LOCUS       XP_047285916             183 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein LOC107984449 [Homo sapiens].
ACCESSION   XP_047285916
VERSION     XP_047285916.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047429960.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000012.12) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..183
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="12"
     Protein         1..183
                     /product="uncharacterized protein LOC107984449"
                     /calculated_mol_wt=19445
     CDS             1..183
                     /gene="LOC107984449"
                     /coded_by="XM_047429960.1:1170..1721"
                     /db_xref="GeneID:107984449"
ORIGIN      
        1 mllwprtcsr dllpgrpyrl pnstpvvcac aqaplthpgp pppfpenvsf avcacarept
       61 rfagttaars papallavva avcacardpr rprslrgrrr crraqdddee dgaaerspap
      121 kdlepqvaas gpggcaqhlq etrgrgrrpa arqsgvvwrq ggeyaggrvd pqhdtvdsar
      181 egv
//
LOCUS       XP_024305057             183 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein LOC107984449 [Homo sapiens].
ACCESSION   XP_024305057
VERSION     XP_024305057.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449289.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000012.12) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..183
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="12"
     Protein         1..183
                     /product="uncharacterized protein LOC107984449"
                     /calculated_mol_wt=19445
     CDS             1..183
                     /gene="LOC107984449"
                     /coded_by="XM_024449289.2:1167..1718"
                     /db_xref="GeneID:107984449"
ORIGIN      
        1 mllwprtcsr dllpgrpyrl pnstpvvcac aqaplthpgp pppfpenvsf avcacarept
       61 rfagttaars papallavva avcacardpr rprslrgrrr crraqdddee dgaaerspap
      121 kdlepqvaas gpggcaqhlq etrgrgrrpa arqsgvvwrq ggeyaggrvd pqhdtvdsar
      181 egv
//
LOCUS       XP_047285917             183 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein LOC107984449 [Homo sapiens].
ACCESSION   XP_047285917
VERSION     XP_047285917.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047429961.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000012.12) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..183
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="12"
     Protein         1..183
                     /product="uncharacterized protein LOC107984449"
                     /calculated_mol_wt=19445
     CDS             1..183
                     /gene="LOC107984449"
                     /coded_by="XM_047429961.1:270..821"
                     /db_xref="GeneID:107984449"
ORIGIN      
        1 mllwprtcsr dllpgrpyrl pnstpvvcac aqaplthpgp pppfpenvsf avcacarept
       61 rfagttaars papallavva avcacardpr rprslrgrrr crraqdddee dgaaerspap
      121 kdlepqvaas gpggcaqhlq etrgrgrrpa arqsgvvwrq ggeyaggrvd pqhdtvdsar
      181 egv
//
LOCUS       XP_024305058             183 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein LOC107984449 [Homo sapiens].
ACCESSION   XP_024305058
VERSION     XP_024305058.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449290.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000012.12) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..183
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="12"
     Protein         1..183
                     /product="uncharacterized protein LOC107984449"
                     /calculated_mol_wt=19445
     CDS             1..183
                     /gene="LOC107984449"
                     /coded_by="XM_024449290.2:267..818"
                     /db_xref="GeneID:107984449"
ORIGIN      
        1 mllwprtcsr dllpgrpyrl pnstpvvcac aqaplthpgp pppfpenvsf avcacarept
       61 rfagttaars papallavva avcacardpr rprslrgrrr crraqdddee dgaaerspap
      121 kdlepqvaas gpggcaqhlq etrgrgrrpa arqsgvvwrq ggeyaggrvd pqhdtvdsar
      181 egv
//
LOCUS       XP_011537392             214 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein LOC100996701 [Homo sapiens].
ACCESSION   XP_011537392
VERSION     XP_011537392.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011539090.2
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000012.12) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 1% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..214
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="12"
     Protein         1..214
                     /product="uncharacterized protein LOC100996701"
                     /calculated_mol_wt=22474
     CDS             1..214
                     /gene="LOC100996701"
                     /coded_by="XM_011539090.2:131..775"
                     /db_xref="GeneID:100996701"
ORIGIN      
        1 maalclrkgp lplcprpshg lkamggegsc qddtesgali flpsddaqpg kalrpqrsgp
       61 ggserrgrgw gragaleeqv rqgpsaqrhp rtqacsrpcs psphcscgkg khgalpqgqc
      121 sawleltmvt vpcchhcshc pggqpgpqlh cawtvwswav pssasracgd ghrrstcqaq
      181 gsctglpplr gclsrlvpgc pcphlrqqdk gkwn
//
LOCUS       XP_047285918             354 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein LOC105370092 isoform X1 [Homo sapiens].
ACCESSION   XP_047285918
VERSION     XP_047285918.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047429962.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000012.12) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..354
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="12"
     Protein         1..354
                     /product="uncharacterized protein LOC105370092 isoform X1"
                     /calculated_mol_wt=37894
     CDS             1..354
                     /gene="LOC105370092"
                     /coded_by="XM_047429962.1:2187..3251"
                     /db_xref="GeneID:105370092"
ORIGIN      
        1 mrteaaewag vawvrtspva apvgarasqp aaralwlsta lvtpgmvpms pqawrrrhlr
       61 vnscltapgc gdgvsaahlw appavpsavp vfpwalgtlg ecpfhlqgll wprrycrpvt
      121 lksettgrrp acwavpqpws dsrcvpaqgc lpatasaqar ttgaaqgslq hltrvmgrps
      181 agagahelpp qpatpageap alvssaclgp weqtrgeglc rghvqmpgla matkdrhprl
      241 arrgrvlsss pilhsfpapt icthahrhll ctpnmqtrqd khehtgtcnl gkhthmptrh
      301 aadpdtithr psshmrlcfq ppvqtgiraq phpplrvheq trtcadpdtr apcg
//
LOCUS       XP_047285919             354 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein LOC105370092 isoform X1 [Homo sapiens].
ACCESSION   XP_047285919
VERSION     XP_047285919.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047429963.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000012.12) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..354
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="12"
     Protein         1..354
                     /product="uncharacterized protein LOC105370092 isoform X1"
                     /calculated_mol_wt=37894
     CDS             1..354
                     /gene="LOC105370092"
                     /coded_by="XM_047429963.1:2038..3102"
                     /db_xref="GeneID:105370092"
ORIGIN      
        1 mrteaaewag vawvrtspva apvgarasqp aaralwlsta lvtpgmvpms pqawrrrhlr
       61 vnscltapgc gdgvsaahlw appavpsavp vfpwalgtlg ecpfhlqgll wprrycrpvt
      121 lksettgrrp acwavpqpws dsrcvpaqgc lpatasaqar ttgaaqgslq hltrvmgrps
      181 agagahelpp qpatpageap alvssaclgp weqtrgeglc rghvqmpgla matkdrhprl
      241 arrgrvlsss pilhsfpapt icthahrhll ctpnmqtrqd khehtgtcnl gkhthmptrh
      301 aadpdtithr psshmrlcfq ppvqtgiraq phpplrvheq trtcadpdtr apcg
//
LOCUS       XP_047285920             354 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein LOC105370092 isoform X1 [Homo sapiens].
ACCESSION   XP_047285920
VERSION     XP_047285920.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047429964.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000012.12) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..354
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="12"
     Protein         1..354
                     /product="uncharacterized protein LOC105370092 isoform X1"
                     /calculated_mol_wt=37894
     CDS             1..354
                     /gene="LOC105370092"
                     /coded_by="XM_047429964.1:1295..2359"
                     /db_xref="GeneID:105370092"
ORIGIN      
        1 mrteaaewag vawvrtspva apvgarasqp aaralwlsta lvtpgmvpms pqawrrrhlr
       61 vnscltapgc gdgvsaahlw appavpsavp vfpwalgtlg ecpfhlqgll wprrycrpvt
      121 lksettgrrp acwavpqpws dsrcvpaqgc lpatasaqar ttgaaqgslq hltrvmgrps
      181 agagahelpp qpatpageap alvssaclgp weqtrgeglc rghvqmpgla matkdrhprl
      241 arrgrvlsss pilhsfpapt icthahrhll ctpnmqtrqd khehtgtcnl gkhthmptrh
      301 aadpdtithr psshmrlcfq ppvqtgiraq phpplrvheq trtcadpdtr apcg
//
LOCUS       XP_047285921             354 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein LOC105370092 isoform X1 [Homo sapiens].
ACCESSION   XP_047285921
VERSION     XP_047285921.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047429965.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000012.12) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..354
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="12"
     Protein         1..354
                     /product="uncharacterized protein LOC105370092 isoform X1"
                     /calculated_mol_wt=37894
     CDS             1..354
                     /gene="LOC105370092"
                     /coded_by="XM_047429965.1:1174..2238"
                     /db_xref="GeneID:105370092"
ORIGIN      
        1 mrteaaewag vawvrtspva apvgarasqp aaralwlsta lvtpgmvpms pqawrrrhlr
       61 vnscltapgc gdgvsaahlw appavpsavp vfpwalgtlg ecpfhlqgll wprrycrpvt
      121 lksettgrrp acwavpqpws dsrcvpaqgc lpatasaqar ttgaaqgslq hltrvmgrps
      181 agagahelpp qpatpageap alvssaclgp weqtrgeglc rghvqmpgla matkdrhprl
      241 arrgrvlsss pilhsfpapt icthahrhll ctpnmqtrqd khehtgtcnl gkhthmptrh
      301 aadpdtithr psshmrlcfq ppvqtgiraq phpplrvheq trtcadpdtr apcg
//
LOCUS       XP_047285922             354 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein LOC105370092 isoform X1 [Homo sapiens].
ACCESSION   XP_047285922
VERSION     XP_047285922.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047429966.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000012.12) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..354
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="12"
     Protein         1..354
                     /product="uncharacterized protein LOC105370092 isoform X1"
                     /calculated_mol_wt=37894
     CDS             1..354
                     /gene="LOC105370092"
                     /coded_by="XM_047429966.1:1261..2325"
                     /db_xref="GeneID:105370092"
ORIGIN      
        1 mrteaaewag vawvrtspva apvgarasqp aaralwlsta lvtpgmvpms pqawrrrhlr
       61 vnscltapgc gdgvsaahlw appavpsavp vfpwalgtlg ecpfhlqgll wprrycrpvt
      121 lksettgrrp acwavpqpws dsrcvpaqgc lpatasaqar ttgaaqgslq hltrvmgrps
      181 agagahelpp qpatpageap alvssaclgp weqtrgeglc rghvqmpgla matkdrhprl
      241 arrgrvlsss pilhsfpapt icthahrhll ctpnmqtrqd khehtgtcnl gkhthmptrh
      301 aadpdtithr psshmrlcfq ppvqtgiraq phpplrvheq trtcadpdtr apcg
//
LOCUS       XP_047285923             388 aa            linear   PRI 05-AUG-2025
DEFINITION  LOW QUALITY PROTEIN: S-antigen protein isoform X1 [Homo sapiens].
ACCESSION   XP_047285923
VERSION     XP_047285923.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047429967.1
KEYWORDS    RefSeq; corrected model.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000012.12) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            frameshifts :: corrected 6 indels
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..388
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="12"
     Protein         1..388
                     /product="LOW QUALITY PROTEIN: S-antigen protein isoform
                     X1"
                     /calculated_mol_wt=41553
     CDS             1..388
                     /gene="MUC8"
                     /coded_by="XM_047429967.1:232..1398"
                     /note="The sequence of the model RefSeq protein was
                     modified relative to its source genomic sequence to
                     represent the inferred CDS: deleted 6 bases in 6 codons"
                     /db_xref="GeneID:100129528"
                     /db_xref="HGNC:HGNC:7519"
                     /db_xref="MIM:601932"
ORIGIN      
        1 mkwtrapqil twvssepvwl rvapfwgclf lqqmmpalte pvhvhhelpt sspgrdpgpr
       61 aahvlsrkgp gstscprplq egtpgsraah alsrrghrvh elptsspggd tgfmscprpf
      121 qegtpgsraa hvlsrrghrg prvhelptss pgrdpgstsc prplqegtrv tncprplqeg
      181 tpgsraahvl srrghrvhel ptpspgrdpg fmscprplqe gtrvtncprp lqegtrvtsc
      241 prrlqegtrv tscprplqeg trvtncpral qegtpgsraa halsrkgprv helptsspgg
      301 dtgftscprp lqegtpgsra ahalsrrghr vhelptsspg rdpghelpts spggdtgfts
      361 cprtfqegtp gsgllpahiv plckseer
//
LOCUS       XP_047285924             253 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein LOC124903061 [Homo sapiens].
ACCESSION   XP_047285924
VERSION     XP_047285924.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047429968.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000012.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..253
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="12"
     Protein         1..253
                     /product="uncharacterized protein LOC124903061"
                     /calculated_mol_wt=27315
     CDS             1..253
                     /gene="LOC124903061"
                     /coded_by="XM_047429968.1:94..855"
                     /db_xref="GeneID:124903061"
ORIGIN      
        1 mgthpvgqte gwmdgwtgwr plpwgthpag wtegrmdgwt gwrpllwgth ptgqtkdgwt
       61 agqaggpchg hsprgtdrrt dgrldrleap smghspratd rrtdgrldgp eapavdthpa
      121 gqtegrmdgw tgwrplpwtl tpqdrqkdgw tagqaggpcr grsprscwas vgsweistav
      181 qcagrafvls sqrprlrlcc iwppagqaps eegllrvcgs rrpssvcdsh ppptpahfwe
      241 hlpggfggps ilp
//
LOCUS       XP_047285932             160 aa            linear   PRI 05-AUG-2025
DEFINITION  polyadenylate-binding protein 4-like [Homo sapiens].
ACCESSION   XP_047285932
VERSION     XP_047285932.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047429976.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000012.12) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 14% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..160
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="12"
     Protein         1..160
                     /product="polyadenylate-binding protein 4-like"
                     /calculated_mol_wt=16988
     Region          <39..140
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     CDS             1..160
                     /gene="LOC100996696"
                     /coded_by="XM_047429976.1:1..483"
                     /db_xref="GeneID:100996696"
ORIGIN      
        1 msaaasleaf pqlcrtqrsa llfaavaaaa pragavaryk yassvrsshl avqrlhapqp
       61 evqvqgqepl ttsmlaaahp qeqkqmlger lfpliqtmhs nlagkitgml leihnsellh
      121 mlefpeslhs kvdeavavlq ahhakkeaaq kvgavaaats
//
LOCUS       XP_047285933             517 aa            linear   PRI 05-AUG-2025
DEFINITION  vegetative cell wall protein gp1-like [Homo sapiens].
ACCESSION   XP_047285933
VERSION     XP_047285933.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047429977.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000012.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 41% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..517
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="12"
     Protein         1..517
                     /product="vegetative cell wall protein gp1-like"
                     /calculated_mol_wt=52978
     Region          <17..476
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..517
                     /gene="LOC124903090"
                     /coded_by="XM_047429977.1:1..1554"
                     /db_xref="GeneID:124903090"
ORIGIN      
        1 mppsmlpfpl afptgepggp ydlppnipwv pspmsqhppr pllcvraspa spassplcpg
       61 iprilcpvsr hpphplpcvp aspacvpcit spvsrhrlpc vprilcpvsp assplcpgip
      121 rvlspvsqhp prplpcvpas passplcpgi prvlspvsrh pprplpcvpa spassplcpg
      181 iprvlspvsr hpprplpcvr aspvspassp lcpgiprvls pvsrhpprpl pcvpaspass
      241 plcpgiprvl spvsrhpprp lpcvpaspas splcpgiprv lspvsrhppr plpcvpaspa
      301 ssplcpgipr vlspvsrhpp rplpcvpasp assplcpgip rvlspvsrhp prplpcvpas
      361 passplcpgi pcvprilspv srhpprplpc vpaspasspl cpgiprvlsp vsrhpprplp
      421 cvpaspassp lcpgiprvls pvsrhpprpl pcvpaspass plcpgiprvl spvsrhpprp
      481 lpcvpaspvs passplcpgi prilspvsla fsvsspl
//
LOCUS       XP_047285937             624 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein C13orf46 isoform X1 [Homo sapiens].
ACCESSION   XP_047285937
VERSION     XP_047285937.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047429981.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..624
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..624
                     /product="uncharacterized protein C13orf46 isoform X1"
                     /calculated_mol_wt=66530
     Region          <137..>436
                     /region_name="PRK15387"
                     /note="type III secretion system effector E3 ubiquitin
                     transferase SspH2"
                     /db_xref="CDD:185285"
     CDS             1..624
                     /gene="C13orf46"
                     /coded_by="XM_047429981.1:363..2237"
                     /db_xref="GeneID:100507747"
                     /db_xref="HGNC:HGNC:53786"
ORIGIN      
        1 mlllstrcss sppdapplhq illlstryys ssppdaprlh qmlllstgcs ssrrdaprll
       61 emllvstgcs ssppdapclr rmlllfakyy sssppdptpp lrqillhlsa rsysssppdp
      121 tplcqillll sarsyssslp dptprlrqml llvsarcsss prdapplcem lllstgcsss
      181 prdappllem llvstgcsss ppaaprlrrl llvsagcsss lpdttprlcq tllllsarhy
      241 ssslpdttpc lcqtlllvsa rhyssslpda pplhemllls trcsssprda prlrqmllrs
      301 trcsssppda ppllemllls tgcsssppda prhrrmllvs agcsssppda pplhqillll
      361 stryysslpd ttplrqilll lsarcssspp daprlhgmll vstgcssspp dappllemll
      421 istgcssspp aaaplhqlll iptgcssspp dapplrqill llsarsysss lpdppprlrq
      481 illlvsarss sssppdappr lrqmllvsar csssprdaph lhrmllistg csssppaapr
      541 lhqledsspf lpwplaqwlv gwgqrplghs rggsalcgpr vscsswkhph qagvrgagqg
      601 wsiccvtkvp agarstvdaa eprl
//
LOCUS       XP_047285938             624 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein C13orf46 isoform X1 [Homo sapiens].
ACCESSION   XP_047285938
VERSION     XP_047285938.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047429982.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..624
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..624
                     /product="uncharacterized protein C13orf46 isoform X1"
                     /calculated_mol_wt=66530
     Region          <137..>436
                     /region_name="PRK15387"
                     /note="type III secretion system effector E3 ubiquitin
                     transferase SspH2"
                     /db_xref="CDD:185285"
     CDS             1..624
                     /gene="C13orf46"
                     /coded_by="XM_047429982.1:363..2237"
                     /db_xref="GeneID:100507747"
                     /db_xref="HGNC:HGNC:53786"
ORIGIN      
        1 mlllstrcss sppdapplhq illlstryys ssppdaprlh qmlllstgcs ssrrdaprll
       61 emllvstgcs ssppdapclr rmlllfakyy sssppdptpp lrqillhlsa rsysssppdp
      121 tplcqillll sarsyssslp dptprlrqml llvsarcsss prdapplcem lllstgcsss
      181 prdappllem llvstgcsss ppaaprlrrl llvsagcsss lpdttprlcq tllllsarhy
      241 ssslpdttpc lcqtlllvsa rhyssslpda pplhemllls trcsssprda prlrqmllrs
      301 trcsssppda ppllemllls tgcsssppda prhrrmllvs agcsssppda pplhqillll
      361 stryysslpd ttplrqilll lsarcssspp daprlhgmll vstgcssspp dappllemll
      421 istgcssspp aaaplhqlll iptgcssspp dapplrqill llsarsysss lpdppprlrq
      481 illlvsarss sssppdappr lrqmllvsar csssprdaph lhrmllistg csssppaapr
      541 lhqledsspf lpwplaqwlv gwgqrplghs rggsalcgpr vscsswkhph qagvrgagqg
      601 wsiccvtkvp agarstvdaa eprl
//
LOCUS       XP_047285939             624 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein C13orf46 isoform X1 [Homo sapiens].
ACCESSION   XP_047285939
VERSION     XP_047285939.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047429983.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..624
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..624
                     /product="uncharacterized protein C13orf46 isoform X1"
                     /calculated_mol_wt=66530
     Region          <137..>436
                     /region_name="PRK15387"
                     /note="type III secretion system effector E3 ubiquitin
                     transferase SspH2"
                     /db_xref="CDD:185285"
     CDS             1..624
                     /gene="C13orf46"
                     /coded_by="XM_047429983.1:363..2237"
                     /db_xref="GeneID:100507747"
                     /db_xref="HGNC:HGNC:53786"
ORIGIN      
        1 mlllstrcss sppdapplhq illlstryys ssppdaprlh qmlllstgcs ssrrdaprll
       61 emllvstgcs ssppdapclr rmlllfakyy sssppdptpp lrqillhlsa rsysssppdp
      121 tplcqillll sarsyssslp dptprlrqml llvsarcsss prdapplcem lllstgcsss
      181 prdappllem llvstgcsss ppaaprlrrl llvsagcsss lpdttprlcq tllllsarhy
      241 ssslpdttpc lcqtlllvsa rhyssslpda pplhemllls trcsssprda prlrqmllrs
      301 trcsssppda ppllemllls tgcsssppda prhrrmllvs agcsssppda pplhqillll
      361 stryysslpd ttplrqilll lsarcssspp daprlhgmll vstgcssspp dappllemll
      421 istgcssspp aaaplhqlll iptgcssspp dapplrqill llsarsysss lpdppprlrq
      481 illlvsarss sssppdappr lrqmllvsar csssprdaph lhrmllistg csssppaapr
      541 lhqledsspf lpwplaqwlv gwgqrplghs rggsalcgpr vscsswkhph qagvrgagqg
      601 wsiccvtkvp agarstvdaa eprl
//
LOCUS       XP_047285940             587 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein C13orf46 isoform X2 [Homo sapiens].
ACCESSION   XP_047285940
VERSION     XP_047285940.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047429984.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..587
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..587
                     /product="uncharacterized protein C13orf46 isoform X2"
                     /calculated_mol_wt=62691
     CDS             1..587
                     /gene="C13orf46"
                     /coded_by="XM_047429984.1:343..2106"
                     /db_xref="GeneID:100507747"
                     /db_xref="HGNC:HGNC:53786"
ORIGIN      
        1 mlllstrcss sppdapplhq mlllstryys sppdttpplh qmllvstrcs ssppdvpplv
       61 emllvssrcs ssppgaprlh rmllvsagcs ssspnttppl rqillllsar yystsppdpt
      121 pplrqillls arsysssppd ptpplcqill lvsarcssss ppdaprlrem lllsarcsss
      181 ppdappllem lllssrcsss ppaaprlrrl llvsagcsss ppdapplcqt lllvsarhys
      241 ssppdttprl cqtlllvsar hysssppdtt prlcqmllrs trcsssprda pplhemllvs
      301 arcssaprda prlrqmllrs srcsssppda phlrrmllvt agcsssppda pplrrmllls
      361 tryysssppd ttplcqilll saryyssspp daprlrqmll vstgcssspr dapplhqmll
      421 lssrcssspp daprlhqlll lstscssspl daphprrmll lsarsysssp pdptpplcqi
      481 lllvsarsss ssppdppprl rqmlllvsar cssslpdapp phemllistg csssppdapr
      541 lhqlllvsts wrtpapscpg lllsgllggd rgpwgtagea qpfvglv
//
LOCUS       XP_047285941             212 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein C13orf46 isoform X3 [Homo sapiens].
ACCESSION   XP_047285941
VERSION     XP_047285941.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047429985.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..212
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..212
                     /product="uncharacterized protein C13orf46 isoform X3"
                     /calculated_mol_wt=23301
     CDS             1..212
                     /gene="C13orf46"
                     /coded_by="XM_047429985.1:80..718"
                     /db_xref="GeneID:100507747"
                     /db_xref="HGNC:HGNC:53786"
ORIGIN      
        1 mekdtgtthr rhrpglralp sgvalghlka aseaselqrs rslgglqpeg dppsrprkph
       61 kelesedqgk dpssnaedas cqknlaqdkk esfstlgklg hesgkqdper eksdleasmq
      121 evqegehadg glqeakeqea esiklndlqe eekasvfvei dlgdhaeevv tdakkeekps
      181 qmdvedlsed emqtswvcci pystrkrake st
//
LOCUS       XP_006720058             192 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein C13orf46 isoform X4 [Homo sapiens].
ACCESSION   XP_006720058
VERSION     XP_006720058.4
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006719995.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XP_006720058.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..192
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..192
                     /product="uncharacterized protein C13orf46 isoform X4"
                     /calculated_mol_wt=20991
     CDS             1..192
                     /gene="C13orf46"
                     /coded_by="XM_006719995.4:80..658"
                     /db_xref="GeneID:100507747"
                     /db_xref="HGNC:HGNC:53786"
ORIGIN      
        1 mekdtgtthr rhrpglralp sgvalghlka aseaselqrs rslgglqpeg dppsrprkph
       61 kelesedqgk dpssnaedas cqknlaqdkk esfstlgklg hesgkqdper eksdleasmq
      121 evqegehadg glqeakeqea esiklndlqe eekasvfvei dlgdhaeevv tdakkeekps
      181 qmdvedlsed ef
//
LOCUS       XP_047285942             175 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein C13orf46 isoform X5 [Homo sapiens].
ACCESSION   XP_047285942
VERSION     XP_047285942.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047429986.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..175
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..175
                     /product="uncharacterized protein C13orf46 isoform X5"
                     /calculated_mol_wt=18785
     CDS             1..175
                     /gene="C13orf46"
                     /coded_by="XM_047429986.1:80..607"
                     /db_xref="GeneID:100507747"
                     /db_xref="HGNC:HGNC:53786"
ORIGIN      
        1 mekdtgtthr rhrpglralp sgvalghlka aseaselqrs rslgglqpeg dppsrprkph
       61 kelesedqgk dpssnaedas cqknlaqdkk esfstlgklg hesgkqdper eksdleasmq
      121 evqegehadg glqeakeqea esiklndlqe eesilpsalp svpgalvqhc qdlgt
//
LOCUS       XP_016875789             485 aa            linear   PRI 05-AUG-2025
DEFINITION  glypican-6 isoform X1 [Homo sapiens].
ACCESSION   XP_016875789
VERSION     XP_016875789.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020300.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..485
                     /product="glypican-6 isoform X1"
                     /calculated_mol_wt=55129
     Region          1..478
                     /region_name="Glypican"
                     /note="pfam01153"
                     /db_xref="CDD:460084"
     CDS             1..485
                     /gene="GPC6"
                     /gene_synonym="OMIMD1"
                     /coded_by="XM_017020300.2:75..1532"
                     /db_xref="GeneID:10082"
                     /db_xref="HGNC:HGNC:4454"
                     /db_xref="MIM:604404"
ORIGIN      
        1 medklsqqsk lefenlveet shfvrttfvs rhkkfdeffr ellenaeksl ndmfvrtygm
       61 lymqnsevfq dlftelkryy tggnvnleem lndfwarlle rmfqlinpqy hfsedylecv
      121 skytdqlkpf gdvprklkiq vtrafiaart fvqgltvgre vanrvskvsp tpgciralmk
      181 mlycpycrgl ptvrpcnnyc lnvmkgclan qadldtewnl fidamllvae rlegpfnies
      241 vmdpidvkis eaimnmqens mqvsakvfqg cgqpkpapal rsarsapenf ntrfrpynpe
      301 erpttaagts ldrlvtdike klklskkvws alpytickde svtagtsnee ecwnghskar
      361 ylpeimndgl tnqinnpevd vditrpdtfi rqqimalrvm tnklknayng ndvnfqdtsd
      421 essgsgsgsg cmddvcptef efvtteapav dpdrrevdss aaqrghslls wsltcivlal
      481 qrlcr
//
LOCUS       XP_047285946             485 aa            linear   PRI 05-AUG-2025
DEFINITION  glypican-6 isoform X1 [Homo sapiens].
ACCESSION   XP_047285946
VERSION     XP_047285946.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047429990.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..485
                     /product="glypican-6 isoform X1"
                     /calculated_mol_wt=55129
     Region          1..478
                     /region_name="Glypican"
                     /note="pfam01153"
                     /db_xref="CDD:460084"
     CDS             1..485
                     /gene="GPC6"
                     /gene_synonym="OMIMD1"
                     /coded_by="XM_047429990.1:10205..11662"
                     /db_xref="GeneID:10082"
                     /db_xref="HGNC:HGNC:4454"
                     /db_xref="MIM:604404"
ORIGIN      
        1 medklsqqsk lefenlveet shfvrttfvs rhkkfdeffr ellenaeksl ndmfvrtygm
       61 lymqnsevfq dlftelkryy tggnvnleem lndfwarlle rmfqlinpqy hfsedylecv
      121 skytdqlkpf gdvprklkiq vtrafiaart fvqgltvgre vanrvskvsp tpgciralmk
      181 mlycpycrgl ptvrpcnnyc lnvmkgclan qadldtewnl fidamllvae rlegpfnies
      241 vmdpidvkis eaimnmqens mqvsakvfqg cgqpkpapal rsarsapenf ntrfrpynpe
      301 erpttaagts ldrlvtdike klklskkvws alpytickde svtagtsnee ecwnghskar
      361 ylpeimndgl tnqinnpevd vditrpdtfi rqqimalrvm tnklknayng ndvnfqdtsd
      421 essgsgsgsg cmddvcptef efvtteapav dpdrrevdss aaqrghslls wsltcivlal
      481 qrlcr
//
LOCUS       XP_016875791             324 aa            linear   PRI 05-AUG-2025
DEFINITION  glypican-6 isoform X2 [Homo sapiens].
ACCESSION   XP_016875791
VERSION     XP_016875791.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020302.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..324
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..324
                     /product="glypican-6 isoform X2"
                     /calculated_mol_wt=35767
     Region          <62..317
                     /region_name="Glypican"
                     /note="pfam01153"
                     /db_xref="CDD:460084"
     CDS             1..324
                     /gene="GPC6"
                     /gene_synonym="OMIMD1"
                     /coded_by="XM_017020302.2:5247..6221"
                     /db_xref="GeneID:10082"
                     /db_xref="HGNC:HGNC:4454"
                     /db_xref="MIM:604404"
ORIGIN      
        1 mfaplngvvr esftdkvtfe qtteggegai gqglwgnsit grrnsrckaw rqdciwlcpd
       61 pdamllvaer legpfniesv mdpidvkise aimnmqensm qvsakvfqgc gqpkpapalr
      121 sarsapenfn trfrpynpee rpttaagtsl drlvtdikek lklskkvwsa lpytickdes
      181 vtagtsneee cwnghskary lpeimndglt nqinnpevdv ditrpdtfir qqimalrvmt
      241 nklknayngn dvnfqdtsde ssgsgsgsgc mddvcptefe fvtteapavd pdrrevdssa
      301 aqrghsllsw sltcivlalq rlcr
//
LOCUS       XP_006719812            3019 aa            linear   PRI 05-AUG-2025
DEFINITION  protein furry homolog isoform X3 [Homo sapiens].
ACCESSION   XP_006719812
VERSION     XP_006719812.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006719749.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..3019
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..3019
                     /product="protein furry homolog isoform X3"
                     /calculated_mol_wt=339380
     Region          162..668
                     /region_name="MOR2-PAG1_N"
                     /note="Cell morphogenesis N-terminal; pfam14222"
                     /db_xref="CDD:464107"
     Region          731..1895
                     /region_name="MOR2-PAG1_mid"
                     /note="Cell morphogenesis central region; pfam14228"
                     /db_xref="CDD:433790"
     Region          2039..2292
                     /region_name="MOR2-PAG1_C"
                     /note="Cell morphogenesis C-terminal; pfam14225"
                     /db_xref="CDD:464109"
     Region          2316..3019
                     /region_name="Fry_C"
                     /note="Furry protein C-terminal; pfam19421"
                     /db_xref="CDD:466072"
     CDS             1..3019
                     /gene="FRY"
                     /gene_synonym="13CDNA73; 214K23.2; bA207N4.2; bA37E23.1;
                     C13orf14; CG003"
                     /coded_by="XM_006719749.4:242..9301"
                     /db_xref="GeneID:10129"
                     /db_xref="HGNC:HGNC:20367"
                     /db_xref="MIM:614818"
ORIGIN      
        1 meittacwrr scvisfikgl aspvgngyik ppvppasgth rekgpptmlp invdpdskpg
       61 eyvlkslfvn fttqaerkir iimaeplekp ltkslqrged pqfdqvissm sslseyclps
      121 ilrtlfdwyk rqngiedesh eyrprtsnks ksdeqqrdyl merrdlaidf ifslvlievl
      181 kqiplhpvid slihdvinla fkhfkykegy lgpntgnmhi vadlyaevig vlaqakfpav
      241 kkkfmaelke lrhkeqnpyv vqsiislimg mkffrikmyp vedfeaslqf mqecahyfle
      301 vkdkdikhal aglfveilvp vaaavknevn vpclrnfves lydttlelss rkkhslalyp
      361 lvtcllcvsq kqlflnrwhi flnnclsnlk nkdpkmarva leslyrllwv ymirikcesn
      421 tatqsrliti ittlfpkgsr gvvprdmpln ifvkiiqfia qerldfamke iifdflcvgk
      481 pakafslnpe rmniglrafl viadslqqkd geppmpvtga vlpsgntlrv kktylsktlt
      541 eeeakmigms lyysqvrkav dnilrhldke vgrcmmltnv qmlnkepedm itgerkpkid
      601 lfrtcvaaip rllpdgmskl elidllarls ihmddelrhi aqnslqgllv dfsdwredvl
      661 fgftnfllre vndmhhtlld sslklllqll tqwklviqtq gkvyeqanki rnseliangs
      721 shriqsergp hcsvlhaveg falvllcsfq vatrklsvli lkeiralfia lgqpedddrp
      781 midvmdqlss silesfihva vsdsatlplt hnvdlqwlve wnavlvnshy dvkspshvwi
      841 faqsvkdpwv lclfsflrqe nlpkhcptal syawpyaftr lqsvmplvdp nspinakkts
      901 tagsgdnyvt lwrnylilcf gvakpsimsp ghlrastpei mattpdgtvs ydnkaigtps
      961 vgvllkqlvp lmrlesieit eslvlgfgrt nslvfrelve elhplmkeal errpenkkrr
     1021 errdllrlql lrifellada gvisdstnga lerdtlalga lfleyvdltr mlleaendke
     1081 veilkdirah fsamvanliq cvpvhhrrfl fpqqslrhhl filfsqwagp fsimftpldr
     1141 ysdrnhqitr yqycalkams avlccgpvfd nvglspdgyl ykwldnilac qdlrvhqlgc
     1201 evvvllleln pdqinlfnwa idrcytgsyq lasgcfkaia tvcgsrnypf divtllnlvl
     1261 fkasdtnrei yeismqlmqi leaklfvysk kvaeqrpgsi lygthgplpp lysvslalls
     1321 celarmypel tlplfsevsq rfptthpngr qimltyllpw lhnielvdsr lllpgsspss
     1381 pedevkdreg dvtashglrg ngwgspeats lvlnnlmymt akygdevpgp emenawnala
     1441 nnekwsnnlr itlqflislc gvssdtvllp yikkvaiylc rnntiqtmee llfelqqtep
     1501 vnpivqhcdn ppfyrftass kasaaasgtt sssntvvagq enfpdaeenk ilkesderfs
     1561 nvirahtrle srysnssggs ydedkndpis pytgwlltit etkqpqplpm pctggcwapl
     1621 vdylpetitp rgplhrcnia vifmtemvvd hsvredwalh lplllhavfl gldhyrpevf
     1681 ehskklllhl lialscnsnf hsiasvllqt remgeaktlt vqpayqpeyl ytggfdflre
     1741 dqsspvpdsg lsssstsssi slggssgnlp qmtqevedvd taaetdekan klieflttra
     1801 fgplwchedi tpknqnsksa eqltnflrhv vsvfkdsksg fhlehqlsev alqtalasss
     1861 rhyagrsfqi fralkqplsa halsdllsrl vevigehgde iqgyvmeall tleaavdnls
     1921 dclknsdllt vlsrssspdl sssskltasr kstgqlnmnp gttsgntata ersrhqrsfs
     1981 vpkkfgvidr ssdpprsatl driqactqqg lssktrssss lkdsltdpsh inhptnllat
     2041 ifwvtvalme sdfefeylma lrllsrllah mpldkaenre kleklqaqlk wadfsglqql
     2101 llkgftsltt tdltlqlfsl ltpvskismv dashaigfpl nvlcllpqli qhfenpnqfc
     2161 kdiaeriaqv cleeknpkls nlahvmtlyk thsytrdcat wvnvvcrylh eayaditlnm
     2221 vtylaellek glpsvqqpll qviysllsym dlsvvpvkqf nvevlktiek yvqsvhwrea
     2281 lnilklvvsr saslvlpsyq hsdlskieih rvwtsaskel pgktldfhfd isetpiigrr
     2341 ydelqnssgr dgkpramavt rstsstssgs nsnvlvpvsw krpqysqkrt keklvhvlsl
     2401 cgqevglskn psvifsscgd ldllehqtsl vssedgareq enmddtnseq qfrvfrdfdf
     2461 ldveledgee lqgesmdnfn wgvrrrslds ldkcdmqile erqlsgstps lnkmhhedsd
     2521 esseeedlta sqilehsdli mtlspseetn pmellttacd stpaephsfn trmssfdasl
     2581 pdmnnlqise gskaeavree edttvheddl sssinelpaa fecsdsfsld mtegeekgnr
     2641 aldqftlasf gegdrgvspp pspffsaila afqpaacdda eeawrshinq lmcdsdgsca
     2701 vytfhvfssl fkniqkrfcf ltcdaasylg dnlrgigskf vsssqmltsc secptlfvda
     2761 etllscglld klkfsvlelq eyldtynnrk eatlswlanc katfaggsrd gvitcqpgds
     2821 eekqmeslaq lelcqrlykl hfqllllfqs yckligqvhe vssmpellnm srelsdlkkh
     2881 lkeasaviaa dplysdgaws eptftsteaa iqsmleclkn nelgkalrqi recrslwpnd
     2941 ifgsssddev qtllniyfrh qtlgqtgtya lvgsnqslte ictklmelnm eirdmirraq
     3001 syrvlttflp dssvsgtsl
//
LOCUS       XP_016875795            2072 aa            linear   PRI 05-AUG-2025
DEFINITION  protein furry homolog isoform X4 [Homo sapiens].
ACCESSION   XP_016875795
VERSION     XP_016875795.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020306.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2072
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..2072
                     /product="protein furry homolog isoform X4"
                     /calculated_mol_wt=231762
     Region          <196..948
                     /region_name="MOR2-PAG1_mid"
                     /note="Cell morphogenesis central region; pfam14228"
                     /db_xref="CDD:433790"
     Region          1092..1345
                     /region_name="MOR2-PAG1_C"
                     /note="Cell morphogenesis C-terminal; pfam14225"
                     /db_xref="CDD:464109"
     Region          1369..2072
                     /region_name="Fry_C"
                     /note="Furry protein C-terminal; pfam19421"
                     /db_xref="CDD:466072"
     CDS             1..2072
                     /gene="FRY"
                     /gene_synonym="13CDNA73; 214K23.2; bA207N4.2; bA37E23.1;
                     C13orf14; CG003"
                     /coded_by="XM_017020306.2:56..6274"
                     /db_xref="GeneID:10129"
                     /db_xref="HGNC:HGNC:20367"
                     /db_xref="MIM:614818"
ORIGIN      
        1 mlqknysaig tpsvgvllkq lvplmrlesi eiteslvlgf grtnslvfre lveelhplmk
       61 ealerrpenk krrerrdllr lqllrifell adagvisdst ngalerdtla lgalfleyvd
      121 ltrmlleaen dkeveilkdi rahfsamvan liqcvpvhhr rflfpqqslr hhlfilfsqw
      181 agpfsimftp ldrysdrnhq itryqycalk amsavlccgp vfdnvglspd gylykwldni
      241 lacqdlrvhq lgcevvvlll elnpdqinlf nwaidrcytg syqlasgcfk aiatvcgsrn
      301 ypfdivtlln lvlfkasdtn reiyeismql mqileaklfv yskkvaeqrp gsilygthgp
      361 lpplysvsla llscelarmy peltlplfse vsqrfptthp ngrqimltyl lpwlhnielv
      421 dsrlllpgss psspedevkd regdvtashg lrgngwgspe atslvlnnlm ymtakygdev
      481 pgpemenawn alannekwsn nlritlqfli slcgvssdtv llpyikkvai ylcrnntiqt
      541 meellfelqq tepvnpivqh cdnppfyrft asskasaaas gttsssntvv agqenfpdae
      601 enkilkesde rfsnviraht rlesrysnss ggsydedknd pispytgwll titetkqpqp
      661 lpmpctggcw aplvdylpet itprgplhrc niavifmtem vvdhsvredw alhlplllha
      721 vflgldhyrp evfehskkll lhllialscn snfhsiasvl lqtremgeak tltvqpayqp
      781 eylytggfdf lredqsspvp dsglssssts ssislggssg nlpqmtqeve dvdtaaetde
      841 kanklieflt trafgplwch editpknqns ksaeqltnfl rhvvsvfkds ksgfhlehql
      901 sevalqtala sssrhyagrs fqifralkqp lsahalsdll srlvevigeh gdeiqgyvme
      961 alltleaavd nlsdclknsd lltvlsrsss pdlssssklt asrkstgqln mnpgttsgnt
     1021 ataersrhqr sfsvpkkfgv idrssdpprs atldriqact qqglssktrs ssslkdsltd
     1081 pshinhptnl latifwvtva lmesdfefey lmalrllsrl lahmpldkae nrekleklqa
     1141 qlkwadfsgl qqlllkgfts ltttdltlql fslltpvski smvdashaig fplnvlcllp
     1201 qliqhfenpn qfckdiaeri aqvcleeknp klsnlahvmt lykthsytrd catwvnvvcr
     1261 ylheayadit lnmvtylael lekglpsvqq pllqviysll symdlsvvpv kqfnvevlkt
     1321 iekyvqsvhw realnilklv vsrsaslvlp syqhsdlski eihrvwtsas kelpgktldf
     1381 hfdisetpii grrydelqns sgrdgkpram avtrstssts sgsnsnvlvp vswkrpqysq
     1441 krtkeklvhv lslcgqevgl sknpsvifss cgdldllehq tslvssedga reqenmddtn
     1501 seqqfrvfrd fdfldveled geelqgesmd nfnwgvrrrs ldsldkcdmq ileerqlsgs
     1561 tpslnkmhhe dsdesseeed ltasqilehs dlimtlspse etnpmelltt acdstpaeph
     1621 sfntrmssfd aslpdmnnlq isegskaeav reeedttvhe ddlsssinel paafecsdsf
     1681 sldmtegeek gnraldqftl asfgegdrgv spppspffsa ilaafqpaac ddaeeawrsh
     1741 inqlmcdsdg scavytfhvf sslfkniqkr fcfltcdaas ylgdnlrgig skfvsssqml
     1801 tscsecptlf vdaetllscg lldklkfsvl elqeyldtyn nrkeatlswl anckatfagg
     1861 srdgvitcqp gdseekqmes laqlelcqrl yklhfqllll fqsyckligq vhevssmpel
     1921 lnmsrelsdl kkhlkeasav iaadplysdg awseptftst eaaiqsmlec lknnelgkal
     1981 rqirecrslw pndifgsssd devqtllniy frhqtlgqtg tyalvgsnqs lteictklme
     2041 lnmeirdmir raqsyrvltt flpdssvsgt sl
//
LOCUS       XP_047285958             391 aa            linear   PRI 05-AUG-2025
DEFINITION  muscleblind-like protein 2 isoform X1 [Homo sapiens].
ACCESSION   XP_047285958
VERSION     XP_047285958.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430002.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..391
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..391
                     /product="muscleblind-like protein 2 isoform X1"
                     /calculated_mol_wt=42329
     Region          17..40
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Region          178..202
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     CDS             1..391
                     /gene="MBNL2"
                     /gene_synonym="MBLL; MBLL39; PRO2032"
                     /coded_by="XM_047430002.1:1774..2949"
                     /db_xref="GeneID:10150"
                     /db_xref="HGNC:HGNC:16746"
                     /db_xref="MIM:607327"
ORIGIN      
        1 malnvapvrd tkwltlevcr qfqrgtcsrs deeckfahpp kscqvengrv iacfdslkgr
       61 csrenckylh ppthlktqle ingrnnliqq ktaaamlaqq mqfmfpgtpl hpvptfpvgp
      121 aigtntaisf apylapvtpg vglvpteilp ttpvivpgsp pvtvpgstat qkllrtdkle
      181 vcrefqrgnc argetdcrfa hpadstmidt sdntvtvcmd yikgrcmrek ckyfhppahl
      241 qakikaaqhq anqaavaaqa aaaaatvmtq stakamkrpl eatvdlafpp galhplpkrq
      301 aleksngtsa vfnpsvlhyq qaltsaqlqq haafiptgsv lcmtpatsid nseiisrngm
      361 ecqesalrit khcyctyypv sssielpqta c
//
LOCUS       XP_047285959             391 aa            linear   PRI 05-AUG-2025
DEFINITION  muscleblind-like protein 2 isoform X1 [Homo sapiens].
ACCESSION   XP_047285959
VERSION     XP_047285959.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430003.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..391
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..391
                     /product="muscleblind-like protein 2 isoform X1"
                     /calculated_mol_wt=42329
     Region          17..40
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Region          178..202
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     CDS             1..391
                     /gene="MBNL2"
                     /gene_synonym="MBLL; MBLL39; PRO2032"
                     /coded_by="XM_047430003.1:679..1854"
                     /db_xref="GeneID:10150"
                     /db_xref="HGNC:HGNC:16746"
                     /db_xref="MIM:607327"
ORIGIN      
        1 malnvapvrd tkwltlevcr qfqrgtcsrs deeckfahpp kscqvengrv iacfdslkgr
       61 csrenckylh ppthlktqle ingrnnliqq ktaaamlaqq mqfmfpgtpl hpvptfpvgp
      121 aigtntaisf apylapvtpg vglvpteilp ttpvivpgsp pvtvpgstat qkllrtdkle
      181 vcrefqrgnc argetdcrfa hpadstmidt sdntvtvcmd yikgrcmrek ckyfhppahl
      241 qakikaaqhq anqaavaaqa aaaaatvmtq stakamkrpl eatvdlafpp galhplpkrq
      301 aleksngtsa vfnpsvlhyq qaltsaqlqq haafiptgsv lcmtpatsid nseiisrngm
      361 ecqesalrit khcyctyypv sssielpqta c
//
LOCUS       XP_047285960             385 aa            linear   PRI 05-AUG-2025
DEFINITION  muscleblind-like protein 2 isoform X2 [Homo sapiens].
ACCESSION   XP_047285960
VERSION     XP_047285960.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430004.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..385
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..385
                     /product="muscleblind-like protein 2 isoform X2"
                     /calculated_mol_wt=41146
     Region          17..40
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Region          178..202
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     CDS             1..385
                     /gene="MBNL2"
                     /gene_synonym="MBLL; MBLL39; PRO2032"
                     /coded_by="XM_047430004.1:1774..2931"
                     /db_xref="GeneID:10150"
                     /db_xref="HGNC:HGNC:16746"
                     /db_xref="MIM:607327"
ORIGIN      
        1 malnvapvrd tkwltlevcr qfqrgtcsrs deeckfahpp kscqvengrv iacfdslkgr
       61 csrenckylh ppthlktqle ingrnnliqq ktaaamlaqq mqfmfpgtpl hpvptfpvgp
      121 aigtntaisf apylapvtpg vglvpteilp ttpvivpgsp pvtvpgstat qkllrtdkle
      181 vcrefqrgnc argetdcrfa hpadstmidt sdntvtvcmd yikgrcmrek ckyfhppahl
      241 qakikaaqhq anqaavaaqa aaaaatvmtq stakamkrpl eatvdlafpp galhplpkrq
      301 aleksngtsa vfnpsvlhyq qaltsaqlqq haafiptgsv lcmtpatsiv pmmhsatsat
      361 vsaattpats vpfaatatan qiilk
//
LOCUS       XP_047285961             379 aa            linear   PRI 05-AUG-2025
DEFINITION  muscleblind-like protein 2 isoform X3 [Homo sapiens].
ACCESSION   XP_047285961
VERSION     XP_047285961.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430005.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..379
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..379
                     /product="muscleblind-like protein 2 isoform X3"
                     /calculated_mol_wt=41168
     Region          17..40
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Region          178..202
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     CDS             1..379
                     /gene="MBNL2"
                     /gene_synonym="MBLL; MBLL39; PRO2032"
                     /coded_by="XM_047430005.1:1774..2913"
                     /db_xref="GeneID:10150"
                     /db_xref="HGNC:HGNC:16746"
                     /db_xref="MIM:607327"
ORIGIN      
        1 malnvapvrd tkwltlevcr qfqrgtcsrs deeckfahpp kscqvengrv iacfdslkgr
       61 csrenckylh ppthlktqle ingrnnliqq ktaaamlaqq mqfmfpgtpl hpvptfpvgp
      121 aigtntaisf apylapvtpg vglvpteilp ttpvivpgsp pvtvpgstat qkllrtdkle
      181 vcrefqrgnc argetdcrfa hpadstmidt sdntvtvcmd yikgrcmrek ckyfhppahl
      241 qakikaaqhq anqaavaaqa aaaaatvmtq stakamkrpl eatvdlafpp galhplpkrq
      301 aleksngtsa vfnpsvlhyq qaltsaqlqq haafiptdns eiisrngmec qesalritkh
      361 cyctyypvss sielpqtac
//
LOCUS       XP_047285962             373 aa            linear   PRI 05-AUG-2025
DEFINITION  muscleblind-like protein 2 isoform X4 [Homo sapiens].
ACCESSION   XP_047285962
VERSION     XP_047285962.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430006.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..373
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..373
                     /product="muscleblind-like protein 2 isoform X4"
                     /calculated_mol_wt=39984
     Region          17..40
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Region          178..202
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     CDS             1..373
                     /gene="MBNL2"
                     /gene_synonym="MBLL; MBLL39; PRO2032"
                     /coded_by="XM_047430006.1:1774..2895"
                     /db_xref="GeneID:10150"
                     /db_xref="HGNC:HGNC:16746"
                     /db_xref="MIM:607327"
ORIGIN      
        1 malnvapvrd tkwltlevcr qfqrgtcsrs deeckfahpp kscqvengrv iacfdslkgr
       61 csrenckylh ppthlktqle ingrnnliqq ktaaamlaqq mqfmfpgtpl hpvptfpvgp
      121 aigtntaisf apylapvtpg vglvpteilp ttpvivpgsp pvtvpgstat qkllrtdkle
      181 vcrefqrgnc argetdcrfa hpadstmidt sdntvtvcmd yikgrcmrek ckyfhppahl
      241 qakikaaqhq anqaavaaqa aaaaatvmtq stakamkrpl eatvdlafpp galhplpkrq
      301 aleksngtsa vfnpsvlhyq qaltsaqlqq haafiptvpm mhsatsatvs aattpatsvp
      361 faatatanqi ilk
//
LOCUS       XP_047285963             373 aa            linear   PRI 05-AUG-2025
DEFINITION  muscleblind-like protein 2 isoform X5 [Homo sapiens].
ACCESSION   XP_047285963
VERSION     XP_047285963.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430007.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..373
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..373
                     /product="muscleblind-like protein 2 isoform X5"
                     /calculated_mol_wt=40387
     Region          17..40
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Region          178..202
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     CDS             1..373
                     /gene="MBNL2"
                     /gene_synonym="MBLL; MBLL39; PRO2032"
                     /coded_by="XM_047430007.1:1774..2895"
                     /db_xref="GeneID:10150"
                     /db_xref="HGNC:HGNC:16746"
                     /db_xref="MIM:607327"
ORIGIN      
        1 malnvapvrd tkwltlevcr qfqrgtcsrs deeckfahpp kscqvengrv iacfdslkgr
       61 csrenckylh ppthlktqle ingrnnliqq ktaaamlaqq mqfmfpgtpl hpvptfpvgp
      121 aigtntaisf apylapvtpg vglvpteilp ttpvivpgsp pvtvpgstat qkllrtdkle
      181 vcrefqrgnc argetdcrfa hpadstmidt sdntvtvcmd yikgrcmrek ckyfhppahl
      241 qakikaaqhq anqaavaaqa aaaaatvmaf ppgalhplpk rqaleksngt savfnpsvlh
      301 yqqaltsaql qqhaafiptg svlcmtpats idnseiisrn gmecqesalr itkhcyctyy
      361 pvsssielpq tac
//
LOCUS       XP_047285964             373 aa            linear   PRI 05-AUG-2025
DEFINITION  muscleblind-like protein 2 isoform X4 [Homo sapiens].
ACCESSION   XP_047285964
VERSION     XP_047285964.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430008.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..373
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..373
                     /product="muscleblind-like protein 2 isoform X4"
                     /calculated_mol_wt=39984
     Region          17..40
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Region          178..202
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     CDS             1..373
                     /gene="MBNL2"
                     /gene_synonym="MBLL; MBLL39; PRO2032"
                     /coded_by="XM_047430008.1:679..1800"
                     /db_xref="GeneID:10150"
                     /db_xref="HGNC:HGNC:16746"
                     /db_xref="MIM:607327"
ORIGIN      
        1 malnvapvrd tkwltlevcr qfqrgtcsrs deeckfahpp kscqvengrv iacfdslkgr
       61 csrenckylh ppthlktqle ingrnnliqq ktaaamlaqq mqfmfpgtpl hpvptfpvgp
      121 aigtntaisf apylapvtpg vglvpteilp ttpvivpgsp pvtvpgstat qkllrtdkle
      181 vcrefqrgnc argetdcrfa hpadstmidt sdntvtvcmd yikgrcmrek ckyfhppahl
      241 qakikaaqhq anqaavaaqa aaaaatvmtq stakamkrpl eatvdlafpp galhplpkrq
      301 aleksngtsa vfnpsvlhyq qaltsaqlqq haafiptvpm mhsatsatvs aattpatsvp
      361 faatatanqi ilk
//
LOCUS       XP_047285965             367 aa            linear   PRI 05-AUG-2025
DEFINITION  muscleblind-like protein 2 isoform X6 [Homo sapiens].
ACCESSION   XP_047285965
VERSION     XP_047285965.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430009.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..367
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..367
                     /product="muscleblind-like protein 2 isoform X6"
                     /calculated_mol_wt=39203
     Region          17..40
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Region          178..202
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     CDS             1..367
                     /gene="MBNL2"
                     /gene_synonym="MBLL; MBLL39; PRO2032"
                     /coded_by="XM_047430009.1:1774..2877"
                     /db_xref="GeneID:10150"
                     /db_xref="HGNC:HGNC:16746"
                     /db_xref="MIM:607327"
ORIGIN      
        1 malnvapvrd tkwltlevcr qfqrgtcsrs deeckfahpp kscqvengrv iacfdslkgr
       61 csrenckylh ppthlktqle ingrnnliqq ktaaamlaqq mqfmfpgtpl hpvptfpvgp
      121 aigtntaisf apylapvtpg vglvpteilp ttpvivpgsp pvtvpgstat qkllrtdkle
      181 vcrefqrgnc argetdcrfa hpadstmidt sdntvtvcmd yikgrcmrek ckyfhppahl
      241 qakikaaqhq anqaavaaqa aaaaatvmaf ppgalhplpk rqaleksngt savfnpsvlh
      301 yqqaltsaql qqhaafiptg svlcmtpats ivpmmhsats atvsaattpa tsvpfaatat
      361 anqiilk
//
LOCUS       XP_047285966             361 aa            linear   PRI 05-AUG-2025
DEFINITION  muscleblind-like protein 2 isoform X7 [Homo sapiens].
ACCESSION   XP_047285966
VERSION     XP_047285966.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430010.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..361
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..361
                     /product="muscleblind-like protein 2 isoform X7"
                     /calculated_mol_wt=39225
     Region          17..40
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Region          178..202
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     CDS             1..361
                     /gene="MBNL2"
                     /gene_synonym="MBLL; MBLL39; PRO2032"
                     /coded_by="XM_047430010.1:1774..2859"
                     /db_xref="GeneID:10150"
                     /db_xref="HGNC:HGNC:16746"
                     /db_xref="MIM:607327"
ORIGIN      
        1 malnvapvrd tkwltlevcr qfqrgtcsrs deeckfahpp kscqvengrv iacfdslkgr
       61 csrenckylh ppthlktqle ingrnnliqq ktaaamlaqq mqfmfpgtpl hpvptfpvgp
      121 aigtntaisf apylapvtpg vglvpteilp ttpvivpgsp pvtvpgstat qkllrtdkle
      181 vcrefqrgnc argetdcrfa hpadstmidt sdntvtvcmd yikgrcmrek ckyfhppahl
      241 qakikaaqhq anqaavaaqa aaaaatvmaf ppgalhplpk rqaleksngt savfnpsvlh
      301 yqqaltsaql qqhaafiptd nseiisrngm ecqesalrit khcyctyypv sssielpqta
      361 c
//
LOCUS       XP_047285967             355 aa            linear   PRI 05-AUG-2025
DEFINITION  muscleblind-like protein 2 isoform X8 [Homo sapiens].
ACCESSION   XP_047285967
VERSION     XP_047285967.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430011.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..355
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..355
                     /product="muscleblind-like protein 2 isoform X8"
                     /calculated_mol_wt=38042
     Region          17..40
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Region          178..202
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     CDS             1..355
                     /gene="MBNL2"
                     /gene_synonym="MBLL; MBLL39; PRO2032"
                     /coded_by="XM_047430011.1:1774..2841"
                     /db_xref="GeneID:10150"
                     /db_xref="HGNC:HGNC:16746"
                     /db_xref="MIM:607327"
ORIGIN      
        1 malnvapvrd tkwltlevcr qfqrgtcsrs deeckfahpp kscqvengrv iacfdslkgr
       61 csrenckylh ppthlktqle ingrnnliqq ktaaamlaqq mqfmfpgtpl hpvptfpvgp
      121 aigtntaisf apylapvtpg vglvpteilp ttpvivpgsp pvtvpgstat qkllrtdkle
      181 vcrefqrgnc argetdcrfa hpadstmidt sdntvtvcmd yikgrcmrek ckyfhppahl
      241 qakikaaqhq anqaavaaqa aaaaatvmaf ppgalhplpk rqaleksngt savfnpsvlh
      301 yqqaltsaql qqhaafiptv pmmhsatsat vsaattpats vpfaatatan qiilk
//
LOCUS       XP_047285975             344 aa            linear   PRI 05-AUG-2025
DEFINITION  lysophosphatidic acid receptor 6 isoform X1 [Homo sapiens].
ACCESSION   XP_047285975
VERSION     XP_047285975.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430019.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..344
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..344
                     /product="lysophosphatidic acid receptor 6 isoform X1"
                     /calculated_mol_wt=39261
     Region          18..302
                     /region_name="7tmA_LPAR6_P2Y5"
                     /note="lysophosphatidic acid receptor 6, member of the
                     class A family of seven-transmembrane G protein-coupled
                     receptors; cd15156"
                     /db_xref="CDD:320284"
     Region          18..45
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:320284"
     Region          52..77
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320284"
     Site            order(73,76..77,89..94,96..97,100,145,147..151,181,
                     184..186,188..190,192..193,242,245..246,248..249,252,
                     269..270,272..274,277,280..281)
                     /site_type="other"
                     /note="putative ligand binding pocket [chemical binding]"
                     /db_xref="CDD:320284"
     Region          89..119
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320284"
     Region          131..153
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320284"
     Region          181..210
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320284"
     Region          222..252
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320284"
     Region          270..295
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320284"
     CDS             1..344
                     /gene="LPAR6"
                     /gene_synonym="ARWH1; HYPT8; LAH3; LPA-6; P2RY5; P2Y5"
                     /coded_by="XM_047430019.1:1260..2294"
                     /db_xref="GeneID:10161"
                     /db_xref="HGNC:HGNC:15520"
                     /db_xref="MIM:609239"
ORIGIN      
        1 mvsvnsshcf yndsfkytly gcmfsmvfvl glisncvaiy ificvlkvrn etttyminla
       61 msdllfvftl pfrifyfttr nwpfgdllck isvmlfytnm ygsilfltci svdrflaivy
      121 pfksktlrtk rnakivctgv wltviggsap avfvqsthsq gnnaseacfe nfpeatwkty
      181 lsrivifiei vgffipliln vtcssmvlkt ltkpvtlsrs kinktkvlkm ifvhliifcf
      241 cfvpyninli lyslvrtqtf vncsvvaavr tmypitlcia vsnccfdpiv yyftsdtiqn
      301 sikmknwsvr rsdfrfsevh gaenfiqhnl qtlkskifdn esaa
//
LOCUS       XP_047285976             344 aa            linear   PRI 05-AUG-2025
DEFINITION  lysophosphatidic acid receptor 6 isoform X1 [Homo sapiens].
ACCESSION   XP_047285976
VERSION     XP_047285976.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430020.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..344
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..344
                     /product="lysophosphatidic acid receptor 6 isoform X1"
                     /calculated_mol_wt=39261
     Region          18..302
                     /region_name="7tmA_LPAR6_P2Y5"
                     /note="lysophosphatidic acid receptor 6, member of the
                     class A family of seven-transmembrane G protein-coupled
                     receptors; cd15156"
                     /db_xref="CDD:320284"
     Region          18..45
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:320284"
     Region          52..77
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320284"
     Site            order(73,76..77,89..94,96..97,100,145,147..151,181,
                     184..186,188..190,192..193,242,245..246,248..249,252,
                     269..270,272..274,277,280..281)
                     /site_type="other"
                     /note="putative ligand binding pocket [chemical binding]"
                     /db_xref="CDD:320284"
     Region          89..119
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320284"
     Region          131..153
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320284"
     Region          181..210
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320284"
     Region          222..252
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320284"
     Region          270..295
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320284"
     CDS             1..344
                     /gene="LPAR6"
                     /gene_synonym="ARWH1; HYPT8; LAH3; LPA-6; P2RY5; P2Y5"
                     /coded_by="XM_047430020.1:1284..2318"
                     /db_xref="GeneID:10161"
                     /db_xref="HGNC:HGNC:15520"
                     /db_xref="MIM:609239"
ORIGIN      
        1 mvsvnsshcf yndsfkytly gcmfsmvfvl glisncvaiy ificvlkvrn etttyminla
       61 msdllfvftl pfrifyfttr nwpfgdllck isvmlfytnm ygsilfltci svdrflaivy
      121 pfksktlrtk rnakivctgv wltviggsap avfvqsthsq gnnaseacfe nfpeatwkty
      181 lsrivifiei vgffipliln vtcssmvlkt ltkpvtlsrs kinktkvlkm ifvhliifcf
      241 cfvpyninli lyslvrtqtf vncsvvaavr tmypitlcia vsnccfdpiv yyftsdtiqn
      301 sikmknwsvr rsdfrfsevh gaenfiqhnl qtlkskifdn esaa
//
LOCUS       XP_047285977             344 aa            linear   PRI 05-AUG-2025
DEFINITION  lysophosphatidic acid receptor 6 isoform X1 [Homo sapiens].
ACCESSION   XP_047285977
VERSION     XP_047285977.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430021.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..344
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..344
                     /product="lysophosphatidic acid receptor 6 isoform X1"
                     /calculated_mol_wt=39261
     Region          18..302
                     /region_name="7tmA_LPAR6_P2Y5"
                     /note="lysophosphatidic acid receptor 6, member of the
                     class A family of seven-transmembrane G protein-coupled
                     receptors; cd15156"
                     /db_xref="CDD:320284"
     Region          18..45
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:320284"
     Region          52..77
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320284"
     Site            order(73,76..77,89..94,96..97,100,145,147..151,181,
                     184..186,188..190,192..193,242,245..246,248..249,252,
                     269..270,272..274,277,280..281)
                     /site_type="other"
                     /note="putative ligand binding pocket [chemical binding]"
                     /db_xref="CDD:320284"
     Region          89..119
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320284"
     Region          131..153
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320284"
     Region          181..210
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320284"
     Region          222..252
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320284"
     Region          270..295
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320284"
     CDS             1..344
                     /gene="LPAR6"
                     /gene_synonym="ARWH1; HYPT8; LAH3; LPA-6; P2RY5; P2Y5"
                     /coded_by="XM_047430021.1:1044..2078"
                     /db_xref="GeneID:10161"
                     /db_xref="HGNC:HGNC:15520"
                     /db_xref="MIM:609239"
ORIGIN      
        1 mvsvnsshcf yndsfkytly gcmfsmvfvl glisncvaiy ificvlkvrn etttyminla
       61 msdllfvftl pfrifyfttr nwpfgdllck isvmlfytnm ygsilfltci svdrflaivy
      121 pfksktlrtk rnakivctgv wltviggsap avfvqsthsq gnnaseacfe nfpeatwkty
      181 lsrivifiei vgffipliln vtcssmvlkt ltkpvtlsrs kinktkvlkm ifvhliifcf
      241 cfvpyninli lyslvrtqtf vncsvvaavr tmypitlcia vsnccfdpiv yyftsdtiqn
      301 sikmknwsvr rsdfrfsevh gaenfiqhnl qtlkskifdn esaa
//
LOCUS       XP_047285978             344 aa            linear   PRI 05-AUG-2025
DEFINITION  lysophosphatidic acid receptor 6 isoform X1 [Homo sapiens].
ACCESSION   XP_047285978
VERSION     XP_047285978.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430022.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..344
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..344
                     /product="lysophosphatidic acid receptor 6 isoform X1"
                     /calculated_mol_wt=39261
     Region          18..302
                     /region_name="7tmA_LPAR6_P2Y5"
                     /note="lysophosphatidic acid receptor 6, member of the
                     class A family of seven-transmembrane G protein-coupled
                     receptors; cd15156"
                     /db_xref="CDD:320284"
     Region          18..45
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:320284"
     Region          52..77
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320284"
     Site            order(73,76..77,89..94,96..97,100,145,147..151,181,
                     184..186,188..190,192..193,242,245..246,248..249,252,
                     269..270,272..274,277,280..281)
                     /site_type="other"
                     /note="putative ligand binding pocket [chemical binding]"
                     /db_xref="CDD:320284"
     Region          89..119
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320284"
     Region          131..153
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320284"
     Region          181..210
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320284"
     Region          222..252
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320284"
     Region          270..295
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320284"
     CDS             1..344
                     /gene="LPAR6"
                     /gene_synonym="ARWH1; HYPT8; LAH3; LPA-6; P2RY5; P2Y5"
                     /coded_by="XM_047430022.1:1068..2102"
                     /db_xref="GeneID:10161"
                     /db_xref="HGNC:HGNC:15520"
                     /db_xref="MIM:609239"
ORIGIN      
        1 mvsvnsshcf yndsfkytly gcmfsmvfvl glisncvaiy ificvlkvrn etttyminla
       61 msdllfvftl pfrifyfttr nwpfgdllck isvmlfytnm ygsilfltci svdrflaivy
      121 pfksktlrtk rnakivctgv wltviggsap avfvqsthsq gnnaseacfe nfpeatwkty
      181 lsrivifiei vgffipliln vtcssmvlkt ltkpvtlsrs kinktkvlkm ifvhliifcf
      241 cfvpyninli lyslvrtqtf vncsvvaavr tmypitlcia vsnccfdpiv yyftsdtiqn
      301 sikmknwsvr rsdfrfsevh gaenfiqhnl qtlkskifdn esaa
//
LOCUS       XP_047285979             151 aa            linear   PRI 05-AUG-2025
DEFINITION  lysophosphatidic acid receptor 6 isoform X2 [Homo sapiens].
ACCESSION   XP_047285979
VERSION     XP_047285979.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430023.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..151
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..151
                     /product="lysophosphatidic acid receptor 6 isoform X2"
                     /calculated_mol_wt=16277
     CDS             1..151
                     /gene="LPAR6"
                     /gene_synonym="ARWH1; HYPT8; LAH3; LPA-6; P2RY5; P2Y5"
                     /coded_by="XM_047430023.1:180..635"
                     /db_xref="GeneID:10161"
                     /db_xref="HGNC:HGNC:15520"
                     /db_xref="MIM:609239"
ORIGIN      
        1 mhrsswhips wlplarggss lapctsrslc ygsssvettg nkiqvydsfi skhvriiyke
       61 privagfell asrdppasap lsvgitgmsh cpwpkkvlqs egkqkesgst qgmkstgkvk
      121 tpklnilttl gredgrkrae caprsgkmpd l
//
LOCUS       XP_047285980             127 aa            linear   PRI 05-AUG-2025
DEFINITION  lysophosphatidic acid receptor 6 isoform X3 [Homo sapiens].
ACCESSION   XP_047285980
VERSION     XP_047285980.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430024.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..127
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..127
                     /product="lysophosphatidic acid receptor 6 isoform X3"
                     /calculated_mol_wt=13665
     CDS             1..127
                     /gene="LPAR6"
                     /gene_synonym="ARWH1; HYPT8; LAH3; LPA-6; P2RY5; P2Y5"
                     /coded_by="XM_047430024.1:209..592"
                     /db_xref="GeneID:10161"
                     /db_xref="HGNC:HGNC:15520"
                     /db_xref="MIM:609239"
ORIGIN      
        1 mteslcygss svettgnkiq vydsfiskhv riiykepriv agfellasrd ppasaplsvg
       61 itgmshcpwp kkvlqsegkq kesgstqgmk stgkvktpkl nilttlgred grkraecapr
      121 sgkmpdl
//
LOCUS       XP_011533163             200 aa            linear   PRI 05-AUG-2025
DEFINITION  LHFPL tetraspan subfamily member 6 protein isoform X1 [Homo
            sapiens].
ACCESSION   XP_011533163
VERSION     XP_011533163.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534861.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..200
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..200
                     /product="LHFPL tetraspan subfamily member 6 protein
                     isoform X1"
                     /calculated_mol_wt=21467
     Region          8..193
                     /region_name="L_HMGIC_fpl"
                     /note="Lipoma HMGIC fusion partner-like protein;
                     pfam10242"
                     /db_xref="CDD:463019"
     CDS             1..200
                     /gene="LHFPL6"
                     /gene_synonym="LHFP"
                     /coded_by="XM_011534861.2:335..937"
                     /db_xref="GeneID:10186"
                     /db_xref="HGNC:HGNC:6586"
                     /db_xref="MIM:606710"
ORIGIN      
        1 massltctgv iwallsflca atscvgffmp ywlwgsqlgk pvsfgtfrrc sypvhdesrq
       61 mmvmveecgr yasfqgipsa ewrictivtg lgcgllllva ltalmgccvs dlisrtvgrv
      121 aggiqflggl ligagcalyp lgwdseevrq tcgytsgqfd lgkceigway yctgagataa
      181 mllctwlacf sgkkqkhypy
//
LOCUS       XP_047285981             165 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein CFAP97D2 isoform X2 [Homo sapiens].
ACCESSION   XP_047285981
VERSION     XP_047285981.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430025.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..165
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..165
                     /product="uncharacterized protein CFAP97D2 isoform X2"
                     /calculated_mol_wt=19076
     Region          28..110
                     /region_name="Hmw_CFAP97"
                     /note="Hemingway/CFA97; pfam13879"
                     /db_xref="CDD:464014"
     CDS             1..165
                     /gene="CFAP97D2"
                     /coded_by="XM_047430025.1:75..572"
                     /db_xref="GeneID:101929355"
                     /db_xref="HGNC:HGNC:53789"
ORIGIN      
        1 mhgaprltfp caseylwhar ekayqdhrrk vqsaqplvdt rapltfrhlh lklkrlklee
       61 erlsvierdn rlllekvasv mrtrgqtdsk nnskhrslhr gkreqelrrv rkktrpfwke
      121 shtqnhgmel kggvktgagl rspgcwcgis letadtpskk evkld
//
LOCUS       XP_047285982             101 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein CFAP97D2 isoform X3 [Homo sapiens].
ACCESSION   XP_047285982
VERSION     XP_047285982.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430026.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..101
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..101
                     /product="uncharacterized protein CFAP97D2 isoform X3"
                     /calculated_mol_wt=11886
     Region          28..>94
                     /region_name="Hmw_CFAP97"
                     /note="Hemingway/CFA97; pfam13879"
                     /db_xref="CDD:464014"
     CDS             1..101
                     /gene="CFAP97D2"
                     /coded_by="XM_047430026.1:75..380"
                     /db_xref="GeneID:101929355"
                     /db_xref="HGNC:HGNC:53789"
ORIGIN      
        1 mhgaprltfp caseylwhar ekayqdhrrk vqsaqplvdt rapltfrhlh lklkrlklee
       61 erlsvierdn rlllekvasv mrtrgqtdsk nnskhrrfmd a
//
LOCUS       XP_047285983            1092 aa            linear   PRI 05-AUG-2025
DEFINITION  SUMO-specific isopeptidase USPL1 isoform X1 [Homo sapiens].
ACCESSION   XP_047285983
VERSION     XP_047285983.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430027.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1092
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1092
                     /product="SUMO-specific isopeptidase USPL1 isoform X1"
                     /calculated_mol_wt=120309
     Region          226..498
                     /region_name="Peptidase_C98"
                     /note="Ubiquitin-specific peptidase-like, SUMO
                     isopeptidase; pfam15499"
                     /db_xref="CDD:464750"
     Region          572..1090
                     /region_name="DUF4650"
                     /note="Domain of unknown function (DUF4650); pfam15509"
                     /db_xref="CDD:464755"
     CDS             1..1092
                     /gene="USPL1"
                     /gene_synonym="bA121O19.1; C13orf22; D13S106E"
                     /coded_by="XM_047430027.1:1890..5168"
                     /db_xref="GeneID:10208"
                     /db_xref="HGNC:HGNC:20294"
                     /db_xref="MIM:617470"
ORIGIN      
        1 mmdspkigng lpvigpgtdi gisslhmvgy lgknfdsakv psdeycpacr ekgklkalkt
       61 yrisfqesif lcedlqciyp lgskslnnli spdleechtp hkpqkrksle ssykdsllla
      121 nskktrnyia idggkvlnsk hngevydets snlpdssgqq npirtadsle rneileadtv
      181 dmattkdpat vdvsgtgrps pqnegctskl empleskcts fpqalcvqwk nayalcwldc
      241 ilsalvhsee lkntvtglcs keesifwrll tkynqantll ytsqlsgvkd gdckkltsei
      301 faeietclne vrdeifislq pqlrctlgdm espvfafpll lklethiekl flysfswdfe
      361 csqcghqyqn rhmkslvtft nvipewhpln aahfgpcnnc nsksqirkmv lekvspifml
      421 hfveglpqnd lqhyafhfeg clyqitsviq yrannhfitw ildadgswle cddlkgpcse
      481 rhkkfevpas eihiviwerk isqvtdkeaa clplkktndq halsnekpvs ltscsvgdaa
      541 saetasvthp kdisvaprtl sqdtavthgd hllsgpkglv dnilpltlee tiqktasvsq
      601 lnseafllen kpvaentgil ktntllsqes lmassvsapc nekliqdqfv disfpsqvvn
      661 tnmqsvqlnt edtvntksvn ntdatgliqg vksveiekda qlkqfltpkt eqlkpervts
      721 qvsnlkkket tadsqtttsk slqnqslken qkkpfvgswv kglisrgasf mplcvsahnr
      781 ntitdlqpsv kgvnnfggfk tkginqkash vskkarksas kpppiskppa gppssngtaa
      841 hphahaasev leksgstscg aqlnhssygn gissanhedl vegqihklrl klrkklkaek
      901 kklaalmssp qsrtvrsenl eqvpqdgspn dcesiedlln elpypidias esacttvpgv
      961 slyssqthee ilaellsptp vstelsenge gdfrylgmgd shipppvpse fndvsqnthl
     1021 rqdhnycspt kknpcevqpd sltnnacvrt lnlespmktd ifdeffsssa lnalandtld
     1081 lphfdeylfe ny
//
LOCUS       XP_047285984            1092 aa            linear   PRI 05-AUG-2025
DEFINITION  SUMO-specific isopeptidase USPL1 isoform X1 [Homo sapiens].
ACCESSION   XP_047285984
VERSION     XP_047285984.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430028.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1092
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1092
                     /product="SUMO-specific isopeptidase USPL1 isoform X1"
                     /calculated_mol_wt=120309
     Region          226..498
                     /region_name="Peptidase_C98"
                     /note="Ubiquitin-specific peptidase-like, SUMO
                     isopeptidase; pfam15499"
                     /db_xref="CDD:464750"
     Region          572..1090
                     /region_name="DUF4650"
                     /note="Domain of unknown function (DUF4650); pfam15509"
                     /db_xref="CDD:464755"
     CDS             1..1092
                     /gene="USPL1"
                     /gene_synonym="bA121O19.1; C13orf22; D13S106E"
                     /coded_by="XM_047430028.1:268..3546"
                     /db_xref="GeneID:10208"
                     /db_xref="HGNC:HGNC:20294"
                     /db_xref="MIM:617470"
ORIGIN      
        1 mmdspkigng lpvigpgtdi gisslhmvgy lgknfdsakv psdeycpacr ekgklkalkt
       61 yrisfqesif lcedlqciyp lgskslnnli spdleechtp hkpqkrksle ssykdsllla
      121 nskktrnyia idggkvlnsk hngevydets snlpdssgqq npirtadsle rneileadtv
      181 dmattkdpat vdvsgtgrps pqnegctskl empleskcts fpqalcvqwk nayalcwldc
      241 ilsalvhsee lkntvtglcs keesifwrll tkynqantll ytsqlsgvkd gdckkltsei
      301 faeietclne vrdeifislq pqlrctlgdm espvfafpll lklethiekl flysfswdfe
      361 csqcghqyqn rhmkslvtft nvipewhpln aahfgpcnnc nsksqirkmv lekvspifml
      421 hfveglpqnd lqhyafhfeg clyqitsviq yrannhfitw ildadgswle cddlkgpcse
      481 rhkkfevpas eihiviwerk isqvtdkeaa clplkktndq halsnekpvs ltscsvgdaa
      541 saetasvthp kdisvaprtl sqdtavthgd hllsgpkglv dnilpltlee tiqktasvsq
      601 lnseafllen kpvaentgil ktntllsqes lmassvsapc nekliqdqfv disfpsqvvn
      661 tnmqsvqlnt edtvntksvn ntdatgliqg vksveiekda qlkqfltpkt eqlkpervts
      721 qvsnlkkket tadsqtttsk slqnqslken qkkpfvgswv kglisrgasf mplcvsahnr
      781 ntitdlqpsv kgvnnfggfk tkginqkash vskkarksas kpppiskppa gppssngtaa
      841 hphahaasev leksgstscg aqlnhssygn gissanhedl vegqihklrl klrkklkaek
      901 kklaalmssp qsrtvrsenl eqvpqdgspn dcesiedlln elpypidias esacttvpgv
      961 slyssqthee ilaellsptp vstelsenge gdfrylgmgd shipppvpse fndvsqnthl
     1021 rqdhnycspt kknpcevqpd sltnnacvrt lnlespmktd ifdeffsssa lnalandtld
     1081 lphfdeylfe ny
//
LOCUS       XP_006719814            1086 aa            linear   PRI 05-AUG-2025
DEFINITION  SUMO-specific isopeptidase USPL1 isoform X2 [Homo sapiens].
ACCESSION   XP_006719814
VERSION     XP_006719814.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006719751.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1086
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1086
                     /product="SUMO-specific isopeptidase USPL1 isoform X2"
                     /calculated_mol_wt=119692
     Region          220..492
                     /region_name="Peptidase_C98"
                     /note="Ubiquitin-specific peptidase-like, SUMO
                     isopeptidase; pfam15499"
                     /db_xref="CDD:464750"
     Region          566..1084
                     /region_name="DUF4650"
                     /note="Domain of unknown function (DUF4650); pfam15509"
                     /db_xref="CDD:464755"
     CDS             1..1086
                     /gene="USPL1"
                     /gene_synonym="bA121O19.1; C13orf22; D13S106E"
                     /coded_by="XM_006719751.5:206..3466"
                     /db_xref="GeneID:10208"
                     /db_xref="HGNC:HGNC:20294"
                     /db_xref="MIM:617470"
ORIGIN      
        1 mmdspkigng lpvigpgtdi gisslhmnfd sakvpsdeyc pacrekgklk alktyrisfq
       61 esiflcedlq ciyplgsksl nnlispdlee chtphkpqkr kslessykds lllanskktr
      121 nyiaidggkv lnskhngevy detssnlpds sgqqnpirta dslerneile adtvdmattk
      181 dpatvdvsgt grpspqnegc tsklemples kctsfpqalc vqwknayalc wldcilsalv
      241 hseelkntvt glcskeesif wrlltkynqa ntllytsqls gvkdgdckkl tseifaeiet
      301 clnevrdeif islqpqlrct lgdmespvfa fplllkleth ieklflysfs wdfecsqcgh
      361 qyqnrhmksl vtftnvipew hplnaahfgp cnncnsksqi rkmvlekvsp ifmlhfvegl
      421 pqndlqhyaf hfegclyqit sviqyrannh fitwildadg swlecddlkg pcserhkkfe
      481 vpaseihivi werkisqvtd keaaclplkk tndqhalsne kpvsltscsv gdaasaetas
      541 vthpkdisva prtlsqdtav thgdhllsgp kglvdnilpl tleetiqkta svsqlnseaf
      601 llenkpvaen tgilktntll sqeslmassv sapcnekliq dqfvdisfps qvvntnmqsv
      661 qlntedtvnt ksvnntdatg liqgvksvei ekdaqlkqfl tpkteqlkpe rvtsqvsnlk
      721 kkettadsqt ttskslqnqs lkenqkkpfv gswvkglisr gasfmplcvs ahnrntitdl
      781 qpsvkgvnnf ggfktkginq kashvskkar ksaskpppis kppagppssn gtaahphaha
      841 asevleksgs tscgaqlnhs sygngissan hedlvegqih klrlklrkkl kaekkklaal
      901 msspqsrtvr senleqvpqd gspndcesie dllnelpypi diasesactt vpgvslyssq
      961 theeilaell sptpvstels engegdfryl gmgdshippp vpsefndvsq nthlrqdhny
     1021 csptkknpce vqpdsltnna cvrtlnlesp mktdifdeff sssalnalan dtldlphfde
     1081 ylfeny
//
LOCUS       XP_047285985            1086 aa            linear   PRI 05-AUG-2025
DEFINITION  SUMO-specific isopeptidase USPL1 isoform X2 [Homo sapiens].
ACCESSION   XP_047285985
VERSION     XP_047285985.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430029.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1086
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1086
                     /product="SUMO-specific isopeptidase USPL1 isoform X2"
                     /calculated_mol_wt=119692
     Region          220..492
                     /region_name="Peptidase_C98"
                     /note="Ubiquitin-specific peptidase-like, SUMO
                     isopeptidase; pfam15499"
                     /db_xref="CDD:464750"
     Region          566..1084
                     /region_name="DUF4650"
                     /note="Domain of unknown function (DUF4650); pfam15509"
                     /db_xref="CDD:464755"
     CDS             1..1086
                     /gene="USPL1"
                     /gene_synonym="bA121O19.1; C13orf22; D13S106E"
                     /coded_by="XM_047430029.1:941..4201"
                     /db_xref="GeneID:10208"
                     /db_xref="HGNC:HGNC:20294"
                     /db_xref="MIM:617470"
ORIGIN      
        1 mmdspkigng lpvigpgtdi gisslhmnfd sakvpsdeyc pacrekgklk alktyrisfq
       61 esiflcedlq ciyplgsksl nnlispdlee chtphkpqkr kslessykds lllanskktr
      121 nyiaidggkv lnskhngevy detssnlpds sgqqnpirta dslerneile adtvdmattk
      181 dpatvdvsgt grpspqnegc tsklemples kctsfpqalc vqwknayalc wldcilsalv
      241 hseelkntvt glcskeesif wrlltkynqa ntllytsqls gvkdgdckkl tseifaeiet
      301 clnevrdeif islqpqlrct lgdmespvfa fplllkleth ieklflysfs wdfecsqcgh
      361 qyqnrhmksl vtftnvipew hplnaahfgp cnncnsksqi rkmvlekvsp ifmlhfvegl
      421 pqndlqhyaf hfegclyqit sviqyrannh fitwildadg swlecddlkg pcserhkkfe
      481 vpaseihivi werkisqvtd keaaclplkk tndqhalsne kpvsltscsv gdaasaetas
      541 vthpkdisva prtlsqdtav thgdhllsgp kglvdnilpl tleetiqkta svsqlnseaf
      601 llenkpvaen tgilktntll sqeslmassv sapcnekliq dqfvdisfps qvvntnmqsv
      661 qlntedtvnt ksvnntdatg liqgvksvei ekdaqlkqfl tpkteqlkpe rvtsqvsnlk
      721 kkettadsqt ttskslqnqs lkenqkkpfv gswvkglisr gasfmplcvs ahnrntitdl
      781 qpsvkgvnnf ggfktkginq kashvskkar ksaskpppis kppagppssn gtaahphaha
      841 asevleksgs tscgaqlnhs sygngissan hedlvegqih klrlklrkkl kaekkklaal
      901 msspqsrtvr senleqvpqd gspndcesie dllnelpypi diasesactt vpgvslyssq
      961 theeilaell sptpvstels engegdfryl gmgdshippp vpsefndvsq nthlrqdhny
     1021 csptkknpce vqpdsltnna cvrtlnlesp mktdifdeff sssalnalan dtldlphfde
     1081 ylfeny
//
LOCUS       XP_016875803            1054 aa            linear   PRI 05-AUG-2025
DEFINITION  SUMO-specific isopeptidase USPL1 isoform X3 [Homo sapiens].
ACCESSION   XP_016875803
VERSION     XP_016875803.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020314.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1054
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1054
                     /product="SUMO-specific isopeptidase USPL1 isoform X3"
                     /calculated_mol_wt=115955
     Region          226..460
                     /region_name="Peptidase_C98"
                     /note="Ubiquitin-specific peptidase-like, SUMO
                     isopeptidase; pfam15499"
                     /db_xref="CDD:464750"
     Region          534..1052
                     /region_name="DUF4650"
                     /note="Domain of unknown function (DUF4650); pfam15509"
                     /db_xref="CDD:464755"
     CDS             1..1054
                     /gene="USPL1"
                     /gene_synonym="bA121O19.1; C13orf22; D13S106E"
                     /coded_by="XM_017020314.3:206..3370"
                     /db_xref="GeneID:10208"
                     /db_xref="HGNC:HGNC:20294"
                     /db_xref="MIM:617470"
ORIGIN      
        1 mmdspkigng lpvigpgtdi gisslhmvgy lgknfdsakv psdeycpacr ekgklkalkt
       61 yrisfqesif lcedlqciyp lgskslnnli spdleechtp hkpqkrksle ssykdsllla
      121 nskktrnyia idggkvlnsk hngevydets snlpdssgqq npirtadsle rneileadtv
      181 dmattkdpat vdvsgtgrps pqnegctskl empleskcts fpqalcvqwk nayalcwldc
      241 ilsalvhsee lkntvtglcs keesifwrll tkynqantll ytsqlsgvkg dmespvfafp
      301 lllklethie klflysfswd fecsqcghqy qnrhmkslvt ftnvipewhp lnaahfgpcn
      361 ncnsksqirk mvlekvspif mlhfveglpq ndlqhyafhf egclyqitsv iqyrannhfi
      421 twildadgsw lecddlkgpc serhkkfevp aseihiviwe rkisqvtdke aaclplkktn
      481 dqhalsnekp vsltscsvgd aasaetasvt hpkdisvapr tlsqdtavth gdhllsgpkg
      541 lvdnilpltl eetiqktasv sqlnseafll enkpvaentg ilktntllsq eslmassvsa
      601 pcnekliqdq fvdisfpsqv vntnmqsvql ntedtvntks vnntdatgli qgvksveiek
      661 daqlkqfltp kteqlkperv tsqvsnlkkk ettadsqttt skslqnqslk enqkkpfvgs
      721 wvkglisrga sfmplcvsah nrntitdlqp svkgvnnfgg fktkginqka shvskkarks
      781 askpppiskp pagppssngt aahphahaas evleksgsts cgaqlnhssy gngissanhe
      841 dlvegqihkl rlklrkklka ekkklaalms spqsrtvrse nleqvpqdgs pndcesiedl
      901 lnelpypidi asesacttvp gvslyssqth eeilaellsp tpvstelsen gegdfrylgm
      961 gdshipppvp sefndvsqnt hlrqdhnycs ptkknpcevq pdsltnnacv rtlnlespmk
     1021 tdifdeffss salnalandt ldlphfdeyl feny
//
LOCUS       XP_016875804             873 aa            linear   PRI 05-AUG-2025
DEFINITION  SUMO-specific isopeptidase USPL1 isoform X4 [Homo sapiens].
ACCESSION   XP_016875804
VERSION     XP_016875804.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020315.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..873
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..873
                     /product="SUMO-specific isopeptidase USPL1 isoform X4"
                     /calculated_mol_wt=96038
     Region          45..279
                     /region_name="Peptidase_C98"
                     /note="Ubiquitin-specific peptidase-like, SUMO
                     isopeptidase; pfam15499"
                     /db_xref="CDD:464750"
     Region          353..871
                     /region_name="DUF4650"
                     /note="Domain of unknown function (DUF4650); pfam15509"
                     /db_xref="CDD:464755"
     CDS             1..873
                     /gene="USPL1"
                     /gene_synonym="bA121O19.1; C13orf22; D13S106E"
                     /coded_by="XM_017020315.2:582..3203"
                     /db_xref="GeneID:10208"
                     /db_xref="HGNC:HGNC:20294"
                     /db_xref="MIM:617470"
ORIGIN      
        1 mattkdpatv dvsgtgrpsp qnegctskle mpleskctsf pqalcvqwkn ayalcwldci
       61 lsalvhseel kntvtglcsk eesifwrllt kynqantlly tsqlsgvkgd mespvfafpl
      121 llklethiek lflysfswdf ecsqcghqyq nrhmkslvtf tnvipewhpl naahfgpcnn
      181 cnsksqirkm vlekvspifm lhfveglpqn dlqhyafhfe gclyqitsvi qyrannhfit
      241 wildadgswl ecddlkgpcs erhkkfevpa seihiviwer kisqvtdkea aclplkktnd
      301 qhalsnekpv sltscsvgda asaetasvth pkdisvaprt lsqdtavthg dhllsgpkgl
      361 vdnilpltle etiqktasvs qlnseaflle nkpvaentgi lktntllsqe slmassvsap
      421 cnekliqdqf vdisfpsqvv ntnmqsvqln tedtvntksv nntdatgliq gvksveiekd
      481 aqlkqfltpk teqlkpervt sqvsnlkkke ttadsqttts kslqnqslke nqkkpfvgsw
      541 vkglisrgas fmplcvsahn rntitdlqps vkgvnnfggf ktkginqkas hvskkarksa
      601 skpppiskpp agppssngta ahphahaase vleksgstsc gaqlnhssyg ngissanhed
      661 lvegqihklr lklrkklkae kkklaalmss pqsrtvrsen leqvpqdgsp ndcesiedll
      721 nelpypidia sesacttvpg vslyssqthe eilaellspt pvstelseng egdfrylgmg
      781 dshipppvps efndvsqnth lrqdhnycsp tkknpcevqp dsltnnacvr tlnlespmkt
      841 difdeffsss alnalandtl dlphfdeylf eny
//
LOCUS       XP_047285986             911 aa            linear   PRI 05-AUG-2025
DEFINITION  SUMO-specific isopeptidase USPL1 isoform X5 [Homo sapiens].
ACCESSION   XP_047285986
VERSION     XP_047285986.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430030.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..911
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..911
                     /product="SUMO-specific isopeptidase USPL1 isoform X5"
                     /calculated_mol_wt=100392
     Region          45..317
                     /region_name="Peptidase_C98"
                     /note="Ubiquitin-specific peptidase-like, SUMO
                     isopeptidase; pfam15499"
                     /db_xref="CDD:464750"
     Region          391..909
                     /region_name="DUF4650"
                     /note="Domain of unknown function (DUF4650); pfam15509"
                     /db_xref="CDD:464755"
     CDS             1..911
                     /gene="USPL1"
                     /gene_synonym="bA121O19.1; C13orf22; D13S106E"
                     /coded_by="XM_047430030.1:1317..4052"
                     /db_xref="GeneID:10208"
                     /db_xref="HGNC:HGNC:20294"
                     /db_xref="MIM:617470"
ORIGIN      
        1 mattkdpatv dvsgtgrpsp qnegctskle mpleskctsf pqalcvqwkn ayalcwldci
       61 lsalvhseel kntvtglcsk eesifwrllt kynqantlly tsqlsgvkdg dckkltseif
      121 aeietclnev rdeifislqp qlrctlgdme spvfafplll klethieklf lysfswdfec
      181 sqcghqyqnr hmkslvtftn vipewhplna ahfgpcnncn sksqirkmvl ekvspifmlh
      241 fveglpqndl qhyafhfegc lyqitsviqy rannhfitwi ldadgswlec ddlkgpcser
      301 hkkfevpase ihiviwerki sqvtdkeaac lplkktndqh alsnekpvsl tscsvgdaas
      361 aetasvthpk disvaprtls qdtavthgdh llsgpkglvd nilpltleet iqktasvsql
      421 nseafllenk pvaentgilk tntllsqesl massvsapcn ekliqdqfvd isfpsqvvnt
      481 nmqsvqlnte dtvntksvnn tdatgliqgv ksveiekdaq lkqfltpkte qlkpervtsq
      541 vsnlkkkett adsqtttsks lqnqslkenq kkpfvgswvk glisrgasfm plcvsahnrn
      601 titdlqpsvk gvnnfggfkt kginqkashv skkarksask pppiskppag ppssngtaah
      661 phahaasevl eksgstscga qlnhssygng issanhedlv egqihklrlk lrkklkaekk
      721 klaalmsspq srtvrsenle qvpqdgspnd cesiedllne lpypidiase sacttvpgvs
      781 lyssqtheei laellsptpv stelsengeg dfrylgmgds hipppvpsef ndvsqnthlr
      841 qdhnycsptk knpcevqpds ltnnacvrtl nlespmktdi fdeffsssal nalandtldl
      901 phfdeylfen y
//
LOCUS       XP_047285987             911 aa            linear   PRI 05-AUG-2025
DEFINITION  SUMO-specific isopeptidase USPL1 isoform X5 [Homo sapiens].
ACCESSION   XP_047285987
VERSION     XP_047285987.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430031.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..911
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..911
                     /product="SUMO-specific isopeptidase USPL1 isoform X5"
                     /calculated_mol_wt=100392
     Region          45..317
                     /region_name="Peptidase_C98"
                     /note="Ubiquitin-specific peptidase-like, SUMO
                     isopeptidase; pfam15499"
                     /db_xref="CDD:464750"
     Region          391..909
                     /region_name="DUF4650"
                     /note="Domain of unknown function (DUF4650); pfam15509"
                     /db_xref="CDD:464755"
     CDS             1..911
                     /gene="USPL1"
                     /gene_synonym="bA121O19.1; C13orf22; D13S106E"
                     /coded_by="XM_047430031.1:644..3379"
                     /db_xref="GeneID:10208"
                     /db_xref="HGNC:HGNC:20294"
                     /db_xref="MIM:617470"
ORIGIN      
        1 mattkdpatv dvsgtgrpsp qnegctskle mpleskctsf pqalcvqwkn ayalcwldci
       61 lsalvhseel kntvtglcsk eesifwrllt kynqantlly tsqlsgvkdg dckkltseif
      121 aeietclnev rdeifislqp qlrctlgdme spvfafplll klethieklf lysfswdfec
      181 sqcghqyqnr hmkslvtftn vipewhplna ahfgpcnncn sksqirkmvl ekvspifmlh
      241 fveglpqndl qhyafhfegc lyqitsviqy rannhfitwi ldadgswlec ddlkgpcser
      301 hkkfevpase ihiviwerki sqvtdkeaac lplkktndqh alsnekpvsl tscsvgdaas
      361 aetasvthpk disvaprtls qdtavthgdh llsgpkglvd nilpltleet iqktasvsql
      421 nseafllenk pvaentgilk tntllsqesl massvsapcn ekliqdqfvd isfpsqvvnt
      481 nmqsvqlnte dtvntksvnn tdatgliqgv ksveiekdaq lkqfltpkte qlkpervtsq
      541 vsnlkkkett adsqtttsks lqnqslkenq kkpfvgswvk glisrgasfm plcvsahnrn
      601 titdlqpsvk gvnnfggfkt kginqkashv skkarksask pppiskppag ppssngtaah
      661 phahaasevl eksgstscga qlnhssygng issanhedlv egqihklrlk lrkklkaekk
      721 klaalmsspq srtvrsenle qvpqdgspnd cesiedllne lpypidiase sacttvpgvs
      781 lyssqtheei laellsptpv stelsengeg dfrylgmgds hipppvpsef ndvsqnthlr
      841 qdhnycsptk knpcevqpds ltnnacvrtl nlespmktdi fdeffsssal nalandtldl
      901 phfdeylfen y
//
LOCUS       XP_047285988             237 aa            linear   PRI 05-AUG-2025
DEFINITION  SUMO-specific isopeptidase USPL1 isoform X6 [Homo sapiens].
ACCESSION   XP_047285988
VERSION     XP_047285988.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430032.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..237
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..237
                     /product="SUMO-specific isopeptidase USPL1 isoform X6"
                     /calculated_mol_wt=26686
     Region          45..>232
                     /region_name="Peptidase_C98"
                     /note="Ubiquitin-specific peptidase-like, SUMO
                     isopeptidase; pfam15499"
                     /db_xref="CDD:464750"
     CDS             1..237
                     /gene="USPL1"
                     /gene_synonym="bA121O19.1; C13orf22; D13S106E"
                     /coded_by="XM_047430032.1:582..1295"
                     /db_xref="GeneID:10208"
                     /db_xref="HGNC:HGNC:20294"
                     /db_xref="MIM:617470"
ORIGIN      
        1 mattkdpatv dvsgtgrpsp qnegctskle mpleskctsf pqalcvqwkn ayalcwldci
       61 lsalvhseel kntvtglcsk eesifwrllt kynqantlly tsqlsgvkdg dckkltseif
      121 aeietclnev rdeifislqp qlrctlgdme spvfafplll klethieklf lysfswdfec
      181 sqcghqyqnr hmkslvtftn vipewhplna ahfgpcnncn sksqirkmvl ekklagm
//
LOCUS       XP_047285989             404 aa            linear   PRI 05-AUG-2025
DEFINITION  cyclin-dependent kinase 8 isoform X1 [Homo sapiens].
ACCESSION   XP_047285989
VERSION     XP_047285989.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430033.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 46% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..404
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..404
                     /product="cyclin-dependent kinase 8 isoform X1"
                     /calculated_mol_wt=46217
     Region          1..275
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..404
                     /gene="CDK8"
                     /gene_synonym="IDDHBA; K35"
                     /coded_by="XM_047430033.1:744..1958"
                     /db_xref="GeneID:1024"
                     /db_xref="HGNC:HGNC:1779"
                     /db_xref="MIM:603184"
ORIGIN      
        1 msacreiall relkhpnvis lqkvflshad rkvwllfdya ehdlwhiikf hraskankkp
       61 vqlprgmvks llyqildgih ylhanwvlhr dlkpanilvm gegpergrvk iadmgfarlf
      121 nsplkpladl dpvvvtfwyr apelllgarh ytkaidiwai gcifaellts epifhcrqed
      181 iktsnpyhhd qldrifnvmg fpadkdwedi kkmpehstlm kdfrrntytn cslikymekh
      241 kvkpdskafh llqklltmdp ikritseqam qdpyfledpl ptsdvfagcq ipypkreflt
      301 eeepddkgdk knqqqqqgnn htngtghpgn qdsshtqgpp lkkvrvvppt ttsgglimts
      361 dyqrsnphaa ypnpgpstsq pqssmgysat sqqppqyshq thry
//
LOCUS       XP_011533167             291 aa            linear   PRI 05-AUG-2025
DEFINITION  cyclin-dependent kinase 8 isoform X2 [Homo sapiens].
ACCESSION   XP_011533167
VERSION     XP_011533167.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534865.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..291
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..291
                     /product="cyclin-dependent kinase 8 isoform X2"
                     /calculated_mol_wt=33070
     Region          <1..162
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..291
                     /gene="CDK8"
                     /gene_synonym="IDDHBA; K35"
                     /coded_by="XM_011534865.3:1069..1944"
                     /db_xref="GeneID:1024"
                     /db_xref="HGNC:HGNC:1779"
                     /db_xref="MIM:603184"
ORIGIN      
        1 mgfarlfnsp lkpladldpv vvtfwyrape lllgarhytk aidiwaigci faelltsepi
       61 fhcrqedikt snpyhhdqld rifnvmgfpa dkdwedikkm pehstlmkdf rrntytncsl
      121 ikymekhkvk pdskafhllq klltmdpikr itseqamqdp yfledplpts dvfagcqipy
      181 pkreflteee pddkgdkknq qqqqgnnhtn gtghpgnqds shtqgpplkk vrvvppttts
      241 gglimtsdyq rsnphaaypn pgpstsqpqs smgysatsqq ppqyshqthr y
//
LOCUS       XP_047285990            1282 aa            linear   PRI 05-AUG-2025
DEFINITION  ATP-binding cassette sub-family C member 4 isoform X1 [Homo
            sapiens].
ACCESSION   XP_047285990
VERSION     XP_047285990.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430034.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1282
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1282
                     /product="ATP-binding cassette sub-family C member 4
                     isoform X1"
                     /calculated_mol_wt=144170
     Region          8..1234
                     /region_name="PLN03130"
                     /note="ABC transporter C family member; Provisional"
                     /db_xref="CDD:215595"
     CDS             1..1282
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /coded_by="XM_047430034.1:163..4011"
                     /db_xref="GeneID:10257"
                     /db_xref="HGNC:HGNC:55"
                     /db_xref="MIM:605250"
ORIGIN      
        1 mysvlpedrs qhlgeelqgf wdkevlraen daqkpsltra iikcywksyl vlgiftliee
       61 sakviqpifl gkiinyfeny dpmdsvalnt ayayatvltf ctlilailhh lyfyhvqcag
      121 mrlrvamchm iyrkalrlsn mamgktttgq ivnllsndvn kfdqvtvflh flwagplqai
      181 avtallwmei gisclagmav liillplqsc fgklfsslrs ktatftdari rtmnevitgi
      241 riikmyawek sfsnlitnlr kkeiskilrs sclrgmnlas ffsaskiivf vtfttyvllg
      301 svitasrvfv avtlygavrl tvtlffpsai ervseaivsi rriqtfllld eisqrnrqlp
      361 sdgkkmvhvq dftafwdkas etptlqglsf tvrpgellav vgpvgagkss llsavlgela
      421 pshglvsvhg riayvsqqpw vfsgtlrsni lfgkkyeker yekvikacal kkdlqlledg
      481 dltvigdrgt tlsggqkarv nlaravyqda diyllddpls avdaevsrhl felcicqilh
      541 ekitilvthq lqylkaasqi lilkdgkmvq kgtyteflks gidfgsllkk dneeseqppv
      601 pgtptlrnrt fsessvwsqq ssrpslkdga lesqdtenvp vtlseenrse gkvgfqaykn
      661 yfragahwiv fiflillnta aqvayvlqdw wlsywankqs mlnvtvnggg nvtekldlnw
      721 ylgiysgltv atvlfgiars llvfyvlvns sqtlhnkmfe silkapvlff drnpigriln
      781 rfskdighld dllpltfldf iqtllqvvgv vsvavavipw iaiplvplgi ififlrryfl
      841 etsrdvkrle sttrspvfsh lssslqglwt iraykaeerc qelfdahqdl hseawflflt
      901 tsrwfavrld aicamfviiv afgslilakt ldagqvglal syaltlmgmf qwcvrqsaev
      961 enmmisverv ieytdlekea pweyqkrppp awphegviif dnvnfmyspg gplvlkhlta
     1021 liksqekvgi vgrtgagkss lisalfrlse pegkiwidki ltteiglhdl rkkmsiipqe
     1081 pvlftgtmrk nldpfnehtd eelwnalqev qlketiedlp gkmdtelaes gsnfsvgqrq
     1141 lvclarailr knqiliidea tanvdprtde liqkkirekf ahctvltiah rlntiidsdk
     1201 imvldsgrlk eydepyvllq nkeslfykmv qqlgkaeaaa ltetakqvyf krnyphight
     1261 dhmvtntsng qpstltifet al
//
LOCUS       XP_047285991            1142 aa            linear   PRI 05-AUG-2025
DEFINITION  ATP-binding cassette sub-family C member 4 isoform X2 [Homo
            sapiens].
ACCESSION   XP_047285991
VERSION     XP_047285991.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430035.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1142
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1142
                     /product="ATP-binding cassette sub-family C member 4
                     isoform X2"
                     /calculated_mol_wt=127901
     Region          <6..1094
                     /region_name="MRP_assoc_pro"
                     /note="multi drug resistance-associated protein (MRP);
                     TIGR00957"
                     /db_xref="CDD:188098"
     CDS             1..1142
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /coded_by="XM_047430035.1:794..4222"
                     /db_xref="GeneID:10257"
                     /db_xref="HGNC:HGNC:55"
                     /db_xref="MIM:605250"
ORIGIN      
        1 mamgktttgq ivnllsndvn kfdqvtvflh flwagplqai avtallwmei gisclagmav
       61 liillplqsc fgklfsslrs ktatftdari rtmnevitgi riikmyawek sfsnlitnlr
      121 kkeiskilrs sclrgmnlas ffsaskiivf vtfttyvllg svitasrvfv avtlygavrl
      181 tvtlffpsai ervseaivsi rriqtfllld eisqrnrqlp sdgkkmvhvq dftafwdkas
      241 etptlqglsf tvrpgellav vgpvgagkss llsavlgela pshglvsvhg riayvsqqpw
      301 vfsgtlrsni lfgkkyeker yekvikacal kkdlqlledg dltvigdrgt tlsggqkarv
      361 nlaravyqda diyllddpls avdaevsrhl felcicqilh ekitilvthq lqylkaasqi
      421 lilkdgkmvq kgtyteflks gidfgsllkk dneeseqppv pgtptlrnrt fsessvwsqq
      481 ssrpslkdga lesqdtenvp vtlseenrse gkvgfqaykn yfragahwiv fiflillnta
      541 aqvayvlqdw wlsywankqs mlnvtvnggg nvtekldlnw ylgiysgltv atvlfgiars
      601 llvfyvlvns sqtlhnkmfe silkapvlff drnpigriln rfskdighld dllpltfldf
      661 iqtllqvvgv vsvavavipw iaiplvplgi ififlrryfl etsrdvkrle sttrspvfsh
      721 lssslqglwt iraykaeerc qelfdahqdl hseawflflt tsrwfavrld aicamfviiv
      781 afgslilakt ldagqvglal syaltlmgmf qwcvrqsaev enmmisverv ieytdlekea
      841 pweyqkrppp awphegviif dnvnfmyspg gplvlkhlta liksqekvgi vgrtgagkss
      901 lisalfrlse pegkiwidki ltteiglhdl rkkmsiipqe pvlftgtmrk nldpfnehtd
      961 eelwnalqev qlketiedlp gkmdtelaes gsnfsvgqrq lvclarailr knqiliidea
     1021 tanvdprtde liqkkirekf ahctvltiah rlntiidsdk imvldsgrlk eydepyvllq
     1081 nkeslfykmv qqlgkaeaaa ltetakqvyf krnyphight dhmvtntsng qpstltifet
     1141 al
//
LOCUS       XP_016875809             830 aa            linear   PRI 05-AUG-2025
DEFINITION  ATP-binding cassette sub-family C member 4 isoform X3 [Homo
            sapiens].
ACCESSION   XP_016875809
VERSION     XP_016875809.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020320.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..830
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..830
                     /product="ATP-binding cassette sub-family C member 4
                     isoform X3"
                     /calculated_mol_wt=93347
     Region          12..>818
                     /region_name="PLN03130"
                     /note="ABC transporter C family member; Provisional"
                     /db_xref="CDD:215595"
     Region          94..386
                     /region_name="ABC_6TM_MRP4_D1_like"
                     /note="Six-transmembrane helical domain 1 (TMD1) of
                     multidrug resistance-associated protein 4 (MRP4) and
                     similar proteins; cd18593"
                     /db_xref="CDD:350037"
     Region          94..117
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:350037"
     Region          133..181
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:350037"
     Region          188..233
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:350037"
     Region          234..282
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:350037"
     Region          294..338
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:350037"
     Region          351..385
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:350037"
     CDS             1..830
                     /gene="ABCC4"
                     /gene_synonym="MOAT-B; MOATB; MRP4"
                     /coded_by="XM_017020320.3:138..2630"
                     /db_xref="GeneID:10257"
                     /db_xref="HGNC:HGNC:55"
                     /db_xref="MIM:605250"
ORIGIN      
        1 mlpvyqevkp nplqdanlcs rvffwwlnpl fkighkrrle eddmysvlpe drsqhlgeel
       61 qgfwdkevlr aendaqkpsl traiikcywk sylvlgiftl ieesakviqp iflgkiinyf
      121 enydpmdsva lntayayatv ltfctlilai lhhlyfyhvq cagmrlrvam chmiyrkalr
      181 lsnmamgktt tgqivnllsn dvnkfdqvtv flhflwagpl qaiavtallw meigisclag
      241 mavliillpl qscfgklfss lrsktatftd arirtmnevi tgiriikmya weksfsnlit
      301 nlrkkeiski lrssclrgmn lasffsaski ivfvtfttyv llgsvitasr vfvavtlyga
      361 vrltvtlffp saiervseai vsirriqtfl lldeisqrnr qlpsdgkkmv hvqdftafwd
      421 kasetptlqg lsftvrpgel lavvgpvgag kssllsavlg elapshglvs vhgriayvsq
      481 qpwvfsgtlr snilfgkkye keryekvika calkkdlqll edgdltvigd rgttlsggqk
      541 arvnlaravy qdadiylldd plsavdaevs rhlfelcicq ilhekitilv thqlqylkaa
      601 sqililkdgk mvqkgtytef lksgidfgsl lkkdneeseq ppvpgtptlr nrtfsessvw
      661 sqqssrpslk dgalesqdte nvpvtlseen rsegkvgfqa yknyfragah wivfiflill
      721 ntaaqvayvl qdwwlsywan kqsmlnvtvn gggnvtekld lnwylgiysg ltvatvlfgi
      781 arsllvfyvl vnssqtlhnk mfesilkapv lffdrnpive tgfylllvlr
//
LOCUS       XP_005268350             818 aa            linear   PRI 05-AUG-2025
DEFINITION  gamma-tubulin complex component 3 isoform X1 [Homo sapiens].
ACCESSION   XP_005268350
VERSION     XP_005268350.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005268293.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..818
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..818
                     /product="gamma-tubulin complex component 3 isoform X1"
                     /calculated_mol_wt=92972
     Region          251..552
                     /region_name="GCP_N_terminal"
                     /note="Gamma tubulin complex component N-terminal;
                     pfam17681"
                     /db_xref="CDD:465456"
     Region          555..814
                     /region_name="GCP_C_terminal"
                     /note="Gamma tubulin complex component C-terminal;
                     pfam04130"
                     /db_xref="CDD:461187"
     CDS             1..818
                     /gene="TUBGCP3"
                     /gene_synonym="104p; ALP6; GCP3; Grip104; SPBC98; Spc98;
                     Spc98p"
                     /coded_by="XM_005268293.3:174..2630"
                     /db_xref="GeneID:10426"
                     /db_xref="HGNC:HGNC:18598"
                     /db_xref="MIM:617818"
ORIGIN      
        1 matpdqkspn vllqnlccri lgrseadvaq qfqyavrvig snfaptverd eflvaekikk
       61 elirqrread aalfselhrk lhsqgvlknk wsilylllsl sedprrqpsk vssyatlfaq
      121 alprdahstp yyyarpqtlp lsyqdrsaqs aqssgsvgss gissiglcal sgpapapqsl
      181 lpgqsnqapg vgdclrqqlg srlawtltan qpssqattsk gvpsavsrnm trsrregdtg
      241 gtmeiteaal vrdilyvfqg idgknikmnn tencykvegk anlsrslrdt avrlselgwl
      301 hnkirrytdq rsldrsfglv gqsfcaalhq elreyyrlls vlhsqlqled dqgvnlgles
      361 sltlrrllvw tydpkirlkt laalvdhcqg rkggelasav haytktgdpy mrslvqhils
      421 lvshpvlsfl yrwiydgele dtyheffvas dptvktdrlw hdkytlrksm ipsfmtmdqs
      481 rkvlligksi nflhqvchdq tpttkmiavt ksaespqdaa dlftdlenaf qgkidaayfe
      541 tskylldvln kkyslldhmq amrrylllgq gdfirhlmdl lkpelvrpat tlyqhnltgi
      601 letavratna qfdspeilrr ldvrllevsp gdtgwdvfsl dyhvdgpiat vftrecmshy
      661 lrvfnflwra krmeyiltdi rkghmcnakl lrnmpefsgv lhqchilase mvhfihqmqy
      721 yitfevlecs wdelwnkvqq aqdldhiiaa hevfldtiis rclldsdsra llnqlravfd
      781 qiielqnaqd aiyraaleel qrrlqfeekk kqreietg
//
LOCUS       XP_011535764             807 aa            linear   PRI 05-AUG-2025
DEFINITION  gamma-tubulin complex component 3 isoform X2 [Homo sapiens].
ACCESSION   XP_011535764
VERSION     XP_011535764.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537462.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..807
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..807
                     /product="gamma-tubulin complex component 3 isoform X2"
                     /calculated_mol_wt=92032
     Region          251..452
                     /region_name="GCP_N_terminal"
                     /note="Gamma tubulin complex component N-terminal;
                     pfam17681"
                     /db_xref="CDD:465456"
     Region          455..786
                     /region_name="GCP_C_terminal"
                     /note="Gamma tubulin complex component C-terminal;
                     pfam04130"
                     /db_xref="CDD:461187"
     CDS             1..807
                     /gene="TUBGCP3"
                     /gene_synonym="104p; ALP6; GCP3; Grip104; SPBC98; Spc98;
                     Spc98p"
                     /coded_by="XM_011537462.3:174..2597"
                     /db_xref="GeneID:10426"
                     /db_xref="HGNC:HGNC:18598"
                     /db_xref="MIM:617818"
ORIGIN      
        1 matpdqkspn vllqnlccri lgrseadvaq qfqyavrvig snfaptverd eflvaekikk
       61 elirqrread aalfselhrk lhsqgvlknk wsilylllsl sedprrqpsk vssyatlfaq
      121 alprdahstp yyyarpqtlp lsyqdrsaqs aqssgsvgss gissiglcal sgpapapqsl
      181 lpgqsnqapg vgdclrqqlg srlawtltan qpssqattsk gvpsavsrnm trsrregdtg
      241 gtmeiteaal vrdilyvfqg idgknikmnn tencykvegk anlsrslrdt avrlselgwl
      301 hnkirrytdq rsldrsfglv gqsfcaalhq elreyyrlls vlhsqffvas dptvktdrlw
      361 hdkytlrksm ipsfmtmdqs rkvlligksi nflhqvchdq tpttkmiavt ksaespqdaa
      421 dlftdlenaf qgkidaayfe tskylldvln kkyslldhmq amrrylllgq gdfirhlmdl
      481 lkpelvrpat tlyqhnltgi letavratna qfdspeilrr ldvrllevsp gdtgwdvfsl
      541 dyhvdgpiat vftrecmshy lrvfnflwra krmeyiltdi rkghmcnakl lrnmpefsgv
      601 lhqchilase mvhfihqmqy yitfevlecs wdelwnkvqq aqdldhiiaa hevfldtiis
      661 rclldsdsra llnqlravfd qiielqnaqd aiyraaleel qrrlqfeekk kqreiegqwg
      721 vtaaeeeeen krigefkesi pkmcsqlril thfyqgivqq flvllttssd eslrflsfrl
      781 dfnehykare prlrvslgtr grrssht
//
LOCUS       XP_047285992             724 aa            linear   PRI 05-AUG-2025
DEFINITION  gamma-tubulin complex component 3 isoform X3 [Homo sapiens].
ACCESSION   XP_047285992
VERSION     XP_047285992.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430036.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..724
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..724
                     /product="gamma-tubulin complex component 3 isoform X3"
                     /calculated_mol_wt=82347
     Region          251..452
                     /region_name="GCP_N_terminal"
                     /note="Gamma tubulin complex component N-terminal;
                     pfam17681"
                     /db_xref="CDD:465456"
     Region          455..714
                     /region_name="GCP_C_terminal"
                     /note="Gamma tubulin complex component C-terminal;
                     pfam04130"
                     /db_xref="CDD:461187"
     CDS             1..724
                     /gene="TUBGCP3"
                     /gene_synonym="104p; ALP6; GCP3; Grip104; SPBC98; Spc98;
                     Spc98p"
                     /coded_by="XM_047430036.1:174..2348"
                     /db_xref="GeneID:10426"
                     /db_xref="HGNC:HGNC:18598"
                     /db_xref="MIM:617818"
ORIGIN      
        1 matpdqkspn vllqnlccri lgrseadvaq qfqyavrvig snfaptverd eflvaekikk
       61 elirqrread aalfselhrk lhsqgvlknk wsilylllsl sedprrqpsk vssyatlfaq
      121 alprdahstp yyyarpqtlp lsyqdrsaqs aqssgsvgss gissiglcal sgpapapqsl
      181 lpgqsnqapg vgdclrqqlg srlawtltan qpssqattsk gvpsavsrnm trsrregdtg
      241 gtmeiteaal vrdilyvfqg idgknikmnn tencykvegk anlsrslrdt avrlselgwl
      301 hnkirrytdq rsldrsfglv gqsfcaalhq elreyyrlls vlhsqffvas dptvktdrlw
      361 hdkytlrksm ipsfmtmdqs rkvlligksi nflhqvchdq tpttkmiavt ksaespqdaa
      421 dlftdlenaf qgkidaayfe tskylldvln kkyslldhmq amrrylllgq gdfirhlmdl
      481 lkpelvrpat tlyqhnltgi letavratna qfdspeilrr ldvrllevsp gdtgwdvfsl
      541 dyhvdgpiat vftrecmshy lrvfnflwra krmeyiltdi rkghmcnakl lrnmpefsgv
      601 lhqchilase mvhfihqmqy yitfevlecs wdelwnkvqq aqdldhiiaa hevfldtiis
      661 rclldsdsra llnqlravfd qiielqnaqd aiyraaleel qrrlqfeekk kqreievemc
      721 lycv
//
LOCUS       XP_047285993             718 aa            linear   PRI 05-AUG-2025
DEFINITION  gamma-tubulin complex component 3 isoform X4 [Homo sapiens].
ACCESSION   XP_047285993
VERSION     XP_047285993.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430037.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..718
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..718
                     /product="gamma-tubulin complex component 3 isoform X4"
                     /calculated_mol_wt=81564
     Region          251..452
                     /region_name="GCP_N_terminal"
                     /note="Gamma tubulin complex component N-terminal;
                     pfam17681"
                     /db_xref="CDD:465456"
     Region          455..714
                     /region_name="GCP_C_terminal"
                     /note="Gamma tubulin complex component C-terminal;
                     pfam04130"
                     /db_xref="CDD:461187"
     CDS             1..718
                     /gene="TUBGCP3"
                     /gene_synonym="104p; ALP6; GCP3; Grip104; SPBC98; Spc98;
                     Spc98p"
                     /coded_by="XM_047430037.1:174..2330"
                     /db_xref="GeneID:10426"
                     /db_xref="HGNC:HGNC:18598"
                     /db_xref="MIM:617818"
ORIGIN      
        1 matpdqkspn vllqnlccri lgrseadvaq qfqyavrvig snfaptverd eflvaekikk
       61 elirqrread aalfselhrk lhsqgvlknk wsilylllsl sedprrqpsk vssyatlfaq
      121 alprdahstp yyyarpqtlp lsyqdrsaqs aqssgsvgss gissiglcal sgpapapqsl
      181 lpgqsnqapg vgdclrqqlg srlawtltan qpssqattsk gvpsavsrnm trsrregdtg
      241 gtmeiteaal vrdilyvfqg idgknikmnn tencykvegk anlsrslrdt avrlselgwl
      301 hnkirrytdq rsldrsfglv gqsfcaalhq elreyyrlls vlhsqffvas dptvktdrlw
      361 hdkytlrksm ipsfmtmdqs rkvlligksi nflhqvchdq tpttkmiavt ksaespqdaa
      421 dlftdlenaf qgkidaayfe tskylldvln kkyslldhmq amrrylllgq gdfirhlmdl
      481 lkpelvrpat tlyqhnltgi letavratna qfdspeilrr ldvrllevsp gdtgwdvfsl
      541 dyhvdgpiat vftrecmshy lrvfnflwra krmeyiltdi rkghmcnakl lrnmpefsgv
      601 lhqchilase mvhfihqmqy yitfevlecs wdelwnkvqq aqdldhiiaa hevfldtiis
      661 rclldsdsra llnqlravfd qiielqnaqd aiyraaleel qrrlqfeekk kqreietg
//
LOCUS       XP_016875812             678 aa            linear   PRI 05-AUG-2025
DEFINITION  gamma-tubulin complex component 3 isoform X5 [Homo sapiens].
ACCESSION   XP_016875812
VERSION     XP_016875812.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020323.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..678
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..678
                     /product="gamma-tubulin complex component 3 isoform X5"
                     /calculated_mol_wt=78619
     Region          22..323
                     /region_name="GCP_N_terminal"
                     /note="Gamma tubulin complex component N-terminal;
                     pfam17681"
                     /db_xref="CDD:465456"
     Region          326..657
                     /region_name="GCP_C_terminal"
                     /note="Gamma tubulin complex component C-terminal;
                     pfam04130"
                     /db_xref="CDD:461187"
     CDS             1..678
                     /gene="TUBGCP3"
                     /gene_synonym="104p; ALP6; GCP3; Grip104; SPBC98; Spc98;
                     Spc98p"
                     /coded_by="XM_017020323.3:814..2850"
                     /db_xref="GeneID:10426"
                     /db_xref="HGNC:HGNC:18598"
                     /db_xref="MIM:617818"
ORIGIN      
        1 mtrsrregdt ggtmeiteaa lvrdilyvfq gidgknikmn ntencykveg kanlsrslrd
       61 tavrlselgw lhnkirrytd qrsldrsfgl vgqsfcaalh qelreyyrll svlhsqlqle
      121 ddqgvnlgle ssltlrrllv wtydpkirlk tlaalvdhcq grkggelasa vhaytktgdp
      181 ymrslvqhil slvshpvlsf lyrwiydgel edtyheffva sdptvktdrl whdkytlrks
      241 mipsfmtmdq srkvlligks inflhqvchd qtpttkmiav tksaespqda adlftdlena
      301 fqgkidaayf etskylldvl nkkyslldhm qamrrylllg qgdfirhlmd llkpelvrpa
      361 ttlyqhnltg iletavratn aqfdspeilr rldvrllevs pgdtgwdvfs ldyhvdgpia
      421 tvftrecmsh ylrvfnflwr akrmeyiltd irkghmcnak llrnmpefsg vlhqchilas
      481 emvhfihqmq yyitfevlec swdelwnkvq qaqdldhiia ahevfldtii srclldsdsr
      541 allnqlravf dqiielqnaq daiyraalee lqrrlqfeek kkqreiegqw gvtaaeeeee
      601 nkrigefkes ipkmcsqlri lthfyqgivq qflvllttss deslrflsfr ldfnehykar
      661 eprlrvslgt rgrrssht
//
LOCUS       XP_047285994             678 aa            linear   PRI 05-AUG-2025
DEFINITION  gamma-tubulin complex component 3 isoform X5 [Homo sapiens].
ACCESSION   XP_047285994
VERSION     XP_047285994.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430038.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..678
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..678
                     /product="gamma-tubulin complex component 3 isoform X5"
                     /calculated_mol_wt=78619
     Region          22..323
                     /region_name="GCP_N_terminal"
                     /note="Gamma tubulin complex component N-terminal;
                     pfam17681"
                     /db_xref="CDD:465456"
     Region          326..657
                     /region_name="GCP_C_terminal"
                     /note="Gamma tubulin complex component C-terminal;
                     pfam04130"
                     /db_xref="CDD:461187"
     CDS             1..678
                     /gene="TUBGCP3"
                     /gene_synonym="104p; ALP6; GCP3; Grip104; SPBC98; Spc98;
                     Spc98p"
                     /coded_by="XM_047430038.1:927..2963"
                     /db_xref="GeneID:10426"
                     /db_xref="HGNC:HGNC:18598"
                     /db_xref="MIM:617818"
ORIGIN      
        1 mtrsrregdt ggtmeiteaa lvrdilyvfq gidgknikmn ntencykveg kanlsrslrd
       61 tavrlselgw lhnkirrytd qrsldrsfgl vgqsfcaalh qelreyyrll svlhsqlqle
      121 ddqgvnlgle ssltlrrllv wtydpkirlk tlaalvdhcq grkggelasa vhaytktgdp
      181 ymrslvqhil slvshpvlsf lyrwiydgel edtyheffva sdptvktdrl whdkytlrks
      241 mipsfmtmdq srkvlligks inflhqvchd qtpttkmiav tksaespqda adlftdlena
      301 fqgkidaayf etskylldvl nkkyslldhm qamrrylllg qgdfirhlmd llkpelvrpa
      361 ttlyqhnltg iletavratn aqfdspeilr rldvrllevs pgdtgwdvfs ldyhvdgpia
      421 tvftrecmsh ylrvfnflwr akrmeyiltd irkghmcnak llrnmpefsg vlhqchilas
      481 emvhfihqmq yyitfevlec swdelwnkvq qaqdldhiia ahevfldtii srclldsdsr
      541 allnqlravf dqiielqnaq daiyraalee lqrrlqfeek kkqreiegqw gvtaaeeeee
      601 nkrigefkes ipkmcsqlri lthfyqgivq qflvllttss deslrflsfr ldfnehykar
      661 eprlrvslgt rgrrssht
//
LOCUS       XP_047285995             678 aa            linear   PRI 05-AUG-2025
DEFINITION  gamma-tubulin complex component 3 isoform X5 [Homo sapiens].
ACCESSION   XP_047285995
VERSION     XP_047285995.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430039.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..678
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..678
                     /product="gamma-tubulin complex component 3 isoform X5"
                     /calculated_mol_wt=78619
     Region          22..323
                     /region_name="GCP_N_terminal"
                     /note="Gamma tubulin complex component N-terminal;
                     pfam17681"
                     /db_xref="CDD:465456"
     Region          326..657
                     /region_name="GCP_C_terminal"
                     /note="Gamma tubulin complex component C-terminal;
                     pfam04130"
                     /db_xref="CDD:461187"
     CDS             1..678
                     /gene="TUBGCP3"
                     /gene_synonym="104p; ALP6; GCP3; Grip104; SPBC98; Spc98;
                     Spc98p"
                     /coded_by="XM_047430039.1:984..3020"
                     /db_xref="GeneID:10426"
                     /db_xref="HGNC:HGNC:18598"
                     /db_xref="MIM:617818"
ORIGIN      
        1 mtrsrregdt ggtmeiteaa lvrdilyvfq gidgknikmn ntencykveg kanlsrslrd
       61 tavrlselgw lhnkirrytd qrsldrsfgl vgqsfcaalh qelreyyrll svlhsqlqle
      121 ddqgvnlgle ssltlrrllv wtydpkirlk tlaalvdhcq grkggelasa vhaytktgdp
      181 ymrslvqhil slvshpvlsf lyrwiydgel edtyheffva sdptvktdrl whdkytlrks
      241 mipsfmtmdq srkvlligks inflhqvchd qtpttkmiav tksaespqda adlftdlena
      301 fqgkidaayf etskylldvl nkkyslldhm qamrrylllg qgdfirhlmd llkpelvrpa
      361 ttlyqhnltg iletavratn aqfdspeilr rldvrllevs pgdtgwdvfs ldyhvdgpia
      421 tvftrecmsh ylrvfnflwr akrmeyiltd irkghmcnak llrnmpefsg vlhqchilas
      481 emvhfihqmq yyitfevlec swdelwnkvq qaqdldhiia ahevfldtii srclldsdsr
      541 allnqlravf dqiielqnaq daiyraalee lqrrlqfeek kkqreiegqw gvtaaeeeee
      601 nkrigefkes ipkmcsqlri lthfyqgivq qflvllttss deslrflsfr ldfnehykar
      661 eprlrvslgt rgrrssht
//
LOCUS       XP_047285997             665 aa            linear   PRI 05-AUG-2025
DEFINITION  NEDD4-binding protein 2-like 2 isoform X1 [Homo sapiens].
ACCESSION   XP_047285997
VERSION     XP_047285997.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430041.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 3% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..665
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..665
                     /product="NEDD4-binding protein 2-like 2 isoform X1"
                     /calculated_mol_wt=76755
     CDS             1..665
                     /gene="N4BP2L2"
                     /gene_synonym="92M18.3; CG005; CG016; PFAAP5"
                     /coded_by="XM_047430041.1:169..2166"
                     /db_xref="GeneID:10443"
                     /db_xref="HGNC:HGNC:26916"
                     /db_xref="MIM:615788"
ORIGIN      
        1 mfpsktatqd gshlskdrgv cfqndilvcr mnfitdiapw tatrtftgir ervlkktghr
       61 lsktkqkrnr krnkkqnsqn rimeenslef lsdltpgdqd psqseeedie ktrreseypf
      121 idglqnevgd fvtgykekrw knkdpkdsfq nvmsiveldn tpknylskeg dnlfvslllr
      181 pneisvtcpi ltqnlscvtt ddcsgmkvek hirnrhtial dtqdlsaets clfmkkreiv
      241 dknlshepil chqhgirmsd kvlreeqvyt tkinhwafft tnlsdedlql gsdrqpyfgs
      301 wpagphkfic eqrpkkdrac klagpdsrgq wiqmiftsva asepgnnpei ltdklligne
      361 dfspppetmd sfietnlfrs clpqpdipkn alestknkkr rkkrifnlvp nfdllgqsri
      421 gvkerekcdl ltknhglkit lgeekdrise rnseeenkqk lmtfdhhplw fyldiikatp
      481 lnidgqrysh clsfnrlrcs aslyknyips fvlhnlssiw kpsftnkklf ltfesqtrvg
      541 nklndagfis peilhshpdt scslgvtsdf hflnerfdrk lkrweepkel paedsqdlts
      601 tdyrslelpl sqgfafqlvk lfgspgvpme sllpddyvvp ldwktlkmiy lqwkmsvekr
      661 qkkig
//
LOCUS       XP_047285998             600 aa            linear   PRI 05-AUG-2025
DEFINITION  NEDD4-binding protein 2-like 2 isoform X2 [Homo sapiens].
ACCESSION   XP_047285998
VERSION     XP_047285998.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430042.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..600
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..600
                     /product="NEDD4-binding protein 2-like 2 isoform X2"
                     /calculated_mol_wt=68990
     Region          404..536
                     /region_name="AAA_33"
                     /note="AAA domain; pfam13671"
                     /db_xref="CDD:463952"
     CDS             1..600
                     /gene="N4BP2L2"
                     /gene_synonym="92M18.3; CG005; CG016; PFAAP5"
                     /coded_by="XM_047430042.1:114..1916"
                     /db_xref="GeneID:10443"
                     /db_xref="HGNC:HGNC:26916"
                     /db_xref="MIM:615788"
ORIGIN      
        1 msygeiegkf lgpreevtse prckklkstt esyvfhnhsn adfhriqekt gndwvpvtii
       61 dvrghsylqe nkikttdlhr plhdempgnr pdviesidsq vlqearpplv saddeiysts
      121 kafigpiykp pekkkrnegr neahvlngin drggqkekqk fnsekseidn elfqfykeie
      181 elekekdgfe nsckesepsq eqfvpfyegh nngllkpdee kkdlsnkamp shcdyqqnlg
      241 nepdkypcng qviptfcdts ftsfrpewqs vypfivpygp plpslnyhln iqrfsgppnp
      301 psnifqaqdd sqiqngyyvn nchvnwncmt fdqnneytdc senrssvhps gngcsmqdry
      361 vsngfcevre rcwkdhcmdk hngtdrfvnq qfqeeklnkl qkllillrgl pgsgkttlsr
      421 illgqnrdgi vfstddyfhh qdgyrynvnq lgdahdwnqn rakqaidqgr spviidntni
      481 qawemkpyve vaigkgyrve fhepetwwkf dpeelekrnk hgvsrkkiaq mldryeyqms
      541 isivmnsvep shkstqrppp pqgrqrrsla llprlessga ilahcklclp gsrhspasas
//
LOCUS       XP_047285999             570 aa            linear   PRI 05-AUG-2025
DEFINITION  NEDD4-binding protein 2-like 2 isoform X3 [Homo sapiens].
ACCESSION   XP_047285999
VERSION     XP_047285999.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430043.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..570
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..570
                     /product="NEDD4-binding protein 2-like 2 isoform X3"
                     /calculated_mol_wt=65989
     Region          404..536
                     /region_name="AAA_33"
                     /note="AAA domain; pfam13671"
                     /db_xref="CDD:463952"
     CDS             1..570
                     /gene="N4BP2L2"
                     /gene_synonym="92M18.3; CG005; CG016; PFAAP5"
                     /coded_by="XM_047430043.1:114..1826"
                     /db_xref="GeneID:10443"
                     /db_xref="HGNC:HGNC:26916"
                     /db_xref="MIM:615788"
ORIGIN      
        1 msygeiegkf lgpreevtse prckklkstt esyvfhnhsn adfhriqekt gndwvpvtii
       61 dvrghsylqe nkikttdlhr plhdempgnr pdviesidsq vlqearpplv saddeiysts
      121 kafigpiykp pekkkrnegr neahvlngin drggqkekqk fnsekseidn elfqfykeie
      181 elekekdgfe nsckesepsq eqfvpfyegh nngllkpdee kkdlsnkamp shcdyqqnlg
      241 nepdkypcng qviptfcdts ftsfrpewqs vypfivpygp plpslnyhln iqrfsgppnp
      301 psnifqaqdd sqiqngyyvn nchvnwncmt fdqnneytdc senrssvhps gngcsmqdry
      361 vsngfcevre rcwkdhcmdk hngtdrfvnq qfqeeklnkl qkllillrgl pgsgkttlsr
      421 illgqnrdgi vfstddyfhh qdgyrynvnq lgdahdwnqn rakqaidqgr spviidntni
      481 qawemkpyve vaigkgyrve fhepetwwkf dpeelekrnk hgvsrkkiaq mldryeyqms
      541 isivmnsvep shkstqrppp pqgrqrmvhi
//
LOCUS       XP_047286000             484 aa            linear   PRI 05-AUG-2025
DEFINITION  NEDD4-binding protein 2-like 2 isoform X4 [Homo sapiens].
ACCESSION   XP_047286000
VERSION     XP_047286000.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430044.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..484
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..484
                     /product="NEDD4-binding protein 2-like 2 isoform X4"
                     /calculated_mol_wt=55820
     Region          404..>473
                     /region_name="AAA_33"
                     /note="AAA domain; pfam13671"
                     /db_xref="CDD:463952"
     CDS             1..484
                     /gene="N4BP2L2"
                     /gene_synonym="92M18.3; CG005; CG016; PFAAP5"
                     /coded_by="XM_047430044.1:114..1568"
                     /db_xref="GeneID:10443"
                     /db_xref="HGNC:HGNC:26916"
                     /db_xref="MIM:615788"
ORIGIN      
        1 msygeiegkf lgpreevtse prckklkstt esyvfhnhsn adfhriqekt gndwvpvtii
       61 dvrghsylqe nkikttdlhr plhdempgnr pdviesidsq vlqearpplv saddeiysts
      121 kafigpiykp pekkkrnegr neahvlngin drggqkekqk fnsekseidn elfqfykeie
      181 elekekdgfe nsckesepsq eqfvpfyegh nngllkpdee kkdlsnkamp shcdyqqnlg
      241 nepdkypcng qviptfcdts ftsfrpewqs vypfivpygp plpslnyhln iqrfsgppnp
      301 psnifqaqdd sqiqngyyvn nchvnwncmt fdqnneytdc senrssvhps gngcsmqdry
      361 vsngfcevre rcwkdhcmdk hngtdrfvnq qfqeeklnkl qkllillrgl pgsgkttlsr
      421 illgqnrdgi vfstddyfhh qdgyrynvnq lgdahdwnqn rvqkmafgwe iivqkssilq
      481 qlti
//
LOCUS       XP_011533178             281 aa            linear   PRI 05-AUG-2025
DEFINITION  homeobox protein CDX-2 isoform X2 [Homo sapiens].
ACCESSION   XP_011533178
VERSION     XP_011533178.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534876.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..281
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..281
                     /product="homeobox protein CDX-2 isoform X2"
                     /calculated_mol_wt=30018
     Region          13..179
                     /region_name="Caudal_act"
                     /note="Caudal like protein activation region; pfam04731"
                     /db_xref="CDD:461413"
     Region          196..>236
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     CDS             1..281
                     /gene="CDX2"
                     /gene_synonym="CDX-3; CDX2/AS; CDX3"
                     /coded_by="XM_011534876.3:310..1155"
                     /db_xref="GeneID:1045"
                     /db_xref="HGNC:HGNC:1806"
                     /db_xref="MIM:600297"
ORIGIN      
        1 myvsylldkd vsmypssvrh sgglnlapqn fvsppqypdy ggyhvaaaaa aaanldsaqs
       61 pgpswpaayg aplredwngy apggaaaaan avahglnggs paaamgyssp adyhphhhph
      121 hhphhpaaap scasgllqtl npgppgpaat aaaeqlspgg qrrnlcewmr kpaqqslgsq
      181 altspsstvk trtkdkyrvv ytdhqrlele kefhysryit irrkaelaat lglserlksg
      241 frtaeqrrgk strrscssns ssshhsrlrr hhslpslsqv l
//
LOCUS       XP_011533180             204 aa            linear   PRI 05-AUG-2025
DEFINITION  homeobox protein CDX-2 isoform X3 [Homo sapiens].
ACCESSION   XP_011533180
VERSION     XP_011533180.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534878.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..204
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..204
                     /product="homeobox protein CDX-2 isoform X3"
                     /calculated_mol_wt=22536
     Region          79..134
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     CDS             1..204
                     /gene="CDX2"
                     /gene_synonym="CDX-3; CDX2/AS; CDX3"
                     /coded_by="XM_011534878.3:848..1462"
                     /db_xref="GeneID:1045"
                     /db_xref="HGNC:HGNC:1806"
                     /db_xref="MIM:600297"
ORIGIN      
        1 mpqlgrhagy ghfaevysql qlykskrplg avsghrflrh caharespgg naadrgeghr
       61 sasaltspss tvktrtkdky rvvytdhqrl elekefhysr yitirrkael aatlglserq
      121 vkiwfqnrra kerkinkkkl qqqqqqqppq ppppppqppq pqpgplrsvp eplspvsslq
      181 asvpgsvpgv lgptggvlnp tvtq
//
LOCUS       XP_011533181             196 aa            linear   PRI 05-AUG-2025
DEFINITION  homeobox protein CDX-2 isoform X4 [Homo sapiens].
ACCESSION   XP_011533181
VERSION     XP_011533181.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534879.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..196
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..196
                     /product="homeobox protein CDX-2 isoform X4"
                     /calculated_mol_wt=21791
     Region          71..126
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     CDS             1..196
                     /gene="CDX2"
                     /gene_synonym="CDX-3; CDX2/AS; CDX3"
                     /coded_by="XM_011534879.2:834..1424"
                     /db_xref="GeneID:1045"
                     /db_xref="HGNC:HGNC:1806"
                     /db_xref="MIM:600297"
ORIGIN      
        1 mpqlgrhagy ghfaevysql qlykskrplg avsghrflrh caharespgg naadrgeghr
       61 sasvktrtkd kyrvvytdhq rlelekefhy sryitirrka elaatlglse rqvkiwfqnr
      121 rakerkinkk klqqqqqqqp pqppppppqp pqpqpgplrs vpeplspvss lqasvpgsvp
      181 gvlgptggvl nptvtq
//
LOCUS       XP_011533184             714 aa            linear   PRI 05-AUG-2025
DEFINITION  progesterone-induced-blocking factor 1 isoform X1 [Homo sapiens].
ACCESSION   XP_011533184
VERSION     XP_011533184.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534882.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..714
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..714
                     /product="progesterone-induced-blocking factor 1 isoform
                     X1"
                     /calculated_mol_wt=84844
     Region          32..>355
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          208..>567
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..714
                     /gene="PIBF1"
                     /gene_synonym="C13orf24; CEP90; JBTS33; PIBF"
                     /coded_by="XM_011534882.4:265..2409"
                     /db_xref="GeneID:10464"
                     /db_xref="HGNC:HGNC:23352"
                     /db_xref="MIM:607532"
ORIGIN      
        1 msrkiskesk kvnisssles edislettvp tddissseer egkvritrql ierkellhni
       61 qllkielsqk tmmidnlkvd yltkieelee klndalhqkq lltlrldnql afqqkdasky
      121 qelmkqemet illrqkqlee tnlqlrekag dvrrnlrdfe lteeqyiklk afpedqlsip
      181 eyvsvrfyel vnplrkeice lqvkknilae elstnknqlk qltetyeedr knysevqirc
      241 qrlaleladt kqliqqgdyr qenydkvkse rdaleqevie lrrkheilea shmiqtkers
      301 elskevvtle qtvtllqkdk eylnrqnmel svrcaheedr lerlqaqlee skkareemye
      361 kyvasrdhyk teyenklhde leqirlktnq eidqlrnasr emyerenrsg gwevqylrtg
      421 iwqepshyii iwhkarrnlr eardnavaek eravmaekda lekhdqlldr yrelqlstes
      481 kvteflhqsk lksfeservq llqeetarnl tqcqleceky qkklevltke fyslqassek
      541 ritelqaqns ehqarldiye klekeldeii mqtaeiened eaervlfsyg yganvpttak
      601 rrlkqsvhla rrvlqlekqn slilkdlehr kdqvtqlsqe elaamkqilv kmhskhsens
      661 llltktepkh vtenqksktl nvpkehedni ftpkptlftk keapewskkq kmkt
//
LOCUS       XP_047286001             688 aa            linear   PRI 05-AUG-2025
DEFINITION  progesterone-induced-blocking factor 1 isoform X2 [Homo sapiens].
ACCESSION   XP_047286001
VERSION     XP_047286001.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430045.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..688
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..688
                     /product="progesterone-induced-blocking factor 1 isoform
                     X2"
                     /calculated_mol_wt=81982
     Region          32..>355
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          208..>567
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..688
                     /gene="PIBF1"
                     /gene_synonym="C13orf24; CEP90; JBTS33; PIBF"
                     /coded_by="XM_047430045.1:265..2331"
                     /db_xref="GeneID:10464"
                     /db_xref="HGNC:HGNC:23352"
                     /db_xref="MIM:607532"
ORIGIN      
        1 msrkiskesk kvnisssles edislettvp tddissseer egkvritrql ierkellhni
       61 qllkielsqk tmmidnlkvd yltkieelee klndalhqkq lltlrldnql afqqkdasky
      121 qelmkqemet illrqkqlee tnlqlrekag dvrrnlrdfe lteeqyiklk afpedqlsip
      181 eyvsvrfyel vnplrkeice lqvkknilae elstnknqlk qltetyeedr knysevqirc
      241 qrlaleladt kqliqqgdyr qenydkvkse rdaleqevie lrrkheilea shmiqtkers
      301 elskevvtle qtvtllqkdk eylnrqnmel svrcaheedr lerlqaqlee skkareemye
      361 kyvasrdhyk teyenklhde leqirlktnq eidqlrnasr emyerenrsg gwevqylrtg
      421 iwqepshyii iwhkarrnlr eardnavaek eravmaekda lekhdqlldr yrelqlstes
      481 kvteflhqsk lksfeservq llqeetarnl tqcqleceky qkklevltke fyslqassek
      541 ritelqaqns ehqarldiye klekeldeii mqtaeiened eaervlfsyg yganvpttak
      601 rrlkqsvhla rrvlqlekqn slilkdlehr kdqvtqlsqe ldransllnq tqqpyrylie
      661 svrqrdskid sltesiaqle kdvrnwqq
//
LOCUS       XP_024305082             685 aa            linear   PRI 05-AUG-2025
DEFINITION  progesterone-induced-blocking factor 1 isoform X3 [Homo sapiens].
ACCESSION   XP_024305082
VERSION     XP_024305082.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449314.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..685
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..685
                     /product="progesterone-induced-blocking factor 1 isoform
                     X3"
                     /calculated_mol_wt=81294
     Region          32..>355
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          206..>540
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     CDS             1..685
                     /gene="PIBF1"
                     /gene_synonym="C13orf24; CEP90; JBTS33; PIBF"
                     /coded_by="XM_024449314.2:265..2322"
                     /db_xref="GeneID:10464"
                     /db_xref="HGNC:HGNC:23352"
                     /db_xref="MIM:607532"
ORIGIN      
        1 msrkiskesk kvnisssles edislettvp tddissseer egkvritrql ierkellhni
       61 qllkielsqk tmmidnlkvd yltkieelee klndalhqkq lltlrldnql afqqkdasky
      121 qelmkqemet illrqkqlee tnlqlrekag dvrrnlrdfe lteeqyiklk afpedqlsip
      181 eyvsvrfyel vnplrkeice lqvkknilae elstnknqlk qltetyeedr knysevqirc
      241 qrlaleladt kqliqqgdyr qenydkvkse rdaleqevie lrrkheilea shmiqtkers
      301 elskevvtle qtvtllqkdk eylnrqnmel svrcaheedr lerlqaqlee skkareemye
      361 kyvasrdhyk teyenklhde leqirlktnq eidqlrnasr emyerenrnl reardnavae
      421 keravmaekd alekhdqlld ryrelqlste skvteflhqs klksfeserv qllqeetarn
      481 ltqcqlecek yqkklevltk efyslqasse kritelqaqn sehqarldiy eklekeldei
      541 imqtaeiene deaervlfsy gyganvptta krrlkqsvhl arrvlqlekq nslilkdleh
      601 rkdqvtqlsq eelaamkqil vkmhskhsen sllltktepk hvtenqkskt lnvpkehedn
      661 iftpkptlft kkeapewskk qkmkt
//
LOCUS       XP_047286002             665 aa            linear   PRI 05-AUG-2025
DEFINITION  progesterone-induced-blocking factor 1 isoform X4 [Homo sapiens].
ACCESSION   XP_047286002
VERSION     XP_047286002.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430046.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..665
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..665
                     /product="progesterone-induced-blocking factor 1 isoform
                     X4"
                     /calculated_mol_wt=78919
     Region          32..>355
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          208..>567
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..665
                     /gene="PIBF1"
                     /gene_synonym="C13orf24; CEP90; JBTS33; PIBF"
                     /coded_by="XM_047430046.1:265..2262"
                     /db_xref="GeneID:10464"
                     /db_xref="HGNC:HGNC:23352"
                     /db_xref="MIM:607532"
ORIGIN      
        1 msrkiskesk kvnisssles edislettvp tddissseer egkvritrql ierkellhni
       61 qllkielsqk tmmidnlkvd yltkieelee klndalhqkq lltlrldnql afqqkdasky
      121 qelmkqemet illrqkqlee tnlqlrekag dvrrnlrdfe lteeqyiklk afpedqlsip
      181 eyvsvrfyel vnplrkeice lqvkknilae elstnknqlk qltetyeedr knysevqirc
      241 qrlaleladt kqliqqgdyr qenydkvkse rdaleqevie lrrkheilea shmiqtkers
      301 elskevvtle qtvtllqkdk eylnrqnmel svrcaheedr lerlqaqlee skkareemye
      361 kyvasrdhyk teyenklhde leqirlktnq eidqlrnasr emyerenrsg gwevqylrtg
      421 iwqepshyii iwhkarrnlr eardnavaek eravmaekda lekhdqlldr yrelqlstes
      481 kvteflhqsk lksfeservq llqeetarnl tqcqleceky qkklevltke fyslqassek
      541 ritelqaqns ehqarldiye klekeldeii mqtaeiened eaervlfsyg yganvpttak
      601 rrlkqsvhla rrvlqlekqn slilkdlehr kdqvtqlsqe vtedgvkivs sipvlnvcti
      661 qiqqt
//
LOCUS       XP_011533187             663 aa            linear   PRI 05-AUG-2025
DEFINITION  progesterone-induced-blocking factor 1 isoform X5 [Homo sapiens].
ACCESSION   XP_011533187
VERSION     XP_011533187.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534885.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..663
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..663
                     /product="progesterone-induced-blocking factor 1 isoform
                     X5"
                     /calculated_mol_wt=78884
     Region          85..>444
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          310..>600
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     CDS             1..663
                     /gene="PIBF1"
                     /gene_synonym="C13orf24; CEP90; JBTS33; PIBF"
                     /coded_by="XM_011534885.4:335..2326"
                     /db_xref="GeneID:10464"
                     /db_xref="HGNC:HGNC:23352"
                     /db_xref="MIM:607532"
ORIGIN      
        1 mkqemetill rqkqleetnl qlrekagdvr rnlrdfelte eqyiklkafp edqlsipeyv
       61 svrfyelvnp lrkeicelqv kknilaeels tnknqlkqlt etyeedrkny sevqircqrl
      121 aleladtkql iqqgdyrqen ydkvkserda leqevielrr kheileashm iqtkersels
      181 kevvtleqtv tllqkdkeyl nrqnmelsvr caheedrler lqaqleeskk areemyekyv
      241 asrdhyktey enklhdeleq irlktnqeid qlrnasremy erenrsggwe vqylrtgiwq
      301 epshyiiiwh karrnlrear dnavaekera vmaekdalek hdqlldryre lqlsteskvt
      361 eflhqsklks feservqllq eetarnltqc qlecekyqkk levltkefys lqassekrit
      421 elqaqnsehq arldiyekle keldeiimqt aeienedeae rvlfsygyga nvpttakrrl
      481 kqsvhlarrv lqlekqnsli lkdlehrkdq vtqlsqeldr ansllnqtqq pyryliesvr
      541 qrdskidslt esiaqlekdv snlnkeksal lqtknqmald leqllnhree laamkqilvk
      601 mhskhsensl lltktepkhv tenqksktln vpkehednif tpkptlftkk eapewskkqk
      661 mkt
//
LOCUS       XP_047286003             659 aa            linear   PRI 05-AUG-2025
DEFINITION  progesterone-induced-blocking factor 1 isoform X6 [Homo sapiens].
ACCESSION   XP_047286003
VERSION     XP_047286003.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430047.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..659
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..659
                     /product="progesterone-induced-blocking factor 1 isoform
                     X6"
                     /calculated_mol_wt=78432
     Region          32..>355
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          206..>540
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     CDS             1..659
                     /gene="PIBF1"
                     /gene_synonym="C13orf24; CEP90; JBTS33; PIBF"
                     /coded_by="XM_047430047.1:265..2244"
                     /db_xref="GeneID:10464"
                     /db_xref="HGNC:HGNC:23352"
                     /db_xref="MIM:607532"
ORIGIN      
        1 msrkiskesk kvnisssles edislettvp tddissseer egkvritrql ierkellhni
       61 qllkielsqk tmmidnlkvd yltkieelee klndalhqkq lltlrldnql afqqkdasky
      121 qelmkqemet illrqkqlee tnlqlrekag dvrrnlrdfe lteeqyiklk afpedqlsip
      181 eyvsvrfyel vnplrkeice lqvkknilae elstnknqlk qltetyeedr knysevqirc
      241 qrlaleladt kqliqqgdyr qenydkvkse rdaleqevie lrrkheilea shmiqtkers
      301 elskevvtle qtvtllqkdk eylnrqnmel svrcaheedr lerlqaqlee skkareemye
      361 kyvasrdhyk teyenklhde leqirlktnq eidqlrnasr emyerenrnl reardnavae
      421 keravmaekd alekhdqlld ryrelqlste skvteflhqs klksfeserv qllqeetarn
      481 ltqcqlecek yqkklevltk efyslqasse kritelqaqn sehqarldiy eklekeldei
      541 imqtaeiene deaervlfsy gyganvptta krrlkqsvhl arrvlqlekq nslilkdleh
      601 rkdqvtqlsq eldranslln qtqqpyryli esvrqrdski dsltesiaql ekdvrnwqq
//
LOCUS       XP_011533186             640 aa            linear   PRI 05-AUG-2025
DEFINITION  progesterone-induced-blocking factor 1 isoform X7 [Homo sapiens].
ACCESSION   XP_011533186
VERSION     XP_011533186.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534884.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..640
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..640
                     /product="progesterone-induced-blocking factor 1 isoform
                     X7"
                     /calculated_mol_wt=76251
     Region          32..>355
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          208..>567
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..640
                     /gene="PIBF1"
                     /gene_synonym="C13orf24; CEP90; JBTS33; PIBF"
                     /coded_by="XM_011534884.4:265..2187"
                     /db_xref="GeneID:10464"
                     /db_xref="HGNC:HGNC:23352"
                     /db_xref="MIM:607532"
ORIGIN      
        1 msrkiskesk kvnisssles edislettvp tddissseer egkvritrql ierkellhni
       61 qllkielsqk tmmidnlkvd yltkieelee klndalhqkq lltlrldnql afqqkdasky
      121 qelmkqemet illrqkqlee tnlqlrekag dvrrnlrdfe lteeqyiklk afpedqlsip
      181 eyvsvrfyel vnplrkeice lqvkknilae elstnknqlk qltetyeedr knysevqirc
      241 qrlaleladt kqliqqgdyr qenydkvkse rdaleqevie lrrkheilea shmiqtkers
      301 elskevvtle qtvtllqkdk eylnrqnmel svrcaheedr lerlqaqlee skkareemye
      361 kyvasrdhyk teyenklhde leqirlktnq eidqlrnasr emyerenrsg gwevqylrtg
      421 iwqepshyii iwhkarrnlr eardnavaek eravmaekda lekhdqlldr yrelqlstes
      481 kvteflhqsk lksfeservq llqeetarnl tqcqleceky qkklevltke fyslqassek
      541 ritelqaqns ehqarldiye klekeldeii mqtaeiened eaervlfsyg yganvpttak
      601 rrlkqsvhla rrvlqlekqn slilkdlehr kdqvtqlsqe
//
LOCUS       XP_047286004             636 aa            linear   PRI 05-AUG-2025
DEFINITION  progesterone-induced-blocking factor 1 isoform X8 [Homo sapiens].
ACCESSION   XP_047286004
VERSION     XP_047286004.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430048.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..636
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..636
                     /product="progesterone-induced-blocking factor 1 isoform
                     X8"
                     /calculated_mol_wt=75368
     Region          32..>355
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          206..>540
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     CDS             1..636
                     /gene="PIBF1"
                     /gene_synonym="C13orf24; CEP90; JBTS33; PIBF"
                     /coded_by="XM_047430048.1:265..2175"
                     /db_xref="GeneID:10464"
                     /db_xref="HGNC:HGNC:23352"
                     /db_xref="MIM:607532"
ORIGIN      
        1 msrkiskesk kvnisssles edislettvp tddissseer egkvritrql ierkellhni
       61 qllkielsqk tmmidnlkvd yltkieelee klndalhqkq lltlrldnql afqqkdasky
      121 qelmkqemet illrqkqlee tnlqlrekag dvrrnlrdfe lteeqyiklk afpedqlsip
      181 eyvsvrfyel vnplrkeice lqvkknilae elstnknqlk qltetyeedr knysevqirc
      241 qrlaleladt kqliqqgdyr qenydkvkse rdaleqevie lrrkheilea shmiqtkers
      301 elskevvtle qtvtllqkdk eylnrqnmel svrcaheedr lerlqaqlee skkareemye
      361 kyvasrdhyk teyenklhde leqirlktnq eidqlrnasr emyerenrnl reardnavae
      421 keravmaekd alekhdqlld ryrelqlste skvteflhqs klksfeserv qllqeetarn
      481 ltqcqlecek yqkklevltk efyslqasse kritelqaqn sehqarldiy eklekeldei
      541 imqtaeiene deaervlfsy gyganvptta krrlkqsvhl arrvlqlekq nslilkdleh
      601 rkdqvtqlsq evtedgvkiv ssipvlnvct iqiqqt
//
LOCUS       XP_047286005             611 aa            linear   PRI 05-AUG-2025
DEFINITION  progesterone-induced-blocking factor 1 isoform X9 [Homo sapiens].
ACCESSION   XP_047286005
VERSION     XP_047286005.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430049.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..611
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..611
                     /product="progesterone-induced-blocking factor 1 isoform
                     X9"
                     /calculated_mol_wt=72701
     Region          32..>355
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          206..>540
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     CDS             1..611
                     /gene="PIBF1"
                     /gene_synonym="C13orf24; CEP90; JBTS33; PIBF"
                     /coded_by="XM_047430049.1:265..2100"
                     /db_xref="GeneID:10464"
                     /db_xref="HGNC:HGNC:23352"
                     /db_xref="MIM:607532"
ORIGIN      
        1 msrkiskesk kvnisssles edislettvp tddissseer egkvritrql ierkellhni
       61 qllkielsqk tmmidnlkvd yltkieelee klndalhqkq lltlrldnql afqqkdasky
      121 qelmkqemet illrqkqlee tnlqlrekag dvrrnlrdfe lteeqyiklk afpedqlsip
      181 eyvsvrfyel vnplrkeice lqvkknilae elstnknqlk qltetyeedr knysevqirc
      241 qrlaleladt kqliqqgdyr qenydkvkse rdaleqevie lrrkheilea shmiqtkers
      301 elskevvtle qtvtllqkdk eylnrqnmel svrcaheedr lerlqaqlee skkareemye
      361 kyvasrdhyk teyenklhde leqirlktnq eidqlrnasr emyerenrnl reardnavae
      421 keravmaekd alekhdqlld ryrelqlste skvteflhqs klksfeserv qllqeetarn
      481 ltqcqlecek yqkklevltk efyslqasse kritelqaqn sehqarldiy eklekeldei
      541 imqtaeiene deaervlfsy gyganvptta krrlkqsvhl arrvlqlekq nslilkdleh
      601 rkdqvtqlsq e
//
LOCUS       XP_016875840             587 aa            linear   PRI 05-AUG-2025
DEFINITION  progesterone-induced-blocking factor 1 isoform X10 [Homo sapiens].
ACCESSION   XP_016875840
VERSION     XP_016875840.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020351.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..587
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..587
                     /product="progesterone-induced-blocking factor 1 isoform
                     X10"
                     /calculated_mol_wt=70166
     Region          32..>355
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          208..>586
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..587
                     /gene="PIBF1"
                     /gene_synonym="C13orf24; CEP90; JBTS33; PIBF"
                     /coded_by="XM_017020351.2:265..2028"
                     /db_xref="GeneID:10464"
                     /db_xref="HGNC:HGNC:23352"
                     /db_xref="MIM:607532"
ORIGIN      
        1 msrkiskesk kvnisssles edislettvp tddissseer egkvritrql ierkellhni
       61 qllkielsqk tmmidnlkvd yltkieelee klndalhqkq lltlrldnql afqqkdasky
      121 qelmkqemet illrqkqlee tnlqlrekag dvrrnlrdfe lteeqyiklk afpedqlsip
      181 eyvsvrfyel vnplrkeice lqvkknilae elstnknqlk qltetyeedr knysevqirc
      241 qrlaleladt kqliqqgdyr qenydkvkse rdaleqevie lrrkheilea shmiqtkers
      301 elskevvtle qtvtllqkdk eylnrqnmel svrcaheedr lerlqaqlee skkareemye
      361 kyvasrdhyk teyenklhde leqirlktnq eidqlrnasr emyerenrsg gwevqylrtg
      421 iwqepshyii iwhkarrnlr eardnavaek eravmaekda lekhdqlldr yrelqlstes
      481 kvteflhqsk lksfeservq llqeetarnl tqcqleceky qkklevltke fyslqassek
      541 ritelqaqns ehqarldiye klekeldeii mqtaekllrr nksqlhi
//
LOCUS       XP_011533188             471 aa            linear   PRI 05-AUG-2025
DEFINITION  progesterone-induced-blocking factor 1 isoform X11 [Homo sapiens].
ACCESSION   XP_011533188
VERSION     XP_011533188.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534886.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..471
                     /product="progesterone-induced-blocking factor 1 isoform
                     X11"
                     /calculated_mol_wt=56313
     Region          <125..404
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..471
                     /gene="PIBF1"
                     /gene_synonym="C13orf24; CEP90; JBTS33; PIBF"
                     /coded_by="XM_011534886.4:265..1680"
                     /db_xref="GeneID:10464"
                     /db_xref="HGNC:HGNC:23352"
                     /db_xref="MIM:607532"
ORIGIN      
        1 msrkiskesk kvnisssles edislettvp tddissseer egkvritrql ierkellhni
       61 qllkielsqk tmmidnlkvd yltkieelee klndalhqkq lltlrldnql afqqkdasky
      121 qelmkqemet illrqkqlee tnlqlrekag dvrrnlrdfe lteeqyiklk afpedqlsip
      181 eyvsvrfyel vnplrkeice lqvkknilae elstnknqlk qltetyeedr knysevqirc
      241 qrlaleladt kqliqqgdyr qenydkvkse rdaleqevie lrrkheilea shmiqtkers
      301 elskevvtle qtvtllqkdk eylnrqnmel svrcaheedr lerlqaqlee skkareemye
      361 kyvasrdhyk teyenklhde leqirlktnq eidqlrnasr emyerenrsg gwevqylrtg
      421 iwqepshyii iwhkarrnlr eardnavaek eravmaekda lekhdqlldr f
//
LOCUS       XP_047286006             442 aa            linear   PRI 05-AUG-2025
DEFINITION  progesterone-induced-blocking factor 1 isoform X12 [Homo sapiens].
ACCESSION   XP_047286006
VERSION     XP_047286006.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430050.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..442
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..442
                     /product="progesterone-induced-blocking factor 1 isoform
                     X12"
                     /calculated_mol_wt=52763
     Region          32..>355
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <218..>441
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     CDS             1..442
                     /gene="PIBF1"
                     /gene_synonym="C13orf24; CEP90; JBTS33; PIBF"
                     /coded_by="XM_047430050.1:265..1593"
                     /db_xref="GeneID:10464"
                     /db_xref="HGNC:HGNC:23352"
                     /db_xref="MIM:607532"
ORIGIN      
        1 msrkiskesk kvnisssles edislettvp tddissseer egkvritrql ierkellhni
       61 qllkielsqk tmmidnlkvd yltkieelee klndalhqkq lltlrldnql afqqkdasky
      121 qelmkqemet illrqkqlee tnlqlrekag dvrrnlrdfe lteeqyiklk afpedqlsip
      181 eyvsvrfyel vnplrkeice lqvkknilae elstnknqlk qltetyeedr knysevqirc
      241 qrlaleladt kqliqqgdyr qenydkvkse rdaleqevie lrrkheilea shmiqtkers
      301 elskevvtle qtvtllqkdk eylnrqnmel svrcaheedr lerlqaqlee skkareemye
      361 kyvasrdhyk teyenklhde leqirlktnq eidqlrnasr emyerenrnl reardnavae
      421 keravmaekd alekhdqlld rf
//
LOCUS       XP_016875844             817 aa            linear   PRI 05-AUG-2025
DEFINITION  periostin isoform X1 [Homo sapiens].
ACCESSION   XP_016875844
VERSION     XP_016875844.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020355.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..817
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..817
                     /product="periostin isoform X1"
                     /calculated_mol_wt=90944
     Region          109..230
                     /region_name="Fasciclin"
                     /note="Fasciclin domain; pfam02469"
                     /db_xref="CDD:396845"
     Region          245..367
                     /region_name="Fasciclin"
                     /note="Fasciclin domain; pfam02469"
                     /db_xref="CDD:396845"
     Region          382..494
                     /region_name="Fasciclin"
                     /note="Fasciclin domain; pfam02469"
                     /db_xref="CDD:396845"
     Region          507..630
                     /region_name="Fasciclin"
                     /note="Fasciclin domain; pfam02469"
                     /db_xref="CDD:396845"
     CDS             1..817
                     /gene="POSTN"
                     /gene_synonym="OSF-2; OSF2; PDLPOSTN; PN"
                     /coded_by="XM_017020355.2:43..2496"
                     /db_xref="GeneID:10631"
                     /db_xref="HGNC:HGNC:16953"
                     /db_xref="MIM:608777"
ORIGIN      
        1 mipflpmfsl llllivnpin annhydkila hsrirgrdqg pnvcalqqil gtkkkyfstc
       61 knwykksicg qkttvlyecc pgymrmegmk gcpavlpidh vygtlgivga tttqrysdas
      121 klreeiegkg sftyfapsne awdnldsdir rglesnvnve llnalhshmi nkrmltkdlk
      181 ngmiipsmyn nlglfinhyp ngvvtvncar iihgnqiatn gvvhvidrvl tqigtsiqdf
      241 ieaeddlssf raaaitsdil ealgrdghft lfaptneafe klprgvleri mgdkvaseal
      301 mkyhilntlq csesimggav fetlegntie igcdgdsitv ngikmvnkkd ivtnngvihl
      361 idqvlipdsa kqvielagkq qttftdlvaq lglasalrpd geytllapvn nafsddtlsm
      421 dqrllklilq nhilkvkvgl nelyngqile tiggkqlrvf vyrtavcien scmekgskqg
      481 rngaihifre iikpaekslh eklkqdkrfs tflslleaad lkelltqpgd wtlfvptnda
      541 fkgmtseeke ilirdknalq niilyhltpg vfigkgfepg vtnilkttqg skiflkevnd
      601 tllvnelksk esdimttngv ihvvdkllyp adtpvgndql leilnkliky iqikfvrgst
      661 fkeipvtvyt tkiitkvvep kikviegslq piiktegptl tkvkiegepe frlikegeti
      721 tevihgepii kkytkiidgv pveiteketr eeriitgpei kytristggg eteetlkkll
      781 qeevtkvtkf ieggdghlfe deeikrllqg aiiakyf
//
LOCUS       XP_016875845             812 aa            linear   PRI 05-AUG-2025
DEFINITION  periostin isoform X2 [Homo sapiens].
ACCESSION   XP_016875845
VERSION     XP_016875845.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020356.2
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 1% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..812
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..812
                     /product="periostin isoform X2"
                     /calculated_mol_wt=90322
     Region          109..230
                     /region_name="Fasciclin"
                     /note="Fasciclin domain; pfam02469"
                     /db_xref="CDD:396845"
     Region          245..367
                     /region_name="Fasciclin"
                     /note="Fasciclin domain; pfam02469"
                     /db_xref="CDD:396845"
     Region          382..494
                     /region_name="Fasciclin"
                     /note="Fasciclin domain; pfam02469"
                     /db_xref="CDD:396845"
     Region          507..630
                     /region_name="Fasciclin"
                     /note="Fasciclin domain; pfam02469"
                     /db_xref="CDD:396845"
     CDS             1..812
                     /gene="POSTN"
                     /gene_synonym="OSF-2; OSF2; PDLPOSTN; PN"
                     /coded_by="XM_017020356.2:43..2481"
                     /db_xref="GeneID:10631"
                     /db_xref="HGNC:HGNC:16953"
                     /db_xref="MIM:608777"
ORIGIN      
        1 mipflpmfsl llllivnpin annhydkila hsrirgrdqg pnvcalqqil gtkkkyfstc
       61 knwykksicg qkttvlyecc pgymrmegmk gcpavlpidh vygtlgivga tttqrysdas
      121 klreeiegkg sftyfapsne awdnldsdir rglesnvnve llnalhshmi nkrmltkdlk
      181 ngmiipsmyn nlglfinhyp ngvvtvncar iihgnqiatn gvvhvidrvl tqigtsiqdf
      241 ieaeddlssf raaaitsdil ealgrdghft lfaptneafe klprgvleri mgdkvaseal
      301 mkyhilntlq csesimggav fetlegntie igcdgdsitv ngikmvnkkd ivtnngvihl
      361 idqvlipdsa kqvielagkq qttftdlvaq lglasalrpd geytllapvn nafsddtlsm
      421 dqrllklilq nhilkvkvgl nelyngqile tiggkqlrvf vyrtavcien scmekgskqg
      481 rngaihifre iikpaekslh eklkqdkrfs tflslleaad lkelltqpgd wtlfvptnda
      541 fkgmtseeke ilirdknalq niilyhltpg vfigkgfepg vtnilkttqg skiflkevnd
      601 tllvnelksk esdimttngv ihvvdkllyp adtpvgndql leilnkliky iqikfvrgst
      661 fkeipvtvyt tkiitkvvep kikviegslq piiktegptl tkvkiegepe frlikegeti
      721 tevihgepii kkytkiidgv pveiteketr eeriitgpei kytristggg eteetlkkll
      781 qeevtkvtkf ieggdghlfe deeikrllqg an
//
LOCUS       XP_047286008             785 aa            linear   PRI 05-AUG-2025
DEFINITION  periostin isoform X4 [Homo sapiens].
ACCESSION   XP_047286008
VERSION     XP_047286008.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430052.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 1% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..785
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..785
                     /product="periostin isoform X4"
                     /calculated_mol_wt=87432
     Region          109..230
                     /region_name="Fasciclin"
                     /note="Fasciclin domain; pfam02469"
                     /db_xref="CDD:396845"
     Region          245..367
                     /region_name="Fasciclin"
                     /note="Fasciclin domain; pfam02469"
                     /db_xref="CDD:396845"
     Region          382..494
                     /region_name="Fasciclin"
                     /note="Fasciclin domain; pfam02469"
                     /db_xref="CDD:396845"
     Region          507..630
                     /region_name="Fasciclin"
                     /note="Fasciclin domain; pfam02469"
                     /db_xref="CDD:396845"
     CDS             1..785
                     /gene="POSTN"
                     /gene_synonym="OSF-2; OSF2; PDLPOSTN; PN"
                     /coded_by="XM_047430052.1:43..2400"
                     /db_xref="GeneID:10631"
                     /db_xref="HGNC:HGNC:16953"
                     /db_xref="MIM:608777"
ORIGIN      
        1 mipflpmfsl llllivnpin annhydkila hsrirgrdqg pnvcalqqil gtkkkyfstc
       61 knwykksicg qkttvlyecc pgymrmegmk gcpavlpidh vygtlgivga tttqrysdas
      121 klreeiegkg sftyfapsne awdnldsdir rglesnvnve llnalhshmi nkrmltkdlk
      181 ngmiipsmyn nlglfinhyp ngvvtvncar iihgnqiatn gvvhvidrvl tqigtsiqdf
      241 ieaeddlssf raaaitsdil ealgrdghft lfaptneafe klprgvleri mgdkvaseal
      301 mkyhilntlq csesimggav fetlegntie igcdgdsitv ngikmvnkkd ivtnngvihl
      361 idqvlipdsa kqvielagkq qttftdlvaq lglasalrpd geytllapvn nafsddtlsm
      421 dqrllklilq nhilkvkvgl nelyngqile tiggkqlrvf vyrtavcien scmekgskqg
      481 rngaihifre iikpaekslh eklkqdkrfs tflslleaad lkelltqpgd wtlfvptnda
      541 fkgmtseeke ilirdknalq niilyhltpg vfigkgfepg vtnilkttqg skiflkevnd
      601 tllvnelksk esdimttngv ihvvdkllyp adtpvgndql leilnkliky iqikfvrgst
      661 fkeipvtvyr ptltkvkieg epefrlikeg etitevihge piikkytkii dgvpveitek
      721 etreeriitg peikytrist gggeteetlk kllqeevtkv tkfieggdgh lfedeeikrl
      781 lqgan
//
LOCUS       XP_047286011             199 aa            linear   PRI 05-AUG-2025
DEFINITION  tumor necrosis factor ligand superfamily member 13B isoform X1
            [Homo sapiens].
ACCESSION   XP_047286011
VERSION     XP_047286011.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430055.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..199
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..199
                     /product="tumor necrosis factor ligand superfamily member
                     13B isoform X1"
                     /calculated_mol_wt=21571
     CDS             1..199
                     /gene="TNFSF13B"
                     /gene_synonym="BAFF; BLYS; CD257; DTL; TALL-1; TALL1;
                     THANK; TNFSF20; TNLG7A; ZTNF4"
                     /coded_by="XM_047430055.1:268..867"
                     /db_xref="GeneID:10673"
                     /db_xref="HGNC:HGNC:11929"
                     /db_xref="MIM:603969"
ORIGIN      
        1 mddstereqs rltsclkkre emklkecvsi lprkespsvr sskdgkllaa tlllallscc
       61 ltvvsfyqva alqgdlaslr aelqghhaek lpagagapka gleeapavta glkifeppap
      121 gegnssqnsr nkravqgpee tvtqdclqli adsetptiqk gslllphlgq gmerflrlet
      181 fcqtlqilfp lweskenly
//
LOCUS       XP_047286013             261 aa            linear   PRI 05-AUG-2025
DEFINITION  gap junction beta-6 protein isoform X1 [Homo sapiens].
ACCESSION   XP_047286013
VERSION     XP_047286013.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430057.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..261
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..261
                     /product="gap junction beta-6 protein isoform X1"
                     /calculated_mol_wt=30256
     Region          2..215
                     /region_name="Connexin"
                     /note="pfam00029"
                     /db_xref="CDD:459638"
     CDS             1..261
                     /gene="GJB6"
                     /gene_synonym="CX30; DFNA3; DFNA3B; DFNB1B; ECTD2; ED2;
                     EDH; HED; HED2"
                     /coded_by="XM_047430057.1:348..1133"
                     /db_xref="GeneID:10804"
                     /db_xref="HGNC:HGNC:4288"
                     /db_xref="MIM:604418"
ORIGIN      
        1 mdwgtlhtfi ggvnkhstsi gkvwitvifi frvmilvvaa qevwgdeqed fvcntlqpgc
       61 knvcydhffp vshirlwalq lifvstpall vamhvayyrh ettrkfrrge krndfkdied
      121 ikkqkvrieg slwwtytssi ffriifeaaf myvfyflyng yhlpwvlkcg idpcpnlvdc
      181 fisrptektv ftifmisasv icmllnvael cylllkvcfr rskraqtqkn hpnhalkesk
      241 qnemnelisd sgqnaitgfp s
//
LOCUS       XP_011533189             853 aa            linear   PRI 05-AUG-2025
DEFINITION  heat shock protein 105 kDa isoform X1 [Homo sapiens].
ACCESSION   XP_011533189
VERSION     XP_011533189.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534887.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..853
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..853
                     /product="heat shock protein 105 kDa isoform X1"
                     /calculated_mol_wt=96458
     Region          39..383
                     /region_name="ASKHA_NBD_HSP70_HSPH1"
                     /note="nucleotide-binding domain (NBD) of heat shock
                     105kDa/110kDa protein 1 (HSPH1) and similar proteins;
                     cd11739"
                     /db_xref="CDD:466845"
     CDS             1..853
                     /gene="HSPH1"
                     /gene_synonym="HSP105; HSP105A; HSP105B; NY-CO-25"
                     /coded_by="XM_011534887.4:295..2856"
                     /db_xref="GeneID:10808"
                     /db_xref="HGNC:HGNC:16969"
                     /db_xref="MIM:610703"
ORIGIN      
        1 mataavlrgp aahwvesfqk areegsgsgt wrgrwrrrsv isfgsknrti gvaaknqqit
       61 hanntvsnfk rfhgrafndp fiqkekenls ydlvplkngg vgikvmymge ehlfsveqit
      121 amlltklket aenslkkpvt dcvisvpsff tdaerrsvld aaqivglncl rlmndmtava
      181 lnygiykqdl psldekpriv vfvdmghsaf qvsacafnkg klkvlgtafd pflggknfde
      241 klvehfcaef ktkykldaks kirallrlyq eceklkklms snstdlplni ecfmndkdvs
      301 gkmnrsqfee lcaellqkie vplyslleqt hlkvedvsav eivggatrip avkeriakff
      361 gkdisttlna deavargcal qcailspafk vrefsvtdav pfpisliwnh dsedtegvhe
      421 vfsrnhaapf skvltflrrg pfeleafysd pqgvpypeak igrfvvqnvs aqkdgeksrv
      481 kvkvrvnthg iftistasmv ekvpteenem sseadmecln qrppenpdtd knvqqdnsea
      541 gtqpqvqtda qqtsqsppsp eltseenkip dadkanekkv dqppeakkpk ikvvnvelpi
      601 eanlvwqlgk dllnmyiete gkmimqdkle kerndaknav eeyvyefrdk lcgpyekfic
      661 eqdhqnflrl ltetedwlye egedqakqay vdkleelmki gtpvkvrfqe aeerpkmfee
      721 lgqrlqhyak iaadfrnkde kynhidesem kkveksvnev mewmnnvmna qakksldqdp
      781 vvraqeiktk ikelnntcep vvtqpkpkie spklertpng pnidkkeedl edknnfgaep
      841 phqndscgiv nsy
//
LOCUS       XP_005266293             816 aa            linear   PRI 05-AUG-2025
DEFINITION  heat shock protein 105 kDa isoform X2 [Homo sapiens].
ACCESSION   XP_005266293
VERSION     XP_005266293.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266236.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..816
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..816
                     /product="heat shock protein 105 kDa isoform X2"
                     /calculated_mol_wt=92580
     Region          39..383
                     /region_name="ASKHA_NBD_HSP70_HSPH1"
                     /note="nucleotide-binding domain (NBD) of heat shock
                     105kDa/110kDa protein 1 (HSPH1) and similar proteins;
                     cd11739"
                     /db_xref="CDD:466845"
     CDS             1..816
                     /gene="HSPH1"
                     /gene_synonym="HSP105; HSP105A; HSP105B; NY-CO-25"
                     /coded_by="XM_005266236.3:295..2745"
                     /db_xref="GeneID:10808"
                     /db_xref="HGNC:HGNC:16969"
                     /db_xref="MIM:610703"
ORIGIN      
        1 mataavlrgp aahwvesfqk areegsgsgt wrgrwrrrsv isfgsknrti gvaaknqqit
       61 hanntvsnfk rfhgrafndp fiqkekenls ydlvplkngg vgikvmymge ehlfsveqit
      121 amlltklket aenslkkpvt dcvisvpsff tdaerrsvld aaqivglncl rlmndmtava
      181 lnygiykqdl psldekpriv vfvdmghsaf qvsacafnkg klkvlgtafd pflggknfde
      241 klvehfcaef ktkykldaks kirallrlyq eceklkklms snstdlplni ecfmndkdvs
      301 gkmnrsqfee lcaellqkie vplyslleqt hlkvedvsav eivggatrip avkeriakff
      361 gkdisttlna deavargcal qcailspafk vrefsvtdav pfpisliwnh dsedtegvhe
      421 vfsrnhaapf skvltflrrg pfeleafysd pqgvpypeak igrfvvqnvs aqkdgeksrv
      481 kvkvrvnthg iftistasmv ekvpteenem sseadmecln qrppenpdtd anekkvdqpp
      541 eakkpkikvv nvelpieanl vwqlgkdlln myietegkmi mqdklekern daknaveeyv
      601 yefrdklcgp yekficeqdh qnflrlltet edwlyeeged qakqayvdkl eelmkigtpv
      661 kvrfqeaeer pkmfeelgqr lqhyakiaad frnkdekynh idesemkkve ksvnevmewm
      721 nnvmnaqakk sldqdpvvra qeiktkikel nntcepvvtq pkpkiespkl ertpngpnid
      781 kkeedledkn nfgaepphqn gecypnekns vnmdld
//
LOCUS       XP_016875851             809 aa            linear   PRI 05-AUG-2025
DEFINITION  heat shock protein 105 kDa isoform X3 [Homo sapiens].
ACCESSION   XP_016875851
VERSION     XP_016875851.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020362.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..809
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..809
                     /product="heat shock protein 105 kDa isoform X3"
                     /calculated_mol_wt=91709
     Region          39..383
                     /region_name="ASKHA_NBD_HSP70_HSPH1"
                     /note="nucleotide-binding domain (NBD) of heat shock
                     105kDa/110kDa protein 1 (HSPH1) and similar proteins;
                     cd11739"
                     /db_xref="CDD:466845"
     CDS             1..809
                     /gene="HSPH1"
                     /gene_synonym="HSP105; HSP105A; HSP105B; NY-CO-25"
                     /coded_by="XM_017020362.3:295..2724"
                     /db_xref="GeneID:10808"
                     /db_xref="HGNC:HGNC:16969"
                     /db_xref="MIM:610703"
ORIGIN      
        1 mataavlrgp aahwvesfqk areegsgsgt wrgrwrrrsv isfgsknrti gvaaknqqit
       61 hanntvsnfk rfhgrafndp fiqkekenls ydlvplkngg vgikvmymge ehlfsveqit
      121 amlltklket aenslkkpvt dcvisvpsff tdaerrsvld aaqivglncl rlmndmtava
      181 lnygiykqdl psldekpriv vfvdmghsaf qvsacafnkg klkvlgtafd pflggknfde
      241 klvehfcaef ktkykldaks kirallrlyq eceklkklms snstdlplni ecfmndkdvs
      301 gkmnrsqfee lcaellqkie vplyslleqt hlkvedvsav eivggatrip avkeriakff
      361 gkdisttlna deavargcal qcailspafk vrefsvtdav pfpisliwnh dsedtegvhe
      421 vfsrnhaapf skvltflrrg pfeleafysd pqgvpypeak igrfvvqnvs aqkdgeksrv
      481 kvkvrvnthg iftistasmv ekvpteenem sseadmecln qrppenpdtd anekkvdqpp
      541 eakkpkikvv nvelpieanl vwqlgkdlln myietegkmi mqdklekern daknaveeyv
      601 yefrdklcgp yekficeqdh qnflrlltet edwlyeeged qakqayvdkl eelmkigtpv
      661 kvrfqeaeer pkmfeelgqr lqhyakiaad frnkdekynh idesemkkve ksvnevmewm
      721 nnvmnaqakk sldqdpvvra qeiktkikel nntcepvvtq pkpkiespkl ertpngpnid
      781 kkeedledkn nfgaepphqn dscgivnsy
//
LOCUS       XP_016875852             807 aa            linear   PRI 05-AUG-2025
DEFINITION  heat shock protein 105 kDa isoform X4 [Homo sapiens].
ACCESSION   XP_016875852
VERSION     XP_016875852.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020363.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..807
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..807
                     /product="heat shock protein 105 kDa isoform X4"
                     /calculated_mol_wt=91114
     Region          2..381
                     /region_name="ASKHA_NBD_HSP70_HSPH1"
                     /note="nucleotide-binding domain (NBD) of heat shock
                     105kDa/110kDa protein 1 (HSPH1) and similar proteins;
                     cd11739"
                     /db_xref="CDD:466845"
     CDS             1..807
                     /gene="HSPH1"
                     /gene_synonym="HSP105; HSP105A; HSP105B; NY-CO-25"
                     /coded_by="XM_017020363.3:323..2746"
                     /db_xref="GeneID:10808"
                     /db_xref="HGNC:HGNC:16969"
                     /db_xref="MIM:610703"
ORIGIN      
        1 msvvgldvgs qscyiavara ggietianef sdrctpsvis fgsknrtigv aaknqqitha
       61 nntvsnfkrf hgrafndpfi qkekenlsyd lvplknggvg ikvmymgeeh lfsveqitam
      121 lltklketae nslkkpvtdc visvpsfftd aerrsvldaa qivglnclrl mndmtavaln
      181 ygiykqdlps ldekprivvf vdmghsafqv sacafnkgkl kvlgtafdpf lggknfdekl
      241 vehfcaefkt kykldakski rallrlyqec eklkklmssn stdlplniec fmndkdvsgk
      301 mnrsqfeelc aellqkievp lyslleqthl kvedvsavei vggatripav keriakffgk
      361 disttlnade avargcalqc ailspafkvr efsvtdavpf pisliwnhds edtegvhevf
      421 srnhaapfsk vltflrrgpf eleafysdpq gvpypeakig rfvvqnvsaq kdgeksrvkv
      481 kvrvnthgif tistasmvek vpteenemss eadmeclnqr ppenpdtdan ekkvdqppea
      541 kkpkikvvnv elpieanlvw qlgkdllnmy ietegkmimq dklekernda knaveeyvye
      601 frdklcgpye kficeqdhqn flrllteted wlyeegedqa kqayvdklee lmkigtpvkv
      661 rfqeaeerpk mfeelgqrlq hyakiaadfr nkdekynhid esemkkveks vnevmewmnn
      721 vmnaqakksl dqdpvvraqe iktkikelnn tcepvvtqpk pkiespkler tpngpnidkk
      781 eedledknnf gaepphqnds cgivnsy
//
LOCUS       XP_011533190             780 aa            linear   PRI 05-AUG-2025
DEFINITION  heat shock protein 105 kDa isoform X5 [Homo sapiens].
ACCESSION   XP_011533190
VERSION     XP_011533190.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534888.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..780
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..780
                     /product="heat shock protein 105 kDa isoform X5"
                     /calculated_mol_wt=88116
     Region          2..303
                     /region_name="ASKHA_ATPase-like"
                     /note="ATPase-like domain of the ASKHA (Acetate and Sugar
                     Kinases/Hsc70/Actin) superfamily; cl49607"
                     /db_xref="CDD:483947"
     CDS             1..780
                     /gene="HSPH1"
                     /gene_synonym="HSP105; HSP105A; HSP105B; NY-CO-25"
                     /coded_by="XM_011534888.3:323..2665"
                     /db_xref="GeneID:10808"
                     /db_xref="HGNC:HGNC:16969"
                     /db_xref="MIM:610703"
ORIGIN      
        1 msvvgldvgs qscyiavara ggietianef sdrctpsvis fgsknrtigv aaknqqitha
       61 nntvsnfkrf hgrafndpfi qkekenlsyd lvplknggvg ikvmymgeeh lfsveqitam
      121 lltklketae nslkkpvtdc visvlgtafd pflggknfde klvehfcaef ktkykldaks
      181 kirallrlyq eceklkklms snstdlplni ecfmndkdvs gkmnrsqfee lcaellqkie
      241 vplyslleqt hlkvedvsav eivggatrip avkeriakff gkdisttlna deavargcal
      301 qcailspafk vrefsvtdav pfpisliwnh dsedtegvhe vfsrnhaapf skvltflrrg
      361 pfeleafysd pqgvpypeak igrfvvqnvs aqkdgeksrv kvkvrvnthg iftistasmv
      421 ekvpteenem sseadmecln qrppenpdtd knvqqdnsea gtqpqvqtda qqtsqsppsp
      481 eltseenkip dadkanekkv dqppeakkpk ikvvnvelpi eanlvwqlgk dllnmyiete
      541 gkmimqdkle kerndaknav eeyvyefrdk lcgpyekfic eqdhqnflrl ltetedwlye
      601 egedqakqay vdkleelmki gtpvkvrfqe aeerpkmfee lgqrlqhyak iaadfrnkde
      661 kynhidesem kkveksvnev mewmnnvmna qakksldqdp vvraqeiktk ikelnntcep
      721 vvtqpkpkie spklertpng pnidkkeedl edknnfgaep phqngecypn eknsvnmdld
//
LOCUS       XP_047286014             773 aa            linear   PRI 05-AUG-2025
DEFINITION  heat shock protein 105 kDa isoform X6 [Homo sapiens].
ACCESSION   XP_047286014
VERSION     XP_047286014.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430058.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..773
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..773
                     /product="heat shock protein 105 kDa isoform X6"
                     /calculated_mol_wt=87245
     Region          2..303
                     /region_name="ASKHA_ATPase-like"
                     /note="ATPase-like domain of the ASKHA (Acetate and Sugar
                     Kinases/Hsc70/Actin) superfamily; cl49607"
                     /db_xref="CDD:483947"
     CDS             1..773
                     /gene="HSPH1"
                     /gene_synonym="HSP105; HSP105A; HSP105B; NY-CO-25"
                     /coded_by="XM_047430058.1:323..2644"
                     /db_xref="GeneID:10808"
                     /db_xref="HGNC:HGNC:16969"
                     /db_xref="MIM:610703"
ORIGIN      
        1 msvvgldvgs qscyiavara ggietianef sdrctpsvis fgsknrtigv aaknqqitha
       61 nntvsnfkrf hgrafndpfi qkekenlsyd lvplknggvg ikvmymgeeh lfsveqitam
      121 lltklketae nslkkpvtdc visvlgtafd pflggknfde klvehfcaef ktkykldaks
      181 kirallrlyq eceklkklms snstdlplni ecfmndkdvs gkmnrsqfee lcaellqkie
      241 vplyslleqt hlkvedvsav eivggatrip avkeriakff gkdisttlna deavargcal
      301 qcailspafk vrefsvtdav pfpisliwnh dsedtegvhe vfsrnhaapf skvltflrrg
      361 pfeleafysd pqgvpypeak igrfvvqnvs aqkdgeksrv kvkvrvnthg iftistasmv
      421 ekvpteenem sseadmecln qrppenpdtd knvqqdnsea gtqpqvqtda qqtsqsppsp
      481 eltseenkip dadkanekkv dqppeakkpk ikvvnvelpi eanlvwqlgk dllnmyiete
      541 gkmimqdkle kerndaknav eeyvyefrdk lcgpyekfic eqdhqnflrl ltetedwlye
      601 egedqakqay vdkleelmki gtpvkvrfqe aeerpkmfee lgqrlqhyak iaadfrnkde
      661 kynhidesem kkveksvnev mewmnnvmna qakksldqdp vvraqeiktk ikelnntcep
      721 vvtqpkpkie spklertpng pnidkkeedl edknnfgaep phqndscgiv nsy
//
LOCUS       XP_016875853             736 aa            linear   PRI 05-AUG-2025
DEFINITION  heat shock protein 105 kDa isoform X7 [Homo sapiens].
ACCESSION   XP_016875853
VERSION     XP_016875853.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020364.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..736
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..736
                     /product="heat shock protein 105 kDa isoform X7"
                     /calculated_mol_wt=83367
     Region          2..303
                     /region_name="ASKHA_ATPase-like"
                     /note="ATPase-like domain of the ASKHA (Acetate and Sugar
                     Kinases/Hsc70/Actin) superfamily; cl49607"
                     /db_xref="CDD:483947"
     CDS             1..736
                     /gene="HSPH1"
                     /gene_synonym="HSP105; HSP105A; HSP105B; NY-CO-25"
                     /coded_by="XM_017020364.3:323..2533"
                     /db_xref="GeneID:10808"
                     /db_xref="HGNC:HGNC:16969"
                     /db_xref="MIM:610703"
ORIGIN      
        1 msvvgldvgs qscyiavara ggietianef sdrctpsvis fgsknrtigv aaknqqitha
       61 nntvsnfkrf hgrafndpfi qkekenlsyd lvplknggvg ikvmymgeeh lfsveqitam
      121 lltklketae nslkkpvtdc visvlgtafd pflggknfde klvehfcaef ktkykldaks
      181 kirallrlyq eceklkklms snstdlplni ecfmndkdvs gkmnrsqfee lcaellqkie
      241 vplyslleqt hlkvedvsav eivggatrip avkeriakff gkdisttlna deavargcal
      301 qcailspafk vrefsvtdav pfpisliwnh dsedtegvhe vfsrnhaapf skvltflrrg
      361 pfeleafysd pqgvpypeak igrfvvqnvs aqkdgeksrv kvkvrvnthg iftistasmv
      421 ekvpteenem sseadmecln qrppenpdtd anekkvdqpp eakkpkikvv nvelpieanl
      481 vwqlgkdlln myietegkmi mqdklekern daknaveeyv yefrdklcgp yekficeqdh
      541 qnflrlltet edwlyeeged qakqayvdkl eelmkigtpv kvrfqeaeer pkmfeelgqr
      601 lqhyakiaad frnkdekynh idesemkkve ksvnevmewm nnvmnaqakk sldqdpvvra
      661 qeiktkikel nntcepvvtq pkpkiespkl ertpngpnid kkeedledkn nfgaepphqn
      721 gecypnekns vnmdld
//
LOCUS       XP_011533191             502 aa            linear   PRI 05-AUG-2025
DEFINITION  actin-binding protein WASF3 isoform X1 [Homo sapiens].
ACCESSION   XP_011533191
VERSION     XP_011533191.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534889.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..502
                     /product="actin-binding protein WASF3 isoform X1"
                     /calculated_mol_wt=55162
     Region          437..502
                     /region_name="WH2_WAVE-3"
                     /note="Wiskott Aldrich syndrome homology region 2 (WH2
                     motif) found in Wiskott-Aldrich Syndrome Protein Family
                     Member 3 (WASP-3 or WAVE3); cd22073"
                     /db_xref="CDD:409216"
     Site            order(440..441,443..445,447..449,454..457)
                     /site_type="other"
                     /note="actin-binding motif [polypeptide binding]"
                     /db_xref="CDD:409216"
     Region          454..457
                     /region_name="actin-binding sequence"
                     /note="actin-binding sequence [structural motif]"
                     /db_xref="CDD:409216"
     CDS             1..502
                     /gene="WASF3"
                     /gene_synonym="Brush-1; SCAR3; WAVE3"
                     /coded_by="XM_011534889.3:267..1775"
                     /db_xref="GeneID:10810"
                     /db_xref="HGNC:HGNC:12734"
                     /db_xref="MIM:605068"
ORIGIN      
        1 mplvkrniep rhlcrgalpe gitselecvt nstlaaiirq lsslskhaed ifgelfnean
       61 nfyiranslq dridrlavkv tqldstveev slqdinmkka fksstvqdqq vvsknsipnp
      121 vadiynqsdk ppplniltpy rddkkdglkf ytdpsyffdl wkekmlqdte dkrkekrrqk
      181 eqkridgttr evkkvrkarn rrqewnmmay dkelrpdnrl sqsvyhgass egslspdtrs
      241 hasdvtdysy patpnhslhp qpvtpsyaag dvpphgpasq aaeheyrpps asarhmalnr
      301 pqqppppppp qapegsqasa pmapadygml paqiieyynp sgpppppppp vipsaqtafv
      361 splqmpmqpp fpasasstha apphppstgl lvtappppgp pppppgppgp gsslssspmh
      421 gppvaeakrq epaqppisda rsdllaairm giqlkkvqeq reqeakrepv gndvatilsr
      481 riaveysdsd ddsefdendw sd
//
LOCUS       XP_047286015             502 aa            linear   PRI 05-AUG-2025
DEFINITION  actin-binding protein WASF3 isoform X1 [Homo sapiens].
ACCESSION   XP_047286015
VERSION     XP_047286015.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430059.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..502
                     /product="actin-binding protein WASF3 isoform X1"
                     /calculated_mol_wt=55162
     Region          437..502
                     /region_name="WH2_WAVE-3"
                     /note="Wiskott Aldrich syndrome homology region 2 (WH2
                     motif) found in Wiskott-Aldrich Syndrome Protein Family
                     Member 3 (WASP-3 or WAVE3); cd22073"
                     /db_xref="CDD:409216"
     Site            order(440..441,443..445,447..449,454..457)
                     /site_type="other"
                     /note="actin-binding motif [polypeptide binding]"
                     /db_xref="CDD:409216"
     Region          454..457
                     /region_name="actin-binding sequence"
                     /note="actin-binding sequence [structural motif]"
                     /db_xref="CDD:409216"
     CDS             1..502
                     /gene="WASF3"
                     /gene_synonym="Brush-1; SCAR3; WAVE3"
                     /coded_by="XM_047430059.1:219..1727"
                     /db_xref="GeneID:10810"
                     /db_xref="HGNC:HGNC:12734"
                     /db_xref="MIM:605068"
ORIGIN      
        1 mplvkrniep rhlcrgalpe gitselecvt nstlaaiirq lsslskhaed ifgelfnean
       61 nfyiranslq dridrlavkv tqldstveev slqdinmkka fksstvqdqq vvsknsipnp
      121 vadiynqsdk ppplniltpy rddkkdglkf ytdpsyffdl wkekmlqdte dkrkekrrqk
      181 eqkridgttr evkkvrkarn rrqewnmmay dkelrpdnrl sqsvyhgass egslspdtrs
      241 hasdvtdysy patpnhslhp qpvtpsyaag dvpphgpasq aaeheyrpps asarhmalnr
      301 pqqppppppp qapegsqasa pmapadygml paqiieyynp sgpppppppp vipsaqtafv
      361 splqmpmqpp fpasasstha apphppstgl lvtappppgp pppppgppgp gsslssspmh
      421 gppvaeakrq epaqppisda rsdllaairm giqlkkvqeq reqeakrepv gndvatilsr
      481 riaveysdsd ddsefdendw sd
//
LOCUS       XP_047286016             502 aa            linear   PRI 05-AUG-2025
DEFINITION  actin-binding protein WASF3 isoform X1 [Homo sapiens].
ACCESSION   XP_047286016
VERSION     XP_047286016.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430060.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..502
                     /product="actin-binding protein WASF3 isoform X1"
                     /calculated_mol_wt=55162
     Region          437..502
                     /region_name="WH2_WAVE-3"
                     /note="Wiskott Aldrich syndrome homology region 2 (WH2
                     motif) found in Wiskott-Aldrich Syndrome Protein Family
                     Member 3 (WASP-3 or WAVE3); cd22073"
                     /db_xref="CDD:409216"
     Site            order(440..441,443..445,447..449,454..457)
                     /site_type="other"
                     /note="actin-binding motif [polypeptide binding]"
                     /db_xref="CDD:409216"
     Region          454..457
                     /region_name="actin-binding sequence"
                     /note="actin-binding sequence [structural motif]"
                     /db_xref="CDD:409216"
     CDS             1..502
                     /gene="WASF3"
                     /gene_synonym="Brush-1; SCAR3; WAVE3"
                     /coded_by="XM_047430060.1:592..2100"
                     /db_xref="GeneID:10810"
                     /db_xref="HGNC:HGNC:12734"
                     /db_xref="MIM:605068"
ORIGIN      
        1 mplvkrniep rhlcrgalpe gitselecvt nstlaaiirq lsslskhaed ifgelfnean
       61 nfyiranslq dridrlavkv tqldstveev slqdinmkka fksstvqdqq vvsknsipnp
      121 vadiynqsdk ppplniltpy rddkkdglkf ytdpsyffdl wkekmlqdte dkrkekrrqk
      181 eqkridgttr evkkvrkarn rrqewnmmay dkelrpdnrl sqsvyhgass egslspdtrs
      241 hasdvtdysy patpnhslhp qpvtpsyaag dvpphgpasq aaeheyrpps asarhmalnr
      301 pqqppppppp qapegsqasa pmapadygml paqiieyynp sgpppppppp vipsaqtafv
      361 splqmpmqpp fpasasstha apphppstgl lvtappppgp pppppgppgp gsslssspmh
      421 gppvaeakrq epaqppisda rsdllaairm giqlkkvqeq reqeakrepv gndvatilsr
      481 riaveysdsd ddsefdendw sd
//
LOCUS       XP_011533192             502 aa            linear   PRI 05-AUG-2025
DEFINITION  actin-binding protein WASF3 isoform X1 [Homo sapiens].
ACCESSION   XP_011533192
VERSION     XP_011533192.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534890.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..502
                     /product="actin-binding protein WASF3 isoform X1"
                     /calculated_mol_wt=55162
     Region          437..502
                     /region_name="WH2_WAVE-3"
                     /note="Wiskott Aldrich syndrome homology region 2 (WH2
                     motif) found in Wiskott-Aldrich Syndrome Protein Family
                     Member 3 (WASP-3 or WAVE3); cd22073"
                     /db_xref="CDD:409216"
     Site            order(440..441,443..445,447..449,454..457)
                     /site_type="other"
                     /note="actin-binding motif [polypeptide binding]"
                     /db_xref="CDD:409216"
     Region          454..457
                     /region_name="actin-binding sequence"
                     /note="actin-binding sequence [structural motif]"
                     /db_xref="CDD:409216"
     CDS             1..502
                     /gene="WASF3"
                     /gene_synonym="Brush-1; SCAR3; WAVE3"
                     /coded_by="XM_011534890.2:182..1690"
                     /db_xref="GeneID:10810"
                     /db_xref="HGNC:HGNC:12734"
                     /db_xref="MIM:605068"
ORIGIN      
        1 mplvkrniep rhlcrgalpe gitselecvt nstlaaiirq lsslskhaed ifgelfnean
       61 nfyiranslq dridrlavkv tqldstveev slqdinmkka fksstvqdqq vvsknsipnp
      121 vadiynqsdk ppplniltpy rddkkdglkf ytdpsyffdl wkekmlqdte dkrkekrrqk
      181 eqkridgttr evkkvrkarn rrqewnmmay dkelrpdnrl sqsvyhgass egslspdtrs
      241 hasdvtdysy patpnhslhp qpvtpsyaag dvpphgpasq aaeheyrpps asarhmalnr
      301 pqqppppppp qapegsqasa pmapadygml paqiieyynp sgpppppppp vipsaqtafv
      361 splqmpmqpp fpasasstha apphppstgl lvtappppgp pppppgppgp gsslssspmh
      421 gppvaeakrq epaqppisda rsdllaairm giqlkkvqeq reqeakrepv gndvatilsr
      481 riaveysdsd ddsefdendw sd
//
LOCUS       XP_024305083             502 aa            linear   PRI 05-AUG-2025
DEFINITION  actin-binding protein WASF3 isoform X1 [Homo sapiens].
ACCESSION   XP_024305083
VERSION     XP_024305083.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449315.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..502
                     /product="actin-binding protein WASF3 isoform X1"
                     /calculated_mol_wt=55162
     Region          437..502
                     /region_name="WH2_WAVE-3"
                     /note="Wiskott Aldrich syndrome homology region 2 (WH2
                     motif) found in Wiskott-Aldrich Syndrome Protein Family
                     Member 3 (WASP-3 or WAVE3); cd22073"
                     /db_xref="CDD:409216"
     Site            order(440..441,443..445,447..449,454..457)
                     /site_type="other"
                     /note="actin-binding motif [polypeptide binding]"
                     /db_xref="CDD:409216"
     Region          454..457
                     /region_name="actin-binding sequence"
                     /note="actin-binding sequence [structural motif]"
                     /db_xref="CDD:409216"
     CDS             1..502
                     /gene="WASF3"
                     /gene_synonym="Brush-1; SCAR3; WAVE3"
                     /coded_by="XM_024449315.2:208..1716"
                     /db_xref="GeneID:10810"
                     /db_xref="HGNC:HGNC:12734"
                     /db_xref="MIM:605068"
ORIGIN      
        1 mplvkrniep rhlcrgalpe gitselecvt nstlaaiirq lsslskhaed ifgelfnean
       61 nfyiranslq dridrlavkv tqldstveev slqdinmkka fksstvqdqq vvsknsipnp
      121 vadiynqsdk ppplniltpy rddkkdglkf ytdpsyffdl wkekmlqdte dkrkekrrqk
      181 eqkridgttr evkkvrkarn rrqewnmmay dkelrpdnrl sqsvyhgass egslspdtrs
      241 hasdvtdysy patpnhslhp qpvtpsyaag dvpphgpasq aaeheyrpps asarhmalnr
      301 pqqppppppp qapegsqasa pmapadygml paqiieyynp sgpppppppp vipsaqtafv
      361 splqmpmqpp fpasasstha apphppstgl lvtappppgp pppppgppgp gsslssspmh
      421 gppvaeakrq epaqppisda rsdllaairm giqlkkvqeq reqeakrepv gndvatilsr
      481 riaveysdsd ddsefdendw sd
//
LOCUS       XP_047286018             499 aa            linear   PRI 05-AUG-2025
DEFINITION  actin-binding protein WASF3 isoform X2 [Homo sapiens].
ACCESSION   XP_047286018
VERSION     XP_047286018.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430062.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..499
                     /product="actin-binding protein WASF3 isoform X2"
                     /calculated_mol_wt=54876
     Region          434..499
                     /region_name="WH2_WAVE-3"
                     /note="Wiskott Aldrich syndrome homology region 2 (WH2
                     motif) found in Wiskott-Aldrich Syndrome Protein Family
                     Member 3 (WASP-3 or WAVE3); cd22073"
                     /db_xref="CDD:409216"
     Site            order(437..438,440..442,444..446,451..454)
                     /site_type="other"
                     /note="actin-binding motif [polypeptide binding]"
                     /db_xref="CDD:409216"
     Region          451..454
                     /region_name="actin-binding sequence"
                     /note="actin-binding sequence [structural motif]"
                     /db_xref="CDD:409216"
     CDS             1..499
                     /gene="WASF3"
                     /gene_synonym="Brush-1; SCAR3; WAVE3"
                     /coded_by="XM_047430062.1:266..1765"
                     /db_xref="GeneID:10810"
                     /db_xref="HGNC:HGNC:12734"
                     /db_xref="MIM:605068"
ORIGIN      
        1 mplvkrniep rhlcrgalpe gitselecvt nstlaaiirq lsslskhaed ifgelfnean
       61 nfyiranslq dridrlavkv tqldstveev slqdinmkka fksstvqdqq vvsknsipnp
      121 vadiynqsdk ppplniltpy rddkkdglkf ytdpsyffdl wkekmlqdte dkrkekrrqk
      181 rekhklnpnr nqqvnvrkvr trkeewerrk mgiefmsdak kleqagsake drvpsgshas
      241 dvtdysypat pnhslhpqpv tpsyaagdvp phgpasqaae heyrppsasa rhmalnrpqq
      301 pppppppqap egsqasapma padygmlpaq iieyynpsgp pppppppvip saqtafvspl
      361 qmpmqppfpa sassthaapp hppstgllvt appppgpppp ppgppgpgss lssspmhgpp
      421 vaeakrqepa qppisdarsd llaairmgiq lkkvqeqreq eakrepvgnd vatilsrria
      481 veysdsddds efdendwsd
//
LOCUS       XP_047286019             499 aa            linear   PRI 05-AUG-2025
DEFINITION  actin-binding protein WASF3 isoform X2 [Homo sapiens].
ACCESSION   XP_047286019
VERSION     XP_047286019.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430063.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..499
                     /product="actin-binding protein WASF3 isoform X2"
                     /calculated_mol_wt=54876
     Region          434..499
                     /region_name="WH2_WAVE-3"
                     /note="Wiskott Aldrich syndrome homology region 2 (WH2
                     motif) found in Wiskott-Aldrich Syndrome Protein Family
                     Member 3 (WASP-3 or WAVE3); cd22073"
                     /db_xref="CDD:409216"
     Site            order(437..438,440..442,444..446,451..454)
                     /site_type="other"
                     /note="actin-binding motif [polypeptide binding]"
                     /db_xref="CDD:409216"
     Region          451..454
                     /region_name="actin-binding sequence"
                     /note="actin-binding sequence [structural motif]"
                     /db_xref="CDD:409216"
     CDS             1..499
                     /gene="WASF3"
                     /gene_synonym="Brush-1; SCAR3; WAVE3"
                     /coded_by="XM_047430063.1:219..1718"
                     /db_xref="GeneID:10810"
                     /db_xref="HGNC:HGNC:12734"
                     /db_xref="MIM:605068"
ORIGIN      
        1 mplvkrniep rhlcrgalpe gitselecvt nstlaaiirq lsslskhaed ifgelfnean
       61 nfyiranslq dridrlavkv tqldstveev slqdinmkka fksstvqdqq vvsknsipnp
      121 vadiynqsdk ppplniltpy rddkkdglkf ytdpsyffdl wkekmlqdte dkrkekrrqk
      181 rekhklnpnr nqqvnvrkvr trkeewerrk mgiefmsdak kleqagsake drvpsgshas
      241 dvtdysypat pnhslhpqpv tpsyaagdvp phgpasqaae heyrppsasa rhmalnrpqq
      301 pppppppqap egsqasapma padygmlpaq iieyynpsgp pppppppvip saqtafvspl
      361 qmpmqppfpa sassthaapp hppstgllvt appppgpppp ppgppgpgss lssspmhgpp
      421 vaeakrqepa qppisdarsd llaairmgiq lkkvqeqreq eakrepvgnd vatilsrria
      481 veysdsddds efdendwsd
//
LOCUS       XP_047286020             499 aa            linear   PRI 05-AUG-2025
DEFINITION  actin-binding protein WASF3 isoform X2 [Homo sapiens].
ACCESSION   XP_047286020
VERSION     XP_047286020.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430064.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..499
                     /product="actin-binding protein WASF3 isoform X2"
                     /calculated_mol_wt=54876
     Region          434..499
                     /region_name="WH2_WAVE-3"
                     /note="Wiskott Aldrich syndrome homology region 2 (WH2
                     motif) found in Wiskott-Aldrich Syndrome Protein Family
                     Member 3 (WASP-3 or WAVE3); cd22073"
                     /db_xref="CDD:409216"
     Site            order(437..438,440..442,444..446,451..454)
                     /site_type="other"
                     /note="actin-binding motif [polypeptide binding]"
                     /db_xref="CDD:409216"
     Region          451..454
                     /region_name="actin-binding sequence"
                     /note="actin-binding sequence [structural motif]"
                     /db_xref="CDD:409216"
     CDS             1..499
                     /gene="WASF3"
                     /gene_synonym="Brush-1; SCAR3; WAVE3"
                     /coded_by="XM_047430064.1:592..2091"
                     /db_xref="GeneID:10810"
                     /db_xref="HGNC:HGNC:12734"
                     /db_xref="MIM:605068"
ORIGIN      
        1 mplvkrniep rhlcrgalpe gitselecvt nstlaaiirq lsslskhaed ifgelfnean
       61 nfyiranslq dridrlavkv tqldstveev slqdinmkka fksstvqdqq vvsknsipnp
      121 vadiynqsdk ppplniltpy rddkkdglkf ytdpsyffdl wkekmlqdte dkrkekrrqk
      181 rekhklnpnr nqqvnvrkvr trkeewerrk mgiefmsdak kleqagsake drvpsgshas
      241 dvtdysypat pnhslhpqpv tpsyaagdvp phgpasqaae heyrppsasa rhmalnrpqq
      301 pppppppqap egsqasapma padygmlpaq iieyynpsgp pppppppvip saqtafvspl
      361 qmpmqppfpa sassthaapp hppstgllvt appppgpppp ppgppgpgss lssspmhgpp
      421 vaeakrqepa qppisdarsd llaairmgiq lkkvqeqreq eakrepvgnd vatilsrria
      481 veysdsddds efdendwsd
//
LOCUS       XP_016875854             364 aa            linear   PRI 05-AUG-2025
DEFINITION  protein SGT1 homolog isoform X1 [Homo sapiens].
ACCESSION   XP_016875854
VERSION     XP_016875854.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020365.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..364
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..364
                     /product="protein SGT1 homolog isoform X1"
                     /calculated_mol_wt=40779
     Region          21..364
                     /region_name="PLN03088"
                     /note="SGT1, suppressor of G2 allele of SKP1; Provisional"
                     /db_xref="CDD:215568"
     Region          44..74
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          79..107
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..364
                     /gene="SUGT1"
                     /gene_synonym="SGT1"
                     /coded_by="XM_017020365.2:86..1180"
                     /db_xref="GeneID:10910"
                     /db_xref="HGNC:HGNC:16987"
                     /db_xref="MIM:604098"
ORIGIN      
        1 maaaaagtat sqrffqsfsd alidedpqaa leeltkaleq kpddaqyycq raychillgn
       61 ycvavadakk slelnpnnst amlrkgicey heknyaaale tftegqkldk tgfhrvgqag
      121 lqlltssdpp aldsqsagit gadanfsvwi krcqeaqngs esevwthqsk ikydwyqtes
      181 qvvitlmikn vqkndvnvef sekelsalvk lpsgedynlk lellhpiipe qstfkvlstk
      241 ieiklkkpea vrweklegqg dvptpkqfva dvknlypsss pytrnwdklv geikeeekne
      301 klegdaalnr lfqqiysdgs devkramnks fmesggtvls tnwsdvgkrk veinppddme
      361 wkky
//
LOCUS       XP_047286021             284 aa            linear   PRI 05-AUG-2025
DEFINITION  protein SGT1 homolog isoform X2 [Homo sapiens].
ACCESSION   XP_047286021
VERSION     XP_047286021.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430065.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..284
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..284
                     /product="protein SGT1 homolog isoform X2"
                     /calculated_mol_wt=32122
     Region          <57..284
                     /region_name="PLN03088"
                     /note="SGT1, suppressor of G2 allele of SKP1; Provisional"
                     /db_xref="CDD:215568"
     CDS             1..284
                     /gene="SUGT1"
                     /gene_synonym="SGT1"
                     /coded_by="XM_047430065.1:234..1088"
                     /db_xref="GeneID:10910"
                     /db_xref="HGNC:HGNC:16987"
                     /db_xref="MIM:604098"
ORIGIN      
        1 mlrkgiceyh eknyaaalet ftegqkldie tgfhrvgqag lqlltssdpp aldsqsagit
       61 gadanfsvwi krcqeaqngs esevwthqsk ikydwyqtes qvvitlmikn vqkndvnvef
      121 sekelsalvk lpsgedynlk lellhpiipe qstfkvlstk ieiklkkpea vrweklegqg
      181 dvptpkqfva dvknlypsss pytrnwdklv geikeeekne klegdaalnr lfqqiysdgs
      241 devkramnks fmesggtvls tnwsdvgkrk veinppddme wkky
//
LOCUS       XP_047286022             277 aa            linear   PRI 05-AUG-2025
DEFINITION  protein SGT1 homolog isoform X3 [Homo sapiens].
ACCESSION   XP_047286022
VERSION     XP_047286022.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430066.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..277
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..277
                     /product="protein SGT1 homolog isoform X3"
                     /calculated_mol_wt=31544
     Region          8..277
                     /region_name="PLN03088"
                     /note="SGT1, suppressor of G2 allele of SKP1; Provisional"
                     /db_xref="CDD:215568"
     Region          22..52
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..277
                     /gene="SUGT1"
                     /gene_synonym="SGT1"
                     /coded_by="XM_047430066.1:287..1120"
                     /db_xref="GeneID:10910"
                     /db_xref="HGNC:HGNC:16987"
                     /db_xref="MIM:604098"
ORIGIN      
        1 mlsqkevava dakkslelnp nnstamlrkg iceyheknya aaletftegq kldsadanfs
       61 vwikrcqeaq ngsesevwth qskikydwyq tesqvvitlm iknvqkndvn vefsekelsa
      121 lvklpsgedy nlklellhpi ipeqstfkvl stkieiklkk peavrwekle gqgdvptpkq
      181 fvadvknlyp ssspytrnwd klvgeikeee kneklegdaa lnrlfqqiys dgsdevkram
      241 nksfmesggt vlstnwsdvg krkveinppd dmewkky
//
LOCUS       XP_047286023             561 aa            linear   PRI 05-AUG-2025
DEFINITION  RCC1 and BTB domain-containing protein 2 isoform X1 [Homo sapiens].
ACCESSION   XP_047286023
VERSION     XP_047286023.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430067.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..561
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..561
                     /product="RCC1 and BTB domain-containing protein 2 isoform
                     X1"
                     /calculated_mol_wt=61426
     Region          <81..345
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          384..500
                     /region_name="BTB_POZ_RCBTB2_CHC1L"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in RCC1 and BTB
                     domain-containing protein 2 (RCBTB2); cd18354"
                     /db_xref="CDD:349663"
     Region          497..561
                     /region_name="BACK_RCBTB2"
                     /note="BACK (BTB and C-terminal Kelch) domain found in
                     RCC1 and BTB domain-containing protein 2 (RCBTB2);
                     cd18529"
                     /db_xref="CDD:350604"
     CDS             1..561
                     /gene="RCBTB2"
                     /gene_synonym="CHC1L; RLG"
                     /coded_by="XM_047430067.1:1108..2793"
                     /db_xref="GeneID:1102"
                     /db_xref="HGNC:HGNC:1914"
                     /db_xref="MIM:603524"
ORIGIN      
        1 merravnlem shshsftcsl tntkpvqatl sslkmldvgk wpifslcsee elqlirqacv
       61 fgsagnevly ttvndeifvl gtnccgclgl gdvqstiepr rldslngkki aclsygsgph
      121 ivlattegev ftwghnaysq lgngttnhgl vpchistnls nkqvievacg syhslvltsd
      181 gevfawgynn sgqvgsgstv nqpiprrvtg clqnkvvvti acgqmccmav vdtgevyvwg
      241 yngngqlglg nsgnqptpcr vaalqgirvq rvacgyahtl vltdegqvya wgansygqlg
      301 tgnksnqsyp tpvtvekdri ieiaachsth tsaaktqggh vymwgqcrgq svilphlthf
      361 sctddvfacf atpavtwrll svepddhltv aeslkrefdn pdtadlkflv dgkyiyahkv
      421 llkircehfr ssledneddi vemsefsypv yrafleylyt dsislspeea vglldlatfy
      481 renrlkklcq qtikqgicee naiallsaav kydaqdleef cfrfcinhlt vvtqtsgfae
      541 mdhdllknfi skasrvgafk n
//
LOCUS       XP_011533196             556 aa            linear   PRI 05-AUG-2025
DEFINITION  RCC1 and BTB domain-containing protein 2 isoform X2 [Homo sapiens].
ACCESSION   XP_011533196
VERSION     XP_011533196.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534894.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..556
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..556
                     /product="RCC1 and BTB domain-containing protein 2 isoform
                     X2"
                     /calculated_mol_wt=60844
     Region          <76..340
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          379..495
                     /region_name="BTB_POZ_RCBTB2_CHC1L"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in RCC1 and BTB
                     domain-containing protein 2 (RCBTB2); cd18354"
                     /db_xref="CDD:349663"
     Region          492..556
                     /region_name="BACK_RCBTB2"
                     /note="BACK (BTB and C-terminal Kelch) domain found in
                     RCC1 and BTB domain-containing protein 2 (RCBTB2);
                     cd18529"
                     /db_xref="CDD:350604"
     CDS             1..556
                     /gene="RCBTB2"
                     /gene_synonym="CHC1L; RLG"
                     /coded_by="XM_011534894.4:93..1763"
                     /db_xref="GeneID:1102"
                     /db_xref="HGNC:HGNC:1914"
                     /db_xref="MIM:603524"
ORIGIN      
        1 msalprdlel snprekltkp vqatlsslkm ldvgkwpifs lcseeelqli rqacvfgsag
       61 nevlyttvnd eifvlgtncc gclglgdvqs tieprrldsl ngkkiaclsy gsgphivlat
      121 tegevftwgh naysqlgngt tnhglvpchi stnlsnkqvi evacgsyhsl vltsdgevfa
      181 wgynnsgqvg sgstvnqpip rrvtgclqnk vvvtiacgqm ccmavvdtge vyvwgyngng
      241 qlglgnsgnq ptpcrvaalq girvqrvacg yahtlvltde gqvyawgans ygqlgtgnks
      301 nqsyptpvtv ekdriieiaa chsthtsaak tqgghvymwg qcrgqsvilp hlthfsctdd
      361 vfacfatpav twrllsvepd dhltvaeslk refdnpdtad lkflvdgkyi yahkvllkir
      421 cehfrssled neddivemse fsypvyrafl eylytdsisl speeavglld latfyrenrl
      481 kklcqqtikq giceenaial lsaavkydaq dleefcfrfc inhltvvtqt sgfaemdhdl
      541 lknfiskasr vgafkn
//
LOCUS       XP_047286024             324 aa            linear   PRI 05-AUG-2025
DEFINITION  RCC1 and BTB domain-containing protein 2 isoform X3 [Homo sapiens].
ACCESSION   XP_047286024
VERSION     XP_047286024.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430068.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..324
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..324
                     /product="RCC1 and BTB domain-containing protein 2 isoform
                     X3"
                     /calculated_mol_wt=34480
     Region          <81..314
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     CDS             1..324
                     /gene="RCBTB2"
                     /gene_synonym="CHC1L; RLG"
                     /coded_by="XM_047430068.1:1108..2082"
                     /db_xref="GeneID:1102"
                     /db_xref="HGNC:HGNC:1914"
                     /db_xref="MIM:603524"
ORIGIN      
        1 merravnlem shshsftcsl tntkpvqatl sslkmldvgk wpifslcsee elqlirqacv
       61 fgsagnevly ttvndeifvl gtnccgclgl gdvqstiepr rldslngkki aclsygsgph
      121 ivlattegev ftwghnaysq lgngttnhgl vpchistnls nkqvievacg syhslvltsd
      181 gevfawgynn sgqvgsgstv nqpiprrvtg clqnkvvvti acgqmccmav vdtgevyvwg
      241 yngngqlglg nsgnqptpcr vaalqgirvq rvacgyahtl vltdegqvya wgansygqlg
      301 tgnksnqsyp tpvtvekdrv cgqn
//
LOCUS       XP_047286025             315 aa            linear   PRI 05-AUG-2025
DEFINITION  RCC1 and BTB domain-containing protein 2 isoform X4 [Homo sapiens].
ACCESSION   XP_047286025
VERSION     XP_047286025.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430069.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..315
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..315
                     /product="RCC1 and BTB domain-containing protein 2 isoform
                     X4"
                     /calculated_mol_wt=33595
     Region          <81..>268
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     CDS             1..315
                     /gene="RCBTB2"
                     /gene_synonym="CHC1L; RLG"
                     /coded_by="XM_047430069.1:1108..2055"
                     /db_xref="GeneID:1102"
                     /db_xref="HGNC:HGNC:1914"
                     /db_xref="MIM:603524"
ORIGIN      
        1 merravnlem shshsftcsl tntkpvqatl sslkmldvgk wpifslcsee elqlirqacv
       61 fgsagnevly ttvndeifvl gtnccgclgl gdvqstiepr rldslngkki aclsygsgph
      121 ivlattegev ftwghnaysq lgngttnhgl vpchistnls nkqvievacg syhslvltsd
      181 gevfawgynn sgqvgsgstv nqpiprrvtg clqnkvvvti acgqmccmav vdtgevyvwg
      241 yngngqlglg nsgnqptpcr vaalqgirvq rdyrdcslsl hthvcgqdag warvhvgpvp
      301 gsvrdppaph plllh
//
LOCUS       XP_011533199             365 aa            linear   PRI 05-AUG-2025
DEFINITION  leukocyte cell-derived chemotaxin 1 isoform X1 [Homo sapiens].
ACCESSION   XP_011533199
VERSION     XP_011533199.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534897.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..365
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..365
                     /product="leukocyte cell-derived chemotaxin 1 isoform X1"
                     /calculated_mol_wt=40175
     Region          131..228
                     /region_name="BRICHOS"
                     /note="The BRICHOS domain is found in a variety of
                     proteins implicated in dementia, respiratory distress and
                     cancer; smart01039"
                     /db_xref="CDD:198107"
     CDS             1..365
                     /gene="CNMD"
                     /gene_synonym="BRICD3; CHM-I; CHM1; LECT1; MYETS1"
                     /coded_by="XM_011534897.3:39..1136"
                     /db_xref="GeneID:11061"
                     /db_xref="HGNC:HGNC:17005"
                     /db_xref="MIM:605147"
ORIGIN      
        1 mpctsgqrdr sqgaqgvskc ltppaanmte nsdkvpialv gpddvefcsp payatltvkp
       61 ssparllkvg avvlisgavl llfgaigafy fwkgsdshiy nvhytmsing klqdgsmeid
      121 agnnletfkm gsgaeeaiav ndfqngitgi rfaggekcyi kaqvkaripe vgavtkqsis
      181 sklegkimpv kyeensliwv avdqpvkdns flsskvlelc gdlpifwlkp typkeifaei
      241 qrerrevvrk ivptttkrph sgprsnpgag rlnnetrpsv qedsqafnpd npyhqqeges
      301 mtfdprldhe gicciecrrs ythcqkicep lggyypwpyn yqgcrsacrv impcswwvar
      361 ilgmv
//
LOCUS       XP_011533200             364 aa            linear   PRI 05-AUG-2025
DEFINITION  leukocyte cell-derived chemotaxin 1 isoform X2 [Homo sapiens].
ACCESSION   XP_011533200
VERSION     XP_011533200.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534898.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..364
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..364
                     /product="leukocyte cell-derived chemotaxin 1 isoform X2"
                     /calculated_mol_wt=40047
     Region          131..228
                     /region_name="BRICHOS"
                     /note="The BRICHOS domain is found in a variety of
                     proteins implicated in dementia, respiratory distress and
                     cancer; smart01039"
                     /db_xref="CDD:198107"
     CDS             1..364
                     /gene="CNMD"
                     /gene_synonym="BRICD3; CHM-I; CHM1; LECT1; MYETS1"
                     /coded_by="XM_011534898.3:39..1133"
                     /db_xref="GeneID:11061"
                     /db_xref="HGNC:HGNC:17005"
                     /db_xref="MIM:605147"
ORIGIN      
        1 mpctsgqrdr sqgaqgvskc ltppaanmte nsdkvpialv gpddvefcsp payatltvkp
       61 ssparllkvg avvlisgavl llfgaigafy fwkgsdshiy nvhytmsing klqdgsmeid
      121 agnnletfkm gsgaeeaiav ndfqngitgi rfaggekcyi kaqvkaripe vgavtkqsis
      181 sklegkimpv kyeensliwv avdqpvkdns flsskvlelc gdlpifwlkp typkeifaei
      241 qrerrevvrk ivptttkrph sgprsnpgag rlnnetrpsv qedsqafnpd npyhqegesm
      301 tfdprldheg icciecrrsy thcqkicepl ggyypwpyny qgcrsacrvi mpcswwvari
      361 lgmv
//
LOCUS       XP_011533201             327 aa            linear   PRI 05-AUG-2025
DEFINITION  leukocyte cell-derived chemotaxin 1 isoform X3 [Homo sapiens].
ACCESSION   XP_011533201
VERSION     XP_011533201.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534899.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..327
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..327
                     /product="leukocyte cell-derived chemotaxin 1 isoform X3"
                     /calculated_mol_wt=36187
     Region          131..190
                     /region_name="BRICHOS"
                     /note="BRICHOS domain; cl04394"
                     /db_xref="CDD:471013"
     CDS             1..327
                     /gene="CNMD"
                     /gene_synonym="BRICD3; CHM-I; CHM1; LECT1; MYETS1"
                     /coded_by="XM_011534899.3:39..1022"
                     /db_xref="GeneID:11061"
                     /db_xref="HGNC:HGNC:17005"
                     /db_xref="MIM:605147"
ORIGIN      
        1 mpctsgqrdr sqgaqgvskc ltppaanmte nsdkvpialv gpddvefcsp payatltvkp
       61 ssparllkvg avvlisgavl llfgaigafy fwkgsdshiy nvhytmsing klqdgsmeid
      121 agnnletfkm gsgaeeaiav ndfqnegkim pvkyeensli wvavdqpvkd nsflsskvle
      181 lcgdlpifwl kptypkeifa eiqrerrevv rkivptttkr phsgprsnpg agrlnnetrp
      241 svqedsqafn pdnpyhqqeg esmtfdprld hegicciecr rsythcqkic eplggyypwp
      301 ynyqgcrsac rvimpcswwv arilgmv
//
LOCUS       XP_011533202             323 aa            linear   PRI 05-AUG-2025
DEFINITION  leukocyte cell-derived chemotaxin 1 isoform X4 [Homo sapiens].
ACCESSION   XP_011533202
VERSION     XP_011533202.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534900.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..323
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..323
                     /product="leukocyte cell-derived chemotaxin 1 isoform X4"
                     /calculated_mol_wt=35727
     Region          131..190
                     /region_name="BRICHOS"
                     /note="BRICHOS domain; cl04394"
                     /db_xref="CDD:471013"
     CDS             1..323
                     /gene="CNMD"
                     /gene_synonym="BRICD3; CHM-I; CHM1; LECT1; MYETS1"
                     /coded_by="XM_011534900.3:39..1010"
                     /db_xref="GeneID:11061"
                     /db_xref="HGNC:HGNC:17005"
                     /db_xref="MIM:605147"
ORIGIN      
        1 mpctsgqrdr sqgaqgvskc ltppaanmte nsdkvpialv gpddvefcsp payatltvkp
       61 ssparllkvg avvlisgavl llfgaigafy fwkgsdshiy nvhytmsing klqdgsmeid
      121 agnnletfkm gsgaeeaiav ndfqnegkim pvkyeensli wvavdqpvkd nsflsskvle
      181 lcgdlpifwl kptypkeiqr errevvrkiv ptttkrphsg prsnpgagrl nnetrpsvqe
      241 dsqafnpdnp yhqqegesmt fdprldhegi cciecrrsyt hcqkiceplg gyypwpynyq
      301 gcrsacrvim pcswwvaril gmv
//
LOCUS       XP_047286026             322 aa            linear   PRI 05-AUG-2025
DEFINITION  leukocyte cell-derived chemotaxin 1 isoform X5 [Homo sapiens].
ACCESSION   XP_047286026
VERSION     XP_047286026.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430070.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..322
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..322
                     /product="leukocyte cell-derived chemotaxin 1 isoform X5"
                     /calculated_mol_wt=35599
     Region          131..190
                     /region_name="BRICHOS"
                     /note="BRICHOS domain; cl04394"
                     /db_xref="CDD:471013"
     CDS             1..322
                     /gene="CNMD"
                     /gene_synonym="BRICD3; CHM-I; CHM1; LECT1; MYETS1"
                     /coded_by="XM_047430070.1:39..1007"
                     /db_xref="GeneID:11061"
                     /db_xref="HGNC:HGNC:17005"
                     /db_xref="MIM:605147"
ORIGIN      
        1 mpctsgqrdr sqgaqgvskc ltppaanmte nsdkvpialv gpddvefcsp payatltvkp
       61 ssparllkvg avvlisgavl llfgaigafy fwkgsdshiy nvhytmsing klqdgsmeid
      121 agnnletfkm gsgaeeaiav ndfqnegkim pvkyeensli wvavdqpvkd nsflsskvle
      181 lcgdlpifwl kptypkeiqr errevvrkiv ptttkrphsg prsnpgagrl nnetrpsvqe
      241 dsqafnpdnp yhqegesmtf dprldhegic ciecrrsyth cqkiceplgg yypwpynyqg
      301 crsacrvimp cswwvarilg mv
//
LOCUS       XP_005266302             407 aa            linear   PRI 05-AUG-2025
DEFINITION  WW domain-binding protein 4 isoform X1 [Homo sapiens].
ACCESSION   XP_005266302
VERSION     XP_005266302.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266245.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..407
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..407
                     /product="WW domain-binding protein 4 isoform X1"
                     /calculated_mol_wt=45710
     Region          39..75
                     /region_name="zf-U1"
                     /note="U1 zinc finger; pfam06220"
                     /db_xref="CDD:368798"
     Region          159..>227
                     /region_name="PRP40"
                     /note="Splicing factor [RNA processing and modification];
                     COG5104"
                     /db_xref="CDD:227435"
     CDS             1..407
                     /gene="WBP4"
                     /gene_synonym="FBP21; NEDHFDB"
                     /coded_by="XM_005266245.3:21..1244"
                     /db_xref="GeneID:11193"
                     /db_xref="HGNC:HGNC:12739"
                     /db_xref="MIM:604981"
ORIGIN      
        1 mafpvlscle aqeqfvltes lggttvfprv vladywksqp kkfcdyckcw iadnrpsvef
       61 hergknhken vakriseikq ksldkakeee kaskefaame aaalkayqed lkrlglesei
      121 lepsitpvts tipptstsnq qkekkekkkr kkdpskgrwv egitsegyhy yydlisgasq
      181 wekpegfqgd lkktavktvw veglsedgft yyyntetges rwekpddfip htsdlpsskv
      241 nenslgtlde skssdshsds dgeqeaeegg vstetekpki kfkeknknsd ggsdpetqke
      301 ksiqkqnslg sneeksktlk ksnpygewqe ikqeveshee vdlelpsten eyvstseadg
      361 ggepkvvfke ktvtslgvma dgvapvfkkr rtengksrnl rqrgddq
//
LOCUS       XP_047286027             220 aa            linear   PRI 05-AUG-2025
DEFINITION  WW domain-binding protein 4 isoform X2 [Homo sapiens].
ACCESSION   XP_047286027
VERSION     XP_047286027.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430071.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..220
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..220
                     /product="WW domain-binding protein 4 isoform X2"
                     /calculated_mol_wt=24374
     Region          13..38
                     /region_name="WW"
                     /note="WW domain; pfam00397"
                     /db_xref="CDD:459800"
     CDS             1..220
                     /gene="WBP4"
                     /gene_synonym="FBP21; NEDHFDB"
                     /coded_by="XM_047430071.1:64..726"
                     /db_xref="GeneID:11193"
                     /db_xref="HGNC:HGNC:12739"
                     /db_xref="MIM:604981"
ORIGIN      
        1 milsqetavk tvwveglsed gftyyyntet gesrwekpdd fiphtsdlps skvnenslgt
       61 ldeskssdsh sdsdgeqeae eggvstetek pkikfkeknk nsdggsdpet qkeksiqkqn
      121 slgsneeksk tlkksnpyge wqeikqeves heevdlelps teneyvstse adgggepkvv
      181 fkektvtslg vmadgvapvf kkrrtengks rnlrqrgddq
//
LOCUS       XP_011533205            1901 aa            linear   PRI 05-AUG-2025
DEFINITION  A-kinase anchor protein 11 isoform X1 [Homo sapiens].
ACCESSION   XP_011533205
VERSION     XP_011533205.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534903.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1901
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1901
                     /product="A-kinase anchor protein 11 isoform X1"
                     /calculated_mol_wt=210382
     Region          <1804..1900
                     /region_name="AKAP_110"
                     /note="A-kinase anchor protein 110 kDa (AKAP 110);
                     cl14906"
                     /db_xref="CDD:449376"
     CDS             1..1901
                     /gene="AKAP11"
                     /gene_synonym="AKAP-11; AKAP220; PPP1R44; PRKA11"
                     /coded_by="XM_011534903.3:162..5867"
                     /db_xref="GeneID:11215"
                     /db_xref="HGNC:HGNC:369"
                     /db_xref="MIM:604696"
ORIGIN      
        1 matfrnnhmk tkasvrksfs edvfqsvksl lqsqkelcsv taedclqqde hanltevtfl
       61 gfneetdaah iqdlaavsle lpdilnslhf cslneneiic mkninkpldi ssdplnqshp
      121 sgmlcvmrvs ptsprlridf ifsllskyat girytldtfl hqkhqlettd eddddtnqsv
      181 ssieddfvta fehleeeets kpyndgmnit vlrsqcdaas qtvtghhlet hdlkilissg
      241 qqkslakpst ssvnvlghke lpsvktsvtt sisepwtqrs fyrssnasdk dsdlqktffs
      301 sspayssese csspspvifl deegyqkslk aklelpkipv mkddiedsds evseffdsfd
      361 qfdeleqtle tclfnkdpvi gkssqrkghk hgkscmnpqk fkfdrpalpa nvrkptprkp
      421 espygnlcda pdsprpvkas redsglfspi rssafsplgg ctpaecfcqt diggdrihen
      481 hdsvyytyed yaksiscevl gsvlrthhtn tlsninsikh genktvtfkh gnldqknksk
      541 nkslmikdsi qkfaadlvek sfgsafkdlq kgvssctnal yhlaikltss vlqmafdelr
      601 rqrafslker aisglanflv sealsnalkd lqyvkkqift ntvarfaadl aeelvfegim
      661 evcqfsypqt paspqcgsfd fedkvvklya kdlsesviqe afielsqvdv tfttkaavsv
      721 stdnikyvsa esvvpstqav tfspsfhnqa imvtkpvqey kkeytvqqal fctsgivtsi
      781 pvplagsall pyhisstacq akahlssdds nsngdsaqvh iatknreeka aclrniclps
      841 ehnpgnqndf kptnddiemq sssklpndpa iisnfsaavv htivnetles mtslevtkmv
      901 dertdyltks lkektppfsh cdqavlqcse assnkdmfad rlsksiikhs idksksvipn
      961 idknavykes lpvsgeesql tpekspkfpd sqnqlthcsl saakdcvpec kvsmvhgssl
     1021 etlpscpavt gqksdlkesa kdqplkkhnl nstslealsf gqenpfphsh tfsstaltcv
     1081 dglhvedkqk vrdrnvipdt ppstplvpsr assewdikkl tkklkgelak efapatppst
     1141 phnssvgsls eneqntieke efmlklmrsl seevessesg elpevdvkse hsgkkvqfae
     1201 alathilsla temaashldn kiiqepkvkn pclnvqsqrs vsptflnpsd enlktlcnfa
     1261 gdlaaevite aekiakvrnc mlfkqkknsc yadgdedykv eekldieavv hprevdpfil
     1321 slppsscmsg lmykypsces vtdeyaghli qilkqeggns elimdqyanr layrsvksgl
     1381 qeaakttkvq cnsrmfpvps sqvktnkell mfsnkehhqe adkkrqskrn egyfcknqtc
     1441 ertldpyrne vsqlysfsts lvhsitkdak eeltaslvgl pksltdsclf eksgyeedne
     1501 chvtpelpks lqpssqnhrf yhstgslngy gcgdnvvqav eqyakkvvdd tleltlgstv
     1561 frvsettksa drvtyaekls pltgqacryc dlkelhnctg nssqhffrqg slasskpasn
     1621 pkfssryqks rifhlsvpqi hvnldkkavl aekivaeaie kaerelssts laadsgigqe
     1681 gasfaeslat etmtaavtnv ghavssskei edfqstesvs sqqmnlsigd dstgswsnls
     1741 fedehqdess sfhhlsesng nssswsslgl egdlyednls fptsdsdgpd dkdeehedev
     1801 eglgqdgktl litnidmepc tvdpqlriil qwliaseaev aelyfhdsan kefmllskql
     1861 qekgwkvgdl lqavlqyyev mekasseerc kslfdwllen a
//
LOCUS       XP_011533206            1901 aa            linear   PRI 05-AUG-2025
DEFINITION  A-kinase anchor protein 11 isoform X1 [Homo sapiens].
ACCESSION   XP_011533206
VERSION     XP_011533206.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534904.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1901
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1901
                     /product="A-kinase anchor protein 11 isoform X1"
                     /calculated_mol_wt=210382
     Region          <1804..1900
                     /region_name="AKAP_110"
                     /note="A-kinase anchor protein 110 kDa (AKAP 110);
                     cl14906"
                     /db_xref="CDD:449376"
     CDS             1..1901
                     /gene="AKAP11"
                     /gene_synonym="AKAP-11; AKAP220; PPP1R44; PRKA11"
                     /coded_by="XM_011534904.2:388..6093"
                     /db_xref="GeneID:11215"
                     /db_xref="HGNC:HGNC:369"
                     /db_xref="MIM:604696"
ORIGIN      
        1 matfrnnhmk tkasvrksfs edvfqsvksl lqsqkelcsv taedclqqde hanltevtfl
       61 gfneetdaah iqdlaavsle lpdilnslhf cslneneiic mkninkpldi ssdplnqshp
      121 sgmlcvmrvs ptsprlridf ifsllskyat girytldtfl hqkhqlettd eddddtnqsv
      181 ssieddfvta fehleeeets kpyndgmnit vlrsqcdaas qtvtghhlet hdlkilissg
      241 qqkslakpst ssvnvlghke lpsvktsvtt sisepwtqrs fyrssnasdk dsdlqktffs
      301 sspayssese csspspvifl deegyqkslk aklelpkipv mkddiedsds evseffdsfd
      361 qfdeleqtle tclfnkdpvi gkssqrkghk hgkscmnpqk fkfdrpalpa nvrkptprkp
      421 espygnlcda pdsprpvkas redsglfspi rssafsplgg ctpaecfcqt diggdrihen
      481 hdsvyytyed yaksiscevl gsvlrthhtn tlsninsikh genktvtfkh gnldqknksk
      541 nkslmikdsi qkfaadlvek sfgsafkdlq kgvssctnal yhlaikltss vlqmafdelr
      601 rqrafslker aisglanflv sealsnalkd lqyvkkqift ntvarfaadl aeelvfegim
      661 evcqfsypqt paspqcgsfd fedkvvklya kdlsesviqe afielsqvdv tfttkaavsv
      721 stdnikyvsa esvvpstqav tfspsfhnqa imvtkpvqey kkeytvqqal fctsgivtsi
      781 pvplagsall pyhisstacq akahlssdds nsngdsaqvh iatknreeka aclrniclps
      841 ehnpgnqndf kptnddiemq sssklpndpa iisnfsaavv htivnetles mtslevtkmv
      901 dertdyltks lkektppfsh cdqavlqcse assnkdmfad rlsksiikhs idksksvipn
      961 idknavykes lpvsgeesql tpekspkfpd sqnqlthcsl saakdcvpec kvsmvhgssl
     1021 etlpscpavt gqksdlkesa kdqplkkhnl nstslealsf gqenpfphsh tfsstaltcv
     1081 dglhvedkqk vrdrnvipdt ppstplvpsr assewdikkl tkklkgelak efapatppst
     1141 phnssvgsls eneqntieke efmlklmrsl seevessesg elpevdvkse hsgkkvqfae
     1201 alathilsla temaashldn kiiqepkvkn pclnvqsqrs vsptflnpsd enlktlcnfa
     1261 gdlaaevite aekiakvrnc mlfkqkknsc yadgdedykv eekldieavv hprevdpfil
     1321 slppsscmsg lmykypsces vtdeyaghli qilkqeggns elimdqyanr layrsvksgl
     1381 qeaakttkvq cnsrmfpvps sqvktnkell mfsnkehhqe adkkrqskrn egyfcknqtc
     1441 ertldpyrne vsqlysfsts lvhsitkdak eeltaslvgl pksltdsclf eksgyeedne
     1501 chvtpelpks lqpssqnhrf yhstgslngy gcgdnvvqav eqyakkvvdd tleltlgstv
     1561 frvsettksa drvtyaekls pltgqacryc dlkelhnctg nssqhffrqg slasskpasn
     1621 pkfssryqks rifhlsvpqi hvnldkkavl aekivaeaie kaerelssts laadsgigqe
     1681 gasfaeslat etmtaavtnv ghavssskei edfqstesvs sqqmnlsigd dstgswsnls
     1741 fedehqdess sfhhlsesng nssswsslgl egdlyednls fptsdsdgpd dkdeehedev
     1801 eglgqdgktl litnidmepc tvdpqlriil qwliaseaev aelyfhdsan kefmllskql
     1861 qekgwkvgdl lqavlqyyev mekasseerc kslfdwllen a
//
LOCUS       XP_011533207            1901 aa            linear   PRI 05-AUG-2025
DEFINITION  A-kinase anchor protein 11 isoform X1 [Homo sapiens].
ACCESSION   XP_011533207
VERSION     XP_011533207.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534905.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1901
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1901
                     /product="A-kinase anchor protein 11 isoform X1"
                     /calculated_mol_wt=210382
     Region          <1804..1900
                     /region_name="AKAP_110"
                     /note="A-kinase anchor protein 110 kDa (AKAP 110);
                     cl14906"
                     /db_xref="CDD:449376"
     CDS             1..1901
                     /gene="AKAP11"
                     /gene_synonym="AKAP-11; AKAP220; PPP1R44; PRKA11"
                     /coded_by="XM_011534905.2:127..5832"
                     /db_xref="GeneID:11215"
                     /db_xref="HGNC:HGNC:369"
                     /db_xref="MIM:604696"
ORIGIN      
        1 matfrnnhmk tkasvrksfs edvfqsvksl lqsqkelcsv taedclqqde hanltevtfl
       61 gfneetdaah iqdlaavsle lpdilnslhf cslneneiic mkninkpldi ssdplnqshp
      121 sgmlcvmrvs ptsprlridf ifsllskyat girytldtfl hqkhqlettd eddddtnqsv
      181 ssieddfvta fehleeeets kpyndgmnit vlrsqcdaas qtvtghhlet hdlkilissg
      241 qqkslakpst ssvnvlghke lpsvktsvtt sisepwtqrs fyrssnasdk dsdlqktffs
      301 sspayssese csspspvifl deegyqkslk aklelpkipv mkddiedsds evseffdsfd
      361 qfdeleqtle tclfnkdpvi gkssqrkghk hgkscmnpqk fkfdrpalpa nvrkptprkp
      421 espygnlcda pdsprpvkas redsglfspi rssafsplgg ctpaecfcqt diggdrihen
      481 hdsvyytyed yaksiscevl gsvlrthhtn tlsninsikh genktvtfkh gnldqknksk
      541 nkslmikdsi qkfaadlvek sfgsafkdlq kgvssctnal yhlaikltss vlqmafdelr
      601 rqrafslker aisglanflv sealsnalkd lqyvkkqift ntvarfaadl aeelvfegim
      661 evcqfsypqt paspqcgsfd fedkvvklya kdlsesviqe afielsqvdv tfttkaavsv
      721 stdnikyvsa esvvpstqav tfspsfhnqa imvtkpvqey kkeytvqqal fctsgivtsi
      781 pvplagsall pyhisstacq akahlssdds nsngdsaqvh iatknreeka aclrniclps
      841 ehnpgnqndf kptnddiemq sssklpndpa iisnfsaavv htivnetles mtslevtkmv
      901 dertdyltks lkektppfsh cdqavlqcse assnkdmfad rlsksiikhs idksksvipn
      961 idknavykes lpvsgeesql tpekspkfpd sqnqlthcsl saakdcvpec kvsmvhgssl
     1021 etlpscpavt gqksdlkesa kdqplkkhnl nstslealsf gqenpfphsh tfsstaltcv
     1081 dglhvedkqk vrdrnvipdt ppstplvpsr assewdikkl tkklkgelak efapatppst
     1141 phnssvgsls eneqntieke efmlklmrsl seevessesg elpevdvkse hsgkkvqfae
     1201 alathilsla temaashldn kiiqepkvkn pclnvqsqrs vsptflnpsd enlktlcnfa
     1261 gdlaaevite aekiakvrnc mlfkqkknsc yadgdedykv eekldieavv hprevdpfil
     1321 slppsscmsg lmykypsces vtdeyaghli qilkqeggns elimdqyanr layrsvksgl
     1381 qeaakttkvq cnsrmfpvps sqvktnkell mfsnkehhqe adkkrqskrn egyfcknqtc
     1441 ertldpyrne vsqlysfsts lvhsitkdak eeltaslvgl pksltdsclf eksgyeedne
     1501 chvtpelpks lqpssqnhrf yhstgslngy gcgdnvvqav eqyakkvvdd tleltlgstv
     1561 frvsettksa drvtyaekls pltgqacryc dlkelhnctg nssqhffrqg slasskpasn
     1621 pkfssryqks rifhlsvpqi hvnldkkavl aekivaeaie kaerelssts laadsgigqe
     1681 gasfaeslat etmtaavtnv ghavssskei edfqstesvs sqqmnlsigd dstgswsnls
     1741 fedehqdess sfhhlsesng nssswsslgl egdlyednls fptsdsdgpd dkdeehedev
     1801 eglgqdgktl litnidmepc tvdpqlriil qwliaseaev aelyfhdsan kefmllskql
     1861 qekgwkvgdl lqavlqyyev mekasseerc kslfdwllen a
//
LOCUS       XP_011533208            1901 aa            linear   PRI 05-AUG-2025
DEFINITION  A-kinase anchor protein 11 isoform X1 [Homo sapiens].
ACCESSION   XP_011533208
VERSION     XP_011533208.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534906.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1901
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1901
                     /product="A-kinase anchor protein 11 isoform X1"
                     /calculated_mol_wt=210382
     Region          <1804..1900
                     /region_name="AKAP_110"
                     /note="A-kinase anchor protein 110 kDa (AKAP 110);
                     cl14906"
                     /db_xref="CDD:449376"
     CDS             1..1901
                     /gene="AKAP11"
                     /gene_synonym="AKAP-11; AKAP220; PPP1R44; PRKA11"
                     /coded_by="XM_011534906.3:338..6043"
                     /db_xref="GeneID:11215"
                     /db_xref="HGNC:HGNC:369"
                     /db_xref="MIM:604696"
ORIGIN      
        1 matfrnnhmk tkasvrksfs edvfqsvksl lqsqkelcsv taedclqqde hanltevtfl
       61 gfneetdaah iqdlaavsle lpdilnslhf cslneneiic mkninkpldi ssdplnqshp
      121 sgmlcvmrvs ptsprlridf ifsllskyat girytldtfl hqkhqlettd eddddtnqsv
      181 ssieddfvta fehleeeets kpyndgmnit vlrsqcdaas qtvtghhlet hdlkilissg
      241 qqkslakpst ssvnvlghke lpsvktsvtt sisepwtqrs fyrssnasdk dsdlqktffs
      301 sspayssese csspspvifl deegyqkslk aklelpkipv mkddiedsds evseffdsfd
      361 qfdeleqtle tclfnkdpvi gkssqrkghk hgkscmnpqk fkfdrpalpa nvrkptprkp
      421 espygnlcda pdsprpvkas redsglfspi rssafsplgg ctpaecfcqt diggdrihen
      481 hdsvyytyed yaksiscevl gsvlrthhtn tlsninsikh genktvtfkh gnldqknksk
      541 nkslmikdsi qkfaadlvek sfgsafkdlq kgvssctnal yhlaikltss vlqmafdelr
      601 rqrafslker aisglanflv sealsnalkd lqyvkkqift ntvarfaadl aeelvfegim
      661 evcqfsypqt paspqcgsfd fedkvvklya kdlsesviqe afielsqvdv tfttkaavsv
      721 stdnikyvsa esvvpstqav tfspsfhnqa imvtkpvqey kkeytvqqal fctsgivtsi
      781 pvplagsall pyhisstacq akahlssdds nsngdsaqvh iatknreeka aclrniclps
      841 ehnpgnqndf kptnddiemq sssklpndpa iisnfsaavv htivnetles mtslevtkmv
      901 dertdyltks lkektppfsh cdqavlqcse assnkdmfad rlsksiikhs idksksvipn
      961 idknavykes lpvsgeesql tpekspkfpd sqnqlthcsl saakdcvpec kvsmvhgssl
     1021 etlpscpavt gqksdlkesa kdqplkkhnl nstslealsf gqenpfphsh tfsstaltcv
     1081 dglhvedkqk vrdrnvipdt ppstplvpsr assewdikkl tkklkgelak efapatppst
     1141 phnssvgsls eneqntieke efmlklmrsl seevessesg elpevdvkse hsgkkvqfae
     1201 alathilsla temaashldn kiiqepkvkn pclnvqsqrs vsptflnpsd enlktlcnfa
     1261 gdlaaevite aekiakvrnc mlfkqkknsc yadgdedykv eekldieavv hprevdpfil
     1321 slppsscmsg lmykypsces vtdeyaghli qilkqeggns elimdqyanr layrsvksgl
     1381 qeaakttkvq cnsrmfpvps sqvktnkell mfsnkehhqe adkkrqskrn egyfcknqtc
     1441 ertldpyrne vsqlysfsts lvhsitkdak eeltaslvgl pksltdsclf eksgyeedne
     1501 chvtpelpks lqpssqnhrf yhstgslngy gcgdnvvqav eqyakkvvdd tleltlgstv
     1561 frvsettksa drvtyaekls pltgqacryc dlkelhnctg nssqhffrqg slasskpasn
     1621 pkfssryqks rifhlsvpqi hvnldkkavl aekivaeaie kaerelssts laadsgigqe
     1681 gasfaeslat etmtaavtnv ghavssskei edfqstesvs sqqmnlsigd dstgswsnls
     1741 fedehqdess sfhhlsesng nssswsslgl egdlyednls fptsdsdgpd dkdeehedev
     1801 eglgqdgktl litnidmepc tvdpqlriil qwliaseaev aelyfhdsan kefmllskql
     1861 qekgwkvgdl lqavlqyyev mekasseerc kslfdwllen a
//
LOCUS       XP_016875870            1901 aa            linear   PRI 05-AUG-2025
DEFINITION  A-kinase anchor protein 11 isoform X1 [Homo sapiens].
ACCESSION   XP_016875870
VERSION     XP_016875870.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020381.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1901
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1901
                     /product="A-kinase anchor protein 11 isoform X1"
                     /calculated_mol_wt=210382
     Region          <1804..1900
                     /region_name="AKAP_110"
                     /note="A-kinase anchor protein 110 kDa (AKAP 110);
                     cl14906"
                     /db_xref="CDD:449376"
     CDS             1..1901
                     /gene="AKAP11"
                     /gene_synonym="AKAP-11; AKAP220; PPP1R44; PRKA11"
                     /coded_by="XM_017020381.3:710..6415"
                     /db_xref="GeneID:11215"
                     /db_xref="HGNC:HGNC:369"
                     /db_xref="MIM:604696"
ORIGIN      
        1 matfrnnhmk tkasvrksfs edvfqsvksl lqsqkelcsv taedclqqde hanltevtfl
       61 gfneetdaah iqdlaavsle lpdilnslhf cslneneiic mkninkpldi ssdplnqshp
      121 sgmlcvmrvs ptsprlridf ifsllskyat girytldtfl hqkhqlettd eddddtnqsv
      181 ssieddfvta fehleeeets kpyndgmnit vlrsqcdaas qtvtghhlet hdlkilissg
      241 qqkslakpst ssvnvlghke lpsvktsvtt sisepwtqrs fyrssnasdk dsdlqktffs
      301 sspayssese csspspvifl deegyqkslk aklelpkipv mkddiedsds evseffdsfd
      361 qfdeleqtle tclfnkdpvi gkssqrkghk hgkscmnpqk fkfdrpalpa nvrkptprkp
      421 espygnlcda pdsprpvkas redsglfspi rssafsplgg ctpaecfcqt diggdrihen
      481 hdsvyytyed yaksiscevl gsvlrthhtn tlsninsikh genktvtfkh gnldqknksk
      541 nkslmikdsi qkfaadlvek sfgsafkdlq kgvssctnal yhlaikltss vlqmafdelr
      601 rqrafslker aisglanflv sealsnalkd lqyvkkqift ntvarfaadl aeelvfegim
      661 evcqfsypqt paspqcgsfd fedkvvklya kdlsesviqe afielsqvdv tfttkaavsv
      721 stdnikyvsa esvvpstqav tfspsfhnqa imvtkpvqey kkeytvqqal fctsgivtsi
      781 pvplagsall pyhisstacq akahlssdds nsngdsaqvh iatknreeka aclrniclps
      841 ehnpgnqndf kptnddiemq sssklpndpa iisnfsaavv htivnetles mtslevtkmv
      901 dertdyltks lkektppfsh cdqavlqcse assnkdmfad rlsksiikhs idksksvipn
      961 idknavykes lpvsgeesql tpekspkfpd sqnqlthcsl saakdcvpec kvsmvhgssl
     1021 etlpscpavt gqksdlkesa kdqplkkhnl nstslealsf gqenpfphsh tfsstaltcv
     1081 dglhvedkqk vrdrnvipdt ppstplvpsr assewdikkl tkklkgelak efapatppst
     1141 phnssvgsls eneqntieke efmlklmrsl seevessesg elpevdvkse hsgkkvqfae
     1201 alathilsla temaashldn kiiqepkvkn pclnvqsqrs vsptflnpsd enlktlcnfa
     1261 gdlaaevite aekiakvrnc mlfkqkknsc yadgdedykv eekldieavv hprevdpfil
     1321 slppsscmsg lmykypsces vtdeyaghli qilkqeggns elimdqyanr layrsvksgl
     1381 qeaakttkvq cnsrmfpvps sqvktnkell mfsnkehhqe adkkrqskrn egyfcknqtc
     1441 ertldpyrne vsqlysfsts lvhsitkdak eeltaslvgl pksltdsclf eksgyeedne
     1501 chvtpelpks lqpssqnhrf yhstgslngy gcgdnvvqav eqyakkvvdd tleltlgstv
     1561 frvsettksa drvtyaekls pltgqacryc dlkelhnctg nssqhffrqg slasskpasn
     1621 pkfssryqks rifhlsvpqi hvnldkkavl aekivaeaie kaerelssts laadsgigqe
     1681 gasfaeslat etmtaavtnv ghavssskei edfqstesvs sqqmnlsigd dstgswsnls
     1741 fedehqdess sfhhlsesng nssswsslgl egdlyednls fptsdsdgpd dkdeehedev
     1801 eglgqdgktl litnidmepc tvdpqlriil qwliaseaev aelyfhdsan kefmllskql
     1861 qekgwkvgdl lqavlqyyev mekasseerc kslfdwllen a
//
LOCUS       XP_005266304            1873 aa            linear   PRI 05-AUG-2025
DEFINITION  A-kinase anchor protein 11 isoform X2 [Homo sapiens].
ACCESSION   XP_005266304
VERSION     XP_005266304.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266247.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1873
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1873
                     /product="A-kinase anchor protein 11 isoform X2"
                     /calculated_mol_wt=207421
     Region          <1655..1872
                     /region_name="AKAP_110"
                     /note="A-kinase anchor protein 110 kDa (AKAP 110);
                     cl14906"
                     /db_xref="CDD:449376"
     CDS             1..1873
                     /gene="AKAP11"
                     /gene_synonym="AKAP-11; AKAP220; PPP1R44; PRKA11"
                     /coded_by="XM_005266247.2:177..5798"
                     /db_xref="GeneID:11215"
                     /db_xref="HGNC:HGNC:369"
                     /db_xref="MIM:604696"
ORIGIN      
        1 matfrnnhmk tkasvrksfs edvfqsvksl lqsqkelcsv taedclqqde hanltevtfl
       61 gfneetdaah iqdlaavsle lpdilnslhf cslneneiic mkninkpldi ssdplnqshp
      121 sgmlcvmrvs ptsprlridf ifsllskyat girytldtfl hqkhqlettd eddddtnqsv
      181 ssieddfvta fehleeeets kpyndgmnit vlrsqcdaas qtvtghhlet hdlkilissg
      241 qqkslakpst ssvnvlghke lpsvktsvtt sisepwtqrs fyrssnasdk dsdlqktffs
      301 sspayssese csspspvifl deegyqkslk aklelpkipv mkddiedsds evseffdsfd
      361 qfdeleqtle tclfnkdpvi gkssqrkghk hgkscmnpqk fkfdrpalpa nvrkptprkp
      421 espygnlcda pdsprpvkas redsglfspi rssafsplgg ctpaecfcqt diggdrihen
      481 hdsvyytyed yaksiscevl gsvlrthhtn tlsninsikh genktvtfkh gnldqknksk
      541 nkslmikdsi qkfaadlvek sfgsafkdlq kgvssctnal yhlaikltss vlqmafdelr
      601 rqrafslker aisglanflv sealsnalkd lqyvkkqift ntvarfaadl aeelvfegim
      661 evcqfsypqt paspqcgsfd fedkvvklya kdlsesviqe afielsqvdv tfttkaavsv
      721 stdnikyvsa esvvpstqav tfspsfhnqa imvtkpvqey kkeytvqqal fctsgivtsi
      781 pvplagsall pyhisstacq akahlssdds nsngdsaqvh iatknreeka aclrniclps
      841 ehnpgnqndf kptnddiemq sssklpndpa iisnfsaavv htivnetles mtslevtkmv
      901 dertdyltks lkektppfsh cdqavlqcse assnkdmfad rlsksiikhs idksksvipn
      961 idknavykes lpvsgeesql tpekspkfpd sqnqlthcsl saakdcvpec kvsmvhgssl
     1021 etlpscpavt gqksdlkesa kdqplkkhnl nstslealsf gqenpfphsh tfsstaltcv
     1081 dglhvedkqk vrdrnvipdt ppstplvpsr assewdikkl tkklkgelak efapatppst
     1141 phnssvgsls eneqntieke efmlklmrsl seevessesg elpevdvkse hsgkkvqfae
     1201 alathilsla temaashldn kiiqepkvkn pclnvqsqrs vsptflnpsd enlktlcnfa
     1261 gdlaaevite aekiakvrnc mlfkqkknsc yadgdedykv eekldieavv hprevdpfil
     1321 slppsscmsg lmykypsces vtdeyaghli qilkqeggns elimdqyanr layrsvksgl
     1381 qeaakttkvq cnsrmfpvps sqvktnkell mfsnkehhqe adkkrqskrn egyfcknqtc
     1441 ertldpyrne vsqlysfsts lvhsitkdak eeltaslvgl pksltdsclf eksgyeedne
     1501 chvtpelpks lqpssqnhrf yhstgslngy gcgdnvvqav eqyakkvvdd tleltlgstv
     1561 frvsettksa drvtyaekls pltgqacryc dlkelhnctg nssqhffrqg slasskpasn
     1621 pkfssryqks rifhlsvpqi hvnldkkavl aekivaeaie kaerelssts laadsgigqe
     1681 gasfaeslat etmtaavtnv ghavssskei edfqstesvs sqqmnlsigd dstgswsnls
     1741 fedehqdess sfhhlsesdg pddkdeehed eveglgqdgk tllitnidme pctvdpqlri
     1801 ilqwliasea evaelyfhds ankefmllsk qlqekgwkvg dllqavlqyy evmekassee
     1861 rckslfdwll ena
//
LOCUS       XP_047286028            1873 aa            linear   PRI 05-AUG-2025
DEFINITION  A-kinase anchor protein 11 isoform X2 [Homo sapiens].
ACCESSION   XP_047286028
VERSION     XP_047286028.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430072.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1873
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1873
                     /product="A-kinase anchor protein 11 isoform X2"
                     /calculated_mol_wt=207421
     Region          <1655..1872
                     /region_name="AKAP_110"
                     /note="A-kinase anchor protein 110 kDa (AKAP 110);
                     cl14906"
                     /db_xref="CDD:449376"
     CDS             1..1873
                     /gene="AKAP11"
                     /gene_synonym="AKAP-11; AKAP220; PPP1R44; PRKA11"
                     /coded_by="XM_047430072.1:162..5783"
                     /db_xref="GeneID:11215"
                     /db_xref="HGNC:HGNC:369"
                     /db_xref="MIM:604696"
ORIGIN      
        1 matfrnnhmk tkasvrksfs edvfqsvksl lqsqkelcsv taedclqqde hanltevtfl
       61 gfneetdaah iqdlaavsle lpdilnslhf cslneneiic mkninkpldi ssdplnqshp
      121 sgmlcvmrvs ptsprlridf ifsllskyat girytldtfl hqkhqlettd eddddtnqsv
      181 ssieddfvta fehleeeets kpyndgmnit vlrsqcdaas qtvtghhlet hdlkilissg
      241 qqkslakpst ssvnvlghke lpsvktsvtt sisepwtqrs fyrssnasdk dsdlqktffs
      301 sspayssese csspspvifl deegyqkslk aklelpkipv mkddiedsds evseffdsfd
      361 qfdeleqtle tclfnkdpvi gkssqrkghk hgkscmnpqk fkfdrpalpa nvrkptprkp
      421 espygnlcda pdsprpvkas redsglfspi rssafsplgg ctpaecfcqt diggdrihen
      481 hdsvyytyed yaksiscevl gsvlrthhtn tlsninsikh genktvtfkh gnldqknksk
      541 nkslmikdsi qkfaadlvek sfgsafkdlq kgvssctnal yhlaikltss vlqmafdelr
      601 rqrafslker aisglanflv sealsnalkd lqyvkkqift ntvarfaadl aeelvfegim
      661 evcqfsypqt paspqcgsfd fedkvvklya kdlsesviqe afielsqvdv tfttkaavsv
      721 stdnikyvsa esvvpstqav tfspsfhnqa imvtkpvqey kkeytvqqal fctsgivtsi
      781 pvplagsall pyhisstacq akahlssdds nsngdsaqvh iatknreeka aclrniclps
      841 ehnpgnqndf kptnddiemq sssklpndpa iisnfsaavv htivnetles mtslevtkmv
      901 dertdyltks lkektppfsh cdqavlqcse assnkdmfad rlsksiikhs idksksvipn
      961 idknavykes lpvsgeesql tpekspkfpd sqnqlthcsl saakdcvpec kvsmvhgssl
     1021 etlpscpavt gqksdlkesa kdqplkkhnl nstslealsf gqenpfphsh tfsstaltcv
     1081 dglhvedkqk vrdrnvipdt ppstplvpsr assewdikkl tkklkgelak efapatppst
     1141 phnssvgsls eneqntieke efmlklmrsl seevessesg elpevdvkse hsgkkvqfae
     1201 alathilsla temaashldn kiiqepkvkn pclnvqsqrs vsptflnpsd enlktlcnfa
     1261 gdlaaevite aekiakvrnc mlfkqkknsc yadgdedykv eekldieavv hprevdpfil
     1321 slppsscmsg lmykypsces vtdeyaghli qilkqeggns elimdqyanr layrsvksgl
     1381 qeaakttkvq cnsrmfpvps sqvktnkell mfsnkehhqe adkkrqskrn egyfcknqtc
     1441 ertldpyrne vsqlysfsts lvhsitkdak eeltaslvgl pksltdsclf eksgyeedne
     1501 chvtpelpks lqpssqnhrf yhstgslngy gcgdnvvqav eqyakkvvdd tleltlgstv
     1561 frvsettksa drvtyaekls pltgqacryc dlkelhnctg nssqhffrqg slasskpasn
     1621 pkfssryqks rifhlsvpqi hvnldkkavl aekivaeaie kaerelssts laadsgigqe
     1681 gasfaeslat etmtaavtnv ghavssskei edfqstesvs sqqmnlsigd dstgswsnls
     1741 fedehqdess sfhhlsesdg pddkdeehed eveglgqdgk tllitnidme pctvdpqlri
     1801 ilqwliasea evaelyfhds ankefmllsk qlqekgwkvg dllqavlqyy evmekassee
     1861 rckslfdwll ena
//
LOCUS       XP_047286029            1873 aa            linear   PRI 05-AUG-2025
DEFINITION  A-kinase anchor protein 11 isoform X2 [Homo sapiens].
ACCESSION   XP_047286029
VERSION     XP_047286029.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430073.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1873
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1873
                     /product="A-kinase anchor protein 11 isoform X2"
                     /calculated_mol_wt=207421
     Region          <1655..1872
                     /region_name="AKAP_110"
                     /note="A-kinase anchor protein 110 kDa (AKAP 110);
                     cl14906"
                     /db_xref="CDD:449376"
     CDS             1..1873
                     /gene="AKAP11"
                     /gene_synonym="AKAP-11; AKAP220; PPP1R44; PRKA11"
                     /coded_by="XM_047430073.1:388..6009"
                     /db_xref="GeneID:11215"
                     /db_xref="HGNC:HGNC:369"
                     /db_xref="MIM:604696"
ORIGIN      
        1 matfrnnhmk tkasvrksfs edvfqsvksl lqsqkelcsv taedclqqde hanltevtfl
       61 gfneetdaah iqdlaavsle lpdilnslhf cslneneiic mkninkpldi ssdplnqshp
      121 sgmlcvmrvs ptsprlridf ifsllskyat girytldtfl hqkhqlettd eddddtnqsv
      181 ssieddfvta fehleeeets kpyndgmnit vlrsqcdaas qtvtghhlet hdlkilissg
      241 qqkslakpst ssvnvlghke lpsvktsvtt sisepwtqrs fyrssnasdk dsdlqktffs
      301 sspayssese csspspvifl deegyqkslk aklelpkipv mkddiedsds evseffdsfd
      361 qfdeleqtle tclfnkdpvi gkssqrkghk hgkscmnpqk fkfdrpalpa nvrkptprkp
      421 espygnlcda pdsprpvkas redsglfspi rssafsplgg ctpaecfcqt diggdrihen
      481 hdsvyytyed yaksiscevl gsvlrthhtn tlsninsikh genktvtfkh gnldqknksk
      541 nkslmikdsi qkfaadlvek sfgsafkdlq kgvssctnal yhlaikltss vlqmafdelr
      601 rqrafslker aisglanflv sealsnalkd lqyvkkqift ntvarfaadl aeelvfegim
      661 evcqfsypqt paspqcgsfd fedkvvklya kdlsesviqe afielsqvdv tfttkaavsv
      721 stdnikyvsa esvvpstqav tfspsfhnqa imvtkpvqey kkeytvqqal fctsgivtsi
      781 pvplagsall pyhisstacq akahlssdds nsngdsaqvh iatknreeka aclrniclps
      841 ehnpgnqndf kptnddiemq sssklpndpa iisnfsaavv htivnetles mtslevtkmv
      901 dertdyltks lkektppfsh cdqavlqcse assnkdmfad rlsksiikhs idksksvipn
      961 idknavykes lpvsgeesql tpekspkfpd sqnqlthcsl saakdcvpec kvsmvhgssl
     1021 etlpscpavt gqksdlkesa kdqplkkhnl nstslealsf gqenpfphsh tfsstaltcv
     1081 dglhvedkqk vrdrnvipdt ppstplvpsr assewdikkl tkklkgelak efapatppst
     1141 phnssvgsls eneqntieke efmlklmrsl seevessesg elpevdvkse hsgkkvqfae
     1201 alathilsla temaashldn kiiqepkvkn pclnvqsqrs vsptflnpsd enlktlcnfa
     1261 gdlaaevite aekiakvrnc mlfkqkknsc yadgdedykv eekldieavv hprevdpfil
     1321 slppsscmsg lmykypsces vtdeyaghli qilkqeggns elimdqyanr layrsvksgl
     1381 qeaakttkvq cnsrmfpvps sqvktnkell mfsnkehhqe adkkrqskrn egyfcknqtc
     1441 ertldpyrne vsqlysfsts lvhsitkdak eeltaslvgl pksltdsclf eksgyeedne
     1501 chvtpelpks lqpssqnhrf yhstgslngy gcgdnvvqav eqyakkvvdd tleltlgstv
     1561 frvsettksa drvtyaekls pltgqacryc dlkelhnctg nssqhffrqg slasskpasn
     1621 pkfssryqks rifhlsvpqi hvnldkkavl aekivaeaie kaerelssts laadsgigqe
     1681 gasfaeslat etmtaavtnv ghavssskei edfqstesvs sqqmnlsigd dstgswsnls
     1741 fedehqdess sfhhlsesdg pddkdeehed eveglgqdgk tllitnidme pctvdpqlri
     1801 ilqwliasea evaelyfhds ankefmllsk qlqekgwkvg dllqavlqyy evmekassee
     1861 rckslfdwll ena
//
LOCUS       XP_047286030            1873 aa            linear   PRI 05-AUG-2025
DEFINITION  A-kinase anchor protein 11 isoform X2 [Homo sapiens].
ACCESSION   XP_047286030
VERSION     XP_047286030.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430074.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1873
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1873
                     /product="A-kinase anchor protein 11 isoform X2"
                     /calculated_mol_wt=207421
     Region          <1655..1872
                     /region_name="AKAP_110"
                     /note="A-kinase anchor protein 110 kDa (AKAP 110);
                     cl14906"
                     /db_xref="CDD:449376"
     CDS             1..1873
                     /gene="AKAP11"
                     /gene_synonym="AKAP-11; AKAP220; PPP1R44; PRKA11"
                     /coded_by="XM_047430074.1:127..5748"
                     /db_xref="GeneID:11215"
                     /db_xref="HGNC:HGNC:369"
                     /db_xref="MIM:604696"
ORIGIN      
        1 matfrnnhmk tkasvrksfs edvfqsvksl lqsqkelcsv taedclqqde hanltevtfl
       61 gfneetdaah iqdlaavsle lpdilnslhf cslneneiic mkninkpldi ssdplnqshp
      121 sgmlcvmrvs ptsprlridf ifsllskyat girytldtfl hqkhqlettd eddddtnqsv
      181 ssieddfvta fehleeeets kpyndgmnit vlrsqcdaas qtvtghhlet hdlkilissg
      241 qqkslakpst ssvnvlghke lpsvktsvtt sisepwtqrs fyrssnasdk dsdlqktffs
      301 sspayssese csspspvifl deegyqkslk aklelpkipv mkddiedsds evseffdsfd
      361 qfdeleqtle tclfnkdpvi gkssqrkghk hgkscmnpqk fkfdrpalpa nvrkptprkp
      421 espygnlcda pdsprpvkas redsglfspi rssafsplgg ctpaecfcqt diggdrihen
      481 hdsvyytyed yaksiscevl gsvlrthhtn tlsninsikh genktvtfkh gnldqknksk
      541 nkslmikdsi qkfaadlvek sfgsafkdlq kgvssctnal yhlaikltss vlqmafdelr
      601 rqrafslker aisglanflv sealsnalkd lqyvkkqift ntvarfaadl aeelvfegim
      661 evcqfsypqt paspqcgsfd fedkvvklya kdlsesviqe afielsqvdv tfttkaavsv
      721 stdnikyvsa esvvpstqav tfspsfhnqa imvtkpvqey kkeytvqqal fctsgivtsi
      781 pvplagsall pyhisstacq akahlssdds nsngdsaqvh iatknreeka aclrniclps
      841 ehnpgnqndf kptnddiemq sssklpndpa iisnfsaavv htivnetles mtslevtkmv
      901 dertdyltks lkektppfsh cdqavlqcse assnkdmfad rlsksiikhs idksksvipn
      961 idknavykes lpvsgeesql tpekspkfpd sqnqlthcsl saakdcvpec kvsmvhgssl
     1021 etlpscpavt gqksdlkesa kdqplkkhnl nstslealsf gqenpfphsh tfsstaltcv
     1081 dglhvedkqk vrdrnvipdt ppstplvpsr assewdikkl tkklkgelak efapatppst
     1141 phnssvgsls eneqntieke efmlklmrsl seevessesg elpevdvkse hsgkkvqfae
     1201 alathilsla temaashldn kiiqepkvkn pclnvqsqrs vsptflnpsd enlktlcnfa
     1261 gdlaaevite aekiakvrnc mlfkqkknsc yadgdedykv eekldieavv hprevdpfil
     1321 slppsscmsg lmykypsces vtdeyaghli qilkqeggns elimdqyanr layrsvksgl
     1381 qeaakttkvq cnsrmfpvps sqvktnkell mfsnkehhqe adkkrqskrn egyfcknqtc
     1441 ertldpyrne vsqlysfsts lvhsitkdak eeltaslvgl pksltdsclf eksgyeedne
     1501 chvtpelpks lqpssqnhrf yhstgslngy gcgdnvvqav eqyakkvvdd tleltlgstv
     1561 frvsettksa drvtyaekls pltgqacryc dlkelhnctg nssqhffrqg slasskpasn
     1621 pkfssryqks rifhlsvpqi hvnldkkavl aekivaeaie kaerelssts laadsgigqe
     1681 gasfaeslat etmtaavtnv ghavssskei edfqstesvs sqqmnlsigd dstgswsnls
     1741 fedehqdess sfhhlsesdg pddkdeehed eveglgqdgk tllitnidme pctvdpqlri
     1801 ilqwliasea evaelyfhds ankefmllsk qlqekgwkvg dllqavlqyy evmekassee
     1861 rckslfdwll ena
//
LOCUS       XP_047286031            1873 aa            linear   PRI 05-AUG-2025
DEFINITION  A-kinase anchor protein 11 isoform X2 [Homo sapiens].
ACCESSION   XP_047286031
VERSION     XP_047286031.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430075.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1873
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1873
                     /product="A-kinase anchor protein 11 isoform X2"
                     /calculated_mol_wt=207421
     Region          <1655..1872
                     /region_name="AKAP_110"
                     /note="A-kinase anchor protein 110 kDa (AKAP 110);
                     cl14906"
                     /db_xref="CDD:449376"
     CDS             1..1873
                     /gene="AKAP11"
                     /gene_synonym="AKAP-11; AKAP220; PPP1R44; PRKA11"
                     /coded_by="XM_047430075.1:338..5959"
                     /db_xref="GeneID:11215"
                     /db_xref="HGNC:HGNC:369"
                     /db_xref="MIM:604696"
ORIGIN      
        1 matfrnnhmk tkasvrksfs edvfqsvksl lqsqkelcsv taedclqqde hanltevtfl
       61 gfneetdaah iqdlaavsle lpdilnslhf cslneneiic mkninkpldi ssdplnqshp
      121 sgmlcvmrvs ptsprlridf ifsllskyat girytldtfl hqkhqlettd eddddtnqsv
      181 ssieddfvta fehleeeets kpyndgmnit vlrsqcdaas qtvtghhlet hdlkilissg
      241 qqkslakpst ssvnvlghke lpsvktsvtt sisepwtqrs fyrssnasdk dsdlqktffs
      301 sspayssese csspspvifl deegyqkslk aklelpkipv mkddiedsds evseffdsfd
      361 qfdeleqtle tclfnkdpvi gkssqrkghk hgkscmnpqk fkfdrpalpa nvrkptprkp
      421 espygnlcda pdsprpvkas redsglfspi rssafsplgg ctpaecfcqt diggdrihen
      481 hdsvyytyed yaksiscevl gsvlrthhtn tlsninsikh genktvtfkh gnldqknksk
      541 nkslmikdsi qkfaadlvek sfgsafkdlq kgvssctnal yhlaikltss vlqmafdelr
      601 rqrafslker aisglanflv sealsnalkd lqyvkkqift ntvarfaadl aeelvfegim
      661 evcqfsypqt paspqcgsfd fedkvvklya kdlsesviqe afielsqvdv tfttkaavsv
      721 stdnikyvsa esvvpstqav tfspsfhnqa imvtkpvqey kkeytvqqal fctsgivtsi
      781 pvplagsall pyhisstacq akahlssdds nsngdsaqvh iatknreeka aclrniclps
      841 ehnpgnqndf kptnddiemq sssklpndpa iisnfsaavv htivnetles mtslevtkmv
      901 dertdyltks lkektppfsh cdqavlqcse assnkdmfad rlsksiikhs idksksvipn
      961 idknavykes lpvsgeesql tpekspkfpd sqnqlthcsl saakdcvpec kvsmvhgssl
     1021 etlpscpavt gqksdlkesa kdqplkkhnl nstslealsf gqenpfphsh tfsstaltcv
     1081 dglhvedkqk vrdrnvipdt ppstplvpsr assewdikkl tkklkgelak efapatppst
     1141 phnssvgsls eneqntieke efmlklmrsl seevessesg elpevdvkse hsgkkvqfae
     1201 alathilsla temaashldn kiiqepkvkn pclnvqsqrs vsptflnpsd enlktlcnfa
     1261 gdlaaevite aekiakvrnc mlfkqkknsc yadgdedykv eekldieavv hprevdpfil
     1321 slppsscmsg lmykypsces vtdeyaghli qilkqeggns elimdqyanr layrsvksgl
     1381 qeaakttkvq cnsrmfpvps sqvktnkell mfsnkehhqe adkkrqskrn egyfcknqtc
     1441 ertldpyrne vsqlysfsts lvhsitkdak eeltaslvgl pksltdsclf eksgyeedne
     1501 chvtpelpks lqpssqnhrf yhstgslngy gcgdnvvqav eqyakkvvdd tleltlgstv
     1561 frvsettksa drvtyaekls pltgqacryc dlkelhnctg nssqhffrqg slasskpasn
     1621 pkfssryqks rifhlsvpqi hvnldkkavl aekivaeaie kaerelssts laadsgigqe
     1681 gasfaeslat etmtaavtnv ghavssskei edfqstesvs sqqmnlsigd dstgswsnls
     1741 fedehqdess sfhhlsesdg pddkdeehed eveglgqdgk tllitnidme pctvdpqlri
     1801 ilqwliasea evaelyfhds ankefmllsk qlqekgwkvg dllqavlqyy evmekassee
     1861 rckslfdwll ena
//
LOCUS       XP_005266305            1856 aa            linear   PRI 05-AUG-2025
DEFINITION  A-kinase anchor protein 11 isoform X3 [Homo sapiens].
ACCESSION   XP_005266305
VERSION     XP_005266305.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266248.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1856
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1856
                     /product="A-kinase anchor protein 11 isoform X3"
                     /calculated_mol_wt=205404
     Region          <1759..1855
                     /region_name="AKAP_110"
                     /note="A-kinase anchor protein 110 kDa (AKAP 110);
                     cl14906"
                     /db_xref="CDD:449376"
     CDS             1..1856
                     /gene="AKAP11"
                     /gene_synonym="AKAP-11; AKAP220; PPP1R44; PRKA11"
                     /coded_by="XM_005266248.4:177..5747"
                     /db_xref="GeneID:11215"
                     /db_xref="HGNC:HGNC:369"
                     /db_xref="MIM:604696"
ORIGIN      
        1 matfrnnhmk tkasvrksfs edvfqsvksl lqsqkelcsv taedclqqde hanltevtfl
       61 gfneetdaah iqshpsgmlc vmrvsptspr lridfifsll skyatgiryt ldtflhqkhq
      121 lettdedddd tnqsvssied dfvtafehle eeetskpynd gmnitvlrsq cdaasqtvtg
      181 hhlethdlki lissgqqksl akpstssvnv lghkelpsvk tsvttsisep wtqrsfyrss
      241 nasdkdsdlq ktffssspay ssesecssps pvifldeegy qkslkaklel pkipvmkddi
      301 edsdsevsef fdsfdqfdel eqtletclfn kdpvigkssq rkghkhgksc mnpqkfkfdr
      361 palpanvrkp tprkpespyg nlcdapdspr pvkasredsg lfspirssaf splggctpae
      421 cfcqtdiggd rihenhdsvy ytyedyaksi scevlgsvlr thhtntlsni nsikhgenkt
      481 vtfkhgnldq knksknkslm ikdsiqkfaa dlveksfgsa fkdlqkgvss ctnalyhlai
      541 kltssvlqma fdelrrqraf slkeraisgl anflvseals nalkdlqyvk kqiftntvar
      601 faadlaeelv fegimevcqf sypqtpaspq cgsfdfedkv vklyakdlse sviqeafiel
      661 sqvdvtfttk aavsvstdni kyvsaesvvp stqavtfsps fhnqaimvtk pvqeykkeyt
      721 vqqalfctsg ivtsipvpla gsallpyhis stacqakahl ssddsnsngd saqvhiatkn
      781 reekaaclrn iclpsehnpg nqndfkptnd diemqssskl pndpaiisnf saavvhtivn
      841 etlesmtsle vtkmvdertd yltkslkekt ppfshcdqav lqcseassnk dmfadrlsks
      901 iikhsidksk svipnidkna vykeslpvsg eesqltpeks pkfpdsqnql thcslsaakd
      961 cvpeckvsmv hgssletlps cpavtgqksd lkesakdqpl kkhnlnstsl ealsfgqenp
     1021 fphshtfsst altcvdglhv edkqkvrdrn vipdtppstp lvpsrassew dikkltkklk
     1081 gelakefapa tppstphnss vgslseneqn tiekeefmlk lmrslseeve ssesgelpev
     1141 dvksehsgkk vqfaealath ilslatemaa shldnkiiqe pkvknpclnv qsqrsvsptf
     1201 lnpsdenlkt lcnfagdlaa eviteaekia kvrncmlfkq kknscyadgd edykveekld
     1261 ieavvhprev dpfilslpps scmsglmyky pscesvtdey aghliqilkq eggnselimd
     1321 qyanrlayrs vksglqeaak ttkvqcnsrm fpvpssqvkt nkellmfsnk ehhqeadkkr
     1381 qskrnegyfc knqtcertld pyrnevsqly sfstslvhsi tkdakeelta slvglpkslt
     1441 dsclfeksgy eednechvtp elpkslqpss qnhrfyhstg slngygcgdn vvqaveqyak
     1501 kvvddtlelt lgstvfrvse ttksadrvty aeklspltgq acrycdlkel hnctgnssqh
     1561 ffrqgslass kpasnpkfss ryqksrifhl svpqihvnld kkavlaekiv aeaiekaere
     1621 lsstslaads gigqegasfa eslatetmta avtnvghavs sskeiedfqs tesvssqqmn
     1681 lsigddstgs wsnlsfedeh qdesssfhhl sesngnsssw sslglegdly ednlsfptsd
     1741 sdgpddkdee hedeveglgq dgktllitni dmepctvdpq lriilqwlia seaevaelyf
     1801 hdsankefml lskqlqekgw kvgdllqavl qyyevmekas seerckslfd wllena
//
LOCUS       XP_047286032            1856 aa            linear   PRI 05-AUG-2025
DEFINITION  A-kinase anchor protein 11 isoform X3 [Homo sapiens].
ACCESSION   XP_047286032
VERSION     XP_047286032.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430076.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1856
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1856
                     /product="A-kinase anchor protein 11 isoform X3"
                     /calculated_mol_wt=205404
     Region          <1759..1855
                     /region_name="AKAP_110"
                     /note="A-kinase anchor protein 110 kDa (AKAP 110);
                     cl14906"
                     /db_xref="CDD:449376"
     CDS             1..1856
                     /gene="AKAP11"
                     /gene_synonym="AKAP-11; AKAP220; PPP1R44; PRKA11"
                     /coded_by="XM_047430076.1:162..5732"
                     /db_xref="GeneID:11215"
                     /db_xref="HGNC:HGNC:369"
                     /db_xref="MIM:604696"
ORIGIN      
        1 matfrnnhmk tkasvrksfs edvfqsvksl lqsqkelcsv taedclqqde hanltevtfl
       61 gfneetdaah iqshpsgmlc vmrvsptspr lridfifsll skyatgiryt ldtflhqkhq
      121 lettdedddd tnqsvssied dfvtafehle eeetskpynd gmnitvlrsq cdaasqtvtg
      181 hhlethdlki lissgqqksl akpstssvnv lghkelpsvk tsvttsisep wtqrsfyrss
      241 nasdkdsdlq ktffssspay ssesecssps pvifldeegy qkslkaklel pkipvmkddi
      301 edsdsevsef fdsfdqfdel eqtletclfn kdpvigkssq rkghkhgksc mnpqkfkfdr
      361 palpanvrkp tprkpespyg nlcdapdspr pvkasredsg lfspirssaf splggctpae
      421 cfcqtdiggd rihenhdsvy ytyedyaksi scevlgsvlr thhtntlsni nsikhgenkt
      481 vtfkhgnldq knksknkslm ikdsiqkfaa dlveksfgsa fkdlqkgvss ctnalyhlai
      541 kltssvlqma fdelrrqraf slkeraisgl anflvseals nalkdlqyvk kqiftntvar
      601 faadlaeelv fegimevcqf sypqtpaspq cgsfdfedkv vklyakdlse sviqeafiel
      661 sqvdvtfttk aavsvstdni kyvsaesvvp stqavtfsps fhnqaimvtk pvqeykkeyt
      721 vqqalfctsg ivtsipvpla gsallpyhis stacqakahl ssddsnsngd saqvhiatkn
      781 reekaaclrn iclpsehnpg nqndfkptnd diemqssskl pndpaiisnf saavvhtivn
      841 etlesmtsle vtkmvdertd yltkslkekt ppfshcdqav lqcseassnk dmfadrlsks
      901 iikhsidksk svipnidkna vykeslpvsg eesqltpeks pkfpdsqnql thcslsaakd
      961 cvpeckvsmv hgssletlps cpavtgqksd lkesakdqpl kkhnlnstsl ealsfgqenp
     1021 fphshtfsst altcvdglhv edkqkvrdrn vipdtppstp lvpsrassew dikkltkklk
     1081 gelakefapa tppstphnss vgslseneqn tiekeefmlk lmrslseeve ssesgelpev
     1141 dvksehsgkk vqfaealath ilslatemaa shldnkiiqe pkvknpclnv qsqrsvsptf
     1201 lnpsdenlkt lcnfagdlaa eviteaekia kvrncmlfkq kknscyadgd edykveekld
     1261 ieavvhprev dpfilslpps scmsglmyky pscesvtdey aghliqilkq eggnselimd
     1321 qyanrlayrs vksglqeaak ttkvqcnsrm fpvpssqvkt nkellmfsnk ehhqeadkkr
     1381 qskrnegyfc knqtcertld pyrnevsqly sfstslvhsi tkdakeelta slvglpkslt
     1441 dsclfeksgy eednechvtp elpkslqpss qnhrfyhstg slngygcgdn vvqaveqyak
     1501 kvvddtlelt lgstvfrvse ttksadrvty aeklspltgq acrycdlkel hnctgnssqh
     1561 ffrqgslass kpasnpkfss ryqksrifhl svpqihvnld kkavlaekiv aeaiekaere
     1621 lsstslaads gigqegasfa eslatetmta avtnvghavs sskeiedfqs tesvssqqmn
     1681 lsigddstgs wsnlsfedeh qdesssfhhl sesngnsssw sslglegdly ednlsfptsd
     1741 sdgpddkdee hedeveglgq dgktllitni dmepctvdpq lriilqwlia seaevaelyf
     1801 hdsankefml lskqlqekgw kvgdllqavl qyyevmekas seerckslfd wllena
//
LOCUS       XP_016875871            1856 aa            linear   PRI 05-AUG-2025
DEFINITION  A-kinase anchor protein 11 isoform X3 [Homo sapiens].
ACCESSION   XP_016875871
VERSION     XP_016875871.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020382.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1856
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1856
                     /product="A-kinase anchor protein 11 isoform X3"
                     /calculated_mol_wt=205404
     Region          <1759..1855
                     /region_name="AKAP_110"
                     /note="A-kinase anchor protein 110 kDa (AKAP 110);
                     cl14906"
                     /db_xref="CDD:449376"
     CDS             1..1856
                     /gene="AKAP11"
                     /gene_synonym="AKAP-11; AKAP220; PPP1R44; PRKA11"
                     /coded_by="XM_017020382.2:127..5697"
                     /db_xref="GeneID:11215"
                     /db_xref="HGNC:HGNC:369"
                     /db_xref="MIM:604696"
ORIGIN      
        1 matfrnnhmk tkasvrksfs edvfqsvksl lqsqkelcsv taedclqqde hanltevtfl
       61 gfneetdaah iqshpsgmlc vmrvsptspr lridfifsll skyatgiryt ldtflhqkhq
      121 lettdedddd tnqsvssied dfvtafehle eeetskpynd gmnitvlrsq cdaasqtvtg
      181 hhlethdlki lissgqqksl akpstssvnv lghkelpsvk tsvttsisep wtqrsfyrss
      241 nasdkdsdlq ktffssspay ssesecssps pvifldeegy qkslkaklel pkipvmkddi
      301 edsdsevsef fdsfdqfdel eqtletclfn kdpvigkssq rkghkhgksc mnpqkfkfdr
      361 palpanvrkp tprkpespyg nlcdapdspr pvkasredsg lfspirssaf splggctpae
      421 cfcqtdiggd rihenhdsvy ytyedyaksi scevlgsvlr thhtntlsni nsikhgenkt
      481 vtfkhgnldq knksknkslm ikdsiqkfaa dlveksfgsa fkdlqkgvss ctnalyhlai
      541 kltssvlqma fdelrrqraf slkeraisgl anflvseals nalkdlqyvk kqiftntvar
      601 faadlaeelv fegimevcqf sypqtpaspq cgsfdfedkv vklyakdlse sviqeafiel
      661 sqvdvtfttk aavsvstdni kyvsaesvvp stqavtfsps fhnqaimvtk pvqeykkeyt
      721 vqqalfctsg ivtsipvpla gsallpyhis stacqakahl ssddsnsngd saqvhiatkn
      781 reekaaclrn iclpsehnpg nqndfkptnd diemqssskl pndpaiisnf saavvhtivn
      841 etlesmtsle vtkmvdertd yltkslkekt ppfshcdqav lqcseassnk dmfadrlsks
      901 iikhsidksk svipnidkna vykeslpvsg eesqltpeks pkfpdsqnql thcslsaakd
      961 cvpeckvsmv hgssletlps cpavtgqksd lkesakdqpl kkhnlnstsl ealsfgqenp
     1021 fphshtfsst altcvdglhv edkqkvrdrn vipdtppstp lvpsrassew dikkltkklk
     1081 gelakefapa tppstphnss vgslseneqn tiekeefmlk lmrslseeve ssesgelpev
     1141 dvksehsgkk vqfaealath ilslatemaa shldnkiiqe pkvknpclnv qsqrsvsptf
     1201 lnpsdenlkt lcnfagdlaa eviteaekia kvrncmlfkq kknscyadgd edykveekld
     1261 ieavvhprev dpfilslpps scmsglmyky pscesvtdey aghliqilkq eggnselimd
     1321 qyanrlayrs vksglqeaak ttkvqcnsrm fpvpssqvkt nkellmfsnk ehhqeadkkr
     1381 qskrnegyfc knqtcertld pyrnevsqly sfstslvhsi tkdakeelta slvglpkslt
     1441 dsclfeksgy eednechvtp elpkslqpss qnhrfyhstg slngygcgdn vvqaveqyak
     1501 kvvddtlelt lgstvfrvse ttksadrvty aeklspltgq acrycdlkel hnctgnssqh
     1561 ffrqgslass kpasnpkfss ryqksrifhl svpqihvnld kkavlaekiv aeaiekaere
     1621 lsstslaads gigqegasfa eslatetmta avtnvghavs sskeiedfqs tesvssqqmn
     1681 lsigddstgs wsnlsfedeh qdesssfhhl sesngnsssw sslglegdly ednlsfptsd
     1741 sdgpddkdee hedeveglgq dgktllitni dmepctvdpq lriilqwlia seaevaelyf
     1801 hdsankefml lskqlqekgw kvgdllqavl qyyevmekas seerckslfd wllena
//
LOCUS       XP_016875872            1856 aa            linear   PRI 05-AUG-2025
DEFINITION  A-kinase anchor protein 11 isoform X3 [Homo sapiens].
ACCESSION   XP_016875872
VERSION     XP_016875872.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020383.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1856
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1856
                     /product="A-kinase anchor protein 11 isoform X3"
                     /calculated_mol_wt=205404
     Region          <1759..1855
                     /region_name="AKAP_110"
                     /note="A-kinase anchor protein 110 kDa (AKAP 110);
                     cl14906"
                     /db_xref="CDD:449376"
     CDS             1..1856
                     /gene="AKAP11"
                     /gene_synonym="AKAP-11; AKAP220; PPP1R44; PRKA11"
                     /coded_by="XM_017020383.2:338..5908"
                     /db_xref="GeneID:11215"
                     /db_xref="HGNC:HGNC:369"
                     /db_xref="MIM:604696"
ORIGIN      
        1 matfrnnhmk tkasvrksfs edvfqsvksl lqsqkelcsv taedclqqde hanltevtfl
       61 gfneetdaah iqshpsgmlc vmrvsptspr lridfifsll skyatgiryt ldtflhqkhq
      121 lettdedddd tnqsvssied dfvtafehle eeetskpynd gmnitvlrsq cdaasqtvtg
      181 hhlethdlki lissgqqksl akpstssvnv lghkelpsvk tsvttsisep wtqrsfyrss
      241 nasdkdsdlq ktffssspay ssesecssps pvifldeegy qkslkaklel pkipvmkddi
      301 edsdsevsef fdsfdqfdel eqtletclfn kdpvigkssq rkghkhgksc mnpqkfkfdr
      361 palpanvrkp tprkpespyg nlcdapdspr pvkasredsg lfspirssaf splggctpae
      421 cfcqtdiggd rihenhdsvy ytyedyaksi scevlgsvlr thhtntlsni nsikhgenkt
      481 vtfkhgnldq knksknkslm ikdsiqkfaa dlveksfgsa fkdlqkgvss ctnalyhlai
      541 kltssvlqma fdelrrqraf slkeraisgl anflvseals nalkdlqyvk kqiftntvar
      601 faadlaeelv fegimevcqf sypqtpaspq cgsfdfedkv vklyakdlse sviqeafiel
      661 sqvdvtfttk aavsvstdni kyvsaesvvp stqavtfsps fhnqaimvtk pvqeykkeyt
      721 vqqalfctsg ivtsipvpla gsallpyhis stacqakahl ssddsnsngd saqvhiatkn
      781 reekaaclrn iclpsehnpg nqndfkptnd diemqssskl pndpaiisnf saavvhtivn
      841 etlesmtsle vtkmvdertd yltkslkekt ppfshcdqav lqcseassnk dmfadrlsks
      901 iikhsidksk svipnidkna vykeslpvsg eesqltpeks pkfpdsqnql thcslsaakd
      961 cvpeckvsmv hgssletlps cpavtgqksd lkesakdqpl kkhnlnstsl ealsfgqenp
     1021 fphshtfsst altcvdglhv edkqkvrdrn vipdtppstp lvpsrassew dikkltkklk
     1081 gelakefapa tppstphnss vgslseneqn tiekeefmlk lmrslseeve ssesgelpev
     1141 dvksehsgkk vqfaealath ilslatemaa shldnkiiqe pkvknpclnv qsqrsvsptf
     1201 lnpsdenlkt lcnfagdlaa eviteaekia kvrncmlfkq kknscyadgd edykveekld
     1261 ieavvhprev dpfilslpps scmsglmyky pscesvtdey aghliqilkq eggnselimd
     1321 qyanrlayrs vksglqeaak ttkvqcnsrm fpvpssqvkt nkellmfsnk ehhqeadkkr
     1381 qskrnegyfc knqtcertld pyrnevsqly sfstslvhsi tkdakeelta slvglpkslt
     1441 dsclfeksgy eednechvtp elpkslqpss qnhrfyhstg slngygcgdn vvqaveqyak
     1501 kvvddtlelt lgstvfrvse ttksadrvty aeklspltgq acrycdlkel hnctgnssqh
     1561 ffrqgslass kpasnpkfss ryqksrifhl svpqihvnld kkavlaekiv aeaiekaere
     1621 lsstslaads gigqegasfa eslatetmta avtnvghavs sskeiedfqs tesvssqqmn
     1681 lsigddstgs wsnlsfedeh qdesssfhhl sesngnsssw sslglegdly ednlsfptsd
     1741 sdgpddkdee hedeveglgq dgktllitni dmepctvdpq lriilqwlia seaevaelyf
     1801 hdsankefml lskqlqekgw kvgdllqavl qyyevmekas seerckslfd wllena
//
LOCUS       XP_047286033            1856 aa            linear   PRI 05-AUG-2025
DEFINITION  A-kinase anchor protein 11 isoform X3 [Homo sapiens].
ACCESSION   XP_047286033
VERSION     XP_047286033.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430077.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1856
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1856
                     /product="A-kinase anchor protein 11 isoform X3"
                     /calculated_mol_wt=205404
     Region          <1759..1855
                     /region_name="AKAP_110"
                     /note="A-kinase anchor protein 110 kDa (AKAP 110);
                     cl14906"
                     /db_xref="CDD:449376"
     CDS             1..1856
                     /gene="AKAP11"
                     /gene_synonym="AKAP-11; AKAP220; PPP1R44; PRKA11"
                     /coded_by="XM_047430077.1:388..5958"
                     /db_xref="GeneID:11215"
                     /db_xref="HGNC:HGNC:369"
                     /db_xref="MIM:604696"
ORIGIN      
        1 matfrnnhmk tkasvrksfs edvfqsvksl lqsqkelcsv taedclqqde hanltevtfl
       61 gfneetdaah iqshpsgmlc vmrvsptspr lridfifsll skyatgiryt ldtflhqkhq
      121 lettdedddd tnqsvssied dfvtafehle eeetskpynd gmnitvlrsq cdaasqtvtg
      181 hhlethdlki lissgqqksl akpstssvnv lghkelpsvk tsvttsisep wtqrsfyrss
      241 nasdkdsdlq ktffssspay ssesecssps pvifldeegy qkslkaklel pkipvmkddi
      301 edsdsevsef fdsfdqfdel eqtletclfn kdpvigkssq rkghkhgksc mnpqkfkfdr
      361 palpanvrkp tprkpespyg nlcdapdspr pvkasredsg lfspirssaf splggctpae
      421 cfcqtdiggd rihenhdsvy ytyedyaksi scevlgsvlr thhtntlsni nsikhgenkt
      481 vtfkhgnldq knksknkslm ikdsiqkfaa dlveksfgsa fkdlqkgvss ctnalyhlai
      541 kltssvlqma fdelrrqraf slkeraisgl anflvseals nalkdlqyvk kqiftntvar
      601 faadlaeelv fegimevcqf sypqtpaspq cgsfdfedkv vklyakdlse sviqeafiel
      661 sqvdvtfttk aavsvstdni kyvsaesvvp stqavtfsps fhnqaimvtk pvqeykkeyt
      721 vqqalfctsg ivtsipvpla gsallpyhis stacqakahl ssddsnsngd saqvhiatkn
      781 reekaaclrn iclpsehnpg nqndfkptnd diemqssskl pndpaiisnf saavvhtivn
      841 etlesmtsle vtkmvdertd yltkslkekt ppfshcdqav lqcseassnk dmfadrlsks
      901 iikhsidksk svipnidkna vykeslpvsg eesqltpeks pkfpdsqnql thcslsaakd
      961 cvpeckvsmv hgssletlps cpavtgqksd lkesakdqpl kkhnlnstsl ealsfgqenp
     1021 fphshtfsst altcvdglhv edkqkvrdrn vipdtppstp lvpsrassew dikkltkklk
     1081 gelakefapa tppstphnss vgslseneqn tiekeefmlk lmrslseeve ssesgelpev
     1141 dvksehsgkk vqfaealath ilslatemaa shldnkiiqe pkvknpclnv qsqrsvsptf
     1201 lnpsdenlkt lcnfagdlaa eviteaekia kvrncmlfkq kknscyadgd edykveekld
     1261 ieavvhprev dpfilslpps scmsglmyky pscesvtdey aghliqilkq eggnselimd
     1321 qyanrlayrs vksglqeaak ttkvqcnsrm fpvpssqvkt nkellmfsnk ehhqeadkkr
     1381 qskrnegyfc knqtcertld pyrnevsqly sfstslvhsi tkdakeelta slvglpkslt
     1441 dsclfeksgy eednechvtp elpkslqpss qnhrfyhstg slngygcgdn vvqaveqyak
     1501 kvvddtlelt lgstvfrvse ttksadrvty aeklspltgq acrycdlkel hnctgnssqh
     1561 ffrqgslass kpasnpkfss ryqksrifhl svpqihvnld kkavlaekiv aeaiekaere
     1621 lsstslaads gigqegasfa eslatetmta avtnvghavs sskeiedfqs tesvssqqmn
     1681 lsigddstgs wsnlsfedeh qdesssfhhl sesngnsssw sslglegdly ednlsfptsd
     1741 sdgpddkdee hedeveglgq dgktllitni dmepctvdpq lriilqwlia seaevaelyf
     1801 hdsankefml lskqlqekgw kvgdllqavl qyyevmekas seerckslfd wllena
//
LOCUS       XP_047286034            1828 aa            linear   PRI 05-AUG-2025
DEFINITION  A-kinase anchor protein 11 isoform X4 [Homo sapiens].
ACCESSION   XP_047286034
VERSION     XP_047286034.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430078.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1828
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1828
                     /product="A-kinase anchor protein 11 isoform X4"
                     /calculated_mol_wt=202443
     Region          <1610..1827
                     /region_name="AKAP_110"
                     /note="A-kinase anchor protein 110 kDa (AKAP 110);
                     cl14906"
                     /db_xref="CDD:449376"
     CDS             1..1828
                     /gene="AKAP11"
                     /gene_synonym="AKAP-11; AKAP220; PPP1R44; PRKA11"
                     /coded_by="XM_047430078.1:177..5663"
                     /db_xref="GeneID:11215"
                     /db_xref="HGNC:HGNC:369"
                     /db_xref="MIM:604696"
ORIGIN      
        1 matfrnnhmk tkasvrksfs edvfqsvksl lqsqkelcsv taedclqqde hanltevtfl
       61 gfneetdaah iqshpsgmlc vmrvsptspr lridfifsll skyatgiryt ldtflhqkhq
      121 lettdedddd tnqsvssied dfvtafehle eeetskpynd gmnitvlrsq cdaasqtvtg
      181 hhlethdlki lissgqqksl akpstssvnv lghkelpsvk tsvttsisep wtqrsfyrss
      241 nasdkdsdlq ktffssspay ssesecssps pvifldeegy qkslkaklel pkipvmkddi
      301 edsdsevsef fdsfdqfdel eqtletclfn kdpvigkssq rkghkhgksc mnpqkfkfdr
      361 palpanvrkp tprkpespyg nlcdapdspr pvkasredsg lfspirssaf splggctpae
      421 cfcqtdiggd rihenhdsvy ytyedyaksi scevlgsvlr thhtntlsni nsikhgenkt
      481 vtfkhgnldq knksknkslm ikdsiqkfaa dlveksfgsa fkdlqkgvss ctnalyhlai
      541 kltssvlqma fdelrrqraf slkeraisgl anflvseals nalkdlqyvk kqiftntvar
      601 faadlaeelv fegimevcqf sypqtpaspq cgsfdfedkv vklyakdlse sviqeafiel
      661 sqvdvtfttk aavsvstdni kyvsaesvvp stqavtfsps fhnqaimvtk pvqeykkeyt
      721 vqqalfctsg ivtsipvpla gsallpyhis stacqakahl ssddsnsngd saqvhiatkn
      781 reekaaclrn iclpsehnpg nqndfkptnd diemqssskl pndpaiisnf saavvhtivn
      841 etlesmtsle vtkmvdertd yltkslkekt ppfshcdqav lqcseassnk dmfadrlsks
      901 iikhsidksk svipnidkna vykeslpvsg eesqltpeks pkfpdsqnql thcslsaakd
      961 cvpeckvsmv hgssletlps cpavtgqksd lkesakdqpl kkhnlnstsl ealsfgqenp
     1021 fphshtfsst altcvdglhv edkqkvrdrn vipdtppstp lvpsrassew dikkltkklk
     1081 gelakefapa tppstphnss vgslseneqn tiekeefmlk lmrslseeve ssesgelpev
     1141 dvksehsgkk vqfaealath ilslatemaa shldnkiiqe pkvknpclnv qsqrsvsptf
     1201 lnpsdenlkt lcnfagdlaa eviteaekia kvrncmlfkq kknscyadgd edykveekld
     1261 ieavvhprev dpfilslpps scmsglmyky pscesvtdey aghliqilkq eggnselimd
     1321 qyanrlayrs vksglqeaak ttkvqcnsrm fpvpssqvkt nkellmfsnk ehhqeadkkr
     1381 qskrnegyfc knqtcertld pyrnevsqly sfstslvhsi tkdakeelta slvglpkslt
     1441 dsclfeksgy eednechvtp elpkslqpss qnhrfyhstg slngygcgdn vvqaveqyak
     1501 kvvddtlelt lgstvfrvse ttksadrvty aeklspltgq acrycdlkel hnctgnssqh
     1561 ffrqgslass kpasnpkfss ryqksrifhl svpqihvnld kkavlaekiv aeaiekaere
     1621 lsstslaads gigqegasfa eslatetmta avtnvghavs sskeiedfqs tesvssqqmn
     1681 lsigddstgs wsnlsfedeh qdesssfhhl sesdgpddkd eehedevegl gqdgktllit
     1741 nidmepctvd pqlriilqwl iaseaevael yfhdsankef mllskqlqek gwkvgdllqa
     1801 vlqyyevmek asseercksl fdwllena
//
LOCUS       XP_047286035            1828 aa            linear   PRI 05-AUG-2025
DEFINITION  A-kinase anchor protein 11 isoform X4 [Homo sapiens].
ACCESSION   XP_047286035
VERSION     XP_047286035.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430079.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1828
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1828
                     /product="A-kinase anchor protein 11 isoform X4"
                     /calculated_mol_wt=202443
     Region          <1610..1827
                     /region_name="AKAP_110"
                     /note="A-kinase anchor protein 110 kDa (AKAP 110);
                     cl14906"
                     /db_xref="CDD:449376"
     CDS             1..1828
                     /gene="AKAP11"
                     /gene_synonym="AKAP-11; AKAP220; PPP1R44; PRKA11"
                     /coded_by="XM_047430079.1:162..5648"
                     /db_xref="GeneID:11215"
                     /db_xref="HGNC:HGNC:369"
                     /db_xref="MIM:604696"
ORIGIN      
        1 matfrnnhmk tkasvrksfs edvfqsvksl lqsqkelcsv taedclqqde hanltevtfl
       61 gfneetdaah iqshpsgmlc vmrvsptspr lridfifsll skyatgiryt ldtflhqkhq
      121 lettdedddd tnqsvssied dfvtafehle eeetskpynd gmnitvlrsq cdaasqtvtg
      181 hhlethdlki lissgqqksl akpstssvnv lghkelpsvk tsvttsisep wtqrsfyrss
      241 nasdkdsdlq ktffssspay ssesecssps pvifldeegy qkslkaklel pkipvmkddi
      301 edsdsevsef fdsfdqfdel eqtletclfn kdpvigkssq rkghkhgksc mnpqkfkfdr
      361 palpanvrkp tprkpespyg nlcdapdspr pvkasredsg lfspirssaf splggctpae
      421 cfcqtdiggd rihenhdsvy ytyedyaksi scevlgsvlr thhtntlsni nsikhgenkt
      481 vtfkhgnldq knksknkslm ikdsiqkfaa dlveksfgsa fkdlqkgvss ctnalyhlai
      541 kltssvlqma fdelrrqraf slkeraisgl anflvseals nalkdlqyvk kqiftntvar
      601 faadlaeelv fegimevcqf sypqtpaspq cgsfdfedkv vklyakdlse sviqeafiel
      661 sqvdvtfttk aavsvstdni kyvsaesvvp stqavtfsps fhnqaimvtk pvqeykkeyt
      721 vqqalfctsg ivtsipvpla gsallpyhis stacqakahl ssddsnsngd saqvhiatkn
      781 reekaaclrn iclpsehnpg nqndfkptnd diemqssskl pndpaiisnf saavvhtivn
      841 etlesmtsle vtkmvdertd yltkslkekt ppfshcdqav lqcseassnk dmfadrlsks
      901 iikhsidksk svipnidkna vykeslpvsg eesqltpeks pkfpdsqnql thcslsaakd
      961 cvpeckvsmv hgssletlps cpavtgqksd lkesakdqpl kkhnlnstsl ealsfgqenp
     1021 fphshtfsst altcvdglhv edkqkvrdrn vipdtppstp lvpsrassew dikkltkklk
     1081 gelakefapa tppstphnss vgslseneqn tiekeefmlk lmrslseeve ssesgelpev
     1141 dvksehsgkk vqfaealath ilslatemaa shldnkiiqe pkvknpclnv qsqrsvsptf
     1201 lnpsdenlkt lcnfagdlaa eviteaekia kvrncmlfkq kknscyadgd edykveekld
     1261 ieavvhprev dpfilslpps scmsglmyky pscesvtdey aghliqilkq eggnselimd
     1321 qyanrlayrs vksglqeaak ttkvqcnsrm fpvpssqvkt nkellmfsnk ehhqeadkkr
     1381 qskrnegyfc knqtcertld pyrnevsqly sfstslvhsi tkdakeelta slvglpkslt
     1441 dsclfeksgy eednechvtp elpkslqpss qnhrfyhstg slngygcgdn vvqaveqyak
     1501 kvvddtlelt lgstvfrvse ttksadrvty aeklspltgq acrycdlkel hnctgnssqh
     1561 ffrqgslass kpasnpkfss ryqksrifhl svpqihvnld kkavlaekiv aeaiekaere
     1621 lsstslaads gigqegasfa eslatetmta avtnvghavs sskeiedfqs tesvssqqmn
     1681 lsigddstgs wsnlsfedeh qdesssfhhl sesdgpddkd eehedevegl gqdgktllit
     1741 nidmepctvd pqlriilqwl iaseaevael yfhdsankef mllskqlqek gwkvgdllqa
     1801 vlqyyevmek asseercksl fdwllena
//
LOCUS       XP_047286036            1828 aa            linear   PRI 05-AUG-2025
DEFINITION  A-kinase anchor protein 11 isoform X4 [Homo sapiens].
ACCESSION   XP_047286036
VERSION     XP_047286036.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430080.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1828
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1828
                     /product="A-kinase anchor protein 11 isoform X4"
                     /calculated_mol_wt=202443
     Region          <1610..1827
                     /region_name="AKAP_110"
                     /note="A-kinase anchor protein 110 kDa (AKAP 110);
                     cl14906"
                     /db_xref="CDD:449376"
     CDS             1..1828
                     /gene="AKAP11"
                     /gene_synonym="AKAP-11; AKAP220; PPP1R44; PRKA11"
                     /coded_by="XM_047430080.1:127..5613"
                     /db_xref="GeneID:11215"
                     /db_xref="HGNC:HGNC:369"
                     /db_xref="MIM:604696"
ORIGIN      
        1 matfrnnhmk tkasvrksfs edvfqsvksl lqsqkelcsv taedclqqde hanltevtfl
       61 gfneetdaah iqshpsgmlc vmrvsptspr lridfifsll skyatgiryt ldtflhqkhq
      121 lettdedddd tnqsvssied dfvtafehle eeetskpynd gmnitvlrsq cdaasqtvtg
      181 hhlethdlki lissgqqksl akpstssvnv lghkelpsvk tsvttsisep wtqrsfyrss
      241 nasdkdsdlq ktffssspay ssesecssps pvifldeegy qkslkaklel pkipvmkddi
      301 edsdsevsef fdsfdqfdel eqtletclfn kdpvigkssq rkghkhgksc mnpqkfkfdr
      361 palpanvrkp tprkpespyg nlcdapdspr pvkasredsg lfspirssaf splggctpae
      421 cfcqtdiggd rihenhdsvy ytyedyaksi scevlgsvlr thhtntlsni nsikhgenkt
      481 vtfkhgnldq knksknkslm ikdsiqkfaa dlveksfgsa fkdlqkgvss ctnalyhlai
      541 kltssvlqma fdelrrqraf slkeraisgl anflvseals nalkdlqyvk kqiftntvar
      601 faadlaeelv fegimevcqf sypqtpaspq cgsfdfedkv vklyakdlse sviqeafiel
      661 sqvdvtfttk aavsvstdni kyvsaesvvp stqavtfsps fhnqaimvtk pvqeykkeyt
      721 vqqalfctsg ivtsipvpla gsallpyhis stacqakahl ssddsnsngd saqvhiatkn
      781 reekaaclrn iclpsehnpg nqndfkptnd diemqssskl pndpaiisnf saavvhtivn
      841 etlesmtsle vtkmvdertd yltkslkekt ppfshcdqav lqcseassnk dmfadrlsks
      901 iikhsidksk svipnidkna vykeslpvsg eesqltpeks pkfpdsqnql thcslsaakd
      961 cvpeckvsmv hgssletlps cpavtgqksd lkesakdqpl kkhnlnstsl ealsfgqenp
     1021 fphshtfsst altcvdglhv edkqkvrdrn vipdtppstp lvpsrassew dikkltkklk
     1081 gelakefapa tppstphnss vgslseneqn tiekeefmlk lmrslseeve ssesgelpev
     1141 dvksehsgkk vqfaealath ilslatemaa shldnkiiqe pkvknpclnv qsqrsvsptf
     1201 lnpsdenlkt lcnfagdlaa eviteaekia kvrncmlfkq kknscyadgd edykveekld
     1261 ieavvhprev dpfilslpps scmsglmyky pscesvtdey aghliqilkq eggnselimd
     1321 qyanrlayrs vksglqeaak ttkvqcnsrm fpvpssqvkt nkellmfsnk ehhqeadkkr
     1381 qskrnegyfc knqtcertld pyrnevsqly sfstslvhsi tkdakeelta slvglpkslt
     1441 dsclfeksgy eednechvtp elpkslqpss qnhrfyhstg slngygcgdn vvqaveqyak
     1501 kvvddtlelt lgstvfrvse ttksadrvty aeklspltgq acrycdlkel hnctgnssqh
     1561 ffrqgslass kpasnpkfss ryqksrifhl svpqihvnld kkavlaekiv aeaiekaere
     1621 lsstslaads gigqegasfa eslatetmta avtnvghavs sskeiedfqs tesvssqqmn
     1681 lsigddstgs wsnlsfedeh qdesssfhhl sesdgpddkd eehedevegl gqdgktllit
     1741 nidmepctvd pqlriilqwl iaseaevael yfhdsankef mllskqlqek gwkvgdllqa
     1801 vlqyyevmek asseercksl fdwllena
//
LOCUS       XP_005266306            1824 aa            linear   PRI 05-AUG-2025
DEFINITION  A-kinase anchor protein 11 isoform X5 [Homo sapiens].
ACCESSION   XP_005266306
VERSION     XP_005266306.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266249.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1824
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1824
                     /product="A-kinase anchor protein 11 isoform X5"
                     /calculated_mol_wt=201395
     CDS             1..1824
                     /gene="AKAP11"
                     /gene_synonym="AKAP-11; AKAP220; PPP1R44; PRKA11"
                     /coded_by="XM_005266249.4:177..5651"
                     /db_xref="GeneID:11215"
                     /db_xref="HGNC:HGNC:369"
                     /db_xref="MIM:604696"
ORIGIN      
        1 matfrnnhmk tkasvrksfs edvfqsvksl lqsqkelcsv taedclqqde hanltevtfl
       61 gfneetdaah iqdlaavsle lpdilnslhf cslneneiic mkninkpldi ssdplnqshp
      121 sgmlcvmrvs ptsprlridf ifsllskyat girytldtfl hqkhqlettd eddddtnqsv
      181 ssieddfvta fehleeeets kpyndgmnit vlrsqcdaas qtvtghhlet hdlkilissg
      241 qqkslakpst ssvnvlghke lpsvktsvtt sisepwtqrs fyrssnasdk dsdlqktffs
      301 sspayssese csspspvifl deegyqkslk aklelpkipv mkddiedsds evseffdsfd
      361 qfdeleqtle tclfnkdpvi gkssqrkghk hgkscmnpqk fkfdrpalpa nvrkptprkp
      421 espygnlcda pdsprpvkas redsglfspi rssafsplgg ctpaecfcqt diggdrihen
      481 hdsvyytyed yaksiscevl gsvlrthhtn tlsninsikh genktvtfkh gnldqknksk
      541 nkslmikdsi qkfaadlvek sfgsafkdlq kgvssctnal yhlaikltss vlqmafdelr
      601 rqrafslker aisglanflv sealsnalkd lqyvkkqift ntvarfaadl aeelvfegim
      661 evcqfsypqt paspqcgsfd fedkvvklya kdlsesviqe afielsqvdv tfttkaavsv
      721 stdnikyvsa esvvpstqav tfspsfhnqa imvtkpvqey kkeytvqqal fctsgivtsi
      781 pvplagsall pyhisstacq akahlssdds nsngdsaqvh iatknreeka aclrniclps
      841 ehnpgnqndf kptnddiemq sssklpndpa iisnfsaavv htivnetles mtslevtkmv
      901 dertdyltks lkektppfsh cdqavlqcse assnkdmfad rlsksiikhs idksksvipn
      961 idknavykes lpvsgeesql tpekspkfpd sqnqlthcsl saakdcvpec kvsmvhgssl
     1021 etlpscpavt gqksdlkesa kdqplkkhnl nstslealsf gqenpfphsh tfsstaltcv
     1081 dglhvedkqk vrdrnvipdt ppstplvpsr assewdikkl tkklkgelak efapatppst
     1141 phnssvgsls eneqntieke efmlklmrsl seevessesg elpevdvkse hsgkkvqfae
     1201 alathilsla temaashldn kiiqepkvkn pclnvqsqrs vsptflnpsd enlktlcnfa
     1261 gdlaaevite aekiakvrnc mlfkqkknsc yadgdedykv eekldieavv hprevdpfil
     1321 slppsscmsg lmykypsces vtdeyaghli qilkqeggns elimdqyanr layrsvksgl
     1381 qeaakttkvq cnsrmfpvps sqvktnkell mfsnkehhqe adkkrqskrn egyfcknqtc
     1441 ertldpyrne vsqlysfsts lvhsitkdak eeltaslvgl pksltdsclf eksgyeedne
     1501 chvtpelpks lqpssqnhrf yhstgslngy gcgdnvvqav eqyakkvvdd tleltlgstv
     1561 frvsettksa drvtyaekls pltgqacryc dlkelhnctg nssqhffrqg slasskpasn
     1621 pkfssryqks rifhlsvpqi hvnldkkavl aekivaeaie kaerelssts laadsgigqe
     1681 gasfaeslat etmtaavtnv ghavssskei edfqstesvs sqqmnlsigd dstgswsnls
     1741 fedehqdess sfhhlsesng nssswsslgl egdlyednls fptsdsdgpd dkdeehedev
     1801 eafktitrer mesgrppagc asil
//
LOCUS       XP_005266307            1796 aa            linear   PRI 05-AUG-2025
DEFINITION  A-kinase anchor protein 11 isoform X6 [Homo sapiens].
ACCESSION   XP_005266307
VERSION     XP_005266307.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266250.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1796
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1796
                     /product="A-kinase anchor protein 11 isoform X6"
                     /calculated_mol_wt=198434
     CDS             1..1796
                     /gene="AKAP11"
                     /gene_synonym="AKAP-11; AKAP220; PPP1R44; PRKA11"
                     /coded_by="XM_005266250.4:177..5567"
                     /db_xref="GeneID:11215"
                     /db_xref="HGNC:HGNC:369"
                     /db_xref="MIM:604696"
ORIGIN      
        1 matfrnnhmk tkasvrksfs edvfqsvksl lqsqkelcsv taedclqqde hanltevtfl
       61 gfneetdaah iqdlaavsle lpdilnslhf cslneneiic mkninkpldi ssdplnqshp
      121 sgmlcvmrvs ptsprlridf ifsllskyat girytldtfl hqkhqlettd eddddtnqsv
      181 ssieddfvta fehleeeets kpyndgmnit vlrsqcdaas qtvtghhlet hdlkilissg
      241 qqkslakpst ssvnvlghke lpsvktsvtt sisepwtqrs fyrssnasdk dsdlqktffs
      301 sspayssese csspspvifl deegyqkslk aklelpkipv mkddiedsds evseffdsfd
      361 qfdeleqtle tclfnkdpvi gkssqrkghk hgkscmnpqk fkfdrpalpa nvrkptprkp
      421 espygnlcda pdsprpvkas redsglfspi rssafsplgg ctpaecfcqt diggdrihen
      481 hdsvyytyed yaksiscevl gsvlrthhtn tlsninsikh genktvtfkh gnldqknksk
      541 nkslmikdsi qkfaadlvek sfgsafkdlq kgvssctnal yhlaikltss vlqmafdelr
      601 rqrafslker aisglanflv sealsnalkd lqyvkkqift ntvarfaadl aeelvfegim
      661 evcqfsypqt paspqcgsfd fedkvvklya kdlsesviqe afielsqvdv tfttkaavsv
      721 stdnikyvsa esvvpstqav tfspsfhnqa imvtkpvqey kkeytvqqal fctsgivtsi
      781 pvplagsall pyhisstacq akahlssdds nsngdsaqvh iatknreeka aclrniclps
      841 ehnpgnqndf kptnddiemq sssklpndpa iisnfsaavv htivnetles mtslevtkmv
      901 dertdyltks lkektppfsh cdqavlqcse assnkdmfad rlsksiikhs idksksvipn
      961 idknavykes lpvsgeesql tpekspkfpd sqnqlthcsl saakdcvpec kvsmvhgssl
     1021 etlpscpavt gqksdlkesa kdqplkkhnl nstslealsf gqenpfphsh tfsstaltcv
     1081 dglhvedkqk vrdrnvipdt ppstplvpsr assewdikkl tkklkgelak efapatppst
     1141 phnssvgsls eneqntieke efmlklmrsl seevessesg elpevdvkse hsgkkvqfae
     1201 alathilsla temaashldn kiiqepkvkn pclnvqsqrs vsptflnpsd enlktlcnfa
     1261 gdlaaevite aekiakvrnc mlfkqkknsc yadgdedykv eekldieavv hprevdpfil
     1321 slppsscmsg lmykypsces vtdeyaghli qilkqeggns elimdqyanr layrsvksgl
     1381 qeaakttkvq cnsrmfpvps sqvktnkell mfsnkehhqe adkkrqskrn egyfcknqtc
     1441 ertldpyrne vsqlysfsts lvhsitkdak eeltaslvgl pksltdsclf eksgyeedne
     1501 chvtpelpks lqpssqnhrf yhstgslngy gcgdnvvqav eqyakkvvdd tleltlgstv
     1561 frvsettksa drvtyaekls pltgqacryc dlkelhnctg nssqhffrqg slasskpasn
     1621 pkfssryqks rifhlsvpqi hvnldkkavl aekivaeaie kaerelssts laadsgigqe
     1681 gasfaeslat etmtaavtnv ghavssskei edfqstesvs sqqmnlsigd dstgswsnls
     1741 fedehqdess sfhhlsesdg pddkdeehed eveafktitr ermesgrppa gcasil
//
LOCUS       XP_011533209             415 aa            linear   PRI 05-AUG-2025
DEFINITION  Krueppel-like factor 12 isoform X1 [Homo sapiens].
ACCESSION   XP_011533209
VERSION     XP_011533209.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534907.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..415
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..415
                     /product="Krueppel-like factor 12 isoform X1"
                     /calculated_mol_wt=45443
     Region          40..237
                     /region_name="KLF12_N"
                     /note="N-terminal domain of Kruppel-like factor 12;
                     cd21441"
                     /db_xref="CDD:410608"
     Region          <241..414
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          332..354
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(339,341,343,345..346,349..350,353,369,371,375..376,
                     379..380,383,397,399,401,403..404,407..408,411)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          362..384
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          376..401
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          392..412
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..415
                     /gene="KLF12"
                     /gene_synonym="AP-2rep; AP2REP; HSPC122"
                     /coded_by="XM_011534907.3:78..1325"
                     /db_xref="GeneID:11278"
                     /db_xref="HGNC:HGNC:6346"
                     /db_xref="MIM:607531"
ORIGIN      
        1 mvwmsqfics ptegylgwsl llatnintfe nrmlmldgmp avrvktelle seqgspnvhn
       61 ypdmeavpll lnnvkgeppe dslsvdhfqt qtepvdlsin kartsptavs sspvsmtasa
      121 sspsststss ssssrlassp tvitsvssas ssstvltpgp lvasasgvgg qqflhiihpv
      181 ppsspmnlqs nklshvhrip vvvqsvpvvy tavrspgnvn ntivvplled grghgkaqmd
      241 prglsprqsk sdsddddlpn vtldsvnetg stalsiarav qevhpspvsr vrgnrmnnqk
      301 fpcsispfsi estrrqrrse spdsrkrrih rcdfegcnkv ytksshlkah rrthtgekpy
      361 kctwegctwk farsdeltrh yrkhtgvkpf kcadcdrsfs rsdhlalhrr rhmlv
//
LOCUS       XP_011533210             403 aa            linear   PRI 05-AUG-2025
DEFINITION  Krueppel-like factor 12 isoform X2 [Homo sapiens].
ACCESSION   XP_011533210
VERSION     XP_011533210.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534908.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..403
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..403
                     /product="Krueppel-like factor 12 isoform X2"
                     /calculated_mol_wt=44056
     Region          40..237
                     /region_name="KLF12_N"
                     /note="N-terminal domain of Kruppel-like factor 12;
                     cd21441"
                     /db_xref="CDD:410608"
     Region          330..354
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          332..354
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..403
                     /gene="KLF12"
                     /gene_synonym="AP-2rep; AP2REP; HSPC122"
                     /coded_by="XM_011534908.4:78..1289"
                     /db_xref="GeneID:11278"
                     /db_xref="HGNC:HGNC:6346"
                     /db_xref="MIM:607531"
ORIGIN      
        1 mvwmsqfics ptegylgwsl llatnintfe nrmlmldgmp avrvktelle seqgspnvhn
       61 ypdmeavpll lnnvkgeppe dslsvdhfqt qtepvdlsin kartsptavs sspvsmtasa
      121 sspsststss ssssrlassp tvitsvssas ssstvltpgp lvasasgvgg qqflhiihpv
      181 ppsspmnlqs nklshvhrip vvvqsvpvvy tavrspgnvn ntivvplled grghgkaqmd
      241 prglsprqsk sdsddddlpn vtldsvnetg stalsiarav qevhpspvsr vrgnrmnnqk
      301 fpcsispfsi estrrqrrse spdsrkrrih rcdfegcnkv ytksshlkah rrthtgcsgr
      361 hmsqeehlpr eklsqnlwkr lcnrretlqv ylgrlhlevr sfr
//
LOCUS       XP_011533211             402 aa            linear   PRI 05-AUG-2025
DEFINITION  Krueppel-like factor 12 isoform X3 [Homo sapiens].
ACCESSION   XP_011533211
VERSION     XP_011533211.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534909.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..402
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..402
                     /product="Krueppel-like factor 12 isoform X3"
                     /calculated_mol_wt=44109
     Region          27..224
                     /region_name="KLF12_N"
                     /note="N-terminal domain of Kruppel-like factor 12;
                     cd21441"
                     /db_xref="CDD:410608"
     Region          <228..401
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          319..341
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(326,328,330,332..333,336..337,340,356,358,362..363,
                     366..367,370,384,386,388,390..391,394..395,398)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          349..371
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          363..388
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          379..399
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..402
                     /gene="KLF12"
                     /gene_synonym="AP-2rep; AP2REP; HSPC122"
                     /coded_by="XM_011534909.3:210..1418"
                     /db_xref="GeneID:11278"
                     /db_xref="HGNC:HGNC:6346"
                     /db_xref="MIM:607531"
ORIGIN      
        1 mnihmkrkti knintfenrm lmldgmpavr vktelleseq gspnvhnypd meavplllnn
       61 vkgeppedsl svdhfqtqte pvdlsinkar tsptavsssp vsmtasassp sststsssss
      121 srlassptvi tsvssassss tvltpgplva sasgvggqqf lhiihpvpps spmnlqsnkl
      181 shvhripvvv qsvpvvytav rspgnvnnti vvplledgrg hgkaqmdprg lsprqsksds
      241 ddddlpnvtl dsvnetgsta lsiaravqev hpspvsrvrg nrmnnqkfpc sispfsiest
      301 rrqrrsespd srkrrihrcd fegcnkvytk sshlkahrrt htgekpykct wegctwkfar
      361 sdeltrhyrk htgvkpfkca dcdrsfsrsd hlalhrrrhm lv
//
LOCUS       XP_011533212             400 aa            linear   PRI 05-AUG-2025
DEFINITION  Krueppel-like factor 12 isoform X4 [Homo sapiens].
ACCESSION   XP_011533212
VERSION     XP_011533212.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534910.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..400
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..400
                     /product="Krueppel-like factor 12 isoform X4"
                     /calculated_mol_wt=43687
     Region          25..222
                     /region_name="KLF12_N"
                     /note="N-terminal domain of Kruppel-like factor 12;
                     cd21441"
                     /db_xref="CDD:410608"
     Region          <226..399
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          317..339
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(324,326,328,330..331,334..335,338,354,356,360..361,
                     364..365,368,382,384,386,388..389,392..393,396)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          347..369
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          361..386
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          377..397
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..400
                     /gene="KLF12"
                     /gene_synonym="AP-2rep; AP2REP; HSPC122"
                     /coded_by="XM_011534910.3:1651..2853"
                     /db_xref="GeneID:11278"
                     /db_xref="HGNC:HGNC:6346"
                     /db_xref="MIM:607531"
ORIGIN      
        1 mlrvqacgtn intfenrmlm ldgmpavrvk telleseqgs pnvhnypdme avplllnnvk
       61 geppedslsv dhfqtqtepv dlsinkarts ptavssspvs mtasasspss tstssssssr
      121 lassptvits vssasssstv ltpgplvasa sgvggqqflh iihpvppssp mnlqsnklsh
      181 vhripvvvqs vpvvytavrs pgnvnntivv plledgrghg kaqmdprgls prqsksdsdd
      241 ddlpnvtlds vnetgstals iaravqevhp spvsrvrgnr mnnqkfpcsi spfsiestrr
      301 qrrsespdsr krrihrcdfe gcnkvytkss hlkahrrtht gekpykctwe gctwkfarsd
      361 eltrhyrkht gvkpfkcadc drsfsrsdhl alhrrrhmlv
//
LOCUS       XP_047286038             390 aa            linear   PRI 05-AUG-2025
DEFINITION  Krueppel-like factor 12 isoform X5 [Homo sapiens].
ACCESSION   XP_047286038
VERSION     XP_047286038.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430082.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..390
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..390
                     /product="Krueppel-like factor 12 isoform X5"
                     /calculated_mol_wt=42721
     Region          27..224
                     /region_name="KLF12_N"
                     /note="N-terminal domain of Kruppel-like factor 12;
                     cd21441"
                     /db_xref="CDD:410608"
     Region          317..341
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          319..341
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..390
                     /gene="KLF12"
                     /gene_synonym="AP-2rep; AP2REP; HSPC122"
                     /coded_by="XM_047430082.1:465..1637"
                     /db_xref="GeneID:11278"
                     /db_xref="HGNC:HGNC:6346"
                     /db_xref="MIM:607531"
ORIGIN      
        1 mnihmkrkti knintfenrm lmldgmpavr vktelleseq gspnvhnypd meavplllnn
       61 vkgeppedsl svdhfqtqte pvdlsinkar tsptavsssp vsmtasassp sststsssss
      121 srlassptvi tsvssassss tvltpgplva sasgvggqqf lhiihpvpps spmnlqsnkl
      181 shvhripvvv qsvpvvytav rspgnvnnti vvplledgrg hgkaqmdprg lsprqsksds
      241 ddddlpnvtl dsvnetgsta lsiaravqev hpspvsrvrg nrmnnqkfpc sispfsiest
      301 rrqrrsespd srkrrihrcd fegcnkvytk sshlkahrrt htgcsgrhms qeehlprekl
      361 sqnlwkrlcn rretlqvylg rlhlevrsfr
//
LOCUS       XP_011533213             383 aa            linear   PRI 05-AUG-2025
DEFINITION  Krueppel-like factor 12 isoform X6 [Homo sapiens].
ACCESSION   XP_011533213
VERSION     XP_011533213.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534911.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..383
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..383
                     /product="Krueppel-like factor 12 isoform X6"
                     /calculated_mol_wt=41738
     Region          8..205
                     /region_name="KLF12_N"
                     /note="N-terminal domain of Kruppel-like factor 12;
                     cd21441"
                     /db_xref="CDD:410608"
     Region          <209..382
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          300..322
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(307,309,311,313..314,317..318,321,337,339,343..344,
                     347..348,351,365,367,369,371..372,375..376,379)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          330..352
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          344..369
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          360..380
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..383
                     /gene="KLF12"
                     /gene_synonym="AP-2rep; AP2REP; HSPC122"
                     /coded_by="XM_011534911.3:155..1306"
                     /db_xref="GeneID:11278"
                     /db_xref="HGNC:HGNC:6346"
                     /db_xref="MIM:607531"
ORIGIN      
        1 mlmldgmpav rvktellese qgspnvhnyp dmeavpllln nvkgeppeds lsvdhfqtqt
       61 epvdlsinka rtsptavsss pvsmtasass psststssss ssrlassptv itsvssasss
      121 stvltpgplv asasgvggqq flhiihpvpp sspmnlqsnk lshvhripvv vqsvpvvyta
      181 vrspgnvnnt ivvplledgr ghgkaqmdpr glsprqsksd sddddlpnvt ldsvnetgst
      241 alsiaravqe vhpspvsrvr gnrmnnqkfp csispfsies trrqrrsesp dsrkrrihrc
      301 dfegcnkvyt ksshlkahrr thtgekpykc twegctwkfa rsdeltrhyr khtgvkpfkc
      361 adcdrsfsrs dhlalhrrrh mlv
//
LOCUS       XP_047286039             383 aa            linear   PRI 05-AUG-2025
DEFINITION  Krueppel-like factor 12 isoform X6 [Homo sapiens].
ACCESSION   XP_047286039
VERSION     XP_047286039.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430083.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..383
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..383
                     /product="Krueppel-like factor 12 isoform X6"
                     /calculated_mol_wt=41738
     Region          8..205
                     /region_name="KLF12_N"
                     /note="N-terminal domain of Kruppel-like factor 12;
                     cd21441"
                     /db_xref="CDD:410608"
     Region          <209..382
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          300..322
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(307,309,311,313..314,317..318,321,337,339,343..344,
                     347..348,351,365,367,369,371..372,375..376,379)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          330..352
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          344..369
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          360..380
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..383
                     /gene="KLF12"
                     /gene_synonym="AP-2rep; AP2REP; HSPC122"
                     /coded_by="XM_047430083.1:546..1697"
                     /db_xref="GeneID:11278"
                     /db_xref="HGNC:HGNC:6346"
                     /db_xref="MIM:607531"
ORIGIN      
        1 mlmldgmpav rvktellese qgspnvhnyp dmeavpllln nvkgeppeds lsvdhfqtqt
       61 epvdlsinka rtsptavsss pvsmtasass psststssss ssrlassptv itsvssasss
      121 stvltpgplv asasgvggqq flhiihpvpp sspmnlqsnk lshvhripvv vqsvpvvyta
      181 vrspgnvnnt ivvplledgr ghgkaqmdpr glsprqsksd sddddlpnvt ldsvnetgst
      241 alsiaravqe vhpspvsrvr gnrmnnqkfp csispfsies trrqrrsesp dsrkrrihrc
      301 dfegcnkvyt ksshlkahrr thtgekpykc twegctwkfa rsdeltrhyr khtgvkpfkc
      361 adcdrsfsrs dhlalhrrrh mlv
//
LOCUS       XP_047286040             383 aa            linear   PRI 05-AUG-2025
DEFINITION  Krueppel-like factor 12 isoform X6 [Homo sapiens].
ACCESSION   XP_047286040
VERSION     XP_047286040.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430084.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..383
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..383
                     /product="Krueppel-like factor 12 isoform X6"
                     /calculated_mol_wt=41738
     Region          8..205
                     /region_name="KLF12_N"
                     /note="N-terminal domain of Kruppel-like factor 12;
                     cd21441"
                     /db_xref="CDD:410608"
     Region          <209..382
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          300..322
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(307,309,311,313..314,317..318,321,337,339,343..344,
                     347..348,351,365,367,369,371..372,375..376,379)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          330..352
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          344..369
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          360..380
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..383
                     /gene="KLF12"
                     /gene_synonym="AP-2rep; AP2REP; HSPC122"
                     /coded_by="XM_047430084.1:304..1455"
                     /db_xref="GeneID:11278"
                     /db_xref="HGNC:HGNC:6346"
                     /db_xref="MIM:607531"
ORIGIN      
        1 mlmldgmpav rvktellese qgspnvhnyp dmeavpllln nvkgeppeds lsvdhfqtqt
       61 epvdlsinka rtsptavsss pvsmtasass psststssss ssrlassptv itsvssasss
      121 stvltpgplv asasgvggqq flhiihpvpp sspmnlqsnk lshvhripvv vqsvpvvyta
      181 vrspgnvnnt ivvplledgr ghgkaqmdpr glsprqsksd sddddlpnvt ldsvnetgst
      241 alsiaravqe vhpspvsrvr gnrmnnqkfp csispfsies trrqrrsesp dsrkrrihrc
      301 dfegcnkvyt ksshlkahrr thtgekpykc twegctwkfa rsdeltrhyr khtgvkpfkc
      361 adcdrsfsrs dhlalhrrrh mlv
//
LOCUS       XP_047286042            1885 aa            linear   PRI 05-AUG-2025
DEFINITION  inactive ADP-ribosyltransferase ARH2 isoform X1 [Homo sapiens].
ACCESSION   XP_047286042
VERSION     XP_047286042.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430086.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1885
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1885
                     /product="inactive ADP-ribosyltransferase ARH2 isoform X1"
                     /calculated_mol_wt=202570
     Region          <1..268
                     /region_name="DraG"
                     /note="ADP-ribosylglycohydrolase [Posttranslational
                     modification, protein turnover, chaperones]; COG1397"
                     /db_xref="CDD:441007"
     Region          <50..246
                     /region_name="ADP_ribosyl_GH"
                     /note="ADP-ribosylglycohydrolase; pfam03747"
                     /db_xref="CDD:461037"
     Region          <574..759
                     /region_name="PRK07764"
                     /note="DNA polymerase III subunits gamma and tau;
                     Validated"
                     /db_xref="CDD:236090"
     Region          <1030..1424
                     /region_name="PRK07764"
                     /note="DNA polymerase III subunits gamma and tau;
                     Validated"
                     /db_xref="CDD:236090"
     Region          <1450..>1675
                     /region_name="wall_bind_EntB"
                     /note="cell wall-binding protein EntB; NF040676"
                     /db_xref="CDD:468642"
     Region          1521..>1846
                     /region_name="TolA"
                     /note="Membrane protein TolA involved in colicin uptake
                     [Cell wall/membrane/envelope biogenesis]; COG3064"
                     /db_xref="CDD:442298"
     CDS             1..1885
                     /gene="ADPRHL1"
                     /gene_synonym="ARH2"
                     /coded_by="XM_047430086.1:3809..9466"
                     /db_xref="GeneID:113622"
                     /db_xref="HGNC:HGNC:21303"
                     /db_xref="MIM:610620"
ORIGIN      
        1 mvrcyveive klperrpdpa tiegcaqlkp nnyllawhtp fnekgsgfga atkamciglr
       61 ywkperletl ievsvecgrm thnhptgflg slctalfvsf aaqgkplvqw grdmlravpl
      121 aeeycrktir htaeyqehwf yfeakwqfyl eerkiskdse nkaifpdnyd aeerektyrk
      181 wssegrggrr ghdapmiayd allaagnswt elchramfhg gesaatgtia gclfgllygl
      241 dlvpkglyqd ledkekledl gaalyrlste enrkssktcs dvmsvdaqtl kkkmgklacd
      301 paahsilssl llyvtgradr ppgteaggsr pshqpqtqea tqrptrfqll qakflgtgre
      361 rylkrtrevg rliskdkqgp ggglvgatin kllektkepa pkpclsekpr wghpagkstv
      421 knilkiflaa eekeakekea rekppverpk aargllpkim gkssvlsklr ekfeqnsclc
      481 seasalrlht qerkkrnlqr krmhrpevrv lhtatmastc vkmpparfla ctaeplpals
      541 iatvvcgprs wlshctkish searrpprge asvppsaret gpsgnkavgk gpleeepqrq
      601 prpskpvtpq vmaqrdghav pslafscapc tggvlpglvp assplgpasp wgtgsaggdg
      661 tadptaesta ggvqevrgar ltwppgppge cagegpeitm tvcssedere gagfpdpgrd
      721 plfatqkyfp eqkvpehipp lnapsvqaar rtqpateppr itvqipvvhe mpapptrlqn
      781 mssgenkpci cggenvvena htefptvten rrghrapvel sklsgmqagl sasspqgpra
      841 aprlaaarga vgadhsvpet lltqrlqtdp aggkenkgsf enshgprnpd disgertsel
      901 rdvkhplpes neismqkkgs atndpaasqn llrgntshas ssqqvpsptg rnptgaptsl
      961 aasskgrtgp egvtpmgmtv pgaleecrrp lliessqplk aaeeitshdv renplsslne
     1021 ppkpgmkacg amaaagsvas ratpapapgs tqspgdrtag epetlgqwgs ralseshprg
     1081 ealprdphsh gllapggsle pksgaagrsl lrgvalvqhp ediatlarhp edaaalarhp
     1141 eaarlyisnt saasrhtaav ggrkdvaveg nllgfstesg ipasdhprpq arsvaespsy
     1201 gpglppsppe npqakgregv rfprgaepdh llpavppaev dmgwvggthq rgpphlqahl
     1261 pptagdtqak lrasvpeprt qagesqerpl tqadlgrqqs hqaqeetpqp gdagkrvaps
     1321 gskvvlnpak epqtwwaqdl agdkgmaigv ggacqrsdqg qqhlqgpwee rgrstawgeg
     1381 traarnpavp pgepegpgsp aaqgqaqkqv qewdrgqvqg haqeqaqwqt qieaqgqaqe
     1441 qaqggtqghs qgqaqkqfqn waqgqaqgha qeqaqwqtqi eaqgqaqepa qggaqgqvqg
     1501 qaqkwaqgqi qgqaqkqvqg evqkwaqeea qgqaqwqtqi kaqkwaqeqt qkgaqervqg
     1561 qaqkgaqera qeqaqeqtqi eaqgqaqkga qerareqaqk gaqerareqa qkgaqerare
     1621 qaqkgaqera reqaqkgaqe rareqaqkga qerareqaqk gaqeraqeqg reqthieaqg
     1681 qaqkgaqewa rdrardqgwe qtqietqrqt qkgaqerawe qgreqaltsg mapraweqpi
     1741 sgiaegvdaa grsggsrspa prdggqsggs glgepsagyp ppgsrplrgk siatsplglg
     1801 ksptepkpea ggcgtpqapa qegspdhpga eralqdrmea seperrgrsr hlakykaqsf
     1861 rdqrafdlsf rpmsvrasdt selpk
//
LOCUS       XP_011535763            1603 aa            linear   PRI 05-AUG-2025
DEFINITION  inactive ADP-ribosyltransferase ARH2 isoform X2 [Homo sapiens].
ACCESSION   XP_011535763
VERSION     XP_011535763.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537461.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1603
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1603
                     /product="inactive ADP-ribosyltransferase ARH2 isoform X2"
                     /calculated_mol_wt=170522
     Region          <748..1142
                     /region_name="PRK07764"
                     /note="DNA polymerase III subunits gamma and tau;
                     Validated"
                     /db_xref="CDD:236090"
     Region          <1168..>1393
                     /region_name="wall_bind_EntB"
                     /note="cell wall-binding protein EntB; NF040676"
                     /db_xref="CDD:468642"
     Region          1239..>1564
                     /region_name="TolA"
                     /note="Membrane protein TolA involved in colicin uptake
                     [Cell wall/membrane/envelope biogenesis]; COG3064"
                     /db_xref="CDD:442298"
     CDS             1..1603
                     /gene="ADPRHL1"
                     /gene_synonym="ARH2"
                     /coded_by="XM_011537461.3:272..5083"
                     /db_xref="GeneID:113622"
                     /db_xref="HGNC:HGNC:21303"
                     /db_xref="MIM:610620"
ORIGIN      
        1 msvdaqtlkk kmgklacdpa ahsilsslll yvtgradrpp gteaggsrps hqpqtqeatq
       61 rptrfqllqa kflgtgrery lkrtrevgrl iskdkqgpgg glvgatinkl lektkepapk
      121 pclsekprwg hpagkstvkn ilkiflaaee keakekeare kppverpkaa rgllpkimgk
      181 ssvlsklrek feqnsclcse asalrlhtqe rkkrnlqrkr mhrpevrvlh tatmastcvk
      241 mpparflact aeplpalsia tvvcgprswl shctkishse arrpprgeas vppsaretgp
      301 sgnkavgkgp leeepqrqpr pskpvtpqvm aqrdghavps lafscapctg gvlpglvpas
      361 splgpaspwg tgsaggdgta dptaestagg vqevrgarlt wppgppgeca gegpeitmtv
      421 cssederega gfpdpgrdpl fatqkyfpeq kvpehippln apsvqaarrt qpatepprit
      481 vqipvvhemp apptrlqnms sgenkpcicg genvvenaht efptvtenrr ghrapvelsk
      541 lsgmqaglsa sspqgpraap rlaaargavg adhsvpetll tqrlqtdpag gkenkgsfen
      601 shgprnpddi sgertselrd vkhplpesne ismqkkgsat ndpaasqnll rgntshasss
      661 qqvpsptgrn ptgaptslaa sskgrtgpeg vtpmgmtvpg aleecrrpll iessqplkaa
      721 eeitshdvre nplsslnepp kpgmkacgam aaagsvasra tpapapgstq spgdrtagep
      781 etlgqwgsra lseshprgea lprdphshgl lapggslepk sgaagrsllr gvalvqhped
      841 iatlarhped aaalarhpea arlyisntsa asrhtaavgg rkdvavegnl lgfstesgip
      901 asdhprpqar svaespsygp glppsppenp qakgregvrf prgaepdhll pavppaevdm
      961 gwvggthqrg pphlqahlpp tagdtqaklr asvpeprtqa gesqerpltq adlgrqqshq
     1021 aqeetpqpgd agkrvapsgs kvvlnpakep qtwwaqdlag dkgmaigvgg acqrsdqgqq
     1081 hlqgpweerg rstawgegtr aarnpavppg epegpgspaa qgqaqkqvqe wdrgqvqgha
     1141 qeqaqwqtqi eaqgqaqeqa qggtqghsqg qaqkqfqnwa qgqaqghaqe qaqwqtqiea
     1201 qgqaqepaqg gaqgqvqgqa qkwaqgqiqg qaqkqvqgev qkwaqeeaqg qaqwqtqika
     1261 qkwaqeqtqk gaqervqgqa qkgaqeraqe qaqeqtqiea qgqaqkgaqe rareqaqkga
     1321 qerareqaqk gaqerareqa qkgaqerare qaqkgaqera reqaqkgaqe rareqaqkga
     1381 qeraqeqgre qthieaqgqa qkgaqeward rardqgweqt qietqrqtqk gaqeraweqg
     1441 reqaltsgma praweqpisg iaegvdaagr sggsrspapr dggqsggsgl gepsagyppp
     1501 gsrplrgksi atsplglgks ptepkpeagg cgtpqapaqe gspdhpgaer alqdrmease
     1561 perrgrsrhl akykaqsfrd qrafdlsfrp msvrasdtse lpk
//
LOCUS       XP_011533216             398 aa            linear   PRI 05-AUG-2025
DEFINITION  WD repeat and FYVE domain-containing protein 2 isoform X1 [Homo
            sapiens].
ACCESSION   XP_011533216
VERSION     XP_011533216.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534914.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..398
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..398
                     /product="WD repeat and FYVE domain-containing protein 2
                     isoform X1"
                     /calculated_mol_wt=44745
     Region          <16..272
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          27..64
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          72..132
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          202..239
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          279..348
                     /region_name="FYVE_WDFY1_like"
                     /note="FYVE domain found in WD40 repeat and FYVE
                     domain-containing protein WDFY1 and WDFY2, and similar
                     proteins; cd15718"
                     /db_xref="CDD:277258"
     Site            order(281,285,310..315,317..318,342..344)
                     /site_type="other"
                     /note="putative phosphatidylinositol 3-phosphate binding
                     site [chemical binding]"
                     /db_xref="CDD:277258"
     Region          321..363
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..398
                     /gene="WDFY2"
                     /gene_synonym="PROF; WDF2; ZFYVE22"
                     /coded_by="XM_011534914.2:227..1423"
                     /db_xref="GeneID:115825"
                     /db_xref="HGNC:HGNC:20482"
                     /db_xref="MIM:610418"
ORIGIN      
        1 maaeiqpkpl trkpillqrm egsqevvnma vivpkeegvi svsedrtvrv wlkrdsgqyw
       61 psvyhampsp cscmsfnpet rrlsigldng tisefilsed ynkmtpvkny qahqsrvtmi
      121 lfvlelewvl stgqdkqfaw hcsesgqrlg gyrtsavasg lqfdvetrhv figdhsgqvt
      181 ilkleqenct lvttfrghtg gvtalcwdpv qrvlfsgssd hsvimwdigg rkgtaielqg
      241 hndrvqalsy aqhtrqlisc ggdggivvwn mdverqetpe wldsdscqkc dqpffwnfkq
      301 mwdskkiglr qhhcrkcgka vcgkcsskrs siplmgfefe vrvcdschea itdeerapta
      361 tfhdskhniv hvhfdatrgw lltsgtdkvi kpteplrg
//
LOCUS       XP_024305085             334 aa            linear   PRI 05-AUG-2025
DEFINITION  WD repeat and FYVE domain-containing protein 2 isoform X2 [Homo
            sapiens].
ACCESSION   XP_024305085
VERSION     XP_024305085.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449317.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..334
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..334
                     /product="WD repeat and FYVE domain-containing protein 2
                     isoform X2"
                     /calculated_mol_wt=37493
     Region          2..>210
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          6..46
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          51..84
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          93..131
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          137..174
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          179..217
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          213..282
                     /region_name="FYVE_WDFY1_like"
                     /note="FYVE domain found in WD40 repeat and FYVE
                     domain-containing protein WDFY1 and WDFY2, and similar
                     proteins; cd15718"
                     /db_xref="CDD:277258"
     Site            order(215,219,244..249,251..252,276..278)
                     /site_type="other"
                     /note="putative phosphatidylinositol 3-phosphate binding
                     site [chemical binding]"
                     /db_xref="CDD:277258"
     Region          255..297
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          303..329
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..334
                     /gene="WDFY2"
                     /gene_synonym="PROF; WDF2; ZFYVE22"
                     /coded_by="XM_024449317.2:1880..2884"
                     /db_xref="GeneID:115825"
                     /db_xref="HGNC:HGNC:20482"
                     /db_xref="MIM:610418"
ORIGIN      
        1 mpspcscmsf npetrrlsig ldngtisefi lsedynkmtp vknyqahqsr vtmilfvlel
       61 ewvlstgqdk qfawhcsesg qrlggyrtsa vasglqfdve trhvfigdhs gqvtilkleq
      121 enctlvttfr ghtggvtalc wdpvqrvlfs gssdhsvimw diggrkgtai elqghndrvq
      181 alsyaqhtrq liscggdggi vvwnmdverq etpewldsds cqkcdqpffw nfkqmwdskk
      241 iglrqhhcrk cgkavcgkcs skrssiplmg fefevrvcds cheaitdeer aptatfhdsk
      301 hnivhvhfda trgwlltsgt dkviklwdmt pvvs
//
LOCUS       XP_047286044             311 aa            linear   PRI 05-AUG-2025
DEFINITION  WD repeat and FYVE domain-containing protein 2 isoform X3 [Homo
            sapiens].
ACCESSION   XP_047286044
VERSION     XP_047286044.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430088.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..311
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..311
                     /product="WD repeat and FYVE domain-containing protein 2
                     isoform X3"
                     /calculated_mol_wt=35072
     Region          <11..183
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          28..61
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          70..108
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          114..151
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          156..194
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          190..259
                     /region_name="FYVE_WDFY1_like"
                     /note="FYVE domain found in WD40 repeat and FYVE
                     domain-containing protein WDFY1 and WDFY2, and similar
                     proteins; cd15718"
                     /db_xref="CDD:277258"
     Site            order(192,196,221..226,228..229,253..255)
                     /site_type="other"
                     /note="putative phosphatidylinositol 3-phosphate binding
                     site [chemical binding]"
                     /db_xref="CDD:277258"
     Region          232..274
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          280..306
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..311
                     /gene="WDFY2"
                     /gene_synonym="PROF; WDF2; ZFYVE22"
                     /coded_by="XM_047430088.1:1875..2810"
                     /db_xref="GeneID:115825"
                     /db_xref="HGNC:HGNC:20482"
                     /db_xref="MIM:610418"
ORIGIN      
        1 mqclefilse dynkmtpvkn yqahqsrvtm ilfvlelewv lstgqdkqfa whcsesgqrl
       61 ggyrtsavas glqfdvetrh vfigdhsgqv tilkleqenc tlvttfrght ggvtalcwdp
      121 vqrvlfsgss dhsvimwdig grkgtaielq ghndrvqals yaqhtrqlis cggdggivvw
      181 nmdverqetp ewldsdscqk cdqpffwnfk qmwdskkigl rqhhcrkcgk avcgkcsskr
      241 ssiplmgfef evrvcdsche aitdeerapt atfhdskhni vhvhfdatrg wlltsgtdkv
      301 iklwdmtpvv s
//
LOCUS       XP_011533217             311 aa            linear   PRI 05-AUG-2025
DEFINITION  WD repeat and FYVE domain-containing protein 2 isoform X3 [Homo
            sapiens].
ACCESSION   XP_011533217
VERSION     XP_011533217.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534915.3
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 35% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..311
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..311
                     /product="WD repeat and FYVE domain-containing protein 2
                     isoform X3"
                     /calculated_mol_wt=35072
     Region          <11..183
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          28..61
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          70..108
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          114..151
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          156..194
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          190..259
                     /region_name="FYVE_WDFY1_like"
                     /note="FYVE domain found in WD40 repeat and FYVE
                     domain-containing protein WDFY1 and WDFY2, and similar
                     proteins; cd15718"
                     /db_xref="CDD:277258"
     Site            order(192,196,221..226,228..229,253..255)
                     /site_type="other"
                     /note="putative phosphatidylinositol 3-phosphate binding
                     site [chemical binding]"
                     /db_xref="CDD:277258"
     Region          232..274
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          280..306
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..311
                     /gene="WDFY2"
                     /gene_synonym="PROF; WDF2; ZFYVE22"
                     /coded_by="XM_011534915.3:420..1355"
                     /db_xref="GeneID:115825"
                     /db_xref="HGNC:HGNC:20482"
                     /db_xref="MIM:610418"
ORIGIN      
        1 mqclefilse dynkmtpvkn yqahqsrvtm ilfvlelewv lstgqdkqfa whcsesgqrl
       61 ggyrtsavas glqfdvetrh vfigdhsgqv tilkleqenc tlvttfrght ggvtalcwdp
      121 vqrvlfsgss dhsvimwdig grkgtaielq ghndrvqals yaqhtrqlis cggdggivvw
      181 nmdverqetp ewldsdscqk cdqpffwnfk qmwdskkigl rqhhcrkcgk avcgkcsskr
      241 ssiplmgfef evrvcdsche aitdeerapt atfhdskhni vhvhfdatrg wlltsgtdkv
      301 iklwdmtpvv s
//
LOCUS       XP_047286045             290 aa            linear   PRI 05-AUG-2025
DEFINITION  WD repeat and FYVE domain-containing protein 2 isoform X4 [Homo
            sapiens].
ACCESSION   XP_047286045
VERSION     XP_047286045.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430089.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..290
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..290
                     /product="WD repeat and FYVE domain-containing protein 2
                     isoform X4"
                     /calculated_mol_wt=32316
     Region          16..272
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Site            order(23,41,45,51,53,65,85,89,95,100,112..113,130,135,
                     141..142,171,176,182..183,197..198,216,220,226..227,
                     240..241,258,263,269..270)
                     /site_type="active"
                     /note="structural tetrad [active]"
                     /db_xref="CDD:238121"
     Region          27..64
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          72..132
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          202..239
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..290
                     /gene="WDFY2"
                     /gene_synonym="PROF; WDF2; ZFYVE22"
                     /coded_by="XM_047430089.1:227..1099"
                     /db_xref="GeneID:115825"
                     /db_xref="HGNC:HGNC:20482"
                     /db_xref="MIM:610418"
ORIGIN      
        1 maaeiqpkpl trkpillqrm egsqevvnma vivpkeegvi svsedrtvrv wlkrdsgqyw
       61 psvyhampsp cscmsfnpet rrlsigldng tisefilsed ynkmtpvkny qahqsrvtmi
      121 lfvlelewvl stgqdkqfaw hcsesgqrlg gyrtsavasg lqfdvetrhv figdhsgqvt
      181 ilkleqenct lvttfrghtg gvtalcwdpv qrvlfsgssd hsvimwdigg rkgtaielqg
      241 hndrvqalsy aqhtrqlisc ggdggivvwn mdverqeplw scfvvmisav
//
LOCUS       XP_047286047             201 aa            linear   PRI 05-AUG-2025
DEFINITION  WD repeat and FYVE domain-containing protein 2 isoform X5 [Homo
            sapiens].
ACCESSION   XP_047286047
VERSION     XP_047286047.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430091.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..201
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..201
                     /product="WD repeat and FYVE domain-containing protein 2
                     isoform X5"
                     /calculated_mol_wt=22364
     Region          <11..183
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          28..61
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          113..150
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..201
                     /gene="WDFY2"
                     /gene_synonym="PROF; WDF2; ZFYVE22"
                     /coded_by="XM_047430091.1:57..662"
                     /db_xref="GeneID:115825"
                     /db_xref="HGNC:HGNC:20482"
                     /db_xref="MIM:610418"
ORIGIN      
        1 mqclefilse dynkmtpvkn yqahqsrvtm ilfvlelewv lstgqdkqfa whcsesgqrl
       61 ggyrtsavas glqfdvetrh vfigdhsgqv tilkleqenc tlvttfrght ggvtalcwdp
      121 vqrvlfsgss dhsvimwdig grkgtaielq ghndrvqals yaqhtrqlis cggdggivvw
      181 nmdverqepl wscfvvmisa v
//
LOCUS       XP_016875876             178 aa            linear   PRI 05-AUG-2025
DEFINITION  testis-expressed protein 29 isoform X1 [Homo sapiens].
ACCESSION   XP_016875876
VERSION     XP_016875876.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020387.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XP_016875876.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..178
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..178
                     /product="testis-expressed protein 29 isoform X1"
                     /calculated_mol_wt=19350
     Region          40..115
                     /region_name="TEX29"
                     /note="Testis-expressed sequence 29 protein; pfam15839"
                     /db_xref="CDD:464904"
     CDS             1..178
                     /gene="TEX29"
                     /gene_synonym="bA474D23.1; C13orf16"
                     /coded_by="XM_017020387.2:27..563"
                     /db_xref="GeneID:121793"
                     /db_xref="HGNC:HGNC:20370"
ORIGIN      
        1 mpaicqgrqe vtvqaqcarp lhlsaaamey vlevknsprh llkqftvcdv plydicdynv
       61 srdrcqelgc cfyegvcykk avpiyihvfs aliviiagaf vitiiyrviq esrkekaipv
      121 dvalpqksse kaelassssk lglkpaspgp psagpsmksd edkddvtgti teaeeted
//
LOCUS       XP_016875878             383 aa            linear   PRI 05-AUG-2025
DEFINITION  relaxin receptor 2 isoform X1 [Homo sapiens].
ACCESSION   XP_016875878
VERSION     XP_016875878.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020389.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..383
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..383
                     /product="relaxin receptor 2 isoform X1"
                     /calculated_mol_wt=43703
     Region          45..80
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(50,59,70..71)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(63,66,70,76..77)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            73..77
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          <138..>370
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          139..162
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          163..186
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          187..210
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          211..234
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          235..258
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          259..282
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          283..306
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          307..330
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          331..354
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          355..374
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     CDS             1..383
                     /gene="RXFP2"
                     /gene_synonym="GPR106; GREAT; INSL3R; LGR8; LGR8.1;
                     RXFPR2"
                     /coded_by="XM_017020389.2:88..1239"
                     /db_xref="GeneID:122042"
                     /db_xref="HGNC:HGNC:17318"
                     /db_xref="MIM:606655"
ORIGIN      
        1 mivflvfkhl fslrlitmff llhfivlinv kdfaltqgsm itpscqkgyf pcgnltkclp
       61 rafhcdgkdd cgngadeenc gdtsgwatif gtvhgnansv altqecflkq ypqccdcket
      121 elecvngdlk svpmisnnvt llslkknkih slpdkvfiky tklkkiflqh ncirhisrka
      181 ffglcnlqil ylnhncittl rpgifkdlhq ltwlilddnp itrisqrlft glnslfflsm
      241 vnnylealpk qmcaqmpqln wvdlegnrik yltnstflsc dsltvlflpr nqigfvpekt
      301 fsslknlgel dlssntitel sphlfkdlkl lqklnlssnp lmylhknqfe slkqlqsldl
      361 erieipnint rmfqpmknls hmc
//
LOCUS       XP_011533221             288 aa            linear   PRI 05-AUG-2025
DEFINITION  testis-expressed protein 26 isoform X1 [Homo sapiens].
ACCESSION   XP_011533221
VERSION     XP_011533221.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534919.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..288
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..288
                     /product="testis-expressed protein 26 isoform X1"
                     /calculated_mol_wt=33362
     CDS             1..288
                     /gene="TEX26"
                     /gene_synonym="C13orf26"
                     /coded_by="XM_011534919.4:61..927"
                     /db_xref="GeneID:122046"
                     /db_xref="HGNC:HGNC:28622"
ORIGIN      
        1 meqpgprapd pslchhnlqp ndpnwdsyat tmrtaftpkt gavpalirqn girrlgytys
       61 lsdpilnqtq ysdeytwksh skedliktet srgikshksh lnediflwtl phcqqtgtlk
      121 nclpwkipas mkevnkalsn qfisltkrdf vdrskaqkik ksshlslewk kllpqppdte
      181 frrnyqipak ipelqdfsfk ygcysslpva sqglvpsvlh sylrnqehtk kqttyqsdyd
      241 ktypdflmll nsftssqvke ylqslsykdr qiidrfirth cdtnkkkk
//
LOCUS       XP_011533223             273 aa            linear   PRI 05-AUG-2025
DEFINITION  testis-expressed protein 26 isoform X2 [Homo sapiens].
ACCESSION   XP_011533223
VERSION     XP_011533223.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534921.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..273
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..273
                     /product="testis-expressed protein 26 isoform X2"
                     /calculated_mol_wt=31003
     CDS             1..273
                     /gene="TEX26"
                     /gene_synonym="C13orf26"
                     /coded_by="XM_011534921.4:61..882"
                     /db_xref="GeneID:122046"
                     /db_xref="HGNC:HGNC:28622"
ORIGIN      
        1 meqpgprapd pslchhnlqp tddpnwdsya ttmrtaftpk tgavpalirq ngirrlgyty
       61 slsdpilnqt qysdeytwks hskedlikte tsrgikshks hlnediflwt lphcqqtgtl
      121 knclpwkipa smkevnkals nqfisltkrd fvdrskaqki kksshlslew kkllpqppdt
      181 efrrnyqipa kipelqdfsf kygcysslpv asqgldpdkg rpwkarlhqc rfpvdaghpt
      241 lkdnfaglll sagllnshln vyqrrcllcc tat
//
LOCUS       XP_047286050             257 aa            linear   PRI 05-AUG-2025
DEFINITION  testis-expressed protein 26 isoform X3 [Homo sapiens].
ACCESSION   XP_047286050
VERSION     XP_047286050.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430094.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..257
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..257
                     /product="testis-expressed protein 26 isoform X3"
                     /calculated_mol_wt=29890
     CDS             1..257
                     /gene="TEX26"
                     /gene_synonym="C13orf26"
                     /coded_by="XM_047430094.1:290..1063"
                     /db_xref="GeneID:122046"
                     /db_xref="HGNC:HGNC:28622"
ORIGIN      
        1 mrtaftpktg avpalirqng irrlgytysl sdpilnqtqy sdeytwkshs kedliktets
       61 rgikshkshl nediflwtlp hcqqtgtlkn clpwkipasm kevnkalsnq fisltkrdfv
      121 drskaqkikk sshlslewkk llpqppdtef rrnyqipaki pelqdfsfky gcysslpvas
      181 qglvpsvlhs ylrnqehtkk qttyqsdydk typdflmlln sftssqvkey lqslsykdrq
      241 iidrfirthc dtnkkkk
//
LOCUS       XP_011533226             257 aa            linear   PRI 05-AUG-2025
DEFINITION  testis-expressed protein 26 isoform X4 [Homo sapiens].
ACCESSION   XP_011533226
VERSION     XP_011533226.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534924.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..257
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..257
                     /product="testis-expressed protein 26 isoform X4"
                     /calculated_mol_wt=29030
     CDS             1..257
                     /gene="TEX26"
                     /gene_synonym="C13orf26"
                     /coded_by="XM_011534924.4:61..834"
                     /db_xref="GeneID:122046"
                     /db_xref="HGNC:HGNC:28622"
ORIGIN      
        1 meqpgprapd pslchhnlqp tddpnwdsya ttmrtaftpk tgavpalirq ngirrlgyty
       61 slsdpilnqt qysdeytwks hskedlikte tsrgikshks hlnediflwt lphcqqtgtl
      121 knclpwkipa smkevnkals nqfisltkrd fvdrskaqki kksshlslew kkllpqppdt
      181 efrrnyqipa kipelqdfsf kygcysslpv asqglvkafp gptntllrvq cqilspvwfl
      241 hlandplkgi pgagrcs
//
LOCUS       XP_011533227             235 aa            linear   PRI 05-AUG-2025
DEFINITION  testis-expressed protein 26 isoform X5 [Homo sapiens].
ACCESSION   XP_011533227
VERSION     XP_011533227.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534925.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..235
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..235
                     /product="testis-expressed protein 26 isoform X5"
                     /calculated_mol_wt=27030
     CDS             1..235
                     /gene="TEX26"
                     /gene_synonym="C13orf26"
                     /coded_by="XM_011534925.4:61..768"
                     /db_xref="GeneID:122046"
                     /db_xref="HGNC:HGNC:28622"
ORIGIN      
        1 meqpgprapd pslchhnlqp tddpnwdsya ttmrtaftpk tgavpalirq ngirrlgyty
       61 slsdpilnqt qysdeytwks hskedlikte tsrgikshks hlnediflwt lphcqqtgtl
      121 knclpwkipa smkevnkals nqfisltkrd fvdrskaqki kksshlslew kkllpqppdt
      181 efrrnyqipa kipelqdfsf kygcysslpv asqgldrqii drfirthcdt nkkkk
//
LOCUS       XP_011533228             176 aa            linear   PRI 05-AUG-2025
DEFINITION  testis-expressed protein 26 isoform X6 [Homo sapiens].
ACCESSION   XP_011533228
VERSION     XP_011533228.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534926.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..176
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..176
                     /product="testis-expressed protein 26 isoform X6"
                     /calculated_mol_wt=20239
     CDS             1..176
                     /gene="TEX26"
                     /gene_synonym="C13orf26"
                     /coded_by="XM_011534926.4:61..591"
                     /db_xref="GeneID:122046"
                     /db_xref="HGNC:HGNC:28622"
ORIGIN      
        1 meqpgprapd pslchhnlqp tddpnwdsya ttmrtaftpk tgavpalirq ngirrlgyty
       61 slsdpilnqt qysdeytwks hskedlikte tsrgikshks hlnediflwt lphcqqtgtl
      121 knclpwkipa smkevnkals nqfisltkrd fvdrskdrqi idrfirthcd tnkkkk
//
LOCUS       XP_011533229             172 aa            linear   PRI 05-AUG-2025
DEFINITION  testis-expressed protein 26 isoform X7 [Homo sapiens].
ACCESSION   XP_011533229
VERSION     XP_011533229.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534927.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..172
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..172
                     /product="testis-expressed protein 26 isoform X7"
                     /calculated_mol_wt=19619
     CDS             1..172
                     /gene="TEX26"
                     /gene_synonym="C13orf26"
                     /coded_by="XM_011534927.4:61..579"
                     /db_xref="GeneID:122046"
                     /db_xref="HGNC:HGNC:28622"
ORIGIN      
        1 meqpgprapd pslchhnlqp tddpnwdsya ttmrtaftpk tgavpalirq ngirrlgyty
       61 slsdpilnqt qysdeytwks hskedlikte tsrgikshks hlnediflwt lphcqqtgtl
      121 knclpwkipa smkevnkals nqfisltkrd fvdrskeild arrhlekcve gk
//
LOCUS       XP_011535768             245 aa            linear   PRI 05-AUG-2025
DEFINITION  sperm acrosome-associated protein 7 isoform X1 [Homo sapiens].
ACCESSION   XP_011535768
VERSION     XP_011535768.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537466.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XP_011535768.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..245
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..245
                     /product="sperm acrosome-associated protein 7 isoform X1"
                     /calculated_mol_wt=26434
     Region          19..125
                     /region_name="SPACA7"
                     /note="Sperm acrosome-associated protein 7; pfam15307"
                     /db_xref="CDD:434617"
     CDS             1..245
                     /gene="SPACA7"
                     /gene_synonym="C13orf28"
                     /coded_by="XM_011537466.2:32..769"
                     /db_xref="GeneID:122258"
                     /db_xref="HGNC:HGNC:29575"
ORIGIN      
        1 mavsqgdgtl cfvlllccwq etelrprtvi pgspteipfs skqedmsell deilvqeild
       61 lnkttpsemp stastlstpl hagidenyqa ggsenyhell enlqfspgie vkisndeana
      121 nanlhgdpse nyrgpqvspg seksvsskad gislhtelpg vgrgvipals wppqlapmlg
      181 ltqsptaaqt stvpeliqek nskntqyenl sildqilqni grssgnifhk eqqrtsaqrr
      241 sqgsq
//
LOCUS       XP_011535769             226 aa            linear   PRI 05-AUG-2025
DEFINITION  sperm acrosome-associated protein 7 isoform X2 [Homo sapiens].
ACCESSION   XP_011535769
VERSION     XP_011535769.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537467.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XP_011535769.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..226
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..226
                     /product="sperm acrosome-associated protein 7 isoform X2"
                     /calculated_mol_wt=24357
     Region          19..106
                     /region_name="SPACA7"
                     /note="Sperm acrosome-associated protein 7; pfam15307"
                     /db_xref="CDD:434617"
     CDS             1..226
                     /gene="SPACA7"
                     /gene_synonym="C13orf28"
                     /coded_by="XM_011537467.3:32..712"
                     /db_xref="GeneID:122258"
                     /db_xref="HGNC:HGNC:29575"
ORIGIN      
        1 mavsqgdgtl cfvlllccwq etelrprtvi pdeilvqeil dlnkttpsem pstastlstp
       61 lhagidenyq aggsenyhel lenlqfspgi evkisndean ananlhgdps enyrgpqvsp
      121 gseksvsska dgislhtelp gvgrgvipal swppqlapml gltqsptaaq tstvpeliqe
      181 knskntqyen lsildqilqn igrssgnifh keqqrtsaqr rsqgsq
//
LOCUS       XP_011535770             231 aa            linear   PRI 05-AUG-2025
DEFINITION  sperm acrosome-associated protein 7 isoform X3 [Homo sapiens].
ACCESSION   XP_011535770
VERSION     XP_011535770.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537468.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..231
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..231
                     /product="sperm acrosome-associated protein 7 isoform X3"
                     /calculated_mol_wt=24905
     Region          8..111
                     /region_name="SPACA7"
                     /note="Sperm acrosome-associated protein 7; pfam15307"
                     /db_xref="CDD:434617"
     CDS             1..231
                     /gene="SPACA7"
                     /gene_synonym="C13orf28"
                     /coded_by="XM_011537468.3:163..858"
                     /db_xref="GeneID:122258"
                     /db_xref="HGNC:HGNC:29575"
ORIGIN      
        1 mtffthlwdg dpvsqvagsp teipfsskqe dmselldeil vqeildlnkt tpsempstas
       61 tlstplhagi denyqaggse nyhellenlq fspgievkis ndeanananl hgdpsenyrg
      121 pqvspgseks vsskadgisl htelpgvgrg vipalswppq lapmlgltqs ptaaqtstvp
      181 eliqeknskn tqyenlsild qilqnigrss gnifhkeqqr tsaqrrsqgs q
//
LOCUS       XP_011535773             200 aa            linear   PRI 05-AUG-2025
DEFINITION  sperm acrosome-associated protein 7 isoform X4 [Homo sapiens].
ACCESSION   XP_011535773
VERSION     XP_011535773.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537471.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..200
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..200
                     /product="sperm acrosome-associated protein 7 isoform X4"
                     /calculated_mol_wt=21469
     Region          <1..80
                     /region_name="SPACA7"
                     /note="Sperm acrosome-associated protein 7; pfam15307"
                     /db_xref="CDD:434617"
     CDS             1..200
                     /gene="SPACA7"
                     /gene_synonym="C13orf28"
                     /coded_by="XM_011537471.3:328..930"
                     /db_xref="GeneID:122258"
                     /db_xref="HGNC:HGNC:29575"
ORIGIN      
        1 mselldeilv qeildlnktt psempstast lstplhagid enyqaggsen yhellenlqf
       61 spgievkisn deanananlh gdpsenyrgp qvspgseksv sskadgislh telpgvgrgv
      121 ipalswppql apmlgltqsp taaqtstvpe liqeknsknt qyenlsildq ilqnigrssg
      181 nifhkeqqrt saqrrsqgsq
//
LOCUS       XP_011535774             179 aa            linear   PRI 05-AUG-2025
DEFINITION  sperm acrosome-associated protein 7 isoform X5 [Homo sapiens].
ACCESSION   XP_011535774
VERSION     XP_011535774.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537472.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XP_011535774.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..179
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..179
                     /product="sperm acrosome-associated protein 7 isoform X5"
                     /calculated_mol_wt=19237
     Region          19..81
                     /region_name="SPACA7"
                     /note="Sperm acrosome-associated protein 7; pfam15307"
                     /db_xref="CDD:434617"
     CDS             1..179
                     /gene="SPACA7"
                     /gene_synonym="C13orf28"
                     /coded_by="XM_011537472.3:32..571"
                     /db_xref="GeneID:122258"
                     /db_xref="HGNC:HGNC:29575"
ORIGIN      
        1 mavsqgdgtl cfvlllccwq etelrprtvi pgspteipfs skqedmsell eanananlhg
       61 dpsenyrgpq vspgseksvs skadgislht elpgvgrgvi palswppqla pmlgltqspt
      121 aaqtstvpel iqeknskntq yenlsildqi lqnigrssgn ifhkeqqrts aqrrsqgsq
//
LOCUS       XP_024305086             176 aa            linear   PRI 05-AUG-2025
DEFINITION  sperm acrosome-associated protein 7 isoform X6 [Homo sapiens].
ACCESSION   XP_024305086
VERSION     XP_024305086.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449318.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XP_024305086.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..176
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..176
                     /product="sperm acrosome-associated protein 7 isoform X6"
                     /calculated_mol_wt=19257
     Region          19..106
                     /region_name="SPACA7"
                     /note="Sperm acrosome-associated protein 7; pfam15307"
                     /db_xref="CDD:434617"
     CDS             1..176
                     /gene="SPACA7"
                     /gene_synonym="C13orf28"
                     /coded_by="XM_024449318.2:32..562"
                     /db_xref="GeneID:122258"
                     /db_xref="HGNC:HGNC:29575"
ORIGIN      
        1 mavsqgdgtl cfvlllccwq etelrprtvi pdeilvqeil dlnkttpsem pstastlstp
       61 lhagidenyq aggsenyhel lenlqfspgi evkisndean ananlhgdps enyrgpqvsp
      121 gseksvsske knskntqyen lsildqilqn igrssgnifh keqqrtsaqr rsqgsq
//
LOCUS       XP_016875880             160 aa            linear   PRI 05-AUG-2025
DEFINITION  sperm acrosome-associated protein 7 isoform X7 [Homo sapiens].
ACCESSION   XP_016875880
VERSION     XP_016875880.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020391.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XP_016875880.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..160
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..160
                     /product="sperm acrosome-associated protein 7 isoform X7"
                     /calculated_mol_wt=17159
     CDS             1..160
                     /gene="SPACA7"
                     /gene_synonym="C13orf28"
                     /coded_by="XM_017020391.2:32..514"
                     /db_xref="GeneID:122258"
                     /db_xref="HGNC:HGNC:29575"
ORIGIN      
        1 mavsqgdgtl cfvlllccwq etelrprtvi peanananlh gdpsenyrgp qvspgseksv
       61 sskadgislh telpgvgrgv ipalswppql apmlgltqsp taaqtstvpe liqeknsknt
      121 qyenlsildq ilqnigrssg nifhkeqqrt saqrrsqgsq
//
LOCUS       XP_016875881             165 aa            linear   PRI 05-AUG-2025
DEFINITION  sperm acrosome-associated protein 7 isoform X8 [Homo sapiens].
ACCESSION   XP_016875881
VERSION     XP_016875881.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020392.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..165
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..165
                     /product="sperm acrosome-associated protein 7 isoform X8"
                     /calculated_mol_wt=17708
     Region          8..>37
                     /region_name="SPACA7"
                     /note="Sperm acrosome-associated protein 7; pfam15307"
                     /db_xref="CDD:434617"
     CDS             1..165
                     /gene="SPACA7"
                     /gene_synonym="C13orf28"
                     /coded_by="XM_017020392.2:163..660"
                     /db_xref="GeneID:122258"
                     /db_xref="HGNC:HGNC:29575"
ORIGIN      
        1 mtffthlwdg dpvsqvagsp teipfsskqe dmselleana nanlhgdpse nyrgpqvspg
       61 seksvsskad gislhtelpg vgrgvipals wppqlapmlg ltqsptaaqt stvpeliqek
      121 nskntqyenl sildqilqni grssgnifhk eqqrtsaqrr sqgsq
//
LOCUS       XP_016875882             414 aa            linear   PRI 05-AUG-2025
DEFINITION  carboxypeptidase B2 isoform X1 [Homo sapiens].
ACCESSION   XP_016875882
VERSION     XP_016875882.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020393.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..414
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..414
                     /product="carboxypeptidase B2 isoform X1"
                     /calculated_mol_wt=47044
     Region          24..96
                     /region_name="Propep_M14"
                     /note="Carboxypeptidase activation peptide; pfam02244"
                     /db_xref="CDD:460505"
     Region          110..411
                     /region_name="M14_CPB2"
                     /note="Peptidase M14 carboxypeptidase subfamily A/B-like;
                     Carboxypeptidase B2 subgroup; cd06246"
                     /db_xref="CDD:349465"
     Site            order(172,175,230,247..248,301..302,308,376)
                     /site_type="active"
                     /db_xref="CDD:349465"
     CDS             1..414
                     /gene="CPB2"
                     /gene_synonym="CPU; PCPB; TAFI"
                     /coded_by="XM_017020393.3:130..1374"
                     /db_xref="GeneID:1361"
                     /db_xref="HGNC:HGNC:2300"
                     /db_xref="MIM:603101"
ORIGIN      
        1 maspvpvesl eaglacgqvl aalprtsrqv qvlqnlttty eivlwqpvta dlivkkkqvh
       61 ffvnasdvdn vkahlnvsgi pcsvlladve dliqqqisnd tvsprasasy yeqyhslnei
      121 yswiefiter hpdmltkihi gssfekyply vlkvsgkeqa aknaiwidcg iharewispa
      181 fclwfighit qfygiigqyt nllrlvdfyv mpvvnvdgyd yswkknrmwr knrsfyannh
      241 cigtdlnrnf askhwceega sssscsetyc glypesepev kavasflrrn inqikayism
      301 hsysqhivfp ysytrskskd heelslvase avraiekisk ntrythghgs etlylapggg
      361 ddwiydlgik ysftielrdt gtygfllper yikptcreaf aavskiawhv irnv
//
LOCUS       XP_047286055             430 aa            linear   PRI 05-AUG-2025
DEFINITION  purine nucleoside phosphorylase LACC1 isoform X1 [Homo sapiens].
ACCESSION   XP_047286055
VERSION     XP_047286055.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430099.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..430
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..430
                     /product="purine nucleoside phosphorylase LACC1 isoform
                     X1"
                     /calculated_mol_wt=47649
     Region          195..426
                     /region_name="Cu-oxidase_4"
                     /note="Multi-copper polyphenol oxidoreductase laccase;
                     pfam02578"
                     /db_xref="CDD:460601"
     CDS             1..430
                     /gene="LACC1"
                     /gene_synonym="C13orf31; FAMIN; JUVAR"
                     /coded_by="XM_047430099.1:410..1702"
                     /db_xref="GeneID:144811"
                     /db_xref="HGNC:HGNC:26789"
                     /db_xref="MIM:613409"
ORIGIN      
        1 maeavlidlf glklnsqknc hqtllktlna vqyhhaakak flcimccsni syerdgeqdn
       61 ceietsngls alleefeivs cpsmaatlyt ikqkideknl ssikvivprh rktlmkafid
      121 qlftdvynfe fedlqvtfrg glfkqsiein vitaqelrgi qneietflrs lpalrgklti
      181 itsslipdif ihgfttrtgg isyiptlssf nlfssskrrd pkvvvqenlr rlanaagfnv
      241 ekfyrikthh sndiwimgrk epdsydgitt nqrgvtiaal gadcipivfa dpvkkacgva
      301 hagwkgtllg vamatvnami aeygcsledi vvvlgpsvgp ccftlpresa eafhnlhpac
      361 vqlfdspnpc idirkatril leqggilpqn iqdqnqdlnl ctschpdkff shvrdglnfg
      421 tqigfisike
//
LOCUS       XP_047286056             430 aa            linear   PRI 05-AUG-2025
DEFINITION  purine nucleoside phosphorylase LACC1 isoform X1 [Homo sapiens].
ACCESSION   XP_047286056
VERSION     XP_047286056.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430100.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..430
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..430
                     /product="purine nucleoside phosphorylase LACC1 isoform
                     X1"
                     /calculated_mol_wt=47649
     Region          195..426
                     /region_name="Cu-oxidase_4"
                     /note="Multi-copper polyphenol oxidoreductase laccase;
                     pfam02578"
                     /db_xref="CDD:460601"
     CDS             1..430
                     /gene="LACC1"
                     /gene_synonym="C13orf31; FAMIN; JUVAR"
                     /coded_by="XM_047430100.1:113..1405"
                     /db_xref="GeneID:144811"
                     /db_xref="HGNC:HGNC:26789"
                     /db_xref="MIM:613409"
ORIGIN      
        1 maeavlidlf glklnsqknc hqtllktlna vqyhhaakak flcimccsni syerdgeqdn
       61 ceietsngls alleefeivs cpsmaatlyt ikqkideknl ssikvivprh rktlmkafid
      121 qlftdvynfe fedlqvtfrg glfkqsiein vitaqelrgi qneietflrs lpalrgklti
      181 itsslipdif ihgfttrtgg isyiptlssf nlfssskrrd pkvvvqenlr rlanaagfnv
      241 ekfyrikthh sndiwimgrk epdsydgitt nqrgvtiaal gadcipivfa dpvkkacgva
      301 hagwkgtllg vamatvnami aeygcsledi vvvlgpsvgp ccftlpresa eafhnlhpac
      361 vqlfdspnpc idirkatril leqggilpqn iqdqnqdlnl ctschpdkff shvrdglnfg
      421 tqigfisike
//
LOCUS       XP_047286057             428 aa            linear   PRI 05-AUG-2025
DEFINITION  purine nucleoside phosphorylase LACC1 isoform X2 [Homo sapiens].
ACCESSION   XP_047286057
VERSION     XP_047286057.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430101.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..428
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..428
                     /product="purine nucleoside phosphorylase LACC1 isoform
                     X2"
                     /calculated_mol_wt=47653
     Region          195..378
                     /region_name="Cu-oxidase_4"
                     /note="Multi-copper polyphenol oxidoreductase laccase;
                     pfam02578"
                     /db_xref="CDD:460601"
     CDS             1..428
                     /gene="LACC1"
                     /gene_synonym="C13orf31; FAMIN; JUVAR"
                     /coded_by="XM_047430101.1:410..1696"
                     /db_xref="GeneID:144811"
                     /db_xref="HGNC:HGNC:26789"
                     /db_xref="MIM:613409"
ORIGIN      
        1 maeavlidlf glklnsqknc hqtllktlna vqyhhaakak flcimccsni syerdgeqdn
       61 ceietsngls alleefeivs cpsmaatlyt ikqkideknl ssikvivprh rktlmkafid
      121 qlftdvynfe fedlqvtfrg glfkqsiein vitaqelrgi qneietflrs lpalrgklti
      181 itsslipdif ihgfttrtgg isyiptlssf nlfssskrrd pkvvvqenlr rlanaagfnv
      241 ekfyrikthh sndiwimgrk epdsydgitt nqrgvtiaal gadcipivfa dpvkkacgva
      301 hagwkgtllg vamatvnami aeygcsledi vvvlgpsvgp ccftlpresa eafhnlhpac
      361 vqlfdspnpc idirkatryl tgflyncflp pskltarekf scliylkpng lqwiihllgi
      421 flllfkak
//
LOCUS       XP_047286058             428 aa            linear   PRI 05-AUG-2025
DEFINITION  purine nucleoside phosphorylase LACC1 isoform X2 [Homo sapiens].
ACCESSION   XP_047286058
VERSION     XP_047286058.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430102.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..428
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..428
                     /product="purine nucleoside phosphorylase LACC1 isoform
                     X2"
                     /calculated_mol_wt=47653
     Region          195..378
                     /region_name="Cu-oxidase_4"
                     /note="Multi-copper polyphenol oxidoreductase laccase;
                     pfam02578"
                     /db_xref="CDD:460601"
     CDS             1..428
                     /gene="LACC1"
                     /gene_synonym="C13orf31; FAMIN; JUVAR"
                     /coded_by="XM_047430102.1:796..2082"
                     /db_xref="GeneID:144811"
                     /db_xref="HGNC:HGNC:26789"
                     /db_xref="MIM:613409"
ORIGIN      
        1 maeavlidlf glklnsqknc hqtllktlna vqyhhaakak flcimccsni syerdgeqdn
       61 ceietsngls alleefeivs cpsmaatlyt ikqkideknl ssikvivprh rktlmkafid
      121 qlftdvynfe fedlqvtfrg glfkqsiein vitaqelrgi qneietflrs lpalrgklti
      181 itsslipdif ihgfttrtgg isyiptlssf nlfssskrrd pkvvvqenlr rlanaagfnv
      241 ekfyrikthh sndiwimgrk epdsydgitt nqrgvtiaal gadcipivfa dpvkkacgva
      301 hagwkgtllg vamatvnami aeygcsledi vvvlgpsvgp ccftlpresa eafhnlhpac
      361 vqlfdspnpc idirkatryl tgflyncflp pskltarekf scliylkpng lqwiihllgi
      421 flllfkak
//
LOCUS       XP_047286059             428 aa            linear   PRI 05-AUG-2025
DEFINITION  purine nucleoside phosphorylase LACC1 isoform X2 [Homo sapiens].
ACCESSION   XP_047286059
VERSION     XP_047286059.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430103.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..428
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..428
                     /product="purine nucleoside phosphorylase LACC1 isoform
                     X2"
                     /calculated_mol_wt=47653
     Region          195..378
                     /region_name="Cu-oxidase_4"
                     /note="Multi-copper polyphenol oxidoreductase laccase;
                     pfam02578"
                     /db_xref="CDD:460601"
     CDS             1..428
                     /gene="LACC1"
                     /gene_synonym="C13orf31; FAMIN; JUVAR"
                     /coded_by="XM_047430103.1:384..1670"
                     /db_xref="GeneID:144811"
                     /db_xref="HGNC:HGNC:26789"
                     /db_xref="MIM:613409"
ORIGIN      
        1 maeavlidlf glklnsqknc hqtllktlna vqyhhaakak flcimccsni syerdgeqdn
       61 ceietsngls alleefeivs cpsmaatlyt ikqkideknl ssikvivprh rktlmkafid
      121 qlftdvynfe fedlqvtfrg glfkqsiein vitaqelrgi qneietflrs lpalrgklti
      181 itsslipdif ihgfttrtgg isyiptlssf nlfssskrrd pkvvvqenlr rlanaagfnv
      241 ekfyrikthh sndiwimgrk epdsydgitt nqrgvtiaal gadcipivfa dpvkkacgva
      301 hagwkgtllg vamatvnami aeygcsledi vvvlgpsvgp ccftlpresa eafhnlhpac
      361 vqlfdspnpc idirkatryl tgflyncflp pskltarekf scliylkpng lqwiihllgi
      421 flllfkak
//
LOCUS       XP_047286060             428 aa            linear   PRI 05-AUG-2025
DEFINITION  purine nucleoside phosphorylase LACC1 isoform X2 [Homo sapiens].
ACCESSION   XP_047286060
VERSION     XP_047286060.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430104.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..428
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..428
                     /product="purine nucleoside phosphorylase LACC1 isoform
                     X2"
                     /calculated_mol_wt=47653
     Region          195..378
                     /region_name="Cu-oxidase_4"
                     /note="Multi-copper polyphenol oxidoreductase laccase;
                     pfam02578"
                     /db_xref="CDD:460601"
     CDS             1..428
                     /gene="LACC1"
                     /gene_synonym="C13orf31; FAMIN; JUVAR"
                     /coded_by="XM_047430104.1:592..1878"
                     /db_xref="GeneID:144811"
                     /db_xref="HGNC:HGNC:26789"
                     /db_xref="MIM:613409"
ORIGIN      
        1 maeavlidlf glklnsqknc hqtllktlna vqyhhaakak flcimccsni syerdgeqdn
       61 ceietsngls alleefeivs cpsmaatlyt ikqkideknl ssikvivprh rktlmkafid
      121 qlftdvynfe fedlqvtfrg glfkqsiein vitaqelrgi qneietflrs lpalrgklti
      181 itsslipdif ihgfttrtgg isyiptlssf nlfssskrrd pkvvvqenlr rlanaagfnv
      241 ekfyrikthh sndiwimgrk epdsydgitt nqrgvtiaal gadcipivfa dpvkkacgva
      301 hagwkgtllg vamatvnami aeygcsledi vvvlgpsvgp ccftlpresa eafhnlhpac
      361 vqlfdspnpc idirkatryl tgflyncflp pskltarekf scliylkpng lqwiihllgi
      421 flllfkak
//
LOCUS       XP_047286061             428 aa            linear   PRI 05-AUG-2025
DEFINITION  purine nucleoside phosphorylase LACC1 isoform X2 [Homo sapiens].
ACCESSION   XP_047286061
VERSION     XP_047286061.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430105.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..428
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..428
                     /product="purine nucleoside phosphorylase LACC1 isoform
                     X2"
                     /calculated_mol_wt=47653
     Region          195..378
                     /region_name="Cu-oxidase_4"
                     /note="Multi-copper polyphenol oxidoreductase laccase;
                     pfam02578"
                     /db_xref="CDD:460601"
     CDS             1..428
                     /gene="LACC1"
                     /gene_synonym="C13orf31; FAMIN; JUVAR"
                     /coded_by="XM_047430105.1:113..1399"
                     /db_xref="GeneID:144811"
                     /db_xref="HGNC:HGNC:26789"
                     /db_xref="MIM:613409"
ORIGIN      
        1 maeavlidlf glklnsqknc hqtllktlna vqyhhaakak flcimccsni syerdgeqdn
       61 ceietsngls alleefeivs cpsmaatlyt ikqkideknl ssikvivprh rktlmkafid
      121 qlftdvynfe fedlqvtfrg glfkqsiein vitaqelrgi qneietflrs lpalrgklti
      181 itsslipdif ihgfttrtgg isyiptlssf nlfssskrrd pkvvvqenlr rlanaagfnv
      241 ekfyrikthh sndiwimgrk epdsydgitt nqrgvtiaal gadcipivfa dpvkkacgva
      301 hagwkgtllg vamatvnami aeygcsledi vvvlgpsvgp ccftlpresa eafhnlhpac
      361 vqlfdspnpc idirkatryl tgflyncflp pskltarekf scliylkpng lqwiihllgi
      421 flllfkak
//
LOCUS       XP_011533237             318 aa            linear   PRI 05-AUG-2025
DEFINITION  purine nucleoside phosphorylase LACC1 isoform X3 [Homo sapiens].
ACCESSION   XP_011533237
VERSION     XP_011533237.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534935.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..318
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..318
                     /product="purine nucleoside phosphorylase LACC1 isoform
                     X3"
                     /calculated_mol_wt=35486
     Region          195..>303
                     /region_name="Cu-oxidase_4"
                     /note="Multi-copper polyphenol oxidoreductase laccase;
                     pfam02578"
                     /db_xref="CDD:460601"
     CDS             1..318
                     /gene="LACC1"
                     /gene_synonym="C13orf31; FAMIN; JUVAR"
                     /coded_by="XM_011534935.4:410..1366"
                     /db_xref="GeneID:144811"
                     /db_xref="HGNC:HGNC:26789"
                     /db_xref="MIM:613409"
ORIGIN      
        1 maeavlidlf glklnsqknc hqtllktlna vqyhhaakak flcimccsni syerdgeqdn
       61 ceietsngls alleefeivs cpsmaatlyt ikqkideknl ssikvivprh rktlmkafid
      121 qlftdvynfe fedlqvtfrg glfkqsiein vitaqelrgi qneietflrs lpalrgklti
      181 itsslipdif ihgfttrtgg isyiptlssf nlfssskrrd pkvvvqenlr rlanaagfnv
      241 ekfyrikthh sndiwimgrk epdsydgitt nqrgvtiaal gadcipivfa dpvkkacgva
      301 hagsktfsln iskikqsk
//
LOCUS       XP_047286062             318 aa            linear   PRI 05-AUG-2025
DEFINITION  purine nucleoside phosphorylase LACC1 isoform X3 [Homo sapiens].
ACCESSION   XP_047286062
VERSION     XP_047286062.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430106.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..318
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..318
                     /product="purine nucleoside phosphorylase LACC1 isoform
                     X3"
                     /calculated_mol_wt=35486
     Region          195..>303
                     /region_name="Cu-oxidase_4"
                     /note="Multi-copper polyphenol oxidoreductase laccase;
                     pfam02578"
                     /db_xref="CDD:460601"
     CDS             1..318
                     /gene="LACC1"
                     /gene_synonym="C13orf31; FAMIN; JUVAR"
                     /coded_by="XM_047430106.1:796..1752"
                     /db_xref="GeneID:144811"
                     /db_xref="HGNC:HGNC:26789"
                     /db_xref="MIM:613409"
ORIGIN      
        1 maeavlidlf glklnsqknc hqtllktlna vqyhhaakak flcimccsni syerdgeqdn
       61 ceietsngls alleefeivs cpsmaatlyt ikqkideknl ssikvivprh rktlmkafid
      121 qlftdvynfe fedlqvtfrg glfkqsiein vitaqelrgi qneietflrs lpalrgklti
      181 itsslipdif ihgfttrtgg isyiptlssf nlfssskrrd pkvvvqenlr rlanaagfnv
      241 ekfyrikthh sndiwimgrk epdsydgitt nqrgvtiaal gadcipivfa dpvkkacgva
      301 hagsktfsln iskikqsk
//
LOCUS       XP_047286063             318 aa            linear   PRI 05-AUG-2025
DEFINITION  purine nucleoside phosphorylase LACC1 isoform X3 [Homo sapiens].
ACCESSION   XP_047286063
VERSION     XP_047286063.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430107.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..318
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..318
                     /product="purine nucleoside phosphorylase LACC1 isoform
                     X3"
                     /calculated_mol_wt=35486
     Region          195..>303
                     /region_name="Cu-oxidase_4"
                     /note="Multi-copper polyphenol oxidoreductase laccase;
                     pfam02578"
                     /db_xref="CDD:460601"
     CDS             1..318
                     /gene="LACC1"
                     /gene_synonym="C13orf31; FAMIN; JUVAR"
                     /coded_by="XM_047430107.1:384..1340"
                     /db_xref="GeneID:144811"
                     /db_xref="HGNC:HGNC:26789"
                     /db_xref="MIM:613409"
ORIGIN      
        1 maeavlidlf glklnsqknc hqtllktlna vqyhhaakak flcimccsni syerdgeqdn
       61 ceietsngls alleefeivs cpsmaatlyt ikqkideknl ssikvivprh rktlmkafid
      121 qlftdvynfe fedlqvtfrg glfkqsiein vitaqelrgi qneietflrs lpalrgklti
      181 itsslipdif ihgfttrtgg isyiptlssf nlfssskrrd pkvvvqenlr rlanaagfnv
      241 ekfyrikthh sndiwimgrk epdsydgitt nqrgvtiaal gadcipivfa dpvkkacgva
      301 hagsktfsln iskikqsk
//
LOCUS       XP_024305087             318 aa            linear   PRI 05-AUG-2025
DEFINITION  purine nucleoside phosphorylase LACC1 isoform X3 [Homo sapiens].
ACCESSION   XP_024305087
VERSION     XP_024305087.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449319.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..318
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..318
                     /product="purine nucleoside phosphorylase LACC1 isoform
                     X3"
                     /calculated_mol_wt=35486
     Region          195..>303
                     /region_name="Cu-oxidase_4"
                     /note="Multi-copper polyphenol oxidoreductase laccase;
                     pfam02578"
                     /db_xref="CDD:460601"
     CDS             1..318
                     /gene="LACC1"
                     /gene_synonym="C13orf31; FAMIN; JUVAR"
                     /coded_by="XM_024449319.2:592..1548"
                     /db_xref="GeneID:144811"
                     /db_xref="HGNC:HGNC:26789"
                     /db_xref="MIM:613409"
ORIGIN      
        1 maeavlidlf glklnsqknc hqtllktlna vqyhhaakak flcimccsni syerdgeqdn
       61 ceietsngls alleefeivs cpsmaatlyt ikqkideknl ssikvivprh rktlmkafid
      121 qlftdvynfe fedlqvtfrg glfkqsiein vitaqelrgi qneietflrs lpalrgklti
      181 itsslipdif ihgfttrtgg isyiptlssf nlfssskrrd pkvvvqenlr rlanaagfnv
      241 ekfyrikthh sndiwimgrk epdsydgitt nqrgvtiaal gadcipivfa dpvkkacgva
      301 hagsktfsln iskikqsk
//
LOCUS       XP_047286064             318 aa            linear   PRI 05-AUG-2025
DEFINITION  purine nucleoside phosphorylase LACC1 isoform X3 [Homo sapiens].
ACCESSION   XP_047286064
VERSION     XP_047286064.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430108.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..318
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..318
                     /product="purine nucleoside phosphorylase LACC1 isoform
                     X3"
                     /calculated_mol_wt=35486
     Region          195..>303
                     /region_name="Cu-oxidase_4"
                     /note="Multi-copper polyphenol oxidoreductase laccase;
                     pfam02578"
                     /db_xref="CDD:460601"
     CDS             1..318
                     /gene="LACC1"
                     /gene_synonym="C13orf31; FAMIN; JUVAR"
                     /coded_by="XM_047430108.1:206..1162"
                     /db_xref="GeneID:144811"
                     /db_xref="HGNC:HGNC:26789"
                     /db_xref="MIM:613409"
ORIGIN      
        1 maeavlidlf glklnsqknc hqtllktlna vqyhhaakak flcimccsni syerdgeqdn
       61 ceietsngls alleefeivs cpsmaatlyt ikqkideknl ssikvivprh rktlmkafid
      121 qlftdvynfe fedlqvtfrg glfkqsiein vitaqelrgi qneietflrs lpalrgklti
      181 itsslipdif ihgfttrtgg isyiptlssf nlfssskrrd pkvvvqenlr rlanaagfnv
      241 ekfyrikthh sndiwimgrk epdsydgitt nqrgvtiaal gadcipivfa dpvkkacgva
      301 hagsktfsln iskikqsk
//
LOCUS       XP_047286065             318 aa            linear   PRI 05-AUG-2025
DEFINITION  purine nucleoside phosphorylase LACC1 isoform X3 [Homo sapiens].
ACCESSION   XP_047286065
VERSION     XP_047286065.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430109.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..318
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..318
                     /product="purine nucleoside phosphorylase LACC1 isoform
                     X3"
                     /calculated_mol_wt=35486
     Region          195..>303
                     /region_name="Cu-oxidase_4"
                     /note="Multi-copper polyphenol oxidoreductase laccase;
                     pfam02578"
                     /db_xref="CDD:460601"
     CDS             1..318
                     /gene="LACC1"
                     /gene_synonym="C13orf31; FAMIN; JUVAR"
                     /coded_by="XM_047430109.1:113..1069"
                     /db_xref="GeneID:144811"
                     /db_xref="HGNC:HGNC:26789"
                     /db_xref="MIM:613409"
ORIGIN      
        1 maeavlidlf glklnsqknc hqtllktlna vqyhhaakak flcimccsni syerdgeqdn
       61 ceietsngls alleefeivs cpsmaatlyt ikqkideknl ssikvivprh rktlmkafid
      121 qlftdvynfe fedlqvtfrg glfkqsiein vitaqelrgi qneietflrs lpalrgklti
      181 itsslipdif ihgfttrtgg isyiptlssf nlfssskrrd pkvvvqenlr rlanaagfnv
      241 ekfyrikthh sndiwimgrk epdsydgitt nqrgvtiaal gadcipivfa dpvkkacgva
      301 hagsktfsln iskikqsk
//
LOCUS       XP_011533238             458 aa            linear   PRI 05-AUG-2025
DEFINITION  beta-1,3-glucosyltransferase isoform X1 [Homo sapiens].
ACCESSION   XP_011533238
VERSION     XP_011533238.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534936.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..458
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..458
                     /product="beta-1,3-glucosyltransferase isoform X1"
                     /calculated_mol_wt=52318
     Region          264..427
                     /region_name="Galactosyl_T"
                     /note="Galactosyltransferase; cl21608"
                     /db_xref="CDD:473923"
     CDS             1..458
                     /gene="B3GLCT"
                     /gene_synonym="B3GALTL; B3Glc-T; B3GTL; beta3Glc-T; Gal-T"
                     /coded_by="XM_011534936.2:111..1487"
                     /db_xref="GeneID:145173"
                     /db_xref="HGNC:HGNC:20207"
                     /db_xref="MIM:610308"
ORIGIN      
        1 mrppacwwll appallallt cslafglase dtkkevkqsq dleksgisrk ndidlkgivf
       61 viqsqsnsfh akraeqlkks ilkqaadltq elpsvlllhq lakqegawti lpllphfsvt
      121 ysrnsswiff ceeetriqip klletlrryd pskewflgka lhdeeatiih hyafsenptv
      181 fkypdfaagw alsiplvnkl tkrlkseslk sdftidlkhe ialyiwdkgg gppltpvpef
      241 ctndvdfyca ttfhsflplc rkpvkkkdif vavktckkfh gdripivkqt wesqasliey
      301 ysdytensip tvdlgipntd rghcgktfai lerflnrsqd ktawlvivdd dtlirmvfsr
      361 eavrrllask crcysndapd dmvlgmcfsg lgipvthspl fhqarpvdyp kdylshqvpi
      421 sfhkhwnidp vkvyftwlap sdedkarqet qkgfreel
//
LOCUS       XP_006719831             479 aa            linear   PRI 05-AUG-2025
DEFINITION  beta-1,3-glucosyltransferase isoform X2 [Homo sapiens].
ACCESSION   XP_006719831
VERSION     XP_006719831.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006719768.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..479
                     /product="beta-1,3-glucosyltransferase isoform X2"
                     /calculated_mol_wt=54411
     Region          245..448
                     /region_name="Fringe"
                     /note="Fringe-like; pfam02434"
                     /db_xref="CDD:367085"
     CDS             1..479
                     /gene="B3GLCT"
                     /gene_synonym="B3GALTL; B3Glc-T; B3GTL; beta3Glc-T; Gal-T"
                     /coded_by="XM_006719768.4:41..1480"
                     /db_xref="GeneID:145173"
                     /db_xref="HGNC:HGNC:20207"
                     /db_xref="MIM:610308"
ORIGIN      
        1 mrlpafglas edtkkevkqs qdleksgisr kndidlkgiv fviqsqsnsf hakraeqlkk
       61 silkqaadlt qelpsvlllh qlakqegawt ilpllphfsv tysrnsswif fceeetriqi
      121 pklletlrry dpskewflgk alhdeeatii hhyafsenpt vfkypdfaag walsiplvnk
      181 ltkrlksesl ksdftidlkh eialyiwdkg ggppltpvpe fctndvdfyc attfhsflpl
      241 crkpvkkkdi fvavktckkf hgdripivkq twesqaslie yysdytensi ptvdlgipnt
      301 drghcgktfa ilerflnrsq dktawlvivd ddtlisisrl qhllscydsg epvflgeryg
      361 yglgtggysy itggggmvfs reavrrllas kcrcysndap ddmvlgmcfs glgipvthsp
      421 lfhqarpvdy pkdylshqvp isfhkhwnid pvkvyftwla psdedkarqe tqkgfreel
//
LOCUS       XP_047286066             449 aa            linear   PRI 05-AUG-2025
DEFINITION  beta-1,3-glucosyltransferase isoform X3 [Homo sapiens].
ACCESSION   XP_047286066
VERSION     XP_047286066.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430110.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..449
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..449
                     /product="beta-1,3-glucosyltransferase isoform X3"
                     /calculated_mol_wt=50984
     Region          215..418
                     /region_name="Galactosyl_T"
                     /note="Galactosyltransferase; cl21608"
                     /db_xref="CDD:473923"
     CDS             1..449
                     /gene="B3GLCT"
                     /gene_synonym="B3GALTL; B3Glc-T; B3GTL; beta3Glc-T; Gal-T"
                     /coded_by="XM_047430110.1:104..1453"
                     /db_xref="GeneID:145173"
                     /db_xref="HGNC:HGNC:20207"
                     /db_xref="MIM:610308"
ORIGIN      
        1 mvsgdlkgiv fviqsqsnsf hakraeqlkk silkqaadlt qelpsvlllh qlakqegawt
       61 ilpllphfsv tysrnsswif fceeetriqi pklletlrry dpskewflgk alhdeeatii
      121 hhyafsenpt vfkypdfaag walsiplvnk ltkrlksesl ksdftidlkh eialyiwdkg
      181 ggppltpvpe fctndvdfyc attfhsflpl crkpvkkkdi fvavktckkf hgdripivkq
      241 twesqaslie yysdytensi ptvdlgipnt drghcgktfa ilerflnrsq dktawlvivd
      301 ddtlisisrl qhllscydsg epvflgeryg yglgtggysy itggggmvfs reavrrllas
      361 kcrcysndap ddmvlgmcfs glgipvthsp lfhqarpvdy pkdylshqvp isfhkhwnid
      421 pvkvyftwla psdedkarqe tqkgfreel
//
LOCUS       XP_011533240             449 aa            linear   PRI 05-AUG-2025
DEFINITION  beta-1,3-glucosyltransferase isoform X3 [Homo sapiens].
ACCESSION   XP_011533240
VERSION     XP_011533240.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534938.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..449
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..449
                     /product="beta-1,3-glucosyltransferase isoform X3"
                     /calculated_mol_wt=50984
     Region          215..418
                     /region_name="Galactosyl_T"
                     /note="Galactosyltransferase; cl21608"
                     /db_xref="CDD:473923"
     CDS             1..449
                     /gene="B3GLCT"
                     /gene_synonym="B3GALTL; B3Glc-T; B3GTL; beta3Glc-T; Gal-T"
                     /coded_by="XM_011534938.3:97..1446"
                     /db_xref="GeneID:145173"
                     /db_xref="HGNC:HGNC:20207"
                     /db_xref="MIM:610308"
ORIGIN      
        1 mvsgdlkgiv fviqsqsnsf hakraeqlkk silkqaadlt qelpsvlllh qlakqegawt
       61 ilpllphfsv tysrnsswif fceeetriqi pklletlrry dpskewflgk alhdeeatii
      121 hhyafsenpt vfkypdfaag walsiplvnk ltkrlksesl ksdftidlkh eialyiwdkg
      181 ggppltpvpe fctndvdfyc attfhsflpl crkpvkkkdi fvavktckkf hgdripivkq
      241 twesqaslie yysdytensi ptvdlgipnt drghcgktfa ilerflnrsq dktawlvivd
      301 ddtlisisrl qhllscydsg epvflgeryg yglgtggysy itggggmvfs reavrrllas
      361 kcrcysndap ddmvlgmcfs glgipvthsp lfhqarpvdy pkdylshqvp isfhkhwnid
      421 pvkvyftwla psdedkarqe tqkgfreel
//
LOCUS       XP_047286067             298 aa            linear   PRI 05-AUG-2025
DEFINITION  beta-1,3-glucosyltransferase isoform X4 [Homo sapiens].
ACCESSION   XP_047286067
VERSION     XP_047286067.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430111.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..298
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..298
                     /product="beta-1,3-glucosyltransferase isoform X4"
                     /calculated_mol_wt=33927
     Region          264..>283
                     /region_name="Galactosyl_T"
                     /note="Galactosyltransferase; cl21608"
                     /db_xref="CDD:473923"
     CDS             1..298
                     /gene="B3GLCT"
                     /gene_synonym="B3GALTL; B3Glc-T; B3GTL; beta3Glc-T; Gal-T"
                     /coded_by="XM_047430111.1:111..1007"
                     /db_xref="GeneID:145173"
                     /db_xref="HGNC:HGNC:20207"
                     /db_xref="MIM:610308"
ORIGIN      
        1 mrppacwwll appallallt cslafglase dtkkevkqsq dleksgisrk ndidlkgivf
       61 viqsqsnsfh akraeqlkks ilkqaadltq elpsvlllhq lakqegawti lpllphfsvt
      121 ysrnsswiff ceeetriqip klletlrryd pskewflgka lhdeeatiih hyafsenptv
      181 fkypdfaagw alsiplvnkl tkrlkseslk sdftidlkhe ialyiwdkgg gppltpvpef
      241 ctndvdfyca ttfhsflplc rkpvkkkdif vavktckkfh gdrtsssimq wrifyptv
//
LOCUS       XP_011533242             614 aa            linear   PRI 05-AUG-2025
DEFINITION  dachshund homolog 1 isoform X1 [Homo sapiens].
ACCESSION   XP_011533242
VERSION     XP_011533242.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534940.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..614
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..614
                     /product="dachshund homolog 1 isoform X1"
                     /calculated_mol_wt=62073
     Region          186..280
                     /region_name="DHD_Dac"
                     /note="Dachshund-homology domain found in the retinal
                     determination protein Dachshund and similar proteins;
                     cd21081"
                     /db_xref="CDD:410784"
     CDS             1..614
                     /gene="DACH1"
                     /gene_synonym="DACH"
                     /coded_by="XM_011534940.3:436..2280"
                     /db_xref="GeneID:1602"
                     /db_xref="HGNC:HGNC:2663"
                     /db_xref="MIM:603803"
ORIGIN      
        1 mavpaalipp tqlvppqppi stsasssgtt tstssatssp apsigppass gptlfrpepi
       61 asaaaaaatv tstggggggg gsgggggssg nggggggggg gsncnpnlaa asngsggggg
      121 gisagggvas stpinastgs ssssssssss ssssssssss ssscgplpgk pvystpspve
      181 ntpqnneckm vdlrgakvas ftvegcelic lpqafdlflk hlvgglhtvy tklkrleitp
      241 vvcnveqvri lrglgaiqpg vnrcklisrk dfetlyndct nassrpgrpp krtqsvtspe
      301 nshimphsvp glmspgiipp tgltaaaaaa aaatnaaiae amkvkkikle amsnyhasnn
      361 qhgadsengd mnssvgssdg swdketlpss psqgpqasit hprmpgarsl plshplnhlq
      421 qshllpngle lpfmmmphpl ipvslppasv tmamsqmnhl stianmaaaa qvqsppsrve
      481 tsvikervpd spspapslee grrpgshpss hrsssvsssp artesssdri pvhqnglsmn
      541 qmlmglspnv lpgpkegdla ghdmgheskr mhiekvhiil triqldftkn tglnmhkrlq
      601 cgmcadssvs srhy
//
LOCUS       XP_016875885             417 aa            linear   PRI 05-AUG-2025
DEFINITION  dachshund homolog 1 isoform X3 [Homo sapiens].
ACCESSION   XP_016875885
VERSION     XP_016875885.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020396.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..417
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..417
                     /product="dachshund homolog 1 isoform X3"
                     /calculated_mol_wt=45721
     Region          <274..389
                     /region_name="ATP-synt_Fo_b"
                     /note="F-type ATP synthase, membrane subunit b; cl21478"
                     /db_xref="CDD:473877"
     CDS             1..417
                     /gene="DACH1"
                     /gene_synonym="DACH"
                     /coded_by="XM_017020396.2:169..1422"
                     /db_xref="GeneID:1602"
                     /db_xref="HGNC:HGNC:2663"
                     /db_xref="MIM:603803"
ORIGIN      
        1 mkvkkiklea msnyhasnnq hgadsengdm nssvgssdgs wdketlpssp sqgpqasith
       61 prmpgarslp lshplnhlqq shllpnglel pfmmmphpli pvslppasvt mamsqmnhls
      121 tianmaaaaq vqsppsrvet svikervpds pspapsleeg rrpgshpssh rsssvssspa
      181 rtesssdrip vhqnglsmnq mlmglspnvl pgpkegdlag hdmgheskrm hiekdetpls
      241 tptardsldk lsltghgqpl ppgfpspflf pdglssietl ltniqgllkv aidnaraqek
      301 qvqlektelk mdflrerelr etlekqlame qknraivqkr lkkekkakrk lqealefetk
      361 rreqaeqtlk qaastdslrv lndsltpeie adrsggrtda ertiqdgrly lkttvmy
//
LOCUS       XP_011533243             379 aa            linear   PRI 05-AUG-2025
DEFINITION  dachshund homolog 1 isoform X2 [Homo sapiens].
ACCESSION   XP_011533243
VERSION     XP_011533243.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534941.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..379
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..379
                     /product="dachshund homolog 1 isoform X2"
                     /calculated_mol_wt=36785
     Region          186..280
                     /region_name="DHD_Dac"
                     /note="Dachshund-homology domain found in the retinal
                     determination protein Dachshund and similar proteins;
                     cd21081"
                     /db_xref="CDD:410784"
     CDS             1..379
                     /gene="DACH1"
                     /gene_synonym="DACH"
                     /coded_by="XM_011534941.3:436..1575"
                     /db_xref="GeneID:1602"
                     /db_xref="HGNC:HGNC:2663"
                     /db_xref="MIM:603803"
ORIGIN      
        1 mavpaalipp tqlvppqppi stsasssgtt tstssatssp apsigppass gptlfrpepi
       61 asaaaaaatv tstggggggg gsgggggssg nggggggggg gsncnpnlaa asngsggggg
      121 gisagggvas stpinastgs ssssssssss ssssssssss ssscgplpgk pvystpspve
      181 ntpqnneckm vdlrgakvas ftvegcelic lpqafdlflk hlvgglhtvy tklkrleitp
      241 vvcnveqvri lrglgaiqpg vnrcklisrk dfetlyndct nassrpgrpp krtqsvtspe
      301 nshimphsvp glmspgiipp tgltaaaaaa aaatnaaiae amkvkkikle amsnyhasnn
      361 qhgadsengd mnssvgwli
//
LOCUS       XP_016875886             273 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 122 isoform X1 [Homo
            sapiens].
ACCESSION   XP_016875886
VERSION     XP_016875886.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020397.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..273
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..273
                     /product="coiled-coil domain-containing protein 122
                     isoform X1"
                     /calculated_mol_wt=32075
     Region          31..>267
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..273
                     /gene="CCDC122"
                     /coded_by="XM_017020397.3:306..1127"
                     /db_xref="GeneID:160857"
                     /db_xref="HGNC:HGNC:26478"
                     /db_xref="MIM:613408"
ORIGIN      
        1 msdnkerksq gfpkednqdt ssladavekv akqqqsqase ieknkkvlfn lknelhelek
       61 eiaaisaetk eterqiyqqd saientklhc dsletqiksl hsenvklkfd ietaqedfee
      121 hmikynayya kikahknslg eveskwsfmt elhekrdfvk klktmkeelm qdlqnpggnr
      181 itqvqeditn lkdkiitvke siiektcfle eekktheklr keievqhkry dailkrlhcq
      241 vnklqsnrrq wqwniqqlek taaelrkcig mqe
//
LOCUS       XP_016875887             251 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 122 isoform X2 [Homo
            sapiens].
ACCESSION   XP_016875887
VERSION     XP_016875887.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020398.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..251
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..251
                     /product="coiled-coil domain-containing protein 122
                     isoform X2"
                     /calculated_mol_wt=28966
     Region          31..>225
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..251
                     /gene="CCDC122"
                     /coded_by="XM_017020398.2:306..1061"
                     /db_xref="GeneID:160857"
                     /db_xref="HGNC:HGNC:26478"
                     /db_xref="MIM:613408"
ORIGIN      
        1 msdnkerksq gfpkednqdt ssladavekv akqqqsqase ieknkkvlfn lknelhelek
       61 eiaaisaetk eterqiyqqd saientklhc dsletqiksl hsenvklkfd ietaqedfee
      121 hmikynayya kikahknslg eveskwsfmt elhekrdfvk klktmkeelm qdlqnpggnr
      181 itqvqeditn lkdkiitvke siiektcfle eekktheklr keietlhhps tgviladhki
      241 sleteissip l
//
LOCUS       XP_047286068             245 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 122 isoform X3 [Homo
            sapiens].
ACCESSION   XP_047286068
VERSION     XP_047286068.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430112.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..245
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..245
                     /product="coiled-coil domain-containing protein 122
                     isoform X3"
                     /calculated_mol_wt=28416
     Region          31..>228
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..245
                     /gene="CCDC122"
                     /coded_by="XM_047430112.1:310..1047"
                     /db_xref="GeneID:160857"
                     /db_xref="HGNC:HGNC:26478"
                     /db_xref="MIM:613408"
ORIGIN      
        1 msdnkerksq gfpkednqdt ssladavekv akqqqsqase ieknkkvlfn lknelhelek
       61 eiaaisaetk eterqiyqqd saientklhc dsletqiksl hsenvklkfd ietaqedfee
      121 hmikynayya kikahknslg eveskwsfmt elhekrdfvk klktmkeelm qdlqnpggnr
      181 itqvqeditn lkdkiitvke siiektcfle eekktheklr keieakrddp ieactthsps
      241 rsikf
//
LOCUS       XP_047286069             245 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 122 isoform X3 [Homo
            sapiens].
ACCESSION   XP_047286069
VERSION     XP_047286069.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430113.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..245
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..245
                     /product="coiled-coil domain-containing protein 122
                     isoform X3"
                     /calculated_mol_wt=28416
     Region          31..>228
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..245
                     /gene="CCDC122"
                     /coded_by="XM_047430113.1:310..1047"
                     /db_xref="GeneID:160857"
                     /db_xref="HGNC:HGNC:26478"
                     /db_xref="MIM:613408"
ORIGIN      
        1 msdnkerksq gfpkednqdt ssladavekv akqqqsqase ieknkkvlfn lknelhelek
       61 eiaaisaetk eterqiyqqd saientklhc dsletqiksl hsenvklkfd ietaqedfee
      121 hmikynayya kikahknslg eveskwsfmt elhekrdfvk klktmkeelm qdlqnpggnr
      181 itqvqeditn lkdkiitvke siiektcfle eekktheklr keieakrddp ieactthsps
      241 rsikf
//
LOCUS       XP_047286070             239 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 122 isoform X4 [Homo
            sapiens].
ACCESSION   XP_047286070
VERSION     XP_047286070.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430114.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..239
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..239
                     /product="coiled-coil domain-containing protein 122
                     isoform X4"
                     /calculated_mol_wt=27939
     Region          31..>224
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..239
                     /gene="CCDC122"
                     /coded_by="XM_047430114.1:306..1025"
                     /db_xref="GeneID:160857"
                     /db_xref="HGNC:HGNC:26478"
                     /db_xref="MIM:613408"
ORIGIN      
        1 msdnkerksq gfpkednqdt ssladavekv akqqqsqase ieknkkvlfn lknelhelek
       61 eiaaisaetk eterqiyqqd saientklhc dsletqiksl hsenvklkfd ietaqedfee
      121 hmikynayya kikahknslg eveskwsfmt elhekrdfvk klktmkeelm qdlqnpggnr
      181 itqvqeditn lkdkiitvke siiektcfle eekktheklr keievslnyl dfnvlwdhf
//
LOCUS       XP_024305092             152 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 122 isoform X5 [Homo
            sapiens].
ACCESSION   XP_024305092
VERSION     XP_024305092.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449324.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..152
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..152
                     /product="coiled-coil domain-containing protein 122
                     isoform X5"
                     /calculated_mol_wt=18158
     CDS             1..152
                     /gene="CCDC122"
                     /coded_by="XM_024449324.2:563..1021"
                     /db_xref="GeneID:160857"
                     /db_xref="HGNC:HGNC:26478"
                     /db_xref="MIM:613408"
ORIGIN      
        1 mikynayyak ikahknslge veskwsfmte lhekrdfvkk lktmkeelmq dlqnpggnri
       61 tqvqeditnl kdkiitvkes iiektcflee ekktheklrk eievqhkryd ailkrlhcqv
      121 nklqsnrrqw qwniqqlekt aaelrkcigm qe
//
LOCUS       XP_024305095             152 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 122 isoform X5 [Homo
            sapiens].
ACCESSION   XP_024305095
VERSION     XP_024305095.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449327.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..152
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..152
                     /product="coiled-coil domain-containing protein 122
                     isoform X5"
                     /calculated_mol_wt=18158
     CDS             1..152
                     /gene="CCDC122"
                     /coded_by="XM_024449327.2:514..972"
                     /db_xref="GeneID:160857"
                     /db_xref="HGNC:HGNC:26478"
                     /db_xref="MIM:613408"
ORIGIN      
        1 mikynayyak ikahknslge veskwsfmte lhekrdfvkk lktmkeelmq dlqnpggnri
       61 tqvqeditnl kdkiitvkes iiektcflee ekktheklrk eievqhkryd ailkrlhcqv
      121 nklqsnrrqw qwniqqlekt aaelrkcigm qe
//
LOCUS       XP_016875889             220 aa            linear   PRI 05-AUG-2025
DEFINITION  stomatin-like protein 3 isoform X1 [Homo sapiens].
ACCESSION   XP_016875889
VERSION     XP_016875889.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020400.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..220
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..220
                     /product="stomatin-like protein 3 isoform X1"
                     /calculated_mol_wt=23909
     Region          6..200
                     /region_name="SPFH_like"
                     /note="core domain of the SPFH (stomatin, prohibitin,
                     flotillin, and HflK/C) superfamily; cl19107"
                     /db_xref="CDD:473137"
     CDS             1..220
                     /gene="STOML3"
                     /gene_synonym="Epb7.2l; SRO"
                     /coded_by="XM_017020400.1:60..722"
                     /db_xref="GeneID:161003"
                     /db_xref="HGNC:HGNC:19420"
                     /db_xref="MIM:608327"
ORIGIN      
        1 mdvleglilv lpcidvfvkv dlrtvtcnip pqeiltrdsv ttqvdgvvyy riysavsava
       61 nvndvhqatf llaqttlrnv lgtqtlsqil agreeiahsi qtllddatel wgirvarvei
      121 kdvripvqlq rsmaaeaeat rearakvlaa egemnasksl ksasmvlaes pialqlrylq
      181 tlstvatekn stivfplpmn ilegiggvsy dnhkklpnka
//
LOCUS       XP_011519351             456 aa            linear   PRI 05-AUG-2025
DEFINITION  L-dopachrome tautomerase isoform X1 [Homo sapiens].
ACCESSION   XP_011519351
VERSION     XP_011519351.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521049.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..456
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..456
                     /product="L-dopachrome tautomerase isoform X1"
                     /calculated_mol_wt=52185
     Region          117..346
                     /region_name="Tyrosinase"
                     /note="Common central domain of tyrosinase; pfam00264"
                     /db_xref="CDD:425566"
     CDS             1..456
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /coded_by="XM_011521049.3:382..1752"
                     /db_xref="GeneID:1638"
                     /db_xref="HGNC:HGNC:2709"
                     /db_xref="MIM:191275"
ORIGIN      
        1 mllgiqrqmk crlrsdvtkr leedehvnth spmrrgnfag yncgdckfgw tgpncerkkp
       61 pvirqnihsl spqereqflg aldlakkrvh pdyvittqhw lgllgpngtq pqfancsvyd
      121 ffvwlhyysv rdtllgpgrp yraidfshqg pafvtwhryh llclerdlqr lignesfalp
      181 ywnfatgrne cdvctdqlfg aarpddptli srnsrfsswe tvcdslddyn hlvtlcngty
      241 egllrrnqmg rnsmklptlk dirdclslqk fdnppffqns tfsfrnaleg fdkadgtlds
      301 qvmslhnlvh sflngtnalp hsaandpifv vlhsftdaif dewmkrfnpp adawpqelap
      361 ighnrmynmv pffppvtnee lfltsdqlgy syaidlpvsv eetpgwpttl lvvmgtlval
      421 vglfvllafl qyrrlrkgyt plmethlssk ryteea
//
LOCUS       XP_047286071             423 aa            linear   PRI 05-AUG-2025
DEFINITION  L-dopachrome tautomerase isoform X2 [Homo sapiens].
ACCESSION   XP_047286071
VERSION     XP_047286071.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430115.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..423
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..423
                     /product="L-dopachrome tautomerase isoform X2"
                     /calculated_mol_wt=47819
     Region          180..392
                     /region_name="Tyrosinase"
                     /note="Common central domain of tyrosinase; pfam00264"
                     /db_xref="CDD:425566"
     CDS             1..423
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /coded_by="XM_047430115.1:428..1699"
                     /db_xref="GeneID:1638"
                     /db_xref="HGNC:HGNC:2709"
                     /db_xref="MIM:191275"
ORIGIN      
        1 msplwwgfll sclgckilpg aqgqfprvcm tvdslvnkec cprlgaesan vcgsqqgrgq
       61 ctevradtrp wsgpyilrnq ddrelwprkf fhrtckctgn fagyncgdck fgwtgpncer
      121 kkppvirqni hslspqereq flgaldlakk rvhpdyvitt qhwlgllgpn gtqpqfancs
      181 vydffvwlhy ysvrdtllgp grpyraidfs hqgpafvtwh ryhllclerd lqrlignesf
      241 alpywnfatg rnecdvctdq lfgaarpddp tlisrnsrfs swetvcdsld dynhlvtlcn
      301 gtyegllrrn qmgrnsmklp tlkdirdcls lqkfdnppff qnstfsfrna legfdkadgt
      361 ldsqvmslhn lvhsflngtn alphsaandp ifvkresdqg tpfpacagnh epgrlysgss
      421 fly
//
LOCUS       XP_016875890             562 aa            linear   PRI 05-AUG-2025
DEFINITION  L-dopachrome tautomerase isoform X3 [Homo sapiens].
ACCESSION   XP_016875890
VERSION     XP_016875890.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020401.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..562
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..562
                     /product="L-dopachrome tautomerase isoform X3"
                     /calculated_mol_wt=63760
     Region          180..392
                     /region_name="Tyrosinase"
                     /note="Common central domain of tyrosinase; pfam00264"
                     /db_xref="CDD:425566"
     CDS             1..562
                     /gene="DCT"
                     /gene_synonym="OCA8; TRP-2; TYRP2"
                     /coded_by="XM_017020401.3:428..2116"
                     /db_xref="GeneID:1638"
                     /db_xref="HGNC:HGNC:2709"
                     /db_xref="MIM:191275"
ORIGIN      
        1 msplwwgfll sclgckilpg aqgqfprvcm tvdslvnkec cprlgaesan vcgsqqgrgq
       61 ctevradtrp wsgpyilrnq ddrelwprkf fhrtckctgn fagyncgdck fgwtgpncer
      121 kkppvirqni hslspqereq flgaldlakk rvhpdyvitt qhwlgllgpn gtqpqfancs
      181 vydffvwlhy ysvrdtllgp grpyraidfs hqgpafvtwh ryhllclerd lqrlignesf
      241 alpywnfatg rnecdvctdq lfgaarpddp tlisrnsrfs swetvcdsld dynhlvtlcn
      301 gtyegllrrn qmgrnsmklp tlkdirdcls lqkfdnppff qnstfsfrna legfdkadgt
      361 ldsqvmslhn lvhsflngtn alphsaandp ifvvisnrll ynattnileh vrkekatkel
      421 pslhvlvtms lggstqvlhs ftdaifdewm krfnppadaw pqelapighn rmynmvpffp
      481 pvtneelflt sdqlgysyai dlpvsveetp gwpttllvvm gtlvalvglf vllaflqyrr
      541 lrkgytplme thlsskryte ea
//
LOCUS       XP_016875895             335 aa            linear   PRI 05-AUG-2025
DEFINITION  ephrin-B2 isoform X1 [Homo sapiens].
ACCESSION   XP_016875895
VERSION     XP_016875895.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020406.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..335
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..335
                     /product="ephrin-B2 isoform X1"
                     /calculated_mol_wt=37421
     Region          43..167
                     /region_name="Ephrin-B_Ectodomain"
                     /note="Ectodomain of Ephrin B; cd10426"
                     /db_xref="CDD:259897"
     Site            order(59,98..100,105,108..109,111..113,115,117,119..125,
                     127)
                     /site_type="other"
                     /note="receptor binding site [polypeptide binding]"
                     /db_xref="CDD:259897"
     CDS             1..335
                     /gene="EFNB2"
                     /gene_synonym="ephrin-B2; EPLG5; Htk-L; HTKL; LERK5"
                     /coded_by="XM_017020406.3:13108..14115"
                     /db_xref="GeneID:1948"
                     /db_xref="HGNC:HGNC:3227"
                     /db_xref="MIM:600527"
ORIGIN      
        1 myfqrlqqhq vapqrfgfss rliytlwptv rklvrrhqmf vlrflpgqgl vlypqigdkl
       61 diicpkvdsk tvgqyeyykv ymvdkdqadr ctikkentpl lncakpdqdi kftikfqefs
      121 pnlwglefqk nkdyyiists ngslegldnq eggvcqtram kilmkvgqda ssagstrnkd
      181 ptrrpeleag tngrssttsp fvkpnpgsst dgnsaghsgn nilgsevalf agiasgciif
      241 iviiitlvvl llkyrrrhrk hspqhtttls lstlatpkrs gnnngsepsd iiiplrtads
      301 vfcphyekvs gdyghpvyiv qemppqspan iyykv
//
LOCUS       XP_047286073             264 aa            linear   PRI 05-AUG-2025
DEFINITION  protein-lysine methyltransferase METTL21C isoform X1 [Homo
            sapiens].
ACCESSION   XP_047286073
VERSION     XP_047286073.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430117.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..264
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..264
                     /product="protein-lysine methyltransferase METTL21C
                     isoform X1"
                     /calculated_mol_wt=29433
     Region          73..239
                     /region_name="AdoMet_MTases"
                     /note="S-adenosylmethionine-dependent methyltransferases
                     (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes
                     that use S-adenosyl-L-methionine (SAM or AdoMet) as a
                     substrate for methyltransfer, creating the product
                     S-adenosyl-L-homocysteine (AdoHcy); cl17173"
                     /db_xref="CDD:473071"
     Site            order(119..125,141..142,172,194)
                     /site_type="other"
                     /note="S-adenosylmethionine binding site [chemical
                     binding]"
                     /db_xref="CDD:100107"
     CDS             1..264
                     /gene="METTL21C"
                     /gene_synonym="C13orf39"
                     /coded_by="XM_047430117.1:631..1425"
                     /db_xref="GeneID:196541"
                     /db_xref="HGNC:HGNC:33717"
                     /db_xref="MIM:615259"
ORIGIN      
        1 mdvclssaqq pgrrgeglss pggwleaekk gapqkdstgg vleesnkiep slhslqkfvp
       61 tdyasytqeh yrfagkeivi qesiesygav vwpgamalcq yleehaeeln fqdakileig
      121 agpglvsiva silgaqvtat dlpdvlgnlq ynllkntlqc tahlpevkel vwgedldknf
      181 pksafyydyv lasdvvyhhy fldkllttmv ylsqpgtvll wankfrfstd yefldkfkqv
      241 fdttllaeyp essvklfkgi lkwd
//
LOCUS       XP_047286074             619 aa            linear   PRI 05-AUG-2025
DEFINITION  ETS-related transcription factor Elf-1 isoform X1 [Homo sapiens].
ACCESSION   XP_047286074
VERSION     XP_047286074.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430118.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..619
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..619
                     /product="ETS-related transcription factor Elf-1 isoform
                     X1"
                     /calculated_mol_wt=67367
     Region          2..111
                     /region_name="Elf-1_N"
                     /note="Transcription factor protein N terminal; pfam12310"
                     /db_xref="CDD:463529"
     Region          207..289
                     /region_name="ETS"
                     /note="erythroblast transformation specific domain;
                     smart00413"
                     /db_xref="CDD:197710"
     CDS             1..619
                     /gene="ELF1"
                     /gene_synonym="EFTUD1; RIA1"
                     /coded_by="XM_047430118.1:983..2842"
                     /db_xref="GeneID:1997"
                     /db_xref="HGNC:HGNC:3316"
                     /db_xref="MIM:189973"
ORIGIN      
        1 maavvqqndl vfefasnvme derqlgdpai fpavivehvp gadilnsyag lacveepndm
       61 itessldvae eeiidddddd itltveasch dgdetietie aaeallnmds pgpmldekri
      121 nnnifssped dmvvapvthv svtldgipev metqqvqeky adspgasspe qpkrkkgrkt
      181 kpprpdspat tpnisvkkkn kdgkgntiyl wefllallqd katcpkyikw tqrekgifkl
      241 vdskavsrlw gkhknkpdmn yetmgralry yyqrgilakv egqrlvyqfk empkdliyin
      301 dedpsssies sdpslsssat snrnqtsrsr vssspgvkgg attvlkpgns kaakpkdpve
      361 vaqpsevlrt vqptqspypt qlfrtvhvvq pvqavpegea artstmqdet lnssvqsirt
      421 iqaptqvpvv vsprnqqlht vtlqtvpltt viastdpsag tgsqkfilqa ipssqpmtvl
      481 kenvmlqsqk agsppsivlg paqvqqvlts nvqticngtv svasspsfsa tapvvtfspr
      541 ssqlvahppg tvitsviktq etktltqeve kkesedhlke ntekteqqpq pyvmvvsssn
      601 gftsqvamkq nellepnsf
//
LOCUS       XP_047286075             619 aa            linear   PRI 05-AUG-2025
DEFINITION  ETS-related transcription factor Elf-1 isoform X1 [Homo sapiens].
ACCESSION   XP_047286075
VERSION     XP_047286075.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430119.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..619
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..619
                     /product="ETS-related transcription factor Elf-1 isoform
                     X1"
                     /calculated_mol_wt=67367
     Region          2..111
                     /region_name="Elf-1_N"
                     /note="Transcription factor protein N terminal; pfam12310"
                     /db_xref="CDD:463529"
     Region          207..289
                     /region_name="ETS"
                     /note="erythroblast transformation specific domain;
                     smart00413"
                     /db_xref="CDD:197710"
     CDS             1..619
                     /gene="ELF1"
                     /gene_synonym="EFTUD1; RIA1"
                     /coded_by="XM_047430119.1:498..2357"
                     /db_xref="GeneID:1997"
                     /db_xref="HGNC:HGNC:3316"
                     /db_xref="MIM:189973"
ORIGIN      
        1 maavvqqndl vfefasnvme derqlgdpai fpavivehvp gadilnsyag lacveepndm
       61 itessldvae eeiidddddd itltveasch dgdetietie aaeallnmds pgpmldekri
      121 nnnifssped dmvvapvthv svtldgipev metqqvqeky adspgasspe qpkrkkgrkt
      181 kpprpdspat tpnisvkkkn kdgkgntiyl wefllallqd katcpkyikw tqrekgifkl
      241 vdskavsrlw gkhknkpdmn yetmgralry yyqrgilakv egqrlvyqfk empkdliyin
      301 dedpsssies sdpslsssat snrnqtsrsr vssspgvkgg attvlkpgns kaakpkdpve
      361 vaqpsevlrt vqptqspypt qlfrtvhvvq pvqavpegea artstmqdet lnssvqsirt
      421 iqaptqvpvv vsprnqqlht vtlqtvpltt viastdpsag tgsqkfilqa ipssqpmtvl
      481 kenvmlqsqk agsppsivlg paqvqqvlts nvqticngtv svasspsfsa tapvvtfspr
      541 ssqlvahppg tvitsviktq etktltqeve kkesedhlke ntekteqqpq pyvmvvsssn
      601 gftsqvamkq nellepnsf
//
LOCUS       XP_047286076             619 aa            linear   PRI 05-AUG-2025
DEFINITION  ETS-related transcription factor Elf-1 isoform X1 [Homo sapiens].
ACCESSION   XP_047286076
VERSION     XP_047286076.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430120.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..619
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..619
                     /product="ETS-related transcription factor Elf-1 isoform
                     X1"
                     /calculated_mol_wt=67367
     Region          2..111
                     /region_name="Elf-1_N"
                     /note="Transcription factor protein N terminal; pfam12310"
                     /db_xref="CDD:463529"
     Region          207..289
                     /region_name="ETS"
                     /note="erythroblast transformation specific domain;
                     smart00413"
                     /db_xref="CDD:197710"
     CDS             1..619
                     /gene="ELF1"
                     /gene_synonym="EFTUD1; RIA1"
                     /coded_by="XM_047430120.1:381..2240"
                     /db_xref="GeneID:1997"
                     /db_xref="HGNC:HGNC:3316"
                     /db_xref="MIM:189973"
ORIGIN      
        1 maavvqqndl vfefasnvme derqlgdpai fpavivehvp gadilnsyag lacveepndm
       61 itessldvae eeiidddddd itltveasch dgdetietie aaeallnmds pgpmldekri
      121 nnnifssped dmvvapvthv svtldgipev metqqvqeky adspgasspe qpkrkkgrkt
      181 kpprpdspat tpnisvkkkn kdgkgntiyl wefllallqd katcpkyikw tqrekgifkl
      241 vdskavsrlw gkhknkpdmn yetmgralry yyqrgilakv egqrlvyqfk empkdliyin
      301 dedpsssies sdpslsssat snrnqtsrsr vssspgvkgg attvlkpgns kaakpkdpve
      361 vaqpsevlrt vqptqspypt qlfrtvhvvq pvqavpegea artstmqdet lnssvqsirt
      421 iqaptqvpvv vsprnqqlht vtlqtvpltt viastdpsag tgsqkfilqa ipssqpmtvl
      481 kenvmlqsqk agsppsivlg paqvqqvlts nvqticngtv svasspsfsa tapvvtfspr
      541 ssqlvahppg tvitsviktq etktltqeve kkesedhlke ntekteqqpq pyvmvvsssn
      601 gftsqvamkq nellepnsf
//
LOCUS       XP_047286077             619 aa            linear   PRI 05-AUG-2025
DEFINITION  ETS-related transcription factor Elf-1 isoform X1 [Homo sapiens].
ACCESSION   XP_047286077
VERSION     XP_047286077.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430121.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..619
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..619
                     /product="ETS-related transcription factor Elf-1 isoform
                     X1"
                     /calculated_mol_wt=67367
     Region          2..111
                     /region_name="Elf-1_N"
                     /note="Transcription factor protein N terminal; pfam12310"
                     /db_xref="CDD:463529"
     Region          207..289
                     /region_name="ETS"
                     /note="erythroblast transformation specific domain;
                     smart00413"
                     /db_xref="CDD:197710"
     CDS             1..619
                     /gene="ELF1"
                     /gene_synonym="EFTUD1; RIA1"
                     /coded_by="XM_047430121.1:435..2294"
                     /db_xref="GeneID:1997"
                     /db_xref="HGNC:HGNC:3316"
                     /db_xref="MIM:189973"
ORIGIN      
        1 maavvqqndl vfefasnvme derqlgdpai fpavivehvp gadilnsyag lacveepndm
       61 itessldvae eeiidddddd itltveasch dgdetietie aaeallnmds pgpmldekri
      121 nnnifssped dmvvapvthv svtldgipev metqqvqeky adspgasspe qpkrkkgrkt
      181 kpprpdspat tpnisvkkkn kdgkgntiyl wefllallqd katcpkyikw tqrekgifkl
      241 vdskavsrlw gkhknkpdmn yetmgralry yyqrgilakv egqrlvyqfk empkdliyin
      301 dedpsssies sdpslsssat snrnqtsrsr vssspgvkgg attvlkpgns kaakpkdpve
      361 vaqpsevlrt vqptqspypt qlfrtvhvvq pvqavpegea artstmqdet lnssvqsirt
      421 iqaptqvpvv vsprnqqlht vtlqtvpltt viastdpsag tgsqkfilqa ipssqpmtvl
      481 kenvmlqsqk agsppsivlg paqvqqvlts nvqticngtv svasspsfsa tapvvtfspr
      541 ssqlvahppg tvitsviktq etktltqeve kkesedhlke ntekteqqpq pyvmvvsssn
      601 gftsqvamkq nellepnsf
//
LOCUS       XP_047286078             619 aa            linear   PRI 05-AUG-2025
DEFINITION  ETS-related transcription factor Elf-1 isoform X1 [Homo sapiens].
ACCESSION   XP_047286078
VERSION     XP_047286078.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430122.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..619
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..619
                     /product="ETS-related transcription factor Elf-1 isoform
                     X1"
                     /calculated_mol_wt=67367
     Region          2..111
                     /region_name="Elf-1_N"
                     /note="Transcription factor protein N terminal; pfam12310"
                     /db_xref="CDD:463529"
     Region          207..289
                     /region_name="ETS"
                     /note="erythroblast transformation specific domain;
                     smart00413"
                     /db_xref="CDD:197710"
     CDS             1..619
                     /gene="ELF1"
                     /gene_synonym="EFTUD1; RIA1"
                     /coded_by="XM_047430122.1:574..2433"
                     /db_xref="GeneID:1997"
                     /db_xref="HGNC:HGNC:3316"
                     /db_xref="MIM:189973"
ORIGIN      
        1 maavvqqndl vfefasnvme derqlgdpai fpavivehvp gadilnsyag lacveepndm
       61 itessldvae eeiidddddd itltveasch dgdetietie aaeallnmds pgpmldekri
      121 nnnifssped dmvvapvthv svtldgipev metqqvqeky adspgasspe qpkrkkgrkt
      181 kpprpdspat tpnisvkkkn kdgkgntiyl wefllallqd katcpkyikw tqrekgifkl
      241 vdskavsrlw gkhknkpdmn yetmgralry yyqrgilakv egqrlvyqfk empkdliyin
      301 dedpsssies sdpslsssat snrnqtsrsr vssspgvkgg attvlkpgns kaakpkdpve
      361 vaqpsevlrt vqptqspypt qlfrtvhvvq pvqavpegea artstmqdet lnssvqsirt
      421 iqaptqvpvv vsprnqqlht vtlqtvpltt viastdpsag tgsqkfilqa ipssqpmtvl
      481 kenvmlqsqk agsppsivlg paqvqqvlts nvqticngtv svasspsfsa tapvvtfspr
      541 ssqlvahppg tvitsviktq etktltqeve kkesedhlke ntekteqqpq pyvmvvsssn
      601 gftsqvamkq nellepnsf
//
LOCUS       XP_047286079             619 aa            linear   PRI 05-AUG-2025
DEFINITION  ETS-related transcription factor Elf-1 isoform X1 [Homo sapiens].
ACCESSION   XP_047286079
VERSION     XP_047286079.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430123.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..619
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..619
                     /product="ETS-related transcription factor Elf-1 isoform
                     X1"
                     /calculated_mol_wt=67367
     Region          2..111
                     /region_name="Elf-1_N"
                     /note="Transcription factor protein N terminal; pfam12310"
                     /db_xref="CDD:463529"
     Region          207..289
                     /region_name="ETS"
                     /note="erythroblast transformation specific domain;
                     smart00413"
                     /db_xref="CDD:197710"
     CDS             1..619
                     /gene="ELF1"
                     /gene_synonym="EFTUD1; RIA1"
                     /coded_by="XM_047430123.1:509..2368"
                     /db_xref="GeneID:1997"
                     /db_xref="HGNC:HGNC:3316"
                     /db_xref="MIM:189973"
ORIGIN      
        1 maavvqqndl vfefasnvme derqlgdpai fpavivehvp gadilnsyag lacveepndm
       61 itessldvae eeiidddddd itltveasch dgdetietie aaeallnmds pgpmldekri
      121 nnnifssped dmvvapvthv svtldgipev metqqvqeky adspgasspe qpkrkkgrkt
      181 kpprpdspat tpnisvkkkn kdgkgntiyl wefllallqd katcpkyikw tqrekgifkl
      241 vdskavsrlw gkhknkpdmn yetmgralry yyqrgilakv egqrlvyqfk empkdliyin
      301 dedpsssies sdpslsssat snrnqtsrsr vssspgvkgg attvlkpgns kaakpkdpve
      361 vaqpsevlrt vqptqspypt qlfrtvhvvq pvqavpegea artstmqdet lnssvqsirt
      421 iqaptqvpvv vsprnqqlht vtlqtvpltt viastdpsag tgsqkfilqa ipssqpmtvl
      481 kenvmlqsqk agsppsivlg paqvqqvlts nvqticngtv svasspsfsa tapvvtfspr
      541 ssqlvahppg tvitsviktq etktltqeve kkesedhlke ntekteqqpq pyvmvvsssn
      601 gftsqvamkq nellepnsf
//
LOCUS       XP_047286080             619 aa            linear   PRI 05-AUG-2025
DEFINITION  ETS-related transcription factor Elf-1 isoform X1 [Homo sapiens].
ACCESSION   XP_047286080
VERSION     XP_047286080.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430124.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..619
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..619
                     /product="ETS-related transcription factor Elf-1 isoform
                     X1"
                     /calculated_mol_wt=67367
     Region          2..111
                     /region_name="Elf-1_N"
                     /note="Transcription factor protein N terminal; pfam12310"
                     /db_xref="CDD:463529"
     Region          207..289
                     /region_name="ETS"
                     /note="erythroblast transformation specific domain;
                     smart00413"
                     /db_xref="CDD:197710"
     CDS             1..619
                     /gene="ELF1"
                     /gene_synonym="EFTUD1; RIA1"
                     /coded_by="XM_047430124.1:457..2316"
                     /db_xref="GeneID:1997"
                     /db_xref="HGNC:HGNC:3316"
                     /db_xref="MIM:189973"
ORIGIN      
        1 maavvqqndl vfefasnvme derqlgdpai fpavivehvp gadilnsyag lacveepndm
       61 itessldvae eeiidddddd itltveasch dgdetietie aaeallnmds pgpmldekri
      121 nnnifssped dmvvapvthv svtldgipev metqqvqeky adspgasspe qpkrkkgrkt
      181 kpprpdspat tpnisvkkkn kdgkgntiyl wefllallqd katcpkyikw tqrekgifkl
      241 vdskavsrlw gkhknkpdmn yetmgralry yyqrgilakv egqrlvyqfk empkdliyin
      301 dedpsssies sdpslsssat snrnqtsrsr vssspgvkgg attvlkpgns kaakpkdpve
      361 vaqpsevlrt vqptqspypt qlfrtvhvvq pvqavpegea artstmqdet lnssvqsirt
      421 iqaptqvpvv vsprnqqlht vtlqtvpltt viastdpsag tgsqkfilqa ipssqpmtvl
      481 kenvmlqsqk agsppsivlg paqvqqvlts nvqticngtv svasspsfsa tapvvtfspr
      541 ssqlvahppg tvitsviktq etktltqeve kkesedhlke ntekteqqpq pyvmvvsssn
      601 gftsqvamkq nellepnsf
//
LOCUS       XP_011533256             282 aa            linear   PRI 05-AUG-2025
DEFINITION  S-formylglutathione hydrolase isoform X1 [Homo sapiens].
ACCESSION   XP_011533256
VERSION     XP_011533256.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534954.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..282
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..282
                     /product="S-formylglutathione hydrolase isoform X1"
                     /calculated_mol_wt=31332
     Region          2..281
                     /region_name="PLN02442"
                     /note="S-formylglutathione hydrolase"
                     /db_xref="CDD:178061"
     CDS             1..282
                     /gene="ESD"
                     /gene_synonym="FGH"
                     /coded_by="XM_011534954.2:155..1003"
                     /db_xref="GeneID:2098"
                     /db_xref="HGNC:HGNC:3465"
                     /db_xref="MIM:133280"
ORIGIN      
        1 malkqissnk cfgglqkvfe hdsvelnckm kfavylppka etgkcpalyw lsgltcteqn
       61 fisksgyhqs asehglvvia pdtsprgcni kgedeswdfg tgagfyvdat edpwktnyrm
      121 ysyvteelpq linanfpvdp qrmsifghsm gghgalical knpgkyksvs afapicnpvl
      181 cpwgkkafsg ylgtdqskwk aydathlvks ypgsqldili dqgkddqfll dgqllpdnfi
      241 aactekkipv vfrlqegydh syyfiatfit dhirhhakyl na
//
LOCUS       XP_005266335             282 aa            linear   PRI 05-AUG-2025
DEFINITION  S-formylglutathione hydrolase isoform X1 [Homo sapiens].
ACCESSION   XP_005266335
VERSION     XP_005266335.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266278.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..282
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..282
                     /product="S-formylglutathione hydrolase isoform X1"
                     /calculated_mol_wt=31332
     Region          2..281
                     /region_name="PLN02442"
                     /note="S-formylglutathione hydrolase"
                     /db_xref="CDD:178061"
     CDS             1..282
                     /gene="ESD"
                     /gene_synonym="FGH"
                     /coded_by="XM_005266278.4:78..926"
                     /db_xref="GeneID:2098"
                     /db_xref="HGNC:HGNC:3465"
                     /db_xref="MIM:133280"
ORIGIN      
        1 malkqissnk cfgglqkvfe hdsvelnckm kfavylppka etgkcpalyw lsgltcteqn
       61 fisksgyhqs asehglvvia pdtsprgcni kgedeswdfg tgagfyvdat edpwktnyrm
      121 ysyvteelpq linanfpvdp qrmsifghsm gghgalical knpgkyksvs afapicnpvl
      181 cpwgkkafsg ylgtdqskwk aydathlvks ypgsqldili dqgkddqfll dgqllpdnfi
      241 aactekkipv vfrlqegydh syyfiatfit dhirhhakyl na
//
LOCUS       XP_011535776             495 aa            linear   PRI 05-AUG-2025
DEFINITION  coagulation factor VII isoform X1 [Homo sapiens].
ACCESSION   XP_011535776
VERSION     XP_011535776.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537474.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Jun 6, 2016 this sequence version replaced XP_011535776.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..495
                     /product="coagulation factor VII isoform X1"
                     /calculated_mol_wt=54827
     Region          36..97
                     /region_name="GLA"
                     /note="Domain containing Gla (gamma-carboxyglutamate)
                     residues; smart00069"
                     /db_xref="CDD:214503"
     Region          99..135
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(99,102,116)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          180..216
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          242..478
                     /region_name="Tryp_SPc"
                     /note="Trypsin-like serine protease; Many of these are
                     synthesized as inactive precursor zymogens that are
                     cleaved during limited proteolysis to generate their
                     active forms. Alignment contains also inactive enzymes
                     that have substitutions of the catalytic triad...;
                     cd00190"
                     /db_xref="CDD:238113"
     Site            242
                     /site_type="active"
                     /note="cleavage site [active]"
                     /db_xref="CDD:238113"
     Site            order(282,331,433)
                     /site_type="active"
                     /db_xref="CDD:238113"
     Site            order(427,452,454)
                     /site_type="other"
                     /note="substrate binding sites [chemical binding]"
                     /db_xref="CDD:238113"
     CDS             1..495
                     /gene="F7"
                     /gene_synonym="SPCA"
                     /coded_by="XM_011537474.3:7..1494"
                     /db_xref="GeneID:2155"
                     /db_xref="HGNC:HGNC:3544"
                     /db_xref="MIM:613878"
ORIGIN      
        1 mgnvnrqgqh crdfimvsqa lrllclllgl qgclaavfvt qeeahgvlhr rrranaflee
       61 lrpgslerec keeqcsfeea reifkdaert klfwisysdg dqcasspcqn ggsckdqlqs
      121 yicfclpafe grncetqesp aswrrlkrea scwssgsrmp gdlcsalvps spdkddqlic
      181 vnenggceqy csdhtgtkrs crchegysll adgvsctptv eypcgkipil ekrnaskpqg
      241 rivggkvcpk gecpwqvlll vngaqlcggt lintiwvvsa ahcfdkiknw rnliavlgeh
      301 dlsehdgdeq srrvaqviip styvpgttnh diallrlhqp vvltdhvvpl clpertfser
      361 tlafvrfslv sgwgqlldrg atalelmvln vprlmtqdcl qqsrkvgdsp niteymfcag
      421 ysdgskdsck gdsggphath yrgtwyltgi vswgqgcatv ghfgvytrvs qyiewlqklm
      481 rseprpgvll rapfp
//
LOCUS       XP_011535777             433 aa            linear   PRI 05-AUG-2025
DEFINITION  coagulation factor VII isoform X2 [Homo sapiens].
ACCESSION   XP_011535777
VERSION     XP_011535777.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537475.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Jun 6, 2016 this sequence version replaced XP_011535777.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..433
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..433
                     /product="coagulation factor VII isoform X2"
                     /calculated_mol_wt=47385
     Region          37..73
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(37,40,54)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          118..154
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          180..416
                     /region_name="Tryp_SPc"
                     /note="Trypsin-like serine protease; Many of these are
                     synthesized as inactive precursor zymogens that are
                     cleaved during limited proteolysis to generate their
                     active forms. Alignment contains also inactive enzymes
                     that have substitutions of the catalytic triad...;
                     cd00190"
                     /db_xref="CDD:238113"
     Site            180
                     /site_type="active"
                     /note="cleavage site [active]"
                     /db_xref="CDD:238113"
     Site            order(220,269,371)
                     /site_type="active"
                     /db_xref="CDD:238113"
     Site            order(365,390,392)
                     /site_type="other"
                     /note="substrate binding sites [chemical binding]"
                     /db_xref="CDD:238113"
     CDS             1..433
                     /gene="F7"
                     /gene_synonym="SPCA"
                     /coded_by="XM_011537475.3:7..1308"
                     /db_xref="GeneID:2155"
                     /db_xref="HGNC:HGNC:3544"
                     /db_xref="MIM:613878"
ORIGIN      
        1 mgnvnrqgqh crdfimvsqa lrllclllgl qgclaadgdq casspcqngg sckdqlqsyi
       61 cfclpafegr ncetqespas wrrlkreasc wssgsrmpgd lcsalvpssp dkddqlicvn
      121 enggceqycs dhtgtkrscr chegysllad gvsctptvey pcgkipilek rnaskpqgri
      181 vggkvcpkge cpwqvlllvn gaqlcggtli ntiwvvsaah cfdkiknwrn liavlgehdl
      241 sehdgdeqsr rvaqviipst yvpgttnhdi allrlhqpvv ltdhvvplcl pertfsertl
      301 afvrfslvsg wgqlldrgat alelmvlnvp rlmtqdclqq srkvgdspni teymfcagys
      361 dgskdsckgd sggphathyr gtwyltgivs wgqgcatvgh fgvytrvsqy iewlqklmrs
      421 eprpgvllra pfp
//
LOCUS       XP_047286081             452 aa            linear   PRI 05-AUG-2025
DEFINITION  coagulation factor VII isoform X3 [Homo sapiens].
ACCESSION   XP_047286081
VERSION     XP_047286081.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430125.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..452
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..452
                     /product="coagulation factor VII isoform X3"
                     /calculated_mol_wt=50018
     Region          34..90
                     /region_name="GLA"
                     /note="Domain containing Gla (gamma-carboxyglutamate)
                     residues; smart00069"
                     /db_xref="CDD:214503"
     Region          92..128
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(92,95,109)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          137..173
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          199..435
                     /region_name="Tryp_SPc"
                     /note="Trypsin-like serine protease; Many of these are
                     synthesized as inactive precursor zymogens that are
                     cleaved during limited proteolysis to generate their
                     active forms. Alignment contains also inactive enzymes
                     that have substitutions of the catalytic triad...;
                     cd00190"
                     /db_xref="CDD:238113"
     Site            199
                     /site_type="active"
                     /note="cleavage site [active]"
                     /db_xref="CDD:238113"
     Site            order(239,288,390)
                     /site_type="active"
                     /db_xref="CDD:238113"
     Site            order(384,409,411)
                     /site_type="other"
                     /note="substrate binding sites [chemical binding]"
                     /db_xref="CDD:238113"
     CDS             1..452
                     /gene="F7"
                     /gene_synonym="SPCA"
                     /coded_by="XM_047430125.1:14..1372"
                     /db_xref="GeneID:2155"
                     /db_xref="HGNC:HGNC:3544"
                     /db_xref="MIM:613878"
ORIGIN      
        1 mstgrgstae isswsprpsg ssafclgfra awlqeeahgv lhrrrranaf leelrpgsle
       61 reckeeqcsf eeareifkda ertklfwisy sdgdqcassp cqnggsckdq lqsyicfclp
      121 afegrnceth kddqlicvne nggceqycsd htgtkrscrc hegyslladg vsctptveyp
      181 cgkipilekr naskpqgriv ggkvcpkgec pwqvlllvng aqlcggtlin tiwvvsaahc
      241 fdkiknwrnl iavlgehdls ehdgdeqsrr vaqviipsty vpgttnhdia llrlhqpvvl
      301 tdhvvplclp ertfsertla fvrfslvsgw gqlldrgata lelmvlnvpr lmtqdclqqs
      361 rkvgdspnit eymfcagysd gskdsckgds ggphathyrg twyltgivsw gqgcatvghf
      421 gvytrvsqyi ewlqklmrse prpgvllrap fp
//
LOCUS       XP_006720026             412 aa            linear   PRI 05-AUG-2025
DEFINITION  coagulation factor VII isoform X4 [Homo sapiens].
ACCESSION   XP_006720026
VERSION     XP_006720026.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006719963.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Jun 6, 2016 this sequence version replaced XP_006720026.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..412
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..412
                     /product="coagulation factor VII isoform X4"
                     /calculated_mol_wt=45846
     Region          36..97
                     /region_name="GLA"
                     /note="Domain containing Gla (gamma-carboxyglutamate)
                     residues; smart00069"
                     /db_xref="CDD:214503"
     Region          99..135
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(99,102,116)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          159..395
                     /region_name="Tryp_SPc"
                     /note="Trypsin-like serine protease; Many of these are
                     synthesized as inactive precursor zymogens that are
                     cleaved during limited proteolysis to generate their
                     active forms. Alignment contains also inactive enzymes
                     that have substitutions of the catalytic triad...;
                     cd00190"
                     /db_xref="CDD:238113"
     Site            159
                     /site_type="active"
                     /note="cleavage site [active]"
                     /db_xref="CDD:238113"
     Site            order(199,248,350)
                     /site_type="active"
                     /db_xref="CDD:238113"
     Site            order(344,369,371)
                     /site_type="other"
                     /note="substrate binding sites [chemical binding]"
                     /db_xref="CDD:238113"
     CDS             1..412
                     /gene="F7"
                     /gene_synonym="SPCA"
                     /coded_by="XM_006719963.4:7..1245"
                     /db_xref="GeneID:2155"
                     /db_xref="HGNC:HGNC:3544"
                     /db_xref="MIM:613878"
ORIGIN      
        1 mgnvnrqgqh crdfimvsqa lrllclllgl qgclaavfvt qeeahgvlhr rrranaflee
       61 lrpgslerec keeqcsfeea reifkdaert klfwisysdg dqcasspcqn ggsckdqlqs
      121 yicfclpafe grncetleyp cgkipilekr naskpqgriv ggkvcpkgec pwqvlllvng
      181 aqlcggtlin tiwvvsaahc fdkiknwrnl iavlgehdls ehdgdeqsrr vaqviipsty
      241 vpgttnhdia llrlhqpvvl tdhvvplclp ertfsertla fvrfslvsgw gqlldrgata
      301 lelmvlnvpr lmtqdclqqs rkvgdspnit eymfcagysd gskdsckgds ggphathyrg
      361 twyltgivsw gqgcatvghf gvytrvsqyi ewlqklmrse prpgvllrap fp
//
LOCUS       XP_011535778             364 aa            linear   PRI 05-AUG-2025
DEFINITION  coagulation factor VII isoform X5 [Homo sapiens].
ACCESSION   XP_011535778
VERSION     XP_011535778.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537476.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..364
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..364
                     /product="coagulation factor VII isoform X5"
                     /calculated_mol_wt=39887
     Region          49..85
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          111..347
                     /region_name="Tryp_SPc"
                     /note="Trypsin-like serine protease; Many of these are
                     synthesized as inactive precursor zymogens that are
                     cleaved during limited proteolysis to generate their
                     active forms. Alignment contains also inactive enzymes
                     that have substitutions of the catalytic triad...;
                     cd00190"
                     /db_xref="CDD:238113"
     Site            111
                     /site_type="active"
                     /note="cleavage site [active]"
                     /db_xref="CDD:238113"
     Site            order(151,200,302)
                     /site_type="active"
                     /db_xref="CDD:238113"
     Site            order(296,321,323)
                     /site_type="other"
                     /note="substrate binding sites [chemical binding]"
                     /db_xref="CDD:238113"
     CDS             1..364
                     /gene="F7"
                     /gene_synonym="SPCA"
                     /coded_by="XM_011537476.3:768..1862"
                     /db_xref="GeneID:2155"
                     /db_xref="HGNC:HGNC:3544"
                     /db_xref="MIM:613878"
ORIGIN      
        1 maqgpeespa swrrlkreas cwssgsrmpg dlcsalvpss pdkddqlicv nenggceqyc
       61 sdhtgtkrsc rchegyslla dgvsctptve ypcgkipile krnaskpqgr ivggkvcpkg
      121 ecpwqvlllv ngaqlcggtl intiwvvsaa hcfdkiknwr nliavlgehd lsehdgdeqs
      181 rrvaqviips tyvpgttnhd iallrlhqpv vltdhvvplc lpertfsert lafvrfslvs
      241 gwgqlldrga talelmvlnv prlmtqdclq qsrkvgdspn iteymfcagy sdgskdsckg
      301 dsggphathy rgtwyltgiv swgqgcatvg hfgvytrvsq yiewlqklmr seprpgvllr
      361 apfp
//
LOCUS       XP_005266336             671 aa            linear   PRI 05-AUG-2025
DEFINITION  APC membrane recruitment protein 2 isoform X1 [Homo sapiens].
ACCESSION   XP_005266336
VERSION     XP_005266336.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266279.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..671
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..671
                     /product="APC membrane recruitment protein 2 isoform X1"
                     /calculated_mol_wt=69376
     Region          99..590
                     /region_name="WTX"
                     /note="WTX protein; pfam09422"
                     /db_xref="CDD:462794"
     CDS             1..671
                     /gene="AMER2"
                     /gene_synonym="FAM123A"
                     /coded_by="XM_005266279.5:356..2371"
                     /db_xref="GeneID:219287"
                     /db_xref="HGNC:HGNC:26360"
                     /db_xref="MIM:614659"
ORIGIN      
        1 metsrsrggg gavserggag asvgvcrrka eagagtgtla admdlhcdca aetpaaepps
       61 gkinkaafkl fkkrksggtm psifgvknkg dgkssgptgl vrsrthdgla evlvlesgrk
      121 eeprgggdsg gggggrpnpg ppraagpggg slasssvaks hsffsllkkn grsengkgep
      181 vdaskaggkq krglrglfsg mrwhrkdkra kaeaaegrap ggglilpgsl taslecvkee
      241 tpraarepee psqdaprdpa gepaggeevp apadrapars creaeglahp gdtgargeda
      301 aghrraepgp gevrtaedas rtgavpvktv plvdseggsg rapaapdpas vdppsdpsad
      361 riclmfsdvt slksfdsltg cgdiiadqee eagpscdkhv pgpgkpalsk knpgvvayqg
      421 ggeemaspde vddtylqefw dmlsqteeqg pepqegaakv aaaletkvvp etpkdtrcve
      481 aakdassvkr rrlnripiep hpkeepkhpe keqqegvpns degywdsttp gpeedssssg
      541 kkagiprdsy sgdalydlya dpdgspatlp ggkdneetss lsrlkpvspg titcplrtpg
      601 sllkdskipi sikhltnlps shpvvhqqps rsemprtkip vskvlvrrvs nrglagttir
      661 atachdsakk l
//
LOCUS       XP_005266337             671 aa            linear   PRI 05-AUG-2025
DEFINITION  APC membrane recruitment protein 2 isoform X1 [Homo sapiens].
ACCESSION   XP_005266337
VERSION     XP_005266337.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266280.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..671
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..671
                     /product="APC membrane recruitment protein 2 isoform X1"
                     /calculated_mol_wt=69376
     Region          99..590
                     /region_name="WTX"
                     /note="WTX protein; pfam09422"
                     /db_xref="CDD:462794"
     CDS             1..671
                     /gene="AMER2"
                     /gene_synonym="FAM123A"
                     /coded_by="XM_005266280.5:387..2402"
                     /db_xref="GeneID:219287"
                     /db_xref="HGNC:HGNC:26360"
                     /db_xref="MIM:614659"
ORIGIN      
        1 metsrsrggg gavserggag asvgvcrrka eagagtgtla admdlhcdca aetpaaepps
       61 gkinkaafkl fkkrksggtm psifgvknkg dgkssgptgl vrsrthdgla evlvlesgrk
      121 eeprgggdsg gggggrpnpg ppraagpggg slasssvaks hsffsllkkn grsengkgep
      181 vdaskaggkq krglrglfsg mrwhrkdkra kaeaaegrap ggglilpgsl taslecvkee
      241 tpraarepee psqdaprdpa gepaggeevp apadrapars creaeglahp gdtgargeda
      301 aghrraepgp gevrtaedas rtgavpvktv plvdseggsg rapaapdpas vdppsdpsad
      361 riclmfsdvt slksfdsltg cgdiiadqee eagpscdkhv pgpgkpalsk knpgvvayqg
      421 ggeemaspde vddtylqefw dmlsqteeqg pepqegaakv aaaletkvvp etpkdtrcve
      481 aakdassvkr rrlnripiep hpkeepkhpe keqqegvpns degywdsttp gpeedssssg
      541 kkagiprdsy sgdalydlya dpdgspatlp ggkdneetss lsrlkpvspg titcplrtpg
      601 sllkdskipi sikhltnlps shpvvhqqps rsemprtkip vskvlvrrvs nrglagttir
      661 atachdsakk l
//
LOCUS       XP_016875904             671 aa            linear   PRI 05-AUG-2025
DEFINITION  APC membrane recruitment protein 2 isoform X1 [Homo sapiens].
ACCESSION   XP_016875904
VERSION     XP_016875904.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020415.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..671
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..671
                     /product="APC membrane recruitment protein 2 isoform X1"
                     /calculated_mol_wt=69376
     Region          99..590
                     /region_name="WTX"
                     /note="WTX protein; pfam09422"
                     /db_xref="CDD:462794"
     CDS             1..671
                     /gene="AMER2"
                     /gene_synonym="FAM123A"
                     /coded_by="XM_017020415.2:259..2274"
                     /db_xref="GeneID:219287"
                     /db_xref="HGNC:HGNC:26360"
                     /db_xref="MIM:614659"
ORIGIN      
        1 metsrsrggg gavserggag asvgvcrrka eagagtgtla admdlhcdca aetpaaepps
       61 gkinkaafkl fkkrksggtm psifgvknkg dgkssgptgl vrsrthdgla evlvlesgrk
      121 eeprgggdsg gggggrpnpg ppraagpggg slasssvaks hsffsllkkn grsengkgep
      181 vdaskaggkq krglrglfsg mrwhrkdkra kaeaaegrap ggglilpgsl taslecvkee
      241 tpraarepee psqdaprdpa gepaggeevp apadrapars creaeglahp gdtgargeda
      301 aghrraepgp gevrtaedas rtgavpvktv plvdseggsg rapaapdpas vdppsdpsad
      361 riclmfsdvt slksfdsltg cgdiiadqee eagpscdkhv pgpgkpalsk knpgvvayqg
      421 ggeemaspde vddtylqefw dmlsqteeqg pepqegaakv aaaletkvvp etpkdtrcve
      481 aakdassvkr rrlnripiep hpkeepkhpe keqqegvpns degywdsttp gpeedssssg
      541 kkagiprdsy sgdalydlya dpdgspatlp ggkdneetss lsrlkpvspg titcplrtpg
      601 sllkdskipi sikhltnlps shpvvhqqps rsemprtkip vskvlvrrvs nrglagttir
      661 atachdsakk l
//
LOCUS       XP_005266339             312 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin carboxyl-terminal hydrolase 12 isoform X1 [Homo sapiens].
ACCESSION   XP_005266339
VERSION     XP_005266339.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266282.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..312
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..312
                     /product="ubiquitin carboxyl-terminal hydrolase 12 isoform
                     X1"
                     /calculated_mol_wt=36114
     Region          40..310
                     /region_name="Peptidase_C19G"
                     /note="A subfamily of Peptidase C19. Peptidase C19
                     contains ubiquitinyl hydrolases. They are intracellular
                     peptidases that remove ubiquitin molecules from
                     polyubiquinated peptides by cleavage of isopeptide bonds.
                     They hydrolyze bonds involving the carboxyl...; cd02663"
                     /db_xref="CDD:239128"
     CDS             1..312
                     /gene="USP12"
                     /gene_synonym="UBH1; USP12L1"
                     /coded_by="XM_005266282.3:173..1111"
                     /db_xref="GeneID:219333"
                     /db_xref="HGNC:HGNC:20485"
                     /db_xref="MIM:603091"
ORIGIN      
        1 meilmtvskf asictmgana salekeigpe qfpvnehyfg lvnfgntcyc nsvlqalyfc
       61 rpfrekvlay ksqprkkesl ltcladlfhs iatqkkkvgv ippkkfitrl rkenelfdny
      121 mqqdahefln yllntiadil qeerkqekqn grlpngnidn ennnstpdpt wvheifqgtl
      181 tnetrcltce tisskdedfl dlsvdveqnt sithclrgfs ntetlcseyk yyceecrskq
      241 eahkrmkvkk lpmilalhlk rfkymdqlhr ytklsyrvvf plelrlfnts gdatnpdrmy
      301 dlvavvvhcg rk
//
LOCUS       XP_006719834             278 aa            linear   PRI 05-AUG-2025
DEFINITION  translation initiation factor IF-3, mitochondrial isoform X1 [Homo
            sapiens].
ACCESSION   XP_006719834
VERSION     XP_006719834.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006719771.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..278
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..278
                     /product="translation initiation factor IF-3,
                     mitochondrial isoform X1"
                     /calculated_mol_wt=31594
     Region          78..146
                     /region_name="IF3_N"
                     /note="Translation initiation factor IF-3, N-terminal
                     domain; pfam05198"
                     /db_xref="CDD:461584"
     Region          81..237
                     /region_name="infC"
                     /note="translation initiation factor IF-3; TIGR00168"
                     /db_xref="CDD:129272"
     CDS             1..278
                     /gene="MTIF3"
                     /gene_synonym="IF3mt"
                     /coded_by="XM_006719771.4:639..1475"
                     /db_xref="GeneID:219402"
                     /db_xref="HGNC:HGNC:29788"
                     /db_xref="MIM:619554"
ORIGIN      
        1 maalflkrlt lqtvksensc ircfgkhilq ktapaqlspi asaprlsfli hakafstaed
       61 tqnegkktkk nktafsnvgr kisqrvihlf dekgndlgnm hranvirlmd erdlrlvqrn
      121 tstepaeyql mtglqilqer qrlremekan pktgptlrke lilssnigqh dldtktkqiq
      181 qwikkkhlvq itikkgknvd vsenemeeif hqilqtmpgi atfssrpqav qggkalmcvl
      241 rafskneeka yketqetqer dtlnkdhgnd kesnvlhq
//
LOCUS       XP_047286082             278 aa            linear   PRI 05-AUG-2025
DEFINITION  translation initiation factor IF-3, mitochondrial isoform X1 [Homo
            sapiens].
ACCESSION   XP_047286082
VERSION     XP_047286082.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430126.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..278
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..278
                     /product="translation initiation factor IF-3,
                     mitochondrial isoform X1"
                     /calculated_mol_wt=31594
     Region          78..146
                     /region_name="IF3_N"
                     /note="Translation initiation factor IF-3, N-terminal
                     domain; pfam05198"
                     /db_xref="CDD:461584"
     Region          81..237
                     /region_name="infC"
                     /note="translation initiation factor IF-3; TIGR00168"
                     /db_xref="CDD:129272"
     CDS             1..278
                     /gene="MTIF3"
                     /gene_synonym="IF3mt"
                     /coded_by="XM_047430126.1:561..1397"
                     /db_xref="GeneID:219402"
                     /db_xref="HGNC:HGNC:29788"
                     /db_xref="MIM:619554"
ORIGIN      
        1 maalflkrlt lqtvksensc ircfgkhilq ktapaqlspi asaprlsfli hakafstaed
       61 tqnegkktkk nktafsnvgr kisqrvihlf dekgndlgnm hranvirlmd erdlrlvqrn
      121 tstepaeyql mtglqilqer qrlremekan pktgptlrke lilssnigqh dldtktkqiq
      181 qwikkkhlvq itikkgknvd vsenemeeif hqilqtmpgi atfssrpqav qggkalmcvl
      241 rafskneeka yketqetqer dtlnkdhgnd kesnvlhq
//
LOCUS       XP_006719835             278 aa            linear   PRI 05-AUG-2025
DEFINITION  translation initiation factor IF-3, mitochondrial isoform X1 [Homo
            sapiens].
ACCESSION   XP_006719835
VERSION     XP_006719835.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006719772.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..278
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..278
                     /product="translation initiation factor IF-3,
                     mitochondrial isoform X1"
                     /calculated_mol_wt=31594
     Region          78..146
                     /region_name="IF3_N"
                     /note="Translation initiation factor IF-3, N-terminal
                     domain; pfam05198"
                     /db_xref="CDD:461584"
     Region          81..237
                     /region_name="infC"
                     /note="translation initiation factor IF-3; TIGR00168"
                     /db_xref="CDD:129272"
     CDS             1..278
                     /gene="MTIF3"
                     /gene_synonym="IF3mt"
                     /coded_by="XM_006719772.5:108..944"
                     /db_xref="GeneID:219402"
                     /db_xref="HGNC:HGNC:29788"
                     /db_xref="MIM:619554"
ORIGIN      
        1 maalflkrlt lqtvksensc ircfgkhilq ktapaqlspi asaprlsfli hakafstaed
       61 tqnegkktkk nktafsnvgr kisqrvihlf dekgndlgnm hranvirlmd erdlrlvqrn
      121 tstepaeyql mtglqilqer qrlremekan pktgptlrke lilssnigqh dldtktkqiq
      181 qwikkkhlvq itikkgknvd vsenemeeif hqilqtmpgi atfssrpqav qggkalmcvl
      241 rafskneeka yketqetqer dtlnkdhgnd kesnvlhq
//
LOCUS       XP_016875906             278 aa            linear   PRI 05-AUG-2025
DEFINITION  translation initiation factor IF-3, mitochondrial isoform X1 [Homo
            sapiens].
ACCESSION   XP_016875906
VERSION     XP_016875906.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020417.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..278
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..278
                     /product="translation initiation factor IF-3,
                     mitochondrial isoform X1"
                     /calculated_mol_wt=31594
     Region          78..146
                     /region_name="IF3_N"
                     /note="Translation initiation factor IF-3, N-terminal
                     domain; pfam05198"
                     /db_xref="CDD:461584"
     Region          81..237
                     /region_name="infC"
                     /note="translation initiation factor IF-3; TIGR00168"
                     /db_xref="CDD:129272"
     CDS             1..278
                     /gene="MTIF3"
                     /gene_synonym="IF3mt"
                     /coded_by="XM_017020417.2:553..1389"
                     /db_xref="GeneID:219402"
                     /db_xref="HGNC:HGNC:29788"
                     /db_xref="MIM:619554"
ORIGIN      
        1 maalflkrlt lqtvksensc ircfgkhilq ktapaqlspi asaprlsfli hakafstaed
       61 tqnegkktkk nktafsnvgr kisqrvihlf dekgndlgnm hranvirlmd erdlrlvqrn
      121 tstepaeyql mtglqilqer qrlremekan pktgptlrke lilssnigqh dldtktkqiq
      181 qwikkkhlvq itikkgknvd vsenemeeif hqilqtmpgi atfssrpqav qggkalmcvl
      241 rafskneeka yketqetqer dtlnkdhgnd kesnvlhq
//
LOCUS       XP_047286083             278 aa            linear   PRI 05-AUG-2025
DEFINITION  translation initiation factor IF-3, mitochondrial isoform X1 [Homo
            sapiens].
ACCESSION   XP_047286083
VERSION     XP_047286083.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430127.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..278
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..278
                     /product="translation initiation factor IF-3,
                     mitochondrial isoform X1"
                     /calculated_mol_wt=31594
     Region          78..146
                     /region_name="IF3_N"
                     /note="Translation initiation factor IF-3, N-terminal
                     domain; pfam05198"
                     /db_xref="CDD:461584"
     Region          81..237
                     /region_name="infC"
                     /note="translation initiation factor IF-3; TIGR00168"
                     /db_xref="CDD:129272"
     CDS             1..278
                     /gene="MTIF3"
                     /gene_synonym="IF3mt"
                     /coded_by="XM_047430127.1:475..1311"
                     /db_xref="GeneID:219402"
                     /db_xref="HGNC:HGNC:29788"
                     /db_xref="MIM:619554"
ORIGIN      
        1 maalflkrlt lqtvksensc ircfgkhilq ktapaqlspi asaprlsfli hakafstaed
       61 tqnegkktkk nktafsnvgr kisqrvihlf dekgndlgnm hranvirlmd erdlrlvqrn
      121 tstepaeyql mtglqilqer qrlremekan pktgptlrke lilssnigqh dldtktkqiq
      181 qwikkkhlvq itikkgknvd vsenemeeif hqilqtmpgi atfssrpqav qggkalmcvl
      241 rafskneeka yketqetqer dtlnkdhgnd kesnvlhq
//
LOCUS       XP_011533260             278 aa            linear   PRI 05-AUG-2025
DEFINITION  translation initiation factor IF-3, mitochondrial isoform X1 [Homo
            sapiens].
ACCESSION   XP_011533260
VERSION     XP_011533260.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534958.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..278
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..278
                     /product="translation initiation factor IF-3,
                     mitochondrial isoform X1"
                     /calculated_mol_wt=31594
     Region          78..146
                     /region_name="IF3_N"
                     /note="Translation initiation factor IF-3, N-terminal
                     domain; pfam05198"
                     /db_xref="CDD:461584"
     Region          81..237
                     /region_name="infC"
                     /note="translation initiation factor IF-3; TIGR00168"
                     /db_xref="CDD:129272"
     CDS             1..278
                     /gene="MTIF3"
                     /gene_synonym="IF3mt"
                     /coded_by="XM_011534958.4:633..1469"
                     /db_xref="GeneID:219402"
                     /db_xref="HGNC:HGNC:29788"
                     /db_xref="MIM:619554"
ORIGIN      
        1 maalflkrlt lqtvksensc ircfgkhilq ktapaqlspi asaprlsfli hakafstaed
       61 tqnegkktkk nktafsnvgr kisqrvihlf dekgndlgnm hranvirlmd erdlrlvqrn
      121 tstepaeyql mtglqilqer qrlremekan pktgptlrke lilssnigqh dldtktkqiq
      181 qwikkkhlvq itikkgknvd vsenemeeif hqilqtmpgi atfssrpqav qggkalmcvl
      241 rafskneeka yketqetqer dtlnkdhgnd kesnvlhq
//
LOCUS       XP_011533263             278 aa            linear   PRI 05-AUG-2025
DEFINITION  translation initiation factor IF-3, mitochondrial isoform X1 [Homo
            sapiens].
ACCESSION   XP_011533263
VERSION     XP_011533263.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534961.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..278
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..278
                     /product="translation initiation factor IF-3,
                     mitochondrial isoform X1"
                     /calculated_mol_wt=31594
     Region          78..146
                     /region_name="IF3_N"
                     /note="Translation initiation factor IF-3, N-terminal
                     domain; pfam05198"
                     /db_xref="CDD:461584"
     Region          81..237
                     /region_name="infC"
                     /note="translation initiation factor IF-3; TIGR00168"
                     /db_xref="CDD:129272"
     CDS             1..278
                     /gene="MTIF3"
                     /gene_synonym="IF3mt"
                     /coded_by="XM_011534961.4:555..1391"
                     /db_xref="GeneID:219402"
                     /db_xref="HGNC:HGNC:29788"
                     /db_xref="MIM:619554"
ORIGIN      
        1 maalflkrlt lqtvksensc ircfgkhilq ktapaqlspi asaprlsfli hakafstaed
       61 tqnegkktkk nktafsnvgr kisqrvihlf dekgndlgnm hranvirlmd erdlrlvqrn
      121 tstepaeyql mtglqilqer qrlremekan pktgptlrke lilssnigqh dldtktkqiq
      181 qwikkkhlvq itikkgknvd vsenemeeif hqilqtmpgi atfssrpqav qggkalmcvl
      241 rafskneeka yketqetqer dtlnkdhgnd kesnvlhq
//
LOCUS       XP_047286084             278 aa            linear   PRI 05-AUG-2025
DEFINITION  translation initiation factor IF-3, mitochondrial isoform X1 [Homo
            sapiens].
ACCESSION   XP_047286084
VERSION     XP_047286084.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430128.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..278
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..278
                     /product="translation initiation factor IF-3,
                     mitochondrial isoform X1"
                     /calculated_mol_wt=31594
     Region          78..146
                     /region_name="IF3_N"
                     /note="Translation initiation factor IF-3, N-terminal
                     domain; pfam05198"
                     /db_xref="CDD:461584"
     Region          81..237
                     /region_name="infC"
                     /note="translation initiation factor IF-3; TIGR00168"
                     /db_xref="CDD:129272"
     CDS             1..278
                     /gene="MTIF3"
                     /gene_synonym="IF3mt"
                     /coded_by="XM_047430128.1:169..1005"
                     /db_xref="GeneID:219402"
                     /db_xref="HGNC:HGNC:29788"
                     /db_xref="MIM:619554"
ORIGIN      
        1 maalflkrlt lqtvksensc ircfgkhilq ktapaqlspi asaprlsfli hakafstaed
       61 tqnegkktkk nktafsnvgr kisqrvihlf dekgndlgnm hranvirlmd erdlrlvqrn
      121 tstepaeyql mtglqilqer qrlremekan pktgptlrke lilssnigqh dldtktkqiq
      181 qwikkkhlvq itikkgknvd vsenemeeif hqilqtmpgi atfssrpqav qggkalmcvl
      241 rafskneeka yketqetqer dtlnkdhgnd kesnvlhq
//
LOCUS       XP_047286085             278 aa            linear   PRI 05-AUG-2025
DEFINITION  translation initiation factor IF-3, mitochondrial isoform X1 [Homo
            sapiens].
ACCESSION   XP_047286085
VERSION     XP_047286085.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430129.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 44% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..278
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..278
                     /product="translation initiation factor IF-3,
                     mitochondrial isoform X1"
                     /calculated_mol_wt=31594
     Region          78..146
                     /region_name="IF3_N"
                     /note="Translation initiation factor IF-3, N-terminal
                     domain; pfam05198"
                     /db_xref="CDD:461584"
     Region          81..237
                     /region_name="infC"
                     /note="translation initiation factor IF-3; TIGR00168"
                     /db_xref="CDD:129272"
     CDS             1..278
                     /gene="MTIF3"
                     /gene_synonym="IF3mt"
                     /coded_by="XM_047430129.1:620..1456"
                     /db_xref="GeneID:219402"
                     /db_xref="HGNC:HGNC:29788"
                     /db_xref="MIM:619554"
ORIGIN      
        1 maalflkrlt lqtvksensc ircfgkhilq ktapaqlspi asaprlsfli hakafstaed
       61 tqnegkktkk nktafsnvgr kisqrvihlf dekgndlgnm hranvirlmd erdlrlvqrn
      121 tstepaeyql mtglqilqer qrlremekan pktgptlrke lilssnigqh dldtktkqiq
      181 qwikkkhlvq itikkgknvd vsenemeeif hqilqtmpgi atfssrpqav qggkalmcvl
      241 rafskneeka yketqetqer dtlnkdhgnd kesnvlhq
//
LOCUS       XP_011533259             278 aa            linear   PRI 05-AUG-2025
DEFINITION  translation initiation factor IF-3, mitochondrial isoform X1 [Homo
            sapiens].
ACCESSION   XP_011533259
VERSION     XP_011533259.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534957.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..278
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..278
                     /product="translation initiation factor IF-3,
                     mitochondrial isoform X1"
                     /calculated_mol_wt=31594
     Region          78..146
                     /region_name="IF3_N"
                     /note="Translation initiation factor IF-3, N-terminal
                     domain; pfam05198"
                     /db_xref="CDD:461584"
     Region          81..237
                     /region_name="infC"
                     /note="translation initiation factor IF-3; TIGR00168"
                     /db_xref="CDD:129272"
     CDS             1..278
                     /gene="MTIF3"
                     /gene_synonym="IF3mt"
                     /coded_by="XM_011534957.4:353..1189"
                     /db_xref="GeneID:219402"
                     /db_xref="HGNC:HGNC:29788"
                     /db_xref="MIM:619554"
ORIGIN      
        1 maalflkrlt lqtvksensc ircfgkhilq ktapaqlspi asaprlsfli hakafstaed
       61 tqnegkktkk nktafsnvgr kisqrvihlf dekgndlgnm hranvirlmd erdlrlvqrn
      121 tstepaeyql mtglqilqer qrlremekan pktgptlrke lilssnigqh dldtktkqiq
      181 qwikkkhlvq itikkgknvd vsenemeeif hqilqtmpgi atfssrpqav qggkalmcvl
      241 rafskneeka yketqetqer dtlnkdhgnd kesnvlhq
//
LOCUS       XP_011533261             278 aa            linear   PRI 05-AUG-2025
DEFINITION  translation initiation factor IF-3, mitochondrial isoform X1 [Homo
            sapiens].
ACCESSION   XP_011533261
VERSION     XP_011533261.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534959.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..278
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..278
                     /product="translation initiation factor IF-3,
                     mitochondrial isoform X1"
                     /calculated_mol_wt=31594
     Region          78..146
                     /region_name="IF3_N"
                     /note="Translation initiation factor IF-3, N-terminal
                     domain; pfam05198"
                     /db_xref="CDD:461584"
     Region          81..237
                     /region_name="infC"
                     /note="translation initiation factor IF-3; TIGR00168"
                     /db_xref="CDD:129272"
     CDS             1..278
                     /gene="MTIF3"
                     /gene_synonym="IF3mt"
                     /coded_by="XM_011534959.4:798..1634"
                     /db_xref="GeneID:219402"
                     /db_xref="HGNC:HGNC:29788"
                     /db_xref="MIM:619554"
ORIGIN      
        1 maalflkrlt lqtvksensc ircfgkhilq ktapaqlspi asaprlsfli hakafstaed
       61 tqnegkktkk nktafsnvgr kisqrvihlf dekgndlgnm hranvirlmd erdlrlvqrn
      121 tstepaeyql mtglqilqer qrlremekan pktgptlrke lilssnigqh dldtktkqiq
      181 qwikkkhlvq itikkgknvd vsenemeeif hqilqtmpgi atfssrpqav qggkalmcvl
      241 rafskneeka yketqetqer dtlnkdhgnd kesnvlhq
//
LOCUS       XP_011533262             278 aa            linear   PRI 05-AUG-2025
DEFINITION  translation initiation factor IF-3, mitochondrial isoform X1 [Homo
            sapiens].
ACCESSION   XP_011533262
VERSION     XP_011533262.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534960.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..278
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..278
                     /product="translation initiation factor IF-3,
                     mitochondrial isoform X1"
                     /calculated_mol_wt=31594
     Region          78..146
                     /region_name="IF3_N"
                     /note="Translation initiation factor IF-3, N-terminal
                     domain; pfam05198"
                     /db_xref="CDD:461584"
     Region          81..237
                     /region_name="infC"
                     /note="translation initiation factor IF-3; TIGR00168"
                     /db_xref="CDD:129272"
     CDS             1..278
                     /gene="MTIF3"
                     /gene_synonym="IF3mt"
                     /coded_by="XM_011534960.3:288..1124"
                     /db_xref="GeneID:219402"
                     /db_xref="HGNC:HGNC:29788"
                     /db_xref="MIM:619554"
ORIGIN      
        1 maalflkrlt lqtvksensc ircfgkhilq ktapaqlspi asaprlsfli hakafstaed
       61 tqnegkktkk nktafsnvgr kisqrvihlf dekgndlgnm hranvirlmd erdlrlvqrn
      121 tstepaeyql mtglqilqer qrlremekan pktgptlrke lilssnigqh dldtktkqiq
      181 qwikkkhlvq itikkgknvd vsenemeeif hqilqtmpgi atfssrpqav qggkalmcvl
      241 rafskneeka yketqetqer dtlnkdhgnd kesnvlhq
//
LOCUS       XP_011533264             278 aa            linear   PRI 05-AUG-2025
DEFINITION  translation initiation factor IF-3, mitochondrial isoform X1 [Homo
            sapiens].
ACCESSION   XP_011533264
VERSION     XP_011533264.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534962.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..278
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..278
                     /product="translation initiation factor IF-3,
                     mitochondrial isoform X1"
                     /calculated_mol_wt=31594
     Region          78..146
                     /region_name="IF3_N"
                     /note="Translation initiation factor IF-3, N-terminal
                     domain; pfam05198"
                     /db_xref="CDD:461584"
     Region          81..237
                     /region_name="infC"
                     /note="translation initiation factor IF-3; TIGR00168"
                     /db_xref="CDD:129272"
     CDS             1..278
                     /gene="MTIF3"
                     /gene_synonym="IF3mt"
                     /coded_by="XM_011534962.3:453..1289"
                     /db_xref="GeneID:219402"
                     /db_xref="HGNC:HGNC:29788"
                     /db_xref="MIM:619554"
ORIGIN      
        1 maalflkrlt lqtvksensc ircfgkhilq ktapaqlspi asaprlsfli hakafstaed
       61 tqnegkktkk nktafsnvgr kisqrvihlf dekgndlgnm hranvirlmd erdlrlvqrn
      121 tstepaeyql mtglqilqer qrlremekan pktgptlrke lilssnigqh dldtktkqiq
      181 qwikkkhlvq itikkgknvd vsenemeeif hqilqtmpgi atfssrpqav qggkalmcvl
      241 rafskneeka yketqetqer dtlnkdhgnd kesnvlhq
//
LOCUS       XP_047286086             278 aa            linear   PRI 05-AUG-2025
DEFINITION  translation initiation factor IF-3, mitochondrial isoform X1 [Homo
            sapiens].
ACCESSION   XP_047286086
VERSION     XP_047286086.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430130.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..278
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..278
                     /product="translation initiation factor IF-3,
                     mitochondrial isoform X1"
                     /calculated_mol_wt=31594
     Region          78..146
                     /region_name="IF3_N"
                     /note="Translation initiation factor IF-3, N-terminal
                     domain; pfam05198"
                     /db_xref="CDD:461584"
     Region          81..237
                     /region_name="infC"
                     /note="translation initiation factor IF-3; TIGR00168"
                     /db_xref="CDD:129272"
     CDS             1..278
                     /gene="MTIF3"
                     /gene_synonym="IF3mt"
                     /coded_by="XM_047430130.1:542..1378"
                     /db_xref="GeneID:219402"
                     /db_xref="HGNC:HGNC:29788"
                     /db_xref="MIM:619554"
ORIGIN      
        1 maalflkrlt lqtvksensc ircfgkhilq ktapaqlspi asaprlsfli hakafstaed
       61 tqnegkktkk nktafsnvgr kisqrvihlf dekgndlgnm hranvirlmd erdlrlvqrn
      121 tstepaeyql mtglqilqer qrlremekan pktgptlrke lilssnigqh dldtktkqiq
      181 qwikkkhlvq itikkgknvd vsenemeeif hqilqtmpgi atfssrpqav qggkalmcvl
      241 rafskneeka yketqetqer dtlnkdhgnd kesnvlhq
//
LOCUS       XP_011533265             278 aa            linear   PRI 05-AUG-2025
DEFINITION  translation initiation factor IF-3, mitochondrial isoform X1 [Homo
            sapiens].
ACCESSION   XP_011533265
VERSION     XP_011533265.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534963.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..278
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..278
                     /product="translation initiation factor IF-3,
                     mitochondrial isoform X1"
                     /calculated_mol_wt=31594
     Region          78..146
                     /region_name="IF3_N"
                     /note="Translation initiation factor IF-3, N-terminal
                     domain; pfam05198"
                     /db_xref="CDD:461584"
     Region          81..237
                     /region_name="infC"
                     /note="translation initiation factor IF-3; TIGR00168"
                     /db_xref="CDD:129272"
     CDS             1..278
                     /gene="MTIF3"
                     /gene_synonym="IF3mt"
                     /coded_by="XM_011534963.4:720..1556"
                     /db_xref="GeneID:219402"
                     /db_xref="HGNC:HGNC:29788"
                     /db_xref="MIM:619554"
ORIGIN      
        1 maalflkrlt lqtvksensc ircfgkhilq ktapaqlspi asaprlsfli hakafstaed
       61 tqnegkktkk nktafsnvgr kisqrvihlf dekgndlgnm hranvirlmd erdlrlvqrn
      121 tstepaeyql mtglqilqer qrlremekan pktgptlrke lilssnigqh dldtktkqiq
      181 qwikkkhlvq itikkgknvd vsenemeeif hqilqtmpgi atfssrpqav qggkalmcvl
      241 rafskneeka yketqetqer dtlnkdhgnd kesnvlhq
//
LOCUS       XP_047286087             278 aa            linear   PRI 05-AUG-2025
DEFINITION  translation initiation factor IF-3, mitochondrial isoform X1 [Homo
            sapiens].
ACCESSION   XP_047286087
VERSION     XP_047286087.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430131.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..278
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..278
                     /product="translation initiation factor IF-3,
                     mitochondrial isoform X1"
                     /calculated_mol_wt=31594
     Region          78..146
                     /region_name="IF3_N"
                     /note="Translation initiation factor IF-3, N-terminal
                     domain; pfam05198"
                     /db_xref="CDD:461584"
     Region          81..237
                     /region_name="infC"
                     /note="translation initiation factor IF-3; TIGR00168"
                     /db_xref="CDD:129272"
     CDS             1..278
                     /gene="MTIF3"
                     /gene_synonym="IF3mt"
                     /coded_by="XM_047430131.1:614..1450"
                     /db_xref="GeneID:219402"
                     /db_xref="HGNC:HGNC:29788"
                     /db_xref="MIM:619554"
ORIGIN      
        1 maalflkrlt lqtvksensc ircfgkhilq ktapaqlspi asaprlsfli hakafstaed
       61 tqnegkktkk nktafsnvgr kisqrvihlf dekgndlgnm hranvirlmd erdlrlvqrn
      121 tstepaeyql mtglqilqer qrlremekan pktgptlrke lilssnigqh dldtktkqiq
      181 qwikkkhlvq itikkgknvd vsenemeeif hqilqtmpgi atfssrpqav qggkalmcvl
      241 rafskneeka yketqetqer dtlnkdhgnd kesnvlhq
//
LOCUS       XP_047286088             278 aa            linear   PRI 05-AUG-2025
DEFINITION  translation initiation factor IF-3, mitochondrial isoform X1 [Homo
            sapiens].
ACCESSION   XP_047286088
VERSION     XP_047286088.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430132.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..278
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..278
                     /product="translation initiation factor IF-3,
                     mitochondrial isoform X1"
                     /calculated_mol_wt=31594
     Region          78..146
                     /region_name="IF3_N"
                     /note="Translation initiation factor IF-3, N-terminal
                     domain; pfam05198"
                     /db_xref="CDD:461584"
     Region          81..237
                     /region_name="infC"
                     /note="translation initiation factor IF-3; TIGR00168"
                     /db_xref="CDD:129272"
     CDS             1..278
                     /gene="MTIF3"
                     /gene_synonym="IF3mt"
                     /coded_by="XM_047430132.1:701..1537"
                     /db_xref="GeneID:219402"
                     /db_xref="HGNC:HGNC:29788"
                     /db_xref="MIM:619554"
ORIGIN      
        1 maalflkrlt lqtvksensc ircfgkhilq ktapaqlspi asaprlsfli hakafstaed
       61 tqnegkktkk nktafsnvgr kisqrvihlf dekgndlgnm hranvirlmd erdlrlvqrn
      121 tstepaeyql mtglqilqer qrlremekan pktgptlrke lilssnigqh dldtktkqiq
      181 qwikkkhlvq itikkgknvd vsenemeeif hqilqtmpgi atfssrpqav qggkalmcvl
      241 rafskneeka yketqetqer dtlnkdhgnd kesnvlhq
//
LOCUS       XP_047286089             278 aa            linear   PRI 05-AUG-2025
DEFINITION  translation initiation factor IF-3, mitochondrial isoform X1 [Homo
            sapiens].
ACCESSION   XP_047286089
VERSION     XP_047286089.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430133.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..278
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..278
                     /product="translation initiation factor IF-3,
                     mitochondrial isoform X1"
                     /calculated_mol_wt=31594
     Region          78..146
                     /region_name="IF3_N"
                     /note="Translation initiation factor IF-3, N-terminal
                     domain; pfam05198"
                     /db_xref="CDD:461584"
     Region          81..237
                     /region_name="infC"
                     /note="translation initiation factor IF-3; TIGR00168"
                     /db_xref="CDD:129272"
     CDS             1..278
                     /gene="MTIF3"
                     /gene_synonym="IF3mt"
                     /coded_by="XM_047430133.1:536..1372"
                     /db_xref="GeneID:219402"
                     /db_xref="HGNC:HGNC:29788"
                     /db_xref="MIM:619554"
ORIGIN      
        1 maalflkrlt lqtvksensc ircfgkhilq ktapaqlspi asaprlsfli hakafstaed
       61 tqnegkktkk nktafsnvgr kisqrvihlf dekgndlgnm hranvirlmd erdlrlvqrn
      121 tstepaeyql mtglqilqer qrlremekan pktgptlrke lilssnigqh dldtktkqiq
      181 qwikkkhlvq itikkgknvd vsenemeeif hqilqtmpgi atfssrpqav qggkalmcvl
      241 rafskneeka yketqetqer dtlnkdhgnd kesnvlhq
//
LOCUS       XP_047286090             278 aa            linear   PRI 05-AUG-2025
DEFINITION  translation initiation factor IF-3, mitochondrial isoform X1 [Homo
            sapiens].
ACCESSION   XP_047286090
VERSION     XP_047286090.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430134.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..278
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..278
                     /product="translation initiation factor IF-3,
                     mitochondrial isoform X1"
                     /calculated_mol_wt=31594
     Region          78..146
                     /region_name="IF3_N"
                     /note="Translation initiation factor IF-3, N-terminal
                     domain; pfam05198"
                     /db_xref="CDD:461584"
     Region          81..237
                     /region_name="infC"
                     /note="translation initiation factor IF-3; TIGR00168"
                     /db_xref="CDD:129272"
     CDS             1..278
                     /gene="MTIF3"
                     /gene_synonym="IF3mt"
                     /coded_by="XM_047430134.1:413..1249"
                     /db_xref="GeneID:219402"
                     /db_xref="HGNC:HGNC:29788"
                     /db_xref="MIM:619554"
ORIGIN      
        1 maalflkrlt lqtvksensc ircfgkhilq ktapaqlspi asaprlsfli hakafstaed
       61 tqnegkktkk nktafsnvgr kisqrvihlf dekgndlgnm hranvirlmd erdlrlvqrn
      121 tstepaeyql mtglqilqer qrlremekan pktgptlrke lilssnigqh dldtktkqiq
      181 qwikkkhlvq itikkgknvd vsenemeeif hqilqtmpgi atfssrpqav qggkalmcvl
      241 rafskneeka yketqetqer dtlnkdhgnd kesnvlhq
//
LOCUS       XP_011533267             720 aa            linear   PRI 05-AUG-2025
DEFINITION  glutamate-rich protein 6B isoform X1 [Homo sapiens].
ACCESSION   XP_011533267
VERSION     XP_011533267.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534965.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..720
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..720
                     /product="glutamate-rich protein 6B isoform X1"
                     /calculated_mol_wt=84622
     Region          472..697
                     /region_name="FAM194"
                     /note="FAM194 protein; pfam14977"
                     /db_xref="CDD:464417"
     CDS             1..720
                     /gene="ERICH6B"
                     /gene_synonym="FAM194B"
                     /coded_by="XM_011534965.3:113..2275"
                     /db_xref="GeneID:220081"
                     /db_xref="HGNC:HGNC:26523"
ORIGIN      
        1 msaennqlsg aspphppttp qystqnlpse kedtevelde eslqdespfs pegesledke
       61 yleeeedlee eeylgkeeyl keeeylgkee hleeeeylek agyleeeeyi eeeeylgkeg
      121 yleeeeylgk eehleeeeyl gkegyleked yieevdylgk kayleeeeyl gkksyleeek
      181 alekeenlee eealekeenl dgkenlykky lkepkasyss qtmllrdars pdagpsqvtt
      241 fltvpltfat pspvsesate ssellltlyr rsqasqtdwc ydrtavkslk skseteqett
      301 tklapeehvn tkvqqkkeen vlefaskenf wdgitdesid klevedlden flnssyqtvf
      361 ktiikemaah neleedfdip ltkllesenr wklvimlkkn yekfketilr ikrrreaqkl
      421 temtsftfhl mskptpekpe teeiqkpqrv vhhrkklerd kewiqkktvv hqgdgklily
      481 pnknvyqilf pdgtgqiqyp qkhrdaridi ywhlkclrff mgypsgnlam lilyakmkkf
      541 tyiiledsle griralinns gnatfydens diwlnlssnl gyyfpkdkrq kawnwwnlni
      601 hvhappvqpi slkineyiqv qirsqdkiif cftyeqkqic lnlgtrykfv ipevlsemkk
      661 ktileaepgp taqkirvllg kmnrllnyat tpdlenfiea vsislmdnky lkkmlsklwf
//
LOCUS       XP_016875907             696 aa            linear   PRI 05-AUG-2025
DEFINITION  glutamate-rich protein 6B isoform X2 [Homo sapiens].
ACCESSION   XP_016875907
VERSION     XP_016875907.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020418.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..696
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..696
                     /product="glutamate-rich protein 6B isoform X2"
                     /calculated_mol_wt=81555
     Region          472..673
                     /region_name="FAM194"
                     /note="FAM194 protein; pfam14977"
                     /db_xref="CDD:464417"
     CDS             1..696
                     /gene="ERICH6B"
                     /gene_synonym="FAM194B"
                     /coded_by="XM_017020418.2:113..2203"
                     /db_xref="GeneID:220081"
                     /db_xref="HGNC:HGNC:26523"
ORIGIN      
        1 msaennqlsg aspphppttp qystqnlpse kedtevelde eslqdespfs pegesledke
       61 yleeeedlee eeylgkeeyl keeeylgkee hleeeeylek agyleeeeyi eeeeylgkeg
      121 yleeeeylgk eehleeeeyl gkegyleked yieevdylgk kayleeeeyl gkksyleeek
      181 alekeenlee eealekeenl dgkenlykky lkepkasyss qtmllrdars pdagpsqvtt
      241 fltvpltfat pspvsesate ssellltlyr rsqasqtdwc ydrtavkslk skseteqett
      301 tklapeehvn tkvqqkkeen vlefaskenf wdgitdesid klevedlden flnssyqtvf
      361 ktiikemaah neleedfdip ltkllesenr wklvimlkkn yekfketilr ikrrreaqkl
      421 temtsftfhl mskptpekpe teeiqkpqrv vhhrkklerd kewiqkktvv hqgdgklily
      481 pnknvyqilf pdgtgqihyp sgnlamlily akmkkftyii ledslegrir alinnsgnat
      541 fydensdiwl nlssnlgyyf pkdkrqkawn wwnlnihvha ppvqpislki neyiqvqirs
      601 qdkiifcfty eqkqiclnlg trykfvipev lsemkkktil eaepgptaqk irvllgkmnr
      661 llnyattpdl enfieavsis lmdnkylkkm lsklwf
//
LOCUS       XP_011533273             475 aa            linear   PRI 05-AUG-2025
DEFINITION  protein chibby homolog 2 isoform X1 [Homo sapiens].
ACCESSION   XP_011533273
VERSION     XP_011533273.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534971.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..475
                     /product="protein chibby homolog 2 isoform X1"
                     /calculated_mol_wt=54575
     Region          104..219
                     /region_name="Cby_like"
                     /note="Chibby, a nuclear inhibitor of Wnt/beta-catenin
                     mediated transcription, and similar proteins; cd07429"
                     /db_xref="CDD:143631"
     Region          <195..>432
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..475
                     /gene="CBY2"
                     /gene_synonym="NURIT; SPERT"
                     /coded_by="XM_011534971.3:72..1499"
                     /db_xref="GeneID:220082"
                     /db_xref="HGNC:HGNC:30720"
                     /db_xref="MIM:618614"
ORIGIN      
        1 msplecsecf gdqllhrtyt wqltlhsrpn ytrkrdtrse sleipisvvl pqshlsphwk
       61 tramqpeglk crmeesnaer gtaepfprlh nlystprcaq qaalprlsrr masqhsypln
      121 rfssvpldpm erpmsqadle ldynpprvql sdemfvfqdg rwvnencrlq spyfspsasf
      181 hhklhhkrla kecmlqeenk slreenkalr eenrmlsken kilqvfweeh kaslgreesr
      241 apspllhkds aslevvkkdh valqvprgke dstlqllree nralqqlleq kqaywaqaed
      301 taapaeeskp apspheepcs pgllqdqgsg lssrfeepkg pparqedske lralrkmvsn
      361 msgpsgeeea kvgpglpdgc qplqllremr qalqallken rllqeenrtl qvlraehrgf
      421 qeenkalwen nklklqqklv idtvtevtar memlieelya fmparsqdpk kpsrv
//
LOCUS       XP_047286091             365 aa            linear   PRI 05-AUG-2025
DEFINITION  protein chibby homolog 2 isoform X2 [Homo sapiens].
ACCESSION   XP_047286091
VERSION     XP_047286091.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430135.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..365
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..365
                     /product="protein chibby homolog 2 isoform X2"
                     /calculated_mol_wt=41777
     Region          1..109
                     /region_name="Cby_like"
                     /note="Chibby, a nuclear inhibitor of Wnt/beta-catenin
                     mediated transcription, and similar proteins; cd07429"
                     /db_xref="CDD:143631"
     Region          <281..>340
                     /region_name="MreC"
                     /note="rod shape-determining protein MreC; cl46468"
                     /db_xref="CDD:480808"
     CDS             1..365
                     /gene="CBY2"
                     /gene_synonym="NURIT; SPERT"
                     /coded_by="XM_047430135.1:198..1295"
                     /db_xref="GeneID:220082"
                     /db_xref="HGNC:HGNC:30720"
                     /db_xref="MIM:618614"
ORIGIN      
        1 masqhsypln rfssvpldpm erpmsqadle ldynpprvql sdemfvfqdg rwvnencrlq
       61 spyfspsasf hhklhhkrla kecmlqeenk slreenkalr eenrmlsken kilqvfweeh
      121 kaslgreesr apspllhkds aslevvkkdh valqvprgke dstlqllree nralqqlleq
      181 kqaywaqaed taapaeeskp apspheepcs pgllqdqgsg lssrfeepkg pparqedske
      241 lralrkmvsn msgpsgeeea kvgpglpdgc qplqllremr qalqallken rllqeenrtl
      301 qvlraehrgf qeenkalwen nklklqqklv idtvtevtar memlieelya fmparsqdpk
      361 kpsrv
//
LOCUS       XP_011533280             339 aa            linear   PRI 05-AUG-2025
DEFINITION  protein FAM124A isoform X1 [Homo sapiens].
ACCESSION   XP_011533280
VERSION     XP_011533280.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534978.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..339
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..339
                     /product="protein FAM124A isoform X1"
                     /calculated_mol_wt=38188
     Region          83..314
                     /region_name="FAM124"
                     /note="FAM124 family; pfam15067"
                     /db_xref="CDD:464482"
     CDS             1..339
                     /gene="FAM124A"
                     /coded_by="XM_011534978.3:105..1124"
                     /db_xref="GeneID:220108"
                     /db_xref="HGNC:HGNC:26413"
ORIGIN      
        1 mdpkagggge eddcvdsgae tggsdyshls stsngfstwr mpcclflyct hgdkekgrws
       61 lqvehtwpsg elsveeaqdp flvsihiiad pgesqplqea idnvlawihp dlplfrvser
      121 rasrrrrkpp kgaqpalavv lflqeeygee qilqlhrtlq qppwrhhhte qvhgrflpyl
      181 pcsqdfftla pgtplwairp vhygkeivrf tvycrydnya dslrfyqlil rrspsqkkad
      241 fcifpifsnl dvdiqfslkr lpcdqcpvpt dssvlefrvr digelvpllp npcspisegr
      301 wqtedhdgnk illqdgplsc lhllatvnnt amnvgtkga
//
LOCUS       XP_016875908             303 aa            linear   PRI 05-AUG-2025
DEFINITION  protein FAM124A isoform X2 [Homo sapiens].
ACCESSION   XP_016875908
VERSION     XP_016875908.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020419.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..303
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..303
                     /product="protein FAM124A isoform X2"
                     /calculated_mol_wt=33934
     Region          47..278
                     /region_name="FAM124"
                     /note="FAM124 family; pfam15067"
                     /db_xref="CDD:464482"
     CDS             1..303
                     /gene="FAM124A"
                     /coded_by="XM_017020419.3:105..1016"
                     /db_xref="GeneID:220108"
                     /db_xref="HGNC:HGNC:26413"
ORIGIN      
        1 mdpkagggge eddcvdsgae tggsdyshls stsselsvee aqdpflvsih iiadpgesqp
       61 lqeaidnvla wihpdlplfr vserrasrrr rkppkgaqpa lavvlflqee ygeeqilqlh
      121 rtlqqppwrh hhteqvhgrf lpylpcsqdf ftlapgtplw airpvhygke ivrftvycry
      181 dnyadslrfy qlilrrspsq kkadfcifpi fsnldvdiqf slkrlpcdqc pvptdssvle
      241 frvrdigelv pllpnpcspi segrwqtedh dgnkillqdg plsclhllat vnntamnvgt
      301 kga
//
LOCUS       XP_047286092             289 aa            linear   PRI 05-AUG-2025
DEFINITION  protein FAM124A isoform X3 [Homo sapiens].
ACCESSION   XP_047286092
VERSION     XP_047286092.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430136.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..289
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..289
                     /product="protein FAM124A isoform X3"
                     /calculated_mol_wt=32536
     Region          47..278
                     /region_name="FAM124"
                     /note="FAM124 family; pfam15067"
                     /db_xref="CDD:464482"
     CDS             1..289
                     /gene="FAM124A"
                     /coded_by="XM_047430136.1:105..974"
                     /db_xref="GeneID:220108"
                     /db_xref="HGNC:HGNC:26413"
ORIGIN      
        1 mdpkagggge eddcvdsgae tggsdyshls stsselsvee aqdpflvsih iiadpgesqp
       61 lqeaidnvla wihpdlplfr vserrasrrr rkppkgaqpa lavvlflqee ygeeqilqlh
      121 rtlqqppwrh hhteqvhgrf lpylpcsqdf ftlapgtplw airpvhygke ivrftvycry
      181 dnyadslrfy qlilrrspsq kkadfcifpi fsnldvdiqf slkrlpcdqc pvptdssvle
      241 frvrdigelv pllpnpcspi segrwqtedh dgnkillqgq ehstalage
//
LOCUS       XP_047286093             587 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 63 isoform X1 [Homo
            sapiens].
ACCESSION   XP_047286093
VERSION     XP_047286093.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430137.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 16% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..587
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..587
                     /product="leucine-rich repeat-containing protein 63
                     isoform X1"
                     /calculated_mol_wt=67032
     Region          306..>469
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          347..369
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          370..392
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          393..415
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          416..438
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          439..458
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          464..486
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     CDS             1..587
                     /gene="LRRC63"
                     /coded_by="XM_047430137.1:158..1921"
                     /db_xref="GeneID:220416"
                     /db_xref="HGNC:HGNC:34296"
ORIGIN      
        1 mqkpplllrr plppkftkls lhekkthtak tgkieslhva ftedettsik mdrtrfpdvl
       61 rnqsltpini qnifldhcvq ervtaisspq kstkhvreqi pdtatgsiff phcnsastri
      121 fgkqtnkmes srkfktmkdv ytekrlenil ilsskfskpk stpgsviaqk lekmhpkhqp
      181 lpespgytyq hisrdlsatv pspppmtvsm kpegqwpehf kstatltlrv tefpgfvslp
      241 tpvlprkphr qsvietlvte ngniesvpkq ipprppeglt ktekieseih vvrgegfktv
      301 aatryetita mtnlaivncq vygrnalnlk gffilncpdl tplafqliyl nlsfndlhyf
      361 pteilclknl qilklrnnpi keipseiqql eflriftiaf nlitvlpigl fslsyleeld
      421 vsyneltfip neiqklrsle kltvdgnels ffphgilkln ltkiqfennf thpcfwrdny
      481 lnnpqqltqi islfivqnkl hkfydkipve vqkllkctsr cewchgpkfg egfrvirscd
      541 ifgasqlpvm fyvcspscyr rikessfvld gspsrriald velskel
//
LOCUS       XP_016875911             575 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 63 isoform X2 [Homo
            sapiens].
ACCESSION   XP_016875911
VERSION     XP_016875911.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020422.2
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 25% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..575
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..575
                     /product="leucine-rich repeat-containing protein 63
                     isoform X2"
                     /calculated_mol_wt=65502
     Region          294..>457
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          335..357
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          358..380
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          381..403
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          404..426
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          427..446
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          452..474
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     CDS             1..575
                     /gene="LRRC63"
                     /coded_by="XM_017020422.2:284..2011"
                     /db_xref="GeneID:220416"
                     /db_xref="HGNC:HGNC:34296"
ORIGIN      
        1 mtreytlsac vqlsfgaktg kieslhvaft edettsikmd rtrfpdvlrn qsltpiniqn
       61 ifldhcvqer vtaisspqks tkhvreqipd tatgsiffph cnsastrifg kqtnkmessr
      121 kfktmkdvyt ekrlenilil sskfskpkst pgsviaqkle kmhpkhqplp espgytyqhi
      181 srdlsatvps pppmtvsmkp egqwpehfks tatltlrvte fpgfvslptp vlprkphrqs
      241 vietlvteng niesvpkqip prppegltkt ekieseihvv rgegfktvaa tryetitamt
      301 nlaivncqvy grnalnlkgf filncpdltp lafqliylnl sfndlhyfpt eilclknlqi
      361 lklrnnpike ipseiqqlef lriftiafnl itvlpiglfs lsyleeldvs yneltfipne
      421 iqklrslekl tvdgnelsff phgilklnlt kiqfennfth pcfwrdnyln npqqltqiis
      481 lfivqnklhk fydkipvevq kllkctsrce wchgpkfgeg frvirscdif gasqlpvmfy
      541 vcspscyrri kessfvldgs psrrialdve lskel
//
LOCUS       XP_016875912             537 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 63 isoform X3 [Homo
            sapiens].
ACCESSION   XP_016875912
VERSION     XP_016875912.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020423.2
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 27% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..537
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..537
                     /product="leucine-rich repeat-containing protein 63
                     isoform X3"
                     /calculated_mol_wt=61326
     Region          256..>419
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          297..319
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          320..342
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          343..365
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          366..388
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          389..408
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          414..436
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     CDS             1..537
                     /gene="LRRC63"
                     /coded_by="XM_017020423.2:822..2435"
                     /db_xref="GeneID:220416"
                     /db_xref="HGNC:HGNC:34296"
ORIGIN      
        1 mdrtrfpdvl rnqsltpini qnifldhcvq ervtaisspq kstkhvreqi pdtatgsiff
       61 phcnsastri fgkqtnkmes srkfktmkdv ytekrlenil ilsskfskpk stpgsviaqk
      121 lekmhpkhqp lpespgytyq hisrdlsatv pspppmtvsm kpegqwpehf kstatltlrv
      181 tefpgfvslp tpvlprkphr qsvietlvte ngniesvpkq ipprppeglt ktekieseih
      241 vvrgegfktv aatryetita mtnlaivncq vygrnalnlk gffilncpdl tplafqliyl
      301 nlsfndlhyf pteilclknl qilklrnnpi keipseiqql eflriftiaf nlitvlpigl
      361 fslsyleeld vsyneltfip neiqklrsle kltvdgnels ffphgilkln ltkiqfennf
      421 thpcfwrdny lnnpqqltqi islfivqnkl hkfydkipve vqkllkctsr cewchgpkfg
      481 egfrvirscd ifgasqlpvm fyvcspscyr rikessfvld gspsrriald velskel
//
LOCUS       XP_011533291             376 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 63 isoform X4 [Homo
            sapiens].
ACCESSION   XP_011533291
VERSION     XP_011533291.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534989.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..376
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..376
                     /product="leucine-rich repeat-containing protein 63
                     isoform X4"
                     /calculated_mol_wt=42371
     CDS             1..376
                     /gene="LRRC63"
                     /coded_by="XM_011534989.3:158..1288"
                     /db_xref="GeneID:220416"
                     /db_xref="HGNC:HGNC:34296"
ORIGIN      
        1 mqkpplllrr plppkftkls lhekkthtak tgkieslhva ftedettsik mdrtrfpdvl
       61 rnqsltpini qnifldhcvq ervtaisspq kstkhvreqi pdtatgsiff phcnsastri
      121 fgkqtnkmes srkfktmkdv ytekrlenil ilsskfskpk stpgsviaqk lekmhpkhqp
      181 lpespgytyq hisrdlsatv pspppmtvsm kpegqwpehf kstatltlrv tefpgfvslp
      241 tpvlprkphr qsvietlvte ngniesvpkq ipprppeglt ktekieseih vvrgegfktv
      301 aatryetita mtnlaivncq vygrnalnlk gffilncpdl tplafqliyl nlsfndlhyf
      361 ptemeegshe srneaa
//
LOCUS       XP_011533294             365 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 63 isoform X5 [Homo
            sapiens].
ACCESSION   XP_011533294
VERSION     XP_011533294.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534992.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..365
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..365
                     /product="leucine-rich repeat-containing protein 63
                     isoform X5"
                     /calculated_mol_wt=41157
     CDS             1..365
                     /gene="LRRC63"
                     /coded_by="XM_011534992.3:158..1255"
                     /db_xref="GeneID:220416"
                     /db_xref="HGNC:HGNC:34296"
ORIGIN      
        1 mqkpplllrr plppkftkls lhekkthtak tgkieslhva ftedettsik mdrtrfpdvl
       61 rnqsltpini qnifldhcvq ervtaisspq kstkhvreqi pdtatgsiff phcnsastri
      121 fgkqtnkmes srkfktmkdv ytekrlenil ilsskfskpk stpgsviaqk lekmhpkhqp
      181 lpespgytyq hisrdlsatv pspppmtvsm kpegqwpehf kstatltlrv tefpgfvslp
      241 tpvlprkphr qsvietlvte ngniesvpkq ipprppeglt ktekieseih vvrgegfktv
      301 aatryetita mtnlaivncq vygrnalnlk gffilncpdl tplafqliyl nlsfndlhyf
      361 pteit
//
LOCUS       XP_011533295             334 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 63 isoform X6 [Homo
            sapiens].
ACCESSION   XP_011533295
VERSION     XP_011533295.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534993.2
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 44% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..334
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..334
                     /product="leucine-rich repeat-containing protein 63
                     isoform X6"
                     /calculated_mol_wt=37561
     CDS             1..334
                     /gene="LRRC63"
                     /coded_by="XM_011534993.2:158..1162"
                     /db_xref="GeneID:220416"
                     /db_xref="HGNC:HGNC:34296"
ORIGIN      
        1 mqkpplllrr plppkftkls lhekkthtak tgkieslhva ftedettsik mdrtrfpdvl
       61 rnqsltpini qnifldhcvq ervtaisspq kstkhvreqi pdtatgsiff phcnsastri
      121 fgkqtnkmes srkfktmkdv ytekrlenil ilsskfskpk stpgsviaqk lekmhpkhqp
      181 lpespgytyq hisrdlsatv pspppmtvsm kpegqwpehf kstatltlrv tefpgfvslp
      241 tpvlprkphr qsvietlvte ngniesvpkq ipprppeglt ktekieseih vvrgegfktv
      301 aatryetita mtnlaivncq vygrnalnlk hiqv
//
LOCUS       XP_047286096             361 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 63 isoform X7 [Homo
            sapiens].
ACCESSION   XP_047286096
VERSION     XP_047286096.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430140.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 40% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..361
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..361
                     /product="leucine-rich repeat-containing protein 63
                     isoform X7"
                     /calculated_mol_wt=41517
     Region          80..>243
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          121..143
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          144..166
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          167..189
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          190..212
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          213..232
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     CDS             1..361
                     /gene="LRRC63"
                     /coded_by="XM_047430140.1:158..1243"
                     /db_xref="GeneID:220416"
                     /db_xref="HGNC:HGNC:34296"
ORIGIN      
        1 mqkpplllrr plppkftkls lhekkthtet lvtengnies vpkqipprpp egltktekie
       61 seihvvrgeg fktvaatrye titamtnlai vncqvygrna lnlkgffiln cpdltplafq
      121 liylnlsfnd lhyfpteilc lknlqilklr nnpikeipse iqqleflrif tiafnlitvl
      181 piglfslsyl eeldvsynel tfipneiqkl rslekltvdg nelsffphgi lklnltkiqf
      241 ennfthpcfw rdnylnnpqq ltqiislfiv qnklhkfydk ipvevqkllk ctsrcewchg
      301 pkfgegfrvi rscdifgasq lpvmfyvcsp scyrrikess fvldgspsrr ialdvelske
      361 l
//
LOCUS       XP_016875920             349 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 63 isoform X8 [Homo
            sapiens].
ACCESSION   XP_016875920
VERSION     XP_016875920.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020431.2
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 42% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..349
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..349
                     /product="leucine-rich repeat-containing protein 63
                     isoform X8"
                     /calculated_mol_wt=39987
     Region          68..>231
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          109..131
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          132..154
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          155..177
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          178..200
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          201..220
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     CDS             1..349
                     /gene="LRRC63"
                     /coded_by="XM_017020431.2:284..1333"
                     /db_xref="GeneID:220416"
                     /db_xref="HGNC:HGNC:34296"
ORIGIN      
        1 mtreytlsac vqlsfgetlv tengniesvp kqipprppeg ltktekiese ihvvrgegfk
       61 tvaatryeti tamtnlaivn cqvygrnaln lkgffilncp dltplafqli ylnlsfndlh
      121 yfpteilclk nlqilklrnn pikeipseiq qleflrifti afnlitvlpi glfslsylee
      181 ldvsyneltf ipneiqklrs lekltvdgne lsffphgilk lnltkiqfen nfthpcfwrd
      241 nylnnpqqlt qiislfivqn klhkfydkip vevqkllkct srcewchgpk fgegfrvirs
      301 cdifgasqlp vmfyvcspsc yrrikessfv ldgspsrria ldvelskel
//
LOCUS       XP_016875921             214 aa            linear   PRI 05-AUG-2025
DEFINITION  EEF1A lysine methyltransferase 1 isoform X1 [Homo sapiens].
ACCESSION   XP_016875921
VERSION     XP_016875921.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020432.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..214
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..214
                     /product="EEF1A lysine methyltransferase 1 isoform X1"
                     /calculated_mol_wt=24375
     Region          49..161
                     /region_name="N6-adenineMlase"
                     /note="Probable N6-adenine methyltransferase; pfam10237"
                     /db_xref="CDD:463014"
     CDS             1..214
                     /gene="EEF1AKMT1"
                     /gene_synonym="eEF1A-KMT; ESP13; N6AMT2"
                     /coded_by="XM_017020432.2:158..802"
                     /db_xref="GeneID:221143"
                     /db_xref="HGNC:HGNC:27351"
                     /db_xref="MIM:617793"
ORIGIN      
        1 msdleddetp qlsahalaal qefyaeqkqq iepgeddkyn igiieenwql sqfwysqeta
       61 lqlaqeaiaa vgeggriacv sapsvyqklr elcrenfsiy ifeydkrfam ygeefifydy
      121 nnpldlperi aahsfdivia dppylseecl rktsetvkyl trgkillctg aimeeqaael
      181 lgvkmctfvp rhtrnlanef rcyvnydsgl dcgi
//
LOCUS       XP_011533296             372 aa            linear   PRI 05-AUG-2025
DEFINITION  spindle and kinetochore-associated protein 3 isoform X1 [Homo
            sapiens].
ACCESSION   XP_011533296
VERSION     XP_011533296.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534994.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..372
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..372
                     /product="spindle and kinetochore-associated protein 3
                     isoform X1"
                     /calculated_mol_wt=41709
     Region          <1..61
                     /region_name="SKA3_N"
                     /note="Spindle and kinetochore-associated protein 3,
                     N-terminal domain; cd12957"
                     /db_xref="CDD:240570"
     CDS             1..372
                     /gene="SKA3"
                     /gene_synonym="C13orf3; RAMA1"
                     /coded_by="XM_011534994.3:49..1167"
                     /db_xref="GeneID:221150"
                     /db_xref="HGNC:HGNC:20262"
                     /db_xref="MIM:619247"
ORIGIN      
        1 mrilydlhse vqtlkddvni lldkarlenq egidfikatk vlmeknsmdi mkireyfqky
       61 gysprvkkns vheqeainsd pelsncenfq ktdvkddlsd ppvasscise ksprspqlsd
      121 fgleryivsq vlpnppqavn nykeepvivt pptkqslvkv lktpkcalkm ddfecvtpkl
      181 ehfgiseytm clnedytmgl knarnnksee aidtesrlnd nvfatpspii qqleksdaey
      241 tnsplvptfc tpglkipstk nsialvstny plsktnsssn dlevedrtsl vlnsdtcfen
      301 ltdpssptis syenllrtpt ppevtkiped ilqllskyns nlatpiaika vppskrflkh
      361 gqnirdvsnk en
//
LOCUS       XP_005266345             330 aa            linear   PRI 05-AUG-2025
DEFINITION  spindle and kinetochore-associated protein 3 isoform X2 [Homo
            sapiens].
ACCESSION   XP_005266345
VERSION     XP_005266345.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266288.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..330
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..330
                     /product="spindle and kinetochore-associated protein 3
                     isoform X2"
                     /calculated_mol_wt=36828
     Region          <1..19
                     /region_name="SKA3_N"
                     /note="Spindle and kinetochore-associated protein 3,
                     N-terminal domain; cd12957"
                     /db_xref="CDD:240570"
     CDS             1..330
                     /gene="SKA3"
                     /gene_synonym="C13orf3; RAMA1"
                     /coded_by="XM_005266288.5:260..1252"
                     /db_xref="GeneID:221150"
                     /db_xref="HGNC:HGNC:20262"
                     /db_xref="MIM:619247"
ORIGIN      
        1 meknsmdimk ireyfqkygy sprvkknsvh eqeainsdpe lsncenfqkt dvkddlsdpp
       61 vassciseks prspqlsdfg leryivsqvl pnppqavnny keepvivtpp tkqslvkvlk
      121 tpkcalkmdd fecvtpkleh fgiseytmcl nedytmglkn arnnkseeai dtesrlndnv
      181 fatpspiiqq leksdaeytn splvptfctp glkipstkns ialvstnypl sktnsssndl
      241 evedrtslvl nsdtcfenlt dpssptissy enllrtptpp evtkipedil qllskynsnl
      301 atpiaikavp pskrflkhgq nirdvsnken
//
LOCUS       XP_047286097             403 aa            linear   PRI 05-AUG-2025
DEFINITION  calcium uptake protein 2, mitochondrial isoform X1 [Homo sapiens].
ACCESSION   XP_047286097
VERSION     XP_047286097.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430141.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..403
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..403
                     /product="calcium uptake protein 2, mitochondrial isoform
                     X1"
                     /calculated_mol_wt=45333
     Region          176..>356
                     /region_name="EFh_MICU"
                     /note="EF-hand, calcium binding motif, found in
                     mitochondrial calcium uptake proteins MICU1, MICU2, MICU3,
                     and similar proteins; cl28896"
                     /db_xref="CDD:333716"
     Region          176..205
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320080"
     Region          233..263
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320080"
     Region          329..356
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320080"
     CDS             1..403
                     /gene="MICU2"
                     /gene_synonym="1110008L20Rik; EFHA1; hMICU3"
                     /coded_by="XM_047430141.1:23..1234"
                     /db_xref="GeneID:221154"
                     /db_xref="HGNC:HGNC:31830"
                     /db_xref="MIM:610632"
ORIGIN      
        1 maaaagscar vaawggklrr glavsrqavr spgplaaava gaalagagaa whhsrvsvaa
       61 rdgsftvsaq knvehgiiyi gkpslrkqrf mqfssleheg eyymtprdfl fsvmfeqmer
      121 ktsvkkltkk diedtlsgiq tagcgstffr dlgdkglisy teylflltil tkphsgfhva
      181 fkmldtdgne miekreffkl qkiiskqddl mtvktnetgy qeaivkepei nttlqmrffg
      241 krgqrklhyk efrrfmenlq teiqemeflq fskglsfmrk edfaewllff tntenkdiyw
      301 knvreklsag esisldefks fchftthled faiamqmfsl ahrpvrlegr rpgmvahacn
      361 pstlgvqggr itksgvqdqp gqhgetpsll kiqklagrgg rrl
//
LOCUS       XP_047286098             344 aa            linear   PRI 05-AUG-2025
DEFINITION  calcium uptake protein 2, mitochondrial isoform X2 [Homo sapiens].
ACCESSION   XP_047286098
VERSION     XP_047286098.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430142.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 13% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..344
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..344
                     /product="calcium uptake protein 2, mitochondrial isoform
                     X2"
                     /calculated_mol_wt=40420
     Region          86..305
                     /region_name="EFh_MICU2"
                     /note="EF-hand, calcium binding motif, found in calcium
                     uptake protein 2, mitochondrial (MICU2) and similar
                     proteins; cd16174"
                     /db_xref="CDD:320082"
     Region          86..115
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320082"
     Site            order(95,97,99,106,285,287,289,296)
                     /site_type="other"
                     /note="Ca binding site [ion binding]"
                     /db_xref="CDD:320082"
     Region          143..173
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320082"
     Region          239..268
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320082"
     Region          276..305
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320082"
     CDS             1..344
                     /gene="MICU2"
                     /gene_synonym="1110008L20Rik; EFHA1; hMICU3"
                     /coded_by="XM_047430142.1:368..1402"
                     /db_xref="GeneID:221154"
                     /db_xref="HGNC:HGNC:31830"
                     /db_xref="MIM:610632"
ORIGIN      
        1 mqfssleheg eyymtprdfl fsvmfeqmer ktsvkkltkk diedtlsgiq tagcgstffr
       61 dlgdkglisy teylflltil tkphsgfhva fkmldtdgne miekreffkl qkiiskqddl
      121 mtvktnetgy qeaivkepei nttlqmrffg krgqrklhyk efrrfmenlq teiqemeflq
      181 fskglsfmrk edfaewllff tntenkdiyw knvreklsag esisldefks fchftthled
      241 faiamqmfsl ahrpvrlaef kravkvatgq elsnnildtv fkifdldgde clsheeflgv
      301 lknrmhrglw vpqhqsiqey wkcvkkesik gvkevwkqag kglf
//
LOCUS       XP_047286099             317 aa            linear   PRI 05-AUG-2025
DEFINITION  calcium uptake protein 2, mitochondrial isoform X3 [Homo sapiens].
ACCESSION   XP_047286099
VERSION     XP_047286099.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430143.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..317
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..317
                     /product="calcium uptake protein 2, mitochondrial isoform
                     X3"
                     /calculated_mol_wt=36038
     Region          176..>265
                     /region_name="EFh_MICU"
                     /note="EF-hand, calcium binding motif, found in
                     mitochondrial calcium uptake proteins MICU1, MICU2, MICU3,
                     and similar proteins; cl28896"
                     /db_xref="CDD:333716"
     Region          176..205
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320080"
     Region          233..263
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320080"
     CDS             1..317
                     /gene="MICU2"
                     /gene_synonym="1110008L20Rik; EFHA1; hMICU3"
                     /coded_by="XM_047430143.1:23..976"
                     /db_xref="GeneID:221154"
                     /db_xref="HGNC:HGNC:31830"
                     /db_xref="MIM:610632"
ORIGIN      
        1 maaaagscar vaawggklrr glavsrqavr spgplaaava gaalagagaa whhsrvsvaa
       61 rdgsftvsaq knvehgiiyi gkpslrkqrf mqfssleheg eyymtprdfl fsvmfeqmer
      121 ktsvkkltkk diedtlsgiq tagcgstffr dlgdkglisy teylflltil tkphsgfhva
      181 fkmldtdgne miekreffkl qkiiskqddl mtvktnetgy qeaivkepei nttlqmrffg
      241 krgqrklhyk efrrfmenlq teiqemeflq fskglsfmrk edfaewllff tntenkdiyw
      301 knvreklsag erslrel
//
LOCUS       XP_016875922             252 aa            linear   PRI 05-AUG-2025
DEFINITION  calcium uptake protein 2, mitochondrial isoform X4 [Homo sapiens].
ACCESSION   XP_016875922
VERSION     XP_016875922.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020433.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..252
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..252
                     /product="calcium uptake protein 2, mitochondrial isoform
                     X4"
                     /calculated_mol_wt=29821
     Region          1..213
                     /region_name="EFh_MICU"
                     /note="EF-hand, calcium binding motif, found in
                     mitochondrial calcium uptake proteins MICU1, MICU2, MICU3,
                     and similar proteins; cl28896"
                     /db_xref="CDD:333716"
     Site            order(3,5,7,14,193,195,197,204)
                     /site_type="other"
                     /note="Ca binding site [ion binding]"
                     /db_xref="CDD:320080"
     Region          51..81
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320080"
     Region          147..176
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320080"
     Region          184..213
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320080"
     CDS             1..252
                     /gene="MICU2"
                     /gene_synonym="1110008L20Rik; EFHA1; hMICU3"
                     /coded_by="XM_017020433.2:250..1008"
                     /db_xref="GeneID:221154"
                     /db_xref="HGNC:HGNC:31830"
                     /db_xref="MIM:610632"
ORIGIN      
        1 mldtdgnemi ekreffklqk iiskqddlmt vktnetgyqe aivkepeint tlqmrffgkr
       61 gqrklhykef rrfmenlqte iqemeflqfs kglsfmrked faewllfftn tenkdiywkn
      121 vreklsages isldefksfc hftthledfa iamqmfslah rpvrlaefkr avkvatgqel
      181 snnildtvfk ifdldgdecl sheeflgvlk nrmhrglwvp qhqsiqeywk cvkkesikgv
      241 kevwkqagkg lf
//
LOCUS       XP_047286101             690 aa            linear   PRI 05-AUG-2025
DEFINITION  ligand of Numb protein X 2 isoform X1 [Homo sapiens].
ACCESSION   XP_047286101
VERSION     XP_047286101.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430145.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..690
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..690
                     /product="ligand of Numb protein X 2 isoform X1"
                     /calculated_mol_wt=75873
     Region          45..89
                     /region_name="mRING-HC-C3HC3D_LNX2"
                     /note="Modified RING finger, HC subclass (C3HC3D-type),
                     found in ligand of numb protein X 2 (LNX2); cd16780"
                     /db_xref="CDD:319694"
     Site            order(45,47..48,57,65..68)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:319694"
     Region          229..317
                     /region_name="PDZ1_LNX1_2-like"
                     /note="PDZ domain 1 of human Ligand of Numb protein X 1
                     (LNX1) and LNX2, and related domains; cd06677"
                     /db_xref="CDD:467165"
     Site            order(244..250,263,266,296,300,303..304)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467165"
     Region          338..420
                     /region_name="PDZ2_LNX1_2-like"
                     /note="PDZ domain 2 of human Ligand of Numb protein X 1
                     (LNX1) and LNX2, and related domains; cd06678"
                     /db_xref="CDD:467166"
     Site            order(350..356,367,370,400,404,407..408)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467166"
     Region          467..554
                     /region_name="PDZ3_LNX1_2-like"
                     /note="PDZ domain 3 of human Ligand of Numb protein X 1
                     (LNX1) and LNX2, and related domains; cd06679"
                     /db_xref="CDD:467167"
     Site            order(478..484,499,502,532,536,539..540)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467167"
     Region          599..687
                     /region_name="PDZ4_LNX1_2-like"
                     /note="PDZ domain 4 of human Ligand of Numb protein X 1
                     (LNX1) and LNX2, and related domains; cd06680"
                     /db_xref="CDD:467168"
     Site            order(610..616,631,634,664,668,671..672)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467168"
     CDS             1..690
                     /gene="LNX2"
                     /gene_synonym="PDZRN1"
                     /coded_by="XM_047430145.1:613..2685"
                     /db_xref="GeneID:222484"
                     /db_xref="HGNC:HGNC:20421"
                     /db_xref="MIM:609733"
ORIGIN      
        1 mgttsdemvs veqtssssln plcfecgqqh wtrenhlyny qnevdddlvc hiclqpllqp
       61 ldtpcghtfc ykclrnflqe kdfcpldrkr lhfklckkss ilvhklldkl lvlcpfssvc
      121 kdvmqrcdle ahlknrcpga shrrvalerr ktsrtqaeie nengptlldp agtlspeadc
      181 lgtgavpver hltsaslstw seepgldnpa feesagadtt qqplslpege ittieihrsn
      241 pyiqlgisiv ggnetplini viqevyrdgv iardgrllag dqilqvnnyn isnvshnyar
      301 avlsqpcntl hltvlrerrf gnrahnhsds nspreeifqv alhkrdsgeq lgiklvrrtd
      361 epgvfildll egglaaqdgr lssndrvlai nghdlkygtp elaaqiiqas gervnltiar
      421 pgkpqpgnti reagnhssss qhhtpppyys rpsshkdltq cvtcqekhit vkkepheslg
      481 mtvaggrgsk sgelpifvts vpphgclard grikrgdvll ningidltnl shseavamlk
      541 asaaspaval kalevqivee atqnaeeqps tfseneydas wspswvmwlg lpstlhschd
      601 ivlrrsylgs wgfsivggye enhtnqpffi ktivlgtpay ydgrlkcgdm ivavnglstv
      661 gmshsalvpm lkeqrnkvtl tvicwpgslv
//
LOCUS       XP_016875923             690 aa            linear   PRI 05-AUG-2025
DEFINITION  ligand of Numb protein X 2 isoform X1 [Homo sapiens].
ACCESSION   XP_016875923
VERSION     XP_016875923.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020434.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..690
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..690
                     /product="ligand of Numb protein X 2 isoform X1"
                     /calculated_mol_wt=75873
     Region          45..89
                     /region_name="mRING-HC-C3HC3D_LNX2"
                     /note="Modified RING finger, HC subclass (C3HC3D-type),
                     found in ligand of numb protein X 2 (LNX2); cd16780"
                     /db_xref="CDD:319694"
     Site            order(45,47..48,57,65..68)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:319694"
     Region          229..317
                     /region_name="PDZ1_LNX1_2-like"
                     /note="PDZ domain 1 of human Ligand of Numb protein X 1
                     (LNX1) and LNX2, and related domains; cd06677"
                     /db_xref="CDD:467165"
     Site            order(244..250,263,266,296,300,303..304)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467165"
     Region          338..420
                     /region_name="PDZ2_LNX1_2-like"
                     /note="PDZ domain 2 of human Ligand of Numb protein X 1
                     (LNX1) and LNX2, and related domains; cd06678"
                     /db_xref="CDD:467166"
     Site            order(350..356,367,370,400,404,407..408)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467166"
     Region          467..554
                     /region_name="PDZ3_LNX1_2-like"
                     /note="PDZ domain 3 of human Ligand of Numb protein X 1
                     (LNX1) and LNX2, and related domains; cd06679"
                     /db_xref="CDD:467167"
     Site            order(478..484,499,502,532,536,539..540)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467167"
     Region          599..687
                     /region_name="PDZ4_LNX1_2-like"
                     /note="PDZ domain 4 of human Ligand of Numb protein X 1
                     (LNX1) and LNX2, and related domains; cd06680"
                     /db_xref="CDD:467168"
     Site            order(610..616,631,634,664,668,671..672)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467168"
     CDS             1..690
                     /gene="LNX2"
                     /gene_synonym="PDZRN1"
                     /coded_by="XM_017020434.2:170..2242"
                     /db_xref="GeneID:222484"
                     /db_xref="HGNC:HGNC:20421"
                     /db_xref="MIM:609733"
ORIGIN      
        1 mgttsdemvs veqtssssln plcfecgqqh wtrenhlyny qnevdddlvc hiclqpllqp
       61 ldtpcghtfc ykclrnflqe kdfcpldrkr lhfklckkss ilvhklldkl lvlcpfssvc
      121 kdvmqrcdle ahlknrcpga shrrvalerr ktsrtqaeie nengptlldp agtlspeadc
      181 lgtgavpver hltsaslstw seepgldnpa feesagadtt qqplslpege ittieihrsn
      241 pyiqlgisiv ggnetplini viqevyrdgv iardgrllag dqilqvnnyn isnvshnyar
      301 avlsqpcntl hltvlrerrf gnrahnhsds nspreeifqv alhkrdsgeq lgiklvrrtd
      361 epgvfildll egglaaqdgr lssndrvlai nghdlkygtp elaaqiiqas gervnltiar
      421 pgkpqpgnti reagnhssss qhhtpppyys rpsshkdltq cvtcqekhit vkkepheslg
      481 mtvaggrgsk sgelpifvts vpphgclard grikrgdvll ningidltnl shseavamlk
      541 asaaspaval kalevqivee atqnaeeqps tfseneydas wspswvmwlg lpstlhschd
      601 ivlrrsylgs wgfsivggye enhtnqpffi ktivlgtpay ydgrlkcgdm ivavnglstv
      661 gmshsalvpm lkeqrnkvtl tvicwpgslv
//
LOCUS       XP_047286103             690 aa            linear   PRI 05-AUG-2025
DEFINITION  ligand of Numb protein X 2 isoform X1 [Homo sapiens].
ACCESSION   XP_047286103
VERSION     XP_047286103.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430147.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..690
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..690
                     /product="ligand of Numb protein X 2 isoform X1"
                     /calculated_mol_wt=75873
     Region          45..89
                     /region_name="mRING-HC-C3HC3D_LNX2"
                     /note="Modified RING finger, HC subclass (C3HC3D-type),
                     found in ligand of numb protein X 2 (LNX2); cd16780"
                     /db_xref="CDD:319694"
     Site            order(45,47..48,57,65..68)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:319694"
     Region          229..317
                     /region_name="PDZ1_LNX1_2-like"
                     /note="PDZ domain 1 of human Ligand of Numb protein X 1
                     (LNX1) and LNX2, and related domains; cd06677"
                     /db_xref="CDD:467165"
     Site            order(244..250,263,266,296,300,303..304)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467165"
     Region          338..420
                     /region_name="PDZ2_LNX1_2-like"
                     /note="PDZ domain 2 of human Ligand of Numb protein X 1
                     (LNX1) and LNX2, and related domains; cd06678"
                     /db_xref="CDD:467166"
     Site            order(350..356,367,370,400,404,407..408)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467166"
     Region          467..554
                     /region_name="PDZ3_LNX1_2-like"
                     /note="PDZ domain 3 of human Ligand of Numb protein X 1
                     (LNX1) and LNX2, and related domains; cd06679"
                     /db_xref="CDD:467167"
     Site            order(478..484,499,502,532,536,539..540)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467167"
     Region          599..687
                     /region_name="PDZ4_LNX1_2-like"
                     /note="PDZ domain 4 of human Ligand of Numb protein X 1
                     (LNX1) and LNX2, and related domains; cd06680"
                     /db_xref="CDD:467168"
     Site            order(610..616,631,634,664,668,671..672)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467168"
     CDS             1..690
                     /gene="LNX2"
                     /gene_synonym="PDZRN1"
                     /coded_by="XM_047430147.1:12134..14206"
                     /db_xref="GeneID:222484"
                     /db_xref="HGNC:HGNC:20421"
                     /db_xref="MIM:609733"
ORIGIN      
        1 mgttsdemvs veqtssssln plcfecgqqh wtrenhlyny qnevdddlvc hiclqpllqp
       61 ldtpcghtfc ykclrnflqe kdfcpldrkr lhfklckkss ilvhklldkl lvlcpfssvc
      121 kdvmqrcdle ahlknrcpga shrrvalerr ktsrtqaeie nengptlldp agtlspeadc
      181 lgtgavpver hltsaslstw seepgldnpa feesagadtt qqplslpege ittieihrsn
      241 pyiqlgisiv ggnetplini viqevyrdgv iardgrllag dqilqvnnyn isnvshnyar
      301 avlsqpcntl hltvlrerrf gnrahnhsds nspreeifqv alhkrdsgeq lgiklvrrtd
      361 epgvfildll egglaaqdgr lssndrvlai nghdlkygtp elaaqiiqas gervnltiar
      421 pgkpqpgnti reagnhssss qhhtpppyys rpsshkdltq cvtcqekhit vkkepheslg
      481 mtvaggrgsk sgelpifvts vpphgclard grikrgdvll ningidltnl shseavamlk
      541 asaaspaval kalevqivee atqnaeeqps tfseneydas wspswvmwlg lpstlhschd
      601 ivlrrsylgs wgfsivggye enhtnqpffi ktivlgtpay ydgrlkcgdm ivavnglstv
      661 gmshsalvpm lkeqrnkvtl tvicwpgslv
//
LOCUS       XP_047286104             690 aa            linear   PRI 05-AUG-2025
DEFINITION  ligand of Numb protein X 2 isoform X1 [Homo sapiens].
ACCESSION   XP_047286104
VERSION     XP_047286104.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430148.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..690
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..690
                     /product="ligand of Numb protein X 2 isoform X1"
                     /calculated_mol_wt=75873
     Region          45..89
                     /region_name="mRING-HC-C3HC3D_LNX2"
                     /note="Modified RING finger, HC subclass (C3HC3D-type),
                     found in ligand of numb protein X 2 (LNX2); cd16780"
                     /db_xref="CDD:319694"
     Site            order(45,47..48,57,65..68)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:319694"
     Region          229..317
                     /region_name="PDZ1_LNX1_2-like"
                     /note="PDZ domain 1 of human Ligand of Numb protein X 1
                     (LNX1) and LNX2, and related domains; cd06677"
                     /db_xref="CDD:467165"
     Site            order(244..250,263,266,296,300,303..304)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467165"
     Region          338..420
                     /region_name="PDZ2_LNX1_2-like"
                     /note="PDZ domain 2 of human Ligand of Numb protein X 1
                     (LNX1) and LNX2, and related domains; cd06678"
                     /db_xref="CDD:467166"
     Site            order(350..356,367,370,400,404,407..408)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467166"
     Region          467..554
                     /region_name="PDZ3_LNX1_2-like"
                     /note="PDZ domain 3 of human Ligand of Numb protein X 1
                     (LNX1) and LNX2, and related domains; cd06679"
                     /db_xref="CDD:467167"
     Site            order(478..484,499,502,532,536,539..540)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467167"
     Region          599..687
                     /region_name="PDZ4_LNX1_2-like"
                     /note="PDZ domain 4 of human Ligand of Numb protein X 1
                     (LNX1) and LNX2, and related domains; cd06680"
                     /db_xref="CDD:467168"
     Site            order(610..616,631,634,664,668,671..672)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467168"
     CDS             1..690
                     /gene="LNX2"
                     /gene_synonym="PDZRN1"
                     /coded_by="XM_047430148.1:321..2393"
                     /db_xref="GeneID:222484"
                     /db_xref="HGNC:HGNC:20421"
                     /db_xref="MIM:609733"
ORIGIN      
        1 mgttsdemvs veqtssssln plcfecgqqh wtrenhlyny qnevdddlvc hiclqpllqp
       61 ldtpcghtfc ykclrnflqe kdfcpldrkr lhfklckkss ilvhklldkl lvlcpfssvc
      121 kdvmqrcdle ahlknrcpga shrrvalerr ktsrtqaeie nengptlldp agtlspeadc
      181 lgtgavpver hltsaslstw seepgldnpa feesagadtt qqplslpege ittieihrsn
      241 pyiqlgisiv ggnetplini viqevyrdgv iardgrllag dqilqvnnyn isnvshnyar
      301 avlsqpcntl hltvlrerrf gnrahnhsds nspreeifqv alhkrdsgeq lgiklvrrtd
      361 epgvfildll egglaaqdgr lssndrvlai nghdlkygtp elaaqiiqas gervnltiar
      421 pgkpqpgnti reagnhssss qhhtpppyys rpsshkdltq cvtcqekhit vkkepheslg
      481 mtvaggrgsk sgelpifvts vpphgclard grikrgdvll ningidltnl shseavamlk
      541 asaaspaval kalevqivee atqnaeeqps tfseneydas wspswvmwlg lpstlhschd
      601 ivlrrsylgs wgfsivggye enhtnqpffi ktivlgtpay ydgrlkcgdm ivavnglstv
      661 gmshsalvpm lkeqrnkvtl tvicwpgslv
//
LOCUS       XP_047286105             690 aa            linear   PRI 05-AUG-2025
DEFINITION  ligand of Numb protein X 2 isoform X1 [Homo sapiens].
ACCESSION   XP_047286105
VERSION     XP_047286105.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430149.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..690
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..690
                     /product="ligand of Numb protein X 2 isoform X1"
                     /calculated_mol_wt=75873
     Region          45..89
                     /region_name="mRING-HC-C3HC3D_LNX2"
                     /note="Modified RING finger, HC subclass (C3HC3D-type),
                     found in ligand of numb protein X 2 (LNX2); cd16780"
                     /db_xref="CDD:319694"
     Site            order(45,47..48,57,65..68)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:319694"
     Region          229..317
                     /region_name="PDZ1_LNX1_2-like"
                     /note="PDZ domain 1 of human Ligand of Numb protein X 1
                     (LNX1) and LNX2, and related domains; cd06677"
                     /db_xref="CDD:467165"
     Site            order(244..250,263,266,296,300,303..304)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467165"
     Region          338..420
                     /region_name="PDZ2_LNX1_2-like"
                     /note="PDZ domain 2 of human Ligand of Numb protein X 1
                     (LNX1) and LNX2, and related domains; cd06678"
                     /db_xref="CDD:467166"
     Site            order(350..356,367,370,400,404,407..408)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467166"
     Region          467..554
                     /region_name="PDZ3_LNX1_2-like"
                     /note="PDZ domain 3 of human Ligand of Numb protein X 1
                     (LNX1) and LNX2, and related domains; cd06679"
                     /db_xref="CDD:467167"
     Site            order(478..484,499,502,532,536,539..540)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467167"
     Region          599..687
                     /region_name="PDZ4_LNX1_2-like"
                     /note="PDZ domain 4 of human Ligand of Numb protein X 1
                     (LNX1) and LNX2, and related domains; cd06680"
                     /db_xref="CDD:467168"
     Site            order(610..616,631,634,664,668,671..672)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467168"
     CDS             1..690
                     /gene="LNX2"
                     /gene_synonym="PDZRN1"
                     /coded_by="XM_047430149.1:778..2850"
                     /db_xref="GeneID:222484"
                     /db_xref="HGNC:HGNC:20421"
                     /db_xref="MIM:609733"
ORIGIN      
        1 mgttsdemvs veqtssssln plcfecgqqh wtrenhlyny qnevdddlvc hiclqpllqp
       61 ldtpcghtfc ykclrnflqe kdfcpldrkr lhfklckkss ilvhklldkl lvlcpfssvc
      121 kdvmqrcdle ahlknrcpga shrrvalerr ktsrtqaeie nengptlldp agtlspeadc
      181 lgtgavpver hltsaslstw seepgldnpa feesagadtt qqplslpege ittieihrsn
      241 pyiqlgisiv ggnetplini viqevyrdgv iardgrllag dqilqvnnyn isnvshnyar
      301 avlsqpcntl hltvlrerrf gnrahnhsds nspreeifqv alhkrdsgeq lgiklvrrtd
      361 epgvfildll egglaaqdgr lssndrvlai nghdlkygtp elaaqiiqas gervnltiar
      421 pgkpqpgnti reagnhssss qhhtpppyys rpsshkdltq cvtcqekhit vkkepheslg
      481 mtvaggrgsk sgelpifvts vpphgclard grikrgdvll ningidltnl shseavamlk
      541 asaaspaval kalevqivee atqnaeeqps tfseneydas wspswvmwlg lpstlhschd
      601 ivlrrsylgs wgfsivggye enhtnqpffi ktivlgtpay ydgrlkcgdm ivavnglstv
      661 gmshsalvpm lkeqrnkvtl tvicwpgslv
//
LOCUS       XP_047286106             690 aa            linear   PRI 05-AUG-2025
DEFINITION  ligand of Numb protein X 2 isoform X1 [Homo sapiens].
ACCESSION   XP_047286106
VERSION     XP_047286106.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430150.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..690
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..690
                     /product="ligand of Numb protein X 2 isoform X1"
                     /calculated_mol_wt=75873
     Region          45..89
                     /region_name="mRING-HC-C3HC3D_LNX2"
                     /note="Modified RING finger, HC subclass (C3HC3D-type),
                     found in ligand of numb protein X 2 (LNX2); cd16780"
                     /db_xref="CDD:319694"
     Site            order(45,47..48,57,65..68)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:319694"
     Region          229..317
                     /region_name="PDZ1_LNX1_2-like"
                     /note="PDZ domain 1 of human Ligand of Numb protein X 1
                     (LNX1) and LNX2, and related domains; cd06677"
                     /db_xref="CDD:467165"
     Site            order(244..250,263,266,296,300,303..304)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467165"
     Region          338..420
                     /region_name="PDZ2_LNX1_2-like"
                     /note="PDZ domain 2 of human Ligand of Numb protein X 1
                     (LNX1) and LNX2, and related domains; cd06678"
                     /db_xref="CDD:467166"
     Site            order(350..356,367,370,400,404,407..408)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467166"
     Region          467..554
                     /region_name="PDZ3_LNX1_2-like"
                     /note="PDZ domain 3 of human Ligand of Numb protein X 1
                     (LNX1) and LNX2, and related domains; cd06679"
                     /db_xref="CDD:467167"
     Site            order(478..484,499,502,532,536,539..540)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467167"
     Region          599..687
                     /region_name="PDZ4_LNX1_2-like"
                     /note="PDZ domain 4 of human Ligand of Numb protein X 1
                     (LNX1) and LNX2, and related domains; cd06680"
                     /db_xref="CDD:467168"
     Site            order(610..616,631,634,664,668,671..672)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467168"
     CDS             1..690
                     /gene="LNX2"
                     /gene_synonym="PDZRN1"
                     /coded_by="XM_047430150.1:608..2680"
                     /db_xref="GeneID:222484"
                     /db_xref="HGNC:HGNC:20421"
                     /db_xref="MIM:609733"
ORIGIN      
        1 mgttsdemvs veqtssssln plcfecgqqh wtrenhlyny qnevdddlvc hiclqpllqp
       61 ldtpcghtfc ykclrnflqe kdfcpldrkr lhfklckkss ilvhklldkl lvlcpfssvc
      121 kdvmqrcdle ahlknrcpga shrrvalerr ktsrtqaeie nengptlldp agtlspeadc
      181 lgtgavpver hltsaslstw seepgldnpa feesagadtt qqplslpege ittieihrsn
      241 pyiqlgisiv ggnetplini viqevyrdgv iardgrllag dqilqvnnyn isnvshnyar
      301 avlsqpcntl hltvlrerrf gnrahnhsds nspreeifqv alhkrdsgeq lgiklvrrtd
      361 epgvfildll egglaaqdgr lssndrvlai nghdlkygtp elaaqiiqas gervnltiar
      421 pgkpqpgnti reagnhssss qhhtpppyys rpsshkdltq cvtcqekhit vkkepheslg
      481 mtvaggrgsk sgelpifvts vpphgclard grikrgdvll ningidltnl shseavamlk
      541 asaaspaval kalevqivee atqnaeeqps tfseneydas wspswvmwlg lpstlhschd
      601 ivlrrsylgs wgfsivggye enhtnqpffi ktivlgtpay ydgrlkcgdm ivavnglstv
      661 gmshsalvpm lkeqrnkvtl tvicwpgslv
//
LOCUS       XP_011533297             567 aa            linear   PRI 05-AUG-2025
DEFINITION  ligand of Numb protein X 2 isoform X2 [Homo sapiens].
ACCESSION   XP_011533297
VERSION     XP_011533297.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534995.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..567
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..567
                     /product="ligand of Numb protein X 2 isoform X2"
                     /calculated_mol_wt=62168
     Region          45..89
                     /region_name="mRING-HC-C3HC3D_LNX2"
                     /note="Modified RING finger, HC subclass (C3HC3D-type),
                     found in ligand of numb protein X 2 (LNX2); cd16780"
                     /db_xref="CDD:319694"
     Site            order(45,47..48,57,65..68)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:319694"
     Region          229..308
                     /region_name="PDZ_canonical"
                     /note="canonical PDZ domain; cl49608"
                     /db_xref="CDD:483948"
     Site            order(244..250,263,266,297,300..301)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467165"
     Region          344..431
                     /region_name="PDZ3_LNX1_2-like"
                     /note="PDZ domain 3 of human Ligand of Numb protein X 1
                     (LNX1) and LNX2, and related domains; cd06679"
                     /db_xref="CDD:467167"
     Site            order(355..361,376,379,409,413,416..417)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467167"
     Region          476..564
                     /region_name="PDZ4_LNX1_2-like"
                     /note="PDZ domain 4 of human Ligand of Numb protein X 1
                     (LNX1) and LNX2, and related domains; cd06680"
                     /db_xref="CDD:467168"
     Site            order(487..493,508,511,541,545,548..549)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467168"
     CDS             1..567
                     /gene="LNX2"
                     /gene_synonym="PDZRN1"
                     /coded_by="XM_011534995.3:256..1959"
                     /db_xref="GeneID:222484"
                     /db_xref="HGNC:HGNC:20421"
                     /db_xref="MIM:609733"
ORIGIN      
        1 mgttsdemvs veqtssssln plcfecgqqh wtrenhlyny qnevdddlvc hiclqpllqp
       61 ldtpcghtfc ykclrnflqe kdfcpldrkr lhfklckkss ilvhklldkl lvlcpfssvc
      121 kdvmqrcdle ahlknrcpga shrrvalerr ktsrtqaeie nengptlldp agtlspeadc
      181 lgtgavpver hltsaslstw seepgldnpa feesagadtt qqplslpege ittieihrsn
      241 pyiqlgisiv ggnetplini viqevyrdgv iardgrllag dqilqasger vnltiarpgk
      301 pqpgntirea gnhssssqhh tpppyysrps shkdltqcvt cqekhitvkk epheslgmtv
      361 aggrgsksge lpifvtsvpp hgclardgri krgdvllnin gidltnlshs eavamlkasa
      421 aspavalkal evqiveeatq naeeqpstfs eneydaswsp swvmwlglps tlhschdivl
      481 rrsylgswgf sivggyeenh tnqpffikti vlgtpayydg rlkcgdmiva vnglstvgms
      541 hsalvpmlke qrnkvtltvi cwpgslv
//
LOCUS       XP_047286107             567 aa            linear   PRI 05-AUG-2025
DEFINITION  ligand of Numb protein X 2 isoform X2 [Homo sapiens].
ACCESSION   XP_047286107
VERSION     XP_047286107.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430151.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..567
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..567
                     /product="ligand of Numb protein X 2 isoform X2"
                     /calculated_mol_wt=62168
     Region          45..89
                     /region_name="mRING-HC-C3HC3D_LNX2"
                     /note="Modified RING finger, HC subclass (C3HC3D-type),
                     found in ligand of numb protein X 2 (LNX2); cd16780"
                     /db_xref="CDD:319694"
     Site            order(45,47..48,57,65..68)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:319694"
     Region          229..308
                     /region_name="PDZ_canonical"
                     /note="canonical PDZ domain; cl49608"
                     /db_xref="CDD:483948"
     Site            order(244..250,263,266,297,300..301)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467165"
     Region          344..431
                     /region_name="PDZ3_LNX1_2-like"
                     /note="PDZ domain 3 of human Ligand of Numb protein X 1
                     (LNX1) and LNX2, and related domains; cd06679"
                     /db_xref="CDD:467167"
     Site            order(355..361,376,379,409,413,416..417)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467167"
     Region          476..564
                     /region_name="PDZ4_LNX1_2-like"
                     /note="PDZ domain 4 of human Ligand of Numb protein X 1
                     (LNX1) and LNX2, and related domains; cd06680"
                     /db_xref="CDD:467168"
     Site            order(487..493,508,511,541,545,548..549)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467168"
     CDS             1..567
                     /gene="LNX2"
                     /gene_synonym="PDZRN1"
                     /coded_by="XM_047430151.1:613..2316"
                     /db_xref="GeneID:222484"
                     /db_xref="HGNC:HGNC:20421"
                     /db_xref="MIM:609733"
ORIGIN      
        1 mgttsdemvs veqtssssln plcfecgqqh wtrenhlyny qnevdddlvc hiclqpllqp
       61 ldtpcghtfc ykclrnflqe kdfcpldrkr lhfklckkss ilvhklldkl lvlcpfssvc
      121 kdvmqrcdle ahlknrcpga shrrvalerr ktsrtqaeie nengptlldp agtlspeadc
      181 lgtgavpver hltsaslstw seepgldnpa feesagadtt qqplslpege ittieihrsn
      241 pyiqlgisiv ggnetplini viqevyrdgv iardgrllag dqilqasger vnltiarpgk
      301 pqpgntirea gnhssssqhh tpppyysrps shkdltqcvt cqekhitvkk epheslgmtv
      361 aggrgsksge lpifvtsvpp hgclardgri krgdvllnin gidltnlshs eavamlkasa
      421 aspavalkal evqiveeatq naeeqpstfs eneydaswsp swvmwlglps tlhschdivl
      481 rrsylgswgf sivggyeenh tnqpffikti vlgtpayydg rlkcgdmiva vnglstvgms
      541 hsalvpmlke qrnkvtltvi cwpgslv
//
LOCUS       XP_011533298             158 aa            linear   PRI 05-AUG-2025
DEFINITION  fibroblast growth factor 9 isoform X1 [Homo sapiens].
ACCESSION   XP_011533298
VERSION     XP_011533298.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534996.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..158
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..158
                     /product="fibroblast growth factor 9 isoform X1"
                     /calculated_mol_wt=17934
     Region          <37..155
                     /region_name="beta-trefoil_FGF"
                     /note="FGF domain, beta-trefoil fold, found in acidic and
                     basic fibroblast growth factor (FGF) superfamily; cl00060"
                     /db_xref="CDD:469595"
     CDS             1..158
                     /gene="FGF9"
                     /gene_synonym="FGF-9; GAF; HBFG-9; HBGF-9; SYNS3"
                     /coded_by="XM_011534996.3:310..786"
                     /db_xref="GeneID:2254"
                     /db_xref="HGNC:HGNC:3687"
                     /db_xref="MIM:600921"
ORIGIN      
        1 mrtaagysgs ietvkqkarp ltprgqrkvl sgkwhlhsld algilefisi avglvsirgv
       61 dsglylgmne kgelygsekl tqecvfreqf eenwyntyss nlykhvdtgr ryyvalnkdg
      121 tpregtrtkr hqkfthflpr pvdpdkvpel ykdilsqs
//
LOCUS       XP_016875924             565 aa            linear   PRI 05-AUG-2025
DEFINITION  glypican-5 isoform X1 [Homo sapiens].
ACCESSION   XP_016875924
VERSION     XP_016875924.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020435.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..565
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..565
                     /product="glypican-5 isoform X1"
                     /calculated_mol_wt=62907
     Region          12..521
                     /region_name="Glypican"
                     /note="pfam01153"
                     /db_xref="CDD:460084"
     CDS             1..565
                     /gene="GPC5"
                     /coded_by="XM_017020435.3:427..2124"
                     /db_xref="GeneID:2262"
                     /db_xref="HGNC:HGNC:4453"
                     /db_xref="MIM:602446"
ORIGIN      
        1 mdaqtwpvgf rcllllalvg sarsegvqtc eevrklfqwr llgavrglpd spragpdlqv
       61 ciskkptcct rkmeeryqia arqdmqqflq tssstlkfli srnaaafqet letlikqaen
      121 ytsilfcsty rnmaleaaas vqefftdvgl ylfgadvnpe efvnrffdsl fplvynhlin
      181 pgvtdssley secirmarrd vspfgnipqr vmgqmgrsll psrtflqaln lgievinttd
      241 ylhfskecsr allkmqycph cqglaltkpc mgyclnvmrg clahmaelnp hwhayirsle
      301 elsdamhgty dighvllnfh llvndavlqa hlngqklleq vnricgrpvr tptqsprcsf
      361 dqskekhgmk tttrnseetl anrrkefins lrlyrsfygg ladqlcanel aaadglpcwn
      421 gedivksytq rvvgngikaq sgnpevkvkg idpvinqiid klkhvvqllq grspkpdkwe
      481 llqlgsgggm veqvsgdcdd edgcggsgsg evkrtlkitd srgwftelcs litatsnevg
      541 lnifpvlptd rkgrlnkntp ngafe
//
LOCUS       XP_011519356             480 aa            linear   PRI 05-AUG-2025
DEFINITION  glypican-5 isoform X2 [Homo sapiens].
ACCESSION   XP_011519356
VERSION     XP_011519356.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521054.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..480
                     /product="glypican-5 isoform X2"
                     /calculated_mol_wt=54055
     Region          12..467
                     /region_name="Glypican"
                     /note="pfam01153"
                     /db_xref="CDD:460084"
     CDS             1..480
                     /gene="GPC5"
                     /coded_by="XM_011521054.4:427..1869"
                     /db_xref="GeneID:2262"
                     /db_xref="HGNC:HGNC:4453"
                     /db_xref="MIM:602446"
ORIGIN      
        1 mdaqtwpvgf rcllllalvg sarsegvqtc eevrklfqwr llgavrglpd spragpdlqv
       61 ciskkptcct rkmeeryqia arqdmqqflq tssstlkfli srnaaafqet letlikqaen
      121 ytsilfcsty rnmaleaaas vqefftdvgl ylfgadvnpe efvnrffdsl fplvynhlin
      181 pgvtdssley secirmarrd vspfgnipqr vmgqmgrsll psrtflqaln lgievinttd
      241 ylhfskecsr allkmqycph cqglaltkpc mgyclnvmrg clahmaelnp hwhayirsle
      301 elsdamhgty dighvllnfh llvndavlqa hlngqklleq vnricgrpvr tptqsprcsf
      361 dqskekhgmk tttrnseetl anrrkefins lrlyrsfygg ladqlcanel aaadglpcwn
      421 gedivksytq rvvgngikaq sgnpevkvkg idpvinqiid klkhvvqetn wklfgmnhli
//
LOCUS       XP_016875925             444 aa            linear   PRI 05-AUG-2025
DEFINITION  glypican-5 isoform X3 [Homo sapiens].
ACCESSION   XP_016875925
VERSION     XP_016875925.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020436.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..444
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..444
                     /product="glypican-5 isoform X3"
                     /calculated_mol_wt=50078
     Region          12..>423
                     /region_name="Glypican"
                     /note="pfam01153"
                     /db_xref="CDD:460084"
     CDS             1..444
                     /gene="GPC5"
                     /coded_by="XM_017020436.3:427..1761"
                     /db_xref="GeneID:2262"
                     /db_xref="HGNC:HGNC:4453"
                     /db_xref="MIM:602446"
ORIGIN      
        1 mdaqtwpvgf rcllllalvg sarsegvqtc eevrklfqwr llgavrglpd spragpdlqv
       61 ciskkptcct rkmeeryqia arqdmqqflq tssstlkfli srnaaafqet letlikqaen
      121 ytsilfcsty rnmaleaaas vqefftdvgl ylfgadvnpe efvnrffdsl fplvynhlin
      181 pgvtdssley secirmarrd vspfgnipqr vmgqmgrsll psrtflqaln lgievinttd
      241 ylhfskecsr allkmqycph cqglaltkpc mgyclnvmrg clahmaelnp hwhayirsle
      301 elsdamhgty dighvllnfh llvndavlqa hlngqklleq vnricgrpvr tptqsprcsf
      361 dqskekhgmk tttrnseetl anrrkefins lrlyrsfygg ladqlcanel aaadglpcwn
      421 gedivkswqv sswgddgskv rkkk
//
LOCUS       XP_011519357             444 aa            linear   PRI 05-AUG-2025
DEFINITION  glypican-5 isoform X3 [Homo sapiens].
ACCESSION   XP_011519357
VERSION     XP_011519357.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521055.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..444
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..444
                     /product="glypican-5 isoform X3"
                     /calculated_mol_wt=50078
     Region          12..>423
                     /region_name="Glypican"
                     /note="pfam01153"
                     /db_xref="CDD:460084"
     CDS             1..444
                     /gene="GPC5"
                     /coded_by="XM_011521055.4:427..1761"
                     /db_xref="GeneID:2262"
                     /db_xref="HGNC:HGNC:4453"
                     /db_xref="MIM:602446"
ORIGIN      
        1 mdaqtwpvgf rcllllalvg sarsegvqtc eevrklfqwr llgavrglpd spragpdlqv
       61 ciskkptcct rkmeeryqia arqdmqqflq tssstlkfli srnaaafqet letlikqaen
      121 ytsilfcsty rnmaleaaas vqefftdvgl ylfgadvnpe efvnrffdsl fplvynhlin
      181 pgvtdssley secirmarrd vspfgnipqr vmgqmgrsll psrtflqaln lgievinttd
      241 ylhfskecsr allkmqycph cqglaltkpc mgyclnvmrg clahmaelnp hwhayirsle
      301 elsdamhgty dighvllnfh llvndavlqa hlngqklleq vnricgrpvr tptqsprcsf
      361 dqskekhgmk tttrnseetl anrrkefins lrlyrsfygg ladqlcanel aaadglpcwn
      421 gedivkswqv sswgddgskv rkkk
//
LOCUS       XP_011519358             444 aa            linear   PRI 05-AUG-2025
DEFINITION  glypican-5 isoform X3 [Homo sapiens].
ACCESSION   XP_011519358
VERSION     XP_011519358.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521056.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..444
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..444
                     /product="glypican-5 isoform X3"
                     /calculated_mol_wt=50078
     Region          12..>423
                     /region_name="Glypican"
                     /note="pfam01153"
                     /db_xref="CDD:460084"
     CDS             1..444
                     /gene="GPC5"
                     /coded_by="XM_011521056.4:427..1761"
                     /db_xref="GeneID:2262"
                     /db_xref="HGNC:HGNC:4453"
                     /db_xref="MIM:602446"
ORIGIN      
        1 mdaqtwpvgf rcllllalvg sarsegvqtc eevrklfqwr llgavrglpd spragpdlqv
       61 ciskkptcct rkmeeryqia arqdmqqflq tssstlkfli srnaaafqet letlikqaen
      121 ytsilfcsty rnmaleaaas vqefftdvgl ylfgadvnpe efvnrffdsl fplvynhlin
      181 pgvtdssley secirmarrd vspfgnipqr vmgqmgrsll psrtflqaln lgievinttd
      241 ylhfskecsr allkmqycph cqglaltkpc mgyclnvmrg clahmaelnp hwhayirsle
      301 elsdamhgty dighvllnfh llvndavlqa hlngqklleq vnricgrpvr tptqsprcsf
      361 dqskekhgmk tttrnseetl anrrkefins lrlyrsfygg ladqlcanel aaadglpcwn
      421 gedivkswqv sswgddgskv rkkk
//
LOCUS       XP_011519359             444 aa            linear   PRI 05-AUG-2025
DEFINITION  glypican-5 isoform X3 [Homo sapiens].
ACCESSION   XP_011519359
VERSION     XP_011519359.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521057.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..444
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..444
                     /product="glypican-5 isoform X3"
                     /calculated_mol_wt=50078
     Region          12..>423
                     /region_name="Glypican"
                     /note="pfam01153"
                     /db_xref="CDD:460084"
     CDS             1..444
                     /gene="GPC5"
                     /coded_by="XM_011521057.4:427..1761"
                     /db_xref="GeneID:2262"
                     /db_xref="HGNC:HGNC:4453"
                     /db_xref="MIM:602446"
ORIGIN      
        1 mdaqtwpvgf rcllllalvg sarsegvqtc eevrklfqwr llgavrglpd spragpdlqv
       61 ciskkptcct rkmeeryqia arqdmqqflq tssstlkfli srnaaafqet letlikqaen
      121 ytsilfcsty rnmaleaaas vqefftdvgl ylfgadvnpe efvnrffdsl fplvynhlin
      181 pgvtdssley secirmarrd vspfgnipqr vmgqmgrsll psrtflqaln lgievinttd
      241 ylhfskecsr allkmqycph cqglaltkpc mgyclnvmrg clahmaelnp hwhayirsle
      301 elsdamhgty dighvllnfh llvndavlqa hlngqklleq vnricgrpvr tptqsprcsf
      361 dqskekhgmk tttrnseetl anrrkefins lrlyrsfygg ladqlcanel aaadglpcwn
      421 gedivkswqv sswgddgskv rkkk
//
LOCUS       XP_011519360             444 aa            linear   PRI 05-AUG-2025
DEFINITION  glypican-5 isoform X3 [Homo sapiens].
ACCESSION   XP_011519360
VERSION     XP_011519360.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521058.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..444
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..444
                     /product="glypican-5 isoform X3"
                     /calculated_mol_wt=50078
     Region          12..>423
                     /region_name="Glypican"
                     /note="pfam01153"
                     /db_xref="CDD:460084"
     CDS             1..444
                     /gene="GPC5"
                     /coded_by="XM_011521058.3:427..1761"
                     /db_xref="GeneID:2262"
                     /db_xref="HGNC:HGNC:4453"
                     /db_xref="MIM:602446"
ORIGIN      
        1 mdaqtwpvgf rcllllalvg sarsegvqtc eevrklfqwr llgavrglpd spragpdlqv
       61 ciskkptcct rkmeeryqia arqdmqqflq tssstlkfli srnaaafqet letlikqaen
      121 ytsilfcsty rnmaleaaas vqefftdvgl ylfgadvnpe efvnrffdsl fplvynhlin
      181 pgvtdssley secirmarrd vspfgnipqr vmgqmgrsll psrtflqaln lgievinttd
      241 ylhfskecsr allkmqycph cqglaltkpc mgyclnvmrg clahmaelnp hwhayirsle
      301 elsdamhgty dighvllnfh llvndavlqa hlngqklleq vnricgrpvr tptqsprcsf
      361 dqskekhgmk tttrnseetl anrrkefins lrlyrsfygg ladqlcanel aaadglpcwn
      421 gedivkswqv sswgddgskv rkkk
//
LOCUS       XP_016875926             444 aa            linear   PRI 05-AUG-2025
DEFINITION  glypican-5 isoform X3 [Homo sapiens].
ACCESSION   XP_016875926
VERSION     XP_016875926.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020437.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..444
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..444
                     /product="glypican-5 isoform X3"
                     /calculated_mol_wt=50078
     Region          12..>423
                     /region_name="Glypican"
                     /note="pfam01153"
                     /db_xref="CDD:460084"
     CDS             1..444
                     /gene="GPC5"
                     /coded_by="XM_017020437.2:427..1761"
                     /db_xref="GeneID:2262"
                     /db_xref="HGNC:HGNC:4453"
                     /db_xref="MIM:602446"
ORIGIN      
        1 mdaqtwpvgf rcllllalvg sarsegvqtc eevrklfqwr llgavrglpd spragpdlqv
       61 ciskkptcct rkmeeryqia arqdmqqflq tssstlkfli srnaaafqet letlikqaen
      121 ytsilfcsty rnmaleaaas vqefftdvgl ylfgadvnpe efvnrffdsl fplvynhlin
      181 pgvtdssley secirmarrd vspfgnipqr vmgqmgrsll psrtflqaln lgievinttd
      241 ylhfskecsr allkmqycph cqglaltkpc mgyclnvmrg clahmaelnp hwhayirsle
      301 elsdamhgty dighvllnfh llvndavlqa hlngqklleq vnricgrpvr tptqsprcsf
      361 dqskekhgmk tttrnseetl anrrkefins lrlyrsfygg ladqlcanel aaadglpcwn
      421 gedivkswqv sswgddgskv rkkk
//
LOCUS       XP_011519361             444 aa            linear   PRI 05-AUG-2025
DEFINITION  glypican-5 isoform X3 [Homo sapiens].
ACCESSION   XP_011519361
VERSION     XP_011519361.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521059.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..444
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..444
                     /product="glypican-5 isoform X3"
                     /calculated_mol_wt=50078
     Region          12..>423
                     /region_name="Glypican"
                     /note="pfam01153"
                     /db_xref="CDD:460084"
     CDS             1..444
                     /gene="GPC5"
                     /coded_by="XM_011521059.3:427..1761"
                     /db_xref="GeneID:2262"
                     /db_xref="HGNC:HGNC:4453"
                     /db_xref="MIM:602446"
ORIGIN      
        1 mdaqtwpvgf rcllllalvg sarsegvqtc eevrklfqwr llgavrglpd spragpdlqv
       61 ciskkptcct rkmeeryqia arqdmqqflq tssstlkfli srnaaafqet letlikqaen
      121 ytsilfcsty rnmaleaaas vqefftdvgl ylfgadvnpe efvnrffdsl fplvynhlin
      181 pgvtdssley secirmarrd vspfgnipqr vmgqmgrsll psrtflqaln lgievinttd
      241 ylhfskecsr allkmqycph cqglaltkpc mgyclnvmrg clahmaelnp hwhayirsle
      301 elsdamhgty dighvllnfh llvndavlqa hlngqklleq vnricgrpvr tptqsprcsf
      361 dqskekhgmk tttrnseetl anrrkefins lrlyrsfygg ladqlcanel aaadglpcwn
      421 gedivkswqv sswgddgskv rkkk
//
LOCUS       XP_011519362             443 aa            linear   PRI 05-AUG-2025
DEFINITION  glypican-5 isoform X4 [Homo sapiens].
ACCESSION   XP_011519362
VERSION     XP_011519362.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521060.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..443
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..443
                     /product="glypican-5 isoform X4"
                     /calculated_mol_wt=50169
     Region          12..>423
                     /region_name="Glypican"
                     /note="pfam01153"
                     /db_xref="CDD:460084"
     CDS             1..443
                     /gene="GPC5"
                     /coded_by="XM_011521060.3:427..1758"
                     /db_xref="GeneID:2262"
                     /db_xref="HGNC:HGNC:4453"
                     /db_xref="MIM:602446"
ORIGIN      
        1 mdaqtwpvgf rcllllalvg sarsegvqtc eevrklfqwr llgavrglpd spragpdlqv
       61 ciskkptcct rkmeeryqia arqdmqqflq tssstlkfli srnaaafqet letlikqaen
      121 ytsilfcsty rnmaleaaas vqefftdvgl ylfgadvnpe efvnrffdsl fplvynhlin
      181 pgvtdssley secirmarrd vspfgnipqr vmgqmgrsll psrtflqaln lgievinttd
      241 ylhfskecsr allkmqycph cqglaltkpc mgyclnvmrg clahmaelnp hwhayirsle
      301 elsdamhgty dighvllnfh llvndavlqa hlngqklleq vnricgrpvr tptqsprcsf
      361 dqskekhgmk tttrnseetl anrrkefins lrlyrsfygg ladqlcanel aaadglpcwn
      421 gedivkrcei winrllmtnh kle
//
LOCUS       XP_047286109             385 aa            linear   PRI 05-AUG-2025
DEFINITION  glypican-5 isoform X5 [Homo sapiens].
ACCESSION   XP_047286109
VERSION     XP_047286109.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430153.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..385
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..385
                     /product="glypican-5 isoform X5"
                     /calculated_mol_wt=43501
     Region          12..>385
                     /region_name="Glypican"
                     /note="pfam01153"
                     /db_xref="CDD:460084"
     CDS             1..385
                     /gene="GPC5"
                     /coded_by="XM_047430153.1:427..1584"
                     /db_xref="GeneID:2262"
                     /db_xref="HGNC:HGNC:4453"
                     /db_xref="MIM:602446"
ORIGIN      
        1 mdaqtwpvgf rcllllalvg sarsegvqtc eevrklfqwr llgavrglpd spragpdlqv
       61 ciskkptcct rkmeeryqia arqdmqqflq tssstlkfli srnaaafqet letlikqaen
      121 ytsilfcsty rnmaleaaas vqefftdvgl ylfgadvnpe efvnrffdsl fplvynhlin
      181 pgvtdssley secirmarrd vspfgnipqr vmgqmgrsll psrtflqaln lgievinttd
      241 ylhfskecsr allkmqycph cqglaltkpc mgyclnvmrg clahmaelnp hwhayirsle
      301 elsdamhgty dighvllnfh llvndavlqa hlngqklleq vnricgrpvr tptqsprcsf
      361 dqskekhgmk tttrnseetl anrrk
//
LOCUS       XP_047286110             878 aa            linear   PRI 05-AUG-2025
DEFINITION  ras GTPase-activating protein 3 isoform X1 [Homo sapiens].
ACCESSION   XP_047286110
VERSION     XP_047286110.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430154.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..878
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..878
                     /product="ras GTPase-activating protein 3 isoform X1"
                     /calculated_mol_wt=99935
     Region          <99..177
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     Region          190..332
                     /region_name="C2B_RasA3"
                     /note="C2 domain second repeat present in RAS p21 protein
                     activator 3 (RasA3); cd04010"
                     /db_xref="CDD:175977"
     Site            order(197,209,262,264,285,287)
                     /site_type="other"
                     /note="putative Ca2+ binding pocket [ion binding]"
                     /db_xref="CDD:175977"
     Region          341..609
                     /region_name="RasGAP_RASA3"
                     /note="Ras-GTPase Activating Domain of RASA3; cd05134"
                     /db_xref="CDD:213336"
     Site            order(375,411,413,415..416,418,421,425,520,528..529,
                     532..533,536,557,560..561,564,568,570,578..579)
                     /site_type="other"
                     /note="putative RAS interface [polypeptide binding]"
                     /db_xref="CDD:213336"
     Region          606..730
                     /region_name="PH_GAP1_mammal-like"
                     /note="GAP1(IP4BP) pleckstrin homology (PH) domain;
                     cd13371"
                     /db_xref="CDD:241522"
     Region          723..758
                     /region_name="BTK"
                     /note="Bruton's tyrosine kinase Cys-rich motif;
                     smart00107"
                     /db_xref="CDD:128417"
     CDS             1..878
                     /gene="RASA3"
                     /gene_synonym="GAP1IP4BP; GAPIII"
                     /coded_by="XM_047430154.1:26..2662"
                     /db_xref="GeneID:22821"
                     /db_xref="HGNC:HGNC:20331"
                     /db_xref="MIM:605182"
ORIGIN      
        1 mfscsflfll flslfiewis glfmnfkhln fhgqlsappe asrdpprcpa stglpppspp
       61 lpsrvterga tcaeplaeql ntplpgsaqg rrtlspaaqa lgpfygedfy ceiprsfrhl
      121 sfyifdrdvf rrdsiigkva iqkedlqkyh nrdtwfqlqh vdadsevqgk vhlelrlsev
      181 itdtgvvchk latrivecqg lpivngqcdp yatvtlagpf rseakktkvk rktnnpqfde
      241 vfyfevtrpc syskkshfdf eeedvdklei rvdlwnasnl kfgdeflgel riplkvlrqs
      301 ssyeawyflq prdngskslk pddlgslrln vvytedhvfs sdyysplrdl llksadvepv
      361 sasaahilge vcrekqeaav plvrlflhyg rvvpfisaia saevkrtqdp ntifrgnsla
      421 skcidetmkl agmhylhvtl kpaieeicqs hkpceidpvk lkdgenlenn menlrqyvdr
      481 vfhaitesgv scptvmcdif fslreaaakr fqddpdvryt avssfiflrf fapailspnl
      541 fqltphhtdp qtsrtltlis ktvqtlgsls ksksasfkes ymatfyeffn eqkyadavkn
      601 fldlisssgr rdpksveqpi vlkegfmikr aqgrkrfgmk nfkkrwfrlt nheftyhksk
      661 gdqplysipi enilavekle eesfkmknmf qviqperaly iqanncveak dwidiltkvs
      721 qcnqkrltvy hpsaylsghw lccrapsdsa pgcspctggl paniqldidg dreteriysl
      781 fnlymsklek mqeacgsksv ydgpeqeeys tfviddpqet yktlkqviag vgaleqehaq
      841 ykrdkfkktk ygsqehpigd ksfqnyirqq setsthsi
//
LOCUS       XP_011533143             802 aa            linear   PRI 05-AUG-2025
DEFINITION  ras GTPase-activating protein 3 isoform X2 [Homo sapiens].
ACCESSION   XP_011533143
VERSION     XP_011533143.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534841.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..802
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..802
                     /product="ras GTPase-activating protein 3 isoform X2"
                     /calculated_mol_wt=92097
     Region          1..101
                     /region_name="C2A_RasA2_RasA3"
                     /note="C2 domain first repeat present in RasA2 and RasA3;
                     cd08401"
                     /db_xref="CDD:176046"
     Site            order(3,50,52,57)
                     /site_type="other"
                     /note="putative Ca2+ binding site [ion binding]"
                     /db_xref="CDD:176046"
     Region          114..256
                     /region_name="C2B_RasA3"
                     /note="C2 domain second repeat present in RAS p21 protein
                     activator 3 (RasA3); cd04010"
                     /db_xref="CDD:175977"
     Site            order(121,133,186,188,209,211)
                     /site_type="other"
                     /note="putative Ca2+ binding pocket [ion binding]"
                     /db_xref="CDD:175977"
     Region          265..533
                     /region_name="RasGAP_RASA3"
                     /note="Ras-GTPase Activating Domain of RASA3; cd05134"
                     /db_xref="CDD:213336"
     Site            order(299,335,337,339..340,342,345,349,444,452..453,
                     456..457,460,481,484..485,488,492,494,502..503)
                     /site_type="other"
                     /note="putative RAS interface [polypeptide binding]"
                     /db_xref="CDD:213336"
     Region          530..654
                     /region_name="PH_GAP1_mammal-like"
                     /note="GAP1(IP4BP) pleckstrin homology (PH) domain;
                     cd13371"
                     /db_xref="CDD:241522"
     Region          647..682
                     /region_name="BTK"
                     /note="Bruton's tyrosine kinase Cys-rich motif;
                     smart00107"
                     /db_xref="CDD:128417"
     CDS             1..802
                     /gene="RASA3"
                     /gene_synonym="GAP1IP4BP; GAPIII"
                     /coded_by="XM_011534841.4:287..2695"
                     /db_xref="GeneID:22821"
                     /db_xref="HGNC:HGNC:20331"
                     /db_xref="MIM:605182"
ORIGIN      
        1 mrdcyctvnl dqeevfrtki vekslcpfyg edfyceiprs frhlsfyifd rdvfrrdsii
       61 gkvaiqkedl qkyhnrdtwf qlqhvdadse vqgkvhlelr lsevitdtgv vchklatriv
      121 ecqglpivng qcdpyatvtl agpfrseakk tkvkrktnnp qfdevfyfev trpcsyskks
      181 hfdfeeedvd kleirvdlwn asnlkfgdef lgelriplkv lrqsssyeaw yflqprdngs
      241 kslkpddlgs lrlnvvyted hvfssdyysp lrdlllksad vepvsasaah ilgevcrekq
      301 eaavplvrlf lhygrvvpfi saiasaevkr tqdpntifrg nslaskcide tmklagmhyl
      361 hvtlkpaiee icqshkpcei dpvklkdgen lennmenlrq yvdrvfhait esgvscptvm
      421 cdiffslrea aakrfqddpd vrytavssfi flrffapail spnlfqltph htdpqtsrtl
      481 tlisktvqtl gslsksksas fkesymatfy effneqkyad avknfldlis ssgrrdpksv
      541 eqpivlkegf mikraqgrkr fgmknfkkrw frltnhefty hkskgdqply sipienilav
      601 ekleeesfkm knmfqviqpe ralyiqannc veakdwidil tkvsqcnqkr ltvyhpsayl
      661 sghwlccrap sdsapgcspc tgglpaniql didgdreter iyslfnlyms klekmqeacg
      721 sksvydgpeq eeystfvidd pqetyktlkq viagvgaleq ehaqykrdkf kktkygsqeh
      781 pigdksfqny irqqsetsth si
//
LOCUS       XP_047286111             802 aa            linear   PRI 05-AUG-2025
DEFINITION  ras GTPase-activating protein 3 isoform X2 [Homo sapiens].
ACCESSION   XP_047286111
VERSION     XP_047286111.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430155.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 4% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..802
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..802
                     /product="ras GTPase-activating protein 3 isoform X2"
                     /calculated_mol_wt=92097
     Region          1..101
                     /region_name="C2A_RasA2_RasA3"
                     /note="C2 domain first repeat present in RasA2 and RasA3;
                     cd08401"
                     /db_xref="CDD:176046"
     Site            order(3,50,52,57)
                     /site_type="other"
                     /note="putative Ca2+ binding site [ion binding]"
                     /db_xref="CDD:176046"
     Region          114..256
                     /region_name="C2B_RasA3"
                     /note="C2 domain second repeat present in RAS p21 protein
                     activator 3 (RasA3); cd04010"
                     /db_xref="CDD:175977"
     Site            order(121,133,186,188,209,211)
                     /site_type="other"
                     /note="putative Ca2+ binding pocket [ion binding]"
                     /db_xref="CDD:175977"
     Region          265..533
                     /region_name="RasGAP_RASA3"
                     /note="Ras-GTPase Activating Domain of RASA3; cd05134"
                     /db_xref="CDD:213336"
     Site            order(299,335,337,339..340,342,345,349,444,452..453,
                     456..457,460,481,484..485,488,492,494,502..503)
                     /site_type="other"
                     /note="putative RAS interface [polypeptide binding]"
                     /db_xref="CDD:213336"
     Region          530..654
                     /region_name="PH_GAP1_mammal-like"
                     /note="GAP1(IP4BP) pleckstrin homology (PH) domain;
                     cd13371"
                     /db_xref="CDD:241522"
     Region          647..682
                     /region_name="BTK"
                     /note="Bruton's tyrosine kinase Cys-rich motif;
                     smart00107"
                     /db_xref="CDD:128417"
     CDS             1..802
                     /gene="RASA3"
                     /gene_synonym="GAP1IP4BP; GAPIII"
                     /coded_by="XM_047430155.1:600..3008"
                     /db_xref="GeneID:22821"
                     /db_xref="HGNC:HGNC:20331"
                     /db_xref="MIM:605182"
ORIGIN      
        1 mrdcyctvnl dqeevfrtki vekslcpfyg edfyceiprs frhlsfyifd rdvfrrdsii
       61 gkvaiqkedl qkyhnrdtwf qlqhvdadse vqgkvhlelr lsevitdtgv vchklatriv
      121 ecqglpivng qcdpyatvtl agpfrseakk tkvkrktnnp qfdevfyfev trpcsyskks
      181 hfdfeeedvd kleirvdlwn asnlkfgdef lgelriplkv lrqsssyeaw yflqprdngs
      241 kslkpddlgs lrlnvvyted hvfssdyysp lrdlllksad vepvsasaah ilgevcrekq
      301 eaavplvrlf lhygrvvpfi saiasaevkr tqdpntifrg nslaskcide tmklagmhyl
      361 hvtlkpaiee icqshkpcei dpvklkdgen lennmenlrq yvdrvfhait esgvscptvm
      421 cdiffslrea aakrfqddpd vrytavssfi flrffapail spnlfqltph htdpqtsrtl
      481 tlisktvqtl gslsksksas fkesymatfy effneqkyad avknfldlis ssgrrdpksv
      541 eqpivlkegf mikraqgrkr fgmknfkkrw frltnhefty hkskgdqply sipienilav
      601 ekleeesfkm knmfqviqpe ralyiqannc veakdwidil tkvsqcnqkr ltvyhpsayl
      661 sghwlccrap sdsapgcspc tgglpaniql didgdreter iyslfnlyms klekmqeacg
      721 sksvydgpeq eeystfvidd pqetyktlkq viagvgaleq ehaqykrdkf kktkygsqeh
      781 pigdksfqny irqqsetsth si
//
LOCUS       XP_047286112             878 aa            linear   PRI 05-AUG-2025
DEFINITION  ras GTPase-activating protein 3 isoform X3 [Homo sapiens].
ACCESSION   XP_047286112
VERSION     XP_047286112.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430156.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..878
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..878
                     /product="ras GTPase-activating protein 3 isoform X3"
                     /calculated_mol_wt=100498
     Region          63..177
                     /region_name="C2A_RasA2_RasA3"
                     /note="C2 domain first repeat present in RasA2 and RasA3;
                     cd08401"
                     /db_xref="CDD:176046"
     Site            order(79,126,128,133)
                     /site_type="other"
                     /note="putative Ca2+ binding site [ion binding]"
                     /db_xref="CDD:176046"
     Region          190..332
                     /region_name="C2B_RasA3"
                     /note="C2 domain second repeat present in RAS p21 protein
                     activator 3 (RasA3); cd04010"
                     /db_xref="CDD:175977"
     Site            order(197,209,262,264,285,287)
                     /site_type="other"
                     /note="putative Ca2+ binding pocket [ion binding]"
                     /db_xref="CDD:175977"
     Region          341..609
                     /region_name="RasGAP_RASA3"
                     /note="Ras-GTPase Activating Domain of RASA3; cd05134"
                     /db_xref="CDD:213336"
     Site            order(375,411,413,415..416,418,421,425,520,528..529,
                     532..533,536,557,560..561,564,568,570,578..579)
                     /site_type="other"
                     /note="putative RAS interface [polypeptide binding]"
                     /db_xref="CDD:213336"
     Region          606..730
                     /region_name="PH_GAP1_mammal-like"
                     /note="GAP1(IP4BP) pleckstrin homology (PH) domain;
                     cd13371"
                     /db_xref="CDD:241522"
     Region          723..758
                     /region_name="BTK"
                     /note="Bruton's tyrosine kinase Cys-rich motif;
                     smart00107"
                     /db_xref="CDD:128417"
     CDS             1..878
                     /gene="RASA3"
                     /gene_synonym="GAP1IP4BP; GAPIII"
                     /coded_by="XM_047430156.1:12..2648"
                     /db_xref="GeneID:22821"
                     /db_xref="HGNC:HGNC:20331"
                     /db_xref="MIM:605182"
ORIGIN      
        1 mrtirnccas srkcsrkerr srrlrgqspa grlegsstrd sglarlccpg rrswglslhr
       61 cageaknlps ypgpskmrdc yctvnldqee vfrtkiveks lcpfygedfy ceiprsfrhl
      121 sfyifdrdvf rrdsiigkva iqkedlqkyh nrdtwfqlqh vdadsevqgk vhlelrlsev
      181 itdtgvvchk latrivecqg lpivngqcdp yatvtlagpf rseakktkvk rktnnpqfde
      241 vfyfevtrpc syskkshfdf eeedvdklei rvdlwnasnl kfgdeflgel riplkvlrqs
      301 ssyeawyflq prdngskslk pddlgslrln vvytedhvfs sdyysplrdl llksadvepv
      361 sasaahilge vcrekqeaav plvrlflhyg rvvpfisaia saevkrtqdp ntifrgnsla
      421 skcidetmkl agmhylhvtl kpaieeicqs hkpceidpvk lkdgenlenn menlrqyvdr
      481 vfhaitesgv scptvmcdif fslreaaakr fqddpdvryt avssfiflrf fapailspnl
      541 fqltphhtdp qtsrtltlis ktvqtlgsls ksksasfkes ymatfyeffn eqkyadavkn
      601 fldlisssgr rdpksveqpi vlkegfmikr aqgrkrfgmk nfkkrwfrlt nheftyhksk
      661 gdqplysipi enilavekle eesfkmknmf qviqperaly iqanncveak dwidiltkvs
      721 qcnqkrltvy hpsaylsghw lccrapsdsa pgcspctggl paniqldidg dreteriysl
      781 fnlymsklek mqeacgsksv ydgpeqeeys tfviddpqet yktlkqviag vgaleqehaq
      841 ykrdkfkktk ygsqehpigd ksfqnyirqq setsthsi
//
LOCUS       XP_011533144             802 aa            linear   PRI 05-AUG-2025
DEFINITION  ras GTPase-activating protein 3 isoform X2 [Homo sapiens].
ACCESSION   XP_011533144
VERSION     XP_011533144.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534842.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..802
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..802
                     /product="ras GTPase-activating protein 3 isoform X2"
                     /calculated_mol_wt=92097
     Region          1..101
                     /region_name="C2A_RasA2_RasA3"
                     /note="C2 domain first repeat present in RasA2 and RasA3;
                     cd08401"
                     /db_xref="CDD:176046"
     Site            order(3,50,52,57)
                     /site_type="other"
                     /note="putative Ca2+ binding site [ion binding]"
                     /db_xref="CDD:176046"
     Region          114..256
                     /region_name="C2B_RasA3"
                     /note="C2 domain second repeat present in RAS p21 protein
                     activator 3 (RasA3); cd04010"
                     /db_xref="CDD:175977"
     Site            order(121,133,186,188,209,211)
                     /site_type="other"
                     /note="putative Ca2+ binding pocket [ion binding]"
                     /db_xref="CDD:175977"
     Region          265..533
                     /region_name="RasGAP_RASA3"
                     /note="Ras-GTPase Activating Domain of RASA3; cd05134"
                     /db_xref="CDD:213336"
     Site            order(299,335,337,339..340,342,345,349,444,452..453,
                     456..457,460,481,484..485,488,492,494,502..503)
                     /site_type="other"
                     /note="putative RAS interface [polypeptide binding]"
                     /db_xref="CDD:213336"
     Region          530..654
                     /region_name="PH_GAP1_mammal-like"
                     /note="GAP1(IP4BP) pleckstrin homology (PH) domain;
                     cd13371"
                     /db_xref="CDD:241522"
     Region          647..682
                     /region_name="BTK"
                     /note="Bruton's tyrosine kinase Cys-rich motif;
                     smart00107"
                     /db_xref="CDD:128417"
     CDS             1..802
                     /gene="RASA3"
                     /gene_synonym="GAP1IP4BP; GAPIII"
                     /coded_by="XM_011534842.3:199..2607"
                     /db_xref="GeneID:22821"
                     /db_xref="HGNC:HGNC:20331"
                     /db_xref="MIM:605182"
ORIGIN      
        1 mrdcyctvnl dqeevfrtki vekslcpfyg edfyceiprs frhlsfyifd rdvfrrdsii
       61 gkvaiqkedl qkyhnrdtwf qlqhvdadse vqgkvhlelr lsevitdtgv vchklatriv
      121 ecqglpivng qcdpyatvtl agpfrseakk tkvkrktnnp qfdevfyfev trpcsyskks
      181 hfdfeeedvd kleirvdlwn asnlkfgdef lgelriplkv lrqsssyeaw yflqprdngs
      241 kslkpddlgs lrlnvvyted hvfssdyysp lrdlllksad vepvsasaah ilgevcrekq
      301 eaavplvrlf lhygrvvpfi saiasaevkr tqdpntifrg nslaskcide tmklagmhyl
      361 hvtlkpaiee icqshkpcei dpvklkdgen lennmenlrq yvdrvfhait esgvscptvm
      421 cdiffslrea aakrfqddpd vrytavssfi flrffapail spnlfqltph htdpqtsrtl
      481 tlisktvqtl gslsksksas fkesymatfy effneqkyad avknfldlis ssgrrdpksv
      541 eqpivlkegf mikraqgrkr fgmknfkkrw frltnhefty hkskgdqply sipienilav
      601 ekleeesfkm knmfqviqpe ralyiqannc veakdwidil tkvsqcnqkr ltvyhpsayl
      661 sghwlccrap sdsapgcspc tgglpaniql didgdreter iyslfnlyms klekmqeacg
      721 sksvydgpeq eeystfvidd pqetyktlkq viagvgaleq ehaqykrdkf kktkygsqeh
      781 pigdksfqny irqqsetsth si
//
LOCUS       XP_047286113             451 aa            linear   PRI 05-AUG-2025
DEFINITION  ras GTPase-activating protein 3 isoform X4 [Homo sapiens].
ACCESSION   XP_047286113
VERSION     XP_047286113.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430157.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..451
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..451
                     /product="ras GTPase-activating protein 3 isoform X4"
                     /calculated_mol_wt=51648
     Region          <1..182
                     /region_name="RasGAP"
                     /note="Ras GTPase Activating Domain; cl02569"
                     /db_xref="CDD:470620"
     Region          179..303
                     /region_name="PH_GAP1_mammal-like"
                     /note="GAP1(IP4BP) pleckstrin homology (PH) domain;
                     cd13371"
                     /db_xref="CDD:241522"
     Region          296..331
                     /region_name="BTK"
                     /note="Bruton's tyrosine kinase Cys-rich motif;
                     smart00107"
                     /db_xref="CDD:128417"
     CDS             1..451
                     /gene="RASA3"
                     /gene_synonym="GAP1IP4BP; GAPIII"
                     /coded_by="XM_047430157.1:1166..2521"
                     /db_xref="GeneID:22821"
                     /db_xref="HGNC:HGNC:20331"
                     /db_xref="MIM:605182"
ORIGIN      
        1 mklagmhylh vtlkpaieei cqshkpceid pvklkdgenl ennmenlrqy vdrvfhaite
       61 sgvscptvmc diffslreaa akrfqddpdv rytavssfif lrffapails pnlfqltphh
      121 tdpqtsrtlt lisktvqtlg slsksksasf kesymatfye ffneqkyada vknfldliss
      181 sgrrdpksve qpivlkegfm ikraqgrkrf gmknfkkrwf rltnheftyh kskgdqplys
      241 ipienilave kleeesfkmk nmfqviqper alyiqanncv eakdwidilt kvsqcnqkrl
      301 tvyhpsayls ghwlccraps dsapgcspct gglpaniqld idgdreteri yslfnlymsk
      361 lekmqeacgs ksvydgpeqe eystfviddp qetyktlkqv iagvgaleqe haqykrdkfk
      421 ktkygsqehp igdksfqnyi rqqsetsths i
//
LOCUS       XP_047286114             451 aa            linear   PRI 05-AUG-2025
DEFINITION  ras GTPase-activating protein 3 isoform X4 [Homo sapiens].
ACCESSION   XP_047286114
VERSION     XP_047286114.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430158.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..451
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..451
                     /product="ras GTPase-activating protein 3 isoform X4"
                     /calculated_mol_wt=51648
     Region          <1..182
                     /region_name="RasGAP"
                     /note="Ras GTPase Activating Domain; cl02569"
                     /db_xref="CDD:470620"
     Region          179..303
                     /region_name="PH_GAP1_mammal-like"
                     /note="GAP1(IP4BP) pleckstrin homology (PH) domain;
                     cd13371"
                     /db_xref="CDD:241522"
     Region          296..331
                     /region_name="BTK"
                     /note="Bruton's tyrosine kinase Cys-rich motif;
                     smart00107"
                     /db_xref="CDD:128417"
     CDS             1..451
                     /gene="RASA3"
                     /gene_synonym="GAP1IP4BP; GAPIII"
                     /coded_by="XM_047430158.1:1018..2373"
                     /db_xref="GeneID:22821"
                     /db_xref="HGNC:HGNC:20331"
                     /db_xref="MIM:605182"
ORIGIN      
        1 mklagmhylh vtlkpaieei cqshkpceid pvklkdgenl ennmenlrqy vdrvfhaite
       61 sgvscptvmc diffslreaa akrfqddpdv rytavssfif lrffapails pnlfqltphh
      121 tdpqtsrtlt lisktvqtlg slsksksasf kesymatfye ffneqkyada vknfldliss
      181 sgrrdpksve qpivlkegfm ikraqgrkrf gmknfkkrwf rltnheftyh kskgdqplys
      241 ipienilave kleeesfkmk nmfqviqper alyiqanncv eakdwidilt kvsqcnqkrl
      301 tvyhpsayls ghwlccraps dsapgcspct gglpaniqld idgdreteri yslfnlymsk
      361 lekmqeacgs ksvydgpeqe eystfviddp qetyktlkqv iagvgaleqe haqykrdkfk
      421 ktkygsqehp igdksfqnyi rqqsetsths i
//
LOCUS       XP_047286115             485 aa            linear   PRI 05-AUG-2025
DEFINITION  ras GTPase-activating protein 3 isoform X5 [Homo sapiens].
ACCESSION   XP_047286115
VERSION     XP_047286115.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430159.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..485
                     /product="ras GTPase-activating protein 3 isoform X5"
                     /calculated_mol_wt=55725
     Region          1..101
                     /region_name="C2A_RasA2_RasA3"
                     /note="C2 domain first repeat present in RasA2 and RasA3;
                     cd08401"
                     /db_xref="CDD:176046"
     Site            order(3,50,52,57)
                     /site_type="other"
                     /note="putative Ca2+ binding site [ion binding]"
                     /db_xref="CDD:176046"
     Region          114..256
                     /region_name="C2B_RasA3"
                     /note="C2 domain second repeat present in RAS p21 protein
                     activator 3 (RasA3); cd04010"
                     /db_xref="CDD:175977"
     Site            order(121,133,186,188,209,211)
                     /site_type="other"
                     /note="putative Ca2+ binding pocket [ion binding]"
                     /db_xref="CDD:175977"
     Region          265..>472
                     /region_name="RasGAP"
                     /note="Ras GTPase Activating Domain; cl02569"
                     /db_xref="CDD:470620"
     CDS             1..485
                     /gene="RASA3"
                     /gene_synonym="GAP1IP4BP; GAPIII"
                     /coded_by="XM_047430159.1:42..1499"
                     /db_xref="GeneID:22821"
                     /db_xref="HGNC:HGNC:20331"
                     /db_xref="MIM:605182"
ORIGIN      
        1 mrdcyctvnl dqeevfrtki vekslcpfyg edfyceiprs frhlsfyifd rdvfrrdsii
       61 gkvaiqkedl qkyhnrdtwf qlqhvdadse vqgkvhlelr lsevitdtgv vchklatriv
      121 ecqglpivng qcdpyatvtl agpfrseakk tkvkrktnnp qfdevfyfev trpcsyskks
      181 hfdfeeedvd kleirvdlwn asnlkfgdef lgelriplkv lrqsssyeaw yflqprdngs
      241 kslkpddlgs lrlnvvyted hvfssdyysp lrdlllksad vepvsasaah ilgevcrekq
      301 eaavplvrlf lhygrvvpfi saiasaevkr tqdpntifrg nslaskcide tmklagmhyl
      361 hvtlkpaiee icqshkpcei dpvklkdgen lennmenlrq yvdrvfhait esgvscptvm
      421 cdiffslrea aakrfqddpd vrytavssfi flrffapail spnlfqltph htkihvknlp
      481 hlres
//
LOCUS       XP_047286116             451 aa            linear   PRI 05-AUG-2025
DEFINITION  ras GTPase-activating protein 3 isoform X4 [Homo sapiens].
ACCESSION   XP_047286116
VERSION     XP_047286116.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430160.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..451
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..451
                     /product="ras GTPase-activating protein 3 isoform X4"
                     /calculated_mol_wt=51648
     Region          <1..182
                     /region_name="RasGAP"
                     /note="Ras GTPase Activating Domain; cl02569"
                     /db_xref="CDD:470620"
     Region          179..303
                     /region_name="PH_GAP1_mammal-like"
                     /note="GAP1(IP4BP) pleckstrin homology (PH) domain;
                     cd13371"
                     /db_xref="CDD:241522"
     Region          296..331
                     /region_name="BTK"
                     /note="Bruton's tyrosine kinase Cys-rich motif;
                     smart00107"
                     /db_xref="CDD:128417"
     CDS             1..451
                     /gene="RASA3"
                     /gene_synonym="GAP1IP4BP; GAPIII"
                     /coded_by="XM_047430160.1:9016..10371"
                     /db_xref="GeneID:22821"
                     /db_xref="HGNC:HGNC:20331"
                     /db_xref="MIM:605182"
ORIGIN      
        1 mklagmhylh vtlkpaieei cqshkpceid pvklkdgenl ennmenlrqy vdrvfhaite
       61 sgvscptvmc diffslreaa akrfqddpdv rytavssfif lrffapails pnlfqltphh
      121 tdpqtsrtlt lisktvqtlg slsksksasf kesymatfye ffneqkyada vknfldliss
      181 sgrrdpksve qpivlkegfm ikraqgrkrf gmknfkkrwf rltnheftyh kskgdqplys
      241 ipienilave kleeesfkmk nmfqviqper alyiqanncv eakdwidilt kvsqcnqkrl
      301 tvyhpsayls ghwlccraps dsapgcspct gglpaniqld idgdreteri yslfnlymsk
      361 lekmqeacgs ksvydgpeqe eystfviddp qetyktlkqv iagvgaleqe haqykrdkfk
      421 ktkygsqehp igdksfqnyi rqqsetsths i
//
LOCUS       XP_047286117             451 aa            linear   PRI 05-AUG-2025
DEFINITION  ras GTPase-activating protein 3 isoform X4 [Homo sapiens].
ACCESSION   XP_047286117
VERSION     XP_047286117.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430161.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..451
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..451
                     /product="ras GTPase-activating protein 3 isoform X4"
                     /calculated_mol_wt=51648
     Region          <1..182
                     /region_name="RasGAP"
                     /note="Ras GTPase Activating Domain; cl02569"
                     /db_xref="CDD:470620"
     Region          179..303
                     /region_name="PH_GAP1_mammal-like"
                     /note="GAP1(IP4BP) pleckstrin homology (PH) domain;
                     cd13371"
                     /db_xref="CDD:241522"
     Region          296..331
                     /region_name="BTK"
                     /note="Bruton's tyrosine kinase Cys-rich motif;
                     smart00107"
                     /db_xref="CDD:128417"
     CDS             1..451
                     /gene="RASA3"
                     /gene_synonym="GAP1IP4BP; GAPIII"
                     /coded_by="XM_047430161.1:1484..2839"
                     /db_xref="GeneID:22821"
                     /db_xref="HGNC:HGNC:20331"
                     /db_xref="MIM:605182"
ORIGIN      
        1 mklagmhylh vtlkpaieei cqshkpceid pvklkdgenl ennmenlrqy vdrvfhaite
       61 sgvscptvmc diffslreaa akrfqddpdv rytavssfif lrffapails pnlfqltphh
      121 tdpqtsrtlt lisktvqtlg slsksksasf kesymatfye ffneqkyada vknfldliss
      181 sgrrdpksve qpivlkegfm ikraqgrkrf gmknfkkrwf rltnheftyh kskgdqplys
      241 ipienilave kleeesfkmk nmfqviqper alyiqanncv eakdwidilt kvsqcnqkrl
      301 tvyhpsayls ghwlccraps dsapgcspct gglpaniqld idgdreteri yslfnlymsk
      361 lekmqeacgs ksvydgpeqe eystfviddp qetyktlkqv iagvgaleqe haqykrdkfk
      421 ktkygsqehp igdksfqnyi rqqsetsths i
//
LOCUS       XP_047286118             451 aa            linear   PRI 05-AUG-2025
DEFINITION  ras GTPase-activating protein 3 isoform X4 [Homo sapiens].
ACCESSION   XP_047286118
VERSION     XP_047286118.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430162.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..451
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..451
                     /product="ras GTPase-activating protein 3 isoform X4"
                     /calculated_mol_wt=51648
     Region          <1..182
                     /region_name="RasGAP"
                     /note="Ras GTPase Activating Domain; cl02569"
                     /db_xref="CDD:470620"
     Region          179..303
                     /region_name="PH_GAP1_mammal-like"
                     /note="GAP1(IP4BP) pleckstrin homology (PH) domain;
                     cd13371"
                     /db_xref="CDD:241522"
     Region          296..331
                     /region_name="BTK"
                     /note="Bruton's tyrosine kinase Cys-rich motif;
                     smart00107"
                     /db_xref="CDD:128417"
     CDS             1..451
                     /gene="RASA3"
                     /gene_synonym="GAP1IP4BP; GAPIII"
                     /coded_by="XM_047430162.1:8995..10350"
                     /db_xref="GeneID:22821"
                     /db_xref="HGNC:HGNC:20331"
                     /db_xref="MIM:605182"
ORIGIN      
        1 mklagmhylh vtlkpaieei cqshkpceid pvklkdgenl ennmenlrqy vdrvfhaite
       61 sgvscptvmc diffslreaa akrfqddpdv rytavssfif lrffapails pnlfqltphh
      121 tdpqtsrtlt lisktvqtlg slsksksasf kesymatfye ffneqkyada vknfldliss
      181 sgrrdpksve qpivlkegfm ikraqgrkrf gmknfkkrwf rltnheftyh kskgdqplys
      241 ipienilave kleeesfkmk nmfqviqper alyiqanncv eakdwidilt kvsqcnqkrl
      301 tvyhpsayls ghwlccraps dsapgcspct gglpaniqld idgdreteri yslfnlymsk
      361 lekmqeacgs ksvydgpeqe eystfviddp qetyktlkqv iagvgaleqe haqykrdkfk
      421 ktkygsqehp igdksfqnyi rqqsetsths i
//
LOCUS       XP_047286119             451 aa            linear   PRI 05-AUG-2025
DEFINITION  ras GTPase-activating protein 3 isoform X4 [Homo sapiens].
ACCESSION   XP_047286119
VERSION     XP_047286119.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430163.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..451
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..451
                     /product="ras GTPase-activating protein 3 isoform X4"
                     /calculated_mol_wt=51648
     Region          <1..182
                     /region_name="RasGAP"
                     /note="Ras GTPase Activating Domain; cl02569"
                     /db_xref="CDD:470620"
     Region          179..303
                     /region_name="PH_GAP1_mammal-like"
                     /note="GAP1(IP4BP) pleckstrin homology (PH) domain;
                     cd13371"
                     /db_xref="CDD:241522"
     Region          296..331
                     /region_name="BTK"
                     /note="Bruton's tyrosine kinase Cys-rich motif;
                     smart00107"
                     /db_xref="CDD:128417"
     CDS             1..451
                     /gene="RASA3"
                     /gene_synonym="GAP1IP4BP; GAPIII"
                     /coded_by="XM_047430163.1:8792..10147"
                     /db_xref="GeneID:22821"
                     /db_xref="HGNC:HGNC:20331"
                     /db_xref="MIM:605182"
ORIGIN      
        1 mklagmhylh vtlkpaieei cqshkpceid pvklkdgenl ennmenlrqy vdrvfhaite
       61 sgvscptvmc diffslreaa akrfqddpdv rytavssfif lrffapails pnlfqltphh
      121 tdpqtsrtlt lisktvqtlg slsksksasf kesymatfye ffneqkyada vknfldliss
      181 sgrrdpksve qpivlkegfm ikraqgrkrf gmknfkkrwf rltnheftyh kskgdqplys
      241 ipienilave kleeesfkmk nmfqviqper alyiqanncv eakdwidilt kvsqcnqkrl
      301 tvyhpsayls ghwlccraps dsapgcspct gglpaniqld idgdreteri yslfnlymsk
      361 lekmqeacgs ksvydgpeqe eystfviddp qetyktlkqv iagvgaleqe haqykrdkfk
      421 ktkygsqehp igdksfqnyi rqqsetsths i
//
LOCUS       XP_016875929            1198 aa            linear   PRI 05-AUG-2025
DEFINITION  fibronectin type-III domain-containing protein 3A isoform X1 [Homo
            sapiens].
ACCESSION   XP_016875929
VERSION     XP_016875929.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020440.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1198
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1198
                     /product="fibronectin type-III domain-containing protein
                     3A isoform X1"
                     /calculated_mol_wt=131721
     Region          267..366
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(355..356,358..359)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          371..462
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(371,435,450)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Site            order(451..452,454..455)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          <466..855
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     Region          <811..>1070
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     CDS             1..1198
                     /gene="FNDC3A"
                     /gene_synonym="bA203I16.1; bA203I16.5; FNDC3; HUGO"
                     /coded_by="XM_017020440.3:141..3737"
                     /db_xref="GeneID:22862"
                     /db_xref="HGNC:HGNC:20296"
                     /db_xref="MIM:615794"
ORIGIN      
        1 maehpplldt tqilssdisl lsapivsadg tqqvilvqvn pgeaftirre dgqfqcitgp
       61 aqvpmmspng svppiyvppg yapqviedng vrrvvvvpqa pefhpgshtv lhrsphpplp
      121 gfipvptmmp ppprhmyspv tgagdmttqy mpqyqssqvy gdvdahsthg rsnfrderss
      181 ktyerlqkkl kdrqgtqkdk mssppsspqk cpspinehng likgqiaggi ntgsakiksg
      241 kgkggtqvdt eieekdeetk afeallsniv kpvasdiqar tvvltwspps slingetdes
      301 svpelygyev lisstgkdgk yksvyvgeet nitlndlkpa mdyhakvqae ynsikgtpse
      361 aeifttlsce pdipnppria nrtknsltlq wkapsdngsk iqnfvlewde gkgngefcqc
      421 ymgsqkqfki tklspamgck frlsarndyg tsgfseevly ytsgcapsmp aspvltkagi
      481 twlslqwskp sgtpsdegis yilemeeets gygfkpkydg edlaytvknl rrstkykfkv
      541 iaynsegksn psevvefttc pdkpgipvkp svkgkihshs fkitwdppkd nggatinkyv
      601 vemaegsngn kwemiysgat rehlcdrlnp gcfyrlrvyc isdggqsavs esllvqtpav
      661 ppgpclpprl qgrpkakeiq lrwgpplvdg gspiscysve mspiekdepr evyqgsevec
      721 tvssllpgkt ysfrlraank mgfgpfsekc dittapgppd qckppqvtcr satcaqvnwe
      781 vplsngtdvt eyrlewggve gsmqicycgp glsyeikgls pattyycrvq alsvvgagpf
      841 sevvacvtpp svpgivtclq eisddeienp hyspstclai swekpcdhgs eilaysidfg
      901 dkqsltvgkv tsyiinnlqp dttyririqa lnslgagpfs hmiklktkpl ppdpprlecv
      961 afshqnlklk wgegtpktls tdsiqyhlqm edkngrfvsl yrgpchtykv qrlnestsyk
     1021 fciqacneag egplsqeyif ttpksvpaal kapkiekvnd hiceitwecl qpmkgdpviy
     1081 slqvmlgkds efkqiykgpd ssfrysslql nceyrfrvca irqcqdslgh qdlvgpystt
     1141 vlfisqrtep pastnrdtve strtrralsd eqcaavilvl faffsiliaf iiqyfvik
//
LOCUS       XP_011533299            1134 aa            linear   PRI 05-AUG-2025
DEFINITION  fibronectin type-III domain-containing protein 3A isoform X2 [Homo
            sapiens].
ACCESSION   XP_011533299
VERSION     XP_011533299.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534997.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1134
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1134
                     /product="fibronectin type-III domain-containing protein
                     3A isoform X2"
                     /calculated_mol_wt=124923
     Region          203..302
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(291..292,294..295)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          307..398
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(307,371,386)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Site            order(387..388,390..391)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          <402..791
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     Region          <747..>1006
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     CDS             1..1134
                     /gene="FNDC3A"
                     /gene_synonym="bA203I16.1; bA203I16.5; FNDC3; HUGO"
                     /coded_by="XM_011534997.4:77..3481"
                     /db_xref="GeneID:22862"
                     /db_xref="HGNC:HGNC:20296"
                     /db_xref="MIM:615794"
ORIGIN      
        1 mmspngsvpp iyvppgyapq viedngvrrv vvvpqapefh pgshtvlhrs phpplpgfip
       61 vptmmppppr hmyspvtgag dmttqympqy qssqvygdvd ahsthgrsnf rderssktye
      121 rlqkklkdrq gtqkdkmssp psspqkcpsp inehnglikg qiaggintgs akiksgkgkg
      181 gtqvdteiee kdeetkafea llsnivkpva sdiqartvvl twsppsslin getdessvpe
      241 lygyevliss tgkdgkyksv yvgeetnitl ndlkpamdyh akvqaeynsi kgtpseaeif
      301 ttlscepdip npprianrtk nsltlqwkap sdngskiqnf vlewdegkgn gefcqcymgs
      361 qkqfkitkls pamgckfrls arndygtsgf seevlyytsg capsmpaspv ltkagitwls
      421 lqwskpsgtp sdegisyile meeetsgygf kpkydgedla ytvknlrrst kykfkviayn
      481 segksnpsev vefttcpdkp gipvkpsvkg kihshsfkit wdppkdngga tinkyvvema
      541 egsngnkwem iysgatrehl cdrlnpgcfy rlrvycisdg gqsavsesll vqtpavppgp
      601 clpprlqgrp kakeiqlrwg pplvdggspi scysvemspi ekdeprevyq gsevectvss
      661 llpgktysfr lraankmgfg pfsekcditt apgppdqckp pqvtcrsatc aqvnwevpls
      721 ngtdvteyrl ewggvegsmq icycgpglsy eikglspatt yycrvqalsv vgagpfsevv
      781 acvtppsvpg ivtclqeisd deienphysp stclaiswek pcdhgseila ysidfgdkqs
      841 ltvgkvtsyi innlqpdtty ririqalnsl gagpfshmik lktkplppdp prlecvafsh
      901 qnlklkwgeg tpktlstdsi qyhlqmedkn grfvslyrgp chtykvqrln estsykfciq
      961 acneagegpl sqeyifttpk svpaalkapk iekvndhice itweclqpmk gdpviyslqv
     1021 mlgkdsefkq iykgpdssfr ysslqlncey rfrvcairqc qdslghqdlv gpysttvlfi
     1081 sqrteppast nrdtvestrt rralsdeqca avilvlfaff siliafiiqy fvik
//
LOCUS       XP_016875932            1041 aa            linear   PRI 05-AUG-2025
DEFINITION  fibronectin type-III domain-containing protein 3A isoform X3 [Homo
            sapiens].
ACCESSION   XP_016875932
VERSION     XP_016875932.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020443.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1041
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1041
                     /product="fibronectin type-III domain-containing protein
                     3A isoform X3"
                     /calculated_mol_wt=114228
     Region          267..366
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(355..356,358..359)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          371..462
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(371,435,450)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Site            order(451..452,454..455)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          <466..855
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     Region          <811..>971
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     CDS             1..1041
                     /gene="FNDC3A"
                     /gene_synonym="bA203I16.1; bA203I16.5; FNDC3; HUGO"
                     /coded_by="XM_017020443.2:296..3421"
                     /db_xref="GeneID:22862"
                     /db_xref="HGNC:HGNC:20296"
                     /db_xref="MIM:615794"
ORIGIN      
        1 maehpplldt tqilssdisl lsapivsadg tqqvilvqvn pgeaftirre dgqfqcitgp
       61 aqvpmmspng svppiyvppg yapqviedng vrrvvvvpqa pefhpgshtv lhrsphpplp
      121 gfipvptmmp ppprhmyspv tgagdmttqy mpqyqssqvy gdvdahsthg rsnfrderss
      181 ktyerlqkkl kdrqgtqkdk mssppsspqk cpspinehng likgqiaggi ntgsakiksg
      241 kgkggtqvdt eieekdeetk afeallsniv kpvasdiqar tvvltwspps slingetdes
      301 svpelygyev lisstgkdgk yksvyvgeet nitlndlkpa mdyhakvqae ynsikgtpse
      361 aeifttlsce pdipnppria nrtknsltlq wkapsdngsk iqnfvlewde gkgngefcqc
      421 ymgsqkqfki tklspamgck frlsarndyg tsgfseevly ytsgcapsmp aspvltkagi
      481 twlslqwskp sgtpsdegis yilemeeets gygfkpkydg edlaytvknl rrstkykfkv
      541 iaynsegksn psevvefttc pdkpgipvkp svkgkihshs fkitwdppkd nggatinkyv
      601 vemaegsngn kwemiysgat rehlcdrlnp gcfyrlrvyc isdggqsavs esllvqtpav
      661 ppgpclpprl qgrpkakeiq lrwgpplvdg gspiscysve mspiekdepr evyqgsevec
      721 tvssllpgkt ysfrlraank mgfgpfsekc dittapgppd qckppqvtcr satcaqvnwe
      781 vplsngtdvt eyrlewggve gsmqicycgp glsyeikgls pattyycrvq alsvvgagpf
      841 sevvacvtpp svpgivtclq eisddeienp hyspstclai swekpcdhgs eilaysidfg
      901 dkqsltvgkv tsyiinnlqp dttyririqa lnslgagpfs hmiklktkpl ppdpprlecv
      961 afshqnlklk wgegtpktls tdsiqyhlqm edkngrniqs kimgciqlid nilgeicmif
     1021 nfieqfkwvm ywkfyiiill l
//
LOCUS       XP_006719979             932 aa            linear   PRI 05-AUG-2025
DEFINITION  cilium assembly protein DZIP1 isoform X1 [Homo sapiens].
ACCESSION   XP_006719979
VERSION     XP_006719979.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006719916.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..932
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..932
                     /product="cilium assembly protein DZIP1 isoform X1"
                     /calculated_mol_wt=105857
     Region          104..224
                     /region_name="Dzip-like_N"
                     /note="Iguana/Dzip1-like DAZ-interacting protein
                     N-terminal; pfam13815"
                     /db_xref="CDD:433498"
     Region          <190..>486
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          246..267
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..932
                     /gene="DZIP1"
                     /gene_synonym="DZIP; DZIPt1; MMVP3; MVP3; SPGF47"
                     /coded_by="XM_006719916.1:856..3654"
                     /db_xref="GeneID:22873"
                     /db_xref="HGNC:HGNC:20908"
                     /db_xref="MIM:608671"
ORIGIN      
        1 mqaeaadwfs smvrggrpgr prrgcragen rgfpgppapq parppspppa alslcppqpf
       61 qkhvyyplas gpegpdvava aaaagaasma cappsaasgp lpffqfrprl esvdwrrlsa
      121 idvdkvagav dvltlqenim nitfcklede kcphcqsgvd pvllklirla qftieyllhs
      181 qefltsqlht leerlrlshc dgeqskkllt kqageiktlk eeckrrkkmi stqqlmieak
      241 anyyqchfcd kafmnqaflq shiqrrhtee nshfeyqkna qieklrseiv vlkeelqltr
      301 seleaahhas avrfskeyem qktkeedflk lfdrwkeeek eklvdemekv kemfmkefke
      361 ltsknsaley qlseiqksnm qiksnigtlk dahefkedrs pypqdfhnvm qlldsqeskw
      421 tarvqaihqe hkkekgrlls hieklrtsmi ddlnasnvfy kkrieelgqr lqeqneliit
      481 qrqqikdftc nplnsisepk gnplawqafe sqpaapavpm napalhtlet ksslpmvheq
      541 afsshilepi eelseeekgr eneqklnnnk mhlrkalksn ssltkglrtm veqnlmekle
      601 tlginadirg issdqlhrvl ksveserhkq ereipnfhqi reflehqvsc kieekallss
      661 dqcsvsqmdt lstgevpkmi qlpsknrqli rqkavstdrt svpkikknvm edpfprksst
      721 ittppfssee eqedddlira yaspgplpvp ppqnkgsfgk ntvksdadgt egseiedtdd
      781 spkpagvavk tptekvekmf phrknvnkpv ggtnvpemfi kkeelqelkc advededwdi
      841 ssleeeislg kksgkeqkep ppaknephfa hvlnawgafn pkgpkgegll lspliqarsi
      901 fllvvfhlyk ylinlcwyii rqkscqcfly vi
//
LOCUS       XP_047286121             932 aa            linear   PRI 05-AUG-2025
DEFINITION  cilium assembly protein DZIP1 isoform X1 [Homo sapiens].
ACCESSION   XP_047286121
VERSION     XP_047286121.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430165.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..932
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..932
                     /product="cilium assembly protein DZIP1 isoform X1"
                     /calculated_mol_wt=105857
     Region          104..224
                     /region_name="Dzip-like_N"
                     /note="Iguana/Dzip1-like DAZ-interacting protein
                     N-terminal; pfam13815"
                     /db_xref="CDD:433498"
     Region          <190..>486
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          246..267
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..932
                     /gene="DZIP1"
                     /gene_synonym="DZIP; DZIPt1; MMVP3; MVP3; SPGF47"
                     /coded_by="XM_047430165.1:1534..4332"
                     /db_xref="GeneID:22873"
                     /db_xref="HGNC:HGNC:20908"
                     /db_xref="MIM:608671"
ORIGIN      
        1 mqaeaadwfs smvrggrpgr prrgcragen rgfpgppapq parppspppa alslcppqpf
       61 qkhvyyplas gpegpdvava aaaagaasma cappsaasgp lpffqfrprl esvdwrrlsa
      121 idvdkvagav dvltlqenim nitfcklede kcphcqsgvd pvllklirla qftieyllhs
      181 qefltsqlht leerlrlshc dgeqskkllt kqageiktlk eeckrrkkmi stqqlmieak
      241 anyyqchfcd kafmnqaflq shiqrrhtee nshfeyqkna qieklrseiv vlkeelqltr
      301 seleaahhas avrfskeyem qktkeedflk lfdrwkeeek eklvdemekv kemfmkefke
      361 ltsknsaley qlseiqksnm qiksnigtlk dahefkedrs pypqdfhnvm qlldsqeskw
      421 tarvqaihqe hkkekgrlls hieklrtsmi ddlnasnvfy kkrieelgqr lqeqneliit
      481 qrqqikdftc nplnsisepk gnplawqafe sqpaapavpm napalhtlet ksslpmvheq
      541 afsshilepi eelseeekgr eneqklnnnk mhlrkalksn ssltkglrtm veqnlmekle
      601 tlginadirg issdqlhrvl ksveserhkq ereipnfhqi reflehqvsc kieekallss
      661 dqcsvsqmdt lstgevpkmi qlpsknrqli rqkavstdrt svpkikknvm edpfprksst
      721 ittppfssee eqedddlira yaspgplpvp ppqnkgsfgk ntvksdadgt egseiedtdd
      781 spkpagvavk tptekvekmf phrknvnkpv ggtnvpemfi kkeelqelkc advededwdi
      841 ssleeeislg kksgkeqkep ppaknephfa hvlnawgafn pkgpkgegll lspliqarsi
      901 fllvvfhlyk ylinlcwyii rqkscqcfly vi
//
LOCUS       XP_005254089             927 aa            linear   PRI 05-AUG-2025
DEFINITION  cilium assembly protein DZIP1 isoform X2 [Homo sapiens].
ACCESSION   XP_005254089
VERSION     XP_005254089.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254032.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..927
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..927
                     /product="cilium assembly protein DZIP1 isoform X2"
                     /calculated_mol_wt=105328
     Region          104..224
                     /region_name="Dzip-like_N"
                     /note="Iguana/Dzip1-like DAZ-interacting protein
                     N-terminal; pfam13815"
                     /db_xref="CDD:433498"
     Region          <190..>486
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          246..267
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..927
                     /gene="DZIP1"
                     /gene_synonym="DZIP; DZIPt1; MMVP3; MVP3; SPGF47"
                     /coded_by="XM_005254032.1:856..3639"
                     /db_xref="GeneID:22873"
                     /db_xref="HGNC:HGNC:20908"
                     /db_xref="MIM:608671"
ORIGIN      
        1 mqaeaadwfs smvrggrpgr prrgcragen rgfpgppapq parppspppa alslcppqpf
       61 qkhvyyplas gpegpdvava aaaagaasma cappsaasgp lpffqfrprl esvdwrrlsa
      121 idvdkvagav dvltlqenim nitfcklede kcphcqsgvd pvllklirla qftieyllhs
      181 qefltsqlht leerlrlshc dgeqskkllt kqageiktlk eeckrrkkmi stqqlmieak
      241 anyyqchfcd kafmnqaflq shiqrrhtee nshfeyqkna qieklrseiv vlkeelqltr
      301 seleaahhas avrfskeyem qktkeedflk lfdrwkeeek eklvdemekv kemfmkefke
      361 ltsknsaley qlseiqksnm qiksnigtlk dahefkedrs pypqdfhnvm qlldsqeskw
      421 tarvqaihqe hkkekgrlls hieklrtsmi ddlnasnvfy kkrieelgqr lqeqneliit
      481 qrqqikdftc nplnsisepk gnplawqafe sqpaapavpm napalhtlet ksslpmvheq
      541 afsshilepi eelseeekgr eneqklnnnk mhlrkalksn ssltkglrtm veqnlmekle
      601 tlginadirg issdqlhrvl ksveserhkq ereipnfhqi reflehqvsc kieekallss
      661 dqcsvsqmdt lstgevpkmi qlpsknrqli rqkavstdrt svpkikknvm edpfprksst
      721 itseeeqedd dlirayaspg plpvpppqnk gsfgkntvks dadgtegsei edtddspkpa
      781 gvavktptek vekmfphrkn vnkpvggtnv pemfikkeel qelkcadved edwdisslee
      841 eislgkksgk eqkepppakn ephfahvlna wgafnpkgpk geglllspli qarsifllvv
      901 fhlykylinl cwyiirqksc qcflyvi
//
LOCUS       XP_006719980             913 aa            linear   PRI 05-AUG-2025
DEFINITION  cilium assembly protein DZIP1 isoform X3 [Homo sapiens].
ACCESSION   XP_006719980
VERSION     XP_006719980.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006719917.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..913
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..913
                     /product="cilium assembly protein DZIP1 isoform X3"
                     /calculated_mol_wt=103249
     Region          104..224
                     /region_name="Dzip-like_N"
                     /note="Iguana/Dzip1-like DAZ-interacting protein
                     N-terminal; pfam13815"
                     /db_xref="CDD:433498"
     Region          <190..>486
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          244..268
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275369"
     Site            order(244,251,253..255,257..258,262,266)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275369"
     CDS             1..913
                     /gene="DZIP1"
                     /gene_synonym="DZIP; DZIPt1; MMVP3; MVP3; SPGF47"
                     /coded_by="XM_006719917.3:856..3597"
                     /db_xref="GeneID:22873"
                     /db_xref="HGNC:HGNC:20908"
                     /db_xref="MIM:608671"
ORIGIN      
        1 mqaeaadwfs smvrggrpgr prrgcragen rgfpgppapq parppspppa alslcppqpf
       61 qkhvyyplas gpegpdvava aaaagaasma cappsaasgp lpffqfrprl esvdwrrlsa
      121 idvdkvagav dvltlqenim nitfcklede kcphcqsgvd pvllklirla qftieyllhs
      181 qefltsqlht leerlrlshc dgeqskkllt kqageiktlk eeckrrkkmi stqqlmieak
      241 anyyqchfcd kafmnqaflq shiqrrhtee nshfeyqkna qieklrseiv vlkeelqltr
      301 seleaahhas avrfskeyem qktkeedflk lfdrwkeeek eklvdemekv kemfmkefke
      361 ltsknsaley qlseiqksnm qiksnigtlk dahefkedrs pypqdfhnvm qlldsqeskw
      421 tarvqaihqe hkkekgrlls hieklrtsmi ddlnasnvfy kkrieelgqr lqeqneliit
      481 qrqqikdftc nplnsisepk gnplawqafe sqpaapavpm napalhtlet ksslpmvheq
      541 afsshilepi eelseeekgr eneqklnnnk mhlrkalksn ssltkglrtm veqnlmekle
      601 tlginadirg issdqlhrvl ksveserhkq ereipnfhqi reflehqvsc kieekallss
      661 dqcsvsqmdt lstgevpkmi qlpsknrqli rqkavstdrt svpkikknvm edpfprksst
      721 ittppfssee eqedddlira yaspgplpvp ppqnkgsfgk ntvksdadgt egseiedtdd
      781 spkpagvavk tptekvekmf phrknvnkpv ggtnvpemfi kkeelqelkc advededwdi
      841 ssleeeislg kksgkeqkep ppaknephfa hvlnawgafn pkgpkgeglq enesstlkss
      901 lvtvtdwsdt sdv
//
LOCUS       XP_006719981             912 aa            linear   PRI 05-AUG-2025
DEFINITION  cilium assembly protein DZIP1 isoform X4 [Homo sapiens].
ACCESSION   XP_006719981
VERSION     XP_006719981.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006719918.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..912
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..912
                     /product="cilium assembly protein DZIP1 isoform X4"
                     /calculated_mol_wt=103531
     Region          104..224
                     /region_name="Dzip-like_N"
                     /note="Iguana/Dzip1-like DAZ-interacting protein
                     N-terminal; pfam13815"
                     /db_xref="CDD:433498"
     Region          <190..>486
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          246..267
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..912
                     /gene="DZIP1"
                     /gene_synonym="DZIP; DZIPt1; MMVP3; MVP3; SPGF47"
                     /coded_by="XM_006719918.1:856..3594"
                     /db_xref="GeneID:22873"
                     /db_xref="HGNC:HGNC:20908"
                     /db_xref="MIM:608671"
ORIGIN      
        1 mqaeaadwfs smvrggrpgr prrgcragen rgfpgppapq parppspppa alslcppqpf
       61 qkhvyyplas gpegpdvava aaaagaasma cappsaasgp lpffqfrprl esvdwrrlsa
      121 idvdkvagav dvltlqenim nitfcklede kcphcqsgvd pvllklirla qftieyllhs
      181 qefltsqlht leerlrlshc dgeqskkllt kqageiktlk eeckrrkkmi stqqlmieak
      241 anyyqchfcd kafmnqaflq shiqrrhtee nshfeyqkna qieklrseiv vlkeelqltr
      301 seleaahhas avrfskeyem qktkeedflk lfdrwkeeek eklvdemekv kemfmkefke
      361 ltsknsaley qlseiqksnm qiksnigtlk dahefkedrs pypqdfhnvm qlldsqeskw
      421 tarvqaihqe hkkekgrlls hieklrtsmi ddlnasnvfy kkrieelgqr lqeqneliit
      481 qrqqikdftc nplnsisepk gnplawqafe sqpaapavpm napalhtlet ksslpmvhgr
      541 eneqklnnnk mhlrkalksn ssltkglrtm veqnlmekle tlginadirg issdqlhrvl
      601 ksveserhkq ereipnfhqi reflehqvsc kieekallss dqcsvsqmdt lstgevpkmi
      661 qlpsknrqli rqkavstdrt svpkikknvm edpfprksst ittppfssee eqedddlira
      721 yaspgplpvp ppqnkgsfgk ntvksdadgt egseiedtdd spkpagvavk tptekvekmf
      781 phrknvnkpv ggtnvpemfi kkeelqelkc advededwdi ssleeeislg kksgkeqkep
      841 ppaknephfa hvlnawgafn pkgpkgegll lspliqarsi fllvvfhlyk ylinlcwyii
      901 rqkscqcfly vi
//
LOCUS       XP_047286122             908 aa            linear   PRI 05-AUG-2025
DEFINITION  cilium assembly protein DZIP1 isoform X5 [Homo sapiens].
ACCESSION   XP_047286122
VERSION     XP_047286122.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430166.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..908
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..908
                     /product="cilium assembly protein DZIP1 isoform X5"
                     /calculated_mol_wt=102720
     Region          104..224
                     /region_name="Dzip-like_N"
                     /note="Iguana/Dzip1-like DAZ-interacting protein
                     N-terminal; pfam13815"
                     /db_xref="CDD:433498"
     Region          <190..>486
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          244..268
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275369"
     Site            order(244,251,253..255,257..258,262,266)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275369"
     CDS             1..908
                     /gene="DZIP1"
                     /gene_synonym="DZIP; DZIPt1; MMVP3; MVP3; SPGF47"
                     /coded_by="XM_047430166.1:856..3582"
                     /db_xref="GeneID:22873"
                     /db_xref="HGNC:HGNC:20908"
                     /db_xref="MIM:608671"
ORIGIN      
        1 mqaeaadwfs smvrggrpgr prrgcragen rgfpgppapq parppspppa alslcppqpf
       61 qkhvyyplas gpegpdvava aaaagaasma cappsaasgp lpffqfrprl esvdwrrlsa
      121 idvdkvagav dvltlqenim nitfcklede kcphcqsgvd pvllklirla qftieyllhs
      181 qefltsqlht leerlrlshc dgeqskkllt kqageiktlk eeckrrkkmi stqqlmieak
      241 anyyqchfcd kafmnqaflq shiqrrhtee nshfeyqkna qieklrseiv vlkeelqltr
      301 seleaahhas avrfskeyem qktkeedflk lfdrwkeeek eklvdemekv kemfmkefke
      361 ltsknsaley qlseiqksnm qiksnigtlk dahefkedrs pypqdfhnvm qlldsqeskw
      421 tarvqaihqe hkkekgrlls hieklrtsmi ddlnasnvfy kkrieelgqr lqeqneliit
      481 qrqqikdftc nplnsisepk gnplawqafe sqpaapavpm napalhtlet ksslpmvheq
      541 afsshilepi eelseeekgr eneqklnnnk mhlrkalksn ssltkglrtm veqnlmekle
      601 tlginadirg issdqlhrvl ksveserhkq ereipnfhqi reflehqvsc kieekallss
      661 dqcsvsqmdt lstgevpkmi qlpsknrqli rqkavstdrt svpkikknvm edpfprksst
      721 itseeeqedd dlirayaspg plpvpppqnk gsfgkntvks dadgtegsei edtddspkpa
      781 gvavktptek vekmfphrkn vnkpvggtnv pemfikkeel qelkcadved edwdisslee
      841 eislgkksgk eqkepppakn ephfahvlna wgafnpkgpk geglqeness tlksslvtvt
      901 dwsdtsdv
//
LOCUS       XP_047286123             907 aa            linear   PRI 05-AUG-2025
DEFINITION  cilium assembly protein DZIP1 isoform X6 [Homo sapiens].
ACCESSION   XP_047286123
VERSION     XP_047286123.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430167.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..907
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..907
                     /product="cilium assembly protein DZIP1 isoform X6"
                     /calculated_mol_wt=103001
     Region          104..224
                     /region_name="Dzip-like_N"
                     /note="Iguana/Dzip1-like DAZ-interacting protein
                     N-terminal; pfam13815"
                     /db_xref="CDD:433498"
     Region          <190..>486
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          246..267
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..907
                     /gene="DZIP1"
                     /gene_synonym="DZIP; DZIPt1; MMVP3; MVP3; SPGF47"
                     /coded_by="XM_047430167.1:856..3579"
                     /db_xref="GeneID:22873"
                     /db_xref="HGNC:HGNC:20908"
                     /db_xref="MIM:608671"
ORIGIN      
        1 mqaeaadwfs smvrggrpgr prrgcragen rgfpgppapq parppspppa alslcppqpf
       61 qkhvyyplas gpegpdvava aaaagaasma cappsaasgp lpffqfrprl esvdwrrlsa
      121 idvdkvagav dvltlqenim nitfcklede kcphcqsgvd pvllklirla qftieyllhs
      181 qefltsqlht leerlrlshc dgeqskkllt kqageiktlk eeckrrkkmi stqqlmieak
      241 anyyqchfcd kafmnqaflq shiqrrhtee nshfeyqkna qieklrseiv vlkeelqltr
      301 seleaahhas avrfskeyem qktkeedflk lfdrwkeeek eklvdemekv kemfmkefke
      361 ltsknsaley qlseiqksnm qiksnigtlk dahefkedrs pypqdfhnvm qlldsqeskw
      421 tarvqaihqe hkkekgrlls hieklrtsmi ddlnasnvfy kkrieelgqr lqeqneliit
      481 qrqqikdftc nplnsisepk gnplawqafe sqpaapavpm napalhtlet ksslpmvhgr
      541 eneqklnnnk mhlrkalksn ssltkglrtm veqnlmekle tlginadirg issdqlhrvl
      601 ksveserhkq ereipnfhqi reflehqvsc kieekallss dqcsvsqmdt lstgevpkmi
      661 qlpsknrqli rqkavstdrt svpkikknvm edpfprksst itseeeqedd dlirayaspg
      721 plpvpppqnk gsfgkntvks dadgtegsei edtddspkpa gvavktptek vekmfphrkn
      781 vnkpvggtnv pemfikkeel qelkcadved edwdisslee eislgkksgk eqkepppakn
      841 ephfahvlna wgafnpkgpk geglllspli qarsifllvv fhlykylinl cwyiirqksc
      901 qcflyvi
//
LOCUS       XP_016875933             893 aa            linear   PRI 05-AUG-2025
DEFINITION  cilium assembly protein DZIP1 isoform X7 [Homo sapiens].
ACCESSION   XP_016875933
VERSION     XP_016875933.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020444.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..893
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..893
                     /product="cilium assembly protein DZIP1 isoform X7"
                     /calculated_mol_wt=100923
     Region          104..224
                     /region_name="Dzip-like_N"
                     /note="Iguana/Dzip1-like DAZ-interacting protein
                     N-terminal; pfam13815"
                     /db_xref="CDD:433498"
     Region          <190..>486
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          244..268
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275369"
     Site            order(244,251,253..255,257..258,262,266)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275369"
     CDS             1..893
                     /gene="DZIP1"
                     /gene_synonym="DZIP; DZIPt1; MMVP3; MVP3; SPGF47"
                     /coded_by="XM_017020444.2:856..3537"
                     /db_xref="GeneID:22873"
                     /db_xref="HGNC:HGNC:20908"
                     /db_xref="MIM:608671"
ORIGIN      
        1 mqaeaadwfs smvrggrpgr prrgcragen rgfpgppapq parppspppa alslcppqpf
       61 qkhvyyplas gpegpdvava aaaagaasma cappsaasgp lpffqfrprl esvdwrrlsa
      121 idvdkvagav dvltlqenim nitfcklede kcphcqsgvd pvllklirla qftieyllhs
      181 qefltsqlht leerlrlshc dgeqskkllt kqageiktlk eeckrrkkmi stqqlmieak
      241 anyyqchfcd kafmnqaflq shiqrrhtee nshfeyqkna qieklrseiv vlkeelqltr
      301 seleaahhas avrfskeyem qktkeedflk lfdrwkeeek eklvdemekv kemfmkefke
      361 ltsknsaley qlseiqksnm qiksnigtlk dahefkedrs pypqdfhnvm qlldsqeskw
      421 tarvqaihqe hkkekgrlls hieklrtsmi ddlnasnvfy kkrieelgqr lqeqneliit
      481 qrqqikdftc nplnsisepk gnplawqafe sqpaapavpm napalhtlet ksslpmvhgr
      541 eneqklnnnk mhlrkalksn ssltkglrtm veqnlmekle tlginadirg issdqlhrvl
      601 ksveserhkq ereipnfhqi reflehqvsc kieekallss dqcsvsqmdt lstgevpkmi
      661 qlpsknrqli rqkavstdrt svpkikknvm edpfprksst ittppfssee eqedddlira
      721 yaspgplpvp ppqnkgsfgk ntvksdadgt egseiedtdd spkpagvavk tptekvekmf
      781 phrknvnkpv ggtnvpemfi kkeelqelkc advededwdi ssleeeislg kksgkeqkep
      841 ppaknephfa hvlnawgafn pkgpkgeglq enesstlkss lvtvtdwsdt sdv
//
LOCUS       XP_047286124             888 aa            linear   PRI 05-AUG-2025
DEFINITION  cilium assembly protein DZIP1 isoform X8 [Homo sapiens].
ACCESSION   XP_047286124
VERSION     XP_047286124.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430168.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..888
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..888
                     /product="cilium assembly protein DZIP1 isoform X8"
                     /calculated_mol_wt=100393
     Region          104..224
                     /region_name="Dzip-like_N"
                     /note="Iguana/Dzip1-like DAZ-interacting protein
                     N-terminal; pfam13815"
                     /db_xref="CDD:433498"
     Region          <190..>486
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          244..268
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275369"
     Site            order(244,251,253..255,257..258,262,266)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275369"
     CDS             1..888
                     /gene="DZIP1"
                     /gene_synonym="DZIP; DZIPt1; MMVP3; MVP3; SPGF47"
                     /coded_by="XM_047430168.1:856..3522"
                     /db_xref="GeneID:22873"
                     /db_xref="HGNC:HGNC:20908"
                     /db_xref="MIM:608671"
ORIGIN      
        1 mqaeaadwfs smvrggrpgr prrgcragen rgfpgppapq parppspppa alslcppqpf
       61 qkhvyyplas gpegpdvava aaaagaasma cappsaasgp lpffqfrprl esvdwrrlsa
      121 idvdkvagav dvltlqenim nitfcklede kcphcqsgvd pvllklirla qftieyllhs
      181 qefltsqlht leerlrlshc dgeqskkllt kqageiktlk eeckrrkkmi stqqlmieak
      241 anyyqchfcd kafmnqaflq shiqrrhtee nshfeyqkna qieklrseiv vlkeelqltr
      301 seleaahhas avrfskeyem qktkeedflk lfdrwkeeek eklvdemekv kemfmkefke
      361 ltsknsaley qlseiqksnm qiksnigtlk dahefkedrs pypqdfhnvm qlldsqeskw
      421 tarvqaihqe hkkekgrlls hieklrtsmi ddlnasnvfy kkrieelgqr lqeqneliit
      481 qrqqikdftc nplnsisepk gnplawqafe sqpaapavpm napalhtlet ksslpmvhgr
      541 eneqklnnnk mhlrkalksn ssltkglrtm veqnlmekle tlginadirg issdqlhrvl
      601 ksveserhkq ereipnfhqi reflehqvsc kieekallss dqcsvsqmdt lstgevpkmi
      661 qlpsknrqli rqkavstdrt svpkikknvm edpfprksst itseeeqedd dlirayaspg
      721 plpvpppqnk gsfgkntvks dadgtegsei edtddspkpa gvavktptek vekmfphrkn
      781 vnkpvggtnv pemfikkeel qelkcadved edwdisslee eislgkksgk eqkepppakn
      841 ephfahvlna wgafnpkgpk geglqeness tlksslvtvt dwsdtsdv
//
LOCUS       XP_006719983             886 aa            linear   PRI 05-AUG-2025
DEFINITION  cilium assembly protein DZIP1 isoform X9 [Homo sapiens].
ACCESSION   XP_006719983
VERSION     XP_006719983.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006719920.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..886
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..886
                     /product="cilium assembly protein DZIP1 isoform X9"
                     /calculated_mol_wt=101141
     Region          58..178
                     /region_name="Dzip-like_N"
                     /note="Iguana/Dzip1-like DAZ-interacting protein
                     N-terminal; pfam13815"
                     /db_xref="CDD:433498"
     Region          <144..>440
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          200..221
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..886
                     /gene="DZIP1"
                     /gene_synonym="DZIP; DZIPt1; MMVP3; MVP3; SPGF47"
                     /coded_by="XM_006719920.1:856..3516"
                     /db_xref="GeneID:22873"
                     /db_xref="HGNC:HGNC:20908"
                     /db_xref="MIM:608671"
ORIGIN      
        1 mqaeaadwfs smpfqkhvyy plasgpegpd vavaaaaaga asmacappsa asgplpffqf
       61 rprlesvdwr rlsaidvdkv agavdvltlq enimnitfck ledekcphcq sgvdpvllkl
      121 irlaqftiey llhsqeflts qlhtleerlr lshcdgeqsk klltkqagei ktlkeeckrr
      181 kkmistqqlm ieakanyyqc hfcdkafmnq aflqshiqrr hteenshfey qknaqieklr
      241 seivvlkeel qltrseleaa hhasavrfsk eyemqktkee dflklfdrwk eeekeklvde
      301 mekvkemfmk efkeltskns aleyqlseiq ksnmqiksni gtlkdahefk edrspypqdf
      361 hnvmqlldsq eskwtarvqa ihqehkkekg rllshieklr tsmiddlnas nvfykkriee
      421 lgqrlqeqne liitqrqqik dftcnplnsi sepkgnplaw qafesqpaap avpmnapalh
      481 tletksslpm vheqafsshi lepieelsee ekgreneqkl nnnkmhlrka lksnssltkg
      541 lrtmveqnlm ekletlgina dirgissdql hrvlksvese rhkqereipn fhqirefleh
      601 qvsckieeka llssdqcsvs qmdtlstgev pkmiqlpskn rqlirqkavs tdrtsvpkik
      661 knvmedpfpr ksstittppf sseeeqeddd lirayaspgp lpvpppqnkg sfgkntvksd
      721 adgtegseie dtddspkpag vavktptekv ekmfphrknv nkpvggtnvp emfikkeelq
      781 elkcadvede dwdissleee islgkksgke qkepppakne phfahvlnaw gafnpkgpkg
      841 eglllspliq arsifllvvf hlykylinlc wyiirqkscq cflyvi
//
LOCUS       XP_047286125             886 aa            linear   PRI 05-AUG-2025
DEFINITION  cilium assembly protein DZIP1 isoform X9 [Homo sapiens].
ACCESSION   XP_047286125
VERSION     XP_047286125.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430169.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..886
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..886
                     /product="cilium assembly protein DZIP1 isoform X9"
                     /calculated_mol_wt=101141
     Region          58..178
                     /region_name="Dzip-like_N"
                     /note="Iguana/Dzip1-like DAZ-interacting protein
                     N-terminal; pfam13815"
                     /db_xref="CDD:433498"
     Region          <144..>440
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          200..221
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..886
                     /gene="DZIP1"
                     /gene_synonym="DZIP; DZIPt1; MMVP3; MVP3; SPGF47"
                     /coded_by="XM_047430169.1:1534..4194"
                     /db_xref="GeneID:22873"
                     /db_xref="HGNC:HGNC:20908"
                     /db_xref="MIM:608671"
ORIGIN      
        1 mqaeaadwfs smpfqkhvyy plasgpegpd vavaaaaaga asmacappsa asgplpffqf
       61 rprlesvdwr rlsaidvdkv agavdvltlq enimnitfck ledekcphcq sgvdpvllkl
      121 irlaqftiey llhsqeflts qlhtleerlr lshcdgeqsk klltkqagei ktlkeeckrr
      181 kkmistqqlm ieakanyyqc hfcdkafmnq aflqshiqrr hteenshfey qknaqieklr
      241 seivvlkeel qltrseleaa hhasavrfsk eyemqktkee dflklfdrwk eeekeklvde
      301 mekvkemfmk efkeltskns aleyqlseiq ksnmqiksni gtlkdahefk edrspypqdf
      361 hnvmqlldsq eskwtarvqa ihqehkkekg rllshieklr tsmiddlnas nvfykkriee
      421 lgqrlqeqne liitqrqqik dftcnplnsi sepkgnplaw qafesqpaap avpmnapalh
      481 tletksslpm vheqafsshi lepieelsee ekgreneqkl nnnkmhlrka lksnssltkg
      541 lrtmveqnlm ekletlgina dirgissdql hrvlksvese rhkqereipn fhqirefleh
      601 qvsckieeka llssdqcsvs qmdtlstgev pkmiqlpskn rqlirqkavs tdrtsvpkik
      661 knvmedpfpr ksstittppf sseeeqeddd lirayaspgp lpvpppqnkg sfgkntvksd
      721 adgtegseie dtddspkpag vavktptekv ekmfphrknv nkpvggtnvp emfikkeelq
      781 elkcadvede dwdissleee islgkksgke qkepppakne phfahvlnaw gafnpkgpkg
      841 eglllspliq arsifllvvf hlykylinlc wyiirqkscq cflyvi
//
LOCUS       XP_047286126             881 aa            linear   PRI 05-AUG-2025
DEFINITION  cilium assembly protein DZIP1 isoform X10 [Homo sapiens].
ACCESSION   XP_047286126
VERSION     XP_047286126.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430170.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..881
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..881
                     /product="cilium assembly protein DZIP1 isoform X10"
                     /calculated_mol_wt=100611
     Region          58..178
                     /region_name="Dzip-like_N"
                     /note="Iguana/Dzip1-like DAZ-interacting protein
                     N-terminal; pfam13815"
                     /db_xref="CDD:433498"
     Region          <144..>440
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          200..221
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..881
                     /gene="DZIP1"
                     /gene_synonym="DZIP; DZIPt1; MMVP3; MVP3; SPGF47"
                     /coded_by="XM_047430170.1:856..3501"
                     /db_xref="GeneID:22873"
                     /db_xref="HGNC:HGNC:20908"
                     /db_xref="MIM:608671"
ORIGIN      
        1 mqaeaadwfs smpfqkhvyy plasgpegpd vavaaaaaga asmacappsa asgplpffqf
       61 rprlesvdwr rlsaidvdkv agavdvltlq enimnitfck ledekcphcq sgvdpvllkl
      121 irlaqftiey llhsqeflts qlhtleerlr lshcdgeqsk klltkqagei ktlkeeckrr
      181 kkmistqqlm ieakanyyqc hfcdkafmnq aflqshiqrr hteenshfey qknaqieklr
      241 seivvlkeel qltrseleaa hhasavrfsk eyemqktkee dflklfdrwk eeekeklvde
      301 mekvkemfmk efkeltskns aleyqlseiq ksnmqiksni gtlkdahefk edrspypqdf
      361 hnvmqlldsq eskwtarvqa ihqehkkekg rllshieklr tsmiddlnas nvfykkriee
      421 lgqrlqeqne liitqrqqik dftcnplnsi sepkgnplaw qafesqpaap avpmnapalh
      481 tletksslpm vheqafsshi lepieelsee ekgreneqkl nnnkmhlrka lksnssltkg
      541 lrtmveqnlm ekletlgina dirgissdql hrvlksvese rhkqereipn fhqirefleh
      601 qvsckieeka llssdqcsvs qmdtlstgev pkmiqlpskn rqlirqkavs tdrtsvpkik
      661 knvmedpfpr ksstitseee qedddliray aspgplpvpp pqnkgsfgkn tvksdadgte
      721 gseiedtdds pkpagvavkt ptekvekmfp hrknvnkpvg gtnvpemfik keelqelkca
      781 dvededwdis sleeeislgk ksgkeqkepp paknephfah vlnawgafnp kgpkgeglll
      841 spliqarsif llvvfhlyky linlcwyiir qkscqcflyv i
//
LOCUS       XP_047286127             881 aa            linear   PRI 05-AUG-2025
DEFINITION  cilium assembly protein DZIP1 isoform X10 [Homo sapiens].
ACCESSION   XP_047286127
VERSION     XP_047286127.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430171.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..881
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..881
                     /product="cilium assembly protein DZIP1 isoform X10"
                     /calculated_mol_wt=100611
     Region          58..178
                     /region_name="Dzip-like_N"
                     /note="Iguana/Dzip1-like DAZ-interacting protein
                     N-terminal; pfam13815"
                     /db_xref="CDD:433498"
     Region          <144..>440
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          200..221
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..881
                     /gene="DZIP1"
                     /gene_synonym="DZIP; DZIPt1; MMVP3; MVP3; SPGF47"
                     /coded_by="XM_047430171.1:1534..4179"
                     /db_xref="GeneID:22873"
                     /db_xref="HGNC:HGNC:20908"
                     /db_xref="MIM:608671"
ORIGIN      
        1 mqaeaadwfs smpfqkhvyy plasgpegpd vavaaaaaga asmacappsa asgplpffqf
       61 rprlesvdwr rlsaidvdkv agavdvltlq enimnitfck ledekcphcq sgvdpvllkl
      121 irlaqftiey llhsqeflts qlhtleerlr lshcdgeqsk klltkqagei ktlkeeckrr
      181 kkmistqqlm ieakanyyqc hfcdkafmnq aflqshiqrr hteenshfey qknaqieklr
      241 seivvlkeel qltrseleaa hhasavrfsk eyemqktkee dflklfdrwk eeekeklvde
      301 mekvkemfmk efkeltskns aleyqlseiq ksnmqiksni gtlkdahefk edrspypqdf
      361 hnvmqlldsq eskwtarvqa ihqehkkekg rllshieklr tsmiddlnas nvfykkriee
      421 lgqrlqeqne liitqrqqik dftcnplnsi sepkgnplaw qafesqpaap avpmnapalh
      481 tletksslpm vheqafsshi lepieelsee ekgreneqkl nnnkmhlrka lksnssltkg
      541 lrtmveqnlm ekletlgina dirgissdql hrvlksvese rhkqereipn fhqirefleh
      601 qvsckieeka llssdqcsvs qmdtlstgev pkmiqlpskn rqlirqkavs tdrtsvpkik
      661 knvmedpfpr ksstitseee qedddliray aspgplpvpp pqnkgsfgkn tvksdadgte
      721 gseiedtdds pkpagvavkt ptekvekmfp hrknvnkpvg gtnvpemfik keelqelkca
      781 dvededwdis sleeeislgk ksgkeqkepp paknephfah vlnawgafnp kgpkgeglll
      841 spliqarsif llvvfhlyky linlcwyiir qkscqcflyv i
//
LOCUS       XP_047286128             867 aa            linear   PRI 05-AUG-2025
DEFINITION  cilium assembly protein DZIP1 isoform X11 [Homo sapiens].
ACCESSION   XP_047286128
VERSION     XP_047286128.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430172.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..867
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..867
                     /product="cilium assembly protein DZIP1 isoform X11"
                     /calculated_mol_wt=98533
     Region          58..178
                     /region_name="Dzip-like_N"
                     /note="Iguana/Dzip1-like DAZ-interacting protein
                     N-terminal; pfam13815"
                     /db_xref="CDD:433498"
     Region          <144..>440
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          198..222
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275369"
     Site            order(198,205,207..209,211..212,216,220)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275369"
     CDS             1..867
                     /gene="DZIP1"
                     /gene_synonym="DZIP; DZIPt1; MMVP3; MVP3; SPGF47"
                     /coded_by="XM_047430172.1:1534..4137"
                     /db_xref="GeneID:22873"
                     /db_xref="HGNC:HGNC:20908"
                     /db_xref="MIM:608671"
ORIGIN      
        1 mqaeaadwfs smpfqkhvyy plasgpegpd vavaaaaaga asmacappsa asgplpffqf
       61 rprlesvdwr rlsaidvdkv agavdvltlq enimnitfck ledekcphcq sgvdpvllkl
      121 irlaqftiey llhsqeflts qlhtleerlr lshcdgeqsk klltkqagei ktlkeeckrr
      181 kkmistqqlm ieakanyyqc hfcdkafmnq aflqshiqrr hteenshfey qknaqieklr
      241 seivvlkeel qltrseleaa hhasavrfsk eyemqktkee dflklfdrwk eeekeklvde
      301 mekvkemfmk efkeltskns aleyqlseiq ksnmqiksni gtlkdahefk edrspypqdf
      361 hnvmqlldsq eskwtarvqa ihqehkkekg rllshieklr tsmiddlnas nvfykkriee
      421 lgqrlqeqne liitqrqqik dftcnplnsi sepkgnplaw qafesqpaap avpmnapalh
      481 tletksslpm vheqafsshi lepieelsee ekgreneqkl nnnkmhlrka lksnssltkg
      541 lrtmveqnlm ekletlgina dirgissdql hrvlksvese rhkqereipn fhqirefleh
      601 qvsckieeka llssdqcsvs qmdtlstgev pkmiqlpskn rqlirqkavs tdrtsvpkik
      661 knvmedpfpr ksstittppf sseeeqeddd lirayaspgp lpvpppqnkg sfgkntvksd
      721 adgtegseie dtddspkpag vavktptekv ekmfphrknv nkpvggtnvp emfikkeelq
      781 elkcadvede dwdissleee islgkksgke qkepppakne phfahvlnaw gafnpkgpkg
      841 eglqenesst lksslvtvtd wsdtsdv
//
LOCUS       XP_047286129             866 aa            linear   PRI 05-AUG-2025
DEFINITION  cilium assembly protein DZIP1 isoform X12 [Homo sapiens].
ACCESSION   XP_047286129
VERSION     XP_047286129.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430173.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..866
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..866
                     /product="cilium assembly protein DZIP1 isoform X12"
                     /calculated_mol_wt=98814
     Region          58..178
                     /region_name="Dzip-like_N"
                     /note="Iguana/Dzip1-like DAZ-interacting protein
                     N-terminal; pfam13815"
                     /db_xref="CDD:433498"
     Region          <144..>440
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          200..221
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..866
                     /gene="DZIP1"
                     /gene_synonym="DZIP; DZIPt1; MMVP3; MVP3; SPGF47"
                     /coded_by="XM_047430173.1:856..3456"
                     /db_xref="GeneID:22873"
                     /db_xref="HGNC:HGNC:20908"
                     /db_xref="MIM:608671"
ORIGIN      
        1 mqaeaadwfs smpfqkhvyy plasgpegpd vavaaaaaga asmacappsa asgplpffqf
       61 rprlesvdwr rlsaidvdkv agavdvltlq enimnitfck ledekcphcq sgvdpvllkl
      121 irlaqftiey llhsqeflts qlhtleerlr lshcdgeqsk klltkqagei ktlkeeckrr
      181 kkmistqqlm ieakanyyqc hfcdkafmnq aflqshiqrr hteenshfey qknaqieklr
      241 seivvlkeel qltrseleaa hhasavrfsk eyemqktkee dflklfdrwk eeekeklvde
      301 mekvkemfmk efkeltskns aleyqlseiq ksnmqiksni gtlkdahefk edrspypqdf
      361 hnvmqlldsq eskwtarvqa ihqehkkekg rllshieklr tsmiddlnas nvfykkriee
      421 lgqrlqeqne liitqrqqik dftcnplnsi sepkgnplaw qafesqpaap avpmnapalh
      481 tletksslpm vhgreneqkl nnnkmhlrka lksnssltkg lrtmveqnlm ekletlgina
      541 dirgissdql hrvlksvese rhkqereipn fhqirefleh qvsckieeka llssdqcsvs
      601 qmdtlstgev pkmiqlpskn rqlirqkavs tdrtsvpkik knvmedpfpr ksstittppf
      661 sseeeqeddd lirayaspgp lpvpppqnkg sfgkntvksd adgtegseie dtddspkpag
      721 vavktptekv ekmfphrknv nkpvggtnvp emfikkeelq elkcadvede dwdissleee
      781 islgkksgke qkepppakne phfahvlnaw gafnpkgpkg eglllspliq arsifllvvf
      841 hlykylinlc wyiirqkscq cflyvi
//
LOCUS       XP_047286130             866 aa            linear   PRI 05-AUG-2025
DEFINITION  cilium assembly protein DZIP1 isoform X12 [Homo sapiens].
ACCESSION   XP_047286130
VERSION     XP_047286130.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430174.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..866
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..866
                     /product="cilium assembly protein DZIP1 isoform X12"
                     /calculated_mol_wt=98814
     Region          58..178
                     /region_name="Dzip-like_N"
                     /note="Iguana/Dzip1-like DAZ-interacting protein
                     N-terminal; pfam13815"
                     /db_xref="CDD:433498"
     Region          <144..>440
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          200..221
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..866
                     /gene="DZIP1"
                     /gene_synonym="DZIP; DZIPt1; MMVP3; MVP3; SPGF47"
                     /coded_by="XM_047430174.1:1534..4134"
                     /db_xref="GeneID:22873"
                     /db_xref="HGNC:HGNC:20908"
                     /db_xref="MIM:608671"
ORIGIN      
        1 mqaeaadwfs smpfqkhvyy plasgpegpd vavaaaaaga asmacappsa asgplpffqf
       61 rprlesvdwr rlsaidvdkv agavdvltlq enimnitfck ledekcphcq sgvdpvllkl
      121 irlaqftiey llhsqeflts qlhtleerlr lshcdgeqsk klltkqagei ktlkeeckrr
      181 kkmistqqlm ieakanyyqc hfcdkafmnq aflqshiqrr hteenshfey qknaqieklr
      241 seivvlkeel qltrseleaa hhasavrfsk eyemqktkee dflklfdrwk eeekeklvde
      301 mekvkemfmk efkeltskns aleyqlseiq ksnmqiksni gtlkdahefk edrspypqdf
      361 hnvmqlldsq eskwtarvqa ihqehkkekg rllshieklr tsmiddlnas nvfykkriee
      421 lgqrlqeqne liitqrqqik dftcnplnsi sepkgnplaw qafesqpaap avpmnapalh
      481 tletksslpm vhgreneqkl nnnkmhlrka lksnssltkg lrtmveqnlm ekletlgina
      541 dirgissdql hrvlksvese rhkqereipn fhqirefleh qvsckieeka llssdqcsvs
      601 qmdtlstgev pkmiqlpskn rqlirqkavs tdrtsvpkik knvmedpfpr ksstittppf
      661 sseeeqeddd lirayaspgp lpvpppqnkg sfgkntvksd adgtegseie dtddspkpag
      721 vavktptekv ekmfphrknv nkpvggtnvp emfikkeelq elkcadvede dwdissleee
      781 islgkksgke qkepppakne phfahvlnaw gafnpkgpkg eglllspliq arsifllvvf
      841 hlykylinlc wyiirqkscq cflyvi
//
LOCUS       XP_047286131             862 aa            linear   PRI 05-AUG-2025
DEFINITION  cilium assembly protein DZIP1 isoform X13 [Homo sapiens].
ACCESSION   XP_047286131
VERSION     XP_047286131.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430175.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..862
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..862
                     /product="cilium assembly protein DZIP1 isoform X13"
                     /calculated_mol_wt=98003
     Region          58..178
                     /region_name="Dzip-like_N"
                     /note="Iguana/Dzip1-like DAZ-interacting protein
                     N-terminal; pfam13815"
                     /db_xref="CDD:433498"
     Region          <144..>440
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          198..222
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275369"
     Site            order(198,205,207..209,211..212,216,220)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275369"
     CDS             1..862
                     /gene="DZIP1"
                     /gene_synonym="DZIP; DZIPt1; MMVP3; MVP3; SPGF47"
                     /coded_by="XM_047430175.1:856..3444"
                     /db_xref="GeneID:22873"
                     /db_xref="HGNC:HGNC:20908"
                     /db_xref="MIM:608671"
ORIGIN      
        1 mqaeaadwfs smpfqkhvyy plasgpegpd vavaaaaaga asmacappsa asgplpffqf
       61 rprlesvdwr rlsaidvdkv agavdvltlq enimnitfck ledekcphcq sgvdpvllkl
      121 irlaqftiey llhsqeflts qlhtleerlr lshcdgeqsk klltkqagei ktlkeeckrr
      181 kkmistqqlm ieakanyyqc hfcdkafmnq aflqshiqrr hteenshfey qknaqieklr
      241 seivvlkeel qltrseleaa hhasavrfsk eyemqktkee dflklfdrwk eeekeklvde
      301 mekvkemfmk efkeltskns aleyqlseiq ksnmqiksni gtlkdahefk edrspypqdf
      361 hnvmqlldsq eskwtarvqa ihqehkkekg rllshieklr tsmiddlnas nvfykkriee
      421 lgqrlqeqne liitqrqqik dftcnplnsi sepkgnplaw qafesqpaap avpmnapalh
      481 tletksslpm vheqafsshi lepieelsee ekgreneqkl nnnkmhlrka lksnssltkg
      541 lrtmveqnlm ekletlgina dirgissdql hrvlksvese rhkqereipn fhqirefleh
      601 qvsckieeka llssdqcsvs qmdtlstgev pkmiqlpskn rqlirqkavs tdrtsvpkik
      661 knvmedpfpr ksstitseee qedddliray aspgplpvpp pqnkgsfgkn tvksdadgte
      721 gseiedtdds pkpagvavkt ptekvekmfp hrknvnkpvg gtnvpemfik keelqelkca
      781 dvededwdis sleeeislgk ksgkeqkepp paknephfah vlnawgafnp kgpkgeglqe
      841 nesstlkssl vtvtdwsdts dv
//
LOCUS       XP_047286132             862 aa            linear   PRI 05-AUG-2025
DEFINITION  cilium assembly protein DZIP1 isoform X13 [Homo sapiens].
ACCESSION   XP_047286132
VERSION     XP_047286132.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430176.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..862
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..862
                     /product="cilium assembly protein DZIP1 isoform X13"
                     /calculated_mol_wt=98003
     Region          58..178
                     /region_name="Dzip-like_N"
                     /note="Iguana/Dzip1-like DAZ-interacting protein
                     N-terminal; pfam13815"
                     /db_xref="CDD:433498"
     Region          <144..>440
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          198..222
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275369"
     Site            order(198,205,207..209,211..212,216,220)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275369"
     CDS             1..862
                     /gene="DZIP1"
                     /gene_synonym="DZIP; DZIPt1; MMVP3; MVP3; SPGF47"
                     /coded_by="XM_047430176.1:1534..4122"
                     /db_xref="GeneID:22873"
                     /db_xref="HGNC:HGNC:20908"
                     /db_xref="MIM:608671"
ORIGIN      
        1 mqaeaadwfs smpfqkhvyy plasgpegpd vavaaaaaga asmacappsa asgplpffqf
       61 rprlesvdwr rlsaidvdkv agavdvltlq enimnitfck ledekcphcq sgvdpvllkl
      121 irlaqftiey llhsqeflts qlhtleerlr lshcdgeqsk klltkqagei ktlkeeckrr
      181 kkmistqqlm ieakanyyqc hfcdkafmnq aflqshiqrr hteenshfey qknaqieklr
      241 seivvlkeel qltrseleaa hhasavrfsk eyemqktkee dflklfdrwk eeekeklvde
      301 mekvkemfmk efkeltskns aleyqlseiq ksnmqiksni gtlkdahefk edrspypqdf
      361 hnvmqlldsq eskwtarvqa ihqehkkekg rllshieklr tsmiddlnas nvfykkriee
      421 lgqrlqeqne liitqrqqik dftcnplnsi sepkgnplaw qafesqpaap avpmnapalh
      481 tletksslpm vheqafsshi lepieelsee ekgreneqkl nnnkmhlrka lksnssltkg
      541 lrtmveqnlm ekletlgina dirgissdql hrvlksvese rhkqereipn fhqirefleh
      601 qvsckieeka llssdqcsvs qmdtlstgev pkmiqlpskn rqlirqkavs tdrtsvpkik
      661 knvmedpfpr ksstitseee qedddliray aspgplpvpp pqnkgsfgkn tvksdadgte
      721 gseiedtdds pkpagvavkt ptekvekmfp hrknvnkpvg gtnvpemfik keelqelkca
      781 dvededwdis sleeeislgk ksgkeqkepp paknephfah vlnawgafnp kgpkgeglqe
      841 nesstlkssl vtvtdwsdts dv
//
LOCUS       XP_047286133             861 aa            linear   PRI 05-AUG-2025
DEFINITION  cilium assembly protein DZIP1 isoform X14 [Homo sapiens].
ACCESSION   XP_047286133
VERSION     XP_047286133.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430177.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..861
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..861
                     /product="cilium assembly protein DZIP1 isoform X14"
                     /calculated_mol_wt=98285
     Region          58..178
                     /region_name="Dzip-like_N"
                     /note="Iguana/Dzip1-like DAZ-interacting protein
                     N-terminal; pfam13815"
                     /db_xref="CDD:433498"
     Region          <144..>440
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          200..221
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..861
                     /gene="DZIP1"
                     /gene_synonym="DZIP; DZIPt1; MMVP3; MVP3; SPGF47"
                     /coded_by="XM_047430177.1:856..3441"
                     /db_xref="GeneID:22873"
                     /db_xref="HGNC:HGNC:20908"
                     /db_xref="MIM:608671"
ORIGIN      
        1 mqaeaadwfs smpfqkhvyy plasgpegpd vavaaaaaga asmacappsa asgplpffqf
       61 rprlesvdwr rlsaidvdkv agavdvltlq enimnitfck ledekcphcq sgvdpvllkl
      121 irlaqftiey llhsqeflts qlhtleerlr lshcdgeqsk klltkqagei ktlkeeckrr
      181 kkmistqqlm ieakanyyqc hfcdkafmnq aflqshiqrr hteenshfey qknaqieklr
      241 seivvlkeel qltrseleaa hhasavrfsk eyemqktkee dflklfdrwk eeekeklvde
      301 mekvkemfmk efkeltskns aleyqlseiq ksnmqiksni gtlkdahefk edrspypqdf
      361 hnvmqlldsq eskwtarvqa ihqehkkekg rllshieklr tsmiddlnas nvfykkriee
      421 lgqrlqeqne liitqrqqik dftcnplnsi sepkgnplaw qafesqpaap avpmnapalh
      481 tletksslpm vhgreneqkl nnnkmhlrka lksnssltkg lrtmveqnlm ekletlgina
      541 dirgissdql hrvlksvese rhkqereipn fhqirefleh qvsckieeka llssdqcsvs
      601 qmdtlstgev pkmiqlpskn rqlirqkavs tdrtsvpkik knvmedpfpr ksstitseee
      661 qedddliray aspgplpvpp pqnkgsfgkn tvksdadgte gseiedtdds pkpagvavkt
      721 ptekvekmfp hrknvnkpvg gtnvpemfik keelqelkca dvededwdis sleeeislgk
      781 ksgkeqkepp paknephfah vlnawgafnp kgpkgeglll spliqarsif llvvfhlyky
      841 linlcwyiir qkscqcflyv i
//
LOCUS       XP_047286134             847 aa            linear   PRI 05-AUG-2025
DEFINITION  cilium assembly protein DZIP1 isoform X15 [Homo sapiens].
ACCESSION   XP_047286134
VERSION     XP_047286134.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430178.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..847
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..847
                     /product="cilium assembly protein DZIP1 isoform X15"
                     /calculated_mol_wt=96207
     Region          58..178
                     /region_name="Dzip-like_N"
                     /note="Iguana/Dzip1-like DAZ-interacting protein
                     N-terminal; pfam13815"
                     /db_xref="CDD:433498"
     Region          <144..>440
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          198..222
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275369"
     Site            order(198,205,207..209,211..212,216,220)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275369"
     CDS             1..847
                     /gene="DZIP1"
                     /gene_synonym="DZIP; DZIPt1; MMVP3; MVP3; SPGF47"
                     /coded_by="XM_047430178.1:856..3399"
                     /db_xref="GeneID:22873"
                     /db_xref="HGNC:HGNC:20908"
                     /db_xref="MIM:608671"
ORIGIN      
        1 mqaeaadwfs smpfqkhvyy plasgpegpd vavaaaaaga asmacappsa asgplpffqf
       61 rprlesvdwr rlsaidvdkv agavdvltlq enimnitfck ledekcphcq sgvdpvllkl
      121 irlaqftiey llhsqeflts qlhtleerlr lshcdgeqsk klltkqagei ktlkeeckrr
      181 kkmistqqlm ieakanyyqc hfcdkafmnq aflqshiqrr hteenshfey qknaqieklr
      241 seivvlkeel qltrseleaa hhasavrfsk eyemqktkee dflklfdrwk eeekeklvde
      301 mekvkemfmk efkeltskns aleyqlseiq ksnmqiksni gtlkdahefk edrspypqdf
      361 hnvmqlldsq eskwtarvqa ihqehkkekg rllshieklr tsmiddlnas nvfykkriee
      421 lgqrlqeqne liitqrqqik dftcnplnsi sepkgnplaw qafesqpaap avpmnapalh
      481 tletksslpm vhgreneqkl nnnkmhlrka lksnssltkg lrtmveqnlm ekletlgina
      541 dirgissdql hrvlksvese rhkqereipn fhqirefleh qvsckieeka llssdqcsvs
      601 qmdtlstgev pkmiqlpskn rqlirqkavs tdrtsvpkik knvmedpfpr ksstittppf
      661 sseeeqeddd lirayaspgp lpvpppqnkg sfgkntvksd adgtegseie dtddspkpag
      721 vavktptekv ekmfphrknv nkpvggtnvp emfikkeelq elkcadvede dwdissleee
      781 islgkksgke qkepppakne phfahvlnaw gafnpkgpkg eglqenesst lksslvtvtd
      841 wsdtsdv
//
LOCUS       XP_047286135             847 aa            linear   PRI 05-AUG-2025
DEFINITION  cilium assembly protein DZIP1 isoform X15 [Homo sapiens].
ACCESSION   XP_047286135
VERSION     XP_047286135.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430179.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..847
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..847
                     /product="cilium assembly protein DZIP1 isoform X15"
                     /calculated_mol_wt=96207
     Region          58..178
                     /region_name="Dzip-like_N"
                     /note="Iguana/Dzip1-like DAZ-interacting protein
                     N-terminal; pfam13815"
                     /db_xref="CDD:433498"
     Region          <144..>440
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          198..222
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275369"
     Site            order(198,205,207..209,211..212,216,220)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275369"
     CDS             1..847
                     /gene="DZIP1"
                     /gene_synonym="DZIP; DZIPt1; MMVP3; MVP3; SPGF47"
                     /coded_by="XM_047430179.1:1534..4077"
                     /db_xref="GeneID:22873"
                     /db_xref="HGNC:HGNC:20908"
                     /db_xref="MIM:608671"
ORIGIN      
        1 mqaeaadwfs smpfqkhvyy plasgpegpd vavaaaaaga asmacappsa asgplpffqf
       61 rprlesvdwr rlsaidvdkv agavdvltlq enimnitfck ledekcphcq sgvdpvllkl
      121 irlaqftiey llhsqeflts qlhtleerlr lshcdgeqsk klltkqagei ktlkeeckrr
      181 kkmistqqlm ieakanyyqc hfcdkafmnq aflqshiqrr hteenshfey qknaqieklr
      241 seivvlkeel qltrseleaa hhasavrfsk eyemqktkee dflklfdrwk eeekeklvde
      301 mekvkemfmk efkeltskns aleyqlseiq ksnmqiksni gtlkdahefk edrspypqdf
      361 hnvmqlldsq eskwtarvqa ihqehkkekg rllshieklr tsmiddlnas nvfykkriee
      421 lgqrlqeqne liitqrqqik dftcnplnsi sepkgnplaw qafesqpaap avpmnapalh
      481 tletksslpm vhgreneqkl nnnkmhlrka lksnssltkg lrtmveqnlm ekletlgina
      541 dirgissdql hrvlksvese rhkqereipn fhqirefleh qvsckieeka llssdqcsvs
      601 qmdtlstgev pkmiqlpskn rqlirqkavs tdrtsvpkik knvmedpfpr ksstittppf
      661 sseeeqeddd lirayaspgp lpvpppqnkg sfgkntvksd adgtegseie dtddspkpag
      721 vavktptekv ekmfphrknv nkpvggtnvp emfikkeelq elkcadvede dwdissleee
      781 islgkksgke qkepppakne phfahvlnaw gafnpkgpkg eglqenesst lksslvtvtd
      841 wsdtsdv
//
LOCUS       XP_047286136             842 aa            linear   PRI 05-AUG-2025
DEFINITION  cilium assembly protein DZIP1 isoform X16 [Homo sapiens].
ACCESSION   XP_047286136
VERSION     XP_047286136.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430180.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..842
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..842
                     /product="cilium assembly protein DZIP1 isoform X16"
                     /calculated_mol_wt=95677
     Region          58..178
                     /region_name="Dzip-like_N"
                     /note="Iguana/Dzip1-like DAZ-interacting protein
                     N-terminal; pfam13815"
                     /db_xref="CDD:433498"
     Region          <144..>440
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          198..222
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275369"
     Site            order(198,205,207..209,211..212,216,220)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275369"
     CDS             1..842
                     /gene="DZIP1"
                     /gene_synonym="DZIP; DZIPt1; MMVP3; MVP3; SPGF47"
                     /coded_by="XM_047430180.1:856..3384"
                     /db_xref="GeneID:22873"
                     /db_xref="HGNC:HGNC:20908"
                     /db_xref="MIM:608671"
ORIGIN      
        1 mqaeaadwfs smpfqkhvyy plasgpegpd vavaaaaaga asmacappsa asgplpffqf
       61 rprlesvdwr rlsaidvdkv agavdvltlq enimnitfck ledekcphcq sgvdpvllkl
      121 irlaqftiey llhsqeflts qlhtleerlr lshcdgeqsk klltkqagei ktlkeeckrr
      181 kkmistqqlm ieakanyyqc hfcdkafmnq aflqshiqrr hteenshfey qknaqieklr
      241 seivvlkeel qltrseleaa hhasavrfsk eyemqktkee dflklfdrwk eeekeklvde
      301 mekvkemfmk efkeltskns aleyqlseiq ksnmqiksni gtlkdahefk edrspypqdf
      361 hnvmqlldsq eskwtarvqa ihqehkkekg rllshieklr tsmiddlnas nvfykkriee
      421 lgqrlqeqne liitqrqqik dftcnplnsi sepkgnplaw qafesqpaap avpmnapalh
      481 tletksslpm vhgreneqkl nnnkmhlrka lksnssltkg lrtmveqnlm ekletlgina
      541 dirgissdql hrvlksvese rhkqereipn fhqirefleh qvsckieeka llssdqcsvs
      601 qmdtlstgev pkmiqlpskn rqlirqkavs tdrtsvpkik knvmedpfpr ksstitseee
      661 qedddliray aspgplpvpp pqnkgsfgkn tvksdadgte gseiedtdds pkpagvavkt
      721 ptekvekmfp hrknvnkpvg gtnvpemfik keelqelkca dvededwdis sleeeislgk
      781 ksgkeqkepp paknephfah vlnawgafnp kgpkgeglqe nesstlkssl vtvtdwsdts
      841 dv
//
LOCUS       XP_047286137             613 aa            linear   PRI 05-AUG-2025
DEFINITION  cilium assembly protein DZIP1 isoform X17 [Homo sapiens].
ACCESSION   XP_047286137
VERSION     XP_047286137.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430181.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..613
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..613
                     /product="cilium assembly protein DZIP1 isoform X17"
                     /calculated_mol_wt=70100
     CDS             1..613
                     /gene="DZIP1"
                     /gene_synonym="DZIP; DZIPt1; MMVP3; MVP3; SPGF47"
                     /coded_by="XM_047430181.1:229..2070"
                     /db_xref="GeneID:22873"
                     /db_xref="HGNC:HGNC:20908"
                     /db_xref="MIM:608671"
ORIGIN      
        1 mqktkeedfl klfdrwkeee keklvdemek vkemfmkefk eltsknsale yqlseiqksn
       61 mqiksnigtl kdahefkedr spypqdfhnv mqlldsqesk wtarvqaihq ehkkekgrll
      121 shieklrtsm iddlnasnvf ykkrieelgq rlqeqnelii tqrqqikdft cnplnsisep
      181 kgnplawqaf esqpaapavp mnapalhtle tksslpmvhe qafsshilep ieelseeekg
      241 reneqklnnn kmhlrkalks nssltkglrt mveqnlmekl etlginadir gissdqlhrv
      301 lksveserhk qereipnfhq ireflehqvs ckieekalls sdqcsvsqmd tlstgevpkm
      361 iqlpsknrql irqkavstdr tsvpkikknv medpfprkss tittppfsse eeqedddlir
      421 ayaspgplpv pppqnkgsfg kntvksdadg tegseiedtd dspkpagvav ktptekvekm
      481 fphrknvnkp vggtnvpemf ikkeelqelk cadvededwd issleeeisl gkksgkeqke
      541 pppaknephf ahvlnawgaf npkgpkgegl llspliqars ifllvvfhly kylinlcwyi
      601 irqkscqcfl yvi
//
LOCUS       XP_047286138            1879 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-XVI isoform X1 [Homo sapiens].
ACCESSION   XP_047286138
VERSION     XP_047286138.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430182.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1879
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1879
                     /product="unconventional myosin-XVI isoform X1"
                     /calculated_mol_wt=208627
     Region          67..347
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          86..112
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(114,116,120..121,124..126,128..129,133,136,145,147,
                     149,153..154,157..159,161..162,166,169,178,180,182,
                     186..187,190,193..194,196..197,201,204)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          114..145
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          147..178
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          180..210
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          243..274
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          276..307
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          309..335
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          436..1154
                     /region_name="MYSc_Myo16"
                     /note="class XVI myosin, motor domain; cd14878"
                     /db_xref="CDD:276844"
     Site            order(463..471,518..525,563..573,799..804)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276844"
     Site            463..471
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276844"
     Site            518..525
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276844"
     Site            563..573
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276844"
     Site            799..804
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276844"
     Site            828..851
                     /site_type="other"
                     /note="relay loop"
                     /db_xref="CDD:276844"
     Site            1087..1096
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276844"
     Site            order(1099..1117,1122..1154)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276844"
     Region          1242..1589
                     /region_name="NYAP_N"
                     /note="Neuronal tyrosine-phosphorylated
                     phosphoinositide-3-kinase adapter; pfam15439"
                     /db_xref="CDD:464717"
     Region          1651..1879
                     /region_name="NYAP_C"
                     /note="Neuronal tyrosine-phosphorylated
                     phosphoinositide-3-kinase adapter; pfam15452"
                     /db_xref="CDD:464724"
     CDS             1..1879
                     /gene="MYO16"
                     /gene_synonym="MYAP3; Myo16b; MYR8; NYAP3; PPP1R107"
                     /coded_by="XM_047430182.1:235..5874"
                     /db_xref="GeneID:23026"
                     /db_xref="HGNC:HGNC:29822"
                     /db_xref="MIM:615479"
ORIGIN      
        1 mshyhfikcc cfqlcnvfrs hemeidqcll eslplgqrqr lvkrmrceqi kayyerekaf
       61 qkqegflkrl khaknpkvhf nltdmlqdai ihhndkevlr llkegadpht lvssggsllh
      121 lcarydnafi aeilidrgvn vnhqdedfwt pmhiacacdn pdivlllvla ganvllqdvn
      181 gnipldyave gtesssillt yldengvdlt slrqmklqrp msmltdvkhf lssggnvnek
      241 ndegvtllhm acasgykevv slilehggdl nivddqywtp lhlaakygqt nlvklllmhq
      301 anphlvncne ekasdiaase fieemllkae iaweekmkep lsastlaqee pyeeiihdlp
      361 vlssklplvl piakqdslle kdimfkdatk glckqqsqds ipenpmmsgs tkpeqvklmp
      421 papnddlatl selndgslly eiqkrfgnnq iytfigdill lvnpykelpi yssmvsqlyf
      481 sssgklcssl pphlfscver afhqlfreqr pqcfilsger gsgkseaskq iirhltcrag
      541 asratldsrf khvvcileaf ghakttlndl sscfikyfel qfcerkqqlt gariytylle
      601 ksrlvsqplg qsnflifyll mdglsaeeky glhlnnlcah rylnqtiqdd astgerslnr
      661 eklavlkral nvvgfsslev enlfvilaai lhlgdirfta lnegnsafvs dlqlleqvag
      721 mlqvstdela salttdiqyf kgdmiirrht iqiaeffrdl lakslysrlf sflvntmnsc
      781 lhsqdeqksm qtldigildi fgfeefqkne feqlcvnmtn ekmhhyinev lflheqvecv
      841 qegvtmetay spgnqngvld fffqkpsgfl tlldeesqmi wsvesnfpkk lqsllessnt
      901 navyspmkdg ngnvalkdhg taftimhyag rvmydvvgai eknkdslsqn llfvmktsen
      961 vvinhlfqsk lsqtgslvsa ypsfkfrghk sallskkmta ssiigenkny lelskllkkk
     1021 gtstflqrle rgdpvtiasq lrkslmdiig klqkctphfi hcirpnnskl pdtfdnfyvs
     1081 aqlqyigvle mvkifrygyp vrlsfsdfls rykpladtfl rekkeqsaae rcrlvlqqck
     1141 lqgwqmgvrk vflkywhadq lndlclqlqr kiitcqkvir gflarqhllq risirqqevt
     1201 sinsflqnte dmglktydal viqnasdiar endrlrsemn apyhkeklev rnmqeegskr
     1261 tddksgprhf hpssmsvcaa vdglgqclvg psiwspslhs vfsmddsssl psprkqpppk
     1321 pkrdpntrls asyeavsacl saareaanea larprphsdd ystmkkippr kpkrspntkl
     1381 sgsyeeisgs rpgdarpaga pgaaarvltp gtpqcalppa appgdeddse pvyiemlgha
     1441 arpdspdpge svyeemkccl pddggpgags fllhgasppl lhrapedeaa gppgdacdip
     1501 ppfpnllphr ppllvfpptp vtcspasdes pltplevkkl pvletnlkyp vqpegsspls
     1561 pqysksqkgd gdrpaspgla lfngsgrasp pstppppppp pgpppapyrp cahlafppep
     1621 apvnagkagp saeapkvhpk pnsapvagpc ssfpkipysp vkatradark agssasppap
     1681 ysppssrpls spldelaslf nsgrsvlrks aagrkireae gfetnmniss rddpstseit
     1741 setqdrnann hgiqlsnsls saitaengns isnglpeedg ysrlsisgtg tstfqrhrds
     1801 httqvihqlr lsenesvalq elldwrrklc eegqdwqqil hhaeprvppp ppckkpsllk
     1861 kpegascnrl pselwdtti
//
LOCUS       XP_011519364            1858 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-XVI isoform X2 [Homo sapiens].
ACCESSION   XP_011519364
VERSION     XP_011519364.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521062.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1858
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1858
                     /product="unconventional myosin-XVI isoform X2"
                     /calculated_mol_wt=205999
     Region          45..325
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          64..90
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(92,94,98..99,102..104,106..107,111,114,123,125,127,
                     131..132,135..137,139..140,144,147,156,158,160,164..165,
                     168,171..172,174..175,179,182)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          92..123
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          125..156
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          158..188
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          221..252
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          254..285
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          287..313
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          415..1133
                     /region_name="MYSc_Myo16"
                     /note="class XVI myosin, motor domain; cd14878"
                     /db_xref="CDD:276844"
     Site            order(442..450,497..504,542..552,778..783)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276844"
     Site            442..450
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276844"
     Site            497..504
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276844"
     Site            542..552
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276844"
     Site            778..783
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276844"
     Site            807..830
                     /site_type="other"
                     /note="relay loop"
                     /db_xref="CDD:276844"
     Site            1066..1075
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276844"
     Site            order(1078..1096,1101..1133)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276844"
     Region          1221..1568
                     /region_name="NYAP_N"
                     /note="Neuronal tyrosine-phosphorylated
                     phosphoinositide-3-kinase adapter; pfam15439"
                     /db_xref="CDD:464717"
     Region          1630..1858
                     /region_name="NYAP_C"
                     /note="Neuronal tyrosine-phosphorylated
                     phosphoinositide-3-kinase adapter; pfam15452"
                     /db_xref="CDD:464724"
     CDS             1..1858
                     /gene="MYO16"
                     /gene_synonym="MYAP3; Myo16b; MYR8; NYAP3; PPP1R107"
                     /coded_by="XM_011521062.2:248..5824"
                     /db_xref="GeneID:23026"
                     /db_xref="HGNC:HGNC:29822"
                     /db_xref="MIM:615479"
ORIGIN      
        1 meidqclles lplgqrqrlv krmrceqika yyerekafqk qegflkrlkh aknpkvhfnl
       61 tdmlqdaiih hndkevlrll kegadphtlv ssggsllhlc arydnafiae ilidrgvnvn
      121 hqdedfwtpm hiacacdnpd ivlllvlaga nvllqdvngn ipldyavegt esssilltyl
      181 dengvdltsl rqmklqrpms mltdvkhfls sggnvneknd egvtllhmac asgykevvsl
      241 ilehggdlni vddqywtplh laakygqtnl vklllmhqan phlvncneek asdiaasefi
      301 eemllkaeia weekmkepls astlaqeepy eeiihdlpvl ssklsplvlp iakqdsllek
      361 dimfkdatkg lckqqsqdsi penpmmsgst kpeqvklmpp apnddlatls elndgsllye
      421 iqkrfgnnqi ytfigdilll vnpykelpiy ssmvsqlyfs ssgklcsslp phlfscvera
      481 fhqlfreqrp qcfilsgerg sgkseaskqi irhltcraga sratldsrfk hvvcileafg
      541 hakttlndls scfikyfelq fcerkqqltg ariytyllek srlvsqplgq snflifyllm
      601 dglsaeekyg lhlnnlcahr ylnqtiqdda stgerslnre klavlkraln vvgfssleve
      661 nlfvilaail hlgdirftal negnsafvsd lqlleqvagm lqvstdelas alttdiqyfk
      721 gdmiirrhti qiaeffrdll akslysrlfs flvntmnscl hsqdeqksmq tldigildif
      781 gfeefqknef eqlcvnmtne kmhhyinevl flheqvecvq egvtmetays pgnqngvldf
      841 ffqkpsgflt lldeesqmiw svesnfpkkl qsllessntn avyspmkdgn gnvalkdhgt
      901 aftimhyagr vmydvvgaie knkdslsqnl lfvmktsenv vinhlfqskl sqtgslvsay
      961 psfkfrghks allskkmtas siigenknyl elskllkkkg tstflqrler gdpvtiasql
     1021 rkslmdiigk lqkctphfih cirpnnsklp dtfdnfyvsa qlqyigvlem vkifrygypv
     1081 rlsfsdflsr ykpladtflr ekkeqsaaer crlvlqqckl qgwqmgvrkv flkywhadql
     1141 ndlclqlqrk iitcqkvirg flarqhllqr isirqqevts insflqnted mglktydalv
     1201 iqnasdiare ndrlrsemna pyhkeklevr nmqeegskrt ddksgprhfh pssmsvcaav
     1261 dglgqclvgp siwspslhsv fsmddssslp sprkqpppkp krdpntrlsa syeavsacls
     1321 aareaaneal arprphsddy stmkkipprk pkrspntkls gsyeeisgsr pgdarpagap
     1381 gaaarvltpg tpqcalppaa ppgdeddsep vyiemlghaa rpdspdpges vyeemkcclp
     1441 ddggpgagsf llhgasppll hrapedeaag ppgdacdipp pfpnllphrp pllvfpptpv
     1501 tcspasdesp ltplevkklp vletnlkypv qpegssplsp qysksqkgdg drpaspglal
     1561 fngsgraspp stpppppppp gpppapyrpc ahlafppepa pvnagkagps aeapkvhpkp
     1621 nsapvagpcs sfpkipyspv katradarka gssasppapy sppssrplss pldelaslfn
     1681 sgrsvlrksa agrkireaeg fetnmnissr ddpstseits etqdrnannh giqlsnslss
     1741 aitaengnsi snglpeedgy srlsisgtgt stfqrhrdsh ttqvihqlrl senesvalqe
     1801 lldwrrklce egqdwqqilh haeprvpppp pckkpsllkk pegascnrlp selwdtti
//
LOCUS       XP_047286139            1857 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-XVI isoform X3 [Homo sapiens].
ACCESSION   XP_047286139
VERSION     XP_047286139.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430183.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1857
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1857
                     /product="unconventional myosin-XVI isoform X3"
                     /calculated_mol_wt=205912
     Region          45..325
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          64..90
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(92,94,98..99,102..104,106..107,111,114,123,125,127,
                     131..132,135..137,139..140,144,147,156,158,160,164..165,
                     168,171..172,174..175,179,182)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          92..123
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          125..156
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          158..188
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          221..252
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          254..285
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          287..313
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          414..1132
                     /region_name="MYSc_Myo16"
                     /note="class XVI myosin, motor domain; cd14878"
                     /db_xref="CDD:276844"
     Site            order(441..449,496..503,541..551,777..782)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276844"
     Site            441..449
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276844"
     Site            496..503
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276844"
     Site            541..551
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276844"
     Site            777..782
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276844"
     Site            806..829
                     /site_type="other"
                     /note="relay loop"
                     /db_xref="CDD:276844"
     Site            1065..1074
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276844"
     Site            order(1077..1095,1100..1132)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276844"
     Region          1220..1567
                     /region_name="NYAP_N"
                     /note="Neuronal tyrosine-phosphorylated
                     phosphoinositide-3-kinase adapter; pfam15439"
                     /db_xref="CDD:464717"
     Region          1629..1857
                     /region_name="NYAP_C"
                     /note="Neuronal tyrosine-phosphorylated
                     phosphoinositide-3-kinase adapter; pfam15452"
                     /db_xref="CDD:464724"
     CDS             1..1857
                     /gene="MYO16"
                     /gene_synonym="MYAP3; Myo16b; MYR8; NYAP3; PPP1R107"
                     /coded_by="XM_047430183.1:248..5821"
                     /db_xref="GeneID:23026"
                     /db_xref="HGNC:HGNC:29822"
                     /db_xref="MIM:615479"
ORIGIN      
        1 meidqclles lplgqrqrlv krmrceqika yyerekafqk qegflkrlkh aknpkvhfnl
       61 tdmlqdaiih hndkevlrll kegadphtlv ssggsllhlc arydnafiae ilidrgvnvn
      121 hqdedfwtpm hiacacdnpd ivlllvlaga nvllqdvngn ipldyavegt esssilltyl
      181 dengvdltsl rqmklqrpms mltdvkhfls sggnvneknd egvtllhmac asgykevvsl
      241 ilehggdlni vddqywtplh laakygqtnl vklllmhqan phlvncneek asdiaasefi
      301 eemllkaeia weekmkepls astlaqeepy eeiihdlpvl ssklplvlpi akqdsllekd
      361 imfkdatkgl ckqqsqdsip enpmmsgstk peqvklmppa pnddlatlse lndgsllyei
      421 qkrfgnnqiy tfigdilllv npykelpiys smvsqlyfss sgklcsslpp hlfscveraf
      481 hqlfreqrpq cfilsgergs gkseaskqii rhltcragas ratldsrfkh vvcileafgh
      541 akttlndlss cfikyfelqf cerkqqltga riytylleks rlvsqplgqs nflifyllmd
      601 glsaeekygl hlnnlcahry lnqtiqddas tgerslnrek lavlkralnv vgfssleven
      661 lfvilaailh lgdirftaln egnsafvsdl qlleqvagml qvstdelasa lttdiqyfkg
      721 dmiirrhtiq iaeffrdlla kslysrlfsf lvntmnsclh sqdeqksmqt ldigildifg
      781 feefqknefe qlcvnmtnek mhhyinevlf lheqvecvqe gvtmetaysp gnqngvldff
      841 fqkpsgfltl ldeesqmiws vesnfpkklq sllessntna vyspmkdgng nvalkdhgta
      901 ftimhyagrv mydvvgaiek nkdslsqnll fvmktsenvv inhlfqskls qtgslvsayp
      961 sfkfrghksa llskkmtass iigenknyle lskllkkkgt stflqrlerg dpvtiasqlr
     1021 kslmdiigkl qkctphfihc irpnnsklpd tfdnfyvsaq lqyigvlemv kifrygypvr
     1081 lsfsdflsry kpladtflre kkeqsaaerc rlvlqqcklq gwqmgvrkvf lkywhadqln
     1141 dlclqlqrki itcqkvirgf larqhllqri sirqqevtsi nsflqntedm glktydalvi
     1201 qnasdiaren drlrsemnap yhkeklevrn mqeegskrtd dksgprhfhp ssmsvcaavd
     1261 glgqclvgps iwspslhsvf smddssslps prkqpppkpk rdpntrlsas yeavsaclsa
     1321 areaaneala rprphsddys tmkkipprkp krspntklsg syeeisgsrp gdarpagapg
     1381 aaarvltpgt pqcalppaap pgdeddsepv yiemlghaar pdspdpgesv yeemkcclpd
     1441 dggpgagsfl lhgasppllh rapedeaagp pgdacdippp fpnllphrpp llvfpptpvt
     1501 cspasdespl tplevkklpv letnlkypvq pegssplspq ysksqkgdgd rpaspglalf
     1561 ngsgraspps tppppppppg pppapyrpca hlafppepap vnagkagpsa eapkvhpkpn
     1621 sapvagpcss fpkipyspvk atradarkag ssasppapys ppssrplssp ldelaslfns
     1681 grsvlrksaa grkireaegf etnmnissrd dpstseitse tqdrnannhg iqlsnslssa
     1741 itaengnsis nglpeedgys rlsisgtgts tfqrhrdsht tqvihqlrls enesvalqel
     1801 ldwrrklcee gqdwqqilhh aeprvppppp ckkpsllkkp egascnrlps elwdtti
//
LOCUS       XP_047286140            1370 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-XVI isoform X4 [Homo sapiens].
ACCESSION   XP_047286140
VERSION     XP_047286140.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430184.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1370
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1370
                     /product="unconventional myosin-XVI isoform X4"
                     /calculated_mol_wt=151134
     Region          9..645
                     /region_name="Motor_domain"
                     /note="Myosin and Kinesin motor domain; cl22853"
                     /db_xref="CDD:473979"
     Site            order(9..16,54..55,290..295)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276814"
     Region          733..1080
                     /region_name="NYAP_N"
                     /note="Neuronal tyrosine-phosphorylated
                     phosphoinositide-3-kinase adapter; pfam15439"
                     /db_xref="CDD:464717"
     Region          1142..>1211
                     /region_name="NYAP_C"
                     /note="Neuronal tyrosine-phosphorylated
                     phosphoinositide-3-kinase adapter; pfam15452"
                     /db_xref="CDD:464724"
     CDS             1..1370
                     /gene="MYO16"
                     /gene_synonym="MYAP3; Myo16b; MYR8; NYAP3; PPP1R107"
                     /coded_by="XM_047430184.1:379..4491"
                     /db_xref="GeneID:23026"
                     /db_xref="HGNC:HGNC:29822"
                     /db_xref="MIM:615479"
ORIGIN      
        1 mrradtrdge rgsgkseask qiirhltcra gasratldsr fkhvvcilea fghakttlnd
       61 lsscfikyfe lqfcerkqql tgariytyll eksrlvsqpl gqsnflifyl lmdglsaeek
      121 yglhlnnlca hrylnqtiqd dastgersln reklavlkra lnvvgfssle venlfvilaa
      181 ilhlgdirft alnegnsafv sdlqlleqva gmlqvstdel asalttdiqy fkgdmiirrh
      241 tiqiaeffrd llakslysrl fsflvntmns clhsqdeqks mqtldigild ifgfeefqkn
      301 efeqlcvnmt nekmhhyine vlflheqvec vqegvtmeta yspgnqngvl dfffqkpsgf
      361 ltlldeesqm iwsvesnfpk klqsllessn tnavyspmkd gngnvalkdh gtaftimhya
      421 grvmydvvga ieknkdslsq nllfvmktse nvvinhlfqs klsqtgslvs aypsfkfrgh
      481 ksallskkmt assiigenkn ylelskllkk kgtstflqrl ergdpvtias qlrkslmdii
      541 gklqkctphf ihcirpnnsk lpdtfdnfyv saqlqyigvl emvkifrygy pvrlsfsdfl
      601 srykpladtf lrekkeqsaa ercrlvlqqc klqgwqmgvr kvflkywhad qlndlclqlq
      661 rkiitcqkvi rgflarqhll qrisirqqev tsinsflqnt edmglktyda lviqnasdia
      721 rendrlrsem napyhkekle vrnmqeegsk rtddksgprh fhpssmsvca avdglgqclv
      781 gpsiwspslh svfsmddsss lpsprkqppp kpkrdpntrl sasyeavsac lsaareaane
      841 alarprphsd dystmkkipp rkpkrspntk lsgsyeeisg srpgdarpag apgaaarvlt
      901 pgtpqcalpp aappgdedds epvyiemlgh aarpdspdpg esvyeemkcc lpddggpgag
      961 sfllhgaspp llhrapedea agppgdacdi pppfpnllph rppllvfppt pvtcspasde
     1021 spltplevkk lpvletnlky pvqpegsspl spqysksqkg dgdrpaspgl alfngsgras
     1081 ppstpppppp ppgpppapyr pcahlafppe papvnagkag psaeapkvhp kpnsapvagp
     1141 cssfpkipys pvkatradar kagssasppa pysppssrpl sspldelasl fnsgrsvlrk
     1201 saagrkirea egfetnmnis srddpstsei tsetqdrnan nhgiqlsnsl ssaitaengn
     1261 sisnglpeed gysrlsisgt gtstfqrhrd shttqvihql rlsenesval qelldwrrkl
     1321 ceegqdwqqi lhhaeprvpp pppckkpsll kkpegascnr lpselwdtti
//
LOCUS       XP_047286141            1243 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-XVI isoform X5 [Homo sapiens].
ACCESSION   XP_047286141
VERSION     XP_047286141.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430185.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1243
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1243
                     /product="unconventional myosin-XVI isoform X5"
                     /calculated_mol_wt=136782
     Region          <5..518
                     /region_name="Motor_domain"
                     /note="Myosin and Kinesin motor domain; cl22853"
                     /db_xref="CDD:473979"
     Region          606..953
                     /region_name="NYAP_N"
                     /note="Neuronal tyrosine-phosphorylated
                     phosphoinositide-3-kinase adapter; pfam15439"
                     /db_xref="CDD:464717"
     Region          1015..>1084
                     /region_name="NYAP_C"
                     /note="Neuronal tyrosine-phosphorylated
                     phosphoinositide-3-kinase adapter; pfam15452"
                     /db_xref="CDD:464724"
     CDS             1..1243
                     /gene="MYO16"
                     /gene_synonym="MYAP3; Myo16b; MYR8; NYAP3; PPP1R107"
                     /coded_by="XM_047430185.1:120..3851"
                     /db_xref="GeneID:23026"
                     /db_xref="HGNC:HGNC:29822"
                     /db_xref="MIM:615479"
ORIGIN      
        1 mfkkrylnqt iqddastger slnreklavl kralnvvgfs slevenlfvi laailhlgdi
       61 rftalnegns afvsdlqlle qvagmlqvst delasalttd iqyfkgdmii rrhtiqiaef
      121 frdllaksly srlfsflvnt mnsclhsqde qksmqtldig ildifgfeef qknefeqlcv
      181 nmtnekmhhy inevlflheq vecvqegvtm etayspgnqn gvldfffqkp sgfltlldee
      241 sqmiwsvesn fpkklqslle ssntnavysp mkdgngnval kdhgtaftim hyagrvmydv
      301 vgaieknkds lsqnllfvmk tsenvvinhl fqsklsqtgs lvsaypsfkf rghksallsk
      361 kmtassiige nknylelskl lkkkgtstfl qrlergdpvt iasqlrkslm diigklqkct
      421 phfihcirpn nsklpdtfdn fyvsaqlqyi gvlemvkifr ygypvrlsfs dflsrykpla
      481 dtflrekkeq saaercrlvl qqcklqgwqm gvrkvflkyw hadqlndlcl qlqrkiitcq
      541 kvirgflarq hllqrisirq qevtsinsfl qntedmglkt ydalviqnas diarendrlr
      601 semnapyhke klevrnmqee gskrtddksg prhfhpssms vcaavdglgq clvgpsiwsp
      661 slhsvfsmdd ssslpsprkq pppkpkrdpn trlsasyeav saclsaarea anealarprp
      721 hsddystmkk ipprkpkrsp ntklsgsyee isgsrpgdar pagapgaaar vltpgtpqca
      781 lppaappgde ddsepvyiem lghaarpdsp dpgesvyeem kcclpddggp gagsfllhga
      841 sppllhrape deaagppgda cdipppfpnl lphrppllvf pptpvtcspa sdespltple
      901 vkklpvletn lkypvqpegs splspqysks qkgdgdrpas pglalfngsg rasppstppp
      961 pppppgpppa pyrpcahlaf ppepapvnag kagpsaeapk vhpkpnsapv agpcssfpki
     1021 pyspvkatra darkagssas ppapysppss rplsspldel aslfnsgrsv lrksaagrki
     1081 reaegfetnm nissrddpst seitsetqdr nannhgiqls nslssaitae ngnsisnglp
     1141 eedgysrlsi sgtgtstfqr hrdshttqvi hqlrlsenes valqelldwr rklceegqdw
     1201 qqilhhaepr vpppppckkp sllkkpegas cnrlpselwd tti
//
LOCUS       XP_005266355            1448 aa            linear   PRI 05-AUG-2025
DEFINITION  sister chromatid cohesion protein PDS5 homolog B isoform X1 [Homo
            sapiens].
ACCESSION   XP_005266355
VERSION     XP_005266355.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266298.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1448
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1448
                     /product="sister chromatid cohesion protein PDS5 homolog B
                     isoform X1"
                     /calculated_mol_wt=164624
     Region          29..1099
                     /region_name="PDS5"
                     /note="Sister chromatid cohesion protein PDS5 protein;
                     pfam20168"
                     /db_xref="CDD:466319"
     Region          240..261
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Site            order(253..254,257,260..261,290..291,294,297..298,303,
                     331..332,335,338,368..369,372,375..376,406..407)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          273..303
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          313..339
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          350..376
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          <1042..1295
                     /region_name="PTZ00449"
                     /note="104 kDa microneme/rhoptry antigen; Provisional"
                     /db_xref="CDD:185628"
     CDS             1..1448
                     /gene="PDS5B"
                     /gene_synonym="APRIN; AS3; CG008"
                     /coded_by="XM_005266298.5:162..4508"
                     /db_xref="GeneID:23047"
                     /db_xref="HGNC:HGNC:20418"
                     /db_xref="MIM:605333"
ORIGIN      
        1 mahsktrtnd gkityppgvk eisdkiskee mvrrlkmvvk tfmdmdqdse eekelylnla
       61 lhlasdfflk hpdkdvrllv accladifri yapeapytsp dklkdifmfi trqlkgledt
      121 kspqfnryfy lleniawvks ynicfeleds neiftqlyrt lfsvinnghn qkvhmhmvdl
      181 mssiicegdt vsqelldtvl vnlvpahknl nkqaydlaka llkrtaqaie pyitnffnqv
      241 lmlgktsisd lsehvfdlil elynidshll lsvlpqlefk lksndneerl qvvkllakmf
      301 gakdselasq nkplwqcylg rfndihvpir lecvkfashc lmnhpdlakd lteylkvrsh
      361 dpeeairhdv ivsivtaakk dillvndhll nfvrertldk rwrvrkeamm glaqiykkya
      421 lqsaagkdaa kqiawikdkl lhiyyqnsid drllverifa qymvphnlet termkclyyl
      481 yatldlnavk alnemwkcqn llrhqvkdll dlikqpktda svkaifskvm vitrnlpdpg
      541 kaqdfmkkft qvleddekir kqlevlvspt csckqaegcv reitkklgnp kqptnpflem
      601 ikflleriap vhidtesisa likqvnksid gtaddedegv ptdqairagl ellkvlsfth
      661 pisfhsaetf esllaclkmd dekvaeaalq ifkntgskie edfphirsal lpvlhhkskk
      721 gpprqakyai hcihaifssk etqfaqifep lhksldpsnl ehlitplvti ghiallapdq
      781 faaplkslva tfivkdllmn drlpgkkttk lwvpdeevsp etmvkiqaik mmvrwllgmk
      841 nnhsksgtst lrllttilhs dgdlteqgki skpdmsrlrl aagsaivkla qepcyheiit
      901 leqyqlcala indecyqvrq vfaqklhkgl srlrlpleym aicalcakdp vkerraharq
      961 clvkninvrr eylkqhaavs ekllsllpey vvpytihlla hdpdyvkvqd ieqlkdvkec
     1021 lwfvleilma knennshafi rkmvenikqt kdaqgpddak mneklytvcd vamniimsks
     1081 ttyslespkd pvlparfftq pdknfsntkn ylppemksff tpgkpkttnv lgavnkplss
     1141 agkqsqtkss rmetvsnass ssnpsspgri kgrldssemd hsenedytms splpgkksdk
     1201 rddsdlvrse lekprgrkkt pvteqeeklg mddltklvqe qkpkgsqrsr krghtasesd
     1261 eqqwpeekrl kedilenede qnsppkkgkr grppkplggg tpkeeptmkt skkgskkksg
     1321 ppapeeeeee erqsgnteqk skskqhrvsr raqqsraesp essaiestqs tpqkgrgrps
     1381 ktpspsqpkk nvrvgrskqa atkendssee vdvfqgsspv ddipqeetee eevstvnvrr
     1441 rsakrerr
//
LOCUS       XP_011533301            1446 aa            linear   PRI 05-AUG-2025
DEFINITION  sister chromatid cohesion protein PDS5 homolog B isoform X2 [Homo
            sapiens].
ACCESSION   XP_011533301
VERSION     XP_011533301.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534999.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1446
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1446
                     /product="sister chromatid cohesion protein PDS5 homolog B
                     isoform X2"
                     /calculated_mol_wt=164369
     Region          29..1099
                     /region_name="PDS5"
                     /note="Sister chromatid cohesion protein PDS5 protein;
                     pfam20168"
                     /db_xref="CDD:466319"
     Region          240..261
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Site            order(253..254,257,260..261,290..291,294,297..298,303,
                     331..332,335,338,368..369,372,375..376,406..407)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          273..303
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          313..339
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          350..376
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     CDS             1..1446
                     /gene="PDS5B"
                     /gene_synonym="APRIN; AS3; CG008"
                     /coded_by="XM_011534999.3:162..4502"
                     /db_xref="GeneID:23047"
                     /db_xref="HGNC:HGNC:20418"
                     /db_xref="MIM:605333"
ORIGIN      
        1 mahsktrtnd gkityppgvk eisdkiskee mvrrlkmvvk tfmdmdqdse eekelylnla
       61 lhlasdfflk hpdkdvrllv accladifri yapeapytsp dklkdifmfi trqlkgledt
      121 kspqfnryfy lleniawvks ynicfeleds neiftqlyrt lfsvinnghn qkvhmhmvdl
      181 mssiicegdt vsqelldtvl vnlvpahknl nkqaydlaka llkrtaqaie pyitnffnqv
      241 lmlgktsisd lsehvfdlil elynidshll lsvlpqlefk lksndneerl qvvkllakmf
      301 gakdselasq nkplwqcylg rfndihvpir lecvkfashc lmnhpdlakd lteylkvrsh
      361 dpeeairhdv ivsivtaakk dillvndhll nfvrertldk rwrvrkeamm glaqiykkya
      421 lqsaagkdaa kqiawikdkl lhiyyqnsid drllverifa qymvphnlet termkclyyl
      481 yatldlnavk alnemwkcqn llrhqvkdll dlikqpktda svkaifskvm vitrnlpdpg
      541 kaqdfmkkft qvleddekir kqlevlvspt csckqaegcv reitkklgnp kqptnpflem
      601 ikflleriap vhidtesisa likqvnksid gtaddedegv ptdqairagl ellkvlsfth
      661 pisfhsaetf esllaclkmd dekvaeaalq ifkntgskie edfphirsal lpvlhhkskk
      721 gpprqakyai hcihaifssk etqfaqifep lhksldpsnl ehlitplvti ghiallapdq
      781 faaplkslva tfivkdllmn drlpgkkttk lwvpdeevsp etmvkiqaik mmvrwllgmk
      841 nnhsksgtst lrllttilhs dgdlteqgki skpdmsrlrl aagsaivkla qepcyheiit
      901 leqyqlcala indecyqvrq vfaqklhkgl srlrlpleym aicalcakdp vkerraharq
      961 clvkninvrr eylkqhaavs ekllsllpey vvpytihlla hdpdyvkvqd ieqlkdvkec
     1021 lwfvleilma knennshafi rkmvenikqt kdaqgpddak mneklytvcd vamniimsks
     1081 ttyslespkd pvlparfftq pdknfsntkn ylppemksff tpgkpkttnv lgavnkplss
     1141 agkqsqtkss rmetvsnass ssnpsspgri kgrldssemd hsenedytms splpgkksdk
     1201 rddsdlsele kprgrkktpv teqeeklgmd dltklvqeqk pkgsqrsrkr ghtasesdeq
     1261 qwpeekrlke dilenedeqn sppkkgkrgr ppkplgggtp keeptmktsk kgskkksgpp
     1321 apeeeeeeer qsgnteqksk skqhrvsrra qqsraespes saiestqstp qkgrgrpskt
     1381 pspsqpkknv rvgrskqaat kendsseevd vfqgsspvdd ipqeeteeee vstvnvrrrs
     1441 akrerr
//
LOCUS       XP_011533302            1445 aa            linear   PRI 05-AUG-2025
DEFINITION  sister chromatid cohesion protein PDS5 homolog B isoform X3 [Homo
            sapiens].
ACCESSION   XP_011533302
VERSION     XP_011533302.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535000.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1445
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1445
                     /product="sister chromatid cohesion protein PDS5 homolog B
                     isoform X3"
                     /calculated_mol_wt=164282
     Region          29..1099
                     /region_name="PDS5"
                     /note="Sister chromatid cohesion protein PDS5 protein;
                     pfam20168"
                     /db_xref="CDD:466319"
     Region          240..261
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Site            order(253..254,257,260..261,290..291,294,297..298,303,
                     331..332,335,338,368..369,372,375..376,406..407)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          273..303
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          313..339
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          350..376
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          <1205..>1408
                     /region_name="PTZ00449"
                     /note="104 kDa microneme/rhoptry antigen; Provisional"
                     /db_xref="CDD:185628"
     CDS             1..1445
                     /gene="PDS5B"
                     /gene_synonym="APRIN; AS3; CG008"
                     /coded_by="XM_011535000.3:162..4499"
                     /db_xref="GeneID:23047"
                     /db_xref="HGNC:HGNC:20418"
                     /db_xref="MIM:605333"
ORIGIN      
        1 mahsktrtnd gkityppgvk eisdkiskee mvrrlkmvvk tfmdmdqdse eekelylnla
       61 lhlasdfflk hpdkdvrllv accladifri yapeapytsp dklkdifmfi trqlkgledt
      121 kspqfnryfy lleniawvks ynicfeleds neiftqlyrt lfsvinnghn qkvhmhmvdl
      181 mssiicegdt vsqelldtvl vnlvpahknl nkqaydlaka llkrtaqaie pyitnffnqv
      241 lmlgktsisd lsehvfdlil elynidshll lsvlpqlefk lksndneerl qvvkllakmf
      301 gakdselasq nkplwqcylg rfndihvpir lecvkfashc lmnhpdlakd lteylkvrsh
      361 dpeeairhdv ivsivtaakk dillvndhll nfvrertldk rwrvrkeamm glaqiykkya
      421 lqsaagkdaa kqiawikdkl lhiyyqnsid drllverifa qymvphnlet termkclyyl
      481 yatldlnavk alnemwkcqn llrhqvkdll dlikqpktda svkaifskvm vitrnlpdpg
      541 kaqdfmkkft qvleddekir kqlevlvspt csckqaegcv reitkklgnp kqptnpflem
      601 ikflleriap vhidtesisa likqvnksid gtaddedegv ptdqairagl ellkvlsfth
      661 pisfhsaetf esllaclkmd dekvaeaalq ifkntgskie edfphirsal lpvlhhkskk
      721 gpprqakyai hcihaifssk etqfaqifep lhksldpsnl ehlitplvti ghiallapdq
      781 faaplkslva tfivkdllmn drlpgkkttk lwvpdeevsp etmvkiqaik mmvrwllgmk
      841 nnhsksgtst lrllttilhs dgdlteqgki skpdmsrlrl aagsaivkla qepcyheiit
      901 leqyqlcala indecyqvrq vfaqklhkgl srlrlpleym aicalcakdp vkerraharq
      961 clvkninvrr eylkqhaavs ekllsllpey vvpytihlla hdpdyvkvqd ieqlkdvkec
     1021 lwfvleilma knennshafi rkmvenikqt kdaqgpddak mneklytvcd vamniimsks
     1081 ttyslespkd pvlparfftq pdknfsntkn ylppemksff tpgkpkttnv lgavnkplss
     1141 agkqsqtkss rmetvsnass ssnpsspgri kgrldssemd hsenedytms splpgkksdk
     1201 rddsdlsele kprgrkktpv teqeeklgmd dltklvqeqk pkgsqrsrkr ghtasesdeq
     1261 qwpeekrlke dilenedeqn sppkkgkrgr ppkplgggtp keeptmktsk kgskkksgpp
     1321 apeeeeeeer qsgnteqksk skqhrvsrra qqraespess aiestqstpq kgrgrpsktp
     1381 spsqpkknvr vgrskqaatk endsseevdv fqgsspvddi pqeeteeeev stvnvrrrsa
     1441 krerr
//
LOCUS       XP_016875941            1411 aa            linear   PRI 05-AUG-2025
DEFINITION  sister chromatid cohesion protein PDS5 homolog B isoform X4 [Homo
            sapiens].
ACCESSION   XP_016875941
VERSION     XP_016875941.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020452.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1411
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1411
                     /product="sister chromatid cohesion protein PDS5 homolog B
                     isoform X4"
                     /calculated_mol_wt=160706
     Region          29..1099
                     /region_name="PDS5"
                     /note="Sister chromatid cohesion protein PDS5 protein;
                     pfam20168"
                     /db_xref="CDD:466319"
     Region          240..261
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Site            order(253..254,257,260..261,290..291,294,297..298,303,
                     331..332,335,338,368..369,372,375..376,406..407)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          273..303
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          313..339
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          350..376
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          <1042..1295
                     /region_name="PTZ00449"
                     /note="104 kDa microneme/rhoptry antigen; Provisional"
                     /db_xref="CDD:185628"
     CDS             1..1411
                     /gene="PDS5B"
                     /gene_synonym="APRIN; AS3; CG008"
                     /coded_by="XM_017020452.3:162..4397"
                     /db_xref="GeneID:23047"
                     /db_xref="HGNC:HGNC:20418"
                     /db_xref="MIM:605333"
ORIGIN      
        1 mahsktrtnd gkityppgvk eisdkiskee mvrrlkmvvk tfmdmdqdse eekelylnla
       61 lhlasdfflk hpdkdvrllv accladifri yapeapytsp dklkdifmfi trqlkgledt
      121 kspqfnryfy lleniawvks ynicfeleds neiftqlyrt lfsvinnghn qkvhmhmvdl
      181 mssiicegdt vsqelldtvl vnlvpahknl nkqaydlaka llkrtaqaie pyitnffnqv
      241 lmlgktsisd lsehvfdlil elynidshll lsvlpqlefk lksndneerl qvvkllakmf
      301 gakdselasq nkplwqcylg rfndihvpir lecvkfashc lmnhpdlakd lteylkvrsh
      361 dpeeairhdv ivsivtaakk dillvndhll nfvrertldk rwrvrkeamm glaqiykkya
      421 lqsaagkdaa kqiawikdkl lhiyyqnsid drllverifa qymvphnlet termkclyyl
      481 yatldlnavk alnemwkcqn llrhqvkdll dlikqpktda svkaifskvm vitrnlpdpg
      541 kaqdfmkkft qvleddekir kqlevlvspt csckqaegcv reitkklgnp kqptnpflem
      601 ikflleriap vhidtesisa likqvnksid gtaddedegv ptdqairagl ellkvlsfth
      661 pisfhsaetf esllaclkmd dekvaeaalq ifkntgskie edfphirsal lpvlhhkskk
      721 gpprqakyai hcihaifssk etqfaqifep lhksldpsnl ehlitplvti ghiallapdq
      781 faaplkslva tfivkdllmn drlpgkkttk lwvpdeevsp etmvkiqaik mmvrwllgmk
      841 nnhsksgtst lrllttilhs dgdlteqgki skpdmsrlrl aagsaivkla qepcyheiit
      901 leqyqlcala indecyqvrq vfaqklhkgl srlrlpleym aicalcakdp vkerraharq
      961 clvkninvrr eylkqhaavs ekllsllpey vvpytihlla hdpdyvkvqd ieqlkdvkec
     1021 lwfvleilma knennshafi rkmvenikqt kdaqgpddak mneklytvcd vamniimsks
     1081 ttyslespkd pvlparfftq pdknfsntkn ylppemksff tpgkpkttnv lgavnkplss
     1141 agkqsqtkss rmetvsnass ssnpsspgri kgrldssemd hsenedytms splpgkksdk
     1201 rddsdlvrse lekprgrkkt pvteqeeklg mddltklvqe qkpkgsqrsr krghtasesd
     1261 eqqwpeekrl kedilenede qnsppkkgkr grppkplggg tpkeeptmkt skkgskkksg
     1321 ppapeeeeee erqsgnteqk skskqhrvsr raqqsrvgrs kqaatkends seevdvfqgs
     1381 spvddipqee teeeevstvn vrrrsakrer r
//
LOCUS       XP_016875942            1409 aa            linear   PRI 05-AUG-2025
DEFINITION  sister chromatid cohesion protein PDS5 homolog B isoform X5 [Homo
            sapiens].
ACCESSION   XP_016875942
VERSION     XP_016875942.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020453.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1409
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1409
                     /product="sister chromatid cohesion protein PDS5 homolog B
                     isoform X5"
                     /calculated_mol_wt=160450
     Region          29..1099
                     /region_name="PDS5"
                     /note="Sister chromatid cohesion protein PDS5 protein;
                     pfam20168"
                     /db_xref="CDD:466319"
     Region          240..261
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Site            order(253..254,257,260..261,290..291,294,297..298,303,
                     331..332,335,338,368..369,372,375..376,406..407)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          273..303
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          313..339
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          350..376
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     CDS             1..1409
                     /gene="PDS5B"
                     /gene_synonym="APRIN; AS3; CG008"
                     /coded_by="XM_017020453.2:162..4391"
                     /db_xref="GeneID:23047"
                     /db_xref="HGNC:HGNC:20418"
                     /db_xref="MIM:605333"
ORIGIN      
        1 mahsktrtnd gkityppgvk eisdkiskee mvrrlkmvvk tfmdmdqdse eekelylnla
       61 lhlasdfflk hpdkdvrllv accladifri yapeapytsp dklkdifmfi trqlkgledt
      121 kspqfnryfy lleniawvks ynicfeleds neiftqlyrt lfsvinnghn qkvhmhmvdl
      181 mssiicegdt vsqelldtvl vnlvpahknl nkqaydlaka llkrtaqaie pyitnffnqv
      241 lmlgktsisd lsehvfdlil elynidshll lsvlpqlefk lksndneerl qvvkllakmf
      301 gakdselasq nkplwqcylg rfndihvpir lecvkfashc lmnhpdlakd lteylkvrsh
      361 dpeeairhdv ivsivtaakk dillvndhll nfvrertldk rwrvrkeamm glaqiykkya
      421 lqsaagkdaa kqiawikdkl lhiyyqnsid drllverifa qymvphnlet termkclyyl
      481 yatldlnavk alnemwkcqn llrhqvkdll dlikqpktda svkaifskvm vitrnlpdpg
      541 kaqdfmkkft qvleddekir kqlevlvspt csckqaegcv reitkklgnp kqptnpflem
      601 ikflleriap vhidtesisa likqvnksid gtaddedegv ptdqairagl ellkvlsfth
      661 pisfhsaetf esllaclkmd dekvaeaalq ifkntgskie edfphirsal lpvlhhkskk
      721 gpprqakyai hcihaifssk etqfaqifep lhksldpsnl ehlitplvti ghiallapdq
      781 faaplkslva tfivkdllmn drlpgkkttk lwvpdeevsp etmvkiqaik mmvrwllgmk
      841 nnhsksgtst lrllttilhs dgdlteqgki skpdmsrlrl aagsaivkla qepcyheiit
      901 leqyqlcala indecyqvrq vfaqklhkgl srlrlpleym aicalcakdp vkerraharq
      961 clvkninvrr eylkqhaavs ekllsllpey vvpytihlla hdpdyvkvqd ieqlkdvkec
     1021 lwfvleilma knennshafi rkmvenikqt kdaqgpddak mneklytvcd vamniimsks
     1081 ttyslespkd pvlparfftq pdknfsntkn ylppemksff tpgkpkttnv lgavnkplss
     1141 agkqsqtkss rmetvsnass ssnpsspgri kgrldssemd hsenedytms splpgkksdk
     1201 rddsdlsele kprgrkktpv teqeeklgmd dltklvqeqk pkgsqrsrkr ghtasesdeq
     1261 qwpeekrlke dilenedeqn sppkkgkrgr ppkplgggtp keeptmktsk kgskkksgpp
     1321 apeeeeeeer qsgnteqksk skqhrvsrra qqsrvgrskq aatkendsse evdvfqgssp
     1381 vddipqeete eeevstvnvr rrsakrerr
//
LOCUS       XP_047286142            1448 aa            linear   PRI 05-AUG-2025
DEFINITION  sister chromatid cohesion protein PDS5 homolog B isoform X1 [Homo
            sapiens].
ACCESSION   XP_047286142
VERSION     XP_047286142.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430186.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1448
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1448
                     /product="sister chromatid cohesion protein PDS5 homolog B
                     isoform X1"
                     /calculated_mol_wt=164624
     Region          29..1099
                     /region_name="PDS5"
                     /note="Sister chromatid cohesion protein PDS5 protein;
                     pfam20168"
                     /db_xref="CDD:466319"
     Region          240..261
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Site            order(253..254,257,260..261,290..291,294,297..298,303,
                     331..332,335,338,368..369,372,375..376,406..407)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          273..303
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          313..339
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          350..376
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          <1042..1295
                     /region_name="PTZ00449"
                     /note="104 kDa microneme/rhoptry antigen; Provisional"
                     /db_xref="CDD:185628"
     CDS             1..1448
                     /gene="PDS5B"
                     /gene_synonym="APRIN; AS3; CG008"
                     /coded_by="XM_047430186.1:160..4506"
                     /db_xref="GeneID:23047"
                     /db_xref="HGNC:HGNC:20418"
                     /db_xref="MIM:605333"
ORIGIN      
        1 mahsktrtnd gkityppgvk eisdkiskee mvrrlkmvvk tfmdmdqdse eekelylnla
       61 lhlasdfflk hpdkdvrllv accladifri yapeapytsp dklkdifmfi trqlkgledt
      121 kspqfnryfy lleniawvks ynicfeleds neiftqlyrt lfsvinnghn qkvhmhmvdl
      181 mssiicegdt vsqelldtvl vnlvpahknl nkqaydlaka llkrtaqaie pyitnffnqv
      241 lmlgktsisd lsehvfdlil elynidshll lsvlpqlefk lksndneerl qvvkllakmf
      301 gakdselasq nkplwqcylg rfndihvpir lecvkfashc lmnhpdlakd lteylkvrsh
      361 dpeeairhdv ivsivtaakk dillvndhll nfvrertldk rwrvrkeamm glaqiykkya
      421 lqsaagkdaa kqiawikdkl lhiyyqnsid drllverifa qymvphnlet termkclyyl
      481 yatldlnavk alnemwkcqn llrhqvkdll dlikqpktda svkaifskvm vitrnlpdpg
      541 kaqdfmkkft qvleddekir kqlevlvspt csckqaegcv reitkklgnp kqptnpflem
      601 ikflleriap vhidtesisa likqvnksid gtaddedegv ptdqairagl ellkvlsfth
      661 pisfhsaetf esllaclkmd dekvaeaalq ifkntgskie edfphirsal lpvlhhkskk
      721 gpprqakyai hcihaifssk etqfaqifep lhksldpsnl ehlitplvti ghiallapdq
      781 faaplkslva tfivkdllmn drlpgkkttk lwvpdeevsp etmvkiqaik mmvrwllgmk
      841 nnhsksgtst lrllttilhs dgdlteqgki skpdmsrlrl aagsaivkla qepcyheiit
      901 leqyqlcala indecyqvrq vfaqklhkgl srlrlpleym aicalcakdp vkerraharq
      961 clvkninvrr eylkqhaavs ekllsllpey vvpytihlla hdpdyvkvqd ieqlkdvkec
     1021 lwfvleilma knennshafi rkmvenikqt kdaqgpddak mneklytvcd vamniimsks
     1081 ttyslespkd pvlparfftq pdknfsntkn ylppemksff tpgkpkttnv lgavnkplss
     1141 agkqsqtkss rmetvsnass ssnpsspgri kgrldssemd hsenedytms splpgkksdk
     1201 rddsdlvrse lekprgrkkt pvteqeeklg mddltklvqe qkpkgsqrsr krghtasesd
     1261 eqqwpeekrl kedilenede qnsppkkgkr grppkplggg tpkeeptmkt skkgskkksg
     1321 ppapeeeeee erqsgnteqk skskqhrvsr raqqsraesp essaiestqs tpqkgrgrps
     1381 ktpspsqpkk nvrvgrskqa atkendssee vdvfqgsspv ddipqeetee eevstvnvrr
     1441 rsakrerr
//
LOCUS       XP_016875937            1448 aa            linear   PRI 05-AUG-2025
DEFINITION  sister chromatid cohesion protein PDS5 homolog B isoform X1 [Homo
            sapiens].
ACCESSION   XP_016875937
VERSION     XP_016875937.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020448.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1448
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1448
                     /product="sister chromatid cohesion protein PDS5 homolog B
                     isoform X1"
                     /calculated_mol_wt=164624
     Region          29..1099
                     /region_name="PDS5"
                     /note="Sister chromatid cohesion protein PDS5 protein;
                     pfam20168"
                     /db_xref="CDD:466319"
     Region          240..261
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Site            order(253..254,257,260..261,290..291,294,297..298,303,
                     331..332,335,338,368..369,372,375..376,406..407)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          273..303
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          313..339
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          350..376
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          <1042..1295
                     /region_name="PTZ00449"
                     /note="104 kDa microneme/rhoptry antigen; Provisional"
                     /db_xref="CDD:185628"
     CDS             1..1448
                     /gene="PDS5B"
                     /gene_synonym="APRIN; AS3; CG008"
                     /coded_by="XM_017020448.2:332..4678"
                     /db_xref="GeneID:23047"
                     /db_xref="HGNC:HGNC:20418"
                     /db_xref="MIM:605333"
ORIGIN      
        1 mahsktrtnd gkityppgvk eisdkiskee mvrrlkmvvk tfmdmdqdse eekelylnla
       61 lhlasdfflk hpdkdvrllv accladifri yapeapytsp dklkdifmfi trqlkgledt
      121 kspqfnryfy lleniawvks ynicfeleds neiftqlyrt lfsvinnghn qkvhmhmvdl
      181 mssiicegdt vsqelldtvl vnlvpahknl nkqaydlaka llkrtaqaie pyitnffnqv
      241 lmlgktsisd lsehvfdlil elynidshll lsvlpqlefk lksndneerl qvvkllakmf
      301 gakdselasq nkplwqcylg rfndihvpir lecvkfashc lmnhpdlakd lteylkvrsh
      361 dpeeairhdv ivsivtaakk dillvndhll nfvrertldk rwrvrkeamm glaqiykkya
      421 lqsaagkdaa kqiawikdkl lhiyyqnsid drllverifa qymvphnlet termkclyyl
      481 yatldlnavk alnemwkcqn llrhqvkdll dlikqpktda svkaifskvm vitrnlpdpg
      541 kaqdfmkkft qvleddekir kqlevlvspt csckqaegcv reitkklgnp kqptnpflem
      601 ikflleriap vhidtesisa likqvnksid gtaddedegv ptdqairagl ellkvlsfth
      661 pisfhsaetf esllaclkmd dekvaeaalq ifkntgskie edfphirsal lpvlhhkskk
      721 gpprqakyai hcihaifssk etqfaqifep lhksldpsnl ehlitplvti ghiallapdq
      781 faaplkslva tfivkdllmn drlpgkkttk lwvpdeevsp etmvkiqaik mmvrwllgmk
      841 nnhsksgtst lrllttilhs dgdlteqgki skpdmsrlrl aagsaivkla qepcyheiit
      901 leqyqlcala indecyqvrq vfaqklhkgl srlrlpleym aicalcakdp vkerraharq
      961 clvkninvrr eylkqhaavs ekllsllpey vvpytihlla hdpdyvkvqd ieqlkdvkec
     1021 lwfvleilma knennshafi rkmvenikqt kdaqgpddak mneklytvcd vamniimsks
     1081 ttyslespkd pvlparfftq pdknfsntkn ylppemksff tpgkpkttnv lgavnkplss
     1141 agkqsqtkss rmetvsnass ssnpsspgri kgrldssemd hsenedytms splpgkksdk
     1201 rddsdlvrse lekprgrkkt pvteqeeklg mddltklvqe qkpkgsqrsr krghtasesd
     1261 eqqwpeekrl kedilenede qnsppkkgkr grppkplggg tpkeeptmkt skkgskkksg
     1321 ppapeeeeee erqsgnteqk skskqhrvsr raqqsraesp essaiestqs tpqkgrgrps
     1381 ktpspsqpkk nvrvgrskqa atkendssee vdvfqgsspv ddipqeetee eevstvnvrr
     1441 rsakrerr
//
LOCUS       XP_011533304            1172 aa            linear   PRI 05-AUG-2025
DEFINITION  sister chromatid cohesion protein PDS5 homolog B isoform X6 [Homo
            sapiens].
ACCESSION   XP_011533304
VERSION     XP_011533304.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535002.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1172
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1172
                     /product="sister chromatid cohesion protein PDS5 homolog B
                     isoform X6"
                     /calculated_mol_wt=132715
     Region          <4..823
                     /region_name="PDS5"
                     /note="Sister chromatid cohesion protein PDS5 protein;
                     pfam20168"
                     /db_xref="CDD:466319"
     Region          <766..1019
                     /region_name="PTZ00449"
                     /note="104 kDa microneme/rhoptry antigen; Provisional"
                     /db_xref="CDD:185628"
     CDS             1..1172
                     /gene="PDS5B"
                     /gene_synonym="APRIN; AS3; CG008"
                     /coded_by="XM_011535002.4:113..3631"
                     /db_xref="GeneID:23047"
                     /db_xref="HGNC:HGNC:20418"
                     /db_xref="MIM:605333"
ORIGIN      
        1 mqkhiesndn eerlqvvkll akmfgakdse lasqnkplwq cylgrfndih vpirlecvkf
       61 ashclmnhpd lakdlteylk vrshdpeeai rhdvivsivt aakkdillvn dhllnfvrer
      121 tldkrwrvrk eammglaqiy kkyalqsaag kdaakqiawi kdkllhiyyq nsiddrllve
      181 rifaqymvph nlettermkc lyylyatldl navkalnemw kcqnllrhqv kdlldlikqp
      241 ktdasvkaif skvmvitrnl pdpgkaqdfm kkftqvledd ekirkqlevl vsptcsckqa
      301 egcvreitkk lgnpkqptnp flemikflle riapvhidte sisalikqvn ksidgtadde
      361 degvptdqai raglellkvl sfthpisfhs aetfesllac lkmddekvae aalqifkntg
      421 skieedfphi rsallpvlhh kskkgpprqa kyaihcihai fssketqfaq ifeplhksld
      481 psnlehlitp lvtighiall apdqfaaplk slvatfivkd llmndrlpgk kttklwvpde
      541 evspetmvki qaikmmvrwl lgmknnhsks gtstlrlltt ilhsdgdlte qgkiskpdms
      601 rlrlaagsai vklaqepcyh eiitleqyql calaindecy qvrqvfaqkl hkglsrlrlp
      661 leymaicalc akdpvkerra harqclvkni nvrreylkqh aavsekllsl lpeyvvpyti
      721 hllahdpdyv kvqdieqlkd vkeclwfvle ilmaknenns hafirkmven ikqtkdaqgp
      781 ddakmnekly tvcdvamnii msksttysle spkdpvlpar fftqpdknfs ntknylppem
      841 ksfftpgkpk ttnvlgavnk plssagkqsq tkssrmetvs nassssnpss pgrikgrlds
      901 semdhsened ytmssplpgk ksdkrddsdl vrselekprg rkktpvteqe eklgmddltk
      961 lvqeqkpkgs qrsrkrghta sesdeqqwpe ekrlkedile nedeqnsppk kgkrgrppkp
     1021 lgggtpkeep tmktskkgsk kksgppapee eeeeerqsgn teqkskskqh rvsrraqqsr
     1081 aespessaie stqstpqkgr grpsktpsps qpkknvrvgr skqaatkend sseevdvfqg
     1141 sspvddipqe eteeeevstv nvrrrsakre rr
//
LOCUS       XP_011533310             474 aa            linear   PRI 05-AUG-2025
DEFINITION  forkhead box protein O1 isoform X1 [Homo sapiens].
ACCESSION   XP_011533310
VERSION     XP_011533310.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535008.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..474
                     /product="forkhead box protein O1 isoform X1"
                     /calculated_mol_wt=51355
     Region          <29..67
                     /region_name="FH_FOX"
                     /note="Forkhead (FH) domain found in Forkhead box (FOX)
                     family of transcription factors and similar proteins;
                     cl00061"
                     /db_xref="CDD:469596"
     Region          242..323
                     /region_name="FOXO_KIX_bdg"
                     /note="KIX-binding domain of forkhead box O, CR2;
                     pfam16675"
                     /db_xref="CDD:465228"
     Region          416..452
                     /region_name="FOXO-TAD"
                     /note="Transactivation domain of FOXO protein family;
                     pfam16676"
                     /db_xref="CDD:435506"
     CDS             1..474
                     /gene="FOXO1"
                     /gene_synonym="FKH1; FKHR; FOXO1A"
                     /coded_by="XM_011535008.3:10081..11505"
                     /db_xref="GeneID:2308"
                     /db_xref="HGNC:HGNC:3819"
                     /db_xref="MIM:136533"
ORIGIN      
        1 mrskhtancl afrcilawpg glaqncwcqn sirhnlslhs kfirvqnegt gksswwmlnp
       61 eggksgkspr rraasmdnns kfaksrsraa kkkaslqsgq egagdspgsq fskwpaspgs
      121 hsnddfdnws tfrprtssna stisgrlspi mteqddlgeg dvhsmvypps aakmastlps
      181 lseisnpenm enlldnlnll ssptsltvst qsspgtmmqq tpcysfappn tslnspspny
      241 qkytygqssm splpqmpiqt lqdnkssygg msqyncapgl lkelltsdsp phndimtpvd
      301 pgvaqpnsrv lgqnvmmgpn svmstygsqa shnkmmnpss hthpghaqqt savngrplph
      361 tvstmphtsg mnrltqvktp vqvplphpmq msalggyssv sscngygrmg llhqeklpsd
      421 ldgmfierld cdmesiirnd lmdgdtldfn fdnvlpnqsf phsvkttths wvsg
//
LOCUS       XP_047286160             418 aa            linear   PRI 05-AUG-2025
DEFINITION  forkhead box protein O1 isoform X2 [Homo sapiens].
ACCESSION   XP_047286160
VERSION     XP_047286160.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430204.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..418
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..418
                     /product="forkhead box protein O1 isoform X2"
                     /calculated_mol_wt=44928
     Region          186..267
                     /region_name="FOXO_KIX_bdg"
                     /note="KIX-binding domain of forkhead box O, CR2;
                     pfam16675"
                     /db_xref="CDD:465228"
     Region          360..396
                     /region_name="FOXO-TAD"
                     /note="Transactivation domain of FOXO protein family;
                     pfam16676"
                     /db_xref="CDD:435506"
     CDS             1..418
                     /gene="FOXO1"
                     /gene_synonym="FKH1; FKHR; FOXO1A"
                     /coded_by="XM_047430204.1:9065..10321"
                     /db_xref="GeneID:2308"
                     /db_xref="HGNC:HGNC:3819"
                     /db_xref="MIM:136533"
ORIGIN      
        1 mlnpeggksg ksprrraasm dnnskfaksr sraakkkasl qsgqegagds pgsqfskwpa
       61 spgshsnddf dnwstfrprt ssnastisgr lspimteqdd lgegdvhsmv yppsaakmas
      121 tlpslseisn penmenlldn lnllssptsl tvstqsspgt mmqqtpcysf appntslnsp
      181 spnyqkytyg qssmsplpqm piqtlqdnks syggmsqync apgllkellt sdspphndim
      241 tpvdpgvaqp nsrvlgqnvm mgpnsvmsty gsqashnkmm npsshthpgh aqqtsavngr
      301 plphtvstmp htsgmnrltq vktpvqvplp hpmqmsalgg yssvsscngy grmgllhqek
      361 lpsdldgmfi erldcdmesi irndlmdgdt ldfnfdnvlp nqsfphsvkt tthswvsg
//
LOCUS       XP_011533312             418 aa            linear   PRI 05-AUG-2025
DEFINITION  forkhead box protein O1 isoform X2 [Homo sapiens].
ACCESSION   XP_011533312
VERSION     XP_011533312.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535010.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..418
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..418
                     /product="forkhead box protein O1 isoform X2"
                     /calculated_mol_wt=44928
     Region          186..267
                     /region_name="FOXO_KIX_bdg"
                     /note="KIX-binding domain of forkhead box O, CR2;
                     pfam16675"
                     /db_xref="CDD:465228"
     Region          360..396
                     /region_name="FOXO-TAD"
                     /note="Transactivation domain of FOXO protein family;
                     pfam16676"
                     /db_xref="CDD:435506"
     CDS             1..418
                     /gene="FOXO1"
                     /gene_synonym="FKH1; FKHR; FOXO1A"
                     /coded_by="XM_011535010.3:40746..42002"
                     /db_xref="GeneID:2308"
                     /db_xref="HGNC:HGNC:3819"
                     /db_xref="MIM:136533"
ORIGIN      
        1 mlnpeggksg ksprrraasm dnnskfaksr sraakkkasl qsgqegagds pgsqfskwpa
       61 spgshsnddf dnwstfrprt ssnastisgr lspimteqdd lgegdvhsmv yppsaakmas
      121 tlpslseisn penmenlldn lnllssptsl tvstqsspgt mmqqtpcysf appntslnsp
      181 spnyqkytyg qssmsplpqm piqtlqdnks syggmsqync apgllkellt sdspphndim
      241 tpvdpgvaqp nsrvlgqnvm mgpnsvmsty gsqashnkmm npsshthpgh aqqtsavngr
      301 plphtvstmp htsgmnrltq vktpvqvplp hpmqmsalgg yssvsscngy grmgllhqek
      361 lpsdldgmfi erldcdmesi irndlmdgdt ldfnfdnvlp nqsfphsvkt tthswvsg
//
LOCUS       XP_005266359            1697 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger CCCH domain-containing protein 13 isoform X1 [Homo
            sapiens].
ACCESSION   XP_005266359
VERSION     XP_005266359.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266302.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1697
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1697
                     /product="zinc finger CCCH domain-containing protein 13
                     isoform X1"
                     /calculated_mol_wt=199546
     Region          42..63
                     /region_name="zf-CCCH"
                     /note="Zinc finger C-x8-C-x5-C-x3-H type (and similar);
                     pfam00642"
                     /db_xref="CDD:459885"
     Region          343..>566
                     /region_name="PRK12678"
                     /note="transcription termination factor Rho; Provisional"
                     /db_xref="CDD:237171"
     CDS             1..1697
                     /gene="ZC3H13"
                     /gene_synonym="KIAA0853; Xio"
                     /coded_by="XM_005266302.4:59..5152"
                     /db_xref="GeneID:23091"
                     /db_xref="HGNC:HGNC:20368"
                     /db_xref="MIM:616453"
ORIGIN      
        1 mskirrkvtv entktisdst srrpsvferl gpstgstaet qcrnwlktgn clygntcrfv
       61 hgpsprgkgy ssnyrrsper ptgdlrermk nkrqdvdtep qkrnteesss pvrkessrgr
      121 hrekedikit kertpeseee nvewetnrdd sdngdinydy vhelslemkr qkiqrelmkl
      181 eqenmekree iiikkevspe vvrsklspsp slrksskspk rksspksssa skkdrktsav
      241 ssplldqqrn sktnqskkkg prtpsppppi pedialgkky kekykvkdri eektrdgkdr
      301 grdferqrek rdkprstspa gqhhspissr hhssssqsgs siqrhspspr rkrtpspsyq
      361 rtltpplrrs aspypshsls spqrkqsppr hrspmrekgr hdhertsqsh drrherredt
      421 rgkrdrekds reereyeqdq sssrdhrddr eprdgrdrrd ardtrdrrel rdsrdmrdsr
      481 emrdysrdtk esrdprdsrs trdahdyrdr egrdthrked typeesrsyg rnhlreessr
      541 teirnesrne srseirndrm grsrgrvpel pekgsrgsrg sqidshssns nyhdswetrs
      601 syperdrype rdnrdqards sferrhgerd rrdnrerapm fytsccpypl ppvfsgpagg
      661 tekirdqrps spirhqgrnd elerderree rrvdrvddrr derarerdre rerdrerere
      721 rererdrere kerelerera rererereke rdrerdrdrd hdrererere rdrekerere
      781 reerererer ererererer ererarerdk ererqrdwed kdkgrddrre kreeiredrn
      841 prdghderks kkryrnegsp sprqspkrrr ehspdsdayn sgddknekhr llsqvvrpqe
      901 srslspshlt edrqgrwkee drkperkess rryeeqelke kvssvdkqre qteilessrm
      961 raqdiighhq sedretsdra hdenkkkaki qkkpikkkke ddvgiergni ettsedgqvf
     1021 spkkgqkkks iekkrkkskg dsdisdeeaa qqskkkrgpr tppittkeel vemcngkngi
     1081 ledsqkkedt afsdwsdedv pdrtevteae htatattpgs tpsplssllp ppppvatata
     1141 ttvpatlaat taaaatsfst saitistsat ptnttnntfa nedshrkchr trvekvetph
     1201 vtiedaqhrk pmdqkrsssl gsnrsnrsht sgrlrspsnd sahrsgddqs grkrvlhsgs
     1261 rdrektksle itgerksrid qlkrgepsrs tssdrqdsrs hssrrsspes drqvhsrsgs
     1321 fdsrdrlqer dryehdrere rerrdtrqre wdrdadkdwp rnrdrdrlre rerererdkr
     1381 rdldrererl isdsverdrd rdrdrtfess qiesvkrcea klegeherdl estsrdslal
     1441 dkermdkdlg svqgfeetnk sertesleag ddesklddah slgsgagegy episddelde
     1501 ilagdaekre dqqdeekmpd pldvidvdws glmpkhpkep repgaallkf tpgavmlrvg
     1561 iskklagsel fakvketcqr llekpkdadn lfehelgaln maallrkeer asllsnlgpc
     1621 ckalcfrrds airkqlvkne kgtikqayts apmvdnellr lslrlfkrkt tchapghekt
     1681 ednklsqssi qqelcvs
//
LOCUS       XP_005266361            1697 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger CCCH domain-containing protein 13 isoform X1 [Homo
            sapiens].
ACCESSION   XP_005266361
VERSION     XP_005266361.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266304.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1697
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1697
                     /product="zinc finger CCCH domain-containing protein 13
                     isoform X1"
                     /calculated_mol_wt=199546
     Region          42..63
                     /region_name="zf-CCCH"
                     /note="Zinc finger C-x8-C-x5-C-x3-H type (and similar);
                     pfam00642"
                     /db_xref="CDD:459885"
     Region          343..>566
                     /region_name="PRK12678"
                     /note="transcription termination factor Rho; Provisional"
                     /db_xref="CDD:237171"
     CDS             1..1697
                     /gene="ZC3H13"
                     /gene_synonym="KIAA0853; Xio"
                     /coded_by="XM_005266304.4:350..5443"
                     /db_xref="GeneID:23091"
                     /db_xref="HGNC:HGNC:20368"
                     /db_xref="MIM:616453"
ORIGIN      
        1 mskirrkvtv entktisdst srrpsvferl gpstgstaet qcrnwlktgn clygntcrfv
       61 hgpsprgkgy ssnyrrsper ptgdlrermk nkrqdvdtep qkrnteesss pvrkessrgr
      121 hrekedikit kertpeseee nvewetnrdd sdngdinydy vhelslemkr qkiqrelmkl
      181 eqenmekree iiikkevspe vvrsklspsp slrksskspk rksspksssa skkdrktsav
      241 ssplldqqrn sktnqskkkg prtpsppppi pedialgkky kekykvkdri eektrdgkdr
      301 grdferqrek rdkprstspa gqhhspissr hhssssqsgs siqrhspspr rkrtpspsyq
      361 rtltpplrrs aspypshsls spqrkqsppr hrspmrekgr hdhertsqsh drrherredt
      421 rgkrdrekds reereyeqdq sssrdhrddr eprdgrdrrd ardtrdrrel rdsrdmrdsr
      481 emrdysrdtk esrdprdsrs trdahdyrdr egrdthrked typeesrsyg rnhlreessr
      541 teirnesrne srseirndrm grsrgrvpel pekgsrgsrg sqidshssns nyhdswetrs
      601 syperdrype rdnrdqards sferrhgerd rrdnrerapm fytsccpypl ppvfsgpagg
      661 tekirdqrps spirhqgrnd elerderree rrvdrvddrr derarerdre rerdrerere
      721 rererdrere kerelerera rererereke rdrerdrdrd hdrererere rdrekerere
      781 reerererer ererererer ererarerdk ererqrdwed kdkgrddrre kreeiredrn
      841 prdghderks kkryrnegsp sprqspkrrr ehspdsdayn sgddknekhr llsqvvrpqe
      901 srslspshlt edrqgrwkee drkperkess rryeeqelke kvssvdkqre qteilessrm
      961 raqdiighhq sedretsdra hdenkkkaki qkkpikkkke ddvgiergni ettsedgqvf
     1021 spkkgqkkks iekkrkkskg dsdisdeeaa qqskkkrgpr tppittkeel vemcngkngi
     1081 ledsqkkedt afsdwsdedv pdrtevteae htatattpgs tpsplssllp ppppvatata
     1141 ttvpatlaat taaaatsfst saitistsat ptnttnntfa nedshrkchr trvekvetph
     1201 vtiedaqhrk pmdqkrsssl gsnrsnrsht sgrlrspsnd sahrsgddqs grkrvlhsgs
     1261 rdrektksle itgerksrid qlkrgepsrs tssdrqdsrs hssrrsspes drqvhsrsgs
     1321 fdsrdrlqer dryehdrere rerrdtrqre wdrdadkdwp rnrdrdrlre rerererdkr
     1381 rdldrererl isdsverdrd rdrdrtfess qiesvkrcea klegeherdl estsrdslal
     1441 dkermdkdlg svqgfeetnk sertesleag ddesklddah slgsgagegy episddelde
     1501 ilagdaekre dqqdeekmpd pldvidvdws glmpkhpkep repgaallkf tpgavmlrvg
     1561 iskklagsel fakvketcqr llekpkdadn lfehelgaln maallrkeer asllsnlgpc
     1621 ckalcfrrds airkqlvkne kgtikqayts apmvdnellr lslrlfkrkt tchapghekt
     1681 ednklsqssi qqelcvs
//
LOCUS       XP_005266362            1697 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger CCCH domain-containing protein 13 isoform X1 [Homo
            sapiens].
ACCESSION   XP_005266362
VERSION     XP_005266362.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266305.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1697
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1697
                     /product="zinc finger CCCH domain-containing protein 13
                     isoform X1"
                     /calculated_mol_wt=199546
     Region          42..63
                     /region_name="zf-CCCH"
                     /note="Zinc finger C-x8-C-x5-C-x3-H type (and similar);
                     pfam00642"
                     /db_xref="CDD:459885"
     Region          343..>566
                     /region_name="PRK12678"
                     /note="transcription termination factor Rho; Provisional"
                     /db_xref="CDD:237171"
     CDS             1..1697
                     /gene="ZC3H13"
                     /gene_synonym="KIAA0853; Xio"
                     /coded_by="XM_005266305.4:408..5501"
                     /db_xref="GeneID:23091"
                     /db_xref="HGNC:HGNC:20368"
                     /db_xref="MIM:616453"
ORIGIN      
        1 mskirrkvtv entktisdst srrpsvferl gpstgstaet qcrnwlktgn clygntcrfv
       61 hgpsprgkgy ssnyrrsper ptgdlrermk nkrqdvdtep qkrnteesss pvrkessrgr
      121 hrekedikit kertpeseee nvewetnrdd sdngdinydy vhelslemkr qkiqrelmkl
      181 eqenmekree iiikkevspe vvrsklspsp slrksskspk rksspksssa skkdrktsav
      241 ssplldqqrn sktnqskkkg prtpsppppi pedialgkky kekykvkdri eektrdgkdr
      301 grdferqrek rdkprstspa gqhhspissr hhssssqsgs siqrhspspr rkrtpspsyq
      361 rtltpplrrs aspypshsls spqrkqsppr hrspmrekgr hdhertsqsh drrherredt
      421 rgkrdrekds reereyeqdq sssrdhrddr eprdgrdrrd ardtrdrrel rdsrdmrdsr
      481 emrdysrdtk esrdprdsrs trdahdyrdr egrdthrked typeesrsyg rnhlreessr
      541 teirnesrne srseirndrm grsrgrvpel pekgsrgsrg sqidshssns nyhdswetrs
      601 syperdrype rdnrdqards sferrhgerd rrdnrerapm fytsccpypl ppvfsgpagg
      661 tekirdqrps spirhqgrnd elerderree rrvdrvddrr derarerdre rerdrerere
      721 rererdrere kerelerera rererereke rdrerdrdrd hdrererere rdrekerere
      781 reerererer ererererer ererarerdk ererqrdwed kdkgrddrre kreeiredrn
      841 prdghderks kkryrnegsp sprqspkrrr ehspdsdayn sgddknekhr llsqvvrpqe
      901 srslspshlt edrqgrwkee drkperkess rryeeqelke kvssvdkqre qteilessrm
      961 raqdiighhq sedretsdra hdenkkkaki qkkpikkkke ddvgiergni ettsedgqvf
     1021 spkkgqkkks iekkrkkskg dsdisdeeaa qqskkkrgpr tppittkeel vemcngkngi
     1081 ledsqkkedt afsdwsdedv pdrtevteae htatattpgs tpsplssllp ppppvatata
     1141 ttvpatlaat taaaatsfst saitistsat ptnttnntfa nedshrkchr trvekvetph
     1201 vtiedaqhrk pmdqkrsssl gsnrsnrsht sgrlrspsnd sahrsgddqs grkrvlhsgs
     1261 rdrektksle itgerksrid qlkrgepsrs tssdrqdsrs hssrrsspes drqvhsrsgs
     1321 fdsrdrlqer dryehdrere rerrdtrqre wdrdadkdwp rnrdrdrlre rerererdkr
     1381 rdldrererl isdsverdrd rdrdrtfess qiesvkrcea klegeherdl estsrdslal
     1441 dkermdkdlg svqgfeetnk sertesleag ddesklddah slgsgagegy episddelde
     1501 ilagdaekre dqqdeekmpd pldvidvdws glmpkhpkep repgaallkf tpgavmlrvg
     1561 iskklagsel fakvketcqr llekpkdadn lfehelgaln maallrkeer asllsnlgpc
     1621 ckalcfrrds airkqlvkne kgtikqayts apmvdnellr lslrlfkrkt tchapghekt
     1681 ednklsqssi qqelcvs
//
LOCUS       XP_005266363            1697 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger CCCH domain-containing protein 13 isoform X1 [Homo
            sapiens].
ACCESSION   XP_005266363
VERSION     XP_005266363.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266306.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1697
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1697
                     /product="zinc finger CCCH domain-containing protein 13
                     isoform X1"
                     /calculated_mol_wt=199546
     Region          42..63
                     /region_name="zf-CCCH"
                     /note="Zinc finger C-x8-C-x5-C-x3-H type (and similar);
                     pfam00642"
                     /db_xref="CDD:459885"
     Region          343..>566
                     /region_name="PRK12678"
                     /note="transcription termination factor Rho; Provisional"
                     /db_xref="CDD:237171"
     CDS             1..1697
                     /gene="ZC3H13"
                     /gene_synonym="KIAA0853; Xio"
                     /coded_by="XM_005266306.4:56..5149"
                     /db_xref="GeneID:23091"
                     /db_xref="HGNC:HGNC:20368"
                     /db_xref="MIM:616453"
ORIGIN      
        1 mskirrkvtv entktisdst srrpsvferl gpstgstaet qcrnwlktgn clygntcrfv
       61 hgpsprgkgy ssnyrrsper ptgdlrermk nkrqdvdtep qkrnteesss pvrkessrgr
      121 hrekedikit kertpeseee nvewetnrdd sdngdinydy vhelslemkr qkiqrelmkl
      181 eqenmekree iiikkevspe vvrsklspsp slrksskspk rksspksssa skkdrktsav
      241 ssplldqqrn sktnqskkkg prtpsppppi pedialgkky kekykvkdri eektrdgkdr
      301 grdferqrek rdkprstspa gqhhspissr hhssssqsgs siqrhspspr rkrtpspsyq
      361 rtltpplrrs aspypshsls spqrkqsppr hrspmrekgr hdhertsqsh drrherredt
      421 rgkrdrekds reereyeqdq sssrdhrddr eprdgrdrrd ardtrdrrel rdsrdmrdsr
      481 emrdysrdtk esrdprdsrs trdahdyrdr egrdthrked typeesrsyg rnhlreessr
      541 teirnesrne srseirndrm grsrgrvpel pekgsrgsrg sqidshssns nyhdswetrs
      601 syperdrype rdnrdqards sferrhgerd rrdnrerapm fytsccpypl ppvfsgpagg
      661 tekirdqrps spirhqgrnd elerderree rrvdrvddrr derarerdre rerdrerere
      721 rererdrere kerelerera rererereke rdrerdrdrd hdrererere rdrekerere
      781 reerererer ererererer ererarerdk ererqrdwed kdkgrddrre kreeiredrn
      841 prdghderks kkryrnegsp sprqspkrrr ehspdsdayn sgddknekhr llsqvvrpqe
      901 srslspshlt edrqgrwkee drkperkess rryeeqelke kvssvdkqre qteilessrm
      961 raqdiighhq sedretsdra hdenkkkaki qkkpikkkke ddvgiergni ettsedgqvf
     1021 spkkgqkkks iekkrkkskg dsdisdeeaa qqskkkrgpr tppittkeel vemcngkngi
     1081 ledsqkkedt afsdwsdedv pdrtevteae htatattpgs tpsplssllp ppppvatata
     1141 ttvpatlaat taaaatsfst saitistsat ptnttnntfa nedshrkchr trvekvetph
     1201 vtiedaqhrk pmdqkrsssl gsnrsnrsht sgrlrspsnd sahrsgddqs grkrvlhsgs
     1261 rdrektksle itgerksrid qlkrgepsrs tssdrqdsrs hssrrsspes drqvhsrsgs
     1321 fdsrdrlqer dryehdrere rerrdtrqre wdrdadkdwp rnrdrdrlre rerererdkr
     1381 rdldrererl isdsverdrd rdrdrtfess qiesvkrcea klegeherdl estsrdslal
     1441 dkermdkdlg svqgfeetnk sertesleag ddesklddah slgsgagegy episddelde
     1501 ilagdaekre dqqdeekmpd pldvidvdws glmpkhpkep repgaallkf tpgavmlrvg
     1561 iskklagsel fakvketcqr llekpkdadn lfehelgaln maallrkeer asllsnlgpc
     1621 ckalcfrrds airkqlvkne kgtikqayts apmvdnellr lslrlfkrkt tchapghekt
     1681 ednklsqssi qqelcvs
//
LOCUS       XP_016875965            1697 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger CCCH domain-containing protein 13 isoform X1 [Homo
            sapiens].
ACCESSION   XP_016875965
VERSION     XP_016875965.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020476.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1697
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1697
                     /product="zinc finger CCCH domain-containing protein 13
                     isoform X1"
                     /calculated_mol_wt=199546
     Region          42..63
                     /region_name="zf-CCCH"
                     /note="Zinc finger C-x8-C-x5-C-x3-H type (and similar);
                     pfam00642"
                     /db_xref="CDD:459885"
     Region          343..>566
                     /region_name="PRK12678"
                     /note="transcription termination factor Rho; Provisional"
                     /db_xref="CDD:237171"
     CDS             1..1697
                     /gene="ZC3H13"
                     /gene_synonym="KIAA0853; Xio"
                     /coded_by="XM_017020476.3:114..5207"
                     /db_xref="GeneID:23091"
                     /db_xref="HGNC:HGNC:20368"
                     /db_xref="MIM:616453"
ORIGIN      
        1 mskirrkvtv entktisdst srrpsvferl gpstgstaet qcrnwlktgn clygntcrfv
       61 hgpsprgkgy ssnyrrsper ptgdlrermk nkrqdvdtep qkrnteesss pvrkessrgr
      121 hrekedikit kertpeseee nvewetnrdd sdngdinydy vhelslemkr qkiqrelmkl
      181 eqenmekree iiikkevspe vvrsklspsp slrksskspk rksspksssa skkdrktsav
      241 ssplldqqrn sktnqskkkg prtpsppppi pedialgkky kekykvkdri eektrdgkdr
      301 grdferqrek rdkprstspa gqhhspissr hhssssqsgs siqrhspspr rkrtpspsyq
      361 rtltpplrrs aspypshsls spqrkqsppr hrspmrekgr hdhertsqsh drrherredt
      421 rgkrdrekds reereyeqdq sssrdhrddr eprdgrdrrd ardtrdrrel rdsrdmrdsr
      481 emrdysrdtk esrdprdsrs trdahdyrdr egrdthrked typeesrsyg rnhlreessr
      541 teirnesrne srseirndrm grsrgrvpel pekgsrgsrg sqidshssns nyhdswetrs
      601 syperdrype rdnrdqards sferrhgerd rrdnrerapm fytsccpypl ppvfsgpagg
      661 tekirdqrps spirhqgrnd elerderree rrvdrvddrr derarerdre rerdrerere
      721 rererdrere kerelerera rererereke rdrerdrdrd hdrererere rdrekerere
      781 reerererer ererererer ererarerdk ererqrdwed kdkgrddrre kreeiredrn
      841 prdghderks kkryrnegsp sprqspkrrr ehspdsdayn sgddknekhr llsqvvrpqe
      901 srslspshlt edrqgrwkee drkperkess rryeeqelke kvssvdkqre qteilessrm
      961 raqdiighhq sedretsdra hdenkkkaki qkkpikkkke ddvgiergni ettsedgqvf
     1021 spkkgqkkks iekkrkkskg dsdisdeeaa qqskkkrgpr tppittkeel vemcngkngi
     1081 ledsqkkedt afsdwsdedv pdrtevteae htatattpgs tpsplssllp ppppvatata
     1141 ttvpatlaat taaaatsfst saitistsat ptnttnntfa nedshrkchr trvekvetph
     1201 vtiedaqhrk pmdqkrsssl gsnrsnrsht sgrlrspsnd sahrsgddqs grkrvlhsgs
     1261 rdrektksle itgerksrid qlkrgepsrs tssdrqdsrs hssrrsspes drqvhsrsgs
     1321 fdsrdrlqer dryehdrere rerrdtrqre wdrdadkdwp rnrdrdrlre rerererdkr
     1381 rdldrererl isdsverdrd rdrdrtfess qiesvkrcea klegeherdl estsrdslal
     1441 dkermdkdlg svqgfeetnk sertesleag ddesklddah slgsgagegy episddelde
     1501 ilagdaekre dqqdeekmpd pldvidvdws glmpkhpkep repgaallkf tpgavmlrvg
     1561 iskklagsel fakvketcqr llekpkdadn lfehelgaln maallrkeer asllsnlgpc
     1621 ckalcfrrds airkqlvkne kgtikqayts apmvdnellr lslrlfkrkt tchapghekt
     1681 ednklsqssi qqelcvs
//
LOCUS       XP_005266360            1697 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger CCCH domain-containing protein 13 isoform X1 [Homo
            sapiens].
ACCESSION   XP_005266360
VERSION     XP_005266360.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266303.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1697
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1697
                     /product="zinc finger CCCH domain-containing protein 13
                     isoform X1"
                     /calculated_mol_wt=199546
     Region          42..63
                     /region_name="zf-CCCH"
                     /note="Zinc finger C-x8-C-x5-C-x3-H type (and similar);
                     pfam00642"
                     /db_xref="CDD:459885"
     Region          343..>566
                     /region_name="PRK12678"
                     /note="transcription termination factor Rho; Provisional"
                     /db_xref="CDD:237171"
     CDS             1..1697
                     /gene="ZC3H13"
                     /gene_synonym="KIAA0853; Xio"
                     /coded_by="XM_005266303.4:411..5504"
                     /db_xref="GeneID:23091"
                     /db_xref="HGNC:HGNC:20368"
                     /db_xref="MIM:616453"
ORIGIN      
        1 mskirrkvtv entktisdst srrpsvferl gpstgstaet qcrnwlktgn clygntcrfv
       61 hgpsprgkgy ssnyrrsper ptgdlrermk nkrqdvdtep qkrnteesss pvrkessrgr
      121 hrekedikit kertpeseee nvewetnrdd sdngdinydy vhelslemkr qkiqrelmkl
      181 eqenmekree iiikkevspe vvrsklspsp slrksskspk rksspksssa skkdrktsav
      241 ssplldqqrn sktnqskkkg prtpsppppi pedialgkky kekykvkdri eektrdgkdr
      301 grdferqrek rdkprstspa gqhhspissr hhssssqsgs siqrhspspr rkrtpspsyq
      361 rtltpplrrs aspypshsls spqrkqsppr hrspmrekgr hdhertsqsh drrherredt
      421 rgkrdrekds reereyeqdq sssrdhrddr eprdgrdrrd ardtrdrrel rdsrdmrdsr
      481 emrdysrdtk esrdprdsrs trdahdyrdr egrdthrked typeesrsyg rnhlreessr
      541 teirnesrne srseirndrm grsrgrvpel pekgsrgsrg sqidshssns nyhdswetrs
      601 syperdrype rdnrdqards sferrhgerd rrdnrerapm fytsccpypl ppvfsgpagg
      661 tekirdqrps spirhqgrnd elerderree rrvdrvddrr derarerdre rerdrerere
      721 rererdrere kerelerera rererereke rdrerdrdrd hdrererere rdrekerere
      781 reerererer ererererer ererarerdk ererqrdwed kdkgrddrre kreeiredrn
      841 prdghderks kkryrnegsp sprqspkrrr ehspdsdayn sgddknekhr llsqvvrpqe
      901 srslspshlt edrqgrwkee drkperkess rryeeqelke kvssvdkqre qteilessrm
      961 raqdiighhq sedretsdra hdenkkkaki qkkpikkkke ddvgiergni ettsedgqvf
     1021 spkkgqkkks iekkrkkskg dsdisdeeaa qqskkkrgpr tppittkeel vemcngkngi
     1081 ledsqkkedt afsdwsdedv pdrtevteae htatattpgs tpsplssllp ppppvatata
     1141 ttvpatlaat taaaatsfst saitistsat ptnttnntfa nedshrkchr trvekvetph
     1201 vtiedaqhrk pmdqkrsssl gsnrsnrsht sgrlrspsnd sahrsgddqs grkrvlhsgs
     1261 rdrektksle itgerksrid qlkrgepsrs tssdrqdsrs hssrrsspes drqvhsrsgs
     1321 fdsrdrlqer dryehdrere rerrdtrqre wdrdadkdwp rnrdrdrlre rerererdkr
     1381 rdldrererl isdsverdrd rdrdrtfess qiesvkrcea klegeherdl estsrdslal
     1441 dkermdkdlg svqgfeetnk sertesleag ddesklddah slgsgagegy episddelde
     1501 ilagdaekre dqqdeekmpd pldvidvdws glmpkhpkep repgaallkf tpgavmlrvg
     1561 iskklagsel fakvketcqr llekpkdadn lfehelgaln maallrkeer asllsnlgpc
     1621 ckalcfrrds airkqlvkne kgtikqayts apmvdnellr lslrlfkrkt tchapghekt
     1681 ednklsqssi qqelcvs
//
LOCUS       XP_016875964            1697 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger CCCH domain-containing protein 13 isoform X1 [Homo
            sapiens].
ACCESSION   XP_016875964
VERSION     XP_016875964.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020475.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1697
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1697
                     /product="zinc finger CCCH domain-containing protein 13
                     isoform X1"
                     /calculated_mol_wt=199546
     Region          42..63
                     /region_name="zf-CCCH"
                     /note="Zinc finger C-x8-C-x5-C-x3-H type (and similar);
                     pfam00642"
                     /db_xref="CDD:459885"
     Region          343..>566
                     /region_name="PRK12678"
                     /note="transcription termination factor Rho; Provisional"
                     /db_xref="CDD:237171"
     CDS             1..1697
                     /gene="ZC3H13"
                     /gene_synonym="KIAA0853; Xio"
                     /coded_by="XM_017020475.3:117..5210"
                     /db_xref="GeneID:23091"
                     /db_xref="HGNC:HGNC:20368"
                     /db_xref="MIM:616453"
ORIGIN      
        1 mskirrkvtv entktisdst srrpsvferl gpstgstaet qcrnwlktgn clygntcrfv
       61 hgpsprgkgy ssnyrrsper ptgdlrermk nkrqdvdtep qkrnteesss pvrkessrgr
      121 hrekedikit kertpeseee nvewetnrdd sdngdinydy vhelslemkr qkiqrelmkl
      181 eqenmekree iiikkevspe vvrsklspsp slrksskspk rksspksssa skkdrktsav
      241 ssplldqqrn sktnqskkkg prtpsppppi pedialgkky kekykvkdri eektrdgkdr
      301 grdferqrek rdkprstspa gqhhspissr hhssssqsgs siqrhspspr rkrtpspsyq
      361 rtltpplrrs aspypshsls spqrkqsppr hrspmrekgr hdhertsqsh drrherredt
      421 rgkrdrekds reereyeqdq sssrdhrddr eprdgrdrrd ardtrdrrel rdsrdmrdsr
      481 emrdysrdtk esrdprdsrs trdahdyrdr egrdthrked typeesrsyg rnhlreessr
      541 teirnesrne srseirndrm grsrgrvpel pekgsrgsrg sqidshssns nyhdswetrs
      601 syperdrype rdnrdqards sferrhgerd rrdnrerapm fytsccpypl ppvfsgpagg
      661 tekirdqrps spirhqgrnd elerderree rrvdrvddrr derarerdre rerdrerere
      721 rererdrere kerelerera rererereke rdrerdrdrd hdrererere rdrekerere
      781 reerererer ererererer ererarerdk ererqrdwed kdkgrddrre kreeiredrn
      841 prdghderks kkryrnegsp sprqspkrrr ehspdsdayn sgddknekhr llsqvvrpqe
      901 srslspshlt edrqgrwkee drkperkess rryeeqelke kvssvdkqre qteilessrm
      961 raqdiighhq sedretsdra hdenkkkaki qkkpikkkke ddvgiergni ettsedgqvf
     1021 spkkgqkkks iekkrkkskg dsdisdeeaa qqskkkrgpr tppittkeel vemcngkngi
     1081 ledsqkkedt afsdwsdedv pdrtevteae htatattpgs tpsplssllp ppppvatata
     1141 ttvpatlaat taaaatsfst saitistsat ptnttnntfa nedshrkchr trvekvetph
     1201 vtiedaqhrk pmdqkrsssl gsnrsnrsht sgrlrspsnd sahrsgddqs grkrvlhsgs
     1261 rdrektksle itgerksrid qlkrgepsrs tssdrqdsrs hssrrsspes drqvhsrsgs
     1321 fdsrdrlqer dryehdrere rerrdtrqre wdrdadkdwp rnrdrdrlre rerererdkr
     1381 rdldrererl isdsverdrd rdrdrtfess qiesvkrcea klegeherdl estsrdslal
     1441 dkermdkdlg svqgfeetnk sertesleag ddesklddah slgsgagegy episddelde
     1501 ilagdaekre dqqdeekmpd pldvidvdws glmpkhpkep repgaallkf tpgavmlrvg
     1561 iskklagsel fakvketcqr llekpkdadn lfehelgaln maallrkeer asllsnlgpc
     1621 ckalcfrrds airkqlvkne kgtikqayts apmvdnellr lslrlfkrkt tchapghekt
     1681 ednklsqssi qqelcvs
//
LOCUS       XP_047286161            1696 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger CCCH domain-containing protein 13 isoform X2 [Homo
            sapiens].
ACCESSION   XP_047286161
VERSION     XP_047286161.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430205.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1696
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1696
                     /product="zinc finger CCCH domain-containing protein 13
                     isoform X2"
                     /calculated_mol_wt=199475
     Region          42..63
                     /region_name="zf-CCCH"
                     /note="Zinc finger C-x8-C-x5-C-x3-H type (and similar);
                     pfam00642"
                     /db_xref="CDD:459885"
     Region          343..>566
                     /region_name="PRK12678"
                     /note="transcription termination factor Rho; Provisional"
                     /db_xref="CDD:237171"
     CDS             1..1696
                     /gene="ZC3H13"
                     /gene_synonym="KIAA0853; Xio"
                     /coded_by="XM_047430205.1:350..5440"
                     /db_xref="GeneID:23091"
                     /db_xref="HGNC:HGNC:20368"
                     /db_xref="MIM:616453"
ORIGIN      
        1 mskirrkvtv entktisdst srrpsvferl gpstgstaet qcrnwlktgn clygntcrfv
       61 hgpsprgkgy ssnyrrsper ptgdlrermk nkrqdvdtep qkrnteesss pvrkessrgr
      121 hrekedikit kertpeseee nvewetnrdd sdngdinydy vhelslemkr qkiqrelmkl
      181 eqenmekree iiikkevspe vvrsklspsp slrksskspk rksspksssa skkdrktsav
      241 ssplldqqrn sktnqskkkg prtpsppppi pedialgkky kekykvkdri eektrdgkdr
      301 grdferqrek rdkprstspa gqhhspissr hhssssqsgs siqrhspspr rkrtpspsyq
      361 rtltpplrrs aspypshsls spqrkqsppr hrspmrekgr hdhertsqsh drrherredt
      421 rgkrdrekds reereyeqdq sssrdhrddr eprdgrdrrd ardtrdrrel rdsrdmrdsr
      481 emrdysrdtk esrdprdsrs trdahdyrdr egrdthrked typeesrsyg rnhlreessr
      541 teirnesrne srseirndrm grsrgrvpel pekgsrgsrg sqidshssns nyhdswetrs
      601 syperdrype rdnrdqards sferrhgerd rrdnrerapm fytsccpypl ppvfsgpagg
      661 tekirdqrps spirhqgrnd elerderree rrvdrvddrr derarerdre rerdrerere
      721 rererdrere kerelerera rererereke rdrerdrdrd hdrererere rdrekerere
      781 reerererer ererererer ererarerdk ererqrdwed kdkgrddrre kreeiredrn
      841 prdghderks kkryrnegsp sprqspkrrr ehspdsdayn sgddknekhr llsqvvrpqe
      901 srslspshlt edrqgrwkee drkperkess rryeeqelke kvssvdkqre qteilessrm
      961 raqdiighhq sedretsdra hdenkkkaki qkkpikkkke ddvgiergni ettsedgqvf
     1021 spkkgqkkks iekkrkkskg dsdisdeeaa qqskkkrgpr tppittkeel vemcngkngi
     1081 ledsqkkedt afsdwsdedv pdrtevteae htatattpgs tpsplssllp ppppvatata
     1141 ttvpatlaat taaaatsfst saitistsat ptnttnntfa nedshrkchr trvekvetph
     1201 vtiedaqhrk pmdqkrsssl gsnrsnrsht sgrlrspsnd sahrsgddqs grkrvlhsgs
     1261 rdrektksle itgerksrid qlkrgepsrs tssdrqdsrs hssrrsspes drqvhsrsgs
     1321 fdsrdrlqer dryehdrere rerrdtrqre wdrdadkdwp rnrdrdrlre rerererdkr
     1381 rdldrererl isdsverdrd rdrdrtfess qiesvkrcea klegeherdl estsrdslal
     1441 dkermdkdlg svqgfeetnk serteslegd desklddahs lgsgagegye pisddeldei
     1501 lagdaekred qqdeekmpdp ldvidvdwsg lmpkhpkepr epgaallkft pgavmlrvgi
     1561 skklagself akvketcqrl lekpkdadnl fehelgalnm aallrkeera sllsnlgpcc
     1621 kalcfrrdsa irkqlvknek gtikqaytsa pmvdnellrl slrlfkrktt chapghekte
     1681 dnklsqssiq qelcvs
//
LOCUS       XP_016875967            1669 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger CCCH domain-containing protein 13 isoform X3 [Homo
            sapiens].
ACCESSION   XP_016875967
VERSION     XP_016875967.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020478.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1669
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1669
                     /product="zinc finger CCCH domain-containing protein 13
                     isoform X3"
                     /calculated_mol_wt=196576
     Region          42..63
                     /region_name="zf-CCCH"
                     /note="Zinc finger C-x8-C-x5-C-x3-H type (and similar);
                     pfam00642"
                     /db_xref="CDD:459885"
     Region          343..>566
                     /region_name="PRK12678"
                     /note="transcription termination factor Rho; Provisional"
                     /db_xref="CDD:237171"
     CDS             1..1669
                     /gene="ZC3H13"
                     /gene_synonym="KIAA0853; Xio"
                     /coded_by="XM_017020478.2:408..5417"
                     /db_xref="GeneID:23091"
                     /db_xref="HGNC:HGNC:20368"
                     /db_xref="MIM:616453"
ORIGIN      
        1 mskirrkvtv entktisdst srrpsvferl gpstgstaet qcrnwlktgn clygntcrfv
       61 hgpsprgkgy ssnyrrsper ptgdlrermk nkrqdvdtep qkrnteesss pvrkessrgr
      121 hrekedikit kertpeseee nvewetnrdd sdngdinydy vhelslemkr qkiqrelmkl
      181 eqenmekree iiikkevspe vvrsklspsp slrksskspk rksspksssa skkdrktsav
      241 ssplldqqrn sktnqskkkg prtpsppppi pedialgkky kekykvkdri eektrdgkdr
      301 grdferqrek rdkprstspa gqhhspissr hhssssqsgs siqrhspspr rkrtpspsyq
      361 rtltpplrrs aspypshsls spqrkqsppr hrspmrekgr hdhertsqsh drrherredt
      421 rgkrdrekds reereyeqdq sssrdhrddr eprdgrdrrd ardtrdrrel rdsrdmrdsr
      481 emrdysrdtk esrdprdsrs trdahdyrdr egrdthrked typeesrsyg rnhlreessr
      541 teirnesrne srseirndrm grsrgrvpel pekgsrgsrg sqidshssns nyhdswetrs
      601 syperdrype rdnrdqards sferrhgerd rrdnrerdqr psspirhqgr ndelerderr
      661 eerrvdrvdd rrderarerd rererdrere rerererdre rekerelere rarererere
      721 kerdrerdrd rdhdrerere rerdrekere rereererer ererererer erererarer
      781 dkererqrdw edkdkgrddr rekreeired rnprdghder kskkryrneg spsprqspkr
      841 rrehspdsda ynsgddknek hrllsqvvrp qesrslspsh ltedrqgrwk eedrkperke
      901 ssrryeeqel kekvssvdkq reqteiless rmraqdiigh hqsedretsd rahdenkkka
      961 kiqkkpikkk keddvgierg niettsedgq vfspkkgqkk ksiekkrkks kgdsdisdee
     1021 aaqqskkkrg prtppittke elvemcngkn giledsqkke dtafsdwsde dvpdrtevte
     1081 aehtatattp gstpsplssl lpppppvata tattvpatla attaaaatsf stsaitists
     1141 atptnttnnt fanedshrkc hrtrvekvet phvtiedaqh rkpmdqkrss slgsnrsnrs
     1201 htsgrlrsps ndsahrsgdd qsgrkrvlhs gsrdrektks leitgerksr idqlkrgeps
     1261 rstssdrqds rshssrrssp esdrqvhsrs gsfdsrdrlq erdryehdre rererrdtrq
     1321 rewdrdadkd wprnrdrdrl rererererd krrdldrere rlisdsverd rdrdrdrtfe
     1381 ssqiesvkrc eaklegeher dlestsrdsl aldkermdkd lgsvqgfeet nksertesle
     1441 agddeskldd ahslgsgage gyepisddel deilagdaek redqqdeekm pdpldvidvd
     1501 wsglmpkhpk eprepgaall kftpgavmlr vgiskklags elfakvketc qrllekpkda
     1561 dnlfehelga lnmaallrke erasllsnlg pcckalcfrr dsairkqlvk nekgtikqay
     1621 tsapmvdnel lrlslrlfkr kttchapghe ktednklsqs siqqelcvs
//
LOCUS       XP_047286162            1669 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger CCCH domain-containing protein 13 isoform X3 [Homo
            sapiens].
ACCESSION   XP_047286162
VERSION     XP_047286162.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430206.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1669
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1669
                     /product="zinc finger CCCH domain-containing protein 13
                     isoform X3"
                     /calculated_mol_wt=196576
     Region          42..63
                     /region_name="zf-CCCH"
                     /note="Zinc finger C-x8-C-x5-C-x3-H type (and similar);
                     pfam00642"
                     /db_xref="CDD:459885"
     Region          343..>566
                     /region_name="PRK12678"
                     /note="transcription termination factor Rho; Provisional"
                     /db_xref="CDD:237171"
     CDS             1..1669
                     /gene="ZC3H13"
                     /gene_synonym="KIAA0853; Xio"
                     /coded_by="XM_047430206.1:114..5123"
                     /db_xref="GeneID:23091"
                     /db_xref="HGNC:HGNC:20368"
                     /db_xref="MIM:616453"
ORIGIN      
        1 mskirrkvtv entktisdst srrpsvferl gpstgstaet qcrnwlktgn clygntcrfv
       61 hgpsprgkgy ssnyrrsper ptgdlrermk nkrqdvdtep qkrnteesss pvrkessrgr
      121 hrekedikit kertpeseee nvewetnrdd sdngdinydy vhelslemkr qkiqrelmkl
      181 eqenmekree iiikkevspe vvrsklspsp slrksskspk rksspksssa skkdrktsav
      241 ssplldqqrn sktnqskkkg prtpsppppi pedialgkky kekykvkdri eektrdgkdr
      301 grdferqrek rdkprstspa gqhhspissr hhssssqsgs siqrhspspr rkrtpspsyq
      361 rtltpplrrs aspypshsls spqrkqsppr hrspmrekgr hdhertsqsh drrherredt
      421 rgkrdrekds reereyeqdq sssrdhrddr eprdgrdrrd ardtrdrrel rdsrdmrdsr
      481 emrdysrdtk esrdprdsrs trdahdyrdr egrdthrked typeesrsyg rnhlreessr
      541 teirnesrne srseirndrm grsrgrvpel pekgsrgsrg sqidshssns nyhdswetrs
      601 syperdrype rdnrdqards sferrhgerd rrdnrerdqr psspirhqgr ndelerderr
      661 eerrvdrvdd rrderarerd rererdrere rerererdre rekerelere rarererere
      721 kerdrerdrd rdhdrerere rerdrekere rereererer ererererer erererarer
      781 dkererqrdw edkdkgrddr rekreeired rnprdghder kskkryrneg spsprqspkr
      841 rrehspdsda ynsgddknek hrllsqvvrp qesrslspsh ltedrqgrwk eedrkperke
      901 ssrryeeqel kekvssvdkq reqteiless rmraqdiigh hqsedretsd rahdenkkka
      961 kiqkkpikkk keddvgierg niettsedgq vfspkkgqkk ksiekkrkks kgdsdisdee
     1021 aaqqskkkrg prtppittke elvemcngkn giledsqkke dtafsdwsde dvpdrtevte
     1081 aehtatattp gstpsplssl lpppppvata tattvpatla attaaaatsf stsaitists
     1141 atptnttnnt fanedshrkc hrtrvekvet phvtiedaqh rkpmdqkrss slgsnrsnrs
     1201 htsgrlrsps ndsahrsgdd qsgrkrvlhs gsrdrektks leitgerksr idqlkrgeps
     1261 rstssdrqds rshssrrssp esdrqvhsrs gsfdsrdrlq erdryehdre rererrdtrq
     1321 rewdrdadkd wprnrdrdrl rererererd krrdldrere rlisdsverd rdrdrdrtfe
     1381 ssqiesvkrc eaklegeher dlestsrdsl aldkermdkd lgsvqgfeet nksertesle
     1441 agddeskldd ahslgsgage gyepisddel deilagdaek redqqdeekm pdpldvidvd
     1501 wsglmpkhpk eprepgaall kftpgavmlr vgiskklags elfakvketc qrllekpkda
     1561 dnlfehelga lnmaallrke erasllsnlg pcckalcfrr dsairkqlvk nekgtikqay
     1621 tsapmvdnel lrlslrlfkr kttchapghe ktednklsqs siqqelcvs
//
LOCUS       XP_047286163            1668 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger CCCH domain-containing protein 13 isoform X4 [Homo
            sapiens].
ACCESSION   XP_047286163
VERSION     XP_047286163.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430207.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1668
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1668
                     /product="zinc finger CCCH domain-containing protein 13
                     isoform X4"
                     /calculated_mol_wt=196505
     Region          42..63
                     /region_name="zf-CCCH"
                     /note="Zinc finger C-x8-C-x5-C-x3-H type (and similar);
                     pfam00642"
                     /db_xref="CDD:459885"
     Region          343..>566
                     /region_name="PRK12678"
                     /note="transcription termination factor Rho; Provisional"
                     /db_xref="CDD:237171"
     CDS             1..1668
                     /gene="ZC3H13"
                     /gene_synonym="KIAA0853; Xio"
                     /coded_by="XM_047430207.1:56..5062"
                     /db_xref="GeneID:23091"
                     /db_xref="HGNC:HGNC:20368"
                     /db_xref="MIM:616453"
ORIGIN      
        1 mskirrkvtv entktisdst srrpsvferl gpstgstaet qcrnwlktgn clygntcrfv
       61 hgpsprgkgy ssnyrrsper ptgdlrermk nkrqdvdtep qkrnteesss pvrkessrgr
      121 hrekedikit kertpeseee nvewetnrdd sdngdinydy vhelslemkr qkiqrelmkl
      181 eqenmekree iiikkevspe vvrsklspsp slrksskspk rksspksssa skkdrktsav
      241 ssplldqqrn sktnqskkkg prtpsppppi pedialgkky kekykvkdri eektrdgkdr
      301 grdferqrek rdkprstspa gqhhspissr hhssssqsgs siqrhspspr rkrtpspsyq
      361 rtltpplrrs aspypshsls spqrkqsppr hrspmrekgr hdhertsqsh drrherredt
      421 rgkrdrekds reereyeqdq sssrdhrddr eprdgrdrrd ardtrdrrel rdsrdmrdsr
      481 emrdysrdtk esrdprdsrs trdahdyrdr egrdthrked typeesrsyg rnhlreessr
      541 teirnesrne srseirndrm grsrgrvpel pekgsrgsrg sqidshssns nyhdswetrs
      601 syperdrype rdnrdqards sferrhgerd rrdnrerdqr psspirhqgr ndelerderr
      661 eerrvdrvdd rrderarerd rererdrere rerererdre rekerelere rarererere
      721 kerdrerdrd rdhdrerere rerdrekere rereererer ererererer erererarer
      781 dkererqrdw edkdkgrddr rekreeired rnprdghder kskkryrneg spsprqspkr
      841 rrehspdsda ynsgddknek hrllsqvvrp qesrslspsh ltedrqgrwk eedrkperke
      901 ssrryeeqel kekvssvdkq reqteiless rmraqdiigh hqsedretsd rahdenkkka
      961 kiqkkpikkk keddvgierg niettsedgq vfspkkgqkk ksiekkrkks kgdsdisdee
     1021 aaqqskkkrg prtppittke elvemcngkn giledsqkke dtafsdwsde dvpdrtevte
     1081 aehtatattp gstpsplssl lpppppvata tattvpatla attaaaatsf stsaitists
     1141 atptnttnnt fanedshrkc hrtrvekvet phvtiedaqh rkpmdqkrss slgsnrsnrs
     1201 htsgrlrsps ndsahrsgdd qsgrkrvlhs gsrdrektks leitgerksr idqlkrgeps
     1261 rstssdrqds rshssrrssp esdrqvhsrs gsfdsrdrlq erdryehdre rererrdtrq
     1321 rewdrdadkd wprnrdrdrl rererererd krrdldrere rlisdsverd rdrdrdrtfe
     1381 ssqiesvkrc eaklegeher dlestsrdsl aldkermdkd lgsvqgfeet nksertesle
     1441 gddeskldda hslgsgageg yepisddeld eilagdaekr edqqdeekmp dpldvidvdw
     1501 sglmpkhpke prepgaallk ftpgavmlrv giskklagse lfakvketcq rllekpkdad
     1561 nlfehelgal nmaallrkee rasllsnlgp cckalcfrrd sairkqlvkn ekgtikqayt
     1621 sapmvdnell rlslrlfkrk ttchapghek tednklsqss iqqelcvs
//
LOCUS       XP_047286164            1668 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger CCCH domain-containing protein 13 isoform X4 [Homo
            sapiens].
ACCESSION   XP_047286164
VERSION     XP_047286164.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430208.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1668
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1668
                     /product="zinc finger CCCH domain-containing protein 13
                     isoform X4"
                     /calculated_mol_wt=196505
     Region          42..63
                     /region_name="zf-CCCH"
                     /note="Zinc finger C-x8-C-x5-C-x3-H type (and similar);
                     pfam00642"
                     /db_xref="CDD:459885"
     Region          343..>566
                     /region_name="PRK12678"
                     /note="transcription termination factor Rho; Provisional"
                     /db_xref="CDD:237171"
     CDS             1..1668
                     /gene="ZC3H13"
                     /gene_synonym="KIAA0853; Xio"
                     /coded_by="XM_047430208.1:114..5120"
                     /db_xref="GeneID:23091"
                     /db_xref="HGNC:HGNC:20368"
                     /db_xref="MIM:616453"
ORIGIN      
        1 mskirrkvtv entktisdst srrpsvferl gpstgstaet qcrnwlktgn clygntcrfv
       61 hgpsprgkgy ssnyrrsper ptgdlrermk nkrqdvdtep qkrnteesss pvrkessrgr
      121 hrekedikit kertpeseee nvewetnrdd sdngdinydy vhelslemkr qkiqrelmkl
      181 eqenmekree iiikkevspe vvrsklspsp slrksskspk rksspksssa skkdrktsav
      241 ssplldqqrn sktnqskkkg prtpsppppi pedialgkky kekykvkdri eektrdgkdr
      301 grdferqrek rdkprstspa gqhhspissr hhssssqsgs siqrhspspr rkrtpspsyq
      361 rtltpplrrs aspypshsls spqrkqsppr hrspmrekgr hdhertsqsh drrherredt
      421 rgkrdrekds reereyeqdq sssrdhrddr eprdgrdrrd ardtrdrrel rdsrdmrdsr
      481 emrdysrdtk esrdprdsrs trdahdyrdr egrdthrked typeesrsyg rnhlreessr
      541 teirnesrne srseirndrm grsrgrvpel pekgsrgsrg sqidshssns nyhdswetrs
      601 syperdrype rdnrdqards sferrhgerd rrdnrerdqr psspirhqgr ndelerderr
      661 eerrvdrvdd rrderarerd rererdrere rerererdre rekerelere rarererere
      721 kerdrerdrd rdhdrerere rerdrekere rereererer ererererer erererarer
      781 dkererqrdw edkdkgrddr rekreeired rnprdghder kskkryrneg spsprqspkr
      841 rrehspdsda ynsgddknek hrllsqvvrp qesrslspsh ltedrqgrwk eedrkperke
      901 ssrryeeqel kekvssvdkq reqteiless rmraqdiigh hqsedretsd rahdenkkka
      961 kiqkkpikkk keddvgierg niettsedgq vfspkkgqkk ksiekkrkks kgdsdisdee
     1021 aaqqskkkrg prtppittke elvemcngkn giledsqkke dtafsdwsde dvpdrtevte
     1081 aehtatattp gstpsplssl lpppppvata tattvpatla attaaaatsf stsaitists
     1141 atptnttnnt fanedshrkc hrtrvekvet phvtiedaqh rkpmdqkrss slgsnrsnrs
     1201 htsgrlrsps ndsahrsgdd qsgrkrvlhs gsrdrektks leitgerksr idqlkrgeps
     1261 rstssdrqds rshssrrssp esdrqvhsrs gsfdsrdrlq erdryehdre rererrdtrq
     1321 rewdrdadkd wprnrdrdrl rererererd krrdldrere rlisdsverd rdrdrdrtfe
     1381 ssqiesvkrc eaklegeher dlestsrdsl aldkermdkd lgsvqgfeet nksertesle
     1441 gddeskldda hslgsgageg yepisddeld eilagdaekr edqqdeekmp dpldvidvdw
     1501 sglmpkhpke prepgaallk ftpgavmlrv giskklagse lfakvketcq rllekpkdad
     1561 nlfehelgal nmaallrkee rasllsnlgp cckalcfrrd sairkqlvkn ekgtikqayt
     1621 sapmvdnell rlslrlfkrk ttchapghek tednklsqss iqqelcvs
//
LOCUS       XP_005266371             666 aa            linear   PRI 05-AUG-2025
DEFINITION  spartin isoform X1 [Homo sapiens].
ACCESSION   XP_005266371
VERSION     XP_005266371.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266314.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..666
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..666
                     /product="spartin isoform X1"
                     /calculated_mol_wt=72702
     Region          16..95
                     /region_name="MIT_spastin"
                     /note="MIT: domain contained within Microtubule
                     Interacting and Trafficking molecules. This MIT domain
                     sub-family is found in the AAA protein spastin, a probable
                     ATPase involved in the assembly or function of nuclear
                     protein complexes; spastins might also be...; cd02679"
                     /db_xref="CDD:239142"
     Region          427..617
                     /region_name="Senescence"
                     /note="Senescence domain; pfam06911"
                     /db_xref="CDD:462037"
     CDS             1..666
                     /gene="SPART"
                     /gene_synonym="SPG20; TAHCCP1"
                     /coded_by="XM_005266314.4:238..2238"
                     /db_xref="GeneID:23111"
                     /db_xref="HGNC:HGNC:18514"
                     /db_xref="MIM:607111"
ORIGIN      
        1 meqepqngep aeikiireay kkaflfvnkg lntdelgqke eaknyykqgi ghllrgisis
       61 skesehtgpg wesarqmqqk mketlqnvrt rleilekgla tslqndlqev pklypefppk
      121 dmceklpepq sfssapqhae vngntstpsa gavaapasls lpsqscpaea ppaytpqaae
      181 ghytvsygtd sgefssvgee fyrnhsqppp letlgldade lilipngvqi ffvnpagevs
      241 apsypgylri vrfldnsldt vlnrppgflq vcdwlyplvp drspvlkcta gaymfpdtml
      301 qaagcfvgvv lsselpeddr elfedllrqm sdlrlqanwn raeeenefqi pgrtrpssdq
      361 lkeasgtdvk qldqgnkdvr hkgkrgkrak dtsseevnls hivpcepvpe ekpkelpews
      421 ekvahnilsg aswvswglvk gaeitgkaiq kgasklreri qpeekpvevs pavtkglyia
      481 kqatggaakv sqflvdgvct vancvgkela phvkkhgskl vpeslkkdkd gkspldgamv
      541 vaassvqgfs tvwqglecaa kcivnnvsae tvqtvrykyg ynageathha vdsavnvgvt
      601 ayninnigik amvkktatqt ghtlledyqi vdnsqrenqe gaanvnvrge kdeqtkevke
      661 akkkdk
//
LOCUS       XP_047286165             666 aa            linear   PRI 05-AUG-2025
DEFINITION  spartin isoform X1 [Homo sapiens].
ACCESSION   XP_047286165
VERSION     XP_047286165.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430209.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..666
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..666
                     /product="spartin isoform X1"
                     /calculated_mol_wt=72702
     Region          16..95
                     /region_name="MIT_spastin"
                     /note="MIT: domain contained within Microtubule
                     Interacting and Trafficking molecules. This MIT domain
                     sub-family is found in the AAA protein spastin, a probable
                     ATPase involved in the assembly or function of nuclear
                     protein complexes; spastins might also be...; cd02679"
                     /db_xref="CDD:239142"
     Region          427..617
                     /region_name="Senescence"
                     /note="Senescence domain; pfam06911"
                     /db_xref="CDD:462037"
     CDS             1..666
                     /gene="SPART"
                     /gene_synonym="SPG20; TAHCCP1"
                     /coded_by="XM_047430209.1:167..2167"
                     /db_xref="GeneID:23111"
                     /db_xref="HGNC:HGNC:18514"
                     /db_xref="MIM:607111"
ORIGIN      
        1 meqepqngep aeikiireay kkaflfvnkg lntdelgqke eaknyykqgi ghllrgisis
       61 skesehtgpg wesarqmqqk mketlqnvrt rleilekgla tslqndlqev pklypefppk
      121 dmceklpepq sfssapqhae vngntstpsa gavaapasls lpsqscpaea ppaytpqaae
      181 ghytvsygtd sgefssvgee fyrnhsqppp letlgldade lilipngvqi ffvnpagevs
      241 apsypgylri vrfldnsldt vlnrppgflq vcdwlyplvp drspvlkcta gaymfpdtml
      301 qaagcfvgvv lsselpeddr elfedllrqm sdlrlqanwn raeeenefqi pgrtrpssdq
      361 lkeasgtdvk qldqgnkdvr hkgkrgkrak dtsseevnls hivpcepvpe ekpkelpews
      421 ekvahnilsg aswvswglvk gaeitgkaiq kgasklreri qpeekpvevs pavtkglyia
      481 kqatggaakv sqflvdgvct vancvgkela phvkkhgskl vpeslkkdkd gkspldgamv
      541 vaassvqgfs tvwqglecaa kcivnnvsae tvqtvrykyg ynageathha vdsavnvgvt
      601 ayninnigik amvkktatqt ghtlledyqi vdnsqrenqe gaanvnvrge kdeqtkevke
      661 akkkdk
//
LOCUS       XP_005266370             666 aa            linear   PRI 05-AUG-2025
DEFINITION  spartin isoform X1 [Homo sapiens].
ACCESSION   XP_005266370
VERSION     XP_005266370.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266313.6
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..666
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..666
                     /product="spartin isoform X1"
                     /calculated_mol_wt=72702
     Region          16..95
                     /region_name="MIT_spastin"
                     /note="MIT: domain contained within Microtubule
                     Interacting and Trafficking molecules. This MIT domain
                     sub-family is found in the AAA protein spastin, a probable
                     ATPase involved in the assembly or function of nuclear
                     protein complexes; spastins might also be...; cd02679"
                     /db_xref="CDD:239142"
     Region          427..617
                     /region_name="Senescence"
                     /note="Senescence domain; pfam06911"
                     /db_xref="CDD:462037"
     CDS             1..666
                     /gene="SPART"
                     /gene_synonym="SPG20; TAHCCP1"
                     /coded_by="XM_005266313.6:158..2158"
                     /db_xref="GeneID:23111"
                     /db_xref="HGNC:HGNC:18514"
                     /db_xref="MIM:607111"
ORIGIN      
        1 meqepqngep aeikiireay kkaflfvnkg lntdelgqke eaknyykqgi ghllrgisis
       61 skesehtgpg wesarqmqqk mketlqnvrt rleilekgla tslqndlqev pklypefppk
      121 dmceklpepq sfssapqhae vngntstpsa gavaapasls lpsqscpaea ppaytpqaae
      181 ghytvsygtd sgefssvgee fyrnhsqppp letlgldade lilipngvqi ffvnpagevs
      241 apsypgylri vrfldnsldt vlnrppgflq vcdwlyplvp drspvlkcta gaymfpdtml
      301 qaagcfvgvv lsselpeddr elfedllrqm sdlrlqanwn raeeenefqi pgrtrpssdq
      361 lkeasgtdvk qldqgnkdvr hkgkrgkrak dtsseevnls hivpcepvpe ekpkelpews
      421 ekvahnilsg aswvswglvk gaeitgkaiq kgasklreri qpeekpvevs pavtkglyia
      481 kqatggaakv sqflvdgvct vancvgkela phvkkhgskl vpeslkkdkd gkspldgamv
      541 vaassvqgfs tvwqglecaa kcivnnvsae tvqtvrykyg ynageathha vdsavnvgvt
      601 ayninnigik amvkktatqt ghtlledyqi vdnsqrenqe gaanvnvrge kdeqtkevke
      661 akkkdk
//
LOCUS       XP_024305102             666 aa            linear   PRI 05-AUG-2025
DEFINITION  spartin isoform X1 [Homo sapiens].
ACCESSION   XP_024305102
VERSION     XP_024305102.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449334.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..666
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..666
                     /product="spartin isoform X1"
                     /calculated_mol_wt=72702
     Region          16..95
                     /region_name="MIT_spastin"
                     /note="MIT: domain contained within Microtubule
                     Interacting and Trafficking molecules. This MIT domain
                     sub-family is found in the AAA protein spastin, a probable
                     ATPase involved in the assembly or function of nuclear
                     protein complexes; spastins might also be...; cd02679"
                     /db_xref="CDD:239142"
     Region          427..617
                     /region_name="Senescence"
                     /note="Senescence domain; pfam06911"
                     /db_xref="CDD:462037"
     CDS             1..666
                     /gene="SPART"
                     /gene_synonym="SPG20; TAHCCP1"
                     /coded_by="XM_024449334.2:245..2245"
                     /db_xref="GeneID:23111"
                     /db_xref="HGNC:HGNC:18514"
                     /db_xref="MIM:607111"
ORIGIN      
        1 meqepqngep aeikiireay kkaflfvnkg lntdelgqke eaknyykqgi ghllrgisis
       61 skesehtgpg wesarqmqqk mketlqnvrt rleilekgla tslqndlqev pklypefppk
      121 dmceklpepq sfssapqhae vngntstpsa gavaapasls lpsqscpaea ppaytpqaae
      181 ghytvsygtd sgefssvgee fyrnhsqppp letlgldade lilipngvqi ffvnpagevs
      241 apsypgylri vrfldnsldt vlnrppgflq vcdwlyplvp drspvlkcta gaymfpdtml
      301 qaagcfvgvv lsselpeddr elfedllrqm sdlrlqanwn raeeenefqi pgrtrpssdq
      361 lkeasgtdvk qldqgnkdvr hkgkrgkrak dtsseevnls hivpcepvpe ekpkelpews
      421 ekvahnilsg aswvswglvk gaeitgkaiq kgasklreri qpeekpvevs pavtkglyia
      481 kqatggaakv sqflvdgvct vancvgkela phvkkhgskl vpeslkkdkd gkspldgamv
      541 vaassvqgfs tvwqglecaa kcivnnvsae tvqtvrykyg ynageathha vdsavnvgvt
      601 ayninnigik amvkktatqt ghtlledyqi vdnsqrenqe gaanvnvrge kdeqtkevke
      661 akkkdk
//
LOCUS       XP_047286166             666 aa            linear   PRI 05-AUG-2025
DEFINITION  spartin isoform X1 [Homo sapiens].
ACCESSION   XP_047286166
VERSION     XP_047286166.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430210.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..666
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..666
                     /product="spartin isoform X1"
                     /calculated_mol_wt=72702
     Region          16..95
                     /region_name="MIT_spastin"
                     /note="MIT: domain contained within Microtubule
                     Interacting and Trafficking molecules. This MIT domain
                     sub-family is found in the AAA protein spastin, a probable
                     ATPase involved in the assembly or function of nuclear
                     protein complexes; spastins might also be...; cd02679"
                     /db_xref="CDD:239142"
     Region          427..617
                     /region_name="Senescence"
                     /note="Senescence domain; pfam06911"
                     /db_xref="CDD:462037"
     CDS             1..666
                     /gene="SPART"
                     /gene_synonym="SPG20; TAHCCP1"
                     /coded_by="XM_047430210.1:408..2408"
                     /db_xref="GeneID:23111"
                     /db_xref="HGNC:HGNC:18514"
                     /db_xref="MIM:607111"
ORIGIN      
        1 meqepqngep aeikiireay kkaflfvnkg lntdelgqke eaknyykqgi ghllrgisis
       61 skesehtgpg wesarqmqqk mketlqnvrt rleilekgla tslqndlqev pklypefppk
      121 dmceklpepq sfssapqhae vngntstpsa gavaapasls lpsqscpaea ppaytpqaae
      181 ghytvsygtd sgefssvgee fyrnhsqppp letlgldade lilipngvqi ffvnpagevs
      241 apsypgylri vrfldnsldt vlnrppgflq vcdwlyplvp drspvlkcta gaymfpdtml
      301 qaagcfvgvv lsselpeddr elfedllrqm sdlrlqanwn raeeenefqi pgrtrpssdq
      361 lkeasgtdvk qldqgnkdvr hkgkrgkrak dtsseevnls hivpcepvpe ekpkelpews
      421 ekvahnilsg aswvswglvk gaeitgkaiq kgasklreri qpeekpvevs pavtkglyia
      481 kqatggaakv sqflvdgvct vancvgkela phvkkhgskl vpeslkkdkd gkspldgamv
      541 vaassvqgfs tvwqglecaa kcivnnvsae tvqtvrykyg ynageathha vdsavnvgvt
      601 ayninnigik amvkktatqt ghtlledyqi vdnsqrenqe gaanvnvrge kdeqtkevke
      661 akkkdk
//
LOCUS       XP_011533314             666 aa            linear   PRI 05-AUG-2025
DEFINITION  spartin isoform X1 [Homo sapiens].
ACCESSION   XP_011533314
VERSION     XP_011533314.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535012.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..666
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..666
                     /product="spartin isoform X1"
                     /calculated_mol_wt=72702
     Region          16..95
                     /region_name="MIT_spastin"
                     /note="MIT: domain contained within Microtubule
                     Interacting and Trafficking molecules. This MIT domain
                     sub-family is found in the AAA protein spastin, a probable
                     ATPase involved in the assembly or function of nuclear
                     protein complexes; spastins might also be...; cd02679"
                     /db_xref="CDD:239142"
     Region          427..617
                     /region_name="Senescence"
                     /note="Senescence domain; pfam06911"
                     /db_xref="CDD:462037"
     CDS             1..666
                     /gene="SPART"
                     /gene_synonym="SPG20; TAHCCP1"
                     /coded_by="XM_011535012.3:84..2084"
                     /db_xref="GeneID:23111"
                     /db_xref="HGNC:HGNC:18514"
                     /db_xref="MIM:607111"
ORIGIN      
        1 meqepqngep aeikiireay kkaflfvnkg lntdelgqke eaknyykqgi ghllrgisis
       61 skesehtgpg wesarqmqqk mketlqnvrt rleilekgla tslqndlqev pklypefppk
      121 dmceklpepq sfssapqhae vngntstpsa gavaapasls lpsqscpaea ppaytpqaae
      181 ghytvsygtd sgefssvgee fyrnhsqppp letlgldade lilipngvqi ffvnpagevs
      241 apsypgylri vrfldnsldt vlnrppgflq vcdwlyplvp drspvlkcta gaymfpdtml
      301 qaagcfvgvv lsselpeddr elfedllrqm sdlrlqanwn raeeenefqi pgrtrpssdq
      361 lkeasgtdvk qldqgnkdvr hkgkrgkrak dtsseevnls hivpcepvpe ekpkelpews
      421 ekvahnilsg aswvswglvk gaeitgkaiq kgasklreri qpeekpvevs pavtkglyia
      481 kqatggaakv sqflvdgvct vancvgkela phvkkhgskl vpeslkkdkd gkspldgamv
      541 vaassvqgfs tvwqglecaa kcivnnvsae tvqtvrykyg ynageathha vdsavnvgvt
      601 ayninnigik amvkktatqt ghtlledyqi vdnsqrenqe gaanvnvrge kdeqtkevke
      661 akkkdk
//
LOCUS       XP_005266372             666 aa            linear   PRI 05-AUG-2025
DEFINITION  spartin isoform X1 [Homo sapiens].
ACCESSION   XP_005266372
VERSION     XP_005266372.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266315.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..666
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..666
                     /product="spartin isoform X1"
                     /calculated_mol_wt=72702
     Region          16..95
                     /region_name="MIT_spastin"
                     /note="MIT: domain contained within Microtubule
                     Interacting and Trafficking molecules. This MIT domain
                     sub-family is found in the AAA protein spastin, a probable
                     ATPase involved in the assembly or function of nuclear
                     protein complexes; spastins might also be...; cd02679"
                     /db_xref="CDD:239142"
     Region          427..617
                     /region_name="Senescence"
                     /note="Senescence domain; pfam06911"
                     /db_xref="CDD:462037"
     CDS             1..666
                     /gene="SPART"
                     /gene_synonym="SPG20; TAHCCP1"
                     /coded_by="XM_005266315.4:125..2125"
                     /db_xref="GeneID:23111"
                     /db_xref="HGNC:HGNC:18514"
                     /db_xref="MIM:607111"
ORIGIN      
        1 meqepqngep aeikiireay kkaflfvnkg lntdelgqke eaknyykqgi ghllrgisis
       61 skesehtgpg wesarqmqqk mketlqnvrt rleilekgla tslqndlqev pklypefppk
      121 dmceklpepq sfssapqhae vngntstpsa gavaapasls lpsqscpaea ppaytpqaae
      181 ghytvsygtd sgefssvgee fyrnhsqppp letlgldade lilipngvqi ffvnpagevs
      241 apsypgylri vrfldnsldt vlnrppgflq vcdwlyplvp drspvlkcta gaymfpdtml
      301 qaagcfvgvv lsselpeddr elfedllrqm sdlrlqanwn raeeenefqi pgrtrpssdq
      361 lkeasgtdvk qldqgnkdvr hkgkrgkrak dtsseevnls hivpcepvpe ekpkelpews
      421 ekvahnilsg aswvswglvk gaeitgkaiq kgasklreri qpeekpvevs pavtkglyia
      481 kqatggaakv sqflvdgvct vancvgkela phvkkhgskl vpeslkkdkd gkspldgamv
      541 vaassvqgfs tvwqglecaa kcivnnvsae tvqtvrykyg ynageathha vdsavnvgvt
      601 ayninnigik amvkktatqt ghtlledyqi vdnsqrenqe gaanvnvrge kdeqtkevke
      661 akkkdk
//
LOCUS       XP_047286167             666 aa            linear   PRI 05-AUG-2025
DEFINITION  spartin isoform X1 [Homo sapiens].
ACCESSION   XP_047286167
VERSION     XP_047286167.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430211.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..666
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..666
                     /product="spartin isoform X1"
                     /calculated_mol_wt=72702
     Region          16..95
                     /region_name="MIT_spastin"
                     /note="MIT: domain contained within Microtubule
                     Interacting and Trafficking molecules. This MIT domain
                     sub-family is found in the AAA protein spastin, a probable
                     ATPase involved in the assembly or function of nuclear
                     protein complexes; spastins might also be...; cd02679"
                     /db_xref="CDD:239142"
     Region          427..617
                     /region_name="Senescence"
                     /note="Senescence domain; pfam06911"
                     /db_xref="CDD:462037"
     CDS             1..666
                     /gene="SPART"
                     /gene_synonym="SPG20; TAHCCP1"
                     /coded_by="XM_047430211.1:300..2300"
                     /db_xref="GeneID:23111"
                     /db_xref="HGNC:HGNC:18514"
                     /db_xref="MIM:607111"
ORIGIN      
        1 meqepqngep aeikiireay kkaflfvnkg lntdelgqke eaknyykqgi ghllrgisis
       61 skesehtgpg wesarqmqqk mketlqnvrt rleilekgla tslqndlqev pklypefppk
      121 dmceklpepq sfssapqhae vngntstpsa gavaapasls lpsqscpaea ppaytpqaae
      181 ghytvsygtd sgefssvgee fyrnhsqppp letlgldade lilipngvqi ffvnpagevs
      241 apsypgylri vrfldnsldt vlnrppgflq vcdwlyplvp drspvlkcta gaymfpdtml
      301 qaagcfvgvv lsselpeddr elfedllrqm sdlrlqanwn raeeenefqi pgrtrpssdq
      361 lkeasgtdvk qldqgnkdvr hkgkrgkrak dtsseevnls hivpcepvpe ekpkelpews
      421 ekvahnilsg aswvswglvk gaeitgkaiq kgasklreri qpeekpvevs pavtkglyia
      481 kqatggaakv sqflvdgvct vancvgkela phvkkhgskl vpeslkkdkd gkspldgamv
      541 vaassvqgfs tvwqglecaa kcivnnvsae tvqtvrykyg ynageathha vdsavnvgvt
      601 ayninnigik amvkktatqt ghtlledyqi vdnsqrenqe gaanvnvrge kdeqtkevke
      661 akkkdk
//
LOCUS       XP_047286168             666 aa            linear   PRI 05-AUG-2025
DEFINITION  spartin isoform X1 [Homo sapiens].
ACCESSION   XP_047286168
VERSION     XP_047286168.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430212.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..666
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..666
                     /product="spartin isoform X1"
                     /calculated_mol_wt=72702
     Region          16..95
                     /region_name="MIT_spastin"
                     /note="MIT: domain contained within Microtubule
                     Interacting and Trafficking molecules. This MIT domain
                     sub-family is found in the AAA protein spastin, a probable
                     ATPase involved in the assembly or function of nuclear
                     protein complexes; spastins might also be...; cd02679"
                     /db_xref="CDD:239142"
     Region          427..617
                     /region_name="Senescence"
                     /note="Senescence domain; pfam06911"
                     /db_xref="CDD:462037"
     CDS             1..666
                     /gene="SPART"
                     /gene_synonym="SPG20; TAHCCP1"
                     /coded_by="XM_047430212.1:470..2470"
                     /db_xref="GeneID:23111"
                     /db_xref="HGNC:HGNC:18514"
                     /db_xref="MIM:607111"
ORIGIN      
        1 meqepqngep aeikiireay kkaflfvnkg lntdelgqke eaknyykqgi ghllrgisis
       61 skesehtgpg wesarqmqqk mketlqnvrt rleilekgla tslqndlqev pklypefppk
      121 dmceklpepq sfssapqhae vngntstpsa gavaapasls lpsqscpaea ppaytpqaae
      181 ghytvsygtd sgefssvgee fyrnhsqppp letlgldade lilipngvqi ffvnpagevs
      241 apsypgylri vrfldnsldt vlnrppgflq vcdwlyplvp drspvlkcta gaymfpdtml
      301 qaagcfvgvv lsselpeddr elfedllrqm sdlrlqanwn raeeenefqi pgrtrpssdq
      361 lkeasgtdvk qldqgnkdvr hkgkrgkrak dtsseevnls hivpcepvpe ekpkelpews
      421 ekvahnilsg aswvswglvk gaeitgkaiq kgasklreri qpeekpvevs pavtkglyia
      481 kqatggaakv sqflvdgvct vancvgkela phvkkhgskl vpeslkkdkd gkspldgamv
      541 vaassvqgfs tvwqglecaa kcivnnvsae tvqtvrykyg ynageathha vdsavnvgvt
      601 ayninnigik amvkktatqt ghtlledyqi vdnsqrenqe gaanvnvrge kdeqtkevke
      661 akkkdk
//
LOCUS       XP_047286169             666 aa            linear   PRI 05-AUG-2025
DEFINITION  spartin isoform X1 [Homo sapiens].
ACCESSION   XP_047286169
VERSION     XP_047286169.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430213.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..666
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..666
                     /product="spartin isoform X1"
                     /calculated_mol_wt=72702
     Region          16..95
                     /region_name="MIT_spastin"
                     /note="MIT: domain contained within Microtubule
                     Interacting and Trafficking molecules. This MIT domain
                     sub-family is found in the AAA protein spastin, a probable
                     ATPase involved in the assembly or function of nuclear
                     protein complexes; spastins might also be...; cd02679"
                     /db_xref="CDD:239142"
     Region          427..617
                     /region_name="Senescence"
                     /note="Senescence domain; pfam06911"
                     /db_xref="CDD:462037"
     CDS             1..666
                     /gene="SPART"
                     /gene_synonym="SPG20; TAHCCP1"
                     /coded_by="XM_047430213.1:230..2230"
                     /db_xref="GeneID:23111"
                     /db_xref="HGNC:HGNC:18514"
                     /db_xref="MIM:607111"
ORIGIN      
        1 meqepqngep aeikiireay kkaflfvnkg lntdelgqke eaknyykqgi ghllrgisis
       61 skesehtgpg wesarqmqqk mketlqnvrt rleilekgla tslqndlqev pklypefppk
      121 dmceklpepq sfssapqhae vngntstpsa gavaapasls lpsqscpaea ppaytpqaae
      181 ghytvsygtd sgefssvgee fyrnhsqppp letlgldade lilipngvqi ffvnpagevs
      241 apsypgylri vrfldnsldt vlnrppgflq vcdwlyplvp drspvlkcta gaymfpdtml
      301 qaagcfvgvv lsselpeddr elfedllrqm sdlrlqanwn raeeenefqi pgrtrpssdq
      361 lkeasgtdvk qldqgnkdvr hkgkrgkrak dtsseevnls hivpcepvpe ekpkelpews
      421 ekvahnilsg aswvswglvk gaeitgkaiq kgasklreri qpeekpvevs pavtkglyia
      481 kqatggaakv sqflvdgvct vancvgkela phvkkhgskl vpeslkkdkd gkspldgamv
      541 vaassvqgfs tvwqglecaa kcivnnvsae tvqtvrykyg ynageathha vdsavnvgvt
      601 ayninnigik amvkktatqt ghtlledyqi vdnsqrenqe gaanvnvrge kdeqtkevke
      661 akkkdk
//
LOCUS       XP_005266374             666 aa            linear   PRI 05-AUG-2025
DEFINITION  spartin isoform X1 [Homo sapiens].
ACCESSION   XP_005266374
VERSION     XP_005266374.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266317.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..666
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..666
                     /product="spartin isoform X1"
                     /calculated_mol_wt=72702
     Region          16..95
                     /region_name="MIT_spastin"
                     /note="MIT: domain contained within Microtubule
                     Interacting and Trafficking molecules. This MIT domain
                     sub-family is found in the AAA protein spastin, a probable
                     ATPase involved in the assembly or function of nuclear
                     protein complexes; spastins might also be...; cd02679"
                     /db_xref="CDD:239142"
     Region          427..617
                     /region_name="Senescence"
                     /note="Senescence domain; pfam06911"
                     /db_xref="CDD:462037"
     CDS             1..666
                     /gene="SPART"
                     /gene_synonym="SPG20; TAHCCP1"
                     /coded_by="XM_005266317.4:53..2053"
                     /db_xref="GeneID:23111"
                     /db_xref="HGNC:HGNC:18514"
                     /db_xref="MIM:607111"
ORIGIN      
        1 meqepqngep aeikiireay kkaflfvnkg lntdelgqke eaknyykqgi ghllrgisis
       61 skesehtgpg wesarqmqqk mketlqnvrt rleilekgla tslqndlqev pklypefppk
      121 dmceklpepq sfssapqhae vngntstpsa gavaapasls lpsqscpaea ppaytpqaae
      181 ghytvsygtd sgefssvgee fyrnhsqppp letlgldade lilipngvqi ffvnpagevs
      241 apsypgylri vrfldnsldt vlnrppgflq vcdwlyplvp drspvlkcta gaymfpdtml
      301 qaagcfvgvv lsselpeddr elfedllrqm sdlrlqanwn raeeenefqi pgrtrpssdq
      361 lkeasgtdvk qldqgnkdvr hkgkrgkrak dtsseevnls hivpcepvpe ekpkelpews
      421 ekvahnilsg aswvswglvk gaeitgkaiq kgasklreri qpeekpvevs pavtkglyia
      481 kqatggaakv sqflvdgvct vancvgkela phvkkhgskl vpeslkkdkd gkspldgamv
      541 vaassvqgfs tvwqglecaa kcivnnvsae tvqtvrykyg ynageathha vdsavnvgvt
      601 ayninnigik amvkktatqt ghtlledyqi vdnsqrenqe gaanvnvrge kdeqtkevke
      661 akkkdk
//
LOCUS       XP_016875972             731 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat and calponin homology domain-containing protein
            1 isoform X1 [Homo sapiens].
ACCESSION   XP_016875972
VERSION     XP_016875972.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020483.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..731
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..731
                     /product="leucine-rich repeat and calponin homology
                     domain-containing protein 1 isoform X1"
                     /calculated_mol_wt=80830
     Region          56..>272
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          76..98
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          99..121
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          122..144
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          145..160
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          167..189
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          190..212
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          213..234
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          235..257
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          258..277
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          612..722
                     /region_name="CH_LRCH2"
                     /note="calponin homology (CH) domain found in leucine-rich
                     repeat and calponin homology domain-containing protein 2;
                     cd21271"
                     /db_xref="CDD:409120"
     Site            order(617,621,676,678..679,682..683,685,695..703,709,
                     711..712,714..715,718..719,722)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409120"
     CDS             1..731
                     /gene="LRCH1"
                     /gene_synonym="CHDC1; NP81"
                     /coded_by="XM_017020483.2:228..2423"
                     /db_xref="GeneID:23143"
                     /db_xref="HGNC:HGNC:20309"
                     /db_xref="MIM:610368"
ORIGIN      
        1 matpgsepqp fvpalsvatl hplhhphhhh hhhqhhggtg apggaggggg gsggfnlpln
       61 rgleraleea ansgglnlsa rklkefprta apghdlsdtv qadlsknrlv evpmelchfv
      121 sleilnlyhn cirvipeaiv nlqmltylnl srnqlsalpa clcglplkvl iasnnklgsl
      181 peeigqlkql meldvscnei talpqqigql kslrelnvrr nylkvlpqel vdlslvkfdf
      241 scnkvlvipi cfremkqlqv lllennplqs ppaqictkgk vhifkylsiq acqiktadsl
      301 ylhtmerphl hqhvedgkkd sdsgvgsdng dkrlsateps dedtvslnvp msnimeeeqi
      361 ikedschrls pvkgefhqef qpepsllgds tnsgeerdqf tdradglhse fmnykaraed
      421 ceellrieed vhwqtegiis sskdqdmdia mieqlreavd llqdpnglst ditersvlnl
      481 ypmgsaeale lqdsalngqi qletspvcev qsdltlqsng sqyspneire nspavspttn
      541 stapfglkpr sdpalilppi sfntltqaqt wdsssysvps egdsdnvflr pqrnlesidp
      601 qftirrkmeq mreekelveq lresiemrlk vslhedlgaa lmdgvvlchl vnhirprsva
      661 sihvpspavp klsmakcrrn venfleacrk lgvpeeklcl phhileekgl vkvgitiqal
      721 lditvtkalf t
//
LOCUS       XP_047286170             558 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat and calponin homology domain-containing protein
            1 isoform X2 [Homo sapiens].
ACCESSION   XP_047286170
VERSION     XP_047286170.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430214.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..558
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..558
                     /product="leucine-rich repeat and calponin homology
                     domain-containing protein 1 isoform X2"
                     /calculated_mol_wt=61251
     Region          56..>272
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          76..98
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          99..121
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          122..144
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          145..160
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          167..189
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          190..212
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          213..234
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          235..257
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          258..277
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     CDS             1..558
                     /gene="LRCH1"
                     /gene_synonym="CHDC1; NP81"
                     /coded_by="XM_047430214.1:228..1904"
                     /db_xref="GeneID:23143"
                     /db_xref="HGNC:HGNC:20309"
                     /db_xref="MIM:610368"
ORIGIN      
        1 matpgsepqp fvpalsvatl hplhhphhhh hhhqhhggtg apggaggggg gsggfnlpln
       61 rgleraleea ansgglnlsa rklkefprta apghdlsdtv qadlsknrlv evpmelchfv
      121 sleilnlyhn cirvipeaiv nlqmltylnl srnqlsalpa clcglplkvl iasnnklgsl
      181 peeigqlkql meldvscnei talpqqigql kslrelnvrr nylkvlpqel vdlslvkfdf
      241 scnkvlvipi cfremkqlqv lllennplqs ppaqictkgk vhifkylsiq acqiktadsl
      301 ylhtmerphl hqhvedgkkd sdsgvgsdng dkrlsateps dedtvslnvp msnimeeeqi
      361 ikedschrls pvkgefhqef qpepsllgds tnsgeerdqf tdradglhse fmnykaraed
      421 ceellrieed vhwqtegiis sskdqdmdia mieqlreavd llqdpnglst ditersvlnl
      481 ypmgsaeale lqdsalngqi qletspvcev qsdltlqsng sqyspneire nspavspttn
      541 stapfglkpr sgtdmgql
//
LOCUS       XP_011533317             974 aa            linear   PRI 05-AUG-2025
DEFINITION  receptor-type tyrosine-protein kinase FLT3 isoform X1 [Homo
            sapiens].
ACCESSION   XP_011533317
VERSION     XP_011533317.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535015.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..974
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..974
                     /product="receptor-type tyrosine-protein kinase FLT3
                     isoform X1"
                     /calculated_mol_wt=110836
     Region          237..326
                     /region_name="ig"
                     /note="Immunoglobulin domain; pfam00047"
                     /db_xref="CDD:395002"
     Region          249..253
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          263..267
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          295..298
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          308..313
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          321..324
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          553..928
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Site            order(597..600,603,605,623,625,656,672..675,792,796..797,
                     799,809..810)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270870"
     CDS             1..974
                     /gene="FLT3"
                     /gene_synonym="CD135; FLK-2; FLK2; STK1"
                     /coded_by="XM_011535015.3:140..3064"
                     /db_xref="GeneID:2322"
                     /db_xref="HGNC:HGNC:3765"
                     /db_xref="MIM:136351"
ORIGIN      
        1 mifgtitnqd lpvikcvlin hknndssvgk sssypmvses pedlgcalrp qssgtvyeaa
       61 avevdvsasi tlqvlvdapg nisclwvfkh sslncqphfd lqnrgvvsmv ilkmtetqag
      121 eyllfiqsea tnytilftvs irntllytlr rpyfrkmenq dalvcisesv pepivewvlc
      181 dsqgesckee spavvkkeek vlhelfgtdi rccarnelgr ectrlftidl nqtpqttlpq
      241 lflkvgeplw irckavhvnh gfgltwelen kaleegnyfe mstystnrtm irilfafvss
      301 varndtgyyt cssskhpsqs alvtivekgf inatnssedy eidqyeefcf svrfkaypqi
      361 rctwtfsrks fpceqkgldn gysiskfcnh khqpgeyifh aenddaqftk mftlnirrkp
      421 qvlaeasasq ascfsdgypl pswtwkkcsd kspncteeit egvwnrkanr kvfgqwvsss
      481 tlnmseaikg flvkccayns lgtscetill nspgpfpfiq dnisfyatig vcllfivvlt
      541 llichkykkq fryesqlqmv qvtgssdney fyvdfreyey dlkwefpren lefgkvlgsg
      601 afgkvmnata ygisktgvsi qvavkmlkek adsserealm selkmmtqlg shenivnllg
      661 actlsgpiyl ifeyccygdl lnylrskrek fhrtwteifk ehnfsfyptf qshpnssmpg
      721 srevqihpds dqisglhgns fhsedeieye nqkrleeeed lnvltfedll cfayqvakgm
      781 eflefkscvh rdlaarnvlv thgkvvkicd fglardimsd snyvvrgnar lpvkwmapes
      841 lfegiytiks dvwsygillw eifslgvnpy pgipvdanfy kliqngfkmd qpfyateeiy
      901 iimqscwafd srkrpsfpnl tsflgcqlad aeeamyqnvd grvsecphty qnrrpfsrem
      961 dlgllspqaq veds
//
LOCUS       XP_047286172             818 aa            linear   PRI 05-AUG-2025
DEFINITION  receptor-type tyrosine-protein kinase FLT3 isoform X2 [Homo
            sapiens].
ACCESSION   XP_047286172
VERSION     XP_047286172.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430216.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..818
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..818
                     /product="receptor-type tyrosine-protein kinase FLT3
                     isoform X2"
                     /calculated_mol_wt=93545
     Region          81..170
                     /region_name="ig"
                     /note="Immunoglobulin domain; pfam00047"
                     /db_xref="CDD:395002"
     Region          93..97
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          107..111
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          139..142
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          152..157
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          165..168
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          397..772
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Site            order(441..444,447,449,467,469,500,516..519,636,640..641,
                     643,653..654)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270870"
     CDS             1..818
                     /gene="FLT3"
                     /gene_synonym="CD135; FLK-2; FLK2; STK1"
                     /coded_by="XM_047430216.1:213..2669"
                     /db_xref="GeneID:2322"
                     /db_xref="HGNC:HGNC:3765"
                     /db_xref="MIM:136351"
ORIGIN      
        1 menqdalvci sesvpepive wvlcdsqges ckeespavvk keekvlhelf gtdirccarn
       61 elgrectrlf tidlnqtpqt tlpqlflkvg eplwirckav hvnhgfgltw elenkaleeg
      121 nyfemstyst nrtmirilfa fvssvarndt gyytcssskh psqsalvtiv ekgfinatns
      181 sedyeidqye efcfsvrfka ypqirctwtf srksfpceqk gldngysisk fcnhkhqpge
      241 yifhaendda qftkmftlni rrkpqvlaea sasqascfsd gyplpswtwk kcsdkspnct
      301 eeitegvwnr kanrkvfgqw vssstlnmse aikgflvkcc aynslgtsce tillnspgpf
      361 pfiqdnisfy atigvcllfi vvltllichk ykkqfryesq lqmvqvtgss dneyfyvdfr
      421 eyeydlkwef prenlefgkv lgsgafgkvm nataygiskt gvsiqvavkm lkekadsser
      481 ealmselkmm tqlgsheniv nllgactlsg piylifeycc ygdllnylrs krekfhrtwt
      541 eifkehnfsf yptfqshpns smpgsrevqi hpdsdqisgl hgnsfhsede ieyenqkrle
      601 eeedlnvltf edllcfayqv akgmeflefk scvhrdlaar nvlvthgkvv kicdfglard
      661 imsdsnyvvr gnarlpvkwm apeslfegiy tiksdvwsyg illweifslg vnpypgipvd
      721 anfykliqng fkmdqpfyat eeiyiimqsc wafdsrkrps fpnltsflgc qladaeeamy
      781 qnvdgrvsec phtyqnrrpf sremdlglls pqaqveds
//
LOCUS       XP_011533320             818 aa            linear   PRI 05-AUG-2025
DEFINITION  receptor-type tyrosine-protein kinase FLT3 isoform X2 [Homo
            sapiens].
ACCESSION   XP_011533320
VERSION     XP_011533320.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535018.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..818
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..818
                     /product="receptor-type tyrosine-protein kinase FLT3
                     isoform X2"
                     /calculated_mol_wt=93545
     Region          81..170
                     /region_name="ig"
                     /note="Immunoglobulin domain; pfam00047"
                     /db_xref="CDD:395002"
     Region          93..97
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          107..111
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          139..142
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          152..157
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          165..168
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          397..772
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Site            order(441..444,447,449,467,469,500,516..519,636,640..641,
                     643,653..654)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270870"
     CDS             1..818
                     /gene="FLT3"
                     /gene_synonym="CD135; FLK-2; FLK2; STK1"
                     /coded_by="XM_011535018.3:115..2571"
                     /db_xref="GeneID:2322"
                     /db_xref="HGNC:HGNC:3765"
                     /db_xref="MIM:136351"
ORIGIN      
        1 menqdalvci sesvpepive wvlcdsqges ckeespavvk keekvlhelf gtdirccarn
       61 elgrectrlf tidlnqtpqt tlpqlflkvg eplwirckav hvnhgfgltw elenkaleeg
      121 nyfemstyst nrtmirilfa fvssvarndt gyytcssskh psqsalvtiv ekgfinatns
      181 sedyeidqye efcfsvrfka ypqirctwtf srksfpceqk gldngysisk fcnhkhqpge
      241 yifhaendda qftkmftlni rrkpqvlaea sasqascfsd gyplpswtwk kcsdkspnct
      301 eeitegvwnr kanrkvfgqw vssstlnmse aikgflvkcc aynslgtsce tillnspgpf
      361 pfiqdnisfy atigvcllfi vvltllichk ykkqfryesq lqmvqvtgss dneyfyvdfr
      421 eyeydlkwef prenlefgkv lgsgafgkvm nataygiskt gvsiqvavkm lkekadsser
      481 ealmselkmm tqlgsheniv nllgactlsg piylifeycc ygdllnylrs krekfhrtwt
      541 eifkehnfsf yptfqshpns smpgsrevqi hpdsdqisgl hgnsfhsede ieyenqkrle
      601 eeedlnvltf edllcfayqv akgmeflefk scvhrdlaar nvlvthgkvv kicdfglard
      661 imsdsnyvvr gnarlpvkwm apeslfegiy tiksdvwsyg illweifslg vnpypgipvd
      721 anfykliqng fkmdqpfyat eeiyiimqsc wafdsrkrps fpnltsflgc qladaeeamy
      781 qnvdgrvsec phtyqnrrpf sremdlglls pqaqveds
//
LOCUS       XP_016875977             700 aa            linear   PRI 05-AUG-2025
DEFINITION  receptor-type tyrosine-protein kinase FLT3 isoform X3 [Homo
            sapiens].
ACCESSION   XP_016875977
VERSION     XP_016875977.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020488.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..700
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..700
                     /product="receptor-type tyrosine-protein kinase FLT3
                     isoform X3"
                     /calculated_mol_wt=80074
     Region          279..654
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Site            order(323..326,329,331,349,351,382,398..401,518,522..523,
                     525,535..536)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:133186"
     CDS             1..700
                     /gene="FLT3"
                     /gene_synonym="CD135; FLK-2; FLK2; STK1"
                     /coded_by="XM_017020488.2:272..2374"
                     /db_xref="GeneID:2322"
                     /db_xref="HGNC:HGNC:3765"
                     /db_xref="MIM:136351"
ORIGIN      
        1 mdkvqscsce pwirahlgir kqstrgvarn dtgyytcsss khpsqsalvt ivekgfinat
       61 nssedyeidq yeefcfsvrf kaypqirctw tfsrksfpce qkgldngysi skfcnhkhqp
      121 geyifhaend daqftkmftl nirrkpqvla easasqascf sdgyplpswt wkkcsdkspn
      181 cteeitegvw nrkanrkvfg qwvssstlnm seaikgflvk ccaynslgts cetillnspg
      241 pfpfiqdnis fyatigvcll fivvltllic hkykkqfrye sqlqmvqvtg ssdneyfyvd
      301 freyeydlkw efprenlefg kvlgsgafgk vmnataygis ktgvsiqvav kmlkekadss
      361 erealmselk mmtqlgshen ivnllgactl sgpiylifey ccygdllnyl rskrekfhrt
      421 wteifkehnf sfyptfqshp nssmpgsrev qihpdsdqis glhgnsfhse deieyenqkr
      481 leeeedlnvl tfedllcfay qvakgmefle fkscvhrdla arnvlvthgk vvkicdfgla
      541 rdimsdsnyv vrgnarlpvk wmapeslfeg iytiksdvws ygillweifs lgvnpypgip
      601 vdanfykliq ngfkmdqpfy ateeiyiimq scwafdsrkr psfpnltsfl gcqladaeea
      661 myqnvdgrvs ecphtyqnrr pfsremdlgl lspqaqveds
//
LOCUS       XP_016875979            1169 aa            linear   PRI 05-AUG-2025
DEFINITION  phospholipid-transporting ATPase IH isoform X1 [Homo sapiens].
ACCESSION   XP_016875979
VERSION     XP_016875979.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020490.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1169
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1169
                     /product="phospholipid-transporting ATPase IH isoform X1"
                     /calculated_mol_wt=133200
     Region          47..983
                     /region_name="P-type_ATPase_APLT_Dnf-like"
                     /note="Aminophospholipid translocases (APLTs), similar to
                     Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2,
                     -10D, -11B, -11C; cd02073"
                     /db_xref="CDD:319770"
     Site            order(414..416,553,576..578,640,687..689,798,801,804,825,
                     828)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:319770"
     Region          <965..1061
                     /region_name="RDD"
                     /note="RDD family; cl00746"
                     /db_xref="CDD:469900"
     CDS             1..1169
                     /gene="ATP11A"
                     /gene_synonym="ATPIH; ATPIS; AUNA2; DFNA84; HLD24"
                     /coded_by="XM_017020490.2:380..3889"
                     /db_xref="GeneID:23250"
                     /db_xref="HGNC:HGNC:13552"
                     /db_xref="MIM:605868"
ORIGIN      
        1 mdcslvrtlv hrycageenw vdsrtiyvgh repppgaeay ipqrypdnri vsskytfwnf
       61 ipknlfeqfr rvanfyflii flvqliidtp tspvtsglpl ffvitvtaik qgyedwlrhk
      121 adnamnqcpv hfiqhgklvr kqsrklrvgd ivmvkedetf pcdliflssn rgdgtchvtt
      181 asldgesshk thyavqdtkg fhteediggl hatieceqpq pdlykfvgri nvysdlndpv
      241 vrplgsenll lrgatlknte kifgvaiytg metkmalnyq sksqkrsave ksmnaflivy
      301 lciliskali ntvlkymwqs epfrdepwyn qkteserqrn lflkaftdfl afmvlfnyii
      361 pvsmyvtvem qkflgsyfit wdedmfdeet gegplvntsd lneelgqvey iftdktgtlt
      421 ennmefkecc ieghvyvphv icngqvlpes sgidmidssp svngrereel ffralclcht
      481 vqvkdddsvd gprkspdggk scvyissspd evalvegvqr lgftylrlkd nymeilnren
      541 hierfellei lsfdsvrrrm svivksatge iylfckgads sifprviegk vdqirarver
      601 naveglrtlc vaykrliqee yegickllqa akvalqdrek klaeayeqie kdltllgata
      661 vedrlqekaa dtiealqkag ikvwvltgdk metaaatcya cklfrrntql lelttkriee
      721 qslhdvlfel sktvlrhsgs ltrdnlsgls admqdyglii dgaalslimk predgssgny
      781 relfleicrs csavlccrma plqkaqivkl ikfskehpit laigdgandv smileahvgi
      841 gvigkegrqa arnsdyaipk fkhlkkmllv hghfyyiris elvqyffykn vcfifpqfly
      901 qffcgfsqqt lydtayltly nisftslpil lyslmeqhvg idvlkrdptl yrdvaknall
      961 rwrvfiywtl lglfdalvff fgayfvfent tvtsngqifg nwtfgtlvft vmvftvtlkl
     1021 aldthywtwi nhfviwgsll fyvvfsllwg gviwpflnyq rmyyvfiqml ssgpawlaiv
     1081 llvtisllpd vlkkvlcrql wptatervqq lasafklnpk seavttthlc cftgkpacpq
     1141 raaapvtvpq dsinnasfqv sspkfpitp
//
LOCUS       XP_016875980            1168 aa            linear   PRI 05-AUG-2025
DEFINITION  phospholipid-transporting ATPase IH isoform X2 [Homo sapiens].
ACCESSION   XP_016875980
VERSION     XP_016875980.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020491.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1168
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1168
                     /product="phospholipid-transporting ATPase IH isoform X2"
                     /calculated_mol_wt=133072
     Region          47..983
                     /region_name="P-type_ATPase_APLT_Dnf-like"
                     /note="Aminophospholipid translocases (APLTs), similar to
                     Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2,
                     -10D, -11B, -11C; cd02073"
                     /db_xref="CDD:319770"
     Site            order(414..416,553,576..578,640,687..689,798,801,804,825,
                     828)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:319770"
     Region          <965..1061
                     /region_name="RDD"
                     /note="RDD family; cl00746"
                     /db_xref="CDD:469900"
     CDS             1..1168
                     /gene="ATP11A"
                     /gene_synonym="ATPIH; ATPIS; AUNA2; DFNA84; HLD24"
                     /coded_by="XM_017020491.2:380..3886"
                     /db_xref="GeneID:23250"
                     /db_xref="HGNC:HGNC:13552"
                     /db_xref="MIM:605868"
ORIGIN      
        1 mdcslvrtlv hrycageenw vdsrtiyvgh repppgaeay ipqrypdnri vsskytfwnf
       61 ipknlfeqfr rvanfyflii flvqliidtp tspvtsglpl ffvitvtaik qgyedwlrhk
      121 adnamnqcpv hfiqhgklvr kqsrklrvgd ivmvkedetf pcdliflssn rgdgtchvtt
      181 asldgesshk thyavqdtkg fhteediggl hatieceqpq pdlykfvgri nvysdlndpv
      241 vrplgsenll lrgatlknte kifgvaiytg metkmalnyq sksqkrsave ksmnaflivy
      301 lciliskali ntvlkymwqs epfrdepwyn qkteserqrn lflkaftdfl afmvlfnyii
      361 pvsmyvtvem qkflgsyfit wdedmfdeet gegplvntsd lneelgqvey iftdktgtlt
      421 ennmefkecc ieghvyvphv icngqvlpes sgidmidssp svngrereel ffralclcht
      481 vqvkdddsvd gprkspdggk scvyissspd evalvegvqr lgftylrlkd nymeilnren
      541 hierfellei lsfdsvrrrm svivksatge iylfckgads sifprviegk vdqirarver
      601 naveglrtlc vaykrliqee yegickllqa akvalqdrek klaeayeqie kdltllgata
      661 vedrlqekaa dtiealqkag ikvwvltgdk metaaatcya cklfrrntql lelttkriee
      721 qslhdvlfel sktvlrhsgs ltrdnlsgls admqdyglii dgaalslimk predgssgny
      781 relfleicrs csavlccrma plqkaqivkl ikfskehpit laigdgandv smileahvgi
      841 gvigkegrqa arnsdyaipk fkhlkkmllv hghfyyiris elvqyffykn vcfifpqfly
      901 qffcgfsqqt lydtayltly nisftslpil lyslmeqhvg idvlkrdptl yrdvaknall
      961 rwrvfiywtl lglfdalvff fgayfvfent tvtsngqifg nwtfgtlvft vmvftvtlkl
     1021 aldthywtwi nhfviwgsll fyvvfsllwg gviwpflnyq rmyyvfiqml ssgpawlaiv
     1081 llvtisllpd vlkkvlcrql wptatervql asafklnpks eavttthlcc ftgkpacpqr
     1141 aaapvtvpqd sinnasfqvs spkfpitp
//
LOCUS       XP_011535782            1139 aa            linear   PRI 05-AUG-2025
DEFINITION  phospholipid-transporting ATPase IH isoform X3 [Homo sapiens].
ACCESSION   XP_011535782
VERSION     XP_011535782.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537480.3
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 5% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1139
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1139
                     /product="phospholipid-transporting ATPase IH isoform X3"
                     /calculated_mol_wt=130223
     Region          47..983
                     /region_name="P-type_ATPase_APLT_Dnf-like"
                     /note="Aminophospholipid translocases (APLTs), similar to
                     Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2,
                     -10D, -11B, -11C; cd02073"
                     /db_xref="CDD:319770"
     Site            order(414..416,553,576..578,640,687..689,798,801,804,825,
                     828)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:319770"
     CDS             1..1139
                     /gene="ATP11A"
                     /gene_synonym="ATPIH; ATPIS; AUNA2; DFNA84; HLD24"
                     /coded_by="XM_011537480.3:380..3799"
                     /db_xref="GeneID:23250"
                     /db_xref="HGNC:HGNC:13552"
                     /db_xref="MIM:605868"
ORIGIN      
        1 mdcslvrtlv hrycageenw vdsrtiyvgh repppgaeay ipqrypdnri vsskytfwnf
       61 ipknlfeqfr rvanfyflii flvqliidtp tspvtsglpl ffvitvtaik qgyedwlrhk
      121 adnamnqcpv hfiqhgklvr kqsrklrvgd ivmvkedetf pcdliflssn rgdgtchvtt
      181 asldgesshk thyavqdtkg fhteediggl hatieceqpq pdlykfvgri nvysdlndpv
      241 vrplgsenll lrgatlknte kifgvaiytg metkmalnyq sksqkrsave ksmnaflivy
      301 lciliskali ntvlkymwqs epfrdepwyn qkteserqrn lflkaftdfl afmvlfnyii
      361 pvsmyvtvem qkflgsyfit wdedmfdeet gegplvntsd lneelgqvey iftdktgtlt
      421 ennmefkecc ieghvyvphv icngqvlpes sgidmidssp svngrereel ffralclcht
      481 vqvkdddsvd gprkspdggk scvyissspd evalvegvqr lgftylrlkd nymeilnren
      541 hierfellei lsfdsvrrrm svivksatge iylfckgads sifprviegk vdqirarver
      601 naveglrtlc vaykrliqee yegickllqa akvalqdrek klaeayeqie kdltllgata
      661 vedrlqekaa dtiealqkag ikvwvltgdk metaaatcya cklfrrntql lelttkriee
      721 qslhdvlfel sktvlrhsgs ltrdnlsgls admqdyglii dgaalslimk predgssgny
      781 relfleicrs csavlccrma plqkaqivkl ikfskehpit laigdgandv smileahvgi
      841 gvigkegrqa arnsdyaipk fkhlkkmllv hghfyyiris elvqyffykn vcfifpqfly
      901 qffcgfsqqt lydtayltly nisftslpil lyslmeqhvg idvlkrdptl yrdvaknall
      961 rwrvfiywtl lglfdalvff fgayfvfent tvtsngqifg nwtfgtlvft vmvftvtlkl
     1021 aldthywtwi nhfviwgsll fyvvfsllwg gviwpflnyq rmyyvfiqml ssgpawlaiv
     1081 llvtisllpd vlkkvlcrql wptatervqr gvkhkapvqa aqssdgpllk dllrrprrs
//
LOCUS       XP_005268360            1139 aa            linear   PRI 05-AUG-2025
DEFINITION  phospholipid-transporting ATPase IH isoform X3 [Homo sapiens].
ACCESSION   XP_005268360
VERSION     XP_005268360.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005268303.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1139
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1139
                     /product="phospholipid-transporting ATPase IH isoform X3"
                     /calculated_mol_wt=130223
     Region          47..983
                     /region_name="P-type_ATPase_APLT_Dnf-like"
                     /note="Aminophospholipid translocases (APLTs), similar to
                     Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2,
                     -10D, -11B, -11C; cd02073"
                     /db_xref="CDD:319770"
     Site            order(414..416,553,576..578,640,687..689,798,801,804,825,
                     828)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:319770"
     CDS             1..1139
                     /gene="ATP11A"
                     /gene_synonym="ATPIH; ATPIS; AUNA2; DFNA84; HLD24"
                     /coded_by="XM_005268303.5:380..3799"
                     /db_xref="GeneID:23250"
                     /db_xref="HGNC:HGNC:13552"
                     /db_xref="MIM:605868"
ORIGIN      
        1 mdcslvrtlv hrycageenw vdsrtiyvgh repppgaeay ipqrypdnri vsskytfwnf
       61 ipknlfeqfr rvanfyflii flvqliidtp tspvtsglpl ffvitvtaik qgyedwlrhk
      121 adnamnqcpv hfiqhgklvr kqsrklrvgd ivmvkedetf pcdliflssn rgdgtchvtt
      181 asldgesshk thyavqdtkg fhteediggl hatieceqpq pdlykfvgri nvysdlndpv
      241 vrplgsenll lrgatlknte kifgvaiytg metkmalnyq sksqkrsave ksmnaflivy
      301 lciliskali ntvlkymwqs epfrdepwyn qkteserqrn lflkaftdfl afmvlfnyii
      361 pvsmyvtvem qkflgsyfit wdedmfdeet gegplvntsd lneelgqvey iftdktgtlt
      421 ennmefkecc ieghvyvphv icngqvlpes sgidmidssp svngrereel ffralclcht
      481 vqvkdddsvd gprkspdggk scvyissspd evalvegvqr lgftylrlkd nymeilnren
      541 hierfellei lsfdsvrrrm svivksatge iylfckgads sifprviegk vdqirarver
      601 naveglrtlc vaykrliqee yegickllqa akvalqdrek klaeayeqie kdltllgata
      661 vedrlqekaa dtiealqkag ikvwvltgdk metaaatcya cklfrrntql lelttkriee
      721 qslhdvlfel sktvlrhsgs ltrdnlsgls admqdyglii dgaalslimk predgssgny
      781 relfleicrs csavlccrma plqkaqivkl ikfskehpit laigdgandv smileahvgi
      841 gvigkegrqa arnsdyaipk fkhlkkmllv hghfyyiris elvqyffykn vcfifpqfly
      901 qffcgfsqqt lydtayltly nisftslpil lyslmeqhvg idvlkrdptl yrdvaknall
      961 rwrvfiywtl lglfdalvff fgayfvfent tvtsngqifg nwtfgtlvft vmvftvtlkl
     1021 aldthywtwi nhfviwgsll fyvvfsllwg gviwpflnyq rmyyvfiqml ssgpawlaiv
     1081 llvtisllpd vlkkvlcrql wptatervqr gvkhkapvqa aqssdgpllk dllrrprrs
//
LOCUS       XP_016875981            1134 aa            linear   PRI 05-AUG-2025
DEFINITION  phospholipid-transporting ATPase IH isoform X4 [Homo sapiens].
ACCESSION   XP_016875981
VERSION     XP_016875981.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020492.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1134
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1134
                     /product="phospholipid-transporting ATPase IH isoform X4"
                     /calculated_mol_wt=129625
     Region          47..983
                     /region_name="P-type_ATPase_APLT_Dnf-like"
                     /note="Aminophospholipid translocases (APLTs), similar to
                     Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2,
                     -10D, -11B, -11C; cd02073"
                     /db_xref="CDD:319770"
     Site            order(414..416,553,576..578,640,687..689,798,801,804,825,
                     828)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:319770"
     CDS             1..1134
                     /gene="ATP11A"
                     /gene_synonym="ATPIH; ATPIS; AUNA2; DFNA84; HLD24"
                     /coded_by="XM_017020492.2:380..3784"
                     /db_xref="GeneID:23250"
                     /db_xref="HGNC:HGNC:13552"
                     /db_xref="MIM:605868"
ORIGIN      
        1 mdcslvrtlv hrycageenw vdsrtiyvgh repppgaeay ipqrypdnri vsskytfwnf
       61 ipknlfeqfr rvanfyflii flvqliidtp tspvtsglpl ffvitvtaik qgyedwlrhk
      121 adnamnqcpv hfiqhgklvr kqsrklrvgd ivmvkedetf pcdliflssn rgdgtchvtt
      181 asldgesshk thyavqdtkg fhteediggl hatieceqpq pdlykfvgri nvysdlndpv
      241 vrplgsenll lrgatlknte kifgvaiytg metkmalnyq sksqkrsave ksmnaflivy
      301 lciliskali ntvlkymwqs epfrdepwyn qkteserqrn lflkaftdfl afmvlfnyii
      361 pvsmyvtvem qkflgsyfit wdedmfdeet gegplvntsd lneelgqvey iftdktgtlt
      421 ennmefkecc ieghvyvphv icngqvlpes sgidmidssp svngrereel ffralclcht
      481 vqvkdddsvd gprkspdggk scvyissspd evalvegvqr lgftylrlkd nymeilnren
      541 hierfellei lsfdsvrrrm svivksatge iylfckgads sifprviegk vdqirarver
      601 naveglrtlc vaykrliqee yegickllqa akvalqdrek klaeayeqie kdltllgata
      661 vedrlqekaa dtiealqkag ikvwvltgdk metaaatcya cklfrrntql lelttkriee
      721 qslhdvlfel sktvlrhsgs ltrdnlsgls admqdyglii dgaalslimk predgssgny
      781 relfleicrs csavlccrma plqkaqivkl ikfskehpit laigdgandv smileahvgi
      841 gvigkegrqa arnsdyaipk fkhlkkmllv hghfyyiris elvqyffykn vcfifpqfly
      901 qffcgfsqqt lydtayltly nisftslpil lyslmeqhvg idvlkrdptl yrdvaknall
      961 rwrvfiywtl lglfdalvff fgayfvfent tvtsngqifg nwtfgtlvft vmvftvtlkl
     1021 aldthywtwi nhfviwgsll fyvvfsllwg gviwpflnyq rmyyvfiqml ssgpawlaiv
     1081 llvtisllpd vlkkvlcrql wptatervqt ksqclsveqs tifmlsqtss slsf
//
LOCUS       XP_005268362            1134 aa            linear   PRI 05-AUG-2025
DEFINITION  phospholipid-transporting ATPase IH isoform X4 [Homo sapiens].
ACCESSION   XP_005268362
VERSION     XP_005268362.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005268305.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1134
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1134
                     /product="phospholipid-transporting ATPase IH isoform X4"
                     /calculated_mol_wt=129625
     Region          47..983
                     /region_name="P-type_ATPase_APLT_Dnf-like"
                     /note="Aminophospholipid translocases (APLTs), similar to
                     Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2,
                     -10D, -11B, -11C; cd02073"
                     /db_xref="CDD:319770"
     Site            order(414..416,553,576..578,640,687..689,798,801,804,825,
                     828)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:319770"
     CDS             1..1134
                     /gene="ATP11A"
                     /gene_synonym="ATPIH; ATPIS; AUNA2; DFNA84; HLD24"
                     /coded_by="XM_005268305.5:380..3784"
                     /db_xref="GeneID:23250"
                     /db_xref="HGNC:HGNC:13552"
                     /db_xref="MIM:605868"
ORIGIN      
        1 mdcslvrtlv hrycageenw vdsrtiyvgh repppgaeay ipqrypdnri vsskytfwnf
       61 ipknlfeqfr rvanfyflii flvqliidtp tspvtsglpl ffvitvtaik qgyedwlrhk
      121 adnamnqcpv hfiqhgklvr kqsrklrvgd ivmvkedetf pcdliflssn rgdgtchvtt
      181 asldgesshk thyavqdtkg fhteediggl hatieceqpq pdlykfvgri nvysdlndpv
      241 vrplgsenll lrgatlknte kifgvaiytg metkmalnyq sksqkrsave ksmnaflivy
      301 lciliskali ntvlkymwqs epfrdepwyn qkteserqrn lflkaftdfl afmvlfnyii
      361 pvsmyvtvem qkflgsyfit wdedmfdeet gegplvntsd lneelgqvey iftdktgtlt
      421 ennmefkecc ieghvyvphv icngqvlpes sgidmidssp svngrereel ffralclcht
      481 vqvkdddsvd gprkspdggk scvyissspd evalvegvqr lgftylrlkd nymeilnren
      541 hierfellei lsfdsvrrrm svivksatge iylfckgads sifprviegk vdqirarver
      601 naveglrtlc vaykrliqee yegickllqa akvalqdrek klaeayeqie kdltllgata
      661 vedrlqekaa dtiealqkag ikvwvltgdk metaaatcya cklfrrntql lelttkriee
      721 qslhdvlfel sktvlrhsgs ltrdnlsgls admqdyglii dgaalslimk predgssgny
      781 relfleicrs csavlccrma plqkaqivkl ikfskehpit laigdgandv smileahvgi
      841 gvigkegrqa arnsdyaipk fkhlkkmllv hghfyyiris elvqyffykn vcfifpqfly
      901 qffcgfsqqt lydtayltly nisftslpil lyslmeqhvg idvlkrdptl yrdvaknall
      961 rwrvfiywtl lglfdalvff fgayfvfent tvtsngqifg nwtfgtlvft vmvftvtlkl
     1021 aldthywtwi nhfviwgsll fyvvfsllwg gviwpflnyq rmyyvfiqml ssgpawlaiv
     1081 llvtisllpd vlkkvlcrql wptatervqt ksqclsveqs tifmlsqtss slsf
//
LOCUS       XP_047286174            1068 aa            linear   PRI 05-AUG-2025
DEFINITION  phospholipid-transporting ATPase IH isoform X6 [Homo sapiens].
ACCESSION   XP_047286174
VERSION     XP_047286174.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430218.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1068
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1068
                     /product="phospholipid-transporting ATPase IH isoform X6"
                     /calculated_mol_wt=121360
     Region          2..859
                     /region_name="P-type_ATPase_APLT_Dnf-like"
                     /note="Aminophospholipid translocases (APLTs), similar to
                     Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2,
                     -10D, -11B, -11C; cd02073"
                     /db_xref="CDD:319770"
     Site            order(290..292,429,452..454,516,563..565,674,677,680,701,
                     704)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:319770"
     Region          <841..937
                     /region_name="RDD"
                     /note="RDD family; cl00746"
                     /db_xref="CDD:469900"
     CDS             1..1068
                     /gene="ATP11A"
                     /gene_synonym="ATPIH; ATPIS; AUNA2; DFNA84; HLD24"
                     /coded_by="XM_047430218.1:7206..10412"
                     /db_xref="GeneID:23250"
                     /db_xref="HGNC:HGNC:13552"
                     /db_xref="MIM:605868"
ORIGIN      
        1 mnqcpvhfiq hgklvrkqsr klrvgdivmv kedetfpcdl iflssnrgdg tchvttasld
       61 gesshkthya vqdtkgfhte edigglhati eceqpqpdly kfvgrinvys dlndpvvrpl
      121 gsenlllrga tlkntekifg vaiytgmetk malnyqsksq krsaveksmn aflivylcil
      181 iskalintvl kymwqsepfr depwynqkte serqrnlflk aftdflafmv lfnyiipvsm
      241 yvtvemqkfl gsyfitwded mfdeetgegp lvntsdlnee lgqveyiftd ktgtltennm
      301 efkecciegh vyvphvicng qvlpessgid midsspsvng rereelffra lclchtvqvk
      361 dddsvdgprk spdggkscvy issspdeval vegvqrlgft ylrlkdnyme ilnrenhier
      421 felleilsfd svrrrmsviv ksatgeiylf ckgadssifp rviegkvdqi rarvernave
      481 glrtlcvayk rliqeeyegi ckllqaakva lqdrekklae ayeqiekdlt llgatavedr
      541 lqekaadtie alqkagikvw vltgdkmeta aatcyacklf rrntqllelt tkrieeqslh
      601 dvlfelsktv lrhsgsltrd nlsglsadmq dygliidgaa lslimkpred gssgnyrelf
      661 leicrscsav lccrmaplqk aqivklikfs kehpitlaig dgandvsmil eahvgigvig
      721 kegrqaarns dyaipkfkhl kkmllvhghf yyiriselvq yffyknvcfi fpqflyqffc
      781 gfsqqtlydt ayltlynisf tslpillysl meqhvgidvl krdptlyrdv aknallrwrv
      841 fiywtllglf dalvfffgay fvfenttvts ngqifgnwtf gtlvftvmvf tvtlklaldt
      901 hywtwinhfv iwgsllfyvv fsllwggviw pflnyqrmyy vfiqmlssgp awlaivllvt
      961 isllpdvlkk vlcrqlwpta tervqqngca qprdrdseft plaslqspgy qstcpsaawy
     1021 sshsqqvtla awkekvstep ppilggshhh cssipshscp rsrvgmlv
//
LOCUS       XP_047286175             747 aa            linear   PRI 05-AUG-2025
DEFINITION  phospholipid-transporting ATPase IH isoform X5 [Homo sapiens].
ACCESSION   XP_047286175
VERSION     XP_047286175.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430219.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..747
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..747
                     /product="phospholipid-transporting ATPase IH isoform X5"
                     /calculated_mol_wt=84722
     Region          47..>602
                     /region_name="Haloacid Dehalogenase-like Hydrolases"
                     /note="The haloacid dehalogenase (HAD) superfamily
                     includes carbon and phosphorus hydrolases such as
                     2-haloalkonoate dehalogenase, epoxide hydrolase,
                     phosphoserine phosphatase, phosphomannomutase,
                     phosphoglycolate phosphatase, P-type ATPase, among others.
                     These...; cl21460"
                     /db_xref="CDD:473868"
     CDS             1..747
                     /gene="ATP11A"
                     /gene_synonym="ATPIH; ATPIS; AUNA2; DFNA84; HLD24"
                     /coded_by="XM_047430219.1:380..2623"
                     /db_xref="GeneID:23250"
                     /db_xref="HGNC:HGNC:13552"
                     /db_xref="MIM:605868"
ORIGIN      
        1 mdcslvrtlv hrycageenw vdsrtiyvgh repppgaeay ipqrypdnri vsskytfwnf
       61 ipknlfeqfr rvanfyflii flvqliidtp tspvtsglpl ffvitvtaik qgyedwlrhk
      121 adnamnqcpv hfiqhgklvr kqsrklrvgd ivmvkedetf pcdliflssn rgdgtchvtt
      181 asldgesshk thyavqdtkg fhteediggl hatieceqpq pdlykfvgri nvysdlndpv
      241 vrplgsenll lrgatlknte kifgvaiytg metkmalnyq sksqkrsave ksmnaflivy
      301 lciliskali ntvlkymwqs epfrdepwyn qkteserqrn lflkaftdfl afmvlfnyii
      361 pvsmyvtvem qkflgsyfit wdedmfdeet gegplvntsd lneelgqvey iftdktgtlt
      421 ennmefkecc ieghvyvphv icngqvlpes sgidmidssp svngrereel ffralclcht
      481 vqvkdddsvd gprkspdggk scvyissspd evalvegvqr lgftylrlkd nymeilnren
      541 hierfellei lsfdsvrrrm svivksatge iylfckgads sifprviegk vdqirarver
      601 navaagescr hhrgpaegrd qslgshgrqd gdgrghvlrl qalpqehaaa gadhqedrga
      661 eparrpvrae qdgpapqrep dqrqpvrtfs ryaglrfnyr rsctvsdnea srrrefrqlq
      721 galpgnlpel qrgallphga laegsdc
//
LOCUS       XP_011535785            1211 aa            linear   PRI 05-AUG-2025
DEFINITION  guanine nucleotide exchange factor DBS isoform X2 [Homo sapiens].
ACCESSION   XP_011535785
VERSION     XP_011535785.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537483.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1211
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1211
                     /product="guanine nucleotide exchange factor DBS isoform
                     X2"
                     /calculated_mol_wt=135626
     Region          76..221
                     /region_name="SEC14"
                     /note="Domain in homologues of a S. cerevisiae
                     phosphatidylinositol transfer protein (Sec14p);
                     smart00516"
                     /db_xref="CDD:214706"
     Region          352..563
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            457..462
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          632..809
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
                     (DH) domain. It appears that PH domains invariably occur
                     C-terminal to RhoGEF/DH domains; cd00160"
                     /db_xref="CDD:238091"
     Site            order(638,642,739,761..762,765..766,768..769,772..773,
                     776..777,780,805,809)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          816..947
                     /region_name="PH_Dbs"
                     /note="DBL's big sister protein pleckstrin homology (PH)
                     domain; cd01227"
                     /db_xref="CDD:269934"
     Site            order(886,888)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:269934"
     Region          1115..1168
                     /region_name="SH3_DBS"
                     /note="Src homology 3 domain of DBL's Big Sister (DBS), a
                     guanine nucleotide exchange factor; cd11857"
                     /db_xref="CDD:212791"
     Site            order(1120,1122,1125,1129,1147..1148,1163,1165..1166)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212791"
     CDS             1..1211
                     /gene="MCF2L"
                     /gene_synonym="ARHGEF14; DBS; OST"
                     /coded_by="XM_011537483.3:171..3806"
                     /db_xref="GeneID:23263"
                     /db_xref="HGNC:HGNC:14576"
                     /db_xref="MIM:609499"
ORIGIN      
        1 mfdcwrfilc krpgsnsyss pqrpneakke etdhqidvsd virlvqdtpe atamatdeim
       61 hqdivplcaa diqdqlkkrf aylsggrgqd gspvitfpdy pafseipdke fqnvmtylts
      121 ipslqdagig filvidrrrd kwtsvkasvl riaasfpanl qlvlvlrptg ffqrtlsdia
      181 fkfnrddfkm kvpvimlssv pdlhgyidks qltedlggtl dychsrwlcq rtaiesfalm
      241 vkqtaqmlqs fgtelaetel pndvqstssv lcahtekkdk akedlrlalk eghsvleslr
      301 elqaegseps vnqdqldnqa tvqrllaqln eteaafdefw akhqqkleqc lqlrhfeqgf
      361 revkaildaa sqkiatftdi gnslahvehl lrdlasfeek sgvaverara lsldgeqlig
      421 nkhyavdsir pkcqelrhlc dqfsaeiarr rgllskslel hrrletsmkw cdegiyllas
      481 qpvdkcqsqd gaeaalqeie kfletgaenk iqelnaiyke yesilnqdlm ehvrkvfqkq
      541 asmeevfhrr qaslkklaar qtrpvqpvap rpealakspc pspgirrgse nssseggalr
      601 rgpyrrakse msesrqgrgs ageeeeslai lrrhvmsell dterayveel lcvlegyaae
      661 mdnplmahll stglhnkkdv lfgnmeeiyh fhnriflrel enytdcpelv grcflermed
      721 fqiyekycqn kprseslwrq csdcpffqec qrkldhklsl dsyllkpvqr itkyqlllke
      781 mlkysrnceg aedlqealss ilgilkavnd smhliaitgy dgnlgdlgkl lmqgsfsvwt
      841 dhkrghtkvk elarfkpmqr hlflhekavl fckkreenge gyekapsysy kqslnmaavg
      901 itenvkgdak kfeiwynare evyivqaptp eikaawvnei rkvltsqlqa creasqhral
      961 eqsqslplpa ptstspsrgn srnikkleer ktdplslegy vssapltkpp ekgkddtvts
     1021 sasessalsr krftlqgfan lkgqkaspts pdkkakrhev ksdptpfgvr gwsktshsle
     1081 apeddggwss aeeqinssda eedgglgpkk lvpgkytvva dhekggpdal rvrsgdvvel
     1141 vqegdeglwy vrdpttgkeg wvpasslsvr lgpsgsaqcl sssesspgsa vlsnssscse
     1201 ggqapfsdlq g
//
LOCUS       XP_016875983            1187 aa            linear   PRI 05-AUG-2025
DEFINITION  guanine nucleotide exchange factor DBS isoform X4 [Homo sapiens].
ACCESSION   XP_016875983
VERSION     XP_016875983.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020494.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1187
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1187
                     /product="guanine nucleotide exchange factor DBS isoform
                     X4"
                     /calculated_mol_wt=132885
     Region          52..197
                     /region_name="SEC14"
                     /note="Domain in homologues of a S. cerevisiae
                     phosphatidylinositol transfer protein (Sec14p);
                     smart00516"
                     /db_xref="CDD:214706"
     Region          328..515
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            433..438
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          608..785
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
                     (DH) domain. It appears that PH domains invariably occur
                     C-terminal to RhoGEF/DH domains; cd00160"
                     /db_xref="CDD:238091"
     Site            order(614,618,715,737..738,741..742,744..745,748..749,
                     752..753,756,781,785)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          792..923
                     /region_name="PH_Dbs"
                     /note="DBL's big sister protein pleckstrin homology (PH)
                     domain; cd01227"
                     /db_xref="CDD:269934"
     Site            order(862,864)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:269934"
     Region          1091..1144
                     /region_name="SH3_DBS"
                     /note="Src homology 3 domain of DBL's Big Sister (DBS), a
                     guanine nucleotide exchange factor; cd11857"
                     /db_xref="CDD:212791"
     Site            order(1096,1098,1101,1105,1123..1124,1139,1141..1142)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212791"
     CDS             1..1187
                     /gene="MCF2L"
                     /gene_synonym="ARHGEF14; DBS; OST"
                     /coded_by="XM_017020494.2:897..4460"
                     /db_xref="GeneID:23263"
                     /db_xref="HGNC:HGNC:14576"
                     /db_xref="MIM:609499"
ORIGIN      
        1 mgdgkavris vaemksyyly sewcswllsv aedeimhqdi vplcaadiqd qlkkrfayls
       61 ggrgqdgspv itfpdypafs eipdkefqnv mtyltsipsl qdagigfilv idrrrdkwts
      121 vkasvlriaa sfpanlqlvl vlrptgffqr tlsdiafkfn rddfkmkvpv imlssvpdlh
      181 gyidksqlte dlggtldych srwlcqrtai esfalmvkqt aqmlqsfgte laetelpndv
      241 qstssvlcah tekkdkaked lrlalkeghs vleslrelqa egsepsvnqd qldnqatvqr
      301 llaqlnetea afdefwakhq qkleqclqlr hfeqgfrevk aildaasqki atftdignsl
      361 ahvehllrdl asfeeksgva veraralsld geqlignkhy avdsirpkcq elrhlcdqfs
      421 aeiarrrgll skslelhrrl etsmkwcdeg iyllasqpvd kcqsqdgaea alqeiekfle
      481 tgaenkiqel naiykeyesi lnqdlmehvr kvfqkqasme evfhrrqasl kklaarqtrp
      541 vqpvaprpea lakspcpspg irrgsensss eggalrrgpy rraksemses rqgrgsagee
      601 eeslailrrh vmselldter ayveellcvl egyaaemdnp lmahllstgl hnkkdvlfgn
      661 meeiyhfhnr iflrelenyt dcpelvgrcf lermedfqiy ekycqnkprs eslwrqcsdc
      721 pffqecqrkl dhklsldsyl lkpvqritky qlllkemlky srncegaedl qealssilgi
      781 lkavndsmhl iaitgydgnl gdlgkllmqg sfsvwtdhkr ghtkvkelar fkpmqrhlfl
      841 hekavlfckk reengegyek apsysykqsl nmaavgiten vkgdakkfei wynareevyi
      901 vqaptpeika awvneirkvl tsqlqacrea sqhraleqsq slplpaptst spsrgnsrni
      961 kkleerktdp lslegyvssa pltkppekgk ddtvtssase ssalsrkrft lqgfanlkgq
     1021 kasptspdkk akrhevksdp tpfgvrgwsk tshsleaped dggwssaeeq inssdaeedg
     1081 glgpkklvpg kytvvadhek ggpdalrvrs gdvvelvqeg deglwyvrdp ttgkegwvpa
     1141 sslsvrlgps gsaqclssse sspgsavlsn ssscseggqa pfsdlqg
//
LOCUS       XP_011535786            1185 aa            linear   PRI 05-AUG-2025
DEFINITION  guanine nucleotide exchange factor DBS isoform X5 [Homo sapiens].
ACCESSION   XP_011535786
VERSION     XP_011535786.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537484.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1185
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1185
                     /product="guanine nucleotide exchange factor DBS isoform
                     X5"
                     /calculated_mol_wt=132649
     Region          50..195
                     /region_name="SEC14"
                     /note="Domain in homologues of a S. cerevisiae
                     phosphatidylinositol transfer protein (Sec14p);
                     smart00516"
                     /db_xref="CDD:214706"
     Region          326..513
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            431..436
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          606..783
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
                     (DH) domain. It appears that PH domains invariably occur
                     C-terminal to RhoGEF/DH domains; cd00160"
                     /db_xref="CDD:238091"
     Site            order(612,616,713,735..736,739..740,742..743,746..747,
                     750..751,754,779,783)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          790..921
                     /region_name="PH_Dbs"
                     /note="DBL's big sister protein pleckstrin homology (PH)
                     domain; cd01227"
                     /db_xref="CDD:269934"
     Site            order(860,862)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:269934"
     Region          1089..1142
                     /region_name="SH3_DBS"
                     /note="Src homology 3 domain of DBL's Big Sister (DBS), a
                     guanine nucleotide exchange factor; cd11857"
                     /db_xref="CDD:212791"
     Site            order(1094,1096,1099,1103,1121..1122,1137,1139..1140)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212791"
     CDS             1..1185
                     /gene="MCF2L"
                     /gene_synonym="ARHGEF14; DBS; OST"
                     /coded_by="XM_011537484.2:303..3860"
                     /db_xref="GeneID:23263"
                     /db_xref="HGNC:HGNC:14576"
                     /db_xref="MIM:609499"
ORIGIN      
        1 maekgasrgt lrrlwslprr rrgtagrsrp deimhqdivp lcaadiqdql kkrfaylsgg
       61 rgqdgspvit fpdypafsei pdkefqnvmt yltsipslqd agigfilvid rrrdkwtsvk
      121 asvlriaasf panlqlvlvl rptgffqrtl sdiafkfnrd dfkmkvpvim lssvpdlhgy
      181 idksqltedl ggtldychsr wlcqrtaies falmvkqtaq mlqsfgtela etelpndvqs
      241 tssvlcahte kkdkakedlr lalkeghsvl eslrelqaeg sepsvnqdql dnqatvqrll
      301 aqlneteaaf defwakhqqk leqclqlrhf eqgfrevkai ldaasqkiat ftdignslah
      361 vehllrdlas feeksgvave raralsldge qlignkhyav dsirpkcqel rhlcdqfsae
      421 iarrrgllsk slelhrrlet smkwcdegiy llasqpvdkc qsqdgaeaal qeiekfletg
      481 aenkiqelna iykeyesiln qdlmehvrkv fqkqasmeev fhrrqaslkk laarqtrpvq
      541 pvaprpeala kspcpspgir rgsenssseg galrrgpyrr aksemsesrq grgsageeee
      601 slailrrhvm selldteray veellcvleg yaaemdnplm ahllstglhn kkdvlfgnme
      661 eiyhfhnrif lrelenytdc pelvgrcfle rmedfqiyek ycqnkprses lwrqcsdcpf
      721 fqecqrkldh klsldsyllk pvqritkyql llkemlkysr ncegaedlqe alssilgilk
      781 avndsmhlia itgydgnlgd lgkllmqgsf svwtdhkrgh tkvkelarfk pmqrhlflhe
      841 kavlfckkre engegyekap sysykqslnm aavgitenvk gdakkfeiwy nareevyivq
      901 aptpeikaaw vneirkvlts qlqacreasq hraleqsqsl plpaptstsp srgnsrnikk
      961 leerktdpls legyvssapl tkppekgkdd tvtssasess alsrkrftlq gfanlkgqka
     1021 sptspdkkak rhevksdptp fgvrgwskts hsleapeddg gwssaeeqin ssdaeedggl
     1081 gpkklvpgky tvvadhekgg pdalrvrsgd vvelvqegde glwyvrdptt gkegwvpass
     1141 lsvrlgpsgs aqclsssess pgsavlsnss scseggqapf sdlqg
//
LOCUS       XP_047286178            1155 aa            linear   PRI 05-AUG-2025
DEFINITION  guanine nucleotide exchange factor DBS isoform X11 [Homo sapiens].
ACCESSION   XP_047286178
VERSION     XP_047286178.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430222.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1155
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1155
                     /product="guanine nucleotide exchange factor DBS isoform
                     X11"
                     /calculated_mol_wt=129595
     Region          76..221
                     /region_name="SEC14"
                     /note="Domain in homologues of a S. cerevisiae
                     phosphatidylinositol transfer protein (Sec14p);
                     smart00516"
                     /db_xref="CDD:214706"
     Region          352..539
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            457..462
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          632..809
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
                     (DH) domain. It appears that PH domains invariably occur
                     C-terminal to RhoGEF/DH domains; cd00160"
                     /db_xref="CDD:238091"
     Site            order(638,642,739,761..762,765..766,768..769,772..773,
                     776..777,780,805,809)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          816..947
                     /region_name="PH_Dbs"
                     /note="DBL's big sister protein pleckstrin homology (PH)
                     domain; cd01227"
                     /db_xref="CDD:269934"
     Site            order(886,888)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:269934"
     Region          1059..1112
                     /region_name="SH3_DBS"
                     /note="Src homology 3 domain of DBL's Big Sister (DBS), a
                     guanine nucleotide exchange factor; cd11857"
                     /db_xref="CDD:212791"
     Site            order(1064,1066,1069,1073,1091..1092,1107,1109..1110)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212791"
     CDS             1..1155
                     /gene="MCF2L"
                     /gene_synonym="ARHGEF14; DBS; OST"
                     /coded_by="XM_047430222.1:167..3634"
                     /db_xref="GeneID:23263"
                     /db_xref="HGNC:HGNC:14576"
                     /db_xref="MIM:609499"
ORIGIN      
        1 mfdcwrfilc krpgsnsyss pqrpneakke etdhqidvsd virlvqdtpe atamatdeim
       61 hqdivplcaa diqdqlkkrf aylsggrgqd gspvitfpdy pafseipdke fqnvmtylts
      121 ipslqdagig filvidrrrd kwtsvkasvl riaasfpanl qlvlvlrptg ffqrtlsdia
      181 fkfnrddfkm kvpvimlssv pdlhgyidks qltedlggtl dychsrwlcq rtaiesfalm
      241 vkqtaqmlqs fgtelaetel pndvqstssv lcahtekkdk akedlrlalk eghsvleslr
      301 elqaegseps vnqdqldnqa tvqrllaqln eteaafdefw akhqqkleqc lqlrhfeqgf
      361 revkaildaa sqkiatftdi gnslahvehl lrdlasfeek sgvaverara lsldgeqlig
      421 nkhyavdsir pkcqelrhlc dqfsaeiarr rgllskslel hrrletsmkw cdegiyllas
      481 qpvdkcqsqd gaeaalqeie kfletgaenk iqelnaiyke yesilnqdlm ehvrkvfqkq
      541 asmeevfhrr qaslkklaar qtrpvqpvap rpealakspc pspgirrgse nssseggalr
      601 rgpyrrakse msesrqgrgs ageeeeslai lrrhvmsell dterayveel lcvlegyaae
      661 mdnplmahll stglhnkkdv lfgnmeeiyh fhnriflrel enytdcpelv grcflermed
      721 fqiyekycqn kprseslwrq csdcpffqec qrkldhklsl dsyllkpvqr itkyqlllke
      781 mlkysrnceg aedlqealss ilgilkavnd smhliaitgy dgnlgdlgkl lmqgsfsvwt
      841 dhkrghtkvk elarfkpmqr hlflhekavl fckkreenge gyekapsysy kqslnmaavg
      901 itenvkgdak kfeiwynare evyivqaptp eikaawvnei rkvltsqlqa creasqhral
      961 eqsqslplpa ptstspsrgn srnikkleer ktdplslegy vssapltkpp ekgkgwskts
     1021 hsleapeddg gwssaeeqin ssdaeedggl gpkklvpgky tvvadhekgg pdalrvrsgd
     1081 vvelvqegde glwyvrdptt gkegwvpass lsvrlgpsgs aqclsssess pgsavlsnss
     1141 scseggqapf sdlqg
//
LOCUS       XP_011535792            1152 aa            linear   PRI 05-AUG-2025
DEFINITION  guanine nucleotide exchange factor DBS isoform X12 [Homo sapiens].
ACCESSION   XP_011535792
VERSION     XP_011535792.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537490.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1152
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1152
                     /product="guanine nucleotide exchange factor DBS isoform
                     X12"
                     /calculated_mol_wt=128872
     Region          17..162
                     /region_name="SEC14"
                     /note="Domain in homologues of a S. cerevisiae
                     phosphatidylinositol transfer protein (Sec14p);
                     smart00516"
                     /db_xref="CDD:214706"
     Region          293..480
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            398..403
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          573..750
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
                     (DH) domain. It appears that PH domains invariably occur
                     C-terminal to RhoGEF/DH domains; cd00160"
                     /db_xref="CDD:238091"
     Site            order(579,583,680,702..703,706..707,709..710,713..714,
                     717..718,721,746,750)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          757..888
                     /region_name="PH_Dbs"
                     /note="DBL's big sister protein pleckstrin homology (PH)
                     domain; cd01227"
                     /db_xref="CDD:269934"
     Site            order(827,829)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:269934"
     Region          1056..1109
                     /region_name="SH3_DBS"
                     /note="Src homology 3 domain of DBL's Big Sister (DBS), a
                     guanine nucleotide exchange factor; cd11857"
                     /db_xref="CDD:212791"
     Site            order(1061,1063,1066,1070,1088..1089,1104,1106..1107)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212791"
     CDS             1..1152
                     /gene="MCF2L"
                     /gene_synonym="ARHGEF14; DBS; OST"
                     /coded_by="XM_011537490.2:650..4108"
                     /db_xref="GeneID:23263"
                     /db_xref="HGNC:HGNC:14576"
                     /db_xref="MIM:609499"
ORIGIN      
        1 mhqdivplca adiqdqlkkr faylsggrgq dgspvitfpd ypafseipdk efqnvmtylt
       61 sipslqdagi gfilvidrrr dkwtsvkasv lriaasfpan lqlvlvlrpt gffqrtlsdi
      121 afkfnrddfk mkvpvimlss vpdlhgyidk sqltedlggt ldychsrwlc qrtaiesfal
      181 mvkqtaqmlq sfgtelaete lpndvqstss vlcahtekkd kakedlrlal keghsvlesl
      241 relqaegsep svnqdqldnq atvqrllaql neteaafdef wakhqqkleq clqlrhfeqg
      301 frevkailda asqkiatftd ignslahveh llrdlasfee ksgvaverar alsldgeqli
      361 gnkhyavdsi rpkcqelrhl cdqfsaeiar rrgllsksle lhrrletsmk wcdegiylla
      421 sqpvdkcqsq dgaeaalqei ekfletgaen kiqelnaiyk eyesilnqdl mehvrkvfqk
      481 qasmeevfhr rqaslkklaa rqtrpvqpva prpealaksp cpspgirrgs enssseggal
      541 rrgpyrraks emsesrqgrg sageeeesla ilrrhvmsel ldterayvee llcvlegyaa
      601 emdnplmahl lstglhnkkd vlfgnmeeiy hfhnriflre lenytdcpel vgrcflerme
      661 dfqiyekycq nkprseslwr qcsdcpffqe cqrkldhkls ldsyllkpvq ritkyqlllk
      721 emlkysrnce gaedlqeals silgilkavn dsmhliaitg ydgnlgdlgk llmqgsfsvw
      781 tdhkrghtkv kelarfkpmq rhlflhekav lfckkreeng egyekapsys ykqslnmaav
      841 gitenvkgda kkfeiwynar eevyivqapt peikaawvne irkvltsqlq acreasqhra
      901 leqsqslplp aptstspsrg nsrnikklee rktdplsleg yvssapltkp pekgkddtvt
      961 ssasessals rkrftlqgfa nlkgqkaspt spdkkakrhe vksdptpfgv rgwsktshsl
     1021 eapeddggws saeeqinssd aeedgglgpk klvpgkytvv adhekggpda lrvrsgdvve
     1081 lvqegdeglw yvrdpttgke gwvpasslsv rlgpsgsaqc lsssesspgs avlsnssscs
     1141 eggqapfsdl qg
//
LOCUS       XP_011535793            1143 aa            linear   PRI 05-AUG-2025
DEFINITION  guanine nucleotide exchange factor DBS isoform X13 [Homo sapiens].
ACCESSION   XP_011535793
VERSION     XP_011535793.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537491.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1143
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1143
                     /product="guanine nucleotide exchange factor DBS isoform
                     X13"
                     /calculated_mol_wt=127777
     Region          <62..153
                     /region_name="SEC14"
                     /note="Domain in homologues of a S. cerevisiae
                     phosphatidylinositol transfer protein (Sec14p);
                     smart00516"
                     /db_xref="CDD:214706"
     Region          284..471
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            389..394
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          564..741
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
                     (DH) domain. It appears that PH domains invariably occur
                     C-terminal to RhoGEF/DH domains; cd00160"
                     /db_xref="CDD:238091"
     Site            order(570,574,671,693..694,697..698,700..701,704..705,
                     708..709,712,737,741)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          748..879
                     /region_name="PH_Dbs"
                     /note="DBL's big sister protein pleckstrin homology (PH)
                     domain; cd01227"
                     /db_xref="CDD:269934"
     Site            order(818,820)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:269934"
     Region          1047..1100
                     /region_name="SH3_DBS"
                     /note="Src homology 3 domain of DBL's Big Sister (DBS), a
                     guanine nucleotide exchange factor; cd11857"
                     /db_xref="CDD:212791"
     Site            order(1052,1054,1057,1061,1079..1080,1095,1097..1098)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212791"
     CDS             1..1143
                     /gene="MCF2L"
                     /gene_synonym="ARHGEF14; DBS; OST"
                     /coded_by="XM_011537491.2:80..3511"
                     /db_xref="GeneID:23263"
                     /db_xref="HGNC:HGNC:14576"
                     /db_xref="MIM:609499"
ORIGIN      
        1 mwlsqrvlpp lpfpadawep sevlgifsqh rshattsesl twtstgtsda rtgvilqdag
       61 igfilvidrr rdkwtsvkas vlriaasfpa nlqlvlvlrp tgffqrtlsd iafkfnrddf
      121 kmkvpvimls svpdlhgyid ksqltedlgg tldychsrwl cqrtaiesfa lmvkqtaqml
      181 qsfgtelaet elpndvqsts svlcahtekk dkakedlrla lkeghsvles lrelqaegse
      241 psvnqdqldn qatvqrllaq lneteaafde fwakhqqkle qclqlrhfeq gfrevkaild
      301 aasqkiatft dignslahve hllrdlasfe eksgvavera ralsldgeql ignkhyavds
      361 irpkcqelrh lcdqfsaeia rrrgllsksl elhrrletsm kwcdegiyll asqpvdkcqs
      421 qdgaeaalqe iekfletgae nkiqelnaiy keyesilnqd lmehvrkvfq kqasmeevfh
      481 rrqaslkkla arqtrpvqpv aprpealaks pcpspgirrg sensssegga lrrgpyrrak
      541 semsesrqgr gsageeeesl ailrrhvmse lldterayve ellcvlegya aemdnplmah
      601 llstglhnkk dvlfgnmeei yhfhnriflr elenytdcpe lvgrcflerm edfqiyekyc
      661 qnkprseslw rqcsdcpffq ecqrkldhkl sldsyllkpv qritkyqlll kemlkysrnc
      721 egaedlqeal ssilgilkav ndsmhliait gydgnlgdlg kllmqgsfsv wtdhkrghtk
      781 vkelarfkpm qrhlflheka vlfckkreen gegyekapsy sykqslnmaa vgitenvkgd
      841 akkfeiwyna reevyivqap tpeikaawvn eirkvltsql qacreasqhr aleqsqslpl
      901 paptstspsr gnsrnikkle erktdplsle gyvssapltk ppekgkddtv tssasessal
      961 srkrftlqgf anlkgqkasp tspdkkakrh evksdptpfg vrgwsktshs leapeddggw
     1021 ssaeeqinss daeedgglgp kklvpgkytv vadhekggpd alrvrsgdvv elvqegdegl
     1081 wyvrdpttgk egwvpassls vrlgpsgsaq clsssesspg savlsnsssc seggqapfsd
     1141 lqg
//
LOCUS       XP_047286181            1103 aa            linear   PRI 05-AUG-2025
DEFINITION  guanine nucleotide exchange factor DBS isoform X16 [Homo sapiens].
ACCESSION   XP_047286181
VERSION     XP_047286181.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430225.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1103
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1103
                     /product="guanine nucleotide exchange factor DBS isoform
                     X16"
                     /calculated_mol_wt=123470
     Region          28..169
                     /region_name="SEC14"
                     /note="Domain in homologues of a S. cerevisiae
                     phosphatidylinositol transfer protein (Sec14p);
                     smart00516"
                     /db_xref="CDD:214706"
     Region          300..511
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            405..410
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          580..757
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
                     (DH) domain. It appears that PH domains invariably occur
                     C-terminal to RhoGEF/DH domains; cd00160"
                     /db_xref="CDD:238091"
     Site            order(586,590,687,709..710,713..714,716..717,720..721,
                     724..725,728,753,757)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          764..895
                     /region_name="PH_Dbs"
                     /note="DBL's big sister protein pleckstrin homology (PH)
                     domain; cd01227"
                     /db_xref="CDD:269934"
     Site            order(834,836)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:269934"
     Region          1007..1060
                     /region_name="SH3_DBS"
                     /note="Src homology 3 domain of DBL's Big Sister (DBS), a
                     guanine nucleotide exchange factor; cd11857"
                     /db_xref="CDD:212791"
     Site            order(1012,1014,1017,1021,1039..1040,1055,1057..1058)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212791"
     CDS             1..1103
                     /gene="MCF2L"
                     /gene_synonym="ARHGEF14; DBS; OST"
                     /coded_by="XM_047430225.1:4508..7819"
                     /db_xref="GeneID:23263"
                     /db_xref="HGNC:HGNC:14576"
                     /db_xref="MIM:609499"
ORIGIN      
        1 mvvcygrpdr ptnslcenas hkrvvltkas cpggrgqdgs pvitfpdypa fseipdkefq
       61 nvmtyltsip slqdagigfi lvidrrrdkw tsvkasvlri aasfpanlql vlvlrptgff
      121 qrtlsdiafk fnrddfkmkv pvimlssvpd lhgyidksql tedlggtldy chsrwlcqrt
      181 aiesfalmvk qtaqmlqsfg telaetelpn dvqstssvlc ahtekkdkak edlrlalkeg
      241 hsvleslrel qaegsepsvn qdqldnqatv qrllaqlnet eaafdefwak hqqkleqclq
      301 lrhfeqgfre vkaildaasq kiatftdign slahvehllr dlasfeeksg vaverarals
      361 ldgeqlignk hyavdsirpk cqelrhlcdq fsaeiarrrg llskslelhr rletsmkwcd
      421 egiyllasqp vdkcqsqdga eaalqeiekf letgaenkiq elnaiykeye silnqdlmeh
      481 vrkvfqkqas meevfhrrqa slkklaarqt rpvqpvaprp ealakspcps pgirrgsens
      541 sseggalrrg pyrraksems esrqgrgsag eeeeslailr rhvmselldt erayveellc
      601 vlegyaaemd nplmahllst glhnkkdvlf gnmeeiyhfh nriflrelen ytdcpelvgr
      661 cflermedfq iyekycqnkp rseslwrqcs dcpffqecqr kldhklslds yllkpvqrit
      721 kyqlllkeml kysrncegae dlqealssil gilkavndsm hliaitgydg nlgdlgkllm
      781 qgsfsvwtdh krghtkvkel arfkpmqrhl flhekavlfc kkreengegy ekapsysykq
      841 slnmaavgit envkgdakkf eiwynareev yivqaptpei kaawvneirk vltsqlqacr
      901 easqhraleq sqslplpapt stspsrgnsr nikkleerkt dplslegyvs sapltkppek
      961 gkgwsktshs leapeddggw ssaeeqinss daeedgglgp kklvpgkytv vadhekggpd
     1021 alrvrsgdvv elvqegdegl wyvrdpttgk egwvpassls vrlgpsgsaq clsssesspg
     1081 savlsnsssc seggqapfsd lqg
//
LOCUS       XP_016875988            1019 aa            linear   PRI 05-AUG-2025
DEFINITION  guanine nucleotide exchange factor DBS isoform X17 [Homo sapiens].
ACCESSION   XP_016875988
VERSION     XP_016875988.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020499.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XP_016875988.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1019
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1019
                     /product="guanine nucleotide exchange factor DBS isoform
                     X17"
                     /calculated_mol_wt=114646
     Region          79..224
                     /region_name="SEC14"
                     /note="Domain in homologues of a S. cerevisiae
                     phosphatidylinositol transfer protein (Sec14p);
                     smart00516"
                     /db_xref="CDD:214706"
     Region          355..566
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            460..465
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          635..812
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
                     (DH) domain. It appears that PH domains invariably occur
                     C-terminal to RhoGEF/DH domains; cd00160"
                     /db_xref="CDD:238091"
     Site            order(641,645,742,764..765,768..769,771..772,775..776,
                     779..780,783,808,812)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          819..950
                     /region_name="PH_Dbs"
                     /note="DBL's big sister protein pleckstrin homology (PH)
                     domain; cd01227"
                     /db_xref="CDD:269934"
     Site            order(889,891)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:269934"
     CDS             1..1019
                     /gene="MCF2L"
                     /gene_synonym="ARHGEF14; DBS; OST"
                     /coded_by="XM_017020499.3:68..3127"
                     /db_xref="GeneID:23263"
                     /db_xref="HGNC:HGNC:14576"
                     /db_xref="MIM:609499"
ORIGIN      
        1 mplrggagps pashgpthgp sdprtclpgr gaggmrphgr galgccglcs fytchgaagd
       61 eimhqdivpl caadiqdqlk krfaylsggr gqdgspvitf pdypafseip dkefqnvmty
      121 ltsipslqda gigfilvidr rrdkwtsvka svlriaasfp anlqlvlvlr ptgffqrtls
      181 diafkfnrdd fkmkvpviml ssvpdlhgyi dksqltedlg gtldychsrw lcqrtaiesf
      241 almvkqtaqm lqsfgtelae telpndvqst ssvlcahtek kdkakedlrl alkeghsvle
      301 slrelqaegs epsvnqdqld nqatvqrlla qlneteaafd efwakhqqkl eqclqlrhfe
      361 qgfrevkail daasqkiatf tdignslahv ehllrdlasf eeksgvaver aralsldgeq
      421 lignkhyavd sirpkcqelr hlcdqfsaei arrrgllsks lelhrrlets mkwcdegiyl
      481 lasqpvdkcq sqdgaeaalq eiekfletga enkiqelnai ykeyesilnq dlmehvrkvf
      541 qkqasmeevf hrrqaslkkl aarqtrpvqp vaprpealak spcpspgirr gsensssegg
      601 alrrgpyrra ksemsesrqg rgsageeees lailrrhvms elldterayv eellcvlegy
      661 aaemdnplma hllstglhnk kdvlfgnmee iyhfhnrifl relenytdcp elvgrcfler
      721 medfqiyeky cqnkprsesl wrqcsdcpff qecqrkldhk lsldsyllkp vqritkyqll
      781 lkemlkysrn cegaedlqea lssilgilka vndsmhliai tgydgnlgdl gkllmqgsfs
      841 vwtdhkrght kvkelarfkp mqrhlflhek avlfckkree ngegyekaps ysykqslnma
      901 avgitenvkg dakkfeiwyn areevyivqa ptpeikaawv neirkvltsq lqacreasqh
      961 raleqsqslp lpaptstsps rgnsrnikkl eerktdplsl egyvssaplt kppekgkep
//
LOCUS       XP_047286182            1016 aa            linear   PRI 05-AUG-2025
DEFINITION  guanine nucleotide exchange factor DBS isoform X18 [Homo sapiens].
ACCESSION   XP_047286182
VERSION     XP_047286182.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430226.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1016
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1016
                     /product="guanine nucleotide exchange factor DBS isoform
                     X18"
                     /calculated_mol_wt=115346
     Region          76..221
                     /region_name="SEC14"
                     /note="Domain in homologues of a S. cerevisiae
                     phosphatidylinositol transfer protein (Sec14p);
                     smart00516"
                     /db_xref="CDD:214706"
     Region          352..539
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            457..462
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          632..809
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
                     (DH) domain. It appears that PH domains invariably occur
                     C-terminal to RhoGEF/DH domains; cd00160"
                     /db_xref="CDD:238091"
     Site            order(638,642,739,761..762,765..766,768..769,772..773,
                     776..777,780,805,809)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          816..947
                     /region_name="PH_Dbs"
                     /note="DBL's big sister protein pleckstrin homology (PH)
                     domain; cd01227"
                     /db_xref="CDD:269934"
     Site            order(886,888)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:269934"
     CDS             1..1016
                     /gene="MCF2L"
                     /gene_synonym="ARHGEF14; DBS; OST"
                     /coded_by="XM_047430226.1:102..3152"
                     /db_xref="GeneID:23263"
                     /db_xref="HGNC:HGNC:14576"
                     /db_xref="MIM:609499"
ORIGIN      
        1 mfdcwrfilc krpgsnsyss pqrpneakke etdhqidvsd virlvqdtpe atamatdeim
       61 hqdivplcaa diqdqlkkrf aylsggrgqd gspvitfpdy pafseipdke fqnvmtylts
      121 ipslqdagig filvidrrrd kwtsvkasvl riaasfpanl qlvlvlrptg ffqrtlsdia
      181 fkfnrddfkm kvpvimlssv pdlhgyidks qltedlggtl dychsrwlcq rtaiesfalm
      241 vkqtaqmlqs fgtelaetel pndvqstssv lcahtekkdk akedlrlalk eghsvleslr
      301 elqaegseps vnqdqldnqa tvqrllaqln eteaafdefw akhqqkleqc lqlrhfeqgf
      361 revkaildaa sqkiatftdi gnslahvehl lrdlasfeek sgvaverara lsldgeqlig
      421 nkhyavdsir pkcqelrhlc dqfsaeiarr rgllskslel hrrletsmkw cdegiyllas
      481 qpvdkcqsqd gaeaalqeie kfletgaenk iqelnaiyke yesilnqdlm ehvrkvfqkq
      541 asmeevfhrr qaslkklaar qtrpvqpvap rpealakspc pspgirrgse nssseggalr
      601 rgpyrrakse msesrqgrgs ageeeeslai lrrhvmsell dterayveel lcvlegyaae
      661 mdnplmahll stglhnkkdv lfgnmeeiyh fhnriflrel enytdcpelv grcflermed
      721 fqiyekycqn kprseslwrq csdcpffqec qrkldhklsl dsyllkpvqr itkyqlllke
      781 mlkysrnceg aedlqealss ilgilkavnd smhliaitgy dgnlgdlgkl lmqgsfsvwt
      841 dhkrghtkvk elarfkpmqr hlflhekavl fckkreenge gyekapsysy kqslnmaavg
      901 itenvkgdak kfeiwynare evyivqaptp eikaawvnei rkvltsqlqa creasqhral
      961 eqsqslplpa ptstspsrgn srnikkleer ktdplslegy vssapltkpp ekgkep
//
LOCUS       XP_011533321            1399 aa            linear   PRI 05-AUG-2025
DEFINITION  microtubule-associated tumor suppressor candidate 2 isoform X1
            [Homo sapiens].
ACCESSION   XP_011533321
VERSION     XP_011533321.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535019.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1399
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1399
                     /product="microtubule-associated tumor suppressor
                     candidate 2 isoform X1"
                     /calculated_mol_wt=153089
     Region          <534..962
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          <802..1023
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          1020..>1353
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1399
                     /gene="MTUS2"
                     /gene_synonym="CAZIP; ICIS; KIAA0774; TIP150"
                     /coded_by="XM_011535019.4:559..4758"
                     /db_xref="GeneID:23281"
                     /db_xref="HGNC:HGNC:20595"
                     /db_xref="MIM:619358"
ORIGIN      
        1 massptkglt msvpvapkks cytqlrdnrn aarnnnesil slgdtnanqi mlevssshde
       61 sktcdlgdei gntnssepen rthfhkefhq lqgfgkgsqa gsaslkdfrl sstiqrelne
      121 ehtvergtds lqttrsiqgp slsswrnvms easldvlakr daeiprhvpk dklaktldne
      181 elrrhslera sssvaavgsl tpqhpqplsl dsreargqip gggegpqktl pdhavpaafp
      241 atdstsegks vrhpkpstse skqstpsetq tvgahvlqvc sehtshsahp epalnltlas
      301 keipskleaq lgqgkgeakl dlkyvpprrv eqegkaaqeg ylgchkeenl salegrdpcg
      361 eahpeatdal ghllnsdlhh lgvgrgncee krgvnpgeqd slhttpkqgs aslggadnqp
      421 tgkispcage klgertsssf spgdshvafi pnnltdskpl dvieeerrlg sgnkdsvmvl
      481 vfnpsvgenk tevpepldpq sgrsearesk evttsvaenr nllenadkie stsaradsvl
      541 nipaplhpet tvnmtyqptt psssfqdvsv fgmdagsplv vppptdsarl lntspkvpdk
      601 ntcpsgipkp vfthskdtps sqegmenyqv ekteertetk piimpkpkhv rpkiityirr
      661 npqalgqvda slvpvglpya pptctmplph eekaaggdlk psanlyekfk pdlqkprvfs
      721 sglmvsgikp pghpfsqmse kflqevtdhp gkeefcsppy ahyevpptfy rsamllkpql
      781 glgamsrlps aksriliasq rssasaihpp gpittatsly ssdpsgvhal sgtwfnysgs
      841 lgdlsadlkk asssnaaksn lpksglrppg ysrlpaakla afgfvrsssv ssvsstqsgd
      901 saqpeqgrpa trstfgneeq pvlkaslpsk dtpkgagrva ppasssvtap rrsllpapks
      961 tstpagtkkd aqkdqdtnkp avsspkrvaa sttklhspgy pkqrtaaarn gfppkpdpqa
     1021 reaerqlvlr lkerceqqtr qlgvaqgelk raicgfdala vatqhffrkn esalvkekel
     1081 sielanirde vafhtakcek lqkekeeler rfedevkrlg wqqqaelqel eerlqlqfea
     1141 emarlqeehg dqllsircqh qeqvedltas hdaallemen nhtvaitilq ddhdhkvqel
     1201 msthelekke leenfeklrl slqdqvdtlt fqsqslrdra rrfeealrkn teeqleiala
     1261 pyqhleedmk slkqvlemkn qqiheqekki leleklaekn iileekiqvl qqqnedlkar
     1321 idqntvvtrq lseenanlqe yveketqekk rlsrtneell wklqtgdpts piklsptspv
     1381 yrgsssgpss parvsttpr
//
LOCUS       XP_047286183            1399 aa            linear   PRI 05-AUG-2025
DEFINITION  microtubule-associated tumor suppressor candidate 2 isoform X1
            [Homo sapiens].
ACCESSION   XP_047286183
VERSION     XP_047286183.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430227.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 6% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1399
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1399
                     /product="microtubule-associated tumor suppressor
                     candidate 2 isoform X1"
                     /calculated_mol_wt=153089
     Region          <534..962
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          <802..1023
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          1020..>1353
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1399
                     /gene="MTUS2"
                     /gene_synonym="CAZIP; ICIS; KIAA0774; TIP150"
                     /coded_by="XM_047430227.1:609..4808"
                     /db_xref="GeneID:23281"
                     /db_xref="HGNC:HGNC:20595"
                     /db_xref="MIM:619358"
ORIGIN      
        1 massptkglt msvpvapkks cytqlrdnrn aarnnnesil slgdtnanqi mlevssshde
       61 sktcdlgdei gntnssepen rthfhkefhq lqgfgkgsqa gsaslkdfrl sstiqrelne
      121 ehtvergtds lqttrsiqgp slsswrnvms easldvlakr daeiprhvpk dklaktldne
      181 elrrhslera sssvaavgsl tpqhpqplsl dsreargqip gggegpqktl pdhavpaafp
      241 atdstsegks vrhpkpstse skqstpsetq tvgahvlqvc sehtshsahp epalnltlas
      301 keipskleaq lgqgkgeakl dlkyvpprrv eqegkaaqeg ylgchkeenl salegrdpcg
      361 eahpeatdal ghllnsdlhh lgvgrgncee krgvnpgeqd slhttpkqgs aslggadnqp
      421 tgkispcage klgertsssf spgdshvafi pnnltdskpl dvieeerrlg sgnkdsvmvl
      481 vfnpsvgenk tevpepldpq sgrsearesk evttsvaenr nllenadkie stsaradsvl
      541 nipaplhpet tvnmtyqptt psssfqdvsv fgmdagsplv vppptdsarl lntspkvpdk
      601 ntcpsgipkp vfthskdtps sqegmenyqv ekteertetk piimpkpkhv rpkiityirr
      661 npqalgqvda slvpvglpya pptctmplph eekaaggdlk psanlyekfk pdlqkprvfs
      721 sglmvsgikp pghpfsqmse kflqevtdhp gkeefcsppy ahyevpptfy rsamllkpql
      781 glgamsrlps aksriliasq rssasaihpp gpittatsly ssdpsgvhal sgtwfnysgs
      841 lgdlsadlkk asssnaaksn lpksglrppg ysrlpaakla afgfvrsssv ssvsstqsgd
      901 saqpeqgrpa trstfgneeq pvlkaslpsk dtpkgagrva ppasssvtap rrsllpapks
      961 tstpagtkkd aqkdqdtnkp avsspkrvaa sttklhspgy pkqrtaaarn gfppkpdpqa
     1021 reaerqlvlr lkerceqqtr qlgvaqgelk raicgfdala vatqhffrkn esalvkekel
     1081 sielanirde vafhtakcek lqkekeeler rfedevkrlg wqqqaelqel eerlqlqfea
     1141 emarlqeehg dqllsircqh qeqvedltas hdaallemen nhtvaitilq ddhdhkvqel
     1201 msthelekke leenfeklrl slqdqvdtlt fqsqslrdra rrfeealrkn teeqleiala
     1261 pyqhleedmk slkqvlemkn qqiheqekki leleklaekn iileekiqvl qqqnedlkar
     1321 idqntvvtrq lseenanlqe yveketqekk rlsrtneell wklqtgdpts piklsptspv
     1381 yrgsssgpss parvsttpr
//
LOCUS       XP_047286184            1399 aa            linear   PRI 05-AUG-2025
DEFINITION  microtubule-associated tumor suppressor candidate 2 isoform X1
            [Homo sapiens].
ACCESSION   XP_047286184
VERSION     XP_047286184.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430228.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1399
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1399
                     /product="microtubule-associated tumor suppressor
                     candidate 2 isoform X1"
                     /calculated_mol_wt=153089
     Region          <534..962
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          <802..1023
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          1020..>1353
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1399
                     /gene="MTUS2"
                     /gene_synonym="CAZIP; ICIS; KIAA0774; TIP150"
                     /coded_by="XM_047430228.1:486..4685"
                     /db_xref="GeneID:23281"
                     /db_xref="HGNC:HGNC:20595"
                     /db_xref="MIM:619358"
ORIGIN      
        1 massptkglt msvpvapkks cytqlrdnrn aarnnnesil slgdtnanqi mlevssshde
       61 sktcdlgdei gntnssepen rthfhkefhq lqgfgkgsqa gsaslkdfrl sstiqrelne
      121 ehtvergtds lqttrsiqgp slsswrnvms easldvlakr daeiprhvpk dklaktldne
      181 elrrhslera sssvaavgsl tpqhpqplsl dsreargqip gggegpqktl pdhavpaafp
      241 atdstsegks vrhpkpstse skqstpsetq tvgahvlqvc sehtshsahp epalnltlas
      301 keipskleaq lgqgkgeakl dlkyvpprrv eqegkaaqeg ylgchkeenl salegrdpcg
      361 eahpeatdal ghllnsdlhh lgvgrgncee krgvnpgeqd slhttpkqgs aslggadnqp
      421 tgkispcage klgertsssf spgdshvafi pnnltdskpl dvieeerrlg sgnkdsvmvl
      481 vfnpsvgenk tevpepldpq sgrsearesk evttsvaenr nllenadkie stsaradsvl
      541 nipaplhpet tvnmtyqptt psssfqdvsv fgmdagsplv vppptdsarl lntspkvpdk
      601 ntcpsgipkp vfthskdtps sqegmenyqv ekteertetk piimpkpkhv rpkiityirr
      661 npqalgqvda slvpvglpya pptctmplph eekaaggdlk psanlyekfk pdlqkprvfs
      721 sglmvsgikp pghpfsqmse kflqevtdhp gkeefcsppy ahyevpptfy rsamllkpql
      781 glgamsrlps aksriliasq rssasaihpp gpittatsly ssdpsgvhal sgtwfnysgs
      841 lgdlsadlkk asssnaaksn lpksglrppg ysrlpaakla afgfvrsssv ssvsstqsgd
      901 saqpeqgrpa trstfgneeq pvlkaslpsk dtpkgagrva ppasssvtap rrsllpapks
      961 tstpagtkkd aqkdqdtnkp avsspkrvaa sttklhspgy pkqrtaaarn gfppkpdpqa
     1021 reaerqlvlr lkerceqqtr qlgvaqgelk raicgfdala vatqhffrkn esalvkekel
     1081 sielanirde vafhtakcek lqkekeeler rfedevkrlg wqqqaelqel eerlqlqfea
     1141 emarlqeehg dqllsircqh qeqvedltas hdaallemen nhtvaitilq ddhdhkvqel
     1201 msthelekke leenfeklrl slqdqvdtlt fqsqslrdra rrfeealrkn teeqleiala
     1261 pyqhleedmk slkqvlemkn qqiheqekki leleklaekn iileekiqvl qqqnedlkar
     1321 idqntvvtrq lseenanlqe yveketqekk rlsrtneell wklqtgdpts piklsptspv
     1381 yrgsssgpss parvsttpr
//
LOCUS       XP_047286185            1378 aa            linear   PRI 05-AUG-2025
DEFINITION  microtubule-associated tumor suppressor candidate 2 isoform X2
            [Homo sapiens].
ACCESSION   XP_047286185
VERSION     XP_047286185.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430229.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1378
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1378
                     /product="microtubule-associated tumor suppressor
                     candidate 2 isoform X2"
                     /calculated_mol_wt=150967
     Region          <534..941
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          999..>1332
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1378
                     /gene="MTUS2"
                     /gene_synonym="CAZIP; ICIS; KIAA0774; TIP150"
                     /coded_by="XM_047430229.1:486..4622"
                     /db_xref="GeneID:23281"
                     /db_xref="HGNC:HGNC:20595"
                     /db_xref="MIM:619358"
ORIGIN      
        1 massptkglt msvpvapkks cytqlrdnrn aarnnnesil slgdtnanqi mlevssshde
       61 sktcdlgdei gntnssepen rthfhkefhq lqgfgkgsqa gsaslkdfrl sstiqrelne
      121 ehtvergtds lqttrsiqgp slsswrnvms easldvlakr daeiprhvpk dklaktldne
      181 elrrhslera sssvaavgsl tpqhpqplsl dsreargqip gggegpqktl pdhavpaafp
      241 atdstsegks vrhpkpstse skqstpsetq tvgahvlqvc sehtshsahp epalnltlas
      301 keipskleaq lgqgkgeakl dlkyvpprrv eqegkaaqeg ylgchkeenl salegrdpcg
      361 eahpeatdal ghllnsdlhh lgvgrgncee krgvnpgeqd slhttpkqgs aslggadnqp
      421 tgkispcage klgertsssf spgdshvafi pnnltdskpl dvieeerrlg sgnkdsvmvl
      481 vfnpsvgenk tevpepldpq sgrsearesk evttsvaenr nllenadkie stsaradsvl
      541 nipaplhpet tvnmtyqptt psssfqdvsv fgmdagsplv vppptdsarl lntspkvpdk
      601 ntcpsgipkp vfthskdtps sqegmenyqv ekteertetk piimpkpkhv rpkiityirr
      661 npqalgqvda slvpvglpya pptctmplph eekaaggdlk psanlyekfk pdlqkprvfs
      721 sglmvsgikp pghpfsqmse kflqevtdhp gkeefcsppy ahyevpptfy rsamllkpql
      781 glgamsrlps aksriliasq rssasaihpp gpittatsly ssdpsdlkka sssnaaksnl
      841 pksglrppgy srlpaaklaa fgfvrsssvs svsstqsgds aqpeqgrpat rstfgneeqp
      901 vlkaslpskd tpkgagrvap passsvtapr rsllpapkst stpagtkkda qkdqdtnkpa
      961 vsspkrvaas ttklhspgyp kqrtaaarng fppkpdpqar eaerqlvlrl kerceqqtrq
     1021 lgvaqgelkr aicgfdalav atqhffrkne salvkekels ielanirdev afhtakcekl
     1081 qkekeelerr fedevkrlgw qqqaelqele erlqlqfeae marlqeehgd qllsircqhq
     1141 eqvedltash daallemenn htvaitilqd dhdhkvqelm sthelekkel eenfeklrls
     1201 lqdqvdtltf qsqslrdrar rfeealrknt eeqleialap yqhleedmks lkqvlemknq
     1261 qiheqekkil eleklaekni ileekiqvlq qqnedlkari dqntvvtrql seenanlqey
     1321 veketqekkr lsrtneellw klqtgdptsp iklsptspvy rgsssgpssp arvsttpr
//
LOCUS       XP_016875989            1082 aa            linear   PRI 05-AUG-2025
DEFINITION  microtubule-associated tumor suppressor candidate 2 isoform X3
            [Homo sapiens].
ACCESSION   XP_016875989
VERSION     XP_016875989.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020500.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1082
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1082
                     /product="microtubule-associated tumor suppressor
                     candidate 2 isoform X3"
                     /calculated_mol_wt=115934
     Region          <802..1023
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..1082
                     /gene="MTUS2"
                     /gene_synonym="CAZIP; ICIS; KIAA0774; TIP150"
                     /coded_by="XM_017020500.3:3915..7163"
                     /db_xref="GeneID:23281"
                     /db_xref="HGNC:HGNC:20595"
                     /db_xref="MIM:619358"
ORIGIN      
        1 massptkglt msvpvapkks cytqlrdnrn aarnnnesil slgdtnanqi mlevssshde
       61 sktcdlgdei gntnssepen rthfhkefhq lqgfgkgsqa gsaslkdfrl sstiqrelne
      121 ehtvergtds lqttrsiqgp slsswrnvms easldvlakr daeiprhvpk dklaktldne
      181 elrrhslera sssvaavgsl tpqhpqplsl dsreargqip gggegpqktl pdhavpaafp
      241 atdstsegks vrhpkpstse skqstpsetq tvgahvlqvc sehtshsahp epalnltlas
      301 keipskleaq lgqgkgeakl dlkyvpprrv eqegkaaqeg ylgchkeenl salegrdpcg
      361 eahpeatdal ghllnsdlhh lgvgrgncee krgvnpgeqd slhttpkqgs aslggadnqp
      421 tgkispcage klgertsssf spgdshvafi pnnltdskpl dvieeerrlg sgnkdsvmvl
      481 vfnpsvgenk tevpepldpq sgrsearesk evttsvaenr nllenadkie stsaradsvl
      541 nipaplhpet tvnmtyqptt psssfqdvsv fgmdagsplv vppptdsarl lntspkvpdk
      601 ntcpsgipkp vfthskdtps sqegmenyqv ekteertetk piimpkpkhv rpkiityirr
      661 npqalgqvda slvpvglpya pptctmplph eekaaggdlk psanlyekfk pdlqkprvfs
      721 sglmvsgikp pghpfsqmse kflqevtdhp gkeefcsppy ahyevpptfy rsamllkpql
      781 glgamsrlps aksriliasq rssasaihpp gpittatsly ssdpsgvhal sgtwfnysgs
      841 lgdlsadlkk asssnaaksn lpksglrppg ysrlpaakla afgfvrsssv ssvsstqsgd
      901 saqpeqgrpa trstfgneeq pvlkaslpsk dtpkgagrva ppasssvtap rrsllpapks
      961 tstpagtkkd aqkdqdtnkp avsspkrvaa sttklhspgy pkqrtaaarn gfppkpdpqa
     1021 reaerqlvlr lkerceqqtr qlgvaqgelk raicgfdala vatqhffrki hmyviinrss
     1081 se
//
LOCUS       XP_016875990             947 aa            linear   PRI 05-AUG-2025
DEFINITION  microtubule-associated tumor suppressor candidate 2 isoform X4
            [Homo sapiens].
ACCESSION   XP_016875990
VERSION     XP_016875990.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020501.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..947
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..947
                     /product="microtubule-associated tumor suppressor
                     candidate 2 isoform X4"
                     /calculated_mol_wt=101498
     CDS             1..947
                     /gene="MTUS2"
                     /gene_synonym="CAZIP; ICIS; KIAA0774; TIP150"
                     /coded_by="XM_017020501.3:3914..6757"
                     /db_xref="GeneID:23281"
                     /db_xref="HGNC:HGNC:20595"
                     /db_xref="MIM:619358"
ORIGIN      
        1 massptkglt msvpvapkks cytqlrdnrn aarnnnesil slgdtnanqi mlevssshde
       61 sktcdlgdei gntnssepen rthfhkefhq lqgfgkgsqa gsaslkdfrl sstiqrelne
      121 ehtvergtds lqttrsiqgp slsswrnvms easldvlakr daeiprhvpk dklaktldne
      181 elrrhslera sssvaavgsl tpqhpqplsl dsreargqip gggegpqktl pdhavpaafp
      241 atdstsegks vrhpkpstse skqstpsetq tvgahvlqvc sehtshsahp epalnltlas
      301 keipskleaq lgqgkgeakl dlkyvpprrv eqegkaaqeg ylgchkeenl salegrdpcg
      361 eahpeatdal ghllnsdlhh lgvgrgncee krgvnpgeqd slhttpkqgs aslggadnqp
      421 tgkispcage klgertsssf spgdshvafi pnnltdskpl dvieeerrlg sgnkdsvmvl
      481 vfnpsvgenk tevpepldpq sgrsearesk evttsvaenr nllenadkie stsaradsvl
      541 nipaplhpet tvnmtyqptt psssfqdvsv fgmdagsplv vppptdsarl lntspkvpdk
      601 ntcpsgipkp vfthskdtps sqegmenyqv ekteertetk piimpkpkhv rpkiityirr
      661 npqalgqvda slvpvglpya pptctmplph eekaaggdlk psanlyekfk pdlqkprvfs
      721 sglmvsgikp pghpfsqmse kflqevtdhp gkeefcsppy ahyevpptfy rsamllkpql
      781 glgamsrlps aksriliasq rssasaihpp gpittatsly ssdpsgvhal sgtwfnysgs
      841 lgdlsadlkk asssnaaksn lpksglrppg ysrlpaakla afgfvrsssv ssvsstqsgd
      901 saqpeqgrpa trisskwnha icglfclasf tnaseahlsc srfnlwe
//
LOCUS       XP_024305103             575 aa            linear   PRI 05-AUG-2025
DEFINITION  microtubule-associated tumor suppressor candidate 2 isoform X5
            [Homo sapiens].
ACCESSION   XP_024305103
VERSION     XP_024305103.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449335.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..575
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..575
                     /product="microtubule-associated tumor suppressor
                     candidate 2 isoform X5"
                     /calculated_mol_wt=64989
     Region          37..>182
                     /region_name="PHA03381"
                     /note="tegument protein VP22; Provisional"
                     /db_xref="CDD:177618"
     Region          196..>529
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..575
                     /gene="MTUS2"
                     /gene_synonym="CAZIP; ICIS; KIAA0774; TIP150"
                     /coded_by="XM_024449335.2:123..1850"
                     /db_xref="GeneID:23281"
                     /db_xref="HGNC:HGNC:20595"
                     /db_xref="MIM:619358"
ORIGIN      
        1 mlqnpisrnl vsvlpdthvs rqpnwrhlal sgapaspqsp apspgtvhsq sragqppefh
       61 lngtmqyvvs fvwhlslmll rliclvagst fgneeqpvlk aslpskdtpk gagrvappas
      121 ssvtaprrsl lpapkststp agtkkdaqkd qdtnkpavss pkrvaasttk lhspgypkqr
      181 taaarngfpp kpdpqareae rqlvlrlker ceqqtrqlgv aqgelkraic gfdalavatq
      241 hffrknesal vkekelsiel anirdevafh takceklqke keelerrfed evkrlgwqqq
      301 aelqeleerl qlqfeaemar lqeehgdqll sircqhqeqv edltashdaa llemennhtv
      361 aitilqddhd hkvqelmsth elekkeleen feklrlslqd qvdtltfqsq slrdrarrfe
      421 ealrknteeq leialapyqh leedmkslkq vlemknqqih eqekkilele klaekniile
      481 ekiqvlqqqn edlkaridqn tvvtrqlsee nanlqeyvek etqekkrlsr tneellwklq
      541 tgdptspikl sptspvyrgs ssgpssparv sttpr
//
LOCUS       XP_011533324             575 aa            linear   PRI 05-AUG-2025
DEFINITION  microtubule-associated tumor suppressor candidate 2 isoform X5
            [Homo sapiens].
ACCESSION   XP_011533324
VERSION     XP_011533324.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535022.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..575
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..575
                     /product="microtubule-associated tumor suppressor
                     candidate 2 isoform X5"
                     /calculated_mol_wt=64989
     Region          37..>182
                     /region_name="PHA03381"
                     /note="tegument protein VP22; Provisional"
                     /db_xref="CDD:177618"
     Region          196..>529
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..575
                     /gene="MTUS2"
                     /gene_synonym="CAZIP; ICIS; KIAA0774; TIP150"
                     /coded_by="XM_011535022.2:121..1848"
                     /db_xref="GeneID:23281"
                     /db_xref="HGNC:HGNC:20595"
                     /db_xref="MIM:619358"
ORIGIN      
        1 mlqnpisrnl vsvlpdthvs rqpnwrhlal sgapaspqsp apspgtvhsq sragqppefh
       61 lngtmqyvvs fvwhlslmll rliclvagst fgneeqpvlk aslpskdtpk gagrvappas
      121 ssvtaprrsl lpapkststp agtkkdaqkd qdtnkpavss pkrvaasttk lhspgypkqr
      181 taaarngfpp kpdpqareae rqlvlrlker ceqqtrqlgv aqgelkraic gfdalavatq
      241 hffrknesal vkekelsiel anirdevafh takceklqke keelerrfed evkrlgwqqq
      301 aelqeleerl qlqfeaemar lqeehgdqll sircqhqeqv edltashdaa llemennhtv
      361 aitilqddhd hkvqelmsth elekkeleen feklrlslqd qvdtltfqsq slrdrarrfe
      421 ealrknteeq leialapyqh leedmkslkq vlemknqqih eqekkilele klaekniile
      481 ekiqvlqqqn edlkaridqn tvvtrqlsee nanlqeyvek etqekkrlsr tneellwklq
      541 tgdptspikl sptspvyrgs ssgpssparv sttpr
//
LOCUS       XP_016875992            2140 aa            linear   PRI 05-AUG-2025
DEFINITION  dedicator of cytokinesis protein 9 isoform X1 [Homo sapiens].
ACCESSION   XP_016875992
VERSION     XP_016875992.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020503.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2140
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..2140
                     /product="dedicator of cytokinesis protein 9 isoform X1"
                     /calculated_mol_wt=244564
     Region          56..166
                     /region_name="DOCK_C-D_N"
                     /note="Dedicator of cytokinesis C/D, N terminal;
                     pfam11878"
                     /db_xref="CDD:463380"
     Region          180..303
                     /region_name="PH_DOCK-D"
                     /note="Dedicator of cytokinesis-D subfamily Pleckstrin
                     homology (PH) domain; cd13267"
                     /db_xref="CDD:270087"
     Region          649..838
                     /region_name="C2_Dock-D"
                     /note="C2 domains found in Dedicator Of CytoKinesis (Dock)
                     class C proteins; cd08697"
                     /db_xref="CDD:176079"
     Region          1645..2096
                     /region_name="DHR2_DOCK9"
                     /note="Dock Homology Region 2, a GEF domain, of Class D
                     Dedicator of Cytokinesis 9; cd11698"
                     /db_xref="CDD:212571"
     Site            order(1772,1782,1784..1785,1787..1788,1791..1792,
                     1794..1795,1798..1799)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            order(1806..1809,1811,1854..1855,1857..1860,1862..1863,
                     1882..1884,1901,1903,1932,1934,1941..1942,1948,1987..1988,
                     1991,2005,2007,2011,2014..2016,2019..2022,2024..2025,2028,
                     2056,2074..2075,2077..2078,2081)
                     /site_type="other"
                     /note="Cdc42 binding site [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            2019..2024
                     /site_type="other"
                     /note="nucleotide sensor"
                     /db_xref="CDD:212571"
     CDS             1..2140
                     /gene="DOCK9"
                     /gene_synonym="ZIZ1; ZIZIMIN1"
                     /coded_by="XM_017020503.2:16..6438"
                     /db_xref="GeneID:23348"
                     /db_xref="HGNC:HGNC:14132"
                     /db_xref="MIM:607325"
ORIGIN      
        1 mgtyllvalp cfnhqpgiwf ltitqmkafq nwknfrtsrq pccllsstsf rfkakpklie
       61 pldyenvivq kktqilndcl remllfpydd fqtailrrqg ryicstvpak aeeeaqslfv
      121 teciktynsd whlvnykyed ysgefrqlpn kvvkldklpv hvyevdeevd kdedaaslgs
      181 qkggitkhgw lykgnmnsai svtmrsfkrr ffhliqlgdg synlnfykde kiskepkgsi
      241 fldscmgvvq nnkvrrfafe lkmqdkssyl laadseveme ewitilnkil qlnfeaamqe
      301 krngdshedd eqsklegsgs gldsylpela ksareaeikl ksesrvklfy ldpdaqkldf
      361 ssaepevksf eekfgkrilv kcndlsfnlq ccvaeneegp ttnvepffvt lslfdikynr
      421 kisadfhvdl nhfsvrqmla ttspalmngs gqspsvlkgi lheaamqypk qgifsvtcph
      481 pdiflvarie kvlqgsithc aepymkssds skvaqkvlkn akqacqrlgq yrmpfawaar
      541 tlfkdasgnl dknarfsaiy rqdsnklsnd dmlklladfr kpekmaklpv ilgnlditid
      601 nvssdfpnyv nssyiptkqf etcsktpitf eveefvpcip khtqpytiyt nhlyvypkyl
      661 kydsqksfak arniaicief kdsdeedsqp lkciygrpgg pvftrsafaa vlhhhqnpef
      721 ydeikielpt qlhekhhlll tffhvscdns skgstkkrdv vetqvgyswl pllkdgrvvt
      781 seqhipvsan lpsgylgyqe lgmgrhygpe ikwvdggkpl lkisthlvst vytqdqhlhn
      841 ffqycqktes gaqalgnelv kylkslhame ghvmiaflpt ilnqlfrvlt ratqeevavn
      901 vtrviihvva qcheeglesh lrsyvkyayk aepyvaseyk tvheeltksm ttilkpsadf
      961 ltsnkllkys wfffdvliks maqhliensk vkllrnqrfp asyhhavetv vnmlmphitq
     1021 kfrdnpeask nanhslavfi krcftfmdrg fvfkqinnyi scfapgdpkt lfeykfeflr
     1081 vvcnhehyip lnlpmpfgkg riqryqdlql dysltdefcr nhflvglllr evgtalqefr
     1141 evrliaisvl knllikhsfd dryasrshqa riatlylplf gllienvqri nvrdvspfpv
     1201 nagmtvkdes lalpavnplv tpqkgstldn slhkdllgai sgiaspytts tpninsvrna
     1261 dsrgslistd sgnslperns eksnsldkhq qsstlgnsvv rcdkldqsei ksllmcflyi
     1321 lksmsddalf tywnkastse lmdfftisev clhqfqymgk ryiarnqegl gpivhdrksq
     1381 tlpvsrnrtg mmharlqqlg sldnsltfnh syghsdadvl hqslleania tevcltaldt
     1441 lslftlafkn qlladhghnp lmkkvfdvyl cflqkhqset alknvftalr sliykfpstf
     1501 yegradmcaa lcyeilkccn sklssirtea sqllyflmrn nfdytgkksf vrthlqviis
     1561 vsqliadvvg iggtrfqqsl siinncansd rlikhtsfss dvkdltkrir tvlmataqmk
     1621 ehendpemlv dlqyslaksy astpelrktw ldsmarihvk ngdlseaamc yvhvtalvae
     1681 yltrkeavqw eppllphshs aclrrsrggv frqgctafrv itpnideeas mmedvgmqdv
     1741 hfnedvlmel leqcadglwk aeryeliadi ykliipiyek rrdferlahl ydtlhraysk
     1801 vtevmhsgrr llgtyfrvaf fgqaaqyqft dsetdvegff ededgkeyiy kepkltplse
     1861 isqrllklys dkfgsenvkm iqdsgkvnpk dldskyayiq vthvipffde kelqerktef
     1921 ershnirrfm fempftqtgk rqggveeqck rrtiltaihc fpyvkkripv myqhhtdlnp
     1981 ievaidemsk kvaelrqlcs saevdmiklq lklqgsvsvq vnagplayar aflddtntkr
     2041 ypdnkvkllk evfrqfveac gqalavnerl ikedqleyqe emkanyrema kelseimheq
     2101 icpleektsv lpnslhifna isgtptstmv hgmtssssvv
//
LOCUS       XP_016875993            2126 aa            linear   PRI 05-AUG-2025
DEFINITION  dedicator of cytokinesis protein 9 isoform X2 [Homo sapiens].
ACCESSION   XP_016875993
VERSION     XP_016875993.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020504.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2126
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..2126
                     /product="dedicator of cytokinesis protein 9 isoform X2"
                     /calculated_mol_wt=242979
     Region          56..166
                     /region_name="DOCK_C-D_N"
                     /note="Dedicator of cytokinesis C/D, N terminal;
                     pfam11878"
                     /db_xref="CDD:463380"
     Region          180..303
                     /region_name="PH_DOCK-D"
                     /note="Dedicator of cytokinesis-D subfamily Pleckstrin
                     homology (PH) domain; cd13267"
                     /db_xref="CDD:270087"
     Region          649..838
                     /region_name="C2_Dock-D"
                     /note="C2 domains found in Dedicator Of CytoKinesis (Dock)
                     class C proteins; cd08697"
                     /db_xref="CDD:176079"
     Region          1645..2082
                     /region_name="DHR2_DOCK9"
                     /note="Dock Homology Region 2, a GEF domain, of Class D
                     Dedicator of Cytokinesis 9; cd11698"
                     /db_xref="CDD:212571"
     Site            order(1772,1782,1784..1785,1787..1788,1791..1792,
                     1794..1795,1798..1799)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            order(1806..1809,1811,1840..1841,1843..1846,1848..1849,
                     1868..1870,1887,1889,1918,1920,1927..1928,1934,1973..1974,
                     1977,1991,1993,1997,2000..2002,2005..2008,2010..2011,2014,
                     2042,2060..2061,2063..2064,2067)
                     /site_type="other"
                     /note="Cdc42 binding site [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            2005..2010
                     /site_type="other"
                     /note="nucleotide sensor"
                     /db_xref="CDD:212571"
     CDS             1..2126
                     /gene="DOCK9"
                     /gene_synonym="ZIZ1; ZIZIMIN1"
                     /coded_by="XM_017020504.2:16..6396"
                     /db_xref="GeneID:23348"
                     /db_xref="HGNC:HGNC:14132"
                     /db_xref="MIM:607325"
ORIGIN      
        1 mgtyllvalp cfnhqpgiwf ltitqmkafq nwknfrtsrq pccllsstsf rfkakpklie
       61 pldyenvivq kktqilndcl remllfpydd fqtailrrqg ryicstvpak aeeeaqslfv
      121 teciktynsd whlvnykyed ysgefrqlpn kvvkldklpv hvyevdeevd kdedaaslgs
      181 qkggitkhgw lykgnmnsai svtmrsfkrr ffhliqlgdg synlnfykde kiskepkgsi
      241 fldscmgvvq nnkvrrfafe lkmqdkssyl laadseveme ewitilnkil qlnfeaamqe
      301 krngdshedd eqsklegsgs gldsylpela ksareaeikl ksesrvklfy ldpdaqkldf
      361 ssaepevksf eekfgkrilv kcndlsfnlq ccvaeneegp ttnvepffvt lslfdikynr
      421 kisadfhvdl nhfsvrqmla ttspalmngs gqspsvlkgi lheaamqypk qgifsvtcph
      481 pdiflvarie kvlqgsithc aepymkssds skvaqkvlkn akqacqrlgq yrmpfawaar
      541 tlfkdasgnl dknarfsaiy rqdsnklsnd dmlklladfr kpekmaklpv ilgnlditid
      601 nvssdfpnyv nssyiptkqf etcsktpitf eveefvpcip khtqpytiyt nhlyvypkyl
      661 kydsqksfak arniaicief kdsdeedsqp lkciygrpgg pvftrsafaa vlhhhqnpef
      721 ydeikielpt qlhekhhlll tffhvscdns skgstkkrdv vetqvgyswl pllkdgrvvt
      781 seqhipvsan lpsgylgyqe lgmgrhygpe ikwvdggkpl lkisthlvst vytqdqhlhn
      841 ffqycqktes gaqalgnelv kylkslhame ghvmiaflpt ilnqlfrvlt ratqeevavn
      901 vtrviihvva qcheeglesh lrsyvkyayk aepyvaseyk tvheeltksm ttilkpsadf
      961 ltsnkllkys wfffdvliks maqhliensk vkllrnqrfp asyhhavetv vnmlmphitq
     1021 kfrdnpeask nanhslavfi krcftfmdrg fvfkqinnyi scfapgdpkt lfeykfeflr
     1081 vvcnhehyip lnlpmpfgkg riqryqdlql dysltdefcr nhflvglllr evgtalqefr
     1141 evrliaisvl knllikhsfd dryasrshqa riatlylplf gllienvqri nvrdvspfpv
     1201 nagmtvkdes lalpavnplv tpqkgstldn slhkdllgai sgiaspytts tpninsvrna
     1261 dsrgslistd sgnslperns eksnsldkhq qsstlgnsvv rcdkldqsei ksllmcflyi
     1321 lksmsddalf tywnkastse lmdfftisev clhqfqymgk ryiarnqegl gpivhdrksq
     1381 tlpvsrnrtg mmharlqqlg sldnsltfnh syghsdadvl hqslleania tevcltaldt
     1441 lslftlafkn qlladhghnp lmkkvfdvyl cflqkhqset alknvftalr sliykfpstf
     1501 yegradmcaa lcyeilkccn sklssirtea sqllyflmrn nfdytgkksf vrthlqviis
     1561 vsqliadvvg iggtrfqqsl siinncansd rlikhtsfss dvkdltkrir tvlmataqmk
     1621 ehendpemlv dlqyslaksy astpelrktw ldsmarihvk ngdlseaamc yvhvtalvae
     1681 yltrkeavqw eppllphshs aclrrsrggv frqgctafrv itpnideeas mmedvgmqdv
     1741 hfnedvlmel leqcadglwk aeryeliadi ykliipiyek rrdferlahl ydtlhraysk
     1801 vtevmhsgrr llgtyfrvaf fgqgffeded gkeyiykepk ltplseisqr llklysdkfg
     1861 senvkmiqds gkvnpkdlds kyayiqvthv ipffdekelq erktefersh nirrfmfemp
     1921 ftqtgkrqgg veeqckrrti ltaihcfpyv kkripvmyqh htdlnpieva idemskkvae
     1981 lrqlcssaev dmiklqlklq gsvsvqvnag playarafld dtntkrypdn kvkllkevfr
     2041 qfveacgqal avnerliked qleyqeemka nyremakels eimheqicpl eektsvlpns
     2101 lhifnaisgt ptstmvhgmt ssssvv
//
LOCUS       XP_016875994            2117 aa            linear   PRI 05-AUG-2025
DEFINITION  dedicator of cytokinesis protein 9 isoform X3 [Homo sapiens].
ACCESSION   XP_016875994
VERSION     XP_016875994.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020505.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2117
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..2117
                     /product="dedicator of cytokinesis protein 9 isoform X3"
                     /calculated_mol_wt=241955
     Region          56..166
                     /region_name="DOCK_C-D_N"
                     /note="Dedicator of cytokinesis C/D, N terminal;
                     pfam11878"
                     /db_xref="CDD:463380"
     Region          180..303
                     /region_name="PH_DOCK-D"
                     /note="Dedicator of cytokinesis-D subfamily Pleckstrin
                     homology (PH) domain; cd13267"
                     /db_xref="CDD:270087"
     Region          649..838
                     /region_name="C2_Dock-D"
                     /note="C2 domains found in Dedicator Of CytoKinesis (Dock)
                     class C proteins; cd08697"
                     /db_xref="CDD:176079"
     Region          1645..2073
                     /region_name="DHR2_DOCK9"
                     /note="Dock Homology Region 2, a GEF domain, of Class D
                     Dedicator of Cytokinesis 9; cd11698"
                     /db_xref="CDD:212571"
     Site            order(1749,1759,1761..1762,1764..1765,1768..1769,
                     1771..1772,1775..1776)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            order(1783..1786,1788,1831..1832,1834..1837,1839..1840,
                     1859..1861,1878,1880,1909,1911,1918..1919,1925,1964..1965,
                     1968,1982,1984,1988,1991..1993,1996..1999,2001..2002,2005,
                     2033,2051..2052,2054..2055,2058)
                     /site_type="other"
                     /note="Cdc42 binding site [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            1996..2001
                     /site_type="other"
                     /note="nucleotide sensor"
                     /db_xref="CDD:212571"
     CDS             1..2117
                     /gene="DOCK9"
                     /gene_synonym="ZIZ1; ZIZIMIN1"
                     /coded_by="XM_017020505.2:16..6369"
                     /db_xref="GeneID:23348"
                     /db_xref="HGNC:HGNC:14132"
                     /db_xref="MIM:607325"
ORIGIN      
        1 mgtyllvalp cfnhqpgiwf ltitqmkafq nwknfrtsrq pccllsstsf rfkakpklie
       61 pldyenvivq kktqilndcl remllfpydd fqtailrrqg ryicstvpak aeeeaqslfv
      121 teciktynsd whlvnykyed ysgefrqlpn kvvkldklpv hvyevdeevd kdedaaslgs
      181 qkggitkhgw lykgnmnsai svtmrsfkrr ffhliqlgdg synlnfykde kiskepkgsi
      241 fldscmgvvq nnkvrrfafe lkmqdkssyl laadseveme ewitilnkil qlnfeaamqe
      301 krngdshedd eqsklegsgs gldsylpela ksareaeikl ksesrvklfy ldpdaqkldf
      361 ssaepevksf eekfgkrilv kcndlsfnlq ccvaeneegp ttnvepffvt lslfdikynr
      421 kisadfhvdl nhfsvrqmla ttspalmngs gqspsvlkgi lheaamqypk qgifsvtcph
      481 pdiflvarie kvlqgsithc aepymkssds skvaqkvlkn akqacqrlgq yrmpfawaar
      541 tlfkdasgnl dknarfsaiy rqdsnklsnd dmlklladfr kpekmaklpv ilgnlditid
      601 nvssdfpnyv nssyiptkqf etcsktpitf eveefvpcip khtqpytiyt nhlyvypkyl
      661 kydsqksfak arniaicief kdsdeedsqp lkciygrpgg pvftrsafaa vlhhhqnpef
      721 ydeikielpt qlhekhhlll tffhvscdns skgstkkrdv vetqvgyswl pllkdgrvvt
      781 seqhipvsan lpsgylgyqe lgmgrhygpe ikwvdggkpl lkisthlvst vytqdqhlhn
      841 ffqycqktes gaqalgnelv kylkslhame ghvmiaflpt ilnqlfrvlt ratqeevavn
      901 vtrviihvva qcheeglesh lrsyvkyayk aepyvaseyk tvheeltksm ttilkpsadf
      961 ltsnkllkys wfffdvliks maqhliensk vkllrnqrfp asyhhavetv vnmlmphitq
     1021 kfrdnpeask nanhslavfi krcftfmdrg fvfkqinnyi scfapgdpkt lfeykfeflr
     1081 vvcnhehyip lnlpmpfgkg riqryqdlql dysltdefcr nhflvglllr evgtalqefr
     1141 evrliaisvl knllikhsfd dryasrshqa riatlylplf gllienvqri nvrdvspfpv
     1201 nagmtvkdes lalpavnplv tpqkgstldn slhkdllgai sgiaspytts tpninsvrna
     1261 dsrgslistd sgnslperns eksnsldkhq qsstlgnsvv rcdkldqsei ksllmcflyi
     1321 lksmsddalf tywnkastse lmdfftisev clhqfqymgk ryiarnqegl gpivhdrksq
     1381 tlpvsrnrtg mmharlqqlg sldnsltfnh syghsdadvl hqslleania tevcltaldt
     1441 lslftlafkn qlladhghnp lmkkvfdvyl cflqkhqset alknvftalr sliykfpstf
     1501 yegradmcaa lcyeilkccn sklssirtea sqllyflmrn nfdytgkksf vrthlqviis
     1561 vsqliadvvg iggtrfqqsl siinncansd rlikhtsfss dvkdltkrir tvlmataqmk
     1621 ehendpemlv dlqyslaksy astpelrktw ldsmarihvk ngdlseaamc yvhvtalvae
     1681 yltrkgvfrq gctafrvitp nideeasmme dvgmqdvhfn edvlmelleq cadglwkaer
     1741 yeliadiykl iipiyekrrd ferlahlydt lhrayskvte vmhsgrrllg tyfrvaffgq
     1801 aaqyqftdse tdvegffede dgkeyiykep kltplseisq rllklysdkf gsenvkmiqd
     1861 sgkvnpkdld skyayiqvth vipffdekel qerktefers hnirrfmfem pftqtgkrqg
     1921 gveeqckrrt iltaihcfpy vkkripvmyq hhtdlnpiev aidemskkva elrqlcssae
     1981 vdmiklqlkl qgsvsvqvna gplayarafl ddtntkrypd nkvkllkevf rqfveacgqa
     2041 lavnerlike dqleyqeemk anyremakel seimheqicp leektsvlpn slhifnaisg
     2101 tptstmvhgm tssssvv
//
LOCUS       XP_016875995            2109 aa            linear   PRI 05-AUG-2025
DEFINITION  dedicator of cytokinesis protein 9 isoform X4 [Homo sapiens].
ACCESSION   XP_016875995
VERSION     XP_016875995.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020506.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2109
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..2109
                     /product="dedicator of cytokinesis protein 9 isoform X4"
                     /calculated_mol_wt=240896
     Region          56..166
                     /region_name="DOCK_C-D_N"
                     /note="Dedicator of cytokinesis C/D, N terminal;
                     pfam11878"
                     /db_xref="CDD:463380"
     Region          180..303
                     /region_name="PH_DOCK-D"
                     /note="Dedicator of cytokinesis-D subfamily Pleckstrin
                     homology (PH) domain; cd13267"
                     /db_xref="CDD:270087"
     Region          649..838
                     /region_name="C2_Dock-D"
                     /note="C2 domains found in Dedicator Of CytoKinesis (Dock)
                     class C proteins; cd08697"
                     /db_xref="CDD:176079"
     Region          1614..2065
                     /region_name="DHR2_DOCK9"
                     /note="Dock Homology Region 2, a GEF domain, of Class D
                     Dedicator of Cytokinesis 9; cd11698"
                     /db_xref="CDD:212571"
     Site            order(1741,1751,1753..1754,1756..1757,1760..1761,
                     1763..1764,1767..1768)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            order(1775..1778,1780,1823..1824,1826..1829,1831..1832,
                     1851..1853,1870,1872,1901,1903,1910..1911,1917,1956..1957,
                     1960,1974,1976,1980,1983..1985,1988..1991,1993..1994,1997,
                     2025,2043..2044,2046..2047,2050)
                     /site_type="other"
                     /note="Cdc42 binding site [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            1988..1993
                     /site_type="other"
                     /note="nucleotide sensor"
                     /db_xref="CDD:212571"
     CDS             1..2109
                     /gene="DOCK9"
                     /gene_synonym="ZIZ1; ZIZIMIN1"
                     /coded_by="XM_017020506.2:16..6345"
                     /db_xref="GeneID:23348"
                     /db_xref="HGNC:HGNC:14132"
                     /db_xref="MIM:607325"
ORIGIN      
        1 mgtyllvalp cfnhqpgiwf ltitqmkafq nwknfrtsrq pccllsstsf rfkakpklie
       61 pldyenvivq kktqilndcl remllfpydd fqtailrrqg ryicstvpak aeeeaqslfv
      121 teciktynsd whlvnykyed ysgefrqlpn kvvkldklpv hvyevdeevd kdedaaslgs
      181 qkggitkhgw lykgnmnsai svtmrsfkrr ffhliqlgdg synlnfykde kiskepkgsi
      241 fldscmgvvq nnkvrrfafe lkmqdkssyl laadseveme ewitilnkil qlnfeaamqe
      301 krngdshedd eqsklegsgs gldsylpela ksareaeikl ksesrvklfy ldpdaqkldf
      361 ssaepevksf eekfgkrilv kcndlsfnlq ccvaeneegp ttnvepffvt lslfdikynr
      421 kisadfhvdl nhfsvrqmla ttspalmngs gqspsvlkgi lheaamqypk qgifsvtcph
      481 pdiflvarie kvlqgsithc aepymkssds skvaqkvlkn akqacqrlgq yrmpfawaar
      541 tlfkdasgnl dknarfsaiy rqdsnklsnd dmlklladfr kpekmaklpv ilgnlditid
      601 nvssdfpnyv nssyiptkqf etcsktpitf eveefvpcip khtqpytiyt nhlyvypkyl
      661 kydsqksfak arniaicief kdsdeedsqp lkciygrpgg pvftrsafaa vlhhhqnpef
      721 ydeikielpt qlhekhhlll tffhvscdns skgstkkrdv vetqvgyswl pllkdgrvvt
      781 seqhipvsan lpsgylgyqe lgmgrhygpe ikwvdggkpl lkisthlvst vytqdqhlhn
      841 ffqycqktes gaqalgnelv kylkslhame ghvmiaflpt ilnqlfrvlt ratqeevavn
      901 vtrviihvva qcheeglesh lrsyvkyayk aepyvaseyk tvheeltksm ttilkpsadf
      961 ltsnkllkys wfffdvliks maqhliensk vkllrnqrfp asyhhavetv vnmlmphitq
     1021 kfrdnpeask nanhslavfi krcftfmdrg fvfkqinnyi scfapgdpkt lfeykfeflr
     1081 vvcnhehyip lnlpmpfgkg riqryqdlql dysltdefcr nhflvglllr evgtalqefr
     1141 evrliaisvl knllikhsfd dryasrshqa riatlylplf gllienvqri nvrdvspfpv
     1201 nagmtvkdes lalpavnplv tpqkgstldn slhkdllgai sgiaspytts tpninsvrna
     1261 dsrgslistd sgnslperns eksnsldkhq qsstlgnsvv rcdkldqsei ksllmcflyi
     1321 lksmsddalf tywnkastse lmdfftisev clhqfqymgk ryiasvrkis svlgisvdng
     1381 yghsdadvlh qslleaniat evcltaldtl slftlafknq lladhghnpl mkkvfdvylc
     1441 flqkhqseta lknvftalrs liykfpstfy egradmcaal cyeilkccns klssirteas
     1501 qllyflmrnn fdytgkksfv rthlqviisv sqliadvvgi ggtrfqqsls iinncansdr
     1561 likhtsfssd vkdltkrirt vlmataqmke hendpemlvd lqyslaksya stpelrktwl
     1621 dsmarihvkn gdlseaamcy vhvtalvaey ltrkeavqwe ppllphshsa clrrsrggvf
     1681 rqgctafrvi tpnideeasm medvgmqdvh fnedvlmell eqcadglwka eryeliadiy
     1741 kliipiyekr rdferlahly dtlhrayskv tevmhsgrrl lgtyfrvaff gqaaqyqftd
     1801 setdvegffe dedgkeyiyk epkltplsei sqrllklysd kfgsenvkmi qdsgkvnpkd
     1861 ldskyayiqv thvipffdek elqerktefe rshnirrfmf empftqtgkr qggveeqckr
     1921 rtiltaihcf pyvkkripvm yqhhtdlnpi evaidemskk vaelrqlcss aevdmiklql
     1981 klqgsvsvqv nagplayara flddtntkry pdnkvkllke vfrqfveacg qalavnerli
     2041 kedqleyqee mkanyremak elseimheqi cpleektsvl pnslhifnai sgtptstmvh
     2101 gmtssssvv
//
LOCUS       XP_006719985            2141 aa            linear   PRI 05-AUG-2025
DEFINITION  dedicator of cytokinesis protein 9 isoform X5 [Homo sapiens].
ACCESSION   XP_006719985
VERSION     XP_006719985.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006719922.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2141
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..2141
                     /product="dedicator of cytokinesis protein 9 isoform X5"
                     /calculated_mol_wt=244563
     Region          57..167
                     /region_name="DOCK_C-D_N"
                     /note="Dedicator of cytokinesis C/D, N terminal;
                     pfam11878"
                     /db_xref="CDD:463380"
     Region          181..304
                     /region_name="PH_DOCK-D"
                     /note="Dedicator of cytokinesis-D subfamily Pleckstrin
                     homology (PH) domain; cd13267"
                     /db_xref="CDD:270087"
     Region          650..839
                     /region_name="C2_Dock-D"
                     /note="C2 domains found in Dedicator Of CytoKinesis (Dock)
                     class C proteins; cd08697"
                     /db_xref="CDD:176079"
     Region          1646..2097
                     /region_name="DHR2_DOCK9"
                     /note="Dock Homology Region 2, a GEF domain, of Class D
                     Dedicator of Cytokinesis 9; cd11698"
                     /db_xref="CDD:212571"
     Site            order(1773,1783,1785..1786,1788..1789,1792..1793,
                     1795..1796,1799..1800)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            order(1807..1810,1812,1855..1856,1858..1861,1863..1864,
                     1883..1885,1902,1904,1933,1935,1942..1943,1949,1988..1989,
                     1992,2006,2008,2012,2015..2017,2020..2023,2025..2026,2029,
                     2057,2075..2076,2078..2079,2082)
                     /site_type="other"
                     /note="Cdc42 binding site [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            2020..2025
                     /site_type="other"
                     /note="nucleotide sensor"
                     /db_xref="CDD:212571"
     CDS             1..2141
                     /gene="DOCK9"
                     /gene_synonym="ZIZ1; ZIZIMIN1"
                     /coded_by="XM_006719922.2:178..6603"
                     /db_xref="GeneID:23348"
                     /db_xref="HGNC:HGNC:14132"
                     /db_xref="MIM:607325"
ORIGIN      
        1 mgcttsvilf kgirtvfern caymckqqge nnaleytayn wtkedselli sswlakpkli
       61 epldyenviv qkktqilndc lremllfpyd dfqtailrrq gryicstvpa kaeeeaqslf
      121 vteciktyns dwhlvnykye dysgefrqlp nkvvkldklp vhvyevdeev dkdedaaslg
      181 sqkggitkhg wlykgnmnsa isvtmrsfkr rffhliqlgd gsynlnfykd ekiskepkgs
      241 ifldscmgvv qnnkvrrfaf elkmqdkssy llaadsevem eewitilnki lqlnfeaamq
      301 ekrngdshed deqsklegsg sgldsylpel aksareaeik lksesrvklf yldpdaqkld
      361 fssaepevks feekfgkril vkcndlsfnl qccvaeneeg pttnvepffv tlslfdikyn
      421 rkisadfhvd lnhfsvrqml attspalmng sgqspsvlkg ilheaamqyp kqgifsvtcp
      481 hpdiflvari ekvlqgsith caepymkssd sskvaqkvlk nakqacqrlg qyrmpfawaa
      541 rtlfkdasgn ldknarfsai yrqdsnklsn ddmlklladf rkpekmaklp vilgnlditi
      601 dnvssdfpny vnssyiptkq fetcsktpit feveefvpci pkhtqpytiy tnhlyvypky
      661 lkydsqksfa karniaicie fkdsdeedsq plkciygrpg gpvftrsafa avlhhhqnpe
      721 fydeikielp tqlhekhhll ltffhvscdn sskgstkkrd vvetqvgysw lpllkdgrvv
      781 tseqhipvsa nlpsgylgyq elgmgrhygp eikwvdggkp llkisthlvs tvytqdqhlh
      841 nffqycqkte sgaqalgnel vkylkslham eghvmiaflp tilnqlfrvl tratqeevav
      901 nvtrviihvv aqcheegles hlrsyvkyay kaepyvasey ktvheeltks mttilkpsad
      961 fltsnkllky swfffdvlik smaqhliens kvkllrnqrf pasyhhavet vvnmlmphit
     1021 qkfrdnpeas knanhslavf ikrcftfmdr gfvfkqinny iscfapgdpk tlfeykfefl
     1081 rvvcnhehyi plnlpmpfgk griqryqdlq ldysltdefc rnhflvglll revgtalqef
     1141 revrliaisv lknllikhsf ddryasrshq ariatlylpl fgllienvqr invrdvspfp
     1201 vnagmtvkde slalpavnpl vtpqkgstld nslhkdllga isgiaspytt stpninsvrn
     1261 adsrgslist dsgnslpern seksnsldkh qqsstlgnsv vrcdkldqse iksllmcfly
     1321 ilksmsddal ftywnkasts elmdfftise vclhqfqymg kryiarnqeg lgpivhdrks
     1381 qtlpvsrnrt gmmharlqql gsldnsltfn hsyghsdadv lhqslleani atevcltald
     1441 tlslftlafk nqlladhghn plmkkvfdvy lcflqkhqse talknvftal rsliykfpst
     1501 fyegradmca alcyeilkcc nsklssirte asqllyflmr nnfdytgkks fvrthlqvii
     1561 svsqliadvv giggtrfqqs lsiinncans drlikhtsfs sdvkdltkri rtvlmataqm
     1621 kehendpeml vdlqyslaks yastpelrkt wldsmarihv kngdlseaam cyvhvtalva
     1681 eyltrkeavq weppllphsh saclrrsrgg vfrqgctafr vitpnideea smmedvgmqd
     1741 vhfnedvlme lleqcadglw kaeryeliad iykliipiye krrdferlah lydtlhrays
     1801 kvtevmhsgr rllgtyfrva ffgqaaqyqf tdsetdvegf fededgkeyi ykepkltpls
     1861 eisqrllkly sdkfgsenvk miqdsgkvnp kdldskyayi qvthvipffd ekelqerkte
     1921 fershnirrf mfempftqtg krqggveeqc krrtiltaih cfpyvkkrip vmyqhhtdln
     1981 pievaidems kkvaelrqlc ssaevdmikl qlklqgsvsv qvnagplaya raflddtntk
     2041 rypdnkvkll kevfrqfvea cgqalavner likedqleyq eemkanyrem akelseimhe
     2101 qicpleekts vlpnslhifn aisgtptstm vhgmtssssv v
//
LOCUS       XP_016875996            2103 aa            linear   PRI 05-AUG-2025
DEFINITION  dedicator of cytokinesis protein 9 isoform X6 [Homo sapiens].
ACCESSION   XP_016875996
VERSION     XP_016875996.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020507.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2103
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..2103
                     /product="dedicator of cytokinesis protein 9 isoform X6"
                     /calculated_mol_wt=240370
     Region          56..166
                     /region_name="DOCK_C-D_N"
                     /note="Dedicator of cytokinesis C/D, N terminal;
                     pfam11878"
                     /db_xref="CDD:463380"
     Region          180..303
                     /region_name="PH_DOCK-D"
                     /note="Dedicator of cytokinesis-D subfamily Pleckstrin
                     homology (PH) domain; cd13267"
                     /db_xref="CDD:270087"
     Region          649..838
                     /region_name="C2_Dock-D"
                     /note="C2 domains found in Dedicator Of CytoKinesis (Dock)
                     class C proteins; cd08697"
                     /db_xref="CDD:176079"
     Region          1645..2059
                     /region_name="DHR2_DOCK9"
                     /note="Dock Homology Region 2, a GEF domain, of Class D
                     Dedicator of Cytokinesis 9; cd11698"
                     /db_xref="CDD:212571"
     Site            order(1749,1759,1761..1762,1764..1765,1768..1769,
                     1771..1772,1775..1776)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            order(1783..1786,1788,1817..1818,1820..1823,1825..1826,
                     1845..1847,1864,1866,1895,1897,1904..1905,1911,1950..1951,
                     1954,1968,1970,1974,1977..1979,1982..1985,1987..1988,1991,
                     2019,2037..2038,2040..2041,2044)
                     /site_type="other"
                     /note="Cdc42 binding site [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            1982..1987
                     /site_type="other"
                     /note="nucleotide sensor"
                     /db_xref="CDD:212571"
     CDS             1..2103
                     /gene="DOCK9"
                     /gene_synonym="ZIZ1; ZIZIMIN1"
                     /coded_by="XM_017020507.2:16..6327"
                     /db_xref="GeneID:23348"
                     /db_xref="HGNC:HGNC:14132"
                     /db_xref="MIM:607325"
ORIGIN      
        1 mgtyllvalp cfnhqpgiwf ltitqmkafq nwknfrtsrq pccllsstsf rfkakpklie
       61 pldyenvivq kktqilndcl remllfpydd fqtailrrqg ryicstvpak aeeeaqslfv
      121 teciktynsd whlvnykyed ysgefrqlpn kvvkldklpv hvyevdeevd kdedaaslgs
      181 qkggitkhgw lykgnmnsai svtmrsfkrr ffhliqlgdg synlnfykde kiskepkgsi
      241 fldscmgvvq nnkvrrfafe lkmqdkssyl laadseveme ewitilnkil qlnfeaamqe
      301 krngdshedd eqsklegsgs gldsylpela ksareaeikl ksesrvklfy ldpdaqkldf
      361 ssaepevksf eekfgkrilv kcndlsfnlq ccvaeneegp ttnvepffvt lslfdikynr
      421 kisadfhvdl nhfsvrqmla ttspalmngs gqspsvlkgi lheaamqypk qgifsvtcph
      481 pdiflvarie kvlqgsithc aepymkssds skvaqkvlkn akqacqrlgq yrmpfawaar
      541 tlfkdasgnl dknarfsaiy rqdsnklsnd dmlklladfr kpekmaklpv ilgnlditid
      601 nvssdfpnyv nssyiptkqf etcsktpitf eveefvpcip khtqpytiyt nhlyvypkyl
      661 kydsqksfak arniaicief kdsdeedsqp lkciygrpgg pvftrsafaa vlhhhqnpef
      721 ydeikielpt qlhekhhlll tffhvscdns skgstkkrdv vetqvgyswl pllkdgrvvt
      781 seqhipvsan lpsgylgyqe lgmgrhygpe ikwvdggkpl lkisthlvst vytqdqhlhn
      841 ffqycqktes gaqalgnelv kylkslhame ghvmiaflpt ilnqlfrvlt ratqeevavn
      901 vtrviihvva qcheeglesh lrsyvkyayk aepyvaseyk tvheeltksm ttilkpsadf
      961 ltsnkllkys wfffdvliks maqhliensk vkllrnqrfp asyhhavetv vnmlmphitq
     1021 kfrdnpeask nanhslavfi krcftfmdrg fvfkqinnyi scfapgdpkt lfeykfeflr
     1081 vvcnhehyip lnlpmpfgkg riqryqdlql dysltdefcr nhflvglllr evgtalqefr
     1141 evrliaisvl knllikhsfd dryasrshqa riatlylplf gllienvqri nvrdvspfpv
     1201 nagmtvkdes lalpavnplv tpqkgstldn slhkdllgai sgiaspytts tpninsvrna
     1261 dsrgslistd sgnslperns eksnsldkhq qsstlgnsvv rcdkldqsei ksllmcflyi
     1321 lksmsddalf tywnkastse lmdfftisev clhqfqymgk ryiarnqegl gpivhdrksq
     1381 tlpvsrnrtg mmharlqqlg sldnsltfnh syghsdadvl hqslleania tevcltaldt
     1441 lslftlafkn qlladhghnp lmkkvfdvyl cflqkhqset alknvftalr sliykfpstf
     1501 yegradmcaa lcyeilkccn sklssirtea sqllyflmrn nfdytgkksf vrthlqviis
     1561 vsqliadvvg iggtrfqqsl siinncansd rlikhtsfss dvkdltkrir tvlmataqmk
     1621 ehendpemlv dlqyslaksy astpelrktw ldsmarihvk ngdlseaamc yvhvtalvae
     1681 yltrkgvfrq gctafrvitp nideeasmme dvgmqdvhfn edvlmelleq cadglwkaer
     1741 yeliadiykl iipiyekrrd ferlahlydt lhrayskvte vmhsgrrllg tyfrvaffgq
     1801 gffededgke yiykepkltp lseisqrllk lysdkfgsen vkmiqdsgkv npkdldskya
     1861 yiqvthvipf fdekelqerk tefershnir rfmfempftq tgkrqggvee qckrrtilta
     1921 ihcfpyvkkr ipvmyqhhtd lnpievaide mskkvaelrq lcssaevdmi klqlklqgsv
     1981 svqvnagpla yaraflddtn tkrypdnkvk llkevfrqfv eacgqalavn erlikedqle
     2041 yqeemkanyr emakelseim heqicpleek tsvlpnslhi fnaisgtpts tmvhgmtsss
     2101 svv
//
LOCUS       XP_047286186            2103 aa            linear   PRI 05-AUG-2025
DEFINITION  dedicator of cytokinesis protein 9 isoform X7 [Homo sapiens].
ACCESSION   XP_047286186
VERSION     XP_047286186.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430230.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2103
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..2103
                     /product="dedicator of cytokinesis protein 9 isoform X7"
                     /calculated_mol_wt=240395
     Region          56..166
                     /region_name="DOCK_C-D_N"
                     /note="Dedicator of cytokinesis C/D, N terminal;
                     pfam11878"
                     /db_xref="CDD:463380"
     Region          180..303
                     /region_name="PH_DOCK-D"
                     /note="Dedicator of cytokinesis-D subfamily Pleckstrin
                     homology (PH) domain; cd13267"
                     /db_xref="CDD:270087"
     Region          649..838
                     /region_name="C2_Dock-D"
                     /note="C2 domains found in Dedicator Of CytoKinesis (Dock)
                     class C proteins; cd08697"
                     /db_xref="CDD:176079"
     Region          1622..2059
                     /region_name="DHR2_DOCK9"
                     /note="Dock Homology Region 2, a GEF domain, of Class D
                     Dedicator of Cytokinesis 9; cd11698"
                     /db_xref="CDD:212571"
     Site            order(1749,1759,1761..1762,1764..1765,1768..1769,
                     1771..1772,1775..1776)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            order(1783..1786,1788,1817..1818,1820..1823,1825..1826,
                     1845..1847,1864,1866,1895,1897,1904..1905,1911,1950..1951,
                     1954,1968,1970,1974,1977..1979,1982..1985,1987..1988,1991,
                     2019,2037..2038,2040..2041,2044)
                     /site_type="other"
                     /note="Cdc42 binding site [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            1982..1987
                     /site_type="other"
                     /note="nucleotide sensor"
                     /db_xref="CDD:212571"
     CDS             1..2103
                     /gene="DOCK9"
                     /gene_synonym="ZIZ1; ZIZIMIN1"
                     /coded_by="XM_047430230.1:16..6327"
                     /db_xref="GeneID:23348"
                     /db_xref="HGNC:HGNC:14132"
                     /db_xref="MIM:607325"
ORIGIN      
        1 mgtyllvalp cfnhqpgiwf ltitqmkafq nwknfrtsrq pccllsstsf rfkakpklie
       61 pldyenvivq kktqilndcl remllfpydd fqtailrrqg ryicstvpak aeeeaqslfv
      121 teciktynsd whlvnykyed ysgefrqlpn kvvkldklpv hvyevdeevd kdedaaslgs
      181 qkggitkhgw lykgnmnsai svtmrsfkrr ffhliqlgdg synlnfykde kiskepkgsi
      241 fldscmgvvq nnkvrrfafe lkmqdkssyl laadseveme ewitilnkil qlnfeaamqe
      301 krngdshedd eqsklegsgs gldsylpela ksareaeikl ksesrvklfy ldpdaqkldf
      361 ssaepevksf eekfgkrilv kcndlsfnlq ccvaeneegp ttnvepffvt lslfdikynr
      421 kisadfhvdl nhfsvrqmla ttspalmngs gqspsvlkgi lheaamqypk qgifsvtcph
      481 pdiflvarie kvlqgsithc aepymkssds skvaqkvlkn akqacqrlgq yrmpfawaar
      541 tlfkdasgnl dknarfsaiy rqdsnklsnd dmlklladfr kpekmaklpv ilgnlditid
      601 nvssdfpnyv nssyiptkqf etcsktpitf eveefvpcip khtqpytiyt nhlyvypkyl
      661 kydsqksfak arniaicief kdsdeedsqp lkciygrpgg pvftrsafaa vlhhhqnpef
      721 ydeikielpt qlhekhhlll tffhvscdns skgstkkrdv vetqvgyswl pllkdgrvvt
      781 seqhipvsan lpsgylgyqe lgmgrhygpe ikwvdggkpl lkisthlvst vytqdqhlhn
      841 ffqycqktes gaqalgnelv kylkslhame ghvmiaflpt ilnqlfrvlt ratqeevavn
      901 vtrviihvva qcheeglesh lrsyvkyayk aepyvaseyk tvheeltksm ttilkpsadf
      961 ltsnkllkys wfffdvliks maqhliensk vkllrnqrfp asyhhavetv vnmlmphitq
     1021 kfrdnpeask nanhslavfi krcftfmdrg fvfkqinnyi scfapgdpkt lfeykfeflr
     1081 vvcnhehyip lnlpmpfgkg riqryqdlql dysltdefcr nhflvglllr evgtalqefr
     1141 evrliaisvl knllikhsfd dryasrshqa riatlylplf gllienvqri nvrdvspfpv
     1201 nagmtvkdes lalpavnplv tpqkgstldn slhkdllgai sgiaspytts tpninsvrna
     1261 dsrgslistd sgnslperns eksnsldkhq qsstlgnsvv rcdkldqsei ksllmcflyi
     1321 lksmsddalf tywnkastse lmdfftisev clhqfqymgk ryiartgmmh arlqqlgsld
     1381 nsltfnhsyg hsdadvlhqs lleaniatev cltaldtlsl ftlafknqll adhghnplmk
     1441 kvfdvylcfl qkhqsetalk nvftalrsli ykfpstfyeg radmcaalcy eilkccnskl
     1501 ssirteasql lyflmrnnfd ytgkksfvrt hlqviisvsq liadvvgigg trfqqslsii
     1561 nncansdrli khtsfssdvk dltkrirtvl mataqmkehe ndpemlvdlq yslaksyast
     1621 pelrktwlds marihvkngd lseaamcyvh vtalvaeylt rkeavqwepp llphshsacl
     1681 rrsrggvfrq gctafrvitp nideeasmme dvgmqdvhfn edvlmelleq cadglwkaer
     1741 yeliadiykl iipiyekrrd ferlahlydt lhrayskvte vmhsgrrllg tyfrvaffgq
     1801 gffededgke yiykepkltp lseisqrllk lysdkfgsen vkmiqdsgkv npkdldskya
     1861 yiqvthvipf fdekelqerk tefershnir rfmfempftq tgkrqggvee qckrrtilta
     1921 ihcfpyvkkr ipvmyqhhtd lnpievaide mskkvaelrq lcssaevdmi klqlklqgsv
     1981 svqvnagpla yaraflddtn tkrypdnkvk llkevfrqfv eacgqalavn erlikedqle
     2041 yqeemkanyr emakelseim heqicpleek tsvlpnslhi fnaisgtpts tmvhgmtsss
     2101 svv
//
LOCUS       XP_016875997            2095 aa            linear   PRI 05-AUG-2025
DEFINITION  dedicator of cytokinesis protein 9 isoform X8 [Homo sapiens].
ACCESSION   XP_016875997
VERSION     XP_016875997.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020508.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2095
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..2095
                     /product="dedicator of cytokinesis protein 9 isoform X8"
                     /calculated_mol_wt=239311
     Region          56..166
                     /region_name="DOCK_C-D_N"
                     /note="Dedicator of cytokinesis C/D, N terminal;
                     pfam11878"
                     /db_xref="CDD:463380"
     Region          180..303
                     /region_name="PH_DOCK-D"
                     /note="Dedicator of cytokinesis-D subfamily Pleckstrin
                     homology (PH) domain; cd13267"
                     /db_xref="CDD:270087"
     Region          649..838
                     /region_name="C2_Dock-D"
                     /note="C2 domains found in Dedicator Of CytoKinesis (Dock)
                     class C proteins; cd08697"
                     /db_xref="CDD:176079"
     Region          1614..2051
                     /region_name="DHR2_DOCK9"
                     /note="Dock Homology Region 2, a GEF domain, of Class D
                     Dedicator of Cytokinesis 9; cd11698"
                     /db_xref="CDD:212571"
     Site            order(1741,1751,1753..1754,1756..1757,1760..1761,
                     1763..1764,1767..1768)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            order(1775..1778,1780,1809..1810,1812..1815,1817..1818,
                     1837..1839,1856,1858,1887,1889,1896..1897,1903,1942..1943,
                     1946,1960,1962,1966,1969..1971,1974..1977,1979..1980,1983,
                     2011,2029..2030,2032..2033,2036)
                     /site_type="other"
                     /note="Cdc42 binding site [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            1974..1979
                     /site_type="other"
                     /note="nucleotide sensor"
                     /db_xref="CDD:212571"
     CDS             1..2095
                     /gene="DOCK9"
                     /gene_synonym="ZIZ1; ZIZIMIN1"
                     /coded_by="XM_017020508.2:16..6303"
                     /db_xref="GeneID:23348"
                     /db_xref="HGNC:HGNC:14132"
                     /db_xref="MIM:607325"
ORIGIN      
        1 mgtyllvalp cfnhqpgiwf ltitqmkafq nwknfrtsrq pccllsstsf rfkakpklie
       61 pldyenvivq kktqilndcl remllfpydd fqtailrrqg ryicstvpak aeeeaqslfv
      121 teciktynsd whlvnykyed ysgefrqlpn kvvkldklpv hvyevdeevd kdedaaslgs
      181 qkggitkhgw lykgnmnsai svtmrsfkrr ffhliqlgdg synlnfykde kiskepkgsi
      241 fldscmgvvq nnkvrrfafe lkmqdkssyl laadseveme ewitilnkil qlnfeaamqe
      301 krngdshedd eqsklegsgs gldsylpela ksareaeikl ksesrvklfy ldpdaqkldf
      361 ssaepevksf eekfgkrilv kcndlsfnlq ccvaeneegp ttnvepffvt lslfdikynr
      421 kisadfhvdl nhfsvrqmla ttspalmngs gqspsvlkgi lheaamqypk qgifsvtcph
      481 pdiflvarie kvlqgsithc aepymkssds skvaqkvlkn akqacqrlgq yrmpfawaar
      541 tlfkdasgnl dknarfsaiy rqdsnklsnd dmlklladfr kpekmaklpv ilgnlditid
      601 nvssdfpnyv nssyiptkqf etcsktpitf eveefvpcip khtqpytiyt nhlyvypkyl
      661 kydsqksfak arniaicief kdsdeedsqp lkciygrpgg pvftrsafaa vlhhhqnpef
      721 ydeikielpt qlhekhhlll tffhvscdns skgstkkrdv vetqvgyswl pllkdgrvvt
      781 seqhipvsan lpsgylgyqe lgmgrhygpe ikwvdggkpl lkisthlvst vytqdqhlhn
      841 ffqycqktes gaqalgnelv kylkslhame ghvmiaflpt ilnqlfrvlt ratqeevavn
      901 vtrviihvva qcheeglesh lrsyvkyayk aepyvaseyk tvheeltksm ttilkpsadf
      961 ltsnkllkys wfffdvliks maqhliensk vkllrnqrfp asyhhavetv vnmlmphitq
     1021 kfrdnpeask nanhslavfi krcftfmdrg fvfkqinnyi scfapgdpkt lfeykfeflr
     1081 vvcnhehyip lnlpmpfgkg riqryqdlql dysltdefcr nhflvglllr evgtalqefr
     1141 evrliaisvl knllikhsfd dryasrshqa riatlylplf gllienvqri nvrdvspfpv
     1201 nagmtvkdes lalpavnplv tpqkgstldn slhkdllgai sgiaspytts tpninsvrna
     1261 dsrgslistd sgnslperns eksnsldkhq qsstlgnsvv rcdkldqsei ksllmcflyi
     1321 lksmsddalf tywnkastse lmdfftisev clhqfqymgk ryiasvrkis svlgisvdng
     1381 yghsdadvlh qslleaniat evcltaldtl slftlafknq lladhghnpl mkkvfdvylc
     1441 flqkhqseta lknvftalrs liykfpstfy egradmcaal cyeilkccns klssirteas
     1501 qllyflmrnn fdytgkksfv rthlqviisv sqliadvvgi ggtrfqqsls iinncansdr
     1561 likhtsfssd vkdltkrirt vlmataqmke hendpemlvd lqyslaksya stpelrktwl
     1621 dsmarihvkn gdlseaamcy vhvtalvaey ltrkeavqwe ppllphshsa clrrsrggvf
     1681 rqgctafrvi tpnideeasm medvgmqdvh fnedvlmell eqcadglwka eryeliadiy
     1741 kliipiyekr rdferlahly dtlhrayskv tevmhsgrrl lgtyfrvaff gqgffededg
     1801 keyiykepkl tplseisqrl lklysdkfgs envkmiqdsg kvnpkdldsk yayiqvthvi
     1861 pffdekelqe rktefershn irrfmfempf tqtgkrqggv eeqckrrtil taihcfpyvk
     1921 kripvmyqhh tdlnpievai demskkvael rqlcssaevd miklqlklqg svsvqvnagp
     1981 layarafldd tntkrypdnk vkllkevfrq fveacgqala vnerlikedq leyqeemkan
     2041 yremakelse imheqicple ektsvlpnsl hifnaisgtp tstmvhgmts sssvv
//
LOCUS       XP_006719987            2130 aa            linear   PRI 05-AUG-2025
DEFINITION  dedicator of cytokinesis protein 9 isoform X9 [Homo sapiens].
ACCESSION   XP_006719987
VERSION     XP_006719987.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006719924.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2130
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..2130
                     /product="dedicator of cytokinesis protein 9 isoform X9"
                     /calculated_mol_wt=242885
     Region          46..156
                     /region_name="DOCK_C-D_N"
                     /note="Dedicator of cytokinesis C/D, N terminal;
                     pfam11878"
                     /db_xref="CDD:463380"
     Region          170..293
                     /region_name="PH_DOCK-D"
                     /note="Dedicator of cytokinesis-D subfamily Pleckstrin
                     homology (PH) domain; cd13267"
                     /db_xref="CDD:270087"
     Region          639..828
                     /region_name="C2_Dock-D"
                     /note="C2 domains found in Dedicator Of CytoKinesis (Dock)
                     class C proteins; cd08697"
                     /db_xref="CDD:176079"
     Region          1635..2086
                     /region_name="DHR2_DOCK9"
                     /note="Dock Homology Region 2, a GEF domain, of Class D
                     Dedicator of Cytokinesis 9; cd11698"
                     /db_xref="CDD:212571"
     Site            order(1762,1772,1774..1775,1777..1778,1781..1782,
                     1784..1785,1788..1789)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            order(1796..1799,1801,1844..1845,1847..1850,1852..1853,
                     1872..1874,1891,1893,1922,1924,1931..1932,1938,1977..1978,
                     1981,1995,1997,2001,2004..2006,2009..2012,2014..2015,2018,
                     2046,2064..2065,2067..2068,2071)
                     /site_type="other"
                     /note="Cdc42 binding site [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            2009..2014
                     /site_type="other"
                     /note="nucleotide sensor"
                     /db_xref="CDD:212571"
     CDS             1..2130
                     /gene="DOCK9"
                     /gene_synonym="ZIZ1; ZIZIMIN1"
                     /coded_by="XM_006719924.3:344..6736"
                     /db_xref="GeneID:23348"
                     /db_xref="HGNC:HGNC:14132"
                     /db_xref="MIM:607325"
ORIGIN      
        1 msqppllpas aetrkftral skpgtaaelr qsvsevvrgs vllakpklie pldyenvivq
       61 kktqilndcl remllfpydd fqtailrrqg ryicstvpak aeeeaqslfv teciktynsd
      121 whlvnykyed ysgefrqlpn kvvkldklpv hvyevdeevd kdedaaslgs qkggitkhgw
      181 lykgnmnsai svtmrsfkrr ffhliqlgdg synlnfykde kiskepkgsi fldscmgvvq
      241 nnkvrrfafe lkmqdkssyl laadseveme ewitilnkil qlnfeaamqe krngdshedd
      301 eqsklegsgs gldsylpela ksareaeikl ksesrvklfy ldpdaqkldf ssaepevksf
      361 eekfgkrilv kcndlsfnlq ccvaeneegp ttnvepffvt lslfdikynr kisadfhvdl
      421 nhfsvrqmla ttspalmngs gqspsvlkgi lheaamqypk qgifsvtcph pdiflvarie
      481 kvlqgsithc aepymkssds skvaqkvlkn akqacqrlgq yrmpfawaar tlfkdasgnl
      541 dknarfsaiy rqdsnklsnd dmlklladfr kpekmaklpv ilgnlditid nvssdfpnyv
      601 nssyiptkqf etcsktpitf eveefvpcip khtqpytiyt nhlyvypkyl kydsqksfak
      661 arniaicief kdsdeedsqp lkciygrpgg pvftrsafaa vlhhhqnpef ydeikielpt
      721 qlhekhhlll tffhvscdns skgstkkrdv vetqvgyswl pllkdgrvvt seqhipvsan
      781 lpsgylgyqe lgmgrhygpe ikwvdggkpl lkisthlvst vytqdqhlhn ffqycqktes
      841 gaqalgnelv kylkslhame ghvmiaflpt ilnqlfrvlt ratqeevavn vtrviihvva
      901 qcheeglesh lrsyvkyayk aepyvaseyk tvheeltksm ttilkpsadf ltsnkllkys
      961 wfffdvliks maqhliensk vkllrnqrfp asyhhavetv vnmlmphitq kfrdnpeask
     1021 nanhslavfi krcftfmdrg fvfkqinnyi scfapgdpkt lfeykfeflr vvcnhehyip
     1081 lnlpmpfgkg riqryqdlql dysltdefcr nhflvglllr evgtalqefr evrliaisvl
     1141 knllikhsfd dryasrshqa riatlylplf gllienvqri nvrdvspfpv nagmtvkdes
     1201 lalpavnplv tpqkgstldn slhkdllgai sgiaspytts tpninsvrna dsrgslistd
     1261 sgnslperns eksnsldkhq qsstlgnsvv rcdkldqsei ksllmcflyi lksmsddalf
     1321 tywnkastse lmdfftisev clhqfqymgk ryiarnqegl gpivhdrksq tlpvsrnrtg
     1381 mmharlqqlg sldnsltfnh syghsdadvl hqslleania tevcltaldt lslftlafkn
     1441 qlladhghnp lmkkvfdvyl cflqkhqset alknvftalr sliykfpstf yegradmcaa
     1501 lcyeilkccn sklssirtea sqllyflmrn nfdytgkksf vrthlqviis vsqliadvvg
     1561 iggtrfqqsl siinncansd rlikhtsfss dvkdltkrir tvlmataqmk ehendpemlv
     1621 dlqyslaksy astpelrktw ldsmarihvk ngdlseaamc yvhvtalvae yltrkeavqw
     1681 eppllphshs aclrrsrggv frqgctafrv itpnideeas mmedvgmqdv hfnedvlmel
     1741 leqcadglwk aeryeliadi ykliipiyek rrdferlahl ydtlhraysk vtevmhsgrr
     1801 llgtyfrvaf fgqaaqyqft dsetdvegff ededgkeyiy kepkltplse isqrllklys
     1861 dkfgsenvkm iqdsgkvnpk dldskyayiq vthvipffde kelqerktef ershnirrfm
     1921 fempftqtgk rqggveeqck rrtiltaihc fpyvkkripv myqhhtdlnp ievaidemsk
     1981 kvaelrqlcs saevdmiklq lklqgsvsvq vnagplayar aflddtntkr ypdnkvkllk
     2041 evfrqfveac gqalavnerl ikedqleyqe emkanyrema kelseimheq icpleektsv
     2101 lpnslhifna isgtptstmv hgmtssssvv
//
LOCUS       XP_006719988            2129 aa            linear   PRI 05-AUG-2025
DEFINITION  dedicator of cytokinesis protein 9 isoform X10 [Homo sapiens].
ACCESSION   XP_006719988
VERSION     XP_006719988.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006719925.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2129
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..2129
                     /product="dedicator of cytokinesis protein 9 isoform X10"
                     /calculated_mol_wt=242865
     Region          45..155
                     /region_name="DOCK_C-D_N"
                     /note="Dedicator of cytokinesis C/D, N terminal;
                     pfam11878"
                     /db_xref="CDD:463380"
     Region          169..292
                     /region_name="PH_DOCK-D"
                     /note="Dedicator of cytokinesis-D subfamily Pleckstrin
                     homology (PH) domain; cd13267"
                     /db_xref="CDD:270087"
     Region          638..827
                     /region_name="C2_Dock-D"
                     /note="C2 domains found in Dedicator Of CytoKinesis (Dock)
                     class C proteins; cd08697"
                     /db_xref="CDD:176079"
     Region          1634..2085
                     /region_name="DHR2_DOCK9"
                     /note="Dock Homology Region 2, a GEF domain, of Class D
                     Dedicator of Cytokinesis 9; cd11698"
                     /db_xref="CDD:212571"
     Site            order(1761,1771,1773..1774,1776..1777,1780..1781,
                     1783..1784,1787..1788)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            order(1795..1798,1800,1843..1844,1846..1849,1851..1852,
                     1871..1873,1890,1892,1921,1923,1930..1931,1937,1976..1977,
                     1980,1994,1996,2000,2003..2005,2008..2011,2013..2014,2017,
                     2045,2063..2064,2066..2067,2070)
                     /site_type="other"
                     /note="Cdc42 binding site [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            2008..2013
                     /site_type="other"
                     /note="nucleotide sensor"
                     /db_xref="CDD:212571"
     CDS             1..2129
                     /gene="DOCK9"
                     /gene_synonym="ZIZ1; ZIZIMIN1"
                     /coded_by="XM_006719925.2:156..6545"
                     /db_xref="GeneID:23348"
                     /db_xref="HGNC:HGNC:14132"
                     /db_xref="MIM:607325"
ORIGIN      
        1 mqadkcrtss rsvkkelvie splqykdaaq geveaespgp vpakpkliep ldyenvivqk
       61 ktqilndclr emllfpyddf qtailrrqgr yicstvpaka eeeaqslfvt eciktynsdw
      121 hlvnykyedy sgefrqlpnk vvkldklpvh vyevdeevdk dedaaslgsq kggitkhgwl
      181 ykgnmnsais vtmrsfkrrf fhliqlgdgs ynlnfykdek iskepkgsif ldscmgvvqn
      241 nkvrrfafel kmqdkssyll aadsevemee witilnkilq lnfeaamqek rngdshedde
      301 qsklegsgsg ldsylpelak sareaeiklk sesrvklfyl dpdaqkldfs saepevksfe
      361 ekfgkrilvk cndlsfnlqc cvaeneegpt tnvepffvtl slfdikynrk isadfhvdln
      421 hfsvrqmlat tspalmngsg qspsvlkgil heaamqypkq gifsvtcphp diflvariek
      481 vlqgsithca epymkssdss kvaqkvlkna kqacqrlgqy rmpfawaart lfkdasgnld
      541 knarfsaiyr qdsnklsndd mlklladfrk pekmaklpvi lgnlditidn vssdfpnyvn
      601 ssyiptkqfe tcsktpitfe veefvpcipk htqpytiytn hlyvypkylk ydsqksfaka
      661 rniaiciefk dsdeedsqpl kciygrpggp vftrsafaav lhhhqnpefy deikielptq
      721 lhekhhlllt ffhvscdnss kgstkkrdvv etqvgyswlp llkdgrvvts eqhipvsanl
      781 psgylgyqel gmgrhygpei kwvdggkpll kisthlvstv ytqdqhlhnf fqycqktesg
      841 aqalgnelvk ylkslhameg hvmiaflpti lnqlfrvltr atqeevavnv trviihvvaq
      901 cheegleshl rsyvkyayka epyvaseykt vheeltksmt tilkpsadfl tsnkllkysw
      961 fffdvliksm aqhlienskv kllrnqrfpa syhhavetvv nmlmphitqk frdnpeaskn
     1021 anhslavfik rcftfmdrgf vfkqinnyis cfapgdpktl feykfeflrv vcnhehyipl
     1081 nlpmpfgkgr iqryqdlqld ysltdefcrn hflvglllre vgtalqefre vrliaisvlk
     1141 nllikhsfdd ryasrshqar iatlylplfg llienvqrin vrdvspfpvn agmtvkdesl
     1201 alpavnplvt pqkgstldns lhkdllgais giaspyttst pninsvrnad srgslistds
     1261 gnslpernse ksnsldkhqq sstlgnsvvr cdkldqseik sllmcflyil ksmsddalft
     1321 ywnkastsel mdfftisevc lhqfqymgkr yiarnqeglg pivhdrksqt lpvsrnrtgm
     1381 mharlqqlgs ldnsltfnhs yghsdadvlh qslleaniat evcltaldtl slftlafknq
     1441 lladhghnpl mkkvfdvylc flqkhqseta lknvftalrs liykfpstfy egradmcaal
     1501 cyeilkccns klssirteas qllyflmrnn fdytgkksfv rthlqviisv sqliadvvgi
     1561 ggtrfqqsls iinncansdr likhtsfssd vkdltkrirt vlmataqmke hendpemlvd
     1621 lqyslaksya stpelrktwl dsmarihvkn gdlseaamcy vhvtalvaey ltrkeavqwe
     1681 ppllphshsa clrrsrggvf rqgctafrvi tpnideeasm medvgmqdvh fnedvlmell
     1741 eqcadglwka eryeliadiy kliipiyekr rdferlahly dtlhrayskv tevmhsgrrl
     1801 lgtyfrvaff gqaaqyqftd setdvegffe dedgkeyiyk epkltplsei sqrllklysd
     1861 kfgsenvkmi qdsgkvnpkd ldskyayiqv thvipffdek elqerktefe rshnirrfmf
     1921 empftqtgkr qggveeqckr rtiltaihcf pyvkkripvm yqhhtdlnpi evaidemskk
     1981 vaelrqlcss aevdmiklql klqgsvsvqv nagplayara flddtntkry pdnkvkllke
     2041 vfrqfveacg qalavnerli kedqleyqee mkanyremak elseimheqi cpleektsvl
     2101 pnslhifnai sgtptstmvh gmtssssvv
//
LOCUS       XP_016875999            2086 aa            linear   PRI 05-AUG-2025
DEFINITION  dedicator of cytokinesis protein 9 isoform X11 [Homo sapiens].
ACCESSION   XP_016875999
VERSION     XP_016875999.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020510.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2086
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..2086
                     /product="dedicator of cytokinesis protein 9 isoform X11"
                     /calculated_mol_wt=238287
     Region          56..166
                     /region_name="DOCK_C-D_N"
                     /note="Dedicator of cytokinesis C/D, N terminal;
                     pfam11878"
                     /db_xref="CDD:463380"
     Region          180..303
                     /region_name="PH_DOCK-D"
                     /note="Dedicator of cytokinesis-D subfamily Pleckstrin
                     homology (PH) domain; cd13267"
                     /db_xref="CDD:270087"
     Region          649..838
                     /region_name="C2_Dock-D"
                     /note="C2 domains found in Dedicator Of CytoKinesis (Dock)
                     class C proteins; cd08697"
                     /db_xref="CDD:176079"
     Region          1614..2042
                     /region_name="DHR2_DOCK9"
                     /note="Dock Homology Region 2, a GEF domain, of Class D
                     Dedicator of Cytokinesis 9; cd11698"
                     /db_xref="CDD:212571"
     Site            order(1718,1728,1730..1731,1733..1734,1737..1738,
                     1740..1741,1744..1745)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            order(1752..1755,1757,1800..1801,1803..1806,1808..1809,
                     1828..1830,1847,1849,1878,1880,1887..1888,1894,1933..1934,
                     1937,1951,1953,1957,1960..1962,1965..1968,1970..1971,1974,
                     2002,2020..2021,2023..2024,2027)
                     /site_type="other"
                     /note="Cdc42 binding site [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            1965..1970
                     /site_type="other"
                     /note="nucleotide sensor"
                     /db_xref="CDD:212571"
     CDS             1..2086
                     /gene="DOCK9"
                     /gene_synonym="ZIZ1; ZIZIMIN1"
                     /coded_by="XM_017020510.2:16..6276"
                     /db_xref="GeneID:23348"
                     /db_xref="HGNC:HGNC:14132"
                     /db_xref="MIM:607325"
ORIGIN      
        1 mgtyllvalp cfnhqpgiwf ltitqmkafq nwknfrtsrq pccllsstsf rfkakpklie
       61 pldyenvivq kktqilndcl remllfpydd fqtailrrqg ryicstvpak aeeeaqslfv
      121 teciktynsd whlvnykyed ysgefrqlpn kvvkldklpv hvyevdeevd kdedaaslgs
      181 qkggitkhgw lykgnmnsai svtmrsfkrr ffhliqlgdg synlnfykde kiskepkgsi
      241 fldscmgvvq nnkvrrfafe lkmqdkssyl laadseveme ewitilnkil qlnfeaamqe
      301 krngdshedd eqsklegsgs gldsylpela ksareaeikl ksesrvklfy ldpdaqkldf
      361 ssaepevksf eekfgkrilv kcndlsfnlq ccvaeneegp ttnvepffvt lslfdikynr
      421 kisadfhvdl nhfsvrqmla ttspalmngs gqspsvlkgi lheaamqypk qgifsvtcph
      481 pdiflvarie kvlqgsithc aepymkssds skvaqkvlkn akqacqrlgq yrmpfawaar
      541 tlfkdasgnl dknarfsaiy rqdsnklsnd dmlklladfr kpekmaklpv ilgnlditid
      601 nvssdfpnyv nssyiptkqf etcsktpitf eveefvpcip khtqpytiyt nhlyvypkyl
      661 kydsqksfak arniaicief kdsdeedsqp lkciygrpgg pvftrsafaa vlhhhqnpef
      721 ydeikielpt qlhekhhlll tffhvscdns skgstkkrdv vetqvgyswl pllkdgrvvt
      781 seqhipvsan lpsgylgyqe lgmgrhygpe ikwvdggkpl lkisthlvst vytqdqhlhn
      841 ffqycqktes gaqalgnelv kylkslhame ghvmiaflpt ilnqlfrvlt ratqeevavn
      901 vtrviihvva qcheeglesh lrsyvkyayk aepyvaseyk tvheeltksm ttilkpsadf
      961 ltsnkllkys wfffdvliks maqhliensk vkllrnqrfp asyhhavetv vnmlmphitq
     1021 kfrdnpeask nanhslavfi krcftfmdrg fvfkqinnyi scfapgdpkt lfeykfeflr
     1081 vvcnhehyip lnlpmpfgkg riqryqdlql dysltdefcr nhflvglllr evgtalqefr
     1141 evrliaisvl knllikhsfd dryasrshqa riatlylplf gllienvqri nvrdvspfpv
     1201 nagmtvkdes lalpavnplv tpqkgstldn slhkdllgai sgiaspytts tpninsvrna
     1261 dsrgslistd sgnslperns eksnsldkhq qsstlgnsvv rcdkldqsei ksllmcflyi
     1321 lksmsddalf tywnkastse lmdfftisev clhqfqymgk ryiasvrkis svlgisvdng
     1381 yghsdadvlh qslleaniat evcltaldtl slftlafknq lladhghnpl mkkvfdvylc
     1441 flqkhqseta lknvftalrs liykfpstfy egradmcaal cyeilkccns klssirteas
     1501 qllyflmrnn fdytgkksfv rthlqviisv sqliadvvgi ggtrfqqsls iinncansdr
     1561 likhtsfssd vkdltkrirt vlmataqmke hendpemlvd lqyslaksya stpelrktwl
     1621 dsmarihvkn gdlseaamcy vhvtalvaey ltrkgvfrqg ctafrvitpn ideeasmmed
     1681 vgmqdvhfne dvlmelleqc adglwkaery eliadiykli ipiyekrrdf erlahlydtl
     1741 hrayskvtev mhsgrrllgt yfrvaffgqa aqyqftdset dvegffeded gkeyiykepk
     1801 ltplseisqr llklysdkfg senvkmiqds gkvnpkdlds kyayiqvthv ipffdekelq
     1861 erktefersh nirrfmfemp ftqtgkrqgg veeqckrrti ltaihcfpyv kkripvmyqh
     1921 htdlnpieva idemskkvae lrqlcssaev dmiklqlklq gsvsvqvnag playarafld
     1981 dtntkrypdn kvkllkevfr qfveacgqal avnerliked qleyqeemka nyremakels
     2041 eimheqicpl eektsvlpns lhifnaisgt ptstmvhgmt ssssvv
//
LOCUS       XP_047286187            2122 aa            linear   PRI 05-AUG-2025
DEFINITION  dedicator of cytokinesis protein 9 isoform X12 [Homo sapiens].
ACCESSION   XP_047286187
VERSION     XP_047286187.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430231.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2122
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..2122
                     /product="dedicator of cytokinesis protein 9 isoform X12"
                     /calculated_mol_wt=242088
     Region          38..148
                     /region_name="DOCK_C-D_N"
                     /note="Dedicator of cytokinesis C/D, N terminal;
                     pfam11878"
                     /db_xref="CDD:463380"
     Region          162..285
                     /region_name="PH_DOCK-D"
                     /note="Dedicator of cytokinesis-D subfamily Pleckstrin
                     homology (PH) domain; cd13267"
                     /db_xref="CDD:270087"
     Region          631..820
                     /region_name="C2_Dock-D"
                     /note="C2 domains found in Dedicator Of CytoKinesis (Dock)
                     class C proteins; cd08697"
                     /db_xref="CDD:176079"
     Region          1627..2078
                     /region_name="DHR2_DOCK9"
                     /note="Dock Homology Region 2, a GEF domain, of Class D
                     Dedicator of Cytokinesis 9; cd11698"
                     /db_xref="CDD:212571"
     Site            order(1754,1764,1766..1767,1769..1770,1773..1774,
                     1776..1777,1780..1781)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            order(1788..1791,1793,1836..1837,1839..1842,1844..1845,
                     1864..1866,1883,1885,1914,1916,1923..1924,1930,1969..1970,
                     1973,1987,1989,1993,1996..1998,2001..2004,2006..2007,2010,
                     2038,2056..2057,2059..2060,2063)
                     /site_type="other"
                     /note="Cdc42 binding site [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            2001..2006
                     /site_type="other"
                     /note="nucleotide sensor"
                     /db_xref="CDD:212571"
     CDS             1..2122
                     /gene="DOCK9"
                     /gene_synonym="ZIZ1; ZIZIMIN1"
                     /coded_by="XM_047430231.1:678..7046"
                     /db_xref="GeneID:23348"
                     /db_xref="HGNC:HGNC:14132"
                     /db_xref="MIM:607325"
ORIGIN      
        1 maamkplgiw aggaagilpk lgfqdhhslr rptrqakpkl iepldyenvi vqkktqilnd
       61 clremllfpy ddfqtailrr qgryicstvp akaeeeaqsl fvteciktyn sdwhlvnyky
      121 edysgefrql pnkvvkldkl pvhvyevdee vdkdedaasl gsqkggitkh gwlykgnmns
      181 aisvtmrsfk rrffhliqlg dgsynlnfyk dekiskepkg sifldscmgv vqnnkvrrfa
      241 felkmqdkss yllaadseve meewitilnk ilqlnfeaam qekrngdshe ddeqsklegs
      301 gsgldsylpe laksareaei klksesrvkl fyldpdaqkl dfssaepevk sfeekfgkri
      361 lvkcndlsfn lqccvaenee gpttnvepff vtlslfdiky nrkisadfhv dlnhfsvrqm
      421 lattspalmn gsgqspsvlk gilheaamqy pkqgifsvtc phpdiflvar iekvlqgsit
      481 hcaepymkss dsskvaqkvl knakqacqrl gqyrmpfawa artlfkdasg nldknarfsa
      541 iyrqdsnkls nddmlkllad frkpekmakl pvilgnldit idnvssdfpn yvnssyiptk
      601 qfetcsktpi tfeveefvpc ipkhtqpyti ytnhlyvypk ylkydsqksf akarniaici
      661 efkdsdeeds qplkciygrp ggpvftrsaf aavlhhhqnp efydeikiel ptqlhekhhl
      721 lltffhvscd nsskgstkkr dvvetqvgys wlpllkdgrv vtseqhipvs anlpsgylgy
      781 qelgmgrhyg peikwvdggk pllkisthlv stvytqdqhl hnffqycqkt esgaqalgne
      841 lvkylkslha meghvmiafl ptilnqlfrv ltratqeeva vnvtrviihv vaqcheegle
      901 shlrsyvkya ykaepyvase yktvheeltk smttilkpsa dfltsnkllk yswfffdvli
      961 ksmaqhlien skvkllrnqr fpasyhhave tvvnmlmphi tqkfrdnpea sknanhslav
     1021 fikrcftfmd rgfvfkqinn yiscfapgdp ktlfeykfef lrvvcnhehy iplnlpmpfg
     1081 kgriqryqdl qldysltdef crnhflvgll lrevgtalqe frevrliais vlknllikhs
     1141 fddryasrsh qariatlylp lfgllienvq rinvrdvspf pvnagmtvkd eslalpavnp
     1201 lvtpqkgstl dnslhkdllg aisgiaspyt tstpninsvr nadsrgslis tdsgnslper
     1261 nseksnsldk hqqsstlgns vvrcdkldqs eiksllmcfl yilksmsdda lftywnkast
     1321 selmdfftis evclhqfqym gkryiarnqe glgpivhdrk sqtlpvsrnr tgmmharlqq
     1381 lgsldnsltf nhsyghsdad vlhqsllean iatevcltal dtlslftlaf knqlladhgh
     1441 nplmkkvfdv ylcflqkhqs etalknvfta lrsliykfps tfyegradmc aalcyeilkc
     1501 cnsklssirt easqllyflm rnnfdytgkk sfvrthlqvi isvsqliadv vgiggtrfqq
     1561 slsiinncan sdrlikhtsf ssdvkdltkr irtvlmataq mkehendpem lvdlqyslak
     1621 syastpelrk twldsmarih vkngdlseaa mcyvhvtalv aeyltrkeav qweppllphs
     1681 hsaclrrsrg gvfrqgctaf rvitpnidee asmmedvgmq dvhfnedvlm elleqcadgl
     1741 wkaeryelia diykliipiy ekrrdferla hlydtlhray skvtevmhsg rrllgtyfrv
     1801 affgqaaqyq ftdsetdveg ffededgkey iykepkltpl seisqrllkl ysdkfgsenv
     1861 kmiqdsgkvn pkdldskyay iqvthvipff dekelqerkt efershnirr fmfempftqt
     1921 gkrqggveeq ckrrtiltai hcfpyvkkri pvmyqhhtdl npievaidem skkvaelrql
     1981 cssaevdmik lqlklqgsvs vqvnagplay araflddtnt krypdnkvkl lkevfrqfve
     2041 acgqalavne rlikedqley qeemkanyre makelseimh eqicpleekt svlpnslhif
     2101 naisgtptst mvhgmtssss vv
//
LOCUS       XP_047286188            2118 aa            linear   PRI 05-AUG-2025
DEFINITION  dedicator of cytokinesis protein 9 isoform X13 [Homo sapiens].
ACCESSION   XP_047286188
VERSION     XP_047286188.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430232.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2118
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..2118
                     /product="dedicator of cytokinesis protein 9 isoform X13"
                     /calculated_mol_wt=241979
     Region          57..167
                     /region_name="DOCK_C-D_N"
                     /note="Dedicator of cytokinesis C/D, N terminal;
                     pfam11878"
                     /db_xref="CDD:463380"
     Region          181..304
                     /region_name="PH_DOCK-D"
                     /note="Dedicator of cytokinesis-D subfamily Pleckstrin
                     homology (PH) domain; cd13267"
                     /db_xref="CDD:270087"
     Region          650..839
                     /region_name="C2_Dock-D"
                     /note="C2 domains found in Dedicator Of CytoKinesis (Dock)
                     class C proteins; cd08697"
                     /db_xref="CDD:176079"
     Region          1623..2074
                     /region_name="DHR2_DOCK9"
                     /note="Dock Homology Region 2, a GEF domain, of Class D
                     Dedicator of Cytokinesis 9; cd11698"
                     /db_xref="CDD:212571"
     Site            order(1750,1760,1762..1763,1765..1766,1769..1770,
                     1772..1773,1776..1777)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            order(1784..1787,1789,1832..1833,1835..1838,1840..1841,
                     1860..1862,1879,1881,1910,1912,1919..1920,1926,1965..1966,
                     1969,1983,1985,1989,1992..1994,1997..2000,2002..2003,2006,
                     2034,2052..2053,2055..2056,2059)
                     /site_type="other"
                     /note="Cdc42 binding site [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            1997..2002
                     /site_type="other"
                     /note="nucleotide sensor"
                     /db_xref="CDD:212571"
     CDS             1..2118
                     /gene="DOCK9"
                     /gene_synonym="ZIZ1; ZIZIMIN1"
                     /coded_by="XM_047430232.1:178..6534"
                     /db_xref="GeneID:23348"
                     /db_xref="HGNC:HGNC:14132"
                     /db_xref="MIM:607325"
ORIGIN      
        1 mgcttsvilf kgirtvfern caymckqqge nnaleytayn wtkedselli sswlakpkli
       61 epldyenviv qkktqilndc lremllfpyd dfqtailrrq gryicstvpa kaeeeaqslf
      121 vteciktyns dwhlvnykye dysgefrqlp nkvvkldklp vhvyevdeev dkdedaaslg
      181 sqkggitkhg wlykgnmnsa isvtmrsfkr rffhliqlgd gsynlnfykd ekiskepkgs
      241 ifldscmgvv qnnkvrrfaf elkmqdkssy llaadsevem eewitilnki lqlnfeaamq
      301 ekrngdshed deqsklegsg sgldsylpel aksareaeik lksesrvklf yldpdaqkld
      361 fssaepevks feekfgkril vkcndlsfnl qccvaeneeg pttnvepffv tlslfdikyn
      421 rkisadfhvd lnhfsvrqml attspalmng sgqspsvlkg ilheaamqyp kqgifsvtcp
      481 hpdiflvari ekvlqgsith caepymkssd sskvaqkvlk nakqacqrlg qyrmpfawaa
      541 rtlfkdasgn ldknarfsai yrqdsnklsn ddmlklladf rkpekmaklp vilgnlditi
      601 dnvssdfpny vnssyiptkq fetcsktpit feveefvpci pkhtqpytiy tnhlyvypky
      661 lkydsqksfa karniaicie fkdsdeedsq plkciygrpg gpvftrsafa avlhhhqnpe
      721 fydeikielp tqlhekhhll ltffhvscdn sskgstkkrd vvetqvgysw lpllkdgrvv
      781 tseqhipvsa nlpsgylgyq elgmgrhygp eikwvdggkp llkisthlvs tvytqdqhlh
      841 nffqycqkte sgaqalgnel vkylkslham eghvmiaflp tilnqlfrvl tratqeevav
      901 nvtrviihvv aqcheegles hlrsyvkyay kaepyvasey ktvheeltks mttilkpsad
      961 fltsnkllky swfffdvlik smaqhliens kvkllrnqrf pasyhhavet vvnmlmphit
     1021 qkfrdnpeas knanhslavf ikrcftfmdr gfvfkqinny iscfapgdpk tlfeykfefl
     1081 rvvcnhehyi plnlpmpfgk griqryqdlq ldysltdefc rnhflvglll revgtalqef
     1141 revrliaisv lknllikhsf ddryasrshq ariatlylpl fgllienvqr invrdvspfp
     1201 vnagmtvkde slalpavnpl vtpqkgstld nslhkdllga isgiaspytt stpninsvrn
     1261 adsrgslist dsgnslpern seksnsldkh qqsstlgnsv vrcdkldqse iksllmcfly
     1321 ilksmsddal ftywnkasts elmdfftise vclhqfqymg kryiartgmm harlqqlgsl
     1381 dnsltfnhsy ghsdadvlhq slleaniate vcltaldtls lftlafknql ladhghnplm
     1441 kkvfdvylcf lqkhqsetal knvftalrsl iykfpstfye gradmcaalc yeilkccnsk
     1501 lssirteasq llyflmrnnf dytgkksfvr thlqviisvs qliadvvgig gtrfqqslsi
     1561 inncansdrl ikhtsfssdv kdltkrirtv lmataqmkeh endpemlvdl qyslaksyas
     1621 tpelrktwld smarihvkng dlseaamcyv hvtalvaeyl trkeavqwep pllphshsac
     1681 lrrsrggvfr qgctafrvit pnideeasmm edvgmqdvhf nedvlmelle qcadglwkae
     1741 ryeliadiyk liipiyekrr dferlahlyd tlhrayskvt evmhsgrrll gtyfrvaffg
     1801 qaaqyqftds etdvegffed edgkeyiyke pkltplseis qrllklysdk fgsenvkmiq
     1861 dsgkvnpkdl dskyayiqvt hvipffdeke lqerktefer shnirrfmfe mpftqtgkrq
     1921 ggveeqckrr tiltaihcfp yvkkripvmy qhhtdlnpie vaidemskkv aelrqlcssa
     1981 evdmiklqlk lqgsvsvqvn agplayaraf lddtntkryp dnkvkllkev frqfveacgq
     2041 alavnerlik edqleyqeem kanyremake lseimheqic pleektsvlp nslhifnais
     2101 gtptstmvhg mtssssvv
//
LOCUS       XP_016876000            2080 aa            linear   PRI 05-AUG-2025
DEFINITION  dedicator of cytokinesis protein 9 isoform X14 [Homo sapiens].
ACCESSION   XP_016876000
VERSION     XP_016876000.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020511.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2080
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..2080
                     /product="dedicator of cytokinesis protein 9 isoform X14"
                     /calculated_mol_wt=237786
     Region          56..166
                     /region_name="DOCK_C-D_N"
                     /note="Dedicator of cytokinesis C/D, N terminal;
                     pfam11878"
                     /db_xref="CDD:463380"
     Region          180..303
                     /region_name="PH_DOCK-D"
                     /note="Dedicator of cytokinesis-D subfamily Pleckstrin
                     homology (PH) domain; cd13267"
                     /db_xref="CDD:270087"
     Region          649..838
                     /region_name="C2_Dock-D"
                     /note="C2 domains found in Dedicator Of CytoKinesis (Dock)
                     class C proteins; cd08697"
                     /db_xref="CDD:176079"
     Region          1622..2036
                     /region_name="DHR2_DOCK9"
                     /note="Dock Homology Region 2, a GEF domain, of Class D
                     Dedicator of Cytokinesis 9; cd11698"
                     /db_xref="CDD:212571"
     Site            order(1726,1736,1738..1739,1741..1742,1745..1746,
                     1748..1749,1752..1753)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            order(1760..1763,1765,1794..1795,1797..1800,1802..1803,
                     1822..1824,1841,1843,1872,1874,1881..1882,1888,1927..1928,
                     1931,1945,1947,1951,1954..1956,1959..1962,1964..1965,1968,
                     1996,2014..2015,2017..2018,2021)
                     /site_type="other"
                     /note="Cdc42 binding site [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            1959..1964
                     /site_type="other"
                     /note="nucleotide sensor"
                     /db_xref="CDD:212571"
     CDS             1..2080
                     /gene="DOCK9"
                     /gene_synonym="ZIZ1; ZIZIMIN1"
                     /coded_by="XM_017020511.2:16..6258"
                     /db_xref="GeneID:23348"
                     /db_xref="HGNC:HGNC:14132"
                     /db_xref="MIM:607325"
ORIGIN      
        1 mgtyllvalp cfnhqpgiwf ltitqmkafq nwknfrtsrq pccllsstsf rfkakpklie
       61 pldyenvivq kktqilndcl remllfpydd fqtailrrqg ryicstvpak aeeeaqslfv
      121 teciktynsd whlvnykyed ysgefrqlpn kvvkldklpv hvyevdeevd kdedaaslgs
      181 qkggitkhgw lykgnmnsai svtmrsfkrr ffhliqlgdg synlnfykde kiskepkgsi
      241 fldscmgvvq nnkvrrfafe lkmqdkssyl laadseveme ewitilnkil qlnfeaamqe
      301 krngdshedd eqsklegsgs gldsylpela ksareaeikl ksesrvklfy ldpdaqkldf
      361 ssaepevksf eekfgkrilv kcndlsfnlq ccvaeneegp ttnvepffvt lslfdikynr
      421 kisadfhvdl nhfsvrqmla ttspalmngs gqspsvlkgi lheaamqypk qgifsvtcph
      481 pdiflvarie kvlqgsithc aepymkssds skvaqkvlkn akqacqrlgq yrmpfawaar
      541 tlfkdasgnl dknarfsaiy rqdsnklsnd dmlklladfr kpekmaklpv ilgnlditid
      601 nvssdfpnyv nssyiptkqf etcsktpitf eveefvpcip khtqpytiyt nhlyvypkyl
      661 kydsqksfak arniaicief kdsdeedsqp lkciygrpgg pvftrsafaa vlhhhqnpef
      721 ydeikielpt qlhekhhlll tffhvscdns skgstkkrdv vetqvgyswl pllkdgrvvt
      781 seqhipvsan lpsgylgyqe lgmgrhygpe ikwvdggkpl lkisthlvst vytqdqhlhn
      841 ffqycqktes gaqalgnelv kylkslhame ghvmiaflpt ilnqlfrvlt ratqeevavn
      901 vtrviihvva qcheeglesh lrsyvkyayk aepyvaseyk tvheeltksm ttilkpsadf
      961 ltsnkllkys wfffdvliks maqhliensk vkllrnqrfp asyhhavetv vnmlmphitq
     1021 kfrdnpeask nanhslavfi krcftfmdrg fvfkqinnyi scfapgdpkt lfeykfeflr
     1081 vvcnhehyip lnlpmpfgkg riqryqdlql dysltdefcr nhflvglllr evgtalqefr
     1141 evrliaisvl knllikhsfd dryasrshqa riatlylplf gllienvqri nvrdvspfpv
     1201 nagmtvkdes lalpavnplv tpqkgstldn slhkdllgai sgiaspytts tpninsvrna
     1261 dsrgslistd sgnslperns eksnsldkhq qsstlgnsvv rcdkldqsei ksllmcflyi
     1321 lksmsddalf tywnkastse lmdfftisev clhqfqymgk ryiartgmmh arlqqlgsld
     1381 nsltfnhsyg hsdadvlhqs lleaniatev cltaldtlsl ftlafknqll adhghnplmk
     1441 kvfdvylcfl qkhqsetalk nvftalrsli ykfpstfyeg radmcaalcy eilkccnskl
     1501 ssirteasql lyflmrnnfd ytgkksfvrt hlqviisvsq liadvvgigg trfqqslsii
     1561 nncansdrli khtsfssdvk dltkrirtvl mataqmkehe ndpemlvdlq yslaksyast
     1621 pelrktwlds marihvkngd lseaamcyvh vtalvaeylt rkgvfrqgct afrvitpnid
     1681 eeasmmedvg mqdvhfnedv lmelleqcad glwkaeryel iadiykliip iyekrrdfer
     1741 lahlydtlhr ayskvtevmh sgrrllgtyf rvaffgqgff ededgkeyiy kepkltplse
     1801 isqrllklys dkfgsenvkm iqdsgkvnpk dldskyayiq vthvipffde kelqerktef
     1861 ershnirrfm fempftqtgk rqggveeqck rrtiltaihc fpyvkkripv myqhhtdlnp
     1921 ievaidemsk kvaelrqlcs saevdmiklq lklqgsvsvq vnagplayar aflddtntkr
     1981 ypdnkvkllk evfrqfveac gqalavnerl ikedqleyqe emkanyrema kelseimheq
     2041 icpleektsv lpnslhifna isgtptstmv hgmtssssvv
//
LOCUS       XP_047286190            2116 aa            linear   PRI 05-AUG-2025
DEFINITION  dedicator of cytokinesis protein 9 isoform X15 [Homo sapiens].
ACCESSION   XP_047286190
VERSION     XP_047286190.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430234.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 4% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2116
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..2116
                     /product="dedicator of cytokinesis protein 9 isoform X15"
                     /calculated_mol_wt=241300
     Region          46..156
                     /region_name="DOCK_C-D_N"
                     /note="Dedicator of cytokinesis C/D, N terminal;
                     pfam11878"
                     /db_xref="CDD:463380"
     Region          170..293
                     /region_name="PH_DOCK-D"
                     /note="Dedicator of cytokinesis-D subfamily Pleckstrin
                     homology (PH) domain; cd13267"
                     /db_xref="CDD:270087"
     Region          639..828
                     /region_name="C2_Dock-D"
                     /note="C2 domains found in Dedicator Of CytoKinesis (Dock)
                     class C proteins; cd08697"
                     /db_xref="CDD:176079"
     Region          1635..2072
                     /region_name="DHR2_DOCK9"
                     /note="Dock Homology Region 2, a GEF domain, of Class D
                     Dedicator of Cytokinesis 9; cd11698"
                     /db_xref="CDD:212571"
     Site            order(1762,1772,1774..1775,1777..1778,1781..1782,
                     1784..1785,1788..1789)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            order(1796..1799,1801,1830..1831,1833..1836,1838..1839,
                     1858..1860,1877,1879,1908,1910,1917..1918,1924,1963..1964,
                     1967,1981,1983,1987,1990..1992,1995..1998,2000..2001,2004,
                     2032,2050..2051,2053..2054,2057)
                     /site_type="other"
                     /note="Cdc42 binding site [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            1995..2000
                     /site_type="other"
                     /note="nucleotide sensor"
                     /db_xref="CDD:212571"
     CDS             1..2116
                     /gene="DOCK9"
                     /gene_synonym="ZIZ1; ZIZIMIN1"
                     /coded_by="XM_047430234.1:344..6694"
                     /db_xref="GeneID:23348"
                     /db_xref="HGNC:HGNC:14132"
                     /db_xref="MIM:607325"
ORIGIN      
        1 msqppllpas aetrkftral skpgtaaelr qsvsevvrgs vllakpklie pldyenvivq
       61 kktqilndcl remllfpydd fqtailrrqg ryicstvpak aeeeaqslfv teciktynsd
      121 whlvnykyed ysgefrqlpn kvvkldklpv hvyevdeevd kdedaaslgs qkggitkhgw
      181 lykgnmnsai svtmrsfkrr ffhliqlgdg synlnfykde kiskepkgsi fldscmgvvq
      241 nnkvrrfafe lkmqdkssyl laadseveme ewitilnkil qlnfeaamqe krngdshedd
      301 eqsklegsgs gldsylpela ksareaeikl ksesrvklfy ldpdaqkldf ssaepevksf
      361 eekfgkrilv kcndlsfnlq ccvaeneegp ttnvepffvt lslfdikynr kisadfhvdl
      421 nhfsvrqmla ttspalmngs gqspsvlkgi lheaamqypk qgifsvtcph pdiflvarie
      481 kvlqgsithc aepymkssds skvaqkvlkn akqacqrlgq yrmpfawaar tlfkdasgnl
      541 dknarfsaiy rqdsnklsnd dmlklladfr kpekmaklpv ilgnlditid nvssdfpnyv
      601 nssyiptkqf etcsktpitf eveefvpcip khtqpytiyt nhlyvypkyl kydsqksfak
      661 arniaicief kdsdeedsqp lkciygrpgg pvftrsafaa vlhhhqnpef ydeikielpt
      721 qlhekhhlll tffhvscdns skgstkkrdv vetqvgyswl pllkdgrvvt seqhipvsan
      781 lpsgylgyqe lgmgrhygpe ikwvdggkpl lkisthlvst vytqdqhlhn ffqycqktes
      841 gaqalgnelv kylkslhame ghvmiaflpt ilnqlfrvlt ratqeevavn vtrviihvva
      901 qcheeglesh lrsyvkyayk aepyvaseyk tvheeltksm ttilkpsadf ltsnkllkys
      961 wfffdvliks maqhliensk vkllrnqrfp asyhhavetv vnmlmphitq kfrdnpeask
     1021 nanhslavfi krcftfmdrg fvfkqinnyi scfapgdpkt lfeykfeflr vvcnhehyip
     1081 lnlpmpfgkg riqryqdlql dysltdefcr nhflvglllr evgtalqefr evrliaisvl
     1141 knllikhsfd dryasrshqa riatlylplf gllienvqri nvrdvspfpv nagmtvkdes
     1201 lalpavnplv tpqkgstldn slhkdllgai sgiaspytts tpninsvrna dsrgslistd
     1261 sgnslperns eksnsldkhq qsstlgnsvv rcdkldqsei ksllmcflyi lksmsddalf
     1321 tywnkastse lmdfftisev clhqfqymgk ryiarnqegl gpivhdrksq tlpvsrnrtg
     1381 mmharlqqlg sldnsltfnh syghsdadvl hqslleania tevcltaldt lslftlafkn
     1441 qlladhghnp lmkkvfdvyl cflqkhqset alknvftalr sliykfpstf yegradmcaa
     1501 lcyeilkccn sklssirtea sqllyflmrn nfdytgkksf vrthlqviis vsqliadvvg
     1561 iggtrfqqsl siinncansd rlikhtsfss dvkdltkrir tvlmataqmk ehendpemlv
     1621 dlqyslaksy astpelrktw ldsmarihvk ngdlseaamc yvhvtalvae yltrkeavqw
     1681 eppllphshs aclrrsrggv frqgctafrv itpnideeas mmedvgmqdv hfnedvlmel
     1741 leqcadglwk aeryeliadi ykliipiyek rrdferlahl ydtlhraysk vtevmhsgrr
     1801 llgtyfrvaf fgqgffeded gkeyiykepk ltplseisqr llklysdkfg senvkmiqds
     1861 gkvnpkdlds kyayiqvthv ipffdekelq erktefersh nirrfmfemp ftqtgkrqgg
     1921 veeqckrrti ltaihcfpyv kkripvmyqh htdlnpieva idemskkvae lrqlcssaev
     1981 dmiklqlklq gsvsvqvnag playarafld dtntkrypdn kvkllkevfr qfveacgqal
     2041 avnerliked qleyqeemka nyremakels eimheqicpl eektsvlpns lhifnaisgt
     2101 ptstmvhgmt ssssvv
//
LOCUS       XP_016876002            2072 aa            linear   PRI 05-AUG-2025
DEFINITION  dedicator of cytokinesis protein 9 isoform X16 [Homo sapiens].
ACCESSION   XP_016876002
VERSION     XP_016876002.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020513.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2072
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..2072
                     /product="dedicator of cytokinesis protein 9 isoform X16"
                     /calculated_mol_wt=236702
     Region          56..166
                     /region_name="DOCK_C-D_N"
                     /note="Dedicator of cytokinesis C/D, N terminal;
                     pfam11878"
                     /db_xref="CDD:463380"
     Region          180..303
                     /region_name="PH_DOCK-D"
                     /note="Dedicator of cytokinesis-D subfamily Pleckstrin
                     homology (PH) domain; cd13267"
                     /db_xref="CDD:270087"
     Region          649..838
                     /region_name="C2_Dock-D"
                     /note="C2 domains found in Dedicator Of CytoKinesis (Dock)
                     class C proteins; cd08697"
                     /db_xref="CDD:176079"
     Region          1614..2028
                     /region_name="DHR2_DOCK9"
                     /note="Dock Homology Region 2, a GEF domain, of Class D
                     Dedicator of Cytokinesis 9; cd11698"
                     /db_xref="CDD:212571"
     Site            order(1718,1728,1730..1731,1733..1734,1737..1738,
                     1740..1741,1744..1745)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            order(1752..1755,1757,1786..1787,1789..1792,1794..1795,
                     1814..1816,1833,1835,1864,1866,1873..1874,1880,1919..1920,
                     1923,1937,1939,1943,1946..1948,1951..1954,1956..1957,1960,
                     1988,2006..2007,2009..2010,2013)
                     /site_type="other"
                     /note="Cdc42 binding site [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            1951..1956
                     /site_type="other"
                     /note="nucleotide sensor"
                     /db_xref="CDD:212571"
     CDS             1..2072
                     /gene="DOCK9"
                     /gene_synonym="ZIZ1; ZIZIMIN1"
                     /coded_by="XM_017020513.2:16..6234"
                     /db_xref="GeneID:23348"
                     /db_xref="HGNC:HGNC:14132"
                     /db_xref="MIM:607325"
ORIGIN      
        1 mgtyllvalp cfnhqpgiwf ltitqmkafq nwknfrtsrq pccllsstsf rfkakpklie
       61 pldyenvivq kktqilndcl remllfpydd fqtailrrqg ryicstvpak aeeeaqslfv
      121 teciktynsd whlvnykyed ysgefrqlpn kvvkldklpv hvyevdeevd kdedaaslgs
      181 qkggitkhgw lykgnmnsai svtmrsfkrr ffhliqlgdg synlnfykde kiskepkgsi
      241 fldscmgvvq nnkvrrfafe lkmqdkssyl laadseveme ewitilnkil qlnfeaamqe
      301 krngdshedd eqsklegsgs gldsylpela ksareaeikl ksesrvklfy ldpdaqkldf
      361 ssaepevksf eekfgkrilv kcndlsfnlq ccvaeneegp ttnvepffvt lslfdikynr
      421 kisadfhvdl nhfsvrqmla ttspalmngs gqspsvlkgi lheaamqypk qgifsvtcph
      481 pdiflvarie kvlqgsithc aepymkssds skvaqkvlkn akqacqrlgq yrmpfawaar
      541 tlfkdasgnl dknarfsaiy rqdsnklsnd dmlklladfr kpekmaklpv ilgnlditid
      601 nvssdfpnyv nssyiptkqf etcsktpitf eveefvpcip khtqpytiyt nhlyvypkyl
      661 kydsqksfak arniaicief kdsdeedsqp lkciygrpgg pvftrsafaa vlhhhqnpef
      721 ydeikielpt qlhekhhlll tffhvscdns skgstkkrdv vetqvgyswl pllkdgrvvt
      781 seqhipvsan lpsgylgyqe lgmgrhygpe ikwvdggkpl lkisthlvst vytqdqhlhn
      841 ffqycqktes gaqalgnelv kylkslhame ghvmiaflpt ilnqlfrvlt ratqeevavn
      901 vtrviihvva qcheeglesh lrsyvkyayk aepyvaseyk tvheeltksm ttilkpsadf
      961 ltsnkllkys wfffdvliks maqhliensk vkllrnqrfp asyhhavetv vnmlmphitq
     1021 kfrdnpeask nanhslavfi krcftfmdrg fvfkqinnyi scfapgdpkt lfeykfeflr
     1081 vvcnhehyip lnlpmpfgkg riqryqdlql dysltdefcr nhflvglllr evgtalqefr
     1141 evrliaisvl knllikhsfd dryasrshqa riatlylplf gllienvqri nvrdvspfpv
     1201 nagmtvkdes lalpavnplv tpqkgstldn slhkdllgai sgiaspytts tpninsvrna
     1261 dsrgslistd sgnslperns eksnsldkhq qsstlgnsvv rcdkldqsei ksllmcflyi
     1321 lksmsddalf tywnkastse lmdfftisev clhqfqymgk ryiasvrkis svlgisvdng
     1381 yghsdadvlh qslleaniat evcltaldtl slftlafknq lladhghnpl mkkvfdvylc
     1441 flqkhqseta lknvftalrs liykfpstfy egradmcaal cyeilkccns klssirteas
     1501 qllyflmrnn fdytgkksfv rthlqviisv sqliadvvgi ggtrfqqsls iinncansdr
     1561 likhtsfssd vkdltkrirt vlmataqmke hendpemlvd lqyslaksya stpelrktwl
     1621 dsmarihvkn gdlseaamcy vhvtalvaey ltrkgvfrqg ctafrvitpn ideeasmmed
     1681 vgmqdvhfne dvlmelleqc adglwkaery eliadiykli ipiyekrrdf erlahlydtl
     1741 hrayskvtev mhsgrrllgt yfrvaffgqg ffededgkey iykepkltpl seisqrllkl
     1801 ysdkfgsenv kmiqdsgkvn pkdldskyay iqvthvipff dekelqerkt efershnirr
     1861 fmfempftqt gkrqggveeq ckrrtiltai hcfpyvkkri pvmyqhhtdl npievaidem
     1921 skkvaelrql cssaevdmik lqlklqgsvs vqvnagplay araflddtnt krypdnkvkl
     1981 lkevfrqfve acgqalavne rlikedqley qeemkanyre makelseimh eqicpleekt
     2041 svlpnslhif naisgtptst mvhgmtssss vv
//
LOCUS       XP_006719994            2107 aa            linear   PRI 05-AUG-2025
DEFINITION  dedicator of cytokinesis protein 9 isoform X17 [Homo sapiens].
ACCESSION   XP_006719994
VERSION     XP_006719994.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006719931.4
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 4% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2107
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..2107
                     /product="dedicator of cytokinesis protein 9 isoform X17"
                     /calculated_mol_wt=240301
     Region          46..156
                     /region_name="DOCK_C-D_N"
                     /note="Dedicator of cytokinesis C/D, N terminal;
                     pfam11878"
                     /db_xref="CDD:463380"
     Region          170..293
                     /region_name="PH_DOCK-D"
                     /note="Dedicator of cytokinesis-D subfamily Pleckstrin
                     homology (PH) domain; cd13267"
                     /db_xref="CDD:270087"
     Region          639..828
                     /region_name="C2_Dock-D"
                     /note="C2 domains found in Dedicator Of CytoKinesis (Dock)
                     class C proteins; cd08697"
                     /db_xref="CDD:176079"
     Region          1612..2063
                     /region_name="DHR2_DOCK9"
                     /note="Dock Homology Region 2, a GEF domain, of Class D
                     Dedicator of Cytokinesis 9; cd11698"
                     /db_xref="CDD:212571"
     Site            order(1739,1749,1751..1752,1754..1755,1758..1759,
                     1761..1762,1765..1766)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            order(1773..1776,1778,1821..1822,1824..1827,1829..1830,
                     1849..1851,1868,1870,1899,1901,1908..1909,1915,1954..1955,
                     1958,1972,1974,1978,1981..1983,1986..1989,1991..1992,1995,
                     2023,2041..2042,2044..2045,2048)
                     /site_type="other"
                     /note="Cdc42 binding site [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            1986..1991
                     /site_type="other"
                     /note="nucleotide sensor"
                     /db_xref="CDD:212571"
     CDS             1..2107
                     /gene="DOCK9"
                     /gene_synonym="ZIZ1; ZIZIMIN1"
                     /coded_by="XM_006719931.4:344..6667"
                     /db_xref="GeneID:23348"
                     /db_xref="HGNC:HGNC:14132"
                     /db_xref="MIM:607325"
ORIGIN      
        1 msqppllpas aetrkftral skpgtaaelr qsvsevvrgs vllakpklie pldyenvivq
       61 kktqilndcl remllfpydd fqtailrrqg ryicstvpak aeeeaqslfv teciktynsd
      121 whlvnykyed ysgefrqlpn kvvkldklpv hvyevdeevd kdedaaslgs qkggitkhgw
      181 lykgnmnsai svtmrsfkrr ffhliqlgdg synlnfykde kiskepkgsi fldscmgvvq
      241 nnkvrrfafe lkmqdkssyl laadseveme ewitilnkil qlnfeaamqe krngdshedd
      301 eqsklegsgs gldsylpela ksareaeikl ksesrvklfy ldpdaqkldf ssaepevksf
      361 eekfgkrilv kcndlsfnlq ccvaeneegp ttnvepffvt lslfdikynr kisadfhvdl
      421 nhfsvrqmla ttspalmngs gqspsvlkgi lheaamqypk qgifsvtcph pdiflvarie
      481 kvlqgsithc aepymkssds skvaqkvlkn akqacqrlgq yrmpfawaar tlfkdasgnl
      541 dknarfsaiy rqdsnklsnd dmlklladfr kpekmaklpv ilgnlditid nvssdfpnyv
      601 nssyiptkqf etcsktpitf eveefvpcip khtqpytiyt nhlyvypkyl kydsqksfak
      661 arniaicief kdsdeedsqp lkciygrpgg pvftrsafaa vlhhhqnpef ydeikielpt
      721 qlhekhhlll tffhvscdns skgstkkrdv vetqvgyswl pllkdgrvvt seqhipvsan
      781 lpsgylgyqe lgmgrhygpe ikwvdggkpl lkisthlvst vytqdqhlhn ffqycqktes
      841 gaqalgnelv kylkslhame ghvmiaflpt ilnqlfrvlt ratqeevavn vtrviihvva
      901 qcheeglesh lrsyvkyayk aepyvaseyk tvheeltksm ttilkpsadf ltsnkllkys
      961 wfffdvliks maqhliensk vkllrnqrfp asyhhavetv vnmlmphitq kfrdnpeask
     1021 nanhslavfi krcftfmdrg fvfkqinnyi scfapgdpkt lfeykfeflr vvcnhehyip
     1081 lnlpmpfgkg riqryqdlql dysltdefcr nhflvglllr evgtalqefr evrliaisvl
     1141 knllikhsfd dryasrshqa riatlylplf gllienvqri nvrdvspfpv nagmtvkdes
     1201 lalpavnplv tpqkgstldn slhkdllgai sgiaspytts tpninsvrna dsrgslistd
     1261 sgnslperns eksnsldkhq qsstlgnsvv rcdkldqsei ksllmcflyi lksmsddalf
     1321 tywnkastse lmdfftisev clhqfqymgk ryiartgmmh arlqqlgsld nsltfnhsyg
     1381 hsdadvlhqs lleaniatev cltaldtlsl ftlafknqll adhghnplmk kvfdvylcfl
     1441 qkhqsetalk nvftalrsli ykfpstfyeg radmcaalcy eilkccnskl ssirteasql
     1501 lyflmrnnfd ytgkksfvrt hlqviisvsq liadvvgigg trfqqslsii nncansdrli
     1561 khtsfssdvk dltkrirtvl mataqmkehe ndpemlvdlq yslaksyast pelrktwlds
     1621 marihvkngd lseaamcyvh vtalvaeylt rkeavqwepp llphshsacl rrsrggvfrq
     1681 gctafrvitp nideeasmme dvgmqdvhfn edvlmelleq cadglwkaer yeliadiykl
     1741 iipiyekrrd ferlahlydt lhrayskvte vmhsgrrllg tyfrvaffgq aaqyqftdse
     1801 tdvegffede dgkeyiykep kltplseisq rllklysdkf gsenvkmiqd sgkvnpkdld
     1861 skyayiqvth vipffdekel qerktefers hnirrfmfem pftqtgkrqg gveeqckrrt
     1921 iltaihcfpy vkkripvmyq hhtdlnpiev aidemskkva elrqlcssae vdmiklqlkl
     1981 qgsvsvqvna gplayarafl ddtntkrypd nkvkllkevf rqfveacgqa lavnerlike
     2041 dqleyqeemk anyremakel seimheqicp leektsvlpn slhifnaisg tptstmvhgm
     2101 tssssvv
//
LOCUS       XP_006719995            2106 aa            linear   PRI 05-AUG-2025
DEFINITION  dedicator of cytokinesis protein 9 isoform X18 [Homo sapiens].
ACCESSION   XP_006719995
VERSION     XP_006719995.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006719932.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2106
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..2106
                     /product="dedicator of cytokinesis protein 9 isoform X18"
                     /calculated_mol_wt=240281
     Region          45..155
                     /region_name="DOCK_C-D_N"
                     /note="Dedicator of cytokinesis C/D, N terminal;
                     pfam11878"
                     /db_xref="CDD:463380"
     Region          169..292
                     /region_name="PH_DOCK-D"
                     /note="Dedicator of cytokinesis-D subfamily Pleckstrin
                     homology (PH) domain; cd13267"
                     /db_xref="CDD:270087"
     Region          638..827
                     /region_name="C2_Dock-D"
                     /note="C2 domains found in Dedicator Of CytoKinesis (Dock)
                     class C proteins; cd08697"
                     /db_xref="CDD:176079"
     Region          1611..2062
                     /region_name="DHR2_DOCK9"
                     /note="Dock Homology Region 2, a GEF domain, of Class D
                     Dedicator of Cytokinesis 9; cd11698"
                     /db_xref="CDD:212571"
     Site            order(1738,1748,1750..1751,1753..1754,1757..1758,
                     1760..1761,1764..1765)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            order(1772..1775,1777,1820..1821,1823..1826,1828..1829,
                     1848..1850,1867,1869,1898,1900,1907..1908,1914,1953..1954,
                     1957,1971,1973,1977,1980..1982,1985..1988,1990..1991,1994,
                     2022,2040..2041,2043..2044,2047)
                     /site_type="other"
                     /note="Cdc42 binding site [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            1985..1990
                     /site_type="other"
                     /note="nucleotide sensor"
                     /db_xref="CDD:212571"
     CDS             1..2106
                     /gene="DOCK9"
                     /gene_synonym="ZIZ1; ZIZIMIN1"
                     /coded_by="XM_006719932.2:156..6476"
                     /db_xref="GeneID:23348"
                     /db_xref="HGNC:HGNC:14132"
                     /db_xref="MIM:607325"
ORIGIN      
        1 mqadkcrtss rsvkkelvie splqykdaaq geveaespgp vpakpkliep ldyenvivqk
       61 ktqilndclr emllfpyddf qtailrrqgr yicstvpaka eeeaqslfvt eciktynsdw
      121 hlvnykyedy sgefrqlpnk vvkldklpvh vyevdeevdk dedaaslgsq kggitkhgwl
      181 ykgnmnsais vtmrsfkrrf fhliqlgdgs ynlnfykdek iskepkgsif ldscmgvvqn
      241 nkvrrfafel kmqdkssyll aadsevemee witilnkilq lnfeaamqek rngdshedde
      301 qsklegsgsg ldsylpelak sareaeiklk sesrvklfyl dpdaqkldfs saepevksfe
      361 ekfgkrilvk cndlsfnlqc cvaeneegpt tnvepffvtl slfdikynrk isadfhvdln
      421 hfsvrqmlat tspalmngsg qspsvlkgil heaamqypkq gifsvtcphp diflvariek
      481 vlqgsithca epymkssdss kvaqkvlkna kqacqrlgqy rmpfawaart lfkdasgnld
      541 knarfsaiyr qdsnklsndd mlklladfrk pekmaklpvi lgnlditidn vssdfpnyvn
      601 ssyiptkqfe tcsktpitfe veefvpcipk htqpytiytn hlyvypkylk ydsqksfaka
      661 rniaiciefk dsdeedsqpl kciygrpggp vftrsafaav lhhhqnpefy deikielptq
      721 lhekhhlllt ffhvscdnss kgstkkrdvv etqvgyswlp llkdgrvvts eqhipvsanl
      781 psgylgyqel gmgrhygpei kwvdggkpll kisthlvstv ytqdqhlhnf fqycqktesg
      841 aqalgnelvk ylkslhameg hvmiaflpti lnqlfrvltr atqeevavnv trviihvvaq
      901 cheegleshl rsyvkyayka epyvaseykt vheeltksmt tilkpsadfl tsnkllkysw
      961 fffdvliksm aqhlienskv kllrnqrfpa syhhavetvv nmlmphitqk frdnpeaskn
     1021 anhslavfik rcftfmdrgf vfkqinnyis cfapgdpktl feykfeflrv vcnhehyipl
     1081 nlpmpfgkgr iqryqdlqld ysltdefcrn hflvglllre vgtalqefre vrliaisvlk
     1141 nllikhsfdd ryasrshqar iatlylplfg llienvqrin vrdvspfpvn agmtvkdesl
     1201 alpavnplvt pqkgstldns lhkdllgais giaspyttst pninsvrnad srgslistds
     1261 gnslpernse ksnsldkhqq sstlgnsvvr cdkldqseik sllmcflyil ksmsddalft
     1321 ywnkastsel mdfftisevc lhqfqymgkr yiartgmmha rlqqlgsldn sltfnhsygh
     1381 sdadvlhqsl leaniatevc ltaldtlslf tlafknqlla dhghnplmkk vfdvylcflq
     1441 khqsetalkn vftalrsliy kfpstfyegr admcaalcye ilkccnskls sirteasqll
     1501 yflmrnnfdy tgkksfvrth lqviisvsql iadvvgiggt rfqqslsiin ncansdrlik
     1561 htsfssdvkd ltkrirtvlm ataqmkehen dpemlvdlqy slaksyastp elrktwldsm
     1621 arihvkngdl seaamcyvhv talvaeyltr keavqweppl lphshsaclr rsrggvfrqg
     1681 ctafrvitpn ideeasmmed vgmqdvhfne dvlmelleqc adglwkaery eliadiykli
     1741 ipiyekrrdf erlahlydtl hrayskvtev mhsgrrllgt yfrvaffgqa aqyqftdset
     1801 dvegffeded gkeyiykepk ltplseisqr llklysdkfg senvkmiqds gkvnpkdlds
     1861 kyayiqvthv ipffdekelq erktefersh nirrfmfemp ftqtgkrqgg veeqckrrti
     1921 ltaihcfpyv kkripvmyqh htdlnpieva idemskkvae lrqlcssaev dmiklqlklq
     1981 gsvsvqvnag playarafld dtntkrypdn kvkllkevfr qfveacgqal avnerliked
     2041 qleyqeemka nyremakels eimheqicpl eektsvlpns lhifnaisgt ptstmvhgmt
     2101 ssssvv
//
LOCUS       XP_016876004            2098 aa            linear   PRI 05-AUG-2025
DEFINITION  dedicator of cytokinesis protein 9 isoform X19 [Homo sapiens].
ACCESSION   XP_016876004
VERSION     XP_016876004.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020515.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2098
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..2098
                     /product="dedicator of cytokinesis protein 9 isoform X19"
                     /calculated_mol_wt=239197
     Region          45..155
                     /region_name="DOCK_C-D_N"
                     /note="Dedicator of cytokinesis C/D, N terminal;
                     pfam11878"
                     /db_xref="CDD:463380"
     Region          169..292
                     /region_name="PH_DOCK-D"
                     /note="Dedicator of cytokinesis-D subfamily Pleckstrin
                     homology (PH) domain; cd13267"
                     /db_xref="CDD:270087"
     Region          638..827
                     /region_name="C2_Dock-D"
                     /note="C2 domains found in Dedicator Of CytoKinesis (Dock)
                     class C proteins; cd08697"
                     /db_xref="CDD:176079"
     Region          1603..2054
                     /region_name="DHR2_DOCK9"
                     /note="Dock Homology Region 2, a GEF domain, of Class D
                     Dedicator of Cytokinesis 9; cd11698"
                     /db_xref="CDD:212571"
     Site            order(1730,1740,1742..1743,1745..1746,1749..1750,
                     1752..1753,1756..1757)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            order(1764..1767,1769,1812..1813,1815..1818,1820..1821,
                     1840..1842,1859,1861,1890,1892,1899..1900,1906,1945..1946,
                     1949,1963,1965,1969,1972..1974,1977..1980,1982..1983,1986,
                     2014,2032..2033,2035..2036,2039)
                     /site_type="other"
                     /note="Cdc42 binding site [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            1977..1982
                     /site_type="other"
                     /note="nucleotide sensor"
                     /db_xref="CDD:212571"
     CDS             1..2098
                     /gene="DOCK9"
                     /gene_synonym="ZIZ1; ZIZIMIN1"
                     /coded_by="XM_017020515.2:156..6452"
                     /db_xref="GeneID:23348"
                     /db_xref="HGNC:HGNC:14132"
                     /db_xref="MIM:607325"
ORIGIN      
        1 mqadkcrtss rsvkkelvie splqykdaaq geveaespgp vpakpkliep ldyenvivqk
       61 ktqilndclr emllfpyddf qtailrrqgr yicstvpaka eeeaqslfvt eciktynsdw
      121 hlvnykyedy sgefrqlpnk vvkldklpvh vyevdeevdk dedaaslgsq kggitkhgwl
      181 ykgnmnsais vtmrsfkrrf fhliqlgdgs ynlnfykdek iskepkgsif ldscmgvvqn
      241 nkvrrfafel kmqdkssyll aadsevemee witilnkilq lnfeaamqek rngdshedde
      301 qsklegsgsg ldsylpelak sareaeiklk sesrvklfyl dpdaqkldfs saepevksfe
      361 ekfgkrilvk cndlsfnlqc cvaeneegpt tnvepffvtl slfdikynrk isadfhvdln
      421 hfsvrqmlat tspalmngsg qspsvlkgil heaamqypkq gifsvtcphp diflvariek
      481 vlqgsithca epymkssdss kvaqkvlkna kqacqrlgqy rmpfawaart lfkdasgnld
      541 knarfsaiyr qdsnklsndd mlklladfrk pekmaklpvi lgnlditidn vssdfpnyvn
      601 ssyiptkqfe tcsktpitfe veefvpcipk htqpytiytn hlyvypkylk ydsqksfaka
      661 rniaiciefk dsdeedsqpl kciygrpggp vftrsafaav lhhhqnpefy deikielptq
      721 lhekhhlllt ffhvscdnss kgstkkrdvv etqvgyswlp llkdgrvvts eqhipvsanl
      781 psgylgyqel gmgrhygpei kwvdggkpll kisthlvstv ytqdqhlhnf fqycqktesg
      841 aqalgnelvk ylkslhameg hvmiaflpti lnqlfrvltr atqeevavnv trviihvvaq
      901 cheegleshl rsyvkyayka epyvaseykt vheeltksmt tilkpsadfl tsnkllkysw
      961 fffdvliksm aqhlienskv kllrnqrfpa syhhavetvv nmlmphitqk frdnpeaskn
     1021 anhslavfik rcftfmdrgf vfkqinnyis cfapgdpktl feykfeflrv vcnhehyipl
     1081 nlpmpfgkgr iqryqdlqld ysltdefcrn hflvglllre vgtalqefre vrliaisvlk
     1141 nllikhsfdd ryasrshqar iatlylplfg llienvqrin vrdvspfpvn agmtvkdesl
     1201 alpavnplvt pqkgstldns lhkdllgais giaspyttst pninsvrnad srgslistds
     1261 gnslpernse ksnsldkhqq sstlgnsvvr cdkldqseik sllmcflyil ksmsddalft
     1321 ywnkastsel mdfftisevc lhqfqymgkr yiasvrkiss vlgisvdngy ghsdadvlhq
     1381 slleaniate vcltaldtls lftlafknql ladhghnplm kkvfdvylcf lqkhqsetal
     1441 knvftalrsl iykfpstfye gradmcaalc yeilkccnsk lssirteasq llyflmrnnf
     1501 dytgkksfvr thlqviisvs qliadvvgig gtrfqqslsi inncansdrl ikhtsfssdv
     1561 kdltkrirtv lmataqmkeh endpemlvdl qyslaksyas tpelrktwld smarihvkng
     1621 dlseaamcyv hvtalvaeyl trkeavqwep pllphshsac lrrsrggvfr qgctafrvit
     1681 pnideeasmm edvgmqdvhf nedvlmelle qcadglwkae ryeliadiyk liipiyekrr
     1741 dferlahlyd tlhrayskvt evmhsgrrll gtyfrvaffg qaaqyqftds etdvegffed
     1801 edgkeyiyke pkltplseis qrllklysdk fgsenvkmiq dsgkvnpkdl dskyayiqvt
     1861 hvipffdeke lqerktefer shnirrfmfe mpftqtgkrq ggveeqckrr tiltaihcfp
     1921 yvkkripvmy qhhtdlnpie vaidemskkv aelrqlcssa evdmiklqlk lqgsvsvqvn
     1981 agplayaraf lddtntkryp dnkvkllkev frqfveacgq alavnerlik edqleyqeem
     2041 kanyremake lseimheqic pleektsvlp nslhifnais gtptstmvhg mtssssvv
//
LOCUS       XP_006719999            2095 aa            linear   PRI 05-AUG-2025
DEFINITION  dedicator of cytokinesis protein 9 isoform X20 [Homo sapiens].
ACCESSION   XP_006719999
VERSION     XP_006719999.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006719936.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2095
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..2095
                     /product="dedicator of cytokinesis protein 9 isoform X20"
                     /calculated_mol_wt=239370
     Region          57..167
                     /region_name="DOCK_C-D_N"
                     /note="Dedicator of cytokinesis C/D, N terminal;
                     pfam11878"
                     /db_xref="CDD:463380"
     Region          181..304
                     /region_name="PH_DOCK-D"
                     /note="Dedicator of cytokinesis-D subfamily Pleckstrin
                     homology (PH) domain; cd13267"
                     /db_xref="CDD:270087"
     Region          650..839
                     /region_name="C2_Dock-D"
                     /note="C2 domains found in Dedicator Of CytoKinesis (Dock)
                     class C proteins; cd08697"
                     /db_xref="CDD:176079"
     Region          1623..2051
                     /region_name="DHR2_DOCK9"
                     /note="Dock Homology Region 2, a GEF domain, of Class D
                     Dedicator of Cytokinesis 9; cd11698"
                     /db_xref="CDD:212571"
     Site            order(1727,1737,1739..1740,1742..1743,1746..1747,
                     1749..1750,1753..1754)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            order(1761..1764,1766,1809..1810,1812..1815,1817..1818,
                     1837..1839,1856,1858,1887,1889,1896..1897,1903,1942..1943,
                     1946,1960,1962,1966,1969..1971,1974..1977,1979..1980,1983,
                     2011,2029..2030,2032..2033,2036)
                     /site_type="other"
                     /note="Cdc42 binding site [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            1974..1979
                     /site_type="other"
                     /note="nucleotide sensor"
                     /db_xref="CDD:212571"
     CDS             1..2095
                     /gene="DOCK9"
                     /gene_synonym="ZIZ1; ZIZIMIN1"
                     /coded_by="XM_006719936.2:178..6465"
                     /db_xref="GeneID:23348"
                     /db_xref="HGNC:HGNC:14132"
                     /db_xref="MIM:607325"
ORIGIN      
        1 mgcttsvilf kgirtvfern caymckqqge nnaleytayn wtkedselli sswlakpkli
       61 epldyenviv qkktqilndc lremllfpyd dfqtailrrq gryicstvpa kaeeeaqslf
      121 vteciktyns dwhlvnykye dysgefrqlp nkvvkldklp vhvyevdeev dkdedaaslg
      181 sqkggitkhg wlykgnmnsa isvtmrsfkr rffhliqlgd gsynlnfykd ekiskepkgs
      241 ifldscmgvv qnnkvrrfaf elkmqdkssy llaadsevem eewitilnki lqlnfeaamq
      301 ekrngdshed deqsklegsg sgldsylpel aksareaeik lksesrvklf yldpdaqkld
      361 fssaepevks feekfgkril vkcndlsfnl qccvaeneeg pttnvepffv tlslfdikyn
      421 rkisadfhvd lnhfsvrqml attspalmng sgqspsvlkg ilheaamqyp kqgifsvtcp
      481 hpdiflvari ekvlqgsith caepymkssd sskvaqkvlk nakqacqrlg qyrmpfawaa
      541 rtlfkdasgn ldknarfsai yrqdsnklsn ddmlklladf rkpekmaklp vilgnlditi
      601 dnvssdfpny vnssyiptkq fetcsktpit feveefvpci pkhtqpytiy tnhlyvypky
      661 lkydsqksfa karniaicie fkdsdeedsq plkciygrpg gpvftrsafa avlhhhqnpe
      721 fydeikielp tqlhekhhll ltffhvscdn sskgstkkrd vvetqvgysw lpllkdgrvv
      781 tseqhipvsa nlpsgylgyq elgmgrhygp eikwvdggkp llkisthlvs tvytqdqhlh
      841 nffqycqkte sgaqalgnel vkylkslham eghvmiaflp tilnqlfrvl tratqeevav
      901 nvtrviihvv aqcheegles hlrsyvkyay kaepyvasey ktvheeltks mttilkpsad
      961 fltsnkllky swfffdvlik smaqhliens kvkllrnqrf pasyhhavet vvnmlmphit
     1021 qkfrdnpeas knanhslavf ikrcftfmdr gfvfkqinny iscfapgdpk tlfeykfefl
     1081 rvvcnhehyi plnlpmpfgk griqryqdlq ldysltdefc rnhflvglll revgtalqef
     1141 revrliaisv lknllikhsf ddryasrshq ariatlylpl fgllienvqr invrdvspfp
     1201 vnagmtvkde slalpavnpl vtpqkgstld nslhkdllga isgiaspytt stpninsvrn
     1261 adsrgslist dsgnslpern seksnsldkh qqsstlgnsv vrcdkldqse iksllmcfly
     1321 ilksmsddal ftywnkasts elmdfftise vclhqfqymg kryiartgmm harlqqlgsl
     1381 dnsltfnhsy ghsdadvlhq slleaniate vcltaldtls lftlafknql ladhghnplm
     1441 kkvfdvylcf lqkhqsetal knvftalrsl iykfpstfye gradmcaalc yeilkccnsk
     1501 lssirteasq llyflmrnnf dytgkksfvr thlqviisvs qliadvvgig gtrfqqslsi
     1561 inncansdrl ikhtsfssdv kdltkrirtv lmataqmkeh endpemlvdl qyslaksyas
     1621 tpelrktwld smarihvkng dlseaamcyv hvtalvaeyl trkgvfrqgc tafrvitpni
     1681 deeasmmedv gmqdvhfned vlmelleqca dglwkaerye liadiyklii piyekrrdfe
     1741 rlahlydtlh rayskvtevm hsgrrllgty frvaffgqaa qyqftdsetd vegffededg
     1801 keyiykepkl tplseisqrl lklysdkfgs envkmiqdsg kvnpkdldsk yayiqvthvi
     1861 pffdekelqe rktefershn irrfmfempf tqtgkrqggv eeqckrrtil taihcfpyvk
     1921 kripvmyqhh tdlnpievai demskkvael rqlcssaevd miklqlklqg svsvqvnagp
     1981 layarafldd tntkrypdnk vkllkevfrq fveacgqala vnerlikedq leyqeemkan
     2041 yremakelse imheqicple ektsvlpnsl hifnaisgtp tstmvhgmts sssvv
//
LOCUS       XP_005254091            2093 aa            linear   PRI 05-AUG-2025
DEFINITION  dedicator of cytokinesis protein 9 isoform X21 [Homo sapiens].
ACCESSION   XP_005254091
VERSION     XP_005254091.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254034.4
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 4% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2093
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..2093
                     /product="dedicator of cytokinesis protein 9 isoform X21"
                     /calculated_mol_wt=238691
     Region          46..156
                     /region_name="DOCK_C-D_N"
                     /note="Dedicator of cytokinesis C/D, N terminal;
                     pfam11878"
                     /db_xref="CDD:463380"
     Region          170..293
                     /region_name="PH_DOCK-D"
                     /note="Dedicator of cytokinesis-D subfamily Pleckstrin
                     homology (PH) domain; cd13267"
                     /db_xref="CDD:270087"
     Region          639..828
                     /region_name="C2_Dock-D"
                     /note="C2 domains found in Dedicator Of CytoKinesis (Dock)
                     class C proteins; cd08697"
                     /db_xref="CDD:176079"
     Region          1635..2049
                     /region_name="DHR2_DOCK9"
                     /note="Dock Homology Region 2, a GEF domain, of Class D
                     Dedicator of Cytokinesis 9; cd11698"
                     /db_xref="CDD:212571"
     Site            order(1739,1749,1751..1752,1754..1755,1758..1759,
                     1761..1762,1765..1766)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            order(1773..1776,1778,1807..1808,1810..1813,1815..1816,
                     1835..1837,1854,1856,1885,1887,1894..1895,1901,1940..1941,
                     1944,1958,1960,1964,1967..1969,1972..1975,1977..1978,1981,
                     2009,2027..2028,2030..2031,2034)
                     /site_type="other"
                     /note="Cdc42 binding site [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            1972..1977
                     /site_type="other"
                     /note="nucleotide sensor"
                     /db_xref="CDD:212571"
     CDS             1..2093
                     /gene="DOCK9"
                     /gene_synonym="ZIZ1; ZIZIMIN1"
                     /coded_by="XM_005254034.4:344..6625"
                     /db_xref="GeneID:23348"
                     /db_xref="HGNC:HGNC:14132"
                     /db_xref="MIM:607325"
ORIGIN      
        1 msqppllpas aetrkftral skpgtaaelr qsvsevvrgs vllakpklie pldyenvivq
       61 kktqilndcl remllfpydd fqtailrrqg ryicstvpak aeeeaqslfv teciktynsd
      121 whlvnykyed ysgefrqlpn kvvkldklpv hvyevdeevd kdedaaslgs qkggitkhgw
      181 lykgnmnsai svtmrsfkrr ffhliqlgdg synlnfykde kiskepkgsi fldscmgvvq
      241 nnkvrrfafe lkmqdkssyl laadseveme ewitilnkil qlnfeaamqe krngdshedd
      301 eqsklegsgs gldsylpela ksareaeikl ksesrvklfy ldpdaqkldf ssaepevksf
      361 eekfgkrilv kcndlsfnlq ccvaeneegp ttnvepffvt lslfdikynr kisadfhvdl
      421 nhfsvrqmla ttspalmngs gqspsvlkgi lheaamqypk qgifsvtcph pdiflvarie
      481 kvlqgsithc aepymkssds skvaqkvlkn akqacqrlgq yrmpfawaar tlfkdasgnl
      541 dknarfsaiy rqdsnklsnd dmlklladfr kpekmaklpv ilgnlditid nvssdfpnyv
      601 nssyiptkqf etcsktpitf eveefvpcip khtqpytiyt nhlyvypkyl kydsqksfak
      661 arniaicief kdsdeedsqp lkciygrpgg pvftrsafaa vlhhhqnpef ydeikielpt
      721 qlhekhhlll tffhvscdns skgstkkrdv vetqvgyswl pllkdgrvvt seqhipvsan
      781 lpsgylgyqe lgmgrhygpe ikwvdggkpl lkisthlvst vytqdqhlhn ffqycqktes
      841 gaqalgnelv kylkslhame ghvmiaflpt ilnqlfrvlt ratqeevavn vtrviihvva
      901 qcheeglesh lrsyvkyayk aepyvaseyk tvheeltksm ttilkpsadf ltsnkllkys
      961 wfffdvliks maqhliensk vkllrnqrfp asyhhavetv vnmlmphitq kfrdnpeask
     1021 nanhslavfi krcftfmdrg fvfkqinnyi scfapgdpkt lfeykfeflr vvcnhehyip
     1081 lnlpmpfgkg riqryqdlql dysltdefcr nhflvglllr evgtalqefr evrliaisvl
     1141 knllikhsfd dryasrshqa riatlylplf gllienvqri nvrdvspfpv nagmtvkdes
     1201 lalpavnplv tpqkgstldn slhkdllgai sgiaspytts tpninsvrna dsrgslistd
     1261 sgnslperns eksnsldkhq qsstlgnsvv rcdkldqsei ksllmcflyi lksmsddalf
     1321 tywnkastse lmdfftisev clhqfqymgk ryiarnqegl gpivhdrksq tlpvsrnrtg
     1381 mmharlqqlg sldnsltfnh syghsdadvl hqslleania tevcltaldt lslftlafkn
     1441 qlladhghnp lmkkvfdvyl cflqkhqset alknvftalr sliykfpstf yegradmcaa
     1501 lcyeilkccn sklssirtea sqllyflmrn nfdytgkksf vrthlqviis vsqliadvvg
     1561 iggtrfqqsl siinncansd rlikhtsfss dvkdltkrir tvlmataqmk ehendpemlv
     1621 dlqyslaksy astpelrktw ldsmarihvk ngdlseaamc yvhvtalvae yltrkgvfrq
     1681 gctafrvitp nideeasmme dvgmqdvhfn edvlmelleq cadglwkaer yeliadiykl
     1741 iipiyekrrd ferlahlydt lhrayskvte vmhsgrrllg tyfrvaffgq gffededgke
     1801 yiykepkltp lseisqrllk lysdkfgsen vkmiqdsgkv npkdldskya yiqvthvipf
     1861 fdekelqerk tefershnir rfmfempftq tgkrqggvee qckrrtilta ihcfpyvkkr
     1921 ipvmyqhhtd lnpievaide mskkvaelrq lcssaevdmi klqlklqgsv svqvnagpla
     1981 yaraflddtn tkrypdnkvk llkevfrqfv eacgqalavn erlikedqle yqeemkanyr
     2041 emakelseim heqicpleek tsvlpnslhi fnaisgtpts tmvhgmtsss svv
//
LOCUS       XP_047286191            2093 aa            linear   PRI 05-AUG-2025
DEFINITION  dedicator of cytokinesis protein 9 isoform X22 [Homo sapiens].
ACCESSION   XP_047286191
VERSION     XP_047286191.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430235.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 4% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2093
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..2093
                     /product="dedicator of cytokinesis protein 9 isoform X22"
                     /calculated_mol_wt=238716
     Region          46..156
                     /region_name="DOCK_C-D_N"
                     /note="Dedicator of cytokinesis C/D, N terminal;
                     pfam11878"
                     /db_xref="CDD:463380"
     Region          170..293
                     /region_name="PH_DOCK-D"
                     /note="Dedicator of cytokinesis-D subfamily Pleckstrin
                     homology (PH) domain; cd13267"
                     /db_xref="CDD:270087"
     Region          639..828
                     /region_name="C2_Dock-D"
                     /note="C2 domains found in Dedicator Of CytoKinesis (Dock)
                     class C proteins; cd08697"
                     /db_xref="CDD:176079"
     Region          1612..2049
                     /region_name="DHR2_DOCK9"
                     /note="Dock Homology Region 2, a GEF domain, of Class D
                     Dedicator of Cytokinesis 9; cd11698"
                     /db_xref="CDD:212571"
     Site            order(1739,1749,1751..1752,1754..1755,1758..1759,
                     1761..1762,1765..1766)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            order(1773..1776,1778,1807..1808,1810..1813,1815..1816,
                     1835..1837,1854,1856,1885,1887,1894..1895,1901,1940..1941,
                     1944,1958,1960,1964,1967..1969,1972..1975,1977..1978,1981,
                     2009,2027..2028,2030..2031,2034)
                     /site_type="other"
                     /note="Cdc42 binding site [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            1972..1977
                     /site_type="other"
                     /note="nucleotide sensor"
                     /db_xref="CDD:212571"
     CDS             1..2093
                     /gene="DOCK9"
                     /gene_synonym="ZIZ1; ZIZIMIN1"
                     /coded_by="XM_047430235.1:344..6625"
                     /db_xref="GeneID:23348"
                     /db_xref="HGNC:HGNC:14132"
                     /db_xref="MIM:607325"
ORIGIN      
        1 msqppllpas aetrkftral skpgtaaelr qsvsevvrgs vllakpklie pldyenvivq
       61 kktqilndcl remllfpydd fqtailrrqg ryicstvpak aeeeaqslfv teciktynsd
      121 whlvnykyed ysgefrqlpn kvvkldklpv hvyevdeevd kdedaaslgs qkggitkhgw
      181 lykgnmnsai svtmrsfkrr ffhliqlgdg synlnfykde kiskepkgsi fldscmgvvq
      241 nnkvrrfafe lkmqdkssyl laadseveme ewitilnkil qlnfeaamqe krngdshedd
      301 eqsklegsgs gldsylpela ksareaeikl ksesrvklfy ldpdaqkldf ssaepevksf
      361 eekfgkrilv kcndlsfnlq ccvaeneegp ttnvepffvt lslfdikynr kisadfhvdl
      421 nhfsvrqmla ttspalmngs gqspsvlkgi lheaamqypk qgifsvtcph pdiflvarie
      481 kvlqgsithc aepymkssds skvaqkvlkn akqacqrlgq yrmpfawaar tlfkdasgnl
      541 dknarfsaiy rqdsnklsnd dmlklladfr kpekmaklpv ilgnlditid nvssdfpnyv
      601 nssyiptkqf etcsktpitf eveefvpcip khtqpytiyt nhlyvypkyl kydsqksfak
      661 arniaicief kdsdeedsqp lkciygrpgg pvftrsafaa vlhhhqnpef ydeikielpt
      721 qlhekhhlll tffhvscdns skgstkkrdv vetqvgyswl pllkdgrvvt seqhipvsan
      781 lpsgylgyqe lgmgrhygpe ikwvdggkpl lkisthlvst vytqdqhlhn ffqycqktes
      841 gaqalgnelv kylkslhame ghvmiaflpt ilnqlfrvlt ratqeevavn vtrviihvva
      901 qcheeglesh lrsyvkyayk aepyvaseyk tvheeltksm ttilkpsadf ltsnkllkys
      961 wfffdvliks maqhliensk vkllrnqrfp asyhhavetv vnmlmphitq kfrdnpeask
     1021 nanhslavfi krcftfmdrg fvfkqinnyi scfapgdpkt lfeykfeflr vvcnhehyip
     1081 lnlpmpfgkg riqryqdlql dysltdefcr nhflvglllr evgtalqefr evrliaisvl
     1141 knllikhsfd dryasrshqa riatlylplf gllienvqri nvrdvspfpv nagmtvkdes
     1201 lalpavnplv tpqkgstldn slhkdllgai sgiaspytts tpninsvrna dsrgslistd
     1261 sgnslperns eksnsldkhq qsstlgnsvv rcdkldqsei ksllmcflyi lksmsddalf
     1321 tywnkastse lmdfftisev clhqfqymgk ryiartgmmh arlqqlgsld nsltfnhsyg
     1381 hsdadvlhqs lleaniatev cltaldtlsl ftlafknqll adhghnplmk kvfdvylcfl
     1441 qkhqsetalk nvftalrsli ykfpstfyeg radmcaalcy eilkccnskl ssirteasql
     1501 lyflmrnnfd ytgkksfvrt hlqviisvsq liadvvgigg trfqqslsii nncansdrli
     1561 khtsfssdvk dltkrirtvl mataqmkehe ndpemlvdlq yslaksyast pelrktwlds
     1621 marihvkngd lseaamcyvh vtalvaeylt rkeavqwepp llphshsacl rrsrggvfrq
     1681 gctafrvitp nideeasmme dvgmqdvhfn edvlmelleq cadglwkaer yeliadiykl
     1741 iipiyekrrd ferlahlydt lhrayskvte vmhsgrrllg tyfrvaffgq gffededgke
     1801 yiykepkltp lseisqrllk lysdkfgsen vkmiqdsgkv npkdldskya yiqvthvipf
     1861 fdekelqerk tefershnir rfmfempftq tgkrqggvee qckrrtilta ihcfpyvkkr
     1921 ipvmyqhhtd lnpievaide mskkvaelrq lcssaevdmi klqlklqgsv svqvnagpla
     1981 yaraflddtn tkrypdnkvk llkevfrqfv eacgqalavn erlikedqle yqeemkanyr
     2041 emakelseim heqicpleek tsvlpnslhi fnaisgtpts tmvhgmtsss svv
//
LOCUS       XP_047286192            2092 aa            linear   PRI 05-AUG-2025
DEFINITION  dedicator of cytokinesis protein 9 isoform X23 [Homo sapiens].
ACCESSION   XP_047286192
VERSION     XP_047286192.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430236.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2092
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..2092
                     /product="dedicator of cytokinesis protein 9 isoform X23"
                     /calculated_mol_wt=238695
     Region          45..155
                     /region_name="DOCK_C-D_N"
                     /note="Dedicator of cytokinesis C/D, N terminal;
                     pfam11878"
                     /db_xref="CDD:463380"
     Region          169..292
                     /region_name="PH_DOCK-D"
                     /note="Dedicator of cytokinesis-D subfamily Pleckstrin
                     homology (PH) domain; cd13267"
                     /db_xref="CDD:270087"
     Region          638..827
                     /region_name="C2_Dock-D"
                     /note="C2 domains found in Dedicator Of CytoKinesis (Dock)
                     class C proteins; cd08697"
                     /db_xref="CDD:176079"
     Region          1611..2048
                     /region_name="DHR2_DOCK9"
                     /note="Dock Homology Region 2, a GEF domain, of Class D
                     Dedicator of Cytokinesis 9; cd11698"
                     /db_xref="CDD:212571"
     Site            order(1738,1748,1750..1751,1753..1754,1757..1758,
                     1760..1761,1764..1765)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            order(1772..1775,1777,1806..1807,1809..1812,1814..1815,
                     1834..1836,1853,1855,1884,1886,1893..1894,1900,1939..1940,
                     1943,1957,1959,1963,1966..1968,1971..1974,1976..1977,1980,
                     2008,2026..2027,2029..2030,2033)
                     /site_type="other"
                     /note="Cdc42 binding site [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            1971..1976
                     /site_type="other"
                     /note="nucleotide sensor"
                     /db_xref="CDD:212571"
     CDS             1..2092
                     /gene="DOCK9"
                     /gene_synonym="ZIZ1; ZIZIMIN1"
                     /coded_by="XM_047430236.1:156..6434"
                     /db_xref="GeneID:23348"
                     /db_xref="HGNC:HGNC:14132"
                     /db_xref="MIM:607325"
ORIGIN      
        1 mqadkcrtss rsvkkelvie splqykdaaq geveaespgp vpakpkliep ldyenvivqk
       61 ktqilndclr emllfpyddf qtailrrqgr yicstvpaka eeeaqslfvt eciktynsdw
      121 hlvnykyedy sgefrqlpnk vvkldklpvh vyevdeevdk dedaaslgsq kggitkhgwl
      181 ykgnmnsais vtmrsfkrrf fhliqlgdgs ynlnfykdek iskepkgsif ldscmgvvqn
      241 nkvrrfafel kmqdkssyll aadsevemee witilnkilq lnfeaamqek rngdshedde
      301 qsklegsgsg ldsylpelak sareaeiklk sesrvklfyl dpdaqkldfs saepevksfe
      361 ekfgkrilvk cndlsfnlqc cvaeneegpt tnvepffvtl slfdikynrk isadfhvdln
      421 hfsvrqmlat tspalmngsg qspsvlkgil heaamqypkq gifsvtcphp diflvariek
      481 vlqgsithca epymkssdss kvaqkvlkna kqacqrlgqy rmpfawaart lfkdasgnld
      541 knarfsaiyr qdsnklsndd mlklladfrk pekmaklpvi lgnlditidn vssdfpnyvn
      601 ssyiptkqfe tcsktpitfe veefvpcipk htqpytiytn hlyvypkylk ydsqksfaka
      661 rniaiciefk dsdeedsqpl kciygrpggp vftrsafaav lhhhqnpefy deikielptq
      721 lhekhhlllt ffhvscdnss kgstkkrdvv etqvgyswlp llkdgrvvts eqhipvsanl
      781 psgylgyqel gmgrhygpei kwvdggkpll kisthlvstv ytqdqhlhnf fqycqktesg
      841 aqalgnelvk ylkslhameg hvmiaflpti lnqlfrvltr atqeevavnv trviihvvaq
      901 cheegleshl rsyvkyayka epyvaseykt vheeltksmt tilkpsadfl tsnkllkysw
      961 fffdvliksm aqhlienskv kllrnqrfpa syhhavetvv nmlmphitqk frdnpeaskn
     1021 anhslavfik rcftfmdrgf vfkqinnyis cfapgdpktl feykfeflrv vcnhehyipl
     1081 nlpmpfgkgr iqryqdlqld ysltdefcrn hflvglllre vgtalqefre vrliaisvlk
     1141 nllikhsfdd ryasrshqar iatlylplfg llienvqrin vrdvspfpvn agmtvkdesl
     1201 alpavnplvt pqkgstldns lhkdllgais giaspyttst pninsvrnad srgslistds
     1261 gnslpernse ksnsldkhqq sstlgnsvvr cdkldqseik sllmcflyil ksmsddalft
     1321 ywnkastsel mdfftisevc lhqfqymgkr yiartgmmha rlqqlgsldn sltfnhsygh
     1381 sdadvlhqsl leaniatevc ltaldtlslf tlafknqlla dhghnplmkk vfdvylcflq
     1441 khqsetalkn vftalrsliy kfpstfyegr admcaalcye ilkccnskls sirteasqll
     1501 yflmrnnfdy tgkksfvrth lqviisvsql iadvvgiggt rfqqslsiin ncansdrlik
     1561 htsfssdvkd ltkrirtvlm ataqmkehen dpemlvdlqy slaksyastp elrktwldsm
     1621 arihvkngdl seaamcyvhv talvaeyltr keavqweppl lphshsaclr rsrggvfrqg
     1681 ctafrvitpn ideeasmmed vgmqdvhfne dvlmelleqc adglwkaery eliadiykli
     1741 ipiyekrrdf erlahlydtl hrayskvtev mhsgrrllgt yfrvaffgqg ffededgkey
     1801 iykepkltpl seisqrllkl ysdkfgsenv kmiqdsgkvn pkdldskyay iqvthvipff
     1861 dekelqerkt efershnirr fmfempftqt gkrqggveeq ckrrtiltai hcfpyvkkri
     1921 pvmyqhhtdl npievaidem skkvaelrql cssaevdmik lqlklqgsvs vqvnagplay
     1981 araflddtnt krypdnkvkl lkevfrqfve acgqalavne rlikedqley qeemkanyre
     2041 makelseimh eqicpleekt svlpnslhif naisgtptst mvhgmtssss vv
//
LOCUS       XP_047286193            2084 aa            linear   PRI 05-AUG-2025
DEFINITION  dedicator of cytokinesis protein 9 isoform X24 [Homo sapiens].
ACCESSION   XP_047286193
VERSION     XP_047286193.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430237.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2084
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..2084
                     /product="dedicator of cytokinesis protein 9 isoform X24"
                     /calculated_mol_wt=237611
     Region          45..155
                     /region_name="DOCK_C-D_N"
                     /note="Dedicator of cytokinesis C/D, N terminal;
                     pfam11878"
                     /db_xref="CDD:463380"
     Region          169..292
                     /region_name="PH_DOCK-D"
                     /note="Dedicator of cytokinesis-D subfamily Pleckstrin
                     homology (PH) domain; cd13267"
                     /db_xref="CDD:270087"
     Region          638..827
                     /region_name="C2_Dock-D"
                     /note="C2 domains found in Dedicator Of CytoKinesis (Dock)
                     class C proteins; cd08697"
                     /db_xref="CDD:176079"
     Region          1603..2040
                     /region_name="DHR2_DOCK9"
                     /note="Dock Homology Region 2, a GEF domain, of Class D
                     Dedicator of Cytokinesis 9; cd11698"
                     /db_xref="CDD:212571"
     Site            order(1730,1740,1742..1743,1745..1746,1749..1750,
                     1752..1753,1756..1757)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            order(1764..1767,1769,1798..1799,1801..1804,1806..1807,
                     1826..1828,1845,1847,1876,1878,1885..1886,1892,1931..1932,
                     1935,1949,1951,1955,1958..1960,1963..1966,1968..1969,1972,
                     2000,2018..2019,2021..2022,2025)
                     /site_type="other"
                     /note="Cdc42 binding site [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            1963..1968
                     /site_type="other"
                     /note="nucleotide sensor"
                     /db_xref="CDD:212571"
     CDS             1..2084
                     /gene="DOCK9"
                     /gene_synonym="ZIZ1; ZIZIMIN1"
                     /coded_by="XM_047430237.1:156..6410"
                     /db_xref="GeneID:23348"
                     /db_xref="HGNC:HGNC:14132"
                     /db_xref="MIM:607325"
ORIGIN      
        1 mqadkcrtss rsvkkelvie splqykdaaq geveaespgp vpakpkliep ldyenvivqk
       61 ktqilndclr emllfpyddf qtailrrqgr yicstvpaka eeeaqslfvt eciktynsdw
      121 hlvnykyedy sgefrqlpnk vvkldklpvh vyevdeevdk dedaaslgsq kggitkhgwl
      181 ykgnmnsais vtmrsfkrrf fhliqlgdgs ynlnfykdek iskepkgsif ldscmgvvqn
      241 nkvrrfafel kmqdkssyll aadsevemee witilnkilq lnfeaamqek rngdshedde
      301 qsklegsgsg ldsylpelak sareaeiklk sesrvklfyl dpdaqkldfs saepevksfe
      361 ekfgkrilvk cndlsfnlqc cvaeneegpt tnvepffvtl slfdikynrk isadfhvdln
      421 hfsvrqmlat tspalmngsg qspsvlkgil heaamqypkq gifsvtcphp diflvariek
      481 vlqgsithca epymkssdss kvaqkvlkna kqacqrlgqy rmpfawaart lfkdasgnld
      541 knarfsaiyr qdsnklsndd mlklladfrk pekmaklpvi lgnlditidn vssdfpnyvn
      601 ssyiptkqfe tcsktpitfe veefvpcipk htqpytiytn hlyvypkylk ydsqksfaka
      661 rniaiciefk dsdeedsqpl kciygrpggp vftrsafaav lhhhqnpefy deikielptq
      721 lhekhhlllt ffhvscdnss kgstkkrdvv etqvgyswlp llkdgrvvts eqhipvsanl
      781 psgylgyqel gmgrhygpei kwvdggkpll kisthlvstv ytqdqhlhnf fqycqktesg
      841 aqalgnelvk ylkslhameg hvmiaflpti lnqlfrvltr atqeevavnv trviihvvaq
      901 cheegleshl rsyvkyayka epyvaseykt vheeltksmt tilkpsadfl tsnkllkysw
      961 fffdvliksm aqhlienskv kllrnqrfpa syhhavetvv nmlmphitqk frdnpeaskn
     1021 anhslavfik rcftfmdrgf vfkqinnyis cfapgdpktl feykfeflrv vcnhehyipl
     1081 nlpmpfgkgr iqryqdlqld ysltdefcrn hflvglllre vgtalqefre vrliaisvlk
     1141 nllikhsfdd ryasrshqar iatlylplfg llienvqrin vrdvspfpvn agmtvkdesl
     1201 alpavnplvt pqkgstldns lhkdllgais giaspyttst pninsvrnad srgslistds
     1261 gnslpernse ksnsldkhqq sstlgnsvvr cdkldqseik sllmcflyil ksmsddalft
     1321 ywnkastsel mdfftisevc lhqfqymgkr yiasvrkiss vlgisvdngy ghsdadvlhq
     1381 slleaniate vcltaldtls lftlafknql ladhghnplm kkvfdvylcf lqkhqsetal
     1441 knvftalrsl iykfpstfye gradmcaalc yeilkccnsk lssirteasq llyflmrnnf
     1501 dytgkksfvr thlqviisvs qliadvvgig gtrfqqslsi inncansdrl ikhtsfssdv
     1561 kdltkrirtv lmataqmkeh endpemlvdl qyslaksyas tpelrktwld smarihvkng
     1621 dlseaamcyv hvtalvaeyl trkeavqwep pllphshsac lrrsrggvfr qgctafrvit
     1681 pnideeasmm edvgmqdvhf nedvlmelle qcadglwkae ryeliadiyk liipiyekrr
     1741 dferlahlyd tlhrayskvt evmhsgrrll gtyfrvaffg qgffededgk eyiykepklt
     1801 plseisqrll klysdkfgse nvkmiqdsgk vnpkdldsky ayiqvthvip ffdekelqer
     1861 ktefershni rrfmfempft qtgkrqggve eqckrrtilt aihcfpyvkk ripvmyqhht
     1921 dlnpievaid emskkvaelr qlcssaevdm iklqlklqgs vsvqvnagpl ayaraflddt
     1981 ntkrypdnkv kllkevfrqf veacgqalav nerlikedql eyqeemkany remakelsei
     2041 mheqicplee ktsvlpnslh ifnaisgtpt stmvhgmtss ssvv
//
LOCUS       XP_006720000            2084 aa            linear   PRI 05-AUG-2025
DEFINITION  dedicator of cytokinesis protein 9 isoform X25 [Homo sapiens].
ACCESSION   XP_006720000
VERSION     XP_006720000.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006719937.4
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 4% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2084
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..2084
                     /product="dedicator of cytokinesis protein 9 isoform X25"
                     /calculated_mol_wt=237692
     Region          46..156
                     /region_name="DOCK_C-D_N"
                     /note="Dedicator of cytokinesis C/D, N terminal;
                     pfam11878"
                     /db_xref="CDD:463380"
     Region          170..293
                     /region_name="PH_DOCK-D"
                     /note="Dedicator of cytokinesis-D subfamily Pleckstrin
                     homology (PH) domain; cd13267"
                     /db_xref="CDD:270087"
     Region          639..828
                     /region_name="C2_Dock-D"
                     /note="C2 domains found in Dedicator Of CytoKinesis (Dock)
                     class C proteins; cd08697"
                     /db_xref="CDD:176079"
     Region          1612..2040
                     /region_name="DHR2_DOCK9"
                     /note="Dock Homology Region 2, a GEF domain, of Class D
                     Dedicator of Cytokinesis 9; cd11698"
                     /db_xref="CDD:212571"
     Site            order(1716,1726,1728..1729,1731..1732,1735..1736,
                     1738..1739,1742..1743)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            order(1750..1753,1755,1798..1799,1801..1804,1806..1807,
                     1826..1828,1845,1847,1876,1878,1885..1886,1892,1931..1932,
                     1935,1949,1951,1955,1958..1960,1963..1966,1968..1969,1972,
                     2000,2018..2019,2021..2022,2025)
                     /site_type="other"
                     /note="Cdc42 binding site [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            1963..1968
                     /site_type="other"
                     /note="nucleotide sensor"
                     /db_xref="CDD:212571"
     CDS             1..2084
                     /gene="DOCK9"
                     /gene_synonym="ZIZ1; ZIZIMIN1"
                     /coded_by="XM_006719937.4:344..6598"
                     /db_xref="GeneID:23348"
                     /db_xref="HGNC:HGNC:14132"
                     /db_xref="MIM:607325"
ORIGIN      
        1 msqppllpas aetrkftral skpgtaaelr qsvsevvrgs vllakpklie pldyenvivq
       61 kktqilndcl remllfpydd fqtailrrqg ryicstvpak aeeeaqslfv teciktynsd
      121 whlvnykyed ysgefrqlpn kvvkldklpv hvyevdeevd kdedaaslgs qkggitkhgw
      181 lykgnmnsai svtmrsfkrr ffhliqlgdg synlnfykde kiskepkgsi fldscmgvvq
      241 nnkvrrfafe lkmqdkssyl laadseveme ewitilnkil qlnfeaamqe krngdshedd
      301 eqsklegsgs gldsylpela ksareaeikl ksesrvklfy ldpdaqkldf ssaepevksf
      361 eekfgkrilv kcndlsfnlq ccvaeneegp ttnvepffvt lslfdikynr kisadfhvdl
      421 nhfsvrqmla ttspalmngs gqspsvlkgi lheaamqypk qgifsvtcph pdiflvarie
      481 kvlqgsithc aepymkssds skvaqkvlkn akqacqrlgq yrmpfawaar tlfkdasgnl
      541 dknarfsaiy rqdsnklsnd dmlklladfr kpekmaklpv ilgnlditid nvssdfpnyv
      601 nssyiptkqf etcsktpitf eveefvpcip khtqpytiyt nhlyvypkyl kydsqksfak
      661 arniaicief kdsdeedsqp lkciygrpgg pvftrsafaa vlhhhqnpef ydeikielpt
      721 qlhekhhlll tffhvscdns skgstkkrdv vetqvgyswl pllkdgrvvt seqhipvsan
      781 lpsgylgyqe lgmgrhygpe ikwvdggkpl lkisthlvst vytqdqhlhn ffqycqktes
      841 gaqalgnelv kylkslhame ghvmiaflpt ilnqlfrvlt ratqeevavn vtrviihvva
      901 qcheeglesh lrsyvkyayk aepyvaseyk tvheeltksm ttilkpsadf ltsnkllkys
      961 wfffdvliks maqhliensk vkllrnqrfp asyhhavetv vnmlmphitq kfrdnpeask
     1021 nanhslavfi krcftfmdrg fvfkqinnyi scfapgdpkt lfeykfeflr vvcnhehyip
     1081 lnlpmpfgkg riqryqdlql dysltdefcr nhflvglllr evgtalqefr evrliaisvl
     1141 knllikhsfd dryasrshqa riatlylplf gllienvqri nvrdvspfpv nagmtvkdes
     1201 lalpavnplv tpqkgstldn slhkdllgai sgiaspytts tpninsvrna dsrgslistd
     1261 sgnslperns eksnsldkhq qsstlgnsvv rcdkldqsei ksllmcflyi lksmsddalf
     1321 tywnkastse lmdfftisev clhqfqymgk ryiartgmmh arlqqlgsld nsltfnhsyg
     1381 hsdadvlhqs lleaniatev cltaldtlsl ftlafknqll adhghnplmk kvfdvylcfl
     1441 qkhqsetalk nvftalrsli ykfpstfyeg radmcaalcy eilkccnskl ssirteasql
     1501 lyflmrnnfd ytgkksfvrt hlqviisvsq liadvvgigg trfqqslsii nncansdrli
     1561 khtsfssdvk dltkrirtvl mataqmkehe ndpemlvdlq yslaksyast pelrktwlds
     1621 marihvkngd lseaamcyvh vtalvaeylt rkgvfrqgct afrvitpnid eeasmmedvg
     1681 mqdvhfnedv lmelleqcad glwkaeryel iadiykliip iyekrrdfer lahlydtlhr
     1741 ayskvtevmh sgrrllgtyf rvaffgqaaq yqftdsetdv egffededgk eyiykepklt
     1801 plseisqrll klysdkfgse nvkmiqdsgk vnpkdldsky ayiqvthvip ffdekelqer
     1861 ktefershni rrfmfempft qtgkrqggve eqckrrtilt aihcfpyvkk ripvmyqhht
     1921 dlnpievaid emskkvaelr qlcssaevdm iklqlklqgs vsvqvnagpl ayaraflddt
     1981 ntkrypdnkv kllkevfrqf veacgqalav nerlikedql eyqeemkany remakelsei
     2041 mheqicplee ktsvlpnslh ifnaisgtpt stmvhgmtss ssvv
//
LOCUS       XP_047286194            2069 aa            linear   PRI 05-AUG-2025
DEFINITION  dedicator of cytokinesis protein 9 isoform X26 [Homo sapiens].
ACCESSION   XP_047286194
VERSION     XP_047286194.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430238.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2069
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..2069
                     /product="dedicator of cytokinesis protein 9 isoform X26"
                     /calculated_mol_wt=236087
     Region          45..155
                     /region_name="DOCK_C-D_N"
                     /note="Dedicator of cytokinesis C/D, N terminal;
                     pfam11878"
                     /db_xref="CDD:463380"
     Region          169..292
                     /region_name="PH_DOCK-D"
                     /note="Dedicator of cytokinesis-D subfamily Pleckstrin
                     homology (PH) domain; cd13267"
                     /db_xref="CDD:270087"
     Region          638..827
                     /region_name="C2_Dock-D"
                     /note="C2 domains found in Dedicator Of CytoKinesis (Dock)
                     class C proteins; cd08697"
                     /db_xref="CDD:176079"
     Region          1611..2025
                     /region_name="DHR2_DOCK9"
                     /note="Dock Homology Region 2, a GEF domain, of Class D
                     Dedicator of Cytokinesis 9; cd11698"
                     /db_xref="CDD:212571"
     Site            order(1715,1725,1727..1728,1730..1731,1734..1735,
                     1737..1738,1741..1742)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            order(1749..1752,1754,1783..1784,1786..1789,1791..1792,
                     1811..1813,1830,1832,1861,1863,1870..1871,1877,1916..1917,
                     1920,1934,1936,1940,1943..1945,1948..1951,1953..1954,1957,
                     1985,2003..2004,2006..2007,2010)
                     /site_type="other"
                     /note="Cdc42 binding site [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            1948..1953
                     /site_type="other"
                     /note="nucleotide sensor"
                     /db_xref="CDD:212571"
     CDS             1..2069
                     /gene="DOCK9"
                     /gene_synonym="ZIZ1; ZIZIMIN1"
                     /coded_by="XM_047430238.1:156..6365"
                     /db_xref="GeneID:23348"
                     /db_xref="HGNC:HGNC:14132"
                     /db_xref="MIM:607325"
ORIGIN      
        1 mqadkcrtss rsvkkelvie splqykdaaq geveaespgp vpakpkliep ldyenvivqk
       61 ktqilndclr emllfpyddf qtailrrqgr yicstvpaka eeeaqslfvt eciktynsdw
      121 hlvnykyedy sgefrqlpnk vvkldklpvh vyevdeevdk dedaaslgsq kggitkhgwl
      181 ykgnmnsais vtmrsfkrrf fhliqlgdgs ynlnfykdek iskepkgsif ldscmgvvqn
      241 nkvrrfafel kmqdkssyll aadsevemee witilnkilq lnfeaamqek rngdshedde
      301 qsklegsgsg ldsylpelak sareaeiklk sesrvklfyl dpdaqkldfs saepevksfe
      361 ekfgkrilvk cndlsfnlqc cvaeneegpt tnvepffvtl slfdikynrk isadfhvdln
      421 hfsvrqmlat tspalmngsg qspsvlkgil heaamqypkq gifsvtcphp diflvariek
      481 vlqgsithca epymkssdss kvaqkvlkna kqacqrlgqy rmpfawaart lfkdasgnld
      541 knarfsaiyr qdsnklsndd mlklladfrk pekmaklpvi lgnlditidn vssdfpnyvn
      601 ssyiptkqfe tcsktpitfe veefvpcipk htqpytiytn hlyvypkylk ydsqksfaka
      661 rniaiciefk dsdeedsqpl kciygrpggp vftrsafaav lhhhqnpefy deikielptq
      721 lhekhhlllt ffhvscdnss kgstkkrdvv etqvgyswlp llkdgrvvts eqhipvsanl
      781 psgylgyqel gmgrhygpei kwvdggkpll kisthlvstv ytqdqhlhnf fqycqktesg
      841 aqalgnelvk ylkslhameg hvmiaflpti lnqlfrvltr atqeevavnv trviihvvaq
      901 cheegleshl rsyvkyayka epyvaseykt vheeltksmt tilkpsadfl tsnkllkysw
      961 fffdvliksm aqhlienskv kllrnqrfpa syhhavetvv nmlmphitqk frdnpeaskn
     1021 anhslavfik rcftfmdrgf vfkqinnyis cfapgdpktl feykfeflrv vcnhehyipl
     1081 nlpmpfgkgr iqryqdlqld ysltdefcrn hflvglllre vgtalqefre vrliaisvlk
     1141 nllikhsfdd ryasrshqar iatlylplfg llienvqrin vrdvspfpvn agmtvkdesl
     1201 alpavnplvt pqkgstldns lhkdllgais giaspyttst pninsvrnad srgslistds
     1261 gnslpernse ksnsldkhqq sstlgnsvvr cdkldqseik sllmcflyil ksmsddalft
     1321 ywnkastsel mdfftisevc lhqfqymgkr yiartgmmha rlqqlgsldn sltfnhsygh
     1381 sdadvlhqsl leaniatevc ltaldtlslf tlafknqlla dhghnplmkk vfdvylcflq
     1441 khqsetalkn vftalrsliy kfpstfyegr admcaalcye ilkccnskls sirteasqll
     1501 yflmrnnfdy tgkksfvrth lqviisvsql iadvvgiggt rfqqslsiin ncansdrlik
     1561 htsfssdvkd ltkrirtvlm ataqmkehen dpemlvdlqy slaksyastp elrktwldsm
     1621 arihvkngdl seaamcyvhv talvaeyltr kgvfrqgcta frvitpnide easmmedvgm
     1681 qdvhfnedvl melleqcadg lwkaeryeli adiykliipi yekrrdferl ahlydtlhra
     1741 yskvtevmhs grrllgtyfr vaffgqgffe dedgkeyiyk epkltplsei sqrllklysd
     1801 kfgsenvkmi qdsgkvnpkd ldskyayiqv thvipffdek elqerktefe rshnirrfmf
     1861 empftqtgkr qggveeqckr rtiltaihcf pyvkkripvm yqhhtdlnpi evaidemskk
     1921 vaelrqlcss aevdmiklql klqgsvsvqv nagplayara flddtntkry pdnkvkllke
     1981 vfrqfveacg qalavnerli kedqleyqee mkanyremak elseimheqi cpleektsvl
     2041 pnslhifnai sgtptstmvh gmtssssvv
//
LOCUS       XP_005254092            2062 aa            linear   PRI 05-AUG-2025
DEFINITION  dedicator of cytokinesis protein 9 isoform X27 [Homo sapiens].
ACCESSION   XP_005254092
VERSION     XP_005254092.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254035.4
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 4% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2062
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..2062
                     /product="dedicator of cytokinesis protein 9 isoform X27"
                     /calculated_mol_wt=235023
     Region          46..156
                     /region_name="DOCK_C-D_N"
                     /note="Dedicator of cytokinesis C/D, N terminal;
                     pfam11878"
                     /db_xref="CDD:463380"
     Region          170..293
                     /region_name="PH_DOCK-D"
                     /note="Dedicator of cytokinesis-D subfamily Pleckstrin
                     homology (PH) domain; cd13267"
                     /db_xref="CDD:270087"
     Region          639..828
                     /region_name="C2_Dock-D"
                     /note="C2 domains found in Dedicator Of CytoKinesis (Dock)
                     class C proteins; cd08697"
                     /db_xref="CDD:176079"
     Region          1604..2018
                     /region_name="DHR2_DOCK9"
                     /note="Dock Homology Region 2, a GEF domain, of Class D
                     Dedicator of Cytokinesis 9; cd11698"
                     /db_xref="CDD:212571"
     Site            order(1708,1718,1720..1721,1723..1724,1727..1728,
                     1730..1731,1734..1735)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            order(1742..1745,1747,1776..1777,1779..1782,1784..1785,
                     1804..1806,1823,1825,1854,1856,1863..1864,1870,1909..1910,
                     1913,1927,1929,1933,1936..1938,1941..1944,1946..1947,1950,
                     1978,1996..1997,1999..2000,2003)
                     /site_type="other"
                     /note="Cdc42 binding site [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            1941..1946
                     /site_type="other"
                     /note="nucleotide sensor"
                     /db_xref="CDD:212571"
     CDS             1..2062
                     /gene="DOCK9"
                     /gene_synonym="ZIZ1; ZIZIMIN1"
                     /coded_by="XM_005254035.4:344..6532"
                     /db_xref="GeneID:23348"
                     /db_xref="HGNC:HGNC:14132"
                     /db_xref="MIM:607325"
ORIGIN      
        1 msqppllpas aetrkftral skpgtaaelr qsvsevvrgs vllakpklie pldyenvivq
       61 kktqilndcl remllfpydd fqtailrrqg ryicstvpak aeeeaqslfv teciktynsd
      121 whlvnykyed ysgefrqlpn kvvkldklpv hvyevdeevd kdedaaslgs qkggitkhgw
      181 lykgnmnsai svtmrsfkrr ffhliqlgdg synlnfykde kiskepkgsi fldscmgvvq
      241 nnkvrrfafe lkmqdkssyl laadseveme ewitilnkil qlnfeaamqe krngdshedd
      301 eqsklegsgs gldsylpela ksareaeikl ksesrvklfy ldpdaqkldf ssaepevksf
      361 eekfgkrilv kcndlsfnlq ccvaeneegp ttnvepffvt lslfdikynr kisadfhvdl
      421 nhfsvrqmla ttspalmngs gqspsvlkgi lheaamqypk qgifsvtcph pdiflvarie
      481 kvlqgsithc aepymkssds skvaqkvlkn akqacqrlgq yrmpfawaar tlfkdasgnl
      541 dknarfsaiy rqdsnklsnd dmlklladfr kpekmaklpv ilgnlditid nvssdfpnyv
      601 nssyiptkqf etcsktpitf eveefvpcip khtqpytiyt nhlyvypkyl kydsqksfak
      661 arniaicief kdsdeedsqp lkciygrpgg pvftrsafaa vlhhhqnpef ydeikielpt
      721 qlhekhhlll tffhvscdns skgstkkrdv vetqvgyswl pllkdgrvvt seqhipvsan
      781 lpsgylgyqe lgmgrhygpe ikwvdggkpl lkisthlvst vytqdqhlhn ffqycqktes
      841 gaqalgnelv kylkslhame ghvmiaflpt ilnqlfrvlt ratqeevavn vtrviihvva
      901 qcheeglesh lrsyvkyayk aepyvaseyk tvheeltksm ttilkpsadf ltsnkllkys
      961 wfffdvliks maqhliensk vkllrnqrfp asyhhavetv vnmlmphitq kfrdnpeask
     1021 nanhslavfi krcftfmdrg fvfkqinnyi scfapgdpkt lfeykfeflr vvcnhehyip
     1081 lnlpmpfgkg riqryqdlql dysltdefcr nhflvglllr evgtalqefr evrliaisvl
     1141 knllikhsfd dryasrshqa riatlylplf gllienvqri nvrdvspfpv nagmtvkdes
     1201 lalpavnplv tpqkgstldn slhkdllgai sgiaspytts tpninsvrna dsrgslistd
     1261 sgnslperns eksnsldkhq qsstlgnsvv rcdkldqsei ksllmcflyi lksmsddalf
     1321 tywnkastse lmdfftisev clhqfqymgk ryiasvrkis svlgisvdng yghsdadvlh
     1381 qslleaniat evcltaldtl slftlafknq lladhghnpl mkkvfdvylc flqkhqseta
     1441 lknvftalrs liykfpstfy egradmcaal cyeilkccns klssirteas qllyflmrnn
     1501 fdytgkksfv rthlqviisv sqliadvvgi ggtrfqqsls iinncansdr likhtsfssd
     1561 vkdltkrirt vlmataqmke hendpemlvd lqyslaksya stpelrktwl dsmarihvkn
     1621 gdlseaamcy vhvtalvaey ltrkgvfrqg ctafrvitpn ideeasmmed vgmqdvhfne
     1681 dvlmelleqc adglwkaery eliadiykli ipiyekrrdf erlahlydtl hrayskvtev
     1741 mhsgrrllgt yfrvaffgqg ffededgkey iykepkltpl seisqrllkl ysdkfgsenv
     1801 kmiqdsgkvn pkdldskyay iqvthvipff dekelqerkt efershnirr fmfempftqt
     1861 gkrqggveeq ckrrtiltai hcfpyvkkri pvmyqhhtdl npievaidem skkvaelrql
     1921 cssaevdmik lqlklqgsvs vqvnagplay araflddtnt krypdnkvkl lkevfrqfve
     1981 acgqalavne rlikedqley qeemkanyre makelseimh eqicpleekt svlpnslhif
     2041 naisgtptst mvhgmtssss vv
//
LOCUS       XP_047286195            2058 aa            linear   PRI 05-AUG-2025
DEFINITION  dedicator of cytokinesis protein 9 isoform X28 [Homo sapiens].
ACCESSION   XP_047286195
VERSION     XP_047286195.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430239.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2058
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..2058
                     /product="dedicator of cytokinesis protein 9 isoform X28"
                     /calculated_mol_wt=234929
     Region          <1..84
                     /region_name="DOCK_C-D_N"
                     /note="Dedicator of cytokinesis C/D, N terminal;
                     pfam11878"
                     /db_xref="CDD:463380"
     Region          98..221
                     /region_name="PH_DOCK-D"
                     /note="Dedicator of cytokinesis-D subfamily Pleckstrin
                     homology (PH) domain; cd13267"
                     /db_xref="CDD:270087"
     Region          567..756
                     /region_name="C2_Dock-D"
                     /note="C2 domains found in Dedicator Of CytoKinesis (Dock)
                     class C proteins; cd08697"
                     /db_xref="CDD:176079"
     Region          1563..2014
                     /region_name="DHR2_DOCK9"
                     /note="Dock Homology Region 2, a GEF domain, of Class D
                     Dedicator of Cytokinesis 9; cd11698"
                     /db_xref="CDD:212571"
     Site            order(1690,1700,1702..1703,1705..1706,1709..1710,
                     1712..1713,1716..1717)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            order(1724..1727,1729,1772..1773,1775..1778,1780..1781,
                     1800..1802,1819,1821,1850,1852,1859..1860,1866,1905..1906,
                     1909,1923,1925,1929,1932..1934,1937..1940,1942..1943,1946,
                     1974,1992..1993,1995..1996,1999)
                     /site_type="other"
                     /note="Cdc42 binding site [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            1937..1942
                     /site_type="other"
                     /note="nucleotide sensor"
                     /db_xref="CDD:212571"
     CDS             1..2058
                     /gene="DOCK9"
                     /gene_synonym="ZIZ1; ZIZIMIN1"
                     /coded_by="XM_047430239.1:353..6529"
                     /db_xref="GeneID:23348"
                     /db_xref="HGNC:HGNC:14132"
                     /db_xref="MIM:607325"
ORIGIN      
        1 mllfpyddfq tailrrqgry icstvpakae eeaqslfvte ciktynsdwh lvnykyedys
       61 gefrqlpnkv vkldklpvhv yevdeevdkd edaaslgsqk ggitkhgwly kgnmnsaisv
      121 tmrsfkrrff hliqlgdgsy nlnfykdeki skepkgsifl dscmgvvqnn kvrrfafelk
      181 mqdkssylla adsevemeew itilnkilql nfeaamqekr ngdsheddeq sklegsgsgl
      241 dsylpelaks areaeiklks esrvklfyld pdaqkldfss aepevksfee kfgkrilvkc
      301 ndlsfnlqcc vaeneegptt nvepffvtls lfdikynrki sadfhvdlnh fsvrqmlatt
      361 spalmngsgq spsvlkgilh eaamqypkqg ifsvtcphpd iflvariekv lqgsithcae
      421 pymkssdssk vaqkvlknak qacqrlgqyr mpfawaartl fkdasgnldk narfsaiyrq
      481 dsnklsnddm lklladfrkp ekmaklpvil gnlditidnv ssdfpnyvns syiptkqfet
      541 csktpitfev eefvpcipkh tqpytiytnh lyvypkylky dsqksfakar niaiciefkd
      601 sdeedsqplk ciygrpggpv ftrsafaavl hhhqnpefyd eikielptql hekhhllltf
      661 fhvscdnssk gstkkrdvve tqvgyswlpl lkdgrvvtse qhipvsanlp sgylgyqelg
      721 mgrhygpeik wvdggkpllk isthlvstvy tqdqhlhnff qycqktesga qalgnelvky
      781 lkslhamegh vmiaflptil nqlfrvltra tqeevavnvt rviihvvaqc heegleshlr
      841 syvkyaykae pyvaseyktv heeltksmtt ilkpsadflt snkllkyswf ffdvliksma
      901 qhlienskvk llrnqrfpas yhhavetvvn mlmphitqkf rdnpeaskna nhslavfikr
      961 cftfmdrgfv fkqinnyisc fapgdpktlf eykfeflrvv cnhehyipln lpmpfgkgri
     1021 qryqdlqldy sltdefcrnh flvglllrev gtalqefrev rliaisvlkn llikhsfddr
     1081 yasrshqari atlylplfgl lienvqrinv rdvspfpvna gmtvkdesla lpavnplvtp
     1141 qkgstldnsl hkdllgaisg iaspyttstp ninsvrnads rgslistdsg nslpernsek
     1201 snsldkhqqs stlgnsvvrc dkldqseiks llmcflyilk smsddalfty wnkastselm
     1261 dfftisevcl hqfqymgkry iarnqeglgp ivhdrksqtl pvsrnrtgmm harlqqlgsl
     1321 dnsltfnhsy ghsdadvlhq slleaniate vcltaldtls lftlafknql ladhghnplm
     1381 kkvfdvylcf lqkhqsetal knvftalrsl iykfpstfye gradmcaalc yeilkccnsk
     1441 lssirteasq llyflmrnnf dytgkksfvr thlqviisvs qliadvvgig gtrfqqslsi
     1501 inncansdrl ikhtsfssdv kdltkrirtv lmataqmkeh endpemlvdl qyslaksyas
     1561 tpelrktwld smarihvkng dlseaamcyv hvtalvaeyl trkeavqwep pllphshsac
     1621 lrrsrggvfr qgctafrvit pnideeasmm edvgmqdvhf nedvlmelle qcadglwkae
     1681 ryeliadiyk liipiyekrr dferlahlyd tlhrayskvt evmhsgrrll gtyfrvaffg
     1741 qaaqyqftds etdvegffed edgkeyiyke pkltplseis qrllklysdk fgsenvkmiq
     1801 dsgkvnpkdl dskyayiqvt hvipffdeke lqerktefer shnirrfmfe mpftqtgkrq
     1861 ggveeqckrr tiltaihcfp yvkkripvmy qhhtdlnpie vaidemskkv aelrqlcssa
     1921 evdmiklqlk lqgsvsvqvn agplayaraf lddtntkryp dnkvkllkev frqfveacgq
     1981 alavnerlik edqleyqeem kanyremake lseimheqic pleektsvlp nslhifnais
     2041 gtptstmvhg mtssssvv
//
LOCUS       XP_047286196            2021 aa            linear   PRI 05-AUG-2025
DEFINITION  dedicator of cytokinesis protein 9 isoform X29 [Homo sapiens].
ACCESSION   XP_047286196
VERSION     XP_047286196.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430240.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2021
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..2021
                     /product="dedicator of cytokinesis protein 9 isoform X29"
                     /calculated_mol_wt=230734
     Region          <1..84
                     /region_name="DOCK_C-D_N"
                     /note="Dedicator of cytokinesis C/D, N terminal;
                     pfam11878"
                     /db_xref="CDD:463380"
     Region          98..221
                     /region_name="PH_DOCK-D"
                     /note="Dedicator of cytokinesis-D subfamily Pleckstrin
                     homology (PH) domain; cd13267"
                     /db_xref="CDD:270087"
     Region          567..756
                     /region_name="C2_Dock-D"
                     /note="C2 domains found in Dedicator Of CytoKinesis (Dock)
                     class C proteins; cd08697"
                     /db_xref="CDD:176079"
     Region          1563..1977
                     /region_name="DHR2_DOCK9"
                     /note="Dock Homology Region 2, a GEF domain, of Class D
                     Dedicator of Cytokinesis 9; cd11698"
                     /db_xref="CDD:212571"
     Site            order(1667,1677,1679..1680,1682..1683,1686..1687,
                     1689..1690,1693..1694)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            order(1701..1704,1706,1735..1736,1738..1741,1743..1744,
                     1763..1765,1782,1784,1813,1815,1822..1823,1829,1868..1869,
                     1872,1886,1888,1892,1895..1897,1900..1903,1905..1906,1909,
                     1937,1955..1956,1958..1959,1962)
                     /site_type="other"
                     /note="Cdc42 binding site [polypeptide binding]"
                     /db_xref="CDD:212571"
     Site            1900..1905
                     /site_type="other"
                     /note="nucleotide sensor"
                     /db_xref="CDD:212571"
     CDS             1..2021
                     /gene="DOCK9"
                     /gene_synonym="ZIZ1; ZIZIMIN1"
                     /coded_by="XM_047430240.1:353..6418"
                     /db_xref="GeneID:23348"
                     /db_xref="HGNC:HGNC:14132"
                     /db_xref="MIM:607325"
ORIGIN      
        1 mllfpyddfq tailrrqgry icstvpakae eeaqslfvte ciktynsdwh lvnykyedys
       61 gefrqlpnkv vkldklpvhv yevdeevdkd edaaslgsqk ggitkhgwly kgnmnsaisv
      121 tmrsfkrrff hliqlgdgsy nlnfykdeki skepkgsifl dscmgvvqnn kvrrfafelk
      181 mqdkssylla adsevemeew itilnkilql nfeaamqekr ngdsheddeq sklegsgsgl
      241 dsylpelaks areaeiklks esrvklfyld pdaqkldfss aepevksfee kfgkrilvkc
      301 ndlsfnlqcc vaeneegptt nvepffvtls lfdikynrki sadfhvdlnh fsvrqmlatt
      361 spalmngsgq spsvlkgilh eaamqypkqg ifsvtcphpd iflvariekv lqgsithcae
      421 pymkssdssk vaqkvlknak qacqrlgqyr mpfawaartl fkdasgnldk narfsaiyrq
      481 dsnklsnddm lklladfrkp ekmaklpvil gnlditidnv ssdfpnyvns syiptkqfet
      541 csktpitfev eefvpcipkh tqpytiytnh lyvypkylky dsqksfakar niaiciefkd
      601 sdeedsqplk ciygrpggpv ftrsafaavl hhhqnpefyd eikielptql hekhhllltf
      661 fhvscdnssk gstkkrdvve tqvgyswlpl lkdgrvvtse qhipvsanlp sgylgyqelg
      721 mgrhygpeik wvdggkpllk isthlvstvy tqdqhlhnff qycqktesga qalgnelvky
      781 lkslhamegh vmiaflptil nqlfrvltra tqeevavnvt rviihvvaqc heegleshlr
      841 syvkyaykae pyvaseyktv heeltksmtt ilkpsadflt snkllkyswf ffdvliksma
      901 qhlienskvk llrnqrfpas yhhavetvvn mlmphitqkf rdnpeaskna nhslavfikr
      961 cftfmdrgfv fkqinnyisc fapgdpktlf eykfeflrvv cnhehyipln lpmpfgkgri
     1021 qryqdlqldy sltdefcrnh flvglllrev gtalqefrev rliaisvlkn llikhsfddr
     1081 yasrshqari atlylplfgl lienvqrinv rdvspfpvna gmtvkdesla lpavnplvtp
     1141 qkgstldnsl hkdllgaisg iaspyttstp ninsvrnads rgslistdsg nslpernsek
     1201 snsldkhqqs stlgnsvvrc dkldqseiks llmcflyilk smsddalfty wnkastselm
     1261 dfftisevcl hqfqymgkry iarnqeglgp ivhdrksqtl pvsrnrtgmm harlqqlgsl
     1321 dnsltfnhsy ghsdadvlhq slleaniate vcltaldtls lftlafknql ladhghnplm
     1381 kkvfdvylcf lqkhqsetal knvftalrsl iykfpstfye gradmcaalc yeilkccnsk
     1441 lssirteasq llyflmrnnf dytgkksfvr thlqviisvs qliadvvgig gtrfqqslsi
     1501 inncansdrl ikhtsfssdv kdltkrirtv lmataqmkeh endpemlvdl qyslaksyas
     1561 tpelrktwld smarihvkng dlseaamcyv hvtalvaeyl trkgvfrqgc tafrvitpni
     1621 deeasmmedv gmqdvhfned vlmelleqca dglwkaerye liadiyklii piyekrrdfe
     1681 rlahlydtlh rayskvtevm hsgrrllgty frvaffgqgf fededgkeyi ykepkltpls
     1741 eisqrllkly sdkfgsenvk miqdsgkvnp kdldskyayi qvthvipffd ekelqerkte
     1801 fershnirrf mfempftqtg krqggveeqc krrtiltaih cfpyvkkrip vmyqhhtdln
     1861 pievaidems kkvaelrqlc ssaevdmikl qlklqgsvsv qvnagplaya raflddtntk
     1921 rypdnkvkll kevfrqfvea cgqalavner likedqleyq eemkanyrem akelseimhe
     1981 qicpleekts vlpnslhifn aisgtptstm vhgmtssssv v
//
LOCUS       XP_016876011             121 aa            linear   PRI 05-AUG-2025
DEFINITION  arachidonate 5-lipoxygenase-activating protein isoform X1 [Homo
            sapiens].
ACCESSION   XP_016876011
VERSION     XP_016876011.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020522.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..121
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..121
                     /product="arachidonate 5-lipoxygenase-activating protein
                     isoform X1"
                     /calculated_mol_wt=13743
     Region          <18..88
                     /region_name="MAPEG"
                     /note="MAPEG family; pfam01124"
                     /db_xref="CDD:460074"
     CDS             1..121
                     /gene="ALOX5AP"
                     /gene_synonym="FLAP"
                     /coded_by="XM_017020522.3:227..592"
                     /db_xref="GeneID:241"
                     /db_xref="HGNC:HGNC:436"
                     /db_xref="MIM:603700"
ORIGIN      
        1 mrlqeeknmh lillsenqnc vdayptflav lwsagllcsq vpaafaglmy lfvrqkyfvg
       61 ylgertqstp gyifgkriil flflmsvagi fnyylifffg sdfenyikti sttispllli
      121 p
//
LOCUS       XP_005266378             293 aa            linear   PRI 05-AUG-2025
DEFINITION  kidney mitochondrial carrier protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_005266378
VERSION     XP_005266378.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266321.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..293
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..293
                     /product="kidney mitochondrial carrier protein 1 isoform
                     X1"
                     /calculated_mol_wt=31856
     Region          5..100
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     Region          102..191
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     Region          199..>252
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     CDS             1..293
                     /gene="SLC25A30"
                     /gene_synonym="KMCP1"
                     /coded_by="XM_005266321.3:130..1011"
                     /db_xref="GeneID:253512"
                     /db_xref="HGNC:HGNC:27371"
                     /db_xref="MIM:610793"
ORIGIN      
        1 msalnwkpfv ygglasitae cgtfpidltk trlqiqgqtn dakfkeiryr gmlhalvrig
       61 reeglkalys giapamlrqa sygtikigty qslkrlfier pedetlpinv icgilsgvis
      121 stianptdvl kirmqaqsnt iqggmignfm niyqqegtrg lwkgvsltaq raaivvgvel
      181 pvyditkkhl ilsglmgdtv ythflssftc glagalasnp vdvvrtrmmn qrvlrdgrcs
      241 gytgtldcll qltvlesfst takpqklisv daiseeadtr gftylscdls aps
//
LOCUS       XP_006719856             293 aa            linear   PRI 05-AUG-2025
DEFINITION  kidney mitochondrial carrier protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_006719856
VERSION     XP_006719856.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006719793.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..293
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..293
                     /product="kidney mitochondrial carrier protein 1 isoform
                     X1"
                     /calculated_mol_wt=31856
     Region          5..100
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     Region          102..191
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     Region          199..>252
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     CDS             1..293
                     /gene="SLC25A30"
                     /gene_synonym="KMCP1"
                     /coded_by="XM_006719793.5:199..1080"
                     /db_xref="GeneID:253512"
                     /db_xref="HGNC:HGNC:27371"
                     /db_xref="MIM:610793"
ORIGIN      
        1 msalnwkpfv ygglasitae cgtfpidltk trlqiqgqtn dakfkeiryr gmlhalvrig
       61 reeglkalys giapamlrqa sygtikigty qslkrlfier pedetlpinv icgilsgvis
      121 stianptdvl kirmqaqsnt iqggmignfm niyqqegtrg lwkgvsltaq raaivvgvel
      181 pvyditkkhl ilsglmgdtv ythflssftc glagalasnp vdvvrtrmmn qrvlrdgrcs
      241 gytgtldcll qltvlesfst takpqklisv daiseeadtr gftylscdls aps
//
LOCUS       XP_006719857             293 aa            linear   PRI 05-AUG-2025
DEFINITION  kidney mitochondrial carrier protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_006719857
VERSION     XP_006719857.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006719794.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..293
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..293
                     /product="kidney mitochondrial carrier protein 1 isoform
                     X1"
                     /calculated_mol_wt=31856
     Region          5..100
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     Region          102..191
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     Region          199..>252
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     CDS             1..293
                     /gene="SLC25A30"
                     /gene_synonym="KMCP1"
                     /coded_by="XM_006719794.3:262..1143"
                     /db_xref="GeneID:253512"
                     /db_xref="HGNC:HGNC:27371"
                     /db_xref="MIM:610793"
ORIGIN      
        1 msalnwkpfv ygglasitae cgtfpidltk trlqiqgqtn dakfkeiryr gmlhalvrig
       61 reeglkalys giapamlrqa sygtikigty qslkrlfier pedetlpinv icgilsgvis
      121 stianptdvl kirmqaqsnt iqggmignfm niyqqegtrg lwkgvsltaq raaivvgvel
      181 pvyditkkhl ilsglmgdtv ythflssftc glagalasnp vdvvrtrmmn qrvlrdgrcs
      241 gytgtldcll qltvlesfst takpqklisv daiseeadtr gftylscdls aps
//
LOCUS       XP_016876012             293 aa            linear   PRI 05-AUG-2025
DEFINITION  kidney mitochondrial carrier protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_016876012
VERSION     XP_016876012.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020523.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..293
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..293
                     /product="kidney mitochondrial carrier protein 1 isoform
                     X1"
                     /calculated_mol_wt=31856
     Region          5..100
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     Region          102..191
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     Region          199..>252
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     CDS             1..293
                     /gene="SLC25A30"
                     /gene_synonym="KMCP1"
                     /coded_by="XM_017020523.2:209..1090"
                     /db_xref="GeneID:253512"
                     /db_xref="HGNC:HGNC:27371"
                     /db_xref="MIM:610793"
ORIGIN      
        1 msalnwkpfv ygglasitae cgtfpidltk trlqiqgqtn dakfkeiryr gmlhalvrig
       61 reeglkalys giapamlrqa sygtikigty qslkrlfier pedetlpinv icgilsgvis
      121 stianptdvl kirmqaqsnt iqggmignfm niyqqegtrg lwkgvsltaq raaivvgvel
      181 pvyditkkhl ilsglmgdtv ythflssftc glagalasnp vdvvrtrmmn qrvlrdgrcs
      241 gytgtldcll qltvlesfst takpqklisv daiseeadtr gftylscdls aps
//
LOCUS       XP_047286197             291 aa            linear   PRI 05-AUG-2025
DEFINITION  kidney mitochondrial carrier protein 1 isoform X2 [Homo sapiens].
ACCESSION   XP_047286197
VERSION     XP_047286197.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430241.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..291
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..291
                     /product="kidney mitochondrial carrier protein 1 isoform
                     X2"
                     /calculated_mol_wt=32344
     Region          9..289
                     /region_name="PTZ00169"
                     /note="ADP/ATP transporter on adenylate translocase;
                     Provisional"
                     /db_xref="CDD:240302"
     CDS             1..291
                     /gene="SLC25A30"
                     /gene_synonym="KMCP1"
                     /coded_by="XM_047430241.1:199..1074"
                     /db_xref="GeneID:253512"
                     /db_xref="HGNC:HGNC:27371"
                     /db_xref="MIM:610793"
ORIGIN      
        1 msalnwkpfv ygglasitae cgtfpidltk trlqiqgqtn dakfkeiryr gmlhalvrig
       61 reeglkalys giapamlrqa sygtikigty qslkrlfier pedetlpinv icgilsgvis
      121 stianptdvl kirmqaqsnt iqggmignfm niyqqegtrg lwkgvsltaq raaivvgvel
      181 pvyditkkhl ilsglmgdtv ythflssftc glagalasnp vdvvrtrmmn qrvlrdgrcs
      241 gytgtldcll qtwknegffa lykgfwpnwl rlgpwniiff vtyeqlkkld l
//
LOCUS       XP_016876013             291 aa            linear   PRI 05-AUG-2025
DEFINITION  kidney mitochondrial carrier protein 1 isoform X2 [Homo sapiens].
ACCESSION   XP_016876013
VERSION     XP_016876013.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020524.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..291
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..291
                     /product="kidney mitochondrial carrier protein 1 isoform
                     X2"
                     /calculated_mol_wt=32344
     Region          9..289
                     /region_name="PTZ00169"
                     /note="ADP/ATP transporter on adenylate translocase;
                     Provisional"
                     /db_xref="CDD:240302"
     CDS             1..291
                     /gene="SLC25A30"
                     /gene_synonym="KMCP1"
                     /coded_by="XM_017020524.3:262..1137"
                     /db_xref="GeneID:253512"
                     /db_xref="HGNC:HGNC:27371"
                     /db_xref="MIM:610793"
ORIGIN      
        1 msalnwkpfv ygglasitae cgtfpidltk trlqiqgqtn dakfkeiryr gmlhalvrig
       61 reeglkalys giapamlrqa sygtikigty qslkrlfier pedetlpinv icgilsgvis
      121 stianptdvl kirmqaqsnt iqggmignfm niyqqegtrg lwkgvsltaq raaivvgvel
      181 pvyditkkhl ilsglmgdtv ythflssftc glagalasnp vdvvrtrmmn qrvlrdgrcs
      241 gytgtldcll qtwknegffa lykgfwpnwl rlgpwniiff vtyeqlkkld l
//
LOCUS       XP_005266379             254 aa            linear   PRI 05-AUG-2025
DEFINITION  kidney mitochondrial carrier protein 1 isoform X3 [Homo sapiens].
ACCESSION   XP_005266379
VERSION     XP_005266379.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266322.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..254
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..254
                     /product="kidney mitochondrial carrier protein 1 isoform
                     X3"
                     /calculated_mol_wt=27690
     Region          5..100
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     Region          102..191
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     Region          199..>253
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     CDS             1..254
                     /gene="SLC25A30"
                     /gene_synonym="KMCP1"
                     /coded_by="XM_005266322.2:130..894"
                     /db_xref="GeneID:253512"
                     /db_xref="HGNC:HGNC:27371"
                     /db_xref="MIM:610793"
ORIGIN      
        1 msalnwkpfv ygglasitae cgtfpidltk trlqiqgqtn dakfkeiryr gmlhalvrig
       61 reeglkalys giapamlrqa sygtikigty qslkrlfier pedetlpinv icgilsgvis
      121 stianptdvl kirmqaqsnt iqggmignfm niyqqegtrg lwkgvsltaq raaivvgvel
      181 pvyditkkhl ilsglmgdtv ythflssftc glagalasnp vdvvrtrmmn qrvlrdgrcs
      241 gytgtldcll qvlp
//
LOCUS       XP_006719859             364 aa            linear   PRI 05-AUG-2025
DEFINITION  palmitoyltransferase ZDHHC20 isoform X1 [Homo sapiens].
ACCESSION   XP_006719859
VERSION     XP_006719859.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006719796.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..364
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..364
                     /product="palmitoyltransferase ZDHHC20 isoform X1"
                     /calculated_mol_wt=42060
     Region          16..301
                     /region_name="DHHC"
                     /note="DHHC palmitoyltransferase; cl19890"
                     /db_xref="CDD:418707"
     CDS             1..364
                     /gene="ZDHHC20"
                     /gene_synonym="4933421L13Rik; DHHC-20; DHHC20"
                     /coded_by="XM_006719796.2:133..1227"
                     /db_xref="GeneID:253832"
                     /db_xref="HGNC:HGNC:20749"
                     /db_xref="MIM:617972"
ORIGIN      
        1 mapwtlwrcc qrvvgwvpvl fitfvvvwsy yayvvelcvf tifgneengk tvvylvafhl
       61 ffvmfvwsyw mtiftspasp skefylsnse keryekefsq erqqeilrra aralpiytts
      121 asktirycek cqlikpdrah hcsacdscil kmdhhcpwvn ncvgfsnykf fllfllysll
      181 yclfvaatvl eyfikfwtne ltdtrakfhv lflffvsamf fisvlslfsy hcwlvgknrt
      241 tiesfraptf sygpdgngfs lgcsknwrqv fgdekkywll pifsslgdgc sfptrlvgmd
      301 peqasvtnqn eyarsgsnqp fpikplsesk nrlldsesqw lengaeegiv ksgtnnhvtv
      361 aien
//
LOCUS       XP_006719860             355 aa            linear   PRI 05-AUG-2025
DEFINITION  palmitoyltransferase ZDHHC20 isoform X2 [Homo sapiens].
ACCESSION   XP_006719860
VERSION     XP_006719860.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006719797.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..355
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..355
                     /product="palmitoyltransferase ZDHHC20 isoform X2"
                     /calculated_mol_wt=41052
     Region          16..301
                     /region_name="DHHC"
                     /note="DHHC palmitoyltransferase; cl19890"
                     /db_xref="CDD:418707"
     CDS             1..355
                     /gene="ZDHHC20"
                     /gene_synonym="4933421L13Rik; DHHC-20; DHHC20"
                     /coded_by="XM_006719797.2:133..1200"
                     /db_xref="GeneID:253832"
                     /db_xref="HGNC:HGNC:20749"
                     /db_xref="MIM:617972"
ORIGIN      
        1 mapwtlwrcc qrvvgwvpvl fitfvvvwsy yayvvelcvf tifgneengk tvvylvafhl
       61 ffvmfvwsyw mtiftspasp skefylsnse keryekefsq erqqeilrra aralpiytts
      121 asktirycek cqlikpdrah hcsacdscil kmdhhcpwvn ncvgfsnykf fllfllysll
      181 yclfvaatvl eyfikfwtne ltdtrakfhv lflffvsamf fisvlslfsy hcwlvgknrt
      241 tiesfraptf sygpdgngfs lgcsknwrqv fgdekkywll pifsslgdgc sfptrlvgmd
      301 peqasvtnqn eyarssgsnq pfpikplses knrlldsesq wlengaeegi vksgv
//
LOCUS       XP_047286198             320 aa            linear   PRI 05-AUG-2025
DEFINITION  palmitoyltransferase ZDHHC20 isoform X3 [Homo sapiens].
ACCESSION   XP_047286198
VERSION     XP_047286198.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430242.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..320
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..320
                     /product="palmitoyltransferase ZDHHC20 isoform X3"
                     /calculated_mol_wt=37424
     Region          16..301
                     /region_name="DHHC"
                     /note="DHHC palmitoyltransferase; cl19890"
                     /db_xref="CDD:418707"
     CDS             1..320
                     /gene="ZDHHC20"
                     /gene_synonym="4933421L13Rik; DHHC-20; DHHC20"
                     /coded_by="XM_047430242.1:133..1095"
                     /db_xref="GeneID:253832"
                     /db_xref="HGNC:HGNC:20749"
                     /db_xref="MIM:617972"
ORIGIN      
        1 mapwtlwrcc qrvvgwvpvl fitfvvvwsy yayvvelcvf tifgneengk tvvylvafhl
       61 ffvmfvwsyw mtiftspasp skefylsnse keryekefsq erqqeilrra aralpiytts
      121 asktirycek cqlikpdrah hcsacdscil kmdhhcpwvn ncvgfsnykf fllfllysll
      181 yclfvaatvl eyfikfwtne ltdtrakfhv lflffvsamf fisvlslfsy hcwlvgknrt
      241 tiesfraptf sygpdgngfs lgcsknwrqv fgdekkywll pifsslgdgc sfptrlvgmd
      301 peqasvtnqn eyarrsklqr
//
LOCUS       XP_047286199             302 aa            linear   PRI 05-AUG-2025
DEFINITION  palmitoyltransferase ZDHHC20 isoform X4 [Homo sapiens].
ACCESSION   XP_047286199
VERSION     XP_047286199.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430243.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..302
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..302
                     /product="palmitoyltransferase ZDHHC20 isoform X4"
                     /calculated_mol_wt=34707
     Region          <52..238
                     /region_name="DHHC"
                     /note="DHHC palmitoyltransferase; cl19890"
                     /db_xref="CDD:418707"
     CDS             1..302
                     /gene="ZDHHC20"
                     /gene_synonym="4933421L13Rik; DHHC-20; DHHC20"
                     /coded_by="XM_047430243.1:365..1273"
                     /db_xref="GeneID:253832"
                     /db_xref="HGNC:HGNC:20749"
                     /db_xref="MIM:617972"
ORIGIN      
        1 mfvwsywmti ftspaspske fylsnseker yekefsqerq qeilrraara lpiyttsask
       61 tirycekcql ikpdrahhcs acdscilkmd hhcpwvnncv gfsnykffll fllysllycl
      121 fvaatvleyf ikfwtneltd trakfhvlfl ffvsamffis vlslfsyhcw lvgknrttie
      181 sfraptfsyg pdgngfslgc sknwrqvfgd ekkywllpif sslgdgcsfp trlvgmdpeq
      241 asvtnqneya rssgsnqpfp ikplsesknr lldsesqwle ngaeegivks gtnnhvtvai
      301 en
//
LOCUS       XP_016876014             294 aa            linear   PRI 05-AUG-2025
DEFINITION  palmitoyltransferase ZDHHC20 isoform X5 [Homo sapiens].
ACCESSION   XP_016876014
VERSION     XP_016876014.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020525.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..294
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..294
                     /product="palmitoyltransferase ZDHHC20 isoform X5"
                     /calculated_mol_wt=33823
     Region          <44..230
                     /region_name="DHHC"
                     /note="DHHC palmitoyltransferase; cl19890"
                     /db_xref="CDD:418707"
     CDS             1..294
                     /gene="ZDHHC20"
                     /gene_synonym="4933421L13Rik; DHHC-20; DHHC20"
                     /coded_by="XM_017020525.2:149..1033"
                     /db_xref="GeneID:253832"
                     /db_xref="HGNC:HGNC:20749"
                     /db_xref="MIM:617972"
ORIGIN      
        1 mlhlpcqrty hlfylsnsek eryekefsqe rqqeilrraa ralpiyttsa sktirycekc
       61 qlikpdrahh csacdscilk mdhhcpwvnn cvgfsnykff llfllyslly clfvaatvle
      121 yfikfwtnel tdtrakfhvl flffvsamff isvlslfsyh cwlvgknrtt iesfraptfs
      181 ygpdgngfsl gcsknwrqvf gdekkywllp ifsslgdgcs fptrlvgmdp eqasvtnqne
      241 yarssgsnqp fpikplsesk nrlldsesqw lengaeegiv ksgtnnhvtv aien
//
LOCUS       XP_047286200             292 aa            linear   PRI 05-AUG-2025
DEFINITION  palmitoyltransferase ZDHHC20 isoform X6 [Homo sapiens].
ACCESSION   XP_047286200
VERSION     XP_047286200.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430244.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..292
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..292
                     /product="palmitoyltransferase ZDHHC20 isoform X6"
                     /calculated_mol_wt=33613
     Region          <52..238
                     /region_name="DHHC"
                     /note="DHHC palmitoyltransferase; cl19890"
                     /db_xref="CDD:418707"
     CDS             1..292
                     /gene="ZDHHC20"
                     /gene_synonym="4933421L13Rik; DHHC-20; DHHC20"
                     /coded_by="XM_047430244.1:365..1243"
                     /db_xref="GeneID:253832"
                     /db_xref="HGNC:HGNC:20749"
                     /db_xref="MIM:617972"
ORIGIN      
        1 mfvwsywmti ftspaspske fylsnseker yekefsqerq qeilrraara lpiyttsask
       61 tirycekcql ikpdrahhcs acdscilkmd hhcpwvnncv gfsnykffll fllysllycl
      121 fvaatvleyf ikfwtneltd trakfhvlfl ffvsamffis vlslfsyhcw lvgknrttie
      181 sfraptfsyg pdgngfslgc sknwrqvfgd ekkywllpif sslgdgcsfp trlvgmdpeq
      241 asvtnqneya rssgsnqpfp ikplsesknr lldsesqwle ngaeegivks gv
//
LOCUS       XP_047286201             291 aa            linear   PRI 05-AUG-2025
DEFINITION  palmitoyltransferase ZDHHC20 isoform X7 [Homo sapiens].
ACCESSION   XP_047286201
VERSION     XP_047286201.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430245.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..291
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..291
                     /product="palmitoyltransferase ZDHHC20 isoform X7"
                     /calculated_mol_wt=33525
     Region          <52..238
                     /region_name="DHHC"
                     /note="DHHC palmitoyltransferase; cl19890"
                     /db_xref="CDD:418707"
     CDS             1..291
                     /gene="ZDHHC20"
                     /gene_synonym="4933421L13Rik; DHHC-20; DHHC20"
                     /coded_by="XM_047430245.1:365..1240"
                     /db_xref="GeneID:253832"
                     /db_xref="HGNC:HGNC:20749"
                     /db_xref="MIM:617972"
ORIGIN      
        1 mfvwsywmti ftspaspske fylsnseker yekefsqerq qeilrraara lpiyttsask
       61 tirycekcql ikpdrahhcs acdscilkmd hhcpwvnncv gfsnykffll fllysllycl
      121 fvaatvleyf ikfwtneltd trakfhvlfl ffvsamffis vlslfsyhcw lvgknrttie
      181 sfraptfsyg pdgngfslgc sknwrqvfgd ekkywllpif sslgdgcsfp trlvgmdpeq
      241 asvtnqneya rsgsnqpfpi kplsesknrl ldsesqwlen gaeegivksg v
//
LOCUS       XP_047286202             286 aa            linear   PRI 05-AUG-2025
DEFINITION  palmitoyltransferase ZDHHC20 isoform X8 [Homo sapiens].
ACCESSION   XP_047286202
VERSION     XP_047286202.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430246.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 24% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..286
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..286
                     /product="palmitoyltransferase ZDHHC20 isoform X8"
                     /calculated_mol_wt=32848
     Region          <36..222
                     /region_name="DHHC"
                     /note="DHHC palmitoyltransferase; cl19890"
                     /db_xref="CDD:418707"
     CDS             1..286
                     /gene="ZDHHC20"
                     /gene_synonym="4933421L13Rik; DHHC-20; DHHC20"
                     /coded_by="XM_047430246.1:309..1169"
                     /db_xref="GeneID:253832"
                     /db_xref="HGNC:HGNC:20749"
                     /db_xref="MIM:617972"
ORIGIN      
        1 mkkmfylsns ekeryekefs qerqqeilrr aaralpiytt sasktiryce kcqlikpdra
       61 hhcsacdsci lkmdhhcpwv nncvgfsnyk ffllfllysl lyclfvaatv leyfikfwtn
      121 eltdtrakfh vlflffvsam ffisvlslfs yhcwlvgknr ttiesfrapt fsygpdgngf
      181 slgcsknwrq vfgdekkywl lpifsslgdg csfptrlvgm dpeqasvtnq neyarssgsn
      241 qpfpikplse sknrlldses qwlengaeeg ivksgtnnhv tvaien
//
LOCUS       XP_011533332             217 aa            linear   PRI 05-AUG-2025
DEFINITION  palmitoyltransferase ZDHHC20 isoform X9 [Homo sapiens].
ACCESSION   XP_011533332
VERSION     XP_011533332.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535030.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..217
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..217
                     /product="palmitoyltransferase ZDHHC20 isoform X9"
                     /calculated_mol_wt=24570
     Region          <58..153
                     /region_name="DHHC"
                     /note="DHHC palmitoyltransferase; cl19890"
                     /db_xref="CDD:418707"
     CDS             1..217
                     /gene="ZDHHC20"
                     /gene_synonym="4933421L13Rik; DHHC-20; DHHC20"
                     /coded_by="XM_011535030.4:67..720"
                     /db_xref="GeneID:253832"
                     /db_xref="HGNC:HGNC:20749"
                     /db_xref="MIM:617972"
ORIGIN      
        1 mairkqhlsv lstgfiklvf riilhknwfl niclylhklc rrkstescpk neltdtrakf
       61 hvlflffvsa mffisvlslf syhcwlvgkn rttiesfrap tfsygpdgng fslgcsknwr
      121 qvfgdekkyw llpifsslgd gcsfptrlvg mdpeqasvtn qneyarssgs nqpfpikpls
      181 esknrlldse sqwlengaee givksgtnnh vtvaien
//
LOCUS       XP_047286203             214 aa            linear   PRI 05-AUG-2025
DEFINITION  palmitoyltransferase ZDHHC20 isoform X10 [Homo sapiens].
ACCESSION   XP_047286203
VERSION     XP_047286203.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430247.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..214
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..214
                     /product="palmitoyltransferase ZDHHC20 isoform X10"
                     /calculated_mol_wt=24304
     Region          <1..150
                     /region_name="DHHC"
                     /note="DHHC palmitoyltransferase; cl19890"
                     /db_xref="CDD:418707"
     CDS             1..214
                     /gene="ZDHHC20"
                     /gene_synonym="4933421L13Rik; DHHC-20; DHHC20"
                     /coded_by="XM_047430247.1:615..1259"
                     /db_xref="GeneID:253832"
                     /db_xref="HGNC:HGNC:20749"
                     /db_xref="MIM:617972"
ORIGIN      
        1 mdhhcpwvnn cvgfsnykff llfllyslly clfvaatvle yfikfwtnel tdtrakfhvl
       61 flffvsamff isvlslfsyh cwlvgknrtt iesfraptfs ygpdgngfsl gcsknwrqvf
      121 gdekkywllp ifsslgdgcs fptrlvgmdp eqasvtnqne yarssgsnqp fpikplsesk
      181 nrlldsesqw lengaeegiv ksgtnnhvtv aien
//
LOCUS       XP_047286204             214 aa            linear   PRI 05-AUG-2025
DEFINITION  palmitoyltransferase ZDHHC20 isoform X10 [Homo sapiens].
ACCESSION   XP_047286204
VERSION     XP_047286204.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430248.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..214
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..214
                     /product="palmitoyltransferase ZDHHC20 isoform X10"
                     /calculated_mol_wt=24304
     Region          <1..150
                     /region_name="DHHC"
                     /note="DHHC palmitoyltransferase; cl19890"
                     /db_xref="CDD:418707"
     CDS             1..214
                     /gene="ZDHHC20"
                     /gene_synonym="4933421L13Rik; DHHC-20; DHHC20"
                     /coded_by="XM_047430248.1:174..818"
                     /db_xref="GeneID:253832"
                     /db_xref="HGNC:HGNC:20749"
                     /db_xref="MIM:617972"
ORIGIN      
        1 mdhhcpwvnn cvgfsnykff llfllyslly clfvaatvle yfikfwtnel tdtrakfhvl
       61 flffvsamff isvlslfsyh cwlvgknrtt iesfraptfs ygpdgngfsl gcsknwrqvf
      121 gdekkywllp ifsslgdgcs fptrlvgmdp eqasvtnqne yarssgsnqp fpikplsesk
      181 nrlldsesqw lengaeegiv ksgtnnhvtv aien
//
LOCUS       XP_005266389             886 aa            linear   PRI 05-AUG-2025
DEFINITION  PAN2-PAN3 deadenylation complex subunit PAN3 isoform X1 [Homo
            sapiens].
ACCESSION   XP_005266389
VERSION     XP_005266389.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266332.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..886
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..886
                     /product="PAN2-PAN3 deadenylation complex subunit PAN3
                     isoform X1"
                     /calculated_mol_wt=95411
     Region          45..68
                     /region_name="zf-CCCH"
                     /note="Zinc finger C-x8-C-x5-C-x3-H type (and similar);
                     pfam00642"
                     /db_xref="CDD:459885"
     Region          492..>660
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Site            order(497..500,503,505,518,520,548,564..567,639,643..644,
                     646,656..657)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270870"
     Region          <609..732
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Region          741..878
                     /region_name="Pan3_PK"
                     /note="Pan3 Pseudokinase domain; pfam18101"
                     /db_xref="CDD:465649"
     CDS             1..886
                     /gene="PAN3"
                     /coded_by="XM_005266332.4:114..2774"
                     /db_xref="GeneID:255967"
                     /db_xref="HGNC:HGNC:29991"
                     /db_xref="MIM:617448"
ORIGIN      
        1 mnsggglppp saaaspssss laaavavvap pgvggvpgga avgvklkycr yyakdktcfy
       61 geecqflhed paagaapglg lhsnsvplal agapvagfpp gavagggagp ppgpkkpdlg
      121 dpgtgaaagg ggssggldgp rlaipgmdgg altdtsltds yfstsfigvn gfgspvetky
      181 plmqrmtnss sspsllndsa kpysahdplt spasslfndf galnisqrrk prkyrlgmle
      241 erlvpmgska rkaknpigcl adrcksgvpi nmvwwnrvte nnlqtpnpta sefipkggst
      301 srlsnvsqsn msafsqvfsh psmgspatag lapgmslsag ssplhspkit phtspaprrr
      361 shtpnpasym vpssastsvn npvsqtpssg qviqketvgg ttyfytdttp apltgmvfpn
      421 yhiypptaph vaymqpkana psffmadelr qelinrhlit maqidqadmp vptevdsyhs
      481 lfpleplppp nriqkssnfg yitscykavn skddlpyclr rihgfrlvnt kcmvlvdmwk
      541 kiqhsnivtl revfttkafa epslvfaydf haggetmmsr hfndpnaday ftkrkwgqhe
      601 gplprqhagl lpesliwayi vqlssalrti htaglacrvm dptkilitgk trlrvncvgv
      661 fdvltfdnsq nnnplalmaq yqqadlislg kvvlalacns lagiqrenlq kamelvtiny
      721 ssdlknlily lltdqnrmrs vndimpmiga rfytqldaaq mrndvieedl akevqngrlf
      781 rllaklgtin erpefqkdpt wsetgdryll klfrdhlfhq vteagapwid lshiisclnk
      841 ldagvpekis lisrdeksvl vvtysdlkrc fentfqelia aangql
//
LOCUS       XP_005266390             833 aa            linear   PRI 05-AUG-2025
DEFINITION  PAN2-PAN3 deadenylation complex subunit PAN3 isoform X2 [Homo
            sapiens].
ACCESSION   XP_005266390
VERSION     XP_005266390.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266333.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..833
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..833
                     /product="PAN2-PAN3 deadenylation complex subunit PAN3
                     isoform X2"
                     /calculated_mol_wt=89274
     Region          45..68
                     /region_name="zf-CCCH"
                     /note="Zinc finger C-x8-C-x5-C-x3-H type (and similar);
                     pfam00642"
                     /db_xref="CDD:459885"
     Region          <202..>385
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          439..>607
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Site            order(444..447,450,452,465,467,495,511..514,586,590..591,
                     593,603..604)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270870"
     Region          <556..679
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Region          688..825
                     /region_name="Pan3_PK"
                     /note="Pan3 Pseudokinase domain; pfam18101"
                     /db_xref="CDD:465649"
     CDS             1..833
                     /gene="PAN3"
                     /coded_by="XM_005266333.4:114..2615"
                     /db_xref="GeneID:255967"
                     /db_xref="HGNC:HGNC:29991"
                     /db_xref="MIM:617448"
ORIGIN      
        1 mnsggglppp saaaspssss laaavavvap pgvggvpgga avgvklkycr yyakdktcfy
       61 geecqflhed paagaapglg lhsnsvplal agapvagfpp gavagggagp ppgpkkpdlg
      121 dpgtgaaagg ggssggldgp rlaipgmdgg altdtsltds yfstsfigvn gfgspvetky
      181 plmqrmtnss sspsllndsa kpysahdplt spasslfndf galnisqrrk tpnptasefi
      241 pkggstsrls nvsqsnmsaf sqvfshpsmg spataglapg mslsagsspl hspkitphts
      301 paprrrshtp npasymvpss astsvnnpvs qtpssgqviq ketvggttyf ytdttpaplt
      361 gmvfpnyhiy pptaphvaym qpkanapsff madelrqeli nrhlitmaqi dqadmpavpt
      421 evdsyhslfp leplpppnri qkssnfgyit scykavnskd dlpyclrrih gfrlvntkcm
      481 vlvdmwkkiq hsnivtlrev fttkafaeps lvfaydfhag getmmsrhfn dpnadayftk
      541 rkwgqhegpl prqhagllpe sliwayivql ssalrtihta glacrvmdpt kilitgktrl
      601 rvncvgvfdv ltfdnsqnnn plalmaqyqq adlislgkvv lalacnslag iqrenlqkam
      661 elvtinyssd lknlilyllt dqnrmrsvnd impmigarfy tqldaaqmrn dvieedlake
      721 vqngrlfrll aklgtinerp efqkdptwse tgdryllklf rdhlfhqvte agapwidlsh
      781 iisclnklda gvpekislis rdeksvlvvt ysdlkrcfen tfqeliaaan gql
//
LOCUS       XP_047286205             832 aa            linear   PRI 05-AUG-2025
DEFINITION  PAN2-PAN3 deadenylation complex subunit PAN3 isoform X3 [Homo
            sapiens].
ACCESSION   XP_047286205
VERSION     XP_047286205.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430249.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..832
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..832
                     /product="PAN2-PAN3 deadenylation complex subunit PAN3
                     isoform X3"
                     /calculated_mol_wt=89203
     Region          45..68
                     /region_name="zf-CCCH"
                     /note="Zinc finger C-x8-C-x5-C-x3-H type (and similar);
                     pfam00642"
                     /db_xref="CDD:459885"
     Region          <202..>385
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          438..>606
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Site            order(443..446,449,451,464,466,494,510..513,585,589..590,
                     592,602..603)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270870"
     Region          <555..678
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Region          687..824
                     /region_name="Pan3_PK"
                     /note="Pan3 Pseudokinase domain; pfam18101"
                     /db_xref="CDD:465649"
     CDS             1..832
                     /gene="PAN3"
                     /coded_by="XM_047430249.1:114..2612"
                     /db_xref="GeneID:255967"
                     /db_xref="HGNC:HGNC:29991"
                     /db_xref="MIM:617448"
ORIGIN      
        1 mnsggglppp saaaspssss laaavavvap pgvggvpgga avgvklkycr yyakdktcfy
       61 geecqflhed paagaapglg lhsnsvplal agapvagfpp gavagggagp ppgpkkpdlg
      121 dpgtgaaagg ggssggldgp rlaipgmdgg altdtsltds yfstsfigvn gfgspvetky
      181 plmqrmtnss sspsllndsa kpysahdplt spasslfndf galnisqrrk tpnptasefi
      241 pkggstsrls nvsqsnmsaf sqvfshpsmg spataglapg mslsagsspl hspkitphts
      301 paprrrshtp npasymvpss astsvnnpvs qtpssgqviq ketvggttyf ytdttpaplt
      361 gmvfpnyhiy pptaphvaym qpkanapsff madelrqeli nrhlitmaqi dqadmpvpte
      421 vdsyhslfpl eplpppnriq kssnfgyits cykavnskdd lpyclrrihg frlvntkcmv
      481 lvdmwkkiqh snivtlrevf ttkafaepsl vfaydfhagg etmmsrhfnd pnadayftkr
      541 kwgqhegplp rqhagllpes liwayivqls salrtihtag lacrvmdptk ilitgktrlr
      601 vncvgvfdvl tfdnsqnnnp lalmaqyqqa dlislgkvvl alacnslagi qrenlqkame
      661 lvtinyssdl knlilylltd qnrmrsvndi mpmigarfyt qldaaqmrnd vieedlakev
      721 qngrlfrlla klgtinerpe fqkdptwset gdryllklfr dhlfhqvtea gapwidlshi
      781 isclnkldag vpekislisr deksvlvvty sdlkrcfent fqeliaaang ql
//
LOCUS       XP_011533334             795 aa            linear   PRI 05-AUG-2025
DEFINITION  PAN2-PAN3 deadenylation complex subunit PAN3 isoform X4 [Homo
            sapiens].
ACCESSION   XP_011533334
VERSION     XP_011533334.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535032.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..795
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..795
                     /product="PAN2-PAN3 deadenylation complex subunit PAN3
                     isoform X4"
                     /calculated_mol_wt=84993
     Region          45..68
                     /region_name="zf-CCCH"
                     /note="Zinc finger C-x8-C-x5-C-x3-H type (and similar);
                     pfam00642"
                     /db_xref="CDD:459885"
     Region          493..>661
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Site            order(498..501,504,506,519,521,549,565..568,640,644..645,
                     647,657..658)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270865"
     Region          <610..733
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Region          742..>795
                     /region_name="Pan3_PK"
                     /note="Pan3 Pseudokinase domain; pfam18101"
                     /db_xref="CDD:465649"
     CDS             1..795
                     /gene="PAN3"
                     /coded_by="XM_011535032.4:114..2501"
                     /db_xref="GeneID:255967"
                     /db_xref="HGNC:HGNC:29991"
                     /db_xref="MIM:617448"
ORIGIN      
        1 mnsggglppp saaaspssss laaavavvap pgvggvpgga avgvklkycr yyakdktcfy
       61 geecqflhed paagaapglg lhsnsvplal agapvagfpp gavagggagp ppgpkkpdlg
      121 dpgtgaaagg ggssggldgp rlaipgmdgg altdtsltds yfstsfigvn gfgspvetky
      181 plmqrmtnss sspsllndsa kpysahdplt spasslfndf galnisqrrk prkyrlgmle
      241 erlvpmgska rkaknpigcl adrcksgvpi nmvwwnrvte nnlqtpnpta sefipkggst
      301 srlsnvsqsn msafsqvfsh psmgspatag lapgmslsag ssplhspkit phtspaprrr
      361 shtpnpasym vpssastsvn npvsqtpssg qviqketvgg ttyfytdttp apltgmvfpn
      421 yhiypptaph vaymqpkana psffmadelr qelinrhlit maqidqadmp avptevdsyh
      481 slfpleplpp pnriqkssnf gyitscykav nskddlpycl rrihgfrlvn tkcmvlvdmw
      541 kkiqhsnivt lrevfttkaf aepslvfayd fhaggetmms rhfndpnada yftkrkwgqh
      601 egplprqhag llpesliway ivqlssalrt ihtaglacrv mdptkilitg ktrlrvncvg
      661 vfdvltfdns qnnnplalma qyqqadlisl gkvvlalacn slagiqrenl qkamelvtin
      721 yssdlknlil ylltdqnrmr svndimpmig arfytqldaa qmrndvieed lakevqngrl
      781 frllaklgti nerpd
//
LOCUS       XP_011533335             743 aa            linear   PRI 05-AUG-2025
DEFINITION  PAN2-PAN3 deadenylation complex subunit PAN3 isoform X5 [Homo
            sapiens].
ACCESSION   XP_011533335
VERSION     XP_011533335.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535033.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..743
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..743
                     /product="PAN2-PAN3 deadenylation complex subunit PAN3
                     isoform X5"
                     /calculated_mol_wt=78871
     Region          45..68
                     /region_name="zf-CCCH"
                     /note="Zinc finger C-x8-C-x5-C-x3-H type (and similar);
                     pfam00642"
                     /db_xref="CDD:459885"
     Region          493..>661
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Site            order(498..501,504,506,519,521,549,565..568,640,644..645,
                     647,657..658)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270865"
     Region          <610..729
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..743
                     /gene="PAN3"
                     /coded_by="XM_011535033.3:114..2345"
                     /db_xref="GeneID:255967"
                     /db_xref="HGNC:HGNC:29991"
                     /db_xref="MIM:617448"
ORIGIN      
        1 mnsggglppp saaaspssss laaavavvap pgvggvpgga avgvklkycr yyakdktcfy
       61 geecqflhed paagaapglg lhsnsvplal agapvagfpp gavagggagp ppgpkkpdlg
      121 dpgtgaaagg ggssggldgp rlaipgmdgg altdtsltds yfstsfigvn gfgspvetky
      181 plmqrmtnss sspsllndsa kpysahdplt spasslfndf galnisqrrk prkyrlgmle
      241 erlvpmgska rkaknpigcl adrcksgvpi nmvwwnrvte nnlqtpnpta sefipkggst
      301 srlsnvsqsn msafsqvfsh psmgspatag lapgmslsag ssplhspkit phtspaprrr
      361 shtpnpasym vpssastsvn npvsqtpssg qviqketvgg ttyfytdttp apltgmvfpn
      421 yhiypptaph vaymqpkana psffmadelr qelinrhlit maqidqadmp avptevdsyh
      481 slfpleplpp pnriqkssnf gyitscykav nskddlpycl rrihgfrlvn tkcmvlvdmw
      541 kkiqhsnivt lrevfttkaf aepslvfayd fhaggetmms rhfndpnada yftkrkwgqh
      601 egplprqhag llpesliway ivqlssalrt ihtaglacrv mdptkilitg ktrlrvncvg
      661 vfdvltfdns qnnnplalma qyqqadlisl gkvvlalacn slagiqrenl qkamelvtin
      721 yssdlknlif lqlpiliflc spg
//
LOCUS       XP_047286206             741 aa            linear   PRI 05-AUG-2025
DEFINITION  PAN2-PAN3 deadenylation complex subunit PAN3 isoform X6 [Homo
            sapiens].
ACCESSION   XP_047286206
VERSION     XP_047286206.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430250.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..741
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..741
                     /product="PAN2-PAN3 deadenylation complex subunit PAN3
                     isoform X6"
                     /calculated_mol_wt=78785
     Region          45..68
                     /region_name="zf-CCCH"
                     /note="Zinc finger C-x8-C-x5-C-x3-H type (and similar);
                     pfam00642"
                     /db_xref="CDD:459885"
     Region          <202..>385
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          439..>607
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Site            order(444..447,450,452,465,467,495,511..514,586,590..591,
                     593,603..604)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270870"
     Region          <556..679
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Region          688..>741
                     /region_name="Pan3_PK"
                     /note="Pan3 Pseudokinase domain; pfam18101"
                     /db_xref="CDD:465649"
     CDS             1..741
                     /gene="PAN3"
                     /coded_by="XM_047430250.1:114..2339"
                     /db_xref="GeneID:255967"
                     /db_xref="HGNC:HGNC:29991"
                     /db_xref="MIM:617448"
ORIGIN      
        1 mnsggglppp saaaspssss laaavavvap pgvggvpgga avgvklkycr yyakdktcfy
       61 geecqflhed paagaapglg lhsnsvplal agapvagfpp gavagggagp ppgpkkpdlg
      121 dpgtgaaagg ggssggldgp rlaipgmdgg altdtsltds yfstsfigvn gfgspvetky
      181 plmqrmtnss sspsllndsa kpysahdplt spasslfndf galnisqrrk tpnptasefi
      241 pkggstsrls nvsqsnmsaf sqvfshpsmg spataglapg mslsagsspl hspkitphts
      301 paprrrshtp npasymvpss astsvnnpvs qtpssgqviq ketvggttyf ytdttpaplt
      361 gmvfpnyhiy pptaphvaym qpkanapsff madelrqeli nrhlitmaqi dqadmpavpt
      421 evdsyhslfp leplpppnri qkssnfgyit scykavnskd dlpyclrrih gfrlvntkcm
      481 vlvdmwkkiq hsnivtlrev fttkafaeps lvfaydfhag getmmsrhfn dpnadayftk
      541 rkwgqhegpl prqhagllpe sliwayivql ssalrtihta glacrvmdpt kilitgktrl
      601 rvncvgvfdv ltfdnsqnnn plalmaqyqq adlislgkvv lalacnslag iqrenlqkam
      661 elvtinyssd lknlilyllt dqnrmrsvnd impmigarfy tqldaaqmrn dvieedlake
      721 vqngrlfrll aklgtinerp d
//
LOCUS       XP_011533336             741 aa            linear   PRI 05-AUG-2025
DEFINITION  PAN2-PAN3 deadenylation complex subunit PAN3 isoform X12 [Homo
            sapiens].
ACCESSION   XP_011533336
VERSION     XP_011533336.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535034.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..741
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..741
                     /product="PAN2-PAN3 deadenylation complex subunit PAN3
                     isoform X12"
                     /calculated_mol_wt=82050
     Region          347..>515
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Site            order(352..355,358,360,373,375,403,419..422,494,498..499,
                     501,511..512)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270870"
     Region          <464..587
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Region          596..733
                     /region_name="Pan3_PK"
                     /note="Pan3 Pseudokinase domain; pfam18101"
                     /db_xref="CDD:465649"
     CDS             1..741
                     /gene="PAN3"
                     /coded_by="XM_011535034.4:245..2470"
                     /db_xref="GeneID:255967"
                     /db_xref="HGNC:HGNC:29991"
                     /db_xref="MIM:617448"
ORIGIN      
        1 mdggaltdts ltdsyfstsf igvngfgspv etkyplmqrm tnsssspsll ndsakpysah
       61 dpltspassl fndfgalnis qrrkprkyrl gmleerlvpm gskarkaknp igcladrcks
      121 gvpinmvwwn rvtennlqtp nptasefipk ggstsrlsnv sqsnmsafsq vfshpsmgsp
      181 ataglapgms lsagssplhs pkitphtspa prrrshtpnp asymvpssas tsvnnpvsqt
      241 pssgqviqke tvggttyfyt dttpapltgm vfpnyhiypp taphvaymqp kanapsffma
      301 delrqelinr hlitmaqidq admpavptev dsyhslfple plpppnriqk ssnfgyitsc
      361 ykavnskddl pyclrrihgf rlvntkcmvl vdmwkkiqhs nivtlrevft tkafaepslv
      421 faydfhagge tmmsrhfndp nadayftkrk wgqhegplpr qhagllpesl iwayivqlss
      481 alrtihtagl acrvmdptki litgktrlrv ncvgvfdvlt fdnsqnnnpl almaqyqqad
      541 lislgkvvla lacnslagiq renlqkamel vtinyssdlk nlilylltdq nrmrsvndim
      601 pmigarfytq ldaaqmrndv ieedlakevq ngrlfrllak lgtinerpef qkdptwsetg
      661 dryllklfrd hlfhqvteag apwidlshii sclnkldagv pekislisrd eksvlvvtys
      721 dlkrcfentf qeliaaangq l
//
LOCUS       XP_016876017             693 aa            linear   PRI 05-AUG-2025
DEFINITION  PAN2-PAN3 deadenylation complex subunit PAN3 isoform X7 [Homo
            sapiens].
ACCESSION   XP_016876017
VERSION     XP_016876017.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020528.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..693
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..693
                     /product="PAN2-PAN3 deadenylation complex subunit PAN3
                     isoform X7"
                     /calculated_mol_wt=73567
     Region          45..68
                     /region_name="zf-CCCH"
                     /note="Zinc finger C-x8-C-x5-C-x3-H type (and similar);
                     pfam00642"
                     /db_xref="CDD:459885"
     Region          493..>661
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Site            order(498..501,504,506,519,521,549,565..568,640,644..645,
                     647,657..658)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270870"
     CDS             1..693
                     /gene="PAN3"
                     /coded_by="XM_017020528.2:114..2195"
                     /db_xref="GeneID:255967"
                     /db_xref="HGNC:HGNC:29991"
                     /db_xref="MIM:617448"
ORIGIN      
        1 mnsggglppp saaaspssss laaavavvap pgvggvpgga avgvklkycr yyakdktcfy
       61 geecqflhed paagaapglg lhsnsvplal agapvagfpp gavagggagp ppgpkkpdlg
      121 dpgtgaaagg ggssggldgp rlaipgmdgg altdtsltds yfstsfigvn gfgspvetky
      181 plmqrmtnss sspsllndsa kpysahdplt spasslfndf galnisqrrk prkyrlgmle
      241 erlvpmgska rkaknpigcl adrcksgvpi nmvwwnrvte nnlqtpnpta sefipkggst
      301 srlsnvsqsn msafsqvfsh psmgspatag lapgmslsag ssplhspkit phtspaprrr
      361 shtpnpasym vpssastsvn npvsqtpssg qviqketvgg ttyfytdttp apltgmvfpn
      421 yhiypptaph vaymqpkana psffmadelr qelinrhlit maqidqadmp avptevdsyh
      481 slfpleplpp pnriqkssnf gyitscykav nskddlpycl rrihgfrlvn tkcmvlvdmw
      541 kkiqhsnivt lrevfttkaf aepslvfayd fhaggetmms rhfndpnada yftkrkwgqh
      601 egplprqhag llpesliway ivqlssalrt ihtaglacrv mdptkilitg ktrlrvncvg
      661 vfdvltfdns qnnnplalma qyqrimeysg rea
//
LOCUS       XP_047286207             661 aa            linear   PRI 05-AUG-2025
DEFINITION  PAN2-PAN3 deadenylation complex subunit PAN3 isoform X8 [Homo
            sapiens].
ACCESSION   XP_047286207
VERSION     XP_047286207.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430251.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..661
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..661
                     /product="PAN2-PAN3 deadenylation complex subunit PAN3
                     isoform X8"
                     /calculated_mol_wt=73553
     Region          267..>435
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Site            order(272..275,278,280,293,295,323,339..342,414,418..419,
                     421,431..432)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270865"
     Region          <384..507
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Region          516..653
                     /region_name="Pan3_PK"
                     /note="Pan3 Pseudokinase domain; pfam18101"
                     /db_xref="CDD:465649"
     CDS             1..661
                     /gene="PAN3"
                     /coded_by="XM_047430251.1:87..2072"
                     /db_xref="GeneID:255967"
                     /db_xref="HGNC:HGNC:29991"
                     /db_xref="MIM:617448"
ORIGIN      
        1 mlpqprkyrl gmleerlvpm gskarkaknp igcladrcks gvpinmvwwn rvtennlqtp
       61 nptasefipk ggstsrlsnv sqsnmsafsq vfshpsmgsp ataglapgms lsagssplhs
      121 pkitphtspa prrrshtpnp asymvpssas tsvnnpvsqt pssgqviqke tvggttyfyt
      181 dttpapltgm vfpnyhiypp taphvaymqp kanapsffma delrqelinr hlitmaqidq
      241 admpavptev dsyhslfple plpppnriqk ssnfgyitsc ykavnskddl pyclrrihgf
      301 rlvntkcmvl vdmwkkiqhs nivtlrevft tkafaepslv faydfhagge tmmsrhfndp
      361 nadayftkrk wgqhegplpr qhagllpesl iwayivqlss alrtihtagl acrvmdptki
      421 litgktrlrv ncvgvfdvlt fdnsqnnnpl almaqyqqad lislgkvvla lacnslagiq
      481 renlqkamel vtinyssdlk nlilylltdq nrmrsvndim pmigarfytq ldaaqmrndv
      541 ieedlakevq ngrlfrllak lgtinerpef qkdptwsetg dryllklfrd hlfhqvteag
      601 apwidlshii sclnkldagv pekislisrd eksvlvvtys dlkrcfentf qeliaaangq
      661 l
//
LOCUS       XP_016876019             656 aa            linear   PRI 05-AUG-2025
DEFINITION  PAN2-PAN3 deadenylation complex subunit PAN3 isoform X9 [Homo
            sapiens].
ACCESSION   XP_016876019
VERSION     XP_016876019.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020530.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..656
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..656
                     /product="PAN2-PAN3 deadenylation complex subunit PAN3
                     isoform X9"
                     /calculated_mol_wt=69307
     Region          45..68
                     /region_name="zf-CCCH"
                     /note="Zinc finger C-x8-C-x5-C-x3-H type (and similar);
                     pfam00642"
                     /db_xref="CDD:459885"
     Region          493..>650
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Site            order(498..501,504,506,519,521,549,565..568,640,644..645,
                     647)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270870"
     CDS             1..656
                     /gene="PAN3"
                     /coded_by="XM_017020530.3:114..2084"
                     /db_xref="GeneID:255967"
                     /db_xref="HGNC:HGNC:29991"
                     /db_xref="MIM:617448"
ORIGIN      
        1 mnsggglppp saaaspssss laaavavvap pgvggvpgga avgvklkycr yyakdktcfy
       61 geecqflhed paagaapglg lhsnsvplal agapvagfpp gavagggagp ppgpkkpdlg
      121 dpgtgaaagg ggssggldgp rlaipgmdgg altdtsltds yfstsfigvn gfgspvetky
      181 plmqrmtnss sspsllndsa kpysahdplt spasslfndf galnisqrrk prkyrlgmle
      241 erlvpmgska rkaknpigcl adrcksgvpi nmvwwnrvte nnlqtpnpta sefipkggst
      301 srlsnvsqsn msafsqvfsh psmgspatag lapgmslsag ssplhspkit phtspaprrr
      361 shtpnpasym vpssastsvn npvsqtpssg qviqketvgg ttyfytdttp apltgmvfpn
      421 yhiypptaph vaymqpkana psffmadelr qelinrhlit maqidqadmp avptevdsyh
      481 slfpleplpp pnriqkssnf gyitscykav nskddlpycl rrihgfrlvn tkcmvlvdmw
      541 kkiqhsnivt lrevfttkaf aepslvfayd fhaggetmms rhfndpnada yftkrkwgqh
      601 egplprqhag llpesliway ivqlssalrt ihtaglacrv mdptkilitg ktskqi
//
LOCUS       XP_047286208             575 aa            linear   PRI 05-AUG-2025
DEFINITION  PAN2-PAN3 deadenylation complex subunit PAN3 isoform X10 [Homo
            sapiens].
ACCESSION   XP_047286208
VERSION     XP_047286208.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430252.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..575
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..575
                     /product="PAN2-PAN3 deadenylation complex subunit PAN3
                     isoform X10"
                     /calculated_mol_wt=64334
     Region          181..>349
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Site            order(186..189,192,194,207,209,237,253..256,328,332..333,
                     335,345..346)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270870"
     Region          <298..421
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Region          430..567
                     /region_name="Pan3_PK"
                     /note="Pan3 Pseudokinase domain; pfam18101"
                     /db_xref="CDD:465649"
     CDS             1..575
                     /gene="PAN3"
                     /coded_by="XM_047430252.1:157..1884"
                     /db_xref="GeneID:255967"
                     /db_xref="HGNC:HGNC:29991"
                     /db_xref="MIM:617448"
ORIGIN      
        1 mkltdstkgw ivwaaldssm rgmslsagss plhspkitph tspaprrrsh tpnpasymvp
       61 ssastsvnnp vsqtpssgqv iqketvggtt yfytdttpap ltgmvfpnyh iypptaphva
      121 ymqpkanaps ffmadelrqe linrhlitma qidqadmpav ptevdsyhsl fpleplpppn
      181 riqkssnfgy itscykavns kddlpyclrr ihgfrlvntk cmvlvdmwkk iqhsnivtlr
      241 evfttkafae pslvfaydfh aggetmmsrh fndpnadayf tkrkwgqheg plprqhagll
      301 pesliwayiv qlssalrtih taglacrvmd ptkilitgkt rlrvncvgvf dvltfdnsqn
      361 nnplalmaqy qqadlislgk vvlalacnsl agiqrenlqk amelvtinys sdlknlilyl
      421 ltdqnrmrsv ndimpmigar fytqldaaqm rndvieedla kevqngrlfr llaklgtine
      481 rpefqkdptw setgdryllk lfrdhlfhqv teagapwidl shiisclnkl dagvpekisl
      541 isrdeksvlv vtysdlkrcf entfqeliaa angql
//
LOCUS       XP_047286209             553 aa            linear   PRI 05-AUG-2025
DEFINITION  PAN2-PAN3 deadenylation complex subunit PAN3 isoform X11 [Homo
            sapiens].
ACCESSION   XP_047286209
VERSION     XP_047286209.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430253.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..553
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..553
                     /product="PAN2-PAN3 deadenylation complex subunit PAN3
                     isoform X11"
                     /calculated_mol_wt=61898
     Region          159..>327
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Site            order(164..167,170,172,185,187,215,231..234,306,310..311,
                     313,323..324)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270870"
     Region          <276..399
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Region          408..545
                     /region_name="Pan3_PK"
                     /note="Pan3 Pseudokinase domain; pfam18101"
                     /db_xref="CDD:465649"
     CDS             1..553
                     /gene="PAN3"
                     /coded_by="XM_047430253.1:93..1754"
                     /db_xref="GeneID:255967"
                     /db_xref="HGNC:HGNC:29991"
                     /db_xref="MIM:617448"
ORIGIN      
        1 mslsagsspl hspkitphts paprrrshtp npasymvpss astsvnnpvs qtpssgqviq
       61 ketvggttyf ytdttpaplt gmvfpnyhiy pptaphvaym qpkanapsff madelrqeli
      121 nrhlitmaqi dqadmpavpt evdsyhslfp leplpppnri qkssnfgyit scykavnskd
      181 dlpyclrrih gfrlvntkcm vlvdmwkkiq hsnivtlrev fttkafaeps lvfaydfhag
      241 getmmsrhfn dpnadayftk rkwgqhegpl prqhagllpe sliwayivql ssalrtihta
      301 glacrvmdpt kilitgktrl rvncvgvfdv ltfdnsqnnn plalmaqyqq adlislgkvv
      361 lalacnslag iqrenlqkam elvtinyssd lknlilyllt dqnrmrsvnd impmigarfy
      421 tqldaaqmrn dvieedlake vqngrlfrll aklgtinerp efqkdptwse tgdryllklf
      481 rdhlfhqvte agapwidlsh iisclnklda gvpekislis rdeksvlvvt ysdlkrcfen
      541 tfqeliaaan gql
//
LOCUS       XP_011519369            1757 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium leak channel NALCN isoform X1 [Homo sapiens].
ACCESSION   XP_011519369
VERSION     XP_011519369.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521067.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1757
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1757
                     /product="sodium leak channel NALCN isoform X1"
                     /calculated_mol_wt=202203
     Region          55..350
                     /region_name="Ion_trans"
                     /note="Ion transport protein; pfam00520"
                     /db_xref="CDD:459842"
     Region          402..622
                     /region_name="Ion_trans"
                     /note="Ion transport protein; pfam00520"
                     /db_xref="CDD:459842"
     Region          906..1180
                     /region_name="Ion_trans"
                     /note="Ion transport protein; pfam00520"
                     /db_xref="CDD:459842"
     Region          1228..1477
                     /region_name="Ion_trans"
                     /note="Ion transport protein; pfam00520"
                     /db_xref="CDD:459842"
     CDS             1..1757
                     /gene="NALCN"
                     /gene_synonym="bA430M15.1; CanIon; CLIFAHDD; IHPRF;
                     IHPRF1; INNFD; VGCNL1"
                     /coded_by="XM_011521067.3:46..5319"
                     /db_xref="GeneID:259232"
                     /db_xref="HGNC:HGNC:19082"
                     /db_xref="MIM:611549"
ORIGIN      
        1 mqsavqtvvl clltkanlsm lkrkqssrve aqpvtdfgpd eslsdnadil winkpwvhsl
       61 lricaiisvi svcmntpmtf ehypplqyvt ftldtllmfl ytaemiakmh irgivkgdss
      121 yvkdrwcvfd gfmvfclwvs lvlqvfeiad ivdqmspwgm lriprplimi rafriyfrfe
      181 lprtritnil krsgeqiwsv sifllfflll ygilgvqmfg tftyhcvvnd tkpgnvtwns
      241 laipdthcsp eleegyqcpp gfkcmdledl glsrqelgys gfneigtsif tvyeaasqeg
      301 wvflmyraid sfprwrsyfy fitlifflaw lvknvfiavi ietfaeirvq fqqmwgsrss
      361 ttstattqmf hedaaggwql vavdvnkpqg rapaclqkmm rssvfhmfil smvtvdviva
      421 asnyykgenf rrqydefyla evaftvlfdl eallkiwclg ftgyissslh kfelllvigt
      481 tlhvypdlyh sqftyfqvlr vvrlikispa ledfvykifg pgkklgslvv ftasllivms
      541 aislqmfcfv eeldrfttfp rafmsmfqil tqegwvdvmd qtlnavghmw apvvaiyfil
      601 yhlfatlill slfvavildn leldedlkkl kqlkqseana dtkeklplrl rifekfpnrp
      661 qmvkisklps dftvpkires fmkqfidrqq qdtccllrsl pttsssscdh skrsaiednk
      721 yidqklrksv fsirarnlle ketavtkilr actrqrmlsg sfegqpaker silsvqhhir
      781 qerrslrhgs nsqrisrgks letltqdhsn tvryrnaqre dseikmiqek keqaemkrkv
      841 qeeelrenhp yfdkplfivg rehrfrnfcr vvvrarfnas ktdpvtgavk ntkyhqlydl
      901 lglvtyldwv miivticsci smmfespfrr vmhaptlqia eyvfvifmsi elnlkimadg
      961 lfftptavir dfggvmdifi ylvsliflcw mpqnvpaesg aqllmvlrcl rplrifklvp
     1021 qmrkvvrelf sgfkeiflvs illltlmlvf asfgvqlfag klakcndpni irredcngif
     1081 rinvsvsknl nlklrpgekk pgfwvprvwa nprnfnfdnv gnamlalfev lslkgwvevr
     1141 dviihrvgpi hgiyihvfvf lgcmigltlf vgvvianfne nkgtalltvd qrrwedlksr
     1201 lkiaqplhlp prpdndgfra kmyditqhpf fkrtiallvl aqsvllsvkw dvedpvtvpl
     1261 atmsvvftfi fvlevtmkii amspagfwqs rrnrydllvt slgvvwvvlh fallnaytym
     1321 mgacvivfrf fsicgkhvtl kmllltvvvs myksffiivg mfllllcyaf agvvlfgtvk
     1381 ygeninrhan fssagkaitv lfrivtgedw nkimhdcmvq ppfctpdeft ywatdcgnya
     1441 galmyfcsfy viiayimlnl lvaiivenfs lfysteedql lsyndlrhfq iiwnmvddkr
     1501 egviptfrvk fllrllrgrl evdldkdkll fkhmcyemer lhnggdvtfh dvlsmlsyrs
     1561 vdirkslqle ellareqley tieeevakqt irmwlkkclk rirakqqqsc siihslresq
     1621 qqelsrflnp psiettqpse dtnansqdns mqpetssqqq llsptlsdrg gsrqdaadag
     1681 kpqrkfgqwr lpsapkpish svssvnlrfg grttmksvvc kmnpmtdaas cgsevkkwwt
     1741 rqltvesdes gddlldi
//
LOCUS       XP_011519371            1728 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium leak channel NALCN isoform X2 [Homo sapiens].
ACCESSION   XP_011519371
VERSION     XP_011519371.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521069.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1728
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1728
                     /product="sodium leak channel NALCN isoform X2"
                     /calculated_mol_wt=199111
     Region          55..350
                     /region_name="Ion_trans"
                     /note="Ion transport protein; pfam00520"
                     /db_xref="CDD:459842"
     Region          373..593
                     /region_name="Ion_trans"
                     /note="Ion transport protein; pfam00520"
                     /db_xref="CDD:459842"
     Region          877..1151
                     /region_name="Ion_trans"
                     /note="Ion transport protein; pfam00520"
                     /db_xref="CDD:459842"
     Region          1199..1448
                     /region_name="Ion_trans"
                     /note="Ion transport protein; pfam00520"
                     /db_xref="CDD:459842"
     CDS             1..1728
                     /gene="NALCN"
                     /gene_synonym="bA430M15.1; CanIon; CLIFAHDD; IHPRF;
                     IHPRF1; INNFD; VGCNL1"
                     /coded_by="XM_011521069.3:46..5232"
                     /db_xref="GeneID:259232"
                     /db_xref="HGNC:HGNC:19082"
                     /db_xref="MIM:611549"
ORIGIN      
        1 mqsavqtvvl clltkanlsm lkrkqssrve aqpvtdfgpd eslsdnadil winkpwvhsl
       61 lricaiisvi svcmntpmtf ehypplqyvt ftldtllmfl ytaemiakmh irgivkgdss
      121 yvkdrwcvfd gfmvfclwvs lvlqvfeiad ivdqmspwgm lriprplimi rafriyfrfe
      181 lprtritnil krsgeqiwsv sifllfflll ygilgvqmfg tftyhcvvnd tkpgnvtwns
      241 laipdthcsp eleegyqcpp gfkcmdledl glsrqelgys gfneigtsif tvyeaasqeg
      301 wvflmyraid sfprwrsyfy fitlifflaw lvknvfiavi ietfaeirvq fqqmwgsrss
      361 ttstattqkm mrssvfhmfi lsmvtvdviv aasnyykgen frrqydefyl aevaftvlfd
      421 leallkiwcl gftgyisssl hkfelllvig ttlhvypdly hsqftyfqvl rvvrlikisp
      481 aledfvykif gpgkklgslv vftasllivm saislqmfcf veeldrfttf prafmsmfqi
      541 ltqegwvdvm dqtlnavghm wapvvaiyfi lyhlfatlil lslfvavild nleldedlkk
      601 lkqlkqsean adtkeklplr lrifekfpnr pqmvkisklp sdftvpkire sfmkqfidrq
      661 qqdtccllrs lpttsssscd hskrsaiedn kyidqklrks vfsirarnll eketavtkil
      721 ractrqrmls gsfegqpake rsilsvqhhi rqerrslrhg snsqrisrgk sletltqdhs
      781 ntvryrnaqr edseikmiqe kkeqaemkrk vqeeelrenh pyfdkplfiv grehrfrnfc
      841 rvvvrarfna sktdpvtgav kntkyhqlyd llglvtyldw vmiivticsc ismmfespfr
      901 rvmhaptlqi aeyvfvifms ielnlkimad glfftptavi rdfggvmdif iylvsliflc
      961 wmpqnvpaes gaqllmvlrc lrplrifklv pqmrkvvrel fsgfkeiflv sillltlmlv
     1021 fasfgvqlfa gklakcndpn iirredcngi frinvsvskn lnlklrpgek kpgfwvprvw
     1081 anprnfnfdn vgnamlalfe vlslkgwvev rdviihrvgp ihgiyihvfv flgcmigltl
     1141 fvgvvianfn enkgtalltv dqrrwedlks rlkiaqplhl pprpdndgfr akmyditqhp
     1201 ffkrtiallv laqsvllsvk wdvedpvtvp latmsvvftf ifvlevtmki iamspagfwq
     1261 srrnrydllv tslgvvwvvl hfallnayty mmgacvivfr ffsicgkhvt lkmllltvvv
     1321 smyksffiiv gmfllllcya fagvvlfgtv kygeninrha nfssagkait vlfrivtged
     1381 wnkimhdcmv qppfctpdef tywatdcgny agalmyfcsf yviiayimln llvaiivenf
     1441 slfysteedq llsyndlrhf qiiwnmvddk regviptfrv kfllrllrgr levdldkdkl
     1501 lfkhmcyeme rlhnggdvtf hdvlsmlsyr svdirkslql eellareqle ytieeevakq
     1561 tirmwlkkcl krirakqqqs csiihslres qqqelsrfln ppsiettqps edtnansqdn
     1621 smqpetssqq qllsptlsdr ggsrqdaada gkpqrkfgqw rlpsapkpis hsvssvnlrf
     1681 ggrttmksvv ckmnpmtdaa scgsevkkww trqltvesde sgddlldi
//
LOCUS       XP_016876025            1589 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium leak channel NALCN isoform X3 [Homo sapiens].
ACCESSION   XP_016876025
VERSION     XP_016876025.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020536.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1589
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1589
                     /product="sodium leak channel NALCN isoform X3"
                     /calculated_mol_wt=182427
     Region          <107..182
                     /region_name="Ion_trans"
                     /note="Ion transport protein; pfam00520"
                     /db_xref="CDD:459842"
     Region          234..454
                     /region_name="Ion_trans"
                     /note="Ion transport protein; pfam00520"
                     /db_xref="CDD:459842"
     Region          738..1012
                     /region_name="Ion_trans"
                     /note="Ion transport protein; pfam00520"
                     /db_xref="CDD:459842"
     Region          1060..1309
                     /region_name="Ion_trans"
                     /note="Ion transport protein; pfam00520"
                     /db_xref="CDD:459842"
     CDS             1..1589
                     /gene="NALCN"
                     /gene_synonym="bA430M15.1; CanIon; CLIFAHDD; IHPRF;
                     IHPRF1; INNFD; VGCNL1"
                     /coded_by="XM_017020536.3:386..5155"
                     /db_xref="GeneID:259232"
                     /db_xref="HGNC:HGNC:19082"
                     /db_xref="MIM:611549"
ORIGIN      
        1 maelgsnpes ltlklrspvs lpsycyivgt kslmtsivde vhsictthse tesdqteakm
       61 nhlaymnvtw nslaipdthc speleegyqc ppgfkcmdle dlglsrqelg ysgfneigts
      121 iftvyeaasq egwvflmyra idsfprwrsy fyfitliffl awlvknvfia viietfaeir
      181 vqfqqmwgsr ssttstattq mfhedaaggw qlvavdvnkp qgrapaclqk mmrssvfhmf
      241 ilsmvtvdvi vaasnyykge nfrrqydefy laevaftvlf dleallkiwc lgftgyisss
      301 lhkfelllvi gttlhvypdl yhsqftyfqv lrvvrlikis paledfvyki fgpgkklgsl
      361 vvftaslliv msaislqmfc fveeldrftt fprafmsmfq iltqegwvdv mdqtlnavgh
      421 mwapvvaiyf ilyhlfatli llslfvavil dnleldedlk klkqlkqsea nadtkeklpl
      481 rlrifekfpn rpqmvkiskl psdftvpkir esfmkqfidr qqqdtccllr slpttssssc
      541 dhskrsaied nkyidqklrk svfsirarnl leketavtki lractrqrml sgsfegqpak
      601 ersilsvqhh irqerrslrh gsnsqrisrg ksletltqdh sntvryrnaq redseikmiq
      661 ekkeqaemkr kvqeeelren hpyfdkplfi vgrehrfrnf crvvvrarfn asktdpvtga
      721 vkntkyhqly dllglvtyld wvmiivtics cismmfespf rrvmhaptlq iaeyvfvifm
      781 sielnlkima dglfftptav irdfggvmdi fiylvslifl cwmpqnvpae sgaqllmvlr
      841 clrplrifkl vpqmrkvvre lfsgfkeifl vsillltlml vfasfgvqlf agklakcndp
      901 niirredcng ifrinvsvsk nlnlklrpge kkpgfwvprv wanprnfnfd nvgnamlalf
      961 evlslkgwve vrdviihrvg pihgiyihvf vflgcmiglt lfvgvvianf nenkgtallt
     1021 vdqrrwedlk srlkiaqplh lpprpdndgf rakmyditqh pffkrtiall vlaqsvllsv
     1081 kwdvedpvtv platmsvvft fifvlevtmk iiamspagfw qsrrnrydll vtslgvvwvv
     1141 lhfallnayt ymmgacvivf rffsicgkhv tlkmllltvv vsmyksffii vgmfllllcy
     1201 afagvvlfgt vkygeninrh anfssagkai tvlfrivtge dwnkimhdcm vqppfctpde
     1261 ftywatdcgn yagalmyfcs fyviiayiml nllvaiiven fslfysteed qllsyndlrh
     1321 fqiiwnmvdd kregviptfr vkfllrllrg rlevdldkdk llfkhmcyem erlhnggdvt
     1381 fhdvlsmlsy rsvdirkslq leellareql eytieeevak qtirmwlkkc lkrirakqqq
     1441 scsiihslre sqqqelsrfl nppsiettqp sedtnansqd nsmqpetssq qqllsptlsd
     1501 rggsrqdaad agkpqrkfgq wrlpsapkpi shsvssvnlr fggrttmksv vckmnpmtda
     1561 ascgsevkkw wtrqltvesd esgddlldi
//
LOCUS       XP_016876026            1483 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium leak channel NALCN isoform X4 [Homo sapiens].
ACCESSION   XP_016876026
VERSION     XP_016876026.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020537.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1483
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1483
                     /product="sodium leak channel NALCN isoform X4"
                     /calculated_mol_wt=170963
     Region          <13..76
                     /region_name="Ion_trans"
                     /note="Ion transport protein; pfam00520"
                     /db_xref="CDD:459842"
     Region          128..348
                     /region_name="Ion_trans"
                     /note="Ion transport protein; pfam00520"
                     /db_xref="CDD:459842"
     Region          632..906
                     /region_name="Ion_trans"
                     /note="Ion transport protein; pfam00520"
                     /db_xref="CDD:459842"
     Region          954..1203
                     /region_name="Ion_trans"
                     /note="Ion transport protein; pfam00520"
                     /db_xref="CDD:459842"
     CDS             1..1483
                     /gene="NALCN"
                     /gene_synonym="bA430M15.1; CanIon; CLIFAHDD; IHPRF;
                     IHPRF1; INNFD; VGCNL1"
                     /coded_by="XM_017020537.2:96..4547"
                     /db_xref="GeneID:259232"
                     /db_xref="HGNC:HGNC:19082"
                     /db_xref="MIM:611549"
ORIGIN      
        1 mntlhwlmnk nrtsiftvye aasqegwvfl myraidsfpr wrsyfyfitl ifflawlvkn
       61 vfiaviietf aeirvqfqqm wgsrssttst attqmfheda aggwqlvavd vnkpqgrapa
      121 clqkmmrssv fhmfilsmvt vdvivaasny ykgenfrrqy defylaevaf tvlfdleall
      181 kiwclgftgy issslhkfel llvigttlhv ypdlyhsqft yfqvlrvvrl ikispaledf
      241 vykifgpgkk lgslvvftas llivmsaisl qmfcfveeld rfttfprafm smfqiltqeg
      301 wvdvmdqtln avghmwapvv aiyfilyhlf atlillslfv avildnleld edlkklkqlk
      361 qseanadtke klplrlrife kfpnrpqmvk isklpsdftv pkiresfmkq fidrqqqdtc
      421 cllrslptts ssscdhskrs aiednkyidq klrksvfsir arnlleketa vtkilractr
      481 qrmlsgsfeg qpakersils vqhhirqerr slrhgsnsqr isrgksletl tqdhsntvry
      541 rnaqredsei kmiqekkeqa emkrkvqeee lrenhpyfdk plfivgrehr frnfcrvvvr
      601 arfnasktdp vtgavkntky hqlydllglv tyldwvmiiv ticscismmf espfrrvmha
      661 ptlqiaeyvf vifmsielnl kimadglfft ptavirdfgg vmdifiylvs liflcwmpqn
      721 vpaesgaqll mvlrclrplr ifklvpqmrk vvrelfsgfk eiflvsilll tlmlvfasfg
      781 vqlfagklak cndpniirre dcngifrinv svsknlnlkl rpgekkpgfw vprvwanprn
      841 fnfdnvgnam lalfevlslk gwvevrdvii hrvgpihgiy ihvfvflgcm igltlfvgvv
      901 ianfnenkgt alltvdqrrw edlksrlkia qplhlpprpd ndgfrakmyd itqhpffkrt
      961 iallvlaqsv llsvkwdved pvtvplatms vvftfifvle vtmkiiamsp agfwqsrrnr
     1021 ydllvtslgv vwvvlhfall naytymmgac vivfrffsic gkhvtlkmll ltvvvsmyks
     1081 ffiivgmfll llcyafagvv lfgtvkygen inrhanfssa gkaitvlfri vtgedwnkim
     1141 hdcmvqppfc tpdeftywat dcgnyagalm yfcsfyviia yimlnllvai ivenfslfys
     1201 teedqllsyn dlrhfqiiwn mvddkregvi ptfrvkfllr llrgrlevdl dkdkllfkhm
     1261 cyemerlhng gdvtfhdvls mlsyrsvdir kslqleella reqleytiee evakqtirmw
     1321 lkkclkrira kqqqscsiih slresqqqel srflnppsie ttqpsedtna nsqdnsmqpe
     1381 tssqqqllsp tlsdrggsrq daadagkpqr kfgqwrlpsa pkpishsvss vnlrfggrtt
     1441 mksvvckmnp mtdaascgse vkkwwtrqlt vesdesgddl ldi
//
LOCUS       XP_024305104            1786 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium leak channel NALCN isoform X5 [Homo sapiens].
ACCESSION   XP_024305104
VERSION     XP_024305104.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449336.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1786
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1786
                     /product="sodium leak channel NALCN isoform X5"
                     /calculated_mol_wt=205327
     Region          55..350
                     /region_name="Ion_trans"
                     /note="Ion transport protein; pfam00520"
                     /db_xref="CDD:459842"
     Region          402..622
                     /region_name="Ion_trans"
                     /note="Ion transport protein; pfam00520"
                     /db_xref="CDD:459842"
     Region          935..1209
                     /region_name="Ion_trans"
                     /note="Ion transport protein; pfam00520"
                     /db_xref="CDD:459842"
     Region          1257..1506
                     /region_name="Ion_trans"
                     /note="Ion transport protein; pfam00520"
                     /db_xref="CDD:459842"
     CDS             1..1786
                     /gene="NALCN"
                     /gene_synonym="bA430M15.1; CanIon; CLIFAHDD; IHPRF;
                     IHPRF1; INNFD; VGCNL1"
                     /coded_by="XM_024449336.2:46..5406"
                     /db_xref="GeneID:259232"
                     /db_xref="HGNC:HGNC:19082"
                     /db_xref="MIM:611549"
ORIGIN      
        1 mqsavqtvvl clltkanlsm lkrkqssrve aqpvtdfgpd eslsdnadil winkpwvhsl
       61 lricaiisvi svcmntpmtf ehypplqyvt ftldtllmfl ytaemiakmh irgivkgdss
      121 yvkdrwcvfd gfmvfclwvs lvlqvfeiad ivdqmspwgm lriprplimi rafriyfrfe
      181 lprtritnil krsgeqiwsv sifllfflll ygilgvqmfg tftyhcvvnd tkpgnvtwns
      241 laipdthcsp eleegyqcpp gfkcmdledl glsrqelgys gfneigtsif tvyeaasqeg
      301 wvflmyraid sfprwrsyfy fitlifflaw lvknvfiavi ietfaeirvq fqqmwgsrss
      361 ttstattqmf hedaaggwql vavdvnkpqg rapaclqkmm rssvfhmfil smvtvdviva
      421 asnyykgenf rrqydefyla evaftvlfdl eallkiwclg ftgyissslh kfelllvigt
      481 tlhvypdlyh sqftyfqvlr vvrlikispa ledfvykifg pgkklgslvv ftasllivms
      541 aislqmfcfv eeldrfttfp rafmsmfqil tqegwvdvmd qtlnavghmw apvvaiyfil
      601 yhlfatlill slfvavildn leldedlkkl kqlkqseana dtkeklplrl rifekfpnrp
      661 qmvkisklps dftvpkires fmkqfidrqq qdtccllrsl pttsssscdh skrsaiednk
      721 yidqklrksv fsirarnlle ketavtkils krplptsspi sircclylgr shchssgvra
      781 ctrqrmlsgs fegqpakers ilsvqhhirq errslrhgsn sqrisrgksl etltqdhsnt
      841 vryrnaqred seikmiqekk eqaemkrkvq eeelrenhpy fdkplfivgr ehrfrnfcrv
      901 vvrarfnask tdpvtgavkn tkyhqlydll glvtyldwvm iivticscis mmfespfrrv
      961 mhaptlqiae yvfvifmsie lnlkimadgl fftptavird fggvmdifiy lvsliflcwm
     1021 pqnvpaesga qllmvlrclr plrifklvpq mrkvvrelfs gfkeiflvsi llltlmlvfa
     1081 sfgvqlfagk lakcndpnii rredcngifr invsvsknln lklrpgekkp gfwvprvwan
     1141 prnfnfdnvg namlalfevl slkgwvevrd viihrvgpih giyihvfvfl gcmigltlfv
     1201 gvvianfnen kgtalltvdq rrwedlksrl kiaqplhlpp rpdndgfrak myditqhpff
     1261 krtiallvla qsvllsvkwd vedpvtvpla tmsvvftfif vlevtmkiia mspagfwqsr
     1321 rnrydllvts lgvvwvvlhf allnaytymm gacvivfrff sicgkhvtlk mllltvvvsm
     1381 yksffiivgm fllllcyafa gvvlfgtvky geninrhanf ssagkaitvl frivtgedwn
     1441 kimhdcmvqp pfctpdefty watdcgnyag almyfcsfyv iiayimlnll vaiivenfsl
     1501 fysteedqll syndlrhfqi iwnmvddkre gviptfrvkf llrllrgrle vdldkdkllf
     1561 khmcyemerl hnggdvtfhd vlsmlsyrsv dirkslqlee llareqleyt ieeevakqti
     1621 rmwlkkclkr irakqqqscs iihslresqq qelsrflnpp siettqpsed tnansqdnsm
     1681 qpetssqqql lsptlsdrgg srqdaadagk pqrkfgqwrl psapkpishs vssvnlrfgg
     1741 rttmksvvck mnpmtdaasc gsevkkwwtr qltvesdesg ddlldi
//
LOCUS       XP_005266393             428 aa            linear   PRI 05-AUG-2025
DEFINITION  F-box/LRR-repeat protein 3 isoform X1 [Homo sapiens].
ACCESSION   XP_005266393
VERSION     XP_005266393.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266336.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..428
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..428
                     /product="F-box/LRR-repeat protein 3 isoform X1"
                     /calculated_mol_wt=48576
     Region          34..76
                     /region_name="F-box_FBXL3"
                     /note="F-box domain found in F-box/LRR-repeat protein 3
                     (FBXL3) and similar proteins; cd22178"
                     /db_xref="CDD:438949"
     Site            order(35..37,39,43,46..47,50..51,53..55,57..64,66..67)
                     /site_type="other"
                     /note="Skp1 binding site [polypeptide binding]"
                     /db_xref="CDD:438949"
     Region          79..428
                     /region_name="FBXL3_LRR"
                     /note="Leucine-rich repeat domain of F-box/LRR-repeat
                     protein 3; cd23957"
                     /db_xref="CDD:467832"
     Site            order(82,92..93,95,97..98,101)
                     /site_type="other"
                     /note="SKP1 interface [polypeptide binding]"
                     /db_xref="CDD:467832"
     Site            order(86..91,119,145..149,181,207,254,256,258,260..262,
                     265,288,292,294,312,314,316..317,336,338..340,343,
                     364..368,389,391,393,406,423..428)
                     /site_type="other"
                     /note="CRY2 interface [polypeptide binding]"
                     /db_xref="CDD:467832"
     Region          174..199
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          200..225
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          252..286
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          287..333
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          334..360
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          361..383
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     CDS             1..428
                     /gene="FBXL3"
                     /gene_synonym="FBL3; FBL3A; FBXL3A; IDDSFAS"
                     /coded_by="XM_005266336.2:150..1436"
                     /db_xref="GeneID:26224"
                     /db_xref="HGNC:HGNC:13599"
                     /db_xref="MIM:605653"
ORIGIN      
        1 mkrggrdsdr nsseegtaek skklrttneh sqtcdwgnll qdiilqvfky lplldrahas
       61 qvcrnwnqvf hmpdlwrcfe felnqpatsy lkathpelik qiikrhsnhl qyvsfkvdss
      121 kesaeaacdi lsqlvncslk tlglistarp sfmdlpkshf isaltvvfvn skslsslkid
      181 dtpvddpslk vlvannsdtl kllkmsscph vspagilcva dqchglrela lnyhllsdel
      241 llalssekhv rlehlridvv senpgqthfh tiqksswdaf irhspkvnlv myfflyeeef
      301 dpffryeipa thlyfgrsvs kdvlgrvgmt cprlvelvvc anglrpldee liriaerckn
      361 lsaiglgece vscsafvefv kmcggrlsql simeevlipd qkysleqihw evskhlgrvw
      421 fpdmmptw
//
LOCUS       XP_047286210            4596 aa            linear   PRI 05-AUG-2025
DEFINITION  sacsin isoform X1 [Homo sapiens].
ACCESSION   XP_047286210
VERSION     XP_047286210.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430254.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4596
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..4596
                     /product="sacsin isoform X1"
                     /calculated_mol_wt=522947
     Region          15..86
                     /region_name="Ubl_Sacsin"
                     /note="ubiquitin-like (Ubl) domain found in Sacsin and
                     similar proteins; cd17049"
                     /db_xref="CDD:340569"
     Region          <4339..>4374
                     /region_name="DnaJ"
                     /note="DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock
                     protein 40) proteins are highly conserved and play crucial
                     roles in protein translation, folding, unfolding,
                     translocation, and degradation. They act primarily by
                     stimulating the ATPase activity of Hsp70s; cl02542"
                     /db_xref="CDD:413365"
     Region          4468..4584
                     /region_name="HEPN"
                     /note="Higher Eukarytoes and Prokaryotes
                     Nucleotide-binding domain; smart00748"
                     /db_xref="CDD:214800"
     CDS             1..4596
                     /gene="SACS"
                     /gene_synonym="ARSACS; DNAJC29; PPP1R138; SPAX6"
                     /coded_by="XM_047430254.1:38..13828"
                     /db_xref="GeneID:26278"
                     /db_xref="HGNC:HGNC:10519"
                     /db_xref="MIM:604490"
ORIGIN      
        1 mrippsrpar glwtrwvpvt vlpgcvgcrt vaalaswtvr dvkerifaet gfpvseqrlw
       61 rggrelsdwi kigdltsknc hlfvnlqskg lkgggrfgqt tpplvdflkd ilrrypeggq
      121 ilkeliqnae dagatevkfl ydetqygtet lwskdmapyq gpalyvynna vftpedwhgi
      181 qeiarsrkkd dplkvgrfgi gfnsvyhitd vpcifsgdqi gmldphqtlf gphesgqcwn
      241 lkddskeise lsdqfapfvg ifgstketfi ngnfpgtffr fplrlqpsql ssnlynkqkv
      301 lelfesfrad adtvllflks vqdvslyvre adgteklvfr vtsseskalk herpnsikil
      361 gtaisnyckk tpsnnitcvt yhvnivleee stkdaqktsw lvcnsvggrg isskldslad
      421 elkfvpiigi amplssrdde akgatsdfsg kafcflplpp geesstglpv hisgffgltd
      481 nrrsikwrel dqwrdpaalw neflvmnvvp kayatlilds ikrlemekss dfplsvdviy
      541 klwpeaskvk vhwqpvlepl fsellqnavi ysiscdwvrl eqvyfselde nleytktvln
      601 ylqssgkqia kvpgnvdaav qltaasgttp vrkvtpawvr qvlrkcahlg caeeklhlle
      661 fvlsdqayse llglellplq ngnfvpfsss vsdqdviyit saeyprslfp slegrfildn
      721 lkphlvaalk eaaqtraqqq lwgysgrpct qlqllnperf arlikevmnt fwpgrelivq
      781 wypfdenrnh psvswlkmvw knlyihfsed ltlfdempli prtileegqt cvelirlrip
      841 slvilddese aqlpefladi vqklggfvlk kldasiqhpl ikkyihsplp savlqimekm
      901 plqklcnqit sllpthkdal rkflasltds sekekriiqe laifkrinhs sdqgissytk
      961 lkgckvlhht aklpadlrls isvidssdea tirlanmlki eqlkttsclk lvlkdienaf
     1021 ysheevtqlm lwvlenlssl knenpnvlew ltplkfiqis qeqmvsagel fdpdievlkd
     1081 lfcneegtyf ppsvftspdi lhslrqiglk neaslkekdv vqvakkieal qvgacpdqdv
     1141 llkkaktlll vlnknhtllq ssegkmtlkk ikwvpacker ppnypgslvw kgdlcnlcap
     1201 pdmcdvghai ligsslplve sihvnlekal giftkpslsa vlkhfkivvd wyssktfsde
     1261 dyyqfqhill eiygfmhdhl negkdsfral kfpwvwtgkk fcplaqavik pihdldlqpy
     1321 lhnvpktmak fhqlfkvcgs ieeltsdhis mviqkiylks dqdlseqesk qnlhlmlnii
     1381 rwlysnqipa spntpvpihh sknpsklimk piheccycdi kvddlndlle dsvepiilvh
     1441 edipmktaew lkvpclstrl inpenmgfeq sgqrepltvr iknileeyps vsdifkellq
     1501 naddanatec sflidmrrnm direnlldpg maachgpalw sfnnsqfsds dfvnitrlge
     1561 slkrgevdkv gkfglgfnsv yhitdipiim srefmimfdp ninhiskhik dksnpgikin
     1621 wskqqkrlrk fpnqfkpfid vfgcqlpltv eapysyngtl frlsfrtqqe akvsevsstc
     1681 yntadiyslv defslcghrl iiftqsvksm ylkylkieet npslaqdtvi ikkkscsska
     1741 lntpvlsvlk eaaklmktcs ssnkklpsde pksscilqit veefhhvfrr iadlqsplfr
     1801 gpdddpaalf emaksgqskk psdelsqktv ecttwllctc mdtgealkfs lsesgrrlgl
     1861 vpcgavgvql seiqdqkwtv kphigevfcy lplriktglp vhingcfavt snrkeiwktd
     1921 tkgrwnttfm rhvivkaylq vlsvlrdlat sgelmdytyy avwpdpdlvh ddfsvicqgf
     1981 yediahgkgk eltkvfsdgs twvsmknvrf lddsilkrrd vgsaafkifl kylkktgskn
     2041 lcavelpssv klgfeeagck qillentfse kqffsevffp niqeieaelr dplmifvlne
     2101 kvdefsgvlr vtpcipcsle ghplvlpsrl ihpegrvakl fdikdgrfpy gstqdylnpi
     2161 iliklvqlgm akddilwddm leravsvaei nksdhvaacl rssillslid eklkirdpra
     2221 kdfaakyqti rflpfltkpa gfsldwkgns fkpetmfaat dlytaehqdi vcllqpilne
     2281 nshsfrgcgs vslavkeflg llkkptvdlv inqlkevaks vddgitlyqe nitnacykyl
     2341 healmqneit kmsiidklkp fsfilvenay vdsekvsfhl nfeaapylyq lpnkyknnfr
     2401 elfetvgvrq sctvedfalv lesidqergt kqiteenfql crriisegiw slirekkqef
     2461 ceknygkill pdtnlmllpa kslcyndcpw ikvkdttvky chadipreva vklgavpkrh
     2521 kaleryasnv cfttlgtefg qkekltsrik silnaypsek emlkellqna ddakateicf
     2581 vfdprqhpvd rifddkwapl qgpalcvynn qpfteddvrg iqnlgkgtke gnpyktgqyg
     2641 igfnsvyhit dcpsfisgnd ilcifdphar yapgatsisp grmfrdldad frtqfsdvld
     2701 lylgthfkld nctmfrfplr naemakvsei ssvpasdrmv qnlldklrsd gaellmflnh
     2761 mekisiceid kstgalnvly svkgkitdgd rlkrkqfhas vidsvtkkrq lkdipvqqit
     2821 ytmdtedseg nlttwlicnr sgfssmekvs ksvisahknq ditlfprggv aacithnykk
     2881 phrafcflpl sletglpfhv nghfaldsar rnlwrddngv gvrsdwnnsl mtaliapayv
     2941 elliqlkkry fpgsdptlsv lqntpihvvk dtlkkflsff pvnrldlqpd lyclvkalyn
     3001 cihedmkrll pvvrapnidg sdlhsaviit winmstsnkt rpffdnllqd elqhlknady
     3061 nittrktvae nvyrlkhlll eigfnlvync detanlyhcl idadipvsyv tpadirsflm
     3121 tfsspdtnch igklpcrlqq tnlklfhslk llvdycfkda eeneievegl pllitldsvl
     3181 qtfdakrpkf lttyhelips rkdlfmntly lkysnillnc kvakvfdiss fadllssvlp
     3241 reyktksctk wkdnfasesw lknawhfise svsvkedqee tkptfdivvd tlkdwallpg
     3301 tkftvsanql vvpegdvllp lslmhiavfp naqsdkvfha lmkagciqla lnkicskdsa
     3361 fvpllschta niesptsilk alhymvqtst fraeklvend feallmyfnc nlnhlmsqdd
     3421 ikilkslpcy ksisgryvsi gkfgtcyvlt ksipsaevek wtqssssafl eekihlkely
     3481 evigcvpvdd levylkhllp kienlsydak lehliylknr lssaeelsei keqlfekles
     3541 lliihdansr lkqakhfydr tvrvfevmlp eklfipndff kkleqlikpk nhvtfmtswv
     3601 eflrniglky ilsqqqllqf akeisvrant enwsketlqn tvdillhhif qermdllsgn
     3661 flkelslipf lcperapaef irfhpqyqev ngtlplikfn gaqvnpkfkq cdvlqllwts
     3721 cpilpekatp lsikeqegsd lgpqeqleqv lnmlnvnldp pldkvinncr nicnittlde
     3781 emvktrakvl rsiyeflsae krefrfqlrg vafvmvedgw kllkpeevvi nleyesdfkp
     3841 ylyklplelg tfhqlfkhlg tediistkqy vevlsrifkn segkqldpne mrtvkrvvsg
     3901 lfrslqndsv kvrsdlenvr dlalylpsqd grlvkssilv fddaphyksr iqgnigvqml
     3961 vdlsqcylgk dhgfhtklim lfpqklrprl lssileeqld eetpkvcqfg alcslqgrlq
     4021 lllsseqfit glirimkhen dnaflaneek airlckalre glkvscfekl qttlrvkgfn
     4081 piphsrsetf aflkrfgnav illyiqhsds kdinfllala mtlksatdnl isdtsyliam
     4141 lgcndiyrig ekldslgvky dssepsklel pmpgtpipae ihytllmdpm nvfypgeyvg
     4201 ylvdaeggdi ygsyqptyty aiivqevere dadnssflgk iyqidigyse ykivssldly
     4261 kfsrpeessq srdsapstpt sptefltpgl rsipplfsgr eshktsskhq spkklkvnsl
     4321 peilkevtsv veqawklpes erkkiirrly lkwhpdknpe nhdianevfk hlqneinrle
     4381 kqafldqnad rasrrtfsts asrfqsdkys fqrfytswnq eatshkserq qqnkekcpps
     4441 agqtysqrff vpptfksvgn pvearrwlrq aranfsaarn dlhknanewv cfkcylstkl
     4501 aliaadyavr gksdkdvkpt alaqkieeys qqlegltndv htleaygvds lktrypdllp
     4561 fpqipndrft sevamrvmec taciiiklen fmqqkv
//
LOCUS       XP_024305105            4588 aa            linear   PRI 05-AUG-2025
DEFINITION  sacsin isoform X2 [Homo sapiens].
ACCESSION   XP_024305105
VERSION     XP_024305105.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449337.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4588
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..4588
                     /product="sacsin isoform X2"
                     /calculated_mol_wt=522060
     Region          7..78
                     /region_name="Ubl_Sacsin"
                     /note="ubiquitin-like (Ubl) domain found in Sacsin and
                     similar proteins; cd17049"
                     /db_xref="CDD:340569"
     Region          <4331..>4366
                     /region_name="DnaJ"
                     /note="DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock
                     protein 40) proteins are highly conserved and play crucial
                     roles in protein translation, folding, unfolding,
                     translocation, and degradation. They act primarily by
                     stimulating the ATPase activity of Hsp70s; cl02542"
                     /db_xref="CDD:413365"
     Region          4460..4576
                     /region_name="HEPN"
                     /note="Higher Eukarytoes and Prokaryotes
                     Nucleotide-binding domain; smart00748"
                     /db_xref="CDD:214800"
     CDS             1..4588
                     /gene="SACS"
                     /gene_synonym="ARSACS; DNAJC29; PPP1R138; SPAX6"
                     /coded_by="XM_024449337.2:811..14577"
                     /db_xref="GeneID:26278"
                     /db_xref="HGNC:HGNC:10519"
                     /db_xref="MIM:604490"
ORIGIN      
        1 metkenrwvp vtvlpgcvgc rtvaalaswt vrdvkerifa etgfpvseqr lwrggrelsd
       61 wikigdltsk nchlfvnlqs kglkgggrfg qttpplvdfl kdilrrypeg gqilkeliqn
      121 aedagatevk flydetqygt etlwskdmap yqgpalyvyn navftpedwh giqeiarsrk
      181 kddplkvgrf gigfnsvyhi tdvpcifsgd qigmldphqt lfgphesgqc wnlkddskei
      241 selsdqfapf vgifgstket fingnfpgtf frfplrlqps qlssnlynkq kvlelfesfr
      301 adadtvllfl ksvqdvslyv readgteklv frvtsseska lkherpnsik ilgtaisnyc
      361 kktpsnnitc vtyhvnivle eestkdaqkt swlvcnsvgg rgisskldsl adelkfvpii
      421 giamplssrd deakgatsdf sgkafcflpl ppgeesstgl pvhisgffgl tdnrrsikwr
      481 eldqwrdpaa lwneflvmnv vpkayatlil dsikrlemek ssdfplsvdv iyklwpeask
      541 vkvhwqpvle plfsellqna viysiscdwv rleqvyfsel denleytktv lnylqssgkq
      601 iakvpgnvda avqltaasgt tpvrkvtpaw vrqvlrkcah lgcaeeklhl lefvlsdqay
      661 sellglellp lqngnfvpfs ssvsdqdviy itsaeyprsl fpslegrfil dnlkphlvaa
      721 lkeaaqtraq qqlwgysgrp ctqlqllnpe rfarlikevm ntfwpgreli vqwypfdenr
      781 nhpsvswlkm vwknlyihfs edltlfdemp liprtileeg qtcvelirlr ipslvildde
      841 seaqlpefla divqklggfv lkkldasiqh plikkyihsp lpsavlqime kmplqklcnq
      901 itsllpthkd alrkflaslt dssekekrii qelaifkrin hssdqgissy tklkgckvlh
      961 htaklpadlr lsisvidssd eatirlanml kieqlkttsc lklvlkdien afysheevtq
     1021 lmlwvlenls slknenpnvl ewltplkfiq isqeqmvsag elfdpdievl kdlfcneegt
     1081 yfppsvftsp dilhslrqig lkneaslkek dvvqvakkie alqvgacpdq dvllkkaktl
     1141 llvlnknhtl lqssegkmtl kkikwvpack erppnypgsl vwkgdlcnlc appdmcdvgh
     1201 ailigsslpl vesihvnlek algiftkpsl savlkhfkiv vdwyssktfs dedyyqfqhi
     1261 lleiygfmhd hlnegkdsfr alkfpwvwtg kkfcplaqav ikpihdldlq pylhnvpktm
     1321 akfhqlfkvc gsieeltsdh ismviqkiyl ksdqdlseqe skqnlhlmln iirwlysnqi
     1381 paspntpvpi hhsknpskli mkpiheccyc dikvddlndl ledsvepiil vhedipmkta
     1441 ewlkvpclst rlinpenmgf eqsgqreplt vriknileey psvsdifkel lqnaddanat
     1501 ecsflidmrr nmdirenlld pgmaachgpa lwsfnnsqfs dsdfvnitrl geslkrgevd
     1561 kvgkfglgfn svyhitdipi imsrefmimf dpninhiskh ikdksnpgik inwskqqkrl
     1621 rkfpnqfkpf idvfgcqlpl tveapysyng tlfrlsfrtq qeakvsevss tcyntadiys
     1681 lvdefslcgh rliiftqsvk smylkylkie etnpslaqdt viikkkscss kalntpvlsv
     1741 lkeaaklmkt csssnkklps depksscilq itveefhhvf rriadlqspl frgpdddpaa
     1801 lfemaksgqs kkpsdelsqk tvecttwllc tcmdtgealk fslsesgrrl glvpcgavgv
     1861 qlseiqdqkw tvkphigevf cylplriktg lpvhingcfa vtsnrkeiwk tdtkgrwntt
     1921 fmrhvivkay lqvlsvlrdl atsgelmdyt yyavwpdpdl vhddfsvicq gfyediahgk
     1981 gkeltkvfsd gstwvsmknv rflddsilkr rdvgsaafki flkylkktgs knlcavelps
     2041 svklgfeeag ckqillentf sekqffsevf fpniqeieae lrdplmifvl nekvdefsgv
     2101 lrvtpcipcs leghplvlps rlihpegrva klfdikdgrf pygstqdyln piiliklvql
     2161 gmakddilwd dmleravsva einksdhvaa clrssillsl ideklkirdp rakdfaakyq
     2221 tirflpfltk pagfsldwkg nsfkpetmfa atdlytaehq divcllqpil nenshsfrgc
     2281 gsvslavkef lgllkkptvd lvinqlkeva ksvddgitly qenitnacyk ylhealmqne
     2341 itkmsiidkl kpfsfilven ayvdsekvsf hlnfeaapyl yqlpnkyknn frelfetvgv
     2401 rqsctvedfa lvlesidqer gtkqiteenf qlcrriiseg iwslirekkq efceknygki
     2461 llpdtnlmll pakslcyndc pwikvkdttv kychadipre vavklgavpk rhkaleryas
     2521 nvcfttlgte fgqkekltsr iksilnayps ekemlkellq naddakatei cfvfdprqhp
     2581 vdrifddkwa plqgpalcvy nnqpfteddv rgiqnlgkgt kegnpyktgq ygigfnsvyh
     2641 itdcpsfisg ndilcifdph aryapgatsi spgrmfrdld adfrtqfsdv ldlylgthfk
     2701 ldnctmfrfp lrnaemakvs eissvpasdr mvqnlldklr sdgaellmfl nhmekisice
     2761 idkstgalnv lysvkgkitd gdrlkrkqfh asvidsvtkk rqlkdipvqq itytmdteds
     2821 egnlttwlic nrsgfssmek vsksvisahk nqditlfprg gvaacithny kkphrafcfl
     2881 plsletglpf hvnghfalds arrnlwrddn gvgvrsdwnn slmtaliapa yvelliqlkk
     2941 ryfpgsdptl svlqntpihv vkdtlkkfls ffpvnrldlq pdlyclvkal yncihedmkr
     3001 llpvvrapni dgsdlhsavi itwinmstsn ktrpffdnll qdelqhlkna dynittrktv
     3061 aenvyrlkhl lleigfnlvy ncdetanlyh clidadipvs yvtpadirsf lmtfsspdtn
     3121 chigklpcrl qqtnlklfhs lkllvdycfk daeeneieve glpllitlds vlqtfdakrp
     3181 kflttyheli psrkdlfmnt lylkysnill nckvakvfdi ssfadllssv lpreyktksc
     3241 tkwkdnfase swlknawhfi sesvsvkedq eetkptfdiv vdtlkdwall pgtkftvsan
     3301 qlvvpegdvl lplslmhiav fpnaqsdkvf halmkagciq lalnkicskd safvpllsch
     3361 taniesptsi lkalhymvqt stfraeklve ndfeallmyf ncnlnhlmsq ddikilkslp
     3421 cyksisgryv sigkfgtcyv ltksipsaev ekwtqssssa fleekihlke lyevigcvpv
     3481 ddlevylkhl lpkienlsyd aklehliylk nrlssaeels eikeqlfekl eslliihdan
     3541 srlkqakhfy drtvrvfevm lpeklfipnd ffkkleqlik pknhvtfmts wveflrnigl
     3601 kyilsqqqll qfakeisvra ntenwsketl qntvdillhh ifqermdlls gnflkelsli
     3661 pflcperapa efirfhpqyq evngtlplik fngaqvnpkf kqcdvlqllw tscpilpeka
     3721 tplsikeqeg sdlgpqeqle qvlnmlnvnl dppldkvinn crnicnittl deemvktrak
     3781 vlrsiyefls aekrefrfql rgvafvmved gwkllkpeev vinleyesdf kpylyklple
     3841 lgtfhqlfkh lgtediistk qyvevlsrif knsegkqldp nemrtvkrvv sglfrslqnd
     3901 svkvrsdlen vrdlalylps qdgrlvkssi lvfddaphyk sriqgnigvq mlvdlsqcyl
     3961 gkdhgfhtkl imlfpqklrp rllssileeq ldeetpkvcq fgalcslqgr lqlllsseqf
     4021 itglirimkh endnaflane ekairlckal reglkvscfe klqttlrvkg fnpiphsrse
     4081 tfaflkrfgn avillyiqhs dskdinflla lamtlksatd nlisdtsyli amlgcndiyr
     4141 igekldslgv kydssepskl elpmpgtpip aeihytllmd pmnvfypgey vgylvdaegg
     4201 diygsyqpty tyaiivqeve redadnssfl gkiyqidigy seykivssld lykfsrpees
     4261 sqsrdsapst ptsptefltp glrsipplfs greshktssk hqspkklkvn slpeilkevt
     4321 svveqawklp eserkkiirr lylkwhpdkn penhdianev fkhlqneinr lekqafldqn
     4381 adrasrrtfs tsasrfqsdk ysfqrfytsw nqeatshkse rqqqnkekcp psagqtysqr
     4441 ffvpptfksv gnpvearrwl rqaranfsaa rndlhknane wvcfkcylst klaliaadya
     4501 vrgksdkdvk ptalaqkiee ysqqlegltn dvhtleaygv dslktrypdl lpfpqipndr
     4561 ftsevamrvm ectaciiikl enfmqqkv
//
LOCUS       XP_047286211            4587 aa            linear   PRI 05-AUG-2025
DEFINITION  sacsin isoform X3 [Homo sapiens].
ACCESSION   XP_047286211
VERSION     XP_047286211.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430255.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4587
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..4587
                     /product="sacsin isoform X3"
                     /calculated_mol_wt=521885
     Region          15..86
                     /region_name="Ubl_Sacsin"
                     /note="ubiquitin-like (Ubl) domain found in Sacsin and
                     similar proteins; cd17049"
                     /db_xref="CDD:340569"
     Region          <4330..>4365
                     /region_name="DnaJ"
                     /note="DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock
                     protein 40) proteins are highly conserved and play crucial
                     roles in protein translation, folding, unfolding,
                     translocation, and degradation. They act primarily by
                     stimulating the ATPase activity of Hsp70s; cl02542"
                     /db_xref="CDD:413365"
     Region          4459..4575
                     /region_name="HEPN"
                     /note="Higher Eukarytoes and Prokaryotes
                     Nucleotide-binding domain; smart00748"
                     /db_xref="CDD:214800"
     CDS             1..4587
                     /gene="SACS"
                     /gene_synonym="ARSACS; DNAJC29; PPP1R138; SPAX6"
                     /coded_by="XM_047430255.1:38..13801"
                     /db_xref="GeneID:26278"
                     /db_xref="HGNC:HGNC:10519"
                     /db_xref="MIM:604490"
ORIGIN      
        1 mrippsrpar glwtrwvpvt vlpgcvgcrt vaalaswtvr dvkerifaet gfpvseqrlw
       61 rggrelsdwi kigdltsknc hlfvnlqskg lkgggrfgqt tpplvdflkd ilrrypeggq
      121 ilkeliqnae dagatevkfl ydetqygtet lwskdmapyq gpalyvynna vftpedwhgi
      181 qeiarsrkkd dplkvgrfgi gfnsvyhitd vpcifsgdqi gmldphqtlf gphesgqcwn
      241 lkddskeise lsdqfapfvg ifgstketfi ngnfpgtffr fplrlqpsql ssnlynkqkv
      301 lelfesfrad adtvllflks vqdvslyvre adgteklvfr vtsseskalk herpnsikil
      361 gtaisnyckk tpsnnitcvt yhvnivleee stkdaqktsw lvcnsvggrg isskldslad
      421 elkfvpiigi amplssrdde akgatsdfsg kafcflplpp geesstglpv hisgffgltd
      481 nrrsikwrel dqwrdpaalw neflvmnvvp kayatlilds ikrlemekss dfplsvdviy
      541 klwpeaskvk vhwqpvlepl fsellqnavi ysiscdwvrl eqvyfselde nleytktvln
      601 ylqssgkqia kvpgnvdaav qltaasgttp vrkvtpawvr qvlrkcahlg caeeklhlle
      661 fvlsdqayse llglellplq ngnfvpfsss vsdqdviyit saeyprslfp slegrfildn
      721 lkphlvaalk eaaqtrgrpc tqlqllnper farlikevmn tfwpgreliv qwypfdenrn
      781 hpsvswlkmv wknlyihfse dltlfdempl iprtileegq tcvelirlri pslvilddes
      841 eaqlpeflad ivqklggfvl kkldasiqhp likkyihspl psavlqimek mplqklcnqi
      901 tsllpthkda lrkflasltd ssekekriiq elaifkrinh ssdqgissyt klkgckvlhh
      961 taklpadlrl sisvidssde atirlanmlk ieqlkttscl klvlkdiena fysheevtql
     1021 mlwvlenlss lknenpnvle wltplkfiqi sqeqmvsage lfdpdievlk dlfcneegty
     1081 fppsvftspd ilhslrqigl kneaslkekd vvqvakkiea lqvgacpdqd vllkkaktll
     1141 lvlnknhtll qssegkmtlk kikwvpacke rppnypgslv wkgdlcnlca ppdmcdvgha
     1201 iligsslplv esihvnleka lgiftkpsls avlkhfkivv dwyssktfsd edyyqfqhil
     1261 leiygfmhdh lnegkdsfra lkfpwvwtgk kfcplaqavi kpihdldlqp ylhnvpktma
     1321 kfhqlfkvcg sieeltsdhi smviqkiylk sdqdlseqes kqnlhlmlni irwlysnqip
     1381 aspntpvpih hsknpsklim kpiheccycd ikvddlndll edsvepiilv hedipmktae
     1441 wlkvpclstr linpenmgfe qsgqrepltv riknileeyp svsdifkell qnaddanate
     1501 csflidmrrn mdirenlldp gmaachgpal wsfnnsqfsd sdfvnitrlg eslkrgevdk
     1561 vgkfglgfns vyhitdipii msrefmimfd pninhiskhi kdksnpgiki nwskqqkrlr
     1621 kfpnqfkpfi dvfgcqlplt veapysyngt lfrlsfrtqq eakvsevsst cyntadiysl
     1681 vdefslcghr liiftqsvks mylkylkiee tnpslaqdtv iikkkscssk alntpvlsvl
     1741 keaaklmktc sssnkklpsd epksscilqi tveefhhvfr riadlqsplf rgpdddpaal
     1801 femaksgqsk kpsdelsqkt vecttwllct cmdtgealkf slsesgrrlg lvpcgavgvq
     1861 lseiqdqkwt vkphigevfc ylplriktgl pvhingcfav tsnrkeiwkt dtkgrwnttf
     1921 mrhvivkayl qvlsvlrdla tsgelmdyty yavwpdpdlv hddfsvicqg fyediahgkg
     1981 keltkvfsdg stwvsmknvr flddsilkrr dvgsaafkif lkylkktgsk nlcavelpss
     2041 vklgfeeagc kqillentfs ekqffsevff pniqeieael rdplmifvln ekvdefsgvl
     2101 rvtpcipcsl eghplvlpsr lihpegrvak lfdikdgrfp ygstqdylnp iiliklvqlg
     2161 makddilwdd mleravsvae inksdhvaac lrssillsli deklkirdpr akdfaakyqt
     2221 irflpfltkp agfsldwkgn sfkpetmfaa tdlytaehqd ivcllqpiln enshsfrgcg
     2281 svslavkefl gllkkptvdl vinqlkevak svddgitlyq enitnacyky lhealmqnei
     2341 tkmsiidklk pfsfilvena yvdsekvsfh lnfeaapyly qlpnkyknnf relfetvgvr
     2401 qsctvedfal vlesidqerg tkqiteenfq lcrriisegi wslirekkqe fceknygkil
     2461 lpdtnlmllp akslcyndcp wikvkdttvk ychadiprev avklgavpkr hkaleryasn
     2521 vcfttlgtef gqkekltsri ksilnaypse kemlkellqn addakateic fvfdprqhpv
     2581 drifddkwap lqgpalcvyn nqpfteddvr giqnlgkgtk egnpyktgqy gigfnsvyhi
     2641 tdcpsfisgn dilcifdpha ryapgatsis pgrmfrdlda dfrtqfsdvl dlylgthfkl
     2701 dnctmfrfpl rnaemakvse issvpasdrm vqnlldklrs dgaellmfln hmekisicei
     2761 dkstgalnvl ysvkgkitdg drlkrkqfha svidsvtkkr qlkdipvqqi tytmdtedse
     2821 gnlttwlicn rsgfssmekv sksvisahkn qditlfprgg vaacithnyk kphrafcflp
     2881 lsletglpfh vnghfaldsa rrnlwrddng vgvrsdwnns lmtaliapay velliqlkkr
     2941 yfpgsdptls vlqntpihvv kdtlkkflsf fpvnrldlqp dlyclvkaly ncihedmkrl
     3001 lpvvrapnid gsdlhsavii twinmstsnk trpffdnllq delqhlknad ynittrktva
     3061 envyrlkhll leigfnlvyn cdetanlyhc lidadipvsy vtpadirsfl mtfsspdtnc
     3121 higklpcrlq qtnlklfhsl kllvdycfkd aeeneieveg lpllitldsv lqtfdakrpk
     3181 flttyhelip srkdlfmntl ylkysnilln ckvakvfdis sfadllssvl preyktksct
     3241 kwkdnfases wlknawhfis esvsvkedqe etkptfdivv dtlkdwallp gtkftvsanq
     3301 lvvpegdvll plslmhiavf pnaqsdkvfh almkagciql alnkicskds afvpllscht
     3361 aniesptsil kalhymvqts tfraeklven dfeallmyfn cnlnhlmsqd dikilkslpc
     3421 yksisgryvs igkfgtcyvl tksipsaeve kwtqssssaf leekihlkel yevigcvpvd
     3481 dlevylkhll pkienlsyda klehliylkn rlssaeelse ikeqlfekle slliihdans
     3541 rlkqakhfyd rtvrvfevml peklfipndf fkkleqlikp knhvtfmtsw veflrniglk
     3601 yilsqqqllq fakeisvran tenwsketlq ntvdillhhi fqermdllsg nflkelslip
     3661 flcperapae firfhpqyqe vngtlplikf ngaqvnpkfk qcdvlqllwt scpilpekat
     3721 plsikeqegs dlgpqeqleq vlnmlnvnld ppldkvinnc rnicnittld eemvktrakv
     3781 lrsiyeflsa ekrefrfqlr gvafvmvedg wkllkpeevv inleyesdfk pylyklplel
     3841 gtfhqlfkhl gtediistkq yvevlsrifk nsegkqldpn emrtvkrvvs glfrslqnds
     3901 vkvrsdlenv rdlalylpsq dgrlvkssil vfddaphyks riqgnigvqm lvdlsqcylg
     3961 kdhgfhtkli mlfpqklrpr llssileeql deetpkvcqf galcslqgrl qlllsseqfi
     4021 tglirimkhe ndnaflanee kairlckalr eglkvscfek lqttlrvkgf npiphsrset
     4081 faflkrfgna villyiqhsd skdinfllal amtlksatdn lisdtsylia mlgcndiyri
     4141 gekldslgvk ydssepskle lpmpgtpipa eihytllmdp mnvfypgeyv gylvdaeggd
     4201 iygsyqptyt yaiivqever edadnssflg kiyqidigys eykivssldl ykfsrpeess
     4261 qsrdsapstp tsptefltpg lrsipplfsg reshktsskh qspkklkvns lpeilkevts
     4321 vveqawklpe serkkiirrl ylkwhpdknp enhdianevf khlqneinrl ekqafldqna
     4381 drasrrtfst sasrfqsdky sfqrfytswn qeatshkser qqqnkekcpp sagqtysqrf
     4441 fvpptfksvg npvearrwlr qaranfsaar ndlhknanew vcfkcylstk laliaadyav
     4501 rgksdkdvkp talaqkieey sqqlegltnd vhtleaygvd slktrypdll pfpqipndrf
     4561 tsevamrvme ctaciiikle nfmqqkv
//
LOCUS       XP_011533341            4585 aa            linear   PRI 05-AUG-2025
DEFINITION  sacsin isoform X4 [Homo sapiens].
ACCESSION   XP_011533341
VERSION     XP_011533341.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535039.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4585
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..4585
                     /product="sacsin isoform X4"
                     /calculated_mol_wt=521774
     Region          4..75
                     /region_name="Ubl_Sacsin"
                     /note="ubiquitin-like (Ubl) domain found in Sacsin and
                     similar proteins; cd17049"
                     /db_xref="CDD:340569"
     Region          <4328..>4363
                     /region_name="DnaJ"
                     /note="DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock
                     protein 40) proteins are highly conserved and play crucial
                     roles in protein translation, folding, unfolding,
                     translocation, and degradation. They act primarily by
                     stimulating the ATPase activity of Hsp70s; cl02542"
                     /db_xref="CDD:413365"
     Region          4457..4573
                     /region_name="HEPN"
                     /note="Higher Eukarytoes and Prokaryotes
                     Nucleotide-binding domain; smart00748"
                     /db_xref="CDD:214800"
     CDS             1..4585
                     /gene="SACS"
                     /gene_synonym="ARSACS; DNAJC29; PPP1R138; SPAX6"
                     /coded_by="XM_011535039.3:147..13904"
                     /db_xref="GeneID:26278"
                     /db_xref="HGNC:HGNC:10519"
                     /db_xref="MIM:604490"
ORIGIN      
        1 mwerwvpvtv lpgcvgcrtv aalaswtvrd vkerifaetg fpvseqrlwr ggrelsdwik
       61 igdltsknch lfvnlqskgl kgggrfgqtt pplvdflkdi lrrypeggqi lkeliqnaed
      121 agatevkfly detqygtetl wskdmapyqg palyvynnav ftpedwhgiq eiarsrkkdd
      181 plkvgrfgig fnsvyhitdv pcifsgdqig mldphqtlfg phesgqcwnl kddskeisel
      241 sdqfapfvgi fgstketfin gnfpgtffrf plrlqpsqls snlynkqkvl elfesfrada
      301 dtvllflksv qdvslyvrea dgteklvfrv tsseskalkh erpnsikilg taisnyckkt
      361 psnnitcvty hvnivleees tkdaqktswl vcnsvggrgi sskldslade lkfvpiigia
      421 mplssrddea kgatsdfsgk afcflplppg eesstglpvh isgffgltdn rrsikwreld
      481 qwrdpaalwn eflvmnvvpk ayatlildsi krlemekssd fplsvdviyk lwpeaskvkv
      541 hwqpvleplf sellqnaviy siscdwvrle qvyfselden leytktvlny lqssgkqiak
      601 vpgnvdaavq ltaasgttpv rkvtpawvrq vlrkcahlgc aeeklhllef vlsdqaysel
      661 lglellplqn gnfvpfsssv sdqdviyits aeyprslfps legrfildnl kphlvaalke
      721 aaqtraqqql wgysgrpctq lqllnperfa rlikevmntf wpgrelivqw ypfdenrnhp
      781 svswlkmvwk nlyihfsedl tlfdemplip rtileegqtc velirlrips lvilddesea
      841 qlpefladiv qklggfvlkk ldasiqhpli kkyihsplps avlqimekmp lqklcnqits
      901 llpthkdalr kflasltdss ekekriiqel aifkrinhss dqgissytkl kgckvlhhta
      961 klpadlrlsi svidssdeat irlanmlkie qlkttsclkl vlkdienafy sheevtqlml
     1021 wvlenlsslk nenpnvlewl tplkfiqisq eqmvsagelf dpdievlkdl fcneegtyfp
     1081 psvftspdil hslrqiglkn easlkekdvv qvakkiealq vgacpdqdvl lkkaktlllv
     1141 lnknhtllqs segkmtlkki kwvpackerp pnypgslvwk gdlcnlcapp dmcdvghail
     1201 igsslplves ihvnlekalg iftkpslsav lkhfkivvdw yssktfsded yyqfqhille
     1261 iygfmhdhln egkdsfralk fpwvwtgkkf cplaqavikp ihdldlqpyl hnvpktmakf
     1321 hqlfkvcgsi eeltsdhism viqkiylksd qdlseqeskq nlhlmlniir wlysnqipas
     1381 pntpvpihhs knpsklimkp iheccycdik vddlndlled svepiilvhe dipmktaewl
     1441 kvpclstrli npenmgfeqs gqrepltvri knileeypsv sdifkellqn addanatecs
     1501 flidmrrnmd irenlldpgm aachgpalws fnnsqfsdsd fvnitrlges lkrgevdkvg
     1561 kfglgfnsvy hitdipiims refmimfdpn inhiskhikd ksnpgikinw skqqkrlrkf
     1621 pnqfkpfidv fgcqlpltve apysyngtlf rlsfrtqqea kvsevsstcy ntadiyslvd
     1681 efslcghrli iftqsvksmy lkylkieetn pslaqdtvii kkkscsskal ntpvlsvlke
     1741 aaklmktcss snkklpsdep ksscilqitv eefhhvfrri adlqsplfrg pdddpaalfe
     1801 maksgqskkp sdelsqktve cttwllctcm dtgealkfsl sesgrrlglv pcgavgvqls
     1861 eiqdqkwtvk phigevfcyl plriktglpv hingcfavts nrkeiwktdt kgrwnttfmr
     1921 hvivkaylqv lsvlrdlats gelmdytyya vwpdpdlvhd dfsvicqgfy ediahgkgke
     1981 ltkvfsdgst wvsmknvrfl ddsilkrrdv gsaafkiflk ylkktgsknl cavelpssvk
     2041 lgfeeagckq illentfsek qffsevffpn iqeieaelrd plmifvlnek vdefsgvlrv
     2101 tpcipcsleg hplvlpsrli hpegrvaklf dikdgrfpyg stqdylnpii liklvqlgma
     2161 kddilwddml eravsvaein ksdhvaaclr ssillslide klkirdprak dfaakyqtir
     2221 flpfltkpag fsldwkgnsf kpetmfaatd lytaehqdiv cllqpilnen shsfrgcgsv
     2281 slavkeflgl lkkptvdlvi nqlkevaksv ddgitlyqen itnacykylh ealmqneitk
     2341 msiidklkpf sfilvenayv dsekvsfhln feaapylyql pnkyknnfre lfetvgvrqs
     2401 ctvedfalvl esidqergtk qiteenfqlc rriisegiws lirekkqefc eknygkillp
     2461 dtnlmllpak slcyndcpwi kvkdttvkyc hadiprevav klgavpkrhk aleryasnvc
     2521 fttlgtefgq kekltsriks ilnaypseke mlkellqnad dakateicfv fdprqhpvdr
     2581 ifddkwaplq gpalcvynnq pfteddvrgi qnlgkgtkeg npyktgqygi gfnsvyhitd
     2641 cpsfisgndi lcifdphary apgatsispg rmfrdldadf rtqfsdvldl ylgthfkldn
     2701 ctmfrfplrn aemakvseis svpasdrmvq nlldklrsdg aellmflnhm ekisiceidk
     2761 stgalnvlys vkgkitdgdr lkrkqfhasv idsvtkkrql kdipvqqity tmdtedsegn
     2821 lttwlicnrs gfssmekvsk svisahknqd itlfprggva acithnykkp hrafcflpls
     2881 letglpfhvn ghfaldsarr nlwrddngvg vrsdwnnslm taliapayve lliqlkkryf
     2941 pgsdptlsvl qntpihvvkd tlkkflsffp vnrldlqpdl yclvkalync ihedmkrllp
     3001 vvrapnidgs dlhsaviitw inmstsnktr pffdnllqde lqhlknadyn ittrktvaen
     3061 vyrlkhllle igfnlvyncd etanlyhcli dadipvsyvt padirsflmt fsspdtnchi
     3121 gklpcrlqqt nlklfhslkl lvdycfkdae eneieveglp llitldsvlq tfdakrpkfl
     3181 ttyhelipsr kdlfmntlyl kysnillnck vakvfdissf adllssvlpr eyktksctkw
     3241 kdnfaseswl knawhfises vsvkedqeet kptfdivvdt lkdwallpgt kftvsanqlv
     3301 vpegdvllpl slmhiavfpn aqsdkvfhal mkagciqlal nkicskdsaf vpllschtan
     3361 iesptsilka lhymvqtstf raeklvendf eallmyfncn lnhlmsqddi kilkslpcyk
     3421 sisgryvsig kfgtcyvltk sipsaevekw tqssssafle ekihlkelye vigcvpvddl
     3481 evylkhllpk ienlsydakl ehliylknrl ssaeelseik eqlfeklesl liihdansrl
     3541 kqakhfydrt vrvfevmlpe klfipndffk kleqlikpkn hvtfmtswve flrniglkyi
     3601 lsqqqllqfa keisvrante nwsketlqnt vdillhhifq ermdllsgnf lkelslipfl
     3661 cperapaefi rfhpqyqevn gtlplikfng aqvnpkfkqc dvlqllwtsc pilpekatpl
     3721 sikeqegsdl gpqeqleqvl nmlnvnldpp ldkvinncrn icnittldee mvktrakvlr
     3781 siyeflsaek refrfqlrgv afvmvedgwk llkpeevvin leyesdfkpy lyklplelgt
     3841 fhqlfkhlgt ediistkqyv evlsrifkns egkqldpnem rtvkrvvsgl frslqndsvk
     3901 vrsdlenvrd lalylpsqdg rlvkssilvf ddaphyksri qgnigvqmlv dlsqcylgkd
     3961 hgfhtkliml fpqklrprll ssileeqlde etpkvcqfga lcslqgrlql llsseqfitg
     4021 lirimkhend naflaneeka irlckalreg lkvscfeklq ttlrvkgfnp iphsrsetfa
     4081 flkrfgnavi llyiqhsdsk dinfllalam tlksatdnli sdtsyliaml gcndiyrige
     4141 kldslgvkyd ssepsklelp mpgtpipaei hytllmdpmn vfypgeyvgy lvdaeggdiy
     4201 gsyqptytya iivqevered adnssflgki yqidigysey kivssldlyk fsrpeessqs
     4261 rdsapstpts ptefltpglr sipplfsgre shktsskhqs pkklkvnslp eilkevtsvv
     4321 eqawklpese rkkiirrlyl kwhpdknpen hdianevfkh lqneinrlek qafldqnadr
     4381 asrrtfstsa srfqsdkysf qrfytswnqe atshkserqq qnkekcppsa gqtysqrffv
     4441 pptfksvgnp vearrwlrqa ranfsaarnd lhknanewvc fkcylstkla liaadyavrg
     4501 ksdkdvkpta laqkieeysq qlegltndvh tleaygvdsl ktrypdllpf pqipndrfts
     4561 evamrvmect aciiiklenf mqqkv
//
LOCUS       XP_047286212            4579 aa            linear   PRI 05-AUG-2025
DEFINITION  sacsin isoform X5 [Homo sapiens].
ACCESSION   XP_047286212
VERSION     XP_047286212.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430256.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4579
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..4579
                     /product="sacsin isoform X5"
                     /calculated_mol_wt=520998
     Region          7..78
                     /region_name="Ubl_Sacsin"
                     /note="ubiquitin-like (Ubl) domain found in Sacsin and
                     similar proteins; cd17049"
                     /db_xref="CDD:340569"
     Region          <4322..>4357
                     /region_name="DnaJ"
                     /note="DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock
                     protein 40) proteins are highly conserved and play crucial
                     roles in protein translation, folding, unfolding,
                     translocation, and degradation. They act primarily by
                     stimulating the ATPase activity of Hsp70s; cl02542"
                     /db_xref="CDD:413365"
     Region          4451..4567
                     /region_name="HEPN"
                     /note="Higher Eukarytoes and Prokaryotes
                     Nucleotide-binding domain; smart00748"
                     /db_xref="CDD:214800"
     CDS             1..4579
                     /gene="SACS"
                     /gene_synonym="ARSACS; DNAJC29; PPP1R138; SPAX6"
                     /coded_by="XM_047430256.1:811..14550"
                     /db_xref="GeneID:26278"
                     /db_xref="HGNC:HGNC:10519"
                     /db_xref="MIM:604490"
ORIGIN      
        1 metkenrwvp vtvlpgcvgc rtvaalaswt vrdvkerifa etgfpvseqr lwrggrelsd
       61 wikigdltsk nchlfvnlqs kglkgggrfg qttpplvdfl kdilrrypeg gqilkeliqn
      121 aedagatevk flydetqygt etlwskdmap yqgpalyvyn navftpedwh giqeiarsrk
      181 kddplkvgrf gigfnsvyhi tdvpcifsgd qigmldphqt lfgphesgqc wnlkddskei
      241 selsdqfapf vgifgstket fingnfpgtf frfplrlqps qlssnlynkq kvlelfesfr
      301 adadtvllfl ksvqdvslyv readgteklv frvtsseska lkherpnsik ilgtaisnyc
      361 kktpsnnitc vtyhvnivle eestkdaqkt swlvcnsvgg rgisskldsl adelkfvpii
      421 giamplssrd deakgatsdf sgkafcflpl ppgeesstgl pvhisgffgl tdnrrsikwr
      481 eldqwrdpaa lwneflvmnv vpkayatlil dsikrlemek ssdfplsvdv iyklwpeask
      541 vkvhwqpvle plfsellqna viysiscdwv rleqvyfsel denleytktv lnylqssgkq
      601 iakvpgnvda avqltaasgt tpvrkvtpaw vrqvlrkcah lgcaeeklhl lefvlsdqay
      661 sellglellp lqngnfvpfs ssvsdqdviy itsaeyprsl fpslegrfil dnlkphlvaa
      721 lkeaaqtrgr pctqlqllnp erfarlikev mntfwpgrel ivqwypfden rnhpsvswlk
      781 mvwknlyihf sedltlfdem pliprtilee gqtcvelirl ripslvildd eseaqlpefl
      841 adivqklggf vlkkldasiq hplikkyihs plpsavlqim ekmplqklcn qitsllpthk
      901 dalrkflasl tdssekekri iqelaifkri nhssdqgiss ytklkgckvl hhtaklpadl
      961 rlsisvidss deatirlanm lkieqlktts clklvlkdie nafysheevt qlmlwvlenl
     1021 sslknenpnv lewltplkfi qisqeqmvsa gelfdpdiev lkdlfcneeg tyfppsvfts
     1081 pdilhslrqi glkneaslke kdvvqvakki ealqvgacpd qdvllkkakt lllvlnknht
     1141 llqssegkmt lkkikwvpac kerppnypgs lvwkgdlcnl cappdmcdvg hailigsslp
     1201 lvesihvnle kalgiftkps lsavlkhfki vvdwyssktf sdedyyqfqh illeiygfmh
     1261 dhlnegkdsf ralkfpwvwt gkkfcplaqa vikpihdldl qpylhnvpkt makfhqlfkv
     1321 cgsieeltsd hismviqkiy lksdqdlseq eskqnlhlml niirwlysnq ipaspntpvp
     1381 ihhsknpskl imkpiheccy cdikvddlnd lledsvepii lvhedipmkt aewlkvpcls
     1441 trlinpenmg feqsgqrepl tvriknilee ypsvsdifke llqnaddana tecsflidmr
     1501 rnmdirenll dpgmaachgp alwsfnnsqf sdsdfvnitr lgeslkrgev dkvgkfglgf
     1561 nsvyhitdip iimsrefmim fdpninhisk hikdksnpgi kinwskqqkr lrkfpnqfkp
     1621 fidvfgcqlp ltveapysyn gtlfrlsfrt qqeakvsevs stcyntadiy slvdefslcg
     1681 hrliiftqsv ksmylkylki eetnpslaqd tviikkkscs skalntpvls vlkeaaklmk
     1741 tcsssnkklp sdepksscil qitveefhhv frriadlqsp lfrgpdddpa alfemaksgq
     1801 skkpsdelsq ktvecttwll ctcmdtgeal kfslsesgrr lglvpcgavg vqlseiqdqk
     1861 wtvkphigev fcylplrikt glpvhingcf avtsnrkeiw ktdtkgrwnt tfmrhvivka
     1921 ylqvlsvlrd latsgelmdy tyyavwpdpd lvhddfsvic qgfyediahg kgkeltkvfs
     1981 dgstwvsmkn vrflddsilk rrdvgsaafk iflkylkktg sknlcavelp ssvklgfeea
     2041 gckqillent fsekqffsev ffpniqeiea elrdplmifv lnekvdefsg vlrvtpcipc
     2101 sleghplvlp srlihpegrv aklfdikdgr fpygstqdyl npiiliklvq lgmakddilw
     2161 ddmleravsv aeinksdhva aclrssills lideklkird prakdfaaky qtirflpflt
     2221 kpagfsldwk gnsfkpetmf aatdlytaeh qdivcllqpi lnenshsfrg cgsvslavke
     2281 flgllkkptv dlvinqlkev aksvddgitl yqenitnacy kylhealmqn eitkmsiidk
     2341 lkpfsfilve nayvdsekvs fhlnfeaapy lyqlpnkykn nfrelfetvg vrqsctvedf
     2401 alvlesidqe rgtkqiteen fqlcrriise giwslirekk qefceknygk illpdtnlml
     2461 lpakslcynd cpwikvkdtt vkychadipr evavklgavp krhkalerya snvcfttlgt
     2521 efgqkeklts riksilnayp sekemlkell qnaddakate icfvfdprqh pvdrifddkw
     2581 aplqgpalcv ynnqpftedd vrgiqnlgkg tkegnpyktg qygigfnsvy hitdcpsfis
     2641 gndilcifdp haryapgats ispgrmfrdl dadfrtqfsd vldlylgthf kldnctmfrf
     2701 plrnaemakv seissvpasd rmvqnlldkl rsdgaellmf lnhmekisic eidkstgaln
     2761 vlysvkgkit dgdrlkrkqf hasvidsvtk krqlkdipvq qitytmdted segnlttwli
     2821 cnrsgfssme kvsksvisah knqditlfpr ggvaacithn ykkphrafcf lplsletglp
     2881 fhvnghfald sarrnlwrdd ngvgvrsdwn nslmtaliap ayvelliqlk kryfpgsdpt
     2941 lsvlqntpih vvkdtlkkfl sffpvnrldl qpdlyclvka lyncihedmk rllpvvrapn
     3001 idgsdlhsav iitwinmsts nktrpffdnl lqdelqhlkn adynittrkt vaenvyrlkh
     3061 llleigfnlv yncdetanly hclidadipv syvtpadirs flmtfsspdt nchigklpcr
     3121 lqqtnlklfh slkllvdycf kdaeeneiev eglpllitld svlqtfdakr pkflttyhel
     3181 ipsrkdlfmn tlylkysnil lnckvakvfd issfadllss vlpreyktks ctkwkdnfas
     3241 eswlknawhf isesvsvked qeetkptfdi vvdtlkdwal lpgtkftvsa nqlvvpegdv
     3301 llplslmhia vfpnaqsdkv fhalmkagci qlalnkicsk dsafvpllsc htaniespts
     3361 ilkalhymvq tstfraeklv endfeallmy fncnlnhlms qddikilksl pcyksisgry
     3421 vsigkfgtcy vltksipsae vekwtqssss afleekihlk elyevigcvp vddlevylkh
     3481 llpkienlsy daklehliyl knrlssaeel seikeqlfek leslliihda nsrlkqakhf
     3541 ydrtvrvfev mlpeklfipn dffkkleqli kpknhvtfmt swveflrnig lkyilsqqql
     3601 lqfakeisvr antenwsket lqntvdillh hifqermdll sgnflkelsl ipflcperap
     3661 aefirfhpqy qevngtlpli kfngaqvnpk fkqcdvlqll wtscpilpek atplsikeqe
     3721 gsdlgpqeql eqvlnmlnvn ldppldkvin ncrnicnitt ldeemvktra kvlrsiyefl
     3781 saekrefrfq lrgvafvmve dgwkllkpee vvinleyesd fkpylyklpl elgtfhqlfk
     3841 hlgtediist kqyvevlsri fknsegkqld pnemrtvkrv vsglfrslqn dsvkvrsdle
     3901 nvrdlalylp sqdgrlvkss ilvfddaphy ksriqgnigv qmlvdlsqcy lgkdhgfhtk
     3961 limlfpqklr prllssilee qldeetpkvc qfgalcslqg rlqlllsseq fitglirimk
     4021 hendnaflan eekairlcka lreglkvscf eklqttlrvk gfnpiphsrs etfaflkrfg
     4081 navillyiqh sdskdinfll alamtlksat dnlisdtsyl iamlgcndiy rigekldslg
     4141 vkydssepsk lelpmpgtpi paeihytllm dpmnvfypge yvgylvdaeg gdiygsyqpt
     4201 ytyaiivqev eredadnssf lgkiyqidig yseykivssl dlykfsrpee ssqsrdsaps
     4261 tptspteflt pglrsipplf sgreshktss khqspkklkv nslpeilkev tsvveqawkl
     4321 peserkkiir rlylkwhpdk npenhdiane vfkhlqnein rlekqafldq nadrasrrtf
     4381 stsasrfqsd kysfqrfyts wnqeatshks erqqqnkekc ppsagqtysq rffvpptfks
     4441 vgnpvearrw lrqaranfsa arndlhknan ewvcfkcyls tklaliaady avrgksdkdv
     4501 kptalaqkie eysqqleglt ndvhtleayg vdslktrypd llpfpqipnd rftsevamrv
     4561 mectaciiik lenfmqqkv
//
LOCUS       XP_016876028            4576 aa            linear   PRI 05-AUG-2025
DEFINITION  sacsin isoform X6 [Homo sapiens].
ACCESSION   XP_016876028
VERSION     XP_016876028.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020539.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4576
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..4576
                     /product="sacsin isoform X6"
                     /calculated_mol_wt=520711
     Region          4..75
                     /region_name="Ubl_Sacsin"
                     /note="ubiquitin-like (Ubl) domain found in Sacsin and
                     similar proteins; cd17049"
                     /db_xref="CDD:340569"
     Region          <4319..>4354
                     /region_name="DnaJ"
                     /note="DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock
                     protein 40) proteins are highly conserved and play crucial
                     roles in protein translation, folding, unfolding,
                     translocation, and degradation. They act primarily by
                     stimulating the ATPase activity of Hsp70s; cl02542"
                     /db_xref="CDD:413365"
     Region          4448..4564
                     /region_name="HEPN"
                     /note="Higher Eukarytoes and Prokaryotes
                     Nucleotide-binding domain; smart00748"
                     /db_xref="CDD:214800"
     CDS             1..4576
                     /gene="SACS"
                     /gene_synonym="ARSACS; DNAJC29; PPP1R138; SPAX6"
                     /coded_by="XM_017020539.2:147..13877"
                     /db_xref="GeneID:26278"
                     /db_xref="HGNC:HGNC:10519"
                     /db_xref="MIM:604490"
ORIGIN      
        1 mwerwvpvtv lpgcvgcrtv aalaswtvrd vkerifaetg fpvseqrlwr ggrelsdwik
       61 igdltsknch lfvnlqskgl kgggrfgqtt pplvdflkdi lrrypeggqi lkeliqnaed
      121 agatevkfly detqygtetl wskdmapyqg palyvynnav ftpedwhgiq eiarsrkkdd
      181 plkvgrfgig fnsvyhitdv pcifsgdqig mldphqtlfg phesgqcwnl kddskeisel
      241 sdqfapfvgi fgstketfin gnfpgtffrf plrlqpsqls snlynkqkvl elfesfrada
      301 dtvllflksv qdvslyvrea dgteklvfrv tsseskalkh erpnsikilg taisnyckkt
      361 psnnitcvty hvnivleees tkdaqktswl vcnsvggrgi sskldslade lkfvpiigia
      421 mplssrddea kgatsdfsgk afcflplppg eesstglpvh isgffgltdn rrsikwreld
      481 qwrdpaalwn eflvmnvvpk ayatlildsi krlemekssd fplsvdviyk lwpeaskvkv
      541 hwqpvleplf sellqnaviy siscdwvrle qvyfselden leytktvlny lqssgkqiak
      601 vpgnvdaavq ltaasgttpv rkvtpawvrq vlrkcahlgc aeeklhllef vlsdqaysel
      661 lglellplqn gnfvpfsssv sdqdviyits aeyprslfps legrfildnl kphlvaalke
      721 aaqtrgrpct qlqllnperf arlikevmnt fwpgrelivq wypfdenrnh psvswlkmvw
      781 knlyihfsed ltlfdempli prtileegqt cvelirlrip slvilddese aqlpefladi
      841 vqklggfvlk kldasiqhpl ikkyihsplp savlqimekm plqklcnqit sllpthkdal
      901 rkflasltds sekekriiqe laifkrinhs sdqgissytk lkgckvlhht aklpadlrls
      961 isvidssdea tirlanmlki eqlkttsclk lvlkdienaf ysheevtqlm lwvlenlssl
     1021 knenpnvlew ltplkfiqis qeqmvsagel fdpdievlkd lfcneegtyf ppsvftspdi
     1081 lhslrqiglk neaslkekdv vqvakkieal qvgacpdqdv llkkaktlll vlnknhtllq
     1141 ssegkmtlkk ikwvpacker ppnypgslvw kgdlcnlcap pdmcdvghai ligsslplve
     1201 sihvnlekal giftkpslsa vlkhfkivvd wyssktfsde dyyqfqhill eiygfmhdhl
     1261 negkdsfral kfpwvwtgkk fcplaqavik pihdldlqpy lhnvpktmak fhqlfkvcgs
     1321 ieeltsdhis mviqkiylks dqdlseqesk qnlhlmlnii rwlysnqipa spntpvpihh
     1381 sknpsklimk piheccycdi kvddlndlle dsvepiilvh edipmktaew lkvpclstrl
     1441 inpenmgfeq sgqrepltvr iknileeyps vsdifkellq naddanatec sflidmrrnm
     1501 direnlldpg maachgpalw sfnnsqfsds dfvnitrlge slkrgevdkv gkfglgfnsv
     1561 yhitdipiim srefmimfdp ninhiskhik dksnpgikin wskqqkrlrk fpnqfkpfid
     1621 vfgcqlpltv eapysyngtl frlsfrtqqe akvsevsstc yntadiyslv defslcghrl
     1681 iiftqsvksm ylkylkieet npslaqdtvi ikkkscsska lntpvlsvlk eaaklmktcs
     1741 ssnkklpsde pksscilqit veefhhvfrr iadlqsplfr gpdddpaalf emaksgqskk
     1801 psdelsqktv ecttwllctc mdtgealkfs lsesgrrlgl vpcgavgvql seiqdqkwtv
     1861 kphigevfcy lplriktglp vhingcfavt snrkeiwktd tkgrwnttfm rhvivkaylq
     1921 vlsvlrdlat sgelmdytyy avwpdpdlvh ddfsvicqgf yediahgkgk eltkvfsdgs
     1981 twvsmknvrf lddsilkrrd vgsaafkifl kylkktgskn lcavelpssv klgfeeagck
     2041 qillentfse kqffsevffp niqeieaelr dplmifvlne kvdefsgvlr vtpcipcsle
     2101 ghplvlpsrl ihpegrvakl fdikdgrfpy gstqdylnpi iliklvqlgm akddilwddm
     2161 leravsvaei nksdhvaacl rssillslid eklkirdpra kdfaakyqti rflpfltkpa
     2221 gfsldwkgns fkpetmfaat dlytaehqdi vcllqpilne nshsfrgcgs vslavkeflg
     2281 llkkptvdlv inqlkevaks vddgitlyqe nitnacykyl healmqneit kmsiidklkp
     2341 fsfilvenay vdsekvsfhl nfeaapylyq lpnkyknnfr elfetvgvrq sctvedfalv
     2401 lesidqergt kqiteenfql crriisegiw slirekkqef ceknygkill pdtnlmllpa
     2461 kslcyndcpw ikvkdttvky chadipreva vklgavpkrh kaleryasnv cfttlgtefg
     2521 qkekltsrik silnaypsek emlkellqna ddakateicf vfdprqhpvd rifddkwapl
     2581 qgpalcvynn qpfteddvrg iqnlgkgtke gnpyktgqyg igfnsvyhit dcpsfisgnd
     2641 ilcifdphar yapgatsisp grmfrdldad frtqfsdvld lylgthfkld nctmfrfplr
     2701 naemakvsei ssvpasdrmv qnlldklrsd gaellmflnh mekisiceid kstgalnvly
     2761 svkgkitdgd rlkrkqfhas vidsvtkkrq lkdipvqqit ytmdtedseg nlttwlicnr
     2821 sgfssmekvs ksvisahknq ditlfprggv aacithnykk phrafcflpl sletglpfhv
     2881 nghfaldsar rnlwrddngv gvrsdwnnsl mtaliapayv elliqlkkry fpgsdptlsv
     2941 lqntpihvvk dtlkkflsff pvnrldlqpd lyclvkalyn cihedmkrll pvvrapnidg
     3001 sdlhsaviit winmstsnkt rpffdnllqd elqhlknady nittrktvae nvyrlkhlll
     3061 eigfnlvync detanlyhcl idadipvsyv tpadirsflm tfsspdtnch igklpcrlqq
     3121 tnlklfhslk llvdycfkda eeneievegl pllitldsvl qtfdakrpkf lttyhelips
     3181 rkdlfmntly lkysnillnc kvakvfdiss fadllssvlp reyktksctk wkdnfasesw
     3241 lknawhfise svsvkedqee tkptfdivvd tlkdwallpg tkftvsanql vvpegdvllp
     3301 lslmhiavfp naqsdkvfha lmkagciqla lnkicskdsa fvpllschta niesptsilk
     3361 alhymvqtst fraeklvend feallmyfnc nlnhlmsqdd ikilkslpcy ksisgryvsi
     3421 gkfgtcyvlt ksipsaevek wtqssssafl eekihlkely evigcvpvdd levylkhllp
     3481 kienlsydak lehliylknr lssaeelsei keqlfekles lliihdansr lkqakhfydr
     3541 tvrvfevmlp eklfipndff kkleqlikpk nhvtfmtswv eflrniglky ilsqqqllqf
     3601 akeisvrant enwsketlqn tvdillhhif qermdllsgn flkelslipf lcperapaef
     3661 irfhpqyqev ngtlplikfn gaqvnpkfkq cdvlqllwts cpilpekatp lsikeqegsd
     3721 lgpqeqleqv lnmlnvnldp pldkvinncr nicnittlde emvktrakvl rsiyeflsae
     3781 krefrfqlrg vafvmvedgw kllkpeevvi nleyesdfkp ylyklplelg tfhqlfkhlg
     3841 tediistkqy vevlsrifkn segkqldpne mrtvkrvvsg lfrslqndsv kvrsdlenvr
     3901 dlalylpsqd grlvkssilv fddaphyksr iqgnigvqml vdlsqcylgk dhgfhtklim
     3961 lfpqklrprl lssileeqld eetpkvcqfg alcslqgrlq lllsseqfit glirimkhen
     4021 dnaflaneek airlckalre glkvscfekl qttlrvkgfn piphsrsetf aflkrfgnav
     4081 illyiqhsds kdinfllala mtlksatdnl isdtsyliam lgcndiyrig ekldslgvky
     4141 dssepsklel pmpgtpipae ihytllmdpm nvfypgeyvg ylvdaeggdi ygsyqptyty
     4201 aiivqevere dadnssflgk iyqidigyse ykivssldly kfsrpeessq srdsapstpt
     4261 sptefltpgl rsipplfsgr eshktsskhq spkklkvnsl peilkevtsv veqawklpes
     4321 erkkiirrly lkwhpdknpe nhdianevfk hlqneinrle kqafldqnad rasrrtfsts
     4381 asrfqsdkys fqrfytswnq eatshkserq qqnkekcpps agqtysqrff vpptfksvgn
     4441 pvearrwlrq aranfsaarn dlhknanewv cfkcylstkl aliaadyavr gksdkdvkpt
     4501 alaqkieeys qqlegltndv htleaygvds lktrypdllp fpqipndrft sevamrvmec
     4561 taciiiklen fmqqkv
//
LOCUS       XP_047286213            4539 aa            linear   PRI 05-AUG-2025
DEFINITION  sacsin isoform X7 [Homo sapiens].
ACCESSION   XP_047286213
VERSION     XP_047286213.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430257.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4539
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..4539
                     /product="sacsin isoform X7"
                     /calculated_mol_wt=516500
     Region          7..78
                     /region_name="Ubl_Sacsin"
                     /note="ubiquitin-like (Ubl) domain found in Sacsin and
                     similar proteins; cd17049"
                     /db_xref="CDD:340569"
     Region          <4282..>4317
                     /region_name="DnaJ"
                     /note="DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock
                     protein 40) proteins are highly conserved and play crucial
                     roles in protein translation, folding, unfolding,
                     translocation, and degradation. They act primarily by
                     stimulating the ATPase activity of Hsp70s; cl02542"
                     /db_xref="CDD:413365"
     Region          4411..4527
                     /region_name="HEPN"
                     /note="Higher Eukarytoes and Prokaryotes
                     Nucleotide-binding domain; smart00748"
                     /db_xref="CDD:214800"
     CDS             1..4539
                     /gene="SACS"
                     /gene_synonym="ARSACS; DNAJC29; PPP1R138; SPAX6"
                     /coded_by="XM_047430257.1:590..14209"
                     /db_xref="GeneID:26278"
                     /db_xref="HGNC:HGNC:10519"
                     /db_xref="MIM:604490"
ORIGIN      
        1 metkenrwvp vtvlpgcvgc rtvaalaswt vrdvkerifa etgfpvseqr lwrggrelsd
       61 wikigdltsk nchlfvnlqs kglkgggrfg qttpplvdfl kdilrrypeg gqilkeliqn
      121 aedagatevk flydetqygt etlwskdmap yqdvpcifsg dqigmldphq tlfgphesgq
      181 cwnlkddske iselsdqfap fvgifgstke tfingnfpgt ffrfplrlqp sqlssnlynk
      241 qkvlelfesf radadtvllf lksvqdvsly vreadgtekl vfrvtssesk alkherpnsi
      301 kilgtaisny ckktpsnnit cvtyhvnivl eeestkdaqk tswlvcnsvg grgissklds
      361 ladelkfvpi igiamplssr ddeakgatsd fsgkafcflp lppgeesstg lpvhisgffg
      421 ltdnrrsikw reldqwrdpa alwneflvmn vvpkayatli ldsikrleme kssdfplsvd
      481 viyklwpeas kvkvhwqpvl eplfsellqn aviysiscdw vrleqvyfse ldenleytkt
      541 vlnylqssgk qiakvpgnvd aavqltaasg ttpvrkvtpa wvrqvlrkca hlgcaeeklh
      601 llefvlsdqa ysellglell plqngnfvpf sssvsdqdvi yitsaeyprs lfpslegrfi
      661 ldnlkphlva alkeaaqtra qqqlwgysgr pctqlqllnp erfarlikev mntfwpgrel
      721 ivqwypfden rnhpsvswlk mvwknlyihf sedltlfdem pliprtilee gqtcvelirl
      781 ripslvildd eseaqlpefl adivqklggf vlkkldasiq hplikkyihs plpsavlqim
      841 ekmplqklcn qitsllpthk dalrkflasl tdssekekri iqelaifkri nhssdqgiss
      901 ytklkgckvl hhtaklpadl rlsisvidss deatirlanm lkieqlktts clklvlkdie
      961 nafysheevt qlmlwvlenl sslknenpnv lewltplkfi qisqeqmvsa gelfdpdiev
     1021 lkdlfcneeg tyfppsvfts pdilhslrqi glkneaslke kdvvqvakki ealqvgacpd
     1081 qdvllkkakt lllvlnknht llqssegkmt lkkikwvpac kerppnypgs lvwkgdlcnl
     1141 cappdmcdvg hailigsslp lvesihvnle kalgiftkps lsavlkhfki vvdwyssktf
     1201 sdedyyqfqh illeiygfmh dhlnegkdsf ralkfpwvwt gkkfcplaqa vikpihdldl
     1261 qpylhnvpkt makfhqlfkv cgsieeltsd hismviqkiy lksdqdlseq eskqnlhlml
     1321 niirwlysnq ipaspntpvp ihhsknpskl imkpiheccy cdikvddlnd lledsvepii
     1381 lvhedipmkt aewlkvpcls trlinpenmg feqsgqrepl tvriknilee ypsvsdifke
     1441 llqnaddana tecsflidmr rnmdirenll dpgmaachgp alwsfnnsqf sdsdfvnitr
     1501 lgeslkrgev dkvgkfglgf nsvyhitdip iimsrefmim fdpninhisk hikdksnpgi
     1561 kinwskqqkr lrkfpnqfkp fidvfgcqlp ltveapysyn gtlfrlsfrt qqeakvsevs
     1621 stcyntadiy slvdefslcg hrliiftqsv ksmylkylki eetnpslaqd tviikkkscs
     1681 skalntpvls vlkeaaklmk tcsssnkklp sdepksscil qitveefhhv frriadlqsp
     1741 lfrgpdddpa alfemaksgq skkpsdelsq ktvecttwll ctcmdtgeal kfslsesgrr
     1801 lglvpcgavg vqlseiqdqk wtvkphigev fcylplrikt glpvhingcf avtsnrkeiw
     1861 ktdtkgrwnt tfmrhvivka ylqvlsvlrd latsgelmdy tyyavwpdpd lvhddfsvic
     1921 qgfyediahg kgkeltkvfs dgstwvsmkn vrflddsilk rrdvgsaafk iflkylkktg
     1981 sknlcavelp ssvklgfeea gckqillent fsekqffsev ffpniqeiea elrdplmifv
     2041 lnekvdefsg vlrvtpcipc sleghplvlp srlihpegrv aklfdikdgr fpygstqdyl
     2101 npiiliklvq lgmakddilw ddmleravsv aeinksdhva aclrssills lideklkird
     2161 prakdfaaky qtirflpflt kpagfsldwk gnsfkpetmf aatdlytaeh qdivcllqpi
     2221 lnenshsfrg cgsvslavke flgllkkptv dlvinqlkev aksvddgitl yqenitnacy
     2281 kylhealmqn eitkmsiidk lkpfsfilve nayvdsekvs fhlnfeaapy lyqlpnkykn
     2341 nfrelfetvg vrqsctvedf alvlesidqe rgtkqiteen fqlcrriise giwslirekk
     2401 qefceknygk illpdtnlml lpakslcynd cpwikvkdtt vkychadipr evavklgavp
     2461 krhkalerya snvcfttlgt efgqkeklts riksilnayp sekemlkell qnaddakate
     2521 icfvfdprqh pvdrifddkw aplqgpalcv ynnqpftedd vrgiqnlgkg tkegnpyktg
     2581 qygigfnsvy hitdcpsfis gndilcifdp haryapgats ispgrmfrdl dadfrtqfsd
     2641 vldlylgthf kldnctmfrf plrnaemakv seissvpasd rmvqnlldkl rsdgaellmf
     2701 lnhmekisic eidkstgaln vlysvkgkit dgdrlkrkqf hasvidsvtk krqlkdipvq
     2761 qitytmdted segnlttwli cnrsgfssme kvsksvisah knqditlfpr ggvaacithn
     2821 ykkphrafcf lplsletglp fhvnghfald sarrnlwrdd ngvgvrsdwn nslmtaliap
     2881 ayvelliqlk kryfpgsdpt lsvlqntpih vvkdtlkkfl sffpvnrldl qpdlyclvka
     2941 lyncihedmk rllpvvrapn idgsdlhsav iitwinmsts nktrpffdnl lqdelqhlkn
     3001 adynittrkt vaenvyrlkh llleigfnlv yncdetanly hclidadipv syvtpadirs
     3061 flmtfsspdt nchigklpcr lqqtnlklfh slkllvdycf kdaeeneiev eglpllitld
     3121 svlqtfdakr pkflttyhel ipsrkdlfmn tlylkysnil lnckvakvfd issfadllss
     3181 vlpreyktks ctkwkdnfas eswlknawhf isesvsvked qeetkptfdi vvdtlkdwal
     3241 lpgtkftvsa nqlvvpegdv llplslmhia vfpnaqsdkv fhalmkagci qlalnkicsk
     3301 dsafvpllsc htaniespts ilkalhymvq tstfraeklv endfeallmy fncnlnhlms
     3361 qddikilksl pcyksisgry vsigkfgtcy vltksipsae vekwtqssss afleekihlk
     3421 elyevigcvp vddlevylkh llpkienlsy daklehliyl knrlssaeel seikeqlfek
     3481 leslliihda nsrlkqakhf ydrtvrvfev mlpeklfipn dffkkleqli kpknhvtfmt
     3541 swveflrnig lkyilsqqql lqfakeisvr antenwsket lqntvdillh hifqermdll
     3601 sgnflkelsl ipflcperap aefirfhpqy qevngtlpli kfngaqvnpk fkqcdvlqll
     3661 wtscpilpek atplsikeqe gsdlgpqeql eqvlnmlnvn ldppldkvin ncrnicnitt
     3721 ldeemvktra kvlrsiyefl saekrefrfq lrgvafvmve dgwkllkpee vvinleyesd
     3781 fkpylyklpl elgtfhqlfk hlgtediist kqyvevlsri fknsegkqld pnemrtvkrv
     3841 vsglfrslqn dsvkvrsdle nvrdlalylp sqdgrlvkss ilvfddaphy ksriqgnigv
     3901 qmlvdlsqcy lgkdhgfhtk limlfpqklr prllssilee qldeetpkvc qfgalcslqg
     3961 rlqlllsseq fitglirimk hendnaflan eekairlcka lreglkvscf eklqttlrvk
     4021 gfnpiphsrs etfaflkrfg navillyiqh sdskdinfll alamtlksat dnlisdtsyl
     4081 iamlgcndiy rigekldslg vkydssepsk lelpmpgtpi paeihytllm dpmnvfypge
     4141 yvgylvdaeg gdiygsyqpt ytyaiivqev eredadnssf lgkiyqidig yseykivssl
     4201 dlykfsrpee ssqsrdsaps tptspteflt pglrsipplf sgreshktss khqspkklkv
     4261 nslpeilkev tsvveqawkl peserkkiir rlylkwhpdk npenhdiane vfkhlqnein
     4321 rlekqafldq nadrasrrtf stsasrfqsd kysfqrfyts wnqeatshks erqqqnkekc
     4381 ppsagqtysq rffvpptfks vgnpvearrw lrqaranfsa arndlhknan ewvcfkcyls
     4441 tklaliaady avrgksdkdv kptalaqkie eysqqleglt ndvhtleayg vdslktrypd
     4501 llpfpqipnd rftsevamrv mectaciiik lenfmqqkv
//
LOCUS       XP_047286214            4539 aa            linear   PRI 05-AUG-2025
DEFINITION  sacsin isoform X7 [Homo sapiens].
ACCESSION   XP_047286214
VERSION     XP_047286214.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430258.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4539
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..4539
                     /product="sacsin isoform X7"
                     /calculated_mol_wt=516500
     Region          7..78
                     /region_name="Ubl_Sacsin"
                     /note="ubiquitin-like (Ubl) domain found in Sacsin and
                     similar proteins; cd17049"
                     /db_xref="CDD:340569"
     Region          <4282..>4317
                     /region_name="DnaJ"
                     /note="DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock
                     protein 40) proteins are highly conserved and play crucial
                     roles in protein translation, folding, unfolding,
                     translocation, and degradation. They act primarily by
                     stimulating the ATPase activity of Hsp70s; cl02542"
                     /db_xref="CDD:413365"
     Region          4411..4527
                     /region_name="HEPN"
                     /note="Higher Eukarytoes and Prokaryotes
                     Nucleotide-binding domain; smart00748"
                     /db_xref="CDD:214800"
     CDS             1..4539
                     /gene="SACS"
                     /gene_synonym="ARSACS; DNAJC29; PPP1R138; SPAX6"
                     /coded_by="XM_047430258.1:811..14430"
                     /db_xref="GeneID:26278"
                     /db_xref="HGNC:HGNC:10519"
                     /db_xref="MIM:604490"
ORIGIN      
        1 metkenrwvp vtvlpgcvgc rtvaalaswt vrdvkerifa etgfpvseqr lwrggrelsd
       61 wikigdltsk nchlfvnlqs kglkgggrfg qttpplvdfl kdilrrypeg gqilkeliqn
      121 aedagatevk flydetqygt etlwskdmap yqdvpcifsg dqigmldphq tlfgphesgq
      181 cwnlkddske iselsdqfap fvgifgstke tfingnfpgt ffrfplrlqp sqlssnlynk
      241 qkvlelfesf radadtvllf lksvqdvsly vreadgtekl vfrvtssesk alkherpnsi
      301 kilgtaisny ckktpsnnit cvtyhvnivl eeestkdaqk tswlvcnsvg grgissklds
      361 ladelkfvpi igiamplssr ddeakgatsd fsgkafcflp lppgeesstg lpvhisgffg
      421 ltdnrrsikw reldqwrdpa alwneflvmn vvpkayatli ldsikrleme kssdfplsvd
      481 viyklwpeas kvkvhwqpvl eplfsellqn aviysiscdw vrleqvyfse ldenleytkt
      541 vlnylqssgk qiakvpgnvd aavqltaasg ttpvrkvtpa wvrqvlrkca hlgcaeeklh
      601 llefvlsdqa ysellglell plqngnfvpf sssvsdqdvi yitsaeyprs lfpslegrfi
      661 ldnlkphlva alkeaaqtra qqqlwgysgr pctqlqllnp erfarlikev mntfwpgrel
      721 ivqwypfden rnhpsvswlk mvwknlyihf sedltlfdem pliprtilee gqtcvelirl
      781 ripslvildd eseaqlpefl adivqklggf vlkkldasiq hplikkyihs plpsavlqim
      841 ekmplqklcn qitsllpthk dalrkflasl tdssekekri iqelaifkri nhssdqgiss
      901 ytklkgckvl hhtaklpadl rlsisvidss deatirlanm lkieqlktts clklvlkdie
      961 nafysheevt qlmlwvlenl sslknenpnv lewltplkfi qisqeqmvsa gelfdpdiev
     1021 lkdlfcneeg tyfppsvfts pdilhslrqi glkneaslke kdvvqvakki ealqvgacpd
     1081 qdvllkkakt lllvlnknht llqssegkmt lkkikwvpac kerppnypgs lvwkgdlcnl
     1141 cappdmcdvg hailigsslp lvesihvnle kalgiftkps lsavlkhfki vvdwyssktf
     1201 sdedyyqfqh illeiygfmh dhlnegkdsf ralkfpwvwt gkkfcplaqa vikpihdldl
     1261 qpylhnvpkt makfhqlfkv cgsieeltsd hismviqkiy lksdqdlseq eskqnlhlml
     1321 niirwlysnq ipaspntpvp ihhsknpskl imkpiheccy cdikvddlnd lledsvepii
     1381 lvhedipmkt aewlkvpcls trlinpenmg feqsgqrepl tvriknilee ypsvsdifke
     1441 llqnaddana tecsflidmr rnmdirenll dpgmaachgp alwsfnnsqf sdsdfvnitr
     1501 lgeslkrgev dkvgkfglgf nsvyhitdip iimsrefmim fdpninhisk hikdksnpgi
     1561 kinwskqqkr lrkfpnqfkp fidvfgcqlp ltveapysyn gtlfrlsfrt qqeakvsevs
     1621 stcyntadiy slvdefslcg hrliiftqsv ksmylkylki eetnpslaqd tviikkkscs
     1681 skalntpvls vlkeaaklmk tcsssnkklp sdepksscil qitveefhhv frriadlqsp
     1741 lfrgpdddpa alfemaksgq skkpsdelsq ktvecttwll ctcmdtgeal kfslsesgrr
     1801 lglvpcgavg vqlseiqdqk wtvkphigev fcylplrikt glpvhingcf avtsnrkeiw
     1861 ktdtkgrwnt tfmrhvivka ylqvlsvlrd latsgelmdy tyyavwpdpd lvhddfsvic
     1921 qgfyediahg kgkeltkvfs dgstwvsmkn vrflddsilk rrdvgsaafk iflkylkktg
     1981 sknlcavelp ssvklgfeea gckqillent fsekqffsev ffpniqeiea elrdplmifv
     2041 lnekvdefsg vlrvtpcipc sleghplvlp srlihpegrv aklfdikdgr fpygstqdyl
     2101 npiiliklvq lgmakddilw ddmleravsv aeinksdhva aclrssills lideklkird
     2161 prakdfaaky qtirflpflt kpagfsldwk gnsfkpetmf aatdlytaeh qdivcllqpi
     2221 lnenshsfrg cgsvslavke flgllkkptv dlvinqlkev aksvddgitl yqenitnacy
     2281 kylhealmqn eitkmsiidk lkpfsfilve nayvdsekvs fhlnfeaapy lyqlpnkykn
     2341 nfrelfetvg vrqsctvedf alvlesidqe rgtkqiteen fqlcrriise giwslirekk
     2401 qefceknygk illpdtnlml lpakslcynd cpwikvkdtt vkychadipr evavklgavp
     2461 krhkalerya snvcfttlgt efgqkeklts riksilnayp sekemlkell qnaddakate
     2521 icfvfdprqh pvdrifddkw aplqgpalcv ynnqpftedd vrgiqnlgkg tkegnpyktg
     2581 qygigfnsvy hitdcpsfis gndilcifdp haryapgats ispgrmfrdl dadfrtqfsd
     2641 vldlylgthf kldnctmfrf plrnaemakv seissvpasd rmvqnlldkl rsdgaellmf
     2701 lnhmekisic eidkstgaln vlysvkgkit dgdrlkrkqf hasvidsvtk krqlkdipvq
     2761 qitytmdted segnlttwli cnrsgfssme kvsksvisah knqditlfpr ggvaacithn
     2821 ykkphrafcf lplsletglp fhvnghfald sarrnlwrdd ngvgvrsdwn nslmtaliap
     2881 ayvelliqlk kryfpgsdpt lsvlqntpih vvkdtlkkfl sffpvnrldl qpdlyclvka
     2941 lyncihedmk rllpvvrapn idgsdlhsav iitwinmsts nktrpffdnl lqdelqhlkn
     3001 adynittrkt vaenvyrlkh llleigfnlv yncdetanly hclidadipv syvtpadirs
     3061 flmtfsspdt nchigklpcr lqqtnlklfh slkllvdycf kdaeeneiev eglpllitld
     3121 svlqtfdakr pkflttyhel ipsrkdlfmn tlylkysnil lnckvakvfd issfadllss
     3181 vlpreyktks ctkwkdnfas eswlknawhf isesvsvked qeetkptfdi vvdtlkdwal
     3241 lpgtkftvsa nqlvvpegdv llplslmhia vfpnaqsdkv fhalmkagci qlalnkicsk
     3301 dsafvpllsc htaniespts ilkalhymvq tstfraeklv endfeallmy fncnlnhlms
     3361 qddikilksl pcyksisgry vsigkfgtcy vltksipsae vekwtqssss afleekihlk
     3421 elyevigcvp vddlevylkh llpkienlsy daklehliyl knrlssaeel seikeqlfek
     3481 leslliihda nsrlkqakhf ydrtvrvfev mlpeklfipn dffkkleqli kpknhvtfmt
     3541 swveflrnig lkyilsqqql lqfakeisvr antenwsket lqntvdillh hifqermdll
     3601 sgnflkelsl ipflcperap aefirfhpqy qevngtlpli kfngaqvnpk fkqcdvlqll
     3661 wtscpilpek atplsikeqe gsdlgpqeql eqvlnmlnvn ldppldkvin ncrnicnitt
     3721 ldeemvktra kvlrsiyefl saekrefrfq lrgvafvmve dgwkllkpee vvinleyesd
     3781 fkpylyklpl elgtfhqlfk hlgtediist kqyvevlsri fknsegkqld pnemrtvkrv
     3841 vsglfrslqn dsvkvrsdle nvrdlalylp sqdgrlvkss ilvfddaphy ksriqgnigv
     3901 qmlvdlsqcy lgkdhgfhtk limlfpqklr prllssilee qldeetpkvc qfgalcslqg
     3961 rlqlllsseq fitglirimk hendnaflan eekairlcka lreglkvscf eklqttlrvk
     4021 gfnpiphsrs etfaflkrfg navillyiqh sdskdinfll alamtlksat dnlisdtsyl
     4081 iamlgcndiy rigekldslg vkydssepsk lelpmpgtpi paeihytllm dpmnvfypge
     4141 yvgylvdaeg gdiygsyqpt ytyaiivqev eredadnssf lgkiyqidig yseykivssl
     4201 dlykfsrpee ssqsrdsaps tptspteflt pglrsipplf sgreshktss khqspkklkv
     4261 nslpeilkev tsvveqawkl peserkkiir rlylkwhpdk npenhdiane vfkhlqnein
     4321 rlekqafldq nadrasrrtf stsasrfqsd kysfqrfyts wnqeatshks erqqqnkekc
     4381 ppsagqtysq rffvpptfks vgnpvearrw lrqaranfsa arndlhknan ewvcfkcyls
     4441 tklaliaady avrgksdkdv kptalaqkie eysqqleglt ndvhtleayg vdslktrypd
     4501 llpfpqipnd rftsevamrv mectaciiik lenfmqqkv
//
LOCUS       XP_047286215            4538 aa            linear   PRI 05-AUG-2025
DEFINITION  sacsin isoform X8 [Homo sapiens].
ACCESSION   XP_047286215
VERSION     XP_047286215.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430259.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4538
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..4538
                     /product="sacsin isoform X8"
                     /calculated_mol_wt=516325
     Region          15..86
                     /region_name="Ubl_Sacsin"
                     /note="ubiquitin-like (Ubl) domain found in Sacsin and
                     similar proteins; cd17049"
                     /db_xref="CDD:340569"
     Region          <4281..>4316
                     /region_name="DnaJ"
                     /note="DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock
                     protein 40) proteins are highly conserved and play crucial
                     roles in protein translation, folding, unfolding,
                     translocation, and degradation. They act primarily by
                     stimulating the ATPase activity of Hsp70s; cl02542"
                     /db_xref="CDD:413365"
     Region          4410..4526
                     /region_name="HEPN"
                     /note="Higher Eukarytoes and Prokaryotes
                     Nucleotide-binding domain; smart00748"
                     /db_xref="CDD:214800"
     CDS             1..4538
                     /gene="SACS"
                     /gene_synonym="ARSACS; DNAJC29; PPP1R138; SPAX6"
                     /coded_by="XM_047430259.1:38..13654"
                     /db_xref="GeneID:26278"
                     /db_xref="HGNC:HGNC:10519"
                     /db_xref="MIM:604490"
ORIGIN      
        1 mrippsrpar glwtrwvpvt vlpgcvgcrt vaalaswtvr dvkerifaet gfpvseqrlw
       61 rggrelsdwi kigdltsknc hlfvnlqskg lkgggrfgqt tpplvdflkd ilrrypeggq
      121 ilkeliqnae dagatevkfl ydetqygtet lwskdmapyq dvpcifsgdq igmldphqtl
      181 fgphesgqcw nlkddskeis elsdqfapfv gifgstketf ingnfpgtff rfplrlqpsq
      241 lssnlynkqk vlelfesfra dadtvllflk svqdvslyvr eadgteklvf rvtsseskal
      301 kherpnsiki lgtaisnyck ktpsnnitcv tyhvnivlee estkdaqkts wlvcnsvggr
      361 gisskldsla delkfvpiig iamplssrdd eakgatsdfs gkafcflplp pgeesstglp
      421 vhisgffglt dnrrsikwre ldqwrdpaal wneflvmnvv pkayatlild sikrlemeks
      481 sdfplsvdvi yklwpeaskv kvhwqpvlep lfsellqnav iysiscdwvr leqvyfseld
      541 enleytktvl nylqssgkqi akvpgnvdaa vqltaasgtt pvrkvtpawv rqvlrkcahl
      601 gcaeeklhll efvlsdqays ellglellpl qngnfvpfss svsdqdviyi tsaeyprslf
      661 pslegrfild nlkphlvaal keaaqtrgrp ctqlqllnpe rfarlikevm ntfwpgreli
      721 vqwypfdenr nhpsvswlkm vwknlyihfs edltlfdemp liprtileeg qtcvelirlr
      781 ipslvildde seaqlpefla divqklggfv lkkldasiqh plikkyihsp lpsavlqime
      841 kmplqklcnq itsllpthkd alrkflaslt dssekekrii qelaifkrin hssdqgissy
      901 tklkgckvlh htaklpadlr lsisvidssd eatirlanml kieqlkttsc lklvlkdien
      961 afysheevtq lmlwvlenls slknenpnvl ewltplkfiq isqeqmvsag elfdpdievl
     1021 kdlfcneegt yfppsvftsp dilhslrqig lkneaslkek dvvqvakkie alqvgacpdq
     1081 dvllkkaktl llvlnknhtl lqssegkmtl kkikwvpack erppnypgsl vwkgdlcnlc
     1141 appdmcdvgh ailigsslpl vesihvnlek algiftkpsl savlkhfkiv vdwyssktfs
     1201 dedyyqfqhi lleiygfmhd hlnegkdsfr alkfpwvwtg kkfcplaqav ikpihdldlq
     1261 pylhnvpktm akfhqlfkvc gsieeltsdh ismviqkiyl ksdqdlseqe skqnlhlmln
     1321 iirwlysnqi paspntpvpi hhsknpskli mkpiheccyc dikvddlndl ledsvepiil
     1381 vhedipmkta ewlkvpclst rlinpenmgf eqsgqreplt vriknileey psvsdifkel
     1441 lqnaddanat ecsflidmrr nmdirenlld pgmaachgpa lwsfnnsqfs dsdfvnitrl
     1501 geslkrgevd kvgkfglgfn svyhitdipi imsrefmimf dpninhiskh ikdksnpgik
     1561 inwskqqkrl rkfpnqfkpf idvfgcqlpl tveapysyng tlfrlsfrtq qeakvsevss
     1621 tcyntadiys lvdefslcgh rliiftqsvk smylkylkie etnpslaqdt viikkkscss
     1681 kalntpvlsv lkeaaklmkt csssnkklps depksscilq itveefhhvf rriadlqspl
     1741 frgpdddpaa lfemaksgqs kkpsdelsqk tvecttwllc tcmdtgealk fslsesgrrl
     1801 glvpcgavgv qlseiqdqkw tvkphigevf cylplriktg lpvhingcfa vtsnrkeiwk
     1861 tdtkgrwntt fmrhvivkay lqvlsvlrdl atsgelmdyt yyavwpdpdl vhddfsvicq
     1921 gfyediahgk gkeltkvfsd gstwvsmknv rflddsilkr rdvgsaafki flkylkktgs
     1981 knlcavelps svklgfeeag ckqillentf sekqffsevf fpniqeieae lrdplmifvl
     2041 nekvdefsgv lrvtpcipcs leghplvlps rlihpegrva klfdikdgrf pygstqdyln
     2101 piiliklvql gmakddilwd dmleravsva einksdhvaa clrssillsl ideklkirdp
     2161 rakdfaakyq tirflpfltk pagfsldwkg nsfkpetmfa atdlytaehq divcllqpil
     2221 nenshsfrgc gsvslavkef lgllkkptvd lvinqlkeva ksvddgitly qenitnacyk
     2281 ylhealmqne itkmsiidkl kpfsfilven ayvdsekvsf hlnfeaapyl yqlpnkyknn
     2341 frelfetvgv rqsctvedfa lvlesidqer gtkqiteenf qlcrriiseg iwslirekkq
     2401 efceknygki llpdtnlmll pakslcyndc pwikvkdttv kychadipre vavklgavpk
     2461 rhkaleryas nvcfttlgte fgqkekltsr iksilnayps ekemlkellq naddakatei
     2521 cfvfdprqhp vdrifddkwa plqgpalcvy nnqpfteddv rgiqnlgkgt kegnpyktgq
     2581 ygigfnsvyh itdcpsfisg ndilcifdph aryapgatsi spgrmfrdld adfrtqfsdv
     2641 ldlylgthfk ldnctmfrfp lrnaemakvs eissvpasdr mvqnlldklr sdgaellmfl
     2701 nhmekisice idkstgalnv lysvkgkitd gdrlkrkqfh asvidsvtkk rqlkdipvqq
     2761 itytmdteds egnlttwlic nrsgfssmek vsksvisahk nqditlfprg gvaacithny
     2821 kkphrafcfl plsletglpf hvnghfalds arrnlwrddn gvgvrsdwnn slmtaliapa
     2881 yvelliqlkk ryfpgsdptl svlqntpihv vkdtlkkfls ffpvnrldlq pdlyclvkal
     2941 yncihedmkr llpvvrapni dgsdlhsavi itwinmstsn ktrpffdnll qdelqhlkna
     3001 dynittrktv aenvyrlkhl lleigfnlvy ncdetanlyh clidadipvs yvtpadirsf
     3061 lmtfsspdtn chigklpcrl qqtnlklfhs lkllvdycfk daeeneieve glpllitlds
     3121 vlqtfdakrp kflttyheli psrkdlfmnt lylkysnill nckvakvfdi ssfadllssv
     3181 lpreyktksc tkwkdnfase swlknawhfi sesvsvkedq eetkptfdiv vdtlkdwall
     3241 pgtkftvsan qlvvpegdvl lplslmhiav fpnaqsdkvf halmkagciq lalnkicskd
     3301 safvpllsch taniesptsi lkalhymvqt stfraeklve ndfeallmyf ncnlnhlmsq
     3361 ddikilkslp cyksisgryv sigkfgtcyv ltksipsaev ekwtqssssa fleekihlke
     3421 lyevigcvpv ddlevylkhl lpkienlsyd aklehliylk nrlssaeels eikeqlfekl
     3481 eslliihdan srlkqakhfy drtvrvfevm lpeklfipnd ffkkleqlik pknhvtfmts
     3541 wveflrnigl kyilsqqqll qfakeisvra ntenwsketl qntvdillhh ifqermdlls
     3601 gnflkelsli pflcperapa efirfhpqyq evngtlplik fngaqvnpkf kqcdvlqllw
     3661 tscpilpeka tplsikeqeg sdlgpqeqle qvlnmlnvnl dppldkvinn crnicnittl
     3721 deemvktrak vlrsiyefls aekrefrfql rgvafvmved gwkllkpeev vinleyesdf
     3781 kpylyklple lgtfhqlfkh lgtediistk qyvevlsrif knsegkqldp nemrtvkrvv
     3841 sglfrslqnd svkvrsdlen vrdlalylps qdgrlvkssi lvfddaphyk sriqgnigvq
     3901 mlvdlsqcyl gkdhgfhtkl imlfpqklrp rllssileeq ldeetpkvcq fgalcslqgr
     3961 lqlllsseqf itglirimkh endnaflane ekairlckal reglkvscfe klqttlrvkg
     4021 fnpiphsrse tfaflkrfgn avillyiqhs dskdinflla lamtlksatd nlisdtsyli
     4081 amlgcndiyr igekldslgv kydssepskl elpmpgtpip aeihytllmd pmnvfypgey
     4141 vgylvdaegg diygsyqpty tyaiivqeve redadnssfl gkiyqidigy seykivssld
     4201 lykfsrpees sqsrdsapst ptsptefltp glrsipplfs greshktssk hqspkklkvn
     4261 slpeilkevt svveqawklp eserkkiirr lylkwhpdkn penhdianev fkhlqneinr
     4321 lekqafldqn adrasrrtfs tsasrfqsdk ysfqrfytsw nqeatshkse rqqqnkekcp
     4381 psagqtysqr ffvpptfksv gnpvearrwl rqaranfsaa rndlhknane wvcfkcylst
     4441 klaliaadya vrgksdkdvk ptalaqkiee ysqqlegltn dvhtleaygv dslktrypdl
     4501 lpfpqipndr ftsevamrvm ectaciiikl enfmqqkv
//
LOCUS       XP_047286216            4536 aa            linear   PRI 05-AUG-2025
DEFINITION  sacsin isoform X9 [Homo sapiens].
ACCESSION   XP_047286216
VERSION     XP_047286216.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430260.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4536
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..4536
                     /product="sacsin isoform X9"
                     /calculated_mol_wt=516213
     Region          4..75
                     /region_name="Ubl_Sacsin"
                     /note="ubiquitin-like (Ubl) domain found in Sacsin and
                     similar proteins; cd17049"
                     /db_xref="CDD:340569"
     Region          <4279..>4314
                     /region_name="DnaJ"
                     /note="DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock
                     protein 40) proteins are highly conserved and play crucial
                     roles in protein translation, folding, unfolding,
                     translocation, and degradation. They act primarily by
                     stimulating the ATPase activity of Hsp70s; cl02542"
                     /db_xref="CDD:413365"
     Region          4408..4524
                     /region_name="HEPN"
                     /note="Higher Eukarytoes and Prokaryotes
                     Nucleotide-binding domain; smart00748"
                     /db_xref="CDD:214800"
     CDS             1..4536
                     /gene="SACS"
                     /gene_synonym="ARSACS; DNAJC29; PPP1R138; SPAX6"
                     /coded_by="XM_047430260.1:147..13757"
                     /db_xref="GeneID:26278"
                     /db_xref="HGNC:HGNC:10519"
                     /db_xref="MIM:604490"
ORIGIN      
        1 mwerwvpvtv lpgcvgcrtv aalaswtvrd vkerifaetg fpvseqrlwr ggrelsdwik
       61 igdltsknch lfvnlqskgl kgggrfgqtt pplvdflkdi lrrypeggqi lkeliqnaed
      121 agatevkfly detqygtetl wskdmapyqd vpcifsgdqi gmldphqtlf gphesgqcwn
      181 lkddskeise lsdqfapfvg ifgstketfi ngnfpgtffr fplrlqpsql ssnlynkqkv
      241 lelfesfrad adtvllflks vqdvslyvre adgteklvfr vtsseskalk herpnsikil
      301 gtaisnyckk tpsnnitcvt yhvnivleee stkdaqktsw lvcnsvggrg isskldslad
      361 elkfvpiigi amplssrdde akgatsdfsg kafcflplpp geesstglpv hisgffgltd
      421 nrrsikwrel dqwrdpaalw neflvmnvvp kayatlilds ikrlemekss dfplsvdviy
      481 klwpeaskvk vhwqpvlepl fsellqnavi ysiscdwvrl eqvyfselde nleytktvln
      541 ylqssgkqia kvpgnvdaav qltaasgttp vrkvtpawvr qvlrkcahlg caeeklhlle
      601 fvlsdqayse llglellplq ngnfvpfsss vsdqdviyit saeyprslfp slegrfildn
      661 lkphlvaalk eaaqtraqqq lwgysgrpct qlqllnperf arlikevmnt fwpgrelivq
      721 wypfdenrnh psvswlkmvw knlyihfsed ltlfdempli prtileegqt cvelirlrip
      781 slvilddese aqlpefladi vqklggfvlk kldasiqhpl ikkyihsplp savlqimekm
      841 plqklcnqit sllpthkdal rkflasltds sekekriiqe laifkrinhs sdqgissytk
      901 lkgckvlhht aklpadlrls isvidssdea tirlanmlki eqlkttsclk lvlkdienaf
      961 ysheevtqlm lwvlenlssl knenpnvlew ltplkfiqis qeqmvsagel fdpdievlkd
     1021 lfcneegtyf ppsvftspdi lhslrqiglk neaslkekdv vqvakkieal qvgacpdqdv
     1081 llkkaktlll vlnknhtllq ssegkmtlkk ikwvpacker ppnypgslvw kgdlcnlcap
     1141 pdmcdvghai ligsslplve sihvnlekal giftkpslsa vlkhfkivvd wyssktfsde
     1201 dyyqfqhill eiygfmhdhl negkdsfral kfpwvwtgkk fcplaqavik pihdldlqpy
     1261 lhnvpktmak fhqlfkvcgs ieeltsdhis mviqkiylks dqdlseqesk qnlhlmlnii
     1321 rwlysnqipa spntpvpihh sknpsklimk piheccycdi kvddlndlle dsvepiilvh
     1381 edipmktaew lkvpclstrl inpenmgfeq sgqrepltvr iknileeyps vsdifkellq
     1441 naddanatec sflidmrrnm direnlldpg maachgpalw sfnnsqfsds dfvnitrlge
     1501 slkrgevdkv gkfglgfnsv yhitdipiim srefmimfdp ninhiskhik dksnpgikin
     1561 wskqqkrlrk fpnqfkpfid vfgcqlpltv eapysyngtl frlsfrtqqe akvsevsstc
     1621 yntadiyslv defslcghrl iiftqsvksm ylkylkieet npslaqdtvi ikkkscsska
     1681 lntpvlsvlk eaaklmktcs ssnkklpsde pksscilqit veefhhvfrr iadlqsplfr
     1741 gpdddpaalf emaksgqskk psdelsqktv ecttwllctc mdtgealkfs lsesgrrlgl
     1801 vpcgavgvql seiqdqkwtv kphigevfcy lplriktglp vhingcfavt snrkeiwktd
     1861 tkgrwnttfm rhvivkaylq vlsvlrdlat sgelmdytyy avwpdpdlvh ddfsvicqgf
     1921 yediahgkgk eltkvfsdgs twvsmknvrf lddsilkrrd vgsaafkifl kylkktgskn
     1981 lcavelpssv klgfeeagck qillentfse kqffsevffp niqeieaelr dplmifvlne
     2041 kvdefsgvlr vtpcipcsle ghplvlpsrl ihpegrvakl fdikdgrfpy gstqdylnpi
     2101 iliklvqlgm akddilwddm leravsvaei nksdhvaacl rssillslid eklkirdpra
     2161 kdfaakyqti rflpfltkpa gfsldwkgns fkpetmfaat dlytaehqdi vcllqpilne
     2221 nshsfrgcgs vslavkeflg llkkptvdlv inqlkevaks vddgitlyqe nitnacykyl
     2281 healmqneit kmsiidklkp fsfilvenay vdsekvsfhl nfeaapylyq lpnkyknnfr
     2341 elfetvgvrq sctvedfalv lesidqergt kqiteenfql crriisegiw slirekkqef
     2401 ceknygkill pdtnlmllpa kslcyndcpw ikvkdttvky chadipreva vklgavpkrh
     2461 kaleryasnv cfttlgtefg qkekltsrik silnaypsek emlkellqna ddakateicf
     2521 vfdprqhpvd rifddkwapl qgpalcvynn qpfteddvrg iqnlgkgtke gnpyktgqyg
     2581 igfnsvyhit dcpsfisgnd ilcifdphar yapgatsisp grmfrdldad frtqfsdvld
     2641 lylgthfkld nctmfrfplr naemakvsei ssvpasdrmv qnlldklrsd gaellmflnh
     2701 mekisiceid kstgalnvly svkgkitdgd rlkrkqfhas vidsvtkkrq lkdipvqqit
     2761 ytmdtedseg nlttwlicnr sgfssmekvs ksvisahknq ditlfprggv aacithnykk
     2821 phrafcflpl sletglpfhv nghfaldsar rnlwrddngv gvrsdwnnsl mtaliapayv
     2881 elliqlkkry fpgsdptlsv lqntpihvvk dtlkkflsff pvnrldlqpd lyclvkalyn
     2941 cihedmkrll pvvrapnidg sdlhsaviit winmstsnkt rpffdnllqd elqhlknady
     3001 nittrktvae nvyrlkhlll eigfnlvync detanlyhcl idadipvsyv tpadirsflm
     3061 tfsspdtnch igklpcrlqq tnlklfhslk llvdycfkda eeneievegl pllitldsvl
     3121 qtfdakrpkf lttyhelips rkdlfmntly lkysnillnc kvakvfdiss fadllssvlp
     3181 reyktksctk wkdnfasesw lknawhfise svsvkedqee tkptfdivvd tlkdwallpg
     3241 tkftvsanql vvpegdvllp lslmhiavfp naqsdkvfha lmkagciqla lnkicskdsa
     3301 fvpllschta niesptsilk alhymvqtst fraeklvend feallmyfnc nlnhlmsqdd
     3361 ikilkslpcy ksisgryvsi gkfgtcyvlt ksipsaevek wtqssssafl eekihlkely
     3421 evigcvpvdd levylkhllp kienlsydak lehliylknr lssaeelsei keqlfekles
     3481 lliihdansr lkqakhfydr tvrvfevmlp eklfipndff kkleqlikpk nhvtfmtswv
     3541 eflrniglky ilsqqqllqf akeisvrant enwsketlqn tvdillhhif qermdllsgn
     3601 flkelslipf lcperapaef irfhpqyqev ngtlplikfn gaqvnpkfkq cdvlqllwts
     3661 cpilpekatp lsikeqegsd lgpqeqleqv lnmlnvnldp pldkvinncr nicnittlde
     3721 emvktrakvl rsiyeflsae krefrfqlrg vafvmvedgw kllkpeevvi nleyesdfkp
     3781 ylyklplelg tfhqlfkhlg tediistkqy vevlsrifkn segkqldpne mrtvkrvvsg
     3841 lfrslqndsv kvrsdlenvr dlalylpsqd grlvkssilv fddaphyksr iqgnigvqml
     3901 vdlsqcylgk dhgfhtklim lfpqklrprl lssileeqld eetpkvcqfg alcslqgrlq
     3961 lllsseqfit glirimkhen dnaflaneek airlckalre glkvscfekl qttlrvkgfn
     4021 piphsrsetf aflkrfgnav illyiqhsds kdinfllala mtlksatdnl isdtsyliam
     4081 lgcndiyrig ekldslgvky dssepsklel pmpgtpipae ihytllmdpm nvfypgeyvg
     4141 ylvdaeggdi ygsyqptyty aiivqevere dadnssflgk iyqidigyse ykivssldly
     4201 kfsrpeessq srdsapstpt sptefltpgl rsipplfsgr eshktsskhq spkklkvnsl
     4261 peilkevtsv veqawklpes erkkiirrly lkwhpdknpe nhdianevfk hlqneinrle
     4321 kqafldqnad rasrrtfsts asrfqsdkys fqrfytswnq eatshkserq qqnkekcpps
     4381 agqtysqrff vpptfksvgn pvearrwlrq aranfsaarn dlhknanewv cfkcylstkl
     4441 aliaadyavr gksdkdvkpt alaqkieeys qqlegltndv htleaygvds lktrypdllp
     4501 fpqipndrft sevamrvmec taciiiklen fmqqkv
//
LOCUS       XP_047286217            4530 aa            linear   PRI 05-AUG-2025
DEFINITION  sacsin isoform X10 [Homo sapiens].
ACCESSION   XP_047286217
VERSION     XP_047286217.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430261.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4530
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..4530
                     /product="sacsin isoform X10"
                     /calculated_mol_wt=515437
     Region          7..78
                     /region_name="Ubl_Sacsin"
                     /note="ubiquitin-like (Ubl) domain found in Sacsin and
                     similar proteins; cd17049"
                     /db_xref="CDD:340569"
     Region          <4273..>4308
                     /region_name="DnaJ"
                     /note="DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock
                     protein 40) proteins are highly conserved and play crucial
                     roles in protein translation, folding, unfolding,
                     translocation, and degradation. They act primarily by
                     stimulating the ATPase activity of Hsp70s; cl02542"
                     /db_xref="CDD:413365"
     Region          4402..4518
                     /region_name="HEPN"
                     /note="Higher Eukarytoes and Prokaryotes
                     Nucleotide-binding domain; smart00748"
                     /db_xref="CDD:214800"
     CDS             1..4530
                     /gene="SACS"
                     /gene_synonym="ARSACS; DNAJC29; PPP1R138; SPAX6"
                     /coded_by="XM_047430261.1:590..14182"
                     /db_xref="GeneID:26278"
                     /db_xref="HGNC:HGNC:10519"
                     /db_xref="MIM:604490"
ORIGIN      
        1 metkenrwvp vtvlpgcvgc rtvaalaswt vrdvkerifa etgfpvseqr lwrggrelsd
       61 wikigdltsk nchlfvnlqs kglkgggrfg qttpplvdfl kdilrrypeg gqilkeliqn
      121 aedagatevk flydetqygt etlwskdmap yqdvpcifsg dqigmldphq tlfgphesgq
      181 cwnlkddske iselsdqfap fvgifgstke tfingnfpgt ffrfplrlqp sqlssnlynk
      241 qkvlelfesf radadtvllf lksvqdvsly vreadgtekl vfrvtssesk alkherpnsi
      301 kilgtaisny ckktpsnnit cvtyhvnivl eeestkdaqk tswlvcnsvg grgissklds
      361 ladelkfvpi igiamplssr ddeakgatsd fsgkafcflp lppgeesstg lpvhisgffg
      421 ltdnrrsikw reldqwrdpa alwneflvmn vvpkayatli ldsikrleme kssdfplsvd
      481 viyklwpeas kvkvhwqpvl eplfsellqn aviysiscdw vrleqvyfse ldenleytkt
      541 vlnylqssgk qiakvpgnvd aavqltaasg ttpvrkvtpa wvrqvlrkca hlgcaeeklh
      601 llefvlsdqa ysellglell plqngnfvpf sssvsdqdvi yitsaeyprs lfpslegrfi
      661 ldnlkphlva alkeaaqtrg rpctqlqlln perfarlike vmntfwpgre livqwypfde
      721 nrnhpsvswl kmvwknlyih fsedltlfde mpliprtile egqtcvelir lripslvild
      781 deseaqlpef ladivqklgg fvlkkldasi qhplikkyih splpsavlqi mekmplqklc
      841 nqitsllpth kdalrkflas ltdssekekr iiqelaifkr inhssdqgis sytklkgckv
      901 lhhtaklpad lrlsisvids sdeatirlan mlkieqlktt sclklvlkdi enafysheev
      961 tqlmlwvlen lsslknenpn vlewltplkf iqisqeqmvs agelfdpdie vlkdlfcnee
     1021 gtyfppsvft spdilhslrq iglkneaslk ekdvvqvakk iealqvgacp dqdvllkkak
     1081 tlllvlnknh tllqssegkm tlkkikwvpa ckerppnypg slvwkgdlcn lcappdmcdv
     1141 ghailigssl plvesihvnl ekalgiftkp slsavlkhfk ivvdwysskt fsdedyyqfq
     1201 hilleiygfm hdhlnegkds fralkfpwvw tgkkfcplaq avikpihdld lqpylhnvpk
     1261 tmakfhqlfk vcgsieelts dhismviqki ylksdqdlse qeskqnlhlm lniirwlysn
     1321 qipaspntpv pihhsknpsk limkpihecc ycdikvddln dlledsvepi ilvhedipmk
     1381 taewlkvpcl strlinpenm gfeqsgqrep ltvriknile eypsvsdifk ellqnaddan
     1441 atecsflidm rrnmdirenl ldpgmaachg palwsfnnsq fsdsdfvnit rlgeslkrge
     1501 vdkvgkfglg fnsvyhitdi piimsrefmi mfdpninhis khikdksnpg ikinwskqqk
     1561 rlrkfpnqfk pfidvfgcql pltveapysy ngtlfrlsfr tqqeakvsev sstcyntadi
     1621 yslvdefslc ghrliiftqs vksmylkylk ieetnpslaq dtviikkksc sskalntpvl
     1681 svlkeaaklm ktcsssnkkl psdepkssci lqitveefhh vfrriadlqs plfrgpdddp
     1741 aalfemaksg qskkpsdels qktvecttwl lctcmdtgea lkfslsesgr rlglvpcgav
     1801 gvqlseiqdq kwtvkphige vfcylplrik tglpvhingc favtsnrkei wktdtkgrwn
     1861 ttfmrhvivk aylqvlsvlr dlatsgelmd ytyyavwpdp dlvhddfsvi cqgfyediah
     1921 gkgkeltkvf sdgstwvsmk nvrflddsil krrdvgsaaf kiflkylkkt gsknlcavel
     1981 pssvklgfee agckqillen tfsekqffse vffpniqeie aelrdplmif vlnekvdefs
     2041 gvlrvtpcip csleghplvl psrlihpegr vaklfdikdg rfpygstqdy lnpiiliklv
     2101 qlgmakddil wddmleravs vaeinksdhv aaclrssill slideklkir dprakdfaak
     2161 yqtirflpfl tkpagfsldw kgnsfkpetm faatdlytae hqdivcllqp ilnenshsfr
     2221 gcgsvslavk eflgllkkpt vdlvinqlke vaksvddgit lyqenitnac ykylhealmq
     2281 neitkmsiid klkpfsfilv enayvdsekv sfhlnfeaap ylyqlpnkyk nnfrelfetv
     2341 gvrqsctved falvlesidq ergtkqitee nfqlcrriis egiwslirek kqefceknyg
     2401 killpdtnlm llpakslcyn dcpwikvkdt tvkychadip revavklgav pkrhkalery
     2461 asnvcfttlg tefgqkeklt sriksilnay psekemlkel lqnaddakat eicfvfdprq
     2521 hpvdrifddk waplqgpalc vynnqpfted dvrgiqnlgk gtkegnpykt gqygigfnsv
     2581 yhitdcpsfi sgndilcifd pharyapgat sispgrmfrd ldadfrtqfs dvldlylgth
     2641 fkldnctmfr fplrnaemak vseissvpas drmvqnlldk lrsdgaellm flnhmekisi
     2701 ceidkstgal nvlysvkgki tdgdrlkrkq fhasvidsvt kkrqlkdipv qqitytmdte
     2761 dsegnlttwl icnrsgfssm ekvsksvisa hknqditlfp rggvaacith nykkphrafc
     2821 flplsletgl pfhvnghfal dsarrnlwrd dngvgvrsdw nnslmtalia payvelliql
     2881 kkryfpgsdp tlsvlqntpi hvvkdtlkkf lsffpvnrld lqpdlyclvk alyncihedm
     2941 krllpvvrap nidgsdlhsa viitwinmst snktrpffdn llqdelqhlk nadynittrk
     3001 tvaenvyrlk hllleigfnl vyncdetanl yhclidadip vsyvtpadir sflmtfsspd
     3061 tnchigklpc rlqqtnlklf hslkllvdyc fkdaeeneie veglpllitl dsvlqtfdak
     3121 rpkflttyhe lipsrkdlfm ntlylkysni llnckvakvf dissfadlls svlpreyktk
     3181 sctkwkdnfa seswlknawh fisesvsvke dqeetkptfd ivvdtlkdwa llpgtkftvs
     3241 anqlvvpegd vllplslmhi avfpnaqsdk vfhalmkagc iqlalnkics kdsafvplls
     3301 chtaniespt silkalhymv qtstfraekl vendfeallm yfncnlnhlm sqddikilks
     3361 lpcyksisgr yvsigkfgtc yvltksipsa evekwtqsss safleekihl kelyevigcv
     3421 pvddlevylk hllpkienls ydaklehliy lknrlssaee lseikeqlfe kleslliihd
     3481 ansrlkqakh fydrtvrvfe vmlpeklfip ndffkkleql ikpknhvtfm tswveflrni
     3541 glkyilsqqq llqfakeisv rantenwske tlqntvdill hhifqermdl lsgnflkels
     3601 lipflcpera paefirfhpq yqevngtlpl ikfngaqvnp kfkqcdvlql lwtscpilpe
     3661 katplsikeq egsdlgpqeq leqvlnmlnv nldppldkvi nncrnicnit tldeemvktr
     3721 akvlrsiyef lsaekrefrf qlrgvafvmv edgwkllkpe evvinleyes dfkpylyklp
     3781 lelgtfhqlf khlgtediis tkqyvevlsr ifknsegkql dpnemrtvkr vvsglfrslq
     3841 ndsvkvrsdl envrdlalyl psqdgrlvks silvfddaph yksriqgnig vqmlvdlsqc
     3901 ylgkdhgfht klimlfpqkl rprllssile eqldeetpkv cqfgalcslq grlqlllsse
     3961 qfitglirim khendnafla neekairlck alreglkvsc feklqttlrv kgfnpiphsr
     4021 setfaflkrf gnavillyiq hsdskdinfl lalamtlksa tdnlisdtsy liamlgcndi
     4081 yrigekldsl gvkydsseps klelpmpgtp ipaeihytll mdpmnvfypg eyvgylvdae
     4141 ggdiygsyqp tytyaiivqe veredadnss flgkiyqidi gyseykivss ldlykfsrpe
     4201 essqsrdsap stptsptefl tpglrsippl fsgreshkts skhqspkklk vnslpeilke
     4261 vtsvveqawk lpeserkkii rrlylkwhpd knpenhdian evfkhlqnei nrlekqafld
     4321 qnadrasrrt fstsasrfqs dkysfqrfyt swnqeatshk serqqqnkek cppsagqtys
     4381 qrffvpptfk svgnpvearr wlrqaranfs aarndlhkna newvcfkcyl stklaliaad
     4441 yavrgksdkd vkptalaqki eeysqqlegl tndvhtleay gvdslktryp dllpfpqipn
     4501 drftsevamr vmectaciii klenfmqqkv
//
LOCUS       XP_047286218            4530 aa            linear   PRI 05-AUG-2025
DEFINITION  sacsin isoform X10 [Homo sapiens].
ACCESSION   XP_047286218
VERSION     XP_047286218.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430262.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4530
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..4530
                     /product="sacsin isoform X10"
                     /calculated_mol_wt=515437
     Region          7..78
                     /region_name="Ubl_Sacsin"
                     /note="ubiquitin-like (Ubl) domain found in Sacsin and
                     similar proteins; cd17049"
                     /db_xref="CDD:340569"
     Region          <4273..>4308
                     /region_name="DnaJ"
                     /note="DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock
                     protein 40) proteins are highly conserved and play crucial
                     roles in protein translation, folding, unfolding,
                     translocation, and degradation. They act primarily by
                     stimulating the ATPase activity of Hsp70s; cl02542"
                     /db_xref="CDD:413365"
     Region          4402..4518
                     /region_name="HEPN"
                     /note="Higher Eukarytoes and Prokaryotes
                     Nucleotide-binding domain; smart00748"
                     /db_xref="CDD:214800"
     CDS             1..4530
                     /gene="SACS"
                     /gene_synonym="ARSACS; DNAJC29; PPP1R138; SPAX6"
                     /coded_by="XM_047430262.1:811..14403"
                     /db_xref="GeneID:26278"
                     /db_xref="HGNC:HGNC:10519"
                     /db_xref="MIM:604490"
ORIGIN      
        1 metkenrwvp vtvlpgcvgc rtvaalaswt vrdvkerifa etgfpvseqr lwrggrelsd
       61 wikigdltsk nchlfvnlqs kglkgggrfg qttpplvdfl kdilrrypeg gqilkeliqn
      121 aedagatevk flydetqygt etlwskdmap yqdvpcifsg dqigmldphq tlfgphesgq
      181 cwnlkddske iselsdqfap fvgifgstke tfingnfpgt ffrfplrlqp sqlssnlynk
      241 qkvlelfesf radadtvllf lksvqdvsly vreadgtekl vfrvtssesk alkherpnsi
      301 kilgtaisny ckktpsnnit cvtyhvnivl eeestkdaqk tswlvcnsvg grgissklds
      361 ladelkfvpi igiamplssr ddeakgatsd fsgkafcflp lppgeesstg lpvhisgffg
      421 ltdnrrsikw reldqwrdpa alwneflvmn vvpkayatli ldsikrleme kssdfplsvd
      481 viyklwpeas kvkvhwqpvl eplfsellqn aviysiscdw vrleqvyfse ldenleytkt
      541 vlnylqssgk qiakvpgnvd aavqltaasg ttpvrkvtpa wvrqvlrkca hlgcaeeklh
      601 llefvlsdqa ysellglell plqngnfvpf sssvsdqdvi yitsaeyprs lfpslegrfi
      661 ldnlkphlva alkeaaqtrg rpctqlqlln perfarlike vmntfwpgre livqwypfde
      721 nrnhpsvswl kmvwknlyih fsedltlfde mpliprtile egqtcvelir lripslvild
      781 deseaqlpef ladivqklgg fvlkkldasi qhplikkyih splpsavlqi mekmplqklc
      841 nqitsllpth kdalrkflas ltdssekekr iiqelaifkr inhssdqgis sytklkgckv
      901 lhhtaklpad lrlsisvids sdeatirlan mlkieqlktt sclklvlkdi enafysheev
      961 tqlmlwvlen lsslknenpn vlewltplkf iqisqeqmvs agelfdpdie vlkdlfcnee
     1021 gtyfppsvft spdilhslrq iglkneaslk ekdvvqvakk iealqvgacp dqdvllkkak
     1081 tlllvlnknh tllqssegkm tlkkikwvpa ckerppnypg slvwkgdlcn lcappdmcdv
     1141 ghailigssl plvesihvnl ekalgiftkp slsavlkhfk ivvdwysskt fsdedyyqfq
     1201 hilleiygfm hdhlnegkds fralkfpwvw tgkkfcplaq avikpihdld lqpylhnvpk
     1261 tmakfhqlfk vcgsieelts dhismviqki ylksdqdlse qeskqnlhlm lniirwlysn
     1321 qipaspntpv pihhsknpsk limkpihecc ycdikvddln dlledsvepi ilvhedipmk
     1381 taewlkvpcl strlinpenm gfeqsgqrep ltvriknile eypsvsdifk ellqnaddan
     1441 atecsflidm rrnmdirenl ldpgmaachg palwsfnnsq fsdsdfvnit rlgeslkrge
     1501 vdkvgkfglg fnsvyhitdi piimsrefmi mfdpninhis khikdksnpg ikinwskqqk
     1561 rlrkfpnqfk pfidvfgcql pltveapysy ngtlfrlsfr tqqeakvsev sstcyntadi
     1621 yslvdefslc ghrliiftqs vksmylkylk ieetnpslaq dtviikkksc sskalntpvl
     1681 svlkeaaklm ktcsssnkkl psdepkssci lqitveefhh vfrriadlqs plfrgpdddp
     1741 aalfemaksg qskkpsdels qktvecttwl lctcmdtgea lkfslsesgr rlglvpcgav
     1801 gvqlseiqdq kwtvkphige vfcylplrik tglpvhingc favtsnrkei wktdtkgrwn
     1861 ttfmrhvivk aylqvlsvlr dlatsgelmd ytyyavwpdp dlvhddfsvi cqgfyediah
     1921 gkgkeltkvf sdgstwvsmk nvrflddsil krrdvgsaaf kiflkylkkt gsknlcavel
     1981 pssvklgfee agckqillen tfsekqffse vffpniqeie aelrdplmif vlnekvdefs
     2041 gvlrvtpcip csleghplvl psrlihpegr vaklfdikdg rfpygstqdy lnpiiliklv
     2101 qlgmakddil wddmleravs vaeinksdhv aaclrssill slideklkir dprakdfaak
     2161 yqtirflpfl tkpagfsldw kgnsfkpetm faatdlytae hqdivcllqp ilnenshsfr
     2221 gcgsvslavk eflgllkkpt vdlvinqlke vaksvddgit lyqenitnac ykylhealmq
     2281 neitkmsiid klkpfsfilv enayvdsekv sfhlnfeaap ylyqlpnkyk nnfrelfetv
     2341 gvrqsctved falvlesidq ergtkqitee nfqlcrriis egiwslirek kqefceknyg
     2401 killpdtnlm llpakslcyn dcpwikvkdt tvkychadip revavklgav pkrhkalery
     2461 asnvcfttlg tefgqkeklt sriksilnay psekemlkel lqnaddakat eicfvfdprq
     2521 hpvdrifddk waplqgpalc vynnqpfted dvrgiqnlgk gtkegnpykt gqygigfnsv
     2581 yhitdcpsfi sgndilcifd pharyapgat sispgrmfrd ldadfrtqfs dvldlylgth
     2641 fkldnctmfr fplrnaemak vseissvpas drmvqnlldk lrsdgaellm flnhmekisi
     2701 ceidkstgal nvlysvkgki tdgdrlkrkq fhasvidsvt kkrqlkdipv qqitytmdte
     2761 dsegnlttwl icnrsgfssm ekvsksvisa hknqditlfp rggvaacith nykkphrafc
     2821 flplsletgl pfhvnghfal dsarrnlwrd dngvgvrsdw nnslmtalia payvelliql
     2881 kkryfpgsdp tlsvlqntpi hvvkdtlkkf lsffpvnrld lqpdlyclvk alyncihedm
     2941 krllpvvrap nidgsdlhsa viitwinmst snktrpffdn llqdelqhlk nadynittrk
     3001 tvaenvyrlk hllleigfnl vyncdetanl yhclidadip vsyvtpadir sflmtfsspd
     3061 tnchigklpc rlqqtnlklf hslkllvdyc fkdaeeneie veglpllitl dsvlqtfdak
     3121 rpkflttyhe lipsrkdlfm ntlylkysni llnckvakvf dissfadlls svlpreyktk
     3181 sctkwkdnfa seswlknawh fisesvsvke dqeetkptfd ivvdtlkdwa llpgtkftvs
     3241 anqlvvpegd vllplslmhi avfpnaqsdk vfhalmkagc iqlalnkics kdsafvplls
     3301 chtaniespt silkalhymv qtstfraekl vendfeallm yfncnlnhlm sqddikilks
     3361 lpcyksisgr yvsigkfgtc yvltksipsa evekwtqsss safleekihl kelyevigcv
     3421 pvddlevylk hllpkienls ydaklehliy lknrlssaee lseikeqlfe kleslliihd
     3481 ansrlkqakh fydrtvrvfe vmlpeklfip ndffkkleql ikpknhvtfm tswveflrni
     3541 glkyilsqqq llqfakeisv rantenwske tlqntvdill hhifqermdl lsgnflkels
     3601 lipflcpera paefirfhpq yqevngtlpl ikfngaqvnp kfkqcdvlql lwtscpilpe
     3661 katplsikeq egsdlgpqeq leqvlnmlnv nldppldkvi nncrnicnit tldeemvktr
     3721 akvlrsiyef lsaekrefrf qlrgvafvmv edgwkllkpe evvinleyes dfkpylyklp
     3781 lelgtfhqlf khlgtediis tkqyvevlsr ifknsegkql dpnemrtvkr vvsglfrslq
     3841 ndsvkvrsdl envrdlalyl psqdgrlvks silvfddaph yksriqgnig vqmlvdlsqc
     3901 ylgkdhgfht klimlfpqkl rprllssile eqldeetpkv cqfgalcslq grlqlllsse
     3961 qfitglirim khendnafla neekairlck alreglkvsc feklqttlrv kgfnpiphsr
     4021 setfaflkrf gnavillyiq hsdskdinfl lalamtlksa tdnlisdtsy liamlgcndi
     4081 yrigekldsl gvkydsseps klelpmpgtp ipaeihytll mdpmnvfypg eyvgylvdae
     4141 ggdiygsyqp tytyaiivqe veredadnss flgkiyqidi gyseykivss ldlykfsrpe
     4201 essqsrdsap stptsptefl tpglrsippl fsgreshkts skhqspkklk vnslpeilke
     4261 vtsvveqawk lpeserkkii rrlylkwhpd knpenhdian evfkhlqnei nrlekqafld
     4321 qnadrasrrt fstsasrfqs dkysfqrfyt swnqeatshk serqqqnkek cppsagqtys
     4381 qrffvpptfk svgnpvearr wlrqaranfs aarndlhkna newvcfkcyl stklaliaad
     4441 yavrgksdkd vkptalaqki eeysqqlegl tndvhtleay gvdslktryp dllpfpqipn
     4501 drftsevamr vmectaciii klenfmqqkv
//
LOCUS       XP_047286219            4527 aa            linear   PRI 05-AUG-2025
DEFINITION  sacsin isoform X11 [Homo sapiens].
ACCESSION   XP_047286219
VERSION     XP_047286219.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430263.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4527
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..4527
                     /product="sacsin isoform X11"
                     /calculated_mol_wt=515151
     Region          4..75
                     /region_name="Ubl_Sacsin"
                     /note="ubiquitin-like (Ubl) domain found in Sacsin and
                     similar proteins; cd17049"
                     /db_xref="CDD:340569"
     Region          <4270..>4305
                     /region_name="DnaJ"
                     /note="DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock
                     protein 40) proteins are highly conserved and play crucial
                     roles in protein translation, folding, unfolding,
                     translocation, and degradation. They act primarily by
                     stimulating the ATPase activity of Hsp70s; cl02542"
                     /db_xref="CDD:413365"
     Region          4399..4515
                     /region_name="HEPN"
                     /note="Higher Eukarytoes and Prokaryotes
                     Nucleotide-binding domain; smart00748"
                     /db_xref="CDD:214800"
     CDS             1..4527
                     /gene="SACS"
                     /gene_synonym="ARSACS; DNAJC29; PPP1R138; SPAX6"
                     /coded_by="XM_047430263.1:147..13730"
                     /db_xref="GeneID:26278"
                     /db_xref="HGNC:HGNC:10519"
                     /db_xref="MIM:604490"
ORIGIN      
        1 mwerwvpvtv lpgcvgcrtv aalaswtvrd vkerifaetg fpvseqrlwr ggrelsdwik
       61 igdltsknch lfvnlqskgl kgggrfgqtt pplvdflkdi lrrypeggqi lkeliqnaed
      121 agatevkfly detqygtetl wskdmapyqd vpcifsgdqi gmldphqtlf gphesgqcwn
      181 lkddskeise lsdqfapfvg ifgstketfi ngnfpgtffr fplrlqpsql ssnlynkqkv
      241 lelfesfrad adtvllflks vqdvslyvre adgteklvfr vtsseskalk herpnsikil
      301 gtaisnyckk tpsnnitcvt yhvnivleee stkdaqktsw lvcnsvggrg isskldslad
      361 elkfvpiigi amplssrdde akgatsdfsg kafcflplpp geesstglpv hisgffgltd
      421 nrrsikwrel dqwrdpaalw neflvmnvvp kayatlilds ikrlemekss dfplsvdviy
      481 klwpeaskvk vhwqpvlepl fsellqnavi ysiscdwvrl eqvyfselde nleytktvln
      541 ylqssgkqia kvpgnvdaav qltaasgttp vrkvtpawvr qvlrkcahlg caeeklhlle
      601 fvlsdqayse llglellplq ngnfvpfsss vsdqdviyit saeyprslfp slegrfildn
      661 lkphlvaalk eaaqtrgrpc tqlqllnper farlikevmn tfwpgreliv qwypfdenrn
      721 hpsvswlkmv wknlyihfse dltlfdempl iprtileegq tcvelirlri pslvilddes
      781 eaqlpeflad ivqklggfvl kkldasiqhp likkyihspl psavlqimek mplqklcnqi
      841 tsllpthkda lrkflasltd ssekekriiq elaifkrinh ssdqgissyt klkgckvlhh
      901 taklpadlrl sisvidssde atirlanmlk ieqlkttscl klvlkdiena fysheevtql
      961 mlwvlenlss lknenpnvle wltplkfiqi sqeqmvsage lfdpdievlk dlfcneegty
     1021 fppsvftspd ilhslrqigl kneaslkekd vvqvakkiea lqvgacpdqd vllkkaktll
     1081 lvlnknhtll qssegkmtlk kikwvpacke rppnypgslv wkgdlcnlca ppdmcdvgha
     1141 iligsslplv esihvnleka lgiftkpsls avlkhfkivv dwyssktfsd edyyqfqhil
     1201 leiygfmhdh lnegkdsfra lkfpwvwtgk kfcplaqavi kpihdldlqp ylhnvpktma
     1261 kfhqlfkvcg sieeltsdhi smviqkiylk sdqdlseqes kqnlhlmlni irwlysnqip
     1321 aspntpvpih hsknpsklim kpiheccycd ikvddlndll edsvepiilv hedipmktae
     1381 wlkvpclstr linpenmgfe qsgqrepltv riknileeyp svsdifkell qnaddanate
     1441 csflidmrrn mdirenlldp gmaachgpal wsfnnsqfsd sdfvnitrlg eslkrgevdk
     1501 vgkfglgfns vyhitdipii msrefmimfd pninhiskhi kdksnpgiki nwskqqkrlr
     1561 kfpnqfkpfi dvfgcqlplt veapysyngt lfrlsfrtqq eakvsevsst cyntadiysl
     1621 vdefslcghr liiftqsvks mylkylkiee tnpslaqdtv iikkkscssk alntpvlsvl
     1681 keaaklmktc sssnkklpsd epksscilqi tveefhhvfr riadlqsplf rgpdddpaal
     1741 femaksgqsk kpsdelsqkt vecttwllct cmdtgealkf slsesgrrlg lvpcgavgvq
     1801 lseiqdqkwt vkphigevfc ylplriktgl pvhingcfav tsnrkeiwkt dtkgrwnttf
     1861 mrhvivkayl qvlsvlrdla tsgelmdyty yavwpdpdlv hddfsvicqg fyediahgkg
     1921 keltkvfsdg stwvsmknvr flddsilkrr dvgsaafkif lkylkktgsk nlcavelpss
     1981 vklgfeeagc kqillentfs ekqffsevff pniqeieael rdplmifvln ekvdefsgvl
     2041 rvtpcipcsl eghplvlpsr lihpegrvak lfdikdgrfp ygstqdylnp iiliklvqlg
     2101 makddilwdd mleravsvae inksdhvaac lrssillsli deklkirdpr akdfaakyqt
     2161 irflpfltkp agfsldwkgn sfkpetmfaa tdlytaehqd ivcllqpiln enshsfrgcg
     2221 svslavkefl gllkkptvdl vinqlkevak svddgitlyq enitnacyky lhealmqnei
     2281 tkmsiidklk pfsfilvena yvdsekvsfh lnfeaapyly qlpnkyknnf relfetvgvr
     2341 qsctvedfal vlesidqerg tkqiteenfq lcrriisegi wslirekkqe fceknygkil
     2401 lpdtnlmllp akslcyndcp wikvkdttvk ychadiprev avklgavpkr hkaleryasn
     2461 vcfttlgtef gqkekltsri ksilnaypse kemlkellqn addakateic fvfdprqhpv
     2521 drifddkwap lqgpalcvyn nqpfteddvr giqnlgkgtk egnpyktgqy gigfnsvyhi
     2581 tdcpsfisgn dilcifdpha ryapgatsis pgrmfrdlda dfrtqfsdvl dlylgthfkl
     2641 dnctmfrfpl rnaemakvse issvpasdrm vqnlldklrs dgaellmfln hmekisicei
     2701 dkstgalnvl ysvkgkitdg drlkrkqfha svidsvtkkr qlkdipvqqi tytmdtedse
     2761 gnlttwlicn rsgfssmekv sksvisahkn qditlfprgg vaacithnyk kphrafcflp
     2821 lsletglpfh vnghfaldsa rrnlwrddng vgvrsdwnns lmtaliapay velliqlkkr
     2881 yfpgsdptls vlqntpihvv kdtlkkflsf fpvnrldlqp dlyclvkaly ncihedmkrl
     2941 lpvvrapnid gsdlhsavii twinmstsnk trpffdnllq delqhlknad ynittrktva
     3001 envyrlkhll leigfnlvyn cdetanlyhc lidadipvsy vtpadirsfl mtfsspdtnc
     3061 higklpcrlq qtnlklfhsl kllvdycfkd aeeneieveg lpllitldsv lqtfdakrpk
     3121 flttyhelip srkdlfmntl ylkysnilln ckvakvfdis sfadllssvl preyktksct
     3181 kwkdnfases wlknawhfis esvsvkedqe etkptfdivv dtlkdwallp gtkftvsanq
     3241 lvvpegdvll plslmhiavf pnaqsdkvfh almkagciql alnkicskds afvpllscht
     3301 aniesptsil kalhymvqts tfraeklven dfeallmyfn cnlnhlmsqd dikilkslpc
     3361 yksisgryvs igkfgtcyvl tksipsaeve kwtqssssaf leekihlkel yevigcvpvd
     3421 dlevylkhll pkienlsyda klehliylkn rlssaeelse ikeqlfekle slliihdans
     3481 rlkqakhfyd rtvrvfevml peklfipndf fkkleqlikp knhvtfmtsw veflrniglk
     3541 yilsqqqllq fakeisvran tenwsketlq ntvdillhhi fqermdllsg nflkelslip
     3601 flcperapae firfhpqyqe vngtlplikf ngaqvnpkfk qcdvlqllwt scpilpekat
     3661 plsikeqegs dlgpqeqleq vlnmlnvnld ppldkvinnc rnicnittld eemvktrakv
     3721 lrsiyeflsa ekrefrfqlr gvafvmvedg wkllkpeevv inleyesdfk pylyklplel
     3781 gtfhqlfkhl gtediistkq yvevlsrifk nsegkqldpn emrtvkrvvs glfrslqnds
     3841 vkvrsdlenv rdlalylpsq dgrlvkssil vfddaphyks riqgnigvqm lvdlsqcylg
     3901 kdhgfhtkli mlfpqklrpr llssileeql deetpkvcqf galcslqgrl qlllsseqfi
     3961 tglirimkhe ndnaflanee kairlckalr eglkvscfek lqttlrvkgf npiphsrset
     4021 faflkrfgna villyiqhsd skdinfllal amtlksatdn lisdtsylia mlgcndiyri
     4081 gekldslgvk ydssepskle lpmpgtpipa eihytllmdp mnvfypgeyv gylvdaeggd
     4141 iygsyqptyt yaiivqever edadnssflg kiyqidigys eykivssldl ykfsrpeess
     4201 qsrdsapstp tsptefltpg lrsipplfsg reshktsskh qspkklkvns lpeilkevts
     4261 vveqawklpe serkkiirrl ylkwhpdknp enhdianevf khlqneinrl ekqafldqna
     4321 drasrrtfst sasrfqsdky sfqrfytswn qeatshkser qqqnkekcpp sagqtysqrf
     4381 fvpptfksvg npvearrwlr qaranfsaar ndlhknanew vcfkcylstk laliaadyav
     4441 rgksdkdvkp talaqkieey sqqlegltnd vhtleaygvd slktrypdll pfpqipndrf
     4501 tsevamrvme ctaciiikle nfmqqkv
//
LOCUS       XP_011533342             887 aa            linear   PRI 05-AUG-2025
DEFINITION  integrator complex subunit 6 isoform X1 [Homo sapiens].
ACCESSION   XP_011533342
VERSION     XP_011533342.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535040.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..887
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..887
                     /product="integrator complex subunit 6 isoform X1"
                     /calculated_mol_wt=100259
     Region          4..103
                     /region_name="VWA_2"
                     /note="von Willebrand factor type A domain; pfam13519"
                     /db_xref="CDD:463909"
     Region          807..868
                     /region_name="INT_SG_DDX_CT_C"
                     /note="INTS6/SAGE1/DDX26B/CT45 C-terminus; pfam15300"
                     /db_xref="CDD:464626"
     CDS             1..887
                     /gene="INTS6"
                     /gene_synonym="DBI-1; DDX26; DDX26A; DICE1; HDB; INT6;
                     Notchl2"
                     /coded_by="XM_011535040.4:512..3175"
                     /db_xref="GeneID:26512"
                     /db_xref="HGNC:HGNC:14879"
                     /db_xref="MIM:604331"
ORIGIN      
        1 mpillflidt sasmnqrshl gttyldtakg avetfmklra rdpasrgdry mlvtfeeppy
       61 aikagwkenh atfmnelknl qaeglttlgq slrtafdlln lnrlvtgidn ygqgrnpffl
      121 epaiiititd gskltttsgv qdelhlplns plpgseltke pfrwdqrlfa lvlrlpgtms
      181 veseqltgvp lddsaitpmc evtggrsysv csprmlnqcl eslvqkvqsg vvinfekagp
      241 dpspvedgqp disrpfgsqp whschkliyv rpnpktgvpi ghwpvpesfw pdqnsptlpp
      301 rtshpvvkfs ctdcepmvid klpfdkyele pspltqfile rkspqtcwqv yvsnsakyse
      361 lghpfgylka stalncvnlf vmpynypvll pllddlfkvh kakptlkwrq sfesylktmp
      421 pyylgplkka vrmmgapnli adsmeyglsy svisylkkls qqakiesdrv igsvgkkvvq
      481 etgikvrsrs hglsmayrkd fqqllqgise dvphrlldln mkeytgfqva llnkdlkpqt
      541 frnaydiprr nlldhltrmr snllkstrrf lkgqdedqvh svpiaqmgny qeylkqvpsp
      601 lreldpdqpr rlhtfgnpfk ldkkgmmide adefvagpqn khkrpgepnm qgipkrrrcm
      661 spllrgrqqn pvvnnhiggk gppapttqaq pdlikplplh kisettndsi ihdvvenhva
      721 dqlssditpn amdtefsass pasllerptn hmealghdhl gtndltvggf lenheeprdk
      781 eqcaeenipa sslnkgkklm hcrsheevnt elkaqimkei rkpgrkyeri ftllkhvqgs
      841 lqtrliflqn vikeasrfkk rmlieqlenf ldeihrranq inhinsn
//
LOCUS       XP_047286220             673 aa            linear   PRI 05-AUG-2025
DEFINITION  integrator complex subunit 6 isoform X2 [Homo sapiens].
ACCESSION   XP_047286220
VERSION     XP_047286220.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430264.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..673
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..673
                     /product="integrator complex subunit 6 isoform X2"
                     /calculated_mol_wt=76596
     Region          593..654
                     /region_name="INT_SG_DDX_CT_C"
                     /note="INTS6/SAGE1/DDX26B/CT45 C-terminus; pfam15300"
                     /db_xref="CDD:464626"
     CDS             1..673
                     /gene="INTS6"
                     /gene_synonym="DBI-1; DDX26; DDX26A; DICE1; HDB; INT6;
                     Notchl2"
                     /coded_by="XM_047430264.1:53..2074"
                     /db_xref="GeneID:26512"
                     /db_xref="HGNC:HGNC:14879"
                     /db_xref="MIM:604331"
ORIGIN      
        1 mlnqcleslv qkvqsgvvin fekagpdpsp vedgqpdisr pfgsqpwhsc hkliyvrpnp
       61 ktgvpighwp vpesfwpdqn sptlpprtsh pvvkfsctdc epmvidklpf dkyelepspl
      121 tqfilerksp qtcwqvyvsn sakyselghp fgylkastal ncvnlfvmpy nypvllplld
      181 dlfkvhkakp tlkwrqsfes ylktmppyyl gplkkavrmm gapnliadsm eyglsysvis
      241 ylkklsqqak iesdrvigsv gkkvvqetgi kvrsrshgls mayrkdfqql lqgisedvph
      301 rlldlnmkey tgfqvallnk dlkpqtfrna ydiprrnlld hltrmrsnll kstrrflkgq
      361 dedqvhsvpi aqmgnyqeyl kqvpsplrel dpdqprrlht fgnpfkldkk gmmideadef
      421 vagpqnkhkr pgepnmqgip krrrcmspll rgrqqnpvvn nhiggkgppa pttqaqpdli
      481 kplplhkise ttndsiihdv venhvadqls sditpnamdt efsasspasl lerptnhmea
      541 lghdhlgtnd ltvggflenh eeprdkeqca eenipassln kgkklmhcrs heevntelka
      601 qimkeirkpg rkyeriftll khvqgslqtr liflqnvike asrfkkrmli eqlenfldei
      661 hrranqinhi nsn
//
LOCUS       XP_047286221             455 aa            linear   PRI 05-AUG-2025
DEFINITION  integrator complex subunit 6 isoform X3 [Homo sapiens].
ACCESSION   XP_047286221
VERSION     XP_047286221.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430265.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..455
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..455
                     /product="integrator complex subunit 6 isoform X3"
                     /calculated_mol_wt=51771
     Region          375..436
                     /region_name="INT_SG_DDX_CT_C"
                     /note="INTS6/SAGE1/DDX26B/CT45 C-terminus; pfam15300"
                     /db_xref="CDD:464626"
     CDS             1..455
                     /gene="INTS6"
                     /gene_synonym="DBI-1; DDX26; DDX26A; DICE1; HDB; INT6;
                     Notchl2"
                     /coded_by="XM_047430265.1:102..1469"
                     /db_xref="GeneID:26512"
                     /db_xref="HGNC:HGNC:14879"
                     /db_xref="MIM:604331"
ORIGIN      
        1 mmgapnliad smeyglsysv isylkklsqq akiesdrvig svgkkvvqet gikvrsrshg
       61 lsmayrkdfq qllqgisedv phrlldlnmk eytgfqvall nkdlkpqtfr naydiprrnl
      121 ldhltrmrsn llkstrrflk gqdedqvhsv piaqmgnyqe ylkqvpsplr eldpdqprrl
      181 htfgnpfkld kkgmmidead efvagpqnkh krpgepnmqg ipkrrrcmsp llrgrqqnpv
      241 vnnhiggkgp papttqaqpd likplplhki settndsiih dvvenhvadq lssditpnam
      301 dtefsasspa sllerptnhm ealghdhlgt ndltvggfle nheeprdkeq caeenipass
      361 lnkgkklmhc rsheevntel kaqimkeirk pgrkyerift llkhvqgslq trliflqnvi
      421 keasrfkkrm lieqlenfld eihrranqin hinsn
//
LOCUS       XP_047286222            1088 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase LATS2 isoform X1 [Homo sapiens].
ACCESSION   XP_047286222
VERSION     XP_047286222.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430266.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1088
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1088
                     /product="serine/threonine-protein kinase LATS2 isoform
                     X1"
                     /calculated_mol_wt=120005
     Region          101..141
                     /region_name="UBA_LATS2"
                     /note="UBA domain found in vertebrate
                     serine/threonine-protein kinase LATS2; cd14398"
                     /db_xref="CDD:270581"
     Region          <158..460
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          585..667
                     /region_name="MobB_LATS2"
                     /note="Mob-binding domain found in large tumor suppressor
                     homolog 2 (LATS2); cd21777"
                     /db_xref="CDD:439272"
     Site            order(602..603,605..607,609,614,617,620,624,649,653..654,
                     656..658,660)
                     /site_type="other"
                     /note="putative Mob binding site [polypeptide binding]"
                     /db_xref="CDD:439272"
     Region          666..1046
                     /region_name="STKc_LATS2"
                     /note="Catalytic domain of the Protein Serine/Threonine
                     Kinase, Large Tumor Suppressor 2; cd05626"
                     /db_xref="CDD:173715"
     Site            order(674..678,682,695,697,729,745..746,748,752,754,791,
                     793,795..796,798,808..809,812,873..878,905,911,914)
                     /site_type="active"
                     /db_xref="CDD:173715"
     Site            order(674..678,682,695,697,729,746..748,752,791,793,
                     795..796,798,808..809)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:173715"
     Site            order(678,752,754,791,793,795,812,873..878,905,911,914)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:173715"
     Site            order(808..820,868..878)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:173715"
     Site            1037..1042
                     /site_type="other"
                     /note="hydrophobic motif (HM)"
                     /db_xref="CDD:173715"
     CDS             1..1088
                     /gene="LATS2"
                     /gene_synonym="KPM"
                     /coded_by="XM_047430266.1:569..3835"
                     /db_xref="GeneID:26524"
                     /db_xref="HGNC:HGNC:6515"
                     /db_xref="MIM:604861"
ORIGIN      
        1 mrpktfpatt ysgnsrqrlq eireglkqps kssvqglpag pnsdtsldak vlgskdatrq
       61 qqqmratpkf gpyqkalrei rysllpfane sgtsaaaevn rqmlqelvna gcdqemagra
      121 lkqtgsrsie aaleyiskmg yldprneqiv rvikqtspgk glmptpvtrr psfegtgdsf
      181 asyhqlsgtp yegpsfgadg ptaleemprp yvdylfpgvg phgpghqhqh ppkgygasve
      241 aagahfplqg ahygrphllv pgeplgygvq rspsfqsktp petggyaslp tkgqggppga
      301 glafpppaag lyvphphhkq agpaahqlhv lgsrsqvfas dsppqslltp srnslnvdly
      361 elgstsvqqw paatlarrds lqkpgleapp rahvafrpdc pvpsrtnsfn shqprpgppg
      421 kaepslpapn tvtavtaahi lhpvksvrvl rpepqtavgp shpawvpapa papapapapa
      481 aegldakeeh alalggagaf pldveyggpd rrcppppypk hlllrskseq ydldslcagm
      541 eqslragpne peggdksrks akgdkggkdk kqiqtspvpv rknsrdeekr esriksyspy
      601 afkffmeqhv enviktyqqk vnrrlqleqe makaglceae qeqmrkilyq kesnynrlkr
      661 akmdksmfvk iktlgigafg evclackvdt halyamktlr kkdvlnrnqv ahvkaerdil
      721 aeadnewvvk lyysfqdkds lyfvmdyipg gdmmsllirm evfpehlarf yiaeltlaie
      781 svhkmgfihr dikpdnilid ldghikltdf glctgfrwth nskyyqkgsh vrqdsmepsd
      841 lwddvsncrc gdrlktleqr arkqhqrcla hslvgtpnyi apevllrkgy tqlcdwwsvg
      901 vilfemlvgq ppflaptpte tqlkvinwen tlhipaqvkl speardlitk lccsadhrlg
      961 rngaddlkah pffsaidfss dirkqpapyv ptishpmdts nfdpvdeesp wndasegstk
     1021 awdtltspnn khpehafyef tfrrffddng ypfrcpkpsg aeasqaessd lessdlvdqt
     1081 egcqpvyv
//
LOCUS       XP_005266399            1088 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase LATS2 isoform X1 [Homo sapiens].
ACCESSION   XP_005266399
VERSION     XP_005266399.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266342.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1088
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1088
                     /product="serine/threonine-protein kinase LATS2 isoform
                     X1"
                     /calculated_mol_wt=120005
     Region          101..141
                     /region_name="UBA_LATS2"
                     /note="UBA domain found in vertebrate
                     serine/threonine-protein kinase LATS2; cd14398"
                     /db_xref="CDD:270581"
     Region          <158..460
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          585..667
                     /region_name="MobB_LATS2"
                     /note="Mob-binding domain found in large tumor suppressor
                     homolog 2 (LATS2); cd21777"
                     /db_xref="CDD:439272"
     Site            order(602..603,605..607,609,614,617,620,624,649,653..654,
                     656..658,660)
                     /site_type="other"
                     /note="putative Mob binding site [polypeptide binding]"
                     /db_xref="CDD:439272"
     Region          666..1046
                     /region_name="STKc_LATS2"
                     /note="Catalytic domain of the Protein Serine/Threonine
                     Kinase, Large Tumor Suppressor 2; cd05626"
                     /db_xref="CDD:173715"
     Site            order(674..678,682,695,697,729,745..746,748,752,754,791,
                     793,795..796,798,808..809,812,873..878,905,911,914)
                     /site_type="active"
                     /db_xref="CDD:173715"
     Site            order(674..678,682,695,697,729,746..748,752,791,793,
                     795..796,798,808..809)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:173715"
     Site            order(678,752,754,791,793,795,812,873..878,905,911,914)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:173715"
     Site            order(808..820,868..878)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:173715"
     Site            1037..1042
                     /site_type="other"
                     /note="hydrophobic motif (HM)"
                     /db_xref="CDD:173715"
     CDS             1..1088
                     /gene="LATS2"
                     /gene_synonym="KPM"
                     /coded_by="XM_005266342.1:481..3747"
                     /db_xref="GeneID:26524"
                     /db_xref="HGNC:HGNC:6515"
                     /db_xref="MIM:604861"
ORIGIN      
        1 mrpktfpatt ysgnsrqrlq eireglkqps kssvqglpag pnsdtsldak vlgskdatrq
       61 qqqmratpkf gpyqkalrei rysllpfane sgtsaaaevn rqmlqelvna gcdqemagra
      121 lkqtgsrsie aaleyiskmg yldprneqiv rvikqtspgk glmptpvtrr psfegtgdsf
      181 asyhqlsgtp yegpsfgadg ptaleemprp yvdylfpgvg phgpghqhqh ppkgygasve
      241 aagahfplqg ahygrphllv pgeplgygvq rspsfqsktp petggyaslp tkgqggppga
      301 glafpppaag lyvphphhkq agpaahqlhv lgsrsqvfas dsppqslltp srnslnvdly
      361 elgstsvqqw paatlarrds lqkpgleapp rahvafrpdc pvpsrtnsfn shqprpgppg
      421 kaepslpapn tvtavtaahi lhpvksvrvl rpepqtavgp shpawvpapa papapapapa
      481 aegldakeeh alalggagaf pldveyggpd rrcppppypk hlllrskseq ydldslcagm
      541 eqslragpne peggdksrks akgdkggkdk kqiqtspvpv rknsrdeekr esriksyspy
      601 afkffmeqhv enviktyqqk vnrrlqleqe makaglceae qeqmrkilyq kesnynrlkr
      661 akmdksmfvk iktlgigafg evclackvdt halyamktlr kkdvlnrnqv ahvkaerdil
      721 aeadnewvvk lyysfqdkds lyfvmdyipg gdmmsllirm evfpehlarf yiaeltlaie
      781 svhkmgfihr dikpdnilid ldghikltdf glctgfrwth nskyyqkgsh vrqdsmepsd
      841 lwddvsncrc gdrlktleqr arkqhqrcla hslvgtpnyi apevllrkgy tqlcdwwsvg
      901 vilfemlvgq ppflaptpte tqlkvinwen tlhipaqvkl speardlitk lccsadhrlg
      961 rngaddlkah pffsaidfss dirkqpapyv ptishpmdts nfdpvdeesp wndasegstk
     1021 awdtltspnn khpehafyef tfrrffddng ypfrcpkpsg aeasqaessd lessdlvdqt
     1081 egcqpvyv
//
LOCUS       XP_011533344            1001 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase LATS2 isoform X2 [Homo sapiens].
ACCESSION   XP_011533344
VERSION     XP_011533344.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535042.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1001
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1001
                     /product="serine/threonine-protein kinase LATS2 isoform
                     X2"
                     /calculated_mol_wt=110705
     Region          <24..54
                     /region_name="UBA_like_SF"
                     /note="UBA domain-like superfamily; cl21463"
                     /db_xref="CDD:473871"
     Region          <71..373
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          498..580
                     /region_name="MobB_LATS2"
                     /note="Mob-binding domain found in large tumor suppressor
                     homolog 2 (LATS2); cd21777"
                     /db_xref="CDD:439272"
     Site            order(515..516,518..520,522,527,530,533,537,562,566..567,
                     569..571,573)
                     /site_type="other"
                     /note="putative Mob binding site [polypeptide binding]"
                     /db_xref="CDD:439272"
     Region          579..959
                     /region_name="STKc_LATS2"
                     /note="Catalytic domain of the Protein Serine/Threonine
                     Kinase, Large Tumor Suppressor 2; cd05626"
                     /db_xref="CDD:173715"
     Site            order(587..591,595,608,610,642,658..659,661,665,667,704,
                     706,708..709,711,721..722,725,786..791,818,824,827)
                     /site_type="active"
                     /db_xref="CDD:173715"
     Site            order(587..591,595,608,610,642,659..661,665,704,706,
                     708..709,711,721..722)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:173715"
     Site            order(591,665,667,704,706,708,725,786..791,818,824,827)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:173715"
     Site            order(721..733,781..791)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:173715"
     Site            950..955
                     /site_type="other"
                     /note="hydrophobic motif (HM)"
                     /db_xref="CDD:173715"
     CDS             1..1001
                     /gene="LATS2"
                     /gene_synonym="KPM"
                     /coded_by="XM_011535042.3:84..3089"
                     /db_xref="GeneID:26524"
                     /db_xref="HGNC:HGNC:6515"
                     /db_xref="MIM:604861"
ORIGIN      
        1 mqrygcrers lersprlerh cppgalqema gralkqtgsr sieaaleyis kmgyldprne
       61 qivrvikqts pgkglmptpv trrpsfegtg dsfasyhqls gtpyegpsfg adgptaleem
      121 prpyvdylfp gvgphgpghq hqhppkgyga sveaagahfp lqgahygrph llvpgeplgy
      181 gvqrspsfqs ktppetggya slptkgqggp pgaglafppp aaglyvphph hkqagpaahq
      241 lhvlgsrsqv fasdsppqsl ltpsrnslnv dlyelgstsv qqwpaatlar rdslqkpgle
      301 apprahvafr pdcpvpsrtn sfnshqprpg ppgkaepslp apntvtavta ahilhpvksv
      361 rvlrpepqta vgpshpawvp apapapapap apaaegldak eehalalgga gafpldveyg
      421 gpdrrcpppp ypkhlllrsk seqydldslc agmeqslrag pnepeggdks rksakgdkgg
      481 kdkkqiqtsp vpvrknsrde ekresriksy spyafkffme qhvenvikty qqkvnrrlql
      541 eqemakaglc eaeqeqmrki lyqkesnynr lkrakmdksm fvkiktlgig afgevclack
      601 vdthalyamk tlrkkdvlnr nqvahvkaer dilaeadnew vvklyysfqd kdslyfvmdy
      661 ipggdmmsll irmevfpehl arfyiaeltl aiesvhkmgf ihrdikpdni lidldghikl
      721 tdfglctgfr wthnskyyqk gshvrqdsme psdlwddvsn crcgdrlktl eqrarkqhqr
      781 clahslvgtp nyiapevllr kgytqlcdww svgvilfeml vgqppflapt ptetqlkvin
      841 wentlhipaq vklspeardl itklccsadh rlgrngaddl kahpffsaid fssdirkqpa
      901 pyvptishpm dtsnfdpvde espwndaseg stkawdtlts pnnkhpehaf yeftfrrffd
      961 dngypfrcpk psgaeasqae ssdlessdlv dqtegcqpvy v
//
LOCUS       XP_016876030             981 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase LATS2 isoform X3 [Homo sapiens].
ACCESSION   XP_016876030
VERSION     XP_016876030.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020541.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..981
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..981
                     /product="serine/threonine-protein kinase LATS2 isoform
                     X3"
                     /calculated_mol_wt=108380
     Region          <7..34
                     /region_name="UBA_like_SF"
                     /note="UBA domain-like superfamily; cl21463"
                     /db_xref="CDD:473871"
     Region          <51..353
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          478..560
                     /region_name="MobB_LATS2"
                     /note="Mob-binding domain found in large tumor suppressor
                     homolog 2 (LATS2); cd21777"
                     /db_xref="CDD:439272"
     Site            order(495..496,498..500,502,507,510,513,517,542,546..547,
                     549..551,553)
                     /site_type="other"
                     /note="putative Mob binding site [polypeptide binding]"
                     /db_xref="CDD:439272"
     Region          559..939
                     /region_name="STKc_LATS2"
                     /note="Catalytic domain of the Protein Serine/Threonine
                     Kinase, Large Tumor Suppressor 2; cd05626"
                     /db_xref="CDD:173715"
     Site            order(567..571,575,588,590,622,638..639,641,645,647,684,
                     686,688..689,691,701..702,705,766..771,798,804,807)
                     /site_type="active"
                     /db_xref="CDD:173715"
     Site            order(567..571,575,588,590,622,639..641,645,684,686,
                     688..689,691,701..702)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:173715"
     Site            order(571,645,647,684,686,688,705,766..771,798,804,807)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:173715"
     Site            order(701..713,761..771)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:173715"
     Site            930..935
                     /site_type="other"
                     /note="hydrophobic motif (HM)"
                     /db_xref="CDD:173715"
     CDS             1..981
                     /gene="LATS2"
                     /gene_synonym="KPM"
                     /coded_by="XM_017020541.2:182..3127"
                     /db_xref="GeneID:26524"
                     /db_xref="HGNC:HGNC:6515"
                     /db_xref="MIM:604861"
ORIGIN      
        1 mrkralkema gralkqtgsr sieaaleyis kmgyldprne qivrvikqts pgkglmptpv
       61 trrpsfegtg dsfasyhqls gtpyegpsfg adgptaleem prpyvdylfp gvgphgpghq
      121 hqhppkgyga sveaagahfp lqgahygrph llvpgeplgy gvqrspsfqs ktppetggya
      181 slptkgqggp pgaglafppp aaglyvphph hkqagpaahq lhvlgsrsqv fasdsppqsl
      241 ltpsrnslnv dlyelgstsv qqwpaatlar rdslqkpgle apprahvafr pdcpvpsrtn
      301 sfnshqprpg ppgkaepslp apntvtavta ahilhpvksv rvlrpepqta vgpshpawvp
      361 apapapapap apaaegldak eehalalgga gafpldveyg gpdrrcpppp ypkhlllrsk
      421 seqydldslc agmeqslrag pnepeggdks rksakgdkgg kdkkqiqtsp vpvrknsrde
      481 ekresriksy spyafkffme qhvenvikty qqkvnrrlql eqemakaglc eaeqeqmrki
      541 lyqkesnynr lkrakmdksm fvkiktlgig afgevclack vdthalyamk tlrkkdvlnr
      601 nqvahvkaer dilaeadnew vvklyysfqd kdslyfvmdy ipggdmmsll irmevfpehl
      661 arfyiaeltl aiesvhkmgf ihrdikpdni lidldghikl tdfglctgfr wthnskyyqk
      721 gshvrqdsme psdlwddvsn crcgdrlktl eqrarkqhqr clahslvgtp nyiapevllr
      781 kgytqlcdww svgvilfeml vgqppflapt ptetqlkvin wentlhipaq vklspeardl
      841 itklccsadh rlgrngaddl kahpffsaid fssdirkqpa pyvptishpm dtsnfdpvde
      901 espwndaseg stkawdtlts pnnkhpehaf yeftfrrffd dngypfrcpk psgaeasqae
      961 ssdlessdlv dqtegcqpvy v
//
LOCUS       XP_016876031             906 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase LATS2 isoform X4 [Homo sapiens].
ACCESSION   XP_016876031
VERSION     XP_016876031.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020542.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..906
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..906
                     /product="serine/threonine-protein kinase LATS2 isoform
                     X4"
                     /calculated_mol_wt=99393
     Region          101..141
                     /region_name="UBA_LATS2"
                     /note="UBA domain found in vertebrate
                     serine/threonine-protein kinase LATS2; cd14398"
                     /db_xref="CDD:270581"
     Region          <158..460
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          585..667
                     /region_name="MobB_LATS2"
                     /note="Mob-binding domain found in large tumor suppressor
                     homolog 2 (LATS2); cd21777"
                     /db_xref="CDD:439272"
     Site            order(602..603,605..607,609,614,617,620,624,649,653..654,
                     656..658,660)
                     /site_type="other"
                     /note="putative Mob binding site [polypeptide binding]"
                     /db_xref="CDD:439272"
     Region          666..>889
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Site            order(674..677,680,682,695,697,729,745..748,791,795..796,
                     798,808..809)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270870"
     CDS             1..906
                     /gene="LATS2"
                     /gene_synonym="KPM"
                     /coded_by="XM_017020542.2:446..3166"
                     /db_xref="GeneID:26524"
                     /db_xref="HGNC:HGNC:6515"
                     /db_xref="MIM:604861"
ORIGIN      
        1 mrpktfpatt ysgnsrqrlq eireglkqps kssvqglpag pnsdtsldak vlgskdatrq
       61 qqqmratpkf gpyqkalrei rysllpfane sgtsaaaevn rqmlqelvna gcdqemagra
      121 lkqtgsrsie aaleyiskmg yldprneqiv rvikqtspgk glmptpvtrr psfegtgdsf
      181 asyhqlsgtp yegpsfgadg ptaleemprp yvdylfpgvg phgpghqhqh ppkgygasve
      241 aagahfplqg ahygrphllv pgeplgygvq rspsfqsktp petggyaslp tkgqggppga
      301 glafpppaag lyvphphhkq agpaahqlhv lgsrsqvfas dsppqslltp srnslnvdly
      361 elgstsvqqw paatlarrds lqkpgleapp rahvafrpdc pvpsrtnsfn shqprpgppg
      421 kaepslpapn tvtavtaahi lhpvksvrvl rpepqtavgp shpawvpapa papapapapa
      481 aegldakeeh alalggagaf pldveyggpd rrcppppypk hlllrskseq ydldslcagm
      541 eqslragpne peggdksrks akgdkggkdk kqiqtspvpv rknsrdeekr esriksyspy
      601 afkffmeqhv enviktyqqk vnrrlqleqe makaglceae qeqmrkilyq kesnynrlkr
      661 akmdksmfvk iktlgigafg evclackvdt halyamktlr kkdvlnrnqv ahvkaerdil
      721 aeadnewvvk lyysfqdkds lyfvmdyipg gdmmsllirm evfpehlarf yiaeltlaie
      781 svhkmgfihr dikpdnilid ldghikltdf glctgfrwth nskyyqkgsh vrqdsmepsd
      841 lwddvsncrc gdrlktleqr arkqhqrcla hslvgtpnyi apevllrkgd qlgehaphss
      901 pgeaep
//
LOCUS       XP_047286223             906 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase LATS2 isoform X4 [Homo sapiens].
ACCESSION   XP_047286223
VERSION     XP_047286223.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430267.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..906
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..906
                     /product="serine/threonine-protein kinase LATS2 isoform
                     X4"
                     /calculated_mol_wt=99393
     Region          101..141
                     /region_name="UBA_LATS2"
                     /note="UBA domain found in vertebrate
                     serine/threonine-protein kinase LATS2; cd14398"
                     /db_xref="CDD:270581"
     Region          <158..460
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          585..667
                     /region_name="MobB_LATS2"
                     /note="Mob-binding domain found in large tumor suppressor
                     homolog 2 (LATS2); cd21777"
                     /db_xref="CDD:439272"
     Site            order(602..603,605..607,609,614,617,620,624,649,653..654,
                     656..658,660)
                     /site_type="other"
                     /note="putative Mob binding site [polypeptide binding]"
                     /db_xref="CDD:439272"
     Region          666..>889
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Site            order(674..677,680,682,695,697,729,745..748,791,795..796,
                     798,808..809)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270870"
     CDS             1..906
                     /gene="LATS2"
                     /gene_synonym="KPM"
                     /coded_by="XM_047430267.1:1565..4285"
                     /db_xref="GeneID:26524"
                     /db_xref="HGNC:HGNC:6515"
                     /db_xref="MIM:604861"
ORIGIN      
        1 mrpktfpatt ysgnsrqrlq eireglkqps kssvqglpag pnsdtsldak vlgskdatrq
       61 qqqmratpkf gpyqkalrei rysllpfane sgtsaaaevn rqmlqelvna gcdqemagra
      121 lkqtgsrsie aaleyiskmg yldprneqiv rvikqtspgk glmptpvtrr psfegtgdsf
      181 asyhqlsgtp yegpsfgadg ptaleemprp yvdylfpgvg phgpghqhqh ppkgygasve
      241 aagahfplqg ahygrphllv pgeplgygvq rspsfqsktp petggyaslp tkgqggppga
      301 glafpppaag lyvphphhkq agpaahqlhv lgsrsqvfas dsppqslltp srnslnvdly
      361 elgstsvqqw paatlarrds lqkpgleapp rahvafrpdc pvpsrtnsfn shqprpgppg
      421 kaepslpapn tvtavtaahi lhpvksvrvl rpepqtavgp shpawvpapa papapapapa
      481 aegldakeeh alalggagaf pldveyggpd rrcppppypk hlllrskseq ydldslcagm
      541 eqslragpne peggdksrks akgdkggkdk kqiqtspvpv rknsrdeekr esriksyspy
      601 afkffmeqhv enviktyqqk vnrrlqleqe makaglceae qeqmrkilyq kesnynrlkr
      661 akmdksmfvk iktlgigafg evclackvdt halyamktlr kkdvlnrnqv ahvkaerdil
      721 aeadnewvvk lyysfqdkds lyfvmdyipg gdmmsllirm evfpehlarf yiaeltlaie
      781 svhkmgfihr dikpdnilid ldghikltdf glctgfrwth nskyyqkgsh vrqdsmepsd
      841 lwddvsncrc gdrlktleqr arkqhqrcla hslvgtpnyi apevllrkgd qlgehaphss
      901 pgeaep
//
LOCUS       XP_005266401             635 aa            linear   PRI 05-AUG-2025
DEFINITION  cytoskeleton-associated protein 2 isoform X1 [Homo sapiens].
ACCESSION   XP_005266401
VERSION     XP_005266401.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266344.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..635
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..635
                     /product="cytoskeleton-associated protein 2 isoform X1"
                     /calculated_mol_wt=71151
     Region          277..625
                     /region_name="CKAP2_C"
                     /note="Cytoskeleton-associated protein 2 C-terminus;
                     pfam15297"
                     /db_xref="CDD:464623"
     CDS             1..635
                     /gene="CKAP2"
                     /gene_synonym="LB1; se20-10; TMAP"
                     /coded_by="XM_005266344.5:267..2174"
                     /db_xref="GeneID:26586"
                     /db_xref="HGNC:HGNC:1990"
                     /db_xref="MIM:611569"
ORIGIN      
        1 mlsssrdqrv vtsedqvqeg tkvlklktkm adkenmkrpa esknntvvgk hciplkpsne
       61 ltnstvvidt hkpkdsnqtp hlllteddpq sqhmtlsqaf hlknnskkkq mttekqkqda
      121 nmpkkpvlgs yrgqivqski nsfrkplqvk dessaatkkl satipkatkp qpvntssvtv
      181 ksnrssnmta ttkfvsttsq ntqlvrppir shhsntrdtv kqgisrtsan vtirkgphek
      241 ellqsktals svktsssqgi irnktlsrsi aseviarpas lsndklmeks epvdqrrhta
      301 gkaivdsrsa qpketseerk arlsewkagk grvlkrppns vvtqhepagq nekpvgsfwt
      361 tmaeedeqrl ftekvnntfs eclnlinegc pkedilvtln dliknipdak klvkywicla
      421 liepitspie niiaiyekai lagaqpieem rhtivdiltm ksqekanlge nmekscaske
      481 evkevsiedt gvdvdpekle mesklhrnll fqdcekeqdn ktkdpthdvk tpntetrtsc
      541 likynvsttp ylqsvkkkvq fdgtnsafke lkfltpvrrs rrlqektskl pdmlkdhypc
      601 vssleqltel gretdafvcr pnaalcrvyy eadtt
//
LOCUS       XP_047286224             600 aa            linear   PRI 05-AUG-2025
DEFINITION  cytoskeleton-associated protein 2 isoform X2 [Homo sapiens].
ACCESSION   XP_047286224
VERSION     XP_047286224.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430268.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..600
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..600
                     /product="cytoskeleton-associated protein 2 isoform X2"
                     /calculated_mol_wt=67189
     Region          242..590
                     /region_name="CKAP2_C"
                     /note="Cytoskeleton-associated protein 2 C-terminus;
                     pfam15297"
                     /db_xref="CDD:464623"
     CDS             1..600
                     /gene="CKAP2"
                     /gene_synonym="LB1; se20-10; TMAP"
                     /coded_by="XM_047430268.1:293..2095"
                     /db_xref="GeneID:26586"
                     /db_xref="HGNC:HGNC:1990"
                     /db_xref="MIM:611569"
ORIGIN      
        1 mkrpaesknn tvvgkhcipl kpsneltnst vvidthkpkd snqtphlllt eddpqsqhmt
       61 lsqafhlknn skkkqmttek qkqdanmpkk pvlgsyrgqi vqskinsfrk plqvkdessa
      121 atkklsatip katkpqpvnt ssvtvksnrs snmtattkfv sttsqntqlv rppirshhsn
      181 trdtvkqgis rtsanvtirk gphekellqs ktalssvkts ssqgiirnkt lsrsiasevi
      241 arpaslsndk lmeksepvdq rrhtagkaiv dsrsaqpket seerkarlse wkagkgrvlk
      301 rppnsvvtqh epagqnekpv gsfwttmaee deqrlftekv nntfseclnl inegcpkedi
      361 lvtlndlikn ipdakklvky wiclaliepi tspieniiai yekailagaq pieemrhtiv
      421 diltmksqek anlgenmeks caskeevkev siedtgvdvd peklemeskl hrnllfqdce
      481 keqdnktkdp thdvktpnte trtsclikyn vsttpylqsv kkkvqfdgtn safkelkflt
      541 pvrrsrrlqe ktsklpdmlk dhypcvssle qltelgretd afvcrpnaal crvyyeadtt
//
LOCUS       XP_006719866            2962 aa            linear   PRI 05-AUG-2025
DEFINITION  neurobeachin isoform X1 [Homo sapiens].
ACCESSION   XP_006719866
VERSION     XP_006719866.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006719803.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2962
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..2962
                     /product="neurobeachin isoform X1"
                     /calculated_mol_wt=329650
     Region          255..402
                     /region_name="Laminin_G_3"
                     /note="Concanavalin A-like lectin/glucanases superfamily;
                     pfam13385"
                     /db_xref="CDD:463865"
     Region          467..947
                     /region_name="DUF4704"
                     /note="Neurobeachin/BDCP, DUF4704 alpha solenoid region;
                     pfam15787"
                     /db_xref="CDD:464870"
     Region          1966..2132
                     /region_name="DUF1088"
                     /note="Neurobeachin-like, DUF1088; pfam06469"
                     /db_xref="CDD:461925"
     Region          2158..2255
                     /region_name="PH_BEACH"
                     /note="PH domain associated with Beige/BEACH; pfam14844"
                     /db_xref="CDD:434260"
     Region          2287..2584
                     /region_name="Beach"
                     /note="Beige/BEACH domain; pfam02138"
                     /db_xref="CDD:460459"
     Region          2679..2951
                     /region_name="NBCH_WD40"
                     /note="Neurobeachin beta propeller domain; pfam20426"
                     /db_xref="CDD:466575"
     Region          2740..2794
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2799..2834
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2839..2868
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2877..2915
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2923..2949
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..2962
                     /gene="NBEA"
                     /gene_synonym="BCL8B; LYST2; NEDEGE"
                     /coded_by="XM_006719803.4:552..9440"
                     /db_xref="GeneID:26960"
                     /db_xref="HGNC:HGNC:7648"
                     /db_xref="MIM:604889"
ORIGIN      
        1 masekpgpgp glepqpvgli avgaaggggg gsggggtggs gmgelrgasg sgsvmlpagm
       61 inpsvpirni rmkfavligl iqvgevsnrd ivetvlnllv ggefdlemnf iiqdaesitc
      121 mtellehcdv tcqaeiwsmf tailrksvrn lqtstevgli eqvllkmsav ddmiadllvd
      181 mlgvlasysi tvkelkllfs mlrgesgiwp rhavkllsvl nqmpqrhgpd tffnfpgcsa
      241 aaialppiak wpyqngftln twfrmdplnn invdkdkpyl ycfrtskgvg ysahfvgncl
      301 ivtslkskgk gfqhcvkydf qprkwymisi vhiynrwrns eircyvngql vsygdmawhv
      361 ntndsydkcf lgssetadan rvfcgqlgav yvfsealnpa qifaihqlgp gykstfkfks
      421 esdihlaehh kqvlydgkla ssiaftynak atdaqlcles spkenasifv hsphalmlqd
      481 vkaivthsih saihsiggiq vlfplfaqld nrqlndsqve ttvcatllaf lvellkssva
      541 mqeqmlggkg flvigyllek ssrvhitrav leqflsfaky ldglshgapl lkqlcdhilf
      601 npaiwihtpa kvqlslytyl saefigtati yttirrvgtv lqlmhtlkyy ywvinpadss
      661 gitpkgldgp rpsqkeiisl rafmllflkq lilkdrgvke delqsilnyl ltmhedenih
      721 dvlqllvalm sehpasmipa fdqrngirvi ykllaskses iwvqalkvlg yflkhlghkr
      781 kveimhthsl ftllgerlml htntvtvtty ntlyeilteq vctqvvhkph pepdstvkiq
      841 npmilkvvat llknstpsae lmevrrlfls dmiklfsnsr enrrcllqcs vwqdwmfslg
      901 yinpknseeq kitemvynif rillyhaiky ewggwrvwvd tlsiahskvt yeahkeylak
      961 myeeyqrqee enikkgkkgn vstisglssq ttgakggmei reiedlsqsq spesetdypv
     1021 stdtrdllms tkvsddilgn sdrpgsgvhv evhdllvdik aekveatevk lddmdlspet
     1081 lvggengalv eveslldnvy saaveklqnn vhgsvgiikk neekdngpli tladekedlp
     1141 nsstsflfdk ipkqeekllp elssnhiipn iqdtqvhlgv sddlgllahm tgsvdltcts
     1201 siieekefki httsdgmssi serdlasstk gleyaemtat tletessssk ivpnidagsi
     1261 isdtersddg kesgkeirki qtttttqavq grsitqqdrd lrvdlgfrgm pmteeqrrqf
     1321 spgprttmfr ipefkwspmh qrlltdllfa letdvhvwrs hstksvmdfv nsneniifvh
     1381 ntihlisqmv dniiiacggi lpllsaatsp tgskteleni evtqgmsaet avtflsrlma
     1441 mvdvlvfass lnfseieaek nmssgglmrq clrlvccvav rnclecrqrq rdrgnksshg
     1501 sskpqevpqs vtataasktp lenvpgnlsp ikdpdrllqd vdinrlravv frdvddskqa
     1561 qflalavvyf isvlmvskyr dilepqrett rtgsqpgrni rqeinsptst vvvipsiphp
     1621 slnhgflakl ipeqsfghsf yketpaafpd tikeketptp gediqvessi phtdsgigee
     1681 qvasilngae letstgpdam sellstlsse vkksqeslte npsetlkpat sissisqtkg
     1741 invkeilksl vaapveiaec gpepipypdp alkretqail pmqfhsfdrs vvvpvkkppp
     1801 gslavttvga ttagsglptg stsnifaatg atpksmintt gavdsgssss sssssfvnga
     1861 tsknlpavqt vapmpedsae nmsitakler alekvapllr eifvdfapfl srtllgshgq
     1921 ellieglvcm ksstsvvelv mllcsqewqn siqknaglaf ielinegrll chamkdhivr
     1981 vaneaefiln rqraedvhkh aefesqcaqy aadrreeekm cdhlisaakh rdhvtanqlk
     2041 qkilniltnk hgawgavshs qlhdfwrldy weddlrrrrr fvrnafgsth aeallkaaie
     2101 ygteedvvks kktfrsqaiv nqnaetelml egdddavsll qekeidnlag pvvlstpaql
     2161 iapvvvakgt lsittteiyf evdeddsafk kidtkvlayt eglhgkwmfs eiravfsrry
     2221 llqntalevf manrtsvmfn fpdqatvkkv vyslprvgvg tsyglpqarr islatprqly
     2281 kssnmtqrwq rreisnfeyl mflntiagrt yndlnqypvf pwvltnyese eldltlpgnf
     2341 rdlskpigal npkravfyae ryetweddqs ppyhynthys tatstlswlv riepfttffl
     2401 nandgkfdhp drtfssvars wrtsqrdtsd vkelipefyy lpemfvnsng ynlgvredev
     2461 vvndvdlppw akkpedfvri nrmalesefv scqlhqwidl ifgykqrgpe avralnvfhy
     2521 ltyegsvnld sitdpvlrei peayfirdph tflltkdfik ameaqiqnfg qtpsqlliep
     2581 hpprssamhl splmfkdqmq qdvimvlkfp snspvthvaa ntlphltipa vvtvtcsrlf
     2641 avnrwhntvg lrgapgysld qahhlpiemd pliannsgvn krqitdlvdq siqinahcfv
     2701 vtadnryili cgfwdksfrv ystetgkltq ivfghwdvvt clarsesyig gdcyivsgsr
     2761 datlllwyws grhhiigdnp nssdypapra vltghdhevv cvsvcaelgl visgakegpc
     2821 lvhtitgdll ralegpencl fprlisvsse ghciiyyerg rfsnfsingk llaqmeinds
     2881 traillssdg qnlvtggdng vvevwqacdf kqlyiypgcd agiramdlsh dqrtlitgma
     2941 sgsivafnid fnrwhyehqn ry
//
LOCUS       XP_016876033            2961 aa            linear   PRI 05-AUG-2025
DEFINITION  neurobeachin isoform X2 [Homo sapiens].
ACCESSION   XP_016876033
VERSION     XP_016876033.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020544.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2961
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..2961
                     /product="neurobeachin isoform X2"
                     /calculated_mol_wt=329621
     Region          255..402
                     /region_name="Laminin_G_3"
                     /note="Concanavalin A-like lectin/glucanases superfamily;
                     pfam13385"
                     /db_xref="CDD:463865"
     Region          467..947
                     /region_name="DUF4704"
                     /note="Neurobeachin/BDCP, DUF4704 alpha solenoid region;
                     pfam15787"
                     /db_xref="CDD:464870"
     Region          1960..2126
                     /region_name="DUF1088"
                     /note="Neurobeachin-like, DUF1088; pfam06469"
                     /db_xref="CDD:461925"
     Region          2152..2249
                     /region_name="PH_BEACH"
                     /note="PH domain associated with Beige/BEACH; pfam14844"
                     /db_xref="CDD:434260"
     Region          2281..2578
                     /region_name="Beach"
                     /note="Beige/BEACH domain; pfam02138"
                     /db_xref="CDD:460459"
     Region          2678..2950
                     /region_name="NBCH_WD40"
                     /note="Neurobeachin beta propeller domain; pfam20426"
                     /db_xref="CDD:466575"
     Region          2739..2793
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2798..2833
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2838..2867
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2876..2914
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2922..2948
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..2961
                     /gene="NBEA"
                     /gene_synonym="BCL8B; LYST2; NEDEGE"
                     /coded_by="XM_017020544.2:552..9437"
                     /db_xref="GeneID:26960"
                     /db_xref="HGNC:HGNC:7648"
                     /db_xref="MIM:604889"
ORIGIN      
        1 masekpgpgp glepqpvgli avgaaggggg gsggggtggs gmgelrgasg sgsvmlpagm
       61 inpsvpirni rmkfavligl iqvgevsnrd ivetvlnllv ggefdlemnf iiqdaesitc
      121 mtellehcdv tcqaeiwsmf tailrksvrn lqtstevgli eqvllkmsav ddmiadllvd
      181 mlgvlasysi tvkelkllfs mlrgesgiwp rhavkllsvl nqmpqrhgpd tffnfpgcsa
      241 aaialppiak wpyqngftln twfrmdplnn invdkdkpyl ycfrtskgvg ysahfvgncl
      301 ivtslkskgk gfqhcvkydf qprkwymisi vhiynrwrns eircyvngql vsygdmawhv
      361 ntndsydkcf lgssetadan rvfcgqlgav yvfsealnpa qifaihqlgp gykstfkfks
      421 esdihlaehh kqvlydgkla ssiaftynak atdaqlcles spkenasifv hsphalmlqd
      481 vkaivthsih saihsiggiq vlfplfaqld nrqlndsqve ttvcatllaf lvellkssva
      541 mqeqmlggkg flvigyllek ssrvhitrav leqflsfaky ldglshgapl lkqlcdhilf
      601 npaiwihtpa kvqlslytyl saefigtati yttirrvgtv lqlmhtlkyy ywvinpadss
      661 gitpkgldgp rpsqkeiisl rafmllflkq lilkdrgvke delqsilnyl ltmhedenih
      721 dvlqllvalm sehpasmipa fdqrngirvi ykllaskses iwvqalkvlg yflkhlghkr
      781 kveimhthsl ftllgerlml htntvtvtty ntlyeilteq vctqvvhkph pepdstvkiq
      841 npmilkvvat llknstpsae lmevrrlfls dmiklfsnsr enrrcllqcs vwqdwmfslg
      901 yinpknseeq kitemvynif rillyhaiky ewggwrvwvd tlsiahskvt yeahkeylak
      961 myeeyqrqee enikkgkkgn vstisglssq ttgakggmei reiedlsqsq spesetdypv
     1021 stdtrdllms tkvsddilgn sdrpgsgvhv evhdllvdik aekveatevk lddmdlspet
     1081 lvggengalv eveslldnvy saaveklqnn vhgsvgiikk neekdngpli tladekedlp
     1141 nsstsflfdk ipkqeekllp elssnhiipn iqdtqvhlgv sddlgllahm tgsvdltcts
     1201 siieekefki httsdgmssi serdlasstk gleyaemtat tletessssk ivpnidagsi
     1261 isdtersddg kesgkeirki qtttttqavq grsitqqdrd lrvdlgfrgm pmteeqrrqf
     1321 spgprttmfr ipefkwspmh qrlltdllfa letdvhvwrs hstksvmdfv nsneniifvh
     1381 ntihlisqmv dniiiacggi lpllsaatsp tgskteleni evtqgmsaet avtflsrlma
     1441 mvdvlvfass lnfseieaek nmssgglmrq clrlvccvav rnclecrqrq rdrgnksshg
     1501 sskpqevpqs vtataasktp lenvpgnlsp ikdpdrllqd vdinrlravv frdvddskqa
     1561 qflalavvyf isvlmvskyr dilepqrett rtgsqpgrni rqeinsptst vvvipsiphp
     1621 slnhgflakl ipeqsfghsf yketpaafpd tikeketptp gediqvessi phtdsgigee
     1681 qvasilngae letstgpdam sellstlsse vkksqeslte npsetlkpat sissisqtkg
     1741 invkeilksl vaapveiaec gpepipypdp alkretqail pmqfhsfdrs vvvpvkkppp
     1801 gslavttvga ttagsglptg stsnifaatg atpksavdsg sssssssssf vngatsknlp
     1861 avqtvapmpe dsaenmsita kleralekva pllreifvdf apflsrtllg shgqellieg
     1921 lvcmksstsv velvmllcsq ewqnsiqkna glafieline grllchamkd hivrvaneae
     1981 filnrqraed vhkhaefesq caqyaadrre eekmcdhlis aakhrdhvta nqlkqkilni
     2041 ltnkhgawga vshsqlhdfw rldyweddlr rrrrfvrnaf gsthaeallk aaieygteed
     2101 vvkskktfrs qaivnqnaet elmlegddda vsllqekeid nlagpvvlst paqliapvvv
     2161 akgtlsittt eiyfevdedd safkkidtkv layteglhgk wmfseiravf srryllqnta
     2221 levfmanrts vmfnfpdqat vkkvvyslpr vgvgtsyglp qarrislatp rqlykssnmt
     2281 qrwqrreisn feylmflnti agrtyndlnq ypvfpwvltn yeseeldltl pgnfrdlskp
     2341 igalnpkrav fyaeryetwe ddqsppyhyn thystatstl swlvriepft tfflnandgk
     2401 fdhpdrtfss varswrtsqr dtsdvkelip efyylpemfv nsngynlgvr edevvvndvd
     2461 lppwakkped fvrinrmale sefvscqlhq widlifgykq rgpeavraln vfhyltyegs
     2521 vnldsitdpv lreipeayfi rdphtflltk dfikameaqi qnfgqtpsql liephpprss
     2581 amhlcflpqs plmfkdqmqq dvimvlkfps nspvthvaan tlphltipav vtvtcsrlfa
     2641 vnrwhntvgl rgapgysldq ahhlpiemdp liannsgvnk rqitdlvdqs iqinahcfvv
     2701 tadnryilic gfwdksfrvy stetgkltqi vfghwdvvtc larsesyigg dcyivsgsrd
     2761 atlllwywsg rhhiigdnpn ssdypaprav ltghdhevvc vsvcaelglv isgakegpcl
     2821 vhtitgdllr alegpenclf prlisvsseg hciiyyergr fsnfsingkl laqmeindst
     2881 raillssdgq nlvtggdngv vevwqacdfk qlyiypgcda giramdlshd qrtlitgmas
     2941 gsivafnidf nrwhyehqnr y
//
LOCUS       XP_047286225            2958 aa            linear   PRI 05-AUG-2025
DEFINITION  neurobeachin isoform X3 [Homo sapiens].
ACCESSION   XP_047286225
VERSION     XP_047286225.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430269.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2958
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..2958
                     /product="neurobeachin isoform X3"
                     /calculated_mol_wt=329349
     Region          255..402
                     /region_name="Laminin_G_3"
                     /note="Concanavalin A-like lectin/glucanases superfamily;
                     pfam13385"
                     /db_xref="CDD:463865"
     Region          467..947
                     /region_name="DUF4704"
                     /note="Neurobeachin/BDCP, DUF4704 alpha solenoid region;
                     pfam15787"
                     /db_xref="CDD:464870"
     Region          1957..2123
                     /region_name="DUF1088"
                     /note="Neurobeachin-like, DUF1088; pfam06469"
                     /db_xref="CDD:461925"
     Region          2149..2246
                     /region_name="PH_BEACH"
                     /note="PH domain associated with Beige/BEACH; pfam14844"
                     /db_xref="CDD:434260"
     Region          2278..2575
                     /region_name="Beach"
                     /note="Beige/BEACH domain; pfam02138"
                     /db_xref="CDD:460459"
     Region          2675..2947
                     /region_name="NBCH_WD40"
                     /note="Neurobeachin beta propeller domain; pfam20426"
                     /db_xref="CDD:466575"
     Region          2736..2790
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2795..2830
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2835..2864
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2873..2911
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2919..2945
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..2958
                     /gene="NBEA"
                     /gene_synonym="BCL8B; LYST2; NEDEGE"
                     /coded_by="XM_047430269.1:552..9428"
                     /db_xref="GeneID:26960"
                     /db_xref="HGNC:HGNC:7648"
                     /db_xref="MIM:604889"
ORIGIN      
        1 masekpgpgp glepqpvgli avgaaggggg gsggggtggs gmgelrgasg sgsvmlpagm
       61 inpsvpirni rmkfavligl iqvgevsnrd ivetvlnllv ggefdlemnf iiqdaesitc
      121 mtellehcdv tcqaeiwsmf tailrksvrn lqtstevgli eqvllkmsav ddmiadllvd
      181 mlgvlasysi tvkelkllfs mlrgesgiwp rhavkllsvl nqmpqrhgpd tffnfpgcsa
      241 aaialppiak wpyqngftln twfrmdplnn invdkdkpyl ycfrtskgvg ysahfvgncl
      301 ivtslkskgk gfqhcvkydf qprkwymisi vhiynrwrns eircyvngql vsygdmawhv
      361 ntndsydkcf lgssetadan rvfcgqlgav yvfsealnpa qifaihqlgp gykstfkfks
      421 esdihlaehh kqvlydgkla ssiaftynak atdaqlcles spkenasifv hsphalmlqd
      481 vkaivthsih saihsiggiq vlfplfaqld nrqlndsqve ttvcatllaf lvellkssva
      541 mqeqmlggkg flvigyllek ssrvhitrav leqflsfaky ldglshgapl lkqlcdhilf
      601 npaiwihtpa kvqlslytyl saefigtati yttirrvgtv lqlmhtlkyy ywvinpadss
      661 gitpkgldgp rpsqkeiisl rafmllflkq lilkdrgvke delqsilnyl ltmhedenih
      721 dvlqllvalm sehpasmipa fdqrngirvi ykllaskses iwvqalkvlg yflkhlghkr
      781 kveimhthsl ftllgerlml htntvtvtty ntlyeilteq vctqvvhkph pepdstvkiq
      841 npmilkvvat llknstpsae lmevrrlfls dmiklfsnsr enrrcllqcs vwqdwmfslg
      901 yinpknseeq kitemvynif rillyhaiky ewggwrvwvd tlsiahskvt yeahkeylak
      961 myeeyqrqee enikkgkkgn vstisglssq ttgakggmei reiedlsqsq spesetdypv
     1021 stdtrdllms tkvsddilgn sdrpgsgvhv evhdllvdik aekveatevk lddmdlspet
     1081 lvggengalv eveslldnvy saaveklqnn vhgsvgiikk neekdngpli tladekedlp
     1141 nsstsflfdk ipkqeekllp elssnhiipn iqdtqvhlgv sddlgllahm tgsvdltcts
     1201 siieekefki httsdgmssi serdlasstk gleyaemtat tletessssk ivpnidagsi
     1261 isdtersddg kesgkeirki qtttttqavq grsitqqdrd lrvdlgfrgm pmteeqrrqf
     1321 spgprttmfr ipefkwspmh qrlltdllfa letdvhvwrs hstksvmdfv nsneniifvh
     1381 ntihlisqmv dniiiacggi lpllsaatsp ttelenievt qgmsaetavt flsrlmamvd
     1441 vlvfasslnf seieaeknms sgglmrqclr lvccvavrnc lecrqrqrdr gnksshgssk
     1501 pqevpqsvta taasktplen vpgnlspikd pdrllqdvdi nrlravvfrd vddskqaqfl
     1561 alavvyfisv lmvskyrdil epqrettrtg sqpgrnirqe insptstvvv ipsiphpsln
     1621 hgflaklipe qsfghsfyke tpaafpdtik eketptpged iqvessipht dsgigeeqva
     1681 silngaelet stgpdamsel lstlssevkk sqesltenps etlkpatsis sisqtkginv
     1741 keilkslvaa pveiaecgpe pipypdpalk retqailpmq fhsfdrsvvv pvkkpppgsl
     1801 avttvgatta gsglptgsts nifaatgatp ksavdsgsss ssssssfvng atsknlpavq
     1861 tvapmpedsa enmsitakle ralekvapll reifvdfapf lsrtllgshg qellieglvc
     1921 mksstsvvel vmllcsqewq nsiqknagla fielinegrl lchamkdhiv rvaneaefil
     1981 nrqraedvhk haefesqcaq yaadrreeek mcdhlisaak hrdhvtanql kqkilniltn
     2041 khgawgavsh sqlhdfwrld yweddlrrrr rfvrnafgst haeallkaai eygteedvvk
     2101 skktfrsqai vnqnaetelm legdddavsl lqekeidnla gpvvlstpaq liapvvvakg
     2161 tlsittteiy fevdeddsaf kkidtkvlay teglhgkwmf seiravfsrr yllqntalev
     2221 fmanrtsvmf nfpdqatvkk vvyslprvgv gtsyglpqar rislatprql ykssnmtqrw
     2281 qrreisnfey lmflntiagr tyndlnqypv fpwvltnyes eeldltlpgn frdlskpiga
     2341 lnpkravfya eryetweddq sppyhynthy statstlswl vriepfttff lnandgkfdh
     2401 pdrtfssvar swrtsqrdts dvkelipefy ylpemfvnsn gynlgvrede vvvndvdlpp
     2461 wakkpedfvr inrmalesef vscqlhqwid lifgykqrgp eavralnvfh yltyegsvnl
     2521 dsitdpvlre ipeayfirdp htflltkdfi kameaqiqnf gqtpsqllie phpprssamh
     2581 lcflpqsplm fkdqmqqdvi mvlkfpsnsp vthvaantlp hltipavvtv tcsrlfavnr
     2641 whntvglrga pgysldqahh lpiemdplia nnsgvnkrqi tdlvdqsiqi nahcfvvtad
     2701 nryilicgfw dksfrvyste tgkltqivfg hwdvvtclar sesyiggdcy ivsgsrdatl
     2761 llwywsgrhh iigdnpnssd ypapravltg hdhevvcvsv caelglvisg akegpclvht
     2821 itgdllrale gpenclfprl isvsseghci iyyergrfsn fsingkllaq meindstrai
     2881 llssdgqnlv tggdngvvev wqacdfkqly iypgcdagir amdlshdqrt litgmasgsi
     2941 vafnidfnrw hyehqnry
//
LOCUS       XP_006719869            2943 aa            linear   PRI 05-AUG-2025
DEFINITION  neurobeachin isoform X4 [Homo sapiens].
ACCESSION   XP_006719869
VERSION     XP_006719869.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006719806.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2943
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..2943
                     /product="neurobeachin isoform X4"
                     /calculated_mol_wt=327420
     Region          255..402
                     /region_name="Laminin_G_3"
                     /note="Concanavalin A-like lectin/glucanases superfamily;
                     pfam13385"
                     /db_xref="CDD:463865"
     Region          467..947
                     /region_name="DUF4704"
                     /note="Neurobeachin/BDCP, DUF4704 alpha solenoid region;
                     pfam15787"
                     /db_xref="CDD:464870"
     Region          1963..2129
                     /region_name="DUF1088"
                     /note="Neurobeachin-like, DUF1088; pfam06469"
                     /db_xref="CDD:461925"
     Region          2155..2252
                     /region_name="PH_BEACH"
                     /note="PH domain associated with Beige/BEACH; pfam14844"
                     /db_xref="CDD:434260"
     Region          2284..2560
                     /region_name="Beach"
                     /note="Beige/BEACH domain; pfam02138"
                     /db_xref="CDD:460459"
     Region          2660..2932
                     /region_name="NBCH_WD40"
                     /note="Neurobeachin beta propeller domain; pfam20426"
                     /db_xref="CDD:466575"
     Region          2721..2775
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2780..2815
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2820..2849
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2858..2896
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2904..2930
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..2943
                     /gene="NBEA"
                     /gene_synonym="BCL8B; LYST2; NEDEGE"
                     /coded_by="XM_006719806.4:552..9383"
                     /db_xref="GeneID:26960"
                     /db_xref="HGNC:HGNC:7648"
                     /db_xref="MIM:604889"
ORIGIN      
        1 masekpgpgp glepqpvgli avgaaggggg gsggggtggs gmgelrgasg sgsvmlpagm
       61 inpsvpirni rmkfavligl iqvgevsnrd ivetvlnllv ggefdlemnf iiqdaesitc
      121 mtellehcdv tcqaeiwsmf tailrksvrn lqtstevgli eqvllkmsav ddmiadllvd
      181 mlgvlasysi tvkelkllfs mlrgesgiwp rhavkllsvl nqmpqrhgpd tffnfpgcsa
      241 aaialppiak wpyqngftln twfrmdplnn invdkdkpyl ycfrtskgvg ysahfvgncl
      301 ivtslkskgk gfqhcvkydf qprkwymisi vhiynrwrns eircyvngql vsygdmawhv
      361 ntndsydkcf lgssetadan rvfcgqlgav yvfsealnpa qifaihqlgp gykstfkfks
      421 esdihlaehh kqvlydgkla ssiaftynak atdaqlcles spkenasifv hsphalmlqd
      481 vkaivthsih saihsiggiq vlfplfaqld nrqlndsqve ttvcatllaf lvellkssva
      541 mqeqmlggkg flvigyllek ssrvhitrav leqflsfaky ldglshgapl lkqlcdhilf
      601 npaiwihtpa kvqlslytyl saefigtati yttirrvgtv lqlmhtlkyy ywvinpadss
      661 gitpkgldgp rpsqkeiisl rafmllflkq lilkdrgvke delqsilnyl ltmhedenih
      721 dvlqllvalm sehpasmipa fdqrngirvi ykllaskses iwvqalkvlg yflkhlghkr
      781 kveimhthsl ftllgerlml htntvtvtty ntlyeilteq vctqvvhkph pepdstvkiq
      841 npmilkvvat llknstpsae lmevrrlfls dmiklfsnsr enrrcllqcs vwqdwmfslg
      901 yinpknseeq kitemvynif rillyhaiky ewggwrvwvd tlsiahskvt yeahkeylak
      961 myeeyqrqee enikkgkkgn vstisglssq ttgakggmei reiedlsqsq spesetdypv
     1021 stdtrdllms tkvsddilgn sdrpgsgvhv evhdllvdik aekveatevk lddmdlspet
     1081 lvggengalv eveslldnvy saaveklqnn vhgsvgiikk neekdngpli tladekedlp
     1141 nsstsflfdk ipkqeekllp elssnhiipn iqdtqvhlgv sddlgllahm tgsvdltcts
     1201 siieekefki httsdgmssi serdlasstk gleyaemtat tletessssk ivpnidagsi
     1261 isdtersddg kesgkeirki qtttttqavq grsitqqdrd lrvdlgfrgm pmteeqrrqf
     1321 spgprttmfr ipefkwspmh qrlltdllfa letdvhvwrs hstksvmdfv nsneniifvh
     1381 ntihlisqmv dniiiacggi lpllsaatsp ttelenievt qgmsaetavt flsrlmamvd
     1441 vlvfasslnf seieaeknms sgglmrqclr lvccvavrnc lecrqrqrdr gnksshgssk
     1501 pqevpqsvta taasktplen vpgnlspikd pdrllqdvdi nrlravvfrd vddskqaqfl
     1561 alavvyfisv lmvskyrdil epqrettrtg sqpgrnirqe insptstvvv ipsiphpsln
     1621 hgflaklipe qsfghsfyke tpaafpdtik eketptpged iqvessipht dsgigeeqva
     1681 silngaelet stgpdamsel lstlssevkk sqesltenps etlkpatsis sisqtkginv
     1741 keilkslvaa pveiaecgpe pipypdpalk retqailpmq fhsfdrsvvv pvkkpppgsl
     1801 avttvgatta gsglptgsts nifaatgatp ksminttgav dsgsssssss ssfvngatsk
     1861 nlpavqtvap mpedsaenms itaklerale kvapllreif vdfapflsrt llgshgqell
     1921 ieglvcmkss tsvvelvmll csqewqnsiq knaglafiel inegrllcha mkdhivrvan
     1981 eaefilnrqr aedvhkhaef esqcaqyaad rreeekmcdh lisaakhrdh vtanqlkqki
     2041 lniltnkhga wgavshsqlh dfwrldywed dlrrrrrfvr nafgsthaea llkaaieygt
     2101 eedvvkskkt frsqaivnqn aetelmlegd ddavsllqek eidnlagpvv lstpaqliap
     2161 vvvakgtlsi ttteiyfevd eddsafkkid tkvlaytegl hgkwmfseir avfsrryllq
     2221 ntalevfman rtsvmfnfpd qatvkkvvys lprvgvgtsy glpqarrisl atprqlykss
     2281 nmtqrwqrre isnfeylmfl ntiagrtynd lnqypvfpwv ltnyeseeld ltlpgnfrdl
     2341 skpigalnpk ravfyaerye tweddqsppy hynthystat stlswlvrie pfttfflnan
     2401 dgkfdhpdrt fssvarswrt sqrdtsdvke lipefyylpe mfvnsngynl gvredevvvn
     2461 dvdlppwakk pedfvrinrm alesefvscq lhqwidlifg ykqrgpeavr alnvfhylty
     2521 egsvnldsit dpvlreamea qiqnfgqtps qlliephppr ssamhlcflp qsplmfkdqm
     2581 qqdvimvlkf psnspvthva antlphltip avvtvtcsrl favnrwhntv glrgapgysl
     2641 dqahhlpiem dpliannsgv nkrqitdlvd qsiqinahcf vvtadnryil icgfwdksfr
     2701 vystetgklt qivfghwdvv tclarsesyi ggdcyivsgs rdatlllwyw sgrhhiigdn
     2761 pnssdypapr avltghdhev vcvsvcaelg lvisgakegp clvhtitgdl lralegpenc
     2821 lfprlisvss eghciiyyer grfsnfsing kllaqmeind straillssd gqnlvtggdn
     2881 gvvevwqacd fkqlyiypgc dagiramdls hdqrtlitgm asgsivafni dfnrwhyehq
     2941 nry
//
LOCUS       XP_005266403            2941 aa            linear   PRI 05-AUG-2025
DEFINITION  neurobeachin isoform X5 [Homo sapiens].
ACCESSION   XP_005266403
VERSION     XP_005266403.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266346.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2941
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..2941
                     /product="neurobeachin isoform X5"
                     /calculated_mol_wt=327103
     Region          255..402
                     /region_name="Laminin_G_3"
                     /note="Concanavalin A-like lectin/glucanases superfamily;
                     pfam13385"
                     /db_xref="CDD:463865"
     Region          467..947
                     /region_name="DUF4704"
                     /note="Neurobeachin/BDCP, DUF4704 alpha solenoid region;
                     pfam15787"
                     /db_xref="CDD:464870"
     Region          1966..2132
                     /region_name="DUF1088"
                     /note="Neurobeachin-like, DUF1088; pfam06469"
                     /db_xref="CDD:461925"
     Region          2158..2255
                     /region_name="PH_BEACH"
                     /note="PH domain associated with Beige/BEACH; pfam14844"
                     /db_xref="CDD:434260"
     Region          2287..2563
                     /region_name="Beach"
                     /note="Beige/BEACH domain; pfam02138"
                     /db_xref="CDD:460459"
     Region          2658..2930
                     /region_name="NBCH_WD40"
                     /note="Neurobeachin beta propeller domain; pfam20426"
                     /db_xref="CDD:466575"
     Region          2719..2773
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2778..2813
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2818..2847
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2856..2894
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2902..2928
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..2941
                     /gene="NBEA"
                     /gene_synonym="BCL8B; LYST2; NEDEGE"
                     /coded_by="XM_005266346.5:552..9377"
                     /db_xref="GeneID:26960"
                     /db_xref="HGNC:HGNC:7648"
                     /db_xref="MIM:604889"
ORIGIN      
        1 masekpgpgp glepqpvgli avgaaggggg gsggggtggs gmgelrgasg sgsvmlpagm
       61 inpsvpirni rmkfavligl iqvgevsnrd ivetvlnllv ggefdlemnf iiqdaesitc
      121 mtellehcdv tcqaeiwsmf tailrksvrn lqtstevgli eqvllkmsav ddmiadllvd
      181 mlgvlasysi tvkelkllfs mlrgesgiwp rhavkllsvl nqmpqrhgpd tffnfpgcsa
      241 aaialppiak wpyqngftln twfrmdplnn invdkdkpyl ycfrtskgvg ysahfvgncl
      301 ivtslkskgk gfqhcvkydf qprkwymisi vhiynrwrns eircyvngql vsygdmawhv
      361 ntndsydkcf lgssetadan rvfcgqlgav yvfsealnpa qifaihqlgp gykstfkfks
      421 esdihlaehh kqvlydgkla ssiaftynak atdaqlcles spkenasifv hsphalmlqd
      481 vkaivthsih saihsiggiq vlfplfaqld nrqlndsqve ttvcatllaf lvellkssva
      541 mqeqmlggkg flvigyllek ssrvhitrav leqflsfaky ldglshgapl lkqlcdhilf
      601 npaiwihtpa kvqlslytyl saefigtati yttirrvgtv lqlmhtlkyy ywvinpadss
      661 gitpkgldgp rpsqkeiisl rafmllflkq lilkdrgvke delqsilnyl ltmhedenih
      721 dvlqllvalm sehpasmipa fdqrngirvi ykllaskses iwvqalkvlg yflkhlghkr
      781 kveimhthsl ftllgerlml htntvtvtty ntlyeilteq vctqvvhkph pepdstvkiq
      841 npmilkvvat llknstpsae lmevrrlfls dmiklfsnsr enrrcllqcs vwqdwmfslg
      901 yinpknseeq kitemvynif rillyhaiky ewggwrvwvd tlsiahskvt yeahkeylak
      961 myeeyqrqee enikkgkkgn vstisglssq ttgakggmei reiedlsqsq spesetdypv
     1021 stdtrdllms tkvsddilgn sdrpgsgvhv evhdllvdik aekveatevk lddmdlspet
     1081 lvggengalv eveslldnvy saaveklqnn vhgsvgiikk neekdngpli tladekedlp
     1141 nsstsflfdk ipkqeekllp elssnhiipn iqdtqvhlgv sddlgllahm tgsvdltcts
     1201 siieekefki httsdgmssi serdlasstk gleyaemtat tletessssk ivpnidagsi
     1261 isdtersddg kesgkeirki qtttttqavq grsitqqdrd lrvdlgfrgm pmteeqrrqf
     1321 spgprttmfr ipefkwspmh qrlltdllfa letdvhvwrs hstksvmdfv nsneniifvh
     1381 ntihlisqmv dniiiacggi lpllsaatsp tgskteleni evtqgmsaet avtflsrlma
     1441 mvdvlvfass lnfseieaek nmssgglmrq clrlvccvav rnclecrqrq rdrgnksshg
     1501 sskpqevpqs vtataasktp lenvpgnlsp ikdpdrllqd vdinrlravv frdvddskqa
     1561 qflalavvyf isvlmvskyr dilepqrett rtgsqpgrni rqeinsptst vvvipsiphp
     1621 slnhgflakl ipeqsfghsf yketpaafpd tikeketptp gediqvessi phtdsgigee
     1681 qvasilngae letstgpdam sellstlsse vkksqeslte npsetlkpat sissisqtkg
     1741 invkeilksl vaapveiaec gpepipypdp alkretqail pmqfhsfdrs vvvpvkkppp
     1801 gslavttvga ttagsglptg stsnifaatg atpksmintt gavdsgssss sssssfvnga
     1861 tsknlpavqt vapmpedsae nmsitakler alekvapllr eifvdfapfl srtllgshgq
     1921 ellieglvcm ksstsvvelv mllcsqewqn siqknaglaf ielinegrll chamkdhivr
     1981 vaneaefiln rqraedvhkh aefesqcaqy aadrreeekm cdhlisaakh rdhvtanqlk
     2041 qkilniltnk hgawgavshs qlhdfwrldy weddlrrrrr fvrnafgsth aeallkaaie
     2101 ygteedvvks kktfrsqaiv nqnaetelml egdddavsll qekeidnlag pvvlstpaql
     2161 iapvvvakgt lsittteiyf evdeddsafk kidtkvlayt eglhgkwmfs eiravfsrry
     2221 llqntalevf manrtsvmfn fpdqatvkkv vyslprvgvg tsyglpqarr islatprqly
     2281 kssnmtqrwq rreisnfeyl mflntiagrt yndlnqypvf pwvltnyese eldltlpgnf
     2341 rdlskpigal npkravfyae ryetweddqs ppyhynthys tatstlswlv riepfttffl
     2401 nandgkfdhp drtfssvars wrtsqrdtsd vkelipefyy lpemfvnsng ynlgvredev
     2461 vvndvdlppw akkpedfvri nrmalesefv scqlhqwidl ifgykqrgpe avralnvfhy
     2521 ltyegsvnld sitdpvlrea meaqiqnfgq tpsqllieph pprssamhls plmfkdqmqq
     2581 dvimvlkfps nspvthvaan tlphltipav vtvtcsrlfa vnrwhntvgl rgapgysldq
     2641 ahhlpiemdp liannsgvnk rqitdlvdqs iqinahcfvv tadnryilic gfwdksfrvy
     2701 stetgkltqi vfghwdvvtc larsesyigg dcyivsgsrd atlllwywsg rhhiigdnpn
     2761 ssdypaprav ltghdhevvc vsvcaelglv isgakegpcl vhtitgdllr alegpenclf
     2821 prlisvsseg hciiyyergr fsnfsingkl laqmeindst raillssdgq nlvtggdngv
     2881 vevwqacdfk qlyiypgcda giramdlshd qrtlitgmas gsivafnidf nrwhyehqnr
     2941 y
//
LOCUS       XP_016876034            2940 aa            linear   PRI 05-AUG-2025
DEFINITION  neurobeachin isoform X6 [Homo sapiens].
ACCESSION   XP_016876034
VERSION     XP_016876034.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020545.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2940
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..2940
                     /product="neurobeachin isoform X6"
                     /calculated_mol_wt=327074
     Region          255..402
                     /region_name="Laminin_G_3"
                     /note="Concanavalin A-like lectin/glucanases superfamily;
                     pfam13385"
                     /db_xref="CDD:463865"
     Region          467..947
                     /region_name="DUF4704"
                     /note="Neurobeachin/BDCP, DUF4704 alpha solenoid region;
                     pfam15787"
                     /db_xref="CDD:464870"
     Region          1960..2126
                     /region_name="DUF1088"
                     /note="Neurobeachin-like, DUF1088; pfam06469"
                     /db_xref="CDD:461925"
     Region          2152..2249
                     /region_name="PH_BEACH"
                     /note="PH domain associated with Beige/BEACH; pfam14844"
                     /db_xref="CDD:434260"
     Region          2281..2557
                     /region_name="Beach"
                     /note="Beige/BEACH domain; pfam02138"
                     /db_xref="CDD:460459"
     Region          2657..2929
                     /region_name="NBCH_WD40"
                     /note="Neurobeachin beta propeller domain; pfam20426"
                     /db_xref="CDD:466575"
     Region          2718..2772
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2777..2812
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2817..2846
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2855..2893
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2901..2927
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..2940
                     /gene="NBEA"
                     /gene_synonym="BCL8B; LYST2; NEDEGE"
                     /coded_by="XM_017020545.2:552..9374"
                     /db_xref="GeneID:26960"
                     /db_xref="HGNC:HGNC:7648"
                     /db_xref="MIM:604889"
ORIGIN      
        1 masekpgpgp glepqpvgli avgaaggggg gsggggtggs gmgelrgasg sgsvmlpagm
       61 inpsvpirni rmkfavligl iqvgevsnrd ivetvlnllv ggefdlemnf iiqdaesitc
      121 mtellehcdv tcqaeiwsmf tailrksvrn lqtstevgli eqvllkmsav ddmiadllvd
      181 mlgvlasysi tvkelkllfs mlrgesgiwp rhavkllsvl nqmpqrhgpd tffnfpgcsa
      241 aaialppiak wpyqngftln twfrmdplnn invdkdkpyl ycfrtskgvg ysahfvgncl
      301 ivtslkskgk gfqhcvkydf qprkwymisi vhiynrwrns eircyvngql vsygdmawhv
      361 ntndsydkcf lgssetadan rvfcgqlgav yvfsealnpa qifaihqlgp gykstfkfks
      421 esdihlaehh kqvlydgkla ssiaftynak atdaqlcles spkenasifv hsphalmlqd
      481 vkaivthsih saihsiggiq vlfplfaqld nrqlndsqve ttvcatllaf lvellkssva
      541 mqeqmlggkg flvigyllek ssrvhitrav leqflsfaky ldglshgapl lkqlcdhilf
      601 npaiwihtpa kvqlslytyl saefigtati yttirrvgtv lqlmhtlkyy ywvinpadss
      661 gitpkgldgp rpsqkeiisl rafmllflkq lilkdrgvke delqsilnyl ltmhedenih
      721 dvlqllvalm sehpasmipa fdqrngirvi ykllaskses iwvqalkvlg yflkhlghkr
      781 kveimhthsl ftllgerlml htntvtvtty ntlyeilteq vctqvvhkph pepdstvkiq
      841 npmilkvvat llknstpsae lmevrrlfls dmiklfsnsr enrrcllqcs vwqdwmfslg
      901 yinpknseeq kitemvynif rillyhaiky ewggwrvwvd tlsiahskvt yeahkeylak
      961 myeeyqrqee enikkgkkgn vstisglssq ttgakggmei reiedlsqsq spesetdypv
     1021 stdtrdllms tkvsddilgn sdrpgsgvhv evhdllvdik aekveatevk lddmdlspet
     1081 lvggengalv eveslldnvy saaveklqnn vhgsvgiikk neekdngpli tladekedlp
     1141 nsstsflfdk ipkqeekllp elssnhiipn iqdtqvhlgv sddlgllahm tgsvdltcts
     1201 siieekefki httsdgmssi serdlasstk gleyaemtat tletessssk ivpnidagsi
     1261 isdtersddg kesgkeirki qtttttqavq grsitqqdrd lrvdlgfrgm pmteeqrrqf
     1321 spgprttmfr ipefkwspmh qrlltdllfa letdvhvwrs hstksvmdfv nsneniifvh
     1381 ntihlisqmv dniiiacggi lpllsaatsp tgskteleni evtqgmsaet avtflsrlma
     1441 mvdvlvfass lnfseieaek nmssgglmrq clrlvccvav rnclecrqrq rdrgnksshg
     1501 sskpqevpqs vtataasktp lenvpgnlsp ikdpdrllqd vdinrlravv frdvddskqa
     1561 qflalavvyf isvlmvskyr dilepqrett rtgsqpgrni rqeinsptst vvvipsiphp
     1621 slnhgflakl ipeqsfghsf yketpaafpd tikeketptp gediqvessi phtdsgigee
     1681 qvasilngae letstgpdam sellstlsse vkksqeslte npsetlkpat sissisqtkg
     1741 invkeilksl vaapveiaec gpepipypdp alkretqail pmqfhsfdrs vvvpvkkppp
     1801 gslavttvga ttagsglptg stsnifaatg atpksavdsg sssssssssf vngatsknlp
     1861 avqtvapmpe dsaenmsita kleralekva pllreifvdf apflsrtllg shgqellieg
     1921 lvcmksstsv velvmllcsq ewqnsiqkna glafieline grllchamkd hivrvaneae
     1981 filnrqraed vhkhaefesq caqyaadrre eekmcdhlis aakhrdhvta nqlkqkilni
     2041 ltnkhgawga vshsqlhdfw rldyweddlr rrrrfvrnaf gsthaeallk aaieygteed
     2101 vvkskktfrs qaivnqnaet elmlegddda vsllqekeid nlagpvvlst paqliapvvv
     2161 akgtlsittt eiyfevdedd safkkidtkv layteglhgk wmfseiravf srryllqnta
     2221 levfmanrts vmfnfpdqat vkkvvyslpr vgvgtsyglp qarrislatp rqlykssnmt
     2281 qrwqrreisn feylmflnti agrtyndlnq ypvfpwvltn yeseeldltl pgnfrdlskp
     2341 igalnpkrav fyaeryetwe ddqsppyhyn thystatstl swlvriepft tfflnandgk
     2401 fdhpdrtfss varswrtsqr dtsdvkelip efyylpemfv nsngynlgvr edevvvndvd
     2461 lppwakkped fvrinrmale sefvscqlhq widlifgykq rgpeavraln vfhyltyegs
     2521 vnldsitdpv lreameaqiq nfgqtpsqll iephpprssa mhlcflpqsp lmfkdqmqqd
     2581 vimvlkfpsn spvthvaant lphltipavv tvtcsrlfav nrwhntvglr gapgysldqa
     2641 hhlpiemdpl iannsgvnkr qitdlvdqsi qinahcfvvt adnryilicg fwdksfrvys
     2701 tetgkltqiv fghwdvvtcl arsesyiggd cyivsgsrda tlllwywsgr hhiigdnpns
     2761 sdypapravl tghdhevvcv svcaelglvi sgakegpclv htitgdllra legpenclfp
     2821 rlisvssegh ciiyyergrf snfsingkll aqmeindstr aillssdgqn lvtggdngvv
     2881 evwqacdfkq lyiypgcdag iramdlshdq rtlitgmasg sivafnidfn rwhyehqnry
//
LOCUS       XP_006719868            2938 aa            linear   PRI 05-AUG-2025
DEFINITION  neurobeachin isoform X7 [Homo sapiens].
ACCESSION   XP_006719868
VERSION     XP_006719868.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006719805.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2938
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..2938
                     /product="neurobeachin isoform X7"
                     /calculated_mol_wt=326831
     Region          255..402
                     /region_name="Laminin_G_3"
                     /note="Concanavalin A-like lectin/glucanases superfamily;
                     pfam13385"
                     /db_xref="CDD:463865"
     Region          467..947
                     /region_name="DUF4704"
                     /note="Neurobeachin/BDCP, DUF4704 alpha solenoid region;
                     pfam15787"
                     /db_xref="CDD:464870"
     Region          1963..2129
                     /region_name="DUF1088"
                     /note="Neurobeachin-like, DUF1088; pfam06469"
                     /db_xref="CDD:461925"
     Region          2155..2252
                     /region_name="PH_BEACH"
                     /note="PH domain associated with Beige/BEACH; pfam14844"
                     /db_xref="CDD:434260"
     Region          2284..2560
                     /region_name="Beach"
                     /note="Beige/BEACH domain; pfam02138"
                     /db_xref="CDD:460459"
     Region          2655..2927
                     /region_name="NBCH_WD40"
                     /note="Neurobeachin beta propeller domain; pfam20426"
                     /db_xref="CDD:466575"
     Region          2716..2770
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2775..2810
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2815..2844
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2853..2891
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2899..2925
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..2938
                     /gene="NBEA"
                     /gene_synonym="BCL8B; LYST2; NEDEGE"
                     /coded_by="XM_006719805.4:552..9368"
                     /db_xref="GeneID:26960"
                     /db_xref="HGNC:HGNC:7648"
                     /db_xref="MIM:604889"
ORIGIN      
        1 masekpgpgp glepqpvgli avgaaggggg gsggggtggs gmgelrgasg sgsvmlpagm
       61 inpsvpirni rmkfavligl iqvgevsnrd ivetvlnllv ggefdlemnf iiqdaesitc
      121 mtellehcdv tcqaeiwsmf tailrksvrn lqtstevgli eqvllkmsav ddmiadllvd
      181 mlgvlasysi tvkelkllfs mlrgesgiwp rhavkllsvl nqmpqrhgpd tffnfpgcsa
      241 aaialppiak wpyqngftln twfrmdplnn invdkdkpyl ycfrtskgvg ysahfvgncl
      301 ivtslkskgk gfqhcvkydf qprkwymisi vhiynrwrns eircyvngql vsygdmawhv
      361 ntndsydkcf lgssetadan rvfcgqlgav yvfsealnpa qifaihqlgp gykstfkfks
      421 esdihlaehh kqvlydgkla ssiaftynak atdaqlcles spkenasifv hsphalmlqd
      481 vkaivthsih saihsiggiq vlfplfaqld nrqlndsqve ttvcatllaf lvellkssva
      541 mqeqmlggkg flvigyllek ssrvhitrav leqflsfaky ldglshgapl lkqlcdhilf
      601 npaiwihtpa kvqlslytyl saefigtati yttirrvgtv lqlmhtlkyy ywvinpadss
      661 gitpkgldgp rpsqkeiisl rafmllflkq lilkdrgvke delqsilnyl ltmhedenih
      721 dvlqllvalm sehpasmipa fdqrngirvi ykllaskses iwvqalkvlg yflkhlghkr
      781 kveimhthsl ftllgerlml htntvtvtty ntlyeilteq vctqvvhkph pepdstvkiq
      841 npmilkvvat llknstpsae lmevrrlfls dmiklfsnsr enrrcllqcs vwqdwmfslg
      901 yinpknseeq kitemvynif rillyhaiky ewggwrvwvd tlsiahskvt yeahkeylak
      961 myeeyqrqee enikkgkkgn vstisglssq ttgakggmei reiedlsqsq spesetdypv
     1021 stdtrdllms tkvsddilgn sdrpgsgvhv evhdllvdik aekveatevk lddmdlspet
     1081 lvggengalv eveslldnvy saaveklqnn vhgsvgiikk neekdngpli tladekedlp
     1141 nsstsflfdk ipkqeekllp elssnhiipn iqdtqvhlgv sddlgllahm tgsvdltcts
     1201 siieekefki httsdgmssi serdlasstk gleyaemtat tletessssk ivpnidagsi
     1261 isdtersddg kesgkeirki qtttttqavq grsitqqdrd lrvdlgfrgm pmteeqrrqf
     1321 spgprttmfr ipefkwspmh qrlltdllfa letdvhvwrs hstksvmdfv nsneniifvh
     1381 ntihlisqmv dniiiacggi lpllsaatsp ttelenievt qgmsaetavt flsrlmamvd
     1441 vlvfasslnf seieaeknms sgglmrqclr lvccvavrnc lecrqrqrdr gnksshgssk
     1501 pqevpqsvta taasktplen vpgnlspikd pdrllqdvdi nrlravvfrd vddskqaqfl
     1561 alavvyfisv lmvskyrdil epqrettrtg sqpgrnirqe insptstvvv ipsiphpsln
     1621 hgflaklipe qsfghsfyke tpaafpdtik eketptpged iqvessipht dsgigeeqva
     1681 silngaelet stgpdamsel lstlssevkk sqesltenps etlkpatsis sisqtkginv
     1741 keilkslvaa pveiaecgpe pipypdpalk retqailpmq fhsfdrsvvv pvkkpppgsl
     1801 avttvgatta gsglptgsts nifaatgatp ksminttgav dsgsssssss ssfvngatsk
     1861 nlpavqtvap mpedsaenms itaklerale kvapllreif vdfapflsrt llgshgqell
     1921 ieglvcmkss tsvvelvmll csqewqnsiq knaglafiel inegrllcha mkdhivrvan
     1981 eaefilnrqr aedvhkhaef esqcaqyaad rreeekmcdh lisaakhrdh vtanqlkqki
     2041 lniltnkhga wgavshsqlh dfwrldywed dlrrrrrfvr nafgsthaea llkaaieygt
     2101 eedvvkskkt frsqaivnqn aetelmlegd ddavsllqek eidnlagpvv lstpaqliap
     2161 vvvakgtlsi ttteiyfevd eddsafkkid tkvlaytegl hgkwmfseir avfsrryllq
     2221 ntalevfman rtsvmfnfpd qatvkkvvys lprvgvgtsy glpqarrisl atprqlykss
     2281 nmtqrwqrre isnfeylmfl ntiagrtynd lnqypvfpwv ltnyeseeld ltlpgnfrdl
     2341 skpigalnpk ravfyaerye tweddqsppy hynthystat stlswlvrie pfttfflnan
     2401 dgkfdhpdrt fssvarswrt sqrdtsdvke lipefyylpe mfvnsngynl gvredevvvn
     2461 dvdlppwakk pedfvrinrm alesefvscq lhqwidlifg ykqrgpeavr alnvfhylty
     2521 egsvnldsit dpvlreamea qiqnfgqtps qlliephppr ssamhlsplm fkdqmqqdvi
     2581 mvlkfpsnsp vthvaantlp hltipavvtv tcsrlfavnr whntvglrga pgysldqahh
     2641 lpiemdplia nnsgvnkrqi tdlvdqsiqi nahcfvvtad nryilicgfw dksfrvyste
     2701 tgkltqivfg hwdvvtclar sesyiggdcy ivsgsrdatl llwywsgrhh iigdnpnssd
     2761 ypapravltg hdhevvcvsv caelglvisg akegpclvht itgdllrale gpenclfprl
     2821 isvsseghci iyyergrfsn fsingkllaq meindstrai llssdgqnlv tggdngvvev
     2881 wqacdfkqly iypgcdagir amdlshdqrt litgmasgsi vafnidfnrw hyehqnry
//
LOCUS       XP_047286227            2860 aa            linear   PRI 05-AUG-2025
DEFINITION  neurobeachin isoform X8 [Homo sapiens].
ACCESSION   XP_047286227
VERSION     XP_047286227.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430271.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 9% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2860
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..2860
                     /product="neurobeachin isoform X8"
                     /calculated_mol_wt=319932
     Region          148..295
                     /region_name="Laminin_G_3"
                     /note="Concanavalin A-like lectin/glucanases superfamily;
                     pfam13385"
                     /db_xref="CDD:463865"
     Region          360..840
                     /region_name="DUF4704"
                     /note="Neurobeachin/BDCP, DUF4704 alpha solenoid region;
                     pfam15787"
                     /db_xref="CDD:464870"
     Region          1859..2025
                     /region_name="DUF1088"
                     /note="Neurobeachin-like, DUF1088; pfam06469"
                     /db_xref="CDD:461925"
     Region          2051..2148
                     /region_name="PH_BEACH"
                     /note="PH domain associated with Beige/BEACH; pfam14844"
                     /db_xref="CDD:434260"
     Region          2180..2477
                     /region_name="Beach"
                     /note="Beige/BEACH domain; pfam02138"
                     /db_xref="CDD:460459"
     Region          2577..2849
                     /region_name="NBCH_WD40"
                     /note="Neurobeachin beta propeller domain; pfam20426"
                     /db_xref="CDD:466575"
     Region          2638..2692
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2697..2732
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2737..2766
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2775..2813
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2821..2847
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..2860
                     /gene="NBEA"
                     /gene_synonym="BCL8B; LYST2; NEDEGE"
                     /coded_by="XM_047430271.1:995..9577"
                     /db_xref="GeneID:26960"
                     /db_xref="HGNC:HGNC:7648"
                     /db_xref="MIM:604889"
ORIGIN      
        1 mnfiiqdaes itcmtelleh cdvtcqaeiw smftailrks vrnlqtstev glieqvllkm
       61 savddmiadl lvdmlgvlas ysitvkelkl lfsmlrgesg iwprhavkll svlnqmpqrh
      121 gpdtffnfpg csaaaialpp iakwpyqngf tlntwfrmdp lnninvdkdk pylycfrtsk
      181 gvgysahfvg nclivtslks kgkgfqhcvk ydfqprkwym isivhiynrw rnseircyvn
      241 gqlvsygdma whvntndsyd kcflgsseta danrvfcgql gavyvfseal npaqifaihq
      301 lgpgykstfk fksesdihla ehhkqvlydg klassiafty nakatdaqlc lesspkenas
      361 ifvhsphalm lqdvkaivth sihsaihsig giqvlfplfa qldnrqlnds qvettvcatl
      421 laflvellks svamqeqmlg gkgflvigyl lekssrvhit ravleqflsf akyldglshg
      481 apllkqlcdh ilfnpaiwih tpakvqlsly tylsaefigt atiyttirrv gtvlqlmhtl
      541 kyyywvinpa dssgitpkgl dgprpsqkei islrafmllf lkqlilkdrg vkedelqsil
      601 nylltmhede nihdvlqllv almsehpasm ipafdqrngi rviykllask sesiwvqalk
      661 vlgyflkhlg hkrkveimht hslftllger lmlhtntvtv ttyntlyeil teqvctqvvh
      721 kphpepdstv kiqnpmilkv vatllknstp saelmevrrl flsdmiklfs nsrenrrcll
      781 qcsvwqdwmf slgyinpkns eeqkitemvy nifrillyha ikyewggwrv wvdtlsiahs
      841 kvtyeahkey lakmyeeyqr qeeenikkgk kgnvstisgl ssqttgakgg meireiedls
      901 qsqspesetd ypvstdtrdl lmstkvsddi lgnsdrpgsg vhvevhdllv dikaekveat
      961 evklddmdls petlvggeng alveveslld nvysaavekl qnnvhgsvgi ikkneekdng
     1021 plitladeke dlpnsstsfl fdkipkqeek llpelssnhi ipniqdtqvh lgvsddlgll
     1081 ahmtgsvdlt ctssiieeke fkihttsdgm ssiserdlas stkgleyaem tattletess
     1141 sskivpnida gsiisdters ddgkesgkei rkiqtttttq avqgrsitqq drdlrvdlgf
     1201 rgmpmteeqr rqfspgprtt mfripefkws pmhqrlltdl lfaletdvhv wrshstksvm
     1261 dfvnsnenii fvhntihlis qmvdniiiac ggilpllsaa tsptgsktel enievtqgms
     1321 aetavtflsr lmamvdvlvf asslnfseie aeknmssggl mrqclrlvcc vavrnclecr
     1381 qrqrdrgnks shgsskpqev pqsvtataas ktplenvpgn lspikdpdrl lqdvdinrlr
     1441 avvfrdvdds kqaqflalav vyfisvlmvs kyrdilepqr ettrtgsqpg rnirqeinsp
     1501 tstvvvipsi phpslnhgfl aklipeqsfg hsfyketpaa fpdtikeket ptpgediqve
     1561 ssiphtdsgi geeqvasiln gaeletstgp damsellstl ssevkksqes ltenpsetlk
     1621 patsissisq tkginvkeil kslvaapvei aecgpepipy pdpalkretq ailpmqfhsf
     1681 drsvvvpvkk pppgslavtt vgattagsgl ptgstsnifa atgatpksmi nttgavdsgs
     1741 ssssssssfv ngatsknlpa vqtvapmped saenmsitak leralekvap llreifvdfa
     1801 pflsrtllgs hgqelliegl vcmksstsvv elvmllcsqe wqnsiqknag lafielineg
     1861 rllchamkdh ivrvaneaef ilnrqraedv hkhaefesqc aqyaadrree ekmcdhlisa
     1921 akhrdhvtan qlkqkilnil tnkhgawgav shsqlhdfwr ldyweddlrr rrrfvrnafg
     1981 sthaeallka aieygteedv vkskktfrsq aivnqnaete lmlegdddav sllqekeidn
     2041 lagpvvlstp aqliapvvva kgtlsittte iyfevdedds afkkidtkvl ayteglhgkw
     2101 mfseiravfs rryllqntal evfmanrtsv mfnfpdqatv kkvvyslprv gvgtsyglpq
     2161 arrislatpr qlykssnmtq rwqrreisnf eylmflntia grtyndlnqy pvfpwvltny
     2221 eseeldltlp gnfrdlskpi galnpkravf yaeryetwed dqsppyhynt hystatstls
     2281 wlvriepftt fflnandgkf dhpdrtfssv arswrtsqrd tsdvkelipe fyylpemfvn
     2341 sngynlgvre devvvndvdl ppwakkpedf vrinrmales efvscqlhqw idlifgykqr
     2401 gpeavralnv fhyltyegsv nldsitdpvl reipeayfir dphtflltkd fikameaqiq
     2461 nfgqtpsqll iephpprssa mhlcflpqsp lmfkdqmqqd vimvlkfpsn spvthvaant
     2521 lphltipavv tvtcsrlfav nrwhntvglr gapgysldqa hhlpiemdpl iannsgvnkr
     2581 qitdlvdqsi qinahcfvvt adnryilicg fwdksfrvys tetgkltqiv fghwdvvtcl
     2641 arsesyiggd cyivsgsrda tlllwywsgr hhiigdnpns sdypapravl tghdhevvcv
     2701 svcaelglvi sgakegpclv htitgdllra legpenclfp rlisvssegh ciiyyergrf
     2761 snfsingkll aqmeindstr aillssdgqn lvtggdngvv evwqacdfkq lyiypgcdag
     2821 iramdlshdq rtlitgmasg sivafnidfn rwhyehqnry
//
LOCUS       XP_011533348            2488 aa            linear   PRI 05-AUG-2025
DEFINITION  neurobeachin isoform X9 [Homo sapiens].
ACCESSION   XP_011533348
VERSION     XP_011533348.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535046.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2488
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..2488
                     /product="neurobeachin isoform X9"
                     /calculated_mol_wt=278321
     Region          43..468
                     /region_name="DUF4704"
                     /note="Neurobeachin/BDCP, DUF4704 alpha solenoid region;
                     pfam15787"
                     /db_xref="CDD:464870"
     Region          1487..1653
                     /region_name="DUF1088"
                     /note="Neurobeachin-like, DUF1088; pfam06469"
                     /db_xref="CDD:461925"
     Region          1679..1776
                     /region_name="PH_BEACH"
                     /note="PH domain associated with Beige/BEACH; pfam14844"
                     /db_xref="CDD:434260"
     Region          1808..2105
                     /region_name="Beach"
                     /note="Beige/BEACH domain; pfam02138"
                     /db_xref="CDD:460459"
     Region          2205..2477
                     /region_name="NBCH_WD40"
                     /note="Neurobeachin beta propeller domain; pfam20426"
                     /db_xref="CDD:466575"
     Region          2266..2320
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2325..2360
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2365..2394
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2403..2441
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2449..2475
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..2488
                     /gene="NBEA"
                     /gene_synonym="BCL8B; LYST2; NEDEGE"
                     /coded_by="XM_011535046.2:103..7569"
                     /db_xref="GeneID:26960"
                     /db_xref="HGNC:HGNC:7648"
                     /db_xref="MIM:604889"
ORIGIN      
        1 mtvkwkqlsg eleigkngek fcmavhrilq vycepcnnpm hfsycatlla flvellkssv
       61 amqeqmlggk gflvigylle kssrvhitra vleqflsfak yldglshgap llkqlcdhil
      121 fnpaiwihtp akvqlslyty lsaefigtat iyttirrvgt vlqlmhtlky yywvinpads
      181 sgitpkgldg prpsqkeiis lrafmllflk qlilkdrgvk edelqsilny lltmhedeni
      241 hdvlqllval msehpasmip afdqrngirv iykllaskse siwvqalkvl gyflkhlghk
      301 rkveimhths lftllgerlm lhtntvtvtt yntlyeilte qvctqvvhkp hpepdstvki
      361 qnpmilkvva tllknstpsa elmevrrlfl sdmiklfsns renrrcllqc svwqdwmfsl
      421 gyinpknsee qkitemvyni frillyhaik yewggwrvwv dtlsiahskv tyeahkeyla
      481 kmyeeyqrqe eenikkgkkg nvstisglss qttgakggme ireiedlsqs qspesetdyp
      541 vstdtrdllm stkvsddilg nsdrpgsgvh vevhdllvdi kaekveatev klddmdlspe
      601 tlvggengal veveslldnv ysaaveklqn nvhgsvgiik kneekdngpl itladekedl
      661 pnsstsflfd kipkqeekll pelssnhiip niqdtqvhlg vsddlgllah mtgsvdltct
      721 ssiieekefk ihttsdgmss iserdlasst kgleyaemta ttletessss kivpnidags
      781 iisdtersdd gkesgkeirk iqtttttqav qgrsitqqdr dlrvdlgfrg mpmteeqrrq
      841 fspgprttmf ripefkwspm hqrlltdllf aletdvhvwr shstksvmdf vnsneniifv
      901 hntihlisqm vdniiiacgg ilpllsaats ptgsktelen ievtqgmsae tavtflsrlm
      961 amvdvlvfas slnfseieae knmssgglmr qclrlvccva vrnclecrqr qrdrgnkssh
     1021 gsskpqevpq svtataaskt plenvpgnls pikdpdrllq dvdinrlrav vfrdvddskq
     1081 aqflalavvy fisvlmvsky rdilepqret trtgsqpgrn irqeinspts tvvvipsiph
     1141 pslnhgflak lipeqsfghs fyketpaafp dtikeketpt pgediqvess iphtdsgige
     1201 eqvasilnga eletstgpda msellstlss evkksqeslt enpsetlkpa tsissisqtk
     1261 ginvkeilks lvaapveiae cgpepipypd palkretqai lpmqfhsfdr svvvpvkkpp
     1321 pgslavttvg attagsglpt gstsnifaat gatpksmint tgavdsgsss ssssssfvng
     1381 atsknlpavq tvapmpedsa enmsitakle ralekvapll reifvdfapf lsrtllgshg
     1441 qellieglvc mksstsvvel vmllcsqewq nsiqknagla fielinegrl lchamkdhiv
     1501 rvaneaefil nrqraedvhk haefesqcaq yaadrreeek mcdhlisaak hrdhvtanql
     1561 kqkilniltn khgawgavsh sqlhdfwrld yweddlrrrr rfvrnafgst haeallkaai
     1621 eygteedvvk skktfrsqai vnqnaetelm legdddavsl lqekeidnla gpvvlstpaq
     1681 liapvvvakg tlsittteiy fevdeddsaf kkidtkvlay teglhgkwmf seiravfsrr
     1741 yllqntalev fmanrtsvmf nfpdqatvkk vvyslprvgv gtsyglpqar rislatprql
     1801 ykssnmtqrw qrreisnfey lmflntiagr tyndlnqypv fpwvltnyes eeldltlpgn
     1861 frdlskpiga lnpkravfya eryetweddq sppyhynthy statstlswl vriepfttff
     1921 lnandgkfdh pdrtfssvar swrtsqrdts dvkelipefy ylpemfvnsn gynlgvrede
     1981 vvvndvdlpp wakkpedfvr inrmalesef vscqlhqwid lifgykqrgp eavralnvfh
     2041 yltyegsvnl dsitdpvlre ipeayfirdp htflltkdfi kameaqiqnf gqtpsqllie
     2101 phpprssamh lcflpqsplm fkdqmqqdvi mvlkfpsnsp vthvaantlp hltipavvtv
     2161 tcsrlfavnr whntvglrga pgysldqahh lpiemdplia nnsgvnkrqi tdlvdqsiqi
     2221 nahcfvvtad nryilicgfw dksfrvyste tgkltqivfg hwdvvtclar sesyiggdcy
     2281 ivsgsrdatl llwywsgrhh iigdnpnssd ypapravltg hdhevvcvsv caelglvisg
     2341 akegpclvht itgdllrale gpenclfprl isvsseghci iyyergrfsn fsingkllaq
     2401 meindstrai llssdgqnlv tggdngvvev wqacdfkqly iypgcdagir amdlshdqrt
     2461 litgmasgsi vafnidfnrw hyehqnry
//
LOCUS       XP_011533349            2409 aa            linear   PRI 05-AUG-2025
DEFINITION  neurobeachin isoform X10 [Homo sapiens].
ACCESSION   XP_011533349
VERSION     XP_011533349.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535047.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2409
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..2409
                     /product="neurobeachin isoform X10"
                     /calculated_mol_wt=267431
     Region          255..402
                     /region_name="Laminin_G_3"
                     /note="Concanavalin A-like lectin/glucanases superfamily;
                     pfam13385"
                     /db_xref="CDD:463865"
     Region          467..947
                     /region_name="DUF4704"
                     /note="Neurobeachin/BDCP, DUF4704 alpha solenoid region;
                     pfam15787"
                     /db_xref="CDD:464870"
     Region          1966..2132
                     /region_name="DUF1088"
                     /note="Neurobeachin-like, DUF1088; pfam06469"
                     /db_xref="CDD:461925"
     Region          2158..2255
                     /region_name="PH_BEACH"
                     /note="PH domain associated with Beige/BEACH; pfam14844"
                     /db_xref="CDD:434260"
     Region          2286..>2392
                     /region_name="Beach"
                     /note="BEACH (Beige and Chediak-Higashi) domains,
                     implicated in membrane trafficking, are present in a
                     family of proteins conserved throughout eukaryotes. This
                     group contains human lysosomal trafficking regulator
                     (LYST), LPS-responsive and beige-like anchor...; cl10511"
                     /db_xref="CDD:471984"
     CDS             1..2409
                     /gene="NBEA"
                     /gene_synonym="BCL8B; LYST2; NEDEGE"
                     /coded_by="XM_011535047.3:552..7781"
                     /db_xref="GeneID:26960"
                     /db_xref="HGNC:HGNC:7648"
                     /db_xref="MIM:604889"
ORIGIN      
        1 masekpgpgp glepqpvgli avgaaggggg gsggggtggs gmgelrgasg sgsvmlpagm
       61 inpsvpirni rmkfavligl iqvgevsnrd ivetvlnllv ggefdlemnf iiqdaesitc
      121 mtellehcdv tcqaeiwsmf tailrksvrn lqtstevgli eqvllkmsav ddmiadllvd
      181 mlgvlasysi tvkelkllfs mlrgesgiwp rhavkllsvl nqmpqrhgpd tffnfpgcsa
      241 aaialppiak wpyqngftln twfrmdplnn invdkdkpyl ycfrtskgvg ysahfvgncl
      301 ivtslkskgk gfqhcvkydf qprkwymisi vhiynrwrns eircyvngql vsygdmawhv
      361 ntndsydkcf lgssetadan rvfcgqlgav yvfsealnpa qifaihqlgp gykstfkfks
      421 esdihlaehh kqvlydgkla ssiaftynak atdaqlcles spkenasifv hsphalmlqd
      481 vkaivthsih saihsiggiq vlfplfaqld nrqlndsqve ttvcatllaf lvellkssva
      541 mqeqmlggkg flvigyllek ssrvhitrav leqflsfaky ldglshgapl lkqlcdhilf
      601 npaiwihtpa kvqlslytyl saefigtati yttirrvgtv lqlmhtlkyy ywvinpadss
      661 gitpkgldgp rpsqkeiisl rafmllflkq lilkdrgvke delqsilnyl ltmhedenih
      721 dvlqllvalm sehpasmipa fdqrngirvi ykllaskses iwvqalkvlg yflkhlghkr
      781 kveimhthsl ftllgerlml htntvtvtty ntlyeilteq vctqvvhkph pepdstvkiq
      841 npmilkvvat llknstpsae lmevrrlfls dmiklfsnsr enrrcllqcs vwqdwmfslg
      901 yinpknseeq kitemvynif rillyhaiky ewggwrvwvd tlsiahskvt yeahkeylak
      961 myeeyqrqee enikkgkkgn vstisglssq ttgakggmei reiedlsqsq spesetdypv
     1021 stdtrdllms tkvsddilgn sdrpgsgvhv evhdllvdik aekveatevk lddmdlspet
     1081 lvggengalv eveslldnvy saaveklqnn vhgsvgiikk neekdngpli tladekedlp
     1141 nsstsflfdk ipkqeekllp elssnhiipn iqdtqvhlgv sddlgllahm tgsvdltcts
     1201 siieekefki httsdgmssi serdlasstk gleyaemtat tletessssk ivpnidagsi
     1261 isdtersddg kesgkeirki qtttttqavq grsitqqdrd lrvdlgfrgm pmteeqrrqf
     1321 spgprttmfr ipefkwspmh qrlltdllfa letdvhvwrs hstksvmdfv nsneniifvh
     1381 ntihlisqmv dniiiacggi lpllsaatsp tgskteleni evtqgmsaet avtflsrlma
     1441 mvdvlvfass lnfseieaek nmssgglmrq clrlvccvav rnclecrqrq rdrgnksshg
     1501 sskpqevpqs vtataasktp lenvpgnlsp ikdpdrllqd vdinrlravv frdvddskqa
     1561 qflalavvyf isvlmvskyr dilepqrett rtgsqpgrni rqeinsptst vvvipsiphp
     1621 slnhgflakl ipeqsfghsf yketpaafpd tikeketptp gediqvessi phtdsgigee
     1681 qvasilngae letstgpdam sellstlsse vkksqeslte npsetlkpat sissisqtkg
     1741 invkeilksl vaapveiaec gpepipypdp alkretqail pmqfhsfdrs vvvpvkkppp
     1801 gslavttvga ttagsglptg stsnifaatg atpksmintt gavdsgssss sssssfvnga
     1861 tsknlpavqt vapmpedsae nmsitakler alekvapllr eifvdfapfl srtllgshgq
     1921 ellieglvcm ksstsvvelv mllcsqewqn siqknaglaf ielinegrll chamkdhivr
     1981 vaneaefiln rqraedvhkh aefesqcaqy aadrreeekm cdhlisaakh rdhvtanqlk
     2041 qkilniltnk hgawgavshs qlhdfwrldy weddlrrrrr fvrnafgsth aeallkaaie
     2101 ygteedvvks kktfrsqaiv nqnaetelml egdddavsll qekeidnlag pvvlstpaql
     2161 iapvvvakgt lsittteiyf evdeddsafk kidtkvlayt eglhgkwmfs eiravfsrry
     2221 llqntalevf manrtsvmfn fpdqatvkkv vyslprvgvg tsyglpqarr islatprqly
     2281 kssnmtqrwq rreisnfeyl mflntiagrt yndlnqypvf pwvltnyese eldltlpgnf
     2341 rdlskpigal npkravfyae ryetweddqs ppyhynthys tatstlswlv rilcprhyll
     2401 pineicfgf
//
LOCUS       XP_047286228             739 aa            linear   PRI 05-AUG-2025
DEFINITION  neurobeachin isoform X11 [Homo sapiens].
ACCESSION   XP_047286228
VERSION     XP_047286228.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430272.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..739
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..739
                     /product="neurobeachin isoform X11"
                     /calculated_mol_wt=83870
     Region          <1..48
                     /region_name="PH-like"
                     /note="Pleckstrin homology-like domain; cl17171"
                     /db_xref="CDD:473070"
     Region          80..356
                     /region_name="Beach"
                     /note="Beige/BEACH domain; pfam02138"
                     /db_xref="CDD:460459"
     Region          456..728
                     /region_name="NBCH_WD40"
                     /note="Neurobeachin beta propeller domain; pfam20426"
                     /db_xref="CDD:466575"
     Region          517..571
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          576..611
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          616..645
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          654..692
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          700..726
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..739
                     /gene="NBEA"
                     /gene_synonym="BCL8B; LYST2; NEDEGE"
                     /coded_by="XM_047430272.1:535..2754"
                     /db_xref="GeneID:26960"
                     /db_xref="HGNC:HGNC:7648"
                     /db_xref="MIM:604889"
ORIGIN      
        1 mfseiravfs rryllqntal evfmanrtsv mfnfpdqatv kkvvyslprv gvgtsyglpq
       61 arrislatpr qlykssnmtq rwqrreisnf eylmflntia grtyndlnqy pvfpwvltny
      121 eseeldltlp gnfrdlskpi galnpkravf yaeryetwed dqsppyhynt hystatstls
      181 wlvriepftt fflnandgkf dhpdrtfssv arswrtsqrd tsdvkelipe fyylpemfvn
      241 sngynlgvre devvvndvdl ppwakkpedf vrinrmales efvscqlhqw idlifgykqr
      301 gpeavralnv fhyltyegsv nldsitdpvl reameaqiqn fgqtpsqlli ephpprssam
      361 hlcflpqspl mfkdqmqqdv imvlkfpsns pvthvaantl phltipavvt vtcsrlfavn
      421 rwhntvglrg apgysldqah hlpiemdpli annsgvnkrq itdlvdqsiq inahcfvvta
      481 dnryilicgf wdksfrvyst etgkltqivf ghwdvvtcla rsesyiggdc yivsgsrdat
      541 lllwywsgrh hiigdnpnss dypapravlt ghdhevvcvs vcaelglvis gakegpclvh
      601 titgdllral egpenclfpr lisvsseghc iiyyergrfs nfsingklla qmeindstra
      661 illssdgqnl vtggdngvve vwqacdfkql yiypgcdagi ramdlshdqr tlitgmasgs
      721 ivafnidfnr whyehqnry
//
LOCUS       XP_011533350             435 aa            linear   PRI 05-AUG-2025
DEFINITION  gap junction alpha-3 protein isoform X1 [Homo sapiens].
ACCESSION   XP_011533350
VERSION     XP_011533350.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535048.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..435
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..435
                     /product="gap junction alpha-3 protein isoform X1"
                     /calculated_mol_wt=47279
     Region          3..227
                     /region_name="Connexin"
                     /note="pfam00029"
                     /db_xref="CDD:459638"
     Region          291..435
                     /region_name="Connexin40_C"
                     /note="Connexin 40 C-terminal domain; cl46284"
                     /db_xref="CDD:480624"
     CDS             1..435
                     /gene="GJA3"
                     /gene_synonym="CTRCT14; CX46; CZP3"
                     /coded_by="XM_011535048.3:318..1625"
                     /db_xref="GeneID:2700"
                     /db_xref="HGNC:HGNC:4277"
                     /db_xref="MIM:121015"
ORIGIN      
        1 mgdwsflgrl lenaqehstv igkvwltvlf ifrilvlgaa aedvwgdeqs dftcntqqpg
       61 cenvcydraf pishirfwal qiifvstptl iylghvlhiv rmeekkkere eeeqlkresp
      121 spkeppqdnp ssrddrgrvr magallrtyv fniifktlfe vgfiagqyfl ygfelkplyr
      181 cdrwpcpntv dcfisrptek tifiifmlav acaslllnml eiyhlgwkkl kqgvtsrlgp
      241 daseaplgta dppplppssr ppavaigfpp yyahtaaplg qaravgypga pppaadfkll
      301 alteargkgq saklynghhh llmteqnwan qaaerqppal kaypaastpa apspvgsssp
      361 plaheaeaga apllldgsgs slegsalagt peeeeqavtt aaqmhqpplp lgdpgraska
      421 srassgrarp edlai
//
LOCUS       XP_047286230             337 aa            linear   PRI 05-AUG-2025
DEFINITION  2-oxoglutarate receptor 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047286230
VERSION     XP_047286230.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430274.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..337
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..337
                     /product="2-oxoglutarate receptor 1 isoform X1"
                     /calculated_mol_wt=38120
     Region          34..313
                     /region_name="7tmA_OXGR1"
                     /note="2-oxoglutarate receptor 1, member of the class A
                     family of seven-transmembrane G protein-coupled receptors;
                     cd15375"
                     /db_xref="CDD:320497"
     Region          34..61
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:320497"
     Region          68..93
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320497"
     Site            order(89,92..93,106..111,113..114,117,162,164..168,182,
                     184..186,195,198..200,202..204,206..207,254,257..258,
                     260..261,264,280..281,283..285,288,291..292)
                     /site_type="other"
                     /note="putative ligand binding pocket [chemical binding]"
                     /db_xref="CDD:320497"
     Region          106..136
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320497"
     Region          148..170
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320497"
     Region          195..224
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320497"
     Region          234..264
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320497"
     Region          281..306
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320497"
     CDS             1..337
                     /gene="OXGR1"
                     /gene_synonym="aKGR; CAON2; GPR80; GPR99; P2RY15; P2Y15"
                     /coded_by="XM_047430274.1:296..1309"
                     /db_xref="GeneID:27199"
                     /db_xref="HGNC:HGNC:4531"
                     /db_xref="MIM:606922"
ORIGIN      
        1 mnepldylan asdfpdyaaa fgnctdenip lkmhylpviy giiflvgfpg navvistyif
       61 kmrpwkssti imlnlactdl lyltslpfli hyyasgenwi fgdfmckfir fsfhfnlyss
      121 ilfltcfsif rycviihpms cfsihktrca vvacavvwii slvavipmtf litstnrtnr
      181 sacldltssd elntikwynl iltattfclp lvivtlcytt iihtlthglq tdsclkqkar
      241 rltillllaf yvcflpfhil rviriesrll siscsienqi heayivsrpl aalntfgnll
      301 lyvvvsdnfq qavcstvrck vsgnleqakk isysnnp
//
LOCUS       XP_005266414            1159 aa            linear   PRI 05-AUG-2025
DEFINITION  protocadherin-17 isoform X1 [Homo sapiens].
ACCESSION   XP_005266414
VERSION     XP_005266414.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266357.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1159
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1159
                     /product="protocadherin-17 isoform X1"
                     /calculated_mol_wt=126099
     Region          21..112
                     /region_name="Cadherin_2"
                     /note="Cadherin-like; pfam08266"
                     /db_xref="CDD:462413"
     Region          141..239
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(143..144,202,204,235,237..238)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          247..347
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(254..255,310,312,343,345..346)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          361..468
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(363..364,431,433,464,466..467)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          477..579
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(483..484,541,543,575,577..578)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          594..682
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     CDS             1..1159
                     /gene="PCDH17"
                     /gene_synonym="PCDH68; PCH68"
                     /coded_by="XM_005266357.3:2334..5813"
                     /db_xref="GeneID:27253"
                     /db_xref="HGNC:HGNC:14267"
                     /db_xref="MIM:611760"
ORIGIN      
        1 mylsicccfl lwapaltlkn lnysvpeeqg agtvignigr darlqpglpp aerggggrsk
       61 sgsyrvlens aphlldvdad sgllytkqri dreslcrhna kcqlslevfa ndkeicmikv
      121 eiqdindnap sfssdqiemd isenaapgtr fpltsahdpd agenglrtyl ltrddhglfg
      181 ldvksrgdgt kfpelviqka ldreqqnhht lvltaldgge pprsatvqin vkvidsndns
      241 pvfeapsylv elpenaplgt vvidlnatda degpngevly sfssyvpdrv relfsidpkt
      301 glirvkgnld yeengmleid vqardlgpnp ipahckvtvk lidrndnaps igfvsvrqga
      361 lseaappgtv ialvrvtdrd sgkngqlqcr vlggggtggg gglggpggsv pfkleenydn
      421 fytvvtdrpl dretqdeynv tivardggsp plnstksfai kildendnpp rftkglyvlq
      481 vhennipgey lgsvlaqdpd lgqngtvsys ilpshigdvs iytyvsvnpt ngaiyalrsf
      541 nfeqtkafef kvlakdsgap ahlesnatvr vtvldvndna pvivlptlqn dtaelqvprn
      601 aglgylvstv raldsdfges grltyeivdg nddhlfeidp ssgeirtlhp fwedvtpvve
      661 lvvkvtdhgk ptlsavakli irsvsgslpe gvprvngeqh hwdmslpliv tlstisiill
      721 aamitiavkc krenkeirty ncriaeyshp qlgggkgkkk kinkndimlv qseveernam
      781 nvmnvvssps latspmyfdy qtrlplsspr sevmylkpas nnltvpqgha gchtsftgqg
      841 tnasetpatr msiiqtdnfp aepnymgsrq qfvqssstfk dperaslrds ghgdsdqads
      901 dqdtnkgscc dmsvrealkm kttstksqpl eqepeecvnc tdecrvlghs drcwmpqfpa
      961 anqaenadyr tnlfvptvea nvetetyetv nptgkktfct fgkdkrehti lianvkpylk
     1021 akralspllq evpsassspt kaciepctst kgsldgceak pgalaeassq ylptdsqyls
     1081 pskqprdppf masdqmarvf advhsrasrd ssemgavleq ldhpnrdlgr esvdaeevvr
     1141 eidkllqdcr gndpvavrk
//
LOCUS       XP_047286232            1158 aa            linear   PRI 05-AUG-2025
DEFINITION  protocadherin-17 isoform X2 [Homo sapiens].
ACCESSION   XP_047286232
VERSION     XP_047286232.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430276.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1158
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1158
                     /product="protocadherin-17 isoform X2"
                     /calculated_mol_wt=126012
     Region          21..112
                     /region_name="Cadherin_2"
                     /note="Cadherin-like; pfam08266"
                     /db_xref="CDD:462413"
     Region          141..239
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(143..144,202,204,235,237..238)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          247..347
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(254..255,310,312,343,345..346)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          361..468
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(363..364,431,433,464,466..467)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          477..579
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(483..484,541,543,575,577..578)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          594..682
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     CDS             1..1158
                     /gene="PCDH17"
                     /gene_synonym="PCDH68; PCH68"
                     /coded_by="XM_047430276.1:2334..5810"
                     /db_xref="GeneID:27253"
                     /db_xref="HGNC:HGNC:14267"
                     /db_xref="MIM:611760"
ORIGIN      
        1 mylsicccfl lwapaltlkn lnysvpeeqg agtvignigr darlqpglpp aerggggrsk
       61 sgsyrvlens aphlldvdad sgllytkqri dreslcrhna kcqlslevfa ndkeicmikv
      121 eiqdindnap sfssdqiemd isenaapgtr fpltsahdpd agenglrtyl ltrddhglfg
      181 ldvksrgdgt kfpelviqka ldreqqnhht lvltaldgge pprsatvqin vkvidsndns
      241 pvfeapsylv elpenaplgt vvidlnatda degpngevly sfssyvpdrv relfsidpkt
      301 glirvkgnld yeengmleid vqardlgpnp ipahckvtvk lidrndnaps igfvsvrqga
      361 lseaappgtv ialvrvtdrd sgkngqlqcr vlggggtggg gglggpggsv pfkleenydn
      421 fytvvtdrpl dretqdeynv tivardggsp plnstksfai kildendnpp rftkglyvlq
      481 vhennipgey lgsvlaqdpd lgqngtvsys ilpshigdvs iytyvsvnpt ngaiyalrsf
      541 nfeqtkafef kvlakdsgap ahlesnatvr vtvldvndna pvivlptlqn dtaelqvprn
      601 aglgylvstv raldsdfges grltyeivdg nddhlfeidp ssgeirtlhp fwedvtpvve
      661 lvvkvtdhgk ptlsavakli irsvsgslpe gvprvngeqh hwdmslpliv tlstisiill
      721 aamitiavkc krenkeirty ncriaeyshp qlgggkgkkk kinkndimlv qseveernam
      781 nvmnvvssps latspmyfdy qtrlplsspr sevmylkpas nnltvpqgha gchtsftgqg
      841 tnasetpatr msiiqtdnfp aepnymgsrq qfvqsstfkd peraslrdsg hgdsdqadsd
      901 qdtnkgsccd msvrealkmk ttstksqple qepeecvnct decrvlghsd rcwmpqfpaa
      961 nqaenadyrt nlfvptvean vetetyetvn ptgkktfctf gkdkrehtil ianvkpylka
     1021 kralspllqe vpsasssptk aciepctstk gsldgceakp galaeassqy lptdsqylsp
     1081 skqprdppfm asdqmarvfa dvhsrasrds semgavleql dhpnrdlgre svdaeevvre
     1141 idkllqdcrg ndpvavrk
//
LOCUS       XP_016876036             980 aa            linear   PRI 05-AUG-2025
DEFINITION  protocadherin-17 isoform X3 [Homo sapiens].
ACCESSION   XP_016876036
VERSION     XP_016876036.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020547.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..980
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..980
                     /product="protocadherin-17 isoform X3"
                     /calculated_mol_wt=106455
     Region          21..112
                     /region_name="Cadherin_2"
                     /note="Cadherin-like; pfam08266"
                     /db_xref="CDD:462413"
     Region          141..239
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(143..144,202,204,235,237..238)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          247..347
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(254..255,310,312,343,345..346)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          361..468
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(363..364,431,433,464,466..467)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          477..579
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(483..484,541,543,575,577..578)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          594..682
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     CDS             1..980
                     /gene="PCDH17"
                     /gene_synonym="PCDH68; PCH68"
                     /coded_by="XM_017020547.2:804..3746"
                     /db_xref="GeneID:27253"
                     /db_xref="HGNC:HGNC:14267"
                     /db_xref="MIM:611760"
ORIGIN      
        1 mylsicccfl lwapaltlkn lnysvpeeqg agtvignigr darlqpglpp aerggggrsk
       61 sgsyrvlens aphlldvdad sgllytkqri dreslcrhna kcqlslevfa ndkeicmikv
      121 eiqdindnap sfssdqiemd isenaapgtr fpltsahdpd agenglrtyl ltrddhglfg
      181 ldvksrgdgt kfpelviqka ldreqqnhht lvltaldgge pprsatvqin vkvidsndns
      241 pvfeapsylv elpenaplgt vvidlnatda degpngevly sfssyvpdrv relfsidpkt
      301 glirvkgnld yeengmleid vqardlgpnp ipahckvtvk lidrndnaps igfvsvrqga
      361 lseaappgtv ialvrvtdrd sgkngqlqcr vlggggtggg gglggpggsv pfkleenydn
      421 fytvvtdrpl dretqdeynv tivardggsp plnstksfai kildendnpp rftkglyvlq
      481 vhennipgey lgsvlaqdpd lgqngtvsys ilpshigdvs iytyvsvnpt ngaiyalrsf
      541 nfeqtkafef kvlakdsgap ahlesnatvr vtvldvndna pvivlptlqn dtaelqvprn
      601 aglgylvstv raldsdfges grltyeivdg nddhlfeidp ssgeirtlhp fwedvtpvve
      661 lvvkvtdhgk ptlsavakli irsvsgslpe gvprvngeqh hwdmslpliv tlstisiill
      721 aamitiavkc krenkeirty ncriaeyshp qlgggkgkkk kinkndimlv qseveernam
      781 nvmnvvssps latspmyfdy qtrlplsspr sevmylkpas nnltvpqgha gchtsftgqg
      841 tnasetpatr msiiqtdnfp aepnymgsrq qfvqssstfk dperaslrds ghgdsdqads
      901 dqdtnkgscc dmsvrealkm kttstksqpl eqafptllsf ailtlhtits rlqsvdllpp
      961 geqflhllaf fsviqillvr
//
LOCUS       XP_047286233             812 aa            linear   PRI 05-AUG-2025
DEFINITION  chromosome alignment-maintaining phosphoprotein 1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_047286233
VERSION     XP_047286233.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430277.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..812
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..812
                     /product="chromosome alignment-maintaining phosphoprotein
                     1 isoform X1"
                     /calculated_mol_wt=88968
     Region          <142..645
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          <597..>700
                     /region_name="PTRF_SDPR"
                     /note="PTRF/SDPR family; pfam15237"
                     /db_xref="CDD:464578"
     Site            order(726..727,730..731,734,745,747,751..752,755..756,759,
                     772,774,776,778..779,782..783,785)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          740..760
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          767..786
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..812
                     /gene="CHAMP1"
                     /gene_synonym="C13orf8; CAMP; CHAMP; MRD40; NEDHILD;
                     ZNF828"
                     /coded_by="XM_047430277.1:2045..4483"
                     /db_xref="GeneID:283489"
                     /db_xref="HGNC:HGNC:20311"
                     /db_xref="MIM:616327"
ORIGIN      
        1 meafqelrkp sarlecdhcs frgtdyenvq ihmgtihpef cdemdagglg kmifyqksak
       61 lfhchkcfft skmysnvyyh itskhaspdk wndkpknqln ketdpvkspp lpehqkipcn
      121 saepksipal smetqklgsv lspespkptp ltplepqkpg svvspelqtp lpspepskpa
      181 svsspeppks vpvcesqkla pvpspepqkp apvspesvka tlsnpkpqkq shfpetlgpp
      241 sasspespvl aaspepwgps paaspesrks arttspeprk pspsespepw kpfpavspep
      301 rrpapavspg swkpgppgsp rpwksnpsas sgpwkpakpa psvspgpwkp ipsvspgpwk
      361 ptpsvssasw ksssvspssw ksppaspesw ksgppelrkt aptlspehwk avppvspelr
      421 kpgpplspei rspagspelr kpsgspdlwk lspdqrktsp asldfpesqk ssrggspdlw
      481 kssffiepqk pvfpetrkpg psgpsespka asdiwkpvls idteprkpal fpepaktapp
      541 aspearkral fpeprkhalf pelpksalfs esqkavelgd elqidaiddq kcdilvqeel
      601 laspkklled tlfpsskklk kdnqessdae lssseyiktd ldamdikgqe sssdqeqvdv
      661 esidfskenk mdmtspeqsr nvlqfteeke afiseeeiak ymkrgkgkyy ckicccramk
      721 kgavlhhlvn khnvhspykc ticgkaflle sllknhvaah gqsllkcprc nfesnfprgf
      781 kkhlthcqsr hneeankklm ealeppleeq qi
//
LOCUS       XP_005266417             175 aa            linear   PRI 05-AUG-2025
DEFINITION  G-protein coupled receptor 12 isoform X1 [Homo sapiens].
ACCESSION   XP_005266417
VERSION     XP_005266417.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266360.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..175
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..175
                     /product="G-protein coupled receptor 12 isoform X1"
                     /calculated_mol_wt=19462
     Region          <1..153
                     /region_name="7tm_GPCRs"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; cl28897"
                     /db_xref="CDD:475119"
     Region          1..16
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:410628"
     Region          36..59
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:410628"
     Region          91..113
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:410628"
     Region          121..146
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:410628"
     CDS             1..175
                     /gene="GPR12"
                     /gene_synonym="GPCR12; GPCR21; PPP1R84"
                     /coded_by="XM_005266360.3:297..824"
                     /db_xref="GeneID:2835"
                     /db_xref="HGNC:HGNC:4466"
                     /db_xref="MIM:600752"
ORIGIN      
        1 mlvmlwgtsi clgllpvmgw nclrdestcs vvrpltknna ailsvsflfm falmlqlyiq
       61 ickivmrhah qialqhhfla tshyvttrkg vstlaiilgt faacwmpftl ysliadytyp
      121 siytyatllp atynsiinpv iyafrnqeiq kalcliccgc ipsslaqrar spsdv
//
LOCUS       XP_047286234             204 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 272 isoform X1 [Homo sapiens].
ACCESSION   XP_047286234
VERSION     XP_047286234.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430278.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..204
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..204
                     /product="transmembrane protein 272 isoform X1"
                     /calculated_mol_wt=23276
     CDS             1..204
                     /gene="TMEM272"
                     /gene_synonym="LINC00282; NCRNA00282"
                     /coded_by="XM_047430278.1:50..664"
                     /db_xref="GeneID:283521"
                     /db_xref="HGNC:HGNC:26737"
ORIGIN      
        1 mflrpqftse lcqrartmpg glektchqci skiasnacfv vvlcaflalp lsmtfigmkf
       61 ledcpiqpli plyllvggiv gtlkvsllly dstrmrrlls kavviddddd deypwrqnah
      121 ryyihlllsl flflwfilgn ywvfsvylpd flppfqqpqd ycdktlylfa vgvlalshtv
      181 lvllllcsgc vylcsrwrla aded
//
LOCUS       XP_047286235             187 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 272 isoform X2 [Homo sapiens].
ACCESSION   XP_047286235
VERSION     XP_047286235.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430279.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..187
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..187
                     /product="transmembrane protein 272 isoform X2"
                     /calculated_mol_wt=21209
     CDS             1..187
                     /gene="TMEM272"
                     /gene_synonym="LINC00282; NCRNA00282"
                     /coded_by="XM_047430279.1:89..652"
                     /db_xref="GeneID:283521"
                     /db_xref="HGNC:HGNC:26737"
ORIGIN      
        1 mpgglektch qciskiasna cfvvvlcafl alplsmtfig mkfledcpiq pliplyllvg
       61 givgtlkvsl llydstrmrr llskavvidd ddddeypwrq nahryyihll lslflflwfi
      121 lgnywvfsvy lpdflppfqq pqdycdktly lfavgvlals htvlvllllc sgcvylcsrw
      181 rlaaded
//
LOCUS       XP_047286236             187 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 272 isoform X2 [Homo sapiens].
ACCESSION   XP_047286236
VERSION     XP_047286236.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430280.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..187
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..187
                     /product="transmembrane protein 272 isoform X2"
                     /calculated_mol_wt=21209
     CDS             1..187
                     /gene="TMEM272"
                     /gene_synonym="LINC00282; NCRNA00282"
                     /coded_by="XM_047430280.1:101..664"
                     /db_xref="GeneID:283521"
                     /db_xref="HGNC:HGNC:26737"
ORIGIN      
        1 mpgglektch qciskiasna cfvvvlcafl alplsmtfig mkfledcpiq pliplyllvg
       61 givgtlkvsl llydstrmrr llskavvidd ddddeypwrq nahryyihll lslflflwfi
      121 lgnywvfsvy lpdflppfqq pqdycdktly lfavgvlals htvlvllllc sgcvylcsrw
      181 rlaaded
//
LOCUS       XP_047286237             177 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 272 isoform X3 [Homo sapiens].
ACCESSION   XP_047286237
VERSION     XP_047286237.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430281.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..177
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..177
                     /product="transmembrane protein 272 isoform X3"
                     /calculated_mol_wt=19385
     CDS             1..177
                     /gene="TMEM272"
                     /gene_synonym="LINC00282; NCRNA00282"
                     /coded_by="XM_047430281.1:280..813"
                     /db_xref="GeneID:283521"
                     /db_xref="HGNC:HGNC:26737"
ORIGIN      
        1 mhvhckkkse nrakmkkkmk inhipilkel cqrartmpgg lektchqcis kiasnacfvv
       61 vlcaflalpl smtfigmkfl edcpiqplip lyllvggivg tlkgrqnnfp lsvvaevmgl
      121 apetqifpda ghlpravhic ksflpavefn vlscgfgltr vdaeesltas ytiefsq
//
LOCUS       XP_005266418             463 aa            linear   PRI 05-AUG-2025
DEFINITION  lysosomal proton-coupled steroid conjugate and bile acid symporter
            SLC46A3 isoform X1 [Homo sapiens].
ACCESSION   XP_005266418
VERSION     XP_005266418.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266361.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..463
                     /product="lysosomal proton-coupled steroid conjugate and
                     bile acid symporter SLC46A3 isoform X1"
                     /calculated_mol_wt=51563
     Region          3..437
                     /region_name="MFS_SLC46A3"
                     /note="Solute carrier family 46 member 3 of the Major
                     Facilitator Superfamily of transporters; cd17448"
                     /db_xref="CDD:341006"
     Site            order(13..14,17..18,21,88,142..143,145..147,150,173,
                     176..177,180,267,270..271,274..276,279,308,312,360..361,
                     365,369,385,388..389,392..393,396)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:341006"
     CDS             1..463
                     /gene="SLC46A3"
                     /gene_synonym="FKSG16"
                     /coded_by="XM_005266361.3:254..1645"
                     /db_xref="GeneID:283537"
                     /db_xref="HGNC:HGNC:27501"
                     /db_xref="MIM:616764"
ORIGIN      
        1 mkilfvepai flsafamtlt gplttqyvyr riweetgnyt fssdsnisec eknksspifa
       61 fqeevqkkvs rfnlqmdisg lipglvstfi llsisdhygr kfpmilssvg alatsvwlcl
      121 lcyfafpfql liastfigaf cgnyttfwga cfayivdqck ehkqktiria iidfllglvt
      181 gltglssgyf irelgfewsf liiavslavn liyilfflgd pvkecssqnv tmscsegfkn
      241 lfyrtymlfk nasgkrrfll clllftvity ffvvigiapi filyeldspl cwnevfigyg
      301 salgsasflt sflgiwlfsy cmedihmafi gifttmtgma mtafasttlm mflarvpflf
      361 tivpfsvlrs mlskvvrste qgtlfaciaf letlggvtav stfngiysat vawypgftfl
      421 lsagllllpa islcvvkcts wnegsyelli qeessedasd rac
//
LOCUS       XP_047286238             100 aa            linear   PRI 05-AUG-2025
DEFINITION  regulator of cell cycle RGCC isoform X1 [Homo sapiens].
ACCESSION   XP_047286238
VERSION     XP_047286238.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430282.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..100
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..100
                     /product="regulator of cell cycle RGCC isoform X1"
                     /calculated_mol_wt=10375
     Region          26..>78
                     /region_name="RGCC"
                     /note="Response gene to complement 32 protein family;
                     pfam15151"
                     /db_xref="CDD:464535"
     CDS             1..100
                     /gene="RGCC"
                     /gene_synonym="bA157L14.2; C13orf15; RGC-32; RGC32"
                     /coded_by="XM_047430282.1:159..461"
                     /db_xref="GeneID:28984"
                     /db_xref="HGNC:HGNC:20369"
                     /db_xref="MIM:610077"
ORIGIN      
        1 mkppaaqgsp aaaaaaapal dsaaaedlsd alcefdavla dfaspfherh fhyeehlerm
       61 krrssasvsd ssgfsdseif talsegaptl qgrsnskpvl
//
LOCUS       XP_011533354             275 aa            linear   PRI 05-AUG-2025
DEFINITION  general transcription factor IIF subunit 2 isoform X1 [Homo
            sapiens].
ACCESSION   XP_011533354
VERSION     XP_011533354.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535052.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..275
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..275
                     /product="general transcription factor IIF subunit 2
                     isoform X1"
                     /calculated_mol_wt=30785
     Region          5..144
                     /region_name="TFIIF_beta"
                     /note="Transcription initiation factor IIF, beta subunit;
                     cd07980"
                     /db_xref="CDD:259828"
     Site            order(5,11,13,18..25,28,31,34,39..47,53,90..100,130,
                     132..133,139)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:259828"
     Region          202..266
                     /region_name="TFIIF_beta"
                     /note="TFIIF, beta subunit HTH domain; pfam02270"
                     /db_xref="CDD:426691"
     CDS             1..275
                     /gene="GTF2F2"
                     /gene_synonym="BTF4; RAP30; TF2F2; TFIIF"
                     /coded_by="XM_011535052.4:147..974"
                     /db_xref="GeneID:2963"
                     /db_xref="HGNC:HGNC:4653"
                     /db_xref="MIM:189969"
ORIGIN      
        1 maergeldlt gakqntgvwl vkvpkylsqq wakasgrgev gklriaktqg rtevsftlne
       61 dlanihdigg kpasvsapre hpfvlqsvgg qtltvftess sggsrmtagv ttvistsqas
      121 kgkqdgedkl slegivvqra ecrpaaseny mrlkrlqiee sskpvrlsqq ldkvvttnyk
      181 pvanhqynie yerkkkedgk raradkqhvl dmlfsafekh qyynlkdlvd itkqpvvylk
      241 eilkeigvqn vkgihkntwe lkpeyrhyqg eeksd
//
LOCUS       XP_016876040             149 aa            linear   PRI 05-AUG-2025
DEFINITION  general transcription factor IIF subunit 2 isoform X2 [Homo
            sapiens].
ACCESSION   XP_016876040
VERSION     XP_016876040.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020551.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..149
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..149
                     /product="general transcription factor IIF subunit 2
                     isoform X2"
                     /calculated_mol_wt=17532
     Region          76..140
                     /region_name="TFIIF_beta"
                     /note="TFIIF, beta subunit HTH domain; pfam02270"
                     /db_xref="CDD:426691"
     CDS             1..149
                     /gene="GTF2F2"
                     /gene_synonym="BTF4; RAP30; TF2F2; TFIIF"
                     /coded_by="XM_017020551.2:156..605"
                     /db_xref="GeneID:2963"
                     /db_xref="HGNC:HGNC:4653"
                     /db_xref="MIM:189969"
ORIGIN      
        1 mdklslegiv vqraecrpaa senymrlkrl qieesskpvr lsqqldkvvt tnykpvanhq
       61 ynieyerkkk edgkraradk qhvldmlfsa fekhqyynlk dlvditkqpv vylkeilkei
      121 gvqnvkgihk ntwelkpeyr hyqgeeksd
//
LOCUS       XP_011533355             131 aa            linear   PRI 05-AUG-2025
DEFINITION  general transcription factor IIF subunit 2 isoform X3 [Homo
            sapiens].
ACCESSION   XP_011533355
VERSION     XP_011533355.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535053.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..131
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..131
                     /product="general transcription factor IIF subunit 2
                     isoform X3"
                     /calculated_mol_wt=13614
     Region          5..>103
                     /region_name="TFIIF_beta"
                     /note="Transcription initiation factor IIF, beta subunit;
                     cd07980"
                     /db_xref="CDD:259828"
     Site            order(5,11,13,18..25,28,31,34,39..47,53,90..100)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:259828"
     CDS             1..131
                     /gene="GTF2F2"
                     /gene_synonym="BTF4; RAP30; TF2F2; TFIIF"
                     /coded_by="XM_011535053.4:147..542"
                     /db_xref="GeneID:2963"
                     /db_xref="HGNC:HGNC:4653"
                     /db_xref="MIM:189969"
ORIGIN      
        1 maergeldlt gakqntgvwl vkvpkylsqq wakasgrgev gklriaktqg rtevsftlne
       61 dlanihdigg kpasvsapre hpfvlqsvgg qtltvftess sggsrmtagv ttvistsqas
      121 kgkqdgegqs a
//
LOCUS       XP_047286239             261 aa            linear   PRI 05-AUG-2025
DEFINITION  dolichyl-phosphate beta-glucosyltransferase isoform X1 [Homo
            sapiens].
ACCESSION   XP_047286239
VERSION     XP_047286239.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430283.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..261
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..261
                     /product="dolichyl-phosphate beta-glucosyltransferase
                     isoform X1"
                     /calculated_mol_wt=29968
     Region          36..226
                     /region_name="DPG_synthase"
                     /note="DPG_synthase is involved in protein N-linked
                     glycosylation; cd04188"
                     /db_xref="CDD:133031"
     Site            order(47,101..102)
                     /site_type="active"
                     /note="Putative Catalytic site [active]"
                     /db_xref="CDD:133031"
     Site            100..102
                     /site_type="active"
                     /note="DXD motif [active]"
                     /db_xref="CDD:133031"
     CDS             1..261
                     /gene="ALG5"
                     /gene_synonym="bA421P11.2; PKD7"
                     /coded_by="XM_047430283.1:78..863"
                     /db_xref="GeneID:29880"
                     /db_xref="HGNC:HGNC:20266"
                     /db_xref="MIM:604565"
ORIGIN      
        1 mpkarkklyp aygthlpnnf lslclhtmkk ngkrdpafty evivvddgsk dqtskvafky
       61 cqkygsdkvr vitlvknrgk ggairmgifs srgekilmad adgatkfpdv eklekglndl
      121 qpwpnqmaia cgsrahleke siaqrsyfrt llmygfhflv wflcvkgird tqcgfklftr
      181 eaasrtfssl hverwafdve llyiaqffki piaeiavnwt eiegsklvpf wswlqmgkdl
      241 lfirlryltg awrleqtrkm n
//
LOCUS       XP_047286240             174 aa            linear   PRI 05-AUG-2025
DEFINITION  high mobility group protein B1 isoform X3 [Homo sapiens].
ACCESSION   XP_047286240
VERSION     XP_047286240.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430284.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..174
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..174
                     /product="high mobility group protein B1 isoform X3"
                     /calculated_mol_wt=19806
     Region          8..76
                     /region_name="HMG-box_HMGB_rpt1"
                     /note="first high mobility group (HMG)-box found in the
                     high mobility group protein B (HMGB) family; cd21978"
                     /db_xref="CDD:438794"
     Site            order(8..10,13,16..17,19..21,25,28,35..36,38..39,41..43,
                     45..46,50)
                     /site_type="other"
                     /note="p53 binding site [polypeptide binding]"
                     /db_xref="CDD:438794"
     Site            order(8,10..11,13..17,20..21,36,38..39,41..43,46,49)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:438794"
     Region          93..157
                     /region_name="HMG-box_HMGB_rpt2"
                     /note="second high mobility group (HMG)-box found in the
                     high mobility group protein B (HMGB) family; cd21979"
                     /db_xref="CDD:438795"
     Site            order(94..100,102..104,106..107,110,122..123,125..127,130,
                     133,152,155..156)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:438795"
     CDS             1..174
                     /gene="HMGB1"
                     /gene_synonym="HMG-1; HMG1; HMG3; SBP-1"
                     /coded_by="XM_047430284.1:156..680"
                     /db_xref="GeneID:3146"
                     /db_xref="HGNC:HGNC:4983"
                     /db_xref="MIM:163905"
ORIGIN      
        1 mgkgdpkkpr gkmssyaffv qtcreehkkk hpdasvnfse fskkcserwk tmsakekgkf
       61 edmakadkar yeremktyip pkgetkkkfk dpnapkrpps afflfcseyr pkikgehpgl
      121 sigdvakklg emwnntaadd kqpyekkaak lkekyekvrs vgllgkmmts tpdv
//
LOCUS       XP_047286241             158 aa            linear   PRI 05-AUG-2025
DEFINITION  high mobility group protein B1 isoform X2 [Homo sapiens].
ACCESSION   XP_047286241
VERSION     XP_047286241.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430285.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..158
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..158
                     /product="high mobility group protein B1 isoform X2"
                     /calculated_mol_wt=18180
     Region          8..76
                     /region_name="HMG-box_HMGB_rpt1"
                     /note="first high mobility group (HMG)-box found in the
                     high mobility group protein B (HMGB) family; cd21978"
                     /db_xref="CDD:438794"
     Site            order(8..10,13,16..17,19..21,25,28,35..36,38..39,41..43,
                     45..46,50)
                     /site_type="other"
                     /note="p53 binding site [polypeptide binding]"
                     /db_xref="CDD:438794"
     Site            order(8,10..11,13..17,20..21,36,38..39,41..43,46,49)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:438794"
     Region          93..157
                     /region_name="HMG-box_HMGB_rpt2"
                     /note="second high mobility group (HMG)-box found in the
                     high mobility group protein B (HMGB) family; cd21979"
                     /db_xref="CDD:438795"
     Site            order(94..100,102..104,106..107,110,122..123,125..127,130,
                     133,152,155..156)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:438795"
     CDS             1..158
                     /gene="HMGB1"
                     /gene_synonym="HMG-1; HMG1; HMG3; SBP-1"
                     /coded_by="XM_047430285.1:738..1214"
                     /db_xref="GeneID:3146"
                     /db_xref="HGNC:HGNC:4983"
                     /db_xref="MIM:163905"
ORIGIN      
        1 mgkgdpkkpr gkmssyaffv qtcreehkkk hpdasvnfse fskkcserwk tmsakekgkf
       61 edmakadkar yeremktyip pkgetkkkfk dpnapkrpps afflfcseyr pkikgehpgl
      121 sigdvakklg emwnntaadd kqpyekkaak lkekyekf
//
LOCUS       XP_011519384             225 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin-associated domain-containing protein 2 isoform X1 [Homo
            sapiens].
ACCESSION   XP_011519384
VERSION     XP_011519384.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521082.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XP_011519384.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..225
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..225
                     /product="ubiquitin-associated domain-containing protein 2
                     isoform X1"
                     /calculated_mol_wt=25361
     Region          186..223
                     /region_name="UBA_UBAC2"
                     /note="UBA domain found in ubiquitin-associated
                     domain-containing protein 2 (UBAC2) and similar proteins;
                     cd14305"
                     /db_xref="CDD:270490"
     CDS             1..225
                     /gene="UBAC2"
                     /gene_synonym="PHGDHL1"
                     /coded_by="XM_011521082.3:183..860"
                     /db_xref="GeneID:337867"
                     /db_xref="HGNC:HGNC:20486"
ORIGIN      
        1 mtftqsrtts slapvfalfv pfycsiprvq vaqilgplsi tnktliyilg lqlftsgsyi
       61 wivaisglms glcydskmfq vhqvlcipsw makffswtle pifsssepts earigmgatl
      121 diqrqqrmel ldrqlmfsqf aqgrrqrqqq ggminwnrlf pplrqrqnvn yqggrqsepa
      181 applevseeq varlmemgfs rgdalealra snndlnvatn fllqh
//
LOCUS       XP_011519385             292 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin-associated domain-containing protein 2 isoform X2 [Homo
            sapiens].
ACCESSION   XP_011519385
VERSION     XP_011519385.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521083.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..292
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..292
                     /product="ubiquitin-associated domain-containing protein 2
                     isoform X2"
                     /calculated_mol_wt=32628
     Region          253..290
                     /region_name="UBA_UBAC2"
                     /note="UBA domain found in ubiquitin-associated
                     domain-containing protein 2 (UBAC2) and similar proteins;
                     cd14305"
                     /db_xref="CDD:270490"
     CDS             1..292
                     /gene="UBAC2"
                     /gene_synonym="PHGDHL1"
                     /coded_by="XM_011521083.3:121..999"
                     /db_xref="GeneID:337867"
                     /db_xref="HGNC:HGNC:20486"
ORIGIN      
        1 mrvlssggkl gsrgegaqlc cwmllfswrv sggqqtrrlc rrafcwspvp spscspsscl
       61 tarsslcmtf tqsrttssla pvfalfvpfy csiprvqvaq ilgplsitnk tliyilglql
      121 ftsgsyiwiv aisglmsglc ydskmfqvhq vlcipswmak ffswtlepif ssseptsear
      181 igmgatldiq rqqrmelldr qlmfsqfaqg rrqrqqqggm inwnrlfppl rqrqnvnyqg
      241 grqsepaapp levseeqvar lmemgfsrgd alealrasnn dlnvatnfll qh
//
LOCUS       XP_047286242             231 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin-associated domain-containing protein 2 isoform X3 [Homo
            sapiens].
ACCESSION   XP_047286242
VERSION     XP_047286242.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430286.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..231
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..231
                     /product="ubiquitin-associated domain-containing protein 2
                     isoform X3"
                     /calculated_mol_wt=25966
     Region          192..229
                     /region_name="UBA_UBAC2"
                     /note="UBA domain found in ubiquitin-associated
                     domain-containing protein 2 (UBAC2) and similar proteins;
                     cd14305"
                     /db_xref="CDD:270490"
     CDS             1..231
                     /gene="UBAC2"
                     /gene_synonym="PHGDHL1"
                     /coded_by="XM_047430286.1:389..1084"
                     /db_xref="GeneID:337867"
                     /db_xref="HGNC:HGNC:20486"
ORIGIN      
        1 mqyffgitaa snlpsgflap vfalfvpfyc siprvqvaqi lgplsitnkt liyilglqlf
       61 tsgsyiwiva isglmsglcy dskmfqvhqv lcipswmakf fswtlepifs sseptseari
      121 gmgatldiqr qqrmelldrq lmfsqfaqgr rqrqqqggmi nwnrlfpplr qrqnvnyqgg
      181 rqsepaappl evseeqvarl memgfsrgda lealrasnnd lnvatnfllq h
//
LOCUS       XP_016876042             174 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin-associated domain-containing protein 2 isoform X4 [Homo
            sapiens].
ACCESSION   XP_016876042
VERSION     XP_016876042.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020553.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..174
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..174
                     /product="ubiquitin-associated domain-containing protein 2
                     isoform X4"
                     /calculated_mol_wt=19863
     Region          135..172
                     /region_name="UBA_UBAC2"
                     /note="UBA domain found in ubiquitin-associated
                     domain-containing protein 2 (UBAC2) and similar proteins;
                     cd14305"
                     /db_xref="CDD:270490"
     CDS             1..174
                     /gene="UBAC2"
                     /gene_synonym="PHGDHL1"
                     /coded_by="XM_017020553.2:7846..8370"
                     /db_xref="GeneID:337867"
                     /db_xref="HGNC:HGNC:20486"
ORIGIN      
        1 msvltpiphc tddysfmmsg lcydskmfqv hqvlcipswm akffswtlep ifssseptse
       61 arigmgatld iqrqqrmell drqlmfsqfa qgrrqrqqqg gminwnrlfp plrqrqnvny
      121 qggrqsepaa pplevseeqv arlmemgfsr gdalealras nndlnvatnf llqh
//
LOCUS       XP_016876043            1764 aa            linear   PRI 05-AUG-2025
DEFINITION  FRAS1-related extracellular matrix protein 2 isoform X1 [Homo
            sapiens].
ACCESSION   XP_016876043
VERSION     XP_016876043.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020554.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1764
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1764
                     /product="FRAS1-related extracellular matrix protein 2
                     isoform X1"
                     /calculated_mol_wt=194975
     Region          72..284
                     /region_name="Frem_N"
                     /note="Frem protein N-terminal domain; pfam19309"
                     /db_xref="CDD:466034"
     Region          <336..396
                     /region_name="Cadherin_3"
                     /note="Cadherin-like; pfam16184"
                     /db_xref="CDD:465048"
     Region          422..539
                     /region_name="Cadherin_3"
                     /note="Cadherin-like; pfam16184"
                     /db_xref="CDD:465048"
     Region          543..676
                     /region_name="Cadherin_3"
                     /note="Cadherin-like; pfam16184"
                     /db_xref="CDD:465048"
     Region          683..808
                     /region_name="Cadherin_3"
                     /note="Cadherin-like; pfam16184"
                     /db_xref="CDD:465048"
     Region          815..920
                     /region_name="Cadherin_3"
                     /note="Cadherin-like; pfam16184"
                     /db_xref="CDD:465048"
     Region          923..1038
                     /region_name="Cadherin_3"
                     /note="Cadherin-like; pfam16184"
                     /db_xref="CDD:465048"
     Region          1053..1170
                     /region_name="Cadherin_3"
                     /note="Cadherin-like; pfam16184"
                     /db_xref="CDD:465048"
     Region          1174..1284
                     /region_name="Cadherin_3"
                     /note="Cadherin-like; pfam16184"
                     /db_xref="CDD:465048"
     Region          1286..1401
                     /region_name="Cadherin_3"
                     /note="Cadherin-like; pfam16184"
                     /db_xref="CDD:465048"
     Region          1406..1514
                     /region_name="Cadherin_3"
                     /note="Cadherin-like; pfam16184"
                     /db_xref="CDD:465048"
     Region          1516..1623
                     /region_name="Cadherin_3"
                     /note="Cadherin-like; pfam16184"
                     /db_xref="CDD:465048"
     Region          1641..1754
                     /region_name="Cadherin_3"
                     /note="Cadherin-like; pfam16184"
                     /db_xref="CDD:465048"
     CDS             1..1764
                     /gene="FREM2"
                     /gene_synonym="CRYPTOP; FRASRS2"
                     /coded_by="XM_017020554.2:269..5563"
                     /db_xref="GeneID:341640"
                     /db_xref="HGNC:HGNC:25396"
                     /db_xref="MIM:608945"
ORIGIN      
        1 mhsagtpgls srrtgnstsf qpgppppprl llllllllsl vsrvpaqpaa fgrallspgl
       61 agaagvpaee aivlanrglr vpfgrevwld plhdlvlqvq pgdrcavsvl dndalaqrpg
      121 rlspkrfpcd fgpgevrysh lgarspsrdr vrlqlrydap ggavvlplvl evevvftqle
      181 vvtrnlplvv eellgtsnal darslefafq peteecrvgi lsglgalpry gellhypqvp
      241 ggareggape tllmdckafq elgvryrhta asrspnrdwi pmvvelrsrg apvgspalkr
      301 ehfqvlvrir ggaentapkp sfvammmmev dqfvltaltp dmlaaedaes psdllifnlt
      361 spfqpgqgyl vstddrslpl ssftqrdlrl lkiayqppse dsdqerlfel elevvdlega
      421 asdpfafmvv vkpmntmapv vtrntglily egqsrpltgp agsgpqnlvi sdeddleavr
      481 levvaglrhg hlvilgassg ssapksftva elaagqvvyq hddrdgslsd nlvlrmvdgg
      541 grhqvqflfp itlvpvddqp pvlnantglt laegetvpil plslsatdmd sddslllfvl
      601 espflttghl llrqthpphe kqellrglwr kegafyertv tewqqqdite grlfyrhsgp
      661 hspgpvtdqf tfrvqdnhdp pnqsglqrfv irihpvdrlp pelgsgcplr mvvqesqltp
      721 lrkkwlrytd ldtddrelry tvtqpptdtd enhlpaplgt lvltdnpsvv vthftqaqin
      781 hhkiayrppg qelgvatrva qfqfqvedra gnvapgtftl ylhpvdnqpp eilntgftiq
      841 ekghhilset elhvndvdtd vahisftltq apkhghmrvs gqilhvgglf hledikqgrv
      901 syahngdksl tdscslevsd rhhvvpitlr vnvrpvddev pilshptgtl esyldvleng
      961 ateitanvik gtneetddlm ltflledppl ygeilvngip aeqftqrdil egsvvythts
     1021 geigllpkad sfnlslsdms qewriggnti qgvtiwvtil pvdsqapeif vgeqlivmeg
     1081 dksvitsvhi saedvdslnd dilctiviqp tsgyvenisp apgseksrag iaisafnlkd
     1141 lrqghinyvq svhkgvepve drfvfrcsdg infserqffp iviiptndeq pemfmrefmv
     1201 megmslvidt pilnaadadv plddltftit qfpthghimn qlingtvlve sftldqiies
     1261 ssiiyehdds etqedsfvik ltdgkhsvek tvliivipvd detprmtinn gleieigdtk
     1321 iinnkilmat dldsedkslv yiirygpghg llqrrkptga fenitlgmnf tqdevdrnli
     1381 qyvhlgqegi rdlikfdvtd ginplidryf yvsigsidiv fpdviskgvs lkeggkvtlt
     1441 tdllstsdln spdenlvfti trapmrghle ctdqpgvsit sftqlqlagn kiyyihtadd
     1501 evkmdsfefq vtdgrnpvfr tfrisisdvd nkkpvvtihk lvvsesenkl itpfeltved
     1561 rdtpdkllkf titqvpihgh llfnntrpvm vftkqdlnen lisykhdgte ssedsfsftv
     1621 tdgthtdfyv fpdtvfetrr pqvmkiqvla vdnsvpqiav nkgastlrtl atghlgfmit
     1681 skilkvedrd slhislrfiv teapqhgyll nldkgnhsit qftqadiddm kicyvlrega
     1741 natsdmfyfa vedgakipqk erqd
//
LOCUS       XP_047286243             904 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase Nek5 isoform X1 [Homo sapiens].
ACCESSION   XP_047286243
VERSION     XP_047286243.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430287.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..904
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..904
                     /product="serine/threonine-protein kinase Nek5 isoform X1"
                     /calculated_mol_wt=102978
     Region          75..331
                     /region_name="STKc_Nek5"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     Never In Mitosis gene A (NIMA)-related kinase 5; cd08225"
                     /db_xref="CDD:173765"
     Site            order(82..86,90,103,105,136,152..155,159,161,200,202,
                     204..205,207,219,222,224,238..241)
                     /site_type="active"
                     /db_xref="CDD:173765"
     Site            order(82..83,85..86,90,103,105,136,153..155,159,205,207,
                     224)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:173765"
     Site            order(86,159,161,200,202,204,222,238..241)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:173765"
     Site            218..241
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:173765"
     CDS             1..904
                     /gene="NEK5"
                     /coded_by="XM_047430287.1:126..2840"
                     /db_xref="GeneID:341676"
                     /db_xref="HGNC:HGNC:7748"
                     /db_xref="MIM:616731"
ORIGIN      
        1 mefrpgaaga aqkrpsvlgc vgvasrarrs lwqrstrggr vrlsvatkkv iclclgkagr
       61 kvlakklspl etmdkydvik aigqgafgka ylakgksdsk hcvikeinfe kmpiqekeas
      121 kkevillekm khpnivaffn sfqengrlfi vmeycdggdl mkrinrqrgv lfsedqilgw
      181 fvqislglkh ihdrkilhrd ikaqniflsk ngmvaklgdf giarvlnnsm elartcigtp
      241 yylspeicqn kpynnktdiw slgcvlyelc tlkhpfegnn lqqlvlkicq ahfapispgf
      301 srelhslisq lfqvsprdrp sinsilkrpf lenlipkylt peviqeefsh mlicragapa
      361 srhagkvvqk ckiqkvrfqg kcpprsrisv pikrnailhr newrppagaq karsikmier
      421 pkiaavcghy dyyyaqldml rrrahkpsyh pipqentgve dygqetrhgp spsqwpaeyl
      481 qrkfeaqqyk lkvekqlglr pssaepnynq rqelrsngee prfqelpfrk nemkeqeywk
      541 qleeirqqyh ndmkeirkkm grepeenski shktylvkks nlpvhqdase geapvqdiek
      601 dlkqmrlqnt kesknpeqky kakkgvkfei nldkcisden ilqeeeamdi pnetltfedg
      661 mkfkeyecvk ehgdytdkaf eklhcpeagf stqtvaavgn rrqwdggapq tllqmmavad
      721 itstcptgpd ngqviviegi pgnrkqwrhe apgtlmsvla aahltsssfs adeefamgtl
      781 kqwlpkeede gkvemvsgie vdeeqleprs ddddtnfees edelrdevve yleklatfkg
      841 eekteeasst skdsrksrer egismqksee lreglenist tsndhicitd edqgtsttsq
      901 niqv
//
LOCUS       XP_047286244             903 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase Nek5 isoform X2 [Homo sapiens].
ACCESSION   XP_047286244
VERSION     XP_047286244.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430288.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..903
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..903
                     /product="serine/threonine-protein kinase Nek5 isoform X2"
                     /calculated_mol_wt=102850
     Region          75..331
                     /region_name="STKc_Nek5"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     Never In Mitosis gene A (NIMA)-related kinase 5; cd08225"
                     /db_xref="CDD:173765"
     Site            order(82..86,90,103,105,136,152..155,159,161,200,202,
                     204..205,207,219,222,224,238..241)
                     /site_type="active"
                     /db_xref="CDD:173765"
     Site            order(82..83,85..86,90,103,105,136,153..155,159,205,207,
                     224)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:173765"
     Site            order(86,159,161,200,202,204,222,238..241)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:173765"
     Site            218..241
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:173765"
     CDS             1..903
                     /gene="NEK5"
                     /coded_by="XM_047430288.1:126..2837"
                     /db_xref="GeneID:341676"
                     /db_xref="HGNC:HGNC:7748"
                     /db_xref="MIM:616731"
ORIGIN      
        1 mefrpgaaga aqkrpsvlgc vgvasrarrs lwqrstrggr vrlsvatkkv iclclgkagr
       61 kvlakklspl etmdkydvik aigqgafgka ylakgksdsk hcvikeinfe kmpiqekeas
      121 kkevillekm khpnivaffn sfqengrlfi vmeycdggdl mkrinrqrgv lfsedqilgw
      181 fvqislglkh ihdrkilhrd ikaqniflsk ngmvaklgdf giarvlnnsm elartcigtp
      241 yylspeicqn kpynnktdiw slgcvlyelc tlkhpfegnn lqqlvlkicq ahfapispgf
      301 srelhslisq lfqvsprdrp sinsilkrpf lenlipkylt peviqeefsh mlicragapa
      361 srhagkvvqk ckiqkvrfqg kcpprsrisv pikrnailhr newrppagaq karsikmier
      421 pkiaavcghy dyyyaqldml rrrahkpsyh pipqentgve dygqetrhgp spsqwpaeyl
      481 qrkfeaqqyk lkvekqlglr pssaepnynq rqelrsngee prfqelpfrk nemkeqeywk
      541 qleeirqqyh ndmkeirkkm grepeenski shktylvkks nlpvhqdase geapvqdiek
      601 dlkqmrlqnt kesknpeqky kakgvkfein ldkcisdeni lqeeeamdip netltfedgm
      661 kfkeyecvke hgdytdkafe klhcpeagfs tqtvaavgnr rqwdggapqt llqmmavadi
      721 tstcptgpdn gqviviegip gnrkqwrhea pgtlmsvlaa ahltsssfsa deefamgtlk
      781 qwlpkeedeg kvemvsgiev deeqleprsd dddtnfeese delrdevvey leklatfkge
      841 ekteeassts kdsrksrere gismqkseel reglenistt sndhicitde dqgtsttsqn
      901 iqv
//
LOCUS       XP_047286245             889 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase Nek5 isoform X3 [Homo sapiens].
ACCESSION   XP_047286245
VERSION     XP_047286245.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430289.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..889
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..889
                     /product="serine/threonine-protein kinase Nek5 isoform X3"
                     /calculated_mol_wt=101320
     Region          60..316
                     /region_name="STKc_Nek5"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     Never In Mitosis gene A (NIMA)-related kinase 5; cd08225"
                     /db_xref="CDD:173765"
     Site            order(67..71,75,88,90,121,137..140,144,146,185,187,
                     189..190,192,204,207,209,223..226)
                     /site_type="active"
                     /db_xref="CDD:173765"
     Site            order(67..68,70..71,75,88,90,121,138..140,144,190,192,209)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:173765"
     Site            order(71,144,146,185,187,189,207,223..226)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:173765"
     Site            203..226
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:173765"
     CDS             1..889
                     /gene="NEK5"
                     /coded_by="XM_047430289.1:458..3127"
                     /db_xref="GeneID:341676"
                     /db_xref="HGNC:HGNC:7748"
                     /db_xref="MIM:616731"
ORIGIN      
        1 mqivgspgpg aawpvkrvvf pngeqfllsv atkkviclcl gkagrkvlak klspletmdk
       61 ydvikaigqg afgkaylakg ksdskhcvik einfekmpiq ekeaskkevi llekmkhpni
      121 vaffnsfqen grlfivmeyc dggdlmkrin rqrgvlfsed qilgwfvqis lglkhihdrk
      181 ilhrdikaqn iflskngmva klgdfgiarv lnnsmelart cigtpyylsp eicqnkpynn
      241 ktdiwslgcv lyelctlkhp fegnnlqqlv lkicqahfap ispgfsrelh slisqlfqvs
      301 prdrpsinsi lkrpflenli pkyltpeviq eefshmlicr agapasrhag kvvqkckiqk
      361 vrfqgkcppr srisvpikrn ailhrnewrp pagaqkarsi kmierpkiaa vcghydyyya
      421 qldmlrrrah kpsyhpipqe ntgvedygqe trhgpspsqw paeylqrkfe aqqyklkvek
      481 qlglrpssae pnynqrqelr sngeeprfqe lpfrknemke qeywkqleei rqqyhndmke
      541 irkkmgrepe enskishkty lvkksnlpvh qdasegeapv qdiekdlkqm rlqntkeskn
      601 peqkykakkg vkfeinldkc isdenilqee eamdipnetl tfedgmkfke yecvkehgdy
      661 tdkafeklhc peagfstqtv aavgnrrqwd ggapqtllqm mavaditstc ptgpdngqvi
      721 viegipgnrk qwrheapgtl msvlaaahlt sssfsadeef amgtlkqwlp keedegkvem
      781 vsgievdeeq leprsddddt nfeesedelr devveylekl atfkgeekte easstskdsr
      841 ksreregism qkseelregl enisttsndh icitdedqgt sttsqniqv
//
LOCUS       XP_047286246             881 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase Nek5 isoform X4 [Homo sapiens].
ACCESSION   XP_047286246
VERSION     XP_047286246.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430290.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..881
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..881
                     /product="serine/threonine-protein kinase Nek5 isoform X4"
                     /calculated_mol_wt=100302
     Region          75..331
                     /region_name="STKc_Nek5"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     Never In Mitosis gene A (NIMA)-related kinase 5; cd08225"
                     /db_xref="CDD:173765"
     Site            order(82..86,90,103,105,136,152..155,159,161,200,202,
                     204..205,207,219,222,224,238..241)
                     /site_type="active"
                     /db_xref="CDD:173765"
     Site            order(82..83,85..86,90,103,105,136,153..155,159,205,207,
                     224)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:173765"
     Site            order(86,159,161,200,202,204,222,238..241)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:173765"
     Site            218..241
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:173765"
     CDS             1..881
                     /gene="NEK5"
                     /coded_by="XM_047430290.1:126..2771"
                     /db_xref="GeneID:341676"
                     /db_xref="HGNC:HGNC:7748"
                     /db_xref="MIM:616731"
ORIGIN      
        1 mefrpgaaga aqkrpsvlgc vgvasrarrs lwqrstrggr vrlsvatkkv iclclgkagr
       61 kvlakklspl etmdkydvik aigqgafgka ylakgksdsk hcvikeinfe kmpiqekeas
      121 kkevillekm khpnivaffn sfqengrlfi vmeycdggdl mkrinrqrgv lfsedqilgw
      181 fvqislglkh ihdrkilhrd ikaqniflsk ngmvaklgdf giarvlnnsm elartcigtp
      241 yylspeicqn kpynnktdiw slgcvlyelc tlkhpfegnn lqqlvlkicq ahfapispgf
      301 srelhslisq lfqvsprdrp sinsilkrpf lenlipkylt peviqeefsh mlicragapa
      361 srhagkvvqk ckiqkvrfqg kcpprsrisv pikrnailhr newrppagaq karsikmier
      421 pkiaavcghy dyyyaqldml rrrahkpsyh pipqentgve dygqetrhgp spsqwpaeyl
      481 qrkfeaqqyk lkvekqlglr pssaepnynq rqelrsngee prfqelpfrk nemkeqeywk
      541 qleeirqqyh ndmkeirkkm grepeenski shktylvkks nlpvhqdase geapvqdiek
      601 dlkqmrlqnt kesknpeqky kakamdipne tltfedgmkf keyecvkehg dytdkafekl
      661 hcpeagfstq tvaavgnrrq wdggapqtll qmmavadits tcptgpdngq viviegipgn
      721 rkqwrheapg tlmsvlaaah ltsssfsade efamgtlkqw lpkeedegkv emvsgievde
      781 eqleprsddd dtnfeesede lrdevveyle klatfkgeek teeasstskd srksreregi
      841 smqkseelre glenisttsn dhicitdedq gtsttsqniq v
//
LOCUS       XP_047286247             873 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase Nek5 isoform X5 [Homo sapiens].
ACCESSION   XP_047286247
VERSION     XP_047286247.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430291.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..873
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..873
                     /product="serine/threonine-protein kinase Nek5 isoform X5"
                     /calculated_mol_wt=99561
     Region          75..331
                     /region_name="STKc_Nek5"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     Never In Mitosis gene A (NIMA)-related kinase 5; cd08225"
                     /db_xref="CDD:173765"
     Site            order(82..86,90,103,105,136,152..155,159,161,200,202,
                     204..205,207,219,222,224,238..241)
                     /site_type="active"
                     /db_xref="CDD:173765"
     Site            order(82..83,85..86,90,103,105,136,153..155,159,205,207,
                     224)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:173765"
     Site            order(86,159,161,200,202,204,222,238..241)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:173765"
     Site            218..241
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:173765"
     CDS             1..873
                     /gene="NEK5"
                     /coded_by="XM_047430291.1:126..2747"
                     /db_xref="GeneID:341676"
                     /db_xref="HGNC:HGNC:7748"
                     /db_xref="MIM:616731"
ORIGIN      
        1 mefrpgaaga aqkrpsvlgc vgvasrarrs lwqrstrggr vrlsvatkkv iclclgkagr
       61 kvlakklspl etmdkydvik aigqgafgka ylakgksdsk hcvikeinfe kmpiqekeas
      121 kkevillekm khpnivaffn sfqengrlfi vmeycdggdl mkrinrqrgv lfsedqilgw
      181 fvqislglkh ihdrkilhrd ikaqniflsk ngmvaklgdf giarvlnnsm elartcigtp
      241 yylspeicqn kpynnktdiw slgcvlyelc tlkhpfegnn lqqlvlkicq ahfapispgf
      301 srelhslisq lfqvsprdrp sinsilkrpf lenlipkylt peviqeefsh mlicragapa
      361 srhagkvvqk ckiqkvrfqg kcpprsrisv pikrnailhr newrppagaq karsikmier
      421 pkiaavcghy dyyyaqldml rrrahkpsyh pipqentgve dygqetrhgp spsqwpaeyl
      481 qrkfeaqqyk lkvekqlglr pssaepnynq rqelrsngee prfqelpfrk nemkeqeywk
      541 qleeirqqyh ndmkeirkkm grepediekd lkqmrlqntk esknpeqkyk akkgvkfein
      601 ldkcisdeni lqeeeamdip netltfedgm kfkeyecvke hgdytdkafe klhcpeagfs
      661 tqtvaavgnr rqwdggapqt llqmmavadi tstcptgpdn gqviviegip gnrkqwrhea
      721 pgtlmsvlaa ahltsssfsa deefamgtlk qwlpkeedeg kvemvsgiev deeqleprsd
      781 dddtnfeese delrdevvey leklatfkge ekteeassts kdsrksrere gismqkseel
      841 reglenistt sndhicitde dqgtsttsqn iqv
//
LOCUS       XP_047286248             832 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase Nek5 isoform X6 [Homo sapiens].
ACCESSION   XP_047286248
VERSION     XP_047286248.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430292.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..832
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..832
                     /product="serine/threonine-protein kinase Nek5 isoform X6"
                     /calculated_mol_wt=95305
     Region          3..259
                     /region_name="STKc_Nek5"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     Never In Mitosis gene A (NIMA)-related kinase 5; cd08225"
                     /db_xref="CDD:173765"
     Site            order(10..14,18,31,33,64,80..83,87,89,128,130,132..133,
                     135,147,150,152,166..169)
                     /site_type="active"
                     /db_xref="CDD:173765"
     Site            order(10..11,13..14,18,31,33,64,81..83,87,133,135,152)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:173765"
     Site            order(14,87,89,128,130,132,150,166..169)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:173765"
     Site            146..169
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:173765"
     CDS             1..832
                     /gene="NEK5"
                     /coded_by="XM_047430292.1:68..2566"
                     /db_xref="GeneID:341676"
                     /db_xref="HGNC:HGNC:7748"
                     /db_xref="MIM:616731"
ORIGIN      
        1 mdkydvikai gqgafgkayl akgksdskhc vikeinfekm piqekeaskk evillekmkh
       61 pnivaffnsf qengrlfivm eycdggdlmk rinrqrgvlf sedqilgwfv qislglkhih
      121 drkilhrdik aqniflskng mvaklgdfgi arvlnnsmel artcigtpyy lspeicqnkp
      181 ynnktdiwsl gcvlyelctl khpfegnnlq qlvlkicqah fapispgfsr elhslisqlf
      241 qvsprdrpsi nsilkrpfle nlipkyltpe viqeefshml icragapasr hagkvvqkck
      301 iqkvrfqgkc pprsrisvpi krnailhrne wrppagaqka rsikmierpk iaavcghydy
      361 yyaqldmlrr rahkpsyhpi pqentgvedy gqetrhgpsp sqwpaeylqr kfeaqqyklk
      421 vekqlglrps saepnynqrq elrsngeepr fqelpfrkne mkeqeywkql eeirqqyhnd
      481 mkeirkkmgr epeenskish ktylvkksnl pvhqdasege apvqdiekdl kqmrlqntke
      541 sknpeqkyka kkgvkfeinl dkcisdenil qeeeamdipn etltfedgmk fkeyecvkeh
      601 gdytdkafek lhcpeagfst qtvaavgnrr qwdggapqtl lqmmavadit stcptgpdng
      661 qviviegipg nrkqwrheap gtlmsvlaaa hltsssfsad eefamgtlkq wlpkeedegk
      721 vemvsgievd eeqleprsdd ddtnfeesed elrdevveyl eklatfkgee kteeasstsk
      781 dsrksrereg ismqkseelr eglenistts ndhicitded qgtsttsqni qv
//
LOCUS       XP_047286249             790 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase Nek5 isoform X7 [Homo sapiens].
ACCESSION   XP_047286249
VERSION     XP_047286249.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430293.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..790
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..790
                     /product="serine/threonine-protein kinase Nek5 isoform X7"
                     /calculated_mol_wt=90973
     Region          3..259
                     /region_name="STKc_Nek5"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     Never In Mitosis gene A (NIMA)-related kinase 5; cd08225"
                     /db_xref="CDD:173765"
     Site            order(10..14,18,31,33,64,80..83,87,89,128,130,132..133,
                     135,147,150,152,166..169)
                     /site_type="active"
                     /db_xref="CDD:173765"
     Site            order(10..11,13..14,18,31,33,64,81..83,87,133,135,152)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:173765"
     Site            order(14,87,89,128,130,132,150,166..169)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:173765"
     Site            146..169
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:173765"
     CDS             1..790
                     /gene="NEK5"
                     /coded_by="XM_047430293.1:136..2508"
                     /db_xref="GeneID:341676"
                     /db_xref="HGNC:HGNC:7748"
                     /db_xref="MIM:616731"
ORIGIN      
        1 mdkydvikai gqgafgkayl akgksdskhc vikeinfekm piqekeaskk evillekmkh
       61 pnivaffnsf qengrlfivm eycdggdlmk rinrqrgvlf sedqilgwfv qislglkhih
      121 drkilhrdik aqniflskng mvaklgdfgi arvlnnsmel artcigtpyy lspeicqnkp
      181 ynnktdiwsl gcvlyelctl khpfegnnlq qlvlkicqah fapispgfsr elhslisqlf
      241 qvsprdrpsi nsilkrpfle nlipkyltpe viqeefshml icragapasr hagkvvqkck
      301 iqkvrfqgkc pprsrisvpi krnailhrne wrppagaqka rsikmierpk iaavcghydy
      361 yyaqldmlrr rahkpsyhpi pqentgvedy gqetrhgpsp sqwpaeylqr kfeaqqyklk
      421 vekqlglrps saepnynqrq elrsngeepr fqelpfrkne mkeqeywkql eeirqqyhnd
      481 mkeirkkmgr epeenskish ktylvkksnl pvhqdasege apvqdiekdl kqmrlqntke
      541 sknpeqkyka kkgvkfeinl dkcisdenil qeeeamdipn etltfedgmk fkeyecvkeh
      601 gdytdkafek lhcpeadgqv iviegipgnr kqwrheapgt lmsvlaaahl tsssfsadee
      661 famgtlkqwl pkeedegkve mvsgievdee qleprsdddd tnfeesedel rdevveylek
      721 latfkgeekt eeasstskds rksreregis mqkseelreg lenisttsnd hicitdedqg
      781 tsttsqniqv
//
LOCUS       XP_047286250             753 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase Nek5 isoform X8 [Homo sapiens].
ACCESSION   XP_047286250
VERSION     XP_047286250.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430294.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..753
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..753
                     /product="serine/threonine-protein kinase Nek5 isoform X8"
                     /calculated_mol_wt=86304
     Region          <1..180
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..753
                     /gene="NEK5"
                     /coded_by="XM_047430294.1:112..2373"
                     /db_xref="GeneID:341676"
                     /db_xref="HGNC:HGNC:7748"
                     /db_xref="MIM:616731"
ORIGIN      
        1 meycdggdlm krinrqrgvl fsedqilgwf vqislglkhi hdrkilhrdi kaqniflskn
       61 gmvaklgdfg iarvlnnsme lartcigtpy ylspeicqnk pynnktdiws lgcvlyelct
      121 lkhpfegnnl qqlvlkicqa hfapispgfs relhslisql fqvsprdrps insilkrpfl
      181 enlipkyltp eviqeefshm licragapas rhagkvvqkc kiqkvrfqgk cpprsrisvp
      241 ikrnailhrn ewrppagaqk arsikmierp kiaavcghyd yyyaqldmlr rrahkpsyhp
      301 ipqentgved ygqetrhgps psqwpaeylq rkfeaqqykl kvekqlglrp ssaepnynqr
      361 qelrsngeep rfqelpfrkn emkeqeywkq leeirqqyhn dmkeirkkmg repeenskis
      421 hktylvkksn lpvhqdaseg eapvqdiekd lkqmrlqntk esknpeqkyk akkgvkfein
      481 ldkcisdeni lqeeeamdip netltfedgm kfkeyecvke hgdytdkafe klhcpeagfs
      541 tqtvaavgnr rqwdggapqt llqmmavadi tstcptgpdn gqviviegip gnrkqwrhea
      601 pgtlmsvlaa ahltsssfsa deefamgtlk qwlpkeedeg kvemvsgiev deeqleprsd
      661 dddtnfeese delrdevvey leklatfkge ekteeassts kdsrksrere gismqkseel
      721 reglenistt sndhicitde dqgtsttsqn iqv
//
LOCUS       XP_016876045             737 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase Nek5 isoform X9 [Homo sapiens].
ACCESSION   XP_016876045
VERSION     XP_016876045.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020556.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..737
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..737
                     /product="serine/threonine-protein kinase Nek5 isoform X9"
                     /calculated_mol_wt=84417
     Region          75..331
                     /region_name="STKc_Nek5"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     Never In Mitosis gene A (NIMA)-related kinase 5; cd08225"
                     /db_xref="CDD:173765"
     Site            order(82..86,90,103,105,136,152..155,159,161,200,202,
                     204..205,207,219,222,224,238..241)
                     /site_type="active"
                     /db_xref="CDD:173765"
     Site            order(82..83,85..86,90,103,105,136,153..155,159,205,207,
                     224)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:173765"
     Site            order(86,159,161,200,202,204,222,238..241)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:173765"
     Site            218..241
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:173765"
     CDS             1..737
                     /gene="NEK5"
                     /coded_by="XM_017020556.2:126..2339"
                     /db_xref="GeneID:341676"
                     /db_xref="HGNC:HGNC:7748"
                     /db_xref="MIM:616731"
ORIGIN      
        1 mefrpgaaga aqkrpsvlgc vgvasrarrs lwqrstrggr vrlsvatkkv iclclgkagr
       61 kvlakklspl etmdkydvik aigqgafgka ylakgksdsk hcvikeinfe kmpiqekeas
      121 kkevillekm khpnivaffn sfqengrlfi vmeycdggdl mkrinrqrgv lfsedqilgw
      181 fvqislglkh ihdrkilhrd ikaqniflsk ngmvaklgdf giarvlnnsm elartcigtp
      241 yylspeicqn kpynnktdiw slgcvlyelc tlkhpfegnn lqqlvlkicq ahfapispgf
      301 srelhslisq lfqvsprdrp sinsilkrpf lenlipkylt peviqeefsh mlicragapa
      361 srhagkvvqk ckiqkvrfqg kcpprsrisv pikrnailhr newrppagaq karsikmier
      421 pkiaavcghy dyyyaqldml rrrahkpsyh pipqentgve dygqetrhgp spsqwpaeyl
      481 qrkfeaqqyk lkvekqlglr pssaepnynq rqelrsngee prfqelpfrk nemkeqeywk
      541 qleeirqqyh ndmkeirkkm grepeenski shktylvkks nlpvhqdase geapvqdiek
      601 dlkqmrlqnt kesknpeqky kakkgvkfei nldkcisden ilqeeeamdi pnetltfedg
      661 mkfkeyecvk ehgdytdkaf eklhcpeaal asprssrlts lshcllgssm dkccqylkls
      721 cvkssssvlf pvtlyfg
//
LOCUS       XP_011533368             697 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase Nek5 isoform X10 [Homo sapiens].
ACCESSION   XP_011533368
VERSION     XP_011533368.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535066.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..697
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..697
                     /product="serine/threonine-protein kinase Nek5 isoform
                     X10"
                     /calculated_mol_wt=80075
     Region          75..331
                     /region_name="STKc_Nek5"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     Never In Mitosis gene A (NIMA)-related kinase 5; cd08225"
                     /db_xref="CDD:173765"
     Site            order(82..86,90,103,105,136,152..155,159,161,200,202,
                     204..205,207,219,222,224,238..241)
                     /site_type="active"
                     /db_xref="CDD:173765"
     Site            order(82..83,85..86,90,103,105,136,153..155,159,205,207,
                     224)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:173765"
     Site            order(86,159,161,200,202,204,222,238..241)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:173765"
     Site            218..241
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:173765"
     CDS             1..697
                     /gene="NEK5"
                     /coded_by="XM_011535066.3:126..2219"
                     /db_xref="GeneID:341676"
                     /db_xref="HGNC:HGNC:7748"
                     /db_xref="MIM:616731"
ORIGIN      
        1 mefrpgaaga aqkrpsvlgc vgvasrarrs lwqrstrggr vrlsvatkkv iclclgkagr
       61 kvlakklspl etmdkydvik aigqgafgka ylakgksdsk hcvikeinfe kmpiqekeas
      121 kkevillekm khpnivaffn sfqengrlfi vmeycdggdl mkrinrqrgv lfsedqilgw
      181 fvqislglkh ihdrkilhrd ikaqniflsk ngmvaklgdf giarvlnnsm elartcigtp
      241 yylspeicqn kpynnktdiw slgcvlyelc tlkhpfegnn lqqlvlkicq ahfapispgf
      301 srelhslisq lfqvsprdrp sinsilkrpf lenlipkylt peviqeefsh mlicragapa
      361 srhagkvvqk ckiqkvrfqg kcpprsrisv pikrnailhr newrppagaq karsikmier
      421 pkiaavcghy dyyyaqldml rrrahkpsyh pipqentgve dygqetrhgp spsqwpaeyl
      481 qrkfeaqqyk lkvekqlglr pssaepnynq rqelrsngee prfqelpfrk nemkeqeywk
      541 qleeirqqyh ndmkeirkkm grepeenski shktylvkks nlpvhqdase geapvqdiek
      601 dlkqmrlqnt kesknpeqky kakkgvkfei nldkcisden ilqeeeamdi pnetltfedg
      661 mkfkeyecvk ehgdytdkaf eklhcpeaap wtsvasi
//
LOCUS       XP_047286251             692 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase Nek5 isoform X11 [Homo sapiens].
ACCESSION   XP_047286251
VERSION     XP_047286251.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430295.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..692
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..692
                     /product="serine/threonine-protein kinase Nek5 isoform
                     X11"
                     /calculated_mol_wt=79169
     Region          <1..119
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..692
                     /gene="NEK5"
                     /coded_by="XM_047430295.1:196..2274"
                     /db_xref="GeneID:341676"
                     /db_xref="HGNC:HGNC:7748"
                     /db_xref="MIM:616731"
ORIGIN      
        1 mvaklgdfgi arvlnnsmel artcigtpyy lspeicqnkp ynnktdiwsl gcvlyelctl
       61 khpfegnnlq qlvlkicqah fapispgfsr elhslisqlf qvsprdrpsi nsilkrpfle
      121 nlipkyltpe viqeefshml icragapasr hagkvvqkck iqkvrfqgkc pprsrisvpi
      181 krnailhrne wrppagaqka rsikmierpk iaavcghydy yyaqldmlrr rahkpsyhpi
      241 pqentgvedy gqetrhgpsp sqwpaeylqr kfeaqqyklk vekqlglrps saepnynqrq
      301 elrsngeepr fqelpfrkne mkeqeywkql eeirqqyhnd mkeirkkmgr epeenskish
      361 ktylvkksnl pvhqdasege apvqdiekdl kqmrlqntke sknpeqkyka kkgvkfeinl
      421 dkcisdenil qeeeamdipn etltfedgmk fkeyecvkeh gdytdkafek lhcpeagfst
      481 qtvaavgnrr qwdggapqtl lqmmavadit stcptgpdng qviviegipg nrkqwrheap
      541 gtlmsvlaaa hltsssfsad eefamgtlkq wlpkeedegk vemvsgievd eeqleprsdd
      601 ddtnfeesed elrdevveyl eklatfkgee kteeasstsk dsrksrereg ismqkseelr
      661 eglenistts ndhicitded qgtsttsqni qv
//
LOCUS       XP_006719871             598 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase Nek5 isoform X12 [Homo sapiens].
ACCESSION   XP_006719871
VERSION     XP_006719871.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006719808.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Mar 12, 2015 this sequence version replaced XP_006719871.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..598
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..598
                     /product="serine/threonine-protein kinase Nek5 isoform
                     X12"
                     /calculated_mol_wt=68930
     Region          75..331
                     /region_name="STKc_Nek5"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     Never In Mitosis gene A (NIMA)-related kinase 5; cd08225"
                     /db_xref="CDD:173765"
     Site            order(82..86,90,103,105,136,152..155,159,161,200,202,
                     204..205,207,219,222,224,238..241)
                     /site_type="active"
                     /db_xref="CDD:173765"
     Site            order(82..83,85..86,90,103,105,136,153..155,159,205,207,
                     224)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:173765"
     Site            order(86,159,161,200,202,204,222,238..241)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:173765"
     Site            218..241
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:173765"
     CDS             1..598
                     /gene="NEK5"
                     /coded_by="XM_006719808.5:126..1922"
                     /db_xref="GeneID:341676"
                     /db_xref="HGNC:HGNC:7748"
                     /db_xref="MIM:616731"
ORIGIN      
        1 mefrpgaaga aqkrpsvlgc vgvasrarrs lwqrstrggr vrlsvatkkv iclclgkagr
       61 kvlakklspl etmdkydvik aigqgafgka ylakgksdsk hcvikeinfe kmpiqekeas
      121 kkevillekm khpnivaffn sfqengrlfi vmeycdggdl mkrinrqrgv lfsedqilgw
      181 fvqislglkh ihdrkilhrd ikaqniflsk ngmvaklgdf giarvlnnsm elartcigtp
      241 yylspeicqn kpynnktdiw slgcvlyelc tlkhpfegnn lqqlvlkicq ahfapispgf
      301 srelhslisq lfqvsprdrp sinsilkrpf lenlipkylt peviqeefsh mlicragapa
      361 srhagkvvqk ckiqkvrfqg kcpprsrisv pikrnailhr newrppagaq karsikmier
      421 pkiaavcghy dyyyaqldml rrrahkpsyh pipqentgve dygqetrhgp spsqwpaeyl
      481 qrkfeaqqyk lkvekqlglr pssaepnynq rqelrsngee prfqelpfrk nemkeqeywk
      541 qleeirqqyh ndmkeirkkm grepeescqt slelqfimvy erlhkiiris eilrngyy
//
LOCUS       XP_011533370             483 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase Nek5 isoform X13 [Homo sapiens].
ACCESSION   XP_011533370
VERSION     XP_011533370.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535068.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..483
                     /product="serine/threonine-protein kinase Nek5 isoform
                     X13"
                     /calculated_mol_wt=54712
     Region          75..331
                     /region_name="STKc_Nek5"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     Never In Mitosis gene A (NIMA)-related kinase 5; cd08225"
                     /db_xref="CDD:173765"
     Site            order(82..86,90,103,105,136,152..155,159,161,200,202,
                     204..205,207,219,222,224,238..241)
                     /site_type="active"
                     /db_xref="CDD:173765"
     Site            order(82..83,85..86,90,103,105,136,153..155,159,205,207,
                     224)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:173765"
     Site            order(86,159,161,200,202,204,222,238..241)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:173765"
     Site            218..241
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:173765"
     CDS             1..483
                     /gene="NEK5"
                     /coded_by="XM_011535068.3:126..1577"
                     /db_xref="GeneID:341676"
                     /db_xref="HGNC:HGNC:7748"
                     /db_xref="MIM:616731"
ORIGIN      
        1 mefrpgaaga aqkrpsvlgc vgvasrarrs lwqrstrggr vrlsvatkkv iclclgkagr
       61 kvlakklspl etmdkydvik aigqgafgka ylakgksdsk hcvikeinfe kmpiqekeas
      121 kkevillekm khpnivaffn sfqengrlfi vmeycdggdl mkrinrqrgv lfsedqilgw
      181 fvqislglkh ihdrkilhrd ikaqniflsk ngmvaklgdf giarvlnnsm elartcigtp
      241 yylspeicqn kpynnktdiw slgcvlyelc tlkhpfegnn lqqlvlkicq ahfapispgf
      301 srelhslisq lfqvsprdrp sinsilkrpf lenlipkylt peviqeefsh mlicragapa
      361 srhagkvvqk ckiqkvrfqg kcpprsrisv pikrnailhr newrppagaq karsikmier
      421 pkiaavcghy dyyyaqldml rrrahkpsyh pipqentgve dygqetrhgp spsqwkfcqk
      481 kdt
//
LOCUS       XP_016876050             497 aa            linear   PRI 05-AUG-2025
DEFINITION  importin subunit alpha-4 isoform X1 [Homo sapiens].
ACCESSION   XP_016876050
VERSION     XP_016876050.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020561.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..497
                     /product="importin subunit alpha-4 isoform X1"
                     /calculated_mol_wt=54897
     Region          1..497
                     /region_name="SRP1"
                     /note="Karyopherin (importin) alpha [Intracellular
                     trafficking and secretion]; COG5064"
                     /db_xref="CDD:227396"
     Region          49..74
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          85..118
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Site            order(109,113,117,151,155,159,194,198,202)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293788"
     Region          126..162
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          168..203
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          220..245
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Site            order(236,240,244,278,282,286,320,324,328)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293788"
     Region          253..289
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          295..329
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          337..371
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          380..414
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     CDS             1..497
                     /gene="KPNA3"
                     /gene_synonym="hSRP1; IPOA4; SPG88; SRP1; SRP1gamma; SRP4"
                     /coded_by="XM_017020561.2:681..2174"
                     /db_xref="GeneID:3839"
                     /db_xref="HGNC:HGNC:6396"
                     /db_xref="MIM:601892"
ORIGIN      
        1 mrrhrnevtv elrknkrdeh llkkrnvpqe esledsdvda dfkaqnvtle ailqnatsdn
       61 pvvqlsavqa arkllssdrn ppiddliksg ilpilvkcle rddnpslqfe aawaltnias
      121 gtsaqtqavv qsnavplflr llrsphqnvc eqavwalgni igdgpqcrdy vislgvvkpl
      181 lsfispsipi tflrnvtwvi vnlcrnkdpp ppmetvqeil palcvliyht dinilvdtvw
      241 alsyltdggn eqiqmvidsg vvpflvplls hqevkvqtaa lravgnivtg tdeqtqvvln
      301 cdvlshfpnl lshpkekink eavwflsnit agnqqqvqav idaglipmii hqlakgdfgt
      361 qkeaawaisn ltisgrkdqv eylvqqnvip pfcnllsvkd sqvvqvvldg lknilimagd
      421 eastiaeiie ecgglekiev lqqhenediy klafeiidqy fsgddidedp clipeatqgg
      481 tynfdptanl qtkefnf
//
LOCUS       XP_005254109            1115 aa            linear   PRI 05-AUG-2025
DEFINITION  importin-5 isoform X1 [Homo sapiens].
ACCESSION   XP_005254109
VERSION     XP_005254109.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254052.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1115
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1115
                     /product="importin-5 isoform X1"
                     /calculated_mol_wt=125415
     Region          31..>652
                     /region_name="KAP95"
                     /note="Karyopherin (importin) beta [Intracellular
                     trafficking and secretion]; COG5215"
                     /db_xref="CDD:227540"
     Region          111..133
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          150..178
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          195..217
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          235..263
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          275..316
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          286..375
                     /region_name="Importin_rep_4"
                     /note="Importin repeat; pfam18808"
                     /db_xref="CDD:408579"
     Site            order(355..356,359,362..363,394..395,398,401..402,405,
                     435..436,439,442..443,446,478..479,482,485..486,528..529,
                     532,535..536)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          373..405
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          417..447
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          459..486
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          500..537
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          549..582
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          783..892
                     /region_name="Importin_rep_6"
                     /note="Importin repeat 6; pfam18829"
                     /db_xref="CDD:465881"
     Region          883..908
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Site            order(900..901,904,907..908,941..942,945,948..949,954,
                     982..983,992,995..996,999,1025..1026,1029,1032..1033)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          921..954
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          937..984
                     /region_name="HEAT_EZ"
                     /note="HEAT-like repeat; pfam13513"
                     /db_xref="CDD:463906"
     Region          964..1000
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          1009..1033
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          1023..1069
                     /region_name="Importin_rep_5"
                     /note="Importin repeat; pfam18816"
                     /db_xref="CDD:465877"
     CDS             1..1115
                     /gene="IPO5"
                     /gene_synonym="IMB3; imp5; KPNB3; Pse1; RANBP5"
                     /coded_by="XM_005254052.4:101..3448"
                     /db_xref="GeneID:3843"
                     /db_xref="HGNC:HGNC:6402"
                     /db_xref="MIM:602008"
ORIGIN      
        1 mpedqvgkle atentisama aaaaeqqqfy lllgnllspd nvvrkqaeet yenipgqski
       61 tfllqairnt taaeearqma avllrrllss afdevypalp sdvqtaikse llmiiqmetq
      121 ssmrkkvcdi aaelarnlid edgnnqwpeg lkflfdsvss qnvglreaal hifwnfpgif
      181 gnqqqhyldv ikrmlvqcmq dqehpsirtl sarataafil anehnvalfk hfadllpgfl
      241 qavndscyqn ddsvlkslve iadtvpkylr phleatlqls lklcgdtsln nmqrqlalev
      301 ivtlsetaaa mlrkhtniva qtipqmlamm vdleededwa nadeledddf dsnavagesa
      361 ldrmacglgg klvlpmikeh imqmlqnpdw kyrhaglmal saigegchqq megilneivn
      421 fvllflqdph prvryaacna vgqmatdfap gfqkkfhekv iaallqtmed qgnqrvqaha
      481 aaalinfted cpksllipyl dnlvkhlhsi mvlklqeliq kgtklvleqv vtsiasvadt
      541 aeekfvpyyd lfmpslkhiv enavqkelrl lrgktiecis liglavgkek fmqdasdvmq
      601 lllktqtdfn dmedddpqis ymisawarmc kilgkefqqy lpvvmgplmk tasikpeval
      661 ldtqdmenms dddgwefvnl gdqqsfgikt agleekstac qmlvcyakel kegfveyteq
      721 vvklmvpllk fyfhdgvrva aaesmpllle carvrgpeyl tqmwhfmcda likaigtepd
      781 sdvlseimhs fakcievmgd gclnnehfee lggilkakle ehfknqelrq vkrqdedyde
      841 qveeslqded dndvyiltkv sdilhsifss ykekvlpwfe qllplivnli cphrpwpdrq
      901 wglcifddvi ehcspasfky aeyflrpmlq yvcdnspevr qaaayglgvm aqyggdnyrp
      961 fctealpllv rviqsadskt kenvnatenc isavgkimkf kpdcvnveev lphwlswlpl
     1021 hedkeeavqt fnylcdlies nhpivlgpnn tnlpkifsii aegemheaik hedpcakrla
     1081 nvvrqvqtsg glwteciaql speqqaaiqe llnsa
//
LOCUS       XP_024305114            1115 aa            linear   PRI 05-AUG-2025
DEFINITION  importin-5 isoform X1 [Homo sapiens].
ACCESSION   XP_024305114
VERSION     XP_024305114.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449346.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1115
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1115
                     /product="importin-5 isoform X1"
                     /calculated_mol_wt=125415
     Region          31..>652
                     /region_name="KAP95"
                     /note="Karyopherin (importin) beta [Intracellular
                     trafficking and secretion]; COG5215"
                     /db_xref="CDD:227540"
     Region          111..133
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          150..178
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          195..217
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          235..263
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          275..316
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          286..375
                     /region_name="Importin_rep_4"
                     /note="Importin repeat; pfam18808"
                     /db_xref="CDD:408579"
     Site            order(355..356,359,362..363,394..395,398,401..402,405,
                     435..436,439,442..443,446,478..479,482,485..486,528..529,
                     532,535..536)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          373..405
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          417..447
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          459..486
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          500..537
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          549..582
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          783..892
                     /region_name="Importin_rep_6"
                     /note="Importin repeat 6; pfam18829"
                     /db_xref="CDD:465881"
     Region          883..908
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Site            order(900..901,904,907..908,941..942,945,948..949,954,
                     982..983,992,995..996,999,1025..1026,1029,1032..1033)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          921..954
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          937..984
                     /region_name="HEAT_EZ"
                     /note="HEAT-like repeat; pfam13513"
                     /db_xref="CDD:463906"
     Region          964..1000
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          1009..1033
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          1023..1069
                     /region_name="Importin_rep_5"
                     /note="Importin repeat; pfam18816"
                     /db_xref="CDD:465877"
     CDS             1..1115
                     /gene="IPO5"
                     /gene_synonym="IMB3; imp5; KPNB3; Pse1; RANBP5"
                     /coded_by="XM_024449346.2:197..3544"
                     /db_xref="GeneID:3843"
                     /db_xref="HGNC:HGNC:6402"
                     /db_xref="MIM:602008"
ORIGIN      
        1 mpedqvgkle atentisama aaaaeqqqfy lllgnllspd nvvrkqaeet yenipgqski
       61 tfllqairnt taaeearqma avllrrllss afdevypalp sdvqtaikse llmiiqmetq
      121 ssmrkkvcdi aaelarnlid edgnnqwpeg lkflfdsvss qnvglreaal hifwnfpgif
      181 gnqqqhyldv ikrmlvqcmq dqehpsirtl sarataafil anehnvalfk hfadllpgfl
      241 qavndscyqn ddsvlkslve iadtvpkylr phleatlqls lklcgdtsln nmqrqlalev
      301 ivtlsetaaa mlrkhtniva qtipqmlamm vdleededwa nadeledddf dsnavagesa
      361 ldrmacglgg klvlpmikeh imqmlqnpdw kyrhaglmal saigegchqq megilneivn
      421 fvllflqdph prvryaacna vgqmatdfap gfqkkfhekv iaallqtmed qgnqrvqaha
      481 aaalinfted cpksllipyl dnlvkhlhsi mvlklqeliq kgtklvleqv vtsiasvadt
      541 aeekfvpyyd lfmpslkhiv enavqkelrl lrgktiecis liglavgkek fmqdasdvmq
      601 lllktqtdfn dmedddpqis ymisawarmc kilgkefqqy lpvvmgplmk tasikpeval
      661 ldtqdmenms dddgwefvnl gdqqsfgikt agleekstac qmlvcyakel kegfveyteq
      721 vvklmvpllk fyfhdgvrva aaesmpllle carvrgpeyl tqmwhfmcda likaigtepd
      781 sdvlseimhs fakcievmgd gclnnehfee lggilkakle ehfknqelrq vkrqdedyde
      841 qveeslqded dndvyiltkv sdilhsifss ykekvlpwfe qllplivnli cphrpwpdrq
      901 wglcifddvi ehcspasfky aeyflrpmlq yvcdnspevr qaaayglgvm aqyggdnyrp
      961 fctealpllv rviqsadskt kenvnatenc isavgkimkf kpdcvnveev lphwlswlpl
     1021 hedkeeavqt fnylcdlies nhpivlgpnn tnlpkifsii aegemheaik hedpcakrla
     1081 nvvrqvqtsg glwteciaql speqqaaiqe llnsa
//
LOCUS       XP_011519389            1115 aa            linear   PRI 05-AUG-2025
DEFINITION  importin-5 isoform X1 [Homo sapiens].
ACCESSION   XP_011519389
VERSION     XP_011519389.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521087.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1115
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1115
                     /product="importin-5 isoform X1"
                     /calculated_mol_wt=125415
     Region          31..>652
                     /region_name="KAP95"
                     /note="Karyopherin (importin) beta [Intracellular
                     trafficking and secretion]; COG5215"
                     /db_xref="CDD:227540"
     Region          111..133
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          150..178
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          195..217
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          235..263
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          275..316
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          286..375
                     /region_name="Importin_rep_4"
                     /note="Importin repeat; pfam18808"
                     /db_xref="CDD:408579"
     Site            order(355..356,359,362..363,394..395,398,401..402,405,
                     435..436,439,442..443,446,478..479,482,485..486,528..529,
                     532,535..536)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          373..405
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          417..447
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          459..486
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          500..537
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          549..582
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          783..892
                     /region_name="Importin_rep_6"
                     /note="Importin repeat 6; pfam18829"
                     /db_xref="CDD:465881"
     Region          883..908
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Site            order(900..901,904,907..908,941..942,945,948..949,954,
                     982..983,992,995..996,999,1025..1026,1029,1032..1033)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          921..954
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          937..984
                     /region_name="HEAT_EZ"
                     /note="HEAT-like repeat; pfam13513"
                     /db_xref="CDD:463906"
     Region          964..1000
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          1009..1033
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          1023..1069
                     /region_name="Importin_rep_5"
                     /note="Importin repeat; pfam18816"
                     /db_xref="CDD:465877"
     CDS             1..1115
                     /gene="IPO5"
                     /gene_synonym="IMB3; imp5; KPNB3; Pse1; RANBP5"
                     /coded_by="XM_011521087.3:238..3585"
                     /db_xref="GeneID:3843"
                     /db_xref="HGNC:HGNC:6402"
                     /db_xref="MIM:602008"
ORIGIN      
        1 mpedqvgkle atentisama aaaaeqqqfy lllgnllspd nvvrkqaeet yenipgqski
       61 tfllqairnt taaeearqma avllrrllss afdevypalp sdvqtaikse llmiiqmetq
      121 ssmrkkvcdi aaelarnlid edgnnqwpeg lkflfdsvss qnvglreaal hifwnfpgif
      181 gnqqqhyldv ikrmlvqcmq dqehpsirtl sarataafil anehnvalfk hfadllpgfl
      241 qavndscyqn ddsvlkslve iadtvpkylr phleatlqls lklcgdtsln nmqrqlalev
      301 ivtlsetaaa mlrkhtniva qtipqmlamm vdleededwa nadeledddf dsnavagesa
      361 ldrmacglgg klvlpmikeh imqmlqnpdw kyrhaglmal saigegchqq megilneivn
      421 fvllflqdph prvryaacna vgqmatdfap gfqkkfhekv iaallqtmed qgnqrvqaha
      481 aaalinfted cpksllipyl dnlvkhlhsi mvlklqeliq kgtklvleqv vtsiasvadt
      541 aeekfvpyyd lfmpslkhiv enavqkelrl lrgktiecis liglavgkek fmqdasdvmq
      601 lllktqtdfn dmedddpqis ymisawarmc kilgkefqqy lpvvmgplmk tasikpeval
      661 ldtqdmenms dddgwefvnl gdqqsfgikt agleekstac qmlvcyakel kegfveyteq
      721 vvklmvpllk fyfhdgvrva aaesmpllle carvrgpeyl tqmwhfmcda likaigtepd
      781 sdvlseimhs fakcievmgd gclnnehfee lggilkakle ehfknqelrq vkrqdedyde
      841 qveeslqded dndvyiltkv sdilhsifss ykekvlpwfe qllplivnli cphrpwpdrq
      901 wglcifddvi ehcspasfky aeyflrpmlq yvcdnspevr qaaayglgvm aqyggdnyrp
      961 fctealpllv rviqsadskt kenvnatenc isavgkimkf kpdcvnveev lphwlswlpl
     1021 hedkeeavqt fnylcdlies nhpivlgpnn tnlpkifsii aegemheaik hedpcakrla
     1081 nvvrqvqtsg glwteciaql speqqaaiqe llnsa
//
LOCUS       XP_011519390            1115 aa            linear   PRI 05-AUG-2025
DEFINITION  importin-5 isoform X1 [Homo sapiens].
ACCESSION   XP_011519390
VERSION     XP_011519390.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521088.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1115
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1115
                     /product="importin-5 isoform X1"
                     /calculated_mol_wt=125415
     Region          31..>652
                     /region_name="KAP95"
                     /note="Karyopherin (importin) beta [Intracellular
                     trafficking and secretion]; COG5215"
                     /db_xref="CDD:227540"
     Region          111..133
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          150..178
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          195..217
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          235..263
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          275..316
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          286..375
                     /region_name="Importin_rep_4"
                     /note="Importin repeat; pfam18808"
                     /db_xref="CDD:408579"
     Site            order(355..356,359,362..363,394..395,398,401..402,405,
                     435..436,439,442..443,446,478..479,482,485..486,528..529,
                     532,535..536)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          373..405
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          417..447
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          459..486
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          500..537
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          549..582
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          783..892
                     /region_name="Importin_rep_6"
                     /note="Importin repeat 6; pfam18829"
                     /db_xref="CDD:465881"
     Region          883..908
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Site            order(900..901,904,907..908,941..942,945,948..949,954,
                     982..983,992,995..996,999,1025..1026,1029,1032..1033)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          921..954
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          937..984
                     /region_name="HEAT_EZ"
                     /note="HEAT-like repeat; pfam13513"
                     /db_xref="CDD:463906"
     Region          964..1000
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          1009..1033
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          1023..1069
                     /region_name="Importin_rep_5"
                     /note="Importin repeat; pfam18816"
                     /db_xref="CDD:465877"
     CDS             1..1115
                     /gene="IPO5"
                     /gene_synonym="IMB3; imp5; KPNB3; Pse1; RANBP5"
                     /coded_by="XM_011521088.3:304..3651"
                     /db_xref="GeneID:3843"
                     /db_xref="HGNC:HGNC:6402"
                     /db_xref="MIM:602008"
ORIGIN      
        1 mpedqvgkle atentisama aaaaeqqqfy lllgnllspd nvvrkqaeet yenipgqski
       61 tfllqairnt taaeearqma avllrrllss afdevypalp sdvqtaikse llmiiqmetq
      121 ssmrkkvcdi aaelarnlid edgnnqwpeg lkflfdsvss qnvglreaal hifwnfpgif
      181 gnqqqhyldv ikrmlvqcmq dqehpsirtl sarataafil anehnvalfk hfadllpgfl
      241 qavndscyqn ddsvlkslve iadtvpkylr phleatlqls lklcgdtsln nmqrqlalev
      301 ivtlsetaaa mlrkhtniva qtipqmlamm vdleededwa nadeledddf dsnavagesa
      361 ldrmacglgg klvlpmikeh imqmlqnpdw kyrhaglmal saigegchqq megilneivn
      421 fvllflqdph prvryaacna vgqmatdfap gfqkkfhekv iaallqtmed qgnqrvqaha
      481 aaalinfted cpksllipyl dnlvkhlhsi mvlklqeliq kgtklvleqv vtsiasvadt
      541 aeekfvpyyd lfmpslkhiv enavqkelrl lrgktiecis liglavgkek fmqdasdvmq
      601 lllktqtdfn dmedddpqis ymisawarmc kilgkefqqy lpvvmgplmk tasikpeval
      661 ldtqdmenms dddgwefvnl gdqqsfgikt agleekstac qmlvcyakel kegfveyteq
      721 vvklmvpllk fyfhdgvrva aaesmpllle carvrgpeyl tqmwhfmcda likaigtepd
      781 sdvlseimhs fakcievmgd gclnnehfee lggilkakle ehfknqelrq vkrqdedyde
      841 qveeslqded dndvyiltkv sdilhsifss ykekvlpwfe qllplivnli cphrpwpdrq
      901 wglcifddvi ehcspasfky aeyflrpmlq yvcdnspevr qaaayglgvm aqyggdnyrp
      961 fctealpllv rviqsadskt kenvnatenc isavgkimkf kpdcvnveev lphwlswlpl
     1021 hedkeeavqt fnylcdlies nhpivlgpnn tnlpkifsii aegemheaik hedpcakrla
     1081 nvvrqvqtsg glwteciaql speqqaaiqe llnsa
//
LOCUS       XP_016876051            1115 aa            linear   PRI 05-AUG-2025
DEFINITION  importin-5 isoform X1 [Homo sapiens].
ACCESSION   XP_016876051
VERSION     XP_016876051.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020562.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1115
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1115
                     /product="importin-5 isoform X1"
                     /calculated_mol_wt=125415
     Region          31..>652
                     /region_name="KAP95"
                     /note="Karyopherin (importin) beta [Intracellular
                     trafficking and secretion]; COG5215"
                     /db_xref="CDD:227540"
     Region          111..133
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          150..178
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          195..217
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          235..263
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          275..316
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          286..375
                     /region_name="Importin_rep_4"
                     /note="Importin repeat; pfam18808"
                     /db_xref="CDD:408579"
     Site            order(355..356,359,362..363,394..395,398,401..402,405,
                     435..436,439,442..443,446,478..479,482,485..486,528..529,
                     532,535..536)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          373..405
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          417..447
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          459..486
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          500..537
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          549..582
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          783..892
                     /region_name="Importin_rep_6"
                     /note="Importin repeat 6; pfam18829"
                     /db_xref="CDD:465881"
     Region          883..908
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Site            order(900..901,904,907..908,941..942,945,948..949,954,
                     982..983,992,995..996,999,1025..1026,1029,1032..1033)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          921..954
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          937..984
                     /region_name="HEAT_EZ"
                     /note="HEAT-like repeat; pfam13513"
                     /db_xref="CDD:463906"
     Region          964..1000
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          1009..1033
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          1023..1069
                     /region_name="Importin_rep_5"
                     /note="Importin repeat; pfam18816"
                     /db_xref="CDD:465877"
     CDS             1..1115
                     /gene="IPO5"
                     /gene_synonym="IMB3; imp5; KPNB3; Pse1; RANBP5"
                     /coded_by="XM_017020562.2:178..3525"
                     /db_xref="GeneID:3843"
                     /db_xref="HGNC:HGNC:6402"
                     /db_xref="MIM:602008"
ORIGIN      
        1 mpedqvgkle atentisama aaaaeqqqfy lllgnllspd nvvrkqaeet yenipgqski
       61 tfllqairnt taaeearqma avllrrllss afdevypalp sdvqtaikse llmiiqmetq
      121 ssmrkkvcdi aaelarnlid edgnnqwpeg lkflfdsvss qnvglreaal hifwnfpgif
      181 gnqqqhyldv ikrmlvqcmq dqehpsirtl sarataafil anehnvalfk hfadllpgfl
      241 qavndscyqn ddsvlkslve iadtvpkylr phleatlqls lklcgdtsln nmqrqlalev
      301 ivtlsetaaa mlrkhtniva qtipqmlamm vdleededwa nadeledddf dsnavagesa
      361 ldrmacglgg klvlpmikeh imqmlqnpdw kyrhaglmal saigegchqq megilneivn
      421 fvllflqdph prvryaacna vgqmatdfap gfqkkfhekv iaallqtmed qgnqrvqaha
      481 aaalinfted cpksllipyl dnlvkhlhsi mvlklqeliq kgtklvleqv vtsiasvadt
      541 aeekfvpyyd lfmpslkhiv enavqkelrl lrgktiecis liglavgkek fmqdasdvmq
      601 lllktqtdfn dmedddpqis ymisawarmc kilgkefqqy lpvvmgplmk tasikpeval
      661 ldtqdmenms dddgwefvnl gdqqsfgikt agleekstac qmlvcyakel kegfveyteq
      721 vvklmvpllk fyfhdgvrva aaesmpllle carvrgpeyl tqmwhfmcda likaigtepd
      781 sdvlseimhs fakcievmgd gclnnehfee lggilkakle ehfknqelrq vkrqdedyde
      841 qveeslqded dndvyiltkv sdilhsifss ykekvlpwfe qllplivnli cphrpwpdrq
      901 wglcifddvi ehcspasfky aeyflrpmlq yvcdnspevr qaaayglgvm aqyggdnyrp
      961 fctealpllv rviqsadskt kenvnatenc isavgkimkf kpdcvnveev lphwlswlpl
     1021 hedkeeavqt fnylcdlies nhpivlgpnn tnlpkifsii aegemheaik hedpcakrla
     1081 nvvrqvqtsg glwteciaql speqqaaiqe llnsa
//
LOCUS       XP_011519391            1115 aa            linear   PRI 05-AUG-2025
DEFINITION  importin-5 isoform X1 [Homo sapiens].
ACCESSION   XP_011519391
VERSION     XP_011519391.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521089.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1115
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1115
                     /product="importin-5 isoform X1"
                     /calculated_mol_wt=125415
     Region          31..>652
                     /region_name="KAP95"
                     /note="Karyopherin (importin) beta [Intracellular
                     trafficking and secretion]; COG5215"
                     /db_xref="CDD:227540"
     Region          111..133
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          150..178
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          195..217
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          235..263
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          275..316
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          286..375
                     /region_name="Importin_rep_4"
                     /note="Importin repeat; pfam18808"
                     /db_xref="CDD:408579"
     Site            order(355..356,359,362..363,394..395,398,401..402,405,
                     435..436,439,442..443,446,478..479,482,485..486,528..529,
                     532,535..536)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          373..405
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          417..447
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          459..486
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          500..537
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          549..582
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          783..892
                     /region_name="Importin_rep_6"
                     /note="Importin repeat 6; pfam18829"
                     /db_xref="CDD:465881"
     Region          883..908
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Site            order(900..901,904,907..908,941..942,945,948..949,954,
                     982..983,992,995..996,999,1025..1026,1029,1032..1033)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          921..954
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          937..984
                     /region_name="HEAT_EZ"
                     /note="HEAT-like repeat; pfam13513"
                     /db_xref="CDD:463906"
     Region          964..1000
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          1009..1033
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          1023..1069
                     /region_name="Importin_rep_5"
                     /note="Importin repeat; pfam18816"
                     /db_xref="CDD:465877"
     CDS             1..1115
                     /gene="IPO5"
                     /gene_synonym="IMB3; imp5; KPNB3; Pse1; RANBP5"
                     /coded_by="XM_011521089.3:361..3708"
                     /db_xref="GeneID:3843"
                     /db_xref="HGNC:HGNC:6402"
                     /db_xref="MIM:602008"
ORIGIN      
        1 mpedqvgkle atentisama aaaaeqqqfy lllgnllspd nvvrkqaeet yenipgqski
       61 tfllqairnt taaeearqma avllrrllss afdevypalp sdvqtaikse llmiiqmetq
      121 ssmrkkvcdi aaelarnlid edgnnqwpeg lkflfdsvss qnvglreaal hifwnfpgif
      181 gnqqqhyldv ikrmlvqcmq dqehpsirtl sarataafil anehnvalfk hfadllpgfl
      241 qavndscyqn ddsvlkslve iadtvpkylr phleatlqls lklcgdtsln nmqrqlalev
      301 ivtlsetaaa mlrkhtniva qtipqmlamm vdleededwa nadeledddf dsnavagesa
      361 ldrmacglgg klvlpmikeh imqmlqnpdw kyrhaglmal saigegchqq megilneivn
      421 fvllflqdph prvryaacna vgqmatdfap gfqkkfhekv iaallqtmed qgnqrvqaha
      481 aaalinfted cpksllipyl dnlvkhlhsi mvlklqeliq kgtklvleqv vtsiasvadt
      541 aeekfvpyyd lfmpslkhiv enavqkelrl lrgktiecis liglavgkek fmqdasdvmq
      601 lllktqtdfn dmedddpqis ymisawarmc kilgkefqqy lpvvmgplmk tasikpeval
      661 ldtqdmenms dddgwefvnl gdqqsfgikt agleekstac qmlvcyakel kegfveyteq
      721 vvklmvpllk fyfhdgvrva aaesmpllle carvrgpeyl tqmwhfmcda likaigtepd
      781 sdvlseimhs fakcievmgd gclnnehfee lggilkakle ehfknqelrq vkrqdedyde
      841 qveeslqded dndvyiltkv sdilhsifss ykekvlpwfe qllplivnli cphrpwpdrq
      901 wglcifddvi ehcspasfky aeyflrpmlq yvcdnspevr qaaayglgvm aqyggdnyrp
      961 fctealpllv rviqsadskt kenvnatenc isavgkimkf kpdcvnveev lphwlswlpl
     1021 hedkeeavqt fnylcdlies nhpivlgpnn tnlpkifsii aegemheaik hedpcakrla
     1081 nvvrqvqtsg glwteciaql speqqaaiqe llnsa
//
LOCUS       XP_047286252            1115 aa            linear   PRI 05-AUG-2025
DEFINITION  importin-5 isoform X1 [Homo sapiens].
ACCESSION   XP_047286252
VERSION     XP_047286252.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430296.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1115
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1115
                     /product="importin-5 isoform X1"
                     /calculated_mol_wt=125415
     Region          31..>652
                     /region_name="KAP95"
                     /note="Karyopherin (importin) beta [Intracellular
                     trafficking and secretion]; COG5215"
                     /db_xref="CDD:227540"
     Region          111..133
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          150..178
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          195..217
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          235..263
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          275..316
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          286..375
                     /region_name="Importin_rep_4"
                     /note="Importin repeat; pfam18808"
                     /db_xref="CDD:408579"
     Site            order(355..356,359,362..363,394..395,398,401..402,405,
                     435..436,439,442..443,446,478..479,482,485..486,528..529,
                     532,535..536)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          373..405
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          417..447
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          459..486
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          500..537
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          549..582
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          783..892
                     /region_name="Importin_rep_6"
                     /note="Importin repeat 6; pfam18829"
                     /db_xref="CDD:465881"
     Region          883..908
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Site            order(900..901,904,907..908,941..942,945,948..949,954,
                     982..983,992,995..996,999,1025..1026,1029,1032..1033)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          921..954
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          937..984
                     /region_name="HEAT_EZ"
                     /note="HEAT-like repeat; pfam13513"
                     /db_xref="CDD:463906"
     Region          964..1000
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          1009..1033
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          1023..1069
                     /region_name="Importin_rep_5"
                     /note="Importin repeat; pfam18816"
                     /db_xref="CDD:465877"
     CDS             1..1115
                     /gene="IPO5"
                     /gene_synonym="IMB3; imp5; KPNB3; Pse1; RANBP5"
                     /coded_by="XM_047430296.1:301..3648"
                     /db_xref="GeneID:3843"
                     /db_xref="HGNC:HGNC:6402"
                     /db_xref="MIM:602008"
ORIGIN      
        1 mpedqvgkle atentisama aaaaeqqqfy lllgnllspd nvvrkqaeet yenipgqski
       61 tfllqairnt taaeearqma avllrrllss afdevypalp sdvqtaikse llmiiqmetq
      121 ssmrkkvcdi aaelarnlid edgnnqwpeg lkflfdsvss qnvglreaal hifwnfpgif
      181 gnqqqhyldv ikrmlvqcmq dqehpsirtl sarataafil anehnvalfk hfadllpgfl
      241 qavndscyqn ddsvlkslve iadtvpkylr phleatlqls lklcgdtsln nmqrqlalev
      301 ivtlsetaaa mlrkhtniva qtipqmlamm vdleededwa nadeledddf dsnavagesa
      361 ldrmacglgg klvlpmikeh imqmlqnpdw kyrhaglmal saigegchqq megilneivn
      421 fvllflqdph prvryaacna vgqmatdfap gfqkkfhekv iaallqtmed qgnqrvqaha
      481 aaalinfted cpksllipyl dnlvkhlhsi mvlklqeliq kgtklvleqv vtsiasvadt
      541 aeekfvpyyd lfmpslkhiv enavqkelrl lrgktiecis liglavgkek fmqdasdvmq
      601 lllktqtdfn dmedddpqis ymisawarmc kilgkefqqy lpvvmgplmk tasikpeval
      661 ldtqdmenms dddgwefvnl gdqqsfgikt agleekstac qmlvcyakel kegfveyteq
      721 vvklmvpllk fyfhdgvrva aaesmpllle carvrgpeyl tqmwhfmcda likaigtepd
      781 sdvlseimhs fakcievmgd gclnnehfee lggilkakle ehfknqelrq vkrqdedyde
      841 qveeslqded dndvyiltkv sdilhsifss ykekvlpwfe qllplivnli cphrpwpdrq
      901 wglcifddvi ehcspasfky aeyflrpmlq yvcdnspevr qaaayglgvm aqyggdnyrp
      961 fctealpllv rviqsadskt kenvnatenc isavgkimkf kpdcvnveev lphwlswlpl
     1021 hedkeeavqt fnylcdlies nhpivlgpnn tnlpkifsii aegemheaik hedpcakrla
     1081 nvvrqvqtsg glwteciaql speqqaaiqe llnsa
//
LOCUS       XP_047286253            1115 aa            linear   PRI 05-AUG-2025
DEFINITION  importin-5 isoform X1 [Homo sapiens].
ACCESSION   XP_047286253
VERSION     XP_047286253.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430297.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1115
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1115
                     /product="importin-5 isoform X1"
                     /calculated_mol_wt=125415
     Region          31..>652
                     /region_name="KAP95"
                     /note="Karyopherin (importin) beta [Intracellular
                     trafficking and secretion]; COG5215"
                     /db_xref="CDD:227540"
     Region          111..133
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          150..178
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          195..217
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          235..263
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          275..316
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          286..375
                     /region_name="Importin_rep_4"
                     /note="Importin repeat; pfam18808"
                     /db_xref="CDD:408579"
     Site            order(355..356,359,362..363,394..395,398,401..402,405,
                     435..436,439,442..443,446,478..479,482,485..486,528..529,
                     532,535..536)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          373..405
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          417..447
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          459..486
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          500..537
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          549..582
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          783..892
                     /region_name="Importin_rep_6"
                     /note="Importin repeat 6; pfam18829"
                     /db_xref="CDD:465881"
     Region          883..908
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Site            order(900..901,904,907..908,941..942,945,948..949,954,
                     982..983,992,995..996,999,1025..1026,1029,1032..1033)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          921..954
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          937..984
                     /region_name="HEAT_EZ"
                     /note="HEAT-like repeat; pfam13513"
                     /db_xref="CDD:463906"
     Region          964..1000
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          1009..1033
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          1023..1069
                     /region_name="Importin_rep_5"
                     /note="Importin repeat; pfam18816"
                     /db_xref="CDD:465877"
     CDS             1..1115
                     /gene="IPO5"
                     /gene_synonym="IMB3; imp5; KPNB3; Pse1; RANBP5"
                     /coded_by="XM_047430297.1:235..3582"
                     /db_xref="GeneID:3843"
                     /db_xref="HGNC:HGNC:6402"
                     /db_xref="MIM:602008"
ORIGIN      
        1 mpedqvgkle atentisama aaaaeqqqfy lllgnllspd nvvrkqaeet yenipgqski
       61 tfllqairnt taaeearqma avllrrllss afdevypalp sdvqtaikse llmiiqmetq
      121 ssmrkkvcdi aaelarnlid edgnnqwpeg lkflfdsvss qnvglreaal hifwnfpgif
      181 gnqqqhyldv ikrmlvqcmq dqehpsirtl sarataafil anehnvalfk hfadllpgfl
      241 qavndscyqn ddsvlkslve iadtvpkylr phleatlqls lklcgdtsln nmqrqlalev
      301 ivtlsetaaa mlrkhtniva qtipqmlamm vdleededwa nadeledddf dsnavagesa
      361 ldrmacglgg klvlpmikeh imqmlqnpdw kyrhaglmal saigegchqq megilneivn
      421 fvllflqdph prvryaacna vgqmatdfap gfqkkfhekv iaallqtmed qgnqrvqaha
      481 aaalinfted cpksllipyl dnlvkhlhsi mvlklqeliq kgtklvleqv vtsiasvadt
      541 aeekfvpyyd lfmpslkhiv enavqkelrl lrgktiecis liglavgkek fmqdasdvmq
      601 lllktqtdfn dmedddpqis ymisawarmc kilgkefqqy lpvvmgplmk tasikpeval
      661 ldtqdmenms dddgwefvnl gdqqsfgikt agleekstac qmlvcyakel kegfveyteq
      721 vvklmvpllk fyfhdgvrva aaesmpllle carvrgpeyl tqmwhfmcda likaigtepd
      781 sdvlseimhs fakcievmgd gclnnehfee lggilkakle ehfknqelrq vkrqdedyde
      841 qveeslqded dndvyiltkv sdilhsifss ykekvlpwfe qllplivnli cphrpwpdrq
      901 wglcifddvi ehcspasfky aeyflrpmlq yvcdnspevr qaaayglgvm aqyggdnyrp
      961 fctealpllv rviqsadskt kenvnatenc isavgkimkf kpdcvnveev lphwlswlpl
     1021 hedkeeavqt fnylcdlies nhpivlgpnn tnlpkifsii aegemheaik hedpcakrla
     1081 nvvrqvqtsg glwteciaql speqqaaiqe llnsa
//
LOCUS       XP_047286254            1115 aa            linear   PRI 05-AUG-2025
DEFINITION  importin-5 isoform X1 [Homo sapiens].
ACCESSION   XP_047286254
VERSION     XP_047286254.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430298.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1115
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1115
                     /product="importin-5 isoform X1"
                     /calculated_mol_wt=125415
     Region          31..>652
                     /region_name="KAP95"
                     /note="Karyopherin (importin) beta [Intracellular
                     trafficking and secretion]; COG5215"
                     /db_xref="CDD:227540"
     Region          111..133
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          150..178
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          195..217
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          235..263
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          275..316
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          286..375
                     /region_name="Importin_rep_4"
                     /note="Importin repeat; pfam18808"
                     /db_xref="CDD:408579"
     Site            order(355..356,359,362..363,394..395,398,401..402,405,
                     435..436,439,442..443,446,478..479,482,485..486,528..529,
                     532,535..536)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          373..405
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          417..447
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          459..486
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          500..537
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          549..582
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          783..892
                     /region_name="Importin_rep_6"
                     /note="Importin repeat 6; pfam18829"
                     /db_xref="CDD:465881"
     Region          883..908
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Site            order(900..901,904,907..908,941..942,945,948..949,954,
                     982..983,992,995..996,999,1025..1026,1029,1032..1033)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          921..954
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          937..984
                     /region_name="HEAT_EZ"
                     /note="HEAT-like repeat; pfam13513"
                     /db_xref="CDD:463906"
     Region          964..1000
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          1009..1033
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          1023..1069
                     /region_name="Importin_rep_5"
                     /note="Importin repeat; pfam18816"
                     /db_xref="CDD:465877"
     CDS             1..1115
                     /gene="IPO5"
                     /gene_synonym="IMB3; imp5; KPNB3; Pse1; RANBP5"
                     /coded_by="XM_047430298.1:358..3705"
                     /db_xref="GeneID:3843"
                     /db_xref="HGNC:HGNC:6402"
                     /db_xref="MIM:602008"
ORIGIN      
        1 mpedqvgkle atentisama aaaaeqqqfy lllgnllspd nvvrkqaeet yenipgqski
       61 tfllqairnt taaeearqma avllrrllss afdevypalp sdvqtaikse llmiiqmetq
      121 ssmrkkvcdi aaelarnlid edgnnqwpeg lkflfdsvss qnvglreaal hifwnfpgif
      181 gnqqqhyldv ikrmlvqcmq dqehpsirtl sarataafil anehnvalfk hfadllpgfl
      241 qavndscyqn ddsvlkslve iadtvpkylr phleatlqls lklcgdtsln nmqrqlalev
      301 ivtlsetaaa mlrkhtniva qtipqmlamm vdleededwa nadeledddf dsnavagesa
      361 ldrmacglgg klvlpmikeh imqmlqnpdw kyrhaglmal saigegchqq megilneivn
      421 fvllflqdph prvryaacna vgqmatdfap gfqkkfhekv iaallqtmed qgnqrvqaha
      481 aaalinfted cpksllipyl dnlvkhlhsi mvlklqeliq kgtklvleqv vtsiasvadt
      541 aeekfvpyyd lfmpslkhiv enavqkelrl lrgktiecis liglavgkek fmqdasdvmq
      601 lllktqtdfn dmedddpqis ymisawarmc kilgkefqqy lpvvmgplmk tasikpeval
      661 ldtqdmenms dddgwefvnl gdqqsfgikt agleekstac qmlvcyakel kegfveyteq
      721 vvklmvpllk fyfhdgvrva aaesmpllle carvrgpeyl tqmwhfmcda likaigtepd
      781 sdvlseimhs fakcievmgd gclnnehfee lggilkakle ehfknqelrq vkrqdedyde
      841 qveeslqded dndvyiltkv sdilhsifss ykekvlpwfe qllplivnli cphrpwpdrq
      901 wglcifddvi ehcspasfky aeyflrpmlq yvcdnspevr qaaayglgvm aqyggdnyrp
      961 fctealpllv rviqsadskt kenvnatenc isavgkimkf kpdcvnveev lphwlswlpl
     1021 hedkeeavqt fnylcdlies nhpivlgpnn tnlpkifsii aegemheaik hedpcakrla
     1081 nvvrqvqtsg glwteciaql speqqaaiqe llnsa
//
LOCUS       XP_047286255            1097 aa            linear   PRI 05-AUG-2025
DEFINITION  importin-5 isoform X2 [Homo sapiens].
ACCESSION   XP_047286255
VERSION     XP_047286255.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430299.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1097
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1097
                     /product="importin-5 isoform X2"
                     /calculated_mol_wt=123499
     Region          13..>634
                     /region_name="KAP95"
                     /note="Karyopherin (importin) beta [Intracellular
                     trafficking and secretion]; COG5215"
                     /db_xref="CDD:227540"
     Region          93..115
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          132..160
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          177..199
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          217..245
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          257..298
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          268..357
                     /region_name="Importin_rep_4"
                     /note="Importin repeat; pfam18808"
                     /db_xref="CDD:408579"
     Site            order(337..338,341,344..345,376..377,380,383..384,387,
                     417..418,421,424..425,428,460..461,464,467..468,510..511,
                     514,517..518)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          355..387
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          399..429
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          441..468
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          482..519
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          531..564
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          765..874
                     /region_name="Importin_rep_6"
                     /note="Importin repeat 6; pfam18829"
                     /db_xref="CDD:465881"
     Region          865..890
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Site            order(882..883,886,889..890,923..924,927,930..931,936,
                     964..965,974,977..978,981,1007..1008,1011,1014..1015)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          903..936
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          919..966
                     /region_name="HEAT_EZ"
                     /note="HEAT-like repeat; pfam13513"
                     /db_xref="CDD:463906"
     Region          946..982
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          991..1015
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          1005..1051
                     /region_name="Importin_rep_5"
                     /note="Importin repeat; pfam18816"
                     /db_xref="CDD:465877"
     CDS             1..1097
                     /gene="IPO5"
                     /gene_synonym="IMB3; imp5; KPNB3; Pse1; RANBP5"
                     /coded_by="XM_047430299.1:399..3692"
                     /db_xref="GeneID:3843"
                     /db_xref="HGNC:HGNC:6402"
                     /db_xref="MIM:602008"
ORIGIN      
        1 maaaaaeqqq fylllgnlls pdnvvrkqae etyenipgqs kitfllqair nttaaeearq
       61 maavllrrll ssafdevypa lpsdvqtaik sellmiiqme tqssmrkkvc diaaelarnl
      121 idedgnnqwp eglkflfdsv ssqnvglrea alhifwnfpg ifgnqqqhyl dvikrmlvqc
      181 mqdqehpsir tlsarataaf ilanehnval fkhfadllpg flqavndscy qnddsvlksl
      241 veiadtvpky lrphleatlq lslklcgdts lnnmqrqlal evivtlseta aamlrkhtni
      301 vaqtipqmla mmvdleeded wanadeledd dfdsnavage saldrmacgl ggklvlpmik
      361 ehimqmlqnp dwkyrhaglm alsaigegch qqmegilnei vnfvllflqd phprvryaac
      421 navgqmatdf apgfqkkfhe kviaallqtm edqgnqrvqa haaaalinft edcpksllip
      481 yldnlvkhlh simvlklqel iqkgtklvle qvvtsiasva dtaeekfvpy ydlfmpslkh
      541 ivenavqkel rllrgktiec isliglavgk ekfmqdasdv mqlllktqtd fndmedddpq
      601 isymisawar mckilgkefq qylpvvmgpl mktasikpev alldtqdmen msdddgwefv
      661 nlgdqqsfgi ktagleekst acqmlvcyak elkegfveyt eqvvklmvpl lkfyfhdgvr
      721 vaaaesmpll lecarvrgpe yltqmwhfmc dalikaigte pdsdvlseim hsfakcievm
      781 gdgclnnehf eelggilkak leehfknqel rqvkrqdedy deqveeslqd eddndvyilt
      841 kvsdilhsif ssykekvlpw feqllplivn licphrpwpd rqwglcifdd viehcspasf
      901 kyaeyflrpm lqyvcdnspe vrqaaayglg vmaqyggdny rpfctealpl lvrviqsads
      961 ktkenvnate ncisavgkim kfkpdcvnve evlphwlswl plhedkeeav qtfnylcdli
     1021 esnhpivlgp nntnlpkifs iiaegemhea ikhedpcakr lanvvrqvqt sgglwtecia
     1081 qlspeqqaai qellnsa
//
LOCUS       XP_047286256            1097 aa            linear   PRI 05-AUG-2025
DEFINITION  importin-5 isoform X2 [Homo sapiens].
ACCESSION   XP_047286256
VERSION     XP_047286256.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430300.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1097
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1097
                     /product="importin-5 isoform X2"
                     /calculated_mol_wt=123499
     Region          13..>634
                     /region_name="KAP95"
                     /note="Karyopherin (importin) beta [Intracellular
                     trafficking and secretion]; COG5215"
                     /db_xref="CDD:227540"
     Region          93..115
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          132..160
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          177..199
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          217..245
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          257..298
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          268..357
                     /region_name="Importin_rep_4"
                     /note="Importin repeat; pfam18808"
                     /db_xref="CDD:408579"
     Site            order(337..338,341,344..345,376..377,380,383..384,387,
                     417..418,421,424..425,428,460..461,464,467..468,510..511,
                     514,517..518)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          355..387
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          399..429
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          441..468
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          482..519
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          531..564
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          765..874
                     /region_name="Importin_rep_6"
                     /note="Importin repeat 6; pfam18829"
                     /db_xref="CDD:465881"
     Region          865..890
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Site            order(882..883,886,889..890,923..924,927,930..931,936,
                     964..965,974,977..978,981,1007..1008,1011,1014..1015)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          903..936
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          919..966
                     /region_name="HEAT_EZ"
                     /note="HEAT-like repeat; pfam13513"
                     /db_xref="CDD:463906"
     Region          946..982
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          991..1015
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          1005..1051
                     /region_name="Importin_rep_5"
                     /note="Importin repeat; pfam18816"
                     /db_xref="CDD:465877"
     CDS             1..1097
                     /gene="IPO5"
                     /gene_synonym="IMB3; imp5; KPNB3; Pse1; RANBP5"
                     /coded_by="XM_047430300.1:23..3316"
                     /db_xref="GeneID:3843"
                     /db_xref="HGNC:HGNC:6402"
                     /db_xref="MIM:602008"
ORIGIN      
        1 maaaaaeqqq fylllgnlls pdnvvrkqae etyenipgqs kitfllqair nttaaeearq
       61 maavllrrll ssafdevypa lpsdvqtaik sellmiiqme tqssmrkkvc diaaelarnl
      121 idedgnnqwp eglkflfdsv ssqnvglrea alhifwnfpg ifgnqqqhyl dvikrmlvqc
      181 mqdqehpsir tlsarataaf ilanehnval fkhfadllpg flqavndscy qnddsvlksl
      241 veiadtvpky lrphleatlq lslklcgdts lnnmqrqlal evivtlseta aamlrkhtni
      301 vaqtipqmla mmvdleeded wanadeledd dfdsnavage saldrmacgl ggklvlpmik
      361 ehimqmlqnp dwkyrhaglm alsaigegch qqmegilnei vnfvllflqd phprvryaac
      421 navgqmatdf apgfqkkfhe kviaallqtm edqgnqrvqa haaaalinft edcpksllip
      481 yldnlvkhlh simvlklqel iqkgtklvle qvvtsiasva dtaeekfvpy ydlfmpslkh
      541 ivenavqkel rllrgktiec isliglavgk ekfmqdasdv mqlllktqtd fndmedddpq
      601 isymisawar mckilgkefq qylpvvmgpl mktasikpev alldtqdmen msdddgwefv
      661 nlgdqqsfgi ktagleekst acqmlvcyak elkegfveyt eqvvklmvpl lkfyfhdgvr
      721 vaaaesmpll lecarvrgpe yltqmwhfmc dalikaigte pdsdvlseim hsfakcievm
      781 gdgclnnehf eelggilkak leehfknqel rqvkrqdedy deqveeslqd eddndvyilt
      841 kvsdilhsif ssykekvlpw feqllplivn licphrpwpd rqwglcifdd viehcspasf
      901 kyaeyflrpm lqyvcdnspe vrqaaayglg vmaqyggdny rpfctealpl lvrviqsads
      961 ktkenvnate ncisavgkim kfkpdcvnve evlphwlswl plhedkeeav qtfnylcdli
     1021 esnhpivlgp nntnlpkifs iiaegemhea ikhedpcakr lanvvrqvqt sgglwtecia
     1081 qlspeqqaai qellnsa
//
LOCUS       XP_024305115             200 aa            linear   PRI 05-AUG-2025
DEFINITION  ras-like protein family member 11A isoform X1 [Homo sapiens].
ACCESSION   XP_024305115
VERSION     XP_024305115.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449347.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..200
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..200
                     /product="ras-like protein family member 11A isoform X1"
                     /calculated_mol_wt=22469
     Region          1..156
                     /region_name="RERG_RasL11_like"
                     /note="Ras-related and Estrogen-Regulated Growth inhibitor
                     (RERG) and Ras-like 11 (RasL11)-like families; cd04146"
                     /db_xref="CDD:206713"
     Site            order(14,16,22..23,36..37,39,41..42,137)
                     /site_type="other"
                     /note="putative GEF interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:206713"
     Site            order(15..18,21..23)
                     /site_type="other"
                     /note="Switch I region"
                     /db_xref="CDD:206713"
     Site            order(15..16,20..23)
                     /site_type="active"
                     /note="putative effector interaction site [active]"
                     /db_xref="CDD:206713"
     Site            17
                     /site_type="other"
                     /note="G2 box"
                     /db_xref="CDD:206713"
     Site            39..42
                     /site_type="other"
                     /note="G3 box"
                     /db_xref="CDD:206713"
     Site            order(41..42,55..66)
                     /site_type="other"
                     /note="Switch II region"
                     /db_xref="CDD:206713"
     Site            105..108
                     /site_type="other"
                     /note="G4 box"
                     /db_xref="CDD:206713"
     Site            135..137
                     /site_type="other"
                     /note="G5 box"
                     /db_xref="CDD:206713"
     CDS             1..200
                     /gene="RASL11A"
                     /coded_by="XM_024449347.2:22..624"
                     /db_xref="GeneID:387496"
                     /db_xref="HGNC:HGNC:23802"
                     /db_xref="MIM:612403"
ORIGIN      
        1 mivrfltkrf igdyepntgk lysrlvyveg dqlslqiqdt pggvqiqdsl pqvvdslskc
       61 vqwaegfllv ysitdydsyl sirplyqhir kvhpdskapv iivgnkgdll harqvqtqdg
      121 iqlanelgsl fleistseny edvcdvfqhl ckevskmhgl sgerrrasii prprspnmqd
      181 lkrrfkqals pkvkapsalg
//
LOCUS       XP_047286257             119 aa            linear   PRI 05-AUG-2025
DEFINITION  complement C1q and tumor necrosis factor-related protein 9B isoform
            X1 [Homo sapiens].
ACCESSION   XP_047286257
VERSION     XP_047286257.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430301.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..119
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..119
                     /product="complement C1q and tumor necrosis factor-related
                     protein 9B isoform X1"
                     /calculated_mol_wt=13624
     CDS             1..119
                     /gene="C1QTNF9B"
                     /gene_synonym="CTRP9B"
                     /coded_by="XM_047430301.1:130..489"
                     /db_xref="GeneID:387911"
                     /db_xref="HGNC:HGNC:34072"
                     /db_xref="MIM:614148"
ORIGIN      
        1 mvcleemdet errvtkamqe pskssiplss rvmeekqsee tsshlqhsdh vpspcrrrgt
       61 qsienqdvla argrmgrver reneeqmekl kqkaskecsg vfgqkrsknt ahqrclrel
//
LOCUS       XP_011535796             398 aa            linear   PRI 05-AUG-2025
DEFINITION  lysosome-associated membrane glycoprotein 1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_011535796
VERSION     XP_011535796.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537494.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..398
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..398
                     /product="lysosome-associated membrane glycoprotein 1
                     isoform X1"
                     /calculated_mol_wt=42756
     Region          202..346
                     /region_name="Lamp"
                     /note="Lysosome-associated membrane glycoprotein (Lamp);
                     pfam01299"
                     /db_xref="CDD:460152"
     Region          362..392
                     /region_name="TM_EGFR-like"
                     /note="Transmembrane domain of the Epidermal Growth Factor
                     Receptor family of Protein Tyrosine Kinases; cd12087"
                     /db_xref="CDD:213052"
     Site            order(363..364,367..368,370..372,374..375,378)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:213052"
     CDS             1..398
                     /gene="LAMP1"
                     /gene_synonym="CD107a; LAMPA; LGP120"
                     /coded_by="XM_011537494.3:166..1362"
                     /db_xref="GeneID:3916"
                     /db_xref="HGNC:HGNC:6499"
                     /db_xref="MIM:153330"
ORIGIN      
        1 mglmhcasaa mfmvkngngt acimanfsaa fsvnydtksg pknmtfdlps datvvlnrss
       61 cgkentsdps lviafgrght ltlnftrnat rysvqlmsfv ynlsdthlfp nasskeiktv
      121 esitdiradi dkkyrcvsgt qvhmnnvtvt lhdatiqayl snssfsrget rceqdrpspt
      181 tappappsps pspvpkspsv dkynvsgtng tcllasmglq lnltyerkdn ttvtrllnin
      241 pnktsasgsc gahlvtlelh segttvllfq fgmnasssrf flqgiqlnti lpdardpafk
      301 aangslralq atvgnsykcn aeehvrvtka fsvnifkvwv qafkveggqf gsveecllde
      361 nsmlipiavg galaglvliv liaylvgrkr shagyqti
//
LOCUS       XP_005266431             627 aa            linear   PRI 05-AUG-2025
DEFINITION  plastin-2 isoform X1 [Homo sapiens].
ACCESSION   XP_005266431
VERSION     XP_005266431.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266374.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..627
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..627
                     /product="plastin-2 isoform X1"
                     /calculated_mol_wt=70158
     Region          13..79
                     /region_name="EFh"
                     /note="EF-hand, calcium binding motif; A diverse
                     superfamily of calcium sensors and calcium signal
                     modulators; most examples in this alignment model have 2
                     active canonical EF hands. Ca2+ binding induces a
                     conformational change in the EF-hand motif, leading to...;
                     cd00051"
                     /db_xref="CDD:238008"
     Site            order(22,24,26,33,62,64,66,73)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238008"
     Region          98..242
                     /region_name="CH_PLS_rpt1"
                     /note="first calponin homology (CH) domain found in the
                     plastin family; cd21292"
                     /db_xref="CDD:409141"
     Site            order(122,126,189,191..192,195..196,198,207..215,220,
                     222..223,225..226,229..230,233)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409141"
     Region          251..375
                     /region_name="CH_PLS2_rpt2"
                     /note="second calponin homology (CH) domain found in
                     plastin-2; cd21327"
                     /db_xref="CDD:409176"
     Site            order(266,270,329,331..332,335..336,338,346..354,359,
                     361..362,364..365,368..369,372)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409176"
     Region          374..507
                     /region_name="CH_SF"
                     /note="calponin homology (CH) domain superfamily; cl00030"
                     /db_xref="CDD:469584"
     Site            order(400,455,457..458,461..462,464,478..482,487,489..490,
                     492..493,496..497,500)
                     /site_type="other"
                     /note="actin binding site [polypeptide binding]"
                     /db_xref="CDD:409180"
     Region          511..625
                     /region_name="CH_PLS2_rpt4"
                     /note="fourth calponin homology (CH) domain found in
                     plastin-2; cd21333"
                     /db_xref="CDD:409182"
     Site            order(517,521,578,580..581,584..585,587,595..603,608,
                     610..611,613..614,617..618,621)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409182"
     CDS             1..627
                     /gene="LCP1"
                     /gene_synonym="CP64; HEL-S-37; L-PLASTIN; LC64P; LPL;
                     PLS2"
                     /coded_by="XM_005266374.3:13740..15623"
                     /db_xref="GeneID:3936"
                     /db_xref="HGNC:HGNC:6528"
                     /db_xref="MIM:153430"
ORIGIN      
        1 margsvsdee mmelreafak vdtdgngyis fnelndlfka aclplpgyrv reitenlmat
       61 gdldqdgris fdefikifhg lkstdvaktf rkainkkegi caiggtseqs svgtqhsyse
      121 eekyafvnwi nkalendpdc rhvipmnpnt ndlfnavgdg ivlckminls vpdtiderti
      181 nkkkltpfti qenlnlalns asaigchvvn igaedlkegk pylvlgllwq vikiglfadi
      241 elsrnealia llregesled lmklspeell lrwanyhlen agcnkignfs tdikdskayy
      301 hlleqvapkg deegvpavvi dmsglrekdd iqraecmlqq aerlgcrqfv tatdvvrgnp
      361 klnlafianl fnrypalhkp enqdidwgal egetreertf rnwmnslgvn prvnhlysdl
      421 sdalvifqly ekikvpvdwn rvnkppypkl ggnmkklenc nyavelgknq akfslvgigg
      481 qdlnegnrtl tlaliwqlmr rytlnileei gggqkvnddi ivnwvnetlr eakksssiss
      541 fkdpkistsl pvldlidaiq pgsinydllk tenlnddekl nnakyaisma rkigarvyal
      601 pedlvevnpk mvmtvfaclm gkgmkrv
//
LOCUS       XP_047286259             627 aa            linear   PRI 05-AUG-2025
DEFINITION  plastin-2 isoform X1 [Homo sapiens].
ACCESSION   XP_047286259
VERSION     XP_047286259.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430303.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..627
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..627
                     /product="plastin-2 isoform X1"
                     /calculated_mol_wt=70158
     Region          13..79
                     /region_name="EFh"
                     /note="EF-hand, calcium binding motif; A diverse
                     superfamily of calcium sensors and calcium signal
                     modulators; most examples in this alignment model have 2
                     active canonical EF hands. Ca2+ binding induces a
                     conformational change in the EF-hand motif, leading to...;
                     cd00051"
                     /db_xref="CDD:238008"
     Site            order(22,24,26,33,62,64,66,73)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238008"
     Region          98..242
                     /region_name="CH_PLS_rpt1"
                     /note="first calponin homology (CH) domain found in the
                     plastin family; cd21292"
                     /db_xref="CDD:409141"
     Site            order(122,126,189,191..192,195..196,198,207..215,220,
                     222..223,225..226,229..230,233)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409141"
     Region          251..375
                     /region_name="CH_PLS2_rpt2"
                     /note="second calponin homology (CH) domain found in
                     plastin-2; cd21327"
                     /db_xref="CDD:409176"
     Site            order(266,270,329,331..332,335..336,338,346..354,359,
                     361..362,364..365,368..369,372)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409176"
     Region          374..507
                     /region_name="CH_SF"
                     /note="calponin homology (CH) domain superfamily; cl00030"
                     /db_xref="CDD:469584"
     Site            order(400,455,457..458,461..462,464,478..482,487,489..490,
                     492..493,496..497,500)
                     /site_type="other"
                     /note="actin binding site [polypeptide binding]"
                     /db_xref="CDD:409180"
     Region          511..625
                     /region_name="CH_PLS2_rpt4"
                     /note="fourth calponin homology (CH) domain found in
                     plastin-2; cd21333"
                     /db_xref="CDD:409182"
     Site            order(517,521,578,580..581,584..585,587,595..603,608,
                     610..611,613..614,617..618,621)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409182"
     CDS             1..627
                     /gene="LCP1"
                     /gene_synonym="CP64; HEL-S-37; L-PLASTIN; LC64P; LPL;
                     PLS2"
                     /coded_by="XM_047430303.1:147..2030"
                     /db_xref="GeneID:3936"
                     /db_xref="HGNC:HGNC:6528"
                     /db_xref="MIM:153430"
ORIGIN      
        1 margsvsdee mmelreafak vdtdgngyis fnelndlfka aclplpgyrv reitenlmat
       61 gdldqdgris fdefikifhg lkstdvaktf rkainkkegi caiggtseqs svgtqhsyse
      121 eekyafvnwi nkalendpdc rhvipmnpnt ndlfnavgdg ivlckminls vpdtiderti
      181 nkkkltpfti qenlnlalns asaigchvvn igaedlkegk pylvlgllwq vikiglfadi
      241 elsrnealia llregesled lmklspeell lrwanyhlen agcnkignfs tdikdskayy
      301 hlleqvapkg deegvpavvi dmsglrekdd iqraecmlqq aerlgcrqfv tatdvvrgnp
      361 klnlafianl fnrypalhkp enqdidwgal egetreertf rnwmnslgvn prvnhlysdl
      421 sdalvifqly ekikvpvdwn rvnkppypkl ggnmkklenc nyavelgknq akfslvgigg
      481 qdlnegnrtl tlaliwqlmr rytlnileei gggqkvnddi ivnwvnetlr eakksssiss
      541 fkdpkistsl pvldlidaiq pgsinydllk tenlnddekl nnakyaisma rkigarvyal
      601 pedlvevnpk mvmtvfaclm gkgmkrv
//
LOCUS       XP_047286260             482 aa            linear   PRI 05-AUG-2025
DEFINITION  plastin-2 isoform X2 [Homo sapiens].
ACCESSION   XP_047286260
VERSION     XP_047286260.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430304.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..482
                     /product="plastin-2 isoform X2"
                     /calculated_mol_wt=53929
     Region          <1..97
                     /region_name="CH_SF"
                     /note="calponin homology (CH) domain superfamily; cl00030"
                     /db_xref="CDD:469584"
     Site            order(44,46..47,50..51,53,66..70,75,77..78,80..81,84..85,
                     88)
                     /site_type="other"
                     /note="actin binding site [polypeptide binding]"
                     /db_xref="CDD:409031"
     Region          106..230
                     /region_name="CH_PLS2_rpt2"
                     /note="second calponin homology (CH) domain found in
                     plastin-2; cd21327"
                     /db_xref="CDD:409176"
     Site            order(121,125,184,186..187,190..191,193,201..209,214,
                     216..217,219..220,223..224,227)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409176"
     Region          229..362
                     /region_name="CH_SF"
                     /note="calponin homology (CH) domain superfamily; cl00030"
                     /db_xref="CDD:469584"
     Site            order(255,310,312..313,316..317,319,333..337,342,344..345,
                     347..348,351..352,355)
                     /site_type="other"
                     /note="actin binding site [polypeptide binding]"
                     /db_xref="CDD:409180"
     Region          366..480
                     /region_name="CH_PLS2_rpt4"
                     /note="fourth calponin homology (CH) domain found in
                     plastin-2; cd21333"
                     /db_xref="CDD:409182"
     Site            order(372,376,433,435..436,439..440,442,450..458,463,
                     465..466,468..469,472..473,476)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409182"
     CDS             1..482
                     /gene="LCP1"
                     /gene_synonym="CP64; HEL-S-37; L-PLASTIN; LC64P; LPL;
                     PLS2"
                     /coded_by="XM_047430304.1:302..1750"
                     /db_xref="GeneID:3936"
                     /db_xref="HGNC:HGNC:6528"
                     /db_xref="MIM:153430"
ORIGIN      
        1 mnpntndlfn avgdgivlck minlsvpdti dertinkkkl tpftiqenln lalnsasaig
       61 chvvnigaed lkegkpylvl gllwqvikig lfadielsrn ealiallreg esledlmkls
      121 peelllrwan yhlenagcnk ignfstdikd skayyhlleq vapkgdeegv pavvidmsgl
      181 rekddiqrae cmlqqaerlg crqfvtatdv vrgnpklnla fianlfnryp alhkpenqdi
      241 dwgalegetr eertfrnwmn slgvnprvnh lysdlsdalv ifqlyekikv pvdwnrvnkp
      301 pypklggnmk klencnyave lgknqakfsl vgiggqdlne gnrtltlali wqlmrrytln
      361 ileeigggqk vnddiivnwv netlreakks ssissfkdpk istslpvldl idaiqpgsin
      421 ydllktenln ddeklnnaky aismarkiga rvyalpedlv evnpkmvmtv faclmgkgmk
      481 rv
//
LOCUS       XP_047286261             357 aa            linear   PRI 05-AUG-2025
DEFINITION  plastin-2 isoform X3 [Homo sapiens].
ACCESSION   XP_047286261
VERSION     XP_047286261.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430305.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..357
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..357
                     /product="plastin-2 isoform X3"
                     /calculated_mol_wt=40002
     Region          13..79
                     /region_name="EFh"
                     /note="EF-hand, calcium binding motif; A diverse
                     superfamily of calcium sensors and calcium signal
                     modulators; most examples in this alignment model have 2
                     active canonical EF hands. Ca2+ binding induces a
                     conformational change in the EF-hand motif, leading to...;
                     cd00051"
                     /db_xref="CDD:238008"
     Site            order(22,24,26,33,62,64,66,73)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238008"
     Region          98..242
                     /region_name="CH_PLS_rpt1"
                     /note="first calponin homology (CH) domain found in the
                     plastin family; cd21292"
                     /db_xref="CDD:409141"
     Site            order(122,126,189,191..192,195..196,198,207..215,220,
                     222..223,225..226,229..230,233)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409141"
     Region          251..>302
                     /region_name="CH_SF"
                     /note="calponin homology (CH) domain superfamily; cl00030"
                     /db_xref="CDD:469584"
     CDS             1..357
                     /gene="LCP1"
                     /gene_synonym="CP64; HEL-S-37; L-PLASTIN; LC64P; LPL;
                     PLS2"
                     /coded_by="XM_047430305.1:92..1165"
                     /db_xref="GeneID:3936"
                     /db_xref="HGNC:HGNC:6528"
                     /db_xref="MIM:153430"
ORIGIN      
        1 margsvsdee mmelreafak vdtdgngyis fnelndlfka aclplpgyrv reitenlmat
       61 gdldqdgris fdefikifhg lkstdvaktf rkainkkegi caiggtseqs svgtqhsyse
      121 eekyafvnwi nkalendpdc rhvipmnpnt ndlfnavgdg ivlckminls vpdtiderti
      181 nkkkltpfti qenlnlalns asaigchvvn igaedlkegk pylvlgllwq vikiglfadi
      241 elsrnealia llregesled lmklspeell lrwanyhlen agcnkignfs tdikltdfys
      301 nikvyiyfpv ynlihvnklf fspkdnriis tslgcllcis clfycyapfk kkskcdm
//
LOCUS       XP_047286263            1493 aa            linear   PRI 05-AUG-2025
DEFINITION  LIM domain only protein 7 isoform X1 [Homo sapiens].
ACCESSION   XP_047286263
VERSION     XP_047286263.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430307.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1493
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1493
                     /product="LIM domain only protein 7 isoform X1"
                     /calculated_mol_wt=170395
     Region          9..>71
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Region          423..570
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Site            order(835..836,839..843,852,855,887,891,894..895)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467153"
     Region          838..906
                     /region_name="PDZ"
                     /note="Domain present in PSD-95, Dlg, and ZO-1/2;
                     smart00228"
                     /db_xref="CDD:214570"
     Region          <1037..1093
                     /region_name="GBP_C"
                     /note="Guanylate-binding protein, C-terminal domain;
                     cd16269"
                     /db_xref="CDD:293879"
     Region          <1040..>1195
                     /region_name="DUF5401"
                     /note="Family of unknown function (DUF5401); pfam17380"
                     /db_xref="CDD:375164"
     Region          1080..1091
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:293879"
     Region          1424..1482
                     /region_name="LIM"
                     /note="LIM is a small protein-protein interaction domain,
                     containing two zinc fingers; cd08368"
                     /db_xref="CDD:259829"
     Site            order(1424,1427,1447,1450,1453,1456,1478,1481)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..1493
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /coded_by="XM_047430307.1:631..5112"
                     /db_xref="GeneID:4008"
                     /db_xref="HGNC:HGNC:6646"
                     /db_xref="MIM:604362"
ORIGIN      
        1 mqdynkddms yrrisavepk talpfnrflp nksrqpsyvp aplrkkkpdk hednrrswas
       61 pvyteadgtf ssnqrriwgt nvenwptvqg tsksscylee ekaktrsipn ivkddlyvrk
      121 lspvmpnpgn afdqflpkcw tpedvnwkri kretykpwyk efqgfsrrns dsededsgsd
      181 rsatvfsraq kaehrldgnc qrpslllela tkravkspds haarrsssas depsqflllq
      241 alqtysddil ssethtkidp tsgprlitrr knlsyapgyr rddlemaald pdlenddffv
      301 rktgafhanp yvlrafedfr kfseqddsve rdiilqcreg elvlpdlekd dmivrripaq
      361 kkevplsgap dryhpvpfpe pwtlppeiqa kflcvlertc pskeksnscr ilvpsyrqkk
      421 ddmltrkiqs wklgttvppi sftpgpcsea dlkrweaire asrlrhkkrl mverlfqkiy
      481 gengsksmsd vsaedvqnlr qlryeemqki ksqlkeqdqk wqddlakwkd rrksytsdlq
      541 kkkeereeie kqalekskrs sktfkemlqd resqnqkstv psrrrmysfd dvleegkrpp
      601 tmtvseasyq serveekgat ypseipkeds ttfakredrv tteiqlpsqs pveeqspasl
      661 sslrsrstqm estrvsaslp rsyrktdtvr ltsvvtprpf gsqtrgissl prsytmddaw
      721 kyngdvedik rtpnnvvstp apspdasqla sslssqkeva ateedvtrlp sptspfssls
      781 qdqaatskat lsstsgldlm sesgegeisp qrevsrsqdq fsdmrisinq tpgksldfgf
      841 tikwdipgif vasveagspa efsqlqvdde iiainntkfs yndskeweea makaqetghl
      901 vmdvrrygka dwgkdqpslp firhktlnlt smatkiigsp etkwidatsg iynsekssnl
      961 svttdfsesl qssnieskei ngihdesnaf eskasesisl knlkrrsqff eqgssdsvvp
     1021 dlpvptisap srwvwdqeee rkrqerwqke qdrllqekyq reqeklreew qrakqeaere
     1081 nskyldeelm vlssnsmslt trepslatwe atwsegskss dregtragee errqpqeevv
     1141 hedqgkkpqd qlviererkw eqqlqeeqeq krlqaeaeeq krpaeeqkrq aeieretsvr
     1201 iyqyrrpvds ydipkteeas sgflpgdrnk srsttelddy stnkngnnky ldqignmtss
     1261 qrrskkeqvp sgaelerqqi lqemrkrtpl hndnswirqr sasvnkepvs lpgimrrges
     1321 ldnldsprsn swrqppwlnq ptgfyasssv qdfsrpppql vstsnraymr npsssvppps
     1381 agsvktsttg vattqsptpr shspsasqsg sqlrnrsvsg kricsycnni lgkgaamiie
     1441 slglcyhlhc fkcvacecdl ggsssgaevr irnhqlycnd cylrfksgrp tam
//
LOCUS       XP_047286264            1488 aa            linear   PRI 05-AUG-2025
DEFINITION  LIM domain only protein 7 isoform X2 [Homo sapiens].
ACCESSION   XP_047286264
VERSION     XP_047286264.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430308.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1488
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1488
                     /product="LIM domain only protein 7 isoform X2"
                     /calculated_mol_wt=169669
     Region          9..>71
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Region          423..570
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Site            order(835..836,839..843,852,855,887,891,894..895)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467153"
     Region          838..906
                     /region_name="PDZ"
                     /note="Domain present in PSD-95, Dlg, and ZO-1/2;
                     smart00228"
                     /db_xref="CDD:214570"
     Region          <1032..1088
                     /region_name="GBP_C"
                     /note="Guanylate-binding protein, C-terminal domain;
                     cd16269"
                     /db_xref="CDD:293879"
     Region          <1035..>1316
                     /region_name="DUF5401"
                     /note="Family of unknown function (DUF5401); pfam17380"
                     /db_xref="CDD:375164"
     Region          1075..1086
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:293879"
     Region          1419..1477
                     /region_name="LIM"
                     /note="LIM is a small protein-protein interaction domain,
                     containing two zinc fingers; cd08368"
                     /db_xref="CDD:259829"
     Site            order(1419,1422,1442,1445,1448,1451,1473,1476)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..1488
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /coded_by="XM_047430308.1:631..5097"
                     /db_xref="GeneID:4008"
                     /db_xref="HGNC:HGNC:6646"
                     /db_xref="MIM:604362"
ORIGIN      
        1 mqdynkddms yrrisavepk talpfnrflp nksrqpsyvp aplrkkkpdk hednrrswas
       61 pvyteadgtf ssnqrriwgt nvenwptvqg tsksscylee ekaktrsipn ivkddlyvrk
      121 lspvmpnpgn afdqflpkcw tpedvnwkri kretykpwyk efqgfsrrns dsededsgsd
      181 rsatvfsraq kaehrldgnc qrpslllela tkravkspds haarrsssas depsqflllq
      241 alqtysddil ssethtkidp tsgprlitrr knlsyapgyr rddlemaald pdlenddffv
      301 rktgafhanp yvlrafedfr kfseqddsve rdiilqcreg elvlpdlekd dmivrripaq
      361 kkevplsgap dryhpvpfpe pwtlppeiqa kflcvlertc pskeksnscr ilvpsyrqkk
      421 ddmltrkiqs wklgttvppi sftpgpcsea dlkrweaire asrlrhkkrl mverlfqkiy
      481 gengsksmsd vsaedvqnlr qlryeemqki ksqlkeqdqk wqddlakwkd rrksytsdlq
      541 kkkeereeie kqalekskrs sktfkemlqd resqnqkstv psrrrmysfd dvleegkrpp
      601 tmtvseasyq serveekgat ypseipkeds ttfakredrv tteiqlpsqs pveeqspasl
      661 sslrsrstqm estrvsaslp rsyrktdtvr ltsvvtprpf gsqtrgissl prsytmddaw
      721 kyngdvedik rtpnnvvstp apspdasqla sslssqkeva ateedvtrlp sptspfssls
      781 qdqaatskat lsstsgldlm sesgegeisp qrevsrsqdq fsdmrisinq tpgksldfgf
      841 tikwdipgif vasveagspa efsqlqvdde iiainntkfs yndskeweea makaqetghl
      901 vmdvrrygka dwgkdqpslp firhktlnlt smatkiigsp etkwidatsg iynsekssnl
      961 svttdfsesl qssnieskei ngihdesnaf eskgssgfsy sswvylcgss dsvvpdlpvp
     1021 tisapsrwvw dqeeerkrqe rwqkeqdrll qekyqreqek lreewqrakq eaerenskyl
     1081 deelmvlssn smslttreps latweatwse gskssdregt rageeerrqp qeevvhedqg
     1141 kkpqdqlvie rerkweqqlq eeqeqkrlqa eaeeqkrpae eqkrqaeier etsvriyqyr
     1201 rpvdsydipk teeassgflp gdrnksrstt elddystnkn gnnkyldqig nmtssqrrsk
     1261 keqvpsgael erqqilqemr krtplhndns wirqrsasvn kepvslpgim rrgesldnld
     1321 sprsnswrqp pwlnqptgfy asssvqdfsr pppqlvstsn raymrnpsss vpppsagsvk
     1381 tsttgvattq sptprshsps asqsgsqlrn rsvsgkrics ycnnilgkga amiieslglc
     1441 yhlhcfkcva cecdlggsss gaevrirnhq lycndcylrf ksgrptam
//
LOCUS       XP_047286265            1480 aa            linear   PRI 05-AUG-2025
DEFINITION  LIM domain only protein 7 isoform X3 [Homo sapiens].
ACCESSION   XP_047286265
VERSION     XP_047286265.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430309.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1480
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1480
                     /product="LIM domain only protein 7 isoform X3"
                     /calculated_mol_wt=168826
     Region          9..>71
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Region          423..570
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Site            order(835..836,839..843,852,855,887,891,894..895)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467153"
     Region          838..906
                     /region_name="PDZ"
                     /note="Domain present in PSD-95, Dlg, and ZO-1/2;
                     smart00228"
                     /db_xref="CDD:214570"
     Region          <1024..1080
                     /region_name="GBP_C"
                     /note="Guanylate-binding protein, C-terminal domain;
                     cd16269"
                     /db_xref="CDD:293879"
     Region          <1027..>1308
                     /region_name="DUF5401"
                     /note="Family of unknown function (DUF5401); pfam17380"
                     /db_xref="CDD:375164"
     Region          1067..1078
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:293879"
     Region          1411..1469
                     /region_name="LIM"
                     /note="LIM is a small protein-protein interaction domain,
                     containing two zinc fingers; cd08368"
                     /db_xref="CDD:259829"
     Site            order(1411,1414,1434,1437,1440,1443,1465,1468)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..1480
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /coded_by="XM_047430309.1:631..5073"
                     /db_xref="GeneID:4008"
                     /db_xref="HGNC:HGNC:6646"
                     /db_xref="MIM:604362"
ORIGIN      
        1 mqdynkddms yrrisavepk talpfnrflp nksrqpsyvp aplrkkkpdk hednrrswas
       61 pvyteadgtf ssnqrriwgt nvenwptvqg tsksscylee ekaktrsipn ivkddlyvrk
      121 lspvmpnpgn afdqflpkcw tpedvnwkri kretykpwyk efqgfsrrns dsededsgsd
      181 rsatvfsraq kaehrldgnc qrpslllela tkravkspds haarrsssas depsqflllq
      241 alqtysddil ssethtkidp tsgprlitrr knlsyapgyr rddlemaald pdlenddffv
      301 rktgafhanp yvlrafedfr kfseqddsve rdiilqcreg elvlpdlekd dmivrripaq
      361 kkevplsgap dryhpvpfpe pwtlppeiqa kflcvlertc pskeksnscr ilvpsyrqkk
      421 ddmltrkiqs wklgttvppi sftpgpcsea dlkrweaire asrlrhkkrl mverlfqkiy
      481 gengsksmsd vsaedvqnlr qlryeemqki ksqlkeqdqk wqddlakwkd rrksytsdlq
      541 kkkeereeie kqalekskrs sktfkemlqd resqnqkstv psrrrmysfd dvleegkrpp
      601 tmtvseasyq serveekgat ypseipkeds ttfakredrv tteiqlpsqs pveeqspasl
      661 sslrsrstqm estrvsaslp rsyrktdtvr ltsvvtprpf gsqtrgissl prsytmddaw
      721 kyngdvedik rtpnnvvstp apspdasqla sslssqkeva ateedvtrlp sptspfssls
      781 qdqaatskat lsstsgldlm sesgegeisp qrevsrsqdq fsdmrisinq tpgksldfgf
      841 tikwdipgif vasveagspa efsqlqvdde iiainntkfs yndskeweea makaqetghl
      901 vmdvrrygka gspetkwida tsgiynseks snlsvttdfs eslqssnies keingihdes
      961 nafeskases islknlkrrs qffeqgssgf sysswvylcg ssdsvvpdlp vptisapsrw
     1021 vwdqeeerkr qerwqkeqdr llqekyqreq eklreewqra kqeaerensk yldeelmvls
     1081 snsmslttre pslatweatw segskssdre gtrageeerr qpqeevvhed qgkkpqdqlv
     1141 iererkweqq lqeeqeqkrl qaeaeeqkrp aeeqkrqaei eretsvriyq yrrpvdsydi
     1201 pkteeassgf lpgdrnksrs ttelddystn kngnnkyldq ignmtssqrr skkeqvpsga
     1261 elerqqilqe mrkrtplhnd nswirqrsas vnkepvslpg imrrgesldn ldsprsnswr
     1321 qppwlnqptg fyasssvqdf srpppqlvst snraymrnps ssvpppsags vktsttgvat
     1381 tqsptprshs psasqsgsql rnrsvsgkri csycnnilgk gaamiieslg lcyhlhcfkc
     1441 vacecdlggs ssgaevrirn hqlycndcyl rfksgrptam
//
LOCUS       XP_047286266            1474 aa            linear   PRI 05-AUG-2025
DEFINITION  LIM domain only protein 7 isoform X4 [Homo sapiens].
ACCESSION   XP_047286266
VERSION     XP_047286266.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430310.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1474
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1474
                     /product="LIM domain only protein 7 isoform X4"
                     /calculated_mol_wt=168145
     Region          9..>71
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Region          423..570
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Site            order(835..836,839..843,852,855,887,891,894..895)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467153"
     Region          838..906
                     /region_name="PDZ"
                     /note="Domain present in PSD-95, Dlg, and ZO-1/2;
                     smart00228"
                     /db_xref="CDD:214570"
     Region          <1018..1074
                     /region_name="GBP_C"
                     /note="Guanylate-binding protein, C-terminal domain;
                     cd16269"
                     /db_xref="CDD:293879"
     Region          <1021..>1176
                     /region_name="DUF5401"
                     /note="Family of unknown function (DUF5401); pfam17380"
                     /db_xref="CDD:375164"
     Region          1061..1072
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:293879"
     Region          1405..1463
                     /region_name="LIM"
                     /note="LIM is a small protein-protein interaction domain,
                     containing two zinc fingers; cd08368"
                     /db_xref="CDD:259829"
     Site            order(1405,1408,1428,1431,1434,1437,1459,1462)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..1474
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /coded_by="XM_047430310.1:631..5055"
                     /db_xref="GeneID:4008"
                     /db_xref="HGNC:HGNC:6646"
                     /db_xref="MIM:604362"
ORIGIN      
        1 mqdynkddms yrrisavepk talpfnrflp nksrqpsyvp aplrkkkpdk hednrrswas
       61 pvyteadgtf ssnqrriwgt nvenwptvqg tsksscylee ekaktrsipn ivkddlyvrk
      121 lspvmpnpgn afdqflpkcw tpedvnwkri kretykpwyk efqgfsrrns dsededsgsd
      181 rsatvfsraq kaehrldgnc qrpslllela tkravkspds haarrsssas depsqflllq
      241 alqtysddil ssethtkidp tsgprlitrr knlsyapgyr rddlemaald pdlenddffv
      301 rktgafhanp yvlrafedfr kfseqddsve rdiilqcreg elvlpdlekd dmivrripaq
      361 kkevplsgap dryhpvpfpe pwtlppeiqa kflcvlertc pskeksnscr ilvpsyrqkk
      421 ddmltrkiqs wklgttvppi sftpgpcsea dlkrweaire asrlrhkkrl mverlfqkiy
      481 gengsksmsd vsaedvqnlr qlryeemqki ksqlkeqdqk wqddlakwkd rrksytsdlq
      541 kkkeereeie kqalekskrs sktfkemlqd resqnqkstv psrrrmysfd dvleegkrpp
      601 tmtvseasyq serveekgat ypseipkeds ttfakredrv tteiqlpsqs pveeqspasl
      661 sslrsrstqm estrvsaslp rsyrktdtvr ltsvvtprpf gsqtrgissl prsytmddaw
      721 kyngdvedik rtpnnvvstp apspdasqla sslssqkeva ateedvtrlp sptspfssls
      781 qdqaatskat lsstsgldlm sesgegeisp qrevsrsqdq fsdmrisinq tpgksldfgf
      841 tikwdipgif vasveagspa efsqlqvdde iiainntkfs yndskeweea makaqetghl
      901 vmdvrrygka dwgkdqpslp firhktlnlt smatkiigsp etkwidatsg iynsekssnl
      961 svttdfsesl qssnieskei ngihdesnaf eskgssdsvv pdlpvptisa psrwvwdqee
     1021 erkrqerwqk eqdrllqeky qreqeklree wqrakqeaer enskyldeel mvlssnsmsl
     1081 ttrepslatw eatwsegsks sdregtrage eerrqpqeev vhedqgkkpq dqlviererk
     1141 weqqlqeeqe qkrlqaeaee qkrpaeeqkr qaeieretsv riyqyrrpvd sydipkteea
     1201 ssgflpgdrn ksrstteldd ystnkngnnk yldqignmts sqrrskkeqv psgaelerqq
     1261 ilqemrkrtp lhndnswirq rsasvnkepv slpgimrrge sldnldsprs nswrqppwln
     1321 qptgfyasss vqdfsrpppq lvstsnraym rnpsssvppp sagsvktstt gvattqsptp
     1381 rshspsasqs gsqlrnrsvs gkricsycnn ilgkgaamii eslglcyhlh cfkcvacecd
     1441 lggsssgaev rirnhqlycn dcylrfksgr ptam
//
LOCUS       XP_047286267            1466 aa            linear   PRI 05-AUG-2025
DEFINITION  LIM domain only protein 7 isoform X5 [Homo sapiens].
ACCESSION   XP_047286267
VERSION     XP_047286267.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430311.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1466
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1466
                     /product="LIM domain only protein 7 isoform X5"
                     /calculated_mol_wt=167302
     Region          9..>71
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Region          423..570
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Site            order(835..836,839..843,852,855,887,891,894..895)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467153"
     Region          838..906
                     /region_name="PDZ"
                     /note="Domain present in PSD-95, Dlg, and ZO-1/2;
                     smart00228"
                     /db_xref="CDD:214570"
     Region          <1010..1066
                     /region_name="GBP_C"
                     /note="Guanylate-binding protein, C-terminal domain;
                     cd16269"
                     /db_xref="CDD:293879"
     Region          <1013..>1168
                     /region_name="DUF5401"
                     /note="Family of unknown function (DUF5401); pfam17380"
                     /db_xref="CDD:375164"
     Region          1053..1064
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:293879"
     Region          1397..1455
                     /region_name="LIM"
                     /note="LIM is a small protein-protein interaction domain,
                     containing two zinc fingers; cd08368"
                     /db_xref="CDD:259829"
     Site            order(1397,1400,1420,1423,1426,1429,1451,1454)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..1466
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /coded_by="XM_047430311.1:631..5031"
                     /db_xref="GeneID:4008"
                     /db_xref="HGNC:HGNC:6646"
                     /db_xref="MIM:604362"
ORIGIN      
        1 mqdynkddms yrrisavepk talpfnrflp nksrqpsyvp aplrkkkpdk hednrrswas
       61 pvyteadgtf ssnqrriwgt nvenwptvqg tsksscylee ekaktrsipn ivkddlyvrk
      121 lspvmpnpgn afdqflpkcw tpedvnwkri kretykpwyk efqgfsrrns dsededsgsd
      181 rsatvfsraq kaehrldgnc qrpslllela tkravkspds haarrsssas depsqflllq
      241 alqtysddil ssethtkidp tsgprlitrr knlsyapgyr rddlemaald pdlenddffv
      301 rktgafhanp yvlrafedfr kfseqddsve rdiilqcreg elvlpdlekd dmivrripaq
      361 kkevplsgap dryhpvpfpe pwtlppeiqa kflcvlertc pskeksnscr ilvpsyrqkk
      421 ddmltrkiqs wklgttvppi sftpgpcsea dlkrweaire asrlrhkkrl mverlfqkiy
      481 gengsksmsd vsaedvqnlr qlryeemqki ksqlkeqdqk wqddlakwkd rrksytsdlq
      541 kkkeereeie kqalekskrs sktfkemlqd resqnqkstv psrrrmysfd dvleegkrpp
      601 tmtvseasyq serveekgat ypseipkeds ttfakredrv tteiqlpsqs pveeqspasl
      661 sslrsrstqm estrvsaslp rsyrktdtvr ltsvvtprpf gsqtrgissl prsytmddaw
      721 kyngdvedik rtpnnvvstp apspdasqla sslssqkeva ateedvtrlp sptspfssls
      781 qdqaatskat lsstsgldlm sesgegeisp qrevsrsqdq fsdmrisinq tpgksldfgf
      841 tikwdipgif vasveagspa efsqlqvdde iiainntkfs yndskeweea makaqetghl
      901 vmdvrrygka gspetkwida tsgiynseks snlsvttdfs eslqssnies keingihdes
      961 nafeskases islknlkrrs qffeqgssds vvpdlpvpti sapsrwvwdq eeerkrqerw
     1021 qkeqdrllqe kyqreqeklr eewqrakqea erenskylde elmvlssnsm slttrepsla
     1081 tweatwsegs kssdregtra geeerrqpqe evvhedqgkk pqdqlviere rkweqqlqee
     1141 qeqkrlqaea eeqkrpaeeq krqaeieret svriyqyrrp vdsydipkte eassgflpgd
     1201 rnksrsttel ddystnkngn nkyldqignm tssqrrskke qvpsgaeler qqilqemrkr
     1261 tplhndnswi rqrsasvnke pvslpgimrr gesldnldsp rsnswrqppw lnqptgfyas
     1321 ssvqdfsrpp pqlvstsnra ymrnpsssvp ppsagsvkts ttgvattqsp tprshspsas
     1381 qsgsqlrnrs vsgkricsyc nnilgkgaam iieslglcyh lhcfkcvace cdlggsssga
     1441 evrirnhqly cndcylrfks grptam
//
LOCUS       XP_047286268            1447 aa            linear   PRI 05-AUG-2025
DEFINITION  LIM domain only protein 7 isoform X6 [Homo sapiens].
ACCESSION   XP_047286268
VERSION     XP_047286268.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430312.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1447
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1447
                     /product="LIM domain only protein 7 isoform X6"
                     /calculated_mol_wt=165051
     Region          9..>71
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Region          423..570
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Site            order(835..836,839..843,852,855,887,891,894..895)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467153"
     Region          838..906
                     /region_name="PDZ"
                     /note="Domain present in PSD-95, Dlg, and ZO-1/2;
                     smart00228"
                     /db_xref="CDD:214570"
     Region          <991..1047
                     /region_name="GBP_C"
                     /note="Guanylate-binding protein, C-terminal domain;
                     cd16269"
                     /db_xref="CDD:293879"
     Region          <994..>1149
                     /region_name="DUF5401"
                     /note="Family of unknown function (DUF5401); pfam17380"
                     /db_xref="CDD:375164"
     Region          1034..1045
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:293879"
     Region          1378..1436
                     /region_name="LIM"
                     /note="LIM is a small protein-protein interaction domain,
                     containing two zinc fingers; cd08368"
                     /db_xref="CDD:259829"
     Site            order(1378,1381,1401,1404,1407,1410,1432,1435)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..1447
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /coded_by="XM_047430312.1:631..4974"
                     /db_xref="GeneID:4008"
                     /db_xref="HGNC:HGNC:6646"
                     /db_xref="MIM:604362"
ORIGIN      
        1 mqdynkddms yrrisavepk talpfnrflp nksrqpsyvp aplrkkkpdk hednrrswas
       61 pvyteadgtf ssnqrriwgt nvenwptvqg tsksscylee ekaktrsipn ivkddlyvrk
      121 lspvmpnpgn afdqflpkcw tpedvnwkri kretykpwyk efqgfsrrns dsededsgsd
      181 rsatvfsraq kaehrldgnc qrpslllela tkravkspds haarrsssas depsqflllq
      241 alqtysddil ssethtkidp tsgprlitrr knlsyapgyr rddlemaald pdlenddffv
      301 rktgafhanp yvlrafedfr kfseqddsve rdiilqcreg elvlpdlekd dmivrripaq
      361 kkevplsgap dryhpvpfpe pwtlppeiqa kflcvlertc pskeksnscr ilvpsyrqkk
      421 ddmltrkiqs wklgttvppi sftpgpcsea dlkrweaire asrlrhkkrl mverlfqkiy
      481 gengsksmsd vsaedvqnlr qlryeemqki ksqlkeqdqk wqddlakwkd rrksytsdlq
      541 kkkeereeie kqalekskrs sktfkemlqd resqnqkstv psrrrmysfd dvleegkrpp
      601 tmtvseasyq serveekgat ypseipkeds ttfakredrv tteiqlpsqs pveeqspasl
      661 sslrsrstqm estrvsaslp rsyrktdtvr ltsvvtprpf gsqtrgissl prsytmddaw
      721 kyngdvedik rtpnnvvstp apspdasqla sslssqkeva ateedvtrlp sptspfssls
      781 qdqaatskat lsstsgldlm sesgegeisp qrevsrsqdq fsdmrisinq tpgksldfgf
      841 tikwdipgif vasveagspa efsqlqvdde iiainntkfs yndskeweea makaqetghl
      901 vmdvrrygka gspetkwida tsgiynseks snlsvttdfs eslqssnies keingihdes
      961 nafeskgssd svvpdlpvpt isapsrwvwd qeeerkrqer wqkeqdrllq ekyqreqekl
     1021 reewqrakqe aerenskyld eelmvlssns mslttrepsl atweatwseg skssdregtr
     1081 ageeerrqpq eevvhedqgk kpqdqlvier erkweqqlqe eqeqkrlqae aeeqkrpaee
     1141 qkrqaeiere tsvriyqyrr pvdsydipkt eeassgflpg drnksrstte lddystnkng
     1201 nnkyldqign mtssqrrskk eqvpsgaele rqqilqemrk rtplhndnsw irqrsasvnk
     1261 epvslpgimr rgesldnlds prsnswrqpp wlnqptgfya sssvqdfsrp ppqlvstsnr
     1321 aymrnpsssv pppsagsvkt sttgvattqs ptprshspsa sqsgsqlrnr svsgkricsy
     1381 cnnilgkgaa miieslglcy hlhcfkcvac ecdlggsssg aevrirnhql ycndcylrfk
     1441 sgrptam
//
LOCUS       XP_047286270            1711 aa            linear   PRI 05-AUG-2025
DEFINITION  LIM domain only protein 7 isoform X7 [Homo sapiens].
ACCESSION   XP_047286270
VERSION     XP_047286270.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430314.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1711
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1711
                     /product="LIM domain only protein 7 isoform X7"
                     /calculated_mol_wt=195449
     Region          <42..100
                     /region_name="CH_SF"
                     /note="calponin homology (CH) domain superfamily; cl00030"
                     /db_xref="CDD:469584"
     Site            order(42,45..46,48,62..66,84,86..87,89..90,93..94,97)
                     /site_type="other"
                     /note="actin binding site [polypeptide binding]"
                     /db_xref="CDD:409031"
     Region          213..>275
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Region          627..774
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Site            order(1039..1040,1043..1047,1056,1059,1091,1095,
                     1098..1099)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467153"
     Region          1042..1110
                     /region_name="PDZ"
                     /note="Domain present in PSD-95, Dlg, and ZO-1/2;
                     smart00228"
                     /db_xref="CDD:214570"
     Region          <1258..>1506
                     /region_name="DUF5401"
                     /note="Family of unknown function (DUF5401); pfam17380"
                     /db_xref="CDD:375164"
     Region          1642..1700
                     /region_name="LIM"
                     /note="LIM is a small protein-protein interaction domain,
                     containing two zinc fingers; cd08368"
                     /db_xref="CDD:259829"
     Site            order(1642,1645,1665,1668,1671,1674,1696,1699)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..1711
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /coded_by="XM_047430314.1:14..5149"
                     /db_xref="GeneID:4008"
                     /db_xref="HGNC:HGNC:6646"
                     /db_xref="MIM:604362"
ORIGIN      
        1 mpghkiarlc mlwrterlyk pyvfffkyty awvlllplll tdninvflka ceqiglkeaq
       61 lfhpgdlqdl snrvtvkqee tdrrvknvli tlywlgrkaq snpyyngphl nlkafenllg
      121 qaltkaleds sflkrsgrds gygdiwcper geflapprhh kredsfesld slgsrsltsc
      181 ssditlrggr egfesdtdse ftfkmqdynk ddmsyrrisa vepktalpfn rflpnksrqp
      241 syvpaplrkk kpdkhednrr swaspvytea dgtfssnqrr iwgtnvenwp tvqgtskssc
      301 yleeekaktr sipnivkddl yvrklspvmp npgnafdqfl pkcwtpedvn wkrikretyk
      361 pwykefqgfs rrnsdseded sgsdrsatvf sraqkaehrl dgncqrpsll lelatkravk
      421 spdshaarrs ssasdepsqf lllqalqtys ddilssetht kidptsgprl itrrknlsya
      481 pgyrrddlem aaldpdlend dffvrktgaf hanpyvlraf edfrkfseqd dsverdiilq
      541 cregelvlpd lekddmivrr ipaqkkevpl sgapdryhpv pfpepwtlpp eiqakflcvl
      601 ertcpskeks nscrilvpsy rqkkddmltr kiqswklgtt vppisftpgp cseadlkrwe
      661 aireasrlrh kkrlmverlf qkiygengsk smsdvsaedv qnlrqlryee mqkiksqlke
      721 qdqkwqddla kwkdrrksyt sdlqkkkeer eeiekqalek skrssktfke mlqdresqnq
      781 kstvpsrrrm ysfddvleeg krpptmtvse asyqservee kgatypseip kedsttfakr
      841 edrvtteiql psqspveeqs paslsslrsr stqmestrvs aslprsyrkt dtvrltsvvt
      901 prpfgsqtrg isslprsytm ddawkyngdv edikrtpnnv vstpapspda sqlasslssq
      961 kevaateedv trlpsptspf sslsqdqaat skatlsstsg ldlmsesgeg eispqrevsr
     1021 sqdqfsdmri sinqtpgksl dfgftikwdi pgifvasvea gspaefsqlq vddeiiainn
     1081 tkfsyndske weeamakaqe tghlvmdvrr ygkadwgkdq pslpfirhkt lnltsmatki
     1141 igspetkwid atsgiynsek ssnlsvttdf seslqssnie skeingihde snafeskase
     1201 sislknlkrr sqffeqgssg fsysswvylc gssdsvvpdl pvptisapsr wvwdqeeerk
     1261 rqerwqkeqd rllqekyqre qeklreewqr akqeaerens kyldeelmvl ssnsmslttr
     1321 epslatweat wsegskssdr egtrageeer rqpqeevvhe dqgkkpqdql viererkweq
     1381 qlqeeqeqkr lqaeaeeqkr paeeqkrqae ieretsvriy qyrrpvdsyd ipkteeassg
     1441 flpgdrnksr sttelddyst nkngnnkyld qignmtssqr rskkeqvpsg aelerqqilq
     1501 emrkrtplhn dnswirqrsa svnkepvslp gimrrgesld nldsprsnsw rqppwlnqpt
     1561 gfyasssvqd fsrpppqlvs tsnraymrnp sssvpppsag svktsttgva ttqsptprsh
     1621 spsasqsgsq lrnrsvsgkr icsycnnilg kgaamiiesl glcyhlhcfk cvacecdlgg
     1681 sssgaevrir nhqlycndcy lrfksgrpta m
//
LOCUS       XP_047286271            1698 aa            linear   PRI 05-AUG-2025
DEFINITION  LIM domain only protein 7 isoform X8 [Homo sapiens].
ACCESSION   XP_047286271
VERSION     XP_047286271.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430315.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1698
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1698
                     /product="LIM domain only protein 7 isoform X8"
                     /calculated_mol_wt=193641
     Region          <29..87
                     /region_name="CH_SF"
                     /note="calponin homology (CH) domain superfamily; cl00030"
                     /db_xref="CDD:469584"
     Site            order(29,32..33,35,49..53,71,73..74,76..77,80..81,84)
                     /site_type="other"
                     /note="actin binding site [polypeptide binding]"
                     /db_xref="CDD:409031"
     Region          200..>262
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Region          614..761
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Site            order(1026..1027,1030..1034,1043,1046,1078,1082,
                     1085..1086)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467153"
     Region          1029..1097
                     /region_name="PDZ"
                     /note="Domain present in PSD-95, Dlg, and ZO-1/2;
                     smart00228"
                     /db_xref="CDD:214570"
     Region          <1245..>1493
                     /region_name="DUF5401"
                     /note="Family of unknown function (DUF5401); pfam17380"
                     /db_xref="CDD:375164"
     Region          1629..1687
                     /region_name="LIM"
                     /note="LIM is a small protein-protein interaction domain,
                     containing two zinc fingers; cd08368"
                     /db_xref="CDD:259829"
     Site            order(1629,1632,1652,1655,1658,1661,1683,1686)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..1698
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /coded_by="XM_047430315.1:27..5123"
                     /db_xref="GeneID:4008"
                     /db_xref="HGNC:HGNC:6646"
                     /db_xref="MIM:604362"
ORIGIN      
        1 mntrfllspi vwfpclsras sttkprfqdn invflkaceq iglkeaqlfh pgdlqdlsnr
       61 vtvkqeetdr rvknvlitly wlgrkaqsnp yyngphlnlk afenllgqal tkaledssfl
      121 krsgrdsgyg diwcpergef lapprhhkre dsfesldslg srsltscssd itlrggregf
      181 esdtdseftf kmqdynkddm syrrisavep ktalpfnrfl pnksrqpsyv paplrkkkpd
      241 khednrrswa spvyteadgt fssnqrriwg tnvenwptvq gtsksscyle eekaktrsip
      301 nivkddlyvr klspvmpnpg nafdqflpkc wtpedvnwkr ikretykpwy kefqgfsrrn
      361 sdsededsgs drsatvfsra qkaehrldgn cqrpslllel atkravkspd shaarrsssa
      421 sdepsqflll qalqtysddi lssethtkid ptsgprlitr rknlsyapgy rrddlemaal
      481 dpdlenddff vrktgafhan pyvlrafedf rkfseqddsv erdiilqcre gelvlpdlek
      541 ddmivrripa qkkevplsga pdryhpvpfp epwtlppeiq akflcvlert cpskeksnsc
      601 rilvpsyrqk kddmltrkiq swklgttvpp isftpgpcse adlkrweair easrlrhkkr
      661 lmverlfqki ygengsksms dvsaedvqnl rqlryeemqk iksqlkeqdq kwqddlakwk
      721 drrksytsdl qkkkeereei ekqalekskr ssktfkemlq dresqnqkst vpsrrrmysf
      781 ddvleegkrp ptmtvseasy qserveekga typseipked sttfakredr vtteiqlpsq
      841 spveeqspas lsslrsrstq mestrvsasl prsyrktdtv rltsvvtprp fgsqtrgiss
      901 lprsytmdda wkyngdvedi krtpnnvvst papspdasql asslssqkev aateedvtrl
      961 psptspfssl sqdqaatska tlsstsgldl msesgegeis pqrevsrsqd qfsdmrisin
     1021 qtpgksldfg ftikwdipgi fvasveagsp aefsqlqvdd eiiainntkf syndskewee
     1081 amakaqetgh lvmdvrrygk adwgkdqpsl pfirhktlnl tsmatkiigs petkwidats
     1141 giynsekssn lsvttdfses lqssnieske ingihdesna feskasesis lknlkrrsqf
     1201 feqgssgfsy sswvylcgss dsvvpdlpvp tisapsrwvw dqeeerkrqe rwqkeqdrll
     1261 qekyqreqek lreewqrakq eaerenskyl deelmvlssn smslttreps latweatwse
     1321 gskssdregt rageeerrqp qeevvhedqg kkpqdqlvie rerkweqqlq eeqeqkrlqa
     1381 eaeeqkrpae eqkrqaeier etsvriyqyr rpvdsydipk teeassgflp gdrnksrstt
     1441 elddystnkn gnnkyldqig nmtssqrrsk keqvpsgael erqqilqemr krtplhndns
     1501 wirqrsasvn kepvslpgim rrgesldnld sprsnswrqp pwlnqptgfy asssvqdfsr
     1561 pppqlvstsn raymrnpsss vpppsagsvk tsttgvattq sptprshsps asqsgsqlrn
     1621 rsvsgkrics ycnnilgkga amiieslglc yhlhcfkcva cecdlggsss gaevrirnhq
     1681 lycndcylrf ksgrptam
//
LOCUS       XP_047286272            1412 aa            linear   PRI 05-AUG-2025
DEFINITION  LIM domain only protein 7 isoform X9 [Homo sapiens].
ACCESSION   XP_047286272
VERSION     XP_047286272.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430316.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1412
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1412
                     /product="LIM domain only protein 7 isoform X9"
                     /calculated_mol_wt=161416
     Region          9..>71
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Region          355..502
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Site            order(767..768,771..775,784,787,819,823,826..827)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467153"
     Region          770..838
                     /region_name="PDZ"
                     /note="Domain present in PSD-95, Dlg, and ZO-1/2;
                     smart00228"
                     /db_xref="CDD:214570"
     Region          <956..1012
                     /region_name="GBP_C"
                     /note="Guanylate-binding protein, C-terminal domain;
                     cd16269"
                     /db_xref="CDD:293879"
     Region          <959..>1240
                     /region_name="DUF5401"
                     /note="Family of unknown function (DUF5401); pfam17380"
                     /db_xref="CDD:375164"
     Region          999..1010
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:293879"
     Region          1343..1401
                     /region_name="LIM"
                     /note="LIM is a small protein-protein interaction domain,
                     containing two zinc fingers; cd08368"
                     /db_xref="CDD:259829"
     Site            order(1343,1346,1366,1369,1372,1375,1397,1400)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..1412
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /coded_by="XM_047430316.1:631..4869"
                     /db_xref="GeneID:4008"
                     /db_xref="HGNC:HGNC:6646"
                     /db_xref="MIM:604362"
ORIGIN      
        1 mqdynkddms yrrisavepk talpfnrflp nksrqpsyvp aplrkkkpdk hednrrswas
       61 pvyteadgtf ssnqrriwgt nvenwptvqg tsksscylee ekaktrsipn ivkddlyvrk
      121 lspvmpnpgn afdqflpkcw tpedvnwkri kretykpwyk efqgfsqfll lqalqtysdd
      181 ilssethtki dptsgprlit rrknlsyapg yrrddlemaa ldpdlenddf fvrktgafha
      241 npyvlrafed frkfseqdds verdiilqcr egelvlpdle kddmivrrip aqkkevplsg
      301 apdryhpvpf pepwtlppei qakflcvler tcpskeksns crilvpsyrq kkddmltrki
      361 qswklgttvp pisftpgpcs eadlkrweai reasrlrhkk rlmverlfqk iygengsksm
      421 sdvsaedvqn lrqlryeemq kiksqlkeqd qkwqddlakw kdrrksytsd lqkkkeeree
      481 iekqaleksk rssktfkeml qdresqnqks tvpsrrrmys fddvleegkr pptmtvseas
      541 yqserveekg atypseipke dsttfakred rvtteiqlps qspveeqspa slsslrsrst
      601 qmestrvsas lprsyrktdt vrltsvvtpr pfgsqtrgis slprsytmdd awkyngdved
      661 ikrtpnnvvs tpapspdasq lasslssqke vaateedvtr lpsptspfss lsqdqaatsk
      721 atlsstsgld lmsesgegei spqrevsrsq dqfsdmrisi nqtpgksldf gftikwdipg
      781 ifvasveags paefsqlqvd deiiainntk fsyndskewe eamakaqetg hlvmdvrryg
      841 kagspetkwi datsgiynse kssnlsvttd fseslqssni eskeingihd esnafeskas
      901 esislknlkr rsqffeqgss gfsysswvyl cgssdsvvpd lpvptisaps rwvwdqeeer
      961 krqerwqkeq drllqekyqr eqeklreewq rakqeaeren skyldeelmv lssnsmsltt
     1021 repslatwea twsegskssd regtrageee rrqpqeevvh edqgkkpqdq lviererkwe
     1081 qqlqeeqeqk rlqaeaeeqk rpaeeqkrqa eieretsvri yqyrrpvdsy dipkteeass
     1141 gflpgdrnks rsttelddys tnkngnnkyl dqignmtssq rrskkeqvps gaelerqqil
     1201 qemrkrtplh ndnswirqrs asvnkepvsl pgimrrgesl dnldsprsns wrqppwlnqp
     1261 tgfyasssvq dfsrpppqlv stsnraymrn psssvpppsa gsvktsttgv attqsptprs
     1321 hspsasqsgs qlrnrsvsgk ricsycnnil gkgaamiies lglcyhlhcf kcvacecdlg
     1381 gsssgaevri rnhqlycndc ylrfksgrpt am
//
LOCUS       XP_047286273            1385 aa            linear   PRI 05-AUG-2025
DEFINITION  LIM domain only protein 7 isoform X10 [Homo sapiens].
ACCESSION   XP_047286273
VERSION     XP_047286273.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430317.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1385
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1385
                     /product="LIM domain only protein 7 isoform X10"
                     /calculated_mol_wt=158072
     Region          9..>71
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Region          355..502
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Site            order(767..768,771..775,784,787,819,823,826..827)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467153"
     Region          770..838
                     /region_name="PDZ"
                     /note="Domain present in PSD-95, Dlg, and ZO-1/2;
                     smart00228"
                     /db_xref="CDD:214570"
     Region          <942..998
                     /region_name="GBP_C"
                     /note="Guanylate-binding protein, C-terminal domain;
                     cd16269"
                     /db_xref="CDD:293879"
     Region          <945..>1100
                     /region_name="DUF5401"
                     /note="Family of unknown function (DUF5401); pfam17380"
                     /db_xref="CDD:375164"
     Region          985..996
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:293879"
     CDS             1..1385
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /coded_by="XM_047430317.1:631..4788"
                     /db_xref="GeneID:4008"
                     /db_xref="HGNC:HGNC:6646"
                     /db_xref="MIM:604362"
ORIGIN      
        1 mqdynkddms yrrisavepk talpfnrflp nksrqpsyvp aplrkkkpdk hednrrswas
       61 pvyteadgtf ssnqrriwgt nvenwptvqg tsksscylee ekaktrsipn ivkddlyvrk
      121 lspvmpnpgn afdqflpkcw tpedvnwkri kretykpwyk efqgfsqfll lqalqtysdd
      181 ilssethtki dptsgprlit rrknlsyapg yrrddlemaa ldpdlenddf fvrktgafha
      241 npyvlrafed frkfseqdds verdiilqcr egelvlpdle kddmivrrip aqkkevplsg
      301 apdryhpvpf pepwtlppei qakflcvler tcpskeksns crilvpsyrq kkddmltrki
      361 qswklgttvp pisftpgpcs eadlkrweai reasrlrhkk rlmverlfqk iygengsksm
      421 sdvsaedvqn lrqlryeemq kiksqlkeqd qkwqddlakw kdrrksytsd lqkkkeeree
      481 iekqaleksk rssktfkeml qdresqnqks tvpsrrrmys fddvleegkr pptmtvseas
      541 yqserveekg atypseipke dsttfakred rvtteiqlps qspveeqspa slsslrsrst
      601 qmestrvsas lprsyrktdt vrltsvvtpr pfgsqtrgis slprsytmdd awkyngdved
      661 ikrtpnnvvs tpapspdasq lasslssqke vaateedvtr lpsptspfss lsqdqaatsk
      721 atlsstsgld lmsesgegei spqrevsrsq dqfsdmrisi nqtpgksldf gftikwdipg
      781 ifvasveags paefsqlqvd deiiainntk fsyndskewe eamakaqetg hlvmdvrryg
      841 kagspetkwi datsgiynse kssnlsvttd fseslqssni eskeingihd esnafeskas
      901 esislknlkr rsqffeqgss dsvvpdlpvp tisapsrwvw dqeeerkrqe rwqkeqdrll
      961 qekyqreqek lreewqrakq eaerenskyl deelmvlssn smslttreps latweatwse
     1021 gskssdregt rageeerrqp qeevvhedqg kkpqdqlvie rerkweqqlq eeqeqkrlqa
     1081 eaeeqkrpae eqkrqaeier etsvriyqyr rpvdsydipk teeassgflp gdrnksrstt
     1141 elddystnkn gnnkyldqig nmtssqrrsk keqvpsgael erqqilqemr krtplhndns
     1201 wirqrsasvn kepvslpgim rrgesldnld sprsnswrqp pwlnqptgfy asssvqdfsr
     1261 pppqlvstsn raymrnpsss vpppsagsvk tsttgvattq sptprshsps asqsgsqlrn
     1321 svlpvsvtse alpqelksgs ettnctatta isdsnldgqp pcdvslhtka llqieeevva
     1381 ahvdl
//
LOCUS       XP_047286274            1643 aa            linear   PRI 05-AUG-2025
DEFINITION  LIM domain only protein 7 isoform X11 [Homo sapiens].
ACCESSION   XP_047286274
VERSION     XP_047286274.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430318.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1643
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1643
                     /product="LIM domain only protein 7 isoform X11"
                     /calculated_mol_wt=188039
     Region          <42..100
                     /region_name="CH_SF"
                     /note="calponin homology (CH) domain superfamily; cl00030"
                     /db_xref="CDD:469584"
     Site            order(42,45..46,48,62..66,84,86..87,89..90,93..94,97)
                     /site_type="other"
                     /note="actin binding site [polypeptide binding]"
                     /db_xref="CDD:409031"
     Region          213..>275
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Region          559..706
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Site            order(971..972,975..979,988,991,1023,1027,1030..1031)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467153"
     Region          974..1042
                     /region_name="PDZ"
                     /note="Domain present in PSD-95, Dlg, and ZO-1/2;
                     smart00228"
                     /db_xref="CDD:214570"
     Region          <1190..>1471
                     /region_name="DUF5401"
                     /note="Family of unknown function (DUF5401); pfam17380"
                     /db_xref="CDD:375164"
     Region          1574..1632
                     /region_name="LIM"
                     /note="LIM is a small protein-protein interaction domain,
                     containing two zinc fingers; cd08368"
                     /db_xref="CDD:259829"
     Site            order(1574,1577,1597,1600,1603,1606,1628,1631)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..1643
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /coded_by="XM_047430318.1:14..4945"
                     /db_xref="GeneID:4008"
                     /db_xref="HGNC:HGNC:6646"
                     /db_xref="MIM:604362"
ORIGIN      
        1 mpghkiarlc mlwrterlyk pyvfffkyty awvlllplll tdninvflka ceqiglkeaq
       61 lfhpgdlqdl snrvtvkqee tdrrvknvli tlywlgrkaq snpyyngphl nlkafenllg
      121 qaltkaleds sflkrsgrds gygdiwcper geflapprhh kredsfesld slgsrsltsc
      181 ssditlrggr egfesdtdse ftfkmqdynk ddmsyrrisa vepktalpfn rflpnksrqp
      241 syvpaplrkk kpdkhednrr swaspvytea dgtfssnqrr iwgtnvenwp tvqgtskssc
      301 yleeekaktr sipnivkddl yvrklspvmp npgnafdqfl pkcwtpedvn wkrikretyk
      361 pwykefqgfs qflllqalqt ysddilsset htkidptsgp rlitrrknls yapgyrrddl
      421 emaaldpdle nddffvrktg afhanpyvlr afedfrkfse qddsverdii lqcregelvl
      481 pdlekddmiv rripaqkkev plsgapdryh pvpfpepwtl ppeiqakflc vlertcpske
      541 ksnscrilvp syrqkkddml trkiqswklg ttvppisftp gpcseadlkr weaireasrl
      601 rhkkrlmver lfqkiygeng sksmsdvsae dvqnlrqlry eemqkiksql keqdqkwqdd
      661 lakwkdrrks ytsdlqkkke ereeiekqal ekskrssktf kemlqdresq nqkstvpsrr
      721 rmysfddvle egkrpptmtv seasyqserv eekgatypse ipkedsttfa kredrvttei
      781 qlpsqspvee qspaslsslr srstqmestr vsaslprsyr ktdtvrltsv vtprpfgsqt
      841 rgisslprsy tmddawkyng dvedikrtpn nvvstpapsp dasqlassls sqkevaatee
      901 dvtrlpspts pfsslsqdqa atskatlsst sgldlmsesg egeispqrev srsqdqfsdm
      961 risinqtpgk sldfgftikw dipgifvasv eagspaefsq lqvddeiiai nntkfsynds
     1021 keweeamaka qetghlvmdv rrygkadwgk dqpslpfirh ktlnltsmat kiigspetkw
     1081 idatsgiyns ekssnlsvtt dfseslqssn ieskeingih desnafeska sesislknlk
     1141 rrsqffeqgs sgfsysswvy lcgssdsvvp dlpvptisap srwvwdqeee rkrqerwqke
     1201 qdrllqekyq reqeklreew qrakqeaere nskyldeelm vlssnsmslt trepslatwe
     1261 atwsegskss dregtragee errqpqeevv hedqgkkpqd qlviererkw eqqlqeeqeq
     1321 krlqaeaeeq krpaeeqkrq aeieretsvr iyqyrrpvds ydipkteeas sgflpgdrnk
     1381 srsttelddy stnkngnnky ldqignmtss qrrskkeqvp sgaelerqqi lqemrkrtpl
     1441 hndnswirqr sasvnkepvs lpgimrrges ldnldsprsn swrqppwlnq ptgfyasssv
     1501 qdfsrpppql vstsnraymr npsssvppps agsvktsttg vattqsptpr shspsasqsg
     1561 sqlrnrsvsg kricsycnni lgkgaamiie slglcyhlhc fkcvacecdl ggsssgaevr
     1621 irnhqlycnd cylrfksgrp tam
//
LOCUS       XP_047286275            1630 aa            linear   PRI 05-AUG-2025
DEFINITION  LIM domain only protein 7 isoform X12 [Homo sapiens].
ACCESSION   XP_047286275
VERSION     XP_047286275.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430319.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1630
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1630
                     /product="LIM domain only protein 7 isoform X12"
                     /calculated_mol_wt=186231
     Region          <29..87
                     /region_name="CH_SF"
                     /note="calponin homology (CH) domain superfamily; cl00030"
                     /db_xref="CDD:469584"
     Site            order(29,32..33,35,49..53,71,73..74,76..77,80..81,84)
                     /site_type="other"
                     /note="actin binding site [polypeptide binding]"
                     /db_xref="CDD:409031"
     Region          200..>262
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Region          546..693
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Site            order(958..959,962..966,975,978,1010,1014,1017..1018)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467153"
     Region          961..1029
                     /region_name="PDZ"
                     /note="Domain present in PSD-95, Dlg, and ZO-1/2;
                     smart00228"
                     /db_xref="CDD:214570"
     Region          <1177..>1425
                     /region_name="DUF5401"
                     /note="Family of unknown function (DUF5401); pfam17380"
                     /db_xref="CDD:375164"
     Region          1561..1619
                     /region_name="LIM"
                     /note="LIM is a small protein-protein interaction domain,
                     containing two zinc fingers; cd08368"
                     /db_xref="CDD:259829"
     Site            order(1561,1564,1584,1587,1590,1593,1615,1618)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..1630
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /coded_by="XM_047430319.1:27..4919"
                     /db_xref="GeneID:4008"
                     /db_xref="HGNC:HGNC:6646"
                     /db_xref="MIM:604362"
ORIGIN      
        1 mntrfllspi vwfpclsras sttkprfqdn invflkaceq iglkeaqlfh pgdlqdlsnr
       61 vtvkqeetdr rvknvlitly wlgrkaqsnp yyngphlnlk afenllgqal tkaledssfl
      121 krsgrdsgyg diwcpergef lapprhhkre dsfesldslg srsltscssd itlrggregf
      181 esdtdseftf kmqdynkddm syrrisavep ktalpfnrfl pnksrqpsyv paplrkkkpd
      241 khednrrswa spvyteadgt fssnqrriwg tnvenwptvq gtsksscyle eekaktrsip
      301 nivkddlyvr klspvmpnpg nafdqflpkc wtpedvnwkr ikretykpwy kefqgfsqfl
      361 llqalqtysd dilssethtk idptsgprli trrknlsyap gyrrddlema aldpdlendd
      421 ffvrktgafh anpyvlrafe dfrkfseqdd sverdiilqc regelvlpdl ekddmivrri
      481 paqkkevpls gapdryhpvp fpepwtlppe iqakflcvle rtcpskeksn scrilvpsyr
      541 qkkddmltrk iqswklgttv ppisftpgpc seadlkrwea ireasrlrhk krlmverlfq
      601 kiygengsks msdvsaedvq nlrqlryeem qkiksqlkeq dqkwqddlak wkdrrksyts
      661 dlqkkkeere eiekqaleks krssktfkem lqdresqnqk stvpsrrrmy sfddvleegk
      721 rpptmtvsea syqserveek gatypseipk edsttfakre drvtteiqlp sqspveeqsp
      781 aslsslrsrs tqmestrvsa slprsyrktd tvrltsvvtp rpfgsqtrgi sslprsytmd
      841 dawkyngdve dikrtpnnvv stpapspdas qlasslssqk evaateedvt rlpsptspfs
      901 slsqdqaats katlsstsgl dlmsesgege ispqrevsrs qdqfsdmris inqtpgksld
      961 fgftikwdip gifvasveag spaefsqlqv ddeiiainnt kfsyndskew eeamakaqet
     1021 ghlvmdvrry gkadwgkdqp slpfirhktl nltsmatkii gspetkwida tsgiynseks
     1081 snlsvttdfs eslqssnies keingihdes nafeskases islknlkrrs qffeqgssgf
     1141 sysswvylcg ssdsvvpdlp vptisapsrw vwdqeeerkr qerwqkeqdr llqekyqreq
     1201 eklreewqra kqeaerensk yldeelmvls snsmslttre pslatweatw segskssdre
     1261 gtrageeerr qpqeevvhed qgkkpqdqlv iererkweqq lqeeqeqkrl qaeaeeqkrp
     1321 aeeqkrqaei eretsvriyq yrrpvdsydi pkteeassgf lpgdrnksrs ttelddystn
     1381 kngnnkyldq ignmtssqrr skkeqvpsga elerqqilqe mrkrtplhnd nswirqrsas
     1441 vnkepvslpg imrrgesldn ldsprsnswr qppwlnqptg fyasssvqdf srpppqlvst
     1501 snraymrnps ssvpppsags vktsttgvat tqsptprshs psasqsgsql rnrsvsgkri
     1561 csycnnilgk gaamiieslg lcyhlhcfkc vacecdlggs ssgaevrirn hqlycndcyl
     1621 rfksgrptam
//
LOCUS       XP_047286276            1345 aa            linear   PRI 05-AUG-2025
DEFINITION  LIM domain only protein 7 isoform X13 [Homo sapiens].
ACCESSION   XP_047286276
VERSION     XP_047286276.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430320.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1345
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1345
                     /product="LIM domain only protein 7 isoform X13"
                     /calculated_mol_wt=153329
     Region          9..>89
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Region          261..408
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Site            order(673..674,677..681,690,693,725,729,732..733)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467153"
     Region          676..744
                     /region_name="PDZ"
                     /note="Domain present in PSD-95, Dlg, and ZO-1/2;
                     smart00228"
                     /db_xref="CDD:214570"
     Region          <889..945
                     /region_name="GBP_C"
                     /note="Guanylate-binding protein, C-terminal domain;
                     cd16269"
                     /db_xref="CDD:293879"
     Region          <892..>1173
                     /region_name="DUF5401"
                     /note="Family of unknown function (DUF5401); pfam17380"
                     /db_xref="CDD:375164"
     Region          932..943
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:293879"
     Region          1276..1334
                     /region_name="LIM"
                     /note="LIM is a small protein-protein interaction domain,
                     containing two zinc fingers; cd08368"
                     /db_xref="CDD:259829"
     Site            order(1276,1279,1299,1302,1305,1308,1330,1333)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..1345
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /coded_by="XM_047430320.1:631..4668"
                     /db_xref="GeneID:4008"
                     /db_xref="HGNC:HGNC:6646"
                     /db_xref="MIM:604362"
ORIGIN      
        1 mqdynkddms yrrisavepk talpfnrflp nksrqpsyvp aplrkkkpdk hednrrswas
       61 pvyteadgtf ssqflllqal qtysddilss ethtkidpts gprlitrrkn lsyapgyrrd
      121 dlemaaldpd lenddffvrk tgafhanpyv lrafedfrkf seqddsverd iilqcregel
      181 vlpdlekddm ivrripaqkk evplsgapdr yhpvpfpepw tlppeiqakf lcvlertcps
      241 keksnscril vpsyrqkkdd mltrkiqswk lgttvppisf tpgpcseadl krweaireas
      301 rlrhkkrlmv erlfqkiyge ngsksmsdvs aedvqnlrql ryeemqkiks qlkeqdqkwq
      361 ddlakwkdrr ksytsdlqkk keereeiekq alekskrssk tfkemlqdre sqnqkstvps
      421 rrrmysfddv leegkrpptm tvseasyqse rveekgatyp seipkedstt fakredrvtt
      481 eiqlpsqspv eeqspaslss lrsrstqmes trvsaslprs yrktdtvrlt svvtprpfgs
      541 qtrgisslpr sytmddawky ngdvedikrt pnnvvstpap spdasqlass lssqkevaat
      601 eedvtrlpsp tspfsslsqd qaatskatls stsgldlmse sgegeispqr evsrsqdqfs
      661 dmrisinqtp gksldfgfti kwdipgifva sveagspaef sqlqvddeii ainntkfsyn
      721 dskeweeama kaqetghlvm dvrrygkadw gkdqpslpfi rhktlnltsm atkiigspet
      781 kwidatsgiy nsekssnlsv ttdfseslqs snieskeing ihdesnafes kasesislkn
      841 lkrrsqffeq gssgfsyssw vylcgssdsv vpdlpvptis apsrwvwdqe eerkrqerwq
      901 keqdrllqek yqreqeklre ewqrakqeae renskyldee lmvlssnsms lttrepslat
      961 weatwsegsk ssdregtrag eeerrqpqee vvhedqgkkp qdqlvierer kweqqlqeeq
     1021 eqkrlqaeae eqkrpaeeqk rqaeierets vriyqyrrpv dsydipktee assgflpgdr
     1081 nksrstteld dystnkngnn kyldqignmt ssqrrskkeq vpsgaelerq qilqemrkrt
     1141 plhndnswir qrsasvnkep vslpgimrrg esldnldspr snswrqppwl nqptgfyass
     1201 svqdfsrppp qlvstsnray mrnpsssvpp psagsvktst tgvattqspt prshspsasq
     1261 sgsqlrnrsv sgkricsycn nilgkgaami ieslglcyhl hcfkcvacec dlggsssgae
     1321 vrirnhqlyc ndcylrfksg rptam
//
LOCUS       XP_024305127            1318 aa            linear   PRI 05-AUG-2025
DEFINITION  LIM domain only protein 7 isoform X14 [Homo sapiens].
ACCESSION   XP_024305127
VERSION     XP_024305127.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449359.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1318
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1318
                     /product="LIM domain only protein 7 isoform X14"
                     /calculated_mol_wt=149985
     Region          9..>89
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Region          261..408
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Site            order(673..674,677..681,690,693,725,729,732..733)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467153"
     Region          676..744
                     /region_name="PDZ"
                     /note="Domain present in PSD-95, Dlg, and ZO-1/2;
                     smart00228"
                     /db_xref="CDD:214570"
     Region          <875..931
                     /region_name="GBP_C"
                     /note="Guanylate-binding protein, C-terminal domain;
                     cd16269"
                     /db_xref="CDD:293879"
     Region          <878..>1033
                     /region_name="DUF5401"
                     /note="Family of unknown function (DUF5401); pfam17380"
                     /db_xref="CDD:375164"
     Region          918..929
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:293879"
     CDS             1..1318
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /coded_by="XM_024449359.2:631..4587"
                     /db_xref="GeneID:4008"
                     /db_xref="HGNC:HGNC:6646"
                     /db_xref="MIM:604362"
ORIGIN      
        1 mqdynkddms yrrisavepk talpfnrflp nksrqpsyvp aplrkkkpdk hednrrswas
       61 pvyteadgtf ssqflllqal qtysddilss ethtkidpts gprlitrrkn lsyapgyrrd
      121 dlemaaldpd lenddffvrk tgafhanpyv lrafedfrkf seqddsverd iilqcregel
      181 vlpdlekddm ivrripaqkk evplsgapdr yhpvpfpepw tlppeiqakf lcvlertcps
      241 keksnscril vpsyrqkkdd mltrkiqswk lgttvppisf tpgpcseadl krweaireas
      301 rlrhkkrlmv erlfqkiyge ngsksmsdvs aedvqnlrql ryeemqkiks qlkeqdqkwq
      361 ddlakwkdrr ksytsdlqkk keereeiekq alekskrssk tfkemlqdre sqnqkstvps
      421 rrrmysfddv leegkrpptm tvseasyqse rveekgatyp seipkedstt fakredrvtt
      481 eiqlpsqspv eeqspaslss lrsrstqmes trvsaslprs yrktdtvrlt svvtprpfgs
      541 qtrgisslpr sytmddawky ngdvedikrt pnnvvstpap spdasqlass lssqkevaat
      601 eedvtrlpsp tspfsslsqd qaatskatls stsgldlmse sgegeispqr evsrsqdqfs
      661 dmrisinqtp gksldfgfti kwdipgifva sveagspaef sqlqvddeii ainntkfsyn
      721 dskeweeama kaqetghlvm dvrrygkadw gkdqpslpfi rhktlnltsm atkiigspet
      781 kwidatsgiy nsekssnlsv ttdfseslqs snieskeing ihdesnafes kasesislkn
      841 lkrrsqffeq gssdsvvpdl pvptisapsr wvwdqeeerk rqerwqkeqd rllqekyqre
      901 qeklreewqr akqeaerens kyldeelmvl ssnsmslttr epslatweat wsegskssdr
      961 egtrageeer rqpqeevvhe dqgkkpqdql viererkweq qlqeeqeqkr lqaeaeeqkr
     1021 paeeqkrqae ieretsvriy qyrrpvdsyd ipkteeassg flpgdrnksr sttelddyst
     1081 nkngnnkyld qignmtssqr rskkeqvpsg aelerqqilq emrkrtplhn dnswirqrsa
     1141 svnkepvslp gimrrgesld nldsprsnsw rqppwlnqpt gfyasssvqd fsrpppqlvs
     1201 tsnraymrnp sssvpppsag svktsttgva ttqsptprsh spsasqsgsq lrnsvlpvsv
     1261 tsealpqelk sgsettncta ttaisdsnld gqppcdvslh tkallqieee vvaahvdl
//
LOCUS       XP_047286277            1318 aa            linear   PRI 05-AUG-2025
DEFINITION  LIM domain only protein 7 isoform X15 [Homo sapiens].
ACCESSION   XP_047286277
VERSION     XP_047286277.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430321.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1318
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1318
                     /product="LIM domain only protein 7 isoform X15"
                     /calculated_mol_wt=150236
     Region          9..>89
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Region          261..408
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Site            order(673..674,677..681,690,693,725,729,732..733)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467153"
     Region          676..744
                     /region_name="PDZ"
                     /note="Domain present in PSD-95, Dlg, and ZO-1/2;
                     smart00228"
                     /db_xref="CDD:214570"
     Region          <862..918
                     /region_name="GBP_C"
                     /note="Guanylate-binding protein, C-terminal domain;
                     cd16269"
                     /db_xref="CDD:293879"
     Region          <865..>1020
                     /region_name="DUF5401"
                     /note="Family of unknown function (DUF5401); pfam17380"
                     /db_xref="CDD:375164"
     Region          905..916
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:293879"
     Region          1249..1307
                     /region_name="LIM"
                     /note="LIM is a small protein-protein interaction domain,
                     containing two zinc fingers; cd08368"
                     /db_xref="CDD:259829"
     Site            order(1249,1252,1272,1275,1278,1281,1303,1306)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..1318
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /coded_by="XM_047430321.1:631..4587"
                     /db_xref="GeneID:4008"
                     /db_xref="HGNC:HGNC:6646"
                     /db_xref="MIM:604362"
ORIGIN      
        1 mqdynkddms yrrisavepk talpfnrflp nksrqpsyvp aplrkkkpdk hednrrswas
       61 pvyteadgtf ssqflllqal qtysddilss ethtkidpts gprlitrrkn lsyapgyrrd
      121 dlemaaldpd lenddffvrk tgafhanpyv lrafedfrkf seqddsverd iilqcregel
      181 vlpdlekddm ivrripaqkk evplsgapdr yhpvpfpepw tlppeiqakf lcvlertcps
      241 keksnscril vpsyrqkkdd mltrkiqswk lgttvppisf tpgpcseadl krweaireas
      301 rlrhkkrlmv erlfqkiyge ngsksmsdvs aedvqnlrql ryeemqkiks qlkeqdqkwq
      361 ddlakwkdrr ksytsdlqkk keereeiekq alekskrssk tfkemlqdre sqnqkstvps
      421 rrrmysfddv leegkrpptm tvseasyqse rveekgatyp seipkedstt fakredrvtt
      481 eiqlpsqspv eeqspaslss lrsrstqmes trvsaslprs yrktdtvrlt svvtprpfgs
      541 qtrgisslpr sytmddawky ngdvedikrt pnnvvstpap spdasqlass lssqkevaat
      601 eedvtrlpsp tspfsslsqd qaatskatls stsgldlmse sgegeispqr evsrsqdqfs
      661 dmrisinqtp gksldfgfti kwdipgifva sveagspaef sqlqvddeii ainntkfsyn
      721 dskeweeama kaqetghlvm dvrrygkags petkwidats giynsekssn lsvttdfses
      781 lqssnieske ingihdesna feskasesis lknlkrrsqf feqgssgfsy sswvylcgss
      841 dsvvpdlpvp tisapsrwvw dqeeerkrqe rwqkeqdrll qekyqreqek lreewqrakq
      901 eaerenskyl deelmvlssn smslttreps latweatwse gskssdregt rageeerrqp
      961 qeevvhedqg kkpqdqlvie rerkweqqlq eeqeqkrlqa eaeeqkrpae eqkrqaeier
     1021 etsvriyqyr rpvdsydipk teeassgflp gdrnksrstt elddystnkn gnnkyldqig
     1081 nmtssqrrsk keqvpsgael erqqilqemr krtplhndns wirqrsasvn kepvslpgim
     1141 rrgesldnld sprsnswrqp pwlnqptgfy asssvqdfsr pppqlvstsn raymrnpsss
     1201 vpppsagsvk tsttgvattq sptprshsps asqsgsqlrn rsvsgkrics ycnnilgkga
     1261 amiieslglc yhlhcfkcva cecdlggsss gaevrirnhq lycndcylrf ksgrptam
//
LOCUS       XP_047286278            1304 aa            linear   PRI 05-AUG-2025
DEFINITION  LIM domain only protein 7 isoform X16 [Homo sapiens].
ACCESSION   XP_047286278
VERSION     XP_047286278.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430322.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1304
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1304
                     /product="LIM domain only protein 7 isoform X16"
                     /calculated_mol_wt=148711
     Region          9..>89
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Region          261..408
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Site            order(673..674,677..681,690,693,725,729,732..733)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467153"
     Region          676..744
                     /region_name="PDZ"
                     /note="Domain present in PSD-95, Dlg, and ZO-1/2;
                     smart00228"
                     /db_xref="CDD:214570"
     Region          <848..904
                     /region_name="GBP_C"
                     /note="Guanylate-binding protein, C-terminal domain;
                     cd16269"
                     /db_xref="CDD:293879"
     Region          <851..>1006
                     /region_name="DUF5401"
                     /note="Family of unknown function (DUF5401); pfam17380"
                     /db_xref="CDD:375164"
     Region          891..902
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:293879"
     Region          1235..1293
                     /region_name="LIM"
                     /note="LIM is a small protein-protein interaction domain,
                     containing two zinc fingers; cd08368"
                     /db_xref="CDD:259829"
     Site            order(1235,1238,1258,1261,1264,1267,1289,1292)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..1304
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /coded_by="XM_047430322.1:631..4545"
                     /db_xref="GeneID:4008"
                     /db_xref="HGNC:HGNC:6646"
                     /db_xref="MIM:604362"
ORIGIN      
        1 mqdynkddms yrrisavepk talpfnrflp nksrqpsyvp aplrkkkpdk hednrrswas
       61 pvyteadgtf ssqflllqal qtysddilss ethtkidpts gprlitrrkn lsyapgyrrd
      121 dlemaaldpd lenddffvrk tgafhanpyv lrafedfrkf seqddsverd iilqcregel
      181 vlpdlekddm ivrripaqkk evplsgapdr yhpvpfpepw tlppeiqakf lcvlertcps
      241 keksnscril vpsyrqkkdd mltrkiqswk lgttvppisf tpgpcseadl krweaireas
      301 rlrhkkrlmv erlfqkiyge ngsksmsdvs aedvqnlrql ryeemqkiks qlkeqdqkwq
      361 ddlakwkdrr ksytsdlqkk keereeiekq alekskrssk tfkemlqdre sqnqkstvps
      421 rrrmysfddv leegkrpptm tvseasyqse rveekgatyp seipkedstt fakredrvtt
      481 eiqlpsqspv eeqspaslss lrsrstqmes trvsaslprs yrktdtvrlt svvtprpfgs
      541 qtrgisslpr sytmddawky ngdvedikrt pnnvvstpap spdasqlass lssqkevaat
      601 eedvtrlpsp tspfsslsqd qaatskatls stsgldlmse sgegeispqr evsrsqdqfs
      661 dmrisinqtp gksldfgfti kwdipgifva sveagspaef sqlqvddeii ainntkfsyn
      721 dskeweeama kaqetghlvm dvrrygkags petkwidats giynsekssn lsvttdfses
      781 lqssnieske ingihdesna feskasesis lknlkrrsqf feqgssdsvv pdlpvptisa
      841 psrwvwdqee erkrqerwqk eqdrllqeky qreqeklree wqrakqeaer enskyldeel
      901 mvlssnsmsl ttrepslatw eatwsegsks sdregtrage eerrqpqeev vhedqgkkpq
      961 dqlviererk weqqlqeeqe qkrlqaeaee qkrpaeeqkr qaeieretsv riyqyrrpvd
     1021 sydipkteea ssgflpgdrn ksrstteldd ystnkngnnk yldqignmts sqrrskkeqv
     1081 psgaelerqq ilqemrkrtp lhndnswirq rsasvnkepv slpgimrrge sldnldsprs
     1141 nswrqppwln qptgfyasss vqdfsrpppq lvstsnraym rnpsssvppp sagsvktstt
     1201 gvattqsptp rshspsasqs gsqlrnrsvs gkricsycnn ilgkgaamii eslglcyhlh
     1261 cfkcvacecd lggsssgaev rirnhqlycn dcylrfksgr ptam
//
LOCUS       XP_047286279            1507 aa            linear   PRI 05-AUG-2025
DEFINITION  LIM domain only protein 7 isoform X17 [Homo sapiens].
ACCESSION   XP_047286279
VERSION     XP_047286279.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430323.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1507
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1507
                     /product="LIM domain only protein 7 isoform X17"
                     /calculated_mol_wt=171920
     Region          9..>71
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Region          423..570
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Site            order(835..836,839..843,852,855,887,891,894..895)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467153"
     Region          838..906
                     /region_name="PDZ"
                     /note="Domain present in PSD-95, Dlg, and ZO-1/2;
                     smart00228"
                     /db_xref="CDD:214570"
     Region          <1051..1107
                     /region_name="GBP_C"
                     /note="Guanylate-binding protein, C-terminal domain;
                     cd16269"
                     /db_xref="CDD:293879"
     Region          <1054..>1209
                     /region_name="DUF5401"
                     /note="Family of unknown function (DUF5401); pfam17380"
                     /db_xref="CDD:375164"
     Region          1094..1105
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:293879"
     Region          1438..1496
                     /region_name="LIM"
                     /note="LIM is a small protein-protein interaction domain,
                     containing two zinc fingers; cd08368"
                     /db_xref="CDD:259829"
     Site            order(1438,1441,1461,1464,1467,1470,1492,1495)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..1507
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /coded_by="XM_047430323.1:786..5309"
                     /db_xref="GeneID:4008"
                     /db_xref="HGNC:HGNC:6646"
                     /db_xref="MIM:604362"
ORIGIN      
        1 mqdynkddms yrrisavepk talpfnrflp nksrqpsyvp aplrkkkpdk hednrrswas
       61 pvyteadgtf ssnqrriwgt nvenwptvqg tsksscylee ekaktrsipn ivkddlyvrk
      121 lspvmpnpgn afdqflpkcw tpedvnwkri kretykpwyk efqgfsrrns dsededsgsd
      181 rsatvfsraq kaehrldgnc qrpslllela tkravkspds haarrsssas depsqflllq
      241 alqtysddil ssethtkidp tsgprlitrr knlsyapgyr rddlemaald pdlenddffv
      301 rktgafhanp yvlrafedfr kfseqddsve rdiilqcreg elvlpdlekd dmivrripaq
      361 kkevplsgap dryhpvpfpe pwtlppeiqa kflcvlertc pskeksnscr ilvpsyrqkk
      421 ddmltrkiqs wklgttvppi sftpgpcsea dlkrweaire asrlrhkkrl mverlfqkiy
      481 gengsksmsd vsaedvqnlr qlryeemqki ksqlkeqdqk wqddlakwkd rrksytsdlq
      541 kkkeereeie kqalekskrs sktfkemlqd resqnqkstv psrrrmysfd dvleegkrpp
      601 tmtvseasyq serveekgat ypseipkeds ttfakredrv tteiqlpsqs pveeqspasl
      661 sslrsrstqm estrvsaslp rsyrktdtvr ltsvvtprpf gsqtrgissl prsytmddaw
      721 kyngdvedik rtpnnvvstp apspdasqla sslssqkeva ateedvtrlp sptspfssls
      781 qdqaatskat lsstsgldlm sesgegeisp qrevsrsqdq fsdmrisinq tpgksldfgf
      841 tikwdipgif vasveagspa efsqlqvdde iiainntkfs yndskeweea makaqetghl
      901 vmdvrrygka dwgkdqpslp firhktlnlt smatkiigsp etkwidatsg iynsekssnl
      961 svttdfsesl qssnieskei ngihdesnaf eskasesisl knlkrrsqff eqgssgfsys
     1021 swvylcgssd svvpdlpvpt isapsrwvwd qeeerkrqer wqkeqdrllq ekyqreqekl
     1081 reewqrakqe aerenskyld eelmvlssns mslttrepsl atweatwseg skssdregtr
     1141 ageeerrqpq eevvhedqgk kpqdqlvier erkweqqlqe eqeqkrlqae aeeqkrpaee
     1201 qkrqaeiere tsvriyqyrr pvdsydipkt eeassgflpg drnksrstte lddystnkng
     1261 nnkyldqign mtssqrrskk eqvpsgaele rqqilqemrk rtplhndnsw irqrsasvnk
     1321 epvslpgimr rgesldnlds prsnswrqpp wlnqptgfya sssvqdfsrp ppqlvstsnr
     1381 aymrnpsssv pppsagsvkt sttgvattqs ptprshspsa sqsgsqlrnr svsgkricsy
     1441 cnnilgkgaa miieslglcy hlhcfkcvac ecdlggsssg aevrirnhql ycndcylrfk
     1501 sgrptam
//
LOCUS       XP_047286280            1291 aa            linear   PRI 05-AUG-2025
DEFINITION  LIM domain only protein 7 isoform X18 [Homo sapiens].
ACCESSION   XP_047286280
VERSION     XP_047286280.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430324.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1291
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1291
                     /product="LIM domain only protein 7 isoform X18"
                     /calculated_mol_wt=146891
     Region          9..>89
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Region          261..408
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Site            order(673..674,677..681,690,693,725,729,732..733)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467153"
     Region          676..744
                     /region_name="PDZ"
                     /note="Domain present in PSD-95, Dlg, and ZO-1/2;
                     smart00228"
                     /db_xref="CDD:214570"
     Region          <848..904
                     /region_name="GBP_C"
                     /note="Guanylate-binding protein, C-terminal domain;
                     cd16269"
                     /db_xref="CDD:293879"
     Region          <851..>1006
                     /region_name="DUF5401"
                     /note="Family of unknown function (DUF5401); pfam17380"
                     /db_xref="CDD:375164"
     Region          891..902
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:293879"
     CDS             1..1291
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /coded_by="XM_047430324.1:631..4506"
                     /db_xref="GeneID:4008"
                     /db_xref="HGNC:HGNC:6646"
                     /db_xref="MIM:604362"
ORIGIN      
        1 mqdynkddms yrrisavepk talpfnrflp nksrqpsyvp aplrkkkpdk hednrrswas
       61 pvyteadgtf ssqflllqal qtysddilss ethtkidpts gprlitrrkn lsyapgyrrd
      121 dlemaaldpd lenddffvrk tgafhanpyv lrafedfrkf seqddsverd iilqcregel
      181 vlpdlekddm ivrripaqkk evplsgapdr yhpvpfpepw tlppeiqakf lcvlertcps
      241 keksnscril vpsyrqkkdd mltrkiqswk lgttvppisf tpgpcseadl krweaireas
      301 rlrhkkrlmv erlfqkiyge ngsksmsdvs aedvqnlrql ryeemqkiks qlkeqdqkwq
      361 ddlakwkdrr ksytsdlqkk keereeiekq alekskrssk tfkemlqdre sqnqkstvps
      421 rrrmysfddv leegkrpptm tvseasyqse rveekgatyp seipkedstt fakredrvtt
      481 eiqlpsqspv eeqspaslss lrsrstqmes trvsaslprs yrktdtvrlt svvtprpfgs
      541 qtrgisslpr sytmddawky ngdvedikrt pnnvvstpap spdasqlass lssqkevaat
      601 eedvtrlpsp tspfsslsqd qaatskatls stsgldlmse sgegeispqr evsrsqdqfs
      661 dmrisinqtp gksldfgfti kwdipgifva sveagspaef sqlqvddeii ainntkfsyn
      721 dskeweeama kaqetghlvm dvrrygkags petkwidats giynsekssn lsvttdfses
      781 lqssnieske ingihdesna feskasesis lknlkrrsqf feqgssdsvv pdlpvptisa
      841 psrwvwdqee erkrqerwqk eqdrllqeky qreqeklree wqrakqeaer enskyldeel
      901 mvlssnsmsl ttrepslatw eatwsegsks sdregtrage eerrqpqeev vhedqgkkpq
      961 dqlviererk weqqlqeeqe qkrlqaeaee qkrpaeeqkr qaeieretsv riyqyrrpvd
     1021 sydipkteea ssgflpgdrn ksrstteldd ystnkngnnk yldqignmts sqrrskkeqv
     1081 psgaelerqq ilqemrkrtp lhndnswirq rsasvnkepv slpgimrrge sldnldsprs
     1141 nswrqppwln qptgfyasss vqdfsrpppq lvstsnraym rnpsssvppp sagsvktstt
     1201 gvattqsptp rshspsasqs gsqlrnsvlp vsvtsealpq elksgsettn ctattaisds
     1261 nldgqppcdv slhtkallqi eeevvaahvd l
//
LOCUS       XP_047286281            1549 aa            linear   PRI 05-AUG-2025
DEFINITION  LIM domain only protein 7 isoform X19 [Homo sapiens].
ACCESSION   XP_047286281
VERSION     XP_047286281.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430325.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1549
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1549
                     /product="LIM domain only protein 7 isoform X19"
                     /calculated_mol_wt=176858
     Region          <42..100
                     /region_name="CH_SF"
                     /note="calponin homology (CH) domain superfamily; cl00030"
                     /db_xref="CDD:469584"
     Site            order(42,45..46,48,62..66,84,86..87,89..90,93..94,97)
                     /site_type="other"
                     /note="actin binding site [polypeptide binding]"
                     /db_xref="CDD:409031"
     Region          213..>293
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Region          465..612
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Site            order(877..878,881..885,894,897,929,933,936..937)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467153"
     Region          880..948
                     /region_name="PDZ"
                     /note="Domain present in PSD-95, Dlg, and ZO-1/2;
                     smart00228"
                     /db_xref="CDD:214570"
     Region          <1096..>1344
                     /region_name="DUF5401"
                     /note="Family of unknown function (DUF5401); pfam17380"
                     /db_xref="CDD:375164"
     Region          1480..1538
                     /region_name="LIM"
                     /note="LIM is a small protein-protein interaction domain,
                     containing two zinc fingers; cd08368"
                     /db_xref="CDD:259829"
     Site            order(1480,1483,1503,1506,1509,1512,1534,1537)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..1549
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /coded_by="XM_047430325.1:14..4663"
                     /db_xref="GeneID:4008"
                     /db_xref="HGNC:HGNC:6646"
                     /db_xref="MIM:604362"
ORIGIN      
        1 mpghkiarlc mlwrterlyk pyvfffkyty awvlllplll tdninvflka ceqiglkeaq
       61 lfhpgdlqdl snrvtvkqee tdrrvknvli tlywlgrkaq snpyyngphl nlkafenllg
      121 qaltkaleds sflkrsgrds gygdiwcper geflapprhh kredsfesld slgsrsltsc
      181 ssditlrggr egfesdtdse ftfkmqdynk ddmsyrrisa vepktalpfn rflpnksrqp
      241 syvpaplrkk kpdkhednrr swaspvytea dgtfssqfll lqalqtysdd ilssethtki
      301 dptsgprlit rrknlsyapg yrrddlemaa ldpdlenddf fvrktgafha npyvlrafed
      361 frkfseqdds verdiilqcr egelvlpdle kddmivrrip aqkkevplsg apdryhpvpf
      421 pepwtlppei qakflcvler tcpskeksns crilvpsyrq kkddmltrki qswklgttvp
      481 pisftpgpcs eadlkrweai reasrlrhkk rlmverlfqk iygengsksm sdvsaedvqn
      541 lrqlryeemq kiksqlkeqd qkwqddlakw kdrrksytsd lqkkkeeree iekqaleksk
      601 rssktfkeml qdresqnqks tvpsrrrmys fddvleegkr pptmtvseas yqserveekg
      661 atypseipke dsttfakred rvtteiqlps qspveeqspa slsslrsrst qmestrvsas
      721 lprsyrktdt vrltsvvtpr pfgsqtrgis slprsytmdd awkyngdved ikrtpnnvvs
      781 tpapspdasq lasslssqke vaateedvtr lpsptspfss lsqdqaatsk atlsstsgld
      841 lmsesgegei spqrevsrsq dqfsdmrisi nqtpgksldf gftikwdipg ifvasveags
      901 paefsqlqvd deiiainntk fsyndskewe eamakaqetg hlvmdvrryg kadwgkdqps
      961 lpfirhktln ltsmatkiig spetkwidat sgiynsekss nlsvttdfse slqssniesk
     1021 eingihdesn afeskasesi slknlkrrsq ffeqgssgfs ysswvylcgs sdsvvpdlpv
     1081 ptisapsrwv wdqeeerkrq erwqkeqdrl lqekyqreqe klreewqrak qeaerensky
     1141 ldeelmvlss nsmslttrep slatweatws egskssdreg trageeerrq pqeevvhedq
     1201 gkkpqdqlvi ererkweqql qeeqeqkrlq aeaeeqkrpa eeqkrqaeie retsvriyqy
     1261 rrpvdsydip kteeassgfl pgdrnksrst telddystnk ngnnkyldqi gnmtssqrrs
     1321 kkeqvpsgae lerqqilqem rkrtplhndn swirqrsasv nkepvslpgi mrrgesldnl
     1381 dsprsnswrq ppwlnqptgf yasssvqdfs rpppqlvsts nraymrnpss svpppsagsv
     1441 ktsttgvatt qsptprshsp sasqsgsqlr nrsvsgkric sycnnilgkg aamiieslgl
     1501 cyhlhcfkcv acecdlggss sgaevrirnh qlycndcylr fksgrptam
//
LOCUS       XP_047286282            1507 aa            linear   PRI 05-AUG-2025
DEFINITION  LIM domain only protein 7 isoform X17 [Homo sapiens].
ACCESSION   XP_047286282
VERSION     XP_047286282.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430326.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1507
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1507
                     /product="LIM domain only protein 7 isoform X17"
                     /calculated_mol_wt=171920
     Region          9..>71
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Region          423..570
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Site            order(835..836,839..843,852,855,887,891,894..895)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467153"
     Region          838..906
                     /region_name="PDZ"
                     /note="Domain present in PSD-95, Dlg, and ZO-1/2;
                     smart00228"
                     /db_xref="CDD:214570"
     Region          <1051..1107
                     /region_name="GBP_C"
                     /note="Guanylate-binding protein, C-terminal domain;
                     cd16269"
                     /db_xref="CDD:293879"
     Region          <1054..>1209
                     /region_name="DUF5401"
                     /note="Family of unknown function (DUF5401); pfam17380"
                     /db_xref="CDD:375164"
     Region          1094..1105
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:293879"
     Region          1438..1496
                     /region_name="LIM"
                     /note="LIM is a small protein-protein interaction domain,
                     containing two zinc fingers; cd08368"
                     /db_xref="CDD:259829"
     Site            order(1438,1441,1461,1464,1467,1470,1492,1495)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..1507
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /coded_by="XM_047430326.1:613..5136"
                     /db_xref="GeneID:4008"
                     /db_xref="HGNC:HGNC:6646"
                     /db_xref="MIM:604362"
ORIGIN      
        1 mqdynkddms yrrisavepk talpfnrflp nksrqpsyvp aplrkkkpdk hednrrswas
       61 pvyteadgtf ssnqrriwgt nvenwptvqg tsksscylee ekaktrsipn ivkddlyvrk
      121 lspvmpnpgn afdqflpkcw tpedvnwkri kretykpwyk efqgfsrrns dsededsgsd
      181 rsatvfsraq kaehrldgnc qrpslllela tkravkspds haarrsssas depsqflllq
      241 alqtysddil ssethtkidp tsgprlitrr knlsyapgyr rddlemaald pdlenddffv
      301 rktgafhanp yvlrafedfr kfseqddsve rdiilqcreg elvlpdlekd dmivrripaq
      361 kkevplsgap dryhpvpfpe pwtlppeiqa kflcvlertc pskeksnscr ilvpsyrqkk
      421 ddmltrkiqs wklgttvppi sftpgpcsea dlkrweaire asrlrhkkrl mverlfqkiy
      481 gengsksmsd vsaedvqnlr qlryeemqki ksqlkeqdqk wqddlakwkd rrksytsdlq
      541 kkkeereeie kqalekskrs sktfkemlqd resqnqkstv psrrrmysfd dvleegkrpp
      601 tmtvseasyq serveekgat ypseipkeds ttfakredrv tteiqlpsqs pveeqspasl
      661 sslrsrstqm estrvsaslp rsyrktdtvr ltsvvtprpf gsqtrgissl prsytmddaw
      721 kyngdvedik rtpnnvvstp apspdasqla sslssqkeva ateedvtrlp sptspfssls
      781 qdqaatskat lsstsgldlm sesgegeisp qrevsrsqdq fsdmrisinq tpgksldfgf
      841 tikwdipgif vasveagspa efsqlqvdde iiainntkfs yndskeweea makaqetghl
      901 vmdvrrygka dwgkdqpslp firhktlnlt smatkiigsp etkwidatsg iynsekssnl
      961 svttdfsesl qssnieskei ngihdesnaf eskasesisl knlkrrsqff eqgssgfsys
     1021 swvylcgssd svvpdlpvpt isapsrwvwd qeeerkrqer wqkeqdrllq ekyqreqekl
     1081 reewqrakqe aerenskyld eelmvlssns mslttrepsl atweatwseg skssdregtr
     1141 ageeerrqpq eevvhedqgk kpqdqlvier erkweqqlqe eqeqkrlqae aeeqkrpaee
     1201 qkrqaeiere tsvriyqyrr pvdsydipkt eeassgflpg drnksrstte lddystnkng
     1261 nnkyldqign mtssqrrskk eqvpsgaele rqqilqemrk rtplhndnsw irqrsasvnk
     1321 epvslpgimr rgesldnlds prsnswrqpp wlnqptgfya sssvqdfsrp ppqlvstsnr
     1381 aymrnpsssv pppsagsvkt sttgvattqs ptprshspsa sqsgsqlrnr svsgkricsy
     1441 cnnilgkgaa miieslglcy hlhcfkcvac ecdlggsssg aevrirnhql ycndcylrfk
     1501 sgrptam
//
LOCUS       XP_047286283            1507 aa            linear   PRI 05-AUG-2025
DEFINITION  LIM domain only protein 7 isoform X17 [Homo sapiens].
ACCESSION   XP_047286283
VERSION     XP_047286283.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430327.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 3% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1507
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1507
                     /product="LIM domain only protein 7 isoform X17"
                     /calculated_mol_wt=171920
     Region          9..>71
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Region          423..570
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Site            order(835..836,839..843,852,855,887,891,894..895)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467153"
     Region          838..906
                     /region_name="PDZ"
                     /note="Domain present in PSD-95, Dlg, and ZO-1/2;
                     smart00228"
                     /db_xref="CDD:214570"
     Region          <1051..1107
                     /region_name="GBP_C"
                     /note="Guanylate-binding protein, C-terminal domain;
                     cd16269"
                     /db_xref="CDD:293879"
     Region          <1054..>1209
                     /region_name="DUF5401"
                     /note="Family of unknown function (DUF5401); pfam17380"
                     /db_xref="CDD:375164"
     Region          1094..1105
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:293879"
     Region          1438..1496
                     /region_name="LIM"
                     /note="LIM is a small protein-protein interaction domain,
                     containing two zinc fingers; cd08368"
                     /db_xref="CDD:259829"
     Site            order(1438,1441,1461,1464,1467,1470,1492,1495)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..1507
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /coded_by="XM_047430327.1:735..5258"
                     /db_xref="GeneID:4008"
                     /db_xref="HGNC:HGNC:6646"
                     /db_xref="MIM:604362"
ORIGIN      
        1 mqdynkddms yrrisavepk talpfnrflp nksrqpsyvp aplrkkkpdk hednrrswas
       61 pvyteadgtf ssnqrriwgt nvenwptvqg tsksscylee ekaktrsipn ivkddlyvrk
      121 lspvmpnpgn afdqflpkcw tpedvnwkri kretykpwyk efqgfsrrns dsededsgsd
      181 rsatvfsraq kaehrldgnc qrpslllela tkravkspds haarrsssas depsqflllq
      241 alqtysddil ssethtkidp tsgprlitrr knlsyapgyr rddlemaald pdlenddffv
      301 rktgafhanp yvlrafedfr kfseqddsve rdiilqcreg elvlpdlekd dmivrripaq
      361 kkevplsgap dryhpvpfpe pwtlppeiqa kflcvlertc pskeksnscr ilvpsyrqkk
      421 ddmltrkiqs wklgttvppi sftpgpcsea dlkrweaire asrlrhkkrl mverlfqkiy
      481 gengsksmsd vsaedvqnlr qlryeemqki ksqlkeqdqk wqddlakwkd rrksytsdlq
      541 kkkeereeie kqalekskrs sktfkemlqd resqnqkstv psrrrmysfd dvleegkrpp
      601 tmtvseasyq serveekgat ypseipkeds ttfakredrv tteiqlpsqs pveeqspasl
      661 sslrsrstqm estrvsaslp rsyrktdtvr ltsvvtprpf gsqtrgissl prsytmddaw
      721 kyngdvedik rtpnnvvstp apspdasqla sslssqkeva ateedvtrlp sptspfssls
      781 qdqaatskat lsstsgldlm sesgegeisp qrevsrsqdq fsdmrisinq tpgksldfgf
      841 tikwdipgif vasveagspa efsqlqvdde iiainntkfs yndskeweea makaqetghl
      901 vmdvrrygka dwgkdqpslp firhktlnlt smatkiigsp etkwidatsg iynsekssnl
      961 svttdfsesl qssnieskei ngihdesnaf eskasesisl knlkrrsqff eqgssgfsys
     1021 swvylcgssd svvpdlpvpt isapsrwvwd qeeerkrqer wqkeqdrllq ekyqreqekl
     1081 reewqrakqe aerenskyld eelmvlssns mslttrepsl atweatwseg skssdregtr
     1141 ageeerrqpq eevvhedqgk kpqdqlvier erkweqqlqe eqeqkrlqae aeeqkrpaee
     1201 qkrqaeiere tsvriyqyrr pvdsydipkt eeassgflpg drnksrstte lddystnkng
     1261 nnkyldqign mtssqrrskk eqvpsgaele rqqilqemrk rtplhndnsw irqrsasvnk
     1321 epvslpgimr rgesldnlds prsnswrqpp wlnqptgfya sssvqdfsrp ppqlvstsnr
     1381 aymrnpsssv pppsagsvkt sttgvattqs ptprshspsa sqsgsqlrnr svsgkricsy
     1441 cnnilgkgaa miieslglcy hlhcfkcvac ecdlggsssg aevrirnhql ycndcylrfk
     1501 sgrptam
//
LOCUS       XP_047286284            1507 aa            linear   PRI 05-AUG-2025
DEFINITION  LIM domain only protein 7 isoform X17 [Homo sapiens].
ACCESSION   XP_047286284
VERSION     XP_047286284.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430328.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1507
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1507
                     /product="LIM domain only protein 7 isoform X17"
                     /calculated_mol_wt=171920
     Region          9..>71
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Region          423..570
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Site            order(835..836,839..843,852,855,887,891,894..895)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467153"
     Region          838..906
                     /region_name="PDZ"
                     /note="Domain present in PSD-95, Dlg, and ZO-1/2;
                     smart00228"
                     /db_xref="CDD:214570"
     Region          <1051..1107
                     /region_name="GBP_C"
                     /note="Guanylate-binding protein, C-terminal domain;
                     cd16269"
                     /db_xref="CDD:293879"
     Region          <1054..>1209
                     /region_name="DUF5401"
                     /note="Family of unknown function (DUF5401); pfam17380"
                     /db_xref="CDD:375164"
     Region          1094..1105
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:293879"
     Region          1438..1496
                     /region_name="LIM"
                     /note="LIM is a small protein-protein interaction domain,
                     containing two zinc fingers; cd08368"
                     /db_xref="CDD:259829"
     Site            order(1438,1441,1461,1464,1467,1470,1492,1495)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..1507
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /coded_by="XM_047430328.1:536..5059"
                     /db_xref="GeneID:4008"
                     /db_xref="HGNC:HGNC:6646"
                     /db_xref="MIM:604362"
ORIGIN      
        1 mqdynkddms yrrisavepk talpfnrflp nksrqpsyvp aplrkkkpdk hednrrswas
       61 pvyteadgtf ssnqrriwgt nvenwptvqg tsksscylee ekaktrsipn ivkddlyvrk
      121 lspvmpnpgn afdqflpkcw tpedvnwkri kretykpwyk efqgfsrrns dsededsgsd
      181 rsatvfsraq kaehrldgnc qrpslllela tkravkspds haarrsssas depsqflllq
      241 alqtysddil ssethtkidp tsgprlitrr knlsyapgyr rddlemaald pdlenddffv
      301 rktgafhanp yvlrafedfr kfseqddsve rdiilqcreg elvlpdlekd dmivrripaq
      361 kkevplsgap dryhpvpfpe pwtlppeiqa kflcvlertc pskeksnscr ilvpsyrqkk
      421 ddmltrkiqs wklgttvppi sftpgpcsea dlkrweaire asrlrhkkrl mverlfqkiy
      481 gengsksmsd vsaedvqnlr qlryeemqki ksqlkeqdqk wqddlakwkd rrksytsdlq
      541 kkkeereeie kqalekskrs sktfkemlqd resqnqkstv psrrrmysfd dvleegkrpp
      601 tmtvseasyq serveekgat ypseipkeds ttfakredrv tteiqlpsqs pveeqspasl
      661 sslrsrstqm estrvsaslp rsyrktdtvr ltsvvtprpf gsqtrgissl prsytmddaw
      721 kyngdvedik rtpnnvvstp apspdasqla sslssqkeva ateedvtrlp sptspfssls
      781 qdqaatskat lsstsgldlm sesgegeisp qrevsrsqdq fsdmrisinq tpgksldfgf
      841 tikwdipgif vasveagspa efsqlqvdde iiainntkfs yndskeweea makaqetghl
      901 vmdvrrygka dwgkdqpslp firhktlnlt smatkiigsp etkwidatsg iynsekssnl
      961 svttdfsesl qssnieskei ngihdesnaf eskasesisl knlkrrsqff eqgssgfsys
     1021 swvylcgssd svvpdlpvpt isapsrwvwd qeeerkrqer wqkeqdrllq ekyqreqekl
     1081 reewqrakqe aerenskyld eelmvlssns mslttrepsl atweatwseg skssdregtr
     1141 ageeerrqpq eevvhedqgk kpqdqlvier erkweqqlqe eqeqkrlqae aeeqkrpaee
     1201 qkrqaeiere tsvriyqyrr pvdsydipkt eeassgflpg drnksrstte lddystnkng
     1261 nnkyldqign mtssqrrskk eqvpsgaele rqqilqemrk rtplhndnsw irqrsasvnk
     1321 epvslpgimr rgesldnlds prsnswrqpp wlnqptgfya sssvqdfsrp ppqlvstsnr
     1381 aymrnpsssv pppsagsvkt sttgvattqs ptprshspsa sqsgsqlrnr svsgkricsy
     1441 cnnilgkgaa miieslglcy hlhcfkcvac ecdlggsssg aevrirnhql ycndcylrfk
     1501 sgrptam
//
LOCUS       XP_047286285            1439 aa            linear   PRI 05-AUG-2025
DEFINITION  LIM domain only protein 7 isoform X20 [Homo sapiens].
ACCESSION   XP_047286285
VERSION     XP_047286285.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430329.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1439
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1439
                     /product="LIM domain only protein 7 isoform X20"
                     /calculated_mol_wt=164510
     Region          9..>71
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Region          355..502
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Site            order(767..768,771..775,784,787,819,823,826..827)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467153"
     Region          770..838
                     /region_name="PDZ"
                     /note="Domain present in PSD-95, Dlg, and ZO-1/2;
                     smart00228"
                     /db_xref="CDD:214570"
     Region          <983..1039
                     /region_name="GBP_C"
                     /note="Guanylate-binding protein, C-terminal domain;
                     cd16269"
                     /db_xref="CDD:293879"
     Region          <986..>1267
                     /region_name="DUF5401"
                     /note="Family of unknown function (DUF5401); pfam17380"
                     /db_xref="CDD:375164"
     Region          1026..1037
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:293879"
     Region          1370..1428
                     /region_name="LIM"
                     /note="LIM is a small protein-protein interaction domain,
                     containing two zinc fingers; cd08368"
                     /db_xref="CDD:259829"
     Site            order(1370,1373,1393,1396,1399,1402,1424,1427)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..1439
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /coded_by="XM_047430329.1:786..5105"
                     /db_xref="GeneID:4008"
                     /db_xref="HGNC:HGNC:6646"
                     /db_xref="MIM:604362"
ORIGIN      
        1 mqdynkddms yrrisavepk talpfnrflp nksrqpsyvp aplrkkkpdk hednrrswas
       61 pvyteadgtf ssnqrriwgt nvenwptvqg tsksscylee ekaktrsipn ivkddlyvrk
      121 lspvmpnpgn afdqflpkcw tpedvnwkri kretykpwyk efqgfsqfll lqalqtysdd
      181 ilssethtki dptsgprlit rrknlsyapg yrrddlemaa ldpdlenddf fvrktgafha
      241 npyvlrafed frkfseqdds verdiilqcr egelvlpdle kddmivrrip aqkkevplsg
      301 apdryhpvpf pepwtlppei qakflcvler tcpskeksns crilvpsyrq kkddmltrki
      361 qswklgttvp pisftpgpcs eadlkrweai reasrlrhkk rlmverlfqk iygengsksm
      421 sdvsaedvqn lrqlryeemq kiksqlkeqd qkwqddlakw kdrrksytsd lqkkkeeree
      481 iekqaleksk rssktfkeml qdresqnqks tvpsrrrmys fddvleegkr pptmtvseas
      541 yqserveekg atypseipke dsttfakred rvtteiqlps qspveeqspa slsslrsrst
      601 qmestrvsas lprsyrktdt vrltsvvtpr pfgsqtrgis slprsytmdd awkyngdved
      661 ikrtpnnvvs tpapspdasq lasslssqke vaateedvtr lpsptspfss lsqdqaatsk
      721 atlsstsgld lmsesgegei spqrevsrsq dqfsdmrisi nqtpgksldf gftikwdipg
      781 ifvasveags paefsqlqvd deiiainntk fsyndskewe eamakaqetg hlvmdvrryg
      841 kadwgkdqps lpfirhktln ltsmatkiig spetkwidat sgiynsekss nlsvttdfse
      901 slqssniesk eingihdesn afeskasesi slknlkrrsq ffeqgssgfs ysswvylcgs
      961 sdsvvpdlpv ptisapsrwv wdqeeerkrq erwqkeqdrl lqekyqreqe klreewqrak
     1021 qeaerensky ldeelmvlss nsmslttrep slatweatws egskssdreg trageeerrq
     1081 pqeevvhedq gkkpqdqlvi ererkweqql qeeqeqkrlq aeaeeqkrpa eeqkrqaeie
     1141 retsvriyqy rrpvdsydip kteeassgfl pgdrnksrst telddystnk ngnnkyldqi
     1201 gnmtssqrrs kkeqvpsgae lerqqilqem rkrtplhndn swirqrsasv nkepvslpgi
     1261 mrrgesldnl dsprsnswrq ppwlnqptgf yasssvqdfs rpppqlvsts nraymrnpss
     1321 svpppsagsv ktsttgvatt qsptprshsp sasqsgsqlr nrsvsgkric sycnnilgkg
     1381 aamiieslgl cyhlhcfkcv acecdlggss sgaevrirnh qlycndcylr fksgrptam
//
LOCUS       XP_047286286            1095 aa            linear   PRI 05-AUG-2025
DEFINITION  LIM domain only protein 7 isoform X21 [Homo sapiens].
ACCESSION   XP_047286286
VERSION     XP_047286286.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430330.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1095
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1095
                     /product="LIM domain only protein 7 isoform X21"
                     /calculated_mol_wt=124396
     Region          9..158
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Site            order(423..424,427..431,440,443,475,479,482..483)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467153"
     Region          426..494
                     /region_name="PDZ"
                     /note="Domain present in PSD-95, Dlg, and ZO-1/2;
                     smart00228"
                     /db_xref="CDD:214570"
     Region          <639..695
                     /region_name="GBP_C"
                     /note="Guanylate-binding protein, C-terminal domain;
                     cd16269"
                     /db_xref="CDD:293879"
     Region          <642..>797
                     /region_name="DUF5401"
                     /note="Family of unknown function (DUF5401); pfam17380"
                     /db_xref="CDD:375164"
     Region          682..693
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:293879"
     Region          1026..1084
                     /region_name="LIM"
                     /note="LIM is a small protein-protein interaction domain,
                     containing two zinc fingers; cd08368"
                     /db_xref="CDD:259829"
     Site            order(1026,1029,1049,1052,1055,1058,1080,1083)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..1095
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /coded_by="XM_047430330.1:631..3918"
                     /db_xref="GeneID:4008"
                     /db_xref="HGNC:HGNC:6646"
                     /db_xref="MIM:604362"
ORIGIN      
        1 mqdynkddms yrrisavepk talpfnrflp nksrqpsyvp aplrkkkpdk hednrrswas
       61 pvyteadgtf srsksmsdvs aedvqnlrql ryeemqkiks qlkeqdqkwq ddlakwkdrr
      121 ksytsdlqkk keereeiekq alekskrssk tfkemlqdre sqnqkstvps rrrmysfddv
      181 leegkrpptm tvseasyqse rveekgatyp seipkedstt fakredrvtt eiqlpsqspv
      241 eeqspaslss lrsrstqmes trvsaslprs yrktdtvrlt svvtprpfgs qtrgisslpr
      301 sytmddawky ngdvedikrt pnnvvstpap spdasqlass lssqkevaat eedvtrlpsp
      361 tspfsslsqd qaatskatls stsgldlmse sgegeispqr evsrsqdqfs dmrisinqtp
      421 gksldfgfti kwdipgifva sveagspaef sqlqvddeii ainntkfsyn dskeweeama
      481 kaqetghlvm dvrrygkadw gkdqpslpfi rhktlnltsm atkiigspet kwidatsgiy
      541 nsekssnlsv ttdfseslqs snieskeing ihdesnafes kasesislkn lkrrsqffeq
      601 gssgfsyssw vylcgssdsv vpdlpvptis apsrwvwdqe eerkrqerwq keqdrllqek
      661 yqreqeklre ewqrakqeae renskyldee lmvlssnsms lttrepslat weatwsegsk
      721 ssdregtrag eeerrqpqee vvhedqgkkp qdqlvierer kweqqlqeeq eqkrlqaeae
      781 eqkrpaeeqk rqaeierets vriyqyrrpv dsydipktee assgflpgdr nksrstteld
      841 dystnkngnn kyldqignmt ssqrrskkeq vpsgaelerq qilqemrkrt plhndnswir
      901 qrsasvnkep vslpgimrrg esldnldspr snswrqppwl nqptgfyass svqdfsrppp
      961 qlvstsnray mrnpsssvpp psagsvktst tgvattqspt prshspsasq sgsqlrnrsv
     1021 sgkricsycn nilgkgaami ieslglcyhl hcfkcvacec dlggsssgae vrirnhqlyc
     1081 ndcylrfksg rptam
//
LOCUS       XP_011533397            1091 aa            linear   PRI 05-AUG-2025
DEFINITION  LIM domain only protein 7 isoform X22 [Homo sapiens].
ACCESSION   XP_011533397
VERSION     XP_011533397.3
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535095.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XP_011533397.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1091
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1091
                     /product="LIM domain only protein 7 isoform X22"
                     /calculated_mol_wt=124022
     Region          9..168
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Site            order(433..434,437..441,450,453,485,489,492..493)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467153"
     Region          436..504
                     /region_name="PDZ"
                     /note="Domain present in PSD-95, Dlg, and ZO-1/2;
                     smart00228"
                     /db_xref="CDD:214570"
     Region          <635..691
                     /region_name="GBP_C"
                     /note="Guanylate-binding protein, C-terminal domain;
                     cd16269"
                     /db_xref="CDD:293879"
     Region          <638..>793
                     /region_name="DUF5401"
                     /note="Family of unknown function (DUF5401); pfam17380"
                     /db_xref="CDD:375164"
     Region          678..689
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:293879"
     Region          1022..1080
                     /region_name="LIM"
                     /note="LIM is a small protein-protein interaction domain,
                     containing two zinc fingers; cd08368"
                     /db_xref="CDD:259829"
     Site            order(1022,1025,1045,1048,1051,1054,1076,1079)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..1091
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /coded_by="XM_011535095.3:631..3906"
                     /db_xref="GeneID:4008"
                     /db_xref="HGNC:HGNC:6646"
                     /db_xref="MIM:604362"
ORIGIN      
        1 mqdynkddms yrrisavepk talpfnrflp nksrqpsyvp aplrkkkpdk hednrrswas
       61 pvyteadgtf srlfqkiyge ngsksmsdvs aedvqnlrql ryeemqkiks qlkeqdqkwq
      121 ddlakwkdrr ksytsdlqkk keereeiekq alekskrssk tfkemlqdre sqnqkstvps
      181 rrrmysfddv leegkrpptm tvseasyqse rveekgatyp seipkedstt fakredrvtt
      241 eiqlpsqspv eeqspaslss lrsrstqmes trvsaslprs yrktdtvrlt svvtprpfgs
      301 qtrgisslpr sytmddawky ngdvedikrt pnnvvstpap spdasqlass lssqkevaat
      361 eedvtrlpsp tspfsslsqd qaatskatls stsgldlmse sgegeispqr evsrsqdqfs
      421 dmrisinqtp gksldfgfti kwdipgifva sveagspaef sqlqvddeii ainntkfsyn
      481 dskeweeama kaqetghlvm dvrrygkadw gkdqpslpfi rhktlnltsm atkiigspet
      541 kwidatsgiy nsekssnlsv ttdfseslqs snieskeing ihdesnafes kasesislkn
      601 lkrrsqffeq gssdsvvpdl pvptisapsr wvwdqeeerk rqerwqkeqd rllqekyqre
      661 qeklreewqr akqeaerens kyldeelmvl ssnsmslttr epslatweat wsegskssdr
      721 egtrageeer rqpqeevvhe dqgkkpqdql viererkweq qlqeeqeqkr lqaeaeeqkr
      781 paeeqkrqae ieretsvriy qyrrpvdsyd ipkteeassg flpgdrnksr sttelddyst
      841 nkngnnkyld qignmtssqr rskkeqvpsg aelerqqilq emrkrtplhn dnswirqrsa
      901 svnkepvslp gimrrgesld nldsprsnsw rqppwlnqpt gfyasssvqd fsrpppqlvs
      961 tsnraymrnp sssvpppsag svktsttgva ttqsptprsh spsasqsgsq lrnrsvsgkr
     1021 icsycnnilg kgaamiiesl glcyhlhcfk cvacecdlgg sssgaevrir nhqlycndcy
     1081 lrfksgrpta m
//
LOCUS       XP_047286287            1078 aa            linear   PRI 05-AUG-2025
DEFINITION  LIM domain only protein 7 isoform X23 [Homo sapiens].
ACCESSION   XP_047286287
VERSION     XP_047286287.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430331.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1078
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1078
                     /product="LIM domain only protein 7 isoform X23"
                     /calculated_mol_wt=122453
     Region          9..168
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Site            order(433..434,437..441,450,453,485,489,492..493)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467153"
     Region          436..504
                     /region_name="PDZ"
                     /note="Domain present in PSD-95, Dlg, and ZO-1/2;
                     smart00228"
                     /db_xref="CDD:214570"
     Region          <622..678
                     /region_name="GBP_C"
                     /note="Guanylate-binding protein, C-terminal domain;
                     cd16269"
                     /db_xref="CDD:293879"
     Region          <625..>780
                     /region_name="DUF5401"
                     /note="Family of unknown function (DUF5401); pfam17380"
                     /db_xref="CDD:375164"
     Region          665..676
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:293879"
     Region          1009..1067
                     /region_name="LIM"
                     /note="LIM is a small protein-protein interaction domain,
                     containing two zinc fingers; cd08368"
                     /db_xref="CDD:259829"
     Site            order(1009,1012,1032,1035,1038,1041,1063,1066)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..1078
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /coded_by="XM_047430331.1:631..3867"
                     /db_xref="GeneID:4008"
                     /db_xref="HGNC:HGNC:6646"
                     /db_xref="MIM:604362"
ORIGIN      
        1 mqdynkddms yrrisavepk talpfnrflp nksrqpsyvp aplrkkkpdk hednrrswas
       61 pvyteadgtf srlfqkiyge ngsksmsdvs aedvqnlrql ryeemqkiks qlkeqdqkwq
      121 ddlakwkdrr ksytsdlqkk keereeiekq alekskrssk tfkemlqdre sqnqkstvps
      181 rrrmysfddv leegkrpptm tvseasyqse rveekgatyp seipkedstt fakredrvtt
      241 eiqlpsqspv eeqspaslss lrsrstqmes trvsaslprs yrktdtvrlt svvtprpfgs
      301 qtrgisslpr sytmddawky ngdvedikrt pnnvvstpap spdasqlass lssqkevaat
      361 eedvtrlpsp tspfsslsqd qaatskatls stsgldlmse sgegeispqr evsrsqdqfs
      421 dmrisinqtp gksldfgfti kwdipgifva sveagspaef sqlqvddeii ainntkfsyn
      481 dskeweeama kaqetghlvm dvrrygkags petkwidats giynsekssn lsvttdfses
      541 lqssnieske ingihdesna feskasesis lknlkrrsqf feqgssgfsy sswvylcgss
      601 dsvvpdlpvp tisapsrwvw dqeeerkrqe rwqkeqdrll qekyqreqek lreewqrakq
      661 eaerenskyl deelmvlssn smslttreps latweatwse gskssdregt rageeerrqp
      721 qeevvhedqg kkpqdqlvie rerkweqqlq eeqeqkrlqa eaeeqkrpae eqkrqaeier
      781 etsvriyqyr rpvdsydipk teeassgflp gdrnksrstt elddystnkn gnnkyldqig
      841 nmtssqrrsk keqvpsgael erqqilqemr krtplhndns wirqrsasvn kepvslpgim
      901 rrgesldnld sprsnswrqp pwlnqptgfy asssvqdfsr pppqlvstsn raymrnpsss
      961 vpppsagsvk tsttgvattq sptprshsps asqsgsqlrn rsvsgkrics ycnnilgkga
     1021 amiieslglc yhlhcfkcva cecdlggsss gaevrirnhq lycndcylrf ksgrptam
//
LOCUS       XP_047286289            1078 aa            linear   PRI 05-AUG-2025
DEFINITION  LIM domain only protein 7 isoform X24 [Homo sapiens].
ACCESSION   XP_047286289
VERSION     XP_047286289.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430333.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1078
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1078
                     /product="LIM domain only protein 7 isoform X24"
                     /calculated_mol_wt=122202
     Region          9..168
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Site            order(433..434,437..441,450,453,485,489,492..493)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467153"
     Region          436..504
                     /region_name="PDZ"
                     /note="Domain present in PSD-95, Dlg, and ZO-1/2;
                     smart00228"
                     /db_xref="CDD:214570"
     Region          <635..691
                     /region_name="GBP_C"
                     /note="Guanylate-binding protein, C-terminal domain;
                     cd16269"
                     /db_xref="CDD:293879"
     Region          <638..>793
                     /region_name="DUF5401"
                     /note="Family of unknown function (DUF5401); pfam17380"
                     /db_xref="CDD:375164"
     Region          678..689
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:293879"
     CDS             1..1078
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /coded_by="XM_047430333.1:631..3867"
                     /db_xref="GeneID:4008"
                     /db_xref="HGNC:HGNC:6646"
                     /db_xref="MIM:604362"
ORIGIN      
        1 mqdynkddms yrrisavepk talpfnrflp nksrqpsyvp aplrkkkpdk hednrrswas
       61 pvyteadgtf srlfqkiyge ngsksmsdvs aedvqnlrql ryeemqkiks qlkeqdqkwq
      121 ddlakwkdrr ksytsdlqkk keereeiekq alekskrssk tfkemlqdre sqnqkstvps
      181 rrrmysfddv leegkrpptm tvseasyqse rveekgatyp seipkedstt fakredrvtt
      241 eiqlpsqspv eeqspaslss lrsrstqmes trvsaslprs yrktdtvrlt svvtprpfgs
      301 qtrgisslpr sytmddawky ngdvedikrt pnnvvstpap spdasqlass lssqkevaat
      361 eedvtrlpsp tspfsslsqd qaatskatls stsgldlmse sgegeispqr evsrsqdqfs
      421 dmrisinqtp gksldfgfti kwdipgifva sveagspaef sqlqvddeii ainntkfsyn
      481 dskeweeama kaqetghlvm dvrrygkadw gkdqpslpfi rhktlnltsm atkiigspet
      541 kwidatsgiy nsekssnlsv ttdfseslqs snieskeing ihdesnafes kasesislkn
      601 lkrrsqffeq gssdsvvpdl pvptisapsr wvwdqeeerk rqerwqkeqd rllqekyqre
      661 qeklreewqr akqeaerens kyldeelmvl ssnsmslttr epslatweat wsegskssdr
      721 egtrageeer rqpqeevvhe dqgkkpqdql viererkweq qlqeeqeqkr lqaeaeeqkr
      781 paeeqkrqae ieretsvriy qyrrpvdsyd ipkteeassg flpgdrnksr sttelddyst
      841 nkngnnkyld qignmtssqr rskkeqvpsg aelerqqilq emrkrtplhn dnswirqrsa
      901 svnkepvslp gimrrgesld nldsprsnsw rqppwlnqpt gfyasssvqd fsrpppqlvs
      961 tsnraymrnp sssvpppsag svktsttgva ttqsptprsh spsasqsgsq lrnsvlpvsv
     1021 tsealpqelk sgsettncta ttaisdsnld gqppcdvslh tkallqieee vvaahvdl
//
LOCUS       XP_047286290            1072 aa            linear   PRI 05-AUG-2025
DEFINITION  LIM domain only protein 7 isoform X25 [Homo sapiens].
ACCESSION   XP_047286290
VERSION     XP_047286290.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430334.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1072
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1072
                     /product="LIM domain only protein 7 isoform X25"
                     /calculated_mol_wt=121771
     Region          9..168
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Site            order(433..434,437..441,450,453,485,489,492..493)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467153"
     Region          436..504
                     /region_name="PDZ"
                     /note="Domain present in PSD-95, Dlg, and ZO-1/2;
                     smart00228"
                     /db_xref="CDD:214570"
     Region          <616..672
                     /region_name="GBP_C"
                     /note="Guanylate-binding protein, C-terminal domain;
                     cd16269"
                     /db_xref="CDD:293879"
     Region          <619..>774
                     /region_name="DUF5401"
                     /note="Family of unknown function (DUF5401); pfam17380"
                     /db_xref="CDD:375164"
     Region          659..670
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:293879"
     Region          1003..1061
                     /region_name="LIM"
                     /note="LIM is a small protein-protein interaction domain,
                     containing two zinc fingers; cd08368"
                     /db_xref="CDD:259829"
     Site            order(1003,1006,1026,1029,1032,1035,1057,1060)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..1072
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /coded_by="XM_047430334.1:631..3849"
                     /db_xref="GeneID:4008"
                     /db_xref="HGNC:HGNC:6646"
                     /db_xref="MIM:604362"
ORIGIN      
        1 mqdynkddms yrrisavepk talpfnrflp nksrqpsyvp aplrkkkpdk hednrrswas
       61 pvyteadgtf srlfqkiyge ngsksmsdvs aedvqnlrql ryeemqkiks qlkeqdqkwq
      121 ddlakwkdrr ksytsdlqkk keereeiekq alekskrssk tfkemlqdre sqnqkstvps
      181 rrrmysfddv leegkrpptm tvseasyqse rveekgatyp seipkedstt fakredrvtt
      241 eiqlpsqspv eeqspaslss lrsrstqmes trvsaslprs yrktdtvrlt svvtprpfgs
      301 qtrgisslpr sytmddawky ngdvedikrt pnnvvstpap spdasqlass lssqkevaat
      361 eedvtrlpsp tspfsslsqd qaatskatls stsgldlmse sgegeispqr evsrsqdqfs
      421 dmrisinqtp gksldfgfti kwdipgifva sveagspaef sqlqvddeii ainntkfsyn
      481 dskeweeama kaqetghlvm dvrrygkadw gkdqpslpfi rhktlnltsm atkiigspet
      541 kwidatsgiy nsekssnlsv ttdfseslqs snieskeing ihdesnafes kgssdsvvpd
      601 lpvptisaps rwvwdqeeer krqerwqkeq drllqekyqr eqeklreewq rakqeaeren
      661 skyldeelmv lssnsmsltt repslatwea twsegskssd regtrageee rrqpqeevvh
      721 edqgkkpqdq lviererkwe qqlqeeqeqk rlqaeaeeqk rpaeeqkrqa eieretsvri
      781 yqyrrpvdsy dipkteeass gflpgdrnks rsttelddys tnkngnnkyl dqignmtssq
      841 rrskkeqvps gaelerqqil qemrkrtplh ndnswirqrs asvnkepvsl pgimrrgesl
      901 dnldsprsns wrqppwlnqp tgfyasssvq dfsrpppqlv stsnraymrn psssvpppsa
      961 gsvktsttgv attqsptprs hspsasqsgs qlrnrsvsgk ricsycnnil gkgaamiies
     1021 lglcyhlhcf kcvacecdlg gsssgaevri rnhqlycndc ylrfksgrpt am
//
LOCUS       XP_047286291            1068 aa            linear   PRI 05-AUG-2025
DEFINITION  LIM domain only protein 7 isoform X26 [Homo sapiens].
ACCESSION   XP_047286291
VERSION     XP_047286291.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430335.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1068
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1068
                     /product="LIM domain only protein 7 isoform X26"
                     /calculated_mol_wt=121052
     Region          9..158
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Site            order(423..424,427..431,440,443,475,479,482..483)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467153"
     Region          426..494
                     /region_name="PDZ"
                     /note="Domain present in PSD-95, Dlg, and ZO-1/2;
                     smart00228"
                     /db_xref="CDD:214570"
     Region          <625..681
                     /region_name="GBP_C"
                     /note="Guanylate-binding protein, C-terminal domain;
                     cd16269"
                     /db_xref="CDD:293879"
     Region          <628..>783
                     /region_name="DUF5401"
                     /note="Family of unknown function (DUF5401); pfam17380"
                     /db_xref="CDD:375164"
     Region          668..679
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:293879"
     CDS             1..1068
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /coded_by="XM_047430335.1:631..3837"
                     /db_xref="GeneID:4008"
                     /db_xref="HGNC:HGNC:6646"
                     /db_xref="MIM:604362"
ORIGIN      
        1 mqdynkddms yrrisavepk talpfnrflp nksrqpsyvp aplrkkkpdk hednrrswas
       61 pvyteadgtf srsksmsdvs aedvqnlrql ryeemqkiks qlkeqdqkwq ddlakwkdrr
      121 ksytsdlqkk keereeiekq alekskrssk tfkemlqdre sqnqkstvps rrrmysfddv
      181 leegkrpptm tvseasyqse rveekgatyp seipkedstt fakredrvtt eiqlpsqspv
      241 eeqspaslss lrsrstqmes trvsaslprs yrktdtvrlt svvtprpfgs qtrgisslpr
      301 sytmddawky ngdvedikrt pnnvvstpap spdasqlass lssqkevaat eedvtrlpsp
      361 tspfsslsqd qaatskatls stsgldlmse sgegeispqr evsrsqdqfs dmrisinqtp
      421 gksldfgfti kwdipgifva sveagspaef sqlqvddeii ainntkfsyn dskeweeama
      481 kaqetghlvm dvrrygkadw gkdqpslpfi rhktlnltsm atkiigspet kwidatsgiy
      541 nsekssnlsv ttdfseslqs snieskeing ihdesnafes kasesislkn lkrrsqffeq
      601 gssdsvvpdl pvptisapsr wvwdqeeerk rqerwqkeqd rllqekyqre qeklreewqr
      661 akqeaerens kyldeelmvl ssnsmslttr epslatweat wsegskssdr egtrageeer
      721 rqpqeevvhe dqgkkpqdql viererkweq qlqeeqeqkr lqaeaeeqkr paeeqkrqae
      781 ieretsvriy qyrrpvdsyd ipkteeassg flpgdrnksr sttelddyst nkngnnkyld
      841 qignmtssqr rskkeqvpsg aelerqqilq emrkrtplhn dnswirqrsa svnkepvslp
      901 gimrrgesld nldsprsnsw rqppwlnqpt gfyasssvqd fsrpppqlvs tsnraymrnp
      961 sssvpppsag svktsttgva ttqsptprsh spsasqsgsq lrnsvlpvsv tsealpqelk
     1021 sgsettncta ttaisdsnld gqppcdvslh tkallqieee vvaahvdl
//
LOCUS       XP_047286292            1068 aa            linear   PRI 05-AUG-2025
DEFINITION  LIM domain only protein 7 isoform X27 [Homo sapiens].
ACCESSION   XP_047286292
VERSION     XP_047286292.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430336.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1068
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1068
                     /product="LIM domain only protein 7 isoform X27"
                     /calculated_mol_wt=121302
     Region          9..158
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Site            order(423..424,427..431,440,443,475,479,482..483)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467153"
     Region          426..494
                     /region_name="PDZ"
                     /note="Domain present in PSD-95, Dlg, and ZO-1/2;
                     smart00228"
                     /db_xref="CDD:214570"
     Region          <612..668
                     /region_name="GBP_C"
                     /note="Guanylate-binding protein, C-terminal domain;
                     cd16269"
                     /db_xref="CDD:293879"
     Region          <615..>770
                     /region_name="DUF5401"
                     /note="Family of unknown function (DUF5401); pfam17380"
                     /db_xref="CDD:375164"
     Region          655..666
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:293879"
     Region          999..1057
                     /region_name="LIM"
                     /note="LIM is a small protein-protein interaction domain,
                     containing two zinc fingers; cd08368"
                     /db_xref="CDD:259829"
     Site            order(999,1002,1022,1025,1028,1031,1053,1056)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..1068
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /coded_by="XM_047430336.1:631..3837"
                     /db_xref="GeneID:4008"
                     /db_xref="HGNC:HGNC:6646"
                     /db_xref="MIM:604362"
ORIGIN      
        1 mqdynkddms yrrisavepk talpfnrflp nksrqpsyvp aplrkkkpdk hednrrswas
       61 pvyteadgtf srsksmsdvs aedvqnlrql ryeemqkiks qlkeqdqkwq ddlakwkdrr
      121 ksytsdlqkk keereeiekq alekskrssk tfkemlqdre sqnqkstvps rrrmysfddv
      181 leegkrpptm tvseasyqse rveekgatyp seipkedstt fakredrvtt eiqlpsqspv
      241 eeqspaslss lrsrstqmes trvsaslprs yrktdtvrlt svvtprpfgs qtrgisslpr
      301 sytmddawky ngdvedikrt pnnvvstpap spdasqlass lssqkevaat eedvtrlpsp
      361 tspfsslsqd qaatskatls stsgldlmse sgegeispqr evsrsqdqfs dmrisinqtp
      421 gksldfgfti kwdipgifva sveagspaef sqlqvddeii ainntkfsyn dskeweeama
      481 kaqetghlvm dvrrygkags petkwidats giynsekssn lsvttdfses lqssnieske
      541 ingihdesna feskasesis lknlkrrsqf feqgssgfsy sswvylcgss dsvvpdlpvp
      601 tisapsrwvw dqeeerkrqe rwqkeqdrll qekyqreqek lreewqrakq eaerenskyl
      661 deelmvlssn smslttreps latweatwse gskssdregt rageeerrqp qeevvhedqg
      721 kkpqdqlvie rerkweqqlq eeqeqkrlqa eaeeqkrpae eqkrqaeier etsvriyqyr
      781 rpvdsydipk teeassgflp gdrnksrstt elddystnkn gnnkyldqig nmtssqrrsk
      841 keqvpsgael erqqilqemr krtplhndns wirqrsasvn kepvslpgim rrgesldnld
      901 sprsnswrqp pwlnqptgfy asssvqdfsr pppqlvstsn raymrnpsss vpppsagsvk
      961 tsttgvattq sptprshsps asqsgsqlrn rsvsgkrics ycnnilgkga amiieslglc
     1021 yhlhcfkcva cecdlggsss gaevrirnhq lycndcylrf ksgrptam
//
LOCUS       XP_047286293            1051 aa            linear   PRI 05-AUG-2025
DEFINITION  LIM domain only protein 7 isoform X28 [Homo sapiens].
ACCESSION   XP_047286293
VERSION     XP_047286293.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430337.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1051
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1051
                     /product="LIM domain only protein 7 isoform X28"
                     /calculated_mol_wt=119108
     Region          9..168
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Site            order(433..434,437..441,450,453,485,489,492..493)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467153"
     Region          436..504
                     /region_name="PDZ"
                     /note="Domain present in PSD-95, Dlg, and ZO-1/2;
                     smart00228"
                     /db_xref="CDD:214570"
     Region          <608..664
                     /region_name="GBP_C"
                     /note="Guanylate-binding protein, C-terminal domain;
                     cd16269"
                     /db_xref="CDD:293879"
     Region          <611..>766
                     /region_name="DUF5401"
                     /note="Family of unknown function (DUF5401); pfam17380"
                     /db_xref="CDD:375164"
     Region          651..662
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:293879"
     CDS             1..1051
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /coded_by="XM_047430337.1:631..3786"
                     /db_xref="GeneID:4008"
                     /db_xref="HGNC:HGNC:6646"
                     /db_xref="MIM:604362"
ORIGIN      
        1 mqdynkddms yrrisavepk talpfnrflp nksrqpsyvp aplrkkkpdk hednrrswas
       61 pvyteadgtf srlfqkiyge ngsksmsdvs aedvqnlrql ryeemqkiks qlkeqdqkwq
      121 ddlakwkdrr ksytsdlqkk keereeiekq alekskrssk tfkemlqdre sqnqkstvps
      181 rrrmysfddv leegkrpptm tvseasyqse rveekgatyp seipkedstt fakredrvtt
      241 eiqlpsqspv eeqspaslss lrsrstqmes trvsaslprs yrktdtvrlt svvtprpfgs
      301 qtrgisslpr sytmddawky ngdvedikrt pnnvvstpap spdasqlass lssqkevaat
      361 eedvtrlpsp tspfsslsqd qaatskatls stsgldlmse sgegeispqr evsrsqdqfs
      421 dmrisinqtp gksldfgfti kwdipgifva sveagspaef sqlqvddeii ainntkfsyn
      481 dskeweeama kaqetghlvm dvrrygkags petkwidats giynsekssn lsvttdfses
      541 lqssnieske ingihdesna feskasesis lknlkrrsqf feqgssdsvv pdlpvptisa
      601 psrwvwdqee erkrqerwqk eqdrllqeky qreqeklree wqrakqeaer enskyldeel
      661 mvlssnsmsl ttrepslatw eatwsegsks sdregtrage eerrqpqeev vhedqgkkpq
      721 dqlviererk weqqlqeeqe qkrlqaeaee qkrpaeeqkr qaeieretsv riyqyrrpvd
      781 sydipkteea ssgflpgdrn ksrstteldd ystnkngnnk yldqignmts sqrrskkeqv
      841 psgaelerqq ilqemrkrtp lhndnswirq rsasvnkepv slpgimrrge sldnldsprs
      901 nswrqppwln qptgfyasss vqdfsrpppq lvstsnraym rnpsssvppp sagsvktstt
      961 gvattqsptp rshspsasqs gsqlrnsvlp vsvtsealpq elksgsettn ctattaisds
     1021 nldgqppcdv slhtkallqi eeevvaahvd l
//
LOCUS       XP_047286294            1045 aa            linear   PRI 05-AUG-2025
DEFINITION  LIM domain only protein 7 isoform X29 [Homo sapiens].
ACCESSION   XP_047286294
VERSION     XP_047286294.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430338.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1045
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1045
                     /product="LIM domain only protein 7 isoform X29"
                     /calculated_mol_wt=118677
     Region          9..168
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Site            order(433..434,437..441,450,453,485,489,492..493)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467153"
     Region          436..504
                     /region_name="PDZ"
                     /note="Domain present in PSD-95, Dlg, and ZO-1/2;
                     smart00228"
                     /db_xref="CDD:214570"
     Region          <589..645
                     /region_name="GBP_C"
                     /note="Guanylate-binding protein, C-terminal domain;
                     cd16269"
                     /db_xref="CDD:293879"
     Region          <592..>747
                     /region_name="DUF5401"
                     /note="Family of unknown function (DUF5401); pfam17380"
                     /db_xref="CDD:375164"
     Region          632..643
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:293879"
     Region          976..1034
                     /region_name="LIM"
                     /note="LIM is a small protein-protein interaction domain,
                     containing two zinc fingers; cd08368"
                     /db_xref="CDD:259829"
     Site            order(976,979,999,1002,1005,1008,1030,1033)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..1045
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /coded_by="XM_047430338.1:631..3768"
                     /db_xref="GeneID:4008"
                     /db_xref="HGNC:HGNC:6646"
                     /db_xref="MIM:604362"
ORIGIN      
        1 mqdynkddms yrrisavepk talpfnrflp nksrqpsyvp aplrkkkpdk hednrrswas
       61 pvyteadgtf srlfqkiyge ngsksmsdvs aedvqnlrql ryeemqkiks qlkeqdqkwq
      121 ddlakwkdrr ksytsdlqkk keereeiekq alekskrssk tfkemlqdre sqnqkstvps
      181 rrrmysfddv leegkrpptm tvseasyqse rveekgatyp seipkedstt fakredrvtt
      241 eiqlpsqspv eeqspaslss lrsrstqmes trvsaslprs yrktdtvrlt svvtprpfgs
      301 qtrgisslpr sytmddawky ngdvedikrt pnnvvstpap spdasqlass lssqkevaat
      361 eedvtrlpsp tspfsslsqd qaatskatls stsgldlmse sgegeispqr evsrsqdqfs
      421 dmrisinqtp gksldfgfti kwdipgifva sveagspaef sqlqvddeii ainntkfsyn
      481 dskeweeama kaqetghlvm dvrrygkags petkwidats giynsekssn lsvttdfses
      541 lqssnieske ingihdesna feskgssdsv vpdlpvptis apsrwvwdqe eerkrqerwq
      601 keqdrllqek yqreqeklre ewqrakqeae renskyldee lmvlssnsms lttrepslat
      661 weatwsegsk ssdregtrag eeerrqpqee vvhedqgkkp qdqlvierer kweqqlqeeq
      721 eqkrlqaeae eqkrpaeeqk rqaeierets vriyqyrrpv dsydipktee assgflpgdr
      781 nksrstteld dystnkngnn kyldqignmt ssqrrskkeq vpsgaelerq qilqemrkrt
      841 plhndnswir qrsasvnkep vslpgimrrg esldnldspr snswrqppwl nqptgfyass
      901 svqdfsrppp qlvstsnray mrnpsssvpp psagsvktst tgvattqspt prshspsasq
      961 sgsqlrnrsv sgkricsycn nilgkgaami ieslglcyhl hcfkcvacec dlggsssgae
     1021 vrirnhqlyc ndcylrfksg rptam
//
LOCUS       XP_047286295            1309 aa            linear   PRI 05-AUG-2025
DEFINITION  LIM domain only protein 7 isoform X30 [Homo sapiens].
ACCESSION   XP_047286295
VERSION     XP_047286295.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430339.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1309
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1309
                     /product="LIM domain only protein 7 isoform X30"
                     /calculated_mol_wt=149075
     Region          <42..100
                     /region_name="CH_SF"
                     /note="calponin homology (CH) domain superfamily; cl00030"
                     /db_xref="CDD:469584"
     Site            order(42,45..46,48,62..66,84,86..87,89..90,93..94,97)
                     /site_type="other"
                     /note="actin binding site [polypeptide binding]"
                     /db_xref="CDD:409031"
     Region          213..372
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Site            order(637..638,641..645,654,657,689,693,696..697)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467153"
     Region          640..708
                     /region_name="PDZ"
                     /note="Domain present in PSD-95, Dlg, and ZO-1/2;
                     smart00228"
                     /db_xref="CDD:214570"
     Region          <856..>1104
                     /region_name="DUF5401"
                     /note="Family of unknown function (DUF5401); pfam17380"
                     /db_xref="CDD:375164"
     Region          1240..1298
                     /region_name="LIM"
                     /note="LIM is a small protein-protein interaction domain,
                     containing two zinc fingers; cd08368"
                     /db_xref="CDD:259829"
     Site            order(1240,1243,1263,1266,1269,1272,1294,1297)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..1309
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /coded_by="XM_047430339.1:14..3943"
                     /db_xref="GeneID:4008"
                     /db_xref="HGNC:HGNC:6646"
                     /db_xref="MIM:604362"
ORIGIN      
        1 mpghkiarlc mlwrterlyk pyvfffkyty awvlllplll tdninvflka ceqiglkeaq
       61 lfhpgdlqdl snrvtvkqee tdrrvknvli tlywlgrkaq snpyyngphl nlkafenllg
      121 qaltkaleds sflkrsgrds gygdiwcper geflapprhh kredsfesld slgsrsltsc
      181 ssditlrggr egfesdtdse ftfkmqdynk ddmsyrrisa vepktalpfn rflpnksrqp
      241 syvpaplrkk kpdkhednrr swaspvytea dgtfsrlfqk iygengsksm sdvsaedvqn
      301 lrqlryeemq kiksqlkeqd qkwqddlakw kdrrksytsd lqkkkeeree iekqaleksk
      361 rssktfkeml qdresqnqks tvpsrrrmys fddvleegkr pptmtvseas yqserveekg
      421 atypseipke dsttfakred rvtteiqlps qspveeqspa slsslrsrst qmestrvsas
      481 lprsyrktdt vrltsvvtpr pfgsqtrgis slprsytmdd awkyngdved ikrtpnnvvs
      541 tpapspdasq lasslssqke vaateedvtr lpsptspfss lsqdqaatsk atlsstsgld
      601 lmsesgegei spqrevsrsq dqfsdmrisi nqtpgksldf gftikwdipg ifvasveags
      661 paefsqlqvd deiiainntk fsyndskewe eamakaqetg hlvmdvrryg kadwgkdqps
      721 lpfirhktln ltsmatkiig spetkwidat sgiynsekss nlsvttdfse slqssniesk
      781 eingihdesn afeskasesi slknlkrrsq ffeqgssgfs ysswvylcgs sdsvvpdlpv
      841 ptisapsrwv wdqeeerkrq erwqkeqdrl lqekyqreqe klreewqrak qeaerensky
      901 ldeelmvlss nsmslttrep slatweatws egskssdreg trageeerrq pqeevvhedq
      961 gkkpqdqlvi ererkweqql qeeqeqkrlq aeaeeqkrpa eeqkrqaeie retsvriyqy
     1021 rrpvdsydip kteeassgfl pgdrnksrst telddystnk ngnnkyldqi gnmtssqrrs
     1081 kkeqvpsgae lerqqilqem rkrtplhndn swirqrsasv nkepvslpgi mrrgesldnl
     1141 dsprsnswrq ppwlnqptgf yasssvqdfs rpppqlvsts nraymrnpss svpppsagsv
     1201 ktsttgvatt qsptprshsp sasqsgsqlr nrsvsgkric sycnnilgkg aamiieslgl
     1261 cyhlhcfkcv acecdlggss sgaevrirnh qlycndcylr fksgrptam
//
LOCUS       XP_047286296            1041 aa            linear   PRI 05-AUG-2025
DEFINITION  LIM domain only protein 7 isoform X31 [Homo sapiens].
ACCESSION   XP_047286296
VERSION     XP_047286296.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430340.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1041
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1041
                     /product="LIM domain only protein 7 isoform X31"
                     /calculated_mol_wt=117958
     Region          9..158
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Site            order(423..424,427..431,440,443,475,479,482..483)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467153"
     Region          426..494
                     /region_name="PDZ"
                     /note="Domain present in PSD-95, Dlg, and ZO-1/2;
                     smart00228"
                     /db_xref="CDD:214570"
     Region          <598..654
                     /region_name="GBP_C"
                     /note="Guanylate-binding protein, C-terminal domain;
                     cd16269"
                     /db_xref="CDD:293879"
     Region          <601..>756
                     /region_name="DUF5401"
                     /note="Family of unknown function (DUF5401); pfam17380"
                     /db_xref="CDD:375164"
     Region          641..652
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:293879"
     CDS             1..1041
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /coded_by="XM_047430340.1:631..3756"
                     /db_xref="GeneID:4008"
                     /db_xref="HGNC:HGNC:6646"
                     /db_xref="MIM:604362"
ORIGIN      
        1 mqdynkddms yrrisavepk talpfnrflp nksrqpsyvp aplrkkkpdk hednrrswas
       61 pvyteadgtf srsksmsdvs aedvqnlrql ryeemqkiks qlkeqdqkwq ddlakwkdrr
      121 ksytsdlqkk keereeiekq alekskrssk tfkemlqdre sqnqkstvps rrrmysfddv
      181 leegkrpptm tvseasyqse rveekgatyp seipkedstt fakredrvtt eiqlpsqspv
      241 eeqspaslss lrsrstqmes trvsaslprs yrktdtvrlt svvtprpfgs qtrgisslpr
      301 sytmddawky ngdvedikrt pnnvvstpap spdasqlass lssqkevaat eedvtrlpsp
      361 tspfsslsqd qaatskatls stsgldlmse sgegeispqr evsrsqdqfs dmrisinqtp
      421 gksldfgfti kwdipgifva sveagspaef sqlqvddeii ainntkfsyn dskeweeama
      481 kaqetghlvm dvrrygkags petkwidats giynsekssn lsvttdfses lqssnieske
      541 ingihdesna feskasesis lknlkrrsqf feqgssdsvv pdlpvptisa psrwvwdqee
      601 erkrqerwqk eqdrllqeky qreqeklree wqrakqeaer enskyldeel mvlssnsmsl
      661 ttrepslatw eatwsegsks sdregtrage eerrqpqeev vhedqgkkpq dqlviererk
      721 weqqlqeeqe qkrlqaeaee qkrpaeeqkr qaeieretsv riyqyrrpvd sydipkteea
      781 ssgflpgdrn ksrstteldd ystnkngnnk yldqignmts sqrrskkeqv psgaelerqq
      841 ilqemrkrtp lhndnswirq rsasvnkepv slpgimrrge sldnldsprs nswrqppwln
      901 qptgfyasss vqdfsrpppq lvstsnraym rnpsssvppp sagsvktstt gvattqsptp
      961 rshspsasqs gsqlrnsvlp vsvtsealpq elksgsettn ctattaisds nldgqppcdv
     1021 slhtkallqi eeevvaahvd l
//
LOCUS       XP_047286297            1296 aa            linear   PRI 05-AUG-2025
DEFINITION  LIM domain only protein 7 isoform X32 [Homo sapiens].
ACCESSION   XP_047286297
VERSION     XP_047286297.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430341.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1296
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1296
                     /product="LIM domain only protein 7 isoform X32"
                     /calculated_mol_wt=147267
     Region          <29..87
                     /region_name="CH_SF"
                     /note="calponin homology (CH) domain superfamily; cl00030"
                     /db_xref="CDD:469584"
     Site            order(29,32..33,35,49..53,71,73..74,76..77,80..81,84)
                     /site_type="other"
                     /note="actin binding site [polypeptide binding]"
                     /db_xref="CDD:409031"
     Region          200..359
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Site            order(624..625,628..632,641,644,676,680,683..684)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467153"
     Region          627..695
                     /region_name="PDZ"
                     /note="Domain present in PSD-95, Dlg, and ZO-1/2;
                     smart00228"
                     /db_xref="CDD:214570"
     Region          <843..>1091
                     /region_name="DUF5401"
                     /note="Family of unknown function (DUF5401); pfam17380"
                     /db_xref="CDD:375164"
     Region          1227..1285
                     /region_name="LIM"
                     /note="LIM is a small protein-protein interaction domain,
                     containing two zinc fingers; cd08368"
                     /db_xref="CDD:259829"
     Site            order(1227,1230,1250,1253,1256,1259,1281,1284)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..1296
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /coded_by="XM_047430341.1:27..3917"
                     /db_xref="GeneID:4008"
                     /db_xref="HGNC:HGNC:6646"
                     /db_xref="MIM:604362"
ORIGIN      
        1 mntrfllspi vwfpclsras sttkprfqdn invflkaceq iglkeaqlfh pgdlqdlsnr
       61 vtvkqeetdr rvknvlitly wlgrkaqsnp yyngphlnlk afenllgqal tkaledssfl
      121 krsgrdsgyg diwcpergef lapprhhkre dsfesldslg srsltscssd itlrggregf
      181 esdtdseftf kmqdynkddm syrrisavep ktalpfnrfl pnksrqpsyv paplrkkkpd
      241 khednrrswa spvyteadgt fsrlfqkiyg engsksmsdv saedvqnlrq lryeemqkik
      301 sqlkeqdqkw qddlakwkdr rksytsdlqk kkeereeiek qalekskrss ktfkemlqdr
      361 esqnqkstvp srrrmysfdd vleegkrppt mtvseasyqs erveekgaty pseipkedst
      421 tfakredrvt teiqlpsqsp veeqspasls slrsrstqme strvsaslpr syrktdtvrl
      481 tsvvtprpfg sqtrgisslp rsytmddawk yngdvedikr tpnnvvstpa pspdasqlas
      541 slssqkevaa teedvtrlps ptspfsslsq dqaatskatl sstsgldlms esgegeispq
      601 revsrsqdqf sdmrisinqt pgksldfgft ikwdipgifv asveagspae fsqlqvddei
      661 iainntkfsy ndskeweeam akaqetghlv mdvrrygkad wgkdqpslpf irhktlnlts
      721 matkiigspe tkwidatsgi ynsekssnls vttdfseslq ssnieskein gihdesnafe
      781 skasesislk nlkrrsqffe qgssgfsyss wvylcgssds vvpdlpvpti sapsrwvwdq
      841 eeerkrqerw qkeqdrllqe kyqreqeklr eewqrakqea erenskylde elmvlssnsm
      901 slttrepsla tweatwsegs kssdregtra geeerrqpqe evvhedqgkk pqdqlviere
      961 rkweqqlqee qeqkrlqaea eeqkrpaeeq krqaeieret svriyqyrrp vdsydipkte
     1021 eassgflpgd rnksrsttel ddystnkngn nkyldqignm tssqrrskke qvpsgaeler
     1081 qqilqemrkr tplhndnswi rqrsasvnke pvslpgimrr gesldnldsp rsnswrqppw
     1141 lnqptgfyas ssvqdfsrpp pqlvstsnra ymrnpsssvp ppsagsvkts ttgvattqsp
     1201 tprshspsas qsgsqlrnrs vsgkricsyc nnilgkgaam iieslglcyh lhcfkcvace
     1261 cdlggsssga evrirnhqly cndcylrfks grptam
//
LOCUS       XP_047286298            1295 aa            linear   PRI 05-AUG-2025
DEFINITION  LIM domain only protein 7 isoform X33 [Homo sapiens].
ACCESSION   XP_047286298
VERSION     XP_047286298.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430342.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1295
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1295
                     /product="LIM domain only protein 7 isoform X33"
                     /calculated_mol_wt=147551
     Region          <42..100
                     /region_name="CH_SF"
                     /note="calponin homology (CH) domain superfamily; cl00030"
                     /db_xref="CDD:469584"
     Site            order(42,45..46,48,62..66,84,86..87,89..90,93..94,97)
                     /site_type="other"
                     /note="actin binding site [polypeptide binding]"
                     /db_xref="CDD:409031"
     Region          213..372
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Site            order(637..638,641..645,654,657,689,693,696..697)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467153"
     Region          640..708
                     /region_name="PDZ"
                     /note="Domain present in PSD-95, Dlg, and ZO-1/2;
                     smart00228"
                     /db_xref="CDD:214570"
     Region          <842..>1123
                     /region_name="DUF5401"
                     /note="Family of unknown function (DUF5401); pfam17380"
                     /db_xref="CDD:375164"
     Region          1226..1284
                     /region_name="LIM"
                     /note="LIM is a small protein-protein interaction domain,
                     containing two zinc fingers; cd08368"
                     /db_xref="CDD:259829"
     Site            order(1226,1229,1249,1252,1255,1258,1280,1283)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..1295
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /coded_by="XM_047430342.1:14..3901"
                     /db_xref="GeneID:4008"
                     /db_xref="HGNC:HGNC:6646"
                     /db_xref="MIM:604362"
ORIGIN      
        1 mpghkiarlc mlwrterlyk pyvfffkyty awvlllplll tdninvflka ceqiglkeaq
       61 lfhpgdlqdl snrvtvkqee tdrrvknvli tlywlgrkaq snpyyngphl nlkafenllg
      121 qaltkaleds sflkrsgrds gygdiwcper geflapprhh kredsfesld slgsrsltsc
      181 ssditlrggr egfesdtdse ftfkmqdynk ddmsyrrisa vepktalpfn rflpnksrqp
      241 syvpaplrkk kpdkhednrr swaspvytea dgtfsrlfqk iygengsksm sdvsaedvqn
      301 lrqlryeemq kiksqlkeqd qkwqddlakw kdrrksytsd lqkkkeeree iekqaleksk
      361 rssktfkeml qdresqnqks tvpsrrrmys fddvleegkr pptmtvseas yqserveekg
      421 atypseipke dsttfakred rvtteiqlps qspveeqspa slsslrsrst qmestrvsas
      481 lprsyrktdt vrltsvvtpr pfgsqtrgis slprsytmdd awkyngdved ikrtpnnvvs
      541 tpapspdasq lasslssqke vaateedvtr lpsptspfss lsqdqaatsk atlsstsgld
      601 lmsesgegei spqrevsrsq dqfsdmrisi nqtpgksldf gftikwdipg ifvasveags
      661 paefsqlqvd deiiainntk fsyndskewe eamakaqetg hlvmdvrryg kadwgkdqps
      721 lpfirhktln ltsmatkiig spetkwidat sgiynsekss nlsvttdfse slqssniesk
      781 eingihdesn afeskasesi slknlkrrsq ffeqgssdsv vpdlpvptis apsrwvwdqe
      841 eerkrqerwq keqdrllqek yqreqeklre ewqrakqeae renskyldee lmvlssnsms
      901 lttrepslat weatwsegsk ssdregtrag eeerrqpqee vvhedqgkkp qdqlvierer
      961 kweqqlqeeq eqkrlqaeae eqkrpaeeqk rqaeierets vriyqyrrpv dsydipktee
     1021 assgflpgdr nksrstteld dystnkngnn kyldqignmt ssqrrskkeq vpsgaelerq
     1081 qilqemrkrt plhndnswir qrsasvnkep vslpgimrrg esldnldspr snswrqppwl
     1141 nqptgfyass svqdfsrppp qlvstsnray mrnpsssvpp psagsvktst tgvattqspt
     1201 prshspsasq sgsqlrnrsv sgkricsycn nilgkgaami ieslglcyhl hcfkcvacec
     1261 dlggsssgae vrirnhqlyc ndcylrfksg rptam
//
LOCUS       XP_047286299            1022 aa            linear   PRI 05-AUG-2025
DEFINITION  LIM domain only protein 7 isoform X34 [Homo sapiens].
ACCESSION   XP_047286299
VERSION     XP_047286299.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430343.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1022
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1022
                     /product="LIM domain only protein 7 isoform X34"
                     /calculated_mol_wt=115708
     Region          9..158
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Site            order(423..424,427..431,440,443,475,479,482..483)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467153"
     Region          426..494
                     /region_name="PDZ"
                     /note="Domain present in PSD-95, Dlg, and ZO-1/2;
                     smart00228"
                     /db_xref="CDD:214570"
     Region          <579..635
                     /region_name="GBP_C"
                     /note="Guanylate-binding protein, C-terminal domain;
                     cd16269"
                     /db_xref="CDD:293879"
     Region          <582..>737
                     /region_name="DUF5401"
                     /note="Family of unknown function (DUF5401); pfam17380"
                     /db_xref="CDD:375164"
     Region          622..633
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:293879"
     CDS             1..1022
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /coded_by="XM_047430343.1:631..3699"
                     /db_xref="GeneID:4008"
                     /db_xref="HGNC:HGNC:6646"
                     /db_xref="MIM:604362"
ORIGIN      
        1 mqdynkddms yrrisavepk talpfnrflp nksrqpsyvp aplrkkkpdk hednrrswas
       61 pvyteadgtf srsksmsdvs aedvqnlrql ryeemqkiks qlkeqdqkwq ddlakwkdrr
      121 ksytsdlqkk keereeiekq alekskrssk tfkemlqdre sqnqkstvps rrrmysfddv
      181 leegkrpptm tvseasyqse rveekgatyp seipkedstt fakredrvtt eiqlpsqspv
      241 eeqspaslss lrsrstqmes trvsaslprs yrktdtvrlt svvtprpfgs qtrgisslpr
      301 sytmddawky ngdvedikrt pnnvvstpap spdasqlass lssqkevaat eedvtrlpsp
      361 tspfsslsqd qaatskatls stsgldlmse sgegeispqr evsrsqdqfs dmrisinqtp
      421 gksldfgfti kwdipgifva sveagspaef sqlqvddeii ainntkfsyn dskeweeama
      481 kaqetghlvm dvrrygkags petkwidats giynsekssn lsvttdfses lqssnieske
      541 ingihdesna feskgssdsv vpdlpvptis apsrwvwdqe eerkrqerwq keqdrllqek
      601 yqreqeklre ewqrakqeae renskyldee lmvlssnsms lttrepslat weatwsegsk
      661 ssdregtrag eeerrqpqee vvhedqgkkp qdqlvierer kweqqlqeeq eqkrlqaeae
      721 eqkrpaeeqk rqaeierets vriyqyrrpv dsydipktee assgflpgdr nksrstteld
      781 dystnkngnn kyldqignmt ssqrrskkeq vpsgaelerq qilqemrkrt plhndnswir
      841 qrsasvnkep vslpgimrrg esldnldspr snswrqppwl nqptgfyass svqdfsrppp
      901 qlvstsnray mrnpsssvpp psagsvktst tgvattqspt prshspsasq sgsqlrnsvl
      961 pvsvtsealp qelksgsett nctattaisd snldgqppcd vslhtkallq ieeevvaahv
     1021 dl
//
LOCUS       XP_047286300            1286 aa            linear   PRI 05-AUG-2025
DEFINITION  LIM domain only protein 7 isoform X35 [Homo sapiens].
ACCESSION   XP_047286300
VERSION     XP_047286300.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430344.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1286
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1286
                     /product="LIM domain only protein 7 isoform X35"
                     /calculated_mol_wt=146117
     Region          <29..87
                     /region_name="CH_SF"
                     /note="calponin homology (CH) domain superfamily; cl00030"
                     /db_xref="CDD:469584"
     Site            order(29,32..33,35,49..53,71,73..74,76..77,80..81,84)
                     /site_type="other"
                     /note="actin binding site [polypeptide binding]"
                     /db_xref="CDD:409031"
     Region          200..349
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Site            order(614..615,618..622,631,634,666,670,673..674)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467153"
     Region          617..685
                     /region_name="PDZ"
                     /note="Domain present in PSD-95, Dlg, and ZO-1/2;
                     smart00228"
                     /db_xref="CDD:214570"
     Region          <833..>1114
                     /region_name="DUF5401"
                     /note="Family of unknown function (DUF5401); pfam17380"
                     /db_xref="CDD:375164"
     Region          1217..1275
                     /region_name="LIM"
                     /note="LIM is a small protein-protein interaction domain,
                     containing two zinc fingers; cd08368"
                     /db_xref="CDD:259829"
     Site            order(1217,1220,1240,1243,1246,1249,1271,1274)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..1286
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /coded_by="XM_047430344.1:27..3887"
                     /db_xref="GeneID:4008"
                     /db_xref="HGNC:HGNC:6646"
                     /db_xref="MIM:604362"
ORIGIN      
        1 mntrfllspi vwfpclsras sttkprfqdn invflkaceq iglkeaqlfh pgdlqdlsnr
       61 vtvkqeetdr rvknvlitly wlgrkaqsnp yyngphlnlk afenllgqal tkaledssfl
      121 krsgrdsgyg diwcpergef lapprhhkre dsfesldslg srsltscssd itlrggregf
      181 esdtdseftf kmqdynkddm syrrisavep ktalpfnrfl pnksrqpsyv paplrkkkpd
      241 khednrrswa spvyteadgt fsrsksmsdv saedvqnlrq lryeemqkik sqlkeqdqkw
      301 qddlakwkdr rksytsdlqk kkeereeiek qalekskrss ktfkemlqdr esqnqkstvp
      361 srrrmysfdd vleegkrppt mtvseasyqs erveekgaty pseipkedst tfakredrvt
      421 teiqlpsqsp veeqspasls slrsrstqme strvsaslpr syrktdtvrl tsvvtprpfg
      481 sqtrgisslp rsytmddawk yngdvedikr tpnnvvstpa pspdasqlas slssqkevaa
      541 teedvtrlps ptspfsslsq dqaatskatl sstsgldlms esgegeispq revsrsqdqf
      601 sdmrisinqt pgksldfgft ikwdipgifv asveagspae fsqlqvddei iainntkfsy
      661 ndskeweeam akaqetghlv mdvrrygkad wgkdqpslpf irhktlnlts matkiigspe
      721 tkwidatsgi ynsekssnls vttdfseslq ssnieskein gihdesnafe skasesislk
      781 nlkrrsqffe qgssgfsyss wvylcgssds vvpdlpvpti sapsrwvwdq eeerkrqerw
      841 qkeqdrllqe kyqreqeklr eewqrakqea erenskylde elmvlssnsm slttrepsla
      901 tweatwsegs kssdregtra geeerrqpqe evvhedqgkk pqdqlviere rkweqqlqee
      961 qeqkrlqaea eeqkrpaeeq krqaeieret svriyqyrrp vdsydipkte eassgflpgd
     1021 rnksrsttel ddystnkngn nkyldqignm tssqrrskke qvpsgaeler qqilqemrkr
     1081 tplhndnswi rqrsasvnke pvslpgimrr gesldnldsp rsnswrqppw lnqptgfyas
     1141 ssvqdfsrpp pqlvstsnra ymrnpsssvp ppsagsvkts ttgvattqsp tprshspsas
     1201 qsgsqlrnrs vsgkricsyc nnilgkgaam iieslglcyh lhcfkcvace cdlggsssga
     1261 evrirnhqly cndcylrfks grptam
//
LOCUS       XP_024305131            1285 aa            linear   PRI 05-AUG-2025
DEFINITION  LIM domain only protein 7 isoform X36 [Homo sapiens].
ACCESSION   XP_024305131
VERSION     XP_024305131.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449363.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XP_024305131.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1285
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1285
                     /product="LIM domain only protein 7 isoform X36"
                     /calculated_mol_wt=146400
     Region          <42..100
                     /region_name="CH_SF"
                     /note="calponin homology (CH) domain superfamily; cl00030"
                     /db_xref="CDD:469584"
     Site            order(42,45..46,48,62..66,84,86..87,89..90,93..94,97)
                     /site_type="other"
                     /note="actin binding site [polypeptide binding]"
                     /db_xref="CDD:409031"
     Region          213..362
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Site            order(627..628,631..635,644,647,679,683,686..687)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467223"
     Region          630..698
                     /region_name="PDZ"
                     /note="Domain present in PSD-95, Dlg, and ZO-1/2;
                     smart00228"
                     /db_xref="CDD:214570"
     Region          <832..>1113
                     /region_name="DUF5401"
                     /note="Family of unknown function (DUF5401); pfam17380"
                     /db_xref="CDD:375164"
     Region          1216..1274
                     /region_name="LIM"
                     /note="LIM is a small protein-protein interaction domain,
                     containing two zinc fingers; cd08368"
                     /db_xref="CDD:259829"
     Site            order(1216,1219,1239,1242,1245,1248,1270,1273)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..1285
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /coded_by="XM_024449363.2:14..3871"
                     /db_xref="GeneID:4008"
                     /db_xref="HGNC:HGNC:6646"
                     /db_xref="MIM:604362"
ORIGIN      
        1 mpghkiarlc mlwrterlyk pyvfffkyty awvlllplll tdninvflka ceqiglkeaq
       61 lfhpgdlqdl snrvtvkqee tdrrvknvli tlywlgrkaq snpyyngphl nlkafenllg
      121 qaltkaleds sflkrsgrds gygdiwcper geflapprhh kredsfesld slgsrsltsc
      181 ssditlrggr egfesdtdse ftfkmqdynk ddmsyrrisa vepktalpfn rflpnksrqp
      241 syvpaplrkk kpdkhednrr swaspvytea dgtfsrsksm sdvsaedvqn lrqlryeemq
      301 kiksqlkeqd qkwqddlakw kdrrksytsd lqkkkeeree iekqaleksk rssktfkeml
      361 qdresqnqks tvpsrrrmys fddvleegkr pptmtvseas yqserveekg atypseipke
      421 dsttfakred rvtteiqlps qspveeqspa slsslrsrst qmestrvsas lprsyrktdt
      481 vrltsvvtpr pfgsqtrgis slprsytmdd awkyngdved ikrtpnnvvs tpapspdasq
      541 lasslssqke vaateedvtr lpsptspfss lsqdqaatsk atlsstsgld lmsesgegei
      601 spqrevsrsq dqfsdmrisi nqtpgksldf gftikwdipg ifvasveags paefsqlqvd
      661 deiiainntk fsyndskewe eamakaqetg hlvmdvrryg kadwgkdqps lpfirhktln
      721 ltsmatkiig spetkwidat sgiynsekss nlsvttdfse slqssniesk eingihdesn
      781 afeskasesi slknlkrrsq ffeqgssdsv vpdlpvptis apsrwvwdqe eerkrqerwq
      841 keqdrllqek yqreqeklre ewqrakqeae renskyldee lmvlssnsms lttrepslat
      901 weatwsegsk ssdregtrag eeerrqpqee vvhedqgkkp qdqlvierer kweqqlqeeq
      961 eqkrlqaeae eqkrpaeeqk rqaeierets vriyqyrrpv dsydipktee assgflpgdr
     1021 nksrstteld dystnkngnn kyldqignmt ssqrrskkeq vpsgaelerq qilqemrkrt
     1081 plhndnswir qrsasvnkep vslpgimrrg esldnldspr snswrqppwl nqptgfyass
     1141 svqdfsrppp qlvstsnray mrnpsssvpp psagsvktst tgvattqspt prshspsasq
     1201 sgsqlrnrsv sgkricsycn nilgkgaami ieslglcyhl hcfkcvacec dlggsssgae
     1261 vrirnhqlyc ndcylrfksg rptam
//
LOCUS       XP_047286301            1282 aa            linear   PRI 05-AUG-2025
DEFINITION  LIM domain only protein 7 isoform X37 [Homo sapiens].
ACCESSION   XP_047286301
VERSION     XP_047286301.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430345.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1282
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1282
                     /product="LIM domain only protein 7 isoform X37"
                     /calculated_mol_wt=145742
     Region          <29..87
                     /region_name="CH_SF"
                     /note="calponin homology (CH) domain superfamily; cl00030"
                     /db_xref="CDD:469584"
     Site            order(29,32..33,35,49..53,71,73..74,76..77,80..81,84)
                     /site_type="other"
                     /note="actin binding site [polypeptide binding]"
                     /db_xref="CDD:409031"
     Region          200..359
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Site            order(624..625,628..632,641,644,676,680,683..684)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467153"
     Region          627..695
                     /region_name="PDZ"
                     /note="Domain present in PSD-95, Dlg, and ZO-1/2;
                     smart00228"
                     /db_xref="CDD:214570"
     Region          <829..>1110
                     /region_name="DUF5401"
                     /note="Family of unknown function (DUF5401); pfam17380"
                     /db_xref="CDD:375164"
     Region          1213..1271
                     /region_name="LIM"
                     /note="LIM is a small protein-protein interaction domain,
                     containing two zinc fingers; cd08368"
                     /db_xref="CDD:259829"
     Site            order(1213,1216,1236,1239,1242,1245,1267,1270)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..1282
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /coded_by="XM_047430345.1:27..3875"
                     /db_xref="GeneID:4008"
                     /db_xref="HGNC:HGNC:6646"
                     /db_xref="MIM:604362"
ORIGIN      
        1 mntrfllspi vwfpclsras sttkprfqdn invflkaceq iglkeaqlfh pgdlqdlsnr
       61 vtvkqeetdr rvknvlitly wlgrkaqsnp yyngphlnlk afenllgqal tkaledssfl
      121 krsgrdsgyg diwcpergef lapprhhkre dsfesldslg srsltscssd itlrggregf
      181 esdtdseftf kmqdynkddm syrrisavep ktalpfnrfl pnksrqpsyv paplrkkkpd
      241 khednrrswa spvyteadgt fsrlfqkiyg engsksmsdv saedvqnlrq lryeemqkik
      301 sqlkeqdqkw qddlakwkdr rksytsdlqk kkeereeiek qalekskrss ktfkemlqdr
      361 esqnqkstvp srrrmysfdd vleegkrppt mtvseasyqs erveekgaty pseipkedst
      421 tfakredrvt teiqlpsqsp veeqspasls slrsrstqme strvsaslpr syrktdtvrl
      481 tsvvtprpfg sqtrgisslp rsytmddawk yngdvedikr tpnnvvstpa pspdasqlas
      541 slssqkevaa teedvtrlps ptspfsslsq dqaatskatl sstsgldlms esgegeispq
      601 revsrsqdqf sdmrisinqt pgksldfgft ikwdipgifv asveagspae fsqlqvddei
      661 iainntkfsy ndskeweeam akaqetghlv mdvrrygkad wgkdqpslpf irhktlnlts
      721 matkiigspe tkwidatsgi ynsekssnls vttdfseslq ssnieskein gihdesnafe
      781 skasesislk nlkrrsqffe qgssdsvvpd lpvptisaps rwvwdqeeer krqerwqkeq
      841 drllqekyqr eqeklreewq rakqeaeren skyldeelmv lssnsmsltt repslatwea
      901 twsegskssd regtrageee rrqpqeevvh edqgkkpqdq lviererkwe qqlqeeqeqk
      961 rlqaeaeeqk rpaeeqkrqa eieretsvri yqyrrpvdsy dipkteeass gflpgdrnks
     1021 rsttelddys tnkngnnkyl dqignmtssq rrskkeqvps gaelerqqil qemrkrtplh
     1081 ndnswirqrs asvnkepvsl pgimrrgesl dnldsprsns wrqppwlnqp tgfyasssvq
     1141 dfsrpppqlv stsnraymrn psssvpppsa gsvktsttgv attqsptprs hspsasqsgs
     1201 qlrnrsvsgk ricsycnnil gkgaamiies lglcyhlhcf kcvacecdlg gsssgaevri
     1261 rnhqlycndc ylrfksgrpt am
//
LOCUS       XP_047286302            1282 aa            linear   PRI 05-AUG-2025
DEFINITION  LIM domain only protein 7 isoform X38 [Homo sapiens].
ACCESSION   XP_047286302
VERSION     XP_047286302.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430346.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1282
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1282
                     /product="LIM domain only protein 7 isoform X38"
                     /calculated_mol_wt=145982
     Region          <42..100
                     /region_name="CH_SF"
                     /note="calponin homology (CH) domain superfamily; cl00030"
                     /db_xref="CDD:469584"
     Site            order(42,45..46,48,62..66,84,86..87,89..90,93..94,97)
                     /site_type="other"
                     /note="actin binding site [polypeptide binding]"
                     /db_xref="CDD:409031"
     Region          213..372
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Site            order(637..638,641..645,654,657,689,693,696..697)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467153"
     Region          640..708
                     /region_name="PDZ"
                     /note="Domain present in PSD-95, Dlg, and ZO-1/2;
                     smart00228"
                     /db_xref="CDD:214570"
     Region          <829..>1110
                     /region_name="DUF5401"
                     /note="Family of unknown function (DUF5401); pfam17380"
                     /db_xref="CDD:375164"
     Region          1213..1271
                     /region_name="LIM"
                     /note="LIM is a small protein-protein interaction domain,
                     containing two zinc fingers; cd08368"
                     /db_xref="CDD:259829"
     Site            order(1213,1216,1236,1239,1242,1245,1267,1270)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..1282
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /coded_by="XM_047430346.1:14..3862"
                     /db_xref="GeneID:4008"
                     /db_xref="HGNC:HGNC:6646"
                     /db_xref="MIM:604362"
ORIGIN      
        1 mpghkiarlc mlwrterlyk pyvfffkyty awvlllplll tdninvflka ceqiglkeaq
       61 lfhpgdlqdl snrvtvkqee tdrrvknvli tlywlgrkaq snpyyngphl nlkafenllg
      121 qaltkaleds sflkrsgrds gygdiwcper geflapprhh kredsfesld slgsrsltsc
      181 ssditlrggr egfesdtdse ftfkmqdynk ddmsyrrisa vepktalpfn rflpnksrqp
      241 syvpaplrkk kpdkhednrr swaspvytea dgtfsrlfqk iygengsksm sdvsaedvqn
      301 lrqlryeemq kiksqlkeqd qkwqddlakw kdrrksytsd lqkkkeeree iekqaleksk
      361 rssktfkeml qdresqnqks tvpsrrrmys fddvleegkr pptmtvseas yqserveekg
      421 atypseipke dsttfakred rvtteiqlps qspveeqspa slsslrsrst qmestrvsas
      481 lprsyrktdt vrltsvvtpr pfgsqtrgis slprsytmdd awkyngdved ikrtpnnvvs
      541 tpapspdasq lasslssqke vaateedvtr lpsptspfss lsqdqaatsk atlsstsgld
      601 lmsesgegei spqrevsrsq dqfsdmrisi nqtpgksldf gftikwdipg ifvasveags
      661 paefsqlqvd deiiainntk fsyndskewe eamakaqetg hlvmdvrryg kagspetkwi
      721 datsgiynse kssnlsvttd fseslqssni eskeingihd esnafeskas esislknlkr
      781 rsqffeqgss gfsysswvyl cgssdsvvpd lpvptisaps rwvwdqeeer krqerwqkeq
      841 drllqekyqr eqeklreewq rakqeaeren skyldeelmv lssnsmsltt repslatwea
      901 twsegskssd regtrageee rrqpqeevvh edqgkkpqdq lviererkwe qqlqeeqeqk
      961 rlqaeaeeqk rpaeeqkrqa eieretsvri yqyrrpvdsy dipkteeass gflpgdrnks
     1021 rsttelddys tnkngnnkyl dqignmtssq rrskkeqvps gaelerqqil qemrkrtplh
     1081 ndnswirqrs asvnkepvsl pgimrrgesl dnldsprsns wrqppwlnqp tgfyasssvq
     1141 dfsrpppqlv stsnraymrn psssvpppsa gsvktsttgv attqsptprs hspsasqsgs
     1201 qlrnrsvsgk ricsycnnil gkgaamiies lglcyhlhcf kcvacecdlg gsssgaevri
     1261 rnhqlycndc ylrfksgrpt am
//
LOCUS       XP_047286303            1269 aa            linear   PRI 05-AUG-2025
DEFINITION  LIM domain only protein 7 isoform X39 [Homo sapiens].
ACCESSION   XP_047286303
VERSION     XP_047286303.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430347.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1269
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1269
                     /product="LIM domain only protein 7 isoform X39"
                     /calculated_mol_wt=144173
     Region          <29..87
                     /region_name="CH_SF"
                     /note="calponin homology (CH) domain superfamily; cl00030"
                     /db_xref="CDD:469584"
     Site            order(29,32..33,35,49..53,71,73..74,76..77,80..81,84)
                     /site_type="other"
                     /note="actin binding site [polypeptide binding]"
                     /db_xref="CDD:409031"
     Region          200..359
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Site            order(624..625,628..632,641,644,676,680,683..684)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467153"
     Region          627..695
                     /region_name="PDZ"
                     /note="Domain present in PSD-95, Dlg, and ZO-1/2;
                     smart00228"
                     /db_xref="CDD:214570"
     Region          <816..>1097
                     /region_name="DUF5401"
                     /note="Family of unknown function (DUF5401); pfam17380"
                     /db_xref="CDD:375164"
     Region          1200..1258
                     /region_name="LIM"
                     /note="LIM is a small protein-protein interaction domain,
                     containing two zinc fingers; cd08368"
                     /db_xref="CDD:259829"
     Site            order(1200,1203,1223,1226,1229,1232,1254,1257)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..1269
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /coded_by="XM_047430347.1:27..3836"
                     /db_xref="GeneID:4008"
                     /db_xref="HGNC:HGNC:6646"
                     /db_xref="MIM:604362"
ORIGIN      
        1 mntrfllspi vwfpclsras sttkprfqdn invflkaceq iglkeaqlfh pgdlqdlsnr
       61 vtvkqeetdr rvknvlitly wlgrkaqsnp yyngphlnlk afenllgqal tkaledssfl
      121 krsgrdsgyg diwcpergef lapprhhkre dsfesldslg srsltscssd itlrggregf
      181 esdtdseftf kmqdynkddm syrrisavep ktalpfnrfl pnksrqpsyv paplrkkkpd
      241 khednrrswa spvyteadgt fsrlfqkiyg engsksmsdv saedvqnlrq lryeemqkik
      301 sqlkeqdqkw qddlakwkdr rksytsdlqk kkeereeiek qalekskrss ktfkemlqdr
      361 esqnqkstvp srrrmysfdd vleegkrppt mtvseasyqs erveekgaty pseipkedst
      421 tfakredrvt teiqlpsqsp veeqspasls slrsrstqme strvsaslpr syrktdtvrl
      481 tsvvtprpfg sqtrgisslp rsytmddawk yngdvedikr tpnnvvstpa pspdasqlas
      541 slssqkevaa teedvtrlps ptspfsslsq dqaatskatl sstsgldlms esgegeispq
      601 revsrsqdqf sdmrisinqt pgksldfgft ikwdipgifv asveagspae fsqlqvddei
      661 iainntkfsy ndskeweeam akaqetghlv mdvrrygkag spetkwidat sgiynsekss
      721 nlsvttdfse slqssniesk eingihdesn afeskasesi slknlkrrsq ffeqgssgfs
      781 ysswvylcgs sdsvvpdlpv ptisapsrwv wdqeeerkrq erwqkeqdrl lqekyqreqe
      841 klreewqrak qeaerensky ldeelmvlss nsmslttrep slatweatws egskssdreg
      901 trageeerrq pqeevvhedq gkkpqdqlvi ererkweqql qeeqeqkrlq aeaeeqkrpa
      961 eeqkrqaeie retsvriyqy rrpvdsydip kteeassgfl pgdrnksrst telddystnk
     1021 ngnnkyldqi gnmtssqrrs kkeqvpsgae lerqqilqem rkrtplhndn swirqrsasv
     1081 nkepvslpgi mrrgesldnl dsprsnswrq ppwlnqptgf yasssvqdfs rpppqlvsts
     1141 nraymrnpss svpppsagsv ktsttgvatt qsptprshsp sasqsgsqlr nrsvsgkric
     1201 sycnnilgkg aamiieslgl cyhlhcfkcv acecdlggss sgaevrirnh qlycndcylr
     1261 fksgrptam
//
LOCUS       XP_047286304            1268 aa            linear   PRI 05-AUG-2025
DEFINITION  LIM domain only protein 7 isoform X40 [Homo sapiens].
ACCESSION   XP_047286304
VERSION     XP_047286304.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430348.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1268
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1268
                     /product="LIM domain only protein 7 isoform X40"
                     /calculated_mol_wt=144457
     Region          <42..100
                     /region_name="CH_SF"
                     /note="calponin homology (CH) domain superfamily; cl00030"
                     /db_xref="CDD:469584"
     Site            order(42,45..46,48,62..66,84,86..87,89..90,93..94,97)
                     /site_type="other"
                     /note="actin binding site [polypeptide binding]"
                     /db_xref="CDD:409031"
     Region          213..372
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Site            order(637..638,641..645,654,657,689,693,696..697)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467153"
     Region          640..708
                     /region_name="PDZ"
                     /note="Domain present in PSD-95, Dlg, and ZO-1/2;
                     smart00228"
                     /db_xref="CDD:214570"
     Region          <815..>1096
                     /region_name="DUF5401"
                     /note="Family of unknown function (DUF5401); pfam17380"
                     /db_xref="CDD:375164"
     Region          1199..1257
                     /region_name="LIM"
                     /note="LIM is a small protein-protein interaction domain,
                     containing two zinc fingers; cd08368"
                     /db_xref="CDD:259829"
     Site            order(1199,1202,1222,1225,1228,1231,1253,1256)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..1268
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /coded_by="XM_047430348.1:14..3820"
                     /db_xref="GeneID:4008"
                     /db_xref="HGNC:HGNC:6646"
                     /db_xref="MIM:604362"
ORIGIN      
        1 mpghkiarlc mlwrterlyk pyvfffkyty awvlllplll tdninvflka ceqiglkeaq
       61 lfhpgdlqdl snrvtvkqee tdrrvknvli tlywlgrkaq snpyyngphl nlkafenllg
      121 qaltkaleds sflkrsgrds gygdiwcper geflapprhh kredsfesld slgsrsltsc
      181 ssditlrggr egfesdtdse ftfkmqdynk ddmsyrrisa vepktalpfn rflpnksrqp
      241 syvpaplrkk kpdkhednrr swaspvytea dgtfsrlfqk iygengsksm sdvsaedvqn
      301 lrqlryeemq kiksqlkeqd qkwqddlakw kdrrksytsd lqkkkeeree iekqaleksk
      361 rssktfkeml qdresqnqks tvpsrrrmys fddvleegkr pptmtvseas yqserveekg
      421 atypseipke dsttfakred rvtteiqlps qspveeqspa slsslrsrst qmestrvsas
      481 lprsyrktdt vrltsvvtpr pfgsqtrgis slprsytmdd awkyngdved ikrtpnnvvs
      541 tpapspdasq lasslssqke vaateedvtr lpsptspfss lsqdqaatsk atlsstsgld
      601 lmsesgegei spqrevsrsq dqfsdmrisi nqtpgksldf gftikwdipg ifvasveags
      661 paefsqlqvd deiiainntk fsyndskewe eamakaqetg hlvmdvrryg kagspetkwi
      721 datsgiynse kssnlsvttd fseslqssni eskeingihd esnafeskas esislknlkr
      781 rsqffeqgss dsvvpdlpvp tisapsrwvw dqeeerkrqe rwqkeqdrll qekyqreqek
      841 lreewqrakq eaerenskyl deelmvlssn smslttreps latweatwse gskssdregt
      901 rageeerrqp qeevvhedqg kkpqdqlvie rerkweqqlq eeqeqkrlqa eaeeqkrpae
      961 eqkrqaeier etsvriyqyr rpvdsydipk teeassgflp gdrnksrstt elddystnkn
     1021 gnnkyldqig nmtssqrrsk keqvpsgael erqqilqemr krtplhndns wirqrsasvn
     1081 kepvslpgim rrgesldnld sprsnswrqp pwlnqptgfy asssvqdfsr pppqlvstsn
     1141 raymrnpsss vpppsagsvk tsttgvattq sptprshsps asqsgsqlrn rsvsgkrics
     1201 ycnnilgkga amiieslglc yhlhcfkcva cecdlggsss gaevrirnhq lycndcylrf
     1261 ksgrptam
//
LOCUS       XP_047286305            1258 aa            linear   PRI 05-AUG-2025
DEFINITION  LIM domain only protein 7 isoform X41 [Homo sapiens].
ACCESSION   XP_047286305
VERSION     XP_047286305.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430349.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1258
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1258
                     /product="LIM domain only protein 7 isoform X41"
                     /calculated_mol_wt=143307
     Region          <42..100
                     /region_name="CH_SF"
                     /note="calponin homology (CH) domain superfamily; cl00030"
                     /db_xref="CDD:469584"
     Site            order(42,45..46,48,62..66,84,86..87,89..90,93..94,97)
                     /site_type="other"
                     /note="actin binding site [polypeptide binding]"
                     /db_xref="CDD:409031"
     Region          213..362
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Site            order(627..628,631..635,644,647,679,683,686..687)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467153"
     Region          630..698
                     /region_name="PDZ"
                     /note="Domain present in PSD-95, Dlg, and ZO-1/2;
                     smart00228"
                     /db_xref="CDD:214570"
     Region          <802..858
                     /region_name="GBP_C"
                     /note="Guanylate-binding protein, C-terminal domain;
                     cd16269"
                     /db_xref="CDD:293879"
     Region          <805..>960
                     /region_name="DUF5401"
                     /note="Family of unknown function (DUF5401); pfam17380"
                     /db_xref="CDD:375164"
     Region          845..856
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:293879"
     Region          1189..1247
                     /region_name="LIM"
                     /note="LIM is a small protein-protein interaction domain,
                     containing two zinc fingers; cd08368"
                     /db_xref="CDD:259829"
     Site            order(1189,1192,1212,1215,1218,1221,1243,1246)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..1258
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /coded_by="XM_047430349.1:14..3790"
                     /db_xref="GeneID:4008"
                     /db_xref="HGNC:HGNC:6646"
                     /db_xref="MIM:604362"
ORIGIN      
        1 mpghkiarlc mlwrterlyk pyvfffkyty awvlllplll tdninvflka ceqiglkeaq
       61 lfhpgdlqdl snrvtvkqee tdrrvknvli tlywlgrkaq snpyyngphl nlkafenllg
      121 qaltkaleds sflkrsgrds gygdiwcper geflapprhh kredsfesld slgsrsltsc
      181 ssditlrggr egfesdtdse ftfkmqdynk ddmsyrrisa vepktalpfn rflpnksrqp
      241 syvpaplrkk kpdkhednrr swaspvytea dgtfsrsksm sdvsaedvqn lrqlryeemq
      301 kiksqlkeqd qkwqddlakw kdrrksytsd lqkkkeeree iekqaleksk rssktfkeml
      361 qdresqnqks tvpsrrrmys fddvleegkr pptmtvseas yqserveekg atypseipke
      421 dsttfakred rvtteiqlps qspveeqspa slsslrsrst qmestrvsas lprsyrktdt
      481 vrltsvvtpr pfgsqtrgis slprsytmdd awkyngdved ikrtpnnvvs tpapspdasq
      541 lasslssqke vaateedvtr lpsptspfss lsqdqaatsk atlsstsgld lmsesgegei
      601 spqrevsrsq dqfsdmrisi nqtpgksldf gftikwdipg ifvasveags paefsqlqvd
      661 deiiainntk fsyndskewe eamakaqetg hlvmdvrryg kagspetkwi datsgiynse
      721 kssnlsvttd fseslqssni eskeingihd esnafeskas esislknlkr rsqffeqgss
      781 dsvvpdlpvp tisapsrwvw dqeeerkrqe rwqkeqdrll qekyqreqek lreewqrakq
      841 eaerenskyl deelmvlssn smslttreps latweatwse gskssdregt rageeerrqp
      901 qeevvhedqg kkpqdqlvie rerkweqqlq eeqeqkrlqa eaeeqkrpae eqkrqaeier
      961 etsvriyqyr rpvdsydipk teeassgflp gdrnksrstt elddystnkn gnnkyldqig
     1021 nmtssqrrsk keqvpsgael erqqilqemr krtplhndns wirqrsasvn kepvslpgim
     1081 rrgesldnld sprsnswrqp pwlnqptgfy asssvqdfsr pppqlvstsn raymrnpsss
     1141 vpppsagsvk tsttgvattq sptprshsps asqsgsqlrn rsvsgkrics ycnnilgkga
     1201 amiieslglc yhlhcfkcva cecdlggsss gaevrirnhq lycndcylrf ksgrptam
//
LOCUS       XP_047286306            1255 aa            linear   PRI 05-AUG-2025
DEFINITION  LIM domain only protein 7 isoform X42 [Homo sapiens].
ACCESSION   XP_047286306
VERSION     XP_047286306.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430350.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1255
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1255
                     /product="LIM domain only protein 7 isoform X42"
                     /calculated_mol_wt=142649
     Region          <29..87
                     /region_name="CH_SF"
                     /note="calponin homology (CH) domain superfamily; cl00030"
                     /db_xref="CDD:469584"
     Site            order(29,32..33,35,49..53,71,73..74,76..77,80..81,84)
                     /site_type="other"
                     /note="actin binding site [polypeptide binding]"
                     /db_xref="CDD:409031"
     Region          200..359
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Site            order(624..625,628..632,641,644,676,680,683..684)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467153"
     Region          627..695
                     /region_name="PDZ"
                     /note="Domain present in PSD-95, Dlg, and ZO-1/2;
                     smart00228"
                     /db_xref="CDD:214570"
     Region          <799..855
                     /region_name="GBP_C"
                     /note="Guanylate-binding protein, C-terminal domain;
                     cd16269"
                     /db_xref="CDD:293879"
     Region          <802..>957
                     /region_name="DUF5401"
                     /note="Family of unknown function (DUF5401); pfam17380"
                     /db_xref="CDD:375164"
     Region          842..853
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:293879"
     Region          1186..1244
                     /region_name="LIM"
                     /note="LIM is a small protein-protein interaction domain,
                     containing two zinc fingers; cd08368"
                     /db_xref="CDD:259829"
     Site            order(1186,1189,1209,1212,1215,1218,1240,1243)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..1255
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /coded_by="XM_047430350.1:27..3794"
                     /db_xref="GeneID:4008"
                     /db_xref="HGNC:HGNC:6646"
                     /db_xref="MIM:604362"
ORIGIN      
        1 mntrfllspi vwfpclsras sttkprfqdn invflkaceq iglkeaqlfh pgdlqdlsnr
       61 vtvkqeetdr rvknvlitly wlgrkaqsnp yyngphlnlk afenllgqal tkaledssfl
      121 krsgrdsgyg diwcpergef lapprhhkre dsfesldslg srsltscssd itlrggregf
      181 esdtdseftf kmqdynkddm syrrisavep ktalpfnrfl pnksrqpsyv paplrkkkpd
      241 khednrrswa spvyteadgt fsrlfqkiyg engsksmsdv saedvqnlrq lryeemqkik
      301 sqlkeqdqkw qddlakwkdr rksytsdlqk kkeereeiek qalekskrss ktfkemlqdr
      361 esqnqkstvp srrrmysfdd vleegkrppt mtvseasyqs erveekgaty pseipkedst
      421 tfakredrvt teiqlpsqsp veeqspasls slrsrstqme strvsaslpr syrktdtvrl
      481 tsvvtprpfg sqtrgisslp rsytmddawk yngdvedikr tpnnvvstpa pspdasqlas
      541 slssqkevaa teedvtrlps ptspfsslsq dqaatskatl sstsgldlms esgegeispq
      601 revsrsqdqf sdmrisinqt pgksldfgft ikwdipgifv asveagspae fsqlqvddei
      661 iainntkfsy ndskeweeam akaqetghlv mdvrrygkag spetkwidat sgiynsekss
      721 nlsvttdfse slqssniesk eingihdesn afeskasesi slknlkrrsq ffeqgssdsv
      781 vpdlpvptis apsrwvwdqe eerkrqerwq keqdrllqek yqreqeklre ewqrakqeae
      841 renskyldee lmvlssnsms lttrepslat weatwsegsk ssdregtrag eeerrqpqee
      901 vvhedqgkkp qdqlvierer kweqqlqeeq eqkrlqaeae eqkrpaeeqk rqaeierets
      961 vriyqyrrpv dsydipktee assgflpgdr nksrstteld dystnkngnn kyldqignmt
     1021 ssqrrskkeq vpsgaelerq qilqemrkrt plhndnswir qrsasvnkep vslpgimrrg
     1081 esldnldspr snswrqppwl nqptgfyass svqdfsrppp qlvstsnray mrnpsssvpp
     1141 psagsvktst tgvattqspt prshspsasq sgsqlrnrsv sgkricsycn nilgkgaami
     1201 ieslglcyhl hcfkcvacec dlggsssgae vrirnhqlyc ndcylrfksg rptam
//
LOCUS       XP_047286307            1249 aa            linear   PRI 05-AUG-2025
DEFINITION  LIM domain only protein 7 isoform X43 [Homo sapiens].
ACCESSION   XP_047286307
VERSION     XP_047286307.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430351.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1249
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1249
                     /product="LIM domain only protein 7 isoform X43"
                     /calculated_mol_wt=142206
     Region          <42..100
                     /region_name="CH_SF"
                     /note="calponin homology (CH) domain superfamily; cl00030"
                     /db_xref="CDD:469584"
     Site            order(42,45..46,48,62..66,84,86..87,89..90,93..94,97)
                     /site_type="other"
                     /note="actin binding site [polypeptide binding]"
                     /db_xref="CDD:409031"
     Region          213..372
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Site            order(637..638,641..645,654,657,689,693,696..697)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467153"
     Region          640..708
                     /region_name="PDZ"
                     /note="Domain present in PSD-95, Dlg, and ZO-1/2;
                     smart00228"
                     /db_xref="CDD:214570"
     Region          <796..>1077
                     /region_name="DUF5401"
                     /note="Family of unknown function (DUF5401); pfam17380"
                     /db_xref="CDD:375164"
     Region          1180..1238
                     /region_name="LIM"
                     /note="LIM is a small protein-protein interaction domain,
                     containing two zinc fingers; cd08368"
                     /db_xref="CDD:259829"
     Site            order(1180,1183,1203,1206,1209,1212,1234,1237)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..1249
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /coded_by="XM_047430351.1:14..3763"
                     /db_xref="GeneID:4008"
                     /db_xref="HGNC:HGNC:6646"
                     /db_xref="MIM:604362"
ORIGIN      
        1 mpghkiarlc mlwrterlyk pyvfffkyty awvlllplll tdninvflka ceqiglkeaq
       61 lfhpgdlqdl snrvtvkqee tdrrvknvli tlywlgrkaq snpyyngphl nlkafenllg
      121 qaltkaleds sflkrsgrds gygdiwcper geflapprhh kredsfesld slgsrsltsc
      181 ssditlrggr egfesdtdse ftfkmqdynk ddmsyrrisa vepktalpfn rflpnksrqp
      241 syvpaplrkk kpdkhednrr swaspvytea dgtfsrlfqk iygengsksm sdvsaedvqn
      301 lrqlryeemq kiksqlkeqd qkwqddlakw kdrrksytsd lqkkkeeree iekqaleksk
      361 rssktfkeml qdresqnqks tvpsrrrmys fddvleegkr pptmtvseas yqserveekg
      421 atypseipke dsttfakred rvtteiqlps qspveeqspa slsslrsrst qmestrvsas
      481 lprsyrktdt vrltsvvtpr pfgsqtrgis slprsytmdd awkyngdved ikrtpnnvvs
      541 tpapspdasq lasslssqke vaateedvtr lpsptspfss lsqdqaatsk atlsstsgld
      601 lmsesgegei spqrevsrsq dqfsdmrisi nqtpgksldf gftikwdipg ifvasveags
      661 paefsqlqvd deiiainntk fsyndskewe eamakaqetg hlvmdvrryg kagspetkwi
      721 datsgiynse kssnlsvttd fseslqssni eskeingihd esnafeskgs sdsvvpdlpv
      781 ptisapsrwv wdqeeerkrq erwqkeqdrl lqekyqreqe klreewqrak qeaerensky
      841 ldeelmvlss nsmslttrep slatweatws egskssdreg trageeerrq pqeevvhedq
      901 gkkpqdqlvi ererkweqql qeeqeqkrlq aeaeeqkrpa eeqkrqaeie retsvriyqy
      961 rrpvdsydip kteeassgfl pgdrnksrst telddystnk ngnnkyldqi gnmtssqrrs
     1021 kkeqvpsgae lerqqilqem rkrtplhndn swirqrsasv nkepvslpgi mrrgesldnl
     1081 dsprsnswrq ppwlnqptgf yasssvqdfs rpppqlvsts nraymrnpss svpppsagsv
     1141 ktsttgvatt qsptprshsp sasqsgsqlr nrsvsgkric sycnnilgkg aamiieslgl
     1201 cyhlhcfkcv acecdlggss sgaevrirnh qlycndcylr fksgrptam
//
LOCUS       XP_047286308            1105 aa            linear   PRI 05-AUG-2025
DEFINITION  LIM domain only protein 7 isoform X44 [Homo sapiens].
ACCESSION   XP_047286308
VERSION     XP_047286308.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430352.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1105
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1105
                     /product="LIM domain only protein 7 isoform X44"
                     /calculated_mol_wt=125546
     Region          9..168
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Site            order(433..434,437..441,450,453,485,489,492..493)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467153"
     Region          436..504
                     /region_name="PDZ"
                     /note="Domain present in PSD-95, Dlg, and ZO-1/2;
                     smart00228"
                     /db_xref="CDD:214570"
     Region          <649..705
                     /region_name="GBP_C"
                     /note="Guanylate-binding protein, C-terminal domain;
                     cd16269"
                     /db_xref="CDD:293879"
     Region          <652..>807
                     /region_name="DUF5401"
                     /note="Family of unknown function (DUF5401); pfam17380"
                     /db_xref="CDD:375164"
     Region          692..703
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:293879"
     Region          1036..1094
                     /region_name="LIM"
                     /note="LIM is a small protein-protein interaction domain,
                     containing two zinc fingers; cd08368"
                     /db_xref="CDD:259829"
     Site            order(1036,1039,1059,1062,1065,1068,1090,1093)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..1105
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /coded_by="XM_047430352.1:655..3972"
                     /db_xref="GeneID:4008"
                     /db_xref="HGNC:HGNC:6646"
                     /db_xref="MIM:604362"
ORIGIN      
        1 mqdynkddms yrrisavepk talpfnrflp nksrqpsyvp aplrkkkpdk hednrrswas
       61 pvyteadgtf srlfqkiyge ngsksmsdvs aedvqnlrql ryeemqkiks qlkeqdqkwq
      121 ddlakwkdrr ksytsdlqkk keereeiekq alekskrssk tfkemlqdre sqnqkstvps
      181 rrrmysfddv leegkrpptm tvseasyqse rveekgatyp seipkedstt fakredrvtt
      241 eiqlpsqspv eeqspaslss lrsrstqmes trvsaslprs yrktdtvrlt svvtprpfgs
      301 qtrgisslpr sytmddawky ngdvedikrt pnnvvstpap spdasqlass lssqkevaat
      361 eedvtrlpsp tspfsslsqd qaatskatls stsgldlmse sgegeispqr evsrsqdqfs
      421 dmrisinqtp gksldfgfti kwdipgifva sveagspaef sqlqvddeii ainntkfsyn
      481 dskeweeama kaqetghlvm dvrrygkadw gkdqpslpfi rhktlnltsm atkiigspet
      541 kwidatsgiy nsekssnlsv ttdfseslqs snieskeing ihdesnafes kasesislkn
      601 lkrrsqffeq gssgfsyssw vylcgssdsv vpdlpvptis apsrwvwdqe eerkrqerwq
      661 keqdrllqek yqreqeklre ewqrakqeae renskyldee lmvlssnsms lttrepslat
      721 weatwsegsk ssdregtrag eeerrqpqee vvhedqgkkp qdqlvierer kweqqlqeeq
      781 eqkrlqaeae eqkrpaeeqk rqaeierets vriyqyrrpv dsydipktee assgflpgdr
      841 nksrstteld dystnkngnn kyldqignmt ssqrrskkeq vpsgaelerq qilqemrkrt
      901 plhndnswir qrsasvnkep vslpgimrrg esldnldspr snswrqppwl nqptgfyass
      961 svqdfsrppp qlvstsnray mrnpsssvpp psagsvktst tgvattqspt prshspsasq
     1021 sgsqlrnrsv sgkricsycn nilgkgaami ieslglcyhl hcfkcvacec dlggsssgae
     1081 vrirnhqlyc ndcylrfksg rptam
//
LOCUS       XP_047286309            1062 aa            linear   PRI 05-AUG-2025
DEFINITION  LIM domain only protein 7 isoform X45 [Homo sapiens].
ACCESSION   XP_047286309
VERSION     XP_047286309.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430353.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 1% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1062
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1062
                     /product="LIM domain only protein 7 isoform X45"
                     /calculated_mol_wt=120621
     Region          9..158
                     /region_name="DUF4757"
                     /note="Domain of unknown function (DUF4757); pfam15949"
                     /db_xref="CDD:464950"
     Site            order(423..424,427..431,440,443,475,479,482..483)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467153"
     Region          426..494
                     /region_name="PDZ"
                     /note="Domain present in PSD-95, Dlg, and ZO-1/2;
                     smart00228"
                     /db_xref="CDD:214570"
     Region          <606..662
                     /region_name="GBP_C"
                     /note="Guanylate-binding protein, C-terminal domain;
                     cd16269"
                     /db_xref="CDD:293879"
     Region          <609..>764
                     /region_name="DUF5401"
                     /note="Family of unknown function (DUF5401); pfam17380"
                     /db_xref="CDD:375164"
     Region          649..660
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:293879"
     Region          993..1051
                     /region_name="LIM"
                     /note="LIM is a small protein-protein interaction domain,
                     containing two zinc fingers; cd08368"
                     /db_xref="CDD:259829"
     Site            order(993,996,1016,1019,1022,1025,1047,1050)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..1062
                     /gene="LMO7"
                     /gene_synonym="FBX20; FBXO20; LMO7b; LOMP"
                     /coded_by="XM_047430353.1:761..3949"
                     /db_xref="GeneID:4008"
                     /db_xref="HGNC:HGNC:6646"
                     /db_xref="MIM:604362"
ORIGIN      
        1 mqdynkddms yrrisavepk talpfnrflp nksrqpsyvp aplrkkkpdk hednrrswas
       61 pvyteadgtf srsksmsdvs aedvqnlrql ryeemqkiks qlkeqdqkwq ddlakwkdrr
      121 ksytsdlqkk keereeiekq alekskrssk tfkemlqdre sqnqkstvps rrrmysfddv
      181 leegkrpptm tvseasyqse rveekgatyp seipkedstt fakredrvtt eiqlpsqspv
      241 eeqspaslss lrsrstqmes trvsaslprs yrktdtvrlt svvtprpfgs qtrgisslpr
      301 sytmddawky ngdvedikrt pnnvvstpap spdasqlass lssqkevaat eedvtrlpsp
      361 tspfsslsqd qaatskatls stsgldlmse sgegeispqr evsrsqdqfs dmrisinqtp
      421 gksldfgfti kwdipgifva sveagspaef sqlqvddeii ainntkfsyn dskeweeama
      481 kaqetghlvm dvrrygkadw gkdqpslpfi rhktlnltsm atkiigspet kwidatsgiy
      541 nsekssnlsv ttdfseslqs snieskeing ihdesnafes kgssdsvvpd lpvptisaps
      601 rwvwdqeeer krqerwqkeq drllqekyqr eqeklreewq rakqeaeren skyldeelmv
      661 lssnsmsltt repslatwea twsegskssd regtrageee rrqpqeevvh edqgkkpqdq
      721 lviererkwe qqlqeeqeqk rlqaeaeeqk rpaeeqkrqa eieretsvri yqyrrpvdsy
      781 dipkteeass gflpgdrnks rsttelddys tnkngnnkyl dqignmtssq rrskkeqvps
      841 gaelerqqil qemrkrtplh ndnswirqrs asvnkepvsl pgimrrgesl dnldsprsns
      901 wrqppwlnqp tgfyasssvq dfsrpppqlv stsnraymrn psssvpppsa gsvktsttgv
      961 attqsptprs hspsasqsgs qlrnrsvsgk ricsycnnil gkgaamiies lglcyhlhcf
     1021 kcvacecdlg gsssgaevri rnhqlycndc ylrfksgrpt am
//
LOCUS       XP_047286310             479 aa            linear   PRI 05-AUG-2025
DEFINITION  mothers against decapentaplegic homolog 9 isoform X1 [Homo
            sapiens].
ACCESSION   XP_047286310
VERSION     XP_047286310.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430354.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..479
                     /product="mothers against decapentaplegic homolog 9
                     isoform X1"
                     /calculated_mol_wt=53642
     Region          13..136
                     /region_name="MH1_SMAD_1_5_9"
                     /note="N-terminal Mad Homology 1 (MH1) domain in SMAD1,
                     SMAD5 and SMAD9 (also known as SMAD8); cd10490"
                     /db_xref="CDD:199814"
     Site            order(36,40,74..75,78..82,85,104)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:199814"
     Site            order(68,113,125,130)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:199814"
     Region          <140..>258
                     /region_name="Atrophin-1"
                     /note="Atrophin-1 family; pfam03154"
                     /db_xref="CDD:460830"
     Region          267..>420
                     /region_name="MH2"
                     /note="C-terminal Mad Homology 2 (MH2) domain; cl00056"
                     /db_xref="CDD:469593"
     Site            order(279,287..288,290,301..305,310,314..317,319,326,
                     330..331,333,406,409)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:199819"
     CDS             1..479
                     /gene="SMAD9"
                     /gene_synonym="MADH6; MADH9; PPH2; SMAD8; SMAD8/9; SMAD8A;
                     SMAD8B"
                     /coded_by="XM_047430354.1:310..1749"
                     /db_xref="GeneID:4093"
                     /db_xref="HGNC:HGNC:6774"
                     /db_xref="MIM:603295"
ORIGIN      
        1 mhsttpissl fsftspavkr llgwkqgdee ekwaekavds lvkklkkkkg amdelerals
       61 cpgqpskcvt iprsldgrlq vshrkglphv iycrvwrwpd lqshhelkpl eccefpfgsk
      121 qkevcinpyh yrrvetpvlp pvlvprhsey npqlsllakf rsaslhsepl mphnatypds
      181 fqqppcsalp pspshafsqs pctasyphsp gspsepespy qhsvdtpplp yhateasetq
      241 sgqpvdatad rhvvlsipng dfrpvcyeep qhwcsvayye lnnrvgetfq assrsvlidg
      301 ftdpsnnrnr fclgllsnvn rnstientrr higkgvhlyy vggevyaecv sdssifvqsr
      361 ncnyqhgfhp atvckipsgc slkvfnnqlf aqllaqsvhh gfevvyeltk mctirmsfvk
      421 vamkageprk flsgkerqlg lymevkafsf itcyfvcckv lanessisky glikvsgyv
//
LOCUS       XP_047286311             479 aa            linear   PRI 05-AUG-2025
DEFINITION  mothers against decapentaplegic homolog 9 isoform X1 [Homo
            sapiens].
ACCESSION   XP_047286311
VERSION     XP_047286311.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430355.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..479
                     /product="mothers against decapentaplegic homolog 9
                     isoform X1"
                     /calculated_mol_wt=53642
     Region          13..136
                     /region_name="MH1_SMAD_1_5_9"
                     /note="N-terminal Mad Homology 1 (MH1) domain in SMAD1,
                     SMAD5 and SMAD9 (also known as SMAD8); cd10490"
                     /db_xref="CDD:199814"
     Site            order(36,40,74..75,78..82,85,104)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:199814"
     Site            order(68,113,125,130)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:199814"
     Region          <140..>258
                     /region_name="Atrophin-1"
                     /note="Atrophin-1 family; pfam03154"
                     /db_xref="CDD:460830"
     Region          267..>420
                     /region_name="MH2"
                     /note="C-terminal Mad Homology 2 (MH2) domain; cl00056"
                     /db_xref="CDD:469593"
     Site            order(279,287..288,290,301..305,310,314..317,319,326,
                     330..331,333,406,409)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:199819"
     CDS             1..479
                     /gene="SMAD9"
                     /gene_synonym="MADH6; MADH9; PPH2; SMAD8; SMAD8/9; SMAD8A;
                     SMAD8B"
                     /coded_by="XM_047430355.1:2566..4005"
                     /db_xref="GeneID:4093"
                     /db_xref="HGNC:HGNC:6774"
                     /db_xref="MIM:603295"
ORIGIN      
        1 mhsttpissl fsftspavkr llgwkqgdee ekwaekavds lvkklkkkkg amdelerals
       61 cpgqpskcvt iprsldgrlq vshrkglphv iycrvwrwpd lqshhelkpl eccefpfgsk
      121 qkevcinpyh yrrvetpvlp pvlvprhsey npqlsllakf rsaslhsepl mphnatypds
      181 fqqppcsalp pspshafsqs pctasyphsp gspsepespy qhsvdtpplp yhateasetq
      241 sgqpvdatad rhvvlsipng dfrpvcyeep qhwcsvayye lnnrvgetfq assrsvlidg
      301 ftdpsnnrnr fclgllsnvn rnstientrr higkgvhlyy vggevyaecv sdssifvqsr
      361 ncnyqhgfhp atvckipsgc slkvfnnqlf aqllaqsvhh gfevvyeltk mctirmsfvk
      421 vamkageprk flsgkerqlg lymevkafsf itcyfvcckv lanessisky glikvsgyv
//
LOCUS       XP_006719890             479 aa            linear   PRI 05-AUG-2025
DEFINITION  mothers against decapentaplegic homolog 9 isoform X1 [Homo
            sapiens].
ACCESSION   XP_006719890
VERSION     XP_006719890.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006719827.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..479
                     /product="mothers against decapentaplegic homolog 9
                     isoform X1"
                     /calculated_mol_wt=53642
     Region          13..136
                     /region_name="MH1_SMAD_1_5_9"
                     /note="N-terminal Mad Homology 1 (MH1) domain in SMAD1,
                     SMAD5 and SMAD9 (also known as SMAD8); cd10490"
                     /db_xref="CDD:199814"
     Site            order(36,40,74..75,78..82,85,104)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:199814"
     Site            order(68,113,125,130)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:199814"
     Region          <140..>258
                     /region_name="Atrophin-1"
                     /note="Atrophin-1 family; pfam03154"
                     /db_xref="CDD:460830"
     Region          267..>420
                     /region_name="MH2"
                     /note="C-terminal Mad Homology 2 (MH2) domain; cl00056"
                     /db_xref="CDD:469593"
     Site            order(279,287..288,290,301..305,310,314..317,319,326,
                     330..331,333,406,409)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:199819"
     CDS             1..479
                     /gene="SMAD9"
                     /gene_synonym="MADH6; MADH9; PPH2; SMAD8; SMAD8/9; SMAD8A;
                     SMAD8B"
                     /coded_by="XM_006719827.4:407..1846"
                     /db_xref="GeneID:4093"
                     /db_xref="HGNC:HGNC:6774"
                     /db_xref="MIM:603295"
ORIGIN      
        1 mhsttpissl fsftspavkr llgwkqgdee ekwaekavds lvkklkkkkg amdelerals
       61 cpgqpskcvt iprsldgrlq vshrkglphv iycrvwrwpd lqshhelkpl eccefpfgsk
      121 qkevcinpyh yrrvetpvlp pvlvprhsey npqlsllakf rsaslhsepl mphnatypds
      181 fqqppcsalp pspshafsqs pctasyphsp gspsepespy qhsvdtpplp yhateasetq
      241 sgqpvdatad rhvvlsipng dfrpvcyeep qhwcsvayye lnnrvgetfq assrsvlidg
      301 ftdpsnnrnr fclgllsnvn rnstientrr higkgvhlyy vggevyaecv sdssifvqsr
      361 ncnyqhgfhp atvckipsgc slkvfnnqlf aqllaqsvhh gfevvyeltk mctirmsfvk
      421 vamkageprk flsgkerqlg lymevkafsf itcyfvcckv lanessisky glikvsgyv
//
LOCUS       XP_047286312             479 aa            linear   PRI 05-AUG-2025
DEFINITION  mothers against decapentaplegic homolog 9 isoform X1 [Homo
            sapiens].
ACCESSION   XP_047286312
VERSION     XP_047286312.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430356.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..479
                     /product="mothers against decapentaplegic homolog 9
                     isoform X1"
                     /calculated_mol_wt=53642
     Region          13..136
                     /region_name="MH1_SMAD_1_5_9"
                     /note="N-terminal Mad Homology 1 (MH1) domain in SMAD1,
                     SMAD5 and SMAD9 (also known as SMAD8); cd10490"
                     /db_xref="CDD:199814"
     Site            order(36,40,74..75,78..82,85,104)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:199814"
     Site            order(68,113,125,130)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:199814"
     Region          <140..>258
                     /region_name="Atrophin-1"
                     /note="Atrophin-1 family; pfam03154"
                     /db_xref="CDD:460830"
     Region          267..>420
                     /region_name="MH2"
                     /note="C-terminal Mad Homology 2 (MH2) domain; cl00056"
                     /db_xref="CDD:469593"
     Site            order(279,287..288,290,301..305,310,314..317,319,326,
                     330..331,333,406,409)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:199819"
     CDS             1..479
                     /gene="SMAD9"
                     /gene_synonym="MADH6; MADH9; PPH2; SMAD8; SMAD8/9; SMAD8A;
                     SMAD8B"
                     /coded_by="XM_047430356.1:213..1652"
                     /db_xref="GeneID:4093"
                     /db_xref="HGNC:HGNC:6774"
                     /db_xref="MIM:603295"
ORIGIN      
        1 mhsttpissl fsftspavkr llgwkqgdee ekwaekavds lvkklkkkkg amdelerals
       61 cpgqpskcvt iprsldgrlq vshrkglphv iycrvwrwpd lqshhelkpl eccefpfgsk
      121 qkevcinpyh yrrvetpvlp pvlvprhsey npqlsllakf rsaslhsepl mphnatypds
      181 fqqppcsalp pspshafsqs pctasyphsp gspsepespy qhsvdtpplp yhateasetq
      241 sgqpvdatad rhvvlsipng dfrpvcyeep qhwcsvayye lnnrvgetfq assrsvlidg
      301 ftdpsnnrnr fclgllsnvn rnstientrr higkgvhlyy vggevyaecv sdssifvqsr
      361 ncnyqhgfhp atvckipsgc slkvfnnqlf aqllaqsvhh gfevvyeltk mctirmsfvk
      421 vamkageprk flsgkerqlg lymevkafsf itcyfvcckv lanessisky glikvsgyv
//
LOCUS       XP_047286314             467 aa            linear   PRI 05-AUG-2025
DEFINITION  mothers against decapentaplegic homolog 9 isoform X2 [Homo
            sapiens].
ACCESSION   XP_047286314
VERSION     XP_047286314.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430358.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..467
                     /product="mothers against decapentaplegic homolog 9
                     isoform X2"
                     /calculated_mol_wt=52363
     Region          13..136
                     /region_name="MH1_SMAD_1_5_9"
                     /note="N-terminal Mad Homology 1 (MH1) domain in SMAD1,
                     SMAD5 and SMAD9 (also known as SMAD8); cd10490"
                     /db_xref="CDD:199814"
     Site            order(36,40,74..75,78..82,85,104)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:199814"
     Site            order(68,113,125,130)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:199814"
     Region          <140..>258
                     /region_name="Atrophin-1"
                     /note="Atrophin-1 family; pfam03154"
                     /db_xref="CDD:460830"
     Region          267..467
                     /region_name="MH2"
                     /note="C-terminal Mad Homology 2 (MH2) domain; cl00056"
                     /db_xref="CDD:469593"
     Site            order(279,287..288,290,301..305,310,314..317,319,326,
                     330..331,333,406,409,432,439,441,443)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:199822"
     CDS             1..467
                     /gene="SMAD9"
                     /gene_synonym="MADH6; MADH9; PPH2; SMAD8; SMAD8/9; SMAD8A;
                     SMAD8B"
                     /coded_by="XM_047430358.1:3567..4970"
                     /db_xref="GeneID:4093"
                     /db_xref="HGNC:HGNC:6774"
                     /db_xref="MIM:603295"
ORIGIN      
        1 mhsttpissl fsftspavkr llgwkqgdee ekwaekavds lvkklkkkkg amdelerals
       61 cpgqpskcvt iprsldgrlq vshrkglphv iycrvwrwpd lqshhelkpl eccefpfgsk
      121 qkevcinpyh yrrvetpvlp pvlvprhsey npqlsllakf rsaslhsepl mphnatypds
      181 fqqppcsalp pspshafsqs pctasyphsp gspsepespy qhsvdtpplp yhateasetq
      241 sgqpvdatad rhvvlsipng dfrpvcyeep qhwcsvayye lnnrvgetfq assrsvlidg
      301 ftdpsnnrnr fclgllsnvn rnstientrr higkgvhlyy vggevyaecv sdssifvqsr
      361 ncnyqhgfhp atvckipsgc slkvfnnqlf aqllaqsvhh gfevvyeltk mctirmsfvk
      421 gwgaeyhrqd vtstpcwiei hlhgplqwld kvltqmgsph npissvs
//
LOCUS       XP_047286315             467 aa            linear   PRI 05-AUG-2025
DEFINITION  mothers against decapentaplegic homolog 9 isoform X2 [Homo
            sapiens].
ACCESSION   XP_047286315
VERSION     XP_047286315.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430359.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..467
                     /product="mothers against decapentaplegic homolog 9
                     isoform X2"
                     /calculated_mol_wt=52363
     Region          13..136
                     /region_name="MH1_SMAD_1_5_9"
                     /note="N-terminal Mad Homology 1 (MH1) domain in SMAD1,
                     SMAD5 and SMAD9 (also known as SMAD8); cd10490"
                     /db_xref="CDD:199814"
     Site            order(36,40,74..75,78..82,85,104)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:199814"
     Site            order(68,113,125,130)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:199814"
     Region          <140..>258
                     /region_name="Atrophin-1"
                     /note="Atrophin-1 family; pfam03154"
                     /db_xref="CDD:460830"
     Region          267..467
                     /region_name="MH2"
                     /note="C-terminal Mad Homology 2 (MH2) domain; cl00056"
                     /db_xref="CDD:469593"
     Site            order(279,287..288,290,301..305,310,314..317,319,326,
                     330..331,333,406,409,432,439,441,443)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:199822"
     CDS             1..467
                     /gene="SMAD9"
                     /gene_synonym="MADH6; MADH9; PPH2; SMAD8; SMAD8/9; SMAD8A;
                     SMAD8B"
                     /coded_by="XM_047430359.1:2562..3965"
                     /db_xref="GeneID:4093"
                     /db_xref="HGNC:HGNC:6774"
                     /db_xref="MIM:603295"
ORIGIN      
        1 mhsttpissl fsftspavkr llgwkqgdee ekwaekavds lvkklkkkkg amdelerals
       61 cpgqpskcvt iprsldgrlq vshrkglphv iycrvwrwpd lqshhelkpl eccefpfgsk
      121 qkevcinpyh yrrvetpvlp pvlvprhsey npqlsllakf rsaslhsepl mphnatypds
      181 fqqppcsalp pspshafsqs pctasyphsp gspsepespy qhsvdtpplp yhateasetq
      241 sgqpvdatad rhvvlsipng dfrpvcyeep qhwcsvayye lnnrvgetfq assrsvlidg
      301 ftdpsnnrnr fclgllsnvn rnstientrr higkgvhlyy vggevyaecv sdssifvqsr
      361 ncnyqhgfhp atvckipsgc slkvfnnqlf aqllaqsvhh gfevvyeltk mctirmsfvk
      421 gwgaeyhrqd vtstpcwiei hlhgplqwld kvltqmgsph npissvs
//
LOCUS       XP_047286316             467 aa            linear   PRI 05-AUG-2025
DEFINITION  mothers against decapentaplegic homolog 9 isoform X2 [Homo
            sapiens].
ACCESSION   XP_047286316
VERSION     XP_047286316.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430360.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..467
                     /product="mothers against decapentaplegic homolog 9
                     isoform X2"
                     /calculated_mol_wt=52363
     Region          13..136
                     /region_name="MH1_SMAD_1_5_9"
                     /note="N-terminal Mad Homology 1 (MH1) domain in SMAD1,
                     SMAD5 and SMAD9 (also known as SMAD8); cd10490"
                     /db_xref="CDD:199814"
     Site            order(36,40,74..75,78..82,85,104)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:199814"
     Site            order(68,113,125,130)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:199814"
     Region          <140..>258
                     /region_name="Atrophin-1"
                     /note="Atrophin-1 family; pfam03154"
                     /db_xref="CDD:460830"
     Region          267..467
                     /region_name="MH2"
                     /note="C-terminal Mad Homology 2 (MH2) domain; cl00056"
                     /db_xref="CDD:469593"
     Site            order(279,287..288,290,301..305,310,314..317,319,326,
                     330..331,333,406,409,432,439,441,443)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:199822"
     CDS             1..467
                     /gene="SMAD9"
                     /gene_synonym="MADH6; MADH9; PPH2; SMAD8; SMAD8/9; SMAD8A;
                     SMAD8B"
                     /coded_by="XM_047430360.1:676..2079"
                     /db_xref="GeneID:4093"
                     /db_xref="HGNC:HGNC:6774"
                     /db_xref="MIM:603295"
ORIGIN      
        1 mhsttpissl fsftspavkr llgwkqgdee ekwaekavds lvkklkkkkg amdelerals
       61 cpgqpskcvt iprsldgrlq vshrkglphv iycrvwrwpd lqshhelkpl eccefpfgsk
      121 qkevcinpyh yrrvetpvlp pvlvprhsey npqlsllakf rsaslhsepl mphnatypds
      181 fqqppcsalp pspshafsqs pctasyphsp gspsepespy qhsvdtpplp yhateasetq
      241 sgqpvdatad rhvvlsipng dfrpvcyeep qhwcsvayye lnnrvgetfq assrsvlidg
      301 ftdpsnnrnr fclgllsnvn rnstientrr higkgvhlyy vggevyaecv sdssifvqsr
      361 ncnyqhgfhp atvckipsgc slkvfnnqlf aqllaqsvhh gfevvyeltk mctirmsfvk
      421 gwgaeyhrqd vtstpcwiei hlhgplqwld kvltqmgsph npissvs
//
LOCUS       XP_047286317             442 aa            linear   PRI 05-AUG-2025
DEFINITION  mothers against decapentaplegic homolog 9 isoform X3 [Homo
            sapiens].
ACCESSION   XP_047286317
VERSION     XP_047286317.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430361.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..442
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..442
                     /product="mothers against decapentaplegic homolog 9
                     isoform X3"
                     /calculated_mol_wt=49789
     Region          13..136
                     /region_name="MH1_SMAD_1_5_9"
                     /note="N-terminal Mad Homology 1 (MH1) domain in SMAD1,
                     SMAD5 and SMAD9 (also known as SMAD8); cd10490"
                     /db_xref="CDD:199814"
     Site            order(36,40,74..75,78..82,85,104)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:199814"
     Site            order(68,113,125,130)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:199814"
     Region          230..>383
                     /region_name="MH2"
                     /note="C-terminal Mad Homology 2 (MH2) domain; cl00056"
                     /db_xref="CDD:469593"
     Site            order(242,250..251,253,264..268,273,277..280,282,289,
                     293..294,296,369,372)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:199819"
     CDS             1..442
                     /gene="SMAD9"
                     /gene_synonym="MADH6; MADH9; PPH2; SMAD8; SMAD8/9; SMAD8A;
                     SMAD8B"
                     /coded_by="XM_047430361.1:310..1638"
                     /db_xref="GeneID:4093"
                     /db_xref="HGNC:HGNC:6774"
                     /db_xref="MIM:603295"
ORIGIN      
        1 mhsttpissl fsftspavkr llgwkqgdee ekwaekavds lvkklkkkkg amdelerals
       61 cpgqpskcvt iprsldgrlq vshrkglphv iycrvwrwpd lqshhelkpl eccefpfgsk
      121 qkevcinpyh yrrvetpvlp pvlvprhsey npqlsllakf rsaslhsepl mphnatypds
      181 fqqppcsalp pspshafsqs pctasyphsp gspsepespy qhsdfrpvcy eepqhwcsva
      241 yyelnnrvge tfqassrsvl idgftdpsnn rnrfclglls nvnrnstien trrhigkgvh
      301 lyyvggevya ecvsdssifv qsrncnyqhg fhpatvckip sgcslkvfnn qlfaqllaqs
      361 vhhgfevvye ltkmctirms fvkvamkage prkflsgker qlglymevka fsfitcyfvc
      421 ckvlanessi skyglikvsg yv
//
LOCUS       XP_047286318             442 aa            linear   PRI 05-AUG-2025
DEFINITION  mothers against decapentaplegic homolog 9 isoform X3 [Homo
            sapiens].
ACCESSION   XP_047286318
VERSION     XP_047286318.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430362.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..442
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..442
                     /product="mothers against decapentaplegic homolog 9
                     isoform X3"
                     /calculated_mol_wt=49789
     Region          13..136
                     /region_name="MH1_SMAD_1_5_9"
                     /note="N-terminal Mad Homology 1 (MH1) domain in SMAD1,
                     SMAD5 and SMAD9 (also known as SMAD8); cd10490"
                     /db_xref="CDD:199814"
     Site            order(36,40,74..75,78..82,85,104)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:199814"
     Site            order(68,113,125,130)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:199814"
     Region          230..>383
                     /region_name="MH2"
                     /note="C-terminal Mad Homology 2 (MH2) domain; cl00056"
                     /db_xref="CDD:469593"
     Site            order(242,250..251,253,264..268,273,277..280,282,289,
                     293..294,296,369,372)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:199819"
     CDS             1..442
                     /gene="SMAD9"
                     /gene_synonym="MADH6; MADH9; PPH2; SMAD8; SMAD8/9; SMAD8A;
                     SMAD8B"
                     /coded_by="XM_047430362.1:213..1541"
                     /db_xref="GeneID:4093"
                     /db_xref="HGNC:HGNC:6774"
                     /db_xref="MIM:603295"
ORIGIN      
        1 mhsttpissl fsftspavkr llgwkqgdee ekwaekavds lvkklkkkkg amdelerals
       61 cpgqpskcvt iprsldgrlq vshrkglphv iycrvwrwpd lqshhelkpl eccefpfgsk
      121 qkevcinpyh yrrvetpvlp pvlvprhsey npqlsllakf rsaslhsepl mphnatypds
      181 fqqppcsalp pspshafsqs pctasyphsp gspsepespy qhsdfrpvcy eepqhwcsva
      241 yyelnnrvge tfqassrsvl idgftdpsnn rnrfclglls nvnrnstien trrhigkgvh
      301 lyyvggevya ecvsdssifv qsrncnyqhg fhpatvckip sgcslkvfnn qlfaqllaqs
      361 vhhgfevvye ltkmctirms fvkvamkage prkflsgker qlglymevka fsfitcyfvc
      421 ckvlanessi skyglikvsg yv
//
LOCUS       XP_047286319             430 aa            linear   PRI 05-AUG-2025
DEFINITION  mothers against decapentaplegic homolog 9 isoform X4 [Homo
            sapiens].
ACCESSION   XP_047286319
VERSION     XP_047286319.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430363.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..430
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..430
                     /product="mothers against decapentaplegic homolog 9
                     isoform X4"
                     /calculated_mol_wt=48509
     Region          13..136
                     /region_name="MH1_SMAD_1_5_9"
                     /note="N-terminal Mad Homology 1 (MH1) domain in SMAD1,
                     SMAD5 and SMAD9 (also known as SMAD8); cd10490"
                     /db_xref="CDD:199814"
     Site            order(36,40,74..75,78..82,85,104)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:199814"
     Site            order(68,113,125,130)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:199814"
     Region          230..430
                     /region_name="MH2"
                     /note="C-terminal Mad Homology 2 (MH2) domain; cl00056"
                     /db_xref="CDD:469593"
     Site            order(242,250..251,253,264..268,273,277..280,282,289,
                     293..294,296,369,372,395,402,404,406)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:199822"
     CDS             1..430
                     /gene="SMAD9"
                     /gene_synonym="MADH6; MADH9; PPH2; SMAD8; SMAD8/9; SMAD8A;
                     SMAD8B"
                     /coded_by="XM_047430363.1:3077..4369"
                     /db_xref="GeneID:4093"
                     /db_xref="HGNC:HGNC:6774"
                     /db_xref="MIM:603295"
ORIGIN      
        1 mhsttpissl fsftspavkr llgwkqgdee ekwaekavds lvkklkkkkg amdelerals
       61 cpgqpskcvt iprsldgrlq vshrkglphv iycrvwrwpd lqshhelkpl eccefpfgsk
      121 qkevcinpyh yrrvetpvlp pvlvprhsey npqlsllakf rsaslhsepl mphnatypds
      181 fqqppcsalp pspshafsqs pctasyphsp gspsepespy qhsdfrpvcy eepqhwcsva
      241 yyelnnrvge tfqassrsvl idgftdpsnn rnrfclglls nvnrnstien trrhigkgvh
      301 lyyvggevya ecvsdssifv qsrncnyqhg fhpatvckip sgcslkvfnn qlfaqllaqs
      361 vhhgfevvye ltkmctirms fvkgwgaeyh rqdvtstpcw ieihlhgplq wldkvltqmg
      421 sphnpissvs
//
LOCUS       XP_047286320             430 aa            linear   PRI 05-AUG-2025
DEFINITION  mothers against decapentaplegic homolog 9 isoform X4 [Homo
            sapiens].
ACCESSION   XP_047286320
VERSION     XP_047286320.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430364.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..430
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..430
                     /product="mothers against decapentaplegic homolog 9
                     isoform X4"
                     /calculated_mol_wt=48509
     Region          13..136
                     /region_name="MH1_SMAD_1_5_9"
                     /note="N-terminal Mad Homology 1 (MH1) domain in SMAD1,
                     SMAD5 and SMAD9 (also known as SMAD8); cd10490"
                     /db_xref="CDD:199814"
     Site            order(36,40,74..75,78..82,85,104)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:199814"
     Site            order(68,113,125,130)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:199814"
     Region          230..430
                     /region_name="MH2"
                     /note="C-terminal Mad Homology 2 (MH2) domain; cl00056"
                     /db_xref="CDD:469593"
     Site            order(242,250..251,253,264..268,273,277..280,282,289,
                     293..294,296,369,372,395,402,404,406)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:199822"
     CDS             1..430
                     /gene="SMAD9"
                     /gene_synonym="MADH6; MADH9; PPH2; SMAD8; SMAD8/9; SMAD8A;
                     SMAD8B"
                     /coded_by="XM_047430364.1:2564..3856"
                     /db_xref="GeneID:4093"
                     /db_xref="HGNC:HGNC:6774"
                     /db_xref="MIM:603295"
ORIGIN      
        1 mhsttpissl fsftspavkr llgwkqgdee ekwaekavds lvkklkkkkg amdelerals
       61 cpgqpskcvt iprsldgrlq vshrkglphv iycrvwrwpd lqshhelkpl eccefpfgsk
      121 qkevcinpyh yrrvetpvlp pvlvprhsey npqlsllakf rsaslhsepl mphnatypds
      181 fqqppcsalp pspshafsqs pctasyphsp gspsepespy qhsdfrpvcy eepqhwcsva
      241 yyelnnrvge tfqassrsvl idgftdpsnn rnrfclglls nvnrnstien trrhigkgvh
      301 lyyvggevya ecvsdssifv qsrncnyqhg fhpatvckip sgcslkvfnn qlfaqllaqs
      361 vhhgfevvye ltkmctirms fvkgwgaeyh rqdvtstpcw ieihlhgplq wldkvltqmg
      421 sphnpissvs
//
LOCUS       XP_005266460             393 aa            linear   PRI 05-AUG-2025
DEFINITION  mothers against decapentaplegic homolog 9 isoform X5 [Homo
            sapiens].
ACCESSION   XP_005266460
VERSION     XP_005266460.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266403.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..393
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..393
                     /product="mothers against decapentaplegic homolog 9
                     isoform X5"
                     /calculated_mol_wt=44330
     Region          13..136
                     /region_name="MH1_SMAD_1_5_9"
                     /note="N-terminal Mad Homology 1 (MH1) domain in SMAD1,
                     SMAD5 and SMAD9 (also known as SMAD8); cd10490"
                     /db_xref="CDD:199814"
     Site            order(36,40,74..75,78..82,85,104)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:199814"
     Site            order(68,113,125,130)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:199814"
     Region          181..>334
                     /region_name="MH2"
                     /note="C-terminal Mad Homology 2 (MH2) domain; cl00056"
                     /db_xref="CDD:469593"
     Site            order(193,201..202,204,215..219,224,228..231,233,240,
                     244..245,247,320,323)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:199819"
     CDS             1..393
                     /gene="SMAD9"
                     /gene_synonym="MADH6; MADH9; PPH2; SMAD8; SMAD8/9; SMAD8A;
                     SMAD8B"
                     /coded_by="XM_005266403.4:310..1491"
                     /db_xref="GeneID:4093"
                     /db_xref="HGNC:HGNC:6774"
                     /db_xref="MIM:603295"
ORIGIN      
        1 mhsttpissl fsftspavkr llgwkqgdee ekwaekavds lvkklkkkkg amdelerals
       61 cpgqpskcvt iprsldgrlq vshrkglphv iycrvwrwpd lqshhelkpl eccefpfgsk
      121 qkevcinpyh yrrvetpvdt pplpyhatea setqsgqpvd atadrhvvls ipngdfrpvc
      181 yeepqhwcsv ayyelnnrvg etfqassrsv lidgftdpsn nrnrfclgll snvnrnstie
      241 ntrrhigkgv hlyyvggevy aecvsdssif vqsrncnyqh gfhpatvcki psgcslkvfn
      301 nqlfaqllaq svhhgfevvy eltkmctirm sfvkvamkag eprkflsgke rqlglymevk
      361 afsfitcyfv cckvlaness iskyglikvs gyv
//
LOCUS       XP_047286321             381 aa            linear   PRI 05-AUG-2025
DEFINITION  mothers against decapentaplegic homolog 9 isoform X6 [Homo
            sapiens].
ACCESSION   XP_047286321
VERSION     XP_047286321.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430365.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..381
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..381
                     /product="mothers against decapentaplegic homolog 9
                     isoform X6"
                     /calculated_mol_wt=43050
     Region          13..136
                     /region_name="MH1_SMAD_1_5_9"
                     /note="N-terminal Mad Homology 1 (MH1) domain in SMAD1,
                     SMAD5 and SMAD9 (also known as SMAD8); cd10490"
                     /db_xref="CDD:199814"
     Site            order(36,40,74..75,78..82,85,104)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:199814"
     Site            order(68,113,125,130)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:199814"
     Region          181..381
                     /region_name="MH2"
                     /note="C-terminal Mad Homology 2 (MH2) domain; cl00056"
                     /db_xref="CDD:469593"
     Site            order(193,201..202,204,215..219,224,228..231,233,240,
                     244..245,247,320,323,346,353,355,357)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:199822"
     CDS             1..381
                     /gene="SMAD9"
                     /gene_synonym="MADH6; MADH9; PPH2; SMAD8; SMAD8/9; SMAD8A;
                     SMAD8B"
                     /coded_by="XM_047430365.1:310..1455"
                     /db_xref="GeneID:4093"
                     /db_xref="HGNC:HGNC:6774"
                     /db_xref="MIM:603295"
ORIGIN      
        1 mhsttpissl fsftspavkr llgwkqgdee ekwaekavds lvkklkkkkg amdelerals
       61 cpgqpskcvt iprsldgrlq vshrkglphv iycrvwrwpd lqshhelkpl eccefpfgsk
      121 qkevcinpyh yrrvetpvdt pplpyhatea setqsgqpvd atadrhvvls ipngdfrpvc
      181 yeepqhwcsv ayyelnnrvg etfqassrsv lidgftdpsn nrnrfclgll snvnrnstie
      241 ntrrhigkgv hlyyvggevy aecvsdssif vqsrncnyqh gfhpatvcki psgcslkvfn
      301 nqlfaqllaq svhhgfevvy eltkmctirm sfvkgwgaey hrqdvtstpc wieihlhgpl
      361 qwldkvltqm gsphnpissv s
//
LOCUS       XP_005266461             356 aa            linear   PRI 05-AUG-2025
DEFINITION  mothers against decapentaplegic homolog 9 isoform X7 [Homo
            sapiens].
ACCESSION   XP_005266461
VERSION     XP_005266461.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266404.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..356
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..356
                     /product="mothers against decapentaplegic homolog 9
                     isoform X7"
                     /calculated_mol_wt=40477
     Region          13..136
                     /region_name="MH1_SMAD_1_5_9"
                     /note="N-terminal Mad Homology 1 (MH1) domain in SMAD1,
                     SMAD5 and SMAD9 (also known as SMAD8); cd10490"
                     /db_xref="CDD:199814"
     Site            order(36,40,74..75,78..82,85,104)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:199814"
     Site            order(68,113,125,130)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:199814"
     Region          144..>297
                     /region_name="MH2"
                     /note="C-terminal Mad Homology 2 (MH2) domain; cl00056"
                     /db_xref="CDD:469593"
     Site            order(156,164..165,167,178..182,187,191..194,196,203,
                     207..208,210,283,286)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:199819"
     CDS             1..356
                     /gene="SMAD9"
                     /gene_synonym="MADH6; MADH9; PPH2; SMAD8; SMAD8/9; SMAD8A;
                     SMAD8B"
                     /coded_by="XM_005266404.4:310..1380"
                     /db_xref="GeneID:4093"
                     /db_xref="HGNC:HGNC:6774"
                     /db_xref="MIM:603295"
ORIGIN      
        1 mhsttpissl fsftspavkr llgwkqgdee ekwaekavds lvkklkkkkg amdelerals
       61 cpgqpskcvt iprsldgrlq vshrkglphv iycrvwrwpd lqshhelkpl eccefpfgsk
      121 qkevcinpyh yrrvetpdfr pvcyeepqhw csvayyelnn rvgetfqass rsvlidgftd
      181 psnnrnrfcl gllsnvnrns tientrrhig kgvhlyyvgg evyaecvsds sifvqsrncn
      241 yqhgfhpatv ckipsgcslk vfnnqlfaql laqsvhhgfe vvyeltkmct irmsfvkvam
      301 kageprkfls gkerqlglym evkafsfitc yfvcckvlan essiskygli kvsgyv
//
LOCUS       XP_011533400             621 aa            linear   PRI 05-AUG-2025
DEFINITION  mitochondrial intermediate peptidase isoform X2 [Homo sapiens].
ACCESSION   XP_011533400
VERSION     XP_011533400.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535098.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..621
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..621
                     /product="mitochondrial intermediate peptidase isoform X2"
                     /calculated_mol_wt=69829
     Region          64..619
                     /region_name="M3A_MIP"
                     /note="Peptidase M3 mitochondrial intermediate peptidase
                     (MIP); cd06457"
                     /db_xref="CDD:341052"
     CDS             1..621
                     /gene="MIPEP"
                     /gene_synonym="COXPD31; HMIP; MIP"
                     /coded_by="XM_011535098.4:81..1946"
                     /db_xref="GeneID:4285"
                     /db_xref="HGNC:HGNC:7104"
                     /db_xref="MIM:602241"
ORIGIN      
        1 mlcvgrlggl garaaalppr ragrgsleag irarrvstsw spvgaafnvk pqgsrldlfg
       61 errglfgvpe lsapegfhia qekalrktel lvdracstpp gpqtvlifde lsdslcrvad
      121 ladfvkiahp epafreaaee acrsigtmve klntnvdlyq slqklladkk lvdsldpetr
      181 rvaelfmfdf eisgihldke krkravdlnv kildlsstfl mgtnfpnkie khllpehirr
      241 nftsagdhii idglhaespd dlvreaayki flypnagqlk cleellssrd llaklvgyst
      301 fshralqgti aknpetvmqf leklsdklse rtlkdfemir gmkmklnpqn sevmpwdppy
      361 ysgviraery niepslycpf fslgacmegl nillnrllgi slyaeqpakg evwsedvrkl
      421 avvhesegll gyiycdffqr adkphqdchf tirggrlked gdyqlpvvvl mlnlprssrs
      481 sptlltpsmm enlfhemgha mhsmlgrtry qhvtgtrcpt dfaevpsilm eyfandyrvv
      541 nqfarhyqtg qplpknmvsr lceskkvcaa admqlqvfya tldqiyhgkh plrnsttdil
      601 ketqekfygl pyvpntavqe a
//
LOCUS       XP_047286324             559 aa            linear   PRI 05-AUG-2025
DEFINITION  mitochondrial intermediate peptidase isoform X3 [Homo sapiens].
ACCESSION   XP_047286324
VERSION     XP_047286324.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430368.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..559
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..559
                     /product="mitochondrial intermediate peptidase isoform X3"
                     /calculated_mol_wt=63346
     Region          2..557
                     /region_name="M3A_MIP"
                     /note="Peptidase M3 mitochondrial intermediate peptidase
                     (MIP); cd06457"
                     /db_xref="CDD:341052"
     CDS             1..559
                     /gene="MIPEP"
                     /gene_synonym="COXPD31; HMIP; MIP"
                     /coded_by="XM_047430368.1:721..2400"
                     /db_xref="GeneID:4285"
                     /db_xref="HGNC:HGNC:7104"
                     /db_xref="MIM:602241"
ORIGIN      
        1 mglfgvpels apegfhiaqe kalrktellv dracstppgp qtvlifdels dslcrvadla
       61 dfvkiahpep afreaaeeac rsigtmvekl ntnvdlyqsl qklladkklv dsldpetrrv
      121 aelfmfdfei sgihldkekr kravdlnvki ldlsstflmg tnfpnkiekh llpehirrnf
      181 tsagdhiiid glhaespddl vreaaykifl ypnagqlkcl eellssrdll aklvgystfs
      241 hralqgtiak npetvmqfle klsdklsert lkdfemirgm kmklnpqnse vmpwdppyys
      301 gviraeryni epslycpffs lgacmeglni llnrllgisl yaeqpakgev wsedvrklav
      361 vhesegllgy iycdffqrad kphqdchfti rggrlkedgd yqlpvvvlml nlprssrssp
      421 tlltpsmmen lfhemghamh smlgrtryqh vtgtrcptdf aevpsilmey fandyrvvnq
      481 farhyqtgqp lpknmvsrlc eskkvcaaad mqlqvfyatl dqiyhgkhpl rnsttdilke
      541 tqekfyglpy vpntavqea
//
LOCUS       XP_016876094             744 aa            linear   PRI 05-AUG-2025
DEFINITION  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X1
            [Homo sapiens].
ACCESSION   XP_016876094
VERSION     XP_016876094.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020605.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..744
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..744
                     /product="propionyl-CoA carboxylase alpha chain,
                     mitochondrial isoform X1"
                     /calculated_mol_wt=82091
     Region          63..512
                     /region_name="PccA"
                     /note="Acetyl/propionyl-CoA carboxylase, alpha subunit
                     [Lipid transport and metabolism]; COG4770"
                     /db_xref="CDD:443802"
     Region          525..>615
                     /region_name="PCC_BT"
                     /note="Propionyl-coenzyme A carboxylase BT domain;
                     pfam18140"
                     /db_xref="CDD:465666"
     CDS             1..744
                     /gene="PCCA"
                     /coded_by="XM_017020605.2:29..2263"
                     /db_xref="GeneID:5095"
                     /db_xref="HGNC:HGNC:8653"
                     /db_xref="MIM:232000"
ORIGIN      
        1 magfwvgtap lvaagrrgrw ppqqlmlsaa lrtlkhvlyy srqclmvsrn lgsvgydpne
       61 ktfdkilvan rgeiacrvir tckkmgiktv aihsdvdass vhvkmadeav cvgpaptsks
      121 ylnmdaimea ikktraqavh pgygflsenk efarclaaed vvfigpdtha iqamgdkies
      181 kllakkaevn tipgfdgvvk daeeavriar eigypvmika saggggkgmr iawddeetrd
      241 gfrlssqeaa ssfgddrlli ekfidnprhi eiqvlgdkhg nalwlnerec siqrrnqkvv
      301 eeapsiflda etrramgeqa valaravkys sagtveflvd skknfyflem ntrlqvehpv
      361 tecitgldlv qemirvakgy plrhkqadir ingwavecrv yaedpyksfg lpsigrlsqy
      421 qeplhlpgvr vdsgiqpgsd isiyydpmis klitygsdrt ealkrmadal dnyvirgvth
      481 niallrevii nsrfvkgdis tkflsdvypd gfkghmltks eknqllaias slfvafqlra
      541 qhfqensrmp vikpdianwe lsvklhdkvh tvvasnngsv fsvevdgskl nvtstwnlas
      601 pllsvsvdgt qrtvqevlqv mcrynshavg pvlshscmar pvsfsrsrwk hehsvswysg
      661 argsgkvqhc qlstksvsvi kypmvcgsgt emglfpkals matsvyfcil sciasvayil
      721 vstvygesll ieietaimkp aiin
//
LOCUS       XP_016876095             718 aa            linear   PRI 05-AUG-2025
DEFINITION  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X2
            [Homo sapiens].
ACCESSION   XP_016876095
VERSION     XP_016876095.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020606.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..718
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..718
                     /product="propionyl-CoA carboxylase alpha chain,
                     mitochondrial isoform X2"
                     /calculated_mol_wt=79079
     Region          37..486
                     /region_name="PccA"
                     /note="Acetyl/propionyl-CoA carboxylase, alpha subunit
                     [Lipid transport and metabolism]; COG4770"
                     /db_xref="CDD:443802"
     Region          499..>589
                     /region_name="PCC_BT"
                     /note="Propionyl-coenzyme A carboxylase BT domain;
                     pfam18140"
                     /db_xref="CDD:465666"
     CDS             1..718
                     /gene="PCCA"
                     /coded_by="XM_017020606.2:29..2185"
                     /db_xref="GeneID:5095"
                     /db_xref="HGNC:HGNC:8653"
                     /db_xref="MIM:232000"
ORIGIN      
        1 magfwvgtap lvaagrrgrw ppqqlmlsaa lrtlktfdki lvanrgeiac rvirtckkmg
       61 iktvaihsdv dassvhvkma deavcvgpap tsksylnmda imeaikktra qavhpgygfl
      121 senkefarcl aaedvvfigp dthaiqamgd kieskllakk aevntipgfd gvvkdaeeav
      181 riareigypv mikasagggg kgmriawdde etrdgfrlss qeaassfgdd rlliekfidn
      241 prhieiqvlg dkhgnalwln erecsiqrrn qkvveeapsi fldaetrram geqavalara
      301 vkyssagtve flvdskknfy flemntrlqv ehpvtecitg ldlvqemirv akgyplrhkq
      361 adiringwav ecrvyaedpy ksfglpsigr lsqyqeplhl pgvrvdsgiq pgsdisiyyd
      421 pmisklityg sdrtealkrm adaldnyvir gvthniallr eviinsrfvk gdistkflsd
      481 vypdgfkghm ltkseknqll aiasslfvaf qlraqhfqen srmpvikpdi anwelsvklh
      541 dkvhtvvasn ngsvfsvevd gsklnvtstw nlaspllsvs vdgtqrtvqe vlqvmcryns
      601 havgpvlshs cmarpvsfsr srwkhehsvs wysgargsgk vqhcqlstks vsvikypmvc
      661 gsgtemglfp kalsmatsvy fcilsciasv ayilvstvyg esllieieta imkpaiin
//
LOCUS       XP_016876096             711 aa            linear   PRI 05-AUG-2025
DEFINITION  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X3
            [Homo sapiens].
ACCESSION   XP_016876096
VERSION     XP_016876096.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020607.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..711
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..711
                     /product="propionyl-CoA carboxylase alpha chain,
                     mitochondrial isoform X3"
                     /calculated_mol_wt=78561
     Region          30..479
                     /region_name="PccA"
                     /note="Acetyl/propionyl-CoA carboxylase, alpha subunit
                     [Lipid transport and metabolism]; COG4770"
                     /db_xref="CDD:443802"
     Region          492..>582
                     /region_name="PCC_BT"
                     /note="Propionyl-coenzyme A carboxylase BT domain;
                     pfam18140"
                     /db_xref="CDD:465666"
     CDS             1..711
                     /gene="PCCA"
                     /coded_by="XM_017020607.2:1168..3303"
                     /db_xref="GeneID:5095"
                     /db_xref="HGNC:HGNC:8653"
                     /db_xref="MIM:232000"
ORIGIN      
        1 mehvlyysrq clmvsrnlgs vgydpnektf dkilvanrge iacrvirtck kmgiktvaih
       61 sdvdassvhv kmadeavcvg paptsksyln mdaimeaikk traqavhpgy gflsenkefa
      121 rclaaedvvf igpdthaiqa mgdkieskll akkaevntip gfdgvvkdae eavriareig
      181 ypvmikasag gggkgmriaw ddeetrdgfr lssqeaassf gddrlliekf idnprhieiq
      241 vlgdkhgnal wlnerecsiq rrnqkvveea psifldaetr ramgeqaval aravkyssag
      301 tveflvdskk nfyflemntr lqvehpvtec itgldlvqem irvakgyplr hkqadiring
      361 wavecrvyae dpyksfglps igrlsqyqep lhlpgvrvds giqpgsdisi yydpmiskli
      421 tygsdrteal krmadaldny virgvthnia llreviinsr fvkgdistkf lsdvypdgfk
      481 ghmltksekn qllaiasslf vafqlraqhf qensrmpvik pdianwelsv klhdkvhtvv
      541 asnngsvfsv evdgsklnvt stwnlaspll svsvdgtqrt vqevlqvmcr ynshavgpvl
      601 shscmarpvs fsrsrwkheh svswysgarg sgkvqhcqls tksvsvikyp mvcgsgtemg
      661 lfpkalsmat svyfcilsci asvayilvst vygeslliei etaimkpaii n
//
LOCUS       XP_011519395             699 aa            linear   PRI 05-AUG-2025
DEFINITION  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X4
            [Homo sapiens].
ACCESSION   XP_011519395
VERSION     XP_011519395.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521093.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..699
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..699
                     /product="propionyl-CoA carboxylase alpha chain,
                     mitochondrial isoform X4"
                     /calculated_mol_wt=77048
     Region          63..512
                     /region_name="PccA"
                     /note="Acetyl/propionyl-CoA carboxylase, alpha subunit
                     [Lipid transport and metabolism]; COG4770"
                     /db_xref="CDD:443802"
     Region          525..633
                     /region_name="PCC_BT"
                     /note="Propionyl-coenzyme A carboxylase BT domain;
                     pfam18140"
                     /db_xref="CDD:465666"
     CDS             1..699
                     /gene="PCCA"
                     /coded_by="XM_011521093.2:29..2128"
                     /db_xref="GeneID:5095"
                     /db_xref="HGNC:HGNC:8653"
                     /db_xref="MIM:232000"
ORIGIN      
        1 magfwvgtap lvaagrrgrw ppqqlmlsaa lrtlkhvlyy srqclmvsrn lgsvgydpne
       61 ktfdkilvan rgeiacrvir tckkmgiktv aihsdvdass vhvkmadeav cvgpaptsks
      121 ylnmdaimea ikktraqavh pgygflsenk efarclaaed vvfigpdtha iqamgdkies
      181 kllakkaevn tipgfdgvvk daeeavriar eigypvmika saggggkgmr iawddeetrd
      241 gfrlssqeaa ssfgddrlli ekfidnprhi eiqvlgdkhg nalwlnerec siqrrnqkvv
      301 eeapsiflda etrramgeqa valaravkys sagtveflvd skknfyflem ntrlqvehpv
      361 tecitgldlv qemirvakgy plrhkqadir ingwavecrv yaedpyksfg lpsigrlsqy
      421 qeplhlpgvr vdsgiqpgsd isiyydpmis klitygsdrt ealkrmadal dnyvirgvth
      481 niallrevii nsrfvkgdis tkflsdvypd gfkghmltks eknqllaias slfvafqlra
      541 qhfqensrmp vikpdianwe lsvklhdkvh tvvasnngsv fsvevdgskl nvtstwnlas
      601 pllsvsvdgt qrtvqclsre aggnmsiqfl gtvehgaqgk fsivscqqnh pgesfwidce
      661 klgrrccglv agsagglglk alglyklfwi cntfilnlq
//
LOCUS       XP_016876098             695 aa            linear   PRI 05-AUG-2025
DEFINITION  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X5
            [Homo sapiens].
ACCESSION   XP_016876098
VERSION     XP_016876098.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020609.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..695
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..695
                     /product="propionyl-CoA carboxylase alpha chain,
                     mitochondrial isoform X5"
                     /calculated_mol_wt=76398
     Region          30..479
                     /region_name="PccA"
                     /note="Acetyl/propionyl-CoA carboxylase, alpha subunit
                     [Lipid transport and metabolism]; COG4770"
                     /db_xref="CDD:443802"
     Region          492..620
                     /region_name="PCC_BT"
                     /note="Propionyl-coenzyme A carboxylase BT domain;
                     pfam18140"
                     /db_xref="CDD:465666"
     Region          628..694
                     /region_name="biotinyl_domain"
                     /note="The biotinyl-domain or biotin carboxyl carrier
                     protein (BCCP) domain is present in all biotin-dependent
                     enzymes, such as acetyl-CoA carboxylase, pyruvate
                     carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA
                     carboxylase, geranyl-CoA carboxylase; cd06850"
                     /db_xref="CDD:133459"
     Site            order(651,660..662,669)
                     /site_type="active"
                     /note="carboxyltransferase (CT) interaction site [active]"
                     /db_xref="CDD:133459"
     Site            661
                     /site_type="other"
                     /note="biotinylation site [posttranslational
                     modification]"
                     /db_xref="CDD:133459"
     CDS             1..695
                     /gene="PCCA"
                     /coded_by="XM_017020609.2:1168..3255"
                     /db_xref="GeneID:5095"
                     /db_xref="HGNC:HGNC:8653"
                     /db_xref="MIM:232000"
ORIGIN      
        1 mehvlyysrq clmvsrnlgs vgydpnektf dkilvanrge iacrvirtck kmgiktvaih
       61 sdvdassvhv kmadeavcvg paptsksyln mdaimeaikk traqavhpgy gflsenkefa
      121 rclaaedvvf igpdthaiqa mgdkieskll akkaevntip gfdgvvkdae eavriareig
      181 ypvmikasag gggkgmriaw ddeetrdgfr lssqeaassf gddrlliekf idnprhieiq
      241 vlgdkhgnal wlnerecsiq rrnqkvveea psifldaetr ramgeqaval aravkyssag
      301 tveflvdskk nfyflemntr lqvehpvtec itgldlvqem irvakgyplr hkqadiring
      361 wavecrvyae dpyksfglps igrlsqyqep lhlpgvrvds giqpgsdisi yydpmiskli
      421 tygsdrteal krmadaldny virgvthnia llreviinsr fvkgdistkf lsdvypdgfk
      481 ghmltksekn qllaiasslf vafqlraqhf qensrmpvik pdianwelsv klhdkvhtvv
      541 asnngsvfsv evdgsklnvt stwnlaspll svsvdgtqrt vqclsreagg nmsiqflgtv
      601 ykvniltrla aelnkfmlek vtedtssvlr spmpgvvvav svkpgdavae gqeicvieam
      661 kmqnsmtagk tgtvksvhcq agdtvgegdl lvele
//
LOCUS       XP_047286326             689 aa            linear   PRI 05-AUG-2025
DEFINITION  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X6
            [Homo sapiens].
ACCESSION   XP_047286326
VERSION     XP_047286326.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430370.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..689
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..689
                     /product="propionyl-CoA carboxylase alpha chain,
                     mitochondrial isoform X6"
                     /calculated_mol_wt=76142
     Region          47..457
                     /region_name="PccA"
                     /note="Acetyl/propionyl-CoA carboxylase, alpha subunit
                     [Lipid transport and metabolism]; COG4770"
                     /db_xref="CDD:443802"
     Region          470..580
                     /region_name="PCC_BT"
                     /note="Propionyl-coenzyme A carboxylase BT domain;
                     pfam18140"
                     /db_xref="CDD:465666"
     CDS             1..689
                     /gene="PCCA"
                     /coded_by="XM_047430370.1:535..2604"
                     /db_xref="GeneID:5095"
                     /db_xref="HGNC:HGNC:8653"
                     /db_xref="MIM:232000"
ORIGIN      
        1 mlcrdthcip pfspsnypnf lgsllrtghe csllkywatl atcnkvhvkm adeavcvgpa
       61 ptsksylnmd aimeaikktr aqavhpgygf lsenkefarc laaedvvfig pdthaiqamg
      121 dkieskllak kaevntipgf dgvvkdaeea vriareigyp vmikasaggg gkgmriawdd
      181 eetrdgfrls sqeaassfgd drlliekfid nprhieiqvl gdkhgnalwl nerecsiqrr
      241 nqkvveeaps ifldaetrra mgeqavalar avkyssagtv eflvdskknf yflemntrlq
      301 vehpvtecit gldlvqemir vakgyplrhk qadiringwa vecrvyaedp yksfglpsig
      361 rlsqyqeplh lpgvrvdsgi qpgsdisiyy dpmisklity gsdrtealkr madaldnyvi
      421 rgvthniall reviinsrfv kgdistkfls dvypdgfkgh mltkseknql laiasslfva
      481 fqlraqhfqe nsrmpvikpd ianwelsvkl hdkvhtvvas nngsvfsvev dgsklnvtst
      541 wnlaspllsv svdgtqrtvq evlqvmcryn shavgpvlsh scmarpvsfs rsrwkhehsv
      601 swysgargsg kvqhcqlstk svsvikypmv cgsgtemglf pkalsmatsv yfcilscias
      661 vayilvstvy gesllieiet aimkpaiin
//
LOCUS       XP_047286327             684 aa            linear   PRI 05-AUG-2025
DEFINITION  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X7
            [Homo sapiens].
ACCESSION   XP_047286327
VERSION     XP_047286327.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430371.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..684
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..684
                     /product="propionyl-CoA carboxylase alpha chain,
                     mitochondrial isoform X7"
                     /calculated_mol_wt=75052
     Region          37..486
                     /region_name="PccA"
                     /note="Acetyl/propionyl-CoA carboxylase, alpha subunit
                     [Lipid transport and metabolism]; COG4770"
                     /db_xref="CDD:443802"
     Region          499..609
                     /region_name="PCC_BT"
                     /note="Propionyl-coenzyme A carboxylase BT domain;
                     pfam18140"
                     /db_xref="CDD:465666"
     Region          617..683
                     /region_name="biotinyl_domain"
                     /note="The biotinyl-domain or biotin carboxyl carrier
                     protein (BCCP) domain is present in all biotin-dependent
                     enzymes, such as acetyl-CoA carboxylase, pyruvate
                     carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA
                     carboxylase, geranyl-CoA carboxylase; cd06850"
                     /db_xref="CDD:133459"
     Site            order(640,649..651,658)
                     /site_type="active"
                     /note="carboxyltransferase (CT) interaction site [active]"
                     /db_xref="CDD:133459"
     Site            650
                     /site_type="other"
                     /note="biotinylation site [posttranslational
                     modification]"
                     /db_xref="CDD:133459"
     CDS             1..684
                     /gene="PCCA"
                     /coded_by="XM_047430371.1:29..2083"
                     /db_xref="GeneID:5095"
                     /db_xref="HGNC:HGNC:8653"
                     /db_xref="MIM:232000"
ORIGIN      
        1 magfwvgtap lvaagrrgrw ppqqlmlsaa lrtlktfdki lvanrgeiac rvirtckkmg
       61 iktvaihsdv dassvhvkma deavcvgpap tsksylnmda imeaikktra qavhpgygfl
      121 senkefarcl aaedvvfigp dthaiqamgd kieskllakk aevntipgfd gvvkdaeeav
      181 riareigypv mikasagggg kgmriawdde etrdgfrlss qeaassfgdd rlliekfidn
      241 prhieiqvlg dkhgnalwln erecsiqrrn qkvveeapsi fldaetrram geqavalara
      301 vkyssagtve flvdskknfy flemntrlqv ehpvtecitg ldlvqemirv akgyplrhkq
      361 adiringwav ecrvyaedpy ksfglpsigr lsqyqeplhl pgvrvdsgiq pgsdisiyyd
      421 pmisklityg sdrtealkrm adaldnyvir gvthniallr eviinsrfvk gdistkflsd
      481 vypdgfkghm ltkseknqll aiasslfvaf qlraqhfqen srmpvikpdi anwelsvklh
      541 dkvhtvvasn ngsvfsvevd gsklnvtstw nlaspllsvs vdgtqrtvqy kvniltrlaa
      601 elnkfmlekv tedtssvlrs pmpgvvvavs vkpgdavaeg qeicvieamk mqnsmtagkt
      661 gtvksvhcqa gdtvgegdll vele
//
LOCUS       XP_016876100             683 aa            linear   PRI 05-AUG-2025
DEFINITION  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X8
            [Homo sapiens].
ACCESSION   XP_016876100
VERSION     XP_016876100.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020611.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..683
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..683
                     /product="propionyl-CoA carboxylase alpha chain,
                     mitochondrial isoform X8"
                     /calculated_mol_wt=75765
     Region          63..512
                     /region_name="PccA"
                     /note="Acetyl/propionyl-CoA carboxylase, alpha subunit
                     [Lipid transport and metabolism]; COG4770"
                     /db_xref="CDD:443802"
     Region          525..>615
                     /region_name="PCC_BT"
                     /note="Propionyl-coenzyme A carboxylase BT domain;
                     pfam18140"
                     /db_xref="CDD:465666"
     CDS             1..683
                     /gene="PCCA"
                     /coded_by="XM_017020611.2:29..2080"
                     /db_xref="GeneID:5095"
                     /db_xref="HGNC:HGNC:8653"
                     /db_xref="MIM:232000"
ORIGIN      
        1 magfwvgtap lvaagrrgrw ppqqlmlsaa lrtlkhvlyy srqclmvsrn lgsvgydpne
       61 ktfdkilvan rgeiacrvir tckkmgiktv aihsdvdass vhvkmadeav cvgpaptsks
      121 ylnmdaimea ikktraqavh pgygflsenk efarclaaed vvfigpdtha iqamgdkies
      181 kllakkaevn tipgfdgvvk daeeavriar eigypvmika saggggkgmr iawddeetrd
      241 gfrlssqeaa ssfgddrlli ekfidnprhi eiqvlgdkhg nalwlnerec siqrrnqkvv
      301 eeapsiflda etrramgeqa valaravkys sagtveflvd skknfyflem ntrlqvehpv
      361 tecitgldlv qemirvakgy plrhkqadir ingwavecrv yaedpyksfg lpsigrlsqy
      421 qeplhlpgvr vdsgiqpgsd isiyydpmis klitygsdrt ealkrmadal dnyvirgvth
      481 niallrevii nsrfvkgdis tkflsdvypd gfkghmltks eknqllaias slfvafqlra
      541 qhfqensrmp vikpdianwe lsvklhdkvh tvvasnngsv fsvevdgskl nvtstwnlas
      601 pllsvsvdgt qrtvqevlqv mcrynshavg pvlshscmar pvsfsrsrwk hehsvswysg
      661 argsgkvqhc qlstkspwrk lld
//
LOCUS       XP_016876101             681 aa            linear   PRI 05-AUG-2025
DEFINITION  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X9
            [Homo sapiens].
ACCESSION   XP_016876101
VERSION     XP_016876101.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020612.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..681
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..681
                     /product="propionyl-CoA carboxylase alpha chain,
                     mitochondrial isoform X9"
                     /calculated_mol_wt=75684
     Region          63..512
                     /region_name="PccA"
                     /note="Acetyl/propionyl-CoA carboxylase, alpha subunit
                     [Lipid transport and metabolism]; COG4770"
                     /db_xref="CDD:443802"
     Region          525..>615
                     /region_name="PCC_BT"
                     /note="Propionyl-coenzyme A carboxylase BT domain;
                     pfam18140"
                     /db_xref="CDD:465666"
     CDS             1..681
                     /gene="PCCA"
                     /coded_by="XM_017020612.2:29..2074"
                     /db_xref="GeneID:5095"
                     /db_xref="HGNC:HGNC:8653"
                     /db_xref="MIM:232000"
ORIGIN      
        1 magfwvgtap lvaagrrgrw ppqqlmlsaa lrtlkhvlyy srqclmvsrn lgsvgydpne
       61 ktfdkilvan rgeiacrvir tckkmgiktv aihsdvdass vhvkmadeav cvgpaptsks
      121 ylnmdaimea ikktraqavh pgygflsenk efarclaaed vvfigpdtha iqamgdkies
      181 kllakkaevn tipgfdgvvk daeeavriar eigypvmika saggggkgmr iawddeetrd
      241 gfrlssqeaa ssfgddrlli ekfidnprhi eiqvlgdkhg nalwlnerec siqrrnqkvv
      301 eeapsiflda etrramgeqa valaravkys sagtveflvd skknfyflem ntrlqvehpv
      361 tecitgldlv qemirvakgy plrhkqadir ingwavecrv yaedpyksfg lpsigrlsqy
      421 qeplhlpgvr vdsgiqpgsd isiyydpmis klitygsdrt ealkrmadal dnyvirgvth
      481 niallrevii nsrfvkgdis tkflsdvypd gfkghmltks eknqllaias slfvafqlra
      541 qhfqensrmp vikpdianwe lsvklhdkvh tvvasnngsv fsvevdgskl nvtstwnlas
      601 pllsvsvdgt qrtvqevlqv mcrynshavg pvlshscmar pvsfsrsrwk hehsvswysv
      661 qgeylnqtcr rieqiyagks d
//
LOCUS       XP_047286328             673 aa            linear   PRI 05-AUG-2025
DEFINITION  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X10
            [Homo sapiens].
ACCESSION   XP_047286328
VERSION     XP_047286328.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430372.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..673
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..673
                     /product="propionyl-CoA carboxylase alpha chain,
                     mitochondrial isoform X10"
                     /calculated_mol_wt=74036
     Region          37..486
                     /region_name="PccA"
                     /note="Acetyl/propionyl-CoA carboxylase, alpha subunit
                     [Lipid transport and metabolism]; COG4770"
                     /db_xref="CDD:443802"
     Region          499..607
                     /region_name="PCC_BT"
                     /note="Propionyl-coenzyme A carboxylase BT domain;
                     pfam18140"
                     /db_xref="CDD:465666"
     CDS             1..673
                     /gene="PCCA"
                     /coded_by="XM_047430372.1:29..2050"
                     /db_xref="GeneID:5095"
                     /db_xref="HGNC:HGNC:8653"
                     /db_xref="MIM:232000"
ORIGIN      
        1 magfwvgtap lvaagrrgrw ppqqlmlsaa lrtlktfdki lvanrgeiac rvirtckkmg
       61 iktvaihsdv dassvhvkma deavcvgpap tsksylnmda imeaikktra qavhpgygfl
      121 senkefarcl aaedvvfigp dthaiqamgd kieskllakk aevntipgfd gvvkdaeeav
      181 riareigypv mikasagggg kgmriawdde etrdgfrlss qeaassfgdd rlliekfidn
      241 prhieiqvlg dkhgnalwln erecsiqrrn qkvveeapsi fldaetrram geqavalara
      301 vkyssagtve flvdskknfy flemntrlqv ehpvtecitg ldlvqemirv akgyplrhkq
      361 adiringwav ecrvyaedpy ksfglpsigr lsqyqeplhl pgvrvdsgiq pgsdisiyyd
      421 pmisklityg sdrtealkrm adaldnyvir gvthniallr eviinsrfvk gdistkflsd
      481 vypdgfkghm ltkseknqll aiasslfvaf qlraqhfqen srmpvikpdi anwelsvklh
      541 dkvhtvvasn ngsvfsvevd gsklnvtstw nlaspllsvs vdgtqrtvqc lsreaggnms
      601 iqflgtvehg aqgkfsivsc qqnhpgesfw idceklgrrc cglvagsagg lglkalglyk
      661 lfwicntfil nlq
//
LOCUS       XP_016876102             669 aa            linear   PRI 05-AUG-2025
DEFINITION  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X11
            [Homo sapiens].
ACCESSION   XP_016876102
VERSION     XP_016876102.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020613.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..669
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..669
                     /product="propionyl-CoA carboxylase alpha chain,
                     mitochondrial isoform X11"
                     /calculated_mol_wt=74275
     Region          63..512
                     /region_name="PccA"
                     /note="Acetyl/propionyl-CoA carboxylase, alpha subunit
                     [Lipid transport and metabolism]; COG4770"
                     /db_xref="CDD:443802"
     Region          525..>615
                     /region_name="PCC_BT"
                     /note="Propionyl-coenzyme A carboxylase BT domain;
                     pfam18140"
                     /db_xref="CDD:465666"
     CDS             1..669
                     /gene="PCCA"
                     /coded_by="XM_017020613.2:29..2038"
                     /db_xref="GeneID:5095"
                     /db_xref="HGNC:HGNC:8653"
                     /db_xref="MIM:232000"
ORIGIN      
        1 magfwvgtap lvaagrrgrw ppqqlmlsaa lrtlkhvlyy srqclmvsrn lgsvgydpne
       61 ktfdkilvan rgeiacrvir tckkmgiktv aihsdvdass vhvkmadeav cvgpaptsks
      121 ylnmdaimea ikktraqavh pgygflsenk efarclaaed vvfigpdtha iqamgdkies
      181 kllakkaevn tipgfdgvvk daeeavriar eigypvmika saggggkgmr iawddeetrd
      241 gfrlssqeaa ssfgddrlli ekfidnprhi eiqvlgdkhg nalwlnerec siqrrnqkvv
      301 eeapsiflda etrramgeqa valaravkys sagtveflvd skknfyflem ntrlqvehpv
      361 tecitgldlv qemirvakgy plrhkqadir ingwavecrv yaedpyksfg lpsigrlsqy
      421 qeplhlpgvr vdsgiqpgsd isiyydpmis klitygsdrt ealkrmadal dnyvirgvth
      481 niallrevii nsrfvkgdis tkflsdvypd gfkghmltks eknqllaias slfvafqlra
      541 qhfqensrmp vikpdianwe lsvklhdkvh tvvasnngsv fsvevdgskl nvtstwnlas
      601 pllsvsvdgt qrtvqevlqv mcrynshavg pvlshscmar pvsfsrsrwk hehsvswysg
      661 srrsrnlcd
//
LOCUS       XP_047286329             648 aa            linear   PRI 05-AUG-2025
DEFINITION  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X12
            [Homo sapiens].
ACCESSION   XP_047286329
VERSION     XP_047286329.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430373.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..648
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..648
                     /product="propionyl-CoA carboxylase alpha chain,
                     mitochondrial isoform X12"
                     /calculated_mol_wt=71341
     Region          30..479
                     /region_name="PccA"
                     /note="Acetyl/propionyl-CoA carboxylase, alpha subunit
                     [Lipid transport and metabolism]; COG4770"
                     /db_xref="CDD:443802"
     Region          492..601
                     /region_name="PCC_BT"
                     /note="Propionyl-coenzyme A carboxylase BT domain;
                     pfam18140"
                     /db_xref="CDD:465666"
     Region          <598..647
                     /region_name="biotinyl_domain"
                     /note="The biotinyl-domain or biotin carboxyl carrier
                     protein (BCCP) domain is present in all biotin-dependent
                     enzymes, such as acetyl-CoA carboxylase, pyruvate
                     carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA
                     carboxylase, geranyl-CoA carboxylase; cd06850"
                     /db_xref="CDD:133459"
     Site            order(604,613..615,622)
                     /site_type="active"
                     /note="carboxyltransferase (CT) interaction site [active]"
                     /db_xref="CDD:133459"
     Site            614
                     /site_type="other"
                     /note="biotinylation site [posttranslational
                     modification]"
                     /db_xref="CDD:133459"
     CDS             1..648
                     /gene="PCCA"
                     /coded_by="XM_047430373.1:1168..3114"
                     /db_xref="GeneID:5095"
                     /db_xref="HGNC:HGNC:8653"
                     /db_xref="MIM:232000"
ORIGIN      
        1 mehvlyysrq clmvsrnlgs vgydpnektf dkilvanrge iacrvirtck kmgiktvaih
       61 sdvdassvhv kmadeavcvg paptsksyln mdaimeaikk traqavhpgy gflsenkefa
      121 rclaaedvvf igpdthaiqa mgdkieskll akkaevntip gfdgvvkdae eavriareig
      181 ypvmikasag gggkgmriaw ddeetrdgfr lssqeaassf gddrlliekf idnprhieiq
      241 vlgdkhgnal wlnerecsiq rrnqkvveea psifldaetr ramgeqaval aravkyssag
      301 tveflvdskk nfyflemntr lqvehpvtec itgldlvqem irvakgyplr hkqadiring
      361 wavecrvyae dpyksfglps igrlsqyqep lhlpgvrvds giqpgsdisi yydpmiskli
      421 tygsdrteal krmadaldny virgvthnia llreviinsr fvkgdistkf lsdvypdgfk
      481 ghmltksekn qllaiasslf vafqlraqhf qensrmpvik pdianwelsv klhdkvhtvv
      541 asnngsvfsv evdgsklnvt stwnlaspll svsvdgtqrt vqclsreagg nmsiqflgtv
      601 vaegqeicvi eamkmqnsmt agktgtvksv hcqagdtvge gdllvele
//
LOCUS       XP_047286330             640 aa            linear   PRI 05-AUG-2025
DEFINITION  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X13
            [Homo sapiens].
ACCESSION   XP_047286330
VERSION     XP_047286330.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430374.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..640
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..640
                     /product="propionyl-CoA carboxylase alpha chain,
                     mitochondrial isoform X13"
                     /calculated_mol_wt=70717
     Region          63..512
                     /region_name="PccA"
                     /note="Acetyl/propionyl-CoA carboxylase, alpha subunit
                     [Lipid transport and metabolism]; COG4770"
                     /db_xref="CDD:443802"
     Region          525..>581
                     /region_name="PCC_BT"
                     /note="Propionyl-coenzyme A carboxylase BT domain;
                     pfam18140"
                     /db_xref="CDD:465666"
     CDS             1..640
                     /gene="PCCA"
                     /coded_by="XM_047430374.1:29..1951"
                     /db_xref="GeneID:5095"
                     /db_xref="HGNC:HGNC:8653"
                     /db_xref="MIM:232000"
ORIGIN      
        1 magfwvgtap lvaagrrgrw ppqqlmlsaa lrtlkhvlyy srqclmvsrn lgsvgydpne
       61 ktfdkilvan rgeiacrvir tckkmgiktv aihsdvdass vhvkmadeav cvgpaptsks
      121 ylnmdaimea ikktraqavh pgygflsenk efarclaaed vvfigpdtha iqamgdkies
      181 kllakkaevn tipgfdgvvk daeeavriar eigypvmika saggggkgmr iawddeetrd
      241 gfrlssqeaa ssfgddrlli ekfidnprhi eiqvlgdkhg nalwlnerec siqrrnqkvv
      301 eeapsiflda etrramgeqa valaravkys sagtveflvd skknfyflem ntrlqvehpv
      361 tecitgldlv qemirvakgy plrhkqadir ingwavecrv yaedpyksfg lpsigrlsqy
      421 qeplhlpgvr vdsgiqpgsd isiyydpmis klitygsdrt ealkrmadal dnyvirgvth
      481 niallrevii nsrfvkgdis tkflsdvypd gfkghmltks eknqllaias slfvafqlra
      541 qhfqensrmp vikpdianwe lsvklhdkvh tvvasnngsv fsnifgrshk klgpmvacel
      601 gswradsitk tsavtwpsge airkaagsln gecwshrcgs
//
LOCUS       XP_016876104             624 aa            linear   PRI 05-AUG-2025
DEFINITION  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X14
            [Homo sapiens].
ACCESSION   XP_016876104
VERSION     XP_016876104.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020615.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..624
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..624
                     /product="propionyl-CoA carboxylase alpha chain,
                     mitochondrial isoform X14"
                     /calculated_mol_wt=69207
     Region          63..512
                     /region_name="PccA"
                     /note="Acetyl/propionyl-CoA carboxylase, alpha subunit
                     [Lipid transport and metabolism]; COG4770"
                     /db_xref="CDD:443802"
     Region          525..>581
                     /region_name="PCC_BT"
                     /note="Propionyl-coenzyme A carboxylase BT domain;
                     pfam18140"
                     /db_xref="CDD:465666"
     CDS             1..624
                     /gene="PCCA"
                     /coded_by="XM_017020615.2:29..1903"
                     /db_xref="GeneID:5095"
                     /db_xref="HGNC:HGNC:8653"
                     /db_xref="MIM:232000"
ORIGIN      
        1 magfwvgtap lvaagrrgrw ppqqlmlsaa lrtlkhvlyy srqclmvsrn lgsvgydpne
       61 ktfdkilvan rgeiacrvir tckkmgiktv aihsdvdass vhvkmadeav cvgpaptsks
      121 ylnmdaimea ikktraqavh pgygflsenk efarclaaed vvfigpdtha iqamgdkies
      181 kllakkaevn tipgfdgvvk daeeavriar eigypvmika saggggkgmr iawddeetrd
      241 gfrlssqeaa ssfgddrlli ekfidnprhi eiqvlgdkhg nalwlnerec siqrrnqkvv
      301 eeapsiflda etrramgeqa valaravkys sagtveflvd skknfyflem ntrlqvehpv
      361 tecitgldlv qemirvakgy plrhkqadir ingwavecrv yaedpyksfg lpsigrlsqy
      421 qeplhlpgvr vdsgiqpgsd isiyydpmis klitygsdrt ealkrmadal dnyvirgvth
      481 niallrevii nsrfvkgdis tkflsdvypd gfkghmltks eknqllaias slfvafqlra
      541 qhfqensrmp vikpdianwe lsvklhdkvh tvvasnngsv fsnifgrshk klgpmvacel
      601 gswradsitm egsvrwssve imep
//
LOCUS       XP_047286331             614 aa            linear   PRI 05-AUG-2025
DEFINITION  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X15
            [Homo sapiens].
ACCESSION   XP_047286331
VERSION     XP_047286331.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430375.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..614
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..614
                     /product="propionyl-CoA carboxylase alpha chain,
                     mitochondrial isoform X15"
                     /calculated_mol_wt=67778
     Region          37..486
                     /region_name="PccA"
                     /note="Acetyl/propionyl-CoA carboxylase, alpha subunit
                     [Lipid transport and metabolism]; COG4770"
                     /db_xref="CDD:443802"
     Region          499..607
                     /region_name="PCC_BT"
                     /note="Propionyl-coenzyme A carboxylase BT domain;
                     pfam18140"
                     /db_xref="CDD:465666"
     CDS             1..614
                     /gene="PCCA"
                     /coded_by="XM_047430375.1:29..1873"
                     /db_xref="GeneID:5095"
                     /db_xref="HGNC:HGNC:8653"
                     /db_xref="MIM:232000"
ORIGIN      
        1 magfwvgtap lvaagrrgrw ppqqlmlsaa lrtlktfdki lvanrgeiac rvirtckkmg
       61 iktvaihsdv dassvhvkma deavcvgpap tsksylnmda imeaikktra qavhpgygfl
      121 senkefarcl aaedvvfigp dthaiqamgd kieskllakk aevntipgfd gvvkdaeeav
      181 riareigypv mikasagggg kgmriawdde etrdgfrlss qeaassfgdd rlliekfidn
      241 prhieiqvlg dkhgnalwln erecsiqrrn qkvveeapsi fldaetrram geqavalara
      301 vkyssagtve flvdskknfy flemntrlqv ehpvtecitg ldlvqemirv akgyplrhkq
      361 adiringwav ecrvyaedpy ksfglpsigr lsqyqeplhl pgvrvdsgiq pgsdisiyyd
      421 pmisklityg sdrtealkrm adaldnyvir gvthniallr eviinsrfvk gdistkflsd
      481 vypdgfkghm ltkseknqll aiasslfvaf qlraqhfqen srmpvikpdi anwelsvklh
      541 dkvhtvvasn ngsvfsvevd gsklnvtstw nlaspllsvs vdgtqrtvqc lsreaggnms
      601 iqflgtvpwr klld
//
LOCUS       XP_016876105             551 aa            linear   PRI 05-AUG-2025
DEFINITION  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X16
            [Homo sapiens].
ACCESSION   XP_016876105
VERSION     XP_016876105.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020616.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..551
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..551
                     /product="propionyl-CoA carboxylase alpha chain,
                     mitochondrial isoform X16"
                     /calculated_mol_wt=61020
     Region          63..512
                     /region_name="PccA"
                     /note="Acetyl/propionyl-CoA carboxylase, alpha subunit
                     [Lipid transport and metabolism]; COG4770"
                     /db_xref="CDD:443802"
     CDS             1..551
                     /gene="PCCA"
                     /coded_by="XM_017020616.2:29..1684"
                     /db_xref="GeneID:5095"
                     /db_xref="HGNC:HGNC:8653"
                     /db_xref="MIM:232000"
ORIGIN      
        1 magfwvgtap lvaagrrgrw ppqqlmlsaa lrtlkhvlyy srqclmvsrn lgsvgydpne
       61 ktfdkilvan rgeiacrvir tckkmgiktv aihsdvdass vhvkmadeav cvgpaptsks
      121 ylnmdaimea ikktraqavh pgygflsenk efarclaaed vvfigpdtha iqamgdkies
      181 kllakkaevn tipgfdgvvk daeeavriar eigypvmika saggggkgmr iawddeetrd
      241 gfrlssqeaa ssfgddrlli ekfidnprhi eiqvlgdkhg nalwlnerec siqrrnqkvv
      301 eeapsiflda etrramgeqa valaravkys sagtveflvd skknfyflem ntrlqvehpv
      361 tecitgldlv qemirvakgy plrhkqadir ingwavecrv yaedpyksfg lpsigrlsqy
      421 qeplhlpgvr vdsgiqpgsd isiyydpmis klitygsdrt ealkrmadal dnyvirgvth
      481 niallrevii nsrfvkgdis tkflsdvypd gfkghmltks eknqllaias slfvafqlra
      541 qhfqenssca v
//
LOCUS       XP_047286332             528 aa            linear   PRI 05-AUG-2025
DEFINITION  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X17
            [Homo sapiens].
ACCESSION   XP_047286332
VERSION     XP_047286332.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430376.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..528
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..528
                     /product="propionyl-CoA carboxylase alpha chain,
                     mitochondrial isoform X17"
                     /calculated_mol_wt=58575
     Region          <1..296
                     /region_name="PccA"
                     /note="Acetyl/propionyl-CoA carboxylase, alpha subunit
                     [Lipid transport and metabolism]; COG4770"
                     /db_xref="CDD:443802"
     Region          309..>399
                     /region_name="PCC_BT"
                     /note="Propionyl-coenzyme A carboxylase BT domain;
                     pfam18140"
                     /db_xref="CDD:465666"
     CDS             1..528
                     /gene="PCCA"
                     /coded_by="XM_047430376.1:227..1813"
                     /db_xref="GeneID:5095"
                     /db_xref="HGNC:HGNC:8653"
                     /db_xref="MIM:232000"
ORIGIN      
        1 mikasagggg kgmriawdde etrdgfrlss qeaassfgdd rlliekfidn prhieiqvlg
       61 dkhgnalwln erecsiqrrn qkvveeapsi fldaetrram geqavalara vkyssagtve
      121 flvdskknfy flemntrlqv ehpvtecitg ldlvqemirv akgyplrhkq adiringwav
      181 ecrvyaedpy ksfglpsigr lsqyqeplhl pgvrvdsgiq pgsdisiyyd pmisklityg
      241 sdrtealkrm adaldnyvir gvthniallr eviinsrfvk gdistkflsd vypdgfkghm
      301 ltkseknqll aiasslfvaf qlraqhfqen srmpvikpdi anwelsvklh dkvhtvvasn
      361 ngsvfsvevd gsklnvtstw nlaspllsvs vdgtqrtvqe vlqvmcryns havgpvlshs
      421 cmarpvsfsr srwkhehsvs wysgargsgk vqhcqlstks vsvikypmvc gsgtemglfp
      481 kalsmatsvy fcilsciasv ayilvstvyg esllieieta imkpaiin
//
LOCUS       XP_047286333             366 aa            linear   PRI 05-AUG-2025
DEFINITION  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X18
            [Homo sapiens].
ACCESSION   XP_047286333
VERSION     XP_047286333.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430377.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..366
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..366
                     /product="propionyl-CoA carboxylase alpha chain,
                     mitochondrial isoform X18"
                     /calculated_mol_wt=40459
     Region          63..>358
                     /region_name="PccA"
                     /note="Acetyl/propionyl-CoA carboxylase, alpha subunit
                     [Lipid transport and metabolism]; COG4770"
                     /db_xref="CDD:443802"
     CDS             1..366
                     /gene="PCCA"
                     /coded_by="XM_047430377.1:29..1129"
                     /db_xref="GeneID:5095"
                     /db_xref="HGNC:HGNC:8653"
                     /db_xref="MIM:232000"
ORIGIN      
        1 magfwvgtap lvaagrrgrw ppqqlmlsaa lrtlkhvlyy srqclmvsrn lgsvgydpne
       61 ktfdkilvan rgeiacrvir tckkmgiktv aihsdvdass vhvkmadeav cvgpaptsks
      121 ylnmdaimea ikktraqavh pgygflsenk efarclaaed vvfigpdtha iqamgdkies
      181 kllakkaevn tipgfdgvvk daeeavriar eigypvmika saggggkgmr iawddeetrd
      241 gfrlssqeaa ssfgddrlli ekfidnprhi eiqvlgdkhg nalwlnerec siqrrnqkvv
      301 eeapsiflda etrramgeqa valaravkys sagtveflvd skknfyflem ntrlqvlhii
      361 lhyfer
//
LOCUS       XP_047286334             429 aa            linear   PRI 05-AUG-2025
DEFINITION  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X19
            [Homo sapiens].
ACCESSION   XP_047286334
VERSION     XP_047286334.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430378.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..429
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..429
                     /product="propionyl-CoA carboxylase alpha chain,
                     mitochondrial isoform X19"
                     /calculated_mol_wt=47437
     Region          <1..197
                     /region_name="PccA"
                     /note="Acetyl/propionyl-CoA carboxylase, alpha subunit
                     [Lipid transport and metabolism]; COG4770"
                     /db_xref="CDD:443802"
     Region          210..320
                     /region_name="PCC_BT"
                     /note="Propionyl-coenzyme A carboxylase BT domain;
                     pfam18140"
                     /db_xref="CDD:465666"
     CDS             1..429
                     /gene="PCCA"
                     /coded_by="XM_047430378.1:253..1542"
                     /db_xref="GeneID:5095"
                     /db_xref="HGNC:HGNC:8653"
                     /db_xref="MIM:232000"
ORIGIN      
        1 mgeqavalar avkyssagtv eflvdskknf yflemntrlq vehpvtecit gldlvqemir
       61 vakgyplrhk qadiringwa vecrvyaedp yksfglpsig rlsqyqeplh lpgvrvdsgi
      121 qpgsdisiyy dpmisklity gsdrtealkr madaldnyvi rgvthniall reviinsrfv
      181 kgdistkfls dvypdgfkgh mltkseknql laiasslfva fqlraqhfqe nsrmpvikpd
      241 ianwelsvkl hdkvhtvvas nngsvfsvev dgsklnvtst wnlaspllsv svdgtqrtvq
      301 evlqvmcryn shavgpvlsh scmarpvsfs rsrwkhehsv swysgargsg kvqhcqlstk
      361 svsvikypmv cgsgtemglf pkalsmatsv yfcilscias vayilvstvy gesllieiet
      421 aimkpaiin
//
LOCUS       XP_016876108            1237 aa            linear   PRI 05-AUG-2025
DEFINITION  protocadherin-9 isoform X1 [Homo sapiens].
ACCESSION   XP_016876108
VERSION     XP_016876108.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020619.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1237
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1237
                     /product="protocadherin-9 isoform X1"
                     /calculated_mol_wt=135934
     Region          29..138
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(36..37,93,95,134,136..137)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          146..248
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(153..154,211,213,244,246..247)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          258..354
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(263..264,319,321,350,352..353)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          370..465
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(375..376,428,430,461,463..464)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          473..568
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(480..481,531,533,564,566..567)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          576..671
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(583..584,634,636,667,669..670)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          687..776
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Region          777..1000
                     /region_name="Protocadherin"
                     /note="pfam08374"
                     /db_xref="CDD:462451"
     CDS             1..1237
                     /gene="PCDH9"
                     /coded_by="XM_017020619.3:464..4177"
                     /db_xref="GeneID:5101"
                     /db_xref="HGNC:HGNC:8661"
                     /db_xref="MIM:603581"
ORIGIN      
        1 mdlrdfylla aliaclrlds aiaqeliyti reelpenvpi gnipkdlnis hinaatgtsa
       61 slvyrlvska gdaplvkvss stgeifttsn ridreklcag asyaeenecf felevvilpn
      121 dffrlikiki ivkdtndnap mfpspvinis ipentlinsr fpipsatdpd tgfngvqhye
      181 llngqsvfgl divetpegek wpqlivqqnl dreqkdtyvm kikvedggtp qksstailqv
      241 tvsdvndnrp vfkegqvevh ipenapvgts viqlhatdad igsnaeiryi fgaqvapatk
      301 rlfalnnttg litvqrsldr eetaihkvtv lasdgsstpa ratvtinvtd vndnppnidl
      361 ryiispingt vylsekdpvn tkialitvsd kdtdvngkvi cfierevpfh lkavydnqyl
      421 letsslldye gtkefsfkiv asdsgkpsln qtalvrvkle dendnppifn qpvielsvse
      481 nnrrglyltt isatdedsgk nadivyqlgp nasffdldrk tgvltasrvf dreeqerfif
      541 tvtardngtp plqsqaaviv tvldendnsp kfthnhfqff vsenlpkyst vgvitvtdad
      601 agenkavtls ilndndnfvl dpysgviksn vsfdreqqss ytfdvkatdg gqpprsstak
      661 vtinvmdvnd nspvvispps ntsfklvpls aipgsvvaev favdvdtgmn aelkytivsg
      721 nnkglfridp vtgnitleek paptdvglhr lvvnisdlgy pkslhtlvlv flyvndtagn
      781 asyiydlirr tmetpldrni gdssqpyqne dyltimiaii agamvvivvi fvtvlvrcrh
      841 asrfkaaqrs kqgaewmspn qenkqnkkkk rkkrkspkss llnfvtiees kpddavhepi
      901 ngtislpael eeqsigrfdw gpappttfkp nspdlakhyk saspqpafhl kpdtpvsvkk
      961 hhviqelpld ntfvggcdtl skrsstssdh fsasecssqg gfktkgplht rqcnshsksd
     1021 nipvtpqkcp sstgfhiqen eeshyesqrr vtfhlpdgsq escsdsglgd hepvgsgtli
     1081 shplplvqpq defydqaspd krteadgnsd pnsdgplgpr glaeatemct qeclvlghsd
     1141 ncwmppglgp yqhpksplst fapqkewvkk dklvnghtlt rawkedsnrn qfndrkqygs
     1201 neghfnngsh mtdiplanlk sykqaggate spkehql
//
LOCUS       XP_016876109            1066 aa            linear   PRI 05-AUG-2025
DEFINITION  protocadherin-9 isoform X2 [Homo sapiens].
ACCESSION   XP_016876109
VERSION     XP_016876109.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020620.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1066
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1066
                     /product="protocadherin-9 isoform X2"
                     /calculated_mol_wt=117271
     Region          29..138
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(36..37,93,95,134,136..137)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          146..248
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(153..154,211,213,244,246..247)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          258..354
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(263..264,319,321,350,352..353)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          370..465
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(375..376,428,430,461,463..464)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          473..568
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(480..481,531,533,564,566..567)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          576..671
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(583..584,634,636,667,669..670)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          687..776
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Region          777..1000
                     /region_name="Protocadherin"
                     /note="pfam08374"
                     /db_xref="CDD:462451"
     CDS             1..1066
                     /gene="PCDH9"
                     /coded_by="XM_017020620.3:693..3893"
                     /db_xref="GeneID:5101"
                     /db_xref="HGNC:HGNC:8661"
                     /db_xref="MIM:603581"
ORIGIN      
        1 mdlrdfylla aliaclrlds aiaqeliyti reelpenvpi gnipkdlnis hinaatgtsa
       61 slvyrlvska gdaplvkvss stgeifttsn ridreklcag asyaeenecf felevvilpn
      121 dffrlikiki ivkdtndnap mfpspvinis ipentlinsr fpipsatdpd tgfngvqhye
      181 llngqsvfgl divetpegek wpqlivqqnl dreqkdtyvm kikvedggtp qksstailqv
      241 tvsdvndnrp vfkegqvevh ipenapvgts viqlhatdad igsnaeiryi fgaqvapatk
      301 rlfalnnttg litvqrsldr eetaihkvtv lasdgsstpa ratvtinvtd vndnppnidl
      361 ryiispingt vylsekdpvn tkialitvsd kdtdvngkvi cfierevpfh lkavydnqyl
      421 letsslldye gtkefsfkiv asdsgkpsln qtalvrvkle dendnppifn qpvielsvse
      481 nnrrglyltt isatdedsgk nadivyqlgp nasffdldrk tgvltasrvf dreeqerfif
      541 tvtardngtp plqsqaaviv tvldendnsp kfthnhfqff vsenlpkyst vgvitvtdad
      601 agenkavtls ilndndnfvl dpysgviksn vsfdreqqss ytfdvkatdg gqpprsstak
      661 vtinvmdvnd nspvvispps ntsfklvpls aipgsvvaev favdvdtgmn aelkytivsg
      721 nnkglfridp vtgnitleek paptdvglhr lvvnisdlgy pkslhtlvlv flyvndtagn
      781 asyiydlirr tmetpldrni gdssqpyqne dyltimiaii agamvvivvi fvtvlvrcrh
      841 asrfkaaqrs kqgaewmspn qenkqnkkkk rkkrkspkss llnfvtiees kpddavhepi
      901 ngtislpael eeqsigrfdw gpappttfkp nspdlakhyk saspqpafhl kpdtpvsvkk
      961 hhviqelpld ntfvggcdtl skrsstssdh fsasecssqg gfktkgplht rqcnshsksd
     1021 nipvtpqkcp sstgfhiqen eeshyeilqs kgvysyqhvt ikckqc
//
LOCUS       XP_011533401            1054 aa            linear   PRI 05-AUG-2025
DEFINITION  protocadherin-9 isoform X3 [Homo sapiens].
ACCESSION   XP_011533401
VERSION     XP_011533401.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535099.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1054
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1054
                     /product="protocadherin-9 isoform X3"
                     /calculated_mol_wt=115959
     Region          29..138
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(36..37,93,95,134,136..137)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          146..248
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(153..154,211,213,244,246..247)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          258..354
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(263..264,319,321,350,352..353)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          370..465
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(375..376,428,430,461,463..464)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          473..568
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(480..481,531,533,564,566..567)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          576..671
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(583..584,634,636,667,669..670)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          687..776
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Region          777..1000
                     /region_name="Protocadherin"
                     /note="pfam08374"
                     /db_xref="CDD:462451"
     CDS             1..1054
                     /gene="PCDH9"
                     /coded_by="XM_011535099.2:693..3857"
                     /db_xref="GeneID:5101"
                     /db_xref="HGNC:HGNC:8661"
                     /db_xref="MIM:603581"
ORIGIN      
        1 mdlrdfylla aliaclrlds aiaqeliyti reelpenvpi gnipkdlnis hinaatgtsa
       61 slvyrlvska gdaplvkvss stgeifttsn ridreklcag asyaeenecf felevvilpn
      121 dffrlikiki ivkdtndnap mfpspvinis ipentlinsr fpipsatdpd tgfngvqhye
      181 llngqsvfgl divetpegek wpqlivqqnl dreqkdtyvm kikvedggtp qksstailqv
      241 tvsdvndnrp vfkegqvevh ipenapvgts viqlhatdad igsnaeiryi fgaqvapatk
      301 rlfalnnttg litvqrsldr eetaihkvtv lasdgsstpa ratvtinvtd vndnppnidl
      361 ryiispingt vylsekdpvn tkialitvsd kdtdvngkvi cfierevpfh lkavydnqyl
      421 letsslldye gtkefsfkiv asdsgkpsln qtalvrvkle dendnppifn qpvielsvse
      481 nnrrglyltt isatdedsgk nadivyqlgp nasffdldrk tgvltasrvf dreeqerfif
      541 tvtardngtp plqsqaaviv tvldendnsp kfthnhfqff vsenlpkyst vgvitvtdad
      601 agenkavtls ilndndnfvl dpysgviksn vsfdreqqss ytfdvkatdg gqpprsstak
      661 vtinvmdvnd nspvvispps ntsfklvpls aipgsvvaev favdvdtgmn aelkytivsg
      721 nnkglfridp vtgnitleek paptdvglhr lvvnisdlgy pkslhtlvlv flyvndtagn
      781 asyiydlirr tmetpldrni gdssqpyqne dyltimiaii agamvvivvi fvtvlvrcrh
      841 asrfkaaqrs kqgaewmspn qenkqnkkkk rkkrkspkss llnfvtiees kpddavhepi
      901 ngtislpael eeqsigrfdw gpappttfkp nspdlakhyk saspqpafhl kpdtpvsvkk
      961 hhviqelpld ntfvggcdtl skrsstssdh fsasecssqg gfktkgplht rqgkqtlifp
     1021 sgaedfqchn vriifpnfpi lfvmsheyvs ekst
//
LOCUS       XP_005266465            1019 aa            linear   PRI 05-AUG-2025
DEFINITION  protocadherin-9 isoform X4 [Homo sapiens].
ACCESSION   XP_005266465
VERSION     XP_005266465.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266408.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1019
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1019
                     /product="protocadherin-9 isoform X4"
                     /calculated_mol_wt=111936
     Region          29..138
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(36..37,93,95,134,136..137)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          146..248
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(153..154,211,213,244,246..247)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          258..354
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(263..264,319,321,350,352..353)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          370..465
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(375..376,428,430,461,463..464)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          473..568
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(480..481,531,533,564,566..567)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          576..671
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(583..584,634,636,667,669..670)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          687..776
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Region          777..1000
                     /region_name="Protocadherin"
                     /note="pfam08374"
                     /db_xref="CDD:462451"
     CDS             1..1019
                     /gene="PCDH9"
                     /coded_by="XM_005266408.5:693..3752"
                     /db_xref="GeneID:5101"
                     /db_xref="HGNC:HGNC:8661"
                     /db_xref="MIM:603581"
ORIGIN      
        1 mdlrdfylla aliaclrlds aiaqeliyti reelpenvpi gnipkdlnis hinaatgtsa
       61 slvyrlvska gdaplvkvss stgeifttsn ridreklcag asyaeenecf felevvilpn
      121 dffrlikiki ivkdtndnap mfpspvinis ipentlinsr fpipsatdpd tgfngvqhye
      181 llngqsvfgl divetpegek wpqlivqqnl dreqkdtyvm kikvedggtp qksstailqv
      241 tvsdvndnrp vfkegqvevh ipenapvgts viqlhatdad igsnaeiryi fgaqvapatk
      301 rlfalnnttg litvqrsldr eetaihkvtv lasdgsstpa ratvtinvtd vndnppnidl
      361 ryiispingt vylsekdpvn tkialitvsd kdtdvngkvi cfierevpfh lkavydnqyl
      421 letsslldye gtkefsfkiv asdsgkpsln qtalvrvkle dendnppifn qpvielsvse
      481 nnrrglyltt isatdedsgk nadivyqlgp nasffdldrk tgvltasrvf dreeqerfif
      541 tvtardngtp plqsqaaviv tvldendnsp kfthnhfqff vsenlpkyst vgvitvtdad
      601 agenkavtls ilndndnfvl dpysgviksn vsfdreqqss ytfdvkatdg gqpprsstak
      661 vtinvmdvnd nspvvispps ntsfklvpls aipgsvvaev favdvdtgmn aelkytivsg
      721 nnkglfridp vtgnitleek paptdvglhr lvvnisdlgy pkslhtlvlv flyvndtagn
      781 asyiydlirr tmetpldrni gdssqpyqne dyltimiaii agamvvivvi fvtvlvrcrh
      841 asrfkaaqrs kqgaewmspn qenkqnkkkk rkkrkspkss llnfvtiees kpddavhepi
      901 ngtislpael eeqsigrfdw gpappttfkp nspdlakhyk saspqpafhl kpdtpvsvkk
      961 hhviqelpld ntfvggcdtl skrsstssdh fsasecssqg gfktkgplht rqfpsngkr
//
LOCUS       XP_016876110            1019 aa            linear   PRI 05-AUG-2025
DEFINITION  protocadherin-9 isoform X4 [Homo sapiens].
ACCESSION   XP_016876110
VERSION     XP_016876110.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020621.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1019
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1019
                     /product="protocadherin-9 isoform X4"
                     /calculated_mol_wt=111936
     Region          29..138
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(36..37,93,95,134,136..137)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          146..248
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(153..154,211,213,244,246..247)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          258..354
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(263..264,319,321,350,352..353)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          370..465
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(375..376,428,430,461,463..464)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          473..568
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(480..481,531,533,564,566..567)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          576..671
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(583..584,634,636,667,669..670)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          687..776
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Region          777..1000
                     /region_name="Protocadherin"
                     /note="pfam08374"
                     /db_xref="CDD:462451"
     CDS             1..1019
                     /gene="PCDH9"
                     /coded_by="XM_017020621.3:464..3523"
                     /db_xref="GeneID:5101"
                     /db_xref="HGNC:HGNC:8661"
                     /db_xref="MIM:603581"
ORIGIN      
        1 mdlrdfylla aliaclrlds aiaqeliyti reelpenvpi gnipkdlnis hinaatgtsa
       61 slvyrlvska gdaplvkvss stgeifttsn ridreklcag asyaeenecf felevvilpn
      121 dffrlikiki ivkdtndnap mfpspvinis ipentlinsr fpipsatdpd tgfngvqhye
      181 llngqsvfgl divetpegek wpqlivqqnl dreqkdtyvm kikvedggtp qksstailqv
      241 tvsdvndnrp vfkegqvevh ipenapvgts viqlhatdad igsnaeiryi fgaqvapatk
      301 rlfalnnttg litvqrsldr eetaihkvtv lasdgsstpa ratvtinvtd vndnppnidl
      361 ryiispingt vylsekdpvn tkialitvsd kdtdvngkvi cfierevpfh lkavydnqyl
      421 letsslldye gtkefsfkiv asdsgkpsln qtalvrvkle dendnppifn qpvielsvse
      481 nnrrglyltt isatdedsgk nadivyqlgp nasffdldrk tgvltasrvf dreeqerfif
      541 tvtardngtp plqsqaaviv tvldendnsp kfthnhfqff vsenlpkyst vgvitvtdad
      601 agenkavtls ilndndnfvl dpysgviksn vsfdreqqss ytfdvkatdg gqpprsstak
      661 vtinvmdvnd nspvvispps ntsfklvpls aipgsvvaev favdvdtgmn aelkytivsg
      721 nnkglfridp vtgnitleek paptdvglhr lvvnisdlgy pkslhtlvlv flyvndtagn
      781 asyiydlirr tmetpldrni gdssqpyqne dyltimiaii agamvvivvi fvtvlvrcrh
      841 asrfkaaqrs kqgaewmspn qenkqnkkkk rkkrkspkss llnfvtiees kpddavhepi
      901 ngtislpael eeqsigrfdw gpappttfkp nspdlakhyk saspqpafhl kpdtpvsvkk
      961 hhviqelpld ntfvggcdtl skrsstssdh fsasecssqg gfktkgplht rqfpsngkr
//
LOCUS       XP_047286337             122 aa            linear   PRI 05-AUG-2025
DEFINITION  Protein POLR1D isoform X2 [Homo sapiens].
ACCESSION   XP_047286337
VERSION     XP_047286337.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430381.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..122
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..122
                     /product="Protein POLR1D isoform X2"
                     /calculated_mol_wt=14201
     CDS             1..122
                     /gene="POLR1D"
                     /gene_synonym="AC19; POLR1C; RPA16; RPA9; RPAC2; RPC16;
                     RPO1-3; TCS2"
                     /coded_by="XM_047430381.1:1046..1414"
                     /db_xref="GeneID:51082"
                     /db_xref="HGNC:HGNC:20422"
                     /db_xref="MIM:613715"
ORIGIN      
        1 meedqelerk aieellkeak rgktraetmg pmgwmkcpla stnkrflint ikntlpshke
       61 qdheqkegdk epaksqaqke enpkkhrshp ykhsfrargs asyspprkrs sqdkyekrsn
      121 rr
//
LOCUS       XP_016876111             125 aa            linear   PRI 05-AUG-2025
DEFINITION  DNA-directed RNA polymerases I and III subunit RPAC2 isoform X1
            [Homo sapiens].
ACCESSION   XP_016876111
VERSION     XP_016876111.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020622.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..125
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..125
                     /product="DNA-directed RNA polymerases I and III subunit
                     RPAC2 isoform X1"
                     /calculated_mol_wt=14396
     CDS             1..125
                     /gene="POLR1D"
                     /gene_synonym="AC19; POLR1C; RPA16; RPA9; RPAC2; RPC16;
                     RPO1-3; TCS2"
                     /coded_by="XM_017020622.2:92..469"
                     /db_xref="GeneID:51082"
                     /db_xref="HGNC:HGNC:20422"
                     /db_xref="MIM:613715"
ORIGIN      
        1 mlpsqhqcvi ismeycqark licgsafkvf iavslnrmkc plastnkrfl intikntlps
       61 hkeqdheqke gdkepaksqa qkeenpkkhr shpykhsfra rgsasysppr krssqdkyek
      121 rsnrr
//
LOCUS       XP_005266473             217 aa            linear   PRI 05-AUG-2025
DEFINITION  lambda-crystallin homolog isoform X1 [Homo sapiens].
ACCESSION   XP_005266473
VERSION     XP_005266473.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266416.6
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..217
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..217
                     /product="lambda-crystallin homolog isoform X1"
                     /calculated_mol_wt=23592
     Region          9..>215
                     /region_name="PRK06129"
                     /note="3-hydroxyacyl-CoA dehydrogenase; Validated"
                     /db_xref="CDD:235706"
     CDS             1..217
                     /gene="CRYL1"
                     /gene_synonym="GDH; gul3DH; HEL30; lambda-CRY"
                     /coded_by="XM_005266416.6:64..717"
                     /db_xref="GeneID:51084"
                     /db_xref="HGNC:HGNC:18246"
                     /db_xref="MIM:609877"
ORIGIN      
        1 massaagcvv ivgsgvigrs wamlfasggf qvklydieqq qirnalenir kemklleqag
       61 slkgslsvee qlslisgcpn iqeavegamh iqecvpedle lkkkifaqld siiddrvils
      121 sstsclmpsk lfaglvhvkq civahpvnpp yyiplvelvp hpetapttvd rthalmkkig
      181 qcpmrvqkev agfvlnrlqy aiiseawrlv elasvlg
//
LOCUS       XP_005266476            1148 aa            linear   PRI 05-AUG-2025
DEFINITION  phospholipid-transporting ATPase IB isoform X1 [Homo sapiens].
ACCESSION   XP_005266476
VERSION     XP_005266476.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266419.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1148
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1148
                     /product="phospholipid-transporting ATPase IB isoform X1"
                     /calculated_mol_wt=129111
     Region          28..1066
                     /region_name="ATPase-Plipid"
                     /note="phospholipid-translocating P-type ATPase, flippase;
                     TIGR01652"
                     /db_xref="CDD:273734"
     Site            order(388..390,529,552..554,618,665..667,755,758,761,781,
                     784)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:319770"
     CDS             1..1148
                     /gene="ATP8A2"
                     /gene_synonym="ATP; ATPIB; CAMRQ4; IB; ML-1"
                     /coded_by="XM_005266419.2:112..3558"
                     /db_xref="GeneID:51761"
                     /db_xref="HGNC:HGNC:13533"
                     /db_xref="MIM:605870"
ORIGIN      
        1 msratsvgdq leapartiyl nqphlnkfrd nqistakysv ltflprflye qirraanaff
       61 lfiallqqip dvsptgrytt lvpliiilti agikeivedf krhkadnavn kkktivlrng
      121 mwhtimwkev avgdivkvvn gqylpadvvl lsssepqamc yvetanldge tnlkirqgls
      181 htadmqtrev lmklsgtiec egpnrhlydf tgnlnldgks lvalgpdqil lrgtqlrntq
      241 wvfgivvytg hdtklmqnst kaplkrsnve kvtnvqilvl fgillvmalv ssagalywnr
      301 shgeknwyik kmdttsdnfg ynlltfiily nnlipisllv tlevvkytqa lfinwdtdmy
      361 yigndtpama rtsnlneelg qvkylfsdkt gtltcnimnf kkcsiagvty ghfpelarep
      421 ssddfcrmpp pcsdscdfdd prllkniedr hptapciqef ltllavchtv vpekdgdnii
      481 yqasspdeaa lvkgakklgf vftartpfsv iieamgqeqt fgilnvlefs sdrkrmsviv
      541 rtpsgrlrly ckgadnvife rlskdskyme etlchleyfa teglrtlcva yadlseneye
      601 ewlkvyqeas tilkdraqrl eecyeiiekn llllgataie drlqagvpet iatllkaeik
      661 iwvltgdkqe tainigyscr lvsqnmalil lkedsldatr aaitqhctdl gnllgkendv
      721 aliidghtlk yalsfevrrs fldlalscka viccrvsplq kseivdvvkk rvkaitlaig
      781 dgandvgmiq tahvgvgisg negmqatnns dyaiaqfsyl eklllvhgaw synrvtkcil
      841 ycfyknvvly iielwfafvn gfsgqilfer wciglynvif talppftlgi fersctqesm
      901 lrfpqlykit qngegfntkv fwghcinalv hslilfwfpm kalehdtvlt sghatdylfv
      961 gnivytyvvv tvclkaglet tawtkfshla vwgsmltwlv ffgiystiwp tipiapdmrg
     1021 qatmvlssah fwlglflvpt acliedvawr aakhtckktl leevqeletk srvlgkavlr
     1081 dsngkrlner drlikrlgrk tpptlfrgss lqqgvphgya fsqeehgavs qeeviraydt
     1141 tkkksrkk
//
LOCUS       XP_011533406            1148 aa            linear   PRI 05-AUG-2025
DEFINITION  phospholipid-transporting ATPase IB isoform X2 [Homo sapiens].
ACCESSION   XP_011533406
VERSION     XP_011533406.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535104.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1148
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1148
                     /product="phospholipid-transporting ATPase IB isoform X2"
                     /calculated_mol_wt=129305
     Region          34..1066
                     /region_name="ATPase-Plipid"
                     /note="phospholipid-translocating P-type ATPase, flippase;
                     TIGR01652"
                     /db_xref="CDD:273734"
     Site            order(388..390,529,552..554,618,665..667,755,758,761,781,
                     784)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:319770"
     CDS             1..1148
                     /gene="ATP8A2"
                     /gene_synonym="ATP; ATPIB; CAMRQ4; IB; ML-1"
                     /coded_by="XM_011535104.3:95..3541"
                     /db_xref="GeneID:51761"
                     /db_xref="HGNC:HGNC:13533"
                     /db_xref="MIM:605870"
ORIGIN      
        1 mrtvitftpl dksfeescrr kywnwgsfgi vhsstakysv ltflprflye qirraanaff
       61 lfiallqqip dvsptgrytt lvpliiilti agikeivedf krhkadnavn kkktivlrng
      121 mwhtimwkev avgdivkvvn gqylpadvvl lsssepqamc yvetanldge tnlkirqgls
      181 htadmqtrev lmklsgtiec egpnrhlydf tgnlnldgks lvalgpdqil lrgtqlrntq
      241 wvfgivvytg hdtklmqnst kaplkrsnve kvtnvqilvl fgillvmalv ssagalywnr
      301 shgeknwyik kmdttsdnfg ynlltfiily nnlipisllv tlevvkytqa lfinwdtdmy
      361 yigndtpama rtsnlneelg qvkylfsdkt gtltcnimnf kkcsiagvty ghfpelarep
      421 ssddfcrmpp pcsdscdfdd prllkniedr hptapciqef ltllavchtv vpekdgdnii
      481 yqasspdeaa lvkgakklgf vftartpfsv iieamgqeqt fgilnvlefs sdrkrmsviv
      541 rtpsgrlrly ckgadnvife rlskdskyme etlchleyfa teglrtlcva yadlseneye
      601 ewlkvyqeas tilkdraqrl eecyeiiekn llllgataie drlqagvpet iatllkaeik
      661 iwvltgdkqe tainigyscr lvsqnmalil lkedsldatr aaitqhctdl gnllgkendv
      721 aliidghtlk yalsfevrrs fldlalscka viccrvsplq kseivdvvkk rvkaitlaig
      781 dgandvgmiq tahvgvgisg negmqatnns dyaiaqfsyl eklllvhgaw synrvtkcil
      841 ycfyknvvly iielwfafvn gfsgqilfer wciglynvif talppftlgi fersctqesm
      901 lrfpqlykit qngegfntkv fwghcinalv hslilfwfpm kalehdtvlt sghatdylfv
      961 gnivytyvvv tvclkaglet tawtkfshla vwgsmltwlv ffgiystiwp tipiapdmrg
     1021 qatmvlssah fwlglflvpt acliedvawr aakhtckktl leevqeletk srvlgkavlr
     1081 dsngkrlner drlikrlgrk tpptlfrgss lqqgvphgya fsqeehgavs qeeviraydt
     1141 tkkksrkk
//
LOCUS       XP_047286339            1148 aa            linear   PRI 05-AUG-2025
DEFINITION  phospholipid-transporting ATPase IB isoform X1 [Homo sapiens].
ACCESSION   XP_047286339
VERSION     XP_047286339.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430383.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1148
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1148
                     /product="phospholipid-transporting ATPase IB isoform X1"
                     /calculated_mol_wt=129111
     Region          28..1066
                     /region_name="ATPase-Plipid"
                     /note="phospholipid-translocating P-type ATPase, flippase;
                     TIGR01652"
                     /db_xref="CDD:273734"
     Site            order(388..390,529,552..554,618,665..667,755,758,761,781,
                     784)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:319770"
     CDS             1..1148
                     /gene="ATP8A2"
                     /gene_synonym="ATP; ATPIB; CAMRQ4; IB; ML-1"
                     /coded_by="XM_047430383.1:830..4276"
                     /db_xref="GeneID:51761"
                     /db_xref="HGNC:HGNC:13533"
                     /db_xref="MIM:605870"
ORIGIN      
        1 msratsvgdq leapartiyl nqphlnkfrd nqistakysv ltflprflye qirraanaff
       61 lfiallqqip dvsptgrytt lvpliiilti agikeivedf krhkadnavn kkktivlrng
      121 mwhtimwkev avgdivkvvn gqylpadvvl lsssepqamc yvetanldge tnlkirqgls
      181 htadmqtrev lmklsgtiec egpnrhlydf tgnlnldgks lvalgpdqil lrgtqlrntq
      241 wvfgivvytg hdtklmqnst kaplkrsnve kvtnvqilvl fgillvmalv ssagalywnr
      301 shgeknwyik kmdttsdnfg ynlltfiily nnlipisllv tlevvkytqa lfinwdtdmy
      361 yigndtpama rtsnlneelg qvkylfsdkt gtltcnimnf kkcsiagvty ghfpelarep
      421 ssddfcrmpp pcsdscdfdd prllkniedr hptapciqef ltllavchtv vpekdgdnii
      481 yqasspdeaa lvkgakklgf vftartpfsv iieamgqeqt fgilnvlefs sdrkrmsviv
      541 rtpsgrlrly ckgadnvife rlskdskyme etlchleyfa teglrtlcva yadlseneye
      601 ewlkvyqeas tilkdraqrl eecyeiiekn llllgataie drlqagvpet iatllkaeik
      661 iwvltgdkqe tainigyscr lvsqnmalil lkedsldatr aaitqhctdl gnllgkendv
      721 aliidghtlk yalsfevrrs fldlalscka viccrvsplq kseivdvvkk rvkaitlaig
      781 dgandvgmiq tahvgvgisg negmqatnns dyaiaqfsyl eklllvhgaw synrvtkcil
      841 ycfyknvvly iielwfafvn gfsgqilfer wciglynvif talppftlgi fersctqesm
      901 lrfpqlykit qngegfntkv fwghcinalv hslilfwfpm kalehdtvlt sghatdylfv
      961 gnivytyvvv tvclkaglet tawtkfshla vwgsmltwlv ffgiystiwp tipiapdmrg
     1021 qatmvlssah fwlglflvpt acliedvawr aakhtckktl leevqeletk srvlgkavlr
     1081 dsngkrlner drlikrlgrk tpptlfrgss lqqgvphgya fsqeehgavs qeeviraydt
     1141 tkkksrkk
//
LOCUS       XP_011533409            1063 aa            linear   PRI 05-AUG-2025
DEFINITION  phospholipid-transporting ATPase IB isoform X8 [Homo sapiens].
ACCESSION   XP_011533409
VERSION     XP_011533409.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535107.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1063
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1063
                     /product="phospholipid-transporting ATPase IB isoform X8"
                     /calculated_mol_wt=119365
     Region          68..1051
                     /region_name="ATPase-Plipid"
                     /note="phospholipid-translocating P-type ATPase, flippase;
                     TIGR01652"
                     /db_xref="CDD:273734"
     Site            order(428..430,569,592..594,658,705..707,795,798,801,821,
                     824)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:319770"
     CDS             1..1063
                     /gene="ATP8A2"
                     /gene_synonym="ATP; ATPIB; CAMRQ4; IB; ML-1"
                     /coded_by="XM_011535107.4:240..3431"
                     /db_xref="GeneID:51761"
                     /db_xref="HGNC:HGNC:13533"
                     /db_xref="MIM:605870"
ORIGIN      
        1 mlngagldka lkmslprrsr irssvgpvrs slgykkaede msratsvgdq leapartiyl
       61 nqphlnkfrd nqistakysv ltflprflye qirraanaff lfiallqqip dvsptgrytt
      121 lvpliiilti agikeivedf krhkadnavn kkktivlrng mwhtimwkev avgdivkvvn
      181 gqylpadvvl lsssepqamc yvetanldge tnlkirqgls htadmqtrev lmklsgtiec
      241 egpnrhlydf tgnlnldgks lvalgpdqil lrgtqlrntq wvfgivvytg hdtklmqnst
      301 kaplkrsnve kvtnvqilvl fgillvmalv ssagalywnr shgeknwyik kmdttsdnfg
      361 ynlltfiily nnlipisllv tlevvkytqa lfinwdtdmy yigndtpama rtsnlneelg
      421 qvkylfsdkt gtltcnimnf kkcsiagvty ghfpelarep ssddfcrmpp pcsdscdfdd
      481 prllkniedr hptapciqef ltllavchtv vpekdgdnii yqasspdeaa lvkgakklgf
      541 vftartpfsv iieamgqeqt fgilnvlefs sdrkrmsviv rtpsgrlrly ckgadnvife
      601 rlskdskyme etlchleyfa teglrtlcva yadlseneye ewlkvyqeas tilkdraqrl
      661 eecyeiiekn llllgataie drlqagvpet iatllkaeik iwvltgdkqe tainigyscr
      721 lvsqnmalil lkedsldatr aaitqhctdl gnllgkendv aliidghtlk yalsfevrrs
      781 fldlalscka viccrvsplq kseivdvvkk rvkaitlaig dgandvgmiq tahvgvgisg
      841 negmqatnns dyaiaqfsyl eklllvhgaw synrvtkcil ycfyknvvly iielwfafvn
      901 gfsgqilfer wciglynvif talppftlgi fersctqesm lrfpqlykit qngegfntkv
      961 fwghcinalv hslilfwfpm kalehdtvlt sghatdylfv gnivytyvvv tvclkaglet
     1021 tawtkfshla vwgsmltwlv ffgiystiwp tipiapdmrg qpr
//
LOCUS       XP_011533411            1028 aa            linear   PRI 05-AUG-2025
DEFINITION  phospholipid-transporting ATPase IB isoform X3 [Homo sapiens].
ACCESSION   XP_011533411
VERSION     XP_011533411.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535109.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1028
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1028
                     /product="phospholipid-transporting ATPase IB isoform X3"
                     /calculated_mol_wt=115471
     Region          1..946
                     /region_name="ATPase-Plipid"
                     /note="phospholipid-translocating P-type ATPase, flippase;
                     TIGR01652"
                     /db_xref="CDD:273734"
     Site            order(268..270,409,432..434,498,545..547,635,638,641,661,
                     664)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:319770"
     CDS             1..1028
                     /gene="ATP8A2"
                     /gene_synonym="ATP; ATPIB; CAMRQ4; IB; ML-1"
                     /coded_by="XM_011535109.4:2258..5344"
                     /db_xref="GeneID:51761"
                     /db_xref="HGNC:HGNC:13533"
                     /db_xref="MIM:605870"
ORIGIN      
        1 mwhtimwkev avgdivkvvn gqylpadvvl lsssepqamc yvetanldge tnlkirqgls
       61 htadmqtrev lmklsgtiec egpnrhlydf tgnlnldgks lvalgpdqil lrgtqlrntq
      121 wvfgivvytg hdtklmqnst kaplkrsnve kvtnvqilvl fgillvmalv ssagalywnr
      181 shgeknwyik kmdttsdnfg ynlltfiily nnlipisllv tlevvkytqa lfinwdtdmy
      241 yigndtpama rtsnlneelg qvkylfsdkt gtltcnimnf kkcsiagvty ghfpelarep
      301 ssddfcrmpp pcsdscdfdd prllkniedr hptapciqef ltllavchtv vpekdgdnii
      361 yqasspdeaa lvkgakklgf vftartpfsv iieamgqeqt fgilnvlefs sdrkrmsviv
      421 rtpsgrlrly ckgadnvife rlskdskyme etlchleyfa teglrtlcva yadlseneye
      481 ewlkvyqeas tilkdraqrl eecyeiiekn llllgataie drlqagvpet iatllkaeik
      541 iwvltgdkqe tainigyscr lvsqnmalil lkedsldatr aaitqhctdl gnllgkendv
      601 aliidghtlk yalsfevrrs fldlalscka viccrvsplq kseivdvvkk rvkaitlaig
      661 dgandvgmiq tahvgvgisg negmqatnns dyaiaqfsyl eklllvhgaw synrvtkcil
      721 ycfyknvvly iielwfafvn gfsgqilfer wciglynvif talppftlgi fersctqesm
      781 lrfpqlykit qngegfntkv fwghcinalv hslilfwfpm kalehdtvlt sghatdylfv
      841 gnivytyvvv tvclkaglet tawtkfshla vwgsmltwlv ffgiystiwp tipiapdmrg
      901 qatmvlssah fwlglflvpt acliedvawr aakhtckktl leevqeletk srvlgkavlr
      961 dsngkrlner drlikrlgrk tpptlfrgss lqqgvphgya fsqeehgavs qeeviraydt
     1021 tkkksrkk
//
LOCUS       XP_024305137             990 aa            linear   PRI 05-AUG-2025
DEFINITION  phospholipid-transporting ATPase IB isoform X4 [Homo sapiens].
ACCESSION   XP_024305137
VERSION     XP_024305137.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449369.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..990
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..990
                     /product="phospholipid-transporting ATPase IB isoform X4"
                     /calculated_mol_wt=111277
     Region          1..908
                     /region_name="ATPase-Plipid"
                     /note="phospholipid-translocating P-type ATPase, flippase;
                     TIGR01652"
                     /db_xref="CDD:273734"
     Site            order(230..232,371,394..396,460,507..509,597,600,603,623,
                     626)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:319770"
     CDS             1..990
                     /gene="ATP8A2"
                     /gene_synonym="ATP; ATPIB; CAMRQ4; IB; ML-1"
                     /coded_by="XM_024449369.1:234..3206"
                     /db_xref="GeneID:51761"
                     /db_xref="HGNC:HGNC:13533"
                     /db_xref="MIM:605870"
ORIGIN      
        1 mcyvetanld getnlkirqg lshtadmqtr evlmklsgti ecegpnrhly dftgnlnldg
       61 kslvalgpdq illrgtqlrn tqwvfgivvy tghdtklmqn stkaplkrsn vekvtnvqil
      121 vlfgillvma lvssagalyw nrshgeknwy ikkmdttsdn fgynlltfii lynnlipisl
      181 lvtlevvkyt qalfinwdtd myyigndtpa martsnlnee lgqvkylfsd ktgtltcnim
      241 nfkkcsiagv tyghfpelar epssddfcrm pppcsdscdf ddprllknie drhptapciq
      301 efltllavch tvvpekdgdn iiyqasspde aalvkgakkl gfvftartpf sviieamgqe
      361 qtfgilnvle fssdrkrmsv ivrtpsgrlr lyckgadnvi ferlskdsky meetlchley
      421 fateglrtlc vayadlsene yeewlkvyqe astilkdraq rleecyeiie knllllgata
      481 iedrlqagvp etiatllkae ikiwvltgdk qetainigys crlvsqnmal illkedslda
      541 traaitqhct dlgnllgken dvaliidght lkyalsfevr rsfldlalsc kaviccrvsp
      601 lqkseivdvv kkrvkaitla igdgandvgm iqtahvgvgi sgnegmqatn nsdyaiaqfs
      661 yleklllvhg awsynrvtkc ilycfyknvv lyiielwfaf vngfsgqilf erwciglynv
      721 iftalppftl gifersctqe smlrfpqlyk itqngegfnt kvfwghcina lvhslilfwf
      781 pmkalehdtv ltsghatdyl fvgnivytyv vvtvclkagl ettawtkfsh lavwgsmltw
      841 lvffgiysti wptipiapdm rgqatmvlss ahfwlglflv ptacliedva wraakhtckk
      901 tlleevqele tksrvlgkav lrdsngkrln erdrlikrlg rktpptlfrg sslqqgvphg
      961 yafsqeehga vsqeeviray dttkkksrkk
//
LOCUS       XP_011533415             803 aa            linear   PRI 05-AUG-2025
DEFINITION  phospholipid-transporting ATPase IB isoform X5 [Homo sapiens].
ACCESSION   XP_011533415
VERSION     XP_011533415.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535113.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..803
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..803
                     /product="phospholipid-transporting ATPase IB isoform X5"
                     /calculated_mol_wt=90165
     Region          68..>801
                     /region_name="Haloacid Dehalogenase-like Hydrolases"
                     /note="The haloacid dehalogenase (HAD) superfamily
                     includes carbon and phosphorus hydrolases such as
                     2-haloalkonoate dehalogenase, epoxide hydrolase,
                     phosphoserine phosphatase, phosphomannomutase,
                     phosphoglycolate phosphatase, P-type ATPase, among others.
                     These...; cl21460"
                     /db_xref="CDD:473868"
     CDS             1..803
                     /gene="ATP8A2"
                     /gene_synonym="ATP; ATPIB; CAMRQ4; IB; ML-1"
                     /coded_by="XM_011535113.3:240..2651"
                     /db_xref="GeneID:51761"
                     /db_xref="HGNC:HGNC:13533"
                     /db_xref="MIM:605870"
ORIGIN      
        1 mlngagldka lkmslprrsr irssvgpvrs slgykkaede msratsvgdq leapartiyl
       61 nqphlnkfrd nqistakysv ltflprflye qirraanaff lfiallqqip dvsptgrytt
      121 lvpliiilti agikeivedf krhkadnavn kkktivlrng mwhtimwkev avgdivkvvn
      181 gqylpadvvl lsssepqamc yvetanldge tnlkirqgls htadmqtrev lmklsgtiec
      241 egpnrhlydf tgnlnldgks lvalgpdqil lrgtqlrntq wvfgivvytg hdtklmqnst
      301 kaplkrsnve kvtnvqilvl fgillvmalv ssagalywnr shgeknwyik kmdttsdnfg
      361 ynlltfiily nnlipisllv tlevvkytqa lfinwdtdmy yigndtpama rtsnlneelg
      421 qvkylfsdkt gtltcnimnf kkcsiagvty ghfpelarep ssddfcrmpp pcsdscdfdd
      481 prllkniedr hptapciqef ltllavchtv vpekdgdnii yqasspdeaa lvkgakklgf
      541 vftartpfsv iieamgqeqt fgilnvlefs sdrkrmsviv rtpsgrlrly ckgadnvife
      601 rlskdskyme etlchleyfa teglrtlcva yadlseneye ewlkvyqeas tilkdraqrl
      661 eecyeiiekn llllgataie drlqagvpet iatllkaeik iwvltgdkqe tainigyscr
      721 lvsqnmalil lkedsldatr aaitqhctdl gnllgkendv aliidghtlk yalsfevrrs
      781 fldlalscka viccrslfls kwr
//
LOCUS       XP_016876114             751 aa            linear   PRI 05-AUG-2025
DEFINITION  phospholipid-transporting ATPase IB isoform X6 [Homo sapiens].
ACCESSION   XP_016876114
VERSION     XP_016876114.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020625.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..751
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..751
                     /product="phospholipid-transporting ATPase IB isoform X6"
                     /calculated_mol_wt=84563
     Region          68..>738
                     /region_name="Haloacid Dehalogenase-like Hydrolases"
                     /note="The haloacid dehalogenase (HAD) superfamily
                     includes carbon and phosphorus hydrolases such as
                     2-haloalkonoate dehalogenase, epoxide hydrolase,
                     phosphoserine phosphatase, phosphomannomutase,
                     phosphoglycolate phosphatase, P-type ATPase, among others.
                     These...; cl21460"
                     /db_xref="CDD:473868"
     CDS             1..751
                     /gene="ATP8A2"
                     /gene_synonym="ATP; ATPIB; CAMRQ4; IB; ML-1"
                     /coded_by="XM_017020625.3:240..2495"
                     /db_xref="GeneID:51761"
                     /db_xref="HGNC:HGNC:13533"
                     /db_xref="MIM:605870"
ORIGIN      
        1 mlngagldka lkmslprrsr irssvgpvrs slgykkaede msratsvgdq leapartiyl
       61 nqphlnkfrd nqistakysv ltflprflye qirraanaff lfiallqqip dvsptgrytt
      121 lvpliiilti agikeivedf krhkadnavn kkktivlrng mwhtimwkev avgdivkvvn
      181 gqylpadvvl lsssepqamc yvetanldge tnlkirqgls htadmqtrev lmklsgtiec
      241 egpnrhlydf tgnlnldgks lvalgpdqil lrgtqlrntq wvfgivvytg hdtklmqnst
      301 kaplkrsnve kvtnvqilvl fgillvmalv ssagalywnr shgeknwyik kmdttsdnfg
      361 ynlltfiily nnlipisllv tlevvkytqa lfinwdtdmy yigndtpama rtsnlneelg
      421 qvkylfsdkt gtltcnimnf kkcsiagvty ghfpelarep ssddfcrmpp pcsdscdfdd
      481 prllkniedr hptapciqef ltllavchtv vpekdgdnii yqasspdeaa lvkgakklgf
      541 vftartpfsv iieamgqeqt fgilnvlefs sdrkrmsviv rtpsgrlrly ckgadnvife
      601 rlskdskyme etlchleyfa teglrtlcva yadlseneye ewlkvyqeas tilkdraqrl
      661 eecyeiiekn llllgataie drlqagvpet iatllkaeik iwvltgdkqe tainigyscr
      721 lvsqnmalil lkedsldrww vksrgqdsfi t
//
LOCUS       XP_016876115             739 aa            linear   PRI 05-AUG-2025
DEFINITION  phospholipid-transporting ATPase IB isoform X7 [Homo sapiens].
ACCESSION   XP_016876115
VERSION     XP_016876115.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020626.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..739
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..739
                     /product="phospholipid-transporting ATPase IB isoform X7"
                     /calculated_mol_wt=83011
     Region          68..>737
                     /region_name="Haloacid Dehalogenase-like Hydrolases"
                     /note="The haloacid dehalogenase (HAD) superfamily
                     includes carbon and phosphorus hydrolases such as
                     2-haloalkonoate dehalogenase, epoxide hydrolase,
                     phosphoserine phosphatase, phosphomannomutase,
                     phosphoglycolate phosphatase, P-type ATPase, among others.
                     These...; cl21460"
                     /db_xref="CDD:473868"
     CDS             1..739
                     /gene="ATP8A2"
                     /gene_synonym="ATP; ATPIB; CAMRQ4; IB; ML-1"
                     /coded_by="XM_017020626.2:240..2459"
                     /db_xref="GeneID:51761"
                     /db_xref="HGNC:HGNC:13533"
                     /db_xref="MIM:605870"
ORIGIN      
        1 mlngagldka lkmslprrsr irssvgpvrs slgykkaede msratsvgdq leapartiyl
       61 nqphlnkfrd nqistakysv ltflprflye qirraanaff lfiallqqip dvsptgrytt
      121 lvpliiilti agikeivedf krhkadnavn kkktivlrng mwhtimwkev avgdivkvvn
      181 gqylpadvvl lsssepqamc yvetanldge tnlkirqgls htadmqtrev lmklsgtiec
      241 egpnrhlydf tgnlnldgks lvalgpdqil lrgtqlrntq wvfgivvytg hdtklmqnst
      301 kaplkrsnve kvtnvqilvl fgillvmalv ssagalywnr shgeknwyik kmdttsdnfg
      361 ynlltfiily nnlipisllv tlevvkytqa lfinwdtdmy yigndtpama rtsnlneelg
      421 qvkylfsdkt gtltcnimnf kkcsiagvty ghfpelarep ssddfcrmpp pcsdscdfdd
      481 prllkniedr hptapciqef ltllavchtv vpekdgdnii yqasspdeaa lvkgakklgf
      541 vftartpfsv iieamgqeqt fgilnvlefs sdrkrmsviv rtpsgrlrly ckgadnvife
      601 rlskdskyme etlchleyfa teglrtlcva yadlseneye ewlkvyqeas tilkdraqrl
      661 eecyeiiekn llllgataie drlqagvpet iatllkaeik iwvltgdkqe tainigyscr
      721 lvsqnmalil lkedsldvp
//
LOCUS       XP_047286350             109 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin-like protein 3 isoform X1 [Homo sapiens].
ACCESSION   XP_047286350
VERSION     XP_047286350.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430394.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..109
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..109
                     /product="ubiquitin-like protein 3 isoform X1"
                     /calculated_mol_wt=12224
     Region          2..83
                     /region_name="Ubl_UBL3"
                     /note="ubiquitin-like (Ubl) domain found in ubiquitin-like
                     protein 3 (UBL3) and similar proteins; cd17048"
                     /db_xref="CDD:340568"
     CDS             1..109
                     /gene="UBL3"
                     /gene_synonym="HCG-1; PNSC1"
                     /coded_by="XM_047430394.1:521..850"
                     /db_xref="GeneID:5412"
                     /db_xref="HGNC:HGNC:12504"
                     /db_xref="MIM:604711"
ORIGIN      
        1 minlrlilvs gktkeflfsp ndsasdiakh vydnwpmdwe eeqvsspnil rliyqgrflh
       61 gnvtlgalkl pfgkttvmhl varetlpepn sqgqrnrekt gesnccvil
//
LOCUS       XP_047286351             879 aa            linear   PRI 05-AUG-2025
DEFINITION  M-phase phosphoprotein 8 isoform X1 [Homo sapiens].
ACCESSION   XP_047286351
VERSION     XP_047286351.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430395.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..879
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..879
                     /product="M-phase phosphoprotein 8 isoform X1"
                     /calculated_mol_wt=98874
     Region          58..108
                     /region_name="CD_MMP8"
                     /note="chromodomain of M-phase phosphoprotein 8; cd18633"
                     /db_xref="CDD:349283"
     Site            order(58..61,80,83,89,91,95..96,98..102)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:349283"
     Region          <200..>550
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          485..746
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Site            order(600,602,606..607,610..612,614..615,619,622,631,633,
                     635,639..640,643..645,647..648,652,655,664,666,668,
                     672..673,676..678,680..681,685,688)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          600..631
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          633..664
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          666..695
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     CDS             1..879
                     /gene="MPHOSPH8"
                     /gene_synonym="HSMPP8; mpp8; TWA3"
                     /coded_by="XM_047430395.1:91..2730"
                     /db_xref="GeneID:54737"
                     /db_xref="HGNC:HGNC:29810"
                     /db_xref="MIM:611626"
ORIGIN      
        1 meqvaegarv tavpvsaads teelaeveeg vgvvgednda aargaeafgd seedgedvfe
       61 vekildmkte ggkvlykvrw kgytsdddtw epeihledck evllefrkki aenkakavrk
      121 diqrlslnnd ifeansdsdq qsetkedtsp kkkkkklrqr eekspddlkk kkakagklkd
      181 kskpdlessl eslvfdlrtk kriseakeel keskkpkkde vketkelkkv kkgeirdlkt
      241 ktredpkenr ktkkekfves qvesessvln dspfpeddse glhsdsreek qntksarera
      301 gqdmglehgf ekpldsamsa eedtdvrgrr kkktprkaed trenrklenk naflekktvp
      361 kkqrnqdrsk saaeleklmp vsaqtpkgrr lsgeerglws tdsaeedket krneskekyq
      421 krhdsdkeek grkepkglkt lkeirnafdl fkltpeeknd vsennrkree ipldfktidd
      481 hktkenkqsl kerrntrdet dtwayiaaeg dqevldsvcq adensdgrqq ilslgmdlql
      541 ewmkledfqk hldgkdenfa atdaipsnvl rdavkngdyi tvkvalnsne eynldqedss
      601 gmtlvmlaaa ggqddllrll itkgakvngr qkngttalih aaeknflttv ailleagafv
      661 nvqqsngeta lmkackrgns divrlviecg adcnilskhq nsalhfakqs nnvlvydllk
      721 nhletlsrva eetikdyfea rlallepvfp iachrlcegp dfstdfnykp pqnipegsgi
      781 llfifhanfl gkeviarlcg pcsvqavvln dkfqlpvflt gsrsvvqagv qwrglqltgv
      841 ltsqaqailp pqppnylglk mtvilfthsa llqvpinss
//
LOCUS       XP_047286352             867 aa            linear   PRI 05-AUG-2025
DEFINITION  M-phase phosphoprotein 8 isoform X2 [Homo sapiens].
ACCESSION   XP_047286352
VERSION     XP_047286352.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430396.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..867
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..867
                     /product="M-phase phosphoprotein 8 isoform X2"
                     /calculated_mol_wt=97506
     Region          58..108
                     /region_name="CD_MMP8"
                     /note="chromodomain of M-phase phosphoprotein 8; cd18633"
                     /db_xref="CDD:349283"
     Site            order(58..61,80,83,89,91,95..96,98..102)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:349283"
     Region          <200..>550
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          485..746
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Site            order(600,602,606..607,610..612,614..615,619,622,631,633,
                     635,639..640,643..645,647..648,652,655,664,666,668,
                     672..673,676..678,680..681,685,688)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          600..631
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          633..664
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          666..695
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     CDS             1..867
                     /gene="MPHOSPH8"
                     /gene_synonym="HSMPP8; mpp8; TWA3"
                     /coded_by="XM_047430396.1:91..2694"
                     /db_xref="GeneID:54737"
                     /db_xref="HGNC:HGNC:29810"
                     /db_xref="MIM:611626"
ORIGIN      
        1 meqvaegarv tavpvsaads teelaeveeg vgvvgednda aargaeafgd seedgedvfe
       61 vekildmkte ggkvlykvrw kgytsdddtw epeihledck evllefrkki aenkakavrk
      121 diqrlslnnd ifeansdsdq qsetkedtsp kkkkkklrqr eekspddlkk kkakagklkd
      181 kskpdlessl eslvfdlrtk kriseakeel keskkpkkde vketkelkkv kkgeirdlkt
      241 ktredpkenr ktkkekfves qvesessvln dspfpeddse glhsdsreek qntksarera
      301 gqdmglehgf ekpldsamsa eedtdvrgrr kkktprkaed trenrklenk naflekktvp
      361 kkqrnqdrsk saaeleklmp vsaqtpkgrr lsgeerglws tdsaeedket krneskekyq
      421 krhdsdkeek grkepkglkt lkeirnafdl fkltpeeknd vsennrkree ipldfktidd
      481 hktkenkqsl kerrntrdet dtwayiaaeg dqevldsvcq adensdgrqq ilslgmdlql
      541 ewmkledfqk hldgkdenfa atdaipsnvl rdavkngdyi tvkvalnsne eynldqedss
      601 gmtlvmlaaa ggqddllrll itkgakvngr qkngttalih aaeknflttv ailleagafv
      661 nvqqsngeta lmkackrgns divrlviecg adcnilskhq nsalhfakqs nnvlvydllk
      721 nhletlsrva eetikdyfea rlallepvfp iachrlcegp dfstdfnykp pqnipegsgi
      781 llfifhanfl gkeviarlcg pcsvqavvln dkfqlpvflt gsrsvvqagv qwrglqltgv
      841 ltsqaqailp pqppnylglk mhattsg
//
LOCUS       XP_047286353             597 aa            linear   PRI 05-AUG-2025
DEFINITION  M-phase phosphoprotein 8 isoform X3 [Homo sapiens].
ACCESSION   XP_047286353
VERSION     XP_047286353.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430397.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..597
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..597
                     /product="M-phase phosphoprotein 8 isoform X3"
                     /calculated_mol_wt=68328
     Region          58..108
                     /region_name="CD_MMP8"
                     /note="chromodomain of M-phase phosphoprotein 8; cd18633"
                     /db_xref="CDD:349283"
     Site            order(58..61,80,83,89,91,95..96,98..102)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:349283"
     Region          <161..>513
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     CDS             1..597
                     /gene="MPHOSPH8"
                     /gene_synonym="HSMPP8; mpp8; TWA3"
                     /coded_by="XM_047430397.1:91..1884"
                     /db_xref="GeneID:54737"
                     /db_xref="HGNC:HGNC:29810"
                     /db_xref="MIM:611626"
ORIGIN      
        1 meqvaegarv tavpvsaads teelaeveeg vgvvgednda aargaeafgd seedgedvfe
       61 vekildmkte ggkvlykvrw kgytsdddtw epeihledck evllefrkki aenkakavrk
      121 diqrlslnnd ifeansdsdq qsetkedtsp kkkkkklrqr eekspddlkk kkakagklkd
      181 kskpdlessl eslvfdlrtk kriseakeel keskkpkkde vketkelkkv kkgeirdlkt
      241 ktredpkenr ktkkekfves qvesessvln dspfpeddse glhsdsreek qntksarera
      301 gqdmglehgf ekpldsamsa eedtdvrgrr kkktprkaed trenrklenk naflekktvp
      361 kkqrnqdrsk saaeleklmp vsaqtpkgrr lsgeerglws tdsaeedket krneskekyq
      421 krhdsdkeek grkepkglkt lkeirnafdl fkltpeeknd vsennrkree ipldfktidd
      481 hktkenkqsl kerrntrdet dtwayiaaeg dqevldsvcq adensdgrqq ilslgmdlql
      541 ewmkledfqk hldgkdenfa atdaipsnvl rdavkngdyi tvkvalnsne eynldqe
//
LOCUS       XP_047286354             713 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane and coiled-coil domain-containing protein 3 isoform
            X1 [Homo sapiens].
ACCESSION   XP_047286354
VERSION     XP_047286354.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430398.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..713
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..713
                     /product="transmembrane and coiled-coil domain-containing
                     protein 3 isoform X1"
                     /calculated_mol_wt=79401
     Region          303..>681
                     /region_name="RosB"
                     /note="Predicted Kef-type K+ transport protein, K+/H+
                     antiporter domain [Inorganic ion transport and
                     metabolism]; COG4651"
                     /db_xref="CDD:443689"
     CDS             1..713
                     /gene="SLC9D1"
                     /gene_synonym="C13orf11; TMCO3"
                     /coded_by="XM_047430398.1:3414..5555"
                     /db_xref="GeneID:55002"
                     /db_xref="HGNC:HGNC:20329"
                     /db_xref="MIM:617134"
ORIGIN      
        1 mitkssrdla envcltckls gaetrgllcp alrtwimkvl grsffwvlfp vlpwavqave
       61 heevaqrvik lhrgrgvaam qsrqwvrdsc rklsgllrqk navlnklkta igavekdvgl
      121 sdeeklfqvh tfeifqkeln esensvfqav yglqralqgd ykdvvnmkes srqrlealre
      181 aaikeeteym ellaaekhqv ealknmqhqn qslsmldeil edvrkaadrl eeeieehafd
      241 dnksvkgvnf eavlrveeee anskqnitkr eveddlglsm lidsqnnqyi ltkprdstip
      301 radhhfikdi vtigmlslpc gwlctaiglp tmfgyiicgv llgpsglnsi ksivqvetlg
      361 efgvfftlfl vglefspekl rkvwkislqg pcymtllmia fgllwghllr ikptqsvfis
      421 tclslsstpl vsrflmgsar gdkegdidys tvllgmlvtq dvqlglfmav mptliqagas
      481 asssivvevl rilvligqil fslaavfllc lvikkyligp yyrklhmesk gnkeililgi
      541 safiflmltv telldvsmel gcflagalvs sqgpvvteei atsiepirdf laivffasig
      601 lhvfptfvay eltvlvfltl svvvmkflla alvlslilpr ssqyikwivs aglaqvsefs
      661 fvlgsrarra gvisrevyll ilsvttlsll lapvlwraai trcvprperr ssl
//
LOCUS       XP_047286355             691 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane and coiled-coil domain-containing protein 3 isoform
            X2 [Homo sapiens].
ACCESSION   XP_047286355
VERSION     XP_047286355.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430399.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..691
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..691
                     /product="transmembrane and coiled-coil domain-containing
                     protein 3 isoform X2"
                     /calculated_mol_wt=76280
     Region          303..>599
                     /region_name="RosB"
                     /note="Predicted Kef-type K+ transport protein, K+/H+
                     antiporter domain [Inorganic ion transport and
                     metabolism]; COG4651"
                     /db_xref="CDD:443689"
     CDS             1..691
                     /gene="SLC9D1"
                     /gene_synonym="C13orf11; TMCO3"
                     /coded_by="XM_047430399.1:990..3065"
                     /db_xref="GeneID:55002"
                     /db_xref="HGNC:HGNC:20329"
                     /db_xref="MIM:617134"
ORIGIN      
        1 mitkssrdla envcltckls gaetrgllcp alrtwimkvl grsffwvlfp vlpwavqave
       61 heevaqrvik lhrgrgvaam qsrqwvrdsc rklsgllrqk navlnklkta igavekdvgl
      121 sdeeklfqvh tfeifqkeln esensvfqav yglqralqgd ykdvvnmkes srqrlealre
      181 aaikeeteym ellaaekhqv ealknmqhqn qslsmldeil edvrkaadrl eeeieehafd
      241 dnksvkgvnf eavlrveeee anskqnitkr eveddlglsm lidsqnnqyi ltkprdstip
      301 radhhfikdi vtigmlslpc gwlctaiglp tmfgyiicgv llgpsglnsi ksivqvetlg
      361 efgvfftlfl vglefspekl rkvwkislqg pcymtllmia fgllwghllr ikptqsvfis
      421 tclslsstpl vsrflmgsar gdkegdidys tvllgmlvtq dvqlglfmav mptliqagas
      481 asssivvevl rilvligqil fslaavfllc lvikkyligp yyrklhmesk gnkeililgi
      541 safiflmltv telldvsmel gcflagalvs sqgpvvteei atsiepirdf laivffasiv
      601 spggagpvsh saeeqpvhqv drlcgacpgq rvflcpgepg aksgrhlsgg vppytecdha
      661 qplarpgave scnhevcaqt getvqplmar r
//
LOCUS       XP_006720032             677 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane and coiled-coil domain-containing protein 3 isoform
            X3 [Homo sapiens].
ACCESSION   XP_006720032
VERSION     XP_006720032.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006719969.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..677
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..677
                     /product="transmembrane and coiled-coil domain-containing
                     protein 3 isoform X3"
                     /calculated_mol_wt=75467
     Region          267..>645
                     /region_name="RosB"
                     /note="Predicted Kef-type K+ transport protein, K+/H+
                     antiporter domain [Inorganic ion transport and
                     metabolism]; COG4651"
                     /db_xref="CDD:443689"
     CDS             1..677
                     /gene="SLC9D1"
                     /gene_synonym="C13orf11; TMCO3"
                     /coded_by="XM_006719969.2:120..2153"
                     /db_xref="GeneID:55002"
                     /db_xref="HGNC:HGNC:20329"
                     /db_xref="MIM:617134"
ORIGIN      
        1 mkvlgrsffw vlfpvlpwav qaveheevaq rviklhrgrg vaamqsrqwv rdscrklsgl
       61 lrqknavlnk lktaigavek dvglsdeekl fqvhtfeifq kelnesensv fqavyglqra
      121 lqgdykdvvn mkessrqrle alreaaikee teymellaae khqvealknm qhqnqslsml
      181 deiledvrka adrleeeiee hafddnksvk gvnfeavlrv eeeeanskqn itkreveddl
      241 glsmlidsqn nqyiltkprd stipradhhf ikdivtigml slpcgwlcta iglptmfgyi
      301 icgvllgpsg lnsiksivqv etlgefgvff tlflvglefs peklrkvwki slqgpcymtl
      361 lmiafgllwg hllrikptqs vfistclsls stplvsrflm gsargdkegd idystvllgm
      421 lvtqdvqlgl fmavmptliq agasasssiv vevlrilvli gqilfslaav fllclvikky
      481 ligpyyrklh meskgnkeil ilgisafifl mltvtelldv smelgcflag alvssqgpvv
      541 teeiatsiep irdflaivff asiglhvfpt fvayeltvlv fltlsvvvmk fllaalvlsl
      601 ilprssqyik wivsaglaqv sefsfvlgsr arragvisre vyllilsvtt lslllapvlw
      661 raaitrcvpr perrssl
//
LOCUS       XP_011535800             677 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane and coiled-coil domain-containing protein 3 isoform
            X3 [Homo sapiens].
ACCESSION   XP_011535800
VERSION     XP_011535800.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537498.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..677
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..677
                     /product="transmembrane and coiled-coil domain-containing
                     protein 3 isoform X3"
                     /calculated_mol_wt=75467
     Region          267..>645
                     /region_name="RosB"
                     /note="Predicted Kef-type K+ transport protein, K+/H+
                     antiporter domain [Inorganic ion transport and
                     metabolism]; COG4651"
                     /db_xref="CDD:443689"
     CDS             1..677
                     /gene="SLC9D1"
                     /gene_synonym="C13orf11; TMCO3"
                     /coded_by="XM_011537498.3:238..2271"
                     /db_xref="GeneID:55002"
                     /db_xref="HGNC:HGNC:20329"
                     /db_xref="MIM:617134"
ORIGIN      
        1 mkvlgrsffw vlfpvlpwav qaveheevaq rviklhrgrg vaamqsrqwv rdscrklsgl
       61 lrqknavlnk lktaigavek dvglsdeekl fqvhtfeifq kelnesensv fqavyglqra
      121 lqgdykdvvn mkessrqrle alreaaikee teymellaae khqvealknm qhqnqslsml
      181 deiledvrka adrleeeiee hafddnksvk gvnfeavlrv eeeeanskqn itkreveddl
      241 glsmlidsqn nqyiltkprd stipradhhf ikdivtigml slpcgwlcta iglptmfgyi
      301 icgvllgpsg lnsiksivqv etlgefgvff tlflvglefs peklrkvwki slqgpcymtl
      361 lmiafgllwg hllrikptqs vfistclsls stplvsrflm gsargdkegd idystvllgm
      421 lvtqdvqlgl fmavmptliq agasasssiv vevlrilvli gqilfslaav fllclvikky
      481 ligpyyrklh meskgnkeil ilgisafifl mltvtelldv smelgcflag alvssqgpvv
      541 teeiatsiep irdflaivff asiglhvfpt fvayeltvlv fltlsvvvmk fllaalvlsl
      601 ilprssqyik wivsaglaqv sefsfvlgsr arragvisre vyllilsvtt lslllapvlw
      661 raaitrcvpr perrssl
//
LOCUS       XP_047286356             655 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane and coiled-coil domain-containing protein 3 isoform
            X4 [Homo sapiens].
ACCESSION   XP_047286356
VERSION     XP_047286356.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430400.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..655
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..655
                     /product="transmembrane and coiled-coil domain-containing
                     protein 3 isoform X4"
                     /calculated_mol_wt=72346
     Region          267..>563
                     /region_name="RosB"
                     /note="Predicted Kef-type K+ transport protein, K+/H+
                     antiporter domain [Inorganic ion transport and
                     metabolism]; COG4651"
                     /db_xref="CDD:443689"
     CDS             1..655
                     /gene="SLC9D1"
                     /gene_synonym="C13orf11; TMCO3"
                     /coded_by="XM_047430400.1:241..2208"
                     /db_xref="GeneID:55002"
                     /db_xref="HGNC:HGNC:20329"
                     /db_xref="MIM:617134"
ORIGIN      
        1 mkvlgrsffw vlfpvlpwav qaveheevaq rviklhrgrg vaamqsrqwv rdscrklsgl
       61 lrqknavlnk lktaigavek dvglsdeekl fqvhtfeifq kelnesensv fqavyglqra
      121 lqgdykdvvn mkessrqrle alreaaikee teymellaae khqvealknm qhqnqslsml
      181 deiledvrka adrleeeiee hafddnksvk gvnfeavlrv eeeeanskqn itkreveddl
      241 glsmlidsqn nqyiltkprd stipradhhf ikdivtigml slpcgwlcta iglptmfgyi
      301 icgvllgpsg lnsiksivqv etlgefgvff tlflvglefs peklrkvwki slqgpcymtl
      361 lmiafgllwg hllrikptqs vfistclsls stplvsrflm gsargdkegd idystvllgm
      421 lvtqdvqlgl fmavmptliq agasasssiv vevlrilvli gqilfslaav fllclvikky
      481 ligpyyrklh meskgnkeil ilgisafifl mltvtelldv smelgcflag alvssqgpvv
      541 teeiatsiep irdflaivff asivspggag pvshsaeeqp vhqvdrlcga cpgqrvflcp
      601 gepgaksgrh lsggvppyte cdhaqplarp gavescnhev caqtgetvqp lmarr
//
LOCUS       XP_047286357             655 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane and coiled-coil domain-containing protein 3 isoform
            X4 [Homo sapiens].
ACCESSION   XP_047286357
VERSION     XP_047286357.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430401.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..655
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..655
                     /product="transmembrane and coiled-coil domain-containing
                     protein 3 isoform X4"
                     /calculated_mol_wt=72346
     Region          267..>563
                     /region_name="RosB"
                     /note="Predicted Kef-type K+ transport protein, K+/H+
                     antiporter domain [Inorganic ion transport and
                     metabolism]; COG4651"
                     /db_xref="CDD:443689"
     CDS             1..655
                     /gene="SLC9D1"
                     /gene_synonym="C13orf11; TMCO3"
                     /coded_by="XM_047430401.1:120..2087"
                     /db_xref="GeneID:55002"
                     /db_xref="HGNC:HGNC:20329"
                     /db_xref="MIM:617134"
ORIGIN      
        1 mkvlgrsffw vlfpvlpwav qaveheevaq rviklhrgrg vaamqsrqwv rdscrklsgl
       61 lrqknavlnk lktaigavek dvglsdeekl fqvhtfeifq kelnesensv fqavyglqra
      121 lqgdykdvvn mkessrqrle alreaaikee teymellaae khqvealknm qhqnqslsml
      181 deiledvrka adrleeeiee hafddnksvk gvnfeavlrv eeeeanskqn itkreveddl
      241 glsmlidsqn nqyiltkprd stipradhhf ikdivtigml slpcgwlcta iglptmfgyi
      301 icgvllgpsg lnsiksivqv etlgefgvff tlflvglefs peklrkvwki slqgpcymtl
      361 lmiafgllwg hllrikptqs vfistclsls stplvsrflm gsargdkegd idystvllgm
      421 lvtqdvqlgl fmavmptliq agasasssiv vevlrilvli gqilfslaav fllclvikky
      481 ligpyyrklh meskgnkeil ilgisafifl mltvtelldv smelgcflag alvssqgpvv
      541 teeiatsiep irdflaivff asivspggag pvshsaeeqp vhqvdrlcga cpgqrvflcp
      601 gepgaksgrh lsggvppyte cdhaqplarp gavescnhev caqtgetvqp lmarr
//
LOCUS       XP_047286358             649 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane and coiled-coil domain-containing protein 3 isoform
            X5 [Homo sapiens].
ACCESSION   XP_047286358
VERSION     XP_047286358.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430402.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..649
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..649
                     /product="transmembrane and coiled-coil domain-containing
                     protein 3 isoform X5"
                     /calculated_mol_wt=72037
     Region          244..>617
                     /region_name="RosB"
                     /note="Predicted Kef-type K+ transport protein, K+/H+
                     antiporter domain [Inorganic ion transport and
                     metabolism]; COG4651"
                     /db_xref="CDD:443689"
     CDS             1..649
                     /gene="SLC9D1"
                     /gene_synonym="C13orf11; TMCO3"
                     /coded_by="XM_047430402.1:990..2939"
                     /db_xref="GeneID:55002"
                     /db_xref="HGNC:HGNC:20329"
                     /db_xref="MIM:617134"
ORIGIN      
        1 mitkssrdla envcltckls gaetrgllcp alrtwimkvl grsffwvlfp vlpwavqave
       61 heevaqrvik lhrgrgvaam qsrqwvrdsc rklsgllrqk navlnklkta igavekdvgl
      121 sdeeklfqvh tfeifqkeln esensvfqav yglqralqgd ykdvvnmkes srqrlealre
      181 aaikeeteym ellaaekhqv ealknmqhqn qslsmldeil edvrkaadrl eeeieehafd
      241 dnksdivtig mlslpcgwlc taiglptmfg yiicgvllgp sglnsiksiv qvetlgefgv
      301 fftlflvgle fspeklrkvw kislqgpcym tllmiafgll wghllrikpt qsvfistcls
      361 lsstplvsrf lmgsargdke gdidystvll gmlvtqdvql glfmavmptl iqagasasss
      421 ivvevlrilv ligqilfsla avfllclvik kyligpyyrk lhmeskgnke ililgisafi
      481 flmltvtell dvsmelgcfl agalvssqgp vvteeiatsi epirdflaiv ffasiglhvf
      541 ptfvayeltv lvfltlsvvv mkfllaalvl slilprssqy ikwivsagla qvsefsfvlg
      601 srarragvis revyllilsv ttlslllapv lwraaitrcv prperrssl
//
LOCUS       XP_047286359             627 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane and coiled-coil domain-containing protein 3 isoform
            X6 [Homo sapiens].
ACCESSION   XP_047286359
VERSION     XP_047286359.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430403.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..627
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..627
                     /product="transmembrane and coiled-coil domain-containing
                     protein 3 isoform X6"
                     /calculated_mol_wt=68917
     Region          <86..237
                     /region_name="YhaN"
                     /note="Uncharacterized conserved protein YhaN, contains
                     AAA domain [Function unknown]; COG4717"
                     /db_xref="CDD:443752"
     Region          <169..249
                     /region_name="ATP-synt_Fo_b"
                     /note="F-type ATP synthase, membrane subunit b; cl21478"
                     /db_xref="CDD:473877"
     Region          244..>535
                     /region_name="RosB"
                     /note="Predicted Kef-type K+ transport protein, K+/H+
                     antiporter domain [Inorganic ion transport and
                     metabolism]; COG4651"
                     /db_xref="CDD:443689"
     CDS             1..627
                     /gene="SLC9D1"
                     /gene_synonym="C13orf11; TMCO3"
                     /coded_by="XM_047430403.1:990..2873"
                     /db_xref="GeneID:55002"
                     /db_xref="HGNC:HGNC:20329"
                     /db_xref="MIM:617134"
ORIGIN      
        1 mitkssrdla envcltckls gaetrgllcp alrtwimkvl grsffwvlfp vlpwavqave
       61 heevaqrvik lhrgrgvaam qsrqwvrdsc rklsgllrqk navlnklkta igavekdvgl
      121 sdeeklfqvh tfeifqkeln esensvfqav yglqralqgd ykdvvnmkes srqrlealre
      181 aaikeeteym ellaaekhqv ealknmqhqn qslsmldeil edvrkaadrl eeeieehafd
      241 dnksdivtig mlslpcgwlc taiglptmfg yiicgvllgp sglnsiksiv qvetlgefgv
      301 fftlflvgle fspeklrkvw kislqgpcym tllmiafgll wghllrikpt qsvfistcls
      361 lsstplvsrf lmgsargdke gdidystvll gmlvtqdvql glfmavmptl iqagasasss
      421 ivvevlrilv ligqilfsla avfllclvik kyligpyyrk lhmeskgnke ililgisafi
      481 flmltvtell dvsmelgcfl agalvssqgp vvteeiatsi epirdflaiv ffasivspgg
      541 agpvshsaee qpvhqvdrlc gacpgqrvfl cpgepgaksg rhlsggvppy tecdhaqpla
      601 rpgavescnh evcaqtgetv qplmarr
//
LOCUS       XP_047286360             616 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane and coiled-coil domain-containing protein 3 isoform
            X7 [Homo sapiens].
ACCESSION   XP_047286360
VERSION     XP_047286360.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430404.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..616
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..616
                     /product="transmembrane and coiled-coil domain-containing
                     protein 3 isoform X7"
                     /calculated_mol_wt=68116
     Region          <86..237
                     /region_name="YhaN"
                     /note="Uncharacterized conserved protein YhaN, contains
                     AAA domain [Function unknown]; COG4717"
                     /db_xref="CDD:443752"
     Region          304..>383
                     /region_name="KefB"
                     /note="Kef-type K+ transport system, membrane component
                     KefB [Inorganic ion transport and metabolism]; COG0475"
                     /db_xref="CDD:440243"
     CDS             1..616
                     /gene="SLC9D1"
                     /gene_synonym="C13orf11; TMCO3"
                     /coded_by="XM_047430404.1:990..2840"
                     /db_xref="GeneID:55002"
                     /db_xref="HGNC:HGNC:20329"
                     /db_xref="MIM:617134"
ORIGIN      
        1 mitkssrdla envcltckls gaetrgllcp alrtwimkvl grsffwvlfp vlpwavqave
       61 heevaqrvik lhrgrgvaam qsrqwvrdsc rklsgllrqk navlnklkta igavekdvgl
      121 sdeeklfqvh tfeifqkeln esensvfqav yglqralqgd ykdvvnmkes srqrlealre
      181 aaikeeteym ellaaekhqv ealknmqhqn qslsmldeil edvrkaadrl eeeieehafd
      241 dnksvkgvnf eavlrveeee anskqnitkr eveddlglsm lidsqnnqyi ltkprdstip
      301 radhhfikdi vtigmlslpc gwlctaiglp tmfgyiicgv llgpsglnsi ksivqvetlg
      361 efgvfftlfl vglefspekl rkhcrgsspn pgfdwsdsff tsggfsfmsc ykevshwtll
      421 seaahgkqge qrnpdlgnic lyllnvnghg aagrlhgagl fpgwsarlls gprghrgdrh
      481 lhrthprlpg hrflrlhrap rvphvcgvra hgagvphlvs ggdevspgga gpvshsaeeq
      541 pvhqvdrlcg acpgqrvflc pgepgaksgr hlsggvppyt ecdhaqplar pgavescnhe
      601 vcaqtgetvq plmarr
//
LOCUS       XP_047286361             595 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane and coiled-coil domain-containing protein 3 isoform
            X8 [Homo sapiens].
ACCESSION   XP_047286361
VERSION     XP_047286361.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430405.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..595
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..595
                     /product="transmembrane and coiled-coil domain-containing
                     protein 3 isoform X8"
                     /calculated_mol_wt=66335
     Region          310..>489
                     /region_name="Na_H_Exchanger"
                     /note="Sodium/hydrogen exchanger family; pfam00999"
                     /db_xref="CDD:425982"
     CDS             1..595
                     /gene="SLC9D1"
                     /gene_synonym="C13orf11; TMCO3"
                     /coded_by="XM_047430405.1:990..2777"
                     /db_xref="GeneID:55002"
                     /db_xref="HGNC:HGNC:20329"
                     /db_xref="MIM:617134"
ORIGIN      
        1 mitkssrdla envcltckls gaetrgllcp alrtwimkvl grsffwvlfp vlpwavqave
       61 heevaqrvik lhrgrgvaam qsrqwvrdsc rklsgllrqk navlnklkta igavekdvgl
      121 sdeeklfqvh tfeifqkeln esensvfqav yglqralqgd ykdvvnmkes srqrlealre
      181 aaikeeteym ellaaekhqv ealknmqhqn qslsmldeil edvrkaadrl eeeieehafd
      241 dnksvkgvnf eavlrveeee anskqnitkr eveddlglsm lidsqnnqyi ltkprdstip
      301 radhhfikdi vtigmlslpc gwlctaiglp tmfgyiicgv llgpsglnsi ksivqvetlg
      361 efgvfftlfl vglefspekl rkvwkislqg pcymtllmia fgllwghllr ikptqsvfis
      421 tclslsstpl vsrflmgsar gdkegdidys tvllgmlvtq dvqlglfmav mptliqagas
      481 assrsdvlmg slskhaetvr tavdtaprmc rsraahawtc rwhgalyiqi kssmrvdlqv
      541 trrpvradqe qhtrgpaggt aprtcrsraa hacgpaggta prtcrsraar vwtcr
//
LOCUS       XP_047286362             579 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane and coiled-coil domain-containing protein 3 isoform
            X9 [Homo sapiens].
ACCESSION   XP_047286362
VERSION     XP_047286362.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430406.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..579
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..579
                     /product="transmembrane and coiled-coil domain-containing
                     protein 3 isoform X9"
                     /calculated_mol_wt=64996
     Region          304..>547
                     /region_name="KefB"
                     /note="Kef-type K+ transport system, membrane component
                     KefB [Inorganic ion transport and metabolism]; COG0475"
                     /db_xref="CDD:440243"
     CDS             1..579
                     /gene="SLC9D1"
                     /gene_synonym="C13orf11; TMCO3"
                     /coded_by="XM_047430406.1:990..2729"
                     /db_xref="GeneID:55002"
                     /db_xref="HGNC:HGNC:20329"
                     /db_xref="MIM:617134"
ORIGIN      
        1 mitkssrdla envcltckls gaetrgllcp alrtwimkvl grsffwvlfp vlpwavqave
       61 heevaqrvik lhrgrgvaam qsrqwvrdsc rklsgllrqk navlnklkta igavekdvgl
      121 sdeeklfqvh tfeifqkeln esensvfqav yglqralqgd ykdvvnmkes srqrlealre
      181 aaikeeteym ellaaekhqv ealknmqhqn qslsmldeil edvrkaadrl eeeieehafd
      241 dnksvkgvnf eavlrveeee anskqnitkr eveddlglsm lidsqnnqyi ltkprdstip
      301 radhhfikdi vtigmlslpc gwlctaiglp tmfgyiicgv llgpsglnsi ksivqvetlg
      361 efgvfftlfl vglefspekl rkvwkislqg pcymtllmia fgllwghllr ikptqsvfis
      421 tclslsstpl vsrflmgsar gdkegdidys tvllgmlvtq dvqlglfmav mptliqagas
      481 asssivvevl rilvligqil fslaavfllc lvikkyligp yyrklhmesk gnkeililgi
      541 safiflmlts iflfennsqq ncliwttsvl psqwllplq
//
LOCUS       XP_047286363             553 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane and coiled-coil domain-containing protein 3 isoform
            X10 [Homo sapiens].
ACCESSION   XP_047286363
VERSION     XP_047286363.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430407.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..553
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..553
                     /product="transmembrane and coiled-coil domain-containing
                     protein 3 isoform X10"
                     /calculated_mol_wt=61958
     Region          <86..288
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          180..>237
                     /region_name="Com_YlbF"
                     /note="Control of competence regulator ComK, YlbF/YmcA;
                     cl42071"
                     /db_xref="CDD:455416"
     Region          304..>383
                     /region_name="KefB"
                     /note="Kef-type K+ transport system, membrane component
                     KefB [Inorganic ion transport and metabolism]; COG0475"
                     /db_xref="CDD:440243"
     CDS             1..553
                     /gene="SLC9D1"
                     /gene_synonym="C13orf11; TMCO3"
                     /coded_by="XM_047430407.1:990..2651"
                     /db_xref="GeneID:55002"
                     /db_xref="HGNC:HGNC:20329"
                     /db_xref="MIM:617134"
ORIGIN      
        1 mitkssrdla envcltckls gaetrgllcp alrtwimkvl grsffwvlfp vlpwavqave
       61 heevaqrvik lhrgrgvaam qsrqwvrdsc rklsgllrqk navlnklkta igavekdvgl
      121 sdeeklfqvh tfeifqkeln esensvfqav yglqralqgd ykdvvnmkes srqrlealre
      181 aaikeeteym ellaaekhqv ealknmqhqn qslsmldeil edvrkaadrl eeeieehafd
      241 dnksvkgvnf eavlrveeee anskqnitkr eveddlglsm lidsqnnqyi ltkprdstip
      301 radhhfikdi vtigmlslpc gwlctaiglp tmfgyiicgv llgpsglnsi ksivqvetlg
      361 efgvfftlfl vglefspekl rkhcrgsspn pgfdwsdsff tsggfsfmsc ykevshwtll
      421 seaahgkqge qrnpdlgnic lyllnvnghg aagrlhgagl fpgwsarlls gprghrgdrh
      481 lhrthprlpg hrflrlhsfs wrrwsclsfc rgaastssgs slrglprsas fplswgagre
      541 erasslgrct sly
//
LOCUS       XP_047286364             552 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane and coiled-coil domain-containing protein 3 isoform
            X11 [Homo sapiens].
ACCESSION   XP_047286364
VERSION     XP_047286364.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430408.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..552
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..552
                     /product="transmembrane and coiled-coil domain-containing
                     protein 3 isoform X11"
                     /calculated_mol_wt=60753
     Region          <86..237
                     /region_name="YhaN"
                     /note="Uncharacterized conserved protein YhaN, contains
                     AAA domain [Function unknown]; COG4717"
                     /db_xref="CDD:443752"
     Region          <169..249
                     /region_name="ATP-synt_Fo_b"
                     /note="F-type ATP synthase, membrane subunit b; cl21478"
                     /db_xref="CDD:473877"
     Region          245..>319
                     /region_name="KefB"
                     /note="Kef-type K+ transport system, membrane component
                     KefB [Inorganic ion transport and metabolism]; COG0475"
                     /db_xref="CDD:440243"
     CDS             1..552
                     /gene="SLC9D1"
                     /gene_synonym="C13orf11; TMCO3"
                     /coded_by="XM_047430408.1:990..2648"
                     /db_xref="GeneID:55002"
                     /db_xref="HGNC:HGNC:20329"
                     /db_xref="MIM:617134"
ORIGIN      
        1 mitkssrdla envcltckls gaetrgllcp alrtwimkvl grsffwvlfp vlpwavqave
       61 heevaqrvik lhrgrgvaam qsrqwvrdsc rklsgllrqk navlnklkta igavekdvgl
      121 sdeeklfqvh tfeifqkeln esensvfqav yglqralqgd ykdvvnmkes srqrlealre
      181 aaikeeteym ellaaekhqv ealknmqhqn qslsmldeil edvrkaadrl eeeieehafd
      241 dnksdivtig mlslpcgwlc taiglptmfg yiicgvllgp sglnsiksiv qvetlgefgv
      301 fftlflvgle fspeklrkhc rgsspnpgfd wsdsfftsgg fsfmscykev shwtllseaa
      361 hgkqgeqrnp dlgniclyll nvnghgaagr lhgaglfpgw sarllsgprg hrgdrhlhrt
      421 hprlpghrfl rlhraprvph vcgvrahgag vphlvsggde vspggagpvs hsaeeqpvhq
      481 vdrlcgacpg qrvflcpgep gaksgrhlsg gvppytecdh aqplarpgav escnhevcaq
      541 tgetvqplma rr
//
LOCUS       XP_047286365             533 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane and coiled-coil domain-containing protein 3 isoform
            X12 [Homo sapiens].
ACCESSION   XP_047286365
VERSION     XP_047286365.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430409.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..533
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..533
                     /product="transmembrane and coiled-coil domain-containing
                     protein 3 isoform X12"
                     /calculated_mol_wt=59694
     Region          304..>478
                     /region_name="KefB"
                     /note="Kef-type K+ transport system, membrane component
                     KefB [Inorganic ion transport and metabolism]; COG0475"
                     /db_xref="CDD:440243"
     CDS             1..533
                     /gene="SLC9D1"
                     /gene_synonym="C13orf11; TMCO3"
                     /coded_by="XM_047430409.1:990..2591"
                     /db_xref="GeneID:55002"
                     /db_xref="HGNC:HGNC:20329"
                     /db_xref="MIM:617134"
ORIGIN      
        1 mitkssrdla envcltckls gaetrgllcp alrtwimkvl grsffwvlfp vlpwavqave
       61 heevaqrvik lhrgrgvaam qsrqwvrdsc rklsgllrqk navlnklkta igavekdvgl
      121 sdeeklfqvh tfeifqkeln esensvfqav yglqralqgd ykdvvnmkes srqrlealre
      181 aaikeeteym ellaaekhqv ealknmqhqn qslsmldeil edvrkaadrl eeeieehafd
      241 dnksvkgvnf eavlrveeee anskqnitkr eveddlglsm lidsqnnqyi ltkprdstip
      301 radhhfikdi vtigmlslpc gwlctaiglp tmfgyiicgv llgpsglnsi ksivqvetlg
      361 efgvfftlfl vglefspekl rkvwkislqg pcymtllmia fgllwghllr ikptqsvfis
      421 tclslsstpl vsrflmgsar gdkegdidys tvllgmlvtq dvqlglfmav mptliqagas
      481 assrsrscwt spwswavswl erssplrapw sprrspppsn psatswpsfs spp
//
LOCUS       XP_047286366             533 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane and coiled-coil domain-containing protein 3 isoform
            X12 [Homo sapiens].
ACCESSION   XP_047286366
VERSION     XP_047286366.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430410.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..533
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..533
                     /product="transmembrane and coiled-coil domain-containing
                     protein 3 isoform X12"
                     /calculated_mol_wt=59694
     Region          304..>478
                     /region_name="KefB"
                     /note="Kef-type K+ transport system, membrane component
                     KefB [Inorganic ion transport and metabolism]; COG0475"
                     /db_xref="CDD:440243"
     CDS             1..533
                     /gene="SLC9D1"
                     /gene_synonym="C13orf11; TMCO3"
                     /coded_by="XM_047430410.1:990..2591"
                     /db_xref="GeneID:55002"
                     /db_xref="HGNC:HGNC:20329"
                     /db_xref="MIM:617134"
ORIGIN      
        1 mitkssrdla envcltckls gaetrgllcp alrtwimkvl grsffwvlfp vlpwavqave
       61 heevaqrvik lhrgrgvaam qsrqwvrdsc rklsgllrqk navlnklkta igavekdvgl
      121 sdeeklfqvh tfeifqkeln esensvfqav yglqralqgd ykdvvnmkes srqrlealre
      181 aaikeeteym ellaaekhqv ealknmqhqn qslsmldeil edvrkaadrl eeeieehafd
      241 dnksvkgvnf eavlrveeee anskqnitkr eveddlglsm lidsqnnqyi ltkprdstip
      301 radhhfikdi vtigmlslpc gwlctaiglp tmfgyiicgv llgpsglnsi ksivqvetlg
      361 efgvfftlfl vglefspekl rkvwkislqg pcymtllmia fgllwghllr ikptqsvfis
      421 tclslsstpl vsrflmgsar gdkegdidys tvllgmlvtq dvqlglfmav mptliqagas
      481 assrsrscwt spwswavswl erssplrapw sprrspppsn psatswpsfs spp
//
LOCUS       XP_047286367             493 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane and coiled-coil domain-containing protein 3 isoform
            X13 [Homo sapiens].
ACCESSION   XP_047286367
VERSION     XP_047286367.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430411.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..493
                     /product="transmembrane and coiled-coil domain-containing
                     protein 3 isoform X13"
                     /calculated_mol_wt=55310
     Region          304..>483
                     /region_name="KefB"
                     /note="Kef-type K+ transport system, membrane component
                     KefB [Inorganic ion transport and metabolism]; COG0475"
                     /db_xref="CDD:440243"
     CDS             1..493
                     /gene="SLC9D1"
                     /gene_synonym="C13orf11; TMCO3"
                     /coded_by="XM_047430411.1:990..2471"
                     /db_xref="GeneID:55002"
                     /db_xref="HGNC:HGNC:20329"
                     /db_xref="MIM:617134"
ORIGIN      
        1 mitkssrdla envcltckls gaetrgllcp alrtwimkvl grsffwvlfp vlpwavqave
       61 heevaqrvik lhrgrgvaam qsrqwvrdsc rklsgllrqk navlnklkta igavekdvgl
      121 sdeeklfqvh tfeifqkeln esensvfqav yglqralqgd ykdvvnmkes srqrlealre
      181 aaikeeteym ellaaekhqv ealknmqhqn qslsmldeil edvrkaadrl eeeieehafd
      241 dnksvkgvnf eavlrveeee anskqnitkr eveddlglsm lidsqnnqyi ltkprdstip
      301 radhhfikdi vtigmlslpc gwlctaiglp tmfgyiicgv llgpsglnsi ksivqvetlg
      361 efgvfftlfl vglefspekl rkvwkislqg pcymtllmia fgllwghllr ikptqsvfis
      421 tclslsstpl vsrflmgsar gdkegdidys tvllgmlvtq dvqlglfmav mptliqagas
      481 assreclwpf eaf
//
LOCUS       XP_047286368             464 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane and coiled-coil domain-containing protein 3 isoform
            X14 [Homo sapiens].
ACCESSION   XP_047286368
VERSION     XP_047286368.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430412.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..464
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..464
                     /product="transmembrane and coiled-coil domain-containing
                     protein 3 isoform X14"
                     /calculated_mol_wt=52262
     Region          304..>436
                     /region_name="KefB"
                     /note="Kef-type K+ transport system, membrane component
                     KefB [Inorganic ion transport and metabolism]; COG0475"
                     /db_xref="CDD:440243"
     CDS             1..464
                     /gene="SLC9D1"
                     /gene_synonym="C13orf11; TMCO3"
                     /coded_by="XM_047430412.1:990..2384"
                     /db_xref="GeneID:55002"
                     /db_xref="HGNC:HGNC:20329"
                     /db_xref="MIM:617134"
ORIGIN      
        1 mitkssrdla envcltckls gaetrgllcp alrtwimkvl grsffwvlfp vlpwavqave
       61 heevaqrvik lhrgrgvaam qsrqwvrdsc rklsgllrqk navlnklkta igavekdvgl
      121 sdeeklfqvh tfeifqkeln esensvfqav yglqralqgd ykdvvnmkes srqrlealre
      181 aaikeeteym ellaaekhqv ealknmqhqn qslsmldeil edvrkaadrl eeeieehafd
      241 dnksvkgvnf eavlrveeee anskqnitkr eveddlglsm lidsqnnqyi ltkprdstip
      301 radhhfikdi vtigmlslpc gwlctaiglp tmfgyiicgv llgpsglnsi ksivqvetlg
      361 efgvfftlfl vglefspekl rkvwkislqg pcymtllmia fgllwghllr ikptqsvfis
      421 tclslsstpl vsrflmgsar gdkegslnsf fpiwtpalcl rdah
//
LOCUS       XP_047286369             452 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane and coiled-coil domain-containing protein 3 isoform
            X15 [Homo sapiens].
ACCESSION   XP_047286369
VERSION     XP_047286369.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430413.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..452
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..452
                     /product="transmembrane and coiled-coil domain-containing
                     protein 3 isoform X15"
                     /calculated_mol_wt=50971
     Region          304..>436
                     /region_name="KefB"
                     /note="Kef-type K+ transport system, membrane component
                     KefB [Inorganic ion transport and metabolism]; COG0475"
                     /db_xref="CDD:440243"
     CDS             1..452
                     /gene="SLC9D1"
                     /gene_synonym="C13orf11; TMCO3"
                     /coded_by="XM_047430413.1:990..2348"
                     /db_xref="GeneID:55002"
                     /db_xref="HGNC:HGNC:20329"
                     /db_xref="MIM:617134"
ORIGIN      
        1 mitkssrdla envcltckls gaetrgllcp alrtwimkvl grsffwvlfp vlpwavqave
       61 heevaqrvik lhrgrgvaam qsrqwvrdsc rklsgllrqk navlnklkta igavekdvgl
      121 sdeeklfqvh tfeifqkeln esensvfqav yglqralqgd ykdvvnmkes srqrlealre
      181 aaikeeteym ellaaekhqv ealknmqhqn qslsmldeil edvrkaadrl eeeieehafd
      241 dnksvkgvnf eavlrveeee anskqnitkr eveddlglsm lidsqnnqyi ltkprdstip
      301 radhhfikdi vtigmlslpc gwlctaiglp tmfgyiicgv llgpsglnsi ksivqvetlg
      361 efgvfftlfl vglefspekl rkvwkislqg pcymtllmia fgllwghllr ikptqsvfis
      421 tclslsstpl vsrflmgsar gdkeelflsl fs
//
LOCUS       XP_047286370             452 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane and coiled-coil domain-containing protein 3 isoform
            X16 [Homo sapiens].
ACCESSION   XP_047286370
VERSION     XP_047286370.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430414.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..452
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..452
                     /product="transmembrane and coiled-coil domain-containing
                     protein 3 isoform X16"
                     /calculated_mol_wt=51016
     Region          304..>383
                     /region_name="KefB"
                     /note="Kef-type K+ transport system, membrane component
                     KefB [Inorganic ion transport and metabolism]; COG0475"
                     /db_xref="CDD:440243"
     CDS             1..452
                     /gene="SLC9D1"
                     /gene_synonym="C13orf11; TMCO3"
                     /coded_by="XM_047430414.1:990..2348"
                     /db_xref="GeneID:55002"
                     /db_xref="HGNC:HGNC:20329"
                     /db_xref="MIM:617134"
ORIGIN      
        1 mitkssrdla envcltckls gaetrgllcp alrtwimkvl grsffwvlfp vlpwavqave
       61 heevaqrvik lhrgrgvaam qsrqwvrdsc rklsgllrqk navlnklkta igavekdvgl
      121 sdeeklfqvh tfeifqkeln esensvfqav yglqralqgd ykdvvnmkes srqrlealre
      181 aaikeeteym ellaaekhqv ealknmqhqn qslsmldeil edvrkaadrl eeeieehafd
      241 dnksvkgvnf eavlrveeee anskqnitkr eveddlglsm lidsqnnqyi ltkprdstip
      301 radhhfikdi vtigmlslpc gwlctaiglp tmfgyiicgv llgpsglnsi ksivqvetlg
      361 efgvfftlfl vglefspekl rkhcrgsspn pgfdwsdsff tsggfsfmsc ykevshwtll
      421 seaahgkqge qrnpdlgnic lyllnvneyf sl
//
LOCUS       XP_047286371             447 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane and coiled-coil domain-containing protein 3 isoform
            X17 [Homo sapiens].
ACCESSION   XP_047286371
VERSION     XP_047286371.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430415.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..447
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..447
                     /product="transmembrane and coiled-coil domain-containing
                     protein 3 isoform X17"
                     /calculated_mol_wt=50291
     Region          304..>436
                     /region_name="KefB"
                     /note="Kef-type K+ transport system, membrane component
                     KefB [Inorganic ion transport and metabolism]; COG0475"
                     /db_xref="CDD:440243"
     CDS             1..447
                     /gene="SLC9D1"
                     /gene_synonym="C13orf11; TMCO3"
                     /coded_by="XM_047430415.1:990..2333"
                     /db_xref="GeneID:55002"
                     /db_xref="HGNC:HGNC:20329"
                     /db_xref="MIM:617134"
ORIGIN      
        1 mitkssrdla envcltckls gaetrgllcp alrtwimkvl grsffwvlfp vlpwavqave
       61 heevaqrvik lhrgrgvaam qsrqwvrdsc rklsgllrqk navlnklkta igavekdvgl
      121 sdeeklfqvh tfeifqkeln esensvfqav yglqralqgd ykdvvnmkes srqrlealre
      181 aaikeeteym ellaaekhqv ealknmqhqn qslsmldeil edvrkaadrl eeeieehafd
      241 dnksvkgvnf eavlrveeee anskqnitkr eveddlglsm lidsqnnqyi ltkprdstip
      301 radhhfikdi vtigmlslpc gwlctaiglp tmfgyiicgv llgpsglnsi ksivqvetlg
      361 efgvfftlfl vglefspekl rkvwkislqg pcymtllmia fgllwghllr ikptqsvfis
      421 tclslsstpl vsrflmgsar gdkegls
//
LOCUS       XP_011533429             643 aa            linear   PRI 05-AUG-2025
DEFINITION  ecto-NOX disulfide-thiol exchanger 1 isoform X1 [Homo sapiens].
ACCESSION   XP_011533429
VERSION     XP_011533429.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535127.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..643
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..643
                     /product="ecto-NOX disulfide-thiol exchanger 1 isoform X1"
                     /calculated_mol_wt=73218
     Region          136..219
                     /region_name="RRM_ENOX"
                     /note="RNA recognition motif (RRM) found in the cell
                     surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or
                     ENOX) proteins; cd12228"
                     /db_xref="CDD:409675"
     Region          235..>582
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..643
                     /gene="ENOX1"
                     /gene_synonym="bA64J21.1; cCNOX; CNOX; PIG38"
                     /coded_by="XM_011535127.4:713..2644"
                     /db_xref="GeneID:55068"
                     /db_xref="HGNC:HGNC:25474"
                     /db_xref="MIM:610914"
ORIGIN      
        1 mvdaggveni tqlpqelpqm maaaadglgs iaidttqlnm svtdptawat amnnlgmvpv
       61 glpgqqlvsd sicvpgfdps lnmmtgitpi npmipglglv ppppptevav vkeiihcksc
      121 tlfpqnpnlp ppstrerppg cktvfvgglp enateeiiqe vfeqcgdita irkskknfch
      181 irfaeefmvd kaiylsgyrm rlgsstdkkd sgrlhvdfaq arddfyewec kqrmrareer
      241 hrrkleedrl rppsppaimh yseheaalla eklkddskfs eaitvllswi ergevnrrsa
      301 nqfysmvqsa nshvrrlmne katheqemee akenfknalt giltqfeqiv avfnastrqk
      361 awdhfskaqr knidiwrkhs eelrnaqseq lmgirreeem emsddencds ptkkmrvdes
      421 alaaqayalk eendslrwql dayrnevell kqekeqlfrt eenltkdqql qflqqtmqgm
      481 qqqlltiqee lnnkkseleq akeeqshtqa llkvlqeqlk gtkelvetng hshedsnein
      541 vltvalvnqd renniekrsq glksekeall igiistflhv hpfganieyl wsymqqldsk
      601 isaneiemll mrlprmfkqe ftgvgatlek rwklcafegi ktt
//
LOCUS       XP_024305141             643 aa            linear   PRI 05-AUG-2025
DEFINITION  ecto-NOX disulfide-thiol exchanger 1 isoform X1 [Homo sapiens].
ACCESSION   XP_024305141
VERSION     XP_024305141.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449373.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..643
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..643
                     /product="ecto-NOX disulfide-thiol exchanger 1 isoform X1"
                     /calculated_mol_wt=73218
     Region          136..219
                     /region_name="RRM_ENOX"
                     /note="RNA recognition motif (RRM) found in the cell
                     surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or
                     ENOX) proteins; cd12228"
                     /db_xref="CDD:409675"
     Region          235..>582
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..643
                     /gene="ENOX1"
                     /gene_synonym="bA64J21.1; cCNOX; CNOX; PIG38"
                     /coded_by="XM_024449373.2:772..2703"
                     /db_xref="GeneID:55068"
                     /db_xref="HGNC:HGNC:25474"
                     /db_xref="MIM:610914"
ORIGIN      
        1 mvdaggveni tqlpqelpqm maaaadglgs iaidttqlnm svtdptawat amnnlgmvpv
       61 glpgqqlvsd sicvpgfdps lnmmtgitpi npmipglglv ppppptevav vkeiihcksc
      121 tlfpqnpnlp ppstrerppg cktvfvgglp enateeiiqe vfeqcgdita irkskknfch
      181 irfaeefmvd kaiylsgyrm rlgsstdkkd sgrlhvdfaq arddfyewec kqrmrareer
      241 hrrkleedrl rppsppaimh yseheaalla eklkddskfs eaitvllswi ergevnrrsa
      301 nqfysmvqsa nshvrrlmne katheqemee akenfknalt giltqfeqiv avfnastrqk
      361 awdhfskaqr knidiwrkhs eelrnaqseq lmgirreeem emsddencds ptkkmrvdes
      421 alaaqayalk eendslrwql dayrnevell kqekeqlfrt eenltkdqql qflqqtmqgm
      481 qqqlltiqee lnnkkseleq akeeqshtqa llkvlqeqlk gtkelvetng hshedsnein
      541 vltvalvnqd renniekrsq glksekeall igiistflhv hpfganieyl wsymqqldsk
      601 isaneiemll mrlprmfkqe ftgvgatlek rwklcafegi ktt
//
LOCUS       XP_047286372             643 aa            linear   PRI 05-AUG-2025
DEFINITION  ecto-NOX disulfide-thiol exchanger 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047286372
VERSION     XP_047286372.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430416.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..643
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..643
                     /product="ecto-NOX disulfide-thiol exchanger 1 isoform X1"
                     /calculated_mol_wt=73218
     Region          136..219
                     /region_name="RRM_ENOX"
                     /note="RNA recognition motif (RRM) found in the cell
                     surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or
                     ENOX) proteins; cd12228"
                     /db_xref="CDD:409675"
     Region          235..>582
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..643
                     /gene="ENOX1"
                     /gene_synonym="bA64J21.1; cCNOX; CNOX; PIG38"
                     /coded_by="XM_047430416.1:501..2432"
                     /db_xref="GeneID:55068"
                     /db_xref="HGNC:HGNC:25474"
                     /db_xref="MIM:610914"
ORIGIN      
        1 mvdaggveni tqlpqelpqm maaaadglgs iaidttqlnm svtdptawat amnnlgmvpv
       61 glpgqqlvsd sicvpgfdps lnmmtgitpi npmipglglv ppppptevav vkeiihcksc
      121 tlfpqnpnlp ppstrerppg cktvfvgglp enateeiiqe vfeqcgdita irkskknfch
      181 irfaeefmvd kaiylsgyrm rlgsstdkkd sgrlhvdfaq arddfyewec kqrmrareer
      241 hrrkleedrl rppsppaimh yseheaalla eklkddskfs eaitvllswi ergevnrrsa
      301 nqfysmvqsa nshvrrlmne katheqemee akenfknalt giltqfeqiv avfnastrqk
      361 awdhfskaqr knidiwrkhs eelrnaqseq lmgirreeem emsddencds ptkkmrvdes
      421 alaaqayalk eendslrwql dayrnevell kqekeqlfrt eenltkdqql qflqqtmqgm
      481 qqqlltiqee lnnkkseleq akeeqshtqa llkvlqeqlk gtkelvetng hshedsnein
      541 vltvalvnqd renniekrsq glksekeall igiistflhv hpfganieyl wsymqqldsk
      601 isaneiemll mrlprmfkqe ftgvgatlek rwklcafegi ktt
//
LOCUS       XP_047286373             643 aa            linear   PRI 05-AUG-2025
DEFINITION  ecto-NOX disulfide-thiol exchanger 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047286373
VERSION     XP_047286373.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430417.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..643
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..643
                     /product="ecto-NOX disulfide-thiol exchanger 1 isoform X1"
                     /calculated_mol_wt=73218
     Region          136..219
                     /region_name="RRM_ENOX"
                     /note="RNA recognition motif (RRM) found in the cell
                     surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or
                     ENOX) proteins; cd12228"
                     /db_xref="CDD:409675"
     Region          235..>582
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..643
                     /gene="ENOX1"
                     /gene_synonym="bA64J21.1; cCNOX; CNOX; PIG38"
                     /coded_by="XM_047430417.1:31400..33331"
                     /db_xref="GeneID:55068"
                     /db_xref="HGNC:HGNC:25474"
                     /db_xref="MIM:610914"
ORIGIN      
        1 mvdaggveni tqlpqelpqm maaaadglgs iaidttqlnm svtdptawat amnnlgmvpv
       61 glpgqqlvsd sicvpgfdps lnmmtgitpi npmipglglv ppppptevav vkeiihcksc
      121 tlfpqnpnlp ppstrerppg cktvfvgglp enateeiiqe vfeqcgdita irkskknfch
      181 irfaeefmvd kaiylsgyrm rlgsstdkkd sgrlhvdfaq arddfyewec kqrmrareer
      241 hrrkleedrl rppsppaimh yseheaalla eklkddskfs eaitvllswi ergevnrrsa
      301 nqfysmvqsa nshvrrlmne katheqemee akenfknalt giltqfeqiv avfnastrqk
      361 awdhfskaqr knidiwrkhs eelrnaqseq lmgirreeem emsddencds ptkkmrvdes
      421 alaaqayalk eendslrwql dayrnevell kqekeqlfrt eenltkdqql qflqqtmqgm
      481 qqqlltiqee lnnkkseleq akeeqshtqa llkvlqeqlk gtkelvetng hshedsnein
      541 vltvalvnqd renniekrsq glksekeall igiistflhv hpfganieyl wsymqqldsk
      601 isaneiemll mrlprmfkqe ftgvgatlek rwklcafegi ktt
//
LOCUS       XP_047286374             643 aa            linear   PRI 05-AUG-2025
DEFINITION  ecto-NOX disulfide-thiol exchanger 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047286374
VERSION     XP_047286374.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430418.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..643
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..643
                     /product="ecto-NOX disulfide-thiol exchanger 1 isoform X1"
                     /calculated_mol_wt=73218
     Region          136..219
                     /region_name="RRM_ENOX"
                     /note="RNA recognition motif (RRM) found in the cell
                     surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or
                     ENOX) proteins; cd12228"
                     /db_xref="CDD:409675"
     Region          235..>582
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..643
                     /gene="ENOX1"
                     /gene_synonym="bA64J21.1; cCNOX; CNOX; PIG38"
                     /coded_by="XM_047430418.1:32486..34417"
                     /db_xref="GeneID:55068"
                     /db_xref="HGNC:HGNC:25474"
                     /db_xref="MIM:610914"
ORIGIN      
        1 mvdaggveni tqlpqelpqm maaaadglgs iaidttqlnm svtdptawat amnnlgmvpv
       61 glpgqqlvsd sicvpgfdps lnmmtgitpi npmipglglv ppppptevav vkeiihcksc
      121 tlfpqnpnlp ppstrerppg cktvfvgglp enateeiiqe vfeqcgdita irkskknfch
      181 irfaeefmvd kaiylsgyrm rlgsstdkkd sgrlhvdfaq arddfyewec kqrmrareer
      241 hrrkleedrl rppsppaimh yseheaalla eklkddskfs eaitvllswi ergevnrrsa
      301 nqfysmvqsa nshvrrlmne katheqemee akenfknalt giltqfeqiv avfnastrqk
      361 awdhfskaqr knidiwrkhs eelrnaqseq lmgirreeem emsddencds ptkkmrvdes
      421 alaaqayalk eendslrwql dayrnevell kqekeqlfrt eenltkdqql qflqqtmqgm
      481 qqqlltiqee lnnkkseleq akeeqshtqa llkvlqeqlk gtkelvetng hshedsnein
      541 vltvalvnqd renniekrsq glksekeall igiistflhv hpfganieyl wsymqqldsk
      601 isaneiemll mrlprmfkqe ftgvgatlek rwklcafegi ktt
//
LOCUS       XP_047286375             643 aa            linear   PRI 05-AUG-2025
DEFINITION  ecto-NOX disulfide-thiol exchanger 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047286375
VERSION     XP_047286375.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430419.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..643
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..643
                     /product="ecto-NOX disulfide-thiol exchanger 1 isoform X1"
                     /calculated_mol_wt=73218
     Region          136..219
                     /region_name="RRM_ENOX"
                     /note="RNA recognition motif (RRM) found in the cell
                     surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or
                     ENOX) proteins; cd12228"
                     /db_xref="CDD:409675"
     Region          235..>582
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..643
                     /gene="ENOX1"
                     /gene_synonym="bA64J21.1; cCNOX; CNOX; PIG38"
                     /coded_by="XM_047430419.1:32449..34380"
                     /db_xref="GeneID:55068"
                     /db_xref="HGNC:HGNC:25474"
                     /db_xref="MIM:610914"
ORIGIN      
        1 mvdaggveni tqlpqelpqm maaaadglgs iaidttqlnm svtdptawat amnnlgmvpv
       61 glpgqqlvsd sicvpgfdps lnmmtgitpi npmipglglv ppppptevav vkeiihcksc
      121 tlfpqnpnlp ppstrerppg cktvfvgglp enateeiiqe vfeqcgdita irkskknfch
      181 irfaeefmvd kaiylsgyrm rlgsstdkkd sgrlhvdfaq arddfyewec kqrmrareer
      241 hrrkleedrl rppsppaimh yseheaalla eklkddskfs eaitvllswi ergevnrrsa
      301 nqfysmvqsa nshvrrlmne katheqemee akenfknalt giltqfeqiv avfnastrqk
      361 awdhfskaqr knidiwrkhs eelrnaqseq lmgirreeem emsddencds ptkkmrvdes
      421 alaaqayalk eendslrwql dayrnevell kqekeqlfrt eenltkdqql qflqqtmqgm
      481 qqqlltiqee lnnkkseleq akeeqshtqa llkvlqeqlk gtkelvetng hshedsnein
      541 vltvalvnqd renniekrsq glksekeall igiistflhv hpfganieyl wsymqqldsk
      601 isaneiemll mrlprmfkqe ftgvgatlek rwklcafegi ktt
//
LOCUS       XP_047286376             643 aa            linear   PRI 05-AUG-2025
DEFINITION  ecto-NOX disulfide-thiol exchanger 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047286376
VERSION     XP_047286376.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430420.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..643
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..643
                     /product="ecto-NOX disulfide-thiol exchanger 1 isoform X1"
                     /calculated_mol_wt=73218
     Region          136..219
                     /region_name="RRM_ENOX"
                     /note="RNA recognition motif (RRM) found in the cell
                     surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or
                     ENOX) proteins; cd12228"
                     /db_xref="CDD:409675"
     Region          235..>582
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..643
                     /gene="ENOX1"
                     /gene_synonym="bA64J21.1; cCNOX; CNOX; PIG38"
                     /coded_by="XM_047430420.1:31319..33250"
                     /db_xref="GeneID:55068"
                     /db_xref="HGNC:HGNC:25474"
                     /db_xref="MIM:610914"
ORIGIN      
        1 mvdaggveni tqlpqelpqm maaaadglgs iaidttqlnm svtdptawat amnnlgmvpv
       61 glpgqqlvsd sicvpgfdps lnmmtgitpi npmipglglv ppppptevav vkeiihcksc
      121 tlfpqnpnlp ppstrerppg cktvfvgglp enateeiiqe vfeqcgdita irkskknfch
      181 irfaeefmvd kaiylsgyrm rlgsstdkkd sgrlhvdfaq arddfyewec kqrmrareer
      241 hrrkleedrl rppsppaimh yseheaalla eklkddskfs eaitvllswi ergevnrrsa
      301 nqfysmvqsa nshvrrlmne katheqemee akenfknalt giltqfeqiv avfnastrqk
      361 awdhfskaqr knidiwrkhs eelrnaqseq lmgirreeem emsddencds ptkkmrvdes
      421 alaaqayalk eendslrwql dayrnevell kqekeqlfrt eenltkdqql qflqqtmqgm
      481 qqqlltiqee lnnkkseleq akeeqshtqa llkvlqeqlk gtkelvetng hshedsnein
      541 vltvalvnqd renniekrsq glksekeall igiistflhv hpfganieyl wsymqqldsk
      601 isaneiemll mrlprmfkqe ftgvgatlek rwklcafegi ktt
//
LOCUS       XP_047286377             643 aa            linear   PRI 05-AUG-2025
DEFINITION  ecto-NOX disulfide-thiol exchanger 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047286377
VERSION     XP_047286377.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430421.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..643
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..643
                     /product="ecto-NOX disulfide-thiol exchanger 1 isoform X1"
                     /calculated_mol_wt=73218
     Region          136..219
                     /region_name="RRM_ENOX"
                     /note="RNA recognition motif (RRM) found in the cell
                     surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or
                     ENOX) proteins; cd12228"
                     /db_xref="CDD:409675"
     Region          235..>582
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..643
                     /gene="ENOX1"
                     /gene_synonym="bA64J21.1; cCNOX; CNOX; PIG38"
                     /coded_by="XM_047430421.1:21628..23559"
                     /db_xref="GeneID:55068"
                     /db_xref="HGNC:HGNC:25474"
                     /db_xref="MIM:610914"
ORIGIN      
        1 mvdaggveni tqlpqelpqm maaaadglgs iaidttqlnm svtdptawat amnnlgmvpv
       61 glpgqqlvsd sicvpgfdps lnmmtgitpi npmipglglv ppppptevav vkeiihcksc
      121 tlfpqnpnlp ppstrerppg cktvfvgglp enateeiiqe vfeqcgdita irkskknfch
      181 irfaeefmvd kaiylsgyrm rlgsstdkkd sgrlhvdfaq arddfyewec kqrmrareer
      241 hrrkleedrl rppsppaimh yseheaalla eklkddskfs eaitvllswi ergevnrrsa
      301 nqfysmvqsa nshvrrlmne katheqemee akenfknalt giltqfeqiv avfnastrqk
      361 awdhfskaqr knidiwrkhs eelrnaqseq lmgirreeem emsddencds ptkkmrvdes
      421 alaaqayalk eendslrwql dayrnevell kqekeqlfrt eenltkdqql qflqqtmqgm
      481 qqqlltiqee lnnkkseleq akeeqshtqa llkvlqeqlk gtkelvetng hshedsnein
      541 vltvalvnqd renniekrsq glksekeall igiistflhv hpfganieyl wsymqqldsk
      601 isaneiemll mrlprmfkqe ftgvgatlek rwklcafegi ktt
//
LOCUS       XP_047286378             643 aa            linear   PRI 05-AUG-2025
DEFINITION  ecto-NOX disulfide-thiol exchanger 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047286378
VERSION     XP_047286378.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430422.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..643
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..643
                     /product="ecto-NOX disulfide-thiol exchanger 1 isoform X1"
                     /calculated_mol_wt=73218
     Region          136..219
                     /region_name="RRM_ENOX"
                     /note="RNA recognition motif (RRM) found in the cell
                     surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or
                     ENOX) proteins; cd12228"
                     /db_xref="CDD:409675"
     Region          235..>582
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..643
                     /gene="ENOX1"
                     /gene_synonym="bA64J21.1; cCNOX; CNOX; PIG38"
                     /coded_by="XM_047430422.1:31180..33111"
                     /db_xref="GeneID:55068"
                     /db_xref="HGNC:HGNC:25474"
                     /db_xref="MIM:610914"
ORIGIN      
        1 mvdaggveni tqlpqelpqm maaaadglgs iaidttqlnm svtdptawat amnnlgmvpv
       61 glpgqqlvsd sicvpgfdps lnmmtgitpi npmipglglv ppppptevav vkeiihcksc
      121 tlfpqnpnlp ppstrerppg cktvfvgglp enateeiiqe vfeqcgdita irkskknfch
      181 irfaeefmvd kaiylsgyrm rlgsstdkkd sgrlhvdfaq arddfyewec kqrmrareer
      241 hrrkleedrl rppsppaimh yseheaalla eklkddskfs eaitvllswi ergevnrrsa
      301 nqfysmvqsa nshvrrlmne katheqemee akenfknalt giltqfeqiv avfnastrqk
      361 awdhfskaqr knidiwrkhs eelrnaqseq lmgirreeem emsddencds ptkkmrvdes
      421 alaaqayalk eendslrwql dayrnevell kqekeqlfrt eenltkdqql qflqqtmqgm
      481 qqqlltiqee lnnkkseleq akeeqshtqa llkvlqeqlk gtkelvetng hshedsnein
      541 vltvalvnqd renniekrsq glksekeall igiistflhv hpfganieyl wsymqqldsk
      601 isaneiemll mrlprmfkqe ftgvgatlek rwklcafegi ktt
//
LOCUS       XP_047286379             643 aa            linear   PRI 05-AUG-2025
DEFINITION  ecto-NOX disulfide-thiol exchanger 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047286379
VERSION     XP_047286379.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430423.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 1% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..643
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..643
                     /product="ecto-NOX disulfide-thiol exchanger 1 isoform X1"
                     /calculated_mol_wt=73218
     Region          136..219
                     /region_name="RRM_ENOX"
                     /note="RNA recognition motif (RRM) found in the cell
                     surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or
                     ENOX) proteins; cd12228"
                     /db_xref="CDD:409675"
     Region          235..>582
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..643
                     /gene="ENOX1"
                     /gene_synonym="bA64J21.1; cCNOX; CNOX; PIG38"
                     /coded_by="XM_047430423.1:484..2415"
                     /db_xref="GeneID:55068"
                     /db_xref="HGNC:HGNC:25474"
                     /db_xref="MIM:610914"
ORIGIN      
        1 mvdaggveni tqlpqelpqm maaaadglgs iaidttqlnm svtdptawat amnnlgmvpv
       61 glpgqqlvsd sicvpgfdps lnmmtgitpi npmipglglv ppppptevav vkeiihcksc
      121 tlfpqnpnlp ppstrerppg cktvfvgglp enateeiiqe vfeqcgdita irkskknfch
      181 irfaeefmvd kaiylsgyrm rlgsstdkkd sgrlhvdfaq arddfyewec kqrmrareer
      241 hrrkleedrl rppsppaimh yseheaalla eklkddskfs eaitvllswi ergevnrrsa
      301 nqfysmvqsa nshvrrlmne katheqemee akenfknalt giltqfeqiv avfnastrqk
      361 awdhfskaqr knidiwrkhs eelrnaqseq lmgirreeem emsddencds ptkkmrvdes
      421 alaaqayalk eendslrwql dayrnevell kqekeqlfrt eenltkdqql qflqqtmqgm
      481 qqqlltiqee lnnkkseleq akeeqshtqa llkvlqeqlk gtkelvetng hshedsnein
      541 vltvalvnqd renniekrsq glksekeall igiistflhv hpfganieyl wsymqqldsk
      601 isaneiemll mrlprmfkqe ftgvgatlek rwklcafegi ktt
//
LOCUS       XP_024305142             643 aa            linear   PRI 05-AUG-2025
DEFINITION  ecto-NOX disulfide-thiol exchanger 1 isoform X1 [Homo sapiens].
ACCESSION   XP_024305142
VERSION     XP_024305142.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449374.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..643
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..643
                     /product="ecto-NOX disulfide-thiol exchanger 1 isoform X1"
                     /calculated_mol_wt=73218
     Region          136..219
                     /region_name="RRM_ENOX"
                     /note="RNA recognition motif (RRM) found in the cell
                     surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or
                     ENOX) proteins; cd12228"
                     /db_xref="CDD:409675"
     Region          235..>582
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..643
                     /gene="ENOX1"
                     /gene_synonym="bA64J21.1; cCNOX; CNOX; PIG38"
                     /coded_by="XM_024449374.2:954..2885"
                     /db_xref="GeneID:55068"
                     /db_xref="HGNC:HGNC:25474"
                     /db_xref="MIM:610914"
ORIGIN      
        1 mvdaggveni tqlpqelpqm maaaadglgs iaidttqlnm svtdptawat amnnlgmvpv
       61 glpgqqlvsd sicvpgfdps lnmmtgitpi npmipglglv ppppptevav vkeiihcksc
      121 tlfpqnpnlp ppstrerppg cktvfvgglp enateeiiqe vfeqcgdita irkskknfch
      181 irfaeefmvd kaiylsgyrm rlgsstdkkd sgrlhvdfaq arddfyewec kqrmrareer
      241 hrrkleedrl rppsppaimh yseheaalla eklkddskfs eaitvllswi ergevnrrsa
      301 nqfysmvqsa nshvrrlmne katheqemee akenfknalt giltqfeqiv avfnastrqk
      361 awdhfskaqr knidiwrkhs eelrnaqseq lmgirreeem emsddencds ptkkmrvdes
      421 alaaqayalk eendslrwql dayrnevell kqekeqlfrt eenltkdqql qflqqtmqgm
      481 qqqlltiqee lnnkkseleq akeeqshtqa llkvlqeqlk gtkelvetng hshedsnein
      541 vltvalvnqd renniekrsq glksekeall igiistflhv hpfganieyl wsymqqldsk
      601 isaneiemll mrlprmfkqe ftgvgatlek rwklcafegi ktt
//
LOCUS       XP_047286380             624 aa            linear   PRI 05-AUG-2025
DEFINITION  ecto-NOX disulfide-thiol exchanger 1 isoform X2 [Homo sapiens].
ACCESSION   XP_047286380
VERSION     XP_047286380.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430424.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..624
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..624
                     /product="ecto-NOX disulfide-thiol exchanger 1 isoform X2"
                     /calculated_mol_wt=71140
     Region          136..219
                     /region_name="RRM_ENOX"
                     /note="RNA recognition motif (RRM) found in the cell
                     surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or
                     ENOX) proteins; cd12228"
                     /db_xref="CDD:409675"
     Region          235..>563
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          <418..>551
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     CDS             1..624
                     /gene="ENOX1"
                     /gene_synonym="bA64J21.1; cCNOX; CNOX; PIG38"
                     /coded_by="XM_047430424.1:606..2480"
                     /db_xref="GeneID:55068"
                     /db_xref="HGNC:HGNC:25474"
                     /db_xref="MIM:610914"
ORIGIN      
        1 mvdaggveni tqlpqelpqm maaaadglgs iaidttqlnm svtdptawat amnnlgmvpv
       61 glpgqqlvsd sicvpgfdps lnmmtgitpi npmipglglv ppppptevav vkeiihcksc
      121 tlfpqnpnlp ppstrerppg cktvfvgglp enateeiiqe vfeqcgdita irkskknfch
      181 irfaeefmvd kaiylsgyrm rlgsstdkkd sgrlhvdfaq arddfyewec kqrmrareer
      241 hrrkleedrl rppsppaimh yseheaalla eklkddskfs eaitvllswi ergevnrrsa
      301 nqfysmvqsa nshvrrlmne katheqemee akenfknalt giltqfeqiv avfnastrqk
      361 awdhfskaqr knidiwrkhs eelrnaqseq lmgirreeem emsddencds ptkkmrvdes
      421 alaaqayalk eendslrwql dayrnevell kqekeqlfrt eenltkdqql qflqqtmqgm
      481 qqqlltiqee lnnkkseleq akeeqshtqa llkvlqeqei nvltvalvnq drenniekrs
      541 qglksekeal ligiistflh vhpfganiey lwsymqqlds kisaneieml lmrlprmfkq
      601 eftgvgatle krwklcafeg iktt
//
LOCUS       XP_047286381             624 aa            linear   PRI 05-AUG-2025
DEFINITION  ecto-NOX disulfide-thiol exchanger 1 isoform X2 [Homo sapiens].
ACCESSION   XP_047286381
VERSION     XP_047286381.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430425.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..624
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..624
                     /product="ecto-NOX disulfide-thiol exchanger 1 isoform X2"
                     /calculated_mol_wt=71140
     Region          136..219
                     /region_name="RRM_ENOX"
                     /note="RNA recognition motif (RRM) found in the cell
                     surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or
                     ENOX) proteins; cd12228"
                     /db_xref="CDD:409675"
     Region          235..>563
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          <418..>551
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     CDS             1..624
                     /gene="ENOX1"
                     /gene_synonym="bA64J21.1; cCNOX; CNOX; PIG38"
                     /coded_by="XM_047430425.1:643..2517"
                     /db_xref="GeneID:55068"
                     /db_xref="HGNC:HGNC:25474"
                     /db_xref="MIM:610914"
ORIGIN      
        1 mvdaggveni tqlpqelpqm maaaadglgs iaidttqlnm svtdptawat amnnlgmvpv
       61 glpgqqlvsd sicvpgfdps lnmmtgitpi npmipglglv ppppptevav vkeiihcksc
      121 tlfpqnpnlp ppstrerppg cktvfvgglp enateeiiqe vfeqcgdita irkskknfch
      181 irfaeefmvd kaiylsgyrm rlgsstdkkd sgrlhvdfaq arddfyewec kqrmrareer
      241 hrrkleedrl rppsppaimh yseheaalla eklkddskfs eaitvllswi ergevnrrsa
      301 nqfysmvqsa nshvrrlmne katheqemee akenfknalt giltqfeqiv avfnastrqk
      361 awdhfskaqr knidiwrkhs eelrnaqseq lmgirreeem emsddencds ptkkmrvdes
      421 alaaqayalk eendslrwql dayrnevell kqekeqlfrt eenltkdqql qflqqtmqgm
      481 qqqlltiqee lnnkkseleq akeeqshtqa llkvlqeqei nvltvalvnq drenniekrs
      541 qglksekeal ligiistflh vhpfganiey lwsymqqlds kisaneieml lmrlprmfkq
      601 eftgvgatle krwklcafeg iktt
//
LOCUS       XP_047286382             624 aa            linear   PRI 05-AUG-2025
DEFINITION  ecto-NOX disulfide-thiol exchanger 1 isoform X2 [Homo sapiens].
ACCESSION   XP_047286382
VERSION     XP_047286382.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430426.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..624
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..624
                     /product="ecto-NOX disulfide-thiol exchanger 1 isoform X2"
                     /calculated_mol_wt=71140
     Region          136..219
                     /region_name="RRM_ENOX"
                     /note="RNA recognition motif (RRM) found in the cell
                     surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or
                     ENOX) proteins; cd12228"
                     /db_xref="CDD:409675"
     Region          235..>563
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          <418..>551
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     CDS             1..624
                     /gene="ENOX1"
                     /gene_synonym="bA64J21.1; cCNOX; CNOX; PIG38"
                     /coded_by="XM_047430426.1:713..2587"
                     /db_xref="GeneID:55068"
                     /db_xref="HGNC:HGNC:25474"
                     /db_xref="MIM:610914"
ORIGIN      
        1 mvdaggveni tqlpqelpqm maaaadglgs iaidttqlnm svtdptawat amnnlgmvpv
       61 glpgqqlvsd sicvpgfdps lnmmtgitpi npmipglglv ppppptevav vkeiihcksc
      121 tlfpqnpnlp ppstrerppg cktvfvgglp enateeiiqe vfeqcgdita irkskknfch
      181 irfaeefmvd kaiylsgyrm rlgsstdkkd sgrlhvdfaq arddfyewec kqrmrareer
      241 hrrkleedrl rppsppaimh yseheaalla eklkddskfs eaitvllswi ergevnrrsa
      301 nqfysmvqsa nshvrrlmne katheqemee akenfknalt giltqfeqiv avfnastrqk
      361 awdhfskaqr knidiwrkhs eelrnaqseq lmgirreeem emsddencds ptkkmrvdes
      421 alaaqayalk eendslrwql dayrnevell kqekeqlfrt eenltkdqql qflqqtmqgm
      481 qqqlltiqee lnnkkseleq akeeqshtqa llkvlqeqei nvltvalvnq drenniekrs
      541 qglksekeal ligiistflh vhpfganiey lwsymqqlds kisaneieml lmrlprmfkq
      601 eftgvgatle krwklcafeg iktt
//
LOCUS       XP_047286383             624 aa            linear   PRI 05-AUG-2025
DEFINITION  ecto-NOX disulfide-thiol exchanger 1 isoform X2 [Homo sapiens].
ACCESSION   XP_047286383
VERSION     XP_047286383.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430427.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..624
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..624
                     /product="ecto-NOX disulfide-thiol exchanger 1 isoform X2"
                     /calculated_mol_wt=71140
     Region          136..219
                     /region_name="RRM_ENOX"
                     /note="RNA recognition motif (RRM) found in the cell
                     surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or
                     ENOX) proteins; cd12228"
                     /db_xref="CDD:409675"
     Region          235..>563
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          <418..>551
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     CDS             1..624
                     /gene="ENOX1"
                     /gene_synonym="bA64J21.1; cCNOX; CNOX; PIG38"
                     /coded_by="XM_047430427.1:617..2491"
                     /db_xref="GeneID:55068"
                     /db_xref="HGNC:HGNC:25474"
                     /db_xref="MIM:610914"
ORIGIN      
        1 mvdaggveni tqlpqelpqm maaaadglgs iaidttqlnm svtdptawat amnnlgmvpv
       61 glpgqqlvsd sicvpgfdps lnmmtgitpi npmipglglv ppppptevav vkeiihcksc
      121 tlfpqnpnlp ppstrerppg cktvfvgglp enateeiiqe vfeqcgdita irkskknfch
      181 irfaeefmvd kaiylsgyrm rlgsstdkkd sgrlhvdfaq arddfyewec kqrmrareer
      241 hrrkleedrl rppsppaimh yseheaalla eklkddskfs eaitvllswi ergevnrrsa
      301 nqfysmvqsa nshvrrlmne katheqemee akenfknalt giltqfeqiv avfnastrqk
      361 awdhfskaqr knidiwrkhs eelrnaqseq lmgirreeem emsddencds ptkkmrvdes
      421 alaaqayalk eendslrwql dayrnevell kqekeqlfrt eenltkdqql qflqqtmqgm
      481 qqqlltiqee lnnkkseleq akeeqshtqa llkvlqeqei nvltvalvnq drenniekrs
      541 qglksekeal ligiistflh vhpfganiey lwsymqqlds kisaneieml lmrlprmfkq
      601 eftgvgatle krwklcafeg iktt
//
LOCUS       XP_047286384             424 aa            linear   PRI 05-AUG-2025
DEFINITION  ecto-NOX disulfide-thiol exchanger 1 isoform X3 [Homo sapiens].
ACCESSION   XP_047286384
VERSION     XP_047286384.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430428.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..424
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..424
                     /product="ecto-NOX disulfide-thiol exchanger 1 isoform X3"
                     /calculated_mol_wt=47742
     Region          136..219
                     /region_name="RRM_ENOX"
                     /note="RNA recognition motif (RRM) found in the cell
                     surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or
                     ENOX) proteins; cd12228"
                     /db_xref="CDD:409675"
     CDS             1..424
                     /gene="ENOX1"
                     /gene_synonym="bA64J21.1; cCNOX; CNOX; PIG38"
                     /coded_by="XM_047430428.1:31400..32674"
                     /db_xref="GeneID:55068"
                     /db_xref="HGNC:HGNC:25474"
                     /db_xref="MIM:610914"
ORIGIN      
        1 mvdaggveni tqlpqelpqm maaaadglgs iaidttqlnm svtdptawat amnnlgmvpv
       61 glpgqqlvsd sicvpgfdps lnmmtgitpi npmipglglv ppppptevav vkeiihcksc
      121 tlfpqnpnlp ppstrerppg cktvfvgglp enateeiiqe vfeqcgdita irkskknfch
      181 irfaeefmvd kaiylsgyrm rlgsstdkkd sgrlhvdfaq arddfyewec kqrmrareer
      241 hrrkleedrl rppsppaimh yseheaalla eklkddskfs eaitvllswi ergevnrrsa
      301 nqfysmvqsa nshvrrlmne katheqemee akenfknalt giltqfeqiv avfnastrqk
      361 awdhfskaqr knidiwrkhs eelrnaqseq lmgirreeem emsddencds ptkkmrvdes
      421 glqd
//
LOCUS       XP_047286385             421 aa            linear   PRI 05-AUG-2025
DEFINITION  ecto-NOX disulfide-thiol exchanger 1 isoform X4 [Homo sapiens].
ACCESSION   XP_047286385
VERSION     XP_047286385.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430429.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..421
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..421
                     /product="ecto-NOX disulfide-thiol exchanger 1 isoform X4"
                     /calculated_mol_wt=47386
     Region          136..219
                     /region_name="RRM_ENOX"
                     /note="RNA recognition motif (RRM) found in the cell
                     surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or
                     ENOX) proteins; cd12228"
                     /db_xref="CDD:409675"
     CDS             1..421
                     /gene="ENOX1"
                     /gene_synonym="bA64J21.1; cCNOX; CNOX; PIG38"
                     /coded_by="XM_047430429.1:31400..32665"
                     /db_xref="GeneID:55068"
                     /db_xref="HGNC:HGNC:25474"
                     /db_xref="MIM:610914"
ORIGIN      
        1 mvdaggveni tqlpqelpqm maaaadglgs iaidttqlnm svtdptawat amnnlgmvpv
       61 glpgqqlvsd sicvpgfdps lnmmtgitpi npmipglglv ppppptevav vkeiihcksc
      121 tlfpqnpnlp ppstrerppg cktvfvgglp enateeiiqe vfeqcgdita irkskknfch
      181 irfaeefmvd kaiylsgyrm rlgsstdkkd sgrlhvdfaq arddfyewec kqrmrareer
      241 hrrkleedrl rppsppaimh yseheaalla eklkddskfs eaitvllswi ergevnrrsa
      301 nqfysmvqsa nshvrrlmne katheqemee akenfknalt giltqfeqiv avfnastrqk
      361 awdhfskaqr knidiwrkhs eelrnaqseq lmgirreeem emsddencds ptkkmrvdes
      421 g
//
LOCUS       XP_047286386             345 aa            linear   PRI 05-AUG-2025
DEFINITION  ecto-NOX disulfide-thiol exchanger 1 isoform X5 [Homo sapiens].
ACCESSION   XP_047286386
VERSION     XP_047286386.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430430.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..345
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..345
                     /product="ecto-NOX disulfide-thiol exchanger 1 isoform X5"
                     /calculated_mol_wt=38374
     Region          136..219
                     /region_name="RRM_ENOX"
                     /note="RNA recognition motif (RRM) found in the cell
                     surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or
                     ENOX) proteins; cd12228"
                     /db_xref="CDD:409675"
     CDS             1..345
                     /gene="ENOX1"
                     /gene_synonym="bA64J21.1; cCNOX; CNOX; PIG38"
                     /coded_by="XM_047430430.1:606..1643"
                     /db_xref="GeneID:55068"
                     /db_xref="HGNC:HGNC:25474"
                     /db_xref="MIM:610914"
ORIGIN      
        1 mvdaggveni tqlpqelpqm maaaadglgs iaidttqlnm svtdptawat amnnlgmvpv
       61 glpgqqlvsd sicvpgfdps lnmmtgitpi npmipglglv ppppptevav vkeiihcksc
      121 tlfpqnpnlp ppstrerppg cktvfvgglp enateeiiqe vfeqcgdita irkskknfch
      181 irfaeefmvd kaiylsgyrm rlgsstdkkd sgrlhvdfaq arddfyewec kqrmrareer
      241 hrrkleedrl rppsppaimh yseheaalla eklkddskfs eaitvllswi ergevnrrsa
      301 nqfysmvqsa nshvrrlmne katheqemee akenfknalt giltq
//
LOCUS       XP_016876132             337 aa            linear   PRI 05-AUG-2025
DEFINITION  DCN1-like protein 2 isoform X1 [Homo sapiens].
ACCESSION   XP_016876132
VERSION     XP_016876132.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020643.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..337
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..337
                     /product="DCN1-like protein 2 isoform X1"
                     /calculated_mol_wt=38211
     Region          80..126
                     /region_name="UBA_DCNL2"
                     /note="UBA-like domain found in DCN1-like protein 2
                     (DCNL2) and similar proteins; cd14412"
                     /db_xref="CDD:270595"
     Region          214..324
                     /region_name="Cullin_binding"
                     /note="Cullin binding; pfam03556"
                     /db_xref="CDD:460971"
     CDS             1..337
                     /gene="DCUN1D2"
                     /gene_synonym="C13orf17; DCNL2"
                     /coded_by="XM_017020643.2:43..1056"
                     /db_xref="GeneID:55208"
                     /db_xref="HGNC:HGNC:20328"
ORIGIN      
        1 mvggpasplp vgvgvgvgpq grrrrragcg rpspascagr sawirgrnap rareperwrr
       61 rrgtagsagl trsregrpgh klkssqkdkv rqfmactqag ertaiycltq newrldeatd
      121 sffqnpdslh resmrnavdk kklerlygry kdpqdenkig vdgiqqfcdd lsldpasisv
      181 lviawkfraa tqcefsrkef ldgmtelgcd smeklkallp rleqelkdta kfkdfyqftf
      241 tfaknpgqkg ldlemavayw klvlsgrfkf ldlwntflme hhkrsiprdt wnllldfgnm
      301 iaddmsnyde egawpvlidd fveyarpvvt ggkrslf
//
LOCUS       XP_047286387             244 aa            linear   PRI 05-AUG-2025
DEFINITION  DCN1-like protein 2 isoform X2 [Homo sapiens].
ACCESSION   XP_047286387
VERSION     XP_047286387.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430431.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..244
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..244
                     /product="DCN1-like protein 2 isoform X2"
                     /calculated_mol_wt=28206
     Region          <1..33
                     /region_name="UBA_like_SF"
                     /note="UBA domain-like superfamily; cl21463"
                     /db_xref="CDD:473871"
     Region          121..231
                     /region_name="Cullin_binding"
                     /note="Cullin binding; pfam03556"
                     /db_xref="CDD:460971"
     CDS             1..244
                     /gene="DCUN1D2"
                     /gene_synonym="C13orf17; DCNL2"
                     /coded_by="XM_047430431.1:1434..2168"
                     /db_xref="GeneID:55208"
                     /db_xref="HGNC:HGNC:20328"
ORIGIN      
        1 mactqagert aiycltqnew rldeatdsff qnpdslhres mrnavdkkkl erlygrykdp
       61 qdenkigvdg iqqfcddlsl dpasisvlvi awkfraatqc efsrkefldg mtelgcdsme
      121 klkallprle qelkdtakfk dfyqftftfa knpgqkgldl emavaywklv lsgrfkfldl
      181 wntflmehhk rsiprdtwnl lldfgnmiad dmsnydeega wpvliddfve yarpvvtggk
      241 rslf
//
LOCUS       XP_047286388             244 aa            linear   PRI 05-AUG-2025
DEFINITION  DCN1-like protein 2 isoform X2 [Homo sapiens].
ACCESSION   XP_047286388
VERSION     XP_047286388.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430432.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..244
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..244
                     /product="DCN1-like protein 2 isoform X2"
                     /calculated_mol_wt=28206
     Region          <1..33
                     /region_name="UBA_like_SF"
                     /note="UBA domain-like superfamily; cl21463"
                     /db_xref="CDD:473871"
     Region          121..231
                     /region_name="Cullin_binding"
                     /note="Cullin binding; pfam03556"
                     /db_xref="CDD:460971"
     CDS             1..244
                     /gene="DCUN1D2"
                     /gene_synonym="C13orf17; DCNL2"
                     /coded_by="XM_047430432.1:5066..5800"
                     /db_xref="GeneID:55208"
                     /db_xref="HGNC:HGNC:20328"
ORIGIN      
        1 mactqagert aiycltqnew rldeatdsff qnpdslhres mrnavdkkkl erlygrykdp
       61 qdenkigvdg iqqfcddlsl dpasisvlvi awkfraatqc efsrkefldg mtelgcdsme
      121 klkallprle qelkdtakfk dfyqftftfa knpgqkgldl emavaywklv lsgrfkfldl
      181 wntflmehhk rsiprdtwnl lldfgnmiad dmsnydeega wpvliddfve yarpvvtggk
      241 rslf
//
LOCUS       XP_016876133             244 aa            linear   PRI 05-AUG-2025
DEFINITION  DCN1-like protein 2 isoform X2 [Homo sapiens].
ACCESSION   XP_016876133
VERSION     XP_016876133.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020644.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..244
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..244
                     /product="DCN1-like protein 2 isoform X2"
                     /calculated_mol_wt=28206
     Region          <1..33
                     /region_name="UBA_like_SF"
                     /note="UBA domain-like superfamily; cl21463"
                     /db_xref="CDD:473871"
     Region          121..231
                     /region_name="Cullin_binding"
                     /note="Cullin binding; pfam03556"
                     /db_xref="CDD:460971"
     CDS             1..244
                     /gene="DCUN1D2"
                     /gene_synonym="C13orf17; DCNL2"
                     /coded_by="XM_017020644.2:228..962"
                     /db_xref="GeneID:55208"
                     /db_xref="HGNC:HGNC:20328"
ORIGIN      
        1 mactqagert aiycltqnew rldeatdsff qnpdslhres mrnavdkkkl erlygrykdp
       61 qdenkigvdg iqqfcddlsl dpasisvlvi awkfraatqc efsrkefldg mtelgcdsme
      121 klkallprle qelkdtakfk dfyqftftfa knpgqkgldl emavaywklv lsgrfkfldl
      181 wntflmehhk rsiprdtwnl lldfgnmiad dmsnydeega wpvliddfve yarpvvtggk
      241 rslf
//
LOCUS       XP_016876135             244 aa            linear   PRI 05-AUG-2025
DEFINITION  DCN1-like protein 2 isoform X2 [Homo sapiens].
ACCESSION   XP_016876135
VERSION     XP_016876135.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020646.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..244
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..244
                     /product="DCN1-like protein 2 isoform X2"
                     /calculated_mol_wt=28206
     Region          <1..33
                     /region_name="UBA_like_SF"
                     /note="UBA domain-like superfamily; cl21463"
                     /db_xref="CDD:473871"
     Region          121..231
                     /region_name="Cullin_binding"
                     /note="Cullin binding; pfam03556"
                     /db_xref="CDD:460971"
     CDS             1..244
                     /gene="DCUN1D2"
                     /gene_synonym="C13orf17; DCNL2"
                     /coded_by="XM_017020646.3:4926..5660"
                     /db_xref="GeneID:55208"
                     /db_xref="HGNC:HGNC:20328"
ORIGIN      
        1 mactqagert aiycltqnew rldeatdsff qnpdslhres mrnavdkkkl erlygrykdp
       61 qdenkigvdg iqqfcddlsl dpasisvlvi awkfraatqc efsrkefldg mtelgcdsme
      121 klkallprle qelkdtakfk dfyqftftfa knpgqkgldl emavaywklv lsgrfkfldl
      181 wntflmehhk rsiprdtwnl lldfgnmiad dmsnydeega wpvliddfve yarpvvtggk
      241 rslf
//
LOCUS       XP_016876136             244 aa            linear   PRI 05-AUG-2025
DEFINITION  DCN1-like protein 2 isoform X2 [Homo sapiens].
ACCESSION   XP_016876136
VERSION     XP_016876136.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020647.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..244
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..244
                     /product="DCN1-like protein 2 isoform X2"
                     /calculated_mol_wt=28206
     Region          <1..33
                     /region_name="UBA_like_SF"
                     /note="UBA domain-like superfamily; cl21463"
                     /db_xref="CDD:473871"
     Region          121..231
                     /region_name="Cullin_binding"
                     /note="Cullin binding; pfam03556"
                     /db_xref="CDD:460971"
     CDS             1..244
                     /gene="DCUN1D2"
                     /gene_synonym="C13orf17; DCNL2"
                     /coded_by="XM_017020647.2:62..796"
                     /db_xref="GeneID:55208"
                     /db_xref="HGNC:HGNC:20328"
ORIGIN      
        1 mactqagert aiycltqnew rldeatdsff qnpdslhres mrnavdkkkl erlygrykdp
       61 qdenkigvdg iqqfcddlsl dpasisvlvi awkfraatqc efsrkefldg mtelgcdsme
      121 klkallprle qelkdtakfk dfyqftftfa knpgqkgldl emavaywklv lsgrfkfldl
      181 wntflmehhk rsiprdtwnl lldfgnmiad dmsnydeega wpvliddfve yarpvvtggk
      241 rslf
//
LOCUS       XP_016876138             134 aa            linear   PRI 05-AUG-2025
DEFINITION  DCN1-like protein 2 isoform X3 [Homo sapiens].
ACCESSION   XP_016876138
VERSION     XP_016876138.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020649.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XP_016876138.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..134
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..134
                     /product="DCN1-like protein 2 isoform X3"
                     /calculated_mol_wt=15538
     Region          11..121
                     /region_name="Cullin_binding"
                     /note="Cullin binding; pfam03556"
                     /db_xref="CDD:460971"
     CDS             1..134
                     /gene="DCUN1D2"
                     /gene_synonym="C13orf17; DCNL2"
                     /coded_by="XM_017020649.2:201..605"
                     /db_xref="GeneID:55208"
                     /db_xref="HGNC:HGNC:20328"
ORIGIN      
        1 mtelgcdsme klkallprle qelkdtakfk dfyqftftfa knpgqkgldl emavaywklv
       61 lsgrfkfldl wntflmehhk rsiprdtwnl lldfgnmiad dmsnydeega wpvliddfve
      121 yarpvvtggk rslf
//
LOCUS       XP_011533436             531 aa            linear   PRI 05-AUG-2025
DEFINITION  RCC1 and BTB domain-containing protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_011533436
VERSION     XP_011533436.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535134.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..531
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..531
                     /product="RCC1 and BTB domain-containing protein 1 isoform
                     X1"
                     /calculated_mol_wt=58121
     Region          13..311
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          350..466
                     /region_name="BTB_POZ_RCBTB1_CLLD7"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in RCC1 and BTB
                     domain-containing protein 1 (RCBTB1); cd18353"
                     /db_xref="CDD:349662"
     Region          466..531
                     /region_name="BACK_RCBTB1"
                     /note="BACK (BTB and C-terminal Kelch) domain found in
                     RCC1 and BTB domain-containing protein 1 (RCBTB1);
                     cd18528"
                     /db_xref="CDD:350603"
     CDS             1..531
                     /gene="RCBTB1"
                     /gene_synonym="CLLD7; CLLL7; GLP; RDEOA"
                     /coded_by="XM_011535134.2:236..1831"
                     /db_xref="GeneID:55213"
                     /db_xref="HGNC:HGNC:18243"
                     /db_xref="MIM:607867"
ORIGIN      
        1 mvdvgkwpif tllspqeias irkacvfgts asealyvtdn devfvfglny snclgtgdnq
       61 stlvpkkleg lcgkkiksls ygsgphvlls tedgvvyawg hngysqlgng ttnqgiapvq
      121 vctnllikqv vevacgshhs malaadgevf awgynncgqv gsgstanqpt prkvtnclhi
      181 krvvgiacgq tssmavldng evygwgyngn gqlglgnngn qltpvrvaal hsvcvnqivc
      241 gyahtlaltd egllyawgan tygqlgtgnk nnllspahim vekervveia achsahtsaa
      301 ktqgghvymw gqcrgqsvil phlthfsctd dvfacfatpa vswrllsveh edfltvaesl
      361 kkefdspeta dlkfridgky ihvhkavlki rcehfrsmfq sywnedmkev ieidqfsypv
      421 yraflqylyt dtvdlppeda iglldlatsy cenrlkklcq hiikrgitve nafslfsaav
      481 rydaedleef cfkfcinhlt evtqtaafwq mdgpllkefi akaskcgafk n
//
LOCUS       XP_011533437             402 aa            linear   PRI 05-AUG-2025
DEFINITION  RCC1 and BTB domain-containing protein 1 isoform X2 [Homo sapiens].
ACCESSION   XP_011533437
VERSION     XP_011533437.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535135.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..402
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..402
                     /product="RCC1 and BTB domain-containing protein 1 isoform
                     X2"
                     /calculated_mol_wt=44284
     Region          <4..>183
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          221..337
                     /region_name="BTB_POZ_RCBTB1_CLLD7"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in RCC1 and BTB
                     domain-containing protein 1 (RCBTB1); cd18353"
                     /db_xref="CDD:349662"
     Region          337..402
                     /region_name="BACK_RCBTB1"
                     /note="BACK (BTB and C-terminal Kelch) domain found in
                     RCC1 and BTB domain-containing protein 1 (RCBTB1);
                     cd18528"
                     /db_xref="CDD:350603"
     CDS             1..402
                     /gene="RCBTB1"
                     /gene_synonym="CLLD7; CLLL7; GLP; RDEOA"
                     /coded_by="XM_011535135.3:160..1368"
                     /db_xref="GeneID:55213"
                     /db_xref="HGNC:HGNC:18243"
                     /db_xref="MIM:607867"
ORIGIN      
        1 messglhvat assgsaghqv fawgynncgq vgsgstanqp tprkvtnclh ikrvvgiacg
       61 qtssmavldn gevygwgyng ngqlglgnng nqltpvrvaa lhsvcvnqiv cgyahtlalt
      121 degllyawga ntygqlgtgn knnllspahi mvekervvei aachsahtsa aktqgghvym
      181 wgqcrgqsvi lphlthfsct ddvfacfatp avswrllsve hedfltvaes lkkefdspet
      241 adlkfridgk yihvhkavlk ircehfrsmf qsywnedmke vieidqfsyp vyraflqyly
      301 tdtvdlpped aiglldlats ycenrlkklc qhiikrgitv enafslfsaa vrydaedlee
      361 fcfkfcinhl tevtqtaafw qmdgpllkef iakaskcgaf kn
//
LOCUS       XP_047286389             309 aa            linear   PRI 05-AUG-2025
DEFINITION  RCC1 and BTB domain-containing protein 1 isoform X3 [Homo sapiens].
ACCESSION   XP_047286389
VERSION     XP_047286389.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430433.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..309
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..309
                     /product="RCC1 and BTB domain-containing protein 1 isoform
                     X3"
                     /calculated_mol_wt=32603
     Region          13..277
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     CDS             1..309
                     /gene="RCBTB1"
                     /gene_synonym="CLLD7; CLLL7; GLP; RDEOA"
                     /coded_by="XM_047430433.1:237..1166"
                     /db_xref="GeneID:55213"
                     /db_xref="HGNC:HGNC:18243"
                     /db_xref="MIM:607867"
ORIGIN      
        1 mvdvgkwpif tllspqeias irkacvfgts asealyvtdn devfvfglny snclgtgdnq
       61 stlvpkkleg lcgkkiksls ygsgphvlls tedgvvyawg hngysqlgng ttnqgiapvq
      121 vctnllikqv vevacgshhs malaadgevf awgynncgqv gsgstanqpt prkvtnclhi
      181 krvvgiacgq tssmavldng evygwgyngn gqlglgnngn qltpvrvaal hsvcvnqivc
      241 gyahtlaltd egllyawgan tygqlgtgnk nnllspahim vekervsvtq tgvqwhdlgs
      301 lqpslrgfk
//
LOCUS       XP_047286390             309 aa            linear   PRI 05-AUG-2025
DEFINITION  RCC1 and BTB domain-containing protein 1 isoform X3 [Homo sapiens].
ACCESSION   XP_047286390
VERSION     XP_047286390.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430434.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..309
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..309
                     /product="RCC1 and BTB domain-containing protein 1 isoform
                     X3"
                     /calculated_mol_wt=32603
     Region          13..277
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     CDS             1..309
                     /gene="RCBTB1"
                     /gene_synonym="CLLD7; CLLL7; GLP; RDEOA"
                     /coded_by="XM_047430434.1:240..1169"
                     /db_xref="GeneID:55213"
                     /db_xref="HGNC:HGNC:18243"
                     /db_xref="MIM:607867"
ORIGIN      
        1 mvdvgkwpif tllspqeias irkacvfgts asealyvtdn devfvfglny snclgtgdnq
       61 stlvpkkleg lcgkkiksls ygsgphvlls tedgvvyawg hngysqlgng ttnqgiapvq
      121 vctnllikqv vevacgshhs malaadgevf awgynncgqv gsgstanqpt prkvtnclhi
      181 krvvgiacgq tssmavldng evygwgyngn gqlglgnngn qltpvrvaal hsvcvnqivc
      241 gyahtlaltd egllyawgan tygqlgtgnk nnllspahim vekervsvtq tgvqwhdlgs
      301 lqpslrgfk
//
LOCUS       XP_011533438             288 aa            linear   PRI 05-AUG-2025
DEFINITION  RCC1 and BTB domain-containing protein 1 isoform X4 [Homo sapiens].
ACCESSION   XP_011533438
VERSION     XP_011533438.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535136.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..288
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..288
                     /product="RCC1 and BTB domain-containing protein 1 isoform
                     X4"
                     /calculated_mol_wt=30244
     Region          13..277
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     CDS             1..288
                     /gene="RCBTB1"
                     /gene_synonym="CLLD7; CLLL7; GLP; RDEOA"
                     /coded_by="XM_011535136.3:237..1103"
                     /db_xref="GeneID:55213"
                     /db_xref="HGNC:HGNC:18243"
                     /db_xref="MIM:607867"
ORIGIN      
        1 mvdvgkwpif tllspqeias irkacvfgts asealyvtdn devfvfglny snclgtgdnq
       61 stlvpkkleg lcgkkiksls ygsgphvlls tedgvvyawg hngysqlgng ttnqgiapvq
      121 vctnllikqv vevacgshhs malaadgevf awgynncgqv gsgstanqpt prkvtnclhi
      181 krvvgiacgq tssmavldng evygwgyngn gqlglgnngn qltpvrvaal hsvcvnqivc
      241 gyahtlaltd egllyawgan tygqlgtgnk nnllspahim vekesadf
//
LOCUS       XP_011533440             447 aa            linear   PRI 05-AUG-2025
DEFINITION  paraspeckle component 1 isoform X1 [Homo sapiens].
ACCESSION   XP_011533440
VERSION     XP_011533440.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535138.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..447
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..447
                     /product="paraspeckle component 1 isoform X1"
                     /calculated_mol_wt=51491
     Region          81..151
                     /region_name="RRM1_PSP1"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     paraspeckle protein 1 (PSP1); cd12586"
                     /db_xref="CDD:409999"
     Site            order(81,128,131..132,135..136,138)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:409999"
     Region          157..236
                     /region_name="RRM2_PSP1"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     paraspeckle protein 1 (PSP1 or PSPC1); cd12589"
                     /db_xref="CDD:410002"
     Site            order(162,165..171,175,178..179,184,186..191,196,200,
                     215..222,224..229,231)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:410002"
     Region          227..319
                     /region_name="NOPS_p54nrb_PSF_PSPC1"
                     /note="NOPS domain, including C-terminal coiled-coil
                     region, in p54nrb/PSF/PSPC1 family proteins; cd12946"
                     /db_xref="CDD:240581"
     Site            order(227..229,231,271..272,274..276,278..280,282..283,
                     285..286,289..290,293..294,296..297,300..301,304..305,
                     307..308,311..312,315)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:240581"
     CDS             1..447
                     /gene="PSPC1"
                     /gene_synonym="PSP1"
                     /coded_by="XM_011535138.4:189..1532"
                     /db_xref="GeneID:55269"
                     /db_xref="HGNC:HGNC:20320"
                     /db_xref="MIM:612408"
ORIGIN      
        1 mmlrgnlkqv rieknparlr alesavgese paaaaamala lagepappap appedhpdee
       61 mgftidiksf lkpgektytq rcrlfvgnlp tditeedfkr lferygepse vfinrdrgfg
      121 firlesrtla eiakaeldgt ilksrplrir fathgaaltv knlspvvsne lleqafsqfg
      181 pvekavvvvd drgratgkgf vefaakppar kalercgdga flltttprpv ivepmeqfdd
      241 edglpeklmq ktqqyhkere qpprfaqpgt fefeyasrwk aldemekqqr eqvdrnirea
      301 kekleaemea arhehqlmlm rqdlmrrqee lrrleelrnq elqkrkqiql rheeehrrre
      361 eemirhreqe elrrqqegfk pnymenyvch flitgytsns evvfpseefm pngaaeeril
      421 tevghqtssl irlstcfppa fkqmist
//
LOCUS       XP_011533441             417 aa            linear   PRI 05-AUG-2025
DEFINITION  paraspeckle component 1 isoform X2 [Homo sapiens].
ACCESSION   XP_011533441
VERSION     XP_011533441.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535139.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..417
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..417
                     /product="paraspeckle component 1 isoform X2"
                     /calculated_mol_wt=48231
     Region          81..151
                     /region_name="RRM1_PSP1"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     paraspeckle protein 1 (PSP1); cd12586"
                     /db_xref="CDD:409999"
     Site            order(81,128,131..132,135..136,138)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:409999"
     Region          157..236
                     /region_name="RRM2_PSP1"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     paraspeckle protein 1 (PSP1 or PSPC1); cd12589"
                     /db_xref="CDD:410002"
     Site            order(162,165..171,175,178..179,184,186..191,196,200,
                     215..222,224..229,231)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:410002"
     Region          227..319
                     /region_name="NOPS_p54nrb_PSF_PSPC1"
                     /note="NOPS domain, including C-terminal coiled-coil
                     region, in p54nrb/PSF/PSPC1 family proteins; cd12946"
                     /db_xref="CDD:240581"
     Site            order(227..229,231,271..272,274..276,278..280,282..283,
                     285..286,289..290,293..294,296..297,300..301,304..305,
                     307..308,311..312,315)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:240581"
     CDS             1..417
                     /gene="PSPC1"
                     /gene_synonym="PSP1"
                     /coded_by="XM_011535139.3:189..1442"
                     /db_xref="GeneID:55269"
                     /db_xref="HGNC:HGNC:20320"
                     /db_xref="MIM:612408"
ORIGIN      
        1 mmlrgnlkqv rieknparlr alesavgese paaaaamala lagepappap appedhpdee
       61 mgftidiksf lkpgektytq rcrlfvgnlp tditeedfkr lferygepse vfinrdrgfg
      121 firlesrtla eiakaeldgt ilksrplrir fathgaaltv knlspvvsne lleqafsqfg
      181 pvekavvvvd drgratgkgf vefaakppar kalercgdga flltttprpv ivepmeqfdd
      241 edglpeklmq ktqqyhkere qpprfaqpgt fefeyasrwk aldemekqqr eqvdrnirea
      301 kekleaemea arhehqlmlm rqdlmrrqee lrrleelrnq elqkrkqiql rheeehrrre
      361 eemirhreqe elrrqqegfk pnymenvylm sfhlkwvike nvaevtrssa csviqks
//
LOCUS       XP_047286391             417 aa            linear   PRI 05-AUG-2025
DEFINITION  paraspeckle component 1 isoform X2 [Homo sapiens].
ACCESSION   XP_047286391
VERSION     XP_047286391.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430435.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..417
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..417
                     /product="paraspeckle component 1 isoform X2"
                     /calculated_mol_wt=48231
     Region          81..151
                     /region_name="RRM1_PSP1"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     paraspeckle protein 1 (PSP1); cd12586"
                     /db_xref="CDD:409999"
     Site            order(81,128,131..132,135..136,138)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:409999"
     Region          157..236
                     /region_name="RRM2_PSP1"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     paraspeckle protein 1 (PSP1 or PSPC1); cd12589"
                     /db_xref="CDD:410002"
     Site            order(162,165..171,175,178..179,184,186..191,196,200,
                     215..222,224..229,231)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:410002"
     Region          227..319
                     /region_name="NOPS_p54nrb_PSF_PSPC1"
                     /note="NOPS domain, including C-terminal coiled-coil
                     region, in p54nrb/PSF/PSPC1 family proteins; cd12946"
                     /db_xref="CDD:240581"
     Site            order(227..229,231,271..272,274..276,278..280,282..283,
                     285..286,289..290,293..294,296..297,300..301,304..305,
                     307..308,311..312,315)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:240581"
     CDS             1..417
                     /gene="PSPC1"
                     /gene_synonym="PSP1"
                     /coded_by="XM_047430435.1:189..1442"
                     /db_xref="GeneID:55269"
                     /db_xref="HGNC:HGNC:20320"
                     /db_xref="MIM:612408"
ORIGIN      
        1 mmlrgnlkqv rieknparlr alesavgese paaaaamala lagepappap appedhpdee
       61 mgftidiksf lkpgektytq rcrlfvgnlp tditeedfkr lferygepse vfinrdrgfg
      121 firlesrtla eiakaeldgt ilksrplrir fathgaaltv knlspvvsne lleqafsqfg
      181 pvekavvvvd drgratgkgf vefaakppar kalercgdga flltttprpv ivepmeqfdd
      241 edglpeklmq ktqqyhkere qpprfaqpgt fefeyasrwk aldemekqqr eqvdrnirea
      301 kekleaemea arhehqlmlm rqdlmrrqee lrrleelrnq elqkrkqiql rheeehrrre
      361 eemirhreqe elrrqqegfk pnymenvylm sfhlkwvike nvaevtrssa csviqks
//
LOCUS       XP_011533443             409 aa            linear   PRI 05-AUG-2025
DEFINITION  paraspeckle component 1 isoform X3 [Homo sapiens].
ACCESSION   XP_011533443
VERSION     XP_011533443.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535141.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..409
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..409
                     /product="paraspeckle component 1 isoform X3"
                     /calculated_mol_wt=47334
     Region          81..151
                     /region_name="RRM1_PSP1"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     paraspeckle protein 1 (PSP1); cd12586"
                     /db_xref="CDD:409999"
     Site            order(81,128,131..132,135..136,138)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:409999"
     Region          157..236
                     /region_name="RRM2_PSP1"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     paraspeckle protein 1 (PSP1 or PSPC1); cd12589"
                     /db_xref="CDD:410002"
     Site            order(162,165..171,175,178..179,184,186..191,196,200,
                     215..222,224..229,231)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:410002"
     Region          227..319
                     /region_name="NOPS_p54nrb_PSF_PSPC1"
                     /note="NOPS domain, including C-terminal coiled-coil
                     region, in p54nrb/PSF/PSPC1 family proteins; cd12946"
                     /db_xref="CDD:240581"
     Site            order(227..229,231,271..272,274..276,278..280,282..283,
                     285..286,289..290,293..294,296..297,300..301,304..305,
                     307..308,311..312,315)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:240581"
     CDS             1..409
                     /gene="PSPC1"
                     /gene_synonym="PSP1"
                     /coded_by="XM_011535141.4:189..1418"
                     /db_xref="GeneID:55269"
                     /db_xref="HGNC:HGNC:20320"
                     /db_xref="MIM:612408"
ORIGIN      
        1 mmlrgnlkqv rieknparlr alesavgese paaaaamala lagepappap appedhpdee
       61 mgftidiksf lkpgektytq rcrlfvgnlp tditeedfkr lferygepse vfinrdrgfg
      121 firlesrtla eiakaeldgt ilksrplrir fathgaaltv knlspvvsne lleqafsqfg
      181 pvekavvvvd drgratgkgf vefaakppar kalercgdga flltttprpv ivepmeqfdd
      241 edglpeklmq ktqqyhkere qpprfaqpgt fefeyasrwk aldemekqqr eqvdrnirea
      301 kekleaemea arhehqlmlm rqdlmrrqee lrrleelrnq elqkrkqiql rheeehrrre
      361 eemirhreqe elrrqqegfk pnymenfkgr nqmvsvqlvq vmskvdflc
//
LOCUS       XP_011533444             406 aa            linear   PRI 05-AUG-2025
DEFINITION  paraspeckle component 1 isoform X4 [Homo sapiens].
ACCESSION   XP_011533444
VERSION     XP_011533444.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535142.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..406
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..406
                     /product="paraspeckle component 1 isoform X4"
                     /calculated_mol_wt=46810
     Region          81..151
                     /region_name="RRM1_PSP1"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     paraspeckle protein 1 (PSP1); cd12586"
                     /db_xref="CDD:409999"
     Site            order(81,128,131..132,135..136,138)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:409999"
     Region          157..236
                     /region_name="RRM2_PSP1"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     paraspeckle protein 1 (PSP1 or PSPC1); cd12589"
                     /db_xref="CDD:410002"
     Site            order(162,165..171,175,178..179,184,186..191,196,200,
                     215..222,224..229,231)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:410002"
     Region          227..319
                     /region_name="NOPS_p54nrb_PSF_PSPC1"
                     /note="NOPS domain, including C-terminal coiled-coil
                     region, in p54nrb/PSF/PSPC1 family proteins; cd12946"
                     /db_xref="CDD:240581"
     Site            order(227..229,231,271..272,274..276,278..280,282..283,
                     285..286,289..290,293..294,296..297,300..301,304..305,
                     307..308,311..312,315)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:240581"
     CDS             1..406
                     /gene="PSPC1"
                     /gene_synonym="PSP1"
                     /coded_by="XM_011535142.4:189..1409"
                     /db_xref="GeneID:55269"
                     /db_xref="HGNC:HGNC:20320"
                     /db_xref="MIM:612408"
ORIGIN      
        1 mmlrgnlkqv rieknparlr alesavgese paaaaamala lagepappap appedhpdee
       61 mgftidiksf lkpgektytq rcrlfvgnlp tditeedfkr lferygepse vfinrdrgfg
      121 firlesrtla eiakaeldgt ilksrplrir fathgaaltv knlspvvsne lleqafsqfg
      181 pvekavvvvd drgratgkgf vefaakppar kalercgdga flltttprpv ivepmeqfdd
      241 edglpeklmq ktqqyhkere qpprfaqpgt fefeyasrwk aldemekqqr eqvdrnirea
      301 kekleaemea arhehqlmlm rqdlmrrqee lrrleelrnq elqkrkqiql rheeehrrre
      361 eemirhreqe elrrqqegfk pnymenrwgl dmlprlgsss plssss
//
LOCUS       XP_047286392             340 aa            linear   PRI 05-AUG-2025
DEFINITION  GPALPP motifs-containing protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047286392
VERSION     XP_047286392.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430436.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..340
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..340
                     /product="GPALPP motifs-containing protein 1 isoform X1"
                     /calculated_mol_wt=38011
     Region          196..332
                     /region_name="DUF3752"
                     /note="Protein of unknown function (DUF3752); pfam12572"
                     /db_xref="CDD:463632"
     CDS             1..340
                     /gene="GPALPP1"
                     /gene_synonym="AD029; bA245H20.2; KIAA1704; LSR7"
                     /coded_by="XM_047430436.1:118..1140"
                     /db_xref="GeneID:55425"
                     /db_xref="HGNC:HGNC:20298"
ORIGIN      
        1 mardligpal ppgfkargta edeerdpspv agpalppnyk ssssdssdsd edssslyeeg
       61 nqeseeddsg ptarkqrknq ddddddddgf fgpalppgfk kqddspprpi igpalppgfi
      121 kstqksdkgr ddpgqqetds sedediigpm pakgpvnynv ttefekraqr mkekltkgdd
      181 dsskpivres wmtelppemk dfglgprtfk rraddtsgdr siwtdtpadr erkaketqea
      241 rkssskkdee hilsgrdkrl aeqvssynes krseslmdih hkklkskaae dknkpqerip
      301 fdrdkdlkvn rfdeaqkkal ikksrelntr fshgkgnmfl
//
LOCUS       XP_005266501             340 aa            linear   PRI 05-AUG-2025
DEFINITION  GPALPP motifs-containing protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_005266501
VERSION     XP_005266501.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266444.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..340
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..340
                     /product="GPALPP motifs-containing protein 1 isoform X1"
                     /calculated_mol_wt=38011
     Region          196..332
                     /region_name="DUF3752"
                     /note="Protein of unknown function (DUF3752); pfam12572"
                     /db_xref="CDD:463632"
     CDS             1..340
                     /gene="GPALPP1"
                     /gene_synonym="AD029; bA245H20.2; KIAA1704; LSR7"
                     /coded_by="XM_005266444.4:118..1140"
                     /db_xref="GeneID:55425"
                     /db_xref="HGNC:HGNC:20298"
ORIGIN      
        1 mardligpal ppgfkargta edeerdpspv agpalppnyk ssssdssdsd edssslyeeg
       61 nqeseeddsg ptarkqrknq ddddddddgf fgpalppgfk kqddspprpi igpalppgfi
      121 kstqksdkgr ddpgqqetds sedediigpm pakgpvnynv ttefekraqr mkekltkgdd
      181 dsskpivres wmtelppemk dfglgprtfk rraddtsgdr siwtdtpadr erkaketqea
      241 rkssskkdee hilsgrdkrl aeqvssynes krseslmdih hkklkskaae dknkpqerip
      301 fdrdkdlkvn rfdeaqkkal ikksrelntr fshgkgnmfl
//
LOCUS       XP_011533446             217 aa            linear   PRI 05-AUG-2025
DEFINITION  GPALPP motifs-containing protein 1 isoform X2 [Homo sapiens].
ACCESSION   XP_011533446
VERSION     XP_011533446.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535144.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..217
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..217
                     /product="GPALPP motifs-containing protein 1 isoform X2"
                     /calculated_mol_wt=24828
     Region          73..209
                     /region_name="DUF3752"
                     /note="Protein of unknown function (DUF3752); pfam12572"
                     /db_xref="CDD:463632"
     CDS             1..217
                     /gene="GPALPP1"
                     /gene_synonym="AD029; bA245H20.2; KIAA1704; LSR7"
                     /coded_by="XM_011535144.3:168..821"
                     /db_xref="GeneID:55425"
                     /db_xref="HGNC:HGNC:20298"
ORIGIN      
        1 mhavttttgl ncnetdssed ediigpmpak gpvnynvtte fekraqrmke kltkgdddss
       61 kpivreswmt elppemkdfg lgprtfkrra ddtsgdrsiw tdtpadrerk aketqearks
      121 sskkdeehil sgrdkrlaeq vssyneskrs eslmdihhkk lkskaaedkn kpqeripfdr
      181 dkdlkvnrfd eaqkkalikk srelntrfsh gkgnmfl
//
LOCUS       XP_047286393             191 aa            linear   PRI 05-AUG-2025
DEFINITION  GPALPP motifs-containing protein 1 isoform X3 [Homo sapiens].
ACCESSION   XP_047286393
VERSION     XP_047286393.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430437.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..191
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..191
                     /product="GPALPP motifs-containing protein 1 isoform X3"
                     /calculated_mol_wt=22095
     Region          47..183
                     /region_name="DUF3752"
                     /note="Protein of unknown function (DUF3752); pfam12572"
                     /db_xref="CDD:463632"
     CDS             1..191
                     /gene="GPALPP1"
                     /gene_synonym="AD029; bA245H20.2; KIAA1704; LSR7"
                     /coded_by="XM_047430437.1:130..705"
                     /db_xref="GeneID:55425"
                     /db_xref="HGNC:HGNC:20298"
ORIGIN      
        1 mpakgpvnyn vttefekraq rmkekltkgd ddsskpivre swmtelppem kdfglgprtf
       61 krraddtsgd rsiwtdtpad rerkaketqe arkssskkde ehilsgrdkr laeqvssyne
      121 skrseslmdi hhkklkskaa edknkpqeri pfdrdkdlkv nrfdeaqkka likksrelnt
      181 rfshgkgnmf l
//
LOCUS       XP_047286394             166 aa            linear   PRI 05-AUG-2025
DEFINITION  GPALPP motifs-containing protein 1 isoform X4 [Homo sapiens].
ACCESSION   XP_047286394
VERSION     XP_047286394.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430438.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..166
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..166
                     /product="GPALPP motifs-containing protein 1 isoform X4"
                     /calculated_mol_wt=17967
     CDS             1..166
                     /gene="GPALPP1"
                     /gene_synonym="AD029; bA245H20.2; KIAA1704; LSR7"
                     /coded_by="XM_047430438.1:118..618"
                     /db_xref="GeneID:55425"
                     /db_xref="HGNC:HGNC:20298"
ORIGIN      
        1 mardligpal ppgfkargta edeerdpspv agpalppnyk ssssdssdsd edssslyeeg
       61 nqeseeddsg ptarkqrknq ddddddddgf fgpalppgfk kqddspprpi igpalppgfi
      121 kstqksdkgr ddpgqqvmsc fkrkqtavkm rilldqclqk dqltim
//
LOCUS       XP_047286396             417 aa            linear   PRI 05-AUG-2025
DEFINITION  tumor necrosis factor receptor superfamily member 19 isoform X1
            [Homo sapiens].
ACCESSION   XP_047286396
VERSION     XP_047286396.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430440.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..417
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..417
                     /product="tumor necrosis factor receptor superfamily
                     member 19 isoform X1"
                     /calculated_mol_wt=45174
     Region          33..149
                     /region_name="TNFRSF19"
                     /note="Tumor necrosis factor receptor superfamily member
                     19 (TNFRSF19), also known as TROY; cd13418"
                     /db_xref="CDD:276923"
     Region          34..72
                     /region_name="CRD1"
                     /note="CRD1 [structural motif]"
                     /db_xref="CDD:276923"
     Region          75..114
                     /region_name="CRD2"
                     /note="CRD2 [structural motif]"
                     /db_xref="CDD:276923"
     Region          117..149
                     /region_name="CRD3"
                     /note="CRD3 [structural motif]"
                     /db_xref="CDD:276923"
     CDS             1..417
                     /gene="TNFRSF19"
                     /gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
                     /coded_by="XM_047430440.1:562..1815"
                     /db_xref="GeneID:55504"
                     /db_xref="HGNC:HGNC:11915"
                     /db_xref="MIM:606122"
ORIGIN      
        1 malkvlleqe ktfftllvll gylsckvtce sgdcrqqefr drsgncvpcn qcgpgmelsk
       61 ecgfgygeda qcvtcrlhrf kedwgfqkck pcldcavvnr fqkancsats daicgdclpg
      121 fyrktklvgf qdmecvpcgd ppppyephca skvnlvkias tassprdtal aavicsalat
      181 vllallilcv iyckrqfmek kpswslrsqd iqyngselsc fdrpqlheya hraccqcrrd
      241 svqtcgpvrl lpsmcceeac spnpatlgcg vhsaaslqar nagpagemvp tffgsltqsi
      301 cgefsdawpl mqnpmggdni sfcdsypelt gedihslnpe lesstsldsn ssqdlvggav
      361 pvqshsenft aatdlsrynn tlvesastqd altmrsqldq esgavihpat qtslqea
//
LOCUS       XP_047286397             417 aa            linear   PRI 05-AUG-2025
DEFINITION  tumor necrosis factor receptor superfamily member 19 isoform X1
            [Homo sapiens].
ACCESSION   XP_047286397
VERSION     XP_047286397.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430441.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..417
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..417
                     /product="tumor necrosis factor receptor superfamily
                     member 19 isoform X1"
                     /calculated_mol_wt=45174
     Region          33..149
                     /region_name="TNFRSF19"
                     /note="Tumor necrosis factor receptor superfamily member
                     19 (TNFRSF19), also known as TROY; cd13418"
                     /db_xref="CDD:276923"
     Region          34..72
                     /region_name="CRD1"
                     /note="CRD1 [structural motif]"
                     /db_xref="CDD:276923"
     Region          75..114
                     /region_name="CRD2"
                     /note="CRD2 [structural motif]"
                     /db_xref="CDD:276923"
     Region          117..149
                     /region_name="CRD3"
                     /note="CRD3 [structural motif]"
                     /db_xref="CDD:276923"
     CDS             1..417
                     /gene="TNFRSF19"
                     /gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
                     /coded_by="XM_047430441.1:295..1548"
                     /db_xref="GeneID:55504"
                     /db_xref="HGNC:HGNC:11915"
                     /db_xref="MIM:606122"
ORIGIN      
        1 malkvlleqe ktfftllvll gylsckvtce sgdcrqqefr drsgncvpcn qcgpgmelsk
       61 ecgfgygeda qcvtcrlhrf kedwgfqkck pcldcavvnr fqkancsats daicgdclpg
      121 fyrktklvgf qdmecvpcgd ppppyephca skvnlvkias tassprdtal aavicsalat
      181 vllallilcv iyckrqfmek kpswslrsqd iqyngselsc fdrpqlheya hraccqcrrd
      241 svqtcgpvrl lpsmcceeac spnpatlgcg vhsaaslqar nagpagemvp tffgsltqsi
      301 cgefsdawpl mqnpmggdni sfcdsypelt gedihslnpe lesstsldsn ssqdlvggav
      361 pvqshsenft aatdlsrynn tlvesastqd altmrsqldq esgavihpat qtslqea
//
LOCUS       XP_005266503             328 aa            linear   PRI 05-AUG-2025
DEFINITION  tumor necrosis factor receptor superfamily member 19 isoform X2
            [Homo sapiens].
ACCESSION   XP_005266503
VERSION     XP_005266503.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266446.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..328
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..328
                     /product="tumor necrosis factor receptor superfamily
                     member 19 isoform X2"
                     /calculated_mol_wt=35838
     Region          33..149
                     /region_name="TNFRSF19"
                     /note="Tumor necrosis factor receptor superfamily member
                     19 (TNFRSF19), also known as TROY; cd13418"
                     /db_xref="CDD:276923"
     Region          34..72
                     /region_name="CRD1"
                     /note="CRD1 [structural motif]"
                     /db_xref="CDD:276923"
     Region          75..114
                     /region_name="CRD2"
                     /note="CRD2 [structural motif]"
                     /db_xref="CDD:276923"
     Region          117..149
                     /region_name="CRD3"
                     /note="CRD3 [structural motif]"
                     /db_xref="CDD:276923"
     CDS             1..328
                     /gene="TNFRSF19"
                     /gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
                     /coded_by="XM_005266446.3:472..1458"
                     /db_xref="GeneID:55504"
                     /db_xref="HGNC:HGNC:11915"
                     /db_xref="MIM:606122"
ORIGIN      
        1 malkvlleqe ktfftllvll gylsckvtce sgdcrqqefr drsgncvpcn qcgpgmelsk
       61 ecgfgygeda qcvtcrlhrf kedwgfqkck pcldcavvnr fqkancsats daicgdclpg
      121 fyrktklvgf qdmecvpcgd ppppyephca skvnlvkias tassprdtal aavicsalat
      181 vllallilcv iyckrqfmek kpswslrsqd iqyngselsc fdrpqlheya hraccqcrrd
      241 svqtcgpvrl lpsmcceeac spnpatlgcg vhsaaslqar klkepasfcs rsvcwnpkst
      301 pllglwteqs gpcmasgaki nlnqtdgi
//
LOCUS       XP_047286398             328 aa            linear   PRI 05-AUG-2025
DEFINITION  tumor necrosis factor receptor superfamily member 19 isoform X2
            [Homo sapiens].
ACCESSION   XP_047286398
VERSION     XP_047286398.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430442.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..328
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..328
                     /product="tumor necrosis factor receptor superfamily
                     member 19 isoform X2"
                     /calculated_mol_wt=35838
     Region          33..149
                     /region_name="TNFRSF19"
                     /note="Tumor necrosis factor receptor superfamily member
                     19 (TNFRSF19), also known as TROY; cd13418"
                     /db_xref="CDD:276923"
     Region          34..72
                     /region_name="CRD1"
                     /note="CRD1 [structural motif]"
                     /db_xref="CDD:276923"
     Region          75..114
                     /region_name="CRD2"
                     /note="CRD2 [structural motif]"
                     /db_xref="CDD:276923"
     Region          117..149
                     /region_name="CRD3"
                     /note="CRD3 [structural motif]"
                     /db_xref="CDD:276923"
     CDS             1..328
                     /gene="TNFRSF19"
                     /gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
                     /coded_by="XM_047430442.1:562..1548"
                     /db_xref="GeneID:55504"
                     /db_xref="HGNC:HGNC:11915"
                     /db_xref="MIM:606122"
ORIGIN      
        1 malkvlleqe ktfftllvll gylsckvtce sgdcrqqefr drsgncvpcn qcgpgmelsk
       61 ecgfgygeda qcvtcrlhrf kedwgfqkck pcldcavvnr fqkancsats daicgdclpg
      121 fyrktklvgf qdmecvpcgd ppppyephca skvnlvkias tassprdtal aavicsalat
      181 vllallilcv iyckrqfmek kpswslrsqd iqyngselsc fdrpqlheya hraccqcrrd
      241 svqtcgpvrl lpsmcceeac spnpatlgcg vhsaaslqar klkepasfcs rsvcwnpkst
      301 pllglwteqs gpcmasgaki nlnqtdgi
//
LOCUS       XP_047286399             328 aa            linear   PRI 05-AUG-2025
DEFINITION  tumor necrosis factor receptor superfamily member 19 isoform X2
            [Homo sapiens].
ACCESSION   XP_047286399
VERSION     XP_047286399.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430443.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..328
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..328
                     /product="tumor necrosis factor receptor superfamily
                     member 19 isoform X2"
                     /calculated_mol_wt=35838
     Region          33..149
                     /region_name="TNFRSF19"
                     /note="Tumor necrosis factor receptor superfamily member
                     19 (TNFRSF19), also known as TROY; cd13418"
                     /db_xref="CDD:276923"
     Region          34..72
                     /region_name="CRD1"
                     /note="CRD1 [structural motif]"
                     /db_xref="CDD:276923"
     Region          75..114
                     /region_name="CRD2"
                     /note="CRD2 [structural motif]"
                     /db_xref="CDD:276923"
     Region          117..149
                     /region_name="CRD3"
                     /note="CRD3 [structural motif]"
                     /db_xref="CDD:276923"
     CDS             1..328
                     /gene="TNFRSF19"
                     /gene_synonym="TAJ; TAJ-alpha; TRADE; TROY"
                     /coded_by="XM_047430443.1:295..1281"
                     /db_xref="GeneID:55504"
                     /db_xref="HGNC:HGNC:11915"
                     /db_xref="MIM:606122"
ORIGIN      
        1 malkvlleqe ktfftllvll gylsckvtce sgdcrqqefr drsgncvpcn qcgpgmelsk
       61 ecgfgygeda qcvtcrlhrf kedwgfqkck pcldcavvnr fqkancsats daicgdclpg
      121 fyrktklvgf qdmecvpcgd ppppyephca skvnlvkias tassprdtal aavicsalat
      181 vllallilcv iyckrqfmek kpswslrsqd iqyngselsc fdrpqlheya hraccqcrrd
      241 svqtcgpvrl lpsmcceeac spnpatlgcg vhsaaslqar klkepasfcs rsvcwnpkst
      301 pllglwteqs gpcmasgaki nlnqtdgi
//
LOCUS       XP_005266504             859 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor SPT20 homolog isoform X1 [Homo sapiens].
ACCESSION   XP_005266504
VERSION     XP_005266504.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266447.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..859
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..859
                     /product="transcription factor SPT20 homolog isoform X1"
                     /calculated_mol_wt=93854
     Region          77..214
                     /region_name="Spt20"
                     /note="Spt20 family; pfam12090"
                     /db_xref="CDD:463459"
     CDS             1..859
                     /gene="SUPT20H"
                     /gene_synonym="C13; C13orf19; FAM48A; FP757; P38IP; SPT20"
                     /coded_by="XM_005266447.3:224..2803"
                     /db_xref="GeneID:55578"
                     /db_xref="HGNC:HGNC:20596"
                     /db_xref="MIM:613417"
ORIGIN      
        1 mqqalelald raeyviesar qrppkrkyls sgrksvfqkl ydlyieecek epevkqklrr
       61 nvnlleklvm qetlsclvvn lypgnegysl mlrgkngsds etirlpyeeg elleyldaee
      121 lppilvdlle ksqvnifhcg cviaeirdyr qssnmkspgy qsrhillrpt mqtlicdvhs
      181 itsdnhkwtq edklllesql ilataeplcl dpsiavtcta nrllynkqkm ntrpmkrcfk
      241 rysrsslnrq qdlshcpppp qlrlldflqk rkerkagqhy dlkiskagnc vdmwkrspcn
      301 laipsevdve kyakveksik sddsqptvwp ahdvkddyvf eceagtqyqk tkltilqslg
      361 dplyygkiqp ckadeesdsq mspshsstdd hsnwfiigsk tdaervvnqy qelvqneakc
      421 pvkmshsssg saslsqvspg ketdqtetvs vqssvlgkgv khrpppiklp sssgnsssgn
      481 yftpqqtssf lksptpppss kpssiprkss vdlnqvsmls paalspasss qrsgtpkpst
      541 ptptpsstph ppdaqsstps tpsatptpqd sgftpqptll tqfaqqqrsl sqampvttip
      601 lstmvtsitp gttatqvman saglnfinvv gsvcgaqalm sgsnpmlgcn tgaitpagin
      661 lsgllpsggl lpnalpsamq aasqagvpfg lkntsslrpl nllqlpggsl ifntlqqqqq
      721 qlsqftpqqp qqpttcspqq pgeqgseqgs tsqeqalsaq qaavinltgv gsfmqsqaav
      781 lsqlgsaenr peqslpqqrf qlssafqqqq qqiqqlrflq hqmamaaaaa qtaqlhhhrh
      841 tgsqskskmk rgtpttpkf
//
LOCUS       XP_005266506             859 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor SPT20 homolog isoform X1 [Homo sapiens].
ACCESSION   XP_005266506
VERSION     XP_005266506.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266449.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..859
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..859
                     /product="transcription factor SPT20 homolog isoform X1"
                     /calculated_mol_wt=93854
     Region          77..214
                     /region_name="Spt20"
                     /note="Spt20 family; pfam12090"
                     /db_xref="CDD:463459"
     CDS             1..859
                     /gene="SUPT20H"
                     /gene_synonym="C13; C13orf19; FAM48A; FP757; P38IP; SPT20"
                     /coded_by="XM_005266449.5:303..2882"
                     /db_xref="GeneID:55578"
                     /db_xref="HGNC:HGNC:20596"
                     /db_xref="MIM:613417"
ORIGIN      
        1 mqqalelald raeyviesar qrppkrkyls sgrksvfqkl ydlyieecek epevkqklrr
       61 nvnlleklvm qetlsclvvn lypgnegysl mlrgkngsds etirlpyeeg elleyldaee
      121 lppilvdlle ksqvnifhcg cviaeirdyr qssnmkspgy qsrhillrpt mqtlicdvhs
      181 itsdnhkwtq edklllesql ilataeplcl dpsiavtcta nrllynkqkm ntrpmkrcfk
      241 rysrsslnrq qdlshcpppp qlrlldflqk rkerkagqhy dlkiskagnc vdmwkrspcn
      301 laipsevdve kyakveksik sddsqptvwp ahdvkddyvf eceagtqyqk tkltilqslg
      361 dplyygkiqp ckadeesdsq mspshsstdd hsnwfiigsk tdaervvnqy qelvqneakc
      421 pvkmshsssg saslsqvspg ketdqtetvs vqssvlgkgv khrpppiklp sssgnsssgn
      481 yftpqqtssf lksptpppss kpssiprkss vdlnqvsmls paalspasss qrsgtpkpst
      541 ptptpsstph ppdaqsstps tpsatptpqd sgftpqptll tqfaqqqrsl sqampvttip
      601 lstmvtsitp gttatqvman saglnfinvv gsvcgaqalm sgsnpmlgcn tgaitpagin
      661 lsgllpsggl lpnalpsamq aasqagvpfg lkntsslrpl nllqlpggsl ifntlqqqqq
      721 qlsqftpqqp qqpttcspqq pgeqgseqgs tsqeqalsaq qaavinltgv gsfmqsqaav
      781 lsqlgsaenr peqslpqqrf qlssafqqqq qqiqqlrflq hqmamaaaaa qtaqlhhhrh
      841 tgsqskskmk rgtpttpkf
//
LOCUS       XP_005266508             858 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor SPT20 homolog isoform X2 [Homo sapiens].
ACCESSION   XP_005266508
VERSION     XP_005266508.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266451.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..858
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..858
                     /product="transcription factor SPT20 homolog isoform X2"
                     /calculated_mol_wt=93726
     Region          76..213
                     /region_name="Spt20"
                     /note="Spt20 family; pfam12090"
                     /db_xref="CDD:463459"
     CDS             1..858
                     /gene="SUPT20H"
                     /gene_synonym="C13; C13orf19; FAM48A; FP757; P38IP; SPT20"
                     /coded_by="XM_005266451.5:224..2800"
                     /db_xref="GeneID:55578"
                     /db_xref="HGNC:HGNC:20596"
                     /db_xref="MIM:613417"
ORIGIN      
        1 mqqalelald raeyviesar qrppkrkyls sgrksvfqkl ydlyieecek epevkklrrn
       61 vnlleklvmq etlsclvvnl ypgnegyslm lrgkngsdse tirlpyeege lleyldaeel
      121 ppilvdllek sqvnifhcgc viaeirdyrq ssnmkspgyq srhillrptm qtlicdvhsi
      181 tsdnhkwtqe dklllesqli lataeplcld psiavtctan rllynkqkmn trpmkrcfkr
      241 ysrsslnrqq dlshcppppq lrlldflqkr kerkagqhyd lkiskagncv dmwkrspcnl
      301 aipsevdvek yakveksiks ddsqptvwpa hdvkddyvfe ceagtqyqkt kltilqslgd
      361 plyygkiqpc kadeesdsqm spshsstddh snwfiigskt daervvnqyq elvqneakcp
      421 vkmshsssgs aslsqvspgk etdqtetvsv qssvlgkgvk hrpppiklps ssgnsssgny
      481 ftpqqtssfl ksptpppssk pssiprkssv dlnqvsmlsp aalspasssq rsgtpkpstp
      541 tptpsstphp pdaqsstpst psatptpqds gftpqptllt qfaqqqrsls qampvttipl
      601 stmvtsitpg ttatqvmans aglnfinvvg svcgaqalms gsnpmlgcnt gaitpaginl
      661 sgllpsggll pnalpsamqa asqagvpfgl kntsslrpln llqlpggsli fntlqqqqqq
      721 lsqftpqqpq qpttcspqqp geqgseqgst sqeqalsaqq aavinltgvg sfmqsqaavl
      781 sqlgsaenrp eqslpqqrfq lssafqqqqq qiqqlrflqh qmamaaaaaq taqlhhhrht
      841 gsqskskmkr gtpttpkf
//
LOCUS       XP_047286400             858 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor SPT20 homolog isoform X2 [Homo sapiens].
ACCESSION   XP_047286400
VERSION     XP_047286400.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430444.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..858
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..858
                     /product="transcription factor SPT20 homolog isoform X2"
                     /calculated_mol_wt=93726
     Region          76..213
                     /region_name="Spt20"
                     /note="Spt20 family; pfam12090"
                     /db_xref="CDD:463459"
     CDS             1..858
                     /gene="SUPT20H"
                     /gene_synonym="C13; C13orf19; FAM48A; FP757; P38IP; SPT20"
                     /coded_by="XM_047430444.1:303..2879"
                     /db_xref="GeneID:55578"
                     /db_xref="HGNC:HGNC:20596"
                     /db_xref="MIM:613417"
ORIGIN      
        1 mqqalelald raeyviesar qrppkrkyls sgrksvfqkl ydlyieecek epevkklrrn
       61 vnlleklvmq etlsclvvnl ypgnegyslm lrgkngsdse tirlpyeege lleyldaeel
      121 ppilvdllek sqvnifhcgc viaeirdyrq ssnmkspgyq srhillrptm qtlicdvhsi
      181 tsdnhkwtqe dklllesqli lataeplcld psiavtctan rllynkqkmn trpmkrcfkr
      241 ysrsslnrqq dlshcppppq lrlldflqkr kerkagqhyd lkiskagncv dmwkrspcnl
      301 aipsevdvek yakveksiks ddsqptvwpa hdvkddyvfe ceagtqyqkt kltilqslgd
      361 plyygkiqpc kadeesdsqm spshsstddh snwfiigskt daervvnqyq elvqneakcp
      421 vkmshsssgs aslsqvspgk etdqtetvsv qssvlgkgvk hrpppiklps ssgnsssgny
      481 ftpqqtssfl ksptpppssk pssiprkssv dlnqvsmlsp aalspasssq rsgtpkpstp
      541 tptpsstphp pdaqsstpst psatptpqds gftpqptllt qfaqqqrsls qampvttipl
      601 stmvtsitpg ttatqvmans aglnfinvvg svcgaqalms gsnpmlgcnt gaitpaginl
      661 sgllpsggll pnalpsamqa asqagvpfgl kntsslrpln llqlpggsli fntlqqqqqq
      721 lsqftpqqpq qpttcspqqp geqgseqgst sqeqalsaqq aavinltgvg sfmqsqaavl
      781 sqlgsaenrp eqslpqqrfq lssafqqqqq qiqqlrflqh qmamaaaaaq taqlhhhrht
      841 gsqskskmkr gtpttpkf
//
LOCUS       XP_005266511             847 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor SPT20 homolog isoform X3 [Homo sapiens].
ACCESSION   XP_005266511
VERSION     XP_005266511.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266454.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..847
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..847
                     /product="transcription factor SPT20 homolog isoform X3"
                     /calculated_mol_wt=92516
     Region          65..202
                     /region_name="Spt20"
                     /note="Spt20 family; pfam12090"
                     /db_xref="CDD:463459"
     CDS             1..847
                     /gene="SUPT20H"
                     /gene_synonym="C13; C13orf19; FAM48A; FP757; P38IP; SPT20"
                     /coded_by="XM_005266454.5:224..2767"
                     /db_xref="GeneID:55578"
                     /db_xref="HGNC:HGNC:20596"
                     /db_xref="MIM:613417"
ORIGIN      
        1 myviesarqr ppkrkylssg rksvfqklyd lyieecekep evkqklrrnv nlleklvmqe
       61 tlsclvvnly pgnegyslml rgkngsdset irlpyeegel leyldaeelp pilvdlleks
      121 qvnifhcgcv iaeirdyrqs snmkspgyqs rhillrptmq tlicdvhsit sdnhkwtqed
      181 klllesqlil ataeplcldp siavtctanr llynkqkmnt rpmkrcfkry srsslnrqqd
      241 lshcppppql rlldflqkrk erkagqhydl kiskagncvd mwkrspcnla ipsevdveky
      301 akveksiksd dsqptvwpah dvkddyvfec eagtqyqktk ltilqslgdp lyygkiqpck
      361 adeesdsqms pshsstddhs nwfiigsktd aervvnqyqe lvqneakcpv kmshsssgsa
      421 slsqvspgke tdqtetvsvq ssvlgkgvkh rpppiklpss sgnsssgnyf tpqqtssflk
      481 sptpppsskp ssiprkssvd lnqvsmlspa alspasssqr sgtpkpstpt ptpsstphpp
      541 daqsstpstp satptpqdsg ftpqptlltq faqqqrslsq ampvttipls tmvtsitpgt
      601 tatqvmansa glnfinvvgs vcgaqalmsg snpmlgcntg aitpaginls gllpsggllp
      661 nalpsamqaa sqagvpfglk ntsslrplnl lqlpggslif ntlqqqqqql sqftpqqpqq
      721 pttcspqqpg eqgseqgsts qeqalsaqqa avinltgvgs fmqsqaavls qlgsaenrpe
      781 qslpqqrfql ssafqqqqqq iqqlrflqhq mamaaaaaqt aqlhhhrhtg sqskskmkrg
      841 tpttpkf
//
LOCUS       XP_005266513             847 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor SPT20 homolog isoform X3 [Homo sapiens].
ACCESSION   XP_005266513
VERSION     XP_005266513.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266456.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..847
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..847
                     /product="transcription factor SPT20 homolog isoform X3"
                     /calculated_mol_wt=92516
     Region          65..202
                     /region_name="Spt20"
                     /note="Spt20 family; pfam12090"
                     /db_xref="CDD:463459"
     CDS             1..847
                     /gene="SUPT20H"
                     /gene_synonym="C13; C13orf19; FAM48A; FP757; P38IP; SPT20"
                     /coded_by="XM_005266456.5:303..2846"
                     /db_xref="GeneID:55578"
                     /db_xref="HGNC:HGNC:20596"
                     /db_xref="MIM:613417"
ORIGIN      
        1 myviesarqr ppkrkylssg rksvfqklyd lyieecekep evkqklrrnv nlleklvmqe
       61 tlsclvvnly pgnegyslml rgkngsdset irlpyeegel leyldaeelp pilvdlleks
      121 qvnifhcgcv iaeirdyrqs snmkspgyqs rhillrptmq tlicdvhsit sdnhkwtqed
      181 klllesqlil ataeplcldp siavtctanr llynkqkmnt rpmkrcfkry srsslnrqqd
      241 lshcppppql rlldflqkrk erkagqhydl kiskagncvd mwkrspcnla ipsevdveky
      301 akveksiksd dsqptvwpah dvkddyvfec eagtqyqktk ltilqslgdp lyygkiqpck
      361 adeesdsqms pshsstddhs nwfiigsktd aervvnqyqe lvqneakcpv kmshsssgsa
      421 slsqvspgke tdqtetvsvq ssvlgkgvkh rpppiklpss sgnsssgnyf tpqqtssflk
      481 sptpppsskp ssiprkssvd lnqvsmlspa alspasssqr sgtpkpstpt ptpsstphpp
      541 daqsstpstp satptpqdsg ftpqptlltq faqqqrslsq ampvttipls tmvtsitpgt
      601 tatqvmansa glnfinvvgs vcgaqalmsg snpmlgcntg aitpaginls gllpsggllp
      661 nalpsamqaa sqagvpfglk ntsslrplnl lqlpggslif ntlqqqqqql sqftpqqpqq
      721 pttcspqqpg eqgseqgsts qeqalsaqqa avinltgvgs fmqsqaavls qlgsaenrpe
      781 qslpqqrfql ssafqqqqqq iqqlrflqhq mamaaaaaqt aqlhhhrhtg sqskskmkrg
      841 tpttpkf
//
LOCUS       XP_005266512             847 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor SPT20 homolog isoform X4 [Homo sapiens].
ACCESSION   XP_005266512
VERSION     XP_005266512.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266455.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..847
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..847
                     /product="transcription factor SPT20 homolog isoform X4"
                     /calculated_mol_wt=92613
     Region          77..214
                     /region_name="Spt20"
                     /note="Spt20 family; pfam12090"
                     /db_xref="CDD:463459"
     CDS             1..847
                     /gene="SUPT20H"
                     /gene_synonym="C13; C13orf19; FAM48A; FP757; P38IP; SPT20"
                     /coded_by="XM_005266455.3:224..2767"
                     /db_xref="GeneID:55578"
                     /db_xref="HGNC:HGNC:20596"
                     /db_xref="MIM:613417"
ORIGIN      
        1 mqqalelald raeyviesar qrppkrkyls sgrksvfqkl ydlyieecek epevkqklrr
       61 nvnlleklvm qetlsclvvn lypgnegysl mlrgkngsds etirlpyeeg elleyldaee
      121 lppilvdlle ksqvnifhcg cviaeirdyr qssnmkspgy qsrhillrpt mqtlicdvhs
      181 itsdnhkwtq edklllesql ilataeplcl dpsiavtcta nrllynkqkm ntrpmkrcfk
      241 rysrsslnrq qdlshcpppp qlrlldflqk rkerkagqhy dlkiskagnc vdmwkrspcn
      301 laipsevdve kyakveksik sddsqptvwp ahdvkddyvf eceagtqyqk tkltilqslg
      361 dplyygkiqp ckadeesdsq mspshsstdd hsnwfiigsk tdaervvnqy qelvqneakc
      421 pvkmshsssg saslsqvspg ketdqtetvs vqssvlgkgv khrpppiklp sssgnsssgn
      481 yftpqqtssf lksptpppss kpssiprkss vdlnqvsmls paalspasss qrsgtpkpst
      541 ptptpsstph ppdaqsstps tpsatptpqd sgftpqptll tqfaqqqrsl sqampvttip
      601 lstmvtsitp gttatqvman saglnfinvv gsvcgaqalm sgsnpmlgcn tgaitpagin
      661 lsgllpsggl lpnalpsamq aasqagvpfg lkntsslrpl nllqqqqqql sqftpqqpqq
      721 pttcspqqpg eqgseqgsts qeqalsaqqa avinltgvgs fmqsqaavls qlgsaenrpe
      781 qslpqqrfql ssafqqqqqq iqqlrflqhq mamaaaaaqt aqlhhhrhtg sqskskmkrg
      841 tpttpkf
//
LOCUS       XP_005266514             846 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor SPT20 homolog isoform X5 [Homo sapiens].
ACCESSION   XP_005266514
VERSION     XP_005266514.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266457.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..846
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..846
                     /product="transcription factor SPT20 homolog isoform X5"
                     /calculated_mol_wt=92388
     Region          64..201
                     /region_name="Spt20"
                     /note="Spt20 family; pfam12090"
                     /db_xref="CDD:463459"
     CDS             1..846
                     /gene="SUPT20H"
                     /gene_synonym="C13; C13orf19; FAM48A; FP757; P38IP; SPT20"
                     /coded_by="XM_005266457.5:224..2764"
                     /db_xref="GeneID:55578"
                     /db_xref="HGNC:HGNC:20596"
                     /db_xref="MIM:613417"
ORIGIN      
        1 myviesarqr ppkrkylssg rksvfqklyd lyieecekep evkklrrnvn lleklvmqet
       61 lsclvvnlyp gnegyslmlr gkngsdseti rlpyeegell eyldaeelpp ilvdlleksq
      121 vnifhcgcvi aeirdyrqss nmkspgyqsr hillrptmqt licdvhsits dnhkwtqedk
      181 lllesqlila taeplcldps iavtctanrl lynkqkmntr pmkrcfkrys rsslnrqqdl
      241 shcppppqlr lldflqkrke rkagqhydlk iskagncvdm wkrspcnlai psevdvekya
      301 kveksiksdd sqptvwpahd vkddyvfece agtqyqktkl tilqslgdpl yygkiqpcka
      361 deesdsqmsp shsstddhsn wfiigsktda ervvnqyqel vqneakcpvk mshsssgsas
      421 lsqvspgket dqtetvsvqs svlgkgvkhr pppiklpsss gnsssgnyft pqqtssflks
      481 ptpppsskps siprkssvdl nqvsmlspaa lspasssqrs gtpkpstptp tpsstphppd
      541 aqsstpstps atptpqdsgf tpqptlltqf aqqqrslsqa mpvttiplst mvtsitpgtt
      601 atqvmansag lnfinvvgsv cgaqalmsgs npmlgcntga itpaginlsg llpsggllpn
      661 alpsamqaas qagvpfglkn tsslrplnll qlpggslifn tlqqqqqqls qftpqqpqqp
      721 ttcspqqpge qgseqgstsq eqalsaqqaa vinltgvgsf mqsqaavlsq lgsaenrpeq
      781 slpqqrfqls safqqqqqqi qqlrflqhqm amaaaaaqta qlhhhrhtgs qskskmkrgt
      841 pttpkf
//
LOCUS       XP_016876142             846 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor SPT20 homolog isoform X6 [Homo sapiens].
ACCESSION   XP_016876142
VERSION     XP_016876142.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020653.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..846
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..846
                     /product="transcription factor SPT20 homolog isoform X6"
                     /calculated_mol_wt=92485
     Region          76..213
                     /region_name="Spt20"
                     /note="Spt20 family; pfam12090"
                     /db_xref="CDD:463459"
     CDS             1..846
                     /gene="SUPT20H"
                     /gene_synonym="C13; C13orf19; FAM48A; FP757; P38IP; SPT20"
                     /coded_by="XM_017020653.3:224..2764"
                     /db_xref="GeneID:55578"
                     /db_xref="HGNC:HGNC:20596"
                     /db_xref="MIM:613417"
ORIGIN      
        1 mqqalelald raeyviesar qrppkrkyls sgrksvfqkl ydlyieecek epevkklrrn
       61 vnlleklvmq etlsclvvnl ypgnegyslm lrgkngsdse tirlpyeege lleyldaeel
      121 ppilvdllek sqvnifhcgc viaeirdyrq ssnmkspgyq srhillrptm qtlicdvhsi
      181 tsdnhkwtqe dklllesqli lataeplcld psiavtctan rllynkqkmn trpmkrcfkr
      241 ysrsslnrqq dlshcppppq lrlldflqkr kerkagqhyd lkiskagncv dmwkrspcnl
      301 aipsevdvek yakveksiks ddsqptvwpa hdvkddyvfe ceagtqyqkt kltilqslgd
      361 plyygkiqpc kadeesdsqm spshsstddh snwfiigskt daervvnqyq elvqneakcp
      421 vkmshsssgs aslsqvspgk etdqtetvsv qssvlgkgvk hrpppiklps ssgnsssgny
      481 ftpqqtssfl ksptpppssk pssiprkssv dlnqvsmlsp aalspasssq rsgtpkpstp
      541 tptpsstphp pdaqsstpst psatptpqds gftpqptllt qfaqqqrsls qampvttipl
      601 stmvtsitpg ttatqvmans aglnfinvvg svcgaqalms gsnpmlgcnt gaitpaginl
      661 sgllpsggll pnalpsamqa asqagvpfgl kntsslrpln llqqqqqqls qftpqqpqqp
      721 ttcspqqpge qgseqgstsq eqalsaqqaa vinltgvgsf mqsqaavlsq lgsaenrpeq
      781 slpqqrfqls safqqqqqqi qqlrflqhqm amaaaaaqta qlhhhrhtgs qskskmkrgt
      841 pttpkf
//
LOCUS       XP_005266515             846 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor SPT20 homolog isoform X5 [Homo sapiens].
ACCESSION   XP_005266515
VERSION     XP_005266515.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266458.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..846
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..846
                     /product="transcription factor SPT20 homolog isoform X5"
                     /calculated_mol_wt=92388
     Region          64..201
                     /region_name="Spt20"
                     /note="Spt20 family; pfam12090"
                     /db_xref="CDD:463459"
     CDS             1..846
                     /gene="SUPT20H"
                     /gene_synonym="C13; C13orf19; FAM48A; FP757; P38IP; SPT20"
                     /coded_by="XM_005266458.5:303..2843"
                     /db_xref="GeneID:55578"
                     /db_xref="HGNC:HGNC:20596"
                     /db_xref="MIM:613417"
ORIGIN      
        1 myviesarqr ppkrkylssg rksvfqklyd lyieecekep evkklrrnvn lleklvmqet
       61 lsclvvnlyp gnegyslmlr gkngsdseti rlpyeegell eyldaeelpp ilvdlleksq
      121 vnifhcgcvi aeirdyrqss nmkspgyqsr hillrptmqt licdvhsits dnhkwtqedk
      181 lllesqlila taeplcldps iavtctanrl lynkqkmntr pmkrcfkrys rsslnrqqdl
      241 shcppppqlr lldflqkrke rkagqhydlk iskagncvdm wkrspcnlai psevdvekya
      301 kveksiksdd sqptvwpahd vkddyvfece agtqyqktkl tilqslgdpl yygkiqpcka
      361 deesdsqmsp shsstddhsn wfiigsktda ervvnqyqel vqneakcpvk mshsssgsas
      421 lsqvspgket dqtetvsvqs svlgkgvkhr pppiklpsss gnsssgnyft pqqtssflks
      481 ptpppsskps siprkssvdl nqvsmlspaa lspasssqrs gtpkpstptp tpsstphppd
      541 aqsstpstps atptpqdsgf tpqptlltqf aqqqrslsqa mpvttiplst mvtsitpgtt
      601 atqvmansag lnfinvvgsv cgaqalmsgs npmlgcntga itpaginlsg llpsggllpn
      661 alpsamqaas qagvpfglkn tsslrplnll qlpggslifn tlqqqqqqls qftpqqpqqp
      721 ttcspqqpge qgseqgstsq eqalsaqqaa vinltgvgsf mqsqaavlsq lgsaenrpeq
      781 slpqqrfqls safqqqqqqi qqlrflqhqm amaaaaaqta qlhhhrhtgs qskskmkrgt
      841 pttpkf
//
LOCUS       XP_047286401             835 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor SPT20 homolog isoform X7 [Homo sapiens].
ACCESSION   XP_047286401
VERSION     XP_047286401.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430445.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..835
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..835
                     /product="transcription factor SPT20 homolog isoform X7"
                     /calculated_mol_wt=91275
     Region          65..202
                     /region_name="Spt20"
                     /note="Spt20 family; pfam12090"
                     /db_xref="CDD:463459"
     CDS             1..835
                     /gene="SUPT20H"
                     /gene_synonym="C13; C13orf19; FAM48A; FP757; P38IP; SPT20"
                     /coded_by="XM_047430445.1:224..2731"
                     /db_xref="GeneID:55578"
                     /db_xref="HGNC:HGNC:20596"
                     /db_xref="MIM:613417"
ORIGIN      
        1 myviesarqr ppkrkylssg rksvfqklyd lyieecekep evkqklrrnv nlleklvmqe
       61 tlsclvvnly pgnegyslml rgkngsdset irlpyeegel leyldaeelp pilvdlleks
      121 qvnifhcgcv iaeirdyrqs snmkspgyqs rhillrptmq tlicdvhsit sdnhkwtqed
      181 klllesqlil ataeplcldp siavtctanr llynkqkmnt rpmkrcfkry srsslnrqqd
      241 lshcppppql rlldflqkrk erkagqhydl kiskagncvd mwkrspcnla ipsevdveky
      301 akveksiksd dsqptvwpah dvkddyvfec eagtqyqktk ltilqslgdp lyygkiqpck
      361 adeesdsqms pshsstddhs nwfiigsktd aervvnqyqe lvqneakcpv kmshsssgsa
      421 slsqvspgke tdqtetvsvq ssvlgkgvkh rpppiklpss sgnsssgnyf tpqqtssflk
      481 sptpppsskp ssiprkssvd lnqvsmlspa alspasssqr sgtpkpstpt ptpsstphpp
      541 daqsstpstp satptpqdsg ftpqptlltq faqqqrslsq ampvttipls tmvtsitpgt
      601 tatqvmansa glnfinvvgs vcgaqalmsg snpmlgcntg aitpaginls gllpsggllp
      661 nalpsamqaa sqagvpfglk ntsslrplnl lqqqqqqlsq ftpqqpqqpt tcspqqpgeq
      721 gseqgstsqe qalsaqqaav inltgvgsfm qsqaavlsql gsaenrpeqs lpqqrfqlss
      781 afqqqqqqiq qlrflqhqma maaaaaqtaq lhhhrhtgsq skskmkrgtp ttpkf
//
LOCUS       XP_047286403             834 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor SPT20 homolog isoform X8 [Homo sapiens].
ACCESSION   XP_047286403
VERSION     XP_047286403.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430447.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..834
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..834
                     /product="transcription factor SPT20 homolog isoform X8"
                     /calculated_mol_wt=91146
     Region          64..201
                     /region_name="Spt20"
                     /note="Spt20 family; pfam12090"
                     /db_xref="CDD:463459"
     CDS             1..834
                     /gene="SUPT20H"
                     /gene_synonym="C13; C13orf19; FAM48A; FP757; P38IP; SPT20"
                     /coded_by="XM_047430447.1:224..2728"
                     /db_xref="GeneID:55578"
                     /db_xref="HGNC:HGNC:20596"
                     /db_xref="MIM:613417"
ORIGIN      
        1 myviesarqr ppkrkylssg rksvfqklyd lyieecekep evkklrrnvn lleklvmqet
       61 lsclvvnlyp gnegyslmlr gkngsdseti rlpyeegell eyldaeelpp ilvdlleksq
      121 vnifhcgcvi aeirdyrqss nmkspgyqsr hillrptmqt licdvhsits dnhkwtqedk
      181 lllesqlila taeplcldps iavtctanrl lynkqkmntr pmkrcfkrys rsslnrqqdl
      241 shcppppqlr lldflqkrke rkagqhydlk iskagncvdm wkrspcnlai psevdvekya
      301 kveksiksdd sqptvwpahd vkddyvfece agtqyqktkl tilqslgdpl yygkiqpcka
      361 deesdsqmsp shsstddhsn wfiigsktda ervvnqyqel vqneakcpvk mshsssgsas
      421 lsqvspgket dqtetvsvqs svlgkgvkhr pppiklpsss gnsssgnyft pqqtssflks
      481 ptpppsskps siprkssvdl nqvsmlspaa lspasssqrs gtpkpstptp tpsstphppd
      541 aqsstpstps atptpqdsgf tpqptlltqf aqqqrslsqa mpvttiplst mvtsitpgtt
      601 atqvmansag lnfinvvgsv cgaqalmsgs npmlgcntga itpaginlsg llpsggllpn
      661 alpsamqaas qagvpfglkn tsslrplnll qqqqqqlsqf tpqqpqqptt cspqqpgeqg
      721 seqgstsqeq alsaqqaavi nltgvgsfmq sqaavlsqlg saenrpeqsl pqqrfqlssa
      781 fqqqqqqiqq lrflqhqmam aaaaaqtaql hhhrhtgsqs kskmkrgtpt tpkf
//
LOCUS       XP_047286404             834 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor SPT20 homolog isoform X8 [Homo sapiens].
ACCESSION   XP_047286404
VERSION     XP_047286404.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430448.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..834
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..834
                     /product="transcription factor SPT20 homolog isoform X8"
                     /calculated_mol_wt=91146
     Region          64..201
                     /region_name="Spt20"
                     /note="Spt20 family; pfam12090"
                     /db_xref="CDD:463459"
     CDS             1..834
                     /gene="SUPT20H"
                     /gene_synonym="C13; C13orf19; FAM48A; FP757; P38IP; SPT20"
                     /coded_by="XM_047430448.1:303..2807"
                     /db_xref="GeneID:55578"
                     /db_xref="HGNC:HGNC:20596"
                     /db_xref="MIM:613417"
ORIGIN      
        1 myviesarqr ppkrkylssg rksvfqklyd lyieecekep evkklrrnvn lleklvmqet
       61 lsclvvnlyp gnegyslmlr gkngsdseti rlpyeegell eyldaeelpp ilvdlleksq
      121 vnifhcgcvi aeirdyrqss nmkspgyqsr hillrptmqt licdvhsits dnhkwtqedk
      181 lllesqlila taeplcldps iavtctanrl lynkqkmntr pmkrcfkrys rsslnrqqdl
      241 shcppppqlr lldflqkrke rkagqhydlk iskagncvdm wkrspcnlai psevdvekya
      301 kveksiksdd sqptvwpahd vkddyvfece agtqyqktkl tilqslgdpl yygkiqpcka
      361 deesdsqmsp shsstddhsn wfiigsktda ervvnqyqel vqneakcpvk mshsssgsas
      421 lsqvspgket dqtetvsvqs svlgkgvkhr pppiklpsss gnsssgnyft pqqtssflks
      481 ptpppsskps siprkssvdl nqvsmlspaa lspasssqrs gtpkpstptp tpsstphppd
      541 aqsstpstps atptpqdsgf tpqptlltqf aqqqrslsqa mpvttiplst mvtsitpgtt
      601 atqvmansag lnfinvvgsv cgaqalmsgs npmlgcntga itpaginlsg llpsggllpn
      661 alpsamqaas qagvpfglkn tsslrplnll qqqqqqlsqf tpqqpqqptt cspqqpgeqg
      721 seqgstsqeq alsaqqaavi nltgvgsfmq sqaavlsqlg saenrpeqsl pqqrfqlssa
      781 fqqqqqqiqq lrflqhqmam aaaaaqtaql hhhrhtgsqs kskmkrgtpt tpkf
//
LOCUS       XP_005266517             812 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor SPT20 homolog isoform X9 [Homo sapiens].
ACCESSION   XP_005266517
VERSION     XP_005266517.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266460.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..812
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..812
                     /product="transcription factor SPT20 homolog isoform X9"
                     /calculated_mol_wt=88039
     Region          77..214
                     /region_name="Spt20"
                     /note="Spt20 family; pfam12090"
                     /db_xref="CDD:463459"
     CDS             1..812
                     /gene="SUPT20H"
                     /gene_synonym="C13; C13orf19; FAM48A; FP757; P38IP; SPT20"
                     /coded_by="XM_005266460.3:224..2662"
                     /db_xref="GeneID:55578"
                     /db_xref="HGNC:HGNC:20596"
                     /db_xref="MIM:613417"
ORIGIN      
        1 mqqalelald raeyviesar qrppkrkyls sgrksvfqkl ydlyieecek epevkqklrr
       61 nvnlleklvm qetlsclvvn lypgnegysl mlrgkngsds etirlpyeeg elleyldaee
      121 lppilvdlle ksqvnifhcg cviaeirdyr qssnmkspgy qsrhillrpt mqtlicdvhs
      181 itsdnhkwtq edklllesql ilataeplcl dpsiavtcta nrllynkqkm ntrpmkrcfk
      241 rysrsslnrq qdlshcpppp qlrlldflqk rkerkagqhy dlkiskagnc vdmwkrspcn
      301 laipsevdve kyakveksik sddsqptvwp ahdvkddyvf eceagtqyqk tkltilqslg
      361 dplyygkiqp ckadeesdsq mspshsstdd hsnwfiigsk tdaervvnqy qelvqneakc
      421 pvkmshsssg saslsqvspg ketdqtetvs vqssvlgkgv khrpppiklp sssgnsssgn
      481 yftpqqtssf lksptpppss kpssiprkss vdlnqvsmls paalspasss qrsgtpkpst
      541 ptptpsstph ppdaqsstps tpsatptpqd sgftpqptll tqfaqqqrsl sqampvttip
      601 lstmvtsitp gttatqvman saglnfinvv gsvcgaqalm sgsnpmlgcn tgaitpagin
      661 lsgllpsggl lpnalpsamq aasqagvpfg lkntsslrpl nllqlpggsl ifntlqqqqq
      721 qlsqftpqqp qqpttcspqq pgeqgseqgs tsqeqalsaq qaavinltgv gsfmqsqaaa
      781 vailaasngy gsssstnssa tsssayrqpv kk
//
LOCUS       XP_047286405             811 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor SPT20 homolog isoform X10 [Homo sapiens].
ACCESSION   XP_047286405
VERSION     XP_047286405.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430449.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..811
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..811
                     /product="transcription factor SPT20 homolog isoform X10"
                     /calculated_mol_wt=87911
     Region          76..213
                     /region_name="Spt20"
                     /note="Spt20 family; pfam12090"
                     /db_xref="CDD:463459"
     CDS             1..811
                     /gene="SUPT20H"
                     /gene_synonym="C13; C13orf19; FAM48A; FP757; P38IP; SPT20"
                     /coded_by="XM_047430449.1:303..2738"
                     /db_xref="GeneID:55578"
                     /db_xref="HGNC:HGNC:20596"
                     /db_xref="MIM:613417"
ORIGIN      
        1 mqqalelald raeyviesar qrppkrkyls sgrksvfqkl ydlyieecek epevkklrrn
       61 vnlleklvmq etlsclvvnl ypgnegyslm lrgkngsdse tirlpyeege lleyldaeel
      121 ppilvdllek sqvnifhcgc viaeirdyrq ssnmkspgyq srhillrptm qtlicdvhsi
      181 tsdnhkwtqe dklllesqli lataeplcld psiavtctan rllynkqkmn trpmkrcfkr
      241 ysrsslnrqq dlshcppppq lrlldflqkr kerkagqhyd lkiskagncv dmwkrspcnl
      301 aipsevdvek yakveksiks ddsqptvwpa hdvkddyvfe ceagtqyqkt kltilqslgd
      361 plyygkiqpc kadeesdsqm spshsstddh snwfiigskt daervvnqyq elvqneakcp
      421 vkmshsssgs aslsqvspgk etdqtetvsv qssvlgkgvk hrpppiklps ssgnsssgny
      481 ftpqqtssfl ksptpppssk pssiprkssv dlnqvsmlsp aalspasssq rsgtpkpstp
      541 tptpsstphp pdaqsstpst psatptpqds gftpqptllt qfaqqqrsls qampvttipl
      601 stmvtsitpg ttatqvmans aglnfinvvg svcgaqalms gsnpmlgcnt gaitpaginl
      661 sgllpsggll pnalpsamqa asqagvpfgl kntsslrpln llqlpggsli fntlqqqqqq
      721 lsqftpqqpq qpttcspqqp geqgseqgst sqeqalsaqq aavinltgvg sfmqsqaaav
      781 ailaasngyg sssstnssat sssayrqpvk k
//
LOCUS       XP_047286406             800 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor SPT20 homolog isoform X11 [Homo sapiens].
ACCESSION   XP_047286406
VERSION     XP_047286406.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430450.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..800
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..800
                     /product="transcription factor SPT20 homolog isoform X11"
                     /calculated_mol_wt=86700
     Region          65..202
                     /region_name="Spt20"
                     /note="Spt20 family; pfam12090"
                     /db_xref="CDD:463459"
     CDS             1..800
                     /gene="SUPT20H"
                     /gene_synonym="C13; C13orf19; FAM48A; FP757; P38IP; SPT20"
                     /coded_by="XM_047430450.1:224..2626"
                     /db_xref="GeneID:55578"
                     /db_xref="HGNC:HGNC:20596"
                     /db_xref="MIM:613417"
ORIGIN      
        1 myviesarqr ppkrkylssg rksvfqklyd lyieecekep evkqklrrnv nlleklvmqe
       61 tlsclvvnly pgnegyslml rgkngsdset irlpyeegel leyldaeelp pilvdlleks
      121 qvnifhcgcv iaeirdyrqs snmkspgyqs rhillrptmq tlicdvhsit sdnhkwtqed
      181 klllesqlil ataeplcldp siavtctanr llynkqkmnt rpmkrcfkry srsslnrqqd
      241 lshcppppql rlldflqkrk erkagqhydl kiskagncvd mwkrspcnla ipsevdveky
      301 akveksiksd dsqptvwpah dvkddyvfec eagtqyqktk ltilqslgdp lyygkiqpck
      361 adeesdsqms pshsstddhs nwfiigsktd aervvnqyqe lvqneakcpv kmshsssgsa
      421 slsqvspgke tdqtetvsvq ssvlgkgvkh rpppiklpss sgnsssgnyf tpqqtssflk
      481 sptpppsskp ssiprkssvd lnqvsmlspa alspasssqr sgtpkpstpt ptpsstphpp
      541 daqsstpstp satptpqdsg ftpqptlltq faqqqrslsq ampvttipls tmvtsitpgt
      601 tatqvmansa glnfinvvgs vcgaqalmsg snpmlgcntg aitpaginls gllpsggllp
      661 nalpsamqaa sqagvpfglk ntsslrplnl lqlpggslif ntlqqqqqql sqftpqqpqq
      721 pttcspqqpg eqgseqgsts qeqalsaqqa avinltgvgs fmqsqaaava ilaasngygs
      781 ssstnssats ssayrqpvkk
//
LOCUS       XP_005266518             800 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor SPT20 homolog isoform X12 [Homo sapiens].
ACCESSION   XP_005266518
VERSION     XP_005266518.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266461.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..800
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..800
                     /product="transcription factor SPT20 homolog isoform X12"
                     /calculated_mol_wt=86797
     Region          77..214
                     /region_name="Spt20"
                     /note="Spt20 family; pfam12090"
                     /db_xref="CDD:463459"
     CDS             1..800
                     /gene="SUPT20H"
                     /gene_synonym="C13; C13orf19; FAM48A; FP757; P38IP; SPT20"
                     /coded_by="XM_005266461.4:224..2626"
                     /db_xref="GeneID:55578"
                     /db_xref="HGNC:HGNC:20596"
                     /db_xref="MIM:613417"
ORIGIN      
        1 mqqalelald raeyviesar qrppkrkyls sgrksvfqkl ydlyieecek epevkqklrr
       61 nvnlleklvm qetlsclvvn lypgnegysl mlrgkngsds etirlpyeeg elleyldaee
      121 lppilvdlle ksqvnifhcg cviaeirdyr qssnmkspgy qsrhillrpt mqtlicdvhs
      181 itsdnhkwtq edklllesql ilataeplcl dpsiavtcta nrllynkqkm ntrpmkrcfk
      241 rysrsslnrq qdlshcpppp qlrlldflqk rkerkagqhy dlkiskagnc vdmwkrspcn
      301 laipsevdve kyakveksik sddsqptvwp ahdvkddyvf eceagtqyqk tkltilqslg
      361 dplyygkiqp ckadeesdsq mspshsstdd hsnwfiigsk tdaervvnqy qelvqneakc
      421 pvkmshsssg saslsqvspg ketdqtetvs vqssvlgkgv khrpppiklp sssgnsssgn
      481 yftpqqtssf lksptpppss kpssiprkss vdlnqvsmls paalspasss qrsgtpkpst
      541 ptptpsstph ppdaqsstps tpsatptpqd sgftpqptll tqfaqqqrsl sqampvttip
      601 lstmvtsitp gttatqvman saglnfinvv gsvcgaqalm sgsnpmlgcn tgaitpagin
      661 lsgllpsggl lpnalpsamq aasqagvpfg lkntsslrpl nllqqqqqql sqftpqqpqq
      721 pttcspqqpg eqgseqgsts qeqalsaqqa avinltgvgs fmqsqaaava ilaasngygs
      781 ssstnssats ssayrqpvkk
//
LOCUS       XP_047286407             799 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor SPT20 homolog isoform X13 [Homo sapiens].
ACCESSION   XP_047286407
VERSION     XP_047286407.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430451.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..799
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..799
                     /product="transcription factor SPT20 homolog isoform X13"
                     /calculated_mol_wt=86572
     Region          64..201
                     /region_name="Spt20"
                     /note="Spt20 family; pfam12090"
                     /db_xref="CDD:463459"
     CDS             1..799
                     /gene="SUPT20H"
                     /gene_synonym="C13; C13orf19; FAM48A; FP757; P38IP; SPT20"
                     /coded_by="XM_047430451.1:224..2623"
                     /db_xref="GeneID:55578"
                     /db_xref="HGNC:HGNC:20596"
                     /db_xref="MIM:613417"
ORIGIN      
        1 myviesarqr ppkrkylssg rksvfqklyd lyieecekep evkklrrnvn lleklvmqet
       61 lsclvvnlyp gnegyslmlr gkngsdseti rlpyeegell eyldaeelpp ilvdlleksq
      121 vnifhcgcvi aeirdyrqss nmkspgyqsr hillrptmqt licdvhsits dnhkwtqedk
      181 lllesqlila taeplcldps iavtctanrl lynkqkmntr pmkrcfkrys rsslnrqqdl
      241 shcppppqlr lldflqkrke rkagqhydlk iskagncvdm wkrspcnlai psevdvekya
      301 kveksiksdd sqptvwpahd vkddyvfece agtqyqktkl tilqslgdpl yygkiqpcka
      361 deesdsqmsp shsstddhsn wfiigsktda ervvnqyqel vqneakcpvk mshsssgsas
      421 lsqvspgket dqtetvsvqs svlgkgvkhr pppiklpsss gnsssgnyft pqqtssflks
      481 ptpppsskps siprkssvdl nqvsmlspaa lspasssqrs gtpkpstptp tpsstphppd
      541 aqsstpstps atptpqdsgf tpqptlltqf aqqqrslsqa mpvttiplst mvtsitpgtt
      601 atqvmansag lnfinvvgsv cgaqalmsgs npmlgcntga itpaginlsg llpsggllpn
      661 alpsamqaas qagvpfglkn tsslrplnll qlpggslifn tlqqqqqqls qftpqqpqqp
      721 ttcspqqpge qgseqgstsq eqalsaqqaa vinltgvgsf mqsqaaavai laasngygss
      781 sstnssatss sayrqpvkk
//
LOCUS       XP_047286408             799 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor SPT20 homolog isoform X14 [Homo sapiens].
ACCESSION   XP_047286408
VERSION     XP_047286408.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430452.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..799
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..799
                     /product="transcription factor SPT20 homolog isoform X14"
                     /calculated_mol_wt=86669
     Region          76..213
                     /region_name="Spt20"
                     /note="Spt20 family; pfam12090"
                     /db_xref="CDD:463459"
     CDS             1..799
                     /gene="SUPT20H"
                     /gene_synonym="C13; C13orf19; FAM48A; FP757; P38IP; SPT20"
                     /coded_by="XM_047430452.1:224..2623"
                     /db_xref="GeneID:55578"
                     /db_xref="HGNC:HGNC:20596"
                     /db_xref="MIM:613417"
ORIGIN      
        1 mqqalelald raeyviesar qrppkrkyls sgrksvfqkl ydlyieecek epevkklrrn
       61 vnlleklvmq etlsclvvnl ypgnegyslm lrgkngsdse tirlpyeege lleyldaeel
      121 ppilvdllek sqvnifhcgc viaeirdyrq ssnmkspgyq srhillrptm qtlicdvhsi
      181 tsdnhkwtqe dklllesqli lataeplcld psiavtctan rllynkqkmn trpmkrcfkr
      241 ysrsslnrqq dlshcppppq lrlldflqkr kerkagqhyd lkiskagncv dmwkrspcnl
      301 aipsevdvek yakveksiks ddsqptvwpa hdvkddyvfe ceagtqyqkt kltilqslgd
      361 plyygkiqpc kadeesdsqm spshsstddh snwfiigskt daervvnqyq elvqneakcp
      421 vkmshsssgs aslsqvspgk etdqtetvsv qssvlgkgvk hrpppiklps ssgnsssgny
      481 ftpqqtssfl ksptpppssk pssiprkssv dlnqvsmlsp aalspasssq rsgtpkpstp
      541 tptpsstphp pdaqsstpst psatptpqds gftpqptllt qfaqqqrsls qampvttipl
      601 stmvtsitpg ttatqvmans aglnfinvvg svcgaqalms gsnpmlgcnt gaitpaginl
      661 sgllpsggll pnalpsamqa asqagvpfgl kntsslrpln llqqqqqqls qftpqqpqqp
      721 ttcspqqpge qgseqgstsq eqalsaqqaa vinltgvgsf mqsqaaavai laasngygss
      781 sstnssatss sayrqpvkk
//
LOCUS       XP_047286409             788 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor SPT20 homolog isoform X15 [Homo sapiens].
ACCESSION   XP_047286409
VERSION     XP_047286409.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430453.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..788
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..788
                     /product="transcription factor SPT20 homolog isoform X15"
                     /calculated_mol_wt=85459
     Region          65..202
                     /region_name="Spt20"
                     /note="Spt20 family; pfam12090"
                     /db_xref="CDD:463459"
     CDS             1..788
                     /gene="SUPT20H"
                     /gene_synonym="C13; C13orf19; FAM48A; FP757; P38IP; SPT20"
                     /coded_by="XM_047430453.1:224..2590"
                     /db_xref="GeneID:55578"
                     /db_xref="HGNC:HGNC:20596"
                     /db_xref="MIM:613417"
ORIGIN      
        1 myviesarqr ppkrkylssg rksvfqklyd lyieecekep evkqklrrnv nlleklvmqe
       61 tlsclvvnly pgnegyslml rgkngsdset irlpyeegel leyldaeelp pilvdlleks
      121 qvnifhcgcv iaeirdyrqs snmkspgyqs rhillrptmq tlicdvhsit sdnhkwtqed
      181 klllesqlil ataeplcldp siavtctanr llynkqkmnt rpmkrcfkry srsslnrqqd
      241 lshcppppql rlldflqkrk erkagqhydl kiskagncvd mwkrspcnla ipsevdveky
      301 akveksiksd dsqptvwpah dvkddyvfec eagtqyqktk ltilqslgdp lyygkiqpck
      361 adeesdsqms pshsstddhs nwfiigsktd aervvnqyqe lvqneakcpv kmshsssgsa
      421 slsqvspgke tdqtetvsvq ssvlgkgvkh rpppiklpss sgnsssgnyf tpqqtssflk
      481 sptpppsskp ssiprkssvd lnqvsmlspa alspasssqr sgtpkpstpt ptpsstphpp
      541 daqsstpstp satptpqdsg ftpqptlltq faqqqrslsq ampvttipls tmvtsitpgt
      601 tatqvmansa glnfinvvgs vcgaqalmsg snpmlgcntg aitpaginls gllpsggllp
      661 nalpsamqaa sqagvpfglk ntsslrplnl lqqqqqqlsq ftpqqpqqpt tcspqqpgeq
      721 gseqgstsqe qalsaqqaav inltgvgsfm qsqaaavail aasngygsss stnssatsss
      781 ayrqpvkk
//
LOCUS       XP_047286410             787 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor SPT20 homolog isoform X16 [Homo sapiens].
ACCESSION   XP_047286410
VERSION     XP_047286410.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430454.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..787
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..787
                     /product="transcription factor SPT20 homolog isoform X16"
                     /calculated_mol_wt=85331
     Region          64..201
                     /region_name="Spt20"
                     /note="Spt20 family; pfam12090"
                     /db_xref="CDD:463459"
     CDS             1..787
                     /gene="SUPT20H"
                     /gene_synonym="C13; C13orf19; FAM48A; FP757; P38IP; SPT20"
                     /coded_by="XM_047430454.1:224..2587"
                     /db_xref="GeneID:55578"
                     /db_xref="HGNC:HGNC:20596"
                     /db_xref="MIM:613417"
ORIGIN      
        1 myviesarqr ppkrkylssg rksvfqklyd lyieecekep evkklrrnvn lleklvmqet
       61 lsclvvnlyp gnegyslmlr gkngsdseti rlpyeegell eyldaeelpp ilvdlleksq
      121 vnifhcgcvi aeirdyrqss nmkspgyqsr hillrptmqt licdvhsits dnhkwtqedk
      181 lllesqlila taeplcldps iavtctanrl lynkqkmntr pmkrcfkrys rsslnrqqdl
      241 shcppppqlr lldflqkrke rkagqhydlk iskagncvdm wkrspcnlai psevdvekya
      301 kveksiksdd sqptvwpahd vkddyvfece agtqyqktkl tilqslgdpl yygkiqpcka
      361 deesdsqmsp shsstddhsn wfiigsktda ervvnqyqel vqneakcpvk mshsssgsas
      421 lsqvspgket dqtetvsvqs svlgkgvkhr pppiklpsss gnsssgnyft pqqtssflks
      481 ptpppsskps siprkssvdl nqvsmlspaa lspasssqrs gtpkpstptp tpsstphppd
      541 aqsstpstps atptpqdsgf tpqptlltqf aqqqrslsqa mpvttiplst mvtsitpgtt
      601 atqvmansag lnfinvvgsv cgaqalmsgs npmlgcntga itpaginlsg llpsggllpn
      661 alpsamqaas qagvpfglkn tsslrplnll qqqqqqlsqf tpqqpqqptt cspqqpgeqg
      721 seqgstsqeq alsaqqaavi nltgvgsfmq sqaaavaila asngygssss tnssatsssa
      781 yrqpvkk
//
LOCUS       XP_005266519             780 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor SPT20 homolog isoform X17 [Homo sapiens].
ACCESSION   XP_005266519
VERSION     XP_005266519.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266462.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..780
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..780
                     /product="transcription factor SPT20 homolog isoform X17"
                     /calculated_mol_wt=85787
     Region          77..214
                     /region_name="Spt20"
                     /note="Spt20 family; pfam12090"
                     /db_xref="CDD:463459"
     CDS             1..780
                     /gene="SUPT20H"
                     /gene_synonym="C13; C13orf19; FAM48A; FP757; P38IP; SPT20"
                     /coded_by="XM_005266462.5:224..2566"
                     /db_xref="GeneID:55578"
                     /db_xref="HGNC:HGNC:20596"
                     /db_xref="MIM:613417"
ORIGIN      
        1 mqqalelald raeyviesar qrppkrkyls sgrksvfqkl ydlyieecek epevkqklrr
       61 nvnlleklvm qetlsclvvn lypgnegysl mlrgkngsds etirlpyeeg elleyldaee
      121 lppilvdlle ksqvnifhcg cviaeirdyr qssnmkspgy qsrhillrpt mqtlicdvhs
      181 itsdnhkwtq edklllesql ilataeplcl dpsiavtcta nrllynkqkm ntrpmkrcfk
      241 rysrsslnrq qdlshcpppp qlrlldflqk rkerkagqhy dlkiskagnc vdmwkrspcn
      301 laipsevdve kyakveksik sddsqptvwp ahdvkddyvf eceagtqyqk tkltilqslg
      361 dplyygkiqp ckadeesdsq mspshsstdd hsnwfiigsk tdaervvnqy qelvqneakc
      421 pvkmshsssg saslsqvspg ketdqtetvs vqssvlgkgv khrpppiklp sssgnsssgn
      481 yftpqqtssf lksptpppss kpssiprkss vdlnqvsmls paalspasss qrttatqvma
      541 nsaglnfinv vgsvcgaqal msgsnpmlgc ntgaitpagi nlsgllpsgg llpnalpsam
      601 qaasqagvpf glkntsslrp lnllqlpggs lifntlqqqq qqlsqftpqq pqqpttcspq
      661 qpgeqgseqg stsqeqalsa qqaavinltg vgsfmqsqaa vlsqlgsaen rpeqslpqqr
      721 fqlssafqqq qqqiqqlrfl qhqmamaaaa aqtaqlhhhr htgsqskskm krgtpttpkf
//
LOCUS       XP_047286412             780 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor SPT20 homolog isoform X17 [Homo sapiens].
ACCESSION   XP_047286412
VERSION     XP_047286412.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430456.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..780
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..780
                     /product="transcription factor SPT20 homolog isoform X17"
                     /calculated_mol_wt=85787
     Region          77..214
                     /region_name="Spt20"
                     /note="Spt20 family; pfam12090"
                     /db_xref="CDD:463459"
     CDS             1..780
                     /gene="SUPT20H"
                     /gene_synonym="C13; C13orf19; FAM48A; FP757; P38IP; SPT20"
                     /coded_by="XM_047430456.1:303..2645"
                     /db_xref="GeneID:55578"
                     /db_xref="HGNC:HGNC:20596"
                     /db_xref="MIM:613417"
ORIGIN      
        1 mqqalelald raeyviesar qrppkrkyls sgrksvfqkl ydlyieecek epevkqklrr
       61 nvnlleklvm qetlsclvvn lypgnegysl mlrgkngsds etirlpyeeg elleyldaee
      121 lppilvdlle ksqvnifhcg cviaeirdyr qssnmkspgy qsrhillrpt mqtlicdvhs
      181 itsdnhkwtq edklllesql ilataeplcl dpsiavtcta nrllynkqkm ntrpmkrcfk
      241 rysrsslnrq qdlshcpppp qlrlldflqk rkerkagqhy dlkiskagnc vdmwkrspcn
      301 laipsevdve kyakveksik sddsqptvwp ahdvkddyvf eceagtqyqk tkltilqslg
      361 dplyygkiqp ckadeesdsq mspshsstdd hsnwfiigsk tdaervvnqy qelvqneakc
      421 pvkmshsssg saslsqvspg ketdqtetvs vqssvlgkgv khrpppiklp sssgnsssgn
      481 yftpqqtssf lksptpppss kpssiprkss vdlnqvsmls paalspasss qrttatqvma
      541 nsaglnfinv vgsvcgaqal msgsnpmlgc ntgaitpagi nlsgllpsgg llpnalpsam
      601 qaasqagvpf glkntsslrp lnllqlpggs lifntlqqqq qqlsqftpqq pqqpttcspq
      661 qpgeqgseqg stsqeqalsa qqaavinltg vgsfmqsqaa vlsqlgsaen rpeqslpqqr
      721 fqlssafqqq qqqiqqlrfl qhqmamaaaa aqtaqlhhhr htgsqskskm krgtpttpkf
//
LOCUS       XP_047286413             779 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor SPT20 homolog isoform X18 [Homo sapiens].
ACCESSION   XP_047286413
VERSION     XP_047286413.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430457.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..779
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..779
                     /product="transcription factor SPT20 homolog isoform X18"
                     /calculated_mol_wt=85658
     Region          76..213
                     /region_name="Spt20"
                     /note="Spt20 family; pfam12090"
                     /db_xref="CDD:463459"
     CDS             1..779
                     /gene="SUPT20H"
                     /gene_synonym="C13; C13orf19; FAM48A; FP757; P38IP; SPT20"
                     /coded_by="XM_047430457.1:303..2642"
                     /db_xref="GeneID:55578"
                     /db_xref="HGNC:HGNC:20596"
                     /db_xref="MIM:613417"
ORIGIN      
        1 mqqalelald raeyviesar qrppkrkyls sgrksvfqkl ydlyieecek epevkklrrn
       61 vnlleklvmq etlsclvvnl ypgnegyslm lrgkngsdse tirlpyeege lleyldaeel
      121 ppilvdllek sqvnifhcgc viaeirdyrq ssnmkspgyq srhillrptm qtlicdvhsi
      181 tsdnhkwtqe dklllesqli lataeplcld psiavtctan rllynkqkmn trpmkrcfkr
      241 ysrsslnrqq dlshcppppq lrlldflqkr kerkagqhyd lkiskagncv dmwkrspcnl
      301 aipsevdvek yakveksiks ddsqptvwpa hdvkddyvfe ceagtqyqkt kltilqslgd
      361 plyygkiqpc kadeesdsqm spshsstddh snwfiigskt daervvnqyq elvqneakcp
      421 vkmshsssgs aslsqvspgk etdqtetvsv qssvlgkgvk hrpppiklps ssgnsssgny
      481 ftpqqtssfl ksptpppssk pssiprkssv dlnqvsmlsp aalspasssq rttatqvman
      541 saglnfinvv gsvcgaqalm sgsnpmlgcn tgaitpagin lsgllpsggl lpnalpsamq
      601 aasqagvpfg lkntsslrpl nllqlpggsl ifntlqqqqq qlsqftpqqp qqpttcspqq
      661 pgeqgseqgs tsqeqalsaq qaavinltgv gsfmqsqaav lsqlgsaenr peqslpqqrf
      721 qlssafqqqq qqiqqlrflq hqmamaaaaa qtaqlhhhrh tgsqskskmk rgtpttpkf
//
LOCUS       XP_016876143             768 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor SPT20 homolog isoform X19 [Homo sapiens].
ACCESSION   XP_016876143
VERSION     XP_016876143.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020654.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..768
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..768
                     /product="transcription factor SPT20 homolog isoform X19"
                     /calculated_mol_wt=84448
     Region          65..202
                     /region_name="Spt20"
                     /note="Spt20 family; pfam12090"
                     /db_xref="CDD:463459"
     CDS             1..768
                     /gene="SUPT20H"
                     /gene_synonym="C13; C13orf19; FAM48A; FP757; P38IP; SPT20"
                     /coded_by="XM_017020654.2:224..2530"
                     /db_xref="GeneID:55578"
                     /db_xref="HGNC:HGNC:20596"
                     /db_xref="MIM:613417"
ORIGIN      
        1 myviesarqr ppkrkylssg rksvfqklyd lyieecekep evkqklrrnv nlleklvmqe
       61 tlsclvvnly pgnegyslml rgkngsdset irlpyeegel leyldaeelp pilvdlleks
      121 qvnifhcgcv iaeirdyrqs snmkspgyqs rhillrptmq tlicdvhsit sdnhkwtqed
      181 klllesqlil ataeplcldp siavtctanr llynkqkmnt rpmkrcfkry srsslnrqqd
      241 lshcppppql rlldflqkrk erkagqhydl kiskagncvd mwkrspcnla ipsevdveky
      301 akveksiksd dsqptvwpah dvkddyvfec eagtqyqktk ltilqslgdp lyygkiqpck
      361 adeesdsqms pshsstddhs nwfiigsktd aervvnqyqe lvqneakcpv kmshsssgsa
      421 slsqvspgke tdqtetvsvq ssvlgkgvkh rpppiklpss sgnsssgnyf tpqqtssflk
      481 sptpppsskp ssiprkssvd lnqvsmlspa alspasssqr ttatqvmans aglnfinvvg
      541 svcgaqalms gsnpmlgcnt gaitpaginl sgllpsggll pnalpsamqa asqagvpfgl
      601 kntsslrpln llqlpggsli fntlqqqqqq lsqftpqqpq qpttcspqqp geqgseqgst
      661 sqeqalsaqq aavinltgvg sfmqsqaavl sqlgsaenrp eqslpqqrfq lssafqqqqq
      721 qiqqlrflqh qmamaaaaaq taqlhhhrht gsqskskmkr gtpttpkf
//
LOCUS       XP_047286414             768 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor SPT20 homolog isoform X19 [Homo sapiens].
ACCESSION   XP_047286414
VERSION     XP_047286414.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430458.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..768
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..768
                     /product="transcription factor SPT20 homolog isoform X19"
                     /calculated_mol_wt=84448
     Region          65..202
                     /region_name="Spt20"
                     /note="Spt20 family; pfam12090"
                     /db_xref="CDD:463459"
     CDS             1..768
                     /gene="SUPT20H"
                     /gene_synonym="C13; C13orf19; FAM48A; FP757; P38IP; SPT20"
                     /coded_by="XM_047430458.1:303..2609"
                     /db_xref="GeneID:55578"
                     /db_xref="HGNC:HGNC:20596"
                     /db_xref="MIM:613417"
ORIGIN      
        1 myviesarqr ppkrkylssg rksvfqklyd lyieecekep evkqklrrnv nlleklvmqe
       61 tlsclvvnly pgnegyslml rgkngsdset irlpyeegel leyldaeelp pilvdlleks
      121 qvnifhcgcv iaeirdyrqs snmkspgyqs rhillrptmq tlicdvhsit sdnhkwtqed
      181 klllesqlil ataeplcldp siavtctanr llynkqkmnt rpmkrcfkry srsslnrqqd
      241 lshcppppql rlldflqkrk erkagqhydl kiskagncvd mwkrspcnla ipsevdveky
      301 akveksiksd dsqptvwpah dvkddyvfec eagtqyqktk ltilqslgdp lyygkiqpck
      361 adeesdsqms pshsstddhs nwfiigsktd aervvnqyqe lvqneakcpv kmshsssgsa
      421 slsqvspgke tdqtetvsvq ssvlgkgvkh rpppiklpss sgnsssgnyf tpqqtssflk
      481 sptpppsskp ssiprkssvd lnqvsmlspa alspasssqr ttatqvmans aglnfinvvg
      541 svcgaqalms gsnpmlgcnt gaitpaginl sgllpsggll pnalpsamqa asqagvpfgl
      601 kntsslrpln llqlpggsli fntlqqqqqq lsqftpqqpq qpttcspqqp geqgseqgst
      661 sqeqalsaqq aavinltgvg sfmqsqaavl sqlgsaenrp eqslpqqrfq lssafqqqqq
      721 qiqqlrflqh qmamaaaaaq taqlhhhrht gsqskskmkr gtpttpkf
//
LOCUS       XP_005266521             768 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor SPT20 homolog isoform X20 [Homo sapiens].
ACCESSION   XP_005266521
VERSION     XP_005266521.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266464.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..768
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..768
                     /product="transcription factor SPT20 homolog isoform X20"
                     /calculated_mol_wt=84545
     Region          77..214
                     /region_name="Spt20"
                     /note="Spt20 family; pfam12090"
                     /db_xref="CDD:463459"
     CDS             1..768
                     /gene="SUPT20H"
                     /gene_synonym="C13; C13orf19; FAM48A; FP757; P38IP; SPT20"
                     /coded_by="XM_005266464.4:224..2530"
                     /db_xref="GeneID:55578"
                     /db_xref="HGNC:HGNC:20596"
                     /db_xref="MIM:613417"
ORIGIN      
        1 mqqalelald raeyviesar qrppkrkyls sgrksvfqkl ydlyieecek epevkqklrr
       61 nvnlleklvm qetlsclvvn lypgnegysl mlrgkngsds etirlpyeeg elleyldaee
      121 lppilvdlle ksqvnifhcg cviaeirdyr qssnmkspgy qsrhillrpt mqtlicdvhs
      181 itsdnhkwtq edklllesql ilataeplcl dpsiavtcta nrllynkqkm ntrpmkrcfk
      241 rysrsslnrq qdlshcpppp qlrlldflqk rkerkagqhy dlkiskagnc vdmwkrspcn
      301 laipsevdve kyakveksik sddsqptvwp ahdvkddyvf eceagtqyqk tkltilqslg
      361 dplyygkiqp ckadeesdsq mspshsstdd hsnwfiigsk tdaervvnqy qelvqneakc
      421 pvkmshsssg saslsqvspg ketdqtetvs vqssvlgkgv khrpppiklp sssgnsssgn
      481 yftpqqtssf lksptpppss kpssiprkss vdlnqvsmls paalspasss qrttatqvma
      541 nsaglnfinv vgsvcgaqal msgsnpmlgc ntgaitpagi nlsgllpsgg llpnalpsam
      601 qaasqagvpf glkntsslrp lnllqqqqqq lsqftpqqpq qpttcspqqp geqgseqgst
      661 sqeqalsaqq aavinltgvg sfmqsqaavl sqlgsaenrp eqslpqqrfq lssafqqqqq
      721 qiqqlrflqh qmamaaaaaq taqlhhhrht gsqskskmkr gtpttpkf
//
LOCUS       XP_016876144             767 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor SPT20 homolog isoform X21 [Homo sapiens].
ACCESSION   XP_016876144
VERSION     XP_016876144.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020655.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..767
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..767
                     /product="transcription factor SPT20 homolog isoform X21"
                     /calculated_mol_wt=84320
     Region          64..201
                     /region_name="Spt20"
                     /note="Spt20 family; pfam12090"
                     /db_xref="CDD:463459"
     CDS             1..767
                     /gene="SUPT20H"
                     /gene_synonym="C13; C13orf19; FAM48A; FP757; P38IP; SPT20"
                     /coded_by="XM_017020655.2:224..2527"
                     /db_xref="GeneID:55578"
                     /db_xref="HGNC:HGNC:20596"
                     /db_xref="MIM:613417"
ORIGIN      
        1 myviesarqr ppkrkylssg rksvfqklyd lyieecekep evkklrrnvn lleklvmqet
       61 lsclvvnlyp gnegyslmlr gkngsdseti rlpyeegell eyldaeelpp ilvdlleksq
      121 vnifhcgcvi aeirdyrqss nmkspgyqsr hillrptmqt licdvhsits dnhkwtqedk
      181 lllesqlila taeplcldps iavtctanrl lynkqkmntr pmkrcfkrys rsslnrqqdl
      241 shcppppqlr lldflqkrke rkagqhydlk iskagncvdm wkrspcnlai psevdvekya
      301 kveksiksdd sqptvwpahd vkddyvfece agtqyqktkl tilqslgdpl yygkiqpcka
      361 deesdsqmsp shsstddhsn wfiigsktda ervvnqyqel vqneakcpvk mshsssgsas
      421 lsqvspgket dqtetvsvqs svlgkgvkhr pppiklpsss gnsssgnyft pqqtssflks
      481 ptpppsskps siprkssvdl nqvsmlspaa lspasssqrt tatqvmansa glnfinvvgs
      541 vcgaqalmsg snpmlgcntg aitpaginls gllpsggllp nalpsamqaa sqagvpfglk
      601 ntsslrplnl lqlpggslif ntlqqqqqql sqftpqqpqq pttcspqqpg eqgseqgsts
      661 qeqalsaqqa avinltgvgs fmqsqaavls qlgsaenrpe qslpqqrfql ssafqqqqqq
      721 iqqlrflqhq mamaaaaaqt aqlhhhrhtg sqskskmkrg tpttpkf
//
LOCUS       XP_016876146             767 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor SPT20 homolog isoform X22 [Homo sapiens].
ACCESSION   XP_016876146
VERSION     XP_016876146.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020657.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..767
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..767
                     /product="transcription factor SPT20 homolog isoform X22"
                     /calculated_mol_wt=84417
     Region          76..213
                     /region_name="Spt20"
                     /note="Spt20 family; pfam12090"
                     /db_xref="CDD:463459"
     CDS             1..767
                     /gene="SUPT20H"
                     /gene_synonym="C13; C13orf19; FAM48A; FP757; P38IP; SPT20"
                     /coded_by="XM_017020657.3:224..2527"
                     /db_xref="GeneID:55578"
                     /db_xref="HGNC:HGNC:20596"
                     /db_xref="MIM:613417"
ORIGIN      
        1 mqqalelald raeyviesar qrppkrkyls sgrksvfqkl ydlyieecek epevkklrrn
       61 vnlleklvmq etlsclvvnl ypgnegyslm lrgkngsdse tirlpyeege lleyldaeel
      121 ppilvdllek sqvnifhcgc viaeirdyrq ssnmkspgyq srhillrptm qtlicdvhsi
      181 tsdnhkwtqe dklllesqli lataeplcld psiavtctan rllynkqkmn trpmkrcfkr
      241 ysrsslnrqq dlshcppppq lrlldflqkr kerkagqhyd lkiskagncv dmwkrspcnl
      301 aipsevdvek yakveksiks ddsqptvwpa hdvkddyvfe ceagtqyqkt kltilqslgd
      361 plyygkiqpc kadeesdsqm spshsstddh snwfiigskt daervvnqyq elvqneakcp
      421 vkmshsssgs aslsqvspgk etdqtetvsv qssvlgkgvk hrpppiklps ssgnsssgny
      481 ftpqqtssfl ksptpppssk pssiprkssv dlnqvsmlsp aalspasssq rttatqvman
      541 saglnfinvv gsvcgaqalm sgsnpmlgcn tgaitpagin lsgllpsggl lpnalpsamq
      601 aasqagvpfg lkntsslrpl nllqqqqqql sqftpqqpqq pttcspqqpg eqgseqgsts
      661 qeqalsaqqa avinltgvgs fmqsqaavls qlgsaenrpe qslpqqrfql ssafqqqqqq
      721 iqqlrflqhq mamaaaaaqt aqlhhhrhtg sqskskmkrg tpttpkf
//
LOCUS       XP_047286415             767 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor SPT20 homolog isoform X22 [Homo sapiens].
ACCESSION   XP_047286415
VERSION     XP_047286415.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430459.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..767
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..767
                     /product="transcription factor SPT20 homolog isoform X22"
                     /calculated_mol_wt=84417
     Region          76..213
                     /region_name="Spt20"
                     /note="Spt20 family; pfam12090"
                     /db_xref="CDD:463459"
     CDS             1..767
                     /gene="SUPT20H"
                     /gene_synonym="C13; C13orf19; FAM48A; FP757; P38IP; SPT20"
                     /coded_by="XM_047430459.1:303..2606"
                     /db_xref="GeneID:55578"
                     /db_xref="HGNC:HGNC:20596"
                     /db_xref="MIM:613417"
ORIGIN      
        1 mqqalelald raeyviesar qrppkrkyls sgrksvfqkl ydlyieecek epevkklrrn
       61 vnlleklvmq etlsclvvnl ypgnegyslm lrgkngsdse tirlpyeege lleyldaeel
      121 ppilvdllek sqvnifhcgc viaeirdyrq ssnmkspgyq srhillrptm qtlicdvhsi
      181 tsdnhkwtqe dklllesqli lataeplcld psiavtctan rllynkqkmn trpmkrcfkr
      241 ysrsslnrqq dlshcppppq lrlldflqkr kerkagqhyd lkiskagncv dmwkrspcnl
      301 aipsevdvek yakveksiks ddsqptvwpa hdvkddyvfe ceagtqyqkt kltilqslgd
      361 plyygkiqpc kadeesdsqm spshsstddh snwfiigskt daervvnqyq elvqneakcp
      421 vkmshsssgs aslsqvspgk etdqtetvsv qssvlgkgvk hrpppiklps ssgnsssgny
      481 ftpqqtssfl ksptpppssk pssiprkssv dlnqvsmlsp aalspasssq rttatqvman
      541 saglnfinvv gsvcgaqalm sgsnpmlgcn tgaitpagin lsgllpsggl lpnalpsamq
      601 aasqagvpfg lkntsslrpl nllqqqqqql sqftpqqpqq pttcspqqpg eqgseqgsts
      661 qeqalsaqqa avinltgvgs fmqsqaavls qlgsaenrpe qslpqqrfql ssafqqqqqq
      721 iqqlrflqhq mamaaaaaqt aqlhhhrhtg sqskskmkrg tpttpkf
//
LOCUS       XP_047286416             756 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor SPT20 homolog isoform X23 [Homo sapiens].
ACCESSION   XP_047286416
VERSION     XP_047286416.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430460.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..756
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..756
                     /product="transcription factor SPT20 homolog isoform X23"
                     /calculated_mol_wt=83207
     Region          65..202
                     /region_name="Spt20"
                     /note="Spt20 family; pfam12090"
                     /db_xref="CDD:463459"
     CDS             1..756
                     /gene="SUPT20H"
                     /gene_synonym="C13; C13orf19; FAM48A; FP757; P38IP; SPT20"
                     /coded_by="XM_047430460.1:224..2494"
                     /db_xref="GeneID:55578"
                     /db_xref="HGNC:HGNC:20596"
                     /db_xref="MIM:613417"
ORIGIN      
        1 myviesarqr ppkrkylssg rksvfqklyd lyieecekep evkqklrrnv nlleklvmqe
       61 tlsclvvnly pgnegyslml rgkngsdset irlpyeegel leyldaeelp pilvdlleks
      121 qvnifhcgcv iaeirdyrqs snmkspgyqs rhillrptmq tlicdvhsit sdnhkwtqed
      181 klllesqlil ataeplcldp siavtctanr llynkqkmnt rpmkrcfkry srsslnrqqd
      241 lshcppppql rlldflqkrk erkagqhydl kiskagncvd mwkrspcnla ipsevdveky
      301 akveksiksd dsqptvwpah dvkddyvfec eagtqyqktk ltilqslgdp lyygkiqpck
      361 adeesdsqms pshsstddhs nwfiigsktd aervvnqyqe lvqneakcpv kmshsssgsa
      421 slsqvspgke tdqtetvsvq ssvlgkgvkh rpppiklpss sgnsssgnyf tpqqtssflk
      481 sptpppsskp ssiprkssvd lnqvsmlspa alspasssqr ttatqvmans aglnfinvvg
      541 svcgaqalms gsnpmlgcnt gaitpaginl sgllpsggll pnalpsamqa asqagvpfgl
      601 kntsslrpln llqqqqqqls qftpqqpqqp ttcspqqpge qgseqgstsq eqalsaqqaa
      661 vinltgvgsf mqsqaavlsq lgsaenrpeq slpqqrfqls safqqqqqqi qqlrflqhqm
      721 amaaaaaqta qlhhhrhtgs qskskmkrgt pttpkf
//
LOCUS       XP_024305147             755 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor SPT20 homolog isoform X24 [Homo sapiens].
ACCESSION   XP_024305147
VERSION     XP_024305147.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449379.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..755
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..755
                     /product="transcription factor SPT20 homolog isoform X24"
                     /calculated_mol_wt=83078
     Region          64..201
                     /region_name="Spt20"
                     /note="Spt20 family; pfam12090"
                     /db_xref="CDD:463459"
     CDS             1..755
                     /gene="SUPT20H"
                     /gene_synonym="C13; C13orf19; FAM48A; FP757; P38IP; SPT20"
                     /coded_by="XM_024449379.2:224..2491"
                     /db_xref="GeneID:55578"
                     /db_xref="HGNC:HGNC:20596"
                     /db_xref="MIM:613417"
ORIGIN      
        1 myviesarqr ppkrkylssg rksvfqklyd lyieecekep evkklrrnvn lleklvmqet
       61 lsclvvnlyp gnegyslmlr gkngsdseti rlpyeegell eyldaeelpp ilvdlleksq
      121 vnifhcgcvi aeirdyrqss nmkspgyqsr hillrptmqt licdvhsits dnhkwtqedk
      181 lllesqlila taeplcldps iavtctanrl lynkqkmntr pmkrcfkrys rsslnrqqdl
      241 shcppppqlr lldflqkrke rkagqhydlk iskagncvdm wkrspcnlai psevdvekya
      301 kveksiksdd sqptvwpahd vkddyvfece agtqyqktkl tilqslgdpl yygkiqpcka
      361 deesdsqmsp shsstddhsn wfiigsktda ervvnqyqel vqneakcpvk mshsssgsas
      421 lsqvspgket dqtetvsvqs svlgkgvkhr pppiklpsss gnsssgnyft pqqtssflks
      481 ptpppsskps siprkssvdl nqvsmlspaa lspasssqrt tatqvmansa glnfinvvgs
      541 vcgaqalmsg snpmlgcntg aitpaginls gllpsggllp nalpsamqaa sqagvpfglk
      601 ntsslrplnl lqqqqqqlsq ftpqqpqqpt tcspqqpgeq gseqgstsqe qalsaqqaav
      661 inltgvgsfm qsqaavlsql gsaenrpeqs lpqqrfqlss afqqqqqqiq qlrflqhqma
      721 maaaaaqtaq lhhhrhtgsq skskmkrgtp ttpkf
//
LOCUS       XP_005266522             732 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor SPT20 homolog isoform X25 [Homo sapiens].
ACCESSION   XP_005266522
VERSION     XP_005266522.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266465.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..732
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..732
                     /product="transcription factor SPT20 homolog isoform X25"
                     /calculated_mol_wt=79843
     Region          76..213
                     /region_name="Spt20"
                     /note="Spt20 family; pfam12090"
                     /db_xref="CDD:463459"
     CDS             1..732
                     /gene="SUPT20H"
                     /gene_synonym="C13; C13orf19; FAM48A; FP757; P38IP; SPT20"
                     /coded_by="XM_005266465.4:224..2422"
                     /db_xref="GeneID:55578"
                     /db_xref="HGNC:HGNC:20596"
                     /db_xref="MIM:613417"
ORIGIN      
        1 mqqalelald raeyviesar qrppkrkyls sgrksvfqkl ydlyieecek epevkklrrn
       61 vnlleklvmq etlsclvvnl ypgnegyslm lrgkngsdse tirlpyeege lleyldaeel
      121 ppilvdllek sqvnifhcgc viaeirdyrq ssnmkspgyq srhillrptm qtlicdvhsi
      181 tsdnhkwtqe dklllesqli lataeplcld psiavtctan rllynkqkmn trpmkrcfkr
      241 ysrsslnrqq dlshcppppq lrlldflqkr kerkagqhyd lkiskagncv dmwkrspcnl
      301 aipsevdvek yakveksiks ddsqptvwpa hdvkddyvfe ceagtqyqkt kltilqslgd
      361 plyygkiqpc kadeesdsqm spshsstddh snwfiigskt daervvnqyq elvqneakcp
      421 vkmshsssgs aslsqvspgk etdqtetvsv qssvlgkgvk hrpppiklps ssgnsssgny
      481 ftpqqtssfl ksptpppssk pssiprkssv dlnqvsmlsp aalspasssq rttatqvman
      541 saglnfinvv gsvcgaqalm sgsnpmlgcn tgaitpagin lsgllpsggl lpnalpsamq
      601 aasqagvpfg lkntsslrpl nllqlpggsl ifntlqqqqq qlsqftpqqp qqpttcspqq
      661 pgeqgseqgs tsqeqalsaq qaavinltgv gsfmqsqaaa vailaasngy gsssstnssa
      721 tsssayrqpv kk
//
LOCUS       XP_047286418             732 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor SPT20 homolog isoform X25 [Homo sapiens].
ACCESSION   XP_047286418
VERSION     XP_047286418.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430462.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..732
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..732
                     /product="transcription factor SPT20 homolog isoform X25"
                     /calculated_mol_wt=79843
     Region          76..213
                     /region_name="Spt20"
                     /note="Spt20 family; pfam12090"
                     /db_xref="CDD:463459"
     CDS             1..732
                     /gene="SUPT20H"
                     /gene_synonym="C13; C13orf19; FAM48A; FP757; P38IP; SPT20"
                     /coded_by="XM_047430462.1:303..2501"
                     /db_xref="GeneID:55578"
                     /db_xref="HGNC:HGNC:20596"
                     /db_xref="MIM:613417"
ORIGIN      
        1 mqqalelald raeyviesar qrppkrkyls sgrksvfqkl ydlyieecek epevkklrrn
       61 vnlleklvmq etlsclvvnl ypgnegyslm lrgkngsdse tirlpyeege lleyldaeel
      121 ppilvdllek sqvnifhcgc viaeirdyrq ssnmkspgyq srhillrptm qtlicdvhsi
      181 tsdnhkwtqe dklllesqli lataeplcld psiavtctan rllynkqkmn trpmkrcfkr
      241 ysrsslnrqq dlshcppppq lrlldflqkr kerkagqhyd lkiskagncv dmwkrspcnl
      301 aipsevdvek yakveksiks ddsqptvwpa hdvkddyvfe ceagtqyqkt kltilqslgd
      361 plyygkiqpc kadeesdsqm spshsstddh snwfiigskt daervvnqyq elvqneakcp
      421 vkmshsssgs aslsqvspgk etdqtetvsv qssvlgkgvk hrpppiklps ssgnsssgny
      481 ftpqqtssfl ksptpppssk pssiprkssv dlnqvsmlsp aalspasssq rttatqvman
      541 saglnfinvv gsvcgaqalm sgsnpmlgcn tgaitpagin lsgllpsggl lpnalpsamq
      601 aasqagvpfg lkntsslrpl nllqlpggsl ifntlqqqqq qlsqftpqqp qqpttcspqq
      661 pgeqgseqgs tsqeqalsaq qaavinltgv gsfmqsqaaa vailaasngy gsssstnssa
      721 tsssayrqpv kk
//
LOCUS       XP_016876147             721 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor SPT20 homolog isoform X26 [Homo sapiens].
ACCESSION   XP_016876147
VERSION     XP_016876147.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020658.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..721
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..721
                     /product="transcription factor SPT20 homolog isoform X26"
                     /calculated_mol_wt=78632
     Region          65..202
                     /region_name="Spt20"
                     /note="Spt20 family; pfam12090"
                     /db_xref="CDD:463459"
     CDS             1..721
                     /gene="SUPT20H"
                     /gene_synonym="C13; C13orf19; FAM48A; FP757; P38IP; SPT20"
                     /coded_by="XM_017020658.2:224..2389"
                     /db_xref="GeneID:55578"
                     /db_xref="HGNC:HGNC:20596"
                     /db_xref="MIM:613417"
ORIGIN      
        1 myviesarqr ppkrkylssg rksvfqklyd lyieecekep evkqklrrnv nlleklvmqe
       61 tlsclvvnly pgnegyslml rgkngsdset irlpyeegel leyldaeelp pilvdlleks
      121 qvnifhcgcv iaeirdyrqs snmkspgyqs rhillrptmq tlicdvhsit sdnhkwtqed
      181 klllesqlil ataeplcldp siavtctanr llynkqkmnt rpmkrcfkry srsslnrqqd
      241 lshcppppql rlldflqkrk erkagqhydl kiskagncvd mwkrspcnla ipsevdveky
      301 akveksiksd dsqptvwpah dvkddyvfec eagtqyqktk ltilqslgdp lyygkiqpck
      361 adeesdsqms pshsstddhs nwfiigsktd aervvnqyqe lvqneakcpv kmshsssgsa
      421 slsqvspgke tdqtetvsvq ssvlgkgvkh rpppiklpss sgnsssgnyf tpqqtssflk
      481 sptpppsskp ssiprkssvd lnqvsmlspa alspasssqr ttatqvmans aglnfinvvg
      541 svcgaqalms gsnpmlgcnt gaitpaginl sgllpsggll pnalpsamqa asqagvpfgl
      601 kntsslrpln llqlpggsli fntlqqqqqq lsqftpqqpq qpttcspqqp geqgseqgst
      661 sqeqalsaqq aavinltgvg sfmqsqaaav ailaasngyg sssstnssat sssayrqpvk
      721 k
//
LOCUS       XP_005266524             721 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor SPT20 homolog isoform X27 [Homo sapiens].
ACCESSION   XP_005266524
VERSION     XP_005266524.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266467.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..721
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..721
                     /product="transcription factor SPT20 homolog isoform X27"
                     /calculated_mol_wt=78729
     Region          77..214
                     /region_name="Spt20"
                     /note="Spt20 family; pfam12090"
                     /db_xref="CDD:463459"
     CDS             1..721
                     /gene="SUPT20H"
                     /gene_synonym="C13; C13orf19; FAM48A; FP757; P38IP; SPT20"
                     /coded_by="XM_005266467.4:224..2389"
                     /db_xref="GeneID:55578"
                     /db_xref="HGNC:HGNC:20596"
                     /db_xref="MIM:613417"
ORIGIN      
        1 mqqalelald raeyviesar qrppkrkyls sgrksvfqkl ydlyieecek epevkqklrr
       61 nvnlleklvm qetlsclvvn lypgnegysl mlrgkngsds etirlpyeeg elleyldaee
      121 lppilvdlle ksqvnifhcg cviaeirdyr qssnmkspgy qsrhillrpt mqtlicdvhs
      181 itsdnhkwtq edklllesql ilataeplcl dpsiavtcta nrllynkqkm ntrpmkrcfk
      241 rysrsslnrq qdlshcpppp qlrlldflqk rkerkagqhy dlkiskagnc vdmwkrspcn
      301 laipsevdve kyakveksik sddsqptvwp ahdvkddyvf eceagtqyqk tkltilqslg
      361 dplyygkiqp ckadeesdsq mspshsstdd hsnwfiigsk tdaervvnqy qelvqneakc
      421 pvkmshsssg saslsqvspg ketdqtetvs vqssvlgkgv khrpppiklp sssgnsssgn
      481 yftpqqtssf lksptpppss kpssiprkss vdlnqvsmls paalspasss qrttatqvma
      541 nsaglnfinv vgsvcgaqal msgsnpmlgc ntgaitpagi nlsgllpsgg llpnalpsam
      601 qaasqagvpf glkntsslrp lnllqqqqqq lsqftpqqpq qpttcspqqp geqgseqgst
      661 sqeqalsaqq aavinltgvg sfmqsqaaav ailaasngyg sssstnssat sssayrqpvk
      721 k
//
LOCUS       XP_016876148             720 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor SPT20 homolog isoform X28 [Homo sapiens].
ACCESSION   XP_016876148
VERSION     XP_016876148.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020659.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..720
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..720
                     /product="transcription factor SPT20 homolog isoform X28"
                     /calculated_mol_wt=78504
     Region          64..201
                     /region_name="Spt20"
                     /note="Spt20 family; pfam12090"
                     /db_xref="CDD:463459"
     CDS             1..720
                     /gene="SUPT20H"
                     /gene_synonym="C13; C13orf19; FAM48A; FP757; P38IP; SPT20"
                     /coded_by="XM_017020659.2:224..2386"
                     /db_xref="GeneID:55578"
                     /db_xref="HGNC:HGNC:20596"
                     /db_xref="MIM:613417"
ORIGIN      
        1 myviesarqr ppkrkylssg rksvfqklyd lyieecekep evkklrrnvn lleklvmqet
       61 lsclvvnlyp gnegyslmlr gkngsdseti rlpyeegell eyldaeelpp ilvdlleksq
      121 vnifhcgcvi aeirdyrqss nmkspgyqsr hillrptmqt licdvhsits dnhkwtqedk
      181 lllesqlila taeplcldps iavtctanrl lynkqkmntr pmkrcfkrys rsslnrqqdl
      241 shcppppqlr lldflqkrke rkagqhydlk iskagncvdm wkrspcnlai psevdvekya
      301 kveksiksdd sqptvwpahd vkddyvfece agtqyqktkl tilqslgdpl yygkiqpcka
      361 deesdsqmsp shsstddhsn wfiigsktda ervvnqyqel vqneakcpvk mshsssgsas
      421 lsqvspgket dqtetvsvqs svlgkgvkhr pppiklpsss gnsssgnyft pqqtssflks
      481 ptpppsskps siprkssvdl nqvsmlspaa lspasssqrt tatqvmansa glnfinvvgs
      541 vcgaqalmsg snpmlgcntg aitpaginls gllpsggllp nalpsamqaa sqagvpfglk
      601 ntsslrplnl lqlpggslif ntlqqqqqql sqftpqqpqq pttcspqqpg eqgseqgsts
      661 qeqalsaqqa avinltgvgs fmqsqaaava ilaasngygs ssstnssats ssayrqpvkk
//
LOCUS       XP_016876149             720 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor SPT20 homolog isoform X29 [Homo sapiens].
ACCESSION   XP_016876149
VERSION     XP_016876149.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020660.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..720
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..720
                     /product="transcription factor SPT20 homolog isoform X29"
                     /calculated_mol_wt=78601
     Region          76..213
                     /region_name="Spt20"
                     /note="Spt20 family; pfam12090"
                     /db_xref="CDD:463459"
     CDS             1..720
                     /gene="SUPT20H"
                     /gene_synonym="C13; C13orf19; FAM48A; FP757; P38IP; SPT20"
                     /coded_by="XM_017020660.3:224..2386"
                     /db_xref="GeneID:55578"
                     /db_xref="HGNC:HGNC:20596"
                     /db_xref="MIM:613417"
ORIGIN      
        1 mqqalelald raeyviesar qrppkrkyls sgrksvfqkl ydlyieecek epevkklrrn
       61 vnlleklvmq etlsclvvnl ypgnegyslm lrgkngsdse tirlpyeege lleyldaeel
      121 ppilvdllek sqvnifhcgc viaeirdyrq ssnmkspgyq srhillrptm qtlicdvhsi
      181 tsdnhkwtqe dklllesqli lataeplcld psiavtctan rllynkqkmn trpmkrcfkr
      241 ysrsslnrqq dlshcppppq lrlldflqkr kerkagqhyd lkiskagncv dmwkrspcnl
      301 aipsevdvek yakveksiks ddsqptvwpa hdvkddyvfe ceagtqyqkt kltilqslgd
      361 plyygkiqpc kadeesdsqm spshsstddh snwfiigskt daervvnqyq elvqneakcp
      421 vkmshsssgs aslsqvspgk etdqtetvsv qssvlgkgvk hrpppiklps ssgnsssgny
      481 ftpqqtssfl ksptpppssk pssiprkssv dlnqvsmlsp aalspasssq rttatqvman
      541 saglnfinvv gsvcgaqalm sgsnpmlgcn tgaitpagin lsgllpsggl lpnalpsamq
      601 aasqagvpfg lkntsslrpl nllqqqqqql sqftpqqpqq pttcspqqpg eqgseqgsts
      661 qeqalsaqqa avinltgvgs fmqsqaaava ilaasngygs ssstnssats ssayrqpvkk
//
LOCUS       XP_047286419             720 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor SPT20 homolog isoform X29 [Homo sapiens].
ACCESSION   XP_047286419
VERSION     XP_047286419.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430463.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..720
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..720
                     /product="transcription factor SPT20 homolog isoform X29"
                     /calculated_mol_wt=78601
     Region          76..213
                     /region_name="Spt20"
                     /note="Spt20 family; pfam12090"
                     /db_xref="CDD:463459"
     CDS             1..720
                     /gene="SUPT20H"
                     /gene_synonym="C13; C13orf19; FAM48A; FP757; P38IP; SPT20"
                     /coded_by="XM_047430463.1:303..2465"
                     /db_xref="GeneID:55578"
                     /db_xref="HGNC:HGNC:20596"
                     /db_xref="MIM:613417"
ORIGIN      
        1 mqqalelald raeyviesar qrppkrkyls sgrksvfqkl ydlyieecek epevkklrrn
       61 vnlleklvmq etlsclvvnl ypgnegyslm lrgkngsdse tirlpyeege lleyldaeel
      121 ppilvdllek sqvnifhcgc viaeirdyrq ssnmkspgyq srhillrptm qtlicdvhsi
      181 tsdnhkwtqe dklllesqli lataeplcld psiavtctan rllynkqkmn trpmkrcfkr
      241 ysrsslnrqq dlshcppppq lrlldflqkr kerkagqhyd lkiskagncv dmwkrspcnl
      301 aipsevdvek yakveksiks ddsqptvwpa hdvkddyvfe ceagtqyqkt kltilqslgd
      361 plyygkiqpc kadeesdsqm spshsstddh snwfiigskt daervvnqyq elvqneakcp
      421 vkmshsssgs aslsqvspgk etdqtetvsv qssvlgkgvk hrpppiklps ssgnsssgny
      481 ftpqqtssfl ksptpppssk pssiprkssv dlnqvsmlsp aalspasssq rttatqvman
      541 saglnfinvv gsvcgaqalm sgsnpmlgcn tgaitpagin lsgllpsggl lpnalpsamq
      601 aasqagvpfg lkntsslrpl nllqqqqqql sqftpqqpqq pttcspqqpg eqgseqgsts
      661 qeqalsaqqa avinltgvgs fmqsqaaava ilaasngygs ssstnssats ssayrqpvkk
//
LOCUS       XP_047286420             709 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor SPT20 homolog isoform X30 [Homo sapiens].
ACCESSION   XP_047286420
VERSION     XP_047286420.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430464.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..709
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..709
                     /product="transcription factor SPT20 homolog isoform X30"
                     /calculated_mol_wt=77391
     Region          65..202
                     /region_name="Spt20"
                     /note="Spt20 family; pfam12090"
                     /db_xref="CDD:463459"
     CDS             1..709
                     /gene="SUPT20H"
                     /gene_synonym="C13; C13orf19; FAM48A; FP757; P38IP; SPT20"
                     /coded_by="XM_047430464.1:224..2353"
                     /db_xref="GeneID:55578"
                     /db_xref="HGNC:HGNC:20596"
                     /db_xref="MIM:613417"
ORIGIN      
        1 myviesarqr ppkrkylssg rksvfqklyd lyieecekep evkqklrrnv nlleklvmqe
       61 tlsclvvnly pgnegyslml rgkngsdset irlpyeegel leyldaeelp pilvdlleks
      121 qvnifhcgcv iaeirdyrqs snmkspgyqs rhillrptmq tlicdvhsit sdnhkwtqed
      181 klllesqlil ataeplcldp siavtctanr llynkqkmnt rpmkrcfkry srsslnrqqd
      241 lshcppppql rlldflqkrk erkagqhydl kiskagncvd mwkrspcnla ipsevdveky
      301 akveksiksd dsqptvwpah dvkddyvfec eagtqyqktk ltilqslgdp lyygkiqpck
      361 adeesdsqms pshsstddhs nwfiigsktd aervvnqyqe lvqneakcpv kmshsssgsa
      421 slsqvspgke tdqtetvsvq ssvlgkgvkh rpppiklpss sgnsssgnyf tpqqtssflk
      481 sptpppsskp ssiprkssvd lnqvsmlspa alspasssqr ttatqvmans aglnfinvvg
      541 svcgaqalms gsnpmlgcnt gaitpaginl sgllpsggll pnalpsamqa asqagvpfgl
      601 kntsslrpln llqqqqqqls qftpqqpqqp ttcspqqpge qgseqgstsq eqalsaqqaa
      661 vinltgvgsf mqsqaaavai laasngygss sstnssatss sayrqpvkk
//
LOCUS       XP_016876150             708 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor SPT20 homolog isoform X31 [Homo sapiens].
ACCESSION   XP_016876150
VERSION     XP_016876150.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020661.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..708
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..708
                     /product="transcription factor SPT20 homolog isoform X31"
                     /calculated_mol_wt=77263
     Region          64..201
                     /region_name="Spt20"
                     /note="Spt20 family; pfam12090"
                     /db_xref="CDD:463459"
     CDS             1..708
                     /gene="SUPT20H"
                     /gene_synonym="C13; C13orf19; FAM48A; FP757; P38IP; SPT20"
                     /coded_by="XM_017020661.2:224..2350"
                     /db_xref="GeneID:55578"
                     /db_xref="HGNC:HGNC:20596"
                     /db_xref="MIM:613417"
ORIGIN      
        1 myviesarqr ppkrkylssg rksvfqklyd lyieecekep evkklrrnvn lleklvmqet
       61 lsclvvnlyp gnegyslmlr gkngsdseti rlpyeegell eyldaeelpp ilvdlleksq
      121 vnifhcgcvi aeirdyrqss nmkspgyqsr hillrptmqt licdvhsits dnhkwtqedk
      181 lllesqlila taeplcldps iavtctanrl lynkqkmntr pmkrcfkrys rsslnrqqdl
      241 shcppppqlr lldflqkrke rkagqhydlk iskagncvdm wkrspcnlai psevdvekya
      301 kveksiksdd sqptvwpahd vkddyvfece agtqyqktkl tilqslgdpl yygkiqpcka
      361 deesdsqmsp shsstddhsn wfiigsktda ervvnqyqel vqneakcpvk mshsssgsas
      421 lsqvspgket dqtetvsvqs svlgkgvkhr pppiklpsss gnsssgnyft pqqtssflks
      481 ptpppsskps siprkssvdl nqvsmlspaa lspasssqrt tatqvmansa glnfinvvgs
      541 vcgaqalmsg snpmlgcntg aitpaginls gllpsggllp nalpsamqaa sqagvpfglk
      601 ntsslrplnl lqqqqqqlsq ftpqqpqqpt tcspqqpgeq gseqgstsqe qalsaqqaav
      661 inltgvgsfm qsqaaavail aasngygsss stnssatsss ayrqpvkk
//
LOCUS       XP_047286421             535 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor SPT20 homolog isoform X32 [Homo sapiens].
ACCESSION   XP_047286421
VERSION     XP_047286421.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430465.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..535
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..535
                     /product="transcription factor SPT20 homolog isoform X32"
                     /calculated_mol_wt=60117
     Region          77..214
                     /region_name="Spt20"
                     /note="Spt20 family; pfam12090"
                     /db_xref="CDD:463459"
     CDS             1..535
                     /gene="SUPT20H"
                     /gene_synonym="C13; C13orf19; FAM48A; FP757; P38IP; SPT20"
                     /coded_by="XM_047430465.1:224..1831"
                     /db_xref="GeneID:55578"
                     /db_xref="HGNC:HGNC:20596"
                     /db_xref="MIM:613417"
ORIGIN      
        1 mqqalelald raeyviesar qrppkrkyls sgrksvfqkl ydlyieecek epevkqklrr
       61 nvnlleklvm qetlsclvvn lypgnegysl mlrgkngsds etirlpyeeg elleyldaee
      121 lppilvdlle ksqvnifhcg cviaeirdyr qssnmkspgy qsrhillrpt mqtlicdvhs
      181 itsdnhkwtq edklllesql ilataeplcl dpsiavtcta nrllynkqkm ntrpmkrcfk
      241 rysrsslnrq qdlshcpppp qlrlldflqk rkerkagqhy dlkiskagnc vdmwkrspcn
      301 laipsevdve kyakveksik sddsqptvwp ahdvkddyvf eceagtqyqk tkltilqslg
      361 dplyygkiqp ckadeesdsq mspshsstdd hsnwfiigsk tdaervvnqy qelvqneakc
      421 pvkmshsssg saslsqvspg ketdqtetvs vqssvlgkgv khrpppiklp sssgnsssgn
      481 yftpqqtssf lksptpppss kpssiprkss vdlnqvsmls paalspasss qrhes
//
LOCUS       XP_047286422             534 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor SPT20 homolog isoform X33 [Homo sapiens].
ACCESSION   XP_047286422
VERSION     XP_047286422.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430466.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..534
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..534
                     /product="transcription factor SPT20 homolog isoform X33"
                     /calculated_mol_wt=59989
     Region          76..213
                     /region_name="Spt20"
                     /note="Spt20 family; pfam12090"
                     /db_xref="CDD:463459"
     CDS             1..534
                     /gene="SUPT20H"
                     /gene_synonym="C13; C13orf19; FAM48A; FP757; P38IP; SPT20"
                     /coded_by="XM_047430466.1:224..1828"
                     /db_xref="GeneID:55578"
                     /db_xref="HGNC:HGNC:20596"
                     /db_xref="MIM:613417"
ORIGIN      
        1 mqqalelald raeyviesar qrppkrkyls sgrksvfqkl ydlyieecek epevkklrrn
       61 vnlleklvmq etlsclvvnl ypgnegyslm lrgkngsdse tirlpyeege lleyldaeel
      121 ppilvdllek sqvnifhcgc viaeirdyrq ssnmkspgyq srhillrptm qtlicdvhsi
      181 tsdnhkwtqe dklllesqli lataeplcld psiavtctan rllynkqkmn trpmkrcfkr
      241 ysrsslnrqq dlshcppppq lrlldflqkr kerkagqhyd lkiskagncv dmwkrspcnl
      301 aipsevdvek yakveksiks ddsqptvwpa hdvkddyvfe ceagtqyqkt kltilqslgd
      361 plyygkiqpc kadeesdsqm spshsstddh snwfiigskt daervvnqyq elvqneakcp
      421 vkmshsssgs aslsqvspgk etdqtetvsv qssvlgkgvk hrpppiklps ssgnsssgny
      481 ftpqqtssfl ksptpppssk pssiprkssv dlnqvsmlsp aalspasssq rhes
//
LOCUS       XP_047286423             523 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor SPT20 homolog isoform X34 [Homo sapiens].
ACCESSION   XP_047286423
VERSION     XP_047286423.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430467.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..523
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..523
                     /product="transcription factor SPT20 homolog isoform X34"
                     /calculated_mol_wt=58779
     Region          65..202
                     /region_name="Spt20"
                     /note="Spt20 family; pfam12090"
                     /db_xref="CDD:463459"
     CDS             1..523
                     /gene="SUPT20H"
                     /gene_synonym="C13; C13orf19; FAM48A; FP757; P38IP; SPT20"
                     /coded_by="XM_047430467.1:224..1795"
                     /db_xref="GeneID:55578"
                     /db_xref="HGNC:HGNC:20596"
                     /db_xref="MIM:613417"
ORIGIN      
        1 myviesarqr ppkrkylssg rksvfqklyd lyieecekep evkqklrrnv nlleklvmqe
       61 tlsclvvnly pgnegyslml rgkngsdset irlpyeegel leyldaeelp pilvdlleks
      121 qvnifhcgcv iaeirdyrqs snmkspgyqs rhillrptmq tlicdvhsit sdnhkwtqed
      181 klllesqlil ataeplcldp siavtctanr llynkqkmnt rpmkrcfkry srsslnrqqd
      241 lshcppppql rlldflqkrk erkagqhydl kiskagncvd mwkrspcnla ipsevdveky
      301 akveksiksd dsqptvwpah dvkddyvfec eagtqyqktk ltilqslgdp lyygkiqpck
      361 adeesdsqms pshsstddhs nwfiigsktd aervvnqyqe lvqneakcpv kmshsssgsa
      421 slsqvspgke tdqtetvsvq ssvlgkgvkh rpppiklpss sgnsssgnyf tpqqtssflk
      481 sptpppsskp ssiprkssvd lnqvsmlspa alspasssqr hes
//
LOCUS       XP_047286424             522 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor SPT20 homolog isoform X35 [Homo sapiens].
ACCESSION   XP_047286424
VERSION     XP_047286424.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430468.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..522
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..522
                     /product="transcription factor SPT20 homolog isoform X35"
                     /calculated_mol_wt=58651
     Region          64..201
                     /region_name="Spt20"
                     /note="Spt20 family; pfam12090"
                     /db_xref="CDD:463459"
     CDS             1..522
                     /gene="SUPT20H"
                     /gene_synonym="C13; C13orf19; FAM48A; FP757; P38IP; SPT20"
                     /coded_by="XM_047430468.1:224..1792"
                     /db_xref="GeneID:55578"
                     /db_xref="HGNC:HGNC:20596"
                     /db_xref="MIM:613417"
ORIGIN      
        1 myviesarqr ppkrkylssg rksvfqklyd lyieecekep evkklrrnvn lleklvmqet
       61 lsclvvnlyp gnegyslmlr gkngsdseti rlpyeegell eyldaeelpp ilvdlleksq
      121 vnifhcgcvi aeirdyrqss nmkspgyqsr hillrptmqt licdvhsits dnhkwtqedk
      181 lllesqlila taeplcldps iavtctanrl lynkqkmntr pmkrcfkrys rsslnrqqdl
      241 shcppppqlr lldflqkrke rkagqhydlk iskagncvdm wkrspcnlai psevdvekya
      301 kveksiksdd sqptvwpahd vkddyvfece agtqyqktkl tilqslgdpl yygkiqpcka
      361 deesdsqmsp shsstddhsn wfiigsktda ervvnqyqel vqneakcpvk mshsssgsas
      421 lsqvspgket dqtetvsvqs svlgkgvkhr pppiklpsss gnsssgnyft pqqtssflks
      481 ptpppsskps siprkssvdl nqvsmlspaa lspasssqrh es
//
LOCUS       XP_047286425             420 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor SPT20 homolog isoform X36 [Homo sapiens].
ACCESSION   XP_047286425
VERSION     XP_047286425.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430469.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..420
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..420
                     /product="transcription factor SPT20 homolog isoform X36"
                     /calculated_mol_wt=48307
     Region          77..214
                     /region_name="Spt20"
                     /note="Spt20 family; pfam12090"
                     /db_xref="CDD:463459"
     CDS             1..420
                     /gene="SUPT20H"
                     /gene_synonym="C13; C13orf19; FAM48A; FP757; P38IP; SPT20"
                     /coded_by="XM_047430469.1:224..1486"
                     /db_xref="GeneID:55578"
                     /db_xref="HGNC:HGNC:20596"
                     /db_xref="MIM:613417"
ORIGIN      
        1 mqqalelald raeyviesar qrppkrkyls sgrksvfqkl ydlyieecek epevkqklrr
       61 nvnlleklvm qetlsclvvn lypgnegysl mlrgkngsds etirlpyeeg elleyldaee
      121 lppilvdlle ksqvnifhcg cviaeirdyr qssnmkspgy qsrhillrpt mqtlicdvhs
      181 itsdnhkwtq edklllesql ilataeplcl dpsiavtcta nrllynkqkm ntrpmkrcfk
      241 rysrsslnrq qdlshcpppp qlrlldflqk rkerkagqhy dlkiskagnc vdmwkrspcn
      301 laipsevdve kyakveksik sddsqptvwp ahdvkddyvf eceagtqyqk tkltilqslg
      361 dplyygkiqp ckadeesdsq mspshsstdd hsnwfiigsk tdaesklkpc qfslrywgrv
//
LOCUS       XP_047286426             407 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor SPT20 homolog isoform X37 [Homo sapiens].
ACCESSION   XP_047286426
VERSION     XP_047286426.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430470.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..407
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..407
                     /product="transcription factor SPT20 homolog isoform X37"
                     /calculated_mol_wt=46841
     Region          64..201
                     /region_name="Spt20"
                     /note="Spt20 family; pfam12090"
                     /db_xref="CDD:463459"
     CDS             1..407
                     /gene="SUPT20H"
                     /gene_synonym="C13; C13orf19; FAM48A; FP757; P38IP; SPT20"
                     /coded_by="XM_047430470.1:224..1447"
                     /db_xref="GeneID:55578"
                     /db_xref="HGNC:HGNC:20596"
                     /db_xref="MIM:613417"
ORIGIN      
        1 myviesarqr ppkrkylssg rksvfqklyd lyieecekep evkklrrnvn lleklvmqet
       61 lsclvvnlyp gnegyslmlr gkngsdseti rlpyeegell eyldaeelpp ilvdlleksq
      121 vnifhcgcvi aeirdyrqss nmkspgyqsr hillrptmqt licdvhsits dnhkwtqedk
      181 lllesqlila taeplcldps iavtctanrl lynkqkmntr pmkrcfkrys rsslnrqqdl
      241 shcppppqlr lldflqkrke rkagqhydlk iskagncvdm wkrspcnlai psevdvekya
      301 kveksiksdd sqptvwpahd vkddyvfece agtqyqktkl tilqslgdpl yygkiqpcka
      361 deesdsqmsp shsstddhsn wfiigsktda esklkpcqfs lrywgrv
//
LOCUS       XP_024305148             315 aa            linear   PRI 05-AUG-2025
DEFINITION  ankyrin repeat domain-containing protein 10 isoform X1 [Homo
            sapiens].
ACCESSION   XP_024305148
VERSION     XP_024305148.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449380.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..315
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..315
                     /product="ankyrin repeat domain-containing protein 10
                     isoform X1"
                     /calculated_mol_wt=33814
     Region          <25..179
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Site            order(57,59,63..64,67..69,71..72,76,79,89,91,93,97..98,
                     101..103,105..106,110,113,122,124,126,130..131,134..136,
                     138..139,143,146,155)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          57..89
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          91..122
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          124..155
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     CDS             1..315
                     /gene="ANKRD10"
                     /coded_by="XM_024449380.2:136..1083"
                     /db_xref="GeneID:55608"
                     /db_xref="HGNC:HGNC:20265"
ORIGIN      
        1 msaagagagv eagfsseell slrfplhrac rdgdlatlcs llqqtphahl asedsfygwt
       61 pvhwaahfgk leclvqlvra gatlnvsttr yaqtpahiaa fgghpqclvw liqaganink
      121 pdcegetpih kaarsgslec isalvangah vdlrnasglt aadiaqtqgf qecaqfllnl
      181 qnchlnhfyn ngilngghqn vfpnhisvgt nrkrcledse dfgvkkarte aqsldsavpl
      241 tngdteddad kmhvdrefav vtggsgqfpv scnnnpmved tkqqesgsvg pkeieiytvs
      301 amqtpcrcrn qyekq
//
LOCUS       XP_024305149             172 aa            linear   PRI 05-AUG-2025
DEFINITION  ankyrin repeat domain-containing protein 10 isoform X2 [Homo
            sapiens].
ACCESSION   XP_024305149
VERSION     XP_024305149.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449381.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..172
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..172
                     /product="ankyrin repeat domain-containing protein 10
                     isoform X2"
                     /calculated_mol_wt=18208
     Region          <25..>152
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          25..52
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(57,59,63..64,67..69,71..72,76,79,89,91,93,97..98,
                     101..103,105..106,110,113,122,124,126,130..131,134..136,
                     138..139,143,146)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          57..89
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          91..122
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          124..152
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     CDS             1..172
                     /gene="ANKRD10"
                     /coded_by="XM_024449381.2:136..654"
                     /db_xref="GeneID:55608"
                     /db_xref="HGNC:HGNC:20265"
ORIGIN      
        1 msaagagagv eagfsseell slrfplhrac rdgdlatlcs llqqtphahl asedsfygwt
       61 pvhwaahfgk leclvqlvra gatlnvsttr yaqtpahiaa fgghpqclvw liqaganink
      121 pdcegetpih kaarsgslec isalvangah vdyviridli fssnprkgeh si
//
LOCUS       XP_024305150             166 aa            linear   PRI 05-AUG-2025
DEFINITION  ankyrin repeat domain-containing protein 10 isoform X3 [Homo
            sapiens].
ACCESSION   XP_024305150
VERSION     XP_024305150.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449382.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..166
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..166
                     /product="ankyrin repeat domain-containing protein 10
                     isoform X3"
                     /calculated_mol_wt=17592
     Region          <25..>166
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          25..52
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(57,59,63..64,67..69,71..72,76,79,89,91,93,97..98,
                     101..103,105..106,110,113,122,124,126,130..131,134..136,
                     138..139,143,146)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          57..89
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          91..122
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          124..152
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     CDS             1..166
                     /gene="ANKRD10"
                     /coded_by="XM_024449382.2:136..636"
                     /db_xref="GeneID:55608"
                     /db_xref="HGNC:HGNC:20265"
ORIGIN      
        1 msaagagagv eagfsseell slrfplhrac rdgdlatlcs llqqtphahl asedsfygwt
       61 pvhwaahfgk leclvqlvra gatlnvsttr yaqtpahiaa fgghpqclvw liqaganink
      121 pdcegetpih kaarsgslec isalvangah vdnpkkgirv lewlfe
//
LOCUS       XP_024305151             155 aa            linear   PRI 05-AUG-2025
DEFINITION  ankyrin repeat domain-containing protein 10 isoform X4 [Homo
            sapiens].
ACCESSION   XP_024305151
VERSION     XP_024305151.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449383.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..155
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..155
                     /product="ankyrin repeat domain-containing protein 10
                     isoform X4"
                     /calculated_mol_wt=16258
     Region          <25..>153
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          25..52
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(57,59,63..64,67..69,71..72,76,79,89,91,93,97..98,
                     101..103,105..106,110,113,122,124,126,130..131,134..136,
                     138..139,143,146)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          57..89
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          91..122
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          124..153
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     CDS             1..155
                     /gene="ANKRD10"
                     /coded_by="XM_024449383.2:136..603"
                     /db_xref="GeneID:55608"
                     /db_xref="HGNC:HGNC:20265"
ORIGIN      
        1 msaagagagv eagfsseell slrfplhrac rdgdlatlcs llqqtphahl asedsfygwt
       61 pvhwaahfgk leclvqlvra gatlnvsttr yaqtpahiaa fgghpqclvw liqaganink
      121 pdcegetpih kaarsgslec isalvangah velhl
//
LOCUS       XP_011519396            1590 aa            linear   PRI 05-AUG-2025
DEFINITION  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X1 [Homo
            sapiens].
ACCESSION   XP_011519396
VERSION     XP_011519396.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521094.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1590
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1590
                     /product="UDP-glucose:glycoprotein glucosyltransferase 2
                     isoform X1"
                     /calculated_mol_wt=182784
     Region          45..226
                     /region_name="Thioredoxin_12"
                     /note="Thioredoxin-like domain; pfam18400"
                     /db_xref="CDD:465748"
     Region          296..424
                     /region_name="Thioredoxin_13"
                     /note="Thioredoxin-like domain; pfam18401"
                     /db_xref="CDD:465749"
     Region          437..686
                     /region_name="Thioredoxin_14"
                     /note="Thioredoxin-like domain; pfam18402"
                     /db_xref="CDD:465750"
     Region          710..933
                     /region_name="Thioredoxin_15"
                     /note="Thioredoxin-like domain; pfam18403"
                     /db_xref="CDD:465751"
     Region          1121..1226
                     /region_name="UDP-g_GGTase"
                     /note="UDP-glucose:Glycoprotein Glucosyltransferase;
                     pfam06427"
                     /db_xref="CDD:461910"
     Region          1259..1525
                     /region_name="Glyco_transf_24"
                     /note="Glucosyltransferase 24; pfam18404"
                     /db_xref="CDD:436473"
     CDS             1..1590
                     /gene="UGGT2"
                     /gene_synonym="HUGT2; UGCGL2; UGT2"
                     /coded_by="XM_011521094.2:90..4862"
                     /db_xref="GeneID:55757"
                     /db_xref="HGNC:HGNC:15664"
                     /db_xref="MIM:605898"
ORIGIN      
        1 mapakatnvv rlllgstalw lsqlgsgtva asksvtahla akwpetplll easefmaees
       61 nekfwqflet vqelaiykqt esdysyynli lkkagqfldn lhinllkfaf sirayspaiq
      121 mfqqiaadep ppdgcnafvv ihkkhtckin eikkllkkaa srtrpylfkg dhkfptnken
      181 lpvvilyaem gtrtfsafhk vlsekaqnee ilyvlrhyiq kpssrkmyls gygvelaiks
      241 teykalddtq vktvtnttve detetnevqg flfgklkeiy sdlrdnltaf qkyliesnkq
      301 mmplkvwelq dlsfqaasqi msapvydsik lmkdisqnfp ikarsltria vnqhmreeik
      361 enqkdlqvrf kiqpgdarlf inglrvdmdv ydafsildml klegkmmngl rnlgingedm
      421 skflklnshi weytyvldir hssimwindl enddlyitwp tscqkllkpv fpgsvpsirr
      481 nfhnlvlfid paqeytldfi kladvfyshe vplrigfvfi lntddevdga ndagvalwra
      541 fnyiaeefdi seafisivhm yqkvkkdqni ltvdnvksvl qntfphaniw dilgihskyd
      601 eerkagasfy kmtglgplpq alyngepfkh eemnikelkm avlqrmmdas vylqrevflg
      661 tlndrtnaid flmdrnnvvp rintlilrtn qqylnlists vtadvedfst fffldsqdks
      721 aviaknmyyl tqddesiisa vtlwiiadfd kpsgrkllfn alkhmktsvh srlgiiynpt
      781 skineentai srgilaaflt qknmflrsfl gqlakeeiat aiysgdkikt fliegmdkna
      841 fekkyntvgv nifrthqlfc qdvlklrpge mgivsngrfl gpldedfyae dfyllekitf
      901 snlgekikgi venmginann msdfimkvda lmssvpkras rydvtflren hsviktnpqe
      961 ndmffnviai vdpltreaqk maqllvvlgk iinmkiklfm ncrgrlseap leritvihye
     1021 pfllmgifss pscvigqktg fyrfvlepel msgandvssl gpvakfldip espllilnmi
     1081 tpegwlvetv hsncdldnih lkdtektvta eyeleyllle gqcfdkvteq pprglqftlg
     1141 tknkpavvdt ivmahhgyfq lkanpgawil rlhqgksedi yqivghegtd sqadlediiv
     1201 vlnsfkskil kvkvkketdk ikediltded ektkglwdsi ksftvslhke nkkekdvlni
     1261 fsvasghlye rflrimmlsv lrntktpvkf wllknylspt fkeviphmak eygfryelvq
     1321 yrwprwlrqq terqriiwgy kilfldvlfp lavdkiifvd adqivrhdlk elrdfdldga
     1381 pygytpfcds rremdgyrfw ktgywashll rrkyhisaly vvdlkkfrri gagdrlrsqy
     1441 qalsqdpnsl snldqdlpnn miyqvaiksl pqdwlwcetw cddeskqrak tidlcnnpkt
     1501 kesklkaaar ivpewveyda eirqlldhle nkkqdtsstr smaasasgea srsfyswwka
     1561 kqeqvsyigg tgprerrgrc htllnnqish
//
LOCUS       XP_011519397            1563 aa            linear   PRI 05-AUG-2025
DEFINITION  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X2 [Homo
            sapiens].
ACCESSION   XP_011519397
VERSION     XP_011519397.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521095.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1563
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1563
                     /product="UDP-glucose:glycoprotein glucosyltransferase 2
                     isoform X2"
                     /calculated_mol_wt=179795
     Region          45..226
                     /region_name="Thioredoxin_12"
                     /note="Thioredoxin-like domain; pfam18400"
                     /db_xref="CDD:465748"
     Region          296..424
                     /region_name="Thioredoxin_13"
                     /note="Thioredoxin-like domain; pfam18401"
                     /db_xref="CDD:465749"
     Region          437..686
                     /region_name="Thioredoxin_14"
                     /note="Thioredoxin-like domain; pfam18402"
                     /db_xref="CDD:465750"
     Region          710..933
                     /region_name="Thioredoxin_15"
                     /note="Thioredoxin-like domain; pfam18403"
                     /db_xref="CDD:465751"
     Region          1094..1199
                     /region_name="UDP-g_GGTase"
                     /note="UDP-glucose:Glycoprotein Glucosyltransferase;
                     pfam06427"
                     /db_xref="CDD:461910"
     Region          1232..1498
                     /region_name="Glyco_transf_24"
                     /note="Glucosyltransferase 24; pfam18404"
                     /db_xref="CDD:436473"
     CDS             1..1563
                     /gene="UGGT2"
                     /gene_synonym="HUGT2; UGCGL2; UGT2"
                     /coded_by="XM_011521095.2:90..4781"
                     /db_xref="GeneID:55757"
                     /db_xref="HGNC:HGNC:15664"
                     /db_xref="MIM:605898"
ORIGIN      
        1 mapakatnvv rlllgstalw lsqlgsgtva asksvtahla akwpetplll easefmaees
       61 nekfwqflet vqelaiykqt esdysyynli lkkagqfldn lhinllkfaf sirayspaiq
      121 mfqqiaadep ppdgcnafvv ihkkhtckin eikkllkkaa srtrpylfkg dhkfptnken
      181 lpvvilyaem gtrtfsafhk vlsekaqnee ilyvlrhyiq kpssrkmyls gygvelaiks
      241 teykalddtq vktvtnttve detetnevqg flfgklkeiy sdlrdnltaf qkyliesnkq
      301 mmplkvwelq dlsfqaasqi msapvydsik lmkdisqnfp ikarsltria vnqhmreeik
      361 enqkdlqvrf kiqpgdarlf inglrvdmdv ydafsildml klegkmmngl rnlgingedm
      421 skflklnshi weytyvldir hssimwindl enddlyitwp tscqkllkpv fpgsvpsirr
      481 nfhnlvlfid paqeytldfi kladvfyshe vplrigfvfi lntddevdga ndagvalwra
      541 fnyiaeefdi seafisivhm yqkvkkdqni ltvdnvksvl qntfphaniw dilgihskyd
      601 eerkagasfy kmtglgplpq alyngepfkh eemnikelkm avlqrmmdas vylqrevflg
      661 tlndrtnaid flmdrnnvvp rintlilrtn qqylnlists vtadvedfst fffldsqdks
      721 aviaknmyyl tqddesiisa vtlwiiadfd kpsgrkllfn alkhmktsvh srlgiiynpt
      781 skineentai srgilaaflt qknmflrsfl gqlakeeiat aiysgdkikt fliegmdkna
      841 fekkyntvgv nifrthqlfc qdvlklrpge mgivsngrfl gpldedfyae dfyllekitf
      901 snlgekikgi venmginann msdfimkvda lmssvpkras rydvtflren hsviktnpqe
      961 ndmffnviai vdpltreaqk maqllvvlgk iinmkiklfm ncrgrlseap lesfyrfvle
     1021 pelmsgandv sslgpvakfl dipespllil nmitpegwlv etvhsncdld nihlkdtekt
     1081 vtaeyeleyl llegqcfdkv teqpprglqf tlgtknkpav vdtivmahhg yfqlkanpga
     1141 wilrlhqgks ediyqivghe gtdsqadled iivvlnsfks kilkvkvkke tdkikedilt
     1201 dedektkglw dsiksftvsl hkenkkekdv lnifsvasgh lyerflrimm lsvlrntktp
     1261 vkfwllknyl sptfkeviph makeygfrye lvqyrwprwl rqqterqrii wgykilfldv
     1321 lfplavdkii fvdadqivrh dlkelrdfdl dgapygytpf cdsrremdgy rfwktgywas
     1381 hllrrkyhis alyvvdlkkf rrigagdrlr sqyqalsqdp nslsnldqdl pnnmiyqvai
     1441 kslpqdwlwc etwcddeskq raktidlcnn pktkesklka aarivpewve ydaeirqlld
     1501 hlenkkqdts strsmaasas geasrsfysw wkakqeqvsy iggtgprerr grchtllnnq
     1561 ish
//
LOCUS       XP_011519398            1546 aa            linear   PRI 05-AUG-2025
DEFINITION  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X3 [Homo
            sapiens].
ACCESSION   XP_011519398
VERSION     XP_011519398.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521096.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1546
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1546
                     /product="UDP-glucose:glycoprotein glucosyltransferase 2
                     isoform X3"
                     /calculated_mol_wt=177789
     Region          45..226
                     /region_name="Thioredoxin_12"
                     /note="Thioredoxin-like domain; pfam18400"
                     /db_xref="CDD:465748"
     Region          296..424
                     /region_name="Thioredoxin_13"
                     /note="Thioredoxin-like domain; pfam18401"
                     /db_xref="CDD:465749"
     Region          437..686
                     /region_name="Thioredoxin_14"
                     /note="Thioredoxin-like domain; pfam18402"
                     /db_xref="CDD:465750"
     Region          710..889
                     /region_name="Thioredoxin_15"
                     /note="Thioredoxin-like domain; pfam18403"
                     /db_xref="CDD:465751"
     Region          1077..1182
                     /region_name="UDP-g_GGTase"
                     /note="UDP-glucose:Glycoprotein Glucosyltransferase;
                     pfam06427"
                     /db_xref="CDD:461910"
     Region          1215..1481
                     /region_name="Glyco_transf_24"
                     /note="Glucosyltransferase 24; pfam18404"
                     /db_xref="CDD:436473"
     CDS             1..1546
                     /gene="UGGT2"
                     /gene_synonym="HUGT2; UGCGL2; UGT2"
                     /coded_by="XM_011521096.2:90..4730"
                     /db_xref="GeneID:55757"
                     /db_xref="HGNC:HGNC:15664"
                     /db_xref="MIM:605898"
ORIGIN      
        1 mapakatnvv rlllgstalw lsqlgsgtva asksvtahla akwpetplll easefmaees
       61 nekfwqflet vqelaiykqt esdysyynli lkkagqfldn lhinllkfaf sirayspaiq
      121 mfqqiaadep ppdgcnafvv ihkkhtckin eikkllkkaa srtrpylfkg dhkfptnken
      181 lpvvilyaem gtrtfsafhk vlsekaqnee ilyvlrhyiq kpssrkmyls gygvelaiks
      241 teykalddtq vktvtnttve detetnevqg flfgklkeiy sdlrdnltaf qkyliesnkq
      301 mmplkvwelq dlsfqaasqi msapvydsik lmkdisqnfp ikarsltria vnqhmreeik
      361 enqkdlqvrf kiqpgdarlf inglrvdmdv ydafsildml klegkmmngl rnlgingedm
      421 skflklnshi weytyvldir hssimwindl enddlyitwp tscqkllkpv fpgsvpsirr
      481 nfhnlvlfid paqeytldfi kladvfyshe vplrigfvfi lntddevdga ndagvalwra
      541 fnyiaeefdi seafisivhm yqkvkkdqni ltvdnvksvl qntfphaniw dilgihskyd
      601 eerkagasfy kmtglgplpq alyngepfkh eemnikelkm avlqrmmdas vylqrevflg
      661 tlndrtnaid flmdrnnvvp rintlilrtn qqylnlists vtadvedfst fffldsqdks
      721 aviaknmyyl tqddesiisa vtlwiiadfd kpsgrkllfn alkhmktsvh srlgiiynpt
      781 skineentai srgilaaflt qknmflrsfl gqlakeeiat aiysgdkikt flieflgpld
      841 edfyaedfyl lekitfsnlg ekikgivenm ginannmsdf imkvdalmss vpkrasrydv
      901 tflrenhsvi ktnpqendmf fnviaivdpl treaqkmaql lvvlgkiinm kiklfmncrg
      961 rlseapleri tvihyepfll mgifsspscv igqktgfyrf vlepelmsga ndvsslgpva
     1021 kfldipespl lilnmitpeg wlvetvhsnc dldnihlkdt ektvtaeyel eylllegqcf
     1081 dkvteqpprg lqftlgtknk pavvdtivma hhgyfqlkan pgawilrlhq gksediyqiv
     1141 ghegtdsqad lediivvlns fkskilkvkv kketdkiked iltdedektk glwdsiksft
     1201 vslhkenkke kdvlnifsva sghlyerflr immlsvlrnt ktpvkfwllk nylsptfkev
     1261 iphmakeygf ryelvqyrwp rwlrqqterq riiwgykilf ldvlfplavd kiifvdadqi
     1321 vrhdlkelrd fdldgapygy tpfcdsrrem dgyrfwktgy washllrrky hisalyvvdl
     1381 kkfrrigagd rlrsqyqals qdpnslsnld qdlpnnmiyq vaikslpqdw lwcetwcdde
     1441 skqraktidl cnnpktkesk lkaaarivpe wveydaeirq lldhlenkkq dtsstrsmaa
     1501 sasgeasrsf yswwkakqeq vsyiggtgpr errgrchtll nnqish
//
LOCUS       XP_011519399            1543 aa            linear   PRI 05-AUG-2025
DEFINITION  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X4 [Homo
            sapiens].
ACCESSION   XP_011519399
VERSION     XP_011519399.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521097.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1543
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1543
                     /product="UDP-glucose:glycoprotein glucosyltransferase 2
                     isoform X4"
                     /calculated_mol_wt=177595
     Region          45..226
                     /region_name="Thioredoxin_12"
                     /note="Thioredoxin-like domain; pfam18400"
                     /db_xref="CDD:465748"
     Region          296..424
                     /region_name="Thioredoxin_13"
                     /note="Thioredoxin-like domain; pfam18401"
                     /db_xref="CDD:465749"
     Region          437..686
                     /region_name="Thioredoxin_14"
                     /note="Thioredoxin-like domain; pfam18402"
                     /db_xref="CDD:465750"
     Region          710..933
                     /region_name="Thioredoxin_15"
                     /note="Thioredoxin-like domain; pfam18403"
                     /db_xref="CDD:465751"
     Region          1121..1226
                     /region_name="UDP-g_GGTase"
                     /note="UDP-glucose:Glycoprotein Glucosyltransferase;
                     pfam06427"
                     /db_xref="CDD:461910"
     Region          1259..1525
                     /region_name="Glyco_transf_24"
                     /note="Glucosyltransferase 24; pfam18404"
                     /db_xref="CDD:436473"
     CDS             1..1543
                     /gene="UGGT2"
                     /gene_synonym="HUGT2; UGCGL2; UGT2"
                     /coded_by="XM_011521097.2:90..4721"
                     /db_xref="GeneID:55757"
                     /db_xref="HGNC:HGNC:15664"
                     /db_xref="MIM:605898"
ORIGIN      
        1 mapakatnvv rlllgstalw lsqlgsgtva asksvtahla akwpetplll easefmaees
       61 nekfwqflet vqelaiykqt esdysyynli lkkagqfldn lhinllkfaf sirayspaiq
      121 mfqqiaadep ppdgcnafvv ihkkhtckin eikkllkkaa srtrpylfkg dhkfptnken
      181 lpvvilyaem gtrtfsafhk vlsekaqnee ilyvlrhyiq kpssrkmyls gygvelaiks
      241 teykalddtq vktvtnttve detetnevqg flfgklkeiy sdlrdnltaf qkyliesnkq
      301 mmplkvwelq dlsfqaasqi msapvydsik lmkdisqnfp ikarsltria vnqhmreeik
      361 enqkdlqvrf kiqpgdarlf inglrvdmdv ydafsildml klegkmmngl rnlgingedm
      421 skflklnshi weytyvldir hssimwindl enddlyitwp tscqkllkpv fpgsvpsirr
      481 nfhnlvlfid paqeytldfi kladvfyshe vplrigfvfi lntddevdga ndagvalwra
      541 fnyiaeefdi seafisivhm yqkvkkdqni ltvdnvksvl qntfphaniw dilgihskyd
      601 eerkagasfy kmtglgplpq alyngepfkh eemnikelkm avlqrmmdas vylqrevflg
      661 tlndrtnaid flmdrnnvvp rintlilrtn qqylnlists vtadvedfst fffldsqdks
      721 aviaknmyyl tqddesiisa vtlwiiadfd kpsgrkllfn alkhmktsvh srlgiiynpt
      781 skineentai srgilaaflt qknmflrsfl gqlakeeiat aiysgdkikt fliegmdkna
      841 fekkyntvgv nifrthqlfc qdvlklrpge mgivsngrfl gpldedfyae dfyllekitf
      901 snlgekikgi venmginann msdfimkvda lmssvpkras rydvtflren hsviktnpqe
      961 ndmffnviai vdpltreaqk maqllvvlgk iinmkiklfm ncrgrlseap leritvihye
     1021 pfllmgifss pscvigqktg fyrfvlepel msgandvssl gpvakfldip espllilnmi
     1081 tpegwlvetv hsncdldnih lkdtektvta eyeleyllle gqcfdkvteq pprglqftlg
     1141 tknkpavvdt ivmahhgyfq lkanpgawil rlhqgksedi yqivghegtd sqadlediiv
     1201 vlnsfkskil kvkvkketdk ikediltded ektkglwdsi ksftvslhke nkkekdvlni
     1261 fsvasghlye rflrimmlsv lrntktpvkf wllknylspt fkeviphmak eygfryelvq
     1321 yrwprwlrqq terqriiwgy kilfldvlfp lavdkiifvd adqivrhdlk elrdfdldga
     1381 pygytpfcds rremdgyrfw ktgywashll rrkyhisaly vvdlkkfrri gagdrlrsqy
     1441 qalsqdpnsl snldqdlpnn miyqvaiksl pqdwlwcetw cddeskqrak tidlcnnpkt
     1501 kesklkaaar ivpewveyda eirqlldhle nkkqdtilth del
//
LOCUS       XP_016876151            1519 aa            linear   PRI 05-AUG-2025
DEFINITION  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X5 [Homo
            sapiens].
ACCESSION   XP_016876151
VERSION     XP_016876151.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020662.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1519
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1519
                     /product="UDP-glucose:glycoprotein glucosyltransferase 2
                     isoform X5"
                     /calculated_mol_wt=174800
     Region          45..226
                     /region_name="Thioredoxin_12"
                     /note="Thioredoxin-like domain; pfam18400"
                     /db_xref="CDD:465748"
     Region          296..424
                     /region_name="Thioredoxin_13"
                     /note="Thioredoxin-like domain; pfam18401"
                     /db_xref="CDD:465749"
     Region          437..686
                     /region_name="Thioredoxin_14"
                     /note="Thioredoxin-like domain; pfam18402"
                     /db_xref="CDD:465750"
     Region          710..889
                     /region_name="Thioredoxin_15"
                     /note="Thioredoxin-like domain; pfam18403"
                     /db_xref="CDD:465751"
     Region          1050..1155
                     /region_name="UDP-g_GGTase"
                     /note="UDP-glucose:Glycoprotein Glucosyltransferase;
                     pfam06427"
                     /db_xref="CDD:461910"
     Region          1188..1454
                     /region_name="Glyco_transf_24"
                     /note="Glucosyltransferase 24; pfam18404"
                     /db_xref="CDD:436473"
     CDS             1..1519
                     /gene="UGGT2"
                     /gene_synonym="HUGT2; UGCGL2; UGT2"
                     /coded_by="XM_017020662.2:90..4649"
                     /db_xref="GeneID:55757"
                     /db_xref="HGNC:HGNC:15664"
                     /db_xref="MIM:605898"
ORIGIN      
        1 mapakatnvv rlllgstalw lsqlgsgtva asksvtahla akwpetplll easefmaees
       61 nekfwqflet vqelaiykqt esdysyynli lkkagqfldn lhinllkfaf sirayspaiq
      121 mfqqiaadep ppdgcnafvv ihkkhtckin eikkllkkaa srtrpylfkg dhkfptnken
      181 lpvvilyaem gtrtfsafhk vlsekaqnee ilyvlrhyiq kpssrkmyls gygvelaiks
      241 teykalddtq vktvtnttve detetnevqg flfgklkeiy sdlrdnltaf qkyliesnkq
      301 mmplkvwelq dlsfqaasqi msapvydsik lmkdisqnfp ikarsltria vnqhmreeik
      361 enqkdlqvrf kiqpgdarlf inglrvdmdv ydafsildml klegkmmngl rnlgingedm
      421 skflklnshi weytyvldir hssimwindl enddlyitwp tscqkllkpv fpgsvpsirr
      481 nfhnlvlfid paqeytldfi kladvfyshe vplrigfvfi lntddevdga ndagvalwra
      541 fnyiaeefdi seafisivhm yqkvkkdqni ltvdnvksvl qntfphaniw dilgihskyd
      601 eerkagasfy kmtglgplpq alyngepfkh eemnikelkm avlqrmmdas vylqrevflg
      661 tlndrtnaid flmdrnnvvp rintlilrtn qqylnlists vtadvedfst fffldsqdks
      721 aviaknmyyl tqddesiisa vtlwiiadfd kpsgrkllfn alkhmktsvh srlgiiynpt
      781 skineentai srgilaaflt qknmflrsfl gqlakeeiat aiysgdkikt flieflgpld
      841 edfyaedfyl lekitfsnlg ekikgivenm ginannmsdf imkvdalmss vpkrasrydv
      901 tflrenhsvi ktnpqendmf fnviaivdpl treaqkmaql lvvlgkiinm kiklfmncrg
      961 rlseaplesf yrfvlepelm sgandvsslg pvakfldipe spllilnmit pegwlvetvh
     1021 sncdldnihl kdtektvtae yeleyllleg qcfdkvteqp prglqftlgt knkpavvdti
     1081 vmahhgyfql kanpgawilr lhqgksediy qivghegtds qadlediivv lnsfkskilk
     1141 vkvkketdki kediltdede ktkglwdsik sftvslhken kkekdvlnif svasghlyer
     1201 flrimmlsvl rntktpvkfw llknylsptf keviphmake ygfryelvqy rwprwlrqqt
     1261 erqriiwgyk ilfldvlfpl avdkiifvda dqivrhdlke lrdfdldgap ygytpfcdsr
     1321 remdgyrfwk tgywashllr rkyhisalyv vdlkkfrrig agdrlrsqyq alsqdpnsls
     1381 nldqdlpnnm iyqvaikslp qdwlwcetwc ddeskqrakt idlcnnpktk esklkaaari
     1441 vpewveydae irqlldhlen kkqdtsstrs maasasgeas rsfyswwkak qeqvsyiggt
     1501 gprerrgrch tllnnqish
//
LOCUS       XP_047286427            1472 aa            linear   PRI 05-AUG-2025
DEFINITION  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X6 [Homo
            sapiens].
ACCESSION   XP_047286427
VERSION     XP_047286427.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430471.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1472
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1472
                     /product="UDP-glucose:glycoprotein glucosyltransferase 2
                     isoform X6"
                     /calculated_mol_wt=169610
     Region          45..226
                     /region_name="Thioredoxin_12"
                     /note="Thioredoxin-like domain; pfam18400"
                     /db_xref="CDD:465748"
     Region          296..424
                     /region_name="Thioredoxin_13"
                     /note="Thioredoxin-like domain; pfam18401"
                     /db_xref="CDD:465749"
     Region          437..686
                     /region_name="Thioredoxin_14"
                     /note="Thioredoxin-like domain; pfam18402"
                     /db_xref="CDD:465750"
     Region          710..889
                     /region_name="Thioredoxin_15"
                     /note="Thioredoxin-like domain; pfam18403"
                     /db_xref="CDD:465751"
     Region          1050..1155
                     /region_name="UDP-g_GGTase"
                     /note="UDP-glucose:Glycoprotein Glucosyltransferase;
                     pfam06427"
                     /db_xref="CDD:461910"
     Region          1188..1454
                     /region_name="Glyco_transf_24"
                     /note="Glucosyltransferase 24; pfam18404"
                     /db_xref="CDD:436473"
     CDS             1..1472
                     /gene="UGGT2"
                     /gene_synonym="HUGT2; UGCGL2; UGT2"
                     /coded_by="XM_047430471.1:90..4508"
                     /db_xref="GeneID:55757"
                     /db_xref="HGNC:HGNC:15664"
                     /db_xref="MIM:605898"
ORIGIN      
        1 mapakatnvv rlllgstalw lsqlgsgtva asksvtahla akwpetplll easefmaees
       61 nekfwqflet vqelaiykqt esdysyynli lkkagqfldn lhinllkfaf sirayspaiq
      121 mfqqiaadep ppdgcnafvv ihkkhtckin eikkllkkaa srtrpylfkg dhkfptnken
      181 lpvvilyaem gtrtfsafhk vlsekaqnee ilyvlrhyiq kpssrkmyls gygvelaiks
      241 teykalddtq vktvtnttve detetnevqg flfgklkeiy sdlrdnltaf qkyliesnkq
      301 mmplkvwelq dlsfqaasqi msapvydsik lmkdisqnfp ikarsltria vnqhmreeik
      361 enqkdlqvrf kiqpgdarlf inglrvdmdv ydafsildml klegkmmngl rnlgingedm
      421 skflklnshi weytyvldir hssimwindl enddlyitwp tscqkllkpv fpgsvpsirr
      481 nfhnlvlfid paqeytldfi kladvfyshe vplrigfvfi lntddevdga ndagvalwra
      541 fnyiaeefdi seafisivhm yqkvkkdqni ltvdnvksvl qntfphaniw dilgihskyd
      601 eerkagasfy kmtglgplpq alyngepfkh eemnikelkm avlqrmmdas vylqrevflg
      661 tlndrtnaid flmdrnnvvp rintlilrtn qqylnlists vtadvedfst fffldsqdks
      721 aviaknmyyl tqddesiisa vtlwiiadfd kpsgrkllfn alkhmktsvh srlgiiynpt
      781 skineentai srgilaaflt qknmflrsfl gqlakeeiat aiysgdkikt flieflgpld
      841 edfyaedfyl lekitfsnlg ekikgivenm ginannmsdf imkvdalmss vpkrasrydv
      901 tflrenhsvi ktnpqendmf fnviaivdpl treaqkmaql lvvlgkiinm kiklfmncrg
      961 rlseaplesf yrfvlepelm sgandvsslg pvakfldipe spllilnmit pegwlvetvh
     1021 sncdldnihl kdtektvtae yeleyllleg qcfdkvteqp prglqftlgt knkpavvdti
     1081 vmahhgyfql kanpgawilr lhqgksediy qivghegtds qadlediivv lnsfkskilk
     1141 vkvkketdki kediltdede ktkglwdsik sftvslhken kkekdvlnif svasghlyer
     1201 flrimmlsvl rntktpvkfw llknylsptf keviphmake ygfryelvqy rwprwlrqqt
     1261 erqriiwgyk ilfldvlfpl avdkiifvda dqivrhdlke lrdfdldgap ygytpfcdsr
     1321 remdgyrfwk tgywashllr rkyhisalyv vdlkkfrrig agdrlrsqyq alsqdpnsls
     1381 nldqdlpnnm iyqvaikslp qdwlwcetwc ddeskqrakt idlcnnpktk esklkaaari
     1441 vpewveydae irqlldhlen kkqdtilthd el
//
LOCUS       XP_047286428            1290 aa            linear   PRI 05-AUG-2025
DEFINITION  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X7 [Homo
            sapiens].
ACCESSION   XP_047286428
VERSION     XP_047286428.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430472.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1290
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1290
                     /product="UDP-glucose:glycoprotein glucosyltransferase 2
                     isoform X7"
                     /calculated_mol_wt=148693
     Region          3..124
                     /region_name="Thioredoxin_13"
                     /note="Thioredoxin-like domain; pfam18401"
                     /db_xref="CDD:465749"
     Region          137..386
                     /region_name="Thioredoxin_14"
                     /note="Thioredoxin-like domain; pfam18402"
                     /db_xref="CDD:465750"
     Region          410..633
                     /region_name="Thioredoxin_15"
                     /note="Thioredoxin-like domain; pfam18403"
                     /db_xref="CDD:465751"
     Region          821..926
                     /region_name="UDP-g_GGTase"
                     /note="UDP-glucose:Glycoprotein Glucosyltransferase;
                     pfam06427"
                     /db_xref="CDD:461910"
     Region          959..1225
                     /region_name="Glyco_transf_24"
                     /note="Glucosyltransferase 24; pfam18404"
                     /db_xref="CDD:436473"
     CDS             1..1290
                     /gene="UGGT2"
                     /gene_synonym="HUGT2; UGCGL2; UGT2"
                     /coded_by="XM_047430472.1:89..3961"
                     /db_xref="GeneID:55757"
                     /db_xref="HGNC:HGNC:15664"
                     /db_xref="MIM:605898"
ORIGIN      
        1 mmplkvwelq dlsfqaasqi msapvydsik lmkdisqnfp ikarsltria vnqhmreeik
       61 enqkdlqvrf kiqpgdarlf inglrvdmdv ydafsildml klegkmmngl rnlgingedm
      121 skflklnshi weytyvldir hssimwindl enddlyitwp tscqkllkpv fpgsvpsirr
      181 nfhnlvlfid paqeytldfi kladvfyshe vplrigfvfi lntddevdga ndagvalwra
      241 fnyiaeefdi seafisivhm yqkvkkdqni ltvdnvksvl qntfphaniw dilgihskyd
      301 eerkagasfy kmtglgplpq alyngepfkh eemnikelkm avlqrmmdas vylqrevflg
      361 tlndrtnaid flmdrnnvvp rintlilrtn qqylnlists vtadvedfst fffldsqdks
      421 aviaknmyyl tqddesiisa vtlwiiadfd kpsgrkllfn alkhmktsvh srlgiiynpt
      481 skineentai srgilaaflt qknmflrsfl gqlakeeiat aiysgdkikt fliegmdkna
      541 fekkyntvgv nifrthqlfc qdvlklrpge mgivsngrfl gpldedfyae dfyllekitf
      601 snlgekikgi venmginann msdfimkvda lmssvpkras rydvtflren hsviktnpqe
      661 ndmffnviai vdpltreaqk maqllvvlgk iinmkiklfm ncrgrlseap leritvihye
      721 pfllmgifss pscvigqktg fyrfvlepel msgandvssl gpvakfldip espllilnmi
      781 tpegwlvetv hsncdldnih lkdtektvta eyeleyllle gqcfdkvteq pprglqftlg
      841 tknkpavvdt ivmahhgyfq lkanpgawil rlhqgksedi yqivghegtd sqadlediiv
      901 vlnsfkskil kvkvkketdk ikediltded ektkglwdsi ksftvslhke nkkekdvlni
      961 fsvasghlye rflrimmlsv lrntktpvkf wllknylspt fkeviphmak eygfryelvq
     1021 yrwprwlrqq terqriiwgy kilfldvlfp lavdkiifvd adqivrhdlk elrdfdldga
     1081 pygytpfcds rremdgyrfw ktgywashll rrkyhisaly vvdlkkfrri gagdrlrsqy
     1141 qalsqdpnsl snldqdlpnn miyqvaiksl pqdwlwcetw cddeskqrak tidlcnnpkt
     1201 kesklkaaar ivpewveyda eirqlldhle nkkqdtsstr smaasasgea srsfyswwka
     1261 kqeqvsyigg tgprerrgrc htllnnqish
//
LOCUS       XP_047286429            1270 aa            linear   PRI 05-AUG-2025
DEFINITION  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X8 [Homo
            sapiens].
ACCESSION   XP_047286429
VERSION     XP_047286429.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430473.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1270
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1270
                     /product="UDP-glucose:glycoprotein glucosyltransferase 2
                     isoform X8"
                     /calculated_mol_wt=146375
     Region          1..104
                     /region_name="Thioredoxin_13"
                     /note="Thioredoxin-like domain; pfam18401"
                     /db_xref="CDD:465749"
     Region          117..366
                     /region_name="Thioredoxin_14"
                     /note="Thioredoxin-like domain; pfam18402"
                     /db_xref="CDD:465750"
     Region          390..613
                     /region_name="Thioredoxin_15"
                     /note="Thioredoxin-like domain; pfam18403"
                     /db_xref="CDD:465751"
     Region          801..906
                     /region_name="UDP-g_GGTase"
                     /note="UDP-glucose:Glycoprotein Glucosyltransferase;
                     pfam06427"
                     /db_xref="CDD:461910"
     Region          939..1205
                     /region_name="Glyco_transf_24"
                     /note="Glucosyltransferase 24; pfam18404"
                     /db_xref="CDD:436473"
     CDS             1..1270
                     /gene="UGGT2"
                     /gene_synonym="HUGT2; UGCGL2; UGT2"
                     /coded_by="XM_047430473.1:103..3915"
                     /db_xref="GeneID:55757"
                     /db_xref="HGNC:HGNC:15664"
                     /db_xref="MIM:605898"
ORIGIN      
        1 msapvydsik lmkdisqnfp ikarsltria vnqhmreeik enqkdlqvrf kiqpgdarlf
       61 inglrvdmdv ydafsildml klegkmmngl rnlgingedm skflklnshi weytyvldir
      121 hssimwindl enddlyitwp tscqkllkpv fpgsvpsirr nfhnlvlfid paqeytldfi
      181 kladvfyshe vplrigfvfi lntddevdga ndagvalwra fnyiaeefdi seafisivhm
      241 yqkvkkdqni ltvdnvksvl qntfphaniw dilgihskyd eerkagasfy kmtglgplpq
      301 alyngepfkh eemnikelkm avlqrmmdas vylqrevflg tlndrtnaid flmdrnnvvp
      361 rintlilrtn qqylnlists vtadvedfst fffldsqdks aviaknmyyl tqddesiisa
      421 vtlwiiadfd kpsgrkllfn alkhmktsvh srlgiiynpt skineentai srgilaaflt
      481 qknmflrsfl gqlakeeiat aiysgdkikt fliegmdkna fekkyntvgv nifrthqlfc
      541 qdvlklrpge mgivsngrfl gpldedfyae dfyllekitf snlgekikgi venmginann
      601 msdfimkvda lmssvpkras rydvtflren hsviktnpqe ndmffnviai vdpltreaqk
      661 maqllvvlgk iinmkiklfm ncrgrlseap leritvihye pfllmgifss pscvigqktg
      721 fyrfvlepel msgandvssl gpvakfldip espllilnmi tpegwlvetv hsncdldnih
      781 lkdtektvta eyeleyllle gqcfdkvteq pprglqftlg tknkpavvdt ivmahhgyfq
      841 lkanpgawil rlhqgksedi yqivghegtd sqadlediiv vlnsfkskil kvkvkketdk
      901 ikediltded ektkglwdsi ksftvslhke nkkekdvlni fsvasghlye rflrimmlsv
      961 lrntktpvkf wllknylspt fkeviphmak eygfryelvq yrwprwlrqq terqriiwgy
     1021 kilfldvlfp lavdkiifvd adqivrhdlk elrdfdldga pygytpfcds rremdgyrfw
     1081 ktgywashll rrkyhisaly vvdlkkfrri gagdrlrsqy qalsqdpnsl snldqdlpnn
     1141 miyqvaiksl pqdwlwcetw cddeskqrak tidlcnnpkt kesklkaaar ivpewveyda
     1201 eirqlldhle nkkqdtsstr smaasasgea srsfyswwka kqeqvsyigg tgprerrgrc
     1261 htllnnqish
//
LOCUS       XP_011519401            1236 aa            linear   PRI 05-AUG-2025
DEFINITION  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X9 [Homo
            sapiens].
ACCESSION   XP_011519401
VERSION     XP_011519401.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521099.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1236
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1236
                     /product="UDP-glucose:glycoprotein glucosyltransferase 2
                     isoform X9"
                     /calculated_mol_wt=142520
     Region          <1..70
                     /region_name="Thioredoxin_13"
                     /note="Thioredoxin-like domain; pfam18401"
                     /db_xref="CDD:465749"
     Region          83..332
                     /region_name="Thioredoxin_14"
                     /note="Thioredoxin-like domain; pfam18402"
                     /db_xref="CDD:465750"
     Region          356..579
                     /region_name="Thioredoxin_15"
                     /note="Thioredoxin-like domain; pfam18403"
                     /db_xref="CDD:465751"
     Region          767..872
                     /region_name="UDP-g_GGTase"
                     /note="UDP-glucose:Glycoprotein Glucosyltransferase;
                     pfam06427"
                     /db_xref="CDD:461910"
     Region          905..1171
                     /region_name="Glyco_transf_24"
                     /note="Glucosyltransferase 24; pfam18404"
                     /db_xref="CDD:436473"
     CDS             1..1236
                     /gene="UGGT2"
                     /gene_synonym="HUGT2; UGCGL2; UGT2"
                     /coded_by="XM_011521099.3:122..3832"
                     /db_xref="GeneID:55757"
                     /db_xref="HGNC:HGNC:15664"
                     /db_xref="MIM:605898"
ORIGIN      
        1 mreeikenqk dlqvrfkiqp gdarlfingl rvdmdvydaf sildmlkleg kmmnglrnlg
       61 ingedmskfl klnshiweyt yvldirhssi mwindlendd lyitwptscq kllkpvfpgs
      121 vpsirrnfhn lvlfidpaqe ytldfiklad vfyshevplr igfvfilntd devdgandag
      181 valwrafnyi aeefdiseaf isivhmyqkv kkdqniltvd nvksvlqntf phaniwdilg
      241 ihskydeerk agasfykmtg lgplpqalyn gepfkheemn ikelkmavlq rmmdasvylq
      301 revflgtlnd rtnaidflmd rnnvvprint lilrtnqqyl nlistsvtad vedfstfffl
      361 dsqdksavia knmyyltqdd esiisavtlw iiadfdkpsg rkllfnalkh mktsvhsrlg
      421 iiynptskin eentaisrgi laafltqknm flrsflgqla keeiataiys gdkiktflie
      481 gmdknafekk yntvgvnifr thqlfcqdvl klrpgemgiv sngrflgpld edfyaedfyl
      541 lekitfsnlg ekikgivenm ginannmsdf imkvdalmss vpkrasrydv tflrenhsvi
      601 ktnpqendmf fnviaivdpl treaqkmaql lvvlgkiinm kiklfmncrg rlseapleri
      661 tvihyepfll mgifsspscv igqktgfyrf vlepelmsga ndvsslgpva kfldipespl
      721 lilnmitpeg wlvetvhsnc dldnihlkdt ektvtaeyel eylllegqcf dkvteqpprg
      781 lqftlgtknk pavvdtivma hhgyfqlkan pgawilrlhq gksediyqiv ghegtdsqad
      841 lediivvlns fkskilkvkv kketdkiked iltdedektk glwdsiksft vslhkenkke
      901 kdvlnifsva sghlyerflr immlsvlrnt ktpvkfwllk nylsptfkev iphmakeygf
      961 ryelvqyrwp rwlrqqterq riiwgykilf ldvlfplavd kiifvdadqi vrhdlkelrd
     1021 fdldgapygy tpfcdsrrem dgyrfwktgy washllrrky hisalyvvdl kkfrrigagd
     1081 rlrsqyqals qdpnslsnld qdlpnnmiyq vaikslpqdw lwcetwcdde skqraktidl
     1141 cnnpktkesk lkaaarivpe wveydaeirq lldhlenkkq dtsstrsmaa sasgeasrsf
     1201 yswwkakqeq vsyiggtgpr errgrchtll nnqish
//
LOCUS       XP_047286430            1203 aa            linear   PRI 05-AUG-2025
DEFINITION  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X10 [Homo
            sapiens].
ACCESSION   XP_047286430
VERSION     XP_047286430.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430474.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1203
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1203
                     /product="UDP-glucose:glycoprotein glucosyltransferase 2
                     isoform X10"
                     /calculated_mol_wt=138580
     Region          <5..37
                     /region_name="Thioredoxin_13"
                     /note="Thioredoxin-like domain; pfam18401"
                     /db_xref="CDD:465749"
     Region          50..299
                     /region_name="Thioredoxin_14"
                     /note="Thioredoxin-like domain; pfam18402"
                     /db_xref="CDD:465750"
     Region          323..546
                     /region_name="Thioredoxin_15"
                     /note="Thioredoxin-like domain; pfam18403"
                     /db_xref="CDD:465751"
     Region          734..839
                     /region_name="UDP-g_GGTase"
                     /note="UDP-glucose:Glycoprotein Glucosyltransferase;
                     pfam06427"
                     /db_xref="CDD:461910"
     Region          872..1138
                     /region_name="Glyco_transf_24"
                     /note="Glucosyltransferase 24; pfam18404"
                     /db_xref="CDD:436473"
     CDS             1..1203
                     /gene="UGGT2"
                     /gene_synonym="HUGT2; UGCGL2; UGT2"
                     /coded_by="XM_047430474.1:130..3741"
                     /db_xref="GeneID:55757"
                     /db_xref="HGNC:HGNC:15664"
                     /db_xref="MIM:605898"
ORIGIN      
        1 mdvydafsil dmlklegkmm nglrnlging edmskflkln shiweytyvl dirhssimwi
       61 ndlenddlyi twptscqkll kpvfpgsvps irrnfhnlvl fidpaqeytl dfikladvfy
      121 shevplrigf vfilntddev dgandagval wrafnyiaee fdiseafisi vhmyqkvkkd
      181 qniltvdnvk svlqntfpha niwdilgihs kydeerkaga sfykmtglgp lpqalyngep
      241 fkheemnike lkmavlqrmm dasvylqrev flgtlndrtn aidflmdrnn vvprintlil
      301 rtnqqylnli stsvtadved fstfffldsq dksaviaknm yyltqddesi isavtlwiia
      361 dfdkpsgrkl lfnalkhmkt svhsrlgiiy nptskineen taisrgilaa fltqknmflr
      421 sflgqlakee iataiysgdk iktfliegmd knafekkynt vgvnifrthq lfcqdvlklr
      481 pgemgivsng rflgpldedf yaedfyllek itfsnlgeki kgivenmgin annmsdfimk
      541 vdalmssvpk rasrydvtfl renhsviktn pqendmffnv iaivdpltre aqkmaqllvv
      601 lgkiinmkik lfmncrgrls eapleritvi hyepfllmgi fsspscvigq ktgfyrfvle
      661 pelmsgandv sslgpvakfl dipespllil nmitpegwlv etvhsncdld nihlkdtekt
      721 vtaeyeleyl llegqcfdkv teqpprglqf tlgtknkpav vdtivmahhg yfqlkanpga
      781 wilrlhqgks ediyqivghe gtdsqadled iivvlnsfks kilkvkvkke tdkikedilt
      841 dedektkglw dsiksftvsl hkenkkekdv lnifsvasgh lyerflrimm lsvlrntktp
      901 vkfwllknyl sptfkeviph makeygfrye lvqyrwprwl rqqterqrii wgykilfldv
      961 lfplavdkii fvdadqivrh dlkelrdfdl dgapygytpf cdsrremdgy rfwktgywas
     1021 hllrrkyhis alyvvdlkkf rrigagdrlr sqyqalsqdp nslsnldqdl pnnmiyqvai
     1081 kslpqdwlwc etwcddeskq raktidlcnn pktkesklka aarivpewve ydaeirqlld
     1141 hlenkkqdts strsmaasas geasrsfysw wkakqeqvsy iggtgprerr grchtllnnq
     1201 ish
//
LOCUS       XP_011519402            1072 aa            linear   PRI 05-AUG-2025
DEFINITION  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X11 [Homo
            sapiens].
ACCESSION   XP_011519402
VERSION     XP_011519402.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521100.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1072
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1072
                     /product="UDP-glucose:glycoprotein glucosyltransferase 2
                     isoform X11"
                     /calculated_mol_wt=122413
     Region          45..226
                     /region_name="Thioredoxin_12"
                     /note="Thioredoxin-like domain; pfam18400"
                     /db_xref="CDD:465748"
     Region          296..424
                     /region_name="Thioredoxin_13"
                     /note="Thioredoxin-like domain; pfam18401"
                     /db_xref="CDD:465749"
     Region          437..686
                     /region_name="Thioredoxin_14"
                     /note="Thioredoxin-like domain; pfam18402"
                     /db_xref="CDD:465750"
     Region          710..933
                     /region_name="Thioredoxin_15"
                     /note="Thioredoxin-like domain; pfam18403"
                     /db_xref="CDD:465751"
     CDS             1..1072
                     /gene="UGGT2"
                     /gene_synonym="HUGT2; UGCGL2; UGT2"
                     /coded_by="XM_011521100.3:90..3308"
                     /db_xref="GeneID:55757"
                     /db_xref="HGNC:HGNC:15664"
                     /db_xref="MIM:605898"
ORIGIN      
        1 mapakatnvv rlllgstalw lsqlgsgtva asksvtahla akwpetplll easefmaees
       61 nekfwqflet vqelaiykqt esdysyynli lkkagqfldn lhinllkfaf sirayspaiq
      121 mfqqiaadep ppdgcnafvv ihkkhtckin eikkllkkaa srtrpylfkg dhkfptnken
      181 lpvvilyaem gtrtfsafhk vlsekaqnee ilyvlrhyiq kpssrkmyls gygvelaiks
      241 teykalddtq vktvtnttve detetnevqg flfgklkeiy sdlrdnltaf qkyliesnkq
      301 mmplkvwelq dlsfqaasqi msapvydsik lmkdisqnfp ikarsltria vnqhmreeik
      361 enqkdlqvrf kiqpgdarlf inglrvdmdv ydafsildml klegkmmngl rnlgingedm
      421 skflklnshi weytyvldir hssimwindl enddlyitwp tscqkllkpv fpgsvpsirr
      481 nfhnlvlfid paqeytldfi kladvfyshe vplrigfvfi lntddevdga ndagvalwra
      541 fnyiaeefdi seafisivhm yqkvkkdqni ltvdnvksvl qntfphaniw dilgihskyd
      601 eerkagasfy kmtglgplpq alyngepfkh eemnikelkm avlqrmmdas vylqrevflg
      661 tlndrtnaid flmdrnnvvp rintlilrtn qqylnlists vtadvedfst fffldsqdks
      721 aviaknmyyl tqddesiisa vtlwiiadfd kpsgrkllfn alkhmktsvh srlgiiynpt
      781 skineentai srgilaaflt qknmflrsfl gqlakeeiat aiysgdkikt fliegmdkna
      841 fekkyntvgv nifrthqlfc qdvlklrpge mgivsngrfl gpldedfyae dfyllekitf
      901 snlgekikgi venmginann msdfimkvda lmssvpkras rydvtflren hsviktnpqe
      961 ndmffnviai vdpltreaqk maqllvvlgk iinmkiklfm ncrgrlseap leritvihye
     1021 pfllmgifss pscvigqktg ilempfwevt asslqtttsk elrssfrqpl gn
//
LOCUS       XP_011519404            1031 aa            linear   PRI 05-AUG-2025
DEFINITION  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X12 [Homo
            sapiens].
ACCESSION   XP_011519404
VERSION     XP_011519404.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521102.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1031
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1031
                     /product="UDP-glucose:glycoprotein glucosyltransferase 2
                     isoform X12"
                     /calculated_mol_wt=118679
     Region          <1..127
                     /region_name="Thioredoxin_14"
                     /note="Thioredoxin-like domain; pfam18402"
                     /db_xref="CDD:465750"
     Region          151..374
                     /region_name="Thioredoxin_15"
                     /note="Thioredoxin-like domain; pfam18403"
                     /db_xref="CDD:465751"
     Region          562..667
                     /region_name="UDP-g_GGTase"
                     /note="UDP-glucose:Glycoprotein Glucosyltransferase;
                     pfam06427"
                     /db_xref="CDD:461910"
     Region          700..966
                     /region_name="Glyco_transf_24"
                     /note="Glucosyltransferase 24; pfam18404"
                     /db_xref="CDD:436473"
     CDS             1..1031
                     /gene="UGGT2"
                     /gene_synonym="HUGT2; UGCGL2; UGT2"
                     /coded_by="XM_011521102.3:94..3189"
                     /db_xref="GeneID:55757"
                     /db_xref="HGNC:HGNC:15664"
                     /db_xref="MIM:605898"
ORIGIN      
        1 myqkvkkdqn iltvdnvksv lqntfphani wdilgihsky deerkagasf ykmtglgplp
       61 qalyngepfk heemnikelk mavlqrmmda svylqrevfl gtlndrtnai dflmdrnnvv
      121 printlilrt nqqylnlist svtadvedfs tfffldsqdk saviaknmyy ltqddesiis
      181 avtlwiiadf dkpsgrkllf nalkhmktsv hsrlgiiynp tskineenta isrgilaafl
      241 tqknmflrsf lgqlakeeia taiysgdkik tfliegmdkn afekkyntvg vnifrthqlf
      301 cqdvlklrpg emgivsngrf lgpldedfya edfyllekit fsnlgekikg ivenmginan
      361 nmsdfimkvd almssvpkra srydvtflre nhsviktnpq endmffnvia ivdpltreaq
      421 kmaqllvvlg kiinmkiklf mncrgrlsea pleritvihy epfllmgifs spscvigqkt
      481 gfyrfvlepe lmsgandvss lgpvakfldi pespllilnm itpegwlvet vhsncdldni
      541 hlkdtektvt aeyeleylll egqcfdkvte qpprglqftl gtknkpavvd tivmahhgyf
      601 qlkanpgawi lrlhqgksed iyqivghegt dsqadledii vvlnsfkski lkvkvkketd
      661 kikediltde dektkglwds iksftvslhk enkkekdvln ifsvasghly erflrimmls
      721 vlrntktpvk fwllknylsp tfkeviphma keygfryelv qyrwprwlrq qterqriiwg
      781 ykilfldvlf plavdkiifv dadqivrhdl kelrdfdldg apygytpfcd srremdgyrf
      841 wktgywashl lrrkyhisal yvvdlkkfrr igagdrlrsq yqalsqdpns lsnldqdlpn
      901 nmiyqvaiks lpqdwlwcet wcddeskqra ktidlcnnpk tkesklkaaa rivpewveyd
      961 aeirqlldhl enkkqdtsst rsmaasasge asrsfyswwk akqeqvsyig gtgprerrgr
     1021 chtllnnqis h
//
LOCUS       XP_047286431            1004 aa            linear   PRI 05-AUG-2025
DEFINITION  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X13 [Homo
            sapiens].
ACCESSION   XP_047286431
VERSION     XP_047286431.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430475.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1004
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1004
                     /product="UDP-glucose:glycoprotein glucosyltransferase 2
                     isoform X13"
                     /calculated_mol_wt=115690
     Region          <1..127
                     /region_name="Thioredoxin_14"
                     /note="Thioredoxin-like domain; pfam18402"
                     /db_xref="CDD:465750"
     Region          151..374
                     /region_name="Thioredoxin_15"
                     /note="Thioredoxin-like domain; pfam18403"
                     /db_xref="CDD:465751"
     Region          535..640
                     /region_name="UDP-g_GGTase"
                     /note="UDP-glucose:Glycoprotein Glucosyltransferase;
                     pfam06427"
                     /db_xref="CDD:461910"
     Region          673..939
                     /region_name="Glyco_transf_24"
                     /note="Glucosyltransferase 24; pfam18404"
                     /db_xref="CDD:436473"
     CDS             1..1004
                     /gene="UGGT2"
                     /gene_synonym="HUGT2; UGCGL2; UGT2"
                     /coded_by="XM_047430475.1:94..3108"
                     /db_xref="GeneID:55757"
                     /db_xref="HGNC:HGNC:15664"
                     /db_xref="MIM:605898"
ORIGIN      
        1 myqkvkkdqn iltvdnvksv lqntfphani wdilgihsky deerkagasf ykmtglgplp
       61 qalyngepfk heemnikelk mavlqrmmda svylqrevfl gtlndrtnai dflmdrnnvv
      121 printlilrt nqqylnlist svtadvedfs tfffldsqdk saviaknmyy ltqddesiis
      181 avtlwiiadf dkpsgrkllf nalkhmktsv hsrlgiiynp tskineenta isrgilaafl
      241 tqknmflrsf lgqlakeeia taiysgdkik tfliegmdkn afekkyntvg vnifrthqlf
      301 cqdvlklrpg emgivsngrf lgpldedfya edfyllekit fsnlgekikg ivenmginan
      361 nmsdfimkvd almssvpkra srydvtflre nhsviktnpq endmffnvia ivdpltreaq
      421 kmaqllvvlg kiinmkiklf mncrgrlsea plesfyrfvl epelmsgand vsslgpvakf
      481 ldipesplli lnmitpegwl vetvhsncdl dnihlkdtek tvtaeyeley lllegqcfdk
      541 vteqpprglq ftlgtknkpa vvdtivmahh gyfqlkanpg awilrlhqgk sediyqivgh
      601 egtdsqadle diivvlnsfk skilkvkvkk etdkikedil tdedektkgl wdsiksftvs
      661 lhkenkkekd vlnifsvasg hlyerflrim mlsvlrntkt pvkfwllkny lsptfkevip
      721 hmakeygfry elvqyrwprw lrqqterqri iwgykilfld vlfplavdki ifvdadqivr
      781 hdlkelrdfd ldgapygytp fcdsrremdg yrfwktgywa shllrrkyhi salyvvdlkk
      841 frrigagdrl rsqyqalsqd pnslsnldqd lpnnmiyqva ikslpqdwlw cetwcddesk
      901 qraktidlcn npktkesklk aaarivpewv eydaeirqll dhlenkkqdt sstrsmaasa
      961 sgeasrsfys wwkakqeqvs yiggtgprer rgrchtllnn qish
//
LOCUS       XP_011519405             918 aa            linear   PRI 05-AUG-2025
DEFINITION  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X14 [Homo
            sapiens].
ACCESSION   XP_011519405
VERSION     XP_011519405.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521103.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..918
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..918
                     /product="UDP-glucose:glycoprotein glucosyltransferase 2
                     isoform X14"
                     /calculated_mol_wt=105632
     Region          38..261
                     /region_name="Thioredoxin_15"
                     /note="Thioredoxin-like domain; pfam18403"
                     /db_xref="CDD:465751"
     Region          449..554
                     /region_name="UDP-g_GGTase"
                     /note="UDP-glucose:Glycoprotein Glucosyltransferase;
                     pfam06427"
                     /db_xref="CDD:461910"
     Region          587..853
                     /region_name="Glyco_transf_24"
                     /note="Glucosyltransferase 24; pfam18404"
                     /db_xref="CDD:436473"
     CDS             1..918
                     /gene="UGGT2"
                     /gene_synonym="HUGT2; UGCGL2; UGT2"
                     /coded_by="XM_011521103.3:129..2885"
                     /db_xref="GeneID:55757"
                     /db_xref="HGNC:HGNC:15664"
                     /db_xref="MIM:605898"
ORIGIN      
        1 mdrnnvvpri ntlilrtnqq ylnlistsvt advedfstff fldsqdksav iaknmyyltq
       61 ddesiisavt lwiiadfdkp sgrkllfnal khmktsvhsr lgiiynptsk ineentaisr
      121 gilaafltqk nmflrsflgq lakeeiatai ysgdkiktfl iegmdknafe kkyntvgvni
      181 frthqlfcqd vlklrpgemg ivsngrflgp ldedfyaedf yllekitfsn lgekikgive
      241 nmginannms dfimkvdalm ssvpkrasry dvtflrenhs viktnpqend mffnviaivd
      301 pltreaqkma qllvvlgkii nmkiklfmnc rgrlseaple ritvihyepf llmgifssps
      361 cvigqktgfy rfvlepelms gandvsslgp vakfldipes pllilnmitp egwlvetvhs
      421 ncdldnihlk dtektvtaey eleylllegq cfdkvteqpp rglqftlgtk nkpavvdtiv
      481 mahhgyfqlk anpgawilrl hqgksediyq ivghegtdsq adlediivvl nsfkskilkv
      541 kvkketdkik ediltdedek tkglwdsiks ftvslhkenk kekdvlnifs vasghlyerf
      601 lrimmlsvlr ntktpvkfwl lknylsptfk eviphmakey gfryelvqyr wprwlrqqte
      661 rqriiwgyki lfldvlfpla vdkiifvdad qivrhdlkel rdfdldgapy gytpfcdsrr
      721 emdgyrfwkt gywashllrr kyhisalyvv dlkkfrriga gdrlrsqyqa lsqdpnslsn
      781 ldqdlpnnmi yqvaikslpq dwlwcetwcd deskqrakti dlcnnpktke sklkaaariv
      841 pewveydaei rqlldhlenk kqdtsstrsm aasasgeasr sfyswwkakq eqvsyiggtg
      901 prerrgrcht llnnqish
//
LOCUS       XP_047286433             421 aa            linear   PRI 05-AUG-2025
DEFINITION  PCI domain-containing protein 2 isoform X1 [Homo sapiens].
ACCESSION   XP_047286433
VERSION     XP_047286433.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430477.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..421
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..421
                     /product="PCI domain-containing protein 2 isoform X1"
                     /calculated_mol_wt=48001
     Region          80..368
                     /region_name="PINT"
                     /note="motif in proteasome subunits, Int-6, Nip-1 and
                     TRIP-15; cl02111"
                     /db_xref="CDD:470471"
     CDS             1..421
                     /gene="PCID2"
                     /gene_synonym="F10"
                     /coded_by="XM_047430477.1:36..1301"
                     /db_xref="GeneID:55795"
                     /db_xref="HGNC:HGNC:25653"
                     /db_xref="MIM:613713"
ORIGIN      
        1 mahitinqyl qqvyeaidsr dgascaelvs fkhphvanpr lqmaspeekc qqvleppyde
       61 mfaahlrcty avgnhdfiea ykcqtvivqs flrafqahke enwalpvmya valdlrvfan
      121 nadqqlvkkg kskvgdmlek aaellmscfr vcasdtragi edskkwgmlf lvnqlfkiyf
      181 kinklhlckp liraidssnl kddystaqrv tykyyvgrka mfdsdfkqae eylsfafehc
      241 hrssqknkrm iliyllpvkm llghmptvel lkkyhlmqfa evtravsegn llllhealak
      301 heaffircgi flileklkii tyrnlfkkvy lllkthqlsl daflvalkfm qvedvdidev
      361 qcilanliym vwtrqrlhia saseaggqqa episspvhgv lkvhgaprtd sagsgvfvrl
      421 l
//
LOCUS       XP_047286434             408 aa            linear   PRI 05-AUG-2025
DEFINITION  PCI domain-containing protein 2 isoform X2 [Homo sapiens].
ACCESSION   XP_047286434
VERSION     XP_047286434.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430478.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..408
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..408
                     /product="PCI domain-containing protein 2 isoform X2"
                     /calculated_mol_wt=46613
     Region          78..366
                     /region_name="PINT"
                     /note="motif in proteasome subunits, Int-6, Nip-1 and
                     TRIP-15; cl02111"
                     /db_xref="CDD:470471"
     CDS             1..408
                     /gene="PCID2"
                     /gene_synonym="F10"
                     /coded_by="XM_047430478.1:617..1843"
                     /db_xref="GeneID:55795"
                     /db_xref="HGNC:HGNC:25653"
                     /db_xref="MIM:613713"
ORIGIN      
        1 mrltdvvqql vyeaidsrdg ascaelvsfk hphvanprlq maspeekcqq vleppydemf
       61 aahlrctyav gnhdfieayk cqtvivqsfl rafqahkeen walpvmyava ldlrvfanna
      121 dqqlvkkgks kvgdmlekaa ellmscfrvc asdtragied skkwgmlflv nqlfkiyfki
      181 nklhlckpli raidssnlkd dystaqrvty kyyvgrkamf dsdfkqaeey lsfafehchr
      241 ssqknkrmil iyllpvkmll ghmptvellk kyhlmqfaev travsegnll llhealakhe
      301 affircgifl ileklkiity rnlfkkvyll lkthqlslda flvalkfmqv edvdidevqc
      361 ilanliymvw trqrlhiasa seaggqqaep isspvhgvlk vhgaprta
//
LOCUS       XP_047286435             390 aa            linear   PRI 05-AUG-2025
DEFINITION  PCI domain-containing protein 2 isoform X3 [Homo sapiens].
ACCESSION   XP_047286435
VERSION     XP_047286435.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430479.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..390
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..390
                     /product="PCI domain-containing protein 2 isoform X3"
                     /calculated_mol_wt=44682
     Region          38..326
                     /region_name="PINT"
                     /note="motif in proteasome subunits, Int-6, Nip-1 and
                     TRIP-15; cl02111"
                     /db_xref="CDD:470471"
     CDS             1..390
                     /gene="PCID2"
                     /gene_synonym="F10"
                     /coded_by="XM_047430479.1:137..1309"
                     /db_xref="GeneID:55795"
                     /db_xref="HGNC:HGNC:25653"
                     /db_xref="MIM:613713"
ORIGIN      
        1 maspeekcqq vleppydemf aahlrctyav gnhdfieayk cqtvivqsfl rafqahkeen
       61 walpvmyava ldlrvfanna dqqlvkkgks kvgdmlekaa ellmscfrvc asdtragied
      121 skkwgmlflv nqlfkiyfki nklhlckpli raidssnlkd dystaqrvty kyyvgrkamf
      181 dsdfkqaeey lsfafehchr ssqknkrmil iyllpvkmll ghmptvellk kyhlmqfaev
      241 travsegnll llhealakhe affircgifl ileklkiity rnlfkkvyll lkthqlslda
      301 flvalkfmqv edvdidevqc ilanliymvw trqrlhiasa seaggqqaep isspvhgvlk
      361 vhgaprtgeq lflstlvvlm rpvrycnkap
//
LOCUS       XP_047286436             265 aa            linear   PRI 05-AUG-2025
DEFINITION  PCI domain-containing protein 2 isoform X4 [Homo sapiens].
ACCESSION   XP_047286436
VERSION     XP_047286436.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430480.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..265
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..265
                     /product="PCI domain-containing protein 2 isoform X4"
                     /calculated_mol_wt=30578
     Region          <2..201
                     /region_name="PINT"
                     /note="motif in proteasome subunits, Int-6, Nip-1 and
                     TRIP-15; cl02111"
                     /db_xref="CDD:470471"
     CDS             1..265
                     /gene="PCID2"
                     /gene_synonym="F10"
                     /coded_by="XM_047430480.1:78..875"
                     /db_xref="GeneID:55795"
                     /db_xref="HGNC:HGNC:25653"
                     /db_xref="MIM:613713"
ORIGIN      
        1 mlflvnqlfk iyfkinklhl ckpliraids snlkddysta qrvtykyyvg rkamfdsdfk
       61 qaeeylsfaf ehchrssqkn krmiliyllp vkmllghmpt vellkkyhlm qfaevtravs
      121 egnllllhea lakheaffir cgiflilekl kiityrnlfk kvylllkthq lsldaflval
      181 kfmqvedvdi devqcilanl iymvwtrqrl hiasaseagg qqaepisspv hgvlkvhgap
      241 rtgeqlflst lvvlmrpvry cnkap
//
LOCUS       XP_005268382             239 aa            linear   PRI 05-AUG-2025
DEFINITION  PCI domain-containing protein 2 isoform X5 [Homo sapiens].
ACCESSION   XP_005268382
VERSION     XP_005268382.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005268325.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..239
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..239
                     /product="PCI domain-containing protein 2 isoform X5"
                     /calculated_mol_wt=27112
     Region          80..>228
                     /region_name="PINT"
                     /note="motif in proteasome subunits, Int-6, Nip-1 and
                     TRIP-15; cl02111"
                     /db_xref="CDD:470471"
     CDS             1..239
                     /gene="PCID2"
                     /gene_synonym="F10"
                     /coded_by="XM_005268325.5:36..755"
                     /db_xref="GeneID:55795"
                     /db_xref="HGNC:HGNC:25653"
                     /db_xref="MIM:613713"
ORIGIN      
        1 mahitinqyl qqvyeaidsr dgascaelvs fkhphvanpr lqmaspeekc qqvleppyde
       61 mfaahlrcty avgnhdfiea ykcqtvivqs flrafqahke enwalpvmya valdlrvfan
      121 nadqqlvkkg kskvgdmlek aaellmscfr vcasdtragi edskkwgmlf lvnqlfkiyf
      181 kinklhlckp liraidssnl kddystaqrv tykyyvgrka mfdsdfkqda gyvdigngd
//
LOCUS       XP_047286437             237 aa            linear   PRI 05-AUG-2025
DEFINITION  PCI domain-containing protein 2 isoform X6 [Homo sapiens].
ACCESSION   XP_047286437
VERSION     XP_047286437.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430481.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..237
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..237
                     /product="PCI domain-containing protein 2 isoform X6"
                     /calculated_mol_wt=26855
     Region          78..>226
                     /region_name="PINT"
                     /note="motif in proteasome subunits, Int-6, Nip-1 and
                     TRIP-15; cl02111"
                     /db_xref="CDD:470471"
     CDS             1..237
                     /gene="PCID2"
                     /gene_synonym="F10"
                     /coded_by="XM_047430481.1:617..1330"
                     /db_xref="GeneID:55795"
                     /db_xref="HGNC:HGNC:25653"
                     /db_xref="MIM:613713"
ORIGIN      
        1 mrltdvvqql vyeaidsrdg ascaelvsfk hphvanprlq maspeekcqq vleppydemf
       61 aahlrctyav gnhdfieayk cqtvivqsfl rafqahkeen walpvmyava ldlrvfanna
      121 dqqlvkkgks kvgdmlekaa ellmscfrvc asdtragied skkwgmlflv nqlfkiyfki
      181 nklhlckpli raidssnlkd dystaqrvty kyyvgrkamf dsdfkqdagy vdigngd
//
LOCUS       XP_047286439            1338 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal P4.1-associated protein isoform X1 [Homo sapiens].
ACCESSION   XP_047286439
VERSION     XP_047286439.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430483.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1338
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1338
                     /product="centrosomal P4.1-associated protein isoform X1"
                     /calculated_mol_wt=152870
     Region          <886..1148
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          1152..1180
                     /region_name="Tcp10_C"
                     /note="T-complex protein 10 C-terminus; pfam07202"
                     /db_xref="CDD:462118"
     Region          1225..1253
                     /region_name="Tcp10_C"
                     /note="T-complex protein 10 C-terminus; pfam07202"
                     /db_xref="CDD:462118"
     Region          1261..1289
                     /region_name="Tcp10_C"
                     /note="T-complex protein 10 C-terminus; pfam07202"
                     /db_xref="CDD:462118"
     Region          1296..1325
                     /region_name="Tcp10_C"
                     /note="T-complex protein 10 C-terminus; pfam07202"
                     /db_xref="CDD:462118"
     CDS             1..1338
                     /gene="CPAP"
                     /gene_synonym="BM032; CENP-J; CENPJ; LAP; LIP1; MCPH6;
                     Sas-4; SASS4; SCKL4"
                     /coded_by="XM_047430483.1:672..4688"
                     /db_xref="GeneID:55835"
                     /db_xref="HGNC:HGNC:17272"
                     /db_xref="MIM:609279"
ORIGIN      
        1 mflmptssel nsgqnfltqw mtnpsragvi lnrgfpilea dkekraavdi stsfpikgth
       61 fsdsfsfine edslleeqkl esnnpykpqs dksethtafp cikkgpqvaa chsapghqee
      121 nkndfipdla sefkegaykd plfkkleqlk evqqkkqeql krqqleqlqr lmeeqekllt
      181 mvsgqctlpg lsllpddqsq khrspgnttt geratccfps yvypdptqee typsnilshe
      241 qsnfcrtahg dfvltskras pnlfseaqyq eapveknnlk eenrnhptge silcwekvte
      301 qiqeandknl qkhddsseva nieerpikaa igerkqtfed yleeqiqlee qelkqkqlke
      361 aegplpikak pkqpflkrge glarftnaks kfqkgkeskl vtnqstsedq plfkmdrqql
      421 qrktalknke lcadnpilkk dskartksgs vtlsqkpkml kcsnrkslsp sglkiqtgkk
      481 cdgqfrdqik fenkvtsnnk envtecpkpc dtgctgwnkt qgkdrlplst gpasrlaaks
      541 piretmkese ssldvslqkk letwerekek enleldeflf leqaadeisf ssnssfvlki
      601 lerdqqickg hrmsstpvka vpqktnpadp ishcnrsedl dhtarekese cevapkqlhs
      661 lssadelreq pckirkavqk stsenqtewn arddegvpns dsstdseeql dvtikpsted
      721 rergissred spqvcddkgp fkdtrtqedk rrdvdldlsd kdyssdesim esikhkvsep
      781 srssslslsk mdfddertwt dleenlcnhd vvlgnestyg tpqtcypnne igildktikr
      841 kiapvkrged lsksrrsrsp ptselmmkff pslkpkpksd shlgnelkln isqdqppgdn
      901 arsqvlreki ieleteiekf kaenaslakl rieresalek lrkeiadfeq qkakelarie
      961 efkkeemrkl qkerkvfeky ttaartfpdk kereeiqtlk qqiadlredl krketkwsst
     1021 hsrlrsqiqm lvrentdlre eikvmerfrl dawkraeaie sslevekkdk lantsvrfqn
     1081 sqissgtqve kykknylpmq gnpprrsksa pprdlgnldk gqaasprepl eplnfpdpey
     1141 keeeedqdiq geishpdgkv ekvykngcrv ilfpngtrke vsadgktitv tffngdvkqv
     1201 mpdqrviyyy aaaqtthtty peglevlhfs sgqiekhypd grkeitfpdq tvknlfpdgq
     1261 eesifpdgti vrvqrdgnkl iefnngqrel htaqfkrrey pdgtvktvya nghqetkyrs
     1321 grirvkdkeg nvlmdtel
//
LOCUS       XP_047286440            1136 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal P4.1-associated protein isoform X2 [Homo sapiens].
ACCESSION   XP_047286440
VERSION     XP_047286440.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430484.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1136
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1136
                     /product="centrosomal P4.1-associated protein isoform X2"
                     /calculated_mol_wt=129800
     Region          <898..>1079
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1136
                     /gene="CPAP"
                     /gene_synonym="BM032; CENP-J; CENPJ; LAP; LIP1; MCPH6;
                     Sas-4; SASS4; SCKL4"
                     /coded_by="XM_047430484.1:168..3578"
                     /db_xref="GeneID:55835"
                     /db_xref="HGNC:HGNC:17272"
                     /db_xref="MIM:609279"
ORIGIN      
        1 mflmptssel nsgqnfltqw mtnpsragvi lnrgfpilea dkekraavdi stsfpikgth
       61 fsdsfsfine edslleeqkl esnnpykpqs dksethtafp cikkgpqvaa chsapghqee
      121 nkndfipdla sefkegaykd plfkkleqlk evqqkkqeql krqqleqlqr lmeeqekllt
      181 mvsgqctlpg lsllpddqsq khrspgnttt geratccfps yvypdptqee typsnilshe
      241 qsnfcrtahg dfvltskras pnlfseaqyq eapveknnlk eenrnhptge silcwekvte
      301 qiqeandknl qkhddsseva nieerpikaa igerkqtfed yleeqiqlee qelkqkqlke
      361 aegplpikak pkqpflkrge glarftnaks kfqkgkeskl vtnqstsedq plfkmdrqql
      421 qrktalknke lcadnpilkk dskartksgs vtlsqkpkml kcsnrkslsp sglkiqtgkk
      481 cdgqfrdqik fenkvtsnnk envtecpkpc dtgctgwnkt qgkdrlplst gpasrlaaks
      541 piretmkese ssldvslqkk letwerekek enleldeflf leqaadeisf ssnssfvlki
      601 lerdqqickg hrmsstpvka vpqktnpadp ishcnrsedl dhtarekese cevapkqlhs
      661 lssadelreq pckirkavqk stsenqtewn arddegvpns dsstdseeql dvtikpsted
      721 rergissred spqvcddkgp fkdtrtqedk rrdvdldlsd kdyssdesim esikhkvsep
      781 srssslslsk mdfddertwt dleenlcnhd vvlgnestyg tpqtcypnne igildktikr
      841 kiapvkrged lsksrrsrsp ptselmmkff pslkpkpksd shlgnelkln isqdqppgdn
      901 arsqvlreki ieleteiekf kaenaslakl rieresalek lrkeiadfeq qkakelarie
      961 efkkeemrkl qkerkvfeky ttaartfpdk kereeiqtlk qqiadlredl krketkwsst
     1021 hsrlrsqiqm lvrentdlre eikvmerfrl dawkraeaie sslevekkdk lantsvrfqn
     1081 sqissgtqve kykknylpmq gtaqpphtps slladhlppl ssfrpfsrni qlcytf
//
LOCUS       XP_011533451            1136 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal P4.1-associated protein isoform X2 [Homo sapiens].
ACCESSION   XP_011533451
VERSION     XP_011533451.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535149.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1136
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1136
                     /product="centrosomal P4.1-associated protein isoform X2"
                     /calculated_mol_wt=129800
     Region          <898..>1079
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1136
                     /gene="CPAP"
                     /gene_synonym="BM032; CENP-J; CENPJ; LAP; LIP1; MCPH6;
                     Sas-4; SASS4; SCKL4"
                     /coded_by="XM_011535149.3:168..3578"
                     /db_xref="GeneID:55835"
                     /db_xref="HGNC:HGNC:17272"
                     /db_xref="MIM:609279"
ORIGIN      
        1 mflmptssel nsgqnfltqw mtnpsragvi lnrgfpilea dkekraavdi stsfpikgth
       61 fsdsfsfine edslleeqkl esnnpykpqs dksethtafp cikkgpqvaa chsapghqee
      121 nkndfipdla sefkegaykd plfkkleqlk evqqkkqeql krqqleqlqr lmeeqekllt
      181 mvsgqctlpg lsllpddqsq khrspgnttt geratccfps yvypdptqee typsnilshe
      241 qsnfcrtahg dfvltskras pnlfseaqyq eapveknnlk eenrnhptge silcwekvte
      301 qiqeandknl qkhddsseva nieerpikaa igerkqtfed yleeqiqlee qelkqkqlke
      361 aegplpikak pkqpflkrge glarftnaks kfqkgkeskl vtnqstsedq plfkmdrqql
      421 qrktalknke lcadnpilkk dskartksgs vtlsqkpkml kcsnrkslsp sglkiqtgkk
      481 cdgqfrdqik fenkvtsnnk envtecpkpc dtgctgwnkt qgkdrlplst gpasrlaaks
      541 piretmkese ssldvslqkk letwerekek enleldeflf leqaadeisf ssnssfvlki
      601 lerdqqickg hrmsstpvka vpqktnpadp ishcnrsedl dhtarekese cevapkqlhs
      661 lssadelreq pckirkavqk stsenqtewn arddegvpns dsstdseeql dvtikpsted
      721 rergissred spqvcddkgp fkdtrtqedk rrdvdldlsd kdyssdesim esikhkvsep
      781 srssslslsk mdfddertwt dleenlcnhd vvlgnestyg tpqtcypnne igildktikr
      841 kiapvkrged lsksrrsrsp ptselmmkff pslkpkpksd shlgnelkln isqdqppgdn
      901 arsqvlreki ieleteiekf kaenaslakl rieresalek lrkeiadfeq qkakelarie
      961 efkkeemrkl qkerkvfeky ttaartfpdk kereeiqtlk qqiadlredl krketkwsst
     1021 hsrlrsqiqm lvrentdlre eikvmerfrl dawkraeaie sslevekkdk lantsvrfqn
     1081 sqissgtqve kykknylpmq gtaqpphtps slladhlppl ssfrpfsrni qlcytf
//
LOCUS       XP_011533452            1129 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal P4.1-associated protein isoform X3 [Homo sapiens].
ACCESSION   XP_011533452
VERSION     XP_011533452.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535150.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1129
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1129
                     /product="centrosomal P4.1-associated protein isoform X3"
                     /calculated_mol_wt=129143
     Region          <900..>1105
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     CDS             1..1129
                     /gene="CPAP"
                     /gene_synonym="BM032; CENP-J; CENPJ; LAP; LIP1; MCPH6;
                     Sas-4; SASS4; SCKL4"
                     /coded_by="XM_011535150.3:168..3557"
                     /db_xref="GeneID:55835"
                     /db_xref="HGNC:HGNC:17272"
                     /db_xref="MIM:609279"
ORIGIN      
        1 mflmptssel nsgqnfltqw mtnpsragvi lnrgfpilea dkekraavdi stsfpikgth
       61 fsdsfsfine edslleeqkl esnnpykpqs dksethtafp cikkgpqvaa chsapghqee
      121 nkndfipdla sefkegaykd plfkkleqlk evqqkkqeql krqqleqlqr lmeeqekllt
      181 mvsgqctlpg lsllpddqsq khrspgnttt geratccfps yvypdptqee typsnilshe
      241 qsnfcrtahg dfvltskras pnlfseaqyq eapveknnlk eenrnhptge silcwekvte
      301 qiqeandknl qkhddsseva nieerpikaa igerkqtfed yleeqiqlee qelkqkqlke
      361 aegplpikak pkqpflkrge glarftnaks kfqkgkeskl vtnqstsedq plfkmdrqql
      421 qrktalknke lcadnpilkk dskartksgs vtlsqkpkml kcsnrkslsp sglkiqtgkk
      481 cdgqfrdqik fenkvtsnnk envtecpkpc dtgctgwnkt qgkdrlplst gpasrlaaks
      541 piretmkese ssldvslqkk letwerekek enleldeflf leqaadeisf ssnssfvlki
      601 lerdqqickg hrmsstpvka vpqktnpadp ishcnrsedl dhtarekese cevapkqlhs
      661 lssadelreq pckirkavqk stsenqtewn arddegvpns dsstdseeql dvtikpsted
      721 rergissred spqvcddkgp fkdtrtqedk rrdvdldlsd kdyssdesim esikhkvsep
      781 srssslslsk mdfddertwt dleenlcnhd vvlgnestyg tpqtcypnne igildktikr
      841 kiapvkrged lsksrrsrsp ptselmmkff pslkpkpksd shlgnelkln isqdqppgdn
      901 arsqvlreki ieleteiekf kaenaslakl rieresalek lrkeiadfeq qkakelarie
      961 efkkeemrkl qkerkvfeky ttaartfpdk kereeiqtlk qqiadlredl krketkwsst
     1021 hsrlrsqiqm lvrentdlre eikvmerfrl dawkraeaie sslevekkdk lavpltrsnr
     1081 kkgahghqel rlgqgklkcl rdtqeirlgs ctrqhrlqlg thtwdrlnv
//
LOCUS       XP_016876162            1015 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal P4.1-associated protein isoform X4 [Homo sapiens].
ACCESSION   XP_016876162
VERSION     XP_016876162.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020673.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1015
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1015
                     /product="centrosomal P4.1-associated protein isoform X4"
                     /calculated_mol_wt=115667
     Region          <888..>979
                     /region_name="ClpA"
                     /note="ATP-dependent Clp protease, ATP-binding subunit
                     ClpA [Posttranslational modification, protein turnover,
                     chaperones]; COG0542"
                     /db_xref="CDD:440308"
     CDS             1..1015
                     /gene="CPAP"
                     /gene_synonym="BM032; CENP-J; CENPJ; LAP; LIP1; MCPH6;
                     Sas-4; SASS4; SCKL4"
                     /coded_by="XM_017020673.2:168..3215"
                     /db_xref="GeneID:55835"
                     /db_xref="HGNC:HGNC:17272"
                     /db_xref="MIM:609279"
ORIGIN      
        1 mflmptssel nsgqnfltqw mtnpsragvi lnrgfpilea dkekraavdi stsfpikgth
       61 fsdsfsfine edslleeqkl esnnpykpqs dksethtafp cikkgpqvaa chsapghqee
      121 nkndfipdla sefkegaykd plfkkleqlk evqqkkqeql krqqleqlqr lmeeqekllt
      181 mvsgqctlpg lsllpddqsq khrspgnttt geratccfps yvypdptqee typsnilshe
      241 qsnfcrtahg dfvltskras pnlfseaqyq eapveknnlk eenrnhptge silcwekvte
      301 qiqeandknl qkhddsseva nieerpikaa igerkqtfed yleeqiqlee qelkqkqlke
      361 aegplpikak pkqpflkrge glarftnaks kfqkgkeskl vtnqstsedq plfkmdrqql
      421 qrktalknke lcadnpilkk dskartksgs vtlsqkpkml kcsnrkslsp sglkiqtgkk
      481 cdgqfrdqik fenkvtsnnk envtecpkpc dtgctgwnkt qgkdrlplst gpasrlaaks
      541 piretmkese ssldvslqkk letwerekek enleldeflf leqaadeisf ssnssfvlki
      601 lerdqqickg hrmsstpvka vpqktnpadp ishcnrsedl dhtarekese cevapkqlhs
      661 lssadelreq pckirkavqk stsenqtewn arddegvpns dsstdseeql dvtikpsted
      721 rergissred spqvcddkgp fkdtrtqedk rrdvdldlsd kdyssdesim esikhkvsep
      781 srssslslsk mdfddertwt dleenlcnhd vvlgnestyg tpqtcypnne igildktikr
      841 kiapvkrged lsksrrsrsp ptselmmkff pslkpkpksd shlgnelkln isqdqppgdn
      901 arsqvlreki ieleteiekf kaenaslakl rieresalek lrkeiadfeq qkakelarie
      961 efkkeemrkl qkerkvfeky ttaartfpdk kereeiqhma teyllcsrhi lamqq
//
LOCUS       XP_047286441             999 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal P4.1-associated protein isoform X5 [Homo sapiens].
ACCESSION   XP_047286441
VERSION     XP_047286441.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430485.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..999
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..999
                     /product="centrosomal P4.1-associated protein isoform X5"
                     /calculated_mol_wt=113809
     Region          <901..>999
                     /region_name="COG2433"
                     /note="Possible nuclease of RNase H fold, RuvC/YqgF family
                     [General function prediction only]"
                     /db_xref="CDD:441980"
     CDS             1..999
                     /gene="CPAP"
                     /gene_synonym="BM032; CENP-J; CENPJ; LAP; LIP1; MCPH6;
                     Sas-4; SASS4; SCKL4"
                     /coded_by="XM_047430485.1:168..3167"
                     /db_xref="GeneID:55835"
                     /db_xref="HGNC:HGNC:17272"
                     /db_xref="MIM:609279"
ORIGIN      
        1 mflmptssel nsgqnfltqw mtnpsragvi lnrgfpilea dkekraavdi stsfpikgth
       61 fsdsfsfine edslleeqkl esnnpykpqs dksethtafp cikkgpqvaa chsapghqee
      121 nkndfipdla sefkegaykd plfkkleqlk evqqkkqeql krqqleqlqr lmeeqekllt
      181 mvsgqctlpg lsllpddqsq khrspgnttt geratccfps yvypdptqee typsnilshe
      241 qsnfcrtahg dfvltskras pnlfseaqyq eapveknnlk eenrnhptge silcwekvte
      301 qiqeandknl qkhddsseva nieerpikaa igerkqtfed yleeqiqlee qelkqkqlke
      361 aegplpikak pkqpflkrge glarftnaks kfqkgkeskl vtnqstsedq plfkmdrqql
      421 qrktalknke lcadnpilkk dskartksgs vtlsqkpkml kcsnrkslsp sglkiqtgkk
      481 cdgqfrdqik fenkvtsnnk envtecpkpc dtgctgwnkt qgkdrlplst gpasrlaaks
      541 piretmkese ssldvslqkk letwerekek enleldeflf leqaadeisf ssnssfvlki
      601 lerdqqickg hrmsstpvka vpqktnpadp ishcnrsedl dhtarekese cevapkqlhs
      661 lssadelreq pckirkavqk stsenqtewn arddegvpns dsstdseeql dvtikpsted
      721 rergissred spqvcddkgp fkdtrtqedk rrdvdldlsd kdyssdesim esikhkvsep
      781 srssslslsk mdfddertwt dleenlcnhd vvlgnestyg tpqtcypnne igildktikr
      841 kiapvkrged lsksrrsrsp ptselmmkff pslkpkpksd shlgnelkln isqdqppgdn
      901 arsqvlreki ieleteiekf kaenaslakl rieresalek lrkeiadfeq qkakelarie
      961 efkkeemrkl qkerkvfeky ttaartfpdk kereeiqrl
//
LOCUS       XP_011533454            1699 aa            linear   PRI 05-AUG-2025
DEFINITION  RING finger protein 17 isoform X1 [Homo sapiens].
ACCESSION   XP_011533454
VERSION     XP_011533454.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535152.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1699
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1699
                     /product="RING finger protein 17 isoform X1"
                     /calculated_mol_wt=193173
     Region          <74..101
                     /region_name="RING_Ubox"
                     /note="RING finger (Really Interesting New Gene) domain
                     and U-box domain superfamily; cl17238"
                     /db_xref="CDD:473075"
     Region          492..568
                     /region_name="Tudor_TDRD4_rpt1"
                     /note="first Tudor domain found in Tudor domain-containing
                     protein 4 (TDRD4) and similar proteins; cd20414"
                     /db_xref="CDD:410485"
     Site            order(501,508,544,547,549)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410485"
     Region          730..874
                     /region_name="Tudor_TDRD4_rpt2"
                     /note="second Tudor domain found in Tudor
                     domain-containing protein 4 (TDRD4) and similar proteins;
                     cd20415"
                     /db_xref="CDD:410486"
     Site            order(764,770,836,839,841)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410486"
     Region          1021..1102
                     /region_name="Tudor_TDRD4_rpt3"
                     /note="third Tudor domain found in Tudor domain-containing
                     protein 4 (TDRD4) and similar proteins; cd20416"
                     /db_xref="CDD:410487"
     Site            order(1049,1056,1073,1076,1078)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410487"
     Region          1305..1372
                     /region_name="Tudor_TDRD4_rpt4"
                     /note="fourth Tudor domain found in Tudor
                     domain-containing protein 4 (TDRD4) and similar proteins;
                     cd20417"
                     /db_xref="CDD:410488"
     Site            order(1315,1321,1337,1340,1342)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410488"
     Region          1553..1657
                     /region_name="Tudor_TDRD4_rpt5"
                     /note="fifth Tudor domain found in Tudor domain-containing
                     protein 4 (TDRD4) and similar proteins; cd20418"
                     /db_xref="CDD:410489"
     Site            order(1566,1572,1591,1594,1596)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410489"
     CDS             1..1699
                     /gene="RNF17"
                     /gene_synonym="Mmip-2; SPATA23; TDRD4"
                     /coded_by="XM_011535152.3:1754..6853"
                     /db_xref="GeneID:56163"
                     /db_xref="HGNC:HGNC:10060"
                     /db_xref="MIM:605793"
ORIGIN      
        1 mkasfhnekg lasndwslpr gppglalggc srrkrqrwrq rlrrlgllgl ptsewggrvs
       61 pgvplkssap ghhcelqcgh afcelcllmt eecttiicpd cevatavntr qryypmagyi
      121 kedsimeklq pktikncsqd fkktadqltt glersastdk tllnssavml dtntaeeide
      181 alntahhsfe qlsiagkale hmqkqtieer ervievvekq fdqllaffds rkknlceefa
      241 rttddylsnl ikaksyieek knnlnaamni aralqlspsl rtycdlnqii rtlqltsdse
      301 laqvsspqlr npprlsvncs eiicmfnnmg kiefrdstkc ypqeneirqn vqkkynnkke
      361 lscydtyppl ekkkvdmsvl tseapppplq petndvhlea knfqpqkdva taspktiavl
      421 pqmgsspdvi ieeiiednve ssaelvfvsh vidpchfyir kysqikdakv lekkvnefcn
      481 rsshldpsdi lelgarifvs sikngmwcrg titelipieg rntrkpcspt rlfvhevali
      541 qifmvdfgns evlivtgvvd thvrpehsak qhialndlcl vlrksepyte gllkdiqpla
      601 qpcslkdivp qnsnegweee akveflkmvn nkavsmkvfr eedgvlivdl qkpppnkiss
      661 dmpvslrdal vfmelakfks qslrshfekn ttlhyhppil pkemtdvsvt vchinspgdf
      721 ylqliegldi lfllktieef yksedgenle ilcpvqdqac vakfedgiwy rakvielnhw
      781 escwkscidr tkqqkliiqk pvnsslmltv clshailivk vqikglpghq evevkyvdfg
      841 ntakitikdv rkikdeflna pekaikckla yiepykrtmq wskeakekfe ekaqdkfmtc
      901 svikilednv llvelfdslg apemtttsin dqlvkeglas yeigyilkdn sqkhievwdp
      961 speeiisnev hnlnpvsaks lpnenfqsly nkelpvhicn vispekiyvq wlltenllns
     1021 leekmiaaye nskwepvkwe ndmhcavkiq dknqwrrgqi irmvtdtlve vllydvgvel
     1081 vvnvdclrkl eenlktmgrl slecslvdir paggsdkwta tacdclslyl tgavatiilq
     1141 vdseennttw plpvkifcrd ekgervdvsk ylikkglalr errinnldns hslsekslev
     1201 pleqedsvvt nciktnfdpd kktadiiseq kvsefqekil eprttrgykp paipnmnvfe
     1261 atvscvgddg tifvvpklse felikmtnei qsnlkclgll epyfwkkgea cavrgsdtlw
     1321 yrgkvmevvg gavrvqyldh gftekipqch lypillypdi pqfcipcqlh nttpvgnvwq
     1381 pdaievlqql lskrqvdihi melpknpwek lsihlyfdgm slsyfmayyk yctsehteem
     1441 lkekprsdhd kkyeeeqwei rfeellsaet dtpllppyls sslpspgely avqvkhvvsp
     1501 nevyicldsi etsnqsnqhs dtddsgvsge sesesldeal qrvnkkveal ppltdfrtem
     1561 pclaeyddgl wyrakivaik efnplsilvq fvdygstakl tlnrlcqips hlmryparai
     1621 kvllagfkpp lrdlgetrip ycpkwsmeal wamidclqgk qlyavsmapa peqivtlydd
     1681 eqhpvhmplv emgladkde
//
LOCUS       XP_011533458            1699 aa            linear   PRI 05-AUG-2025
DEFINITION  RING finger protein 17 isoform X1 [Homo sapiens].
ACCESSION   XP_011533458
VERSION     XP_011533458.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535156.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1699
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1699
                     /product="RING finger protein 17 isoform X1"
                     /calculated_mol_wt=193173
     Region          <74..101
                     /region_name="RING_Ubox"
                     /note="RING finger (Really Interesting New Gene) domain
                     and U-box domain superfamily; cl17238"
                     /db_xref="CDD:473075"
     Region          492..568
                     /region_name="Tudor_TDRD4_rpt1"
                     /note="first Tudor domain found in Tudor domain-containing
                     protein 4 (TDRD4) and similar proteins; cd20414"
                     /db_xref="CDD:410485"
     Site            order(501,508,544,547,549)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410485"
     Region          730..874
                     /region_name="Tudor_TDRD4_rpt2"
                     /note="second Tudor domain found in Tudor
                     domain-containing protein 4 (TDRD4) and similar proteins;
                     cd20415"
                     /db_xref="CDD:410486"
     Site            order(764,770,836,839,841)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410486"
     Region          1021..1102
                     /region_name="Tudor_TDRD4_rpt3"
                     /note="third Tudor domain found in Tudor domain-containing
                     protein 4 (TDRD4) and similar proteins; cd20416"
                     /db_xref="CDD:410487"
     Site            order(1049,1056,1073,1076,1078)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410487"
     Region          1305..1372
                     /region_name="Tudor_TDRD4_rpt4"
                     /note="fourth Tudor domain found in Tudor
                     domain-containing protein 4 (TDRD4) and similar proteins;
                     cd20417"
                     /db_xref="CDD:410488"
     Site            order(1315,1321,1337,1340,1342)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410488"
     Region          1553..1657
                     /region_name="Tudor_TDRD4_rpt5"
                     /note="fifth Tudor domain found in Tudor domain-containing
                     protein 4 (TDRD4) and similar proteins; cd20418"
                     /db_xref="CDD:410489"
     Site            order(1566,1572,1591,1594,1596)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410489"
     CDS             1..1699
                     /gene="RNF17"
                     /gene_synonym="Mmip-2; SPATA23; TDRD4"
                     /coded_by="XM_011535156.3:1754..6853"
                     /db_xref="GeneID:56163"
                     /db_xref="HGNC:HGNC:10060"
                     /db_xref="MIM:605793"
ORIGIN      
        1 mkasfhnekg lasndwslpr gppglalggc srrkrqrwrq rlrrlgllgl ptsewggrvs
       61 pgvplkssap ghhcelqcgh afcelcllmt eecttiicpd cevatavntr qryypmagyi
      121 kedsimeklq pktikncsqd fkktadqltt glersastdk tllnssavml dtntaeeide
      181 alntahhsfe qlsiagkale hmqkqtieer ervievvekq fdqllaffds rkknlceefa
      241 rttddylsnl ikaksyieek knnlnaamni aralqlspsl rtycdlnqii rtlqltsdse
      301 laqvsspqlr npprlsvncs eiicmfnnmg kiefrdstkc ypqeneirqn vqkkynnkke
      361 lscydtyppl ekkkvdmsvl tseapppplq petndvhlea knfqpqkdva taspktiavl
      421 pqmgsspdvi ieeiiednve ssaelvfvsh vidpchfyir kysqikdakv lekkvnefcn
      481 rsshldpsdi lelgarifvs sikngmwcrg titelipieg rntrkpcspt rlfvhevali
      541 qifmvdfgns evlivtgvvd thvrpehsak qhialndlcl vlrksepyte gllkdiqpla
      601 qpcslkdivp qnsnegweee akveflkmvn nkavsmkvfr eedgvlivdl qkpppnkiss
      661 dmpvslrdal vfmelakfks qslrshfekn ttlhyhppil pkemtdvsvt vchinspgdf
      721 ylqliegldi lfllktieef yksedgenle ilcpvqdqac vakfedgiwy rakvielnhw
      781 escwkscidr tkqqkliiqk pvnsslmltv clshailivk vqikglpghq evevkyvdfg
      841 ntakitikdv rkikdeflna pekaikckla yiepykrtmq wskeakekfe ekaqdkfmtc
      901 svikilednv llvelfdslg apemtttsin dqlvkeglas yeigyilkdn sqkhievwdp
      961 speeiisnev hnlnpvsaks lpnenfqsly nkelpvhicn vispekiyvq wlltenllns
     1021 leekmiaaye nskwepvkwe ndmhcavkiq dknqwrrgqi irmvtdtlve vllydvgvel
     1081 vvnvdclrkl eenlktmgrl slecslvdir paggsdkwta tacdclslyl tgavatiilq
     1141 vdseennttw plpvkifcrd ekgervdvsk ylikkglalr errinnldns hslsekslev
     1201 pleqedsvvt nciktnfdpd kktadiiseq kvsefqekil eprttrgykp paipnmnvfe
     1261 atvscvgddg tifvvpklse felikmtnei qsnlkclgll epyfwkkgea cavrgsdtlw
     1321 yrgkvmevvg gavrvqyldh gftekipqch lypillypdi pqfcipcqlh nttpvgnvwq
     1381 pdaievlqql lskrqvdihi melpknpwek lsihlyfdgm slsyfmayyk yctsehteem
     1441 lkekprsdhd kkyeeeqwei rfeellsaet dtpllppyls sslpspgely avqvkhvvsp
     1501 nevyicldsi etsnqsnqhs dtddsgvsge sesesldeal qrvnkkveal ppltdfrtem
     1561 pclaeyddgl wyrakivaik efnplsilvq fvdygstakl tlnrlcqips hlmryparai
     1621 kvllagfkpp lrdlgetrip ycpkwsmeal wamidclqgk qlyavsmapa peqivtlydd
     1681 eqhpvhmplv emgladkde
//
LOCUS       XP_011533457            1699 aa            linear   PRI 05-AUG-2025
DEFINITION  RING finger protein 17 isoform X1 [Homo sapiens].
ACCESSION   XP_011533457
VERSION     XP_011533457.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535155.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1699
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1699
                     /product="RING finger protein 17 isoform X1"
                     /calculated_mol_wt=193173
     Region          <74..101
                     /region_name="RING_Ubox"
                     /note="RING finger (Really Interesting New Gene) domain
                     and U-box domain superfamily; cl17238"
                     /db_xref="CDD:473075"
     Region          492..568
                     /region_name="Tudor_TDRD4_rpt1"
                     /note="first Tudor domain found in Tudor domain-containing
                     protein 4 (TDRD4) and similar proteins; cd20414"
                     /db_xref="CDD:410485"
     Site            order(501,508,544,547,549)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410485"
     Region          730..874
                     /region_name="Tudor_TDRD4_rpt2"
                     /note="second Tudor domain found in Tudor
                     domain-containing protein 4 (TDRD4) and similar proteins;
                     cd20415"
                     /db_xref="CDD:410486"
     Site            order(764,770,836,839,841)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410486"
     Region          1021..1102
                     /region_name="Tudor_TDRD4_rpt3"
                     /note="third Tudor domain found in Tudor domain-containing
                     protein 4 (TDRD4) and similar proteins; cd20416"
                     /db_xref="CDD:410487"
     Site            order(1049,1056,1073,1076,1078)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410487"
     Region          1305..1372
                     /region_name="Tudor_TDRD4_rpt4"
                     /note="fourth Tudor domain found in Tudor
                     domain-containing protein 4 (TDRD4) and similar proteins;
                     cd20417"
                     /db_xref="CDD:410488"
     Site            order(1315,1321,1337,1340,1342)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410488"
     Region          1553..1657
                     /region_name="Tudor_TDRD4_rpt5"
                     /note="fifth Tudor domain found in Tudor domain-containing
                     protein 4 (TDRD4) and similar proteins; cd20418"
                     /db_xref="CDD:410489"
     Site            order(1566,1572,1591,1594,1596)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410489"
     CDS             1..1699
                     /gene="RNF17"
                     /gene_synonym="Mmip-2; SPATA23; TDRD4"
                     /coded_by="XM_011535155.3:490..5589"
                     /db_xref="GeneID:56163"
                     /db_xref="HGNC:HGNC:10060"
                     /db_xref="MIM:605793"
ORIGIN      
        1 mkasfhnekg lasndwslpr gppglalggc srrkrqrwrq rlrrlgllgl ptsewggrvs
       61 pgvplkssap ghhcelqcgh afcelcllmt eecttiicpd cevatavntr qryypmagyi
      121 kedsimeklq pktikncsqd fkktadqltt glersastdk tllnssavml dtntaeeide
      181 alntahhsfe qlsiagkale hmqkqtieer ervievvekq fdqllaffds rkknlceefa
      241 rttddylsnl ikaksyieek knnlnaamni aralqlspsl rtycdlnqii rtlqltsdse
      301 laqvsspqlr npprlsvncs eiicmfnnmg kiefrdstkc ypqeneirqn vqkkynnkke
      361 lscydtyppl ekkkvdmsvl tseapppplq petndvhlea knfqpqkdva taspktiavl
      421 pqmgsspdvi ieeiiednve ssaelvfvsh vidpchfyir kysqikdakv lekkvnefcn
      481 rsshldpsdi lelgarifvs sikngmwcrg titelipieg rntrkpcspt rlfvhevali
      541 qifmvdfgns evlivtgvvd thvrpehsak qhialndlcl vlrksepyte gllkdiqpla
      601 qpcslkdivp qnsnegweee akveflkmvn nkavsmkvfr eedgvlivdl qkpppnkiss
      661 dmpvslrdal vfmelakfks qslrshfekn ttlhyhppil pkemtdvsvt vchinspgdf
      721 ylqliegldi lfllktieef yksedgenle ilcpvqdqac vakfedgiwy rakvielnhw
      781 escwkscidr tkqqkliiqk pvnsslmltv clshailivk vqikglpghq evevkyvdfg
      841 ntakitikdv rkikdeflna pekaikckla yiepykrtmq wskeakekfe ekaqdkfmtc
      901 svikilednv llvelfdslg apemtttsin dqlvkeglas yeigyilkdn sqkhievwdp
      961 speeiisnev hnlnpvsaks lpnenfqsly nkelpvhicn vispekiyvq wlltenllns
     1021 leekmiaaye nskwepvkwe ndmhcavkiq dknqwrrgqi irmvtdtlve vllydvgvel
     1081 vvnvdclrkl eenlktmgrl slecslvdir paggsdkwta tacdclslyl tgavatiilq
     1141 vdseennttw plpvkifcrd ekgervdvsk ylikkglalr errinnldns hslsekslev
     1201 pleqedsvvt nciktnfdpd kktadiiseq kvsefqekil eprttrgykp paipnmnvfe
     1261 atvscvgddg tifvvpklse felikmtnei qsnlkclgll epyfwkkgea cavrgsdtlw
     1321 yrgkvmevvg gavrvqyldh gftekipqch lypillypdi pqfcipcqlh nttpvgnvwq
     1381 pdaievlqql lskrqvdihi melpknpwek lsihlyfdgm slsyfmayyk yctsehteem
     1441 lkekprsdhd kkyeeeqwei rfeellsaet dtpllppyls sslpspgely avqvkhvvsp
     1501 nevyicldsi etsnqsnqhs dtddsgvsge sesesldeal qrvnkkveal ppltdfrtem
     1561 pclaeyddgl wyrakivaik efnplsilvq fvdygstakl tlnrlcqips hlmryparai
     1621 kvllagfkpp lrdlgetrip ycpkwsmeal wamidclqgk qlyavsmapa peqivtlydd
     1681 eqhpvhmplv emgladkde
//
LOCUS       XP_047286442            1699 aa            linear   PRI 05-AUG-2025
DEFINITION  RING finger protein 17 isoform X1 [Homo sapiens].
ACCESSION   XP_047286442
VERSION     XP_047286442.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430486.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1699
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1699
                     /product="RING finger protein 17 isoform X1"
                     /calculated_mol_wt=193173
     Region          <74..101
                     /region_name="RING_Ubox"
                     /note="RING finger (Really Interesting New Gene) domain
                     and U-box domain superfamily; cl17238"
                     /db_xref="CDD:473075"
     Region          492..568
                     /region_name="Tudor_TDRD4_rpt1"
                     /note="first Tudor domain found in Tudor domain-containing
                     protein 4 (TDRD4) and similar proteins; cd20414"
                     /db_xref="CDD:410485"
     Site            order(501,508,544,547,549)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410485"
     Region          730..874
                     /region_name="Tudor_TDRD4_rpt2"
                     /note="second Tudor domain found in Tudor
                     domain-containing protein 4 (TDRD4) and similar proteins;
                     cd20415"
                     /db_xref="CDD:410486"
     Site            order(764,770,836,839,841)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410486"
     Region          1021..1102
                     /region_name="Tudor_TDRD4_rpt3"
                     /note="third Tudor domain found in Tudor domain-containing
                     protein 4 (TDRD4) and similar proteins; cd20416"
                     /db_xref="CDD:410487"
     Site            order(1049,1056,1073,1076,1078)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410487"
     Region          1305..1372
                     /region_name="Tudor_TDRD4_rpt4"
                     /note="fourth Tudor domain found in Tudor
                     domain-containing protein 4 (TDRD4) and similar proteins;
                     cd20417"
                     /db_xref="CDD:410488"
     Site            order(1315,1321,1337,1340,1342)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410488"
     Region          1553..1657
                     /region_name="Tudor_TDRD4_rpt5"
                     /note="fifth Tudor domain found in Tudor domain-containing
                     protein 4 (TDRD4) and similar proteins; cd20418"
                     /db_xref="CDD:410489"
     Site            order(1566,1572,1591,1594,1596)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410489"
     CDS             1..1699
                     /gene="RNF17"
                     /gene_synonym="Mmip-2; SPATA23; TDRD4"
                     /coded_by="XM_047430486.1:447..5546"
                     /db_xref="GeneID:56163"
                     /db_xref="HGNC:HGNC:10060"
                     /db_xref="MIM:605793"
ORIGIN      
        1 mkasfhnekg lasndwslpr gppglalggc srrkrqrwrq rlrrlgllgl ptsewggrvs
       61 pgvplkssap ghhcelqcgh afcelcllmt eecttiicpd cevatavntr qryypmagyi
      121 kedsimeklq pktikncsqd fkktadqltt glersastdk tllnssavml dtntaeeide
      181 alntahhsfe qlsiagkale hmqkqtieer ervievvekq fdqllaffds rkknlceefa
      241 rttddylsnl ikaksyieek knnlnaamni aralqlspsl rtycdlnqii rtlqltsdse
      301 laqvsspqlr npprlsvncs eiicmfnnmg kiefrdstkc ypqeneirqn vqkkynnkke
      361 lscydtyppl ekkkvdmsvl tseapppplq petndvhlea knfqpqkdva taspktiavl
      421 pqmgsspdvi ieeiiednve ssaelvfvsh vidpchfyir kysqikdakv lekkvnefcn
      481 rsshldpsdi lelgarifvs sikngmwcrg titelipieg rntrkpcspt rlfvhevali
      541 qifmvdfgns evlivtgvvd thvrpehsak qhialndlcl vlrksepyte gllkdiqpla
      601 qpcslkdivp qnsnegweee akveflkmvn nkavsmkvfr eedgvlivdl qkpppnkiss
      661 dmpvslrdal vfmelakfks qslrshfekn ttlhyhppil pkemtdvsvt vchinspgdf
      721 ylqliegldi lfllktieef yksedgenle ilcpvqdqac vakfedgiwy rakvielnhw
      781 escwkscidr tkqqkliiqk pvnsslmltv clshailivk vqikglpghq evevkyvdfg
      841 ntakitikdv rkikdeflna pekaikckla yiepykrtmq wskeakekfe ekaqdkfmtc
      901 svikilednv llvelfdslg apemtttsin dqlvkeglas yeigyilkdn sqkhievwdp
      961 speeiisnev hnlnpvsaks lpnenfqsly nkelpvhicn vispekiyvq wlltenllns
     1021 leekmiaaye nskwepvkwe ndmhcavkiq dknqwrrgqi irmvtdtlve vllydvgvel
     1081 vvnvdclrkl eenlktmgrl slecslvdir paggsdkwta tacdclslyl tgavatiilq
     1141 vdseennttw plpvkifcrd ekgervdvsk ylikkglalr errinnldns hslsekslev
     1201 pleqedsvvt nciktnfdpd kktadiiseq kvsefqekil eprttrgykp paipnmnvfe
     1261 atvscvgddg tifvvpklse felikmtnei qsnlkclgll epyfwkkgea cavrgsdtlw
     1321 yrgkvmevvg gavrvqyldh gftekipqch lypillypdi pqfcipcqlh nttpvgnvwq
     1381 pdaievlqql lskrqvdihi melpknpwek lsihlyfdgm slsyfmayyk yctsehteem
     1441 lkekprsdhd kkyeeeqwei rfeellsaet dtpllppyls sslpspgely avqvkhvvsp
     1501 nevyicldsi etsnqsnqhs dtddsgvsge sesesldeal qrvnkkveal ppltdfrtem
     1561 pclaeyddgl wyrakivaik efnplsilvq fvdygstakl tlnrlcqips hlmryparai
     1621 kvllagfkpp lrdlgetrip ycpkwsmeal wamidclqgk qlyavsmapa peqivtlydd
     1681 eqhpvhmplv emgladkde
//
LOCUS       XP_011533459            1695 aa            linear   PRI 05-AUG-2025
DEFINITION  RING finger protein 17 isoform X2 [Homo sapiens].
ACCESSION   XP_011533459
VERSION     XP_011533459.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535157.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1695
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1695
                     /product="RING finger protein 17 isoform X2"
                     /calculated_mol_wt=192742
     Region          <74..101
                     /region_name="RING_Ubox"
                     /note="RING finger (Really Interesting New Gene) domain
                     and U-box domain superfamily; cl17238"
                     /db_xref="CDD:473075"
     Region          492..568
                     /region_name="Tudor_TDRD4_rpt1"
                     /note="first Tudor domain found in Tudor domain-containing
                     protein 4 (TDRD4) and similar proteins; cd20414"
                     /db_xref="CDD:410485"
     Site            order(501,508,544,547,549)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410485"
     Region          730..874
                     /region_name="Tudor_TDRD4_rpt2"
                     /note="second Tudor domain found in Tudor
                     domain-containing protein 4 (TDRD4) and similar proteins;
                     cd20415"
                     /db_xref="CDD:410486"
     Site            order(764,770,836,839,841)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410486"
     Region          1021..1102
                     /region_name="Tudor_TDRD4_rpt3"
                     /note="third Tudor domain found in Tudor domain-containing
                     protein 4 (TDRD4) and similar proteins; cd20416"
                     /db_xref="CDD:410487"
     Site            order(1049,1056,1073,1076,1078)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410487"
     Region          1301..1368
                     /region_name="Tudor_TDRD4_rpt4"
                     /note="fourth Tudor domain found in Tudor
                     domain-containing protein 4 (TDRD4) and similar proteins;
                     cd20417"
                     /db_xref="CDD:410488"
     Site            order(1311,1317,1333,1336,1338)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410488"
     Region          1549..1653
                     /region_name="Tudor_TDRD4_rpt5"
                     /note="fifth Tudor domain found in Tudor domain-containing
                     protein 4 (TDRD4) and similar proteins; cd20418"
                     /db_xref="CDD:410489"
     Site            order(1562,1568,1587,1590,1592)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410489"
     CDS             1..1695
                     /gene="RNF17"
                     /gene_synonym="Mmip-2; SPATA23; TDRD4"
                     /coded_by="XM_011535157.3:1754..6841"
                     /db_xref="GeneID:56163"
                     /db_xref="HGNC:HGNC:10060"
                     /db_xref="MIM:605793"
ORIGIN      
        1 mkasfhnekg lasndwslpr gppglalggc srrkrqrwrq rlrrlgllgl ptsewggrvs
       61 pgvplkssap ghhcelqcgh afcelcllmt eecttiicpd cevatavntr qryypmagyi
      121 kedsimeklq pktikncsqd fkktadqltt glersastdk tllnssavml dtntaeeide
      181 alntahhsfe qlsiagkale hmqkqtieer ervievvekq fdqllaffds rkknlceefa
      241 rttddylsnl ikaksyieek knnlnaamni aralqlspsl rtycdlnqii rtlqltsdse
      301 laqvsspqlr npprlsvncs eiicmfnnmg kiefrdstkc ypqeneirqn vqkkynnkke
      361 lscydtyppl ekkkvdmsvl tseapppplq petndvhlea knfqpqkdva taspktiavl
      421 pqmgsspdvi ieeiiednve ssaelvfvsh vidpchfyir kysqikdakv lekkvnefcn
      481 rsshldpsdi lelgarifvs sikngmwcrg titelipieg rntrkpcspt rlfvhevali
      541 qifmvdfgns evlivtgvvd thvrpehsak qhialndlcl vlrksepyte gllkdiqpla
      601 qpcslkdivp qnsnegweee akveflkmvn nkavsmkvfr eedgvlivdl qkpppnkiss
      661 dmpvslrdal vfmelakfks qslrshfekn ttlhyhppil pkemtdvsvt vchinspgdf
      721 ylqliegldi lfllktieef yksedgenle ilcpvqdqac vakfedgiwy rakvielnhw
      781 escwkscidr tkqqkliiqk pvnsslmltv clshailivk vqikglpghq evevkyvdfg
      841 ntakitikdv rkikdeflna pekaikckla yiepykrtmq wskeakekfe ekaqdkfmtc
      901 svikilednv llvelfdslg apemtttsin dqlvkeglas yeigyilkdn sqkhievwdp
      961 speeiisnev hnlnpvsaks lpnenfqsly nkelpvhicn vispekiyvq wlltenllns
     1021 leekmiaaye nskwepvkwe ndmhcavkiq dknqwrrgqi irmvtdtlve vllydvgvel
     1081 vvnvdclrkl eenlktmgrl slecslvdir paggsdkwta tacdclslyl tgavatiilq
     1141 ennttwplpv kifcrdekge rvdvskylik kglalrerri nnldnshsls ekslevpleq
     1201 edsvvtncik tnfdpdkkta diiseqkvse fqekileprt trgykppaip nmnvfeatvs
     1261 cvgddgtifv vpklsefeli kmtneiqsnl kclgllepyf wkkgeacavr gsdtlwyrgk
     1321 vmevvggavr vqyldhgfte kipqchlypi llypdipqfc ipcqlhnttp vgnvwqpdai
     1381 evlqqllskr qvdihimelp knpweklsih lyfdgmslsy fmayykycts ehteemlkek
     1441 prsdhdkkye eeqweirfee llsaetdtpl lppylssslp spgelyavqv khvvspnevy
     1501 icldsietsn qsnqhsdtdd sgvsgesese sldealqrvn kkvealpplt dfrtempcla
     1561 eyddglwyra kivaikefnp lsilvqfvdy gstakltlnr lcqipshlmr yparaikvll
     1621 agfkpplrdl getripycpk wsmealwami dclqgkqlya vsmapapeqi vtlyddeqhp
     1681 vhmplvemgl adkde
//
LOCUS       XP_006719909            1692 aa            linear   PRI 05-AUG-2025
DEFINITION  RING finger protein 17 isoform X3 [Homo sapiens].
ACCESSION   XP_006719909
VERSION     XP_006719909.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006719846.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1692
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1692
                     /product="RING finger protein 17 isoform X3"
                     /calculated_mol_wt=192376
     Region          <67..94
                     /region_name="RING_Ubox"
                     /note="RING finger (Really Interesting New Gene) domain
                     and U-box domain superfamily; cl17238"
                     /db_xref="CDD:473075"
     Region          485..561
                     /region_name="Tudor_TDRD4_rpt1"
                     /note="first Tudor domain found in Tudor domain-containing
                     protein 4 (TDRD4) and similar proteins; cd20414"
                     /db_xref="CDD:410485"
     Site            order(494,501,537,540,542)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410485"
     Region          723..867
                     /region_name="Tudor_TDRD4_rpt2"
                     /note="second Tudor domain found in Tudor
                     domain-containing protein 4 (TDRD4) and similar proteins;
                     cd20415"
                     /db_xref="CDD:410486"
     Site            order(757,763,829,832,834)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410486"
     Region          1014..1095
                     /region_name="Tudor_TDRD4_rpt3"
                     /note="third Tudor domain found in Tudor domain-containing
                     protein 4 (TDRD4) and similar proteins; cd20416"
                     /db_xref="CDD:410487"
     Site            order(1042,1049,1066,1069,1071)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410487"
     Region          1298..1365
                     /region_name="Tudor_TDRD4_rpt4"
                     /note="fourth Tudor domain found in Tudor
                     domain-containing protein 4 (TDRD4) and similar proteins;
                     cd20417"
                     /db_xref="CDD:410488"
     Site            order(1308,1314,1330,1333,1335)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410488"
     Region          1546..1650
                     /region_name="Tudor_TDRD4_rpt5"
                     /note="fifth Tudor domain found in Tudor domain-containing
                     protein 4 (TDRD4) and similar proteins; cd20418"
                     /db_xref="CDD:410489"
     Site            order(1559,1565,1584,1587,1589)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410489"
     CDS             1..1692
                     /gene="RNF17"
                     /gene_synonym="Mmip-2; SPATA23; TDRD4"
                     /coded_by="XM_006719846.4:36..5114"
                     /db_xref="GeneID:56163"
                     /db_xref="HGNC:HGNC:10060"
                     /db_xref="MIM:605793"
ORIGIN      
        1 maaeasktgp srssyqrmgr ksqpwgaaei qctrcgrrvs rssgeepkgp psgeaawrer
       61 wgpghhcelq cghafcelcl lmteecttii cpdcevatav ntrqryypma gyikedsime
      121 klqpktiknc sqdfkktadq lttglersas tdktllnssa vmldtntaee idealntahh
      181 sfeqlsiagk alehmqkqti eerervievv ekqfdqllaf fdsrkknlce efarttddyl
      241 snlikaksyi eekknnlnaa mniaralqls pslrtycdln qiirtlqlts dselaqvssp
      301 qlrnpprlsv ncseiicmfn nmgkiefrds tkcypqenei rqnvqkkynn kkelscydty
      361 pplekkkvdm svltseappp plqpetndvh leaknfqpqk dvataspkti avlpqmgssp
      421 dviieeiied nvessaelvf vshvidpchf yirkysqikd akvlekkvne fcnrsshldp
      481 sdilelgari fvssikngmw crgtitelip iegrntrkpc sptrlfvhev aliqifmvdf
      541 gnsevlivtg vvdthvrpeh sakqhialnd lclvlrksep ytegllkdiq plaqpcslkd
      601 ivpqnsnegw eeeakveflk mvnnkavsmk vfreedgvli vdlqkpppnk issdmpvslr
      661 dalvfmelak fksqslrshf eknttlhyhp pilpkemtdv svtvchinsp gdfylqlieg
      721 ldilfllkti eefyksedge nleilcpvqd qacvakfedg iwyrakviel nhwescwksc
      781 idrtkqqkli iqkpvnsslm ltvclshail ivkvqikglp ghqevevkyv dfgntakiti
      841 kdvrkikdef lnapekaikc klayiepykr tmqwskeake kfeekaqdkf mtcsvikile
      901 dnvllvelfd slgapemttt sindqlvkeg lasyeigyil kdnsqkhiev wdpspeeiis
      961 nevhnlnpvs akslpnenfq slynkelpvh icnvispeki yvqwlltenl lnsleekmia
     1021 ayenskwepv kwendmhcav kiqdknqwrr gqiirmvtdt lvevllydvg velvvnvdcl
     1081 rkleenlktm grlslecslv dirpaggsdk wtatacdcls lyltgavati ilqvdseenn
     1141 ttwplpvkif crdekgervd vskylikkgl alrerrinnl dnshslseks levpleqeds
     1201 vvtnciktnf dpdkktadii seqkvsefqe kileprttrg ykppaipnmn vfeatvscvg
     1261 ddgtifvvpk lsefelikmt neiqsnlkcl gllepyfwkk geacavrgsd tlwyrgkvme
     1321 vvggavrvqy ldhgftekip qchlypilly pdipqfcipc qlhnttpvgn vwqpdaievl
     1381 qqllskrqvd ihimelpknp weklsihlyf dgmslsyfma yykyctseht eemlkekprs
     1441 dhdkkyeeeq weirfeells aetdtpllpp ylssslpspg elyavqvkhv vspnevyicl
     1501 dsietsnqsn qhsdtddsgv sgesesesld ealqrvnkkv ealppltdfr tempclaeyd
     1561 dglwyrakiv aikefnplsi lvqfvdygst akltlnrlcq ipshlmrypa raikvllagf
     1621 kpplrdlget ripycpkwsm ealwamidcl qgkqlyavsm apapeqivtl yddeqhpvhm
     1681 plvemgladk de
//
LOCUS       XP_006719912            1672 aa            linear   PRI 05-AUG-2025
DEFINITION  RING finger protein 17 isoform X4 [Homo sapiens].
ACCESSION   XP_006719912
VERSION     XP_006719912.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006719849.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1672
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1672
                     /product="RING finger protein 17 isoform X4"
                     /calculated_mol_wt=190200
     Region          <47..74
                     /region_name="RING_Ubox"
                     /note="RING finger (Really Interesting New Gene) domain
                     and U-box domain superfamily; cl17238"
                     /db_xref="CDD:473075"
     Region          465..541
                     /region_name="Tudor_TDRD4_rpt1"
                     /note="first Tudor domain found in Tudor domain-containing
                     protein 4 (TDRD4) and similar proteins; cd20414"
                     /db_xref="CDD:410485"
     Site            order(474,481,517,520,522)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410485"
     Region          703..847
                     /region_name="Tudor_TDRD4_rpt2"
                     /note="second Tudor domain found in Tudor
                     domain-containing protein 4 (TDRD4) and similar proteins;
                     cd20415"
                     /db_xref="CDD:410486"
     Site            order(737,743,809,812,814)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410486"
     Region          994..1075
                     /region_name="Tudor_TDRD4_rpt3"
                     /note="third Tudor domain found in Tudor domain-containing
                     protein 4 (TDRD4) and similar proteins; cd20416"
                     /db_xref="CDD:410487"
     Site            order(1022,1029,1046,1049,1051)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410487"
     Region          1278..1345
                     /region_name="Tudor_TDRD4_rpt4"
                     /note="fourth Tudor domain found in Tudor
                     domain-containing protein 4 (TDRD4) and similar proteins;
                     cd20417"
                     /db_xref="CDD:410488"
     Site            order(1288,1294,1310,1313,1315)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410488"
     Region          1526..1630
                     /region_name="Tudor_TDRD4_rpt5"
                     /note="fifth Tudor domain found in Tudor domain-containing
                     protein 4 (TDRD4) and similar proteins; cd20418"
                     /db_xref="CDD:410489"
     Site            order(1539,1545,1564,1567,1569)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410489"
     CDS             1..1672
                     /gene="RNF17"
                     /gene_synonym="Mmip-2; SPATA23; TDRD4"
                     /coded_by="XM_006719849.3:36..5054"
                     /db_xref="GeneID:56163"
                     /db_xref="HGNC:HGNC:10060"
                     /db_xref="MIM:605793"
ORIGIN      
        1 maaeasktgp srssyqrmgr ksqpwgaaei qctrcgrrvs rssghhcelq cghafcelcl
       61 lmteecttii cpdcevatav ntrqryypma gyikedsime klqpktiknc sqdfkktadq
      121 lttglersas tdktllnssa vmldtntaee idealntahh sfeqlsiagk alehmqkqti
      181 eerervievv ekqfdqllaf fdsrkknlce efarttddyl snlikaksyi eekknnlnaa
      241 mniaralqls pslrtycdln qiirtlqlts dselaqvssp qlrnpprlsv ncseiicmfn
      301 nmgkiefrds tkcypqenei rqnvqkkynn kkelscydty pplekkkvdm svltseappp
      361 plqpetndvh leaknfqpqk dvataspkti avlpqmgssp dviieeiied nvessaelvf
      421 vshvidpchf yirkysqikd akvlekkvne fcnrsshldp sdilelgari fvssikngmw
      481 crgtitelip iegrntrkpc sptrlfvhev aliqifmvdf gnsevlivtg vvdthvrpeh
      541 sakqhialnd lclvlrksep ytegllkdiq plaqpcslkd ivpqnsnegw eeeakveflk
      601 mvnnkavsmk vfreedgvli vdlqkpppnk issdmpvslr dalvfmelak fksqslrshf
      661 eknttlhyhp pilpkemtdv svtvchinsp gdfylqlieg ldilfllkti eefyksedge
      721 nleilcpvqd qacvakfedg iwyrakviel nhwescwksc idrtkqqkli iqkpvnsslm
      781 ltvclshail ivkvqikglp ghqevevkyv dfgntakiti kdvrkikdef lnapekaikc
      841 klayiepykr tmqwskeake kfeekaqdkf mtcsvikile dnvllvelfd slgapemttt
      901 sindqlvkeg lasyeigyil kdnsqkhiev wdpspeeiis nevhnlnpvs akslpnenfq
      961 slynkelpvh icnvispeki yvqwlltenl lnsleekmia ayenskwepv kwendmhcav
     1021 kiqdknqwrr gqiirmvtdt lvevllydvg velvvnvdcl rkleenlktm grlslecslv
     1081 dirpaggsdk wtatacdcls lyltgavati ilqvdseenn ttwplpvkif crdekgervd
     1141 vskylikkgl alrerrinnl dnshslseks levpleqeds vvtnciktnf dpdkktadii
     1201 seqkvsefqe kileprttrg ykppaipnmn vfeatvscvg ddgtifvvpk lsefelikmt
     1261 neiqsnlkcl gllepyfwkk geacavrgsd tlwyrgkvme vvggavrvqy ldhgftekip
     1321 qchlypilly pdipqfcipc qlhnttpvgn vwqpdaievl qqllskrqvd ihimelpknp
     1381 weklsihlyf dgmslsyfma yykyctseht eemlkekprs dhdkkyeeeq weirfeells
     1441 aetdtpllpp ylssslpspg elyavqvkhv vspnevyicl dsietsnqsn qhsdtddsgv
     1501 sgesesesld ealqrvnkkv ealppltdfr tempclaeyd dglwyrakiv aikefnplsi
     1561 lvqfvdygst akltlnrlcq ipshlmrypa raikvllagf kpplrdlget ripycpkwsm
     1621 ealwamidcl qgkqlyavsm apapeqivtl yddeqhpvhm plvemgladk de
//
LOCUS       XP_011533460            1657 aa            linear   PRI 05-AUG-2025
DEFINITION  RING finger protein 17 isoform X5 [Homo sapiens].
ACCESSION   XP_011533460
VERSION     XP_011533460.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535158.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1657
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1657
                     /product="RING finger protein 17 isoform X5"
                     /calculated_mol_wt=188037
     Region          <74..101
                     /region_name="RING_Ubox"
                     /note="RING finger (Really Interesting New Gene) domain
                     and U-box domain superfamily; cl17238"
                     /db_xref="CDD:473075"
     Region          492..568
                     /region_name="Tudor_TDRD4_rpt1"
                     /note="first Tudor domain found in Tudor domain-containing
                     protein 4 (TDRD4) and similar proteins; cd20414"
                     /db_xref="CDD:410485"
     Site            order(501,508,544,547,549)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410485"
     Region          730..874
                     /region_name="Tudor_TDRD4_rpt2"
                     /note="second Tudor domain found in Tudor
                     domain-containing protein 4 (TDRD4) and similar proteins;
                     cd20415"
                     /db_xref="CDD:410486"
     Site            order(764,770,836,839,841)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410486"
     Region          1021..1102
                     /region_name="Tudor_TDRD4_rpt3"
                     /note="third Tudor domain found in Tudor domain-containing
                     protein 4 (TDRD4) and similar proteins; cd20416"
                     /db_xref="CDD:410487"
     Site            order(1049,1056,1073,1076,1078)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410487"
     Region          1305..1372
                     /region_name="Tudor_TDRD4_rpt4"
                     /note="fourth Tudor domain found in Tudor
                     domain-containing protein 4 (TDRD4) and similar proteins;
                     cd20417"
                     /db_xref="CDD:410488"
     Site            order(1315,1321,1337,1340,1342)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410488"
     Region          1511..1615
                     /region_name="Tudor_TDRD4_rpt5"
                     /note="fifth Tudor domain found in Tudor domain-containing
                     protein 4 (TDRD4) and similar proteins; cd20418"
                     /db_xref="CDD:410489"
     Site            order(1524,1530,1549,1552,1554)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410489"
     CDS             1..1657
                     /gene="RNF17"
                     /gene_synonym="Mmip-2; SPATA23; TDRD4"
                     /coded_by="XM_011535158.3:1754..6727"
                     /db_xref="GeneID:56163"
                     /db_xref="HGNC:HGNC:10060"
                     /db_xref="MIM:605793"
ORIGIN      
        1 mkasfhnekg lasndwslpr gppglalggc srrkrqrwrq rlrrlgllgl ptsewggrvs
       61 pgvplkssap ghhcelqcgh afcelcllmt eecttiicpd cevatavntr qryypmagyi
      121 kedsimeklq pktikncsqd fkktadqltt glersastdk tllnssavml dtntaeeide
      181 alntahhsfe qlsiagkale hmqkqtieer ervievvekq fdqllaffds rkknlceefa
      241 rttddylsnl ikaksyieek knnlnaamni aralqlspsl rtycdlnqii rtlqltsdse
      301 laqvsspqlr npprlsvncs eiicmfnnmg kiefrdstkc ypqeneirqn vqkkynnkke
      361 lscydtyppl ekkkvdmsvl tseapppplq petndvhlea knfqpqkdva taspktiavl
      421 pqmgsspdvi ieeiiednve ssaelvfvsh vidpchfyir kysqikdakv lekkvnefcn
      481 rsshldpsdi lelgarifvs sikngmwcrg titelipieg rntrkpcspt rlfvhevali
      541 qifmvdfgns evlivtgvvd thvrpehsak qhialndlcl vlrksepyte gllkdiqpla
      601 qpcslkdivp qnsnegweee akveflkmvn nkavsmkvfr eedgvlivdl qkpppnkiss
      661 dmpvslrdal vfmelakfks qslrshfekn ttlhyhppil pkemtdvsvt vchinspgdf
      721 ylqliegldi lfllktieef yksedgenle ilcpvqdqac vakfedgiwy rakvielnhw
      781 escwkscidr tkqqkliiqk pvnsslmltv clshailivk vqikglpghq evevkyvdfg
      841 ntakitikdv rkikdeflna pekaikckla yiepykrtmq wskeakekfe ekaqdkfmtc
      901 svikilednv llvelfdslg apemtttsin dqlvkeglas yeigyilkdn sqkhievwdp
      961 speeiisnev hnlnpvsaks lpnenfqsly nkelpvhicn vispekiyvq wlltenllns
     1021 leekmiaaye nskwepvkwe ndmhcavkiq dknqwrrgqi irmvtdtlve vllydvgvel
     1081 vvnvdclrkl eenlktmgrl slecslvdir paggsdkwta tacdclslyl tgavatiilq
     1141 vdseennttw plpvkifcrd ekgervdvsk ylikkglalr errinnldns hslsekslev
     1201 pleqedsvvt nciktnfdpd kktadiiseq kvsefqekil eprttrgykp paipnmnvfe
     1261 atvscvgddg tifvvpklse felikmtnei qsnlkclgll epyfwkkgea cavrgsdtlw
     1321 yrgkvmevvg gavrvqyldh gftekipqch lypillypdi pqfcipcqlh nttpvgnvwq
     1381 pdaievlqql lskrqvdihi mkprsdhdkk yeeeqweirf eellsaetdt pllppylsss
     1441 lpspgelyav qvkhvvspne vyicldsiet snqsnqhsdt ddsgvsgese sesldealqr
     1501 vnkkvealpp ltdfrtempc laeyddglwy rakivaikef nplsilvqfv dygstakltl
     1561 nrlcqipshl mryparaikv llagfkpplr dlgetripyc pkwsmealwa midclqgkql
     1621 yavsmapape qivtlyddeq hpvhmplvem gladkde
//
LOCUS       XP_011533461            1650 aa            linear   PRI 05-AUG-2025
DEFINITION  RING finger protein 17 isoform X6 [Homo sapiens].
ACCESSION   XP_011533461
VERSION     XP_011533461.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535159.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1650
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1650
                     /product="RING finger protein 17 isoform X6"
                     /calculated_mol_wt=187486
     Region          <74..101
                     /region_name="RING_Ubox"
                     /note="RING finger (Really Interesting New Gene) domain
                     and U-box domain superfamily; cl17238"
                     /db_xref="CDD:473075"
     Region          492..568
                     /region_name="Tudor_TDRD4_rpt1"
                     /note="first Tudor domain found in Tudor domain-containing
                     protein 4 (TDRD4) and similar proteins; cd20414"
                     /db_xref="CDD:410485"
     Site            order(501,508,544,547,549)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410485"
     Region          730..825
                     /region_name="Tudor_TDRD4_rpt2"
                     /note="second Tudor domain found in Tudor
                     domain-containing protein 4 (TDRD4) and similar proteins;
                     cd20415"
                     /db_xref="CDD:410486"
     Site            order(764,770,787,790,792)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410486"
     Region          972..1053
                     /region_name="Tudor_TDRD4_rpt3"
                     /note="third Tudor domain found in Tudor domain-containing
                     protein 4 (TDRD4) and similar proteins; cd20416"
                     /db_xref="CDD:410487"
     Site            order(1000,1007,1024,1027,1029)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410487"
     Region          1256..1323
                     /region_name="Tudor_TDRD4_rpt4"
                     /note="fourth Tudor domain found in Tudor
                     domain-containing protein 4 (TDRD4) and similar proteins;
                     cd20417"
                     /db_xref="CDD:410488"
     Site            order(1266,1272,1288,1291,1293)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410488"
     Region          1504..1608
                     /region_name="Tudor_TDRD4_rpt5"
                     /note="fifth Tudor domain found in Tudor domain-containing
                     protein 4 (TDRD4) and similar proteins; cd20418"
                     /db_xref="CDD:410489"
     Site            order(1517,1523,1542,1545,1547)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410489"
     CDS             1..1650
                     /gene="RNF17"
                     /gene_synonym="Mmip-2; SPATA23; TDRD4"
                     /coded_by="XM_011535159.3:1754..6706"
                     /db_xref="GeneID:56163"
                     /db_xref="HGNC:HGNC:10060"
                     /db_xref="MIM:605793"
ORIGIN      
        1 mkasfhnekg lasndwslpr gppglalggc srrkrqrwrq rlrrlgllgl ptsewggrvs
       61 pgvplkssap ghhcelqcgh afcelcllmt eecttiicpd cevatavntr qryypmagyi
      121 kedsimeklq pktikncsqd fkktadqltt glersastdk tllnssavml dtntaeeide
      181 alntahhsfe qlsiagkale hmqkqtieer ervievvekq fdqllaffds rkknlceefa
      241 rttddylsnl ikaksyieek knnlnaamni aralqlspsl rtycdlnqii rtlqltsdse
      301 laqvsspqlr npprlsvncs eiicmfnnmg kiefrdstkc ypqeneirqn vqkkynnkke
      361 lscydtyppl ekkkvdmsvl tseapppplq petndvhlea knfqpqkdva taspktiavl
      421 pqmgsspdvi ieeiiednve ssaelvfvsh vidpchfyir kysqikdakv lekkvnefcn
      481 rsshldpsdi lelgarifvs sikngmwcrg titelipieg rntrkpcspt rlfvhevali
      541 qifmvdfgns evlivtgvvd thvrpehsak qhialndlcl vlrksepyte gllkdiqpla
      601 qpcslkdivp qnsnegweee akveflkmvn nkavsmkvfr eedgvlivdl qkpppnkiss
      661 dmpvslrdal vfmelakfks qslrshfekn ttlhyhppil pkemtdvsvt vchinspgdf
      721 ylqliegldi lfllktieef yksedgenle ilcpvqdqac vakfedgiwy rakviglpgh
      781 qevevkyvdf gntakitikd vrkikdefln apekaikckl ayiepykrtm qwskeakekf
      841 eekaqdkfmt csvikiledn vllvelfdsl gapemtttsi ndqlvkegla syeigyilkd
      901 nsqkhievwd pspeeiisne vhnlnpvsak slpnenfqsl ynkelpvhic nvispekiyv
      961 qwlltenlln sleekmiaay enskwepvkw endmhcavki qdknqwrrgq iirmvtdtlv
     1021 evllydvgve lvvnvdclrk leenlktmgr lslecslvdi rpaggsdkwt atacdclsly
     1081 ltgavatiil qvdseenntt wplpvkifcr dekgervdvs kylikkglal rerrinnldn
     1141 shslseksle vpleqedsvv tnciktnfdp dkktadiise qkvsefqeki leprttrgyk
     1201 ppaipnmnvf eatvscvgdd gtifvvpkls efelikmtne iqsnlkclgl lepyfwkkge
     1261 acavrgsdtl wyrgkvmevv ggavrvqyld hgftekipqc hlypillypd ipqfcipcql
     1321 hnttpvgnvw qpdaievlqq llskrqvdih imelpknpwe klsihlyfdg mslsyfmayy
     1381 kyctsehtee mlkekprsdh dkkyeeeqwe irfeellsae tdtpllppyl ssslpspgel
     1441 yavqvkhvvs pnevyiclds ietsnqsnqh sdtddsgvsg esesesldea lqrvnkkvea
     1501 lppltdfrte mpclaeyddg lwyrakivai kefnplsilv qfvdygstak ltlnrlcqip
     1561 shlmrypara ikvllagfkp plrdlgetri pycpkwsmea lwamidclqg kqlyavsmap
     1621 apeqivtlyd deqhpvhmpl vemgladkde
//
LOCUS       XP_011533462            1646 aa            linear   PRI 05-AUG-2025
DEFINITION  RING finger protein 17 isoform X7 [Homo sapiens].
ACCESSION   XP_011533462
VERSION     XP_011533462.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535160.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1646
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1646
                     /product="RING finger protein 17 isoform X7"
                     /calculated_mol_wt=187055
     Region          <74..101
                     /region_name="RING_Ubox"
                     /note="RING finger (Really Interesting New Gene) domain
                     and U-box domain superfamily; cl17238"
                     /db_xref="CDD:473075"
     Region          492..568
                     /region_name="Tudor_TDRD4_rpt1"
                     /note="first Tudor domain found in Tudor domain-containing
                     protein 4 (TDRD4) and similar proteins; cd20414"
                     /db_xref="CDD:410485"
     Site            order(501,508,544,547,549)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410485"
     Region          730..825
                     /region_name="Tudor_TDRD4_rpt2"
                     /note="second Tudor domain found in Tudor
                     domain-containing protein 4 (TDRD4) and similar proteins;
                     cd20415"
                     /db_xref="CDD:410486"
     Site            order(764,770,787,790,792)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410486"
     Region          972..1053
                     /region_name="Tudor_TDRD4_rpt3"
                     /note="third Tudor domain found in Tudor domain-containing
                     protein 4 (TDRD4) and similar proteins; cd20416"
                     /db_xref="CDD:410487"
     Site            order(1000,1007,1024,1027,1029)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410487"
     Region          1252..1319
                     /region_name="Tudor_TDRD4_rpt4"
                     /note="fourth Tudor domain found in Tudor
                     domain-containing protein 4 (TDRD4) and similar proteins;
                     cd20417"
                     /db_xref="CDD:410488"
     Site            order(1262,1268,1284,1287,1289)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410488"
     Region          1500..1604
                     /region_name="Tudor_TDRD4_rpt5"
                     /note="fifth Tudor domain found in Tudor domain-containing
                     protein 4 (TDRD4) and similar proteins; cd20418"
                     /db_xref="CDD:410489"
     Site            order(1513,1519,1538,1541,1543)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410489"
     CDS             1..1646
                     /gene="RNF17"
                     /gene_synonym="Mmip-2; SPATA23; TDRD4"
                     /coded_by="XM_011535160.3:1754..6694"
                     /db_xref="GeneID:56163"
                     /db_xref="HGNC:HGNC:10060"
                     /db_xref="MIM:605793"
ORIGIN      
        1 mkasfhnekg lasndwslpr gppglalggc srrkrqrwrq rlrrlgllgl ptsewggrvs
       61 pgvplkssap ghhcelqcgh afcelcllmt eecttiicpd cevatavntr qryypmagyi
      121 kedsimeklq pktikncsqd fkktadqltt glersastdk tllnssavml dtntaeeide
      181 alntahhsfe qlsiagkale hmqkqtieer ervievvekq fdqllaffds rkknlceefa
      241 rttddylsnl ikaksyieek knnlnaamni aralqlspsl rtycdlnqii rtlqltsdse
      301 laqvsspqlr npprlsvncs eiicmfnnmg kiefrdstkc ypqeneirqn vqkkynnkke
      361 lscydtyppl ekkkvdmsvl tseapppplq petndvhlea knfqpqkdva taspktiavl
      421 pqmgsspdvi ieeiiednve ssaelvfvsh vidpchfyir kysqikdakv lekkvnefcn
      481 rsshldpsdi lelgarifvs sikngmwcrg titelipieg rntrkpcspt rlfvhevali
      541 qifmvdfgns evlivtgvvd thvrpehsak qhialndlcl vlrksepyte gllkdiqpla
      601 qpcslkdivp qnsnegweee akveflkmvn nkavsmkvfr eedgvlivdl qkpppnkiss
      661 dmpvslrdal vfmelakfks qslrshfekn ttlhyhppil pkemtdvsvt vchinspgdf
      721 ylqliegldi lfllktieef yksedgenle ilcpvqdqac vakfedgiwy rakviglpgh
      781 qevevkyvdf gntakitikd vrkikdefln apekaikckl ayiepykrtm qwskeakekf
      841 eekaqdkfmt csvikiledn vllvelfdsl gapemtttsi ndqlvkegla syeigyilkd
      901 nsqkhievwd pspeeiisne vhnlnpvsak slpnenfqsl ynkelpvhic nvispekiyv
      961 qwlltenlln sleekmiaay enskwepvkw endmhcavki qdknqwrrgq iirmvtdtlv
     1021 evllydvgve lvvnvdclrk leenlktmgr lslecslvdi rpaggsdkwt atacdclsly
     1081 ltgavatiil qennttwplp vkifcrdekg ervdvskyli kkglalrerr innldnshsl
     1141 sekslevple qedsvvtnci ktnfdpdkkt adiiseqkvs efqekilepr ttrgykppai
     1201 pnmnvfeatv scvgddgtif vvpklsefel ikmtneiqsn lkclgllepy fwkkgeacav
     1261 rgsdtlwyrg kvmevvggav rvqyldhgft ekipqchlyp illypdipqf cipcqlhntt
     1321 pvgnvwqpda ievlqqllsk rqvdihimel pknpweklsi hlyfdgmsls yfmayykyct
     1381 sehteemlke kprsdhdkky eeeqweirfe ellsaetdtp llppylsssl pspgelyavq
     1441 vkhvvspnev yicldsiets nqsnqhsdtd dsgvsgeses esldealqrv nkkvealppl
     1501 tdfrtempcl aeyddglwyr akivaikefn plsilvqfvd ygstakltln rlcqipshlm
     1561 ryparaikvl lagfkpplrd lgetripycp kwsmealwam idclqgkqly avsmapapeq
     1621 ivtlyddeqh pvhmplvemg ladkde
//
LOCUS       XP_016876165            1611 aa            linear   PRI 05-AUG-2025
DEFINITION  RING finger protein 17 isoform X8 [Homo sapiens].
ACCESSION   XP_016876165
VERSION     XP_016876165.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020676.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1611
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1611
                     /product="RING finger protein 17 isoform X8"
                     /calculated_mol_wt=183505
     Region          404..480
                     /region_name="Tudor_TDRD4_rpt1"
                     /note="first Tudor domain found in Tudor domain-containing
                     protein 4 (TDRD4) and similar proteins; cd20414"
                     /db_xref="CDD:410485"
     Site            order(413,420,456,459,461)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410485"
     Region          642..786
                     /region_name="Tudor_TDRD4_rpt2"
                     /note="second Tudor domain found in Tudor
                     domain-containing protein 4 (TDRD4) and similar proteins;
                     cd20415"
                     /db_xref="CDD:410486"
     Site            order(676,682,748,751,753)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410486"
     Region          933..1014
                     /region_name="Tudor_TDRD4_rpt3"
                     /note="third Tudor domain found in Tudor domain-containing
                     protein 4 (TDRD4) and similar proteins; cd20416"
                     /db_xref="CDD:410487"
     Site            order(961,968,985,988,990)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410487"
     Region          1217..1284
                     /region_name="Tudor_TDRD4_rpt4"
                     /note="fourth Tudor domain found in Tudor
                     domain-containing protein 4 (TDRD4) and similar proteins;
                     cd20417"
                     /db_xref="CDD:410488"
     Site            order(1227,1233,1249,1252,1254)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410488"
     Region          1465..1569
                     /region_name="Tudor_TDRD4_rpt5"
                     /note="fifth Tudor domain found in Tudor domain-containing
                     protein 4 (TDRD4) and similar proteins; cd20418"
                     /db_xref="CDD:410489"
     Site            order(1478,1484,1503,1506,1508)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410489"
     CDS             1..1611
                     /gene="RNF17"
                     /gene_synonym="Mmip-2; SPATA23; TDRD4"
                     /coded_by="XM_017020676.2:186..5021"
                     /db_xref="GeneID:56163"
                     /db_xref="HGNC:HGNC:10060"
                     /db_xref="MIM:605793"
ORIGIN      
        1 mteecttiic pdcevatavn trqryypmag yikedsimek lqpktikncs qdfkktadql
       61 ttglersast dktllnssav mldtntaeei dealntahhs feqlsiagka lehmqkqtie
      121 erervievve kqfdqllaff dsrkknlcee farttddyls nlikaksyie ekknnlnaam
      181 niaralqlsp slrtycdlnq iirtlqltsd selaqvsspq lrnpprlsvn cseiicmfnn
      241 mgkiefrdst kcypqeneir qnvqkkynnk kelscydtyp plekkkvdms vltseapppp
      301 lqpetndvhl eaknfqpqkd vataspktia vlpqmgsspd viieeiiedn vessaelvfv
      361 shvidpchfy irkysqikda kvlekkvnef cnrsshldps dilelgarif vssikngmwc
      421 rgtitelipi egrntrkpcs ptrlfvheva liqifmvdfg nsevlivtgv vdthvrpehs
      481 akqhialndl clvlrksepy tegllkdiqp laqpcslkdi vpqnsnegwe eeakveflkm
      541 vnnkavsmkv freedgvliv dlqkpppnki ssdmpvslrd alvfmelakf ksqslrshfe
      601 knttlhyhpp ilpkemtdvs vtvchinspg dfylqliegl dilfllktie efyksedgen
      661 leilcpvqdq acvakfedgi wyrakvieln hwescwksci drtkqqklii qkpvnsslml
      721 tvclshaili vkvqikglpg hqevevkyvd fgntakitik dvrkikdefl napekaikck
      781 layiepykrt mqwskeakek feekaqdkfm tcsvikiled nvllvelfds lgapemttts
      841 indqlvkegl asyeigyilk dnsqkhievw dpspeeiisn evhnlnpvsa kslpnenfqs
      901 lynkelpvhi cnvispekiy vqwlltenll nsleekmiaa yenskwepvk wendmhcavk
      961 iqdknqwrrg qiirmvtdtl vevllydvgv elvvnvdclr kleenlktmg rlslecslvd
     1021 irpaggsdkw tatacdclsl yltgavatii lqvdseennt twplpvkifc rdekgervdv
     1081 skylikkgla lrerrinnld nshslseksl evpleqedsv vtnciktnfd pdkktadiis
     1141 eqkvsefqek ileprttrgy kppaipnmnv featvscvgd dgtifvvpkl sefelikmtn
     1201 eiqsnlkclg llepyfwkkg eacavrgsdt lwyrgkvmev vggavrvqyl dhgftekipq
     1261 chlypillyp dipqfcipcq lhnttpvgnv wqpdaievlq qllskrqvdi himelpknpw
     1321 eklsihlyfd gmslsyfmay ykyctsehte emlkekprsd hdkkyeeeqw eirfeellsa
     1381 etdtpllppy lssslpspge lyavqvkhvv spnevyicld sietsnqsnq hsdtddsgvs
     1441 geseseslde alqrvnkkve alppltdfrt empclaeydd glwyrakiva ikefnplsil
     1501 vqfvdygsta kltlnrlcqi pshlmrypar aikvllagfk pplrdlgetr ipycpkwsme
     1561 alwamidclq gkqlyavsma papeqivtly ddeqhpvhmp lvemgladkd e
//
LOCUS       XP_047286444            1531 aa            linear   PRI 05-AUG-2025
DEFINITION  RING finger protein 17 isoform X9 [Homo sapiens].
ACCESSION   XP_047286444
VERSION     XP_047286444.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430488.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1531
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1531
                     /product="RING finger protein 17 isoform X9"
                     /calculated_mol_wt=174596
     Region          324..400
                     /region_name="Tudor_TDRD4_rpt1"
                     /note="first Tudor domain found in Tudor domain-containing
                     protein 4 (TDRD4) and similar proteins; cd20414"
                     /db_xref="CDD:410485"
     Site            order(333,340,376,379,381)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410485"
     Region          562..706
                     /region_name="Tudor_TDRD4_rpt2"
                     /note="second Tudor domain found in Tudor
                     domain-containing protein 4 (TDRD4) and similar proteins;
                     cd20415"
                     /db_xref="CDD:410486"
     Site            order(596,602,668,671,673)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410486"
     Region          853..934
                     /region_name="Tudor_TDRD4_rpt3"
                     /note="third Tudor domain found in Tudor domain-containing
                     protein 4 (TDRD4) and similar proteins; cd20416"
                     /db_xref="CDD:410487"
     Site            order(881,888,905,908,910)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410487"
     Region          1137..1204
                     /region_name="Tudor_TDRD4_rpt4"
                     /note="fourth Tudor domain found in Tudor
                     domain-containing protein 4 (TDRD4) and similar proteins;
                     cd20417"
                     /db_xref="CDD:410488"
     Site            order(1147,1153,1169,1172,1174)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410488"
     Region          1385..1489
                     /region_name="Tudor_TDRD4_rpt5"
                     /note="fifth Tudor domain found in Tudor domain-containing
                     protein 4 (TDRD4) and similar proteins; cd20418"
                     /db_xref="CDD:410489"
     Site            order(1398,1404,1423,1426,1428)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410489"
     CDS             1..1531
                     /gene="RNF17"
                     /gene_synonym="Mmip-2; SPATA23; TDRD4"
                     /coded_by="XM_047430488.1:188..4783"
                     /db_xref="GeneID:56163"
                     /db_xref="HGNC:HGNC:10060"
                     /db_xref="MIM:605793"
ORIGIN      
        1 mldtntaeei dealntahhs feqlsiagka lehmqkqtie erervievve kqfdqllaff
       61 dsrkknlcee farttddyls nlikaksyie ekknnlnaam niaralqlsp slrtycdlnq
      121 iirtlqltsd selaqvsspq lrnpprlsvn cseiicmfnn mgkiefrdst kcypqeneir
      181 qnvqkkynnk kelscydtyp plekkkvdms vltseapppp lqpetndvhl eaknfqpqkd
      241 vataspktia vlpqmgsspd viieeiiedn vessaelvfv shvidpchfy irkysqikda
      301 kvlekkvnef cnrsshldps dilelgarif vssikngmwc rgtitelipi egrntrkpcs
      361 ptrlfvheva liqifmvdfg nsevlivtgv vdthvrpehs akqhialndl clvlrksepy
      421 tegllkdiqp laqpcslkdi vpqnsnegwe eeakveflkm vnnkavsmkv freedgvliv
      481 dlqkpppnki ssdmpvslrd alvfmelakf ksqslrshfe knttlhyhpp ilpkemtdvs
      541 vtvchinspg dfylqliegl dilfllktie efyksedgen leilcpvqdq acvakfedgi
      601 wyrakvieln hwescwksci drtkqqklii qkpvnsslml tvclshaili vkvqikglpg
      661 hqevevkyvd fgntakitik dvrkikdefl napekaikck layiepykrt mqwskeakek
      721 feekaqdkfm tcsvikiled nvllvelfds lgapemttts indqlvkegl asyeigyilk
      781 dnsqkhievw dpspeeiisn evhnlnpvsa kslpnenfqs lynkelpvhi cnvispekiy
      841 vqwlltenll nsleekmiaa yenskwepvk wendmhcavk iqdknqwrrg qiirmvtdtl
      901 vevllydvgv elvvnvdclr kleenlktmg rlslecslvd irpaggsdkw tatacdclsl
      961 yltgavatii lqvdseennt twplpvkifc rdekgervdv skylikkgla lrerrinnld
     1021 nshslseksl evpleqedsv vtnciktnfd pdkktadiis eqkvsefqek ileprttrgy
     1081 kppaipnmnv featvscvgd dgtifvvpkl sefelikmtn eiqsnlkclg llepyfwkkg
     1141 eacavrgsdt lwyrgkvmev vggavrvqyl dhgftekipq chlypillyp dipqfcipcq
     1201 lhnttpvgnv wqpdaievlq qllskrqvdi himelpknpw eklsihlyfd gmslsyfmay
     1261 ykyctsehte emlkekprsd hdkkyeeeqw eirfeellsa etdtpllppy lssslpspge
     1321 lyavqvkhvv spnevyicld sietsnqsnq hsdtddsgvs geseseslde alqrvnkkve
     1381 alppltdfrt empclaeydd glwyrakiva ikefnplsil vqfvdygsta kltlnrlcqi
     1441 pshlmrypar aikvllagfk pplrdlgetr ipycpkwsme alwamidclq gkqlyavsma
     1501 papeqivtly ddeqhpvhmp lvemgladkd e
//
LOCUS       XP_011533464            1498 aa            linear   PRI 05-AUG-2025
DEFINITION  RING finger protein 17 isoform X10 [Homo sapiens].
ACCESSION   XP_011533464
VERSION     XP_011533464.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535162.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1498
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1498
                     /product="RING finger protein 17 isoform X10"
                     /calculated_mol_wt=170977
     Region          291..367
                     /region_name="Tudor_TDRD4_rpt1"
                     /note="first Tudor domain found in Tudor domain-containing
                     protein 4 (TDRD4) and similar proteins; cd20414"
                     /db_xref="CDD:410485"
     Site            order(300,307,343,346,348)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410485"
     Region          529..673
                     /region_name="Tudor_TDRD4_rpt2"
                     /note="second Tudor domain found in Tudor
                     domain-containing protein 4 (TDRD4) and similar proteins;
                     cd20415"
                     /db_xref="CDD:410486"
     Site            order(563,569,635,638,640)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410486"
     Region          820..901
                     /region_name="Tudor_TDRD4_rpt3"
                     /note="third Tudor domain found in Tudor domain-containing
                     protein 4 (TDRD4) and similar proteins; cd20416"
                     /db_xref="CDD:410487"
     Site            order(848,855,872,875,877)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410487"
     Region          1104..1171
                     /region_name="Tudor_TDRD4_rpt4"
                     /note="fourth Tudor domain found in Tudor
                     domain-containing protein 4 (TDRD4) and similar proteins;
                     cd20417"
                     /db_xref="CDD:410488"
     Site            order(1114,1120,1136,1139,1141)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410488"
     Region          1352..1456
                     /region_name="Tudor_TDRD4_rpt5"
                     /note="fifth Tudor domain found in Tudor domain-containing
                     protein 4 (TDRD4) and similar proteins; cd20418"
                     /db_xref="CDD:410489"
     Site            order(1365,1371,1390,1393,1395)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410489"
     CDS             1..1498
                     /gene="RNF17"
                     /gene_synonym="Mmip-2; SPATA23; TDRD4"
                     /coded_by="XM_011535162.2:99..4595"
                     /db_xref="GeneID:56163"
                     /db_xref="HGNC:HGNC:10060"
                     /db_xref="MIM:605793"
ORIGIN      
        1 mqkqtieere rvievvekqf dqllaffdsr kknlceefar ttddylsnli kaksyieekk
       61 nnlnaamnia ralqlspslr tycdlnqiir tlqltsdsel aqvsspqlrn pprlsvncse
      121 iicmfnnmgk iefrdstkcy pqeneirqnv qkkynnkkel scydtypple kkkvdmsvlt
      181 seapppplqp etndvhleak nfqpqkdvat aspktiavlp qmgsspdvii eeiiednves
      241 saelvfvshv idpchfyirk ysqikdakvl ekkvnefcnr sshldpsdil elgarifvss
      301 ikngmwcrgt itelipiegr ntrkpcsptr lfvhevaliq ifmvdfgnse vlivtgvvdt
      361 hvrpehsakq hialndlclv lrksepyteg llkdiqplaq pcslkdivpq nsnegweeea
      421 kveflkmvnn kavsmkvfre edgvlivdlq kpppnkissd mpvslrdalv fmelakfksq
      481 slrshfeknt tlhyhppilp kemtdvsvtv chinspgdfy lqliegldil fllktieefy
      541 ksedgenlei lcpvqdqacv akfedgiwyr akvielnhwe scwkscidrt kqqkliiqkp
      601 vnsslmltvc lshailivkv qikglpghqe vevkyvdfgn takitikdvr kikdeflnap
      661 ekaikcklay iepykrtmqw skeakekfee kaqdkfmtcs vikilednvl lvelfdslga
      721 pemtttsind qlvkeglasy eigyilkdns qkhievwdps peeiisnevh nlnpvsaksl
      781 pnenfqslyn kelpvhicnv ispekiyvqw lltenllnsl eekmiaayen skwepvkwen
      841 dmhcavkiqd knqwrrgqii rmvtdtlvev llydvgvelv vnvdclrkle enlktmgrls
      901 lecslvdirp aggsdkwtat acdclslylt gavatiilqv dseennttwp lpvkifcrde
      961 kgervdvsky likkglalre rrinnldnsh slsekslevp leqedsvvtn ciktnfdpdk
     1021 ktadiiseqk vsefqekile prttrgykpp aipnmnvfea tvscvgddgt ifvvpklsef
     1081 elikmtneiq snlkclglle pyfwkkgeac avrgsdtlwy rgkvmevvgg avrvqyldhg
     1141 ftekipqchl ypillypdip qfcipcqlhn ttpvgnvwqp daievlqqll skrqvdihim
     1201 elpknpwekl sihlyfdgms lsyfmayyky ctsehteeml kekprsdhdk kyeeeqweir
     1261 feellsaetd tpllppylss slpspgelya vqvkhvvspn evyicldsie tsnqsnqhsd
     1321 tddsgvsges esesldealq rvnkkvealp pltdfrtemp claeyddglw yrakivaike
     1381 fnplsilvqf vdygstaklt lnrlcqipsh lmryparaik vllagfkppl rdlgetripy
     1441 cpkwsmealw amidclqgkq lyavsmapap eqivtlydde qhpvhmplve mgladkde
//
LOCUS       XP_011533465            1261 aa            linear   PRI 05-AUG-2025
DEFINITION  RING finger protein 17 isoform X11 [Homo sapiens].
ACCESSION   XP_011533465
VERSION     XP_011533465.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535163.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1261
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1261
                     /product="RING finger protein 17 isoform X11"
                     /calculated_mol_wt=143796
     Region          54..130
                     /region_name="Tudor_TDRD4_rpt1"
                     /note="first Tudor domain found in Tudor domain-containing
                     protein 4 (TDRD4) and similar proteins; cd20414"
                     /db_xref="CDD:410485"
     Site            order(63,70,106,109,111)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410485"
     Region          292..436
                     /region_name="Tudor_TDRD4_rpt2"
                     /note="second Tudor domain found in Tudor
                     domain-containing protein 4 (TDRD4) and similar proteins;
                     cd20415"
                     /db_xref="CDD:410486"
     Site            order(326,332,398,401,403)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410486"
     Region          583..664
                     /region_name="Tudor_TDRD4_rpt3"
                     /note="third Tudor domain found in Tudor domain-containing
                     protein 4 (TDRD4) and similar proteins; cd20416"
                     /db_xref="CDD:410487"
     Site            order(611,618,635,638,640)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410487"
     Region          867..934
                     /region_name="Tudor_TDRD4_rpt4"
                     /note="fourth Tudor domain found in Tudor
                     domain-containing protein 4 (TDRD4) and similar proteins;
                     cd20417"
                     /db_xref="CDD:410488"
     Site            order(877,883,899,902,904)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410488"
     Region          1115..1219
                     /region_name="Tudor_TDRD4_rpt5"
                     /note="fifth Tudor domain found in Tudor domain-containing
                     protein 4 (TDRD4) and similar proteins; cd20418"
                     /db_xref="CDD:410489"
     Site            order(1128,1134,1153,1156,1158)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410489"
     CDS             1..1261
                     /gene="RNF17"
                     /gene_synonym="Mmip-2; SPATA23; TDRD4"
                     /coded_by="XM_011535163.2:80..3865"
                     /db_xref="GeneID:56163"
                     /db_xref="HGNC:HGNC:10060"
                     /db_xref="MIM:605793"
ORIGIN      
        1 mcssaelvfv shvidpchfy irkysqikda kvlekkvnef cnrsshldps dilelgarif
       61 vssikngmwc rgtitelipi egrntrkpcs ptrlfvheva liqifmvdfg nsevlivtgv
      121 vdthvrpehs akqhialndl clvlrksepy tegllkdiqp laqpcslkdi vpqnsnegwe
      181 eeakveflkm vnnkavsmkv freedgvliv dlqkpppnki ssdmpvslrd alvfmelakf
      241 ksqslrshfe knttlhyhpp ilpkemtdvs vtvchinspg dfylqliegl dilfllktie
      301 efyksedgen leilcpvqdq acvakfedgi wyrakvieln hwescwksci drtkqqklii
      361 qkpvnsslml tvclshaili vkvqikglpg hqevevkyvd fgntakitik dvrkikdefl
      421 napekaikck layiepykrt mqwskeakek feekaqdkfm tcsvikiled nvllvelfds
      481 lgapemttts indqlvkegl asyeigyilk dnsqkhievw dpspeeiisn evhnlnpvsa
      541 kslpnenfqs lynkelpvhi cnvispekiy vqwlltenll nsleekmiaa yenskwepvk
      601 wendmhcavk iqdknqwrrg qiirmvtdtl vevllydvgv elvvnvdclr kleenlktmg
      661 rlslecslvd irpaggsdkw tatacdclsl yltgavatii lqvdseennt twplpvkifc
      721 rdekgervdv skylikkgla lrerrinnld nshslseksl evpleqedsv vtnciktnfd
      781 pdkktadiis eqkvsefqek ileprttrgy kppaipnmnv featvscvgd dgtifvvpkl
      841 sefelikmtn eiqsnlkclg llepyfwkkg eacavrgsdt lwyrgkvmev vggavrvqyl
      901 dhgftekipq chlypillyp dipqfcipcq lhnttpvgnv wqpdaievlq qllskrqvdi
      961 himelpknpw eklsihlyfd gmslsyfmay ykyctsehte emlkekprsd hdkkyeeeqw
     1021 eirfeellsa etdtpllppy lssslpspge lyavqvkhvv spnevyicld sietsnqsnq
     1081 hsdtddsgvs geseseslde alqrvnkkve alppltdfrt empclaeydd glwyrakiva
     1141 ikefnplsil vqfvdygsta kltlnrlcqi pshlmrypar aikvllagfk pplrdlgetr
     1201 ipycpkwsme alwamidclq gkqlyavsma papeqivtly ddeqhpvhmp lvemgladkd
     1261 e
//
LOCUS       XP_011533466             889 aa            linear   PRI 05-AUG-2025
DEFINITION  RING finger protein 17 isoform X12 [Homo sapiens].
ACCESSION   XP_011533466
VERSION     XP_011533466.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535164.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..889
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..889
                     /product="RING finger protein 17 isoform X12"
                     /calculated_mol_wt=101418
     Region          <12..64
                     /region_name="Tudor_SF"
                     /note="Tudor domain superfamily; cl02573"
                     /db_xref="CDD:470623"
     Region          211..292
                     /region_name="Tudor_TDRD4_rpt3"
                     /note="third Tudor domain found in Tudor domain-containing
                     protein 4 (TDRD4) and similar proteins; cd20416"
                     /db_xref="CDD:410487"
     Site            order(239,246,263,266,268)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410487"
     Region          495..562
                     /region_name="Tudor_TDRD4_rpt4"
                     /note="fourth Tudor domain found in Tudor
                     domain-containing protein 4 (TDRD4) and similar proteins;
                     cd20417"
                     /db_xref="CDD:410488"
     Site            order(505,511,527,530,532)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410488"
     Region          743..847
                     /region_name="Tudor_TDRD4_rpt5"
                     /note="fifth Tudor domain found in Tudor domain-containing
                     protein 4 (TDRD4) and similar proteins; cd20418"
                     /db_xref="CDD:410489"
     Site            order(756,762,781,784,786)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410489"
     CDS             1..889
                     /gene="RNF17"
                     /gene_synonym="Mmip-2; SPATA23; TDRD4"
                     /coded_by="XM_011535164.3:92..2761"
                     /db_xref="GeneID:56163"
                     /db_xref="HGNC:HGNC:10060"
                     /db_xref="MIM:605793"
ORIGIN      
        1 mefgteqkls vqikglpghq evevkyvdfg ntakitikdv rkikdeflna pekaikckla
       61 yiepykrtmq wskeakekfe ekaqdkfmtc svikilednv llvelfdslg apemtttsin
      121 dqlvkeglas yeigyilkdn sqkhievwdp speeiisnev hnlnpvsaks lpnenfqsly
      181 nkelpvhicn vispekiyvq wlltenllns leekmiaaye nskwepvkwe ndmhcavkiq
      241 dknqwrrgqi irmvtdtlve vllydvgvel vvnvdclrkl eenlktmgrl slecslvdir
      301 paggsdkwta tacdclslyl tgavatiilq vdseennttw plpvkifcrd ekgervdvsk
      361 ylikkglalr errinnldns hslsekslev pleqedsvvt nciktnfdpd kktadiiseq
      421 kvsefqekil eprttrgykp paipnmnvfe atvscvgddg tifvvpklse felikmtnei
      481 qsnlkclgll epyfwkkgea cavrgsdtlw yrgkvmevvg gavrvqyldh gftekipqch
      541 lypillypdi pqfcipcqlh nttpvgnvwq pdaievlqql lskrqvdihi melpknpwek
      601 lsihlyfdgm slsyfmayyk yctsehteem lkekprsdhd kkyeeeqwei rfeellsaet
      661 dtpllppyls sslpspgely avqvkhvvsp nevyicldsi etsnqsnqhs dtddsgvsge
      721 sesesldeal qrvnkkveal ppltdfrtem pclaeyddgl wyrakivaik efnplsilvq
      781 fvdygstakl tlnrlcqips hlmryparai kvllagfkpp lrdlgetrip ycpkwsmeal
      841 wamidclqgk qlyavsmapa peqivtlydd eqhpvhmplv emgladkde
//
LOCUS       XP_011533470             702 aa            linear   PRI 05-AUG-2025
DEFINITION  conserved oligomeric Golgi complex subunit 6 isoform X1 [Homo
            sapiens].
ACCESSION   XP_011533470
VERSION     XP_011533470.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535168.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..702
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..702
                     /product="conserved oligomeric Golgi complex subunit 6
                     isoform X1"
                     /calculated_mol_wt=78238
     Region          68..701
                     /region_name="COG6"
                     /note="Conserved oligomeric complex COG6; smart01087"
                     /db_xref="CDD:215018"
     CDS             1..702
                     /gene="COG6"
                     /gene_synonym="CDG2L; COD2; SHNS"
                     /coded_by="XM_011535168.2:66..2174"
                     /db_xref="GeneID:57511"
                     /db_xref="HGNC:HGNC:18621"
                     /db_xref="MIM:606977"
ORIGIN      
        1 maegsgevva vsatgaangl nngaggtsat tcnplsrklh kiletrldnd kemlealkal
       61 stffvenslr trrnlrgdie rkslaineef vsifkevkee lesisedvqa msnccqdmts
      121 rlqaakeqtq dlivkttklq sesqkleira qvadaflskf qltsdemsll rgtregpite
      181 dffkalgrvk qihndvkvll rtnqqtagle imeqmallqe tayerlyrwa qsecrtltqe
      241 scdvspvltq amealqdrpv lykytldefg tarrstvvrg fidaltrggp ggtprpiemh
      301 shdplryvgd mlawlhqata sekehleall khvttqgvee niqevvghit egvcrplkvr
      361 ieqvivaepg avllykisnl lkfyhhtisg ivgnsatall ttieemhlls kkiffnslsl
      421 hasklmdkve lpppdlgpss alnqtlmllr evlashdssv vpldarqadf vqvlscvldp
      481 llqmctvsas nlgtadmatf mvnslymmkt tlalfeftdr rlemlqfqie ahldtlineq
      541 asyvltrvgl syiyntvqqh kpeqgslanm pnldsvtlka amvqfdryls apdnllipql
      601 nfllsatvkp sadwmepapl tvnllhsvfq ltcqspvetp sqthpeimly qltreqivkq
      661 stelvcrayg evyaavmnpi neykdpenil hrspqqvqtl ls
//
LOCUS       XP_016876167             575 aa            linear   PRI 05-AUG-2025
DEFINITION  kelch-like protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_016876167
VERSION     XP_016876167.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020678.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..575
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..575
                     /product="kelch-like protein 1 isoform X1"
                     /calculated_mol_wt=64243
     Region          33..555
                     /region_name="PHA03098"
                     /note="kelch-like protein; Provisional"
                     /db_xref="CDD:222983"
     Region          323..366
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          370..414
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          417..460
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          464..514
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          517..561
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     CDS             1..575
                     /gene="KLHL1"
                     /gene_synonym="MRP2"
                     /coded_by="XM_017020678.3:232..1959"
                     /db_xref="GeneID:57626"
                     /db_xref="HGNC:HGNC:6352"
                     /db_xref="MIM:605332"
ORIGIN      
        1 mtpqsdldss sseefyqavh haeqtfrkme sylkqqqlcd vilivgnrki pahrlvlssv
       61 sdyfaamfts dvceakqeei kmegidpnal wdlvqfaytg clelkedtie nllaaacllq
      121 lpqvvevcch flmkllhpsn clgirafada qgcielmkva hsytmenime virnqeflll
      181 paeelhklla sddvnvpdee tifhalmmwv kydmqsrcnd lsmllafirl pllppqilad
      241 lenhalfknd lecqklilea mkyhllperr tlmqsprtkp rkstvgtlya vggmdnnkga
      301 ttiekydlrt nlwiqagmmn grrlqfgvav iddklfvigg rdglktlntv ecynpktktw
      361 tvlppmsthr hglgvtvleg piyavgghdg wsylntverw dpqsqqwtfv asmsiarstv
      421 gvaalngkly svggrdgssc lssmeyydph tnkwnmcapm ckrrggvgva tcdgflyavg
      481 ghdapasnhc srlldyvery dpktdtwtmv aplsmprdav gvcllgdrly avggydgqty
      541 lntmesydpq tnewtqmasl nigragacvv vikqp
//
LOCUS       XP_016876168             525 aa            linear   PRI 05-AUG-2025
DEFINITION  kelch-like protein 1 isoform X2 [Homo sapiens].
ACCESSION   XP_016876168
VERSION     XP_016876168.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020679.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..525
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..525
                     /product="kelch-like protein 1 isoform X2"
                     /calculated_mol_wt=58499
     Region          4..505
                     /region_name="PHA03098"
                     /note="kelch-like protein; Provisional"
                     /db_xref="CDD:222983"
     Region          273..316
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          320..364
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          367..410
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          414..464
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          467..511
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     CDS             1..525
                     /gene="KLHL1"
                     /gene_synonym="MRP2"
                     /coded_by="XM_017020679.2:971..2548"
                     /db_xref="GeneID:57626"
                     /db_xref="HGNC:HGNC:6352"
                     /db_xref="MIM:605332"
ORIGIN      
        1 mnqrlvlssv sdyfaamfts dvceakqeei kmegidpnal wdlvqfaytg clelkedtie
       61 nllaaacllq lpqvvevcch flmkllhpsn clgirafada qgcielmkva hsytmenime
      121 virnqeflll paeelhklla sddvnvpdee tifhalmmwv kydmqsrcnd lsmllafirl
      181 pllppqilad lenhalfknd lecqklilea mkyhllperr tlmqsprtkp rkstvgtlya
      241 vggmdnnkga ttiekydlrt nlwiqagmmn grrlqfgvav iddklfvigg rdglktlntv
      301 ecynpktktw tvlppmsthr hglgvtvleg piyavgghdg wsylntverw dpqsqqwtfv
      361 asmsiarstv gvaalngkly svggrdgssc lssmeyydph tnkwnmcapm ckrrggvgva
      421 tcdgflyavg ghdapasnhc srlldyvery dpktdtwtmv aplsmprdav gvcllgdrly
      481 avggydgqty lntmesydpq tnewtqmasl nigragacvv vikqp
//
LOCUS       XP_011533474             343 aa            linear   PRI 05-AUG-2025
DEFINITION  replication factor C subunit 3 isoform X1 [Homo sapiens].
ACCESSION   XP_011533474
VERSION     XP_011533474.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535172.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..343
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..343
                     /product="replication factor C subunit 3 isoform X1"
                     /calculated_mol_wt=39091
     Region          3..>207
                     /region_name="rfc"
                     /note="replication factor C small subunit; Reviewed;
                     PRK00440"
                     /db_xref="CDD:234763"
     Region          187..252
                     /region_name="HLD_clamp"
                     /note="helical lid domain of clamp loader-like AAA+
                     proteins; cl38921"
                     /db_xref="CDD:365797"
     Site            order(223..224,227)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:350838"
     CDS             1..343
                     /gene="RFC3"
                     /gene_synonym="RFC38"
                     /coded_by="XM_011535172.4:31..1062"
                     /db_xref="GeneID:5983"
                     /db_xref="HGNC:HGNC:9971"
                     /db_xref="MIM:600405"
ORIGIN      
        1 mslwvdkyrp cslgrldyhk eqaaqlrnlv qcgdfphllv ygpsgagkkt rimcilrely
       61 gvgveklrie hqtittpskk kieistiasn yhlevnpsda gnsdrvviqe mlktvaqsqq
      121 letnsqrdfk vvlltevdkl tkdaqhalrr tmekymstcr lilccnstsk vippirsrcl
      181 avrvpapsie dichvlstvc kkeglnlpsq lahrlaeksc rnlrkallmc eacrvqqypf
      241 tadqeipetd wevylretan aivsqqtpqr llevrgrlye llthcippei imkmrnwiql
      301 imgatlinsq lptkkwavnt aqrtyvsmik spqclfqnli wsk
//
LOCUS       XP_016876169             313 aa            linear   PRI 05-AUG-2025
DEFINITION  replication factor C subunit 3 isoform X2 [Homo sapiens].
ACCESSION   XP_016876169
VERSION     XP_016876169.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020680.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..313
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..313
                     /product="replication factor C subunit 3 isoform X2"
                     /calculated_mol_wt=35508
     Region          3..>207
                     /region_name="rfc"
                     /note="replication factor C small subunit; Reviewed;
                     PRK00440"
                     /db_xref="CDD:234763"
     Region          187..252
                     /region_name="HLD_clamp"
                     /note="helical lid domain of clamp loader-like AAA+
                     proteins; cl38921"
                     /db_xref="CDD:365797"
     Site            order(223..224,227)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:350838"
     CDS             1..313
                     /gene="RFC3"
                     /gene_synonym="RFC38"
                     /coded_by="XM_017020680.3:31..972"
                     /db_xref="GeneID:5983"
                     /db_xref="HGNC:HGNC:9971"
                     /db_xref="MIM:600405"
ORIGIN      
        1 mslwvdkyrp cslgrldyhk eqaaqlrnlv qcgdfphllv ygpsgagkkt rimcilrely
       61 gvgveklrie hqtittpskk kieistiasn yhlevnpsda gnsdrvviqe mlktvaqsqq
      121 letnsqrdfk vvlltevdkl tkdaqhalrr tmekymstcr lilccnstsk vippirsrcl
      181 avrvpapsie dichvlstvc kkeglnlpsq lahrlaeksc rnlrkallmc eacrvqqypf
      241 tadqeipetd wevylretan aivsqqtpqr llevrgrlye llthcippei imklkdetgl
      301 smitqsfidp thh
//
LOCUS       XP_047286445             313 aa            linear   PRI 05-AUG-2025
DEFINITION  replication factor C subunit 3 isoform X2 [Homo sapiens].
ACCESSION   XP_047286445
VERSION     XP_047286445.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430489.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..313
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..313
                     /product="replication factor C subunit 3 isoform X2"
                     /calculated_mol_wt=35508
     Region          3..>207
                     /region_name="rfc"
                     /note="replication factor C small subunit; Reviewed;
                     PRK00440"
                     /db_xref="CDD:234763"
     Region          187..252
                     /region_name="HLD_clamp"
                     /note="helical lid domain of clamp loader-like AAA+
                     proteins; cl38921"
                     /db_xref="CDD:365797"
     Site            order(223..224,227)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:350838"
     CDS             1..313
                     /gene="RFC3"
                     /gene_synonym="RFC38"
                     /coded_by="XM_047430489.1:31..972"
                     /db_xref="GeneID:5983"
                     /db_xref="HGNC:HGNC:9971"
                     /db_xref="MIM:600405"
ORIGIN      
        1 mslwvdkyrp cslgrldyhk eqaaqlrnlv qcgdfphllv ygpsgagkkt rimcilrely
       61 gvgveklrie hqtittpskk kieistiasn yhlevnpsda gnsdrvviqe mlktvaqsqq
      121 letnsqrdfk vvlltevdkl tkdaqhalrr tmekymstcr lilccnstsk vippirsrcl
      181 avrvpapsie dichvlstvc kkeglnlpsq lahrlaeksc rnlrkallmc eacrvqqypf
      241 tadqeipetd wevylretan aivsqqtpqr llevrgrlye llthcippei imklkdetgl
      301 smitqsfidp thh
//
LOCUS       XP_047286446             313 aa            linear   PRI 05-AUG-2025
DEFINITION  replication factor C subunit 3 isoform X2 [Homo sapiens].
ACCESSION   XP_047286446
VERSION     XP_047286446.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430490.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..313
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..313
                     /product="replication factor C subunit 3 isoform X2"
                     /calculated_mol_wt=35508
     Region          3..>207
                     /region_name="rfc"
                     /note="replication factor C small subunit; Reviewed;
                     PRK00440"
                     /db_xref="CDD:234763"
     Region          187..252
                     /region_name="HLD_clamp"
                     /note="helical lid domain of clamp loader-like AAA+
                     proteins; cl38921"
                     /db_xref="CDD:365797"
     Site            order(223..224,227)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:350838"
     CDS             1..313
                     /gene="RFC3"
                     /gene_synonym="RFC38"
                     /coded_by="XM_047430490.1:31..972"
                     /db_xref="GeneID:5983"
                     /db_xref="HGNC:HGNC:9971"
                     /db_xref="MIM:600405"
ORIGIN      
        1 mslwvdkyrp cslgrldyhk eqaaqlrnlv qcgdfphllv ygpsgagkkt rimcilrely
       61 gvgveklrie hqtittpskk kieistiasn yhlevnpsda gnsdrvviqe mlktvaqsqq
      121 letnsqrdfk vvlltevdkl tkdaqhalrr tmekymstcr lilccnstsk vippirsrcl
      181 avrvpapsie dichvlstvc kkeglnlpsq lahrlaeksc rnlrkallmc eacrvqqypf
      241 tadqeipetd wevylretan aivsqqtpqr llevrgrlye llthcippei imklkdetgl
      301 smitqsfidp thh
//
LOCUS       XP_047286447             313 aa            linear   PRI 05-AUG-2025
DEFINITION  replication factor C subunit 3 isoform X2 [Homo sapiens].
ACCESSION   XP_047286447
VERSION     XP_047286447.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430491.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 4% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..313
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..313
                     /product="replication factor C subunit 3 isoform X2"
                     /calculated_mol_wt=35508
     Region          3..>207
                     /region_name="rfc"
                     /note="replication factor C small subunit; Reviewed;
                     PRK00440"
                     /db_xref="CDD:234763"
     Region          187..252
                     /region_name="HLD_clamp"
                     /note="helical lid domain of clamp loader-like AAA+
                     proteins; cl38921"
                     /db_xref="CDD:365797"
     Site            order(223..224,227)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:350838"
     CDS             1..313
                     /gene="RFC3"
                     /gene_synonym="RFC38"
                     /coded_by="XM_047430491.1:31..972"
                     /db_xref="GeneID:5983"
                     /db_xref="HGNC:HGNC:9971"
                     /db_xref="MIM:600405"
ORIGIN      
        1 mslwvdkyrp cslgrldyhk eqaaqlrnlv qcgdfphllv ygpsgagkkt rimcilrely
       61 gvgveklrie hqtittpskk kieistiasn yhlevnpsda gnsdrvviqe mlktvaqsqq
      121 letnsqrdfk vvlltevdkl tkdaqhalrr tmekymstcr lilccnstsk vippirsrcl
      181 avrvpapsie dichvlstvc kkeglnlpsq lahrlaeksc rnlrkallmc eacrvqqypf
      241 tadqeipetd wevylretan aivsqqtpqr llevrgrlye llthcippei imklkdetgl
      301 smitqsfidp thh
//
LOCUS       XP_011533475             298 aa            linear   PRI 05-AUG-2025
DEFINITION  replication factor C subunit 3 isoform X3 [Homo sapiens].
ACCESSION   XP_011533475
VERSION     XP_011533475.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535173.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..298
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..298
                     /product="replication factor C subunit 3 isoform X3"
                     /calculated_mol_wt=33913
     Region          3..282
                     /region_name="PRK12402"
                     /note="replication factor C small subunit 2; Reviewed"
                     /db_xref="CDD:237090"
     CDS             1..298
                     /gene="RFC3"
                     /gene_synonym="RFC38"
                     /coded_by="XM_011535173.4:31..927"
                     /db_xref="GeneID:5983"
                     /db_xref="HGNC:HGNC:9971"
                     /db_xref="MIM:600405"
ORIGIN      
        1 mslwvdkyrp cslgrldyhk eqaaqlrnlv qcgdfphllv ygpsgagkkt rimcilrely
       61 gvgveklrie hqtittpskk kieistiasn yhlevnpsda gnsdrvviqe mlktvaqsqq
      121 letnsqrdfk vvlltevdkl tkdaqhalrr tmekymstcr lilccnstsk vippirsrcl
      181 avrvpapsie dichvlstvc kkeglnlpsq lahrlaeksc rnlrkallmc eacrvqqypf
      241 tadqeipetd wevylretan aivsqqtpqr llevrgrlye llthcippei imklmkrk
//
LOCUS       XP_011533477             297 aa            linear   PRI 05-AUG-2025
DEFINITION  replication factor C subunit 3 isoform X4 [Homo sapiens].
ACCESSION   XP_011533477
VERSION     XP_011533477.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535175.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..297
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..297
                     /product="replication factor C subunit 3 isoform X4"
                     /calculated_mol_wt=33641
     Region          3..282
                     /region_name="PRK12402"
                     /note="replication factor C small subunit 2; Reviewed"
                     /db_xref="CDD:237090"
     CDS             1..297
                     /gene="RFC3"
                     /gene_synonym="RFC38"
                     /coded_by="XM_011535175.3:31..924"
                     /db_xref="GeneID:5983"
                     /db_xref="HGNC:HGNC:9971"
                     /db_xref="MIM:600405"
ORIGIN      
        1 mslwvdkyrp cslgrldyhk eqaaqlrnlv qcgdfphllv ygpsgagkkt rimcilrely
       61 gvgveklrie hqtittpskk kieistiasn yhlevnpsda gnsdrvviqe mlktvaqsqq
      121 letnsqrdfk vvlltevdkl tkdaqhalrr tmekymstcr lilccnstsk vippirsrcl
      181 avrvpapsie dichvlstvc kkeglnlpsq lahrlaeksc rnlrkallmc eacrvqqypf
      241 tadqeipetd wevylretan aivsqqtpqr llevrgrlye llthcippei imkavsq
//
LOCUS       XP_016876170             297 aa            linear   PRI 05-AUG-2025
DEFINITION  replication factor C subunit 3 isoform X5 [Homo sapiens].
ACCESSION   XP_016876170
VERSION     XP_016876170.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020681.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..297
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..297
                     /product="replication factor C subunit 3 isoform X5"
                     /calculated_mol_wt=33768
     Region          3..>207
                     /region_name="rfc"
                     /note="replication factor C small subunit; Reviewed;
                     PRK00440"
                     /db_xref="CDD:234763"
     Region          187..252
                     /region_name="HLD_clamp"
                     /note="helical lid domain of clamp loader-like AAA+
                     proteins; cl38921"
                     /db_xref="CDD:365797"
     Site            order(223..224,227)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:350838"
     CDS             1..297
                     /gene="RFC3"
                     /gene_synonym="RFC38"
                     /coded_by="XM_017020681.3:31..924"
                     /db_xref="GeneID:5983"
                     /db_xref="HGNC:HGNC:9971"
                     /db_xref="MIM:600405"
ORIGIN      
        1 mslwvdkyrp cslgrldyhk eqaaqlrnlv qcgdfphllv ygpsgagkkt rimcilrely
       61 gvgveklrie hqtittpskk kieistiasn yhlevnpsda gnsdrvviqe mlktvaqsqq
      121 letnsqrdfk vvlltevdkl tkdaqhalrr tmekymstcr lilccnstsk vippirsrcl
      181 avrvpapsie dichvlstvc kkeglnlpsq lahrlaeksc rnlrkallmc eacrvqqypf
      241 tadqeipetd wevylretan aivsqqtpqr llevrgrlye llthcippei imkvwll
//
LOCUS       XP_016876171             293 aa            linear   PRI 05-AUG-2025
DEFINITION  replication factor C subunit 3 isoform X6 [Homo sapiens].
ACCESSION   XP_016876171
VERSION     XP_016876171.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020682.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..293
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..293
                     /product="replication factor C subunit 3 isoform X6"
                     /calculated_mol_wt=33256
     Region          3..282
                     /region_name="PRK12402"
                     /note="replication factor C small subunit 2; Reviewed"
                     /db_xref="CDD:237090"
     CDS             1..293
                     /gene="RFC3"
                     /gene_synonym="RFC38"
                     /coded_by="XM_017020682.3:31..912"
                     /db_xref="GeneID:5983"
                     /db_xref="HGNC:HGNC:9971"
                     /db_xref="MIM:600405"
ORIGIN      
        1 mslwvdkyrp cslgrldyhk eqaaqlrnlv qcgdfphllv ygpsgagkkt rimcilrely
       61 gvgveklrie hqtittpskk kieistiasn yhlevnpsda gnsdrvviqe mlktvaqsqq
      121 letnsqrdfk vvlltevdkl tkdaqhalrr tmekymstcr lilccnstsk vippirsrcl
      181 avrvpapsie dichvlstvc kkeglnlpsq lahrlaeksc rnlrkallmc eacrvqqypf
      241 tadqeipetd wevylretan aivsqqtpqr llevrgrlye llthcippei imk
//
LOCUS       XP_047286448             293 aa            linear   PRI 05-AUG-2025
DEFINITION  replication factor C subunit 3 isoform X6 [Homo sapiens].
ACCESSION   XP_047286448
VERSION     XP_047286448.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430492.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 44% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..293
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..293
                     /product="replication factor C subunit 3 isoform X6"
                     /calculated_mol_wt=33256
     Region          3..282
                     /region_name="PRK12402"
                     /note="replication factor C small subunit 2; Reviewed"
                     /db_xref="CDD:237090"
     CDS             1..293
                     /gene="RFC3"
                     /gene_synonym="RFC38"
                     /coded_by="XM_047430492.1:31..912"
                     /db_xref="GeneID:5983"
                     /db_xref="HGNC:HGNC:9971"
                     /db_xref="MIM:600405"
ORIGIN      
        1 mslwvdkyrp cslgrldyhk eqaaqlrnlv qcgdfphllv ygpsgagkkt rimcilrely
       61 gvgveklrie hqtittpskk kieistiasn yhlevnpsda gnsdrvviqe mlktvaqsqq
      121 letnsqrdfk vvlltevdkl tkdaqhalrr tmekymstcr lilccnstsk vippirsrcl
      181 avrvpapsie dichvlstvc kkeglnlpsq lahrlaeksc rnlrkallmc eacrvqqypf
      241 tadqeipetd wevylretan aivsqqtpqr llevrgrlye llthcippei imk
//
LOCUS       XP_016876172             291 aa            linear   PRI 05-AUG-2025
DEFINITION  replication factor C subunit 3 isoform X7 [Homo sapiens].
ACCESSION   XP_016876172
VERSION     XP_016876172.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020683.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..291
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..291
                     /product="replication factor C subunit 3 isoform X7"
                     /calculated_mol_wt=33088
     Region          3..>207
                     /region_name="rfc"
                     /note="replication factor C small subunit; Reviewed;
                     PRK00440"
                     /db_xref="CDD:234763"
     Region          187..252
                     /region_name="HLD_clamp"
                     /note="helical lid domain of clamp loader-like AAA+
                     proteins; cl38921"
                     /db_xref="CDD:365797"
     Site            order(223..224,227)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:350838"
     CDS             1..291
                     /gene="RFC3"
                     /gene_synonym="RFC38"
                     /coded_by="XM_017020683.3:31..906"
                     /db_xref="GeneID:5983"
                     /db_xref="HGNC:HGNC:9971"
                     /db_xref="MIM:600405"
ORIGIN      
        1 mslwvdkyrp cslgrldyhk eqaaqlrnlv qcgdfphllv ygpsgagkkt rimcilrely
       61 gvgveklrie hqtittpskk kieistiasn yhlevnpsda gnsdrvviqe mlktvaqsqq
      121 letnsqrdfk vvlltevdkl tkdaqhalrr tmekymstcr lilccnstsk vippirsrcl
      181 avrvpapsie dichvlstvc kkeglnlpsq lahrlaeksc rnlrkallmc eacrvqqypf
      241 tadqeipetd wevylretan aivsqqtpqr hvrrnqeavt ysedlqrttc y
//
LOCUS       XP_047286449             328 aa            linear   PRI 05-AUG-2025
DEFINITION  rhodopsin kinase GRK1 isoform X1 [Homo sapiens].
ACCESSION   XP_047286449
VERSION     XP_047286449.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430493.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..328
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..328
                     /product="rhodopsin kinase GRK1 isoform X1"
                     /calculated_mol_wt=36896
     Region          1..240
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..328
                     /gene="GRK1"
                     /gene_synonym="GPRK1; RHOK; RK"
                     /coded_by="XM_047430493.1:53..1039"
                     /db_xref="GeneID:6011"
                     /db_xref="HGNC:HGNC:10013"
                     /db_xref="MIM:180381"
ORIGIN      
        1 mvekkilmkv hsrfivslay afetkadlcl vmtimnggdi ryhiynvnee npgfpepral
       61 fytaqiicgl ehlhqrrivy rdlkpenvll dndgnvrisd lglavelldg qsktkgyagt
      121 pgfmapellq geeydfsvdy falgvtlyem iaargpfrar gekvenkelk hriisepvky
      181 pdkfsqaskd fceallekdp ekrlgfrdet cdklrahplf kdlnwrqlea gmlmppfipd
      241 sktvyakdiq dvgafstvkg vafdktdtef fqefatgncp ipwqeemiet gifgelnvwr
      301 sdgqmpddmk gisggsssss ksgmclvs
//
LOCUS       XP_005266542             685 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase RNF6 isoform X1 [Homo sapiens].
ACCESSION   XP_005266542
VERSION     XP_005266542.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266485.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..685
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..685
                     /product="E3 ubiquitin-protein ligase RNF6 isoform X1"
                     /calculated_mol_wt=77960
     Region          630..681
                     /region_name="RING-H2_RNF6"
                     /note="RING finger, H2 subclass, found in E3
                     ubiquitin-protein ligase RNF6 and similar proteins;
                     cd16673"
                     /db_xref="CDD:438335"
     CDS             1..685
                     /gene="RNF6"
                     /coded_by="XM_005266485.4:582..2639"
                     /db_xref="GeneID:6049"
                     /db_xref="HGNC:HGNC:10069"
                     /db_xref="MIM:604242"
ORIGIN      
        1 mnqsrsrsdg gseetlpqdh nhhenerrwq qerlhreeay yqfinelnde dyrlmrdhnl
       61 lgtpgeitse elqqrldgvk eqlasqpdlr dgtnyrdsev presshedsl lewlntfrrt
      121 gnatrsgqng nqtwravsrt npnngefrfs leihvnhenr gfeihgedyt diplsdsnrd
      181 htanrqqrst spvarrtrsq tsvnfngsss niprtrlasr gqnpaegsfs tlgrlrngig
      241 gaagiprana srtnfsshtn qsggselrqr egqrfgaahv wengarsnvt vrntnqrlep
      301 irlrstsnsr srspiqrqsg tvyhnsqres rpvqqttrrs vrrrgrtrvf leqdrererr
      361 gtaytpfsns rlvsritvee geessrssta vrrhptitld lqvrrirpge nrdrdsianr
      421 trsrvglaen tvtiesnsgg frrtisrler sgirtyvsti tvplrrisen elvepssval
      481 rsilrqimtg fgelsslmea dseselqrng qhlpdmhsel snlgtdnnrs qhregssqdr
      541 qaqgdstemh genettqpht rnsdsrggrq lrnpnnlvet gtlpilrlah ffllnesddd
      601 drirgltkeq idnlstrhye hnsidselgk icsvcisdyv tgnklrqlpc mhefhihcid
      661 rwlsenctcp icrqpvlgsn ianng
//
LOCUS       XP_011533479             685 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase RNF6 isoform X1 [Homo sapiens].
ACCESSION   XP_011533479
VERSION     XP_011533479.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535177.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..685
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..685
                     /product="E3 ubiquitin-protein ligase RNF6 isoform X1"
                     /calculated_mol_wt=77960
     Region          630..681
                     /region_name="RING-H2_RNF6"
                     /note="RING finger, H2 subclass, found in E3
                     ubiquitin-protein ligase RNF6 and similar proteins;
                     cd16673"
                     /db_xref="CDD:438335"
     CDS             1..685
                     /gene="RNF6"
                     /coded_by="XM_011535177.4:594..2651"
                     /db_xref="GeneID:6049"
                     /db_xref="HGNC:HGNC:10069"
                     /db_xref="MIM:604242"
ORIGIN      
        1 mnqsrsrsdg gseetlpqdh nhhenerrwq qerlhreeay yqfinelnde dyrlmrdhnl
       61 lgtpgeitse elqqrldgvk eqlasqpdlr dgtnyrdsev presshedsl lewlntfrrt
      121 gnatrsgqng nqtwravsrt npnngefrfs leihvnhenr gfeihgedyt diplsdsnrd
      181 htanrqqrst spvarrtrsq tsvnfngsss niprtrlasr gqnpaegsfs tlgrlrngig
      241 gaagiprana srtnfsshtn qsggselrqr egqrfgaahv wengarsnvt vrntnqrlep
      301 irlrstsnsr srspiqrqsg tvyhnsqres rpvqqttrrs vrrrgrtrvf leqdrererr
      361 gtaytpfsns rlvsritvee geessrssta vrrhptitld lqvrrirpge nrdrdsianr
      421 trsrvglaen tvtiesnsgg frrtisrler sgirtyvsti tvplrrisen elvepssval
      481 rsilrqimtg fgelsslmea dseselqrng qhlpdmhsel snlgtdnnrs qhregssqdr
      541 qaqgdstemh genettqpht rnsdsrggrq lrnpnnlvet gtlpilrlah ffllnesddd
      601 drirgltkeq idnlstrhye hnsidselgk icsvcisdyv tgnklrqlpc mhefhihcid
      661 rwlsenctcp icrqpvlgsn ianng
//
LOCUS       XP_005266543             685 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase RNF6 isoform X1 [Homo sapiens].
ACCESSION   XP_005266543
VERSION     XP_005266543.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266486.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..685
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..685
                     /product="E3 ubiquitin-protein ligase RNF6 isoform X1"
                     /calculated_mol_wt=77960
     Region          630..681
                     /region_name="RING-H2_RNF6"
                     /note="RING finger, H2 subclass, found in E3
                     ubiquitin-protein ligase RNF6 and similar proteins;
                     cd16673"
                     /db_xref="CDD:438335"
     CDS             1..685
                     /gene="RNF6"
                     /coded_by="XM_005266486.3:300..2357"
                     /db_xref="GeneID:6049"
                     /db_xref="HGNC:HGNC:10069"
                     /db_xref="MIM:604242"
ORIGIN      
        1 mnqsrsrsdg gseetlpqdh nhhenerrwq qerlhreeay yqfinelnde dyrlmrdhnl
       61 lgtpgeitse elqqrldgvk eqlasqpdlr dgtnyrdsev presshedsl lewlntfrrt
      121 gnatrsgqng nqtwravsrt npnngefrfs leihvnhenr gfeihgedyt diplsdsnrd
      181 htanrqqrst spvarrtrsq tsvnfngsss niprtrlasr gqnpaegsfs tlgrlrngig
      241 gaagiprana srtnfsshtn qsggselrqr egqrfgaahv wengarsnvt vrntnqrlep
      301 irlrstsnsr srspiqrqsg tvyhnsqres rpvqqttrrs vrrrgrtrvf leqdrererr
      361 gtaytpfsns rlvsritvee geessrssta vrrhptitld lqvrrirpge nrdrdsianr
      421 trsrvglaen tvtiesnsgg frrtisrler sgirtyvsti tvplrrisen elvepssval
      481 rsilrqimtg fgelsslmea dseselqrng qhlpdmhsel snlgtdnnrs qhregssqdr
      541 qaqgdstemh genettqpht rnsdsrggrq lrnpnnlvet gtlpilrlah ffllnesddd
      601 drirgltkeq idnlstrhye hnsidselgk icsvcisdyv tgnklrqlpc mhefhihcid
      661 rwlsenctcp icrqpvlgsn ianng
//
LOCUS       XP_024305158             685 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase RNF6 isoform X1 [Homo sapiens].
ACCESSION   XP_024305158
VERSION     XP_024305158.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449390.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..685
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..685
                     /product="E3 ubiquitin-protein ligase RNF6 isoform X1"
                     /calculated_mol_wt=77960
     Region          630..681
                     /region_name="RING-H2_RNF6"
                     /note="RING finger, H2 subclass, found in E3
                     ubiquitin-protein ligase RNF6 and similar proteins;
                     cd16673"
                     /db_xref="CDD:438335"
     CDS             1..685
                     /gene="RNF6"
                     /coded_by="XM_024449390.2:157..2214"
                     /db_xref="GeneID:6049"
                     /db_xref="HGNC:HGNC:10069"
                     /db_xref="MIM:604242"
ORIGIN      
        1 mnqsrsrsdg gseetlpqdh nhhenerrwq qerlhreeay yqfinelnde dyrlmrdhnl
       61 lgtpgeitse elqqrldgvk eqlasqpdlr dgtnyrdsev presshedsl lewlntfrrt
      121 gnatrsgqng nqtwravsrt npnngefrfs leihvnhenr gfeihgedyt diplsdsnrd
      181 htanrqqrst spvarrtrsq tsvnfngsss niprtrlasr gqnpaegsfs tlgrlrngig
      241 gaagiprana srtnfsshtn qsggselrqr egqrfgaahv wengarsnvt vrntnqrlep
      301 irlrstsnsr srspiqrqsg tvyhnsqres rpvqqttrrs vrrrgrtrvf leqdrererr
      361 gtaytpfsns rlvsritvee geessrssta vrrhptitld lqvrrirpge nrdrdsianr
      421 trsrvglaen tvtiesnsgg frrtisrler sgirtyvsti tvplrrisen elvepssval
      481 rsilrqimtg fgelsslmea dseselqrng qhlpdmhsel snlgtdnnrs qhregssqdr
      541 qaqgdstemh genettqpht rnsdsrggrq lrnpnnlvet gtlpilrlah ffllnesddd
      601 drirgltkeq idnlstrhye hnsidselgk icsvcisdyv tgnklrqlpc mhefhihcid
      661 rwlsenctcp icrqpvlgsn ianng
//
LOCUS       XP_047286450             329 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase RNF6 isoform X2 [Homo sapiens].
ACCESSION   XP_047286450
VERSION     XP_047286450.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430494.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..329
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..329
                     /product="E3 ubiquitin-protein ligase RNF6 isoform X2"
                     /calculated_mol_wt=36963
     Region          274..325
                     /region_name="RING-H2_RNF6"
                     /note="RING finger, H2 subclass, found in E3
                     ubiquitin-protein ligase RNF6 and similar proteins;
                     cd16673"
                     /db_xref="CDD:438335"
     CDS             1..329
                     /gene="RNF6"
                     /coded_by="XM_047430494.1:172..1161"
                     /db_xref="GeneID:6049"
                     /db_xref="HGNC:HGNC:10069"
                     /db_xref="MIM:604242"
ORIGIN      
        1 mqlevdkmgt klgellvsri tveegeessr sstavrrhpt itldlqvrri rpgenrdrds
       61 ianrtrsrvg laentvties nsggfrrtis rlersgirty vstitvplrr isenelveps
      121 svalrsilrq imtgfgelss lmeadsesel qrngqhlpdm hselsnlgtd nnrsqhregs
      181 sqdrqaqgds temhgenett qphtrnsdsr ggrqlrnpnn lvetgtlpil rlahffllne
      241 sddddrirgl tkeqidnlst rhyehnsids elgkicsvci sdyvtgnklr qlpcmhefhi
      301 hcidrwlsen ctcpicrqpv lgsnianng
//
LOCUS       XP_016876174             176 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase RNF6 isoform X3 [Homo sapiens].
ACCESSION   XP_016876174
VERSION     XP_016876174.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020685.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..176
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..176
                     /product="E3 ubiquitin-protein ligase RNF6 isoform X3"
                     /calculated_mol_wt=20590
     CDS             1..176
                     /gene="RNF6"
                     /coded_by="XM_017020685.3:635..1165"
                     /db_xref="GeneID:6049"
                     /db_xref="HGNC:HGNC:10069"
                     /db_xref="MIM:604242"
ORIGIN      
        1 mnqsrsrsdg gseetlpqdh nhhenerrwq qerlhreeay yqfinelnde dyrlmrdhnl
       61 lgtpgeitse elqqrldgvk eqlasqpdlr dgtnyrdsev presshedsl lewlntfrrt
      121 gnatrsgqng nqtwraacvk nnsrrrrriq qilnccttts nnhtgpssek dpswrk
//
LOCUS       XP_016876175             176 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase RNF6 isoform X3 [Homo sapiens].
ACCESSION   XP_016876175
VERSION     XP_016876175.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020686.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..176
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..176
                     /product="E3 ubiquitin-protein ligase RNF6 isoform X3"
                     /calculated_mol_wt=20590
     CDS             1..176
                     /gene="RNF6"
                     /coded_by="XM_017020686.2:471..1001"
                     /db_xref="GeneID:6049"
                     /db_xref="HGNC:HGNC:10069"
                     /db_xref="MIM:604242"
ORIGIN      
        1 mnqsrsrsdg gseetlpqdh nhhenerrwq qerlhreeay yqfinelnde dyrlmrdhnl
       61 lgtpgeitse elqqrldgvk eqlasqpdlr dgtnyrdsev presshedsl lewlntfrrt
      121 gnatrsgqng nqtwraacvk nnsrrrrriq qilnccttts nnhtgpssek dpswrk
//
LOCUS       XP_047286451             176 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase RNF6 isoform X3 [Homo sapiens].
ACCESSION   XP_047286451
VERSION     XP_047286451.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430495.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..176
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..176
                     /product="E3 ubiquitin-protein ligase RNF6 isoform X3"
                     /calculated_mol_wt=20590
     CDS             1..176
                     /gene="RNF6"
                     /coded_by="XM_047430495.1:582..1112"
                     /db_xref="GeneID:6049"
                     /db_xref="HGNC:HGNC:10069"
                     /db_xref="MIM:604242"
ORIGIN      
        1 mnqsrsrsdg gseetlpqdh nhhenerrwq qerlhreeay yqfinelnde dyrlmrdhnl
       61 lgtpgeitse elqqrldgvk eqlasqpdlr dgtnyrdsev presshedsl lewlntfrrt
      121 gnatrsgqng nqtwraacvk nnsrrrrriq qilnccttts nnhtgpssek dpswrk
//
LOCUS       XP_024305159             176 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase RNF6 isoform X3 [Homo sapiens].
ACCESSION   XP_024305159
VERSION     XP_024305159.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449391.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..176
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..176
                     /product="E3 ubiquitin-protein ligase RNF6 isoform X3"
                     /calculated_mol_wt=20590
     CDS             1..176
                     /gene="RNF6"
                     /coded_by="XM_024449391.2:431..961"
                     /db_xref="GeneID:6049"
                     /db_xref="HGNC:HGNC:10069"
                     /db_xref="MIM:604242"
ORIGIN      
        1 mnqsrsrsdg gseetlpqdh nhhenerrwq qerlhreeay yqfinelnde dyrlmrdhnl
       61 lgtpgeitse elqqrldgvk eqlasqpdlr dgtnyrdsev presshedsl lewlntfrrt
      121 gnatrsgqng nqtwraacvk nnsrrrrriq qilnccttts nnhtgpssek dpswrk
//
LOCUS       XP_047286452             176 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase RNF6 isoform X3 [Homo sapiens].
ACCESSION   XP_047286452
VERSION     XP_047286452.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430496.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..176
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..176
                     /product="E3 ubiquitin-protein ligase RNF6 isoform X3"
                     /calculated_mol_wt=20590
     CDS             1..176
                     /gene="RNF6"
                     /coded_by="XM_047430496.1:594..1124"
                     /db_xref="GeneID:6049"
                     /db_xref="HGNC:HGNC:10069"
                     /db_xref="MIM:604242"
ORIGIN      
        1 mnqsrsrsdg gseetlpqdh nhhenerrwq qerlhreeay yqfinelnde dyrlmrdhnl
       61 lgtpgeitse elqqrldgvk eqlasqpdlr dgtnyrdsev presshedsl lewlntfrrt
      121 gnatrsgqng nqtwraacvk nnsrrrrriq qilnccttts nnhtgpssek dpswrk
//
LOCUS       XP_016876176             176 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase RNF6 isoform X3 [Homo sapiens].
ACCESSION   XP_016876176
VERSION     XP_016876176.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020687.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..176
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..176
                     /product="E3 ubiquitin-protein ligase RNF6 isoform X3"
                     /calculated_mol_wt=20590
     CDS             1..176
                     /gene="RNF6"
                     /coded_by="XM_017020687.2:300..830"
                     /db_xref="GeneID:6049"
                     /db_xref="HGNC:HGNC:10069"
                     /db_xref="MIM:604242"
ORIGIN      
        1 mnqsrsrsdg gseetlpqdh nhhenerrwq qerlhreeay yqfinelnde dyrlmrdhnl
       61 lgtpgeitse elqqrldgvk eqlasqpdlr dgtnyrdsev presshedsl lewlntfrrt
      121 gnatrsgqng nqtwraacvk nnsrrrrriq qilnccttts nnhtgpssek dpswrk
//
LOCUS       XP_024305160             176 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase RNF6 isoform X3 [Homo sapiens].
ACCESSION   XP_024305160
VERSION     XP_024305160.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449392.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..176
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..176
                     /product="E3 ubiquitin-protein ligase RNF6 isoform X3"
                     /calculated_mol_wt=20590
     CDS             1..176
                     /gene="RNF6"
                     /coded_by="XM_024449392.2:173..703"
                     /db_xref="GeneID:6049"
                     /db_xref="HGNC:HGNC:10069"
                     /db_xref="MIM:604242"
ORIGIN      
        1 mnqsrsrsdg gseetlpqdh nhhenerrwq qerlhreeay yqfinelnde dyrlmrdhnl
       61 lgtpgeitse elqqrldgvk eqlasqpdlr dgtnyrdsev presshedsl lewlntfrrt
      121 gnatrsgqng nqtwraacvk nnsrrrrriq qilnccttts nnhtgpssek dpswrk
//
LOCUS       XP_011533480             142 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase RNF6 isoform X4 [Homo sapiens].
ACCESSION   XP_011533480
VERSION     XP_011533480.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535178.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..142
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..142
                     /product="E3 ubiquitin-protein ligase RNF6 isoform X4"
                     /calculated_mol_wt=16549
     CDS             1..142
                     /gene="RNF6"
                     /coded_by="XM_011535178.3:635..1063"
                     /db_xref="GeneID:6049"
                     /db_xref="HGNC:HGNC:10069"
                     /db_xref="MIM:604242"
ORIGIN      
        1 mnqsrsrsdg gseetlpqdh nhhenerrwq qerlhreeay yqfinelnde dyrlmrdhnl
       61 lgtpgeitse elqqrldgvk eqlasqpdlr dgtnyrdsev presshedsl lewlntfrrt
      121 gnatrsgqng nqtwraalpd ts
//
LOCUS       XP_047286454             142 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase RNF6 isoform X4 [Homo sapiens].
ACCESSION   XP_047286454
VERSION     XP_047286454.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430498.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..142
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..142
                     /product="E3 ubiquitin-protein ligase RNF6 isoform X4"
                     /calculated_mol_wt=16549
     CDS             1..142
                     /gene="RNF6"
                     /coded_by="XM_047430498.1:582..1010"
                     /db_xref="GeneID:6049"
                     /db_xref="HGNC:HGNC:10069"
                     /db_xref="MIM:604242"
ORIGIN      
        1 mnqsrsrsdg gseetlpqdh nhhenerrwq qerlhreeay yqfinelnde dyrlmrdhnl
       61 lgtpgeitse elqqrldgvk eqlasqpdlr dgtnyrdsev presshedsl lewlntfrrt
      121 gnatrsgqng nqtwraalpd ts
//
LOCUS       XP_047286455             142 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase RNF6 isoform X4 [Homo sapiens].
ACCESSION   XP_047286455
VERSION     XP_047286455.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430499.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..142
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..142
                     /product="E3 ubiquitin-protein ligase RNF6 isoform X4"
                     /calculated_mol_wt=16549
     CDS             1..142
                     /gene="RNF6"
                     /coded_by="XM_047430499.1:594..1022"
                     /db_xref="GeneID:6049"
                     /db_xref="HGNC:HGNC:10069"
                     /db_xref="MIM:604242"
ORIGIN      
        1 mnqsrsrsdg gseetlpqdh nhhenerrwq qerlhreeay yqfinelnde dyrlmrdhnl
       61 lgtpgeitse elqqrldgvk eqlasqpdlr dgtnyrdsev presshedsl lewlntfrrt
      121 gnatrsgqng nqtwraalpd ts
//
LOCUS       XP_047286456             142 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase RNF6 isoform X4 [Homo sapiens].
ACCESSION   XP_047286456
VERSION     XP_047286456.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430500.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..142
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..142
                     /product="E3 ubiquitin-protein ligase RNF6 isoform X4"
                     /calculated_mol_wt=16549
     CDS             1..142
                     /gene="RNF6"
                     /coded_by="XM_047430500.1:157..585"
                     /db_xref="GeneID:6049"
                     /db_xref="HGNC:HGNC:10069"
                     /db_xref="MIM:604242"
ORIGIN      
        1 mnqsrsrsdg gseetlpqdh nhhenerrwq qerlhreeay yqfinelnde dyrlmrdhnl
       61 lgtpgeitse elqqrldgvk eqlasqpdlr dgtnyrdsev presshedsl lewlntfrrt
      121 gnatrsgqng nqtwraalpd ts
//
LOCUS       XP_011533481            1025 aa            linear   PRI 05-AUG-2025
DEFINITION  RNA-binding protein 26 isoform X1 [Homo sapiens].
ACCESSION   XP_011533481
VERSION     XP_011533481.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535179.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1025
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1025
                     /product="RNA-binding protein 26 isoform X1"
                     /calculated_mol_wt=115352
     Region          11..76
                     /region_name="PWI"
                     /note="PWI domain; pfam01480"
                     /db_xref="CDD:460224"
     Region          <294..314
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Region          546..621
                     /region_name="RRM1_RBM26"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     RNA-binding protein 26 (RBM26); cd12516"
                     /db_xref="CDD:409938"
     Region          717..>809
                     /region_name="DR0291"
                     /note="Predicted nucleic acid-binding protein DR0291,
                     contains C4-type Zn-ribbon domain [General function
                     prediction only]; COG1579"
                     /db_xref="CDD:441187"
     Region          901..972
                     /region_name="RRM2_RBM26_like"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     RNA-binding protein 26 (RBM26) and similar proteins;
                     cd12258"
                     /db_xref="CDD:409703"
     CDS             1..1025
                     /gene="RBM26"
                     /gene_synonym="ARRS2; C13orf10; PPP1R132; PRO1777; SE70-2;
                     ZC3H17"
                     /coded_by="XM_011535179.3:482..3559"
                     /db_xref="GeneID:64062"
                     /db_xref="HGNC:HGNC:20327"
                     /db_xref="MIM:620081"
ORIGIN      
        1 mvskmiienf ealkswlskt lepicdadps alakyvlalv kkdksekelk alcidqldvf
       61 lqketqifve klfdavntks ylpppeqpss gslkveffph qekdikkeei tkeeerekkf
      121 srrlnhsppq sssryrenrs rderkkddrs rkrdydrnpp rrdsyrdryn rrrgrsrsys
      181 rsrsrswske rlrerdrdrs rtrsrsrtrs rerdlvkpky dldrtdplen nytpvssvps
      241 issghypvpt lsstitviap thhgnnttes wsefhedqvd hnsyvrppmp kkrcrdydek
      301 gfcmrgdmcp fdhgsdpvvv edvnlpgmlp fpaqppvveg ppppglpppp piltpppvnl
      361 rppvpppgpl ppslppvtdd isyslvltgp ppplpplqps gmdappnsat ssvptvvttg
      421 ihhqpppapp slftavfvlp dtydtdgynp eapsitntsr pmyrhrvhaq rpnligltsg
      481 dmdlpprekp pnkssmrivv dsesrkrtig sgepgvptkk twfdkpnfnr tnspgfqkkv
      541 qfgnentkle lrkvppelnn isklnehfsr fgtlvnlqva yngdpegali qfatyeeakk
      601 aissteavln nrfikvywhr egstqqlqtt spkvmqplvq qpilpvvkqs vkerlgpvps
      661 stiepaeaqs assdlpqnvt klsvkdrlgf vskpsvsate kvlststglt ktvynpaalk
      721 aaqktllvst savdnneaqk kkqealklqq dvrkrkqeil ekhietqkml iskleknktm
      781 ksedkaeimk tlevltknit klkdevkaas pgrclpksik tktqmqkell dteldlykkm
      841 qageevtelr rkytelqlea akrgilssgr grgihsrgrg avhgrgrgrg rgrgvpghav
      901 vdhrpralei saftesdred llphfaqyge iedcqiddss lhavitfktr aeaeaaavhg
      961 arfkgqdlkl awnkpvtnis aveteevepd eeeiiplsfh efelngeksr rapgiryfek
     1021 feiav
//
LOCUS       XP_047286457            1022 aa            linear   PRI 05-AUG-2025
DEFINITION  RNA-binding protein 26 isoform X2 [Homo sapiens].
ACCESSION   XP_047286457
VERSION     XP_047286457.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430501.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1022
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1022
                     /product="RNA-binding protein 26 isoform X2"
                     /calculated_mol_wt=115130
     Region          11..76
                     /region_name="PWI"
                     /note="PWI domain; pfam01480"
                     /db_xref="CDD:460224"
     Region          <294..314
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Region          546..621
                     /region_name="RRM1_RBM26"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     RNA-binding protein 26 (RBM26); cd12516"
                     /db_xref="CDD:409938"
     Region          717..>809
                     /region_name="DR0291"
                     /note="Predicted nucleic acid-binding protein DR0291,
                     contains C4-type Zn-ribbon domain [General function
                     prediction only]; COG1579"
                     /db_xref="CDD:441187"
     Region          901..972
                     /region_name="RRM2_RBM26_like"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     RNA-binding protein 26 (RBM26) and similar proteins;
                     cd12258"
                     /db_xref="CDD:409703"
     CDS             1..1022
                     /gene="RBM26"
                     /gene_synonym="ARRS2; C13orf10; PPP1R132; PRO1777; SE70-2;
                     ZC3H17"
                     /coded_by="XM_047430501.1:482..3550"
                     /db_xref="GeneID:64062"
                     /db_xref="HGNC:HGNC:20327"
                     /db_xref="MIM:620081"
ORIGIN      
        1 mvskmiienf ealkswlskt lepicdadps alakyvlalv kkdksekelk alcidqldvf
       61 lqketqifve klfdavntks ylpppeqpss gslkveffph qekdikkeei tkeeerekkf
      121 srrlnhsppq sssryrenrs rderkkddrs rkrdydrnpp rrdsyrdryn rrrgrsrsys
      181 rsrsrswske rlrerdrdrs rtrsrsrtrs rerdlvkpky dldrtdplen nytpvssvps
      241 issghypvpt lsstitviap thhgnnttes wsefhedqvd hnsyvrppmp kkrcrdydek
      301 gfcmrgdmcp fdhgsdpvvv edvnlpgmlp fpaqppvveg ppppglpppp piltpppvnl
      361 rppvpppgpl ppslppvtdd isyslvltgp ppplpplqps gmdappnsat ssvptvvttg
      421 ihhqpppapp slftavfvlp dtydtdgynp eapsitntsr pmyrhrvhaq rpnligltsg
      481 dmdlpprekp pnkssmrivv dsesrkrtig sgepgvptkk twfdkpnfnr tnspgfqkkv
      541 qfgnentkle lrkvppelnn isklnehfsr fgtlvnlqva yngdpegali qfatyeeakk
      601 aissteavln nrfikvywhr egstqqlqtt spkvmqplvq qpilpvvkqs vkerlgpvps
      661 stiepaeaqs assdlpqnvt klsvkdrlgf vskpsvsate kvlststglt ktvynpaalk
      721 aaqktllvst savdnneaqk kkqealklqq dvrkrkqeil ekhietqkml iskleknktm
      781 ksedkaeimk tlevltknit klkdevkaas pgrclpksik tktqmqkell dteldlykkm
      841 qageevtelr rkytelqlea akrgilssgr grgihsrgrg avhgrgrgrg rgrgvpghav
      901 vdhrpralei saftesdred llphfaqyge iedcqiddss lhavitfktr aeaeaaavhg
      961 arfkgqdlkl awnkpvtnis aveteevepd eeefqeeslv ddsllqddde eeednesrsw
     1021 rr
//
LOCUS       XP_011533483            1022 aa            linear   PRI 05-AUG-2025
DEFINITION  RNA-binding protein 26 isoform X3 [Homo sapiens].
ACCESSION   XP_011533483
VERSION     XP_011533483.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535181.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1022
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1022
                     /product="RNA-binding protein 26 isoform X3"
                     /calculated_mol_wt=114994
     Region          11..76
                     /region_name="PWI"
                     /note="PWI domain; pfam01480"
                     /db_xref="CDD:460224"
     Region          <294..314
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Region          546..621
                     /region_name="RRM1_RBM26"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     RNA-binding protein 26 (RBM26); cd12516"
                     /db_xref="CDD:409938"
     Region          714..>806
                     /region_name="DR0291"
                     /note="Predicted nucleic acid-binding protein DR0291,
                     contains C4-type Zn-ribbon domain [General function
                     prediction only]; COG1579"
                     /db_xref="CDD:441187"
     Region          898..969
                     /region_name="RRM2_RBM26_like"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     RNA-binding protein 26 (RBM26) and similar proteins;
                     cd12258"
                     /db_xref="CDD:409703"
     CDS             1..1022
                     /gene="RBM26"
                     /gene_synonym="ARRS2; C13orf10; PPP1R132; PRO1777; SE70-2;
                     ZC3H17"
                     /coded_by="XM_011535181.3:482..3550"
                     /db_xref="GeneID:64062"
                     /db_xref="HGNC:HGNC:20327"
                     /db_xref="MIM:620081"
ORIGIN      
        1 mvskmiienf ealkswlskt lepicdadps alakyvlalv kkdksekelk alcidqldvf
       61 lqketqifve klfdavntks ylpppeqpss gslkveffph qekdikkeei tkeeerekkf
      121 srrlnhsppq sssryrenrs rderkkddrs rkrdydrnpp rrdsyrdryn rrrgrsrsys
      181 rsrsrswske rlrerdrdrs rtrsrsrtrs rerdlvkpky dldrtdplen nytpvssvps
      241 issghypvpt lsstitviap thhgnnttes wsefhedqvd hnsyvrppmp kkrcrdydek
      301 gfcmrgdmcp fdhgsdpvvv edvnlpgmlp fpaqppvveg ppppglpppp piltpppvnl
      361 rppvpppgpl ppslppvtdd isyslvltgp ppplpplqps gmdappnsat ssvptvvttg
      421 ihhqpppapp slftavfvlp dtydtdgynp eapsitntsr pmyrhrvhaq rpnligltsg
      481 dmdlpprekp pnkssmrivv dsesrkrtig sgepgvptkk twfdkpnfnr tnspgfqkkv
      541 qfgnentkle lrkvppelnn isklnehfsr fgtlvnlqva yngdpegali qfatyeeakk
      601 aissteavln nrfikvywhr egstqqlqtt spkplvqqpi lpvvkqsvke rlgpvpssti
      661 epaeaqsass dlpqnvtkls vkdrlgfvsk psvsatekvl ststgltktv ynpaalkaaq
      721 ktllvstsav dnneaqkkkq ealklqqdvr krkqeilekh ietqkmlisk leknktmkse
      781 dkaeimktle vltknitklk devkaaspgr clpksiktkt qmqkelldte ldlykkmqag
      841 eevtelrrky telqleaakr gilssgrgrg ihsrgrgavh grgrgrgrgr gvpghavvdh
      901 rpraleisaf tesdredllp hfaqygeied cqiddsslha vitfktraea eaaavhgarf
      961 kgqdlklawn kpvtnisave teevepdeee iiplsfhefe lngeksrrap giryfekfei
     1021 av
//
LOCUS       XP_011533484            1020 aa            linear   PRI 05-AUG-2025
DEFINITION  RNA-binding protein 26 isoform X4 [Homo sapiens].
ACCESSION   XP_011533484
VERSION     XP_011533484.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535182.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1020
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1020
                     /product="RNA-binding protein 26 isoform X4"
                     /calculated_mol_wt=114797
     Region          11..76
                     /region_name="PWI"
                     /note="PWI domain; pfam01480"
                     /db_xref="CDD:460224"
     Region          <294..314
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Region          541..616
                     /region_name="RRM1_RBM26"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     RNA-binding protein 26 (RBM26); cd12516"
                     /db_xref="CDD:409938"
     Region          712..>804
                     /region_name="DR0291"
                     /note="Predicted nucleic acid-binding protein DR0291,
                     contains C4-type Zn-ribbon domain [General function
                     prediction only]; COG1579"
                     /db_xref="CDD:441187"
     Region          896..967
                     /region_name="RRM2_RBM26_like"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     RNA-binding protein 26 (RBM26) and similar proteins;
                     cd12258"
                     /db_xref="CDD:409703"
     CDS             1..1020
                     /gene="RBM26"
                     /gene_synonym="ARRS2; C13orf10; PPP1R132; PRO1777; SE70-2;
                     ZC3H17"
                     /coded_by="XM_011535182.3:482..3544"
                     /db_xref="GeneID:64062"
                     /db_xref="HGNC:HGNC:20327"
                     /db_xref="MIM:620081"
ORIGIN      
        1 mvskmiienf ealkswlskt lepicdadps alakyvlalv kkdksekelk alcidqldvf
       61 lqketqifve klfdavntks ylpppeqpss gslkveffph qekdikkeei tkeeerekkf
      121 srrlnhsppq sssryrenrs rderkkddrs rkrdydrnpp rrdsyrdryn rrrgrsrsys
      181 rsrsrswske rlrerdrdrs rtrsrsrtrs rerdlvkpky dldrtdplen nytpvssvps
      241 issghypvpt lsstitviap thhgnnttes wsefhedqvd hnsyvrppmp kkrcrdydek
      301 gfcmrgdmcp fdhgsdpvvv edvnlpgmlp fpaqppvveg ppppglpppp piltpppvnl
      361 rppvpppgpl ppslppvtdd isyslvltgp ppplpplqps gmdappnsat ssvptvvttg
      421 ihhqpppapp slftadtydt dgynpeapsi tntsrpmyrh rvhaqrpnli gltsgdmdlp
      481 prekppnkss mrivvdsesr krtigsgepg vptkktwfdk pnfnrtnspg fqkkvqfgne
      541 ntklelrkvp pelnniskln ehfsrfgtlv nlqvayngdp egaliqfaty eeakkaisst
      601 eavlnnrfik vywhregstq qlqttspkvm qplvqqpilp vvkqsvkerl gpvpsstiep
      661 aeaqsassdl pqnvtklsvk drlgfvskps vsatekvlst stgltktvyn paalkaaqkt
      721 llvstsavdn neaqkkkqea lklqqdvrkr kqeilekhie tqkmliskle knktmksedk
      781 aeimktlevl tknitklkde vkaaspgrcl pksiktktqm qkelldteld lykkmqagee
      841 vtelrrkyte lqleaakrgi lssgrgrgih srgrgavhgr grgrgrgrgv pghavvdhrp
      901 raleisafte sdredllphf aqygeiedcq iddsslhavi tfktraeaea aavhgarfkg
      961 qdlklawnkp vtnisavete evepdeeeii plsfhefeln geksrrapgi ryfekfeiav
//
LOCUS       XP_047286458            1019 aa            linear   PRI 05-AUG-2025
DEFINITION  RNA-binding protein 26 isoform X5 [Homo sapiens].
ACCESSION   XP_047286458
VERSION     XP_047286458.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430502.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1019
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1019
                     /product="RNA-binding protein 26 isoform X5"
                     /calculated_mol_wt=114771
     Region          11..76
                     /region_name="PWI"
                     /note="PWI domain; pfam01480"
                     /db_xref="CDD:460224"
     Region          <294..314
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Region          546..621
                     /region_name="RRM1_RBM26"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     RNA-binding protein 26 (RBM26); cd12516"
                     /db_xref="CDD:409938"
     Region          714..>806
                     /region_name="DR0291"
                     /note="Predicted nucleic acid-binding protein DR0291,
                     contains C4-type Zn-ribbon domain [General function
                     prediction only]; COG1579"
                     /db_xref="CDD:441187"
     Region          898..969
                     /region_name="RRM2_RBM26_like"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     RNA-binding protein 26 (RBM26) and similar proteins;
                     cd12258"
                     /db_xref="CDD:409703"
     CDS             1..1019
                     /gene="RBM26"
                     /gene_synonym="ARRS2; C13orf10; PPP1R132; PRO1777; SE70-2;
                     ZC3H17"
                     /coded_by="XM_047430502.1:482..3541"
                     /db_xref="GeneID:64062"
                     /db_xref="HGNC:HGNC:20327"
                     /db_xref="MIM:620081"
ORIGIN      
        1 mvskmiienf ealkswlskt lepicdadps alakyvlalv kkdksekelk alcidqldvf
       61 lqketqifve klfdavntks ylpppeqpss gslkveffph qekdikkeei tkeeerekkf
      121 srrlnhsppq sssryrenrs rderkkddrs rkrdydrnpp rrdsyrdryn rrrgrsrsys
      181 rsrsrswske rlrerdrdrs rtrsrsrtrs rerdlvkpky dldrtdplen nytpvssvps
      241 issghypvpt lsstitviap thhgnnttes wsefhedqvd hnsyvrppmp kkrcrdydek
      301 gfcmrgdmcp fdhgsdpvvv edvnlpgmlp fpaqppvveg ppppglpppp piltpppvnl
      361 rppvpppgpl ppslppvtdd isyslvltgp ppplpplqps gmdappnsat ssvptvvttg
      421 ihhqpppapp slftavfvlp dtydtdgynp eapsitntsr pmyrhrvhaq rpnligltsg
      481 dmdlpprekp pnkssmrivv dsesrkrtig sgepgvptkk twfdkpnfnr tnspgfqkkv
      541 qfgnentkle lrkvppelnn isklnehfsr fgtlvnlqva yngdpegali qfatyeeakk
      601 aissteavln nrfikvywhr egstqqlqtt spkplvqqpi lpvvkqsvke rlgpvpssti
      661 epaeaqsass dlpqnvtkls vkdrlgfvsk psvsatekvl ststgltktv ynpaalkaaq
      721 ktllvstsav dnneaqkkkq ealklqqdvr krkqeilekh ietqkmlisk leknktmkse
      781 dkaeimktle vltknitklk devkaaspgr clpksiktkt qmqkelldte ldlykkmqag
      841 eevtelrrky telqleaakr gilssgrgrg ihsrgrgavh grgrgrgrgr gvpghavvdh
      901 rpraleisaf tesdredllp hfaqygeied cqiddsslha vitfktraea eaaavhgarf
      961 kgqdlklawn kpvtnisave teevepdeee fqeeslvdds llqdddeeee dnesrswrr
//
LOCUS       XP_047286459            1017 aa            linear   PRI 05-AUG-2025
DEFINITION  RNA-binding protein 26 isoform X6 [Homo sapiens].
ACCESSION   XP_047286459
VERSION     XP_047286459.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430503.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1017
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1017
                     /product="RNA-binding protein 26 isoform X6"
                     /calculated_mol_wt=114574
     Region          11..76
                     /region_name="PWI"
                     /note="PWI domain; pfam01480"
                     /db_xref="CDD:460224"
     Region          <294..314
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Region          541..616
                     /region_name="RRM1_RBM26"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     RNA-binding protein 26 (RBM26); cd12516"
                     /db_xref="CDD:409938"
     Region          712..>804
                     /region_name="DR0291"
                     /note="Predicted nucleic acid-binding protein DR0291,
                     contains C4-type Zn-ribbon domain [General function
                     prediction only]; COG1579"
                     /db_xref="CDD:441187"
     Region          896..967
                     /region_name="RRM2_RBM26_like"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     RNA-binding protein 26 (RBM26) and similar proteins;
                     cd12258"
                     /db_xref="CDD:409703"
     CDS             1..1017
                     /gene="RBM26"
                     /gene_synonym="ARRS2; C13orf10; PPP1R132; PRO1777; SE70-2;
                     ZC3H17"
                     /coded_by="XM_047430503.1:482..3535"
                     /db_xref="GeneID:64062"
                     /db_xref="HGNC:HGNC:20327"
                     /db_xref="MIM:620081"
ORIGIN      
        1 mvskmiienf ealkswlskt lepicdadps alakyvlalv kkdksekelk alcidqldvf
       61 lqketqifve klfdavntks ylpppeqpss gslkveffph qekdikkeei tkeeerekkf
      121 srrlnhsppq sssryrenrs rderkkddrs rkrdydrnpp rrdsyrdryn rrrgrsrsys
      181 rsrsrswske rlrerdrdrs rtrsrsrtrs rerdlvkpky dldrtdplen nytpvssvps
      241 issghypvpt lsstitviap thhgnnttes wsefhedqvd hnsyvrppmp kkrcrdydek
      301 gfcmrgdmcp fdhgsdpvvv edvnlpgmlp fpaqppvveg ppppglpppp piltpppvnl
      361 rppvpppgpl ppslppvtdd isyslvltgp ppplpplqps gmdappnsat ssvptvvttg
      421 ihhqpppapp slftadtydt dgynpeapsi tntsrpmyrh rvhaqrpnli gltsgdmdlp
      481 prekppnkss mrivvdsesr krtigsgepg vptkktwfdk pnfnrtnspg fqkkvqfgne
      541 ntklelrkvp pelnniskln ehfsrfgtlv nlqvayngdp egaliqfaty eeakkaisst
      601 eavlnnrfik vywhregstq qlqttspkvm qplvqqpilp vvkqsvkerl gpvpsstiep
      661 aeaqsassdl pqnvtklsvk drlgfvskps vsatekvlst stgltktvyn paalkaaqkt
      721 llvstsavdn neaqkkkqea lklqqdvrkr kqeilekhie tqkmliskle knktmksedk
      781 aeimktlevl tknitklkde vkaaspgrcl pksiktktqm qkelldteld lykkmqagee
      841 vtelrrkyte lqleaakrgi lssgrgrgih srgrgavhgr grgrgrgrgv pghavvdhrp
      901 raleisafte sdredllphf aqygeiedcq iddsslhavi tfktraeaea aavhgarfkg
      961 qdlklawnkp vtnisavete evepdeeefq eeslvddsll qdddeeeedn esrswrr
//
LOCUS       XP_016876178            1017 aa            linear   PRI 05-AUG-2025
DEFINITION  RNA-binding protein 26 isoform X7 [Homo sapiens].
ACCESSION   XP_016876178
VERSION     XP_016876178.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020689.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1017
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1017
                     /product="RNA-binding protein 26 isoform X7"
                     /calculated_mol_wt=114438
     Region          11..76
                     /region_name="PWI"
                     /note="PWI domain; pfam01480"
                     /db_xref="CDD:460224"
     Region          <294..314
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Region          541..616
                     /region_name="RRM1_RBM26"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     RNA-binding protein 26 (RBM26); cd12516"
                     /db_xref="CDD:409938"
     Region          709..>801
                     /region_name="DR0291"
                     /note="Predicted nucleic acid-binding protein DR0291,
                     contains C4-type Zn-ribbon domain [General function
                     prediction only]; COG1579"
                     /db_xref="CDD:441187"
     Region          893..964
                     /region_name="RRM2_RBM26_like"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     RNA-binding protein 26 (RBM26) and similar proteins;
                     cd12258"
                     /db_xref="CDD:409703"
     CDS             1..1017
                     /gene="RBM26"
                     /gene_synonym="ARRS2; C13orf10; PPP1R132; PRO1777; SE70-2;
                     ZC3H17"
                     /coded_by="XM_017020689.3:482..3535"
                     /db_xref="GeneID:64062"
                     /db_xref="HGNC:HGNC:20327"
                     /db_xref="MIM:620081"
ORIGIN      
        1 mvskmiienf ealkswlskt lepicdadps alakyvlalv kkdksekelk alcidqldvf
       61 lqketqifve klfdavntks ylpppeqpss gslkveffph qekdikkeei tkeeerekkf
      121 srrlnhsppq sssryrenrs rderkkddrs rkrdydrnpp rrdsyrdryn rrrgrsrsys
      181 rsrsrswske rlrerdrdrs rtrsrsrtrs rerdlvkpky dldrtdplen nytpvssvps
      241 issghypvpt lsstitviap thhgnnttes wsefhedqvd hnsyvrppmp kkrcrdydek
      301 gfcmrgdmcp fdhgsdpvvv edvnlpgmlp fpaqppvveg ppppglpppp piltpppvnl
      361 rppvpppgpl ppslppvtdd isyslvltgp ppplpplqps gmdappnsat ssvptvvttg
      421 ihhqpppapp slftadtydt dgynpeapsi tntsrpmyrh rvhaqrpnli gltsgdmdlp
      481 prekppnkss mrivvdsesr krtigsgepg vptkktwfdk pnfnrtnspg fqkkvqfgne
      541 ntklelrkvp pelnniskln ehfsrfgtlv nlqvayngdp egaliqfaty eeakkaisst
      601 eavlnnrfik vywhregstq qlqttspkpl vqqpilpvvk qsvkerlgpv psstiepaea
      661 qsassdlpqn vtklsvkdrl gfvskpsvsa tekvlststg ltktvynpaa lkaaqktllv
      721 stsavdnnea qkkkqealkl qqdvrkrkqe ilekhietqk mliskleknk tmksedkaei
      781 mktlevltkn itklkdevka aspgrclpks iktktqmqke lldteldlyk kmqageevte
      841 lrrkytelql eaakrgilss grgrgihsrg rgavhgrgrg rgrgrgvpgh avvdhrpral
      901 eisaftesdr edllphfaqy geiedcqidd sslhavitfk traeaeaaav hgarfkgqdl
      961 klawnkpvtn isaveteeve pdeeeiipls fhefelngek srrapgiryf ekfeiav
//
LOCUS       XP_011533486            1015 aa            linear   PRI 05-AUG-2025
DEFINITION  RNA-binding protein 26 isoform X8 [Homo sapiens].
ACCESSION   XP_011533486
VERSION     XP_011533486.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535184.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1015
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1015
                     /product="RNA-binding protein 26 isoform X8"
                     /calculated_mol_wt=114245
     Region          11..76
                     /region_name="PWI"
                     /note="PWI domain; pfam01480"
                     /db_xref="CDD:460224"
     Region          <294..314
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Region          536..611
                     /region_name="RRM1_RBM26"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     RNA-binding protein 26 (RBM26); cd12516"
                     /db_xref="CDD:409938"
     Region          707..>799
                     /region_name="DR0291"
                     /note="Predicted nucleic acid-binding protein DR0291,
                     contains C4-type Zn-ribbon domain [General function
                     prediction only]; COG1579"
                     /db_xref="CDD:441187"
     Region          891..962
                     /region_name="RRM2_RBM26_like"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     RNA-binding protein 26 (RBM26) and similar proteins;
                     cd12258"
                     /db_xref="CDD:409703"
     CDS             1..1015
                     /gene="RBM26"
                     /gene_synonym="ARRS2; C13orf10; PPP1R132; PRO1777; SE70-2;
                     ZC3H17"
                     /coded_by="XM_011535184.3:482..3529"
                     /db_xref="GeneID:64062"
                     /db_xref="HGNC:HGNC:20327"
                     /db_xref="MIM:620081"
ORIGIN      
        1 mvskmiienf ealkswlskt lepicdadps alakyvlalv kkdksekelk alcidqldvf
       61 lqketqifve klfdavntks ylpppeqpss gslkveffph qekdikkeei tkeeerekkf
      121 srrlnhsppq sssryrenrs rderkkddrs rkrdydrnpp rrdsyrdryn rrrgrsrsys
      181 rsrsrswske rlrerdrdrs rtrsrsrtrs rerdlvkpky dldrtdplen nytpvssvps
      241 issghypvpt lsstitviap thhgnnttes wsefhedqvd hnsyvrppmp kkrcrdydek
      301 gfcmrgdmcp fdhgsdpvvv edvnlpgmlp fpaqppvveg ppppglpppp piltpppvnl
      361 rppvpppgpl ppslppvtgp ppplpplqps gmdappnsat ssvptvvttg ihhqpppapp
      421 slftavfvlp dtydtdgynp eapsitntsr pmyrhrvhaq rpnligltsg dmdlpprekp
      481 pnkssmrivv dsesrkrtig sgepgvptkk twfdkpnfnr tnspgfqkkv qfgnentkle
      541 lrkvppelnn isklnehfsr fgtlvnlqva yngdpegali qfatyeeakk aissteavln
      601 nrfikvywhr egstqqlqtt spkvmqplvq qpilpvvkqs vkerlgpvps stiepaeaqs
      661 assdlpqnvt klsvkdrlgf vskpsvsate kvlststglt ktvynpaalk aaqktllvst
      721 savdnneaqk kkqealklqq dvrkrkqeil ekhietqkml iskleknktm ksedkaeimk
      781 tlevltknit klkdevkaas pgrclpksik tktqmqkell dteldlykkm qageevtelr
      841 rkytelqlea akrgilssgr grgihsrgrg avhgrgrgrg rgrgvpghav vdhrpralei
      901 saftesdred llphfaqyge iedcqiddss lhavitfktr aeaeaaavhg arfkgqdlkl
      961 awnkpvtnis aveteevepd eeeiiplsfh efelngeksr rapgiryfek feiav
//
LOCUS       XP_047286460            1014 aa            linear   PRI 05-AUG-2025
DEFINITION  RNA-binding protein 26 isoform X9 [Homo sapiens].
ACCESSION   XP_047286460
VERSION     XP_047286460.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430504.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1014
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1014
                     /product="RNA-binding protein 26 isoform X9"
                     /calculated_mol_wt=114215
     Region          11..76
                     /region_name="PWI"
                     /note="PWI domain; pfam01480"
                     /db_xref="CDD:460224"
     Region          <294..314
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Region          541..616
                     /region_name="RRM1_RBM26"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     RNA-binding protein 26 (RBM26); cd12516"
                     /db_xref="CDD:409938"
     Region          709..>801
                     /region_name="DR0291"
                     /note="Predicted nucleic acid-binding protein DR0291,
                     contains C4-type Zn-ribbon domain [General function
                     prediction only]; COG1579"
                     /db_xref="CDD:441187"
     Region          893..964
                     /region_name="RRM2_RBM26_like"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     RNA-binding protein 26 (RBM26) and similar proteins;
                     cd12258"
                     /db_xref="CDD:409703"
     CDS             1..1014
                     /gene="RBM26"
                     /gene_synonym="ARRS2; C13orf10; PPP1R132; PRO1777; SE70-2;
                     ZC3H17"
                     /coded_by="XM_047430504.1:482..3526"
                     /db_xref="GeneID:64062"
                     /db_xref="HGNC:HGNC:20327"
                     /db_xref="MIM:620081"
ORIGIN      
        1 mvskmiienf ealkswlskt lepicdadps alakyvlalv kkdksekelk alcidqldvf
       61 lqketqifve klfdavntks ylpppeqpss gslkveffph qekdikkeei tkeeerekkf
      121 srrlnhsppq sssryrenrs rderkkddrs rkrdydrnpp rrdsyrdryn rrrgrsrsys
      181 rsrsrswske rlrerdrdrs rtrsrsrtrs rerdlvkpky dldrtdplen nytpvssvps
      241 issghypvpt lsstitviap thhgnnttes wsefhedqvd hnsyvrppmp kkrcrdydek
      301 gfcmrgdmcp fdhgsdpvvv edvnlpgmlp fpaqppvveg ppppglpppp piltpppvnl
      361 rppvpppgpl ppslppvtdd isyslvltgp ppplpplqps gmdappnsat ssvptvvttg
      421 ihhqpppapp slftadtydt dgynpeapsi tntsrpmyrh rvhaqrpnli gltsgdmdlp
      481 prekppnkss mrivvdsesr krtigsgepg vptkktwfdk pnfnrtnspg fqkkvqfgne
      541 ntklelrkvp pelnniskln ehfsrfgtlv nlqvayngdp egaliqfaty eeakkaisst
      601 eavlnnrfik vywhregstq qlqttspkpl vqqpilpvvk qsvkerlgpv psstiepaea
      661 qsassdlpqn vtklsvkdrl gfvskpsvsa tekvlststg ltktvynpaa lkaaqktllv
      721 stsavdnnea qkkkqealkl qqdvrkrkqe ilekhietqk mliskleknk tmksedkaei
      781 mktlevltkn itklkdevka aspgrclpks iktktqmqke lldteldlyk kmqageevte
      841 lrrkytelql eaakrgilss grgrgihsrg rgavhgrgrg rgrgrgvpgh avvdhrpral
      901 eisaftesdr edllphfaqy geiedcqidd sslhavitfk traeaeaaav hgarfkgqdl
      961 klawnkpvtn isaveteeve pdeeefqees lvddsllqdd deeeednesr swrr
//
LOCUS       XP_047286462            1012 aa            linear   PRI 05-AUG-2025
DEFINITION  RNA-binding protein 26 isoform X10 [Homo sapiens].
ACCESSION   XP_047286462
VERSION     XP_047286462.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430506.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1012
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1012
                     /product="RNA-binding protein 26 isoform X10"
                     /calculated_mol_wt=114022
     Region          11..76
                     /region_name="PWI"
                     /note="PWI domain; pfam01480"
                     /db_xref="CDD:460224"
     Region          <294..314
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Region          536..611
                     /region_name="RRM1_RBM26"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     RNA-binding protein 26 (RBM26); cd12516"
                     /db_xref="CDD:409938"
     Region          707..>799
                     /region_name="DR0291"
                     /note="Predicted nucleic acid-binding protein DR0291,
                     contains C4-type Zn-ribbon domain [General function
                     prediction only]; COG1579"
                     /db_xref="CDD:441187"
     Region          891..962
                     /region_name="RRM2_RBM26_like"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     RNA-binding protein 26 (RBM26) and similar proteins;
                     cd12258"
                     /db_xref="CDD:409703"
     CDS             1..1012
                     /gene="RBM26"
                     /gene_synonym="ARRS2; C13orf10; PPP1R132; PRO1777; SE70-2;
                     ZC3H17"
                     /coded_by="XM_047430506.1:482..3520"
                     /db_xref="GeneID:64062"
                     /db_xref="HGNC:HGNC:20327"
                     /db_xref="MIM:620081"
ORIGIN      
        1 mvskmiienf ealkswlskt lepicdadps alakyvlalv kkdksekelk alcidqldvf
       61 lqketqifve klfdavntks ylpppeqpss gslkveffph qekdikkeei tkeeerekkf
      121 srrlnhsppq sssryrenrs rderkkddrs rkrdydrnpp rrdsyrdryn rrrgrsrsys
      181 rsrsrswske rlrerdrdrs rtrsrsrtrs rerdlvkpky dldrtdplen nytpvssvps
      241 issghypvpt lsstitviap thhgnnttes wsefhedqvd hnsyvrppmp kkrcrdydek
      301 gfcmrgdmcp fdhgsdpvvv edvnlpgmlp fpaqppvveg ppppglpppp piltpppvnl
      361 rppvpppgpl ppslppvtgp ppplpplqps gmdappnsat ssvptvvttg ihhqpppapp
      421 slftavfvlp dtydtdgynp eapsitntsr pmyrhrvhaq rpnligltsg dmdlpprekp
      481 pnkssmrivv dsesrkrtig sgepgvptkk twfdkpnfnr tnspgfqkkv qfgnentkle
      541 lrkvppelnn isklnehfsr fgtlvnlqva yngdpegali qfatyeeakk aissteavln
      601 nrfikvywhr egstqqlqtt spkvmqplvq qpilpvvkqs vkerlgpvps stiepaeaqs
      661 assdlpqnvt klsvkdrlgf vskpsvsate kvlststglt ktvynpaalk aaqktllvst
      721 savdnneaqk kkqealklqq dvrkrkqeil ekhietqkml iskleknktm ksedkaeimk
      781 tlevltknit klkdevkaas pgrclpksik tktqmqkell dteldlykkm qageevtelr
      841 rkytelqlea akrgilssgr grgihsrgrg avhgrgrgrg rgrgvpghav vdhrpralei
      901 saftesdred llphfaqyge iedcqiddss lhavitfktr aeaeaaavhg arfkgqdlkl
      961 awnkpvtnis aveteevepd eeefqeeslv ddsllqddde eeednesrsw rr
//
LOCUS       XP_011533488            1010 aa            linear   PRI 05-AUG-2025
DEFINITION  RNA-binding protein 26 isoform X11 [Homo sapiens].
ACCESSION   XP_011533488
VERSION     XP_011533488.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535186.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1010
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1010
                     /product="RNA-binding protein 26 isoform X11"
                     /calculated_mol_wt=113689
     Region          11..76
                     /region_name="PWI"
                     /note="PWI domain; pfam01480"
                     /db_xref="CDD:460224"
     Region          <294..314
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Region          531..606
                     /region_name="RRM1_RBM26"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     RNA-binding protein 26 (RBM26); cd12516"
                     /db_xref="CDD:409938"
     Region          702..>794
                     /region_name="DR0291"
                     /note="Predicted nucleic acid-binding protein DR0291,
                     contains C4-type Zn-ribbon domain [General function
                     prediction only]; COG1579"
                     /db_xref="CDD:441187"
     Region          886..957
                     /region_name="RRM2_RBM26_like"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     RNA-binding protein 26 (RBM26) and similar proteins;
                     cd12258"
                     /db_xref="CDD:409703"
     CDS             1..1010
                     /gene="RBM26"
                     /gene_synonym="ARRS2; C13orf10; PPP1R132; PRO1777; SE70-2;
                     ZC3H17"
                     /coded_by="XM_011535186.4:482..3514"
                     /db_xref="GeneID:64062"
                     /db_xref="HGNC:HGNC:20327"
                     /db_xref="MIM:620081"
ORIGIN      
        1 mvskmiienf ealkswlskt lepicdadps alakyvlalv kkdksekelk alcidqldvf
       61 lqketqifve klfdavntks ylpppeqpss gslkveffph qekdikkeei tkeeerekkf
      121 srrlnhsppq sssryrenrs rderkkddrs rkrdydrnpp rrdsyrdryn rrrgrsrsys
      181 rsrsrswske rlrerdrdrs rtrsrsrtrs rerdlvkpky dldrtdplen nytpvssvps
      241 issghypvpt lsstitviap thhgnnttes wsefhedqvd hnsyvrppmp kkrcrdydek
      301 gfcmrgdmcp fdhgsdpvvv edvnlpgmlp fpaqppvveg ppppglpppp piltpppvnl
      361 rppvpppgpl ppslppvtgp ppplpplqps gmdappnsat ssvptvvttg ihhqpppapp
      421 slftadtydt dgynpeapsi tntsrpmyrh rvhaqrpnli gltsgdmdlp prekppnkss
      481 mrivvdsesr krtigsgepg vptkktwfdk pnfnrtnspg fqkkvqfgne ntklelrkvp
      541 pelnniskln ehfsrfgtlv nlqvayngdp egaliqfaty eeakkaisst eavlnnrfik
      601 vywhregstq qlqttspkvm qplvqqpilp vvkqsvkerl gpvpsstiep aeaqsassdl
      661 pqnvtklsvk drlgfvskps vsatekvlst stgltktvyn paalkaaqkt llvstsavdn
      721 neaqkkkqea lklqqdvrkr kqeilekhie tqkmliskle knktmksedk aeimktlevl
      781 tknitklkde vkaaspgrcl pksiktktqm qkelldteld lykkmqagee vtelrrkyte
      841 lqleaakrgi lssgrgrgih srgrgavhgr grgrgrgrgv pghavvdhrp raleisafte
      901 sdredllphf aqygeiedcq iddsslhavi tfktraeaea aavhgarfkg qdlklawnkp
      961 vtnisavete evepdeeeii plsfhefeln geksrrapgi ryfekfeiav
//
LOCUS       XP_047286463            1004 aa            linear   PRI 05-AUG-2025
DEFINITION  RNA-binding protein 26 isoform X12 [Homo sapiens].
ACCESSION   XP_047286463
VERSION     XP_047286463.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430507.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1004
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1004
                     /product="RNA-binding protein 26 isoform X12"
                     /calculated_mol_wt=113108
     Region          11..76
                     /region_name="PWI"
                     /note="PWI domain; pfam01480"
                     /db_xref="CDD:460224"
     Region          <294..314
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Region          531..606
                     /region_name="RRM1_RBM26"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     RNA-binding protein 26 (RBM26); cd12516"
                     /db_xref="CDD:409938"
     Region          699..>791
                     /region_name="DR0291"
                     /note="Predicted nucleic acid-binding protein DR0291,
                     contains C4-type Zn-ribbon domain [General function
                     prediction only]; COG1579"
                     /db_xref="CDD:441187"
     Region          883..954
                     /region_name="RRM2_RBM26_like"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     RNA-binding protein 26 (RBM26) and similar proteins;
                     cd12258"
                     /db_xref="CDD:409703"
     CDS             1..1004
                     /gene="RBM26"
                     /gene_synonym="ARRS2; C13orf10; PPP1R132; PRO1777; SE70-2;
                     ZC3H17"
                     /coded_by="XM_047430507.1:482..3496"
                     /db_xref="GeneID:64062"
                     /db_xref="HGNC:HGNC:20327"
                     /db_xref="MIM:620081"
ORIGIN      
        1 mvskmiienf ealkswlskt lepicdadps alakyvlalv kkdksekelk alcidqldvf
       61 lqketqifve klfdavntks ylpppeqpss gslkveffph qekdikkeei tkeeerekkf
      121 srrlnhsppq sssryrenrs rderkkddrs rkrdydrnpp rrdsyrdryn rrrgrsrsys
      181 rsrsrswske rlrerdrdrs rtrsrsrtrs rerdlvkpky dldrtdplen nytpvssvps
      241 issghypvpt lsstitviap thhgnnttes wsefhedqvd hnsyvrppmp kkrcrdydek
      301 gfcmrgdmcp fdhgsdpvvv edvnlpgmlp fpaqppvveg ppppglpppp piltpppvnl
      361 rppvpppgpl ppslppvtgp ppplpplqps gmdappnsat ssvptvvttg ihhqpppapp
      421 slftadtydt dgynpeapsi tntsrpmyrh rvhaqrpnli gltsgdmdlp prekppnkss
      481 mrivvdsesr krtigsgepg vptkktwfdk pnfnrtnspg fqkkvqfgne ntklelrkvp
      541 pelnniskln ehfsrfgtlv nlqvayngdp egaliqfaty eeakkaisst eavlnnrfik
      601 vywhregstq qlqttspkpl vqqpilpvvk qsvkerlgpv psstiepaea qsassdlpqn
      661 vtklsvkdrl gfvskpsvsa tekvlststg ltktvynpaa lkaaqktllv stsavdnnea
      721 qkkkqealkl qqdvrkrkqe ilekhietqk mliskleknk tmksedkaei mktlevltkn
      781 itklkdevka aspgrclpks iktktqmqke lldteldlyk kmqageevte lrrkytelql
      841 eaakrgilss grgrgihsrg rgavhgrgrg rgrgrgvpgh avvdhrpral eisaftesdr
      901 edllphfaqy geiedcqidd sslhavitfk traeaeaaav hgarfkgqdl klawnkpvtn
      961 isaveteeve pdeeefqees lvddsllqdd deeeednesr swrr
//
LOCUS       XP_047286464            1007 aa            linear   PRI 05-AUG-2025
DEFINITION  RNA-binding protein 26 isoform X13 [Homo sapiens].
ACCESSION   XP_047286464
VERSION     XP_047286464.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430508.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1007
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1007
                     /product="RNA-binding protein 26 isoform X13"
                     /calculated_mol_wt=113331
     Region          11..76
                     /region_name="PWI"
                     /note="PWI domain; pfam01480"
                     /db_xref="CDD:460224"
     Region          <294..314
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Region          531..606
                     /region_name="RRM1_RBM26"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     RNA-binding protein 26 (RBM26); cd12516"
                     /db_xref="CDD:409938"
     Region          699..>791
                     /region_name="DR0291"
                     /note="Predicted nucleic acid-binding protein DR0291,
                     contains C4-type Zn-ribbon domain [General function
                     prediction only]; COG1579"
                     /db_xref="CDD:441187"
     Region          883..954
                     /region_name="RRM2_RBM26_like"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     RNA-binding protein 26 (RBM26) and similar proteins;
                     cd12258"
                     /db_xref="CDD:409703"
     CDS             1..1007
                     /gene="RBM26"
                     /gene_synonym="ARRS2; C13orf10; PPP1R132; PRO1777; SE70-2;
                     ZC3H17"
                     /coded_by="XM_047430508.1:482..3505"
                     /db_xref="GeneID:64062"
                     /db_xref="HGNC:HGNC:20327"
                     /db_xref="MIM:620081"
ORIGIN      
        1 mvskmiienf ealkswlskt lepicdadps alakyvlalv kkdksekelk alcidqldvf
       61 lqketqifve klfdavntks ylpppeqpss gslkveffph qekdikkeei tkeeerekkf
      121 srrlnhsppq sssryrenrs rderkkddrs rkrdydrnpp rrdsyrdryn rrrgrsrsys
      181 rsrsrswske rlrerdrdrs rtrsrsrtrs rerdlvkpky dldrtdplen nytpvssvps
      241 issghypvpt lsstitviap thhgnnttes wsefhedqvd hnsyvrppmp kkrcrdydek
      301 gfcmrgdmcp fdhgsdpvvv edvnlpgmlp fpaqppvveg ppppglpppp piltpppvnl
      361 rppvpppgpl ppslppvtgp ppplpplqps gmdappnsat ssvptvvttg ihhqpppapp
      421 slftadtydt dgynpeapsi tntsrpmyrh rvhaqrpnli gltsgdmdlp prekppnkss
      481 mrivvdsesr krtigsgepg vptkktwfdk pnfnrtnspg fqkkvqfgne ntklelrkvp
      541 pelnniskln ehfsrfgtlv nlqvayngdp egaliqfaty eeakkaisst eavlnnrfik
      601 vywhregstq qlqttspkpl vqqpilpvvk qsvkerlgpv psstiepaea qsassdlpqn
      661 vtklsvkdrl gfvskpsvsa tekvlststg ltktvynpaa lkaaqktllv stsavdnnea
      721 qkkkqealkl qqdvrkrkqe ilekhietqk mliskleknk tmksedkaei mktlevltkn
      781 itklkdevka aspgrclpks iktktqmqke lldteldlyk kmqageevte lrrkytelql
      841 eaakrgilss grgrgihsrg rgavhgrgrg rgrgrgvpgh avvdhrpral eisaftesdr
      901 edllphfaqy geiedcqidd sslhavitfk traeaeaaav hgarfkgqdl klawnkpvtn
      961 isaveteeve pdeeeiipls fhefelngek srrapgiryf ekfeiav
//
LOCUS       XP_005266554            1000 aa            linear   PRI 05-AUG-2025
DEFINITION  RNA-binding protein 26 isoform X14 [Homo sapiens].
ACCESSION   XP_005266554
VERSION     XP_005266554.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266497.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1000
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1000
                     /product="RNA-binding protein 26 isoform X14"
                     /calculated_mol_wt=112400
     Region          11..76
                     /region_name="PWI"
                     /note="PWI domain; pfam01480"
                     /db_xref="CDD:460224"
     Region          <294..314
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Region          546..621
                     /region_name="RRM1_RBM26"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     RNA-binding protein 26 (RBM26); cd12516"
                     /db_xref="CDD:409938"
     Region          717..>809
                     /region_name="DR0291"
                     /note="Predicted nucleic acid-binding protein DR0291,
                     contains C4-type Zn-ribbon domain [General function
                     prediction only]; COG1579"
                     /db_xref="CDD:441187"
     Region          901..972
                     /region_name="RRM2_RBM26_like"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     RNA-binding protein 26 (RBM26) and similar proteins;
                     cd12258"
                     /db_xref="CDD:409703"
     CDS             1..1000
                     /gene="RBM26"
                     /gene_synonym="ARRS2; C13orf10; PPP1R132; PRO1777; SE70-2;
                     ZC3H17"
                     /coded_by="XM_005266497.3:482..3484"
                     /db_xref="GeneID:64062"
                     /db_xref="HGNC:HGNC:20327"
                     /db_xref="MIM:620081"
ORIGIN      
        1 mvskmiienf ealkswlskt lepicdadps alakyvlalv kkdksekelk alcidqldvf
       61 lqketqifve klfdavntks ylpppeqpss gslkveffph qekdikkeei tkeeerekkf
      121 srrlnhsppq sssryrenrs rderkkddrs rkrdydrnpp rrdsyrdryn rrrgrsrsys
      181 rsrsrswske rlrerdrdrs rtrsrsrtrs rerdlvkpky dldrtdplen nytpvssvps
      241 issghypvpt lsstitviap thhgnnttes wsefhedqvd hnsyvrppmp kkrcrdydek
      301 gfcmrgdmcp fdhgsdpvvv edvnlpgmlp fpaqppvveg ppppglpppp piltpppvnl
      361 rppvpppgpl ppslppvtdd isyslvltgp ppplpplqps gmdappnsat ssvptvvttg
      421 ihhqpppapp slftavfvlp dtydtdgynp eapsitntsr pmyrhrvhaq rpnligltsg
      481 dmdlpprekp pnkssmrivv dsesrkrtig sgepgvptkk twfdkpnfnr tnspgfqkkv
      541 qfgnentkle lrkvppelnn isklnehfsr fgtlvnlqva yngdpegali qfatyeeakk
      601 aissteavln nrfikvywhr egstqqlqtt spkvmqplvq qpilpvvkqs vkerlgpvps
      661 stiepaeaqs assdlpqnvt klsvkdrlgf vskpsvsate kvlststglt ktvynpaalk
      721 aaqktllvst savdnneaqk kkqealklqq dvrkrkqeil ekhietqkml iskleknktm
      781 ksedkaeimk tlevltknit klkdevkaas pgrclpksik tktqmqkell dteldlykkm
      841 qageevtelr rkytelqlea akrgilssgr grgihsrgrg avhgrgrgrg rgrgvpghav
      901 vdhrpralei saftesdred llphfaqyge iedcqiddss lhavitfktr aeaeaaavhg
      961 arfkgqdlkl awnkpvtnis aveteevepd eeeqreiiia
//
LOCUS       XP_006719920             999 aa            linear   PRI 05-AUG-2025
DEFINITION  RNA-binding protein 26 isoform X15 [Homo sapiens].
ACCESSION   XP_006719920
VERSION     XP_006719920.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006719857.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..999
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..999
                     /product="RNA-binding protein 26 isoform X15"
                     /calculated_mol_wt=112272
     Region          11..76
                     /region_name="PWI"
                     /note="PWI domain; pfam01480"
                     /db_xref="CDD:460224"
     Region          <294..314
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Region          546..621
                     /region_name="RRM1_RBM26"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     RNA-binding protein 26 (RBM26); cd12516"
                     /db_xref="CDD:409938"
     Region          717..>809
                     /region_name="DR0291"
                     /note="Predicted nucleic acid-binding protein DR0291,
                     contains C4-type Zn-ribbon domain [General function
                     prediction only]; COG1579"
                     /db_xref="CDD:441187"
     Region          901..972
                     /region_name="RRM2_RBM26_like"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     RNA-binding protein 26 (RBM26) and similar proteins;
                     cd12258"
                     /db_xref="CDD:409703"
     CDS             1..999
                     /gene="RBM26"
                     /gene_synonym="ARRS2; C13orf10; PPP1R132; PRO1777; SE70-2;
                     ZC3H17"
                     /coded_by="XM_006719857.3:482..3481"
                     /db_xref="GeneID:64062"
                     /db_xref="HGNC:HGNC:20327"
                     /db_xref="MIM:620081"
ORIGIN      
        1 mvskmiienf ealkswlskt lepicdadps alakyvlalv kkdksekelk alcidqldvf
       61 lqketqifve klfdavntks ylpppeqpss gslkveffph qekdikkeei tkeeerekkf
      121 srrlnhsppq sssryrenrs rderkkddrs rkrdydrnpp rrdsyrdryn rrrgrsrsys
      181 rsrsrswske rlrerdrdrs rtrsrsrtrs rerdlvkpky dldrtdplen nytpvssvps
      241 issghypvpt lsstitviap thhgnnttes wsefhedqvd hnsyvrppmp kkrcrdydek
      301 gfcmrgdmcp fdhgsdpvvv edvnlpgmlp fpaqppvveg ppppglpppp piltpppvnl
      361 rppvpppgpl ppslppvtdd isyslvltgp ppplpplqps gmdappnsat ssvptvvttg
      421 ihhqpppapp slftavfvlp dtydtdgynp eapsitntsr pmyrhrvhaq rpnligltsg
      481 dmdlpprekp pnkssmrivv dsesrkrtig sgepgvptkk twfdkpnfnr tnspgfqkkv
      541 qfgnentkle lrkvppelnn isklnehfsr fgtlvnlqva yngdpegali qfatyeeakk
      601 aissteavln nrfikvywhr egstqqlqtt spkvmqplvq qpilpvvkqs vkerlgpvps
      661 stiepaeaqs assdlpqnvt klsvkdrlgf vskpsvsate kvlststglt ktvynpaalk
      721 aaqktllvst savdnneaqk kkqealklqq dvrkrkqeil ekhietqkml iskleknktm
      781 ksedkaeimk tlevltknit klkdevkaas pgrclpksik tktqmqkell dteldlykkm
      841 qageevtelr rkytelqlea akrgilssgr grgihsrgrg avhgrgrgrg rgrgvpghav
      901 vdhrpralei saftesdred llphfaqyge iedcqiddss lhavitfktr aeaeaaavhg
      961 arfkgqdlkl awnkpvtnis aveteevepd eeereiiia
//
LOCUS       XP_047286465             998 aa            linear   PRI 05-AUG-2025
DEFINITION  RNA-binding protein 26 isoform X16 [Homo sapiens].
ACCESSION   XP_047286465
VERSION     XP_047286465.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430509.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..998
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..998
                     /product="RNA-binding protein 26 isoform X16"
                     /calculated_mol_wt=112557
     Region          11..76
                     /region_name="PWI"
                     /note="PWI domain; pfam01480"
                     /db_xref="CDD:460224"
     Region          <294..314
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Region          546..621
                     /region_name="RRM1_RBM26"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     RNA-binding protein 26 (RBM26); cd12516"
                     /db_xref="CDD:409938"
     Region          693..>785
                     /region_name="DR0291"
                     /note="Predicted nucleic acid-binding protein DR0291,
                     contains C4-type Zn-ribbon domain [General function
                     prediction only]; COG1579"
                     /db_xref="CDD:441187"
     Region          877..948
                     /region_name="RRM2_RBM26_like"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     RNA-binding protein 26 (RBM26) and similar proteins;
                     cd12258"
                     /db_xref="CDD:409703"
     CDS             1..998
                     /gene="RBM26"
                     /gene_synonym="ARRS2; C13orf10; PPP1R132; PRO1777; SE70-2;
                     ZC3H17"
                     /coded_by="XM_047430509.1:482..3478"
                     /db_xref="GeneID:64062"
                     /db_xref="HGNC:HGNC:20327"
                     /db_xref="MIM:620081"
ORIGIN      
        1 mvskmiienf ealkswlskt lepicdadps alakyvlalv kkdksekelk alcidqldvf
       61 lqketqifve klfdavntks ylpppeqpss gslkveffph qekdikkeei tkeeerekkf
      121 srrlnhsppq sssryrenrs rderkkddrs rkrdydrnpp rrdsyrdryn rrrgrsrsys
      181 rsrsrswske rlrerdrdrs rtrsrsrtrs rerdlvkpky dldrtdplen nytpvssvps
      241 issghypvpt lsstitviap thhgnnttes wsefhedqvd hnsyvrppmp kkrcrdydek
      301 gfcmrgdmcp fdhgsdpvvv edvnlpgmlp fpaqppvveg ppppglpppp piltpppvnl
      361 rppvpppgpl ppslppvtdd isyslvltgp ppplpplqps gmdappnsat ssvptvvttg
      421 ihhqpppapp slftavfvlp dtydtdgynp eapsitntsr pmyrhrvhaq rpnligltsg
      481 dmdlpprekp pnkssmrivv dsesrkrtig sgepgvptkk twfdkpnfnr tnspgfqkkv
      541 qfgnentkle lrkvppelnn isklnehfsr fgtlvnlqva yngdpegali qfatyeeakk
      601 aissteavln nrfikvywhr egstqqlqtt spkvmqplvq qpilpvvkqs vkerlgpvps
      661 stiepaeaqs assdlpqvls tstgltktvy npaalkaaqk tllvstsavd nneaqkkkqe
      721 alklqqdvrk rkqeilekhi etqkmliskl eknktmksed kaeimktlev ltknitklkd
      781 evkaaspgrc lpksiktktq mqkelldtel dlykkmqage evtelrrkyt elqleaakrg
      841 ilssgrgrgi hsrgrgavhg rgrgrgrgrg vpghavvdhr praleisaft esdredllph
      901 faqygeiedc qiddsslhav itfktraeae aaavhgarfk gqdlklawnk pvtnisavet
      961 eevepdeeef qeeslvddsl lqdddeeeed nesrswrr
//
LOCUS       XP_047286466             997 aa            linear   PRI 05-AUG-2025
DEFINITION  RNA-binding protein 26 isoform X17 [Homo sapiens].
ACCESSION   XP_047286466
VERSION     XP_047286466.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430510.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..997
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..997
                     /product="RNA-binding protein 26 isoform X17"
                     /calculated_mol_wt=112042
     Region          11..76
                     /region_name="PWI"
                     /note="PWI domain; pfam01480"
                     /db_xref="CDD:460224"
     Region          <294..314
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Region          546..621
                     /region_name="RRM1_RBM26"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     RNA-binding protein 26 (RBM26); cd12516"
                     /db_xref="CDD:409938"
     Region          714..>806
                     /region_name="DR0291"
                     /note="Predicted nucleic acid-binding protein DR0291,
                     contains C4-type Zn-ribbon domain [General function
                     prediction only]; COG1579"
                     /db_xref="CDD:441187"
     Region          898..969
                     /region_name="RRM2_RBM26_like"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     RNA-binding protein 26 (RBM26) and similar proteins;
                     cd12258"
                     /db_xref="CDD:409703"
     CDS             1..997
                     /gene="RBM26"
                     /gene_synonym="ARRS2; C13orf10; PPP1R132; PRO1777; SE70-2;
                     ZC3H17"
                     /coded_by="XM_047430510.1:482..3475"
                     /db_xref="GeneID:64062"
                     /db_xref="HGNC:HGNC:20327"
                     /db_xref="MIM:620081"
ORIGIN      
        1 mvskmiienf ealkswlskt lepicdadps alakyvlalv kkdksekelk alcidqldvf
       61 lqketqifve klfdavntks ylpppeqpss gslkveffph qekdikkeei tkeeerekkf
      121 srrlnhsppq sssryrenrs rderkkddrs rkrdydrnpp rrdsyrdryn rrrgrsrsys
      181 rsrsrswske rlrerdrdrs rtrsrsrtrs rerdlvkpky dldrtdplen nytpvssvps
      241 issghypvpt lsstitviap thhgnnttes wsefhedqvd hnsyvrppmp kkrcrdydek
      301 gfcmrgdmcp fdhgsdpvvv edvnlpgmlp fpaqppvveg ppppglpppp piltpppvnl
      361 rppvpppgpl ppslppvtdd isyslvltgp ppplpplqps gmdappnsat ssvptvvttg
      421 ihhqpppapp slftavfvlp dtydtdgynp eapsitntsr pmyrhrvhaq rpnligltsg
      481 dmdlpprekp pnkssmrivv dsesrkrtig sgepgvptkk twfdkpnfnr tnspgfqkkv
      541 qfgnentkle lrkvppelnn isklnehfsr fgtlvnlqva yngdpegali qfatyeeakk
      601 aissteavln nrfikvywhr egstqqlqtt spkplvqqpi lpvvkqsvke rlgpvpssti
      661 epaeaqsass dlpqnvtkls vkdrlgfvsk psvsatekvl ststgltktv ynpaalkaaq
      721 ktllvstsav dnneaqkkkq ealklqqdvr krkqeilekh ietqkmlisk leknktmkse
      781 dkaeimktle vltknitklk devkaaspgr clpksiktkt qmqkelldte ldlykkmqag
      841 eevtelrrky telqleaakr gilssgrgrg ihsrgrgavh grgrgrgrgr gvpghavvdh
      901 rpraleisaf tesdredllp hfaqygeied cqiddsslha vitfktraea eaaavhgarf
      961 kgqdlklawn kpvtnisave teevepdeee qreiiia
//
LOCUS       XP_016876185             996 aa            linear   PRI 05-AUG-2025
DEFINITION  RNA-binding protein 26 isoform X18 [Homo sapiens].
ACCESSION   XP_016876185
VERSION     XP_016876185.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020696.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..996
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..996
                     /product="RNA-binding protein 26 isoform X18"
                     /calculated_mol_wt=112224
     Region          11..76
                     /region_name="PWI"
                     /note="PWI domain; pfam01480"
                     /db_xref="CDD:460224"
     Region          <294..314
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Region          541..616
                     /region_name="RRM1_RBM26"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     RNA-binding protein 26 (RBM26); cd12516"
                     /db_xref="CDD:409938"
     Region          688..>780
                     /region_name="DR0291"
                     /note="Predicted nucleic acid-binding protein DR0291,
                     contains C4-type Zn-ribbon domain [General function
                     prediction only]; COG1579"
                     /db_xref="CDD:441187"
     Region          872..943
                     /region_name="RRM2_RBM26_like"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     RNA-binding protein 26 (RBM26) and similar proteins;
                     cd12258"
                     /db_xref="CDD:409703"
     CDS             1..996
                     /gene="RBM26"
                     /gene_synonym="ARRS2; C13orf10; PPP1R132; PRO1777; SE70-2;
                     ZC3H17"
                     /coded_by="XM_017020696.3:482..3472"
                     /db_xref="GeneID:64062"
                     /db_xref="HGNC:HGNC:20327"
                     /db_xref="MIM:620081"
ORIGIN      
        1 mvskmiienf ealkswlskt lepicdadps alakyvlalv kkdksekelk alcidqldvf
       61 lqketqifve klfdavntks ylpppeqpss gslkveffph qekdikkeei tkeeerekkf
      121 srrlnhsppq sssryrenrs rderkkddrs rkrdydrnpp rrdsyrdryn rrrgrsrsys
      181 rsrsrswske rlrerdrdrs rtrsrsrtrs rerdlvkpky dldrtdplen nytpvssvps
      241 issghypvpt lsstitviap thhgnnttes wsefhedqvd hnsyvrppmp kkrcrdydek
      301 gfcmrgdmcp fdhgsdpvvv edvnlpgmlp fpaqppvveg ppppglpppp piltpppvnl
      361 rppvpppgpl ppslppvtdd isyslvltgp ppplpplqps gmdappnsat ssvptvvttg
      421 ihhqpppapp slftadtydt dgynpeapsi tntsrpmyrh rvhaqrpnli gltsgdmdlp
      481 prekppnkss mrivvdsesr krtigsgepg vptkktwfdk pnfnrtnspg fqkkvqfgne
      541 ntklelrkvp pelnniskln ehfsrfgtlv nlqvayngdp egaliqfaty eeakkaisst
      601 eavlnnrfik vywhregstq qlqttspkvm qplvqqpilp vvkqsvkerl gpvpsstiep
      661 aeaqsassdl pqvlststgl tktvynpaal kaaqktllvs tsavdnneaq kkkqealklq
      721 qdvrkrkqei lekhietqkm liskleknkt mksedkaeim ktlevltkni tklkdevkaa
      781 spgrclpksi ktktqmqkel ldteldlykk mqageevtel rrkytelqle aakrgilssg
      841 rgrgihsrgr gavhgrgrgr grgrgvpgha vvdhrprale isaftesdre dllphfaqyg
      901 eiedcqidds slhavitfkt raeaeaaavh garfkgqdlk lawnkpvtni saveteevep
      961 deeeiiplsf hefelngeks rrapgiryfe kfeiav
//
LOCUS       XP_047286467             995 aa            linear   PRI 05-AUG-2025
DEFINITION  RNA-binding protein 26 isoform X19 [Homo sapiens].
ACCESSION   XP_047286467
VERSION     XP_047286467.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430511.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..995
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..995
                     /product="RNA-binding protein 26 isoform X19"
                     /calculated_mol_wt=111844
     Region          11..76
                     /region_name="PWI"
                     /note="PWI domain; pfam01480"
                     /db_xref="CDD:460224"
     Region          <294..314
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Region          541..616
                     /region_name="RRM1_RBM26"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     RNA-binding protein 26 (RBM26); cd12516"
                     /db_xref="CDD:409938"
     Region          712..>804
                     /region_name="DR0291"
                     /note="Predicted nucleic acid-binding protein DR0291,
                     contains C4-type Zn-ribbon domain [General function
                     prediction only]; COG1579"
                     /db_xref="CDD:441187"
     Region          896..967
                     /region_name="RRM2_RBM26_like"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     RNA-binding protein 26 (RBM26) and similar proteins;
                     cd12258"
                     /db_xref="CDD:409703"
     CDS             1..995
                     /gene="RBM26"
                     /gene_synonym="ARRS2; C13orf10; PPP1R132; PRO1777; SE70-2;
                     ZC3H17"
                     /coded_by="XM_047430511.1:482..3469"
                     /db_xref="GeneID:64062"
                     /db_xref="HGNC:HGNC:20327"
                     /db_xref="MIM:620081"
ORIGIN      
        1 mvskmiienf ealkswlskt lepicdadps alakyvlalv kkdksekelk alcidqldvf
       61 lqketqifve klfdavntks ylpppeqpss gslkveffph qekdikkeei tkeeerekkf
      121 srrlnhsppq sssryrenrs rderkkddrs rkrdydrnpp rrdsyrdryn rrrgrsrsys
      181 rsrsrswske rlrerdrdrs rtrsrsrtrs rerdlvkpky dldrtdplen nytpvssvps
      241 issghypvpt lsstitviap thhgnnttes wsefhedqvd hnsyvrppmp kkrcrdydek
      301 gfcmrgdmcp fdhgsdpvvv edvnlpgmlp fpaqppvveg ppppglpppp piltpppvnl
      361 rppvpppgpl ppslppvtdd isyslvltgp ppplpplqps gmdappnsat ssvptvvttg
      421 ihhqpppapp slftadtydt dgynpeapsi tntsrpmyrh rvhaqrpnli gltsgdmdlp
      481 prekppnkss mrivvdsesr krtigsgepg vptkktwfdk pnfnrtnspg fqkkvqfgne
      541 ntklelrkvp pelnniskln ehfsrfgtlv nlqvayngdp egaliqfaty eeakkaisst
      601 eavlnnrfik vywhregstq qlqttspkvm qplvqqpilp vvkqsvkerl gpvpsstiep
      661 aeaqsassdl pqnvtklsvk drlgfvskps vsatekvlst stgltktvyn paalkaaqkt
      721 llvstsavdn neaqkkkqea lklqqdvrkr kqeilekhie tqkmliskle knktmksedk
      781 aeimktlevl tknitklkde vkaaspgrcl pksiktktqm qkelldteld lykkmqagee
      841 vtelrrkyte lqleaakrgi lssgrgrgih srgrgavhgr grgrgrgrgv pghavvdhrp
      901 raleisafte sdredllphf aqygeiedcq iddsslhavi tfktraeaea aavhgarfkg
      961 qdlklawnkp vtnisavete evepdeeeqr eiiia
//
LOCUS       XP_047286468             995 aa            linear   PRI 05-AUG-2025
DEFINITION  RNA-binding protein 26 isoform X20 [Homo sapiens].
ACCESSION   XP_047286468
VERSION     XP_047286468.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430512.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..995
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..995
                     /product="RNA-binding protein 26 isoform X20"
                     /calculated_mol_wt=112198
     Region          11..76
                     /region_name="PWI"
                     /note="PWI domain; pfam01480"
                     /db_xref="CDD:460224"
     Region          <294..314
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Region          546..621
                     /region_name="RRM1_RBM26"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     RNA-binding protein 26 (RBM26); cd12516"
                     /db_xref="CDD:409938"
     Region          690..>782
                     /region_name="DR0291"
                     /note="Predicted nucleic acid-binding protein DR0291,
                     contains C4-type Zn-ribbon domain [General function
                     prediction only]; COG1579"
                     /db_xref="CDD:441187"
     Region          874..945
                     /region_name="RRM2_RBM26_like"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     RNA-binding protein 26 (RBM26) and similar proteins;
                     cd12258"
                     /db_xref="CDD:409703"
     CDS             1..995
                     /gene="RBM26"
                     /gene_synonym="ARRS2; C13orf10; PPP1R132; PRO1777; SE70-2;
                     ZC3H17"
                     /coded_by="XM_047430512.1:482..3469"
                     /db_xref="GeneID:64062"
                     /db_xref="HGNC:HGNC:20327"
                     /db_xref="MIM:620081"
ORIGIN      
        1 mvskmiienf ealkswlskt lepicdadps alakyvlalv kkdksekelk alcidqldvf
       61 lqketqifve klfdavntks ylpppeqpss gslkveffph qekdikkeei tkeeerekkf
      121 srrlnhsppq sssryrenrs rderkkddrs rkrdydrnpp rrdsyrdryn rrrgrsrsys
      181 rsrsrswske rlrerdrdrs rtrsrsrtrs rerdlvkpky dldrtdplen nytpvssvps
      241 issghypvpt lsstitviap thhgnnttes wsefhedqvd hnsyvrppmp kkrcrdydek
      301 gfcmrgdmcp fdhgsdpvvv edvnlpgmlp fpaqppvveg ppppglpppp piltpppvnl
      361 rppvpppgpl ppslppvtdd isyslvltgp ppplpplqps gmdappnsat ssvptvvttg
      421 ihhqpppapp slftavfvlp dtydtdgynp eapsitntsr pmyrhrvhaq rpnligltsg
      481 dmdlpprekp pnkssmrivv dsesrkrtig sgepgvptkk twfdkpnfnr tnspgfqkkv
      541 qfgnentkle lrkvppelnn isklnehfsr fgtlvnlqva yngdpegali qfatyeeakk
      601 aissteavln nrfikvywhr egstqqlqtt spkplvqqpi lpvvkqsvke rlgpvpssti
      661 epaeaqsass dlpqvlstst gltktvynpa alkaaqktll vstsavdnne aqkkkqealk
      721 lqqdvrkrkq eilekhietq kmlisklekn ktmksedkae imktlevltk nitklkdevk
      781 aaspgrclpk siktktqmqk elldteldly kkmqageevt elrrkytelq leaakrgils
      841 sgrgrgihsr grgavhgrgr grgrgrgvpg havvdhrpra leisaftesd redllphfaq
      901 ygeiedcqid dsslhavitf ktraeaeaaa vhgarfkgqd lklawnkpvt nisaveteev
      961 epdeeefqee slvddsllqd ddeeeednes rswrr
//
LOCUS       XP_016876186             994 aa            linear   PRI 05-AUG-2025
DEFINITION  RNA-binding protein 26 isoform X21 [Homo sapiens].
ACCESSION   XP_016876186
VERSION     XP_016876186.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020697.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..994
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..994
                     /product="RNA-binding protein 26 isoform X21"
                     /calculated_mol_wt=111716
     Region          11..76
                     /region_name="PWI"
                     /note="PWI domain; pfam01480"
                     /db_xref="CDD:460224"
     Region          <294..314
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Region          541..616
                     /region_name="RRM1_RBM26"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     RNA-binding protein 26 (RBM26); cd12516"
                     /db_xref="CDD:409938"
     Region          712..>804
                     /region_name="DR0291"
                     /note="Predicted nucleic acid-binding protein DR0291,
                     contains C4-type Zn-ribbon domain [General function
                     prediction only]; COG1579"
                     /db_xref="CDD:441187"
     Region          896..967
                     /region_name="RRM2_RBM26_like"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     RNA-binding protein 26 (RBM26) and similar proteins;
                     cd12258"
                     /db_xref="CDD:409703"
     CDS             1..994
                     /gene="RBM26"
                     /gene_synonym="ARRS2; C13orf10; PPP1R132; PRO1777; SE70-2;
                     ZC3H17"
                     /coded_by="XM_017020697.3:482..3466"
                     /db_xref="GeneID:64062"
                     /db_xref="HGNC:HGNC:20327"
                     /db_xref="MIM:620081"
ORIGIN      
        1 mvskmiienf ealkswlskt lepicdadps alakyvlalv kkdksekelk alcidqldvf
       61 lqketqifve klfdavntks ylpppeqpss gslkveffph qekdikkeei tkeeerekkf
      121 srrlnhsppq sssryrenrs rderkkddrs rkrdydrnpp rrdsyrdryn rrrgrsrsys
      181 rsrsrswske rlrerdrdrs rtrsrsrtrs rerdlvkpky dldrtdplen nytpvssvps
      241 issghypvpt lsstitviap thhgnnttes wsefhedqvd hnsyvrppmp kkrcrdydek
      301 gfcmrgdmcp fdhgsdpvvv edvnlpgmlp fpaqppvveg ppppglpppp piltpppvnl
      361 rppvpppgpl ppslppvtdd isyslvltgp ppplpplqps gmdappnsat ssvptvvttg
      421 ihhqpppapp slftadtydt dgynpeapsi tntsrpmyrh rvhaqrpnli gltsgdmdlp
      481 prekppnkss mrivvdsesr krtigsgepg vptkktwfdk pnfnrtnspg fqkkvqfgne
      541 ntklelrkvp pelnniskln ehfsrfgtlv nlqvayngdp egaliqfaty eeakkaisst
      601 eavlnnrfik vywhregstq qlqttspkvm qplvqqpilp vvkqsvkerl gpvpsstiep
      661 aeaqsassdl pqnvtklsvk drlgfvskps vsatekvlst stgltktvyn paalkaaqkt
      721 llvstsavdn neaqkkkqea lklqqdvrkr kqeilekhie tqkmliskle knktmksedk
      781 aeimktlevl tknitklkde vkaaspgrcl pksiktktqm qkelldteld lykkmqagee
      841 vtelrrkyte lqleaakrgi lssgrgrgih srgrgavhgr grgrgrgrgv pghavvdhrp
      901 raleisafte sdredllphf aqygeiedcq iddsslhavi tfktraeaea aavhgarfkg
      961 qdlklawnkp vtnisavete evepdeeere iiia
//
LOCUS       XP_047286469             993 aa            linear   PRI 05-AUG-2025
DEFINITION  RNA-binding protein 26 isoform X22 [Homo sapiens].
ACCESSION   XP_047286469
VERSION     XP_047286469.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430513.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..993
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..993
                     /product="RNA-binding protein 26 isoform X22"
                     /calculated_mol_wt=112001
     Region          11..76
                     /region_name="PWI"
                     /note="PWI domain; pfam01480"
                     /db_xref="CDD:460224"
     Region          <294..314
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Region          541..616
                     /region_name="RRM1_RBM26"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     RNA-binding protein 26 (RBM26); cd12516"
                     /db_xref="CDD:409938"
     Region          688..>780
                     /region_name="DR0291"
                     /note="Predicted nucleic acid-binding protein DR0291,
                     contains C4-type Zn-ribbon domain [General function
                     prediction only]; COG1579"
                     /db_xref="CDD:441187"
     Region          872..943
                     /region_name="RRM2_RBM26_like"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     RNA-binding protein 26 (RBM26) and similar proteins;
                     cd12258"
                     /db_xref="CDD:409703"
     CDS             1..993
                     /gene="RBM26"
                     /gene_synonym="ARRS2; C13orf10; PPP1R132; PRO1777; SE70-2;
                     ZC3H17"
                     /coded_by="XM_047430513.1:482..3463"
                     /db_xref="GeneID:64062"
                     /db_xref="HGNC:HGNC:20327"
                     /db_xref="MIM:620081"
ORIGIN      
        1 mvskmiienf ealkswlskt lepicdadps alakyvlalv kkdksekelk alcidqldvf
       61 lqketqifve klfdavntks ylpppeqpss gslkveffph qekdikkeei tkeeerekkf
      121 srrlnhsppq sssryrenrs rderkkddrs rkrdydrnpp rrdsyrdryn rrrgrsrsys
      181 rsrsrswske rlrerdrdrs rtrsrsrtrs rerdlvkpky dldrtdplen nytpvssvps
      241 issghypvpt lsstitviap thhgnnttes wsefhedqvd hnsyvrppmp kkrcrdydek
      301 gfcmrgdmcp fdhgsdpvvv edvnlpgmlp fpaqppvveg ppppglpppp piltpppvnl
      361 rppvpppgpl ppslppvtdd isyslvltgp ppplpplqps gmdappnsat ssvptvvttg
      421 ihhqpppapp slftadtydt dgynpeapsi tntsrpmyrh rvhaqrpnli gltsgdmdlp
      481 prekppnkss mrivvdsesr krtigsgepg vptkktwfdk pnfnrtnspg fqkkvqfgne
      541 ntklelrkvp pelnniskln ehfsrfgtlv nlqvayngdp egaliqfaty eeakkaisst
      601 eavlnnrfik vywhregstq qlqttspkvm qplvqqpilp vvkqsvkerl gpvpsstiep
      661 aeaqsassdl pqvlststgl tktvynpaal kaaqktllvs tsavdnneaq kkkqealklq
      721 qdvrkrkqei lekhietqkm liskleknkt mksedkaeim ktlevltkni tklkdevkaa
      781 spgrclpksi ktktqmqkel ldteldlykk mqageevtel rrkytelqle aakrgilssg
      841 rgrgihsrgr gavhgrgrgr grgrgvpgha vvdhrprale isaftesdre dllphfaqyg
      901 eiedcqidds slhavitfkt raeaeaaavh garfkgqdlk lawnkpvtni saveteevep
      961 deeefqeesl vddsllqddd eeeednesrs wrr
//
LOCUS       XP_016876184             993 aa            linear   PRI 05-AUG-2025
DEFINITION  RNA-binding protein 26 isoform X23 [Homo sapiens].
ACCESSION   XP_016876184
VERSION     XP_016876184.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020695.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..993
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..993
                     /product="RNA-binding protein 26 isoform X23"
                     /calculated_mol_wt=111865
     Region          11..76
                     /region_name="PWI"
                     /note="PWI domain; pfam01480"
                     /db_xref="CDD:460224"
     Region          <294..314
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Region          541..616
                     /region_name="RRM1_RBM26"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     RNA-binding protein 26 (RBM26); cd12516"
                     /db_xref="CDD:409938"
     Region          685..>777
                     /region_name="DR0291"
                     /note="Predicted nucleic acid-binding protein DR0291,
                     contains C4-type Zn-ribbon domain [General function
                     prediction only]; COG1579"
                     /db_xref="CDD:441187"
     Region          869..940
                     /region_name="RRM2_RBM26_like"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     RNA-binding protein 26 (RBM26) and similar proteins;
                     cd12258"
                     /db_xref="CDD:409703"
     CDS             1..993
                     /gene="RBM26"
                     /gene_synonym="ARRS2; C13orf10; PPP1R132; PRO1777; SE70-2;
                     ZC3H17"
                     /coded_by="XM_017020695.3:482..3463"
                     /db_xref="GeneID:64062"
                     /db_xref="HGNC:HGNC:20327"
                     /db_xref="MIM:620081"
ORIGIN      
        1 mvskmiienf ealkswlskt lepicdadps alakyvlalv kkdksekelk alcidqldvf
       61 lqketqifve klfdavntks ylpppeqpss gslkveffph qekdikkeei tkeeerekkf
      121 srrlnhsppq sssryrenrs rderkkddrs rkrdydrnpp rrdsyrdryn rrrgrsrsys
      181 rsrsrswske rlrerdrdrs rtrsrsrtrs rerdlvkpky dldrtdplen nytpvssvps
      241 issghypvpt lsstitviap thhgnnttes wsefhedqvd hnsyvrppmp kkrcrdydek
      301 gfcmrgdmcp fdhgsdpvvv edvnlpgmlp fpaqppvveg ppppglpppp piltpppvnl
      361 rppvpppgpl ppslppvtdd isyslvltgp ppplpplqps gmdappnsat ssvptvvttg
      421 ihhqpppapp slftadtydt dgynpeapsi tntsrpmyrh rvhaqrpnli gltsgdmdlp
      481 prekppnkss mrivvdsesr krtigsgepg vptkktwfdk pnfnrtnspg fqkkvqfgne
      541 ntklelrkvp pelnniskln ehfsrfgtlv nlqvayngdp egaliqfaty eeakkaisst
      601 eavlnnrfik vywhregstq qlqttspkpl vqqpilpvvk qsvkerlgpv psstiepaea
      661 qsassdlpqv lststgltkt vynpaalkaa qktllvstsa vdnneaqkkk qealklqqdv
      721 rkrkqeilek hietqkmlis kleknktmks edkaeimktl evltknitkl kdevkaaspg
      781 rclpksiktk tqmqkelldt eldlykkmqa geevtelrrk ytelqleaak rgilssgrgr
      841 gihsrgrgav hgrgrgrgrg rgvpghavvd hrpraleisa ftesdredll phfaqygeie
      901 dcqiddsslh avitfktrae aeaaavhgar fkgqdlklaw nkpvtnisav eteevepdee
      961 eiiplsfhef elngeksrra pgiryfekfe iav
//
LOCUS       XP_047286470             992 aa            linear   PRI 05-AUG-2025
DEFINITION  RNA-binding protein 26 isoform X24 [Homo sapiens].
ACCESSION   XP_047286470
VERSION     XP_047286470.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430514.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..992
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..992
                     /product="RNA-binding protein 26 isoform X24"
                     /calculated_mol_wt=111486
     Region          11..76
                     /region_name="PWI"
                     /note="PWI domain; pfam01480"
                     /db_xref="CDD:460224"
     Region          <294..314
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Region          541..616
                     /region_name="RRM1_RBM26"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     RNA-binding protein 26 (RBM26); cd12516"
                     /db_xref="CDD:409938"
     Region          709..>801
                     /region_name="DR0291"
                     /note="Predicted nucleic acid-binding protein DR0291,
                     contains C4-type Zn-ribbon domain [General function
                     prediction only]; COG1579"
                     /db_xref="CDD:441187"
     Region          893..964
                     /region_name="RRM2_RBM26_like"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     RNA-binding protein 26 (RBM26) and similar proteins;
                     cd12258"
                     /db_xref="CDD:409703"
     CDS             1..992
                     /gene="RBM26"
                     /gene_synonym="ARRS2; C13orf10; PPP1R132; PRO1777; SE70-2;
                     ZC3H17"
                     /coded_by="XM_047430514.1:482..3460"
                     /db_xref="GeneID:64062"
                     /db_xref="HGNC:HGNC:20327"
                     /db_xref="MIM:620081"
ORIGIN      
        1 mvskmiienf ealkswlskt lepicdadps alakyvlalv kkdksekelk alcidqldvf
       61 lqketqifve klfdavntks ylpppeqpss gslkveffph qekdikkeei tkeeerekkf
      121 srrlnhsppq sssryrenrs rderkkddrs rkrdydrnpp rrdsyrdryn rrrgrsrsys
      181 rsrsrswske rlrerdrdrs rtrsrsrtrs rerdlvkpky dldrtdplen nytpvssvps
      241 issghypvpt lsstitviap thhgnnttes wsefhedqvd hnsyvrppmp kkrcrdydek
      301 gfcmrgdmcp fdhgsdpvvv edvnlpgmlp fpaqppvveg ppppglpppp piltpppvnl
      361 rppvpppgpl ppslppvtdd isyslvltgp ppplpplqps gmdappnsat ssvptvvttg
      421 ihhqpppapp slftadtydt dgynpeapsi tntsrpmyrh rvhaqrpnli gltsgdmdlp
      481 prekppnkss mrivvdsesr krtigsgepg vptkktwfdk pnfnrtnspg fqkkvqfgne
      541 ntklelrkvp pelnniskln ehfsrfgtlv nlqvayngdp egaliqfaty eeakkaisst
      601 eavlnnrfik vywhregstq qlqttspkpl vqqpilpvvk qsvkerlgpv psstiepaea
      661 qsassdlpqn vtklsvkdrl gfvskpsvsa tekvlststg ltktvynpaa lkaaqktllv
      721 stsavdnnea qkkkqealkl qqdvrkrkqe ilekhietqk mliskleknk tmksedkaei
      781 mktlevltkn itklkdevka aspgrclpks iktktqmqke lldteldlyk kmqageevte
      841 lrrkytelql eaakrgilss grgrgihsrg rgavhgrgrg rgrgrgvpgh avvdhrpral
      901 eisaftesdr edllphfaqy geiedcqidd sslhavitfk traeaeaaav hgarfkgqdl
      961 klawnkpvtn isaveteeve pdeeeqreii ia
//
LOCUS       XP_047286471             990 aa            linear   PRI 05-AUG-2025
DEFINITION  RNA-binding protein 26 isoform X25 [Homo sapiens].
ACCESSION   XP_047286471
VERSION     XP_047286471.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430515.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..990
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..990
                     /product="RNA-binding protein 26 isoform X25"
                     /calculated_mol_wt=111642
     Region          11..76
                     /region_name="PWI"
                     /note="PWI domain; pfam01480"
                     /db_xref="CDD:460224"
     Region          <294..314
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Region          541..616
                     /region_name="RRM1_RBM26"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     RNA-binding protein 26 (RBM26); cd12516"
                     /db_xref="CDD:409938"
     Region          685..>777
                     /region_name="DR0291"
                     /note="Predicted nucleic acid-binding protein DR0291,
                     contains C4-type Zn-ribbon domain [General function
                     prediction only]; COG1579"
                     /db_xref="CDD:441187"
     Region          869..940
                     /region_name="RRM2_RBM26_like"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     RNA-binding protein 26 (RBM26) and similar proteins;
                     cd12258"
                     /db_xref="CDD:409703"
     CDS             1..990
                     /gene="RBM26"
                     /gene_synonym="ARRS2; C13orf10; PPP1R132; PRO1777; SE70-2;
                     ZC3H17"
                     /coded_by="XM_047430515.1:482..3454"
                     /db_xref="GeneID:64062"
                     /db_xref="HGNC:HGNC:20327"
                     /db_xref="MIM:620081"
ORIGIN      
        1 mvskmiienf ealkswlskt lepicdadps alakyvlalv kkdksekelk alcidqldvf
       61 lqketqifve klfdavntks ylpppeqpss gslkveffph qekdikkeei tkeeerekkf
      121 srrlnhsppq sssryrenrs rderkkddrs rkrdydrnpp rrdsyrdryn rrrgrsrsys
      181 rsrsrswske rlrerdrdrs rtrsrsrtrs rerdlvkpky dldrtdplen nytpvssvps
      241 issghypvpt lsstitviap thhgnnttes wsefhedqvd hnsyvrppmp kkrcrdydek
      301 gfcmrgdmcp fdhgsdpvvv edvnlpgmlp fpaqppvveg ppppglpppp piltpppvnl
      361 rppvpppgpl ppslppvtdd isyslvltgp ppplpplqps gmdappnsat ssvptvvttg
      421 ihhqpppapp slftadtydt dgynpeapsi tntsrpmyrh rvhaqrpnli gltsgdmdlp
      481 prekppnkss mrivvdsesr krtigsgepg vptkktwfdk pnfnrtnspg fqkkvqfgne
      541 ntklelrkvp pelnniskln ehfsrfgtlv nlqvayngdp egaliqfaty eeakkaisst
      601 eavlnnrfik vywhregstq qlqttspkpl vqqpilpvvk qsvkerlgpv psstiepaea
      661 qsassdlpqv lststgltkt vynpaalkaa qktllvstsa vdnneaqkkk qealklqqdv
      721 rkrkqeilek hietqkmlis kleknktmks edkaeimktl evltknitkl kdevkaaspg
      781 rclpksiktk tqmqkelldt eldlykkmqa geevtelrrk ytelqleaak rgilssgrgr
      841 gihsrgrgav hgrgrgrgrg rgvpghavvd hrpraleisa ftesdredll phfaqygeie
      901 dcqiddsslh avitfktrae aeaaavhgar fkgqdlklaw nkpvtnisav eteevepdee
      961 efqeeslvdd sllqdddeee ednesrswrr
//
LOCUS       XP_047286472             989 aa            linear   PRI 05-AUG-2025
DEFINITION  RNA-binding protein 26 isoform X26 [Homo sapiens].
ACCESSION   XP_047286472
VERSION     XP_047286472.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430516.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..989
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..989
                     /product="RNA-binding protein 26 isoform X26"
                     /calculated_mol_wt=111165
     Region          11..76
                     /region_name="PWI"
                     /note="PWI domain; pfam01480"
                     /db_xref="CDD:460224"
     Region          <294..314
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Region          536..611
                     /region_name="RRM1_RBM26"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     RNA-binding protein 26 (RBM26); cd12516"
                     /db_xref="CDD:409938"
     Region          707..>799
                     /region_name="DR0291"
                     /note="Predicted nucleic acid-binding protein DR0291,
                     contains C4-type Zn-ribbon domain [General function
                     prediction only]; COG1579"
                     /db_xref="CDD:441187"
     Region          891..962
                     /region_name="RRM2_RBM26_like"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     RNA-binding protein 26 (RBM26) and similar proteins;
                     cd12258"
                     /db_xref="CDD:409703"
     CDS             1..989
                     /gene="RBM26"
                     /gene_synonym="ARRS2; C13orf10; PPP1R132; PRO1777; SE70-2;
                     ZC3H17"
                     /coded_by="XM_047430516.1:482..3451"
                     /db_xref="GeneID:64062"
                     /db_xref="HGNC:HGNC:20327"
                     /db_xref="MIM:620081"
ORIGIN      
        1 mvskmiienf ealkswlskt lepicdadps alakyvlalv kkdksekelk alcidqldvf
       61 lqketqifve klfdavntks ylpppeqpss gslkveffph qekdikkeei tkeeerekkf
      121 srrlnhsppq sssryrenrs rderkkddrs rkrdydrnpp rrdsyrdryn rrrgrsrsys
      181 rsrsrswske rlrerdrdrs rtrsrsrtrs rerdlvkpky dldrtdplen nytpvssvps
      241 issghypvpt lsstitviap thhgnnttes wsefhedqvd hnsyvrppmp kkrcrdydek
      301 gfcmrgdmcp fdhgsdpvvv edvnlpgmlp fpaqppvveg ppppglpppp piltpppvnl
      361 rppvpppgpl ppslppvtgp ppplpplqps gmdappnsat ssvptvvttg ihhqpppapp
      421 slftavfvlp dtydtdgynp eapsitntsr pmyrhrvhaq rpnligltsg dmdlpprekp
      481 pnkssmrivv dsesrkrtig sgepgvptkk twfdkpnfnr tnspgfqkkv qfgnentkle
      541 lrkvppelnn isklnehfsr fgtlvnlqva yngdpegali qfatyeeakk aissteavln
      601 nrfikvywhr egstqqlqtt spkvmqplvq qpilpvvkqs vkerlgpvps stiepaeaqs
      661 assdlpqnvt klsvkdrlgf vskpsvsate kvlststglt ktvynpaalk aaqktllvst
      721 savdnneaqk kkqealklqq dvrkrkqeil ekhietqkml iskleknktm ksedkaeimk
      781 tlevltknit klkdevkaas pgrclpksik tktqmqkell dteldlykkm qageevtelr
      841 rkytelqlea akrgilssgr grgihsrgrg avhgrgrgrg rgrgvpghav vdhrpralei
      901 saftesdred llphfaqyge iedcqiddss lhavitfktr aeaeaaavhg arfkgqdlkl
      961 awnkpvtnis aveteevepd eeereiiia
//
LOCUS       XP_047286473             988 aa            linear   PRI 05-AUG-2025
DEFINITION  RNA-binding protein 26 isoform X27 [Homo sapiens].
ACCESSION   XP_047286473
VERSION     XP_047286473.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430517.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..988
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..988
                     /product="RNA-binding protein 26 isoform X27"
                     /calculated_mol_wt=111449
     Region          11..76
                     /region_name="PWI"
                     /note="PWI domain; pfam01480"
                     /db_xref="CDD:460224"
     Region          <294..314
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Region          536..611
                     /region_name="RRM1_RBM26"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     RNA-binding protein 26 (RBM26); cd12516"
                     /db_xref="CDD:409938"
     Region          683..>775
                     /region_name="DR0291"
                     /note="Predicted nucleic acid-binding protein DR0291,
                     contains C4-type Zn-ribbon domain [General function
                     prediction only]; COG1579"
                     /db_xref="CDD:441187"
     Region          867..938
                     /region_name="RRM2_RBM26_like"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     RNA-binding protein 26 (RBM26) and similar proteins;
                     cd12258"
                     /db_xref="CDD:409703"
     CDS             1..988
                     /gene="RBM26"
                     /gene_synonym="ARRS2; C13orf10; PPP1R132; PRO1777; SE70-2;
                     ZC3H17"
                     /coded_by="XM_047430517.1:482..3448"
                     /db_xref="GeneID:64062"
                     /db_xref="HGNC:HGNC:20327"
                     /db_xref="MIM:620081"
ORIGIN      
        1 mvskmiienf ealkswlskt lepicdadps alakyvlalv kkdksekelk alcidqldvf
       61 lqketqifve klfdavntks ylpppeqpss gslkveffph qekdikkeei tkeeerekkf
      121 srrlnhsppq sssryrenrs rderkkddrs rkrdydrnpp rrdsyrdryn rrrgrsrsys
      181 rsrsrswske rlrerdrdrs rtrsrsrtrs rerdlvkpky dldrtdplen nytpvssvps
      241 issghypvpt lsstitviap thhgnnttes wsefhedqvd hnsyvrppmp kkrcrdydek
      301 gfcmrgdmcp fdhgsdpvvv edvnlpgmlp fpaqppvveg ppppglpppp piltpppvnl
      361 rppvpppgpl ppslppvtgp ppplpplqps gmdappnsat ssvptvvttg ihhqpppapp
      421 slftavfvlp dtydtdgynp eapsitntsr pmyrhrvhaq rpnligltsg dmdlpprekp
      481 pnkssmrivv dsesrkrtig sgepgvptkk twfdkpnfnr tnspgfqkkv qfgnentkle
      541 lrkvppelnn isklnehfsr fgtlvnlqva yngdpegali qfatyeeakk aissteavln
      601 nrfikvywhr egstqqlqtt spkvmqplvq qpilpvvkqs vkerlgpvps stiepaeaqs
      661 assdlpqvls tstgltktvy npaalkaaqk tllvstsavd nneaqkkkqe alklqqdvrk
      721 rkqeilekhi etqkmliskl eknktmksed kaeimktlev ltknitklkd evkaaspgrc
      781 lpksiktktq mqkelldtel dlykkmqage evtelrrkyt elqleaakrg ilssgrgrgi
      841 hsrgrgavhg rgrgrgrgrg vpghavvdhr praleisaft esdredllph faqygeiedc
      901 qiddsslhav itfktraeae aaavhgarfk gqdlklawnk pvtnisavet eevepdeeef
      961 qeeslvddsl lqdddeeeed nesrswrr
//
LOCUS       XP_047286474             985 aa            linear   PRI 05-AUG-2025
DEFINITION  RNA-binding protein 26 isoform X28 [Homo sapiens].
ACCESSION   XP_047286474
VERSION     XP_047286474.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430518.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..985
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..985
                     /product="RNA-binding protein 26 isoform X28"
                     /calculated_mol_wt=111091
     Region          11..76
                     /region_name="PWI"
                     /note="PWI domain; pfam01480"
                     /db_xref="CDD:460224"
     Region          <294..314
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Region          536..611
                     /region_name="RRM1_RBM26"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     RNA-binding protein 26 (RBM26); cd12516"
                     /db_xref="CDD:409938"
     Region          680..>772
                     /region_name="DR0291"
                     /note="Predicted nucleic acid-binding protein DR0291,
                     contains C4-type Zn-ribbon domain [General function
                     prediction only]; COG1579"
                     /db_xref="CDD:441187"
     Region          864..935
                     /region_name="RRM2_RBM26_like"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     RNA-binding protein 26 (RBM26) and similar proteins;
                     cd12258"
                     /db_xref="CDD:409703"
     CDS             1..985
                     /gene="RBM26"
                     /gene_synonym="ARRS2; C13orf10; PPP1R132; PRO1777; SE70-2;
                     ZC3H17"
                     /coded_by="XM_047430518.1:482..3439"
                     /db_xref="GeneID:64062"
                     /db_xref="HGNC:HGNC:20327"
                     /db_xref="MIM:620081"
ORIGIN      
        1 mvskmiienf ealkswlskt lepicdadps alakyvlalv kkdksekelk alcidqldvf
       61 lqketqifve klfdavntks ylpppeqpss gslkveffph qekdikkeei tkeeerekkf
      121 srrlnhsppq sssryrenrs rderkkddrs rkrdydrnpp rrdsyrdryn rrrgrsrsys
      181 rsrsrswske rlrerdrdrs rtrsrsrtrs rerdlvkpky dldrtdplen nytpvssvps
      241 issghypvpt lsstitviap thhgnnttes wsefhedqvd hnsyvrppmp kkrcrdydek
      301 gfcmrgdmcp fdhgsdpvvv edvnlpgmlp fpaqppvveg ppppglpppp piltpppvnl
      361 rppvpppgpl ppslppvtgp ppplpplqps gmdappnsat ssvptvvttg ihhqpppapp
      421 slftavfvlp dtydtdgynp eapsitntsr pmyrhrvhaq rpnligltsg dmdlpprekp
      481 pnkssmrivv dsesrkrtig sgepgvptkk twfdkpnfnr tnspgfqkkv qfgnentkle
      541 lrkvppelnn isklnehfsr fgtlvnlqva yngdpegali qfatyeeakk aissteavln
      601 nrfikvywhr egstqqlqtt spkplvqqpi lpvvkqsvke rlgpvpssti epaeaqsass
      661 dlpqvlstst gltktvynpa alkaaqktll vstsavdnne aqkkkqealk lqqdvrkrkq
      721 eilekhietq kmlisklekn ktmksedkae imktlevltk nitklkdevk aaspgrclpk
      781 siktktqmqk elldteldly kkmqageevt elrrkytelq leaakrgils sgrgrgihsr
      841 grgavhgrgr grgrgrgvpg havvdhrpra leisaftesd redllphfaq ygeiedcqid
      901 dsslhavitf ktraeaeaaa vhgarfkgqd lklawnkpvt nisaveteev epdeeefqee
      961 slvddsllqd ddeeeednes rswrr
//
LOCUS       XP_047286475             985 aa            linear   PRI 05-AUG-2025
DEFINITION  RNA-binding protein 26 isoform X29 [Homo sapiens].
ACCESSION   XP_047286475
VERSION     XP_047286475.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430519.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..985
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..985
                     /product="RNA-binding protein 26 isoform X29"
                     /calculated_mol_wt=110737
     Region          11..76
                     /region_name="PWI"
                     /note="PWI domain; pfam01480"
                     /db_xref="CDD:460224"
     Region          <294..314
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Region          531..606
                     /region_name="RRM1_RBM26"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     RNA-binding protein 26 (RBM26); cd12516"
                     /db_xref="CDD:409938"
     Region          702..>794
                     /region_name="DR0291"
                     /note="Predicted nucleic acid-binding protein DR0291,
                     contains C4-type Zn-ribbon domain [General function
                     prediction only]; COG1579"
                     /db_xref="CDD:441187"
     Region          886..957
                     /region_name="RRM2_RBM26_like"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     RNA-binding protein 26 (RBM26) and similar proteins;
                     cd12258"
                     /db_xref="CDD:409703"
     CDS             1..985
                     /gene="RBM26"
                     /gene_synonym="ARRS2; C13orf10; PPP1R132; PRO1777; SE70-2;
                     ZC3H17"
                     /coded_by="XM_047430519.1:482..3439"
                     /db_xref="GeneID:64062"
                     /db_xref="HGNC:HGNC:20327"
                     /db_xref="MIM:620081"
ORIGIN      
        1 mvskmiienf ealkswlskt lepicdadps alakyvlalv kkdksekelk alcidqldvf
       61 lqketqifve klfdavntks ylpppeqpss gslkveffph qekdikkeei tkeeerekkf
      121 srrlnhsppq sssryrenrs rderkkddrs rkrdydrnpp rrdsyrdryn rrrgrsrsys
      181 rsrsrswske rlrerdrdrs rtrsrsrtrs rerdlvkpky dldrtdplen nytpvssvps
      241 issghypvpt lsstitviap thhgnnttes wsefhedqvd hnsyvrppmp kkrcrdydek
      301 gfcmrgdmcp fdhgsdpvvv edvnlpgmlp fpaqppvveg ppppglpppp piltpppvnl
      361 rppvpppgpl ppslppvtgp ppplpplqps gmdappnsat ssvptvvttg ihhqpppapp
      421 slftadtydt dgynpeapsi tntsrpmyrh rvhaqrpnli gltsgdmdlp prekppnkss
      481 mrivvdsesr krtigsgepg vptkktwfdk pnfnrtnspg fqkkvqfgne ntklelrkvp
      541 pelnniskln ehfsrfgtlv nlqvayngdp egaliqfaty eeakkaisst eavlnnrfik
      601 vywhregstq qlqttspkvm qplvqqpilp vvkqsvkerl gpvpsstiep aeaqsassdl
      661 pqnvtklsvk drlgfvskps vsatekvlst stgltktvyn paalkaaqkt llvstsavdn
      721 neaqkkkqea lklqqdvrkr kqeilekhie tqkmliskle knktmksedk aeimktlevl
      781 tknitklkde vkaaspgrcl pksiktktqm qkelldteld lykkmqagee vtelrrkyte
      841 lqleaakrgi lssgrgrgih srgrgavhgr grgrgrgrgv pghavvdhrp raleisafte
      901 sdredllphf aqygeiedcq iddsslhavi tfktraeaea aavhgarfkg qdlklawnkp
      961 vtnisavete evepdeeeqr eiiia
//
LOCUS       XP_047286477             981 aa            linear   PRI 05-AUG-2025
DEFINITION  RNA-binding protein 26 isoform X30 [Homo sapiens].
ACCESSION   XP_047286477
VERSION     XP_047286477.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430521.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..981
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..981
                     /product="RNA-binding protein 26 isoform X30"
                     /calculated_mol_wt=110250
     Region          11..76
                     /region_name="PWI"
                     /note="PWI domain; pfam01480"
                     /db_xref="CDD:460224"
     Region          <294..314
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Region          531..606
                     /region_name="RRM1_RBM26"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     RNA-binding protein 26 (RBM26); cd12516"
                     /db_xref="CDD:409938"
     Region          699..>791
                     /region_name="DR0291"
                     /note="Predicted nucleic acid-binding protein DR0291,
                     contains C4-type Zn-ribbon domain [General function
                     prediction only]; COG1579"
                     /db_xref="CDD:441187"
     Region          883..954
                     /region_name="RRM2_RBM26_like"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     RNA-binding protein 26 (RBM26) and similar proteins;
                     cd12258"
                     /db_xref="CDD:409703"
     CDS             1..981
                     /gene="RBM26"
                     /gene_synonym="ARRS2; C13orf10; PPP1R132; PRO1777; SE70-2;
                     ZC3H17"
                     /coded_by="XM_047430521.1:482..3427"
                     /db_xref="GeneID:64062"
                     /db_xref="HGNC:HGNC:20327"
                     /db_xref="MIM:620081"
ORIGIN      
        1 mvskmiienf ealkswlskt lepicdadps alakyvlalv kkdksekelk alcidqldvf
       61 lqketqifve klfdavntks ylpppeqpss gslkveffph qekdikkeei tkeeerekkf
      121 srrlnhsppq sssryrenrs rderkkddrs rkrdydrnpp rrdsyrdryn rrrgrsrsys
      181 rsrsrswske rlrerdrdrs rtrsrsrtrs rerdlvkpky dldrtdplen nytpvssvps
      241 issghypvpt lsstitviap thhgnnttes wsefhedqvd hnsyvrppmp kkrcrdydek
      301 gfcmrgdmcp fdhgsdpvvv edvnlpgmlp fpaqppvveg ppppglpppp piltpppvnl
      361 rppvpppgpl ppslppvtgp ppplpplqps gmdappnsat ssvptvvttg ihhqpppapp
      421 slftadtydt dgynpeapsi tntsrpmyrh rvhaqrpnli gltsgdmdlp prekppnkss
      481 mrivvdsesr krtigsgepg vptkktwfdk pnfnrtnspg fqkkvqfgne ntklelrkvp
      541 pelnniskln ehfsrfgtlv nlqvayngdp egaliqfaty eeakkaisst eavlnnrfik
      601 vywhregstq qlqttspkpl vqqpilpvvk qsvkerlgpv psstiepaea qsassdlpqn
      661 vtklsvkdrl gfvskpsvsa tekvlststg ltktvynpaa lkaaqktllv stsavdnnea
      721 qkkkqealkl qqdvrkrkqe ilekhietqk mliskleknk tmksedkaei mktlevltkn
      781 itklkdevka aspgrclpks iktktqmqke lldteldlyk kmqageevte lrrkytelql
      841 eaakrgilss grgrgihsrg rgavhgrgrg rgrgrgvpgh avvdhrpral eisaftesdr
      901 edllphfaqy geiedcqidd sslhavitfk traeaeaaav hgarfkgqdl klawnkpvtn
      961 isaveteeve pdeeereiii a
//
LOCUS       XP_047286478             984 aa            linear   PRI 05-AUG-2025
DEFINITION  RNA-binding protein 26 isoform X31 [Homo sapiens].
ACCESSION   XP_047286478
VERSION     XP_047286478.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430522.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..984
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..984
                     /product="RNA-binding protein 26 isoform X31"
                     /calculated_mol_wt=110609
     Region          11..76
                     /region_name="PWI"
                     /note="PWI domain; pfam01480"
                     /db_xref="CDD:460224"
     Region          <294..314
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Region          531..606
                     /region_name="RRM1_RBM26"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     RNA-binding protein 26 (RBM26); cd12516"
                     /db_xref="CDD:409938"
     Region          702..>794
                     /region_name="DR0291"
                     /note="Predicted nucleic acid-binding protein DR0291,
                     contains C4-type Zn-ribbon domain [General function
                     prediction only]; COG1579"
                     /db_xref="CDD:441187"
     Region          886..957
                     /region_name="RRM2_RBM26_like"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     RNA-binding protein 26 (RBM26) and similar proteins;
                     cd12258"
                     /db_xref="CDD:409703"
     CDS             1..984
                     /gene="RBM26"
                     /gene_synonym="ARRS2; C13orf10; PPP1R132; PRO1777; SE70-2;
                     ZC3H17"
                     /coded_by="XM_047430522.1:482..3436"
                     /db_xref="GeneID:64062"
                     /db_xref="HGNC:HGNC:20327"
                     /db_xref="MIM:620081"
ORIGIN      
        1 mvskmiienf ealkswlskt lepicdadps alakyvlalv kkdksekelk alcidqldvf
       61 lqketqifve klfdavntks ylpppeqpss gslkveffph qekdikkeei tkeeerekkf
      121 srrlnhsppq sssryrenrs rderkkddrs rkrdydrnpp rrdsyrdryn rrrgrsrsys
      181 rsrsrswske rlrerdrdrs rtrsrsrtrs rerdlvkpky dldrtdplen nytpvssvps
      241 issghypvpt lsstitviap thhgnnttes wsefhedqvd hnsyvrppmp kkrcrdydek
      301 gfcmrgdmcp fdhgsdpvvv edvnlpgmlp fpaqppvveg ppppglpppp piltpppvnl
      361 rppvpppgpl ppslppvtgp ppplpplqps gmdappnsat ssvptvvttg ihhqpppapp
      421 slftadtydt dgynpeapsi tntsrpmyrh rvhaqrpnli gltsgdmdlp prekppnkss
      481 mrivvdsesr krtigsgepg vptkktwfdk pnfnrtnspg fqkkvqfgne ntklelrkvp
      541 pelnniskln ehfsrfgtlv nlqvayngdp egaliqfaty eeakkaisst eavlnnrfik
      601 vywhregstq qlqttspkvm qplvqqpilp vvkqsvkerl gpvpsstiep aeaqsassdl
      661 pqnvtklsvk drlgfvskps vsatekvlst stgltktvyn paalkaaqkt llvstsavdn
      721 neaqkkkqea lklqqdvrkr kqeilekhie tqkmliskle knktmksedk aeimktlevl
      781 tknitklkde vkaaspgrcl pksiktktqm qkelldteld lykkmqagee vtelrrkyte
      841 lqleaakrgi lssgrgrgih srgrgavhgr grgrgrgrgv pghavvdhrp raleisafte
      901 sdredllphf aqygeiedcq iddsslhavi tfktraeaea aavhgarfkg qdlklawnkp
      961 vtnisavete evepdeeere iiia
//
LOCUS       XP_047286479             976 aa            linear   PRI 05-AUG-2025
DEFINITION  RNA-binding protein 26 isoform X32 [Homo sapiens].
ACCESSION   XP_047286479
VERSION     XP_047286479.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430523.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..976
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..976
                     /product="RNA-binding protein 26 isoform X32"
                     /calculated_mol_wt=109827
     Region          11..76
                     /region_name="PWI"
                     /note="PWI domain; pfam01480"
                     /db_xref="CDD:460224"
     Region          <294..314
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Region          546..621
                     /region_name="RRM1_RBM26"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     RNA-binding protein 26 (RBM26); cd12516"
                     /db_xref="CDD:409938"
     Region          693..>785
                     /region_name="DR0291"
                     /note="Predicted nucleic acid-binding protein DR0291,
                     contains C4-type Zn-ribbon domain [General function
                     prediction only]; COG1579"
                     /db_xref="CDD:441187"
     Region          877..948
                     /region_name="RRM2_RBM26_like"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     RNA-binding protein 26 (RBM26) and similar proteins;
                     cd12258"
                     /db_xref="CDD:409703"
     CDS             1..976
                     /gene="RBM26"
                     /gene_synonym="ARRS2; C13orf10; PPP1R132; PRO1777; SE70-2;
                     ZC3H17"
                     /coded_by="XM_047430523.1:482..3412"
                     /db_xref="GeneID:64062"
                     /db_xref="HGNC:HGNC:20327"
                     /db_xref="MIM:620081"
ORIGIN      
        1 mvskmiienf ealkswlskt lepicdadps alakyvlalv kkdksekelk alcidqldvf
       61 lqketqifve klfdavntks ylpppeqpss gslkveffph qekdikkeei tkeeerekkf
      121 srrlnhsppq sssryrenrs rderkkddrs rkrdydrnpp rrdsyrdryn rrrgrsrsys
      181 rsrsrswske rlrerdrdrs rtrsrsrtrs rerdlvkpky dldrtdplen nytpvssvps
      241 issghypvpt lsstitviap thhgnnttes wsefhedqvd hnsyvrppmp kkrcrdydek
      301 gfcmrgdmcp fdhgsdpvvv edvnlpgmlp fpaqppvveg ppppglpppp piltpppvnl
      361 rppvpppgpl ppslppvtdd isyslvltgp ppplpplqps gmdappnsat ssvptvvttg
      421 ihhqpppapp slftavfvlp dtydtdgynp eapsitntsr pmyrhrvhaq rpnligltsg
      481 dmdlpprekp pnkssmrivv dsesrkrtig sgepgvptkk twfdkpnfnr tnspgfqkkv
      541 qfgnentkle lrkvppelnn isklnehfsr fgtlvnlqva yngdpegali qfatyeeakk
      601 aissteavln nrfikvywhr egstqqlqtt spkvmqplvq qpilpvvkqs vkerlgpvps
      661 stiepaeaqs assdlpqvls tstgltktvy npaalkaaqk tllvstsavd nneaqkkkqe
      721 alklqqdvrk rkqeilekhi etqkmliskl eknktmksed kaeimktlev ltknitklkd
      781 evkaaspgrc lpksiktktq mqkelldtel dlykkmqage evtelrrkyt elqleaakrg
      841 ilssgrgrgi hsrgrgavhg rgrgrgrgrg vpghavvdhr praleisaft esdredllph
      901 faqygeiedc qiddsslhav itfktraeae aaavhgarfk gqdlklawnk pvtnisavet
      961 eevepdeeeq reiiia
//
LOCUS       XP_047286480             975 aa            linear   PRI 05-AUG-2025
DEFINITION  RNA-binding protein 26 isoform X33 [Homo sapiens].
ACCESSION   XP_047286480
VERSION     XP_047286480.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430524.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..975
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..975
                     /product="RNA-binding protein 26 isoform X33"
                     /calculated_mol_wt=109699
     Region          11..76
                     /region_name="PWI"
                     /note="PWI domain; pfam01480"
                     /db_xref="CDD:460224"
     Region          <294..314
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Region          546..621
                     /region_name="RRM1_RBM26"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     RNA-binding protein 26 (RBM26); cd12516"
                     /db_xref="CDD:409938"
     Region          693..>785
                     /region_name="DR0291"
                     /note="Predicted nucleic acid-binding protein DR0291,
                     contains C4-type Zn-ribbon domain [General function
                     prediction only]; COG1579"
                     /db_xref="CDD:441187"
     Region          877..948
                     /region_name="RRM2_RBM26_like"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     RNA-binding protein 26 (RBM26) and similar proteins;
                     cd12258"
                     /db_xref="CDD:409703"
     CDS             1..975
                     /gene="RBM26"
                     /gene_synonym="ARRS2; C13orf10; PPP1R132; PRO1777; SE70-2;
                     ZC3H17"
                     /coded_by="XM_047430524.1:482..3409"
                     /db_xref="GeneID:64062"
                     /db_xref="HGNC:HGNC:20327"
                     /db_xref="MIM:620081"
ORIGIN      
        1 mvskmiienf ealkswlskt lepicdadps alakyvlalv kkdksekelk alcidqldvf
       61 lqketqifve klfdavntks ylpppeqpss gslkveffph qekdikkeei tkeeerekkf
      121 srrlnhsppq sssryrenrs rderkkddrs rkrdydrnpp rrdsyrdryn rrrgrsrsys
      181 rsrsrswske rlrerdrdrs rtrsrsrtrs rerdlvkpky dldrtdplen nytpvssvps
      241 issghypvpt lsstitviap thhgnnttes wsefhedqvd hnsyvrppmp kkrcrdydek
      301 gfcmrgdmcp fdhgsdpvvv edvnlpgmlp fpaqppvveg ppppglpppp piltpppvnl
      361 rppvpppgpl ppslppvtdd isyslvltgp ppplpplqps gmdappnsat ssvptvvttg
      421 ihhqpppapp slftavfvlp dtydtdgynp eapsitntsr pmyrhrvhaq rpnligltsg
      481 dmdlpprekp pnkssmrivv dsesrkrtig sgepgvptkk twfdkpnfnr tnspgfqkkv
      541 qfgnentkle lrkvppelnn isklnehfsr fgtlvnlqva yngdpegali qfatyeeakk
      601 aissteavln nrfikvywhr egstqqlqtt spkvmqplvq qpilpvvkqs vkerlgpvps
      661 stiepaeaqs assdlpqvls tstgltktvy npaalkaaqk tllvstsavd nneaqkkkqe
      721 alklqqdvrk rkqeilekhi etqkmliskl eknktmksed kaeimktlev ltknitklkd
      781 evkaaspgrc lpksiktktq mqkelldtel dlykkmqage evtelrrkyt elqleaakrg
      841 ilssgrgrgi hsrgrgavhg rgrgrgrgrg vpghavvdhr praleisaft esdredllph
      901 faqygeiedc qiddsslhav itfktraeae aaavhgarfk gqdlklawnk pvtnisavet
      961 eevepdeeer eiiia
//
LOCUS       XP_047286481             973 aa            linear   PRI 05-AUG-2025
DEFINITION  RNA-binding protein 26 isoform X34 [Homo sapiens].
ACCESSION   XP_047286481
VERSION     XP_047286481.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430525.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..973
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..973
                     /product="RNA-binding protein 26 isoform X34"
                     /calculated_mol_wt=109469
     Region          11..76
                     /region_name="PWI"
                     /note="PWI domain; pfam01480"
                     /db_xref="CDD:460224"
     Region          <294..314
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Region          546..621
                     /region_name="RRM1_RBM26"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     RNA-binding protein 26 (RBM26); cd12516"
                     /db_xref="CDD:409938"
     Region          690..>782
                     /region_name="DR0291"
                     /note="Predicted nucleic acid-binding protein DR0291,
                     contains C4-type Zn-ribbon domain [General function
                     prediction only]; COG1579"
                     /db_xref="CDD:441187"
     Region          874..945
                     /region_name="RRM2_RBM26_like"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     RNA-binding protein 26 (RBM26) and similar proteins;
                     cd12258"
                     /db_xref="CDD:409703"
     CDS             1..973
                     /gene="RBM26"
                     /gene_synonym="ARRS2; C13orf10; PPP1R132; PRO1777; SE70-2;
                     ZC3H17"
                     /coded_by="XM_047430525.1:482..3403"
                     /db_xref="GeneID:64062"
                     /db_xref="HGNC:HGNC:20327"
                     /db_xref="MIM:620081"
ORIGIN      
        1 mvskmiienf ealkswlskt lepicdadps alakyvlalv kkdksekelk alcidqldvf
       61 lqketqifve klfdavntks ylpppeqpss gslkveffph qekdikkeei tkeeerekkf
      121 srrlnhsppq sssryrenrs rderkkddrs rkrdydrnpp rrdsyrdryn rrrgrsrsys
      181 rsrsrswske rlrerdrdrs rtrsrsrtrs rerdlvkpky dldrtdplen nytpvssvps
      241 issghypvpt lsstitviap thhgnnttes wsefhedqvd hnsyvrppmp kkrcrdydek
      301 gfcmrgdmcp fdhgsdpvvv edvnlpgmlp fpaqppvveg ppppglpppp piltpppvnl
      361 rppvpppgpl ppslppvtdd isyslvltgp ppplpplqps gmdappnsat ssvptvvttg
      421 ihhqpppapp slftavfvlp dtydtdgynp eapsitntsr pmyrhrvhaq rpnligltsg
      481 dmdlpprekp pnkssmrivv dsesrkrtig sgepgvptkk twfdkpnfnr tnspgfqkkv
      541 qfgnentkle lrkvppelnn isklnehfsr fgtlvnlqva yngdpegali qfatyeeakk
      601 aissteavln nrfikvywhr egstqqlqtt spkplvqqpi lpvvkqsvke rlgpvpssti
      661 epaeaqsass dlpqvlstst gltktvynpa alkaaqktll vstsavdnne aqkkkqealk
      721 lqqdvrkrkq eilekhietq kmlisklekn ktmksedkae imktlevltk nitklkdevk
      781 aaspgrclpk siktktqmqk elldteldly kkmqageevt elrrkytelq leaakrgils
      841 sgrgrgihsr grgavhgrgr grgrgrgvpg havvdhrpra leisaftesd redllphfaq
      901 ygeiedcqid dsslhavitf ktraeaeaaa vhgarfkgqd lklawnkpvt nisaveteev
      961 epdeeeqrei iia
//
LOCUS       XP_047286482             972 aa            linear   PRI 05-AUG-2025
DEFINITION  RNA-binding protein 26 isoform X35 [Homo sapiens].
ACCESSION   XP_047286482
VERSION     XP_047286482.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430526.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..972
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..972
                     /product="RNA-binding protein 26 isoform X35"
                     /calculated_mol_wt=109340
     Region          11..76
                     /region_name="PWI"
                     /note="PWI domain; pfam01480"
                     /db_xref="CDD:460224"
     Region          <294..314
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Region          546..621
                     /region_name="RRM1_RBM26"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     RNA-binding protein 26 (RBM26); cd12516"
                     /db_xref="CDD:409938"
     Region          690..>782
                     /region_name="DR0291"
                     /note="Predicted nucleic acid-binding protein DR0291,
                     contains C4-type Zn-ribbon domain [General function
                     prediction only]; COG1579"
                     /db_xref="CDD:441187"
     Region          874..945
                     /region_name="RRM2_RBM26_like"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     RNA-binding protein 26 (RBM26) and similar proteins;
                     cd12258"
                     /db_xref="CDD:409703"
     CDS             1..972
                     /gene="RBM26"
                     /gene_synonym="ARRS2; C13orf10; PPP1R132; PRO1777; SE70-2;
                     ZC3H17"
                     /coded_by="XM_047430526.1:482..3400"
                     /db_xref="GeneID:64062"
                     /db_xref="HGNC:HGNC:20327"
                     /db_xref="MIM:620081"
ORIGIN      
        1 mvskmiienf ealkswlskt lepicdadps alakyvlalv kkdksekelk alcidqldvf
       61 lqketqifve klfdavntks ylpppeqpss gslkveffph qekdikkeei tkeeerekkf
      121 srrlnhsppq sssryrenrs rderkkddrs rkrdydrnpp rrdsyrdryn rrrgrsrsys
      181 rsrsrswske rlrerdrdrs rtrsrsrtrs rerdlvkpky dldrtdplen nytpvssvps
      241 issghypvpt lsstitviap thhgnnttes wsefhedqvd hnsyvrppmp kkrcrdydek
      301 gfcmrgdmcp fdhgsdpvvv edvnlpgmlp fpaqppvveg ppppglpppp piltpppvnl
      361 rppvpppgpl ppslppvtdd isyslvltgp ppplpplqps gmdappnsat ssvptvvttg
      421 ihhqpppapp slftavfvlp dtydtdgynp eapsitntsr pmyrhrvhaq rpnligltsg
      481 dmdlpprekp pnkssmrivv dsesrkrtig sgepgvptkk twfdkpnfnr tnspgfqkkv
      541 qfgnentkle lrkvppelnn isklnehfsr fgtlvnlqva yngdpegali qfatyeeakk
      601 aissteavln nrfikvywhr egstqqlqtt spkplvqqpi lpvvkqsvke rlgpvpssti
      661 epaeaqsass dlpqvlstst gltktvynpa alkaaqktll vstsavdnne aqkkkqealk
      721 lqqdvrkrkq eilekhietq kmlisklekn ktmksedkae imktlevltk nitklkdevk
      781 aaspgrclpk siktktqmqk elldteldly kkmqageevt elrrkytelq leaakrgils
      841 sgrgrgihsr grgavhgrgr grgrgrgvpg havvdhrpra leisaftesd redllphfaq
      901 ygeiedcqid dsslhavitf ktraeaeaaa vhgarfkgqd lklawnkpvt nisaveteev
      961 epdeeereii ia
//
LOCUS       XP_047286483             971 aa            linear   PRI 05-AUG-2025
DEFINITION  RNA-binding protein 26 isoform X36 [Homo sapiens].
ACCESSION   XP_047286483
VERSION     XP_047286483.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430527.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..971
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..971
                     /product="RNA-binding protein 26 isoform X36"
                     /calculated_mol_wt=109271
     Region          11..76
                     /region_name="PWI"
                     /note="PWI domain; pfam01480"
                     /db_xref="CDD:460224"
     Region          <294..314
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Region          541..616
                     /region_name="RRM1_RBM26"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     RNA-binding protein 26 (RBM26); cd12516"
                     /db_xref="CDD:409938"
     Region          688..>780
                     /region_name="DR0291"
                     /note="Predicted nucleic acid-binding protein DR0291,
                     contains C4-type Zn-ribbon domain [General function
                     prediction only]; COG1579"
                     /db_xref="CDD:441187"
     Region          872..943
                     /region_name="RRM2_RBM26_like"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     RNA-binding protein 26 (RBM26) and similar proteins;
                     cd12258"
                     /db_xref="CDD:409703"
     CDS             1..971
                     /gene="RBM26"
                     /gene_synonym="ARRS2; C13orf10; PPP1R132; PRO1777; SE70-2;
                     ZC3H17"
                     /coded_by="XM_047430527.1:482..3397"
                     /db_xref="GeneID:64062"
                     /db_xref="HGNC:HGNC:20327"
                     /db_xref="MIM:620081"
ORIGIN      
        1 mvskmiienf ealkswlskt lepicdadps alakyvlalv kkdksekelk alcidqldvf
       61 lqketqifve klfdavntks ylpppeqpss gslkveffph qekdikkeei tkeeerekkf
      121 srrlnhsppq sssryrenrs rderkkddrs rkrdydrnpp rrdsyrdryn rrrgrsrsys
      181 rsrsrswske rlrerdrdrs rtrsrsrtrs rerdlvkpky dldrtdplen nytpvssvps
      241 issghypvpt lsstitviap thhgnnttes wsefhedqvd hnsyvrppmp kkrcrdydek
      301 gfcmrgdmcp fdhgsdpvvv edvnlpgmlp fpaqppvveg ppppglpppp piltpppvnl
      361 rppvpppgpl ppslppvtdd isyslvltgp ppplpplqps gmdappnsat ssvptvvttg
      421 ihhqpppapp slftadtydt dgynpeapsi tntsrpmyrh rvhaqrpnli gltsgdmdlp
      481 prekppnkss mrivvdsesr krtigsgepg vptkktwfdk pnfnrtnspg fqkkvqfgne
      541 ntklelrkvp pelnniskln ehfsrfgtlv nlqvayngdp egaliqfaty eeakkaisst
      601 eavlnnrfik vywhregstq qlqttspkvm qplvqqpilp vvkqsvkerl gpvpsstiep
      661 aeaqsassdl pqvlststgl tktvynpaal kaaqktllvs tsavdnneaq kkkqealklq
      721 qdvrkrkqei lekhietqkm liskleknkt mksedkaeim ktlevltkni tklkdevkaa
      781 spgrclpksi ktktqmqkel ldteldlykk mqageevtel rrkytelqle aakrgilssg
      841 rgrgihsrgr gavhgrgrgr grgrgvpgha vvdhrprale isaftesdre dllphfaqyg
      901 eiedcqidds slhavitfkt raeaeaaavh garfkgqdlk lawnkpvtni saveteevep
      961 deeeqreiii a
//
LOCUS       XP_047286484             968 aa            linear   PRI 05-AUG-2025
DEFINITION  RNA-binding protein 26 isoform X37 [Homo sapiens].
ACCESSION   XP_047286484
VERSION     XP_047286484.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430528.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..968
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..968
                     /product="RNA-binding protein 26 isoform X37"
                     /calculated_mol_wt=108913
     Region          11..76
                     /region_name="PWI"
                     /note="PWI domain; pfam01480"
                     /db_xref="CDD:460224"
     Region          <294..314
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Region          541..616
                     /region_name="RRM1_RBM26"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     RNA-binding protein 26 (RBM26); cd12516"
                     /db_xref="CDD:409938"
     Region          685..>777
                     /region_name="DR0291"
                     /note="Predicted nucleic acid-binding protein DR0291,
                     contains C4-type Zn-ribbon domain [General function
                     prediction only]; COG1579"
                     /db_xref="CDD:441187"
     Region          869..940
                     /region_name="RRM2_RBM26_like"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     RNA-binding protein 26 (RBM26) and similar proteins;
                     cd12258"
                     /db_xref="CDD:409703"
     CDS             1..968
                     /gene="RBM26"
                     /gene_synonym="ARRS2; C13orf10; PPP1R132; PRO1777; SE70-2;
                     ZC3H17"
                     /coded_by="XM_047430528.1:482..3388"
                     /db_xref="GeneID:64062"
                     /db_xref="HGNC:HGNC:20327"
                     /db_xref="MIM:620081"
ORIGIN      
        1 mvskmiienf ealkswlskt lepicdadps alakyvlalv kkdksekelk alcidqldvf
       61 lqketqifve klfdavntks ylpppeqpss gslkveffph qekdikkeei tkeeerekkf
      121 srrlnhsppq sssryrenrs rderkkddrs rkrdydrnpp rrdsyrdryn rrrgrsrsys
      181 rsrsrswske rlrerdrdrs rtrsrsrtrs rerdlvkpky dldrtdplen nytpvssvps
      241 issghypvpt lsstitviap thhgnnttes wsefhedqvd hnsyvrppmp kkrcrdydek
      301 gfcmrgdmcp fdhgsdpvvv edvnlpgmlp fpaqppvveg ppppglpppp piltpppvnl
      361 rppvpppgpl ppslppvtdd isyslvltgp ppplpplqps gmdappnsat ssvptvvttg
      421 ihhqpppapp slftadtydt dgynpeapsi tntsrpmyrh rvhaqrpnli gltsgdmdlp
      481 prekppnkss mrivvdsesr krtigsgepg vptkktwfdk pnfnrtnspg fqkkvqfgne
      541 ntklelrkvp pelnniskln ehfsrfgtlv nlqvayngdp egaliqfaty eeakkaisst
      601 eavlnnrfik vywhregstq qlqttspkpl vqqpilpvvk qsvkerlgpv psstiepaea
      661 qsassdlpqv lststgltkt vynpaalkaa qktllvstsa vdnneaqkkk qealklqqdv
      721 rkrkqeilek hietqkmlis kleknktmks edkaeimktl evltknitkl kdevkaaspg
      781 rclpksiktk tqmqkelldt eldlykkmqa geevtelrrk ytelqleaak rgilssgrgr
      841 gihsrgrgav hgrgrgrgrg rgvpghavvd hrpraleisa ftesdredll phfaqygeie
      901 dcqiddsslh avitfktrae aeaaavhgar fkgqdlklaw nkpvtnisav eteevepdee
      961 eqreiiia
//
LOCUS       XP_047286485             970 aa            linear   PRI 05-AUG-2025
DEFINITION  RNA-binding protein 26 isoform X38 [Homo sapiens].
ACCESSION   XP_047286485
VERSION     XP_047286485.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430529.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..970
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..970
                     /product="RNA-binding protein 26 isoform X38"
                     /calculated_mol_wt=109143
     Region          11..76
                     /region_name="PWI"
                     /note="PWI domain; pfam01480"
                     /db_xref="CDD:460224"
     Region          <294..314
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Region          541..616
                     /region_name="RRM1_RBM26"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     RNA-binding protein 26 (RBM26); cd12516"
                     /db_xref="CDD:409938"
     Region          688..>780
                     /region_name="DR0291"
                     /note="Predicted nucleic acid-binding protein DR0291,
                     contains C4-type Zn-ribbon domain [General function
                     prediction only]; COG1579"
                     /db_xref="CDD:441187"
     Region          872..943
                     /region_name="RRM2_RBM26_like"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     RNA-binding protein 26 (RBM26) and similar proteins;
                     cd12258"
                     /db_xref="CDD:409703"
     CDS             1..970
                     /gene="RBM26"
                     /gene_synonym="ARRS2; C13orf10; PPP1R132; PRO1777; SE70-2;
                     ZC3H17"
                     /coded_by="XM_047430529.1:482..3394"
                     /db_xref="GeneID:64062"
                     /db_xref="HGNC:HGNC:20327"
                     /db_xref="MIM:620081"
ORIGIN      
        1 mvskmiienf ealkswlskt lepicdadps alakyvlalv kkdksekelk alcidqldvf
       61 lqketqifve klfdavntks ylpppeqpss gslkveffph qekdikkeei tkeeerekkf
      121 srrlnhsppq sssryrenrs rderkkddrs rkrdydrnpp rrdsyrdryn rrrgrsrsys
      181 rsrsrswske rlrerdrdrs rtrsrsrtrs rerdlvkpky dldrtdplen nytpvssvps
      241 issghypvpt lsstitviap thhgnnttes wsefhedqvd hnsyvrppmp kkrcrdydek
      301 gfcmrgdmcp fdhgsdpvvv edvnlpgmlp fpaqppvveg ppppglpppp piltpppvnl
      361 rppvpppgpl ppslppvtdd isyslvltgp ppplpplqps gmdappnsat ssvptvvttg
      421 ihhqpppapp slftadtydt dgynpeapsi tntsrpmyrh rvhaqrpnli gltsgdmdlp
      481 prekppnkss mrivvdsesr krtigsgepg vptkktwfdk pnfnrtnspg fqkkvqfgne
      541 ntklelrkvp pelnniskln ehfsrfgtlv nlqvayngdp egaliqfaty eeakkaisst
      601 eavlnnrfik vywhregstq qlqttspkvm qplvqqpilp vvkqsvkerl gpvpsstiep
      661 aeaqsassdl pqvlststgl tktvynpaal kaaqktllvs tsavdnneaq kkkqealklq
      721 qdvrkrkqei lekhietqkm liskleknkt mksedkaeim ktlevltkni tklkdevkaa
      781 spgrclpksi ktktqmqkel ldteldlykk mqageevtel rrkytelqle aakrgilssg
      841 rgrgihsrgr gavhgrgrgr grgrgvpgha vvdhrprale isaftesdre dllphfaqyg
      901 eiedcqidds slhavitfkt raeaeaaavh garfkgqdlk lawnkpvtni saveteevep
      961 deeereiiia
//
LOCUS       XP_047286486             966 aa            linear   PRI 05-AUG-2025
DEFINITION  RNA-binding protein 26 isoform X39 [Homo sapiens].
ACCESSION   XP_047286486
VERSION     XP_047286486.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430530.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..966
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..966
                     /product="RNA-binding protein 26 isoform X39"
                     /calculated_mol_wt=108720
     Region          11..76
                     /region_name="PWI"
                     /note="PWI domain; pfam01480"
                     /db_xref="CDD:460224"
     Region          <294..314
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Region          536..611
                     /region_name="RRM1_RBM26"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     RNA-binding protein 26 (RBM26); cd12516"
                     /db_xref="CDD:409938"
     Region          683..>775
                     /region_name="DR0291"
                     /note="Predicted nucleic acid-binding protein DR0291,
                     contains C4-type Zn-ribbon domain [General function
                     prediction only]; COG1579"
                     /db_xref="CDD:441187"
     Region          867..938
                     /region_name="RRM2_RBM26_like"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     RNA-binding protein 26 (RBM26) and similar proteins;
                     cd12258"
                     /db_xref="CDD:409703"
     CDS             1..966
                     /gene="RBM26"
                     /gene_synonym="ARRS2; C13orf10; PPP1R132; PRO1777; SE70-2;
                     ZC3H17"
                     /coded_by="XM_047430530.1:482..3382"
                     /db_xref="GeneID:64062"
                     /db_xref="HGNC:HGNC:20327"
                     /db_xref="MIM:620081"
ORIGIN      
        1 mvskmiienf ealkswlskt lepicdadps alakyvlalv kkdksekelk alcidqldvf
       61 lqketqifve klfdavntks ylpppeqpss gslkveffph qekdikkeei tkeeerekkf
      121 srrlnhsppq sssryrenrs rderkkddrs rkrdydrnpp rrdsyrdryn rrrgrsrsys
      181 rsrsrswske rlrerdrdrs rtrsrsrtrs rerdlvkpky dldrtdplen nytpvssvps
      241 issghypvpt lsstitviap thhgnnttes wsefhedqvd hnsyvrppmp kkrcrdydek
      301 gfcmrgdmcp fdhgsdpvvv edvnlpgmlp fpaqppvveg ppppglpppp piltpppvnl
      361 rppvpppgpl ppslppvtgp ppplpplqps gmdappnsat ssvptvvttg ihhqpppapp
      421 slftavfvlp dtydtdgynp eapsitntsr pmyrhrvhaq rpnligltsg dmdlpprekp
      481 pnkssmrivv dsesrkrtig sgepgvptkk twfdkpnfnr tnspgfqkkv qfgnentkle
      541 lrkvppelnn isklnehfsr fgtlvnlqva yngdpegali qfatyeeakk aissteavln
      601 nrfikvywhr egstqqlqtt spkvmqplvq qpilpvvkqs vkerlgpvps stiepaeaqs
      661 assdlpqvls tstgltktvy npaalkaaqk tllvstsavd nneaqkkkqe alklqqdvrk
      721 rkqeilekhi etqkmliskl eknktmksed kaeimktlev ltknitklkd evkaaspgrc
      781 lpksiktktq mqkelldtel dlykkmqage evtelrrkyt elqleaakrg ilssgrgrgi
      841 hsrgrgavhg rgrgrgrgrg vpghavvdhr praleisaft esdredllph faqygeiedc
      901 qiddsslhav itfktraeae aaavhgarfk gqdlklawnk pvtnisavet eevepdeeeq
      961 reiiia
//
LOCUS       XP_047286487             965 aa            linear   PRI 05-AUG-2025
DEFINITION  RNA-binding protein 26 isoform X40 [Homo sapiens].
ACCESSION   XP_047286487
VERSION     XP_047286487.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430531.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..965
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..965
                     /product="RNA-binding protein 26 isoform X40"
                     /calculated_mol_wt=108592
     Region          11..76
                     /region_name="PWI"
                     /note="PWI domain; pfam01480"
                     /db_xref="CDD:460224"
     Region          <294..314
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Region          536..611
                     /region_name="RRM1_RBM26"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     RNA-binding protein 26 (RBM26); cd12516"
                     /db_xref="CDD:409938"
     Region          683..>775
                     /region_name="DR0291"
                     /note="Predicted nucleic acid-binding protein DR0291,
                     contains C4-type Zn-ribbon domain [General function
                     prediction only]; COG1579"
                     /db_xref="CDD:441187"
     Region          867..938
                     /region_name="RRM2_RBM26_like"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     RNA-binding protein 26 (RBM26) and similar proteins;
                     cd12258"
                     /db_xref="CDD:409703"
     CDS             1..965
                     /gene="RBM26"
                     /gene_synonym="ARRS2; C13orf10; PPP1R132; PRO1777; SE70-2;
                     ZC3H17"
                     /coded_by="XM_047430531.1:482..3379"
                     /db_xref="GeneID:64062"
                     /db_xref="HGNC:HGNC:20327"
                     /db_xref="MIM:620081"
ORIGIN      
        1 mvskmiienf ealkswlskt lepicdadps alakyvlalv kkdksekelk alcidqldvf
       61 lqketqifve klfdavntks ylpppeqpss gslkveffph qekdikkeei tkeeerekkf
      121 srrlnhsppq sssryrenrs rderkkddrs rkrdydrnpp rrdsyrdryn rrrgrsrsys
      181 rsrsrswske rlrerdrdrs rtrsrsrtrs rerdlvkpky dldrtdplen nytpvssvps
      241 issghypvpt lsstitviap thhgnnttes wsefhedqvd hnsyvrppmp kkrcrdydek
      301 gfcmrgdmcp fdhgsdpvvv edvnlpgmlp fpaqppvveg ppppglpppp piltpppvnl
      361 rppvpppgpl ppslppvtgp ppplpplqps gmdappnsat ssvptvvttg ihhqpppapp
      421 slftavfvlp dtydtdgynp eapsitntsr pmyrhrvhaq rpnligltsg dmdlpprekp
      481 pnkssmrivv dsesrkrtig sgepgvptkk twfdkpnfnr tnspgfqkkv qfgnentkle
      541 lrkvppelnn isklnehfsr fgtlvnlqva yngdpegali qfatyeeakk aissteavln
      601 nrfikvywhr egstqqlqtt spkvmqplvq qpilpvvkqs vkerlgpvps stiepaeaqs
      661 assdlpqvls tstgltktvy npaalkaaqk tllvstsavd nneaqkkkqe alklqqdvrk
      721 rkqeilekhi etqkmliskl eknktmksed kaeimktlev ltknitklkd evkaaspgrc
      781 lpksiktktq mqkelldtel dlykkmqage evtelrrkyt elqleaakrg ilssgrgrgi
      841 hsrgrgavhg rgrgrgrgrg vpghavvdhr praleisaft esdredllph faqygeiedc
      901 qiddsslhav itfktraeae aaavhgarfk gqdlklawnk pvtnisavet eevepdeeer
      961 eiiia
//
LOCUS       XP_047286488             963 aa            linear   PRI 05-AUG-2025
DEFINITION  RNA-binding protein 26 isoform X41 [Homo sapiens].
ACCESSION   XP_047286488
VERSION     XP_047286488.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430532.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..963
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..963
                     /product="RNA-binding protein 26 isoform X41"
                     /calculated_mol_wt=108361
     Region          11..76
                     /region_name="PWI"
                     /note="PWI domain; pfam01480"
                     /db_xref="CDD:460224"
     Region          <294..314
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Region          536..611
                     /region_name="RRM1_RBM26"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     RNA-binding protein 26 (RBM26); cd12516"
                     /db_xref="CDD:409938"
     Region          680..>772
                     /region_name="DR0291"
                     /note="Predicted nucleic acid-binding protein DR0291,
                     contains C4-type Zn-ribbon domain [General function
                     prediction only]; COG1579"
                     /db_xref="CDD:441187"
     Region          864..935
                     /region_name="RRM2_RBM26_like"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     RNA-binding protein 26 (RBM26) and similar proteins;
                     cd12258"
                     /db_xref="CDD:409703"
     CDS             1..963
                     /gene="RBM26"
                     /gene_synonym="ARRS2; C13orf10; PPP1R132; PRO1777; SE70-2;
                     ZC3H17"
                     /coded_by="XM_047430532.1:482..3373"
                     /db_xref="GeneID:64062"
                     /db_xref="HGNC:HGNC:20327"
                     /db_xref="MIM:620081"
ORIGIN      
        1 mvskmiienf ealkswlskt lepicdadps alakyvlalv kkdksekelk alcidqldvf
       61 lqketqifve klfdavntks ylpppeqpss gslkveffph qekdikkeei tkeeerekkf
      121 srrlnhsppq sssryrenrs rderkkddrs rkrdydrnpp rrdsyrdryn rrrgrsrsys
      181 rsrsrswske rlrerdrdrs rtrsrsrtrs rerdlvkpky dldrtdplen nytpvssvps
      241 issghypvpt lsstitviap thhgnnttes wsefhedqvd hnsyvrppmp kkrcrdydek
      301 gfcmrgdmcp fdhgsdpvvv edvnlpgmlp fpaqppvveg ppppglpppp piltpppvnl
      361 rppvpppgpl ppslppvtgp ppplpplqps gmdappnsat ssvptvvttg ihhqpppapp
      421 slftavfvlp dtydtdgynp eapsitntsr pmyrhrvhaq rpnligltsg dmdlpprekp
      481 pnkssmrivv dsesrkrtig sgepgvptkk twfdkpnfnr tnspgfqkkv qfgnentkle
      541 lrkvppelnn isklnehfsr fgtlvnlqva yngdpegali qfatyeeakk aissteavln
      601 nrfikvywhr egstqqlqtt spkplvqqpi lpvvkqsvke rlgpvpssti epaeaqsass
      661 dlpqvlstst gltktvynpa alkaaqktll vstsavdnne aqkkkqealk lqqdvrkrkq
      721 eilekhietq kmlisklekn ktmksedkae imktlevltk nitklkdevk aaspgrclpk
      781 siktktqmqk elldteldly kkmqageevt elrrkytelq leaakrgils sgrgrgihsr
      841 grgavhgrgr grgrgrgvpg havvdhrpra leisaftesd redllphfaq ygeiedcqid
      901 dsslhavitf ktraeaeaaa vhgarfkgqd lklawnkpvt nisaveteev epdeeeqrei
      961 iia
//
LOCUS       XP_047286489             961 aa            linear   PRI 05-AUG-2025
DEFINITION  RNA-binding protein 26 isoform X42 [Homo sapiens].
ACCESSION   XP_047286489
VERSION     XP_047286489.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430533.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..961
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..961
                     /product="RNA-binding protein 26 isoform X42"
                     /calculated_mol_wt=108164
     Region          11..76
                     /region_name="PWI"
                     /note="PWI domain; pfam01480"
                     /db_xref="CDD:460224"
     Region          <294..314
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Region          531..606
                     /region_name="RRM1_RBM26"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     RNA-binding protein 26 (RBM26); cd12516"
                     /db_xref="CDD:409938"
     Region          678..>770
                     /region_name="DR0291"
                     /note="Predicted nucleic acid-binding protein DR0291,
                     contains C4-type Zn-ribbon domain [General function
                     prediction only]; COG1579"
                     /db_xref="CDD:441187"
     Region          862..933
                     /region_name="RRM2_RBM26_like"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     RNA-binding protein 26 (RBM26) and similar proteins;
                     cd12258"
                     /db_xref="CDD:409703"
     CDS             1..961
                     /gene="RBM26"
                     /gene_synonym="ARRS2; C13orf10; PPP1R132; PRO1777; SE70-2;
                     ZC3H17"
                     /coded_by="XM_047430533.1:482..3367"
                     /db_xref="GeneID:64062"
                     /db_xref="HGNC:HGNC:20327"
                     /db_xref="MIM:620081"
ORIGIN      
        1 mvskmiienf ealkswlskt lepicdadps alakyvlalv kkdksekelk alcidqldvf
       61 lqketqifve klfdavntks ylpppeqpss gslkveffph qekdikkeei tkeeerekkf
      121 srrlnhsppq sssryrenrs rderkkddrs rkrdydrnpp rrdsyrdryn rrrgrsrsys
      181 rsrsrswske rlrerdrdrs rtrsrsrtrs rerdlvkpky dldrtdplen nytpvssvps
      241 issghypvpt lsstitviap thhgnnttes wsefhedqvd hnsyvrppmp kkrcrdydek
      301 gfcmrgdmcp fdhgsdpvvv edvnlpgmlp fpaqppvveg ppppglpppp piltpppvnl
      361 rppvpppgpl ppslppvtgp ppplpplqps gmdappnsat ssvptvvttg ihhqpppapp
      421 slftadtydt dgynpeapsi tntsrpmyrh rvhaqrpnli gltsgdmdlp prekppnkss
      481 mrivvdsesr krtigsgepg vptkktwfdk pnfnrtnspg fqkkvqfgne ntklelrkvp
      541 pelnniskln ehfsrfgtlv nlqvayngdp egaliqfaty eeakkaisst eavlnnrfik
      601 vywhregstq qlqttspkvm qplvqqpilp vvkqsvkerl gpvpsstiep aeaqsassdl
      661 pqvlststgl tktvynpaal kaaqktllvs tsavdnneaq kkkqealklq qdvrkrkqei
      721 lekhietqkm liskleknkt mksedkaeim ktlevltkni tklkdevkaa spgrclpksi
      781 ktktqmqkel ldteldlykk mqageevtel rrkytelqle aakrgilssg rgrgihsrgr
      841 gavhgrgrgr grgrgvpgha vvdhrprale isaftesdre dllphfaqyg eiedcqidds
      901 slhavitfkt raeaeaaavh garfkgqdlk lawnkpvtni saveteevep deeeqreiii
      961 a
//
LOCUS       XP_047286490             960 aa            linear   PRI 05-AUG-2025
DEFINITION  RNA-binding protein 26 isoform X43 [Homo sapiens].
ACCESSION   XP_047286490
VERSION     XP_047286490.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430534.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..960
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..960
                     /product="RNA-binding protein 26 isoform X43"
                     /calculated_mol_wt=108036
     Region          11..76
                     /region_name="PWI"
                     /note="PWI domain; pfam01480"
                     /db_xref="CDD:460224"
     Region          <294..314
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Region          531..606
                     /region_name="RRM1_RBM26"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     RNA-binding protein 26 (RBM26); cd12516"
                     /db_xref="CDD:409938"
     Region          678..>770
                     /region_name="DR0291"
                     /note="Predicted nucleic acid-binding protein DR0291,
                     contains C4-type Zn-ribbon domain [General function
                     prediction only]; COG1579"
                     /db_xref="CDD:441187"
     Region          862..933
                     /region_name="RRM2_RBM26_like"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     RNA-binding protein 26 (RBM26) and similar proteins;
                     cd12258"
                     /db_xref="CDD:409703"
     CDS             1..960
                     /gene="RBM26"
                     /gene_synonym="ARRS2; C13orf10; PPP1R132; PRO1777; SE70-2;
                     ZC3H17"
                     /coded_by="XM_047430534.1:482..3364"
                     /db_xref="GeneID:64062"
                     /db_xref="HGNC:HGNC:20327"
                     /db_xref="MIM:620081"
ORIGIN      
        1 mvskmiienf ealkswlskt lepicdadps alakyvlalv kkdksekelk alcidqldvf
       61 lqketqifve klfdavntks ylpppeqpss gslkveffph qekdikkeei tkeeerekkf
      121 srrlnhsppq sssryrenrs rderkkddrs rkrdydrnpp rrdsyrdryn rrrgrsrsys
      181 rsrsrswske rlrerdrdrs rtrsrsrtrs rerdlvkpky dldrtdplen nytpvssvps
      241 issghypvpt lsstitviap thhgnnttes wsefhedqvd hnsyvrppmp kkrcrdydek
      301 gfcmrgdmcp fdhgsdpvvv edvnlpgmlp fpaqppvveg ppppglpppp piltpppvnl
      361 rppvpppgpl ppslppvtgp ppplpplqps gmdappnsat ssvptvvttg ihhqpppapp
      421 slftadtydt dgynpeapsi tntsrpmyrh rvhaqrpnli gltsgdmdlp prekppnkss
      481 mrivvdsesr krtigsgepg vptkktwfdk pnfnrtnspg fqkkvqfgne ntklelrkvp
      541 pelnniskln ehfsrfgtlv nlqvayngdp egaliqfaty eeakkaisst eavlnnrfik
      601 vywhregstq qlqttspkvm qplvqqpilp vvkqsvkerl gpvpsstiep aeaqsassdl
      661 pqvlststgl tktvynpaal kaaqktllvs tsavdnneaq kkkqealklq qdvrkrkqei
      721 lekhietqkm liskleknkt mksedkaeim ktlevltkni tklkdevkaa spgrclpksi
      781 ktktqmqkel ldteldlykk mqageevtel rrkytelqle aakrgilssg rgrgihsrgr
      841 gavhgrgrgr grgrgvpgha vvdhrprale isaftesdre dllphfaqyg eiedcqidds
      901 slhavitfkt raeaeaaavh garfkgqdlk lawnkpvtni saveteevep deeereiiia
//
LOCUS       XP_047286491             958 aa            linear   PRI 05-AUG-2025
DEFINITION  RNA-binding protein 26 isoform X44 [Homo sapiens].
ACCESSION   XP_047286491
VERSION     XP_047286491.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430535.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..958
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..958
                     /product="RNA-binding protein 26 isoform X44"
                     /calculated_mol_wt=107806
     Region          11..76
                     /region_name="PWI"
                     /note="PWI domain; pfam01480"
                     /db_xref="CDD:460224"
     Region          <294..314
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Region          531..606
                     /region_name="RRM1_RBM26"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     RNA-binding protein 26 (RBM26); cd12516"
                     /db_xref="CDD:409938"
     Region          675..>767
                     /region_name="DR0291"
                     /note="Predicted nucleic acid-binding protein DR0291,
                     contains C4-type Zn-ribbon domain [General function
                     prediction only]; COG1579"
                     /db_xref="CDD:441187"
     Region          859..930
                     /region_name="RRM2_RBM26_like"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     RNA-binding protein 26 (RBM26) and similar proteins;
                     cd12258"
                     /db_xref="CDD:409703"
     CDS             1..958
                     /gene="RBM26"
                     /gene_synonym="ARRS2; C13orf10; PPP1R132; PRO1777; SE70-2;
                     ZC3H17"
                     /coded_by="XM_047430535.1:482..3358"
                     /db_xref="GeneID:64062"
                     /db_xref="HGNC:HGNC:20327"
                     /db_xref="MIM:620081"
ORIGIN      
        1 mvskmiienf ealkswlskt lepicdadps alakyvlalv kkdksekelk alcidqldvf
       61 lqketqifve klfdavntks ylpppeqpss gslkveffph qekdikkeei tkeeerekkf
      121 srrlnhsppq sssryrenrs rderkkddrs rkrdydrnpp rrdsyrdryn rrrgrsrsys
      181 rsrsrswske rlrerdrdrs rtrsrsrtrs rerdlvkpky dldrtdplen nytpvssvps
      241 issghypvpt lsstitviap thhgnnttes wsefhedqvd hnsyvrppmp kkrcrdydek
      301 gfcmrgdmcp fdhgsdpvvv edvnlpgmlp fpaqppvveg ppppglpppp piltpppvnl
      361 rppvpppgpl ppslppvtgp ppplpplqps gmdappnsat ssvptvvttg ihhqpppapp
      421 slftadtydt dgynpeapsi tntsrpmyrh rvhaqrpnli gltsgdmdlp prekppnkss
      481 mrivvdsesr krtigsgepg vptkktwfdk pnfnrtnspg fqkkvqfgne ntklelrkvp
      541 pelnniskln ehfsrfgtlv nlqvayngdp egaliqfaty eeakkaisst eavlnnrfik
      601 vywhregstq qlqttspkpl vqqpilpvvk qsvkerlgpv psstiepaea qsassdlpqv
      661 lststgltkt vynpaalkaa qktllvstsa vdnneaqkkk qealklqqdv rkrkqeilek
      721 hietqkmlis kleknktmks edkaeimktl evltknitkl kdevkaaspg rclpksiktk
      781 tqmqkelldt eldlykkmqa geevtelrrk ytelqleaak rgilssgrgr gihsrgrgav
      841 hgrgrgrgrg rgvpghavvd hrpraleisa ftesdredll phfaqygeie dcqiddsslh
      901 avitfktrae aeaaavhgar fkgqdlklaw nkpvtnisav eteevepdee eqreiiia
//
LOCUS       XP_047286492             957 aa            linear   PRI 05-AUG-2025
DEFINITION  RNA-binding protein 26 isoform X45 [Homo sapiens].
ACCESSION   XP_047286492
VERSION     XP_047286492.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430536.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..957
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..957
                     /product="RNA-binding protein 26 isoform X45"
                     /calculated_mol_wt=107677
     Region          11..76
                     /region_name="PWI"
                     /note="PWI domain; pfam01480"
                     /db_xref="CDD:460224"
     Region          <294..314
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Region          531..606
                     /region_name="RRM1_RBM26"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     RNA-binding protein 26 (RBM26); cd12516"
                     /db_xref="CDD:409938"
     Region          675..>767
                     /region_name="DR0291"
                     /note="Predicted nucleic acid-binding protein DR0291,
                     contains C4-type Zn-ribbon domain [General function
                     prediction only]; COG1579"
                     /db_xref="CDD:441187"
     Region          859..930
                     /region_name="RRM2_RBM26_like"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     RNA-binding protein 26 (RBM26) and similar proteins;
                     cd12258"
                     /db_xref="CDD:409703"
     CDS             1..957
                     /gene="RBM26"
                     /gene_synonym="ARRS2; C13orf10; PPP1R132; PRO1777; SE70-2;
                     ZC3H17"
                     /coded_by="XM_047430536.1:482..3355"
                     /db_xref="GeneID:64062"
                     /db_xref="HGNC:HGNC:20327"
                     /db_xref="MIM:620081"
ORIGIN      
        1 mvskmiienf ealkswlskt lepicdadps alakyvlalv kkdksekelk alcidqldvf
       61 lqketqifve klfdavntks ylpppeqpss gslkveffph qekdikkeei tkeeerekkf
      121 srrlnhsppq sssryrenrs rderkkddrs rkrdydrnpp rrdsyrdryn rrrgrsrsys
      181 rsrsrswske rlrerdrdrs rtrsrsrtrs rerdlvkpky dldrtdplen nytpvssvps
      241 issghypvpt lsstitviap thhgnnttes wsefhedqvd hnsyvrppmp kkrcrdydek
      301 gfcmrgdmcp fdhgsdpvvv edvnlpgmlp fpaqppvveg ppppglpppp piltpppvnl
      361 rppvpppgpl ppslppvtgp ppplpplqps gmdappnsat ssvptvvttg ihhqpppapp
      421 slftadtydt dgynpeapsi tntsrpmyrh rvhaqrpnli gltsgdmdlp prekppnkss
      481 mrivvdsesr krtigsgepg vptkktwfdk pnfnrtnspg fqkkvqfgne ntklelrkvp
      541 pelnniskln ehfsrfgtlv nlqvayngdp egaliqfaty eeakkaisst eavlnnrfik
      601 vywhregstq qlqttspkpl vqqpilpvvk qsvkerlgpv psstiepaea qsassdlpqv
      661 lststgltkt vynpaalkaa qktllvstsa vdnneaqkkk qealklqqdv rkrkqeilek
      721 hietqkmlis kleknktmks edkaeimktl evltknitkl kdevkaaspg rclpksiktk
      781 tqmqkelldt eldlykkmqa geevtelrrk ytelqleaak rgilssgrgr gihsrgrgav
      841 hgrgrgrgrg rgvpghavvd hrpraleisa ftesdredll phfaqygeie dcqiddsslh
      901 avitfktrae aeaaavhgar fkgqdlklaw nkpvtnisav eteevepdee ereiiia
//
LOCUS       XP_011533497             737 aa            linear   PRI 05-AUG-2025
DEFINITION  RNA-binding protein 26 isoform X46 [Homo sapiens].
ACCESSION   XP_011533497
VERSION     XP_011533497.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535195.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..737
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..737
                     /product="RNA-binding protein 26 isoform X46"
                     /calculated_mol_wt=81208
     Region          <6..26
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Region          258..333
                     /region_name="RRM1_RBM26"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     RNA-binding protein 26 (RBM26); cd12516"
                     /db_xref="CDD:409938"
     Region          429..>521
                     /region_name="DR0291"
                     /note="Predicted nucleic acid-binding protein DR0291,
                     contains C4-type Zn-ribbon domain [General function
                     prediction only]; COG1579"
                     /db_xref="CDD:441187"
     Region          613..684
                     /region_name="RRM2_RBM26_like"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     RNA-binding protein 26 (RBM26) and similar proteins;
                     cd12258"
                     /db_xref="CDD:409703"
     CDS             1..737
                     /gene="RBM26"
                     /gene_synonym="ARRS2; C13orf10; PPP1R132; PRO1777; SE70-2;
                     ZC3H17"
                     /coded_by="XM_011535195.2:2532..4745"
                     /db_xref="GeneID:64062"
                     /db_xref="HGNC:HGNC:20327"
                     /db_xref="MIM:620081"
ORIGIN      
        1 mpkkrcrdyd ekgfcmrgdm cpfdhgsdpv vvedvnlpgm lpfpaqppvv egppppglpp
       61 pppiltpppv nlrppvpppg plppslppvt ddisyslvlt gpppplpplq psgmdappns
      121 atssvptvvt tgihhqpppa ppslftavfv lpdtydtdgy npeapsitnt srpmyrhrvh
      181 aqrpnliglt sgdmdlppre kppnkssmri vvdsesrkrt igsgepgvpt kktwfdkpnf
      241 nrtnspgfqk kvqfgnentk lelrkvppel nnisklnehf srfgtlvnlq vayngdpega
      301 liqfatyeea kkaissteav lnnrfikvyw hregstqqlq ttspkvmqpl vqqpilpvvk
      361 qsvkerlgpv psstiepaea qsassdlpqn vtklsvkdrl gfvskpsvsa tekvlststg
      421 ltktvynpaa lkaaqktllv stsavdnnea qkkkqealkl qqdvrkrkqe ilekhietqk
      481 mliskleknk tmksedkaei mktlevltkn itklkdevka aspgrclpks iktktqmqke
      541 lldteldlyk kmqageevte lrrkytelql eaakrgilss grgrgihsrg rgavhgrgrg
      601 rgrgrgvpgh avvdhrpral eisaftesdr edllphfaqy geiedcqidd sslhavitfk
      661 traeaeaaav hgarfkgqdl klawnkpvtn isaveteeve pdeeeiipls fhefelngek
      721 srrapgiryf ekfeiav
//
LOCUS       XP_047286493            1124 aa            linear   PRI 05-AUG-2025
DEFINITION  exportin-4 isoform X1 [Homo sapiens].
ACCESSION   XP_047286493
VERSION     XP_047286493.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430537.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 1% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1124
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1124
                     /product="exportin-4 isoform X1"
                     /calculated_mol_wt=127306
     CDS             1..1124
                     /gene="XPO4"
                     /gene_synonym="exp4"
                     /coded_by="XM_047430537.1:183..3557"
                     /db_xref="GeneID:64328"
                     /db_xref="HGNC:HGNC:17796"
                     /db_xref="MIM:611449"
ORIGIN      
        1 mvnneqrqha ehiflsfrks kspfavckhi letskvdyvl fqaataimea vvrewillek
       61 gsieslrtfl ltyvlqrpnl qkyvreqill avavivkrgs ldksidcksi fhevsqliss
      121 gnptvqtlac siltallsef ssssktsnig lsmefhgnck rvfqeedlrq ifmltvevlq
      181 efsrrenlna qmssvfqryl alanqvlswn flppnlgrhy iamfessqnv llkpteswre
      241 tlldsrvmel fftvhrkire dsdmaqdslq claqlaslhg pifpdegsqv dylahfiegl
      301 lntingieie dseavgissi isnlitvfpr nvltaipsel fssfvnclth ltcsfgrsaa
      361 leevldkddm vymeaydkll eswltlvqdd khfhkgfftq havqvfnsyi qchlaapdgt
      421 rnltangvas reeeeiselq eddrdqfsdq lasvgmlgri aaehcipllt slleervtrl
      481 hgqlqrhqqq llaspgsstv dnkmlddlye dihwlilvtg ylladdtqge tplippeime
      541 ysikhssevd inttlqilgs pgekassipg ynrtdsvirl lsailrvsev esrairadlt
      601 hllspqmgkd ivwflkrwak tyllvdekly dqislpfsta fgadtegsqw iigyllqkvi
      661 snlsvwsseq dlandtvqll vtlverrera nlviqcenww nlakqfasrs pplnflsspv
      721 qrtlmkalvl ggfahmdtet kqqywtevlq plqqrflrvi nqenfqqmcq qeevkqeita
      781 tlealcgiae atqidnvail fnflmdfltn ciglmevykn tpetvnliie vfvevahkqi
      841 cylgeskamn lyeacltllq vysknnlgrq ridvtaeeeq yqdlllimel ltnllskefi
      901 dfsdtdevfr ghepgqaanr svsaadvvly gvnlilplms qdllkfptlc nqyyklitfi
      961 ceifpekipq lpedlfkslm yslelgmtsm ssevcqlcle altplaeqca kaqetdsplf
     1021 latrhflklv fdmlvlqkhn temttaagea fytlvclhqa eyselvetll ssqqdpviyq
     1081 rladafnklt asstpptldr kqkmaflksl eefmanvggl lcvk
//
LOCUS       XP_016876193             976 aa            linear   PRI 05-AUG-2025
DEFINITION  exportin-4 isoform X2 [Homo sapiens].
ACCESSION   XP_016876193
VERSION     XP_016876193.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020704.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..976
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..976
                     /product="exportin-4 isoform X2"
                     /calculated_mol_wt=110708
     CDS             1..976
                     /gene="XPO4"
                     /gene_synonym="exp4"
                     /coded_by="XM_017020704.3:118..3048"
                     /db_xref="GeneID:64328"
                     /db_xref="HGNC:HGNC:17796"
                     /db_xref="MIM:611449"
ORIGIN      
        1 mehvlkemvf signfkeedl rqifmltvev lqefsrrenl naqmssvfqr ylalanqvls
       61 wnflppnlgr hyiamfessq nvllkptesw retlldsrvm elfftvhrki redsdmaqds
      121 lqclaqlasl hgpifpdegs qvdylahfie gllntingie iedseavgis siisnlitvf
      181 prnvltaips elfssfvncl thltcsfgrs aaleevldkd dmvymeaydk lleswltlvq
      241 ddkhfhkgff tqhavqvfns yiqchlaapd gtrnltangv asreeeeise lqeddrdqfs
      301 dqlasvgmlg riaaehcipl ltslleervt rlhgqlqrhq qqllaspgss tvdnkmlddl
      361 yedihwlilv tgylladdtq getplippei meysikhsse vdinttlqil gspgekassi
      421 pgynrtdsvi rllsailrvs evesrairad lthllspqmg kdivwflkrw aktyllvdek
      481 lydqislpfs tafgadtegs qwiigyllqk visnlsvwss eqdlandtvq llvtlverre
      541 ranlviqcen wwnlakqfas rspplnflss pvqrtlmkal vlggfahmdt etkqqywtev
      601 lqplqqrflr vinqenfqqm cqqeevkqei tatlealcgi aeatqidnva ilfnflmdfl
      661 tnciglmevy kntpetvnli ievfvevahk qicylgeska mnlyeacltl lqvysknnlg
      721 rqridvtaee eqyqdlllim elltnllske fidfsdtdev frghepgqaa nrsvsaadvv
      781 lygvnlilpl msqdllkfpt lcnqyyklit ficeifpeki pqlpedlfks lmyslelgmt
      841 smssevcqlc lealtplaeq cakaqetdsp lflatrhflk lvfdmlvlqk hntemttaag
      901 eafytlvclh qaeyselvet llssqqdpvi yqrladafnk ltasstpptl drkqkmaflk
      961 sleefmanvg gllcvk
//
LOCUS       XP_011533502             972 aa            linear   PRI 05-AUG-2025
DEFINITION  exportin-4 isoform X3 [Homo sapiens].
ACCESSION   XP_011533502
VERSION     XP_011533502.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535200.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..972
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..972
                     /product="exportin-4 isoform X3"
                     /calculated_mol_wt=110295
     CDS             1..972
                     /gene="XPO4"
                     /gene_synonym="exp4"
                     /coded_by="XM_011535200.3:1833..4751"
                     /db_xref="GeneID:64328"
                     /db_xref="HGNC:HGNC:17796"
                     /db_xref="MIM:611449"
ORIGIN      
        1 mefhgnckrv fqeedlrqif mltvevlqef srrenlnaqm ssvfqrylal anqvlswnfl
       61 ppnlgrhyia mfessqnvll kpteswretl ldsrvmelff tvhrkireds dmaqdslqcl
      121 aqlaslhgpi fpdegsqvdy lahfieglln tingieieds eavgissiis nlitvfprnv
      181 ltaipselfs sfvnclthlt csfgrsaale evldkddmvy meaydklles wltlvqddkh
      241 fhkgfftqha vqvfnsyiqc hlaapdgtrn ltangvasre eeeiselqed drdqfsdqla
      301 svgmlgriaa ehciplltsl leervtrlhg qlqrhqqqll aspgsstvdn kmlddlyedi
      361 hwlilvtgyl laddtqgetp lippeimeys ikhssevdin ttlqilgspg ekassipgyn
      421 rtdsvirlls ailrvseves rairadlthl lspqmgkdiv wflkrwakty llvdeklydq
      481 islpfstafg adtegsqwii gyllqkvisn lsvwsseqdl andtvqllvt lverreranl
      541 viqcenwwnl akqfasrspp lnflsspvqr tlmkalvlgg fahmdtetkq qywtevlqpl
      601 qqrflrvinq enfqqmcqqe evkqeitatl ealcgiaeat qidnvailfn flmdfltnci
      661 glmevykntp etvnliievf vevahkqicy lgeskamnly eacltllqvy sknnlgrqri
      721 dvtaeeeqyq dlllimellt nllskefidf sdtdevfrgh epgqaanrsv saadvvlygv
      781 nlilplmsqd llkfptlcnq yyklitfice ifpekipqlp edlfkslmys lelgmtsmss
      841 evcqlcleal tplaeqcaka qetdsplfla trhflklvfd mlvlqkhnte mttaageafy
      901 tlvclhqaey selvetllss qqdpviyqrl adafnkltas stpptldrkq kmaflkslee
      961 fmanvggllc vk
//
LOCUS       XP_047286494             972 aa            linear   PRI 05-AUG-2025
DEFINITION  exportin-4 isoform X3 [Homo sapiens].
ACCESSION   XP_047286494
VERSION     XP_047286494.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430538.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..972
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..972
                     /product="exportin-4 isoform X3"
                     /calculated_mol_wt=110295
     CDS             1..972
                     /gene="XPO4"
                     /gene_synonym="exp4"
                     /coded_by="XM_047430538.1:2313..5231"
                     /db_xref="GeneID:64328"
                     /db_xref="HGNC:HGNC:17796"
                     /db_xref="MIM:611449"
ORIGIN      
        1 mefhgnckrv fqeedlrqif mltvevlqef srrenlnaqm ssvfqrylal anqvlswnfl
       61 ppnlgrhyia mfessqnvll kpteswretl ldsrvmelff tvhrkireds dmaqdslqcl
      121 aqlaslhgpi fpdegsqvdy lahfieglln tingieieds eavgissiis nlitvfprnv
      181 ltaipselfs sfvnclthlt csfgrsaale evldkddmvy meaydklles wltlvqddkh
      241 fhkgfftqha vqvfnsyiqc hlaapdgtrn ltangvasre eeeiselqed drdqfsdqla
      301 svgmlgriaa ehciplltsl leervtrlhg qlqrhqqqll aspgsstvdn kmlddlyedi
      361 hwlilvtgyl laddtqgetp lippeimeys ikhssevdin ttlqilgspg ekassipgyn
      421 rtdsvirlls ailrvseves rairadlthl lspqmgkdiv wflkrwakty llvdeklydq
      481 islpfstafg adtegsqwii gyllqkvisn lsvwsseqdl andtvqllvt lverreranl
      541 viqcenwwnl akqfasrspp lnflsspvqr tlmkalvlgg fahmdtetkq qywtevlqpl
      601 qqrflrvinq enfqqmcqqe evkqeitatl ealcgiaeat qidnvailfn flmdfltnci
      661 glmevykntp etvnliievf vevahkqicy lgeskamnly eacltllqvy sknnlgrqri
      721 dvtaeeeqyq dlllimellt nllskefidf sdtdevfrgh epgqaanrsv saadvvlygv
      781 nlilplmsqd llkfptlcnq yyklitfice ifpekipqlp edlfkslmys lelgmtsmss
      841 evcqlcleal tplaeqcaka qetdsplfla trhflklvfd mlvlqkhnte mttaageafy
      901 tlvclhqaey selvetllss qqdpviyqrl adafnkltas stpptldrkq kmaflkslee
      961 fmanvggllc vk
//
LOCUS       XP_016876194             972 aa            linear   PRI 05-AUG-2025
DEFINITION  exportin-4 isoform X3 [Homo sapiens].
ACCESSION   XP_016876194
VERSION     XP_016876194.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020705.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..972
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..972
                     /product="exportin-4 isoform X3"
                     /calculated_mol_wt=110295
     CDS             1..972
                     /gene="XPO4"
                     /gene_synonym="exp4"
                     /coded_by="XM_017020705.2:1610..4528"
                     /db_xref="GeneID:64328"
                     /db_xref="HGNC:HGNC:17796"
                     /db_xref="MIM:611449"
ORIGIN      
        1 mefhgnckrv fqeedlrqif mltvevlqef srrenlnaqm ssvfqrylal anqvlswnfl
       61 ppnlgrhyia mfessqnvll kpteswretl ldsrvmelff tvhrkireds dmaqdslqcl
      121 aqlaslhgpi fpdegsqvdy lahfieglln tingieieds eavgissiis nlitvfprnv
      181 ltaipselfs sfvnclthlt csfgrsaale evldkddmvy meaydklles wltlvqddkh
      241 fhkgfftqha vqvfnsyiqc hlaapdgtrn ltangvasre eeeiselqed drdqfsdqla
      301 svgmlgriaa ehciplltsl leervtrlhg qlqrhqqqll aspgsstvdn kmlddlyedi
      361 hwlilvtgyl laddtqgetp lippeimeys ikhssevdin ttlqilgspg ekassipgyn
      421 rtdsvirlls ailrvseves rairadlthl lspqmgkdiv wflkrwakty llvdeklydq
      481 islpfstafg adtegsqwii gyllqkvisn lsvwsseqdl andtvqllvt lverreranl
      541 viqcenwwnl akqfasrspp lnflsspvqr tlmkalvlgg fahmdtetkq qywtevlqpl
      601 qqrflrvinq enfqqmcqqe evkqeitatl ealcgiaeat qidnvailfn flmdfltnci
      661 glmevykntp etvnliievf vevahkqicy lgeskamnly eacltllqvy sknnlgrqri
      721 dvtaeeeqyq dlllimellt nllskefidf sdtdevfrgh epgqaanrsv saadvvlygv
      781 nlilplmsqd llkfptlcnq yyklitfice ifpekipqlp edlfkslmys lelgmtsmss
      841 evcqlcleal tplaeqcaka qetdsplfla trhflklvfd mlvlqkhnte mttaageafy
      901 tlvclhqaey selvetllss qqdpviyqrl adafnkltas stpptldrkq kmaflkslee
      961 fmanvggllc vk
//
LOCUS       XP_047286495             972 aa            linear   PRI 05-AUG-2025
DEFINITION  exportin-4 isoform X3 [Homo sapiens].
ACCESSION   XP_047286495
VERSION     XP_047286495.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430539.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..972
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..972
                     /product="exportin-4 isoform X3"
                     /calculated_mol_wt=110295
     CDS             1..972
                     /gene="XPO4"
                     /gene_synonym="exp4"
                     /coded_by="XM_047430539.1:191..3109"
                     /db_xref="GeneID:64328"
                     /db_xref="HGNC:HGNC:17796"
                     /db_xref="MIM:611449"
ORIGIN      
        1 mefhgnckrv fqeedlrqif mltvevlqef srrenlnaqm ssvfqrylal anqvlswnfl
       61 ppnlgrhyia mfessqnvll kpteswretl ldsrvmelff tvhrkireds dmaqdslqcl
      121 aqlaslhgpi fpdegsqvdy lahfieglln tingieieds eavgissiis nlitvfprnv
      181 ltaipselfs sfvnclthlt csfgrsaale evldkddmvy meaydklles wltlvqddkh
      241 fhkgfftqha vqvfnsyiqc hlaapdgtrn ltangvasre eeeiselqed drdqfsdqla
      301 svgmlgriaa ehciplltsl leervtrlhg qlqrhqqqll aspgsstvdn kmlddlyedi
      361 hwlilvtgyl laddtqgetp lippeimeys ikhssevdin ttlqilgspg ekassipgyn
      421 rtdsvirlls ailrvseves rairadlthl lspqmgkdiv wflkrwakty llvdeklydq
      481 islpfstafg adtegsqwii gyllqkvisn lsvwsseqdl andtvqllvt lverreranl
      541 viqcenwwnl akqfasrspp lnflsspvqr tlmkalvlgg fahmdtetkq qywtevlqpl
      601 qqrflrvinq enfqqmcqqe evkqeitatl ealcgiaeat qidnvailfn flmdfltnci
      661 glmevykntp etvnliievf vevahkqicy lgeskamnly eacltllqvy sknnlgrqri
      721 dvtaeeeqyq dlllimellt nllskefidf sdtdevfrgh epgqaanrsv saadvvlygv
      781 nlilplmsqd llkfptlcnq yyklitfice ifpekipqlp edlfkslmys lelgmtsmss
      841 evcqlcleal tplaeqcaka qetdsplfla trhflklvfd mlvlqkhnte mttaageafy
      901 tlvclhqaey selvetllss qqdpviyqrl adafnkltas stpptldrkq kmaflkslee
      961 fmanvggllc vk
//
LOCUS       XP_047286496             972 aa            linear   PRI 05-AUG-2025
DEFINITION  exportin-4 isoform X3 [Homo sapiens].
ACCESSION   XP_047286496
VERSION     XP_047286496.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430540.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..972
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..972
                     /product="exportin-4 isoform X3"
                     /calculated_mol_wt=110295
     CDS             1..972
                     /gene="XPO4"
                     /gene_synonym="exp4"
                     /coded_by="XM_047430540.1:821..3739"
                     /db_xref="GeneID:64328"
                     /db_xref="HGNC:HGNC:17796"
                     /db_xref="MIM:611449"
ORIGIN      
        1 mefhgnckrv fqeedlrqif mltvevlqef srrenlnaqm ssvfqrylal anqvlswnfl
       61 ppnlgrhyia mfessqnvll kpteswretl ldsrvmelff tvhrkireds dmaqdslqcl
      121 aqlaslhgpi fpdegsqvdy lahfieglln tingieieds eavgissiis nlitvfprnv
      181 ltaipselfs sfvnclthlt csfgrsaale evldkddmvy meaydklles wltlvqddkh
      241 fhkgfftqha vqvfnsyiqc hlaapdgtrn ltangvasre eeeiselqed drdqfsdqla
      301 svgmlgriaa ehciplltsl leervtrlhg qlqrhqqqll aspgsstvdn kmlddlyedi
      361 hwlilvtgyl laddtqgetp lippeimeys ikhssevdin ttlqilgspg ekassipgyn
      421 rtdsvirlls ailrvseves rairadlthl lspqmgkdiv wflkrwakty llvdeklydq
      481 islpfstafg adtegsqwii gyllqkvisn lsvwsseqdl andtvqllvt lverreranl
      541 viqcenwwnl akqfasrspp lnflsspvqr tlmkalvlgg fahmdtetkq qywtevlqpl
      601 qqrflrvinq enfqqmcqqe evkqeitatl ealcgiaeat qidnvailfn flmdfltnci
      661 glmevykntp etvnliievf vevahkqicy lgeskamnly eacltllqvy sknnlgrqri
      721 dvtaeeeqyq dlllimellt nllskefidf sdtdevfrgh epgqaanrsv saadvvlygv
      781 nlilplmsqd llkfptlcnq yyklitfice ifpekipqlp edlfkslmys lelgmtsmss
      841 evcqlcleal tplaeqcaka qetdsplfla trhflklvfd mlvlqkhnte mttaageafy
      901 tlvclhqaey selvetllss qqdpviyqrl adafnkltas stpptldrkq kmaflkslee
      961 fmanvggllc vk
//
LOCUS       XP_024305162            1077 aa            linear   PRI 05-AUG-2025
DEFINITION  exportin-4 isoform X4 [Homo sapiens].
ACCESSION   XP_024305162
VERSION     XP_024305162.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449394.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1077
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1077
                     /product="exportin-4 isoform X4"
                     /calculated_mol_wt=121889
     CDS             1..1077
                     /gene="XPO4"
                     /gene_synonym="exp4"
                     /coded_by="XM_024449394.2:111..3344"
                     /db_xref="GeneID:64328"
                     /db_xref="HGNC:HGNC:17796"
                     /db_xref="MIM:611449"
ORIGIN      
        1 meavvrewil lekgsieslr tflltyvlqr pnlqkyvreq illavavivk rgsldksidc
       61 ksifhevsql issgnptvqt lacsiltall sefsssskts niglsmefhg nckrvfqeed
      121 lrqifmltve vlqefsrren lnaqmssvfq rylalanqvl swnflppnlg rhyiamfess
      181 qnvllkptes wretlldsrv melfftvhrk iredsdmaqd slqclaqlas lhgpifpdeg
      241 sqvdylahfi egllntingi eiedseavgi ssiisnlitv fprnvltaip selfssfvnc
      301 lthltcsfgr saaleevldk ddmvymeayd klleswltlv qddkhfhkgf ftqhavqvfn
      361 syiqchlaap dgtrnltang vasreeeeis elqeddrdqf sdqlasvgml griaaehcip
      421 lltslleerv trlhgqlqrh qqqllaspgs stvdnkmldd lyedihwlil vtgylladdt
      481 qgetplippe imeysikhss evdinttlqi lgspgekass ipgynrtdsv irllsailrv
      541 sevesraira dlthllspqm gkdivwflkr waktyllvde klydqislpf stafgadteg
      601 sqwiigyllq kvisnlsvws seqdlandtv qllvtlverr eranlviqce nwwnlakqfa
      661 srspplnfls spvqrtlmka lvlggfahmd tetkqqywte vlqplqqrfl rvinqenfqq
      721 mcqqeevkqe itatlealcg iaeatqidnv ailfnflmdf ltnciglmev ykntpetvnl
      781 iievfvevah kqicylgesk amnlyeaclt llqvysknnl grqridvtae eeqyqdllli
      841 melltnllsk efidfsdtde vfrghepgqa anrsvsaadv vlygvnlilp lmsqdllkfp
      901 tlcnqyykli tficeifpek ipqlpedlfk slmyslelgm tsmssevcql clealtplae
      961 qcakaqetds plflatrhfl klvfdmlvlq khntemttaa geafytlvcl hqaeyselve
     1021 tllssqqdpv iyqrladafn kltasstppt ldrkqkmafl ksleefmanv ggllcvk
//
LOCUS       XP_016876195             875 aa            linear   PRI 05-AUG-2025
DEFINITION  exportin-4 isoform X5 [Homo sapiens].
ACCESSION   XP_016876195
VERSION     XP_016876195.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020706.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..875
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..875
                     /product="exportin-4 isoform X5"
                     /calculated_mol_wt=98651
     CDS             1..875
                     /gene="XPO4"
                     /gene_synonym="exp4"
                     /coded_by="XM_017020706.3:1030..3657"
                     /db_xref="GeneID:64328"
                     /db_xref="HGNC:HGNC:17796"
                     /db_xref="MIM:611449"
ORIGIN      
        1 mdgkvhrkir edsdmaqdsl qclaqlaslh gpifpdegsq vdylahfieg llntingiei
       61 edseavgiss iisnlitvfp rnvltaipse lfssfvnclt hltcsfgrsa aleevldkdd
      121 mvymeaydkl leswltlvqd dkhfhkgfft qhavqvfnsy iqchlaapdg trnltangva
      181 sreeeeisel qeddrdqfsd qlasvgmlgr iaaehcipll tslleervtr lhgqlqrhqq
      241 qllaspgsst vdnkmlddly edihwlilvt gylladdtqg etplippeim eysikhssev
      301 dinttlqilg spgekassip gynrtdsvir llsailrvse vesrairadl thllspqmgk
      361 divwflkrwa ktyllvdekl ydqislpfst afgadtegsq wiigyllqkv isnlsvwsse
      421 qdlandtvql lvtlverrer anlviqcenw wnlakqfasr spplnflssp vqrtlmkalv
      481 lggfahmdte tkqqywtevl qplqqrflrv inqenfqqmc qqeevkqeit atlealcgia
      541 eatqidnvai lfnflmdflt nciglmevyk ntpetvnlii evfvevahkq icylgeskam
      601 nlyeacltll qvysknnlgr qridvtaeee qyqdlllime lltnllskef idfsdtdevf
      661 rghepgqaan rsvsaadvvl ygvnlilplm sqdllkfptl cnqyyklitf iceifpekip
      721 qlpedlfksl myslelgmts mssevcqlcl ealtplaeqc akaqetdspl flatrhflkl
      781 vfdmlvlqkh ntemttaage afytlvclhq aeyselvetl lssqqdpviy qrladafnkl
      841 tasstpptld rkqkmaflks leefmanvgg llcvk
//
LOCUS       XP_005266561             861 aa            linear   PRI 05-AUG-2025
DEFINITION  exportin-4 isoform X6 [Homo sapiens].
ACCESSION   XP_005266561
VERSION     XP_005266561.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266504.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..861
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..861
                     /product="exportin-4 isoform X6"
                     /calculated_mol_wt=96983
     CDS             1..861
                     /gene="XPO4"
                     /gene_synonym="exp4"
                     /coded_by="XM_005266504.5:439..3024"
                     /db_xref="GeneID:64328"
                     /db_xref="HGNC:HGNC:17796"
                     /db_xref="MIM:611449"
ORIGIN      
        1 maqdslqcla qlaslhgpif pdegsqvdyl ahfiegllnt ingieiedse avgissiisn
       61 litvfprnvl taipselfss fvnclthltc sfgrsaalee vldkddmvym eaydkllesw
      121 ltlvqddkhf hkgfftqhav qvfnsyiqch laapdgtrnl tangvasree eeiselqedd
      181 rdqfsdqlas vgmlgriaae hciplltsll eervtrlhgq lqrhqqqlla spgsstvdnk
      241 mlddlyedih wlilvtgyll addtqgetpl ippeimeysi khssevdint tlqilgspge
      301 kassipgynr tdsvirllsa ilrvsevesr airadlthll spqmgkdivw flkrwaktyl
      361 lvdeklydqi slpfstafga dtegsqwiig yllqkvisnl svwsseqdla ndtvqllvtl
      421 verreranlv iqcenwwnla kqfasrsppl nflsspvqrt lmkalvlggf ahmdtetkqq
      481 ywtevlqplq qrflrvinqe nfqqmcqqee vkqeitatle alcgiaeatq idnvailfnf
      541 lmdfltncig lmevykntpe tvnliievfv evahkqicyl geskamnlye acltllqvys
      601 knnlgrqrid vtaeeeqyqd lllimelltn llskefidfs dtdevfrghe pgqaanrsvs
      661 aadvvlygvn lilplmsqdl lkfptlcnqy yklitficei fpekipqlpe dlfkslmysl
      721 elgmtsmsse vcqlclealt plaeqcakaq etdsplflat rhflklvfdm lvlqkhntem
      781 ttaageafyt lvclhqaeys elvetllssq qdpviyqrla dafnkltass tpptldrkqk
      841 maflksleef manvggllcv k
//
LOCUS       XP_047286497             562 aa            linear   PRI 05-AUG-2025
DEFINITION  exportin-4 isoform X7 [Homo sapiens].
ACCESSION   XP_047286497
VERSION     XP_047286497.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430541.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..562
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..562
                     /product="exportin-4 isoform X7"
                     /calculated_mol_wt=63320
     CDS             1..562
                     /gene="XPO4"
                     /gene_synonym="exp4"
                     /coded_by="XM_047430541.1:37..1725"
                     /db_xref="GeneID:64328"
                     /db_xref="HGNC:HGNC:17796"
                     /db_xref="MIM:611449"
ORIGIN      
        1 mmaaalgppe viaqlenaak vlmappsmvn neqrqhaehi flsfrksksp favckhilet
       61 skvdyvlfqa ataimeavvr ewillekgsi eslrtfllty vlqrpnlqky vreqillava
      121 vivkrgsldk sidcksifhe vsqlissgnp tvqtlacsil tallsefsss sktsniglsm
      181 efhgnckrvf qeedlrqifm ltvevlqefs rrenlnaqms svfqrylala nqvlswnflp
      241 pnlgrhyiam fessqnvllk pteswretll dsrvmelfft vhrkiredsd maqdslqcla
      301 qlaslhgpif pdegsqvdyl ahfiegllnt ingieiedse avgissiisn litvfprnvl
      361 taipselfss fvnclthltc sfgrsaalee vldkddmvym eaydkllesw ltlvqddkhf
      421 hkgfftqhav qvfnsyiqch laapdgtrnl tangvasree eeiselqedd rdqfsdqlas
      481 vgmlgriaae hciplltsll eervtrlhgq lqrhqqqlla spgsstvdnk mlddlyedih
      541 wlilvtgccl pfsefqklnl eq
//
LOCUS       XP_011519408            7041 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat transmembrane protein CCDC168 isoform X1 [Homo
            sapiens].
ACCESSION   XP_011519408
VERSION     XP_011519408.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521106.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..7041
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..7041
                     /product="leucine-rich repeat transmembrane protein
                     CCDC168 isoform X1"
                     /calculated_mol_wt=797176
     Region          3513..3691
                     /region_name="CCDC168_N"
                     /note="Coiled-coil domain-containing protein 168;
                     pfam15804"
                     /db_xref="CDD:464883"
     Region          3619..3821
                     /region_name="CCDC168_N"
                     /note="Coiled-coil domain-containing protein 168;
                     pfam15804"
                     /db_xref="CDD:464883"
     Region          3877..4054
                     /region_name="CCDC168_N"
                     /note="Coiled-coil domain-containing protein 168;
                     pfam15804"
                     /db_xref="CDD:464883"
     Region          4000..4171
                     /region_name="CCDC168_N"
                     /note="Coiled-coil domain-containing protein 168;
                     pfam15804"
                     /db_xref="CDD:464883"
     Region          4114..>4323
                     /region_name="CCDC168_N"
                     /note="Coiled-coil domain-containing protein 168;
                     pfam15804"
                     /db_xref="CDD:464883"
     Region          4297..4533
                     /region_name="CCDC168_N"
                     /note="Coiled-coil domain-containing protein 168;
                     pfam15804"
                     /db_xref="CDD:464883"
     Region          4591..4794
                     /region_name="CCDC168_N"
                     /note="Coiled-coil domain-containing protein 168;
                     pfam15804"
                     /db_xref="CDD:464883"
     Region          4840..5021
                     /region_name="CCDC168_N"
                     /note="Coiled-coil domain-containing protein 168;
                     pfam15804"
                     /db_xref="CDD:464883"
     Region          4972..5170
                     /region_name="CCDC168_N"
                     /note="Coiled-coil domain-containing protein 168;
                     pfam15804"
                     /db_xref="CDD:464883"
     Region          5100..5271
                     /region_name="CCDC168_N"
                     /note="Coiled-coil domain-containing protein 168;
                     pfam15804"
                     /db_xref="CDD:464883"
     Region          5326..5518
                     /region_name="CCDC168_N"
                     /note="Coiled-coil domain-containing protein 168;
                     pfam15804"
                     /db_xref="CDD:464883"
     Region          5473..>5605
                     /region_name="CCDC168_N"
                     /note="Coiled-coil domain-containing protein 168;
                     pfam15804"
                     /db_xref="CDD:464883"
     CDS             1..7041
                     /gene="LRTM3"
                     /gene_synonym="C13orf40; CCDC168"
                     /coded_by="XM_011521106.2:141..21266"
                     /db_xref="GeneID:643677"
                     /db_xref="HGNC:HGNC:26851"
ORIGIN      
        1 mskqyysfkk gvgsglednt fmtlwdfles wiiqndwvai ffiillgiif eiilmkacas
       61 fwkkptlpek gssdvqeted scpksrklap enwsvinsss gervgtflek ritssltsee
      121 kecnfedril fsreilwsgt sesedqvsps seshvpssng issslplfys eveetclsht
      181 ehpdreyeti qfsskklfsm mktnknknsg fssdlsfsas rftvenedld vapcplahlf
      241 lsrdqvrlle envrnqipsk pktklgsrtt yqcsrsqesl nqnqpsvgmv isvqaqdsfp
      301 gqnafqnqgl yevqftsqaq yinhnqesik sqpeskasnf aqpedvmkkp fssstqdsfq
      361 sqdldrnqhf vevpsiveak ysvkglesde hlvtedmpql rsvkaqgqqq ivsselnqds
      421 vyssvpllst ikgqknrrkt pdsksklsln vpslkakktp tsqvfqitvc htlknrnelg
      481 cknntekkel herkdisdia lhlisvskli lpyvknysrk qlvkvmpgli kcghflqkqn
      541 kspdtekiny agpleetgis ditkkekeyd kenkrlknis pkmlpqleqs fmvntvqlka
      601 pcllvetngk skeslkdsit qakgigitef hvlnskkpfd lhipkhktsl eeaiskpmqk
      661 lvsspemesn nrmkiqedlq ssenshlqls ngeelptstp ktqrcfpren tqkqkdflel
      721 vlelsnvgll ispgskmhks seeleaikiq vntesvnlke skplilnvte dsdlreseel
      781 ecntgsnitn mhqdketsda fhsatyttis qlpdtethsi skakadtlri irlshsaskq
      841 eklpdeketq naeyidksct fkkpqqcdrk eqekeansel tqgfrfsihl kqkpkyvkfq
      901 meqissgssk apnkeqevqp qtlstqtile nspcpmmdpf qvekvkqstd rptdresagd
      961 pknpltmpen lpvgelliet teysvpfggn lqkttdshia eekedvkryl pavalgsfnn
     1021 hlltlpyfkr qeikkklset ksvlsvkyvi mkvkkpaisl mpyinicgts nhrkkmggnf
     1081 eiiikqilqd kiaagmllnv iyppmsilpn trmysrlnae nhshiklvqe esqiereeky
     1141 pyfinegnes qntldaklqd evkgvketlp kavlhdscnl gldahlekei ktekemhqpi
     1201 pftetiiesv vspimelsha envkstqktq tdckctadse tpspisgksl igdplnqtre
     1261 syipsngsdt remgycfaee kteipkdlpa tspetfnyct pvlscskvmk krvtfaltts
     1321 takpkcvntk avkpsisetv svtshrkkse ldfktkfkki nqtkglvpec lntlcspmhs
     1381 rlqrefclpa sqlkqgetad ktytdvfakn sishdreekl qdgkeeehkv lleaapqlsq
     1441 hlgseagqmk eihlesdpvl ncltlelhin gqrlqhqtgf eqttletslq mgpleaeelq
     1501 kanetendik vlggpkippp kalqalensd glilnayqkd nelvksdeel nqpgstniqv
     1561 qpqthftqti lkstscptld qfpfekvesh vrfsplksge akvdeiifya reggissdss
     1621 hqkeqaggte kketaifgsc mpalstpktt rnlkqfsdmk tlvnpkcgii kakkpsisym
     1681 lniragagpk rrkelscnlt tkmkelhqgk kgvdetyafl tmtpdinkys kvetekdtlr
     1741 ekrlsstqvk qdtsphedsi tsrdiketll qdeeqeerkq eallkvipqh lqhfmfrsgq
     1801 gkdldfhkle nqgsrkilfv tkqdvpqqlq paepiqreet kkclqtqngt ictvnskllp
     1861 lksedsvnge vltgaikrgv ptdrkcmgeq hnsgkgekae fnkdlqatvl elqksphgge
     1921 aqkanltdme sgssnamnmn vqheredkni qkmltesvpc ysqhlrfsth qmkdpdpcks
     1981 gsepkspegr swnlshivqk tkqethfret vlepisgymm kqsphmqegi kcmeglktsf
     2041 pktgkskigs iprdtpwden prrkwdssis ektawnqknl qtvlkpldfs slmsseyesr
     2101 sytlefigkk smspkcvtlk akqlrilqlf niirystenh rkkkqhrfky kmkgkqwyts
     2161 igeallsate yaksttsksm idkllyntaa rcilsnrtrr qnldghitee keevqenvaa
     2221 iflglldffm pvlsdsknqr ntaqlsekei ifnakcltmk ekkssisqih kinrestrkh
     2281 rkkcksylkt vsnrkcqenh ghiteeeeev qenspatflg pldffmpvls dsknqintiq
     2341 lserkiilnp kcltmkekkp pisqihkisg qfttkhrkkl esnlktklka mwqgenvadt
     2401 fpnttsftpd ssdikrqsgf qteidmrisg lshtqptqie slaegiarys dpidkrrtsn
     2461 lvkgaklhdr esgeekqehl temdpfyaen fmantylrkd rhlgksedvl lgetffsksq
     2521 iykgnseknv kieknkngke slkvglarme ksdncaelse atddaisnky dkqnighsvl
     2581 kenafcnlaa ivpdsvgrhs paseemkrqn grlkmadrss pqgrplqakq savsqspdta
     2641 gyavvsnnke qkqnfkaqkt eaevdlidqe akinvaeefn pesvffskih plqienkkef
     2701 ktadwktrad pktfalpkkq qelcvsgtiw sypnpytsis pkiirhkdka ktadvestmh
     2761 tkqiklkakr itvsqlleyg tasnkkelrg niqqqksfql sknavhrvlk avydsgycvs
     2821 sikkltevkm ekdkpkdrtc ilpqpklekp lkemqrslsg ctdmssilrk qeqdirekeq
     2881 khqsisedis qyyigplris sqqinyssfd aprirtdeel efliaqrake kdvgiakhsv
     2941 sipweregsk rldiplnskg qniffteldt sqqktcqeqe llkqedismt nlgsmacpim
     3001 eplhlentgk vteeedvyin rkisshvlgk eglketdifv gskgqkflct nsevqhkvpa
     3061 eqkeqvnpdh vpesildses flskdplhlk qavntarken vtisesfnen lwgkeqskld
     3121 itlksnrqkm dfskklrmkh lsnyyqnken ilesvlpcil hqlyienpkk egsaeeimss
     3181 kvlspmveka shevgipvdq ppcsegihln ikgrkehpqe stheafpasv shslmdvlqi
     3241 kspkvkkalk ainslgylts ntkgigllfp rqaekeekyt ykalpkpash sktdlfqfna
     3301 smqqekldam diphydylts qtreavkqmd vivgytqnsk krqdllktgq kwqylpisye
     3361 nfwehiscpq kypcllqhlm pqekealseg gnlssrtpgl dlfsadqlst itknrlewiv
     3421 plisprqmkk qdsmlplgsy hktikyasll fpkgmkssdg vqvfdlisnn sspklrlgkk
     3481 ietqkanekv qkevclpitl hslsasmpil qeskgqkdsv eqvirkgvic hkrrtskwkk
     3541 svfshilnts dcgassnrle mqwnmtdkmv nvkhrmseid lvaakicesi lslphfklnk
     3601 etidgvissn vkstkqhisq gkndrvkamd mkrikspnii lkprksslsh ilsikefpll
     3661 ldiikqegkm qegkgkssmk ltnlctslps lshsnsnsrt kagkdksgtl kgclpplklq
     3721 assnarrvss aesinrdsls nvieskcfpq kkkedreniv dvkdvmglkc itlkgkkslf
     3781 rhllhgkepq rsnkklekmt qedesnlnvv qnklcasils pphlewnpri kevymrgitr
     3841 fclssstqqe lsdtmekceq piddslssie kakhmpqkdk drvekaleki mhskrialev
     3901 kqpsifqele lnikekggki qedkeveiws kpfasisflp yskvgtiege eamrikmrss
     3961 fsqpnlqess dtektayekc isdnisnsvk kalesilqke qrqkmekira lkkmkssisq
     4021 giqldikeqe kriehikgep svlltnacas ipspshlqld trrekaeyvt eitryylpel
     4081 shqksseage kadgvaskgd itikvqkakd ymqqkeddev kisakkdimh pedkglkakk
     4141 alsqdlplnt kepgkmdqea qeqgkedreg eeqgkedrrg agqekvdred keqgkmdhev
     4201 eeqqkadgvg ieqgkmdgdk neqervlfly lpsnsslthy ildtriegee dqqgiirpgi
     4261 lqprhqksse tgkkangvps egdsasevqk akdymqqkee devkisaekd lmhpedkdlk
     4321 gkkalsqnlp lnpkepgkrd gegqeqgked gegeeqgnrd geteeqqqad gvgteqekrd
     4381 ghkskqetvl flhlpsessl tcyelntrke geedlqgiik satlqlrqqk sfdagkiaht
     4441 ksfgvdssnd vktvqeykpq kevdrgktvs vdyimqpegt ifeaeqlslp htlnipgssg
     4501 sktrevltni keklrhvqer kseldvflti pslshckldk rtagkkeeqg vtrsflppsw
     4561 hmessdtgkl kytlsylndi tgdsnrtkym aqiqkdkani seksvmhpey iavkaekspl
     4621 shilktkelq vnisqqgeka qegeveivvl lsktcpfvts safleldsik eeegepritr
     4681 sfmphleiqe slpsrqtapt kpteslvkke kqllpqkedr vqtvsmhglm hpngavfkak
     4741 tsappqvfsi tehsplskrk epqwgmkera gqkqdrtgrp hviltkthpf mpslshhrfs
     4801 psqpklpiss gagksrlans negisshkvi lkanqqmpyk eakdrvkieg regrilpkri
     4861 hlraealpla llcngknysl hieeqgegvq eskkepgvvp rksasfpppp fylncdtrrn
     4921 ekegtlgktq fsfpplkiqd ssdsgkkayt eslhgytlsn skgpvqptaq geekgglrid
     4981 medkmlpkct dlkakqllls dilntkklqw kskeqkrkiq edknkqvkgl psintslltp
     5041 pylkfdtteg qenviriakv slpqsrskes sdagriacpe athgelssdv kqlkahllqk
     5101 eekdrekvad mtsvldpnkm ylkakkspvl hthsfsdlqw ktreqeeekv qkvksgpgvm
     5161 lskspsrssp lhlnvntgfq eesipiltrp sfplvklqvs pdteggtcir piagdiliyl
     5221 qkgkhvsqnk eeddvqivsi lifpkhqeek vqecegepgv vltkstslps lsqleldket
     5281 hlgnemlrlk rpilrrishi getvhresvv gdipkdvkne kqhipqkeer nqkkiidmrg
     5341 tditlkskks prscmlhrte lhvniggqgr kehegqdkpp gmiqrkmcil fskplpsnlk
     5401 lerathadee rlggktsfvl plmpsalpdt ektadaears gdvrkgkphr sqkenrhevk
     5461 tidmrfrihc qearispmsh ilnakelvln inklekkvhk dkdeacvvls rtflsipsap
     5521 plyldsgnkt dkdtpgitgs scpqrtlhvp sntqkitnrd svegvdknvv kqaeqyvprp
     5581 eaeqqltsnf misvqqrnqp srvrseedln qlvlnsrded iyftgfgtir sgkrpewlft
     5641 gkkaqpvkyk tetltaflsy ptmdatkmgg leedteimdn lnhkispkas vslirkiske
     5701 lyvtlgtpan skgfsvsery ahqqetsskv spelagsckf dkpkedgqsn driskmfspk
     5761 vlapqtkgsl kkisivtnwn apqnieeqdi vmkkqvirrc ehghktrtnt ilskfplqsg
     5821 kqktpsetdv dkkttahlsl qmlpgihmdm teidpakggr kqalliseqe egvleflpks
     5881 lfppwtfqfq sgdleekhqt dantninleq kklemdndst vnqkegklki gtnralhlqe
     5941 ektemhkart anlekergrm dtsssahphl lslkaeesqm ktqvithren srlimqkqkk
     6001 eleasnakqs iqlqklfqrn vldsfysyvp lspkrkdqkg rltirdlkre lstkyltmki
     6061 qnhpipqmln itgrgtpsnr kkleydvklk niaswskdvs gifirslsis imrsphtdpk
     6121 tnlerekric lpkfqekspn tsemskrdtl tivkgeqnft ntvpqdpqpf avdkqqmqkl
     6181 pnvkseanlr semnkkylka qtkerivpeh dvsriikkpd lriieqeeki lkriltptec
     6241 psmledpklp kqrdqsepvw dmttqkvqqq kafpgtvpip pqvkssevki vadstnaehl
     6301 lpiceatkai sesqvknmiq dkvssdkldn iqaykpddlk sppfpegpdt istaiypktq
     6361 hkslleqftp keknkltshl eskaleiqln lipemarksl qmfnfypkgt iskdnswrfy
     6421 srhktmnfms legtdtiepn skhkhqkdsp lasnmktliv dvssdseeti tklqsinkle
     6481 ngtsavtsas emllphtlqn hsvkekgkll mhfsvktlei qmkafprivr esyamtsahe
     6541 rkkplsncih pgftgpkrqn rilllseeks lhqidldlqy kylrfllglp vgstfpkpnv
     6601 lpkhsklnti avcknvnagg qsgslsidte lleqhisfkk qsphenssli rkfpqptlvc
     6661 asdrdlhspr kkdtqvlses efhvtpeknk qyhvwfqern tcesvdlrtq rnatgsavsc
     6721 etqisedfvd iqtdiespad ldecsclevs eseecvflea nsylsqesen ilfelqtgip
     6781 lenvykittd lksfysedsg shctrecrke tliitppsck shksrkyrss skmkspdwlc
     6841 hsssntaeiq srsssvsfse ekiswttksr tsyssaplte snikshlakn qgkshrhpes
     6901 qerkkarsdl frknsshwdh dyscthskgk rdrkkrvydy eserldcfqs khksaskphh
     6961 ddinfyserk qnrpfffacv padslevipk tirwtippet lrkrnfripl vakissswni
     7021 wssskkllgs lsgslttvfh s
//
LOCUS       XP_024305166             189 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein C13orf42 isoform X1 [Homo sapiens].
ACCESSION   XP_024305166
VERSION     XP_024305166.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449398.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..189
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..189
                     /product="uncharacterized protein C13orf42 isoform X1"
                     /calculated_mol_wt=21755
     CDS             1..189
                     /gene="C13orf42"
                     /gene_synonym="LINC00371; LINC00372"
                     /coded_by="XM_024449398.2:116..685"
                     /db_xref="GeneID:647166"
                     /db_xref="HGNC:HGNC:42693"
ORIGIN      
        1 mekatpkkys qfsadvaeai affdsiiael dterrpraae aslpnedvdf dvatssrehs
       61 lhsnwilrap rrhsediaah tvhtvdgqfr rstehrtvgt qrrlerhpiy lpkavegafn
      121 twkfkpkack kdlgssrqil fnfsgedmew daelfalepq lspgedyyet enpkgqwllr
      181 erlwertvp
//
LOCUS       XP_047286500             424 aa            linear   PRI 05-AUG-2025
DEFINITION  serpin E3 isoform X1 [Homo sapiens].
ACCESSION   XP_047286500
VERSION     XP_047286500.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430544.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..424
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..424
                     /product="serpin E3 isoform X1"
                     /calculated_mol_wt=46832
     Region          18..400
                     /region_name="serpinE3"
                     /note="serpin family E member 3; cd19574"
                     /db_xref="CDD:381040"
     Site            355..380
                     /site_type="other"
                     /note="reactive center loop (RCL)"
                     /db_xref="CDD:381040"
     CDS             1..424
                     /gene="SERPINE3"
                     /coded_by="XM_047430544.1:149..1423"
                     /db_xref="GeneID:647174"
                     /db_xref="HGNC:HGNC:24774"
                     /db_xref="MIM:620989"
ORIGIN      
        1 mppflitlfl fhscclrang hlregmtllk tefalhlyqs vaacrnetnf vispagvslp
       61 leilqfgaeg stgqqladal gytvhdkrvk dflhavyatl ptssqgteme lacslfvqvg
      121 tplspcfveh vswwanssle padlsepnst aiqtsegasr etagggpseg pggwpweqvs
      181 aafaqlvlvs tmsfqgtwrk rfsstdtqil pftcayglvl qvpmmhqtte vnygqfqdta
      241 ghqvgvlelp ylgsavslfl vlprdkdtpl shiephltas tihlwttslr rarmdvflpr
      301 friqnqfnlk silnswgvtd lfdplkanlk gisgqdgfyv seaihkakie vleegtkasg
      361 atallllkrs ripifkadrp fiyflrepnt gitvffdriq iiyqclssnk gsfvhyplkn
      421 khsf
//
LOCUS       XP_047286501             424 aa            linear   PRI 05-AUG-2025
DEFINITION  serpin E3 isoform X1 [Homo sapiens].
ACCESSION   XP_047286501
VERSION     XP_047286501.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430545.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..424
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..424
                     /product="serpin E3 isoform X1"
                     /calculated_mol_wt=46832
     Region          18..400
                     /region_name="serpinE3"
                     /note="serpin family E member 3; cd19574"
                     /db_xref="CDD:381040"
     Site            355..380
                     /site_type="other"
                     /note="reactive center loop (RCL)"
                     /db_xref="CDD:381040"
     CDS             1..424
                     /gene="SERPINE3"
                     /coded_by="XM_047430545.1:362..1636"
                     /db_xref="GeneID:647174"
                     /db_xref="HGNC:HGNC:24774"
                     /db_xref="MIM:620989"
ORIGIN      
        1 mppflitlfl fhscclrang hlregmtllk tefalhlyqs vaacrnetnf vispagvslp
       61 leilqfgaeg stgqqladal gytvhdkrvk dflhavyatl ptssqgteme lacslfvqvg
      121 tplspcfveh vswwanssle padlsepnst aiqtsegasr etagggpseg pggwpweqvs
      181 aafaqlvlvs tmsfqgtwrk rfsstdtqil pftcayglvl qvpmmhqtte vnygqfqdta
      241 ghqvgvlelp ylgsavslfl vlprdkdtpl shiephltas tihlwttslr rarmdvflpr
      301 friqnqfnlk silnswgvtd lfdplkanlk gisgqdgfyv seaihkakie vleegtkasg
      361 atallllkrs ripifkadrp fiyflrepnt gitvffdriq iiyqclssnk gsfvhyplkn
      421 khsf
//
LOCUS       XP_011533146             406 aa            linear   PRI 05-AUG-2025
DEFINITION  regulator of nonsense transcripts 3A isoform X1 [Homo sapiens].
ACCESSION   XP_011533146
VERSION     XP_011533146.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534844.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..406
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..406
                     /product="regulator of nonsense transcripts 3A isoform X1"
                     /calculated_mol_wt=46559
     Region          66..150
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:473069"
     Region          220..>403
                     /region_name="PRK12678"
                     /note="transcription termination factor Rho; Provisional"
                     /db_xref="CDD:237171"
     CDS             1..406
                     /gene="UPF3A"
                     /gene_synonym="HUPF3A; RENT3A; UPF3"
                     /coded_by="XM_011534844.2:40..1260"
                     /db_xref="GeneID:65110"
                     /db_xref="HGNC:HGNC:20332"
                     /db_xref="MIM:605530"
ORIGIN      
        1 mrsekegagg lraavaargp sgreklsale vqfhrdsqqq eaetpptsss gcgggagkpr
       61 eekrtalskv virrlppglt keqleeqlrp lpahdyfeff aadlslyphl ysrayinfrn
      121 pddillfrdr fdgyifldsk arrttplley iknrklekqr ireekreerr rrelekkrlr
      181 eeekrrrree erckkketdk qkkiaekevr ikllkkpekg eepttekpke rgeeidtggg
      241 kqescapgav vkarpmegsl eepqetshsg sdkehrdver sqeqeseaqr yhvddgrrhr
      301 ahheperlsr rsedeqrwgk gpgqdrgkkg sqdsgapgea merlgraqrc ddspaprker
      361 lankdrpalq lydpgarfra recggnrric kaegsgtgpe kreeae
//
LOCUS       XP_011533147             346 aa            linear   PRI 05-AUG-2025
DEFINITION  regulator of nonsense transcripts 3A isoform X2 [Homo sapiens].
ACCESSION   XP_011533147
VERSION     XP_011533147.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534845.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..346
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..346
                     /product="regulator of nonsense transcripts 3A isoform X2"
                     /calculated_mol_wt=39939
     Region          <10..95
                     /region_name="Smg4_UPF3"
                     /note="Smg-4/UPF3 family; pfam03467"
                     /db_xref="CDD:460932"
     Region          160..>343
                     /region_name="PRK12678"
                     /note="transcription termination factor Rho; Provisional"
                     /db_xref="CDD:237171"
     CDS             1..346
                     /gene="UPF3A"
                     /gene_synonym="HUPF3A; RENT3A; UPF3"
                     /coded_by="XM_011534845.3:378..1418"
                     /db_xref="GeneID:65110"
                     /db_xref="HGNC:HGNC:20332"
                     /db_xref="MIM:605530"
ORIGIN      
        1 masgtcfllk gleypavvef apfqkiakkk lrkkdaktgs ieddpeykkf letycveeek
       61 tsanpetllg emeaktreli arrttplley iknrklekqr ireekreerr rrelekkrlr
      121 eeekrrrree erckkketdk qkkiaekevr ikllkkpekg eepttekpke rgeeidtggg
      181 kqescapgav vkarpmegsl eepqetshsg sdkehrdver sqeqeseaqr yhvddgrrhr
      241 ahheperlsr rsedeqrwgk gpgqdrgkkg sqdsgapgea merlgraqrc ddspaprker
      301 lankdrpalq lydpgarfra recggnrric kaegsgtgpe kreeae
//
LOCUS       XP_011533148             315 aa            linear   PRI 05-AUG-2025
DEFINITION  regulator of nonsense transcripts 3A isoform X3 [Homo sapiens].
ACCESSION   XP_011533148
VERSION     XP_011533148.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534846.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..315
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..315
                     /product="regulator of nonsense transcripts 3A isoform X3"
                     /calculated_mol_wt=36165
     Region          68..225
                     /region_name="Smg4_UPF3"
                     /note="Smg-4/UPF3 family; pfam03467"
                     /db_xref="CDD:460932"
     CDS             1..315
                     /gene="UPF3A"
                     /gene_synonym="HUPF3A; RENT3A; UPF3"
                     /coded_by="XM_011534846.2:40..987"
                     /db_xref="GeneID:65110"
                     /db_xref="HGNC:HGNC:20332"
                     /db_xref="MIM:605530"
ORIGIN      
        1 mrsekegagg lraavaargp sgreklsale vqfhrdsqqq eaetpptsss gcgggagkpr
       61 eekrtalskv virrlppglt keqleeqlrp lpahdyfeff aadlslyphl ysrayinfrn
      121 pddillfrdr fdgyifldsk gleypavvef apfqkiakkk lrkkdaktgs ieddpeykkf
      181 letycveeek tsanpetllg emeaktreli arrttplley iknrklekqr ireekreerr
      241 rrelekkrlr eeekrrrree erckkketdk qkkiaekevr iklvssgsgv lpssspaala
      301 csparlqrlw pagfs
//
LOCUS       XP_047286502             287 aa            linear   PRI 05-AUG-2025
DEFINITION  regulator of nonsense transcripts 3A isoform X4 [Homo sapiens].
ACCESSION   XP_047286502
VERSION     XP_047286502.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430546.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..287
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..287
                     /product="regulator of nonsense transcripts 3A isoform X4"
                     /calculated_mol_wt=33525
     Region          66..152
                     /region_name="RRM_like_Smg4_UPF3A"
                     /note="RNA recognition motif (RRM)-like Smg4_UPF3 domain
                     in up-frameshift suppressor 3 homolog A (Upf3A); cd12727"
                     /db_xref="CDD:410126"
     CDS             1..287
                     /gene="UPF3A"
                     /gene_synonym="HUPF3A; RENT3A; UPF3"
                     /coded_by="XM_047430546.1:40..903"
                     /db_xref="GeneID:65110"
                     /db_xref="HGNC:HGNC:20332"
                     /db_xref="MIM:605530"
ORIGIN      
        1 mrsekegagg lraavaargp sgreklsale vqfhrdsqqq eaetpptsss gcgggagkpr
       61 eekrtalskv virrlppglt keqleeqlrp lpahdyfeff aadlslyphl ysrayinfrn
      121 pddillfrdr fdgyifldsk gleypavvef apfqkiakkk lrkkdaktgs ieddpeykkf
      181 letycveeek tsanpetllg emeaktreli arrttplley iknrklekqr ireekreerr
      241 rrelekkrlr eeekrrrree erckkketdk qkkiaekevr ikvtqrq
//
LOCUS       XP_047286503             284 aa            linear   PRI 05-AUG-2025
DEFINITION  regulator of nonsense transcripts 3A isoform X5 [Homo sapiens].
ACCESSION   XP_047286503
VERSION     XP_047286503.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430547.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..284
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..284
                     /product="regulator of nonsense transcripts 3A isoform X5"
                     /calculated_mol_wt=31641
     Region          66..152
                     /region_name="RRM_like_Smg4_UPF3A"
                     /note="RNA recognition motif (RRM)-like Smg4_UPF3 domain
                     in up-frameshift suppressor 3 homolog A (Upf3A); cd12727"
                     /db_xref="CDD:410126"
     CDS             1..284
                     /gene="UPF3A"
                     /gene_synonym="HUPF3A; RENT3A; UPF3"
                     /coded_by="XM_047430547.1:40..894"
                     /db_xref="GeneID:65110"
                     /db_xref="HGNC:HGNC:20332"
                     /db_xref="MIM:605530"
ORIGIN      
        1 mrsekegagg lraavaargp sgreklsale vqfhrdsqqq eaetpptsss gcgggagkpr
       61 eekrtalskv virrlppglt keqleeqlrp lpahdyfeff aadlslyphl ysrayinfrn
      121 pddillfrdr fdgyifldsk gleypavvef apfqkiakkk lrkkdaktgs ieddpeykkf
      181 letycveeek tsanpetllg emeaktreli gcalpthqdg ctlggqggri trsglrdqpg
      241 rhgetpsllk iqkisrawwc vpivpateea eagesleprr rrlq
//
LOCUS       XP_047286504             275 aa            linear   PRI 05-AUG-2025
DEFINITION  regulator of nonsense transcripts 3A isoform X6 [Homo sapiens].
ACCESSION   XP_047286504
VERSION     XP_047286504.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430548.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..275
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..275
                     /product="regulator of nonsense transcripts 3A isoform X6"
                     /calculated_mol_wt=31953
     Region          89..>257
                     /region_name="PRK12678"
                     /note="transcription termination factor Rho; Provisional"
                     /db_xref="CDD:237171"
     CDS             1..275
                     /gene="UPF3A"
                     /gene_synonym="HUPF3A; RENT3A; UPF3"
                     /coded_by="XM_047430548.1:449..1276"
                     /db_xref="GeneID:65110"
                     /db_xref="HGNC:HGNC:20332"
                     /db_xref="MIM:605530"
ORIGIN      
        1 meaktrelia rrttplleyi knrklekqri reekreerrr relekkrlre eekrrrreee
       61 rckkketdkq kkiaekevri kllkkpekge epttekpker geeidtgggk qescapgavv
      121 karpmegsle epqetshsgs dkehrdvers qeqeseaqry hvddgrrhra hheperlsrr
      181 sedeqrwgkg pgqdrgkkgs qdsgapgeam erlgraqrcd dspaprkerl ankdrpalql
      241 ydpgarfrar ecggnrrick aegsgtgpek reeae
//
LOCUS       XP_024305170             261 aa            linear   PRI 05-AUG-2025
DEFINITION  regulator of nonsense transcripts 3A isoform X7 [Homo sapiens].
ACCESSION   XP_024305170
VERSION     XP_024305170.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449402.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..261
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..261
                     /product="regulator of nonsense transcripts 3A isoform X7"
                     /calculated_mol_wt=29838
     Region          66..152
                     /region_name="RRM_like_Smg4_UPF3A"
                     /note="RNA recognition motif (RRM)-like Smg4_UPF3 domain
                     in up-frameshift suppressor 3 homolog A (Upf3A); cd12727"
                     /db_xref="CDD:410126"
     CDS             1..261
                     /gene="UPF3A"
                     /gene_synonym="HUPF3A; RENT3A; UPF3"
                     /coded_by="XM_024449402.2:40..825"
                     /db_xref="GeneID:65110"
                     /db_xref="HGNC:HGNC:20332"
                     /db_xref="MIM:605530"
ORIGIN      
        1 mrsekegagg lraavaargp sgreklsale vqfhrdsqqq eaetpptsss gcgggagkpr
       61 eekrtalskv virrlppglt keqleeqlrp lpahdyfeff aadlslyphl ysrayinfrn
      121 pddillfrdr fdgyifldsk gleypavvef apfqkiakkk lrkkdaktgs ieddpeykkf
      181 letycveeek tsanpetllg emeaktreli gslytrssms lensrrearr teeervrket
      241 fagrgkkkkk rrrkmqkkrd r
//
LOCUS       XP_047286505             254 aa            linear   PRI 05-AUG-2025
DEFINITION  regulator of nonsense transcripts 3A isoform X8 [Homo sapiens].
ACCESSION   XP_047286505
VERSION     XP_047286505.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430549.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..254
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..254
                     /product="regulator of nonsense transcripts 3A isoform X8"
                     /calculated_mol_wt=29837
     Region          66..149
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:473069"
     CDS             1..254
                     /gene="UPF3A"
                     /gene_synonym="HUPF3A; RENT3A; UPF3"
                     /coded_by="XM_047430549.1:40..804"
                     /db_xref="GeneID:65110"
                     /db_xref="HGNC:HGNC:20332"
                     /db_xref="MIM:605530"
ORIGIN      
        1 mrsekegagg lraavaargp sgreklsale vqfhrdsqqq eaetpptsss gcgggagkpr
       61 eekrtalskv virrlppglt keqleeqlrp lpahdyfeff aadlslyphl ysrayinfrn
      121 pddillfrdr fdgyifldsk dpeykkflet ycveeektsa npetllgeme aktreliarr
      181 ttplleyikn rklekqrire ekreerrrre lekkrlreee krrrreeerc kkketdkqkk
      241 iaekevrikv tqrq
//
LOCUS       XP_024305171             219 aa            linear   PRI 05-AUG-2025
DEFINITION  regulator of nonsense transcripts 3A isoform X9 [Homo sapiens].
ACCESSION   XP_024305171
VERSION     XP_024305171.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449403.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..219
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..219
                     /product="regulator of nonsense transcripts 3A isoform X9"
                     /calculated_mol_wt=24570
     Region          66..152
                     /region_name="RRM_like_Smg4_UPF3A"
                     /note="RNA recognition motif (RRM)-like Smg4_UPF3 domain
                     in up-frameshift suppressor 3 homolog A (Upf3A); cd12727"
                     /db_xref="CDD:410126"
     CDS             1..219
                     /gene="UPF3A"
                     /gene_synonym="HUPF3A; RENT3A; UPF3"
                     /coded_by="XM_024449403.2:40..699"
                     /db_xref="GeneID:65110"
                     /db_xref="HGNC:HGNC:20332"
                     /db_xref="MIM:605530"
ORIGIN      
        1 mrsekegagg lraavaargp sgreklsale vqfhrdsqqq eaetpptsss gcgggagkpr
       61 eekrtalskv virrlppglt keqleeqlrp lpahdyfeff aadlslyphl ysrayinfrn
      121 pddillfrdr fdgyifldsk gleypavvef apfqkiakkk lrkkdaktgs ieddpeykkf
      181 letycveeek tsanpetllg emeaktreli vythalpcl
//
LOCUS       XP_024305169             275 aa            linear   PRI 05-AUG-2025
DEFINITION  regulator of nonsense transcripts 3A isoform X6 [Homo sapiens].
ACCESSION   XP_024305169
VERSION     XP_024305169.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449401.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..275
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..275
                     /product="regulator of nonsense transcripts 3A isoform X6"
                     /calculated_mol_wt=31953
     Region          89..>257
                     /region_name="PRK12678"
                     /note="transcription termination factor Rho; Provisional"
                     /db_xref="CDD:237171"
     CDS             1..275
                     /gene="UPF3A"
                     /gene_synonym="HUPF3A; RENT3A; UPF3"
                     /coded_by="XM_024449401.2:109..936"
                     /db_xref="GeneID:65110"
                     /db_xref="HGNC:HGNC:20332"
                     /db_xref="MIM:605530"
ORIGIN      
        1 meaktrelia rrttplleyi knrklekqri reekreerrr relekkrlre eekrrrreee
       61 rckkketdkq kkiaekevri kllkkpekge epttekpker geeidtgggk qescapgavv
      121 karpmegsle epqetshsgs dkehrdvers qeqeseaqry hvddgrrhra hheperlsrr
      181 sedeqrwgkg pgqdrgkkgs qdsgapgeam erlgraqrcd dspaprkerl ankdrpalql
      241 ydpgarfrar ecggnrrick aegsgtgpek reeae
//
LOCUS       XP_047286506             629 aa            linear   PRI 05-AUG-2025
DEFINITION  high affinity cationic amino acid transporter 1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_047286506
VERSION     XP_047286506.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430550.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..629
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..629
                     /product="high affinity cationic amino acid transporter 1
                     isoform X1"
                     /calculated_mol_wt=67508
     Region          4..610
                     /region_name="2A0303"
                     /note="cationic amino acid transport permease; TIGR00906"
                     /db_xref="CDD:273330"
     CDS             1..629
                     /gene="SLC7A1"
                     /gene_synonym="ATRC1; CAT-1; ERR; HCAT1; REC1L"
                     /coded_by="XM_047430550.1:660..2549"
                     /db_xref="GeneID:6541"
                     /db_xref="HGNC:HGNC:11057"
                     /db_xref="MIM:104615"
ORIGIN      
        1 mgckvllnig qqmlrrkvvd csreetrlsr clntfdlval gvgstlgagv yvlagavare
       61 nagpaivisf liaalasvla glcygefgar vpktgsayly syvtvgelwa fitgwnlils
      121 yiigtssvar awsatfdeli grpigefsrt hmtlnapgvl aenpdifavi iililtgllt
      181 lgvkesamvn kiftcinvlv lgfimvsgfv kgsvknwqlt eedfgntsgr lclnndtkeg
      241 kpgvggfmpf gfsgvlsgaa tcfyafvgfd ciattgeevk npqkaipvgi vasllicfia
      301 yfgvsaaltl mmpyfcldnn splpdafkhv gwegakyava vgslcalsas llgsmfpmpr
      361 viyamaedgl lfkflanvnd rtktpiiatl asgavaavma flfdlkdlvd lmsigtllay
      421 slvaacvlvl ryqpeqpnlv yqmastsdel dpadqnelas tndsqlgflp eaemfslkti
      481 lspknmepsk isglivnist sliavliitf civtvlgrea ltkgalwavf llagsallca
      541 vvtgviwrqp esktklsfkv pflpvlpils ifvnvylmmq ldqgtwvrfa vwmligfiiy
      601 fgyglwhsee asldadqart pdgnldqck
//
LOCUS       XP_047286507             629 aa            linear   PRI 05-AUG-2025
DEFINITION  high affinity cationic amino acid transporter 1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_047286507
VERSION     XP_047286507.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430551.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..629
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..629
                     /product="high affinity cationic amino acid transporter 1
                     isoform X1"
                     /calculated_mol_wt=67508
     Region          4..610
                     /region_name="2A0303"
                     /note="cationic amino acid transport permease; TIGR00906"
                     /db_xref="CDD:273330"
     CDS             1..629
                     /gene="SLC7A1"
                     /gene_synonym="ATRC1; CAT-1; ERR; HCAT1; REC1L"
                     /coded_by="XM_047430551.1:182..2071"
                     /db_xref="GeneID:6541"
                     /db_xref="HGNC:HGNC:11057"
                     /db_xref="MIM:104615"
ORIGIN      
        1 mgckvllnig qqmlrrkvvd csreetrlsr clntfdlval gvgstlgagv yvlagavare
       61 nagpaivisf liaalasvla glcygefgar vpktgsayly syvtvgelwa fitgwnlils
      121 yiigtssvar awsatfdeli grpigefsrt hmtlnapgvl aenpdifavi iililtgllt
      181 lgvkesamvn kiftcinvlv lgfimvsgfv kgsvknwqlt eedfgntsgr lclnndtkeg
      241 kpgvggfmpf gfsgvlsgaa tcfyafvgfd ciattgeevk npqkaipvgi vasllicfia
      301 yfgvsaaltl mmpyfcldnn splpdafkhv gwegakyava vgslcalsas llgsmfpmpr
      361 viyamaedgl lfkflanvnd rtktpiiatl asgavaavma flfdlkdlvd lmsigtllay
      421 slvaacvlvl ryqpeqpnlv yqmastsdel dpadqnelas tndsqlgflp eaemfslkti
      481 lspknmepsk isglivnist sliavliitf civtvlgrea ltkgalwavf llagsallca
      541 vvtgviwrqp esktklsfkv pflpvlpils ifvnvylmmq ldqgtwvrfa vwmligfiiy
      601 fgyglwhsee asldadqart pdgnldqck
//
LOCUS       XP_005266564             629 aa            linear   PRI 05-AUG-2025
DEFINITION  high affinity cationic amino acid transporter 1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_005266564
VERSION     XP_005266564.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266507.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..629
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..629
                     /product="high affinity cationic amino acid transporter 1
                     isoform X1"
                     /calculated_mol_wt=67508
     Region          4..610
                     /region_name="2A0303"
                     /note="cationic amino acid transport permease; TIGR00906"
                     /db_xref="CDD:273330"
     CDS             1..629
                     /gene="SLC7A1"
                     /gene_synonym="ATRC1; CAT-1; ERR; HCAT1; REC1L"
                     /coded_by="XM_005266507.4:183..2072"
                     /db_xref="GeneID:6541"
                     /db_xref="HGNC:HGNC:11057"
                     /db_xref="MIM:104615"
ORIGIN      
        1 mgckvllnig qqmlrrkvvd csreetrlsr clntfdlval gvgstlgagv yvlagavare
       61 nagpaivisf liaalasvla glcygefgar vpktgsayly syvtvgelwa fitgwnlils
      121 yiigtssvar awsatfdeli grpigefsrt hmtlnapgvl aenpdifavi iililtgllt
      181 lgvkesamvn kiftcinvlv lgfimvsgfv kgsvknwqlt eedfgntsgr lclnndtkeg
      241 kpgvggfmpf gfsgvlsgaa tcfyafvgfd ciattgeevk npqkaipvgi vasllicfia
      301 yfgvsaaltl mmpyfcldnn splpdafkhv gwegakyava vgslcalsas llgsmfpmpr
      361 viyamaedgl lfkflanvnd rtktpiiatl asgavaavma flfdlkdlvd lmsigtllay
      421 slvaacvlvl ryqpeqpnlv yqmastsdel dpadqnelas tndsqlgflp eaemfslkti
      481 lspknmepsk isglivnist sliavliitf civtvlgrea ltkgalwavf llagsallca
      541 vvtgviwrqp esktklsfkv pflpvlpils ifvnvylmmq ldqgtwvrfa vwmligfiiy
      601 fgyglwhsee asldadqart pdgnldqck
//
LOCUS       XP_047286508             629 aa            linear   PRI 05-AUG-2025
DEFINITION  high affinity cationic amino acid transporter 1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_047286508
VERSION     XP_047286508.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430552.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..629
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..629
                     /product="high affinity cationic amino acid transporter 1
                     isoform X1"
                     /calculated_mol_wt=67508
     Region          4..610
                     /region_name="2A0303"
                     /note="cationic amino acid transport permease; TIGR00906"
                     /db_xref="CDD:273330"
     CDS             1..629
                     /gene="SLC7A1"
                     /gene_synonym="ATRC1; CAT-1; ERR; HCAT1; REC1L"
                     /coded_by="XM_047430552.1:1085..2974"
                     /db_xref="GeneID:6541"
                     /db_xref="HGNC:HGNC:11057"
                     /db_xref="MIM:104615"
ORIGIN      
        1 mgckvllnig qqmlrrkvvd csreetrlsr clntfdlval gvgstlgagv yvlagavare
       61 nagpaivisf liaalasvla glcygefgar vpktgsayly syvtvgelwa fitgwnlils
      121 yiigtssvar awsatfdeli grpigefsrt hmtlnapgvl aenpdifavi iililtgllt
      181 lgvkesamvn kiftcinvlv lgfimvsgfv kgsvknwqlt eedfgntsgr lclnndtkeg
      241 kpgvggfmpf gfsgvlsgaa tcfyafvgfd ciattgeevk npqkaipvgi vasllicfia
      301 yfgvsaaltl mmpyfcldnn splpdafkhv gwegakyava vgslcalsas llgsmfpmpr
      361 viyamaedgl lfkflanvnd rtktpiiatl asgavaavma flfdlkdlvd lmsigtllay
      421 slvaacvlvl ryqpeqpnlv yqmastsdel dpadqnelas tndsqlgflp eaemfslkti
      481 lspknmepsk isglivnist sliavliitf civtvlgrea ltkgalwavf llagsallca
      541 vvtgviwrqp esktklsfkv pflpvlpils ifvnvylmmq ldqgtwvrfa vwmligfiiy
      601 fgyglwhsee asldadqart pdgnldqck
//
LOCUS       XP_047286509             383 aa            linear   PRI 05-AUG-2025
DEFINITION  Krueppel-like factor 5 isoform X1 [Homo sapiens].
ACCESSION   XP_047286509
VERSION     XP_047286509.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430553.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..383
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..383
                     /product="Krueppel-like factor 5 isoform X1"
                     /calculated_mol_wt=42948
     Region          14..296
                     /region_name="KLF5_N"
                     /note="N-terminal domain of Kruppel-like factor 5;
                     cd21579"
                     /db_xref="CDD:410335"
     Region          285..>359
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          304..323
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(308,310,312,314..315,318..319,322,338,340,344..345,
                     348..349,352,366,368,370,372..373,376..377,380)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          331..353
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          345..370
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          359..381
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          361..381
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..383
                     /gene="KLF5"
                     /gene_synonym="BTEB2; CKLF; IKLF"
                     /coded_by="XM_047430553.1:120..1271"
                     /db_xref="GeneID:688"
                     /db_xref="HGNC:HGNC:6349"
                     /db_xref="MIM:602903"
ORIGIN      
        1 megnlprrvg lgetrcemek yltpqlppvp iipehkkyrr dsasvvdqff tdteglpysi
       61 nmnvflpdit hlrtglyksq rpcvthikte pvaifshqse ttapppaptq alpeftsifs
      121 shqtaapevn nifikqelpt pdlhlsvptq qghlyqllnt pdldmpsstn qtaamdtlnv
      181 smsaamagln thtsavpqta vkqfqgmppc tytmpsqflp qqatyfppsp pssepgspdr
      241 qaemlqnltp ppsyaatias klaihnpnlp ttlpvnsqni qpvrynrrsn pdlekrrihy
      301 cdypgctkvy tksshlkahl rthtgekpyk ctwegcdwrf arsdeltrhy rkhtgakpfq
      361 cgvcnrsfsr sdhlalhmkr hqn
//
LOCUS       XP_047286510             476 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor Dp-1 isoform X1 [Homo sapiens].
ACCESSION   XP_047286510
VERSION     XP_047286510.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430554.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..476
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..476
                     /product="transcription factor Dp-1 isoform X1"
                     /calculated_mol_wt=52433
     Region          112..193
                     /region_name="E2F_TDP"
                     /note="E2F/DP family winged-helix DNA-binding domain;
                     pfam02319"
                     /db_xref="CDD:460530"
     Site            order(198,202,205..206,208..209,212..213,215..216,
                     219..220,223,226..227,230,233..234,236..237,239..241,244,
                     255..266,268,279..287,289,291,293,299..300,302)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:271217"
     Region          198..244
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:271217"
     Region          200..336
                     /region_name="DP"
                     /note="Transcription factor DP; pfam08781"
                     /db_xref="CDD:462601"
     Site            order(222,225..226,229,262,271,273,288..295,302)
                     /site_type="other"
                     /note="RbC binding site [polypeptide binding]"
                     /db_xref="CDD:271217"
     CDS             1..476
                     /gene="TFDP1"
                     /gene_synonym="DILC; Dp-1; DP1; DRTF1"
                     /coded_by="XM_047430554.1:201..1631"
                     /db_xref="GeneID:7027"
                     /db_xref="HGNC:HGNC:11749"
                     /db_xref="MIM:189902"
ORIGIN      
        1 makdagliea ngelkvfidq nlspgkgvvs lvavhpstvn plgkqllpkt fgqsnvniaq
       61 qvvigtpqrp aasntlvvgs phtpsthfas qnqpsdsspw sagkrnrkge kngkglrhfs
      121 mkvcekvqrk gttsynevad elvaefsaad nhilpnesay dqknirrrvy dalnvlmamn
      181 iiskekkeik wiglptnsaq ecqnleverq rrlerikqkq sqlqelilqq iafknlvqrn
      241 rhaeqqasrp pppnsvihlp fiivntskkt vidcsisndk feylfnfdnt feihddievl
      301 krmgmacgle sgscsaedlk marslvpkal epyvtektgl cdctagcpap wrsventgqa
      361 kdirkllqps vlwncasfcw lpvrlvlflf hdhsliffpf semaqgtvgg vfittagsts
      421 ngtrfsasdl tngadgmlat ssngsqysgs rvetpvsyvg eddeedddfn endedd
//
LOCUS       XP_047286513             476 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor Dp-1 isoform X1 [Homo sapiens].
ACCESSION   XP_047286513
VERSION     XP_047286513.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430557.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..476
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..476
                     /product="transcription factor Dp-1 isoform X1"
                     /calculated_mol_wt=52433
     Region          112..193
                     /region_name="E2F_TDP"
                     /note="E2F/DP family winged-helix DNA-binding domain;
                     pfam02319"
                     /db_xref="CDD:460530"
     Site            order(198,202,205..206,208..209,212..213,215..216,
                     219..220,223,226..227,230,233..234,236..237,239..241,244,
                     255..266,268,279..287,289,291,293,299..300,302)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:271217"
     Region          198..244
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:271217"
     Region          200..336
                     /region_name="DP"
                     /note="Transcription factor DP; pfam08781"
                     /db_xref="CDD:462601"
     Site            order(222,225..226,229,262,271,273,288..295,302)
                     /site_type="other"
                     /note="RbC binding site [polypeptide binding]"
                     /db_xref="CDD:271217"
     CDS             1..476
                     /gene="TFDP1"
                     /gene_synonym="DILC; Dp-1; DP1; DRTF1"
                     /coded_by="XM_047430557.1:257..1687"
                     /db_xref="GeneID:7027"
                     /db_xref="HGNC:HGNC:11749"
                     /db_xref="MIM:189902"
ORIGIN      
        1 makdagliea ngelkvfidq nlspgkgvvs lvavhpstvn plgkqllpkt fgqsnvniaq
       61 qvvigtpqrp aasntlvvgs phtpsthfas qnqpsdsspw sagkrnrkge kngkglrhfs
      121 mkvcekvqrk gttsynevad elvaefsaad nhilpnesay dqknirrrvy dalnvlmamn
      181 iiskekkeik wiglptnsaq ecqnleverq rrlerikqkq sqlqelilqq iafknlvqrn
      241 rhaeqqasrp pppnsvihlp fiivntskkt vidcsisndk feylfnfdnt feihddievl
      301 krmgmacgle sgscsaedlk marslvpkal epyvtektgl cdctagcpap wrsventgqa
      361 kdirkllqps vlwncasfcw lpvrlvlflf hdhsliffpf semaqgtvgg vfittagsts
      421 ngtrfsasdl tngadgmlat ssngsqysgs rvetpvsyvg eddeedddfn endedd
//
LOCUS       XP_016876206             476 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor Dp-1 isoform X1 [Homo sapiens].
ACCESSION   XP_016876206
VERSION     XP_016876206.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020717.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..476
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..476
                     /product="transcription factor Dp-1 isoform X1"
                     /calculated_mol_wt=52433
     Region          112..193
                     /region_name="E2F_TDP"
                     /note="E2F/DP family winged-helix DNA-binding domain;
                     pfam02319"
                     /db_xref="CDD:460530"
     Site            order(198,202,205..206,208..209,212..213,215..216,
                     219..220,223,226..227,230,233..234,236..237,239..241,244,
                     255..266,268,279..287,289,291,293,299..300,302)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:271217"
     Region          198..244
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:271217"
     Region          200..336
                     /region_name="DP"
                     /note="Transcription factor DP; pfam08781"
                     /db_xref="CDD:462601"
     Site            order(222,225..226,229,262,271,273,288..295,302)
                     /site_type="other"
                     /note="RbC binding site [polypeptide binding]"
                     /db_xref="CDD:271217"
     CDS             1..476
                     /gene="TFDP1"
                     /gene_synonym="DILC; Dp-1; DP1; DRTF1"
                     /coded_by="XM_017020717.2:108..1538"
                     /db_xref="GeneID:7027"
                     /db_xref="HGNC:HGNC:11749"
                     /db_xref="MIM:189902"
ORIGIN      
        1 makdagliea ngelkvfidq nlspgkgvvs lvavhpstvn plgkqllpkt fgqsnvniaq
       61 qvvigtpqrp aasntlvvgs phtpsthfas qnqpsdsspw sagkrnrkge kngkglrhfs
      121 mkvcekvqrk gttsynevad elvaefsaad nhilpnesay dqknirrrvy dalnvlmamn
      181 iiskekkeik wiglptnsaq ecqnleverq rrlerikqkq sqlqelilqq iafknlvqrn
      241 rhaeqqasrp pppnsvihlp fiivntskkt vidcsisndk feylfnfdnt feihddievl
      301 krmgmacgle sgscsaedlk marslvpkal epyvtektgl cdctagcpap wrsventgqa
      361 kdirkllqps vlwncasfcw lpvrlvlflf hdhsliffpf semaqgtvgg vfittagsts
      421 ngtrfsasdl tngadgmlat ssngsqysgs rvetpvsyvg eddeedddfn endedd
//
LOCUS       XP_047286514             476 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor Dp-1 isoform X1 [Homo sapiens].
ACCESSION   XP_047286514
VERSION     XP_047286514.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430558.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..476
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..476
                     /product="transcription factor Dp-1 isoform X1"
                     /calculated_mol_wt=52433
     Region          112..193
                     /region_name="E2F_TDP"
                     /note="E2F/DP family winged-helix DNA-binding domain;
                     pfam02319"
                     /db_xref="CDD:460530"
     Site            order(198,202,205..206,208..209,212..213,215..216,
                     219..220,223,226..227,230,233..234,236..237,239..241,244,
                     255..266,268,279..287,289,291,293,299..300,302)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:271217"
     Region          198..244
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:271217"
     Region          200..336
                     /region_name="DP"
                     /note="Transcription factor DP; pfam08781"
                     /db_xref="CDD:462601"
     Site            order(222,225..226,229,262,271,273,288..295,302)
                     /site_type="other"
                     /note="RbC binding site [polypeptide binding]"
                     /db_xref="CDD:271217"
     CDS             1..476
                     /gene="TFDP1"
                     /gene_synonym="DILC; Dp-1; DP1; DRTF1"
                     /coded_by="XM_047430558.1:193..1623"
                     /db_xref="GeneID:7027"
                     /db_xref="HGNC:HGNC:11749"
                     /db_xref="MIM:189902"
ORIGIN      
        1 makdagliea ngelkvfidq nlspgkgvvs lvavhpstvn plgkqllpkt fgqsnvniaq
       61 qvvigtpqrp aasntlvvgs phtpsthfas qnqpsdsspw sagkrnrkge kngkglrhfs
      121 mkvcekvqrk gttsynevad elvaefsaad nhilpnesay dqknirrrvy dalnvlmamn
      181 iiskekkeik wiglptnsaq ecqnleverq rrlerikqkq sqlqelilqq iafknlvqrn
      241 rhaeqqasrp pppnsvihlp fiivntskkt vidcsisndk feylfnfdnt feihddievl
      301 krmgmacgle sgscsaedlk marslvpkal epyvtektgl cdctagcpap wrsventgqa
      361 kdirkllqps vlwncasfcw lpvrlvlflf hdhsliffpf semaqgtvgg vfittagsts
      421 ngtrfsasdl tngadgmlat ssngsqysgs rvetpvsyvg eddeedddfn endedd
//
LOCUS       XP_047286515             476 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor Dp-1 isoform X1 [Homo sapiens].
ACCESSION   XP_047286515
VERSION     XP_047286515.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430559.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..476
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..476
                     /product="transcription factor Dp-1 isoform X1"
                     /calculated_mol_wt=52433
     Region          112..193
                     /region_name="E2F_TDP"
                     /note="E2F/DP family winged-helix DNA-binding domain;
                     pfam02319"
                     /db_xref="CDD:460530"
     Site            order(198,202,205..206,208..209,212..213,215..216,
                     219..220,223,226..227,230,233..234,236..237,239..241,244,
                     255..266,268,279..287,289,291,293,299..300,302)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:271217"
     Region          198..244
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:271217"
     Region          200..336
                     /region_name="DP"
                     /note="Transcription factor DP; pfam08781"
                     /db_xref="CDD:462601"
     Site            order(222,225..226,229,262,271,273,288..295,302)
                     /site_type="other"
                     /note="RbC binding site [polypeptide binding]"
                     /db_xref="CDD:271217"
     CDS             1..476
                     /gene="TFDP1"
                     /gene_synonym="DILC; Dp-1; DP1; DRTF1"
                     /coded_by="XM_047430559.1:317..1747"
                     /db_xref="GeneID:7027"
                     /db_xref="HGNC:HGNC:11749"
                     /db_xref="MIM:189902"
ORIGIN      
        1 makdagliea ngelkvfidq nlspgkgvvs lvavhpstvn plgkqllpkt fgqsnvniaq
       61 qvvigtpqrp aasntlvvgs phtpsthfas qnqpsdsspw sagkrnrkge kngkglrhfs
      121 mkvcekvqrk gttsynevad elvaefsaad nhilpnesay dqknirrrvy dalnvlmamn
      181 iiskekkeik wiglptnsaq ecqnleverq rrlerikqkq sqlqelilqq iafknlvqrn
      241 rhaeqqasrp pppnsvihlp fiivntskkt vidcsisndk feylfnfdnt feihddievl
      301 krmgmacgle sgscsaedlk marslvpkal epyvtektgl cdctagcpap wrsventgqa
      361 kdirkllqps vlwncasfcw lpvrlvlflf hdhsliffpf semaqgtvgg vfittagsts
      421 ngtrfsasdl tngadgmlat ssngsqysgs rvetpvsyvg eddeedddfn endedd
//
LOCUS       XP_047286516             476 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor Dp-1 isoform X1 [Homo sapiens].
ACCESSION   XP_047286516
VERSION     XP_047286516.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430560.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..476
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..476
                     /product="transcription factor Dp-1 isoform X1"
                     /calculated_mol_wt=52433
     Region          112..193
                     /region_name="E2F_TDP"
                     /note="E2F/DP family winged-helix DNA-binding domain;
                     pfam02319"
                     /db_xref="CDD:460530"
     Site            order(198,202,205..206,208..209,212..213,215..216,
                     219..220,223,226..227,230,233..234,236..237,239..241,244,
                     255..266,268,279..287,289,291,293,299..300,302)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:271217"
     Region          198..244
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:271217"
     Region          200..336
                     /region_name="DP"
                     /note="Transcription factor DP; pfam08781"
                     /db_xref="CDD:462601"
     Site            order(222,225..226,229,262,271,273,288..295,302)
                     /site_type="other"
                     /note="RbC binding site [polypeptide binding]"
                     /db_xref="CDD:271217"
     CDS             1..476
                     /gene="TFDP1"
                     /gene_synonym="DILC; Dp-1; DP1; DRTF1"
                     /coded_by="XM_047430560.1:90..1520"
                     /db_xref="GeneID:7027"
                     /db_xref="HGNC:HGNC:11749"
                     /db_xref="MIM:189902"
ORIGIN      
        1 makdagliea ngelkvfidq nlspgkgvvs lvavhpstvn plgkqllpkt fgqsnvniaq
       61 qvvigtpqrp aasntlvvgs phtpsthfas qnqpsdsspw sagkrnrkge kngkglrhfs
      121 mkvcekvqrk gttsynevad elvaefsaad nhilpnesay dqknirrrvy dalnvlmamn
      181 iiskekkeik wiglptnsaq ecqnleverq rrlerikqkq sqlqelilqq iafknlvqrn
      241 rhaeqqasrp pppnsvihlp fiivntskkt vidcsisndk feylfnfdnt feihddievl
      301 krmgmacgle sgscsaedlk marslvpkal epyvtektgl cdctagcpap wrsventgqa
      361 kdirkllqps vlwncasfcw lpvrlvlflf hdhsliffpf semaqgtvgg vfittagsts
      421 ngtrfsasdl tngadgmlat ssngsqysgs rvetpvsyvg eddeedddfn endedd
//
LOCUS       XP_047286517             472 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor Dp-1 isoform X2 [Homo sapiens].
ACCESSION   XP_047286517
VERSION     XP_047286517.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430561.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..472
                     /product="transcription factor Dp-1 isoform X2"
                     /calculated_mol_wt=51972
     Region          112..193
                     /region_name="E2F_TDP"
                     /note="E2F/DP family winged-helix DNA-binding domain;
                     pfam02319"
                     /db_xref="CDD:460530"
     Site            order(198,202,205..206,208..209,212..213,215..216,
                     219..220,223,226..227,230,233..234,236..237,239..241,244,
                     255..266,268,279..287,289,291,293,299..300,302)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:271217"
     Region          198..244
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:271217"
     Region          200..336
                     /region_name="DP"
                     /note="Transcription factor DP; pfam08781"
                     /db_xref="CDD:462601"
     Site            order(222,225..226,229,262,271,273,288..295,302)
                     /site_type="other"
                     /note="RbC binding site [polypeptide binding]"
                     /db_xref="CDD:271217"
     CDS             1..472
                     /gene="TFDP1"
                     /gene_synonym="DILC; Dp-1; DP1; DRTF1"
                     /coded_by="XM_047430561.1:201..1619"
                     /db_xref="GeneID:7027"
                     /db_xref="HGNC:HGNC:11749"
                     /db_xref="MIM:189902"
ORIGIN      
        1 makdagliea ngelkvfidq nlspgkgvvs lvavhpstvn plgkqllpkt fgqsnvniaq
       61 qvvigtpqrp aasntlvvgs phtpsthfas qnqpsdsspw sagkrnrkge kngkglrhfs
      121 mkvcekvqrk gttsynevad elvaefsaad nhilpnesay dqknirrrvy dalnvlmamn
      181 iiskekkeik wiglptnsaq ecqnleverq rrlerikqkq sqlqelilqq iafknlvqrn
      241 rhaeqqasrp pppnsvihlp fiivntskkt vidcsisndk feylfnfdnt feihddievl
      301 krmgmacgle sgscsaedlk marslvpkal epyvtektgl cdctagcpap wrsventgqa
      361 kdirkllqps vlwncasfcw lpvrlvlflf hdhsliffpf semaqgtvgg vfittagsts
      421 ngtsdltnga dgmlatssng sqysgsrvet pvsyvgedde edddfnende dd
//
LOCUS       XP_047286518             410 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor Dp-1 isoform X3 [Homo sapiens].
ACCESSION   XP_047286518
VERSION     XP_047286518.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430562.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..410
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..410
                     /product="transcription factor Dp-1 isoform X3"
                     /calculated_mol_wt=44939
     Region          112..193
                     /region_name="E2F_TDP"
                     /note="E2F/DP family winged-helix DNA-binding domain;
                     pfam02319"
                     /db_xref="CDD:460530"
     Site            order(198,202,205..206,208..209,212..213,215..216,
                     219..220,223,226..227,230,233..234,236..237,239..241,244,
                     255..266,268,279..287,289,291,293,299..300,302)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:271217"
     Region          198..244
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:271217"
     Region          200..338
                     /region_name="DP"
                     /note="Transcription factor DP; pfam08781"
                     /db_xref="CDD:462601"
     Site            order(222,225..226,229,262,271,273,288..295,302)
                     /site_type="other"
                     /note="RbC binding site [polypeptide binding]"
                     /db_xref="CDD:271217"
     CDS             1..410
                     /gene="TFDP1"
                     /gene_synonym="DILC; Dp-1; DP1; DRTF1"
                     /coded_by="XM_047430562.1:740..1972"
                     /db_xref="GeneID:7027"
                     /db_xref="HGNC:HGNC:11749"
                     /db_xref="MIM:189902"
ORIGIN      
        1 makdagliea ngelkvfidq nlspgkgvvs lvavhpstvn plgkqllpkt fgqsnvniaq
       61 qvvigtpqrp aasntlvvgs phtpsthfas qnqpsdsspw sagkrnrkge kngkglrhfs
      121 mkvcekvqrk gttsynevad elvaefsaad nhilpnesay dqknirrrvy dalnvlmamn
      181 iiskekkeik wiglptnsaq ecqnleverq rrlerikqkq sqlqelilqq iafknlvqrn
      241 rhaeqqasrp pppnsvihlp fiivntskkt vidcsisndk feylfnfdnt feihddievl
      301 krmgmacgle sgscsaedlk marslvpkal epyvtemaqg tvggvfitta gstsngtrfs
      361 asdltngadg mlatssngsq ysgsrvetpv syvgeddeed ddfnendedd
//
LOCUS       XP_047286519             410 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor Dp-1 isoform X3 [Homo sapiens].
ACCESSION   XP_047286519
VERSION     XP_047286519.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430563.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..410
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..410
                     /product="transcription factor Dp-1 isoform X3"
                     /calculated_mol_wt=44939
     Region          112..193
                     /region_name="E2F_TDP"
                     /note="E2F/DP family winged-helix DNA-binding domain;
                     pfam02319"
                     /db_xref="CDD:460530"
     Site            order(198,202,205..206,208..209,212..213,215..216,
                     219..220,223,226..227,230,233..234,236..237,239..241,244,
                     255..266,268,279..287,289,291,293,299..300,302)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:271217"
     Region          198..244
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:271217"
     Region          200..338
                     /region_name="DP"
                     /note="Transcription factor DP; pfam08781"
                     /db_xref="CDD:462601"
     Site            order(222,225..226,229,262,271,273,288..295,302)
                     /site_type="other"
                     /note="RbC binding site [polypeptide binding]"
                     /db_xref="CDD:271217"
     CDS             1..410
                     /gene="TFDP1"
                     /gene_synonym="DILC; Dp-1; DP1; DRTF1"
                     /coded_by="XM_047430563.1:317..1549"
                     /db_xref="GeneID:7027"
                     /db_xref="HGNC:HGNC:11749"
                     /db_xref="MIM:189902"
ORIGIN      
        1 makdagliea ngelkvfidq nlspgkgvvs lvavhpstvn plgkqllpkt fgqsnvniaq
       61 qvvigtpqrp aasntlvvgs phtpsthfas qnqpsdsspw sagkrnrkge kngkglrhfs
      121 mkvcekvqrk gttsynevad elvaefsaad nhilpnesay dqknirrrvy dalnvlmamn
      181 iiskekkeik wiglptnsaq ecqnleverq rrlerikqkq sqlqelilqq iafknlvqrn
      241 rhaeqqasrp pppnsvihlp fiivntskkt vidcsisndk feylfnfdnt feihddievl
      301 krmgmacgle sgscsaedlk marslvpkal epyvtemaqg tvggvfitta gstsngtrfs
      361 asdltngadg mlatssngsq ysgsrvetpv syvgeddeed ddfnendedd
//
LOCUS       XP_005268384             410 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor Dp-1 isoform X3 [Homo sapiens].
ACCESSION   XP_005268384
VERSION     XP_005268384.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005268327.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..410
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..410
                     /product="transcription factor Dp-1 isoform X3"
                     /calculated_mol_wt=44939
     Region          112..193
                     /region_name="E2F_TDP"
                     /note="E2F/DP family winged-helix DNA-binding domain;
                     pfam02319"
                     /db_xref="CDD:460530"
     Site            order(198,202,205..206,208..209,212..213,215..216,
                     219..220,223,226..227,230,233..234,236..237,239..241,244,
                     255..266,268,279..287,289,291,293,299..300,302)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:271217"
     Region          198..244
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:271217"
     Region          200..338
                     /region_name="DP"
                     /note="Transcription factor DP; pfam08781"
                     /db_xref="CDD:462601"
     Site            order(222,225..226,229,262,271,273,288..295,302)
                     /site_type="other"
                     /note="RbC binding site [polypeptide binding]"
                     /db_xref="CDD:271217"
     CDS             1..410
                     /gene="TFDP1"
                     /gene_synonym="DILC; Dp-1; DP1; DRTF1"
                     /coded_by="XM_005268327.2:108..1340"
                     /db_xref="GeneID:7027"
                     /db_xref="HGNC:HGNC:11749"
                     /db_xref="MIM:189902"
ORIGIN      
        1 makdagliea ngelkvfidq nlspgkgvvs lvavhpstvn plgkqllpkt fgqsnvniaq
       61 qvvigtpqrp aasntlvvgs phtpsthfas qnqpsdsspw sagkrnrkge kngkglrhfs
      121 mkvcekvqrk gttsynevad elvaefsaad nhilpnesay dqknirrrvy dalnvlmamn
      181 iiskekkeik wiglptnsaq ecqnleverq rrlerikqkq sqlqelilqq iafknlvqrn
      241 rhaeqqasrp pppnsvihlp fiivntskkt vidcsisndk feylfnfdnt feihddievl
      301 krmgmacgle sgscsaedlk marslvpkal epyvtemaqg tvggvfitta gstsngtrfs
      361 asdltngadg mlatssngsq ysgsrvetpv syvgeddeed ddfnendedd
//
LOCUS       XP_047286520             410 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor Dp-1 isoform X3 [Homo sapiens].
ACCESSION   XP_047286520
VERSION     XP_047286520.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430564.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..410
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..410
                     /product="transcription factor Dp-1 isoform X3"
                     /calculated_mol_wt=44939
     Region          112..193
                     /region_name="E2F_TDP"
                     /note="E2F/DP family winged-helix DNA-binding domain;
                     pfam02319"
                     /db_xref="CDD:460530"
     Site            order(198,202,205..206,208..209,212..213,215..216,
                     219..220,223,226..227,230,233..234,236..237,239..241,244,
                     255..266,268,279..287,289,291,293,299..300,302)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:271217"
     Region          198..244
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:271217"
     Region          200..338
                     /region_name="DP"
                     /note="Transcription factor DP; pfam08781"
                     /db_xref="CDD:462601"
     Site            order(222,225..226,229,262,271,273,288..295,302)
                     /site_type="other"
                     /note="RbC binding site [polypeptide binding]"
                     /db_xref="CDD:271217"
     CDS             1..410
                     /gene="TFDP1"
                     /gene_synonym="DILC; Dp-1; DP1; DRTF1"
                     /coded_by="XM_047430564.1:225..1457"
                     /db_xref="GeneID:7027"
                     /db_xref="HGNC:HGNC:11749"
                     /db_xref="MIM:189902"
ORIGIN      
        1 makdagliea ngelkvfidq nlspgkgvvs lvavhpstvn plgkqllpkt fgqsnvniaq
       61 qvvigtpqrp aasntlvvgs phtpsthfas qnqpsdsspw sagkrnrkge kngkglrhfs
      121 mkvcekvqrk gttsynevad elvaefsaad nhilpnesay dqknirrrvy dalnvlmamn
      181 iiskekkeik wiglptnsaq ecqnleverq rrlerikqkq sqlqelilqq iafknlvqrn
      241 rhaeqqasrp pppnsvihlp fiivntskkt vidcsisndk feylfnfdnt feihddievl
      301 krmgmacgle sgscsaedlk marslvpkal epyvtemaqg tvggvfitta gstsngtrfs
      361 asdltngadg mlatssngsq ysgsrvetpv syvgeddeed ddfnendedd
//
LOCUS       XP_047286522             410 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor Dp-1 isoform X3 [Homo sapiens].
ACCESSION   XP_047286522
VERSION     XP_047286522.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430566.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..410
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..410
                     /product="transcription factor Dp-1 isoform X3"
                     /calculated_mol_wt=44939
     Region          112..193
                     /region_name="E2F_TDP"
                     /note="E2F/DP family winged-helix DNA-binding domain;
                     pfam02319"
                     /db_xref="CDD:460530"
     Site            order(198,202,205..206,208..209,212..213,215..216,
                     219..220,223,226..227,230,233..234,236..237,239..241,244,
                     255..266,268,279..287,289,291,293,299..300,302)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:271217"
     Region          198..244
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:271217"
     Region          200..338
                     /region_name="DP"
                     /note="Transcription factor DP; pfam08781"
                     /db_xref="CDD:462601"
     Site            order(222,225..226,229,262,271,273,288..295,302)
                     /site_type="other"
                     /note="RbC binding site [polypeptide binding]"
                     /db_xref="CDD:271217"
     CDS             1..410
                     /gene="TFDP1"
                     /gene_synonym="DILC; Dp-1; DP1; DRTF1"
                     /coded_by="XM_047430566.1:377..1609"
                     /db_xref="GeneID:7027"
                     /db_xref="HGNC:HGNC:11749"
                     /db_xref="MIM:189902"
ORIGIN      
        1 makdagliea ngelkvfidq nlspgkgvvs lvavhpstvn plgkqllpkt fgqsnvniaq
       61 qvvigtpqrp aasntlvvgs phtpsthfas qnqpsdsspw sagkrnrkge kngkglrhfs
      121 mkvcekvqrk gttsynevad elvaefsaad nhilpnesay dqknirrrvy dalnvlmamn
      181 iiskekkeik wiglptnsaq ecqnleverq rrlerikqkq sqlqelilqq iafknlvqrn
      241 rhaeqqasrp pppnsvihlp fiivntskkt vidcsisndk feylfnfdnt feihddievl
      301 krmgmacgle sgscsaedlk marslvpkal epyvtemaqg tvggvfitta gstsngtrfs
      361 asdltngadg mlatssngsq ysgsrvetpv syvgeddeed ddfnendedd
//
LOCUS       XP_005268385             406 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor Dp-1 isoform X4 [Homo sapiens].
ACCESSION   XP_005268385
VERSION     XP_005268385.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005268328.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..406
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..406
                     /product="transcription factor Dp-1 isoform X4"
                     /calculated_mol_wt=44478
     Region          112..193
                     /region_name="E2F_TDP"
                     /note="E2F/DP family winged-helix DNA-binding domain;
                     pfam02319"
                     /db_xref="CDD:460530"
     Site            order(198,202,205..206,208..209,212..213,215..216,
                     219..220,223,226..227,230,233..234,236..237,239..241,244,
                     255..266,268,279..287,289,291,293,299..300,302)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:271217"
     Region          198..244
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:271217"
     Region          200..338
                     /region_name="DP"
                     /note="Transcription factor DP; pfam08781"
                     /db_xref="CDD:462601"
     Site            order(222,225..226,229,262,271,273,288..295,302)
                     /site_type="other"
                     /note="RbC binding site [polypeptide binding]"
                     /db_xref="CDD:271217"
     CDS             1..406
                     /gene="TFDP1"
                     /gene_synonym="DILC; Dp-1; DP1; DRTF1"
                     /coded_by="XM_005268328.3:280..1500"
                     /db_xref="GeneID:7027"
                     /db_xref="HGNC:HGNC:11749"
                     /db_xref="MIM:189902"
ORIGIN      
        1 makdagliea ngelkvfidq nlspgkgvvs lvavhpstvn plgkqllpkt fgqsnvniaq
       61 qvvigtpqrp aasntlvvgs phtpsthfas qnqpsdsspw sagkrnrkge kngkglrhfs
      121 mkvcekvqrk gttsynevad elvaefsaad nhilpnesay dqknirrrvy dalnvlmamn
      181 iiskekkeik wiglptnsaq ecqnleverq rrlerikqkq sqlqelilqq iafknlvqrn
      241 rhaeqqasrp pppnsvihlp fiivntskkt vidcsisndk feylfnfdnt feihddievl
      301 krmgmacgle sgscsaedlk marslvpkal epyvtemaqg tvggvfitta gstsngtsdl
      361 tngadgmlat ssngsqysgs rvetpvsyvg eddeedddfn endedd
//
LOCUS       XP_047286523             406 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor Dp-1 isoform X4 [Homo sapiens].
ACCESSION   XP_047286523
VERSION     XP_047286523.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430567.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..406
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..406
                     /product="transcription factor Dp-1 isoform X4"
                     /calculated_mol_wt=44478
     Region          112..193
                     /region_name="E2F_TDP"
                     /note="E2F/DP family winged-helix DNA-binding domain;
                     pfam02319"
                     /db_xref="CDD:460530"
     Site            order(198,202,205..206,208..209,212..213,215..216,
                     219..220,223,226..227,230,233..234,236..237,239..241,244,
                     255..266,268,279..287,289,291,293,299..300,302)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:271217"
     Region          198..244
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:271217"
     Region          200..338
                     /region_name="DP"
                     /note="Transcription factor DP; pfam08781"
                     /db_xref="CDD:462601"
     Site            order(222,225..226,229,262,271,273,288..295,302)
                     /site_type="other"
                     /note="RbC binding site [polypeptide binding]"
                     /db_xref="CDD:271217"
     CDS             1..406
                     /gene="TFDP1"
                     /gene_synonym="DILC; Dp-1; DP1; DRTF1"
                     /coded_by="XM_047430567.1:317..1537"
                     /db_xref="GeneID:7027"
                     /db_xref="HGNC:HGNC:11749"
                     /db_xref="MIM:189902"
ORIGIN      
        1 makdagliea ngelkvfidq nlspgkgvvs lvavhpstvn plgkqllpkt fgqsnvniaq
       61 qvvigtpqrp aasntlvvgs phtpsthfas qnqpsdsspw sagkrnrkge kngkglrhfs
      121 mkvcekvqrk gttsynevad elvaefsaad nhilpnesay dqknirrrvy dalnvlmamn
      181 iiskekkeik wiglptnsaq ecqnleverq rrlerikqkq sqlqelilqq iafknlvqrn
      241 rhaeqqasrp pppnsvihlp fiivntskkt vidcsisndk feylfnfdnt feihddievl
      301 krmgmacgle sgscsaedlk marslvpkal epyvtemaqg tvggvfitta gstsngtsdl
      361 tngadgmlat ssngsqysgs rvetpvsyvg eddeedddfn endedd
//
LOCUS       XP_016876207             406 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor Dp-1 isoform X4 [Homo sapiens].
ACCESSION   XP_016876207
VERSION     XP_016876207.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020718.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..406
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..406
                     /product="transcription factor Dp-1 isoform X4"
                     /calculated_mol_wt=44478
     Region          112..193
                     /region_name="E2F_TDP"
                     /note="E2F/DP family winged-helix DNA-binding domain;
                     pfam02319"
                     /db_xref="CDD:460530"
     Site            order(198,202,205..206,208..209,212..213,215..216,
                     219..220,223,226..227,230,233..234,236..237,239..241,244,
                     255..266,268,279..287,289,291,293,299..300,302)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:271217"
     Region          198..244
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:271217"
     Region          200..338
                     /region_name="DP"
                     /note="Transcription factor DP; pfam08781"
                     /db_xref="CDD:462601"
     Site            order(222,225..226,229,262,271,273,288..295,302)
                     /site_type="other"
                     /note="RbC binding site [polypeptide binding]"
                     /db_xref="CDD:271217"
     CDS             1..406
                     /gene="TFDP1"
                     /gene_synonym="DILC; Dp-1; DP1; DRTF1"
                     /coded_by="XM_017020718.2:108..1328"
                     /db_xref="GeneID:7027"
                     /db_xref="HGNC:HGNC:11749"
                     /db_xref="MIM:189902"
ORIGIN      
        1 makdagliea ngelkvfidq nlspgkgvvs lvavhpstvn plgkqllpkt fgqsnvniaq
       61 qvvigtpqrp aasntlvvgs phtpsthfas qnqpsdsspw sagkrnrkge kngkglrhfs
      121 mkvcekvqrk gttsynevad elvaefsaad nhilpnesay dqknirrrvy dalnvlmamn
      181 iiskekkeik wiglptnsaq ecqnleverq rrlerikqkq sqlqelilqq iafknlvqrn
      241 rhaeqqasrp pppnsvihlp fiivntskkt vidcsisndk feylfnfdnt feihddievl
      301 krmgmacgle sgscsaedlk marslvpkal epyvtemaqg tvggvfitta gstsngtsdl
      361 tngadgmlat ssngsqysgs rvetpvsyvg eddeedddfn endedd
//
LOCUS       XP_047286524             406 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor Dp-1 isoform X4 [Homo sapiens].
ACCESSION   XP_047286524
VERSION     XP_047286524.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430568.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..406
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..406
                     /product="transcription factor Dp-1 isoform X4"
                     /calculated_mol_wt=44478
     Region          112..193
                     /region_name="E2F_TDP"
                     /note="E2F/DP family winged-helix DNA-binding domain;
                     pfam02319"
                     /db_xref="CDD:460530"
     Site            order(198,202,205..206,208..209,212..213,215..216,
                     219..220,223,226..227,230,233..234,236..237,239..241,244,
                     255..266,268,279..287,289,291,293,299..300,302)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:271217"
     Region          198..244
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:271217"
     Region          200..338
                     /region_name="DP"
                     /note="Transcription factor DP; pfam08781"
                     /db_xref="CDD:462601"
     Site            order(222,225..226,229,262,271,273,288..295,302)
                     /site_type="other"
                     /note="RbC binding site [polypeptide binding]"
                     /db_xref="CDD:271217"
     CDS             1..406
                     /gene="TFDP1"
                     /gene_synonym="DILC; Dp-1; DP1; DRTF1"
                     /coded_by="XM_047430568.1:201..1421"
                     /db_xref="GeneID:7027"
                     /db_xref="HGNC:HGNC:11749"
                     /db_xref="MIM:189902"
ORIGIN      
        1 makdagliea ngelkvfidq nlspgkgvvs lvavhpstvn plgkqllpkt fgqsnvniaq
       61 qvvigtpqrp aasntlvvgs phtpsthfas qnqpsdsspw sagkrnrkge kngkglrhfs
      121 mkvcekvqrk gttsynevad elvaefsaad nhilpnesay dqknirrrvy dalnvlmamn
      181 iiskekkeik wiglptnsaq ecqnleverq rrlerikqkq sqlqelilqq iafknlvqrn
      241 rhaeqqasrp pppnsvihlp fiivntskkt vidcsisndk feylfnfdnt feihddievl
      301 krmgmacgle sgscsaedlk marslvpkal epyvtemaqg tvggvfitta gstsngtsdl
      361 tngadgmlat ssngsqysgs rvetpvsyvg eddeedddfn endedd
//
LOCUS       XP_047286525             406 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor Dp-1 isoform X4 [Homo sapiens].
ACCESSION   XP_047286525
VERSION     XP_047286525.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430569.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..406
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..406
                     /product="transcription factor Dp-1 isoform X4"
                     /calculated_mol_wt=44478
     Region          112..193
                     /region_name="E2F_TDP"
                     /note="E2F/DP family winged-helix DNA-binding domain;
                     pfam02319"
                     /db_xref="CDD:460530"
     Site            order(198,202,205..206,208..209,212..213,215..216,
                     219..220,223,226..227,230,233..234,236..237,239..241,244,
                     255..266,268,279..287,289,291,293,299..300,302)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:271217"
     Region          198..244
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:271217"
     Region          200..338
                     /region_name="DP"
                     /note="Transcription factor DP; pfam08781"
                     /db_xref="CDD:462601"
     Site            order(222,225..226,229,262,271,273,288..295,302)
                     /site_type="other"
                     /note="RbC binding site [polypeptide binding]"
                     /db_xref="CDD:271217"
     CDS             1..406
                     /gene="TFDP1"
                     /gene_synonym="DILC; Dp-1; DP1; DRTF1"
                     /coded_by="XM_047430569.1:377..1597"
                     /db_xref="GeneID:7027"
                     /db_xref="HGNC:HGNC:11749"
                     /db_xref="MIM:189902"
ORIGIN      
        1 makdagliea ngelkvfidq nlspgkgvvs lvavhpstvn plgkqllpkt fgqsnvniaq
       61 qvvigtpqrp aasntlvvgs phtpsthfas qnqpsdsspw sagkrnrkge kngkglrhfs
      121 mkvcekvqrk gttsynevad elvaefsaad nhilpnesay dqknirrrvy dalnvlmamn
      181 iiskekkeik wiglptnsaq ecqnleverq rrlerikqkq sqlqelilqq iafknlvqrn
      241 rhaeqqasrp pppnsvihlp fiivntskkt vidcsisndk feylfnfdnt feihddievl
      301 krmgmacgle sgscsaedlk marslvpkal epyvtemaqg tvggvfitta gstsngtsdl
      361 tngadgmlat ssngsqysgs rvetpvsyvg eddeedddfn endedd
//
LOCUS       XP_047286526             406 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor Dp-1 isoform X4 [Homo sapiens].
ACCESSION   XP_047286526
VERSION     XP_047286526.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430570.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..406
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..406
                     /product="transcription factor Dp-1 isoform X4"
                     /calculated_mol_wt=44478
     Region          112..193
                     /region_name="E2F_TDP"
                     /note="E2F/DP family winged-helix DNA-binding domain;
                     pfam02319"
                     /db_xref="CDD:460530"
     Site            order(198,202,205..206,208..209,212..213,215..216,
                     219..220,223,226..227,230,233..234,236..237,239..241,244,
                     255..266,268,279..287,289,291,293,299..300,302)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:271217"
     Region          198..244
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:271217"
     Region          200..338
                     /region_name="DP"
                     /note="Transcription factor DP; pfam08781"
                     /db_xref="CDD:462601"
     Site            order(222,225..226,229,262,271,273,288..295,302)
                     /site_type="other"
                     /note="RbC binding site [polypeptide binding]"
                     /db_xref="CDD:271217"
     CDS             1..406
                     /gene="TFDP1"
                     /gene_synonym="DILC; Dp-1; DP1; DRTF1"
                     /coded_by="XM_047430570.1:201..1421"
                     /db_xref="GeneID:7027"
                     /db_xref="HGNC:HGNC:11749"
                     /db_xref="MIM:189902"
ORIGIN      
        1 makdagliea ngelkvfidq nlspgkgvvs lvavhpstvn plgkqllpkt fgqsnvniaq
       61 qvvigtpqrp aasntlvvgs phtpsthfas qnqpsdsspw sagkrnrkge kngkglrhfs
      121 mkvcekvqrk gttsynevad elvaefsaad nhilpnesay dqknirrrvy dalnvlmamn
      181 iiskekkeik wiglptnsaq ecqnleverq rrlerikqkq sqlqelilqq iafknlvqrn
      241 rhaeqqasrp pppnsvihlp fiivntskkt vidcsisndk feylfnfdnt feihddievl
      301 krmgmacgle sgscsaedlk marslvpkal epyvtemaqg tvggvfitta gstsngtsdl
      361 tngadgmlat ssngsqysgs rvetpvsyvg eddeedddfn endedd
//
LOCUS       XP_047286527             381 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor Dp-1 isoform X5 [Homo sapiens].
ACCESSION   XP_047286527
VERSION     XP_047286527.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430571.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..381
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..381
                     /product="transcription factor Dp-1 isoform X5"
                     /calculated_mol_wt=42745
     Region          17..98
                     /region_name="E2F_TDP"
                     /note="E2F/DP family winged-helix DNA-binding domain;
                     pfam02319"
                     /db_xref="CDD:460530"
     Site            order(103,107,110..111,113..114,117..118,120..121,
                     124..125,128,131..132,135,138..139,141..142,144..146,149,
                     160..171,173,184..192,194,196,198,204..205,207)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:271217"
     Region          103..149
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:271217"
     Region          105..241
                     /region_name="DP"
                     /note="Transcription factor DP; pfam08781"
                     /db_xref="CDD:462601"
     Site            order(127,130..131,134,167,176,178,193..200,207)
                     /site_type="other"
                     /note="RbC binding site [polypeptide binding]"
                     /db_xref="CDD:271217"
     CDS             1..381
                     /gene="TFDP1"
                     /gene_synonym="DILC; Dp-1; DP1; DRTF1"
                     /coded_by="XM_047430571.1:85..1230"
                     /db_xref="GeneID:7027"
                     /db_xref="HGNC:HGNC:11749"
                     /db_xref="MIM:189902"
ORIGIN      
        1 mstlpskwkr nrkgekngkg lrhfsmkvce kvqrkgttsy nevadelvae fsaadnhilp
       61 nesaydqkni rrrvydalnv lmamniiske kkeikwiglp tnsaqecqnl everqrrler
      121 ikqkqsqlqe lilqqiafkn lvqrnrhaeq qasrppppns vihlpfiivn tskktvidcs
      181 isndkfeylf nfdntfeihd dievlkrmgm acglesgscs aedlkmarsl vpkalepyvt
      241 ektglcdcta gcpapwrsve ntgqakdirk llqpsvlwnc asfcwlpvrl vlflfhdhsl
      301 iffpfsemaq gtvggvfitt agstsngtrf sasdltngad gmlatssngs qysgsrvetp
      361 vsyvgeddee dddfnended d
//
LOCUS       XP_047286528             337 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor Dp-1 isoform X6 [Homo sapiens].
ACCESSION   XP_047286528
VERSION     XP_047286528.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430572.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..337
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..337
                     /product="transcription factor Dp-1 isoform X6"
                     /calculated_mol_wt=37378
     Region          112..193
                     /region_name="E2F_TDP"
                     /note="E2F/DP family winged-helix DNA-binding domain;
                     pfam02319"
                     /db_xref="CDD:460530"
     Site            order(198,202,205..206,208..209,212..213,215..216,
                     219..220,223,226..227,230,233..234,236..237,239..241,244,
                     255..266,268,279..287,289,291,293,299..300,302)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:271217"
     Region          198..244
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:271217"
     Region          200..335
                     /region_name="DP"
                     /note="Transcription factor DP; pfam08781"
                     /db_xref="CDD:462601"
     Site            order(222,225..226,229,262,271,273,288..295,302)
                     /site_type="other"
                     /note="RbC binding site [polypeptide binding]"
                     /db_xref="CDD:271217"
     CDS             1..337
                     /gene="TFDP1"
                     /gene_synonym="DILC; Dp-1; DP1; DRTF1"
                     /coded_by="XM_047430572.1:317..1330"
                     /db_xref="GeneID:7027"
                     /db_xref="HGNC:HGNC:11749"
                     /db_xref="MIM:189902"
ORIGIN      
        1 makdagliea ngelkvfidq nlspgkgvvs lvavhpstvn plgkqllpkt fgqsnvniaq
       61 qvvigtpqrp aasntlvvgs phtpsthfas qnqpsdsspw sagkrnrkge kngkglrhfs
      121 mkvcekvqrk gttsynevad elvaefsaad nhilpnesay dqknirrrvy dalnvlmamn
      181 iiskekkeik wiglptnsaq ecqnleverq rrlerikqkq sqlqelilqq iafknlvqrn
      241 rhaeqqasrp pppnsvihlp fiivntskkt vidcsisndk feylfnfdnt feihddievl
      301 krmgmacgle sgscsaedlk marslvpkal epyvtvt
//
LOCUS       XP_016876208             337 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor Dp-1 isoform X6 [Homo sapiens].
ACCESSION   XP_016876208
VERSION     XP_016876208.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020719.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..337
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..337
                     /product="transcription factor Dp-1 isoform X6"
                     /calculated_mol_wt=37378
     Region          112..193
                     /region_name="E2F_TDP"
                     /note="E2F/DP family winged-helix DNA-binding domain;
                     pfam02319"
                     /db_xref="CDD:460530"
     Site            order(198,202,205..206,208..209,212..213,215..216,
                     219..220,223,226..227,230,233..234,236..237,239..241,244,
                     255..266,268,279..287,289,291,293,299..300,302)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:271217"
     Region          198..244
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:271217"
     Region          200..335
                     /region_name="DP"
                     /note="Transcription factor DP; pfam08781"
                     /db_xref="CDD:462601"
     Site            order(222,225..226,229,262,271,273,288..295,302)
                     /site_type="other"
                     /note="RbC binding site [polypeptide binding]"
                     /db_xref="CDD:271217"
     CDS             1..337
                     /gene="TFDP1"
                     /gene_synonym="DILC; Dp-1; DP1; DRTF1"
                     /coded_by="XM_017020719.3:108..1121"
                     /db_xref="GeneID:7027"
                     /db_xref="HGNC:HGNC:11749"
                     /db_xref="MIM:189902"
ORIGIN      
        1 makdagliea ngelkvfidq nlspgkgvvs lvavhpstvn plgkqllpkt fgqsnvniaq
       61 qvvigtpqrp aasntlvvgs phtpsthfas qnqpsdsspw sagkrnrkge kngkglrhfs
      121 mkvcekvqrk gttsynevad elvaefsaad nhilpnesay dqknirrrvy dalnvlmamn
      181 iiskekkeik wiglptnsaq ecqnleverq rrlerikqkq sqlqelilqq iafknlvqrn
      241 rhaeqqasrp pppnsvihlp fiivntskkt vidcsisndk feylfnfdnt feihddievl
      301 krmgmacgle sgscsaedlk marslvpkal epyvtvt
//
LOCUS       XP_047286529             337 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor Dp-1 isoform X6 [Homo sapiens].
ACCESSION   XP_047286529
VERSION     XP_047286529.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430573.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..337
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..337
                     /product="transcription factor Dp-1 isoform X6"
                     /calculated_mol_wt=37378
     Region          112..193
                     /region_name="E2F_TDP"
                     /note="E2F/DP family winged-helix DNA-binding domain;
                     pfam02319"
                     /db_xref="CDD:460530"
     Site            order(198,202,205..206,208..209,212..213,215..216,
                     219..220,223,226..227,230,233..234,236..237,239..241,244,
                     255..266,268,279..287,289,291,293,299..300,302)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:271217"
     Region          198..244
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:271217"
     Region          200..335
                     /region_name="DP"
                     /note="Transcription factor DP; pfam08781"
                     /db_xref="CDD:462601"
     Site            order(222,225..226,229,262,271,273,288..295,302)
                     /site_type="other"
                     /note="RbC binding site [polypeptide binding]"
                     /db_xref="CDD:271217"
     CDS             1..337
                     /gene="TFDP1"
                     /gene_synonym="DILC; Dp-1; DP1; DRTF1"
                     /coded_by="XM_047430573.1:193..1206"
                     /db_xref="GeneID:7027"
                     /db_xref="HGNC:HGNC:11749"
                     /db_xref="MIM:189902"
ORIGIN      
        1 makdagliea ngelkvfidq nlspgkgvvs lvavhpstvn plgkqllpkt fgqsnvniaq
       61 qvvigtpqrp aasntlvvgs phtpsthfas qnqpsdsspw sagkrnrkge kngkglrhfs
      121 mkvcekvqrk gttsynevad elvaefsaad nhilpnesay dqknirrrvy dalnvlmamn
      181 iiskekkeik wiglptnsaq ecqnleverq rrlerikqkq sqlqelilqq iafknlvqrn
      241 rhaeqqasrp pppnsvihlp fiivntskkt vidcsisndk feylfnfdnt feihddievl
      301 krmgmacgle sgscsaedlk marslvpkal epyvtvt
//
LOCUS       XP_047286530             337 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor Dp-1 isoform X6 [Homo sapiens].
ACCESSION   XP_047286530
VERSION     XP_047286530.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430574.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..337
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..337
                     /product="transcription factor Dp-1 isoform X6"
                     /calculated_mol_wt=37378
     Region          112..193
                     /region_name="E2F_TDP"
                     /note="E2F/DP family winged-helix DNA-binding domain;
                     pfam02319"
                     /db_xref="CDD:460530"
     Site            order(198,202,205..206,208..209,212..213,215..216,
                     219..220,223,226..227,230,233..234,236..237,239..241,244,
                     255..266,268,279..287,289,291,293,299..300,302)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:271217"
     Region          198..244
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:271217"
     Region          200..335
                     /region_name="DP"
                     /note="Transcription factor DP; pfam08781"
                     /db_xref="CDD:462601"
     Site            order(222,225..226,229,262,271,273,288..295,302)
                     /site_type="other"
                     /note="RbC binding site [polypeptide binding]"
                     /db_xref="CDD:271217"
     CDS             1..337
                     /gene="TFDP1"
                     /gene_synonym="DILC; Dp-1; DP1; DRTF1"
                     /coded_by="XM_047430574.1:89..1102"
                     /db_xref="GeneID:7027"
                     /db_xref="HGNC:HGNC:11749"
                     /db_xref="MIM:189902"
ORIGIN      
        1 makdagliea ngelkvfidq nlspgkgvvs lvavhpstvn plgkqllpkt fgqsnvniaq
       61 qvvigtpqrp aasntlvvgs phtpsthfas qnqpsdsspw sagkrnrkge kngkglrhfs
      121 mkvcekvqrk gttsynevad elvaefsaad nhilpnesay dqknirrrvy dalnvlmamn
      181 iiskekkeik wiglptnsaq ecqnleverq rrlerikqkq sqlqelilqq iafknlvqrn
      241 rhaeqqasrp pppnsvihlp fiivntskkt vidcsisndk feylfnfdnt feihddievl
      301 krmgmacgle sgscsaedlk marslvpkal epyvtvt
//
LOCUS       XP_047286531             337 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor Dp-1 isoform X6 [Homo sapiens].
ACCESSION   XP_047286531
VERSION     XP_047286531.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430575.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..337
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..337
                     /product="transcription factor Dp-1 isoform X6"
                     /calculated_mol_wt=37378
     Region          112..193
                     /region_name="E2F_TDP"
                     /note="E2F/DP family winged-helix DNA-binding domain;
                     pfam02319"
                     /db_xref="CDD:460530"
     Site            order(198,202,205..206,208..209,212..213,215..216,
                     219..220,223,226..227,230,233..234,236..237,239..241,244,
                     255..266,268,279..287,289,291,293,299..300,302)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:271217"
     Region          198..244
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:271217"
     Region          200..335
                     /region_name="DP"
                     /note="Transcription factor DP; pfam08781"
                     /db_xref="CDD:462601"
     Site            order(222,225..226,229,262,271,273,288..295,302)
                     /site_type="other"
                     /note="RbC binding site [polypeptide binding]"
                     /db_xref="CDD:271217"
     CDS             1..337
                     /gene="TFDP1"
                     /gene_synonym="DILC; Dp-1; DP1; DRTF1"
                     /coded_by="XM_047430575.1:201..1214"
                     /db_xref="GeneID:7027"
                     /db_xref="HGNC:HGNC:11749"
                     /db_xref="MIM:189902"
ORIGIN      
        1 makdagliea ngelkvfidq nlspgkgvvs lvavhpstvn plgkqllpkt fgqsnvniaq
       61 qvvigtpqrp aasntlvvgs phtpsthfas qnqpsdsspw sagkrnrkge kngkglrhfs
      121 mkvcekvqrk gttsynevad elvaefsaad nhilpnesay dqknirrrvy dalnvlmamn
      181 iiskekkeik wiglptnsaq ecqnleverq rrlerikqkq sqlqelilqq iafknlvqrn
      241 rhaeqqasrp pppnsvihlp fiivntskkt vidcsisndk feylfnfdnt feihddievl
      301 krmgmacgle sgscsaedlk marslvpkal epyvtvt
//
LOCUS       XP_047286532             315 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor Dp-1 isoform X7 [Homo sapiens].
ACCESSION   XP_047286532
VERSION     XP_047286532.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430576.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..315
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..315
                     /product="transcription factor Dp-1 isoform X7"
                     /calculated_mol_wt=35252
     Region          17..98
                     /region_name="E2F_TDP"
                     /note="E2F/DP family winged-helix DNA-binding domain;
                     pfam02319"
                     /db_xref="CDD:460530"
     Site            order(103,107,110..111,113..114,117..118,120..121,
                     124..125,128,131..132,135,138..139,141..142,144..146,149,
                     160..171,173,184..192,194,196,198,204..205,207)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:271217"
     Region          103..149
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:271217"
     Region          105..243
                     /region_name="DP"
                     /note="Transcription factor DP; pfam08781"
                     /db_xref="CDD:462601"
     Site            order(127,130..131,134,167,176,178,193..200,207)
                     /site_type="other"
                     /note="RbC binding site [polypeptide binding]"
                     /db_xref="CDD:271217"
     CDS             1..315
                     /gene="TFDP1"
                     /gene_synonym="DILC; Dp-1; DP1; DRTF1"
                     /coded_by="XM_047430576.1:85..1032"
                     /db_xref="GeneID:7027"
                     /db_xref="HGNC:HGNC:11749"
                     /db_xref="MIM:189902"
ORIGIN      
        1 mstlpskwkr nrkgekngkg lrhfsmkvce kvqrkgttsy nevadelvae fsaadnhilp
       61 nesaydqkni rrrvydalnv lmamniiske kkeikwiglp tnsaqecqnl everqrrler
      121 ikqkqsqlqe lilqqiafkn lvqrnrhaeq qasrppppns vihlpfiivn tskktvidcs
      181 isndkfeylf nfdntfeihd dievlkrmgm acglesgscs aedlkmarsl vpkalepyvt
      241 emaqgtvggv fittagstsn gtrfsasdlt ngadgmlats sngsqysgsr vetpvsyvge
      301 ddeedddfne ndedd
//
LOCUS       XP_047286533             242 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor Dp-1 isoform X8 [Homo sapiens].
ACCESSION   XP_047286533
VERSION     XP_047286533.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430577.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..242
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..242
                     /product="transcription factor Dp-1 isoform X8"
                     /calculated_mol_wt=27690
     Region          17..98
                     /region_name="E2F_TDP"
                     /note="E2F/DP family winged-helix DNA-binding domain;
                     pfam02319"
                     /db_xref="CDD:460530"
     Site            order(103,107,110..111,113..114,117..118,120..121,
                     124..125,128,131..132,135,138..139,141..142,144..146,149,
                     160..171,173,184..192,194,196,198,204..205,207)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:271217"
     Region          103..149
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:271217"
     Region          105..240
                     /region_name="DP"
                     /note="Transcription factor DP; pfam08781"
                     /db_xref="CDD:462601"
     Site            order(127,130..131,134,167,176,178,193..200,207)
                     /site_type="other"
                     /note="RbC binding site [polypeptide binding]"
                     /db_xref="CDD:271217"
     CDS             1..242
                     /gene="TFDP1"
                     /gene_synonym="DILC; Dp-1; DP1; DRTF1"
                     /coded_by="XM_047430577.1:85..813"
                     /db_xref="GeneID:7027"
                     /db_xref="HGNC:HGNC:11749"
                     /db_xref="MIM:189902"
ORIGIN      
        1 mstlpskwkr nrkgekngkg lrhfsmkvce kvqrkgttsy nevadelvae fsaadnhilp
       61 nesaydqkni rrrvydalnv lmamniiske kkeikwiglp tnsaqecqnl everqrrler
      121 ikqkqsqlqe lilqqiafkn lvqrnrhaeq qasrppppns vihlpfiivn tskktvidcs
      181 isndkfeylf nfdntfeihd dievlkrmgm acglesgscs aedlkmarsl vpkalepyvt
      241 vt
//
LOCUS       XP_047286534            1162 aa            linear   PRI 05-AUG-2025
DEFINITION  tripeptidyl-peptidase 2 isoform X2 [Homo sapiens].
ACCESSION   XP_047286534
VERSION     XP_047286534.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430578.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1162
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1162
                     /product="tripeptidyl-peptidase 2 isoform X2"
                     /calculated_mol_wt=128014
     Region          14..489
                     /region_name="Peptidases_S8_Tripeptidyl_Aminopeptidase_II"
                     /note="Peptidase S8 family domain in Tripeptidyl
                     aminopeptidases_II; cd04857"
                     /db_xref="CDD:173796"
     Site            order(44,264,449)
                     /site_type="active"
                     /note="putative catalytic triad [active]"
                     /db_xref="CDD:173796"
     Site            order(190,264,328..330,362,449)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:173796"
     Region          777..963
                     /region_name="TPPII"
                     /note="Tripeptidyl peptidase II; pfam12580"
                     /db_xref="CDD:463636"
     CDS             1..1162
                     /gene="TPP2"
                     /gene_synonym="IMD78; TPP-2; TPP-II; TPPII"
                     /coded_by="XM_047430578.1:54..3542"
                     /db_xref="GeneID:7174"
                     /db_xref="HGNC:HGNC:12016"
                     /db_xref="MIM:190470"
ORIGIN      
        1 mataateepf pfhgllpkke tgaasflcry peydgrgvli avldtgvdpg apgmqvttdg
       61 kpkivdiidt tgsgdvntat evepkdgeiv glsgrvlkip aswtnpsgky higikngydf
      121 ypkalkeriq kerkekiwdp vhrvalaeac rkqeefdvan ngssqankli keelqsqvel
      181 lnsfekkysd pgpvydclvw hdgevwraci dsnedgdlsk stvlrnykea qeygsfgtae
      241 mlnysvniyd dgnllsivts ggahgthvas iaaghfpeep erngvapgaq ilsikigdtr
      301 lstmetgtgl iramievinh kcdlvnysyg eathwpnsgr icevineavw khniiyvssa
      361 gnngpclstv gcpggttssv igvgayvspd mmvaeyslre klpanqytws srgpsadgal
      421 gvsisapgga iasvpnwtlr gtqlmngtsm sspnacggia lilsglkann idytvhsvrr
      481 alentavkad nievfaqghg iiqvdkaydy lvqntsfank lgftvtvgnn rgiylrdpvq
      541 vaapsdhgvg iepvfpente nsekislqlh laltsnsswv qcpshlelmn qcrhinirvd
      601 prglreglhy tevcgydias pnagplfrvp itaviaakvn esshydlaft dvhfkpgqir
      661 rhfievpega twaevtvcsc ssevsakfvl havqlvkqra yrshefykfc slpekgtlte
      721 afpvlggkai efciarwwas lsdvnidyti sfhgivctap qlnihasegi nrfdvqsslk
      781 yedlapcitl knwvqtlrpv saktkplgsr dvlpnnrqly emvltynfhq pksgevtpsc
      841 pllcellyes efdsqlwiif dqnkrqmgsg dayphqyslk lekgdytirl qirheqisdl
      901 erlkdlpfiv shrlsntlsl dihenhsfal lgkkkssnlt lppkynqpff vtslpddkip
      961 kgagpgcyla gsltlsktel gkkagqsaak rqgkfkkdvi pvhyylippp tktkngskdk
     1021 ekdsekekdl keeftealrd lkiqwmtkld ssdiynelke typnylplyv arlhqldaek
     1081 ermkrlneiv daanavishi dqtalavyia mktdprpdaa tikkyltscl lisasfqpfs
     1141 gqpgsirqhl pslpcrlwps dg
//
LOCUS       XP_047286535            1137 aa            linear   PRI 05-AUG-2025
DEFINITION  tripeptidyl-peptidase 2 isoform X3 [Homo sapiens].
ACCESSION   XP_047286535
VERSION     XP_047286535.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430579.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1137
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1137
                     /product="tripeptidyl-peptidase 2 isoform X3"
                     /calculated_mol_wt=125406
     Region          14..489
                     /region_name="Peptidases_S8_Tripeptidyl_Aminopeptidase_II"
                     /note="Peptidase S8 family domain in Tripeptidyl
                     aminopeptidases_II; cd04857"
                     /db_xref="CDD:173796"
     Site            order(44,264,449)
                     /site_type="active"
                     /note="putative catalytic triad [active]"
                     /db_xref="CDD:173796"
     Site            order(190,264,328..330,362,449)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:173796"
     Region          777..963
                     /region_name="TPPII"
                     /note="Tripeptidyl peptidase II; pfam12580"
                     /db_xref="CDD:463636"
     CDS             1..1137
                     /gene="TPP2"
                     /gene_synonym="IMD78; TPP-2; TPP-II; TPPII"
                     /coded_by="XM_047430579.1:54..3467"
                     /db_xref="GeneID:7174"
                     /db_xref="HGNC:HGNC:12016"
                     /db_xref="MIM:190470"
ORIGIN      
        1 mataateepf pfhgllpkke tgaasflcry peydgrgvli avldtgvdpg apgmqvttdg
       61 kpkivdiidt tgsgdvntat evepkdgeiv glsgrvlkip aswtnpsgky higikngydf
      121 ypkalkeriq kerkekiwdp vhrvalaeac rkqeefdvan ngssqankli keelqsqvel
      181 lnsfekkysd pgpvydclvw hdgevwraci dsnedgdlsk stvlrnykea qeygsfgtae
      241 mlnysvniyd dgnllsivts ggahgthvas iaaghfpeep erngvapgaq ilsikigdtr
      301 lstmetgtgl iramievinh kcdlvnysyg eathwpnsgr icevineavw khniiyvssa
      361 gnngpclstv gcpggttssv igvgayvspd mmvaeyslre klpanqytws srgpsadgal
      421 gvsisapgga iasvpnwtlr gtqlmngtsm sspnacggia lilsglkann idytvhsvrr
      481 alentavkad nievfaqghg iiqvdkaydy lvqntsfank lgftvtvgnn rgiylrdpvq
      541 vaapsdhgvg iepvfpente nsekislqlh laltsnsswv qcpshlelmn qcrhinirvd
      601 prglreglhy tevcgydias pnagplfrvp itaviaakvn esshydlaft dvhfkpgqir
      661 rhfievpega twaevtvcsc ssevsakfvl havqlvkqra yrshefykfc slpekgtlte
      721 afpvlggkai efciarwwas lsdvnidyti sfhgivctap qlnihasegi nrfdvqsslk
      781 yedlapcitl knwvqtlrpv saktkplgsr dvlpnnrqly emvltynfhq pksgevtpsc
      841 pllcellyes efdsqlwiif dqnkrqmgsg dayphqyslk lekgdytirl qirheqisdl
      901 erlkdlpfiv shrlsntlsl dihenhsfal lgkkkssnlt lppkynqpff vtslpddkip
      961 kgagpgcyla gsltlsktel gkkagqsaak rqgkfkkdvi pvhyylippp tktkngskdk
     1021 ekdsekekdl keeftealrd lkiqwmtkld ssdiynelke typnylplyv arlhqldaek
     1081 ermkrlneiv daanavishi dqtalavyia mktdprpdaa tikkyltmtw tnknpps
//
LOCUS       XP_047286536            1124 aa            linear   PRI 05-AUG-2025
DEFINITION  tripeptidyl-peptidase 2 isoform X4 [Homo sapiens].
ACCESSION   XP_047286536
VERSION     XP_047286536.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430580.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1124
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1124
                     /product="tripeptidyl-peptidase 2 isoform X4"
                     /calculated_mol_wt=123990
     Region          14..489
                     /region_name="Peptidases_S8_Tripeptidyl_Aminopeptidase_II"
                     /note="Peptidase S8 family domain in Tripeptidyl
                     aminopeptidases_II; cd04857"
                     /db_xref="CDD:173796"
     Site            order(44,264,449)
                     /site_type="active"
                     /note="putative catalytic triad [active]"
                     /db_xref="CDD:173796"
     Site            order(190,264,328..330,362,449)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:173796"
     Region          777..963
                     /region_name="TPPII"
                     /note="Tripeptidyl peptidase II; pfam12580"
                     /db_xref="CDD:463636"
     CDS             1..1124
                     /gene="TPP2"
                     /gene_synonym="IMD78; TPP-2; TPP-II; TPPII"
                     /coded_by="XM_047430580.1:54..3428"
                     /db_xref="GeneID:7174"
                     /db_xref="HGNC:HGNC:12016"
                     /db_xref="MIM:190470"
ORIGIN      
        1 mataateepf pfhgllpkke tgaasflcry peydgrgvli avldtgvdpg apgmqvttdg
       61 kpkivdiidt tgsgdvntat evepkdgeiv glsgrvlkip aswtnpsgky higikngydf
      121 ypkalkeriq kerkekiwdp vhrvalaeac rkqeefdvan ngssqankli keelqsqvel
      181 lnsfekkysd pgpvydclvw hdgevwraci dsnedgdlsk stvlrnykea qeygsfgtae
      241 mlnysvniyd dgnllsivts ggahgthvas iaaghfpeep erngvapgaq ilsikigdtr
      301 lstmetgtgl iramievinh kcdlvnysyg eathwpnsgr icevineavw khniiyvssa
      361 gnngpclstv gcpggttssv igvgayvspd mmvaeyslre klpanqytws srgpsadgal
      421 gvsisapgga iasvpnwtlr gtqlmngtsm sspnacggia lilsglkann idytvhsvrr
      481 alentavkad nievfaqghg iiqvdkaydy lvqntsfank lgftvtvgnn rgiylrdpvq
      541 vaapsdhgvg iepvfpente nsekislqlh laltsnsswv qcpshlelmn qcrhinirvd
      601 prglreglhy tevcgydias pnagplfrvp itaviaakvn esshydlaft dvhfkpgqir
      661 rhfievpega twaevtvcsc ssevsakfvl havqlvkqra yrshefykfc slpekgtlte
      721 afpvlggkai efciarwwas lsdvnidyti sfhgivctap qlnihasegi nrfdvqsslk
      781 yedlapcitl knwvqtlrpv saktkplgsr dvlpnnrqly emvltynfhq pksgevtpsc
      841 pllcellyes efdsqlwiif dqnkrqmgsg dayphqyslk lekgdytirl qirheqisdl
      901 erlkdlpfiv shrlsntlsl dihenhsfal lgkkkssnlt lppkynqpff vtslpddkip
      961 kgagpgcyla gsltlsktel gkkadvipvh yylippptkt kngskdkekd sekekdlkee
     1021 ftealrdlki qwmtkldssd iynelketyp nylplyvarl hqldaekerm krlneivdaa
     1081 navishidqt alavyiamkt dprpdaatik kyltmtwtnk npps
//
LOCUS       XP_011533508             562 aa            linear   PRI 05-AUG-2025
DEFINITION  short transient receptor potential channel 4 isoform X1 [Homo
            sapiens].
ACCESSION   XP_011533508
VERSION     XP_011533508.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535206.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..562
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..562
                     /product="short transient receptor potential channel 4
                     isoform X1"
                     /calculated_mol_wt=64220
     Region          <1..334
                     /region_name="TRPV"
                     /note="Transient Receptor Potential channel, Vanilloid
                     subfamily (TRPV); cl40437"
                     /db_xref="CDD:454755"
     CDS             1..562
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /coded_by="XM_011535206.2:116..1804"
                     /db_xref="GeneID:7223"
                     /db_xref="HGNC:HGNC:12336"
                     /db_xref="MIM:603651"
ORIGIN      
        1 mwdgglqdyi hdwwnlmdfv mnslylatis lkivafvkys alnpreswdm whptlvaeal
       61 faianifssl rlislftans hlgplqislg rmlldilkfl fiyclvllaf anglnqlyfy
      121 yeetkgltck gircekqnna fstlfetlqs lfwsifglin lyvtnvkaqh eftefvgatm
      181 fgtynvislv vllnmliamm nnsyqliadh adiewkfart klwmsyfeeg gtlptpfnvi
      241 pspkslwyli kwiwthlckk kmrrkpesfg tigvrtqhrr aadnlrrhhq yqevmrnlvk
      301 ryvaamirda kteeglteen fkelkqdiss frfevlgllr gsklstiqsa naskessnsa
      361 dsdeksdseg nskdkkknfs lfdlttlihp rsaaiaserh nisngsalvv qepprekqrk
      421 vnfvtdiknf glfhrrskqn aaeqnanqif svseevarqq aagplerniq lesrglasrg
      481 dlsipglseq cvlvdhrern tdtlglqvgk rvcpfksekv vvedtvpiip kekhakeeds
      541 sidydlnlpd tvthedyvtt rl
//
LOCUS       XP_016876212             562 aa            linear   PRI 05-AUG-2025
DEFINITION  short transient receptor potential channel 4 isoform X1 [Homo
            sapiens].
ACCESSION   XP_016876212
VERSION     XP_016876212.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020723.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..562
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..562
                     /product="short transient receptor potential channel 4
                     isoform X1"
                     /calculated_mol_wt=64220
     Region          <1..334
                     /region_name="TRPV"
                     /note="Transient Receptor Potential channel, Vanilloid
                     subfamily (TRPV); cl40437"
                     /db_xref="CDD:454755"
     CDS             1..562
                     /gene="TRPC4"
                     /gene_synonym="HTRP-4; HTRP4; TRP4"
                     /coded_by="XM_017020723.2:116..1804"
                     /db_xref="GeneID:7223"
                     /db_xref="HGNC:HGNC:12336"
                     /db_xref="MIM:603651"
ORIGIN      
        1 mwdgglqdyi hdwwnlmdfv mnslylatis lkivafvkys alnpreswdm whptlvaeal
       61 faianifssl rlislftans hlgplqislg rmlldilkfl fiyclvllaf anglnqlyfy
      121 yeetkgltck gircekqnna fstlfetlqs lfwsifglin lyvtnvkaqh eftefvgatm
      181 fgtynvislv vllnmliamm nnsyqliadh adiewkfart klwmsyfeeg gtlptpfnvi
      241 pspkslwyli kwiwthlckk kmrrkpesfg tigvrtqhrr aadnlrrhhq yqevmrnlvk
      301 ryvaamirda kteeglteen fkelkqdiss frfevlgllr gsklstiqsa naskessnsa
      361 dsdeksdseg nskdkkknfs lfdlttlihp rsaaiaserh nisngsalvv qepprekqrk
      421 vnfvtdiknf glfhrrskqn aaeqnanqif svseevarqq aagplerniq lesrglasrg
      481 dlsipglseq cvlvdhrern tdtlglqvgk rvcpfksekv vvedtvpiip kekhakeeds
      541 sidydlnlpd tvthedyvtt rl
//
LOCUS       XP_047286537             449 aa            linear   PRI 05-AUG-2025
DEFINITION  cis-aconitate decarboxylase isoform X1 [Homo sapiens].
ACCESSION   XP_047286537
VERSION     XP_047286537.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430581.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..449
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..449
                     /product="cis-aconitate decarboxylase isoform X1"
                     /calculated_mol_wt=48890
     Region          2..425
                     /region_name="PrpD"
                     /note="2-methylcitrate dehydratase PrpD [Carbohydrate
                     transport and metabolism]; COG2079"
                     /db_xref="CDD:441682"
     CDS             1..449
                     /gene="ACOD1"
                     /gene_synonym="CAD; IRG1"
                     /coded_by="XM_047430581.1:101..1450"
                     /db_xref="GeneID:730249"
                     /db_xref="HGNC:HGNC:33904"
                     /db_xref="MIM:615275"
ORIGIN      
        1 mildtlgagf lgtttevfhi asqyskiyss nisstvwgqp dirlpptyaa fvngvaihsm
       61 dfddtwhpat hpsgavlpvl talaealprs pkfsgldlll afnvgievqg rllhfakean
      121 dmpkrfhpps vvgtlgsaaa askflglsst kcrealaiav shagapmana atqtkplhig
      181 naakhgieaa flamlglqgn kqvldleagf gafyanyspk vlpsiasysw lldqqdvafk
      241 rfpahlsthw vadaaasvrk hlvaerallp tdyikrivlr ipnvqyvnrp fpvsehearh
      301 sfqyvacaml ldggitvpsf hecqinrpqv rellskvele yppdnlpsfn ilyceisvtl
      361 kdgatftdrs dtfyghwrkp lsqedleekf ranaskmlsw dtveslikiv knledledcs
      421 vlttllkgps ppevasnspa cnnsitnls
//
LOCUS       XP_011533514             294 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X1 [Homo
            sapiens].
ACCESSION   XP_011533514
VERSION     XP_011533514.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535212.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..294
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..294
                     /product="ubiquitin carboxyl-terminal hydrolase isozyme L3
                     isoform X1"
                     /calculated_mol_wt=33110
     Region          6..291
                     /region_name="Peptidase_C12_UCH_L1_L3"
                     /note="Cysteine peptidase C12 containing ubiquitin
                     carboxyl-terminal hydrolase (UCH) families L1 and L3;
                     cd09616"
                     /db_xref="CDD:187737"
     Site            order(8..13,33..36,55,95,232,234,277)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:187737"
     Site            order(8,89,93,95,232..233)
                     /site_type="inhibition"
                     /note="inhibitor binding site [chemical binding]"
                     /db_xref="CDD:187737"
     Site            order(89,95,233,248)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:187737"
     CDS             1..294
                     /gene="UCHL3"
                     /gene_synonym="UCH-L3"
                     /coded_by="XM_011535212.2:31..915"
                     /db_xref="GeneID:7347"
                     /db_xref="HGNC:HGNC:12515"
                     /db_xref="MIM:603090"
ORIGIN      
        1 megqrwlple anpevtnqfl kqlglhpnwq fvdvygmdpe llsmvprpvc avlllfpite
       61 kyevfrteee ekiksqgqdv tssvyfmkqt isnacgtigl ihaiannkdk mhfesgstlk
      121 kfleesvsms peerarylen ydairvthet sahegqtess spsssqphss hcrtkasslc
      181 hhaslpwvkr nhvgpakats pslrlrrwrp flrlpslglh svapsidekv dlhfialvhv
      241 dghlyeldgr kpfpinhget sdetlledai evckkfmerd pdelrfnaia lsaa
//
LOCUS       XP_011533515             290 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X2 [Homo
            sapiens].
ACCESSION   XP_011533515
VERSION     XP_011533515.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535213.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..290
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..290
                     /product="ubiquitin carboxyl-terminal hydrolase isozyme L3
                     isoform X2"
                     /calculated_mol_wt=32667
     Region          6..287
                     /region_name="Peptidase_C12_UCH_L1_L3"
                     /note="Cysteine peptidase C12 containing ubiquitin
                     carboxyl-terminal hydrolase (UCH) families L1 and L3;
                     cd09616"
                     /db_xref="CDD:187737"
     Site            order(8..13,29..32,51,91,228,230,273)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:187737"
     Site            order(8,85,89,91,228..229)
                     /site_type="inhibition"
                     /note="inhibitor binding site [chemical binding]"
                     /db_xref="CDD:187737"
     Site            order(85,91,229,244)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:187737"
     CDS             1..290
                     /gene="UCHL3"
                     /gene_synonym="UCH-L3"
                     /coded_by="XM_011535213.3:31..903"
                     /db_xref="GeneID:7347"
                     /db_xref="HGNC:HGNC:12515"
                     /db_xref="MIM:603090"
ORIGIN      
        1 megqrwlple anpeflkqlg lhpnwqfvdv ygmdpellsm vprpvcavll lfpitekyev
       61 frteeeekik sqgqdvtssv yfmkqtisna cgtiglihai annkdkmhfe sgstlkkfle
      121 esvsmspeer arylenydai rvthetsahe gqtessspss sqphsshcrt kasslchhas
      181 lpwvkrnhvg pakatspslr lrrwrpflrl pslglhsvap sidekvdlhf ialvhvdghl
      241 yeldgrkpfp inhgetsdet lledaievck kfmerdpdel rfnaialsaa
//
LOCUS       XP_016876214             261 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X3 [Homo
            sapiens].
ACCESSION   XP_016876214
VERSION     XP_016876214.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020725.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..261
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..261
                     /product="ubiquitin carboxyl-terminal hydrolase isozyme L3
                     isoform X3"
                     /calculated_mol_wt=29378
     Region          6..>247
                     /region_name="Peptidase_C12_UCH_L1_L3"
                     /note="Cysteine peptidase C12 containing ubiquitin
                     carboxyl-terminal hydrolase (UCH) families L1 and L3;
                     cd09616"
                     /db_xref="CDD:187737"
     Site            order(8..13,33..36,55,95,232,234)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:187737"
     Site            order(8,89,93,95,232..233)
                     /site_type="inhibition"
                     /note="inhibitor binding site [chemical binding]"
                     /db_xref="CDD:187737"
     CDS             1..261
                     /gene="UCHL3"
                     /gene_synonym="UCH-L3"
                     /coded_by="XM_017020725.2:31..816"
                     /db_xref="GeneID:7347"
                     /db_xref="HGNC:HGNC:12515"
                     /db_xref="MIM:603090"
ORIGIN      
        1 megqrwlple anpevtnqfl kqlglhpnwq fvdvygmdpe llsmvprpvc avlllfpite
       61 kyevfrteee ekiksqgqdv tssvyfmkqt isnacgtigl ihaiannkdk mhfesgstlk
      121 kfleesvsms peerarylen ydairvthet sahegqtess spsssqphss hcrtkasslc
      181 hhaslpwvkr nhvgpakats pslrlrrwrp flrlpslglh svapsidekv dlhfialvhv
      241 dghlyelgnf hshpnlqqpp s
//
LOCUS       XP_011533516             258 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X4 [Homo
            sapiens].
ACCESSION   XP_011533516
VERSION     XP_011533516.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535214.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..258
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..258
                     /product="ubiquitin carboxyl-terminal hydrolase isozyme L3
                     isoform X4"
                     /calculated_mol_wt=28872
     Region          1..255
                     /region_name="Peptidase_C12_UCH_L1_L3"
                     /note="Cysteine peptidase C12 containing ubiquitin
                     carboxyl-terminal hydrolase (UCH) families L1 and L3;
                     cd09616"
                     /db_xref="CDD:187737"
     Site            order(53,59,197,212)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:187737"
     Site            order(53,57,59,196..197)
                     /site_type="inhibition"
                     /note="inhibitor binding site [chemical binding]"
                     /db_xref="CDD:187737"
     CDS             1..258
                     /gene="UCHL3"
                     /gene_synonym="UCH-L3"
                     /coded_by="XM_011535214.3:236..1012"
                     /db_xref="GeneID:7347"
                     /db_xref="HGNC:HGNC:12515"
                     /db_xref="MIM:603090"
ORIGIN      
        1 mdpellsmvp rpvcavlllf pitekyevfr teeeekiksq gqdvtssvyf mkqtisnacg
       61 tiglihaian nkdkmhfesg stlkkflees vsmspeerar ylenydairv thetsahegq
      121 tessspsssq phsshcrtka sslchhaslp wvkrnhvgpa katspslrlr rwrpflrlps
      181 lglhsvapsi dekvdlhfia lvhvdghlye ldgrkpfpin hgetsdetll edaievckkf
      241 merdpdelrf naialsaa
//
LOCUS       XP_016876215             252 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X5 [Homo
            sapiens].
ACCESSION   XP_016876215
VERSION     XP_016876215.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020726.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..252
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..252
                     /product="ubiquitin carboxyl-terminal hydrolase isozyme L3
                     isoform X5"
                     /calculated_mol_wt=28454
     Region          6..248
                     /region_name="Peptidase_C12_UCH_L1_L3"
                     /note="Cysteine peptidase C12 containing ubiquitin
                     carboxyl-terminal hydrolase (UCH) families L1 and L3;
                     cd09616"
                     /db_xref="CDD:187737"
     Site            order(8..13,33..36,55,95,232,234)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:187737"
     Site            order(8,89,93,95,232..233)
                     /site_type="inhibition"
                     /note="inhibitor binding site [chemical binding]"
                     /db_xref="CDD:187737"
     Site            order(89,95,233,248)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:187737"
     CDS             1..252
                     /gene="UCHL3"
                     /gene_synonym="UCH-L3"
                     /coded_by="XM_017020726.2:31..789"
                     /db_xref="GeneID:7347"
                     /db_xref="HGNC:HGNC:12515"
                     /db_xref="MIM:603090"
ORIGIN      
        1 megqrwlple anpevtnqfl kqlglhpnwq fvdvygmdpe llsmvprpvc avlllfpite
       61 kyevfrteee ekiksqgqdv tssvyfmkqt isnacgtigl ihaiannkdk mhfesgstlk
      121 kfleesvsms peerarylen ydairvthet sahegqtess spsssqphss hcrtkasslc
      181 hhaslpwvkr nhvgpakats pslrlrrwrp flrlpslglh svapsidekv dlhfialvhv
      241 dghlyeldll ef
//
LOCUS       XP_016876216             226 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X6 [Homo
            sapiens].
ACCESSION   XP_016876216
VERSION     XP_016876216.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020727.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..226
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..226
                     /product="ubiquitin carboxyl-terminal hydrolase isozyme L3
                     isoform X6"
                     /calculated_mol_wt=25609
     Region          6..223
                     /region_name="Peptidase_C12_UCH_L1_L3"
                     /note="Cysteine peptidase C12 containing ubiquitin
                     carboxyl-terminal hydrolase (UCH) families L1 and L3;
                     cd09616"
                     /db_xref="CDD:187737"
     Site            order(8..13,29..32,51,91,164,166,209)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:187737"
     Site            order(8,85,89,91,164..165)
                     /site_type="inhibition"
                     /note="inhibitor binding site [chemical binding]"
                     /db_xref="CDD:187737"
     Site            order(85,91,165,180)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:187737"
     CDS             1..226
                     /gene="UCHL3"
                     /gene_synonym="UCH-L3"
                     /coded_by="XM_017020727.2:31..711"
                     /db_xref="GeneID:7347"
                     /db_xref="HGNC:HGNC:12515"
                     /db_xref="MIM:603090"
ORIGIN      
        1 megqrwlple anpeflkqlg lhpnwqfvdv ygmdpellsm vprpvcavll lfpitekyev
       61 frteeeekik sqgqdvtssv yfmkqtisna cgtiglihai annkdkmhfe sgstlkkfle
      121 esvsmspeer arylenydai rvthetsahe gqteapside kvdlhfialv hvdghlyeld
      181 grkpfpinhg etsdetlled aievckkfme rdpdelrfna ialsaa
//
LOCUS       XP_047286538             197 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X7 [Homo
            sapiens].
ACCESSION   XP_047286538
VERSION     XP_047286538.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430582.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..197
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..197
                     /product="ubiquitin carboxyl-terminal hydrolase isozyme L3
                     isoform X7"
                     /calculated_mol_wt=22320
     Region          6..>183
                     /region_name="Peptidase_C12_UCH_L1_L3"
                     /note="Cysteine peptidase C12 containing ubiquitin
                     carboxyl-terminal hydrolase (UCH) families L1 and L3;
                     cd09616"
                     /db_xref="CDD:187737"
     Site            order(8..13,33..36,55,95,168,170)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:187737"
     Site            order(8,89,93,95,168..169)
                     /site_type="inhibition"
                     /note="inhibitor binding site [chemical binding]"
                     /db_xref="CDD:187737"
     CDS             1..197
                     /gene="UCHL3"
                     /gene_synonym="UCH-L3"
                     /coded_by="XM_047430582.1:31..624"
                     /db_xref="GeneID:7347"
                     /db_xref="HGNC:HGNC:12515"
                     /db_xref="MIM:603090"
ORIGIN      
        1 megqrwlple anpevtnqfl kqlglhpnwq fvdvygmdpe llsmvprpvc avlllfpite
       61 kyevfrteee ekiksqgqdv tssvyfmkqt isnacgtigl ihaiannkdk mhfesgstlk
      121 kfleesvsms peerarylen ydairvthet sahegqteap sidekvdlhf ialvhvdghl
      181 yelgnfhshp nlqqpps
//
LOCUS       XP_047286539             188 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X8 [Homo
            sapiens].
ACCESSION   XP_047286539
VERSION     XP_047286539.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430583.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..188
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..188
                     /product="ubiquitin carboxyl-terminal hydrolase isozyme L3
                     isoform X8"
                     /calculated_mol_wt=21396
     Region          6..184
                     /region_name="Peptidase_C12_UCH_L1_L3"
                     /note="Cysteine peptidase C12 containing ubiquitin
                     carboxyl-terminal hydrolase (UCH) families L1 and L3;
                     cd09616"
                     /db_xref="CDD:187737"
     Site            order(8..13,33..36,55,95,168,170)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:187737"
     Site            order(8,89,93,95,168..169)
                     /site_type="inhibition"
                     /note="inhibitor binding site [chemical binding]"
                     /db_xref="CDD:187737"
     Site            order(89,95,169,184)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:187737"
     CDS             1..188
                     /gene="UCHL3"
                     /gene_synonym="UCH-L3"
                     /coded_by="XM_047430583.1:31..597"
                     /db_xref="GeneID:7347"
                     /db_xref="HGNC:HGNC:12515"
                     /db_xref="MIM:603090"
ORIGIN      
        1 megqrwlple anpevtnqfl kqlglhpnwq fvdvygmdpe llsmvprpvc avlllfpite
       61 kyevfrteee ekiksqgqdv tssvyfmkqt isnacgtigl ihaiannkdk mhfesgstlk
      121 kfleesvsms peerarylen ydairvthet sahegqteap sidekvdlhf ialvhvdghl
      181 yeldllef
//
LOCUS       XP_047286540            1499 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger MYM-type protein 2 isoform X1 [Homo sapiens].
ACCESSION   XP_047286540
VERSION     XP_047286540.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430584.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1499
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1499
                     /product="zinc finger MYM-type protein 2 isoform X1"
                     /calculated_mol_wt=168131
     Region          449..485
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          490..531
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          542..578
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          584..624
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          653..692
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          756..793
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          844..880
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          886..921
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          1314..1482
                     /region_name="DUF3504"
                     /note="Domain of unknown function (DUF3504); pfam12012"
                     /db_xref="CDD:463430"
     CDS             1..1499
                     /gene="ZMYM2"
                     /gene_synonym="FIM; MYM; NECRC; RAMP; SCLL; ZNF198"
                     /coded_by="XM_047430584.1:1941..6440"
                     /db_xref="GeneID:7750"
                     /db_xref="HGNC:HGNC:12989"
                     /db_xref="MIM:602221"
ORIGIN      
        1 mtdastlild fpasrmamvs dnreiekspi hlggkitnil scnptknrqg etkatslpsl
       61 reswkwfstm tsaeddqesp salsgaslae seeentpipy mcillsavvt wipsldllvf
      121 fgmdtssvgg leltdqtpvl lgstamatsl tnvgnsfsgp anplvsrsnk fqnssveddd
      181 dvvfiepvqp pppsvpvvad qrtitftssk neelqgndsk itpsskelas qkgsvsetiv
      241 iddeedmetn qgqeknssnf ierrppetkn rtndvdfsts sfsrskvnag mgnsgittep
      301 dseiqianvt tletgvssvn dgqlentdgr dmnlmithvt slqntnlgdv snglqssnfg
      361 vniqtytpsl tsqtktgvgp fnpgrmnvag dvfqngesat hhnpdswisq sasfprnqkq
      421 pgvdslspva slpkqifqps vqqqptkpvk vtcanckkpl qkgqtayqrk gsahlfcstt
      481 clssfshkpa pkklcvmckk dittmkgtiv aqvdssesfq efcstsclsl yedkqnptkg
      541 alnksrctic gklteirhev sfknmthklc sdhcfnryrm anglimncce qcgeylpskg
      601 agnnvlvidg qqkrfccqsc vseykqvgsh psflkevrdh mqdsflmqpe kygklttctg
      661 crtqcrffdm tqcigpngym epycstacmn shktkyaksq slgiichfck rnslpqyqat
      721 mpdgklynfc nsscvakfqa lsmqsspngq fvapsdiqlk cnycknsfcs kpeilewenk
      781 vhqfcsktcs ddykklhciv tyceycqeek tlhetvnfsg vkrpfcsegc kllykqdfar
      841 rlglrcvtcn ycsqlckkga tkeldgvvrd fcsedcckkf qdwyykaarc dccksqgtlk
      901 ervqwrgemk hfcdqhcllr fycqqnepnm ttqkgpenlh ydqgcqtsrt kmtgsappps
      961 ptpnkemknk avlckpltmt katyckphmq tkscqtddtw rteyvpvpip vpvyipvpmh
     1021 mysqnipvpt tvpvpvpvpv flpapldsse kipaaieelk skvssdaldt elltmtdmms
     1081 edegktettn insviietdi igsdllknsd petqssmpdv pyepdldiei dfpraaeeld
     1141 menefllppv fgeeyeeqpr prskkkgakr kavsgyqshd dssdnsecsf pfkytygvna
     1201 wkhwvktrql dedllvldel kssksvklke dllshttael nyglahfvne irrpngenya
     1261 pdsiyylclg iqeylcgsnr kdnifidpgy qtfeqelnki lrswqpsilp dgsifsrvee
     1321 dylwrikqlg shspvallnt lfyfntkyfg lktveqhlrl sfgtvfrhwk knpltmenka
     1381 clryqvsslc gtdnedkitt gkrkheddep vfeqientan psrcpvkmfe cylskspqnl
     1441 nqrmdvfylq pecssstdsp vwytstsldr ntlenmlvrv llvkdiydkd nyeldedtd
//
LOCUS       XP_047286541            1499 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger MYM-type protein 2 isoform X1 [Homo sapiens].
ACCESSION   XP_047286541
VERSION     XP_047286541.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430585.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1499
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1499
                     /product="zinc finger MYM-type protein 2 isoform X1"
                     /calculated_mol_wt=168131
     Region          449..485
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          490..531
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          542..578
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          584..624
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          653..692
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          756..793
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          844..880
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          886..921
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          1314..1482
                     /region_name="DUF3504"
                     /note="Domain of unknown function (DUF3504); pfam12012"
                     /db_xref="CDD:463430"
     CDS             1..1499
                     /gene="ZMYM2"
                     /gene_synonym="FIM; MYM; NECRC; RAMP; SCLL; ZNF198"
                     /coded_by="XM_047430585.1:1830..6329"
                     /db_xref="GeneID:7750"
                     /db_xref="HGNC:HGNC:12989"
                     /db_xref="MIM:602221"
ORIGIN      
        1 mtdastlild fpasrmamvs dnreiekspi hlggkitnil scnptknrqg etkatslpsl
       61 reswkwfstm tsaeddqesp salsgaslae seeentpipy mcillsavvt wipsldllvf
      121 fgmdtssvgg leltdqtpvl lgstamatsl tnvgnsfsgp anplvsrsnk fqnssveddd
      181 dvvfiepvqp pppsvpvvad qrtitftssk neelqgndsk itpsskelas qkgsvsetiv
      241 iddeedmetn qgqeknssnf ierrppetkn rtndvdfsts sfsrskvnag mgnsgittep
      301 dseiqianvt tletgvssvn dgqlentdgr dmnlmithvt slqntnlgdv snglqssnfg
      361 vniqtytpsl tsqtktgvgp fnpgrmnvag dvfqngesat hhnpdswisq sasfprnqkq
      421 pgvdslspva slpkqifqps vqqqptkpvk vtcanckkpl qkgqtayqrk gsahlfcstt
      481 clssfshkpa pkklcvmckk dittmkgtiv aqvdssesfq efcstsclsl yedkqnptkg
      541 alnksrctic gklteirhev sfknmthklc sdhcfnryrm anglimncce qcgeylpskg
      601 agnnvlvidg qqkrfccqsc vseykqvgsh psflkevrdh mqdsflmqpe kygklttctg
      661 crtqcrffdm tqcigpngym epycstacmn shktkyaksq slgiichfck rnslpqyqat
      721 mpdgklynfc nsscvakfqa lsmqsspngq fvapsdiqlk cnycknsfcs kpeilewenk
      781 vhqfcsktcs ddykklhciv tyceycqeek tlhetvnfsg vkrpfcsegc kllykqdfar
      841 rlglrcvtcn ycsqlckkga tkeldgvvrd fcsedcckkf qdwyykaarc dccksqgtlk
      901 ervqwrgemk hfcdqhcllr fycqqnepnm ttqkgpenlh ydqgcqtsrt kmtgsappps
      961 ptpnkemknk avlckpltmt katyckphmq tkscqtddtw rteyvpvpip vpvyipvpmh
     1021 mysqnipvpt tvpvpvpvpv flpapldsse kipaaieelk skvssdaldt elltmtdmms
     1081 edegktettn insviietdi igsdllknsd petqssmpdv pyepdldiei dfpraaeeld
     1141 menefllppv fgeeyeeqpr prskkkgakr kavsgyqshd dssdnsecsf pfkytygvna
     1201 wkhwvktrql dedllvldel kssksvklke dllshttael nyglahfvne irrpngenya
     1261 pdsiyylclg iqeylcgsnr kdnifidpgy qtfeqelnki lrswqpsilp dgsifsrvee
     1321 dylwrikqlg shspvallnt lfyfntkyfg lktveqhlrl sfgtvfrhwk knpltmenka
     1381 clryqvsslc gtdnedkitt gkrkheddep vfeqientan psrcpvkmfe cylskspqnl
     1441 nqrmdvfylq pecssstdsp vwytstsldr ntlenmlvrv llvkdiydkd nyeldedtd
//
LOCUS       XP_047286543            1399 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger MYM-type protein 2 isoform X2 [Homo sapiens].
ACCESSION   XP_047286543
VERSION     XP_047286543.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430587.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 2% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1399
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1399
                     /product="zinc finger MYM-type protein 2 isoform X2"
                     /calculated_mol_wt=157201
     Region          349..385
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          390..431
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          442..478
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          484..524
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          553..592
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          656..693
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          744..780
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          786..821
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          1214..1382
                     /region_name="DUF3504"
                     /note="Domain of unknown function (DUF3504); pfam12012"
                     /db_xref="CDD:463430"
     CDS             1..1399
                     /gene="ZMYM2"
                     /gene_synonym="FIM; MYM; NECRC; RAMP; SCLL; ZNF198"
                     /coded_by="XM_047430587.1:309..4508"
                     /db_xref="GeneID:7750"
                     /db_xref="HGNC:HGNC:12989"
                     /db_xref="MIM:602221"
ORIGIN      
        1 mcillsavvt wipsldllvf fgmdtssvgg leltdqtpvl lgstamatsl tnvgnsfsgp
       61 anplvsrsnk fqnssveddd dvvfiepvqp pppsvpvvad qrtitftssk neelqgndsk
      121 itpsskelas qkgsvsetiv iddeedmetn qgqeknssnf ierrppetkn rtndvdfsts
      181 sfsrskvnag mgnsgittep dseiqianvt tletgvssvn dgqlentdgr dmnlmithvt
      241 slqntnlgdv snglqssnfg vniqtytpsl tsqtktgvgp fnpgrmnvag dvfqngesat
      301 hhnpdswisq sasfprnqkq pgvdslspva slpkqifqps vqqqptkpvk vtcanckkpl
      361 qkgqtayqrk gsahlfcstt clssfshkpa pkklcvmckk dittmkgtiv aqvdssesfq
      421 efcstsclsl yedkqnptkg alnksrctic gklteirhev sfknmthklc sdhcfnryrm
      481 anglimncce qcgeylpskg agnnvlvidg qqkrfccqsc vseykqvgsh psflkevrdh
      541 mqdsflmqpe kygklttctg crtqcrffdm tqcigpngym epycstacmn shktkyaksq
      601 slgiichfck rnslpqyqat mpdgklynfc nsscvakfqa lsmqsspngq fvapsdiqlk
      661 cnycknsfcs kpeilewenk vhqfcsktcs ddykklhciv tyceycqeek tlhetvnfsg
      721 vkrpfcsegc kllykqdfar rlglrcvtcn ycsqlckkga tkeldgvvrd fcsedcckkf
      781 qdwyykaarc dccksqgtlk ervqwrgemk hfcdqhcllr fycqqnepnm ttqkgpenlh
      841 ydqgcqtsrt kmtgsappps ptpnkemknk avlckpltmt katyckphmq tkscqtddtw
      901 rteyvpvpip vpvyipvpmh mysqnipvpt tvpvpvpvpv flpapldsse kipaaieelk
      961 skvssdaldt elltmtdmms edegktettn insviietdi igsdllknsd petqssmpdv
     1021 pyepdldiei dfpraaeeld menefllppv fgeeyeeqpr prskkkgakr kavsgyqshd
     1081 dssdnsecsf pfkytygvna wkhwvktrql dedllvldel kssksvklke dllshttael
     1141 nyglahfvne irrpngenya pdsiyylclg iqeylcgsnr kdnifidpgy qtfeqelnki
     1201 lrswqpsilp dgsifsrvee dylwrikqlg shspvallnt lfyfntkyfg lktveqhlrl
     1261 sfgtvfrhwk knpltmenka clryqvsslc gtdnedkitt gkrkheddep vfeqientan
     1321 psrcpvkmfe cylskspqnl nqrmdvfylq pecssstdsp vwytstsldr ntlenmlvrv
     1381 llvkdiydkd nyeldedtd
//
LOCUS       XP_047286544            1377 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger MYM-type protein 2 isoform X3 [Homo sapiens].
ACCESSION   XP_047286544
VERSION     XP_047286544.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430588.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1377
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1377
                     /product="zinc finger MYM-type protein 2 isoform X3"
                     /calculated_mol_wt=154781
     Region          327..363
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          368..409
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          420..456
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          462..502
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          531..570
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          634..671
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          722..758
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          764..799
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          1192..1360
                     /region_name="DUF3504"
                     /note="Domain of unknown function (DUF3504); pfam12012"
                     /db_xref="CDD:463430"
     CDS             1..1377
                     /gene="ZMYM2"
                     /gene_synonym="FIM; MYM; NECRC; RAMP; SCLL; ZNF198"
                     /coded_by="XM_047430588.1:178..4311"
                     /db_xref="GeneID:7750"
                     /db_xref="HGNC:HGNC:12989"
                     /db_xref="MIM:602221"
ORIGIN      
        1 mdtssvggle ltdqtpvllg stamatsltn vgnsfsgpan plvsrsnkfq nssveddddv
       61 vfiepvqppp psvpvvadqr titftsskne elqgndskit psskelasqk gsvsetivid
      121 deedmetnqg qeknssnfie rrppetknrt ndvdfstssf srskvnagmg nsgittepds
      181 eiqianvttl etgvssvndg qlentdgrdm nlmithvtsl qntnlgdvsn glqssnfgvn
      241 iqtytpslts qtktgvgpfn pgrmnvagdv fqngesathh npdswisqsa sfprnqkqpg
      301 vdslspvasl pkqifqpsvq qqptkpvkvt canckkplqk gqtayqrkgs ahlfcsttcl
      361 ssfshkpapk klcvmckkdi ttmkgtivaq vdssesfqef cstsclslye dkqnptkgal
      421 nksrcticgk lteirhevsf knmthklcsd hcfnryrman glimncceqc geylpskgag
      481 nnvlvidgqq krfccqscvs eykqvgshps flkevrdhmq dsflmqpeky gklttctgcr
      541 tqcrffdmtq cigpngymep ycstacmnsh ktkyaksqsl giichfckrn slpqyqatmp
      601 dgklynfcns scvakfqals mqsspngqfv apsdiqlkcn ycknsfcskp eilewenkvh
      661 qfcsktcsdd ykklhcivty ceycqeektl hetvnfsgvk rpfcsegckl lykqdfarrl
      721 glrcvtcnyc sqlckkgatk eldgvvrdfc sedcckkfqd wyykaarcdc cksqgtlker
      781 vqwrgemkhf cdqhcllrfy cqqnepnmtt qkgpenlhyd qgcqtsrtkm tgsapppspt
      841 pnkemknkav lckpltmtka tyckphmqtk scqtddtwrt eyvpvpipvp vyipvpmhmy
      901 sqnipvpttv pvpvpvpvfl papldsseki paaieelksk vssdaldtel ltmtdmmsed
      961 egktettnin sviietdiig sdllknsdpe tqssmpdvpy epdldieidf praaeeldme
     1021 nefllppvfg eeyeeqprpr skkkgakrka vsgyqshdds sdnsecsfpf kytygvnawk
     1081 hwvktrqlde dllvldelks sksvklkedl lshttaelny glahfvneir rpngenyapd
     1141 siyylclgiq eylcgsnrkd nifidpgyqt feqelnkilr swqpsilpdg sifsrveedy
     1201 lwrikqlgsh spvallntlf yfntkyfglk tveqhlrlsf gtvfrhwkkn pltmenkacl
     1261 ryqvsslcgt dnedkittgk rkheddepvf eqientanps rcpvkmfecy lskspqnlnq
     1321 rmdvfylqpe cssstdspvw ytstsldrnt lenmlvrvll vkdiydkdny eldedtd
//
LOCUS       XP_047286545            1377 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger MYM-type protein 2 isoform X3 [Homo sapiens].
ACCESSION   XP_047286545
VERSION     XP_047286545.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430589.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1377
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1377
                     /product="zinc finger MYM-type protein 2 isoform X3"
                     /calculated_mol_wt=154781
     Region          327..363
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          368..409
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          420..456
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          462..502
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          531..570
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          634..671
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          722..758
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          764..799
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          1192..1360
                     /region_name="DUF3504"
                     /note="Domain of unknown function (DUF3504); pfam12012"
                     /db_xref="CDD:463430"
     CDS             1..1377
                     /gene="ZMYM2"
                     /gene_synonym="FIM; MYM; NECRC; RAMP; SCLL; ZNF198"
                     /coded_by="XM_047430589.1:144..4277"
                     /db_xref="GeneID:7750"
                     /db_xref="HGNC:HGNC:12989"
                     /db_xref="MIM:602221"
ORIGIN      
        1 mdtssvggle ltdqtpvllg stamatsltn vgnsfsgpan plvsrsnkfq nssveddddv
       61 vfiepvqppp psvpvvadqr titftsskne elqgndskit psskelasqk gsvsetivid
      121 deedmetnqg qeknssnfie rrppetknrt ndvdfstssf srskvnagmg nsgittepds
      181 eiqianvttl etgvssvndg qlentdgrdm nlmithvtsl qntnlgdvsn glqssnfgvn
      241 iqtytpslts qtktgvgpfn pgrmnvagdv fqngesathh npdswisqsa sfprnqkqpg
      301 vdslspvasl pkqifqpsvq qqptkpvkvt canckkplqk gqtayqrkgs ahlfcsttcl
      361 ssfshkpapk klcvmckkdi ttmkgtivaq vdssesfqef cstsclslye dkqnptkgal
      421 nksrcticgk lteirhevsf knmthklcsd hcfnryrman glimncceqc geylpskgag
      481 nnvlvidgqq krfccqscvs eykqvgshps flkevrdhmq dsflmqpeky gklttctgcr
      541 tqcrffdmtq cigpngymep ycstacmnsh ktkyaksqsl giichfckrn slpqyqatmp
      601 dgklynfcns scvakfqals mqsspngqfv apsdiqlkcn ycknsfcskp eilewenkvh
      661 qfcsktcsdd ykklhcivty ceycqeektl hetvnfsgvk rpfcsegckl lykqdfarrl
      721 glrcvtcnyc sqlckkgatk eldgvvrdfc sedcckkfqd wyykaarcdc cksqgtlker
      781 vqwrgemkhf cdqhcllrfy cqqnepnmtt qkgpenlhyd qgcqtsrtkm tgsapppspt
      841 pnkemknkav lckpltmtka tyckphmqtk scqtddtwrt eyvpvpipvp vyipvpmhmy
      901 sqnipvpttv pvpvpvpvfl papldsseki paaieelksk vssdaldtel ltmtdmmsed
      961 egktettnin sviietdiig sdllknsdpe tqssmpdvpy epdldieidf praaeeldme
     1021 nefllppvfg eeyeeqprpr skkkgakrka vsgyqshdds sdnsecsfpf kytygvnawk
     1081 hwvktrqlde dllvldelks sksvklkedl lshttaelny glahfvneir rpngenyapd
     1141 siyylclgiq eylcgsnrkd nifidpgyqt feqelnkilr swqpsilpdg sifsrveedy
     1201 lwrikqlgsh spvallntlf yfntkyfglk tveqhlrlsf gtvfrhwkkn pltmenkacl
     1261 ryqvsslcgt dnedkittgk rkheddepvf eqientanps rcpvkmfecy lskspqnlnq
     1321 rmdvfylqpe cssstdspvw ytstsldrnt lenmlvrvll vkdiydkdny eldedtd
//
LOCUS       XP_047286546            1377 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger MYM-type protein 2 isoform X3 [Homo sapiens].
ACCESSION   XP_047286546
VERSION     XP_047286546.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430590.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1377
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1377
                     /product="zinc finger MYM-type protein 2 isoform X3"
                     /calculated_mol_wt=154781
     Region          327..363
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          368..409
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          420..456
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          462..502
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          531..570
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          634..671
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          722..758
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          764..799
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          1192..1360
                     /region_name="DUF3504"
                     /note="Domain of unknown function (DUF3504); pfam12012"
                     /db_xref="CDD:463430"
     CDS             1..1377
                     /gene="ZMYM2"
                     /gene_synonym="FIM; MYM; NECRC; RAMP; SCLL; ZNF198"
                     /coded_by="XM_047430590.1:418..4551"
                     /db_xref="GeneID:7750"
                     /db_xref="HGNC:HGNC:12989"
                     /db_xref="MIM:602221"
ORIGIN      
        1 mdtssvggle ltdqtpvllg stamatsltn vgnsfsgpan plvsrsnkfq nssveddddv
       61 vfiepvqppp psvpvvadqr titftsskne elqgndskit psskelasqk gsvsetivid
      121 deedmetnqg qeknssnfie rrppetknrt ndvdfstssf srskvnagmg nsgittepds
      181 eiqianvttl etgvssvndg qlentdgrdm nlmithvtsl qntnlgdvsn glqssnfgvn
      241 iqtytpslts qtktgvgpfn pgrmnvagdv fqngesathh npdswisqsa sfprnqkqpg
      301 vdslspvasl pkqifqpsvq qqptkpvkvt canckkplqk gqtayqrkgs ahlfcsttcl
      361 ssfshkpapk klcvmckkdi ttmkgtivaq vdssesfqef cstsclslye dkqnptkgal
      421 nksrcticgk lteirhevsf knmthklcsd hcfnryrman glimncceqc geylpskgag
      481 nnvlvidgqq krfccqscvs eykqvgshps flkevrdhmq dsflmqpeky gklttctgcr
      541 tqcrffdmtq cigpngymep ycstacmnsh ktkyaksqsl giichfckrn slpqyqatmp
      601 dgklynfcns scvakfqals mqsspngqfv apsdiqlkcn ycknsfcskp eilewenkvh
      661 qfcsktcsdd ykklhcivty ceycqeektl hetvnfsgvk rpfcsegckl lykqdfarrl
      721 glrcvtcnyc sqlckkgatk eldgvvrdfc sedcckkfqd wyykaarcdc cksqgtlker
      781 vqwrgemkhf cdqhcllrfy cqqnepnmtt qkgpenlhyd qgcqtsrtkm tgsapppspt
      841 pnkemknkav lckpltmtka tyckphmqtk scqtddtwrt eyvpvpipvp vyipvpmhmy
      901 sqnipvpttv pvpvpvpvfl papldsseki paaieelksk vssdaldtel ltmtdmmsed
      961 egktettnin sviietdiig sdllknsdpe tqssmpdvpy epdldieidf praaeeldme
     1021 nefllppvfg eeyeeqprpr skkkgakrka vsgyqshdds sdnsecsfpf kytygvnawk
     1081 hwvktrqlde dllvldelks sksvklkedl lshttaelny glahfvneir rpngenyapd
     1141 siyylclgiq eylcgsnrkd nifidpgyqt feqelnkilr swqpsilpdg sifsrveedy
     1201 lwrikqlgsh spvallntlf yfntkyfglk tveqhlrlsf gtvfrhwkkn pltmenkacl
     1261 ryqvsslcgt dnedkittgk rkheddepvf eqientanps rcpvkmfecy lskspqnlnq
     1321 rmdvfylqpe cssstdspvw ytstsldrnt lenmlvrvll vkdiydkdny eldedtd
//
LOCUS       XP_047286548            1312 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger MYM-type protein 2 isoform X4 [Homo sapiens].
ACCESSION   XP_047286548
VERSION     XP_047286548.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430592.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1312
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1312
                     /product="zinc finger MYM-type protein 2 isoform X4"
                     /calculated_mol_wt=148102
     Region          262..298
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          303..344
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          355..391
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          397..437
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          466..505
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          569..606
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          657..693
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          699..734
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          1127..1295
                     /region_name="DUF3504"
                     /note="Domain of unknown function (DUF3504); pfam12012"
                     /db_xref="CDD:463430"
     CDS             1..1312
                     /gene="ZMYM2"
                     /gene_synonym="FIM; MYM; NECRC; RAMP; SCLL; ZNF198"
                     /coded_by="XM_047430592.1:121..4059"
                     /db_xref="GeneID:7750"
                     /db_xref="HGNC:HGNC:12989"
                     /db_xref="MIM:602221"
ORIGIN      
        1 mcillsavvt wipsldllvf fgmdtssvgg leltdqtpvl lgstamatsl tnvgnsfsgp
       61 anplvsrsnk fqnssveddd dvvfiepvqp pppsvpvvad qrtitftssk neelqgndsk
      121 itpsskelas qkgsvsetiv iddeedmetn qgqeknssnf ierrppetkn rtndvdfsts
      181 sfsrsktktg vgpfnpgrmn vagdvfqnge sathhnpdsw isqsasfprn qkqpgvdsls
      241 pvaslpkqif qpsvqqqptk pvkvtcanck kplqkgqtay qrkgsahlfc sttclssfsh
      301 kpapkklcvm ckkdittmkg tivaqvdsse sfqefcstsc lslyedkqnp tkgalnksrc
      361 ticgklteir hevsfknmth klcsdhcfnr yrmanglimn cceqcgeylp skgagnnvlv
      421 idgqqkrfcc qscvseykqv gshpsflkev rdhmqdsflm qpekygkltt ctgcrtqcrf
      481 fdmtqcigpn gymepycsta cmnshktkya ksqslgiich fckrnslpqy qatmpdgkly
      541 nfcnsscvak fqalsmqssp ngqfvapsdi qlkcnyckns fcskpeilew enkvhqfcsk
      601 tcsddykklh civtyceycq eektlhetvn fsgvkrpfcs egckllykqd farrlglrcv
      661 tcnycsqlck kgatkeldgv vrdfcsedcc kkfqdwyyka arcdccksqg tlkervqwrg
      721 emkhfcdqhc llrfycqqne pnmttqkgpe nlhydqgcqt srtkmtgsap ppsptpnkem
      781 knkavlckpl tmtkatyckp hmqtkscqtd dtwrteyvpv pipvpvyipv pmhmysqnip
      841 vpttvpvpvp vpvflpapld ssekipaaie elkskvssda ldtelltmtd mmsedegkte
      901 ttninsviie tdiigsdllk nsdpetqssm pdvpyepdld ieidfpraae eldmenefll
      961 ppvfgeeyee qprprskkkg akrkavsgyq shddssdnse csfpfkytyg vnawkhwvkt
     1021 rqldedllvl delkssksvk lkedllshtt aelnyglahf vneirrpnge nyapdsiyyl
     1081 clgiqeylcg snrkdnifid pgyqtfeqel nkilrswqps ilpdgsifsr veedylwrik
     1141 qlgshspval lntlfyfntk yfglktveqh lrlsfgtvfr hwkknpltme nkaclryqvs
     1201 slcgtdnedk ittgkrkhed depvfeqien tanpsrcpvk mfecylsksp qnlnqrmdvf
     1261 ylqpecssst dspvwytsts ldrntlenml vrvllvkdiy dkdnyelded td
//
LOCUS       XP_047286550            1312 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger MYM-type protein 2 isoform X4 [Homo sapiens].
ACCESSION   XP_047286550
VERSION     XP_047286550.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430594.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 2% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1312
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1312
                     /product="zinc finger MYM-type protein 2 isoform X4"
                     /calculated_mol_wt=148102
     Region          262..298
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          303..344
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          355..391
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          397..437
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          466..505
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          569..606
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          657..693
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          699..734
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          1127..1295
                     /region_name="DUF3504"
                     /note="Domain of unknown function (DUF3504); pfam12012"
                     /db_xref="CDD:463430"
     CDS             1..1312
                     /gene="ZMYM2"
                     /gene_synonym="FIM; MYM; NECRC; RAMP; SCLL; ZNF198"
                     /coded_by="XM_047430594.1:309..4247"
                     /db_xref="GeneID:7750"
                     /db_xref="HGNC:HGNC:12989"
                     /db_xref="MIM:602221"
ORIGIN      
        1 mcillsavvt wipsldllvf fgmdtssvgg leltdqtpvl lgstamatsl tnvgnsfsgp
       61 anplvsrsnk fqnssveddd dvvfiepvqp pppsvpvvad qrtitftssk neelqgndsk
      121 itpsskelas qkgsvsetiv iddeedmetn qgqeknssnf ierrppetkn rtndvdfsts
      181 sfsrsktktg vgpfnpgrmn vagdvfqnge sathhnpdsw isqsasfprn qkqpgvdsls
      241 pvaslpkqif qpsvqqqptk pvkvtcanck kplqkgqtay qrkgsahlfc sttclssfsh
      301 kpapkklcvm ckkdittmkg tivaqvdsse sfqefcstsc lslyedkqnp tkgalnksrc
      361 ticgklteir hevsfknmth klcsdhcfnr yrmanglimn cceqcgeylp skgagnnvlv
      421 idgqqkrfcc qscvseykqv gshpsflkev rdhmqdsflm qpekygkltt ctgcrtqcrf
      481 fdmtqcigpn gymepycsta cmnshktkya ksqslgiich fckrnslpqy qatmpdgkly
      541 nfcnsscvak fqalsmqssp ngqfvapsdi qlkcnyckns fcskpeilew enkvhqfcsk
      601 tcsddykklh civtyceycq eektlhetvn fsgvkrpfcs egckllykqd farrlglrcv
      661 tcnycsqlck kgatkeldgv vrdfcsedcc kkfqdwyyka arcdccksqg tlkervqwrg
      721 emkhfcdqhc llrfycqqne pnmttqkgpe nlhydqgcqt srtkmtgsap ppsptpnkem
      781 knkavlckpl tmtkatyckp hmqtkscqtd dtwrteyvpv pipvpvyipv pmhmysqnip
      841 vpttvpvpvp vpvflpapld ssekipaaie elkskvssda ldtelltmtd mmsedegkte
      901 ttninsviie tdiigsdllk nsdpetqssm pdvpyepdld ieidfpraae eldmenefll
      961 ppvfgeeyee qprprskkkg akrkavsgyq shddssdnse csfpfkytyg vnawkhwvkt
     1021 rqldedllvl delkssksvk lkedllshtt aelnyglahf vneirrpnge nyapdsiyyl
     1081 clgiqeylcg snrkdnifid pgyqtfeqel nkilrswqps ilpdgsifsr veedylwrik
     1141 qlgshspval lntlfyfntk yfglktveqh lrlsfgtvfr hwkknpltme nkaclryqvs
     1201 slcgtdnedk ittgkrkhed depvfeqien tanpsrcpvk mfecylsksp qnlnqrmdvf
     1261 ylqpecssst dspvwytsts ldrntlenml vrvllvkdiy dkdnyelded td
//
LOCUS       XP_047286552            1290 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger MYM-type protein 2 isoform X5 [Homo sapiens].
ACCESSION   XP_047286552
VERSION     XP_047286552.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430596.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1290
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1290
                     /product="zinc finger MYM-type protein 2 isoform X5"
                     /calculated_mol_wt=145682
     Region          240..276
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          281..322
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          333..369
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          375..415
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          444..483
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          547..584
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          635..671
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          677..712
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          1105..1273
                     /region_name="DUF3504"
                     /note="Domain of unknown function (DUF3504); pfam12012"
                     /db_xref="CDD:463430"
     CDS             1..1290
                     /gene="ZMYM2"
                     /gene_synonym="FIM; MYM; NECRC; RAMP; SCLL; ZNF198"
                     /coded_by="XM_047430596.1:227..4099"
                     /db_xref="GeneID:7750"
                     /db_xref="HGNC:HGNC:12989"
                     /db_xref="MIM:602221"
ORIGIN      
        1 mdtssvggle ltdqtpvllg stamatsltn vgnsfsgpan plvsrsnkfq nssveddddv
       61 vfiepvqppp psvpvvadqr titftsskne elqgndskit psskelasqk gsvsetivid
      121 deedmetnqg qeknssnfie rrppetknrt ndvdfstssf srsktktgvg pfnpgrmnva
      181 gdvfqngesa thhnpdswis qsasfprnqk qpgvdslspv aslpkqifqp svqqqptkpv
      241 kvtcanckkp lqkgqtayqr kgsahlfcst tclssfshkp apkklcvmck kdittmkgti
      301 vaqvdssesf qefcstscls lyedkqnptk galnksrcti cgklteirhe vsfknmthkl
      361 csdhcfnryr manglimncc eqcgeylpsk gagnnvlvid gqqkrfccqs cvseykqvgs
      421 hpsflkevrd hmqdsflmqp ekygklttct gcrtqcrffd mtqcigpngy mepycstacm
      481 nshktkyaks qslgiichfc krnslpqyqa tmpdgklynf cnsscvakfq alsmqsspng
      541 qfvapsdiql kcnycknsfc skpeilewen kvhqfcsktc sddykklhci vtyceycqee
      601 ktlhetvnfs gvkrpfcseg ckllykqdfa rrlglrcvtc nycsqlckkg atkeldgvvr
      661 dfcsedcckk fqdwyykaar cdccksqgtl kervqwrgem khfcdqhcll rfycqqnepn
      721 mttqkgpenl hydqgcqtsr tkmtgsappp sptpnkemkn kavlckpltm tkatyckphm
      781 qtkscqtddt wrteyvpvpi pvpvyipvpm hmysqnipvp ttvpvpvpvp vflpapldss
      841 ekipaaieel kskvssdald telltmtdmm sedegktett ninsviietd iigsdllkns
      901 dpetqssmpd vpyepdldie idfpraaeel dmenefllpp vfgeeyeeqp rprskkkgak
      961 rkavsgyqsh ddssdnsecs fpfkytygvn awkhwvktrq ldedllvlde lkssksvklk
     1021 edllshttae lnyglahfvn eirrpngeny apdsiyylcl giqeylcgsn rkdnifidpg
     1081 yqtfeqelnk ilrswqpsil pdgsifsrve edylwrikql gshspvalln tlfyfntkyf
     1141 glktveqhlr lsfgtvfrhw kknpltmenk aclryqvssl cgtdnedkit tgkrkhedde
     1201 pvfeqienta npsrcpvkmf ecylskspqn lnqrmdvfyl qpecssstds pvwytstsld
     1261 rntlenmlvr vllvkdiydk dnyeldedtd
//
LOCUS       XP_047286553            1290 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger MYM-type protein 2 isoform X5 [Homo sapiens].
ACCESSION   XP_047286553
VERSION     XP_047286553.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430597.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1290
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1290
                     /product="zinc finger MYM-type protein 2 isoform X5"
                     /calculated_mol_wt=145682
     Region          240..276
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          281..322
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          333..369
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          375..415
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          444..483
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          547..584
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          635..671
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          677..712
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          1105..1273
                     /region_name="DUF3504"
                     /note="Domain of unknown function (DUF3504); pfam12012"
                     /db_xref="CDD:463430"
     CDS             1..1290
                     /gene="ZMYM2"
                     /gene_synonym="FIM; MYM; NECRC; RAMP; SCLL; ZNF198"
                     /coded_by="XM_047430597.1:169..4041"
                     /db_xref="GeneID:7750"
                     /db_xref="HGNC:HGNC:12989"
                     /db_xref="MIM:602221"
ORIGIN      
        1 mdtssvggle ltdqtpvllg stamatsltn vgnsfsgpan plvsrsnkfq nssveddddv
       61 vfiepvqppp psvpvvadqr titftsskne elqgndskit psskelasqk gsvsetivid
      121 deedmetnqg qeknssnfie rrppetknrt ndvdfstssf srsktktgvg pfnpgrmnva
      181 gdvfqngesa thhnpdswis qsasfprnqk qpgvdslspv aslpkqifqp svqqqptkpv
      241 kvtcanckkp lqkgqtayqr kgsahlfcst tclssfshkp apkklcvmck kdittmkgti
      301 vaqvdssesf qefcstscls lyedkqnptk galnksrcti cgklteirhe vsfknmthkl
      361 csdhcfnryr manglimncc eqcgeylpsk gagnnvlvid gqqkrfccqs cvseykqvgs
      421 hpsflkevrd hmqdsflmqp ekygklttct gcrtqcrffd mtqcigpngy mepycstacm
      481 nshktkyaks qslgiichfc krnslpqyqa tmpdgklynf cnsscvakfq alsmqsspng
      541 qfvapsdiql kcnycknsfc skpeilewen kvhqfcsktc sddykklhci vtyceycqee
      601 ktlhetvnfs gvkrpfcseg ckllykqdfa rrlglrcvtc nycsqlckkg atkeldgvvr
      661 dfcsedcckk fqdwyykaar cdccksqgtl kervqwrgem khfcdqhcll rfycqqnepn
      721 mttqkgpenl hydqgcqtsr tkmtgsappp sptpnkemkn kavlckpltm tkatyckphm
      781 qtkscqtddt wrteyvpvpi pvpvyipvpm hmysqnipvp ttvpvpvpvp vflpapldss
      841 ekipaaieel kskvssdald telltmtdmm sedegktett ninsviietd iigsdllkns
      901 dpetqssmpd vpyepdldie idfpraaeel dmenefllpp vfgeeyeeqp rprskkkgak
      961 rkavsgyqsh ddssdnsecs fpfkytygvn awkhwvktrq ldedllvlde lkssksvklk
     1021 edllshttae lnyglahfvn eirrpngeny apdsiyylcl giqeylcgsn rkdnifidpg
     1081 yqtfeqelnk ilrswqpsil pdgsifsrve edylwrikql gshspvalln tlfyfntkyf
     1141 glktveqhlr lsfgtvfrhw kknpltmenk aclryqvssl cgtdnedkit tgkrkhedde
     1201 pvfeqienta npsrcpvkmf ecylskspqn lnqrmdvfyl qpecssstds pvwytstsld
     1261 rntlenmlvr vllvkdiydk dnyeldedtd
//
LOCUS       XP_047286554            1290 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger MYM-type protein 2 isoform X5 [Homo sapiens].
ACCESSION   XP_047286554
VERSION     XP_047286554.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430598.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1290
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1290
                     /product="zinc finger MYM-type protein 2 isoform X5"
                     /calculated_mol_wt=145682
     Region          240..276
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          281..322
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          333..369
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          375..415
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          444..483
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          547..584
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          635..671
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          677..712
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          1105..1273
                     /region_name="DUF3504"
                     /note="Domain of unknown function (DUF3504); pfam12012"
                     /db_xref="CDD:463430"
     CDS             1..1290
                     /gene="ZMYM2"
                     /gene_synonym="FIM; MYM; NECRC; RAMP; SCLL; ZNF198"
                     /coded_by="XM_047430598.1:144..4016"
                     /db_xref="GeneID:7750"
                     /db_xref="HGNC:HGNC:12989"
                     /db_xref="MIM:602221"
ORIGIN      
        1 mdtssvggle ltdqtpvllg stamatsltn vgnsfsgpan plvsrsnkfq nssveddddv
       61 vfiepvqppp psvpvvadqr titftsskne elqgndskit psskelasqk gsvsetivid
      121 deedmetnqg qeknssnfie rrppetknrt ndvdfstssf srsktktgvg pfnpgrmnva
      181 gdvfqngesa thhnpdswis qsasfprnqk qpgvdslspv aslpkqifqp svqqqptkpv
      241 kvtcanckkp lqkgqtayqr kgsahlfcst tclssfshkp apkklcvmck kdittmkgti
      301 vaqvdssesf qefcstscls lyedkqnptk galnksrcti cgklteirhe vsfknmthkl
      361 csdhcfnryr manglimncc eqcgeylpsk gagnnvlvid gqqkrfccqs cvseykqvgs
      421 hpsflkevrd hmqdsflmqp ekygklttct gcrtqcrffd mtqcigpngy mepycstacm
      481 nshktkyaks qslgiichfc krnslpqyqa tmpdgklynf cnsscvakfq alsmqsspng
      541 qfvapsdiql kcnycknsfc skpeilewen kvhqfcsktc sddykklhci vtyceycqee
      601 ktlhetvnfs gvkrpfcseg ckllykqdfa rrlglrcvtc nycsqlckkg atkeldgvvr
      661 dfcsedcckk fqdwyykaar cdccksqgtl kervqwrgem khfcdqhcll rfycqqnepn
      721 mttqkgpenl hydqgcqtsr tkmtgsappp sptpnkemkn kavlckpltm tkatyckphm
      781 qtkscqtddt wrteyvpvpi pvpvyipvpm hmysqnipvp ttvpvpvpvp vflpapldss
      841 ekipaaieel kskvssdald telltmtdmm sedegktett ninsviietd iigsdllkns
      901 dpetqssmpd vpyepdldie idfpraaeel dmenefllpp vfgeeyeeqp rprskkkgak
      961 rkavsgyqsh ddssdnsecs fpfkytygvn awkhwvktrq ldedllvlde lkssksvklk
     1021 edllshttae lnyglahfvn eirrpngeny apdsiyylcl giqeylcgsn rkdnifidpg
     1081 yqtfeqelnk ilrswqpsil pdgsifsrve edylwrikql gshspvalln tlfyfntkyf
     1141 glktveqhlr lsfgtvfrhw kknpltmenk aclryqvssl cgtdnedkit tgkrkhedde
     1201 pvfeqienta npsrcpvkmf ecylskspqn lnqrmdvfyl qpecssstds pvwytstsld
     1261 rntlenmlvr vllvkdiydk dnyeldedtd
//
LOCUS       XP_047286555            1223 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger MYM-type protein 2 isoform X6 [Homo sapiens].
ACCESSION   XP_047286555
VERSION     XP_047286555.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430599.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1223
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1223
                     /product="zinc finger MYM-type protein 2 isoform X6"
                     /calculated_mol_wt=136534
     Region          349..385
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          390..431
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          442..478
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          484..524
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          553..592
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          656..693
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          744..780
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          786..821
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     CDS             1..1223
                     /gene="ZMYM2"
                     /gene_synonym="FIM; MYM; NECRC; RAMP; SCLL; ZNF198"
                     /coded_by="XM_047430599.1:121..3792"
                     /db_xref="GeneID:7750"
                     /db_xref="HGNC:HGNC:12989"
                     /db_xref="MIM:602221"
ORIGIN      
        1 mcillsavvt wipsldllvf fgmdtssvgg leltdqtpvl lgstamatsl tnvgnsfsgp
       61 anplvsrsnk fqnssveddd dvvfiepvqp pppsvpvvad qrtitftssk neelqgndsk
      121 itpsskelas qkgsvsetiv iddeedmetn qgqeknssnf ierrppetkn rtndvdfsts
      181 sfsrskvnag mgnsgittep dseiqianvt tletgvssvn dgqlentdgr dmnlmithvt
      241 slqntnlgdv snglqssnfg vniqtytpsl tsqtktgvgp fnpgrmnvag dvfqngesat
      301 hhnpdswisq sasfprnqkq pgvdslspva slpkqifqps vqqqptkpvk vtcanckkpl
      361 qkgqtayqrk gsahlfcstt clssfshkpa pkklcvmckk dittmkgtiv aqvdssesfq
      421 efcstsclsl yedkqnptkg alnksrctic gklteirhev sfknmthklc sdhcfnryrm
      481 anglimncce qcgeylpskg agnnvlvidg qqkrfccqsc vseykqvgsh psflkevrdh
      541 mqdsflmqpe kygklttctg crtqcrffdm tqcigpngym epycstacmn shktkyaksq
      601 slgiichfck rnslpqyqat mpdgklynfc nsscvakfqa lsmqsspngq fvapsdiqlk
      661 cnycknsfcs kpeilewenk vhqfcsktcs ddykklhciv tyceycqeek tlhetvnfsg
      721 vkrpfcsegc kllykqdfar rlglrcvtcn ycsqlckkga tkeldgvvrd fcsedcckkf
      781 qdwyykaarc dccksqgtlk ervqwrgemk hfcdqhcllr fycqqnepnm ttqkgpenlh
      841 ydqgcqtsrt kmtgsappps ptpnkemknk avlckpltmt katyckphmq tkscqtddtw
      901 rteyvpvpip vpvyipvpmh mysqnipvpt tvpvpvpvpv flpapldsse kipaaieelk
      961 skvssdaldt elltmtdmms edegktettn insviietdi igsdllknsd petqssmpdv
     1021 pyepdldiei dfpraaeeld menefllppv fgeeyeeqpr prskkkgakr kavsgyqshd
     1081 dssdnsecsf pfkytygvna wkhwvktrql dedllvldel kssksvklke dllshttael
     1141 nyglahfvne irrpngenya pdsiyylclg iqedrnllki lphlsasvqt vmlpwiqcrv
     1201 altlmfvqgf lhqwpalsif vwk
//
LOCUS       XP_024305175            1181 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger MYM-type protein 2 isoform X7 [Homo sapiens].
ACCESSION   XP_024305175
VERSION     XP_024305175.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449407.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1181
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1181
                     /product="zinc finger MYM-type protein 2 isoform X7"
                     /calculated_mol_wt=131671
     Region          349..385
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          390..431
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          442..478
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          484..524
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          553..592
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          656..693
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          744..780
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          786..821
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     CDS             1..1181
                     /gene="ZMYM2"
                     /gene_synonym="FIM; MYM; NECRC; RAMP; SCLL; ZNF198"
                     /coded_by="XM_024449407.2:121..3666"
                     /db_xref="GeneID:7750"
                     /db_xref="HGNC:HGNC:12989"
                     /db_xref="MIM:602221"
ORIGIN      
        1 mcillsavvt wipsldllvf fgmdtssvgg leltdqtpvl lgstamatsl tnvgnsfsgp
       61 anplvsrsnk fqnssveddd dvvfiepvqp pppsvpvvad qrtitftssk neelqgndsk
      121 itpsskelas qkgsvsetiv iddeedmetn qgqeknssnf ierrppetkn rtndvdfsts
      181 sfsrskvnag mgnsgittep dseiqianvt tletgvssvn dgqlentdgr dmnlmithvt
      241 slqntnlgdv snglqssnfg vniqtytpsl tsqtktgvgp fnpgrmnvag dvfqngesat
      301 hhnpdswisq sasfprnqkq pgvdslspva slpkqifqps vqqqptkpvk vtcanckkpl
      361 qkgqtayqrk gsahlfcstt clssfshkpa pkklcvmckk dittmkgtiv aqvdssesfq
      421 efcstsclsl yedkqnptkg alnksrctic gklteirhev sfknmthklc sdhcfnryrm
      481 anglimncce qcgeylpskg agnnvlvidg qqkrfccqsc vseykqvgsh psflkevrdh
      541 mqdsflmqpe kygklttctg crtqcrffdm tqcigpngym epycstacmn shktkyaksq
      601 slgiichfck rnslpqyqat mpdgklynfc nsscvakfqa lsmqsspngq fvapsdiqlk
      661 cnycknsfcs kpeilewenk vhqfcsktcs ddykklhciv tyceycqeek tlhetvnfsg
      721 vkrpfcsegc kllykqdfar rlglrcvtcn ycsqlckkga tkeldgvvrd fcsedcckkf
      781 qdwyykaarc dccksqgtlk ervqwrgemk hfcdqhcllr fycqqnepnm ttqkgpenlh
      841 ydqgcqtsrt kmtgsappps ptpnkemknk avlckpltmt katyckphmq tkscqtddtw
      901 rteyvpvpip vpvyipvpmh mysqnipvpt tvpvpvpvpv flpapldsse kipaaieelk
      961 skvssdaldt elltmtdmms edegktettn insviietdi igsdllknsd petqssmpdv
     1021 pyepdldiei dfpraaeeld menefllppv fgeeyeeqpr prskkkgakr kavsgyqshd
     1081 dssdnsecsf pfkytygvna wkhwvktrql dedllvldel kssksvklke dllshttael
     1141 nyglahfvne irrpngenya pdsiyylclg iqedrnllki l
//
LOCUS       XP_047286556            1159 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger MYM-type protein 2 isoform X8 [Homo sapiens].
ACCESSION   XP_047286556
VERSION     XP_047286556.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430600.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1159
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1159
                     /product="zinc finger MYM-type protein 2 isoform X8"
                     /calculated_mol_wt=129251
     Region          327..363
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          368..409
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          420..456
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          462..502
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          531..570
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          634..671
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          722..758
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          764..799
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     CDS             1..1159
                     /gene="ZMYM2"
                     /gene_synonym="FIM; MYM; NECRC; RAMP; SCLL; ZNF198"
                     /coded_by="XM_047430600.1:192..3671"
                     /db_xref="GeneID:7750"
                     /db_xref="HGNC:HGNC:12989"
                     /db_xref="MIM:602221"
ORIGIN      
        1 mdtssvggle ltdqtpvllg stamatsltn vgnsfsgpan plvsrsnkfq nssveddddv
       61 vfiepvqppp psvpvvadqr titftsskne elqgndskit psskelasqk gsvsetivid
      121 deedmetnqg qeknssnfie rrppetknrt ndvdfstssf srskvnagmg nsgittepds
      181 eiqianvttl etgvssvndg qlentdgrdm nlmithvtsl qntnlgdvsn glqssnfgvn
      241 iqtytpslts qtktgvgpfn pgrmnvagdv fqngesathh npdswisqsa sfprnqkqpg
      301 vdslspvasl pkqifqpsvq qqptkpvkvt canckkplqk gqtayqrkgs ahlfcsttcl
      361 ssfshkpapk klcvmckkdi ttmkgtivaq vdssesfqef cstsclslye dkqnptkgal
      421 nksrcticgk lteirhevsf knmthklcsd hcfnryrman glimncceqc geylpskgag
      481 nnvlvidgqq krfccqscvs eykqvgshps flkevrdhmq dsflmqpeky gklttctgcr
      541 tqcrffdmtq cigpngymep ycstacmnsh ktkyaksqsl giichfckrn slpqyqatmp
      601 dgklynfcns scvakfqals mqsspngqfv apsdiqlkcn ycknsfcskp eilewenkvh
      661 qfcsktcsdd ykklhcivty ceycqeektl hetvnfsgvk rpfcsegckl lykqdfarrl
      721 glrcvtcnyc sqlckkgatk eldgvvrdfc sedcckkfqd wyykaarcdc cksqgtlker
      781 vqwrgemkhf cdqhcllrfy cqqnepnmtt qkgpenlhyd qgcqtsrtkm tgsapppspt
      841 pnkemknkav lckpltmtka tyckphmqtk scqtddtwrt eyvpvpipvp vyipvpmhmy
      901 sqnipvpttv pvpvpvpvfl papldsseki paaieelksk vssdaldtel ltmtdmmsed
      961 egktettnin sviietdiig sdllknsdpe tqssmpdvpy epdldieidf praaeeldme
     1021 nefllppvfg eeyeeqprpr skkkgakrka vsgyqshdds sdnsecsfpf kytygvnawk
     1081 hwvktrqlde dllvldelks sksvklkedl lshttaelny glahfvneir rpngenyapd
     1141 siyylclgiq edrnllkil
//
LOCUS       XP_047286557            1072 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger MYM-type protein 2 isoform X9 [Homo sapiens].
ACCESSION   XP_047286557
VERSION     XP_047286557.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430601.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1072
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1072
                     /product="zinc finger MYM-type protein 2 isoform X9"
                     /calculated_mol_wt=120152
     Region          240..276
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          281..322
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          333..369
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          375..415
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          444..483
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          547..584
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          635..671
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          677..712
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     CDS             1..1072
                     /gene="ZMYM2"
                     /gene_synonym="FIM; MYM; NECRC; RAMP; SCLL; ZNF198"
                     /coded_by="XM_047430601.1:192..3410"
                     /db_xref="GeneID:7750"
                     /db_xref="HGNC:HGNC:12989"
                     /db_xref="MIM:602221"
ORIGIN      
        1 mdtssvggle ltdqtpvllg stamatsltn vgnsfsgpan plvsrsnkfq nssveddddv
       61 vfiepvqppp psvpvvadqr titftsskne elqgndskit psskelasqk gsvsetivid
      121 deedmetnqg qeknssnfie rrppetknrt ndvdfstssf srsktktgvg pfnpgrmnva
      181 gdvfqngesa thhnpdswis qsasfprnqk qpgvdslspv aslpkqifqp svqqqptkpv
      241 kvtcanckkp lqkgqtayqr kgsahlfcst tclssfshkp apkklcvmck kdittmkgti
      301 vaqvdssesf qefcstscls lyedkqnptk galnksrcti cgklteirhe vsfknmthkl
      361 csdhcfnryr manglimncc eqcgeylpsk gagnnvlvid gqqkrfccqs cvseykqvgs
      421 hpsflkevrd hmqdsflmqp ekygklttct gcrtqcrffd mtqcigpngy mepycstacm
      481 nshktkyaks qslgiichfc krnslpqyqa tmpdgklynf cnsscvakfq alsmqsspng
      541 qfvapsdiql kcnycknsfc skpeilewen kvhqfcsktc sddykklhci vtyceycqee
      601 ktlhetvnfs gvkrpfcseg ckllykqdfa rrlglrcvtc nycsqlckkg atkeldgvvr
      661 dfcsedcckk fqdwyykaar cdccksqgtl kervqwrgem khfcdqhcll rfycqqnepn
      721 mttqkgpenl hydqgcqtsr tkmtgsappp sptpnkemkn kavlckpltm tkatyckphm
      781 qtkscqtddt wrteyvpvpi pvpvyipvpm hmysqnipvp ttvpvpvpvp vflpapldss
      841 ekipaaieel kskvssdald telltmtdmm sedegktett ninsviietd iigsdllkns
      901 dpetqssmpd vpyepdldie idfpraaeel dmenefllpp vfgeeyeeqp rprskkkgak
      961 rkavsgyqsh ddssdnsecs fpfkytygvn awkhwvktrq ldedllvlde lkssksvklk
     1021 edllshttae lnyglahfvn eirrpngeny apdsiyylcl giqedrnllk il
//
LOCUS       XP_011533525             866 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger MYM-type protein 2 isoform X10 [Homo sapiens].
ACCESSION   XP_011533525
VERSION     XP_011533525.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535223.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..866
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..866
                     /product="zinc finger MYM-type protein 2 isoform X10"
                     /calculated_mol_wt=99367
     Region          20..59
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          123..160
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          211..247
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          253..288
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          681..849
                     /region_name="DUF3504"
                     /note="Domain of unknown function (DUF3504); pfam12012"
                     /db_xref="CDD:463430"
     CDS             1..866
                     /gene="ZMYM2"
                     /gene_synonym="FIM; MYM; NECRC; RAMP; SCLL; ZNF198"
                     /coded_by="XM_011535223.3:2626..5226"
                     /db_xref="GeneID:7750"
                     /db_xref="HGNC:HGNC:12989"
                     /db_xref="MIM:602221"
ORIGIN      
        1 mtefcnhsed qnnlhlkkyg klttctgcrt qcrffdmtqc igpngymepy cstacmnshk
       61 tkyaksqslg iichfckrns lpqyqatmpd gklynfcnss cvakfqalsm qsspngqfva
      121 psdiqlkcny cknsfcskpe ilewenkvhq fcsktcsddy kklhcivtyc eycqeektlh
      181 etvnfsgvkr pfcsegckll ykqdfarrlg lrcvtcnycs qlckkgatke ldgvvrdfcs
      241 edcckkfqdw yykaarcdcc ksqgtlkerv qwrgemkhfc dqhcllrfyc qqnepnmttq
      301 kgpenlhydq gcqtsrtkmt gsapppsptp nkemknkavl ckpltmtkat yckphmqtks
      361 cqtddtwrte yvpvpipvpv yipvpmhmys qnipvpttvp vpvpvpvflp apldssekip
      421 aaieelkskv ssdaldtell tmtdmmsede gktettnins viietdiigs dllknsdpet
      481 qssmpdvpye pdldieidfp raaeeldmen efllppvfge eyeeqprprs kkkgakrkav
      541 sgyqshddss dnsecsfpfk ytygvnawkh wvktrqlded llvldelkss ksvklkedll
      601 shttaelnyg lahfvneirr pngenyapds iyylclgiqe ylcgsnrkdn ifidpgyqtf
      661 eqelnkilrs wqpsilpdgs ifsrveedyl wrikqlgshs pvallntlfy fntkyfglkt
      721 veqhlrlsfg tvfrhwkknp ltmenkaclr yqvsslcgtd nedkittgkr kheddepvfe
      781 qientanpsr cpvkmfecyl skspqnlnqr mdvfylqpec ssstdspvwy tstsldrntl
      841 enmlvrvllv kdiydkdnye ldedtd
//
LOCUS       XP_047286558             468 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger MYM-type protein 2 isoform X11 [Homo sapiens].
ACCESSION   XP_047286558
VERSION     XP_047286558.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430602.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..468
                     /product="zinc finger MYM-type protein 2 isoform X11"
                     /calculated_mol_wt=51176
     Region          262..298
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          303..344
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          355..391
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          397..437
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     CDS             1..468
                     /gene="ZMYM2"
                     /gene_synonym="FIM; MYM; NECRC; RAMP; SCLL; ZNF198"
                     /coded_by="XM_047430602.1:121..1527"
                     /db_xref="GeneID:7750"
                     /db_xref="HGNC:HGNC:12989"
                     /db_xref="MIM:602221"
ORIGIN      
        1 mcillsavvt wipsldllvf fgmdtssvgg leltdqtpvl lgstamatsl tnvgnsfsgp
       61 anplvsrsnk fqnssveddd dvvfiepvqp pppsvpvvad qrtitftssk neelqgndsk
      121 itpsskelas qkgsvsetiv iddeedmetn qgqeknssnf ierrppetkn rtndvdfsts
      181 sfsrsktktg vgpfnpgrmn vagdvfqnge sathhnpdsw isqsasfprn qkqpgvdsls
      241 pvaslpkqif qpsvqqqptk pvkvtcanck kplqkgqtay qrkgsahlfc sttclssfsh
      301 kpapkklcvm ckkdittmkg tivaqvdsse sfqefcstsc lslyedkqnp tkgalnksrc
      361 ticgklteir hevsfknmth klcsdhcfnr yrmanglimn cceqcgeylp skgagnnvlv
      421 idgqqkrfcc qscvseykqv gshpsflkev rdhmqdsflm qpetnlai
//
LOCUS       XP_047286559             446 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger MYM-type protein 2 isoform X12 [Homo sapiens].
ACCESSION   XP_047286559
VERSION     XP_047286559.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430603.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..446
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..446
                     /product="zinc finger MYM-type protein 2 isoform X12"
                     /calculated_mol_wt=48756
     Region          240..276
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          281..322
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          333..369
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          375..415
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     CDS             1..446
                     /gene="ZMYM2"
                     /gene_synonym="FIM; MYM; NECRC; RAMP; SCLL; ZNF198"
                     /coded_by="XM_047430603.1:192..1532"
                     /db_xref="GeneID:7750"
                     /db_xref="HGNC:HGNC:12989"
                     /db_xref="MIM:602221"
ORIGIN      
        1 mdtssvggle ltdqtpvllg stamatsltn vgnsfsgpan plvsrsnkfq nssveddddv
       61 vfiepvqppp psvpvvadqr titftsskne elqgndskit psskelasqk gsvsetivid
      121 deedmetnqg qeknssnfie rrppetknrt ndvdfstssf srsktktgvg pfnpgrmnva
      181 gdvfqngesa thhnpdswis qsasfprnqk qpgvdslspv aslpkqifqp svqqqptkpv
      241 kvtcanckkp lqkgqtayqr kgsahlfcst tclssfshkp apkklcvmck kdittmkgti
      301 vaqvdssesf qefcstscls lyedkqnptk galnksrcti cgklteirhe vsfknmthkl
      361 csdhcfnryr manglimncc eqcgeylpsk gagnnvlvid gqqkrfccqs cvseykqvgs
      421 hpsflkevrd hmqdsflmqp etnlai
//
LOCUS       XP_016876229             102 aa            linear   PRI 05-AUG-2025
DEFINITION  large ribosomal subunit protein mL63 isoform X1 [Homo sapiens].
ACCESSION   XP_016876229
VERSION     XP_016876229.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020740.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..102
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..102
                     /product="large ribosomal subunit protein mL63 isoform X1"
                     /calculated_mol_wt=12135
     Region          13..101
                     /region_name="MRP-63"
                     /note="Mitochondrial ribosome protein 63; pfam14978"
                     /db_xref="CDD:434363"
     CDS             1..102
                     /gene="MRPL57"
                     /gene_synonym="bMRP63; mL63; MRP63"
                     /coded_by="XM_017020740.3:116..424"
                     /db_xref="GeneID:78988"
                     /db_xref="HGNC:HGNC:14514"
                     /db_xref="MIM:611997"
ORIGIN      
        1 mfltallwrg ripgrqwigk hrrprfvslr akqnmirrle ieaenhywls mpymtreqer
       61 ghaavrrrea feaikaaats kfpphrfiad qldhlnvtkk ws
//
LOCUS       XP_047286560             283 aa            linear   PRI 05-AUG-2025
DEFINITION  protein O-glucosyltransferase 2 isoform X2 [Homo sapiens].
ACCESSION   XP_047286560
VERSION     XP_047286560.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430604.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..283
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..283
                     /product="protein O-glucosyltransferase 2 isoform X2"
                     /calculated_mol_wt=33091
     Region          2..265
                     /region_name="Glyco_transf_90"
                     /note="Glycosyl transferase family 90; cl23835"
                     /db_xref="CDD:329112"
     CDS             1..283
                     /gene="POGLUT2"
                     /gene_synonym="EP58; ERp58; KDEL1; KDELC1"
                     /coded_by="XM_047430604.1:209..1060"
                     /db_xref="GeneID:79070"
                     /db_xref="HGNC:HGNC:19350"
                     /db_xref="MIM:611613"
ORIGIN      
        1 mllrlvkmpd velfvnlgdw plekkksnsn ihpifswcgs tdskdivmpt ydltdsvlet
       61 mgrvsldmms vqantgppwe sknstavwrg rdsrkerlel vklsrkhpel idaaftnfff
      121 fkhdenlygp ivkhisffdf fkhkyqinid gtvaayrlpy llvgdsvvlk qdsiyyehfy
      181 nelqpwkhyi pvksnlsdll eklkwakdhd eeakkiakag qefarnnlmg ddifcyyfkl
      241 fqeyanlqvs epqiregmkr vepqteddlf pctchrkktk del
//
LOCUS       XP_047286561             487 aa            linear   PRI 05-AUG-2025
DEFINITION  putative cysteine--tRNA ligase, mitochondrial isoform X1 [Homo
            sapiens].
ACCESSION   XP_047286561
VERSION     XP_047286561.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430605.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..487
                     /product="putative cysteine--tRNA ligase, mitochondrial
                     isoform X1"
                     /calculated_mol_wt=53588
     Region          35..>360
                     /region_name="PTZ00399"
                     /note="cysteinyl-tRNA-synthetase; Provisional"
                     /db_xref="CDD:240402"
     CDS             1..487
                     /gene="CARS2"
                     /gene_synonym="COXPD27; cysRS"
                     /coded_by="XM_047430605.1:24..1487"
                     /db_xref="GeneID:79587"
                     /db_xref="HGNC:HGNC:25695"
                     /db_xref="MIM:612800"
ORIGIN      
        1 mlrttrgpgl gppllqaalg lgragwhwpa graasggrgr awlqptgret gvqvynsltg
       61 rkeplivaha eaaswyscgp tvydhahlgh acsyvrfdii rriltkvfgc sivmvmgitd
      121 vddkiikran emnispasla slyeedfkqd maalkvlppt vylrvtenip qiisfiegii
      181 argnaystak gnvyfdlksr gdkygklvgv vpgpvgepad sdkrhasdfa lwkaakpqev
      241 fwaspwgpgr pgwhiecsai asmvfgsqld ihsggidlaf phheneiaqc evfhqceqwg
      301 nyflhsghlh akgkeekmsk slknyitikd flktfspdvf rffclrssyr saidysdsam
      361 lqaqqlllgl gsfledaray mkgqlacgsv reamlwerpg ptaspplpth gcpgqrctfi
      421 pacrvfrmvl vithpchfsr vgsqwpreae irepragppq plfvsgqpcr lsptesslpl
      481 psisidf
//
LOCUS       XP_006720016             451 aa            linear   PRI 05-AUG-2025
DEFINITION  putative cysteine--tRNA ligase, mitochondrial isoform X2 [Homo
            sapiens].
ACCESSION   XP_006720016
VERSION     XP_006720016.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006719953.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..451
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..451
                     /product="putative cysteine--tRNA ligase, mitochondrial
                     isoform X2"
                     /calculated_mol_wt=49933
     Region          1..450
                     /region_name="PTZ00399"
                     /note="cysteinyl-tRNA-synthetase; Provisional"
                     /db_xref="CDD:240402"
     CDS             1..451
                     /gene="CARS2"
                     /gene_synonym="COXPD27; cysRS"
                     /coded_by="XM_006719953.4:502..1857"
                     /db_xref="GeneID:79587"
                     /db_xref="HGNC:HGNC:25695"
                     /db_xref="MIM:612800"
ORIGIN      
        1 mvmgitdvdd kiikranemn ispaslasly eedfkqdmaa lkvlpptvyl rvtenipqii
       61 sfiegiiarg naystakgnv yfdlksrgdk ygklvgvvpg pvgepadsdk rhasdfalwk
      121 aakpqevfwa spwgpgrpgw hiecsaiasm vfgsqldihs ggidlafphh eneiaqcevf
      181 hqceqwgnyf lhsghlhakg keekmskslk nyitikdflk tfspdvfrff clrssyrsai
      241 dysdsamlqa qqlllglgsf ledaraymkg qlacgsvrea mlwerlsstk ravkaaladd
      301 fdtprvvdai lglahhgngq lraslkepeg prspavfgai isyfeqffet vgislanqqy
      361 vsgdgseatl hgvvdelvrf rqkvrqfala mpeatgdarr qqllerqpll eacdtlrrgl
      421 tahginikdr ssttstwell dqrtkdqksa g
//
LOCUS       XP_047286562             449 aa            linear   PRI 05-AUG-2025
DEFINITION  putative cysteine--tRNA ligase, mitochondrial isoform X3 [Homo
            sapiens].
ACCESSION   XP_047286562
VERSION     XP_047286562.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430606.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..449
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..449
                     /product="putative cysteine--tRNA ligase, mitochondrial
                     isoform X3"
                     /calculated_mol_wt=49793
     Region          9..448
                     /region_name="PTZ00399"
                     /note="cysteinyl-tRNA-synthetase; Provisional"
                     /db_xref="CDD:240402"
     CDS             1..449
                     /gene="CARS2"
                     /gene_synonym="COXPD27; cysRS"
                     /coded_by="XM_047430606.1:92..1441"
                     /db_xref="GeneID:79587"
                     /db_xref="HGNC:HGNC:25695"
                     /db_xref="MIM:612800"
ORIGIN      
        1 msqrngvrsl rniftemnis paslaslyee dfkqdmaalk vlpptvylrv tenipqiisf
       61 iegiiargna ystakgnvyf dlksrgdkyg klvgvvpgpv gepadsdkrh asdfalwkaa
      121 kpqevfwasp wgpgrpgwhi ecsaiasmvf gsqldihsgg idlafphhen eiaqcevfhq
      181 ceqwgnyflh sghlhakgke ekmskslkny itikdflktf spdvfrffcl rssyrsaidy
      241 sdsamlqaqq lllglgsfle daraymkgql acgsvreaml werlsstkra vkaaladdfd
      301 tprvvdailg lahhgngqlr aslkepegpr spavfgaiis yfeqffetvg islanqqyvs
      361 gdgseatlhg vvdelvrfrq kvrqfalamp eatgdarrqq llerqpllea cdtlrrglta
      421 hginikdrss ttstwelldq rtkdqksag
//
LOCUS       XP_047286563             446 aa            linear   PRI 05-AUG-2025
DEFINITION  putative cysteine--tRNA ligase, mitochondrial isoform X4 [Homo
            sapiens].
ACCESSION   XP_047286563
VERSION     XP_047286563.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430607.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..446
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..446
                     /product="putative cysteine--tRNA ligase, mitochondrial
                     isoform X4"
                     /calculated_mol_wt=48982
     Region          35..>446
                     /region_name="PTZ00399"
                     /note="cysteinyl-tRNA-synthetase; Provisional"
                     /db_xref="CDD:240402"
     CDS             1..446
                     /gene="CARS2"
                     /gene_synonym="COXPD27; cysRS"
                     /coded_by="XM_047430607.1:24..1364"
                     /db_xref="GeneID:79587"
                     /db_xref="HGNC:HGNC:25695"
                     /db_xref="MIM:612800"
ORIGIN      
        1 mlrttrgpgl gppllqaalg lgragwhwpa graasggrgr awlqptgret gvqvynsltg
       61 rkeplivaha eaaswyscgp tvydhahlgh acsyvrfdii rriltkvfgc sivmvmgitd
      121 vddkiikran emnispasla slyeedfkqd maalkvlppt vylrvtenip qiisfiegii
      181 argnaystak gnvyfdlksr gdkygklvgv vpgpvgepad sdkrhasdfa lwkaakpqev
      241 fwaspwgpgr pgwhiecsai asmvfgsqld ihsggidlaf phheneiaqc evfhqceqwg
      301 nyflhsghlh akgkeekmsk slknyitikd flktfspdvf rffclrssyr saidysdsam
      361 lqaqqlllgl gsfledaray mkgqlacgsv reamlwerls stkravkaal addfdtprvv
      421 dailglahhg ngqlraslkk pgerpd
//
LOCUS       XP_011519420             362 aa            linear   PRI 05-AUG-2025
DEFINITION  putative cysteine--tRNA ligase, mitochondrial isoform X5 [Homo
            sapiens].
ACCESSION   XP_011519420
VERSION     XP_011519420.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521118.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..362
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..362
                     /product="putative cysteine--tRNA ligase, mitochondrial
                     isoform X5"
                     /calculated_mol_wt=39944
     Region          35..>306
                     /region_name="PTZ00399"
                     /note="cysteinyl-tRNA-synthetase; Provisional"
                     /db_xref="CDD:240402"
     CDS             1..362
                     /gene="CARS2"
                     /gene_synonym="COXPD27; cysRS"
                     /coded_by="XM_011521118.4:24..1112"
                     /db_xref="GeneID:79587"
                     /db_xref="HGNC:HGNC:25695"
                     /db_xref="MIM:612800"
ORIGIN      
        1 mlrttrgpgl gppllqaalg lgragwhwpa graasggrgr awlqptgret gvqvynsltg
       61 rkeplivaha eaaswyscgp tvydhahlgh acsyvrfdii rriltkvfgc sivmvmgitd
      121 vddkiikran emnispasla slyeedfkqd maalkvlppt vylrvtenip qiisfiegii
      181 argnaystak gnvyfdlksr gdkygklvgv vpgpvgepad sdkrhasdfa lwkaakpqev
      241 fwaspwgpgr pgwhiecsai asmvfgsqld ihsggidlaf phheneiaqc evfhqceqwg
      301 nyflhsavcs qkwmqhhels ntsnpavlef twmhwksris kftgsrltsl itfwgwtakg
      361 mk
//
LOCUS       XP_047286564             358 aa            linear   PRI 05-AUG-2025
DEFINITION  putative cysteine--tRNA ligase, mitochondrial isoform X6 [Homo
            sapiens].
ACCESSION   XP_047286564
VERSION     XP_047286564.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430608.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..358
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..358
                     /product="putative cysteine--tRNA ligase, mitochondrial
                     isoform X6"
                     /calculated_mol_wt=39145
     Region          35..>329
                     /region_name="PTZ00399"
                     /note="cysteinyl-tRNA-synthetase; Provisional"
                     /db_xref="CDD:240402"
     CDS             1..358
                     /gene="CARS2"
                     /gene_synonym="COXPD27; cysRS"
                     /coded_by="XM_047430608.1:24..1100"
                     /db_xref="GeneID:79587"
                     /db_xref="HGNC:HGNC:25695"
                     /db_xref="MIM:612800"
ORIGIN      
        1 mlrttrgpgl gppllqaalg lgragwhwpa graasggrgr awlqptgret gvqvynsltg
       61 rkeplivaha eaaswyscgp tvydhahlgh acsyvrfdii rriltkvfgc sivmvmgitd
      121 vddkiikran emnispasla slyeedfkqd maalkvlppt vylrvtenip qiisfiegii
      181 argnaystak gnvyfdlksr gdkygklvgv vpgpvgepad sdkrhasdfa lwkaakpqev
      241 fwaspwgpgr pgwhiecsai asmvfgsqld ihsggidlaf phheneiaqc evfhqceqwg
      301 nyflhsghlh akgkeekmsk slknyitikp sttvtapcsk lsscswgwal swrthvpt
//
LOCUS       XP_016876231             358 aa            linear   PRI 05-AUG-2025
DEFINITION  putative cysteine--tRNA ligase, mitochondrial isoform X6 [Homo
            sapiens].
ACCESSION   XP_016876231
VERSION     XP_016876231.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020742.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..358
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..358
                     /product="putative cysteine--tRNA ligase, mitochondrial
                     isoform X6"
                     /calculated_mol_wt=39145
     Region          35..>329
                     /region_name="PTZ00399"
                     /note="cysteinyl-tRNA-synthetase; Provisional"
                     /db_xref="CDD:240402"
     CDS             1..358
                     /gene="CARS2"
                     /gene_synonym="COXPD27; cysRS"
                     /coded_by="XM_017020742.3:24..1100"
                     /db_xref="GeneID:79587"
                     /db_xref="HGNC:HGNC:25695"
                     /db_xref="MIM:612800"
ORIGIN      
        1 mlrttrgpgl gppllqaalg lgragwhwpa graasggrgr awlqptgret gvqvynsltg
       61 rkeplivaha eaaswyscgp tvydhahlgh acsyvrfdii rriltkvfgc sivmvmgitd
      121 vddkiikran emnispasla slyeedfkqd maalkvlppt vylrvtenip qiisfiegii
      181 argnaystak gnvyfdlksr gdkygklvgv vpgpvgepad sdkrhasdfa lwkaakpqev
      241 fwaspwgpgr pgwhiecsai asmvfgsqld ihsggidlaf phheneiaqc evfhqceqwg
      301 nyflhsghlh akgkeekmsk slknyitikp sttvtapcsk lsscswgwal swrthvpt
//
LOCUS       XP_047286565             302 aa            linear   PRI 05-AUG-2025
DEFINITION  putative cysteine--tRNA ligase, mitochondrial isoform X7 [Homo
            sapiens].
ACCESSION   XP_047286565
VERSION     XP_047286565.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430609.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..302
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..302
                     /product="putative cysteine--tRNA ligase, mitochondrial
                     isoform X7"
                     /calculated_mol_wt=33642
     Region          <2..301
                     /region_name="PTZ00399"
                     /note="cysteinyl-tRNA-synthetase; Provisional"
                     /db_xref="CDD:240402"
     CDS             1..302
                     /gene="CARS2"
                     /gene_synonym="COXPD27; cysRS"
                     /coded_by="XM_047430609.1:302..1210"
                     /db_xref="GeneID:79587"
                     /db_xref="HGNC:HGNC:25695"
                     /db_xref="MIM:612800"
ORIGIN      
        1 mvfgsqldih sggidlafph heneiaqcev fhqceqwgny flhsghlhak gkeekmsksl
       61 knyitikdfl ktfspdvfrf fclrssyrsa idysdsamlq aqqlllglgs fledaraymk
      121 gqlacgsvre amlwerlsst kravkaalad dfdtprvvda ilglahhgng qlraslkepe
      181 gprspavfga iisyfeqffe tvgislanqq yvsgdgseat lhgvvdelvr frqkvrqfal
      241 ampeatgdar rqqllerqpl leacdtlrrg ltahginikd rssttstwel ldqrtkdqks
      301 ag
//
LOCUS       XP_011533527             649 aa            linear   PRI 05-AUG-2025
DEFINITION  ORC ubiquitin ligase 1 isoform X1 [Homo sapiens].
ACCESSION   XP_011533527
VERSION     XP_011533527.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535225.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..649
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..649
                     /product="ORC ubiquitin ligase 1 isoform X1"
                     /calculated_mol_wt=72569
     Region          14..>189
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..649
                     /gene="OBI1"
                     /gene_synonym="C13orf7; RNF219"
                     /coded_by="XM_011535225.2:131..2080"
                     /db_xref="GeneID:79596"
                     /db_xref="HGNC:HGNC:20308"
                     /db_xref="MIM:615906"
ORIGIN      
        1 mlshtvrkhl rktrlellhk eyedeidclq keveelkskn lslesqikti ldpltlvqgn
       61 qnedkhlvtd npskinpetv aewkkklrta neiyekvkdd vdklkeankk lklengglvr
      121 enlrlkaevd nrspqkfgrf avaalqskve qyeretnrlk kalersdkyi eelesqvaql
      181 knsseekeam nsicqtalsa dgkgskgsee dvvsknqgds arkqpgssts ssshlakpss
      241 srlcdtssar qestskadln csknkdlyqe qvevmldvtd tsmdtylere wgnkpsdcvp
      301 ykdeelydlp apctplslsc lqlstpenre ssvvqaggsk khsnhlrklv fddfcdssnv
      361 snkdsseddi srsenekkse cfsspktgfw dccstsyaqn ldfessegnt iansvgeiss
      421 klseksglcl skrlnsirsf emnrtrtsse asmdaayldk iseldsmmse sdnskspcnn
      481 gfksldldgl skssqgsefl eepdkleekt elnlskgslt ndqlengsew kptsffllsp
      541 sdqemnedfs lhssscpvtn eikppsclfq tefsqgills sshrlfedqr fgsslfkmss
      601 emhslhnhlq spwstsfvpe krnknvnqst krkiqsslss aspskatks
//
LOCUS       XP_024305178             649 aa            linear   PRI 05-AUG-2025
DEFINITION  ORC ubiquitin ligase 1 isoform X1 [Homo sapiens].
ACCESSION   XP_024305178
VERSION     XP_024305178.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449410.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..649
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..649
                     /product="ORC ubiquitin ligase 1 isoform X1"
                     /calculated_mol_wt=72569
     Region          14..>189
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..649
                     /gene="OBI1"
                     /gene_synonym="C13orf7; RNF219"
                     /coded_by="XM_024449410.2:551..2500"
                     /db_xref="GeneID:79596"
                     /db_xref="HGNC:HGNC:20308"
                     /db_xref="MIM:615906"
ORIGIN      
        1 mlshtvrkhl rktrlellhk eyedeidclq keveelkskn lslesqikti ldpltlvqgn
       61 qnedkhlvtd npskinpetv aewkkklrta neiyekvkdd vdklkeankk lklengglvr
      121 enlrlkaevd nrspqkfgrf avaalqskve qyeretnrlk kalersdkyi eelesqvaql
      181 knsseekeam nsicqtalsa dgkgskgsee dvvsknqgds arkqpgssts ssshlakpss
      241 srlcdtssar qestskadln csknkdlyqe qvevmldvtd tsmdtylere wgnkpsdcvp
      301 ykdeelydlp apctplslsc lqlstpenre ssvvqaggsk khsnhlrklv fddfcdssnv
      361 snkdsseddi srsenekkse cfsspktgfw dccstsyaqn ldfessegnt iansvgeiss
      421 klseksglcl skrlnsirsf emnrtrtsse asmdaayldk iseldsmmse sdnskspcnn
      481 gfksldldgl skssqgsefl eepdkleekt elnlskgslt ndqlengsew kptsffllsp
      541 sdqemnedfs lhssscpvtn eikppsclfq tefsqgills sshrlfedqr fgsslfkmss
      601 emhslhnhlq spwstsfvpe krnknvnqst krkiqsslss aspskatks
//
LOCUS       XP_006719929             804 aa            linear   PRI 05-AUG-2025
DEFINITION  N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform X1
            [Homo sapiens].
ACCESSION   XP_006719929
VERSION     XP_006719929.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006719866.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..804
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..804
                     /product="N-alpha-acetyltransferase 16, NatA auxiliary
                     subunit isoform X1"
                     /calculated_mol_wt=94269
     Region          13..38
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          21..243
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          47..74
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          82..108
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(84..85,88..89,91,115,118..119,122..123,125..126,149,
                     152..153,156..157,160)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          113..143
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          148..173
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          187..638
                     /region_name="NatA_aux_su"
                     /note="N-terminal acetyltransferase A, auxiliary subunit;
                     pfam12569"
                     /db_xref="CDD:463630"
     Site            order(318..319,322..323,325,349,352..353,356..357,
                     359..360,383,386..387,390..391,394)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          318..342
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          347..377
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          382..407
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..804
                     /gene="NAA16"
                     /gene_synonym="NARG1L"
                     /coded_by="XM_006719866.4:263..2677"
                     /db_xref="GeneID:79612"
                     /db_xref="HGNC:HGNC:26164"
                     /db_xref="MIM:619497"
ORIGIN      
        1 mpnvllppke snlfkrilkc yeqkqykngl kfckmilsnp kfaehgetla mkgltlnclg
       61 kkeeayefvr kglrndvksh vcwhvygllq rsdkkydeai kcyrnalkld kdnlqilrdl
      121 sllqiqmrdl egyretryql lqlrptqras wigyaiayhl lkdydmalkl leefrqtqqv
      181 ppnkidyeys elilyqnqvm readllqesl ehiemyekqi cdkllveeik geillklgrl
      241 keasevfknl idrnaenwcy yeglekalqi stleerlqiy eeiskqhpka itprrlpltl
      301 vpengekepp ttllwvqyfl aqhfdklgqy slaldyinaa iastptliel fymkakiykh
      361 ignlkeaakw mdeaqsldta drfinskcak ymlranmike aeemcskftr egtsamenln
      421 emqcmwfqte cisayqrlgr ygdalkkche verhffeitd dqfdfhtycm rkmtlrayvd
      481 llrledilrr hafyfkaars aieiylklyd npltneskqq einsenlsak elkkmlskqr
      541 raqkkaklee erkhaererq qknqkkkrde eeeeasglke elipeklerv enpleeavkf
      601 liplknlvad nidthllafe iyfrkgkfll mlqsvkrafa insnnpwlhe clirfsksvs
      661 nhsnlpdivs kvlsqemqki fvkkdlesfn edflkrnats lqhllsgakm myfldksrqe
      721 kaiaiatrld etikdkdvkt likvsealld gsfgncssqy eeyrmachnl lpftsaflpa
      781 vnevdnpnva lnhtanydvl anei
//
LOCUS       XP_047286566             738 aa            linear   PRI 05-AUG-2025
DEFINITION  N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform X2
            [Homo sapiens].
ACCESSION   XP_047286566
VERSION     XP_047286566.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430610.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..738
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..738
                     /product="N-alpha-acetyltransferase 16, NatA auxiliary
                     subunit isoform X2"
                     /calculated_mol_wt=86559
     Region          61..572
                     /region_name="NatA_aux_su"
                     /note="N-terminal acetyltransferase A, auxiliary subunit;
                     pfam12569"
                     /db_xref="CDD:463630"
     Site            order(252..253,256..257,259,283,286..287,290..291,
                     293..294,317,320..321,324..325,328)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          252..276
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          281..311
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          316..341
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..738
                     /gene="NAA16"
                     /gene_synonym="NARG1L"
                     /coded_by="XM_047430610.1:364..2580"
                     /db_xref="GeneID:79612"
                     /db_xref="HGNC:HGNC:26164"
                     /db_xref="MIM:619497"
ORIGIN      
        1 mrdlegyret ryqllqlrpt qraswigyai ayhllkdydm alklleefrq tqqvppnkid
       61 yeyselilyq nqvmreadll qeslehiemy ekqicdkllv eeikgeillk lgrlkeasev
      121 fknlidrnae nwcyyeglek alqistleer lqiyeeiskq hpkaitprrl pltlvpgerf
      181 relmdkflrv nfskgcpplf ttlkslyynt ekvsiiqelv tnyeaslktc dffspyenge
      241 keppttllwv qyflaqhfdk lgqyslaldy inaaiastpt lielfymkak iykhignlke
      301 aakwmdeaqs ldtadrfins kcakymlran mikeaeemcs kftregtsam enlnemqcmw
      361 fqtecisayq rlgrygdalk kcheverhff eitddqfdfh tycmrkmtlr ayvdllrled
      421 ilrrhafyfk aarsaieiyl klydnpltne skqqeinsen lsakelkkml skqrraqkka
      481 kleeerkhae rerqqknqkk krdeeeeeas glkeelipek lervenplee avkfliplkn
      541 lvadnidthl lafeiyfrkg kfllmlqsvk rafainsnnp wlheclirfs ksvsnhsnlp
      601 divskvlsqe mqkifvkkdl esfnedflkr natslqhlls gakmmyfldk srqekaiaia
      661 trldetikdk dvktlikvse alldgsfgnc ssqyeeyrma chnllpftsa flpavnevdn
      721 pnvalnhtan ydvlanei
//
LOCUS       XP_011533530             530 aa            linear   PRI 05-AUG-2025
DEFINITION  N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform X3
            [Homo sapiens].
ACCESSION   XP_011533530
VERSION     XP_011533530.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535228.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..530
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..530
                     /product="N-alpha-acetyltransferase 16, NatA auxiliary
                     subunit isoform X3"
                     /calculated_mol_wt=62169
     Region          13..38
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          21..243
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          47..74
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          82..108
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(84..85,88..89,91,115,118..119,122..123,125..126,149,
                     152..153,156..157,160)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          113..143
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          148..173
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          187..>514
                     /region_name="NatA_aux_su"
                     /note="N-terminal acetyltransferase A, auxiliary subunit;
                     pfam12569"
                     /db_xref="CDD:463630"
     Site            order(378..379,382..383,385,409,412..413,416..417,
                     419..420,443,446..447,450..451,454)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          378..402
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          407..437
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          442..467
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..530
                     /gene="NAA16"
                     /gene_synonym="NARG1L"
                     /coded_by="XM_011535228.3:263..1855"
                     /db_xref="GeneID:79612"
                     /db_xref="HGNC:HGNC:26164"
                     /db_xref="MIM:619497"
ORIGIN      
        1 mpnvllppke snlfkrilkc yeqkqykngl kfckmilsnp kfaehgetla mkgltlnclg
       61 kkeeayefvr kglrndvksh vcwhvygllq rsdkkydeai kcyrnalkld kdnlqilrdl
      121 sllqiqmrdl egyretryql lqlrptqras wigyaiayhl lkdydmalkl leefrqtqqv
      181 ppnkidyeys elilyqnqvm readllqesl ehiemyekqi cdkllveeik geillklgrl
      241 keasevfknl idrnaenwcy yeglekalqi stleerlqiy eeiskqhpka itprrlpltl
      301 vpgerfrelm dkflrvnfsk gcpplfttlk slyyntekvs iiqelvtnye aslktcdffs
      361 pyengekepp ttllwvqyfl aqhfdklgqy slaldyinaa iastptliel fymkakiykh
      421 ignlkeaakw mdeaqsldta drfinskcak ymlranmike aeemcskftr egtsamenln
      481 emqcmwfqte cisayqrlgr ygdalkkche verhspstwt tggkepqmhp
//
LOCUS       XP_047286567             382 aa            linear   PRI 05-AUG-2025
DEFINITION  N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform X4
            [Homo sapiens].
ACCESSION   XP_047286567
VERSION     XP_047286567.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430611.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..382
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..382
                     /product="N-alpha-acetyltransferase 16, NatA auxiliary
                     subunit isoform X4"
                     /calculated_mol_wt=45334
     Region          13..38
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          21..243
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          47..74
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          82..108
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(84..85,88..89,91,115,118..119,122..123,125..126,149,
                     152..153,156..157,160)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          113..143
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          148..173
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          187..>339
                     /region_name="NatA_aux_su"
                     /note="N-terminal acetyltransferase A, auxiliary subunit;
                     pfam12569"
                     /db_xref="CDD:463630"
     CDS             1..382
                     /gene="NAA16"
                     /gene_synonym="NARG1L"
                     /coded_by="XM_047430611.1:263..1411"
                     /db_xref="GeneID:79612"
                     /db_xref="HGNC:HGNC:26164"
                     /db_xref="MIM:619497"
ORIGIN      
        1 mpnvllppke snlfkrilkc yeqkqykngl kfckmilsnp kfaehgetla mkgltlnclg
       61 kkeeayefvr kglrndvksh vcwhvygllq rsdkkydeai kcyrnalkld kdnlqilrdl
      121 sllqiqmrdl egyretryql lqlrptqras wigyaiayhl lkdydmalkl leefrqtqqv
      181 ppnkidyeys elilyqnqvm readllqesl ehiemyekqi cdkllveeik geillklgrl
      241 keasevfknl idrnaenwcy yeglekalqi stleerlqiy eeiskqhpka itprrlpltl
      301 vpgerfrelm dkflrvnfsk gcpplfttlk slyyntekrm grrnprqhys gfsiswhstl
      361 inldsilwlw iilmlqllvl ql
//
LOCUS       XP_016876234             357 aa            linear   PRI 05-AUG-2025
DEFINITION  N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform X5
            [Homo sapiens].
ACCESSION   XP_016876234
VERSION     XP_016876234.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020745.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..357
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..357
                     /product="N-alpha-acetyltransferase 16, NatA auxiliary
                     subunit isoform X5"
                     /calculated_mol_wt=42089
     Region          13..38
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          21..243
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          47..74
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          82..108
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(84..85,88..89,91,115,118..119,122..123,125..126,149,
                     152..153,156..157,160)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          113..143
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          148..173
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          187..>298
                     /region_name="NatA_aux_su"
                     /note="N-terminal acetyltransferase A, auxiliary subunit;
                     pfam12569"
                     /db_xref="CDD:463630"
     CDS             1..357
                     /gene="NAA16"
                     /gene_synonym="NARG1L"
                     /coded_by="XM_017020745.3:263..1336"
                     /db_xref="GeneID:79612"
                     /db_xref="HGNC:HGNC:26164"
                     /db_xref="MIM:619497"
ORIGIN      
        1 mpnvllppke snlfkrilkc yeqkqykngl kfckmilsnp kfaehgetla mkgltlnclg
       61 kkeeayefvr kglrndvksh vcwhvygllq rsdkkydeai kcyrnalkld kdnlqilrdl
      121 sllqiqmrdl egyretryql lqlrptqras wigyaiayhl lkdydmalkl leefrqtqqv
      181 ppnkidyeys elilyqnqvm readllqesl ehiemyekqi cdkllveeik geillklgrl
      241 keasevfknl idrnaenwcy yeglekalqi stleerlqiy eeiskqhpka itprrlpltl
      301 vpeifhdpkk kphtyftpch psttapgnhk stfctygfvc fwtfeingii pyvvfsf
//
LOCUS       XP_047286568             352 aa            linear   PRI 05-AUG-2025
DEFINITION  N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform X6
            [Homo sapiens].
ACCESSION   XP_047286568
VERSION     XP_047286568.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430612.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..352
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..352
                     /product="N-alpha-acetyltransferase 16, NatA auxiliary
                     subunit isoform X6"
                     /calculated_mol_wt=41595
     Region          13..38
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          21..243
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          47..74
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          82..108
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(84..85,88..89,91,115,118..119,122..123,125..126,149,
                     152..153,156..157,160)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          113..143
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          148..173
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          187..>298
                     /region_name="NatA_aux_su"
                     /note="N-terminal acetyltransferase A, auxiliary subunit;
                     pfam12569"
                     /db_xref="CDD:463630"
     CDS             1..352
                     /gene="NAA16"
                     /gene_synonym="NARG1L"
                     /coded_by="XM_047430612.1:263..1321"
                     /db_xref="GeneID:79612"
                     /db_xref="HGNC:HGNC:26164"
                     /db_xref="MIM:619497"
ORIGIN      
        1 mpnvllppke snlfkrilkc yeqkqykngl kfckmilsnp kfaehgetla mkgltlnclg
       61 kkeeayefvr kglrndvksh vcwhvygllq rsdkkydeai kcyrnalkld kdnlqilrdl
      121 sllqiqmrdl egyretryql lqlrptqras wigyaiayhl lkdydmalkl leefrqtqqv
      181 ppnkidyeys elilyqnqvm readllqesl ehiemyekqi cdkllveeik geillklgrl
      241 keasevfknl idrnaenwcy yeglekalqi stleerlqiy eeiskqhpka itprrlpltl
      301 vpvyfpedih cdqlmvysst ntlcmcepky vweiclrspp plcflqkcsn md
//
LOCUS       XP_016876235             338 aa            linear   PRI 05-AUG-2025
DEFINITION  N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform X7
            [Homo sapiens].
ACCESSION   XP_016876235
VERSION     XP_016876235.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020746.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..338
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..338
                     /product="N-alpha-acetyltransferase 16, NatA auxiliary
                     subunit isoform X7"
                     /calculated_mol_wt=40032
     Region          13..38
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          21..243
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          47..74
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          82..108
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(84..85,88..89,91,115,118..119,122..123,125..126,149,
                     152..153,156..157,160)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          113..143
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          148..173
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          187..>338
                     /region_name="NatA_aux_su"
                     /note="N-terminal acetyltransferase A, auxiliary subunit;
                     pfam12569"
                     /db_xref="CDD:463630"
     CDS             1..338
                     /gene="NAA16"
                     /gene_synonym="NARG1L"
                     /coded_by="XM_017020746.3:263..1279"
                     /db_xref="GeneID:79612"
                     /db_xref="HGNC:HGNC:26164"
                     /db_xref="MIM:619497"
ORIGIN      
        1 mpnvllppke snlfkrilkc yeqkqykngl kfckmilsnp kfaehgetla mkgltlnclg
       61 kkeeayefvr kglrndvksh vcwhvygllq rsdkkydeai kcyrnalkld kdnlqilrdl
      121 sllqiqmrdl egyretryql lqlrptqras wigyaiayhl lkdydmalkl leefrqtqqv
      181 ppnkidyeys elilyqnqvm readllqesl ehiemyekqi cdkllveeik geillklgrl
      241 keasevfknl idrnaenwcy yeglekalqi stleerlqiy eeiskqhpka itprrlpltl
      301 vpgerfrelm dkflrvnfsk gcpplfttlk slyyntek
//
LOCUS       XP_006719930             306 aa            linear   PRI 05-AUG-2025
DEFINITION  ribonuclease H2 subunit B isoform X1 [Homo sapiens].
ACCESSION   XP_006719930
VERSION     XP_006719930.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006719867.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..306
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..306
                     /product="ribonuclease H2 subunit B isoform X1"
                     /calculated_mol_wt=34543
     Region          29..296
                     /region_name="RNase_H2-B"
                     /note="Ribonuclease H2-B is a subunit of the eukaryotic
                     RNase H complex which cleaves RNA-DNA hybrids; cd09270"
                     /db_xref="CDD:187751"
     CDS             1..306
                     /gene="RNASEH2B"
                     /gene_synonym="AGS2; DLEU8"
                     /coded_by="XM_006719867.5:147..1067"
                     /db_xref="GeneID:79621"
                     /db_xref="HGNC:HGNC:25671"
                     /db_xref="MIM:610326"
ORIGIN      
        1 mtqlkefglg sasqkeylkd askkmknglm fvklvnpcsg egaiylfnmc lqqlfevkvf
       61 kekhhswfin qsvqsggllh fatpvdplfl llhylikadk egkfqpldqv vvdnvfpnci
      121 lllklpglek llhhvteekg npeidnkkyy kyskektlkw lekkvnqtva alktnnvnvs
      181 srvqstaffs gdqastdkee dyiryahgli sdyipkelsd dlskylklpe psaslpnpps
      241 kkiklsdepv eakedytkfn tkdlktekkn skmtaaqkal akvdksgmks idtffgvknk
      301 kkigkv
//
LOCUS       XP_047286569             284 aa            linear   PRI 05-AUG-2025
DEFINITION  ribonuclease H2 subunit B isoform X2 [Homo sapiens].
ACCESSION   XP_047286569
VERSION     XP_047286569.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430613.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..284
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..284
                     /product="ribonuclease H2 subunit B isoform X2"
                     /calculated_mol_wt=32054
     Region          17..>187
                     /region_name="RNase_H2-B"
                     /note="Ribonuclease H2-B is a subunit of the eukaryotic
                     RNase H complex which cleaves RNA-DNA hybrids; cd09270"
                     /db_xref="CDD:187751"
     Site            order(19..21,39,63,71..75)
                     /site_type="other"
                     /note="heterotrimeric interface"
                     /db_xref="CDD:187751"
     CDS             1..284
                     /gene="RNASEH2B"
                     /gene_synonym="AGS2; DLEU8"
                     /coded_by="XM_047430613.1:400..1254"
                     /db_xref="GeneID:79621"
                     /db_xref="HGNC:HGNC:25671"
                     /db_xref="MIM:610326"
ORIGIN      
        1 maagvdcgdg vgarqhvflv seylkdaskk mknglmfvkl vnpcsgegai ylfnmclqql
       61 fevkvfkekh hswfinqsvq sggllhfatp vdplflllhy likadkegkf qpldqvvvdn
      121 vfpncilllk lpglekllhh vteekgnpei dnkkyykysk ektlkwlekk vnqtvaalkt
      181 nnvnvssrvq staffsgdqa stdkeedyir yahglisdyi pkelsddlsk ylklpepsas
      241 lpnppskkik lsdepveake dytkfntkdl ktekmaaqrq krgk
//
LOCUS       XP_047286570             282 aa            linear   PRI 05-AUG-2025
DEFINITION  ribonuclease H2 subunit B isoform X3 [Homo sapiens].
ACCESSION   XP_047286570
VERSION     XP_047286570.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430614.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..282
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..282
                     /product="ribonuclease H2 subunit B isoform X3"
                     /calculated_mol_wt=31873
     Region          5..272
                     /region_name="RNase_H2-B"
                     /note="Ribonuclease H2-B is a subunit of the eukaryotic
                     RNase H complex which cleaves RNA-DNA hybrids; cd09270"
                     /db_xref="CDD:187751"
     CDS             1..282
                     /gene="RNASEH2B"
                     /gene_synonym="AGS2; DLEU8"
                     /coded_by="XM_047430614.1:142..990"
                     /db_xref="GeneID:79621"
                     /db_xref="HGNC:HGNC:25671"
                     /db_xref="MIM:610326"
ORIGIN      
        1 mknglmfvkl vnpcsgegai ylfnmclqql fevkvfkekh hswfinqsvq sggllhfatp
       61 vdplflllhy likadkegkf qpldqvvvdn vfpncilllk lpglekllhh vteekgnpei
      121 dnkkyykysk ektlkwlekk vnqtvaalkt nnvnvssrvq staffsgdqa stdkeedyir
      181 yahglisdyi pkelsddlsk ylklpepsas lpnppskkik lsdepveake dytkfntkdl
      241 ktekknskmt aaqkalakvd ksgmksidtf fgvknkkkig kv
//
LOCUS       XP_047286571             282 aa            linear   PRI 05-AUG-2025
DEFINITION  ribonuclease H2 subunit B isoform X3 [Homo sapiens].
ACCESSION   XP_047286571
VERSION     XP_047286571.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430615.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..282
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..282
                     /product="ribonuclease H2 subunit B isoform X3"
                     /calculated_mol_wt=31873
     Region          5..272
                     /region_name="RNase_H2-B"
                     /note="Ribonuclease H2-B is a subunit of the eukaryotic
                     RNase H complex which cleaves RNA-DNA hybrids; cd09270"
                     /db_xref="CDD:187751"
     CDS             1..282
                     /gene="RNASEH2B"
                     /gene_synonym="AGS2; DLEU8"
                     /coded_by="XM_047430615.1:216..1064"
                     /db_xref="GeneID:79621"
                     /db_xref="HGNC:HGNC:25671"
                     /db_xref="MIM:610326"
ORIGIN      
        1 mknglmfvkl vnpcsgegai ylfnmclqql fevkvfkekh hswfinqsvq sggllhfatp
       61 vdplflllhy likadkegkf qpldqvvvdn vfpncilllk lpglekllhh vteekgnpei
      121 dnkkyykysk ektlkwlekk vnqtvaalkt nnvnvssrvq staffsgdqa stdkeedyir
      181 yahglisdyi pkelsddlsk ylklpepsas lpnppskkik lsdepveake dytkfntkdl
      241 ktekknskmt aaqkalakvd ksgmksidtf fgvknkkkig kv
//
LOCUS       XP_047286572             282 aa            linear   PRI 05-AUG-2025
DEFINITION  ribonuclease H2 subunit B isoform X3 [Homo sapiens].
ACCESSION   XP_047286572
VERSION     XP_047286572.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430616.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..282
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..282
                     /product="ribonuclease H2 subunit B isoform X3"
                     /calculated_mol_wt=31873
     Region          5..272
                     /region_name="RNase_H2-B"
                     /note="Ribonuclease H2-B is a subunit of the eukaryotic
                     RNase H complex which cleaves RNA-DNA hybrids; cd09270"
                     /db_xref="CDD:187751"
     CDS             1..282
                     /gene="RNASEH2B"
                     /gene_synonym="AGS2; DLEU8"
                     /coded_by="XM_047430616.1:49..897"
                     /db_xref="GeneID:79621"
                     /db_xref="HGNC:HGNC:25671"
                     /db_xref="MIM:610326"
ORIGIN      
        1 mknglmfvkl vnpcsgegai ylfnmclqql fevkvfkekh hswfinqsvq sggllhfatp
       61 vdplflllhy likadkegkf qpldqvvvdn vfpncilllk lpglekllhh vteekgnpei
      121 dnkkyykysk ektlkwlekk vnqtvaalkt nnvnvssrvq staffsgdqa stdkeedyir
      181 yahglisdyi pkelsddlsk ylklpepsas lpnppskkik lsdepveake dytkfntkdl
      241 ktekknskmt aaqkalakvd ksgmksidtf fgvknkkkig kv
//
LOCUS       XP_011533532             261 aa            linear   PRI 05-AUG-2025
DEFINITION  ribonuclease H2 subunit B isoform X4 [Homo sapiens].
ACCESSION   XP_011533532
VERSION     XP_011533532.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535230.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..261
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..261
                     /product="ribonuclease H2 subunit B isoform X4"
                     /calculated_mol_wt=29038
     Region          17..>187
                     /region_name="RNase_H2-B"
                     /note="Ribonuclease H2-B is a subunit of the eukaryotic
                     RNase H complex which cleaves RNA-DNA hybrids; cd09270"
                     /db_xref="CDD:187751"
     Site            order(19..21,39,63,71..75)
                     /site_type="other"
                     /note="heterotrimeric interface"
                     /db_xref="CDD:187751"
     CDS             1..261
                     /gene="RNASEH2B"
                     /gene_synonym="AGS2; DLEU8"
                     /coded_by="XM_011535230.3:400..1185"
                     /db_xref="GeneID:79621"
                     /db_xref="HGNC:HGNC:25671"
                     /db_xref="MIM:610326"
ORIGIN      
        1 maagvdcgdg vgarqhvflv seylkdaskk mknglmfvkl vnpcsgegai ylfnmclqql
       61 fevkvfkekh hswfinqsvq sggllhfatp vdplflllhy likadkegkf qpldqvvvdn
      121 vfpncilllk lpglekllhh vteekgnpei dnkkyykysk ektlkwlekk vnqtvaalkt
      181 nnvnvssrvq staffsgdqa stdkeedyir yahglisdyi pkelsddlsk ylklpepsas
      241 lpnppskaat hsssaagmfi s
//
LOCUS       XP_011533533             259 aa            linear   PRI 05-AUG-2025
DEFINITION  ribonuclease H2 subunit B isoform X5 [Homo sapiens].
ACCESSION   XP_011533533
VERSION     XP_011533533.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535231.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..259
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..259
                     /product="ribonuclease H2 subunit B isoform X5"
                     /calculated_mol_wt=29180
     Region          17..>187
                     /region_name="RNase_H2-B"
                     /note="Ribonuclease H2-B is a subunit of the eukaryotic
                     RNase H complex which cleaves RNA-DNA hybrids; cd09270"
                     /db_xref="CDD:187751"
     Site            order(19..21,39,63,71..75)
                     /site_type="other"
                     /note="heterotrimeric interface"
                     /db_xref="CDD:187751"
     CDS             1..259
                     /gene="RNASEH2B"
                     /gene_synonym="AGS2; DLEU8"
                     /coded_by="XM_011535231.3:400..1179"
                     /db_xref="GeneID:79621"
                     /db_xref="HGNC:HGNC:25671"
                     /db_xref="MIM:610326"
ORIGIN      
        1 maagvdcgdg vgarqhvflv seylkdaskk mknglmfvkl vnpcsgegai ylfnmclqql
       61 fevkvfkekh hswfinqsvq sggllhfatp vdplflllhy likadkegkf qpldqvvvdn
      121 vfpncilllk lpglekllhh vteekgnpei dnkkyykysk ektlkwlekk vnqtvaalkt
      181 nnvnvssrvq staffsgdqa stdkeedyir yahglisdyi pkelsddlsk ylklpepsas
      241 lpnppskiqr mekpiinht
//
LOCUS       XP_047286573             258 aa            linear   PRI 05-AUG-2025
DEFINITION  ribonuclease H2 subunit B isoform X6 [Homo sapiens].
ACCESSION   XP_047286573
VERSION     XP_047286573.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430617.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..258
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..258
                     /product="ribonuclease H2 subunit B isoform X6"
                     /calculated_mol_wt=28855
     Region          17..>187
                     /region_name="RNase_H2-B"
                     /note="Ribonuclease H2-B is a subunit of the eukaryotic
                     RNase H complex which cleaves RNA-DNA hybrids; cd09270"
                     /db_xref="CDD:187751"
     Site            order(19..21,39,63,71..75)
                     /site_type="other"
                     /note="heterotrimeric interface"
                     /db_xref="CDD:187751"
     CDS             1..258
                     /gene="RNASEH2B"
                     /gene_synonym="AGS2; DLEU8"
                     /coded_by="XM_047430617.1:400..1176"
                     /db_xref="GeneID:79621"
                     /db_xref="HGNC:HGNC:25671"
                     /db_xref="MIM:610326"
ORIGIN      
        1 maagvdcgdg vgarqhvflv seylkdaskk mknglmfvkl vnpcsgegai ylfnmclqql
       61 fevkvfkekh hswfinqsvq sggllhfatp vdplflllhy likadkegkf qpldqvvvdn
      121 vfpncilllk lpglekllhh vteekgnpei dnkkyykysk ektlkwlekk vnqtvaalkt
      181 nnvnvssrvq staffsgdqa stdkeedyir yahglisdyi pkelsddlsk ylklpepsas
      241 lpnppsklgl ptghfvks
//
LOCUS       XP_047286574             176 aa            linear   PRI 05-AUG-2025
DEFINITION  ribonuclease H2 subunit B isoform X7 [Homo sapiens].
ACCESSION   XP_047286574
VERSION     XP_047286574.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430618.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..176
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..176
                     /product="ribonuclease H2 subunit B isoform X7"
                     /calculated_mol_wt=19750
     Region          <26..92
                     /region_name="RNase_H2-B"
                     /note="Ribonuclease H2-B is a subunit of the eukaryotic
                     RNase H complex which cleaves RNA-DNA hybrids; cl18968"
                     /db_xref="CDD:418515"
     Region          <111..166
                     /region_name="RNase_H2-B"
                     /note="Ribonuclease H2-B is a subunit of the eukaryotic
                     RNase H complex which cleaves RNA-DNA hybrids; cl18968"
                     /db_xref="CDD:418515"
     CDS             1..176
                     /gene="RNASEH2B"
                     /gene_synonym="AGS2; DLEU8"
                     /coded_by="XM_047430618.1:177..707"
                     /db_xref="GeneID:79621"
                     /db_xref="HGNC:HGNC:25671"
                     /db_xref="MIM:610326"
ORIGIN      
        1 mgsfhfpskg npeidnkkyy kyskektlkw lekkvnqtva alktnnvnvs srvqstaffs
       61 gdqastdkee dyiryahgli sdyipkelsd dlskylklpe psaslpnpps kkiklsdepv
      121 eakedytkfn tkdlktekkn skmtaaqkal akvdksgmks idtffgvknk kkigkv
//
LOCUS       XP_047286575             346 aa            linear   PRI 05-AUG-2025
DEFINITION  dehydrogenase/reductase SDR family member 12 isoform X1 [Homo
            sapiens].
ACCESSION   XP_047286575
VERSION     XP_047286575.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430619.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..346
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..346
                     /product="dehydrogenase/reductase SDR family member 12
                     isoform X1"
                     /calculated_mol_wt=38416
     Region          40..>261
                     /region_name="Rossmann-fold NAD(P)(+)-binding proteins"
                     /note="A large family of proteins that share a
                     Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The
                     NADB domain is found in numerous dehydrogenases of
                     metabolic pathways such as glycolysis, and many other
                     redox enzymes. NAD binding involves numerous...; cl21454"
                     /db_xref="CDD:473865"
     Site            order(47,49..50,52,71..73,125..127,202..204,224,228,
                     255..258)
                     /site_type="other"
                     /note="NAD(P) binding site [chemical binding]"
                     /db_xref="CDD:187668"
     Site            order(147,204,224,228)
                     /site_type="active"
                     /db_xref="CDD:187668"
     CDS             1..346
                     /gene="DHRS12"
                     /gene_synonym="SDR40C1"
                     /coded_by="XM_047430619.1:55..1095"
                     /db_xref="GeneID:79758"
                     /db_xref="HGNC:HGNC:25832"
                     /db_xref="MIM:616163"
ORIGIN      
        1 mslyrsvvwf akglreytks gyesackdfv phdlevqipg rvflvtggns gigkatalei
       61 akrggtvhlv crdqapaeda rgeiiresgn qniflhivdl sdpkqiwkfv enfkqehklh
      121 vlinnagcmv nkreltedgl eknfaantlg vyilttglip vlekehdprv qkglgscssv
      181 qglgmrsvsw siqitvssgg mlvqklntnd lqsertpfdg tmvyaqnkvs erqqvvlter
      241 waqghpaihf ssmhpgwadt pdrneqelrk vvgeaqtasp lprfleimmh egkcqpqghs
      301 sndleacwss gggeqnslpd wphqlhdlrq ltwalcssfl lykqgn
//
LOCUS       XP_047286576             345 aa            linear   PRI 05-AUG-2025
DEFINITION  dehydrogenase/reductase SDR family member 12 isoform X2 [Homo
            sapiens].
ACCESSION   XP_047286576
VERSION     XP_047286576.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430620.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..345
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..345
                     /product="dehydrogenase/reductase SDR family member 12
                     isoform X2"
                     /calculated_mol_wt=38288
     Region          40..>260
                     /region_name="Rossmann-fold NAD(P)(+)-binding proteins"
                     /note="A large family of proteins that share a
                     Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The
                     NADB domain is found in numerous dehydrogenases of
                     metabolic pathways such as glycolysis, and many other
                     redox enzymes. NAD binding involves numerous...; cl21454"
                     /db_xref="CDD:473865"
     Site            order(47,49..50,52,71..73,125..127,201..203,223,227,
                     254..257)
                     /site_type="other"
                     /note="NAD(P) binding site [chemical binding]"
                     /db_xref="CDD:187535"
     Site            order(147,203,223,227)
                     /site_type="active"
                     /db_xref="CDD:187535"
     CDS             1..345
                     /gene="DHRS12"
                     /gene_synonym="SDR40C1"
                     /coded_by="XM_047430620.1:55..1092"
                     /db_xref="GeneID:79758"
                     /db_xref="HGNC:HGNC:25832"
                     /db_xref="MIM:616163"
ORIGIN      
        1 mslyrsvvwf akglreytks gyesackdfv phdlevqipg rvflvtggns gigkatalei
       61 akrggtvhlv crdqapaeda rgeiiresgn qniflhivdl sdpkqiwkfv enfkqehklh
      121 vlinnagcmv nkreltedgl eknfaantlg vyilttglip vlekehdprv kglgscssvq
      181 glgmrsvsws iqitvssggm lvqklntndl qsertpfdgt mvyaqnkvse rqqvvlterw
      241 aqghpaihfs smhpgwadtp drneqelrkv vgeaqtaspl prfleimmhe gkcqpqghss
      301 ndleacwssg ggeqnslpdw phqlhdlrql twalcssfll ykqgn
//
LOCUS       XP_047286577             343 aa            linear   PRI 05-AUG-2025
DEFINITION  dehydrogenase/reductase SDR family member 12 isoform X3 [Homo
            sapiens].
ACCESSION   XP_047286577
VERSION     XP_047286577.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430621.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..343
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..343
                     /product="dehydrogenase/reductase SDR family member 12
                     isoform X3"
                     /calculated_mol_wt=37708
     Region          40..319
                     /region_name="DHRS-12_like_SDR_c-like"
                     /note="human dehydrogenase/reductase SDR family member
                     (DHRS)-12/FLJ13639-like, classical (c)-like SDRs; cd09808"
                     /db_xref="CDD:187668"
     Site            order(47,49..52,71..73,98..100,125..127,146,202..204,224,
                     228,255..258,260..261)
                     /site_type="other"
                     /note="putative NAD(P) binding site [chemical binding]"
                     /db_xref="CDD:187668"
     Site            order(147,204,224,228)
                     /site_type="active"
                     /db_xref="CDD:187668"
     CDS             1..343
                     /gene="DHRS12"
                     /gene_synonym="SDR40C1"
                     /coded_by="XM_047430621.1:55..1086"
                     /db_xref="GeneID:79758"
                     /db_xref="HGNC:HGNC:25832"
                     /db_xref="MIM:616163"
ORIGIN      
        1 mslyrsvvwf akglreytks gyesackdfv phdlevqipg rvflvtggns gigkatalei
       61 akrggtvhlv crdqapaeda rgeiiresgn qniflhivdl sdpkqiwkfv enfkqehklh
      121 vlinnagcmv nkreltedgl eknfaantlg vyilttglip vlekehdprv qkglgscssv
      181 qglgmrsvsw siqitvssgg mlvqklntnd lqsertpfdg tmvyaqnkvs erqqvvlter
      241 waqghpaihf ssmhpgwadt pgvrqampgf harfgdrlrs eaqgadtmlw lalssaaaaq
      301 psgrffqdrk pvsthlplat assspaeeek lieileqlaq tfk
//
LOCUS       XP_047286578             343 aa            linear   PRI 05-AUG-2025
DEFINITION  dehydrogenase/reductase SDR family member 12 isoform X4 [Homo
            sapiens].
ACCESSION   XP_047286578
VERSION     XP_047286578.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430622.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..343
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..343
                     /product="dehydrogenase/reductase SDR family member 12
                     isoform X4"
                     /calculated_mol_wt=38100
     Region          40..>258
                     /region_name="Rossmann-fold NAD(P)(+)-binding proteins"
                     /note="A large family of proteins that share a
                     Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The
                     NADB domain is found in numerous dehydrogenases of
                     metabolic pathways such as glycolysis, and many other
                     redox enzymes. NAD binding involves numerous...; cl21454"
                     /db_xref="CDD:473865"
     Site            order(47,49..50,52,71..73,125..127,202..204,224,228,
                     252..255)
                     /site_type="other"
                     /note="NAD(P) binding site [chemical binding]"
                     /db_xref="CDD:187535"
     Site            order(147,204,224,228)
                     /site_type="active"
                     /db_xref="CDD:187535"
     CDS             1..343
                     /gene="DHRS12"
                     /gene_synonym="SDR40C1"
                     /coded_by="XM_047430622.1:55..1086"
                     /db_xref="GeneID:79758"
                     /db_xref="HGNC:HGNC:25832"
                     /db_xref="MIM:616163"
ORIGIN      
        1 mslyrsvvwf akglreytks gyesackdfv phdlevqipg rvflvtggns gigkatalei
       61 akrggtvhlv crdqapaeda rgeiiresgn qniflhivdl sdpkqiwkfv enfkqehklh
      121 vlinnagcmv nkreltedgl eknfaantlg vyilttglip vlekehdprv qkglgscssv
      181 qglgmrsvsw siqitvssgg mlvqklntnd lqsertpfdg tmvyaqnkrq qvvlterwaq
      241 ghpaihfssm hpgwadtpdr neqelrkvvg eaqtasplpr fleimmhegk cqpqghssnd
      301 leacwssggg eqnslpdwph qlhdlrqltw alcssfllyk qgn
//
LOCUS       XP_047286579             342 aa            linear   PRI 05-AUG-2025
DEFINITION  dehydrogenase/reductase SDR family member 12 isoform X5 [Homo
            sapiens].
ACCESSION   XP_047286579
VERSION     XP_047286579.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430623.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..342
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..342
                     /product="dehydrogenase/reductase SDR family member 12
                     isoform X5"
                     /calculated_mol_wt=37972
     Region          40..>257
                     /region_name="Rossmann-fold NAD(P)(+)-binding proteins"
                     /note="A large family of proteins that share a
                     Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The
                     NADB domain is found in numerous dehydrogenases of
                     metabolic pathways such as glycolysis, and many other
                     redox enzymes. NAD binding involves numerous...; cl21454"
                     /db_xref="CDD:473865"
     Site            order(47,49..50,52,71..73,125..127,201..203,223,227,
                     251..254)
                     /site_type="other"
                     /note="NAD(P) binding site [chemical binding]"
                     /db_xref="CDD:187535"
     Site            order(147,203,223,227)
                     /site_type="active"
                     /db_xref="CDD:187535"
     CDS             1..342
                     /gene="DHRS12"
                     /gene_synonym="SDR40C1"
                     /coded_by="XM_047430623.1:55..1083"
                     /db_xref="GeneID:79758"
                     /db_xref="HGNC:HGNC:25832"
                     /db_xref="MIM:616163"
ORIGIN      
        1 mslyrsvvwf akglreytks gyesackdfv phdlevqipg rvflvtggns gigkatalei
       61 akrggtvhlv crdqapaeda rgeiiresgn qniflhivdl sdpkqiwkfv enfkqehklh
      121 vlinnagcmv nkreltedgl eknfaantlg vyilttglip vlekehdprv kglgscssvq
      181 glgmrsvsws iqitvssggm lvqklntndl qsertpfdgt mvyaqnkrqq vvlterwaqg
      241 hpaihfssmh pgwadtpdrn eqelrkvvge aqtasplprf leimmhegkc qpqghssndl
      301 eacwssggge qnslpdwphq lhdlrqltwa lcssfllykq gn
//
LOCUS       XP_047286580             340 aa            linear   PRI 05-AUG-2025
DEFINITION  dehydrogenase/reductase SDR family member 12 isoform X6 [Homo
            sapiens].
ACCESSION   XP_047286580
VERSION     XP_047286580.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430624.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..340
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..340
                     /product="dehydrogenase/reductase SDR family member 12
                     isoform X6"
                     /calculated_mol_wt=37393
     Region          40..316
                     /region_name="DHRS-12_like_SDR_c-like"
                     /note="human dehydrogenase/reductase SDR family member
                     (DHRS)-12/FLJ13639-like, classical (c)-like SDRs; cd09808"
                     /db_xref="CDD:187668"
     Site            order(47,49..52,71..73,98..100,125..127,146,202..204,224,
                     228,252..255,257..258)
                     /site_type="other"
                     /note="putative NAD(P) binding site [chemical binding]"
                     /db_xref="CDD:187668"
     Site            order(147,204,224,228)
                     /site_type="active"
                     /db_xref="CDD:187668"
     CDS             1..340
                     /gene="DHRS12"
                     /gene_synonym="SDR40C1"
                     /coded_by="XM_047430624.1:55..1077"
                     /db_xref="GeneID:79758"
                     /db_xref="HGNC:HGNC:25832"
                     /db_xref="MIM:616163"
ORIGIN      
        1 mslyrsvvwf akglreytks gyesackdfv phdlevqipg rvflvtggns gigkatalei
       61 akrggtvhlv crdqapaeda rgeiiresgn qniflhivdl sdpkqiwkfv enfkqehklh
      121 vlinnagcmv nkreltedgl eknfaantlg vyilttglip vlekehdprv qkglgscssv
      181 qglgmrsvsw siqitvssgg mlvqklntnd lqsertpfdg tmvyaqnkrq qvvlterwaq
      241 ghpaihfssm hpgwadtpgv rqampgfhar fgdrlrseaq gadtmlwlal ssaaaaqpsg
      301 rffqdrkpvs thlplatass spaeeeklie ileqlaqtfk
//
LOCUS       XP_047286581             323 aa            linear   PRI 05-AUG-2025
DEFINITION  dehydrogenase/reductase SDR family member 12 isoform X7 [Homo
            sapiens].
ACCESSION   XP_047286581
VERSION     XP_047286581.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430625.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..323
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..323
                     /product="dehydrogenase/reductase SDR family member 12
                     isoform X7"
                     /calculated_mol_wt=36038
     Region          40..>238
                     /region_name="Rossmann-fold NAD(P)(+)-binding proteins"
                     /note="A large family of proteins that share a
                     Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The
                     NADB domain is found in numerous dehydrogenases of
                     metabolic pathways such as glycolysis, and many other
                     redox enzymes. NAD binding involves numerous...; cl21454"
                     /db_xref="CDD:473865"
     Site            order(47,49..50,52,71..73,125..127,179..181,201,205,
                     232..235)
                     /site_type="other"
                     /note="NAD(P) binding site [chemical binding]"
                     /db_xref="CDD:187668"
     Site            order(147,181,201,205)
                     /site_type="active"
                     /db_xref="CDD:187668"
     CDS             1..323
                     /gene="DHRS12"
                     /gene_synonym="SDR40C1"
                     /coded_by="XM_047430625.1:55..1026"
                     /db_xref="GeneID:79758"
                     /db_xref="HGNC:HGNC:25832"
                     /db_xref="MIM:616163"
ORIGIN      
        1 mslyrsvvwf akglreytks gyesackdfv phdlevqipg rvflvtggns gigkatalei
       61 akrggtvhlv crdqapaeda rgeiiresgn qniflhivdl sdpkqiwkfv enfkqehklh
      121 vlinnagcmv nkreltedgl eknfaantlg vyilttglip vlekehdprv itvssggmlv
      181 qklntndlqs ertpfdgtmv yaqnkvserq qvvlterwaq ghpaihfssm hpgwadtpdr
      241 neqelrkvvg eaqtasplpr fleimmhegk cqpqghssnd leacwssggg eqnslpdwph
      301 qlhdlrqltw alcssfllyk qgn
//
LOCUS       XP_047286582             297 aa            linear   PRI 05-AUG-2025
DEFINITION  dehydrogenase/reductase SDR family member 12 isoform X8 [Homo
            sapiens].
ACCESSION   XP_047286582
VERSION     XP_047286582.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430626.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..297
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..297
                     /product="dehydrogenase/reductase SDR family member 12
                     isoform X8"
                     /calculated_mol_wt=33412
     Region          33..>212
                     /region_name="Rossmann-fold NAD(P)(+)-binding proteins"
                     /note="A large family of proteins that share a
                     Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The
                     NADB domain is found in numerous dehydrogenases of
                     metabolic pathways such as glycolysis, and many other
                     redox enzymes. NAD binding involves numerous...; cl21454"
                     /db_xref="CDD:473865"
     Site            order(98,155,175,179)
                     /site_type="active"
                     /db_xref="CDD:187668"
     CDS             1..297
                     /gene="DHRS12"
                     /gene_synonym="SDR40C1"
                     /coded_by="XM_047430626.1:119..1012"
                     /db_xref="GeneID:79758"
                     /db_xref="HGNC:HGNC:25832"
                     /db_xref="MIM:616163"
ORIGIN      
        1 mnlhvktlsl mtwrsrflee sfwsleetaa lakqlplksp seniflhivd lsdpkqiwkf
       61 venfkqehkl hvlinnagcm vnkreltedg leknfaantl gvyilttgli pvlekehdpr
      121 vqkglgscss vqglgmrsvs wsiqitvssg gmlvqklntn dlqsertpfd gtmvyaqnkv
      181 serqqvvlte rwaqghpaih fssmhpgwad tpdrneqelr kvvgeaqtas plprfleimm
      241 hegkcqpqgh ssndleacws sgggeqnslp dwphqlhdlr qltwalcssf llykqgn
//
LOCUS       XP_047286583             293 aa            linear   PRI 05-AUG-2025
DEFINITION  dehydrogenase/reductase SDR family member 12 isoform X9 [Homo
            sapiens].
ACCESSION   XP_047286583
VERSION     XP_047286583.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430627.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..293
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..293
                     /product="dehydrogenase/reductase SDR family member 12
                     isoform X9"
                     /calculated_mol_wt=32969
     Region          33..>208
                     /region_name="Rossmann-fold NAD(P)(+)-binding proteins"
                     /note="A large family of proteins that share a
                     Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The
                     NADB domain is found in numerous dehydrogenases of
                     metabolic pathways such as glycolysis, and many other
                     redox enzymes. NAD binding involves numerous...; cl21454"
                     /db_xref="CDD:473865"
     Site            order(98,154,174,178)
                     /site_type="active"
                     /db_xref="CDD:187535"
     CDS             1..293
                     /gene="DHRS12"
                     /gene_synonym="SDR40C1"
                     /coded_by="XM_047430627.1:119..1000"
                     /db_xref="GeneID:79758"
                     /db_xref="HGNC:HGNC:25832"
                     /db_xref="MIM:616163"
ORIGIN      
        1 mnlhvktlsl mtwrsrflee sfwsleetaa lakqlplksp seniflhivd lsdpkqiwkf
       61 venfkqehkl hvlinnagcm vnkreltedg leknfaantl gvyilttgli pvlekehdpr
      121 vkglgscssv qglgmrsvsw siqitvssgg mlvqklntnd lqsertpfdg tmvyaqnkrq
      181 qvvlterwaq ghpaihfssm hpgwadtpdr neqelrkvvg eaqtasplpr fleimmhegk
      241 cqpqghssnd leacwssggg eqnslpdwph qlhdlrqltw alcssfllyk qgn
//
LOCUS       XP_047286584             291 aa            linear   PRI 05-AUG-2025
DEFINITION  dehydrogenase/reductase SDR family member 12 isoform X10 [Homo
            sapiens].
ACCESSION   XP_047286584
VERSION     XP_047286584.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430628.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..291
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..291
                     /product="dehydrogenase/reductase SDR family member 12
                     isoform X10"
                     /calculated_mol_wt=32389
     Region          33..267
                     /region_name="Rossmann-fold NAD(P)(+)-binding proteins"
                     /note="A large family of proteins that share a
                     Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The
                     NADB domain is found in numerous dehydrogenases of
                     metabolic pathways such as glycolysis, and many other
                     redox enzymes. NAD binding involves numerous...; cl21454"
                     /db_xref="CDD:473865"
     Site            order(98,155,175,179)
                     /site_type="active"
                     /db_xref="CDD:187535"
     CDS             1..291
                     /gene="DHRS12"
                     /gene_synonym="SDR40C1"
                     /coded_by="XM_047430628.1:119..994"
                     /db_xref="GeneID:79758"
                     /db_xref="HGNC:HGNC:25832"
                     /db_xref="MIM:616163"
ORIGIN      
        1 mnlhvktlsl mtwrsrflee sfwsleetaa lakqlplksp seniflhivd lsdpkqiwkf
       61 venfkqehkl hvlinnagcm vnkreltedg leknfaantl gvyilttgli pvlekehdpr
      121 vqkglgscss vqglgmrsvs wsiqitvssg gmlvqklntn dlqsertpfd gtmvyaqnkr
      181 qqvvlterwa qghpaihfss mhpgwadtpg vrqampgfha rfgdrlrsea qgadtmlwla
      241 lssaaaaqps grffqdrkpv sthlplatas sspaeeekli eileqlaqtf k
//
LOCUS       XP_047286585             291 aa            linear   PRI 05-AUG-2025
DEFINITION  dehydrogenase/reductase SDR family member 12 isoform X11 [Homo
            sapiens].
ACCESSION   XP_047286585
VERSION     XP_047286585.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430629.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..291
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..291
                     /product="dehydrogenase/reductase SDR family member 12
                     isoform X11"
                     /calculated_mol_wt=32137
     Region          40..>266
                     /region_name="Rossmann-fold NAD(P)(+)-binding proteins"
                     /note="A large family of proteins that share a
                     Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The
                     NADB domain is found in numerous dehydrogenases of
                     metabolic pathways such as glycolysis, and many other
                     redox enzymes. NAD binding involves numerous...; cl21454"
                     /db_xref="CDD:473865"
     Site            order(47,49..50,52,71..73,125..127,202..204,224,228,
                     255..258)
                     /site_type="other"
                     /note="NAD(P) binding site [chemical binding]"
                     /db_xref="CDD:187535"
     Site            order(147,204,224,228)
                     /site_type="active"
                     /db_xref="CDD:187535"
     CDS             1..291
                     /gene="DHRS12"
                     /gene_synonym="SDR40C1"
                     /coded_by="XM_047430629.1:55..930"
                     /db_xref="GeneID:79758"
                     /db_xref="HGNC:HGNC:25832"
                     /db_xref="MIM:616163"
ORIGIN      
        1 mslyrsvvwf akglreytks gyesackdfv phdlevqipg rvflvtggns gigkatalei
       61 akrggtvhlv crdqapaeda rgeiiresgn qniflhivdl sdpkqiwkfv enfkqehklh
      121 vlinnagcmv nkreltedgl eknfaantlg vyilttglip vlekehdprv qkglgscssv
      181 qglgmrsvsw siqitvssgg mlvqklntnd lqsertpfdg tmvyaqnkvs erqqvvlter
      241 waqghpaihf ssmhpgwadt pgyhkslggk gellllavdy ilnqqkleqp e
//
LOCUS       XP_047286586             274 aa            linear   PRI 05-AUG-2025
DEFINITION  dehydrogenase/reductase SDR family member 12 isoform X12 [Homo
            sapiens].
ACCESSION   XP_047286586
VERSION     XP_047286586.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430630.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..274
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..274
                     /product="dehydrogenase/reductase SDR family member 12
                     isoform X12"
                     /calculated_mol_wt=31034
     Region          33..>189
                     /region_name="Rossmann-fold NAD(P)(+)-binding proteins"
                     /note="A large family of proteins that share a
                     Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The
                     NADB domain is found in numerous dehydrogenases of
                     metabolic pathways such as glycolysis, and many other
                     redox enzymes. NAD binding involves numerous...; cl21454"
                     /db_xref="CDD:473865"
     Site            order(98,132,152,156)
                     /site_type="active"
                     /db_xref="CDD:187668"
     CDS             1..274
                     /gene="DHRS12"
                     /gene_synonym="SDR40C1"
                     /coded_by="XM_047430630.1:119..943"
                     /db_xref="GeneID:79758"
                     /db_xref="HGNC:HGNC:25832"
                     /db_xref="MIM:616163"
ORIGIN      
        1 mnlhvktlsl mtwrsrflee sfwsleetaa lakqlplksp seniflhivd lsdpkqiwkf
       61 venfkqehkl hvlinnagcm vnkreltedg leknfaantl gvyilttgli pvlekehdpr
      121 vitvssggml vqklntndlq sertpfdgtm vyaqnkvser qqvvlterwa qghpaihfss
      181 mhpgwadtpd rneqelrkvv geaqtasplp rfleimmheg kcqpqghssn dleacwssgg
      241 geqnslpdwp hqlhdlrqlt walcssflly kqgn
//
LOCUS       XP_047286587             271 aa            linear   PRI 05-AUG-2025
DEFINITION  dehydrogenase/reductase SDR family member 12 isoform X13 [Homo
            sapiens].
ACCESSION   XP_047286587
VERSION     XP_047286587.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430631.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..271
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..271
                     /product="dehydrogenase/reductase SDR family member 12
                     isoform X13"
                     /calculated_mol_wt=30327
     Region          33..247
                     /region_name="Rossmann-fold NAD(P)(+)-binding proteins"
                     /note="A large family of proteins that share a
                     Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The
                     NADB domain is found in numerous dehydrogenases of
                     metabolic pathways such as glycolysis, and many other
                     redox enzymes. NAD binding involves numerous...; cl21454"
                     /db_xref="CDD:473865"
     Site            order(98,132,152,156)
                     /site_type="active"
                     /db_xref="CDD:187535"
     CDS             1..271
                     /gene="DHRS12"
                     /gene_synonym="SDR40C1"
                     /coded_by="XM_047430631.1:119..934"
                     /db_xref="GeneID:79758"
                     /db_xref="HGNC:HGNC:25832"
                     /db_xref="MIM:616163"
ORIGIN      
        1 mnlhvktlsl mtwrsrflee sfwsleetaa lakqlplksp seniflhivd lsdpkqiwkf
       61 venfkqehkl hvlinnagcm vnkreltedg leknfaantl gvyilttgli pvlekehdpr
      121 vitvssggml vqklntndlq sertpfdgtm vyaqnkvser qqvvlterwa qghpaihfss
      181 mhpgwadtpg vrqampgfha rfgdrlrsea qgadtmlwla lssaaaaqps grffqdrkpv
      241 sthlplatas sspaeeekli eileqlaqtf k
//
LOCUS       XP_047286588             265 aa            linear   PRI 05-AUG-2025
DEFINITION  dehydrogenase/reductase SDR family member 12 isoform X14 [Homo
            sapiens].
ACCESSION   XP_047286588
VERSION     XP_047286588.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430632.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..265
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..265
                     /product="dehydrogenase/reductase SDR family member 12
                     isoform X14"
                     /calculated_mol_wt=29444
     Region          40..>240
                     /region_name="Rossmann-fold NAD(P)(+)-binding proteins"
                     /note="A large family of proteins that share a
                     Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The
                     NADB domain is found in numerous dehydrogenases of
                     metabolic pathways such as glycolysis, and many other
                     redox enzymes. NAD binding involves numerous...; cl21454"
                     /db_xref="CDD:473865"
     Site            order(47,49..50,52,71..73,125..127,179..181,201,205,
                     229..232)
                     /site_type="other"
                     /note="NAD(P) binding site [chemical binding]"
                     /db_xref="CDD:187535"
     Site            order(147,181,201,205)
                     /site_type="active"
                     /db_xref="CDD:187535"
     CDS             1..265
                     /gene="DHRS12"
                     /gene_synonym="SDR40C1"
                     /coded_by="XM_047430632.1:55..852"
                     /db_xref="GeneID:79758"
                     /db_xref="HGNC:HGNC:25832"
                     /db_xref="MIM:616163"
ORIGIN      
        1 mslyrsvvwf akglreytks gyesackdfv phdlevqipg rvflvtggns gigkatalei
       61 akrggtvhlv crdqapaeda rgeiiresgn qniflhivdl sdpkqiwkfv enfkqehklh
      121 vlinnagcmv nkreltedgl eknfaantlg vyilttglip vlekehdprv itvssggmlv
      181 qklntndlqs ertpfdgtmv yaqnkrqqvv lterwaqghp aihfssmhpg wadtpgyhks
      241 lggkgellll avdyilnqqk leqpe
//
LOCUS       XP_047286589             255 aa            linear   PRI 05-AUG-2025
DEFINITION  dehydrogenase/reductase SDR family member 12 isoform X15 [Homo
            sapiens].
ACCESSION   XP_047286589
VERSION     XP_047286589.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430633.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..255
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..255
                     /product="dehydrogenase/reductase SDR family member 12
                     isoform X15"
                     /calculated_mol_wt=27769
     Region          40..>233
                     /region_name="Rossmann-fold NAD(P)(+)-binding proteins"
                     /note="A large family of proteins that share a
                     Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The
                     NADB domain is found in numerous dehydrogenases of
                     metabolic pathways such as glycolysis, and many other
                     redox enzymes. NAD binding involves numerous...; cl21454"
                     /db_xref="CDD:473865"
     Site            order(147,204,224,228)
                     /site_type="active"
                     /db_xref="CDD:187535"
     CDS             1..255
                     /gene="DHRS12"
                     /gene_synonym="SDR40C1"
                     /coded_by="XM_047430633.1:55..822"
                     /db_xref="GeneID:79758"
                     /db_xref="HGNC:HGNC:25832"
                     /db_xref="MIM:616163"
ORIGIN      
        1 mslyrsvvwf akglreytks gyesackdfv phdlevqipg rvflvtggns gigkatalei
       61 akrggtvhlv crdqapaeda rgeiiresgn qniflhivdl sdpkqiwkfv enfkqehklh
      121 vlinnagcmv nkreltedgl eknfaantlg vyilttglip vlekehdprv qkglgscssv
      181 qglgmrsvsw siqitvssgg mlvqklntnd lqsertpfdg tmvyaqnkga hivckaastl
      241 rlpcrccvps eggpv
//
LOCUS       XP_047286590             248 aa            linear   PRI 05-AUG-2025
DEFINITION  dehydrogenase/reductase SDR family member 12 isoform X16 [Homo
            sapiens].
ACCESSION   XP_047286590
VERSION     XP_047286590.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430634.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..248
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..248
                     /product="dehydrogenase/reductase SDR family member 12
                     isoform X16"
                     /calculated_mol_wt=27405
     Region          40..>228
                     /region_name="Rossmann-fold NAD(P)(+)-binding proteins"
                     /note="A large family of proteins that share a
                     Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The
                     NADB domain is found in numerous dehydrogenases of
                     metabolic pathways such as glycolysis, and many other
                     redox enzymes. NAD binding involves numerous...; cl21454"
                     /db_xref="CDD:473865"
     Site            order(147,204,224,228)
                     /site_type="active"
                     /db_xref="CDD:187535"
     CDS             1..248
                     /gene="DHRS12"
                     /gene_synonym="SDR40C1"
                     /coded_by="XM_047430634.1:55..801"
                     /db_xref="GeneID:79758"
                     /db_xref="HGNC:HGNC:25832"
                     /db_xref="MIM:616163"
ORIGIN      
        1 mslyrsvvwf akglreytks gyesackdfv phdlevqipg rvflvtggns gigkatalei
       61 akrggtvhlv crdqapaeda rgeiiresgn qniflhivdl sdpkqiwkfv enfkqehklh
      121 vlinnagcmv nkreltedgl eknfaantlg vyilttglip vlekehdprv qkglgscssv
      181 qglgmrsvsw siqitvssgg mlvqklntnd lqsertpfdg tmvyaqnkdt tnllvakesf
      241 yclpwtif
//
LOCUS       XP_047286591             234 aa            linear   PRI 05-AUG-2025
DEFINITION  dehydrogenase/reductase SDR family member 12 isoform X17 [Homo
            sapiens].
ACCESSION   XP_047286591
VERSION     XP_047286591.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430635.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..234
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..234
                     /product="dehydrogenase/reductase SDR family member 12
                     isoform X17"
                     /calculated_mol_wt=25681
     Region          40..>228
                     /region_name="Rossmann-fold NAD(P)(+)-binding proteins"
                     /note="A large family of proteins that share a
                     Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The
                     NADB domain is found in numerous dehydrogenases of
                     metabolic pathways such as glycolysis, and many other
                     redox enzymes. NAD binding involves numerous...; cl21454"
                     /db_xref="CDD:473865"
     Site            order(147,204,224,228)
                     /site_type="active"
                     /db_xref="CDD:187535"
     CDS             1..234
                     /gene="DHRS12"
                     /gene_synonym="SDR40C1"
                     /coded_by="XM_047430635.1:55..759"
                     /db_xref="GeneID:79758"
                     /db_xref="HGNC:HGNC:25832"
                     /db_xref="MIM:616163"
ORIGIN      
        1 mslyrsvvwf akglreytks gyesackdfv phdlevqipg rvflvtggns gigkatalei
       61 akrggtvhlv crdqapaeda rgeiiresgn qniflhivdl sdpkqiwkfv enfkqehklh
      121 vlinnagcmv nkreltedgl eknfaantlg vyilttglip vlekehdprv qkglgscssv
      181 qglgmrsvsw siqitvssgg mlvqklntnd lqsertpfdg tmvyaqnktg msrs
//
LOCUS       XP_047286592             232 aa            linear   PRI 05-AUG-2025
DEFINITION  dehydrogenase/reductase SDR family member 12 isoform X18 [Homo
            sapiens].
ACCESSION   XP_047286592
VERSION     XP_047286592.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430636.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..232
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..232
                     /product="dehydrogenase/reductase SDR family member 12
                     isoform X18"
                     /calculated_mol_wt=25391
     Region          40..>210
                     /region_name="Rossmann-fold NAD(P)(+)-binding proteins"
                     /note="A large family of proteins that share a
                     Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The
                     NADB domain is found in numerous dehydrogenases of
                     metabolic pathways such as glycolysis, and many other
                     redox enzymes. NAD binding involves numerous...; cl21454"
                     /db_xref="CDD:473865"
     Site            order(147,181,201,205)
                     /site_type="active"
                     /db_xref="CDD:187535"
     CDS             1..232
                     /gene="DHRS12"
                     /gene_synonym="SDR40C1"
                     /coded_by="XM_047430636.1:55..753"
                     /db_xref="GeneID:79758"
                     /db_xref="HGNC:HGNC:25832"
                     /db_xref="MIM:616163"
ORIGIN      
        1 mslyrsvvwf akglreytks gyesackdfv phdlevqipg rvflvtggns gigkatalei
       61 akrggtvhlv crdqapaeda rgeiiresgn qniflhivdl sdpkqiwkfv enfkqehklh
      121 vlinnagcmv nkreltedgl eknfaantlg vyilttglip vlekehdprv itvssggmlv
      181 qklntndlqs ertpfdgtmv yaqnkgahiv ckaastlrlp crccvpsegg pv
//
LOCUS       XP_047286593             225 aa            linear   PRI 05-AUG-2025
DEFINITION  dehydrogenase/reductase SDR family member 12 isoform X19 [Homo
            sapiens].
ACCESSION   XP_047286593
VERSION     XP_047286593.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430637.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..225
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..225
                     /product="dehydrogenase/reductase SDR family member 12
                     isoform X19"
                     /calculated_mol_wt=25028
     Region          40..>205
                     /region_name="Rossmann-fold NAD(P)(+)-binding proteins"
                     /note="A large family of proteins that share a
                     Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The
                     NADB domain is found in numerous dehydrogenases of
                     metabolic pathways such as glycolysis, and many other
                     redox enzymes. NAD binding involves numerous...; cl21454"
                     /db_xref="CDD:473865"
     Site            order(147,181,201,205)
                     /site_type="active"
                     /db_xref="CDD:187668"
     CDS             1..225
                     /gene="DHRS12"
                     /gene_synonym="SDR40C1"
                     /coded_by="XM_047430637.1:55..732"
                     /db_xref="GeneID:79758"
                     /db_xref="HGNC:HGNC:25832"
                     /db_xref="MIM:616163"
ORIGIN      
        1 mslyrsvvwf akglreytks gyesackdfv phdlevqipg rvflvtggns gigkatalei
       61 akrggtvhlv crdqapaeda rgeiiresgn qniflhivdl sdpkqiwkfv enfkqehklh
      121 vlinnagcmv nkreltedgl eknfaantlg vyilttglip vlekehdprv itvssggmlv
      181 qklntndlqs ertpfdgtmv yaqnkdttnl lvakesfycl pwtif
//
LOCUS       XP_047286594             216 aa            linear   PRI 05-AUG-2025
DEFINITION  dehydrogenase/reductase SDR family member 12 isoform X20 [Homo
            sapiens].
ACCESSION   XP_047286594
VERSION     XP_047286594.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430638.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..216
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..216
                     /product="dehydrogenase/reductase SDR family member 12
                     isoform X20"
                     /calculated_mol_wt=24440
     Region          33..>191
                     /region_name="Rossmann-fold NAD(P)(+)-binding proteins"
                     /note="A large family of proteins that share a
                     Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The
                     NADB domain is found in numerous dehydrogenases of
                     metabolic pathways such as glycolysis, and many other
                     redox enzymes. NAD binding involves numerous...; cl21454"
                     /db_xref="CDD:473865"
     Site            order(98,132,152,156)
                     /site_type="active"
                     /db_xref="CDD:187535"
     CDS             1..216
                     /gene="DHRS12"
                     /gene_synonym="SDR40C1"
                     /coded_by="XM_047430638.1:119..769"
                     /db_xref="GeneID:79758"
                     /db_xref="HGNC:HGNC:25832"
                     /db_xref="MIM:616163"
ORIGIN      
        1 mnlhvktlsl mtwrsrflee sfwsleetaa lakqlplksp seniflhivd lsdpkqiwkf
       61 venfkqehkl hvlinnagcm vnkreltedg leknfaantl gvyilttgli pvlekehdpr
      121 vitvssggml vqklntndlq sertpfdgtm vyaqnkrqqv vlterwaqgh paihfssmhp
      181 gwadtpgyhk slggkgelll lavdyilnqq kleqpe
//
LOCUS       XP_047286595             211 aa            linear   PRI 05-AUG-2025
DEFINITION  dehydrogenase/reductase SDR family member 12 isoform X21 [Homo
            sapiens].
ACCESSION   XP_047286595
VERSION     XP_047286595.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430639.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..211
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..211
                     /product="dehydrogenase/reductase SDR family member 12
                     isoform X21"
                     /calculated_mol_wt=23304
     Region          40..>205
                     /region_name="Rossmann-fold NAD(P)(+)-binding proteins"
                     /note="A large family of proteins that share a
                     Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The
                     NADB domain is found in numerous dehydrogenases of
                     metabolic pathways such as glycolysis, and many other
                     redox enzymes. NAD binding involves numerous...; cl21454"
                     /db_xref="CDD:473865"
     Site            order(147,181,201,205)
                     /site_type="active"
                     /db_xref="CDD:187668"
     CDS             1..211
                     /gene="DHRS12"
                     /gene_synonym="SDR40C1"
                     /coded_by="XM_047430639.1:55..690"
                     /db_xref="GeneID:79758"
                     /db_xref="HGNC:HGNC:25832"
                     /db_xref="MIM:616163"
ORIGIN      
        1 mslyrsvvwf akglreytks gyesackdfv phdlevqipg rvflvtggns gigkatalei
       61 akrggtvhlv crdqapaeda rgeiiresgn qniflhivdl sdpkqiwkfv enfkqehklh
      121 vlinnagcmv nkreltedgl eknfaantlg vyilttglip vlekehdprv itvssggmlv
      181 qklntndlqs ertpfdgtmv yaqnktgmsr s
//
LOCUS       XP_047286596             206 aa            linear   PRI 05-AUG-2025
DEFINITION  dehydrogenase/reductase SDR family member 12 isoform X22 [Homo
            sapiens].
ACCESSION   XP_047286596
VERSION     XP_047286596.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430640.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..206
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..206
                     /product="dehydrogenase/reductase SDR family member 12
                     isoform X22"
                     /calculated_mol_wt=22765
     Region          33..>184
                     /region_name="Rossmann-fold NAD(P)(+)-binding proteins"
                     /note="A large family of proteins that share a
                     Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The
                     NADB domain is found in numerous dehydrogenases of
                     metabolic pathways such as glycolysis, and many other
                     redox enzymes. NAD binding involves numerous...; cl21454"
                     /db_xref="CDD:473865"
     Site            order(98,155,175,179)
                     /site_type="active"
                     /db_xref="CDD:187535"
     CDS             1..206
                     /gene="DHRS12"
                     /gene_synonym="SDR40C1"
                     /coded_by="XM_047430640.1:119..739"
                     /db_xref="GeneID:79758"
                     /db_xref="HGNC:HGNC:25832"
                     /db_xref="MIM:616163"
ORIGIN      
        1 mnlhvktlsl mtwrsrflee sfwsleetaa lakqlplksp seniflhivd lsdpkqiwkf
       61 venfkqehkl hvlinnagcm vnkreltedg leknfaantl gvyilttgli pvlekehdpr
      121 vqkglgscss vqglgmrsvs wsiqitvssg gmlvqklntn dlqsertpfd gtmvyaqnkg
      181 ahivckaast lrlpcrccvp seggpv
//
LOCUS       XP_047286597             183 aa            linear   PRI 05-AUG-2025
DEFINITION  dehydrogenase/reductase SDR family member 12 isoform X23 [Homo
            sapiens].
ACCESSION   XP_047286597
VERSION     XP_047286597.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430641.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..183
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..183
                     /product="dehydrogenase/reductase SDR family member 12
                     isoform X23"
                     /calculated_mol_wt=20388
     Region          33..>161
                     /region_name="Rossmann-fold NAD(P)(+)-binding proteins"
                     /note="A large family of proteins that share a
                     Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The
                     NADB domain is found in numerous dehydrogenases of
                     metabolic pathways such as glycolysis, and many other
                     redox enzymes. NAD binding involves numerous...; cl21454"
                     /db_xref="CDD:473865"
     Site            order(98,132,152,156)
                     /site_type="active"
                     /db_xref="CDD:187535"
     CDS             1..183
                     /gene="DHRS12"
                     /gene_synonym="SDR40C1"
                     /coded_by="XM_047430641.1:119..670"
                     /db_xref="GeneID:79758"
                     /db_xref="HGNC:HGNC:25832"
                     /db_xref="MIM:616163"
ORIGIN      
        1 mnlhvktlsl mtwrsrflee sfwsleetaa lakqlplksp seniflhivd lsdpkqiwkf
       61 venfkqehkl hvlinnagcm vnkreltedg leknfaantl gvyilttgli pvlekehdpr
      121 vitvssggml vqklntndlq sertpfdgtm vyaqnkgahi vckaastlrl pcrccvpseg
      181 gpv
//
LOCUS       XP_047286598             176 aa            linear   PRI 05-AUG-2025
DEFINITION  dehydrogenase/reductase SDR family member 12 isoform X24 [Homo
            sapiens].
ACCESSION   XP_047286598
VERSION     XP_047286598.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430642.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..176
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..176
                     /product="dehydrogenase/reductase SDR family member 12
                     isoform X24"
                     /calculated_mol_wt=20024
     Region          33..>156
                     /region_name="Rossmann-fold NAD(P)(+)-binding proteins"
                     /note="A large family of proteins that share a
                     Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The
                     NADB domain is found in numerous dehydrogenases of
                     metabolic pathways such as glycolysis, and many other
                     redox enzymes. NAD binding involves numerous...; cl21454"
                     /db_xref="CDD:473865"
     Site            order(98,132,152,156)
                     /site_type="active"
                     /db_xref="CDD:187535"
     CDS             1..176
                     /gene="DHRS12"
                     /gene_synonym="SDR40C1"
                     /coded_by="XM_047430642.1:119..649"
                     /db_xref="GeneID:79758"
                     /db_xref="HGNC:HGNC:25832"
                     /db_xref="MIM:616163"
ORIGIN      
        1 mnlhvktlsl mtwrsrflee sfwsleetaa lakqlplksp seniflhivd lsdpkqiwkf
       61 venfkqehkl hvlinnagcm vnkreltedg leknfaantl gvyilttgli pvlekehdpr
      121 vitvssggml vqklntndlq sertpfdgtm vyaqnkdttn llvakesfyc lpwtif
//
LOCUS       XP_047286599             167 aa            linear   PRI 05-AUG-2025
DEFINITION  dehydrogenase/reductase SDR family member 12 isoform X25 [Homo
            sapiens].
ACCESSION   XP_047286599
VERSION     XP_047286599.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430643.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..167
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..167
                     /product="dehydrogenase/reductase SDR family member 12
                     isoform X25"
                     /calculated_mol_wt=18468
     Region          40..>150
                     /region_name="Rossmann-fold NAD(P)(+)-binding proteins"
                     /note="A large family of proteins that share a
                     Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The
                     NADB domain is found in numerous dehydrogenases of
                     metabolic pathways such as glycolysis, and many other
                     redox enzymes. NAD binding involves numerous...; cl21454"
                     /db_xref="CDD:473865"
     CDS             1..167
                     /gene="DHRS12"
                     /gene_synonym="SDR40C1"
                     /coded_by="XM_047430643.1:55..558"
                     /db_xref="GeneID:79758"
                     /db_xref="HGNC:HGNC:25832"
                     /db_xref="MIM:616163"
ORIGIN      
        1 mslyrsvvwf akglreytks gyesackdfv phdlevqipg rvflvtggns gigkatalei
       61 akrggtvhlv crdqapaeda rgeiiresgn qniflhivdl sdpkqiwkfv enfkqehklh
      121 vlinnagcmv nkreltedgl eknfaantlg sarlfidivl krrassa
//
LOCUS       XP_047286601             162 aa            linear   PRI 05-AUG-2025
DEFINITION  dehydrogenase/reductase SDR family member 12 isoform X26 [Homo
            sapiens].
ACCESSION   XP_047286601
VERSION     XP_047286601.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430645.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..162
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..162
                     /product="dehydrogenase/reductase SDR family member 12
                     isoform X26"
                     /calculated_mol_wt=18300
     Region          33..>156
                     /region_name="Rossmann-fold NAD(P)(+)-binding proteins"
                     /note="A large family of proteins that share a
                     Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The
                     NADB domain is found in numerous dehydrogenases of
                     metabolic pathways such as glycolysis, and many other
                     redox enzymes. NAD binding involves numerous...; cl21454"
                     /db_xref="CDD:473865"
     Site            order(98,132,152,156)
                     /site_type="active"
                     /db_xref="CDD:187535"
     CDS             1..162
                     /gene="DHRS12"
                     /gene_synonym="SDR40C1"
                     /coded_by="XM_047430645.1:119..607"
                     /db_xref="GeneID:79758"
                     /db_xref="HGNC:HGNC:25832"
                     /db_xref="MIM:616163"
ORIGIN      
        1 mnlhvktlsl mtwrsrflee sfwsleetaa lakqlplksp seniflhivd lsdpkqiwkf
       61 venfkqehkl hvlinnagcm vnkreltedg leknfaantl gvyilttgli pvlekehdpr
      121 vitvssggml vqklntndlq sertpfdgtm vyaqnktgms rs
//
LOCUS       XP_047286602             162 aa            linear   PRI 05-AUG-2025
DEFINITION  dehydrogenase/reductase SDR family member 12 isoform X27 [Homo
            sapiens].
ACCESSION   XP_047286602
VERSION     XP_047286602.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430646.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..162
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..162
                     /product="dehydrogenase/reductase SDR family member 12
                     isoform X27"
                     /calculated_mol_wt=18142
     Region          <10..>77
                     /region_name="Rossmann-fold NAD(P)(+)-binding proteins"
                     /note="A large family of proteins that share a
                     Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The
                     NADB domain is found in numerous dehydrogenases of
                     metabolic pathways such as glycolysis, and many other
                     redox enzymes. NAD binding involves numerous...; cl21454"
                     /db_xref="CDD:473865"
     CDS             1..162
                     /gene="DHRS12"
                     /gene_synonym="SDR40C1"
                     /coded_by="XM_047430646.1:197..685"
                     /db_xref="GeneID:79758"
                     /db_xref="HGNC:HGNC:25832"
                     /db_xref="MIM:616163"
ORIGIN      
        1 mrsvswsiqi tvssggmlvq klntndlqse rtpfdgtmvy aqnkvserqq vvlterwaqg
       61 hpaihfssmh pgwadtpdrn eqelrkvvge aqtasplprf leimmhegkc qpqghssndl
      121 eacwssggge qnslpdwphq lhdlrqltwa lcssfllykq gn
//
LOCUS       XP_047286603             162 aa            linear   PRI 05-AUG-2025
DEFINITION  dehydrogenase/reductase SDR family member 12 isoform X27 [Homo
            sapiens].
ACCESSION   XP_047286603
VERSION     XP_047286603.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430647.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..162
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..162
                     /product="dehydrogenase/reductase SDR family member 12
                     isoform X27"
                     /calculated_mol_wt=18142
     Region          <10..>77
                     /region_name="Rossmann-fold NAD(P)(+)-binding proteins"
                     /note="A large family of proteins that share a
                     Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The
                     NADB domain is found in numerous dehydrogenases of
                     metabolic pathways such as glycolysis, and many other
                     redox enzymes. NAD binding involves numerous...; cl21454"
                     /db_xref="CDD:473865"
     CDS             1..162
                     /gene="DHRS12"
                     /gene_synonym="SDR40C1"
                     /coded_by="XM_047430647.1:194..682"
                     /db_xref="GeneID:79758"
                     /db_xref="HGNC:HGNC:25832"
                     /db_xref="MIM:616163"
ORIGIN      
        1 mrsvswsiqi tvssggmlvq klntndlqse rtpfdgtmvy aqnkvserqq vvlterwaqg
       61 hpaihfssmh pgwadtpdrn eqelrkvvge aqtasplprf leimmhegkc qpqghssndl
      121 eacwssggge qnslpdwphq lhdlrqltwa lcssfllykq gn
//
LOCUS       XP_011533541             915 aa            linear   PRI 05-AUG-2025
DEFINITION  proline and serine-rich protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_011533541
VERSION     XP_011533541.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535239.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..915
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..915
                     /product="proline and serine-rich protein 1 isoform X1"
                     /calculated_mol_wt=92682
     Region          29..121
                     /region_name="DUF4476"
                     /note="Domain of unknown function (DUF4476); pfam14771"
                     /db_xref="CDD:434196"
     Region          <146..574
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          <508..910
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..915
                     /gene="PROSER1"
                     /gene_synonym="C13orf23"
                     /coded_by="XM_011535239.4:848..3595"
                     /db_xref="GeneID:80209"
                     /db_xref="HGNC:HGNC:20291"
                     /db_xref="MIM:620773"
ORIGIN      
        1 mdkksfemvl deirkavlte yklkaieyvh gyfsseqvvd llryfswaep qlkamkalqh
       61 kmvavqptev vnilncftfs kdklvalell asniidaqns rpiedlfrvn msekkrckri
      121 leqafkggck aphamisscg tipgnpypkg rpsringifp gtplkkdgee ctnegkgiaa
      181 rilgpskppp stynphkpvp ypippcrpha tiapknedls npskpiqnqt fstpasqlfs
      241 phgsnpstpa atpvptaspv kainhpsasa aatvsgmnll ntvlpvfpgq vssavhtpqp
      301 sipnptvirt pslptapvts ihsttttpvp sifsglvslp gpsatptaat ptpgptprst
      361 lgsseafast sapftslpfs tsssaastsn pnsaslssvf aglplplppt sqglsnptpv
      421 iaggstpsva gplgvnspll salkgfltsn dtnlinssal ssavtsglas lssltlqnsd
      481 ssasapnkcy apsaiptpqr tstpglalfp glpspvanst stpltlpvqs plataasast
      541 svpvscgssa sllrgphpgt sdlhisstpa attlpvmikt eptsptpsaf kgpshsgnps
      601 hgtlglsgtl graytstsvp islsaclnpa lsglsslstp lngsnplssi slpphgsstp
      661 iapvftalps ftsltnnfpl tgnpslnpsv slpgsliats staatstslp hpsstaavls
      721 glsasapvsa apfplnlsta vpslfsvtqg plsssnpsyp gfsvsntpsv tpalpsfpgl
      781 qapstvaavt plpvaataps papvlpgfas afssnfnsal vaqaglssgl qaagssvfpg
      841 llslpgipgf pqnpsqsslq elqhnaaaqs allqqvhsas alesypaqpd gfpsypsapg
      901 tpfslqpsls qsgwq
//
LOCUS       XP_047286608             893 aa            linear   PRI 05-AUG-2025
DEFINITION  proline and serine-rich protein 1 isoform X2 [Homo sapiens].
ACCESSION   XP_047286608
VERSION     XP_047286608.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430652.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..893
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..893
                     /product="proline and serine-rich protein 1 isoform X2"
                     /calculated_mol_wt=90124
     Region          12..99
                     /region_name="DUF4476"
                     /note="Domain of unknown function (DUF4476); pfam14771"
                     /db_xref="CDD:434196"
     Region          <124..552
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          <486..888
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..893
                     /gene="PROSER1"
                     /gene_synonym="C13orf23"
                     /coded_by="XM_047430652.1:848..3529"
                     /db_xref="GeneID:80209"
                     /db_xref="HGNC:HGNC:20291"
                     /db_xref="MIM:620773"
ORIGIN      
        1 mdkksfemvl deirkvvdll ryfswaepql kamkalqhkm vavqptevvn ilncftfskd
       61 klvalellas niidaqnsrp iedlfrvnms ekkrckrile qafkggckap hamisscgti
      121 pgnpypkgrp sringifpgt plkkdgeect negkgiaari lgpskpppst ynphkpvpyp
      181 ippcrphati apknedlsnp skpiqnqtfs tpasqlfsph gsnpstpaat pvptaspvka
      241 inhpsasaaa tvsgmnllnt vlpvfpgqvs savhtpqpsi pnptvirtps lptapvtsih
      301 sttttpvpsi fsglvslpgp satptaatpt pgptprstlg sseafastsa pftslpfsts
      361 ssaastsnpn saslssvfag lplplpptsq glsnptpvia ggstpsvagp lgvnspllsa
      421 lkgfltsndt nlinssalss avtsglasls sltlqnsdss asapnkcyap saiptpqrts
      481 tpglalfpgl pspvanstst pltlpvqspl ataasastsv pvscgssasl lrgphpgtsd
      541 lhisstpaat tlpvmiktep tsptpsafkg pshsgnpshg tlglsgtlgr aytstsvpis
      601 lsaclnpals glsslstpln gsnplssisl pphgsstpia pvftalpsft sltnnfpltg
      661 npslnpsvsl pgsliatsst aatstslphp sstaavlsgl sasapvsaap fplnlstavp
      721 slfsvtqgpl sssnpsypgf svsntpsvtp alpsfpglqa pstvaavtpl pvaatapspa
      781 pvlpgfasaf ssnfnsalva qaglssglqa agssvfpgll slpgipgfpq npsqsslqel
      841 qhnaaaqsal lqqvhsasal esypaqpdgf psypsapgtp fslqpslsqs gwq
//
LOCUS       XP_016876246             824 aa            linear   PRI 05-AUG-2025
DEFINITION  intraflagellar transport protein 88 homolog isoform X1 [Homo
            sapiens].
ACCESSION   XP_016876246
VERSION     XP_016876246.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020757.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..824
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..824
                     /product="intraflagellar transport protein 88 homolog
                     isoform X1"
                     /calculated_mol_wt=93061
     Region          197..225
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          <203..712
                     /region_name="PEP_TPR_lipo"
                     /note="putative PEP-CTERM system TPR-repeat lipoprotein;
                     TIGR02917"
                     /db_xref="CDD:274350"
     Site            order(238,241..242,244,273,276..277,280..281,283..284,306,
                     309..310,313..314,317)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          238..261
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          271..301
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          305..332
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          419..442
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          452..478
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          459..713
                     /region_name="LapB"
                     /note="Lipopolysaccharide biosynthesis regulator
                     YciM/LapB, contains six TPR domains and a C-terminal
                     metal-binding domain [Cell wall/membrane/envelope
                     biogenesis]; COG2956"
                     /db_xref="CDD:442196"
     Region          484..512
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(485,488..489,492..493,495,519,522..523,526..527,
                     529..530,553,556..557,560..561,564)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          517..547
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          552..580
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          586..614
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          620..646
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          654..678
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          688..715
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..824
                     /gene="IFT88"
                     /gene_synonym="D13S1056E; DAF19; hTg737; TG737; TTC10"
                     /coded_by="XM_017020757.2:445..2919"
                     /db_xref="GeneID:8100"
                     /db_xref="HGNC:HGNC:20606"
                     /db_xref="MIM:600595"
ORIGIN      
        1 mmqnvhlape tdeddlysgy ndynpiydie elendaafqq avrtshgrrp pitakissta
       61 vtrpiatgyg sktslassig rpmtgaiqdg vtrpmtavra agftkaalrg safdplsqsr
      121 gpaspleakk kdspeekikq lekevnelve escianscgd lklalekakd agrkervlvr
      181 qreqvttpen inldltysvl fnlasqysvn emyaealnty qvivknkmfs nagilkmnmg
      241 niylkqrnys kaikfyrmal dqvpsvnkqm rikimqnigv tfiqagqysd ainsyehims
      301 mapnlkagyn lticyfaigd rekmkkafqk litvpleide dkyispsddp htnlvteaik
      361 ndhlrqmere rkamaekyim tsakliapvi etsfaagydw cvevvkasqy velandlein
      421 kavtylrqkd ynqaveilkv lekkdsrvks aaatnlsaly ymgkdfaqas syadiavnsd
      481 rynpaaltnk gntvfangdy ekaaefykea lrndssctea lynigltyek lnrldealdc
      541 flklhailrn saevlyqian iyelmenpsq aiewlmqvvs viptdpqvls klgelydreg
      601 dksqafqyyy esyryfpcni eviewlgayy idtqfwekai qyferasliq ptqvkwqlmv
      661 ascfrrsgny qkaldtykdt hrkfpenvec lrflvrlctd lglkdaqeya rklkrlekmk
      721 eireqriksg rdgsggsrgk regsasgdsg qnysasskge rlsarlralp gtnepyesss
      781 nkeidasyvd plgpqierpk taakkrided dfadeelgdd llpe
//
LOCUS       XP_047286612             814 aa            linear   PRI 05-AUG-2025
DEFINITION  intraflagellar transport protein 88 homolog isoform X2 [Homo
            sapiens].
ACCESSION   XP_047286612
VERSION     XP_047286612.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430656.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..814
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..814
                     /product="intraflagellar transport protein 88 homolog
                     isoform X2"
                     /calculated_mol_wt=92250
     Region          187..215
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          <193..702
                     /region_name="PEP_TPR_lipo"
                     /note="putative PEP-CTERM system TPR-repeat lipoprotein;
                     TIGR02917"
                     /db_xref="CDD:274350"
     Site            order(228,231..232,234,263,266..267,270..271,273..274,296,
                     299..300,303..304,307)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          228..251
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          261..291
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          295..322
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          409..432
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          442..468
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          449..703
                     /region_name="LapB"
                     /note="Lipopolysaccharide biosynthesis regulator
                     YciM/LapB, contains six TPR domains and a C-terminal
                     metal-binding domain [Cell wall/membrane/envelope
                     biogenesis]; COG2956"
                     /db_xref="CDD:442196"
     Region          474..502
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(475,478..479,482..483,485,509,512..513,516..517,
                     519..520,543,546..547,550..551,554)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          507..537
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          542..570
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          576..604
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          610..636
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          644..668
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          678..705
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..814
                     /gene="IFT88"
                     /gene_synonym="D13S1056E; DAF19; hTg737; TG737; TTC10"
                     /coded_by="XM_047430656.1:309..2753"
                     /db_xref="GeneID:8100"
                     /db_xref="HGNC:HGNC:20606"
                     /db_xref="MIM:600595"
ORIGIN      
        1 mkftntkvqm mqnvhlapet deddlysgyn dynpiydiee lendaafqqa vrtshgrrpp
       61 sktslassig rpmtgaiqdg vtrpmtavra agftkaalrg safdplsqsr gpaspleakk
      121 kdspeekikq lekevnelve escianscgd lklalekakd agrkervlvr qreqvttpen
      181 inldltysvl fnlasqysvn emyaealnty qvivknkmfs nagilkmnmg niylkqrnys
      241 kaikfyrmal dqvpsvnkqm rikimqnigv tfiqagqysd ainsyehims mapnlkagyn
      301 lticyfaigd rekmkkafqk litvpleide dkyispsddp htnlvteaik ndhlrqmere
      361 rkamaekyim tsakliapvi etsfaagydw cvevvkasqy velandlein kavtylrqkd
      421 ynqaveilkv lekkdsrvks aaatnlsaly ymgkdfaqas syadiavnsd rynpaaltnk
      481 gntvfangdy ekaaefykea lrndssctea lynigltyek lnrldealdc flklhailrn
      541 saevlyqian iyelmenpsq aiewlmqvvs viptdpqvls klgelydreg dksqafqyyy
      601 esyryfpcni eviewlgayy idtqfwekai qyferasliq ptqvkwqlmv ascfrrsgny
      661 qkaldtykdt hrkfpenvec lrflvrlctd lglkdaqeya rklkrlekmk eireqriksg
      721 rdgsggsrgk regsasgdsg qnysasskge rlsarlralp gtnepyesss nkeidasyvd
      781 plgpqierpk taakkrided dfadeelgdd llpe
//
LOCUS       XP_047286616             804 aa            linear   PRI 05-AUG-2025
DEFINITION  intraflagellar transport protein 88 homolog isoform X4 [Homo
            sapiens].
ACCESSION   XP_047286616
VERSION     XP_047286616.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430660.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..804
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..804
                     /product="intraflagellar transport protein 88 homolog
                     isoform X4"
                     /calculated_mol_wt=90950
     Region          206..234
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          210..557
                     /region_name="LapB"
                     /note="Lipopolysaccharide biosynthesis regulator
                     YciM/LapB, contains six TPR domains and a C-terminal
                     metal-binding domain [Cell wall/membrane/envelope
                     biogenesis]; COG2956"
                     /db_xref="CDD:442196"
     Site            order(247,250..251,253,282,285..286,289..290,292..293,315,
                     318..319,322..323,326)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          247..270
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          280..310
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          314..341
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          399..422
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          432..458
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          439..693
                     /region_name="LapB"
                     /note="Lipopolysaccharide biosynthesis regulator
                     YciM/LapB, contains six TPR domains and a C-terminal
                     metal-binding domain [Cell wall/membrane/envelope
                     biogenesis]; COG2956"
                     /db_xref="CDD:442196"
     Region          464..492
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(465,468..469,472..473,475,499,502..503,506..507,
                     509..510,533,536..537,540..541,544)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          497..527
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          532..560
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          566..594
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          600..626
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          634..658
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          668..695
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..804
                     /gene="IFT88"
                     /gene_synonym="D13S1056E; DAF19; hTg737; TG737; TTC10"
                     /coded_by="XM_047430660.1:309..2723"
                     /db_xref="GeneID:8100"
                     /db_xref="HGNC:HGNC:20606"
                     /db_xref="MIM:600595"
ORIGIN      
        1 mkftntkvqm mqnvhlapet deddlysgyn dynpiydiee lendaafqqa vrtshgrrpp
       61 itakisstav trpiatgygs ktslassigr pmtgaiqdgv trpmtavraa gftkaalrgs
      121 afdplsqsrg paspleakkk dspeekikql ekevnelvee scianscgdl klalekakda
      181 grkervlvrq reqvttpeni nldltysvlf nlasqysvne myaealntyq vivknkmfsn
      241 agilkmnmgn iylkqrnysk aikfyrmald qvpsvnkqmr ikimqnigvt fiqagqysda
      301 insyehimsm apnlkagynl ticyfaigdr ekmkkafqkl itvpleided kyispsddph
      361 tnlvteaikn dhlrqmerer cvevvkasqy velandlein kavtylrqkd ynqaveilkv
      421 lekkdsrvks aaatnlsaly ymgkdfaqas syadiavnsd rynpaaltnk gntvfangdy
      481 ekaaefykea lrndssctea lynigltyek lnrldealdc flklhailrn saevlyqian
      541 iyelmenpsq aiewlmqvvs viptdpqvls klgelydreg dksqafqyyy esyryfpcni
      601 eviewlgayy idtqfwekai qyferasliq ptqvkwqlmv ascfrrsgny qkaldtykdt
      661 hrkfpenvec lrflvrlctd lglkdaqeya rklkrlekmk eireqriksg rdgsggsrgk
      721 regsasgdsg qnysasskge rlsarlralp gtnepyesss nkeidasyvd plgpqierpk
      781 taakkrided dfadeelgdd llpe
//
LOCUS       XP_016876251             796 aa            linear   PRI 05-AUG-2025
DEFINITION  intraflagellar transport protein 88 homolog isoform X6 [Homo
            sapiens].
ACCESSION   XP_016876251
VERSION     XP_016876251.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020762.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..796
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..796
                     /product="intraflagellar transport protein 88 homolog
                     isoform X6"
                     /calculated_mol_wt=90157
     Region          206..234
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          <212..721
                     /region_name="PEP_TPR_lipo"
                     /note="putative PEP-CTERM system TPR-repeat lipoprotein;
                     TIGR02917"
                     /db_xref="CDD:274350"
     Site            order(247,250..251,253,282,285..286,289..290,292..293,315,
                     318..319,322..323,326)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          247..270
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          280..310
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          314..341
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          428..451
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          461..487
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          468..722
                     /region_name="LapB"
                     /note="Lipopolysaccharide biosynthesis regulator
                     YciM/LapB, contains six TPR domains and a C-terminal
                     metal-binding domain [Cell wall/membrane/envelope
                     biogenesis]; COG2956"
                     /db_xref="CDD:442196"
     Region          493..521
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(494,497..498,501..502,504,528,531..532,535..536,
                     538..539,562,565..566,569..570,573)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          526..556
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          561..589
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          595..623
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          629..655
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          663..687
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          697..724
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..796
                     /gene="IFT88"
                     /gene_synonym="D13S1056E; DAF19; hTg737; TG737; TTC10"
                     /coded_by="XM_017020762.2:408..2798"
                     /db_xref="GeneID:8100"
                     /db_xref="HGNC:HGNC:20606"
                     /db_xref="MIM:600595"
ORIGIN      
        1 mkftntkvqm mqnvhlapet deddlysgyn dynpiydiee lendaafqqa vrtshgrrpp
       61 itakisstav trpiatgygs ktslassigr pmtgaiqdgv trpmtavraa gftkaalrgs
      121 afdplsqsrg paspleakkk dspeekikql ekevnelvee scianscgdl klalekakda
      181 grkervlvrq reqvttpeni nldltysvlf nlasqysvne myaealntyq vivknkmfsn
      241 agilkmnmgn iylkqrnysk aikfyrmald qvpsvnkqmr ikimqnigvt fiqagqysda
      301 insyehimsm apnlkagynl ticyfaigdr ekmkkafqkl itvpleided kyispsddph
      361 tnlvteaikn dhlrqmerer kamaekyimt sakliapvie tsfaagydwc vevvkasqyv
      421 elandleink avtylrqkdy nqaveilkvl ekkdsrvksa aatnlsalyy mgkdfaqass
      481 yadiavnsdr ynpaaltnkg ntvfangdye kaaefykeal rndsscteal ynigltyekl
      541 nrldealdcf lklhailrns aevlyqiani yelmenpsqa iewlmqvvsv iptdpqvlsk
      601 lgelydregd ksqafqyyye syryfpcnie viewlgayyi dtqfwekaiq yferasliqp
      661 tqvkwqlmva scfrrsgnyq kaldtykdth rkfpenvecl rflvrlctdl glkdaqeyar
      721 klkrlekmke ireqriksgr dgsggsrgkr egsasgdasy vdplgpqier pktaakkrid
      781 eddfadeelg ddllpe
//
LOCUS       XP_047286620             795 aa            linear   PRI 05-AUG-2025
DEFINITION  intraflagellar transport protein 88 homolog isoform X8 [Homo
            sapiens].
ACCESSION   XP_047286620
VERSION     XP_047286620.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430664.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..795
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..795
                     /product="intraflagellar transport protein 88 homolog
                     isoform X8"
                     /calculated_mol_wt=90540
     Region          206..234
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          208..>341
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Site            order(247,250..251,253,282,285..286,289..290,292..293,315,
                     318..319,322..323,326)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          247..270
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          280..310
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          314..341
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          428..451
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          430..688
                     /region_name="LapB"
                     /note="Lipopolysaccharide biosynthesis regulator
                     YciM/LapB, contains six TPR domains and a C-terminal
                     metal-binding domain [Cell wall/membrane/envelope
                     biogenesis]; COG2956"
                     /db_xref="CDD:442196"
     Region          461..487
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          493..521
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(494,497..498,501..502,504,528,531..532,535..536,
                     538..539,562,565..566,569..570,573)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          526..556
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          561..589
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          595..623
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          629..655
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          663..687
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..795
                     /gene="IFT88"
                     /gene_synonym="D13S1056E; DAF19; hTg737; TG737; TTC10"
                     /coded_by="XM_047430664.1:193..2580"
                     /db_xref="GeneID:8100"
                     /db_xref="HGNC:HGNC:20606"
                     /db_xref="MIM:600595"
ORIGIN      
        1 mkftntkvqm mqnvhlapet deddlysgyn dynpiydiee lendaafqqa vrtshgrrpp
       61 itakisstav trpiatgygs ktslassigr pmtgaiqdgv trpmtavraa gftkaalrgs
      121 afdplsqsrg paspleakkk dspeekikql ekevnelvee scianscgdl klalekakda
      181 grkervlvrq reqvttpeni nldltysvlf nlasqysvne myaealntyq vivknkmfsn
      241 agilkmnmgn iylkqrnysk aikfyrmald qvpsvnkqmr ikimqnigvt fiqagqysda
      301 insyehimsm apnlkagynl ticyfaigdr ekmkkafqkl itvpleided kyispsddph
      361 tnlvteaikn dhlrqmerer kamaekyimt sakliapvie tsfaagydwc vevvkasqyv
      421 elandleink avtylrqkdy nqaveilkvl ekkdsrvksa aatnlsalyy mgkdfaqass
      481 yadiavnsdr ynpaaltnkg ntvfangdye kaaefykeal rndsscteal ynigltyekl
      541 nrldealdcf lklhailrns aevlyqiani yelmenpsqa iewlmqvvsv iptdpqvlsk
      601 lgelydregd ksqafqyyye syryfpcnie viewlgayyi dtqfwekaiq yferasliqp
      661 tqvkwqlmva scfrrsgnyq kaldtykdth rkfpenvecs gsvrtghmer dplnllprks
      721 vlpgpeiakc nyfsgekyyl saflssslhr swikrcsric qkteevgkne rnkgtahkvr
      781 qrwqwglpwq krrkc
//
LOCUS       XP_016876252             795 aa            linear   PRI 05-AUG-2025
DEFINITION  intraflagellar transport protein 88 homolog isoform X8 [Homo
            sapiens].
ACCESSION   XP_016876252
VERSION     XP_016876252.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020763.2
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 12% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..795
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..795
                     /product="intraflagellar transport protein 88 homolog
                     isoform X8"
                     /calculated_mol_wt=90540
     Region          206..234
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          208..>341
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Site            order(247,250..251,253,282,285..286,289..290,292..293,315,
                     318..319,322..323,326)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          247..270
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          280..310
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          314..341
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          428..451
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          430..688
                     /region_name="LapB"
                     /note="Lipopolysaccharide biosynthesis regulator
                     YciM/LapB, contains six TPR domains and a C-terminal
                     metal-binding domain [Cell wall/membrane/envelope
                     biogenesis]; COG2956"
                     /db_xref="CDD:442196"
     Region          461..487
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          493..521
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(494,497..498,501..502,504,528,531..532,535..536,
                     538..539,562,565..566,569..570,573)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          526..556
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          561..589
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          595..623
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          629..655
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          663..687
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..795
                     /gene="IFT88"
                     /gene_synonym="D13S1056E; DAF19; hTg737; TG737; TTC10"
                     /coded_by="XM_017020763.2:408..2795"
                     /db_xref="GeneID:8100"
                     /db_xref="HGNC:HGNC:20606"
                     /db_xref="MIM:600595"
ORIGIN      
        1 mkftntkvqm mqnvhlapet deddlysgyn dynpiydiee lendaafqqa vrtshgrrpp
       61 itakisstav trpiatgygs ktslassigr pmtgaiqdgv trpmtavraa gftkaalrgs
      121 afdplsqsrg paspleakkk dspeekikql ekevnelvee scianscgdl klalekakda
      181 grkervlvrq reqvttpeni nldltysvlf nlasqysvne myaealntyq vivknkmfsn
      241 agilkmnmgn iylkqrnysk aikfyrmald qvpsvnkqmr ikimqnigvt fiqagqysda
      301 insyehimsm apnlkagynl ticyfaigdr ekmkkafqkl itvpleided kyispsddph
      361 tnlvteaikn dhlrqmerer kamaekyimt sakliapvie tsfaagydwc vevvkasqyv
      421 elandleink avtylrqkdy nqaveilkvl ekkdsrvksa aatnlsalyy mgkdfaqass
      481 yadiavnsdr ynpaaltnkg ntvfangdye kaaefykeal rndsscteal ynigltyekl
      541 nrldealdcf lklhailrns aevlyqiani yelmenpsqa iewlmqvvsv iptdpqvlsk
      601 lgelydregd ksqafqyyye syryfpcnie viewlgayyi dtqfwekaiq yferasliqp
      661 tqvkwqlmva scfrrsgnyq kaldtykdth rkfpenvecs gsvrtghmer dplnllprks
      721 vlpgpeiakc nyfsgekyyl saflssslhr swikrcsric qkteevgkne rnkgtahkvr
      781 qrwqwglpwq krrkc
//
LOCUS       XP_047286621             790 aa            linear   PRI 05-AUG-2025
DEFINITION  intraflagellar transport protein 88 homolog isoform X9 [Homo
            sapiens].
ACCESSION   XP_047286621
VERSION     XP_047286621.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430665.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..790
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..790
                     /product="intraflagellar transport protein 88 homolog
                     isoform X9"
                     /calculated_mol_wt=89322
     Region          197..225
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(198,201..202,205..206,208,234,237..238,241..242,
                     244..245,273,276..277,280..281,284)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          201..543
                     /region_name="LapB"
                     /note="Lipopolysaccharide biosynthesis regulator
                     YciM/LapB, contains six TPR domains and a C-terminal
                     metal-binding domain [Cell wall/membrane/envelope
                     biogenesis]; COG2956"
                     /db_xref="CDD:442196"
     Region          232..262
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          272..298
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          385..408
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          418..444
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          425..679
                     /region_name="LapB"
                     /note="Lipopolysaccharide biosynthesis regulator
                     YciM/LapB, contains six TPR domains and a C-terminal
                     metal-binding domain [Cell wall/membrane/envelope
                     biogenesis]; COG2956"
                     /db_xref="CDD:442196"
     Region          450..478
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(451,454..455,458..459,461,485,488..489,492..493,
                     495..496,519,522..523,526..527,530)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          483..513
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          518..546
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          552..580
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          586..612
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          620..644
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          654..681
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..790
                     /gene="IFT88"
                     /gene_synonym="D13S1056E; DAF19; hTg737; TG737; TTC10"
                     /coded_by="XM_047430665.1:117..2489"
                     /db_xref="GeneID:8100"
                     /db_xref="HGNC:HGNC:20606"
                     /db_xref="MIM:600595"
ORIGIN      
        1 mmqnvhlape tdeddlysgy ndynpiydie elendaafqq avrtshgrrp pitakissta
       61 vtrpiatgyg sktslassig rpmtgaiqdg vtrpmtavra agftkaalrg safdplsqsr
      121 gpaspleakk kdspeekikq lekevnelve escianscgd lklalekakd agrkervlvr
      181 qreqvttpen inldltysvl fnlasqysvn emyaealnty qvivknkmfs nagilkmnmg
      241 niylkqrnys kaikfyrmal dqvpsvnkqm rikimqnigv tfiqadrekm kkafqklitv
      301 pleidedkyi spsddphtnl vteaikndhl rqmererkam aekyimtsak liapvietsf
      361 aagydwcvev vkasqyvela ndleinkavt ylrqkdynqa veilkvlekk dsrvksaaat
      421 nlsalyymgk dfaqassyad iavnsdrynp aaltnkgntv fangdyekaa efykealrnd
      481 ssctealyni gltyeklnrl dealdcflkl hailrnsaev lyqianiyel menpsqaiew
      541 lmqvvsvipt dpqvlsklge lydregdksq afqyyyesyr yfpcnievie wlgayyidtq
      601 fwekaiqyfe rasliqptqv kwqlmvascf rrsgnyqkal dtykdthrkf penveclrfl
      661 vrlctdlglk daqeyarklk rlekmkeire qriksgrdgs ggsrgkregs asgdsgqnys
      721 asskgerlsa rlralpgtne pyesssnkei dasyvdplgp qierpktaak krideddfad
      781 eelgddllpe
//
LOCUS       XP_047286623             785 aa            linear   PRI 05-AUG-2025
DEFINITION  intraflagellar transport protein 88 homolog isoform X11 [Homo
            sapiens].
ACCESSION   XP_047286623
VERSION     XP_047286623.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430667.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..785
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..785
                     /product="intraflagellar transport protein 88 homolog
                     isoform X11"
                     /calculated_mol_wt=89061
     Region          187..215
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          191..538
                     /region_name="LapB"
                     /note="Lipopolysaccharide biosynthesis regulator
                     YciM/LapB, contains six TPR domains and a C-terminal
                     metal-binding domain [Cell wall/membrane/envelope
                     biogenesis]; COG2956"
                     /db_xref="CDD:442196"
     Site            order(228,231..232,234,263,266..267,270..271,273..274,296,
                     299..300,303..304,307)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          228..251
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          261..291
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          295..322
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          380..403
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          413..439
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          420..674
                     /region_name="LapB"
                     /note="Lipopolysaccharide biosynthesis regulator
                     YciM/LapB, contains six TPR domains and a C-terminal
                     metal-binding domain [Cell wall/membrane/envelope
                     biogenesis]; COG2956"
                     /db_xref="CDD:442196"
     Region          445..473
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(446,449..450,453..454,456,480,483..484,487..488,
                     490..491,514,517..518,521..522,525)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          478..508
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          513..541
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          547..575
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          581..607
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          615..639
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          649..676
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..785
                     /gene="IFT88"
                     /gene_synonym="D13S1056E; DAF19; hTg737; TG737; TTC10"
                     /coded_by="XM_047430667.1:300..2657"
                     /db_xref="GeneID:8100"
                     /db_xref="HGNC:HGNC:20606"
                     /db_xref="MIM:600595"
ORIGIN      
        1 mkftntkvqm mqnvhlapet deddlysgyn dynpiydiee lendaafqqa vrtshgrrpp
       61 sktslassig rpmtgaiqdg vtrpmtavra agftkaalrg safdplsqsr gpaspleakk
      121 kdspeekikq lekevnelve escianscgd lklalekakd agrkervlvr qreqvttpen
      181 inldltysvl fnlasqysvn emyaealnty qvivknkmfs nagilkmnmg niylkqrnys
      241 kaikfyrmal dqvpsvnkqm rikimqnigv tfiqagqysd ainsyehims mapnlkagyn
      301 lticyfaigd rekmkkafqk litvpleide dkyispsddp htnlvteaik ndhlrqmere
      361 rcvevvkasq yvelandlei nkavtylrqk dynqaveilk vlekkdsrvk saaatnlsal
      421 yymgkdfaqa ssyadiavns drynpaaltn kgntvfangd yekaaefyke alrndsscte
      481 alynigltye klnrldeald cflklhailr nsaevlyqia niyelmenps qaiewlmqvv
      541 sviptdpqvl sklgelydre gdksqafqyy yesyryfpcn ieviewlgay yidtqfweka
      601 iqyferasli qptqvkwqlm vascfrrsgn yqkaldtykd thrkfpenve clrflvrlct
      661 dlglkdaqey arklkrlekm keireqriks grdgsggsrg kregsasgds gqnysasskg
      721 erlsarlral pgtnepyess snkeidasyv dplgpqierp ktaakkride ddfadeelgd
      781 dllpe
//
LOCUS       XP_024305181             780 aa            linear   PRI 05-AUG-2025
DEFINITION  intraflagellar transport protein 88 homolog isoform X12 [Homo
            sapiens].
ACCESSION   XP_024305181
VERSION     XP_024305181.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449413.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..780
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..780
                     /product="intraflagellar transport protein 88 homolog
                     isoform X12"
                     /calculated_mol_wt=88511
     Region          187..215
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(188,191..192,195..196,198,224,227..228,231..232,
                     234..235,263,266..267,270..271,274)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          191..533
                     /region_name="LapB"
                     /note="Lipopolysaccharide biosynthesis regulator
                     YciM/LapB, contains six TPR domains and a C-terminal
                     metal-binding domain [Cell wall/membrane/envelope
                     biogenesis]; COG2956"
                     /db_xref="CDD:442196"
     Region          222..252
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          262..288
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          375..398
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          408..434
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          415..669
                     /region_name="LapB"
                     /note="Lipopolysaccharide biosynthesis regulator
                     YciM/LapB, contains six TPR domains and a C-terminal
                     metal-binding domain [Cell wall/membrane/envelope
                     biogenesis]; COG2956"
                     /db_xref="CDD:442196"
     Region          440..468
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(441,444..445,448..449,451,475,478..479,482..483,
                     485..486,509,512..513,516..517,520)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          473..503
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          508..536
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          542..570
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          576..602
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          610..634
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          644..671
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..780
                     /gene="IFT88"
                     /gene_synonym="D13S1056E; DAF19; hTg737; TG737; TTC10"
                     /coded_by="XM_024449413.2:408..2750"
                     /db_xref="GeneID:8100"
                     /db_xref="HGNC:HGNC:20606"
                     /db_xref="MIM:600595"
ORIGIN      
        1 mkftntkvqm mqnvhlapet deddlysgyn dynpiydiee lendaafqqa vrtshgrrpp
       61 sktslassig rpmtgaiqdg vtrpmtavra agftkaalrg safdplsqsr gpaspleakk
      121 kdspeekikq lekevnelve escianscgd lklalekakd agrkervlvr qreqvttpen
      181 inldltysvl fnlasqysvn emyaealnty qvivknkmfs nagilkmnmg niylkqrnys
      241 kaikfyrmal dqvpsvnkqm rikimqnigv tfiqadrekm kkafqklitv pleidedkyi
      301 spsddphtnl vteaikndhl rqmererkam aekyimtsak liapvietsf aagydwcvev
      361 vkasqyvela ndleinkavt ylrqkdynqa veilkvlekk dsrvksaaat nlsalyymgk
      421 dfaqassyad iavnsdrynp aaltnkgntv fangdyekaa efykealrnd ssctealyni
      481 gltyeklnrl dealdcflkl hailrnsaev lyqianiyel menpsqaiew lmqvvsvipt
      541 dpqvlsklge lydregdksq afqyyyesyr yfpcnievie wlgayyidtq fwekaiqyfe
      601 rasliqptqv kwqlmvascf rrsgnyqkal dtykdthrkf penveclrfl vrlctdlglk
      661 daqeyarklk rlekmkeire qriksgrdgs ggsrgkregs asgdsgqnys asskgerlsa
      721 rlralpgtne pyesssnkei dasyvdplgp qierpktaak krideddfad eelgddllpe
//
LOCUS       XP_047286624             780 aa            linear   PRI 05-AUG-2025
DEFINITION  intraflagellar transport protein 88 homolog isoform X12 [Homo
            sapiens].
ACCESSION   XP_047286624
VERSION     XP_047286624.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430668.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..780
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..780
                     /product="intraflagellar transport protein 88 homolog
                     isoform X12"
                     /calculated_mol_wt=88511
     Region          187..215
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(188,191..192,195..196,198,224,227..228,231..232,
                     234..235,263,266..267,270..271,274)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          191..533
                     /region_name="LapB"
                     /note="Lipopolysaccharide biosynthesis regulator
                     YciM/LapB, contains six TPR domains and a C-terminal
                     metal-binding domain [Cell wall/membrane/envelope
                     biogenesis]; COG2956"
                     /db_xref="CDD:442196"
     Region          222..252
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          262..288
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          375..398
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          408..434
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          415..669
                     /region_name="LapB"
                     /note="Lipopolysaccharide biosynthesis regulator
                     YciM/LapB, contains six TPR domains and a C-terminal
                     metal-binding domain [Cell wall/membrane/envelope
                     biogenesis]; COG2956"
                     /db_xref="CDD:442196"
     Region          440..468
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(441,444..445,448..449,451,475,478..479,482..483,
                     485..486,509,512..513,516..517,520)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          473..503
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          508..536
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          542..570
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          576..602
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          610..634
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          644..671
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..780
                     /gene="IFT88"
                     /gene_synonym="D13S1056E; DAF19; hTg737; TG737; TTC10"
                     /coded_by="XM_047430668.1:193..2535"
                     /db_xref="GeneID:8100"
                     /db_xref="HGNC:HGNC:20606"
                     /db_xref="MIM:600595"
ORIGIN      
        1 mkftntkvqm mqnvhlapet deddlysgyn dynpiydiee lendaafqqa vrtshgrrpp
       61 sktslassig rpmtgaiqdg vtrpmtavra agftkaalrg safdplsqsr gpaspleakk
      121 kdspeekikq lekevnelve escianscgd lklalekakd agrkervlvr qreqvttpen
      181 inldltysvl fnlasqysvn emyaealnty qvivknkmfs nagilkmnmg niylkqrnys
      241 kaikfyrmal dqvpsvnkqm rikimqnigv tfiqadrekm kkafqklitv pleidedkyi
      301 spsddphtnl vteaikndhl rqmererkam aekyimtsak liapvietsf aagydwcvev
      361 vkasqyvela ndleinkavt ylrqkdynqa veilkvlekk dsrvksaaat nlsalyymgk
      421 dfaqassyad iavnsdrynp aaltnkgntv fangdyekaa efykealrnd ssctealyni
      481 gltyeklnrl dealdcflkl hailrnsaev lyqianiyel menpsqaiew lmqvvsvipt
      541 dpqvlsklge lydregdksq afqyyyesyr yfpcnievie wlgayyidtq fwekaiqyfe
      601 rasliqptqv kwqlmvascf rrsgnyqkal dtykdthrkf penveclrfl vrlctdlglk
      661 daqeyarklk rlekmkeire qriksgrdgs ggsrgkregs asgdsgqnys asskgerlsa
      721 rlralpgtne pyesssnkei dasyvdplgp qierpktaak krideddfad eelgddllpe
//
LOCUS       XP_047286625             776 aa            linear   PRI 05-AUG-2025
DEFINITION  intraflagellar transport protein 88 homolog isoform X13 [Homo
            sapiens].
ACCESSION   XP_047286625
VERSION     XP_047286625.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430669.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..776
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..776
                     /product="intraflagellar transport protein 88 homolog
                     isoform X13"
                     /calculated_mol_wt=88650
     Region          187..215
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          189..>322
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Site            order(228,231..232,234,263,266..267,270..271,273..274,296,
                     299..300,303..304,307)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          228..251
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          261..291
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          295..322
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          409..432
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          411..669
                     /region_name="LapB"
                     /note="Lipopolysaccharide biosynthesis regulator
                     YciM/LapB, contains six TPR domains and a C-terminal
                     metal-binding domain [Cell wall/membrane/envelope
                     biogenesis]; COG2956"
                     /db_xref="CDD:442196"
     Region          442..468
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          474..502
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(475,478..479,482..483,485,509,512..513,516..517,
                     519..520,543,546..547,550..551,554)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          507..537
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          542..570
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          576..604
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          610..636
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          644..668
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..776
                     /gene="IFT88"
                     /gene_synonym="D13S1056E; DAF19; hTg737; TG737; TTC10"
                     /coded_by="XM_047430669.1:408..2738"
                     /db_xref="GeneID:8100"
                     /db_xref="HGNC:HGNC:20606"
                     /db_xref="MIM:600595"
ORIGIN      
        1 mkftntkvqm mqnvhlapet deddlysgyn dynpiydiee lendaafqqa vrtshgrrpp
       61 sktslassig rpmtgaiqdg vtrpmtavra agftkaalrg safdplsqsr gpaspleakk
      121 kdspeekikq lekevnelve escianscgd lklalekakd agrkervlvr qreqvttpen
      181 inldltysvl fnlasqysvn emyaealnty qvivknkmfs nagilkmnmg niylkqrnys
      241 kaikfyrmal dqvpsvnkqm rikimqnigv tfiqagqysd ainsyehims mapnlkagyn
      301 lticyfaigd rekmkkafqk litvpleide dkyispsddp htnlvteaik ndhlrqmere
      361 rkamaekyim tsakliapvi etsfaagydw cvevvkasqy velandlein kavtylrqkd
      421 ynqaveilkv lekkdsrvks aaatnlsaly ymgkdfaqas syadiavnsd rynpaaltnk
      481 gntvfangdy ekaaefykea lrndssctea lynigltyek lnrldealdc flklhailrn
      541 saevlyqian iyelmenpsq aiewlmqvvs viptdpqvls klgelydreg dksqafqyyy
      601 esyryfpcni eviewlgayy idtqfwekai qyferasliq ptqvkwqlmv ascfrrsgny
      661 qkaldtykdt hrkfpenvec sgsvrtghme rdplnllprk svlpgpeiak cnyfsgekyy
      721 lsaflssslh rswikrcsri cqkteevgkn ernkgtahkv rqrwqwglpw qkrrkc
//
LOCUS       XP_047286626             770 aa            linear   PRI 05-AUG-2025
DEFINITION  intraflagellar transport protein 88 homolog isoform X14 [Homo
            sapiens].
ACCESSION   XP_047286626
VERSION     XP_047286626.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430670.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..770
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..770
                     /product="intraflagellar transport protein 88 homolog
                     isoform X14"
                     /calculated_mol_wt=87211
     Region          205..460
                     /region_name="LapB"
                     /note="Lipopolysaccharide biosynthesis regulator
                     YciM/LapB, contains six TPR domains and a C-terminal
                     metal-binding domain [Cell wall/membrane/envelope
                     biogenesis]; COG2956"
                     /db_xref="CDD:442196"
     Region          206..234
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(207,210..211,214..215,217,243,246..247,250..251,
                     253..254,282,285..286,289..290,293)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          241..271
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          281..307
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          365..388
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          398..424
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          405..659
                     /region_name="LapB"
                     /note="Lipopolysaccharide biosynthesis regulator
                     YciM/LapB, contains six TPR domains and a C-terminal
                     metal-binding domain [Cell wall/membrane/envelope
                     biogenesis]; COG2956"
                     /db_xref="CDD:442196"
     Region          430..458
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(431,434..435,438..439,441,465,468..469,472..473,
                     475..476,499,502..503,506..507,510)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          463..493
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          498..526
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          532..560
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          566..592
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          600..624
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          634..661
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..770
                     /gene="IFT88"
                     /gene_synonym="D13S1056E; DAF19; hTg737; TG737; TTC10"
                     /coded_by="XM_047430670.1:309..2621"
                     /db_xref="GeneID:8100"
                     /db_xref="HGNC:HGNC:20606"
                     /db_xref="MIM:600595"
ORIGIN      
        1 mkftntkvqm mqnvhlapet deddlysgyn dynpiydiee lendaafqqa vrtshgrrpp
       61 itakisstav trpiatgygs ktslassigr pmtgaiqdgv trpmtavraa gftkaalrgs
      121 afdplsqsrg paspleakkk dspeekikql ekevnelvee scianscgdl klalekakda
      181 grkervlvrq reqvttpeni nldltysvlf nlasqysvne myaealntyq vivknkmfsn
      241 agilkmnmgn iylkqrnysk aikfyrmald qvpsvnkqmr ikimqnigvt fiqadrekmk
      301 kafqklitvp leidedkyis psddphtnlv teaikndhlr qmerercvev vkasqyvela
      361 ndleinkavt ylrqkdynqa veilkvlekk dsrvksaaat nlsalyymgk dfaqassyad
      421 iavnsdrynp aaltnkgntv fangdyekaa efykealrnd ssctealyni gltyeklnrl
      481 dealdcflkl hailrnsaev lyqianiyel menpsqaiew lmqvvsvipt dpqvlsklge
      541 lydregdksq afqyyyesyr yfpcnievie wlgayyidtq fwekaiqyfe rasliqptqv
      601 kwqlmvascf rrsgnyqkal dtykdthrkf penveclrfl vrlctdlglk daqeyarklk
      661 rlekmkeire qriksgrdgs ggsrgkregs asgdsgqnys asskgerlsa rlralpgtne
      721 pyesssnkei dasyvdplgp qierpktaak krideddfad eelgddllpe
//
LOCUS       XP_047286627             770 aa            linear   PRI 05-AUG-2025
DEFINITION  intraflagellar transport protein 88 homolog isoform X14 [Homo
            sapiens].
ACCESSION   XP_047286627
VERSION     XP_047286627.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430671.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..770
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..770
                     /product="intraflagellar transport protein 88 homolog
                     isoform X14"
                     /calculated_mol_wt=87211
     Region          205..460
                     /region_name="LapB"
                     /note="Lipopolysaccharide biosynthesis regulator
                     YciM/LapB, contains six TPR domains and a C-terminal
                     metal-binding domain [Cell wall/membrane/envelope
                     biogenesis]; COG2956"
                     /db_xref="CDD:442196"
     Region          206..234
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(207,210..211,214..215,217,243,246..247,250..251,
                     253..254,282,285..286,289..290,293)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          241..271
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          281..307
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          365..388
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          398..424
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          405..659
                     /region_name="LapB"
                     /note="Lipopolysaccharide biosynthesis regulator
                     YciM/LapB, contains six TPR domains and a C-terminal
                     metal-binding domain [Cell wall/membrane/envelope
                     biogenesis]; COG2956"
                     /db_xref="CDD:442196"
     Region          430..458
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(431,434..435,438..439,441,465,468..469,472..473,
                     475..476,499,502..503,506..507,510)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          463..493
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          498..526
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          532..560
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          566..592
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          600..624
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          634..661
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..770
                     /gene="IFT88"
                     /gene_synonym="D13S1056E; DAF19; hTg737; TG737; TTC10"
                     /coded_by="XM_047430671.1:300..2612"
                     /db_xref="GeneID:8100"
                     /db_xref="HGNC:HGNC:20606"
                     /db_xref="MIM:600595"
ORIGIN      
        1 mkftntkvqm mqnvhlapet deddlysgyn dynpiydiee lendaafqqa vrtshgrrpp
       61 itakisstav trpiatgygs ktslassigr pmtgaiqdgv trpmtavraa gftkaalrgs
      121 afdplsqsrg paspleakkk dspeekikql ekevnelvee scianscgdl klalekakda
      181 grkervlvrq reqvttpeni nldltysvlf nlasqysvne myaealntyq vivknkmfsn
      241 agilkmnmgn iylkqrnysk aikfyrmald qvpsvnkqmr ikimqnigvt fiqadrekmk
      301 kafqklitvp leidedkyis psddphtnlv teaikndhlr qmerercvev vkasqyvela
      361 ndleinkavt ylrqkdynqa veilkvlekk dsrvksaaat nlsalyymgk dfaqassyad
      421 iavnsdrynp aaltnkgntv fangdyekaa efykealrnd ssctealyni gltyeklnrl
      481 dealdcflkl hailrnsaev lyqianiyel menpsqaiew lmqvvsvipt dpqvlsklge
      541 lydregdksq afqyyyesyr yfpcnievie wlgayyidtq fwekaiqyfe rasliqptqv
      601 kwqlmvascf rrsgnyqkal dtykdthrkf penveclrfl vrlctdlglk daqeyarklk
      661 rlekmkeire qriksgrdgs ggsrgkregs asgdsgqnys asskgerlsa rlralpgtne
      721 pyesssnkei dasyvdplgp qierpktaak krideddfad eelgddllpe
//
LOCUS       XP_047286629             761 aa            linear   PRI 05-AUG-2025
DEFINITION  intraflagellar transport protein 88 homolog isoform X16 [Homo
            sapiens].
ACCESSION   XP_047286629
VERSION     XP_047286629.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430673.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..761
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..761
                     /product="intraflagellar transport protein 88 homolog
                     isoform X16"
                     /calculated_mol_wt=86133
     Region          196..451
                     /region_name="LapB"
                     /note="Lipopolysaccharide biosynthesis regulator
                     YciM/LapB, contains six TPR domains and a C-terminal
                     metal-binding domain [Cell wall/membrane/envelope
                     biogenesis]; COG2956"
                     /db_xref="CDD:442196"
     Region          197..225
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(198,201..202,205..206,208,234,237..238,241..242,
                     244..245,273,276..277,280..281,284)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          232..262
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          272..298
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          356..379
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          389..415
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          396..650
                     /region_name="LapB"
                     /note="Lipopolysaccharide biosynthesis regulator
                     YciM/LapB, contains six TPR domains and a C-terminal
                     metal-binding domain [Cell wall/membrane/envelope
                     biogenesis]; COG2956"
                     /db_xref="CDD:442196"
     Region          421..449
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(422,425..426,429..430,432,456,459..460,463..464,
                     466..467,490,493..494,497..498,501)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          454..484
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          489..517
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          523..551
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          557..583
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          591..615
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          625..652
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..761
                     /gene="IFT88"
                     /gene_synonym="D13S1056E; DAF19; hTg737; TG737; TTC10"
                     /coded_by="XM_047430673.1:107..2392"
                     /db_xref="GeneID:8100"
                     /db_xref="HGNC:HGNC:20606"
                     /db_xref="MIM:600595"
ORIGIN      
        1 mmqnvhlape tdeddlysgy ndynpiydie elendaafqq avrtshgrrp pitakissta
       61 vtrpiatgyg sktslassig rpmtgaiqdg vtrpmtavra agftkaalrg safdplsqsr
      121 gpaspleakk kdspeekikq lekevnelve escianscgd lklalekakd agrkervlvr
      181 qreqvttpen inldltysvl fnlasqysvn emyaealnty qvivknkmfs nagilkmnmg
      241 niylkqrnys kaikfyrmal dqvpsvnkqm rikimqnigv tfiqadrekm kkafqklitv
      301 pleidedkyi spsddphtnl vteaikndhl rqmerercve vvkasqyvel andleinkav
      361 tylrqkdynq aveilkvlek kdsrvksaaa tnlsalyymg kdfaqassya diavnsdryn
      421 paaltnkgnt vfangdyeka aefykealrn dssctealyn igltyeklnr ldealdcflk
      481 lhailrnsae vlyqianiye lmenpsqaie wlmqvvsvip tdpqvlsklg elydregdks
      541 qafqyyyesy ryfpcnievi ewlgayyidt qfwekaiqyf erasliqptq vkwqlmvasc
      601 frrsgnyqka ldtykdthrk fpenveclrf lvrlctdlgl kdaqeyarkl krlekmkeir
      661 eqriksgrdg sggsrgkreg sasgdsgqny sasskgerls arlralpgtn epyesssnke
      721 idasyvdplg pqierpktaa kkrideddfa deelgddllp e
//
LOCUS       XP_047286631             742 aa            linear   PRI 05-AUG-2025
DEFINITION  intraflagellar transport protein 88 homolog isoform X18 [Homo
            sapiens].
ACCESSION   XP_047286631
VERSION     XP_047286631.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430675.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..742
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..742
                     /product="intraflagellar transport protein 88 homolog
                     isoform X18"
                     /calculated_mol_wt=84244
     Region          177..432
                     /region_name="LapB"
                     /note="Lipopolysaccharide biosynthesis regulator
                     YciM/LapB, contains six TPR domains and a C-terminal
                     metal-binding domain [Cell wall/membrane/envelope
                     biogenesis]; COG2956"
                     /db_xref="CDD:442196"
     Region          178..206
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(179,182..183,186..187,189,215,218..219,222..223,
                     225..226,254,257..258,261..262,265)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          213..243
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          253..279
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          337..360
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          370..396
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          377..631
                     /region_name="LapB"
                     /note="Lipopolysaccharide biosynthesis regulator
                     YciM/LapB, contains six TPR domains and a C-terminal
                     metal-binding domain [Cell wall/membrane/envelope
                     biogenesis]; COG2956"
                     /db_xref="CDD:442196"
     Region          402..430
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(403,406..407,410..411,413,437,440..441,444..445,
                     447..448,471,474..475,478..479,482)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          435..465
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          470..498
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          504..532
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          538..564
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          572..596
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          606..633
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..742
                     /gene="IFT88"
                     /gene_synonym="D13S1056E; DAF19; hTg737; TG737; TTC10"
                     /coded_by="XM_047430675.1:107..2335"
                     /db_xref="GeneID:8100"
                     /db_xref="HGNC:HGNC:20606"
                     /db_xref="MIM:600595"
ORIGIN      
        1 mmqnvhlape tdeddlysgy ndynpiydie elendaafqq avrtshgrrp psktslassi
       61 grpmtgaiqd gvtrpmtavr aagftkaalr gsafdplsqs rgpaspleak kkdspeekik
      121 qlekevnelv eescianscg dlklalekak dagrkervlv rqreqvttpe ninldltysv
      181 lfnlasqysv nemyaealnt yqvivknkmf snagilkmnm gniylkqrny skaikfyrma
      241 ldqvpsvnkq mrikimqnig vtfiqadrek mkkafqklit vpleidedky ispsddphtn
      301 lvteaikndh lrqmerercv evvkasqyve landleinka vtylrqkdyn qaveilkvle
      361 kkdsrvksaa atnlsalyym gkdfaqassy adiavnsdry npaaltnkgn tvfangdyek
      421 aaefykealr ndssctealy nigltyekln rldealdcfl klhailrnsa evlyqianiy
      481 elmenpsqai ewlmqvvsvi ptdpqvlskl gelydregdk sqafqyyyes yryfpcniev
      541 iewlgayyid tqfwekaiqy ferasliqpt qvkwqlmvas cfrrsgnyqk aldtykdthr
      601 kfpenveclr flvrlctdlg lkdaqeyark lkrlekmkei reqriksgrd gsggsrgkre
      661 gsasgdsgqn ysasskgerl sarlralpgt nepyesssnk eidasyvdpl gpqierpkta
      721 akkrideddf adeelgddll pe
//
LOCUS       XP_047286632             710 aa            linear   PRI 05-AUG-2025
DEFINITION  intraflagellar transport protein 88 homolog isoform X19 [Homo
            sapiens].
ACCESSION   XP_047286632
VERSION     XP_047286632.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430676.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..710
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..710
                     /product="intraflagellar transport protein 88 homolog
                     isoform X19"
                     /calculated_mol_wt=80534
     Region          206..>341
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          206..234
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(247,250..251,253,282,285..286,289..290,292..293,315,
                     318..319,322..323,326)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          247..270
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          280..310
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          314..341
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          428..451
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          430..688
                     /region_name="LapB"
                     /note="Lipopolysaccharide biosynthesis regulator
                     YciM/LapB, contains six TPR domains and a C-terminal
                     metal-binding domain [Cell wall/membrane/envelope
                     biogenesis]; COG2956"
                     /db_xref="CDD:442196"
     Region          461..487
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          493..521
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(494,497..498,501..502,504,528,531..532,535..536,
                     538..539,562,565..566,569..570,573)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          526..556
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          561..589
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          595..623
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          629..655
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          663..687
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..710
                     /gene="IFT88"
                     /gene_synonym="D13S1056E; DAF19; hTg737; TG737; TTC10"
                     /coded_by="XM_047430676.1:408..2540"
                     /db_xref="GeneID:8100"
                     /db_xref="HGNC:HGNC:20606"
                     /db_xref="MIM:600595"
ORIGIN      
        1 mkftntkvqm mqnvhlapet deddlysgyn dynpiydiee lendaafqqa vrtshgrrpp
       61 itakisstav trpiatgygs ktslassigr pmtgaiqdgv trpmtavraa gftkaalrgs
      121 afdplsqsrg paspleakkk dspeekikql ekevnelvee scianscgdl klalekakda
      181 grkervlvrq reqvttpeni nldltysvlf nlasqysvne myaealntyq vivknkmfsn
      241 agilkmnmgn iylkqrnysk aikfyrmald qvpsvnkqmr ikimqnigvt fiqagqysda
      301 insyehimsm apnlkagynl ticyfaigdr ekmkkafqkl itvpleided kyispsddph
      361 tnlvteaikn dhlrqmerer kamaekyimt sakliapvie tsfaagydwc vevvkasqyv
      421 elandleink avtylrqkdy nqaveilkvl ekkdsrvksa aatnlsalyy mgkdfaqass
      481 yadiavnsdr ynpaaltnkg ntvfangdye kaaefykeal rndsscteal ynigltyekl
      541 nrldealdcf lklhailrns aevlyqiani yelmenpsqa iewlmqvvsv iptdpqvlsk
      601 lgelydregd ksqafqyyye syryfpcnie viewlgayyi dtqfwekaiq yferasliqp
      661 tqvkwqlmva scfrrsgnyq kaldtykdth rkfpenvefl cqqcpvpcsf
//
LOCUS       XP_016876264             487 aa            linear   PRI 05-AUG-2025
DEFINITION  intraflagellar transport protein 88 homolog isoform X20 [Homo
            sapiens].
ACCESSION   XP_016876264
VERSION     XP_016876264.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020775.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..487
                     /product="intraflagellar transport protein 88 homolog
                     isoform X20"
                     /calculated_mol_wt=54548
     Region          206..234
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          208..>350
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Site            order(247,250..251,253,282,285..286,289..290,292..293,315,
                     318..319,322..323,326)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          247..270
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          280..310
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          314..341
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..487
                     /gene="IFT88"
                     /gene_synonym="D13S1056E; DAF19; hTg737; TG737; TTC10"
                     /coded_by="XM_017020775.2:408..1871"
                     /db_xref="GeneID:8100"
                     /db_xref="HGNC:HGNC:20606"
                     /db_xref="MIM:600595"
ORIGIN      
        1 mkftntkvqm mqnvhlapet deddlysgyn dynpiydiee lendaafqqa vrtshgrrpp
       61 itakisstav trpiatgygs ktslassigr pmtgaiqdgv trpmtavraa gftkaalrgs
      121 afdplsqsrg paspleakkk dspeekikql ekevnelvee scianscgdl klalekakda
      181 grkervlvrq reqvttpeni nldltysvlf nlasqysvne myaealntyq vivknkmfsn
      241 agilkmnmgn iylkqrnysk aikfyrmald qvpsvnkqmr ikimqnigvt fiqagqysda
      301 insyehimsm apnlkagynl ticyfaigdr ekmkkafqkl itvpleided kyispsddph
      361 tnlvteaikn dhlrqmerer kamaekyimt sakliapvie tsfaagydwc vevvkasqyv
      421 elandleink avtylrqkdy nqaveilkvl ekkdsrvksa aatnlsalyy mdrplptrcv
      481 gcygtep
//
LOCUS       XP_024305183             396 aa            linear   PRI 05-AUG-2025
DEFINITION  intraflagellar transport protein 88 homolog isoform X21 [Homo
            sapiens].
ACCESSION   XP_024305183
VERSION     XP_024305183.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449415.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..396
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..396
                     /product="intraflagellar transport protein 88 homolog
                     isoform X21"
                     /calculated_mol_wt=44463
     Region          206..234
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          208..>350
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Site            order(247,250..251,253,282,285..286,289..290,292..293,315,
                     318..319,322..323,326)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          247..270
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          280..310
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          314..341
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..396
                     /gene="IFT88"
                     /gene_synonym="D13S1056E; DAF19; hTg737; TG737; TTC10"
                     /coded_by="XM_024449415.2:408..1598"
                     /db_xref="GeneID:8100"
                     /db_xref="HGNC:HGNC:20606"
                     /db_xref="MIM:600595"
ORIGIN      
        1 mkftntkvqm mqnvhlapet deddlysgyn dynpiydiee lendaafqqa vrtshgrrpp
       61 itakisstav trpiatgygs ktslassigr pmtgaiqdgv trpmtavraa gftkaalrgs
      121 afdplsqsrg paspleakkk dspeekikql ekevnelvee scianscgdl klalekakda
      181 grkervlvrq reqvttpeni nldltysvlf nlasqysvne myaealntyq vivknkmfsn
      241 agilkmnmgn iylkqrnysk aikfyrmald qvpsvnkqmr ikimqnigvt fiqagqysda
      301 insyehimsm apnlkagynl ticyfaigdr ekmkkafqkl itvpleided kyispsddph
      361 tnlvteaikn dhlrqmerer issqrqnsiy fissfl
//
LOCUS       XP_047286633             387 aa            linear   PRI 05-AUG-2025
DEFINITION  intraflagellar transport protein 88 homolog isoform X22 [Homo
            sapiens].
ACCESSION   XP_047286633
VERSION     XP_047286633.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430677.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..387
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..387
                     /product="intraflagellar transport protein 88 homolog
                     isoform X22"
                     /calculated_mol_wt=43385
     Region          197..225
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          199..>341
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Site            order(238,241..242,244,273,276..277,280..281,283..284,306,
                     309..310,313..314,317)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          238..261
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          271..301
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          305..332
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..387
                     /gene="IFT88"
                     /gene_synonym="D13S1056E; DAF19; hTg737; TG737; TTC10"
                     /coded_by="XM_047430677.1:107..1270"
                     /db_xref="GeneID:8100"
                     /db_xref="HGNC:HGNC:20606"
                     /db_xref="MIM:600595"
ORIGIN      
        1 mmqnvhlape tdeddlysgy ndynpiydie elendaafqq avrtshgrrp pitakissta
       61 vtrpiatgyg sktslassig rpmtgaiqdg vtrpmtavra agftkaalrg safdplsqsr
      121 gpaspleakk kdspeekikq lekevnelve escianscgd lklalekakd agrkervlvr
      181 qreqvttpen inldltysvl fnlasqysvn emyaealnty qvivknkmfs nagilkmnmg
      241 niylkqrnys kaikfyrmal dqvpsvnkqm rikimqnigv tfiqagqysd ainsyehims
      301 mapnlkagyn lticyfaigd rekmkkafqk litvpleide dkyispsddp htnlvteaik
      361 ndhlrqmere rissqrqnsi yfissfl
//
LOCUS       XP_016876265             380 aa            linear   PRI 05-AUG-2025
DEFINITION  intraflagellar transport protein 88 homolog isoform X23 [Homo
            sapiens].
ACCESSION   XP_016876265
VERSION     XP_016876265.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020776.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..380
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..380
                     /product="intraflagellar transport protein 88 homolog
                     isoform X23"
                     /calculated_mol_wt=42522
     Region          206..234
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          208..>350
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Site            order(247,250..251,253,282,285..286,289..290,292..293,315,
                     318..319,322..323,326)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          247..270
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          280..310
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          314..341
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..380
                     /gene="IFT88"
                     /gene_synonym="D13S1056E; DAF19; hTg737; TG737; TTC10"
                     /coded_by="XM_017020776.2:408..1550"
                     /db_xref="GeneID:8100"
                     /db_xref="HGNC:HGNC:20606"
                     /db_xref="MIM:600595"
ORIGIN      
        1 mkftntkvqm mqnvhlapet deddlysgyn dynpiydiee lendaafqqa vrtshgrrpp
       61 itakisstav trpiatgygs ktslassigr pmtgaiqdgv trpmtavraa gftkaalrgs
      121 afdplsqsrg paspleakkk dspeekikql ekevnelvee scianscgdl klalekakda
      181 grkervlvrq reqvttpeni nldltysvlf nlasqysvne myaealntyq vivknkmfsn
      241 agilkmnmgn iylkqrnysk aikfyrmald qvpsvnkqmr ikimqnigvt fiqagqysda
      301 insyehimsm apnlkagynl ticyfaigdr ekmkkafqkl itvpleided kyispsddph
      361 tnlvteaikn dhlrqmeres
//
LOCUS       XP_047286634             371 aa            linear   PRI 05-AUG-2025
DEFINITION  intraflagellar transport protein 88 homolog isoform X24 [Homo
            sapiens].
ACCESSION   XP_047286634
VERSION     XP_047286634.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430678.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..371
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..371
                     /product="intraflagellar transport protein 88 homolog
                     isoform X24"
                     /calculated_mol_wt=41443
     Region          197..>341
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          197..225
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(238,241..242,244,273,276..277,280..281,283..284,306,
                     309..310,313..314,317)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          238..261
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          271..301
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          305..332
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..371
                     /gene="IFT88"
                     /gene_synonym="D13S1056E; DAF19; hTg737; TG737; TTC10"
                     /coded_by="XM_047430678.1:107..1222"
                     /db_xref="GeneID:8100"
                     /db_xref="HGNC:HGNC:20606"
                     /db_xref="MIM:600595"
ORIGIN      
        1 mmqnvhlape tdeddlysgy ndynpiydie elendaafqq avrtshgrrp pitakissta
       61 vtrpiatgyg sktslassig rpmtgaiqdg vtrpmtavra agftkaalrg safdplsqsr
      121 gpaspleakk kdspeekikq lekevnelve escianscgd lklalekakd agrkervlvr
      181 qreqvttpen inldltysvl fnlasqysvn emyaealnty qvivknkmfs nagilkmnmg
      241 niylkqrnys kaikfyrmal dqvpsvnkqm rikimqnigv tfiqagqysd ainsyehims
      301 mapnlkagyn lticyfaigd rekmkkafqk litvpleide dkyispsddp htnlvteaik
      361 ndhlrqmere s
//
LOCUS       XP_047286635             346 aa            linear   PRI 05-AUG-2025
DEFINITION  intraflagellar transport protein 88 homolog isoform X25 [Homo
            sapiens].
ACCESSION   XP_047286635
VERSION     XP_047286635.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430679.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..346
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..346
                     /product="intraflagellar transport protein 88 homolog
                     isoform X25"
                     /calculated_mol_wt=38782
     Region          156..>330
                     /region_name="Spy"
                     /note="Predicted O-linked N-acetylglucosamine transferase,
                     SPINDLY family [Posttranslational modification, protein
                     turnover, chaperones]; COG3914"
                     /db_xref="CDD:443119"
     Region          206..234
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(207,210..211,214..215,217,243,246..247,250..251,
                     253..254,282,285..286,289..290,293)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          241..271
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          281..307
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..346
                     /gene="IFT88"
                     /gene_synonym="D13S1056E; DAF19; hTg737; TG737; TTC10"
                     /coded_by="XM_047430679.1:408..1448"
                     /db_xref="GeneID:8100"
                     /db_xref="HGNC:HGNC:20606"
                     /db_xref="MIM:600595"
ORIGIN      
        1 mkftntkvqm mqnvhlapet deddlysgyn dynpiydiee lendaafqqa vrtshgrrpp
       61 itakisstav trpiatgygs ktslassigr pmtgaiqdgv trpmtavraa gftkaalrgs
      121 afdplsqsrg paspleakkk dspeekikql ekevnelvee scianscgdl klalekakda
      181 grkervlvrq reqvttpeni nldltysvlf nlasqysvne myaealntyq vivknkmfsn
      241 agilkmnmgn iylkqrnysk aikfyrmald qvpsvnkqmr ikimqnigvt fiqadrekmk
      301 kafqklitvp leidedkyis psddphtnlv teaikndhlr qmeres
//
LOCUS       XP_047286637             873 aa            linear   PRI 05-AUG-2025
DEFINITION  tudor domain-containing protein 3 isoform X1 [Homo sapiens].
ACCESSION   XP_047286637
VERSION     XP_047286637.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430681.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..873
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..873
                     /product="tudor domain-containing protein 3 isoform X1"
                     /calculated_mol_wt=97309
     Region          79..229
                     /region_name="RMI1_N"
                     /note="RecQ mediated genome instability protein;
                     pfam08585"
                     /db_xref="CDD:462527"
     Region          351..389
                     /region_name="UBA_TDRD3"
                     /note="UBA domain of Tudor domain-containing protein 3
                     (TDRD3) and similar proteins; cd14282"
                     /db_xref="CDD:270468"
     Region          713..765
                     /region_name="Tudor_TDRD3"
                     /note="Tudor domain found in Tudor domain-containing
                     protein 3 (TDRD3) and similar proteins; cd20413"
                     /db_xref="CDD:410484"
     Site            order(723..725,730,748,751,753,755)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:410484"
     CDS             1..873
                     /gene="TDRD3"
                     /coded_by="XM_047430681.1:15530..18151"
                     /db_xref="GeneID:81550"
                     /db_xref="HGNC:HGNC:20612"
                     /db_xref="MIM:614392"
ORIGIN      
        1 msidgkmnke nvvytvdleq ygfelcefty twiffdfyha ttetarptpp llpppqptqh
       61 ednededlnd glfphneqyl sdegieacts spdkvnvndi ilialntdlr tigkkflpsd
      121 insgkvekle gpcvlqiqki rnvaapkdne esqaaprmlr lqmtdghisc tavefsymsk
      181 islntppgtk vklsgivdik ngflllndsn ttvlggeveh liekwelqrs lskhnrsnig
      241 teggpppfvp fgqkcvshvq vdsreldrrk tlqvtmpvkp tndndefekq rtaaiaevak
      301 sketktfggg gggarsnlnm naagnrnrev lqkekstkse gkhegvyrel vdekalkhit
      361 emgfskeasr qalmdngnnl eaalnvllts nkqkpvmgpp lrgrgkgrgr irsedeedlg
      421 narpsapstl fdfleskmgt lnveepksqp qqlhqgqyrs snteqngvkd nnhlrhpprn
      481 dtrqprnekp prfqrdsqns ksvlegsglp rnrgserpst ssvsevwaed rikcdrpysr
      541 ydrtkdtsyp lgsqhsdgaf kkrdnsmqsr sgkgpsfaea kenplpqgsv dynnqkrgkr
      601 esqtsipdyf ydrksqtinn eafsgikiek hfnvntdyqn pvrsnsfigv pngevemplk
      661 grrigpikpa gpvtavpcdd kifynsgpkr rsgpikpeki lessipmeya kmwkpgdecf
      721 alywednkfy raevealhss gmtavvkfid ygnyeevlls nikpiqteaw agkhfqtlcf
      781 ilkgfgekgs lssrgagnaq eesedlgssp gsatyylcdf grkkaptikl wssvgevmas
      841 qddplgqpns ftnhpglgtn rksrlfvkkr asd
//
LOCUS       XP_024305184             872 aa            linear   PRI 05-AUG-2025
DEFINITION  tudor domain-containing protein 3 isoform X2 [Homo sapiens].
ACCESSION   XP_024305184
VERSION     XP_024305184.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449416.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XP_024305184.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..872
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..872
                     /product="tudor domain-containing protein 3 isoform X2"
                     /calculated_mol_wt=97222
     Region          79..229
                     /region_name="RMI1_N"
                     /note="RecQ mediated genome instability protein;
                     pfam08585"
                     /db_xref="CDD:462527"
     Region          351..389
                     /region_name="UBA_TDRD3"
                     /note="UBA domain of Tudor domain-containing protein 3
                     (TDRD3) and similar proteins; cd14282"
                     /db_xref="CDD:270468"
     Region          713..765
                     /region_name="Tudor_TDRD3"
                     /note="Tudor domain found in Tudor domain-containing
                     protein 3 (TDRD3) and similar proteins; cd20413"
                     /db_xref="CDD:410484"
     Site            order(723..725,730,748,751,753,755)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:410484"
     CDS             1..872
                     /gene="TDRD3"
                     /coded_by="XM_024449416.2:15530..18148"
                     /db_xref="GeneID:81550"
                     /db_xref="HGNC:HGNC:20612"
                     /db_xref="MIM:614392"
ORIGIN      
        1 msidgkmnke nvvytvdleq ygfelcefty twiffdfyha ttetarptpp llpppqptqh
       61 ednededlnd glfphneqyl sdegieacts spdkvnvndi ilialntdlr tigkkflpsd
      121 insgkvekle gpcvlqiqki rnvaapkdne esqaaprmlr lqmtdghisc tavefsymsk
      181 islntppgtk vklsgivdik ngflllndsn ttvlggeveh liekwelqrs lskhnrsnig
      241 teggpppfvp fgqkcvshvq vdsreldrrk tlqvtmpvkp tndndefekq rtaaiaevak
      301 sketktfggg gggarsnlnm naagnrnrev lqkekstkse gkhegvyrel vdekalkhit
      361 emgfskeasr qalmdngnnl eaalnvllts nkqkpvmgpp lrgrgkgrgr irsedeedlg
      421 narpsapstl fdfleskmgt lnveepksqp qqlhqgqyrs snteqngvkd nnhlrhpprn
      481 dtrqprnekp prfqrdsqns ksvlegsglp rnrgserpst ssvsevwaed rikcdrpysr
      541 ydrtkdtsyp lgsqhsdgaf kkrdnsmqsr sgkgpsfaea kenplpqgsv dynnqkrgkr
      601 esqtsipdyf ydrksqtinn eafsgikiek hfnvntdyqn pvrsnsfigv pngevemplk
      661 grrigpikpa gpvtavpcdd kifynsgpkr rsgpikpeki lessipmeya kmwkpgdecf
      721 alywednkfy raevealhss gmtavvkfid ygnyeevlls nikpiqteaw agkhfqtlcf
      781 ilkgfgekgs lssrgagnaq eesedlgssp gsatyylcdf grkkaptikl wssvgevmas
      841 qddplgqpns ftnhpglgtn rkrlfvkkra sd
//
LOCUS       XP_005266613             809 aa            linear   PRI 05-AUG-2025
DEFINITION  tudor domain-containing protein 3 isoform X3 [Homo sapiens].
ACCESSION   XP_005266613
VERSION     XP_005266613.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266556.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..809
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..809
                     /product="tudor domain-containing protein 3 isoform X3"
                     /calculated_mol_wt=89501
     Region          15..165
                     /region_name="RMI1_N"
                     /note="RecQ mediated genome instability protein;
                     pfam08585"
                     /db_xref="CDD:462527"
     Region          287..325
                     /region_name="UBA_TDRD3"
                     /note="UBA domain of Tudor domain-containing protein 3
                     (TDRD3) and similar proteins; cd14282"
                     /db_xref="CDD:270468"
     Region          649..701
                     /region_name="Tudor_TDRD3"
                     /note="Tudor domain found in Tudor domain-containing
                     protein 3 (TDRD3) and similar proteins; cd20413"
                     /db_xref="CDD:410484"
     Site            order(659..661,666,684,687,689,691)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:410484"
     CDS             1..809
                     /gene="TDRD3"
                     /coded_by="XM_005266556.5:146..2575"
                     /db_xref="GeneID:81550"
                     /db_xref="HGNC:HGNC:20612"
                     /db_xref="MIM:614392"
ORIGIN      
        1 maqvagaals qagwylsdeg ieactsspdk vnvndiilia lntdlrtigk kflpsdinsg
       61 kveklegpcv lqiqkirnva apkdneesqa aprmlrlqmt dghisctave fsymskisln
      121 tppgtkvkls givdikngfl llndsnttvl ggevehliek welqrslskh nrsnigtegg
      181 pppfvpfgqk cvshvqvdsr eldrrktlqv tmpvkptndn defekqrtaa iaevaksket
      241 ktfgggggga rsnlnmnaag nrnrevlqke kstksegkhe gvyrelvdek alkhitemgf
      301 skeasrqalm dngnnleaal nvlltsnkqk pvmgpplrgr gkgrgrirse deedlgnarp
      361 sapstlfdfl eskmgtlnve epksqpqqlh qgqyrssnte qngvkdnnhl rhpprndtrq
      421 prnekpprfq rdsqnsksvl egsglprnrg serpstssvs evwaedrikc drpysrydrt
      481 kdtsyplgsq hsdgafkkrd nsmqsrsgkg psfaeakenp lpqgsvdynn qkrgkresqt
      541 sipdyfydrk sqtinneafs gikiekhfnv ntdyqnpvrs nsfigvpnge vemplkgrri
      601 gpikpagpvt avpcddkify nsgpkrrsgp ikpekiless ipmeyakmwk pgdecfalyw
      661 ednkfyraev ealhssgmta vvkfidygny eevllsnikp iqteawagkh fqtlcfilkg
      721 fgekgslssr gagnaqeese dlgsspgsat yylcdfgrkk aptiklwssv gevmasqddp
      781 lgqpnsftnh pglgtnrksr lfvkkrasd
//
LOCUS       XP_047286638             808 aa            linear   PRI 05-AUG-2025
DEFINITION  tudor domain-containing protein 3 isoform X4 [Homo sapiens].
ACCESSION   XP_047286638
VERSION     XP_047286638.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430682.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..808
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..808
                     /product="tudor domain-containing protein 3 isoform X4"
                     /calculated_mol_wt=89414
     Region          15..165
                     /region_name="RMI1_N"
                     /note="RecQ mediated genome instability protein;
                     pfam08585"
                     /db_xref="CDD:462527"
     Region          287..325
                     /region_name="UBA_TDRD3"
                     /note="UBA domain of Tudor domain-containing protein 3
                     (TDRD3) and similar proteins; cd14282"
                     /db_xref="CDD:270468"
     Region          649..701
                     /region_name="Tudor_TDRD3"
                     /note="Tudor domain found in Tudor domain-containing
                     protein 3 (TDRD3) and similar proteins; cd20413"
                     /db_xref="CDD:410484"
     Site            order(659..661,666,684,687,689,691)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:410484"
     CDS             1..808
                     /gene="TDRD3"
                     /coded_by="XM_047430682.1:146..2572"
                     /db_xref="GeneID:81550"
                     /db_xref="HGNC:HGNC:20612"
                     /db_xref="MIM:614392"
ORIGIN      
        1 maqvagaals qagwylsdeg ieactsspdk vnvndiilia lntdlrtigk kflpsdinsg
       61 kveklegpcv lqiqkirnva apkdneesqa aprmlrlqmt dghisctave fsymskisln
      121 tppgtkvkls givdikngfl llndsnttvl ggevehliek welqrslskh nrsnigtegg
      181 pppfvpfgqk cvshvqvdsr eldrrktlqv tmpvkptndn defekqrtaa iaevaksket
      241 ktfgggggga rsnlnmnaag nrnrevlqke kstksegkhe gvyrelvdek alkhitemgf
      301 skeasrqalm dngnnleaal nvlltsnkqk pvmgpplrgr gkgrgrirse deedlgnarp
      361 sapstlfdfl eskmgtlnve epksqpqqlh qgqyrssnte qngvkdnnhl rhpprndtrq
      421 prnekpprfq rdsqnsksvl egsglprnrg serpstssvs evwaedrikc drpysrydrt
      481 kdtsyplgsq hsdgafkkrd nsmqsrsgkg psfaeakenp lpqgsvdynn qkrgkresqt
      541 sipdyfydrk sqtinneafs gikiekhfnv ntdyqnpvrs nsfigvpnge vemplkgrri
      601 gpikpagpvt avpcddkify nsgpkrrsgp ikpekiless ipmeyakmwk pgdecfalyw
      661 ednkfyraev ealhssgmta vvkfidygny eevllsnikp iqteawagkh fqtlcfilkg
      721 fgekgslssr gagnaqeese dlgsspgsat yylcdfgrkk aptiklwssv gevmasqddp
      781 lgqpnsftnh pglgtnrkrl fvkkrasd
//
LOCUS       XP_047286639             808 aa            linear   PRI 05-AUG-2025
DEFINITION  tudor domain-containing protein 3 isoform X5 [Homo sapiens].
ACCESSION   XP_047286639
VERSION     XP_047286639.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430683.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..808
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..808
                     /product="tudor domain-containing protein 3 isoform X5"
                     /calculated_mol_wt=90781
     Region          79..229
                     /region_name="RMI1_N"
                     /note="RecQ mediated genome instability protein;
                     pfam08585"
                     /db_xref="CDD:462527"
     Region          351..389
                     /region_name="UBA_TDRD3"
                     /note="UBA domain of Tudor domain-containing protein 3
                     (TDRD3) and similar proteins; cd14282"
                     /db_xref="CDD:270468"
     Region          680..>804
                     /region_name="SMN"
                     /note="Survival motor neuron protein (SMN); pfam06003"
                     /db_xref="CDD:428716"
     Region          713..765
                     /region_name="Tudor_TDRD3"
                     /note="Tudor domain found in Tudor domain-containing
                     protein 3 (TDRD3) and similar proteins; cd20413"
                     /db_xref="CDD:410484"
     Site            order(723..725,730,748,751,753,755)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:410484"
     CDS             1..808
                     /gene="TDRD3"
                     /coded_by="XM_047430683.1:15530..17956"
                     /db_xref="GeneID:81550"
                     /db_xref="HGNC:HGNC:20612"
                     /db_xref="MIM:614392"
ORIGIN      
        1 msidgkmnke nvvytvdleq ygfelcefty twiffdfyha ttetarptpp llpppqptqh
       61 ednededlnd glfphneqyl sdegieacts spdkvnvndi ilialntdlr tigkkflpsd
      121 insgkvekle gpcvlqiqki rnvaapkdne esqaaprmlr lqmtdghisc tavefsymsk
      181 islntppgtk vklsgivdik ngflllndsn ttvlggeveh liekwelqrs lskhnrsnig
      241 teggpppfvp fgqkcvshvq vdsreldrrk tlqvtmpvkp tndndefekq rtaaiaevak
      301 sketktfggg gggarsnlnm naagnrnrev lqkekstkse gkhegvyrel vdekalkhit
      361 emgfskeasr qalmdngnnl eaalnvllts nkqkpvmgpp lrgrgkgrgr irsedeedlg
      421 narpsapstl fdfleskmgt lnveepksqp qqlhqgqyrs snteqngvkd nnhlrhpprn
      481 dtrqprnekp prfqrdsqns ksvlegsglp rnrgserpst ssvsevwaed rikcdrpysr
      541 ydrtkdtsyp lgsqhsdgaf kkrdnsmqsr sgkgpsfaea kenplpqgsv dynnqkrgkr
      601 esqtsipdyf ydrksqtinn eafsgikiek hfnvntdyqn pvrsnsfigv pngevemplk
      661 grrigpikpa gpvtavpcdd kifynsgpkr rsgpikpeki lessipmeya kmwkpgdecf
      721 alywednkfy raevealhss gmtavvkfid ygnyeevlls nikpiqteaw eeegtydqtl
      781 efrrggdgqp rrstrptqqf yqpprarn
//
LOCUS       XP_047286640             807 aa            linear   PRI 05-AUG-2025
DEFINITION  tudor domain-containing protein 3 isoform X6 [Homo sapiens].
ACCESSION   XP_047286640
VERSION     XP_047286640.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430684.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..807
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..807
                     /product="tudor domain-containing protein 3 isoform X6"
                     /calculated_mol_wt=89579
     Region          13..163
                     /region_name="RMI1_N"
                     /note="RecQ mediated genome instability protein;
                     pfam08585"
                     /db_xref="CDD:462527"
     Region          285..323
                     /region_name="UBA_TDRD3"
                     /note="UBA domain of Tudor domain-containing protein 3
                     (TDRD3) and similar proteins; cd14282"
                     /db_xref="CDD:270468"
     Region          647..699
                     /region_name="Tudor_TDRD3"
                     /note="Tudor domain found in Tudor domain-containing
                     protein 3 (TDRD3) and similar proteins; cd20413"
                     /db_xref="CDD:410484"
     Site            order(657..659,664,682,685,687,689)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:410484"
     CDS             1..807
                     /gene="TDRD3"
                     /coded_by="XM_047430684.1:423..2846"
                     /db_xref="GeneID:81550"
                     /db_xref="HGNC:HGNC:20612"
                     /db_xref="MIM:614392"
ORIGIN      
        1 mfgvgfarvi wrylsdegie actsspdkvn vndiilialn tdlrtigkkf lpsdinsgkv
       61 eklegpcvlq iqkirnvaap kdneesqaap rmlrlqmtdg hisctavefs ymskislntp
      121 pgtkvklsgi vdikngflll ndsnttvlgg evehliekwe lqrslskhnr snigteggpp
      181 pfvpfgqkcv shvqvdsrel drrktlqvtm pvkptndnde fekqrtaaia evaksketkt
      241 fggggggars nlnmnaagnr nrevlqkeks tksegkhegv yrelvdekal khitemgfsk
      301 easrqalmdn gnnleaalnv lltsnkqkpv mgpplrgrgk grgrirsede edlgnarpsa
      361 pstlfdfles kmgtlnveep ksqpqqlhqg qyrssnteqn gvkdnnhlrh pprndtrqpr
      421 nekpprfqrd sqnsksvleg sglprnrgse rpstssvsev waedrikcdr pysrydrtkd
      481 tsyplgsqhs dgafkkrdns mqsrsgkgps faeakenplp qgsvdynnqk rgkresqtsi
      541 pdyfydrksq tinneafsgi kiekhfnvnt dyqnpvrsns figvpngeve mplkgrrigp
      601 ikpagpvtav pcddkifyns gpkrrsgpik pekilessip meyakmwkpg decfalywed
      661 nkfyraevea lhssgmtavv kfidygnyee vllsnikpiq teawagkhfq tlcfilkgfg
      721 ekgslssrga gnaqeesedl gsspgsatyy lcdfgrkkap tiklwssvge vmasqddplg
      781 qpnsftnhpg lgtnrksrlf vkkrasd
//
LOCUS       XP_047286641             778 aa            linear   PRI 05-AUG-2025
DEFINITION  tudor domain-containing protein 3 isoform X7 [Homo sapiens].
ACCESSION   XP_047286641
VERSION     XP_047286641.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430685.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..778
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..778
                     /product="tudor domain-containing protein 3 isoform X7"
                     /calculated_mol_wt=87265
     Region          42..199
                     /region_name="RMI1_N"
                     /note="RecQ mediated genome instability protein;
                     pfam08585"
                     /db_xref="CDD:462527"
     Region          321..359
                     /region_name="UBA_TDRD3"
                     /note="UBA domain of Tudor domain-containing protein 3
                     (TDRD3) and similar proteins; cd14282"
                     /db_xref="CDD:270468"
     Region          683..735
                     /region_name="Tudor_TDRD3"
                     /note="Tudor domain found in Tudor domain-containing
                     protein 3 (TDRD3) and similar proteins; cd20413"
                     /db_xref="CDD:410484"
     Site            order(693..695,700,718,721,723,725)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:410484"
     CDS             1..778
                     /gene="TDRD3"
                     /coded_by="XM_047430685.1:705..3041"
                     /db_xref="GeneID:81550"
                     /db_xref="HGNC:HGNC:20612"
                     /db_xref="MIM:614392"
ORIGIN      
        1 mgtlplrslf prntgrrrge rprrwskllg saswarvpfr lflsdwpayl sdegieacts
       61 spdkvnvndi ilialntdlr tigkkflpsd insgkvekle gpcvlqiqki rnvaapkdne
      121 esqaaprmlr lqmtdghisc tavefsymsk islntppgtk vklsgivdik ngflllndsn
      181 ttvlggeveh liekwelqrs lskhnrsnig teggpppfvp fgqkcvshvq vdsreldrrk
      241 tlqvtmpvkp tndndefekq rtaaiaevak sketktfggg gggarsnlnm naagnrnrev
      301 lqkekstkse gkhegvyrel vdekalkhit emgfskeasr qalmdngnnl eaalnvllts
      361 nkqkpvmgpp lrgrgkgrgr irsedeedlg narpsapstl fdfleskmgt lnveepksqp
      421 qqlhqgqyrs snteqngvkd nnhlrhpprn dtrqprnekp prfqrdsqns ksvlegsglp
      481 rnrgserpst ssvsevwaed rikcdrpysr ydrtkdtsyp lgsqhsdgaf kkrdnsmqsr
      541 sgkgpsfaea kenplpqgsv dynnqkrgkr esqtsipdyf ydrksqtinn eafsgikiek
      601 hfnvntdyqn pvrsnsfigv pngevemplk grrigpikpa gpvtavpcdd kifynsgpkr
      661 rsgpikpeki lessipmeya kmwkpgdecf alywednkfy raevealhss gmtavvkfid
      721 ygnyeevlls nikpiqteaw eeegtydqtl efrrggdgqp rrstrptqqf yqpprarn
//
LOCUS       XP_024305185             716 aa            linear   PRI 05-AUG-2025
DEFINITION  tudor domain-containing protein 3 isoform X8 [Homo sapiens].
ACCESSION   XP_024305185
VERSION     XP_024305185.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449417.2
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 1% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..716
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..716
                     /product="tudor domain-containing protein 3 isoform X8"
                     /calculated_mol_wt=79582
     Region          <1..72
                     /region_name="RMI1_N"
                     /note="RecQ mediated genome instability protein;
                     pfam08585"
                     /db_xref="CDD:462527"
     Region          194..232
                     /region_name="UBA_TDRD3"
                     /note="UBA domain of Tudor domain-containing protein 3
                     (TDRD3) and similar proteins; cd14282"
                     /db_xref="CDD:270468"
     Region          556..608
                     /region_name="Tudor_TDRD3"
                     /note="Tudor domain found in Tudor domain-containing
                     protein 3 (TDRD3) and similar proteins; cd20413"
                     /db_xref="CDD:410484"
     Site            order(566..568,573,591,594,596,598)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:410484"
     CDS             1..716
                     /gene="TDRD3"
                     /coded_by="XM_024449417.2:793..2943"
                     /db_xref="GeneID:81550"
                     /db_xref="HGNC:HGNC:20612"
                     /db_xref="MIM:614392"
ORIGIN      
        1 mlrlqmtdgh isctavefsy mskislntpp gtkvklsgiv dikngfllln dsnttvlgge
       61 vehliekwel qrslskhnrs nigteggppp fvpfgqkcvs hvqvdsreld rrktlqvtmp
      121 vkptndndef ekqrtaaiae vaksketktf ggggggarsn lnmnaagnrn revlqkekst
      181 ksegkhegvy relvdekalk hitemgfske asrqalmdng nnleaalnvl ltsnkqkpvm
      241 gpplrgrgkg rgrirsedee dlgnarpsap stlfdflesk mgtlnveepk sqpqqlhqgq
      301 yrssnteqng vkdnnhlrhp prndtrqprn ekpprfqrds qnsksvlegs glprnrgser
      361 pstssvsevw aedrikcdrp ysrydrtkdt syplgsqhsd gafkkrdnsm qsrsgkgpsf
      421 aeakenplpq gsvdynnqkr gkresqtsip dyfydrksqt inneafsgik iekhfnvntd
      481 yqnpvrsnsf igvpngevem plkgrrigpi kpagpvtavp cddkifynsg pkrrsgpikp
      541 ekilessipm eyakmwkpgd ecfalywedn kfyraeveal hssgmtavvk fidygnyeev
      601 llsnikpiqt eawagkhfqt lcfilkgfge kgslssrgag naqeesedlg sspgsatyyl
      661 cdfgrkkapt iklwssvgev masqddplgq pnsftnhpgl gtnrksrlfv kkrasd
//
LOCUS       XP_005266617             716 aa            linear   PRI 05-AUG-2025
DEFINITION  tudor domain-containing protein 3 isoform X8 [Homo sapiens].
ACCESSION   XP_005266617
VERSION     XP_005266617.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266560.3
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 1% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..716
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..716
                     /product="tudor domain-containing protein 3 isoform X8"
                     /calculated_mol_wt=79582
     Region          <1..72
                     /region_name="RMI1_N"
                     /note="RecQ mediated genome instability protein;
                     pfam08585"
                     /db_xref="CDD:462527"
     Region          194..232
                     /region_name="UBA_TDRD3"
                     /note="UBA domain of Tudor domain-containing protein 3
                     (TDRD3) and similar proteins; cd14282"
                     /db_xref="CDD:270468"
     Region          556..608
                     /region_name="Tudor_TDRD3"
                     /note="Tudor domain found in Tudor domain-containing
                     protein 3 (TDRD3) and similar proteins; cd20413"
                     /db_xref="CDD:410484"
     Site            order(566..568,573,591,594,596,598)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:410484"
     CDS             1..716
                     /gene="TDRD3"
                     /coded_by="XM_005266560.3:789..2939"
                     /db_xref="GeneID:81550"
                     /db_xref="HGNC:HGNC:20612"
                     /db_xref="MIM:614392"
ORIGIN      
        1 mlrlqmtdgh isctavefsy mskislntpp gtkvklsgiv dikngfllln dsnttvlgge
       61 vehliekwel qrslskhnrs nigteggppp fvpfgqkcvs hvqvdsreld rrktlqvtmp
      121 vkptndndef ekqrtaaiae vaksketktf ggggggarsn lnmnaagnrn revlqkekst
      181 ksegkhegvy relvdekalk hitemgfske asrqalmdng nnleaalnvl ltsnkqkpvm
      241 gpplrgrgkg rgrirsedee dlgnarpsap stlfdflesk mgtlnveepk sqpqqlhqgq
      301 yrssnteqng vkdnnhlrhp prndtrqprn ekpprfqrds qnsksvlegs glprnrgser
      361 pstssvsevw aedrikcdrp ysrydrtkdt syplgsqhsd gafkkrdnsm qsrsgkgpsf
      421 aeakenplpq gsvdynnqkr gkresqtsip dyfydrksqt inneafsgik iekhfnvntd
      481 yqnpvrsnsf igvpngevem plkgrrigpi kpagpvtavp cddkifynsg pkrrsgpikp
      541 ekilessipm eyakmwkpgd ecfalywedn kfyraeveal hssgmtavvk fidygnyeev
      601 llsnikpiqt eawagkhfqt lcfilkgfge kgslssrgag naqeesedlg sspgsatyyl
      661 cdfgrkkapt iklwssvgev masqddplgq pnsftnhpgl gtnrksrlfv kkrasd
//
LOCUS       XP_047286643             498 aa            linear   PRI 05-AUG-2025
DEFINITION  tudor domain-containing protein 3 isoform X9 [Homo sapiens].
ACCESSION   XP_047286643
VERSION     XP_047286643.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430687.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..498
                     /product="tudor domain-containing protein 3 isoform X9"
                     /calculated_mol_wt=55086
     Region          79..229
                     /region_name="RMI1_N"
                     /note="RecQ mediated genome instability protein;
                     pfam08585"
                     /db_xref="CDD:462527"
     Region          351..389
                     /region_name="UBA_TDRD3"
                     /note="UBA domain of Tudor domain-containing protein 3
                     (TDRD3) and similar proteins; cd14282"
                     /db_xref="CDD:270468"
     CDS             1..498
                     /gene="TDRD3"
                     /coded_by="XM_047430687.1:15530..17026"
                     /db_xref="GeneID:81550"
                     /db_xref="HGNC:HGNC:20612"
                     /db_xref="MIM:614392"
ORIGIN      
        1 msidgkmnke nvvytvdleq ygfelcefty twiffdfyha ttetarptpp llpppqptqh
       61 ednededlnd glfphneqyl sdegieacts spdkvnvndi ilialntdlr tigkkflpsd
      121 insgkvekle gpcvlqiqki rnvaapkdne esqaaprmlr lqmtdghisc tavefsymsk
      181 islntppgtk vklsgivdik ngflllndsn ttvlggeveh liekwelqrs lskhnrsnig
      241 teggpppfvp fgqkcvshvq vdsreldrrk tlqvtmpvkp tndndefekq rtaaiaevak
      301 sketktfggg gggarsnlnm naagnrnrev lqkekstkse gkhegvyrel vdekalkhit
      361 emgfskeasr qalmdngnnl eaalnvllts nkqkpvmgpp lrgrgkgrgr irsedeedlg
      421 narpsapstl fdfleskmgt lnvevnflat egtvspkmsv ealfgsvtlg kyknnyscml
      481 immydkgnkt htpktnet
//
LOCUS       XP_047286644             434 aa            linear   PRI 05-AUG-2025
DEFINITION  tudor domain-containing protein 3 isoform X10 [Homo sapiens].
ACCESSION   XP_047286644
VERSION     XP_047286644.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430688.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..434
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..434
                     /product="tudor domain-containing protein 3 isoform X10"
                     /calculated_mol_wt=47278
     Region          15..165
                     /region_name="RMI1_N"
                     /note="RecQ mediated genome instability protein;
                     pfam08585"
                     /db_xref="CDD:462527"
     Region          287..325
                     /region_name="UBA_TDRD3"
                     /note="UBA domain of Tudor domain-containing protein 3
                     (TDRD3) and similar proteins; cd14282"
                     /db_xref="CDD:270468"
     CDS             1..434
                     /gene="TDRD3"
                     /coded_by="XM_047430688.1:146..1450"
                     /db_xref="GeneID:81550"
                     /db_xref="HGNC:HGNC:20612"
                     /db_xref="MIM:614392"
ORIGIN      
        1 maqvagaals qagwylsdeg ieactsspdk vnvndiilia lntdlrtigk kflpsdinsg
       61 kveklegpcv lqiqkirnva apkdneesqa aprmlrlqmt dghisctave fsymskisln
      121 tppgtkvkls givdikngfl llndsnttvl ggevehliek welqrslskh nrsnigtegg
      181 pppfvpfgqk cvshvqvdsr eldrrktlqv tmpvkptndn defekqrtaa iaevaksket
      241 ktfgggggga rsnlnmnaag nrnrevlqke kstksegkhe gvyrelvdek alkhitemgf
      301 skeasrqalm dngnnleaal nvlltsnkqk pvmgpplrgr gkgrgrirse deedlgnarp
      361 sapstlfdfl eskmgtlnve vnflategtv spkmsvealf gsvtlgkykn nyscmlimmy
      421 dkgnkthtpk tnet
//
LOCUS       XP_011533552             528 aa            linear   PRI 05-AUG-2025
DEFINITION  cytidine and dCMP deaminase domain-containing protein 1 isoform X1
            [Homo sapiens].
ACCESSION   XP_011533552
VERSION     XP_011533552.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535250.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..528
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..528
                     /product="cytidine and dCMP deaminase domain-containing
                     protein 1 isoform X1"
                     /calculated_mol_wt=59998
     Region          93..165
                     /region_name="cytidine_deaminase-like"
                     /note="Cytidine and deoxycytidylate deaminase zinc-binding
                     region. The family contains cytidine deaminases,
                     nucleoside deaminases, deoxycytidylate deaminases and
                     riboflavin deaminases. Also included are the apoBec family
                     of mRNA editing enzymes. All members...; cl00269"
                     /db_xref="CDD:444801"
     Site            order(123..125,147..148,151)
                     /site_type="active"
                     /db_xref="CDD:238406"
     Site            order(123,125,148,151)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:238406"
     Region          333..468
                     /region_name="deoxycytidylate_deaminase"
                     /note="Deoxycytidylate deaminase domain. Deoxycytidylate
                     deaminase catalyzes the deamination of dCMP to dUMP,
                     providing the nucleotide substrate for thymidylate
                     synthase. The enzyme binds Zn++, which is required for
                     catalytic activity. The activity of the...; cd01286"
                     /db_xref="CDD:238613"
     Site            order(374,412,414,439..440,443)
                     /site_type="active"
                     /note="catalytic motif [active]"
                     /db_xref="CDD:238613"
     Site            order(412,414,440,443)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:238613"
     CDS             1..528
                     /gene="CDADC1"
                     /gene_synonym="bA103J18.1; NYD-SP15"
                     /coded_by="XM_011535250.3:3..1589"
                     /db_xref="GeneID:81602"
                     /db_xref="HGNC:HGNC:20299"
                     /db_xref="MIM:618997"
ORIGIN      
        1 mrrlftacfg lspsamcisc tvfscrvrag errlnflsge ggqiprlskv nlftllslwm
       61 elfpaeaqrq ksqkneegkh gplgdneert rvstdkrqvk rtglvvvknm kivglhcsse
      121 dlhagqiali khgsrlkncd lyfsrkpcsa clkmivnagv nrisywpadp eisllteass
      181 sedakldaka verlksnsra hvcvllqplv cymvqfveet sykcdfiqki tktlpdantd
      241 fyyeckqeri keyemlflvs neemhkqilm tiglenlcen pyfsnlrqnm kdlilllatv
      301 assvpnfkhf gfyrsnpeqi neihnqslpq eiarhcmvqa rllayrtedh ktgvgaviwa
      361 egksrscdgt gamyfvgcgy nafpvgseya dfphmddkqk dreirkfryi ihaeqnaltf
      421 rcqeikpeer smifvtkcpc decvplikga gikqiyagdv dvgkkkadis ymrfgelegv
      481 skftwqlnps gaygleqnep errengvlrp vpqkeeqhqd kklrlgih
//
LOCUS       XP_047286645             396 aa            linear   PRI 05-AUG-2025
DEFINITION  cytidine and dCMP deaminase domain-containing protein 1 isoform X2
            [Homo sapiens].
ACCESSION   XP_047286645
VERSION     XP_047286645.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430689.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..396
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..396
                     /product="cytidine and dCMP deaminase domain-containing
                     protein 1 isoform X2"
                     /calculated_mol_wt=45280
     Region          <15..46
                     /region_name="ComEB"
                     /note="Deoxycytidylate deaminase [Nucleotide transport and
                     metabolism]; COG2131"
                     /db_xref="CDD:441734"
     Region          201..336
                     /region_name="deoxycytidylate_deaminase"
                     /note="Deoxycytidylate deaminase domain. Deoxycytidylate
                     deaminase catalyzes the deamination of dCMP to dUMP,
                     providing the nucleotide substrate for thymidylate
                     synthase. The enzyme binds Zn++, which is required for
                     catalytic activity. The activity of the...; cd01286"
                     /db_xref="CDD:238613"
     Site            order(242,280,282,307..308,311)
                     /site_type="active"
                     /note="catalytic motif [active]"
                     /db_xref="CDD:238613"
     Site            order(280,282,308,311)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:238613"
     CDS             1..396
                     /gene="CDADC1"
                     /gene_synonym="bA103J18.1; NYD-SP15"
                     /coded_by="XM_047430689.1:133..1323"
                     /db_xref="GeneID:81602"
                     /db_xref="HGNC:HGNC:20299"
                     /db_xref="MIM:618997"
ORIGIN      
        1 mkrgpeyllt kdrkpcsacl kmivnagvnr isywpadpei sllteassse dakldakave
       61 rlksnsrahv cvllqplvcy mvqfveetsy kcdfiqkitk tlpdantdfy yeckqerike
      121 yemlflvsne emhkqilmti glenlcenpy fsnlrqnmkd lilllatvas svpnfkhfgf
      181 yrsnpeqine ihnqslpqei arhcmvqarl layrtedhkt gvgaviwaeg ksrscdgtga
      241 myfvgcgyna fpvgseyadf phmddkqkdr eirkfryiih aeqnaltfrc qeikpeersm
      301 ifvtkcpcde cvplikgagi kqiyagdvdv gkkkadisym rfgelegvsk ftwqlnpsga
      361 ygleqneper rengvlrpvp qkeeqhqdkk lrlgih
//
LOCUS       XP_006719934             375 aa            linear   PRI 05-AUG-2025
DEFINITION  cytidine and dCMP deaminase domain-containing protein 1 isoform X3
            [Homo sapiens].
ACCESSION   XP_006719934
VERSION     XP_006719934.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006719871.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..375
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..375
                     /product="cytidine and dCMP deaminase domain-containing
                     protein 1 isoform X3"
                     /calculated_mol_wt=42884
     Region          180..315
                     /region_name="deoxycytidylate_deaminase"
                     /note="Deoxycytidylate deaminase domain. Deoxycytidylate
                     deaminase catalyzes the deamination of dCMP to dUMP,
                     providing the nucleotide substrate for thymidylate
                     synthase. The enzyme binds Zn++, which is required for
                     catalytic activity. The activity of the...; cd01286"
                     /db_xref="CDD:238613"
     Site            order(221,259,261,286..287,290)
                     /site_type="active"
                     /note="catalytic motif [active]"
                     /db_xref="CDD:238613"
     Site            order(259,261,287,290)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:238613"
     CDS             1..375
                     /gene="CDADC1"
                     /gene_synonym="bA103J18.1; NYD-SP15"
                     /coded_by="XM_006719871.4:275..1402"
                     /db_xref="GeneID:81602"
                     /db_xref="HGNC:HGNC:20299"
                     /db_xref="MIM:618997"
ORIGIN      
        1 mhgragvnri sywpadpeis llteasssed akldakaver lksnsrahvc vllqplvcym
       61 vqfveetsyk cdfiqkitkt lpdantdfyy eckqerikey emlflvsnee mhkqilmtig
      121 lenlcenpyf snlrqnmkdl illlatvass vpnfkhfgfy rsnpeqinei hnqslpqeia
      181 rhcmvqarll ayrtedhktg vgaviwaegk srscdgtgam yfvgcgynaf pvgseyadfp
      241 hmddkqkdre irkfryiiha eqnaltfrcq eikpeersmi fvtkcpcdec vplikgagik
      301 qiyagdvdvg kkkadisymr fgelegvskf twqlnpsgay gleqneperr engvlrpvpq
      361 keeqhqdkkl rlgih
//
LOCUS       XP_047286646             316 aa            linear   PRI 05-AUG-2025
DEFINITION  cytidine and dCMP deaminase domain-containing protein 1 isoform X4
            [Homo sapiens].
ACCESSION   XP_047286646
VERSION     XP_047286646.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430690.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..316
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..316
                     /product="cytidine and dCMP deaminase domain-containing
                     protein 1 isoform X4"
                     /calculated_mol_wt=36405
     Region          121..256
                     /region_name="deoxycytidylate_deaminase"
                     /note="Deoxycytidylate deaminase domain. Deoxycytidylate
                     deaminase catalyzes the deamination of dCMP to dUMP,
                     providing the nucleotide substrate for thymidylate
                     synthase. The enzyme binds Zn++, which is required for
                     catalytic activity. The activity of the...; cd01286"
                     /db_xref="CDD:238613"
     Site            order(162,200,202,227..228,231)
                     /site_type="active"
                     /note="catalytic motif [active]"
                     /db_xref="CDD:238613"
     Site            order(200,202,228,231)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:238613"
     CDS             1..316
                     /gene="CDADC1"
                     /gene_synonym="bA103J18.1; NYD-SP15"
                     /coded_by="XM_047430690.1:258..1208"
                     /db_xref="GeneID:81602"
                     /db_xref="HGNC:HGNC:20299"
                     /db_xref="MIM:618997"
ORIGIN      
        1 mvqfveetsy kcdfiqkitk tlpdantdfy yeckqerike yemlflvsne emhkqilmti
       61 glenlcenpy fsnlrqnmkd lilllatvas svpnfkhfgf yrsnpeqine ihnqslpqei
      121 arhcmvqarl layrtedhkt gvgaviwaeg ksrscdgtga myfvgcgyna fpvgseyadf
      181 phmddkqkdr eirkfryiih aeqnaltfrc qeikpeersm ifvtkcpcde cvplikgagi
      241 kqiyagdvdv gkkkadisym rfgelegvsk ftwqlnpsga ygleqneper rengvlrpvp
      301 qkeeqhqdkk lrlgih
//
LOCUS       XP_047286648             316 aa            linear   PRI 05-AUG-2025
DEFINITION  cytidine and dCMP deaminase domain-containing protein 1 isoform X4
            [Homo sapiens].
ACCESSION   XP_047286648
VERSION     XP_047286648.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430692.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..316
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..316
                     /product="cytidine and dCMP deaminase domain-containing
                     protein 1 isoform X4"
                     /calculated_mol_wt=36405
     Region          121..256
                     /region_name="deoxycytidylate_deaminase"
                     /note="Deoxycytidylate deaminase domain. Deoxycytidylate
                     deaminase catalyzes the deamination of dCMP to dUMP,
                     providing the nucleotide substrate for thymidylate
                     synthase. The enzyme binds Zn++, which is required for
                     catalytic activity. The activity of the...; cd01286"
                     /db_xref="CDD:238613"
     Site            order(162,200,202,227..228,231)
                     /site_type="active"
                     /note="catalytic motif [active]"
                     /db_xref="CDD:238613"
     Site            order(200,202,228,231)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:238613"
     CDS             1..316
                     /gene="CDADC1"
                     /gene_synonym="bA103J18.1; NYD-SP15"
                     /coded_by="XM_047430692.1:255..1205"
                     /db_xref="GeneID:81602"
                     /db_xref="HGNC:HGNC:20299"
                     /db_xref="MIM:618997"
ORIGIN      
        1 mvqfveetsy kcdfiqkitk tlpdantdfy yeckqerike yemlflvsne emhkqilmti
       61 glenlcenpy fsnlrqnmkd lilllatvas svpnfkhfgf yrsnpeqine ihnqslpqei
      121 arhcmvqarl layrtedhkt gvgaviwaeg ksrscdgtga myfvgcgyna fpvgseyadf
      181 phmddkqkdr eirkfryiih aeqnaltfrc qeikpeersm ifvtkcpcde cvplikgagi
      241 kqiyagdvdv gkkkadisym rfgelegvsk ftwqlnpsga ygleqneper rengvlrpvp
      301 qkeeqhqdkk lrlgih
//
LOCUS       XP_011533553             469 aa            linear   PRI 05-AUG-2025
DEFINITION  cytidine and dCMP deaminase domain-containing protein 1 isoform X5
            [Homo sapiens].
ACCESSION   XP_011533553
VERSION     XP_011533553.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535251.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..469
                     /product="cytidine and dCMP deaminase domain-containing
                     protein 1 isoform X5"
                     /calculated_mol_wt=53417
     Region          34..106
                     /region_name="cytidine_deaminase-like"
                     /note="Cytidine and deoxycytidylate deaminase zinc-binding
                     region. The family contains cytidine deaminases,
                     nucleoside deaminases, deoxycytidylate deaminases and
                     riboflavin deaminases. Also included are the apoBec family
                     of mRNA editing enzymes. All members...; cl00269"
                     /db_xref="CDD:444801"
     Site            order(64..66,88..89,92)
                     /site_type="active"
                     /db_xref="CDD:238406"
     Site            order(64,66,89,92)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:238406"
     Region          274..409
                     /region_name="deoxycytidylate_deaminase"
                     /note="Deoxycytidylate deaminase domain. Deoxycytidylate
                     deaminase catalyzes the deamination of dCMP to dUMP,
                     providing the nucleotide substrate for thymidylate
                     synthase. The enzyme binds Zn++, which is required for
                     catalytic activity. The activity of the...; cd01286"
                     /db_xref="CDD:238613"
     Site            order(315,353,355,380..381,384)
                     /site_type="active"
                     /note="catalytic motif [active]"
                     /db_xref="CDD:238613"
     Site            order(353,355,381,384)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:238613"
     CDS             1..469
                     /gene="CDADC1"
                     /gene_synonym="bA103J18.1; NYD-SP15"
                     /coded_by="XM_011535251.2:127..1536"
                     /db_xref="GeneID:81602"
                     /db_xref="HGNC:HGNC:20299"
                     /db_xref="MIM:618997"
ORIGIN      
        1 melfpaeaqr qksqkneegk hgplgdneer trvstdkrqv krtglvvvkn mkivglhcss
       61 edlhagqial ikhgsrlknc dlyfsrkpcs aclkmivnag vnrisywpad peisllteas
      121 ssedakldak averlksnsr ahvcvllqpl vcymvqfvee tsykcdfiqk itktlpdant
      181 dfyyeckqer ikeyemlflv sneemhkqil mtiglenlce npyfsnlrqn mkdlilllat
      241 vassvpnfkh fgfyrsnpeq ineihnqslp qeiarhcmvq arllayrted hktgvgaviw
      301 aegksrscdg tgamyfvgcg ynafpvgsey adfphmddkq kdreirkfry iihaeqnalt
      361 frcqeikpee rsmifvtkcp cdecvplikg agikqiyagd vdvgkkkadi symrfgeleg
      421 vskftwqlnp sgaygleqne perrengvlr pvpqkeeqhq dkklrlgih
//
LOCUS       XP_047286649             337 aa            linear   PRI 05-AUG-2025
DEFINITION  calcium-binding protein 39-like isoform X1 [Homo sapiens].
ACCESSION   XP_047286649
VERSION     XP_047286649.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430693.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..337
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..337
                     /product="calcium-binding protein 39-like isoform X1"
                     /calculated_mol_wt=38957
     Region          6..333
                     /region_name="Mo25"
                     /note="Mo25-like; pfam08569"
                     /db_xref="CDD:462522"
     CDS             1..337
                     /gene="CAB39L"
                     /gene_synonym="bA103J18.3; MLAA-34; MO25-BETA; MO2L"
                     /coded_by="XM_047430693.1:1013..2026"
                     /db_xref="GeneID:81617"
                     /db_xref="HGNC:HGNC:20290"
                     /db_xref="MIM:612175"
ORIGIN      
        1 mkkmplfsks hknpaeivki lkdnlailek qdkktdkase evskslqamk eilcgtneke
       61 ppteavaqla qelyssgllv tliadlqlid fegkkdvtqi fnnilrrqig trsptveyis
      121 ahphilfmll kgyeapqial rcgimlreci rheplakiil fsnqfrdffk yvelstfdia
      181 sdafatfkdl ltrhkvlvad fleqnydtif edyekllqse nyvtkrqslk llgelildrh
      241 nfaimtkyis kpenlklmmn llrdkspniq feafhvfkvf vasphktqpi veillknqpk
      301 lieflssfqk ertddeqfad eknylikqir dlkktap
//
LOCUS       XP_047286650             337 aa            linear   PRI 05-AUG-2025
DEFINITION  calcium-binding protein 39-like isoform X1 [Homo sapiens].
ACCESSION   XP_047286650
VERSION     XP_047286650.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430694.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..337
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..337
                     /product="calcium-binding protein 39-like isoform X1"
                     /calculated_mol_wt=38957
     Region          6..333
                     /region_name="Mo25"
                     /note="Mo25-like; pfam08569"
                     /db_xref="CDD:462522"
     CDS             1..337
                     /gene="CAB39L"
                     /gene_synonym="bA103J18.3; MLAA-34; MO25-BETA; MO2L"
                     /coded_by="XM_047430694.1:751..1764"
                     /db_xref="GeneID:81617"
                     /db_xref="HGNC:HGNC:20290"
                     /db_xref="MIM:612175"
ORIGIN      
        1 mkkmplfsks hknpaeivki lkdnlailek qdkktdkase evskslqamk eilcgtneke
       61 ppteavaqla qelyssgllv tliadlqlid fegkkdvtqi fnnilrrqig trsptveyis
      121 ahphilfmll kgyeapqial rcgimlreci rheplakiil fsnqfrdffk yvelstfdia
      181 sdafatfkdl ltrhkvlvad fleqnydtif edyekllqse nyvtkrqslk llgelildrh
      241 nfaimtkyis kpenlklmmn llrdkspniq feafhvfkvf vasphktqpi veillknqpk
      301 lieflssfqk ertddeqfad eknylikqir dlkktap
//
LOCUS       XP_047286651             337 aa            linear   PRI 05-AUG-2025
DEFINITION  calcium-binding protein 39-like isoform X1 [Homo sapiens].
ACCESSION   XP_047286651
VERSION     XP_047286651.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430695.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..337
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..337
                     /product="calcium-binding protein 39-like isoform X1"
                     /calculated_mol_wt=38957
     Region          6..333
                     /region_name="Mo25"
                     /note="Mo25-like; pfam08569"
                     /db_xref="CDD:462522"
     CDS             1..337
                     /gene="CAB39L"
                     /gene_synonym="bA103J18.3; MLAA-34; MO25-BETA; MO2L"
                     /coded_by="XM_047430695.1:760..1773"
                     /db_xref="GeneID:81617"
                     /db_xref="HGNC:HGNC:20290"
                     /db_xref="MIM:612175"
ORIGIN      
        1 mkkmplfsks hknpaeivki lkdnlailek qdkktdkase evskslqamk eilcgtneke
       61 ppteavaqla qelyssgllv tliadlqlid fegkkdvtqi fnnilrrqig trsptveyis
      121 ahphilfmll kgyeapqial rcgimlreci rheplakiil fsnqfrdffk yvelstfdia
      181 sdafatfkdl ltrhkvlvad fleqnydtif edyekllqse nyvtkrqslk llgelildrh
      241 nfaimtkyis kpenlklmmn llrdkspniq feafhvfkvf vasphktqpi veillknqpk
      301 lieflssfqk ertddeqfad eknylikqir dlkktap
//
LOCUS       XP_047286652             337 aa            linear   PRI 05-AUG-2025
DEFINITION  calcium-binding protein 39-like isoform X1 [Homo sapiens].
ACCESSION   XP_047286652
VERSION     XP_047286652.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430696.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..337
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..337
                     /product="calcium-binding protein 39-like isoform X1"
                     /calculated_mol_wt=38957
     Region          6..333
                     /region_name="Mo25"
                     /note="Mo25-like; pfam08569"
                     /db_xref="CDD:462522"
     CDS             1..337
                     /gene="CAB39L"
                     /gene_synonym="bA103J18.3; MLAA-34; MO25-BETA; MO2L"
                     /coded_by="XM_047430696.1:496..1509"
                     /db_xref="GeneID:81617"
                     /db_xref="HGNC:HGNC:20290"
                     /db_xref="MIM:612175"
ORIGIN      
        1 mkkmplfsks hknpaeivki lkdnlailek qdkktdkase evskslqamk eilcgtneke
       61 ppteavaqla qelyssgllv tliadlqlid fegkkdvtqi fnnilrrqig trsptveyis
      121 ahphilfmll kgyeapqial rcgimlreci rheplakiil fsnqfrdffk yvelstfdia
      181 sdafatfkdl ltrhkvlvad fleqnydtif edyekllqse nyvtkrqslk llgelildrh
      241 nfaimtkyis kpenlklmmn llrdkspniq feafhvfkvf vasphktqpi veillknqpk
      301 lieflssfqk ertddeqfad eknylikqir dlkktap
//
LOCUS       XP_047286653             337 aa            linear   PRI 05-AUG-2025
DEFINITION  calcium-binding protein 39-like isoform X1 [Homo sapiens].
ACCESSION   XP_047286653
VERSION     XP_047286653.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430697.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..337
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..337
                     /product="calcium-binding protein 39-like isoform X1"
                     /calculated_mol_wt=38957
     Region          6..333
                     /region_name="Mo25"
                     /note="Mo25-like; pfam08569"
                     /db_xref="CDD:462522"
     CDS             1..337
                     /gene="CAB39L"
                     /gene_synonym="bA103J18.3; MLAA-34; MO25-BETA; MO2L"
                     /coded_by="XM_047430697.1:567..1580"
                     /db_xref="GeneID:81617"
                     /db_xref="HGNC:HGNC:20290"
                     /db_xref="MIM:612175"
ORIGIN      
        1 mkkmplfsks hknpaeivki lkdnlailek qdkktdkase evskslqamk eilcgtneke
       61 ppteavaqla qelyssgllv tliadlqlid fegkkdvtqi fnnilrrqig trsptveyis
      121 ahphilfmll kgyeapqial rcgimlreci rheplakiil fsnqfrdffk yvelstfdia
      181 sdafatfkdl ltrhkvlvad fleqnydtif edyekllqse nyvtkrqslk llgelildrh
      241 nfaimtkyis kpenlklmmn llrdkspniq feafhvfkvf vasphktqpi veillknqpk
      301 lieflssfqk ertddeqfad eknylikqir dlkktap
//
LOCUS       XP_047286654             337 aa            linear   PRI 05-AUG-2025
DEFINITION  calcium-binding protein 39-like isoform X1 [Homo sapiens].
ACCESSION   XP_047286654
VERSION     XP_047286654.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430698.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..337
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..337
                     /product="calcium-binding protein 39-like isoform X1"
                     /calculated_mol_wt=38957
     Region          6..333
                     /region_name="Mo25"
                     /note="Mo25-like; pfam08569"
                     /db_xref="CDD:462522"
     CDS             1..337
                     /gene="CAB39L"
                     /gene_synonym="bA103J18.3; MLAA-34; MO25-BETA; MO2L"
                     /coded_by="XM_047430698.1:429..1442"
                     /db_xref="GeneID:81617"
                     /db_xref="HGNC:HGNC:20290"
                     /db_xref="MIM:612175"
ORIGIN      
        1 mkkmplfsks hknpaeivki lkdnlailek qdkktdkase evskslqamk eilcgtneke
       61 ppteavaqla qelyssgllv tliadlqlid fegkkdvtqi fnnilrrqig trsptveyis
      121 ahphilfmll kgyeapqial rcgimlreci rheplakiil fsnqfrdffk yvelstfdia
      181 sdafatfkdl ltrhkvlvad fleqnydtif edyekllqse nyvtkrqslk llgelildrh
      241 nfaimtkyis kpenlklmmn llrdkspniq feafhvfkvf vasphktqpi veillknqpk
      301 lieflssfqk ertddeqfad eknylikqir dlkktap
//
LOCUS       XP_047286655             337 aa            linear   PRI 05-AUG-2025
DEFINITION  calcium-binding protein 39-like isoform X1 [Homo sapiens].
ACCESSION   XP_047286655
VERSION     XP_047286655.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430699.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..337
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..337
                     /product="calcium-binding protein 39-like isoform X1"
                     /calculated_mol_wt=38957
     Region          6..333
                     /region_name="Mo25"
                     /note="Mo25-like; pfam08569"
                     /db_xref="CDD:462522"
     CDS             1..337
                     /gene="CAB39L"
                     /gene_synonym="bA103J18.3; MLAA-34; MO25-BETA; MO2L"
                     /coded_by="XM_047430699.1:889..1902"
                     /db_xref="GeneID:81617"
                     /db_xref="HGNC:HGNC:20290"
                     /db_xref="MIM:612175"
ORIGIN      
        1 mkkmplfsks hknpaeivki lkdnlailek qdkktdkase evskslqamk eilcgtneke
       61 ppteavaqla qelyssgllv tliadlqlid fegkkdvtqi fnnilrrqig trsptveyis
      121 ahphilfmll kgyeapqial rcgimlreci rheplakiil fsnqfrdffk yvelstfdia
      181 sdafatfkdl ltrhkvlvad fleqnydtif edyekllqse nyvtkrqslk llgelildrh
      241 nfaimtkyis kpenlklmmn llrdkspniq feafhvfkvf vasphktqpi veillknqpk
      301 lieflssfqk ertddeqfad eknylikqir dlkktap
//
LOCUS       XP_024305190            1143 aa            linear   PRI 05-AUG-2025
DEFINITION  protein diaphanous homolog 3 isoform X1 [Homo sapiens].
ACCESSION   XP_024305190
VERSION     XP_024305190.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449422.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1143
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1143
                     /product="protein diaphanous homolog 3 isoform X1"
                     /calculated_mol_wt=131626
     Region          114..297
                     /region_name="Drf_GBD"
                     /note="Diaphanous GTPase-binding Domain; pfam06371"
                     /db_xref="CDD:461886"
     Region          305..488
                     /region_name="Drf_FH3"
                     /note="Diaphanous FH3 Domain; pfam06367"
                     /db_xref="CDD:461885"
     Region          499..>552
                     /region_name="CwlO1"
                     /note="Uncharacterized N-terminal coiled-coil domain of
                     peptidoglycan hydrolase CwlO [Function unknown]; COG3883"
                     /db_xref="CDD:443091"
     Region          636..1008
                     /region_name="FH2"
                     /note="Formin Homology 2 Domain; pfam02181"
                     /db_xref="CDD:396655"
     CDS             1..1143
                     /gene="DIAPH3"
                     /gene_synonym="AN; AUNA1; DIA2; diap3; DRF3; mDia2; NSDAN"
                     /coded_by="XM_024449422.1:163..3594"
                     /db_xref="GeneID:81624"
                     /db_xref="HGNC:HGNC:15480"
                     /db_xref="MIM:614567"
ORIGIN      
        1 merhqprlhh paqgsaagtp ypssaslrgc reskmprrkg pqhppppsgp eepgekrpkf
       61 hlnirtltdd mldkfasiri pgskkerppl pnlktafass dcsaaplemm enfpkplsen
      121 ellelfekmm edmnlnedkk aplrekdfsi kkemvmqyin tasktgslkr srqispqefi
      181 helkmgsade rlvtcleslr vsltsnpvsw vesfgheglg llldilekli sgkiqekvvk
      241 knqhkviqcl kalmntqygl erimseersl sllakavdpr hpnmmtdvvk llsavcivge
      301 esileevlea ltsageekki drffcivegl rhnsvqlqva cmqlinalvt spddldfrlh
      361 irnefmrcgl keilpnlkci kndgldiqlk vfdehkeedl felshrledi raeldeaydv
      421 ynmvwstvke traegyfisi lqhlllirnd yfirqqyfkl idecvsqivl hrdgmdpdft
      481 yrkrldldlt qfvdicidqa kleefeekas elykkfekef tdhqetqael qkkeakinel
      541 qaelqafksq fgalpadcni plppskeggt ghsalppppp lpsgggvppp pppppppplp
      601 gmrmpfsgpv ppppplgflg gqnspplpil pfglkpkkef kpeismrrln wlkirphemt
      661 encfwikvne nkyenvdllc klentfccqq kerreeedie ekksikkkik elkfldskia
      721 qnlsiflssf rvpyeeirmm ilevdetrla esmiqnlikh lpdqeqlnsl sqfkseysnl
      781 cepeqfvvvm snvkrlrprl sailfklqfe eqvnnikpdi mavstaceei kksksfskll
      841 elvllmgnym nagsrnaqtf gfnlsslckl kdtksadqkt tllhflveic eekypdilnf
      901 vddlepldka skvsvetlek nlrqmgrqlq qlekeletfp ppedlhdkfv tkmsrfvisa
      961 keqyetlskl henmeklyqs iigyyaidvk kvsvedfltd lnnfrttfmq aikenikkre
     1021 aeekekrvri akelaererl erqqkkkrll emktegdetg vmdnllealq sgaafrdrrk
     1081 rtpmpkdvrq slspmsqrpv lkvcnheekq cpfrreefeq egdtpytnrn rdlqlrnvfs
     1141 tee
//
LOCUS       XP_011533560            1136 aa            linear   PRI 05-AUG-2025
DEFINITION  protein diaphanous homolog 3 isoform X2 [Homo sapiens].
ACCESSION   XP_011533560
VERSION     XP_011533560.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535258.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1136
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1136
                     /product="protein diaphanous homolog 3 isoform X2"
                     /calculated_mol_wt=130312
     Region          114..297
                     /region_name="Drf_GBD"
                     /note="Diaphanous GTPase-binding Domain; pfam06371"
                     /db_xref="CDD:461886"
     Region          305..488
                     /region_name="Drf_FH3"
                     /note="Diaphanous FH3 Domain; pfam06367"
                     /db_xref="CDD:461885"
     Region          499..>552
                     /region_name="CwlO1"
                     /note="Uncharacterized N-terminal coiled-coil domain of
                     peptidoglycan hydrolase CwlO [Function unknown]; COG3883"
                     /db_xref="CDD:443091"
     Region          636..1008
                     /region_name="FH2"
                     /note="Formin Homology 2 Domain; pfam02181"
                     /db_xref="CDD:396655"
     CDS             1..1136
                     /gene="DIAPH3"
                     /gene_synonym="AN; AUNA1; DIA2; diap3; DRF3; mDia2; NSDAN"
                     /coded_by="XM_011535258.3:163..3573"
                     /db_xref="GeneID:81624"
                     /db_xref="HGNC:HGNC:15480"
                     /db_xref="MIM:614567"
ORIGIN      
        1 merhqprlhh paqgsaagtp ypssaslrgc reskmprrkg pqhppppsgp eepgekrpkf
       61 hlnirtltdd mldkfasiri pgskkerppl pnlktafass dcsaaplemm enfpkplsen
      121 ellelfekmm edmnlnedkk aplrekdfsi kkemvmqyin tasktgslkr srqispqefi
      181 helkmgsade rlvtcleslr vsltsnpvsw vesfgheglg llldilekli sgkiqekvvk
      241 knqhkviqcl kalmntqygl erimseersl sllakavdpr hpnmmtdvvk llsavcivge
      301 esileevlea ltsageekki drffcivegl rhnsvqlqva cmqlinalvt spddldfrlh
      361 irnefmrcgl keilpnlkci kndgldiqlk vfdehkeedl felshrledi raeldeaydv
      421 ynmvwstvke traegyfisi lqhlllirnd yfirqqyfkl idecvsqivl hrdgmdpdft
      481 yrkrldldlt qfvdicidqa kleefeekas elykkfekef tdhqetqael qkkeakinel
      541 qaelqafksq fgalpadcni plppskeggt ghsalppppp lpsgggvppp pppppppplp
      601 gmrmpfsgpv ppppplgflg gqnspplpil pfglkpkkef kpeismrrln wlkirphemt
      661 encfwikvne nkyenvdllc klentfccqq kerreeedie ekksikkkik elkfldskia
      721 qnlsiflssf rvpyeeirmm ilevdetrla esmiqnlikh lpdqeqlnsl sqfkseysnl
      781 cepeqfvvvm snvkrlrprl sailfklqfe eqvnnikpdi mavstaceei kksksfskll
      841 elvllmgnym nagsrnaqtf gfnlsslckl kdtksadqkt tllhflveic eekypdilnf
      901 vddlepldka skvsvetlek nlrqmgrqlq qlekeletfp ppedlhdkfv tkmsrfvisa
      961 keqyetlskl henmeklyqs iigyyaidvk kvsvedfltd lnnfrttfmq aikenikkre
     1021 aeekekrvri akelaererl erqqkkkrll emktegdetg vmdnllealq sgaafrdrrk
     1081 rtpmpkdvrq slspmsqrpv lkvcnhetgg apkpkaprrq tgsrslrkqs lltrea
//
LOCUS       XP_006719939             930 aa            linear   PRI 05-AUG-2025
DEFINITION  protein diaphanous homolog 3 isoform X3 [Homo sapiens].
ACCESSION   XP_006719939
VERSION     XP_006719939.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006719876.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..930
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..930
                     /product="protein diaphanous homolog 3 isoform X3"
                     /calculated_mol_wt=107080
     Region          <1..34
                     /region_name="Drf_GBD"
                     /note="Diaphanous GTPase-binding Domain; pfam06371"
                     /db_xref="CDD:461886"
     Region          42..225
                     /region_name="Drf_FH3"
                     /note="Diaphanous FH3 Domain; pfam06367"
                     /db_xref="CDD:461885"
     Region          236..>289
                     /region_name="CwlO1"
                     /note="Uncharacterized N-terminal coiled-coil domain of
                     peptidoglycan hydrolase CwlO [Function unknown]; COG3883"
                     /db_xref="CDD:443091"
     Region          373..745
                     /region_name="FH2"
                     /note="Formin Homology 2 Domain; pfam02181"
                     /db_xref="CDD:396655"
     CDS             1..930
                     /gene="DIAPH3"
                     /gene_synonym="AN; AUNA1; DIA2; diap3; DRF3; mDia2; NSDAN"
                     /coded_by="XM_006719876.1:160..2952"
                     /db_xref="GeneID:81624"
                     /db_xref="HGNC:HGNC:15480"
                     /db_xref="MIM:614567"
ORIGIN      
        1 mseerslsll akavdprhpn mmtdvvklls avcivgeesi leevlealts ageekkidrf
       61 fciveglrhn svqlqvacmq linalvtspd dldfrlhirn efmrcglkei lpnlkciknd
      121 gldiqlkvfd ehkeedlfel shrledirae ldeaydvynm vwstvketra egyfisilqh
      181 lllirndyfi rqqyfklide cvsqivlhrd gmdpdftyrk rldldltqfv dicidqakle
      241 efeekasely kkfekeftdh qetqaelqkk eakinelqae lqafksqfga lpadcniplp
      301 pskeggtghs alppppplps gggvpppppp ppppplpgmr mpfsgpvppp pplgflggqn
      361 spplpilpfg lkpkkefkpe ismrrlnwlk irphemtenc fwikvnenky envdllckle
      421 ntfccqqker reeedieekk sikkkikelk fldskiaqnl siflssfrvp yeeirmmile
      481 vdetrlaesm iqnlikhlpd qeqlnslsqf kseysnlcep eqfvvvmsnv krlrprlsai
      541 lfklqfeeqv nnikpdimav staceeikks ksfskllelv llmgnymnag srnaqtfgfn
      601 lsslcklkdt ksadqkttll hflveiceek ypdilnfvdd lepldkaskv svetleknlr
      661 qmgrqlqqle keletfpppe dlhdkfvtkm srfvisakeq yetlsklhen meklyqsiig
      721 yyaidvkkvs vedfltdlnn frttfmqaik enikkreaee kekrvriake laererlerq
      781 qkkkrllemk tegdetgvmd nllealqsga afrdrrkrtp mpkdvrqsls pmsqrpvlkv
      841 cnhenqkvql tegsrshyni ncnstrtpva kelnynldth tstgrikaae kkeacnvesn
      901 rkketellgs fsknesvpev eallarlral
//
LOCUS       XP_011533565             737 aa            linear   PRI 05-AUG-2025
DEFINITION  protein diaphanous homolog 3 isoform X4 [Homo sapiens].
ACCESSION   XP_011533565
VERSION     XP_011533565.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535263.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..737
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..737
                     /product="protein diaphanous homolog 3 isoform X4"
                     /calculated_mol_wt=84093
     Region          114..297
                     /region_name="Drf_GBD"
                     /note="Diaphanous GTPase-binding Domain; pfam06371"
                     /db_xref="CDD:461886"
     Region          305..488
                     /region_name="Drf_FH3"
                     /note="Diaphanous FH3 Domain; pfam06367"
                     /db_xref="CDD:461885"
     Region          499..>552
                     /region_name="CwlO1"
                     /note="Uncharacterized N-terminal coiled-coil domain of
                     peptidoglycan hydrolase CwlO [Function unknown]; COG3883"
                     /db_xref="CDD:443091"
     Region          636..>691
                     /region_name="FH2"
                     /note="Formin Homology 2 Domain; cl19758"
                     /db_xref="CDD:418645"
     CDS             1..737
                     /gene="DIAPH3"
                     /gene_synonym="AN; AUNA1; DIA2; diap3; DRF3; mDia2; NSDAN"
                     /coded_by="XM_011535263.3:163..2376"
                     /db_xref="GeneID:81624"
                     /db_xref="HGNC:HGNC:15480"
                     /db_xref="MIM:614567"
ORIGIN      
        1 merhqprlhh paqgsaagtp ypssaslrgc reskmprrkg pqhppppsgp eepgekrpkf
       61 hlnirtltdd mldkfasiri pgskkerppl pnlktafass dcsaaplemm enfpkplsen
      121 ellelfekmm edmnlnedkk aplrekdfsi kkemvmqyin tasktgslkr srqispqefi
      181 helkmgsade rlvtcleslr vsltsnpvsw vesfgheglg llldilekli sgkiqekvvk
      241 knqhkviqcl kalmntqygl erimseersl sllakavdpr hpnmmtdvvk llsavcivge
      301 esileevlea ltsageekki drffcivegl rhnsvqlqva cmqlinalvt spddldfrlh
      361 irnefmrcgl keilpnlkci kndgldiqlk vfdehkeedl felshrledi raeldeaydv
      421 ynmvwstvke traegyfisi lqhlllirnd yfirqqyfkl idecvsqivl hrdgmdpdft
      481 yrkrldldlt qfvdicidqa kleefeekas elykkfekef tdhqetqael qkkeakinel
      541 qaelqafksq fgalpadcni plppskeggt ghsalppppp lpsgggvppp pppppppplp
      601 gmrmpfsgpv ppppplgflg gqnspplpil pfglkpkkef kpeismrrln wlkirphemt
      661 encfwikvne nkyenvdllc klentfccqq kdwkhllvnf yrllengley tnrllvldls
      721 skininyfhy sqtvnrd
//
LOCUS       XP_047286657             726 aa            linear   PRI 05-AUG-2025
DEFINITION  protein diaphanous homolog 3 isoform X5 [Homo sapiens].
ACCESSION   XP_047286657
VERSION     XP_047286657.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430701.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..726
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..726
                     /product="protein diaphanous homolog 3 isoform X5"
                     /calculated_mol_wt=82783
     Region          103..286
                     /region_name="Drf_GBD"
                     /note="Diaphanous GTPase-binding Domain; pfam06371"
                     /db_xref="CDD:461886"
     Region          294..477
                     /region_name="Drf_FH3"
                     /note="Diaphanous FH3 Domain; pfam06367"
                     /db_xref="CDD:461885"
     Region          488..>541
                     /region_name="CwlO1"
                     /note="Uncharacterized N-terminal coiled-coil domain of
                     peptidoglycan hydrolase CwlO [Function unknown]; COG3883"
                     /db_xref="CDD:443091"
     Region          625..>680
                     /region_name="FH2"
                     /note="Formin Homology 2 Domain; cl19758"
                     /db_xref="CDD:418645"
     CDS             1..726
                     /gene="DIAPH3"
                     /gene_synonym="AN; AUNA1; DIA2; diap3; DRF3; mDia2; NSDAN"
                     /coded_by="XM_047430701.1:163..2343"
                     /db_xref="GeneID:81624"
                     /db_xref="HGNC:HGNC:15480"
                     /db_xref="MIM:614567"
ORIGIN      
        1 merhqprlhh paqgsaagtp ypssaslrgc reskmprrkg pqhppppsgp eepgekrpkf
       61 ldkfasirip gskkerpplp nlktafassd csaaplemme nfpkplsene llelfekmme
      121 dmnlnedkka plrekdfsik kemvmqyint asktgslkrs rqispqefih elkmgsader
      181 lvtcleslrv sltsnpvswv esfgheglgl lldileklis gkiqekvvkk nqhkviqclk
      241 almntqygle rimseersls llakavdprh pnmmtdvvkl lsavcivgee sileevleal
      301 tsageekkid rffciveglr hnsvqlqvac mqlinalvts pddldfrlhi rnefmrcglk
      361 eilpnlkcik ndgldiqlkv fdehkeedlf elshrledir aeldeaydvy nmvwstvket
      421 raegyfisil qhlllirndy firqqyfkli decvsqivlh rdgmdpdfty rkrldldltq
      481 fvdicidqak leefeekase lykkfekeft dhqetqaelq kkeakinelq aelqafksqf
      541 galpadcnip lppskeggtg hsalpppppl psgggvpppp ppppppplpg mrmpfsgpvp
      601 pppplgflgg qnspplpilp fglkpkkefk peismrrlnw lkirphemte ncfwikvnen
      661 kyenvdllck lentfccqqk dwkhllvnfy rllengleyt nrllvldlss kininyfhys
      721 qtvnrd
//
LOCUS       XP_011533567             713 aa            linear   PRI 05-AUG-2025
DEFINITION  protein diaphanous homolog 3 isoform X6 [Homo sapiens].
ACCESSION   XP_011533567
VERSION     XP_011533567.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535265.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..713
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..713
                     /product="protein diaphanous homolog 3 isoform X6"
                     /calculated_mol_wt=80732
     Region          114..297
                     /region_name="Drf_GBD"
                     /note="Diaphanous GTPase-binding Domain; pfam06371"
                     /db_xref="CDD:461886"
     Region          305..488
                     /region_name="Drf_FH3"
                     /note="Diaphanous FH3 Domain; pfam06367"
                     /db_xref="CDD:461885"
     Region          499..>552
                     /region_name="CwlO1"
                     /note="Uncharacterized N-terminal coiled-coil domain of
                     peptidoglycan hydrolase CwlO [Function unknown]; COG3883"
                     /db_xref="CDD:443091"
     Region          636..>691
                     /region_name="FH2"
                     /note="Formin Homology 2 Domain; cl19758"
                     /db_xref="CDD:418645"
     CDS             1..713
                     /gene="DIAPH3"
                     /gene_synonym="AN; AUNA1; DIA2; diap3; DRF3; mDia2; NSDAN"
                     /coded_by="XM_011535265.3:163..2304"
                     /db_xref="GeneID:81624"
                     /db_xref="HGNC:HGNC:15480"
                     /db_xref="MIM:614567"
ORIGIN      
        1 merhqprlhh paqgsaagtp ypssaslrgc reskmprrkg pqhppppsgp eepgekrpkf
       61 hlnirtltdd mldkfasiri pgskkerppl pnlktafass dcsaaplemm enfpkplsen
      121 ellelfekmm edmnlnedkk aplrekdfsi kkemvmqyin tasktgslkr srqispqefi
      181 helkmgsade rlvtcleslr vsltsnpvsw vesfgheglg llldilekli sgkiqekvvk
      241 knqhkviqcl kalmntqygl erimseersl sllakavdpr hpnmmtdvvk llsavcivge
      301 esileevlea ltsageekki drffcivegl rhnsvqlqva cmqlinalvt spddldfrlh
      361 irnefmrcgl keilpnlkci kndgldiqlk vfdehkeedl felshrledi raeldeaydv
      421 ynmvwstvke traegyfisi lqhlllirnd yfirqqyfkl idecvsqivl hrdgmdpdft
      481 yrkrldldlt qfvdicidqa kleefeekas elykkfekef tdhqetqael qkkeakinel
      541 qaelqafksq fgalpadcni plppskeggt ghsalppppp lpsgggvppp pppppppplp
      601 gmrmpfsgpv ppppplgflg gqnspplpil pfglkpkkef kpeismrrln wlkirphemt
      661 encfwikvne nkyenvdllc klentfccqq kvddisrgnt ksgeaqgcds epc
//
LOCUS       XP_016876278             706 aa            linear   PRI 05-AUG-2025
DEFINITION  protein diaphanous homolog 3 isoform X7 [Homo sapiens].
ACCESSION   XP_016876278
VERSION     XP_016876278.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020789.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..706
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..706
                     /product="protein diaphanous homolog 3 isoform X7"
                     /calculated_mol_wt=80069
     Region          114..297
                     /region_name="Drf_GBD"
                     /note="Diaphanous GTPase-binding Domain; pfam06371"
                     /db_xref="CDD:461886"
     Region          305..488
                     /region_name="Drf_FH3"
                     /note="Diaphanous FH3 Domain; pfam06367"
                     /db_xref="CDD:461885"
     Region          499..>552
                     /region_name="CwlO1"
                     /note="Uncharacterized N-terminal coiled-coil domain of
                     peptidoglycan hydrolase CwlO [Function unknown]; COG3883"
                     /db_xref="CDD:443091"
     Region          636..>697
                     /region_name="FH2"
                     /note="Formin Homology 2 Domain; cl19758"
                     /db_xref="CDD:418645"
     CDS             1..706
                     /gene="DIAPH3"
                     /gene_synonym="AN; AUNA1; DIA2; diap3; DRF3; mDia2; NSDAN"
                     /coded_by="XM_017020789.1:163..2283"
                     /db_xref="GeneID:81624"
                     /db_xref="HGNC:HGNC:15480"
                     /db_xref="MIM:614567"
ORIGIN      
        1 merhqprlhh paqgsaagtp ypssaslrgc reskmprrkg pqhppppsgp eepgekrpkf
       61 hlnirtltdd mldkfasiri pgskkerppl pnlktafass dcsaaplemm enfpkplsen
      121 ellelfekmm edmnlnedkk aplrekdfsi kkemvmqyin tasktgslkr srqispqefi
      181 helkmgsade rlvtcleslr vsltsnpvsw vesfgheglg llldilekli sgkiqekvvk
      241 knqhkviqcl kalmntqygl erimseersl sllakavdpr hpnmmtdvvk llsavcivge
      301 esileevlea ltsageekki drffcivegl rhnsvqlqva cmqlinalvt spddldfrlh
      361 irnefmrcgl keilpnlkci kndgldiqlk vfdehkeedl felshrledi raeldeaydv
      421 ynmvwstvke traegyfisi lqhlllirnd yfirqqyfkl idecvsqivl hrdgmdpdft
      481 yrkrldldlt qfvdicidqa kleefeekas elykkfekef tdhqetqael qkkeakinel
      541 qaelqafksq fgalpadcni plppskeggt ghsalppppp lpsgggvppp pppppppplp
      601 gmrmpfsgpv ppppplgflg gqnspplpil pfglkpkkef kpeismrrln wlkirphemt
      661 encfwikvne nkyenvdllc klentfccqq kgssaslypf vhilti
//
LOCUS       XP_047286658             672 aa            linear   PRI 05-AUG-2025
DEFINITION  conserved oligomeric Golgi complex subunit 3 isoform X1 [Homo
            sapiens].
ACCESSION   XP_047286658
VERSION     XP_047286658.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430702.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..672
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..672
                     /product="conserved oligomeric Golgi complex subunit 3
                     isoform X1"
                     /calculated_mol_wt=75666
     Region          131..274
                     /region_name="Sec34"
                     /note="Sec34-like family; pfam04136"
                     /db_xref="CDD:461190"
     CDS             1..672
                     /gene="COG3"
                     /gene_synonym="CDG2BB; SEC34"
                     /coded_by="XM_047430702.1:99..2117"
                     /db_xref="GeneID:83548"
                     /db_xref="HGNC:HGNC:18619"
                     /db_xref="MIM:606975"
ORIGIN      
        1 maeaallllp eaaaerdare klalwdrrpd ttapltdrqt dsvlelkaaa enlpvpaelp
       61 iedlcsltsq slpieltsvv pestedillk gftslgmeee rietaqqffs wfaklqtqmd
      121 qdegtkyrqm rdylsgfqeq cdailndvns alqhleslqk qylfvsnktg tlheaceqll
      181 keqselvdla eniqqklsyf neletintkl nsptlsvnsd gfipmlakld dcityisshp
      241 nfkdypiyll kfkqclskal hlmktytvnt lqtltsqllk rdpssvpnad naftlfyvkf
      301 raaapkvrtl ieqielrsek ipeyqqllnd ihqcyldqre lllgpsiact vaeltsqnnr
      361 dhcalvrsgc afmvhvcqde hqlynefftk ptskldelle klcvslydvf rpliihvihl
      421 etlselcgil knevledhvq nnaeqlgafa agvkqmledv qerlvyrthi yiqtditgyk
      481 papgdlaypd klvmmeqiaq slkdeqkkvp seasfsdvhl eegesnsltk sgsteslnpr
      541 pqttispadl hgmwyptvrr tlvclsklyr cidravfqgl sqealsaciq sllgasesis
      601 knktqidgql flikhllilr eqiapfhtef tikeisldlk ktrgfsvknn gqsgrpqvys
      661 ltaalgttsk gq
//
LOCUS       XP_024305191             490 aa            linear   PRI 05-AUG-2025
DEFINITION  katanin p60 ATPase-containing subunit A-like 1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_024305191
VERSION     XP_024305191.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449423.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..490
                     /product="katanin p60 ATPase-containing subunit A-like 1
                     isoform X1"
                     /calculated_mol_wt=55261
     Region          4..72
                     /region_name="Kp60-NTD"
                     /note="N-terminal domain (NTD) found in katanin p60 (Kp60)
                     ATPase-containing subunit A1, and similar proteins;
                     cd21748"
                     /db_xref="CDD:439297"
     Site            order(7,14,17..20,22,29,51,55,58..59,61..62,65..66,68..69,
                     72)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:439297"
     Region          209..378
                     /region_name="RecA-like_KTNA1"
                     /note="Katanin p60 ATPase-containing subunit A1; cd19522"
                     /db_xref="CDD:410930"
     Site            order(210..213,250..256)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:410930"
     Region          402..446
                     /region_name="AAA_lid_3"
                     /note="AAA+ lid domain; pfam17862"
                     /db_xref="CDD:465537"
     Region          <450..488
                     /region_name="Vps4_C"
                     /note="Vps4 C terminal oligomerization domain; pfam09336"
                     /db_xref="CDD:462762"
     CDS             1..490
                     /gene="KATNAL1"
                     /coded_by="XM_024449423.2:193..1665"
                     /db_xref="GeneID:84056"
                     /db_xref="HGNC:HGNC:28361"
                     /db_xref="MIM:614764"
ORIGIN      
        1 mnlaeicdna kkgreyallg nydssmvyyq gvmqqiqrhc qsvrdpaikg kwqqvrqell
       61 eeyeqvksiv stlesfkidk ppdfpvscqd epfrdpavwp ppvpaehrap pqirrpnrev
      121 rplrkemagv gargpvgrah pisksekpst srdkdyrarg rddkgrknmq dgasdgempk
      181 fdgagydkdl vealerdivs rnpsihwddi adleeakkll reavvlpmwm pdffkgirrp
      241 wkgvlmvgpp gtgktmlaka vatecgttff nvssstltsk yrgeseklvr llfemarfya
      301 pttifideid sicsrrgtsd eheasrrvks elliqmdgvg galenddpsk mvmvlaatnf
      361 pwdidealrr rlekriyipl ptakgraell kinlreveld pdiqlediae kiegysgadi
      421 tnvcrdaslm amrrringls peeiralske elqmpvtkgd felalkkiak svsaadleky
      481 ekwmvefgsa
//
LOCUS       XP_005266631             490 aa            linear   PRI 05-AUG-2025
DEFINITION  katanin p60 ATPase-containing subunit A-like 1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_005266631
VERSION     XP_005266631.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266574.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..490
                     /product="katanin p60 ATPase-containing subunit A-like 1
                     isoform X1"
                     /calculated_mol_wt=55261
     Region          4..72
                     /region_name="Kp60-NTD"
                     /note="N-terminal domain (NTD) found in katanin p60 (Kp60)
                     ATPase-containing subunit A1, and similar proteins;
                     cd21748"
                     /db_xref="CDD:439297"
     Site            order(7,14,17..20,22,29,51,55,58..59,61..62,65..66,68..69,
                     72)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:439297"
     Region          209..378
                     /region_name="RecA-like_KTNA1"
                     /note="Katanin p60 ATPase-containing subunit A1; cd19522"
                     /db_xref="CDD:410930"
     Site            order(210..213,250..256)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:410930"
     Region          402..446
                     /region_name="AAA_lid_3"
                     /note="AAA+ lid domain; pfam17862"
                     /db_xref="CDD:465537"
     Region          <450..488
                     /region_name="Vps4_C"
                     /note="Vps4 C terminal oligomerization domain; pfam09336"
                     /db_xref="CDD:462762"
     CDS             1..490
                     /gene="KATNAL1"
                     /coded_by="XM_005266574.4:159..1631"
                     /db_xref="GeneID:84056"
                     /db_xref="HGNC:HGNC:28361"
                     /db_xref="MIM:614764"
ORIGIN      
        1 mnlaeicdna kkgreyallg nydssmvyyq gvmqqiqrhc qsvrdpaikg kwqqvrqell
       61 eeyeqvksiv stlesfkidk ppdfpvscqd epfrdpavwp ppvpaehrap pqirrpnrev
      121 rplrkemagv gargpvgrah pisksekpst srdkdyrarg rddkgrknmq dgasdgempk
      181 fdgagydkdl vealerdivs rnpsihwddi adleeakkll reavvlpmwm pdffkgirrp
      241 wkgvlmvgpp gtgktmlaka vatecgttff nvssstltsk yrgeseklvr llfemarfya
      301 pttifideid sicsrrgtsd eheasrrvks elliqmdgvg galenddpsk mvmvlaatnf
      361 pwdidealrr rlekriyipl ptakgraell kinlreveld pdiqlediae kiegysgadi
      421 tnvcrdaslm amrrringls peeiralske elqmpvtkgd felalkkiak svsaadleky
      481 ekwmvefgsa
//
LOCUS       XP_024305192             490 aa            linear   PRI 05-AUG-2025
DEFINITION  katanin p60 ATPase-containing subunit A-like 1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_024305192
VERSION     XP_024305192.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449424.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..490
                     /product="katanin p60 ATPase-containing subunit A-like 1
                     isoform X1"
                     /calculated_mol_wt=55261
     Region          4..72
                     /region_name="Kp60-NTD"
                     /note="N-terminal domain (NTD) found in katanin p60 (Kp60)
                     ATPase-containing subunit A1, and similar proteins;
                     cd21748"
                     /db_xref="CDD:439297"
     Site            order(7,14,17..20,22,29,51,55,58..59,61..62,65..66,68..69,
                     72)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:439297"
     Region          209..378
                     /region_name="RecA-like_KTNA1"
                     /note="Katanin p60 ATPase-containing subunit A1; cd19522"
                     /db_xref="CDD:410930"
     Site            order(210..213,250..256)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:410930"
     Region          402..446
                     /region_name="AAA_lid_3"
                     /note="AAA+ lid domain; pfam17862"
                     /db_xref="CDD:465537"
     Region          <450..488
                     /region_name="Vps4_C"
                     /note="Vps4 C terminal oligomerization domain; pfam09336"
                     /db_xref="CDD:462762"
     CDS             1..490
                     /gene="KATNAL1"
                     /coded_by="XM_024449424.2:112..1584"
                     /db_xref="GeneID:84056"
                     /db_xref="HGNC:HGNC:28361"
                     /db_xref="MIM:614764"
ORIGIN      
        1 mnlaeicdna kkgreyallg nydssmvyyq gvmqqiqrhc qsvrdpaikg kwqqvrqell
       61 eeyeqvksiv stlesfkidk ppdfpvscqd epfrdpavwp ppvpaehrap pqirrpnrev
      121 rplrkemagv gargpvgrah pisksekpst srdkdyrarg rddkgrknmq dgasdgempk
      181 fdgagydkdl vealerdivs rnpsihwddi adleeakkll reavvlpmwm pdffkgirrp
      241 wkgvlmvgpp gtgktmlaka vatecgttff nvssstltsk yrgeseklvr llfemarfya
      301 pttifideid sicsrrgtsd eheasrrvks elliqmdgvg galenddpsk mvmvlaatnf
      361 pwdidealrr rlekriyipl ptakgraell kinlreveld pdiqlediae kiegysgadi
      421 tnvcrdaslm amrrringls peeiralske elqmpvtkgd felalkkiak svsaadleky
      481 ekwmvefgsa
//
LOCUS       XP_047286659             490 aa            linear   PRI 05-AUG-2025
DEFINITION  katanin p60 ATPase-containing subunit A-like 1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_047286659
VERSION     XP_047286659.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430703.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..490
                     /product="katanin p60 ATPase-containing subunit A-like 1
                     isoform X1"
                     /calculated_mol_wt=55261
     Region          4..72
                     /region_name="Kp60-NTD"
                     /note="N-terminal domain (NTD) found in katanin p60 (Kp60)
                     ATPase-containing subunit A1, and similar proteins;
                     cd21748"
                     /db_xref="CDD:439297"
     Site            order(7,14,17..20,22,29,51,55,58..59,61..62,65..66,68..69,
                     72)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:439297"
     Region          209..378
                     /region_name="RecA-like_KTNA1"
                     /note="Katanin p60 ATPase-containing subunit A1; cd19522"
                     /db_xref="CDD:410930"
     Site            order(210..213,250..256)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:410930"
     Region          402..446
                     /region_name="AAA_lid_3"
                     /note="AAA+ lid domain; pfam17862"
                     /db_xref="CDD:465537"
     Region          <450..488
                     /region_name="Vps4_C"
                     /note="Vps4 C terminal oligomerization domain; pfam09336"
                     /db_xref="CDD:462762"
     CDS             1..490
                     /gene="KATNAL1"
                     /coded_by="XM_047430703.1:12318..13790"
                     /db_xref="GeneID:84056"
                     /db_xref="HGNC:HGNC:28361"
                     /db_xref="MIM:614764"
ORIGIN      
        1 mnlaeicdna kkgreyallg nydssmvyyq gvmqqiqrhc qsvrdpaikg kwqqvrqell
       61 eeyeqvksiv stlesfkidk ppdfpvscqd epfrdpavwp ppvpaehrap pqirrpnrev
      121 rplrkemagv gargpvgrah pisksekpst srdkdyrarg rddkgrknmq dgasdgempk
      181 fdgagydkdl vealerdivs rnpsihwddi adleeakkll reavvlpmwm pdffkgirrp
      241 wkgvlmvgpp gtgktmlaka vatecgttff nvssstltsk yrgeseklvr llfemarfya
      301 pttifideid sicsrrgtsd eheasrrvks elliqmdgvg galenddpsk mvmvlaatnf
      361 pwdidealrr rlekriyipl ptakgraell kinlreveld pdiqlediae kiegysgadi
      421 tnvcrdaslm amrrringls peeiralske elqmpvtkgd felalkkiak svsaadleky
      481 ekwmvefgsa
//
LOCUS       XP_016876282             322 aa            linear   PRI 05-AUG-2025
DEFINITION  katanin p60 ATPase-containing subunit A-like 1 isoform X2 [Homo
            sapiens].
ACCESSION   XP_016876282
VERSION     XP_016876282.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020793.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..322
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..322
                     /product="katanin p60 ATPase-containing subunit A-like 1
                     isoform X2"
                     /calculated_mol_wt=36013
     Region          41..210
                     /region_name="RecA-like_KTNA1"
                     /note="Katanin p60 ATPase-containing subunit A1; cd19522"
                     /db_xref="CDD:410930"
     Site            order(42..45,82..88)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:410930"
     Region          234..278
                     /region_name="AAA_lid_3"
                     /note="AAA+ lid domain; pfam17862"
                     /db_xref="CDD:465537"
     Region          <282..320
                     /region_name="Vps4_C"
                     /note="Vps4 C terminal oligomerization domain; pfam09336"
                     /db_xref="CDD:462762"
     CDS             1..322
                     /gene="KATNAL1"
                     /coded_by="XM_017020793.3:320..1288"
                     /db_xref="GeneID:84056"
                     /db_xref="HGNC:HGNC:28361"
                     /db_xref="MIM:614764"
ORIGIN      
        1 mqdgasdgem pkfdgagydk dlvealerdi vsrnpsihwd diadleeakk llreavvlpm
       61 wmpdffkgir rpwkgvlmvg ppgtgktmla kavatecgtt ffnvssstlt skyrgesekl
      121 vrllfemarf yapttifide idsicsrrgt sdeheasrrv kselliqmdg vggalenddp
      181 skmvmvlaat nfpwdideal rrrlekriyi plptakgrae llkinlreve ldpdiqledi
      241 aekiegysga ditnvcrdas lmamrrring lspeeirals keelqmpvtk gdfelalkki
      301 aksvsaadle kyekwmvefg sa
//
LOCUS       XP_047286660             322 aa            linear   PRI 05-AUG-2025
DEFINITION  katanin p60 ATPase-containing subunit A-like 1 isoform X2 [Homo
            sapiens].
ACCESSION   XP_047286660
VERSION     XP_047286660.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430704.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..322
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..322
                     /product="katanin p60 ATPase-containing subunit A-like 1
                     isoform X2"
                     /calculated_mol_wt=36013
     Region          41..210
                     /region_name="RecA-like_KTNA1"
                     /note="Katanin p60 ATPase-containing subunit A1; cd19522"
                     /db_xref="CDD:410930"
     Site            order(42..45,82..88)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:410930"
     Region          234..278
                     /region_name="AAA_lid_3"
                     /note="AAA+ lid domain; pfam17862"
                     /db_xref="CDD:465537"
     Region          <282..320
                     /region_name="Vps4_C"
                     /note="Vps4 C terminal oligomerization domain; pfam09336"
                     /db_xref="CDD:462762"
     CDS             1..322
                     /gene="KATNAL1"
                     /coded_by="XM_047430704.1:114..1082"
                     /db_xref="GeneID:84056"
                     /db_xref="HGNC:HGNC:28361"
                     /db_xref="MIM:614764"
ORIGIN      
        1 mqdgasdgem pkfdgagydk dlvealerdi vsrnpsihwd diadleeakk llreavvlpm
       61 wmpdffkgir rpwkgvlmvg ppgtgktmla kavatecgtt ffnvssstlt skyrgesekl
      121 vrllfemarf yapttifide idsicsrrgt sdeheasrrv kselliqmdg vggalenddp
      181 skmvmvlaat nfpwdideal rrrlekriyi plptakgrae llkinlreve ldpdiqledi
      241 aekiegysga ditnvcrdas lmamrrring lspeeirals keelqmpvtk gdfelalkki
      301 aksvsaadle kyekwmvefg sa
//
LOCUS       XP_011519424             818 aa            linear   PRI 05-AUG-2025
DEFINITION  protein O-mannosyl-transferase TMTC4 isoform X1 [Homo sapiens].
ACCESSION   XP_011519424
VERSION     XP_011519424.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521122.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..818
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..818
                     /product="protein O-mannosyl-transferase TMTC4 isoform X1"
                     /calculated_mol_wt=91272
     Region          369..443
                     /region_name="TMTC_DUF1736"
                     /note="Protein O-mannosyl-transferase TMTC, DUF1736;
                     pfam08409"
                     /db_xref="CDD:462468"
     Region          552..763
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          559..587
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(560,563..564,567..568,570,594,597..598,601..602,
                     604..605,628,631..632,635..636,639)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          592..622
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          627..655
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          661..687
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          695..723
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          713..>815
                     /region_name="NrfG"
                     /note="Cytochrome c-type biogenesis protein CcmH/NrfG
                     [Energy production and conversion, Posttranslational
                     modification, protein turnover, chaperones]; COG4235"
                     /db_xref="CDD:443378"
     Region          728..758
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          763..791
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..818
                     /gene="TMTC4"
                     /gene_synonym="DFNB122"
                     /coded_by="XM_011521122.4:344..2800"
                     /db_xref="GeneID:84899"
                     /db_xref="HGNC:HGNC:25904"
                     /db_xref="MIM:618203"
ORIGIN      
        1 mipnqhnaga gshqpavfrm avldtdldhi lpssvlppfw aklvvgsvai vcfarsydgd
       61 fvfddseaiv nnkdlqaetp lgdlwhhdfw gsrlssntsh ksyrpltvlt frinyylsgg
      121 fhpvgfhvvn illhsgisvl mvdvfsvlfg glqytskgrr lhlaprasll aallfavhpv
      181 htecvagvvg radllcalff llsflgycka fresnkegah sstfwvllsi flgavamlck
      241 eqgitvlsck lievavlhtt alpgkgllss mcgfqshpvh lhssqleget kwecvpkfyn
      301 qtskmglnav fdilvigkfn vleivqkvlh kdkslenlgm lrnggllfrm tlltsggagm
      361 lyvrwrimgt gppaftevdn pasfadsmlv ravnynyyys lnawlllcpw wlcfdwsmgc
      421 ipliksisdw rvialaalwf cliglicqal csedghkrri ltlglgflvi pflpasnlff
      481 rvgfvvaerv lylpsvgycv lltfgfgals khtkkkklia avvlgilfin tlrcvlrsge
      541 wrseeqlfrs alsvcplnak vhynigknla dkgnqtaair yyreavrlnp kyvhamnnlg
      601 nilkernelq eaeellslav qiqpdfaaaw mnlgivqnsl krfeaaeqsy rtaikhrrky
      661 pdcyynlgrl yadlnrhvda lnawrnatvl kpehslawnn miilldntgn laqaeavgre
      721 alelipndhs lmfslanvlg ksqkykesea lflkaikanp naasyhgnla vlyhrwghld
      781 lakkhyeisl qldptasgtk enygllrrkl elmqkkav
//
LOCUS       XP_047286661             799 aa            linear   PRI 05-AUG-2025
DEFINITION  protein O-mannosyl-transferase TMTC4 isoform X2 [Homo sapiens].
ACCESSION   XP_047286661
VERSION     XP_047286661.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430705.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..799
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..799
                     /product="protein O-mannosyl-transferase TMTC4 isoform X2"
                     /calculated_mol_wt=89258
     Region          350..424
                     /region_name="TMTC_DUF1736"
                     /note="Protein O-mannosyl-transferase TMTC, DUF1736;
                     pfam08409"
                     /db_xref="CDD:462468"
     Region          533..744
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          540..568
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(541,544..545,548..549,551,575,578..579,582..583,
                     585..586,609,612..613,616..617,620)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          573..603
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          608..636
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          642..668
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          676..704
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          694..>796
                     /region_name="NrfG"
                     /note="Cytochrome c-type biogenesis protein CcmH/NrfG
                     [Energy production and conversion, Posttranslational
                     modification, protein turnover, chaperones]; COG4235"
                     /db_xref="CDD:443378"
     Region          709..739
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          744..772
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..799
                     /gene="TMTC4"
                     /gene_synonym="DFNB122"
                     /coded_by="XM_047430705.1:144..2543"
                     /db_xref="GeneID:84899"
                     /db_xref="HGNC:HGNC:25904"
                     /db_xref="MIM:618203"
ORIGIN      
        1 mavldtdldh ilpssvlppf waklvvgsva ivcfarsydg dfvfddseai vnnkdlqaet
       61 plgdlwhhdf wgsrlssnts hksyrpltvl tfrinyylsg gfhpvgfhvv nillhsgisv
      121 lmvdvfsvlf gglqytskgr rlhlaprasl laallfavhp vhtecvagvv gradllcalf
      181 fllsflgyck afresnkega hsstfwvlls iflgavamlc keqgitvlsc klievavlht
      241 talpgkglls smcgfqshpv hlhssqlege tkwecvpkfy nqtskmglna vfdilvigkf
      301 nvleivqkvl hkdkslenlg mlrnggllfr mtlltsggag mlyvrwrimg tgppaftevd
      361 npasfadsml vravnynyyy slnawlllcp wwlcfdwsmg cipliksisd wrvialaalw
      421 fcliglicqa lcsedghkrr iltlglgflv ipflpasnlf frvgfvvaer vlylpsvgyc
      481 vlltfgfgal skhtkkkkli aavvlgilfi ntlrcvlrsg ewrseeqlfr salsvcplna
      541 kvhynigknl adkgnqtaai ryyreavrln pkyvhamnnl gnilkernel qeaeellsla
      601 vqiqpdfaaa wmnlgivqns lkrfeaaeqs yrtaikhrrk ypdcyynlgr lyadlnrhvd
      661 alnawrnatv lkpehslawn nmiilldntg nlaqaeavgr ealelipndh slmfslanvl
      721 gksqkykese alflkaikan pnaasyhgnl avlyhrwghl dlakkhyeis lqldptasgt
      781 kenygllrrk lelmqkkav
//
LOCUS       XP_047286662             760 aa            linear   PRI 05-AUG-2025
DEFINITION  protein O-mannosyl-transferase TMTC4 isoform X3 [Homo sapiens].
ACCESSION   XP_047286662
VERSION     XP_047286662.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430706.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..760
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..760
                     /product="protein O-mannosyl-transferase TMTC4 isoform X3"
                     /calculated_mol_wt=84874
     Region          311..385
                     /region_name="TMTC_DUF1736"
                     /note="Protein O-mannosyl-transferase TMTC, DUF1736;
                     pfam08409"
                     /db_xref="CDD:462468"
     Region          494..705
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          501..529
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(502,505..506,509..510,512,536,539..540,543..544,
                     546..547,570,573..574,577..578,581)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          534..564
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          569..597
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          603..629
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          637..665
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          655..>757
                     /region_name="NrfG"
                     /note="Cytochrome c-type biogenesis protein CcmH/NrfG
                     [Energy production and conversion, Posttranslational
                     modification, protein turnover, chaperones]; COG4235"
                     /db_xref="CDD:443378"
     Region          670..700
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          705..733
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..760
                     /gene="TMTC4"
                     /gene_synonym="DFNB122"
                     /coded_by="XM_047430706.1:344..2626"
                     /db_xref="GeneID:84899"
                     /db_xref="HGNC:HGNC:25904"
                     /db_xref="MIM:618203"
ORIGIN      
        1 mipnqhnaga gshqpavfrm avldtdldhi lpssvlppfw aklvvgsvai vcfarsydgd
       61 fvfddseaiv nnkdlqaetp lgdlwhhdfw gsrlssntsh ksyrpltvlt frinyylsgg
      121 fhpvgfhvvn illhsgisvl mvdvfsvlfg glqytskgrr lhlaprasll aallfavhpv
      181 htecvagvvg radllcalff llsflgycka fresnkegah sstfwvllsi flgavamlck
      241 eqgitvlgln avfdilvigk fnvleivqkv lhkdkslenl gmlrnggllf rmtlltsgga
      301 gmlyvrwrim gtgppaftev dnpasfadsm lvravnynyy yslnawlllc pwwlcfdwsm
      361 gcipliksis dwrvialaal wfcliglicq alcsedghkr riltlglgfl vipflpasnl
      421 ffrvgfvvae rvlylpsvgy cvlltfgfga lskhtkkkkl iaavvlgilf intlrcvlrs
      481 gewrseeqlf rsalsvcpln akvhynigkn ladkgnqtaa iryyreavrl npkyvhamnn
      541 lgnilkerne lqeaeellsl avqiqpdfaa awmnlgivqn slkrfeaaeq syrtaikhrr
      601 kypdcyynlg rlyadlnrhv dalnawrnat vlkpehslaw nnmiilldnt gnlaqaeavg
      661 realelipnd hslmfslanv lgksqkykes ealflkaika npnaasyhgn lavlyhrwgh
      721 ldlakkhyei slqldptasg tkenygllrr klelmqkkav
//
LOCUS       XP_016876290             152 aa            linear   PRI 05-AUG-2025
DEFINITION  mesenteric estrogen-dependent adipogenesis protein isoform X1 [Homo
            sapiens].
ACCESSION   XP_016876290
VERSION     XP_016876290.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020801.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..152
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..152
                     /product="mesenteric estrogen-dependent adipogenesis
                     protein isoform X1"
                     /calculated_mol_wt=17115
     CDS             1..152
                     /gene="MEDAG"
                     /gene_synonym="AWMS3; C13orf33; hAWMS3; MEDA-4; MEDA4"
                     /coded_by="XM_017020801.2:1178..1636"
                     /db_xref="GeneID:84935"
                     /db_xref="HGNC:HGNC:25926"
ORIGIN      
        1 mdmvissvig esyrlqfdfq eavknffppg nevvngenls fayefkadal fdffywfgls
       61 nsvvkvngkv lnlsstspek ketiklflek mseplirrss fsdrkfsvts rgsiddvfnc
      121 nlsprsslte pllaelpfps vleseetpnq fi
//
LOCUS       XP_011519430             337 aa            linear   PRI 05-AUG-2025
DEFINITION  protein ABHD13 isoform X1 [Homo sapiens].
ACCESSION   XP_011519430
VERSION     XP_011519430.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521128.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..337
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..337
                     /product="protein ABHD13 isoform X1"
                     /calculated_mol_wt=38417
     Region          76..317
                     /region_name="FrsA"
                     /note="Fermentation-respiration switch esterase FrsA,
                     DUF1100 family [Signal transduction mechanisms]; COG1073"
                     /db_xref="CDD:440691"
     CDS             1..337
                     /gene="ABHD13"
                     /gene_synonym="bA153I24.2; BEM46L1; C13orf6"
                     /coded_by="XM_011521128.4:229..1242"
                     /db_xref="GeneID:84945"
                     /db_xref="HGNC:HGNC:20293"
                     /db_xref="MIM:621039"
ORIGIN      
        1 mekswmlwnf verwlialas wswalcrisl lplivtfhly ggiillllif isiagilykf
       61 qdvllyfpeq psssrlyvpm ptgiphenif irtkdgirln lilirytgdn spysptiiyf
      121 hgnagnighr lpnallmlvn lkvnlllvdy rgygksegea seeglyldse avldyvmtrp
      181 dldktkiflf grslggavai hlasenshri saimventfl siphmastlf sffpmrylpl
      241 wcyknkflsy rkisqcrmps lfisglsdql ippvmmkqly elspsrtkrl aifpdgthnd
      301 twqcqgyfta leqfikevvk shspeemakt ssnvtii
//
LOCUS       XP_016876291             263 aa            linear   PRI 05-AUG-2025
DEFINITION  tumor necrosis factor ligand superfamily member 11 isoform X1 [Homo
            sapiens].
ACCESSION   XP_016876291
VERSION     XP_016876291.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020802.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..263
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..263
                     /product="tumor necrosis factor ligand superfamily member
                     11 isoform X1"
                     /calculated_mol_wt=29751
     Site            order(113,161,163,222,227,253,257)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:238108"
     Region          131..259
                     /region_name="TNF"
                     /note="TNF(Tumour Necrosis Factor) family; pfam00229"
                     /db_xref="CDD:425540"
     Site            order(134..135,140,185,192,197)
                     /site_type="active"
                     /note="receptor binding sites [active]"
                     /db_xref="CDD:238108"
     CDS             1..263
                     /gene="TNFSF11"
                     /gene_synonym="CD254; hRANKL2; ODF; OPGL; OPTB2; RANKL;
                     sOdf; TNLG6B; TRANCE"
                     /coded_by="XM_017020802.2:819..1610"
                     /db_xref="GeneID:8600"
                     /db_xref="HGNC:HGNC:11926"
                     /db_xref="MIM:602642"
ORIGIN      
        1 mrgstkktdd tsdfkfclem dpnrisedgt hciyrilrlh enadfqdttl esqdtklipd
       61 scrrikqafq gavqkelqhi vgsqhiraek amvdgswldl akrskleaqp fahltinatd
      121 ipsgshkvsl sswyhdrgwa kisnmtfsng klivnqdgfy ylyanicfrh hetsgdlate
      181 ylqlmvyvtk tsikipssht lmkggstkyw sgnsefhfys invggffklr sgeeisievs
      241 npslldpdqd atyfgafkvr did
//
LOCUS       XP_047286663             244 aa            linear   PRI 05-AUG-2025
DEFINITION  tumor necrosis factor ligand superfamily member 11 isoform X2 [Homo
            sapiens].
ACCESSION   XP_047286663
VERSION     XP_047286663.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430707.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..244
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..244
                     /product="tumor necrosis factor ligand superfamily member
                     11 isoform X2"
                     /calculated_mol_wt=27559
     Site            order(94,142,144,203,208,234,238)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:238108"
     Region          112..240
                     /region_name="TNF"
                     /note="TNF(Tumour Necrosis Factor) family; pfam00229"
                     /db_xref="CDD:425540"
     Site            order(115..116,121,166,173,178)
                     /site_type="active"
                     /note="receptor binding sites [active]"
                     /db_xref="CDD:238108"
     CDS             1..244
                     /gene="TNFSF11"
                     /gene_synonym="CD254; hRANKL2; ODF; OPGL; OPTB2; RANKL;
                     sOdf; TNLG6B; TRANCE"
                     /coded_by="XM_047430707.1:1186..1920"
                     /db_xref="GeneID:8600"
                     /db_xref="HGNC:HGNC:11926"
                     /db_xref="MIM:602642"
ORIGIN      
        1 mdpnrisedg thciyrilrl henadfqdtt lesqdtklip dscrrikqaf qgavqkelqh
       61 ivgsqhirae kamvdgswld lakrskleaq pfahltinat dipsgshkvs lsswyhdrgw
      121 akisnmtfsn gklivnqdgf yylyanicfr hhetsgdlat eylqlmvyvt ktsikipssh
      181 tlmkggstky wsgnsefhfy sinvggffkl rsgeeisiev snpslldpdq datyfgafkv
      241 rdid
//
LOCUS       XP_047286664             153 aa            linear   PRI 05-AUG-2025
DEFINITION  gamma-glutamylaminecyclotransferase isoform X1 [Homo sapiens].
ACCESSION   XP_047286664
VERSION     XP_047286664.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430708.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..153
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..153
                     /product="gamma-glutamylaminecyclotransferase isoform X1"
                     /calculated_mol_wt=17197
     Region          4..138
                     /region_name="GGACT"
                     /note="Gamma-glutamyl cyclotransferase, AIG2-like;
                     pfam06094"
                     /db_xref="CDD:428763"
     Site            order(4,7,9..10,81..82,88)
                     /site_type="active"
                     /note="putative active site pocket [active]"
                     /db_xref="CDD:119400"
     Site            order(54,57,59,88..92,94,117)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:119400"
     Site            82
                     /site_type="active"
                     /note="putative catalytic residue [active]"
                     /db_xref="CDD:119400"
     CDS             1..153
                     /gene="GGACT"
                     /gene_synonym="A2LD1"
                     /coded_by="XM_047430708.1:374..835"
                     /db_xref="GeneID:87769"
                     /db_xref="HGNC:HGNC:25100"
                     /db_xref="MIM:613378"
ORIGIN      
        1 malvfvygtl krgqpnhrvl rdgahgsaaf rargrtlepy plviagehni pwllhlpgsg
       61 rlvegevyav dermlrfldd fescpalyqr tvlrvqlled rapgaeeppa ptavqcfvys
      121 ratfppewaq lphhdsydse gphglrynpr enr
//
LOCUS       XP_011519431             153 aa            linear   PRI 05-AUG-2025
DEFINITION  gamma-glutamylaminecyclotransferase isoform X1 [Homo sapiens].
ACCESSION   XP_011519431
VERSION     XP_011519431.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521129.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..153
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..153
                     /product="gamma-glutamylaminecyclotransferase isoform X1"
                     /calculated_mol_wt=17197
     Region          4..138
                     /region_name="GGACT"
                     /note="Gamma-glutamyl cyclotransferase, AIG2-like;
                     pfam06094"
                     /db_xref="CDD:428763"
     Site            order(4,7,9..10,81..82,88)
                     /site_type="active"
                     /note="putative active site pocket [active]"
                     /db_xref="CDD:119400"
     Site            order(54,57,59,88..92,94,117)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:119400"
     Site            82
                     /site_type="active"
                     /note="putative catalytic residue [active]"
                     /db_xref="CDD:119400"
     CDS             1..153
                     /gene="GGACT"
                     /gene_synonym="A2LD1"
                     /coded_by="XM_011521129.4:5582..6043"
                     /db_xref="GeneID:87769"
                     /db_xref="HGNC:HGNC:25100"
                     /db_xref="MIM:613378"
ORIGIN      
        1 malvfvygtl krgqpnhrvl rdgahgsaaf rargrtlepy plviagehni pwllhlpgsg
       61 rlvegevyav dermlrfldd fescpalyqr tvlrvqlled rapgaeeppa ptavqcfvys
      121 ratfppewaq lphhdsydse gphglrynpr enr
//
LOCUS       XP_011533585             687 aa            linear   PRI 05-AUG-2025
DEFINITION  sciellin isoform X1 [Homo sapiens].
ACCESSION   XP_011533585
VERSION     XP_011533585.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535283.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..687
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..687
                     /product="sciellin isoform X1"
                     /calculated_mol_wt=77334
     Region          619..677
                     /region_name="LIM"
                     /note="Zinc-binding domain present in Lin-11, Isl-1,
                     Mec-3; smart00132"
                     /db_xref="CDD:214528"
     Site            order(620,623,643,646,649,652,674,677)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..687
                     /gene="SCEL"
                     /coded_by="XM_011535283.2:139..2202"
                     /db_xref="GeneID:8796"
                     /db_xref="HGNC:HGNC:10573"
                     /db_xref="MIM:604112"
ORIGIN      
        1 msnvtlrkms ptgnemkstt qgttrkqqdf hevnkrrtfl qdnswikkrp eeekdenygr
       61 vvlnrhnshd aldrkvnerd vpkatisrys sddtldrisd rndaaktyka ntldnqltnr
      121 smsmfrslev tklqpggsln antsntiast sattpvkkkr qswfpppppg ynassstgtr
      181 rrepgvhppi ppkpsspvss pnqlrqdnrq ihppkpgvyt etnrsaerni rsqdldnivk
      241 vatslqrsdk geeldnlikm nkslnrnqgl dslfranpkv eerekraksl esliymstrt
      301 dkdgkgiqsl gspikvnqrt dknekgrqnl esvakvnarm nktsrrsedl dnatevnpkg
      361 henttgkkdl dglikvdpet nknitrgqsl dnlikvtpev krsnqgskdl nnfikvypgt
      421 eksteggqsl dslikvtper nrtnqgnqdl enlikvipsa nkseqgldeh invspkavkn
      481 tdgkqdldkl ikvnpeiftn nqrnqdlanl ikvnpavirn nqsqdldnli kvkpsalrnt
      541 nrdqnlenli evnshvsenk ngssntgakq agpqdtvvyt rtyvensksp kdgyqenisg
      601 kyiqtvysts drsvierdmc tycrkplgve tkmildelqi cchstcfkce ickqplenlq
      661 agdsiwiyrq tihcepcysk imakwip
//
LOCUS       XP_011533584             687 aa            linear   PRI 05-AUG-2025
DEFINITION  sciellin isoform X2 [Homo sapiens].
ACCESSION   XP_011533584
VERSION     XP_011533584.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535282.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..687
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..687
                     /product="sciellin isoform X2"
                     /calculated_mol_wt=77265
     Region          619..677
                     /region_name="LIM"
                     /note="Zinc-binding domain present in Lin-11, Isl-1,
                     Mec-3; smart00132"
                     /db_xref="CDD:214528"
     Site            order(620,623,643,646,649,652,674,677)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..687
                     /gene="SCEL"
                     /coded_by="XM_011535282.2:139..2202"
                     /db_xref="GeneID:8796"
                     /db_xref="HGNC:HGNC:10573"
                     /db_xref="MIM:604112"
ORIGIN      
        1 msnvtlrkms ptgnemkstt qgttrkqqdf hevnkrrtfl qdnswikkrp eeekdenygr
       61 vvlnrhnshd aldrkvnerd vpkatisrys sddtldrisd rndaaktyka ntldnqltnr
      121 smsmfrslev tklqpggsln antsntiast sattpvkkkr qswfpppppg ynassstgtr
      181 rrepgvhppi ppkpsspvss pnqlrqdnrq ihppkpgvyt etnrsaerni rsqdldnivk
      241 vatslqrsdk geeldnlikm nkslnrnqgl dslfranpkv eerekraksl esliymstrt
      301 dkdgkgiqsl gspikvnqrt dknekgqnle svakvnarmn ktsrrsedld natevnpkgh
      361 enttgkkdld glikvdpetn knitrgqsld nlikvtpevk rsnqgskdln nfikvypgte
      421 ksteggqsld slikvtpern rtnqgnqdle nlikvipsan ksseqgldeh invspkavkn
      481 tdgkqdldkl ikvnpeiftn nqrnqdlanl ikvnpavirn nqsqdldnli kvkpsalrnt
      541 nrdqnlenli evnshvsenk ngssntgakq agpqdtvvyt rtyvensksp kdgyqenisg
      601 kyiqtvysts drsvierdmc tycrkplgve tkmildelqi cchstcfkce ickqplenlq
      661 agdsiwiyrq tihcepcysk imakwip
//
LOCUS       XP_011533583             687 aa            linear   PRI 05-AUG-2025
DEFINITION  sciellin isoform X3 [Homo sapiens].
ACCESSION   XP_011533583
VERSION     XP_011533583.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535281.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..687
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..687
                     /product="sciellin isoform X3"
                     /calculated_mol_wt=77265
     Region          619..677
                     /region_name="LIM"
                     /note="Zinc-binding domain present in Lin-11, Isl-1,
                     Mec-3; smart00132"
                     /db_xref="CDD:214528"
     Site            order(620,623,643,646,649,652,674,677)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..687
                     /gene="SCEL"
                     /coded_by="XM_011535281.2:139..2202"
                     /db_xref="GeneID:8796"
                     /db_xref="HGNC:HGNC:10573"
                     /db_xref="MIM:604112"
ORIGIN      
        1 msnvtlrkms ptgnemkstt qgttrkqqdf hevnkrrtfl qdnswikkrp eeekdenygr
       61 vvlnrhnshd aldrkvnerd vpkatisrys sddtldrisd rndaaktyka ntldnqltnr
      121 smsmfrslev tklqpggsln antsntiast sattpvkkkr qswfpppppg ynassstgtr
      181 rrepgvhppi ppkpsspvss pnqlrqdnrq ihppkpgvyt etnrsaerni rsqdldnivk
      241 vatslqrsdk geeldnlikm nkslnrnqgl dslfranpkv eerekraksl esliymstrt
      301 dkdgkgiqsl gspikvnqrt dknekgrqnl esvakvnarm nktsrsedld natevnpkgh
      361 enttgkkdld glikvdpetn knitrgqsld nlikvtpevk rsnqgskdln nfikvypgte
      421 ksteggqsld slikvtpern rtnqgnqdle nlikvipsan ksseqgldeh invspkavkn
      481 tdgkqdldkl ikvnpeiftn nqrnqdlanl ikvnpavirn nqsqdldnli kvkpsalrnt
      541 nrdqnlenli evnshvsenk ngssntgakq agpqdtvvyt rtyvensksp kdgyqenisg
      601 kyiqtvysts drsvierdmc tycrkplgve tkmildelqi cchstcfkce ickqplenlq
      661 agdsiwiyrq tihcepcysk imakwip
//
LOCUS       XP_011533586             686 aa            linear   PRI 05-AUG-2025
DEFINITION  sciellin isoform X4 [Homo sapiens].
ACCESSION   XP_011533586
VERSION     XP_011533586.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535284.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..686
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..686
                     /product="sciellin isoform X4"
                     /calculated_mol_wt=77109
     Region          618..676
                     /region_name="LIM"
                     /note="Zinc-binding domain present in Lin-11, Isl-1,
                     Mec-3; smart00132"
                     /db_xref="CDD:214528"
     Site            order(619,622,642,645,648,651,673,676)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..686
                     /gene="SCEL"
                     /coded_by="XM_011535284.2:139..2199"
                     /db_xref="GeneID:8796"
                     /db_xref="HGNC:HGNC:10573"
                     /db_xref="MIM:604112"
ORIGIN      
        1 msnvtlrkms ptgnemkstt qgttrkqqdf hevnkrrtfl qdnswikkrp eeekdenygr
       61 vvlnrhnshd aldrkvnerd vpkatisrys sddtldrisd rndaaktyka ntldnqltnr
      121 smsmfrslev tklqpggsln antsntiast sattpvkkkr qswfpppppg ynassstgtr
      181 rrepgvhppi ppkpsspvss pnqlrqdnrq ihppkpgvyt etnrsaerni rsqdldnivk
      241 vatslqrsdk geeldnlikm nkslnrnqgl dslfranpkv eerekraksl esliymstrt
      301 dkdgkgiqsl gspikvnqrt dknekgqnle svakvnarmn ktsrsedldn atevnpkghe
      361 nttgkkdldg likvdpetnk nitrgqsldn likvtpevkr snqgskdlnn fikvypgtek
      421 steggqslds likvtpernr tnqgnqdlen likvipsank sseqgldehi nvspkavknt
      481 dgkqdldkli kvnpeiftnn qrnqdlanli kvnpavirnn qsqdldnlik vkpsalrntn
      541 rdqnlenlie vnshvsenkn gssntgakqa gpqdtvvytr tyvenskspk dgyqenisgk
      601 yiqtvystsd rsvierdmct ycrkplgvet kmildelqic chstcfkcei ckqplenlqa
      661 gdsiwiyrqt ihcepcyski makwip
//
LOCUS       XP_011533587             675 aa            linear   PRI 05-AUG-2025
DEFINITION  sciellin isoform X5 [Homo sapiens].
ACCESSION   XP_011533587
VERSION     XP_011533587.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535285.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..675
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..675
                     /product="sciellin isoform X5"
                     /calculated_mol_wt=75910
     Region          607..665
                     /region_name="LIM"
                     /note="Zinc-binding domain present in Lin-11, Isl-1,
                     Mec-3; smart00132"
                     /db_xref="CDD:214528"
     Site            order(608,611,631,634,637,640,662,665)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..675
                     /gene="SCEL"
                     /coded_by="XM_011535285.3:139..2166"
                     /db_xref="GeneID:8796"
                     /db_xref="HGNC:HGNC:10573"
                     /db_xref="MIM:604112"
ORIGIN      
        1 msnvtlrkms ptgnemkstt qgttrkqqdf hevnkrrtfl qdnswikkrp eeekdenygr
       61 vvlnrhnshd aldrkvnerd vpkatisrys sddtldrisd rndaaktyka ntldnqltnr
      121 qpggslnant sntiastsat tpvkkkrqsw fpppppgyna ssstgtrrre pgvhppippk
      181 psspvsspnq lrqdnrqihp pkpgvytetn rsaernirsq dldnivkvat slqrsdkgee
      241 ldnlikmnks lnrnqgldsl franpkveer ekrakslesl iymstrtdkd gkgiqslgsp
      301 ikvnqrtdkn ekgrqnlesv akvnarmnkt srrsedldna tevnpkghen ttgkkdldgl
      361 ikvdpetnkn itrgqsldnl ikvtpevkrs nqgskdlnnf ikvypgteks teggqsldsl
      421 ikvtpernrt nqgnqdlenl ikvipsanks seqgldehin vspkavkntd gkqdldklik
      481 vnpeiftnnq rnqdlanlik vnpavirnnq sqdldnlikv kpsalrntnr dqnlenliev
      541 nshvsenkng ssntgakqag pqdtvvytrt yvenskspkd gyqenisgky iqtvystsdr
      601 svierdmcty crkplgvetk mildelqicc hstcfkceic kqplenlqag dsiwiyrqti
      661 hcepcyskim akwip
//
LOCUS       XP_011533588             668 aa            linear   PRI 05-AUG-2025
DEFINITION  sciellin isoform X6 [Homo sapiens].
ACCESSION   XP_011533588
VERSION     XP_011533588.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535286.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..668
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..668
                     /product="sciellin isoform X6"
                     /calculated_mol_wt=75141
     Region          600..658
                     /region_name="LIM"
                     /note="Zinc-binding domain present in Lin-11, Isl-1,
                     Mec-3; smart00132"
                     /db_xref="CDD:214528"
     Site            order(601,604,624,627,630,633,655,658)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..668
                     /gene="SCEL"
                     /coded_by="XM_011535286.2:139..2145"
                     /db_xref="GeneID:8796"
                     /db_xref="HGNC:HGNC:10573"
                     /db_xref="MIM:604112"
ORIGIN      
        1 msnvtlrkms ptgnemkstt qgttrkqqdf hevnkrrtfl qdnswikkrp eeekdenygr
       61 vvlnrhnshd aldrkvnerd vpkatisrys sddtldrisd rndaaktyka ntldnqltnr
      121 smsmfrslev tklqpggsln antsntiast sattpvkkkr qswfpppppg ynassstgtr
      181 rrepgvhppi ppkpsspvss pnqlrqdnrq ihppkpgvyt etnrsaerni rsqdldnivk
      241 vatslqrsdk geeldnlikm nkslnrnqgl dslfranpkv eerekraksl esliymstrt
      301 dkdgkgiqsl gspikvnqrt dknekgrqnl esvakvnarm nktsrrsedl dnatevnpkg
      361 henttggqsl dnlikvtpev krsnqgskdl nnfikvypgt eksteggqsl dslikvtper
      421 nrtnqgnqdl enlikvipsa nksseqglde hinvspkavk ntdgkqdldk likvnpeift
      481 nnqrnqdlan likvnpavir nnqsqdldnl ikvkpsalrn tnrdqnlenl ievnshvsen
      541 kngssntgak qagpqdtvvy trtyvensks pkdgyqenis gkyiqtvyst sdrsvierdm
      601 ctycrkplgv etkmildelq icchstcfkc eickqplenl qagdsiwiyr qtihcepcys
      661 kimakwip
//
LOCUS       XP_006719945             668 aa            linear   PRI 05-AUG-2025
DEFINITION  sciellin isoform X7 [Homo sapiens].
ACCESSION   XP_006719945
VERSION     XP_006719945.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006719882.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..668
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..668
                     /product="sciellin isoform X7"
                     /calculated_mol_wt=75052
     Region          600..658
                     /region_name="LIM"
                     /note="Zinc-binding domain present in Lin-11, Isl-1,
                     Mec-3; smart00132"
                     /db_xref="CDD:214528"
     Site            order(601,604,624,627,630,633,655,658)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..668
                     /gene="SCEL"
                     /coded_by="XM_006719882.2:139..2145"
                     /db_xref="GeneID:8796"
                     /db_xref="HGNC:HGNC:10573"
                     /db_xref="MIM:604112"
ORIGIN      
        1 msnvtlrkms ptgnemkstt qgttrkqqdf hevnkrrtfl qdnswikkrp eeekdenygr
       61 vvlnrhnshd aldrkvnerd vpkatisrys sddtldrisd rndaaktyka ntldnqltnr
      121 smsmfrslev tklqpggsln antsntiast sattpvkkkr qswfpppppg ynassstgtr
      181 rrepgvhppi ppkpsspvss pnqlrqdnrq ihppkpgvyt etnrsaerni rsqdldnivk
      241 vatslqrsdk geeldnlikm nkslnraksl esliymstrt dkdgkgiqsl gspikvnqrt
      301 dknekgrqnl esvakvnarm nktsrrsedl dnatevnpkg henttgkkdl dglikvdpet
      361 nknitrgqsl dnlikvtpev krsnqgskdl nnfikvypgt eksteggqsl dslikvtper
      421 nrtnqgnqdl enlikvipsa nksseqglde hinvspkavk ntdgkqdldk likvnpeift
      481 nnqrnqdlan likvnpavir nnqsqdldnl ikvkpsalrn tnrdqnlenl ievnshvsen
      541 kngssntgak qagpqdtvvy trtyvensks pkdgyqenis gkyiqtvyst sdrsvierdm
      601 ctycrkplgv etkmildelq icchstcfkc eickqplenl qagdsiwiyr qtihcepcys
      661 kimakwip
//
LOCUS       XP_047286665             667 aa            linear   PRI 05-AUG-2025
DEFINITION  sciellin isoform X8 [Homo sapiens].
ACCESSION   XP_047286665
VERSION     XP_047286665.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430709.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..667
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..667
                     /product="sciellin isoform X8"
                     /calculated_mol_wt=75108
     Region          599..657
                     /region_name="LIM"
                     /note="Zinc-binding domain present in Lin-11, Isl-1,
                     Mec-3; smart00132"
                     /db_xref="CDD:214528"
     Site            order(600,603,623,626,629,632,654,657)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..667
                     /gene="SCEL"
                     /coded_by="XM_047430709.1:139..2142"
                     /db_xref="GeneID:8796"
                     /db_xref="HGNC:HGNC:10573"
                     /db_xref="MIM:604112"
ORIGIN      
        1 msnvtlrkms ptgnemkstt qgttrkqqdf hevnkrrtfl qdnswikkrp eeekdenygr
       61 vvlnrhnshd aldrkvnerd vpkatisrys sddtldrisd rndaaktyka ntldnqltnr
      121 smsmfrslev tklqpggsln antsntiast sattpvkkkr qswfpppppg ynassstgtr
      181 rrepgvhppi ppkpsspvss pnqlrqdnrq ihppkpgvyt etnrsaerni seeldnlikm
      241 nkslnrnqgl dslfranpkv eerekraksl esliymstrt dkdgkgiqsl gspikvnqrt
      301 dknekgrqnl esvakvnarm nktsrrsedl dnatevnpkg henttgkkdl dglikvdpet
      361 nknitrgqsl dnlikvtpev krsnqgskdl nnfikvypgt eksteggqsl dslikvtper
      421 nrtnqgnqdl enlikvipsa nkseqgldeh invspkavkn tdgkqdldkl ikvnpeiftn
      481 nqrnqdlanl ikvnpavirn nqsqdldnli kvkpsalrnt nrdqnlenli evnshvsenk
      541 ngssntgakq agpqdtvvyt rtyvensksp kdgyqenisg kyiqtvysts drsvierdmc
      601 tycrkplgve tkmildelqi cchstcfkce ickqplenlq agdsiwiyrq tihcepcysk
      661 imakwip
//
LOCUS       XP_047286666             667 aa            linear   PRI 05-AUG-2025
DEFINITION  sciellin isoform X9 [Homo sapiens].
ACCESSION   XP_047286666
VERSION     XP_047286666.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430710.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..667
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..667
                     /product="sciellin isoform X9"
                     /calculated_mol_wt=75054
     Region          599..657
                     /region_name="LIM"
                     /note="Zinc-binding domain present in Lin-11, Isl-1,
                     Mec-3; smart00132"
                     /db_xref="CDD:214528"
     Site            order(600,603,623,626,629,632,654,657)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..667
                     /gene="SCEL"
                     /coded_by="XM_047430710.1:139..2142"
                     /db_xref="GeneID:8796"
                     /db_xref="HGNC:HGNC:10573"
                     /db_xref="MIM:604112"
ORIGIN      
        1 msnvtlrkms ptgnemkstt qgttrkqqdf hevnkrrtfl qdnswikkrp eeekdenygr
       61 vvlnrhnshd aldrkvnerd vpkatisrys sddtldrisd rndaaktyka ntldnqltnr
      121 smsmfrslev tklqpggsln antsntiast sattpvkkkr qswfpppppg ynassstgtr
      181 rrepgvhppi ppkpsspvss pnqlrqdnrq ihppkpgvyt etnrsaerni rsqdldnivk
      241 vatslqrsdk geeldnlikm nkslnrnqgl dslfranpkv eerekraksl esliymstrt
      301 dkdgkgiqsl gspikvnqrt dknekgrqnl esvakvnarm nktsrrsedl dnatevnpkg
      361 henttggqsl dnlikvtpev krsnqgskdl nnfikvypgt eksteggqsl dslikvtper
      421 nrtnqgnqdl enlikvipsa nkseqgldeh invspkavkn tdgkqdldkl ikvnpeiftn
      481 nqrnqdlanl ikvnpavirn nqsqdldnli kvkpsalrnt nrdqnlenli evnshvsenk
      541 ngssntgakq agpqdtvvyt rtyvensksp kdgyqenisg kyiqtvysts drsvierdmc
      601 tycrkplgve tkmildelqi cchstcfkce ickqplenlq agdsiwiyrq tihcepcysk
      661 imakwip
//
LOCUS       XP_011533589             667 aa            linear   PRI 05-AUG-2025
DEFINITION  sciellin isoform X10 [Homo sapiens].
ACCESSION   XP_011533589
VERSION     XP_011533589.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535287.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..667
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..667
                     /product="sciellin isoform X10"
                     /calculated_mol_wt=74985
     Region          599..657
                     /region_name="LIM"
                     /note="Zinc-binding domain present in Lin-11, Isl-1,
                     Mec-3; smart00132"
                     /db_xref="CDD:214528"
     Site            order(600,603,623,626,629,632,654,657)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..667
                     /gene="SCEL"
                     /coded_by="XM_011535287.2:139..2142"
                     /db_xref="GeneID:8796"
                     /db_xref="HGNC:HGNC:10573"
                     /db_xref="MIM:604112"
ORIGIN      
        1 msnvtlrkms ptgnemkstt qgttrkqqdf hevnkrrtfl qdnswikkrp eeekdenygr
       61 vvlnrhnshd aldrkvnerd vpkatisrys sddtldrisd rndaaktyka ntldnqltnr
      121 smsmfrslev tklqpggsln antsntiast sattpvkkkr qswfpppppg ynassstgtr
      181 rrepgvhppi ppkpsspvss pnqlrqdnrq ihppkpgvyt etnrsaerni rsqdldnivk
      241 vatslqrsdk geeldnlikm nkslnrnqgl dslfranpkv eerekraksl esliymstrt
      301 dkdgkgiqsl gspikvnqrt dknekgrqnl esvakvnarm nktsrsedld natevnpkgh
      361 enttggqsld nlikvtpevk rsnqgskdln nfikvypgte ksteggqsld slikvtpern
      421 rtnqgnqdle nlikvipsan ksseqgldeh invspkavkn tdgkqdldkl ikvnpeiftn
      481 nqrnqdlanl ikvnpavirn nqsqdldnli kvkpsalrnt nrdqnlenli evnshvsenk
      541 ngssntgakq agpqdtvvyt rtyvensksp kdgyqenisg kyiqtvysts drsvierdmc
      601 tycrkplgve tkmildelqi cchstcfkce ickqplenlq agdsiwiyrq tihcepcysk
      661 imakwip
//
LOCUS       XP_006719947             666 aa            linear   PRI 05-AUG-2025
DEFINITION  sciellin isoform X11 [Homo sapiens].
ACCESSION   XP_006719947
VERSION     XP_006719947.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006719884.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..666
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..666
                     /product="sciellin isoform X11"
                     /calculated_mol_wt=74992
     Region          598..656
                     /region_name="LIM"
                     /note="Zinc-binding domain present in Lin-11, Isl-1,
                     Mec-3; smart00132"
                     /db_xref="CDD:214528"
     Site            order(599,602,622,625,628,631,653,656)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..666
                     /gene="SCEL"
                     /coded_by="XM_006719884.2:139..2139"
                     /db_xref="GeneID:8796"
                     /db_xref="HGNC:HGNC:10573"
                     /db_xref="MIM:604112"
ORIGIN      
        1 msnvtlrkms ptgnemkstt qgttrkqqdf hevnkrrtfl qdnswikkrp eeekdenygr
       61 vvlnrhnshd aldrkvnerd vpkatisrys sddtldrisd rndaaktyka ntldnqltnr
      121 smsmfrslev tklqpggsln antsntiast sattpvkkkr epgvhppipp kpsspvsspn
      181 qlrqdnrqih ppkpgvytet nrsaernirs qdldnivkva tslqrsdkge eldnlikmnk
      241 slnrnqglds lfranpkvee rekraksles liymstrtdk dgkgiqslgs pikvnqrtdk
      301 nekgrqnles vakvnarmnk tsrrsedldn atevnpkghe nttgkkdldg likvdpetnk
      361 nitrgqsldn likvtpevkr snqgskdlnn fikvypgtek steggqslds likvtpernr
      421 tnqgnqdlen likvipsank sseqgldehi nvspkavknt dgkqdldkli kvnpeiftnn
      481 qrnqdlanli kvnpavirnn qsqdldnlik vkpsalrntn rdqnlenlie vnshvsenkn
      541 gssntgakqa gpqdtvvytr tyvenskspk dgyqenisgk yiqtvystsd rsvierdmct
      601 ycrkplgvet kmildelqic chstcfkcei ckqplenlqa gdsiwiyrqt ihcepcyski
      661 makwip
//
LOCUS       XP_047286667             665 aa            linear   PRI 05-AUG-2025
DEFINITION  sciellin isoform X12 [Homo sapiens].
ACCESSION   XP_047286667
VERSION     XP_047286667.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430711.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..665
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..665
                     /product="sciellin isoform X12"
                     /calculated_mol_wt=74836
     Region          597..655
                     /region_name="LIM"
                     /note="Zinc-binding domain present in Lin-11, Isl-1,
                     Mec-3; smart00132"
                     /db_xref="CDD:214528"
     Site            order(598,601,621,624,627,630,652,655)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..665
                     /gene="SCEL"
                     /coded_by="XM_047430711.1:139..2136"
                     /db_xref="GeneID:8796"
                     /db_xref="HGNC:HGNC:10573"
                     /db_xref="MIM:604112"
ORIGIN      
        1 msnvtlrkms ptgnemkstt qgttrkqqdf hevnkrrtfl qdnswikkrp eeekdenygr
       61 vvlnrhnshd aldrkvnerd vpkatisrys sddtldrisd rndaaktyka ntldnqltnr
      121 smsmfrslev tklqpggsln antsntiast sattpvkkkr epgvhppipp kpsspvsspn
      181 qlrqdnrqih ppkpgvytet nrsaernirs qdldnivkva tslqrsdkge eldnlikmnk
      241 slnrnqglds lfranpkvee rekraksles liymstrtdk dgkgiqslgs pikvnqrtdk
      301 nekgqnlesv akvnarmnkt srrsedldna tevnpkghen ttgkkdldgl ikvdpetnkn
      361 itrgqsldnl ikvtpevkrs nqgskdlnnf ikvypgteks teggqsldsl ikvtpernrt
      421 nqgnqdlenl ikvipsanks seqgldehin vspkavkntd gkqdldklik vnpeiftnnq
      481 rnqdlanlik vnpavirnnq sqdldnlikv kpsalrntnr dqnlenliev nshvsenkng
      541 ssntgakqag pqdtvvytrt yvenskspkd gyqenisgky iqtvystsdr svierdmcty
      601 crkplgvetk mildelqicc hstcfkceic kqplenlqag dsiwiyrqti hcepcyskim
      661 akwip
//
LOCUS       XP_005266635             665 aa            linear   PRI 05-AUG-2025
DEFINITION  sciellin isoform X13 [Homo sapiens].
ACCESSION   XP_005266635
VERSION     XP_005266635.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266578.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..665
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..665
                     /product="sciellin isoform X13"
                     /calculated_mol_wt=74816
     Region          597..655
                     /region_name="LIM"
                     /note="Zinc-binding domain present in Lin-11, Isl-1,
                     Mec-3; smart00132"
                     /db_xref="CDD:214528"
     Site            order(598,601,621,624,627,630,652,655)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..665
                     /gene="SCEL"
                     /coded_by="XM_005266578.2:139..2136"
                     /db_xref="GeneID:8796"
                     /db_xref="HGNC:HGNC:10573"
                     /db_xref="MIM:604112"
ORIGIN      
        1 msnvtlrkms ptgnemkstt qgttrkqqdf hevnkrrtfl qdnswikkrp eeekdenygr
       61 vvlnrhnshd aldrkvnerd vpkatisrys sddtldrsms mfrslevtkl qpggslnant
      121 sntiastsat tpvkkkrqsw fpppppgyna ssstgtrrre pgvhppippk psspvsspnq
      181 lrqdnrqihp pkpgvytetn rsaernirsq dldnivkvat slqrsdkgee ldnlikmnks
      241 lnrnqgldsl franpkveer ekrakslesl iymstrtdkd gkgiqslgsp ikvnqrtdkn
      301 ekgrqnlesv akvnarmnkt srrsedldna tevnpkghen ttgkkdldgl ikvdpetnkn
      361 itrgqsldnl ikvtpevkrs nqgskdlnnf ikvypgteks teggqsldsl ikvtpernrt
      421 nqgnqdlenl ikvipsanks seqgldehin vspkavkntd gkqdldklik vnpeiftnnq
      481 rnqdlanlik vnpavirnnq sqdldnlikv kpsalrntnr dqnlenliev nshvsenkng
      541 ssntgakqag pqdtvvytrt yvenskspkd gyqenisgky iqtvystsdr svierdmcty
      601 crkplgvetk mildelqicc hstcfkceic kqplenlqag dsiwiyrqti hcepcyskim
      661 akwip
//
LOCUS       XP_011533590             652 aa            linear   PRI 05-AUG-2025
DEFINITION  sciellin isoform X14 [Homo sapiens].
ACCESSION   XP_011533590
VERSION     XP_011533590.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535288.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..652
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..652
                     /product="sciellin isoform X14"
                     /calculated_mol_wt=73305
     Region          584..642
                     /region_name="LIM"
                     /note="Zinc-binding domain present in Lin-11, Isl-1,
                     Mec-3; smart00132"
                     /db_xref="CDD:214528"
     Site            order(585,588,608,611,614,617,639,642)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..652
                     /gene="SCEL"
                     /coded_by="XM_011535288.2:139..2097"
                     /db_xref="GeneID:8796"
                     /db_xref="HGNC:HGNC:10573"
                     /db_xref="MIM:604112"
ORIGIN      
        1 msnvtlrkms ptgnemkstt qgttrkqqdf hevnkrrtfl qdnswikkrp eeekdenygr
       61 vvlnrhnshd aldrkvnerd vpkatisrys sddtldrqpg gslnantsnt iastsattpv
      121 kkkrqswfpp pppgynasss tgtrrrepgv hppippkpss pvsspnqlrq dnrqihppkp
      181 gvytetnrsa ernirsqdld nivkvatslq rsdkgeeldn likmnkslnr nqgldslfra
      241 npkveerekr akslesliym strtdkdgkg iqslgspikv nqrtdknekg rqnlesvakv
      301 narmnktsrr sedldnatev npkghenttg kkdldglikv dpetnknitr gqsldnlikv
      361 tpevkrsnqg skdlnnfikv ypgteksteg gqsldslikv tpernrtnqg nqdlenlikv
      421 ipsanksseq gldehinvsp kavkntdgkq dldklikvnp eiftnnqrnq dlanlikvnp
      481 avirnnqsqd ldnlikvkps alrntnrdqn lenlievnsh vsenkngssn tgakqagpqd
      541 tvvytrtyve nskspkdgyq enisgkyiqt vystsdrsvi erdmctycrk plgvetkmil
      601 delqicchst cfkceickqp lenlqagdsi wiyrqtihce pcyskimakw ip
//
LOCUS       XP_006719948             648 aa            linear   PRI 05-AUG-2025
DEFINITION  sciellin isoform X15 [Homo sapiens].
ACCESSION   XP_006719948
VERSION     XP_006719948.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006719885.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..648
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..648
                     /product="sciellin isoform X15"
                     /calculated_mol_wt=72827
     Region          580..638
                     /region_name="LIM"
                     /note="Zinc-binding domain present in Lin-11, Isl-1,
                     Mec-3; smart00132"
                     /db_xref="CDD:214528"
     Site            order(581,584,604,607,610,613,635,638)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..648
                     /gene="SCEL"
                     /coded_by="XM_006719885.2:139..2085"
                     /db_xref="GeneID:8796"
                     /db_xref="HGNC:HGNC:10573"
                     /db_xref="MIM:604112"
ORIGIN      
        1 msnvtlrkms ptgnemkstt qgttrkqqdf hevnkrrtfl qdnswikkrp eeekdenygr
       61 vvlnrhnshd aldrkvnerd vpkatisrys sddtldrisd rndaaktyka ntldnqltnr
      121 smsmfrslev tklqpggsln antsntiast sattpvkkkr qswfpppppg ynassstgtr
      181 rrepgvhppi ppkpsspvss pnqlrqdnrq ihppkpgvyt etnrsaerni seeldnlikm
      241 nkslnraksl esliymstrt dkdgkgiqsl gspikvnqrt dknekgrqnl esvakvnarm
      301 nktsrrsedl dnatevnpkg henttgkkdl dglikvdpet nknitrgqsl dnlikvtpev
      361 krsnqgskdl nnfikvypgt eksteggqsl dslikvtper nrtnqgnqdl enlikvipsa
      421 nksseqglde hinvspkavk ntdgkqdldk likvnpeift nnqrnqdlan likvnpavir
      481 nnqsqdldnl ikvkpsalrn tnrdqnlenl ievnshvsen kngssntgak qagpqdtvvy
      541 trtyvensks pkdgyqenis gkyiqtvyst sdrsvierdm ctycrkplgv etkmildelq
      601 icchstcfkc eickqplenl qagdsiwiyr qtihcepcys kimakwip
//
LOCUS       XP_047286668             648 aa            linear   PRI 05-AUG-2025
DEFINITION  sciellin isoform X16 [Homo sapiens].
ACCESSION   XP_047286668
VERSION     XP_047286668.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430712.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..648
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..648
                     /product="sciellin isoform X16"
                     /calculated_mol_wt=72916
     Region          580..638
                     /region_name="LIM"
                     /note="Zinc-binding domain present in Lin-11, Isl-1,
                     Mec-3; smart00132"
                     /db_xref="CDD:214528"
     Site            order(581,584,604,607,610,613,635,638)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..648
                     /gene="SCEL"
                     /coded_by="XM_047430712.1:139..2085"
                     /db_xref="GeneID:8796"
                     /db_xref="HGNC:HGNC:10573"
                     /db_xref="MIM:604112"
ORIGIN      
        1 msnvtlrkms ptgnemkstt qgttrkqqdf hevnkrrtfl qdnswikkrp eeekdenygr
       61 vvlnrhnshd aldrkvnerd vpkatisrys sddtldrisd rndaaktyka ntldnqltnr
      121 smsmfrslev tklqpggsln antsntiast sattpvkkkr qswfpppppg ynassstgtr
      181 rrepgvhppi ppkpsspvss pnqlrqdnrq ihppkpgvyt etnrsaerni seeldnlikm
      241 nkslnrnqgl dslfranpkv eerekraksl esliymstrt dkdgkgiqsl gspikvnqrt
      301 dknekgrqnl esvakvnarm nktsrrsedl dnatevnpkg henttggqsl dnlikvtpev
      361 krsnqgskdl nnfikvypgt eksteggqsl dslikvtper nrtnqgnqdl enlikvipsa
      421 nksseqglde hinvspkavk ntdgkqdldk likvnpeift nnqrnqdlan likvnpavir
      481 nnqsqdldnl ikvkpsalrn tnrdqnlenl ievnshvsen kngssntgak qagpqdtvvy
      541 trtyvensks pkdgyqenis gkyiqtvyst sdrsvierdm ctycrkplgv etkmildelq
      601 icchstcfkc eickqplenl qagdsiwiyr qtihcepcys kimakwip
//
LOCUS       XP_011533591             647 aa            linear   PRI 05-AUG-2025
DEFINITION  sciellin isoform X17 [Homo sapiens].
ACCESSION   XP_011533591
VERSION     XP_011533591.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535289.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..647
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..647
                     /product="sciellin isoform X17"
                     /calculated_mol_wt=72671
     Region          579..637
                     /region_name="LIM"
                     /note="Zinc-binding domain present in Lin-11, Isl-1,
                     Mec-3; smart00132"
                     /db_xref="CDD:214528"
     Site            order(580,583,603,606,609,612,634,637)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..647
                     /gene="SCEL"
                     /coded_by="XM_011535289.2:139..2082"
                     /db_xref="GeneID:8796"
                     /db_xref="HGNC:HGNC:10573"
                     /db_xref="MIM:604112"
ORIGIN      
        1 msnvtlrkms ptgnemkstt qgttrkqqdf hevnkrrtfl qdnswikkrp eeekdenygr
       61 vvlnrhnshd aldrkvnerd vpkatisrys sddtldrisd rndaaktyka ntldnqltnr
      121 smsmfrslev tklqpggsln antsntiast sattpvkkkr qswfpppppg ynassstgtr
      181 rrepgvhppi ppkpsspvss pnqlrqdnrq ihppkpgvyt etnrsaerni seeldnlikm
      241 nkslnraksl esliymstrt dkdgkgiqsl gspikvnqrt dknekgqnle svakvnarmn
      301 ktsrrsedld natevnpkgh enttgkkdld glikvdpetn knitrgqsld nlikvtpevk
      361 rsnqgskdln nfikvypgte ksteggqsld slikvtpern rtnqgnqdle nlikvipsan
      421 ksseqgldeh invspkavkn tdgkqdldkl ikvnpeiftn nqrnqdlanl ikvnpavirn
      481 nqsqdldnli kvkpsalrnt nrdqnlenli evnshvsenk ngssntgakq agpqdtvvyt
      541 rtyvensksp kdgyqenisg kyiqtvysts drsvierdmc tycrkplgve tkmildelqi
      601 cchstcfkce ickqplenlq agdsiwiyrq tihcepcysk imakwip
//
LOCUS       XP_047286669             645 aa            linear   PRI 05-AUG-2025
DEFINITION  sciellin isoform X18 [Homo sapiens].
ACCESSION   XP_047286669
VERSION     XP_047286669.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430713.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..645
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..645
                     /product="sciellin isoform X18"
                     /calculated_mol_wt=72536
     Region          577..635
                     /region_name="LIM"
                     /note="Zinc-binding domain present in Lin-11, Isl-1,
                     Mec-3; smart00132"
                     /db_xref="CDD:214528"
     Site            order(578,581,601,604,607,610,632,635)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..645
                     /gene="SCEL"
                     /coded_by="XM_047430713.1:139..2076"
                     /db_xref="GeneID:8796"
                     /db_xref="HGNC:HGNC:10573"
                     /db_xref="MIM:604112"
ORIGIN      
        1 msnvtlrkms ptgnemkstt qgttrkqqdf hevnkrrtfl qdnswikkrp eeekdenygr
       61 vvlnrhnshd aldrkvnerd vpkatisrys sddtldrsms mfrslevtkl qpggslnant
      121 sntiastsat tpvkkkrqsw fpppppgyna ssstgtrrre pgvhppippk psspvsspnq
      181 lrqdnrqihp pkpgvytetn rsaernirsq dldnivkvat slqrsdkgee ldnlikmnks
      241 lnrnqgldsl franpkveer ekrakslesl iymstrtdkd gkgiqslgsp ikvnqrtdkn
      301 ekgrqnlesv akvnarmnkt srrsedldna tevnpkghen ttggqsldnl ikvtpevkrs
      361 nqgskdlnnf ikvypgteks teggqsldsl ikvtpernrt nqgnqdlenl ikvipsanks
      421 seqgldehin vspkavkntd gkqdldklik vnpeiftnnq rnqdlanlik vnpavirnnq
      481 sqdldnlikv kpsalrntnr dqnlenliev nshvsenkng ssntgakqag pqdtvvytrt
      541 yvenskspkd gyqenisgky iqtvystsdr svierdmcty crkplgvetk mildelqicc
      601 hstcfkceic kqplenlqag dsiwiyrqti hcepcyskim akwip
//
LOCUS       XP_011533592             629 aa            linear   PRI 05-AUG-2025
DEFINITION  sciellin isoform X19 [Homo sapiens].
ACCESSION   XP_011533592
VERSION     XP_011533592.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535290.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..629
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..629
                     /product="sciellin isoform X19"
                     /calculated_mol_wt=70644
     Region          561..619
                     /region_name="LIM"
                     /note="Zinc-binding domain present in Lin-11, Isl-1,
                     Mec-3; smart00132"
                     /db_xref="CDD:214528"
     Site            order(562,565,585,588,591,594,616,619)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..629
                     /gene="SCEL"
                     /coded_by="XM_011535290.2:139..2028"
                     /db_xref="GeneID:8796"
                     /db_xref="HGNC:HGNC:10573"
                     /db_xref="MIM:604112"
ORIGIN      
        1 msnvtlrkms ptgnemkstt qgttrkqqdf hevnkrrtfl qdnswikkrp eeekdenygr
       61 vvlnrhnshd aldrkvnerd vpkatisrys sddtldrisd rndaaktyka ntldnqltnr
      121 smsmfrslev tklqpggsln antsntiast sattpvkkkr qswfpppppg ynassstgtr
      181 rrepgvhppi ppkpsspvss pnqlrqdnrq ihppkpgvyt etnrsaerni rsqdldnivk
      241 vatslqrsdk geeldnlikm nkslnrnqgl dslfranpkv eerekraksl esliymstrt
      301 dkdgkgiqsl gspikvnqrt dknekgrqnl esvakvnarm nktsrrsedl dnatevnpkg
      361 henttgkkdl dglikvdpet nknitrgqsl dnlikvtpev krsnqgskdl nnfikvypgt
      421 eksteggqsl dslikvtper nrtnqgnqdl enlikvipsa nksseqglde hinvspkavk
      481 ntdgdqnlen lievnshvse nkngssntga kqagpqdtvv ytrtyvensk spkdgyqeni
      541 sgkyiqtvys tsdrsvierd mctycrkplg vetkmildel qicchstcfk ceickqplen
      601 lqagdsiwiy rqtihcepcy skimakwip
//
LOCUS       XP_016876294             628 aa            linear   PRI 05-AUG-2025
DEFINITION  sciellin isoform X20 [Homo sapiens].
ACCESSION   XP_016876294
VERSION     XP_016876294.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020805.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..628
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..628
                     /product="sciellin isoform X20"
                     /calculated_mol_wt=70557
     Region          560..618
                     /region_name="LIM"
                     /note="Zinc-binding domain present in Lin-11, Isl-1,
                     Mec-3; smart00132"
                     /db_xref="CDD:214528"
     Site            order(561,564,584,587,590,593,615,618)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..628
                     /gene="SCEL"
                     /coded_by="XM_017020805.2:139..2025"
                     /db_xref="GeneID:8796"
                     /db_xref="HGNC:HGNC:10573"
                     /db_xref="MIM:604112"
ORIGIN      
        1 msnvtlrkms ptgnemkstt qgttrkqqdf hevnkrrtfl qdnswikkrp eeekdenygr
       61 vvlnrhnshd aldrkvnerd vpkatisrys sddtldrisd rndaaktyka ntldnqltnr
      121 smsmfrslev tklqpggsln antsntiast sattpvkkkr qswfpppppg ynassstgtr
      181 rrepgvhppi ppkpsspvss pnqlrqdnrq ihppkpgvyt etnrsaerni rsqdldnivk
      241 vatslqrsdk geeldnlikm nkslnrnqgl dslfranpkv eerekraksl esliymstrt
      301 dkdgkgiqsl gspikvnqrt dknekgrqnl esvakvnarm nktsrrsedl dnatevnpkg
      361 henttgkkdl dglikvdpet nknitrgqsl dnlikvtpev krsnqgskdl nnfikvypgt
      421 eksteggqsl dslikvtper nrtnqgnqdl enlikvipsa nkseqgldeh invspkavkn
      481 tdgdqnlenl ievnshvsen kngssntgak qagpqdtvvy trtyvensks pkdgyqenis
      541 gkyiqtvyst sdrsvierdm ctycrkplgv etkmildelq icchstcfkc eickqplenl
      601 qagdsiwiyr qtihcepcys kimakwip
//
LOCUS       XP_011533593             591 aa            linear   PRI 05-AUG-2025
DEFINITION  sciellin isoform X21 [Homo sapiens].
ACCESSION   XP_011533593
VERSION     XP_011533593.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535291.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..591
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..591
                     /product="sciellin isoform X21"
                     /calculated_mol_wt=66559
     Region          523..581
                     /region_name="LIM"
                     /note="Zinc-binding domain present in Lin-11, Isl-1,
                     Mec-3; smart00132"
                     /db_xref="CDD:214528"
     Site            order(524,527,547,550,553,556,578,581)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..591
                     /gene="SCEL"
                     /coded_by="XM_011535291.2:139..1914"
                     /db_xref="GeneID:8796"
                     /db_xref="HGNC:HGNC:10573"
                     /db_xref="MIM:604112"
ORIGIN      
        1 msnvtlrkms ptgnemkstt qgttrkqqdf hevnkrrtfl qdnswikkrp eeekdenygr
       61 vvlnrhnshd aldrkvnerd vpkatisrys sddtldrisd rndaaktyka ntldnqltnr
      121 smsmfrslev tklqpggsln antsntiast sattpvkkkr qswfpppppg ynassstgtr
      181 rrepgvhppi ppkpsspvss pnqlrqdnrq ihppkpgvyt etnrsaerni rsqdldnivk
      241 vatslqrsdk geeldnlikm nkslnrnqgl dslfranpkv eerekraksl esliymstrt
      301 dkdgkgiqsl gspikvnqrt dknekgrqnl esvakvnarm nktsrrsedl dnatevnpkg
      361 henttgkkdl dglikvdpet nknitrgqsl dnlikvtpev krsnqgskdl nnfikvypgt
      421 eksteggqsl dslikvtper nrtnqgdqnl enlievnshv senkngssnt gakqagpqdt
      481 vvytrtyven skspkdgyqe nisgkyiqtv ystsdrsvie rdmctycrkp lgvetkmild
      541 elqicchstc fkceickqpl enlqagdsiw iyrqtihcep cyskimakwi p
//
LOCUS       XP_047286670             571 aa            linear   PRI 05-AUG-2025
DEFINITION  sciellin isoform X22 [Homo sapiens].
ACCESSION   XP_047286670
VERSION     XP_047286670.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430714.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..571
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..571
                     /product="sciellin isoform X22"
                     /calculated_mol_wt=64279
     Region          503..561
                     /region_name="LIM"
                     /note="Zinc-binding domain present in Lin-11, Isl-1,
                     Mec-3; smart00132"
                     /db_xref="CDD:214528"
     Site            order(504,507,527,530,533,536,558,561)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..571
                     /gene="SCEL"
                     /coded_by="XM_047430714.1:139..1854"
                     /db_xref="GeneID:8796"
                     /db_xref="HGNC:HGNC:10573"
                     /db_xref="MIM:604112"
ORIGIN      
        1 msnvtlrkms ptgnemkstt qgttrkqqdf hevnkrrtfl qdnswikkrp eeekdenygr
       61 vvlnrhnshd aldrkvnerd vpkatisrys sddtldrisd rndaaktyka ntldnqltnr
      121 smsmfrslev tklqpggsln antsntiast sattpvkkkr qswfpppppg ynassstgtr
      181 rrepgvhppi ppkpsspvss pnqlrqdnrq ihppkpgvyt etnrsaerni rsqdldnivk
      241 vatslqrsdk geeldnlikm nkslnrnqgl dslfranpkv eerekraksl esliymstrt
      301 dkdgkgiqsl gspikvnqrt dknekgrqnl esvakvnarm nktsrrsedl dnatevnpkg
      361 henttggqsl dnlikvtpev krsnqgskdl nnfikvypgt eksteggqsl dslikvtper
      421 nrtnqgdqnl enlievnshv senkngssnt gakqagpqdt vvytrtyven skspkdgyqe
      481 nisgkyiqtv ystsdrsvie rdmctycrkp lgvetkmild elqicchstc fkceickqpl
      541 enlqagdsiw iyrqtihcep cyskimakwi p
//
LOCUS       XP_047286671            1073 aa            linear   PRI 05-AUG-2025
DEFINITION  TSC22 domain family protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047286671
VERSION     XP_047286671.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430715.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1073
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1073
                     /product="TSC22 domain family protein 1 isoform X1"
                     /calculated_mol_wt=109546
     Region          <685..899
                     /region_name="rne"
                     /note="ribonuclease E; Reviewed; PRK10811"
                     /db_xref="CDD:236766"
     Region          983..1061
                     /region_name="ZIP_TSC22D1"
                     /note="leucine zipper domain found in TSC22 domain family
                     protein 1; cd21938"
                     /db_xref="CDD:409278"
     Site            order(1001..1003,1006,1009..1010,1013..1014,1016..1017,
                     1020..1021,1023..1024,1027..1028,1031,1035)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:409278"
     CDS             1..1073
                     /gene="TSC22D1"
                     /gene_synonym="HUCEP-2; Ptg-2; TGFB1I4; TSC22"
                     /coded_by="XM_047430715.1:1083..4304"
                     /db_xref="GeneID:8848"
                     /db_xref="HGNC:HGNC:16826"
                     /db_xref="MIM:607715"
ORIGIN      
        1 mhqppestaa aaaaadisar kmahpamfpr rgsgsgsasa lnaagtgvgs natssedfpp
       61 psllqppppa asstsgpqpp ppqslnllsq aqlqaqplap ggtqmkkksg fqitsvtpaq
      121 isasissnns iaedtesydd ldeshtedls sseildvsls ratdlgeper ssseetlnnf
      181 qeaetpgavs pnqphlpqph lphlpqqnvv ingnahphhl hhhhqihhgh hlqhghhhps
      241 hvavasasit ggppsspvsr klsttgssds itpvaptsav sssgspasvm tnmrapsttg
      301 giginsvtgt stvnnvnita vgsfnpnvts smlgnvnist snipsaagvs vgpgvtsgvn
      361 vnilsgmgng tisssaavss vpnaaagmtg gsvssqqqqp tvntsrfrvv kldsssepfk
      421 kgrwtctefy ekenavpate gvlinkvvet vkqnpievts erestsgssv sssvstlshy
      481 tesvgsgemg aptvvvqqqq qqqqqqqqqp alqgvtlqqm dfgstgpqsi pavsipqsis
      541 qsqisqvqlq sqelsyqqkq glqpvplqat msaatgiqps pvnvvgvtsa lgqqpsissl
      601 aqpqlpysqa appvqtplpg apppqqlqyg qqqpmvstqm apghvksvtq npaseyvqqq
      661 pilqtamssg qpssagvgag ttvipvaqpq giqlpvqpta vpaqpagasv qpvgqapaav
      721 savptgsqia nigqqanipt avqqpstqvp psviqqgapp ssqvvppaqt giihqgvqts
      781 apslpqqlvi asqsslltvp pqpqgvepva qgivsqqlpa vsslpsassi svtsqvsstg
      841 psgmpsaptn lvppqniaqt patqngnlvq svsqppliat ntnlplaqqi plsstqfsaq
      901 slaqaigsqi edarraaeps lvglpqtisg dsggmsavsd gsssslaasa slfplkvlpl
      961 ttplvdgede sssgasvvai dnkieqamdl vkshlmyavr eevevlkeqi kelieknsql
     1021 eqennllktl aspeqlaqfq aqlqtgsppa ttqpqgttqp paqpasqgsg pta
//
LOCUS       XP_047286672            1073 aa            linear   PRI 05-AUG-2025
DEFINITION  TSC22 domain family protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047286672
VERSION     XP_047286672.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430716.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1073
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1073
                     /product="TSC22 domain family protein 1 isoform X1"
                     /calculated_mol_wt=109546
     Region          <685..899
                     /region_name="rne"
                     /note="ribonuclease E; Reviewed; PRK10811"
                     /db_xref="CDD:236766"
     Region          983..1061
                     /region_name="ZIP_TSC22D1"
                     /note="leucine zipper domain found in TSC22 domain family
                     protein 1; cd21938"
                     /db_xref="CDD:409278"
     Site            order(1001..1003,1006,1009..1010,1013..1014,1016..1017,
                     1020..1021,1023..1024,1027..1028,1031,1035)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:409278"
     CDS             1..1073
                     /gene="TSC22D1"
                     /gene_synonym="HUCEP-2; Ptg-2; TGFB1I4; TSC22"
                     /coded_by="XM_047430716.1:861..4082"
                     /db_xref="GeneID:8848"
                     /db_xref="HGNC:HGNC:16826"
                     /db_xref="MIM:607715"
ORIGIN      
        1 mhqppestaa aaaaadisar kmahpamfpr rgsgsgsasa lnaagtgvgs natssedfpp
       61 psllqppppa asstsgpqpp ppqslnllsq aqlqaqplap ggtqmkkksg fqitsvtpaq
      121 isasissnns iaedtesydd ldeshtedls sseildvsls ratdlgeper ssseetlnnf
      181 qeaetpgavs pnqphlpqph lphlpqqnvv ingnahphhl hhhhqihhgh hlqhghhhps
      241 hvavasasit ggppsspvsr klsttgssds itpvaptsav sssgspasvm tnmrapsttg
      301 giginsvtgt stvnnvnita vgsfnpnvts smlgnvnist snipsaagvs vgpgvtsgvn
      361 vnilsgmgng tisssaavss vpnaaagmtg gsvssqqqqp tvntsrfrvv kldsssepfk
      421 kgrwtctefy ekenavpate gvlinkvvet vkqnpievts erestsgssv sssvstlshy
      481 tesvgsgemg aptvvvqqqq qqqqqqqqqp alqgvtlqqm dfgstgpqsi pavsipqsis
      541 qsqisqvqlq sqelsyqqkq glqpvplqat msaatgiqps pvnvvgvtsa lgqqpsissl
      601 aqpqlpysqa appvqtplpg apppqqlqyg qqqpmvstqm apghvksvtq npaseyvqqq
      661 pilqtamssg qpssagvgag ttvipvaqpq giqlpvqpta vpaqpagasv qpvgqapaav
      721 savptgsqia nigqqanipt avqqpstqvp psviqqgapp ssqvvppaqt giihqgvqts
      781 apslpqqlvi asqsslltvp pqpqgvepva qgivsqqlpa vsslpsassi svtsqvsstg
      841 psgmpsaptn lvppqniaqt patqngnlvq svsqppliat ntnlplaqqi plsstqfsaq
      901 slaqaigsqi edarraaeps lvglpqtisg dsggmsavsd gsssslaasa slfplkvlpl
      961 ttplvdgede sssgasvvai dnkieqamdl vkshlmyavr eevevlkeqi kelieknsql
     1021 eqennllktl aspeqlaqfq aqlqtgsppa ttqpqgttqp paqpasqgsg pta
//
LOCUS       XP_016876299            1048 aa            linear   PRI 05-AUG-2025
DEFINITION  TSC22 domain family protein 1 isoform X2 [Homo sapiens].
ACCESSION   XP_016876299
VERSION     XP_016876299.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020810.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1048
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1048
                     /product="TSC22 domain family protein 1 isoform X2"
                     /calculated_mol_wt=107456
     Region          <564..784
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          <685..899
                     /region_name="rne"
                     /note="ribonuclease E; Reviewed; PRK10811"
                     /db_xref="CDD:236766"
     CDS             1..1048
                     /gene="TSC22D1"
                     /gene_synonym="HUCEP-2; Ptg-2; TGFB1I4; TSC22"
                     /coded_by="XM_017020810.3:257..3403"
                     /db_xref="GeneID:8848"
                     /db_xref="HGNC:HGNC:16826"
                     /db_xref="MIM:607715"
ORIGIN      
        1 mhqppestaa aaaaadisar kmahpamfpr rgsgsgsasa lnaagtgvgs natssedfpp
       61 psllqppppa asstsgpqpp ppqslnllsq aqlqaqplap ggtqmkkksg fqitsvtpaq
      121 isasissnns iaedtesydd ldeshtedls sseildvsls ratdlgeper ssseetlnnf
      181 qeaetpgavs pnqphlpqph lphlpqqnvv ingnahphhl hhhhqihhgh hlqhghhhps
      241 hvavasasit ggppsspvsr klsttgssds itpvaptsav sssgspasvm tnmrapsttg
      301 giginsvtgt stvnnvnita vgsfnpnvts smlgnvnist snipsaagvs vgpgvtsgvn
      361 vnilsgmgng tisssaavss vpnaaagmtg gsvssqqqqp tvntsrfrvv kldsssepfk
      421 kgrwtctefy ekenavpate gvlinkvvet vkqnpievts erestsgssv sssvstlshy
      481 tesvgsgemg aptvvvqqqq qqqqqqqqqp alqgvtlqqm dfgstgpqsi pavsipqsis
      541 qsqisqvqlq sqelsyqqkq glqpvplqat msaatgiqps pvnvvgvtsa lgqqpsissl
      601 aqpqlpysqa appvqtplpg apppqqlqyg qqqpmvstqm apghvksvtq npaseyvqqq
      661 pilqtamssg qpssagvgag ttvipvaqpq giqlpvqpta vpaqpagasv qpvgqapaav
      721 savptgsqia nigqqanipt avqqpstqvp psviqqgapp ssqvvppaqt giihqgvqts
      781 apslpqqlvi asqsslltvp pqpqgvepva qgivsqqlpa vsslpsassi svtsqvsstg
      841 psgmpsaptn lvppqniaqt patqngnlvq svsqppliat ntnlplaqqi plsstqfsaq
      901 slaqaigsqi edarraaeps lvglpqtisg dsggmsavsd gsssslaasa slfplkvlpl
      961 ttplvdgede sasllpevqg vilepqiqpr prrafdvrgp lsplnpwrqn iqllervgkd
     1021 nkqvgafhyl lgliyrlecp siahlilw
//
LOCUS       XP_047286673            1028 aa            linear   PRI 05-AUG-2025
DEFINITION  TSC22 domain family protein 1 isoform X3 [Homo sapiens].
ACCESSION   XP_047286673
VERSION     XP_047286673.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430717.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1028
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1028
                     /product="TSC22 domain family protein 1 isoform X3"
                     /calculated_mol_wt=105223
     Region          <685..899
                     /region_name="rne"
                     /note="ribonuclease E; Reviewed; PRK10811"
                     /db_xref="CDD:236766"
     CDS             1..1028
                     /gene="TSC22D1"
                     /gene_synonym="HUCEP-2; Ptg-2; TGFB1I4; TSC22"
                     /coded_by="XM_047430717.1:1083..4169"
                     /db_xref="GeneID:8848"
                     /db_xref="HGNC:HGNC:16826"
                     /db_xref="MIM:607715"
ORIGIN      
        1 mhqppestaa aaaaadisar kmahpamfpr rgsgsgsasa lnaagtgvgs natssedfpp
       61 psllqppppa asstsgpqpp ppqslnllsq aqlqaqplap ggtqmkkksg fqitsvtpaq
      121 isasissnns iaedtesydd ldeshtedls sseildvsls ratdlgeper ssseetlnnf
      181 qeaetpgavs pnqphlpqph lphlpqqnvv ingnahphhl hhhhqihhgh hlqhghhhps
      241 hvavasasit ggppsspvsr klsttgssds itpvaptsav sssgspasvm tnmrapsttg
      301 giginsvtgt stvnnvnita vgsfnpnvts smlgnvnist snipsaagvs vgpgvtsgvn
      361 vnilsgmgng tisssaavss vpnaaagmtg gsvssqqqqp tvntsrfrvv kldsssepfk
      421 kgrwtctefy ekenavpate gvlinkvvet vkqnpievts erestsgssv sssvstlshy
      481 tesvgsgemg aptvvvqqqq qqqqqqqqqp alqgvtlqqm dfgstgpqsi pavsipqsis
      541 qsqisqvqlq sqelsyqqkq glqpvplqat msaatgiqps pvnvvgvtsa lgqqpsissl
      601 aqpqlpysqa appvqtplpg apppqqlqyg qqqpmvstqm apghvksvtq npaseyvqqq
      661 pilqtamssg qpssagvgag ttvipvaqpq giqlpvqpta vpaqpagasv qpvgqapaav
      721 savptgsqia nigqqanipt avqqpstqvp psviqqgapp ssqvvppaqt giihqgvqts
      781 apslpqqlvi asqsslltvp pqpqgvepva qgivsqqlpa vsslpsassi svtsqvsstg
      841 psgmpsaptn lvppqniaqt patqngnlvq svsqppliat ntnlplaqqi plsstqfsaq
      901 slaqaigsqi edarraaeps lvglpqtisg dsggmsavsd gsssslaasa slfplkvlpl
      961 ttplvdgede sasllpevqg vilepqiqpr prrafdvrgp lsplnpwrqn iqllervgkd
     1021 nkqisfnw
//
LOCUS       XP_047286674            1028 aa            linear   PRI 05-AUG-2025
DEFINITION  TSC22 domain family protein 1 isoform X3 [Homo sapiens].
ACCESSION   XP_047286674
VERSION     XP_047286674.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430718.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1028
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1028
                     /product="TSC22 domain family protein 1 isoform X3"
                     /calculated_mol_wt=105223
     Region          <685..899
                     /region_name="rne"
                     /note="ribonuclease E; Reviewed; PRK10811"
                     /db_xref="CDD:236766"
     CDS             1..1028
                     /gene="TSC22D1"
                     /gene_synonym="HUCEP-2; Ptg-2; TGFB1I4; TSC22"
                     /coded_by="XM_047430718.1:861..3947"
                     /db_xref="GeneID:8848"
                     /db_xref="HGNC:HGNC:16826"
                     /db_xref="MIM:607715"
ORIGIN      
        1 mhqppestaa aaaaadisar kmahpamfpr rgsgsgsasa lnaagtgvgs natssedfpp
       61 psllqppppa asstsgpqpp ppqslnllsq aqlqaqplap ggtqmkkksg fqitsvtpaq
      121 isasissnns iaedtesydd ldeshtedls sseildvsls ratdlgeper ssseetlnnf
      181 qeaetpgavs pnqphlpqph lphlpqqnvv ingnahphhl hhhhqihhgh hlqhghhhps
      241 hvavasasit ggppsspvsr klsttgssds itpvaptsav sssgspasvm tnmrapsttg
      301 giginsvtgt stvnnvnita vgsfnpnvts smlgnvnist snipsaagvs vgpgvtsgvn
      361 vnilsgmgng tisssaavss vpnaaagmtg gsvssqqqqp tvntsrfrvv kldsssepfk
      421 kgrwtctefy ekenavpate gvlinkvvet vkqnpievts erestsgssv sssvstlshy
      481 tesvgsgemg aptvvvqqqq qqqqqqqqqp alqgvtlqqm dfgstgpqsi pavsipqsis
      541 qsqisqvqlq sqelsyqqkq glqpvplqat msaatgiqps pvnvvgvtsa lgqqpsissl
      601 aqpqlpysqa appvqtplpg apppqqlqyg qqqpmvstqm apghvksvtq npaseyvqqq
      661 pilqtamssg qpssagvgag ttvipvaqpq giqlpvqpta vpaqpagasv qpvgqapaav
      721 savptgsqia nigqqanipt avqqpstqvp psviqqgapp ssqvvppaqt giihqgvqts
      781 apslpqqlvi asqsslltvp pqpqgvepva qgivsqqlpa vsslpsassi svtsqvsstg
      841 psgmpsaptn lvppqniaqt patqngnlvq svsqppliat ntnlplaqqi plsstqfsaq
      901 slaqaigsqi edarraaeps lvglpqtisg dsggmsavsd gsssslaasa slfplkvlpl
      961 ttplvdgede sasllpevqg vilepqiqpr prrafdvrgp lsplnpwrqn iqllervgkd
     1021 nkqisfnw
//
LOCUS       XP_047286675             999 aa            linear   PRI 05-AUG-2025
DEFINITION  TSC22 domain family protein 1 isoform X4 [Homo sapiens].
ACCESSION   XP_047286675
VERSION     XP_047286675.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430719.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..999
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..999
                     /product="TSC22 domain family protein 1 isoform X4"
                     /calculated_mol_wt=101715
     Region          <685..899
                     /region_name="rne"
                     /note="ribonuclease E; Reviewed; PRK10811"
                     /db_xref="CDD:236766"
     CDS             1..999
                     /gene="TSC22D1"
                     /gene_synonym="HUCEP-2; Ptg-2; TGFB1I4; TSC22"
                     /coded_by="XM_047430719.1:861..3860"
                     /db_xref="GeneID:8848"
                     /db_xref="HGNC:HGNC:16826"
                     /db_xref="MIM:607715"
ORIGIN      
        1 mhqppestaa aaaaadisar kmahpamfpr rgsgsgsasa lnaagtgvgs natssedfpp
       61 psllqppppa asstsgpqpp ppqslnllsq aqlqaqplap ggtqmkkksg fqitsvtpaq
      121 isasissnns iaedtesydd ldeshtedls sseildvsls ratdlgeper ssseetlnnf
      181 qeaetpgavs pnqphlpqph lphlpqqnvv ingnahphhl hhhhqihhgh hlqhghhhps
      241 hvavasasit ggppsspvsr klsttgssds itpvaptsav sssgspasvm tnmrapsttg
      301 giginsvtgt stvnnvnita vgsfnpnvts smlgnvnist snipsaagvs vgpgvtsgvn
      361 vnilsgmgng tisssaavss vpnaaagmtg gsvssqqqqp tvntsrfrvv kldsssepfk
      421 kgrwtctefy ekenavpate gvlinkvvet vkqnpievts erestsgssv sssvstlshy
      481 tesvgsgemg aptvvvqqqq qqqqqqqqqp alqgvtlqqm dfgstgpqsi pavsipqsis
      541 qsqisqvqlq sqelsyqqkq glqpvplqat msaatgiqps pvnvvgvtsa lgqqpsissl
      601 aqpqlpysqa appvqtplpg apppqqlqyg qqqpmvstqm apghvksvtq npaseyvqqq
      661 pilqtamssg qpssagvgag ttvipvaqpq giqlpvqpta vpaqpagasv qpvgqapaav
      721 savptgsqia nigqqanipt avqqpstqvp psviqqgapp ssqvvppaqt giihqgvqts
      781 apslpqqlvi asqsslltvp pqpqgvepva qgivsqqlpa vsslpsassi svtsqvsstg
      841 psgmpsaptn lvppqniaqt patqngnlvq svsqppliat ntnlplaqqi plsstqfsaq
      901 slaqaigsqi edarraaeps lvglpqtisg dsggmsavsd gsssslaasa slfplkvlpl
      961 ttplvdgede sslfqcfspt rgarsdprtt dtakttesf
//
LOCUS       XP_016876300             985 aa            linear   PRI 05-AUG-2025
DEFINITION  TSC22 domain family protein 1 isoform X5 [Homo sapiens].
ACCESSION   XP_016876300
VERSION     XP_016876300.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020811.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..985
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..985
                     /product="TSC22 domain family protein 1 isoform X5"
                     /calculated_mol_wt=100359
     Region          <685..899
                     /region_name="rne"
                     /note="ribonuclease E; Reviewed; PRK10811"
                     /db_xref="CDD:236766"
     CDS             1..985
                     /gene="TSC22D1"
                     /gene_synonym="HUCEP-2; Ptg-2; TGFB1I4; TSC22"
                     /coded_by="XM_017020811.3:257..3214"
                     /db_xref="GeneID:8848"
                     /db_xref="HGNC:HGNC:16826"
                     /db_xref="MIM:607715"
ORIGIN      
        1 mhqppestaa aaaaadisar kmahpamfpr rgsgsgsasa lnaagtgvgs natssedfpp
       61 psllqppppa asstsgpqpp ppqslnllsq aqlqaqplap ggtqmkkksg fqitsvtpaq
      121 isasissnns iaedtesydd ldeshtedls sseildvsls ratdlgeper ssseetlnnf
      181 qeaetpgavs pnqphlpqph lphlpqqnvv ingnahphhl hhhhqihhgh hlqhghhhps
      241 hvavasasit ggppsspvsr klsttgssds itpvaptsav sssgspasvm tnmrapsttg
      301 giginsvtgt stvnnvnita vgsfnpnvts smlgnvnist snipsaagvs vgpgvtsgvn
      361 vnilsgmgng tisssaavss vpnaaagmtg gsvssqqqqp tvntsrfrvv kldsssepfk
      421 kgrwtctefy ekenavpate gvlinkvvet vkqnpievts erestsgssv sssvstlshy
      481 tesvgsgemg aptvvvqqqq qqqqqqqqqp alqgvtlqqm dfgstgpqsi pavsipqsis
      541 qsqisqvqlq sqelsyqqkq glqpvplqat msaatgiqps pvnvvgvtsa lgqqpsissl
      601 aqpqlpysqa appvqtplpg apppqqlqyg qqqpmvstqm apghvksvtq npaseyvqqq
      661 pilqtamssg qpssagvgag ttvipvaqpq giqlpvqpta vpaqpagasv qpvgqapaav
      721 savptgsqia nigqqanipt avqqpstqvp psviqqgapp ssqvvppaqt giihqgvqts
      781 apslpqqlvi asqsslltvp pqpqgvepva qgivsqqlpa vsslpsassi svtsqvsstg
      841 psgmpsaptn lvppqniaqt patqngnlvq svsqppliat ntnlplaqqi plsstqfsaq
      901 slaqaigsqi edarraaeps lvglpqtisg dsggmsavsd gsssslaasa slfplkvlpl
      961 ttplvdgede sfwyisklag rarrk
//
LOCUS       XP_016876302             334 aa            linear   PRI 05-AUG-2025
DEFINITION  vitamin K-dependent protein Z isoform X1 [Homo sapiens].
ACCESSION   XP_016876302
VERSION     XP_016876302.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020813.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..334
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..334
                     /product="vitamin K-dependent protein Z isoform X1"
                     /calculated_mol_wt=37385
     Region          44..108
                     /region_name="GLA"
                     /note="Domain containing Gla (gamma-carboxyglutamate)
                     residues; smart00069"
                     /db_xref="CDD:214503"
     Region          <117..145
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          158..187
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          211..>311
                     /region_name="Tryp_SPc"
                     /note="Trypsin-like serine protease; Many of these are
                     synthesized as inactive precursor zymogens that are
                     cleaved during limited proteolysis to generate their
                     active forms. Alignment contains also inactive enzymes
                     that have substitutions of the catalytic triad...;
                     cl21584"
                     /db_xref="CDD:473915"
     CDS             1..334
                     /gene="PROZ"
                     /gene_synonym="PZ"
                     /coded_by="XM_017020813.2:14..1018"
                     /db_xref="GeneID:8858"
                     /db_xref="HGNC:HGNC:9460"
                     /db_xref="MIM:176895"
ORIGIN      
        1 magcvpllqg lvlvlalhrv epsatslker hglhsdsact gvqeslflpa skandvlvrw
       61 kragsyllee lfegnlekec yeeicvyeea revfenevvt defwrrykgg spcisqpclh
      121 ngscqdsiwg ytctcspgye gsncelakne chpertdgcq hfclpgqesy tcscaqgyrl
      181 gedhkqcvph dqcacgvlts ekrapdlqdl pwqvkltnse gkdfcggvii renfvlttak
      241 csllhrnitv ktyfnrtsqd plmikithvh vhmrydadag endlsllele wpiqcpgptv
      301 reaawrpctg wmevwspent eapgfsrgsw arsq
//
LOCUS       XP_047286676             236 aa            linear   PRI 05-AUG-2025
DEFINITION  vitamin K-dependent protein Z isoform X2 [Homo sapiens].
ACCESSION   XP_047286676
VERSION     XP_047286676.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430720.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..236
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..236
                     /product="vitamin K-dependent protein Z isoform X2"
                     /calculated_mol_wt=26076
     Region          44..108
                     /region_name="GLA"
                     /note="Domain containing Gla (gamma-carboxyglutamate)
                     residues; smart00069"
                     /db_xref="CDD:214503"
     Region          <117..145
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          158..187
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     CDS             1..236
                     /gene="PROZ"
                     /gene_synonym="PZ"
                     /coded_by="XM_047430720.1:14..724"
                     /db_xref="GeneID:8858"
                     /db_xref="HGNC:HGNC:9460"
                     /db_xref="MIM:176895"
ORIGIN      
        1 magcvpllqg lvlvlalhrv epsatslker hglhsdsact gvqeslflpa skandvlvrw
       61 kragsyllee lfegnlekec yeeicvyeea revfenevvt defwrrykgg spcisqpclh
      121 ngscqdsiwg ytctcspgye gsncelakne chpertdgcq hfclpgqesy tcscaqgyrl
      181 gedhkqcvph dqcacgvlts ekrapdlqdl pwqasntiis clsisfrtal snrnav
//
LOCUS       XP_047286677             214 aa            linear   PRI 05-AUG-2025
DEFINITION  vitamin K-dependent protein Z isoform X3 [Homo sapiens].
ACCESSION   XP_047286677
VERSION     XP_047286677.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430721.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..214
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..214
                     /product="vitamin K-dependent protein Z isoform X3"
                     /calculated_mol_wt=23767
     Region          22..86
                     /region_name="GLA"
                     /note="Domain containing Gla (gamma-carboxyglutamate)
                     residues; smart00069"
                     /db_xref="CDD:214503"
     Region          <95..123
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          136..165
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     CDS             1..214
                     /gene="PROZ"
                     /gene_synonym="PZ"
                     /coded_by="XM_047430721.1:14..658"
                     /db_xref="GeneID:8858"
                     /db_xref="HGNC:HGNC:9460"
                     /db_xref="MIM:176895"
ORIGIN      
        1 magcvpllqg lvlvlalhrv epsvflpask andvlvrwkr agsylleelf egnlekecye
       61 eicvyeeare vfenevvtde fwrrykggsp cisqpclhng scqdsiwgyt ctcspgyegs
      121 ncelaknech pertdgcqhf clpgqesytc scaqgyrlge dhkqcvphdq cacgvltsek
      181 rapdlqdlpw qasntiiscl sisfrtalsn rnav
//
LOCUS       XP_047286678             874 aa            linear   PRI 05-AUG-2025
DEFINITION  rho guanine nucleotide exchange factor 7 isoform X1 [Homo sapiens].
ACCESSION   XP_047286678
VERSION     XP_047286678.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430722.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..874
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..874
                     /product="rho guanine nucleotide exchange factor 7 isoform
                     X1"
                     /calculated_mol_wt=98379
     Region          3..115
                     /region_name="CH_betaPIX"
                     /note="calponin homology (CH) domain found in beta-Pak
                     Interactive eXchange factor; cd21266"
                     /db_xref="CDD:409115"
     Site            order(3,7,65,67..68,71..72,74,82..90,96,98..99,101..102,
                     105..106,109)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409115"
     Region          117..163
                     /region_name="RhoGEF67_u1"
                     /note="Unstructured region one on RhoGEF 6 and 7;
                     pfam16615"
                     /db_xref="CDD:465201"
     Region          167..220
                     /region_name="SH3_betaPIX"
                     /note="Src Homology 3 domain of beta-Pak Interactive
                     eXchange factor; cd12061"
                     /db_xref="CDD:212994"
     Site            order(172,174,177,180..181,196,198..200,211,213,215..216)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212994"
     Region          251..428
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
                     (DH) domain. It appears that PH domains invariably occur
                     C-terminal to RhoGEF/DH domains; cd00160"
                     /db_xref="CDD:238091"
     Site            order(257,261,355,379..380,383..384,386..387,390..391,
                     394..395,398,424,428)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          459..557
                     /region_name="PH_Cool_Pix"
                     /note="Cloned out of library/PAK-interactive exchange
                     factor pleckstrin homology (PH) domain; cd01225"
                     /db_xref="CDD:269932"
     Region          <564..647
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          617..719
                     /region_name="RhoGEF67_u2"
                     /note="Unstructured region two on RhoGEF 6 and 7;
                     pfam16614"
                     /db_xref="CDD:465200"
     Region          789..873
                     /region_name="betaPIX_CC"
                     /note="betaPIX coiled coil; pfam16523"
                     /db_xref="CDD:465158"
     CDS             1..874
                     /gene="ARHGEF7"
                     /gene_synonym="BETA-PIX; COOL-1; COOL1; Nbla10314; P50;
                     P50BP; P85; P85COOL1; P85SPR; PAK3; PIXB"
                     /coded_by="XM_047430722.1:909..3533"
                     /db_xref="GeneID:8874"
                     /db_xref="HGNC:HGNC:15607"
                     /db_xref="MIM:605477"
ORIGIN      
        1 mnsaeqtvtw litlgvlesp kktisdpegf lqaslkdgvv lcrllerllp gtiekvypep
       61 rseseclsni reflrgcgas lrletfdand lyqgqnfnkv lsslvtlnkv tadiglgsds
      121 vcarpsshri ksfdslgsqs lhtrtsklfq gqyrsldmtd nsnnqlvvra kfnfqqtned
      181 elsfskgdvi hvtrveeggw wegtlngrtg wfpsnyvrev kasekpvspk sgtlksppkg
      241 fdttainksy ynvvlqnile teneyskelq tvlstylrpl qtseklssan isylmgnlee
      301 icsfqqmlvq sleectklpe aqqrvggcfl nlmpqmktly ltycanhpsa vnvltehsee
      361 lgefmetkga sspgilvltt glskpfmrld kyptllkele rhmedyhtdr qdiqksmaaf
      421 knlsaqcqev rkrkelelqi lteairnweg ddiktlgnvt ymsqvliqca gseekneryl
      481 llfpnvllml sasprmsgfi yqgklpttgm titkledsen hrnafeisgs mierilvscn
      541 nqqdlqewve hlqkqtkvts vgnptikphs vpshtlpshp vtpsskhads kpapltpayh
      601 tlphpshhgt phttinwgpl eppktpkpws lsclrpappl rpsaalcyke vrsldhsnsq
      661 mtdlskspkt mkkllpkrkp erkpsdeefa srkstaalee daqilkviea yctsaktrqt
      721 lnstwqgtdl mhnhvladdd qpsldslgrr sslsrlepsd lsedsdydsi wtahsyrmgs
      781 tsrsrkesap qvllpeeeki iveetksngq tvieekslvd tvyalkdevq elrqdnkkmk
      841 ksleeeqrar kdleklvrkv lknmndpawd etnl
//
LOCUS       XP_047286679             845 aa            linear   PRI 05-AUG-2025
DEFINITION  rho guanine nucleotide exchange factor 7 isoform X2 [Homo sapiens].
ACCESSION   XP_047286679
VERSION     XP_047286679.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430723.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..845
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..845
                     /product="rho guanine nucleotide exchange factor 7 isoform
                     X2"
                     /calculated_mol_wt=95085
     Region          3..86
                     /region_name="CH_SF"
                     /note="calponin homology (CH) domain superfamily; cl00030"
                     /db_xref="CDD:469584"
     Region          88..134
                     /region_name="RhoGEF67_u1"
                     /note="Unstructured region one on RhoGEF 6 and 7;
                     pfam16615"
                     /db_xref="CDD:465201"
     Region          138..191
                     /region_name="SH3_betaPIX"
                     /note="Src Homology 3 domain of beta-Pak Interactive
                     eXchange factor; cd12061"
                     /db_xref="CDD:212994"
     Site            order(143,145,148,151..152,167,169..171,182,184,186..187)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212994"
     Region          222..399
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
                     (DH) domain. It appears that PH domains invariably occur
                     C-terminal to RhoGEF/DH domains; cd00160"
                     /db_xref="CDD:238091"
     Site            order(228,232,326,350..351,354..355,357..358,361..362,
                     365..366,369,395,399)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          430..528
                     /region_name="PH_Cool_Pix"
                     /note="Cloned out of library/PAK-interactive exchange
                     factor pleckstrin homology (PH) domain; cd01225"
                     /db_xref="CDD:269932"
     Region          <535..618
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          588..690
                     /region_name="RhoGEF67_u2"
                     /note="Unstructured region two on RhoGEF 6 and 7;
                     pfam16614"
                     /db_xref="CDD:465200"
     Region          760..844
                     /region_name="betaPIX_CC"
                     /note="betaPIX coiled coil; pfam16523"
                     /db_xref="CDD:465158"
     CDS             1..845
                     /gene="ARHGEF7"
                     /gene_synonym="BETA-PIX; COOL-1; COOL1; Nbla10314; P50;
                     P50BP; P85; P85COOL1; P85SPR; PAK3; PIXB"
                     /coded_by="XM_047430723.1:909..3446"
                     /db_xref="GeneID:8874"
                     /db_xref="HGNC:HGNC:15607"
                     /db_xref="MIM:605477"
ORIGIN      
        1 mnsaeqtvtw litlgvlesp kktisdpegf lqaslkdgvv lcrllerllp gtiektfdan
       61 dlyqgqnfnk vlsslvtlnk vtadiglgsd svcarpsshr iksfdslgsq slhtrtsklf
      121 qgqyrsldmt dnsnnqlvvr akfnfqqtne delsfskgdv ihvtrveegg wwegtlngrt
      181 gwfpsnyvre vkasekpvsp ksgtlksppk gfdttainks yynvvlqnil eteneyskel
      241 qtvlstylrp lqtseklssa nisylmgnle eicsfqqmlv qsleectklp eaqqrvggcf
      301 lnlmpqmktl yltycanhps avnvltehse elgefmetkg asspgilvlt tglskpfmrl
      361 dkyptllkel erhmedyhtd rqdiqksmaa fknlsaqcqe vrkrkelelq ilteairnwe
      421 gddiktlgnv tymsqvliqc agseeknery lllfpnvllm lsasprmsgf iyqgklpttg
      481 mtitkledse nhrnafeisg smierilvsc nnqqdlqewv ehlqkqtkvt svgnptikph
      541 svpshtlpsh pvtpsskhad skpapltpay htlphpshhg tphttinwgp leppktpkpw
      601 slsclrpapp lrpsaalcyk evrsldhsns qmtdlskspk tmkkllpkrk perkpsdeef
      661 asrkstaale edaqilkvie ayctsaktrq tlnstwqgtd lmhnhvladd dqpsldslgr
      721 rsslsrleps dlsedsdyds iwtahsyrmg stsrsrkesa pqvllpeeek iiveetksng
      781 qtvieekslv dtvyalkdev qelrqdnkkm kksleeeqra rkdleklvrk vlknmndpaw
      841 detnl
//
LOCUS       XP_047286680             833 aa            linear   PRI 05-AUG-2025
DEFINITION  rho guanine nucleotide exchange factor 7 isoform X3 [Homo sapiens].
ACCESSION   XP_047286680
VERSION     XP_047286680.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430724.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..833
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..833
                     /product="rho guanine nucleotide exchange factor 7 isoform
                     X3"
                     /calculated_mol_wt=93729
     Region          3..86
                     /region_name="CH_SF"
                     /note="calponin homology (CH) domain superfamily; cl00030"
                     /db_xref="CDD:469584"
     Region          88..134
                     /region_name="RhoGEF67_u1"
                     /note="Unstructured region one on RhoGEF 6 and 7;
                     pfam16615"
                     /db_xref="CDD:465201"
     Region          138..191
                     /region_name="SH3_betaPIX"
                     /note="Src Homology 3 domain of beta-Pak Interactive
                     eXchange factor; cd12061"
                     /db_xref="CDD:212994"
     Site            order(143,145,148,151..152,167,169..171,182,184,186..187)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212994"
     Region          222..399
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
                     (DH) domain. It appears that PH domains invariably occur
                     C-terminal to RhoGEF/DH domains; cd00160"
                     /db_xref="CDD:238091"
     Site            order(228,232,326,350..351,354..355,357..358,361..362,
                     365..366,369,395,399)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          430..528
                     /region_name="PH_Cool_Pix"
                     /note="Cloned out of library/PAK-interactive exchange
                     factor pleckstrin homology (PH) domain; cd01225"
                     /db_xref="CDD:269932"
     Region          588..678
                     /region_name="RhoGEF67_u2"
                     /note="Unstructured region two on RhoGEF 6 and 7;
                     pfam16614"
                     /db_xref="CDD:465200"
     Region          748..832
                     /region_name="betaPIX_CC"
                     /note="betaPIX coiled coil; pfam16523"
                     /db_xref="CDD:465158"
     CDS             1..833
                     /gene="ARHGEF7"
                     /gene_synonym="BETA-PIX; COOL-1; COOL1; Nbla10314; P50;
                     P50BP; P85; P85COOL1; P85SPR; PAK3; PIXB"
                     /coded_by="XM_047430724.1:909..3410"
                     /db_xref="GeneID:8874"
                     /db_xref="HGNC:HGNC:15607"
                     /db_xref="MIM:605477"
ORIGIN      
        1 mnsaeqtvtw litlgvlesp kktisdpegf lqaslkdgvv lcrllerllp gtiektfdan
       61 dlyqgqnfnk vlsslvtlnk vtadiglgsd svcarpsshr iksfdslgsq slhtrtsklf
      121 qgqyrsldmt dnsnnqlvvr akfnfqqtne delsfskgdv ihvtrveegg wwegtlngrt
      181 gwfpsnyvre vkasekpvsp ksgtlksppk gfdttainks yynvvlqnil eteneyskel
      241 qtvlstylrp lqtseklssa nisylmgnle eicsfqqmlv qsleectklp eaqqrvggcf
      301 lnlmpqmktl yltycanhps avnvltehse elgefmetkg asspgilvlt tglskpfmrl
      361 dkyptllkel erhmedyhtd rqdiqksmaa fknlsaqcqe vrkrkelelq ilteairnwe
      421 gddiktlgnv tymsqvliqc agseeknery lllfpnvllm lsasprmsgf iyqgklpttg
      481 mtitkledse nhrnafeisg smierilvsc nnqqdlqewv ehlqkqtkvt svgnptikph
      541 svpshtlpsh pvtpsskhad skpapltpay htlphpshhg tphttinwgp leppktpkpw
      601 slsclrpapp lrpsaalcyk edlskspktm kkllpkrkpe rkpsdeefas rkstaaleed
      661 aqilkvieay ctsaktrqtl nstwqgtdlm hnhvladddq psldslgrrs slsrlepsdl
      721 sedsdydsiw tahsyrmgst srsrkesapq vllpeeekii veetksngqt vieekslvdt
      781 vyalkdevqe lrqdnkkmkk sleeeqrark dleklvrkvl knmndpawde tnl
//
LOCUS       XP_006720019             815 aa            linear   PRI 05-AUG-2025
DEFINITION  rho guanine nucleotide exchange factor 7 isoform X4 [Homo sapiens].
ACCESSION   XP_006720019
VERSION     XP_006720019.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006719956.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..815
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..815
                     /product="rho guanine nucleotide exchange factor 7 isoform
                     X4"
                     /calculated_mol_wt=91687
     Region          3..115
                     /region_name="CH_betaPIX"
                     /note="calponin homology (CH) domain found in beta-Pak
                     Interactive eXchange factor; cd21266"
                     /db_xref="CDD:409115"
     Site            order(3,7,65,67..68,71..72,74,82..90,96,98..99,101..102,
                     105..106,109)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409115"
     Region          117..163
                     /region_name="RhoGEF67_u1"
                     /note="Unstructured region one on RhoGEF 6 and 7;
                     pfam16615"
                     /db_xref="CDD:465201"
     Region          167..220
                     /region_name="SH3_betaPIX"
                     /note="Src Homology 3 domain of beta-Pak Interactive
                     eXchange factor; cd12061"
                     /db_xref="CDD:212994"
     Site            order(172,174,177,180..181,196,198..200,211,213,215..216)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212994"
     Region          251..428
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
                     (DH) domain. It appears that PH domains invariably occur
                     C-terminal to RhoGEF/DH domains; cd00160"
                     /db_xref="CDD:238091"
     Site            order(257,261,355,379..380,383..384,386..387,390..391,
                     394..395,398,424,428)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          459..557
                     /region_name="PH_Cool_Pix"
                     /note="Cloned out of library/PAK-interactive exchange
                     factor pleckstrin homology (PH) domain; cd01225"
                     /db_xref="CDD:269932"
     Region          <564..647
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          617..719
                     /region_name="RhoGEF67_u2"
                     /note="Unstructured region two on RhoGEF 6 and 7;
                     pfam16614"
                     /db_xref="CDD:465200"
     Region          730..814
                     /region_name="betaPIX_CC"
                     /note="betaPIX coiled coil; pfam16523"
                     /db_xref="CDD:465158"
     CDS             1..815
                     /gene="ARHGEF7"
                     /gene_synonym="BETA-PIX; COOL-1; COOL1; Nbla10314; P50;
                     P50BP; P85; P85COOL1; P85SPR; PAK3; PIXB"
                     /coded_by="XM_006719956.4:909..3356"
                     /db_xref="GeneID:8874"
                     /db_xref="HGNC:HGNC:15607"
                     /db_xref="MIM:605477"
ORIGIN      
        1 mnsaeqtvtw litlgvlesp kktisdpegf lqaslkdgvv lcrllerllp gtiekvypep
       61 rseseclsni reflrgcgas lrletfdand lyqgqnfnkv lsslvtlnkv tadiglgsds
      121 vcarpsshri ksfdslgsqs lhtrtsklfq gqyrsldmtd nsnnqlvvra kfnfqqtned
      181 elsfskgdvi hvtrveeggw wegtlngrtg wfpsnyvrev kasekpvspk sgtlksppkg
      241 fdttainksy ynvvlqnile teneyskelq tvlstylrpl qtseklssan isylmgnlee
      301 icsfqqmlvq sleectklpe aqqrvggcfl nlmpqmktly ltycanhpsa vnvltehsee
      361 lgefmetkga sspgilvltt glskpfmrld kyptllkele rhmedyhtdr qdiqksmaaf
      421 knlsaqcqev rkrkelelqi lteairnweg ddiktlgnvt ymsqvliqca gseekneryl
      481 llfpnvllml sasprmsgfi yqgklpttgm titkledsen hrnafeisgs mierilvscn
      541 nqqdlqewve hlqkqtkvts vgnptikphs vpshtlpshp vtpsskhads kpapltpayh
      601 tlphpshhgt phttinwgpl eppktpkpws lsclrpappl rpsaalcyke vrsldhsnsq
      661 mtdlskspkt mkkllpkrkp erkpsdeefa srkstaalee daqilkviea yctsaktrqt
      721 lnsssrkesa pqvllpeeek iiveetksng qtvieekslv dtvyalkdev qelrqdnkkm
      781 kksleeeqra rkdleklvrk vlknmndpaw detnl
//
LOCUS       XP_047286681             813 aa            linear   PRI 05-AUG-2025
DEFINITION  rho guanine nucleotide exchange factor 7 isoform X5 [Homo sapiens].
ACCESSION   XP_047286681
VERSION     XP_047286681.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430725.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..813
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..813
                     /product="rho guanine nucleotide exchange factor 7 isoform
                     X5"
                     /calculated_mol_wt=91608
     Region          <18..54
                     /region_name="CH_SF"
                     /note="calponin homology (CH) domain superfamily; cl00030"
                     /db_xref="CDD:469584"
     Region          56..102
                     /region_name="RhoGEF67_u1"
                     /note="Unstructured region one on RhoGEF 6 and 7;
                     pfam16615"
                     /db_xref="CDD:465201"
     Region          106..159
                     /region_name="SH3_betaPIX"
                     /note="Src Homology 3 domain of beta-Pak Interactive
                     eXchange factor; cd12061"
                     /db_xref="CDD:212994"
     Site            order(111,113,116,119..120,135,137..139,150,152,154..155)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212994"
     Region          190..367
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
                     (DH) domain. It appears that PH domains invariably occur
                     C-terminal to RhoGEF/DH domains; cd00160"
                     /db_xref="CDD:238091"
     Site            order(196,200,294,318..319,322..323,325..326,329..330,
                     333..334,337,363,367)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          398..496
                     /region_name="PH_Cool_Pix"
                     /note="Cloned out of library/PAK-interactive exchange
                     factor pleckstrin homology (PH) domain; cd01225"
                     /db_xref="CDD:269932"
     Region          <503..586
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          556..658
                     /region_name="RhoGEF67_u2"
                     /note="Unstructured region two on RhoGEF 6 and 7;
                     pfam16614"
                     /db_xref="CDD:465200"
     Region          728..812
                     /region_name="betaPIX_CC"
                     /note="betaPIX coiled coil; pfam16523"
                     /db_xref="CDD:465158"
     CDS             1..813
                     /gene="ARHGEF7"
                     /gene_synonym="BETA-PIX; COOL-1; COOL1; Nbla10314; P50;
                     P50BP; P85; P85COOL1; P85SPR; PAK3; PIXB"
                     /coded_by="XM_047430725.1:11165..13606"
                     /db_xref="GeneID:8874"
                     /db_xref="HGNC:HGNC:15607"
                     /db_xref="MIM:605477"
ORIGIN      
        1 mtfpkltpcs diaktvmsvi hdktfdandl yqgqnfnkvl sslvtlnkvt adiglgsdsv
       61 carpsshrik sfdslgsqsl htrtsklfqg qyrsldmtdn snnqlvvrak fnfqqtnede
      121 lsfskgdvih vtrveeggww egtlngrtgw fpsnyvrevk asekpvspks gtlksppkgf
      181 dttainksyy nvvlqnilet eneyskelqt vlstylrplq tseklssani sylmgnleei
      241 csfqqmlvqs leectklpea qqrvggcfln lmpqmktlyl tycanhpsav nvltehseel
      301 gefmetkgas spgilvlttg lskpfmrldk yptllkeler hmedyhtdrq diqksmaafk
      361 nlsaqcqevr krkelelqil teairnwegd diktlgnvty msqvliqcag seekneryll
      421 lfpnvllmls asprmsgfiy qgklpttgmt itkledsenh rnafeisgsm ierilvscnn
      481 qqdlqewveh lqkqtkvtsv gnptikphsv pshtlpshpv tpsskhadsk papltpayht
      541 lphpshhgtp httinwgple ppktpkpwsl sclrpapplr psaalcykev rsldhsnsqm
      601 tdlskspktm kkllpkrkpe rkpsdeefas rkstaaleed aqilkvieay ctsaktrqtl
      661 nstwqgtdlm hnhvladddq psldslgrrs slsrlepsdl sedsdydsiw tahsyrmgst
      721 srsrkesapq vllpeeekii veetksngqt vieekslvdt vyalkdevqe lrqdnkkmkk
      781 sleeeqrark dleklvrkvl knmndpawde tnl
//
LOCUS       XP_047286682             802 aa            linear   PRI 05-AUG-2025
DEFINITION  rho guanine nucleotide exchange factor 7 isoform X6 [Homo sapiens].
ACCESSION   XP_047286682
VERSION     XP_047286682.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430726.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..802
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..802
                     /product="rho guanine nucleotide exchange factor 7 isoform
                     X6"
                     /calculated_mol_wt=90489
     Region          3..>89
                     /region_name="CH_SF"
                     /note="calponin homology (CH) domain superfamily; cl00030"
                     /db_xref="CDD:469584"
     Region          95..148
                     /region_name="SH3_betaPIX"
                     /note="Src Homology 3 domain of beta-Pak Interactive
                     eXchange factor; cd12061"
                     /db_xref="CDD:212994"
     Site            order(100,102,105,108..109,124,126..128,139,141,143..144)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212994"
     Region          179..356
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
                     (DH) domain. It appears that PH domains invariably occur
                     C-terminal to RhoGEF/DH domains; cd00160"
                     /db_xref="CDD:238091"
     Site            order(185,189,283,307..308,311..312,314..315,318..319,
                     322..323,326,352,356)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          387..485
                     /region_name="PH_Cool_Pix"
                     /note="Cloned out of library/PAK-interactive exchange
                     factor pleckstrin homology (PH) domain; cd01225"
                     /db_xref="CDD:269932"
     Region          <492..575
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          545..647
                     /region_name="RhoGEF67_u2"
                     /note="Unstructured region two on RhoGEF 6 and 7;
                     pfam16614"
                     /db_xref="CDD:465200"
     Region          717..801
                     /region_name="betaPIX_CC"
                     /note="betaPIX coiled coil; pfam16523"
                     /db_xref="CDD:465158"
     CDS             1..802
                     /gene="ARHGEF7"
                     /gene_synonym="BETA-PIX; COOL-1; COOL1; Nbla10314; P50;
                     P50BP; P85; P85COOL1; P85SPR; PAK3; PIXB"
                     /coded_by="XM_047430726.1:909..3317"
                     /db_xref="GeneID:8874"
                     /db_xref="HGNC:HGNC:15607"
                     /db_xref="MIM:605477"
ORIGIN      
        1 mnsaeqtvtw litlgvlesp kktisdpegf lqaslkdgvv lcrllerllp gtiekvypep
       61 rseseclsni reflrgcgas lrledmtdns nnqlvvrakf nfqqtnedel sfskgdvihv
      121 trveeggwwe gtlngrtgwf psnyvrevka sekpvspksg tlksppkgfd ttainksyyn
      181 vvlqnilete neyskelqtv lstylrplqt seklssanis ylmgnleeic sfqqmlvqsl
      241 eectklpeaq qrvggcflnl mpqmktlylt ycanhpsavn vltehseelg efmetkgass
      301 pgilvlttgl skpfmrldky ptllkelerh medyhtdrqd iqksmaafkn lsaqcqevrk
      361 rkelelqilt eairnwegdd iktlgnvtym sqvliqcags eeknerylll fpnvllmlsa
      421 sprmsgfiyq gklpttgmti tkledsenhr nafeisgsmi erilvscnnq qdlqewvehl
      481 qkqtkvtsvg nptikphsvp shtlpshpvt psskhadskp apltpayhtl phpshhgtph
      541 ttinwgplep pktpkpwsls clrpapplrp saalcykevr sldhsnsqmt dlskspktmk
      601 kllpkrkper kpsdeefasr kstaaleeda qilkvieayc tsaktrqtln stwqgtdlmh
      661 nhvladddqp sldslgrrss lsrlepsdls edsdydsiwt ahsyrmgsts rsrkesapqv
      721 llpeeekiiv eetksngqtv ieekslvdtv yalkdevqel rqdnkkmkks leeeqrarkd
      781 leklvrkvlk nmndpawdet nl
//
LOCUS       XP_047286683             792 aa            linear   PRI 05-AUG-2025
DEFINITION  rho guanine nucleotide exchange factor 7 isoform X7 [Homo sapiens].
ACCESSION   XP_047286683
VERSION     XP_047286683.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430727.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..792
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..792
                     /product="rho guanine nucleotide exchange factor 7 isoform
                     X7"
                     /calculated_mol_wt=89322
     Region          <1..33
                     /region_name="CH_SF"
                     /note="calponin homology (CH) domain superfamily; cl00030"
                     /db_xref="CDD:469584"
     Region          35..81
                     /region_name="RhoGEF67_u1"
                     /note="Unstructured region one on RhoGEF 6 and 7;
                     pfam16615"
                     /db_xref="CDD:465201"
     Region          85..138
                     /region_name="SH3_betaPIX"
                     /note="Src Homology 3 domain of beta-Pak Interactive
                     eXchange factor; cd12061"
                     /db_xref="CDD:212994"
     Site            order(90,92,95,98..99,114,116..118,129,131,133..134)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212994"
     Region          169..346
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
                     (DH) domain. It appears that PH domains invariably occur
                     C-terminal to RhoGEF/DH domains; cd00160"
                     /db_xref="CDD:238091"
     Site            order(175,179,273,297..298,301..302,304..305,308..309,
                     312..313,316,342,346)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          377..475
                     /region_name="PH_Cool_Pix"
                     /note="Cloned out of library/PAK-interactive exchange
                     factor pleckstrin homology (PH) domain; cd01225"
                     /db_xref="CDD:269932"
     Region          <482..565
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          535..637
                     /region_name="RhoGEF67_u2"
                     /note="Unstructured region two on RhoGEF 6 and 7;
                     pfam16614"
                     /db_xref="CDD:465200"
     Region          707..791
                     /region_name="betaPIX_CC"
                     /note="betaPIX coiled coil; pfam16523"
                     /db_xref="CDD:465158"
     CDS             1..792
                     /gene="ARHGEF7"
                     /gene_synonym="BETA-PIX; COOL-1; COOL1; Nbla10314; P50;
                     P50BP; P85; P85COOL1; P85SPR; PAK3; PIXB"
                     /coded_by="XM_047430727.1:53..2431"
                     /db_xref="GeneID:8874"
                     /db_xref="HGNC:HGNC:15607"
                     /db_xref="MIM:605477"
ORIGIN      
        1 mktfdandly qgqnfnkvls slvtlnkvta diglgsdsvc arpsshriks fdslgsqslh
       61 trtsklfqgq yrsldmtdns nnqlvvrakf nfqqtnedel sfskgdvihv trveeggwwe
      121 gtlngrtgwf psnyvrevka sekpvspksg tlksppkgfd ttainksyyn vvlqnilete
      181 neyskelqtv lstylrplqt seklssanis ylmgnleeic sfqqmlvqsl eectklpeaq
      241 qrvggcflnl mpqmktlylt ycanhpsavn vltehseelg efmetkgass pgilvlttgl
      301 skpfmrldky ptllkelerh medyhtdrqd iqksmaafkn lsaqcqevrk rkelelqilt
      361 eairnwegdd iktlgnvtym sqvliqcags eeknerylll fpnvllmlsa sprmsgfiyq
      421 gklpttgmti tkledsenhr nafeisgsmi erilvscnnq qdlqewvehl qkqtkvtsvg
      481 nptikphsvp shtlpshpvt psskhadskp apltpayhtl phpshhgtph ttinwgplep
      541 pktpkpwsls clrpapplrp saalcykevr sldhsnsqmt dlskspktmk kllpkrkper
      601 kpsdeefasr kstaaleeda qilkvieayc tsaktrqtln stwqgtdlmh nhvladddqp
      661 sldslgrrss lsrlepsdls edsdydsiwt ahsyrmgsts rsrkesapqv llpeeekiiv
      721 eetksngqtv ieekslvdtv yalkdevqel rqdnkkmkks leeeqrarkd leklvrkvlk
      781 nmndpawdet nl
//
LOCUS       XP_047286684             790 aa            linear   PRI 05-AUG-2025
DEFINITION  rho guanine nucleotide exchange factor 7 isoform X8 [Homo sapiens].
ACCESSION   XP_047286684
VERSION     XP_047286684.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430728.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..790
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..790
                     /product="rho guanine nucleotide exchange factor 7 isoform
                     X8"
                     /calculated_mol_wt=89133
     Region          3..>89
                     /region_name="CH_SF"
                     /note="calponin homology (CH) domain superfamily; cl00030"
                     /db_xref="CDD:469584"
     Region          95..148
                     /region_name="SH3_betaPIX"
                     /note="Src Homology 3 domain of beta-Pak Interactive
                     eXchange factor; cd12061"
                     /db_xref="CDD:212994"
     Site            order(100,102,105,108..109,124,126..128,139,141,143..144)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212994"
     Region          179..356
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
                     (DH) domain. It appears that PH domains invariably occur
                     C-terminal to RhoGEF/DH domains; cd00160"
                     /db_xref="CDD:238091"
     Site            order(185,189,283,307..308,311..312,314..315,318..319,
                     322..323,326,352,356)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          387..485
                     /region_name="PH_Cool_Pix"
                     /note="Cloned out of library/PAK-interactive exchange
                     factor pleckstrin homology (PH) domain; cd01225"
                     /db_xref="CDD:269932"
     Region          545..635
                     /region_name="RhoGEF67_u2"
                     /note="Unstructured region two on RhoGEF 6 and 7;
                     pfam16614"
                     /db_xref="CDD:465200"
     Region          705..789
                     /region_name="betaPIX_CC"
                     /note="betaPIX coiled coil; pfam16523"
                     /db_xref="CDD:465158"
     CDS             1..790
                     /gene="ARHGEF7"
                     /gene_synonym="BETA-PIX; COOL-1; COOL1; Nbla10314; P50;
                     P50BP; P85; P85COOL1; P85SPR; PAK3; PIXB"
                     /coded_by="XM_047430728.1:909..3281"
                     /db_xref="GeneID:8874"
                     /db_xref="HGNC:HGNC:15607"
                     /db_xref="MIM:605477"
ORIGIN      
        1 mnsaeqtvtw litlgvlesp kktisdpegf lqaslkdgvv lcrllerllp gtiekvypep
       61 rseseclsni reflrgcgas lrledmtdns nnqlvvrakf nfqqtnedel sfskgdvihv
      121 trveeggwwe gtlngrtgwf psnyvrevka sekpvspksg tlksppkgfd ttainksyyn
      181 vvlqnilete neyskelqtv lstylrplqt seklssanis ylmgnleeic sfqqmlvqsl
      241 eectklpeaq qrvggcflnl mpqmktlylt ycanhpsavn vltehseelg efmetkgass
      301 pgilvlttgl skpfmrldky ptllkelerh medyhtdrqd iqksmaafkn lsaqcqevrk
      361 rkelelqilt eairnwegdd iktlgnvtym sqvliqcags eeknerylll fpnvllmlsa
      421 sprmsgfiyq gklpttgmti tkledsenhr nafeisgsmi erilvscnnq qdlqewvehl
      481 qkqtkvtsvg nptikphsvp shtlpshpvt psskhadskp apltpayhtl phpshhgtph
      541 ttinwgplep pktpkpwsls clrpapplrp saalcykedl skspktmkkl lpkrkperkp
      601 sdeefasrks taaleedaqi lkvieaycts aktrqtlnst wqgtdlmhnh vladddqpsl
      661 dslgrrssls rlepsdlsed sdydsiwtah syrmgstsrs rkesapqvll peeekiivee
      721 tksngqtvie ekslvdtvya lkdevqelrq dnkkmkksle eeqrarkdle klvrkvlknm
      781 ndpawdetnl
//
LOCUS       XP_047286685             774 aa            linear   PRI 05-AUG-2025
DEFINITION  rho guanine nucleotide exchange factor 7 isoform X9 [Homo sapiens].
ACCESSION   XP_047286685
VERSION     XP_047286685.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430729.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..774
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..774
                     /product="rho guanine nucleotide exchange factor 7 isoform
                     X9"
                     /calculated_mol_wt=87036
     Region          3..86
                     /region_name="CH_SF"
                     /note="calponin homology (CH) domain superfamily; cl00030"
                     /db_xref="CDD:469584"
     Region          88..134
                     /region_name="RhoGEF67_u1"
                     /note="Unstructured region one on RhoGEF 6 and 7;
                     pfam16615"
                     /db_xref="CDD:465201"
     Region          138..191
                     /region_name="SH3_betaPIX"
                     /note="Src Homology 3 domain of beta-Pak Interactive
                     eXchange factor; cd12061"
                     /db_xref="CDD:212994"
     Site            order(143,145,148,151..152,167,169..171,182,184,186..187)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212994"
     Region          222..399
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
                     (DH) domain. It appears that PH domains invariably occur
                     C-terminal to RhoGEF/DH domains; cd00160"
                     /db_xref="CDD:238091"
     Site            order(228,232,326,350..351,354..355,357..358,361..362,
                     365..366,369,395,399)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          430..528
                     /region_name="PH_Cool_Pix"
                     /note="Cloned out of library/PAK-interactive exchange
                     factor pleckstrin homology (PH) domain; cd01225"
                     /db_xref="CDD:269932"
     Region          588..678
                     /region_name="RhoGEF67_u2"
                     /note="Unstructured region two on RhoGEF 6 and 7;
                     pfam16614"
                     /db_xref="CDD:465200"
     Region          689..773
                     /region_name="betaPIX_CC"
                     /note="betaPIX coiled coil; pfam16523"
                     /db_xref="CDD:465158"
     CDS             1..774
                     /gene="ARHGEF7"
                     /gene_synonym="BETA-PIX; COOL-1; COOL1; Nbla10314; P50;
                     P50BP; P85; P85COOL1; P85SPR; PAK3; PIXB"
                     /coded_by="XM_047430729.1:909..3233"
                     /db_xref="GeneID:8874"
                     /db_xref="HGNC:HGNC:15607"
                     /db_xref="MIM:605477"
ORIGIN      
        1 mnsaeqtvtw litlgvlesp kktisdpegf lqaslkdgvv lcrllerllp gtiektfdan
       61 dlyqgqnfnk vlsslvtlnk vtadiglgsd svcarpsshr iksfdslgsq slhtrtsklf
      121 qgqyrsldmt dnsnnqlvvr akfnfqqtne delsfskgdv ihvtrveegg wwegtlngrt
      181 gwfpsnyvre vkasekpvsp ksgtlksppk gfdttainks yynvvlqnil eteneyskel
      241 qtvlstylrp lqtseklssa nisylmgnle eicsfqqmlv qsleectklp eaqqrvggcf
      301 lnlmpqmktl yltycanhps avnvltehse elgefmetkg asspgilvlt tglskpfmrl
      361 dkyptllkel erhmedyhtd rqdiqksmaa fknlsaqcqe vrkrkelelq ilteairnwe
      421 gddiktlgnv tymsqvliqc agseeknery lllfpnvllm lsasprmsgf iyqgklpttg
      481 mtitkledse nhrnafeisg smierilvsc nnqqdlqewv ehlqkqtkvt svgnptikph
      541 svpshtlpsh pvtpsskhad skpapltpay htlphpshhg tphttinwgp leppktpkpw
      601 slsclrpapp lrpsaalcyk edlskspktm kkllpkrkpe rkpsdeefas rkstaaleed
      661 aqilkvieay ctsaktrqtl nsssrkesap qvllpeeeki iveetksngq tvieekslvd
      721 tvyalkdevq elrqdnkkmk ksleeeqrar kdleklvrkv lknmndpawd etnl
//
LOCUS       XP_016876304             743 aa            linear   PRI 05-AUG-2025
DEFINITION  rho guanine nucleotide exchange factor 7 isoform X10 [Homo
            sapiens].
ACCESSION   XP_016876304
VERSION     XP_016876304.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020815.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..743
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..743
                     /product="rho guanine nucleotide exchange factor 7 isoform
                     X10"
                     /calculated_mol_wt=83797
     Region          3..>89
                     /region_name="CH_SF"
                     /note="calponin homology (CH) domain superfamily; cl00030"
                     /db_xref="CDD:469584"
     Region          95..148
                     /region_name="SH3_betaPIX"
                     /note="Src Homology 3 domain of beta-Pak Interactive
                     eXchange factor; cd12061"
                     /db_xref="CDD:212994"
     Site            order(100,102,105,108..109,124,126..128,139,141,143..144)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212994"
     Region          179..356
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
                     (DH) domain. It appears that PH domains invariably occur
                     C-terminal to RhoGEF/DH domains; cd00160"
                     /db_xref="CDD:238091"
     Site            order(185,189,283,307..308,311..312,314..315,318..319,
                     322..323,326,352,356)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          387..485
                     /region_name="PH_Cool_Pix"
                     /note="Cloned out of library/PAK-interactive exchange
                     factor pleckstrin homology (PH) domain; cd01225"
                     /db_xref="CDD:269932"
     Region          <492..575
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          545..647
                     /region_name="RhoGEF67_u2"
                     /note="Unstructured region two on RhoGEF 6 and 7;
                     pfam16614"
                     /db_xref="CDD:465200"
     Region          658..742
                     /region_name="betaPIX_CC"
                     /note="betaPIX coiled coil; pfam16523"
                     /db_xref="CDD:465158"
     CDS             1..743
                     /gene="ARHGEF7"
                     /gene_synonym="BETA-PIX; COOL-1; COOL1; Nbla10314; P50;
                     P50BP; P85; P85COOL1; P85SPR; PAK3; PIXB"
                     /coded_by="XM_017020815.2:909..3140"
                     /db_xref="GeneID:8874"
                     /db_xref="HGNC:HGNC:15607"
                     /db_xref="MIM:605477"
ORIGIN      
        1 mnsaeqtvtw litlgvlesp kktisdpegf lqaslkdgvv lcrllerllp gtiekvypep
       61 rseseclsni reflrgcgas lrledmtdns nnqlvvrakf nfqqtnedel sfskgdvihv
      121 trveeggwwe gtlngrtgwf psnyvrevka sekpvspksg tlksppkgfd ttainksyyn
      181 vvlqnilete neyskelqtv lstylrplqt seklssanis ylmgnleeic sfqqmlvqsl
      241 eectklpeaq qrvggcflnl mpqmktlylt ycanhpsavn vltehseelg efmetkgass
      301 pgilvlttgl skpfmrldky ptllkelerh medyhtdrqd iqksmaafkn lsaqcqevrk
      361 rkelelqilt eairnwegdd iktlgnvtym sqvliqcags eeknerylll fpnvllmlsa
      421 sprmsgfiyq gklpttgmti tkledsenhr nafeisgsmi erilvscnnq qdlqewvehl
      481 qkqtkvtsvg nptikphsvp shtlpshpvt psskhadskp apltpayhtl phpshhgtph
      541 ttinwgplep pktpkpwsls clrpapplrp saalcykevr sldhsnsqmt dlskspktmk
      601 kllpkrkper kpsdeefasr kstaaleeda qilkvieayc tsaktrqtln sssrkesapq
      661 vllpeeekii veetksngqt vieekslvdt vyalkdevqe lrqdnkkmkk sleeeqrark
      721 dleklvrkvl knmndpawde tnl
//
LOCUS       XP_047286686             742 aa            linear   PRI 05-AUG-2025
DEFINITION  rho guanine nucleotide exchange factor 7 isoform X11 [Homo
            sapiens].
ACCESSION   XP_047286686
VERSION     XP_047286686.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430730.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..742
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..742
                     /product="rho guanine nucleotide exchange factor 7 isoform
                     X11"
                     /calculated_mol_wt=83559
     Region          <18..54
                     /region_name="CH_SF"
                     /note="calponin homology (CH) domain superfamily; cl00030"
                     /db_xref="CDD:469584"
     Region          56..102
                     /region_name="RhoGEF67_u1"
                     /note="Unstructured region one on RhoGEF 6 and 7;
                     pfam16615"
                     /db_xref="CDD:465201"
     Region          106..159
                     /region_name="SH3_betaPIX"
                     /note="Src Homology 3 domain of beta-Pak Interactive
                     eXchange factor; cd12061"
                     /db_xref="CDD:212994"
     Site            order(111,113,116,119..120,135,137..139,150,152,154..155)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212994"
     Region          190..367
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
                     (DH) domain. It appears that PH domains invariably occur
                     C-terminal to RhoGEF/DH domains; cd00160"
                     /db_xref="CDD:238091"
     Site            order(196,200,294,318..319,322..323,325..326,329..330,
                     333..334,337,363,367)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          398..496
                     /region_name="PH_Cool_Pix"
                     /note="Cloned out of library/PAK-interactive exchange
                     factor pleckstrin homology (PH) domain; cd01225"
                     /db_xref="CDD:269932"
     Region          556..646
                     /region_name="RhoGEF67_u2"
                     /note="Unstructured region two on RhoGEF 6 and 7;
                     pfam16614"
                     /db_xref="CDD:465200"
     Region          657..741
                     /region_name="betaPIX_CC"
                     /note="betaPIX coiled coil; pfam16523"
                     /db_xref="CDD:465158"
     CDS             1..742
                     /gene="ARHGEF7"
                     /gene_synonym="BETA-PIX; COOL-1; COOL1; Nbla10314; P50;
                     P50BP; P85; P85COOL1; P85SPR; PAK3; PIXB"
                     /coded_by="XM_047430730.1:11165..13393"
                     /db_xref="GeneID:8874"
                     /db_xref="HGNC:HGNC:15607"
                     /db_xref="MIM:605477"
ORIGIN      
        1 mtfpkltpcs diaktvmsvi hdktfdandl yqgqnfnkvl sslvtlnkvt adiglgsdsv
       61 carpsshrik sfdslgsqsl htrtsklfqg qyrsldmtdn snnqlvvrak fnfqqtnede
      121 lsfskgdvih vtrveeggww egtlngrtgw fpsnyvrevk asekpvspks gtlksppkgf
      181 dttainksyy nvvlqnilet eneyskelqt vlstylrplq tseklssani sylmgnleei
      241 csfqqmlvqs leectklpea qqrvggcfln lmpqmktlyl tycanhpsav nvltehseel
      301 gefmetkgas spgilvlttg lskpfmrldk yptllkeler hmedyhtdrq diqksmaafk
      361 nlsaqcqevr krkelelqil teairnwegd diktlgnvty msqvliqcag seekneryll
      421 lfpnvllmls asprmsgfiy qgklpttgmt itkledsenh rnafeisgsm ierilvscnn
      481 qqdlqewveh lqkqtkvtsv gnptikphsv pshtlpshpv tpsskhadsk papltpayht
      541 lphpshhgtp httinwgple ppktpkpwsl sclrpapplr psaalcyked lskspktmkk
      601 llpkrkperk psdeefasrk staaleedaq ilkvieayct saktrqtlns ssrkesapqv
      661 llpeeekiiv eetksngqtv ieekslvdtv yalkdevqel rqdnkkmkks leeeqrarkd
      721 leklvrkvlk nmndpawdet nl
//
LOCUS       XP_047286688             731 aa            linear   PRI 05-AUG-2025
DEFINITION  rho guanine nucleotide exchange factor 7 isoform X12 [Homo
            sapiens].
ACCESSION   XP_047286688
VERSION     XP_047286688.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430732.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..731
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..731
                     /product="rho guanine nucleotide exchange factor 7 isoform
                     X12"
                     /calculated_mol_wt=82440
     Region          3..>89
                     /region_name="CH_SF"
                     /note="calponin homology (CH) domain superfamily; cl00030"
                     /db_xref="CDD:469584"
     Region          95..148
                     /region_name="SH3_betaPIX"
                     /note="Src Homology 3 domain of beta-Pak Interactive
                     eXchange factor; cd12061"
                     /db_xref="CDD:212994"
     Site            order(100,102,105,108..109,124,126..128,139,141,143..144)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212994"
     Region          179..356
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
                     (DH) domain. It appears that PH domains invariably occur
                     C-terminal to RhoGEF/DH domains; cd00160"
                     /db_xref="CDD:238091"
     Site            order(185,189,283,307..308,311..312,314..315,318..319,
                     322..323,326,352,356)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          387..485
                     /region_name="PH_Cool_Pix"
                     /note="Cloned out of library/PAK-interactive exchange
                     factor pleckstrin homology (PH) domain; cd01225"
                     /db_xref="CDD:269932"
     Region          545..635
                     /region_name="RhoGEF67_u2"
                     /note="Unstructured region two on RhoGEF 6 and 7;
                     pfam16614"
                     /db_xref="CDD:465200"
     Region          646..730
                     /region_name="betaPIX_CC"
                     /note="betaPIX coiled coil; pfam16523"
                     /db_xref="CDD:465158"
     CDS             1..731
                     /gene="ARHGEF7"
                     /gene_synonym="BETA-PIX; COOL-1; COOL1; Nbla10314; P50;
                     P50BP; P85; P85COOL1; P85SPR; PAK3; PIXB"
                     /coded_by="XM_047430732.1:909..3104"
                     /db_xref="GeneID:8874"
                     /db_xref="HGNC:HGNC:15607"
                     /db_xref="MIM:605477"
ORIGIN      
        1 mnsaeqtvtw litlgvlesp kktisdpegf lqaslkdgvv lcrllerllp gtiekvypep
       61 rseseclsni reflrgcgas lrledmtdns nnqlvvrakf nfqqtnedel sfskgdvihv
      121 trveeggwwe gtlngrtgwf psnyvrevka sekpvspksg tlksppkgfd ttainksyyn
      181 vvlqnilete neyskelqtv lstylrplqt seklssanis ylmgnleeic sfqqmlvqsl
      241 eectklpeaq qrvggcflnl mpqmktlylt ycanhpsavn vltehseelg efmetkgass
      301 pgilvlttgl skpfmrldky ptllkelerh medyhtdrqd iqksmaafkn lsaqcqevrk
      361 rkelelqilt eairnwegdd iktlgnvtym sqvliqcags eeknerylll fpnvllmlsa
      421 sprmsgfiyq gklpttgmti tkledsenhr nafeisgsmi erilvscnnq qdlqewvehl
      481 qkqtkvtsvg nptikphsvp shtlpshpvt psskhadskp apltpayhtl phpshhgtph
      541 ttinwgplep pktpkpwsls clrpapplrp saalcykedl skspktmkkl lpkrkperkp
      601 sdeefasrks taaleedaqi lkvieaycts aktrqtlnss srkesapqvl lpeeekiive
      661 etksngqtvi eekslvdtvy alkdevqelr qdnkkmkksl eeeqrarkdl eklvrkvlkn
      721 mndpawdetn l
//
LOCUS       XP_047286689             717 aa            linear   PRI 05-AUG-2025
DEFINITION  rho guanine nucleotide exchange factor 7 isoform X13 [Homo
            sapiens].
ACCESSION   XP_047286689
VERSION     XP_047286689.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430733.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..717
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..717
                     /product="rho guanine nucleotide exchange factor 7 isoform
                     X13"
                     /calculated_mol_wt=81058
     Region          10..63
                     /region_name="SH3_betaPIX"
                     /note="Src Homology 3 domain of beta-Pak Interactive
                     eXchange factor; cd12061"
                     /db_xref="CDD:212994"
     Site            order(15,17,20,23..24,39,41..43,54,56,58..59)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212994"
     Region          94..271
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
                     (DH) domain. It appears that PH domains invariably occur
                     C-terminal to RhoGEF/DH domains; cd00160"
                     /db_xref="CDD:238091"
     Site            order(100,104,198,222..223,226..227,229..230,233..234,
                     237..238,241,267,271)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          302..400
                     /region_name="PH_Cool_Pix"
                     /note="Cloned out of library/PAK-interactive exchange
                     factor pleckstrin homology (PH) domain; cd01225"
                     /db_xref="CDD:269932"
     Region          <407..490
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          460..562
                     /region_name="RhoGEF67_u2"
                     /note="Unstructured region two on RhoGEF 6 and 7;
                     pfam16614"
                     /db_xref="CDD:465200"
     Region          632..716
                     /region_name="betaPIX_CC"
                     /note="betaPIX coiled coil; pfam16523"
                     /db_xref="CDD:465158"
     CDS             1..717
                     /gene="ARHGEF7"
                     /gene_synonym="BETA-PIX; COOL-1; COOL1; Nbla10314; P50;
                     P50BP; P85; P85COOL1; P85SPR; PAK3; PIXB"
                     /coded_by="XM_047430733.1:363..2516"
                     /db_xref="GeneID:8874"
                     /db_xref="HGNC:HGNC:15607"
                     /db_xref="MIM:605477"
ORIGIN      
        1 mtdnsnnqlv vrakfnfqqt nedelsfskg dvihvtrvee ggwwegtlng rtgwfpsnyv
       61 revkasekpv spksgtlksp pkgfdttain ksyynvvlqn ileteneysk elqtvlstyl
      121 rplqtsekls sanisylmgn leeicsfqqm lvqsleectk lpeaqqrvgg cflnlmpqmk
      181 tlyltycanh psavnvlteh seelgefmet kgasspgilv lttglskpfm rldkyptllk
      241 elerhmedyh tdrqdiqksm aafknlsaqc qevrkrkele lqilteairn wegddiktlg
      301 nvtymsqvli qcagseekne rylllfpnvl lmlsasprms gfiyqgklpt tgmtitkled
      361 senhrnafei sgsmierilv scnnqqdlqe wvehlqkqtk vtsvgnptik phsvpshtlp
      421 shpvtpsskh adskpapltp ayhtlphpsh hgtphttinw gpleppktpk pwslsclrpa
      481 pplrpsaalc ykevrsldhs nsqmtdlsks pktmkkllpk rkperkpsde efasrkstaa
      541 leedaqilkv ieayctsakt rqtlnstwqg tdlmhnhvla dddqpsldsl grrsslsrle
      601 psdlsedsdy dsiwtahsyr mgstsrsrke sapqvllpee ekiiveetks ngqtvieeks
      661 lvdtvyalkd evqelrqdnk kmkksleeeq rarkdleklv rkvlknmndp awdetnl
//
LOCUS       XP_047286690             717 aa            linear   PRI 05-AUG-2025
DEFINITION  rho guanine nucleotide exchange factor 7 isoform X13 [Homo
            sapiens].
ACCESSION   XP_047286690
VERSION     XP_047286690.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430734.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..717
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..717
                     /product="rho guanine nucleotide exchange factor 7 isoform
                     X13"
                     /calculated_mol_wt=81058
     Region          10..63
                     /region_name="SH3_betaPIX"
                     /note="Src Homology 3 domain of beta-Pak Interactive
                     eXchange factor; cd12061"
                     /db_xref="CDD:212994"
     Site            order(15,17,20,23..24,39,41..43,54,56,58..59)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212994"
     Region          94..271
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
                     (DH) domain. It appears that PH domains invariably occur
                     C-terminal to RhoGEF/DH domains; cd00160"
                     /db_xref="CDD:238091"
     Site            order(100,104,198,222..223,226..227,229..230,233..234,
                     237..238,241,267,271)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          302..400
                     /region_name="PH_Cool_Pix"
                     /note="Cloned out of library/PAK-interactive exchange
                     factor pleckstrin homology (PH) domain; cd01225"
                     /db_xref="CDD:269932"
     Region          <407..490
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          460..562
                     /region_name="RhoGEF67_u2"
                     /note="Unstructured region two on RhoGEF 6 and 7;
                     pfam16614"
                     /db_xref="CDD:465200"
     Region          632..716
                     /region_name="betaPIX_CC"
                     /note="betaPIX coiled coil; pfam16523"
                     /db_xref="CDD:465158"
     CDS             1..717
                     /gene="ARHGEF7"
                     /gene_synonym="BETA-PIX; COOL-1; COOL1; Nbla10314; P50;
                     P50BP; P85; P85COOL1; P85SPR; PAK3; PIXB"
                     /coded_by="XM_047430734.1:417..2570"
                     /db_xref="GeneID:8874"
                     /db_xref="HGNC:HGNC:15607"
                     /db_xref="MIM:605477"
ORIGIN      
        1 mtdnsnnqlv vrakfnfqqt nedelsfskg dvihvtrvee ggwwegtlng rtgwfpsnyv
       61 revkasekpv spksgtlksp pkgfdttain ksyynvvlqn ileteneysk elqtvlstyl
      121 rplqtsekls sanisylmgn leeicsfqqm lvqsleectk lpeaqqrvgg cflnlmpqmk
      181 tlyltycanh psavnvlteh seelgefmet kgasspgilv lttglskpfm rldkyptllk
      241 elerhmedyh tdrqdiqksm aafknlsaqc qevrkrkele lqilteairn wegddiktlg
      301 nvtymsqvli qcagseekne rylllfpnvl lmlsasprms gfiyqgklpt tgmtitkled
      361 senhrnafei sgsmierilv scnnqqdlqe wvehlqkqtk vtsvgnptik phsvpshtlp
      421 shpvtpsskh adskpapltp ayhtlphpsh hgtphttinw gpleppktpk pwslsclrpa
      481 pplrpsaalc ykevrsldhs nsqmtdlsks pktmkkllpk rkperkpsde efasrkstaa
      541 leedaqilkv ieayctsakt rqtlnstwqg tdlmhnhvla dddqpsldsl grrsslsrle
      601 psdlsedsdy dsiwtahsyr mgstsrsrke sapqvllpee ekiiveetks ngqtvieeks
      661 lvdtvyalkd evqelrqdnk kmkksleeeq rarkdleklv rkvlknmndp awdetnl
//
LOCUS       XP_047286691             717 aa            linear   PRI 05-AUG-2025
DEFINITION  rho guanine nucleotide exchange factor 7 isoform X13 [Homo
            sapiens].
ACCESSION   XP_047286691
VERSION     XP_047286691.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430735.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..717
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..717
                     /product="rho guanine nucleotide exchange factor 7 isoform
                     X13"
                     /calculated_mol_wt=81058
     Region          10..63
                     /region_name="SH3_betaPIX"
                     /note="Src Homology 3 domain of beta-Pak Interactive
                     eXchange factor; cd12061"
                     /db_xref="CDD:212994"
     Site            order(15,17,20,23..24,39,41..43,54,56,58..59)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212994"
     Region          94..271
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
                     (DH) domain. It appears that PH domains invariably occur
                     C-terminal to RhoGEF/DH domains; cd00160"
                     /db_xref="CDD:238091"
     Site            order(100,104,198,222..223,226..227,229..230,233..234,
                     237..238,241,267,271)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          302..400
                     /region_name="PH_Cool_Pix"
                     /note="Cloned out of library/PAK-interactive exchange
                     factor pleckstrin homology (PH) domain; cd01225"
                     /db_xref="CDD:269932"
     Region          <407..490
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          460..562
                     /region_name="RhoGEF67_u2"
                     /note="Unstructured region two on RhoGEF 6 and 7;
                     pfam16614"
                     /db_xref="CDD:465200"
     Region          632..716
                     /region_name="betaPIX_CC"
                     /note="betaPIX coiled coil; pfam16523"
                     /db_xref="CDD:465158"
     CDS             1..717
                     /gene="ARHGEF7"
                     /gene_synonym="BETA-PIX; COOL-1; COOL1; Nbla10314; P50;
                     P50BP; P85; P85COOL1; P85SPR; PAK3; PIXB"
                     /coded_by="XM_047430735.1:278..2431"
                     /db_xref="GeneID:8874"
                     /db_xref="HGNC:HGNC:15607"
                     /db_xref="MIM:605477"
ORIGIN      
        1 mtdnsnnqlv vrakfnfqqt nedelsfskg dvihvtrvee ggwwegtlng rtgwfpsnyv
       61 revkasekpv spksgtlksp pkgfdttain ksyynvvlqn ileteneysk elqtvlstyl
      121 rplqtsekls sanisylmgn leeicsfqqm lvqsleectk lpeaqqrvgg cflnlmpqmk
      181 tlyltycanh psavnvlteh seelgefmet kgasspgilv lttglskpfm rldkyptllk
      241 elerhmedyh tdrqdiqksm aafknlsaqc qevrkrkele lqilteairn wegddiktlg
      301 nvtymsqvli qcagseekne rylllfpnvl lmlsasprms gfiyqgklpt tgmtitkled
      361 senhrnafei sgsmierilv scnnqqdlqe wvehlqkqtk vtsvgnptik phsvpshtlp
      421 shpvtpsskh adskpapltp ayhtlphpsh hgtphttinw gpleppktpk pwslsclrpa
      481 pplrpsaalc ykevrsldhs nsqmtdlsks pktmkkllpk rkperkpsde efasrkstaa
      541 leedaqilkv ieayctsakt rqtlnstwqg tdlmhnhvla dddqpsldsl grrsslsrle
      601 psdlsedsdy dsiwtahsyr mgstsrsrke sapqvllpee ekiiveetks ngqtvieeks
      661 lvdtvyalkd evqelrqdnk kmkksleeeq rarkdleklv rkvlknmndp awdetnl
//
LOCUS       XP_047286692             717 aa            linear   PRI 05-AUG-2025
DEFINITION  rho guanine nucleotide exchange factor 7 isoform X13 [Homo
            sapiens].
ACCESSION   XP_047286692
VERSION     XP_047286692.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430736.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..717
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..717
                     /product="rho guanine nucleotide exchange factor 7 isoform
                     X13"
                     /calculated_mol_wt=81058
     Region          10..63
                     /region_name="SH3_betaPIX"
                     /note="Src Homology 3 domain of beta-Pak Interactive
                     eXchange factor; cd12061"
                     /db_xref="CDD:212994"
     Site            order(15,17,20,23..24,39,41..43,54,56,58..59)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212994"
     Region          94..271
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
                     (DH) domain. It appears that PH domains invariably occur
                     C-terminal to RhoGEF/DH domains; cd00160"
                     /db_xref="CDD:238091"
     Site            order(100,104,198,222..223,226..227,229..230,233..234,
                     237..238,241,267,271)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          302..400
                     /region_name="PH_Cool_Pix"
                     /note="Cloned out of library/PAK-interactive exchange
                     factor pleckstrin homology (PH) domain; cd01225"
                     /db_xref="CDD:269932"
     Region          <407..490
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          460..562
                     /region_name="RhoGEF67_u2"
                     /note="Unstructured region two on RhoGEF 6 and 7;
                     pfam16614"
                     /db_xref="CDD:465200"
     Region          632..716
                     /region_name="betaPIX_CC"
                     /note="betaPIX coiled coil; pfam16523"
                     /db_xref="CDD:465158"
     CDS             1..717
                     /gene="ARHGEF7"
                     /gene_synonym="BETA-PIX; COOL-1; COOL1; Nbla10314; P50;
                     P50BP; P85; P85COOL1; P85SPR; PAK3; PIXB"
                     /coded_by="XM_047430736.1:147..2300"
                     /db_xref="GeneID:8874"
                     /db_xref="HGNC:HGNC:15607"
                     /db_xref="MIM:605477"
ORIGIN      
        1 mtdnsnnqlv vrakfnfqqt nedelsfskg dvihvtrvee ggwwegtlng rtgwfpsnyv
       61 revkasekpv spksgtlksp pkgfdttain ksyynvvlqn ileteneysk elqtvlstyl
      121 rplqtsekls sanisylmgn leeicsfqqm lvqsleectk lpeaqqrvgg cflnlmpqmk
      181 tlyltycanh psavnvlteh seelgefmet kgasspgilv lttglskpfm rldkyptllk
      241 elerhmedyh tdrqdiqksm aafknlsaqc qevrkrkele lqilteairn wegddiktlg
      301 nvtymsqvli qcagseekne rylllfpnvl lmlsasprms gfiyqgklpt tgmtitkled
      361 senhrnafei sgsmierilv scnnqqdlqe wvehlqkqtk vtsvgnptik phsvpshtlp
      421 shpvtpsskh adskpapltp ayhtlphpsh hgtphttinw gpleppktpk pwslsclrpa
      481 pplrpsaalc ykevrsldhs nsqmtdlsks pktmkkllpk rkperkpsde efasrkstaa
      541 leedaqilkv ieayctsakt rqtlnstwqg tdlmhnhvla dddqpsldsl grrsslsrle
      601 psdlsedsdy dsiwtahsyr mgstsrsrke sapqvllpee ekiiveetks ngqtvieeks
      661 lvdtvyalkd evqelrqdnk kmkksleeeq rarkdleklv rkvlknmndp awdetnl
//
LOCUS       XP_047286693             717 aa            linear   PRI 05-AUG-2025
DEFINITION  rho guanine nucleotide exchange factor 7 isoform X13 [Homo
            sapiens].
ACCESSION   XP_047286693
VERSION     XP_047286693.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430737.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..717
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..717
                     /product="rho guanine nucleotide exchange factor 7 isoform
                     X13"
                     /calculated_mol_wt=81058
     Region          10..63
                     /region_name="SH3_betaPIX"
                     /note="Src Homology 3 domain of beta-Pak Interactive
                     eXchange factor; cd12061"
                     /db_xref="CDD:212994"
     Site            order(15,17,20,23..24,39,41..43,54,56,58..59)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212994"
     Region          94..271
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
                     (DH) domain. It appears that PH domains invariably occur
                     C-terminal to RhoGEF/DH domains; cd00160"
                     /db_xref="CDD:238091"
     Site            order(100,104,198,222..223,226..227,229..230,233..234,
                     237..238,241,267,271)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          302..400
                     /region_name="PH_Cool_Pix"
                     /note="Cloned out of library/PAK-interactive exchange
                     factor pleckstrin homology (PH) domain; cd01225"
                     /db_xref="CDD:269932"
     Region          <407..490
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          460..562
                     /region_name="RhoGEF67_u2"
                     /note="Unstructured region two on RhoGEF 6 and 7;
                     pfam16614"
                     /db_xref="CDD:465200"
     Region          632..716
                     /region_name="betaPIX_CC"
                     /note="betaPIX coiled coil; pfam16523"
                     /db_xref="CDD:465158"
     CDS             1..717
                     /gene="ARHGEF7"
                     /gene_synonym="BETA-PIX; COOL-1; COOL1; Nbla10314; P50;
                     P50BP; P85; P85COOL1; P85SPR; PAK3; PIXB"
                     /coded_by="XM_047430737.1:268..2421"
                     /db_xref="GeneID:8874"
                     /db_xref="HGNC:HGNC:15607"
                     /db_xref="MIM:605477"
ORIGIN      
        1 mtdnsnnqlv vrakfnfqqt nedelsfskg dvihvtrvee ggwwegtlng rtgwfpsnyv
       61 revkasekpv spksgtlksp pkgfdttain ksyynvvlqn ileteneysk elqtvlstyl
      121 rplqtsekls sanisylmgn leeicsfqqm lvqsleectk lpeaqqrvgg cflnlmpqmk
      181 tlyltycanh psavnvlteh seelgefmet kgasspgilv lttglskpfm rldkyptllk
      241 elerhmedyh tdrqdiqksm aafknlsaqc qevrkrkele lqilteairn wegddiktlg
      301 nvtymsqvli qcagseekne rylllfpnvl lmlsasprms gfiyqgklpt tgmtitkled
      361 senhrnafei sgsmierilv scnnqqdlqe wvehlqkqtk vtsvgnptik phsvpshtlp
      421 shpvtpsskh adskpapltp ayhtlphpsh hgtphttinw gpleppktpk pwslsclrpa
      481 pplrpsaalc ykevrsldhs nsqmtdlsks pktmkkllpk rkperkpsde efasrkstaa
      541 leedaqilkv ieayctsakt rqtlnstwqg tdlmhnhvla dddqpsldsl grrsslsrle
      601 psdlsedsdy dsiwtahsyr mgstsrsrke sapqvllpee ekiiveetks ngqtvieeks
      661 lvdtvyalkd evqelrqdnk kmkksleeeq rarkdleklv rkvlknmndp awdetnl
//
LOCUS       XP_047286694             717 aa            linear   PRI 05-AUG-2025
DEFINITION  rho guanine nucleotide exchange factor 7 isoform X13 [Homo
            sapiens].
ACCESSION   XP_047286694
VERSION     XP_047286694.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430738.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..717
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..717
                     /product="rho guanine nucleotide exchange factor 7 isoform
                     X13"
                     /calculated_mol_wt=81058
     Region          10..63
                     /region_name="SH3_betaPIX"
                     /note="Src Homology 3 domain of beta-Pak Interactive
                     eXchange factor; cd12061"
                     /db_xref="CDD:212994"
     Site            order(15,17,20,23..24,39,41..43,54,56,58..59)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212994"
     Region          94..271
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
                     (DH) domain. It appears that PH domains invariably occur
                     C-terminal to RhoGEF/DH domains; cd00160"
                     /db_xref="CDD:238091"
     Site            order(100,104,198,222..223,226..227,229..230,233..234,
                     237..238,241,267,271)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          302..400
                     /region_name="PH_Cool_Pix"
                     /note="Cloned out of library/PAK-interactive exchange
                     factor pleckstrin homology (PH) domain; cd01225"
                     /db_xref="CDD:269932"
     Region          <407..490
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          460..562
                     /region_name="RhoGEF67_u2"
                     /note="Unstructured region two on RhoGEF 6 and 7;
                     pfam16614"
                     /db_xref="CDD:465200"
     Region          632..716
                     /region_name="betaPIX_CC"
                     /note="betaPIX coiled coil; pfam16523"
                     /db_xref="CDD:465158"
     CDS             1..717
                     /gene="ARHGEF7"
                     /gene_synonym="BETA-PIX; COOL-1; COOL1; Nbla10314; P50;
                     P50BP; P85; P85COOL1; P85SPR; PAK3; PIXB"
                     /coded_by="XM_047430738.1:388..2541"
                     /db_xref="GeneID:8874"
                     /db_xref="HGNC:HGNC:15607"
                     /db_xref="MIM:605477"
ORIGIN      
        1 mtdnsnnqlv vrakfnfqqt nedelsfskg dvihvtrvee ggwwegtlng rtgwfpsnyv
       61 revkasekpv spksgtlksp pkgfdttain ksyynvvlqn ileteneysk elqtvlstyl
      121 rplqtsekls sanisylmgn leeicsfqqm lvqsleectk lpeaqqrvgg cflnlmpqmk
      181 tlyltycanh psavnvlteh seelgefmet kgasspgilv lttglskpfm rldkyptllk
      241 elerhmedyh tdrqdiqksm aafknlsaqc qevrkrkele lqilteairn wegddiktlg
      301 nvtymsqvli qcagseekne rylllfpnvl lmlsasprms gfiyqgklpt tgmtitkled
      361 senhrnafei sgsmierilv scnnqqdlqe wvehlqkqtk vtsvgnptik phsvpshtlp
      421 shpvtpsskh adskpapltp ayhtlphpsh hgtphttinw gpleppktpk pwslsclrpa
      481 pplrpsaalc ykevrsldhs nsqmtdlsks pktmkkllpk rkperkpsde efasrkstaa
      541 leedaqilkv ieayctsakt rqtlnstwqg tdlmhnhvla dddqpsldsl grrsslsrle
      601 psdlsedsdy dsiwtahsyr mgstsrsrke sapqvllpee ekiiveetks ngqtvieeks
      661 lvdtvyalkd evqelrqdnk kmkksleeeq rarkdleklv rkvlknmndp awdetnl
//
LOCUS       XP_047286695             717 aa            linear   PRI 05-AUG-2025
DEFINITION  rho guanine nucleotide exchange factor 7 isoform X13 [Homo
            sapiens].
ACCESSION   XP_047286695
VERSION     XP_047286695.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430739.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..717
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..717
                     /product="rho guanine nucleotide exchange factor 7 isoform
                     X13"
                     /calculated_mol_wt=81058
     Region          10..63
                     /region_name="SH3_betaPIX"
                     /note="Src Homology 3 domain of beta-Pak Interactive
                     eXchange factor; cd12061"
                     /db_xref="CDD:212994"
     Site            order(15,17,20,23..24,39,41..43,54,56,58..59)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212994"
     Region          94..271
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
                     (DH) domain. It appears that PH domains invariably occur
                     C-terminal to RhoGEF/DH domains; cd00160"
                     /db_xref="CDD:238091"
     Site            order(100,104,198,222..223,226..227,229..230,233..234,
                     237..238,241,267,271)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          302..400
                     /region_name="PH_Cool_Pix"
                     /note="Cloned out of library/PAK-interactive exchange
                     factor pleckstrin homology (PH) domain; cd01225"
                     /db_xref="CDD:269932"
     Region          <407..490
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          460..562
                     /region_name="RhoGEF67_u2"
                     /note="Unstructured region two on RhoGEF 6 and 7;
                     pfam16614"
                     /db_xref="CDD:465200"
     Region          632..716
                     /region_name="betaPIX_CC"
                     /note="betaPIX coiled coil; pfam16523"
                     /db_xref="CDD:465158"
     CDS             1..717
                     /gene="ARHGEF7"
                     /gene_synonym="BETA-PIX; COOL-1; COOL1; Nbla10314; P50;
                     P50BP; P85; P85COOL1; P85SPR; PAK3; PIXB"
                     /coded_by="XM_047430739.1:1269..3422"
                     /db_xref="GeneID:8874"
                     /db_xref="HGNC:HGNC:15607"
                     /db_xref="MIM:605477"
ORIGIN      
        1 mtdnsnnqlv vrakfnfqqt nedelsfskg dvihvtrvee ggwwegtlng rtgwfpsnyv
       61 revkasekpv spksgtlksp pkgfdttain ksyynvvlqn ileteneysk elqtvlstyl
      121 rplqtsekls sanisylmgn leeicsfqqm lvqsleectk lpeaqqrvgg cflnlmpqmk
      181 tlyltycanh psavnvlteh seelgefmet kgasspgilv lttglskpfm rldkyptllk
      241 elerhmedyh tdrqdiqksm aafknlsaqc qevrkrkele lqilteairn wegddiktlg
      301 nvtymsqvli qcagseekne rylllfpnvl lmlsasprms gfiyqgklpt tgmtitkled
      361 senhrnafei sgsmierilv scnnqqdlqe wvehlqkqtk vtsvgnptik phsvpshtlp
      421 shpvtpsskh adskpapltp ayhtlphpsh hgtphttinw gpleppktpk pwslsclrpa
      481 pplrpsaalc ykevrsldhs nsqmtdlsks pktmkkllpk rkperkpsde efasrkstaa
      541 leedaqilkv ieayctsakt rqtlnstwqg tdlmhnhvla dddqpsldsl grrsslsrle
      601 psdlsedsdy dsiwtahsyr mgstsrsrke sapqvllpee ekiiveetks ngqtvieeks
      661 lvdtvyalkd evqelrqdnk kmkksleeeq rarkdleklv rkvlknmndp awdetnl
//
LOCUS       XP_047286696             717 aa            linear   PRI 05-AUG-2025
DEFINITION  rho guanine nucleotide exchange factor 7 isoform X13 [Homo
            sapiens].
ACCESSION   XP_047286696
VERSION     XP_047286696.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430740.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..717
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..717
                     /product="rho guanine nucleotide exchange factor 7 isoform
                     X13"
                     /calculated_mol_wt=81058
     Region          10..63
                     /region_name="SH3_betaPIX"
                     /note="Src Homology 3 domain of beta-Pak Interactive
                     eXchange factor; cd12061"
                     /db_xref="CDD:212994"
     Site            order(15,17,20,23..24,39,41..43,54,56,58..59)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212994"
     Region          94..271
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
                     (DH) domain. It appears that PH domains invariably occur
                     C-terminal to RhoGEF/DH domains; cd00160"
                     /db_xref="CDD:238091"
     Site            order(100,104,198,222..223,226..227,229..230,233..234,
                     237..238,241,267,271)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          302..400
                     /region_name="PH_Cool_Pix"
                     /note="Cloned out of library/PAK-interactive exchange
                     factor pleckstrin homology (PH) domain; cd01225"
                     /db_xref="CDD:269932"
     Region          <407..490
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          460..562
                     /region_name="RhoGEF67_u2"
                     /note="Unstructured region two on RhoGEF 6 and 7;
                     pfam16614"
                     /db_xref="CDD:465200"
     Region          632..716
                     /region_name="betaPIX_CC"
                     /note="betaPIX coiled coil; pfam16523"
                     /db_xref="CDD:465158"
     CDS             1..717
                     /gene="ARHGEF7"
                     /gene_synonym="BETA-PIX; COOL-1; COOL1; Nbla10314; P50;
                     P50BP; P85; P85COOL1; P85SPR; PAK3; PIXB"
                     /coded_by="XM_047430740.1:1138..3291"
                     /db_xref="GeneID:8874"
                     /db_xref="HGNC:HGNC:15607"
                     /db_xref="MIM:605477"
ORIGIN      
        1 mtdnsnnqlv vrakfnfqqt nedelsfskg dvihvtrvee ggwwegtlng rtgwfpsnyv
       61 revkasekpv spksgtlksp pkgfdttain ksyynvvlqn ileteneysk elqtvlstyl
      121 rplqtsekls sanisylmgn leeicsfqqm lvqsleectk lpeaqqrvgg cflnlmpqmk
      181 tlyltycanh psavnvlteh seelgefmet kgasspgilv lttglskpfm rldkyptllk
      241 elerhmedyh tdrqdiqksm aafknlsaqc qevrkrkele lqilteairn wegddiktlg
      301 nvtymsqvli qcagseekne rylllfpnvl lmlsasprms gfiyqgklpt tgmtitkled
      361 senhrnafei sgsmierilv scnnqqdlqe wvehlqkqtk vtsvgnptik phsvpshtlp
      421 shpvtpsskh adskpapltp ayhtlphpsh hgtphttinw gpleppktpk pwslsclrpa
      481 pplrpsaalc ykevrsldhs nsqmtdlsks pktmkkllpk rkperkpsde efasrkstaa
      541 leedaqilkv ieayctsakt rqtlnstwqg tdlmhnhvla dddqpsldsl grrsslsrle
      601 psdlsedsdy dsiwtahsyr mgstsrsrke sapqvllpee ekiiveetks ngqtvieeks
      661 lvdtvyalkd evqelrqdnk kmkksleeeq rarkdleklv rkvlknmndp awdetnl
//
LOCUS       XP_047286697             705 aa            linear   PRI 05-AUG-2025
DEFINITION  rho guanine nucleotide exchange factor 7 isoform X14 [Homo
            sapiens].
ACCESSION   XP_047286697
VERSION     XP_047286697.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430741.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..705
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..705
                     /product="rho guanine nucleotide exchange factor 7 isoform
                     X14"
                     /calculated_mol_wt=79702
     Region          10..63
                     /region_name="SH3_betaPIX"
                     /note="Src Homology 3 domain of beta-Pak Interactive
                     eXchange factor; cd12061"
                     /db_xref="CDD:212994"
     Site            order(15,17,20,23..24,39,41..43,54,56,58..59)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212994"
     Region          94..271
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
                     (DH) domain. It appears that PH domains invariably occur
                     C-terminal to RhoGEF/DH domains; cd00160"
                     /db_xref="CDD:238091"
     Site            order(100,104,198,222..223,226..227,229..230,233..234,
                     237..238,241,267,271)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          302..400
                     /region_name="PH_Cool_Pix"
                     /note="Cloned out of library/PAK-interactive exchange
                     factor pleckstrin homology (PH) domain; cd01225"
                     /db_xref="CDD:269932"
     Region          460..550
                     /region_name="RhoGEF67_u2"
                     /note="Unstructured region two on RhoGEF 6 and 7;
                     pfam16614"
                     /db_xref="CDD:465200"
     Region          620..704
                     /region_name="betaPIX_CC"
                     /note="betaPIX coiled coil; pfam16523"
                     /db_xref="CDD:465158"
     CDS             1..705
                     /gene="ARHGEF7"
                     /gene_synonym="BETA-PIX; COOL-1; COOL1; Nbla10314; P50;
                     P50BP; P85; P85COOL1; P85SPR; PAK3; PIXB"
                     /coded_by="XM_047430741.1:147..2264"
                     /db_xref="GeneID:8874"
                     /db_xref="HGNC:HGNC:15607"
                     /db_xref="MIM:605477"
ORIGIN      
        1 mtdnsnnqlv vrakfnfqqt nedelsfskg dvihvtrvee ggwwegtlng rtgwfpsnyv
       61 revkasekpv spksgtlksp pkgfdttain ksyynvvlqn ileteneysk elqtvlstyl
      121 rplqtsekls sanisylmgn leeicsfqqm lvqsleectk lpeaqqrvgg cflnlmpqmk
      181 tlyltycanh psavnvlteh seelgefmet kgasspgilv lttglskpfm rldkyptllk
      241 elerhmedyh tdrqdiqksm aafknlsaqc qevrkrkele lqilteairn wegddiktlg
      301 nvtymsqvli qcagseekne rylllfpnvl lmlsasprms gfiyqgklpt tgmtitkled
      361 senhrnafei sgsmierilv scnnqqdlqe wvehlqkqtk vtsvgnptik phsvpshtlp
      421 shpvtpsskh adskpapltp ayhtlphpsh hgtphttinw gpleppktpk pwslsclrpa
      481 pplrpsaalc ykedlskspk tmkkllpkrk perkpsdeef asrkstaale edaqilkvie
      541 ayctsaktrq tlnstwqgtd lmhnhvladd dqpsldslgr rsslsrleps dlsedsdyds
      601 iwtahsyrmg stsrsrkesa pqvllpeeek iiveetksng qtvieekslv dtvyalkdev
      661 qelrqdnkkm kksleeeqra rkdleklvrk vlknmndpaw detnl
//
LOCUS       XP_047286698             658 aa            linear   PRI 05-AUG-2025
DEFINITION  rho guanine nucleotide exchange factor 7 isoform X15 [Homo
            sapiens].
ACCESSION   XP_047286698
VERSION     XP_047286698.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430742.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..658
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..658
                     /product="rho guanine nucleotide exchange factor 7 isoform
                     X15"
                     /calculated_mol_wt=74366
     Region          10..63
                     /region_name="SH3_betaPIX"
                     /note="Src Homology 3 domain of beta-Pak Interactive
                     eXchange factor; cd12061"
                     /db_xref="CDD:212994"
     Site            order(15,17,20,23..24,39,41..43,54,56,58..59)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212994"
     Region          94..271
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
                     (DH) domain. It appears that PH domains invariably occur
                     C-terminal to RhoGEF/DH domains; cd00160"
                     /db_xref="CDD:238091"
     Site            order(100,104,198,222..223,226..227,229..230,233..234,
                     237..238,241,267,271)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          302..400
                     /region_name="PH_Cool_Pix"
                     /note="Cloned out of library/PAK-interactive exchange
                     factor pleckstrin homology (PH) domain; cd01225"
                     /db_xref="CDD:269932"
     Region          <407..490
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          460..562
                     /region_name="RhoGEF67_u2"
                     /note="Unstructured region two on RhoGEF 6 and 7;
                     pfam16614"
                     /db_xref="CDD:465200"
     Region          573..657
                     /region_name="betaPIX_CC"
                     /note="betaPIX coiled coil; pfam16523"
                     /db_xref="CDD:465158"
     CDS             1..658
                     /gene="ARHGEF7"
                     /gene_synonym="BETA-PIX; COOL-1; COOL1; Nbla10314; P50;
                     P50BP; P85; P85COOL1; P85SPR; PAK3; PIXB"
                     /coded_by="XM_047430742.1:388..2364"
                     /db_xref="GeneID:8874"
                     /db_xref="HGNC:HGNC:15607"
                     /db_xref="MIM:605477"
ORIGIN      
        1 mtdnsnnqlv vrakfnfqqt nedelsfskg dvihvtrvee ggwwegtlng rtgwfpsnyv
       61 revkasekpv spksgtlksp pkgfdttain ksyynvvlqn ileteneysk elqtvlstyl
      121 rplqtsekls sanisylmgn leeicsfqqm lvqsleectk lpeaqqrvgg cflnlmpqmk
      181 tlyltycanh psavnvlteh seelgefmet kgasspgilv lttglskpfm rldkyptllk
      241 elerhmedyh tdrqdiqksm aafknlsaqc qevrkrkele lqilteairn wegddiktlg
      301 nvtymsqvli qcagseekne rylllfpnvl lmlsasprms gfiyqgklpt tgmtitkled
      361 senhrnafei sgsmierilv scnnqqdlqe wvehlqkqtk vtsvgnptik phsvpshtlp
      421 shpvtpsskh adskpapltp ayhtlphpsh hgtphttinw gpleppktpk pwslsclrpa
      481 pplrpsaalc ykevrsldhs nsqmtdlsks pktmkkllpk rkperkpsde efasrkstaa
      541 leedaqilkv ieayctsakt rqtlnsssrk esapqvllpe eekiiveetk sngqtvieek
      601 slvdtvyalk devqelrqdn kkmkksleee qrarkdlekl vrkvlknmnd pawdetnl
//
LOCUS       XP_016876311             658 aa            linear   PRI 05-AUG-2025
DEFINITION  rho guanine nucleotide exchange factor 7 isoform X15 [Homo
            sapiens].
ACCESSION   XP_016876311
VERSION     XP_016876311.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020822.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..658
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..658
                     /product="rho guanine nucleotide exchange factor 7 isoform
                     X15"
                     /calculated_mol_wt=74366
     Region          10..63
                     /region_name="SH3_betaPIX"
                     /note="Src Homology 3 domain of beta-Pak Interactive
                     eXchange factor; cd12061"
                     /db_xref="CDD:212994"
     Site            order(15,17,20,23..24,39,41..43,54,56,58..59)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212994"
     Region          94..271
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
                     (DH) domain. It appears that PH domains invariably occur
                     C-terminal to RhoGEF/DH domains; cd00160"
                     /db_xref="CDD:238091"
     Site            order(100,104,198,222..223,226..227,229..230,233..234,
                     237..238,241,267,271)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          302..400
                     /region_name="PH_Cool_Pix"
                     /note="Cloned out of library/PAK-interactive exchange
                     factor pleckstrin homology (PH) domain; cd01225"
                     /db_xref="CDD:269932"
     Region          <407..490
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          460..562
                     /region_name="RhoGEF67_u2"
                     /note="Unstructured region two on RhoGEF 6 and 7;
                     pfam16614"
                     /db_xref="CDD:465200"
     Region          573..657
                     /region_name="betaPIX_CC"
                     /note="betaPIX coiled coil; pfam16523"
                     /db_xref="CDD:465158"
     CDS             1..658
                     /gene="ARHGEF7"
                     /gene_synonym="BETA-PIX; COOL-1; COOL1; Nbla10314; P50;
                     P50BP; P85; P85COOL1; P85SPR; PAK3; PIXB"
                     /coded_by="XM_017020822.2:147..2123"
                     /db_xref="GeneID:8874"
                     /db_xref="HGNC:HGNC:15607"
                     /db_xref="MIM:605477"
ORIGIN      
        1 mtdnsnnqlv vrakfnfqqt nedelsfskg dvihvtrvee ggwwegtlng rtgwfpsnyv
       61 revkasekpv spksgtlksp pkgfdttain ksyynvvlqn ileteneysk elqtvlstyl
      121 rplqtsekls sanisylmgn leeicsfqqm lvqsleectk lpeaqqrvgg cflnlmpqmk
      181 tlyltycanh psavnvlteh seelgefmet kgasspgilv lttglskpfm rldkyptllk
      241 elerhmedyh tdrqdiqksm aafknlsaqc qevrkrkele lqilteairn wegddiktlg
      301 nvtymsqvli qcagseekne rylllfpnvl lmlsasprms gfiyqgklpt tgmtitkled
      361 senhrnafei sgsmierilv scnnqqdlqe wvehlqkqtk vtsvgnptik phsvpshtlp
      421 shpvtpsskh adskpapltp ayhtlphpsh hgtphttinw gpleppktpk pwslsclrpa
      481 pplrpsaalc ykevrsldhs nsqmtdlsks pktmkkllpk rkperkpsde efasrkstaa
      541 leedaqilkv ieayctsakt rqtlnsssrk esapqvllpe eekiiveetk sngqtvieek
      601 slvdtvyalk devqelrqdn kkmkksleee qrarkdlekl vrkvlknmnd pawdetnl
//
LOCUS       XP_047286699             646 aa            linear   PRI 05-AUG-2025
DEFINITION  rho guanine nucleotide exchange factor 7 isoform X16 [Homo
            sapiens].
ACCESSION   XP_047286699
VERSION     XP_047286699.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430743.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..646
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..646
                     /product="rho guanine nucleotide exchange factor 7 isoform
                     X16"
                     /calculated_mol_wt=73009
     Region          10..63
                     /region_name="SH3_betaPIX"
                     /note="Src Homology 3 domain of beta-Pak Interactive
                     eXchange factor; cd12061"
                     /db_xref="CDD:212994"
     Site            order(15,17,20,23..24,39,41..43,54,56,58..59)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212994"
     Region          94..271
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
                     (DH) domain. It appears that PH domains invariably occur
                     C-terminal to RhoGEF/DH domains; cd00160"
                     /db_xref="CDD:238091"
     Site            order(100,104,198,222..223,226..227,229..230,233..234,
                     237..238,241,267,271)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          302..400
                     /region_name="PH_Cool_Pix"
                     /note="Cloned out of library/PAK-interactive exchange
                     factor pleckstrin homology (PH) domain; cd01225"
                     /db_xref="CDD:269932"
     Region          460..550
                     /region_name="RhoGEF67_u2"
                     /note="Unstructured region two on RhoGEF 6 and 7;
                     pfam16614"
                     /db_xref="CDD:465200"
     Region          561..645
                     /region_name="betaPIX_CC"
                     /note="betaPIX coiled coil; pfam16523"
                     /db_xref="CDD:465158"
     CDS             1..646
                     /gene="ARHGEF7"
                     /gene_synonym="BETA-PIX; COOL-1; COOL1; Nbla10314; P50;
                     P50BP; P85; P85COOL1; P85SPR; PAK3; PIXB"
                     /coded_by="XM_047430743.1:268..2208"
                     /db_xref="GeneID:8874"
                     /db_xref="HGNC:HGNC:15607"
                     /db_xref="MIM:605477"
ORIGIN      
        1 mtdnsnnqlv vrakfnfqqt nedelsfskg dvihvtrvee ggwwegtlng rtgwfpsnyv
       61 revkasekpv spksgtlksp pkgfdttain ksyynvvlqn ileteneysk elqtvlstyl
      121 rplqtsekls sanisylmgn leeicsfqqm lvqsleectk lpeaqqrvgg cflnlmpqmk
      181 tlyltycanh psavnvlteh seelgefmet kgasspgilv lttglskpfm rldkyptllk
      241 elerhmedyh tdrqdiqksm aafknlsaqc qevrkrkele lqilteairn wegddiktlg
      301 nvtymsqvli qcagseekne rylllfpnvl lmlsasprms gfiyqgklpt tgmtitkled
      361 senhrnafei sgsmierilv scnnqqdlqe wvehlqkqtk vtsvgnptik phsvpshtlp
      421 shpvtpsskh adskpapltp ayhtlphpsh hgtphttinw gpleppktpk pwslsclrpa
      481 pplrpsaalc ykedlskspk tmkkllpkrk perkpsdeef asrkstaale edaqilkvie
      541 ayctsaktrq tlnsssrkes apqvllpeee kiiveetksn gqtvieeksl vdtvyalkde
      601 vqelrqdnkk mkksleeeqr arkdleklvr kvlknmndpa wdetnl
//
LOCUS       XP_047286700             646 aa            linear   PRI 05-AUG-2025
DEFINITION  rho guanine nucleotide exchange factor 7 isoform X16 [Homo
            sapiens].
ACCESSION   XP_047286700
VERSION     XP_047286700.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430744.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..646
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..646
                     /product="rho guanine nucleotide exchange factor 7 isoform
                     X16"
                     /calculated_mol_wt=73009
     Region          10..63
                     /region_name="SH3_betaPIX"
                     /note="Src Homology 3 domain of beta-Pak Interactive
                     eXchange factor; cd12061"
                     /db_xref="CDD:212994"
     Site            order(15,17,20,23..24,39,41..43,54,56,58..59)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212994"
     Region          94..271
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
                     (DH) domain. It appears that PH domains invariably occur
                     C-terminal to RhoGEF/DH domains; cd00160"
                     /db_xref="CDD:238091"
     Site            order(100,104,198,222..223,226..227,229..230,233..234,
                     237..238,241,267,271)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          302..400
                     /region_name="PH_Cool_Pix"
                     /note="Cloned out of library/PAK-interactive exchange
                     factor pleckstrin homology (PH) domain; cd01225"
                     /db_xref="CDD:269932"
     Region          460..550
                     /region_name="RhoGEF67_u2"
                     /note="Unstructured region two on RhoGEF 6 and 7;
                     pfam16614"
                     /db_xref="CDD:465200"
     Region          561..645
                     /region_name="betaPIX_CC"
                     /note="betaPIX coiled coil; pfam16523"
                     /db_xref="CDD:465158"
     CDS             1..646
                     /gene="ARHGEF7"
                     /gene_synonym="BETA-PIX; COOL-1; COOL1; Nbla10314; P50;
                     P50BP; P85; P85COOL1; P85SPR; PAK3; PIXB"
                     /coded_by="XM_047430744.1:278..2218"
                     /db_xref="GeneID:8874"
                     /db_xref="HGNC:HGNC:15607"
                     /db_xref="MIM:605477"
ORIGIN      
        1 mtdnsnnqlv vrakfnfqqt nedelsfskg dvihvtrvee ggwwegtlng rtgwfpsnyv
       61 revkasekpv spksgtlksp pkgfdttain ksyynvvlqn ileteneysk elqtvlstyl
      121 rplqtsekls sanisylmgn leeicsfqqm lvqsleectk lpeaqqrvgg cflnlmpqmk
      181 tlyltycanh psavnvlteh seelgefmet kgasspgilv lttglskpfm rldkyptllk
      241 elerhmedyh tdrqdiqksm aafknlsaqc qevrkrkele lqilteairn wegddiktlg
      301 nvtymsqvli qcagseekne rylllfpnvl lmlsasprms gfiyqgklpt tgmtitkled
      361 senhrnafei sgsmierilv scnnqqdlqe wvehlqkqtk vtsvgnptik phsvpshtlp
      421 shpvtpsskh adskpapltp ayhtlphpsh hgtphttinw gpleppktpk pwslsclrpa
      481 pplrpsaalc ykedlskspk tmkkllpkrk perkpsdeef asrkstaale edaqilkvie
      541 ayctsaktrq tlnsssrkes apqvllpeee kiiveetksn gqtvieeksl vdtvyalkde
      601 vqelrqdnkk mkksleeeqr arkdleklvr kvlknmndpa wdetnl
//
LOCUS       XP_047286701             646 aa            linear   PRI 05-AUG-2025
DEFINITION  rho guanine nucleotide exchange factor 7 isoform X16 [Homo
            sapiens].
ACCESSION   XP_047286701
VERSION     XP_047286701.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430745.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..646
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..646
                     /product="rho guanine nucleotide exchange factor 7 isoform
                     X16"
                     /calculated_mol_wt=73009
     Region          10..63
                     /region_name="SH3_betaPIX"
                     /note="Src Homology 3 domain of beta-Pak Interactive
                     eXchange factor; cd12061"
                     /db_xref="CDD:212994"
     Site            order(15,17,20,23..24,39,41..43,54,56,58..59)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212994"
     Region          94..271
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
                     (DH) domain. It appears that PH domains invariably occur
                     C-terminal to RhoGEF/DH domains; cd00160"
                     /db_xref="CDD:238091"
     Site            order(100,104,198,222..223,226..227,229..230,233..234,
                     237..238,241,267,271)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          302..400
                     /region_name="PH_Cool_Pix"
                     /note="Cloned out of library/PAK-interactive exchange
                     factor pleckstrin homology (PH) domain; cd01225"
                     /db_xref="CDD:269932"
     Region          460..550
                     /region_name="RhoGEF67_u2"
                     /note="Unstructured region two on RhoGEF 6 and 7;
                     pfam16614"
                     /db_xref="CDD:465200"
     Region          561..645
                     /region_name="betaPIX_CC"
                     /note="betaPIX coiled coil; pfam16523"
                     /db_xref="CDD:465158"
     CDS             1..646
                     /gene="ARHGEF7"
                     /gene_synonym="BETA-PIX; COOL-1; COOL1; Nbla10314; P50;
                     P50BP; P85; P85COOL1; P85SPR; PAK3; PIXB"
                     /coded_by="XM_047430745.1:388..2328"
                     /db_xref="GeneID:8874"
                     /db_xref="HGNC:HGNC:15607"
                     /db_xref="MIM:605477"
ORIGIN      
        1 mtdnsnnqlv vrakfnfqqt nedelsfskg dvihvtrvee ggwwegtlng rtgwfpsnyv
       61 revkasekpv spksgtlksp pkgfdttain ksyynvvlqn ileteneysk elqtvlstyl
      121 rplqtsekls sanisylmgn leeicsfqqm lvqsleectk lpeaqqrvgg cflnlmpqmk
      181 tlyltycanh psavnvlteh seelgefmet kgasspgilv lttglskpfm rldkyptllk
      241 elerhmedyh tdrqdiqksm aafknlsaqc qevrkrkele lqilteairn wegddiktlg
      301 nvtymsqvli qcagseekne rylllfpnvl lmlsasprms gfiyqgklpt tgmtitkled
      361 senhrnafei sgsmierilv scnnqqdlqe wvehlqkqtk vtsvgnptik phsvpshtlp
      421 shpvtpsskh adskpapltp ayhtlphpsh hgtphttinw gpleppktpk pwslsclrpa
      481 pplrpsaalc ykedlskspk tmkkllpkrk perkpsdeef asrkstaale edaqilkvie
      541 ayctsaktrq tlnsssrkes apqvllpeee kiiveetksn gqtvieeksl vdtvyalkde
      601 vqelrqdnkk mkksleeeqr arkdleklvr kvlknmndpa wdetnl
//
LOCUS       XP_047286702             580 aa            linear   PRI 05-AUG-2025
DEFINITION  rho guanine nucleotide exchange factor 7 isoform X17 [Homo
            sapiens].
ACCESSION   XP_047286702
VERSION     XP_047286702.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430746.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..580
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..580
                     /product="rho guanine nucleotide exchange factor 7 isoform
                     X17"
                     /calculated_mol_wt=65864
     Region          <7..134
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
                     (DH) domain. It appears that PH domains invariably occur
                     C-terminal to RhoGEF/DH domains; cl02571"
                     /db_xref="CDD:470622"
     Site            order(61,85..86,89..90,92..93,96..97,100..101,104,130,134)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          165..263
                     /region_name="PH_Cool_Pix"
                     /note="Cloned out of library/PAK-interactive exchange
                     factor pleckstrin homology (PH) domain; cd01225"
                     /db_xref="CDD:269932"
     Region          <270..353
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          323..425
                     /region_name="RhoGEF67_u2"
                     /note="Unstructured region two on RhoGEF 6 and 7;
                     pfam16614"
                     /db_xref="CDD:465200"
     Region          495..579
                     /region_name="betaPIX_CC"
                     /note="betaPIX coiled coil; pfam16523"
                     /db_xref="CDD:465158"
     CDS             1..580
                     /gene="ARHGEF7"
                     /gene_synonym="BETA-PIX; COOL-1; COOL1; Nbla10314; P50;
                     P50BP; P85; P85COOL1; P85SPR; PAK3; PIXB"
                     /coded_by="XM_047430746.1:26..1768"
                     /db_xref="GeneID:8874"
                     /db_xref="HGNC:HGNC:15607"
                     /db_xref="MIM:605477"
ORIGIN      
        1 mhqehqieql strrntflri rirlpeaqqr vggcflnlmp qmktlyltyc anhpsavnvl
       61 tehseelgef metkgasspg ilvlttglsk pfmrldkypt llkelerhme dyhtdrqdiq
      121 ksmaafknls aqcqevrkrk elelqiltea irnwegddik tlgnvtymsq vliqcagsee
      181 knerylllfp nvllmlsasp rmsgfiyqgk lpttgmtitk ledsenhrna feisgsmier
      241 ilvscnnqqd lqewvehlqk qtkvtsvgnp tikphsvpsh tlpshpvtps skhadskpap
      301 ltpayhtlph pshhgtphtt inwgpleppk tpkpwslscl rpapplrpsa alcykevrsl
      361 dhsnsqmtdl skspktmkkl lpkrkperkp sdeefasrks taaleedaqi lkvieaycts
      421 aktrqtlnst wqgtdlmhnh vladddqpsl dslgrrssls rlepsdlsed sdydsiwtah
      481 syrmgstsrs rkesapqvll peeekiivee tksngqtvie ekslvdtvya lkdevqelrq
      541 dnkkmkksle eeqrarkdle klvrkvlknm ndpawdetnl
//
LOCUS       XP_011519435             504 aa            linear   PRI 05-AUG-2025
DEFINITION  rho guanine nucleotide exchange factor 7 isoform X18 [Homo
            sapiens].
ACCESSION   XP_011519435
VERSION     XP_011519435.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521133.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..504
                     /product="rho guanine nucleotide exchange factor 7 isoform
                     X18"
                     /calculated_mol_wt=56595
     Region          3..115
                     /region_name="CH_betaPIX"
                     /note="calponin homology (CH) domain found in beta-Pak
                     Interactive eXchange factor; cd21266"
                     /db_xref="CDD:409115"
     Site            order(3,7,65,67..68,71..72,74,82..90,96,98..99,101..102,
                     105..106,109)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409115"
     Region          117..163
                     /region_name="RhoGEF67_u1"
                     /note="Unstructured region one on RhoGEF 6 and 7;
                     pfam16615"
                     /db_xref="CDD:465201"
     Region          167..220
                     /region_name="SH3_betaPIX"
                     /note="Src Homology 3 domain of beta-Pak Interactive
                     eXchange factor; cd12061"
                     /db_xref="CDD:212994"
     Site            order(172,174,177,180..181,196,198..200,211,213,215..216)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212994"
     Region          251..428
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
                     (DH) domain. It appears that PH domains invariably occur
                     C-terminal to RhoGEF/DH domains; cd00160"
                     /db_xref="CDD:238091"
     Site            order(257,261,355,379..380,383..384,386..387,390..391,
                     394..395,398,424,428)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          459..>503
                     /region_name="PH-like"
                     /note="Pleckstrin homology-like domain; cl17171"
                     /db_xref="CDD:473070"
     CDS             1..504
                     /gene="ARHGEF7"
                     /gene_synonym="BETA-PIX; COOL-1; COOL1; Nbla10314; P50;
                     P50BP; P85; P85COOL1; P85SPR; PAK3; PIXB"
                     /coded_by="XM_011521133.3:909..2423"
                     /db_xref="GeneID:8874"
                     /db_xref="HGNC:HGNC:15607"
                     /db_xref="MIM:605477"
ORIGIN      
        1 mnsaeqtvtw litlgvlesp kktisdpegf lqaslkdgvv lcrllerllp gtiekvypep
       61 rseseclsni reflrgcgas lrletfdand lyqgqnfnkv lsslvtlnkv tadiglgsds
      121 vcarpsshri ksfdslgsqs lhtrtsklfq gqyrsldmtd nsnnqlvvra kfnfqqtned
      181 elsfskgdvi hvtrveeggw wegtlngrtg wfpsnyvrev kasekpvspk sgtlksppkg
      241 fdttainksy ynvvlqnile teneyskelq tvlstylrpl qtseklssan isylmgnlee
      301 icsfqqmlvq sleectklpe aqqrvggcfl nlmpqmktly ltycanhpsa vnvltehsee
      361 lgefmetkga sspgilvltt glskpfmrld kyptllkele rhmedyhtdr qdiqksmaaf
      421 knlsaqcqev rkrkelelqi lteairnweg ddiktlgnvt ymsqvliqca gseekneryl
      481 llfpnvllml sasprmsgfi yqga
//
LOCUS       XP_047286703             436 aa            linear   PRI 05-AUG-2025
DEFINITION  rho guanine nucleotide exchange factor 7 isoform X19 [Homo
            sapiens].
ACCESSION   XP_047286703
VERSION     XP_047286703.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430747.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..436
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..436
                     /product="rho guanine nucleotide exchange factor 7 isoform
                     X19"
                     /calculated_mol_wt=49264
     Region          10..63
                     /region_name="SH3_betaPIX"
                     /note="Src Homology 3 domain of beta-Pak Interactive
                     eXchange factor; cd12061"
                     /db_xref="CDD:212994"
     Site            order(15,17,20,23..24,39,41..43,54,56,58..59)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212994"
     Region          94..271
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
                     (DH) domain. It appears that PH domains invariably occur
                     C-terminal to RhoGEF/DH domains; cd00160"
                     /db_xref="CDD:238091"
     Site            order(100,104,198,222..223,226..227,229..230,233..234,
                     237..238,241,267,271)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          302..400
                     /region_name="PH_Cool_Pix"
                     /note="Cloned out of library/PAK-interactive exchange
                     factor pleckstrin homology (PH) domain; cd01225"
                     /db_xref="CDD:269932"
     CDS             1..436
                     /gene="ARHGEF7"
                     /gene_synonym="BETA-PIX; COOL-1; COOL1; Nbla10314; P50;
                     P50BP; P85; P85COOL1; P85SPR; PAK3; PIXB"
                     /coded_by="XM_047430747.1:363..1673"
                     /db_xref="GeneID:8874"
                     /db_xref="HGNC:HGNC:15607"
                     /db_xref="MIM:605477"
ORIGIN      
        1 mtdnsnnqlv vrakfnfqqt nedelsfskg dvihvtrvee ggwwegtlng rtgwfpsnyv
       61 revkasekpv spksgtlksp pkgfdttain ksyynvvlqn ileteneysk elqtvlstyl
      121 rplqtsekls sanisylmgn leeicsfqqm lvqsleectk lpeaqqrvgg cflnlmpqmk
      181 tlyltycanh psavnvlteh seelgefmet kgasspgilv lttglskpfm rldkyptllk
      241 elerhmedyh tdrqdiqksm aafknlsaqc qevrkrkele lqilteairn wegddiktlg
      301 nvtymsqvli qcagseekne rylllfpnvl lmlsasprms gfiyqgklpt tgmtitkled
      361 senhrnafei sgsmierilv scnnqqdlqe wvehlqkqtk vtsvgnptik phsvpshtvr
      421 twcfssfqtp gvasrg
//
LOCUS       XP_047286704             347 aa            linear   PRI 05-AUG-2025
DEFINITION  rho guanine nucleotide exchange factor 7 isoform X20 [Homo
            sapiens].
ACCESSION   XP_047286704
VERSION     XP_047286704.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430748.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..347
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..347
                     /product="rho guanine nucleotide exchange factor 7 isoform
                     X20"
                     /calculated_mol_wt=39274
     Region          10..63
                     /region_name="SH3_betaPIX"
                     /note="Src Homology 3 domain of beta-Pak Interactive
                     eXchange factor; cd12061"
                     /db_xref="CDD:212994"
     Site            order(15,17,20,23..24,39,41..43,54,56,58..59)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212994"
     Region          94..271
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
                     (DH) domain. It appears that PH domains invariably occur
                     C-terminal to RhoGEF/DH domains; cd00160"
                     /db_xref="CDD:238091"
     Site            order(100,104,198,222..223,226..227,229..230,233..234,
                     237..238,241,267,271)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          302..>346
                     /region_name="PH-like"
                     /note="Pleckstrin homology-like domain; cl17171"
                     /db_xref="CDD:473070"
     CDS             1..347
                     /gene="ARHGEF7"
                     /gene_synonym="BETA-PIX; COOL-1; COOL1; Nbla10314; P50;
                     P50BP; P85; P85COOL1; P85SPR; PAK3; PIXB"
                     /coded_by="XM_047430748.1:363..1406"
                     /db_xref="GeneID:8874"
                     /db_xref="HGNC:HGNC:15607"
                     /db_xref="MIM:605477"
ORIGIN      
        1 mtdnsnnqlv vrakfnfqqt nedelsfskg dvihvtrvee ggwwegtlng rtgwfpsnyv
       61 revkasekpv spksgtlksp pkgfdttain ksyynvvlqn ileteneysk elqtvlstyl
      121 rplqtsekls sanisylmgn leeicsfqqm lvqsleectk lpeaqqrvgg cflnlmpqmk
      181 tlyltycanh psavnvlteh seelgefmet kgasspgilv lttglskpfm rldkyptllk
      241 elerhmedyh tdrqdiqksm aafknlsaqc qevrkrkele lqilteairn wegddiktlg
      301 nvtymsqvli qcagseekne rylllfpnvl lmlsasprms gfiyqga
//
LOCUS       XP_047286706             347 aa            linear   PRI 05-AUG-2025
DEFINITION  rho guanine nucleotide exchange factor 7 isoform X20 [Homo
            sapiens].
ACCESSION   XP_047286706
VERSION     XP_047286706.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430750.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..347
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..347
                     /product="rho guanine nucleotide exchange factor 7 isoform
                     X20"
                     /calculated_mol_wt=39274
     Region          10..63
                     /region_name="SH3_betaPIX"
                     /note="Src Homology 3 domain of beta-Pak Interactive
                     eXchange factor; cd12061"
                     /db_xref="CDD:212994"
     Site            order(15,17,20,23..24,39,41..43,54,56,58..59)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212994"
     Region          94..271
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
                     (DH) domain. It appears that PH domains invariably occur
                     C-terminal to RhoGEF/DH domains; cd00160"
                     /db_xref="CDD:238091"
     Site            order(100,104,198,222..223,226..227,229..230,233..234,
                     237..238,241,267,271)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          302..>346
                     /region_name="PH-like"
                     /note="Pleckstrin homology-like domain; cl17171"
                     /db_xref="CDD:473070"
     CDS             1..347
                     /gene="ARHGEF7"
                     /gene_synonym="BETA-PIX; COOL-1; COOL1; Nbla10314; P50;
                     P50BP; P85; P85COOL1; P85SPR; PAK3; PIXB"
                     /coded_by="XM_047430750.1:278..1321"
                     /db_xref="GeneID:8874"
                     /db_xref="HGNC:HGNC:15607"
                     /db_xref="MIM:605477"
ORIGIN      
        1 mtdnsnnqlv vrakfnfqqt nedelsfskg dvihvtrvee ggwwegtlng rtgwfpsnyv
       61 revkasekpv spksgtlksp pkgfdttain ksyynvvlqn ileteneysk elqtvlstyl
      121 rplqtsekls sanisylmgn leeicsfqqm lvqsleectk lpeaqqrvgg cflnlmpqmk
      181 tlyltycanh psavnvlteh seelgefmet kgasspgilv lttglskpfm rldkyptllk
      241 elerhmedyh tdrqdiqksm aafknlsaqc qevrkrkele lqilteairn wegddiktlg
      301 nvtymsqvli qcagseekne rylllfpnvl lmlsasprms gfiyqga
//
LOCUS       XP_047286707             347 aa            linear   PRI 05-AUG-2025
DEFINITION  rho guanine nucleotide exchange factor 7 isoform X20 [Homo
            sapiens].
ACCESSION   XP_047286707
VERSION     XP_047286707.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430751.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..347
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..347
                     /product="rho guanine nucleotide exchange factor 7 isoform
                     X20"
                     /calculated_mol_wt=39274
     Region          10..63
                     /region_name="SH3_betaPIX"
                     /note="Src Homology 3 domain of beta-Pak Interactive
                     eXchange factor; cd12061"
                     /db_xref="CDD:212994"
     Site            order(15,17,20,23..24,39,41..43,54,56,58..59)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212994"
     Region          94..271
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
                     (DH) domain. It appears that PH domains invariably occur
                     C-terminal to RhoGEF/DH domains; cd00160"
                     /db_xref="CDD:238091"
     Site            order(100,104,198,222..223,226..227,229..230,233..234,
                     237..238,241,267,271)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          302..>346
                     /region_name="PH-like"
                     /note="Pleckstrin homology-like domain; cl17171"
                     /db_xref="CDD:473070"
     CDS             1..347
                     /gene="ARHGEF7"
                     /gene_synonym="BETA-PIX; COOL-1; COOL1; Nbla10314; P50;
                     P50BP; P85; P85COOL1; P85SPR; PAK3; PIXB"
                     /coded_by="XM_047430751.1:147..1190"
                     /db_xref="GeneID:8874"
                     /db_xref="HGNC:HGNC:15607"
                     /db_xref="MIM:605477"
ORIGIN      
        1 mtdnsnnqlv vrakfnfqqt nedelsfskg dvihvtrvee ggwwegtlng rtgwfpsnyv
       61 revkasekpv spksgtlksp pkgfdttain ksyynvvlqn ileteneysk elqtvlstyl
      121 rplqtsekls sanisylmgn leeicsfqqm lvqsleectk lpeaqqrvgg cflnlmpqmk
      181 tlyltycanh psavnvlteh seelgefmet kgasspgilv lttglskpfm rldkyptllk
      241 elerhmedyh tdrqdiqksm aafknlsaqc qevrkrkele lqilteairn wegddiktlg
      301 nvtymsqvli qcagseekne rylllfpnvl lmlsasprms gfiyqga
//
LOCUS       XP_011533153             569 aa            linear   PRI 05-AUG-2025
DEFINITION  cell division cycle protein 16 homolog isoform X1 [Homo sapiens].
ACCESSION   XP_011533153
VERSION     XP_011533153.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534851.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..569
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..569
                     /product="cell division cycle protein 16 homolog isoform
                     X1"
                     /calculated_mol_wt=65858
     Region          15..94
                     /region_name="ANAPC3"
                     /note="Anaphase-promoting complex, cyclosome, subunit 3;
                     pfam12895"
                     /db_xref="CDD:463743"
     Region          36..65
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          70..94
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          292..>471
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          298..329
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          334..362
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          396..422
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(398..399,402..403,405,429,432..433,436..437,
                     439..440,463,466..467,470..471)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          427..457
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..569
                     /gene="CDC16"
                     /gene_synonym="ANAPC6; APC6; CDC16Hs; CUT9"
                     /coded_by="XM_011534851.3:189..1898"
                     /db_xref="GeneID:8881"
                     /db_xref="HGNC:HGNC:1720"
                     /db_xref="MIM:603461"
ORIGIN      
        1 mnlerlrkrv rqyldqqqyq salfwadkva slsreepqdi ywlaqclylt aqyhraahal
       61 rsrkldklye acrylaarch yaakehqqal dvldmeepin krlfekylkd esgfkdpssd
      121 wemsqssiks sicllrgkiy daldnrtlat ysykealkld vycfeafdll tshhmltaqe
      181 ekelleslpl sklcneeqel lrflfenklk kynkpsetvi pesvdglqen ldvvvslaer
      241 hyyncdfkmc ykltsvvmek dpfhasclpv higtlvelnk anelfylshk lvdlypsnpv
      301 swfavgcyyl mvghknehar rylskattle ktygpawiay ghsfaveseh dqamaayfta
      361 aqlmkgwkta ekwfldalek ikaignevtv dkwepllnnl ghvcrklkky aealdyhrqa
      421 lvlipqnast ysaigyihsl mgnfenavdy fhtalglrrd dtfsvtmlgh ciemyigdse
      481 ayigadikdk lkcydfdvht mktlkniisp pwdfrefeve kqtaeetglt pletsrktpd
      541 srpsleetfe iemnesdmml etsmsdhst
//
LOCUS       XP_016876319             569 aa            linear   PRI 05-AUG-2025
DEFINITION  cell division cycle protein 16 homolog isoform X1 [Homo sapiens].
ACCESSION   XP_016876319
VERSION     XP_016876319.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020830.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..569
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..569
                     /product="cell division cycle protein 16 homolog isoform
                     X1"
                     /calculated_mol_wt=65858
     Region          15..94
                     /region_name="ANAPC3"
                     /note="Anaphase-promoting complex, cyclosome, subunit 3;
                     pfam12895"
                     /db_xref="CDD:463743"
     Region          36..65
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          70..94
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          292..>471
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          298..329
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          334..362
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          396..422
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(398..399,402..403,405,429,432..433,436..437,
                     439..440,463,466..467,470..471)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          427..457
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..569
                     /gene="CDC16"
                     /gene_synonym="ANAPC6; APC6; CDC16Hs; CUT9"
                     /coded_by="XM_017020830.3:189..1898"
                     /db_xref="GeneID:8881"
                     /db_xref="HGNC:HGNC:1720"
                     /db_xref="MIM:603461"
ORIGIN      
        1 mnlerlrkrv rqyldqqqyq salfwadkva slsreepqdi ywlaqclylt aqyhraahal
       61 rsrkldklye acrylaarch yaakehqqal dvldmeepin krlfekylkd esgfkdpssd
      121 wemsqssiks sicllrgkiy daldnrtlat ysykealkld vycfeafdll tshhmltaqe
      181 ekelleslpl sklcneeqel lrflfenklk kynkpsetvi pesvdglqen ldvvvslaer
      241 hyyncdfkmc ykltsvvmek dpfhasclpv higtlvelnk anelfylshk lvdlypsnpv
      301 swfavgcyyl mvghknehar rylskattle ktygpawiay ghsfaveseh dqamaayfta
      361 aqlmkgwkta ekwfldalek ikaignevtv dkwepllnnl ghvcrklkky aealdyhrqa
      421 lvlipqnast ysaigyihsl mgnfenavdy fhtalglrrd dtfsvtmlgh ciemyigdse
      481 ayigadikdk lkcydfdvht mktlkniisp pwdfrefeve kqtaeetglt pletsrktpd
      541 srpsleetfe iemnesdmml etsmsdhst
//
LOCUS       XP_011533155             539 aa            linear   PRI 05-AUG-2025
DEFINITION  cell division cycle protein 16 homolog isoform X2 [Homo sapiens].
ACCESSION   XP_011533155
VERSION     XP_011533155.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011534853.3
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 2% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..539
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..539
                     /product="cell division cycle protein 16 homolog isoform
                     X2"
                     /calculated_mol_wt=62178
     Region          15..94
                     /region_name="ANAPC3"
                     /note="Anaphase-promoting complex, cyclosome, subunit 3;
                     pfam12895"
                     /db_xref="CDD:463743"
     Region          36..65
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          70..94
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          275..>440
                     /region_name="Spy"
                     /note="Predicted O-linked N-acetylglucosamine transferase,
                     SPINDLY family [Posttranslational modification, protein
                     turnover, chaperones]; COG3914"
                     /db_xref="CDD:443119"
     Region          298..329
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          336..362
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          367..397
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          373..>522
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          402..430
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          447..473
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(449..450,453..454,456,480,483..484,487..488,
                     490..491,514,517..518,521..522)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          478..508
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..539
                     /gene="CDC16"
                     /gene_synonym="ANAPC6; APC6; CDC16Hs; CUT9"
                     /coded_by="XM_011534853.3:189..1808"
                     /db_xref="GeneID:8881"
                     /db_xref="HGNC:HGNC:1720"
                     /db_xref="MIM:603461"
ORIGIN      
        1 mnlerlrkrv rqyldqqqyq salfwadkva slsreepqdi ywlaqclylt aqyhraahal
       61 rsrkldklye acrylaarch yaakehqqal dvldmeepin krlfekylkd esgfkdpssd
      121 wemsqssiks sicllrgkiy daldnrtlat ysykealkld vycfeafdll tshhmltaqe
      181 ekelleslpl sklcneeqel lrflfenklk kynkpsetvi pesvdglqen ldvvvslaer
      241 hyyncdfkmc ykltsvvmek dpfhasclpv higtlvelnk anelfylshk lvdlypsnpv
      301 swfavgcyyl mvghknehar rylskattle ktygpawiay ghsfaveseh dqamaayfta
      361 aqlmkgchlp mlyigleygl tnnsklaerf fsqalsiape dpfvmhevgv vafqngewkt
      421 aekwfldale kikaignevt vdkwepllnn lghvcrklkk yaealdyhrq alvlipqnas
      481 tysaigyihs lmgnfenavd yfhtalglrr ddtfsvtmlg hciemyigds eayiapnwk
//
LOCUS       XP_016876320             538 aa            linear   PRI 05-AUG-2025
DEFINITION  cell division cycle protein 16 homolog isoform X3 [Homo sapiens].
ACCESSION   XP_016876320
VERSION     XP_016876320.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020831.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..538
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..538
                     /product="cell division cycle protein 16 homolog isoform
                     X3"
                     /calculated_mol_wt=61994
     Region          15..94
                     /region_name="ANAPC3"
                     /note="Anaphase-promoting complex, cyclosome, subunit 3;
                     pfam12895"
                     /db_xref="CDD:463743"
     Region          36..65
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          70..94
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          275..>440
                     /region_name="Spy"
                     /note="Predicted O-linked N-acetylglucosamine transferase,
                     SPINDLY family [Posttranslational modification, protein
                     turnover, chaperones]; COG3914"
                     /db_xref="CDD:443119"
     Region          298..329
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          336..362
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          367..397
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          373..>522
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          402..430
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          447..473
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(449..450,453..454,456,480,483..484,487..488,
                     490..491,514,517..518,521..522)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          478..508
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..538
                     /gene="CDC16"
                     /gene_synonym="ANAPC6; APC6; CDC16Hs; CUT9"
                     /coded_by="XM_017020831.3:189..1805"
                     /db_xref="GeneID:8881"
                     /db_xref="HGNC:HGNC:1720"
                     /db_xref="MIM:603461"
ORIGIN      
        1 mnlerlrkrv rqyldqqqyq salfwadkva slsreepqdi ywlaqclylt aqyhraahal
       61 rsrkldklye acrylaarch yaakehqqal dvldmeepin krlfekylkd esgfkdpssd
      121 wemsqssiks sicllrgkiy daldnrtlat ysykealkld vycfeafdll tshhmltaqe
      181 ekelleslpl sklcneeqel lrflfenklk kynkpsetvi pesvdglqen ldvvvslaer
      241 hyyncdfkmc ykltsvvmek dpfhasclpv higtlvelnk anelfylshk lvdlypsnpv
      301 swfavgcyyl mvghknehar rylskattle ktygpawiay ghsfaveseh dqamaayfta
      361 aqlmkgchlp mlyigleygl tnnsklaerf fsqalsiape dpfvmhevgv vafqngewkt
      421 aekwfldale kikaignevt vdkwepllnn lghvcrklkk yaealdyhrq alvlipqnas
      481 tysaigyihs lmgnfenavd yfhtalglrr ddtfsvtmlg hciemyigds eayignlk
//
LOCUS       XP_047286709             537 aa            linear   PRI 05-AUG-2025
DEFINITION  cell division cycle protein 16 homolog isoform X4 [Homo sapiens].
ACCESSION   XP_047286709
VERSION     XP_047286709.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430753.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..537
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..537
                     /product="cell division cycle protein 16 homolog isoform
                     X4"
                     /calculated_mol_wt=61865
     Region          15..93
                     /region_name="ANAPC3"
                     /note="Anaphase-promoting complex, cyclosome, subunit 3;
                     pfam12895"
                     /db_xref="CDD:463743"
     Region          36..64
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          69..93
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          274..>439
                     /region_name="Spy"
                     /note="Predicted O-linked N-acetylglucosamine transferase,
                     SPINDLY family [Posttranslational modification, protein
                     turnover, chaperones]; COG3914"
                     /db_xref="CDD:443119"
     Region          297..328
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          335..361
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          366..396
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          372..>521
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          401..429
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          446..472
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(448..449,452..453,455,479,482..483,486..487,
                     489..490,513,516..517,520..521)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          477..507
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..537
                     /gene="CDC16"
                     /gene_synonym="ANAPC6; APC6; CDC16Hs; CUT9"
                     /coded_by="XM_047430753.1:189..1802"
                     /db_xref="GeneID:8881"
                     /db_xref="HGNC:HGNC:1720"
                     /db_xref="MIM:603461"
ORIGIN      
        1 mnlerlrkrv rqyldqqqyq salfwadkva slsrepqdiy wlaqclylta qyhraahalr
       61 srkldklyea crylaarchy aakehqqald vldmeepink rlfekylkde sgfkdpssdw
      121 emsqssikss icllrgkiyd aldnrtlaty sykealkldv ycfeafdllt shhmltaqee
      181 kelleslpls klcneeqell rflfenklkk ynkpsetvip esvdglqenl dvvvslaerh
      241 yyncdfkmcy kltsvvmekd pfhasclpvh igtlvelnka nelfylshkl vdlypsnpvs
      301 wfavgcyylm vghkneharr ylskattlek tygpawiayg hsfavesehd qamaayftaa
      361 qlmkgchlpm lyigleyglt nnsklaerff sqalsiaped pfvmhevgvv afqngewkta
      421 ekwfldalek ikaignevtv dkwepllnnl ghvcrklkky aealdyhrqa lvlipqnast
      481 ysaigyihsl mgnfenavdy fhtalglrrd dtfsvtmlgh ciemyigdse ayignlk
//
LOCUS       XP_047286710             526 aa            linear   PRI 05-AUG-2025
DEFINITION  cell division cycle protein 16 homolog isoform X5 [Homo sapiens].
ACCESSION   XP_047286710
VERSION     XP_047286710.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430754.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..526
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..526
                     /product="cell division cycle protein 16 homolog isoform
                     X5"
                     /calculated_mol_wt=60240
     Region          204..235
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          208..337
                     /region_name="BepA"
                     /note="Outer membrane protein chaperone/metalloprotease
                     BepA/YfgC, contains M48 and TPR domains [Cell
                     wall/membrane/envelope biogenesis, Posttranslational
                     modification, protein turnover, chaperones]; COG4783"
                     /db_xref="CDD:443813"
     Region          242..268
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          273..303
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          279..>428
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          308..336
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(309,312..313,316..317,319,343,355..356,359..360,
                     362..363,386,389..390,393..394,397)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          341..380
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          385..412
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..526
                     /gene="CDC16"
                     /gene_synonym="ANAPC6; APC6; CDC16Hs; CUT9"
                     /coded_by="XM_047430754.1:484..2064"
                     /db_xref="GeneID:8881"
                     /db_xref="HGNC:HGNC:1720"
                     /db_xref="MIM:603461"
ORIGIN      
        1 meepinkrlf ekylkdesgf kdpssdwems qssikssicl lrgkiydald nrtlatysyk
       61 ealkldvycf eafdlltshh mltaqeekel leslplsklc neeqellrfl fenklkkynk
      121 psetvipesv dglqenldvv vslaerhyyn cdfkmcyklt svvmekdpfh asclpvhigt
      181 lvelnkanel fylshklvdl ypsnpvswfa vgcyylmvgh kneharryls kattlektyg
      241 pawiayghsf avesehdqam aayftaaqlm kgchlpmlyi gleygltnns klaerffsqa
      301 lsiapedpfv mhevgvvafq ngewktaekw fldalekika ignevtvdkw epllnnlghv
      361 crklkkyaea ldyhrqalvl ipqnastysa igyihslmgn fenavdyfht alglrrddtf
      421 svtmlghcie myigdseayi gadikdklkc ydfdvhtmkt lkniisppwd frefevekqt
      481 aeetgltple tsrktpdsrp sleetfeiem nesdmmlets msdhst
//
LOCUS       XP_005266263             511 aa            linear   PRI 05-AUG-2025
DEFINITION  cell division cycle protein 16 homolog isoform X6 [Homo sapiens].
ACCESSION   XP_005266263
VERSION     XP_005266263.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266206.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..511
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..511
                     /product="cell division cycle protein 16 homolog isoform
                     X6"
                     /calculated_mol_wt=59037
     Region          15..94
                     /region_name="ANAPC3"
                     /note="Anaphase-promoting complex, cyclosome, subunit 3;
                     pfam12895"
                     /db_xref="CDD:463743"
     Region          36..65
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          70..94
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          <134..>502
                     /region_name="PEP_TPR_lipo"
                     /note="putative PEP-CTERM system TPR-repeat lipoprotein;
                     TIGR02917"
                     /db_xref="CDD:274350"
     Region          298..329
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          329..>506
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          336..362
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          367..397
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          402..430
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(403,406..407,410..411,413,437,449..450,453..454,
                     456..457,480,483..484,487..488,491)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          435..474
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          479..503
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..511
                     /gene="CDC16"
                     /gene_synonym="ANAPC6; APC6; CDC16Hs; CUT9"
                     /coded_by="XM_005266206.3:189..1724"
                     /db_xref="GeneID:8881"
                     /db_xref="HGNC:HGNC:1720"
                     /db_xref="MIM:603461"
ORIGIN      
        1 mnlerlrkrv rqyldqqqyq salfwadkva slsreepqdi ywlaqclylt aqyhraahal
       61 rsrkldklye acrylaarch yaakehqqal dvldmeepin krlfekylkd esgfkdpssd
      121 wemsqssiks sicllrgkiy daldnrtlat ysykealkld vycfeafdll tshhmltaqe
      181 ekelleslpl sklcneeqel lrflfenklk kynkpsetvi pesvdglqen ldvvvslaer
      241 hyyncdfkmc ykltsvvmek dpfhasclpv higtlvelnk anelfylshk lvdlypsnpv
      301 swfavgcyyl mvghknehar rylskattle ktygpawiay ghsfaveseh dqamaayfta
      361 aqlmkgchlp mlyigleygl tnnsklaerf fsqalsiape dpfvmhevgv vafqngewkt
      421 aekwfldale kikaignevt vdkwepllnn lghvcrklkk yaealdyhrq alvlipqnas
      481 tysaigyihs lmgnfenavd yfhteqtlkt n
//
LOCUS       XP_047286711             510 aa            linear   PRI 05-AUG-2025
DEFINITION  cell division cycle protein 16 homolog isoform X7 [Homo sapiens].
ACCESSION   XP_047286711
VERSION     XP_047286711.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430755.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..510
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..510
                     /product="cell division cycle protein 16 homolog isoform
                     X7"
                     /calculated_mol_wt=58908
     Region          15..93
                     /region_name="ANAPC3"
                     /note="Anaphase-promoting complex, cyclosome, subunit 3;
                     pfam12895"
                     /db_xref="CDD:463743"
     Region          36..64
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          69..93
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          <133..>501
                     /region_name="PEP_TPR_lipo"
                     /note="putative PEP-CTERM system TPR-repeat lipoprotein;
                     TIGR02917"
                     /db_xref="CDD:274350"
     Region          297..328
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          328..>505
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          335..361
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          366..396
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          401..429
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(402,405..406,409..410,412,436,448..449,452..453,
                     455..456,479,482..483,486..487,490)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          434..473
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          478..502
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..510
                     /gene="CDC16"
                     /gene_synonym="ANAPC6; APC6; CDC16Hs; CUT9"
                     /coded_by="XM_047430755.1:189..1721"
                     /db_xref="GeneID:8881"
                     /db_xref="HGNC:HGNC:1720"
                     /db_xref="MIM:603461"
ORIGIN      
        1 mnlerlrkrv rqyldqqqyq salfwadkva slsrepqdiy wlaqclylta qyhraahalr
       61 srkldklyea crylaarchy aakehqqald vldmeepink rlfekylkde sgfkdpssdw
      121 emsqssikss icllrgkiyd aldnrtlaty sykealkldv ycfeafdllt shhmltaqee
      181 kelleslpls klcneeqell rflfenklkk ynkpsetvip esvdglqenl dvvvslaerh
      241 yyncdfkmcy kltsvvmekd pfhasclpvh igtlvelnka nelfylshkl vdlypsnpvs
      301 wfavgcyylm vghkneharr ylskattlek tygpawiayg hsfavesehd qamaayftaa
      361 qlmkgchlpm lyigleyglt nnsklaerff sqalsiaped pfvmhevgvv afqngewkta
      421 ekwfldalek ikaignevtv dkwepllnnl ghvcrklkky aealdyhrqa lvlipqnast
      481 ysaigyihsl mgnfenavdy fhteqtlktn
//
LOCUS       XP_047286712             459 aa            linear   PRI 05-AUG-2025
DEFINITION  cell division cycle protein 16 homolog isoform X8 [Homo sapiens].
ACCESSION   XP_047286712
VERSION     XP_047286712.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430756.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..459
                     /product="cell division cycle protein 16 homolog isoform
                     X8"
                     /calculated_mol_wt=53241
     Region          15..93
                     /region_name="ANAPC3"
                     /note="Anaphase-promoting complex, cyclosome, subunit 3;
                     pfam12895"
                     /db_xref="CDD:463743"
     Region          36..64
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          69..93
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          291..>454
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          297..328
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          333..361
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          395..421
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          426..451
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..459
                     /gene="CDC16"
                     /gene_synonym="ANAPC6; APC6; CDC16Hs; CUT9"
                     /coded_by="XM_047430756.1:189..1568"
                     /db_xref="GeneID:8881"
                     /db_xref="HGNC:HGNC:1720"
                     /db_xref="MIM:603461"
ORIGIN      
        1 mnlerlrkrv rqyldqqqyq salfwadkva slsrepqdiy wlaqclylta qyhraahalr
       61 srkldklyea crylaarchy aakehqqald vldmeepink rlfekylkde sgfkdpssdw
      121 emsqssikss icllrgkiyd aldnrtlaty sykealkldv ycfeafdllt shhmltaqee
      181 kelleslpls klcneeqell rflfenklkk ynkpsetvip esvdglqenl dvvvslaerh
      241 yyncdfkmcy kltsvvmekd pfhasclpvh igtlvelnka nelfylshkl vdlypsnpvs
      301 wfavgcyylm vghkneharr ylskattlek tygpawiayg hsfavesehd qamaayftaa
      361 qlmkgwktae kwfldaleki kaignevtvd kwepllnnlg hvcrklkkya ealdyhrqal
      421 vlipqnasty saigyihslm gnfenavdyf hteqtlktn
//
LOCUS       XP_047286713             441 aa            linear   PRI 05-AUG-2025
DEFINITION  cell division cycle protein 16 homolog isoform X9 [Homo sapiens].
ACCESSION   XP_047286713
VERSION     XP_047286713.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430757.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..441
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..441
                     /product="cell division cycle protein 16 homolog isoform
                     X9"
                     /calculated_mol_wt=50992
     Region          15..94
                     /region_name="ANAPC3"
                     /note="Anaphase-promoting complex, cyclosome, subunit 3;
                     pfam12895"
                     /db_xref="CDD:463743"
     Region          36..65
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          70..94
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          <134..>429
                     /region_name="PEP_TPR_lipo"
                     /note="putative PEP-CTERM system TPR-repeat lipoprotein;
                     TIGR02917"
                     /db_xref="CDD:274350"
     Region          292..>430
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          298..329
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          336..362
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(338..339,342..343,345,369,372..373,376..377,
                     379..380,403,406..407,410..411,414)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          367..397
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          402..430
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..441
                     /gene="CDC16"
                     /gene_synonym="ANAPC6; APC6; CDC16Hs; CUT9"
                     /coded_by="XM_047430757.1:189..1514"
                     /db_xref="GeneID:8881"
                     /db_xref="HGNC:HGNC:1720"
                     /db_xref="MIM:603461"
ORIGIN      
        1 mnlerlrkrv rqyldqqqyq salfwadkva slsreepqdi ywlaqclylt aqyhraahal
       61 rsrkldklye acrylaarch yaakehqqal dvldmeepin krlfekylkd esgfkdpssd
      121 wemsqssiks sicllrgkiy daldnrtlat ysykealkld vycfeafdll tshhmltaqe
      181 ekelleslpl sklcneeqel lrflfenklk kynkpsetvi pesvdglqen ldvvvslaer
      241 hyyncdfkmc ykltsvvmek dpfhasclpv higtlvelnk anelfylshk lvdlypsnpv
      301 swfavgcyyl mvghknehar rylskattle ktygpawiay ghsfaveseh dqamaayfta
      361 aqlmkgchlp mlyigleygl tnnsklaerf fsqalsiape dpfvmhevgv vafqngewkt
      421 aekwfldale kikaignekv c
//
LOCUS       XP_047286714             390 aa            linear   PRI 05-AUG-2025
DEFINITION  cell division cycle protein 16 homolog isoform X10 [Homo sapiens].
ACCESSION   XP_047286714
VERSION     XP_047286714.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430758.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..390
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..390
                     /product="cell division cycle protein 16 homolog isoform
                     X10"
                     /calculated_mol_wt=45325
     Region          15..94
                     /region_name="ANAPC3"
                     /note="Anaphase-promoting complex, cyclosome, subunit 3;
                     pfam12895"
                     /db_xref="CDD:463743"
     Region          36..65
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          70..94
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          275..>363
                     /region_name="Spy"
                     /note="Predicted O-linked N-acetylglucosamine transferase,
                     SPINDLY family [Posttranslational modification, protein
                     turnover, chaperones]; COG3914"
                     /db_xref="CDD:443119"
     Region          298..329
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          334..362
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..390
                     /gene="CDC16"
                     /gene_synonym="ANAPC6; APC6; CDC16Hs; CUT9"
                     /coded_by="XM_047430758.1:189..1361"
                     /db_xref="GeneID:8881"
                     /db_xref="HGNC:HGNC:1720"
                     /db_xref="MIM:603461"
ORIGIN      
        1 mnlerlrkrv rqyldqqqyq salfwadkva slsreepqdi ywlaqclylt aqyhraahal
       61 rsrkldklye acrylaarch yaakehqqal dvldmeepin krlfekylkd esgfkdpssd
      121 wemsqssiks sicllrgkiy daldnrtlat ysykealkld vycfeafdll tshhmltaqe
      181 ekelleslpl sklcneeqel lrflfenklk kynkpsetvi pesvdglqen ldvvvslaer
      241 hyyncdfkmc ykltsvvmek dpfhasclpv higtlvelnk anelfylshk lvdlypsnpv
      301 swfavgcyyl mvghknehar rylskattle ktygpawiay ghsfaveseh dqamaayfta
      361 aqlmkgwkta ekwfldalek ikaignekvc
//
LOCUS       XP_011533598             421 aa            linear   PRI 05-AUG-2025
DEFINITION  cyclin-A1 isoform X1 [Homo sapiens].
ACCESSION   XP_011533598
VERSION     XP_011533598.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535296.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..421
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..421
                     /product="cyclin-A1 isoform X1"
                     /calculated_mol_wt=47363
     Region          88..146
                     /region_name="Cyclin_N2"
                     /note="Cyclin-A N-terminal APC/C binding region;
                     pfam16500"
                     /db_xref="CDD:465146"
     Region          132..294
                     /region_name="CYCLIN_CCNA1_rpt1"
                     /note="first cyclin box found in cyclin-A1 (CCNA1);
                     cd20560"
                     /db_xref="CDD:410263"
     Site            order(164,166..168,170..171,174,217,252,255..259,263..264,
                     277..278,281,284..285,288..289,292..294)
                     /site_type="other"
                     /note="putative CDK interface [polypeptide binding]"
                     /db_xref="CDD:410263"
     Region          298..420
                     /region_name="CYCLIN_CCNA1_rpt2"
                     /note="second cyclin box found in cyclin-A1 (CCNA1) and
                     similar proteins; cd20563"
                     /db_xref="CDD:410266"
     Site            order(301..302,305)
                     /site_type="other"
                     /note="putative CDK interface [polypeptide binding]"
                     /db_xref="CDD:410266"
     CDS             1..421
                     /gene="CCNA1"
                     /gene_synonym="CT146"
                     /coded_by="XM_011535296.3:83..1348"
                     /db_xref="GeneID:8900"
                     /db_xref="HGNC:HGNC:1577"
                     /db_xref="MIM:604036"
ORIGIN      
        1 mhcsnpksgv vlatvargpd acqiltrapl gqdppqrtvl glltangqyr rtcgqgitri
       61 rcysgsenaf ppagkkalpd cgvqeppkqg fdiymdeleq gdrdscsvre gmafedvyev
      121 dtgtlksdlh flldfntvsp mlvdssllsq sedisslgtd vinvteyaee iyqylreaei
      181 rhrpkahymk kqpditegmr tilvdwlvev geeyklraet lylavnfldr flscmsvlrg
      241 klqlvgtaam llaskyeeiy ppevdefvyi tddtytkrql lkmehlllkv lafdltvptt
      301 nqfllqylrr qgvcvrtenl akyvaelsll eadpflkylp sliaaaafcl anytvnkhfw
      361 petlaaftgy slseivpcls elhkayldip hrpqqairek ykaskylcvs lmeppavlll
      421 q
//
LOCUS       XP_011533596             421 aa            linear   PRI 05-AUG-2025
DEFINITION  cyclin-A1 isoform X1 [Homo sapiens].
ACCESSION   XP_011533596
VERSION     XP_011533596.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535294.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..421
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..421
                     /product="cyclin-A1 isoform X1"
                     /calculated_mol_wt=47363
     Region          88..146
                     /region_name="Cyclin_N2"
                     /note="Cyclin-A N-terminal APC/C binding region;
                     pfam16500"
                     /db_xref="CDD:465146"
     Region          132..294
                     /region_name="CYCLIN_CCNA1_rpt1"
                     /note="first cyclin box found in cyclin-A1 (CCNA1);
                     cd20560"
                     /db_xref="CDD:410263"
     Site            order(164,166..168,170..171,174,217,252,255..259,263..264,
                     277..278,281,284..285,288..289,292..294)
                     /site_type="other"
                     /note="putative CDK interface [polypeptide binding]"
                     /db_xref="CDD:410263"
     Region          298..420
                     /region_name="CYCLIN_CCNA1_rpt2"
                     /note="second cyclin box found in cyclin-A1 (CCNA1) and
                     similar proteins; cd20563"
                     /db_xref="CDD:410266"
     Site            order(301..302,305)
                     /site_type="other"
                     /note="putative CDK interface [polypeptide binding]"
                     /db_xref="CDD:410266"
     CDS             1..421
                     /gene="CCNA1"
                     /gene_synonym="CT146"
                     /coded_by="XM_011535294.3:285..1550"
                     /db_xref="GeneID:8900"
                     /db_xref="HGNC:HGNC:1577"
                     /db_xref="MIM:604036"
ORIGIN      
        1 mhcsnpksgv vlatvargpd acqiltrapl gqdppqrtvl glltangqyr rtcgqgitri
       61 rcysgsenaf ppagkkalpd cgvqeppkqg fdiymdeleq gdrdscsvre gmafedvyev
      121 dtgtlksdlh flldfntvsp mlvdssllsq sedisslgtd vinvteyaee iyqylreaei
      181 rhrpkahymk kqpditegmr tilvdwlvev geeyklraet lylavnfldr flscmsvlrg
      241 klqlvgtaam llaskyeeiy ppevdefvyi tddtytkrql lkmehlllkv lafdltvptt
      301 nqfllqylrr qgvcvrtenl akyvaelsll eadpflkylp sliaaaafcl anytvnkhfw
      361 petlaaftgy slseivpcls elhkayldip hrpqqairek ykaskylcvs lmeppavlll
      421 q
//
LOCUS       XP_011533597             421 aa            linear   PRI 05-AUG-2025
DEFINITION  cyclin-A1 isoform X1 [Homo sapiens].
ACCESSION   XP_011533597
VERSION     XP_011533597.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535295.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..421
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..421
                     /product="cyclin-A1 isoform X1"
                     /calculated_mol_wt=47363
     Region          88..146
                     /region_name="Cyclin_N2"
                     /note="Cyclin-A N-terminal APC/C binding region;
                     pfam16500"
                     /db_xref="CDD:465146"
     Region          132..294
                     /region_name="CYCLIN_CCNA1_rpt1"
                     /note="first cyclin box found in cyclin-A1 (CCNA1);
                     cd20560"
                     /db_xref="CDD:410263"
     Site            order(164,166..168,170..171,174,217,252,255..259,263..264,
                     277..278,281,284..285,288..289,292..294)
                     /site_type="other"
                     /note="putative CDK interface [polypeptide binding]"
                     /db_xref="CDD:410263"
     Region          298..420
                     /region_name="CYCLIN_CCNA1_rpt2"
                     /note="second cyclin box found in cyclin-A1 (CCNA1) and
                     similar proteins; cd20563"
                     /db_xref="CDD:410266"
     Site            order(301..302,305)
                     /site_type="other"
                     /note="putative CDK interface [polypeptide binding]"
                     /db_xref="CDD:410266"
     CDS             1..421
                     /gene="CCNA1"
                     /gene_synonym="CT146"
                     /coded_by="XM_011535295.3:282..1547"
                     /db_xref="GeneID:8900"
                     /db_xref="HGNC:HGNC:1577"
                     /db_xref="MIM:604036"
ORIGIN      
        1 mhcsnpksgv vlatvargpd acqiltrapl gqdppqrtvl glltangqyr rtcgqgitri
       61 rcysgsenaf ppagkkalpd cgvqeppkqg fdiymdeleq gdrdscsvre gmafedvyev
      121 dtgtlksdlh flldfntvsp mlvdssllsq sedisslgtd vinvteyaee iyqylreaei
      181 rhrpkahymk kqpditegmr tilvdwlvev geeyklraet lylavnfldr flscmsvlrg
      241 klqlvgtaam llaskyeeiy ppevdefvyi tddtytkrql lkmehlllkv lafdltvptt
      301 nqfllqylrr qgvcvrtenl akyvaelsll eadpflkylp sliaaaafcl anytvnkhfw
      361 petlaaftgy slseivpcls elhkayldip hrpqqairek ykaskylcvs lmeppavlll
      421 q
//
LOCUS       XP_047286715            1123 aa            linear   PRI 05-AUG-2025
DEFINITION  stAR-related lipid transfer protein 13 isoform X1 [Homo sapiens].
ACCESSION   XP_047286715
VERSION     XP_047286715.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430759.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1123
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1123
                     /product="stAR-related lipid transfer protein 13 isoform
                     X1"
                     /calculated_mol_wt=125569
     Region          67..130
                     /region_name="SAM_DLC2"
                     /note="SAM domain of STARD13-like subfamily; cd09592"
                     /db_xref="CDD:188991"
     Site            order(81,84,86)
                     /site_type="lipid-binding"
                     /note="lipid binding site [chemical binding]"
                     /db_xref="CDD:188991"
     Region          667..884
                     /region_name="RhoGAP_DLC1"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain of DLC1-like proteins. DLC1 shows in
                     vitro GAP activity towards RhoA and CDC42. Beside its
                     C-terminal GAP domain, DLC1 also contains a SAM (sterile
                     alpha motif) and a START...; cd04375"
                     /db_xref="CDD:239840"
     Site            order(709,746,750,819,822..823,864)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239840"
     Site            709
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239840"
     Region          910..1114
                     /region_name="START_STARD13-like"
                     /note="C-terminal lipid-binding START domain of mammalian
                     STARD13 and related proteins, which also have an
                     N-terminal Rho GTPase-activating protein (RhoGAP) domain;
                     cd08909"
                     /db_xref="CDD:176918"
     Site            order(941..942,950,963,965,976,980,984,987..988,990..991,
                     1009,1011..1014,1017,1020,1022,1024,1041,1057,1059..1062,
                     1064,1076,1078,1080,1082,1084,1086,1093,1095..1097,
                     1099..1101,1103..1104,1107)
                     /site_type="other"
                     /note="putative lipid binding site [chemical binding]"
                     /db_xref="CDD:176918"
     CDS             1..1123
                     /gene="STARD13"
                     /gene_synonym="ARHGAP37; DLC2; GT650; LINC00464"
                     /coded_by="XM_047430759.1:1271..4642"
                     /db_xref="GeneID:90627"
                     /db_xref="HGNC:HGNC:19164"
                     /db_xref="MIM:609866"
ORIGIN      
        1 mpsdeprktk dsinlesnpk knhqkkgicr tktaniqnld gvpsqmstgt qpktkvlsdn
       61 rpkerveiea keacdwlraa gfpqyaqlye dsqfpiniva vkndhdflek dlveplcrrl
      121 ntlnkcasmk ldvnfqrkkg ddsdeedlci snkwtfqrts rrwsrvddly tllprgdrng
      181 spggtgmrnt tssesvltdl sepevcsihs essggsdsrs qpgqcctdnp vmldaplvss
      241 slpqpprdvl nhpfhpknek ptraraksfl krmetlrgkg ahgrhkgsgr tgglvisgpm
      301 lqqepesfka mqciqipngd lqnspppacr kglpcsgkss gesspsehss sgvstpclke
      361 rkcheankrg gmyledldvl agtalpdagd qsrmhefhsq enlvvhipkd hkpgtfpkal
      421 sieslsptds sngvnwrtgs islgreqvpg areprlmasc hrasrvsiyd nvpgshlyas
      481 tgdlldlekd dlfphlddil qhvnglqevv ddwskdvlpe lqthdtlvge pglstfpspn
      541 qitldfegns vsegrttpsd verdvtslne seppgvrdrr dsgvgasltr pnrrlrwnsf
      601 qlshqprpap asphissqta sqlsllqrfs llrltaimek hsmsnkhgwt wsvpkfmkrm
      661 kvpdykdkav fgvplivhvq rtgqplpqsi qqalrylrsn cldqvglfrk sgvksrihal
      721 rqmnenfpen vnyedqsayd vadmvkqffr dlpeplftnk lsetflhiyq yvskeqrlqa
      781 vqaailllad enrevlqtll cflndvvnlv eenqmtpmnl avclapslfh lnllkkessp
      841 rviqkkyatg kpdqkdlnen laaaqglahm imecdrlfev phelvaqsrn syveaeihvp
      901 tleelgtqle esgatfhtyl nhliqglqke akekfkgwvt csstdntdla fkkvgdgnpl
      961 klwkasveve appsvvlnrv lrerhlwded fvqwkvvetl drqteiyqyv lnsmaphpsr
     1021 dfvvlrtwkt dlpkgmctlv slsveheeaq llggvravvm dsqyliepcg sgksrlthic
     1081 ridlkghspe wyskgfghlc aaevarirns fqpliaegpe tki
//
LOCUS       XP_024305197            1078 aa            linear   PRI 05-AUG-2025
DEFINITION  stAR-related lipid transfer protein 13 isoform X2 [Homo sapiens].
ACCESSION   XP_024305197
VERSION     XP_024305197.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449429.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1078
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1078
                     /product="stAR-related lipid transfer protein 13 isoform
                     X2"
                     /calculated_mol_wt=120539
     Region          22..85
                     /region_name="SAM_DLC2"
                     /note="SAM domain of STARD13-like subfamily; cd09592"
                     /db_xref="CDD:188991"
     Site            order(36,39,41)
                     /site_type="lipid-binding"
                     /note="lipid binding site [chemical binding]"
                     /db_xref="CDD:188991"
     Region          622..839
                     /region_name="RhoGAP_DLC1"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain of DLC1-like proteins. DLC1 shows in
                     vitro GAP activity towards RhoA and CDC42. Beside its
                     C-terminal GAP domain, DLC1 also contains a SAM (sterile
                     alpha motif) and a START...; cd04375"
                     /db_xref="CDD:239840"
     Site            order(664,701,705,774,777..778,819)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239840"
     Site            664
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239840"
     Region          865..1069
                     /region_name="START_STARD13-like"
                     /note="C-terminal lipid-binding START domain of mammalian
                     STARD13 and related proteins, which also have an
                     N-terminal Rho GTPase-activating protein (RhoGAP) domain;
                     cd08909"
                     /db_xref="CDD:176918"
     Site            order(896..897,905,918,920,931,935,939,942..943,945..946,
                     964,966..969,972,975,977,979,996,1012,1014..1017,1019,
                     1031,1033,1035,1037,1039,1041,1048,1050..1052,1054..1056,
                     1058..1059,1062)
                     /site_type="other"
                     /note="putative lipid binding site [chemical binding]"
                     /db_xref="CDD:176918"
     CDS             1..1078
                     /gene="STARD13"
                     /gene_synonym="ARHGAP37; DLC2; GT650; LINC00464"
                     /coded_by="XM_024449429.2:12167..15403"
                     /db_xref="GeneID:90627"
                     /db_xref="HGNC:HGNC:19164"
                     /db_xref="MIM:609866"
ORIGIN      
        1 mstgtqpktk vlsdnrpker veieakeacd wlraagfpqy aqlyedsqfp inivavkndh
       61 dflekdlvep lcrrlntlnk casmkldvnf qrkkgddsde edlcisnkwt fqrtsrrwsr
      121 vddlytllpr gdrngspggt gmrnttsses vltdlsepev csihsessgg sdsrsqpgqc
      181 ctdnpvmlda plvssslpqp prdvlnhpfh pknekptrar aksflkrmet lrgkgahgrh
      241 kgsgrtgglv isgpmlqqep esfkamqciq ipngdlqnsp ppacrkglpc sgkssgessp
      301 sehsssgvst pclkerkche ankrggmyle dldvlagtal pdagdqsrmh efhsqenlvv
      361 hipkdhkpgt fpkalsiesl sptdssngvn wrtgsislgr eqvpgarepr lmaschrasr
      421 vsiydnvpgs hlyastgdll dlekddlfph lddilqhvng lqevvddwsk dvlpelqthd
      481 tlvgepglst fpspnqitld fegnsvsegr ttpsdverdv tslneseppg vrdrrdsgvg
      541 asltrpnrrl rwnsfqlshq prpapasphi ssqtasqlsl lqrfsllrlt aimekhsmsn
      601 khgwtwsvpk fmkrmkvpdy kdkavfgvpl ivhvqrtgqp lpqsiqqalr ylrsncldqv
      661 glfrksgvks rihalrqmne nfpenvnyed qsaydvadmv kqffrdlpep lftnklsetf
      721 lhiyqyvske qrlqavqaai llladenrev lqtllcflnd vvnlveenqm tpmnlavcla
      781 pslfhlnllk kessprviqk kyatgkpdqk dlnenlaaaq glahmimecd rlfevphelv
      841 aqsrnsyvea eihvptleel gtqleesgat fhtylnhliq glqkeakekf kgwvtcsstd
      901 ntdlafkkvg dgnplklwka sveveappsv vlnrvlrerh lwdedfvqwk vvetldrqte
      961 iyqyvlnsma phpsrdfvvl rtwktdlpkg mctlvslsve heeaqllggv ravvmdsqyl
     1021 iepcgsgksr lthicridlk ghspewyskg fghlcaaeva rirnsfqpli aegpetki
//
LOCUS       XP_016876324            1078 aa            linear   PRI 05-AUG-2025
DEFINITION  stAR-related lipid transfer protein 13 isoform X2 [Homo sapiens].
ACCESSION   XP_016876324
VERSION     XP_016876324.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020835.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1078
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1078
                     /product="stAR-related lipid transfer protein 13 isoform
                     X2"
                     /calculated_mol_wt=120539
     Region          22..85
                     /region_name="SAM_DLC2"
                     /note="SAM domain of STARD13-like subfamily; cd09592"
                     /db_xref="CDD:188991"
     Site            order(36,39,41)
                     /site_type="lipid-binding"
                     /note="lipid binding site [chemical binding]"
                     /db_xref="CDD:188991"
     Region          622..839
                     /region_name="RhoGAP_DLC1"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain of DLC1-like proteins. DLC1 shows in
                     vitro GAP activity towards RhoA and CDC42. Beside its
                     C-terminal GAP domain, DLC1 also contains a SAM (sterile
                     alpha motif) and a START...; cd04375"
                     /db_xref="CDD:239840"
     Site            order(664,701,705,774,777..778,819)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239840"
     Site            664
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239840"
     Region          865..1069
                     /region_name="START_STARD13-like"
                     /note="C-terminal lipid-binding START domain of mammalian
                     STARD13 and related proteins, which also have an
                     N-terminal Rho GTPase-activating protein (RhoGAP) domain;
                     cd08909"
                     /db_xref="CDD:176918"
     Site            order(896..897,905,918,920,931,935,939,942..943,945..946,
                     964,966..969,972,975,977,979,996,1012,1014..1017,1019,
                     1031,1033,1035,1037,1039,1041,1048,1050..1052,1054..1056,
                     1058..1059,1062)
                     /site_type="other"
                     /note="putative lipid binding site [chemical binding]"
                     /db_xref="CDD:176918"
     CDS             1..1078
                     /gene="STARD13"
                     /gene_synonym="ARHGAP37; DLC2; GT650; LINC00464"
                     /coded_by="XM_017020835.3:223..3459"
                     /db_xref="GeneID:90627"
                     /db_xref="HGNC:HGNC:19164"
                     /db_xref="MIM:609866"
ORIGIN      
        1 mstgtqpktk vlsdnrpker veieakeacd wlraagfpqy aqlyedsqfp inivavkndh
       61 dflekdlvep lcrrlntlnk casmkldvnf qrkkgddsde edlcisnkwt fqrtsrrwsr
      121 vddlytllpr gdrngspggt gmrnttsses vltdlsepev csihsessgg sdsrsqpgqc
      181 ctdnpvmlda plvssslpqp prdvlnhpfh pknekptrar aksflkrmet lrgkgahgrh
      241 kgsgrtgglv isgpmlqqep esfkamqciq ipngdlqnsp ppacrkglpc sgkssgessp
      301 sehsssgvst pclkerkche ankrggmyle dldvlagtal pdagdqsrmh efhsqenlvv
      361 hipkdhkpgt fpkalsiesl sptdssngvn wrtgsislgr eqvpgarepr lmaschrasr
      421 vsiydnvpgs hlyastgdll dlekddlfph lddilqhvng lqevvddwsk dvlpelqthd
      481 tlvgepglst fpspnqitld fegnsvsegr ttpsdverdv tslneseppg vrdrrdsgvg
      541 asltrpnrrl rwnsfqlshq prpapasphi ssqtasqlsl lqrfsllrlt aimekhsmsn
      601 khgwtwsvpk fmkrmkvpdy kdkavfgvpl ivhvqrtgqp lpqsiqqalr ylrsncldqv
      661 glfrksgvks rihalrqmne nfpenvnyed qsaydvadmv kqffrdlpep lftnklsetf
      721 lhiyqyvske qrlqavqaai llladenrev lqtllcflnd vvnlveenqm tpmnlavcla
      781 pslfhlnllk kessprviqk kyatgkpdqk dlnenlaaaq glahmimecd rlfevphelv
      841 aqsrnsyvea eihvptleel gtqleesgat fhtylnhliq glqkeakekf kgwvtcsstd
      901 ntdlafkkvg dgnplklwka sveveappsv vlnrvlrerh lwdedfvqwk vvetldrqte
      961 iyqyvlnsma phpsrdfvvl rtwktdlpkg mctlvslsve heeaqllggv ravvmdsqyl
     1021 iepcgsgksr lthicridlk ghspewyskg fghlcaaeva rirnsfqpli aegpetki
//
LOCUS       XP_047286716            1078 aa            linear   PRI 05-AUG-2025
DEFINITION  stAR-related lipid transfer protein 13 isoform X2 [Homo sapiens].
ACCESSION   XP_047286716
VERSION     XP_047286716.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430760.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1078
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1078
                     /product="stAR-related lipid transfer protein 13 isoform
                     X2"
                     /calculated_mol_wt=120539
     Region          22..85
                     /region_name="SAM_DLC2"
                     /note="SAM domain of STARD13-like subfamily; cd09592"
                     /db_xref="CDD:188991"
     Site            order(36,39,41)
                     /site_type="lipid-binding"
                     /note="lipid binding site [chemical binding]"
                     /db_xref="CDD:188991"
     Region          622..839
                     /region_name="RhoGAP_DLC1"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain of DLC1-like proteins. DLC1 shows in
                     vitro GAP activity towards RhoA and CDC42. Beside its
                     C-terminal GAP domain, DLC1 also contains a SAM (sterile
                     alpha motif) and a START...; cd04375"
                     /db_xref="CDD:239840"
     Site            order(664,701,705,774,777..778,819)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239840"
     Site            664
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239840"
     Region          865..1069
                     /region_name="START_STARD13-like"
                     /note="C-terminal lipid-binding START domain of mammalian
                     STARD13 and related proteins, which also have an
                     N-terminal Rho GTPase-activating protein (RhoGAP) domain;
                     cd08909"
                     /db_xref="CDD:176918"
     Site            order(896..897,905,918,920,931,935,939,942..943,945..946,
                     964,966..969,972,975,977,979,996,1012,1014..1017,1019,
                     1031,1033,1035,1037,1039,1041,1048,1050..1052,1054..1056,
                     1058..1059,1062)
                     /site_type="other"
                     /note="putative lipid binding site [chemical binding]"
                     /db_xref="CDD:176918"
     CDS             1..1078
                     /gene="STARD13"
                     /gene_synonym="ARHGAP37; DLC2; GT650; LINC00464"
                     /coded_by="XM_047430760.1:9810..13046"
                     /db_xref="GeneID:90627"
                     /db_xref="HGNC:HGNC:19164"
                     /db_xref="MIM:609866"
ORIGIN      
        1 mstgtqpktk vlsdnrpker veieakeacd wlraagfpqy aqlyedsqfp inivavkndh
       61 dflekdlvep lcrrlntlnk casmkldvnf qrkkgddsde edlcisnkwt fqrtsrrwsr
      121 vddlytllpr gdrngspggt gmrnttsses vltdlsepev csihsessgg sdsrsqpgqc
      181 ctdnpvmlda plvssslpqp prdvlnhpfh pknekptrar aksflkrmet lrgkgahgrh
      241 kgsgrtgglv isgpmlqqep esfkamqciq ipngdlqnsp ppacrkglpc sgkssgessp
      301 sehsssgvst pclkerkche ankrggmyle dldvlagtal pdagdqsrmh efhsqenlvv
      361 hipkdhkpgt fpkalsiesl sptdssngvn wrtgsislgr eqvpgarepr lmaschrasr
      421 vsiydnvpgs hlyastgdll dlekddlfph lddilqhvng lqevvddwsk dvlpelqthd
      481 tlvgepglst fpspnqitld fegnsvsegr ttpsdverdv tslneseppg vrdrrdsgvg
      541 asltrpnrrl rwnsfqlshq prpapasphi ssqtasqlsl lqrfsllrlt aimekhsmsn
      601 khgwtwsvpk fmkrmkvpdy kdkavfgvpl ivhvqrtgqp lpqsiqqalr ylrsncldqv
      661 glfrksgvks rihalrqmne nfpenvnyed qsaydvadmv kqffrdlpep lftnklsetf
      721 lhiyqyvske qrlqavqaai llladenrev lqtllcflnd vvnlveenqm tpmnlavcla
      781 pslfhlnllk kessprviqk kyatgkpdqk dlnenlaaaq glahmimecd rlfevphelv
      841 aqsrnsyvea eihvptleel gtqleesgat fhtylnhliq glqkeakekf kgwvtcsstd
      901 ntdlafkkvg dgnplklwka sveveappsv vlnrvlrerh lwdedfvqwk vvetldrqte
      961 iyqyvlnsma phpsrdfvvl rtwktdlpkg mctlvslsve heeaqllggv ravvmdsqyl
     1021 iepcgsgksr lthicridlk ghspewyskg fghlcaaeva rirnsfqpli aegpetki
//
LOCUS       XP_047286717             334 aa            linear   PRI 05-AUG-2025
DEFINITION  NEDD4-binding protein 2-like 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047286717
VERSION     XP_047286717.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430761.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 14% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..334
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..334
                     /product="NEDD4-binding protein 2-like 1 isoform X1"
                     /calculated_mol_wt=39426
     Region          164..268
                     /region_name="AAA_33"
                     /note="AAA domain; pfam13671"
                     /db_xref="CDD:463952"
     CDS             1..334
                     /gene="N4BP2L1"
                     /gene_synonym="CG018"
                     /coded_by="XM_047430761.1:3925..4929"
                     /db_xref="GeneID:90634"
                     /db_xref="HGNC:HGNC:25037"
                     /db_xref="MIM:621053"
ORIGIN      
        1 mplhfslgdr arlrleggga gnkkkrvrii rlkerriqep lihsqifteh lpcawhssrc
       61 sewssgqrrq kslpswnmys irekkfsrkk gnfsicsalf sqkiskgfhr yatggiypqe
      121 mstytqecsr ylgiiseqnk dpalvdlmcq rqlqhdfpra lifstddfff redgayefnp
      181 dfleeahewn qkrarkamrn gispiiidnt nlhawemkpy avmalennye vifrepdtrw
      241 kfnvqelarr nihgvsreki hrmkeryehd vtfhsvlhae kpsrmnrnqd rnnalpsnna
      301 rywnsytefp nrrahggftn essyhrrggc hhgy
//
LOCUS       XP_047286718             279 aa            linear   PRI 05-AUG-2025
DEFINITION  NEDD4-binding protein 2-like 1 isoform X2 [Homo sapiens].
ACCESSION   XP_047286718
VERSION     XP_047286718.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430762.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 17% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..279
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..279
                     /product="NEDD4-binding protein 2-like 1 isoform X2"
                     /calculated_mol_wt=32838
     Region          164..250
                     /region_name="AAA_33"
                     /note="AAA domain; pfam13671"
                     /db_xref="CDD:463952"
     CDS             1..279
                     /gene="N4BP2L1"
                     /gene_synonym="CG018"
                     /coded_by="XM_047430762.1:3925..4764"
                     /db_xref="GeneID:90634"
                     /db_xref="HGNC:HGNC:25037"
                     /db_xref="MIM:621053"
ORIGIN      
        1 mplhfslgdr arlrleggga gnkkkrvrii rlkerriqep lihsqifteh lpcawhssrc
       61 sewssgqrrq kslpswnmys irekkfsrkk gnfsicsalf sqkiskgfhr yatggiypqe
      121 mstytqecsr ylgiiseqnk dpalvdlmcq rqlqhdfpra lifstddfff redgayefnp
      181 dfleeahewn qkrarkamrn gispiiidnt nlhawemkpy avmalennye vifrepdtrw
      241 kfnvqelarq ivsskwicgl lhqnclrwll ksefmdpiq
//
LOCUS       XP_047286719             264 aa            linear   PRI 05-AUG-2025
DEFINITION  NEDD4-binding protein 2-like 1 isoform X3 [Homo sapiens].
ACCESSION   XP_047286719
VERSION     XP_047286719.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430763.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..264
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..264
                     /product="NEDD4-binding protein 2-like 1 isoform X3"
                     /calculated_mol_wt=31122
     Region          164..>221
                     /region_name="AAA_33"
                     /note="AAA domain; pfam13671"
                     /db_xref="CDD:463952"
     CDS             1..264
                     /gene="N4BP2L1"
                     /gene_synonym="CG018"
                     /coded_by="XM_047430763.1:3925..4719"
                     /db_xref="GeneID:90634"
                     /db_xref="HGNC:HGNC:25037"
                     /db_xref="MIM:621053"
ORIGIN      
        1 mplhfslgdr arlrleggga gnkkkrvrii rlkerriqep lihsqifteh lpcawhssrc
       61 sewssgqrrq kslpswnmys irekkfsrkk gnfsicsalf sqkiskgfhr yatggiypqe
      121 mstytqecsr ylgiiseqnk dpalvdlmcq rqlqhdfpra lifstddfff redgayefnp
      181 dfleeahewn qkrarkamrn gispiiidnt nlhawemkpy avmvfqteqk nlfrlemdmv
      241 vfrpemkkhs wclkrknppn ertv
//
LOCUS       XP_016876327             257 aa            linear   PRI 05-AUG-2025
DEFINITION  NEDD4-binding protein 2-like 1 isoform X4 [Homo sapiens].
ACCESSION   XP_016876327
VERSION     XP_016876327.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020838.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..257
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..257
                     /product="NEDD4-binding protein 2-like 1 isoform X4"
                     /calculated_mol_wt=30427
     Region          87..191
                     /region_name="AAA_33"
                     /note="AAA domain; pfam13671"
                     /db_xref="CDD:463952"
     CDS             1..257
                     /gene="N4BP2L1"
                     /gene_synonym="CG018"
                     /coded_by="XM_017020838.3:725..1498"
                     /db_xref="GeneID:90634"
                     /db_xref="HGNC:HGNC:25037"
                     /db_xref="MIM:621053"
ORIGIN      
        1 mysirekkfs rkkgnfsics alfsqkiskg fhryatggiy pqemstytqe csrylgiise
       61 qnkdpalvdl mcqrqlqhdf pralifstdd fffredgaye fnpdfleeah ewnqkrarka
      121 mrngispiii dntnlhawem kpyavmalen nyevifrepd trwkfnvqel arrnihgvsr
      181 ekihrmkery ehdvtfhsvl haekpsrmnr nqdrnnalps nnarywnsyt efpnrrahgg
      241 ftnessyhrr ggchhgy
//
LOCUS       XP_011533605             212 aa            linear   PRI 05-AUG-2025
DEFINITION  NEDD4-binding protein 2-like 1 isoform X5 [Homo sapiens].
ACCESSION   XP_011533605
VERSION     XP_011533605.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535303.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..212
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..212
                     /product="NEDD4-binding protein 2-like 1 isoform X5"
                     /calculated_mol_wt=25149
     Region          42..146
                     /region_name="AAA_33"
                     /note="AAA domain; pfam13671"
                     /db_xref="CDD:463952"
     CDS             1..212
                     /gene="N4BP2L1"
                     /gene_synonym="CG018"
                     /coded_by="XM_011535303.3:752..1390"
                     /db_xref="GeneID:90634"
                     /db_xref="HGNC:HGNC:25037"
                     /db_xref="MIM:621053"
ORIGIN      
        1 mvsvdsatfp gdlkefskkp pllrrqqgrq lqhdfprali fstddfffre dgayefnpdf
       61 leeahewnqk rarkamrngi spiiidntnl hawemkpyav malennyevi frepdtrwkf
      121 nvqelarrni hgvsrekihr mkeryehdvt fhsvlhaekp srmnrnqdrn nalpsnnary
      181 wnsytefpnr rahggftnes syhrrggchh gy
//
LOCUS       XP_047286720             187 aa            linear   PRI 05-AUG-2025
DEFINITION  NEDD4-binding protein 2-like 1 isoform X6 [Homo sapiens].
ACCESSION   XP_047286720
VERSION     XP_047286720.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430764.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..187
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..187
                     /product="NEDD4-binding protein 2-like 1 isoform X6"
                     /calculated_mol_wt=22397
     Region          17..121
                     /region_name="AAA_33"
                     /note="AAA domain; pfam13671"
                     /db_xref="CDD:463952"
     CDS             1..187
                     /gene="N4BP2L1"
                     /gene_synonym="CG018"
                     /coded_by="XM_047430764.1:150..713"
                     /db_xref="GeneID:90634"
                     /db_xref="HGNC:HGNC:25037"
                     /db_xref="MIM:621053"
ORIGIN      
        1 mcqrqlqhdf pralifstdd fffredgaye fnpdfleeah ewnqkrarka mrngispiii
       61 dntnlhawem kpyavmalen nyevifrepd trwkfnvqel arrnihgvsr ekihrmkery
      121 ehdvtfhsvl haekpsrmnr nqdrnnalps nnarywnsyt efpnrrahgg ftnessyhrr
      181 ggchhgy
//
LOCUS       XP_047286721             170 aa            linear   PRI 05-AUG-2025
DEFINITION  claudin-10 isoform X1 [Homo sapiens].
ACCESSION   XP_047286721
VERSION     XP_047286721.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430765.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..170
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..170
                     /product="claudin-10 isoform X1"
                     /calculated_mol_wt=18450
     Region          <16..121
                     /region_name="PMP22_Claudin"
                     /note="PMP-22/EMP/MP20/Claudin family; cl21598"
                     /db_xref="CDD:473919"
     CDS             1..170
                     /gene="CLDN10"
                     /gene_synonym="CPETRL3; HELIX; OSP-L; OSPL"
                     /coded_by="XM_047430765.1:3286..3798"
                     /db_xref="GeneID:9071"
                     /db_xref="HGNC:HGNC:2033"
                     /db_xref="MIM:617579"
ORIGIN      
        1 mrkinklwll fmlekgyiqa crglmiaavs lgffgsifal fgmkctkvgg sdkakakiac
       61 lagivfilsg lcsmtgcsly ankitteffd plfveqkyel gaalfigwag aslciiggvi
      121 fcfsisdnnk tprytyngat svmssrtkyh ggedfkttnp skqfdknayv
//
LOCUS       XP_011533609             573 aa            linear   PRI 05-AUG-2025
DEFINITION  phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6 isoform
            X1 [Homo sapiens].
ACCESSION   XP_011533609
VERSION     XP_011533609.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535307.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..573
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..573
                     /product="phosphatidylinositol-3,5-bisphosphate
                     3-phosphatase MTMR6 isoform X1"
                     /calculated_mol_wt=66381
     Region          1..101
                     /region_name="PH-GRAM_MTMR6"
                     /note="Myotubularian (MTM) related (MTMR) 6 protein
                     Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase
                     activators and Myotubularins (PH-GRAM) domain; cd13343"
                     /db_xref="CDD:270151"
     Region          130..469
                     /region_name="PTP_DSP_cys"
                     /note="cys-based protein tyrosine phosphatase and
                     dual-specificity phosphatase superfamily; cl28904"
                     /db_xref="CDD:475123"
     CDS             1..573
                     /gene="MTMR6"
                     /coded_by="XM_011535307.2:242..1963"
                     /db_xref="GeneID:9107"
                     /db_xref="HGNC:HGNC:7453"
                     /db_xref="MIM:603561"
ORIGIN      
        1 mehirttkve qvklldrfst snksltgtly ltathllfid shqketwilh hhiasvekla
       61 lttsgcplvi qcknfrtvhf ivprerdchd iynsllqlsk qakyedlyaf synpkqndse
      121 rlqgwqlidl aeeykrmgvp nshwqlsdan rdykicetyp relyvprias kpiivgsskf
      181 rskgrfpvls yyhqdkeaai crcsqplsgf sarcledehl lqaiskanpv nrymyvmdtr
      241 pkrrmqswwa tqkdigriiv risskiqnde kiresnekkr lnamanraag kgyenednys
      301 nirfqfvgie nihvmrsslq kllevngtkg lsvndfysgl essgwlrhik avmdaaifla
      361 kaitvenasv lvhcsdgwdr tsqvcslgsl lldsyyrtik gfmvliekdw isfghkfser
      421 cgqldgdpke vspvftqfle cvwhlteqfp qafefseafl lqihehihsc qfgnflgncq
      481 kereelklke ktyslwpfll edqkkylnpl ysseshrftv lepntvsfnf kklnnakisk
      541 qmassprncy iqfilnhlts klpcvlksrl cyp
//
LOCUS       XP_016876335             426 aa            linear   PRI 05-AUG-2025
DEFINITION  phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6 isoform
            X2 [Homo sapiens].
ACCESSION   XP_016876335
VERSION     XP_016876335.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020846.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..426
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..426
                     /product="phosphatidylinositol-3,5-bisphosphate
                     3-phosphatase MTMR6 isoform X2"
                     /calculated_mol_wt=49445
     Region          <1..236
                     /region_name="PTP_DSP_cys"
                     /note="cys-based protein tyrosine phosphatase and
                     dual-specificity phosphatase superfamily; cl28904"
                     /db_xref="CDD:475123"
     CDS             1..426
                     /gene="MTMR6"
                     /coded_by="XM_017020846.2:305..1585"
                     /db_xref="GeneID:9107"
                     /db_xref="HGNC:HGNC:7453"
                     /db_xref="MIM:603561"
ORIGIN      
        1 myvmdtrpkr rmqswwatqk digriivris skiqndekir esnekkrlna manraagkgy
       61 enednysnir fqfvgienih vmrsslqkll evngtkglsv ndfysgless gwlrhikavm
      121 daaiflakai tvenasvlvh csdgwdrtsq vcslgsllld syyrtikgfm vliekdwisf
      181 ghkfsercgq ldgdpkevsp vftqflecvw hlteqfpqaf efseafllqi hehihscqfg
      241 nflgncqker eelklkekty slwpflledq kkylnplyss eshrftvlep ntvsfnfkfw
      301 rnmyhqfdrt lhprqsvfni imnmneqnkq lekdikdles kikqrknkqt dgiltkellh
      361 svhpespnlk tslcfkeqtl lpvndalrti egsspadnry seyaeefsks epavvsleyg
      421 varmtc
//
LOCUS       XP_047286722             419 aa            linear   PRI 05-AUG-2025
DEFINITION  phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6 isoform
            X3 [Homo sapiens].
ACCESSION   XP_047286722
VERSION     XP_047286722.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430766.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..419
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..419
                     /product="phosphatidylinositol-3,5-bisphosphate
                     3-phosphatase MTMR6 isoform X3"
                     /calculated_mol_wt=48194
     Region          1..101
                     /region_name="PH-GRAM_MTMR6"
                     /note="Myotubularian (MTM) related (MTMR) 6 protein
                     Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase
                     activators and Myotubularins (PH-GRAM) domain; cd13343"
                     /db_xref="CDD:270151"
     Region          130..413
                     /region_name="PTP_DSP_cys"
                     /note="cys-based protein tyrosine phosphatase and
                     dual-specificity phosphatase superfamily; cl28904"
                     /db_xref="CDD:475123"
     CDS             1..419
                     /gene="MTMR6"
                     /coded_by="XM_047430766.1:242..1501"
                     /db_xref="GeneID:9107"
                     /db_xref="HGNC:HGNC:7453"
                     /db_xref="MIM:603561"
ORIGIN      
        1 mehirttkve qvklldrfst snksltgtly ltathllfid shqketwilh hhiasvekla
       61 lttsgcplvi qcknfrtvhf ivprerdchd iynsllqlsk qakyedlyaf synpkqndse
      121 rlqgwqlidl aeeykrmgvp nshwqlsdan rdykicetyp relyvprias kpiivgsskf
      181 rskgrfpvls yyhqdkeaai crcsqplsgf sarcledehl lqaiskanpv nrymyvmdtr
      241 pkrrmqswwa tqkdigriiv risskiqnde kiresnekkr lnamanraag kgyenednys
      301 nirfqfvgie nihvmrsslq kllevngtkg lsvndfysgl essgwlrhik avmdaaifla
      361 kaitvenasv lvhcsdgwdr tsqvcslgsl lldsyyrtik gfmirlkkle icfysgvgk
//
LOCUS       XP_016876336             708 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase DCLK1 isoform X1 [Homo sapiens].
ACCESSION   XP_016876336
VERSION     XP_016876336.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020847.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..708
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..708
                     /product="serine/threonine-protein kinase DCLK1 isoform
                     X1"
                     /calculated_mol_wt=78350
     Region          55..143
                     /region_name="DCX1_DCLK1"
                     /note="Dublecortin-like domain 1 found in
                     doublecortin-like kinase 1 (DCLK1); cd17140"
                     /db_xref="CDD:340660"
     Site            order(55,66..68,74,79..80,82,90,98..100,102..103,106,133)
                     /site_type="other"
                     /note="putative tubulin binding site [polypeptide
                     binding]"
                     /db_xref="CDD:340660"
     Site            order(70,115)
                     /site_type="other"
                     /note="key conserved lysines"
                     /db_xref="CDD:340660"
     Region          182..265
                     /region_name="DCX2"
                     /note="Dublecortin-like domain 2; cd17069"
                     /db_xref="CDD:340589"
     Site            order(184,195..197,203,208..209,211,219,228..229,232,259)
                     /site_type="other"
                     /note="putative DCX-stabilized microtubules [polypeptide
                     binding]"
                     /db_xref="CDD:340589"
     Site            order(199,240)
                     /site_type="other"
                     /note="key conserved lysines"
                     /db_xref="CDD:340589"
     Region          383..650
                     /region_name="STKc_DCKL1"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     Doublecortin-like kinase 1 (also called Doublecortin-like
                     and CAM kinase-like 1); cd14183"
                     /db_xref="CDD:271085"
     Site            order(396..400,404,417,419,449,465..468,472,474,510..511,
                     513,515..516,518,532..533,536,548..552,554)
                     /site_type="active"
                     /db_xref="CDD:271085"
     Site            order(396..399,404,417,419,449,465..468,472,515..516,518,
                     532..533)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271085"
     Site            order(400,472,474,510..511,513,515,536,548..552,554)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:271085"
     Site            532..552
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:271085"
     CDS             1..708
                     /gene="DCLK1"
                     /gene_synonym="CL1; CLICK1; DCAMKL1; DCDC3A; DCLK"
                     /coded_by="XM_017020847.2:289..2415"
                     /db_xref="GeneID:9201"
                     /db_xref="HGNC:HGNC:2700"
                     /db_xref="MIM:604742"
ORIGIN      
        1 msfgrdmele hfderdkaqr ysrgsrvngl pspthsahcs fyrtrtlqtl ssekkakkvr
       61 fyrngdryfk givyaispdr frsfeallad ltrtlsdnvn lpqgvrtiyt idglkkissl
      121 dqlvegesyv cgsiepfkkl eytknvnpnw svnvkttsas ravsslatak gspsevrenk
      181 dfirpklvti irsgvkprka vrillnkkta hsfeqvltdi tdaikldsgv vkrlytldgk
      241 qvmclqdffg dddifiacgp ekfryqddfl ldesecrvvk stsytkiass srrsttkspg
      301 psrrskspas tssvngtpgs qlstprsgks pspsptspgs lrkqrssqhg gsstslastk
      361 vcssmdendg pgeevseegf qipatitery kvgrtigdgn favvkecver stareyalki
      421 ikkskcrgke hmiqnevsil rrvkhpnivl lieemdvpte lylvmelvkg gdlfdaitst
      481 nkyterdasg mlynlasaik ylhslnivhr dikpenllvy ehqdgskslk lgdfglativ
      541 dgplytvcgt ptyvapeiia etgyglkvdi waagvityil lcgfppfrgs gddqevlfdq
      601 ilmgqvdfps pywdnvsdsa kelitmmllv dvdqrfsavq vlehpwvndd glpenehqls
      661 vagkikkhfn tgpkpnstaa gvsviaapar ppllirrgrf sdedatrm
//
LOCUS       XP_047286723             363 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase DCLK1 isoform X2 [Homo sapiens].
ACCESSION   XP_047286723
VERSION     XP_047286723.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430767.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..363
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..363
                     /product="serine/threonine-protein kinase DCLK1 isoform
                     X2"
                     /calculated_mol_wt=40326
     Region          55..143
                     /region_name="DCX1_DCLK1"
                     /note="Dublecortin-like domain 1 found in
                     doublecortin-like kinase 1 (DCLK1); cd17140"
                     /db_xref="CDD:340660"
     Site            order(55,66..68,74,79..80,82,90,98..100,102..103,106,133)
                     /site_type="other"
                     /note="putative tubulin binding site [polypeptide
                     binding]"
                     /db_xref="CDD:340660"
     Site            order(70,115)
                     /site_type="other"
                     /note="key conserved lysines"
                     /db_xref="CDD:340660"
     Region          182..265
                     /region_name="DCX2"
                     /note="Dublecortin-like domain 2; cd17069"
                     /db_xref="CDD:340589"
     Site            order(184,195..197,203,208..209,211,219,228..229,232,259)
                     /site_type="other"
                     /note="putative DCX-stabilized microtubules [polypeptide
                     binding]"
                     /db_xref="CDD:340589"
     Site            order(199,240)
                     /site_type="other"
                     /note="key conserved lysines"
                     /db_xref="CDD:340589"
     CDS             1..363
                     /gene="DCLK1"
                     /gene_synonym="CL1; CLICK1; DCAMKL1; DCDC3A; DCLK"
                     /coded_by="XM_047430767.1:190..1281"
                     /db_xref="GeneID:9201"
                     /db_xref="HGNC:HGNC:2700"
                     /db_xref="MIM:604742"
ORIGIN      
        1 msfgrdmele hfderdkaqr ysrgsrvngl pspthsahcs fyrtrtlqtl ssekkakkvr
       61 fyrngdryfk givyaispdr frsfeallad ltrtlsdnvn lpqgvrtiyt idglkkissl
      121 dqlvegesyv cgsiepfkkl eytknvnpnw svnvkttsas ravsslatak gspsevrenk
      181 dfirpklvti irsgvkprka vrillnkkta hsfeqvltdi tdaikldsgv vkrlytldgk
      241 qvmclqdffg dddifiacgp ekfryqddfl ldesecrvvk stsytkiass srrsttkspg
      301 psrrskspas tssvngtpgs qlstprsgks pspsptspgs lrkqrdlyrp lssddldsvg
      361 dsv
//
LOCUS       XP_011533611             696 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger MYM-type protein 5 isoform X1 [Homo sapiens].
ACCESSION   XP_011533611
VERSION     XP_011533611.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535309.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..696
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..696
                     /product="zinc finger MYM-type protein 5 isoform X1"
                     /calculated_mol_wt=77661
     Region          271..307
                     /region_name="TRASH"
                     /note="metallochaperone-like domain; smart00746"
                     /db_xref="CDD:214799"
     Region          361..396
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          402..442
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          590..665
                     /region_name="ZnF_TTF"
                     /note="zinc finger in transposases and transcription
                     factors; smart00597"
                     /db_xref="CDD:214739"
     CDS             1..696
                     /gene="ZMYM5"
                     /gene_synonym="HSPC050; MYM; ZNF198L1; ZNF237"
                     /coded_by="XM_011535309.3:544..2634"
                     /db_xref="GeneID:9205"
                     /db_xref="HGNC:HGNC:13029"
                     /db_xref="MIM:616443"
ORIGIN      
        1 mdqespsslc realaeikke isplfigmek csvgglelte qtpallgnma matslmdigd
       61 sfghpacplv srsrnspved ddddddvvfi esiqppsisa paiadqrnfi fassknekpq
      121 gnysvippss rdlasqkgni setividdee dietnggaek ksscfiewgl pgtknktndl
      181 dfstsslsrs ktktgvrpfn pgrmnvagdl fqngefathh spdswisqsa sfpsnqkqpg
      241 vdslspvall rkqnfqptaq qqltkpakit canckkplqk gqtayqrkgs ahlfcsttcl
      301 ssfshkrtqn trsiickkda stkkanvilp vessksfqef ystsclspce nnwnlkkgvf
      361 nksrcticsk laeirhevsv nnvthklcsn hcfnkyrlan glimnccehc geympskstg
      421 nnilviggqq krfccqscin eykqmmetks kkltasenrk rnafreenek qlygssntll
      481 kkiegipekk ektsqlqlsv ecgtdtlliq envnlppsst stiadtfqeq leeknfedsi
      541 vpvvlsadpg twprilnikq rdtlvenvpp qvrnfnfpkd ntgrkfsety ytrilpngek
      601 ttrswllyst skdsvfclyc klfgegknql knengckdwq hlshilskhe esemhvnnsv
      661 kysklksdlk knkaidaaeh rlyenekndg vlllyt
//
LOCUS       XP_006719957             669 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger MYM-type protein 5 isoform X2 [Homo sapiens].
ACCESSION   XP_006719957
VERSION     XP_006719957.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006719894.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..669
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..669
                     /product="zinc finger MYM-type protein 5 isoform X2"
                     /calculated_mol_wt=74687
     Region          244..280
                     /region_name="TRASH"
                     /note="metallochaperone-like domain; smart00746"
                     /db_xref="CDD:214799"
     Region          334..369
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          375..415
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          563..638
                     /region_name="ZnF_TTF"
                     /note="zinc finger in transposases and transcription
                     factors; smart00597"
                     /db_xref="CDD:214739"
     CDS             1..669
                     /gene="ZMYM5"
                     /gene_synonym="HSPC050; MYM; ZNF198L1; ZNF237"
                     /coded_by="XM_006719894.4:594..2603"
                     /db_xref="GeneID:9205"
                     /db_xref="HGNC:HGNC:13029"
                     /db_xref="MIM:616443"
ORIGIN      
        1 mekcsvggle lteqtpallg nmamatslmd igdsfghpac plvsrsrnsp vedddddddv
       61 vfiesiqpps isapaiadqr nfifasskne kpqgnysvip pssrdlasqk gnisetivid
      121 deedietngg aekksscfie wglpgtknkt ndldfstssl srsktktgvr pfnpgrmnva
      181 gdlfqngefa thhspdswis qsasfpsnqk qpgvdslspv allrkqnfqp taqqqltkpa
      241 kitcanckkp lqkgqtayqr kgsahlfcst tclssfshkr tqntrsiick kdastkkanv
      301 ilpvessksf qefystscls pcennwnlkk gvfnksrcti csklaeirhe vsvnnvthkl
      361 csnhcfnkyr langlimncc ehcgeympsk stgnnilvig gqqkrfccqs cineykqmme
      421 tkskkltase nrkrnafree nekqlygssn tllkkiegip ekkektsqlq lsvecgtdtl
      481 liqenvnlpp sststiadtf qeqleeknfe dsivpvvlsa dpgtwpriln ikqrdtlven
      541 vppqvrnfnf pkdntgrkfs etyytrilpn gekttrswll ystskdsvfc lycklfgegk
      601 nqlknengck dwqhlshils kheesemhvn nsvkysklks dlkknkaida aehrlyenek
      661 ndgvlllyt
//
LOCUS       XP_005266651             669 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger MYM-type protein 5 isoform X2 [Homo sapiens].
ACCESSION   XP_005266651
VERSION     XP_005266651.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266594.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..669
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..669
                     /product="zinc finger MYM-type protein 5 isoform X2"
                     /calculated_mol_wt=74687
     Region          244..280
                     /region_name="TRASH"
                     /note="metallochaperone-like domain; smart00746"
                     /db_xref="CDD:214799"
     Region          334..369
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          375..415
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          563..638
                     /region_name="ZnF_TTF"
                     /note="zinc finger in transposases and transcription
                     factors; smart00597"
                     /db_xref="CDD:214739"
     CDS             1..669
                     /gene="ZMYM5"
                     /gene_synonym="HSPC050; MYM; ZNF198L1; ZNF237"
                     /coded_by="XM_005266594.4:211..2220"
                     /db_xref="GeneID:9205"
                     /db_xref="HGNC:HGNC:13029"
                     /db_xref="MIM:616443"
ORIGIN      
        1 mekcsvggle lteqtpallg nmamatslmd igdsfghpac plvsrsrnsp vedddddddv
       61 vfiesiqpps isapaiadqr nfifasskne kpqgnysvip pssrdlasqk gnisetivid
      121 deedietngg aekksscfie wglpgtknkt ndldfstssl srsktktgvr pfnpgrmnva
      181 gdlfqngefa thhspdswis qsasfpsnqk qpgvdslspv allrkqnfqp taqqqltkpa
      241 kitcanckkp lqkgqtayqr kgsahlfcst tclssfshkr tqntrsiick kdastkkanv
      301 ilpvessksf qefystscls pcennwnlkk gvfnksrcti csklaeirhe vsvnnvthkl
      361 csnhcfnkyr langlimncc ehcgeympsk stgnnilvig gqqkrfccqs cineykqmme
      421 tkskkltase nrkrnafree nekqlygssn tllkkiegip ekkektsqlq lsvecgtdtl
      481 liqenvnlpp sststiadtf qeqleeknfe dsivpvvlsa dpgtwpriln ikqrdtlven
      541 vppqvrnfnf pkdntgrkfs etyytrilpn gekttrswll ystskdsvfc lycklfgegk
      601 nqlknengck dwqhlshils kheesemhvn nsvkysklks dlkknkaida aehrlyenek
      661 ndgvlllyt
//
LOCUS       XP_011533612             514 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger MYM-type protein 5 isoform X3 [Homo sapiens].
ACCESSION   XP_011533612
VERSION     XP_011533612.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535310.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..514
                     /product="zinc finger MYM-type protein 5 isoform X3"
                     /calculated_mol_wt=57558
     Region          220..260
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          408..483
                     /region_name="ZnF_TTF"
                     /note="zinc finger in transposases and transcription
                     factors; smart00597"
                     /db_xref="CDD:214739"
     CDS             1..514
                     /gene="ZMYM5"
                     /gene_synonym="HSPC050; MYM; ZNF198L1; ZNF237"
                     /coded_by="XM_011535310.3:544..2088"
                     /db_xref="GeneID:9205"
                     /db_xref="HGNC:HGNC:13029"
                     /db_xref="MIM:616443"
ORIGIN      
        1 mdqespsslc realaeikke isplfigmek csvgglelte qtpallgnma matslmdigd
       61 sfghpacplv srsrnspved ddddddvvfi esiqppsisa paiadqrnfi fassknekpq
      121 gnysvippss rdlasqkgni setividdee dietnggaek ksscfiewgl pgtknktndl
      181 dfstsslsrs kirhevsvnn vthklcsnhc fnkyrlangl imnccehcge ympskstgnn
      241 ilviggqqkr fccqsciney kqmmetkskk ltasenrkrn afreenekql ygssntllkk
      301 iegipekkek tsqlqlsvec gtdtlliqen vnlppsstst iadtfqeqle eknfedsivp
      361 vvlsadpgtw prilnikqrd tlvenvppqv rnfnfpkdnt grkfsetyyt rilpngektt
      421 rswllystsk dsvfclyckl fgegknqlkn engckdwqhl shilskhees emhvnnsvky
      481 sklksdlkkn kaidaaehrl yenekndgvl llyt
//
LOCUS       XP_047286724             487 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger MYM-type protein 5 isoform X4 [Homo sapiens].
ACCESSION   XP_047286724
VERSION     XP_047286724.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430768.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..487
                     /product="zinc finger MYM-type protein 5 isoform X4"
                     /calculated_mol_wt=54584
     Region          193..233
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          381..456
                     /region_name="ZnF_TTF"
                     /note="zinc finger in transposases and transcription
                     factors; smart00597"
                     /db_xref="CDD:214739"
     CDS             1..487
                     /gene="ZMYM5"
                     /gene_synonym="HSPC050; MYM; ZNF198L1; ZNF237"
                     /coded_by="XM_047430768.1:279..1742"
                     /db_xref="GeneID:9205"
                     /db_xref="HGNC:HGNC:13029"
                     /db_xref="MIM:616443"
ORIGIN      
        1 mekcsvggle lteqtpallg nmamatslmd igdsfghpac plvsrsrnsp vedddddddv
       61 vfiesiqpps isapaiadqr nfifasskne kpqgnysvip pssrdlasqk gnisetivid
      121 deedietngg aekksscfie wglpgtknkt ndldfstssl srskirhevs vnnvthklcs
      181 nhcfnkyrla nglimncceh cgeympskst gnnilviggq qkrfccqsci neykqmmetk
      241 skkltasenr krnafreene kqlygssntl lkkiegipek kektsqlqls vecgtdtlli
      301 qenvnlppss tstiadtfqe qleeknfeds ivpvvlsadp gtwprilnik qrdtlvenvp
      361 pqvrnfnfpk dntgrkfset yytrilpnge kttrswllys tskdsvfcly cklfgegknq
      421 lknengckdw qhlshilskh eesemhvnns vkysklksdl kknkaidaae hrlyeneknd
      481 gvlllyt
//
LOCUS       XP_047286725             487 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger MYM-type protein 5 isoform X4 [Homo sapiens].
ACCESSION   XP_047286725
VERSION     XP_047286725.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430769.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..487
                     /product="zinc finger MYM-type protein 5 isoform X4"
                     /calculated_mol_wt=54584
     Region          193..233
                     /region_name="zf-FCS"
                     /note="MYM-type Zinc finger with FCS sequence motif;
                     pfam06467"
                     /db_xref="CDD:428958"
     Region          381..456
                     /region_name="ZnF_TTF"
                     /note="zinc finger in transposases and transcription
                     factors; smart00597"
                     /db_xref="CDD:214739"
     CDS             1..487
                     /gene="ZMYM5"
                     /gene_synonym="HSPC050; MYM; ZNF198L1; ZNF237"
                     /coded_by="XM_047430769.1:211..1674"
                     /db_xref="GeneID:9205"
                     /db_xref="HGNC:HGNC:13029"
                     /db_xref="MIM:616443"
ORIGIN      
        1 mekcsvggle lteqtpallg nmamatslmd igdsfghpac plvsrsrnsp vedddddddv
       61 vfiesiqpps isapaiadqr nfifasskne kpqgnysvip pssrdlasqk gnisetivid
      121 deedietngg aekksscfie wglpgtknkt ndldfstssl srskirhevs vnnvthklcs
      181 nhcfnkyrla nglimncceh cgeympskst gnnilviggq qkrfccqsci neykqmmetk
      241 skkltasenr krnafreene kqlygssntl lkkiegipek kektsqlqls vecgtdtlli
      301 qenvnlppss tstiadtfqe qleeknfeds ivpvvlsadp gtwprilnik qrdtlvenvp
      361 pqvrnfnfpk dntgrkfset yytrilpnge kttrswllys tskdsvfcly cklfgegknq
      421 lknengckdw qhlshilskh eesemhvnns vkysklksdl kknkaidaae hrlyeneknd
      481 gvlllyt
//
LOCUS       XP_024305204             324 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger MYM-type protein 5 isoform X5 [Homo sapiens].
ACCESSION   XP_024305204
VERSION     XP_024305204.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449436.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..324
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..324
                     /product="zinc finger MYM-type protein 5 isoform X5"
                     /calculated_mol_wt=35084
     Region          271..307
                     /region_name="TRASH"
                     /note="metallochaperone-like domain; smart00746"
                     /db_xref="CDD:214799"
     CDS             1..324
                     /gene="ZMYM5"
                     /gene_synonym="HSPC050; MYM; ZNF198L1; ZNF237"
                     /coded_by="XM_024449436.2:22..996"
                     /db_xref="GeneID:9205"
                     /db_xref="HGNC:HGNC:13029"
                     /db_xref="MIM:616443"
ORIGIN      
        1 mdqespsslc realaeikke isplfigmek csvgglelte qtpallgnma matslmdigd
       61 sfghpacplv srsrnspved ddddddvvfi esiqppsisa paiadqrnfi fassknekpq
      121 gnysvippss rdlasqkgni setividdee dietnggaek ksscfiewgl pgtknktndl
      181 dfstsslsrs ktktgvrpfn pgrmnvagdl fqngefathh spdswisqsa sfpsnqkqpg
      241 vdslspvall rkqnfqptaq qqltkpakit canckkplqk gqtayqrkgs ahlfcsttcl
      301 ssfshkrtqn trsiickkfa mksa
//
LOCUS       XP_016876340             235 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger MYM-type protein 5 isoform X6 [Homo sapiens].
ACCESSION   XP_016876340
VERSION     XP_016876340.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020851.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..235
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..235
                     /product="zinc finger MYM-type protein 5 isoform X6"
                     /calculated_mol_wt=25531
     Region          <96..>184
                     /region_name="Periplasmic_Binding_Protein_type1"
                     /note="Type 1 periplasmic binding fold superfamily;
                     cl10011"
                     /db_xref="CDD:471960"
     CDS             1..235
                     /gene="ZMYM5"
                     /gene_synonym="HSPC050; MYM; ZNF198L1; ZNF237"
                     /coded_by="XM_017020851.3:23..730"
                     /db_xref="GeneID:9205"
                     /db_xref="HGNC:HGNC:13029"
                     /db_xref="MIM:616443"
ORIGIN      
        1 mdqespsslc realaeikke isplfigmek csvgglelte qtpallgnma matslmdigd
       61 sfghpacplv srsrnspved ddddddvvfi esiqppsisa paiadqrnfi fassknekpq
      121 gnysvippss rdlasqkgni setividdee dietnggaek ksscfiewgl pgtknktndl
      181 dfstsslsrs ktktgvrpfn pgrmnvagdl fqngefathh spemhlqrrl msffq
//
LOCUS       XP_024305205             225 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger MYM-type protein 5 isoform X7 [Homo sapiens].
ACCESSION   XP_024305205
VERSION     XP_024305205.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449437.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..225
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..225
                     /product="zinc finger MYM-type protein 5 isoform X7"
                     /calculated_mol_wt=24125
     Region          <96..>184
                     /region_name="Periplasmic_Binding_Protein_type1"
                     /note="Type 1 periplasmic binding fold superfamily;
                     cl10011"
                     /db_xref="CDD:471960"
     CDS             1..225
                     /gene="ZMYM5"
                     /gene_synonym="HSPC050; MYM; ZNF198L1; ZNF237"
                     /coded_by="XM_024449437.2:22..699"
                     /db_xref="GeneID:9205"
                     /db_xref="HGNC:HGNC:13029"
                     /db_xref="MIM:616443"
ORIGIN      
        1 mdqespsslc realaeikke isplfigmek csvgglelte qtpallgnma matslmdigd
       61 sfghpacplv srsrnspved ddddddvvfi esiqppsisa paiadqrnfi fassknekpq
      121 gnysvippss rdlasqkgni setividdee dietnggaek ksscfiewgl pgtknktndl
      181 dfstsslsrs ktktgvrpfn pgrmnvagdl fqngefathh spdsp
//
LOCUS       XP_047286726             208 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger MYM-type protein 5 isoform X8 [Homo sapiens].
ACCESSION   XP_047286726
VERSION     XP_047286726.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430770.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..208
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..208
                     /product="zinc finger MYM-type protein 5 isoform X8"
                     /calculated_mol_wt=22556
     Region          <69..>157
                     /region_name="Periplasmic_Binding_Protein_type1"
                     /note="Type 1 periplasmic binding fold superfamily;
                     cl10011"
                     /db_xref="CDD:471960"
     CDS             1..208
                     /gene="ZMYM5"
                     /gene_synonym="HSPC050; MYM; ZNF198L1; ZNF237"
                     /coded_by="XM_047430770.1:594..1220"
                     /db_xref="GeneID:9205"
                     /db_xref="HGNC:HGNC:13029"
                     /db_xref="MIM:616443"
ORIGIN      
        1 mekcsvggle lteqtpallg nmamatslmd igdsfghpac plvsrsrnsp vedddddddv
       61 vfiesiqpps isapaiadqr nfifasskne kpqgnysvip pssrdlasqk gnisetivid
      121 deedietngg aekksscfie wglpgtknkt ndldfstssl srsktktgvr pfnpgrmnva
      181 gdlfqngefa thhspemhlq rrlmsffq
//
LOCUS       XP_047286727             208 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger MYM-type protein 5 isoform X8 [Homo sapiens].
ACCESSION   XP_047286727
VERSION     XP_047286727.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430771.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..208
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..208
                     /product="zinc finger MYM-type protein 5 isoform X8"
                     /calculated_mol_wt=22556
     Region          <69..>157
                     /region_name="Periplasmic_Binding_Protein_type1"
                     /note="Type 1 periplasmic binding fold superfamily;
                     cl10011"
                     /db_xref="CDD:471960"
     CDS             1..208
                     /gene="ZMYM5"
                     /gene_synonym="HSPC050; MYM; ZNF198L1; ZNF237"
                     /coded_by="XM_047430771.1:211..837"
                     /db_xref="GeneID:9205"
                     /db_xref="HGNC:HGNC:13029"
                     /db_xref="MIM:616443"
ORIGIN      
        1 mekcsvggle lteqtpallg nmamatslmd igdsfghpac plvsrsrnsp vedddddddv
       61 vfiesiqpps isapaiadqr nfifasskne kpqgnysvip pssrdlasqk gnisetivid
      121 deedietngg aekksscfie wglpgtknkt ndldfstssl srsktktgvr pfnpgrmnva
      181 gdlfqngefa thhspemhlq rrlmsffq
//
LOCUS       XP_047286728             198 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger MYM-type protein 5 isoform X9 [Homo sapiens].
ACCESSION   XP_047286728
VERSION     XP_047286728.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430772.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..198
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..198
                     /product="zinc finger MYM-type protein 5 isoform X9"
                     /calculated_mol_wt=21150
     Region          <69..>157
                     /region_name="Periplasmic_Binding_Protein_type1"
                     /note="Type 1 periplasmic binding fold superfamily;
                     cl10011"
                     /db_xref="CDD:471960"
     CDS             1..198
                     /gene="ZMYM5"
                     /gene_synonym="HSPC050; MYM; ZNF198L1; ZNF237"
                     /coded_by="XM_047430772.1:594..1190"
                     /db_xref="GeneID:9205"
                     /db_xref="HGNC:HGNC:13029"
                     /db_xref="MIM:616443"
ORIGIN      
        1 mekcsvggle lteqtpallg nmamatslmd igdsfghpac plvsrsrnsp vedddddddv
       61 vfiesiqpps isapaiadqr nfifasskne kpqgnysvip pssrdlasqk gnisetivid
      121 deedietngg aekksscfie wglpgtknkt ndldfstssl srsktktgvr pfnpgrmnva
      181 gdlfqngefa thhspdsp
//
LOCUS       XP_047286729             227 aa            linear   PRI 05-AUG-2025
DEFINITION  testis-expressed protein 30 isoform X1 [Homo sapiens].
ACCESSION   XP_047286729
VERSION     XP_047286729.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430773.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..227
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..227
                     /product="testis-expressed protein 30 isoform X1"
                     /calculated_mol_wt=25454
     Region          31..220
                     /region_name="COG3571"
                     /note="Predicted hydrolase of the alpha/beta-hydrolase
                     fold [General function prediction only]"
                     /db_xref="CDD:442792"
     CDS             1..227
                     /gene="TEX30"
                     /gene_synonym="C13orf27"
                     /coded_by="XM_047430773.1:1981..2664"
                     /db_xref="GeneID:93081"
                     /db_xref="HGNC:HGNC:25188"
ORIGIN      
        1 mshtevklki pfgnklldav clvpnkslty giilthgasg dmnlphlmsl ashlashgff
       61 clrftckgln ivhrikayks vlnylktsge yklagvflgg rsmgsraaas vmchiepddg
      121 ddfvrglici syplhhpkqq hklrdedlfr lkepvlfvsg sademceknl lekvaqkmqa
      181 phkihwieka nhsmavkgrs tndvfkeint qilfwiqeit emdkkch
//
LOCUS       XP_016876341             227 aa            linear   PRI 05-AUG-2025
DEFINITION  testis-expressed protein 30 isoform X1 [Homo sapiens].
ACCESSION   XP_016876341
VERSION     XP_016876341.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020852.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..227
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..227
                     /product="testis-expressed protein 30 isoform X1"
                     /calculated_mol_wt=25454
     Region          31..220
                     /region_name="COG3571"
                     /note="Predicted hydrolase of the alpha/beta-hydrolase
                     fold [General function prediction only]"
                     /db_xref="CDD:442792"
     CDS             1..227
                     /gene="TEX30"
                     /gene_synonym="C13orf27"
                     /coded_by="XM_017020852.3:2325..3008"
                     /db_xref="GeneID:93081"
                     /db_xref="HGNC:HGNC:25188"
ORIGIN      
        1 mshtevklki pfgnklldav clvpnkslty giilthgasg dmnlphlmsl ashlashgff
       61 clrftckgln ivhrikayks vlnylktsge yklagvflgg rsmgsraaas vmchiepddg
      121 ddfvrglici syplhhpkqq hklrdedlfr lkepvlfvsg sademceknl lekvaqkmqa
      181 phkihwieka nhsmavkgrs tndvfkeint qilfwiqeit emdkkch
//
LOCUS       XP_024305207             227 aa            linear   PRI 05-AUG-2025
DEFINITION  testis-expressed protein 30 isoform X1 [Homo sapiens].
ACCESSION   XP_024305207
VERSION     XP_024305207.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449439.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..227
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..227
                     /product="testis-expressed protein 30 isoform X1"
                     /calculated_mol_wt=25454
     Region          31..220
                     /region_name="COG3571"
                     /note="Predicted hydrolase of the alpha/beta-hydrolase
                     fold [General function prediction only]"
                     /db_xref="CDD:442792"
     CDS             1..227
                     /gene="TEX30"
                     /gene_synonym="C13orf27"
                     /coded_by="XM_024449439.2:241..924"
                     /db_xref="GeneID:93081"
                     /db_xref="HGNC:HGNC:25188"
ORIGIN      
        1 mshtevklki pfgnklldav clvpnkslty giilthgasg dmnlphlmsl ashlashgff
       61 clrftckgln ivhrikayks vlnylktsge yklagvflgg rsmgsraaas vmchiepddg
      121 ddfvrglici syplhhpkqq hklrdedlfr lkepvlfvsg sademceknl lekvaqkmqa
      181 phkihwieka nhsmavkgrs tndvfkeint qilfwiqeit emdkkch
//
LOCUS       XP_005254154             227 aa            linear   PRI 05-AUG-2025
DEFINITION  testis-expressed protein 30 isoform X1 [Homo sapiens].
ACCESSION   XP_005254154
VERSION     XP_005254154.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254097.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..227
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..227
                     /product="testis-expressed protein 30 isoform X1"
                     /calculated_mol_wt=25454
     Region          31..220
                     /region_name="COG3571"
                     /note="Predicted hydrolase of the alpha/beta-hydrolase
                     fold [General function prediction only]"
                     /db_xref="CDD:442792"
     CDS             1..227
                     /gene="TEX30"
                     /gene_synonym="C13orf27"
                     /coded_by="XM_005254097.4:367..1050"
                     /db_xref="GeneID:93081"
                     /db_xref="HGNC:HGNC:25188"
ORIGIN      
        1 mshtevklki pfgnklldav clvpnkslty giilthgasg dmnlphlmsl ashlashgff
       61 clrftckgln ivhrikayks vlnylktsge yklagvflgg rsmgsraaas vmchiepddg
      121 ddfvrglici syplhhpkqq hklrdedlfr lkepvlfvsg sademceknl lekvaqkmqa
      181 phkihwieka nhsmavkgrs tndvfkeint qilfwiqeit emdkkch
//
LOCUS       XP_011519438             183 aa            linear   PRI 05-AUG-2025
DEFINITION  testis-expressed protein 30 isoform X2 [Homo sapiens].
ACCESSION   XP_011519438
VERSION     XP_011519438.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521136.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..183
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..183
                     /product="testis-expressed protein 30 isoform X2"
                     /calculated_mol_wt=21113
     Region          <52..176
                     /region_name="COG3571"
                     /note="Predicted hydrolase of the alpha/beta-hydrolase
                     fold [General function prediction only]"
                     /db_xref="CDD:442792"
     CDS             1..183
                     /gene="TEX30"
                     /gene_synonym="C13orf27"
                     /coded_by="XM_011521136.3:101..652"
                     /db_xref="GeneID:93081"
                     /db_xref="HGNC:HGNC:25188"
ORIGIN      
        1 mflrdiakea tydfspwnyv tlahhfgile yfiyhtmhny lktsgeykla gvflggrsmg
       61 sraaasvmch iepddgddfv rglicisypl hhpkqqhklr dedlfrlkep vlfvsgsade
      121 mceknllekv aqkmqaphki hwiekanhsm avkgrstndv fkeintqilf wiqeitemdk
      181 kch
//
LOCUS       XP_047286730             113 aa            linear   PRI 05-AUG-2025
DEFINITION  testis-expressed protein 30 isoform X3 [Homo sapiens].
ACCESSION   XP_047286730
VERSION     XP_047286730.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430774.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..113
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..113
                     /product="testis-expressed protein 30 isoform X3"
                     /calculated_mol_wt=12089
     Region          31..>64
                     /region_name="COG3571"
                     /note="Predicted hydrolase of the alpha/beta-hydrolase
                     fold [General function prediction only]"
                     /db_xref="CDD:442792"
     CDS             1..113
                     /gene="TEX30"
                     /gene_synonym="C13orf27"
                     /coded_by="XM_047430774.1:399..740"
                     /db_xref="GeneID:93081"
                     /db_xref="HGNC:HGNC:25188"
ORIGIN      
        1 mshtevklki pfgnklldav clvpnkslty giilthgasg dmnlphlmsl ashlashgff
       61 clrftckgln ivhrikayks vlnylktsge yklagvflge lvgesgtena ssp
//
LOCUS       XP_006719958             705 aa            linear   PRI 05-AUG-2025
DEFINITION  klotho isoform X1 [Homo sapiens].
ACCESSION   XP_006719958
VERSION     XP_006719958.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006719895.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..705
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..705
                     /product="klotho isoform X1"
                     /calculated_mol_wt=82022
     Region          <6..199
                     /region_name="Glycosyl hydrolases"
                     /note="A functionally diverse superfamily containing
                     glycosyl hydrolase families 1,5,10,17,44,72, and others;
                     cl23725"
                     /db_xref="CDD:474034"
     Region          210..646
                     /region_name="Glycosyl hydrolases"
                     /note="A functionally diverse superfamily containing
                     glycosyl hydrolase families 1,5,10,17,44,72, and others;
                     cl23725"
                     /db_xref="CDD:474034"
     CDS             1..705
                     /gene="KL"
                     /gene_synonym="HFTC3; KLA"
                     /coded_by="XM_006719895.3:174..2291"
                     /db_xref="GeneID:9365"
                     /db_xref="HGNC:HGNC:6344"
                     /db_xref="MIM:604824"
ORIGIN      
        1 mtdhsikecq ksldfvlgwf akpvfidgdy pesmknnlss ilpdftesek kfikgtadff
       61 alcfgptlsf qlldphmkfr qlespnlrql lswidlefnh pqifivengw fvsgttkrdd
      121 akymyylkkf imetlkaikl dgvdvigyta wslmdgfewh rgysirrglf yvdflsqdkm
      181 llpkssalfy qkliekngfp plpenqpleg tfpcdfawgv vdnyiqvdtt lsqftdlnvy
      241 lwdvhhskrl ikvdgvvtkk rksycvdfaa iqpqiallqe mhvthfrfsl dwalilplgn
      301 qsqvnhtilq yyrcmaselv rvnitpvval wqpmapnqgl prllarqgaw enpytalafa
      361 eyarlcfqel ghhvklwitm nepytrnmty saghnllkah alawhvynek frhaqngkis
      421 ialqadwiep acpfsqkdke vaervlefdi gwlaepifgs gdypwvmrdw lnqrnnfllp
      481 yftedekkli qgtfdflals hyttilvdse kedpikyndy levqemtdit wlnspsqvav
      541 vpwglrkvln wlkfkygdlp myiisngidd glhaeddqlr vyymqnyine alkahildgi
      601 nlcgyfaysf ndrtaprfgl yryaadqfep kasmkhyrki idsngfpgpe tlerfcpeef
      661 tvctecsffh trksllafia flffasiisl slifyyskkg rrsyk
//
LOCUS       XP_047286731             594 aa            linear   PRI 05-AUG-2025
DEFINITION  klotho isoform X2 [Homo sapiens].
ACCESSION   XP_047286731
VERSION     XP_047286731.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430775.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..594
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..594
                     /product="klotho isoform X2"
                     /calculated_mol_wt=67488
     Region          58..506
                     /region_name="Glycosyl hydrolases"
                     /note="A functionally diverse superfamily containing
                     glycosyl hydrolase families 1,5,10,17,44,72, and others;
                     cl23725"
                     /db_xref="CDD:474034"
     CDS             1..594
                     /gene="KL"
                     /gene_synonym="HFTC3; KLA"
                     /coded_by="XM_047430775.1:19..1803"
                     /db_xref="GeneID:9365"
                     /db_xref="HGNC:HGNC:6344"
                     /db_xref="MIM:604824"
ORIGIN      
        1 mpasapprrp rppppslsll lvllglggrr lraepgdgaq twarfsrppa peaaglfqgt
       61 fpdgflwavg saayqteggw qqhgkgasiw dtfthhplap pgdsrnaslp lgapsplqpa
      121 tgdvasdsyn nvfrdtealr elgvthyrfs iswarvlpng sagvpnregl ryyrrllerl
      181 relgvqpvvt lyhwdlpqrl qdayggwanr aladhfrdya elcfrhfggq vkywitidnp
      241 yvvawhgyat grlapgirgs prlgylvahn lllahakvwh lyntsfrptq ggqvsialss
      301 hwinprrmtd hsikecqksl dfvlgwfakp vfidgdypes mknnlssilp dftesekkfi
      361 kgtadffalc fgptlsfqll dphmkfrqle spnlrqllsw idlefnhpqi fivengwfvs
      421 gttkrddaky myylkkfime tlkaikldgv dvigytawsl mdgfewhrgy sirrglfyvd
      481 flsqdkmllp kssalfyqkl iekngfpplp enqplegtfp cdfawgvvdn yiqvsqltkp
      541 issltkpyhy isdfqclrha fhlnnlknni lrstqpdfrl ihmdchftwt hflg
//
LOCUS       XP_047286732             549 aa            linear   PRI 05-AUG-2025
DEFINITION  klotho isoform X3 [Homo sapiens].
ACCESSION   XP_047286732
VERSION     XP_047286732.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430776.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..549
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..549
                     /product="klotho isoform X3"
                     /calculated_mol_wt=62004
     Region          58..506
                     /region_name="Glycosyl hydrolases"
                     /note="A functionally diverse superfamily containing
                     glycosyl hydrolase families 1,5,10,17,44,72, and others;
                     cl23725"
                     /db_xref="CDD:474034"
     CDS             1..549
                     /gene="KL"
                     /gene_synonym="HFTC3; KLA"
                     /coded_by="XM_047430776.1:19..1668"
                     /db_xref="GeneID:9365"
                     /db_xref="HGNC:HGNC:6344"
                     /db_xref="MIM:604824"
ORIGIN      
        1 mpasapprrp rppppslsll lvllglggrr lraepgdgaq twarfsrppa peaaglfqgt
       61 fpdgflwavg saayqteggw qqhgkgasiw dtfthhplap pgdsrnaslp lgapsplqpa
      121 tgdvasdsyn nvfrdtealr elgvthyrfs iswarvlpng sagvpnregl ryyrrllerl
      181 relgvqpvvt lyhwdlpqrl qdayggwanr aladhfrdya elcfrhfggq vkywitidnp
      241 yvvawhgyat grlapgirgs prlgylvahn lllahakvwh lyntsfrptq ggqvsialss
      301 hwinprrmtd hsikecqksl dfvlgwfakp vfidgdypes mknnlssilp dftesekkfi
      361 kgtadffalc fgptlsfqll dphmkfrqle spnlrqllsw idlefnhpqi fivengwfvs
      421 gttkrddaky myylkkfime tlkaikldgv dvigytawsl mdgfewhrgy sirrglfyvd
      481 flsqdkmllp kssalfyqkl iekngfpplp enqplegtfp cdfawgvvdn yiqvsqltkp
      541 issltkpyh
//
LOCUS       XP_005266653             399 aa            linear   PRI 05-AUG-2025
DEFINITION  epithelial-stromal interaction protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_005266653
VERSION     XP_005266653.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266596.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..399
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..399
                     /product="epithelial-stromal interaction protein 1 isoform
                     X1"
                     /calculated_mol_wt=46015
     Region          <75..>272
                     /region_name="DUF5401"
                     /note="Family of unknown function (DUF5401); pfam17380"
                     /db_xref="CDD:375164"
     CDS             1..399
                     /gene="EPSTI1"
                     /gene_synonym="BRESI1"
                     /coded_by="XM_005266596.2:77..1276"
                     /db_xref="GeneID:94240"
                     /db_xref="HGNC:HGNC:16465"
                     /db_xref="MIM:607441"
ORIGIN      
        1 mntrnrvvns glgaspasrp trdpqdpsgr qgelspvedq regleaapkg psresvvhag
       61 qrrtsaytli apninrrnei qriaeqelan lekwkeqnra kpvhlvprrl ggsqsetevr
      121 qkqqlqlmqs kykqklkree svrikkeaee aelqkmkaiq reksnkleek krlqenlrre
      181 afrehqqykt aeflsklnte spdrsacqsa vcgpqsstwa rswayrdslk aeenrklqkm
      241 kdeqhqksel lelkrqqqeq erakihqteh rrvnnafldr lqgksqpggl eqsggcwnmn
      301 sgnswgsllv fsrhlrvyek iltpiwpsst dlekphemlf lnvilfsltv ftlistahtl
      361 dravrsdwll lvliyaclee lipelifnly cqgnatlff
//
LOCUS       XP_006719959             309 aa            linear   PRI 05-AUG-2025
DEFINITION  epithelial-stromal interaction protein 1 isoform X2 [Homo sapiens].
ACCESSION   XP_006719959
VERSION     XP_006719959.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006719896.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..309
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..309
                     /product="epithelial-stromal interaction protein 1 isoform
                     X2"
                     /calculated_mol_wt=35902
     Region          <75..>283
                     /region_name="DUF5401"
                     /note="Family of unknown function (DUF5401); pfam17380"
                     /db_xref="CDD:375164"
     CDS             1..309
                     /gene="EPSTI1"
                     /gene_synonym="BRESI1"
                     /coded_by="XM_006719896.5:77..1006"
                     /db_xref="GeneID:94240"
                     /db_xref="HGNC:HGNC:16465"
                     /db_xref="MIM:607441"
ORIGIN      
        1 mntrnrvvns glgaspasrp trdpqdpsgr qgelspvedq regleaapkg psresvvhag
       61 qrrtsaytli apninrrnei qriaeqelan lekwkeqnra kpvhlvprrl ggsqsetevr
      121 qkqqlqlmqs kykqklkree svrikkeaee aelqkmkaiq reksnkleek krlqenlrre
      181 afrehqqykt aeflsklnte spdrsacqsa vcgpqsstwk lpilprdhsw arswayrdsl
      241 kaeenrklqk mkdeqhqkse llelkrqqqe qerakihqte hrrgeervpg rfvsfsnyii
      301 rlhsikavs
//
LOCUS       XP_047286734             283 aa            linear   PRI 05-AUG-2025
DEFINITION  epithelial-stromal interaction protein 1 isoform X3 [Homo sapiens].
ACCESSION   XP_047286734
VERSION     XP_047286734.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430778.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 29% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..283
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..283
                     /product="epithelial-stromal interaction protein 1 isoform
                     X3"
                     /calculated_mol_wt=33170
     Region          <7..157
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     CDS             1..283
                     /gene="EPSTI1"
                     /gene_synonym="BRESI1"
                     /coded_by="XM_047430778.1:3292..4143"
                     /db_xref="GeneID:94240"
                     /db_xref="HGNC:HGNC:16465"
                     /db_xref="MIM:607441"
ORIGIN      
        1 mqskykqklk reesvrikke aeeaelqkmk aiqreksnkl eekkrlqenl rreafrehqq
       61 yktaeflskl ntespdrsac qsavcgpqss twklpilprd hswarswayr dslkaeenrk
      121 lqkmkdeqhq ksellelkrq qqeqerakih qtehrrvnna fldrlqgksq pggleqsggc
      181 wnmnsgnswg sllvfsrhlr vyekiltpiw psstdlekph emlflnvilf sltvftlist
      241 ahtldravrs dwlllvliya cleelipeli fnlycqgnat lff
//
LOCUS       XP_047286735             283 aa            linear   PRI 05-AUG-2025
DEFINITION  epithelial-stromal interaction protein 1 isoform X3 [Homo sapiens].
ACCESSION   XP_047286735
VERSION     XP_047286735.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430779.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 29% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..283
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..283
                     /product="epithelial-stromal interaction protein 1 isoform
                     X3"
                     /calculated_mol_wt=33170
     Region          <7..157
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     CDS             1..283
                     /gene="EPSTI1"
                     /gene_synonym="BRESI1"
                     /coded_by="XM_047430779.1:1968..2819"
                     /db_xref="GeneID:94240"
                     /db_xref="HGNC:HGNC:16465"
                     /db_xref="MIM:607441"
ORIGIN      
        1 mqskykqklk reesvrikke aeeaelqkmk aiqreksnkl eekkrlqenl rreafrehqq
       61 yktaeflskl ntespdrsac qsavcgpqss twklpilprd hswarswayr dslkaeenrk
      121 lqkmkdeqhq ksellelkrq qqeqerakih qtehrrvnna fldrlqgksq pggleqsggc
      181 wnmnsgnswg sllvfsrhlr vyekiltpiw psstdlekph emlflnvilf sltvftlist
      241 ahtldravrs dwlllvliya cleelipeli fnlycqgnat lff
//
LOCUS       XP_011533614             283 aa            linear   PRI 05-AUG-2025
DEFINITION  epithelial-stromal interaction protein 1 isoform X3 [Homo sapiens].
ACCESSION   XP_011533614
VERSION     XP_011533614.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535312.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..283
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..283
                     /product="epithelial-stromal interaction protein 1 isoform
                     X3"
                     /calculated_mol_wt=33170
     Region          <7..157
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     CDS             1..283
                     /gene="EPSTI1"
                     /gene_synonym="BRESI1"
                     /coded_by="XM_011535312.3:2165..3016"
                     /db_xref="GeneID:94240"
                     /db_xref="HGNC:HGNC:16465"
                     /db_xref="MIM:607441"
ORIGIN      
        1 mqskykqklk reesvrikke aeeaelqkmk aiqreksnkl eekkrlqenl rreafrehqq
       61 yktaeflskl ntespdrsac qsavcgpqss twklpilprd hswarswayr dslkaeenrk
      121 lqkmkdeqhq ksellelkrq qqeqerakih qtehrrvnna fldrlqgksq pggleqsggc
      181 wnmnsgnswg sllvfsrhlr vyekiltpiw psstdlekph emlflnvilf sltvftlist
      241 ahtldravrs dwlllvliya cleelipeli fnlycqgnat lff
//
LOCUS       XP_047286736             283 aa            linear   PRI 05-AUG-2025
DEFINITION  epithelial-stromal interaction protein 1 isoform X3 [Homo sapiens].
ACCESSION   XP_047286736
VERSION     XP_047286736.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430780.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 29% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..283
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..283
                     /product="epithelial-stromal interaction protein 1 isoform
                     X3"
                     /calculated_mol_wt=33170
     Region          <7..157
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     CDS             1..283
                     /gene="EPSTI1"
                     /gene_synonym="BRESI1"
                     /coded_by="XM_047430780.1:1287..2138"
                     /db_xref="GeneID:94240"
                     /db_xref="HGNC:HGNC:16465"
                     /db_xref="MIM:607441"
ORIGIN      
        1 mqskykqklk reesvrikke aeeaelqkmk aiqreksnkl eekkrlqenl rreafrehqq
       61 yktaeflskl ntespdrsac qsavcgpqss twklpilprd hswarswayr dslkaeenrk
      121 lqkmkdeqhq ksellelkrq qqeqerakih qtehrrvnna fldrlqgksq pggleqsggc
      181 wnmnsgnswg sllvfsrhlr vyekiltpiw psstdlekph emlflnvilf sltvftlist
      241 ahtldravrs dwlllvliya cleelipeli fnlycqgnat lff
//
LOCUS       XP_047286737             283 aa            linear   PRI 05-AUG-2025
DEFINITION  epithelial-stromal interaction protein 1 isoform X3 [Homo sapiens].
ACCESSION   XP_047286737
VERSION     XP_047286737.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430781.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 29% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..283
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..283
                     /product="epithelial-stromal interaction protein 1 isoform
                     X3"
                     /calculated_mol_wt=33170
     Region          <7..157
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     CDS             1..283
                     /gene="EPSTI1"
                     /gene_synonym="BRESI1"
                     /coded_by="XM_047430781.1:772..1623"
                     /db_xref="GeneID:94240"
                     /db_xref="HGNC:HGNC:16465"
                     /db_xref="MIM:607441"
ORIGIN      
        1 mqskykqklk reesvrikke aeeaelqkmk aiqreksnkl eekkrlqenl rreafrehqq
       61 yktaeflskl ntespdrsac qsavcgpqss twklpilprd hswarswayr dslkaeenrk
      121 lqkmkdeqhq ksellelkrq qqeqerakih qtehrrvnna fldrlqgksq pggleqsggc
      181 wnmnsgnswg sllvfsrhlr vyekiltpiw psstdlekph emlflnvilf sltvftlist
      241 ahtldravrs dwlllvliya cleelipeli fnlycqgnat lff
//
LOCUS       XP_016876344             283 aa            linear   PRI 05-AUG-2025
DEFINITION  epithelial-stromal interaction protein 1 isoform X3 [Homo sapiens].
ACCESSION   XP_016876344
VERSION     XP_016876344.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020855.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..283
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..283
                     /product="epithelial-stromal interaction protein 1 isoform
                     X3"
                     /calculated_mol_wt=33170
     Region          <7..157
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     CDS             1..283
                     /gene="EPSTI1"
                     /gene_synonym="BRESI1"
                     /coded_by="XM_017020855.3:1180..2031"
                     /db_xref="GeneID:94240"
                     /db_xref="HGNC:HGNC:16465"
                     /db_xref="MIM:607441"
ORIGIN      
        1 mqskykqklk reesvrikke aeeaelqkmk aiqreksnkl eekkrlqenl rreafrehqq
       61 yktaeflskl ntespdrsac qsavcgpqss twklpilprd hswarswayr dslkaeenrk
      121 lqkmkdeqhq ksellelkrq qqeqerakih qtehrrvnna fldrlqgksq pggleqsggc
      181 wnmnsgnswg sllvfsrhlr vyekiltpiw psstdlekph emlflnvilf sltvftlist
      241 ahtldravrs dwlllvliya cleelipeli fnlycqgnat lff
//
LOCUS       XP_011533615             283 aa            linear   PRI 05-AUG-2025
DEFINITION  epithelial-stromal interaction protein 1 isoform X3 [Homo sapiens].
ACCESSION   XP_011533615
VERSION     XP_011533615.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535313.2
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 21% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..283
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..283
                     /product="epithelial-stromal interaction protein 1 isoform
                     X3"
                     /calculated_mol_wt=33170
     Region          <7..157
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     CDS             1..283
                     /gene="EPSTI1"
                     /gene_synonym="BRESI1"
                     /coded_by="XM_011535313.2:399..1250"
                     /db_xref="GeneID:94240"
                     /db_xref="HGNC:HGNC:16465"
                     /db_xref="MIM:607441"
ORIGIN      
        1 mqskykqklk reesvrikke aeeaelqkmk aiqreksnkl eekkrlqenl rreafrehqq
       61 yktaeflskl ntespdrsac qsavcgpqss twklpilprd hswarswayr dslkaeenrk
      121 lqkmkdeqhq ksellelkrq qqeqerakih qtehrrvnna fldrlqgksq pggleqsggc
      181 wnmnsgnswg sllvfsrhlr vyekiltpiw psstdlekph emlflnvilf sltvftlist
      241 ahtldravrs dwlllvliya cleelipeli fnlycqgnat lff
//
LOCUS       XP_011533616             228 aa            linear   PRI 05-AUG-2025
DEFINITION  epithelial-stromal interaction protein 1 isoform X4 [Homo sapiens].
ACCESSION   XP_011533616
VERSION     XP_011533616.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535314.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..228
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..228
                     /product="epithelial-stromal interaction protein 1 isoform
                     X4"
                     /calculated_mol_wt=26314
     Region          <53..202
                     /region_name="cdk7"
                     /note="CDK-activating kinase assembly factor MAT1;
                     TIGR00570"
                     /db_xref="CDD:129661"
     CDS             1..228
                     /gene="EPSTI1"
                     /gene_synonym="BRESI1"
                     /coded_by="XM_011535314.2:5577..6263"
                     /db_xref="GeneID:94240"
                     /db_xref="HGNC:HGNC:16465"
                     /db_xref="MIM:607441"
ORIGIN      
        1 mflrvlktae flsklntesp drsacqsavc gpqsstwklp ilprdhswar swayrdslka
       61 eenrklqkmk deqhqksell elkrqqqeqe rakihqtehr rvnnafldrl qgksqpggle
      121 qsggcwnmns gnswgsllvf srhlrvyeki ltpiwpsstd lekphemlfl nvilfsltvf
      181 tlistahtld ravrsdwlll vliyacleel ipelifnlyc qgnatlff
//
LOCUS       XP_047286740             180 aa            linear   PRI 05-AUG-2025
DEFINITION  epithelial-stromal interaction protein 1 isoform X5 [Homo sapiens].
ACCESSION   XP_047286740
VERSION     XP_047286740.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430784.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 46% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..180
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..180
                     /product="epithelial-stromal interaction protein 1 isoform
                     X5"
                     /calculated_mol_wt=21130
     CDS             1..180
                     /gene="EPSTI1"
                     /gene_synonym="BRESI1"
                     /coded_by="XM_047430784.1:542..1084"
                     /db_xref="GeneID:94240"
                     /db_xref="HGNC:HGNC:16465"
                     /db_xref="MIM:607441"
ORIGIN      
        1 mqskykqklk reesvrikke aeeaelqkmk aiqreksnkl eekkrlqenl rreafrehqq
       61 yktaeflskl ntespdrsac qsavcgpqss twarswayrd slkaeenrkl qkmkdeqhqk
      121 sellelkrqq qeqerakihq tehrrvnnaf ldrlqgksqp ggleqsggcw nmnsgnswgi
//
LOCUS       XP_011533617             497 aa            linear   PRI 05-AUG-2025
DEFINITION  peptide chain release factor 1, mitochondrial isoform X1 [Homo
            sapiens].
ACCESSION   XP_011533617
VERSION     XP_011533617.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535315.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..497
                     /product="peptide chain release factor 1, mitochondrial
                     isoform X1"
                     /calculated_mol_wt=57416
     Region          131..488
                     /region_name="PrfA"
                     /note="Protein chain release factor RF1 [Translation,
                     ribosomal structure and biogenesis]; COG0216"
                     /db_xref="CDD:439986"
     CDS             1..497
                     /gene="MTRF1"
                     /gene_synonym="MRF1; MTTRF1; RF1"
                     /coded_by="XM_011535315.3:420..1913"
                     /db_xref="GeneID:9617"
                     /db_xref="HGNC:HGNC:7469"
                     /db_xref="MIM:604601"
ORIGIN      
        1 mgngevvlfs accfvahagc sgaisvhcnl rlpgssdypa sasraarttd aemnrhlcvw
       61 lfrhpslngy lqchiqlhsh qfrqihldtr lqvfrqnrnc ilhllsknws rrychqdtkm
      121 lwkhkalqky menlskeyqt leqclqhipv neenrrslnr rhaelaplaa iyqeiqeteq
      181 aieelesmck slnkqdekql qelaleerqt idqkinmlyn elfqslvpke kydkndvile
      241 vtagrttggd icqqftreif dmyqnyscyk hwqfellnyt padygglhha aarisgdgvy
      301 khlkyeggih rvqripevgl ssrmqrihtg tmsvivlpqp devdvkldpk dlridtfrak
      361 gaggqhvnkt dsavrlvhip tglvvecqqe rsqiknkeia frvlrarlyq qiiekdkrqq
      421 qsarklqvgt raqserirty nftqdrvsdh riayevrdik eflcggkgld qliqrllqsa
      481 deeaiaelld ehlksak
//
LOCUS       XP_047286741             497 aa            linear   PRI 05-AUG-2025
DEFINITION  peptide chain release factor 1, mitochondrial isoform X1 [Homo
            sapiens].
ACCESSION   XP_047286741
VERSION     XP_047286741.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430785.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..497
                     /product="peptide chain release factor 1, mitochondrial
                     isoform X1"
                     /calculated_mol_wt=57416
     Region          131..488
                     /region_name="PrfA"
                     /note="Protein chain release factor RF1 [Translation,
                     ribosomal structure and biogenesis]; COG0216"
                     /db_xref="CDD:439986"
     CDS             1..497
                     /gene="MTRF1"
                     /gene_synonym="MRF1; MTTRF1; RF1"
                     /coded_by="XM_047430785.1:864..2357"
                     /db_xref="GeneID:9617"
                     /db_xref="HGNC:HGNC:7469"
                     /db_xref="MIM:604601"
ORIGIN      
        1 mgngevvlfs accfvahagc sgaisvhcnl rlpgssdypa sasraarttd aemnrhlcvw
       61 lfrhpslngy lqchiqlhsh qfrqihldtr lqvfrqnrnc ilhllsknws rrychqdtkm
      121 lwkhkalqky menlskeyqt leqclqhipv neenrrslnr rhaelaplaa iyqeiqeteq
      181 aieelesmck slnkqdekql qelaleerqt idqkinmlyn elfqslvpke kydkndvile
      241 vtagrttggd icqqftreif dmyqnyscyk hwqfellnyt padygglhha aarisgdgvy
      301 khlkyeggih rvqripevgl ssrmqrihtg tmsvivlpqp devdvkldpk dlridtfrak
      361 gaggqhvnkt dsavrlvhip tglvvecqqe rsqiknkeia frvlrarlyq qiiekdkrqq
      421 qsarklqvgt raqserirty nftqdrvsdh riayevrdik eflcggkgld qliqrllqsa
      481 deeaiaelld ehlksak
//
LOCUS       XP_016876348             496 aa            linear   PRI 05-AUG-2025
DEFINITION  peptide chain release factor 1, mitochondrial isoform X2 [Homo
            sapiens].
ACCESSION   XP_016876348
VERSION     XP_016876348.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020859.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..496
                     /product="peptide chain release factor 1, mitochondrial
                     isoform X2"
                     /calculated_mol_wt=57089
     Region          131..452
                     /region_name="PrfA"
                     /note="Protein chain release factor RF1 [Translation,
                     ribosomal structure and biogenesis]; COG0216"
                     /db_xref="CDD:439986"
     CDS             1..496
                     /gene="MTRF1"
                     /gene_synonym="MRF1; MTTRF1; RF1"
                     /coded_by="XM_017020859.3:272..1762"
                     /db_xref="GeneID:9617"
                     /db_xref="HGNC:HGNC:7469"
                     /db_xref="MIM:604601"
ORIGIN      
        1 mgngevvlfs accfvahagc sgaisvhcnl rlpgssdypa sasraarttd aemnrhlcvw
       61 lfrhpslngy lqchiqlhsh qfrqihldtr lqvfrqnrnc ilhllsknws rrychqdtkm
      121 lwkhkalqky menlskeyqt leqclqhipv neenrrslnr rhaelaplaa iyqeiqeteq
      181 aieelesmck slnkqdekql qelaleerqt idqkinmlyn elfqslvpke kydkndvile
      241 vtagrttggd icqqftreif dmyqnyscyk hwqfellnyt padygglhha aarisgdgvy
      301 khlkyeggih rvqripevgl ssrmqrihtg tmsvivlpqp devdvkldpk dlridtfrak
      361 gaggqhvnkt dsavrlvhip tglvvecqqe rsqiknkeia frvlrarlyq qiiekdkrqq
      421 qsarklqvgt raqserirty nftqdrvsdh riayevrdik aqshstggsr dpahstflsl
      481 dsvrspgili mtssvr
//
LOCUS       XP_047286743             458 aa            linear   PRI 05-AUG-2025
DEFINITION  peptide chain release factor 1, mitochondrial isoform X3 [Homo
            sapiens].
ACCESSION   XP_047286743
VERSION     XP_047286743.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430787.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..458
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..458
                     /product="peptide chain release factor 1, mitochondrial
                     isoform X3"
                     /calculated_mol_wt=53524
     Region          92..449
                     /region_name="PrfA"
                     /note="Protein chain release factor RF1 [Translation,
                     ribosomal structure and biogenesis]; COG0216"
                     /db_xref="CDD:439986"
     CDS             1..458
                     /gene="MTRF1"
                     /gene_synonym="MRF1; MTTRF1; RF1"
                     /coded_by="XM_047430787.1:272..1648"
                     /db_xref="GeneID:9617"
                     /db_xref="HGNC:HGNC:7469"
                     /db_xref="MIM:604601"
ORIGIN      
        1 mgngevvlfs daemnrhlcv wlfrhpslng ylqchiqlhs hqfrqihldt rlqvfrqnrn
       61 cilhllsknw srrychqdtk mlwkhkalqk ymenlskeyq tleqclqhip vneenrrsln
      121 rrhaelapla aiyqeiqete qaieelesmc kslnkqdekq lqelaleerq tidqkinmly
      181 nelfqslvpk ekydkndvil evtagrttgg dicqqftrei fdmyqnyscy khwqfellny
      241 tpadygglhh aaarisgdgv ykhlkyeggi hrvqripevg lssrmqriht gtmsvivlpq
      301 pdevdvkldp kdlridtfra kgaggqhvnk tdsavrlvhi ptglvvecqq ersqiknkei
      361 afrvlrarly qqiiekdkrq qqsarklqvg traqserirt ynftqdrvsd hriayevrdi
      421 keflcggkgl dqliqrllqs adeeaiaell dehlksak
//
LOCUS       XP_011533619             458 aa            linear   PRI 05-AUG-2025
DEFINITION  peptide chain release factor 1, mitochondrial isoform X3 [Homo
            sapiens].
ACCESSION   XP_011533619
VERSION     XP_011533619.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535317.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..458
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..458
                     /product="peptide chain release factor 1, mitochondrial
                     isoform X3"
                     /calculated_mol_wt=53524
     Region          92..449
                     /region_name="PrfA"
                     /note="Protein chain release factor RF1 [Translation,
                     ribosomal structure and biogenesis]; COG0216"
                     /db_xref="CDD:439986"
     CDS             1..458
                     /gene="MTRF1"
                     /gene_synonym="MRF1; MTTRF1; RF1"
                     /coded_by="XM_011535317.3:420..1796"
                     /db_xref="GeneID:9617"
                     /db_xref="HGNC:HGNC:7469"
                     /db_xref="MIM:604601"
ORIGIN      
        1 mgngevvlfs daemnrhlcv wlfrhpslng ylqchiqlhs hqfrqihldt rlqvfrqnrn
       61 cilhllsknw srrychqdtk mlwkhkalqk ymenlskeyq tleqclqhip vneenrrsln
      121 rrhaelapla aiyqeiqete qaieelesmc kslnkqdekq lqelaleerq tidqkinmly
      181 nelfqslvpk ekydkndvil evtagrttgg dicqqftrei fdmyqnyscy khwqfellny
      241 tpadygglhh aaarisgdgv ykhlkyeggi hrvqripevg lssrmqriht gtmsvivlpq
      301 pdevdvkldp kdlridtfra kgaggqhvnk tdsavrlvhi ptglvvecqq ersqiknkei
      361 afrvlrarly qqiiekdkrq qqsarklqvg traqserirt ynftqdrvsd hriayevrdi
      421 keflcggkgl dqliqrllqs adeeaiaell dehlksak
//
LOCUS       XP_047286744             457 aa            linear   PRI 05-AUG-2025
DEFINITION  peptide chain release factor 1, mitochondrial isoform X4 [Homo
            sapiens].
ACCESSION   XP_047286744
VERSION     XP_047286744.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430788.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..457
                     /product="peptide chain release factor 1, mitochondrial
                     isoform X4"
                     /calculated_mol_wt=53198
     Region          92..413
                     /region_name="PrfA"
                     /note="Protein chain release factor RF1 [Translation,
                     ribosomal structure and biogenesis]; COG0216"
                     /db_xref="CDD:439986"
     CDS             1..457
                     /gene="MTRF1"
                     /gene_synonym="MRF1; MTTRF1; RF1"
                     /coded_by="XM_047430788.1:272..1645"
                     /db_xref="GeneID:9617"
                     /db_xref="HGNC:HGNC:7469"
                     /db_xref="MIM:604601"
ORIGIN      
        1 mgngevvlfs daemnrhlcv wlfrhpslng ylqchiqlhs hqfrqihldt rlqvfrqnrn
       61 cilhllsknw srrychqdtk mlwkhkalqk ymenlskeyq tleqclqhip vneenrrsln
      121 rrhaelapla aiyqeiqete qaieelesmc kslnkqdekq lqelaleerq tidqkinmly
      181 nelfqslvpk ekydkndvil evtagrttgg dicqqftrei fdmyqnyscy khwqfellny
      241 tpadygglhh aaarisgdgv ykhlkyeggi hrvqripevg lssrmqriht gtmsvivlpq
      301 pdevdvkldp kdlridtfra kgaggqhvnk tdsavrlvhi ptglvvecqq ersqiknkei
      361 afrvlrarly qqiiekdkrq qqsarklqvg traqserirt ynftqdrvsd hriayevrdi
      421 kaqshstggs rdpahstfls ldsvrspgil imtssvr
//
LOCUS       XP_016876350             457 aa            linear   PRI 05-AUG-2025
DEFINITION  peptide chain release factor 1, mitochondrial isoform X4 [Homo
            sapiens].
ACCESSION   XP_016876350
VERSION     XP_016876350.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020861.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..457
                     /product="peptide chain release factor 1, mitochondrial
                     isoform X4"
                     /calculated_mol_wt=53198
     Region          92..413
                     /region_name="PrfA"
                     /note="Protein chain release factor RF1 [Translation,
                     ribosomal structure and biogenesis]; COG0216"
                     /db_xref="CDD:439986"
     CDS             1..457
                     /gene="MTRF1"
                     /gene_synonym="MRF1; MTTRF1; RF1"
                     /coded_by="XM_017020861.3:420..1793"
                     /db_xref="GeneID:9617"
                     /db_xref="HGNC:HGNC:7469"
                     /db_xref="MIM:604601"
ORIGIN      
        1 mgngevvlfs daemnrhlcv wlfrhpslng ylqchiqlhs hqfrqihldt rlqvfrqnrn
       61 cilhllsknw srrychqdtk mlwkhkalqk ymenlskeyq tleqclqhip vneenrrsln
      121 rrhaelapla aiyqeiqete qaieelesmc kslnkqdekq lqelaleerq tidqkinmly
      181 nelfqslvpk ekydkndvil evtagrttgg dicqqftrei fdmyqnyscy khwqfellny
      241 tpadygglhh aaarisgdgv ykhlkyeggi hrvqripevg lssrmqriht gtmsvivlpq
      301 pdevdvkldp kdlridtfra kgaggqhvnk tdsavrlvhi ptglvvecqq ersqiknkei
      361 afrvlrarly qqiiekdkrq qqsarklqvg traqserirt ynftqdrvsd hriayevrdi
      421 kaqshstggs rdpahstfls ldsvrspgil imtssvr
//
LOCUS       XP_047286745             445 aa            linear   PRI 05-AUG-2025
DEFINITION  peptide chain release factor 1, mitochondrial isoform X5 [Homo
            sapiens].
ACCESSION   XP_047286745
VERSION     XP_047286745.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430789.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..445
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..445
                     /product="peptide chain release factor 1, mitochondrial
                     isoform X5"
                     /calculated_mol_wt=52175
     Region          79..436
                     /region_name="PrfA"
                     /note="Protein chain release factor RF1 [Translation,
                     ribosomal structure and biogenesis]; COG0216"
                     /db_xref="CDD:439986"
     CDS             1..445
                     /gene="MTRF1"
                     /gene_synonym="MRF1; MTTRF1; RF1"
                     /coded_by="XM_047430789.1:1729..3066"
                     /db_xref="GeneID:9617"
                     /db_xref="HGNC:HGNC:7469"
                     /db_xref="MIM:604601"
ORIGIN      
        1 mnrhlcvwlf rhpslngylq chiqlhshqf rqihldtrlq vfrqnrncil hllsknwsrr
       61 ychqdtkmlw khkalqkyme nlskeyqtle qclqhipvne enrrslnrrh aelaplaaiy
      121 qeiqeteqai eelesmcksl nkqdekqlqe laleerqtid qkinmlynel fqslvpkeky
      181 dkndvilevt agrttggdic qqftreifdm yqnyscykhw qfellnytpa dygglhhaaa
      241 risgdgvykh lkyeggihrv qripevglss rmqrihtgtm svivlpqpde vdvkldpkdl
      301 ridtfrakga ggqhvnktds avrlvhiptg lvvecqqers qiknkeiafr vlrarlyqqi
      361 iekdkrqqqs arklqvgtra qserirtynf tqdrvsdhri ayevrdikef lcggkgldql
      421 iqrllqsade eaiaelldeh lksak
//
LOCUS       XP_024305208             445 aa            linear   PRI 05-AUG-2025
DEFINITION  peptide chain release factor 1, mitochondrial isoform X5 [Homo
            sapiens].
ACCESSION   XP_024305208
VERSION     XP_024305208.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449440.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..445
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..445
                     /product="peptide chain release factor 1, mitochondrial
                     isoform X5"
                     /calculated_mol_wt=52175
     Region          79..436
                     /region_name="PrfA"
                     /note="Protein chain release factor RF1 [Translation,
                     ribosomal structure and biogenesis]; COG0216"
                     /db_xref="CDD:439986"
     CDS             1..445
                     /gene="MTRF1"
                     /gene_synonym="MRF1; MTTRF1; RF1"
                     /coded_by="XM_024449440.2:2281..3618"
                     /db_xref="GeneID:9617"
                     /db_xref="HGNC:HGNC:7469"
                     /db_xref="MIM:604601"
ORIGIN      
        1 mnrhlcvwlf rhpslngylq chiqlhshqf rqihldtrlq vfrqnrncil hllsknwsrr
       61 ychqdtkmlw khkalqkyme nlskeyqtle qclqhipvne enrrslnrrh aelaplaaiy
      121 qeiqeteqai eelesmcksl nkqdekqlqe laleerqtid qkinmlynel fqslvpkeky
      181 dkndvilevt agrttggdic qqftreifdm yqnyscykhw qfellnytpa dygglhhaaa
      241 risgdgvykh lkyeggihrv qripevglss rmqrihtgtm svivlpqpde vdvkldpkdl
      301 ridtfrakga ggqhvnktds avrlvhiptg lvvecqqers qiknkeiafr vlrarlyqqi
      361 iekdkrqqqs arklqvgtra qserirtynf tqdrvsdhri ayevrdikef lcggkgldql
      421 iqrllqsade eaiaelldeh lksak
//
LOCUS       XP_024305209             445 aa            linear   PRI 05-AUG-2025
DEFINITION  peptide chain release factor 1, mitochondrial isoform X5 [Homo
            sapiens].
ACCESSION   XP_024305209
VERSION     XP_024305209.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449441.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..445
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..445
                     /product="peptide chain release factor 1, mitochondrial
                     isoform X5"
                     /calculated_mol_wt=52175
     Region          79..436
                     /region_name="PrfA"
                     /note="Protein chain release factor RF1 [Translation,
                     ribosomal structure and biogenesis]; COG0216"
                     /db_xref="CDD:439986"
     CDS             1..445
                     /gene="MTRF1"
                     /gene_synonym="MRF1; MTTRF1; RF1"
                     /coded_by="XM_024449441.2:1294..2631"
                     /db_xref="GeneID:9617"
                     /db_xref="HGNC:HGNC:7469"
                     /db_xref="MIM:604601"
ORIGIN      
        1 mnrhlcvwlf rhpslngylq chiqlhshqf rqihldtrlq vfrqnrncil hllsknwsrr
       61 ychqdtkmlw khkalqkyme nlskeyqtle qclqhipvne enrrslnrrh aelaplaaiy
      121 qeiqeteqai eelesmcksl nkqdekqlqe laleerqtid qkinmlynel fqslvpkeky
      181 dkndvilevt agrttggdic qqftreifdm yqnyscykhw qfellnytpa dygglhhaaa
      241 risgdgvykh lkyeggihrv qripevglss rmqrihtgtm svivlpqpde vdvkldpkdl
      301 ridtfrakga ggqhvnktds avrlvhiptg lvvecqqers qiknkeiafr vlrarlyqqi
      361 iekdkrqqqs arklqvgtra qserirtynf tqdrvsdhri ayevrdikef lcggkgldql
      421 iqrllqsade eaiaelldeh lksak
//
LOCUS       XP_047286746             445 aa            linear   PRI 05-AUG-2025
DEFINITION  peptide chain release factor 1, mitochondrial isoform X5 [Homo
            sapiens].
ACCESSION   XP_047286746
VERSION     XP_047286746.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430790.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..445
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..445
                     /product="peptide chain release factor 1, mitochondrial
                     isoform X5"
                     /calculated_mol_wt=52175
     Region          79..436
                     /region_name="PrfA"
                     /note="Protein chain release factor RF1 [Translation,
                     ribosomal structure and biogenesis]; COG0216"
                     /db_xref="CDD:439986"
     CDS             1..445
                     /gene="MTRF1"
                     /gene_synonym="MRF1; MTTRF1; RF1"
                     /coded_by="XM_047430790.1:1358..2695"
                     /db_xref="GeneID:9617"
                     /db_xref="HGNC:HGNC:7469"
                     /db_xref="MIM:604601"
ORIGIN      
        1 mnrhlcvwlf rhpslngylq chiqlhshqf rqihldtrlq vfrqnrncil hllsknwsrr
       61 ychqdtkmlw khkalqkyme nlskeyqtle qclqhipvne enrrslnrrh aelaplaaiy
      121 qeiqeteqai eelesmcksl nkqdekqlqe laleerqtid qkinmlynel fqslvpkeky
      181 dkndvilevt agrttggdic qqftreifdm yqnyscykhw qfellnytpa dygglhhaaa
      241 risgdgvykh lkyeggihrv qripevglss rmqrihtgtm svivlpqpde vdvkldpkdl
      301 ridtfrakga ggqhvnktds avrlvhiptg lvvecqqers qiknkeiafr vlrarlyqqi
      361 iekdkrqqqs arklqvgtra qserirtynf tqdrvsdhri ayevrdikef lcggkgldql
      421 iqrllqsade eaiaelldeh lksak
//
LOCUS       XP_047286747             445 aa            linear   PRI 05-AUG-2025
DEFINITION  peptide chain release factor 1, mitochondrial isoform X5 [Homo
            sapiens].
ACCESSION   XP_047286747
VERSION     XP_047286747.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430791.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..445
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..445
                     /product="peptide chain release factor 1, mitochondrial
                     isoform X5"
                     /calculated_mol_wt=52175
     Region          79..436
                     /region_name="PrfA"
                     /note="Protein chain release factor RF1 [Translation,
                     ribosomal structure and biogenesis]; COG0216"
                     /db_xref="CDD:439986"
     CDS             1..445
                     /gene="MTRF1"
                     /gene_synonym="MRF1; MTTRF1; RF1"
                     /coded_by="XM_047430791.1:1187..2524"
                     /db_xref="GeneID:9617"
                     /db_xref="HGNC:HGNC:7469"
                     /db_xref="MIM:604601"
ORIGIN      
        1 mnrhlcvwlf rhpslngylq chiqlhshqf rqihldtrlq vfrqnrncil hllsknwsrr
       61 ychqdtkmlw khkalqkyme nlskeyqtle qclqhipvne enrrslnrrh aelaplaaiy
      121 qeiqeteqai eelesmcksl nkqdekqlqe laleerqtid qkinmlynel fqslvpkeky
      181 dkndvilevt agrttggdic qqftreifdm yqnyscykhw qfellnytpa dygglhhaaa
      241 risgdgvykh lkyeggihrv qripevglss rmqrihtgtm svivlpqpde vdvkldpkdl
      301 ridtfrakga ggqhvnktds avrlvhiptg lvvecqqers qiknkeiafr vlrarlyqqi
      361 iekdkrqqqs arklqvgtra qserirtynf tqdrvsdhri ayevrdikef lcggkgldql
      421 iqrllqsade eaiaelldeh lksak
//
LOCUS       XP_047286748             445 aa            linear   PRI 05-AUG-2025
DEFINITION  peptide chain release factor 1, mitochondrial isoform X5 [Homo
            sapiens].
ACCESSION   XP_047286748
VERSION     XP_047286748.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430792.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..445
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..445
                     /product="peptide chain release factor 1, mitochondrial
                     isoform X5"
                     /calculated_mol_wt=52175
     Region          79..436
                     /region_name="PrfA"
                     /note="Protein chain release factor RF1 [Translation,
                     ribosomal structure and biogenesis]; COG0216"
                     /db_xref="CDD:439986"
     CDS             1..445
                     /gene="MTRF1"
                     /gene_synonym="MRF1; MTTRF1; RF1"
                     /coded_by="XM_047430792.1:1618..2955"
                     /db_xref="GeneID:9617"
                     /db_xref="HGNC:HGNC:7469"
                     /db_xref="MIM:604601"
ORIGIN      
        1 mnrhlcvwlf rhpslngylq chiqlhshqf rqihldtrlq vfrqnrncil hllsknwsrr
       61 ychqdtkmlw khkalqkyme nlskeyqtle qclqhipvne enrrslnrrh aelaplaaiy
      121 qeiqeteqai eelesmcksl nkqdekqlqe laleerqtid qkinmlynel fqslvpkeky
      181 dkndvilevt agrttggdic qqftreifdm yqnyscykhw qfellnytpa dygglhhaaa
      241 risgdgvykh lkyeggihrv qripevglss rmqrihtgtm svivlpqpde vdvkldpkdl
      301 ridtfrakga ggqhvnktds avrlvhiptg lvvecqqers qiknkeiafr vlrarlyqqi
      361 iekdkrqqqs arklqvgtra qserirtynf tqdrvsdhri ayevrdikef lcggkgldql
      421 iqrllqsade eaiaelldeh lksak
//
LOCUS       XP_047286749             445 aa            linear   PRI 05-AUG-2025
DEFINITION  peptide chain release factor 1, mitochondrial isoform X5 [Homo
            sapiens].
ACCESSION   XP_047286749
VERSION     XP_047286749.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430793.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..445
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..445
                     /product="peptide chain release factor 1, mitochondrial
                     isoform X5"
                     /calculated_mol_wt=52175
     Region          79..436
                     /region_name="PrfA"
                     /note="Protein chain release factor RF1 [Translation,
                     ribosomal structure and biogenesis]; COG0216"
                     /db_xref="CDD:439986"
     CDS             1..445
                     /gene="MTRF1"
                     /gene_synonym="MRF1; MTTRF1; RF1"
                     /coded_by="XM_047430793.1:1466..2803"
                     /db_xref="GeneID:9617"
                     /db_xref="HGNC:HGNC:7469"
                     /db_xref="MIM:604601"
ORIGIN      
        1 mnrhlcvwlf rhpslngylq chiqlhshqf rqihldtrlq vfrqnrncil hllsknwsrr
       61 ychqdtkmlw khkalqkyme nlskeyqtle qclqhipvne enrrslnrrh aelaplaaiy
      121 qeiqeteqai eelesmcksl nkqdekqlqe laleerqtid qkinmlynel fqslvpkeky
      181 dkndvilevt agrttggdic qqftreifdm yqnyscykhw qfellnytpa dygglhhaaa
      241 risgdgvykh lkyeggihrv qripevglss rmqrihtgtm svivlpqpde vdvkldpkdl
      301 ridtfrakga ggqhvnktds avrlvhiptg lvvecqqers qiknkeiafr vlrarlyqqi
      361 iekdkrqqqs arklqvgtra qserirtynf tqdrvsdhri ayevrdikef lcggkgldql
      421 iqrllqsade eaiaelldeh lksak
//
LOCUS       XP_047286750             445 aa            linear   PRI 05-AUG-2025
DEFINITION  peptide chain release factor 1, mitochondrial isoform X5 [Homo
            sapiens].
ACCESSION   XP_047286750
VERSION     XP_047286750.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430794.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..445
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..445
                     /product="peptide chain release factor 1, mitochondrial
                     isoform X5"
                     /calculated_mol_wt=52175
     Region          79..436
                     /region_name="PrfA"
                     /note="Protein chain release factor RF1 [Translation,
                     ribosomal structure and biogenesis]; COG0216"
                     /db_xref="CDD:439986"
     CDS             1..445
                     /gene="MTRF1"
                     /gene_synonym="MRF1; MTTRF1; RF1"
                     /coded_by="XM_047430794.1:1626..2963"
                     /db_xref="GeneID:9617"
                     /db_xref="HGNC:HGNC:7469"
                     /db_xref="MIM:604601"
ORIGIN      
        1 mnrhlcvwlf rhpslngylq chiqlhshqf rqihldtrlq vfrqnrncil hllsknwsrr
       61 ychqdtkmlw khkalqkyme nlskeyqtle qclqhipvne enrrslnrrh aelaplaaiy
      121 qeiqeteqai eelesmcksl nkqdekqlqe laleerqtid qkinmlynel fqslvpkeky
      181 dkndvilevt agrttggdic qqftreifdm yqnyscykhw qfellnytpa dygglhhaaa
      241 risgdgvykh lkyeggihrv qripevglss rmqrihtgtm svivlpqpde vdvkldpkdl
      301 ridtfrakga ggqhvnktds avrlvhiptg lvvecqqers qiknkeiafr vlrarlyqqi
      361 iekdkrqqqs arklqvgtra qserirtynf tqdrvsdhri ayevrdikef lcggkgldql
      421 iqrllqsade eaiaelldeh lksak
//
LOCUS       XP_047286751             445 aa            linear   PRI 05-AUG-2025
DEFINITION  peptide chain release factor 1, mitochondrial isoform X5 [Homo
            sapiens].
ACCESSION   XP_047286751
VERSION     XP_047286751.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430795.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..445
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..445
                     /product="peptide chain release factor 1, mitochondrial
                     isoform X5"
                     /calculated_mol_wt=52175
     Region          79..436
                     /region_name="PrfA"
                     /note="Protein chain release factor RF1 [Translation,
                     ribosomal structure and biogenesis]; COG0216"
                     /db_xref="CDD:439986"
     CDS             1..445
                     /gene="MTRF1"
                     /gene_synonym="MRF1; MTTRF1; RF1"
                     /coded_by="XM_047430795.1:1342..2679"
                     /db_xref="GeneID:9617"
                     /db_xref="HGNC:HGNC:7469"
                     /db_xref="MIM:604601"
ORIGIN      
        1 mnrhlcvwlf rhpslngylq chiqlhshqf rqihldtrlq vfrqnrncil hllsknwsrr
       61 ychqdtkmlw khkalqkyme nlskeyqtle qclqhipvne enrrslnrrh aelaplaaiy
      121 qeiqeteqai eelesmcksl nkqdekqlqe laleerqtid qkinmlynel fqslvpkeky
      181 dkndvilevt agrttggdic qqftreifdm yqnyscykhw qfellnytpa dygglhhaaa
      241 risgdgvykh lkyeggihrv qripevglss rmqrihtgtm svivlpqpde vdvkldpkdl
      301 ridtfrakga ggqhvnktds avrlvhiptg lvvecqqers qiknkeiafr vlrarlyqqi
      361 iekdkrqqqs arklqvgtra qserirtynf tqdrvsdhri ayevrdikef lcggkgldql
      421 iqrllqsade eaiaelldeh lksak
//
LOCUS       XP_047286752             445 aa            linear   PRI 05-AUG-2025
DEFINITION  peptide chain release factor 1, mitochondrial isoform X5 [Homo
            sapiens].
ACCESSION   XP_047286752
VERSION     XP_047286752.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430796.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..445
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..445
                     /product="peptide chain release factor 1, mitochondrial
                     isoform X5"
                     /calculated_mol_wt=52175
     Region          79..436
                     /region_name="PrfA"
                     /note="Protein chain release factor RF1 [Translation,
                     ribosomal structure and biogenesis]; COG0216"
                     /db_xref="CDD:439986"
     CDS             1..445
                     /gene="MTRF1"
                     /gene_synonym="MRF1; MTTRF1; RF1"
                     /coded_by="XM_047430796.1:1340..2677"
                     /db_xref="GeneID:9617"
                     /db_xref="HGNC:HGNC:7469"
                     /db_xref="MIM:604601"
ORIGIN      
        1 mnrhlcvwlf rhpslngylq chiqlhshqf rqihldtrlq vfrqnrncil hllsknwsrr
       61 ychqdtkmlw khkalqkyme nlskeyqtle qclqhipvne enrrslnrrh aelaplaaiy
      121 qeiqeteqai eelesmcksl nkqdekqlqe laleerqtid qkinmlynel fqslvpkeky
      181 dkndvilevt agrttggdic qqftreifdm yqnyscykhw qfellnytpa dygglhhaaa
      241 risgdgvykh lkyeggihrv qripevglss rmqrihtgtm svivlpqpde vdvkldpkdl
      301 ridtfrakga ggqhvnktds avrlvhiptg lvvecqqers qiknkeiafr vlrarlyqqi
      361 iekdkrqqqs arklqvgtra qserirtynf tqdrvsdhri ayevrdikef lcggkgldql
      421 iqrllqsade eaiaelldeh lksak
//
LOCUS       XP_047286753             445 aa            linear   PRI 05-AUG-2025
DEFINITION  peptide chain release factor 1, mitochondrial isoform X5 [Homo
            sapiens].
ACCESSION   XP_047286753
VERSION     XP_047286753.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430797.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..445
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..445
                     /product="peptide chain release factor 1, mitochondrial
                     isoform X5"
                     /calculated_mol_wt=52175
     Region          79..436
                     /region_name="PrfA"
                     /note="Protein chain release factor RF1 [Translation,
                     ribosomal structure and biogenesis]; COG0216"
                     /db_xref="CDD:439986"
     CDS             1..445
                     /gene="MTRF1"
                     /gene_synonym="MRF1; MTTRF1; RF1"
                     /coded_by="XM_047430797.1:1223..2560"
                     /db_xref="GeneID:9617"
                     /db_xref="HGNC:HGNC:7469"
                     /db_xref="MIM:604601"
ORIGIN      
        1 mnrhlcvwlf rhpslngylq chiqlhshqf rqihldtrlq vfrqnrncil hllsknwsrr
       61 ychqdtkmlw khkalqkyme nlskeyqtle qclqhipvne enrrslnrrh aelaplaaiy
      121 qeiqeteqai eelesmcksl nkqdekqlqe laleerqtid qkinmlynel fqslvpkeky
      181 dkndvilevt agrttggdic qqftreifdm yqnyscykhw qfellnytpa dygglhhaaa
      241 risgdgvykh lkyeggihrv qripevglss rmqrihtgtm svivlpqpde vdvkldpkdl
      301 ridtfrakga ggqhvnktds avrlvhiptg lvvecqqers qiknkeiafr vlrarlyqqi
      361 iekdkrqqqs arklqvgtra qserirtynf tqdrvsdhri ayevrdikef lcggkgldql
      421 iqrllqsade eaiaelldeh lksak
//
LOCUS       XP_016876355             445 aa            linear   PRI 05-AUG-2025
DEFINITION  peptide chain release factor 1, mitochondrial isoform X5 [Homo
            sapiens].
ACCESSION   XP_016876355
VERSION     XP_016876355.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020866.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..445
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..445
                     /product="peptide chain release factor 1, mitochondrial
                     isoform X5"
                     /calculated_mol_wt=52175
     Region          79..436
                     /region_name="PrfA"
                     /note="Protein chain release factor RF1 [Translation,
                     ribosomal structure and biogenesis]; COG0216"
                     /db_xref="CDD:439986"
     CDS             1..445
                     /gene="MTRF1"
                     /gene_synonym="MRF1; MTTRF1; RF1"
                     /coded_by="XM_017020866.3:1175..2512"
                     /db_xref="GeneID:9617"
                     /db_xref="HGNC:HGNC:7469"
                     /db_xref="MIM:604601"
ORIGIN      
        1 mnrhlcvwlf rhpslngylq chiqlhshqf rqihldtrlq vfrqnrncil hllsknwsrr
       61 ychqdtkmlw khkalqkyme nlskeyqtle qclqhipvne enrrslnrrh aelaplaaiy
      121 qeiqeteqai eelesmcksl nkqdekqlqe laleerqtid qkinmlynel fqslvpkeky
      181 dkndvilevt agrttggdic qqftreifdm yqnyscykhw qfellnytpa dygglhhaaa
      241 risgdgvykh lkyeggihrv qripevglss rmqrihtgtm svivlpqpde vdvkldpkdl
      301 ridtfrakga ggqhvnktds avrlvhiptg lvvecqqers qiknkeiafr vlrarlyqqi
      361 iekdkrqqqs arklqvgtra qserirtynf tqdrvsdhri ayevrdikef lcggkgldql
      421 iqrllqsade eaiaelldeh lksak
//
LOCUS       XP_024305210             445 aa            linear   PRI 05-AUG-2025
DEFINITION  peptide chain release factor 1, mitochondrial isoform X5 [Homo
            sapiens].
ACCESSION   XP_024305210
VERSION     XP_024305210.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449442.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..445
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..445
                     /product="peptide chain release factor 1, mitochondrial
                     isoform X5"
                     /calculated_mol_wt=52175
     Region          79..436
                     /region_name="PrfA"
                     /note="Protein chain release factor RF1 [Translation,
                     ribosomal structure and biogenesis]; COG0216"
                     /db_xref="CDD:439986"
     CDS             1..445
                     /gene="MTRF1"
                     /gene_synonym="MRF1; MTTRF1; RF1"
                     /coded_by="XM_024449442.2:1116..2453"
                     /db_xref="GeneID:9617"
                     /db_xref="HGNC:HGNC:7469"
                     /db_xref="MIM:604601"
ORIGIN      
        1 mnrhlcvwlf rhpslngylq chiqlhshqf rqihldtrlq vfrqnrncil hllsknwsrr
       61 ychqdtkmlw khkalqkyme nlskeyqtle qclqhipvne enrrslnrrh aelaplaaiy
      121 qeiqeteqai eelesmcksl nkqdekqlqe laleerqtid qkinmlynel fqslvpkeky
      181 dkndvilevt agrttggdic qqftreifdm yqnyscykhw qfellnytpa dygglhhaaa
      241 risgdgvykh lkyeggihrv qripevglss rmqrihtgtm svivlpqpde vdvkldpkdl
      301 ridtfrakga ggqhvnktds avrlvhiptg lvvecqqers qiknkeiafr vlrarlyqqi
      361 iekdkrqqqs arklqvgtra qserirtynf tqdrvsdhri ayevrdikef lcggkgldql
      421 iqrllqsade eaiaelldeh lksak
//
LOCUS       XP_047286754             445 aa            linear   PRI 05-AUG-2025
DEFINITION  peptide chain release factor 1, mitochondrial isoform X5 [Homo
            sapiens].
ACCESSION   XP_047286754
VERSION     XP_047286754.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430798.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..445
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..445
                     /product="peptide chain release factor 1, mitochondrial
                     isoform X5"
                     /calculated_mol_wt=52175
     Region          79..436
                     /region_name="PrfA"
                     /note="Protein chain release factor RF1 [Translation,
                     ribosomal structure and biogenesis]; COG0216"
                     /db_xref="CDD:439986"
     CDS             1..445
                     /gene="MTRF1"
                     /gene_synonym="MRF1; MTTRF1; RF1"
                     /coded_by="XM_047430798.1:384..1721"
                     /db_xref="GeneID:9617"
                     /db_xref="HGNC:HGNC:7469"
                     /db_xref="MIM:604601"
ORIGIN      
        1 mnrhlcvwlf rhpslngylq chiqlhshqf rqihldtrlq vfrqnrncil hllsknwsrr
       61 ychqdtkmlw khkalqkyme nlskeyqtle qclqhipvne enrrslnrrh aelaplaaiy
      121 qeiqeteqai eelesmcksl nkqdekqlqe laleerqtid qkinmlynel fqslvpkeky
      181 dkndvilevt agrttggdic qqftreifdm yqnyscykhw qfellnytpa dygglhhaaa
      241 risgdgvykh lkyeggihrv qripevglss rmqrihtgtm svivlpqpde vdvkldpkdl
      301 ridtfrakga ggqhvnktds avrlvhiptg lvvecqqers qiknkeiafr vlrarlyqqi
      361 iekdkrqqqs arklqvgtra qserirtynf tqdrvsdhri ayevrdikef lcggkgldql
      421 iqrllqsade eaiaelldeh lksak
//
LOCUS       XP_011533628             384 aa            linear   PRI 05-AUG-2025
DEFINITION  peptide chain release factor 1, mitochondrial isoform X6 [Homo
            sapiens].
ACCESSION   XP_011533628
VERSION     XP_011533628.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535326.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..384
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..384
                     /product="peptide chain release factor 1, mitochondrial
                     isoform X6"
                     /calculated_mol_wt=44124
     Region          131..>382
                     /region_name="PrfA"
                     /note="Protein chain release factor RF1 [Translation,
                     ribosomal structure and biogenesis]; COG0216"
                     /db_xref="CDD:439986"
     CDS             1..384
                     /gene="MTRF1"
                     /gene_synonym="MRF1; MTTRF1; RF1"
                     /coded_by="XM_011535326.4:272..1426"
                     /db_xref="GeneID:9617"
                     /db_xref="HGNC:HGNC:7469"
                     /db_xref="MIM:604601"
ORIGIN      
        1 mgngevvlfs accfvahagc sgaisvhcnl rlpgssdypa sasraarttd aemnrhlcvw
       61 lfrhpslngy lqchiqlhsh qfrqihldtr lqvfrqnrnc ilhllsknws rrychqdtkm
      121 lwkhkalqky menlskeyqt leqclqhipv neenrrslnr rhaelaplaa iyqeiqeteq
      181 aieelesmck slnkqdekql qelaleerqt idqkinmlyn elfqslvpke kydkndvile
      241 vtagrttggd icqqftreif dmyqnyscyk hwqfellnyt padygglhha aarisgdgvy
      301 khlkyeggih rvqripevgl ssrmqrihtg tmsvivlpqp devdvkldpk dlridtfrak
      361 gaggqhvnkt dsavrlvhip tgnc
//
LOCUS       XP_047286755             345 aa            linear   PRI 05-AUG-2025
DEFINITION  peptide chain release factor 1, mitochondrial isoform X7 [Homo
            sapiens].
ACCESSION   XP_047286755
VERSION     XP_047286755.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430799.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..345
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..345
                     /product="peptide chain release factor 1, mitochondrial
                     isoform X7"
                     /calculated_mol_wt=40233
     Region          92..>343
                     /region_name="PrfA"
                     /note="Protein chain release factor RF1 [Translation,
                     ribosomal structure and biogenesis]; COG0216"
                     /db_xref="CDD:439986"
     CDS             1..345
                     /gene="MTRF1"
                     /gene_synonym="MRF1; MTTRF1; RF1"
                     /coded_by="XM_047430799.1:420..1457"
                     /db_xref="GeneID:9617"
                     /db_xref="HGNC:HGNC:7469"
                     /db_xref="MIM:604601"
ORIGIN      
        1 mgngevvlfs daemnrhlcv wlfrhpslng ylqchiqlhs hqfrqihldt rlqvfrqnrn
       61 cilhllsknw srrychqdtk mlwkhkalqk ymenlskeyq tleqclqhip vneenrrsln
      121 rrhaelapla aiyqeiqete qaieelesmc kslnkqdekq lqelaleerq tidqkinmly
      181 nelfqslvpk ekydkndvil evtagrttgg dicqqftrei fdmyqnyscy khwqfellny
      241 tpadygglhh aaarisgdgv ykhlkyeggi hrvqripevg lssrmqriht gtmsvivlpq
      301 pdevdvkldp kdlridtfra kgaggqhvnk tdsavrlvhi ptgnc
//
LOCUS       XP_047286756             309 aa            linear   PRI 05-AUG-2025
DEFINITION  peptide chain release factor 1, mitochondrial isoform X8 [Homo
            sapiens].
ACCESSION   XP_047286756
VERSION     XP_047286756.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430800.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..309
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..309
                     /product="peptide chain release factor 1, mitochondrial
                     isoform X8"
                     /calculated_mol_wt=35927
     Region          134..>286
                     /region_name="PCRF"
                     /note="PCRF domain; pfam03462"
                     /db_xref="CDD:460929"
     CDS             1..309
                     /gene="MTRF1"
                     /gene_synonym="MRF1; MTTRF1; RF1"
                     /coded_by="XM_047430800.1:272..1201"
                     /db_xref="GeneID:9617"
                     /db_xref="HGNC:HGNC:7469"
                     /db_xref="MIM:604601"
ORIGIN      
        1 mgngevvlfs accfvahagc sgaisvhcnl rlpgssdypa sasraarttd aemnrhlcvw
       61 lfrhpslngy lqchiqlhsh qfrqihldtr lqvfrqnrnc ilhllsknws rrychqdtkm
      121 lwkhkalqky menlskeyqt leqclqhipv neenrrslnr rhaelaplaa iyqeiqeteq
      181 aieelesmck slnkqdekql qelaleerqt idqkinmlyn elfqslvpke kydkndvile
      241 vtagrttggd icqqftreif dmyqnyscyk hwqfellnyt padyggceig pqgfanryis
      301 sqrsrraac
//
LOCUS       XP_047286757             332 aa            linear   PRI 05-AUG-2025
DEFINITION  peptide chain release factor 1, mitochondrial isoform X9 [Homo
            sapiens].
ACCESSION   XP_047286757
VERSION     XP_047286757.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430801.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..332
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..332
                     /product="peptide chain release factor 1, mitochondrial
                     isoform X9"
                     /calculated_mol_wt=38883
     Region          79..>330
                     /region_name="PrfA"
                     /note="Protein chain release factor RF1 [Translation,
                     ribosomal structure and biogenesis]; COG0216"
                     /db_xref="CDD:439986"
     CDS             1..332
                     /gene="MTRF1"
                     /gene_synonym="MRF1; MTTRF1; RF1"
                     /coded_by="XM_047430801.1:1729..2727"
                     /db_xref="GeneID:9617"
                     /db_xref="HGNC:HGNC:7469"
                     /db_xref="MIM:604601"
ORIGIN      
        1 mnrhlcvwlf rhpslngylq chiqlhshqf rqihldtrlq vfrqnrncil hllsknwsrr
       61 ychqdtkmlw khkalqkyme nlskeyqtle qclqhipvne enrrslnrrh aelaplaaiy
      121 qeiqeteqai eelesmcksl nkqdekqlqe laleerqtid qkinmlynel fqslvpkeky
      181 dkndvilevt agrttggdic qqftreifdm yqnyscykhw qfellnytpa dygglhhaaa
      241 risgdgvykh lkyeggihrv qripevglss rmqrihtgtm svivlpqpde vdvkldpkdl
      301 ridtfrakga ggqhvnktds avrlvhiptg nc
//
LOCUS       XP_047286758             257 aa            linear   PRI 05-AUG-2025
DEFINITION  peptide chain release factor 1, mitochondrial isoform X10 [Homo
            sapiens].
ACCESSION   XP_047286758
VERSION     XP_047286758.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430802.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..257
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..257
                     /product="peptide chain release factor 1, mitochondrial
                     isoform X10"
                     /calculated_mol_wt=30686
     Region          82..>234
                     /region_name="PCRF"
                     /note="PCRF domain; pfam03462"
                     /db_xref="CDD:460929"
     CDS             1..257
                     /gene="MTRF1"
                     /gene_synonym="MRF1; MTTRF1; RF1"
                     /coded_by="XM_047430802.1:1729..2502"
                     /db_xref="GeneID:9617"
                     /db_xref="HGNC:HGNC:7469"
                     /db_xref="MIM:604601"
ORIGIN      
        1 mnrhlcvwlf rhpslngylq chiqlhshqf rqihldtrlq vfrqnrncil hllsknwsrr
       61 ychqdtkmlw khkalqkyme nlskeyqtle qclqhipvne enrrslnrrh aelaplaaiy
      121 qeiqeteqai eelesmcksl nkqdekqlqe laleerqtid qkinmlynel fqslvpkeky
      181 dkndvilevt agrttggdic qqftreifdm yqnyscykhw qfellnytpa dyggceigpq
      241 gfanryissq rsrraac
//
LOCUS       XP_047286760             554 aa            linear   PRI 05-AUG-2025
DEFINITION  nucleoporin p58/p45 isoform X1 [Homo sapiens].
ACCESSION   XP_047286760
VERSION     XP_047286760.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430804.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..554
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..554
                     /product="nucleoporin p58/p45 isoform X1"
                     /calculated_mol_wt=56619
     Region          3..554
                     /region_name="Nucleoporin_FG2"
                     /note="Nucleoporin FG repeated region; pfam15967"
                     /db_xref="CDD:435043"
     CDS             1..554
                     /gene="NUP58"
                     /gene_synonym="NUP45; NUPL1; PRO2463"
                     /coded_by="XM_047430804.1:150..1814"
                     /db_xref="GeneID:9818"
                     /db_xref="HGNC:HGNC:20261"
                     /db_xref="MIM:607615"
ORIGIN      
        1 mstgfsfgsg tlgsttvaag gtstggvfsf gtgassnpsv glnfgnlgst stpattsaps
       61 sgfgtglfgs kpatgftlgg tntgtpatts aattgfslgf nkpaasatpf alpitstsas
      121 gltlssalts tpaastgftl nnlggttatt ttastglslg galaglggsl fqstntgtsg
      181 lgqnalgltl gttaatstag neglggidfs sssdkksdkt gtrpedskal kdenlppvic
      241 qdvenlqkfv keqkqvqeei srmsskamlk vqedikalkq llslaangiq rntlnidklk
      301 ietaqelkna eialrtqktp pglqheyaap adyfrilvqq fevqlqqyrq qieelenhla
      361 tqannshitp qdlsmamqki yqtfvalaaq lqsihenvkv lkeqylgyrk mflgdavdvf
      421 etrraeakkw qntprvttgp tpfstmpnaa avamaatltq qqqpatgfgt ssgfgcsttg
      481 astfgfgttn kpsgslsagf gssstsgfnf snpgitasag ltfgvsnpas agfgtggqll
      541 qlkkppagnk rgkr
//
LOCUS       XP_047286761             325 aa            linear   PRI 05-AUG-2025
DEFINITION  nucleoporin p58/p45 isoform X2 [Homo sapiens].
ACCESSION   XP_047286761
VERSION     XP_047286761.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430805.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..325
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..325
                     /product="nucleoporin p58/p45 isoform X2"
                     /calculated_mol_wt=34324
     Region          <1..325
                     /region_name="Nucleoporin_FG2"
                     /note="Nucleoporin FG repeated region; pfam15967"
                     /db_xref="CDD:435043"
     CDS             1..325
                     /gene="NUP58"
                     /gene_synonym="NUP45; NUPL1; PRO2463"
                     /coded_by="XM_047430805.1:2191..3168"
                     /db_xref="GeneID:9818"
                     /db_xref="HGNC:HGNC:20261"
                     /db_xref="MIM:607615"
ORIGIN      
        1 msskamlkvq edikalkqll slaangiqrn tlnidklkie taqelknaei alrtqktppg
       61 lqheyaapad yfrilvqqfe vqlqqyrqqi eelenhlatq annshitpqd lsmamqkiyq
      121 tfvalaaqlq sihenvkvlk eqylgyrkmf lgdavdvfet rraeakkwqn tprvttgptp
      181 fstmpnaaav amaatltqqq qpatgpqpsl gvsfgtpfgs gigtglqssg lgssnlggfg
      241 tssgfgcstt gastfgfgtt nkpsgslsag fgssstsgfn fsnpgitasa gltfgvsnpa
      301 sagfgtggql lqlkkppagn krgkr
//
LOCUS       XP_047286762             325 aa            linear   PRI 05-AUG-2025
DEFINITION  nucleoporin p58/p45 isoform X2 [Homo sapiens].
ACCESSION   XP_047286762
VERSION     XP_047286762.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430806.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..325
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..325
                     /product="nucleoporin p58/p45 isoform X2"
                     /calculated_mol_wt=34324
     Region          <1..325
                     /region_name="Nucleoporin_FG2"
                     /note="Nucleoporin FG repeated region; pfam15967"
                     /db_xref="CDD:435043"
     CDS             1..325
                     /gene="NUP58"
                     /gene_synonym="NUP45; NUPL1; PRO2463"
                     /coded_by="XM_047430806.1:2154..3131"
                     /db_xref="GeneID:9818"
                     /db_xref="HGNC:HGNC:20261"
                     /db_xref="MIM:607615"
ORIGIN      
        1 msskamlkvq edikalkqll slaangiqrn tlnidklkie taqelknaei alrtqktppg
       61 lqheyaapad yfrilvqqfe vqlqqyrqqi eelenhlatq annshitpqd lsmamqkiyq
      121 tfvalaaqlq sihenvkvlk eqylgyrkmf lgdavdvfet rraeakkwqn tprvttgptp
      181 fstmpnaaav amaatltqqq qpatgpqpsl gvsfgtpfgs gigtglqssg lgssnlggfg
      241 tssgfgcstt gastfgfgtt nkpsgslsag fgssstsgfn fsnpgitasa gltfgvsnpa
      301 sagfgtggql lqlkkppagn krgkr
//
LOCUS       XP_047286763             325 aa            linear   PRI 05-AUG-2025
DEFINITION  nucleoporin p58/p45 isoform X2 [Homo sapiens].
ACCESSION   XP_047286763
VERSION     XP_047286763.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430807.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 21% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..325
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..325
                     /product="nucleoporin p58/p45 isoform X2"
                     /calculated_mol_wt=34324
     Region          <1..325
                     /region_name="Nucleoporin_FG2"
                     /note="Nucleoporin FG repeated region; pfam15967"
                     /db_xref="CDD:435043"
     CDS             1..325
                     /gene="NUP58"
                     /gene_synonym="NUP45; NUPL1; PRO2463"
                     /coded_by="XM_047430807.1:1063..2040"
                     /db_xref="GeneID:9818"
                     /db_xref="HGNC:HGNC:20261"
                     /db_xref="MIM:607615"
ORIGIN      
        1 msskamlkvq edikalkqll slaangiqrn tlnidklkie taqelknaei alrtqktppg
       61 lqheyaapad yfrilvqqfe vqlqqyrqqi eelenhlatq annshitpqd lsmamqkiyq
      121 tfvalaaqlq sihenvkvlk eqylgyrkmf lgdavdvfet rraeakkwqn tprvttgptp
      181 fstmpnaaav amaatltqqq qpatgpqpsl gvsfgtpfgs gigtglqssg lgssnlggfg
      241 tssgfgcstt gastfgfgtt nkpsgslsag fgssstsgfn fsnpgitasa gltfgvsnpa
      301 sagfgtggql lqlkkppagn krgkr
//
LOCUS       XP_011533631             325 aa            linear   PRI 05-AUG-2025
DEFINITION  nucleoporin p58/p45 isoform X2 [Homo sapiens].
ACCESSION   XP_011533631
VERSION     XP_011533631.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535329.4
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 21% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..325
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..325
                     /product="nucleoporin p58/p45 isoform X2"
                     /calculated_mol_wt=34324
     Region          <1..325
                     /region_name="Nucleoporin_FG2"
                     /note="Nucleoporin FG repeated region; pfam15967"
                     /db_xref="CDD:435043"
     CDS             1..325
                     /gene="NUP58"
                     /gene_synonym="NUP45; NUPL1; PRO2463"
                     /coded_by="XM_011535329.4:1026..2003"
                     /db_xref="GeneID:9818"
                     /db_xref="HGNC:HGNC:20261"
                     /db_xref="MIM:607615"
ORIGIN      
        1 msskamlkvq edikalkqll slaangiqrn tlnidklkie taqelknaei alrtqktppg
       61 lqheyaapad yfrilvqqfe vqlqqyrqqi eelenhlatq annshitpqd lsmamqkiyq
      121 tfvalaaqlq sihenvkvlk eqylgyrkmf lgdavdvfet rraeakkwqn tprvttgptp
      181 fstmpnaaav amaatltqqq qpatgpqpsl gvsfgtpfgs gigtglqssg lgssnlggfg
      241 tssgfgcstt gastfgfgtt nkpsgslsag fgssstsgfn fsnpgitasa gltfgvsnpa
      301 sagfgtggql lqlkkppagn krgkr
//
LOCUS       XP_005266660            1273 aa            linear   PRI 05-AUG-2025
DEFINITION  TBC1 domain family member 4 isoform X1 [Homo sapiens].
ACCESSION   XP_005266660
VERSION     XP_005266660.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005266603.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1273
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1273
                     /product="TBC1 domain family member 4 isoform X1"
                     /calculated_mol_wt=143726
     Region          31..190
                     /region_name="PTB"
                     /note="Phosphotyrosine-binding domain,
                     phosphotyrosine-interaction (PI) domain; smart00462"
                     /db_xref="CDD:214675"
     Site            order(126..131,144,171,175)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:269911"
     Region          193..437
                     /region_name="PTB_TBC1D1_like"
                     /note="TBC1 domain family member 1 and related proteins
                     Phosphotyrosine-binding (PTB) domain; cd01269"
                     /db_xref="CDD:269967"
     Site            order(205,396,419)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:269967"
     Site            order(385..390,403,430,434)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:269967"
     Region          776..839
                     /region_name="DUF3350"
                     /note="Domain of unknown function (DUF3350); pfam11830"
                     /db_xref="CDD:463365"
     Region          893..1107
                     /region_name="TBC"
                     /note="Domain in Tre-2, BUB2p, and Cdc16p. Probable
                     Rab-GAPs; smart00164"
                     /db_xref="CDD:214540"
     Region          1136..>1242
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     CDS             1..1273
                     /gene="TBC1D4"
                     /gene_synonym="AS160; NIDDM5"
                     /coded_by="XM_005266603.3:403..4224"
                     /db_xref="GeneID:9882"
                     /db_xref="HGNC:HGNC:19165"
                     /db_xref="MIM:612465"
ORIGIN      
        1 meppsciqde pfphplepep gvsaqpgpgk psdkrfrlwy vggscldhrt tlpmlpwlma
       61 eirrrsqkpe aggcgapaar evilvlsapf lrcvpapgag asggtspsat qpnpavfife
      121 hkaqhisrfi hnshdltyfa ylikaqpddp esqmachvfr atdpsqvpdv issirqlska
      181 amkedakpsk dnedafynsq kfevlycgkv tvthkkapss liddcmekfs lheqqrlkiq
      241 geqrgpdpge dladlevvvp gspgdclpee adgtdthlgl pagasqpalt ssrvcfperi
      301 ledsgfdeqq efrsrcssvt gvqrrvhegs qksqprrrha sapshvqpsd seknrtmlfq
      361 vgrfeinlis pdtksvvlek nfkdisscsq gikhvdhfgf icrespepgl sqyicyvfqc
      421 aseslvdevm ltlkqafsta aalqsaktqi klceacpmhs lhklcerieg lyppraklvi
      481 qrhlssltdn eqadifervq kmkpvsdqee nelvilhlrq lceakqkthv higegpstis
      541 nstipenats sgrfkldilk nkakrsltss lenifsrdys pgdsppgtpp asppssawqt
      601 fpeedsdspq frrrahtfsh ppsstkrkln lqdgraqgvr spllrqssse qcsnlssvrr
      661 mykesnssss lpslhtsfsa psftapsflk sfyqnsgrls pqyeneirqd tasessdgeg
      721 rkrtsstcsn eslsvggtsv tprriswrqr iflrvaspmn kspsamqqqd gldrnellpl
      781 splsptmeee plvvflsged dpekieerkk skelrslwrk aihqqilllr mekenqklea
      841 srdelqsrkv kldyeevgac qkevlitwdk kllncrakir cdmedihtll kegvpksrrg
      901 eiwqflalqy rlrhrlpnkq qppdisykel lkqltaqqha ilvdlgrtfp thpyfsvqlg
      961 pgqlslfnll kayslldkev gycqgisfva gvlllhmsee qafemlkflm ydlgfrkqyr
     1021 pdmmslqiqm yqlsrllhdy hrdlynhlee neispslyaa pwfltlfasq fslgfvarvf
     1081 diiflqgtev ifkvalslls sqetlimece sfeniveflk ntlpdmntse mekiitqvfe
     1141 mdiskqlhay eveyhvlqde lqessysced setleklera nsqlkrqnmd lleklqvaht
     1201 kiqalesnle nlltretkmk slirtleqek mayqktveql rkllpadalv ncdlllrdln
     1261 cnpnnkakig nkp
//
LOCUS       XP_047286764            1265 aa            linear   PRI 05-AUG-2025
DEFINITION  TBC1 domain family member 4 isoform X2 [Homo sapiens].
ACCESSION   XP_047286764
VERSION     XP_047286764.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430808.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1265
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1265
                     /product="TBC1 domain family member 4 isoform X2"
                     /calculated_mol_wt=142851
     Region          31..190
                     /region_name="PTB"
                     /note="Phosphotyrosine-binding domain,
                     phosphotyrosine-interaction (PI) domain; smart00462"
                     /db_xref="CDD:214675"
     Site            order(126..131,144,171,175)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:269911"
     Region          193..437
                     /region_name="PTB_TBC1D1_like"
                     /note="TBC1 domain family member 1 and related proteins
                     Phosphotyrosine-binding (PTB) domain; cd01269"
                     /db_xref="CDD:269967"
     Site            order(205,396,419)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:269967"
     Site            order(385..390,403,430,434)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:269967"
     Region          768..831
                     /region_name="DUF3350"
                     /note="Domain of unknown function (DUF3350); pfam11830"
                     /db_xref="CDD:463365"
     Region          885..1099
                     /region_name="TBC"
                     /note="Domain in Tre-2, BUB2p, and Cdc16p. Probable
                     Rab-GAPs; smart00164"
                     /db_xref="CDD:214540"
     Region          1128..>1234
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     CDS             1..1265
                     /gene="TBC1D4"
                     /gene_synonym="AS160; NIDDM5"
                     /coded_by="XM_047430808.1:403..4200"
                     /db_xref="GeneID:9882"
                     /db_xref="HGNC:HGNC:19165"
                     /db_xref="MIM:612465"
ORIGIN      
        1 meppsciqde pfphplepep gvsaqpgpgk psdkrfrlwy vggscldhrt tlpmlpwlma
       61 eirrrsqkpe aggcgapaar evilvlsapf lrcvpapgag asggtspsat qpnpavfife
      121 hkaqhisrfi hnshdltyfa ylikaqpddp esqmachvfr atdpsqvpdv issirqlska
      181 amkedakpsk dnedafynsq kfevlycgkv tvthkkapss liddcmekfs lheqqrlkiq
      241 geqrgpdpge dladlevvvp gspgdclpee adgtdthlgl pagasqpalt ssrvcfperi
      301 ledsgfdeqq efrsrcssvt gvqrrvhegs qksqprrrha sapshvqpsd seknrtmlfq
      361 vgrfeinlis pdtksvvlek nfkdisscsq gikhvdhfgf icrespepgl sqyicyvfqc
      421 aseslvdevm ltlkqafsta aalqsaktqi klceacpmhs lhklcerieg lyppraklvi
      481 qrhlssltdn eqadifervq kmkpvsdqee nelvilhlrq lceakqkthv higegpstis
      541 nstipenats sgrfkldilk nkakrsltss lenifsrdys pgdsppgtpp asppssawqt
      601 fpeedsdspq frrrahtfsh ppsstkrkln lqdgraqgvr spllrqssse qcsnlssvrr
      661 mykesnssss lpslhtsfsa psftapsflk sfyqnsgrls pqyeneisdg egrkrtsstc
      721 sneslsvggt svtprriswr qriflrvasp mnkspsamqq qdgldrnell plsplsptme
      781 eeplvvflsg eddpekieer kkskelrslw rkaihqqill lrmekenqkl easrdelqsr
      841 kvkldyeevg acqkevlitw dkkllncrak ircdmediht llkegvpksr rgeiwqflal
      901 qyrlrhrlpn kqqppdisyk ellkqltaqq hailvdlgrt fpthpyfsvq lgpgqlslfn
      961 llkayslldk evgycqgisf vagvlllhms eeqafemlkf lmydlgfrkq yrpdmmslqi
     1021 qmyqlsrllh dyhrdlynhl eeneispsly aapwfltlfa sqfslgfvar vfdiiflqgt
     1081 evifkvalsl lssqetlime cesfenivef lkntlpdmnt semekiitqv femdiskqlh
     1141 ayeveyhvlq delqessysc edsetlekle ransqlkrqn mdlleklqva htkiqalesn
     1201 lenlltretk mkslirtleq ekmayqktve qlrkllpada lvncdlllrd lncnpnnkak
     1261 ignkp
//
LOCUS       XP_011533633            1261 aa            linear   PRI 05-AUG-2025
DEFINITION  TBC1 domain family member 4 isoform X3 [Homo sapiens].
ACCESSION   XP_011533633
VERSION     XP_011533633.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535331.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1261
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1261
                     /product="TBC1 domain family member 4 isoform X3"
                     /calculated_mol_wt=142228
     Region          31..190
                     /region_name="PTB"
                     /note="Phosphotyrosine-binding domain,
                     phosphotyrosine-interaction (PI) domain; smart00462"
                     /db_xref="CDD:214675"
     Site            order(126..131,144,171,175)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:269911"
     Region          193..437
                     /region_name="PTB_TBC1D1_like"
                     /note="TBC1 domain family member 1 and related proteins
                     Phosphotyrosine-binding (PTB) domain; cd01269"
                     /db_xref="CDD:269967"
     Site            order(205,396,419)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:269967"
     Site            order(385..390,403,430,434)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:269967"
     Region          764..827
                     /region_name="DUF3350"
                     /note="Domain of unknown function (DUF3350); pfam11830"
                     /db_xref="CDD:463365"
     Region          881..1095
                     /region_name="TBC"
                     /note="Domain in Tre-2, BUB2p, and Cdc16p. Probable
                     Rab-GAPs; smart00164"
                     /db_xref="CDD:214540"
     Region          1124..>1230
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     CDS             1..1261
                     /gene="TBC1D4"
                     /gene_synonym="AS160; NIDDM5"
                     /coded_by="XM_011535331.3:403..4188"
                     /db_xref="GeneID:9882"
                     /db_xref="HGNC:HGNC:19165"
                     /db_xref="MIM:612465"
ORIGIN      
        1 meppsciqde pfphplepep gvsaqpgpgk psdkrfrlwy vggscldhrt tlpmlpwlma
       61 eirrrsqkpe aggcgapaar evilvlsapf lrcvpapgag asggtspsat qpnpavfife
      121 hkaqhisrfi hnshdltyfa ylikaqpddp esqmachvfr atdpsqvpdv issirqlska
      181 amkedakpsk dnedafynsq kfevlycgkv tvthkkapss liddcmekfs lheqqrlkiq
      241 geqrgpdpge dladlevvvp gspgdclpee adgtdthlgl pagasqpalt ssrvcfperi
      301 ledsgfdeqq efrsrcssvt gvqrrvhegs qksqprrrha sapshvqpsd seknrtmlfq
      361 vgrfeinlis pdtksvvlek nfkdisscsq gikhvdhfgf icrespepgl sqyicyvfqc
      421 aseslvdevm ltlkqafsta aalqsaktqi klceacpmhs lhklcerieg lyppraklvi
      481 qrhlssltdn eqadifervq tisnstipen atssgrfkld ilknkakrsl tsslenifsr
      541 ganrmrgrlg svdsfersns lasekdyspg dsppgtppas ppssawqtfp eedsdspqfr
      601 rrahtfshpp sstkrklnlq dgraqgvrsp llrqssseqc snlssvrrmy kesnsssslp
      661 slhtsfsaps ftapsflksf yqnsgrlspq yeneirqdta sessdgegrk rtsstcsnes
      721 lsvggtsvtp rriswrqrif lrvaspmnks psamqqqdgl drnellplsp lsptmeeepl
      781 vvflsgeddp ekieerkksk elrslwrkai hqqilllrme kenqkleasr delqsrkvkl
      841 dyeevgacqk evlitwdkkl lncrakircd medihtllke gvpksrrgei wqflalqyrl
      901 rhrlpnkqqp pdisykellk qltaqqhail vdlgrtfpth pyfsvqlgpg qlslfnllka
      961 yslldkevgy cqgisfvagv lllhmseeqa femlkflmyd lgfrkqyrpd mmslqiqmyq
     1021 lsrllhdyhr dlynhleene ispslyaapw fltlfasqfs lgfvarvfdi iflqgtevif
     1081 kvalsllssq etlimecesf eniveflknt lpdmntseme kiitqvfemd iskqlhayev
     1141 eyhvlqdelq essyscedse tleklerans qlkrqnmdll eklqvahtki qalesnlenl
     1201 ltretkmksl irtleqekma yqktveqlrk llpadalvnc dlllrdlncn pnnkakignk
     1261 p
//
LOCUS       XP_047286765            1210 aa            linear   PRI 05-AUG-2025
DEFINITION  TBC1 domain family member 4 isoform X4 [Homo sapiens].
ACCESSION   XP_047286765
VERSION     XP_047286765.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430809.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1210
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1210
                     /product="TBC1 domain family member 4 isoform X4"
                     /calculated_mol_wt=136718
     Region          31..190
                     /region_name="PTB"
                     /note="Phosphotyrosine-binding domain,
                     phosphotyrosine-interaction (PI) domain; smart00462"
                     /db_xref="CDD:214675"
     Site            order(126..131,144,171,175)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:269911"
     Region          193..437
                     /region_name="PTB_TBC1D1_like"
                     /note="TBC1 domain family member 1 and related proteins
                     Phosphotyrosine-binding (PTB) domain; cd01269"
                     /db_xref="CDD:269967"
     Site            order(205,396,419)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:269967"
     Site            order(385..390,403,430,434)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:269967"
     Region          713..776
                     /region_name="DUF3350"
                     /note="Domain of unknown function (DUF3350); pfam11830"
                     /db_xref="CDD:463365"
     Region          830..1044
                     /region_name="TBC"
                     /note="Domain in Tre-2, BUB2p, and Cdc16p. Probable
                     Rab-GAPs; smart00164"
                     /db_xref="CDD:214540"
     Region          1073..>1179
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     CDS             1..1210
                     /gene="TBC1D4"
                     /gene_synonym="AS160; NIDDM5"
                     /coded_by="XM_047430809.1:403..4035"
                     /db_xref="GeneID:9882"
                     /db_xref="HGNC:HGNC:19165"
                     /db_xref="MIM:612465"
ORIGIN      
        1 meppsciqde pfphplepep gvsaqpgpgk psdkrfrlwy vggscldhrt tlpmlpwlma
       61 eirrrsqkpe aggcgapaar evilvlsapf lrcvpapgag asggtspsat qpnpavfife
      121 hkaqhisrfi hnshdltyfa ylikaqpddp esqmachvfr atdpsqvpdv issirqlska
      181 amkedakpsk dnedafynsq kfevlycgkv tvthkkapss liddcmekfs lheqqrlkiq
      241 geqrgpdpge dladlevvvp gspgdclpee adgtdthlgl pagasqpalt ssrvcfperi
      301 ledsgfdeqq efrsrcssvt gvqrrvhegs qksqprrrha sapshvqpsd seknrtmlfq
      361 vgrfeinlis pdtksvvlek nfkdisscsq gikhvdhfgf icrespepgl sqyicyvfqc
      421 aseslvdevm ltlkqafsta aalqsaktqi klceacpmhs lhklcerieg lyppraklvi
      481 qrhlssltdn eqadifervq kmkpvsdqee nelvilhlrq lceakqkthv higegpstis
      541 nstipenats sgrfkldilk nkakrsltss lenifsrdys pgdsppgtpp asppssawqt
      601 fpeedsdspq frrrahtfsh ppsstkrkln lqdgraqgvr spllrqssse qcsdgegrkr
      661 tsstcsnesl svggtsvtpr riswrqrifl rvaspmnksp samqqqdgld rnellplspl
      721 sptmeeeplv vflsgeddpe kieerkkske lrslwrkaih qqilllrmek enqkleasrd
      781 elqsrkvkld yeevgacqke vlitwdkkll ncrakircdm edihtllkeg vpksrrgeiw
      841 qflalqyrlr hrlpnkqqpp disykellkq ltaqqhailv dlgrtfpthp yfsvqlgpgq
      901 lslfnllkay slldkevgyc qgisfvagvl llhmseeqaf emlkflmydl gfrkqyrpdm
      961 mslqiqmyql srllhdyhrd lynhleenei spslyaapwf ltlfasqfsl gfvarvfdii
     1021 flqgtevifk valsllssqe tlimecesfe niveflkntl pdmntsemek iitqvfemdi
     1081 skqlhayeve yhvlqdelqe ssyscedset lekleransq lkrqnmdlle klqvahtkiq
     1141 alesnlenll tretkmksli rtleqekmay qktveqlrkl lpadalvncd lllrdlncnp
     1201 nnkakignkp
//
LOCUS       XP_047286766            1198 aa            linear   PRI 05-AUG-2025
DEFINITION  TBC1 domain family member 4 isoform X5 [Homo sapiens].
ACCESSION   XP_047286766
VERSION     XP_047286766.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430810.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1198
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1198
                     /product="TBC1 domain family member 4 isoform X5"
                     /calculated_mol_wt=135221
     Region          31..190
                     /region_name="PTB"
                     /note="Phosphotyrosine-binding domain,
                     phosphotyrosine-interaction (PI) domain; smart00462"
                     /db_xref="CDD:214675"
     Site            order(126..131,144,171,175)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:269911"
     Region          193..437
                     /region_name="PTB_TBC1D1_like"
                     /note="TBC1 domain family member 1 and related proteins
                     Phosphotyrosine-binding (PTB) domain; cd01269"
                     /db_xref="CDD:269967"
     Site            order(205,396,419)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:269967"
     Site            order(385..390,403,430,434)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:269967"
     Region          701..764
                     /region_name="DUF3350"
                     /note="Domain of unknown function (DUF3350); pfam11830"
                     /db_xref="CDD:463365"
     Region          818..1032
                     /region_name="TBC"
                     /note="Domain in Tre-2, BUB2p, and Cdc16p. Probable
                     Rab-GAPs; smart00164"
                     /db_xref="CDD:214540"
     Region          1061..>1167
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     CDS             1..1198
                     /gene="TBC1D4"
                     /gene_synonym="AS160; NIDDM5"
                     /coded_by="XM_047430810.1:403..3999"
                     /db_xref="GeneID:9882"
                     /db_xref="HGNC:HGNC:19165"
                     /db_xref="MIM:612465"
ORIGIN      
        1 meppsciqde pfphplepep gvsaqpgpgk psdkrfrlwy vggscldhrt tlpmlpwlma
       61 eirrrsqkpe aggcgapaar evilvlsapf lrcvpapgag asggtspsat qpnpavfife
      121 hkaqhisrfi hnshdltyfa ylikaqpddp esqmachvfr atdpsqvpdv issirqlska
      181 amkedakpsk dnedafynsq kfevlycgkv tvthkkapss liddcmekfs lheqqrlkiq
      241 geqrgpdpge dladlevvvp gspgdclpee adgtdthlgl pagasqpalt ssrvcfperi
      301 ledsgfdeqq efrsrcssvt gvqrrvhegs qksqprrrha sapshvqpsd seknrtmlfq
      361 vgrfeinlis pdtksvvlek nfkdisscsq gikhvdhfgf icrespepgl sqyicyvfqc
      421 aseslvdevm ltlkqafsta aalqsaktqi klceacpmhs lhklcerieg lyppraklvi
      481 qrhlssltdn eqadifervq tisnstipen atssgrfkld ilknkakrsl tsslenifsr
      541 ganrmrgrlg svdsfersns lasekdyspg dsppgtppas ppssawqtfp eedsdspqfr
      601 rrahtfshpp sstkrklnlq dgraqgvrsp llrqssseqc sdgegrkrts stcsneslsv
      661 ggtsvtprri swrqriflrv aspmnkspsa mqqqdgldrn ellplsplsp tmeeeplvvf
      721 lsgeddpeki eerkkskelr slwrkaihqq illlrmeken qkleasrdel qsrkvkldye
      781 evgacqkevl itwdkkllnc rakircdmed ihtllkegvp ksrrgeiwqf lalqyrlrhr
      841 lpnkqqppdi sykellkqlt aqqhailvdl grtfpthpyf svqlgpgqls lfnllkaysl
      901 ldkevgycqg isfvagvlll hmseeqafem lkflmydlgf rkqyrpdmms lqiqmyqlsr
      961 llhdyhrdly nhleeneisp slyaapwflt lfasqfslgf varvfdiifl qgtevifkva
     1021 lsllssqetl imecesfeni veflkntlpd mntsemekii tqvfemdisk qlhayeveyh
     1081 vlqdelqess yscedsetle kleransqlk rqnmdllekl qvahtkiqal esnlenlltr
     1141 etkmkslirt leqekmayqk tveqlrkllp adalvncdll lrdlncnpnn kakignkp
//
LOCUS       XP_047286767            1173 aa            linear   PRI 05-AUG-2025
DEFINITION  TBC1 domain family member 4 isoform X6 [Homo sapiens].
ACCESSION   XP_047286767
VERSION     XP_047286767.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430811.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1173
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1173
                     /product="TBC1 domain family member 4 isoform X6"
                     /calculated_mol_wt=132514
     Region          31..190
                     /region_name="PTB"
                     /note="Phosphotyrosine-binding domain,
                     phosphotyrosine-interaction (PI) domain; smart00462"
                     /db_xref="CDD:214675"
     Site            order(126..131,144,171,175)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:269911"
     Region          193..437
                     /region_name="PTB_TBC1D1_like"
                     /note="TBC1 domain family member 1 and related proteins
                     Phosphotyrosine-binding (PTB) domain; cd01269"
                     /db_xref="CDD:269967"
     Site            order(205,396,419)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:269967"
     Site            order(385..390,403,430,434)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:269967"
     Region          676..739
                     /region_name="DUF3350"
                     /note="Domain of unknown function (DUF3350); pfam11830"
                     /db_xref="CDD:463365"
     Region          793..1007
                     /region_name="TBC"
                     /note="Domain in Tre-2, BUB2p, and Cdc16p. Probable
                     Rab-GAPs; smart00164"
                     /db_xref="CDD:214540"
     Region          1036..>1142
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     CDS             1..1173
                     /gene="TBC1D4"
                     /gene_synonym="AS160; NIDDM5"
                     /coded_by="XM_047430811.1:403..3924"
                     /db_xref="GeneID:9882"
                     /db_xref="HGNC:HGNC:19165"
                     /db_xref="MIM:612465"
ORIGIN      
        1 meppsciqde pfphplepep gvsaqpgpgk psdkrfrlwy vggscldhrt tlpmlpwlma
       61 eirrrsqkpe aggcgapaar evilvlsapf lrcvpapgag asggtspsat qpnpavfife
      121 hkaqhisrfi hnshdltyfa ylikaqpddp esqmachvfr atdpsqvpdv issirqlska
      181 amkedakpsk dnedafynsq kfevlycgkv tvthkkapss liddcmekfs lheqqrlkiq
      241 geqrgpdpge dladlevvvp gspgdclpee adgtdthlgl pagasqpalt ssrvcfperi
      301 ledsgfdeqq efrsrcssvt gvqrrvhegs qksqprrrha sapshvqpsd seknrtmlfq
      361 vgrfeinlis pdtksvvlek nfkdisscsq gikhvdhfgf icrespepgl sqyicyvfqc
      421 aseslvdevm ltlkqafsta aalqsaktqi klceacpmhs lhklcerieg lyppraklvi
      481 qrhlssltdn eqadifervq tisnstipen atssgrfkld ilknkakrsl tsslenifsr
      541 dyspgdsppg tppasppssa wqtfpeedsd spqfrrraht fshppsstkr klnlqdgraq
      601 gvrspllrqs sseqcsdgeg rkrtsstcsn eslsvggtsv tprriswrqr iflrvaspmn
      661 kspsamqqqd gldrnellpl splsptmeee plvvflsged dpekieerkk skelrslwrk
      721 aihqqilllr mekenqklea srdelqsrkv kldyeevgac qkevlitwdk kllncrakir
      781 cdmedihtll kegvpksrrg eiwqflalqy rlrhrlpnkq qppdisykel lkqltaqqha
      841 ilvdlgrtfp thpyfsvqlg pgqlslfnll kayslldkev gycqgisfva gvlllhmsee
      901 qafemlkflm ydlgfrkqyr pdmmslqiqm yqlsrllhdy hrdlynhlee neispslyaa
      961 pwfltlfasq fslgfvarvf diiflqgtev ifkvalslls sqetlimece sfeniveflk
     1021 ntlpdmntse mekiitqvfe mdiskqlhay eveyhvlqde lqessysced setleklera
     1081 nsqlkrqnmd lleklqvaht kiqalesnle nlltretkmk slirtleqek mayqktveql
     1141 rkllpadalv ncdlllrdln cnpnnkakig nkp
//
LOCUS       XP_006719966            1140 aa            linear   PRI 05-AUG-2025
DEFINITION  TBC1 domain family member 4 isoform X7 [Homo sapiens].
ACCESSION   XP_006719966
VERSION     XP_006719966.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006719903.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1140
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..1140
                     /product="TBC1 domain family member 4 isoform X7"
                     /calculated_mol_wt=129277
     Region          35..279
                     /region_name="PTB_TBC1D1_like"
                     /note="TBC1 domain family member 1 and related proteins
                     Phosphotyrosine-binding (PTB) domain; cd01269"
                     /db_xref="CDD:269967"
     Site            order(47,238,261)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:269967"
     Site            order(227..232,245,272,276)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:269967"
     Region          643..706
                     /region_name="DUF3350"
                     /note="Domain of unknown function (DUF3350); pfam11830"
                     /db_xref="CDD:463365"
     Region          760..974
                     /region_name="TBC"
                     /note="Domain in Tre-2, BUB2p, and Cdc16p. Probable
                     Rab-GAPs; smart00164"
                     /db_xref="CDD:214540"
     CDS             1..1140
                     /gene="TBC1D4"
                     /gene_synonym="AS160; NIDDM5"
                     /coded_by="XM_006719903.4:7718..11140"
                     /db_xref="GeneID:9882"
                     /db_xref="HGNC:HGNC:19165"
                     /db_xref="MIM:612465"
ORIGIN      
        1 medvqtpcvp dvissirqls kaamkedakp skdnedafyn sqkfevlycg kvtvthkkap
       61 ssliddcmek fslheqqrlk iqgeqrgpdp gedladlevv vpgspgdclp eeadgtdthl
      121 glpagasqpa ltssrvcfpe riledsgfde qqefrsrcss vtgvqrrvhe gsqksqprrr
      181 hasapshvqp sdseknrtml fqvgrfeinl ispdtksvvl eknfkdissc sqgikhvdhf
      241 gficrespep glsqyicyvf qcaseslvde vmltlkqafs taaalqsakt qiklceacpm
      301 hslhklceri eglypprakl viqrhlsslt dneqadifer vqkmkpvsdq eenelvilhl
      361 rqlceakqkt hvhigegpst isnstipena tssgrfkldi lknkakrslt sslenifsrg
      421 anrmrgrlgs vdsfersnsl asekdyspgd sppgtppasp pssawqtfpe edsdspqfrr
      481 rahtfshpps stkrklnlqd graqgvrspl lrqssseqcs nlssvrrmyk esnsssslps
      541 lhtsfsapsf tapsflksfy qnsgrlspqy eneirqdtas essdgegrkr tsstcsnesl
      601 svggtsvtpr riswrqrifl rvaspmnksp samqqqdgld rnellplspl sptmeeeplv
      661 vflsgeddpe kieerkkske lrslwrkaih qqilllrmek enqkleasrd elqsrkvkld
      721 yeevgacqke vlitwdkkll ncrakircdm edihtllkeg vpksrrgeiw qflalqyrlr
      781 hrlpnkqqpp disykellkq ltaqqhailv dlgrtfpthp yfsvqlgpgq lslfnllkay
      841 slldkevgyc qgisfvagvl llhmseeqaf emlkflmydl gfrkqyrpdm mslqiqmyql
      901 srllhdyhrd lynhleenei spslyaapwf ltlfasqfsl gfvarvfdii flqgtevifk
      961 valsllssqe tlimecesfe niveflkntl pdmntsemek iitqvfemdi skqlhayeve
     1021 yhvlqdelqe ssyscedset lekleransq lkrqnmdlle klqvahtkiq alesnlenll
     1081 tretkmksli rtleqekmay qktveqlrkl lpadalvncd lllrdlncnp nnkakignkp
//
LOCUS       XP_047286768             515 aa            linear   PRI 05-AUG-2025
DEFINITION  TBC1 domain family member 4 isoform X8 [Homo sapiens].
ACCESSION   XP_047286768
VERSION     XP_047286768.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430812.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..515
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..515
                     /product="TBC1 domain family member 4 isoform X8"
                     /calculated_mol_wt=59965
     Region          18..81
                     /region_name="DUF3350"
                     /note="Domain of unknown function (DUF3350); pfam11830"
                     /db_xref="CDD:463365"
     Region          135..349
                     /region_name="TBC"
                     /note="Domain in Tre-2, BUB2p, and Cdc16p. Probable
                     Rab-GAPs; smart00164"
                     /db_xref="CDD:214540"
     CDS             1..515
                     /gene="TBC1D4"
                     /gene_synonym="AS160; NIDDM5"
                     /coded_by="XM_047430812.1:480..2027"
                     /db_xref="GeneID:9882"
                     /db_xref="HGNC:HGNC:19165"
                     /db_xref="MIM:612465"
ORIGIN      
        1 mnkspsamqq qdgldrnell plsplsptme eeplvvflsg eddpekieer kkskelrslw
       61 rkaihqqill lrmekenqkl easrdelqsr kvkldyeevg acqkevlitw dkkllncrak
      121 ircdmediht llkegvpksr rgeiwqflal qyrlrhrlpn kqqppdisyk ellkqltaqq
      181 hailvdlgrt fpthpyfsvq lgpgqlslfn llkayslldk evgycqgisf vagvlllhms
      241 eeqafemlkf lmydlgfrkq yrpdmmslqi qmyqlsrllh dyhrdlynhl eeneispsly
      301 aapwfltlfa sqfslgfvar vfdiiflqgt evifkvalsl lssqetlime cesfenivef
      361 lkntlpdmnt semekiitqv femdiskqlh ayeveyhvlq delqessysc edsetlekle
      421 ransqlkrqn mdlleklqva htkiqalesn lenlltretk mkslirtleq ekmayqktve
      481 qlrkllpada lvncdlllrd lncnpnnkak ignkp
//
LOCUS       XP_047286769             116 aa            linear   PRI 05-AUG-2025
DEFINITION  nitric oxide synthase-like [Homo sapiens].
ACCESSION   XP_047286769
VERSION     XP_047286769.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430813.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..116
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..116
                     /product="nitric oxide synthase-like"
                     /calculated_mol_wt=11684
     CDS             1..116
                     /gene="LOC124903130"
                     /coded_by="XM_047430813.1:556..906"
                     /db_xref="GeneID:124903130"
ORIGIN      
        1 mtstpsacdl tlpdvtstps acdltlpdvt stpsacdltl pdvtstpsac dltlpdvtst
       61 psacdltlpd vtstpsacdl tlpdvtstps acdltlpdmt stpsacdlta rrdlhp
//
LOCUS       XP_011533636             226 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein LOC101927375 isoform X1 [Homo sapiens].
ACCESSION   XP_011533636
VERSION     XP_011533636.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535334.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..226
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..226
                     /product="uncharacterized protein LOC101927375 isoform X1"
                     /calculated_mol_wt=24724
     CDS             1..226
                     /gene="LOC101927375"
                     /coded_by="XM_011535334.3:313..993"
                     /db_xref="GeneID:101927375"
ORIGIN      
        1 mkktsgfrrg kgglpwgsvs spgkvgagag sesadhassq prrhdpdkgf drlrraagrh
       61 rtetmrrils lpksgvddrd eknrlsneqs sgdswlsidd elfdsgtktt fenvpqkyds
      121 hltgaddgqr gkitikeqed slqqyhhlkp kvemkecvsn qavgmkdvqa ctsafsaldf
      181 nsltfsnelh ersenlkvgd lcpfvsppmt ntvlgstdlg kmnlid
//
LOCUS       XP_011533637             226 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein LOC101927375 isoform X1 [Homo sapiens].
ACCESSION   XP_011533637
VERSION     XP_011533637.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535335.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..226
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..226
                     /product="uncharacterized protein LOC101927375 isoform X1"
                     /calculated_mol_wt=24724
     CDS             1..226
                     /gene="LOC101927375"
                     /coded_by="XM_011535335.3:313..993"
                     /db_xref="GeneID:101927375"
ORIGIN      
        1 mkktsgfrrg kgglpwgsvs spgkvgagag sesadhassq prrhdpdkgf drlrraagrh
       61 rtetmrrils lpksgvddrd eknrlsneqs sgdswlsidd elfdsgtktt fenvpqkyds
      121 hltgaddgqr gkitikeqed slqqyhhlkp kvemkecvsn qavgmkdvqa ctsafsaldf
      181 nsltfsnelh ersenlkvgd lcpfvsppmt ntvlgstdlg kmnlid
//
LOCUS       XP_047286773             144 aa            linear   PRI 05-AUG-2025
DEFINITION  ankyrin repeat domain-containing protein 26-like isoform X2 [Homo
            sapiens].
ACCESSION   XP_047286773
VERSION     XP_047286773.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430817.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..144
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..144
                     /product="ankyrin repeat domain-containing protein 26-like
                     isoform X2"
                     /calculated_mol_wt=15646
     CDS             1..144
                     /gene="LOC101927375"
                     /coded_by="XM_047430817.1:313..747"
                     /db_xref="GeneID:101927375"
ORIGIN      
        1 mkktsgfrrg kgglpwgsvs spgkvgagag sesadhassq prrhdpdkgf drlrraagrh
       61 rtetmrrils lpksgvddrd eknrlsneqs sgdswlsidd elfdsgtktt fenvpqkyds
      121 hltgaddgqr gkitikeqeg phsq
//
LOCUS       XP_011533638             144 aa            linear   PRI 05-AUG-2025
DEFINITION  ankyrin repeat domain-containing protein 26-like isoform X2 [Homo
            sapiens].
ACCESSION   XP_011533638
VERSION     XP_011533638.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011535336.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..144
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..144
                     /product="ankyrin repeat domain-containing protein 26-like
                     isoform X2"
                     /calculated_mol_wt=15646
     CDS             1..144
                     /gene="LOC101927375"
                     /coded_by="XM_011535336.3:313..747"
                     /db_xref="GeneID:101927375"
ORIGIN      
        1 mkktsgfrrg kgglpwgsvs spgkvgagag sesadhassq prrhdpdkgf drlrraagrh
       61 rtetmrrils lpksgvddrd eknrlsneqs sgdswlsidd elfdsgtktt fenvpqkyds
      121 hltgaddgqr gkitikeqeg phsq
//
LOCUS       XP_047286775             265 aa            linear   PRI 05-AUG-2025
DEFINITION  translation initiation factor IF-2-like [Homo sapiens].
ACCESSION   XP_047286775
VERSION     XP_047286775.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430819.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..265
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..265
                     /product="translation initiation factor IF-2-like"
                     /calculated_mol_wt=27864
     CDS             1..265
                     /gene="LOC124903151"
                     /coded_by="XM_047430819.1:12..809"
                     /db_xref="GeneID:124903151"
ORIGIN      
        1 mlrgsqapgp raaplyarap prppahrrra hprspagsag nnylragtas alalgagaga
       61 prargaregr gsgqgaagva rgrrrkapvs pssrepcrtf rgrsgsfslp aarplraale
      121 rlrrgekapt nfprlgggil pgpsgarrwg stcshfsptr rpkeapaghc wsqlgtgrnp
      181 rgtarwdsrg gtspcaerds plgrwepfnt ngagdalihm hpnttptpqa lsspvtditf
      241 yghifislsy nygqgndelc gdfkt
//
LOCUS       XP_047286777             132 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein LOC124903162 [Homo sapiens].
ACCESSION   XP_047286777
VERSION     XP_047286777.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430821.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..132
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..132
                     /product="uncharacterized protein LOC124903162"
                     /calculated_mol_wt=14971
     CDS             1..132
                     /gene="LOC124903162"
                     /coded_by="XM_047430821.1:64..462"
                     /db_xref="GeneID:124903162"
ORIGIN      
        1 mhhndrlqtg aswydfcrek maippnvwpp pakaktfvgf flyclnkeef vhslsgsgfh
       61 pmamwelqdl isgltcasil phsiwlklll hfllgcdhsg sptvhqsqhl kgekiffclv
      121 ffkilmmdsh qg
//
LOCUS       XP_047286778             108 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein LOC124903164 [Homo sapiens].
ACCESSION   XP_047286778
VERSION     XP_047286778.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430822.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..108
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..108
                     /product="uncharacterized protein LOC124903164"
                     /calculated_mol_wt=11685
     Region          <34..>75
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..108
                     /gene="LOC124903164"
                     /coded_by="XM_047430822.1:1336..1662"
                     /db_xref="GeneID:124903164"
ORIGIN      
        1 mksheqfrgs scehhgrplp crrsrdplql ghyisdtgis pmpegtaqdt sfslicstps
       61 ytivydanny dgaiahsvth qlppsrgtql shtrhaklct aitgplnt
//
LOCUS       XP_047286780             207 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein LOC124903173 [Homo sapiens].
ACCESSION   XP_047286780
VERSION     XP_047286780.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430824.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..207
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..207
                     /product="uncharacterized protein LOC124903173"
                     /calculated_mol_wt=22341
     CDS             1..207
                     /gene="LOC124903173"
                     /coded_by="XM_047430824.1:100..723"
                     /db_xref="GeneID:124903173"
ORIGIN      
        1 malqlrwfkh rrpfflllia qlcvhwpphl ppdqrgfclp qhcqpgvfld sspgppsapl
       61 ppsaltsrpp slllgnlawv glpsqpsrlf flslaaclah hcgqvslsen tisshhgpvy
      121 kavshlpits dqirtlrlwi eadatvpgkp hcppipalas vpvrsctmll sailpspalp
      181 acwscialhl tdsystalas pkhtwps
//
LOCUS       XP_047286784             122 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein LOC124903185 [Homo sapiens].
ACCESSION   XP_047286784
VERSION     XP_047286784.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430828.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..122
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..122
                     /product="uncharacterized protein LOC124903185"
                     /calculated_mol_wt=13669
     Region          <72..96
                     /region_name="CE4_SF"
                     /note="Catalytic NodB homology domain of the carbohydrate
                     esterase 4 superfamily; cl15692"
                     /db_xref="CDD:472828"
     CDS             1..122
                     /gene="LOC124903185"
                     /coded_by="XM_047430828.1:558..926"
                     /db_xref="GeneID:124903185"
ORIGIN      
        1 merekskpwr skqlrfdknn ksgsfssfsk pfcqnklvll grrnclrpya picsslqkcl
       61 glfhtepvgg ggdhcrwtgq iarapilerv lshtqkegml hrgqeesrqt glaglprsvc
      121 lf
//
LOCUS       XP_047286789             187 aa            linear   PRI 05-AUG-2025
DEFINITION  heparan sulfate glucosamine 3-O-sulfotransferase 4-like [Homo
            sapiens].
ACCESSION   XP_047286789
VERSION     XP_047286789.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430833.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..187
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..187
                     /product="heparan sulfate glucosamine 3-O-sulfotransferase
                     4-like"
                     /calculated_mol_wt=18737
     CDS             1..187
                     /gene="LOC124903206"
                     /coded_by="XM_047430833.1:225..788"
                     /db_xref="GeneID:124903206"
ORIGIN      
        1 merererete eagaggrrrg wvqgamvevt gwlarlrspr hcqragphgp aepsplspar
       61 gmprlrcplt apgappllll lllffsssss sflsfsfffs sasrscsala lpesgawaas
      121 ggalppphpp pralsaaaaa aaaaaaagpp agaaagapta daasrgapgr iawagppesh
      181 shlqsag
//
LOCUS       XP_047286791             196 aa            linear   PRI 05-AUG-2025
DEFINITION  WAS/WASL-interacting protein family member 1-like [Homo sapiens].
ACCESSION   XP_047286791
VERSION     XP_047286791.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430835.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..196
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..196
                     /product="WAS/WASL-interacting protein family member
                     1-like"
                     /calculated_mol_wt=21082
     CDS             1..196
                     /gene="LOC124903211"
                     /coded_by="XM_047430835.1:10..600"
                     /db_xref="GeneID:124903211"
ORIGIN      
        1 mggepgralg argphfgrgr plprsgwarp ipvprfpsps pgrisvppqp rnagrfqgpr
       61 prvrehrapd rerrapfrgg qrgaegapvs hplagalrgv lcaihlsacr eveiafgrgv
      121 lsphrcrstp flprkrpltt plqepplpst gasfppprqe rpfsphrsal ptpgapcaqq
      181 tgrwagvhyl carcgr
//
LOCUS       XP_047286794             492 aa            linear   PRI 05-AUG-2025
DEFINITION  MAGE-like protein 2 [Homo sapiens].
ACCESSION   XP_047286794
VERSION     XP_047286794.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430838.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..492
                     /product="MAGE-like protein 2"
                     /calculated_mol_wt=51225
     Region          <23..391
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..492
                     /gene="LOC124903217"
                     /coded_by="XM_047430838.1:74..1552"
                     /db_xref="GeneID:124903217"
ORIGIN      
        1 mfcffstmit hlhfhvstls twspsprsss tvhskgsils hgdppgstrp drssqvrsat
       61 qvlpgllsat evlpgplsas evlpgpflat evlpgllsas evlpdlflat evlpgllsat
      121 evlpgllsat evlpdplshr gpprsalshr gppgstvrhr gppgsalvhr gppgsalvhr
      181 gppgsalchr gpprsalshr gppgsalshr gppgsalchr gpprsaqpqr ssqvrsqpqr
      241 ssrvhcqaqr ssrvcsrpqr sswvcslpqr ssrvcslpqr ssrvhcqaqr ssrvcscpqr
      301 sswvcsrpqm ssqvcsatev lpgplsatev llgplsatev lpgllsatev lpdplshrgp
      361 pgsalghrgp pgsvlshrgp pgsalshrgp pgstvrhrgp pgsalvhrgp pgsvlghrcl
      421 prsaqpqrss rvcsrpqmss qvcsaaevls gplsatkvll glllatevfp afpssarssr
      481 ffpelpssss gt
//
LOCUS       XP_047286795             323 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein LOC124903219 [Homo sapiens].
ACCESSION   XP_047286795
VERSION     XP_047286795.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430839.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..323
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..323
                     /product="uncharacterized protein LOC124903219"
                     /calculated_mol_wt=33040
     CDS             1..323
                     /gene="LOC124903219"
                     /coded_by="XM_047430839.1:1470..2441"
                     /db_xref="GeneID:124903219"
ORIGIN      
        1 mssgvsqgis hmssgvsqvs ltcpqvflrc lsrvlrcfsg vshvssgvsh lssgvsqvsl
       61 tcpqvslrvs ltcpqvsltc pqvsltcpqv flrclsrvlr clsrvlrcfs gvshvssgvs
      121 hvssgvshvs sgvshvssgv shvssgvsqa sltclqaslt cpqasltcpq asltcpqasl
      181 tcpqvshass gvsrvlrcls rvlrclsrvl rclshvlrcl srvlrcfsgv shvssgvshv
      241 ssgvshvssg vshvssgvsh assgvshmss gvshvssgvs qvsltcpqvs ltcpqvslrc
      301 pqvslmdpqa ssgvpgpves sly
//
LOCUS       XP_047286797             369 aa            linear   PRI 05-AUG-2025
DEFINITION  translation initiation factor IF-2-like isoform X1 [Homo sapiens].
ACCESSION   XP_047286797
VERSION     XP_047286797.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430841.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..369
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..369
                     /product="translation initiation factor IF-2-like isoform
                     X1"
                     /calculated_mol_wt=40115
     Region          <24..317
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..369
                     /gene="LOC105377805"
                     /coded_by="XM_047430841.1:1506..2615"
                     /db_xref="GeneID:105377805"
ORIGIN      
        1 meparpernr llshgagaag kkpppqprsr qnpketassa teparpernr llshgasaag
       61 kkpppqprsr qnpketassa teparpernr llshgagrtr kkppprprsr qnpketassa
      121 tepaepernr llshgasaag kkpppqprsr qnpketassa tepaepernr llghgagrtr
      181 kkppprprsr qnpketassa tepaepernr llghgagttg kkpppqprsw hnwkatlrae
      241 kqwvckewen tqkaghakrp pvsvngscpp rcpdapgsla tprerperat staftsggsv
      301 ppdtphrslg qrrnlvpahr rclhkepslq rdcgkqasgp wdqhqecqtw fseaaaflpr
      361 lplgatqgs
//
LOCUS       XP_047286798             369 aa            linear   PRI 05-AUG-2025
DEFINITION  translation initiation factor IF-2-like isoform X1 [Homo sapiens].
ACCESSION   XP_047286798
VERSION     XP_047286798.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430842.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..369
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..369
                     /product="translation initiation factor IF-2-like isoform
                     X1"
                     /calculated_mol_wt=40115
     Region          <24..317
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..369
                     /gene="LOC105377805"
                     /coded_by="XM_047430842.1:1506..2615"
                     /db_xref="GeneID:105377805"
ORIGIN      
        1 meparpernr llshgagaag kkpppqprsr qnpketassa teparpernr llshgasaag
       61 kkpppqprsr qnpketassa teparpernr llshgagrtr kkppprprsr qnpketassa
      121 tepaepernr llshgasaag kkpppqprsr qnpketassa tepaepernr llghgagrtr
      181 kkppprprsr qnpketassa tepaepernr llghgagttg kkpppqprsw hnwkatlrae
      241 kqwvckewen tqkaghakrp pvsvngscpp rcpdapgsla tprerperat staftsggsv
      301 ppdtphrslg qrrnlvpahr rclhkepslq rdcgkqasgp wdqhqecqtw fseaaaflpr
      361 lplgatqgs
//
LOCUS       XP_047286799             330 aa            linear   PRI 05-AUG-2025
DEFINITION  basic salivary proline-rich protein 3-like isoform X2 [Homo
            sapiens].
ACCESSION   XP_047286799
VERSION     XP_047286799.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430843.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..330
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..330
                     /product="basic salivary proline-rich protein 3-like
                     isoform X2"
                     /calculated_mol_wt=36473
     Region          20..>293
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     CDS             1..330
                     /gene="LOC105377805"
                     /coded_by="XM_047430843.1:1315..2307"
                     /db_xref="GeneID:105377805"
ORIGIN      
        1 meparpernr llshgagrtr kkpppqprsr qnqketassa tepaepernr llshgagaag
       61 kkpppqpwsr rgrketassa meparpernr llshgagrtq kkpppqprsr rgrketassa
      121 teparpernr llshgagrtr kkppprprsq rgrketassa tepaepernr llghgagrtr
      181 kkpppqprsr qnpketassa teparpernr llshgagrtr kkppprprsr qnpketassa
      241 tepaepernr llghgagrtr kkppprprsr qnrketassa tepaqrernr llshgagttg
      301 kqlselksng faksgkthrr rvmqnvlpcl
//
LOCUS       XP_035717004             409 aa            linear   PRI 05-AUG-2025
DEFINITION  protein SPT2 homolog [Homo sapiens].
ACCESSION   XP_035717004
VERSION     XP_035717004.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_035861111.2
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 32% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..409
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..409
                     /product="protein SPT2 homolog"
                     /calculated_mol_wt=43143
     CDS             1..409
                     /gene="LOC112268119"
                     /coded_by="XM_035861111.2:1..1230"
                     /db_xref="GeneID:112268119"
ORIGIN      
        1 mqngssvllg infpssalkm mvpvraevdl sgprgwgrpa ggglraggph lqlrgqeafs
       61 srlwtkggdk dgkaappggr rqertrlagr adgsaelrks gareqpnsgs gaerepgrkq
      121 rsprprgsrv iylhgwraaa tfppasraht qlavflgreh pretgpscps lplsltaaep
      181 rgptwksrgw qeaeglqkra gtsgdphsrr vrggssggal waragagdrt qrsgspfgrr
      241 gthrllpsaa rpssfssplp srpgelradr prthrgrsws agkgvggcpa vragpgpppg
      301 aafaapplap splapplpas hsklsgegrq tekygrkllv flgdpeeprk mthfacwgfs
      361 gftvrvyapv flpplkeavd gkeglkdpen scdstlqpgi hcaamkqqa
//
LOCUS       XP_047286802             256 aa            linear   PRI 05-AUG-2025
DEFINITION  NADH-ubiquinone oxidoreductase chain 5-like, partial [Homo
            sapiens].
ACCESSION   XP_047286802
VERSION     XP_047286802.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430846.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 14% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: incomplete on the amino end.
FEATURES             Location/Qualifiers
     source          1..256
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         <1..256
                     /product="NADH-ubiquinone oxidoreductase chain 5-like"
     CDS             1..256
                     /gene="LOC124903229"
                     /coded_by="XM_047430846.1:<1..771"
                     /db_xref="GeneID:124903229"
ORIGIN      
        1 yiythiyvym ciyihiytyi cvythiyiyv yicthicvyi cthicvyict hicvyicihi
       61 cvymytymcv yvyiyvciyv yiymciyvyi yvyicihicv ymytyicvhi yvyicvhiyv
      121 yicvyicvhi yvyicihiyv yicihiyicv yvytyicvyv ytyicvyvyt yicvyvytyi
      181 cvyvytyicv yvytyirici hicihiyvyi ciyvyiytyi yiyllikiye lftpyvnfip
      241 lftnqlyeeq dslqpa
//
LOCUS       XP_016876375             411 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein LOC107983958 [Homo sapiens].
ACCESSION   XP_016876375
VERSION     XP_016876375.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020886.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 8% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..411
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..411
                     /product="uncharacterized protein LOC107983958"
                     /calculated_mol_wt=44260
     CDS             1..411
                     /gene="LOC107983958"
                     /coded_by="XM_017020886.1:1..1236"
                     /db_xref="GeneID:107983958"
ORIGIN      
        1 mslflpaeaa sppqchlccp qppaqlsqvc pdpiralhcc fslppflsvc kdrrplqlsp
       61 vrnfskrsqg hqstgsgskc tvilksspqg pdpsallssn pvhgvrirvr cypqtllqsl
      121 swlksgglcy tkkslclccf gnalvhpsla slrassapss lqtppislqs pssrikkkkq
      181 kqktneeatg tsrfgarepi agaaqahlgk elsdssctqk vetaceprip gstrletlqa
      241 amavrscras sqptrssswl tkipfqpfwn cragqnfrnn tcnafilhpi espaqpgprg
      301 aassqhsqvp keqllpesci drslrssffl spachlscds cvgghvidat plpalslakt
      361 lfnalelsgw rhqlhdnqgp giqdpsvccn qrklnpphis dmhnshsahg h
//
LOCUS       XP_011535834             342 aa            linear   PRI 05-AUG-2025
DEFINITION  WAS/WASL-interacting protein family member 2-like [Homo sapiens].
ACCESSION   XP_011535834
VERSION     XP_011535834.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537532.4
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 8% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..342
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..342
                     /product="WAS/WASL-interacting protein family member
                     2-like"
                     /calculated_mol_wt=35903
     Region          <76..304
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..342
                     /gene="F10-AS2"
                     /coded_by="XM_011537532.4:1..1029"
                     /db_xref="GeneID:102724474"
                     /db_xref="HGNC:HGNC:58130"
ORIGIN      
        1 meslrpgstv ressvvaefa fqallnslli icfslsccrp hsplavlvfl lelgpvsllt
       61 lsrvaeprgl sflglplsis tattssqggh prpsaptpgv rpasgcefps pwtqlcllgs
      121 aqsvsldpql parppskacr npaetggwgl sssggaghga rgscpcsvls gwttqarrrs
      181 lpphlavlas shagaaeapv wdrpplppvl laasapartr tgphwpllrp aqpetgiqvq
      241 glplgpwgpr gclgnaaqqq asseaeafsp grageepdsq lhgeglragr pgmpsrppwe
      301 tgpssdrfwe vehlstlifp dfatsvyerf cpahdffgef ly
//
LOCUS       XP_047286803             119 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein LOC124903233 [Homo sapiens].
ACCESSION   XP_047286803
VERSION     XP_047286803.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430847.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..119
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..119
                     /product="uncharacterized protein LOC124903233"
                     /calculated_mol_wt=14102
     CDS             1..119
                     /gene="LOC124903233"
                     /coded_by="XM_047430847.1:152..511"
                     /db_xref="GeneID:124903233"
ORIGIN      
        1 mretfwlvfr legvtlynft vnnrlswgrk hmhkswckey fkhissisfi qdrarptlfl
       61 llcllnvktm rmntfmmlhf hllnsathet cnqllqakan pclqagvire rsfgfhiri
//
LOCUS       XP_047286804             119 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein LOC124903233 [Homo sapiens].
ACCESSION   XP_047286804
VERSION     XP_047286804.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430848.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..119
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..119
                     /product="uncharacterized protein LOC124903233"
                     /calculated_mol_wt=14102
     CDS             1..119
                     /gene="LOC124903233"
                     /coded_by="XM_047430848.1:142..501"
                     /db_xref="GeneID:124903233"
ORIGIN      
        1 mretfwlvfr legvtlynft vnnrlswgrk hmhkswckey fkhissisfi qdrarptlfl
       61 llcllnvktm rmntfmmlhf hllnsathet cnqllqakan pclqagvire rsfgfhiri
//
LOCUS       XP_047286811             174 aa            linear   PRI 05-AUG-2025
DEFINITION  formin-like protein 5 [Homo sapiens].
ACCESSION   XP_047286811
VERSION     XP_047286811.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430855.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..174
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..174
                     /product="formin-like protein 5"
                     /calculated_mol_wt=18652
     CDS             1..174
                     /gene="LOC124900338"
                     /coded_by="XM_047430855.1:63..587"
                     /db_xref="GeneID:124900338"
ORIGIN      
        1 mitrtlapir vkarsrgpwq pslhppphrg thschlhrgq lsptqlwppp ppassgsshp
       61 pawvragrps pppsalllav fttfppgqwr tpgdepegag rggvhaspaf flqrtlymvv
      121 rgrakvapap rllqrrrrlq llrcppppsa aattalgsrr rclraepaaa aapn
//
LOCUS       XP_047286814             230 aa            linear   PRI 05-AUG-2025
DEFINITION  translation initiation factor IF-2-like [Homo sapiens].
ACCESSION   XP_047286814
VERSION     XP_047286814.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430858.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..230
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     Protein         1..230
                     /product="translation initiation factor IF-2-like"
                     /calculated_mol_wt=24181
     CDS             1..230
                     /gene="LOC124903248"
                     /coded_by="XM_047430858.1:337..1029"
                     /db_xref="GeneID:124903248"
ORIGIN      
        1 mkfhrepiph qrnknwwhrd aredfkssgd trsfwgcarg spgcirgapf clrakkppts
       61 ssrvllpvgs vparsrnvrg galrstrasl gdvrgwvapp iparsppqap papssspslr
      121 pcalcsalrp vpvsvpalcp apcprsrsls rprleaspkv spgcatnlpr vpdpgpgpgp
      181 gpgpgpgpgp arppppfarf llrasatass cvlrflehse gwetgrvgkp
//
LOCUS       XP_005267304             500 aa            linear   PRI 05-AUG-2025
DEFINITION  poly [ADP-ribose] polymerase 2 isoform X1 [Homo sapiens].
ACCESSION   XP_005267304
VERSION     XP_005267304.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267247.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..500
                     /product="poly [ADP-ribose] polymerase 2 isoform X1"
                     /calculated_mol_wt=57107
     Region          32..489
                     /region_name="PLN03124"
                     /note="poly [ADP-ribose] polymerase; Provisional"
                     /db_xref="CDD:215591"
     CDS             1..500
                     /gene="PARP2"
                     /gene_synonym="ADPRT2; ADPRTL2; ADPRTL3; ARTD2; pADPRT-2;
                     PARP-2"
                     /coded_by="XM_005267247.4:8..1510"
                     /db_xref="GeneID:10038"
                     /db_xref="HGNC:HGNC:272"
                     /db_xref="MIM:607725"
ORIGIN      
        1 maarrrrstg ggraralnes krvnngntap edsspakktr rcqrqeskkm pvaggkankd
       61 rtedkqdgmp grswaskrvs esvkalllkg kapvdpecta kvgkahvyce gndvydvmln
      121 qtnlqfnnnk yyliqlledd aqrnfsvwmr wgrvgkmgqh slvacsgnln kakeifqkkf
      181 ldktknnwed rekfekvpgk ydmlqmdyat ntqdeeetkk eeslksplkp esqldlrvqe
      241 liklicnvqa meemmmemky ntkkaplgkl tvaqikagyq slkkiedcir agqhgralme
      301 acnefytrip hdfglrtppl irtqkelsek iqllealgdi eiaiklvkte lqspehpldq
      361 hyrnlhcalr pldhesyefk visqylqsth apthsdytmt lldlfevekd gekeafredl
      421 hnrmllwhgs rmsnwvgils hglriappea pitgymfgkg iyfadmssks anycfasrlk
      481 ntgllllsee weysairtsk
//
LOCUS       XP_016876401             487 aa            linear   PRI 05-AUG-2025
DEFINITION  poly [ADP-ribose] polymerase 2 isoform X2 [Homo sapiens].
ACCESSION   XP_016876401
VERSION     XP_016876401.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020912.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..487
                     /product="poly [ADP-ribose] polymerase 2 isoform X2"
                     /calculated_mol_wt=55706
     Region          19..78
                     /region_name="PARP2_NTR"
                     /note="NTR (N-terminal region) domain of poly [ADP-ribose]
                     polymerase 2 (PARP-2) and similar proteins; cd22252"
                     /db_xref="CDD:412075"
     Site            order(20..24,32..41)
                     /site_type="other"
                     /note="importin alpha binding site [polypeptide binding]"
                     /db_xref="CDD:412075"
     Region          52..476
                     /region_name="PLN03124"
                     /note="poly [ADP-ribose] polymerase; Provisional"
                     /db_xref="CDD:215591"
     CDS             1..487
                     /gene="PARP2"
                     /gene_synonym="ADPRT2; ADPRTL2; ADPRTL3; ARTD2; pADPRT-2;
                     PARP-2"
                     /coded_by="XM_017020912.2:8..1471"
                     /db_xref="GeneID:10038"
                     /db_xref="HGNC:HGNC:272"
                     /db_xref="MIM:607725"
ORIGIN      
        1 maarrrrstg ggraralnes krvnngntap edsspakktr rcqrqeskkm pvaggkankd
       61 rtedkqdesv kalllkgkap vdpectakvg kahvycegnd vydvmlnqtn lqfnnnkyyl
      121 iqlleddaqr nfsvwmrwgr vgkmgqhslv acsgnlnkak eifqkkfldk tknnwedrek
      181 fekvpgkydm lqmdyatntq deeetkkees lksplkpesq ldlrvqelik licnvqamee
      241 mmmemkyntk kaplgkltva qikagyqslk kiedciragq hgralmeacn efytriphdf
      301 glrtpplirt qkelsekiql lealgdieia iklvktelqs pehpldqhyr nlhcalrpld
      361 hesyefkvis qylqsthapt hsdytmtlld lfevekdgek eafredlhnr mllwhgsrms
      421 nwvgilshgl riappeapit gymfgkgiyf admssksany cfasrlkntg llllseewey
      481 sairtsk
//
LOCUS       XP_047286825             285 aa            linear   PRI 05-AUG-2025
DEFINITION  poly [ADP-ribose] polymerase 2 isoform X3 [Homo sapiens].
ACCESSION   XP_047286825
VERSION     XP_047286825.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430869.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..285
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..285
                     /product="poly [ADP-ribose] polymerase 2 isoform X3"
                     /calculated_mol_wt=32195
     Region          1..278
                     /region_name="parp_like"
                     /note="Poly(ADP-ribose) polymerase (parp) catalytic domain
                     catalyses the covalent attachment of ADP-ribose units from
                     NAD+ to itself and to a limited number of other DNA
                     binding proteins, which decreases their affinity for DNA.
                     Poly(ADP-ribose) polymerase is a...; cd01437"
                     /db_xref="CDD:238717"
     Site            order(37,40..41,130..131,136,146..148,164..166,172,175,
                     260)
                     /site_type="active"
                     /note="Inhibitor contact residues [active]"
                     /db_xref="CDD:238717"
     Site            order(37,41,130..132,140,144..146,164,172,175,260)
                     /site_type="other"
                     /note="nad+ contact residues [chemical binding]"
                     /db_xref="CDD:238717"
     CDS             1..285
                     /gene="PARP2"
                     /gene_synonym="ADPRT2; ADPRTL2; ADPRTL3; ARTD2; pADPRT-2;
                     PARP-2"
                     /coded_by="XM_047430869.1:168..1025"
                     /db_xref="GeneID:10038"
                     /db_xref="HGNC:HGNC:272"
                     /db_xref="MIM:607725"
ORIGIN      
        1 meacnefytr iphdfglrtp plirtqkels ekiqllealg dieiaiklvk telqspehpl
       61 dqhyrnlhca lrpldhesye fkvisqylqs thapthsdyt mtlldlfeve kdgekeafre
      121 dlhnrmllwh gsrmsnwvgi lshglriapp eapitgymfg kgiyfadmss ksanycfasr
      181 lkntglllls evalgqcnel leanpkaegl lqgkhstkgl gkmapssahf vtlngstvpl
      241 gpasdtgiln pdgytlnyne yivynpnqvr mryllkvqfn flqlw
//
LOCUS       XP_011534618             250 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase RNF212B isoform X1 [Homo sapiens].
ACCESSION   XP_011534618
VERSION     XP_011534618.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536316.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..250
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..250
                     /product="E3 ubiquitin-protein ligase RNF212B isoform X1"
                     /calculated_mol_wt=28140
     Region          4..40
                     /region_name="RING-HC_RNF212B"
                     /note="RING finger, HC subclass, found in RING finger
                     protein 212B (RNF212B) and similar proteins; cd16747"
                     /db_xref="CDD:438405"
     Region          94..151
                     /region_name="SlyX"
                     /note="pfam04102"
                     /db_xref="CDD:461173"
     CDS             1..250
                     /gene="RNF212B"
                     /gene_synonym="C14orf164"
                     /coded_by="XM_011536316.3:234..986"
                     /db_xref="GeneID:100507650"
                     /db_xref="HGNC:HGNC:20438"
                     /db_xref="MIM:621020"
ORIGIN      
        1 mdwfhcnqcf rkdgahffvt scghifckkc vtlekcavcg tackhlalsd nlkpqekmff
       61 kspvetalqy fshisqvwsf qkkqtdllia fykhritkle tamqeaqqal vsqdkelsvl
      121 rkengelkkf lailkespsr yqgsrsitpr pvgitspsqs vtprpsfqhs sqvvrtssas
      181 sgqgifsfrp spnghsghtr vltpnnfaqr estttleslp sfqlpvlqtl yqqrrhmglp
      241 sgreawttsr
//
LOCUS       XP_011534621             243 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase RNF212B isoform X2 [Homo sapiens].
ACCESSION   XP_011534621
VERSION     XP_011534621.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536319.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..243
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..243
                     /product="E3 ubiquitin-protein ligase RNF212B isoform X2"
                     /calculated_mol_wt=26977
     CDS             1..243
                     /gene="RNF212B"
                     /gene_synonym="C14orf164"
                     /coded_by="XM_011536319.3:192..923"
                     /db_xref="GeneID:100507650"
                     /db_xref="HGNC:HGNC:20438"
                     /db_xref="MIM:621020"
ORIGIN      
        1 mffkspveta lqyfshisqv wsfqkkqtdl liafykhrit kletamqeaq qalvsqdkel
       61 svlrkengel kkflailkes psryqgsrsi tprpvgitsp sqsvtprpsf qhssqvvsrs
      121 ssaesipyre agfgslgqgg rglqgrrtpr dsynetpspa sthslsyrts sassgqgifs
      181 frpspnghsg htrvltpnnf aqrestttle slpsfqlpvl qtlyqqrrhm glpsgreawt
      241 tsr
//
LOCUS       XP_011534625             232 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase RNF212B isoform X3 [Homo sapiens].
ACCESSION   XP_011534625
VERSION     XP_011534625.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536323.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..232
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..232
                     /product="E3 ubiquitin-protein ligase RNF212B isoform X3"
                     /calculated_mol_wt=26122
     Region          4..40
                     /region_name="RING-HC_RNF212B"
                     /note="RING finger, HC subclass, found in RING finger
                     protein 212B (RNF212B) and similar proteins; cd16747"
                     /db_xref="CDD:438405"
     Region          94..151
                     /region_name="SlyX"
                     /note="pfam04102"
                     /db_xref="CDD:461173"
     CDS             1..232
                     /gene="RNF212B"
                     /gene_synonym="C14orf164"
                     /coded_by="XM_011536323.3:234..932"
                     /db_xref="GeneID:100507650"
                     /db_xref="HGNC:HGNC:20438"
                     /db_xref="MIM:621020"
ORIGIN      
        1 mdwfhcnqcf rkdgahffvt scghifckkc vtlekcavcg tackhlalsd nlkpqekmff
       61 kspvetalqy fshisqvwsf qkkqtdllia fykhritkle tamqeaqqal vsqdkelsvl
      121 rkengelkkf lailkespsr yqgsrsitpr pvgitspsqs vtprpsfqhs sqvvsrsssa
      181 esipyreagf gslgqggrgl qgrrtprdsy ndslptteay gitqwersmd hf
//
LOCUS       XP_011534629             208 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase RNF212B isoform X4 [Homo sapiens].
ACCESSION   XP_011534629
VERSION     XP_011534629.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536327.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..208
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..208
                     /product="E3 ubiquitin-protein ligase RNF212B isoform X4"
                     /calculated_mol_wt=23858
     Region          4..40
                     /region_name="RING-HC_RNF212B"
                     /note="RING finger, HC subclass, found in RING finger
                     protein 212B (RNF212B) and similar proteins; cd16747"
                     /db_xref="CDD:438405"
     CDS             1..208
                     /gene="RNF212B"
                     /gene_synonym="C14orf164"
                     /coded_by="XM_011536327.3:234..860"
                     /db_xref="GeneID:100507650"
                     /db_xref="HGNC:HGNC:20438"
                     /db_xref="MIM:621020"
ORIGIN      
        1 mdwfhcnqcf rkdgahffvt scghifckkc vtlekcavcg tackhlalsd nlkpqekmff
       61 kspvetalqy fshisqvwsf qkkqtdllia fykhritkle tamqeaqqal vsqdkelsvl
      121 rkengelkkf lailklphdp vssiavkwsv gppqrnlfli erlalvawdk eaevcregel
      181 petlimtlyq qrrhmglpsg reawttsr
//
LOCUS       XP_011534630             198 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase RNF212B isoform X5 [Homo sapiens].
ACCESSION   XP_011534630
VERSION     XP_011534630.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536328.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..198
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..198
                     /product="E3 ubiquitin-protein ligase RNF212B isoform X5"
                     /calculated_mol_wt=21587
     CDS             1..198
                     /gene="RNF212B"
                     /gene_synonym="C14orf164"
                     /coded_by="XM_011536328.3:330..926"
                     /db_xref="GeneID:100507650"
                     /db_xref="HGNC:HGNC:20438"
                     /db_xref="MIM:621020"
ORIGIN      
        1 mqeaqqalvs qdkelsvlrk engelkkfla ilkespsryq gsrsitprpv gitspsqsvt
       61 prpsfqhssq vvsrsssaes ipyreagfgs lgqggrglqg rrtprdsyne tpspasthsl
      121 syrtssassg qgifsfrpsp nghsghtrvl tpnnfaqres tttleslpsf qlpvlqtlyq
      181 qrrhmglpsg reawttsr
//
LOCUS       XP_005267306             280 aa            linear   PRI 05-AUG-2025
DEFINITION  dehydrogenase/reductase SDR family member 2, mitochondrial isoform
            X1 [Homo sapiens].
ACCESSION   XP_005267306
VERSION     XP_005267306.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267249.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..280
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..280
                     /product="dehydrogenase/reductase SDR family member 2,
                     mitochondrial isoform X1"
                     /calculated_mol_wt=29796
     Region          27..275
                     /region_name="Rossmann-fold NAD(P)(+)-binding proteins"
                     /note="A large family of proteins that share a
                     Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The
                     NADB domain is found in numerous dehydrogenases of
                     metabolic pathways such as glycolysis, and many other
                     redox enzymes. NAD binding involves numerous...; cl21454"
                     /db_xref="CDD:473865"
     Site            order(43,45..46,48,67..69,120..122,170..172,185,189,
                     215..218)
                     /site_type="other"
                     /note="NAD(P) binding site [chemical binding]"
                     /db_xref="CDD:187641"
     Site            order(145,172,185,189)
                     /site_type="active"
                     /db_xref="CDD:187641"
     CDS             1..280
                     /gene="DHRS2"
                     /gene_synonym="HEP27; SDR25C1"
                     /coded_by="XM_005267249.1:160..1002"
                     /db_xref="GeneID:10202"
                     /db_xref="HGNC:HGNC:18349"
                     /db_xref="MIM:615194"
ORIGIN      
        1 mlsavargyq gwfhpcarls vrmsstgidr kgvlanrvav vtgstsgigf aiarrlardg
       61 ahvvissrkq qnvdramakl qgeglsvagi vchvgkaedr eqlvakaleh cggvdflvcs
      121 agvnplvgst lgtseqiwdk ilsvnvkspa lllsqllpym enrrgavilv ssiaaynpvv
      181 algvynvskt allgltrtla lelapkdirv ncvvpgiikt dfskvfhgne slwknfkehh
      241 qlqrigesed cagivsflcs pdasyvngen iavagystrl
//
LOCUS       XP_006720064             280 aa            linear   PRI 05-AUG-2025
DEFINITION  dehydrogenase/reductase SDR family member 2, mitochondrial isoform
            X1 [Homo sapiens].
ACCESSION   XP_006720064
VERSION     XP_006720064.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720001.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..280
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..280
                     /product="dehydrogenase/reductase SDR family member 2,
                     mitochondrial isoform X1"
                     /calculated_mol_wt=29796
     Region          27..275
                     /region_name="Rossmann-fold NAD(P)(+)-binding proteins"
                     /note="A large family of proteins that share a
                     Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The
                     NADB domain is found in numerous dehydrogenases of
                     metabolic pathways such as glycolysis, and many other
                     redox enzymes. NAD binding involves numerous...; cl21454"
                     /db_xref="CDD:473865"
     Site            order(43,45..46,48,67..69,120..122,170..172,185,189,
                     215..218)
                     /site_type="other"
                     /note="NAD(P) binding site [chemical binding]"
                     /db_xref="CDD:187641"
     Site            order(145,172,185,189)
                     /site_type="active"
                     /db_xref="CDD:187641"
     CDS             1..280
                     /gene="DHRS2"
                     /gene_synonym="HEP27; SDR25C1"
                     /coded_by="XM_006720001.4:148..990"
                     /db_xref="GeneID:10202"
                     /db_xref="HGNC:HGNC:18349"
                     /db_xref="MIM:615194"
ORIGIN      
        1 mlsavargyq gwfhpcarls vrmsstgidr kgvlanrvav vtgstsgigf aiarrlardg
       61 ahvvissrkq qnvdramakl qgeglsvagi vchvgkaedr eqlvakaleh cggvdflvcs
      121 agvnplvgst lgtseqiwdk ilsvnvkspa lllsqllpym enrrgavilv ssiaaynpvv
      181 algvynvskt allgltrtla lelapkdirv ncvvpgiikt dfskvfhgne slwknfkehh
      241 qlqrigesed cagivsflcs pdasyvngen iavagystrl
//
LOCUS       XP_047286830             280 aa            linear   PRI 05-AUG-2025
DEFINITION  dehydrogenase/reductase SDR family member 2, mitochondrial isoform
            X1 [Homo sapiens].
ACCESSION   XP_047286830
VERSION     XP_047286830.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430874.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..280
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..280
                     /product="dehydrogenase/reductase SDR family member 2,
                     mitochondrial isoform X1"
                     /calculated_mol_wt=29796
     Region          27..275
                     /region_name="Rossmann-fold NAD(P)(+)-binding proteins"
                     /note="A large family of proteins that share a
                     Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The
                     NADB domain is found in numerous dehydrogenases of
                     metabolic pathways such as glycolysis, and many other
                     redox enzymes. NAD binding involves numerous...; cl21454"
                     /db_xref="CDD:473865"
     Site            order(43,45..46,48,67..69,120..122,170..172,185,189,
                     215..218)
                     /site_type="other"
                     /note="NAD(P) binding site [chemical binding]"
                     /db_xref="CDD:187641"
     Site            order(145,172,185,189)
                     /site_type="active"
                     /db_xref="CDD:187641"
     CDS             1..280
                     /gene="DHRS2"
                     /gene_synonym="HEP27; SDR25C1"
                     /coded_by="XM_047430874.1:63..905"
                     /db_xref="GeneID:10202"
                     /db_xref="HGNC:HGNC:18349"
                     /db_xref="MIM:615194"
ORIGIN      
        1 mlsavargyq gwfhpcarls vrmsstgidr kgvlanrvav vtgstsgigf aiarrlardg
       61 ahvvissrkq qnvdramakl qgeglsvagi vchvgkaedr eqlvakaleh cggvdflvcs
      121 agvnplvgst lgtseqiwdk ilsvnvkspa lllsqllpym enrrgavilv ssiaaynpvv
      181 algvynvskt allgltrtla lelapkdirv ncvvpgiikt dfskvfhgne slwknfkehh
      241 qlqrigesed cagivsflcs pdasyvngen iavagystrl
//
LOCUS       XP_011534640             204 aa            linear   PRI 05-AUG-2025
DEFINITION  dehydrogenase/reductase SDR family member 2, mitochondrial isoform
            X2 [Homo sapiens].
ACCESSION   XP_011534640
VERSION     XP_011534640.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536338.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..204
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..204
                     /product="dehydrogenase/reductase SDR family member 2,
                     mitochondrial isoform X2"
                     /calculated_mol_wt=21674
     Region          1..199
                     /region_name="Rossmann-fold NAD(P)(+)-binding proteins"
                     /note="A large family of proteins that share a
                     Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The
                     NADB domain is found in numerous dehydrogenases of
                     metabolic pathways such as glycolysis, and many other
                     redox enzymes. NAD binding involves numerous...; cl21454"
                     /db_xref="CDD:473865"
     Site            order(69,96,109,113)
                     /site_type="active"
                     /db_xref="CDD:187641"
     CDS             1..204
                     /gene="DHRS2"
                     /gene_synonym="HEP27; SDR25C1"
                     /coded_by="XM_011536338.2:498..1112"
                     /db_xref="GeneID:10202"
                     /db_xref="HGNC:HGNC:18349"
                     /db_xref="MIM:615194"
ORIGIN      
        1 maklqgegls vagivchvgk aedreqlvak alehcggvdf lvcsagvnpl vgstlgtseq
       61 iwdkilsvnv kspalllsql lpymenrrga vilvssiaay npvvalgvyn vsktallglt
      121 rtlalelapk dirvncvvpg iiktdfskvf hgneslwknf kehhqlqrig esedcagivs
      181 flcspdasyv ngeniavagy strl
//
LOCUS       XP_011534641             204 aa            linear   PRI 05-AUG-2025
DEFINITION  dehydrogenase/reductase SDR family member 2, mitochondrial isoform
            X2 [Homo sapiens].
ACCESSION   XP_011534641
VERSION     XP_011534641.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536339.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..204
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..204
                     /product="dehydrogenase/reductase SDR family member 2,
                     mitochondrial isoform X2"
                     /calculated_mol_wt=21674
     Region          1..199
                     /region_name="Rossmann-fold NAD(P)(+)-binding proteins"
                     /note="A large family of proteins that share a
                     Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The
                     NADB domain is found in numerous dehydrogenases of
                     metabolic pathways such as glycolysis, and many other
                     redox enzymes. NAD binding involves numerous...; cl21454"
                     /db_xref="CDD:473865"
     Site            order(69,96,109,113)
                     /site_type="active"
                     /db_xref="CDD:187641"
     CDS             1..204
                     /gene="DHRS2"
                     /gene_synonym="HEP27; SDR25C1"
                     /coded_by="XM_011536339.3:210..824"
                     /db_xref="GeneID:10202"
                     /db_xref="HGNC:HGNC:18349"
                     /db_xref="MIM:615194"
ORIGIN      
        1 maklqgegls vagivchvgk aedreqlvak alehcggvdf lvcsagvnpl vgstlgtseq
       61 iwdkilsvnv kspalllsql lpymenrrga vilvssiaay npvvalgvyn vsktallglt
      121 rtlalelapk dirvncvvpg iiktdfskvf hgneslwknf kehhqlqrig esedcagivs
      181 flcspdasyv ngeniavagy strl
//
LOCUS       XP_011534642             825 aa            linear   PRI 05-AUG-2025
DEFINITION  gephyrin isoform X1 [Homo sapiens].
ACCESSION   XP_011534642
VERSION     XP_011534642.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536340.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..825
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..825
                     /product="gephyrin isoform X1"
                     /calculated_mol_wt=89692
     Region          15..182
                     /region_name="MogA_MoaB"
                     /note="MogA_MoaB family. Members of this family are
                     involved in biosynthesis of the molybdenum cofactor (MoCF)
                     an essential cofactor of a diverse group of redox enzymes.
                     MoCF biosynthesis is an evolutionarily conserved pathway
                     present in eubacteria, archaea; cd00886"
                     /db_xref="CDD:238451"
     Site            order(87..89,132,158..159,163,166)
                     /site_type="active"
                     /note="MPT binding site [active]"
                     /db_xref="CDD:238451"
     Site            order(89,91..92,94,98,119..121,126,129..130,140,143,182)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:238451"
     Region          416..822
                     /region_name="MoeA"
                     /note="MoeA family. Members of this family are involved in
                     biosynthesis of the molybdenum cofactor (MoCF), an
                     essential cofactor of a diverse group of redox enzymes.
                     MoCF biosynthesis is an evolutionarily conserved pathway
                     present in eubacteria, archaea and...; cd00887"
                     /db_xref="CDD:238452"
     Site            order(437,552,567..570,572,575..576,578,612,614,617,746,
                     787,818)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:238452"
     Site            order(595..596,598,638,662)
                     /site_type="active"
                     /note="putative functional site [active]"
                     /db_xref="CDD:238452"
     Site            order(662..664,714..715,719,722)
                     /site_type="active"
                     /note="putative MPT binding site [active]"
                     /db_xref="CDD:238452"
     CDS             1..825
                     /gene="GPHN"
                     /gene_synonym="GEPH; GPH; GPHRYN; HKPX1; MOCODC"
                     /coded_by="XM_011536340.4:382..2859"
                     /db_xref="GeneID:10243"
                     /db_xref="HGNC:HGNC:15465"
                     /db_xref="MIM:603930"
ORIGIN      
        1 mategmiltn hdhqirvgvl tvsdscfrnl aedrsginlk dlvqdpsllg gtisaykivp
       61 deieeiketl idwcdekeln lilttggtgf aprdvtpekf ptfpfcglqk gatkeviere
      121 apgmalamlm gslnvtplgm lsrpvcgirg ktliinlpgs kkgsqecfqf ilpalphaid
      181 llrdaivkvk evhdeledlp spppplsppp ttsphkqted kgvqceeeee ekkdsgvast
      241 edsssshita aaiaakkhpf ytspavvmah geqpipglin yshhstderi pdsiisrgvq
      301 vlprdtasls ttpsespraq atsrlstasc ptpkqirrpd eskgvasrvg slklhrklee
      361 lrdhlegnvk gyslrvnvqs rcsskenilr ashsavditk varrhrmspf pltsmdkafi
      421 tvlemtpvlg teiinyrdgm grvlaqdvya kdnlppfpas vkdgyavraa dgpgdrfiig
      481 esqageqptq tvmpgqvmrv ttgapipcga davvqvedte liresddgte elevrilvqa
      541 rpgqdirpig hdikrgecvl akgthmgpse igllatvgvt evevnkfpvv avmstgnell
      601 npeddllpgk irdsnrstll atiqehgypt inlgivgdnp ddllnalneg isradviits
      661 ggvsmgekdy lkqvldidlh aqihfgrvfm kpglpttfat ldidgvrkii falpgnpvsa
      721 vvtcnlfvvp alrkmqgild prptiikarl scdvkldprp eyhrciltwh hqeplpwaqs
      781 tgnqmssrlm smrsangllm lppkteqyve lhkgevvdvm vigrl
//
LOCUS       XP_016876402             822 aa            linear   PRI 05-AUG-2025
DEFINITION  gephyrin isoform X2 [Homo sapiens].
ACCESSION   XP_016876402
VERSION     XP_016876402.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020913.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..822
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..822
                     /product="gephyrin isoform X2"
                     /calculated_mol_wt=89443
     Region          15..182
                     /region_name="MogA_MoaB"
                     /note="MogA_MoaB family. Members of this family are
                     involved in biosynthesis of the molybdenum cofactor (MoCF)
                     an essential cofactor of a diverse group of redox enzymes.
                     MoCF biosynthesis is an evolutionarily conserved pathway
                     present in eubacteria, archaea; cd00886"
                     /db_xref="CDD:238451"
     Site            order(87..89,132,158..159,163,166)
                     /site_type="active"
                     /note="MPT binding site [active]"
                     /db_xref="CDD:238451"
     Site            order(89,91..92,94,98,119..121,126,129..130,140,143,182)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:238451"
     Region          413..819
                     /region_name="MoeA"
                     /note="MoeA family. Members of this family are involved in
                     biosynthesis of the molybdenum cofactor (MoCF), an
                     essential cofactor of a diverse group of redox enzymes.
                     MoCF biosynthesis is an evolutionarily conserved pathway
                     present in eubacteria, archaea and...; cd00887"
                     /db_xref="CDD:238452"
     Site            order(434,549,564..567,569,572..573,575,609,611,614,743,
                     784,815)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:238452"
     Site            order(592..593,595,635,659)
                     /site_type="active"
                     /note="putative functional site [active]"
                     /db_xref="CDD:238452"
     Site            order(659..661,711..712,716,719)
                     /site_type="active"
                     /note="putative MPT binding site [active]"
                     /db_xref="CDD:238452"
     CDS             1..822
                     /gene="GPHN"
                     /gene_synonym="GEPH; GPH; GPHRYN; HKPX1; MOCODC"
                     /coded_by="XM_017020913.3:382..2850"
                     /db_xref="GeneID:10243"
                     /db_xref="HGNC:HGNC:15465"
                     /db_xref="MIM:603930"
ORIGIN      
        1 mategmiltn hdhqirvgvl tvsdscfrnl aedrsginlk dlvqdpsllg gtisaykivp
       61 deieeiketl idwcdekeln lilttggtgf aprdvtpekf ptfpfcglqk gatkeviere
      121 apgmalamlm gslnvtplgm lsrpvcgirg ktliinlpgs kkgsqecfqf ilpalphaid
      181 llrdaivkvk evhdeledlp spppplsppp ttsphkqted kgvqceeeee ekkdsgvast
      241 edsssshita aaiaakkhpf ytspavvmah geqpipglin yshhstderi pdsiisrgvq
      301 vlprdtasls ttpsespraq atsrlstasc ptpkqirrpd eskgvasrvg slklhsrleg
      361 lkdelwrnrg ydlrvqsrcs skenilrash savditkvar rhrmspfplt smdkafitvl
      421 emtpvlgtei inyrdgmgrv laqdvyakdn lppfpasvkd gyavraadgp gdrfiigesq
      481 ageqptqtvm pgqvmrvttg apipcgadav vqvedtelir esddgteele vrilvqarpg
      541 qdirpighdi krgecvlakg thmgpseigl latvgvteve vnkfpvvavm stgnellnpe
      601 ddllpgkird snrstllati qehgyptinl givgdnpddl lnalnegisr adviitsggv
      661 smgekdylkq vldidlhaqi hfgrvfmkpg lpttfatldi dgvrkiifal pgnpvsavvt
      721 cnlfvvpalr kmqgildprp tiikarlscd vkldprpeyh rciltwhhqe plpwaqstgn
      781 qmssrlmsmr sangllmlpp kteqyvelhk gevvdvmvig rl
//
LOCUS       XP_011534644             812 aa            linear   PRI 05-AUG-2025
DEFINITION  gephyrin isoform X3 [Homo sapiens].
ACCESSION   XP_011534644
VERSION     XP_011534644.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536342.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..812
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..812
                     /product="gephyrin isoform X3"
                     /calculated_mol_wt=88240
     Region          15..169
                     /region_name="MogA_MoaB"
                     /note="MogA_MoaB family. Members of this family are
                     involved in biosynthesis of the molybdenum cofactor (MoCF)
                     an essential cofactor of a diverse group of redox enzymes.
                     MoCF biosynthesis is an evolutionarily conserved pathway
                     present in eubacteria, archaea; cd00886"
                     /db_xref="CDD:238451"
     Site            order(87..89,119,145..146,150,153)
                     /site_type="active"
                     /note="MPT binding site [active]"
                     /db_xref="CDD:238451"
     Site            order(89,91..92,94,98,106..108,113,116..117,127,130,169)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:238451"
     Region          403..809
                     /region_name="MoeA"
                     /note="MoeA family. Members of this family are involved in
                     biosynthesis of the molybdenum cofactor (MoCF), an
                     essential cofactor of a diverse group of redox enzymes.
                     MoCF biosynthesis is an evolutionarily conserved pathway
                     present in eubacteria, archaea and...; cd00887"
                     /db_xref="CDD:238452"
     Site            order(424,539,554..557,559,562..563,565,599,601,604,733,
                     774,805)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:238452"
     Site            order(582..583,585,625,649)
                     /site_type="active"
                     /note="putative functional site [active]"
                     /db_xref="CDD:238452"
     Site            order(649..651,701..702,706,709)
                     /site_type="active"
                     /note="putative MPT binding site [active]"
                     /db_xref="CDD:238452"
     CDS             1..812
                     /gene="GPHN"
                     /gene_synonym="GEPH; GPH; GPHRYN; HKPX1; MOCODC"
                     /coded_by="XM_011536342.4:382..2820"
                     /db_xref="GeneID:10243"
                     /db_xref="HGNC:HGNC:15465"
                     /db_xref="MIM:603930"
ORIGIN      
        1 mategmiltn hdhqirvgvl tvsdscfrnl aedrsginlk dlvqdpsllg gtisaykivp
       61 deieeiketl idwcdekeln lilttggtgf aprdvtpeat keviereapg malamlmgsl
      121 nvtplgmlsr pvcgirgktl iinlpgskkg sqecfqfilp alphaidllr daivkvkevh
      181 deledlpspp pplsppptts phkqtedkgv qceeeeeekk dsgvasteds ssshitaaai
      241 aakkhpfyts pavvmahgeq pipglinysh hstderipds iisrgvqvlp rdtaslsttp
      301 sespraqats rlstascptp kqirrpdesk gvasrvgslk lhrkleelrd hlegnvkgys
      361 lrvnvqsrcs skenilrash savditkvar rhrmspfplt smdkafitvl emtpvlgtei
      421 inyrdgmgrv laqdvyakdn lppfpasvkd gyavraadgp gdrfiigesq ageqptqtvm
      481 pgqvmrvttg apipcgadav vqvedtelir esddgteele vrilvqarpg qdirpighdi
      541 krgecvlakg thmgpseigl latvgvteve vnkfpvvavm stgnellnpe ddllpgkird
      601 snrstllati qehgyptinl givgdnpddl lnalnegisr adviitsggv smgekdylkq
      661 vldidlhaqi hfgrvfmkpg lpttfatldi dgvrkiifal pgnpvsavvt cnlfvvpalr
      721 kmqgildprp tiikarlscd vkldprpeyh rciltwhhqe plpwaqstgn qmssrlmsmr
      781 sangllmlpp kteqyvelhk gevvdvmvig rl
//
LOCUS       XP_016876403             806 aa            linear   PRI 05-AUG-2025
DEFINITION  gephyrin isoform X4 [Homo sapiens].
ACCESSION   XP_016876403
VERSION     XP_016876403.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020914.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..806
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..806
                     /product="gephyrin isoform X4"
                     /calculated_mol_wt=87627
     Region          15..182
                     /region_name="MogA_MoaB"
                     /note="MogA_MoaB family. Members of this family are
                     involved in biosynthesis of the molybdenum cofactor (MoCF)
                     an essential cofactor of a diverse group of redox enzymes.
                     MoCF biosynthesis is an evolutionarily conserved pathway
                     present in eubacteria, archaea; cd00886"
                     /db_xref="CDD:238451"
     Site            order(87..89,132,158..159,163,166)
                     /site_type="active"
                     /note="MPT binding site [active]"
                     /db_xref="CDD:238451"
     Site            order(89,91..92,94,98,119..121,126,129..130,140,143,182)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:238451"
     Region          397..803
                     /region_name="MoeA"
                     /note="MoeA family. Members of this family are involved in
                     biosynthesis of the molybdenum cofactor (MoCF), an
                     essential cofactor of a diverse group of redox enzymes.
                     MoCF biosynthesis is an evolutionarily conserved pathway
                     present in eubacteria, archaea and...; cd00887"
                     /db_xref="CDD:238452"
     Site            order(418,533,548..551,553,556..557,559,593,595,598,727,
                     768,799)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:238452"
     Site            order(576..577,579,619,643)
                     /site_type="active"
                     /note="putative functional site [active]"
                     /db_xref="CDD:238452"
     Site            order(643..645,695..696,700,703)
                     /site_type="active"
                     /note="putative MPT binding site [active]"
                     /db_xref="CDD:238452"
     CDS             1..806
                     /gene="GPHN"
                     /gene_synonym="GEPH; GPH; GPHRYN; HKPX1; MOCODC"
                     /coded_by="XM_017020914.3:382..2802"
                     /db_xref="GeneID:10243"
                     /db_xref="HGNC:HGNC:15465"
                     /db_xref="MIM:603930"
ORIGIN      
        1 mategmiltn hdhqirvgvl tvsdscfrnl aedrsginlk dlvqdpsllg gtisaykivp
       61 deieeiketl idwcdekeln lilttggtgf aprdvtpekf ptfpfcglqk gatkeviere
      121 apgmalamlm gslnvtplgm lsrpvcgirg ktliinlpgs kkgsqecfqf ilpalphaid
      181 llrdaivkvk evhdeledlp spppplsppp ttsphkqted kgvqceeeee ekkdsgvast
      241 edsssshita aaiaakkhpf ytspavvmah geqpipglin yshhstderi pdsiisrgvq
      301 vlprdtasls ttpsespraq atsrlstasc ptpklhrkle elrdhlegnv kgyslrvnvq
      361 srcsskenil rashsavdit kvarrhrmsp fpltsmdkaf itvlemtpvl gteiinyrdg
      421 mgrvlaqdvy akdnlppfpa svkdgyavra adgpgdrfii gesqageqpt qtvmpgqvmr
      481 vttgapipcg adavvqvedt eliresddgt eelevrilvq arpgqdirpi ghdikrgecv
      541 lakgthmgps eigllatvgv tevevnkfpv vavmstgnel lnpeddllpg kirdsnrstl
      601 latiqehgyp tinlgivgdn pddllnalne gisradviit sggvsmgekd ylkqvldidl
      661 haqihfgrvf mkpglpttfa tldidgvrki ifalpgnpvs avvtcnlfvv palrkmqgil
      721 dprptiikar lscdvkldpr peyhrciltw hhqeplpwaq stgnqmssrl msmrsangll
      781 mlppkteqyv elhkgevvdv mvigrl
//
LOCUS       XP_011534645             801 aa            linear   PRI 05-AUG-2025
DEFINITION  gephyrin isoform X5 [Homo sapiens].
ACCESSION   XP_011534645
VERSION     XP_011534645.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536343.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..801
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..801
                     /product="gephyrin isoform X5"
                     /calculated_mol_wt=86834
     Region          15..182
                     /region_name="MogA_MoaB"
                     /note="MogA_MoaB family. Members of this family are
                     involved in biosynthesis of the molybdenum cofactor (MoCF)
                     an essential cofactor of a diverse group of redox enzymes.
                     MoCF biosynthesis is an evolutionarily conserved pathway
                     present in eubacteria, archaea; cd00886"
                     /db_xref="CDD:238451"
     Site            order(87..89,132,158..159,163,166)
                     /site_type="active"
                     /note="MPT binding site [active]"
                     /db_xref="CDD:238451"
     Site            order(89,91..92,94,98,119..121,126,129..130,140,143,182)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:238451"
     Region          392..798
                     /region_name="MoeA"
                     /note="MoeA family. Members of this family are involved in
                     biosynthesis of the molybdenum cofactor (MoCF), an
                     essential cofactor of a diverse group of redox enzymes.
                     MoCF biosynthesis is an evolutionarily conserved pathway
                     present in eubacteria, archaea and...; cd00887"
                     /db_xref="CDD:238452"
     Site            order(413,528,543..546,548,551..552,554,588,590,593,722,
                     763,794)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:238452"
     Site            order(571..572,574,614,638)
                     /site_type="active"
                     /note="putative functional site [active]"
                     /db_xref="CDD:238452"
     Site            order(638..640,690..691,695,698)
                     /site_type="active"
                     /note="putative MPT binding site [active]"
                     /db_xref="CDD:238452"
     CDS             1..801
                     /gene="GPHN"
                     /gene_synonym="GEPH; GPH; GPHRYN; HKPX1; MOCODC"
                     /coded_by="XM_011536343.4:382..2787"
                     /db_xref="GeneID:10243"
                     /db_xref="HGNC:HGNC:15465"
                     /db_xref="MIM:603930"
ORIGIN      
        1 mategmiltn hdhqirvgvl tvsdscfrnl aedrsginlk dlvqdpsllg gtisaykivp
       61 deieeiketl idwcdekeln lilttggtgf aprdvtpekf ptfpfcglqk gatkeviere
      121 apgmalamlm gslnvtplgm lsrpvcgirg ktliinlpgs kkgsqecfqf ilpalphaid
      181 llrdaivkvk evhdeledlp spppplsppp ttsphkqted kgvqceeeee ekkdsgvast
      241 edsssshita aaiaakkhpf ytspavvmah geqpipglin yshhstderi pdsiisrgvq
      301 vlprdtasls ttpsespraq atsrlstasc ptpkqirrpd eskgvasrvg slkvqsrcss
      361 kenilrashs avditkvarr hrmspfplts mdkafitvle mtpvlgteii nyrdgmgrvl
      421 aqdvyakdnl ppfpasvkdg yavraadgpg drfiigesqa geqptqtvmp gqvmrvttga
      481 pipcgadavv qvedtelire sddgteelev rilvqarpgq dirpighdik rgecvlakgt
      541 hmgpseigll atvgvtevev nkfpvvavms tgnellnped dllpgkirds nrstllatiq
      601 ehgyptinlg ivgdnpddll nalnegisra dviitsggvs mgekdylkqv ldidlhaqih
      661 fgrvfmkpgl pttfatldid gvrkiifalp gnpvsavvtc nlfvvpalrk mqgildprpt
      721 iikarlscdv kldprpeyhr ciltwhhqep lpwaqstgnq mssrlmsmrs angllmlppk
      781 teqyvelhkg evvdvmvigr l
//
LOCUS       XP_047286831             793 aa            linear   PRI 05-AUG-2025
DEFINITION  gephyrin isoform X6 [Homo sapiens].
ACCESSION   XP_047286831
VERSION     XP_047286831.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430875.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..793
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..793
                     /product="gephyrin isoform X6"
                     /calculated_mol_wt=86175
     Region          15..169
                     /region_name="MogA_MoaB"
                     /note="MogA_MoaB family. Members of this family are
                     involved in biosynthesis of the molybdenum cofactor (MoCF)
                     an essential cofactor of a diverse group of redox enzymes.
                     MoCF biosynthesis is an evolutionarily conserved pathway
                     present in eubacteria, archaea; cd00886"
                     /db_xref="CDD:238451"
     Site            order(87..89,119,145..146,150,153)
                     /site_type="active"
                     /note="MPT binding site [active]"
                     /db_xref="CDD:238451"
     Site            order(89,91..92,94,98,106..108,113,116..117,127,130,169)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:238451"
     Region          384..790
                     /region_name="MoeA"
                     /note="MoeA family. Members of this family are involved in
                     biosynthesis of the molybdenum cofactor (MoCF), an
                     essential cofactor of a diverse group of redox enzymes.
                     MoCF biosynthesis is an evolutionarily conserved pathway
                     present in eubacteria, archaea and...; cd00887"
                     /db_xref="CDD:238452"
     Site            order(405,520,535..538,540,543..544,546,580,582,585,714,
                     755,786)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:238452"
     Site            order(563..564,566,606,630)
                     /site_type="active"
                     /note="putative functional site [active]"
                     /db_xref="CDD:238452"
     Site            order(630..632,682..683,687,690)
                     /site_type="active"
                     /note="putative MPT binding site [active]"
                     /db_xref="CDD:238452"
     CDS             1..793
                     /gene="GPHN"
                     /gene_synonym="GEPH; GPH; GPHRYN; HKPX1; MOCODC"
                     /coded_by="XM_047430875.1:382..2763"
                     /db_xref="GeneID:10243"
                     /db_xref="HGNC:HGNC:15465"
                     /db_xref="MIM:603930"
ORIGIN      
        1 mategmiltn hdhqirvgvl tvsdscfrnl aedrsginlk dlvqdpsllg gtisaykivp
       61 deieeiketl idwcdekeln lilttggtgf aprdvtpeat keviereapg malamlmgsl
      121 nvtplgmlsr pvcgirgktl iinlpgskkg sqecfqfilp alphaidllr daivkvkevh
      181 deledlpspp pplsppptts phkqtedkgv qceeeeeekk dsgvasteds ssshitaaai
      241 aakkhpfyts pavvmahgeq pipglinysh hstderipds iisrgvqvlp rdtaslsttp
      301 sespraqats rlstascptp klhrkleelr dhlegnvkgy slrvnvqsrc sskenilras
      361 hsavditkva rrhrmspfpl tsmdkafitv lemtpvlgte iinyrdgmgr vlaqdvyakd
      421 nlppfpasvk dgyavraadg pgdrfiiges qageqptqtv mpgqvmrvtt gapipcgada
      481 vvqvedteli resddgteel evrilvqarp gqdirpighd ikrgecvlak gthmgpseig
      541 llatvgvtev evnkfpvvav mstgnellnp eddllpgkir dsnrstllat iqehgyptin
      601 lgivgdnpdd llnalnegis radviitsgg vsmgekdylk qvldidlhaq ihfgrvfmkp
      661 glpttfatld idgvrkiifa lpgnpvsavv tcnlfvvpal rkmqgildpr ptiikarlsc
      721 dvkldprpey hrciltwhhq eplpwaqstg nqmssrlmsm rsangllmlp pkteqyvelh
      781 kgevvdvmvi grl
//
LOCUS       XP_011534646             792 aa            linear   PRI 05-AUG-2025
DEFINITION  gephyrin isoform X7 [Homo sapiens].
ACCESSION   XP_011534646
VERSION     XP_011534646.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536344.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..792
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..792
                     /product="gephyrin isoform X7"
                     /calculated_mol_wt=85993
     Region          15..182
                     /region_name="MogA_MoaB"
                     /note="MogA_MoaB family. Members of this family are
                     involved in biosynthesis of the molybdenum cofactor (MoCF)
                     an essential cofactor of a diverse group of redox enzymes.
                     MoCF biosynthesis is an evolutionarily conserved pathway
                     present in eubacteria, archaea; cd00886"
                     /db_xref="CDD:238451"
     Site            order(87..89,132,158..159,163,166)
                     /site_type="active"
                     /note="MPT binding site [active]"
                     /db_xref="CDD:238451"
     Site            order(89,91..92,94,98,119..121,126,129..130,140,143,182)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:238451"
     Region          383..789
                     /region_name="MoeA"
                     /note="MoeA family. Members of this family are involved in
                     biosynthesis of the molybdenum cofactor (MoCF), an
                     essential cofactor of a diverse group of redox enzymes.
                     MoCF biosynthesis is an evolutionarily conserved pathway
                     present in eubacteria, archaea and...; cd00887"
                     /db_xref="CDD:238452"
     Site            order(404,519,534..537,539,542..543,545,579,581,584,713,
                     754,785)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:238452"
     Site            order(562..563,565,605,629)
                     /site_type="active"
                     /note="putative functional site [active]"
                     /db_xref="CDD:238452"
     Site            order(629..631,681..682,686,689)
                     /site_type="active"
                     /note="putative MPT binding site [active]"
                     /db_xref="CDD:238452"
     CDS             1..792
                     /gene="GPHN"
                     /gene_synonym="GEPH; GPH; GPHRYN; HKPX1; MOCODC"
                     /coded_by="XM_011536344.4:382..2760"
                     /db_xref="GeneID:10243"
                     /db_xref="HGNC:HGNC:15465"
                     /db_xref="MIM:603930"
ORIGIN      
        1 mategmiltn hdhqirvgvl tvsdscfrnl aedrsginlk dlvqdpsllg gtisaykivp
       61 deieeiketl idwcdekeln lilttggtgf aprdvtpekf ptfpfcglqk gatkeviere
      121 apgmalamlm gslnvtplgm lsrpvcgirg ktliinlpgs kkgsqecfqf ilpalphaid
      181 llrdaivkvk evhdeledlp spppplsppp ttsphkqted kgvqceeeee ekkdsgvast
      241 edsssshita aaiaakipds iisrgvqvlp rdtaslsttp sespraqats rlstascptp
      301 kqirrpdesk gvasrvgslk lhrkleelrd hlegnvkgys lrvnvqsrcs skenilrash
      361 savditkvar rhrmspfplt smdkafitvl emtpvlgtei inyrdgmgrv laqdvyakdn
      421 lppfpasvkd gyavraadgp gdrfiigesq ageqptqtvm pgqvmrvttg apipcgadav
      481 vqvedtelir esddgteele vrilvqarpg qdirpighdi krgecvlakg thmgpseigl
      541 latvgvteve vnkfpvvavm stgnellnpe ddllpgkird snrstllati qehgyptinl
      601 givgdnpddl lnalnegisr adviitsggv smgekdylkq vldidlhaqi hfgrvfmkpg
      661 lpttfatldi dgvrkiifal pgnpvsavvt cnlfvvpalr kmqgildprp tiikarlscd
      721 vkldprpeyh rciltwhhqe plpwaqstgn qmssrlmsmr sangllmlpp kteqyvelhk
      781 gevvdvmvig rl
//
LOCUS       XP_047286832             788 aa            linear   PRI 05-AUG-2025
DEFINITION  gephyrin isoform X8 [Homo sapiens].
ACCESSION   XP_047286832
VERSION     XP_047286832.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430876.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..788
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..788
                     /product="gephyrin isoform X8"
                     /calculated_mol_wt=85382
     Region          15..169
                     /region_name="MogA_MoaB"
                     /note="MogA_MoaB family. Members of this family are
                     involved in biosynthesis of the molybdenum cofactor (MoCF)
                     an essential cofactor of a diverse group of redox enzymes.
                     MoCF biosynthesis is an evolutionarily conserved pathway
                     present in eubacteria, archaea; cd00886"
                     /db_xref="CDD:238451"
     Site            order(87..89,119,145..146,150,153)
                     /site_type="active"
                     /note="MPT binding site [active]"
                     /db_xref="CDD:238451"
     Site            order(89,91..92,94,98,106..108,113,116..117,127,130,169)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:238451"
     Region          379..785
                     /region_name="MoeA"
                     /note="MoeA family. Members of this family are involved in
                     biosynthesis of the molybdenum cofactor (MoCF), an
                     essential cofactor of a diverse group of redox enzymes.
                     MoCF biosynthesis is an evolutionarily conserved pathway
                     present in eubacteria, archaea and...; cd00887"
                     /db_xref="CDD:238452"
     Site            order(400,515,530..533,535,538..539,541,575,577,580,709,
                     750,781)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:238452"
     Site            order(558..559,561,601,625)
                     /site_type="active"
                     /note="putative functional site [active]"
                     /db_xref="CDD:238452"
     Site            order(625..627,677..678,682,685)
                     /site_type="active"
                     /note="putative MPT binding site [active]"
                     /db_xref="CDD:238452"
     CDS             1..788
                     /gene="GPHN"
                     /gene_synonym="GEPH; GPH; GPHRYN; HKPX1; MOCODC"
                     /coded_by="XM_047430876.1:382..2748"
                     /db_xref="GeneID:10243"
                     /db_xref="HGNC:HGNC:15465"
                     /db_xref="MIM:603930"
ORIGIN      
        1 mategmiltn hdhqirvgvl tvsdscfrnl aedrsginlk dlvqdpsllg gtisaykivp
       61 deieeiketl idwcdekeln lilttggtgf aprdvtpeat keviereapg malamlmgsl
      121 nvtplgmlsr pvcgirgktl iinlpgskkg sqecfqfilp alphaidllr daivkvkevh
      181 deledlpspp pplsppptts phkqtedkgv qceeeeeekk dsgvasteds ssshitaaai
      241 aakkhpfyts pavvmahgeq pipglinysh hstderipds iisrgvqvlp rdtaslsttp
      301 sespraqats rlstascptp kqirrpdesk gvasrvgslk vqsrcssken ilrashsavd
      361 itkvarrhrm spfpltsmdk afitvlemtp vlgteiinyr dgmgrvlaqd vyakdnlppf
      421 pasvkdgyav raadgpgdrf iigesqageq ptqtvmpgqv mrvttgapip cgadavvqve
      481 dteliresdd gteelevril vqarpgqdir pighdikrge cvlakgthmg pseigllatv
      541 gvtevevnkf pvvavmstgn ellnpeddll pgkirdsnrs tllatiqehg yptinlgivg
      601 dnpddllnal negisradvi itsggvsmge kdylkqvldi dlhaqihfgr vfmkpglptt
      661 fatldidgvr kiifalpgnp vsavvtcnlf vvpalrkmqg ildprptiik arlscdvkld
      721 prpeyhrcil twhhqeplpw aqstgnqmss rlmsmrsang llmlppkteq yvelhkgevv
      781 dvmvigrl
//
LOCUS       XP_011534647             782 aa            linear   PRI 05-AUG-2025
DEFINITION  gephyrin isoform X9 [Homo sapiens].
ACCESSION   XP_011534647
VERSION     XP_011534647.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536345.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..782
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..782
                     /product="gephyrin isoform X9"
                     /calculated_mol_wt=84769
     Region          15..182
                     /region_name="MogA_MoaB"
                     /note="MogA_MoaB family. Members of this family are
                     involved in biosynthesis of the molybdenum cofactor (MoCF)
                     an essential cofactor of a diverse group of redox enzymes.
                     MoCF biosynthesis is an evolutionarily conserved pathway
                     present in eubacteria, archaea; cd00886"
                     /db_xref="CDD:238451"
     Site            order(87..89,132,158..159,163,166)
                     /site_type="active"
                     /note="MPT binding site [active]"
                     /db_xref="CDD:238451"
     Site            order(89,91..92,94,98,119..121,126,129..130,140,143,182)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:238451"
     Region          373..779
                     /region_name="MoeA"
                     /note="MoeA family. Members of this family are involved in
                     biosynthesis of the molybdenum cofactor (MoCF), an
                     essential cofactor of a diverse group of redox enzymes.
                     MoCF biosynthesis is an evolutionarily conserved pathway
                     present in eubacteria, archaea and...; cd00887"
                     /db_xref="CDD:238452"
     Site            order(394,509,524..527,529,532..533,535,569,571,574,703,
                     744,775)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:238452"
     Site            order(552..553,555,595,619)
                     /site_type="active"
                     /note="putative functional site [active]"
                     /db_xref="CDD:238452"
     Site            order(619..621,671..672,676,679)
                     /site_type="active"
                     /note="putative MPT binding site [active]"
                     /db_xref="CDD:238452"
     CDS             1..782
                     /gene="GPHN"
                     /gene_synonym="GEPH; GPH; GPHRYN; HKPX1; MOCODC"
                     /coded_by="XM_011536345.4:382..2730"
                     /db_xref="GeneID:10243"
                     /db_xref="HGNC:HGNC:15465"
                     /db_xref="MIM:603930"
ORIGIN      
        1 mategmiltn hdhqirvgvl tvsdscfrnl aedrsginlk dlvqdpsllg gtisaykivp
       61 deieeiketl idwcdekeln lilttggtgf aprdvtpekf ptfpfcglqk gatkeviere
      121 apgmalamlm gslnvtplgm lsrpvcgirg ktliinlpgs kkgsqecfqf ilpalphaid
      181 llrdaivkvk evhdeledlp spppplsppp ttsphkqted kgvqceeeee ekkdsgvast
      241 edsssshita aaiaakkhpf ytspavvmah geqpipglin yshhstderi pdsiisrgvq
      301 vlprdtasls ttpsespraq atsrlstasc ptpkvqsrcs skenilrash savditkvar
      361 rhrmspfplt smdkafitvl emtpvlgtei inyrdgmgrv laqdvyakdn lppfpasvkd
      421 gyavraadgp gdrfiigesq ageqptqtvm pgqvmrvttg apipcgadav vqvedtelir
      481 esddgteele vrilvqarpg qdirpighdi krgecvlakg thmgpseigl latvgvteve
      541 vnkfpvvavm stgnellnpe ddllpgkird snrstllati qehgyptinl givgdnpddl
      601 lnalnegisr adviitsggv smgekdylkq vldidlhaqi hfgrvfmkpg lpttfatldi
      661 dgvrkiifal pgnpvsavvt cnlfvvpalr kmqgildprp tiikarlscd vkldprpeyh
      721 rciltwhhqe plpwaqstgn qmssrlmsmr sangllmlpp kteqyvelhk gevvdvmvig
      781 rl
//
LOCUS       XP_016876406             773 aa            linear   PRI 05-AUG-2025
DEFINITION  gephyrin isoform X10 [Homo sapiens].
ACCESSION   XP_016876406
VERSION     XP_016876406.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020917.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..773
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..773
                     /product="gephyrin isoform X10"
                     /calculated_mol_wt=83928
     Region          15..182
                     /region_name="MogA_MoaB"
                     /note="MogA_MoaB family. Members of this family are
                     involved in biosynthesis of the molybdenum cofactor (MoCF)
                     an essential cofactor of a diverse group of redox enzymes.
                     MoCF biosynthesis is an evolutionarily conserved pathway
                     present in eubacteria, archaea; cd00886"
                     /db_xref="CDD:238451"
     Site            order(87..89,132,158..159,163,166)
                     /site_type="active"
                     /note="MPT binding site [active]"
                     /db_xref="CDD:238451"
     Site            order(89,91..92,94,98,119..121,126,129..130,140,143,182)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:238451"
     Region          364..770
                     /region_name="MoeA"
                     /note="MoeA family. Members of this family are involved in
                     biosynthesis of the molybdenum cofactor (MoCF), an
                     essential cofactor of a diverse group of redox enzymes.
                     MoCF biosynthesis is an evolutionarily conserved pathway
                     present in eubacteria, archaea and...; cd00887"
                     /db_xref="CDD:238452"
     Site            order(385,500,515..518,520,523..524,526,560,562,565,694,
                     735,766)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:238452"
     Site            order(543..544,546,586,610)
                     /site_type="active"
                     /note="putative functional site [active]"
                     /db_xref="CDD:238452"
     Site            order(610..612,662..663,667,670)
                     /site_type="active"
                     /note="putative MPT binding site [active]"
                     /db_xref="CDD:238452"
     CDS             1..773
                     /gene="GPHN"
                     /gene_synonym="GEPH; GPH; GPHRYN; HKPX1; MOCODC"
                     /coded_by="XM_017020917.3:382..2703"
                     /db_xref="GeneID:10243"
                     /db_xref="HGNC:HGNC:15465"
                     /db_xref="MIM:603930"
ORIGIN      
        1 mategmiltn hdhqirvgvl tvsdscfrnl aedrsginlk dlvqdpsllg gtisaykivp
       61 deieeiketl idwcdekeln lilttggtgf aprdvtpekf ptfpfcglqk gatkeviere
      121 apgmalamlm gslnvtplgm lsrpvcgirg ktliinlpgs kkgsqecfqf ilpalphaid
      181 llrdaivkvk evhdeledlp spppplsppp ttsphkqted kgvqceeeee ekkdsgvast
      241 edsssshita aaiaakipds iisrgvqvlp rdtaslsttp sespraqats rlstascptp
      301 klhrkleelr dhlegnvkgy slrvnvqsrc sskenilras hsavditkva rrhrmspfpl
      361 tsmdkafitv lemtpvlgte iinyrdgmgr vlaqdvyakd nlppfpasvk dgyavraadg
      421 pgdrfiiges qageqptqtv mpgqvmrvtt gapipcgada vvqvedteli resddgteel
      481 evrilvqarp gqdirpighd ikrgecvlak gthmgpseig llatvgvtev evnkfpvvav
      541 mstgnellnp eddllpgkir dsnrstllat iqehgyptin lgivgdnpdd llnalnegis
      601 radviitsgg vsmgekdylk qvldidlhaq ihfgrvfmkp glpttfatld idgvrkiifa
      661 lpgnpvsavv tcnlfvvpal rkmqgildpr ptiikarlsc dvkldprpey hrciltwhhq
      721 eplpwaqstg nqmssrlmsm rsangllmlp pkteqyvelh kgevvdvmvi grl
//
LOCUS       XP_016876407             768 aa            linear   PRI 05-AUG-2025
DEFINITION  gephyrin isoform X11 [Homo sapiens].
ACCESSION   XP_016876407
VERSION     XP_016876407.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020918.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..768
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..768
                     /product="gephyrin isoform X11"
                     /calculated_mol_wt=83135
     Region          15..182
                     /region_name="MogA_MoaB"
                     /note="MogA_MoaB family. Members of this family are
                     involved in biosynthesis of the molybdenum cofactor (MoCF)
                     an essential cofactor of a diverse group of redox enzymes.
                     MoCF biosynthesis is an evolutionarily conserved pathway
                     present in eubacteria, archaea; cd00886"
                     /db_xref="CDD:238451"
     Site            order(87..89,132,158..159,163,166)
                     /site_type="active"
                     /note="MPT binding site [active]"
                     /db_xref="CDD:238451"
     Site            order(89,91..92,94,98,119..121,126,129..130,140,143,182)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:238451"
     Region          359..765
                     /region_name="MoeA"
                     /note="MoeA family. Members of this family are involved in
                     biosynthesis of the molybdenum cofactor (MoCF), an
                     essential cofactor of a diverse group of redox enzymes.
                     MoCF biosynthesis is an evolutionarily conserved pathway
                     present in eubacteria, archaea and...; cd00887"
                     /db_xref="CDD:238452"
     Site            order(380,495,510..513,515,518..519,521,555,557,560,689,
                     730,761)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:238452"
     Site            order(538..539,541,581,605)
                     /site_type="active"
                     /note="putative functional site [active]"
                     /db_xref="CDD:238452"
     Site            order(605..607,657..658,662,665)
                     /site_type="active"
                     /note="putative MPT binding site [active]"
                     /db_xref="CDD:238452"
     CDS             1..768
                     /gene="GPHN"
                     /gene_synonym="GEPH; GPH; GPHRYN; HKPX1; MOCODC"
                     /coded_by="XM_017020918.3:382..2688"
                     /db_xref="GeneID:10243"
                     /db_xref="HGNC:HGNC:15465"
                     /db_xref="MIM:603930"
ORIGIN      
        1 mategmiltn hdhqirvgvl tvsdscfrnl aedrsginlk dlvqdpsllg gtisaykivp
       61 deieeiketl idwcdekeln lilttggtgf aprdvtpekf ptfpfcglqk gatkeviere
      121 apgmalamlm gslnvtplgm lsrpvcgirg ktliinlpgs kkgsqecfqf ilpalphaid
      181 llrdaivkvk evhdeledlp spppplsppp ttsphkqted kgvqceeeee ekkdsgvast
      241 edsssshita aaiaakipds iisrgvqvlp rdtaslsttp sespraqats rlstascptp
      301 kqirrpdesk gvasrvgslk vqsrcssken ilrashsavd itkvarrhrm spfpltsmdk
      361 afitvlemtp vlgteiinyr dgmgrvlaqd vyakdnlppf pasvkdgyav raadgpgdrf
      421 iigesqageq ptqtvmpgqv mrvttgapip cgadavvqve dteliresdd gteelevril
      481 vqarpgqdir pighdikrge cvlakgthmg pseigllatv gvtevevnkf pvvavmstgn
      541 ellnpeddll pgkirdsnrs tllatiqehg yptinlgivg dnpddllnal negisradvi
      601 itsggvsmge kdylkqvldi dlhaqihfgr vfmkpglptt fatldidgvr kiifalpgnp
      661 vsavvtcnlf vvpalrkmqg ildprptiik arlscdvkld prpeyhrcil twhhqeplpw
      721 aqstgnqmss rlmsmrsang llmlppkteq yvelhkgevv dvmvigrl
//
LOCUS       XP_047286833             486 aa            linear   PRI 05-AUG-2025
DEFINITION  gephyrin isoform X12 [Homo sapiens].
ACCESSION   XP_047286833
VERSION     XP_047286833.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430877.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..486
                     /product="gephyrin isoform X12"
                     /calculated_mol_wt=53106
     Region          77..483
                     /region_name="MoeA"
                     /note="MoeA family. Members of this family are involved in
                     biosynthesis of the molybdenum cofactor (MoCF), an
                     essential cofactor of a diverse group of redox enzymes.
                     MoCF biosynthesis is an evolutionarily conserved pathway
                     present in eubacteria, archaea and...; cd00887"
                     /db_xref="CDD:238452"
     Site            order(98,213,228..231,233,236..237,239,273,275,278,407,
                     448,479)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:238452"
     Site            order(256..257,259,299,323)
                     /site_type="active"
                     /note="putative functional site [active]"
                     /db_xref="CDD:238452"
     Site            order(323..325,375..376,380,383)
                     /site_type="active"
                     /note="putative MPT binding site [active]"
                     /db_xref="CDD:238452"
     CDS             1..486
                     /gene="GPHN"
                     /gene_synonym="GEPH; GPH; GPHRYN; HKPX1; MOCODC"
                     /coded_by="XM_047430877.1:214..1674"
                     /db_xref="GeneID:10243"
                     /db_xref="HGNC:HGNC:15465"
                     /db_xref="MIM:603930"
ORIGIN      
        1 mapqtterat aslqlhrkle elrdhlegnv kgyslrvnvq srcsskenil rashsavdit
       61 kvarrhrmsp fpltsmdkaf itvlemtpvl gteiinyrdg mgrvlaqdvy akdnlppfpa
      121 svkdgyavra adgpgdrfii gesqageqpt qtvmpgqvmr vttgapipcg adavvqvedt
      181 eliresddgt eelevrilvq arpgqdirpi ghdikrgecv lakgthmgps eigllatvgv
      241 tevevnkfpv vavmstgnel lnpeddllpg kirdsnrstl latiqehgyp tinlgivgdn
      301 pddllnalne gisradviit sggvsmgekd ylkqvldidl haqihfgrvf mkpglpttfa
      361 tldidgvrki ifalpgnpvs avvtcnlfvv palrkmqgil dprptiikar lscdvkldpr
      421 peyhrciltw hhqeplpwaq stgnqmssrl msmrsangll mlppkteqyv elhkgevvdv
      481 mvigrl
//
LOCUS       XP_047286834             486 aa            linear   PRI 05-AUG-2025
DEFINITION  gephyrin isoform X12 [Homo sapiens].
ACCESSION   XP_047286834
VERSION     XP_047286834.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430878.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..486
                     /product="gephyrin isoform X12"
                     /calculated_mol_wt=53106
     Region          77..483
                     /region_name="MoeA"
                     /note="MoeA family. Members of this family are involved in
                     biosynthesis of the molybdenum cofactor (MoCF), an
                     essential cofactor of a diverse group of redox enzymes.
                     MoCF biosynthesis is an evolutionarily conserved pathway
                     present in eubacteria, archaea and...; cd00887"
                     /db_xref="CDD:238452"
     Site            order(98,213,228..231,233,236..237,239,273,275,278,407,
                     448,479)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:238452"
     Site            order(256..257,259,299,323)
                     /site_type="active"
                     /note="putative functional site [active]"
                     /db_xref="CDD:238452"
     Site            order(323..325,375..376,380,383)
                     /site_type="active"
                     /note="putative MPT binding site [active]"
                     /db_xref="CDD:238452"
     CDS             1..486
                     /gene="GPHN"
                     /gene_synonym="GEPH; GPH; GPHRYN; HKPX1; MOCODC"
                     /coded_by="XM_047430878.1:102..1562"
                     /db_xref="GeneID:10243"
                     /db_xref="HGNC:HGNC:15465"
                     /db_xref="MIM:603930"
ORIGIN      
        1 mapqtterat aslqlhrkle elrdhlegnv kgyslrvnvq srcsskenil rashsavdit
       61 kvarrhrmsp fpltsmdkaf itvlemtpvl gteiinyrdg mgrvlaqdvy akdnlppfpa
      121 svkdgyavra adgpgdrfii gesqageqpt qtvmpgqvmr vttgapipcg adavvqvedt
      181 eliresddgt eelevrilvq arpgqdirpi ghdikrgecv lakgthmgps eigllatvgv
      241 tevevnkfpv vavmstgnel lnpeddllpg kirdsnrstl latiqehgyp tinlgivgdn
      301 pddllnalne gisradviit sggvsmgekd ylkqvldidl haqihfgrvf mkpglpttfa
      361 tldidgvrki ifalpgnpvs avvtcnlfvv palrkmqgil dprptiikar lscdvkldpr
      421 peyhrciltw hhqeplpwaq stgnqmssrl msmrsangll mlppkteqyv elhkgevvdv
      481 mvigrl
//
LOCUS       XP_047286835             485 aa            linear   PRI 05-AUG-2025
DEFINITION  gephyrin isoform X13 [Homo sapiens].
ACCESSION   XP_047286835
VERSION     XP_047286835.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430879.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..485
                     /product="gephyrin isoform X13"
                     /calculated_mol_wt=52977
     Region          15..182
                     /region_name="MogA_MoaB"
                     /note="MogA_MoaB family. Members of this family are
                     involved in biosynthesis of the molybdenum cofactor (MoCF)
                     an essential cofactor of a diverse group of redox enzymes.
                     MoCF biosynthesis is an evolutionarily conserved pathway
                     present in eubacteria, archaea; cd00886"
                     /db_xref="CDD:238451"
     Site            order(87..89,132,158..159,163,166)
                     /site_type="active"
                     /note="MPT binding site [active]"
                     /db_xref="CDD:238451"
     Site            order(89,91..92,94,98,119..121,126,129..130,140,143,182)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:238451"
     CDS             1..485
                     /gene="GPHN"
                     /gene_synonym="GEPH; GPH; GPHRYN; HKPX1; MOCODC"
                     /coded_by="XM_047430879.1:382..1839"
                     /db_xref="GeneID:10243"
                     /db_xref="HGNC:HGNC:15465"
                     /db_xref="MIM:603930"
ORIGIN      
        1 mategmiltn hdhqirvgvl tvsdscfrnl aedrsginlk dlvqdpsllg gtisaykivp
       61 deieeiketl idwcdekeln lilttggtgf aprdvtpekf ptfpfcglqk gatkeviere
      121 apgmalamlm gslnvtplgm lsrpvcgirg ktliinlpgs kkgsqecfqf ilpalphaid
      181 llrdaivkvk evhdeledlp spppplsppp ttsphkqted kgvqceeeee ekkdsgvast
      241 edsssshita aaiaakkhpf ytspavvmah geqpipglin yshhstderi pdsiisrgvq
      301 vlprdtasls ttpsespraq atsrlstasc ptpkqirrpd eskgvasrvg slklhrklee
      361 lrdhlegnvk gyslrvnvqs rcsskenilr ashsavditk varrhrmspf pltsmdkafi
      421 tvlemtpvlg teiinyrdsr lhhfswcsga ptrhslpqhy sfriascsgy isplcsvspd
      481 tkrti
//
LOCUS       XP_047286836             462 aa            linear   PRI 05-AUG-2025
DEFINITION  gephyrin isoform X14 [Homo sapiens].
ACCESSION   XP_047286836
VERSION     XP_047286836.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430880.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..462
                     /product="gephyrin isoform X14"
                     /calculated_mol_wt=50248
     Region          53..459
                     /region_name="MoeA"
                     /note="MoeA family. Members of this family are involved in
                     biosynthesis of the molybdenum cofactor (MoCF), an
                     essential cofactor of a diverse group of redox enzymes.
                     MoCF biosynthesis is an evolutionarily conserved pathway
                     present in eubacteria, archaea and...; cd00887"
                     /db_xref="CDD:238452"
     Site            order(74,189,204..207,209,212..213,215,249,251,254,383,
                     424,455)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:238452"
     Site            order(232..233,235,275,299)
                     /site_type="active"
                     /note="putative functional site [active]"
                     /db_xref="CDD:238452"
     Site            order(299..301,351..352,356,359)
                     /site_type="active"
                     /note="putative MPT binding site [active]"
                     /db_xref="CDD:238452"
     CDS             1..462
                     /gene="GPHN"
                     /gene_synonym="GEPH; GPH; GPHRYN; HKPX1; MOCODC"
                     /coded_by="XM_047430880.1:213..1601"
                     /db_xref="GeneID:10243"
                     /db_xref="HGNC:HGNC:15465"
                     /db_xref="MIM:603930"
ORIGIN      
        1 mapqtterat aslqvqsrcs skenilrash savditkvar rhrmspfplt smdkafitvl
       61 emtpvlgtei inyrdgmgrv laqdvyakdn lppfpasvkd gyavraadgp gdrfiigesq
      121 ageqptqtvm pgqvmrvttg apipcgadav vqvedtelir esddgteele vrilvqarpg
      181 qdirpighdi krgecvlakg thmgpseigl latvgvteve vnkfpvvavm stgnellnpe
      241 ddllpgkird snrstllati qehgyptinl givgdnpddl lnalnegisr adviitsggv
      301 smgekdylkq vldidlhaqi hfgrvfmkpg lpttfatldi dgvrkiifal pgnpvsavvt
      361 cnlfvvpalr kmqgildprp tiikarlscd vkldprpeyh rciltwhhqe plpwaqstgn
      421 qmssrlmsmr sangllmlpp kteqyvelhk gevvdvmvig rl
//
LOCUS       XP_005267313             531 aa            linear   PRI 05-AUG-2025
DEFINITION  embryonal Fyn-associated substrate isoform X1 [Homo sapiens].
ACCESSION   XP_005267313
VERSION     XP_005267313.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267256.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..531
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..531
                     /product="embryonal Fyn-associated substrate isoform X1"
                     /calculated_mol_wt=55565
     Region          8..70
                     /region_name="SH3_EFS"
                     /note="Src homology 3 domain of CAS (Crk-Associated
                     Substrate) scaffolding protein family member, Embryonal
                     Fyn-associated Substrate; cd12003"
                     /db_xref="CDD:212936"
     Site            order(14,16,19,23,45..46,59,61..62)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212936"
     Region          67..>205
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          401..530
                     /region_name="FAT-like_EFS_C"
                     /note="C-terminal FAT-like Four helix bundle domain, also
                     called DUF3513, of CAS (Crk-Associated Substrate)
                     scaffolding protein, Embryonal Fyn-associated Substrate; a
                     protein interaction module; cd11571"
                     /db_xref="CDD:211412"
     Site            order(404,408..409,412,416,445,448..449,452,455..457,
                     459..460,463..464,478..479,482,486,489,493)
                     /site_type="other"
                     /note="NSP binding site [polypeptide binding]"
                     /db_xref="CDD:211412"
     CDS             1..531
                     /gene="EFS"
                     /gene_synonym="CAS3; CASS3; EFS1; EFS2; HEFS; SIN"
                     /coded_by="XM_005267256.3:148..1743"
                     /db_xref="GeneID:10278"
                     /db_xref="HGNC:HGNC:16898"
                     /db_xref="MIM:609906"
ORIGIN      
        1 maiatstqla ralydntaes pqelsfrrgd vlrvlqrega ggldgwclcs lhgqqgivpa
       61 nrvkllpagp apkpslspas paqpgspypa pdhsnedqev yvvppparpc ptsgppagpc
      121 ppspdliyki prasgtqlaa prdalevydv pptalrvpss gpydcpasfs hpltrvapqp
      181 pgeddapydv pltpkppael epdleweggr epgppiyaap snlkrasall nlyeapeell
      241 adgegggtde giydvpllgp eappspeppg alashdqdtl aqllarsppp phrprlpsae
      301 slsrrplpal pvpeapspsp vpspapgrkg siqdrplppp pprlpgyggp kvegdpegre
      361 meddpaghhn eyegipmaee ydyvhlkeal spgeplvvst gdlqllyfya gqcqshysal
      421 qaavaalmss tqanqpprlf vphskrvvva ahrlvfvgdt lgrlaasapl raqvraagta
      481 lgqalratvl avkgaalgyp sspaiqemvq cvtelagqal qfttlltsla p
//
LOCUS       XP_011534657             772 aa            linear   PRI 05-AUG-2025
DEFINITION  protein transport protein Sec23A isoform X2 [Homo sapiens].
ACCESSION   XP_011534657
VERSION     XP_011534657.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536355.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..772
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..772
                     /product="protein transport protein Sec23A isoform X2"
                     /calculated_mol_wt=87232
     Region          12..762
                     /region_name="PLN00162"
                     /note="transport protein sec23; Provisional"
                     /db_xref="CDD:215083"
     CDS             1..772
                     /gene="SEC23A"
                     /gene_synonym="CLSD; hSec23A"
                     /coded_by="XM_011536355.4:226..2544"
                     /db_xref="GeneID:10484"
                     /db_xref="HGNC:HGNC:10701"
                     /db_xref="MIM:610511"
ORIGIN      
        1 mttylefiqq neerdgvrfs wnvwpssrle atrmvvpvaa lftplkerpd lppiqyepvl
       61 csrttcravl nplcqvdyra klwacnfcyq rnqfppsyag iselnqpael lpqfssieyv
      121 vlrgpqmpli flyvvdtcme dedlqalkes mqmslsllpp talvglitfg rmvqvhelgc
      181 egisksyvfr gtkdlsakql qemlglskvp ltqatrgpqv qqpppsnrfl qpvqkidmnl
      241 tdllgelqrd pwpvpqgkrp lrssgvalsi avgllectfp ntgarimmfi ggpatqgpgm
      301 vvgdelktpi rswhdidkdn akyvkkgtkh fealanraat tghvidiyac aldqtgllem
      361 kccpnltggy mvmgdsfnts lfkqtfqrvf tkdmhgqfkm gfggtleikt sreikisgai
      421 gpcvslnskg pcvseneigt ggtcqwkicg lsptttlaiy fevvnqhnap ipqggrgaiq
      481 fvtqyqhssg qrrirvttia rnwadaqtqi qniaasfdqe aaailmarla iyraeteegp
      541 dvlrwldrql irlcqkfgey hkddpssfrf setfslypqr rdfpktsgei lenqekarsa
      601 clkfmfhlrr ssflqvfnns pdessyyrhh fmrqdltqsl imiqpilyay sfsgppepvl
      661 ldsssiladr illmdtffqi liyhgetiaq wrksgyqdmp eyenfrhllq apvddaqeil
      721 hsrfpmpryi dtehggsqar fllskvnpsq thnnmyawgq eihpevfrnk ms
//
LOCUS       XP_016876417             748 aa            linear   PRI 05-AUG-2025
DEFINITION  protein transport protein Sec23A isoform X3 [Homo sapiens].
ACCESSION   XP_016876417
VERSION     XP_016876417.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020928.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..748
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..748
                     /product="protein transport protein Sec23A isoform X3"
                     /calculated_mol_wt=84473
     Region          12..738
                     /region_name="PLN00162"
                     /note="transport protein sec23; Provisional"
                     /db_xref="CDD:215083"
     CDS             1..748
                     /gene="SEC23A"
                     /gene_synonym="CLSD; hSec23A"
                     /coded_by="XM_017020928.3:226..2472"
                     /db_xref="GeneID:10484"
                     /db_xref="HGNC:HGNC:10701"
                     /db_xref="MIM:610511"
ORIGIN      
        1 mttylefiqq neerdgvrfs wnvwpssrle atrmvvpvaa lftplkerpd lppiqyepvl
       61 csrttcravl nplcqvdyra klwacnfcyq rnqfppsyag iselnqpael lpqfssieyv
      121 vlrgpqmpli flyvvdtcme dedlqalkes mqmslsllpp talvglitfg rmvqvhelgc
      181 egisksyvfr gtkdlsakql qemlglskvp ltqatrgpqv qqpppsnrfl qpvqkidmnl
      241 tdllgelqrd pwpvpqgkrp lrssgvalsi avgllectfp ntgarimmfi ggpatqgpgm
      301 vvgdelktpi rswhdidkdn akyvkkgtkh fealanraat tghvidiyac aldqtgllem
      361 kccpnltggy mvmgdsfnts lfkqtfqrvf tkdmhgqfkm gfggtleikt sreikisgai
      421 gpcvslnskg pcvseneigt ggtcqwkicg lsptttlaiy fevvnqhnap ipqggrgaiq
      481 fvtqyqhssg qrrirvttia rnwadaqtqi qniaasfdqe aaailmarla iyraeteegp
      541 dvlrwldrql irlcqkfgey hkddpssfrf setfslypqf mfhlrrssfl qvfnnspdes
      601 syyrhhfmrq dltqslimiq pilyaysfsg ppepvlldss siladrillm dtffqiliyh
      661 getiaqwrks gyqdmpeyen frhllqapvd daqeilhsrf pmpryidteh ggsqarflls
      721 kvnpsqthnn myawgqeihp evfrnkms
//
LOCUS       XP_011534658             481 aa            linear   PRI 05-AUG-2025
DEFINITION  fibulin-5 isoform X1 [Homo sapiens].
ACCESSION   XP_011534658
VERSION     XP_011534658.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536356.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..481
                     /product="fibulin-5 isoform X1"
                     /calculated_mol_wt=53427
     Region          144..175
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF domain; pfam07645"
                     /db_xref="CDD:429571"
     Region          192..222
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          224..262
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain; smart00179"
                     /db_xref="CDD:214542"
     Site            order(224,227,240)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          275..303
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     CDS             1..481
                     /gene="FBLN5"
                     /gene_synonym="ADCL2; ARCL1A; ARMD3; CMT1H; DANCE; EVEC;
                     FIBL-5; HNARMD; UP50"
                     /coded_by="XM_011536356.2:255..1700"
                     /db_xref="GeneID:10516"
                     /db_xref="HGNC:HGNC:3602"
                     /db_xref="MIM:604580"
ORIGIN      
        1 mfvwdshrsf kpmrsgncrq rymiltvtil alclpspgna qaqctngfdl drqsgqcldi
       61 decrtipeac rgdmmcvnqn ggylciprtn pvyrgpysnp ystpysgpyp aaapplsapn
      121 yptisrplic rfgyqmdesn qcvdvdecat dshqcnptqi cinteggytc sctdgywlle
      181 gqcldidecr ygycqqlcan vpgsysctcn pgftlnedgr scqdvnecat enpcvqtcvn
      241 tygsficrcd pgyeleedgv hcsdmdecsf seflcqhecv nqpgtyfcsc ppgyillddn
      301 rscqdinece hrnhtcnlqq tcynlqggfk cidpirceep ylrisdnrcm cpaenpgcrd
      361 qpftilyrdm dvvsgrsvpa difqmqattr ypgayyifqi ksgnegrefy mrrafsttay
      421 eassqalsve kqtgcglcpg gththlsgeg ennlanttqs gdsqvksrpm gckrapsvpp
      481 w
//
LOCUS       XP_011534662             166 aa            linear   PRI 05-AUG-2025
DEFINITION  apoptosis regulatory protein Siva isoform X1 [Homo sapiens].
ACCESSION   XP_011534662
VERSION     XP_011534662.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536360.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..166
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..166
                     /product="apoptosis regulatory protein Siva isoform X1"
                     /calculated_mol_wt=17560
     Region          1..157
                     /region_name="Siva"
                     /note="Cd27 binding protein (Siva); pfam05458"
                     /db_xref="CDD:283184"
     CDS             1..166
                     /gene="SIVA1"
                     /gene_synonym="CD27BP; SIVA; Siva-1; Siva-2"
                     /coded_by="XM_011536360.3:56..556"
                     /db_xref="GeneID:10572"
                     /db_xref="HGNC:HGNC:17712"
                     /db_xref="MIM:605567"
ORIGIN      
        1 mpkrscpfad vaplqlkvrv sqrelsrgvc aerysqevfe ktkrllflga qayldhvwde
       61 gcavvhlpes pkpgptgapr aargqmligp dgrlirslgq aseadpsgva siacsscvra
      121 vdgkavcgqc eralcgqcvr tcwgcgsvac tlcglvdlfr tlvvlp
//
LOCUS       XP_005267329             746 aa            linear   PRI 05-AUG-2025
DEFINITION  exocyst complex component 5 isoform X1 [Homo sapiens].
ACCESSION   XP_005267329
VERSION     XP_005267329.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267272.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..746
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..746
                     /product="exocyst complex component 5 isoform X1"
                     /calculated_mol_wt=85332
     Region          127..745
                     /region_name="Sec10"
                     /note="Exocyst complex component Sec10; pfam07393"
                     /db_xref="CDD:399988"
     CDS             1..746
                     /gene="EXOC5"
                     /gene_synonym="HSEC10; PRO1912; SEC10; SEC10L1; SEC10P"
                     /coded_by="XM_005267272.4:258..2498"
                     /db_xref="GeneID:10640"
                     /db_xref="HGNC:HGNC:10696"
                     /db_xref="MIM:604469"
ORIGIN      
        1 mattaelfev gpggstgsgr pgvcrqlggr aeerafagcp ggalgreepf vadeyierlv
       61 wrtpgggsrg gpeafdpkrl leefvnhiqe lqimderiqr kvekleqqcq keakefakkv
      121 qelqksnqva fqhfqeldeh isyvatkvch lgdqlegvnt prqraveaqk lmkyfnefld
      181 gelksdvftn sekikeaadi iqklhliaqe lpfdrfsevk skiaskyhdl ecqliqefts
      241 aqrrgeisrm revaavllhf kgyshcvdvy ikqcqegayl rndifedagi lcqrvnkqvg
      301 difsnpetvl akliqnvfei klqsfvkeql eecrksdaeq ylknlydlyt rttnlssklm
      361 efnlgtdkqt flskliksif isylenyiev etgylksrsa milqryydsk nhqkrsigtg
      421 giqdlkerir qrtnlplgps idthgetfls qevvvnllqe tkqaferchr lsdpsdlprn
      481 afriftilve flciehidya letglagips sdsrnanlyf ldvvqqanti fhlfdkqfnd
      541 hlmplisssp klseclqkkk eiieqmemkl dtgidrtlnc migqmkhila aeqkktdfkp
      601 edennvliqy tnacvkvcay vrkqvekikn smdgknvdtv lmelgvrfhr liyehlqqys
      661 yscmggmlai cdvaeyrkca kdfkipmvlh lfdtlhalcn llvvapdnlk qvcsgeqlan
      721 ldknilhsfv qlradyrsar larhfs
//
LOCUS       XP_047286838             653 aa            linear   PRI 05-AUG-2025
DEFINITION  exocyst complex component 5 isoform X2 [Homo sapiens].
ACCESSION   XP_047286838
VERSION     XP_047286838.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430882.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..653
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..653
                     /product="exocyst complex component 5 isoform X2"
                     /calculated_mol_wt=75449
     Region          34..652
                     /region_name="Sec10"
                     /note="Exocyst complex component Sec10; pfam07393"
                     /db_xref="CDD:399988"
     CDS             1..653
                     /gene="EXOC5"
                     /gene_synonym="HSEC10; PRO1912; SEC10; SEC10L1; SEC10P"
                     /coded_by="XM_047430882.1:259..2220"
                     /db_xref="GeneID:10640"
                     /db_xref="HGNC:HGNC:10696"
                     /db_xref="MIM:604469"
ORIGIN      
        1 mderiqrkve kleqqcqkea kefakkvqel qksnqvafqh fqeldehisy vatkvchlgd
       61 qlegvntprq raveaqklmk yfnefldgel ksdvftnsek ikeaadiiqk lhliaqelpf
      121 drfsevkski askyhdlecq liqeftsaqr rgeisrmrev aavllhfkgy shcvdvyikq
      181 cqegaylrnd ifedagilcq rvnkqvgdif snpetvlakl iqnvfeiklq sfvkeqleec
      241 rksdaeqylk nlydlytrtt nlssklmefn lgtdkqtfls kliksifisy lenyievetg
      301 ylksrsamil qryydsknhq krsigtggiq dlkerirqrt nlplgpsidt hgetflsqev
      361 vvnllqetkq aferchrlsd psdlprnafr iftilveflc iehidyalet glagipssds
      421 rnanlyfldv vqqantifhl fdkqfndhlm plissspkls eclqkkkeii eqmemkldtg
      481 idrtlncmig qmkhilaaeq kktdfkpede nnvliqytna cvkvcayvrk qvekiknsmd
      541 gknvdtvlme lgvrfhrliy ehlqqysysc mggmlaicdv aeyrkcakdf kipmvlhlfd
      601 tlhalcnllv vapdnlkqvc sgeqlanldk nilhsfvqlr adyrsarlar hfs
//
LOCUS       XP_011534666             490 aa            linear   PRI 05-AUG-2025
DEFINITION  cholesterol 24-hydroxylase isoform X1 [Homo sapiens].
ACCESSION   XP_011534666
VERSION     XP_011534666.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536364.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..490
                     /product="cholesterol 24-hydroxylase isoform X1"
                     /calculated_mol_wt=55643
     Region          61..474
                     /region_name="CYP46A1-like"
                     /note="cytochrome P450 family 46, subfamily A, polypeptide
                     1, also called cholesterol 24-hydroxylase, and similar
                     cytochrome P450s; cd20613"
                     /db_xref="CDD:410706"
     Site            order(80..81,108..111,121,126,222,225,226,302,367..369,
                     371,464..465)
                     /site_type="other"
                     /note="chemical substrate binding pocket [chemical
                     binding]"
                     /db_xref="CDD:410706"
     Site            order(104,109,125..126,134,138,145,192,299,302..303,
                     306..307,310,367,370,419..421,425..429,432..433,436)
                     /site_type="other"
                     /note="heme binding site [chemical binding]"
                     /db_xref="CDD:410706"
     CDS             1..490
                     /gene="CYP46A1"
                     /gene_synonym="CP46; CYP46"
                     /coded_by="XM_011536364.2:121..1593"
                     /db_xref="GeneID:10858"
                     /db_xref="HGNC:HGNC:2641"
                     /db_xref="MIM:604087"
ORIGIN      
        1 mspgllllgs avllafglcc tfvhrarsry ehipgpprps fllghlpcfw kkdevggrvl
       61 qdvfldwakk ygpvvrvnvf hktsvivtsp esvkkflmst kynkdskmyr alqtvfgerl
      121 fgqglvsecn yerwhkqrrv idlafsrssl vslmetfnek aeqlveilea kadgqtpvsm
      181 qdmltytamd ilakaafgme tsmllgaqkp lsqavklmle gitasrntla kflpgkrkql
      241 revresirfl rqvgrdwvqr rrealkrgee vpadiltqil kaeegaqdde glldnfvtff
      301 iaghetsanh laftvmelsr qpeivarlqa evdevigskr yldfedlgrl qylsqvlkes
      361 lrlyppawgt frlleeetli dgfstyvmgr mdtyfedplt fnpdrfgpga pkprftyfpf
      421 slghrscigq qfaqmevkvv makllqrlef rlvpgqrfgl qeqatlkpld pvlctlrprg
      481 wqpapppppc
//
LOCUS       XP_016876422             462 aa            linear   PRI 05-AUG-2025
DEFINITION  cholesterol 24-hydroxylase isoform X2 [Homo sapiens].
ACCESSION   XP_016876422
VERSION     XP_016876422.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020933.3
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 15% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..462
                     /product="cholesterol 24-hydroxylase isoform X2"
                     /calculated_mol_wt=52397
     Region          56..446
                     /region_name="CYP46A1-like"
                     /note="cytochrome P450 family 46, subfamily A, polypeptide
                     1, also called cholesterol 24-hydroxylase, and similar
                     cytochrome P450s; cd20613"
                     /db_xref="CDD:410706"
     Site            order(66,71,87..88,96,100,107,154,261,264..265,268..269,
                     272,329,332,391..393,397..401,404..405,408)
                     /site_type="other"
                     /note="heme binding site [chemical binding]"
                     /db_xref="CDD:410706"
     Site            order(70..73,83,88,184,187,188,264,329..331,333,436..437)
                     /site_type="other"
                     /note="chemical substrate binding pocket [chemical
                     binding]"
                     /db_xref="CDD:410706"
     CDS             1..462
                     /gene="CYP46A1"
                     /gene_synonym="CP46; CYP46"
                     /coded_by="XM_017020933.3:278..1666"
                     /db_xref="GeneID:10858"
                     /db_xref="HGNC:HGNC:2641"
                     /db_xref="MIM:604087"
ORIGIN      
        1 mrlvavcskm cfwiglrsmd llcgstsstk pqsssrvlsr lssislasci lkfcyqkflm
       61 stkynkdskm yralqtvfge rlfgqglvse cnyerwhkqr rvidlafsrs slvslmetfn
      121 ekaeqlveil eakadgqtpv smqdmltyta mdilakaafg metsmllgaq kplsqavklm
      181 legitasrnt lakflpgkrk qlrevresir flrqvgrdwv qrrrealkrg eevpadiltq
      241 ilkaeegaqd deglldnfvt ffiaghetsa nhlaftvmel srqpeivarl qaevdevigs
      301 kryldfedlg rlqylsqvlk eslrlyppaw gtfrlleeet lidgvrvpgn tpllfstyvm
      361 grmdtyfedp ltfnpdrfgp gapkprftyf pfslghrsci gqqfaqmevk vvmakllqrl
      421 efrlvpgqrf glqeqatlkp ldpvlctlrp rgwqpapppp pc
//
LOCUS       XP_005267331             355 aa            linear   PRI 05-AUG-2025
DEFINITION  cholesterol 24-hydroxylase isoform X3 [Homo sapiens].
ACCESSION   XP_005267331
VERSION     XP_005267331.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267274.6
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..355
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..355
                     /product="cholesterol 24-hydroxylase isoform X3"
                     /calculated_mol_wt=40048
     Region          <5..339
                     /region_name="CYP46A1-like"
                     /note="cytochrome P450 family 46, subfamily A, polypeptide
                     1, also called cholesterol 24-hydroxylase, and similar
                     cytochrome P450s; cd20613"
                     /db_xref="CDD:410706"
     CDS             1..355
                     /gene="CYP46A1"
                     /gene_synonym="CP46; CYP46"
                     /coded_by="XM_005267274.6:100..1167"
                     /db_xref="GeneID:10858"
                     /db_xref="HGNC:HGNC:2641"
                     /db_xref="MIM:604087"
ORIGIN      
        1 mnaslvslme tfnekaeqlv eileakadgq tpvsmqdmlt ytamdilaka afgmetsmll
       61 gaqkplsqav klmlegitas rntlakflpg krkqlrevre sirflrqvgr dwvqrrreal
      121 krgeevpadi ltqilkaeeg aqddeglldn fvtffiaghe tsanhlaftv melsrqpeiv
      181 arlqaevdev igskryldfe dlgrlqylsq vlkeslrlyp pawgtfrlle eetlidgvrv
      241 pgntpllfst yvmgrmdtyf edpltfnpdr fgpgapkprf tyfpfslghr scigqqfaqm
      301 evkvvmakll qrlefrlvpg qrfglqeqat lkpldpvlct lrprgwqpap ppppc
//
LOCUS       XP_011534667             347 aa            linear   PRI 05-AUG-2025
DEFINITION  cholesterol 24-hydroxylase isoform X4 [Homo sapiens].
ACCESSION   XP_011534667
VERSION     XP_011534667.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536365.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..347
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..347
                     /product="cholesterol 24-hydroxylase isoform X4"
                     /calculated_mol_wt=39232
     Region          <1..331
                     /region_name="cytochrome_P450"
                     /note="cytochrome P450 (CYP) superfamily; cl41757"
                     /db_xref="CDD:477761"
     Site            order(39,145..146,149..150,153..154,157,208,217,219,242,
                     276..278,282..286,289..290)
                     /site_type="other"
                     /note="heme binding site [chemical binding]"
                     /db_xref="CDD:410706"
     Site            order(65..66,145,148..149,153,215..218)
                     /site_type="other"
                     /note="chemical substrate binding pocket [chemical
                     binding]"
                     /db_xref="CDD:410706"
     CDS             1..347
                     /gene="CYP46A1"
                     /gene_synonym="CP46; CYP46"
                     /coded_by="XM_011536365.3:785..1828"
                     /db_xref="GeneID:10858"
                     /db_xref="HGNC:HGNC:2641"
                     /db_xref="MIM:604087"
ORIGIN      
        1 metfnekaeq lveileakad gqtpvsmqdm ltytamdila kaafgmetsm llgaqkplsq
       61 avklmlegit asrntlakfl pgkrkqlrev resirflrqv grdwvqrrre alkrgeevpa
      121 diltqilkae egaqddegll dnfvtffiag hetsanhlaf tvmelsrqpe ivarlqaevd
      181 evigskryld fedlgrlqyl sqvlkeslrl yppawgtfrl leeetlidgv rvpgntpllf
      241 styvmgrmdt yfedpltfnp drfgpgapkp rftyfpfslg hrscigqqfa qmevkvvmak
      301 llqrlefrlv pgqrfglqeq atlkpldpvl ctlrprgwqp apppppc
//
LOCUS       XP_016876423             147 aa            linear   PRI 05-AUG-2025
DEFINITION  epididymal secretory protein E3-alpha isoform X1 [Homo sapiens].
ACCESSION   XP_016876423
VERSION     XP_016876423.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020934.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..147
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..147
                     /product="epididymal secretory protein E3-alpha isoform
                     X1"
                     /calculated_mol_wt=17515
     CDS             1..147
                     /gene="EDDM3A"
                     /gene_synonym="EP3A; FAM12A; HE3-ALPHA; HE3A; HE3ALPHA;
                     RAM1"
                     /coded_by="XM_017020934.3:97..540"
                     /db_xref="GeneID:10876"
                     /db_xref="HGNC:HGNC:16978"
                     /db_xref="MIM:611580"
ORIGIN      
        1 mtsslkiwgi llallcilcr lcvysnniyw refiklhyls psrefkeykc dvlmrekeal
       61 kgksfhmfiy slwfkiqrac inekgsdryr nayvwapgal kvlechweky nnrytesrsf
      121 syiefhcgvd gyvdniedlr iiepisn
//
LOCUS       XP_011534668             142 aa            linear   PRI 05-AUG-2025
DEFINITION  dehydrogenase/reductase SDR family member 4 isoform X1 [Homo
            sapiens].
ACCESSION   XP_011534668
VERSION     XP_011534668.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536366.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..142
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..142
                     /product="dehydrogenase/reductase SDR family member 4
                     isoform X1"
                     /calculated_mol_wt=14985
     Region          23..>138
                     /region_name="Rossmann-fold NAD(P)(+)-binding proteins"
                     /note="A large family of proteins that share a
                     Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The
                     NADB domain is found in numerous dehydrogenases of
                     metabolic pathways such as glycolysis, and many other
                     redox enzymes. NAD binding involves numerous...; cl21454"
                     /db_xref="CDD:473865"
     CDS             1..142
                     /gene="DHRS4"
                     /gene_synonym="CR; NRDR; PHCR; PSCD; SCAD-SRL; SDR-SRL;
                     SDR25C1; SDR25C2"
                     /coded_by="XM_011536366.3:20..448"
                     /db_xref="GeneID:10901"
                     /db_xref="HGNC:HGNC:16985"
                     /db_xref="MIM:611596"
ORIGIN      
        1 mhkagllglc arawnsvrma ssgmtrrdpl ankvalvtas tdgigfaiar rlaqdgahvv
       61 vssrkqqnvd qavatlqgeg lsvtgtvchv gkaedrerlv atavklhggi dilvsnaavn
      121 pffgsimdvt eevwdkviyl fl
//
LOCUS       XP_006720071             706 aa            linear   PRI 05-AUG-2025
DEFINITION  fermitin family homolog 2 isoform X1 [Homo sapiens].
ACCESSION   XP_006720071
VERSION     XP_006720071.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720008.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..706
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..706
                     /product="fermitin family homolog 2 isoform X1"
                     /calculated_mol_wt=80644
     Region          17..96
                     /region_name="FERM_F0_KIND2"
                     /note="FERM (Four.1 protein, Ezrin, Radixin, Moesin)
                     domain, F0 sub-domain, found in kindlin-2 (KIND2);
                     cd17181"
                     /db_xref="CDD:340701"
     Region          97..288
                     /region_name="FERM_F1_KIND2"
                     /note="FERM (Four.1 protein, Ezrin, Radixin, Moesin)
                     domain, F1 sub-domain, found in kindlin-2 (KIND2);
                     cd17184"
                     /db_xref="CDD:340704"
     Region          <252..>335
                     /region_name="B41"
                     /note="Band 4.1 homologues; smart00295"
                     /db_xref="CDD:214604"
     Region          384..508
                     /region_name="PH_fermitin"
                     /note="Fermitin family pleckstrin homology (PH) domain;
                     cd01237"
                     /db_xref="CDD:269943"
     Site            order(392,394,396,400..402,404,417,419,430)
                     /site_type="other"
                     /note="phosphoinositide binding site [chemical binding]"
                     /db_xref="CDD:269943"
     Region          <466..599
                     /region_name="FERM_M"
                     /note="FERM central domain; pfam00373"
                     /db_xref="CDD:459788"
     Region          593..684
                     /region_name="FERM_C_fermitin"
                     /note="FERM domain C-lobe of the Fermitin family; cd13205"
                     /db_xref="CDD:270026"
     Site            order(603,621,623,631)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:270026"
     Site            order(635,640..643,673,677,680..681)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270026"
     Site            673..684
                     /site_type="other"
                     /note="putative actin binding site 2 [polypeptide
                     binding]"
                     /db_xref="CDD:270026"
     CDS             1..706
                     /gene="FERMT2"
                     /gene_synonym="KIND2; mig-2; MIG2; PLEKHC1; UNC112;
                     UNC112B"
                     /coded_by="XM_006720008.4:140..2260"
                     /db_xref="GeneID:10979"
                     /db_xref="HGNC:HGNC:15767"
                     /db_xref="MIM:607746"
ORIGIN      
        1 maldgirmpd gcyadgtwel svhvtdlnrd vtlrvtgevh iggvmlklve kldvkkdwsd
       61 halwwekkrt wllkthwtld kygiqadakl qftpqhkllr lqlpnmkyvk vkvnfsdrvf
      121 kavsdicktf nirhpeelsl lkkprdptkk kkkklddqse dealelegpl itpgsgtdvl
      181 yigplkgsiy sspglysktm tptydahdgs plsptsawfg dsalsegnpg ilavsqpits
      241 peilakmfkp qalldkakin qgwldssrsl meqdvkenea lllrfkyysf fdlnpkydai
      301 rinqlyeqak wailleeiec teeemmmfaa lqyhinklsi mtsenhlnns dkevdevdaa
      361 lsdleitleg gktstilgdi tsipeladyi kvfkpkkltl kgykqywctf kdtsiscyks
      421 keessgtpah qmnlrgcevt pdvnisgqkf nikllipvae gmneiwlrcd nekqyahwma
      481 acrlaskgkt madssynlev qnilsflkmq hlnpdpqlip eqittditpe clvsprylkk
      541 yknkqekgck khmpgyirdl itarileahq nvaqmsliea kmrfiqawqs lpefgithfi
      601 arfqggkkee ligiaynrli rmdastgdai ktwrfsnmkq wnvnweikmv tvefadevrl
      661 sfictevdck vvhefiggyi flstrakdqn esldeemfyk ltsgwv
//
LOCUS       XP_006720072             698 aa            linear   PRI 05-AUG-2025
DEFINITION  fermitin family homolog 2 isoform X2 [Homo sapiens].
ACCESSION   XP_006720072
VERSION     XP_006720072.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720009.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..698
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..698
                     /product="fermitin family homolog 2 isoform X2"
                     /calculated_mol_wt=79702
     Region          17..96
                     /region_name="FERM_F0_KIND2"
                     /note="FERM (Four.1 protein, Ezrin, Radixin, Moesin)
                     domain, F0 sub-domain, found in kindlin-2 (KIND2);
                     cd17181"
                     /db_xref="CDD:340701"
     Region          97..288
                     /region_name="FERM_F1_KIND2"
                     /note="FERM (Four.1 protein, Ezrin, Radixin, Moesin)
                     domain, F1 sub-domain, found in kindlin-2 (KIND2);
                     cd17184"
                     /db_xref="CDD:340704"
     Region          <252..>335
                     /region_name="B41"
                     /note="Band 4.1 homologues; smart00295"
                     /db_xref="CDD:214604"
     Region          384..508
                     /region_name="PH_fermitin"
                     /note="Fermitin family pleckstrin homology (PH) domain;
                     cd01237"
                     /db_xref="CDD:269943"
     Site            order(392,394,396,400..402,404,417,419,430)
                     /site_type="other"
                     /note="phosphoinositide binding site [chemical binding]"
                     /db_xref="CDD:269943"
     Region          <466..591
                     /region_name="FERM_M"
                     /note="FERM central domain; pfam00373"
                     /db_xref="CDD:459788"
     Region          585..676
                     /region_name="FERM_C_fermitin"
                     /note="FERM domain C-lobe of the Fermitin family; cd13205"
                     /db_xref="CDD:270026"
     Site            order(595,613,615,623)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:270026"
     Site            order(627,632..635,665,669,672..673)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270026"
     Site            665..676
                     /site_type="other"
                     /note="putative actin binding site 2 [polypeptide
                     binding]"
                     /db_xref="CDD:270026"
     CDS             1..698
                     /gene="FERMT2"
                     /gene_synonym="KIND2; mig-2; MIG2; PLEKHC1; UNC112;
                     UNC112B"
                     /coded_by="XM_006720009.4:140..2236"
                     /db_xref="GeneID:10979"
                     /db_xref="HGNC:HGNC:15767"
                     /db_xref="MIM:607746"
ORIGIN      
        1 maldgirmpd gcyadgtwel svhvtdlnrd vtlrvtgevh iggvmlklve kldvkkdwsd
       61 halwwekkrt wllkthwtld kygiqadakl qftpqhkllr lqlpnmkyvk vkvnfsdrvf
      121 kavsdicktf nirhpeelsl lkkprdptkk kkkklddqse dealelegpl itpgsgtdvl
      181 yigplkgsiy sspglysktm tptydahdgs plsptsawfg dsalsegnpg ilavsqpits
      241 peilakmfkp qalldkakin qgwldssrsl meqdvkenea lllrfkyysf fdlnpkydai
      301 rinqlyeqak wailleeiec teeemmmfaa lqyhinklsi mtsenhlnns dkevdevdaa
      361 lsdleitleg gktstilgdi tsipeladyi kvfkpkkltl kgykqywctf kdtsiscyks
      421 keessgtpah qmnlrgcevt pdvnisgqkf nikllipvae gmneiwlrcd nekqyahwma
      481 acrlaskgkt madssynlev qnilsflkmq hlnpdpqlip eqittditpe clvsprylkk
      541 yknkqpgyir dlitarilea hqnvaqmsli eakmrfiqaw qslpefgith fiarfqggkk
      601 eeligiaynr lirmdastgd aiktwrfsnm kqwnvnweik mvtvefadev rlsfictevd
      661 ckvvhefigg yiflstrakd qnesldeemf ykltsgwv
//
LOCUS       XP_006720073             695 aa            linear   PRI 05-AUG-2025
DEFINITION  fermitin family homolog 2 isoform X3 [Homo sapiens].
ACCESSION   XP_006720073
VERSION     XP_006720073.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720010.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..695
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..695
                     /product="fermitin family homolog 2 isoform X3"
                     /calculated_mol_wt=79487
     Region          17..96
                     /region_name="FERM_F0_KIND2"
                     /note="FERM (Four.1 protein, Ezrin, Radixin, Moesin)
                     domain, F0 sub-domain, found in kindlin-2 (KIND2);
                     cd17181"
                     /db_xref="CDD:340701"
     Region          97..277
                     /region_name="FERM_F1_KIND2"
                     /note="FERM (Four.1 protein, Ezrin, Radixin, Moesin)
                     domain, F1 sub-domain, found in kindlin-2 (KIND2);
                     cd17184"
                     /db_xref="CDD:340704"
     Region          <241..>324
                     /region_name="B41"
                     /note="Band 4.1 homologues; smart00295"
                     /db_xref="CDD:214604"
     Region          373..497
                     /region_name="PH_fermitin"
                     /note="Fermitin family pleckstrin homology (PH) domain;
                     cd01237"
                     /db_xref="CDD:269943"
     Site            order(381,383,385,389..391,393,406,408,419)
                     /site_type="other"
                     /note="phosphoinositide binding site [chemical binding]"
                     /db_xref="CDD:269943"
     Region          <455..588
                     /region_name="FERM_M"
                     /note="FERM central domain; pfam00373"
                     /db_xref="CDD:459788"
     Region          582..673
                     /region_name="FERM_C_fermitin"
                     /note="FERM domain C-lobe of the Fermitin family; cd13205"
                     /db_xref="CDD:270026"
     Site            order(592,610,612,620)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:270026"
     Site            order(624,629..632,662,666,669..670)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270026"
     Site            662..673
                     /site_type="other"
                     /note="putative actin binding site 2 [polypeptide
                     binding]"
                     /db_xref="CDD:270026"
     CDS             1..695
                     /gene="FERMT2"
                     /gene_synonym="KIND2; mig-2; MIG2; PLEKHC1; UNC112;
                     UNC112B"
                     /coded_by="XM_006720010.4:140..2227"
                     /db_xref="GeneID:10979"
                     /db_xref="HGNC:HGNC:15767"
                     /db_xref="MIM:607746"
ORIGIN      
        1 maldgirmpd gcyadgtwel svhvtdlnrd vtlrvtgevh iggvmlklve kldvkkdwsd
       61 halwwekkrt wllkthwtld kygiqadakl qftpqhkllr lqlpnmkyvk vkvnfsdrvf
      121 kavsdicktf nirhpeelsl lkkprdptkk kkkklddqse dealelegpl itpgsgsiys
      181 spglysktmt ptydahdgsp lsptsawfgd salsegnpgi lavsqpitsp eilakmfkpq
      241 alldkakinq gwldssrslm eqdvkeneal llrfkyysff dlnpkydair inqlyeqakw
      301 ailleeiect eeemmmfaal qyhinklsim tsenhlnnsd kevdevdaal sdleitlegg
      361 ktstilgdit sipeladyik vfkpkkltlk gykqywctfk dtsiscyksk eessgtpahq
      421 mnlrgcevtp dvnisgqkfn ikllipvaeg mneiwlrcdn ekqyahwmaa crlaskgktm
      481 adssynlevq nilsflkmqh lnpdpqlipe qittditpec lvsprylkky knkqekgckk
      541 hmpgyirdli tarileahqn vaqmslieak mrfiqawqsl pefgithfia rfqggkkeel
      601 igiaynrlir mdastgdaik twrfsnmkqw nvnweikmvt vefadevrls fictevdckv
      661 vhefiggyif lstrakdqne sldeemfykl tsgwv
//
LOCUS       XP_005267342             691 aa            linear   PRI 05-AUG-2025
DEFINITION  fermitin family homolog 2 isoform X4 [Homo sapiens].
ACCESSION   XP_005267342
VERSION     XP_005267342.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267285.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..691
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..691
                     /product="fermitin family homolog 2 isoform X4"
                     /calculated_mol_wt=78887
     Region          17..96
                     /region_name="FERM_F0_KIND2"
                     /note="FERM (Four.1 protein, Ezrin, Radixin, Moesin)
                     domain, F0 sub-domain, found in kindlin-2 (KIND2);
                     cd17181"
                     /db_xref="CDD:340701"
     Region          97..288
                     /region_name="FERM_F1_KIND2"
                     /note="FERM (Four.1 protein, Ezrin, Radixin, Moesin)
                     domain, F1 sub-domain, found in kindlin-2 (KIND2);
                     cd17184"
                     /db_xref="CDD:340704"
     Region          <252..>335
                     /region_name="B41"
                     /note="Band 4.1 homologues; smart00295"
                     /db_xref="CDD:214604"
     Region          384..508
                     /region_name="PH_fermitin"
                     /note="Fermitin family pleckstrin homology (PH) domain;
                     cd01237"
                     /db_xref="CDD:269943"
     Site            order(392,394,396,400..402,404,417,419,430)
                     /site_type="other"
                     /note="phosphoinositide binding site [chemical binding]"
                     /db_xref="CDD:269943"
     Region          <466..584
                     /region_name="FERM_M"
                     /note="FERM central domain; pfam00373"
                     /db_xref="CDD:459788"
     Region          578..669
                     /region_name="FERM_C_fermitin"
                     /note="FERM domain C-lobe of the Fermitin family; cd13205"
                     /db_xref="CDD:270026"
     Site            order(588,606,608,616)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:270026"
     Site            order(620,625..628,658,662,665..666)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270026"
     Site            658..669
                     /site_type="other"
                     /note="putative actin binding site 2 [polypeptide
                     binding]"
                     /db_xref="CDD:270026"
     CDS             1..691
                     /gene="FERMT2"
                     /gene_synonym="KIND2; mig-2; MIG2; PLEKHC1; UNC112;
                     UNC112B"
                     /coded_by="XM_005267285.4:140..2215"
                     /db_xref="GeneID:10979"
                     /db_xref="HGNC:HGNC:15767"
                     /db_xref="MIM:607746"
ORIGIN      
        1 maldgirmpd gcyadgtwel svhvtdlnrd vtlrvtgevh iggvmlklve kldvkkdwsd
       61 halwwekkrt wllkthwtld kygiqadakl qftpqhkllr lqlpnmkyvk vkvnfsdrvf
      121 kavsdicktf nirhpeelsl lkkprdptkk kkkklddqse dealelegpl itpgsgtdvl
      181 yigplkgsiy sspglysktm tptydahdgs plsptsawfg dsalsegnpg ilavsqpits
      241 peilakmfkp qalldkakin qgwldssrsl meqdvkenea lllrfkyysf fdlnpkydai
      301 rinqlyeqak wailleeiec teeemmmfaa lqyhinklsi mtsenhlnns dkevdevdaa
      361 lsdleitleg gktstilgdi tsipeladyi kvfkpkkltl kgykqywctf kdtsiscyks
      421 keessgtpah qmnlrgcevt pdvnisgqkf nikllipvae gmneiwlrcd nekqyahwma
      481 acrlaskgkt madssynlev qnilsflkmq hlnpdpqlip eqittditpe clvsprylkk
      541 yknkqitari leahqnvaqm slieakmrfi qawqslpefg ithfiarfqg gkkeeligia
      601 ynrlirmdas tgdaiktwrf snmkqwnvnw eikmvtvefa devrlsfict evdckvvhef
      661 iggyiflstr akdqneslde emfykltsgw v
//
LOCUS       XP_005267344            1174 aa            linear   PRI 05-AUG-2025
DEFINITION  tyrosine-protein phosphatase non-receptor type 21 isoform X1 [Homo
            sapiens].
ACCESSION   XP_005267344
VERSION     XP_005267344.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267287.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1174
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1174
                     /product="tyrosine-protein phosphatase non-receptor type
                     21 isoform X1"
                     /calculated_mol_wt=133151
     Region          20..106
                     /region_name="FERM_F1_PTPN21"
                     /note="FERM (Four.1 protein, Ezrin, Radixin, Moesin)
                     domain, F1 sub-domain, found in tyrosine-protein
                     phosphatase non-receptor type 21 (PTPN21) and similar
                     proteins; cd17192"
                     /db_xref="CDD:340712"
     Region          24..222
                     /region_name="B41"
                     /note="Band 4.1 homologues; smart00295"
                     /db_xref="CDD:214604"
     Region          217..307
                     /region_name="FERM_C_PTPN14_PTPN21"
                     /note="FERM domain C-lobe of Protein tyrosine phosphatase
                     non-receptor proteins 14 and 21 (PTPN14 and 21); cd13188"
                     /db_xref="CDD:270009"
     Site            order(226,243,245,252)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:270009"
     Site            order(256,261..264,294,298,301..302)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270009"
     Site            294..305
                     /site_type="other"
                     /note="putative actin binding site 2 [polypeptide
                     binding]"
                     /db_xref="CDD:270009"
     Region          883..1169
                     /region_name="PTP_DSP_cys"
                     /note="cys-based protein tyrosine phosphatase and
                     dual-specificity phosphatase superfamily; cl28904"
                     /db_xref="CDD:475123"
     CDS             1..1174
                     /gene="PTPN21"
                     /gene_synonym="PTPD1; PTPRL10"
                     /coded_by="XM_005267287.4:444..3968"
                     /db_xref="GeneID:11099"
                     /db_xref="HGNC:HGNC:9651"
                     /db_xref="MIM:603271"
ORIGIN      
        1 mplpfglklk rtrrytvssk sclvariqll nnefveftls vestgqesle avaqrlelre
       61 vtyfslwyyn kqnqrrwvdl ekplkkqldk yaleptvyfg vvfyvpsvsq lqqeitryqy
      121 ylqlkkdile gsipctleqa iqlaglavqa dfgdfdqyes qdflqkfalf pvgwlqdekv
      181 leeatqkval lhqkyrglta pdaemlymqe vermdgygee sypakdsqgs disigacleg
      241 ifvkhkngrh pvvfrwhdia nmshnksffa lelankeeti qfqtedmeta kyiwrlcvar
      301 hkfyrlnqcn lqtqtvtvnp irrrsssrms lpkpqpyvmp pppqlhyngh ytepyassqd
      361 nlfvpnqngy ychsqtsldr aqidlngrir ngsvysahst nslnnpqpyl qpspmssnps
      421 itgsdvmrpd ylpshrhsav ippsyrptpd yetvmkqlnr glvhaerqsh slrnlnigss
      481 yaysrpaalv ysqpeireha qlpspaaahc pfslsysfhs pspypypaer rpvvgavsvp
      541 eltnaqlqaq dypspnimrt qvyrppppyp pprpanstpd lsrhlyisss npdlitrrvh
      601 hsvqtfqeds lpvahslqev sepltaarha qlhkrnsiev aglshglegl rlkertlsas
      661 aaevapravs vgsqpsvfte rtqregpeea eglryghkks lsdatmlihs seeeededfe
      721 eesgarappa rareprpgla qdppgcprvl lagplhilep kahvpdaekr mmdsspvrtt
      781 aeaqrpwrdg llmpsmsesd lttsgryrar rdslkkrpvs dllsgkkniv eglpplggmk
      841 ktrvdakkig plklaalngl slsrvplpde gkevatratn derckileqr leqgmvftey
      901 erilkkrlvd gecstarlpe naernrfqdv lpyddvrvel vptkenntgy inashikvsv
      961 sgiewdyiat qgplqntcqd fwqmvweqgi aiiamvtaee eggreksfry wprlgsrhnt
     1021 vtygrfkitt rfrtdsgcya ttglkmkhll tgqertvwhl qytdwpehgc pedlkgflsy
     1081 leeiqsvrrh tnstsdpqsp nppllvhcsa gvgrtgvvil seimiacleh nevldiprvl
     1141 dmlrqqrmml vqtlcqytfv yrvliqflks srli
//
LOCUS       XP_011534669            1174 aa            linear   PRI 05-AUG-2025
DEFINITION  tyrosine-protein phosphatase non-receptor type 21 isoform X1 [Homo
            sapiens].
ACCESSION   XP_011534669
VERSION     XP_011534669.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536367.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1174
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1174
                     /product="tyrosine-protein phosphatase non-receptor type
                     21 isoform X1"
                     /calculated_mol_wt=133151
     Region          20..106
                     /region_name="FERM_F1_PTPN21"
                     /note="FERM (Four.1 protein, Ezrin, Radixin, Moesin)
                     domain, F1 sub-domain, found in tyrosine-protein
                     phosphatase non-receptor type 21 (PTPN21) and similar
                     proteins; cd17192"
                     /db_xref="CDD:340712"
     Region          24..222
                     /region_name="B41"
                     /note="Band 4.1 homologues; smart00295"
                     /db_xref="CDD:214604"
     Region          217..307
                     /region_name="FERM_C_PTPN14_PTPN21"
                     /note="FERM domain C-lobe of Protein tyrosine phosphatase
                     non-receptor proteins 14 and 21 (PTPN14 and 21); cd13188"
                     /db_xref="CDD:270009"
     Site            order(226,243,245,252)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:270009"
     Site            order(256,261..264,294,298,301..302)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270009"
     Site            294..305
                     /site_type="other"
                     /note="putative actin binding site 2 [polypeptide
                     binding]"
                     /db_xref="CDD:270009"
     Region          883..1169
                     /region_name="PTP_DSP_cys"
                     /note="cys-based protein tyrosine phosphatase and
                     dual-specificity phosphatase superfamily; cl28904"
                     /db_xref="CDD:475123"
     CDS             1..1174
                     /gene="PTPN21"
                     /gene_synonym="PTPD1; PTPRL10"
                     /coded_by="XM_011536367.4:520..4044"
                     /db_xref="GeneID:11099"
                     /db_xref="HGNC:HGNC:9651"
                     /db_xref="MIM:603271"
ORIGIN      
        1 mplpfglklk rtrrytvssk sclvariqll nnefveftls vestgqesle avaqrlelre
       61 vtyfslwyyn kqnqrrwvdl ekplkkqldk yaleptvyfg vvfyvpsvsq lqqeitryqy
      121 ylqlkkdile gsipctleqa iqlaglavqa dfgdfdqyes qdflqkfalf pvgwlqdekv
      181 leeatqkval lhqkyrglta pdaemlymqe vermdgygee sypakdsqgs disigacleg
      241 ifvkhkngrh pvvfrwhdia nmshnksffa lelankeeti qfqtedmeta kyiwrlcvar
      301 hkfyrlnqcn lqtqtvtvnp irrrsssrms lpkpqpyvmp pppqlhyngh ytepyassqd
      361 nlfvpnqngy ychsqtsldr aqidlngrir ngsvysahst nslnnpqpyl qpspmssnps
      421 itgsdvmrpd ylpshrhsav ippsyrptpd yetvmkqlnr glvhaerqsh slrnlnigss
      481 yaysrpaalv ysqpeireha qlpspaaahc pfslsysfhs pspypypaer rpvvgavsvp
      541 eltnaqlqaq dypspnimrt qvyrppppyp pprpanstpd lsrhlyisss npdlitrrvh
      601 hsvqtfqeds lpvahslqev sepltaarha qlhkrnsiev aglshglegl rlkertlsas
      661 aaevapravs vgsqpsvfte rtqregpeea eglryghkks lsdatmlihs seeeededfe
      721 eesgarappa rareprpgla qdppgcprvl lagplhilep kahvpdaekr mmdsspvrtt
      781 aeaqrpwrdg llmpsmsesd lttsgryrar rdslkkrpvs dllsgkkniv eglpplggmk
      841 ktrvdakkig plklaalngl slsrvplpde gkevatratn derckileqr leqgmvftey
      901 erilkkrlvd gecstarlpe naernrfqdv lpyddvrvel vptkenntgy inashikvsv
      961 sgiewdyiat qgplqntcqd fwqmvweqgi aiiamvtaee eggreksfry wprlgsrhnt
     1021 vtygrfkitt rfrtdsgcya ttglkmkhll tgqertvwhl qytdwpehgc pedlkgflsy
     1081 leeiqsvrrh tnstsdpqsp nppllvhcsa gvgrtgvvil seimiacleh nevldiprvl
     1141 dmlrqqrmml vqtlcqytfv yrvliqflks srli
//
LOCUS       XP_011534670            1051 aa            linear   PRI 05-AUG-2025
DEFINITION  tyrosine-protein phosphatase non-receptor type 21 isoform X2 [Homo
            sapiens].
ACCESSION   XP_011534670
VERSION     XP_011534670.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536368.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1051
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1051
                     /product="tyrosine-protein phosphatase non-receptor type
                     21 isoform X2"
                     /calculated_mol_wt=118898
     Region          <27..99
                     /region_name="B41"
                     /note="Band 4.1 homologues; smart00295"
                     /db_xref="CDD:214604"
     Region          94..184
                     /region_name="FERM_C_PTPN14_PTPN21"
                     /note="FERM domain C-lobe of Protein tyrosine phosphatase
                     non-receptor proteins 14 and 21 (PTPN14 and 21); cd13188"
                     /db_xref="CDD:270009"
     Site            order(103,120,122,129)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:270009"
     Site            order(133,138..141,171,175,178..179)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270009"
     Site            171..182
                     /site_type="other"
                     /note="putative actin binding site 2 [polypeptide
                     binding]"
                     /db_xref="CDD:270009"
     Region          760..1046
                     /region_name="PTP_DSP_cys"
                     /note="cys-based protein tyrosine phosphatase and
                     dual-specificity phosphatase superfamily; cl28904"
                     /db_xref="CDD:475123"
     CDS             1..1051
                     /gene="PTPN21"
                     /gene_synonym="PTPD1; PTPRL10"
                     /coded_by="XM_011536368.3:111..3266"
                     /db_xref="GeneID:11099"
                     /db_xref="HGNC:HGNC:9651"
                     /db_xref="MIM:603271"
ORIGIN      
        1 mhwnlpsile wcfmclqfls csrrlpadfg dfdqyesqdf lqkfalfpvg wlqdekvlee
       61 atqkvallhq kyrgltapda emlymqever mdgygeesyp akdsqgsdis igaclegifv
      121 khkngrhpvv frwhdianms hnksffalel ankeetiqfq tedmetakyi wrlcvarhkf
      181 yrlnqcnlqt qtvtvnpirr rsssrmslpk pqpyvmpppp qlhynghyte pyassqdnlf
      241 vpnqngyych sqtsldraqi dlngrirngs vysahstnsl nnpqpylqps pmssnpsitg
      301 sdvmrpdylp shrhsavipp syrptpdyet vmkqlnrglv haerqshslr nlnigssyay
      361 srpaalvysq peirehaqlp spaaahcpfs lsysfhspsp ypypaerrpv vgavsvpelt
      421 naqlqaqdyp spnimrtqvy rppppypppr panstpdlsr hlyisssnpd litrrvhhsv
      481 qtfqedslpv ahslqevsep ltaarhaqlh krnsievagl shgleglrlk ertlsasaae
      541 vapravsvgs qpsvftertq regpeeaegl ryghkkslsd atmlihssee eededfeees
      601 garapparar eprpglaqdp pgcprvllag plhilepkah vpdaekrmmd sspvrttaea
      661 qrpwrdgllm psmsesdltt sgryrarrds lkkrpvsdll sgkknivegl pplggmkktr
      721 vdakkigplk laalnglsls rvplpdegke vatratnder ckileqrleq gmvfteyeri
      781 lkkrlvdgec starlpenae rnrfqdvlpy ddvrvelvpt kenntgyina shikvsvsgi
      841 ewdyiatqgp lqntcqdfwq mvweqgiaii amvtaeeegg reksfrywpr lgsrhntvty
      901 grfkittrfr tdsgcyattg lkmkhlltgq ertvwhlqyt dwpehgcped lkgflsylee
      961 iqsvrrhtns tsdpqspnpp llvhcsagvg rtgvvilsei miaclehnev ldiprvldml
     1021 rqqrmmlvqt lcqytfvyrv liqflkssrl i
//
LOCUS       XP_016876428             970 aa            linear   PRI 05-AUG-2025
DEFINITION  tyrosine-protein phosphatase non-receptor type 21 isoform X3 [Homo
            sapiens].
ACCESSION   XP_016876428
VERSION     XP_016876428.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020939.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..970
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..970
                     /product="tyrosine-protein phosphatase non-receptor type
                     21 isoform X3"
                     /calculated_mol_wt=109374
     Region          13..103
                     /region_name="FERM_C_PTPN14_PTPN21"
                     /note="FERM domain C-lobe of Protein tyrosine phosphatase
                     non-receptor proteins 14 and 21 (PTPN14 and 21); cd13188"
                     /db_xref="CDD:270009"
     Site            order(22,39,41,48)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:270009"
     Site            order(52,57..60,90,94,97..98)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270009"
     Site            90..101
                     /site_type="other"
                     /note="putative actin binding site 2 [polypeptide
                     binding]"
                     /db_xref="CDD:270009"
     Region          679..965
                     /region_name="PTP_DSP_cys"
                     /note="cys-based protein tyrosine phosphatase and
                     dual-specificity phosphatase superfamily; cl28904"
                     /db_xref="CDD:475123"
     CDS             1..970
                     /gene="PTPN21"
                     /gene_synonym="PTPD1; PTPRL10"
                     /coded_by="XM_017020939.2:484..3396"
                     /db_xref="GeneID:11099"
                     /db_xref="HGNC:HGNC:9651"
                     /db_xref="MIM:603271"
ORIGIN      
        1 mlymqeverm dgygeesypa kdsqgsdisi gaclegifvk hkngrhpvvf rwhdianmsh
       61 nksffalela nkeetiqfqt edmetakyiw rlcvarhkfy rlnqcnlqtq tvtvnpirrr
      121 sssrmslpkp qpyvmppppq lhynghytep yassqdnlfv pnqngyychs qtsldraqid
      181 lngrirngsv ysahstnsln npqpylqpsp mssnpsitgs dvmrpdylps hrhsavipps
      241 yrptpdyetv mkqlnrglvh aerqshslrn lnigssyays rpaalvysqp eirehaqlps
      301 paaahcpfsl sysfhspspy pypaerrpvv gavsvpeltn aqlqaqdyps pnimrtqvyr
      361 ppppyppprp anstpdlsrh lyisssnpdl itrrvhhsvq tfqedslpva hslqevsepl
      421 taarhaqlhk rnsievagls hgleglrlke rtlsasaaev apravsvgsq psvftertqr
      481 egpeeaeglr yghkkslsda tmlihsseee ededfeeesg arapparare prpglaqdpp
      541 gcprvllagp lhilepkahv pdaekrmmds spvrttaeaq rpwrdgllmp smsesdltts
      601 gryrarrdsl kkrpvsdlls gkkniveglp plggmkktrv dakkigplkl aalnglslsr
      661 vplpdegkev atratnderc kileqrleqg mvfteyeril kkrlvdgecs tarlpenaer
      721 nrfqdvlpyd dvrvelvptk enntgyinas hikvsvsgie wdyiatqgpl qntcqdfwqm
      781 vweqgiaiia mvtaeeeggr eksfrywprl gsrhntvtyg rfkittrfrt dsgcyattgl
      841 kmkhlltgqe rtvwhlqytd wpehgcpedl kgflsyleei qsvrrhtnst sdpqspnppl
      901 lvhcsagvgr tgvvilseim iaclehnevl diprvldmlr qqrmmlvqtl cqytfvyrvl
      961 iqflkssrli
//
LOCUS       XP_011534672             457 aa            linear   PRI 05-AUG-2025
DEFINITION  chromogranin-A isoform X1 [Homo sapiens].
ACCESSION   XP_011534672
VERSION     XP_011534672.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536370.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..457
                     /product="chromogranin-A isoform X1"
                     /calculated_mol_wt=50557
     Region          25..457
                     /region_name="Granin"
                     /note="Granin (chromogranin or secretogranin); pfam01271"
                     /db_xref="CDD:279595"
     CDS             1..457
                     /gene="CHGA"
                     /gene_synonym="CGA; PHE5; PHES"
                     /coded_by="XM_011536370.3:538..1911"
                     /db_xref="GeneID:1113"
                     /db_xref="HGNC:HGNC:1929"
                     /db_xref="MIM:118910"
ORIGIN      
        1 mrsaavlall lcagqvtalp vnspmnkgdt evmkcivevi sdtlskpspm pvsqecfetl
       61 rgderilsil rhqnllkelq dlalqgaker ahqqkkhsgf edelsevlen qssqaelkea
      121 veepsskdvm ekredskeae ksgeatdgar pqalpepmqe skaegnnqap geeeeeeeea
      181 tnthppaslp sqkypgpqae gdseglsqgl vdrekglsae pgwqakreee eeeeeeaeag
      241 eeavpeeegp tvvlnphpsl gykeirkges rsealavdga gkpgaeeaqd pegkgeqehs
      301 qqkeeeeema vvpqglfrgg ksgeleqeee rlskewedsk rwskmdqlak eltaekrleg
      361 qeeeednrds smklsfrara ygfrgpgpql rrgwrpssre dsleaglplq vrgypeekke
      421 eegsanrrpe dqeleslsai eaelekvahq lqalrrg
//
LOCUS       XP_011534673             159 aa            linear   PRI 05-AUG-2025
DEFINITION  AP-4 complex subunit sigma-1 isoform X1 [Homo sapiens].
ACCESSION   XP_011534673
VERSION     XP_011534673.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536371.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..159
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..159
                     /product="AP-4 complex subunit sigma-1 isoform X1"
                     /calculated_mol_wt=18433
     Region          3..>105
                     /region_name="longin-like"
                     /note="Longin-like domains; cl38905"
                     /db_xref="CDD:365781"
     CDS             1..159
                     /gene="AP4S1"
                     /gene_synonym="AP47B; CLA20; CLAPS4; CPSQ6; SPG52"
                     /coded_by="XM_011536371.4:247..726"
                     /db_xref="GeneID:11154"
                     /db_xref="HGNC:HGNC:575"
                     /db_xref="MIM:607243"
ORIGIN      
        1 mikfflmvnk qgqtrlskyy ehvdinkrtl letevikscl srsneqcsfi eykdfkliyr
       61 qyaalfivvg vndtenemai yefihnfvev ldeyfsrvse ldvsffntvf hstwqmhsgp
      121 yqepidelpk icsalepqqt cfspdsssfk gaasttpiy
//
LOCUS       XP_005267350             159 aa            linear   PRI 05-AUG-2025
DEFINITION  AP-4 complex subunit sigma-1 isoform X1 [Homo sapiens].
ACCESSION   XP_005267350
VERSION     XP_005267350.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267293.6
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..159
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..159
                     /product="AP-4 complex subunit sigma-1 isoform X1"
                     /calculated_mol_wt=18433
     Region          3..>105
                     /region_name="longin-like"
                     /note="Longin-like domains; cl38905"
                     /db_xref="CDD:365781"
     CDS             1..159
                     /gene="AP4S1"
                     /gene_synonym="AP47B; CLA20; CLAPS4; CPSQ6; SPG52"
                     /coded_by="XM_005267293.6:783..1262"
                     /db_xref="GeneID:11154"
                     /db_xref="HGNC:HGNC:575"
                     /db_xref="MIM:607243"
ORIGIN      
        1 mikfflmvnk qgqtrlskyy ehvdinkrtl letevikscl srsneqcsfi eykdfkliyr
       61 qyaalfivvg vndtenemai yefihnfvev ldeyfsrvse ldvsffntvf hstwqmhsgp
      121 yqepidelpk icsalepqqt cfspdsssfk gaasttpiy
//
LOCUS       XP_011534674             159 aa            linear   PRI 05-AUG-2025
DEFINITION  AP-4 complex subunit sigma-1 isoform X1 [Homo sapiens].
ACCESSION   XP_011534674
VERSION     XP_011534674.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536372.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..159
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..159
                     /product="AP-4 complex subunit sigma-1 isoform X1"
                     /calculated_mol_wt=18433
     Region          3..>105
                     /region_name="longin-like"
                     /note="Longin-like domains; cl38905"
                     /db_xref="CDD:365781"
     CDS             1..159
                     /gene="AP4S1"
                     /gene_synonym="AP47B; CLA20; CLAPS4; CPSQ6; SPG52"
                     /coded_by="XM_011536372.4:747..1226"
                     /db_xref="GeneID:11154"
                     /db_xref="HGNC:HGNC:575"
                     /db_xref="MIM:607243"
ORIGIN      
        1 mikfflmvnk qgqtrlskyy ehvdinkrtl letevikscl srsneqcsfi eykdfkliyr
       61 qyaalfivvg vndtenemai yefihnfvev ldeyfsrvse ldvsffntvf hstwqmhsgp
      121 yqepidelpk icsalepqqt cfspdsssfk gaasttpiy
//
LOCUS       XP_006720075            1127 aa            linear   PRI 05-AUG-2025
DEFINITION  WD repeat and HMG-box DNA-binding protein 1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_006720075
VERSION     XP_006720075.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720012.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1127
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1127
                     /product="WD repeat and HMG-box DNA-binding protein 1
                     isoform X1"
                     /calculated_mol_wt=125709
     Region          10..288
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cd00200"
                     /db_xref="CDD:238121"
     Site            order(12,30,34,40,42,54..55,69,73,79..80,92..93,110,115,
                     121..122,135,152,157,163..164,186,203,207,213,224..225,
                     246,251,257..258,270)
                     /site_type="active"
                     /note="structural tetrad [active]"
                     /db_xref="CDD:238121"
     Region          21..54
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          59..92
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          97..133
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          140..182
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          189..225
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          233..269
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          431..714
                     /region_name="Mcl1_mid"
                     /note="Minichromosome loss protein, Mcl1, middle region;
                     pfam12341"
                     /db_xref="CDD:463539"
     Region          1012..1074
                     /region_name="HMG-box_WDHD1"
                     /note="high mobility group (HMG)-box found in WD repeat
                     and HMG-box DNA-binding protein 1 (WDHD1) and similar
                     proteins; cd21993"
                     /db_xref="CDD:438809"
     Site            order(1014..1015,1017..1021,1024..1025,1032,1045..1046,
                     1049,1052..1053,1060,1064,1067,1071,1074)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:438809"
     CDS             1..1127
                     /gene="WDHD1"
                     /gene_synonym="AND-1; AND1; CHTF4; CTF4"
                     /coded_by="XM_006720012.2:89..3472"
                     /db_xref="GeneID:11169"
                     /db_xref="HGNC:HGNC:23170"
                     /db_xref="MIM:608126"
ORIGIN      
        1 mpatrkpmry ghteghtevc fddsgsfivt cgsdgdvriw edlddddpkf invgekaysc
       61 alksgklvta vsnntiqvht fpegvpdgil trfttnanhv vfngdgtkia agssdflvki
      121 vdvmdssqqk tfrghdapvl slsfdpkdif lasascdgsv rvwqisdqtc aiswpllqkc
      181 ndvinaksic rlawqpksgk llaipveksv klyrreswsh qfdlsdnfis qtlnivtwsp
      241 cgqylaagsi ngliivwnve tkdcmervkh ekgyaicgla whptcgrisy tdaegnlgll
      301 envcdpsgkt ssskvssrve kdyndlfdgd dmsnagdfln dnaveipsfs kgiinddedd
      361 edlmmasgrp rqrshiledd ensvdismlk tgssllkeee edgqegsihn lplvtsqrpf
      421 ydgpmptprq kpfqsgstpl hlthrfmvwn sigiircynd eqdnaidvef hdtsihhath
      481 lsntlnytia dlsheailla cestdelask lhclhfsswd sskewiidlp qnedieaicl
      541 gqgwaaaats alllrlftig gvqkevfsla gpvvsmaghg eqlfivyhrg tgfdgdqclg
      601 vqllelgkkk kqilhgdplp ltrksylawi gfsaegtpcy vdsegivrml nrglgntwtp
      661 icntrehckg ksdhywvvgi henpqqlrci pckgsrfppt lprpavails fklpycqiat
      721 ekgqmeeqfw rsvifhnhld ylakngyeye estknqatke qqellmkmla lscklerefr
      781 cveladlmtq navnlaikya srsrklilaq klselaveka aeltatqvee eeeeedfrkk
      841 lnagysntat ewsqprfrnq veedaedsge addeekpeih kpgqnsfsks tnssdvsaks
      901 vtfssqgrvn pfkvsasske pamsmnsars tnildnmgks skkstalsrt tnnekspiik
      961 plipkpkpkq asaasyfqkr nsqtnkteev keenlknvls etpaicppqn tenqrpktgf
     1021 qmwleenrsn ilsdnpdfsd eadiikegmi rfrvlsteer kvwankakge tasegteakk
     1081 rkrvvdesde tenqeekake nlnlskkqkp ldfstnqkls afafkqe
//
LOCUS       XP_011534675             766 aa            linear   PRI 05-AUG-2025
DEFINITION  WD repeat and HMG-box DNA-binding protein 1 isoform X2 [Homo
            sapiens].
ACCESSION   XP_011534675
VERSION     XP_011534675.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536373.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..766
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..766
                     /product="WD repeat and HMG-box DNA-binding protein 1
                     isoform X2"
                     /calculated_mol_wt=85982
     Region          68..351
                     /region_name="Mcl1_mid"
                     /note="Minichromosome loss protein, Mcl1, middle region;
                     pfam12341"
                     /db_xref="CDD:463539"
     Region          651..713
                     /region_name="HMG-box_WDHD1"
                     /note="high mobility group (HMG)-box found in WD repeat
                     and HMG-box DNA-binding protein 1 (WDHD1) and similar
                     proteins; cd21993"
                     /db_xref="CDD:438809"
     Site            order(653..654,656..660,663..664,671,684..685,688,
                     691..692,699,703,706,710,713)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:438809"
     CDS             1..766
                     /gene="WDHD1"
                     /gene_synonym="AND-1; AND1; CHTF4; CTF4"
                     /coded_by="XM_011536373.3:122..2422"
                     /db_xref="GeneID:11169"
                     /db_xref="HGNC:HGNC:23170"
                     /db_xref="MIM:608126"
ORIGIN      
        1 mmasgrprqr shileddens vdismlktgs sllkeeeedg qegsihnlpl vtsqrpfydg
       61 pmptprqkpf qsgstplhlt hrfmvwnsig iircyndeqd naidvefhdt sihhathlsn
      121 tlnytiadls heaillaces tdelasklhc lhfsswdssk ewiidlpqne dieaiclgqg
      181 waaaatsall lrlftiggvq kevfslagpv vsmaghgeql fivyhrgtgf dgdqclgvql
      241 lelgkkkkqi lhgdplpltr ksylawigfs aegtpcyvds egivrmlnrg lgntwtpicn
      301 trehckgksd hywvvgihen pqqlrcipck gsrfpptlpr pavailsfkl pycqiatekg
      361 qmeeqfwrsv ifhnhldyla kngyeyeest knqatkeqqe llmkmlalsc klerefrcve
      421 ladlmtqnav nlaikyasrs rklilaqkls elavekaael tatqveeeee eedfrkklna
      481 gysntatews qprfrnqvee daedsgeadd eekpeihkpg qnsfskstns sdvsaksgav
      541 tfssqgrvnp fkvsasskep amsmnsarst nildnmgkss kkstalsrtt nnekspiikp
      601 lipkpkpkqa saasyfqkrn sqtnkteevk eenlknvlse tpaicppqnt enqrpktgfq
      661 mwleenrsni lsdnpdfsde adiikegmir frvlsteerk vwankakget asegteakkr
      721 krvvdesdet enqeekaken lnlskkqkpl dfstnqklsa fafkqe
//
LOCUS       XP_024305228            1556 aa            linear   PRI 05-AUG-2025
DEFINITION  bromodomain adjacent to zinc finger domain protein 1A isoform X1
            [Homo sapiens].
ACCESSION   XP_024305228
VERSION     XP_024305228.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449460.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1556
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1556
                     /product="bromodomain adjacent to zinc finger domain
                     protein 1A isoform X1"
                     /calculated_mol_wt=178572
     Region          23..122
                     /region_name="WAC_Acf1_DNA_bd"
                     /note="ATP-utilizing chromatin assembly and remodelling
                     N-terminal; pfam10537"
                     /db_xref="CDD:463140"
     Region          422..485
                     /region_name="DDT"
                     /note="domain in different transcription and chromosome
                     remodeling factors; smart00571"
                     /db_xref="CDD:214726"
     Region          590..635
                     /region_name="WHIM1"
                     /note="WSTF, HB1, Itc1p, MBD9 motif 1; pfam15612"
                     /db_xref="CDD:464774"
     Region          <645..788
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          800..926
                     /region_name="WSD"
                     /note="Williams-Beuren syndrome DDT (WSD), D-TOX E motif;
                     pfam15613"
                     /db_xref="CDD:464775"
     Region          1150..1195
                     /region_name="PHD_BAZ1A"
                     /note="PHD finger found in bromodomain adjacent to zinc
                     finger domain protein 1A (BAZ1A); cd15627"
                     /db_xref="CDD:277097"
     Site            order(1150,1162..1166,1170,1190)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277097"
     Region          1423..1535
                     /region_name="Bromo_Acf1_like"
                     /note="Bromodomain; Acf1_like or BAZ1A_like subfamily.
                     Bromo adjacent to zinc finger 1A (BAZ1A) was identified as
                     a novel human bromodomain gene by cDNA library screening.
                     The Drosophila homologue, Acf1, is part of the CHRAC
                     (chromatin accessibility complex)...; cd05504"
                     /db_xref="CDD:99936"
     Site            order(1458,1463,1466,1505,1509,1515)
                     /site_type="other"
                     /note="putative acetyllysine binding site [chemical
                     binding]"
                     /db_xref="CDD:99936"
     CDS             1..1556
                     /gene="BAZ1A"
                     /gene_synonym="ACF1; hACF1; WALp1; WCRF180"
                     /coded_by="XM_024449460.2:551..5221"
                     /db_xref="GeneID:11177"
                     /db_xref="HGNC:HGNC:960"
                     /db_xref="MIM:605680"
ORIGIN      
        1 mpllhrkpfv rqkppadlrp deevfyckvt neifrhyddf fertilcnsl vwscavtgrp
       61 gltyqeales ekkarqnlqs fpepliipvl yltslthrsr lheicddifa yvkdryfvee
      121 tvevirnnga rlqcrilevl ppshqngfan ghvnsvdget iiisdsddse tqscsfqngk
      181 kkdaidpllf kykvqptkke lhesaivkat qisrrkhlfs rdklklflkq hcepqdgvik
      241 ikasslstyk iaeqdfsyff pddpptfifs panrrrgrpp krihisqedn vankqtlasy
      301 rskatkerdk llkqeemksl afekaklkre kadaleakkk ekedkekkre elkkiveeer
      361 lkkkeekerl kverekerek lreekrkyve ylkqwskpre dmecddlkel peptpvktrl
      421 ppeifgdalm vleflnafge lfdlqdefpd gvtlevleea lvgndsegpl cellffflta
      481 ifqaiaeeee evakeqltda dtkdlteald edadptksal savaslaaaw pqlhqgcslk
      541 sldldsctls eilrlhilas gadvtsanak yryqkrggfd atddacmelr lsnpslvkkl
      601 sstsvydltp gekmkilhal cgklltlvst rdfiedyvdi lrqakqefre lkaeqhrker
      661 eeaaarirkr keeklkeqeq kmkekqeklk edeqrnstad isigeeered fdtsieskdt
      721 eqkeldqdmv tededdpgsh krgrrgkrgq ngfkeftrqe qincvtrepl tadeeealkq
      781 ehqrkekell ekiqsaiact nifplgrdrm yrrywifpsi pglfieedys gltedmllpr
      841 pssfqnnvqs qdpqvstktg eplmsestsn idqgprdhsv qlpkpvhkpn rwcfyssceq
      901 ldqliealns rghresalke tllqeksric aqlarfseek fhfsdkpqpd skptysrgrs
      961 snaydpsqmc aekqlelrlr dflldiedri yqgtlgaikv tdrhiwrsal esgryellse
     1021 enkengiikt vnedveemei deqtkvivkd rllgiktetp stvstnastp qsvssvvhyl
     1081 amalfqieqg ierrflkapl dasdsgrsyk tvldrwresl lssaslsqvf lhlstldrsv
     1141 iwsksilnar ckicrkkgda enmvlcdgcd rghhtycvrp klktvpegdw fcpecrpkqr
     1201 srrlssrqrp slesdedved smggeddevd gdeeegqsee eeyeveqded dsqeeeevsl
     1261 pkrgrpqvrl pvktrgklss sfssrgqqqe pgrypsrsqq stpkttvssk tgrslrkins
     1321 apptetkslr iasrstrhsh gplqadvfve llsprrkrrg rksanntpen spnfpnfrvi
     1381 atksseqsrs vniasklslq eseskrrcrk rqspepspvt lgrrssgrqg gvhelsafeq
     1441 lvvelvrhdd swpflklvsk iqvpdyydii kkpialniir ekvnkceykl asefiddiel
     1501 mfsncfeynp rntseakagt rlqaffhiqa qklglhvtps nvdqvstppa akksri
//
LOCUS       XP_047286843            1524 aa            linear   PRI 05-AUG-2025
DEFINITION  bromodomain adjacent to zinc finger domain protein 1A isoform X2
            [Homo sapiens].
ACCESSION   XP_047286843
VERSION     XP_047286843.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430887.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1524
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1524
                     /product="bromodomain adjacent to zinc finger domain
                     protein 1A isoform X2"
                     /calculated_mol_wt=175254
     Region          23..122
                     /region_name="WAC_Acf1_DNA_bd"
                     /note="ATP-utilizing chromatin assembly and remodelling
                     N-terminal; pfam10537"
                     /db_xref="CDD:463140"
     Region          422..485
                     /region_name="DDT"
                     /note="domain in different transcription and chromosome
                     remodeling factors; smart00571"
                     /db_xref="CDD:214726"
     Region          558..603
                     /region_name="WHIM1"
                     /note="WSTF, HB1, Itc1p, MBD9 motif 1; pfam15612"
                     /db_xref="CDD:464774"
     Region          <613..756
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          768..894
                     /region_name="WSD"
                     /note="Williams-Beuren syndrome DDT (WSD), D-TOX E motif;
                     pfam15613"
                     /db_xref="CDD:464775"
     Region          1118..1163
                     /region_name="PHD_BAZ1A"
                     /note="PHD finger found in bromodomain adjacent to zinc
                     finger domain protein 1A (BAZ1A); cd15627"
                     /db_xref="CDD:277097"
     Site            order(1118,1130..1134,1138,1158)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277097"
     Region          1391..1503
                     /region_name="Bromo_Acf1_like"
                     /note="Bromodomain; Acf1_like or BAZ1A_like subfamily.
                     Bromo adjacent to zinc finger 1A (BAZ1A) was identified as
                     a novel human bromodomain gene by cDNA library screening.
                     The Drosophila homologue, Acf1, is part of the CHRAC
                     (chromatin accessibility complex)...; cd05504"
                     /db_xref="CDD:99936"
     Site            order(1426,1431,1434,1473,1477,1483)
                     /site_type="other"
                     /note="putative acetyllysine binding site [chemical
                     binding]"
                     /db_xref="CDD:99936"
     CDS             1..1524
                     /gene="BAZ1A"
                     /gene_synonym="ACF1; hACF1; WALp1; WCRF180"
                     /coded_by="XM_047430887.1:551..5125"
                     /db_xref="GeneID:11177"
                     /db_xref="HGNC:HGNC:960"
                     /db_xref="MIM:605680"
ORIGIN      
        1 mpllhrkpfv rqkppadlrp deevfyckvt neifrhyddf fertilcnsl vwscavtgrp
       61 gltyqeales ekkarqnlqs fpepliipvl yltslthrsr lheicddifa yvkdryfvee
      121 tvevirnnga rlqcrilevl ppshqngfan ghvnsvdget iiisdsddse tqscsfqngk
      181 kkdaidpllf kykvqptkke lhesaivkat qisrrkhlfs rdklklflkq hcepqdgvik
      241 ikasslstyk iaeqdfsyff pddpptfifs panrrrgrpp krihisqedn vankqtlasy
      301 rskatkerdk llkqeemksl afekaklkre kadaleakkk ekedkekkre elkkiveeer
      361 lkkkeekerl kverekerek lreekrkyve ylkqwskpre dmecddlkel peptpvktrl
      421 ppeifgdalm vleflnafge lfdlqdefpd gvtlevleea lvgndsegpl cellffflta
      481 ifqaiaeeee evakeqltda dtkgcslksl dldsctlsei lrlhilasga dvtsanakyr
      541 yqkrggfdat ddacmelrls npslvkklss tsvydltpge kmkilhalcg klltlvstrd
      601 fiedyvdilr qakqefrelk aeqhrkeree aaarirkrke eklkeqeqkm kekqeklked
      661 eqrnstadis igeeeredfd tsieskdteq keldqdmvte deddpgshkr grrgkrgqng
      721 fkeftrqeqi ncvtreplta deeealkqeh qrkekellek iqsaiactni fplgrdrmyr
      781 rywifpsipg lfieedysgl tedmllprps sfqnnvqsqd pqvstktgep lmsestsnid
      841 qgprdhsvql pkpvhkpnrw cfyssceqld qliealnsrg hresalketl lqeksricaq
      901 larfseekfh fsdkpqpdsk ptysrgrssn aydpsqmcae kqlelrlrdf lldiedriyq
      961 gtlgaikvtd rhiwrsales gryellseen kengiiktvn edveemeide qtkvivkdrl
     1021 lgiktetpst vstnastpqs vssvvhylam alfqieqgie rrflkaplda sdsgrsyktv
     1081 ldrwreslls saslsqvflh lstldrsviw sksilnarck icrkkgdaen mvlcdgcdrg
     1141 hhtycvrpkl ktvpegdwfc pecrpkqrsr rlssrqrpsl esdedvedsm ggeddevdgd
     1201 eeegqseeee yeveqdedds qeeeevslpk rgrpqvrlpv ktrgklsssf ssrgqqqepg
     1261 rypsrsqqst pkttvssktg rslrkinsap ptetkslria srstrhshgp lqadvfvell
     1321 sprrkrrgrk sanntpensp nfpnfrviat ksseqsrsvn iasklslqes eskrrcrkrq
     1381 spepspvtlg rrssgrqggv helsafeqlv velvrhddsw pflklvskiq vpdyydiikk
     1441 pialniirek vnkceyklas efiddielmf sncfeynprn tseakagtrl qaffhiqaqk
     1501 lglhvtpsnv dqvstppaak ksri
//
LOCUS       XP_047286844            1523 aa            linear   PRI 05-AUG-2025
DEFINITION  bromodomain adjacent to zinc finger domain protein 1A isoform X3
            [Homo sapiens].
ACCESSION   XP_047286844
VERSION     XP_047286844.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430888.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1523
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1523
                     /product="bromodomain adjacent to zinc finger domain
                     protein 1A isoform X3"
                     /calculated_mol_wt=174519
     Region          6..89
                     /region_name="WAC_Acf1_DNA_bd"
                     /note="ATP-utilizing chromatin assembly and remodelling
                     N-terminal; pfam10537"
                     /db_xref="CDD:463140"
     Region          389..452
                     /region_name="DDT"
                     /note="domain in different transcription and chromosome
                     remodeling factors; smart00571"
                     /db_xref="CDD:214726"
     Region          557..602
                     /region_name="WHIM1"
                     /note="WSTF, HB1, Itc1p, MBD9 motif 1; pfam15612"
                     /db_xref="CDD:464774"
     Region          <612..755
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          767..893
                     /region_name="WSD"
                     /note="Williams-Beuren syndrome DDT (WSD), D-TOX E motif;
                     pfam15613"
                     /db_xref="CDD:464775"
     Region          1117..1162
                     /region_name="PHD_BAZ1A"
                     /note="PHD finger found in bromodomain adjacent to zinc
                     finger domain protein 1A (BAZ1A); cd15627"
                     /db_xref="CDD:277097"
     Site            order(1117,1129..1133,1137,1157)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277097"
     Region          1390..1502
                     /region_name="Bromo_Acf1_like"
                     /note="Bromodomain; Acf1_like or BAZ1A_like subfamily.
                     Bromo adjacent to zinc finger 1A (BAZ1A) was identified as
                     a novel human bromodomain gene by cDNA library screening.
                     The Drosophila homologue, Acf1, is part of the CHRAC
                     (chromatin accessibility complex)...; cd05504"
                     /db_xref="CDD:99936"
     Site            order(1425,1430,1433,1472,1476,1482)
                     /site_type="other"
                     /note="putative acetyllysine binding site [chemical
                     binding]"
                     /db_xref="CDD:99936"
     CDS             1..1523
                     /gene="BAZ1A"
                     /gene_synonym="ACF1; hACF1; WALp1; WCRF180"
                     /coded_by="XM_047430888.1:1507..6078"
                     /db_xref="GeneID:11177"
                     /db_xref="HGNC:HGNC:960"
                     /db_xref="MIM:605680"
ORIGIN      
        1 mrklsdffer tilcnslvws cavtgrpglt yqealesekk arqnlqsfpe pliipvlylt
       61 slthrsrlhe icddifayvk dryfveetve virnngarlq crilevlpps hqngfanghv
      121 nsvdgetiii sdsddsetqs csfqngkkkd aidpllfkyk vqptkkelhe saivkatqis
      181 rrkhlfsrdk lklflkqhce pqdgvikika sslstykiae qdfsyffpdd pptfifspan
      241 rrrgrppkri hisqednvan kqtlasyrsk atkerdkllk qeemkslafe kaklkrekad
      301 aleakkkeke dkekkreelk kiveeerlkk keekerlkve rekereklre ekrkyveylk
      361 qwskpredme cddlkelpep tpvktrlppe ifgdalmvle flnafgelfd lqdefpdgvt
      421 levleealvg ndsegplcel lfffltaifq aiaeeeeeva keqltdadtk dltealdeda
      481 dptksalsav aslaaawpql hqgcslksld ldsctlseil rlhilasgad vtsanakyry
      541 qkrggfdatd dacmelrlsn pslvkklsst svydltpgek mkilhalcgk lltlvstrdf
      601 iedyvdilrq akqefrelka eqhrkereea aarirkrkee klkeqeqkmk ekqeklkede
      661 qrnstadisi geeeredfdt sieskdteqk eldqdmvted eddpgshkrg rrgkrgqngf
      721 keftrqeqin cvtrepltad eeealkqehq rkekelleki qsaiactnif plgrdrmyrr
      781 ywifpsipgl fieedysglt edmllprpss fqnnvqsqdp qvstktgepl msestsnidq
      841 gprdhsvqlp kpvhkpnrwc fyssceqldq liealnsrgh resalketll qeksricaql
      901 arfseekfhf sdkpqpdskp tysrgrssna ydpsqmcaek qlelrlrdfl ldiedriyqg
      961 tlgaikvtdr hiwrsalesg ryellseenk engiiktvne dveemeideq tkvivkdrll
     1021 giktetpstv stnastpqsv ssvvhylama lfqieqgier rflkapldas dsgrsyktvl
     1081 drwresllss aslsqvflhl stldrsviws ksilnarcki crkkgdaenm vlcdgcdrgh
     1141 htycvrpklk tvpegdwfcp ecrpkqrsrr lssrqrpsle sdedvedsmg geddevdgde
     1201 eegqseeeey eveqdeddsq eeeevslpkr grpqvrlpvk trgklsssfs srgqqqepgr
     1261 ypsrsqqstp kttvssktgr slrkinsapp tetkslrias rstrhshgpl qadvfvells
     1321 prrkrrgrks anntpenspn fpnfrviatk sseqsrsvni asklslqese skrrcrkrqs
     1381 pepspvtlgr rssgrqggvh elsafeqlvv elvrhddswp flklvskiqv pdyydiikkp
     1441 ialniirekv nkceyklase fiddielmfs ncfeynprnt seakagtrlq affhiqaqkl
     1501 glhvtpsnvd qvstppaakk sri
//
LOCUS       XP_047286845            1463 aa            linear   PRI 05-AUG-2025
DEFINITION  bromodomain adjacent to zinc finger domain protein 1A isoform X4
            [Homo sapiens].
ACCESSION   XP_047286845
VERSION     XP_047286845.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430889.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1463
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1463
                     /product="bromodomain adjacent to zinc finger domain
                     protein 1A isoform X4"
                     /calculated_mol_wt=167782
     Region          329..392
                     /region_name="DDT"
                     /note="domain in different transcription and chromosome
                     remodeling factors; smart00571"
                     /db_xref="CDD:214726"
     Region          497..542
                     /region_name="WHIM1"
                     /note="WSTF, HB1, Itc1p, MBD9 motif 1; pfam15612"
                     /db_xref="CDD:464774"
     Region          <552..695
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          707..833
                     /region_name="WSD"
                     /note="Williams-Beuren syndrome DDT (WSD), D-TOX E motif;
                     pfam15613"
                     /db_xref="CDD:464775"
     Region          1057..1102
                     /region_name="PHD_BAZ1A"
                     /note="PHD finger found in bromodomain adjacent to zinc
                     finger domain protein 1A (BAZ1A); cd15627"
                     /db_xref="CDD:277097"
     Site            order(1057,1069..1073,1077,1097)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277097"
     Region          1330..1442
                     /region_name="Bromo_Acf1_like"
                     /note="Bromodomain; Acf1_like or BAZ1A_like subfamily.
                     Bromo adjacent to zinc finger 1A (BAZ1A) was identified as
                     a novel human bromodomain gene by cDNA library screening.
                     The Drosophila homologue, Acf1, is part of the CHRAC
                     (chromatin accessibility complex)...; cd05504"
                     /db_xref="CDD:99936"
     Site            order(1365,1370,1373,1412,1416,1422)
                     /site_type="other"
                     /note="putative acetyllysine binding site [chemical
                     binding]"
                     /db_xref="CDD:99936"
     CDS             1..1463
                     /gene="BAZ1A"
                     /gene_synonym="ACF1; hACF1; WALp1; WCRF180"
                     /coded_by="XM_047430889.1:88..4479"
                     /db_xref="GeneID:11177"
                     /db_xref="HGNC:HGNC:960"
                     /db_xref="MIM:605680"
ORIGIN      
        1 mpllhrkpfv rqkppadlrp deevfyckvt neifrhyelq crilevlpps hqngfanghv
       61 nsvdgetiii sdsddsetqs csfqngkkkd aidpllfkyk vqptkkelhe saivkatqis
      121 rrkhlfsrdk lklflkqhce pqdgvikika sslstykiae qdfsyffpdd pptfifspan
      181 rrrgrppkri hisqednvan kqtlasyrsk atkerdkllk qeemkslafe kaklkrekad
      241 aleakkkeke dkekkreelk kiveeerlkk keekerlkve rekereklre ekrkyveylk
      301 qwskpredme cddlkelpep tpvktrlppe ifgdalmvle flnafgelfd lqdefpdgvt
      361 levleealvg ndsegplcel lfffltaifq aiaeeeeeva keqltdadtk dltealdeda
      421 dptksalsav aslaaawpql hqgcslksld ldsctlseil rlhilasgad vtsanakyry
      481 qkrggfdatd dacmelrlsn pslvkklsst svydltpgek mkilhalcgk lltlvstrdf
      541 iedyvdilrq akqefrelka eqhrkereea aarirkrkee klkeqeqkmk ekqeklkede
      601 qrnstadisi geeeredfdt sieskdteqk eldqdmvted eddpgshkrg rrgkrgqngf
      661 keftrqeqin cvtrepltad eeealkqehq rkekelleki qsaiactnif plgrdrmyrr
      721 ywifpsipgl fieedysglt edmllprpss fqnnvqsqdp qvstktgepl msestsnidq
      781 gprdhsvqlp kpvhkpnrwc fyssceqldq liealnsrgh resalketll qeksricaql
      841 arfseekfhf sdkpqpdskp tysrgrssna ydpsqmcaek qlelrlrdfl ldiedriyqg
      901 tlgaikvtdr hiwrsalesg ryellseenk engiiktvne dveemeideq tkvivkdrll
      961 giktetpstv stnastpqsv ssvvhylama lfqieqgier rflkapldas dsgrsyktvl
     1021 drwresllss aslsqvflhl stldrsviws ksilnarcki crkkgdaenm vlcdgcdrgh
     1081 htycvrpklk tvpegdwfcp ecrpkqrsrr lssrqrpsle sdedvedsmg geddevdgde
     1141 eegqseeeey eveqdeddsq eeeevslpkr grpqvrlpvk trgklsssfs srgqqqepgr
     1201 ypsrsqqstp kttvssktgr slrkinsapp tetkslrias rstrhshgpl qadvfvells
     1261 prrkrrgrks anntpenspn fpnfrviatk sseqsrsvni asklslqese skrrcrkrqs
     1321 pepspvtlgr rssgrqggvh elsafeqlvv elvrhddswp flklvskiqv pdyydiikkp
     1381 ialniirekv nkceyklase fiddielmfs ncfeynprnt seakagtrlq affhiqaqkl
     1441 glhvtpsnvd qvstppaakk sri
//
LOCUS       XP_011534678            1152 aa            linear   PRI 05-AUG-2025
DEFINITION  bromodomain adjacent to zinc finger domain protein 1A isoform X5
            [Homo sapiens].
ACCESSION   XP_011534678
VERSION     XP_011534678.3
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536376.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Mar 26, 2018 this sequence version replaced XP_011534678.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1152
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1152
                     /product="bromodomain adjacent to zinc finger domain
                     protein 1A isoform X5"
                     /calculated_mol_wt=131295
     Region          186..231
                     /region_name="WHIM1"
                     /note="WSTF, HB1, Itc1p, MBD9 motif 1; pfam15612"
                     /db_xref="CDD:464774"
     Region          <241..384
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          396..522
                     /region_name="WSD"
                     /note="Williams-Beuren syndrome DDT (WSD), D-TOX E motif;
                     pfam15613"
                     /db_xref="CDD:464775"
     Region          746..791
                     /region_name="PHD_BAZ1A"
                     /note="PHD finger found in bromodomain adjacent to zinc
                     finger domain protein 1A (BAZ1A); cd15627"
                     /db_xref="CDD:277097"
     Site            order(746,758..762,766,786)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277097"
     Region          1019..1131
                     /region_name="Bromo_Acf1_like"
                     /note="Bromodomain; Acf1_like or BAZ1A_like subfamily.
                     Bromo adjacent to zinc finger 1A (BAZ1A) was identified as
                     a novel human bromodomain gene by cDNA library screening.
                     The Drosophila homologue, Acf1, is part of the CHRAC
                     (chromatin accessibility complex)...; cd05504"
                     /db_xref="CDD:99936"
     Site            order(1054,1059,1062,1101,1105,1111)
                     /site_type="other"
                     /note="putative acetyllysine binding site [chemical
                     binding]"
                     /db_xref="CDD:99936"
     CDS             1..1152
                     /gene="BAZ1A"
                     /gene_synonym="ACF1; hACF1; WALp1; WCRF180"
                     /coded_by="XM_011536376.4:127..3585"
                     /db_xref="GeneID:11177"
                     /db_xref="HGNC:HGNC:960"
                     /db_xref="MIM:605680"
ORIGIN      
        1 mwpfisseyl ilimwhlgal rsrkqkllal lkprpgigta lllphsigqs serppwdstg
       61 lwnrlhflsr ewymgvcrqa iaeeeeevak eqltdadtkd ltealdedad ptksalsava
      121 slaaawpqlh qgcslksldl dsctlseilr lhilasgadv tsanakyryq krggfdatdd
      181 acmelrlsnp slvkklssts vydltpgekm kilhalcgkl ltlvstrdfi edyvdilrqa
      241 kqefrelkae qhrkereeaa arirkrkeek lkeqeqkmke kqeklkedeq rnstadisig
      301 eeeredfdts ieskdteqke ldqdmvtede ddpgshkrgr rgkrgqngfk eftrqeqinc
      361 vtrepltade eealkqehqr kekellekiq saiactnifp lgrdrmyrry wifpsipglf
      421 ieedysglte dmllprpssf qnnvqsqdpq vstktgeplm sestsnidqg prdhsvqlpk
      481 pvhkpnrwcf yssceqldql iealnsrghr esalketllq eksricaqla rfseekfhfs
      541 dkpqpdskpt ysrgrssnay dpsqmcaekq lelrlrdfll diedriyqgt lgaikvtdrh
      601 iwrsalesgr yellseenke ngiiktvned veemeideqt kvivkdrllg iktetpstvs
      661 tnastpqsvs svvhylamal fqieqgierr flkapldasd sgrsyktvld rwresllssa
      721 slsqvflhls tldrsviwsk silnarckic rkkgdaenmv lcdgcdrghh tycvrpklkt
      781 vpegdwfcpe crpkqrsrrl ssrqrpsles dedvedsmgg eddevdgdee egqseeeeye
      841 veqdeddsqe eeevslpkrg rpqvrlpvkt rgklsssfss rgqqqepgry psrsqqstpk
      901 ttvssktgrs lrkinsappt etkslriasr strhshgplq advfvellsp rrkrrgrksa
      961 nntpenspnf pnfrviatks seqsrsvnia sklslqeses krrcrkrqsp epspvtlgrr
     1021 ssgrqggvhe lsafeqlvve lvrhddswpf lklvskiqvp dyydiikkpi alniirekvn
     1081 kceyklasef iddielmfsn cfeynprnts eakagtrlqa ffhiqaqklg lhvtpsnvdq
     1141 vstppaakks ri
//
LOCUS       XP_047286846             863 aa            linear   PRI 05-AUG-2025
DEFINITION  mitogen-activated protein kinase kinase kinase kinase 5 isoform X1
            [Homo sapiens].
ACCESSION   XP_047286846
VERSION     XP_047286846.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430890.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..863
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..863
                     /product="mitogen-activated protein kinase kinase kinase
                     kinase 5 isoform X1"
                     /calculated_mol_wt=96952
     Region          10..277
                     /region_name="STKc_MAP4K5"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     Mitogen-activated protein kinase kinase kinase kinase 5;
                     cd06646"
                     /db_xref="CDD:270813"
     Site            order(26..30,34,47,49,78,94..97,100..101,104,140,142..145,
                     147,157..158,161,175..178,180,210,219)
                     /site_type="active"
                     /db_xref="CDD:270813"
     Site            order(26..30,34,47,49,78,94..97,100..101,104,144..145,147,
                     158)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270813"
     Site            order(29..30,140,142..144,161,175..178,180,210,219)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270813"
     Site            157..180
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270813"
     Region          528..843
                     /region_name="CNH"
                     /note="Domain found in NIK1-like kinases, mouse citron and
                     yeast ROM1, ROM2; smart00036"
                     /db_xref="CDD:214481"
     CDS             1..863
                     /gene="MAP4K5"
                     /gene_synonym="GCKR; KHS; KHS1; MAPKKKK5"
                     /coded_by="XM_047430890.1:280..2871"
                     /db_xref="GeneID:11183"
                     /db_xref="HGNC:HGNC:6867"
                     /db_xref="MIM:604923"
ORIGIN      
        1 meaplrpaad ilrrnpqqdy elvqrvgsgt ygdvykarnv htgelaavki iklepgddfs
       61 liqqeifmvk eckhcnivay fgsylsrekl wicmeycggg slqdiyhvtg plselqiayv
      121 cretlqglay lhtkgkmhrd ikganilltd hgdvkladfg vaakitatia krksfigtpy
      181 wmapevaave knggynqlcd iwavgitaie lgelqppmfd lhpmralflm sksnfqppkl
      241 kdktkwsstf hnfvkialtk npkkrptaer llthtfvaqp glsralavel ldkvnnpdnh
      301 ahyteadddd fephaiirht irstnrnara ertaseinyq pfemlslyip viyfavdklq
      361 fepplrkete ardemglssd pnfmlqwnpf vdgantgkst skraippplp pkprissype
      421 dnfpdeekas tikhcpdses rapqilrrqs spscgpvaet ssigngdgis klmsentegs
      481 aqapqlprkk dkrdfpkpai nglpptpkvl mgacfskvfd gcplkincat swihpdtkdq
      541 yiifgtedgi ytlnlnelhe atmeqlfprk ctwlyvinnt lmslsegktf qlyshnlial
      601 fehakkpgla ahiqthrfpd rilprkfalt tkipdtkgch kccivrnpyt ghkylcgalq
      661 sgivllqwye pmqkfmlikh fdfplpspln vfemlvipeq eypmvcvais kgtesnqvvq
      721 fetinlnsas swfteigags qqldsihvtq lerdtvlvcl dkfvkivnlq gklksskkla
      781 selsfdfrie svvclqdsvl afwkhgmqgk sfksdevtqe isdetrvfrl lgsdrvvvle
      841 srptenptah snlyilaghe nsy
//
LOCUS       XP_047286847             863 aa            linear   PRI 05-AUG-2025
DEFINITION  mitogen-activated protein kinase kinase kinase kinase 5 isoform X1
            [Homo sapiens].
ACCESSION   XP_047286847
VERSION     XP_047286847.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430891.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..863
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..863
                     /product="mitogen-activated protein kinase kinase kinase
                     kinase 5 isoform X1"
                     /calculated_mol_wt=96952
     Region          10..277
                     /region_name="STKc_MAP4K5"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     Mitogen-activated protein kinase kinase kinase kinase 5;
                     cd06646"
                     /db_xref="CDD:270813"
     Site            order(26..30,34,47,49,78,94..97,100..101,104,140,142..145,
                     147,157..158,161,175..178,180,210,219)
                     /site_type="active"
                     /db_xref="CDD:270813"
     Site            order(26..30,34,47,49,78,94..97,100..101,104,144..145,147,
                     158)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270813"
     Site            order(29..30,140,142..144,161,175..178,180,210,219)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270813"
     Site            157..180
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270813"
     Region          528..843
                     /region_name="CNH"
                     /note="Domain found in NIK1-like kinases, mouse citron and
                     yeast ROM1, ROM2; smart00036"
                     /db_xref="CDD:214481"
     CDS             1..863
                     /gene="MAP4K5"
                     /gene_synonym="GCKR; KHS; KHS1; MAPKKKK5"
                     /coded_by="XM_047430891.1:218..2809"
                     /db_xref="GeneID:11183"
                     /db_xref="HGNC:HGNC:6867"
                     /db_xref="MIM:604923"
ORIGIN      
        1 meaplrpaad ilrrnpqqdy elvqrvgsgt ygdvykarnv htgelaavki iklepgddfs
       61 liqqeifmvk eckhcnivay fgsylsrekl wicmeycggg slqdiyhvtg plselqiayv
      121 cretlqglay lhtkgkmhrd ikganilltd hgdvkladfg vaakitatia krksfigtpy
      181 wmapevaave knggynqlcd iwavgitaie lgelqppmfd lhpmralflm sksnfqppkl
      241 kdktkwsstf hnfvkialtk npkkrptaer llthtfvaqp glsralavel ldkvnnpdnh
      301 ahyteadddd fephaiirht irstnrnara ertaseinyq pfemlslyip viyfavdklq
      361 fepplrkete ardemglssd pnfmlqwnpf vdgantgkst skraippplp pkprissype
      421 dnfpdeekas tikhcpdses rapqilrrqs spscgpvaet ssigngdgis klmsentegs
      481 aqapqlprkk dkrdfpkpai nglpptpkvl mgacfskvfd gcplkincat swihpdtkdq
      541 yiifgtedgi ytlnlnelhe atmeqlfprk ctwlyvinnt lmslsegktf qlyshnlial
      601 fehakkpgla ahiqthrfpd rilprkfalt tkipdtkgch kccivrnpyt ghkylcgalq
      661 sgivllqwye pmqkfmlikh fdfplpspln vfemlvipeq eypmvcvais kgtesnqvvq
      721 fetinlnsas swfteigags qqldsihvtq lerdtvlvcl dkfvkivnlq gklksskkla
      781 selsfdfrie svvclqdsvl afwkhgmqgk sfksdevtqe isdetrvfrl lgsdrvvvle
      841 srptenptah snlyilaghe nsy
//
LOCUS       XP_047286848             863 aa            linear   PRI 05-AUG-2025
DEFINITION  mitogen-activated protein kinase kinase kinase kinase 5 isoform X1
            [Homo sapiens].
ACCESSION   XP_047286848
VERSION     XP_047286848.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430892.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..863
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..863
                     /product="mitogen-activated protein kinase kinase kinase
                     kinase 5 isoform X1"
                     /calculated_mol_wt=96952
     Region          10..277
                     /region_name="STKc_MAP4K5"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     Mitogen-activated protein kinase kinase kinase kinase 5;
                     cd06646"
                     /db_xref="CDD:270813"
     Site            order(26..30,34,47,49,78,94..97,100..101,104,140,142..145,
                     147,157..158,161,175..178,180,210,219)
                     /site_type="active"
                     /db_xref="CDD:270813"
     Site            order(26..30,34,47,49,78,94..97,100..101,104,144..145,147,
                     158)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270813"
     Site            order(29..30,140,142..144,161,175..178,180,210,219)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270813"
     Site            157..180
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270813"
     Region          528..843
                     /region_name="CNH"
                     /note="Domain found in NIK1-like kinases, mouse citron and
                     yeast ROM1, ROM2; smart00036"
                     /db_xref="CDD:214481"
     CDS             1..863
                     /gene="MAP4K5"
                     /gene_synonym="GCKR; KHS; KHS1; MAPKKKK5"
                     /coded_by="XM_047430892.1:232..2823"
                     /db_xref="GeneID:11183"
                     /db_xref="HGNC:HGNC:6867"
                     /db_xref="MIM:604923"
ORIGIN      
        1 meaplrpaad ilrrnpqqdy elvqrvgsgt ygdvykarnv htgelaavki iklepgddfs
       61 liqqeifmvk eckhcnivay fgsylsrekl wicmeycggg slqdiyhvtg plselqiayv
      121 cretlqglay lhtkgkmhrd ikganilltd hgdvkladfg vaakitatia krksfigtpy
      181 wmapevaave knggynqlcd iwavgitaie lgelqppmfd lhpmralflm sksnfqppkl
      241 kdktkwsstf hnfvkialtk npkkrptaer llthtfvaqp glsralavel ldkvnnpdnh
      301 ahyteadddd fephaiirht irstnrnara ertaseinyq pfemlslyip viyfavdklq
      361 fepplrkete ardemglssd pnfmlqwnpf vdgantgkst skraippplp pkprissype
      421 dnfpdeekas tikhcpdses rapqilrrqs spscgpvaet ssigngdgis klmsentegs
      481 aqapqlprkk dkrdfpkpai nglpptpkvl mgacfskvfd gcplkincat swihpdtkdq
      541 yiifgtedgi ytlnlnelhe atmeqlfprk ctwlyvinnt lmslsegktf qlyshnlial
      601 fehakkpgla ahiqthrfpd rilprkfalt tkipdtkgch kccivrnpyt ghkylcgalq
      661 sgivllqwye pmqkfmlikh fdfplpspln vfemlvipeq eypmvcvais kgtesnqvvq
      721 fetinlnsas swfteigags qqldsihvtq lerdtvlvcl dkfvkivnlq gklksskkla
      781 selsfdfrie svvclqdsvl afwkhgmqgk sfksdevtqe isdetrvfrl lgsdrvvvle
      841 srptenptah snlyilaghe nsy
//
LOCUS       XP_047286849             863 aa            linear   PRI 05-AUG-2025
DEFINITION  mitogen-activated protein kinase kinase kinase kinase 5 isoform X1
            [Homo sapiens].
ACCESSION   XP_047286849
VERSION     XP_047286849.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430893.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..863
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..863
                     /product="mitogen-activated protein kinase kinase kinase
                     kinase 5 isoform X1"
                     /calculated_mol_wt=96952
     Region          10..277
                     /region_name="STKc_MAP4K5"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     Mitogen-activated protein kinase kinase kinase kinase 5;
                     cd06646"
                     /db_xref="CDD:270813"
     Site            order(26..30,34,47,49,78,94..97,100..101,104,140,142..145,
                     147,157..158,161,175..178,180,210,219)
                     /site_type="active"
                     /db_xref="CDD:270813"
     Site            order(26..30,34,47,49,78,94..97,100..101,104,144..145,147,
                     158)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270813"
     Site            order(29..30,140,142..144,161,175..178,180,210,219)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270813"
     Site            157..180
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270813"
     Region          528..843
                     /region_name="CNH"
                     /note="Domain found in NIK1-like kinases, mouse citron and
                     yeast ROM1, ROM2; smart00036"
                     /db_xref="CDD:214481"
     CDS             1..863
                     /gene="MAP4K5"
                     /gene_synonym="GCKR; KHS; KHS1; MAPKKKK5"
                     /coded_by="XM_047430893.1:283..2874"
                     /db_xref="GeneID:11183"
                     /db_xref="HGNC:HGNC:6867"
                     /db_xref="MIM:604923"
ORIGIN      
        1 meaplrpaad ilrrnpqqdy elvqrvgsgt ygdvykarnv htgelaavki iklepgddfs
       61 liqqeifmvk eckhcnivay fgsylsrekl wicmeycggg slqdiyhvtg plselqiayv
      121 cretlqglay lhtkgkmhrd ikganilltd hgdvkladfg vaakitatia krksfigtpy
      181 wmapevaave knggynqlcd iwavgitaie lgelqppmfd lhpmralflm sksnfqppkl
      241 kdktkwsstf hnfvkialtk npkkrptaer llthtfvaqp glsralavel ldkvnnpdnh
      301 ahyteadddd fephaiirht irstnrnara ertaseinyq pfemlslyip viyfavdklq
      361 fepplrkete ardemglssd pnfmlqwnpf vdgantgkst skraippplp pkprissype
      421 dnfpdeekas tikhcpdses rapqilrrqs spscgpvaet ssigngdgis klmsentegs
      481 aqapqlprkk dkrdfpkpai nglpptpkvl mgacfskvfd gcplkincat swihpdtkdq
      541 yiifgtedgi ytlnlnelhe atmeqlfprk ctwlyvinnt lmslsegktf qlyshnlial
      601 fehakkpgla ahiqthrfpd rilprkfalt tkipdtkgch kccivrnpyt ghkylcgalq
      661 sgivllqwye pmqkfmlikh fdfplpspln vfemlvipeq eypmvcvais kgtesnqvvq
      721 fetinlnsas swfteigags qqldsihvtq lerdtvlvcl dkfvkivnlq gklksskkla
      781 selsfdfrie svvclqdsvl afwkhgmqgk sfksdevtqe isdetrvfrl lgsdrvvvle
      841 srptenptah snlyilaghe nsy
//
LOCUS       XP_047286850             862 aa            linear   PRI 05-AUG-2025
DEFINITION  mitogen-activated protein kinase kinase kinase kinase 5 isoform X2
            [Homo sapiens].
ACCESSION   XP_047286850
VERSION     XP_047286850.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430894.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..862
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..862
                     /product="mitogen-activated protein kinase kinase kinase
                     kinase 5 isoform X2"
                     /calculated_mol_wt=96823
     Region          10..277
                     /region_name="STKc_MAP4K5"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     Mitogen-activated protein kinase kinase kinase kinase 5;
                     cd06646"
                     /db_xref="CDD:270813"
     Site            order(26..30,34,47,49,78,94..97,100..101,104,140,142..145,
                     147,157..158,161,175..178,180,210,219)
                     /site_type="active"
                     /db_xref="CDD:270813"
     Site            order(26..30,34,47,49,78,94..97,100..101,104,144..145,147,
                     158)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270813"
     Site            order(29..30,140,142..144,161,175..178,180,210,219)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270813"
     Site            157..180
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270813"
     Region          528..842
                     /region_name="CNH"
                     /note="Domain found in NIK1-like kinases, mouse citron and
                     yeast ROM1, ROM2; smart00036"
                     /db_xref="CDD:214481"
     CDS             1..862
                     /gene="MAP4K5"
                     /gene_synonym="GCKR; KHS; KHS1; MAPKKKK5"
                     /coded_by="XM_047430894.1:280..2868"
                     /db_xref="GeneID:11183"
                     /db_xref="HGNC:HGNC:6867"
                     /db_xref="MIM:604923"
ORIGIN      
        1 meaplrpaad ilrrnpqqdy elvqrvgsgt ygdvykarnv htgelaavki iklepgddfs
       61 liqqeifmvk eckhcnivay fgsylsrekl wicmeycggg slqdiyhvtg plselqiayv
      121 cretlqglay lhtkgkmhrd ikganilltd hgdvkladfg vaakitatia krksfigtpy
      181 wmapevaave knggynqlcd iwavgitaie lgelqppmfd lhpmralflm sksnfqppkl
      241 kdktkwsstf hnfvkialtk npkkrptaer llthtfvaqp glsralavel ldkvnnpdnh
      301 ahyteadddd fephaiirht irstnrnara ertaseinyq pfemlslyip viyfavdklq
      361 fepplrkete ardemglssd pnfmlqwnpf vdgantgkst skraippplp pkprissype
      421 dnfpdeekas tikhcpdses rapqilrrqs spscgpvaet ssigngdgis klmsentegs
      481 aqapqlprkk dkrdfpkpai nglpptpkvl mgacfskvfd gcplkincat swihpdtkdq
      541 yiifgtedgi ytlnlnelhe atmeqlfprk ctwlyvinnt lmslsgktfq lyshnlialf
      601 ehakkpglaa hiqthrfpdr ilprkfaltt kipdtkgchk ccivrnpytg hkylcgalqs
      661 givllqwyep mqkfmlikhf dfplpsplnv femlvipeqe ypmvcvaisk gtesnqvvqf
      721 etinlnsass wfteigagsq qldsihvtql erdtvlvcld kfvkivnlqg klksskklas
      781 elsfdfries vvclqdsvla fwkhgmqgks fksdevtqei sdetrvfrll gsdrvvvles
      841 rptenptahs nlyilaghen sy
//
LOCUS       XP_006720076             846 aa            linear   PRI 05-AUG-2025
DEFINITION  mitogen-activated protein kinase kinase kinase kinase 5 isoform X3
            [Homo sapiens].
ACCESSION   XP_006720076
VERSION     XP_006720076.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720013.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..846
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..846
                     /product="mitogen-activated protein kinase kinase kinase
                     kinase 5 isoform X3"
                     /calculated_mol_wt=94923
     Region          10..277
                     /region_name="STKc_MAP4K5"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     Mitogen-activated protein kinase kinase kinase kinase 5;
                     cd06646"
                     /db_xref="CDD:270813"
     Site            order(26..30,34,47,49,78,94..97,100..101,104,140,142..145,
                     147,157..158,161,175..178,180,210,219)
                     /site_type="active"
                     /db_xref="CDD:270813"
     Site            order(26..30,34,47,49,78,94..97,100..101,104,144..145,147,
                     158)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270813"
     Site            order(29..30,140,142..144,161,175..178,180,210,219)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270813"
     Site            157..180
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270813"
     Region          511..826
                     /region_name="CNH"
                     /note="Domain found in NIK1-like kinases, mouse citron and
                     yeast ROM1, ROM2; smart00036"
                     /db_xref="CDD:214481"
     CDS             1..846
                     /gene="MAP4K5"
                     /gene_synonym="GCKR; KHS; KHS1; MAPKKKK5"
                     /coded_by="XM_006720013.5:218..2758"
                     /db_xref="GeneID:11183"
                     /db_xref="HGNC:HGNC:6867"
                     /db_xref="MIM:604923"
ORIGIN      
        1 meaplrpaad ilrrnpqqdy elvqrvgsgt ygdvykarnv htgelaavki iklepgddfs
       61 liqqeifmvk eckhcnivay fgsylsrekl wicmeycggg slqdiyhvtg plselqiayv
      121 cretlqglay lhtkgkmhrd ikganilltd hgdvkladfg vaakitatia krksfigtpy
      181 wmapevaave knggynqlcd iwavgitaie lgelqppmfd lhpmralflm sksnfqppkl
      241 kdktkwsstf hnfvkialtk npkkrptaer llthtfvaqp glsralavel ldkvnnpdnh
      301 ahyteadddd fephaiirht irstnrnara ertaseinfd klqfepplrk eteardemgl
      361 ssdpnfmlqw npfvdgantg kstskraipp plppkpriss ypednfpdee kastikhcpd
      421 sesrapqilr rqsspscgpv aetssigngd gisklmsent egsaqapqlp rkkdkrdfpk
      481 painglpptp kvlmgacfsk vfdgcplkin catswihpdt kdqyiifgte dgiytlnlne
      541 lheatmeqlf prkctwlyvi nntlmslseg ktfqlyshnl ialfehakkp glaahiqthr
      601 fpdrilprkf alttkipdtk gchkccivrn pytghkylcg alqsgivllq wyepmqkfml
      661 ikhfdfplps plnvfemlvi peqeypmvcv aiskgtesnq vvqfetinln sasswfteig
      721 agsqqldsih vtqlerdtvl vcldkfvkiv nlqgklkssk klaselsfdf riesvvclqd
      781 svlafwkhgm qgksfksdev tqeisdetrv frllgsdrvv vlesrptenp tahsnlyila
      841 ghensy
//
LOCUS       XP_011534679             845 aa            linear   PRI 05-AUG-2025
DEFINITION  mitogen-activated protein kinase kinase kinase kinase 5 isoform X4
            [Homo sapiens].
ACCESSION   XP_011534679
VERSION     XP_011534679.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536377.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..845
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..845
                     /product="mitogen-activated protein kinase kinase kinase
                     kinase 5 isoform X4"
                     /calculated_mol_wt=94794
     Region          10..277
                     /region_name="STKc_MAP4K5"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     Mitogen-activated protein kinase kinase kinase kinase 5;
                     cd06646"
                     /db_xref="CDD:270813"
     Site            order(26..30,34,47,49,78,94..97,100..101,104,140,142..145,
                     147,157..158,161,175..178,180,210,219)
                     /site_type="active"
                     /db_xref="CDD:270813"
     Site            order(26..30,34,47,49,78,94..97,100..101,104,144..145,147,
                     158)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270813"
     Site            order(29..30,140,142..144,161,175..178,180,210,219)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270813"
     Site            157..180
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270813"
     Region          511..825
                     /region_name="CNH"
                     /note="Domain found in NIK1-like kinases, mouse citron and
                     yeast ROM1, ROM2; smart00036"
                     /db_xref="CDD:214481"
     CDS             1..845
                     /gene="MAP4K5"
                     /gene_synonym="GCKR; KHS; KHS1; MAPKKKK5"
                     /coded_by="XM_011536377.4:232..2769"
                     /db_xref="GeneID:11183"
                     /db_xref="HGNC:HGNC:6867"
                     /db_xref="MIM:604923"
ORIGIN      
        1 meaplrpaad ilrrnpqqdy elvqrvgsgt ygdvykarnv htgelaavki iklepgddfs
       61 liqqeifmvk eckhcnivay fgsylsrekl wicmeycggg slqdiyhvtg plselqiayv
      121 cretlqglay lhtkgkmhrd ikganilltd hgdvkladfg vaakitatia krksfigtpy
      181 wmapevaave knggynqlcd iwavgitaie lgelqppmfd lhpmralflm sksnfqppkl
      241 kdktkwsstf hnfvkialtk npkkrptaer llthtfvaqp glsralavel ldkvnnpdnh
      301 ahyteadddd fephaiirht irstnrnara ertaseinfd klqfepplrk eteardemgl
      361 ssdpnfmlqw npfvdgantg kstskraipp plppkpriss ypednfpdee kastikhcpd
      421 sesrapqilr rqsspscgpv aetssigngd gisklmsent egsaqapqlp rkkdkrdfpk
      481 painglpptp kvlmgacfsk vfdgcplkin catswihpdt kdqyiifgte dgiytlnlne
      541 lheatmeqlf prkctwlyvi nntlmslsgk tfqlyshnli alfehakkpg laahiqthrf
      601 pdrilprkfa lttkipdtkg chkccivrnp ytghkylcga lqsgivllqw yepmqkfmli
      661 khfdfplpsp lnvfemlvip eqeypmvcva iskgtesnqv vqfetinlns asswfteiga
      721 gsqqldsihv tqlerdtvlv cldkfvkivn lqgklksskk laselsfdfr iesvvclqds
      781 vlafwkhgmq gksfksdevt qeisdetrvf rllgsdrvvv lesrptenpt ahsnlyilag
      841 hensy
//
LOCUS       XP_047286851             845 aa            linear   PRI 05-AUG-2025
DEFINITION  mitogen-activated protein kinase kinase kinase kinase 5 isoform X4
            [Homo sapiens].
ACCESSION   XP_047286851
VERSION     XP_047286851.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430895.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..845
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..845
                     /product="mitogen-activated protein kinase kinase kinase
                     kinase 5 isoform X4"
                     /calculated_mol_wt=94794
     Region          10..277
                     /region_name="STKc_MAP4K5"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     Mitogen-activated protein kinase kinase kinase kinase 5;
                     cd06646"
                     /db_xref="CDD:270813"
     Site            order(26..30,34,47,49,78,94..97,100..101,104,140,142..145,
                     147,157..158,161,175..178,180,210,219)
                     /site_type="active"
                     /db_xref="CDD:270813"
     Site            order(26..30,34,47,49,78,94..97,100..101,104,144..145,147,
                     158)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270813"
     Site            order(29..30,140,142..144,161,175..178,180,210,219)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270813"
     Site            157..180
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270813"
     Region          511..825
                     /region_name="CNH"
                     /note="Domain found in NIK1-like kinases, mouse citron and
                     yeast ROM1, ROM2; smart00036"
                     /db_xref="CDD:214481"
     CDS             1..845
                     /gene="MAP4K5"
                     /gene_synonym="GCKR; KHS; KHS1; MAPKKKK5"
                     /coded_by="XM_047430895.1:280..2817"
                     /db_xref="GeneID:11183"
                     /db_xref="HGNC:HGNC:6867"
                     /db_xref="MIM:604923"
ORIGIN      
        1 meaplrpaad ilrrnpqqdy elvqrvgsgt ygdvykarnv htgelaavki iklepgddfs
       61 liqqeifmvk eckhcnivay fgsylsrekl wicmeycggg slqdiyhvtg plselqiayv
      121 cretlqglay lhtkgkmhrd ikganilltd hgdvkladfg vaakitatia krksfigtpy
      181 wmapevaave knggynqlcd iwavgitaie lgelqppmfd lhpmralflm sksnfqppkl
      241 kdktkwsstf hnfvkialtk npkkrptaer llthtfvaqp glsralavel ldkvnnpdnh
      301 ahyteadddd fephaiirht irstnrnara ertaseinfd klqfepplrk eteardemgl
      361 ssdpnfmlqw npfvdgantg kstskraipp plppkpriss ypednfpdee kastikhcpd
      421 sesrapqilr rqsspscgpv aetssigngd gisklmsent egsaqapqlp rkkdkrdfpk
      481 painglpptp kvlmgacfsk vfdgcplkin catswihpdt kdqyiifgte dgiytlnlne
      541 lheatmeqlf prkctwlyvi nntlmslsgk tfqlyshnli alfehakkpg laahiqthrf
      601 pdrilprkfa lttkipdtkg chkccivrnp ytghkylcga lqsgivllqw yepmqkfmli
      661 khfdfplpsp lnvfemlvip eqeypmvcva iskgtesnqv vqfetinlns asswfteiga
      721 gsqqldsihv tqlerdtvlv cldkfvkivn lqgklksskk laselsfdfr iesvvclqds
      781 vlafwkhgmq gksfksdevt qeisdetrvf rllgsdrvvv lesrptenpt ahsnlyilag
      841 hensy
//
LOCUS       XP_047286852             845 aa            linear   PRI 05-AUG-2025
DEFINITION  mitogen-activated protein kinase kinase kinase kinase 5 isoform X4
            [Homo sapiens].
ACCESSION   XP_047286852
VERSION     XP_047286852.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430896.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..845
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..845
                     /product="mitogen-activated protein kinase kinase kinase
                     kinase 5 isoform X4"
                     /calculated_mol_wt=94794
     Region          10..277
                     /region_name="STKc_MAP4K5"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     Mitogen-activated protein kinase kinase kinase kinase 5;
                     cd06646"
                     /db_xref="CDD:270813"
     Site            order(26..30,34,47,49,78,94..97,100..101,104,140,142..145,
                     147,157..158,161,175..178,180,210,219)
                     /site_type="active"
                     /db_xref="CDD:270813"
     Site            order(26..30,34,47,49,78,94..97,100..101,104,144..145,147,
                     158)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270813"
     Site            order(29..30,140,142..144,161,175..178,180,210,219)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270813"
     Site            157..180
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270813"
     Region          511..825
                     /region_name="CNH"
                     /note="Domain found in NIK1-like kinases, mouse citron and
                     yeast ROM1, ROM2; smart00036"
                     /db_xref="CDD:214481"
     CDS             1..845
                     /gene="MAP4K5"
                     /gene_synonym="GCKR; KHS; KHS1; MAPKKKK5"
                     /coded_by="XM_047430896.1:218..2755"
                     /db_xref="GeneID:11183"
                     /db_xref="HGNC:HGNC:6867"
                     /db_xref="MIM:604923"
ORIGIN      
        1 meaplrpaad ilrrnpqqdy elvqrvgsgt ygdvykarnv htgelaavki iklepgddfs
       61 liqqeifmvk eckhcnivay fgsylsrekl wicmeycggg slqdiyhvtg plselqiayv
      121 cretlqglay lhtkgkmhrd ikganilltd hgdvkladfg vaakitatia krksfigtpy
      181 wmapevaave knggynqlcd iwavgitaie lgelqppmfd lhpmralflm sksnfqppkl
      241 kdktkwsstf hnfvkialtk npkkrptaer llthtfvaqp glsralavel ldkvnnpdnh
      301 ahyteadddd fephaiirht irstnrnara ertaseinfd klqfepplrk eteardemgl
      361 ssdpnfmlqw npfvdgantg kstskraipp plppkpriss ypednfpdee kastikhcpd
      421 sesrapqilr rqsspscgpv aetssigngd gisklmsent egsaqapqlp rkkdkrdfpk
      481 painglpptp kvlmgacfsk vfdgcplkin catswihpdt kdqyiifgte dgiytlnlne
      541 lheatmeqlf prkctwlyvi nntlmslsgk tfqlyshnli alfehakkpg laahiqthrf
      601 pdrilprkfa lttkipdtkg chkccivrnp ytghkylcga lqsgivllqw yepmqkfmli
      661 khfdfplpsp lnvfemlvip eqeypmvcva iskgtesnqv vqfetinlns asswfteiga
      721 gsqqldsihv tqlerdtvlv cldkfvkivn lqgklksskk laselsfdfr iesvvclqds
      781 vlafwkhgmq gksfksdevt qeisdetrvf rllgsdrvvv lesrptenpt ahsnlyilag
      841 hensy
//
LOCUS       XP_047286853             845 aa            linear   PRI 05-AUG-2025
DEFINITION  mitogen-activated protein kinase kinase kinase kinase 5 isoform X4
            [Homo sapiens].
ACCESSION   XP_047286853
VERSION     XP_047286853.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430897.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..845
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..845
                     /product="mitogen-activated protein kinase kinase kinase
                     kinase 5 isoform X4"
                     /calculated_mol_wt=94794
     Region          10..277
                     /region_name="STKc_MAP4K5"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     Mitogen-activated protein kinase kinase kinase kinase 5;
                     cd06646"
                     /db_xref="CDD:270813"
     Site            order(26..30,34,47,49,78,94..97,100..101,104,140,142..145,
                     147,157..158,161,175..178,180,210,219)
                     /site_type="active"
                     /db_xref="CDD:270813"
     Site            order(26..30,34,47,49,78,94..97,100..101,104,144..145,147,
                     158)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270813"
     Site            order(29..30,140,142..144,161,175..178,180,210,219)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270813"
     Site            157..180
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270813"
     Region          511..825
                     /region_name="CNH"
                     /note="Domain found in NIK1-like kinases, mouse citron and
                     yeast ROM1, ROM2; smart00036"
                     /db_xref="CDD:214481"
     CDS             1..845
                     /gene="MAP4K5"
                     /gene_synonym="GCKR; KHS; KHS1; MAPKKKK5"
                     /coded_by="XM_047430897.1:283..2820"
                     /db_xref="GeneID:11183"
                     /db_xref="HGNC:HGNC:6867"
                     /db_xref="MIM:604923"
ORIGIN      
        1 meaplrpaad ilrrnpqqdy elvqrvgsgt ygdvykarnv htgelaavki iklepgddfs
       61 liqqeifmvk eckhcnivay fgsylsrekl wicmeycggg slqdiyhvtg plselqiayv
      121 cretlqglay lhtkgkmhrd ikganilltd hgdvkladfg vaakitatia krksfigtpy
      181 wmapevaave knggynqlcd iwavgitaie lgelqppmfd lhpmralflm sksnfqppkl
      241 kdktkwsstf hnfvkialtk npkkrptaer llthtfvaqp glsralavel ldkvnnpdnh
      301 ahyteadddd fephaiirht irstnrnara ertaseinfd klqfepplrk eteardemgl
      361 ssdpnfmlqw npfvdgantg kstskraipp plppkpriss ypednfpdee kastikhcpd
      421 sesrapqilr rqsspscgpv aetssigngd gisklmsent egsaqapqlp rkkdkrdfpk
      481 painglpptp kvlmgacfsk vfdgcplkin catswihpdt kdqyiifgte dgiytlnlne
      541 lheatmeqlf prkctwlyvi nntlmslsgk tfqlyshnli alfehakkpg laahiqthrf
      601 pdrilprkfa lttkipdtkg chkccivrnp ytghkylcga lqsgivllqw yepmqkfmli
      661 khfdfplpsp lnvfemlvip eqeypmvcva iskgtesnqv vqfetinlns asswfteiga
      721 gsqqldsihv tqlerdtvlv cldkfvkivn lqgklksskk laselsfdfr iesvvclqds
      781 vlafwkhgmq gksfksdevt qeisdetrvf rllgsdrvvv lesrptenpt ahsnlyilag
      841 hensy
//
LOCUS       XP_047286854             796 aa            linear   PRI 05-AUG-2025
DEFINITION  mitogen-activated protein kinase kinase kinase kinase 5 isoform X5
            [Homo sapiens].
ACCESSION   XP_047286854
VERSION     XP_047286854.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430898.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..796
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..796
                     /product="mitogen-activated protein kinase kinase kinase
                     kinase 5 isoform X5"
                     /calculated_mol_wt=89427
     Region          1..210
                     /region_name="STKc_MAP4K3_like"
                     /note="Catalytic domain of Mitogen-activated protein
                     kinase kinase kinase kinase (MAP4K) 3-like
                     Serine/Threonine Kinases; cd06613"
                     /db_xref="CDD:270788"
     Site            order(73,75..77,94,108..111,113,143,152)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270788"
     Site            order(90..101,104..113)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270788"
     Region          461..776
                     /region_name="CNH"
                     /note="Domain found in NIK1-like kinases, mouse citron and
                     yeast ROM1, ROM2; smart00036"
                     /db_xref="CDD:214481"
     CDS             1..796
                     /gene="MAP4K5"
                     /gene_synonym="GCKR; KHS; KHS1; MAPKKKK5"
                     /coded_by="XM_047430898.1:267..2657"
                     /db_xref="GeneID:11183"
                     /db_xref="HGNC:HGNC:6867"
                     /db_xref="MIM:604923"
ORIGIN      
        1 mvkeckhcni vayfgsylsr eklwicmeyc gggslqdiyh vtgplselqi ayvcretlqg
       61 laylhtkgkm hrdikganil ltdhgdvkla dfgvaakita tiakrksfig tpywmapeva
      121 aveknggynq lcdiwavgit aielgelqpp mfdlhpmral flmsksnfqp pklkdktkws
      181 stfhnfvkia ltknpkkrpt aerllthtfv aqpglsrala velldkvnnp dnhahytead
      241 dddfephaii rhtirstnrn araertasei nyqpfemlsl yipviyfavd klqfepplrk
      301 eteardemgl ssdpnfmlqw npfvdgantg kstskraipp plppkpriss ypednfpdee
      361 kastikhcpd sesrapqilr rqsspscgpv aetssigngd gisklmsent egsaqapqlp
      421 rkkdkrdfpk painglpptp kvlmgacfsk vfdgcplkin catswihpdt kdqyiifgte
      481 dgiytlnlne lheatmeqlf prkctwlyvi nntlmslseg ktfqlyshnl ialfehakkp
      541 glaahiqthr fpdrilprkf alttkipdtk gchkccivrn pytghkylcg alqsgivllq
      601 wyepmqkfml ikhfdfplps plnvfemlvi peqeypmvcv aiskgtesnq vvqfetinln
      661 sasswfteig agsqqldsih vtqlerdtvl vcldkfvkiv nlqgklkssk klaselsfdf
      721 riesvvclqd svlafwkhgm qgksfksdev tqeisdetrv frllgsdrvv vlesrptenp
      781 tahsnlyila ghensy
//
LOCUS       XP_011534682             557 aa            linear   PRI 05-AUG-2025
DEFINITION  mitogen-activated protein kinase kinase kinase kinase 5 isoform X6
            [Homo sapiens].
ACCESSION   XP_011534682
VERSION     XP_011534682.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536380.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..557
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..557
                     /product="mitogen-activated protein kinase kinase kinase
                     kinase 5 isoform X6"
                     /calculated_mol_wt=62580
     Region          222..537
                     /region_name="CNH"
                     /note="Domain found in NIK1-like kinases, mouse citron and
                     yeast ROM1, ROM2; smart00036"
                     /db_xref="CDD:214481"
     CDS             1..557
                     /gene="MAP4K5"
                     /gene_synonym="GCKR; KHS; KHS1; MAPKKKK5"
                     /coded_by="XM_011536380.4:1830..3503"
                     /db_xref="GeneID:11183"
                     /db_xref="HGNC:HGNC:6867"
                     /db_xref="MIM:604923"
ORIGIN      
        1 mlghylfkis apvsllcfwd ssyirkntec clqvvealys hytllhvstl dklqfepplr
       61 keteardemg lssdpnfmlq wnpfvdgant gkstskraip pplppkpris sypednfpde
      121 ekastikhcp dsesrapqil rrqsspscgp vaetssigng dgisklmsen tegsaqapql
      181 prkkdkrdfp kpainglppt pkvlmgacfs kvfdgcplki ncatswihpd tkdqyiifgt
      241 edgiytlnln elheatmeql fprkctwlyv inntlmslse gktfqlyshn lialfehakk
      301 pglaahiqth rfpdrilprk falttkipdt kgchkccivr npytghkylc galqsgivll
      361 qwyepmqkfm likhfdfplp splnvfemlv ipeqeypmvc vaiskgtesn qvvqfetinl
      421 nsasswftei gagsqqldsi hvtqlerdtv lvcldkfvki vnlqgklkss kklaselsfd
      481 friesvvclq dsvlafwkhg mqgksfksde vtqeisdetr vfrllgsdrv vvlesrpten
      541 ptahsnlyil aghensy
//
LOCUS       XP_047286855             982 aa            linear   PRI 05-AUG-2025
DEFINITION  FACT complex subunit SPT16 isoform X1 [Homo sapiens].
ACCESSION   XP_047286855
VERSION     XP_047286855.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430899.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..982
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..982
                     /product="FACT complex subunit SPT16 isoform X1"
                     /calculated_mol_wt=112261
     Region          5..936
                     /region_name="COG5406"
                     /note="Nucleosome binding factor SPN, SPT16 subunit
                     [Transcription, Replication, recombination and repair,
                     Chromatin structure and dynamics]"
                     /db_xref="CDD:227693"
     CDS             1..982
                     /gene="SUPT16H"
                     /gene_synonym="CDC68; FACTP140; NEDDFAC; SPT16;
                     SPT16/CDC68"
                     /coded_by="XM_047430899.1:265..3213"
                     /db_xref="GeneID:11198"
                     /db_xref="HGNC:HGNC:11465"
                     /db_xref="MIM:605012"
ORIGIN      
        1 mvfcddkiif maskkkvefl kqiantkgne nangapaitl lireknesnk ssfdkmieai
       61 keskngkkig vfskdkfpge fmkswndcln kegfdkidis avvaytiavk edgelnlmkk
      121 aasitsevfn kffkervmei vdadekvrhs klaesvekai eekkylagad pstvemcypp
      181 iiqsggnynl kfsvvsdknh mhfgaitcam girfksycsn lvrtlmvdps qevqenynfl
      241 lqlqeellke lrhgvkicdv ynavmdvvkk qkpellnkit knlgfgmgie fregslvins
      301 knqyklkkgm vfsinlgfsd ltnkegkkpe ektyalfigd tvlvdedgpa tvltsvkkkv
      361 knvgiflkne deeeeeeekd eaedllgrgs raalltertr nemtaeekrr ahqkelaaql
      421 neeakrrlte qkgeqqiqka rksnvsyknp slmpkephir emkiyidkky etvimpvfgi
      481 atpfhiatik nismsvegdy tylrinfycp gsalgrnegn ifpnpeatfv keityrasni
      541 kapgeqtvpa lnlqnafrii kevqkryktr eaeekekegi vkqdslvinl nrsnpklkdl
      601 yirpniaqkr mqgsleahvn gfrftsvrgd kvdilynnik halfqpcdge miivlhfhlk
      661 naimfgkkrh tdvqfytevg eittdlgkhq hmhdrddlya eqmeremrhk lktafknfie
      721 kvealtkeel efevpfrdlg fngapyrstc llqptssalv natewppfvv tldevelihf
      781 ervqfhlknf dmvivykdys kkvtminaip vasldpikew lnscdlkyte gvqslnwtki
      841 mktivddpeg ffeqggwsfl epegegsdae egdseseied etfnpseddy eeeeedsded
      901 ysseaeesdy skeslgseee sgkdwdelee earkadresr yeeeeeqsrs msrkrkasvh
      961 ssgrgsnrgs rhssappkkk rk
//
LOCUS       XP_011534685             425 aa            linear   PRI 05-AUG-2025
DEFINITION  WD repeat-containing protein 89 isoform X1 [Homo sapiens].
ACCESSION   XP_011534685
VERSION     XP_011534685.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536383.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..425
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..425
                     /product="WD repeat-containing protein 89 isoform X1"
                     /calculated_mol_wt=47092
     Region          79..387
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Site            order(83,87,93..94,106..107,125,129,135..136,150..151,169,
                     178,184..185,207,225,230,236..237,253,272,276,282..283,
                     298..299,330,335,341..342,357..358,376,380,386..387)
                     /site_type="active"
                     /note="structural tetrad [active]"
                     /db_xref="CDD:238121"
     Region          112..150
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          156..198
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          212..250
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          257..297
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          305..355
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          362..386
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..425
                     /gene="WDR89"
                     /gene_synonym="C14orf150; MSTP050"
                     /coded_by="XM_011536383.3:189..1466"
                     /db_xref="GeneID:112840"
                     /db_xref="HGNC:HGNC:20489"
ORIGIN      
        1 mqtcrerilq anscccspea gasltcsrvl lpldaavdme kieeqfanlh ivkcslgtke
       61 ptyllgidts ktvqagkenl vavlcsngsi riydkerlnv lrefsgypgl lngvrfansc
      121 dsvysactdg tvkcwdarva rekpvqlfkg ypsnifisfd incndhiica gtekvdddal
      181 lvfwdarmns qnlsttkdsl gaysethsdd vtqvrfhpsn pnmvvsgssd glvnvfdini
      241 dneedalvtt cnsissvsci gwsgkgykqi ycmthdegfy wwdlnhldtd epvtrlniqd
      301 vrevvnmked aldyliggly hektdtlhvi ggtnkgrihl mncsmsglth vtslqgghaa
      361 tvrsfcwnvq ddslltgged aqlllwkpga iektftkkes mkiassvhqr vrvhsndsyk
      421 rrkkq
//
LOCUS       XP_047286856             340 aa            linear   PRI 05-AUG-2025
DEFINITION  trans-3-hydroxy-L-proline dehydratase isoform X1 [Homo sapiens].
ACCESSION   XP_047286856
VERSION     XP_047286856.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430900.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..340
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..340
                     /product="trans-3-hydroxy-L-proline dehydratase isoform
                     X1"
                     /calculated_mol_wt=36560
     Region          22..313
                     /region_name="Pro_racemase"
                     /note="Proline racemase; cl42407"
                     /db_xref="CDD:478179"
     CDS             1..340
                     /gene="L3HYPDH"
                     /gene_synonym="C14orf149"
                     /coded_by="XM_047430900.1:93..1115"
                     /db_xref="GeneID:112849"
                     /db_xref="HGNC:HGNC:20488"
                     /db_xref="MIM:614811"
ORIGIN      
        1 mesalavprl pphdpgtpvl svvdmhtgge plrivlagcp evsgptllak rrymrqhldh
       61 vrrrlmfepr ghrdmygavl vpselpdahl gvlflhnegy ssmcghavla lgrfaldfgl
      121 vpappagtre arvnihcpcg lvtafvaced grshgpvrfh svpafvlatd lmvdvpghgk
      181 vmvdiaygga fyafvtaekl gldicsaktr dlvdaasavt eavkaqfkin hpdsedlafl
      241 ygtiltdgkd aytkepttni cvfadeqvdr sptgsgvtar ialqyhkgll elnqmrafks
      301 satgsvftgk avripflpvy tksthrkqsa ppttpqkacl
//
LOCUS       XP_047286858             324 aa            linear   PRI 05-AUG-2025
DEFINITION  trans-3-hydroxy-L-proline dehydratase isoform X2 [Homo sapiens].
ACCESSION   XP_047286858
VERSION     XP_047286858.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430902.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..324
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..324
                     /product="trans-3-hydroxy-L-proline dehydratase isoform
                     X2"
                     /calculated_mol_wt=34732
     Region          22..313
                     /region_name="Pro_racemase"
                     /note="Proline racemase; cl42407"
                     /db_xref="CDD:478179"
     CDS             1..324
                     /gene="L3HYPDH"
                     /gene_synonym="C14orf149"
                     /coded_by="XM_047430902.1:93..1067"
                     /db_xref="GeneID:112849"
                     /db_xref="HGNC:HGNC:20488"
                     /db_xref="MIM:614811"
ORIGIN      
        1 mesalavprl pphdpgtpvl svvdmhtgge plrivlagcp evsgptllak rrymrqhldh
       61 vrrrlmfepr ghrdmygavl vpselpdahl gvlflhnegy ssmcghavla lgrfaldfgl
      121 vpappagtre arvnihcpcg lvtafvaced grshgpvrfh svpafvlatd lmvdvpghgk
      181 vmvdiaygga fyafvtaekl gldicsaktr dlvdaasavt eavkaqfkin hpdsedlafl
      241 ygtiltdgkd aytkepttni cvfadeqvdr sptgsgvtar ialqyhkgll elnqmrafks
      301 satgsvftgk avrsvqwgss eatm
//
LOCUS       XP_047286859             316 aa            linear   PRI 05-AUG-2025
DEFINITION  trans-3-hydroxy-L-proline dehydratase isoform X3 [Homo sapiens].
ACCESSION   XP_047286859
VERSION     XP_047286859.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430903.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..316
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..316
                     /product="trans-3-hydroxy-L-proline dehydratase isoform
                     X3"
                     /calculated_mol_wt=33923
     Region          22..314
                     /region_name="Pro_racemase"
                     /note="Proline racemase; cl42407"
                     /db_xref="CDD:478179"
     CDS             1..316
                     /gene="L3HYPDH"
                     /gene_synonym="C14orf149"
                     /coded_by="XM_047430903.1:93..1043"
                     /db_xref="GeneID:112849"
                     /db_xref="HGNC:HGNC:20488"
                     /db_xref="MIM:614811"
ORIGIN      
        1 mesalavprl pphdpgtpvl svvdmhtgge plrivlagcp evsgptllak rrymrqhldh
       61 vrrrlmfepr ghrdmygavl vpselpdahl gvlflhnegy ssmcghavla lgrfaldfgl
      121 vpappagtre arvnihcpcg lvtafvaced grshgpvrfh svpafvlatd lmvdvpghgk
      181 vmvdiaygga fyafvtaekl gldicsaktr dlvdaasavt eavkaqfkin hpdsedlafl
      241 ygtiltdgkd aytkepttni cvfadeqvdr sptgsgvtar ialqyhkgll elnqmrafks
      301 satgsvftgk avrell
//
LOCUS       XP_024305230             183 aa            linear   PRI 05-AUG-2025
DEFINITION  trans-3-hydroxy-L-proline dehydratase isoform X4 [Homo sapiens].
ACCESSION   XP_024305230
VERSION     XP_024305230.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449462.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..183
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..183
                     /product="trans-3-hydroxy-L-proline dehydratase isoform
                     X4"
                     /calculated_mol_wt=19503
     Region          <1..181
                     /region_name="Pro_racemase"
                     /note="Proline racemase; cl42407"
                     /db_xref="CDD:478179"
     CDS             1..183
                     /gene="L3HYPDH"
                     /gene_synonym="C14orf149"
                     /coded_by="XM_024449462.2:91..642"
                     /db_xref="GeneID:112849"
                     /db_xref="HGNC:HGNC:20488"
                     /db_xref="MIM:614811"
ORIGIN      
        1 mvdvpghgkv mvdiayggaf yafvtaeklg ldicsaktrd lvdaasavte avkaqfkinh
       61 pdsedlafly gtiltdgkda ytkepttnic vfadeqvdrs ptgsgvtari alqyhkglle
      121 lnqmrafkss atgsvftgka vreakcgdfk avivevsgqa hytgtasfii edddplrdgf
      181 llk
//
LOCUS       XP_024305231            5695 aa            linear   PRI 05-AUG-2025
DEFINITION  protein AHNAK2 isoform X1 [Homo sapiens].
ACCESSION   XP_024305231
VERSION     XP_024305231.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449463.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..5695
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..5695
                     /product="protein AHNAK2 isoform X1"
                     /calculated_mol_wt=605520
     Region          25..81
                     /region_name="PDZ_canonical"
                     /note="canonical PDZ domain; cl49608"
                     /db_xref="CDD:483948"
     Site            order(25..29,39,42,71,75,78..79)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467234"
     Region          <327..577
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          754..1356
                     /region_name="TamB"
                     /note="Autotransporter translocation and assembly protein
                     TamB [Intracellular trafficking, secretion, and vesicular
                     transport]; COG2911"
                     /db_xref="CDD:442155"
     Region          <1329..1715
                     /region_name="AsmA"
                     /note="Uncharacterized conserved protein AsmA involved in
                     outer membrane biogenesis [Cell wall/membrane/envelope
                     biogenesis]; COG2982"
                     /db_xref="CDD:442221"
     Region          <1659..2045
                     /region_name="AsmA"
                     /note="Uncharacterized conserved protein AsmA involved in
                     outer membrane biogenesis [Cell wall/membrane/envelope
                     biogenesis]; COG2982"
                     /db_xref="CDD:442221"
     Region          2256..2703
                     /region_name="AsmA"
                     /note="Uncharacterized conserved protein AsmA involved in
                     outer membrane biogenesis [Cell wall/membrane/envelope
                     biogenesis]; COG2982"
                     /db_xref="CDD:442221"
     Region          <2641..3035
                     /region_name="AsmA"
                     /note="Uncharacterized conserved protein AsmA involved in
                     outer membrane biogenesis [Cell wall/membrane/envelope
                     biogenesis]; COG2982"
                     /db_xref="CDD:442221"
     Region          <2979..3284
                     /region_name="AsmA"
                     /note="Uncharacterized conserved protein AsmA involved in
                     outer membrane biogenesis [Cell wall/membrane/envelope
                     biogenesis]; COG2982"
                     /db_xref="CDD:442221"
     Region          3228..>3732
                     /region_name="TamB"
                     /note="Autotransporter translocation and assembly protein
                     TamB [Intracellular trafficking, secretion, and vesicular
                     transport]; COG2911"
                     /db_xref="CDD:442155"
     Region          3890..>4427
                     /region_name="TamB"
                     /note="Autotransporter translocation and assembly protein
                     TamB [Intracellular trafficking, secretion, and vesicular
                     transport]; COG2911"
                     /db_xref="CDD:442155"
     CDS             1..5695
                     /gene="AHNAK2"
                     /gene_synonym="C14orf78"
                     /coded_by="XM_024449463.2:439..17526"
                     /db_xref="GeneID:113146"
                     /db_xref="HGNC:HGNC:20125"
                     /db_xref="MIM:608570"
ORIGIN      
        1 msrpeavqea tevtlkteve agasgysvtg ggdqgifvkq vlkdssaakl fnlregdqll
       61 sttvffenik yedalkilqy sepykvqfki rrqlpapqde ewassdaqhg pqgkekedtd
      121 vadgcretpt ktlegdgdqe rliskprvgr grqsqrerls wpkfqsiksk rgpgpqrshs
      181 sseayeprda hdvsptstdt eaqltverqe qkagpgsqrr rkflnlrfrt gsgqgpsstg
      241 qpgrgfqsgv gragvleelg pwgdsleetg aatgsrreer aeqdrevmpa qsmplptelg
      301 dprlcegtpq egglraarlh gktlegqaqe tavaqrkpra qptpgmsreg egeglqslei
      361 giarlslrdt teggtqigpp eirvrvhdlk tpkfafstek epererrlst pqrgkrqdas
      421 skagtglkge evegagwmpg reptthaeaq gdegdgeegl qrtriteeqd kgredtegqi
      481 rmpkfkipsl gwspskhtkt grekatedte qgregeatat adrreqrrte eglkdkedsd
      541 smtnttkiql ihdekrlkke qiltekevat kdskfkmpkf kmplfgasap gksmeasvdv
      601 sapkveadvs llsmqgdlkt tdlsvqtpsa dlevqdgqvd vklpegplpe gaslkghlpk
      661 vqrpslkmpk vdlkgpkldl kgpkaevtap dvkmslssme vdvqaprakl dgarlegdls
      721 ladkevtakd skfkmpkfkm psfgvsapgk smedsvdvsa pkveadvsls smqgdlkatd
      781 lsiqppsadl evqagqvdvk lpegpvpega gpkvhlpkve mpsfkmpkvd lkgpqidvkg
      841 pkldlkgpka evtapdgevs lpsmevdvqa qkakldgawl egdlsladkd vtakdskfkm
      901 pkfkmpsfgv sapgksikal vdvsapkvea dlslpsmqgd lkttdlsiqp astdlkvqad
      961 qvdvklpegh lpegaglkgh lpkvempsfk mpkvalkgpq vdvkgpkldl kspkaevtap
     1021 dvevslpsve vdveapgakl dsarlegels ladkdvtakd srfkmpkfkm psfgasapgk
     1081 sieasvdvsa pkveadvslp smqgdlkttd lsiqppsadl evhagqvdvk lleghvpega
     1141 gfkghlpkvq mpslkmpkvd lkgpqvevrg pkldlkghka evtahevavs lpsvevdmqa
     1201 pgakldgaql dgdlsladkd vtakdskfkm pkfkmpsfgv sapgksieas vdlsapkvea
     1261 dmslpsmqgd lkttdlsiqp pstdlelqag qldvklpegp vpegaglkgh lpklqmpsfk
     1321 vpkvdlkgpe idikgpkldl kdpkvevtap dvevslpsve vdveapgakl dggrleedms
     1381 ladkdlttkd skfkmpkfkm psfgvsapgk sieasvdvsa pkveadvslp smqgdlkatd
     1441 lsiqppsadl evqagqvdvk lpegpvsega glkghlpkvq mpsfkmpkvd lkgpqidvkg
     1501 pkldlkgpkv evtapdvkms lssmevdvqa prakldgaql egdlsladka vtakdskfkm
     1561 pkfkmpsfgv sapgksieas vdvsepkvea dvslpsmqgd lkttdlsiqs psadlevqag
     1621 qvnvklpegp lpegagfkgh lpkvqmpslk mpkvalkgpq mdvkgpkldl kgpkaevmap
     1681 dvevslpsve vdveapgakl dsvrlegdls ladkdvtakd skfkmpkfkm psfgvsapgk
     1741 sieasvdvsa pkveaevslp smqgdlkttd lciplpsadl vvqagqvdmk lpegqvpega
     1801 glkghlpkvd mpsfkmpkvd lkgpqtdvkg akldlkgpka evtapdvevs lpsmevdvqa
     1861 qkakldgarl egdlsladkd mtakdskfkm pkfkmpsfgv sapgrsieas vdvpapkvea
     1921 dvslpsmqgd lkttdlsiqp psadlkvqtg qvdvklpegh vpegaglkgh lpkvempslk
     1981 mpkvdlkgpq vdikgpkldl kdpkvemrvp dvevslpsme vdvqaprakl dsahlqgdlt
     2041 lankdlttkd skfkmpkfkm psfgvsapgk sieasvdvsp pkveadmslp smqgdlkttd
     2101 lsiqplsadv kvqagqvdvk llegpvpeev glkghlpklq mpsfkvpkvd lkgpeidikg
     2161 pkldlkdpkv evtapdvevs lpsvevdvka pgakldgarl egdmsladkd vtakdskfkm
     2221 pkfkmlsfgv salgksieas advsalkvea dvslpsmqgd lkttdlsvqp psadlevqag
     2281 qvdvklpegp vpegaglkgh lpklqmpsfk mpkvdlkgpq idvkgpkldl kgpktdvmap
     2341 dvevsqpsve vdveapgakl dgawlegdls vadkdvttkd srfkipkfkm psfgvsapgk
     2401 sieasvdvsa pkveadgsls smqgdlkatd lsiqppsadl evqagqvdvk lpegpvpega
     2461 glkghlpkvq mpsfkmpemd lkgpqldvkg pkldlkgpka evtapdvems lssmevdvqa
     2521 prakldgarl egdlsladkg vtakdskfkm pkfkmpsfrv sapgesieal vdvselkvea
     2581 dmslpsmqgd lkttdisiqp psaqlevqag qvdvklpegh vpegaglkgh lpklqmpsfk
     2641 mpevdlkgpq idvkgpnvdl kgpkaevtap dvkmslssme vdvqaprakl dgarlegdls
     2701 ladkgmtakd skfkmpkfkm psfgvsapgk sieasvdvse lkveadgsfp smqgdlkttd
     2761 iriqppsaql evqagqvdvk lpeghvpega glkghlpkvq mpsfkmpkvd lkgpqidvkg
     2821 pkldlkgpka evtapdvevs lpsvevdvea prakldgarl egdlsladkd vtakdskfkm
     2881 pkfkmpsfgv sapgksievs vdvsapkvea evslpsmqgd lkttdisiep psaqlevqag
     2941 qvdlklpegh vpegaglkgh lpklqmpsfk mpkvdrkgpq idvkgpkldl kgpktdvtap
     3001 dvevsqpgme vdveapgakl dgarlegdls ladkdvtakd skfkmpkfkm psfgvsapgk
     3061 sievlvdvsa pkveadlslp smqgdlkntd isieppsaql evqagqvdvk lpeghvlega
     3121 glkghlpklq mpsfkmpkvd rkgpqidikg pkldlkgpkm dvtapdvevs qpsmevdvea
     3181 pgakldgarl egdlsladkd vtakdskfkm pkfkmpsyra sapgksiqas vdvsapkaea
     3241 dvslpsmqgd lkttdlsiql psvdlevqag qvdvklpegh vpegaglkgh lpkvempsfk
     3301 mpkvdlkspq vdikgpkldl kvpkaevtvp dvevslpsve vdvqaprakl dgarlegdls
     3361 laekdvtakd skfkmpkfkm psfgvsapgr sieasldvsa pkveadvsls smqgdlkatd
     3421 lsiqppsadl evqavqvdve llegpvpega glkghlpkve mpslktpkvd lkgpqidvkg
     3481 pkldlkgpka evrvpdvevs lpsvevdvqa pkakldagrl egdlsladkd vtakdskfkm
     3541 pkfkmpsfrv sapgksmeas vdvsapkvea dvslpsmqgd lkttdlsiqp psadlkvqag
     3601 qmdvklpegq vpegaglkeh lpkvempslk mpkvdlkgpq vdikgpkldl kvskaevtap
     3661 dvevslpsve vdvqaprakl dsaqlegdls ladkdvtakd skfkmpkfkm psfgvsapgk
     3721 sieasvhvsa pkveadvslp smqgdlkttd lsiqphsadl tvqarqvdmk lleghvpeea
     3781 glkghlpkvq mpsfkmpkvd lkgpeidikg pkldlkdpkv evtapdvevs lpsvevdvea
     3841 pgakldgarl egdlsladkd mtakdskfkm pkfkmpsfgv sapgksmeas vdvtapkvea
     3901 dvslpsmqgd lkatdlsvqp psadlevqag qvdvklpegp vpegaslkgh lpkvqmpsfk
     3961 mpkvdlkgpq idvkgpkldl kgpkaevtap dvkmslssme vdvqaprakl dgvqlegdls
     4021 ladkdvtakd skfkmpkfkm psfgvsapgk smeasvdvse lkakadvslp smqgdlkttd
     4081 lsiqspsadl evqagqvdvk lpegplpkga glkghlpkvq mpclkmpkva lkgpqvdvkg
     4141 pkldlkgpka dvmtpvvevs lpsmevdvea pgakldsvrl egdlsladkd mtakdskfkm
     4201 pkfkmpsfgv sapgksieas ldvsalkvea dvslpsmqgd lktthlsiqp psadlevqag
     4261 qedvklpegp vhegaglkgh lpklqmpsfk vpkvdlkgpq idvnvpkldl kgpkvevtsp
     4321 nldvslpsme vdiqapgakl dstrlegdls ladkdvtakd skfkmpkfkm psfgmlspgk
     4381 sievsvdvsa pkmeadmsip smqgdlkttd lriqapsadl evqagqvdlk lpeghmpeva
     4441 glkghlpkve mpsfkmpkvd lkgpqvdvkg pkldlkgpka evmapdvevs lpsvetdvqa
     4501 pgsmldgarl egdlslahed vagkdskfqg pklstsgfew sskkvsmsss eiegnvtfhe
     4561 ktstfpives vvhegdlhdp srdgnlglav gevgmdskfk klhfkvpkvs fsstktpkds
     4621 lvpgakssig lstiplssse cssfelqqvs acsepsmqmp kvgfagfpss rldltgphfe
     4681 ssilspcedv tltkyqvtvp raalapelal eipsgsqadi plpktecstd lqppegvpts
     4741 qaeshsgpln smipvslgqv sfpkfykpkf vfsvpqmavp egdlhaavga pvmsplspge
     4801 rvqcplpstq lpspgtcvsq gpeelvaslq tsvvapgeap sedadhegkg splkmpkikl
     4861 psfrwspkke tgpkvdpecs vedsklslvl dkdevapqsa ihmdlpperd gekgrstkpg
     4921 fampklalpk mkasksgvsl pqrdvdpsls sataggsfqd tekassdggr gglgatasat
     4981 gsegvnlhrp qvhipslgfa kpdlrsskak vevsqpeadl plpkhdlste gdsrgcglgd
     5041 vpvsqpcgeg iaptpedplq pscrkpdaev ltvespeeea mtkysqeswf kmpkfrmpsl
     5101 rrsfrdrgga gklevaqtqa paatggeaaa kvkeflvsgs nveaamslql peadaevtas
     5161 esksstdilr cdldstglkl hlstagmtgd elstsevrih pskgplpfqm pgmrlpetqv
     5221 lpgeidetpl skpghdlasm edktekwssq pegplklkas stdmpsqisv vnvdqlweds
     5281 vltvkfpklm vprfsfpaps seddvfiptv revqcpeani dtalckespg lwgasilkag
     5341 agvpgeqpvd lnlpleappi skvrvhiqga qvesqevtih sivtpefvdl svprtfstqi
     5401 vreseiptse iqtpsygfsl lkvkipepht qarvyttmtq hsrtqegtee apiqatpgvd
     5461 sisgdlqpdt gepfemisss vnvlgqqtlt fevpsghqla dscsdeepae ilefppddsq
     5521 eattpladeg rapkdkpesk ksgllwfwlp nigfsssvde tgvdskndvq rsapiqtqpe
     5581 arpeaelpkk qekagwfrfp klgfsssptk kskstedgae leeqklqeet itffdaresf
     5641 speekeegel igpvgtglds rvmvtsaart elilpeqdrk addeskgsgl gpneg
//
LOCUS       XP_047286860            5695 aa            linear   PRI 05-AUG-2025
DEFINITION  protein AHNAK2 isoform X1 [Homo sapiens].
ACCESSION   XP_047286860
VERSION     XP_047286860.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430904.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..5695
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..5695
                     /product="protein AHNAK2 isoform X1"
                     /calculated_mol_wt=605520
     Region          25..81
                     /region_name="PDZ_canonical"
                     /note="canonical PDZ domain; cl49608"
                     /db_xref="CDD:483948"
     Site            order(25..29,39,42,71,75,78..79)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467234"
     Region          <327..577
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          754..1356
                     /region_name="TamB"
                     /note="Autotransporter translocation and assembly protein
                     TamB [Intracellular trafficking, secretion, and vesicular
                     transport]; COG2911"
                     /db_xref="CDD:442155"
     Region          <1329..1715
                     /region_name="AsmA"
                     /note="Uncharacterized conserved protein AsmA involved in
                     outer membrane biogenesis [Cell wall/membrane/envelope
                     biogenesis]; COG2982"
                     /db_xref="CDD:442221"
     Region          <1659..2045
                     /region_name="AsmA"
                     /note="Uncharacterized conserved protein AsmA involved in
                     outer membrane biogenesis [Cell wall/membrane/envelope
                     biogenesis]; COG2982"
                     /db_xref="CDD:442221"
     Region          2256..2703
                     /region_name="AsmA"
                     /note="Uncharacterized conserved protein AsmA involved in
                     outer membrane biogenesis [Cell wall/membrane/envelope
                     biogenesis]; COG2982"
                     /db_xref="CDD:442221"
     Region          <2641..3035
                     /region_name="AsmA"
                     /note="Uncharacterized conserved protein AsmA involved in
                     outer membrane biogenesis [Cell wall/membrane/envelope
                     biogenesis]; COG2982"
                     /db_xref="CDD:442221"
     Region          <2979..3284
                     /region_name="AsmA"
                     /note="Uncharacterized conserved protein AsmA involved in
                     outer membrane biogenesis [Cell wall/membrane/envelope
                     biogenesis]; COG2982"
                     /db_xref="CDD:442221"
     Region          3228..>3732
                     /region_name="TamB"
                     /note="Autotransporter translocation and assembly protein
                     TamB [Intracellular trafficking, secretion, and vesicular
                     transport]; COG2911"
                     /db_xref="CDD:442155"
     Region          3890..>4427
                     /region_name="TamB"
                     /note="Autotransporter translocation and assembly protein
                     TamB [Intracellular trafficking, secretion, and vesicular
                     transport]; COG2911"
                     /db_xref="CDD:442155"
     CDS             1..5695
                     /gene="AHNAK2"
                     /gene_synonym="C14orf78"
                     /coded_by="XM_047430904.1:3793..20880"
                     /db_xref="GeneID:113146"
                     /db_xref="HGNC:HGNC:20125"
                     /db_xref="MIM:608570"
ORIGIN      
        1 msrpeavqea tevtlkteve agasgysvtg ggdqgifvkq vlkdssaakl fnlregdqll
       61 sttvffenik yedalkilqy sepykvqfki rrqlpapqde ewassdaqhg pqgkekedtd
      121 vadgcretpt ktlegdgdqe rliskprvgr grqsqrerls wpkfqsiksk rgpgpqrshs
      181 sseayeprda hdvsptstdt eaqltverqe qkagpgsqrr rkflnlrfrt gsgqgpsstg
      241 qpgrgfqsgv gragvleelg pwgdsleetg aatgsrreer aeqdrevmpa qsmplptelg
      301 dprlcegtpq egglraarlh gktlegqaqe tavaqrkpra qptpgmsreg egeglqslei
      361 giarlslrdt teggtqigpp eirvrvhdlk tpkfafstek epererrlst pqrgkrqdas
      421 skagtglkge evegagwmpg reptthaeaq gdegdgeegl qrtriteeqd kgredtegqi
      481 rmpkfkipsl gwspskhtkt grekatedte qgregeatat adrreqrrte eglkdkedsd
      541 smtnttkiql ihdekrlkke qiltekevat kdskfkmpkf kmplfgasap gksmeasvdv
      601 sapkveadvs llsmqgdlkt tdlsvqtpsa dlevqdgqvd vklpegplpe gaslkghlpk
      661 vqrpslkmpk vdlkgpkldl kgpkaevtap dvkmslssme vdvqaprakl dgarlegdls
      721 ladkevtakd skfkmpkfkm psfgvsapgk smedsvdvsa pkveadvsls smqgdlkatd
      781 lsiqppsadl evqagqvdvk lpegpvpega gpkvhlpkve mpsfkmpkvd lkgpqidvkg
      841 pkldlkgpka evtapdgevs lpsmevdvqa qkakldgawl egdlsladkd vtakdskfkm
      901 pkfkmpsfgv sapgksikal vdvsapkvea dlslpsmqgd lkttdlsiqp astdlkvqad
      961 qvdvklpegh lpegaglkgh lpkvempsfk mpkvalkgpq vdvkgpkldl kspkaevtap
     1021 dvevslpsve vdveapgakl dsarlegels ladkdvtakd srfkmpkfkm psfgasapgk
     1081 sieasvdvsa pkveadvslp smqgdlkttd lsiqppsadl evhagqvdvk lleghvpega
     1141 gfkghlpkvq mpslkmpkvd lkgpqvevrg pkldlkghka evtahevavs lpsvevdmqa
     1201 pgakldgaql dgdlsladkd vtakdskfkm pkfkmpsfgv sapgksieas vdlsapkvea
     1261 dmslpsmqgd lkttdlsiqp pstdlelqag qldvklpegp vpegaglkgh lpklqmpsfk
     1321 vpkvdlkgpe idikgpkldl kdpkvevtap dvevslpsve vdveapgakl dggrleedms
     1381 ladkdlttkd skfkmpkfkm psfgvsapgk sieasvdvsa pkveadvslp smqgdlkatd
     1441 lsiqppsadl evqagqvdvk lpegpvsega glkghlpkvq mpsfkmpkvd lkgpqidvkg
     1501 pkldlkgpkv evtapdvkms lssmevdvqa prakldgaql egdlsladka vtakdskfkm
     1561 pkfkmpsfgv sapgksieas vdvsepkvea dvslpsmqgd lkttdlsiqs psadlevqag
     1621 qvnvklpegp lpegagfkgh lpkvqmpslk mpkvalkgpq mdvkgpkldl kgpkaevmap
     1681 dvevslpsve vdveapgakl dsvrlegdls ladkdvtakd skfkmpkfkm psfgvsapgk
     1741 sieasvdvsa pkveaevslp smqgdlkttd lciplpsadl vvqagqvdmk lpegqvpega
     1801 glkghlpkvd mpsfkmpkvd lkgpqtdvkg akldlkgpka evtapdvevs lpsmevdvqa
     1861 qkakldgarl egdlsladkd mtakdskfkm pkfkmpsfgv sapgrsieas vdvpapkvea
     1921 dvslpsmqgd lkttdlsiqp psadlkvqtg qvdvklpegh vpegaglkgh lpkvempslk
     1981 mpkvdlkgpq vdikgpkldl kdpkvemrvp dvevslpsme vdvqaprakl dsahlqgdlt
     2041 lankdlttkd skfkmpkfkm psfgvsapgk sieasvdvsp pkveadmslp smqgdlkttd
     2101 lsiqplsadv kvqagqvdvk llegpvpeev glkghlpklq mpsfkvpkvd lkgpeidikg
     2161 pkldlkdpkv evtapdvevs lpsvevdvka pgakldgarl egdmsladkd vtakdskfkm
     2221 pkfkmlsfgv salgksieas advsalkvea dvslpsmqgd lkttdlsvqp psadlevqag
     2281 qvdvklpegp vpegaglkgh lpklqmpsfk mpkvdlkgpq idvkgpkldl kgpktdvmap
     2341 dvevsqpsve vdveapgakl dgawlegdls vadkdvttkd srfkipkfkm psfgvsapgk
     2401 sieasvdvsa pkveadgsls smqgdlkatd lsiqppsadl evqagqvdvk lpegpvpega
     2461 glkghlpkvq mpsfkmpemd lkgpqldvkg pkldlkgpka evtapdvems lssmevdvqa
     2521 prakldgarl egdlsladkg vtakdskfkm pkfkmpsfrv sapgesieal vdvselkvea
     2581 dmslpsmqgd lkttdisiqp psaqlevqag qvdvklpegh vpegaglkgh lpklqmpsfk
     2641 mpevdlkgpq idvkgpnvdl kgpkaevtap dvkmslssme vdvqaprakl dgarlegdls
     2701 ladkgmtakd skfkmpkfkm psfgvsapgk sieasvdvse lkveadgsfp smqgdlkttd
     2761 iriqppsaql evqagqvdvk lpeghvpega glkghlpkvq mpsfkmpkvd lkgpqidvkg
     2821 pkldlkgpka evtapdvevs lpsvevdvea prakldgarl egdlsladkd vtakdskfkm
     2881 pkfkmpsfgv sapgksievs vdvsapkvea evslpsmqgd lkttdisiep psaqlevqag
     2941 qvdlklpegh vpegaglkgh lpklqmpsfk mpkvdrkgpq idvkgpkldl kgpktdvtap
     3001 dvevsqpgme vdveapgakl dgarlegdls ladkdvtakd skfkmpkfkm psfgvsapgk
     3061 sievlvdvsa pkveadlslp smqgdlkntd isieppsaql evqagqvdvk lpeghvlega
     3121 glkghlpklq mpsfkmpkvd rkgpqidikg pkldlkgpkm dvtapdvevs qpsmevdvea
     3181 pgakldgarl egdlsladkd vtakdskfkm pkfkmpsyra sapgksiqas vdvsapkaea
     3241 dvslpsmqgd lkttdlsiql psvdlevqag qvdvklpegh vpegaglkgh lpkvempsfk
     3301 mpkvdlkspq vdikgpkldl kvpkaevtvp dvevslpsve vdvqaprakl dgarlegdls
     3361 laekdvtakd skfkmpkfkm psfgvsapgr sieasldvsa pkveadvsls smqgdlkatd
     3421 lsiqppsadl evqavqvdve llegpvpega glkghlpkve mpslktpkvd lkgpqidvkg
     3481 pkldlkgpka evrvpdvevs lpsvevdvqa pkakldagrl egdlsladkd vtakdskfkm
     3541 pkfkmpsfrv sapgksmeas vdvsapkvea dvslpsmqgd lkttdlsiqp psadlkvqag
     3601 qmdvklpegq vpegaglkeh lpkvempslk mpkvdlkgpq vdikgpkldl kvskaevtap
     3661 dvevslpsve vdvqaprakl dsaqlegdls ladkdvtakd skfkmpkfkm psfgvsapgk
     3721 sieasvhvsa pkveadvslp smqgdlkttd lsiqphsadl tvqarqvdmk lleghvpeea
     3781 glkghlpkvq mpsfkmpkvd lkgpeidikg pkldlkdpkv evtapdvevs lpsvevdvea
     3841 pgakldgarl egdlsladkd mtakdskfkm pkfkmpsfgv sapgksmeas vdvtapkvea
     3901 dvslpsmqgd lkatdlsvqp psadlevqag qvdvklpegp vpegaslkgh lpkvqmpsfk
     3961 mpkvdlkgpq idvkgpkldl kgpkaevtap dvkmslssme vdvqaprakl dgvqlegdls
     4021 ladkdvtakd skfkmpkfkm psfgvsapgk smeasvdvse lkakadvslp smqgdlkttd
     4081 lsiqspsadl evqagqvdvk lpegplpkga glkghlpkvq mpclkmpkva lkgpqvdvkg
     4141 pkldlkgpka dvmtpvvevs lpsmevdvea pgakldsvrl egdlsladkd mtakdskfkm
     4201 pkfkmpsfgv sapgksieas ldvsalkvea dvslpsmqgd lktthlsiqp psadlevqag
     4261 qedvklpegp vhegaglkgh lpklqmpsfk vpkvdlkgpq idvnvpkldl kgpkvevtsp
     4321 nldvslpsme vdiqapgakl dstrlegdls ladkdvtakd skfkmpkfkm psfgmlspgk
     4381 sievsvdvsa pkmeadmsip smqgdlkttd lriqapsadl evqagqvdlk lpeghmpeva
     4441 glkghlpkve mpsfkmpkvd lkgpqvdvkg pkldlkgpka evmapdvevs lpsvetdvqa
     4501 pgsmldgarl egdlslahed vagkdskfqg pklstsgfew sskkvsmsss eiegnvtfhe
     4561 ktstfpives vvhegdlhdp srdgnlglav gevgmdskfk klhfkvpkvs fsstktpkds
     4621 lvpgakssig lstiplssse cssfelqqvs acsepsmqmp kvgfagfpss rldltgphfe
     4681 ssilspcedv tltkyqvtvp raalapelal eipsgsqadi plpktecstd lqppegvpts
     4741 qaeshsgpln smipvslgqv sfpkfykpkf vfsvpqmavp egdlhaavga pvmsplspge
     4801 rvqcplpstq lpspgtcvsq gpeelvaslq tsvvapgeap sedadhegkg splkmpkikl
     4861 psfrwspkke tgpkvdpecs vedsklslvl dkdevapqsa ihmdlpperd gekgrstkpg
     4921 fampklalpk mkasksgvsl pqrdvdpsls sataggsfqd tekassdggr gglgatasat
     4981 gsegvnlhrp qvhipslgfa kpdlrsskak vevsqpeadl plpkhdlste gdsrgcglgd
     5041 vpvsqpcgeg iaptpedplq pscrkpdaev ltvespeeea mtkysqeswf kmpkfrmpsl
     5101 rrsfrdrgga gklevaqtqa paatggeaaa kvkeflvsgs nveaamslql peadaevtas
     5161 esksstdilr cdldstglkl hlstagmtgd elstsevrih pskgplpfqm pgmrlpetqv
     5221 lpgeidetpl skpghdlasm edktekwssq pegplklkas stdmpsqisv vnvdqlweds
     5281 vltvkfpklm vprfsfpaps seddvfiptv revqcpeani dtalckespg lwgasilkag
     5341 agvpgeqpvd lnlpleappi skvrvhiqga qvesqevtih sivtpefvdl svprtfstqi
     5401 vreseiptse iqtpsygfsl lkvkipepht qarvyttmtq hsrtqegtee apiqatpgvd
     5461 sisgdlqpdt gepfemisss vnvlgqqtlt fevpsghqla dscsdeepae ilefppddsq
     5521 eattpladeg rapkdkpesk ksgllwfwlp nigfsssvde tgvdskndvq rsapiqtqpe
     5581 arpeaelpkk qekagwfrfp klgfsssptk kskstedgae leeqklqeet itffdaresf
     5641 speekeegel igpvgtglds rvmvtsaart elilpeqdrk addeskgsgl gpneg
//
LOCUS       XP_011534691             802 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase TRIM9 isoform X1 [Homo sapiens].
ACCESSION   XP_011534691
VERSION     XP_011534691.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536389.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..802
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..802
                     /product="E3 ubiquitin-protein ligase TRIM9 isoform X1"
                     /calculated_mol_wt=89631
     Region          5..49
                     /region_name="RING_Ubox"
                     /note="RING finger (Really Interesting New Gene) domain
                     and U-box domain superfamily; cl17238"
                     /db_xref="CDD:473075"
     Region          166..212
                     /region_name="Bbox1_TRIM9_C-I"
                     /note="B-box-type 1 zinc finger found in tripartite
                     motif-containing protein 9 (TRIM9) and similar proteins;
                     cd19843"
                     /db_xref="CDD:380901"
     Region          223..271
                     /region_name="Bbox2_TRIM9_C-I"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing protein 9 (TRIM9) and similar proteins;
                     cd19826"
                     /db_xref="CDD:380884"
     Region          273..399
                     /region_name="BBC"
                     /note="B-Box C-terminal domain; smart00502"
                     /db_xref="CDD:128778"
     Region          449..528
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(517..518,520..521)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          616..773
                     /region_name="SPRY_PRY_TRIM67_9"
                     /note="PRY/SPRY domain in tripartite motif-containing
                     proteins, TRIM9 and TRIM67; cd12889"
                     /db_xref="CDD:293947"
     CDS             1..802
                     /gene="TRIM9"
                     /gene_synonym="RNF91; SPRING"
                     /coded_by="XM_011536389.3:167..2575"
                     /db_xref="GeneID:114088"
                     /db_xref="HGNC:HGNC:16288"
                     /db_xref="MIM:606555"
ORIGIN      
        1 meemeeelkc pvcgsfyrep iilpcshnlc qacarnilvq tpesespqsh raagsgvsdy
       61 dyldldkmsl yseadsgygs yggfasaptt pcqkspngvr vfppampppa thlspalapv
      121 prnscitcpq chrslilddr glrgfpknrv legvidryqq skaaalkcql cekapkeatv
      181 mceqcdvfyc dpcrlrchpp rgplakhrlv ppaqgrvsrr lsprkvstct dhelenhsmy
      241 cvqckmpvcy qcleegkhss hevkalgamw klhksqlsqa lnglsdrake akeflvqlrn
      301 mvqqiqensv efeaclvaqc dalidalnrr kaqllarvnk ehehklkvvr dqishctvkl
      361 rqttglmeyc levikendps gflqisdali rrvhltedqw gkgtltprmt tdfdlsldns
      421 pllqsihqld fvqvkvpatp ilqleeccth nnsatlswkq pplstvpadg yilelddgng
      481 gqfrevyvgk etmctvdglh fnstynarvk afnktgvspy sktlvlqtse dtdseeqtlp
      541 fpvpserlpl rrmspfsstl nlqpsfpgrs yfdfrssphq lslhsslqsl napgcnfetq
      601 sapysqlvdi kkllavawfa fdpgsahsdi ilsndnltvt cssyddrvvl gktgfskgih
      661 yweltvdryd nhpdpafgva rmdvmkdvml gkddkawamy vdnnrswfmh nnshtnrteg
      721 gitkgatigv lldlnrknlt ffindeqqgp iafdnveglf fpavslnrnv qvstlplrln
      781 sccwlpvqrl pravqsnrre gs
//
LOCUS       XP_016876437             688 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase TRIM9 isoform X2 [Homo sapiens].
ACCESSION   XP_016876437
VERSION     XP_016876437.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020948.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..688
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..688
                     /product="E3 ubiquitin-protein ligase TRIM9 isoform X2"
                     /calculated_mol_wt=76412
     Region          5..49
                     /region_name="RING_Ubox"
                     /note="RING finger (Really Interesting New Gene) domain
                     and U-box domain superfamily; cl17238"
                     /db_xref="CDD:473075"
     Region          166..212
                     /region_name="Bbox1_TRIM9_C-I"
                     /note="B-box-type 1 zinc finger found in tripartite
                     motif-containing protein 9 (TRIM9) and similar proteins;
                     cd19843"
                     /db_xref="CDD:380901"
     Region          223..271
                     /region_name="Bbox2_TRIM9_C-I"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing protein 9 (TRIM9) and similar proteins;
                     cd19826"
                     /db_xref="CDD:380884"
     Region          273..399
                     /region_name="BBC"
                     /note="B-Box C-terminal domain; smart00502"
                     /db_xref="CDD:128778"
     Region          449..528
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(517..518,520..521)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          525..678
                     /region_name="SPRY_PRY_TRIM67_9"
                     /note="PRY/SPRY domain in tripartite motif-containing
                     proteins, TRIM9 and TRIM67; cd12889"
                     /db_xref="CDD:293947"
     CDS             1..688
                     /gene="TRIM9"
                     /gene_synonym="RNF91; SPRING"
                     /coded_by="XM_017020948.2:167..2233"
                     /db_xref="GeneID:114088"
                     /db_xref="HGNC:HGNC:16288"
                     /db_xref="MIM:606555"
ORIGIN      
        1 meemeeelkc pvcgsfyrep iilpcshnlc qacarnilvq tpesespqsh raagsgvsdy
       61 dyldldkmsl yseadsgygs yggfasaptt pcqkspngvr vfppampppa thlspalapv
      121 prnscitcpq chrslilddr glrgfpknrv legvidryqq skaaalkcql cekapkeatv
      181 mceqcdvfyc dpcrlrchpp rgplakhrlv ppaqgrvsrr lsprkvstct dhelenhsmy
      241 cvqckmpvcy qcleegkhss hevkalgamw klhksqlsqa lnglsdrake akeflvqlrn
      301 mvqqiqensv efeaclvaqc dalidalnrr kaqllarvnk ehehklkvvr dqishctvkl
      361 rqttglmeyc levikendps gflqisdali rrvhltedqw gkgtltprmt tdfdlsldns
      421 pllqsihqld fvqvkvpatp ilqleeccth nnsatlswkq pplstvpadg yilelddgng
      481 gqfrevyvgk etmctvdglh fnstynarvk afnktgvspy sktlvlqtse vawfafdpgs
      541 ahsdiilsnd nltvtcssyd drvvlgktgf skgihywelt vdrydnhpdp afgvarmdvm
      601 kdvmlgkddk awaiteggit kgatigvlld lnrknltffi ndeqqgpiaf dnveglffpa
      661 vslnrnvqvt lhtglpvpdf yssrasia
//
LOCUS       XP_047286861             607 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase TRIM9 isoform X3 [Homo sapiens].
ACCESSION   XP_047286861
VERSION     XP_047286861.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430905.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..607
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..607
                     /product="E3 ubiquitin-protein ligase TRIM9 isoform X3"
                     /calculated_mol_wt=67475
     Region          5..49
                     /region_name="RING_Ubox"
                     /note="RING finger (Really Interesting New Gene) domain
                     and U-box domain superfamily; cl17238"
                     /db_xref="CDD:473075"
     Region          166..212
                     /region_name="Bbox_SF"
                     /note="B-box-type zinc finger superfamily; cl00034"
                     /db_xref="CDD:469587"
     Region          223..271
                     /region_name="Bbox_SF"
                     /note="B-box-type zinc finger superfamily; cl00034"
                     /db_xref="CDD:469587"
     Region          273..399
                     /region_name="BBC"
                     /note="B-Box C-terminal domain; smart00502"
                     /db_xref="CDD:128778"
     Region          453..532
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(521..522,524..525)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     CDS             1..607
                     /gene="TRIM9"
                     /gene_synonym="RNF91; SPRING"
                     /coded_by="XM_047430905.1:167..1990"
                     /db_xref="GeneID:114088"
                     /db_xref="HGNC:HGNC:16288"
                     /db_xref="MIM:606555"
ORIGIN      
        1 meemeeelkc pvcgsfyrep iilpcshnlc qacarnilvq tpesespqsh raagsgvsdy
       61 dyldldkmsl yseadsgygs yggfasaptt pcqkspngvr vfppampppa thlspalapv
      121 prnscitcpq chrslilddr glrgfpknrv legvidryqq skaaalkcql cekapkeatv
      181 mceqcdvfyc dpcrlrchpp rgplakhrlv ppaqgrvsrr lsprkvstct dhelenhsmy
      241 cvqckmpvcy qcleegkhss hevkalgamw klhksqlsqa lnglsdrake akeflvqlrn
      301 mvqqiqensv efeaclvaqc dalidalnrr kaqllarvnk ehehklkvvr dqishctvkl
      361 rqttglmeyc levikendps gflqisdali rrvhltedqw gkgtltprmt tdfdlsldns
      421 pllqsihqld fvqvkasspv patpilqlee ccthnnsatl swkqpplstv padgyileld
      481 dgnggqfrev yvgketmctv dglhfnstyn arvkafnktg vspysktlvl qtsedtdsee
      541 qtlpfpvpse rlplrrmspf sstlnlqpsf pgrsyfdfrs sphqlslhss lqslnapgel
      601 sssdlsp
//
LOCUS       XP_047286862             156 aa            linear   PRI 05-AUG-2025
DEFINITION  CKLF-like MARVEL transmembrane domain-containing protein 5 isoform
            X1 [Homo sapiens].
ACCESSION   XP_047286862
VERSION     XP_047286862.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430906.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..156
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..156
                     /product="CKLF-like MARVEL transmembrane domain-containing
                     protein 5 isoform X1"
                     /calculated_mol_wt=17313
     Region          29..139
                     /region_name="MARVEL"
                     /note="Membrane-associating domain; pfam01284"
                     /db_xref="CDD:366555"
     CDS             1..156
                     /gene="CMTM5"
                     /gene_synonym="CKLFSF5"
                     /coded_by="XM_047430906.1:99..569"
                     /db_xref="GeneID:116173"
                     /db_xref="HGNC:HGNC:19176"
                     /db_xref="MIM:607888"
ORIGIN      
        1 mlsardrrdr hpeegvvael qgfavdkafl tshkgillet elaltliifi cftasisaym
       61 aaalleffit laflflyatq yyqrfdrinw pcldflrcvs aiiiflvvsf aavtsrdgaa
      121 iaafvfgiil vsifaydafk iyrtemapga sqgdqq
//
LOCUS       XP_047286863             156 aa            linear   PRI 05-AUG-2025
DEFINITION  CKLF-like MARVEL transmembrane domain-containing protein 5 isoform
            X1 [Homo sapiens].
ACCESSION   XP_047286863
VERSION     XP_047286863.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430907.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..156
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..156
                     /product="CKLF-like MARVEL transmembrane domain-containing
                     protein 5 isoform X1"
                     /calculated_mol_wt=17313
     Region          29..139
                     /region_name="MARVEL"
                     /note="Membrane-associating domain; pfam01284"
                     /db_xref="CDD:366555"
     CDS             1..156
                     /gene="CMTM5"
                     /gene_synonym="CKLFSF5"
                     /coded_by="XM_047430907.1:352..822"
                     /db_xref="GeneID:116173"
                     /db_xref="HGNC:HGNC:19176"
                     /db_xref="MIM:607888"
ORIGIN      
        1 mlsardrrdr hpeegvvael qgfavdkafl tshkgillet elaltliifi cftasisaym
       61 aaalleffit laflflyatq yyqrfdrinw pcldflrcvs aiiiflvvsf aavtsrdgaa
      121 iaafvfgiil vsifaydafk iyrtemapga sqgdqq
//
LOCUS       XP_006720082            1363 aa            linear   PRI 05-AUG-2025
DEFINITION  ATP-dependent RNA helicase TDRD9 isoform X1 [Homo sapiens].
ACCESSION   XP_006720082
VERSION     XP_006720082.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720019.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1363
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1363
                     /product="ATP-dependent RNA helicase TDRD9 isoform X1"
                     /calculated_mol_wt=153211
     Region          130..>716
                     /region_name="HrpA"
                     /note="HrpA-like RNA helicase [Translation, ribosomal
                     structure and biogenesis]; COG1643"
                     /db_xref="CDD:441249"
     Region          132..315
                     /region_name="DEXHc_TDRD9"
                     /note="DEXH-box helicase domain of tudor domain containing
                     9; cd17988"
                     /db_xref="CDD:350746"
     Site            order(132,157..163,198,254..255)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:350746"
     Region          905..1005
                     /region_name="Tudor_TDRD9"
                     /note="Tudor domain found in Tudor domain-containing
                     protein 9 (TDRD9) and similar proteins; cd20431"
                     /db_xref="CDD:410502"
     Site            order(955,964,980,983,985)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410502"
     CDS             1..1363
                     /gene="TDRD9"
                     /gene_synonym="C14orf75; HIG-1; HLS; NET54; SPGF30; SPNE"
                     /coded_by="XM_006720019.4:55..4146"
                     /db_xref="GeneID:122402"
                     /db_xref="HGNC:HGNC:20122"
                     /db_xref="MIM:617963"
ORIGIN      
        1 mlrkltieqi ndwftigktv tnvellgapp afpagaaree vqrqdvapga gpaaqapala
       61 qaparpaaaf erslsqrsse veyinkyrql eaqeldvcrs vqptsgpgpr pslaklssvt
      121 cipgttykyp dlpisrykee vvsliesnsv viihgatgsg kstqlpqyil dhyvqrsayc
      181 sivvtqprki gassiarwis kerawtlggv vgyqvgleki atedtrliym ttgvllqkiv
      241 sakslmefth iiidevhert eemdflllvv rkllrtnsrf vkvvlmsati sckefadyfa
      301 vpvqnkmnpa yifevegkph sveeyylndl ehihhsklsp hlleepvitk diyevavsli
      361 qmfddldmke sgnkawsgaq fvlerssvlv flpglgeiny mhelltslvh krlqvyplhs
      421 svaleeqnnv flspvpgyrk iilstniaes svtvpdvkyv idfcltrtlv cdedtnyqsl
      481 rlswasktsc nqrkgragrv srgycyrlvh kdfwdnsipd hvvpemlrcp lgstilkvkl
      541 ldmgeprall atalsppgls diertilllk evgalavsgq redenphdge ltflgrvlaq
      601 lpvnqqlgkl ivlghvfgcl decliiaaal slknffampf rqhldgyrnk vnfsgssksd
      661 cialveafkt wkacrqtgel rypkdelnwg rlnyiqikri revaelyeel ktrisqfnmh
      721 vdsrrpvmdq eyiykqrfil qvvlagafyp nyftfgqpde emavrelagk dpkttvvlkh
      781 ippygflyyk qlqslfrqcg qvksivfdga kafvefsrnp terfktlpav ymaikmsqlk
      841 vslelsvhsa eeiegkvqgm nvsklrntrv nvdfqkqtvd pmqvsfntsd rsqtvtdlll
      901 tidvtevvev ghfwgyride nnseilkklt aeinqltlvp lpthphpdlv clapfadfdk
      961 qryfraqvly vsgnsaevff vdygnkshvd lhllmeipcq flelpfqale fkickmrpsa
     1021 kslvcgkhws dgasqwfasl vsgctllvkv fsvvhsvlhv dvyqysgvqd ainirdvliq
     1081 qgyaeltees yeskqshevl kglfsksven mtdgsvpfpm kddekyliri llesfstnkl
     1141 gtpnckaelh gpfnpyelkc hsltriskfr cvwiekesin sviisdaped lhqrmlvaas
     1201 lsinatgstm llretslmph ipglpallsm lfapvielri dqngkyytgv lcglgwnpat
     1261 gasilpehdm elafdvqfsv edvvevnilr aainklvcdg pngckclgpe rvaqlqdiar
     1321 qkllglfcqs kprekivpkw hekpyewnqc llcdvpaksq tpg
//
LOCUS       XP_006720083            1355 aa            linear   PRI 05-AUG-2025
DEFINITION  ATP-dependent RNA helicase TDRD9 isoform X2 [Homo sapiens].
ACCESSION   XP_006720083
VERSION     XP_006720083.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720020.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1355
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1355
                     /product="ATP-dependent RNA helicase TDRD9 isoform X2"
                     /calculated_mol_wt=152241
     Region          130..>689
                     /region_name="HrpA"
                     /note="HrpA-like RNA helicase [Translation, ribosomal
                     structure and biogenesis]; COG1643"
                     /db_xref="CDD:441249"
     Region          878..978
                     /region_name="Tudor_TDRD9"
                     /note="Tudor domain found in Tudor domain-containing
                     protein 9 (TDRD9) and similar proteins; cd20431"
                     /db_xref="CDD:410502"
     Site            order(928,937,953,956,958)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410502"
     CDS             1..1355
                     /gene="TDRD9"
                     /gene_synonym="C14orf75; HIG-1; HLS; NET54; SPGF30; SPNE"
                     /coded_by="XM_006720020.4:55..4122"
                     /db_xref="GeneID:122402"
                     /db_xref="HGNC:HGNC:20122"
                     /db_xref="MIM:617963"
ORIGIN      
        1 mlrkltieqi ndwftigktv tnvellgapp afpagaaree vqrqdvapga gpaaqapala
       61 qaparpaaaf erslsqrsse veyinkyrql eaqeldvcrs vqptsgpgpr pslaklssvt
      121 cipgttykyp dlpisrykee vvsliesnsv viihgatgsg kstqlpqyil dhyvqrsayc
      181 sivvtqprki gassiarwis kerawtlggv vgyqvgleki atedtrliym ttgvllqkiv
      241 sakslmefth iiidevvlms atisckefad yfavpvqnkm npayifeveg kphsveeyyl
      301 ndlehihhsk lsphlleepv itkdiyevav sliqmfddld mkesgnkaws gaqfvlerss
      361 vlvflpglge inymhellts lvhkrlqvyp lhssvaleeq nnvflspvpg yrkiilstni
      421 aessvtvpdv kyvidfcltr tlvcdedtny qslrlswask tscnqrkgra grvsrgycyr
      481 lvhkdfwdns ipdhvvpeml rcplgstilk vklldmgepr allatalspp glsdiertil
      541 llkevgalav sgqredenph dgeltflgrv laqlpvnqql gklivlghvf gcldecliia
      601 aalslknffa mpfrqhldgy rnkvnfsgss ksdcialvea fktwkacrqt gelrypkdel
      661 nwgrlnyiqi krirevaely eelktrisqf nmhvdsrrpv mdqeyiykqr filqvvlaga
      721 fypnyftfgq pdeemavrel agkdpkttvv lkhippygfl yykqlqslfr qcgqvksivf
      781 dgakafvefs rnpterfktl pavymaikms qlkvslelsv hsaeeiegkv qgmnvsklrn
      841 trvnvdfqkq tvdpmqvsfn tsdrsqtvtd llltidvtev vevghfwgyr idennseilk
      901 kltaeinqlt lvplpthphp dlvclapfad fdkqryfraq vlyvsgnsae vffvdygnks
      961 hvdlhllmei pcqflelpfq alefkickmr psakslvcgk hwsdgasqwf aslvsgctll
     1021 vkvfsvvhsv lhvdvyqysg vqdainirdv liqqgyaelt eesyeskqsh evlkglfsks
     1081 venmtdgsvp fpmkddekyl irillesfst nklgtpncka elhgpfnpye lkchsltris
     1141 kfrcvwieke sinsviisda pedlhqrmlv aaslsinatg stmllretsl mphipglpal
     1201 lsmlfapvie lridqngkyy tgvlcglgwn patgasilpe hdmelafdvq fsvedvvevn
     1261 ilraainklv cdgpngckcl gpervaqlqd iarqkllglf cqskprekiv pkwhekpyew
     1321 nqvdpklvme qadressrgk ntflyqlhkl vvlgt
//
LOCUS       XP_011534699            1347 aa            linear   PRI 05-AUG-2025
DEFINITION  ATP-dependent RNA helicase TDRD9 isoform X3 [Homo sapiens].
ACCESSION   XP_011534699
VERSION     XP_011534699.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536397.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1347
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1347
                     /product="ATP-dependent RNA helicase TDRD9 isoform X3"
                     /calculated_mol_wt=151475
     Region          130..>681
                     /region_name="HrpA"
                     /note="HrpA-like RNA helicase [Translation, ribosomal
                     structure and biogenesis]; COG1643"
                     /db_xref="CDD:441249"
     Region          132..315
                     /region_name="DEXHc_TDRD9"
                     /note="DEXH-box helicase domain of tudor domain containing
                     9; cd17988"
                     /db_xref="CDD:350746"
     Site            order(132,157..163,198,254..255)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:350746"
     Region          870..970
                     /region_name="Tudor_TDRD9"
                     /note="Tudor domain found in Tudor domain-containing
                     protein 9 (TDRD9) and similar proteins; cd20431"
                     /db_xref="CDD:410502"
     Site            order(920,929,945,948,950)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410502"
     CDS             1..1347
                     /gene="TDRD9"
                     /gene_synonym="C14orf75; HIG-1; HLS; NET54; SPGF30; SPNE"
                     /coded_by="XM_011536397.3:55..4098"
                     /db_xref="GeneID:122402"
                     /db_xref="HGNC:HGNC:20122"
                     /db_xref="MIM:617963"
ORIGIN      
        1 mlrkltieqi ndwftigktv tnvellgapp afpagaaree vqrqdvapga gpaaqapala
       61 qaparpaaaf erslsqrsse veyinkyrql eaqeldvcrs vqptsgpgpr pslaklssvt
      121 cipgttykyp dlpisrykee vvsliesnsv viihgatgsg kstqlpqyil dhyvqrsayc
      181 sivvtqprki gassiarwis kerawtlggv vgyqvgleki atedtrliym ttgvllqkiv
      241 sakslmefth iiidevhert eemdflllvv rkllrtnsrf vkvvlmsati sckefadyfa
      301 vpvqnkmnpa yifevegkph sveeyylndl ehihhsklsp hlleepvitk diyevavsli
      361 qmfddldmke sgnkawsgaq fvlerssvlv flpglgeiny mhelltslvh krlqvyplhs
      421 svaleeqnnv flspvpgyrk iilstniaes svtvpdvkyg ragrvsrgyc yrlvhkdfwd
      481 nsipdhvvpe mlrcplgsti lkvklldmge prallatals ppglsdiert illlkevgal
      541 avsgqreden phdgeltflg rvlaqlpvnq qlgklivlgh vfgcldecli iaaalslknf
      601 fampfrqhld gyrnkvnfsg ssksdcialv eafktwkacr qtgelrypkd elnwgrlnyi
      661 qikrirevae lyeelktris qfnmhvdsrr pvmdqeyiyk qrfilqvvla gafypnyftf
      721 gqpdeemavr elagkdpktt vvlkhippyg flyykqlqsl frqcgqvksi vfdgakafve
      781 fsrnpterfk tlpavymaik msqlkvslel svhsaeeieg kvqgmnvskl rntrvnvdfq
      841 kqtvdpmqvs fntsdrsqtv tdllltidvt evvevghfwg yridennsei lkkltaeinq
      901 ltlvplpthp hpdlvclapf adfdkqryfr aqvlyvsgns aevffvdygn kshvdlhllm
      961 eipcqflelp fqalefkick mrpsakslvc gkhwsdgasq wfaslvsgct llvkvfsvvh
     1021 svlhvdvyqy sgvqdainir dvliqqgyae lteesyeskq shevlkglfs ksvenmtdgs
     1081 vpfpmkddek ylirillesf stnklgtpnc kaelhgpfnp yelkchsltr iskfrcvwie
     1141 kesinsviis dapedlhqrm lvaaslsina tgstmllret slmphipglp allsmlfapv
     1201 ielridqngk yytgvlcglg wnpatgasil pehdmelafd vqfsvedvve vnilraaink
     1261 lvcdgpngck clgpervaql qdiarqkllg lfcqskprek ivpkwhekpy ewnqvdpklv
     1321 meqadressr gkntflyqlh klvvlgt
//
LOCUS       XP_011534700            1344 aa            linear   PRI 05-AUG-2025
DEFINITION  ATP-dependent RNA helicase TDRD9 isoform X4 [Homo sapiens].
ACCESSION   XP_011534700
VERSION     XP_011534700.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536398.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1344
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1344
                     /product="ATP-dependent RNA helicase TDRD9 isoform X4"
                     /calculated_mol_wt=152009
     Region          92..>678
                     /region_name="HrpA"
                     /note="HrpA-like RNA helicase [Translation, ribosomal
                     structure and biogenesis]; COG1643"
                     /db_xref="CDD:441249"
     Region          94..277
                     /region_name="DEXHc_TDRD9"
                     /note="DEXH-box helicase domain of tudor domain containing
                     9; cd17988"
                     /db_xref="CDD:350746"
     Site            order(94,119..125,160,216..217)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:350746"
     Region          867..967
                     /region_name="Tudor_TDRD9"
                     /note="Tudor domain found in Tudor domain-containing
                     protein 9 (TDRD9) and similar proteins; cd20431"
                     /db_xref="CDD:410502"
     Site            order(917,926,942,945,947)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410502"
     CDS             1..1344
                     /gene="TDRD9"
                     /gene_synonym="C14orf75; HIG-1; HLS; NET54; SPGF30; SPNE"
                     /coded_by="XM_011536398.4:18..4052"
                     /db_xref="GeneID:122402"
                     /db_xref="HGNC:HGNC:20122"
                     /db_xref="MIM:617963"
ORIGIN      
        1 mrdlkyhcse gphgkhengi waarskdwip ldsrslsqrs seveyinkyr qleaqeldvc
       61 rsvqptsgpg prpslaklss vtcipgttyk ypdlpisryk eevvsliesn svviihgatg
      121 sgkstqlpqy ildhyvqrsa ycsivvtqpr kigassiarw iskerawtlg gvvgyqvgle
      181 kiatedtrli ymttgvllqk ivsakslmef thiiidevhe rteemdflll vvrkllrtns
      241 rfvkvvlmsa tisckefady favpvqnkmn payifevegk phsveeyyln dlehihhskl
      301 sphlleepvi tkdiyevavs liqmfddldm kesgnkawsg aqfvlerssv lvflpglgei
      361 nymhelltsl vhkrlqvypl hssvaleeqn nvflspvpgy rkiilstnia essvtvpdvk
      421 yvidfcltrt lvcdedtnyq slrlswaskt scnqrkgrag rvsrgycyrl vhkdfwdnsi
      481 pdhvvpemlr cplgstilkv klldmgepra llatalsppg lsdiertill lkevgalavs
      541 gqredenphd geltflgrvl aqlpvnqqlg klivlghvfg cldecliiaa alslknffam
      601 pfrqhldgyr nkvnfsgssk sdcialveaf ktwkacrqtg elrypkdeln wgrlnyiqik
      661 rirevaelye elktrisqfn mhvdsrrpvm dqeyiykqrf ilqvvlagaf ypnyftfgqp
      721 deemavrela gkdpkttvvl khippygfly ykqlqslfrq cgqvksivfd gakafvefsr
      781 npterfktlp avymaikmsq lkvslelsvh saeeiegkvq gmnvsklrnt rvnvdfqkqt
      841 vdpmqvsfnt sdrsqtvtdl lltidvtevv evghfwgyri dennseilkk ltaeinqltl
      901 vplpthphpd lvclapfadf dkqryfraqv lyvsgnsaev ffvdygnksh vdlhllmeip
      961 cqflelpfqa lefkickmrp sakslvcgkh wsdgasqwfa slvsgctllv kvfsvvhsvl
     1021 hvdvyqysgv qdainirdvl iqqgyaelte esyeskqshe vlkglfsksv enmtdgsvpf
     1081 pmkddekyli rillesfstn klgtpnckae lhgpfnpyel kchsltrisk frcvwiekes
     1141 insviisdap edlhqrmlva aslsinatgs tmllretslm phipglpall smlfapviel
     1201 ridqngkyyt gvlcglgwnp atgasilpeh dmelafdvqf svedvvevni lraainklvc
     1261 dgpngckclg pervaqlqdi arqkllglfc qskprekivp kwhekpyewn qvdpklvmeq
     1321 adressrgkn tflyqlhklv vlgt
//
LOCUS       XP_005267366            1330 aa            linear   PRI 05-AUG-2025
DEFINITION  ATP-dependent RNA helicase TDRD9 isoform X5 [Homo sapiens].
ACCESSION   XP_005267366
VERSION     XP_005267366.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267309.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1330
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1330
                     /product="ATP-dependent RNA helicase TDRD9 isoform X5"
                     /calculated_mol_wt=149697
     Region          130..>716
                     /region_name="HrpA"
                     /note="HrpA-like RNA helicase [Translation, ribosomal
                     structure and biogenesis]; COG1643"
                     /db_xref="CDD:441249"
     Region          132..315
                     /region_name="DEXHc_TDRD9"
                     /note="DEXH-box helicase domain of tudor domain containing
                     9; cd17988"
                     /db_xref="CDD:350746"
     Site            order(132,157..163,198,254..255)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:350746"
     Region          905..1005
                     /region_name="Tudor_TDRD9"
                     /note="Tudor domain found in Tudor domain-containing
                     protein 9 (TDRD9) and similar proteins; cd20431"
                     /db_xref="CDD:410502"
     Site            order(955,964,980,983,985)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410502"
     CDS             1..1330
                     /gene="TDRD9"
                     /gene_synonym="C14orf75; HIG-1; HLS; NET54; SPGF30; SPNE"
                     /coded_by="XM_005267309.5:55..4047"
                     /db_xref="GeneID:122402"
                     /db_xref="HGNC:HGNC:20122"
                     /db_xref="MIM:617963"
ORIGIN      
        1 mlrkltieqi ndwftigktv tnvellgapp afpagaaree vqrqdvapga gpaaqapala
       61 qaparpaaaf erslsqrsse veyinkyrql eaqeldvcrs vqptsgpgpr pslaklssvt
      121 cipgttykyp dlpisrykee vvsliesnsv viihgatgsg kstqlpqyil dhyvqrsayc
      181 sivvtqprki gassiarwis kerawtlggv vgyqvgleki atedtrliym ttgvllqkiv
      241 sakslmefth iiidevhert eemdflllvv rkllrtnsrf vkvvlmsati sckefadyfa
      301 vpvqnkmnpa yifevegkph sveeyylndl ehihhsklsp hlleepvitk diyevavsli
      361 qmfddldmke sgnkawsgaq fvlerssvlv flpglgeiny mhelltslvh krlqvyplhs
      421 svaleeqnnv flspvpgyrk iilstniaes svtvpdvkyv idfcltrtlv cdedtnyqsl
      481 rlswasktsc nqrkgragrv srgycyrlvh kdfwdnsipd hvvpemlrcp lgstilkvkl
      541 ldmgeprall atalsppgls diertilllk evgalavsgq redenphdge ltflgrvlaq
      601 lpvnqqlgkl ivlghvfgcl decliiaaal slknffampf rqhldgyrnk vnfsgssksd
      661 cialveafkt wkacrqtgel rypkdelnwg rlnyiqikri revaelyeel ktrisqfnmh
      721 vdsrrpvmdq eyiykqrfil qvvlagafyp nyftfgqpde emavrelagk dpkttvvlkh
      781 ippygflyyk qlqslfrqcg qvksivfdga kafvefsrnp terfktlpav ymaikmsqlk
      841 vslelsvhsa eeiegkvqgm nvsklrntrv nvdfqkqtvd pmqvsfntsd rsqtvtdlll
      901 tidvtevvev ghfwgyride nnseilkklt aeinqltlvp lpthphpdlv clapfadfdk
      961 qryfraqvly vsgnsaevff vdygnkshvd lhllmeipcq flelpfqale fkickmrpsa
     1021 kslvcgkhws dgasqwfasl vsgctllvkv fsvvhsvlhv dvyqysgvqd ainirdvliq
     1081 qgyaeltees yeskaelhgp fnpyelkchs ltriskfrcv wiekesinsv iisdapedlh
     1141 qrmlvaasls inatgstmll retslmphip glpallsmlf apvielridq ngkyytgvlc
     1201 glgwnpatga silpehdmel afdvqfsved vvevnilraa inklvcdgpn gckclgperv
     1261 aqlqdiarqk llglfcqskp rekivpkwhe kpyewnqvdp klvmeqadre ssrgkntfly
     1321 qlhklvvlgt
//
LOCUS       XP_047286865            1303 aa            linear   PRI 05-AUG-2025
DEFINITION  ATP-dependent RNA helicase TDRD9 isoform X6 [Homo sapiens].
ACCESSION   XP_047286865
VERSION     XP_047286865.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430909.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1303
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1303
                     /product="ATP-dependent RNA helicase TDRD9 isoform X6"
                     /calculated_mol_wt=146385
     Region          130..>689
                     /region_name="HrpA"
                     /note="HrpA-like RNA helicase [Translation, ribosomal
                     structure and biogenesis]; COG1643"
                     /db_xref="CDD:441249"
     Region          878..978
                     /region_name="Tudor_TDRD9"
                     /note="Tudor domain found in Tudor domain-containing
                     protein 9 (TDRD9) and similar proteins; cd20431"
                     /db_xref="CDD:410502"
     Site            order(928,937,953,956,958)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410502"
     CDS             1..1303
                     /gene="TDRD9"
                     /gene_synonym="C14orf75; HIG-1; HLS; NET54; SPGF30; SPNE"
                     /coded_by="XM_047430909.1:55..3966"
                     /db_xref="GeneID:122402"
                     /db_xref="HGNC:HGNC:20122"
                     /db_xref="MIM:617963"
ORIGIN      
        1 mlrkltieqi ndwftigktv tnvellgapp afpagaaree vqrqdvapga gpaaqapala
       61 qaparpaaaf erslsqrsse veyinkyrql eaqeldvcrs vqptsgpgpr pslaklssvt
      121 cipgttykyp dlpisrykee vvsliesnsv viihgatgsg kstqlpqyil dhyvqrsayc
      181 sivvtqprki gassiarwis kerawtlggv vgyqvgleki atedtrliym ttgvllqkiv
      241 sakslmefth iiidevvlms atisckefad yfavpvqnkm npayifeveg kphsveeyyl
      301 ndlehihhsk lsphlleepv itkdiyevav sliqmfddld mkesgnkaws gaqfvlerss
      361 vlvflpglge inymhellts lvhkrlqvyp lhssvaleeq nnvflspvpg yrkiilstni
      421 aessvtvpdv kyvidfcltr tlvcdedtny qslrlswask tscnqrkgra grvsrgycyr
      481 lvhkdfwdns ipdhvvpeml rcplgstilk vklldmgepr allatalspp glsdiertil
      541 llkevgalav sgqredenph dgeltflgrv laqlpvnqql gklivlghvf gcldecliia
      601 aalslknffa mpfrqhldgy rnkvnfsgss ksdcialvea fktwkacrqt gelrypkdel
      661 nwgrlnyiqi krirevaely eelktrisqf nmhvdsrrpv mdqeyiykqr filqvvlaga
      721 fypnyftfgq pdeemavrel agkdpkttvv lkhippygfl yykqlqslfr qcgqvksivf
      781 dgakafvefs rnpterfktl pavymaikms qlkvslelsv hsaeeiegkv qgmnvsklrn
      841 trvnvdfqkq tvdpmqvsfn tsdrsqtvtd llltidvtev vevghfwgyr idennseilk
      901 kltaeinqlt lvplpthphp dlvclapfad fdkqryfraq vlyvsgnsae vffvdygnks
      961 hvdlhllmei pcqflelpfq alefkickmr psakslvcgk hwsdgasqwf aslvsgctll
     1021 vkvfsvvhsv lhvdvyqysg vqdainirdv liqqgyaelt eesyeskael hgpfnpyelk
     1081 chsltriskf rcvwiekesi nsviisdape dlhqrmlvaa slsinatgst mllretslmp
     1141 hipglpalls mlfapvielr idqngkyytg vlcglgwnpa tgasilpehd melafdvqfs
     1201 vedvvevnil raainklvcd gpngckclgp ervaqlqdia rqkllglfcq skprekivpk
     1261 whekpyewnq vdpklvmeqa dressrgknt flyqlhklvv lgt
//
LOCUS       XP_011534702            1295 aa            linear   PRI 05-AUG-2025
DEFINITION  ATP-dependent RNA helicase TDRD9 isoform X7 [Homo sapiens].
ACCESSION   XP_011534702
VERSION     XP_011534702.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536400.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1295
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1295
                     /product="ATP-dependent RNA helicase TDRD9 isoform X7"
                     /calculated_mol_wt=145588
     Region          130..>629
                     /region_name="HrpA"
                     /note="HrpA-like RNA helicase [Translation, ribosomal
                     structure and biogenesis]; COG1643"
                     /db_xref="CDD:441249"
     Region          132..315
                     /region_name="DEXHc_TDRD9"
                     /note="DEXH-box helicase domain of tudor domain containing
                     9; cd17988"
                     /db_xref="CDD:350746"
     Site            order(132,157..163,198,254..255)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:350746"
     Region          818..918
                     /region_name="Tudor_TDRD9"
                     /note="Tudor domain found in Tudor domain-containing
                     protein 9 (TDRD9) and similar proteins; cd20431"
                     /db_xref="CDD:410502"
     Site            order(868,877,893,896,898)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410502"
     CDS             1..1295
                     /gene="TDRD9"
                     /gene_synonym="C14orf75; HIG-1; HLS; NET54; SPGF30; SPNE"
                     /coded_by="XM_011536400.3:55..3942"
                     /db_xref="GeneID:122402"
                     /db_xref="HGNC:HGNC:20122"
                     /db_xref="MIM:617963"
ORIGIN      
        1 mlrkltieqi ndwftigktv tnvellgapp afpagaaree vqrqdvapga gpaaqapala
       61 qaparpaaaf erslsqrsse veyinkyrql eaqeldvcrs vqptsgpgpr pslaklssvt
      121 cipgttykyp dlpisrykee vvsliesnsv viihgatgsg kstqlpqyil dhyvqrsayc
      181 sivvtqprki gassiarwis kerawtlggv vgyqvgleki atedtrliym ttgvllqkiv
      241 sakslmefth iiidevhert eemdflllvv rkllrtnsrf vkvvlmsati sckefadyfa
      301 vpvqnkmnpa yifevegkph sveeyylndl ehihhsklsp hlleepvitk diyevavsli
      361 qmfddldmke sgnkawsgaq fvlerssvlv flpglgeiny mhelltslvh krlqvyplhs
      421 svaleeqnnv flspvpgyrk rcplgstilk vklldmgepr allatalspp glsdiertil
      481 llkevgalav sgqredenph dgeltflgrv laqlpvnqql gklivlghvf gcldecliia
      541 aalslknffa mpfrqhldgy rnkvnfsgss ksdcialvea fktwkacrqt gelrypkdel
      601 nwgrlnyiqi krirevaely eelktrisqf nmhvdsrrpv mdqeyiykqr filqvvlaga
      661 fypnyftfgq pdeemavrel agkdpkttvv lkhippygfl yykqlqslfr qcgqvksivf
      721 dgakafvefs rnpterfktl pavymaikms qlkvslelsv hsaeeiegkv qgmnvsklrn
      781 trvnvdfqkq tvdpmqvsfn tsdrsqtvtd llltidvtev vevghfwgyr idennseilk
      841 kltaeinqlt lvplpthphp dlvclapfad fdkqryfraq vlyvsgnsae vffvdygnks
      901 hvdlhllmei pcqflelpfq alefkickmr psakslvcgk hwsdgasqwf aslvsgctll
      961 vkvfsvvhsv lhvdvyqysg vqdainirdv liqqgyaelt eesyeskqsh evlkglfsks
     1021 venmtdgsvp fpmkddekyl irillesfst nklgtpncka elhgpfnpye lkchsltris
     1081 kfrcvwieke sinsviisda pedlhqrmlv aaslsinatg stmllretsl mphipglpal
     1141 lsmlfapvie lridqngkyy tgvlcglgwn patgasilpe hdmelafdvq fsvedvvevn
     1201 ilraainklv cdgpngckcl gpervaqlqd iarqkllglf cqskprekiv pkwhekpyew
     1261 nqvdpklvme qadressrgk ntflyqlhkl vvlgt
//
LOCUS       XP_047286866            1295 aa            linear   PRI 05-AUG-2025
DEFINITION  ATP-dependent RNA helicase TDRD9 isoform X8 [Homo sapiens].
ACCESSION   XP_047286866
VERSION     XP_047286866.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430910.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1295
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1295
                     /product="ATP-dependent RNA helicase TDRD9 isoform X8"
                     /calculated_mol_wt=145620
     Region          130..>681
                     /region_name="HrpA"
                     /note="HrpA-like RNA helicase [Translation, ribosomal
                     structure and biogenesis]; COG1643"
                     /db_xref="CDD:441249"
     Region          132..315
                     /region_name="DEXHc_TDRD9"
                     /note="DEXH-box helicase domain of tudor domain containing
                     9; cd17988"
                     /db_xref="CDD:350746"
     Site            order(132,157..163,198,254..255)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:350746"
     Region          870..970
                     /region_name="Tudor_TDRD9"
                     /note="Tudor domain found in Tudor domain-containing
                     protein 9 (TDRD9) and similar proteins; cd20431"
                     /db_xref="CDD:410502"
     Site            order(920,929,945,948,950)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410502"
     CDS             1..1295
                     /gene="TDRD9"
                     /gene_synonym="C14orf75; HIG-1; HLS; NET54; SPGF30; SPNE"
                     /coded_by="XM_047430910.1:55..3942"
                     /db_xref="GeneID:122402"
                     /db_xref="HGNC:HGNC:20122"
                     /db_xref="MIM:617963"
ORIGIN      
        1 mlrkltieqi ndwftigktv tnvellgapp afpagaaree vqrqdvapga gpaaqapala
       61 qaparpaaaf erslsqrsse veyinkyrql eaqeldvcrs vqptsgpgpr pslaklssvt
      121 cipgttykyp dlpisrykee vvsliesnsv viihgatgsg kstqlpqyil dhyvqrsayc
      181 sivvtqprki gassiarwis kerawtlggv vgyqvgleki atedtrliym ttgvllqkiv
      241 sakslmefth iiidevhert eemdflllvv rkllrtnsrf vkvvlmsati sckefadyfa
      301 vpvqnkmnpa yifevegkph sveeyylndl ehihhsklsp hlleepvitk diyevavsli
      361 qmfddldmke sgnkawsgaq fvlerssvlv flpglgeiny mhelltslvh krlqvyplhs
      421 svaleeqnnv flspvpgyrk iilstniaes svtvpdvkyg ragrvsrgyc yrlvhkdfwd
      481 nsipdhvvpe mlrcplgsti lkvklldmge prallatals ppglsdiert illlkevgal
      541 avsgqreden phdgeltflg rvlaqlpvnq qlgklivlgh vfgcldecli iaaalslknf
      601 fampfrqhld gyrnkvnfsg ssksdcialv eafktwkacr qtgelrypkd elnwgrlnyi
      661 qikrirevae lyeelktris qfnmhvdsrr pvmdqeyiyk qrfilqvvla gafypnyftf
      721 gqpdeemavr elagkdpktt vvlkhippyg flyykqlqsl frqcgqvksi vfdgakafve
      781 fsrnpterfk tlpavymaik msqlkvslel svhsaeeieg kvqgmnvskl rntrvnvdfq
      841 kqtvdpmqvs fntsdrsqtv tdllltidvt evvevghfwg yridennsei lkkltaeinq
      901 ltlvplpthp hpdlvclapf adfdkqryfr aqvlyvsgns aevffvdygn kshvdlhllm
      961 eipcqflelp fqalefkick mrpsakslvc gkhwsdgasq wfaslvsgct llvkvfsvvh
     1021 svlhvdvyqy sgvqdainir dvliqqgyae lteesyeska elhgpfnpye lkchsltris
     1081 kfrcvwieke sinsviisda pedlhqrmlv aaslsinatg stmllretsl mphipglpal
     1141 lsmlfapvie lridqngkyy tgvlcglgwn patgasilpe hdmelafdvq fsvedvvevn
     1201 ilraainklv cdgpngckcl gpervaqlqd iarqkllglf cqskprekiv pkwhekpyew
     1261 nqvdpklvme qadressrgk ntflyqlhkl vvlgt
//
LOCUS       XP_047286867            1292 aa            linear   PRI 05-AUG-2025
DEFINITION  ATP-dependent RNA helicase TDRD9 isoform X9 [Homo sapiens].
ACCESSION   XP_047286867
VERSION     XP_047286867.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430911.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1292
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1292
                     /product="ATP-dependent RNA helicase TDRD9 isoform X9"
                     /calculated_mol_wt=146153
     Region          92..>678
                     /region_name="HrpA"
                     /note="HrpA-like RNA helicase [Translation, ribosomal
                     structure and biogenesis]; COG1643"
                     /db_xref="CDD:441249"
     Region          94..277
                     /region_name="DEXHc_TDRD9"
                     /note="DEXH-box helicase domain of tudor domain containing
                     9; cd17988"
                     /db_xref="CDD:350746"
     Site            order(94,119..125,160,216..217)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:350746"
     Region          867..967
                     /region_name="Tudor_TDRD9"
                     /note="Tudor domain found in Tudor domain-containing
                     protein 9 (TDRD9) and similar proteins; cd20431"
                     /db_xref="CDD:410502"
     Site            order(917,926,942,945,947)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410502"
     CDS             1..1292
                     /gene="TDRD9"
                     /gene_synonym="C14orf75; HIG-1; HLS; NET54; SPGF30; SPNE"
                     /coded_by="XM_047430911.1:18..3896"
                     /db_xref="GeneID:122402"
                     /db_xref="HGNC:HGNC:20122"
                     /db_xref="MIM:617963"
ORIGIN      
        1 mrdlkyhcse gphgkhengi waarskdwip ldsrslsqrs seveyinkyr qleaqeldvc
       61 rsvqptsgpg prpslaklss vtcipgttyk ypdlpisryk eevvsliesn svviihgatg
      121 sgkstqlpqy ildhyvqrsa ycsivvtqpr kigassiarw iskerawtlg gvvgyqvgle
      181 kiatedtrli ymttgvllqk ivsakslmef thiiidevhe rteemdflll vvrkllrtns
      241 rfvkvvlmsa tisckefady favpvqnkmn payifevegk phsveeyyln dlehihhskl
      301 sphlleepvi tkdiyevavs liqmfddldm kesgnkawsg aqfvlerssv lvflpglgei
      361 nymhelltsl vhkrlqvypl hssvaleeqn nvflspvpgy rkiilstnia essvtvpdvk
      421 yvidfcltrt lvcdedtnyq slrlswaskt scnqrkgrag rvsrgycyrl vhkdfwdnsi
      481 pdhvvpemlr cplgstilkv klldmgepra llatalsppg lsdiertill lkevgalavs
      541 gqredenphd geltflgrvl aqlpvnqqlg klivlghvfg cldecliiaa alslknffam
      601 pfrqhldgyr nkvnfsgssk sdcialveaf ktwkacrqtg elrypkdeln wgrlnyiqik
      661 rirevaelye elktrisqfn mhvdsrrpvm dqeyiykqrf ilqvvlagaf ypnyftfgqp
      721 deemavrela gkdpkttvvl khippygfly ykqlqslfrq cgqvksivfd gakafvefsr
      781 npterfktlp avymaikmsq lkvslelsvh saeeiegkvq gmnvsklrnt rvnvdfqkqt
      841 vdpmqvsfnt sdrsqtvtdl lltidvtevv evghfwgyri dennseilkk ltaeinqltl
      901 vplpthphpd lvclapfadf dkqryfraqv lyvsgnsaev ffvdygnksh vdlhllmeip
      961 cqflelpfqa lefkickmrp sakslvcgkh wsdgasqwfa slvsgctllv kvfsvvhsvl
     1021 hvdvyqysgv qdainirdvl iqqgyaelte esyeskaelh gpfnpyelkc hsltriskfr
     1081 cvwiekesin sviisdaped lhqrmlvaas lsinatgstm llretslmph ipglpallsm
     1141 lfapvielri dqngkyytgv lcglgwnpat gasilpehdm elafdvqfsv edvvevnilr
     1201 aainklvcdg pngckclgpe rvaqlqdiar qkllglfcqs kprekivpkw hekpyewnqv
     1261 dpklvmeqad ressrgkntf lyqlhklvvl gt
//
LOCUS       XP_047286868            1268 aa            linear   PRI 05-AUG-2025
DEFINITION  ATP-dependent RNA helicase TDRD9 isoform X10 [Homo sapiens].
ACCESSION   XP_047286868
VERSION     XP_047286868.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430912.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1268
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1268
                     /product="ATP-dependent RNA helicase TDRD9 isoform X10"
                     /calculated_mol_wt=142308
     Region          130..>654
                     /region_name="HrpA"
                     /note="HrpA-like RNA helicase [Translation, ribosomal
                     structure and biogenesis]; COG1643"
                     /db_xref="CDD:441249"
     Region          132..288
                     /region_name="DEAD-like_helicase_N"
                     /note="N-terminal helicase domain of the DEAD-box helicase
                     superfamily; cl28899"
                     /db_xref="CDD:475120"
     Site            order(157..163,254)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:350670"
     Region          843..943
                     /region_name="Tudor_TDRD9"
                     /note="Tudor domain found in Tudor domain-containing
                     protein 9 (TDRD9) and similar proteins; cd20431"
                     /db_xref="CDD:410502"
     Site            order(893,902,918,921,923)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410502"
     CDS             1..1268
                     /gene="TDRD9"
                     /gene_synonym="C14orf75; HIG-1; HLS; NET54; SPGF30; SPNE"
                     /coded_by="XM_047430912.1:55..3861"
                     /db_xref="GeneID:122402"
                     /db_xref="HGNC:HGNC:20122"
                     /db_xref="MIM:617963"
ORIGIN      
        1 mlrkltieqi ndwftigktv tnvellgapp afpagaaree vqrqdvapga gpaaqapala
       61 qaparpaaaf erslsqrsse veyinkyrql eaqeldvcrs vqptsgpgpr pslaklssvt
      121 cipgttykyp dlpisrykee vvsliesnsv viihgatgsg kstqlpqyil dhyvqrsayc
      181 sivvtqprki gassiarwis kerawtlggv vgyqvgleki atedtrliym ttgvllqkiv
      241 sakslmefth iiidevvlms atisckefad yfavpvqnkm npayifeveg kphsveeyyl
      301 ndlehihhsk lsphlleepv itkdiyevav sliqmfddld mkesgnkaws gaqfvlerss
      361 vlvflpglge inymhellts lvhkrlqvyp lhssvaleeq nnvflspvpg yrkiilstni
      421 aessvtvpdv kygragrvsr gycyrlvhkd fwdnsipdhv vpemlrcplg stilkvklld
      481 mgeprallat alsppglsdi ertilllkev galavsgqre denphdgelt flgrvlaqlp
      541 vnqqlgkliv lghvfgclde cliiaaalsl knffampfrq hldgyrnkvn fsgssksdci
      601 alveafktwk acrqtgelry pkdelnwgrl nyiqikrire vaelyeelkt risqfnmhvd
      661 srrpvmdqey iykqrfilqv vlagafypny ftfgqpdeem avrelagkdp kttvvlkhip
      721 pygflyykql qslfrqcgqv ksivfdgaka fvefsrnpte rfktlpavym aikmsqlkvs
      781 lelsvhsaee iegkvqgmnv sklrntrvnv dfqkqtvdpm qvsfntsdrs qtvtdlllti
      841 dvtevvevgh fwgyridenn seilkkltae inqltlvplp thphpdlvcl apfadfdkqr
      901 yfraqvlyvs gnsaevffvd ygnkshvdlh llmeipcqfl elpfqalefk ickmrpsaks
      961 lvcgkhwsdg asqwfaslvs gctllvkvfs vvhsvlhvdv yqysgvqdai nirdvliqqg
     1021 yaelteesye skaelhgpfn pyelkchslt riskfrcvwi ekesinsvii sdapedlhqr
     1081 mlvaaslsin atgstmllre tslmphipgl pallsmlfap vielridqng kyytgvlcgl
     1141 gwnpatgasi lpehdmelaf dvqfsvedvv evnilraain klvcdgpngc kclgpervaq
     1201 lqdiarqkll glfcqskpre kivpkwhekp yewnqvdpkl vmeqadress rgkntflyql
     1261 hklvvlgt
//
LOCUS       XP_011534704            1020 aa            linear   PRI 05-AUG-2025
DEFINITION  ATP-dependent RNA helicase TDRD9 isoform X11 [Homo sapiens].
ACCESSION   XP_011534704
VERSION     XP_011534704.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536402.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1020
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1020
                     /product="ATP-dependent RNA helicase TDRD9 isoform X11"
                     /calculated_mol_wt=115384
     Region          <22..>354
                     /region_name="HrpA"
                     /note="HrpA-like RNA helicase [Translation, ribosomal
                     structure and biogenesis]; COG1643"
                     /db_xref="CDD:441249"
     Region          <22..147
                     /region_name="SF2_C_RHA"
                     /note="C-terminal helicase domain of the RNA helicase A
                     (RHA) family helicases; cd18791"
                     /db_xref="CDD:350178"
     Site            order(69,89,91,93,137)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:350178"
     Region          543..643
                     /region_name="Tudor_TDRD9"
                     /note="Tudor domain found in Tudor domain-containing
                     protein 9 (TDRD9) and similar proteins; cd20431"
                     /db_xref="CDD:410502"
     Site            order(593,602,618,621,623)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410502"
     CDS             1..1020
                     /gene="TDRD9"
                     /gene_synonym="C14orf75; HIG-1; HLS; NET54; SPGF30; SPNE"
                     /coded_by="XM_011536402.3:92..3154"
                     /db_xref="GeneID:122402"
                     /db_xref="HGNC:HGNC:20122"
                     /db_xref="MIM:617963"
ORIGIN      
        1 miwstfiiar nkawsgaqfv lerssvlvfl pglgeinymh elltslvhkr lqvyplhssv
       61 aleeqnnvfl spvpgyrkii lstniaessv tvpdvkyvid fcltrtlvcd edtnyqslrl
      121 swasktscnq rkgragrvsr gycyrlvhkd fwdnsipdhv vpemlrcplg stilkvklld
      181 mgeprallat alsppglsdi ertilllkev galavsgqre denphdgelt flgrvlaqlp
      241 vnqqlgkliv lghvfgclde cliiaaalsl knffampfrq hldgyrnkvn fsgssksdci
      301 alveafktwk acrqtgelry pkdelnwgrl nyiqikrire vaelyeelkt risqfnmhvd
      361 srrpvmdqey iykqrfilqv vlagafypny ftfgqpdeem avrelagkdp kttvvlkhip
      421 pygflyykql qslfrqcgqv ksivfdgaka fvefsrnpte rfktlpavym aikmsqlkvs
      481 lelsvhsaee iegkvqgmnv sklrntrvnv dfqkqtvdpm qvsfntsdrs qtvtdlllti
      541 dvtevvevgh fwgyridenn seilkkltae inqltlvplp thphpdlvcl apfadfdkqr
      601 yfraqvlyvs gnsaevffvd ygnkshvdlh llmeipcqfl elpfqalefk ickmrpsaks
      661 lvcgkhwsdg asqwfaslvs gctllvkvfs vvhsvlhvdv yqysgvqdai nirdvliqqg
      721 yaelteesye skqshevlkg lfsksvenmt dgsvpfpmkd dekylirill esfstnklgt
      781 pnckaelhgp fnpyelkchs ltriskfrcv wiekesinsv iisdapedlh qrmlvaasls
      841 inatgstmll retslmphip glpallsmlf apvielridq ngkyytgvlc glgwnpatga
      901 silpehdmel afdvqfsved vvevnilraa inklvcdgpn gckclgperv aqlqdiarqk
      961 llglfcqskp rekivpkwhe kpyewnqvdp klvmeqadre ssrgkntfly qlhklvvlgt
//
LOCUS       XP_006720084             730 aa            linear   PRI 05-AUG-2025
DEFINITION  adenylate kinase 7 isoform X1 [Homo sapiens].
ACCESSION   XP_006720084
VERSION     XP_006720084.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720021.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..730
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..730
                     /product="adenylate kinase 7 isoform X1"
                     /calculated_mol_wt=83221
     Region          <168..297
                     /region_name="WcaG"
                     /note="Nucleoside-diphosphate-sugar epimerase [Cell
                     wall/membrane/envelope biogenesis]; COG0451"
                     /db_xref="CDD:440220"
     Region          369..>548
                     /region_name="ADK"
                     /note="Adenylate kinase (ADK) catalyzes the reversible
                     phosphoryl transfer from adenosine triphosphates (ATP) to
                     adenosine monophosphates (AMP) and to yield adenosine
                     diphosphates (ADP). This enzyme is required for the
                     biosynthesis of ADP and is essential for...; cd01428"
                     /db_xref="CDD:238713"
     Site            order(398,403,455,481..482,484..485,489)
                     /site_type="other"
                     /note="AMP-binding site [chemical binding]"
                     /db_xref="CDD:238713"
     Region          679..>711
                     /region_name="DD_AK7"
                     /note="dimerization/docking (D/D) domain found in
                     adenylate kinase 7 and similar proteins; cd22967"
                     /db_xref="CDD:438536"
     CDS             1..730
                     /gene="AK7"
                     /gene_synonym="AK 7; CFAP75; FAP75; SPGF27"
                     /coded_by="XM_006720021.3:28..2220"
                     /db_xref="GeneID:122481"
                     /db_xref="HGNC:HGNC:20091"
                     /db_xref="MIM:615364"
ORIGIN      
        1 maeeeetaal tekvirtqrv finlldsyss gnigkflsnc vvgasleeit eeeeeedenk
       61 samleasstk vkegtfqivg tlskpdsprp dfavetysai sredllmrll ecdviiynit
      121 essqqmeeai wavsalseev shfekrklfi llstvmtwar skaldpedse vpfteedyrr
      181 rkshpnfldh inaekmvlkf gkkarkfaay vvaaglqyga eggmlhtffk mawlgeipal
      241 pvfgdgtnvi ptihvldlag viqnvidhvp kphylvavde svhtledivk ciskntgpgk
      301 iqkiprenay ltkdltqdcl dhllvnlrme alfvkenfni rwaaqtgfve nintilkeyk
      361 qsrglmpiki cilgppavgk ssiakelany yklhhiqlkd viseaiakle aivapndvge
      421 geeeveeeee eenvedaqel ldgikesmeq nagqlddqyi irfmkeklks mpcrnqgyil
      481 dgfpktydqa kdlfnqedee eeddvrgrmf pfdkliipef vcaldasdef lkervinlpe
      541 sivagthysq drflralsny rdiniddetv fnyfdeleih pihidvgkle daqnrlaikq
      601 likeigeprn ygltdeekae eerkaaeerl areaaeeaer ehqeavemae kiarweewnk
      661 rleevkreer elleaqsipl rnylmtyvmp tliqglnecc nvrpedpvdf lvgmqwhnlg
      721 llqppppgfk
//
LOCUS       XP_006720085             704 aa            linear   PRI 05-AUG-2025
DEFINITION  adenylate kinase 7 isoform X2 [Homo sapiens].
ACCESSION   XP_006720085
VERSION     XP_006720085.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720022.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..704
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..704
                     /product="adenylate kinase 7 isoform X2"
                     /calculated_mol_wt=80349
     Region          <168..290
                     /region_name="WcaG"
                     /note="Nucleoside-diphosphate-sugar epimerase [Cell
                     wall/membrane/envelope biogenesis]; COG0451"
                     /db_xref="CDD:440220"
     Region          343..>522
                     /region_name="ADK"
                     /note="Adenylate kinase (ADK) catalyzes the reversible
                     phosphoryl transfer from adenosine triphosphates (ATP) to
                     adenosine monophosphates (AMP) and to yield adenosine
                     diphosphates (ADP). This enzyme is required for the
                     biosynthesis of ADP and is essential for...; cd01428"
                     /db_xref="CDD:238713"
     Site            order(372,377,429,455..456,458..459,463)
                     /site_type="other"
                     /note="AMP-binding site [chemical binding]"
                     /db_xref="CDD:238713"
     Region          653..>685
                     /region_name="DD_AK7"
                     /note="dimerization/docking (D/D) domain found in
                     adenylate kinase 7 and similar proteins; cd22967"
                     /db_xref="CDD:438536"
     CDS             1..704
                     /gene="AK7"
                     /gene_synonym="AK 7; CFAP75; FAP75; SPGF27"
                     /coded_by="XM_006720022.3:28..2142"
                     /db_xref="GeneID:122481"
                     /db_xref="HGNC:HGNC:20091"
                     /db_xref="MIM:615364"
ORIGIN      
        1 maeeeetaal tekvirtqrv finlldsyss gnigkflsnc vvgasleeit eeeeeedenk
       61 samleasstk vkegtfqivg tlskpdsprp dfavetysai sredllmrll ecdviiynit
      121 essqqmeeai wavsalseev shfekrklfi llstvmtwar skaldpedse vpfteedyrr
      181 rkshpnfldh inaekmvlkf gkkarkfaay vvaaglqyga eggmlhtffk mawlgeipal
      241 pvfgdgtnvi ptihvldlag viqnvidhvp kphylvavde svhtledivk qdcldhllvn
      301 lrmealfvke nfnirwaaqt gfvenintil keykqsrglm pikicilgpp avgkssiake
      361 lanyyklhhi qlkdviseai akleaivapn dvgegeeeve eeeeeenved aqelldgike
      421 smeqnagqld dqyiirfmke klksmpcrnq gyildgfpkt ydqakdlfnq edeeeeddvr
      481 grmfpfdkli ipefvcalda sdeflkervi nlpesivagt hysqdrflra lsnyrdinid
      541 detvfnyfde leihpihidv gkledaqnrl aikqlikeig eprnygltde ekaeeerkaa
      601 eerlareaae eaerehqeav emaekiarwe ewnkrleevk reerelleaq siplrnylmt
      661 yvmptliqgl neccnvrped pvdflvgmqw hnlgllqppp pgfk
//
LOCUS       XP_047286869             674 aa            linear   PRI 05-AUG-2025
DEFINITION  adenylate kinase 7 isoform X3 [Homo sapiens].
ACCESSION   XP_047286869
VERSION     XP_047286869.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430913.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..674
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..674
                     /product="adenylate kinase 7 isoform X3"
                     /calculated_mol_wt=76865
     Region          <168..290
                     /region_name="WcaG"
                     /note="Nucleoside-diphosphate-sugar epimerase [Cell
                     wall/membrane/envelope biogenesis]; COG0451"
                     /db_xref="CDD:440220"
     Region          343..>499
                     /region_name="ADK"
                     /note="Adenylate kinase (ADK) catalyzes the reversible
                     phosphoryl transfer from adenosine triphosphates (ATP) to
                     adenosine monophosphates (AMP) and to yield adenosine
                     diphosphates (ADP). This enzyme is required for the
                     biosynthesis of ADP and is essential for...; cd01428"
                     /db_xref="CDD:238713"
     Site            order(372,377,429,455..456,458..459,463)
                     /site_type="other"
                     /note="AMP-binding site [chemical binding]"
                     /db_xref="CDD:238713"
     Region          630..670
                     /region_name="DD_AK7"
                     /note="dimerization/docking (D/D) domain found in
                     adenylate kinase 7 and similar proteins; cd22967"
                     /db_xref="CDD:438536"
     CDS             1..674
                     /gene="AK7"
                     /gene_synonym="AK 7; CFAP75; FAP75; SPGF27"
                     /coded_by="XM_047430913.1:28..2052"
                     /db_xref="GeneID:122481"
                     /db_xref="HGNC:HGNC:20091"
                     /db_xref="MIM:615364"
ORIGIN      
        1 maeeeetaal tekvirtqrv finlldsyss gnigkflsnc vvgasleeit eeeeeedenk
       61 samleasstk vkegtfqivg tlskpdsprp dfavetysai sredllmrll ecdviiynit
      121 essqqmeeai wavsalseev shfekrklfi llstvmtwar skaldpedse vpfteedyrr
      181 rkshpnfldh inaekmvlkf gkkarkfaay vvaaglqyga eggmlhtffk mawlgeipal
      241 pvfgdgtnvi ptihvldlag viqnvidhvp kphylvavde svhtledivk qdcldhllvn
      301 lrmealfvke nfnirwaaqt gfvenintil keykqsrglm pikicilgpp avgkssiake
      361 lanyyklhhi qlkdviseai akleaivapn dvgegeeeve eeeeeenved aqelldgike
      421 smeqnagqld dqyiirfmke klksmpcrnq gyildgfpkt ydqakdlfnq fvcaldasde
      481 flkervinlp esivagthys qdrflralsn yrdiniddet vfnyfdelei hpihidvgkl
      541 edaqnrlaik qlikeigepr nygltdeeka eeerkaaeer lareaaeeae rehqeavema
      601 ekiarweewn krleevkree relleaqsip lrnylmtyvm ptliqglnec cnvrpedpvd
      661 flaeylfknn peaq
//
LOCUS       XP_016876447             664 aa            linear   PRI 05-AUG-2025
DEFINITION  adenylate kinase 7 isoform X4 [Homo sapiens].
ACCESSION   XP_016876447
VERSION     XP_016876447.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020958.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..664
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..664
                     /product="adenylate kinase 7 isoform X4"
                     /calculated_mol_wt=75319
     Region          <168..297
                     /region_name="WcaG"
                     /note="Nucleoside-diphosphate-sugar epimerase [Cell
                     wall/membrane/envelope biogenesis]; COG0451"
                     /db_xref="CDD:440220"
     Region          369..>482
                     /region_name="NK"
                     /note="Nucleoside/nucleotide kinase (NK) is a protein
                     superfamily consisting of multiple families of enzymes
                     that share structural similarity and are functionally
                     related to the catalysis of the reversible phosphate group
                     transfer from nucleoside triphosphates...; cl17190"
                     /db_xref="CDD:450170"
     Site            order(374,379..382)
                     /site_type="active"
                     /db_xref="CDD:238977"
     Region          613..>645
                     /region_name="DD_AK7"
                     /note="dimerization/docking (D/D) domain found in
                     adenylate kinase 7 and similar proteins; cd22967"
                     /db_xref="CDD:438536"
     CDS             1..664
                     /gene="AK7"
                     /gene_synonym="AK 7; CFAP75; FAP75; SPGF27"
                     /coded_by="XM_017020958.2:28..2022"
                     /db_xref="GeneID:122481"
                     /db_xref="HGNC:HGNC:20091"
                     /db_xref="MIM:615364"
ORIGIN      
        1 maeeeetaal tekvirtqrv finlldsyss gnigkflsnc vvgasleeit eeeeeedenk
       61 samleasstk vkegtfqivg tlskpdsprp dfavetysai sredllmrll ecdviiynit
      121 essqqmeeai wavsalseev shfekrklfi llstvmtwar skaldpedse vpfteedyrr
      181 rkshpnfldh inaekmvlkf gkkarkfaay vvaaglqyga eggmlhtffk mawlgeipal
      241 pvfgdgtnvi ptihvldlag viqnvidhvp kphylvavde svhtledivk ciskntgpgk
      301 iqkiprenay ltkdltqdcl dhllvnlrme alfvkenfni rwaaqtgfve nintilkeyk
      361 qsrglmpiki cilgppavgk ssiakelany yklhhiqlkd viseaiakle aivapndvge
      421 geeeveeeee eenvedaqel ldgikesmeq naefvcalda sdeflkervi nlpesivagt
      481 hysqdrflra lsnyrdinid detvfnyfde leihpihidv gkledaqnrl aikqlikeig
      541 eprnygltde ekaeeerkaa eerlareaae eaerehqeav emaekiarwe ewnkrleevk
      601 reerelleaq siplrnylmt yvmptliqgl neccnvrped pvdflvgmqw hnlgllqppp
      661 pgfk
//
LOCUS       XP_016876449             638 aa            linear   PRI 05-AUG-2025
DEFINITION  adenylate kinase 7 isoform X5 [Homo sapiens].
ACCESSION   XP_016876449
VERSION     XP_016876449.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020960.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..638
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..638
                     /product="adenylate kinase 7 isoform X5"
                     /calculated_mol_wt=72447
     Region          <168..290
                     /region_name="WcaG"
                     /note="Nucleoside-diphosphate-sugar epimerase [Cell
                     wall/membrane/envelope biogenesis]; COG0451"
                     /db_xref="CDD:440220"
     Region          343..>456
                     /region_name="NK"
                     /note="Nucleoside/nucleotide kinase (NK) is a protein
                     superfamily consisting of multiple families of enzymes
                     that share structural similarity and are functionally
                     related to the catalysis of the reversible phosphate group
                     transfer from nucleoside triphosphates...; cl17190"
                     /db_xref="CDD:450170"
     Site            order(348,353..356)
                     /site_type="active"
                     /db_xref="CDD:238977"
     Region          587..>619
                     /region_name="DD_AK7"
                     /note="dimerization/docking (D/D) domain found in
                     adenylate kinase 7 and similar proteins; cd22967"
                     /db_xref="CDD:438536"
     CDS             1..638
                     /gene="AK7"
                     /gene_synonym="AK 7; CFAP75; FAP75; SPGF27"
                     /coded_by="XM_017020960.2:28..1944"
                     /db_xref="GeneID:122481"
                     /db_xref="HGNC:HGNC:20091"
                     /db_xref="MIM:615364"
ORIGIN      
        1 maeeeetaal tekvirtqrv finlldsyss gnigkflsnc vvgasleeit eeeeeedenk
       61 samleasstk vkegtfqivg tlskpdsprp dfavetysai sredllmrll ecdviiynit
      121 essqqmeeai wavsalseev shfekrklfi llstvmtwar skaldpedse vpfteedyrr
      181 rkshpnfldh inaekmvlkf gkkarkfaay vvaaglqyga eggmlhtffk mawlgeipal
      241 pvfgdgtnvi ptihvldlag viqnvidhvp kphylvavde svhtledivk qdcldhllvn
      301 lrmealfvke nfnirwaaqt gfvenintil keykqsrglm pikicilgpp avgkssiake
      361 lanyyklhhi qlkdviseai akleaivapn dvgegeeeve eeeeeenved aqelldgike
      421 smeqnaefvc aldasdeflk ervinlpesi vagthysqdr flralsnyrd iniddetvfn
      481 yfdeleihpi hidvgkleda qnrlaikqli keigeprnyg ltdeekaeee rkaaeerlar
      541 eaaeeaereh qeavemaeki arweewnkrl eevkreerel leaqsiplrn ylmtyvmptl
      601 iqglneccnv rpedpvdflv gmqwhnlgll qppppgfk
//
LOCUS       XP_047286871             231 aa            linear   PRI 05-AUG-2025
DEFINITION  dopamine receptor-interacting protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047286871
VERSION     XP_047286871.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430915.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..231
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..231
                     /product="dopamine receptor-interacting protein 1 isoform
                     X1"
                     /calculated_mol_wt=26934
     CDS             1..231
                     /gene="DORIP1"
                     /gene_synonym="C14orf28; c14_5270; DRIP-1; DRIP1"
                     /coded_by="XM_047430915.1:296..991"
                     /db_xref="GeneID:122525"
                     /db_xref="HGNC:HGNC:19834"
ORIGIN      
        1 mktlfeeika siknnynqdr sfcrpvlpwg gvftikagrk avsctplyve irlkntctid
       61 gflmllyvil nenenfprel slhfgrefvd cflylmdtys fttvkllwiw dkmekqqyks
      121 evhkasliid lfgnehdnft knlenlmsti qesycsnwrc ptrvqedqqr tininppqei
      181 phgnlirlav nelfcskiel ceehgynktl vnwnpanwdp qlsgffsals i
//
LOCUS       XP_011534710             150 aa            linear   PRI 05-AUG-2025
DEFINITION  dopamine receptor-interacting protein 1 isoform X2 [Homo sapiens].
ACCESSION   XP_011534710
VERSION     XP_011534710.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536408.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..150
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..150
                     /product="dopamine receptor-interacting protein 1 isoform
                     X2"
                     /calculated_mol_wt=17349
     CDS             1..150
                     /gene="DORIP1"
                     /gene_synonym="C14orf28; c14_5270; DRIP-1; DRIP1"
                     /coded_by="XM_011536408.1:48..500"
                     /db_xref="GeneID:122525"
                     /db_xref="HGNC:HGNC:19834"
ORIGIN      
        1 msysvprlnc vksmgtikpw ltgtqligtl nyldfflhsp frrkrcgglr efsqrifchg
       61 appfvvlnmq hwksedlayv pyyldlsdhk yllegatlfn keehhysaaf qigghwmhyd
      121 glrnvnlill nkppefllls slvyiratek
//
LOCUS       XP_005267375             274 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein CLBA1 isoform X1 [Homo sapiens].
ACCESSION   XP_005267375
VERSION     XP_005267375.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267318.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..274
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..274
                     /product="uncharacterized protein CLBA1 isoform X1"
                     /calculated_mol_wt=29982
     Region          193..272
                     /region_name="Clathrin_bdg"
                     /note="Clathrin-binding box of Aftiphilin, vesicle
                     trafficking; pfam15045"
                     /db_xref="CDD:464467"
     CDS             1..274
                     /gene="CLBA1"
                     /gene_synonym="C14orf79"
                     /coded_by="XM_005267318.5:645..1469"
                     /db_xref="GeneID:122616"
                     /db_xref="HGNC:HGNC:20126"
ORIGIN      
        1 mqgrrelgge plsdlqeeaa saslrvaper lsddslewrr tcpdlllsdg kasismpreg
       61 gstctarcpd pgehsstwge fegfressak sgqfsqslel legptepqpp rttsapkecs
      121 shqpcqggpw vtgtsavpps epilsyenil kcafqeitvq qaaedvstid hfleisseek
      181 pgvervhklc nesrklwral qsihttstsq rlwsesrcqe nfflvlgida aqknlsggqg
      241 himedcdlke peglltvssf clqhckaliq tkrp
//
LOCUS       XP_011534713             462 aa            linear   PRI 05-AUG-2025
DEFINITION  5'-3' exonuclease PLD4 isoform X1 [Homo sapiens].
ACCESSION   XP_011534713
VERSION     XP_011534713.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536411.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..462
                     /product="5'-3' exonuclease PLD4 isoform X1"
                     /calculated_mol_wt=50877
     Region          105..274
                     /region_name="PLDc_vPLD4_1"
                     /note="Putative catalytic domain, repeat 1, of vertebrate
                     phospholipase PLD4; cd09145"
                     /db_xref="CDD:197243"
     Site            order(221,223,236,238,249)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:197243"
     Site            221
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:197243"
     Region          311..>447
                     /region_name="PLDc_SF"
                     /note="Catalytic domain of phospholipase D superfamily
                     proteins; cl15239"
                     /db_xref="CDD:472788"
     Site            435
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:197246"
     CDS             1..462
                     /gene="PLD4"
                     /gene_synonym="C14orf175"
                     /coded_by="XM_011536411.3:130..1518"
                     /db_xref="GeneID:122618"
                     /db_xref="HGNC:HGNC:23792"
                     /db_xref="MIM:618488"
ORIGIN      
        1 mpgcpvqmlk plwkaavapt wpcsmpprrp wdreagtlqv lgalavlwlg svalicllwq
       61 vprpptwgqv qpkdvprswe hgsspawepl eaearqqrds cqlvlvesip qdlpsaagsp
      121 saqplgqawl qlldtaqesv hvasyywslt gpdigvndss sqlgeallqk lqqllgrnis
      181 lavatssptl artstdlqvl aargahvrqv pmgrltrgvl hskfwvvdgr hiymgsanmd
      241 wrsltqvkel gaviyncshl aqdlektfqt ywvlgvpkav lpktwpqnfs shfnrfqpfh
      301 glfdgvptta yfsasppalc pqgrtrdlea llavmgsaqe fiyasvmeyf pttrfshppr
      361 ywpvldnalr aaafgkgvrv rllvgcglnt dptmfpylrs lqalsnpaan vsvdvkvfiv
      421 pvgnhsnipf srvnhskfmv tekaayiell srdqecvggk pw
//
LOCUS       XP_011534714             501 aa            linear   PRI 05-AUG-2025
DEFINITION  adenylosuccinate synthetase isozyme 1 isoform X1 [Homo sapiens].
ACCESSION   XP_011534714
VERSION     XP_011534714.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536412.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..501
                     /product="adenylosuccinate synthetase isozyme 1 isoform
                     X1"
                     /calculated_mol_wt=54359
     Region          108..498
                     /region_name="Adenylsucc_synt"
                     /note="Adenylosuccinate synthetase; pfam00709"
                     /db_xref="CDD:459912"
     CDS             1..501
                     /gene="ADSS1"
                     /gene_synonym="ADSSL1; MPD5"
                     /coded_by="XM_011536412.3:50..1555"
                     /db_xref="GeneID:122622"
                     /db_xref="HGNC:HGNC:20093"
                     /db_xref="MIM:612498"
ORIGIN      
        1 mvgrscgvat qrqgggqrpt nlaltlsssp ahstalpwlp prslqllsgh svpaqptphl
       61 psacggptrv tlgeerawrs hgsnagghtc lprrtagags ltpggerggn naghtvvvdg
      121 keydfhllps giintkavsf igngvvihlp glfeeaekne kkglkdwekr liisdrahlg
      181 dsgqqeavdg lqevqrqaqe gknigttkkg igptysskaa rtglricdll sdfdefssrf
      241 knlahqhqsm fptleidieg qlkrlkgfae rirpmvrdgv yfmyealhgp pkkilvegan
      301 aalldidfgt ypfvtssnct vggvctglgi ppqnigdvyg vvkayttrvg igafpteqin
      361 eiggllqtrg hewgvttgrk rrcgwldlmi lryahmvngf talaltkldi ldvlgevkvg
      421 vsyklngkri pyfpanqeml qkveveyetl pgwkadttga rrwedlppqa qnyirfvenh
      481 vgvavkwvgv gksresmiql f
//
LOCUS       XP_006720089             458 aa            linear   PRI 05-AUG-2025
DEFINITION  adenylosuccinate synthetase isozyme 1 isoform X2 [Homo sapiens].
ACCESSION   XP_006720089
VERSION     XP_006720089.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720026.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..458
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..458
                     /product="adenylosuccinate synthetase isozyme 1 isoform
                     X2"
                     /calculated_mol_wt=50005
     Region          35..455
                     /region_name="Adenylsucc_synt"
                     /note="Adenylosuccinate synthetase; pfam00709"
                     /db_xref="CDD:459912"
     CDS             1..458
                     /gene="ADSS1"
                     /gene_synonym="ADSSL1; MPD5"
                     /coded_by="XM_006720026.4:43..1419"
                     /db_xref="GeneID:122622"
                     /db_xref="HGNC:HGNC:20093"
                     /db_xref="MIM:612498"
ORIGIN      
        1 msgtrasndr ppgaggvkrg rlqqeaaatg srvtvvlgaq wgdegkgkvv dllatdadii
       61 srcqggnnag htvvvdgkey dfhllpsgii ntkavsfign gvvihlpglf eeaeknekkg
      121 lkdwekrlii sdrahlgdsg qqeavdglqe vqrqaqegkn igttkkgigp tysskaartg
      181 lricdllsdf defssrfknl ahqhqsmfpt leidiegqlk rlkgfaerir pmvrdgvyfm
      241 yealhgppkk ilveganaal ldidfgtypf vtssnctvgg vctglgippq nigdvygvvk
      301 ayttrvgiga fpteqineig gllqtrghew gvttgrkrrc gwldlmilry ahmvngftal
      361 altkldildv lgevkvgvsy klngkripyf panqemlqkv eveyetlpgw kadttgarrw
      421 edlppqaqny irfvenhvgv avkwvgvgks resmiqlf
//
LOCUS       XP_047286872             377 aa            linear   PRI 05-AUG-2025
DEFINITION  adenylosuccinate synthetase isozyme 1 isoform X3 [Homo sapiens].
ACCESSION   XP_047286872
VERSION     XP_047286872.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430916.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..377
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..377
                     /product="adenylosuccinate synthetase isozyme 1 isoform
                     X3"
                     /calculated_mol_wt=41716
     Region          18..374
                     /region_name="Adenylsucc_synt"
                     /note="Adenylosuccinate synthetase; pfam00709"
                     /db_xref="CDD:459912"
     CDS             1..377
                     /gene="ADSS1"
                     /gene_synonym="ADSSL1; MPD5"
                     /coded_by="XM_047430916.1:25..1158"
                     /db_xref="GeneID:122622"
                     /db_xref="HGNC:HGNC:20093"
                     /db_xref="MIM:612498"
ORIGIN      
        1 mphqsgafvt ideptltgng vvihlpglfe eaeknekkgl kdwekrliis drahlgdsgq
       61 qeavdglqev qrqaqegkni gttkkgigpt ysskaartgl ricdllsdfd efssrfknla
      121 hqhqsmfptl eidiegqlkr lkgfaerirp mvrdgvyfmy ealhgppkki lveganaall
      181 didfgtypfv tssnctvggv ctglgippqn igdvygvvka yttrvgigaf pteqineigg
      241 llqtrghewg vttgrkrrcg wldlmilrya hmvngftala ltkldildvl gevkvgvsyk
      301 lngkripyfp anqemlqkve veyetlpgwk adttgarrwe dlppqaqnyi rfvenhvgva
      361 vkwvgvgksr esmiqlf
//
LOCUS       XP_047286873             376 aa            linear   PRI 05-AUG-2025
DEFINITION  adenylosuccinate synthetase isozyme 1 isoform X4 [Homo sapiens].
ACCESSION   XP_047286873
VERSION     XP_047286873.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430917.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..376
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..376
                     /product="adenylosuccinate synthetase isozyme 1 isoform
                     X4"
                     /calculated_mol_wt=41788
     Region          18..373
                     /region_name="Adenylsucc_synt"
                     /note="Adenylosuccinate synthetase; pfam00709"
                     /db_xref="CDD:459912"
     CDS             1..376
                     /gene="ADSS1"
                     /gene_synonym="ADSSL1; MPD5"
                     /coded_by="XM_047430917.1:101..1231"
                     /db_xref="GeneID:122622"
                     /db_xref="HGNC:HGNC:20093"
                     /db_xref="MIM:612498"
ORIGIN      
        1 mphqsgafvt ideptltgng vvihlpglfe eaeknekkgl kdwekrliis drahlvfdfh
       61 qavdglqevq rqaqegknig ttkkgigpty sskaartglr icdllsdfde fssrfknlah
      121 qhqsmfptle idiegqlkrl kgfaerirpm vrdgvyfmye alhgppkkil veganaalld
      181 idfgtypfvt ssnctvggvc tglgippqni gdvygvvkay ttrvgigafp teqineiggl
      241 lqtrghewgv ttgrkrrcgw ldlmilryah mvngftalal tkldildvlg evkvgvsykl
      301 ngkripyfpa nqemlqkvev eyetlpgwka dttgarrwed lppqaqnyir fvenhvgvav
      361 kwvgvgksre smiqlf
//
LOCUS       XP_016876455             170 aa            linear   PRI 05-AUG-2025
DEFINITION  tubulin polymerization-promoting protein family member 2 isoform X1
            [Homo sapiens].
ACCESSION   XP_016876455
VERSION     XP_016876455.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020966.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..170
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..170
                     /product="tubulin polymerization-promoting protein family
                     member 2 isoform X1"
                     /calculated_mol_wt=18372
     Region          6..161
                     /region_name="p25-alpha"
                     /note="pfam05517"
                     /db_xref="CDD:461670"
     CDS             1..170
                     /gene="TPPP2"
                     /gene_synonym="C14orf8; CT152; P18; p25beta"
                     /coded_by="XM_017020966.2:116..628"
                     /db_xref="GeneID:122664"
                     /db_xref="HGNC:HGNC:19293"
                     /db_xref="MIM:616956"
ORIGIN      
        1 maseaektfh rfaafgesss sgtemnnknf sklckdcgim dgktvtstdv divfskvkak
       61 nartitfqqf keavkelgqk rfkgkspdev leniyglmeg kdpattgatk attvgavdrl
      121 tdtskytgth kerfdesgkg kgiagreemt dntgyvsgyk gsgtydkktk
//
LOCUS       XP_011534718             157 aa            linear   PRI 05-AUG-2025
DEFINITION  tubulin polymerization-promoting protein family member 2 isoform X2
            [Homo sapiens].
ACCESSION   XP_011534718
VERSION     XP_011534718.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536416.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..157
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..157
                     /product="tubulin polymerization-promoting protein family
                     member 2 isoform X2"
                     /calculated_mol_wt=17339
     Region          6..>109
                     /region_name="p25-alpha"
                     /note="pfam05517"
                     /db_xref="CDD:461670"
     CDS             1..157
                     /gene="TPPP2"
                     /gene_synonym="C14orf8; CT152; P18; p25beta"
                     /coded_by="XM_011536416.2:158..631"
                     /db_xref="GeneID:122664"
                     /db_xref="HGNC:HGNC:19293"
                     /db_xref="MIM:616956"
ORIGIN      
        1 maseaektfh rfaafgesss sgtemnnknf sklckdcgim dgktvtstdv divfskvkak
       61 nartitfqqf keavkelgqk rfkgkspdev leniyglmeg kdpattgatw mlssrldsth
      121 tptpvrlnsn isliqlqekk cdpffrlkvc nslflig
//
LOCUS       XP_011534719             124 aa            linear   PRI 05-AUG-2025
DEFINITION  tubulin polymerization-promoting protein family member 2 isoform X3
            [Homo sapiens].
ACCESSION   XP_011534719
VERSION     XP_011534719.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536417.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..124
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..124
                     /product="tubulin polymerization-promoting protein family
                     member 2 isoform X3"
                     /calculated_mol_wt=13576
     Region          6..>109
                     /region_name="p25-alpha"
                     /note="pfam05517"
                     /db_xref="CDD:461670"
     CDS             1..124
                     /gene="TPPP2"
                     /gene_synonym="C14orf8; CT152; P18; p25beta"
                     /coded_by="XM_011536417.3:158..532"
                     /db_xref="GeneID:122664"
                     /db_xref="HGNC:HGNC:19293"
                     /db_xref="MIM:616956"
ORIGIN      
        1 maseaektfh rfaafgesss sgtemnnknf sklckdcgim dgktvtstdv divfskvkak
       61 nartitfqqf keavkelgqk rfkgkspdev leniyglmeg kdpattgatl lprtgwknif
      121 gvkr
//
LOCUS       XP_011534720             124 aa            linear   PRI 05-AUG-2025
DEFINITION  tubulin polymerization-promoting protein family member 2 isoform X3
            [Homo sapiens].
ACCESSION   XP_011534720
VERSION     XP_011534720.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536418.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..124
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..124
                     /product="tubulin polymerization-promoting protein family
                     member 2 isoform X3"
                     /calculated_mol_wt=13576
     Region          6..>109
                     /region_name="p25-alpha"
                     /note="pfam05517"
                     /db_xref="CDD:461670"
     CDS             1..124
                     /gene="TPPP2"
                     /gene_synonym="C14orf8; CT152; P18; p25beta"
                     /coded_by="XM_011536418.2:158..532"
                     /db_xref="GeneID:122664"
                     /db_xref="HGNC:HGNC:19293"
                     /db_xref="MIM:616956"
ORIGIN      
        1 maseaektfh rfaafgesss sgtemnnknf sklckdcgim dgktvtstdv divfskvkak
       61 nartitfqqf keavkelgqk rfkgkspdev leniyglmeg kdpattgatl lprtgwknif
      121 gvkr
//
LOCUS       XP_011534722             124 aa            linear   PRI 05-AUG-2025
DEFINITION  tubulin polymerization-promoting protein family member 2 isoform X3
            [Homo sapiens].
ACCESSION   XP_011534722
VERSION     XP_011534722.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536420.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..124
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..124
                     /product="tubulin polymerization-promoting protein family
                     member 2 isoform X3"
                     /calculated_mol_wt=13576
     Region          6..>109
                     /region_name="p25-alpha"
                     /note="pfam05517"
                     /db_xref="CDD:461670"
     CDS             1..124
                     /gene="TPPP2"
                     /gene_synonym="C14orf8; CT152; P18; p25beta"
                     /coded_by="XM_011536420.3:158..532"
                     /db_xref="GeneID:122664"
                     /db_xref="HGNC:HGNC:19293"
                     /db_xref="MIM:616956"
ORIGIN      
        1 maseaektfh rfaafgesss sgtemnnknf sklckdcgim dgktvtstdv divfskvkak
       61 nartitfqqf keavkelgqk rfkgkspdev leniyglmeg kdpattgatl lprtgwknif
      121 gvkr
//
LOCUS       XP_005267382             111 aa            linear   PRI 05-AUG-2025
DEFINITION  large ribosomal subunit protein mL52 isoform X1 [Homo sapiens].
ACCESSION   XP_005267382
VERSION     XP_005267382.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267325.6
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..111
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..111
                     /product="large ribosomal subunit protein mL52 isoform X1"
                     /calculated_mol_wt=11621
     Region          24..>74
                     /region_name="MRPL52"
                     /note="Mitoribosomal protein mL52; pfam18699"
                     /db_xref="CDD:465836"
     CDS             1..111
                     /gene="MRPL52"
                     /gene_synonym="mL52"
                     /coded_by="XM_005267325.6:27..362"
                     /db_xref="GeneID:122704"
                     /db_xref="HGNC:HGNC:16655"
                     /db_xref="MIM:611856"
ORIGIN      
        1 maalgtvlft gvrrlhcsva awaggqwrlq qglaanpsgy gpltelpdws yadgrpappm
       61 kgqlrrkaer etfavsetsc tavtgngrwi tsmaaqaaev agrtkeagkc s
//
LOCUS       XP_047286874              64 aa            linear   PRI 05-AUG-2025
DEFINITION  large ribosomal subunit protein mL52 isoform X2 [Homo sapiens].
ACCESSION   XP_047286874
VERSION     XP_047286874.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430918.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..64
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..64
                     /product="large ribosomal subunit protein mL52 isoform X2"
                     /calculated_mol_wt=7313
     Region          <1..54
                     /region_name="MRPL52"
                     /note="Mitoribosomal protein mL52; pfam18699"
                     /db_xref="CDD:465836"
     CDS             1..64
                     /gene="MRPL52"
                     /gene_synonym="mL52"
                     /coded_by="XM_047430918.1:209..403"
                     /db_xref="GeneID:122704"
                     /db_xref="HGNC:HGNC:16655"
                     /db_xref="MIM:611856"
ORIGIN      
        1 mkgqlrrkae retfarrvvl lsqemdaglq awqlrqqklq eeqrkqenal kpkgaslksp
       61 lpsq
//
LOCUS       XP_047286875              64 aa            linear   PRI 05-AUG-2025
DEFINITION  large ribosomal subunit protein mL52 isoform X2 [Homo sapiens].
ACCESSION   XP_047286875
VERSION     XP_047286875.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430919.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..64
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..64
                     /product="large ribosomal subunit protein mL52 isoform X2"
                     /calculated_mol_wt=7313
     Region          <1..54
                     /region_name="MRPL52"
                     /note="Mitoribosomal protein mL52; pfam18699"
                     /db_xref="CDD:465836"
     CDS             1..64
                     /gene="MRPL52"
                     /gene_synonym="mL52"
                     /coded_by="XM_047430919.1:286..480"
                     /db_xref="GeneID:122704"
                     /db_xref="HGNC:HGNC:16655"
                     /db_xref="MIM:611856"
ORIGIN      
        1 mkgqlrrkae retfarrvvl lsqemdaglq awqlrqqklq eeqrkqenal kpkgaslksp
       61 lpsq
//
LOCUS       XP_011534724             354 aa            linear   PRI 05-AUG-2025
DEFINITION  kelch domain-containing protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_011534724
VERSION     XP_011534724.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536422.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..354
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..354
                     /product="kelch domain-containing protein 1 isoform X1"
                     /calculated_mol_wt=40546
     Region          <10..93
                     /region_name="NanM"
                     /note="N-acetylneuraminic acid mutarotase [Cell
                     wall/membrane/envelope biogenesis]; COG3055"
                     /db_xref="CDD:442289"
     Region          13..65
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          63..327
                     /region_name="NanM"
                     /note="N-acetylneuraminic acid mutarotase [Cell
                     wall/membrane/envelope biogenesis]; COG3055"
                     /db_xref="CDD:442289"
     Region          197..245
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          248..294
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     CDS             1..354
                     /gene="KLHDC1"
                     /gene_synonym="MST025"
                     /coded_by="XM_011536422.3:76..1140"
                     /db_xref="GeneID:122773"
                     /db_xref="HGNC:HGNC:19836"
                     /db_xref="MIM:611281"
ORIGIN      
        1 madsqlfcva eersghcavv dgnflyvwgg yvsiednevy lpndeiwtyd idsglwrmhl
       61 megelpasms gscgacingk lyifggyddk gysnrlyfvn lrtrdetyiw ekitdfegqp
      121 ptprdklscw vykdrliyfg gygcrrhsel qdcfdvhdas weeqifwgwh ndvhifdtkt
      181 qtwfqpeikg gvppqpraah tcavlgnkgy ifggrvlqtr mndlhylnld twtwsgriti
      241 ngespkhrsw htltpiaddk lflcgglsad niplsdgwih nvttncwkql thlpktrprl
      301 whtaclgken eimvfggskd dllaldtghc ndllifqtqp ysllsiwcke iksh
//
LOCUS       XP_006720092             622 aa            linear   PRI 05-AUG-2025
DEFINITION  FERM domain-containing protein 6 isoform X1 [Homo sapiens].
ACCESSION   XP_006720092
VERSION     XP_006720092.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720029.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..622
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..622
                     /product="FERM domain-containing protein 6 isoform X1"
                     /calculated_mol_wt=71913
     Region          15..120
                     /region_name="FERM_F1_FRMD6"
                     /note="FERM (Four.1 protein, Ezrin, Radixin, Moesin)
                     domain, F1 sub-domain, found in FERM domain-containing
                     protein 6 (FRMD6); cd17198"
                     /db_xref="CDD:340718"
     Region          118..234
                     /region_name="FERM_M"
                     /note="FERM central domain; pfam00373"
                     /db_xref="CDD:459788"
     Region          227..335
                     /region_name="FERM_C_FRMD1_FRMD6"
                     /note="FERM domain C-lobe of FERM domain containing 1 and
                     6 proteins; cd13185"
                     /db_xref="CDD:270006"
     Site            order(241,258,260,270)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:270006"
     Site            order(274,279..282,314,318,321..322)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270006"
     Site            314..325
                     /site_type="other"
                     /note="putative actin binding site 2 [polypeptide
                     binding]"
                     /db_xref="CDD:270006"
     CDS             1..622
                     /gene="FRMD6"
                     /gene_synonym="C14orf31; c14_5320; EX1; Willin"
                     /coded_by="XM_006720029.2:455..2323"
                     /db_xref="GeneID:122786"
                     /db_xref="HGNC:HGNC:19839"
                     /db_xref="MIM:614555"
ORIGIN      
        1 mnklnfhnnr vmqdrrsvci flpndeslni iinvkilchq llvqvcdllr lkdchlfgls
       61 viqnnehvym elsqklykyc pkewkkeask vrqyevtwgi dqfgppmiih frvqyyveng
      121 rlisdraary yyywhlrkqv lhsqcvlree ayfllaafal qadlgnfkrn khygkyfepe
      181 ayfpswvvsk rgkdyilkhi pnmhkdqfal taseahlkyi keavrlddva vhyyrlykdk
      241 reieasltlg ltmrgiqifq nldeekqlly dfpwtnvgkl vfvgkkfeil pdglpsarkl
      301 iyytgcpmrs rhllqllsns hrlymnlqpv lrhirkleen eekkqyresy isdnldldmd
      361 qlekrsrasg ssagsmkhkr lsrhstashs sshtsgiead tkprdtgped sysssaihrk
      421 lktcssmtsh gsshtsgves ggkdrleedl qddeiemlvd dprdleqmne eslevspdmc
      481 iyitedmlms rklnghsgli vkeigsstss ssetvvklrg qstdslpqti crkpktstdr
      541 hslslddirl yqkdflriag lcqdtaqsyt fgcgheldee glycnsclaq qciniqdafp
      601 vkrtskyfsl dlthdevpef vv
//
LOCUS       XP_024305242             622 aa            linear   PRI 05-AUG-2025
DEFINITION  FERM domain-containing protein 6 isoform X1 [Homo sapiens].
ACCESSION   XP_024305242
VERSION     XP_024305242.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449474.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..622
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..622
                     /product="FERM domain-containing protein 6 isoform X1"
                     /calculated_mol_wt=71913
     Region          15..120
                     /region_name="FERM_F1_FRMD6"
                     /note="FERM (Four.1 protein, Ezrin, Radixin, Moesin)
                     domain, F1 sub-domain, found in FERM domain-containing
                     protein 6 (FRMD6); cd17198"
                     /db_xref="CDD:340718"
     Region          118..234
                     /region_name="FERM_M"
                     /note="FERM central domain; pfam00373"
                     /db_xref="CDD:459788"
     Region          227..335
                     /region_name="FERM_C_FRMD1_FRMD6"
                     /note="FERM domain C-lobe of FERM domain containing 1 and
                     6 proteins; cd13185"
                     /db_xref="CDD:270006"
     Site            order(241,258,260,270)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:270006"
     Site            order(274,279..282,314,318,321..322)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270006"
     Site            314..325
                     /site_type="other"
                     /note="putative actin binding site 2 [polypeptide
                     binding]"
                     /db_xref="CDD:270006"
     CDS             1..622
                     /gene="FRMD6"
                     /gene_synonym="C14orf31; c14_5320; EX1; Willin"
                     /coded_by="XM_024449474.2:1028..2896"
                     /db_xref="GeneID:122786"
                     /db_xref="HGNC:HGNC:19839"
                     /db_xref="MIM:614555"
ORIGIN      
        1 mnklnfhnnr vmqdrrsvci flpndeslni iinvkilchq llvqvcdllr lkdchlfgls
       61 viqnnehvym elsqklykyc pkewkkeask vrqyevtwgi dqfgppmiih frvqyyveng
      121 rlisdraary yyywhlrkqv lhsqcvlree ayfllaafal qadlgnfkrn khygkyfepe
      181 ayfpswvvsk rgkdyilkhi pnmhkdqfal taseahlkyi keavrlddva vhyyrlykdk
      241 reieasltlg ltmrgiqifq nldeekqlly dfpwtnvgkl vfvgkkfeil pdglpsarkl
      301 iyytgcpmrs rhllqllsns hrlymnlqpv lrhirkleen eekkqyresy isdnldldmd
      361 qlekrsrasg ssagsmkhkr lsrhstashs sshtsgiead tkprdtgped sysssaihrk
      421 lktcssmtsh gsshtsgves ggkdrleedl qddeiemlvd dprdleqmne eslevspdmc
      481 iyitedmlms rklnghsgli vkeigsstss ssetvvklrg qstdslpqti crkpktstdr
      541 hslslddirl yqkdflriag lcqdtaqsyt fgcgheldee glycnsclaq qciniqdafp
      601 vkrtskyfsl dlthdevpef vv
//
LOCUS       XP_047286876             622 aa            linear   PRI 05-AUG-2025
DEFINITION  FERM domain-containing protein 6 isoform X1 [Homo sapiens].
ACCESSION   XP_047286876
VERSION     XP_047286876.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430920.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..622
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..622
                     /product="FERM domain-containing protein 6 isoform X1"
                     /calculated_mol_wt=71913
     Region          15..120
                     /region_name="FERM_F1_FRMD6"
                     /note="FERM (Four.1 protein, Ezrin, Radixin, Moesin)
                     domain, F1 sub-domain, found in FERM domain-containing
                     protein 6 (FRMD6); cd17198"
                     /db_xref="CDD:340718"
     Region          118..234
                     /region_name="FERM_M"
                     /note="FERM central domain; pfam00373"
                     /db_xref="CDD:459788"
     Region          227..335
                     /region_name="FERM_C_FRMD1_FRMD6"
                     /note="FERM domain C-lobe of FERM domain containing 1 and
                     6 proteins; cd13185"
                     /db_xref="CDD:270006"
     Site            order(241,258,260,270)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:270006"
     Site            order(274,279..282,314,318,321..322)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270006"
     Site            314..325
                     /site_type="other"
                     /note="putative actin binding site 2 [polypeptide
                     binding]"
                     /db_xref="CDD:270006"
     CDS             1..622
                     /gene="FRMD6"
                     /gene_synonym="C14orf31; c14_5320; EX1; Willin"
                     /coded_by="XM_047430920.1:843..2711"
                     /db_xref="GeneID:122786"
                     /db_xref="HGNC:HGNC:19839"
                     /db_xref="MIM:614555"
ORIGIN      
        1 mnklnfhnnr vmqdrrsvci flpndeslni iinvkilchq llvqvcdllr lkdchlfgls
       61 viqnnehvym elsqklykyc pkewkkeask vrqyevtwgi dqfgppmiih frvqyyveng
      121 rlisdraary yyywhlrkqv lhsqcvlree ayfllaafal qadlgnfkrn khygkyfepe
      181 ayfpswvvsk rgkdyilkhi pnmhkdqfal taseahlkyi keavrlddva vhyyrlykdk
      241 reieasltlg ltmrgiqifq nldeekqlly dfpwtnvgkl vfvgkkfeil pdglpsarkl
      301 iyytgcpmrs rhllqllsns hrlymnlqpv lrhirkleen eekkqyresy isdnldldmd
      361 qlekrsrasg ssagsmkhkr lsrhstashs sshtsgiead tkprdtgped sysssaihrk
      421 lktcssmtsh gsshtsgves ggkdrleedl qddeiemlvd dprdleqmne eslevspdmc
      481 iyitedmlms rklnghsgli vkeigsstss ssetvvklrg qstdslpqti crkpktstdr
      541 hslslddirl yqkdflriag lcqdtaqsyt fgcgheldee glycnsclaq qciniqdafp
      601 vkrtskyfsl dlthdevpef vv
//
LOCUS       XP_047286877             622 aa            linear   PRI 05-AUG-2025
DEFINITION  FERM domain-containing protein 6 isoform X1 [Homo sapiens].
ACCESSION   XP_047286877
VERSION     XP_047286877.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430921.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..622
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..622
                     /product="FERM domain-containing protein 6 isoform X1"
                     /calculated_mol_wt=71913
     Region          15..120
                     /region_name="FERM_F1_FRMD6"
                     /note="FERM (Four.1 protein, Ezrin, Radixin, Moesin)
                     domain, F1 sub-domain, found in FERM domain-containing
                     protein 6 (FRMD6); cd17198"
                     /db_xref="CDD:340718"
     Region          118..234
                     /region_name="FERM_M"
                     /note="FERM central domain; pfam00373"
                     /db_xref="CDD:459788"
     Region          227..335
                     /region_name="FERM_C_FRMD1_FRMD6"
                     /note="FERM domain C-lobe of FERM domain containing 1 and
                     6 proteins; cd13185"
                     /db_xref="CDD:270006"
     Site            order(241,258,260,270)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:270006"
     Site            order(274,279..282,314,318,321..322)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270006"
     Site            314..325
                     /site_type="other"
                     /note="putative actin binding site 2 [polypeptide
                     binding]"
                     /db_xref="CDD:270006"
     CDS             1..622
                     /gene="FRMD6"
                     /gene_synonym="C14orf31; c14_5320; EX1; Willin"
                     /coded_by="XM_047430921.1:627..2495"
                     /db_xref="GeneID:122786"
                     /db_xref="HGNC:HGNC:19839"
                     /db_xref="MIM:614555"
ORIGIN      
        1 mnklnfhnnr vmqdrrsvci flpndeslni iinvkilchq llvqvcdllr lkdchlfgls
       61 viqnnehvym elsqklykyc pkewkkeask vrqyevtwgi dqfgppmiih frvqyyveng
      121 rlisdraary yyywhlrkqv lhsqcvlree ayfllaafal qadlgnfkrn khygkyfepe
      181 ayfpswvvsk rgkdyilkhi pnmhkdqfal taseahlkyi keavrlddva vhyyrlykdk
      241 reieasltlg ltmrgiqifq nldeekqlly dfpwtnvgkl vfvgkkfeil pdglpsarkl
      301 iyytgcpmrs rhllqllsns hrlymnlqpv lrhirkleen eekkqyresy isdnldldmd
      361 qlekrsrasg ssagsmkhkr lsrhstashs sshtsgiead tkprdtgped sysssaihrk
      421 lktcssmtsh gsshtsgves ggkdrleedl qddeiemlvd dprdleqmne eslevspdmc
      481 iyitedmlms rklnghsgli vkeigsstss ssetvvklrg qstdslpqti crkpktstdr
      541 hslslddirl yqkdflriag lcqdtaqsyt fgcgheldee glycnsclaq qciniqdafp
      601 vkrtskyfsl dlthdevpef vv
//
LOCUS       XP_047286878             622 aa            linear   PRI 05-AUG-2025
DEFINITION  FERM domain-containing protein 6 isoform X1 [Homo sapiens].
ACCESSION   XP_047286878
VERSION     XP_047286878.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430922.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..622
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..622
                     /product="FERM domain-containing protein 6 isoform X1"
                     /calculated_mol_wt=71913
     Region          15..120
                     /region_name="FERM_F1_FRMD6"
                     /note="FERM (Four.1 protein, Ezrin, Radixin, Moesin)
                     domain, F1 sub-domain, found in FERM domain-containing
                     protein 6 (FRMD6); cd17198"
                     /db_xref="CDD:340718"
     Region          118..234
                     /region_name="FERM_M"
                     /note="FERM central domain; pfam00373"
                     /db_xref="CDD:459788"
     Region          227..335
                     /region_name="FERM_C_FRMD1_FRMD6"
                     /note="FERM domain C-lobe of FERM domain containing 1 and
                     6 proteins; cd13185"
                     /db_xref="CDD:270006"
     Site            order(241,258,260,270)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:270006"
     Site            order(274,279..282,314,318,321..322)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270006"
     Site            314..325
                     /site_type="other"
                     /note="putative actin binding site 2 [polypeptide
                     binding]"
                     /db_xref="CDD:270006"
     CDS             1..622
                     /gene="FRMD6"
                     /gene_synonym="C14orf31; c14_5320; EX1; Willin"
                     /coded_by="XM_047430922.1:658..2526"
                     /db_xref="GeneID:122786"
                     /db_xref="HGNC:HGNC:19839"
                     /db_xref="MIM:614555"
ORIGIN      
        1 mnklnfhnnr vmqdrrsvci flpndeslni iinvkilchq llvqvcdllr lkdchlfgls
       61 viqnnehvym elsqklykyc pkewkkeask vrqyevtwgi dqfgppmiih frvqyyveng
      121 rlisdraary yyywhlrkqv lhsqcvlree ayfllaafal qadlgnfkrn khygkyfepe
      181 ayfpswvvsk rgkdyilkhi pnmhkdqfal taseahlkyi keavrlddva vhyyrlykdk
      241 reieasltlg ltmrgiqifq nldeekqlly dfpwtnvgkl vfvgkkfeil pdglpsarkl
      301 iyytgcpmrs rhllqllsns hrlymnlqpv lrhirkleen eekkqyresy isdnldldmd
      361 qlekrsrasg ssagsmkhkr lsrhstashs sshtsgiead tkprdtgped sysssaihrk
      421 lktcssmtsh gsshtsgves ggkdrleedl qddeiemlvd dprdleqmne eslevspdmc
      481 iyitedmlms rklnghsgli vkeigsstss ssetvvklrg qstdslpqti crkpktstdr
      541 hslslddirl yqkdflriag lcqdtaqsyt fgcgheldee glycnsclaq qciniqdafp
      601 vkrtskyfsl dlthdevpef vv
//
LOCUS       XP_024305243             622 aa            linear   PRI 05-AUG-2025
DEFINITION  FERM domain-containing protein 6 isoform X1 [Homo sapiens].
ACCESSION   XP_024305243
VERSION     XP_024305243.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449475.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..622
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..622
                     /product="FERM domain-containing protein 6 isoform X1"
                     /calculated_mol_wt=71913
     Region          15..120
                     /region_name="FERM_F1_FRMD6"
                     /note="FERM (Four.1 protein, Ezrin, Radixin, Moesin)
                     domain, F1 sub-domain, found in FERM domain-containing
                     protein 6 (FRMD6); cd17198"
                     /db_xref="CDD:340718"
     Region          118..234
                     /region_name="FERM_M"
                     /note="FERM central domain; pfam00373"
                     /db_xref="CDD:459788"
     Region          227..335
                     /region_name="FERM_C_FRMD1_FRMD6"
                     /note="FERM domain C-lobe of FERM domain containing 1 and
                     6 proteins; cd13185"
                     /db_xref="CDD:270006"
     Site            order(241,258,260,270)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:270006"
     Site            order(274,279..282,314,318,321..322)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270006"
     Site            314..325
                     /site_type="other"
                     /note="putative actin binding site 2 [polypeptide
                     binding]"
                     /db_xref="CDD:270006"
     CDS             1..622
                     /gene="FRMD6"
                     /gene_synonym="C14orf31; c14_5320; EX1; Willin"
                     /coded_by="XM_024449475.2:1104..2972"
                     /db_xref="GeneID:122786"
                     /db_xref="HGNC:HGNC:19839"
                     /db_xref="MIM:614555"
ORIGIN      
        1 mnklnfhnnr vmqdrrsvci flpndeslni iinvkilchq llvqvcdllr lkdchlfgls
       61 viqnnehvym elsqklykyc pkewkkeask vrqyevtwgi dqfgppmiih frvqyyveng
      121 rlisdraary yyywhlrkqv lhsqcvlree ayfllaafal qadlgnfkrn khygkyfepe
      181 ayfpswvvsk rgkdyilkhi pnmhkdqfal taseahlkyi keavrlddva vhyyrlykdk
      241 reieasltlg ltmrgiqifq nldeekqlly dfpwtnvgkl vfvgkkfeil pdglpsarkl
      301 iyytgcpmrs rhllqllsns hrlymnlqpv lrhirkleen eekkqyresy isdnldldmd
      361 qlekrsrasg ssagsmkhkr lsrhstashs sshtsgiead tkprdtgped sysssaihrk
      421 lktcssmtsh gsshtsgves ggkdrleedl qddeiemlvd dprdleqmne eslevspdmc
      481 iyitedmlms rklnghsgli vkeigsstss ssetvvklrg qstdslpqti crkpktstdr
      541 hslslddirl yqkdflriag lcqdtaqsyt fgcgheldee glycnsclaq qciniqdafp
      601 vkrtskyfsl dlthdevpef vv
//
LOCUS       XP_047286879             622 aa            linear   PRI 05-AUG-2025
DEFINITION  FERM domain-containing protein 6 isoform X1 [Homo sapiens].
ACCESSION   XP_047286879
VERSION     XP_047286879.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430923.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..622
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..622
                     /product="FERM domain-containing protein 6 isoform X1"
                     /calculated_mol_wt=71913
     Region          15..120
                     /region_name="FERM_F1_FRMD6"
                     /note="FERM (Four.1 protein, Ezrin, Radixin, Moesin)
                     domain, F1 sub-domain, found in FERM domain-containing
                     protein 6 (FRMD6); cd17198"
                     /db_xref="CDD:340718"
     Region          118..234
                     /region_name="FERM_M"
                     /note="FERM central domain; pfam00373"
                     /db_xref="CDD:459788"
     Region          227..335
                     /region_name="FERM_C_FRMD1_FRMD6"
                     /note="FERM domain C-lobe of FERM domain containing 1 and
                     6 proteins; cd13185"
                     /db_xref="CDD:270006"
     Site            order(241,258,260,270)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:270006"
     Site            order(274,279..282,314,318,321..322)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270006"
     Site            314..325
                     /site_type="other"
                     /note="putative actin binding site 2 [polypeptide
                     binding]"
                     /db_xref="CDD:270006"
     CDS             1..622
                     /gene="FRMD6"
                     /gene_synonym="C14orf31; c14_5320; EX1; Willin"
                     /coded_by="XM_047430923.1:5298..7166"
                     /db_xref="GeneID:122786"
                     /db_xref="HGNC:HGNC:19839"
                     /db_xref="MIM:614555"
ORIGIN      
        1 mnklnfhnnr vmqdrrsvci flpndeslni iinvkilchq llvqvcdllr lkdchlfgls
       61 viqnnehvym elsqklykyc pkewkkeask vrqyevtwgi dqfgppmiih frvqyyveng
      121 rlisdraary yyywhlrkqv lhsqcvlree ayfllaafal qadlgnfkrn khygkyfepe
      181 ayfpswvvsk rgkdyilkhi pnmhkdqfal taseahlkyi keavrlddva vhyyrlykdk
      241 reieasltlg ltmrgiqifq nldeekqlly dfpwtnvgkl vfvgkkfeil pdglpsarkl
      301 iyytgcpmrs rhllqllsns hrlymnlqpv lrhirkleen eekkqyresy isdnldldmd
      361 qlekrsrasg ssagsmkhkr lsrhstashs sshtsgiead tkprdtgped sysssaihrk
      421 lktcssmtsh gsshtsgves ggkdrleedl qddeiemlvd dprdleqmne eslevspdmc
      481 iyitedmlms rklnghsgli vkeigsstss ssetvvklrg qstdslpqti crkpktstdr
      541 hslslddirl yqkdflriag lcqdtaqsyt fgcgheldee glycnsclaq qciniqdafp
      601 vkrtskyfsl dlthdevpef vv
//
LOCUS       XP_047286881             622 aa            linear   PRI 05-AUG-2025
DEFINITION  FERM domain-containing protein 6 isoform X1 [Homo sapiens].
ACCESSION   XP_047286881
VERSION     XP_047286881.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430925.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..622
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..622
                     /product="FERM domain-containing protein 6 isoform X1"
                     /calculated_mol_wt=71913
     Region          15..120
                     /region_name="FERM_F1_FRMD6"
                     /note="FERM (Four.1 protein, Ezrin, Radixin, Moesin)
                     domain, F1 sub-domain, found in FERM domain-containing
                     protein 6 (FRMD6); cd17198"
                     /db_xref="CDD:340718"
     Region          118..234
                     /region_name="FERM_M"
                     /note="FERM central domain; pfam00373"
                     /db_xref="CDD:459788"
     Region          227..335
                     /region_name="FERM_C_FRMD1_FRMD6"
                     /note="FERM domain C-lobe of FERM domain containing 1 and
                     6 proteins; cd13185"
                     /db_xref="CDD:270006"
     Site            order(241,258,260,270)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:270006"
     Site            order(274,279..282,314,318,321..322)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270006"
     Site            314..325
                     /site_type="other"
                     /note="putative actin binding site 2 [polypeptide
                     binding]"
                     /db_xref="CDD:270006"
     CDS             1..622
                     /gene="FRMD6"
                     /gene_synonym="C14orf31; c14_5320; EX1; Willin"
                     /coded_by="XM_047430925.1:691..2559"
                     /db_xref="GeneID:122786"
                     /db_xref="HGNC:HGNC:19839"
                     /db_xref="MIM:614555"
ORIGIN      
        1 mnklnfhnnr vmqdrrsvci flpndeslni iinvkilchq llvqvcdllr lkdchlfgls
       61 viqnnehvym elsqklykyc pkewkkeask vrqyevtwgi dqfgppmiih frvqyyveng
      121 rlisdraary yyywhlrkqv lhsqcvlree ayfllaafal qadlgnfkrn khygkyfepe
      181 ayfpswvvsk rgkdyilkhi pnmhkdqfal taseahlkyi keavrlddva vhyyrlykdk
      241 reieasltlg ltmrgiqifq nldeekqlly dfpwtnvgkl vfvgkkfeil pdglpsarkl
      301 iyytgcpmrs rhllqllsns hrlymnlqpv lrhirkleen eekkqyresy isdnldldmd
      361 qlekrsrasg ssagsmkhkr lsrhstashs sshtsgiead tkprdtgped sysssaihrk
      421 lktcssmtsh gsshtsgves ggkdrleedl qddeiemlvd dprdleqmne eslevspdmc
      481 iyitedmlms rklnghsgli vkeigsstss ssetvvklrg qstdslpqti crkpktstdr
      541 hslslddirl yqkdflriag lcqdtaqsyt fgcgheldee glycnsclaq qciniqdafp
      601 vkrtskyfsl dlthdevpef vv
//
LOCUS       XP_047286882             622 aa            linear   PRI 05-AUG-2025
DEFINITION  FERM domain-containing protein 6 isoform X1 [Homo sapiens].
ACCESSION   XP_047286882
VERSION     XP_047286882.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430926.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..622
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..622
                     /product="FERM domain-containing protein 6 isoform X1"
                     /calculated_mol_wt=71913
     Region          15..120
                     /region_name="FERM_F1_FRMD6"
                     /note="FERM (Four.1 protein, Ezrin, Radixin, Moesin)
                     domain, F1 sub-domain, found in FERM domain-containing
                     protein 6 (FRMD6); cd17198"
                     /db_xref="CDD:340718"
     Region          118..234
                     /region_name="FERM_M"
                     /note="FERM central domain; pfam00373"
                     /db_xref="CDD:459788"
     Region          227..335
                     /region_name="FERM_C_FRMD1_FRMD6"
                     /note="FERM domain C-lobe of FERM domain containing 1 and
                     6 proteins; cd13185"
                     /db_xref="CDD:270006"
     Site            order(241,258,260,270)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:270006"
     Site            order(274,279..282,314,318,321..322)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270006"
     Site            314..325
                     /site_type="other"
                     /note="putative actin binding site 2 [polypeptide
                     binding]"
                     /db_xref="CDD:270006"
     CDS             1..622
                     /gene="FRMD6"
                     /gene_synonym="C14orf31; c14_5320; EX1; Willin"
                     /coded_by="XM_047430926.1:730..2598"
                     /db_xref="GeneID:122786"
                     /db_xref="HGNC:HGNC:19839"
                     /db_xref="MIM:614555"
ORIGIN      
        1 mnklnfhnnr vmqdrrsvci flpndeslni iinvkilchq llvqvcdllr lkdchlfgls
       61 viqnnehvym elsqklykyc pkewkkeask vrqyevtwgi dqfgppmiih frvqyyveng
      121 rlisdraary yyywhlrkqv lhsqcvlree ayfllaafal qadlgnfkrn khygkyfepe
      181 ayfpswvvsk rgkdyilkhi pnmhkdqfal taseahlkyi keavrlddva vhyyrlykdk
      241 reieasltlg ltmrgiqifq nldeekqlly dfpwtnvgkl vfvgkkfeil pdglpsarkl
      301 iyytgcpmrs rhllqllsns hrlymnlqpv lrhirkleen eekkqyresy isdnldldmd
      361 qlekrsrasg ssagsmkhkr lsrhstashs sshtsgiead tkprdtgped sysssaihrk
      421 lktcssmtsh gsshtsgves ggkdrleedl qddeiemlvd dprdleqmne eslevspdmc
      481 iyitedmlms rklnghsgli vkeigsstss ssetvvklrg qstdslpqti crkpktstdr
      541 hslslddirl yqkdflriag lcqdtaqsyt fgcgheldee glycnsclaq qciniqdafp
      601 vkrtskyfsl dlthdevpef vv
//
LOCUS       XP_047286883             622 aa            linear   PRI 05-AUG-2025
DEFINITION  FERM domain-containing protein 6 isoform X1 [Homo sapiens].
ACCESSION   XP_047286883
VERSION     XP_047286883.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430927.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..622
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..622
                     /product="FERM domain-containing protein 6 isoform X1"
                     /calculated_mol_wt=71913
     Region          15..120
                     /region_name="FERM_F1_FRMD6"
                     /note="FERM (Four.1 protein, Ezrin, Radixin, Moesin)
                     domain, F1 sub-domain, found in FERM domain-containing
                     protein 6 (FRMD6); cd17198"
                     /db_xref="CDD:340718"
     Region          118..234
                     /region_name="FERM_M"
                     /note="FERM central domain; pfam00373"
                     /db_xref="CDD:459788"
     Region          227..335
                     /region_name="FERM_C_FRMD1_FRMD6"
                     /note="FERM domain C-lobe of FERM domain containing 1 and
                     6 proteins; cd13185"
                     /db_xref="CDD:270006"
     Site            order(241,258,260,270)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:270006"
     Site            order(274,279..282,314,318,321..322)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270006"
     Site            314..325
                     /site_type="other"
                     /note="putative actin binding site 2 [polypeptide
                     binding]"
                     /db_xref="CDD:270006"
     CDS             1..622
                     /gene="FRMD6"
                     /gene_synonym="C14orf31; c14_5320; EX1; Willin"
                     /coded_by="XM_047430927.1:565..2433"
                     /db_xref="GeneID:122786"
                     /db_xref="HGNC:HGNC:19839"
                     /db_xref="MIM:614555"
ORIGIN      
        1 mnklnfhnnr vmqdrrsvci flpndeslni iinvkilchq llvqvcdllr lkdchlfgls
       61 viqnnehvym elsqklykyc pkewkkeask vrqyevtwgi dqfgppmiih frvqyyveng
      121 rlisdraary yyywhlrkqv lhsqcvlree ayfllaafal qadlgnfkrn khygkyfepe
      181 ayfpswvvsk rgkdyilkhi pnmhkdqfal taseahlkyi keavrlddva vhyyrlykdk
      241 reieasltlg ltmrgiqifq nldeekqlly dfpwtnvgkl vfvgkkfeil pdglpsarkl
      301 iyytgcpmrs rhllqllsns hrlymnlqpv lrhirkleen eekkqyresy isdnldldmd
      361 qlekrsrasg ssagsmkhkr lsrhstashs sshtsgiead tkprdtgped sysssaihrk
      421 lktcssmtsh gsshtsgves ggkdrleedl qddeiemlvd dprdleqmne eslevspdmc
      481 iyitedmlms rklnghsgli vkeigsstss ssetvvklrg qstdslpqti crkpktstdr
      541 hslslddirl yqkdflriag lcqdtaqsyt fgcgheldee glycnsclaq qciniqdafp
      601 vkrtskyfsl dlthdevpef vv
//
LOCUS       XP_024305241             622 aa            linear   PRI 05-AUG-2025
DEFINITION  FERM domain-containing protein 6 isoform X1 [Homo sapiens].
ACCESSION   XP_024305241
VERSION     XP_024305241.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449473.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..622
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..622
                     /product="FERM domain-containing protein 6 isoform X1"
                     /calculated_mol_wt=71913
     Region          15..120
                     /region_name="FERM_F1_FRMD6"
                     /note="FERM (Four.1 protein, Ezrin, Radixin, Moesin)
                     domain, F1 sub-domain, found in FERM domain-containing
                     protein 6 (FRMD6); cd17198"
                     /db_xref="CDD:340718"
     Region          118..234
                     /region_name="FERM_M"
                     /note="FERM central domain; pfam00373"
                     /db_xref="CDD:459788"
     Region          227..335
                     /region_name="FERM_C_FRMD1_FRMD6"
                     /note="FERM domain C-lobe of FERM domain containing 1 and
                     6 proteins; cd13185"
                     /db_xref="CDD:270006"
     Site            order(241,258,260,270)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:270006"
     Site            order(274,279..282,314,318,321..322)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270006"
     Site            314..325
                     /site_type="other"
                     /note="putative actin binding site 2 [polypeptide
                     binding]"
                     /db_xref="CDD:270006"
     CDS             1..622
                     /gene="FRMD6"
                     /gene_synonym="C14orf31; c14_5320; EX1; Willin"
                     /coded_by="XM_024449473.2:440..2308"
                     /db_xref="GeneID:122786"
                     /db_xref="HGNC:HGNC:19839"
                     /db_xref="MIM:614555"
ORIGIN      
        1 mnklnfhnnr vmqdrrsvci flpndeslni iinvkilchq llvqvcdllr lkdchlfgls
       61 viqnnehvym elsqklykyc pkewkkeask vrqyevtwgi dqfgppmiih frvqyyveng
      121 rlisdraary yyywhlrkqv lhsqcvlree ayfllaafal qadlgnfkrn khygkyfepe
      181 ayfpswvvsk rgkdyilkhi pnmhkdqfal taseahlkyi keavrlddva vhyyrlykdk
      241 reieasltlg ltmrgiqifq nldeekqlly dfpwtnvgkl vfvgkkfeil pdglpsarkl
      301 iyytgcpmrs rhllqllsns hrlymnlqpv lrhirkleen eekkqyresy isdnldldmd
      361 qlekrsrasg ssagsmkhkr lsrhstashs sshtsgiead tkprdtgped sysssaihrk
      421 lktcssmtsh gsshtsgves ggkdrleedl qddeiemlvd dprdleqmne eslevspdmc
      481 iyitedmlms rklnghsgli vkeigsstss ssetvvklrg qstdslpqti crkpktstdr
      541 hslslddirl yqkdflriag lcqdtaqsyt fgcgheldee glycnsclaq qciniqdafp
      601 vkrtskyfsl dlthdevpef vv
//
LOCUS       XP_011534726             622 aa            linear   PRI 05-AUG-2025
DEFINITION  FERM domain-containing protein 6 isoform X1 [Homo sapiens].
ACCESSION   XP_011534726
VERSION     XP_011534726.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536424.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..622
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..622
                     /product="FERM domain-containing protein 6 isoform X1"
                     /calculated_mol_wt=71913
     Region          15..120
                     /region_name="FERM_F1_FRMD6"
                     /note="FERM (Four.1 protein, Ezrin, Radixin, Moesin)
                     domain, F1 sub-domain, found in FERM domain-containing
                     protein 6 (FRMD6); cd17198"
                     /db_xref="CDD:340718"
     Region          118..234
                     /region_name="FERM_M"
                     /note="FERM central domain; pfam00373"
                     /db_xref="CDD:459788"
     Region          227..335
                     /region_name="FERM_C_FRMD1_FRMD6"
                     /note="FERM domain C-lobe of FERM domain containing 1 and
                     6 proteins; cd13185"
                     /db_xref="CDD:270006"
     Site            order(241,258,260,270)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:270006"
     Site            order(274,279..282,314,318,321..322)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270006"
     Site            314..325
                     /site_type="other"
                     /note="putative actin binding site 2 [polypeptide
                     binding]"
                     /db_xref="CDD:270006"
     CDS             1..622
                     /gene="FRMD6"
                     /gene_synonym="C14orf31; c14_5320; EX1; Willin"
                     /coded_by="XM_011536424.2:627..2495"
                     /db_xref="GeneID:122786"
                     /db_xref="HGNC:HGNC:19839"
                     /db_xref="MIM:614555"
ORIGIN      
        1 mnklnfhnnr vmqdrrsvci flpndeslni iinvkilchq llvqvcdllr lkdchlfgls
       61 viqnnehvym elsqklykyc pkewkkeask vrqyevtwgi dqfgppmiih frvqyyveng
      121 rlisdraary yyywhlrkqv lhsqcvlree ayfllaafal qadlgnfkrn khygkyfepe
      181 ayfpswvvsk rgkdyilkhi pnmhkdqfal taseahlkyi keavrlddva vhyyrlykdk
      241 reieasltlg ltmrgiqifq nldeekqlly dfpwtnvgkl vfvgkkfeil pdglpsarkl
      301 iyytgcpmrs rhllqllsns hrlymnlqpv lrhirkleen eekkqyresy isdnldldmd
      361 qlekrsrasg ssagsmkhkr lsrhstashs sshtsgiead tkprdtgped sysssaihrk
      421 lktcssmtsh gsshtsgves ggkdrleedl qddeiemlvd dprdleqmne eslevspdmc
      481 iyitedmlms rklnghsgli vkeigsstss ssetvvklrg qstdslpqti crkpktstdr
      541 hslslddirl yqkdflriag lcqdtaqsyt fgcgheldee glycnsclaq qciniqdafp
      601 vkrtskyfsl dlthdevpef vv
//
LOCUS       XP_047286884             622 aa            linear   PRI 05-AUG-2025
DEFINITION  FERM domain-containing protein 6 isoform X1 [Homo sapiens].
ACCESSION   XP_047286884
VERSION     XP_047286884.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430928.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..622
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..622
                     /product="FERM domain-containing protein 6 isoform X1"
                     /calculated_mol_wt=71913
     Region          15..120
                     /region_name="FERM_F1_FRMD6"
                     /note="FERM (Four.1 protein, Ezrin, Radixin, Moesin)
                     domain, F1 sub-domain, found in FERM domain-containing
                     protein 6 (FRMD6); cd17198"
                     /db_xref="CDD:340718"
     Region          118..234
                     /region_name="FERM_M"
                     /note="FERM central domain; pfam00373"
                     /db_xref="CDD:459788"
     Region          227..335
                     /region_name="FERM_C_FRMD1_FRMD6"
                     /note="FERM domain C-lobe of FERM domain containing 1 and
                     6 proteins; cd13185"
                     /db_xref="CDD:270006"
     Site            order(241,258,260,270)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:270006"
     Site            order(274,279..282,314,318,321..322)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270006"
     Site            314..325
                     /site_type="other"
                     /note="putative actin binding site 2 [polypeptide
                     binding]"
                     /db_xref="CDD:270006"
     CDS             1..622
                     /gene="FRMD6"
                     /gene_synonym="C14orf31; c14_5320; EX1; Willin"
                     /coded_by="XM_047430928.1:719..2587"
                     /db_xref="GeneID:122786"
                     /db_xref="HGNC:HGNC:19839"
                     /db_xref="MIM:614555"
ORIGIN      
        1 mnklnfhnnr vmqdrrsvci flpndeslni iinvkilchq llvqvcdllr lkdchlfgls
       61 viqnnehvym elsqklykyc pkewkkeask vrqyevtwgi dqfgppmiih frvqyyveng
      121 rlisdraary yyywhlrkqv lhsqcvlree ayfllaafal qadlgnfkrn khygkyfepe
      181 ayfpswvvsk rgkdyilkhi pnmhkdqfal taseahlkyi keavrlddva vhyyrlykdk
      241 reieasltlg ltmrgiqifq nldeekqlly dfpwtnvgkl vfvgkkfeil pdglpsarkl
      301 iyytgcpmrs rhllqllsns hrlymnlqpv lrhirkleen eekkqyresy isdnldldmd
      361 qlekrsrasg ssagsmkhkr lsrhstashs sshtsgiead tkprdtgped sysssaihrk
      421 lktcssmtsh gsshtsgves ggkdrleedl qddeiemlvd dprdleqmne eslevspdmc
      481 iyitedmlms rklnghsgli vkeigsstss ssetvvklrg qstdslpqti crkpktstdr
      541 hslslddirl yqkdflriag lcqdtaqsyt fgcgheldee glycnsclaq qciniqdafp
      601 vkrtskyfsl dlthdevpef vv
//
LOCUS       XP_006720093             614 aa            linear   PRI 05-AUG-2025
DEFINITION  FERM domain-containing protein 6 isoform X2 [Homo sapiens].
ACCESSION   XP_006720093
VERSION     XP_006720093.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720030.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..614
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..614
                     /product="FERM domain-containing protein 6 isoform X2"
                     /calculated_mol_wt=70851
     Region          15..112
                     /region_name="FERM_F1_FRMD6"
                     /note="FERM (Four.1 protein, Ezrin, Radixin, Moesin)
                     domain, F1 sub-domain, found in FERM domain-containing
                     protein 6 (FRMD6); cd17198"
                     /db_xref="CDD:340718"
     Region          20..226
                     /region_name="B41"
                     /note="Band 4.1 homologues; smart00295"
                     /db_xref="CDD:214604"
     Region          219..327
                     /region_name="FERM_C_FRMD1_FRMD6"
                     /note="FERM domain C-lobe of FERM domain containing 1 and
                     6 proteins; cd13185"
                     /db_xref="CDD:270006"
     Site            order(233,250,252,262)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:270006"
     Site            order(266,271..274,306,310,313..314)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270006"
     Site            306..317
                     /site_type="other"
                     /note="putative actin binding site 2 [polypeptide
                     binding]"
                     /db_xref="CDD:270006"
     CDS             1..614
                     /gene="FRMD6"
                     /gene_synonym="C14orf31; c14_5320; EX1; Willin"
                     /coded_by="XM_006720030.2:455..2299"
                     /db_xref="GeneID:122786"
                     /db_xref="HGNC:HGNC:19839"
                     /db_xref="MIM:614555"
ORIGIN      
        1 mnklnfhnnr vmqdrrsvci flpndeslni iinvkilchq llvqvcdllr lkdchlfgls
       61 viqnnehvym elsqklykyc pkewkkeask gidqfgppmi ihfrvqyyve ngrlisdraa
      121 ryyyywhlrk qvlhsqcvlr eeayfllaaf alqadlgnfk rnkhygkyfe peayfpswvv
      181 skrgkdyilk hipnmhkdqf altaseahlk yikeavrldd vavhyyrlyk dkreieaslt
      241 lgltmrgiqi fqnldeekql lydfpwtnvg klvfvgkkfe ilpdglpsar kliyytgcpm
      301 rsrhllqlls nshrlymnlq pvlrhirkle eneekkqyre syisdnldld mdqlekrsra
      361 sgssagsmkh krlsrhstas hssshtsgie adtkprdtgp edsysssaih rklktcssmt
      421 shgsshtsgv esggkdrlee dlqddeieml vddprdleqm neeslevspd mciyitedml
      481 msrklnghsg livkeigsst ssssetvvkl rgqstdslpq ticrkpktst drhslslddi
      541 rlyqkdflri aglcqdtaqs ytfgcgheld eeglycnscl aqqciniqda fpvkrtskyf
      601 sldlthdevp efvv
//
LOCUS       XP_024305244             614 aa            linear   PRI 05-AUG-2025
DEFINITION  FERM domain-containing protein 6 isoform X2 [Homo sapiens].
ACCESSION   XP_024305244
VERSION     XP_024305244.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449476.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..614
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..614
                     /product="FERM domain-containing protein 6 isoform X2"
                     /calculated_mol_wt=70851
     Region          15..112
                     /region_name="FERM_F1_FRMD6"
                     /note="FERM (Four.1 protein, Ezrin, Radixin, Moesin)
                     domain, F1 sub-domain, found in FERM domain-containing
                     protein 6 (FRMD6); cd17198"
                     /db_xref="CDD:340718"
     Region          20..226
                     /region_name="B41"
                     /note="Band 4.1 homologues; smart00295"
                     /db_xref="CDD:214604"
     Region          219..327
                     /region_name="FERM_C_FRMD1_FRMD6"
                     /note="FERM domain C-lobe of FERM domain containing 1 and
                     6 proteins; cd13185"
                     /db_xref="CDD:270006"
     Site            order(233,250,252,262)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:270006"
     Site            order(266,271..274,306,310,313..314)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270006"
     Site            306..317
                     /site_type="other"
                     /note="putative actin binding site 2 [polypeptide
                     binding]"
                     /db_xref="CDD:270006"
     CDS             1..614
                     /gene="FRMD6"
                     /gene_synonym="C14orf31; c14_5320; EX1; Willin"
                     /coded_by="XM_024449476.2:1028..2872"
                     /db_xref="GeneID:122786"
                     /db_xref="HGNC:HGNC:19839"
                     /db_xref="MIM:614555"
ORIGIN      
        1 mnklnfhnnr vmqdrrsvci flpndeslni iinvkilchq llvqvcdllr lkdchlfgls
       61 viqnnehvym elsqklykyc pkewkkeask gidqfgppmi ihfrvqyyve ngrlisdraa
      121 ryyyywhlrk qvlhsqcvlr eeayfllaaf alqadlgnfk rnkhygkyfe peayfpswvv
      181 skrgkdyilk hipnmhkdqf altaseahlk yikeavrldd vavhyyrlyk dkreieaslt
      241 lgltmrgiqi fqnldeekql lydfpwtnvg klvfvgkkfe ilpdglpsar kliyytgcpm
      301 rsrhllqlls nshrlymnlq pvlrhirkle eneekkqyre syisdnldld mdqlekrsra
      361 sgssagsmkh krlsrhstas hssshtsgie adtkprdtgp edsysssaih rklktcssmt
      421 shgsshtsgv esggkdrlee dlqddeieml vddprdleqm neeslevspd mciyitedml
      481 msrklnghsg livkeigsst ssssetvvkl rgqstdslpq ticrkpktst drhslslddi
      541 rlyqkdflri aglcqdtaqs ytfgcgheld eeglycnscl aqqciniqda fpvkrtskyf
      601 sldlthdevp efvv
//
LOCUS       XP_047286885             614 aa            linear   PRI 05-AUG-2025
DEFINITION  FERM domain-containing protein 6 isoform X2 [Homo sapiens].
ACCESSION   XP_047286885
VERSION     XP_047286885.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430929.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..614
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..614
                     /product="FERM domain-containing protein 6 isoform X2"
                     /calculated_mol_wt=70851
     Region          15..112
                     /region_name="FERM_F1_FRMD6"
                     /note="FERM (Four.1 protein, Ezrin, Radixin, Moesin)
                     domain, F1 sub-domain, found in FERM domain-containing
                     protein 6 (FRMD6); cd17198"
                     /db_xref="CDD:340718"
     Region          20..226
                     /region_name="B41"
                     /note="Band 4.1 homologues; smart00295"
                     /db_xref="CDD:214604"
     Region          219..327
                     /region_name="FERM_C_FRMD1_FRMD6"
                     /note="FERM domain C-lobe of FERM domain containing 1 and
                     6 proteins; cd13185"
                     /db_xref="CDD:270006"
     Site            order(233,250,252,262)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:270006"
     Site            order(266,271..274,306,310,313..314)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270006"
     Site            306..317
                     /site_type="other"
                     /note="putative actin binding site 2 [polypeptide
                     binding]"
                     /db_xref="CDD:270006"
     CDS             1..614
                     /gene="FRMD6"
                     /gene_synonym="C14orf31; c14_5320; EX1; Willin"
                     /coded_by="XM_047430929.1:843..2687"
                     /db_xref="GeneID:122786"
                     /db_xref="HGNC:HGNC:19839"
                     /db_xref="MIM:614555"
ORIGIN      
        1 mnklnfhnnr vmqdrrsvci flpndeslni iinvkilchq llvqvcdllr lkdchlfgls
       61 viqnnehvym elsqklykyc pkewkkeask gidqfgppmi ihfrvqyyve ngrlisdraa
      121 ryyyywhlrk qvlhsqcvlr eeayfllaaf alqadlgnfk rnkhygkyfe peayfpswvv
      181 skrgkdyilk hipnmhkdqf altaseahlk yikeavrldd vavhyyrlyk dkreieaslt
      241 lgltmrgiqi fqnldeekql lydfpwtnvg klvfvgkkfe ilpdglpsar kliyytgcpm
      301 rsrhllqlls nshrlymnlq pvlrhirkle eneekkqyre syisdnldld mdqlekrsra
      361 sgssagsmkh krlsrhstas hssshtsgie adtkprdtgp edsysssaih rklktcssmt
      421 shgsshtsgv esggkdrlee dlqddeieml vddprdleqm neeslevspd mciyitedml
      481 msrklnghsg livkeigsst ssssetvvkl rgqstdslpq ticrkpktst drhslslddi
      541 rlyqkdflri aglcqdtaqs ytfgcgheld eeglycnscl aqqciniqda fpvkrtskyf
      601 sldlthdevp efvv
//
LOCUS       XP_047286886             614 aa            linear   PRI 05-AUG-2025
DEFINITION  FERM domain-containing protein 6 isoform X2 [Homo sapiens].
ACCESSION   XP_047286886
VERSION     XP_047286886.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430930.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..614
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..614
                     /product="FERM domain-containing protein 6 isoform X2"
                     /calculated_mol_wt=70851
     Region          15..112
                     /region_name="FERM_F1_FRMD6"
                     /note="FERM (Four.1 protein, Ezrin, Radixin, Moesin)
                     domain, F1 sub-domain, found in FERM domain-containing
                     protein 6 (FRMD6); cd17198"
                     /db_xref="CDD:340718"
     Region          20..226
                     /region_name="B41"
                     /note="Band 4.1 homologues; smart00295"
                     /db_xref="CDD:214604"
     Region          219..327
                     /region_name="FERM_C_FRMD1_FRMD6"
                     /note="FERM domain C-lobe of FERM domain containing 1 and
                     6 proteins; cd13185"
                     /db_xref="CDD:270006"
     Site            order(233,250,252,262)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:270006"
     Site            order(266,271..274,306,310,313..314)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270006"
     Site            306..317
                     /site_type="other"
                     /note="putative actin binding site 2 [polypeptide
                     binding]"
                     /db_xref="CDD:270006"
     CDS             1..614
                     /gene="FRMD6"
                     /gene_synonym="C14orf31; c14_5320; EX1; Willin"
                     /coded_by="XM_047430930.1:1104..2948"
                     /db_xref="GeneID:122786"
                     /db_xref="HGNC:HGNC:19839"
                     /db_xref="MIM:614555"
ORIGIN      
        1 mnklnfhnnr vmqdrrsvci flpndeslni iinvkilchq llvqvcdllr lkdchlfgls
       61 viqnnehvym elsqklykyc pkewkkeask gidqfgppmi ihfrvqyyve ngrlisdraa
      121 ryyyywhlrk qvlhsqcvlr eeayfllaaf alqadlgnfk rnkhygkyfe peayfpswvv
      181 skrgkdyilk hipnmhkdqf altaseahlk yikeavrldd vavhyyrlyk dkreieaslt
      241 lgltmrgiqi fqnldeekql lydfpwtnvg klvfvgkkfe ilpdglpsar kliyytgcpm
      301 rsrhllqlls nshrlymnlq pvlrhirkle eneekkqyre syisdnldld mdqlekrsra
      361 sgssagsmkh krlsrhstas hssshtsgie adtkprdtgp edsysssaih rklktcssmt
      421 shgsshtsgv esggkdrlee dlqddeieml vddprdleqm neeslevspd mciyitedml
      481 msrklnghsg livkeigsst ssssetvvkl rgqstdslpq ticrkpktst drhslslddi
      541 rlyqkdflri aglcqdtaqs ytfgcgheld eeglycnscl aqqciniqda fpvkrtskyf
      601 sldlthdevp efvv
//
LOCUS       XP_047286887             614 aa            linear   PRI 05-AUG-2025
DEFINITION  FERM domain-containing protein 6 isoform X2 [Homo sapiens].
ACCESSION   XP_047286887
VERSION     XP_047286887.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430931.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..614
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..614
                     /product="FERM domain-containing protein 6 isoform X2"
                     /calculated_mol_wt=70851
     Region          15..112
                     /region_name="FERM_F1_FRMD6"
                     /note="FERM (Four.1 protein, Ezrin, Radixin, Moesin)
                     domain, F1 sub-domain, found in FERM domain-containing
                     protein 6 (FRMD6); cd17198"
                     /db_xref="CDD:340718"
     Region          20..226
                     /region_name="B41"
                     /note="Band 4.1 homologues; smart00295"
                     /db_xref="CDD:214604"
     Region          219..327
                     /region_name="FERM_C_FRMD1_FRMD6"
                     /note="FERM domain C-lobe of FERM domain containing 1 and
                     6 proteins; cd13185"
                     /db_xref="CDD:270006"
     Site            order(233,250,252,262)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:270006"
     Site            order(266,271..274,306,310,313..314)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270006"
     Site            306..317
                     /site_type="other"
                     /note="putative actin binding site 2 [polypeptide
                     binding]"
                     /db_xref="CDD:270006"
     CDS             1..614
                     /gene="FRMD6"
                     /gene_synonym="C14orf31; c14_5320; EX1; Willin"
                     /coded_by="XM_047430931.1:658..2502"
                     /db_xref="GeneID:122786"
                     /db_xref="HGNC:HGNC:19839"
                     /db_xref="MIM:614555"
ORIGIN      
        1 mnklnfhnnr vmqdrrsvci flpndeslni iinvkilchq llvqvcdllr lkdchlfgls
       61 viqnnehvym elsqklykyc pkewkkeask gidqfgppmi ihfrvqyyve ngrlisdraa
      121 ryyyywhlrk qvlhsqcvlr eeayfllaaf alqadlgnfk rnkhygkyfe peayfpswvv
      181 skrgkdyilk hipnmhkdqf altaseahlk yikeavrldd vavhyyrlyk dkreieaslt
      241 lgltmrgiqi fqnldeekql lydfpwtnvg klvfvgkkfe ilpdglpsar kliyytgcpm
      301 rsrhllqlls nshrlymnlq pvlrhirkle eneekkqyre syisdnldld mdqlekrsra
      361 sgssagsmkh krlsrhstas hssshtsgie adtkprdtgp edsysssaih rklktcssmt
      421 shgsshtsgv esggkdrlee dlqddeieml vddprdleqm neeslevspd mciyitedml
      481 msrklnghsg livkeigsst ssssetvvkl rgqstdslpq ticrkpktst drhslslddi
      541 rlyqkdflri aglcqdtaqs ytfgcgheld eeglycnscl aqqciniqda fpvkrtskyf
      601 sldlthdevp efvv
//
LOCUS       XP_047286888             614 aa            linear   PRI 05-AUG-2025
DEFINITION  FERM domain-containing protein 6 isoform X2 [Homo sapiens].
ACCESSION   XP_047286888
VERSION     XP_047286888.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430932.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..614
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..614
                     /product="FERM domain-containing protein 6 isoform X2"
                     /calculated_mol_wt=70851
     Region          15..112
                     /region_name="FERM_F1_FRMD6"
                     /note="FERM (Four.1 protein, Ezrin, Radixin, Moesin)
                     domain, F1 sub-domain, found in FERM domain-containing
                     protein 6 (FRMD6); cd17198"
                     /db_xref="CDD:340718"
     Region          20..226
                     /region_name="B41"
                     /note="Band 4.1 homologues; smart00295"
                     /db_xref="CDD:214604"
     Region          219..327
                     /region_name="FERM_C_FRMD1_FRMD6"
                     /note="FERM domain C-lobe of FERM domain containing 1 and
                     6 proteins; cd13185"
                     /db_xref="CDD:270006"
     Site            order(233,250,252,262)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:270006"
     Site            order(266,271..274,306,310,313..314)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270006"
     Site            306..317
                     /site_type="other"
                     /note="putative actin binding site 2 [polypeptide
                     binding]"
                     /db_xref="CDD:270006"
     CDS             1..614
                     /gene="FRMD6"
                     /gene_synonym="C14orf31; c14_5320; EX1; Willin"
                     /coded_by="XM_047430932.1:627..2471"
                     /db_xref="GeneID:122786"
                     /db_xref="HGNC:HGNC:19839"
                     /db_xref="MIM:614555"
ORIGIN      
        1 mnklnfhnnr vmqdrrsvci flpndeslni iinvkilchq llvqvcdllr lkdchlfgls
       61 viqnnehvym elsqklykyc pkewkkeask gidqfgppmi ihfrvqyyve ngrlisdraa
      121 ryyyywhlrk qvlhsqcvlr eeayfllaaf alqadlgnfk rnkhygkyfe peayfpswvv
      181 skrgkdyilk hipnmhkdqf altaseahlk yikeavrldd vavhyyrlyk dkreieaslt
      241 lgltmrgiqi fqnldeekql lydfpwtnvg klvfvgkkfe ilpdglpsar kliyytgcpm
      301 rsrhllqlls nshrlymnlq pvlrhirkle eneekkqyre syisdnldld mdqlekrsra
      361 sgssagsmkh krlsrhstas hssshtsgie adtkprdtgp edsysssaih rklktcssmt
      421 shgsshtsgv esggkdrlee dlqddeieml vddprdleqm neeslevspd mciyitedml
      481 msrklnghsg livkeigsst ssssetvvkl rgqstdslpq ticrkpktst drhslslddi
      541 rlyqkdflri aglcqdtaqs ytfgcgheld eeglycnscl aqqciniqda fpvkrtskyf
      601 sldlthdevp efvv
//
LOCUS       XP_047286889             614 aa            linear   PRI 05-AUG-2025
DEFINITION  FERM domain-containing protein 6 isoform X2 [Homo sapiens].
ACCESSION   XP_047286889
VERSION     XP_047286889.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430933.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..614
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..614
                     /product="FERM domain-containing protein 6 isoform X2"
                     /calculated_mol_wt=70851
     Region          15..112
                     /region_name="FERM_F1_FRMD6"
                     /note="FERM (Four.1 protein, Ezrin, Radixin, Moesin)
                     domain, F1 sub-domain, found in FERM domain-containing
                     protein 6 (FRMD6); cd17198"
                     /db_xref="CDD:340718"
     Region          20..226
                     /region_name="B41"
                     /note="Band 4.1 homologues; smart00295"
                     /db_xref="CDD:214604"
     Region          219..327
                     /region_name="FERM_C_FRMD1_FRMD6"
                     /note="FERM domain C-lobe of FERM domain containing 1 and
                     6 proteins; cd13185"
                     /db_xref="CDD:270006"
     Site            order(233,250,252,262)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:270006"
     Site            order(266,271..274,306,310,313..314)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270006"
     Site            306..317
                     /site_type="other"
                     /note="putative actin binding site 2 [polypeptide
                     binding]"
                     /db_xref="CDD:270006"
     CDS             1..614
                     /gene="FRMD6"
                     /gene_synonym="C14orf31; c14_5320; EX1; Willin"
                     /coded_by="XM_047430933.1:946..2790"
                     /db_xref="GeneID:122786"
                     /db_xref="HGNC:HGNC:19839"
                     /db_xref="MIM:614555"
ORIGIN      
        1 mnklnfhnnr vmqdrrsvci flpndeslni iinvkilchq llvqvcdllr lkdchlfgls
       61 viqnnehvym elsqklykyc pkewkkeask gidqfgppmi ihfrvqyyve ngrlisdraa
      121 ryyyywhlrk qvlhsqcvlr eeayfllaaf alqadlgnfk rnkhygkyfe peayfpswvv
      181 skrgkdyilk hipnmhkdqf altaseahlk yikeavrldd vavhyyrlyk dkreieaslt
      241 lgltmrgiqi fqnldeekql lydfpwtnvg klvfvgkkfe ilpdglpsar kliyytgcpm
      301 rsrhllqlls nshrlymnlq pvlrhirkle eneekkqyre syisdnldld mdqlekrsra
      361 sgssagsmkh krlsrhstas hssshtsgie adtkprdtgp edsysssaih rklktcssmt
      421 shgsshtsgv esggkdrlee dlqddeieml vddprdleqm neeslevspd mciyitedml
      481 msrklnghsg livkeigsst ssssetvvkl rgqstdslpq ticrkpktst drhslslddi
      541 rlyqkdflri aglcqdtaqs ytfgcgheld eeglycnscl aqqciniqda fpvkrtskyf
      601 sldlthdevp efvv
//
LOCUS       XP_047286890             614 aa            linear   PRI 05-AUG-2025
DEFINITION  FERM domain-containing protein 6 isoform X2 [Homo sapiens].
ACCESSION   XP_047286890
VERSION     XP_047286890.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430934.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..614
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..614
                     /product="FERM domain-containing protein 6 isoform X2"
                     /calculated_mol_wt=70851
     Region          15..112
                     /region_name="FERM_F1_FRMD6"
                     /note="FERM (Four.1 protein, Ezrin, Radixin, Moesin)
                     domain, F1 sub-domain, found in FERM domain-containing
                     protein 6 (FRMD6); cd17198"
                     /db_xref="CDD:340718"
     Region          20..226
                     /region_name="B41"
                     /note="Band 4.1 homologues; smart00295"
                     /db_xref="CDD:214604"
     Region          219..327
                     /region_name="FERM_C_FRMD1_FRMD6"
                     /note="FERM domain C-lobe of FERM domain containing 1 and
                     6 proteins; cd13185"
                     /db_xref="CDD:270006"
     Site            order(233,250,252,262)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:270006"
     Site            order(266,271..274,306,310,313..314)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270006"
     Site            306..317
                     /site_type="other"
                     /note="putative actin binding site 2 [polypeptide
                     binding]"
                     /db_xref="CDD:270006"
     CDS             1..614
                     /gene="FRMD6"
                     /gene_synonym="C14orf31; c14_5320; EX1; Willin"
                     /coded_by="XM_047430934.1:462..2306"
                     /db_xref="GeneID:122786"
                     /db_xref="HGNC:HGNC:19839"
                     /db_xref="MIM:614555"
ORIGIN      
        1 mnklnfhnnr vmqdrrsvci flpndeslni iinvkilchq llvqvcdllr lkdchlfgls
       61 viqnnehvym elsqklykyc pkewkkeask gidqfgppmi ihfrvqyyve ngrlisdraa
      121 ryyyywhlrk qvlhsqcvlr eeayfllaaf alqadlgnfk rnkhygkyfe peayfpswvv
      181 skrgkdyilk hipnmhkdqf altaseahlk yikeavrldd vavhyyrlyk dkreieaslt
      241 lgltmrgiqi fqnldeekql lydfpwtnvg klvfvgkkfe ilpdglpsar kliyytgcpm
      301 rsrhllqlls nshrlymnlq pvlrhirkle eneekkqyre syisdnldld mdqlekrsra
      361 sgssagsmkh krlsrhstas hssshtsgie adtkprdtgp edsysssaih rklktcssmt
      421 shgsshtsgv esggkdrlee dlqddeieml vddprdleqm neeslevspd mciyitedml
      481 msrklnghsg livkeigsst ssssetvvkl rgqstdslpq ticrkpktst drhslslddi
      541 rlyqkdflri aglcqdtaqs ytfgcgheld eeglycnscl aqqciniqda fpvkrtskyf
      601 sldlthdevp efvv
//
LOCUS       XP_047286891             614 aa            linear   PRI 05-AUG-2025
DEFINITION  FERM domain-containing protein 6 isoform X2 [Homo sapiens].
ACCESSION   XP_047286891
VERSION     XP_047286891.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430935.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..614
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..614
                     /product="FERM domain-containing protein 6 isoform X2"
                     /calculated_mol_wt=70851
     Region          15..112
                     /region_name="FERM_F1_FRMD6"
                     /note="FERM (Four.1 protein, Ezrin, Radixin, Moesin)
                     domain, F1 sub-domain, found in FERM domain-containing
                     protein 6 (FRMD6); cd17198"
                     /db_xref="CDD:340718"
     Region          20..226
                     /region_name="B41"
                     /note="Band 4.1 homologues; smart00295"
                     /db_xref="CDD:214604"
     Region          219..327
                     /region_name="FERM_C_FRMD1_FRMD6"
                     /note="FERM domain C-lobe of FERM domain containing 1 and
                     6 proteins; cd13185"
                     /db_xref="CDD:270006"
     Site            order(233,250,252,262)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:270006"
     Site            order(266,271..274,306,310,313..314)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270006"
     Site            306..317
                     /site_type="other"
                     /note="putative actin binding site 2 [polypeptide
                     binding]"
                     /db_xref="CDD:270006"
     CDS             1..614
                     /gene="FRMD6"
                     /gene_synonym="C14orf31; c14_5320; EX1; Willin"
                     /coded_by="XM_047430935.1:5298..7142"
                     /db_xref="GeneID:122786"
                     /db_xref="HGNC:HGNC:19839"
                     /db_xref="MIM:614555"
ORIGIN      
        1 mnklnfhnnr vmqdrrsvci flpndeslni iinvkilchq llvqvcdllr lkdchlfgls
       61 viqnnehvym elsqklykyc pkewkkeask gidqfgppmi ihfrvqyyve ngrlisdraa
      121 ryyyywhlrk qvlhsqcvlr eeayfllaaf alqadlgnfk rnkhygkyfe peayfpswvv
      181 skrgkdyilk hipnmhkdqf altaseahlk yikeavrldd vavhyyrlyk dkreieaslt
      241 lgltmrgiqi fqnldeekql lydfpwtnvg klvfvgkkfe ilpdglpsar kliyytgcpm
      301 rsrhllqlls nshrlymnlq pvlrhirkle eneekkqyre syisdnldld mdqlekrsra
      361 sgssagsmkh krlsrhstas hssshtsgie adtkprdtgp edsysssaih rklktcssmt
      421 shgsshtsgv esggkdrlee dlqddeieml vddprdleqm neeslevspd mciyitedml
      481 msrklnghsg livkeigsst ssssetvvkl rgqstdslpq ticrkpktst drhslslddi
      541 rlyqkdflri aglcqdtaqs ytfgcgheld eeglycnscl aqqciniqda fpvkrtskyf
      601 sldlthdevp efvv
//
LOCUS       XP_047286892             538 aa            linear   PRI 05-AUG-2025
DEFINITION  FERM domain-containing protein 6 isoform X3 [Homo sapiens].
ACCESSION   XP_047286892
VERSION     XP_047286892.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430936.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..538
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..538
                     /product="FERM domain-containing protein 6 isoform X3"
                     /calculated_mol_wt=62431
     Region          15..120
                     /region_name="FERM_F1_FRMD6"
                     /note="FERM (Four.1 protein, Ezrin, Radixin, Moesin)
                     domain, F1 sub-domain, found in FERM domain-containing
                     protein 6 (FRMD6); cd17198"
                     /db_xref="CDD:340718"
     Region          118..234
                     /region_name="FERM_M"
                     /note="FERM central domain; pfam00373"
                     /db_xref="CDD:459788"
     Region          227..335
                     /region_name="FERM_C_FRMD1_FRMD6"
                     /note="FERM domain C-lobe of FERM domain containing 1 and
                     6 proteins; cd13185"
                     /db_xref="CDD:270006"
     Site            order(241,258,260,270)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:270006"
     Site            order(274,279..282,314,318,321..322)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270006"
     Site            314..325
                     /site_type="other"
                     /note="putative actin binding site 2 [polypeptide
                     binding]"
                     /db_xref="CDD:270006"
     CDS             1..538
                     /gene="FRMD6"
                     /gene_synonym="C14orf31; c14_5320; EX1; Willin"
                     /coded_by="XM_047430936.1:234..1850"
                     /db_xref="GeneID:122786"
                     /db_xref="HGNC:HGNC:19839"
                     /db_xref="MIM:614555"
ORIGIN      
        1 mnklnfhnnr vmqdrrsvci flpndeslni iinvkilchq llvqvcdllr lkdchlfgls
       61 viqnnehvym elsqklykyc pkewkkeask vrqyevtwgi dqfgppmiih frvqyyveng
      121 rlisdraary yyywhlrkqv lhsqcvlree ayfllaafal qadlgnfkrn khygkyfepe
      181 ayfpswvvsk rgkdyilkhi pnmhkdqfal taseahlkyi keavrlddva vhyyrlykdk
      241 reieasltlg ltmrgiqifq nldeekqlly dfpwtnvgkl vfvgkkfeil pdglpsarkl
      301 iyytgcpmrs rhllqllsns hrlymnlqpv lrhirkleen eekkqyresy isdnldldmd
      361 qlekrsrasg ssagsmkhkr lsrhstashs sshtsgiead tkprdtgped sysssaihrk
      421 lktcssmtsh gsshtsgves ggkdrleedl qddeiemlvd dprdleqmne eslevspdmc
      481 iyitedmlms rklnghsgli vkeigsstss ssetvvklrg qstdslpqpr nhrlettf
//
LOCUS       XP_016876456             538 aa            linear   PRI 05-AUG-2025
DEFINITION  FERM domain-containing protein 6 isoform X3 [Homo sapiens].
ACCESSION   XP_016876456
VERSION     XP_016876456.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020967.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..538
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..538
                     /product="FERM domain-containing protein 6 isoform X3"
                     /calculated_mol_wt=62431
     Region          15..120
                     /region_name="FERM_F1_FRMD6"
                     /note="FERM (Four.1 protein, Ezrin, Radixin, Moesin)
                     domain, F1 sub-domain, found in FERM domain-containing
                     protein 6 (FRMD6); cd17198"
                     /db_xref="CDD:340718"
     Region          118..234
                     /region_name="FERM_M"
                     /note="FERM central domain; pfam00373"
                     /db_xref="CDD:459788"
     Region          227..335
                     /region_name="FERM_C_FRMD1_FRMD6"
                     /note="FERM domain C-lobe of FERM domain containing 1 and
                     6 proteins; cd13185"
                     /db_xref="CDD:270006"
     Site            order(241,258,260,270)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:270006"
     Site            order(274,279..282,314,318,321..322)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270006"
     Site            314..325
                     /site_type="other"
                     /note="putative actin binding site 2 [polypeptide
                     binding]"
                     /db_xref="CDD:270006"
     CDS             1..538
                     /gene="FRMD6"
                     /gene_synonym="C14orf31; c14_5320; EX1; Willin"
                     /coded_by="XM_017020967.2:234..1850"
                     /db_xref="GeneID:122786"
                     /db_xref="HGNC:HGNC:19839"
                     /db_xref="MIM:614555"
ORIGIN      
        1 mnklnfhnnr vmqdrrsvci flpndeslni iinvkilchq llvqvcdllr lkdchlfgls
       61 viqnnehvym elsqklykyc pkewkkeask vrqyevtwgi dqfgppmiih frvqyyveng
      121 rlisdraary yyywhlrkqv lhsqcvlree ayfllaafal qadlgnfkrn khygkyfepe
      181 ayfpswvvsk rgkdyilkhi pnmhkdqfal taseahlkyi keavrlddva vhyyrlykdk
      241 reieasltlg ltmrgiqifq nldeekqlly dfpwtnvgkl vfvgkkfeil pdglpsarkl
      301 iyytgcpmrs rhllqllsns hrlymnlqpv lrhirkleen eekkqyresy isdnldldmd
      361 qlekrsrasg ssagsmkhkr lsrhstashs sshtsgiead tkprdtgped sysssaihrk
      421 lktcssmtsh gsshtsgves ggkdrleedl qddeiemlvd dprdleqmne eslevspdmc
      481 iyitedmlms rklnghsgli vkeigsstss ssetvvklrg qstdslpqpr nhrlettf
//
LOCUS       XP_016876457             530 aa            linear   PRI 05-AUG-2025
DEFINITION  FERM domain-containing protein 6 isoform X4 [Homo sapiens].
ACCESSION   XP_016876457
VERSION     XP_016876457.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020968.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..530
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..530
                     /product="FERM domain-containing protein 6 isoform X4"
                     /calculated_mol_wt=61369
     Region          15..112
                     /region_name="FERM_F1_FRMD6"
                     /note="FERM (Four.1 protein, Ezrin, Radixin, Moesin)
                     domain, F1 sub-domain, found in FERM domain-containing
                     protein 6 (FRMD6); cd17198"
                     /db_xref="CDD:340718"
     Region          20..226
                     /region_name="B41"
                     /note="Band 4.1 homologues; smart00295"
                     /db_xref="CDD:214604"
     Region          219..327
                     /region_name="FERM_C_FRMD1_FRMD6"
                     /note="FERM domain C-lobe of FERM domain containing 1 and
                     6 proteins; cd13185"
                     /db_xref="CDD:270006"
     Site            order(233,250,252,262)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:270006"
     Site            order(266,271..274,306,310,313..314)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270006"
     Site            306..317
                     /site_type="other"
                     /note="putative actin binding site 2 [polypeptide
                     binding]"
                     /db_xref="CDD:270006"
     CDS             1..530
                     /gene="FRMD6"
                     /gene_synonym="C14orf31; c14_5320; EX1; Willin"
                     /coded_by="XM_017020968.3:234..1826"
                     /db_xref="GeneID:122786"
                     /db_xref="HGNC:HGNC:19839"
                     /db_xref="MIM:614555"
ORIGIN      
        1 mnklnfhnnr vmqdrrsvci flpndeslni iinvkilchq llvqvcdllr lkdchlfgls
       61 viqnnehvym elsqklykyc pkewkkeask gidqfgppmi ihfrvqyyve ngrlisdraa
      121 ryyyywhlrk qvlhsqcvlr eeayfllaaf alqadlgnfk rnkhygkyfe peayfpswvv
      181 skrgkdyilk hipnmhkdqf altaseahlk yikeavrldd vavhyyrlyk dkreieaslt
      241 lgltmrgiqi fqnldeekql lydfpwtnvg klvfvgkkfe ilpdglpsar kliyytgcpm
      301 rsrhllqlls nshrlymnlq pvlrhirkle eneekkqyre syisdnldld mdqlekrsra
      361 sgssagsmkh krlsrhstas hssshtsgie adtkprdtgp edsysssaih rklktcssmt
      421 shgsshtsgv esggkdrlee dlqddeieml vddprdleqm neeslevspd mciyitedml
      481 msrklnghsg livkeigsst ssssetvvkl rgqstdslpq prnhrlettf
//
LOCUS       XP_047286893             530 aa            linear   PRI 05-AUG-2025
DEFINITION  FERM domain-containing protein 6 isoform X4 [Homo sapiens].
ACCESSION   XP_047286893
VERSION     XP_047286893.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430937.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..530
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..530
                     /product="FERM domain-containing protein 6 isoform X4"
                     /calculated_mol_wt=61369
     Region          15..112
                     /region_name="FERM_F1_FRMD6"
                     /note="FERM (Four.1 protein, Ezrin, Radixin, Moesin)
                     domain, F1 sub-domain, found in FERM domain-containing
                     protein 6 (FRMD6); cd17198"
                     /db_xref="CDD:340718"
     Region          20..226
                     /region_name="B41"
                     /note="Band 4.1 homologues; smart00295"
                     /db_xref="CDD:214604"
     Region          219..327
                     /region_name="FERM_C_FRMD1_FRMD6"
                     /note="FERM domain C-lobe of FERM domain containing 1 and
                     6 proteins; cd13185"
                     /db_xref="CDD:270006"
     Site            order(233,250,252,262)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:270006"
     Site            order(266,271..274,306,310,313..314)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270006"
     Site            306..317
                     /site_type="other"
                     /note="putative actin binding site 2 [polypeptide
                     binding]"
                     /db_xref="CDD:270006"
     CDS             1..530
                     /gene="FRMD6"
                     /gene_synonym="C14orf31; c14_5320; EX1; Willin"
                     /coded_by="XM_047430937.1:234..1826"
                     /db_xref="GeneID:122786"
                     /db_xref="HGNC:HGNC:19839"
                     /db_xref="MIM:614555"
ORIGIN      
        1 mnklnfhnnr vmqdrrsvci flpndeslni iinvkilchq llvqvcdllr lkdchlfgls
       61 viqnnehvym elsqklykyc pkewkkeask gidqfgppmi ihfrvqyyve ngrlisdraa
      121 ryyyywhlrk qvlhsqcvlr eeayfllaaf alqadlgnfk rnkhygkyfe peayfpswvv
      181 skrgkdyilk hipnmhkdqf altaseahlk yikeavrldd vavhyyrlyk dkreieaslt
      241 lgltmrgiqi fqnldeekql lydfpwtnvg klvfvgkkfe ilpdglpsar kliyytgcpm
      301 rsrhllqlls nshrlymnlq pvlrhirkle eneekkqyre syisdnldld mdqlekrsra
      361 sgssagsmkh krlsrhstas hssshtsgie adtkprdtgp edsysssaih rklktcssmt
      421 shgsshtsgv esggkdrlee dlqddeieml vddprdleqm neeslevspd mciyitedml
      481 msrklnghsg livkeigsst ssssetvvkl rgqstdslpq prnhrlettf
//
LOCUS       XP_047286894             530 aa            linear   PRI 05-AUG-2025
DEFINITION  FERM domain-containing protein 6 isoform X4 [Homo sapiens].
ACCESSION   XP_047286894
VERSION     XP_047286894.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430938.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..530
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..530
                     /product="FERM domain-containing protein 6 isoform X4"
                     /calculated_mol_wt=61369
     Region          15..112
                     /region_name="FERM_F1_FRMD6"
                     /note="FERM (Four.1 protein, Ezrin, Radixin, Moesin)
                     domain, F1 sub-domain, found in FERM domain-containing
                     protein 6 (FRMD6); cd17198"
                     /db_xref="CDD:340718"
     Region          20..226
                     /region_name="B41"
                     /note="Band 4.1 homologues; smart00295"
                     /db_xref="CDD:214604"
     Region          219..327
                     /region_name="FERM_C_FRMD1_FRMD6"
                     /note="FERM domain C-lobe of FERM domain containing 1 and
                     6 proteins; cd13185"
                     /db_xref="CDD:270006"
     Site            order(233,250,252,262)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:270006"
     Site            order(266,271..274,306,310,313..314)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270006"
     Site            306..317
                     /site_type="other"
                     /note="putative actin binding site 2 [polypeptide
                     binding]"
                     /db_xref="CDD:270006"
     CDS             1..530
                     /gene="FRMD6"
                     /gene_synonym="C14orf31; c14_5320; EX1; Willin"
                     /coded_by="XM_047430938.1:455..2047"
                     /db_xref="GeneID:122786"
                     /db_xref="HGNC:HGNC:19839"
                     /db_xref="MIM:614555"
ORIGIN      
        1 mnklnfhnnr vmqdrrsvci flpndeslni iinvkilchq llvqvcdllr lkdchlfgls
       61 viqnnehvym elsqklykyc pkewkkeask gidqfgppmi ihfrvqyyve ngrlisdraa
      121 ryyyywhlrk qvlhsqcvlr eeayfllaaf alqadlgnfk rnkhygkyfe peayfpswvv
      181 skrgkdyilk hipnmhkdqf altaseahlk yikeavrldd vavhyyrlyk dkreieaslt
      241 lgltmrgiqi fqnldeekql lydfpwtnvg klvfvgkkfe ilpdglpsar kliyytgcpm
      301 rsrhllqlls nshrlymnlq pvlrhirkle eneekkqyre syisdnldld mdqlekrsra
      361 sgssagsmkh krlsrhstas hssshtsgie adtkprdtgp edsysssaih rklktcssmt
      421 shgsshtsgv esggkdrlee dlqddeieml vddprdleqm neeslevspd mciyitedml
      481 msrklnghsg livkeigsst ssssetvvkl rgqstdslpq prnhrlettf
//
LOCUS       XP_047286895             530 aa            linear   PRI 05-AUG-2025
DEFINITION  FERM domain-containing protein 6 isoform X4 [Homo sapiens].
ACCESSION   XP_047286895
VERSION     XP_047286895.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430939.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..530
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..530
                     /product="FERM domain-containing protein 6 isoform X4"
                     /calculated_mol_wt=61369
     Region          15..112
                     /region_name="FERM_F1_FRMD6"
                     /note="FERM (Four.1 protein, Ezrin, Radixin, Moesin)
                     domain, F1 sub-domain, found in FERM domain-containing
                     protein 6 (FRMD6); cd17198"
                     /db_xref="CDD:340718"
     Region          20..226
                     /region_name="B41"
                     /note="Band 4.1 homologues; smart00295"
                     /db_xref="CDD:214604"
     Region          219..327
                     /region_name="FERM_C_FRMD1_FRMD6"
                     /note="FERM domain C-lobe of FERM domain containing 1 and
                     6 proteins; cd13185"
                     /db_xref="CDD:270006"
     Site            order(233,250,252,262)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:270006"
     Site            order(266,271..274,306,310,313..314)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270006"
     Site            306..317
                     /site_type="other"
                     /note="putative actin binding site 2 [polypeptide
                     binding]"
                     /db_xref="CDD:270006"
     CDS             1..530
                     /gene="FRMD6"
                     /gene_synonym="C14orf31; c14_5320; EX1; Willin"
                     /coded_by="XM_047430939.1:543..2135"
                     /db_xref="GeneID:122786"
                     /db_xref="HGNC:HGNC:19839"
                     /db_xref="MIM:614555"
ORIGIN      
        1 mnklnfhnnr vmqdrrsvci flpndeslni iinvkilchq llvqvcdllr lkdchlfgls
       61 viqnnehvym elsqklykyc pkewkkeask gidqfgppmi ihfrvqyyve ngrlisdraa
      121 ryyyywhlrk qvlhsqcvlr eeayfllaaf alqadlgnfk rnkhygkyfe peayfpswvv
      181 skrgkdyilk hipnmhkdqf altaseahlk yikeavrldd vavhyyrlyk dkreieaslt
      241 lgltmrgiqi fqnldeekql lydfpwtnvg klvfvgkkfe ilpdglpsar kliyytgcpm
      301 rsrhllqlls nshrlymnlq pvlrhirkle eneekkqyre syisdnldld mdqlekrsra
      361 sgssagsmkh krlsrhstas hssshtsgie adtkprdtgp edsysssaih rklktcssmt
      421 shgsshtsgv esggkdrlee dlqddeieml vddprdleqm neeslevspd mciyitedml
      481 msrklnghsg livkeigsst ssssetvvkl rgqstdslpq prnhrlettf
//
LOCUS       XP_011534727             440 aa            linear   PRI 05-AUG-2025
DEFINITION  suppressor of cytokine signaling 4 isoform X1 [Homo sapiens].
ACCESSION   XP_011534727
VERSION     XP_011534727.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536425.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..440
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..440
                     /product="suppressor of cytokine signaling 4 isoform X1"
                     /calculated_mol_wt=50492
     Region          58..111
                     /region_name="SOCS"
                     /note="Suppressor of cytokine signalling; pfam12610"
                     /db_xref="CDD:432667"
     Region          275..375
                     /region_name="SH2_SOCS4"
                     /note="Src homology 2 (SH2) domain found in suppressor of
                     cytokine signaling (SOCS) proteins; cd10385"
                     /db_xref="CDD:198248"
     Site            order(283,285)
                     /site_type="other"
                     /note="Elongin-C binding interface [polypeptide binding]"
                     /db_xref="CDD:198248"
     Site            order(293,311,313,321,334)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198248"
     Site            order(344,346,364)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198248"
     Region          384..439
                     /region_name="SOCS_SOCS4"
                     /note="SOCS (suppressors of cytokine signaling) box of
                     SOCS4-like proteins. Together with CIS1, the CIS/SOCS
                     family of proteins is characterized by the presence of a
                     C-terminal SOCS box and a central SH2 domain. The general
                     function of the SOCS box is the...; cd03738"
                     /db_xref="CDD:239707"
     Site            order(385..390,396,403,409,414)
                     /site_type="other"
                     /note="putative elongin B/C interaction [polypeptide
                     binding]"
                     /db_xref="CDD:239707"
     CDS             1..440
                     /gene="SOCS4"
                     /gene_synonym="SOCS7"
                     /coded_by="XM_011536425.2:515..1837"
                     /db_xref="GeneID:122809"
                     /db_xref="HGNC:HGNC:19392"
                     /db_xref="MIM:616337"
ORIGIN      
        1 maennenisk nvdvrpktsr srsadrkdgy vwsgkklsws kksesysdae tvngiektev
       61 slrnqerkhs cssieldldh scghrflgrs lkqklqdavg qcfpikncss rhssglpskr
      121 kihiselmld kcpfpprsdl afrwhfikrh tapinsksde wvstdlsqte lrdgqlkrrn
      181 meenincfsh tnvqpcvitt dnalcregpm tgsvmnlvsn nsiedsdmds ddeiltlcts
      241 srkrnkpkwd lddeilqlet ppkyhtqidy vhclvpdllq innnpcywgv mdkyaaeall
      301 egkpegtfll rdsaqedylf svsfrrysrs lharieqwnh nfsfdahdpc vfhspditgl
      361 lehykdpsac mffepllstp lirtfpfslq hicrtvicnc ttydgidalp ipssmklylk
      421 eyhykskvrv lridapeqqc
//
LOCUS       XP_011534728             440 aa            linear   PRI 05-AUG-2025
DEFINITION  suppressor of cytokine signaling 4 isoform X1 [Homo sapiens].
ACCESSION   XP_011534728
VERSION     XP_011534728.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536426.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..440
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..440
                     /product="suppressor of cytokine signaling 4 isoform X1"
                     /calculated_mol_wt=50492
     Region          58..111
                     /region_name="SOCS"
                     /note="Suppressor of cytokine signalling; pfam12610"
                     /db_xref="CDD:432667"
     Region          275..375
                     /region_name="SH2_SOCS4"
                     /note="Src homology 2 (SH2) domain found in suppressor of
                     cytokine signaling (SOCS) proteins; cd10385"
                     /db_xref="CDD:198248"
     Site            order(283,285)
                     /site_type="other"
                     /note="Elongin-C binding interface [polypeptide binding]"
                     /db_xref="CDD:198248"
     Site            order(293,311,313,321,334)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198248"
     Site            order(344,346,364)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198248"
     Region          384..439
                     /region_name="SOCS_SOCS4"
                     /note="SOCS (suppressors of cytokine signaling) box of
                     SOCS4-like proteins. Together with CIS1, the CIS/SOCS
                     family of proteins is characterized by the presence of a
                     C-terminal SOCS box and a central SH2 domain. The general
                     function of the SOCS box is the...; cd03738"
                     /db_xref="CDD:239707"
     Site            order(385..390,396,403,409,414)
                     /site_type="other"
                     /note="putative elongin B/C interaction [polypeptide
                     binding]"
                     /db_xref="CDD:239707"
     CDS             1..440
                     /gene="SOCS4"
                     /gene_synonym="SOCS7"
                     /coded_by="XM_011536426.2:430..1752"
                     /db_xref="GeneID:122809"
                     /db_xref="HGNC:HGNC:19392"
                     /db_xref="MIM:616337"
ORIGIN      
        1 maennenisk nvdvrpktsr srsadrkdgy vwsgkklsws kksesysdae tvngiektev
       61 slrnqerkhs cssieldldh scghrflgrs lkqklqdavg qcfpikncss rhssglpskr
      121 kihiselmld kcpfpprsdl afrwhfikrh tapinsksde wvstdlsqte lrdgqlkrrn
      181 meenincfsh tnvqpcvitt dnalcregpm tgsvmnlvsn nsiedsdmds ddeiltlcts
      241 srkrnkpkwd lddeilqlet ppkyhtqidy vhclvpdllq innnpcywgv mdkyaaeall
      301 egkpegtfll rdsaqedylf svsfrrysrs lharieqwnh nfsfdahdpc vfhspditgl
      361 lehykdpsac mffepllstp lirtfpfslq hicrtvicnc ttydgidalp ipssmklylk
      421 eyhykskvrv lridapeqqc
//
LOCUS       XP_005267387             359 aa            linear   PRI 05-AUG-2025
DEFINITION  NADP-dependent oxidoreductase domain-containing protein 1 isoform
            X1 [Homo sapiens].
ACCESSION   XP_005267387
VERSION     XP_005267387.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267330.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..359
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..359
                     /product="NADP-dependent oxidoreductase domain-containing
                     protein 1 isoform X1"
                     /calculated_mol_wt=39749
     Region          78..>189
                     /region_name="ProC"
                     /note="Pyrroline-5-carboxylate reductase [Amino acid
                     transport and metabolism]; COG0345"
                     /db_xref="CDD:440114"
     CDS             1..359
                     /gene="NOXRED1"
                     /gene_synonym="C14orf148"
                     /coded_by="XM_005267330.5:71..1150"
                     /db_xref="GeneID:122945"
                     /db_xref="HGNC:HGNC:20487"
ORIGIN      
        1 mdmlqdlesl qfeygvpeed riwlylqgrs rglmieacah atffckllyn lraslnknqs
       61 srhlsigsln satpeefkvg iiggghlgkq lagtllqlgp ipaeslrist rrpetlgelq
      121 klgikcfyhn adlvswadvi flcclpsqlp nicveiytsl ekasivysfv aaiplprlkl
      181 llnhtnilrp qyqydedsvs vwgankgvia alqdptilqa tcpyspaggi ilnikwlegv
      241 fyaalnicta rnmahsqvlq llselflsvh fedcgkdtas cpklqltdfv skaygknlsq
      301 erpfpwfdlt avqlketpfs qhlssspvlq dhlthlycas fgisltkeqp vistgfpsq
//
LOCUS       XP_011534730             359 aa            linear   PRI 05-AUG-2025
DEFINITION  NADP-dependent oxidoreductase domain-containing protein 1 isoform
            X1 [Homo sapiens].
ACCESSION   XP_011534730
VERSION     XP_011534730.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536428.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..359
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..359
                     /product="NADP-dependent oxidoreductase domain-containing
                     protein 1 isoform X1"
                     /calculated_mol_wt=39749
     Region          78..>189
                     /region_name="ProC"
                     /note="Pyrroline-5-carboxylate reductase [Amino acid
                     transport and metabolism]; COG0345"
                     /db_xref="CDD:440114"
     CDS             1..359
                     /gene="NOXRED1"
                     /gene_synonym="C14orf148"
                     /coded_by="XM_011536428.4:53..1132"
                     /db_xref="GeneID:122945"
                     /db_xref="HGNC:HGNC:20487"
ORIGIN      
        1 mdmlqdlesl qfeygvpeed riwlylqgrs rglmieacah atffckllyn lraslnknqs
       61 srhlsigsln satpeefkvg iiggghlgkq lagtllqlgp ipaeslrist rrpetlgelq
      121 klgikcfyhn adlvswadvi flcclpsqlp nicveiytsl ekasivysfv aaiplprlkl
      181 llnhtnilrp qyqydedsvs vwgankgvia alqdptilqa tcpyspaggi ilnikwlegv
      241 fyaalnicta rnmahsqvlq llselflsvh fedcgkdtas cpklqltdfv skaygknlsq
      301 erpfpwfdlt avqlketpfs qhlssspvlq dhlthlycas fgisltkeqp vistgfpsq
//
LOCUS       XP_011534731             269 aa            linear   PRI 05-AUG-2025
DEFINITION  NADP-dependent oxidoreductase domain-containing protein 1 isoform
            X2 [Homo sapiens].
ACCESSION   XP_011534731
VERSION     XP_011534731.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536429.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..269
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..269
                     /product="NADP-dependent oxidoreductase domain-containing
                     protein 1 isoform X2"
                     /calculated_mol_wt=29821
     Region          30..>99
                     /region_name="ProC"
                     /note="Pyrroline-5-carboxylate reductase [Amino acid
                     transport and metabolism]; COG0345"
                     /db_xref="CDD:440114"
     CDS             1..269
                     /gene="NOXRED1"
                     /gene_synonym="C14orf148"
                     /coded_by="XM_011536429.4:351..1160"
                     /db_xref="GeneID:122945"
                     /db_xref="HGNC:HGNC:20487"
ORIGIN      
        1 mlatpvlrnc fkgirlhlll lhfaipgelq klgikcfyhn adlvswadvi flcclpsqlp
       61 nicveiytsl ekasivysfv aaiplprlkl llnhtnilrp qyqydedsvs vwgankgvia
      121 alqdptilqa tcpyspaggi ilnikwlegv fyaalnicta rnmahsqvlq llselflsvh
      181 fedcgkdtas cpklqltdfv skaygknlsq erpfpwfdlt avqlketpfs qhlssspvlq
      241 dhlthlycas fgisltkeqp vistgfpsq
//
LOCUS       XP_016876458             234 aa            linear   PRI 05-AUG-2025
DEFINITION  NADP-dependent oxidoreductase domain-containing protein 1 isoform
            X3 [Homo sapiens].
ACCESSION   XP_016876458
VERSION     XP_016876458.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020969.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..234
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..234
                     /product="NADP-dependent oxidoreductase domain-containing
                     protein 1 isoform X3"
                     /calculated_mol_wt=25911
     Region          78..>177
                     /region_name="ProC"
                     /note="Pyrroline-5-carboxylate reductase [Amino acid
                     transport and metabolism]; COG0345"
                     /db_xref="CDD:440114"
     CDS             1..234
                     /gene="NOXRED1"
                     /gene_synonym="C14orf148"
                     /coded_by="XM_017020969.3:635..1339"
                     /db_xref="GeneID:122945"
                     /db_xref="HGNC:HGNC:20487"
ORIGIN      
        1 mdmlqdlesl qfeygvpeed riwlylqgrs rglmieacah atffckllyn lraslnknqs
       61 srhlsigsln satpeefkvg iiggghlgkq lagtllqlgp ipaeslrist rrpetlgelq
      121 klgikcfyhn adlvswadvi flcclpsqlp nicveiytsl ekasivysfv aaiplprpfp
      181 wfdltavqlk etpfsqhlss spvlqdhlth lycasfgisl tkeqpvistg fpsq
//
LOCUS       XP_047286898             206 aa            linear   PRI 05-AUG-2025
DEFINITION  jun dimerization protein 2 isoform X1 [Homo sapiens].
ACCESSION   XP_047286898
VERSION     XP_047286898.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430942.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 26% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..206
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..206
                     /product="jun dimerization protein 2 isoform X1"
                     /calculated_mol_wt=23568
     Region          125..178
                     /region_name="bZIP_ATF3"
                     /note="Basic leucine zipper (bZIP) domain of Activating
                     Transcription Factor-3 (ATF-3) and similar proteins: a
                     DNA-binding and dimerization domain; cd14722"
                     /db_xref="CDD:269870"
     Region          125..175
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:269870"
     Site            order(136,139..140,143..144,146..147,150..151,153..154,
                     157..158,160..161,164..165,167..168,171..172,174..175)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:269870"
     CDS             1..206
                     /gene="JDP2"
                     /gene_synonym="JUNDM2"
                     /coded_by="XM_047430942.1:566..1186"
                     /db_xref="GeneID:122953"
                     /db_xref="HGNC:HGNC:17546"
                     /db_xref="MIM:608657"
ORIGIN      
        1 mwpseyincp tekycpmdir sslfcqihls pweetgwpat ppammpgqip dpsvttgslp
       61 glgpltglps saltveelky adirnlgami aplhflevkl gkrpqpvkse ldeeeerrkr
      121 rreknkvaaa rcrnkkkert eflqreserl elmnaelktq ieelkqerqq lilmlnrhrp
      181 tcivrtdsvk tpesegnpll eqlekk
//
LOCUS       XP_047286899             174 aa            linear   PRI 05-AUG-2025
DEFINITION  jun dimerization protein 2 isoform X2 [Homo sapiens].
ACCESSION   XP_047286899
VERSION     XP_047286899.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430943.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..174
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..174
                     /product="jun dimerization protein 2 isoform X2"
                     /calculated_mol_wt=19652
     Region          93..146
                     /region_name="bZIP_ATF3"
                     /note="Basic leucine zipper (bZIP) domain of Activating
                     Transcription Factor-3 (ATF-3) and similar proteins: a
                     DNA-binding and dimerization domain; cd14722"
                     /db_xref="CDD:269870"
     Region          93..143
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:269870"
     Site            order(104,107..108,111..112,114..115,118..119,121..122,
                     125..126,128..129,132..133,135..136,139..140,142..143)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:269870"
     CDS             1..174
                     /gene="JDP2"
                     /gene_synonym="JUNDM2"
                     /coded_by="XM_047430943.1:3022..3546"
                     /db_xref="GeneID:122953"
                     /db_xref="HGNC:HGNC:17546"
                     /db_xref="MIM:608657"
ORIGIN      
        1 mvagwpatpp ammpgqipdp svttgslpgl gpltglpssa ltveelkyad irnlgamiap
       61 lhflevklgk rpqpvkseld eeeerrkrrr eknkvaaarc rnkkkertef lqreserlel
      121 mnaelktqie elkqerqqli lmlnrhrptc ivrtdsvktp esegnplleq lekk
//
LOCUS       XP_047286900             174 aa            linear   PRI 05-AUG-2025
DEFINITION  jun dimerization protein 2 isoform X2 [Homo sapiens].
ACCESSION   XP_047286900
VERSION     XP_047286900.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430944.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 30% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..174
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..174
                     /product="jun dimerization protein 2 isoform X2"
                     /calculated_mol_wt=19652
     Region          93..146
                     /region_name="bZIP_ATF3"
                     /note="Basic leucine zipper (bZIP) domain of Activating
                     Transcription Factor-3 (ATF-3) and similar proteins: a
                     DNA-binding and dimerization domain; cd14722"
                     /db_xref="CDD:269870"
     Region          93..143
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:269870"
     Site            order(104,107..108,111..112,114..115,118..119,121..122,
                     125..126,128..129,132..133,135..136,139..140,142..143)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:269870"
     CDS             1..174
                     /gene="JDP2"
                     /gene_synonym="JUNDM2"
                     /coded_by="XM_047430944.1:441..965"
                     /db_xref="GeneID:122953"
                     /db_xref="HGNC:HGNC:17546"
                     /db_xref="MIM:608657"
ORIGIN      
        1 mvagwpatpp ammpgqipdp svttgslpgl gpltglpssa ltveelkyad irnlgamiap
       61 lhflevklgk rpqpvkseld eeeerrkrrr eknkvaaarc rnkkkertef lqreserlel
      121 mnaelktqie elkqerqqli lmlnrhrptc ivrtdsvktp esegnplleq lekk
//
LOCUS       XP_005267389             163 aa            linear   PRI 05-AUG-2025
DEFINITION  jun dimerization protein 2 isoform X3 [Homo sapiens].
ACCESSION   XP_005267389
VERSION     XP_005267389.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267332.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..163
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..163
                     /product="jun dimerization protein 2 isoform X3"
                     /calculated_mol_wt=18573
     Region          82..135
                     /region_name="bZIP"
                     /note="Basic leucine zipper (bZIP) domain of bZIP
                     transcription factors: a DNA-binding and dimerization
                     domain; cl21462"
                     /db_xref="CDD:473870"
     Region          82..126
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:269834"
     Site            order(93,96..97,100..101,103..104,107..108,110..111,
                     114..115,117..118,121..122,124..125)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:269834"
     CDS             1..163
                     /gene="JDP2"
                     /gene_synonym="JUNDM2"
                     /coded_by="XM_005267332.5:2834..3325"
                     /db_xref="GeneID:122953"
                     /db_xref="HGNC:HGNC:17546"
                     /db_xref="MIM:608657"
ORIGIN      
        1 mmpgqipdps vttgslpglg pltglpssal tveelkyadi rnlgamiapl hflevklgkr
       61 pqpvkselde eeerrkrrre knkvaaarcr nkkkertefl qreserlelm naelktqiee
      121 lkqerqqlil mlnrhrptci vrtdsvktpe segnplleql ekk
//
LOCUS       XP_016876462             163 aa            linear   PRI 05-AUG-2025
DEFINITION  jun dimerization protein 2 isoform X3 [Homo sapiens].
ACCESSION   XP_016876462
VERSION     XP_016876462.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017020973.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..163
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..163
                     /product="jun dimerization protein 2 isoform X3"
                     /calculated_mol_wt=18573
     Region          82..135
                     /region_name="bZIP"
                     /note="Basic leucine zipper (bZIP) domain of bZIP
                     transcription factors: a DNA-binding and dimerization
                     domain; cl21462"
                     /db_xref="CDD:473870"
     Region          82..126
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:269834"
     Site            order(93,96..97,100..101,103..104,107..108,110..111,
                     114..115,117..118,121..122,124..125)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:269834"
     CDS             1..163
                     /gene="JDP2"
                     /gene_synonym="JUNDM2"
                     /coded_by="XM_017020973.2:83..574"
                     /db_xref="GeneID:122953"
                     /db_xref="HGNC:HGNC:17546"
                     /db_xref="MIM:608657"
ORIGIN      
        1 mmpgqipdps vttgslpglg pltglpssal tveelkyadi rnlgamiapl hflevklgkr
       61 pqpvkselde eeerrkrrre knkvaaarcr nkkkertefl qreserlelm naelktqiee
      121 lkqerqqlil mlnrhrptci vrtdsvktpe segnplleql ekk
//
LOCUS       XP_011534735             503 aa            linear   PRI 05-AUG-2025
DEFINITION  tetratricopeptide repeat protein 8 isoform X1 [Homo sapiens].
ACCESSION   XP_011534735
VERSION     XP_011534735.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536433.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..503
                     /product="tetratricopeptide repeat protein 8 isoform X1"
                     /calculated_mol_wt=57162
     Region          30..169
                     /region_name="TTC8_N"
                     /note="N-terminal domain of tetratricopeptide repeat
                     domain 8; cd21341"
                     /db_xref="CDD:411061"
     Site            order(246,249..250,252,275,278..279,282..283,285..286,309,
                     312..313,316..317,320)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          246..269
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          248..482
                     /region_name="LapB"
                     /note="Lipopolysaccharide biosynthesis regulator
                     YciM/LapB, contains six TPR domains and a C-terminal
                     metal-binding domain [Cell wall/membrane/envelope
                     biogenesis]; COG2956"
                     /db_xref="CDD:442196"
     Region          273..303
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          308..336
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          342..370
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(377,380..381,384..385,387,414,417..418,421..422,
                     424..425,448,451..452,455..456,459)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          377..404
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          409..442
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..503
                     /gene="TTC8"
                     /gene_synonym="BBS8; RP51"
                     /coded_by="XM_011536433.3:135..1646"
                     /db_xref="GeneID:123016"
                     /db_xref="HGNC:HGNC:20087"
                     /db_xref="MIM:608132"
ORIGIN      
        1 mssemeplll awsyfrrrkf qlcadlctqm lekspydqaa wilkaralte mvyideidvd
       61 qegiaemmld enaiaqvprp gtslklpgtn qtggpsqavr pitqagrpit gflrpstqsg
      121 rpgtmeqair tprtaytarp itsssgrfvr lgtasmltsp dgpfinlsrl nltkysqkpk
      181 lakalfeyif hhendvktih ledvvlhlgi ypfllrnknh ieknaldlaa lstehsqykd
      241 wwwkvqigkc yyrlgmyrea ekqfksalkq qemvdtflyl akvyvsldqp vtalnlfkqg
      301 ldkfpgevtl lcgiariyee mnnmssaaey ykevlkqdnt hveaiacigs nhfysdqpei
      361 alrfyrrllq mgiyngqlfn nlglccfyaq qydmtltsfe ralslaenee eaadvwynlg
      421 hvavgigdtn lahqcfrlal vnnnnhaeay nnlavlemrk ghveqigdlq rsyvaaqkse
      481 aafpdhvdtq hlikqlrqhf aml
//
LOCUS       XP_011534736             501 aa            linear   PRI 05-AUG-2025
DEFINITION  tetratricopeptide repeat protein 8 isoform X2 [Homo sapiens].
ACCESSION   XP_011534736
VERSION     XP_011534736.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536434.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..501
                     /product="tetratricopeptide repeat protein 8 isoform X2"
                     /calculated_mol_wt=56959
     Region          30..154
                     /region_name="TTC8_N"
                     /note="N-terminal domain of tetratricopeptide repeat
                     domain 8; cd21341"
                     /db_xref="CDD:411061"
     Site            order(216,219..220,222,245,248..249,252..253,255..256,279,
                     282..283,286..287,290)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          216..239
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          218..497
                     /region_name="LapB"
                     /note="Lipopolysaccharide biosynthesis regulator
                     YciM/LapB, contains six TPR domains and a C-terminal
                     metal-binding domain [Cell wall/membrane/envelope
                     biogenesis]; COG2956"
                     /db_xref="CDD:442196"
     Region          243..273
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          278..306
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          312..340
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(347,350..351,354..355,357,384,387..388,391..392,
                     394..395,418,421..422,425..426,429)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          347..374
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          379..412
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          417..443
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          451..476
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..501
                     /gene="TTC8"
                     /gene_synonym="BBS8; RP51"
                     /coded_by="XM_011536434.3:135..1640"
                     /db_xref="GeneID:123016"
                     /db_xref="HGNC:HGNC:20087"
                     /db_xref="MIM:608132"
ORIGIN      
        1 mssemeplll awsyfrrrkf qlcadlctqm lekspydqaa wilkaralte mvyideidvd
       61 qegiaemmld enaiaqvprp gtslklpgtn qtggpsqavr pitqagrpit gflrpstqsg
      121 rpgtmeqair tprtaytarp itsssgrfvr lgtalfeyif hhendvktih ledvvlhlgi
      181 ypfllrnknh ieknaldlaa lstehsqykd wwwkvqigkc yyrlgmyrea ekqfksalkq
      241 qemvdtflyl akvyvsldqp vtalnlfkqg ldkfpgevtl lcgiariyee mnnmssaaey
      301 ykevlkqdnt hveaiacigs nhfysdqpei alrfyrrllq mgiyngqlfn nlglccfyaq
      361 qydmtltsfe ralslaenee eaadvwynlg hvavgigdtn lahqcfrlal vnnnnhaeay
      421 nnlavlemrk ghveqarall qtasslaphm yephfnfati sdkigdlqrs yvaaqkseaa
      481 fpdhvdtqhl ikqlrqhfam l
//
LOCUS       XP_011534738             669 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium/potassium/calcium exchanger 4 isoform X1 [Homo sapiens].
ACCESSION   XP_011534738
VERSION     XP_011534738.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536436.3
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 23% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..669
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..669
                     /product="sodium/potassium/calcium exchanger 4 isoform X1"
                     /calculated_mol_wt=73628
     Region          <75..653
                     /region_name="2A1904"
                     /note="K+-dependent Na+/Ca+ exchanger; TIGR00927"
                     /db_xref="CDD:273344"
     CDS             1..669
                     /gene="SLC24A4"
                     /gene_synonym="AI2A5; NCKX4; SHEP6; SLC24A2"
                     /coded_by="XM_011536436.3:667..2676"
                     /db_xref="GeneID:123041"
                     /db_xref="HGNC:HGNC:10978"
                     /db_xref="MIM:609840"
ORIGIN      
        1 malrgtlrpl kvrrrremlp qqvgfvcavl alvccasglf gslgwsqgfi qspprragra
       61 rpeelmdalg cgagspelra apggaqdaaa ghktasaskr vlpdtwrnrk lmapvngtqt
      121 aknctdpaih efptdlfsnk erqhgavllh ilgalymfya laivcddffv pslekicerl
      181 hlsedvagat fmaagsstpe lfasvigvfi thgdvgvgti vgsavfnilc iigvcglfag
      241 qvvrltwwav crdsvyytis vivlivfiyd eqivwweglv liilyvfyil imkynvkmqa
      301 fftvkqksia ngnpvnsele agndfydgsy ddpsvpllgq vkekpqygkn pvvmvdeims
      361 ssppkftfpe aglrimitnk fgprtrlrma sriiinerqr linsangvss kplqngrhen
      421 iengnvpven pedpqqnqeq qpppqppppe pepveadfls pfsvpeargd kvkwvftwpl
      481 ifllcvtipn cskprwekff mvtfitatlw iavfsyimvw lvtiigytlg ipdvimgitf
      541 laagtsvpdc maslivarqg lgdmavsnti gsnvfdilvg lgvpwglqtm vvnygstvki
      601 nsrglvysvv lllgsvaltv lgihlnkwrl drklgvyvlv lyaiflcfsi miefnvftfv
      661 nlpmcredd
//
LOCUS       XP_011534739             650 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium/potassium/calcium exchanger 4 isoform X2 [Homo sapiens].
ACCESSION   XP_011534739
VERSION     XP_011534739.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536437.3
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 24% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..650
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..650
                     /product="sodium/potassium/calcium exchanger 4 isoform X2"
                     /calculated_mol_wt=71587
     Region          <75..634
                     /region_name="2A1904"
                     /note="K+-dependent Na+/Ca+ exchanger; TIGR00927"
                     /db_xref="CDD:273344"
     CDS             1..650
                     /gene="SLC24A4"
                     /gene_synonym="AI2A5; NCKX4; SHEP6; SLC24A2"
                     /coded_by="XM_011536437.3:667..2619"
                     /db_xref="GeneID:123041"
                     /db_xref="HGNC:HGNC:10978"
                     /db_xref="MIM:609840"
ORIGIN      
        1 malrgtlrpl kvrrrremlp qqvgfvcavl alvccasglf gslgwsqgfi qspprragra
       61 rpeelmdalg cgagspelra apggaqdaaa ghktasaskr vlpdtwrnrk lmapvngtqt
      121 aknctdpaih efptdlfsnk erqhgavllh ilgalymfya laivcddffv pslekicerl
      181 hlsedvagat fmaagsstpe lfasvigvfi thgdvgvgti vgsavfnilc iigvcglfag
      241 qvvrltwwav crdsvyytis vivlivfiyd eqivwweglv liilyvfyil imkynvkmqa
      301 fftvkqksia ngnpvnsele avkekpqygk npvvmvdeim sssppkftfp eaglrimitn
      361 kfgprtrlrm asriiinerq rlinsangvs skplqngrhe niengnvpve npedpqqnqe
      421 qqpppqpppp epepveadfl spfsvpearg dkvkwvftwp lifllcvtip ncskprwekf
      481 fmvtfitatl wiavfsyimv wlvtiigytl gipdvimgit flaagtsvpd cmaslivarq
      541 glgdmavsnt igsnvfdilv glgvpwglqt mvvnygstvk insrglvysv vlllgsvalt
      601 vlgihlnkwr ldrklgvyvl vlyaiflcfs imiefnvftf vnlpmcredd
//
LOCUS       XP_011534742             372 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium/potassium/calcium exchanger 4 isoform X4 [Homo sapiens].
ACCESSION   XP_011534742
VERSION     XP_011534742.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536440.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..372
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..372
                     /product="sodium/potassium/calcium exchanger 4 isoform X4"
                     /calculated_mol_wt=41247
     Region          <158..356
                     /region_name="2A1904"
                     /note="K+-dependent Na+/Ca+ exchanger; TIGR00927"
                     /db_xref="CDD:273344"
     CDS             1..372
                     /gene="SLC24A4"
                     /gene_synonym="AI2A5; NCKX4; SHEP6; SLC24A2"
                     /coded_by="XM_011536440.2:717..1835"
                     /db_xref="GeneID:123041"
                     /db_xref="HGNC:HGNC:10978"
                     /db_xref="MIM:609840"
ORIGIN      
        1 mqafftvkqk siangnpvns eleagndfyd gsyddpsvpl lgqvkekpqy gknpvvmvde
       61 imsssppkft fpeaglrimi tnkfgprtrl rmasriiine rqrlinsang vsskplqngr
      121 heniengnvp venpedpqqn qeqqpppqpp ppepepvead flspfsvpea rgdkvkwvft
      181 wplifllcvt ipncskprwe kffmvtfita tlwiavfsyi mvwlvtiigy tlgipdvimg
      241 itflaagtsv pdcmasliva rqglgdmavs ntigsnvfdi lvglgvpwgl qtmvvnygst
      301 vkinsrglvy svvlllgsva ltvlgihlnk wrldrklgvy vlvlyaiflc fsimiefnvf
      361 tfvnlpmcre dd
//
LOCUS       XP_005267399             352 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium/potassium/calcium exchanger 4 isoform X5 [Homo sapiens].
ACCESSION   XP_005267399
VERSION     XP_005267399.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267342.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..352
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..352
                     /product="sodium/potassium/calcium exchanger 4 isoform X5"
                     /calculated_mol_wt=39552
     Region          <1..>104
                     /region_name="2A1904"
                     /note="K+-dependent Na+/Ca+ exchanger; TIGR00927"
                     /db_xref="CDD:273344"
     CDS             1..352
                     /gene="SLC24A4"
                     /gene_synonym="AI2A5; NCKX4; SHEP6; SLC24A2"
                     /coded_by="XM_005267342.2:137..1195"
                     /db_xref="GeneID:123041"
                     /db_xref="HGNC:HGNC:10978"
                     /db_xref="MIM:609840"
ORIGIN      
        1 mfyalaivcd dffvpsleki cerlhlsedv agatfmaags stpelfasvi gvfithgdvg
       61 vgtisvivli vfiydeqivw weglvliily vfyilimkyn vkmqafftvk qksiangnpv
      121 nseleagndf ydgsyddpsv pllgqvkekp qygknpvvmv deimsssppk ftfpeaglri
      181 mitnkfgprt rlrmasriii nerqrlinsa ngvsskplqn grheniengn vpvenpedpq
      241 qnqeqqpppq ppppepepve adflspfsvp eargdkvkwv ftwplifllc vtipncskpr
      301 wekffmvtfi tatlwiavfs yimvwleqre gkqfqhgcss vdcethsqpl tp
//
LOCUS       XP_047286902             350 aa            linear   PRI 05-AUG-2025
DEFINITION  mitochondrial basic amino acids transporter isoform X1 [Homo
            sapiens].
ACCESSION   XP_047286902
VERSION     XP_047286902.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430946.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..350
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..350
                     /product="mitochondrial basic amino acids transporter
                     isoform X1"
                     /calculated_mol_wt=37218
     Region          59..126
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     Region          135..227
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     Region          232..315
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     CDS             1..350
                     /gene="SLC25A29"
                     /gene_synonym="C14orf69; CACL; ORNT3"
                     /coded_by="XM_047430946.1:959..2011"
                     /db_xref="GeneID:123096"
                     /db_xref="HGNC:HGNC:20116"
                     /db_xref="MIM:615064"
ORIGIN      
        1 mppapatqts qprraaacrw dtsaewdrcw lglgmshayp psgredsrgs wdlpaaptgv
       61 agvlvghpfd tvkvrlqvqs vekpqyrgtl hcfksiikqe svlglykglg splmgltfin
      121 alvfgvqgnt lralghdspl nqflagaaag aiqcviccpm elaktrlqlq dagpartykg
      181 sldclaqiyg heglrgvnrg mvstllretp sfgvyfltyd altralgcep gdrllvpkll
      241 laggtsgivs wlstypvdvv ksrlqadglr gapryrgild cvhqsyraeg wrvftrglas
      301 tllrafpvna atfatvtvvl tyargeeagp egeavpaapa gpalaqpssl
//
LOCUS       XP_047286903             348 aa            linear   PRI 05-AUG-2025
DEFINITION  mitochondrial basic amino acids transporter isoform X2 [Homo
            sapiens].
ACCESSION   XP_047286903
VERSION     XP_047286903.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430947.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..348
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..348
                     /product="mitochondrial basic amino acids transporter
                     isoform X2"
                     /calculated_mol_wt=37084
     Region          57..124
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     Region          133..225
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     Region          230..313
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     CDS             1..348
                     /gene="SLC25A29"
                     /gene_synonym="C14orf69; CACL; ORNT3"
                     /coded_by="XM_047430947.1:1591..2637"
                     /db_xref="GeneID:123096"
                     /db_xref="HGNC:HGNC:20116"
                     /db_xref="MIM:615064"
ORIGIN      
        1 mveatqtsqp rraaacrwdt saewdrcwlg lgmshaypps gredsrgswd lpaaptgvag
       61 vlvghpfdtv kvrlqvqsve kpqyrgtlhc fksiikqesv lglykglgsp lmgltfinal
      121 vfgvqgntlr alghdsplnq flagaaagai qcviccpmel aktrlqlqda gpartykgsl
      181 dclaqiyghe glrgvnrgmv stllretpsf gvyfltydal tralgcepgd rllvpkllla
      241 ggtsgivswl stypvdvvks rlqadglrga pryrgildcv hqsyraegwr vftrglastl
      301 lrafpvnaat fatvtvvlty argeeagpeg eavpaapagp alaqpssl
//
LOCUS       XP_047286904             348 aa            linear   PRI 05-AUG-2025
DEFINITION  mitochondrial basic amino acids transporter isoform X2 [Homo
            sapiens].
ACCESSION   XP_047286904
VERSION     XP_047286904.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430948.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..348
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..348
                     /product="mitochondrial basic amino acids transporter
                     isoform X2"
                     /calculated_mol_wt=37084
     Region          57..124
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     Region          133..225
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     Region          230..313
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     CDS             1..348
                     /gene="SLC25A29"
                     /gene_synonym="C14orf69; CACL; ORNT3"
                     /coded_by="XM_047430948.1:1020..2066"
                     /db_xref="GeneID:123096"
                     /db_xref="HGNC:HGNC:20116"
                     /db_xref="MIM:615064"
ORIGIN      
        1 mveatqtsqp rraaacrwdt saewdrcwlg lgmshaypps gredsrgswd lpaaptgvag
       61 vlvghpfdtv kvrlqvqsve kpqyrgtlhc fksiikqesv lglykglgsp lmgltfinal
      121 vfgvqgntlr alghdsplnq flagaaagai qcviccpmel aktrlqlqda gpartykgsl
      181 dclaqiyghe glrgvnrgmv stllretpsf gvyfltydal tralgcepgd rllvpkllla
      241 ggtsgivswl stypvdvvks rlqadglrga pryrgildcv hqsyraegwr vftrglastl
      301 lrafpvnaat fatvtvvlty argeeagpeg eavpaapagp alaqpssl
//
LOCUS       XP_006720102             342 aa            linear   PRI 05-AUG-2025
DEFINITION  mitochondrial basic amino acids transporter isoform X3 [Homo
            sapiens].
ACCESSION   XP_006720102
VERSION     XP_006720102.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720039.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..342
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..342
                     /product="mitochondrial basic amino acids transporter
                     isoform X3"
                     /calculated_mol_wt=36262
     Region          51..118
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     Region          127..219
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     Region          224..307
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     CDS             1..342
                     /gene="SLC25A29"
                     /gene_synonym="C14orf69; CACL; ORNT3"
                     /coded_by="XM_006720039.5:213..1241"
                     /db_xref="GeneID:123096"
                     /db_xref="HGNC:HGNC:20116"
                     /db_xref="MIM:615064"
ORIGIN      
        1 maldflagca gaiqrgwgyg adpllgwpwr alnhsgaesr lgtpplptrf cvagvlvghp
       61 fdtvkvrlqv qsvekpqyrg tlhcfksiik qesvlglykg lgsplmgltf inalvfgvqg
      121 ntlralghds plnqflagaa agaiqcvicc pmelaktrlq lqdagparty kgsldclaqi
      181 ygheglrgvn rgmvstllre tpsfgvyflt ydaltralgc epgdrllvpk lllaggtsgi
      241 vswlstypvd vvksrlqadg lrgapryrgi ldcvhqsyra egwrvftrgl astllrafpv
      301 naatfatvtv vltyargeea gpegeavpaa pagpalaqps sl
//
LOCUS       XP_047286905             297 aa            linear   PRI 05-AUG-2025
DEFINITION  mitochondrial basic amino acids transporter isoform X4 [Homo
            sapiens].
ACCESSION   XP_047286905
VERSION     XP_047286905.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430949.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..297
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..297
                     /product="mitochondrial basic amino acids transporter
                     isoform X4"
                     /calculated_mol_wt=31375
     Region          6..73
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     Region          82..174
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     Region          179..262
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     CDS             1..297
                     /gene="SLC25A29"
                     /gene_synonym="C14orf69; CACL; ORNT3"
                     /coded_by="XM_047430949.1:958..1851"
                     /db_xref="GeneID:123096"
                     /db_xref="HGNC:HGNC:20116"
                     /db_xref="MIM:615064"
ORIGIN      
        1 mppapgvagv lvghpfdtvk vrlqvqsvek pqyrgtlhcf ksiikqesvl glykglgspl
       61 mgltfinalv fgvqgntlra lghdsplnqf lagaaagaiq cviccpmela ktrlqlqdag
      121 partykgsld claqiygheg lrgvnrgmvs tllretpsfg vyfltydalt ralgcepgdr
      181 llvpklllag gtsgivswls typvdvvksr lqadglrgap ryrgildcvh qsyraegwrv
      241 ftrglastll rafpvnaatf atvtvvltya rgeeagpege avpaapagpa laqpssl
//
LOCUS       XP_047286906             237 aa            linear   PRI 05-AUG-2025
DEFINITION  mitochondrial basic amino acids transporter isoform X5 [Homo
            sapiens].
ACCESSION   XP_047286906
VERSION     XP_047286906.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430950.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 15% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..237
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..237
                     /product="mitochondrial basic amino acids transporter
                     isoform X5"
                     /calculated_mol_wt=24920
     Region          22..114
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     Region          119..202
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     CDS             1..237
                     /gene="SLC25A29"
                     /gene_synonym="C14orf69; CACL; ORNT3"
                     /coded_by="XM_047430950.1:2889..3602"
                     /db_xref="GeneID:123096"
                     /db_xref="HGNC:HGNC:20116"
                     /db_xref="MIM:615064"
ORIGIN      
        1 mgltfinalv fgvqgntlra lghdsplnqf lagaaagaiq cviccpmela ktrlqlqdag
       61 partykgsld claqiygheg lrgvnrgmvs tllretpsfg vyfltydalt ralgcepgdr
      121 llvpklllag gtsgivswls typvdvvksr lqadglrgap ryrgildcvh qsyraegwrv
      181 ftrglastll rafpvnaatf atvtvvltya rgeeagpege avpaapagpa laqpssl
//
LOCUS       XP_047286907             237 aa            linear   PRI 05-AUG-2025
DEFINITION  mitochondrial basic amino acids transporter isoform X5 [Homo
            sapiens].
ACCESSION   XP_047286907
VERSION     XP_047286907.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430951.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..237
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..237
                     /product="mitochondrial basic amino acids transporter
                     isoform X5"
                     /calculated_mol_wt=24920
     Region          22..114
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     Region          119..202
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     CDS             1..237
                     /gene="SLC25A29"
                     /gene_synonym="C14orf69; CACL; ORNT3"
                     /coded_by="XM_047430951.1:3701..4414"
                     /db_xref="GeneID:123096"
                     /db_xref="HGNC:HGNC:20116"
                     /db_xref="MIM:615064"
ORIGIN      
        1 mgltfinalv fgvqgntlra lghdsplnqf lagaaagaiq cviccpmela ktrlqlqdag
       61 partykgsld claqiygheg lrgvnrgmvs tllretpsfg vyfltydalt ralgcepgdr
      121 llvpklllag gtsgivswls typvdvvksr lqadglrgap ryrgildcvh qsyraegwrv
      181 ftrglastll rafpvnaatf atvtvvltya rgeeagpege avpaapagpa laqpssl
//
LOCUS       XP_047286908             237 aa            linear   PRI 05-AUG-2025
DEFINITION  mitochondrial basic amino acids transporter isoform X5 [Homo
            sapiens].
ACCESSION   XP_047286908
VERSION     XP_047286908.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430952.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 27% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..237
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..237
                     /product="mitochondrial basic amino acids transporter
                     isoform X5"
                     /calculated_mol_wt=24920
     Region          22..114
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     Region          119..202
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     CDS             1..237
                     /gene="SLC25A29"
                     /gene_synonym="C14orf69; CACL; ORNT3"
                     /coded_by="XM_047430952.1:2976..3689"
                     /db_xref="GeneID:123096"
                     /db_xref="HGNC:HGNC:20116"
                     /db_xref="MIM:615064"
ORIGIN      
        1 mgltfinalv fgvqgntlra lghdsplnqf lagaaagaiq cviccpmela ktrlqlqdag
       61 partykgsld claqiygheg lrgvnrgmvs tllretpsfg vyfltydalt ralgcepgdr
      121 llvpklllag gtsgivswls typvdvvksr lqadglrgap ryrgildcvh qsyraegwrv
      181 ftrglastll rafpvnaatf atvtvvltya rgeeagpege avpaapagpa laqpssl
//
LOCUS       XP_047286909             237 aa            linear   PRI 05-AUG-2025
DEFINITION  mitochondrial basic amino acids transporter isoform X5 [Homo
            sapiens].
ACCESSION   XP_047286909
VERSION     XP_047286909.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430953.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..237
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..237
                     /product="mitochondrial basic amino acids transporter
                     isoform X5"
                     /calculated_mol_wt=24920
     Region          22..114
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     Region          119..202
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     CDS             1..237
                     /gene="SLC25A29"
                     /gene_synonym="C14orf69; CACL; ORNT3"
                     /coded_by="XM_047430953.1:1304..2017"
                     /db_xref="GeneID:123096"
                     /db_xref="HGNC:HGNC:20116"
                     /db_xref="MIM:615064"
ORIGIN      
        1 mgltfinalv fgvqgntlra lghdsplnqf lagaaagaiq cviccpmela ktrlqlqdag
       61 partykgsld claqiygheg lrgvnrgmvs tllretpsfg vyfltydalt ralgcepgdr
      121 llvpklllag gtsgivswls typvdvvksr lqadglrgap ryrgildcvh qsyraegwrv
      181 ftrglastll rafpvnaatf atvtvvltya rgeeagpege avpaapagpa laqpssl
//
LOCUS       XP_047286910             237 aa            linear   PRI 05-AUG-2025
DEFINITION  mitochondrial basic amino acids transporter isoform X5 [Homo
            sapiens].
ACCESSION   XP_047286910
VERSION     XP_047286910.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430954.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..237
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..237
                     /product="mitochondrial basic amino acids transporter
                     isoform X5"
                     /calculated_mol_wt=24920
     Region          22..114
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     Region          119..202
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     CDS             1..237
                     /gene="SLC25A29"
                     /gene_synonym="C14orf69; CACL; ORNT3"
                     /coded_by="XM_047430954.1:1294..2007"
                     /db_xref="GeneID:123096"
                     /db_xref="HGNC:HGNC:20116"
                     /db_xref="MIM:615064"
ORIGIN      
        1 mgltfinalv fgvqgntlra lghdsplnqf lagaaagaiq cviccpmela ktrlqlqdag
       61 partykgsld claqiygheg lrgvnrgmvs tllretpsfg vyfltydalt ralgcepgdr
      121 llvpklllag gtsgivswls typvdvvksr lqadglrgap ryrgildcvh qsyraegwrv
      181 ftrglastll rafpvnaatf atvtvvltya rgeeagpege avpaapagpa laqpssl
//
LOCUS       XP_047286912             237 aa            linear   PRI 05-AUG-2025
DEFINITION  mitochondrial basic amino acids transporter isoform X5 [Homo
            sapiens].
ACCESSION   XP_047286912
VERSION     XP_047286912.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430956.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 16% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..237
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..237
                     /product="mitochondrial basic amino acids transporter
                     isoform X5"
                     /calculated_mol_wt=24920
     Region          22..114
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     Region          119..202
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     CDS             1..237
                     /gene="SLC25A29"
                     /gene_synonym="C14orf69; CACL; ORNT3"
                     /coded_by="XM_047430956.1:692..1405"
                     /db_xref="GeneID:123096"
                     /db_xref="HGNC:HGNC:20116"
                     /db_xref="MIM:615064"
ORIGIN      
        1 mgltfinalv fgvqgntlra lghdsplnqf lagaaagaiq cviccpmela ktrlqlqdag
       61 partykgsld claqiygheg lrgvnrgmvs tllretpsfg vyfltydalt ralgcepgdr
      121 llvpklllag gtsgivswls typvdvvksr lqadglrgap ryrgildcvh qsyraegwrv
      181 ftrglastll rafpvnaatf atvtvvltya rgeeagpege avpaapagpa laqpssl
//
LOCUS       XP_047286913             237 aa            linear   PRI 05-AUG-2025
DEFINITION  mitochondrial basic amino acids transporter isoform X5 [Homo
            sapiens].
ACCESSION   XP_047286913
VERSION     XP_047286913.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430957.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..237
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..237
                     /product="mitochondrial basic amino acids transporter
                     isoform X5"
                     /calculated_mol_wt=24920
     Region          22..114
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     Region          119..202
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     CDS             1..237
                     /gene="SLC25A29"
                     /gene_synonym="C14orf69; CACL; ORNT3"
                     /coded_by="XM_047430957.1:1008..1721"
                     /db_xref="GeneID:123096"
                     /db_xref="HGNC:HGNC:20116"
                     /db_xref="MIM:615064"
ORIGIN      
        1 mgltfinalv fgvqgntlra lghdsplnqf lagaaagaiq cviccpmela ktrlqlqdag
       61 partykgsld claqiygheg lrgvnrgmvs tllretpsfg vyfltydalt ralgcepgdr
      121 llvpklllag gtsgivswls typvdvvksr lqadglrgap ryrgildcvh qsyraegwrv
      181 ftrglastll rafpvnaatf atvtvvltya rgeeagpege avpaapagpa laqpssl
//
LOCUS       XP_047286914             237 aa            linear   PRI 05-AUG-2025
DEFINITION  mitochondrial basic amino acids transporter isoform X5 [Homo
            sapiens].
ACCESSION   XP_047286914
VERSION     XP_047286914.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430958.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..237
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..237
                     /product="mitochondrial basic amino acids transporter
                     isoform X5"
                     /calculated_mol_wt=24920
     Region          22..114
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     Region          119..202
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     CDS             1..237
                     /gene="SLC25A29"
                     /gene_synonym="C14orf69; CACL; ORNT3"
                     /coded_by="XM_047430958.1:998..1711"
                     /db_xref="GeneID:123096"
                     /db_xref="HGNC:HGNC:20116"
                     /db_xref="MIM:615064"
ORIGIN      
        1 mgltfinalv fgvqgntlra lghdsplnqf lagaaagaiq cviccpmela ktrlqlqdag
       61 partykgsld claqiygheg lrgvnrgmvs tllretpsfg vyfltydalt ralgcepgdr
      121 llvpklllag gtsgivswls typvdvvksr lqadglrgap ryrgildcvh qsyraegwrv
      181 ftrglastll rafpvnaatf atvtvvltya rgeeagpege avpaapagpa laqpssl
//
LOCUS       XP_047286915             237 aa            linear   PRI 05-AUG-2025
DEFINITION  mitochondrial basic amino acids transporter isoform X5 [Homo
            sapiens].
ACCESSION   XP_047286915
VERSION     XP_047286915.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430959.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..237
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..237
                     /product="mitochondrial basic amino acids transporter
                     isoform X5"
                     /calculated_mol_wt=24920
     Region          22..114
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     Region          119..202
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     CDS             1..237
                     /gene="SLC25A29"
                     /gene_synonym="C14orf69; CACL; ORNT3"
                     /coded_by="XM_047430959.1:1506..2219"
                     /db_xref="GeneID:123096"
                     /db_xref="HGNC:HGNC:20116"
                     /db_xref="MIM:615064"
ORIGIN      
        1 mgltfinalv fgvqgntlra lghdsplnqf lagaaagaiq cviccpmela ktrlqlqdag
       61 partykgsld claqiygheg lrgvnrgmvs tllretpsfg vyfltydalt ralgcepgdr
      121 llvpklllag gtsgivswls typvdvvksr lqadglrgap ryrgildcvh qsyraegwrv
      181 ftrglastll rafpvnaatf atvtvvltya rgeeagpege avpaapagpa laqpssl
//
LOCUS       XP_047286916             237 aa            linear   PRI 05-AUG-2025
DEFINITION  mitochondrial basic amino acids transporter isoform X5 [Homo
            sapiens].
ACCESSION   XP_047286916
VERSION     XP_047286916.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430960.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..237
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..237
                     /product="mitochondrial basic amino acids transporter
                     isoform X5"
                     /calculated_mol_wt=24920
     Region          22..114
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     Region          119..202
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     CDS             1..237
                     /gene="SLC25A29"
                     /gene_synonym="C14orf69; CACL; ORNT3"
                     /coded_by="XM_047430960.1:936..1649"
                     /db_xref="GeneID:123096"
                     /db_xref="HGNC:HGNC:20116"
                     /db_xref="MIM:615064"
ORIGIN      
        1 mgltfinalv fgvqgntlra lghdsplnqf lagaaagaiq cviccpmela ktrlqlqdag
       61 partykgsld claqiygheg lrgvnrgmvs tllretpsfg vyfltydalt ralgcepgdr
      121 llvpklllag gtsgivswls typvdvvksr lqadglrgap ryrgildcvh qsyraegwrv
      181 ftrglastll rafpvnaatf atvtvvltya rgeeagpege avpaapagpa laqpssl
//
LOCUS       XP_047286917             237 aa            linear   PRI 05-AUG-2025
DEFINITION  mitochondrial basic amino acids transporter isoform X5 [Homo
            sapiens].
ACCESSION   XP_047286917
VERSION     XP_047286917.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430961.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..237
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..237
                     /product="mitochondrial basic amino acids transporter
                     isoform X5"
                     /calculated_mol_wt=24920
     Region          22..114
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     Region          119..202
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     CDS             1..237
                     /gene="SLC25A29"
                     /gene_synonym="C14orf69; CACL; ORNT3"
                     /coded_by="XM_047430961.1:926..1639"
                     /db_xref="GeneID:123096"
                     /db_xref="HGNC:HGNC:20116"
                     /db_xref="MIM:615064"
ORIGIN      
        1 mgltfinalv fgvqgntlra lghdsplnqf lagaaagaiq cviccpmela ktrlqlqdag
       61 partykgsld claqiygheg lrgvnrgmvs tllretpsfg vyfltydalt ralgcepgdr
      121 llvpklllag gtsgivswls typvdvvksr lqadglrgap ryrgildcvh qsyraegwrv
      181 ftrglastll rafpvnaatf atvtvvltya rgeeagpege avpaapagpa laqpssl
//
LOCUS       XP_047286918             237 aa            linear   PRI 05-AUG-2025
DEFINITION  mitochondrial basic amino acids transporter isoform X5 [Homo
            sapiens].
ACCESSION   XP_047286918
VERSION     XP_047286918.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430962.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 17% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..237
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..237
                     /product="mitochondrial basic amino acids transporter
                     isoform X5"
                     /calculated_mol_wt=24920
     Region          22..114
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     Region          119..202
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     CDS             1..237
                     /gene="SLC25A29"
                     /gene_synonym="C14orf69; CACL; ORNT3"
                     /coded_by="XM_047430962.1:396..1109"
                     /db_xref="GeneID:123096"
                     /db_xref="HGNC:HGNC:20116"
                     /db_xref="MIM:615064"
ORIGIN      
        1 mgltfinalv fgvqgntlra lghdsplnqf lagaaagaiq cviccpmela ktrlqlqdag
       61 partykgsld claqiygheg lrgvnrgmvs tllretpsfg vyfltydalt ralgcepgdr
      121 llvpklllag gtsgivswls typvdvvksr lqadglrgap ryrgildcvh qsyraegwrv
      181 ftrglastll rafpvnaatf atvtvvltya rgeeagpege avpaapagpa laqpssl
//
LOCUS       XP_006720106             287 aa            linear   PRI 05-AUG-2025
DEFINITION  sphingolipid delta(4)-desaturase/C4-monooxygenase DES2 isoform X1
            [Homo sapiens].
ACCESSION   XP_006720106
VERSION     XP_006720106.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720043.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..287
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..287
                     /product="sphingolipid
                     delta(4)-desaturase/C4-monooxygenase DES2 isoform X1"
                     /calculated_mol_wt=32876
     Region          1..278
                     /region_name="Delta4-sphingolipid-FADS-like"
                     /note="The Delta4-sphingolipid Fatty Acid Desaturase
                     (Delta4-sphingolipid-FADS)-like CD includes the
                     integral-membrane enzymes, dihydroceramide Delta-4
                     desaturase, involved in the synthesis of sphingosine; and
                     the human membrane fatty acid (lipid) desaturase...;
                     cd03508"
                     /db_xref="CDD:239585"
     Site            order(53,57,92,95..96,223,226..227)
                     /site_type="other"
                     /note="putative di-iron ligands [ion binding]"
                     /db_xref="CDD:239585"
     CDS             1..287
                     /gene="DEGS2"
                     /gene_synonym="C14orf66; DES2; FADS8"
                     /coded_by="XM_006720043.4:212..1075"
                     /db_xref="GeneID:123099"
                     /db_xref="HGNC:HGNC:20113"
                     /db_xref="MIM:610862"
ORIGIN      
        1 mrpdprlkwa vlvlvlvqml acwlvrglaw rwllfwayaf ggcvnhsltl aihdishnaa
       61 fgtgraarnr wlavfanlpv gvpyaasfkk yhvdhhrylg gdgldvdvpt rlegwffctp
      121 arkllwlvlq pffyslrplc vhpkavtrme vlntlvqlaa dlaifalwgl kpvvyllass
      181 flglglhpis ghfvaehymf lkghetysyy gplnwitfnv gyhvehhdfp sipgynlplv
      241 rkiapeyydh lpqhhswvkv lwdfvfedsl gpyarvkrvy rlakdgl
//
LOCUS       XP_011534752             797 aa            linear   PRI 05-AUG-2025
DEFINITION  kelch-like protein 33 isoform X1 [Homo sapiens].
ACCESSION   XP_011534752
VERSION     XP_011534752.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536450.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..797
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..797
                     /product="kelch-like protein 33 isoform X1"
                     /calculated_mol_wt=86450
     Region          95..193
                     /region_name="BTB1_POZ_KLHL33"
                     /note="first BTB (Broad-Complex, Tramtrack and Bric a
                     brac)/POZ (poxvirus and zinc finger) domain found in
                     Kelch-like protein 33 (KLHL33); cd18262"
                     /db_xref="CDD:349571"
     Region          224..341
                     /region_name="BTB_POZ"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain superfamily; cl38908"
                     /db_xref="CDD:453885"
     Region          334..408
                     /region_name="BACK_KLHL33"
                     /note="BACK (BTB and C-terminal Kelch) domain found in
                     Kelch-like protein 33 (KLHL33); cd18472"
                     /db_xref="CDD:350547"
     Region          512..774
                     /region_name="NanM"
                     /note="N-acetylneuraminic acid mutarotase [Cell
                     wall/membrane/envelope biogenesis]; COG3055"
                     /db_xref="CDD:442289"
     Region          525..574
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          576..619
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          623..669
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          672..717
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          719..765
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     CDS             1..797
                     /gene="KLHL33"
                     /coded_by="XM_011536450.3:235..2628"
                     /db_xref="GeneID:123103"
                     /db_xref="HGNC:HGNC:31952"
ORIGIN      
        1 msvsdtphyp pelesvshpv qrdclgllvh aqrtpswpps pdedprlpsf pleepgsrpl
       61 vprnlpfpal sleeeeeeee dedaaepewl rseehpsqff aeaqrlreqr llldeevsva
      121 grvygvhrvi laaisslfrd rllggggprp pfslevspgg weavltfaye gvlgpasqgd
      181 vlaaaealga prvkaaaqqt ceragnared vkkpsqaeel renlrgiell yregvgcdlk
      241 leaggcqlsv hraalacgse ffgamllsgm resqgtevsl rtistqdlrl lvsfaysgvv
      301 rarwpgllra aqaalqyqss scldlcqkgl arglsparcl alfpmaeapg lerlwskarh
      361 yllthlpava lcpafpslpa aclaelldsd elhvqeefea fvaarcwlaa npetqeseak
      421 allrcvrfgr mstrelrrvr aagllppltp dllhqlmvea dvpgqerrre pdralvvigg
      481 dglrpdmalr qpsravwwar afrcgvglvr tvewgqlpal papgrfrhga aslagselyv
      541 cggqdfyshs ntlastlrwe psqedweema plsqarslfs lvaldgklya lggrhndval
      601 dsvetynpel nvwrpapalp apcfahaaai legqlyvsgg cggtgqylas lmhydpklek
      661 pgtflspmgv praghvmaal ggrlyvaggl getedllsfe ayelrtdswt hlaplpsphv
      721 gaasavlqge llvlggyshr tyalshliha ycpglgrwlc lgtlprprae mpaciltlpa
      781 vqhialvptp hqtkpag
//
LOCUS       XP_047286921             316 aa            linear   PRI 05-AUG-2025
DEFINITION  retinol dehydrogenase 12 isoform X1 [Homo sapiens].
ACCESSION   XP_047286921
VERSION     XP_047286921.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430965.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 1% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..316
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..316
                     /product="retinol dehydrogenase 12 isoform X1"
                     /calculated_mol_wt=34963
     Region          39..307
                     /region_name="retinol-DH_like_SDR_c"
                     /note="retinol dehydrogenases (retinol-DHs), classical (c)
                     SDRs; cd09807"
                     /db_xref="CDD:212495"
     Site            order(46,48..51,70..72,97..99,125..127,146,179..181,200,
                     204,230..233,235..236)
                     /site_type="other"
                     /note="putative NAD(P) binding site [chemical binding]"
                     /db_xref="CDD:212495"
     Site            order(147,181,200,204)
                     /site_type="active"
                     /db_xref="CDD:212495"
     CDS             1..316
                     /gene="RDH12"
                     /gene_synonym="LCA13; RP53; SDR7C2"
                     /coded_by="XM_047430965.1:359..1309"
                     /db_xref="GeneID:145226"
                     /db_xref="HGNC:HGNC:19977"
                     /db_xref="MIM:608830"
ORIGIN      
        1 mlvtlgllts ffsflymvap sirkffaggv crtnvqlpgk vvvitgantg igketarela
       61 srgarvyiac rdvlkgesaa seirvdtkns qvlvrkldls dtksirafae gflaeekqlh
      121 ilinnagvmm cpysktadgf ethlgvnhlg hflltyllle rlkvsaparv vnvssvahhi
      181 gkipfhdlqs ekrysrgfay chsklanvlf trelakrlqg tgvttyavhp gvvrselvrh
      241 ssllcllwrl fspfvktare gaqtslhcal aegleplsgk yfsdckrtwv sprarnnkta
      301 erlwnvscel lgirwe
//
LOCUS       XP_011534758             153 aa            linear   PRI 05-AUG-2025
DEFINITION  proline-rich membrane anchor 1 isoform X1 [Homo sapiens].
ACCESSION   XP_011534758
VERSION     XP_011534758.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536456.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..153
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..153
                     /product="proline-rich membrane anchor 1 isoform X1"
                     /calculated_mol_wt=16558
     Region          37..153
                     /region_name="PRIMA1"
                     /note="Proline-rich membrane anchor 1; pfam16101"
                     /db_xref="CDD:406495"
     CDS             1..153
                     /gene="PRIMA1"
                     /gene_synonym="PRIMA"
                     /coded_by="XM_011536456.3:462..923"
                     /db_xref="GeneID:145270"
                     /db_xref="HGNC:HGNC:18319"
                     /db_xref="MIM:613851"
ORIGIN      
        1 mllrdlvlrr gccwsslllh calhplwgfv qvthgepqks cskvtdscrh vcqcrppppl
       61 pppppppppp rllsapapns tscpteesww sglviiiavc caslvfltvl viicykaikr
      121 kplrkdengt svaeypmsas qsnkgvdvnn avv
//
LOCUS       XP_047286922             123 aa            linear   PRI 05-AUG-2025
DEFINITION  proline-rich membrane anchor 1 isoform X2 [Homo sapiens].
ACCESSION   XP_047286922
VERSION     XP_047286922.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430966.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..123
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..123
                     /product="proline-rich membrane anchor 1 isoform X2"
                     /calculated_mol_wt=13330
     Region          37..>119
                     /region_name="PRIMA1"
                     /note="Proline-rich membrane anchor 1; pfam16101"
                     /db_xref="CDD:406495"
     CDS             1..123
                     /gene="PRIMA1"
                     /gene_synonym="PRIMA"
                     /coded_by="XM_047430966.1:462..833"
                     /db_xref="GeneID:145270"
                     /db_xref="HGNC:HGNC:18319"
                     /db_xref="MIM:613851"
ORIGIN      
        1 mllrdlvlrr gccwsslllh calhplwgfv qvthgepqks cskvtdscrh vcqcrppppl
       61 pppppppppp rllsapapns tscpteesww sglviiiavc caslvfltvl viicykaiks
      121 les
//
LOCUS       XP_005267411             410 aa            linear   PRI 05-AUG-2025
DEFINITION  protein phosphatase 1 regulatory subunit 36 isoform X1 [Homo
            sapiens].
ACCESSION   XP_005267411
VERSION     XP_005267411.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267354.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..410
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..410
                     /product="protein phosphatase 1 regulatory subunit 36
                     isoform X1"
                     /calculated_mol_wt=47851
     Region          67..401
                     /region_name="PPPI_inhib"
                     /note="Protein phosphatase 1 inhibitor; pfam14895"
                     /db_xref="CDD:464358"
     CDS             1..410
                     /gene="PPP1R36"
                     /gene_synonym="C14orf50"
                     /coded_by="XM_005267354.5:60..1292"
                     /db_xref="GeneID:145376"
                     /db_xref="HGNC:HGNC:20097"
                     /db_xref="MIM:619923"
ORIGIN      
        1 mvriefwlpa qqlglrlgmw ywkdetrtle frrfaaedsv qwllkhhphf tpaaevkekg
       61 kkgkavhfae tdgpasdrlt dkrlaakddk sakavekrgq qgtitlddvk fvtllllqdt
      121 emqricsftt fmrnknldnf lmallyylsh yleknslekk pksymvglve kkemelvlse
      181 leaaqrylaq kycilvlgla vpdkhhmccg kekisdtqkd wkffesfytf ctyvawivfr
      241 rqhlteieee vgrlfrtnmf niprrrrede esggekkrmt fvqfrrmmak rpaikkainm
      301 rspvmstllp slrekaqnvf ekkyhqvdvr fpaemqkhvg tldsvpmpvv gilgeprclf
      361 nphtlhpldp eentksfgry pslmennnmr iqdtldlvmk tlsshtscpk
//
LOCUS       XP_005267412             378 aa            linear   PRI 05-AUG-2025
DEFINITION  protein phosphatase 1 regulatory subunit 36 isoform X2 [Homo
            sapiens].
ACCESSION   XP_005267412
VERSION     XP_005267412.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267355.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..378
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..378
                     /product="protein phosphatase 1 regulatory subunit 36
                     isoform X2"
                     /calculated_mol_wt=43773
     Region          35..369
                     /region_name="PPPI_inhib"
                     /note="Protein phosphatase 1 inhibitor; pfam14895"
                     /db_xref="CDD:464358"
     CDS             1..378
                     /gene="PPP1R36"
                     /gene_synonym="C14orf50"
                     /coded_by="XM_005267355.5:105..1241"
                     /db_xref="GeneID:145376"
                     /db_xref="HGNC:HGNC:20097"
                     /db_xref="MIM:619923"
ORIGIN      
        1 mfaaedsvqw llkhhphftp aaevkekgkk gkavhfaetd gpasdrltdk rlaakddksa
       61 kavekrgqqg titlddvkfv tllllqdtem qricsfttfm rnknldnflm allyylshyl
      121 eknslekkpk symvglvekk emelvlsele aaqrylaqky cilvlglavp dkhhmccgke
      181 kisdtqkdwk ffesfytfct yvawivfrrq hlteieeevg rlfrtnmfni prrrredees
      241 ggekkrmtfv qfrrmmakrp aikkainmrs pvmstllpsl rekaqnvfek kyhqvdvrfp
      301 aemqkhvgtl dsvpmpvvgi lgeprclfnp htlhpldpee ntksfgryps lmennnmriq
      361 dtldlvmktl sshtscpk
//
LOCUS       XP_011534770             377 aa            linear   PRI 05-AUG-2025
DEFINITION  protein phosphatase 1 regulatory subunit 36 isoform X3 [Homo
            sapiens].
ACCESSION   XP_011534770
VERSION     XP_011534770.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536468.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..377
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..377
                     /product="protein phosphatase 1 regulatory subunit 36
                     isoform X3"
                     /calculated_mol_wt=44268
     Region          79..368
                     /region_name="PPPI_inhib"
                     /note="Protein phosphatase 1 inhibitor; pfam14895"
                     /db_xref="CDD:464358"
     CDS             1..377
                     /gene="PPP1R36"
                     /gene_synonym="C14orf50"
                     /coded_by="XM_011536468.4:38..1171"
                     /db_xref="GeneID:145376"
                     /db_xref="HGNC:HGNC:20097"
                     /db_xref="MIM:619923"
ORIGIN      
        1 myrvpefyar rkrlggqtpy lmdqlglrlg mwywkdetrt lefrrfaaed svqwllkhhp
       61 hftpaaevke kgkkgkavhf aetdgpasdr ltdkrlaakd dksakavekr gqqgtitldd
      121 vkfvtllllq dtemqricsf ttfmrnknld nflmallyyl shyleknsle kkpksymvek
      181 isdtqkdwkf fesfytfcty vawivfrrqh lteieeevgr lfrtnmfnip rrrredeesg
      241 gekkrmtfvq frrmmakrpa ikkainmrsp vmstllpslr ekaqnvfekk yhqvdvrfpa
      301 emqkhvgtld svpmpvvgil geprclfnph tlhpldpeen tksfgrypsl mennnmriqd
      361 tldlvmktls shtscpk
//
LOCUS       XP_047286954             289 aa            linear   PRI 05-AUG-2025
DEFINITION  protein phosphatase 1 regulatory subunit 36 isoform X4 [Homo
            sapiens].
ACCESSION   XP_047286954
VERSION     XP_047286954.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430998.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..289
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..289
                     /product="protein phosphatase 1 regulatory subunit 36
                     isoform X4"
                     /calculated_mol_wt=33935
     Region          1..280
                     /region_name="PPPI_inhib"
                     /note="Protein phosphatase 1 inhibitor; pfam14895"
                     /db_xref="CDD:464358"
     CDS             1..289
                     /gene="PPP1R36"
                     /gene_synonym="C14orf50"
                     /coded_by="XM_047430998.1:491..1360"
                     /db_xref="GeneID:145376"
                     /db_xref="HGNC:HGNC:20097"
                     /db_xref="MIM:619923"
ORIGIN      
        1 mqricsfttf mrnknldnfl mallyylshy leknslekkp ksymvglvek kemelvlsel
       61 eaaqrylaqk ycilvlglav pdkhhmccgk ekisdtqkdw kffesfytfc tyvawivfrr
      121 qhlteieeev grlfrtnmfn iprrrredee sggekkrmtf vqfrrmmakr paikkainmr
      181 spvmstllps lrekaqnvfe kkyhqvdvrf paemqkhvgt ldsvpmpvvg ilgeprclfn
      241 phtlhpldpe entksfgryp slmennnmri qdtldlvmkt lsshtscpk
//
LOCUS       XP_047286955             289 aa            linear   PRI 05-AUG-2025
DEFINITION  protein phosphatase 1 regulatory subunit 36 isoform X4 [Homo
            sapiens].
ACCESSION   XP_047286955
VERSION     XP_047286955.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047430999.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..289
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..289
                     /product="protein phosphatase 1 regulatory subunit 36
                     isoform X4"
                     /calculated_mol_wt=33935
     Region          1..280
                     /region_name="PPPI_inhib"
                     /note="Protein phosphatase 1 inhibitor; pfam14895"
                     /db_xref="CDD:464358"
     CDS             1..289
                     /gene="PPP1R36"
                     /gene_synonym="C14orf50"
                     /coded_by="XM_047430999.1:426..1295"
                     /db_xref="GeneID:145376"
                     /db_xref="HGNC:HGNC:20097"
                     /db_xref="MIM:619923"
ORIGIN      
        1 mqricsfttf mrnknldnfl mallyylshy leknslekkp ksymvglvek kemelvlsel
       61 eaaqrylaqk ycilvlglav pdkhhmccgk ekisdtqkdw kffesfytfc tyvawivfrr
      121 qhlteieeev grlfrtnmfn iprrrredee sggekkrmtf vqfrrmmakr paikkainmr
      181 spvmstllps lrekaqnvfe kkyhqvdvrf paemqkhvgt ldsvpmpvvg ilgeprclfn
      241 phtlhpldpe entksfgryp slmennnmri qdtldlvmkt lsshtscpk
//
LOCUS       XP_047286956             289 aa            linear   PRI 05-AUG-2025
DEFINITION  protein phosphatase 1 regulatory subunit 36 isoform X4 [Homo
            sapiens].
ACCESSION   XP_047286956
VERSION     XP_047286956.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431000.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..289
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..289
                     /product="protein phosphatase 1 regulatory subunit 36
                     isoform X4"
                     /calculated_mol_wt=33935
     Region          1..280
                     /region_name="PPPI_inhib"
                     /note="Protein phosphatase 1 inhibitor; pfam14895"
                     /db_xref="CDD:464358"
     CDS             1..289
                     /gene="PPP1R36"
                     /gene_synonym="C14orf50"
                     /coded_by="XM_047431000.1:324..1193"
                     /db_xref="GeneID:145376"
                     /db_xref="HGNC:HGNC:20097"
                     /db_xref="MIM:619923"
ORIGIN      
        1 mqricsfttf mrnknldnfl mallyylshy leknslekkp ksymvglvek kemelvlsel
       61 eaaqrylaqk ycilvlglav pdkhhmccgk ekisdtqkdw kffesfytfc tyvawivfrr
      121 qhlteieeev grlfrtnmfn iprrrredee sggekkrmtf vqfrrmmakr paikkainmr
      181 spvmstllps lrekaqnvfe kkyhqvdvrf paemqkhvgt ldsvpmpvvg ilgeprclfn
      241 phtlhpldpe entksfgryp slmennnmri qdtldlvmkt lsshtscpk
//
LOCUS       XP_016876509             459 aa            linear   PRI 05-AUG-2025
DEFINITION  solute carrier family 38 member 6 isoform X1 [Homo sapiens].
ACCESSION   XP_016876509
VERSION     XP_016876509.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021020.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..459
                     /product="solute carrier family 38 member 6 isoform X1"
                     /calculated_mol_wt=50953
     Region          46..429
                     /region_name="SLC5-6-like_sbd"
                     /note="Solute carrier families 5 and 6-like; solute
                     binding domain; cl00456"
                     /db_xref="CDD:444915"
     CDS             1..459
                     /gene="SLC38A6"
                     /gene_synonym="NAT-1; SNAT6"
                     /coded_by="XM_017021020.2:34..1413"
                     /db_xref="GeneID:145389"
                     /db_xref="HGNC:HGNC:19863"
                     /db_xref="MIM:616518"
ORIGIN      
        1 measwgsfna ergwyvsvqq peeaeaeels pllsnelhrq rspgvsfgls vfnlmnaimg
       61 sgilglayvl antgvfgfsf llltvallas ysvhlllsmc iqtavtsyed lglfafglpg
      121 klvvagtiii qnigamssyl liiktelpaa iaefltgdys rywyldgqtl liiicvgivf
      181 plallpkigf lgytsslsff fmmffalvvi ikkwsipcpl tlnyvekgfq isnvtddckp
      241 klfhfskesa yalptmafsf lchtsilpiy celqspskkr mqnvtntaia lsfliyfisa
      301 lfgyltfydk vesellkgys kylshdvvvm tvklcilfav lltvplihfp arkavtmmff
      361 snfpfswirh flitlalnii ivllaiyvpd irnvfgvvga ststclifif pglfylklsr
      421 edflswkklg vgvqwcdlss lqplppglkq sshlslqss
//
LOCUS       XP_047286957             459 aa            linear   PRI 05-AUG-2025
DEFINITION  solute carrier family 38 member 6 isoform X1 [Homo sapiens].
ACCESSION   XP_047286957
VERSION     XP_047286957.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431001.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..459
                     /product="solute carrier family 38 member 6 isoform X1"
                     /calculated_mol_wt=50953
     Region          46..429
                     /region_name="SLC5-6-like_sbd"
                     /note="Solute carrier families 5 and 6-like; solute
                     binding domain; cl00456"
                     /db_xref="CDD:444915"
     CDS             1..459
                     /gene="SLC38A6"
                     /gene_synonym="NAT-1; SNAT6"
                     /coded_by="XM_047431001.1:34..1413"
                     /db_xref="GeneID:145389"
                     /db_xref="HGNC:HGNC:19863"
                     /db_xref="MIM:616518"
ORIGIN      
        1 measwgsfna ergwyvsvqq peeaeaeels pllsnelhrq rspgvsfgls vfnlmnaimg
       61 sgilglayvl antgvfgfsf llltvallas ysvhlllsmc iqtavtsyed lglfafglpg
      121 klvvagtiii qnigamssyl liiktelpaa iaefltgdys rywyldgqtl liiicvgivf
      181 plallpkigf lgytsslsff fmmffalvvi ikkwsipcpl tlnyvekgfq isnvtddckp
      241 klfhfskesa yalptmafsf lchtsilpiy celqspskkr mqnvtntaia lsfliyfisa
      301 lfgyltfydk vesellkgys kylshdvvvm tvklcilfav lltvplihfp arkavtmmff
      361 snfpfswirh flitlalnii ivllaiyvpd irnvfgvvga ststclifif pglfylklsr
      421 edflswkklg vgvqwcdlss lqplppglkq sshlslqss
//
LOCUS       XP_047286958             459 aa            linear   PRI 05-AUG-2025
DEFINITION  solute carrier family 38 member 6 isoform X1 [Homo sapiens].
ACCESSION   XP_047286958
VERSION     XP_047286958.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431002.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..459
                     /product="solute carrier family 38 member 6 isoform X1"
                     /calculated_mol_wt=50953
     Region          46..429
                     /region_name="SLC5-6-like_sbd"
                     /note="Solute carrier families 5 and 6-like; solute
                     binding domain; cl00456"
                     /db_xref="CDD:444915"
     CDS             1..459
                     /gene="SLC38A6"
                     /gene_synonym="NAT-1; SNAT6"
                     /coded_by="XM_047431002.1:34..1413"
                     /db_xref="GeneID:145389"
                     /db_xref="HGNC:HGNC:19863"
                     /db_xref="MIM:616518"
ORIGIN      
        1 measwgsfna ergwyvsvqq peeaeaeels pllsnelhrq rspgvsfgls vfnlmnaimg
       61 sgilglayvl antgvfgfsf llltvallas ysvhlllsmc iqtavtsyed lglfafglpg
      121 klvvagtiii qnigamssyl liiktelpaa iaefltgdys rywyldgqtl liiicvgivf
      181 plallpkigf lgytsslsff fmmffalvvi ikkwsipcpl tlnyvekgfq isnvtddckp
      241 klfhfskesa yalptmafsf lchtsilpiy celqspskkr mqnvtntaia lsfliyfisa
      301 lfgyltfydk vesellkgys kylshdvvvm tvklcilfav lltvplihfp arkavtmmff
      361 snfpfswirh flitlalnii ivllaiyvpd irnvfgvvga ststclifif pglfylklsr
      421 edflswkklg vgvqwcdlss lqplppglkq sshlslqss
//
LOCUS       XP_016876510             441 aa            linear   PRI 05-AUG-2025
DEFINITION  solute carrier family 38 member 6 isoform X2 [Homo sapiens].
ACCESSION   XP_016876510
VERSION     XP_016876510.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021021.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..441
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..441
                     /product="solute carrier family 38 member 6 isoform X2"
                     /calculated_mol_wt=48862
     Region          46..411
                     /region_name="SLC5-6-like_sbd"
                     /note="Solute carrier families 5 and 6-like; solute
                     binding domain; cl00456"
                     /db_xref="CDD:444915"
     CDS             1..441
                     /gene="SLC38A6"
                     /gene_synonym="NAT-1; SNAT6"
                     /coded_by="XM_017021021.2:34..1359"
                     /db_xref="GeneID:145389"
                     /db_xref="HGNC:HGNC:19863"
                     /db_xref="MIM:616518"
ORIGIN      
        1 measwgsfna ergwyvsvqq peeaeaeels pllsnelhrq rspgvsfgls vfnlmnaimg
       61 sgilglayvl antgvfgfsf llltvallas ysvhlllsmc iqtavtsyed lglfafglpg
      121 klvvagtiii qnigamssyl liiktelpaa iaefltgdys rywyldgqtl liiicvgivf
      181 plallpkigf lgytsslsff fmmffalvvi ikkwsipcpl tlnyvekgfq sayalptmaf
      241 sflchtsilp iycelqspsk krmqnvtnta ialsfliyfi salfgyltfy dkvesellkg
      301 yskylshdvv vmtvklcilf avlltvplih fparkavtmm ffsnfpfswi rhflitlaln
      361 iiivllaiyv pdirnvfgvv gaststclif ifpglfylkl sredflswkk lgvgvqwcdl
      421 sslqplppgl kqsshlslqs s
//
LOCUS       XP_047286959             441 aa            linear   PRI 05-AUG-2025
DEFINITION  solute carrier family 38 member 6 isoform X2 [Homo sapiens].
ACCESSION   XP_047286959
VERSION     XP_047286959.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431003.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..441
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..441
                     /product="solute carrier family 38 member 6 isoform X2"
                     /calculated_mol_wt=48862
     Region          46..411
                     /region_name="SLC5-6-like_sbd"
                     /note="Solute carrier families 5 and 6-like; solute
                     binding domain; cl00456"
                     /db_xref="CDD:444915"
     CDS             1..441
                     /gene="SLC38A6"
                     /gene_synonym="NAT-1; SNAT6"
                     /coded_by="XM_047431003.1:34..1359"
                     /db_xref="GeneID:145389"
                     /db_xref="HGNC:HGNC:19863"
                     /db_xref="MIM:616518"
ORIGIN      
        1 measwgsfna ergwyvsvqq peeaeaeels pllsnelhrq rspgvsfgls vfnlmnaimg
       61 sgilglayvl antgvfgfsf llltvallas ysvhlllsmc iqtavtsyed lglfafglpg
      121 klvvagtiii qnigamssyl liiktelpaa iaefltgdys rywyldgqtl liiicvgivf
      181 plallpkigf lgytsslsff fmmffalvvi ikkwsipcpl tlnyvekgfq sayalptmaf
      241 sflchtsilp iycelqspsk krmqnvtnta ialsfliyfi salfgyltfy dkvesellkg
      301 yskylshdvv vmtvklcilf avlltvplih fparkavtmm ffsnfpfswi rhflitlaln
      361 iiivllaiyv pdirnvfgvv gaststclif ifpglfylkl sredflswkk lgvgvqwcdl
      421 sslqplppgl kqsshlslqs s
//
LOCUS       XP_047286960             438 aa            linear   PRI 05-AUG-2025
DEFINITION  solute carrier family 38 member 6 isoform X3 [Homo sapiens].
ACCESSION   XP_047286960
VERSION     XP_047286960.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431004.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..438
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..438
                     /product="solute carrier family 38 member 6 isoform X3"
                     /calculated_mol_wt=48707
     Region          46..433
                     /region_name="SLC5-6-like_sbd"
                     /note="Solute carrier families 5 and 6-like; solute
                     binding domain; cl00456"
                     /db_xref="CDD:444915"
     CDS             1..438
                     /gene="SLC38A6"
                     /gene_synonym="NAT-1; SNAT6"
                     /coded_by="XM_047431004.1:34..1350"
                     /db_xref="GeneID:145389"
                     /db_xref="HGNC:HGNC:19863"
                     /db_xref="MIM:616518"
ORIGIN      
        1 measwgsfna ergwyvsvqq peeaeaeels pllsnelhrq rspgvsfgls vfnlmnaimg
       61 sgilglayvl antgvfgfsf llltvallas ysvhlllsmc iqtavtsyed lglfafglpg
      121 klvvagtiii qnigamssyl liiktelpaa iaefltgdys rywyldgqtl liiicvgivf
      181 plallpkigf lgytsslsff fmmffalvvi ikkwsipcpl tlnyvekgfq sayalptmaf
      241 sflchtsilp iycelqspsk krmqnvtnta ialsfliyfi salfgyltfy dkvesellkg
      301 yskylshdvv vmtvklcilf avlltvplih fparkavtmm ffsnfpfswi rhflitlaln
      361 iiivllaiyv pdirnvfgvv gaststclif ifpglfylkl sredflswkk lgafvllifg
      421 ilvgnfslal iifdwink
//
LOCUS       XP_016876511             436 aa            linear   PRI 05-AUG-2025
DEFINITION  solute carrier family 38 member 6 isoform X4 [Homo sapiens].
ACCESSION   XP_016876511
VERSION     XP_016876511.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021022.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..436
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..436
                     /product="solute carrier family 38 member 6 isoform X4"
                     /calculated_mol_wt=48391
     Region          23..406
                     /region_name="SLC5-6-like_sbd"
                     /note="Solute carrier families 5 and 6-like; solute
                     binding domain; cl00456"
                     /db_xref="CDD:444915"
     CDS             1..436
                     /gene="SLC38A6"
                     /gene_synonym="NAT-1; SNAT6"
                     /coded_by="XM_017021022.2:412..1722"
                     /db_xref="GeneID:145389"
                     /db_xref="HGNC:HGNC:19863"
                     /db_xref="MIM:616518"
ORIGIN      
        1 msgprimysl llelhrqrsp gvsfglsvfn lmnaimgsgi lglayvlant gvfgfsflll
       61 tvallasysv hlllsmciqt avtsyedlgl fafglpgklv vagtiiiqni gamssyllii
      121 ktelpaaiae fltgdysryw yldgqtllii icvgivfpla llpkigflgy tsslsfffmm
      181 ffalvviikk wsipcpltln yvekgfqisn vtddckpklf hfskesayal ptmafsflch
      241 tsilpiycel qspskkrmqn vtntaialsf liyfisalfg yltfydkves ellkgyskyl
      301 shdvvvmtvk lcilfavllt vplihfpark avtmmffsnf pfswirhfli tlalniiivl
      361 laiyvpdirn vfgvvgasts tclififpgl fylklsredf lswkklgvgv qwcdlsslqp
      421 lppglkqssh lslqss
//
LOCUS       XP_016876512             435 aa            linear   PRI 05-AUG-2025
DEFINITION  solute carrier family 38 member 6 isoform X5 [Homo sapiens].
ACCESSION   XP_016876512
VERSION     XP_016876512.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021023.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..435
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..435
                     /product="solute carrier family 38 member 6 isoform X5"
                     /calculated_mol_wt=48457
     Region          46..429
                     /region_name="SLC5-6-like_sbd"
                     /note="Solute carrier families 5 and 6-like; solute
                     binding domain; cl00456"
                     /db_xref="CDD:444915"
     CDS             1..435
                     /gene="SLC38A6"
                     /gene_synonym="NAT-1; SNAT6"
                     /coded_by="XM_017021023.2:34..1341"
                     /db_xref="GeneID:145389"
                     /db_xref="HGNC:HGNC:19863"
                     /db_xref="MIM:616518"
ORIGIN      
        1 measwgsfna ergwyvsvqq peeaeaeels pllsnelhrq rspgvsfgls vfnlmnaimg
       61 sgilglayvl antgvfgfsf llltvallas ysvhlllsmc iqtavtsyed lglfafglpg
      121 klvvagtiii qnigamssyl liiktelpaa iaefltgdys rywyldgqtl liiicvgivf
      181 plallpkigf lgytsslsff fmmffalvvi ikkwsipcpl tlnyvekgfq isnvtddckp
      241 klfhfskesa yalptmafsf lchtsilpiy celqspskkr mqnvtntaia lsfliyfisa
      301 lfgyltfydk vesellkgys kylshdvvvm tvklcilfav lltvplihfp arkavtmmff
      361 snfpfswirh flitlalnii ivllaiyvpd irnvfgvvga ststclifif pglfylklsr
      421 edflswkklg vqgym
//
LOCUS       XP_047286961             433 aa            linear   PRI 05-AUG-2025
DEFINITION  solute carrier family 38 member 6 isoform X6 [Homo sapiens].
ACCESSION   XP_047286961
VERSION     XP_047286961.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431005.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..433
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..433
                     /product="solute carrier family 38 member 6 isoform X6"
                     /calculated_mol_wt=48236
     Region          23..428
                     /region_name="SLC5-6-like_sbd"
                     /note="Solute carrier families 5 and 6-like; solute
                     binding domain; cl00456"
                     /db_xref="CDD:444915"
     CDS             1..433
                     /gene="SLC38A6"
                     /gene_synonym="NAT-1; SNAT6"
                     /coded_by="XM_047431005.1:412..1713"
                     /db_xref="GeneID:145389"
                     /db_xref="HGNC:HGNC:19863"
                     /db_xref="MIM:616518"
ORIGIN      
        1 msgprimysl llelhrqrsp gvsfglsvfn lmnaimgsgi lglayvlant gvfgfsflll
       61 tvallasysv hlllsmciqt avtsyedlgl fafglpgklv vagtiiiqni gamssyllii
      121 ktelpaaiae fltgdysryw yldgqtllii icvgivfpla llpkigflgy tsslsfffmm
      181 ffalvviikk wsipcpltln yvekgfqisn vtddckpklf hfskesayal ptmafsflch
      241 tsilpiycel qspskkrmqn vtntaialsf liyfisalfg yltfydkves ellkgyskyl
      301 shdvvvmtvk lcilfavllt vplihfpark avtmmffsnf pfswirhfli tlalniiivl
      361 laiyvpdirn vfgvvgasts tclififpgl fylklsredf lswkklgafv llifgilvgn
      421 fslaliifdw ink
//
LOCUS       XP_047286962             415 aa            linear   PRI 05-AUG-2025
DEFINITION  solute carrier family 38 member 6 isoform X7 [Homo sapiens].
ACCESSION   XP_047286962
VERSION     XP_047286962.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431006.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..415
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..415
                     /product="solute carrier family 38 member 6 isoform X7"
                     /calculated_mol_wt=46146
     Region          23..410
                     /region_name="SLC5-6-like_sbd"
                     /note="Solute carrier families 5 and 6-like; solute
                     binding domain; cl00456"
                     /db_xref="CDD:444915"
     CDS             1..415
                     /gene="SLC38A6"
                     /gene_synonym="NAT-1; SNAT6"
                     /coded_by="XM_047431006.1:412..1659"
                     /db_xref="GeneID:145389"
                     /db_xref="HGNC:HGNC:19863"
                     /db_xref="MIM:616518"
ORIGIN      
        1 msgprimysl llelhrqrsp gvsfglsvfn lmnaimgsgi lglayvlant gvfgfsflll
       61 tvallasysv hlllsmciqt avtsyedlgl fafglpgklv vagtiiiqni gamssyllii
      121 ktelpaaiae fltgdysryw yldgqtllii icvgivfpla llpkigflgy tsslsfffmm
      181 ffalvviikk wsipcpltln yvekgfqsay alptmafsfl chtsilpiyc elqspskkrm
      241 qnvtntaial sfliyfisal fgyltfydkv esellkgysk ylshdvvvmt vklcilfavl
      301 ltvplihfpa rkavtmmffs nfpfswirhf litlalniii vllaiyvpdi rnvfgvvgas
      361 tstclififp glfylklsre dflswkklga fvllifgilv gnfslaliif dwink
//
LOCUS       XP_016876514             405 aa            linear   PRI 05-AUG-2025
DEFINITION  solute carrier family 38 member 6 isoform X8 [Homo sapiens].
ACCESSION   XP_016876514
VERSION     XP_016876514.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021025.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..405
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..405
                     /product="solute carrier family 38 member 6 isoform X8"
                     /calculated_mol_wt=44903
     Region          2..375
                     /region_name="SLC5-6-like_sbd"
                     /note="Solute carrier families 5 and 6-like; solute
                     binding domain; cl00456"
                     /db_xref="CDD:444915"
     CDS             1..405
                     /gene="SLC38A6"
                     /gene_synonym="NAT-1; SNAT6"
                     /coded_by="XM_017021025.2:147..1364"
                     /db_xref="GeneID:145389"
                     /db_xref="HGNC:HGNC:19863"
                     /db_xref="MIM:616518"
ORIGIN      
        1 mnaimgsgil glayvlantg vfgfsflllt vallasysvh lllsmciqta vtsyedlglf
       61 afglpgklvv agtiiiqnig amssylliik telpaaiaef ltgdysrywy ldgqtlliii
      121 cvgivfplal lpkigflgyt sslsfffmmf falvviikkw sipcpltlny vekgfqisnv
      181 tddckpklfh fskesayalp tmafsflcht silpiycelq spskkrmqnv tntaialsfl
      241 iyfisalfgy ltfydkvese llkgyskyls hdvvvmtvkl cilfavlltv plihfparka
      301 vtmmffsnfp fswirhflit lalniiivll aiyvpdirnv fgvvgastst clififpglf
      361 ylklsredfl swkklgvgvq wcdlsslqpl ppglkqsshl slqss
//
LOCUS       XP_011534771             348 aa            linear   PRI 05-AUG-2025
DEFINITION  solute carrier family 38 member 6 isoform X9 [Homo sapiens].
ACCESSION   XP_011534771
VERSION     XP_011534771.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536469.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..348
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..348
                     /product="solute carrier family 38 member 6 isoform X9"
                     /calculated_mol_wt=38838
     Region          46..>309
                     /region_name="SLC5-6-like_sbd"
                     /note="Solute carrier families 5 and 6-like; solute
                     binding domain; cl00456"
                     /db_xref="CDD:444915"
     CDS             1..348
                     /gene="SLC38A6"
                     /gene_synonym="NAT-1; SNAT6"
                     /coded_by="XM_011536469.3:34..1080"
                     /db_xref="GeneID:145389"
                     /db_xref="HGNC:HGNC:19863"
                     /db_xref="MIM:616518"
ORIGIN      
        1 measwgsfna ergwyvsvqq peeaeaeels pllsnelhrq rspgvsfgls vfnlmnaimg
       61 sgilglayvl antgvfgfsf llltvallas ysvhlllsmc iqtavtsyed lglfafglpg
      121 klvvagtiii qnigamssyl liiktelpaa iaefltgdys rywyldgqtl liiicvgivf
      181 plallpkigf lgytsslsff fmmffalvvi ikkwsipcpl tlnyvekgfq isnvtddckp
      241 klfhfskesa yalptmafsf lchtsilpiy celqspskkr mqnvtntaia lsfliyfisa
      301 lfgyltfyep qekvkfcvhh qekhyfqceh galletlqrk lkqivklf
//
LOCUS       XP_047286963             324 aa            linear   PRI 05-AUG-2025
DEFINITION  solute carrier family 38 member 6 isoform X10 [Homo sapiens].
ACCESSION   XP_047286963
VERSION     XP_047286963.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431007.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..324
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..324
                     /product="solute carrier family 38 member 6 isoform X10"
                     /calculated_mol_wt=36554
     Region          <1..294
                     /region_name="SLC5-6-like_sbd"
                     /note="Solute carrier families 5 and 6-like; solute
                     binding domain; cl00456"
                     /db_xref="CDD:444915"
     CDS             1..324
                     /gene="SLC38A6"
                     /gene_synonym="NAT-1; SNAT6"
                     /coded_by="XM_047431007.1:281..1255"
                     /db_xref="GeneID:145389"
                     /db_xref="HGNC:HGNC:19863"
                     /db_xref="MIM:616518"
ORIGIN      
        1 mssylliikt elpaaiaefl tgdysrywyl dgqtlliiic vgivfplall pkigflgyts
       61 slsfffmmff alvviikkws ipcpltlnyv ekgfqisnvt ddckpklfhf skesayalpt
      121 mafsflchts ilpiycelqs pskkrmqnvt ntaialsfli yfisalfgyl tfydkvesel
      181 lkgyskylsh dvvvmtvklc ilfavlltvp lihfparkav tmmffsnfpf swirhflitl
      241 alniiivlla iyvpdirnvf gvvgaststc lififpglfy lklsredfls wkklgvgvqw
      301 cdlsslqplp pglkqsshls lqss
//
LOCUS       XP_047286964             318 aa            linear   PRI 05-AUG-2025
DEFINITION  solute carrier family 38 member 6 isoform X11 [Homo sapiens].
ACCESSION   XP_047286964
VERSION     XP_047286964.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431008.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..318
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..318
                     /product="solute carrier family 38 member 6 isoform X11"
                     /calculated_mol_wt=35187
     Region          46..>310
                     /region_name="SLC5-6-like_sbd"
                     /note="Solute carrier families 5 and 6-like; solute
                     binding domain; cl00456"
                     /db_xref="CDD:444915"
     CDS             1..318
                     /gene="SLC38A6"
                     /gene_synonym="NAT-1; SNAT6"
                     /coded_by="XM_047431008.1:34..990"
                     /db_xref="GeneID:145389"
                     /db_xref="HGNC:HGNC:19863"
                     /db_xref="MIM:616518"
ORIGIN      
        1 measwgsfna ergwyvsvqq peeaeaeels pllsnelhrq rspgvsfgls vfnlmnaimg
       61 sgilglayvl antgvfgfsf llltvallas ysvhlllsmc iqtavtsyed lglfafglpg
      121 klvvagtiii qnigamssyl liiktelpaa iaefltgdys rywyldgqtl liiicvgivf
      181 plallpkigf lgytsslsff fmmffalvvi ikkwsipcpl tlnyvekgfq isnvtddckp
      241 klfhfskesa yalptmafsf lchtsilpiy celqspskkr mqnvtntaia lsfliyfisa
      301 lfgyltfyde qlkprevk
//
LOCUS       XP_047286965             311 aa            linear   PRI 05-AUG-2025
DEFINITION  solute carrier family 38 member 6 isoform X12 [Homo sapiens].
ACCESSION   XP_047286965
VERSION     XP_047286965.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431009.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..311
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..311
                     /product="solute carrier family 38 member 6 isoform X12"
                     /calculated_mol_wt=34309
     Region          46..>311
                     /region_name="SLC5-6-like_sbd"
                     /note="Solute carrier families 5 and 6-like; solute
                     binding domain; cl00456"
                     /db_xref="CDD:444915"
     CDS             1..311
                     /gene="SLC38A6"
                     /gene_synonym="NAT-1; SNAT6"
                     /coded_by="XM_047431009.1:34..969"
                     /db_xref="GeneID:145389"
                     /db_xref="HGNC:HGNC:19863"
                     /db_xref="MIM:616518"
ORIGIN      
        1 measwgsfna ergwyvsvqq peeaeaeels pllsnelhrq rspgvsfgls vfnlmnaimg
       61 sgilglayvl antgvfgfsf llltvallas ysvhlllsmc iqtavtsyed lglfafglpg
      121 klvvagtiii qnigamssyl liiktelpaa iaefltgdys rywyldgqtl liiicvgivf
      181 plallpkigf lgytsslsff fmmffalvvi ikkwsipcpl tlnyvekgfq isnvtddckp
      241 klfhfskesa yalptmafsf lchtsilpiy celqspskkr mqnvtntaia lsfliyfisa
      301 lfgyltfyde t
//
LOCUS       XP_047286966             309 aa            linear   PRI 05-AUG-2025
DEFINITION  solute carrier family 38 member 6 isoform X13 [Homo sapiens].
ACCESSION   XP_047286966
VERSION     XP_047286966.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431010.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..309
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..309
                     /product="solute carrier family 38 member 6 isoform X13"
                     /calculated_mol_wt=34021
     Region          46..>308
                     /region_name="SLC5-6-like_sbd"
                     /note="Solute carrier families 5 and 6-like; solute
                     binding domain; cl00456"
                     /db_xref="CDD:444915"
     CDS             1..309
                     /gene="SLC38A6"
                     /gene_synonym="NAT-1; SNAT6"
                     /coded_by="XM_047431010.1:34..963"
                     /db_xref="GeneID:145389"
                     /db_xref="HGNC:HGNC:19863"
                     /db_xref="MIM:616518"
ORIGIN      
        1 measwgsfna ergwyvsvqq peeaeaeels pllsnelhrq rspgvsfgls vfnlmnaimg
       61 sgilglayvl antgvfgfsf llltvallas ysvhlllsmc iqtavtsyed lglfafglpg
      121 klvvagtiii qnigamssyl liiktelpaa iaefltgdys rywyldgqtl liiicvgivf
      181 plallpkigf lgytsslsff fmmffalvvi ikkwsipcpl tlnyvekgfq isnvtddckp
      241 klfhfskesa yalptmafsf lchtsilpiy celqspskkr mqnvtntaia lsfliyfisa
      301 lfgyltfyg
//
LOCUS       XP_024305264             258 aa            linear   PRI 05-AUG-2025
DEFINITION  solute carrier family 38 member 6 isoform X14 [Homo sapiens].
ACCESSION   XP_024305264
VERSION     XP_024305264.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449496.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..258
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..258
                     /product="solute carrier family 38 member 6 isoform X14"
                     /calculated_mol_wt=29156
     Region          <3..228
                     /region_name="SLC5-6-like_sbd"
                     /note="Solute carrier families 5 and 6-like; solute
                     binding domain; cl00456"
                     /db_xref="CDD:444915"
     CDS             1..258
                     /gene="SLC38A6"
                     /gene_synonym="NAT-1; SNAT6"
                     /coded_by="XM_024449496.2:648..1424"
                     /db_xref="GeneID:145389"
                     /db_xref="HGNC:HGNC:19863"
                     /db_xref="MIM:616518"
ORIGIN      
        1 mmffalvvii kkwsipcplt lnyvekgfqi snvtddckpk lfhfskesay alptmafsfl
       61 chtsilpiyc elqspskkrm qnvtntaial sfliyfisal fgyltfydkv esellkgysk
      121 ylshdvvvmt vklcilfavl ltvplihfpa rkavtmmffs nfpfswirhf litlalniii
      181 vllaiyvpdi rnvfgvvgas tstclififp glfylklsre dflswkklgv gvqwcdlssl
      241 qplppglkqs shlslqss
//
LOCUS       XP_011534776             320 aa            linear   PRI 05-AUG-2025
DEFINITION  protein ABHD12B isoform X1 [Homo sapiens].
ACCESSION   XP_011534776
VERSION     XP_011534776.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536474.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..320
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..320
                     /product="protein ABHD12B isoform X1"
                     /calculated_mol_wt=36028
     Region          <36..>127
                     /region_name="PTZ00360"
                     /note="sexual stage antigen; Provisional"
                     /db_xref="CDD:240379"
     Region          88..301
                     /region_name="FrsA"
                     /note="Fermentation-respiration switch esterase FrsA,
                     DUF1100 family [Signal transduction mechanisms]; COG1073"
                     /db_xref="CDD:440691"
     CDS             1..320
                     /gene="ABHD12B"
                     /gene_synonym="BEM46L3; C14orf29; c14_5314"
                     /coded_by="XM_011536474.3:132..1094"
                     /db_xref="GeneID:145447"
                     /db_xref="HGNC:HGNC:19837"
ORIGIN      
        1 mlgrkiaaly dsftskslke hvflplidml iyfnffkapf lvdlkkpelk iphtvnfylr
       61 vepgvmlgiw htvpscrged akgkdccwye aalrdgnpii vylhgsaehr aashrlklvk
      121 vlsdggfhvl svdyrgfgds tgkpteeglt tdaicvyewt karsgitpvc lwghslgtgv
      181 atnaakvlee kgcpvdaivl eapftnmwva sinypllkiy rnipgflrtl mdalrkdkii
      241 fpndenvkfl sspllilhge ddrtvpleyg kklyeiarna yrnkervkmv ifppgfqhnl
      301 lcksptllit vrdflskqws
//
LOCUS       XP_011534774             266 aa            linear   PRI 05-AUG-2025
DEFINITION  protein ABHD12B isoform X2 [Homo sapiens].
ACCESSION   XP_011534774
VERSION     XP_011534774.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536472.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..266
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..266
                     /product="protein ABHD12B isoform X2"
                     /calculated_mol_wt=29245
     Region          <78..>169
                     /region_name="PTZ00360"
                     /note="sexual stage antigen; Provisional"
                     /db_xref="CDD:240379"
     Region          130..>250
                     /region_name="FrsA"
                     /note="Fermentation-respiration switch esterase FrsA,
                     DUF1100 family [Signal transduction mechanisms]; COG1073"
                     /db_xref="CDD:440691"
     CDS             1..266
                     /gene="ABHD12B"
                     /gene_synonym="BEM46L3; C14orf29; c14_5314"
                     /coded_by="XM_011536472.2:123..923"
                     /db_xref="GeneID:145447"
                     /db_xref="HGNC:HGNC:19837"
ORIGIN      
        1 mdaqdcqaaa speppgppar scvaawwdmv drnlryfphs csmlgrkiaa lydsftsksl
       61 kehvflplid mliyfnffka pflvdlkkpe lkiphtvnfy lrvepgvmlg iwhtvpscrg
      121 edakgkdccw yeaalrdgnp iivylhgsae hraashrlkl vkvlsdggfh vlsvdyrgfg
      181 dstgkpteeg lttdaicvye wtkarsgitp vclwghslgt gvatnaakvl eekgcpvdai
      241 vleapftnmw vasinypllk vsaqma
//
LOCUS       XP_006720115             189 aa            linear   PRI 05-AUG-2025
DEFINITION  protein ABHD12B isoform X3 [Homo sapiens].
ACCESSION   XP_006720115
VERSION     XP_006720115.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720052.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..189
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..189
                     /product="protein ABHD12B isoform X3"
                     /calculated_mol_wt=20239
     Region          53..>173
                     /region_name="FrsA"
                     /note="Fermentation-respiration switch esterase FrsA,
                     DUF1100 family [Signal transduction mechanisms]; COG1073"
                     /db_xref="CDD:440691"
     CDS             1..189
                     /gene="ABHD12B"
                     /gene_synonym="BEM46L3; C14orf29; c14_5314"
                     /coded_by="XM_006720052.2:123..692"
                     /db_xref="GeneID:145447"
                     /db_xref="HGNC:HGNC:19837"
ORIGIN      
        1 mdaqdcqaaa speppgppar scvaawwdmv drnlrhtvps crgedakgkd ccwyeaalrd
       61 gnpiivylhg saehraashr lklvkvlsdg gfhvlsvdyr gfgdstgkpt eeglttdaic
      121 vyewtkarsg itpvclwghs lgtgvatnaa kvleekgcpv daivleapft nmwvasinyp
      181 llkvsaqma
//
LOCUS       XP_016876520             159 aa            linear   PRI 05-AUG-2025
DEFINITION  protein ABHD12B isoform X4 [Homo sapiens].
ACCESSION   XP_016876520
VERSION     XP_016876520.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021031.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..159
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..159
                     /product="protein ABHD12B isoform X4"
                     /calculated_mol_wt=17045
     Region          23..>143
                     /region_name="FrsA"
                     /note="Fermentation-respiration switch esterase FrsA,
                     DUF1100 family [Signal transduction mechanisms]; COG1073"
                     /db_xref="CDD:440691"
     CDS             1..159
                     /gene="ABHD12B"
                     /gene_synonym="BEM46L3; C14orf29; c14_5314"
                     /coded_by="XM_017021031.2:316..795"
                     /db_xref="GeneID:145447"
                     /db_xref="HGNC:HGNC:19837"
ORIGIN      
        1 mlgiwhtvps crgedakgkd ccwyeaalrd gnpiivylhg saehraashr lklvkvlsdg
       61 gfhvlsvdyr gfgdstgkpt eeglttdaic vyewtkarsg itpvclwghs lgtgvatnaa
      121 kvleekgcpv daivleapft nmwvasinyp llkvsaqma
//
LOCUS       XP_011534777             643 aa            linear   PRI 05-AUG-2025
DEFINITION  protein FAM161B isoform X1 [Homo sapiens].
ACCESSION   XP_011534777
VERSION     XP_011534777.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536475.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XP_011534777.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..643
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..643
                     /product="protein FAM161B isoform X1"
                     /calculated_mol_wt=73095
     Region          167..536
                     /region_name="UPF0564"
                     /note="Uncharacterized protein family UPF0564; pfam10595"
                     /db_xref="CDD:431382"
     CDS             1..643
                     /gene="FAM161B"
                     /gene_synonym="C14orf44; c14_5547"
                     /coded_by="XM_011536475.3:69..2000"
                     /db_xref="GeneID:145483"
                     /db_xref="HGNC:HGNC:19854"
ORIGIN      
        1 mtvgrpegap ggaegsrqif ppesfadtea geelsgdglv lpraskldef lspeeeidst
       61 sdstgsiyqn lqelkqkgrw clleslfqsd pesdenlsed eedlesffqd kdrgmvqvqc
      121 pqalrcgstr rcsslnnlps niprpqtqpp sgsrppsqhr svsswassit vprpfrmtlr
      181 earkkaewlg spasfeqerq raqrqgeeea echrqfraqp vpahvylply qeimersear
      241 rqagiqkrke lllsslkpfs flekeeqlke aarqrdlaat aeakiskqka trripksile
      301 palgdklqea elfrkiriqm raldmlqmas spiasssnra npqprtatrt qqeklgflht
      361 nfrfqprvnp vvpdyeglyk afqrraakrr etqeatrnkp fllrtanlrh pqrpcdaatt
      421 grrqdspqpp atplprsrsl sglaslsant lpvhitdatr kresavrsal ekknkadesi
      481 qwleihkkks qamsksvtlr akamdphksl eevfkaklke nrnndrkrak eykkeleemk
      541 qriqtrpylf eqvakdlakk eaeqwyldtl kqagleedfv rnkgqgtrav qeketkikdf
      601 prfqettkls irdpeqgleg sleqpasprc vffggdrvti twa
//
LOCUS       XP_016876524             496 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 74A isoform X1 [Homo
            sapiens].
ACCESSION   XP_016876524
VERSION     XP_016876524.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021035.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..496
                     /product="leucine-rich repeat-containing protein 74A
                     isoform X1"
                     /calculated_mol_wt=55316
     Region          <75..339
                     /region_name="RNA1"
                     /note="Ran GTPase-activating protein (RanGAP) involved in
                     mRNA processing and transport [Translation, ribosomal
                     structure and biogenesis]; COG5238"
                     /db_xref="CDD:444072"
     Region          119..141
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          146..174
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          175..202
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          203..226
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          231..258
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          259..286
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     CDS             1..496
                     /gene="LRRC74A"
                     /gene_synonym="C14orf166B; LRRC74"
                     /coded_by="XM_017021035.3:291..1781"
                     /db_xref="GeneID:145497"
                     /db_xref="HGNC:HGNC:23346"
ORIGIN      
        1 mdndkplqpe tedeieiepv rqssdkmlyc eaespptvek vkparenset dleieddekf
       61 fttgqkelyl eacklmgvvp vsyfirnmee syvnlnhhgl gprgtkaiai alvsnmavtk
      121 leledncime egvlslveml qenyylqemn isnnhlgleg ariisdffer nsssiwslel
      181 sgndfkedsa allcqalstn yqikkldlsh nqfsdvggeh lgqmlainvg ltsldlswnn
      241 fhtrgavalc nglrgnvtlt kldlsmngfg nevalalgev lrlnrclvyl diggndigne
      301 gaskiskgle sneslrvlkl flnpinmdga illilaikrn pksrmeeldi snvlvseqfm
      361 ktldgvyavh pqldvvfkav qglspkktif lltnpmkliq syadqhkiti vdffkslnpt
      421 gtmkmsvdef qkvmieqnkv plnqyqvrev ikkldektgm vnfrsaqapr rspfsargpg
      481 wadflehdea iatslv
//
LOCUS       XP_047286968             489 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 74A isoform X2 [Homo
            sapiens].
ACCESSION   XP_047286968
VERSION     XP_047286968.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431012.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..489
                     /product="leucine-rich repeat-containing protein 74A
                     isoform X2"
                     /calculated_mol_wt=54603
     Region          <75..332
                     /region_name="RNA1"
                     /note="Ran GTPase-activating protein (RanGAP) involved in
                     mRNA processing and transport [Translation, ribosomal
                     structure and biogenesis]; COG5238"
                     /db_xref="CDD:444072"
     Region          119..141
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          146..174
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          175..202
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          203..226
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          231..252
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          253..279
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     CDS             1..489
                     /gene="LRRC74A"
                     /gene_synonym="C14orf166B; LRRC74"
                     /coded_by="XM_047431012.1:291..1760"
                     /db_xref="GeneID:145497"
                     /db_xref="HGNC:HGNC:23346"
ORIGIN      
        1 mdndkplqpe tedeieiepv rqssdkmlyc eaespptvek vkparenset dleieddekf
       61 fttgqkelyl eacklmgvvp vsyfirnmee syvnlnhhgl gprgtkaiai alvsnmavtk
      121 leledncime egvlslveml qenyylqemn isnnhlgleg ariisdffer nsssiwslel
      181 sgndfkedsa allcqalstn yqikkldlsh nqfsdvggeh lgqmlainvg ltsldlswnn
      241 fhtrgavalc nglrldlsmn gfgnevalal gevlrlnrcl vyldiggndi gnegaskisk
      301 glesneslrv lklflnpinm dgaillilai krnpksrmee ldisnvlvse qfmktldgvy
      361 avhpqldvvf kavqglspkk tiflltnpmk liqsyadqhk itivdffksl nptgtmkmsv
      421 defqkvmieq nkvplnqyqv revikkldek tgmvnfrsaq aprrspfsar gpgwadfleh
      481 deaiatslv
//
LOCUS       XP_047286969             452 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 74A isoform X3 [Homo
            sapiens].
ACCESSION   XP_047286969
VERSION     XP_047286969.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431013.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..452
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..452
                     /product="leucine-rich repeat-containing protein 74A
                     isoform X3"
                     /calculated_mol_wt=50497
     Region          <75..296
                     /region_name="RNA1"
                     /note="Ran GTPase-activating protein (RanGAP) involved in
                     mRNA processing and transport [Translation, ribosomal
                     structure and biogenesis]; COG5238"
                     /db_xref="CDD:444072"
     Region          92..117
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          119..141
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          146..173
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          187..214
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          215..234
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          243..270
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          271..289
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     CDS             1..452
                     /gene="LRRC74A"
                     /gene_synonym="C14orf166B; LRRC74"
                     /coded_by="XM_047431013.1:291..1649"
                     /db_xref="GeneID:145497"
                     /db_xref="HGNC:HGNC:23346"
ORIGIN      
        1 mdndkplqpe tedeieiepv rqssdkmlyc eaespptvek vkparenset dleieddekf
       61 fttgqkelyl eacklmgvvp vsyfirnmee syvnlnhhgl gprgtkaiai alvsnmavtk
      121 leledncime egvlslveml qenyylqemn isnnhlgleg ariisdffer nsssiwslel
      181 sainvgltsl dlswnnfhtr gavalcnglr gnvtltkldl smngfgneva lalgevlrln
      241 rclvyldigg ndignegask iskglesnes lrvlklflnp inmdgailli laikrnpksr
      301 meeldisnvl vseqfmktld gvyavhpqld vvfkavqgls pkktiflltn pmkliqsyad
      361 qhkitivdff kslnptgtmk msvdefqkvm ieqnkvplnq yqvrevikkl dektgmvnfr
      421 saqaprrspf sargpgwadf lehdeaiats lv
//
LOCUS       XP_047286970             294 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 74A isoform X4 [Homo
            sapiens].
ACCESSION   XP_047286970
VERSION     XP_047286970.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431014.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..294
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..294
                     /product="leucine-rich repeat-containing protein 74A
                     isoform X4"
                     /calculated_mol_wt=32655
     Region          <75..>249
                     /region_name="RNA1"
                     /note="Ran GTPase-activating protein (RanGAP) involved in
                     mRNA processing and transport [Translation, ribosomal
                     structure and biogenesis]; COG5238"
                     /db_xref="CDD:444072"
     Region          92..117
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          119..145
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          146..174
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          175..202
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          203..226
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          231..251
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     CDS             1..294
                     /gene="LRRC74A"
                     /gene_synonym="C14orf166B; LRRC74"
                     /coded_by="XM_047431014.1:291..1175"
                     /db_xref="GeneID:145497"
                     /db_xref="HGNC:HGNC:23346"
ORIGIN      
        1 mdndkplqpe tedeieiepv rqssdkmlyc eaespptvek vkparenset dleieddekf
       61 fttgqkelyl eacklmgvvp vsyfirnmee syvnlnhhgl gprgtkaiai alvsnmavtk
      121 leledncime egvlslveml qenyylqemn isnnhlgleg ariisdffer nsssiwslel
      181 sgndfkedsa allcqalstn yqikkldlsh nqfsdvggeh lgqmlainvg ltsldlswnn
      241 fhtrgavalc nglrgkssds taawstwisv amtsamkgpp ksakdwnpmk asef
//
LOCUS       XP_011534789             288 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 74A isoform X5 [Homo
            sapiens].
ACCESSION   XP_011534789
VERSION     XP_011534789.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536487.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XP_011534789.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..288
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..288
                     /product="leucine-rich repeat-containing protein 74A
                     isoform X5"
                     /calculated_mol_wt=31778
     Region          <69..>243
                     /region_name="RNA1"
                     /note="Ran GTPase-activating protein (RanGAP) involved in
                     mRNA processing and transport [Translation, ribosomal
                     structure and biogenesis]; COG5238"
                     /db_xref="CDD:444072"
     Region          86..111
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          113..139
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          140..168
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          169..196
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          197..220
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          225..245
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     CDS             1..288
                     /gene="LRRC74A"
                     /gene_synonym="C14orf166B; LRRC74"
                     /coded_by="XM_011536487.2:38..904"
                     /db_xref="GeneID:145497"
                     /db_xref="HGNC:HGNC:23346"
ORIGIN      
        1 mwqkglldfa wspppgwqgr aaaashachl pqeqcphvvl lkaesihkqd dekffttgqk
       61 elyleacklm gvvpvsyfir nmeesyvnln hhglgprgtk aiaialvsnm avtkleledn
      121 cimeegvlsl vemlqenyyl qemnisnnhl glegariisd ffernsssiw slelsgndfk
      181 edsaallcqa lstnyqikkl dlshnqfsdv ggehlgqmla invgltsldl swnnfhtrga
      241 valcnglrgk ssdstaawst wisvamtsam kgppksakdw npmkasef
//
LOCUS       XP_047286971             268 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 74A isoform X6 [Homo
            sapiens].
ACCESSION   XP_047286971
VERSION     XP_047286971.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431015.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..268
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..268
                     /product="leucine-rich repeat-containing protein 74A
                     isoform X6"
                     /calculated_mol_wt=29630
     Region          <49..>223
                     /region_name="RNA1"
                     /note="Ran GTPase-activating protein (RanGAP) involved in
                     mRNA processing and transport [Translation, ribosomal
                     structure and biogenesis]; COG5238"
                     /db_xref="CDD:444072"
     Region          66..91
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          93..119
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          120..148
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          149..176
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          177..200
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          205..225
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     CDS             1..268
                     /gene="LRRC74A"
                     /gene_synonym="C14orf166B; LRRC74"
                     /coded_by="XM_047431015.1:131..937"
                     /db_xref="GeneID:145497"
                     /db_xref="HGNC:HGNC:23346"
ORIGIN      
        1 mlyceaespp tvekvkpare nsetdleied dekffttgqk elyleacklm gvvpvsyfir
       61 nmeesyvnln hhglgprgtk aiaialvsnm avtkleledn cimeegvlsl vemlqenyyl
      121 qemnisnnhl glegariisd ffernsssiw slelsgndfk edsaallcqa lstnyqikkl
      181 dlshnqfsdv ggehlgqmla invgltsldl swnnfhtrga valcnglrgk ssdstaawst
      241 wisvamtsam kgppksakdw npmkasef
//
LOCUS       XP_047286972             255 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 74A isoform X7 [Homo
            sapiens].
ACCESSION   XP_047286972
VERSION     XP_047286972.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431016.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..255
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..255
                     /product="leucine-rich repeat-containing protein 74A
                     isoform X7"
                     /calculated_mol_wt=28034
     Region          <36..>210
                     /region_name="RNA1"
                     /note="Ran GTPase-activating protein (RanGAP) involved in
                     mRNA processing and transport [Translation, ribosomal
                     structure and biogenesis]; COG5238"
                     /db_xref="CDD:444072"
     Region          53..78
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          80..106
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          107..135
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          136..163
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          164..187
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          192..212
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     CDS             1..255
                     /gene="LRRC74A"
                     /gene_synonym="C14orf166B; LRRC74"
                     /coded_by="XM_047431016.1:40..807"
                     /db_xref="GeneID:145497"
                     /db_xref="HGNC:HGNC:23346"
ORIGIN      
        1 mfprgasyai faivlgddek ffttgqkely leacklmgvv pvsyfirnme esyvnlnhhg
       61 lgprgtkaia ialvsnmavt kleledncim eegvlslvem lqenyylqem nisnnhlgle
      121 gariisdffe rnsssiwsle lsgndfkeds aallcqalst nyqikkldls hnqfsdvgge
      181 hlgqmlainv gltsldlswn nfhtrgaval cnglrgkssd staawstwis vamtsamkgp
      241 pksakdwnpm kasef
//
LOCUS       XP_011534794            1124 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 128 kDa isoform X1 [Homo sapiens].
ACCESSION   XP_011534794
VERSION     XP_011534794.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536492.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1124
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1124
                     /product="centrosomal protein of 128 kDa isoform X1"
                     /calculated_mol_wt=131325
     Region          160..>827
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          753..>952
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..1124
                     /gene="CEP128"
                     /gene_synonym="C14orf145; C14orf61; LEDP/132"
                     /coded_by="XM_011536492.3:195..3569"
                     /db_xref="GeneID:145508"
                     /db_xref="HGNC:HGNC:20359"
                     /db_xref="MIM:620667"
ORIGIN      
        1 maesssesdh frcrdrlspw aarsthrgtr slptvevtek vntitstlqd tsrnlrqvdq
       61 mlgryreysn gqagaiehlk esleqsidql rsqrllrnsg grsisvtsls asdldggtgs
      121 elhhfpptsp lkdygdpqgi krmrsrtgvr fvqetddmtq lhgfhqslrd lsseqirlgd
      181 dfnrelsrrs rsdaetkral eelteklnea qkqevvsdrv errlqelere mrterelver
      241 rqdqlglmsl qlqealkkqe akadehegai knklrqtete knqleqelel srrllnqseg
      301 sretllhqve elrtqltkae gdrkglqhqv sqiskqqsny qdeqgedwrf rrgverekqd
      361 lekqmsdlrv qlnfsamase leevkrcmer kdkekahlas qvenltrele ngekqqlqml
      421 drlkeiqnhf dtceaerkha dlqiseltrh aedatkqaer ylselqqsea lkeeaekrre
      481 dlklkaqesi rqwklkhkkl eralekqset vdeltgknnq ilkekdelkt qlyaalqqie
      541 nlrkelndvl tkralqeeel hskeeklrdi kshqadlele vknsldtihr leselkkqsk
      601 iqsqmkveka hleeeiaelk ksqaqdkakl lemqesikdl sairadlank laeeerakka
      661 vlkdlsdlta qaksrdeeta tiitqlkler dvhqrelkdl tsslqsvktk heqniqelmk
      721 hfkkekseae nhirtlkaes leeknmakih rgqleklksq cdrlteeltq nenenkklkl
      781 kyqclkdqle erekhisiee ehlrrmeear lqlkdqllcl eteqesilgv igkeidaack
      841 tfskdsvekl kvfssgpdih ydphrwlaes ktklqwlcee lkerenrekn lrhqlmlcrq
      901 qlrnltenke selqclfqqi erqeqlldei hrekrdllee tqrkdeemgs lqpkllfklp
      961 pwedasqtav rnqseaqfee kadrvialet stqvaldhle svpeklslle dfkdfrdscs
     1021 ssertdgrys kyrvrrnslq hhqddtkyrt ksfkgdrtfl egshtrgldh ssswqdhsrf
     1081 lssprfsyvn sftkrtvapd sasnkedatm ngtssqpkke eygs
//
LOCUS       XP_011534793            1124 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 128 kDa isoform X1 [Homo sapiens].
ACCESSION   XP_011534793
VERSION     XP_011534793.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536491.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1124
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1124
                     /product="centrosomal protein of 128 kDa isoform X1"
                     /calculated_mol_wt=131325
     Region          160..>827
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          753..>952
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..1124
                     /gene="CEP128"
                     /gene_synonym="C14orf145; C14orf61; LEDP/132"
                     /coded_by="XM_011536491.3:330..3704"
                     /db_xref="GeneID:145508"
                     /db_xref="HGNC:HGNC:20359"
                     /db_xref="MIM:620667"
ORIGIN      
        1 maesssesdh frcrdrlspw aarsthrgtr slptvevtek vntitstlqd tsrnlrqvdq
       61 mlgryreysn gqagaiehlk esleqsidql rsqrllrnsg grsisvtsls asdldggtgs
      121 elhhfpptsp lkdygdpqgi krmrsrtgvr fvqetddmtq lhgfhqslrd lsseqirlgd
      181 dfnrelsrrs rsdaetkral eelteklnea qkqevvsdrv errlqelere mrterelver
      241 rqdqlglmsl qlqealkkqe akadehegai knklrqtete knqleqelel srrllnqseg
      301 sretllhqve elrtqltkae gdrkglqhqv sqiskqqsny qdeqgedwrf rrgverekqd
      361 lekqmsdlrv qlnfsamase leevkrcmer kdkekahlas qvenltrele ngekqqlqml
      421 drlkeiqnhf dtceaerkha dlqiseltrh aedatkqaer ylselqqsea lkeeaekrre
      481 dlklkaqesi rqwklkhkkl eralekqset vdeltgknnq ilkekdelkt qlyaalqqie
      541 nlrkelndvl tkralqeeel hskeeklrdi kshqadlele vknsldtihr leselkkqsk
      601 iqsqmkveka hleeeiaelk ksqaqdkakl lemqesikdl sairadlank laeeerakka
      661 vlkdlsdlta qaksrdeeta tiitqlkler dvhqrelkdl tsslqsvktk heqniqelmk
      721 hfkkekseae nhirtlkaes leeknmakih rgqleklksq cdrlteeltq nenenkklkl
      781 kyqclkdqle erekhisiee ehlrrmeear lqlkdqllcl eteqesilgv igkeidaack
      841 tfskdsvekl kvfssgpdih ydphrwlaes ktklqwlcee lkerenrekn lrhqlmlcrq
      901 qlrnltenke selqclfqqi erqeqlldei hrekrdllee tqrkdeemgs lqpkllfklp
      961 pwedasqtav rnqseaqfee kadrvialet stqvaldhle svpeklslle dfkdfrdscs
     1021 ssertdgrys kyrvrrnslq hhqddtkyrt ksfkgdrtfl egshtrgldh ssswqdhsrf
     1081 lssprfsyvn sftkrtvapd sasnkedatm ngtssqpkke eygs
//
LOCUS       XP_047286974            1094 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 128 kDa isoform X2 [Homo sapiens].
ACCESSION   XP_047286974
VERSION     XP_047286974.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431018.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1094
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1094
                     /product="centrosomal protein of 128 kDa isoform X2"
                     /calculated_mol_wt=127884
     Region          200..959
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1094
                     /gene="CEP128"
                     /gene_synonym="C14orf145; C14orf61; LEDP/132"
                     /coded_by="XM_047431018.1:448..3732"
                     /db_xref="GeneID:145508"
                     /db_xref="HGNC:HGNC:20359"
                     /db_xref="MIM:620667"
ORIGIN      
        1 maesssesdh frcrdrlspw aarsthrgtr slptvevtek vntitstlqd tsrnlrqvdq
       61 mlgryreysn gqagaiehlk esleqsidql rsqrllrnsg grsisvtsls asdldggtgs
      121 elhhfpptsp lkdygdpqgi krmrsrtgvr fvqetddmtq lhgfhqslrd lsseqirlgd
      181 dfnrelsrrs rsdaetkral eelteklnea qkqevvsdrv errlqelere mrterelver
      241 rqdqlglmsl qlqealkkqe akadehegai knklrqtete knqleqelel srrllnqseg
      301 sretllhqve elrtqltkae gdrkglqhqv sqiskqqsny qdeqgedwrf rrgverekqd
      361 lekqmsdlrv qlnfsamase leevkrcmer kdkekahlas qvenltrele ngekqqlqml
      421 drlkeiqnhf dtceaerkha dlqiseltrh aedatkqaer ylselqqsea lkeeaekrre
      481 dlklkaqesi rqwklkhkkl eralekqset vdeltgknnq ilkekdelkt qlyaalqqie
      541 nlrkelndvl tkralqeeel hskeeklrdi kshqadlele vknsldtihr leselkkqsk
      601 iqsqmkveka hleeeiaelk ksqaqdkakl lemqesikdl sairadlank laeeerakka
      661 vlkdlsdlta qaksrdeeta tiitqlkler dvhqrelkdl tsslqsvktk heqniqelmk
      721 hfkkekseae nhirtlkaes leeknmakih rgqleklksq cdrlteeltq nenenkklkl
      781 kyqclkdqle erekhisiee ehlrrmeear lqlkdqllcl eteqesilgv igkeidaack
      841 tfskdsvekl kvfssgpdih ydphrwlaes ktklqwlcee lkerenrekn lrhqlmlcrq
      901 qlrnltenke selqclfqqi erqeqlldei hrekrdllee tqrkdeemgs lqdrvialet
      961 stqvaldhle svpeklslle dfkdfrdscs ssertdgrys kyrvrrnslq hhqddtkyrt
     1021 ksfkgdrtfl egshtrgldh ssswqdhsrf lssprfsyvn sftkrtvapd sasnkedatm
     1081 ngtssqpkke eygs
//
LOCUS       XP_047286975            1094 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 128 kDa isoform X2 [Homo sapiens].
ACCESSION   XP_047286975
VERSION     XP_047286975.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431019.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1094
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1094
                     /product="centrosomal protein of 128 kDa isoform X2"
                     /calculated_mol_wt=127884
     Region          200..959
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1094
                     /gene="CEP128"
                     /gene_synonym="C14orf145; C14orf61; LEDP/132"
                     /coded_by="XM_047431019.1:351..3635"
                     /db_xref="GeneID:145508"
                     /db_xref="HGNC:HGNC:20359"
                     /db_xref="MIM:620667"
ORIGIN      
        1 maesssesdh frcrdrlspw aarsthrgtr slptvevtek vntitstlqd tsrnlrqvdq
       61 mlgryreysn gqagaiehlk esleqsidql rsqrllrnsg grsisvtsls asdldggtgs
      121 elhhfpptsp lkdygdpqgi krmrsrtgvr fvqetddmtq lhgfhqslrd lsseqirlgd
      181 dfnrelsrrs rsdaetkral eelteklnea qkqevvsdrv errlqelere mrterelver
      241 rqdqlglmsl qlqealkkqe akadehegai knklrqtete knqleqelel srrllnqseg
      301 sretllhqve elrtqltkae gdrkglqhqv sqiskqqsny qdeqgedwrf rrgverekqd
      361 lekqmsdlrv qlnfsamase leevkrcmer kdkekahlas qvenltrele ngekqqlqml
      421 drlkeiqnhf dtceaerkha dlqiseltrh aedatkqaer ylselqqsea lkeeaekrre
      481 dlklkaqesi rqwklkhkkl eralekqset vdeltgknnq ilkekdelkt qlyaalqqie
      541 nlrkelndvl tkralqeeel hskeeklrdi kshqadlele vknsldtihr leselkkqsk
      601 iqsqmkveka hleeeiaelk ksqaqdkakl lemqesikdl sairadlank laeeerakka
      661 vlkdlsdlta qaksrdeeta tiitqlkler dvhqrelkdl tsslqsvktk heqniqelmk
      721 hfkkekseae nhirtlkaes leeknmakih rgqleklksq cdrlteeltq nenenkklkl
      781 kyqclkdqle erekhisiee ehlrrmeear lqlkdqllcl eteqesilgv igkeidaack
      841 tfskdsvekl kvfssgpdih ydphrwlaes ktklqwlcee lkerenrekn lrhqlmlcrq
      901 qlrnltenke selqclfqqi erqeqlldei hrekrdllee tqrkdeemgs lqdrvialet
      961 stqvaldhle svpeklslle dfkdfrdscs ssertdgrys kyrvrrnslq hhqddtkyrt
     1021 ksfkgdrtfl egshtrgldh ssswqdhsrf lssprfsyvn sftkrtvapd sasnkedatm
     1081 ngtssqpkke eygs
//
LOCUS       XP_047286976            1094 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 128 kDa isoform X2 [Homo sapiens].
ACCESSION   XP_047286976
VERSION     XP_047286976.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431020.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1094
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1094
                     /product="centrosomal protein of 128 kDa isoform X2"
                     /calculated_mol_wt=127884
     Region          200..959
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1094
                     /gene="CEP128"
                     /gene_synonym="C14orf145; C14orf61; LEDP/132"
                     /coded_by="XM_047431020.1:233..3517"
                     /db_xref="GeneID:145508"
                     /db_xref="HGNC:HGNC:20359"
                     /db_xref="MIM:620667"
ORIGIN      
        1 maesssesdh frcrdrlspw aarsthrgtr slptvevtek vntitstlqd tsrnlrqvdq
       61 mlgryreysn gqagaiehlk esleqsidql rsqrllrnsg grsisvtsls asdldggtgs
      121 elhhfpptsp lkdygdpqgi krmrsrtgvr fvqetddmtq lhgfhqslrd lsseqirlgd
      181 dfnrelsrrs rsdaetkral eelteklnea qkqevvsdrv errlqelere mrterelver
      241 rqdqlglmsl qlqealkkqe akadehegai knklrqtete knqleqelel srrllnqseg
      301 sretllhqve elrtqltkae gdrkglqhqv sqiskqqsny qdeqgedwrf rrgverekqd
      361 lekqmsdlrv qlnfsamase leevkrcmer kdkekahlas qvenltrele ngekqqlqml
      421 drlkeiqnhf dtceaerkha dlqiseltrh aedatkqaer ylselqqsea lkeeaekrre
      481 dlklkaqesi rqwklkhkkl eralekqset vdeltgknnq ilkekdelkt qlyaalqqie
      541 nlrkelndvl tkralqeeel hskeeklrdi kshqadlele vknsldtihr leselkkqsk
      601 iqsqmkveka hleeeiaelk ksqaqdkakl lemqesikdl sairadlank laeeerakka
      661 vlkdlsdlta qaksrdeeta tiitqlkler dvhqrelkdl tsslqsvktk heqniqelmk
      721 hfkkekseae nhirtlkaes leeknmakih rgqleklksq cdrlteeltq nenenkklkl
      781 kyqclkdqle erekhisiee ehlrrmeear lqlkdqllcl eteqesilgv igkeidaack
      841 tfskdsvekl kvfssgpdih ydphrwlaes ktklqwlcee lkerenrekn lrhqlmlcrq
      901 qlrnltenke selqclfqqi erqeqlldei hrekrdllee tqrkdeemgs lqdrvialet
      961 stqvaldhle svpeklslle dfkdfrdscs ssertdgrys kyrvrrnslq hhqddtkyrt
     1021 ksfkgdrtfl egshtrgldh ssswqdhsrf lssprfsyvn sftkrtvapd sasnkedatm
     1081 ngtssqpkke eygs
//
LOCUS       XP_047286977            1094 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 128 kDa isoform X2 [Homo sapiens].
ACCESSION   XP_047286977
VERSION     XP_047286977.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431021.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1094
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1094
                     /product="centrosomal protein of 128 kDa isoform X2"
                     /calculated_mol_wt=127884
     Region          200..959
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1094
                     /gene="CEP128"
                     /gene_synonym="C14orf145; C14orf61; LEDP/132"
                     /coded_by="XM_047431021.1:243..3527"
                     /db_xref="GeneID:145508"
                     /db_xref="HGNC:HGNC:20359"
                     /db_xref="MIM:620667"
ORIGIN      
        1 maesssesdh frcrdrlspw aarsthrgtr slptvevtek vntitstlqd tsrnlrqvdq
       61 mlgryreysn gqagaiehlk esleqsidql rsqrllrnsg grsisvtsls asdldggtgs
      121 elhhfpptsp lkdygdpqgi krmrsrtgvr fvqetddmtq lhgfhqslrd lsseqirlgd
      181 dfnrelsrrs rsdaetkral eelteklnea qkqevvsdrv errlqelere mrterelver
      241 rqdqlglmsl qlqealkkqe akadehegai knklrqtete knqleqelel srrllnqseg
      301 sretllhqve elrtqltkae gdrkglqhqv sqiskqqsny qdeqgedwrf rrgverekqd
      361 lekqmsdlrv qlnfsamase leevkrcmer kdkekahlas qvenltrele ngekqqlqml
      421 drlkeiqnhf dtceaerkha dlqiseltrh aedatkqaer ylselqqsea lkeeaekrre
      481 dlklkaqesi rqwklkhkkl eralekqset vdeltgknnq ilkekdelkt qlyaalqqie
      541 nlrkelndvl tkralqeeel hskeeklrdi kshqadlele vknsldtihr leselkkqsk
      601 iqsqmkveka hleeeiaelk ksqaqdkakl lemqesikdl sairadlank laeeerakka
      661 vlkdlsdlta qaksrdeeta tiitqlkler dvhqrelkdl tsslqsvktk heqniqelmk
      721 hfkkekseae nhirtlkaes leeknmakih rgqleklksq cdrlteeltq nenenkklkl
      781 kyqclkdqle erekhisiee ehlrrmeear lqlkdqllcl eteqesilgv igkeidaack
      841 tfskdsvekl kvfssgpdih ydphrwlaes ktklqwlcee lkerenrekn lrhqlmlcrq
      901 qlrnltenke selqclfqqi erqeqlldei hrekrdllee tqrkdeemgs lqdrvialet
      961 stqvaldhle svpeklslle dfkdfrdscs ssertdgrys kyrvrrnslq hhqddtkyrt
     1021 ksfkgdrtfl egshtrgldh ssswqdhsrf lssprfsyvn sftkrtvapd sasnkedatm
     1081 ngtssqpkke eygs
//
LOCUS       XP_047286978            1094 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 128 kDa isoform X2 [Homo sapiens].
ACCESSION   XP_047286978
VERSION     XP_047286978.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431022.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1094
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1094
                     /product="centrosomal protein of 128 kDa isoform X2"
                     /calculated_mol_wt=127884
     Region          200..959
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1094
                     /gene="CEP128"
                     /gene_synonym="C14orf145; C14orf61; LEDP/132"
                     /coded_by="XM_047431022.1:195..3479"
                     /db_xref="GeneID:145508"
                     /db_xref="HGNC:HGNC:20359"
                     /db_xref="MIM:620667"
ORIGIN      
        1 maesssesdh frcrdrlspw aarsthrgtr slptvevtek vntitstlqd tsrnlrqvdq
       61 mlgryreysn gqagaiehlk esleqsidql rsqrllrnsg grsisvtsls asdldggtgs
      121 elhhfpptsp lkdygdpqgi krmrsrtgvr fvqetddmtq lhgfhqslrd lsseqirlgd
      181 dfnrelsrrs rsdaetkral eelteklnea qkqevvsdrv errlqelere mrterelver
      241 rqdqlglmsl qlqealkkqe akadehegai knklrqtete knqleqelel srrllnqseg
      301 sretllhqve elrtqltkae gdrkglqhqv sqiskqqsny qdeqgedwrf rrgverekqd
      361 lekqmsdlrv qlnfsamase leevkrcmer kdkekahlas qvenltrele ngekqqlqml
      421 drlkeiqnhf dtceaerkha dlqiseltrh aedatkqaer ylselqqsea lkeeaekrre
      481 dlklkaqesi rqwklkhkkl eralekqset vdeltgknnq ilkekdelkt qlyaalqqie
      541 nlrkelndvl tkralqeeel hskeeklrdi kshqadlele vknsldtihr leselkkqsk
      601 iqsqmkveka hleeeiaelk ksqaqdkakl lemqesikdl sairadlank laeeerakka
      661 vlkdlsdlta qaksrdeeta tiitqlkler dvhqrelkdl tsslqsvktk heqniqelmk
      721 hfkkekseae nhirtlkaes leeknmakih rgqleklksq cdrlteeltq nenenkklkl
      781 kyqclkdqle erekhisiee ehlrrmeear lqlkdqllcl eteqesilgv igkeidaack
      841 tfskdsvekl kvfssgpdih ydphrwlaes ktklqwlcee lkerenrekn lrhqlmlcrq
      901 qlrnltenke selqclfqqi erqeqlldei hrekrdllee tqrkdeemgs lqdrvialet
      961 stqvaldhle svpeklslle dfkdfrdscs ssertdgrys kyrvrrnslq hhqddtkyrt
     1021 ksfkgdrtfl egshtrgldh ssswqdhsrf lssprfsyvn sftkrtvapd sasnkedatm
     1081 ngtssqpkke eygs
//
LOCUS       XP_011534795            1090 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 128 kDa isoform X3 [Homo sapiens].
ACCESSION   XP_011534795
VERSION     XP_011534795.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536493.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1090
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1090
                     /product="centrosomal protein of 128 kDa isoform X3"
                     /calculated_mol_wt=127693
     Region          160..>827
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          753..>952
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..1090
                     /gene="CEP128"
                     /gene_synonym="C14orf145; C14orf61; LEDP/132"
                     /coded_by="XM_011536493.3:330..3602"
                     /db_xref="GeneID:145508"
                     /db_xref="HGNC:HGNC:20359"
                     /db_xref="MIM:620667"
ORIGIN      
        1 maesssesdh frcrdrlspw aarsthrgtr slptvevtek vntitstlqd tsrnlrqvdq
       61 mlgryreysn gqagaiehlk esleqsidql rsqrllrnsg grsisvtsls asdldggtgs
      121 elhhfpptsp lkdygdpqgi krmrsrtgvr fvqetddmtq lhgfhqslrd lsseqirlgd
      181 dfnrelsrrs rsdaetkral eelteklnea qkqevvsdrv errlqelere mrterelver
      241 rqdqlglmsl qlqealkkqe akadehegai knklrqtete knqleqelel srrllnqseg
      301 sretllhqve elrtqltkae gdrkglqhqv sqiskqqsny qdeqgedwrf rrgverekqd
      361 lekqmsdlrv qlnfsamase leevkrcmer kdkekahlas qvenltrele ngekqqlqml
      421 drlkeiqnhf dtceaerkha dlqiseltrh aedatkqaer ylselqqsea lkeeaekrre
      481 dlklkaqesi rqwklkhkkl eralekqset vdeltgknnq ilkekdelkt qlyaalqqie
      541 nlrkelndvl tkralqeeel hskeeklrdi kshqadlele vknsldtihr leselkkqsk
      601 iqsqmkveka hleeeiaelk ksqaqdkakl lemqesikdl sairadlank laeeerakka
      661 vlkdlsdlta qaksrdeeta tiitqlkler dvhqrelkdl tsslqsvktk heqniqelmk
      721 hfkkekseae nhirtlkaes leeknmakih rgqleklksq cdrlteeltq nenenkklkl
      781 kyqclkdqle erekhisiee ehlrrmeear lqlkdqllcl eteqesilgv igkeidaack
      841 tfskdsvekl kvfssgpdih ydphrwlaes ktklqwlcee lkerenrekn lrhqlmlcrq
      901 qlrnltenke selqclfqqi erqeqlldei hrekrdllee tqrkdeemgs lqpkllfklp
      961 pwedasqtav rnqseaqfee kadrvialet stqvaldhle svpeklslle dfkdfrdscs
     1021 ssertdgrys kyrvrrnslq hhqddtkyrt ksfkgdrtfl egshtrgldh ssswqdhsrf
     1081 lssprfsyvn
//
LOCUS       XP_047286979            1060 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 128 kDa isoform X4 [Homo sapiens].
ACCESSION   XP_047286979
VERSION     XP_047286979.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431023.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1060
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1060
                     /product="centrosomal protein of 128 kDa isoform X4"
                     /calculated_mol_wt=124253
     Region          200..959
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1060
                     /gene="CEP128"
                     /gene_synonym="C14orf145; C14orf61; LEDP/132"
                     /coded_by="XM_047431023.1:330..3512"
                     /db_xref="GeneID:145508"
                     /db_xref="HGNC:HGNC:20359"
                     /db_xref="MIM:620667"
ORIGIN      
        1 maesssesdh frcrdrlspw aarsthrgtr slptvevtek vntitstlqd tsrnlrqvdq
       61 mlgryreysn gqagaiehlk esleqsidql rsqrllrnsg grsisvtsls asdldggtgs
      121 elhhfpptsp lkdygdpqgi krmrsrtgvr fvqetddmtq lhgfhqslrd lsseqirlgd
      181 dfnrelsrrs rsdaetkral eelteklnea qkqevvsdrv errlqelere mrterelver
      241 rqdqlglmsl qlqealkkqe akadehegai knklrqtete knqleqelel srrllnqseg
      301 sretllhqve elrtqltkae gdrkglqhqv sqiskqqsny qdeqgedwrf rrgverekqd
      361 lekqmsdlrv qlnfsamase leevkrcmer kdkekahlas qvenltrele ngekqqlqml
      421 drlkeiqnhf dtceaerkha dlqiseltrh aedatkqaer ylselqqsea lkeeaekrre
      481 dlklkaqesi rqwklkhkkl eralekqset vdeltgknnq ilkekdelkt qlyaalqqie
      541 nlrkelndvl tkralqeeel hskeeklrdi kshqadlele vknsldtihr leselkkqsk
      601 iqsqmkveka hleeeiaelk ksqaqdkakl lemqesikdl sairadlank laeeerakka
      661 vlkdlsdlta qaksrdeeta tiitqlkler dvhqrelkdl tsslqsvktk heqniqelmk
      721 hfkkekseae nhirtlkaes leeknmakih rgqleklksq cdrlteeltq nenenkklkl
      781 kyqclkdqle erekhisiee ehlrrmeear lqlkdqllcl eteqesilgv igkeidaack
      841 tfskdsvekl kvfssgpdih ydphrwlaes ktklqwlcee lkerenrekn lrhqlmlcrq
      901 qlrnltenke selqclfqqi erqeqlldei hrekrdllee tqrkdeemgs lqdrvialet
      961 stqvaldhle svpeklslle dfkdfrdscs ssertdgrys kyrvrrnslq hhqddtkyrt
     1021 ksfkgdrtfl egshtrgldh ssswqdhsrf lssprfsyvn
//
LOCUS       XP_047286981            1054 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 128 kDa isoform X5 [Homo sapiens].
ACCESSION   XP_047286981
VERSION     XP_047286981.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431025.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1054
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1054
                     /product="centrosomal protein of 128 kDa isoform X5"
                     /calculated_mol_wt=123259
     Region          160..>827
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          753..>952
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..1054
                     /gene="CEP128"
                     /gene_synonym="C14orf145; C14orf61; LEDP/132"
                     /coded_by="XM_047431025.1:330..3494"
                     /db_xref="GeneID:145508"
                     /db_xref="HGNC:HGNC:20359"
                     /db_xref="MIM:620667"
ORIGIN      
        1 maesssesdh frcrdrlspw aarsthrgtr slptvevtek vntitstlqd tsrnlrqvdq
       61 mlgryreysn gqagaiehlk esleqsidql rsqrllrnsg grsisvtsls asdldggtgs
      121 elhhfpptsp lkdygdpqgi krmrsrtgvr fvqetddmtq lhgfhqslrd lsseqirlgd
      181 dfnrelsrrs rsdaetkral eelteklnea qkqevvsdrv errlqelere mrterelver
      241 rqdqlglmsl qlqealkkqe akadehegai knklrqtete knqleqelel srrllnqseg
      301 sretllhqve elrtqltkae gdrkglqhqv sqiskqqsny qdeqgedwrf rrgverekqd
      361 lekqmsdlrv qlnfsamase leevkrcmer kdkekahlas qvenltrele ngekqqlqml
      421 drlkeiqnhf dtceaerkha dlqiseltrh aedatkqaer ylselqqsea lkeeaekrre
      481 dlklkaqesi rqwklkhkkl eralekqset vdeltgknnq ilkekdelkt qlyaalqqie
      541 nlrkelndvl tkralqeeel hskeeklrdi kshqadlele vknsldtihr leselkkqsk
      601 iqsqmkveka hleeeiaelk ksqaqdkakl lemqesikdl sairadlank laeeerakka
      661 vlkdlsdlta qaksrdeeta tiitqlkler dvhqrelkdl tsslqsvktk heqniqelmk
      721 hfkkekseae nhirtlkaes leeknmakih rgqleklksq cdrlteeltq nenenkklkl
      781 kyqclkdqle erekhisiee ehlrrmeear lqlkdqllcl eteqesilgv igkeidaack
      841 tfskdsvekl kvfssgpdih ydphrwlaes ktklqwlcee lkerenrekn lrhqlmlcrq
      901 qlrnltenke selqclfqqi erqeqlldei hrekrdllee tqrkdeemgs lqpkllfklp
      961 pwedasqtav rnqseaqfee kadrvialet vswgifflll selllspdvd ftahqrkqfq
     1021 ksfrklhlrc qrgkqaklyl keypsglgps gvca
//
LOCUS       XP_047286982            1024 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 128 kDa isoform X6 [Homo sapiens].
ACCESSION   XP_047286982
VERSION     XP_047286982.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431026.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1024
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1024
                     /product="centrosomal protein of 128 kDa isoform X6"
                     /calculated_mol_wt=119818
     Region          200..959
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1024
                     /gene="CEP128"
                     /gene_synonym="C14orf145; C14orf61; LEDP/132"
                     /coded_by="XM_047431026.1:330..3404"
                     /db_xref="GeneID:145508"
                     /db_xref="HGNC:HGNC:20359"
                     /db_xref="MIM:620667"
ORIGIN      
        1 maesssesdh frcrdrlspw aarsthrgtr slptvevtek vntitstlqd tsrnlrqvdq
       61 mlgryreysn gqagaiehlk esleqsidql rsqrllrnsg grsisvtsls asdldggtgs
      121 elhhfpptsp lkdygdpqgi krmrsrtgvr fvqetddmtq lhgfhqslrd lsseqirlgd
      181 dfnrelsrrs rsdaetkral eelteklnea qkqevvsdrv errlqelere mrterelver
      241 rqdqlglmsl qlqealkkqe akadehegai knklrqtete knqleqelel srrllnqseg
      301 sretllhqve elrtqltkae gdrkglqhqv sqiskqqsny qdeqgedwrf rrgverekqd
      361 lekqmsdlrv qlnfsamase leevkrcmer kdkekahlas qvenltrele ngekqqlqml
      421 drlkeiqnhf dtceaerkha dlqiseltrh aedatkqaer ylselqqsea lkeeaekrre
      481 dlklkaqesi rqwklkhkkl eralekqset vdeltgknnq ilkekdelkt qlyaalqqie
      541 nlrkelndvl tkralqeeel hskeeklrdi kshqadlele vknsldtihr leselkkqsk
      601 iqsqmkveka hleeeiaelk ksqaqdkakl lemqesikdl sairadlank laeeerakka
      661 vlkdlsdlta qaksrdeeta tiitqlkler dvhqrelkdl tsslqsvktk heqniqelmk
      721 hfkkekseae nhirtlkaes leeknmakih rgqleklksq cdrlteeltq nenenkklkl
      781 kyqclkdqle erekhisiee ehlrrmeear lqlkdqllcl eteqesilgv igkeidaack
      841 tfskdsvekl kvfssgpdih ydphrwlaes ktklqwlcee lkerenrekn lrhqlmlcrq
      901 qlrnltenke selqclfqqi erqeqlldei hrekrdllee tqrkdeemgs lqdrvialet
      961 vswgifflll selllspdvd ftahqrkqfq ksfrklhlrc qrgkqaklyl keypsglgps
     1021 gvca
//
LOCUS       XP_047286983             982 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 128 kDa isoform X7 [Homo sapiens].
ACCESSION   XP_047286983
VERSION     XP_047286983.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431027.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..982
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..982
                     /product="centrosomal protein of 128 kDa isoform X7"
                     /calculated_mol_wt=115546
     Region          18..>685
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          611..>810
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..982
                     /gene="CEP128"
                     /gene_synonym="C14orf145; C14orf61; LEDP/132"
                     /coded_by="XM_047431027.1:346..3294"
                     /db_xref="GeneID:145508"
                     /db_xref="HGNC:HGNC:20359"
                     /db_xref="MIM:620667"
ORIGIN      
        1 mrsrtgvrfv qetddmtqlh gfhqslrdls seqirlgddf nrelsrrsrs daetkralee
       61 lteklneaqk qevvsdrver rlqeleremr terelverrq dqlglmslql qealkkqeak
      121 adehegaikn klrqtetekn qleqelelsr rllnqsegsr etllhqveel rtqltkaegd
      181 rkglqhqvsq iskqqsnyqd eqgedwrfrr gverekqdle kqmsdlrvql nfsamasele
      241 evkrcmerkd kekahlasqv enltreleng ekqqlqmldr lkeiqnhfdt ceaerkhadl
      301 qiseltrhae datkqaeryl selqqsealk eeaekrredl klkaqesirq wklkhkkler
      361 alekqsetvd eltgknnqil kekdelktql yaalqqienl rkelndvltk ralqeeelhs
      421 keeklrdiks hqadlelevk nsldtihrle selkkqskiq sqmkvekahl eeeiaelkks
      481 qaqdkaklle mqesikdlsa iradlankla eeerakkavl kdlsdltaqa ksrdeetati
      541 itqlklerdv hqrelkdlts slqsvktkhe qniqelmkhf kkekseaenh irtlkaesle
      601 eknmakihrg qleklksqcd rlteeltqne nenkklklky qclkdqleer ekhisieeeh
      661 lrrmeearlq lkdqllclet eqesilgvig keidaacktf skdsveklkv fssgpdihyd
      721 phrwlaeskt klqwlceelk erenreknlr hqlmlcrqql rnltenkese lqclfqqier
      781 qeqlldeihr ekrdlleetq rkdeemgslq pkllfklppw edasqtavrn qseaqfeeka
      841 drvialetst qvaldhlesv peklslledf kdfrdscsss ertdgrysky rvrrnslqhh
      901 qddtkyrtks fkgdrtfleg shtrgldhss swqdhsrfls sprfsyvnsf tkrtvapdsa
      961 snkedatmng tssqpkkeey gs
//
LOCUS       XP_011534797             944 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 128 kDa isoform X8 [Homo sapiens].
ACCESSION   XP_011534797
VERSION     XP_011534797.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536495.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..944
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..944
                     /product="centrosomal protein of 128 kDa isoform X8"
                     /calculated_mol_wt=110609
     Region          160..>827
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          753..>935
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..944
                     /gene="CEP128"
                     /gene_synonym="C14orf145; C14orf61; LEDP/132"
                     /coded_by="XM_011536495.3:330..3164"
                     /db_xref="GeneID:145508"
                     /db_xref="HGNC:HGNC:20359"
                     /db_xref="MIM:620667"
ORIGIN      
        1 maesssesdh frcrdrlspw aarsthrgtr slptvevtek vntitstlqd tsrnlrqvdq
       61 mlgryreysn gqagaiehlk esleqsidql rsqrllrnsg grsisvtsls asdldggtgs
      121 elhhfpptsp lkdygdpqgi krmrsrtgvr fvqetddmtq lhgfhqslrd lsseqirlgd
      181 dfnrelsrrs rsdaetkral eelteklnea qkqevvsdrv errlqelere mrterelver
      241 rqdqlglmsl qlqealkkqe akadehegai knklrqtete knqleqelel srrllnqseg
      301 sretllhqve elrtqltkae gdrkglqhqv sqiskqqsny qdeqgedwrf rrgverekqd
      361 lekqmsdlrv qlnfsamase leevkrcmer kdkekahlas qvenltrele ngekqqlqml
      421 drlkeiqnhf dtceaerkha dlqiseltrh aedatkqaer ylselqqsea lkeeaekrre
      481 dlklkaqesi rqwklkhkkl eralekqset vdeltgknnq ilkekdelkt qlyaalqqie
      541 nlrkelndvl tkralqeeel hskeeklrdi kshqadlele vknsldtihr leselkkqsk
      601 iqsqmkveka hleeeiaelk ksqaqdkakl lemqesikdl sairadlank laeeerakka
      661 vlkdlsdlta qaksrdeeta tiitqlkler dvhqrelkdl tsslqsvktk heqniqelmk
      721 hfkkekseae nhirtlkaes leeknmakih rgqleklksq cdrlteeltq nenenkklkl
      781 kyqclkdqle erekhisiee ehlrrmeear lqlkdqllcl eteqesilgv igkeidaack
      841 tfskdsvekl kvfssgpdih ydphrwlaes ktklqwlcee lkerenrekn lrhqlmlcrq
      901 qlrnltenke selqclfqqi erqeqlldei hrekrgifpi ntrl
//
LOCUS       XP_016876532             722 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 128 kDa isoform X9 [Homo sapiens].
ACCESSION   XP_016876532
VERSION     XP_016876532.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021043.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..722
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..722
                     /product="centrosomal protein of 128 kDa isoform X9"
                     /calculated_mol_wt=84724
     Region          <33..>565
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     CDS             1..722
                     /gene="CEP128"
                     /gene_synonym="C14orf145; C14orf61; LEDP/132"
                     /coded_by="XM_017021043.2:52..2220"
                     /db_xref="GeneID:145508"
                     /db_xref="HGNC:HGNC:20359"
                     /db_xref="MIM:620667"
ORIGIN      
        1 mnltreleng ekqqlqmldr lkeiqnhfdt ceaerkhadl qiseltrhae datkqaeryl
       61 selqqsealk eeaekrredl klkaqesirq wklkhkkler alekqsetvd eltgknnqil
      121 kekdelktql yaalqqienl rkelndvltk ralqeeelhs keeklrdiks hqadlelevk
      181 nsldtihrle selkkqskiq sqmkvekahl eeeiaelkks qaqdkaklle mqesikdlsa
      241 iradlankla eeerakkavl kdlsdltaqa ksrdeetati itqlklerdv hqrelkdlts
      301 slqsvktkhe qniqelmkhf kkekseaenh irtlkaesle eknmakihrg qleklksqcd
      361 rlteeltqne nenkklklky qclkdqleer ekhisieeeh lrrmeearlq lkdqllclet
      421 eqesilgvig keidaacktf skdsveklkv fssgpdihyd phrwlaeskt klqwlceelk
      481 erenreknlr hqlmlcrqql rnltenkese lqclfqqier qeqlldeihr ekrdlleetq
      541 rkdeemgslq pkllfklppw edasqtavrn qseaqfeeka drvialetst qvaldhlesv
      601 peklslledf kdfrdscsss ertdgrysky rvrrnslqhh qddtkyrtks fkgdrtfleg
      661 shtrgldhss swqdhsrfls sprfsyvnsf tkrtvapdsa snkedatmng tssqpkkeey
      721 gs
//
LOCUS       XP_047286985             719 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat and fibronectin type-III domain-containing
            protein 5 isoform X1 [Homo sapiens].
ACCESSION   XP_047286985
VERSION     XP_047286985.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431029.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..719
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..719
                     /product="leucine-rich repeat and fibronectin type-III
                     domain-containing protein 5 isoform X1"
                     /calculated_mol_wt=79314
     Region          53..76
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          <69..>211
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          77..100
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          101..124
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          125..148
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          149..172
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          173..196
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          197..215
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          240..>272
                     /region_name="LRRCT"
                     /note="Leucine rich repeat C-terminal domain; smart00082"
                     /db_xref="CDD:214507"
     Region          287..374
                     /region_name="IgI_SALM5_like"
                     /note="Immunoglobulin domain of human Synaptic
                     Adhesion-Like Molecule 5 (SALM5) and similar proteins;
                     member of the I-set of IgSF domains; cd05764"
                     /db_xref="CDD:409421"
     Region          287..290
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409421"
     Region          294..297
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409421"
     Region          303..311
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409421"
     Site            order(309,311,319,326,361..363,365)
                     /site_type="other"
                     /note="PTPdelta binding site [polypeptide binding]"
                     /db_xref="CDD:409421"
     Region          317..322
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409421"
     Region          325..327
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409421"
     Region          333..337
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409421"
     Region          340..344
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409421"
     Region          354..361
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409421"
     Region          364..374
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409421"
     Region          421..494
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cl21522"
                     /db_xref="CDD:473895"
     CDS             1..719
                     /gene="LRFN5"
                     /gene_synonym="C14orf146; FIGLER8; SALM5"
                     /coded_by="XM_047431029.1:17516..19675"
                     /db_xref="GeneID:145581"
                     /db_xref="HGNC:HGNC:20360"
                     /db_xref="MIM:612811"
ORIGIN      
        1 mekilfylfl igiavkaqic pkrcvcqils pnlatlcakk gllfvppnid rrtvelrlad
       61 nfvtnikrkd fanmtslvdl tlsrntisfi tphafadlrn lralhlnsnr ltkitndmfs
      121 glsnlhhlil nnnqltliss tafddvfale eldlsynnle tipwdavekm vslhtlsldh
      181 nmidnipkgt fshlhkmtrl dvtsnklqkl ppdplfqraq vlatsgiisp stfalsfggn
      241 plhcncellw lrrlsreddl etcasppllt gryfwsipee eflcepplit rhthemrvle
      301 gqratlrcka rgdpepaihw ispegklisn atrslvydng tldilittvk dtgaftcias
      361 npageatqiv dlhiiklphl lnstnhihep dpgssdists tksgsntsss ngdtklsqdk
      421 ivvaeatsst allkfnfqrn ipgirmfqiq yngtyddtlv yrmipptskt flvnnlaagt
      481 mydlcvlaiy ddgitsltat rvvgciqftt eqdyvrchfm qsqflggtmi iiiggiivas
      541 vlvfiiilmi rykvcnnngq hkvtkvsnvy sqtngaqiqg csvtlpqsvs kqavgheena
      601 qcckatsdnv iqssetcssq dsstttsalp pswtsstsvs qkqkrktgtk pstepqneav
      661 tnvesqntnr nnstalqlas rppdsvtegp tskrahikpn alltnvdqiv qetqrleli
//
LOCUS       XP_011534801             269 aa            linear   PRI 05-AUG-2025
DEFINITION  cathepsin G isoform X1 [Homo sapiens].
ACCESSION   XP_011534801
VERSION     XP_011534801.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536499.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..269
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..269
                     /product="cathepsin G isoform X1"
                     /calculated_mol_wt=30111
     Region          35..255
                     /region_name="Tryp_SPc"
                     /note="Trypsin-like serine protease; Many of these are
                     synthesized as inactive precursor zymogens that are
                     cleaved during limited proteolysis to generate their
                     active forms. Alignment contains also inactive enzymes
                     that have substitutions of the catalytic triad...;
                     cd00190"
                     /db_xref="CDD:238113"
     Site            35
                     /site_type="active"
                     /note="cleavage site [active]"
                     /db_xref="CDD:238113"
     Site            order(78,122,215)
                     /site_type="active"
                     /db_xref="CDD:238113"
     Site            order(209,230,232)
                     /site_type="other"
                     /note="substrate binding sites [chemical binding]"
                     /db_xref="CDD:238113"
     CDS             1..269
                     /gene="CTSG"
                     /gene_synonym="CATG; CG"
                     /coded_by="XM_011536499.2:28..837"
                     /db_xref="GeneID:1511"
                     /db_xref="HGNC:HGNC:2532"
                     /db_xref="MIM:116830"
ORIGIN      
        1 mqplllllaf llptgaeags asielsakcf lpgeiiggre srphsrpyma ylqiqspagq
       61 srcggflvre dfvltaahcw gsninvtlga hniqrrentq qhitarrair hpqynqrtiq
      121 ndimllqlsr rvrrnrnvnp valpraqegl rpgtlctvag wgrvsmrrgt dtlrevqlrv
      181 qrdrqclrif gsydprrqic vgdrrerkaa fkgdsggpll cnnvahgivs ygkssgvppe
      241 vftrvssflp wirttmrsfk lldqmetpl
//
LOCUS       XP_011534802             422 aa            linear   PRI 05-AUG-2025
DEFINITION  Golgi-associated RAB2 interactor protein 2 isoform X1 [Homo
            sapiens].
ACCESSION   XP_011534802
VERSION     XP_011534802.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536500.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..422
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..422
                     /product="Golgi-associated RAB2 interactor protein 2
                     isoform X1"
                     /calculated_mol_wt=46945
     Region          116..185
                     /region_name="DUF3699"
                     /note="Protein of unknown function (DUF3699); pfam12480"
                     /db_xref="CDD:463601"
     CDS             1..422
                     /gene="GARIN2"
                     /gene_synonym="C14orf54; FAM71D; GARI-L1; GARI-L2"
                     /coded_by="XM_011536500.2:244..1512"
                     /db_xref="GeneID:161142"
                     /db_xref="HGNC:HGNC:20101"
                     /db_xref="MIM:619898"
ORIGIN      
        1 mkkntskttm rinkqdalct phshdprdlq nmldggeyap fvsppmlesn fiqvnrrges
       61 iylhnranwv tvgicfssst hkipnvmlla hltpgaqkdt etlfksllts ppaeklvltr
      121 flplqfvtls vhdaenmslk vklvsgrayy lqlctsaykq dtlfsqwval isllnqekak
      181 vskvsevssl sgitnstdit gsmdvtdvtt ftailtpymy agtgpehvrd sidfpeftdi
      241 tditdvtdlp enevpevpdv rivtevievr eatevtdssd itncsgvtvv fenndlirak
      301 qeekeklkni lkpgclqdtk skselkessk hvtisnitlt fegkryfqtt ltpveseant
      361 skemkdktse ekmpdfqsta lkaeesrslr tesntsvlsp hikspsnflk lvphlsapfs
      421 re
//
LOCUS       XP_047286987             422 aa            linear   PRI 05-AUG-2025
DEFINITION  Golgi-associated RAB2 interactor protein 2 isoform X1 [Homo
            sapiens].
ACCESSION   XP_047286987
VERSION     XP_047286987.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431031.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..422
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..422
                     /product="Golgi-associated RAB2 interactor protein 2
                     isoform X1"
                     /calculated_mol_wt=46945
     Region          116..185
                     /region_name="DUF3699"
                     /note="Protein of unknown function (DUF3699); pfam12480"
                     /db_xref="CDD:463601"
     CDS             1..422
                     /gene="GARIN2"
                     /gene_synonym="C14orf54; FAM71D; GARI-L1; GARI-L2"
                     /coded_by="XM_047431031.1:190..1458"
                     /db_xref="GeneID:161142"
                     /db_xref="HGNC:HGNC:20101"
                     /db_xref="MIM:619898"
ORIGIN      
        1 mkkntskttm rinkqdalct phshdprdlq nmldggeyap fvsppmlesn fiqvnrrges
       61 iylhnranwv tvgicfssst hkipnvmlla hltpgaqkdt etlfksllts ppaeklvltr
      121 flplqfvtls vhdaenmslk vklvsgrayy lqlctsaykq dtlfsqwval isllnqekak
      181 vskvsevssl sgitnstdit gsmdvtdvtt ftailtpymy agtgpehvrd sidfpeftdi
      241 tditdvtdlp enevpevpdv rivtevievr eatevtdssd itncsgvtvv fenndlirak
      301 qeekeklkni lkpgclqdtk skselkessk hvtisnitlt fegkryfqtt ltpveseant
      361 skemkdktse ekmpdfqsta lkaeesrslr tesntsvlsp hikspsnflk lvphlsapfs
      421 re
//
LOCUS       XP_011534805             422 aa            linear   PRI 05-AUG-2025
DEFINITION  Golgi-associated RAB2 interactor protein 2 isoform X1 [Homo
            sapiens].
ACCESSION   XP_011534805
VERSION     XP_011534805.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536503.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..422
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..422
                     /product="Golgi-associated RAB2 interactor protein 2
                     isoform X1"
                     /calculated_mol_wt=46945
     Region          116..185
                     /region_name="DUF3699"
                     /note="Protein of unknown function (DUF3699); pfam12480"
                     /db_xref="CDD:463601"
     CDS             1..422
                     /gene="GARIN2"
                     /gene_synonym="C14orf54; FAM71D; GARI-L1; GARI-L2"
                     /coded_by="XM_011536503.3:157..1425"
                     /db_xref="GeneID:161142"
                     /db_xref="HGNC:HGNC:20101"
                     /db_xref="MIM:619898"
ORIGIN      
        1 mkkntskttm rinkqdalct phshdprdlq nmldggeyap fvsppmlesn fiqvnrrges
       61 iylhnranwv tvgicfssst hkipnvmlla hltpgaqkdt etlfksllts ppaeklvltr
      121 flplqfvtls vhdaenmslk vklvsgrayy lqlctsaykq dtlfsqwval isllnqekak
      181 vskvsevssl sgitnstdit gsmdvtdvtt ftailtpymy agtgpehvrd sidfpeftdi
      241 tditdvtdlp enevpevpdv rivtevievr eatevtdssd itncsgvtvv fenndlirak
      301 qeekeklkni lkpgclqdtk skselkessk hvtisnitlt fegkryfqtt ltpveseant
      361 skemkdktse ekmpdfqsta lkaeesrslr tesntsvlsp hikspsnflk lvphlsapfs
      421 re
//
LOCUS       XP_047286989             417 aa            linear   PRI 05-AUG-2025
DEFINITION  Golgi-associated RAB2 interactor protein 2 isoform X2 [Homo
            sapiens].
ACCESSION   XP_047286989
VERSION     XP_047286989.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431033.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..417
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..417
                     /product="Golgi-associated RAB2 interactor protein 2
                     isoform X2"
                     /calculated_mol_wt=46406
     Region          116..185
                     /region_name="DUF3699"
                     /note="Protein of unknown function (DUF3699); pfam12480"
                     /db_xref="CDD:463601"
     CDS             1..417
                     /gene="GARIN2"
                     /gene_synonym="C14orf54; FAM71D; GARI-L1; GARI-L2"
                     /coded_by="XM_047431033.1:244..1497"
                     /db_xref="GeneID:161142"
                     /db_xref="HGNC:HGNC:20101"
                     /db_xref="MIM:619898"
ORIGIN      
        1 mkkntskttm rinkqdalct phshdprdlq nmldggeyap fvsppmlesn fiqvnrrges
       61 iylhnranwv tvgicfssst hkipnvmlla hltpgaqkdt etlfksllts ppaeklvltr
      121 flplqfvtls vhdaenmslk vklvsgrayy lqlctsaykq dtlfsqwval isllnqekak
      181 vskvsevssl sgitnstdit gsmdvtdvtt ftailtpymy agtgpehvrd sidfpeftdi
      241 tditdvtdlp enevpevpdv rivtevievr eatevtdssd itncsgvtvv fenndlirak
      301 qeekeklkni lkpgclqdtk skselkessk hvtisnitlt fegkryfqtt ltpveseant
      361 skemkdktse ekmpdfqsta lkaeesrslr tesntsglys fsvfplisis fpiftll
//
LOCUS       XP_047286990             417 aa            linear   PRI 05-AUG-2025
DEFINITION  Golgi-associated RAB2 interactor protein 2 isoform X2 [Homo
            sapiens].
ACCESSION   XP_047286990
VERSION     XP_047286990.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431034.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..417
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..417
                     /product="Golgi-associated RAB2 interactor protein 2
                     isoform X2"
                     /calculated_mol_wt=46406
     Region          116..185
                     /region_name="DUF3699"
                     /note="Protein of unknown function (DUF3699); pfam12480"
                     /db_xref="CDD:463601"
     CDS             1..417
                     /gene="GARIN2"
                     /gene_synonym="C14orf54; FAM71D; GARI-L1; GARI-L2"
                     /coded_by="XM_047431034.1:157..1410"
                     /db_xref="GeneID:161142"
                     /db_xref="HGNC:HGNC:20101"
                     /db_xref="MIM:619898"
ORIGIN      
        1 mkkntskttm rinkqdalct phshdprdlq nmldggeyap fvsppmlesn fiqvnrrges
       61 iylhnranwv tvgicfssst hkipnvmlla hltpgaqkdt etlfksllts ppaeklvltr
      121 flplqfvtls vhdaenmslk vklvsgrayy lqlctsaykq dtlfsqwval isllnqekak
      181 vskvsevssl sgitnstdit gsmdvtdvtt ftailtpymy agtgpehvrd sidfpeftdi
      241 tditdvtdlp enevpevpdv rivtevievr eatevtdssd itncsgvtvv fenndlirak
      301 qeekeklkni lkpgclqdtk skselkessk hvtisnitlt fegkryfqtt ltpveseant
      361 skemkdktse ekmpdfqsta lkaeesrslr tesntsglys fsvfplisis fpiftll
//
LOCUS       XP_047286992             167 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 229B isoform X1 [Homo sapiens].
ACCESSION   XP_047286992
VERSION     XP_047286992.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431036.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..167
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..167
                     /product="transmembrane protein 229B isoform X1"
                     /calculated_mol_wt=19400
     Region          <50..>135
                     /region_name="ABC_trans_CmpB"
                     /note="Putative ABC-transporter type IV; cl46401"
                     /db_xref="CDD:480741"
     CDS             1..167
                     /gene="TMEM229B"
                     /gene_synonym="C14orf83"
                     /coded_by="XM_047431036.1:609..1112"
                     /db_xref="GeneID:161145"
                     /db_xref="HGNC:HGNC:20130"
                     /db_xref="MIM:619022"
ORIGIN      
        1 masaepltal srwylyaihg yfcevmftaa wefvvnlnwk fpgvtsvwal fiygtsiliv
       61 ermylrlrgr cplllrcliy tlwtylweft tgfilrqfna cpwdysqfdf dfmglitley
      121 avpwfcgali meqfiirntl rlrfdkdaep gepsgalala nghvktd
//
LOCUS       XP_047286993             167 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 229B isoform X1 [Homo sapiens].
ACCESSION   XP_047286993
VERSION     XP_047286993.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431037.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..167
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..167
                     /product="transmembrane protein 229B isoform X1"
                     /calculated_mol_wt=19400
     Region          <50..>135
                     /region_name="ABC_trans_CmpB"
                     /note="Putative ABC-transporter type IV; cl46401"
                     /db_xref="CDD:480741"
     CDS             1..167
                     /gene="TMEM229B"
                     /gene_synonym="C14orf83"
                     /coded_by="XM_047431037.1:387..890"
                     /db_xref="GeneID:161145"
                     /db_xref="HGNC:HGNC:20130"
                     /db_xref="MIM:619022"
ORIGIN      
        1 masaepltal srwylyaihg yfcevmftaa wefvvnlnwk fpgvtsvwal fiygtsiliv
       61 ermylrlrgr cplllrcliy tlwtylweft tgfilrqfna cpwdysqfdf dfmglitley
      121 avpwfcgali meqfiirntl rlrfdkdaep gepsgalala nghvktd
//
LOCUS       XP_047286994             167 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 229B isoform X1 [Homo sapiens].
ACCESSION   XP_047286994
VERSION     XP_047286994.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431038.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..167
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..167
                     /product="transmembrane protein 229B isoform X1"
                     /calculated_mol_wt=19400
     Region          <50..>135
                     /region_name="ABC_trans_CmpB"
                     /note="Putative ABC-transporter type IV; cl46401"
                     /db_xref="CDD:480741"
     CDS             1..167
                     /gene="TMEM229B"
                     /gene_synonym="C14orf83"
                     /coded_by="XM_047431038.1:698..1201"
                     /db_xref="GeneID:161145"
                     /db_xref="HGNC:HGNC:20130"
                     /db_xref="MIM:619022"
ORIGIN      
        1 masaepltal srwylyaihg yfcevmftaa wefvvnlnwk fpgvtsvwal fiygtsiliv
       61 ermylrlrgr cplllrcliy tlwtylweft tgfilrqfna cpwdysqfdf dfmglitley
      121 avpwfcgali meqfiirntl rlrfdkdaep gepsgalala nghvktd
//
LOCUS       XP_016876547             373 aa            linear   PRI 05-AUG-2025
DEFINITION  GTP-binding protein REM 2 isoform X1 [Homo sapiens].
ACCESSION   XP_016876547
VERSION     XP_016876547.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021058.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..373
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..373
                     /product="GTP-binding protein REM 2 isoform X1"
                     /calculated_mol_wt=40515
     Region          147..373
                     /region_name="RGK"
                     /note="Rem, Rem2, Rad, Gem/Kir (RGK) subfamily of Ras
                     GTPases; cd04148"
                     /db_xref="CDD:206715"
     Site            153..160
                     /site_type="other"
                     /note="G1 box"
                     /db_xref="CDD:206715"
     Site            order(154..155,204..205)
                     /site_type="other"
                     /note="putative GDI interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:206715"
     Site            order(155..161,202,205,262..263,265,292..293)
                     /site_type="other"
                     /note="GTP/Mg2+ binding site [chemical binding]"
                     /db_xref="CDD:206715"
     Site            order(160..161,173,175,185..186,199..200,202,204..205,294)
                     /site_type="other"
                     /note="putative GEF interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:206715"
     Site            order(174..175,183..186)
                     /site_type="active"
                     /note="putative effector interaction site [active]"
                     /db_xref="CDD:206715"
     Site            order(174..179,182..185)
                     /site_type="other"
                     /note="Switch I region"
                     /db_xref="CDD:206715"
     Site            176
                     /site_type="other"
                     /note="G2 box"
                     /db_xref="CDD:206715"
     Site            202..205
                     /site_type="other"
                     /note="G3 box"
                     /db_xref="CDD:206715"
     Site            order(204..205,214..217,220..223)
                     /site_type="other"
                     /note="Switch II region"
                     /db_xref="CDD:206715"
     Site            262..265
                     /site_type="other"
                     /note="G4 box"
                     /db_xref="CDD:206715"
     Site            292..294
                     /site_type="other"
                     /note="G5 box"
                     /db_xref="CDD:206715"
     Site            367..370
                     /site_type="other"
                     /note="putative lipid modification site [posttranslational
                     modification]"
                     /db_xref="CDD:206715"
     CDS             1..373
                     /gene="REM2"
                     /coded_by="XM_017021058.2:1065..2186"
                     /db_xref="GeneID:161253"
                     /db_xref="HGNC:HGNC:20248"
                     /db_xref="MIM:616955"
ORIGIN      
        1 mstpvqasgd fsvrgqarhs qfllgnghqv gvagplileq pglsllhmve hipliasfsl
       61 pshfileada tllkksekll aeldrsglps apgaprrrgs mpvpykhqlr raqavdeldw
      121 ppqasssgss dslgsgeaap aqkdgifkvm lvgesgvgks tlagtfgglq gdsahepenp
      181 aedtyerrim vdkeevtlvv ydiweqgdag gwlrdhclqt gdaflivfsv tdrrsfskvp
      241 etllrlragr phhdlpvilv gnksdlarsr evsleegrhl agtlsckhie tsaalhhntr
      301 elfegavrqi rlrrgrnhag gqrpdpgspe gpapparres ltkkakrfla nlvprnakff
      361 kqrsrschdl svl
//
LOCUS       XP_016876548             372 aa            linear   PRI 05-AUG-2025
DEFINITION  GTP-binding protein REM 2 isoform X2 [Homo sapiens].
ACCESSION   XP_016876548
VERSION     XP_016876548.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021059.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..372
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..372
                     /product="GTP-binding protein REM 2 isoform X2"
                     /calculated_mol_wt=40444
     Region          147..372
                     /region_name="RGK"
                     /note="Rem, Rem2, Rad, Gem/Kir (RGK) subfamily of Ras
                     GTPases; cd04148"
                     /db_xref="CDD:206715"
     Site            153..160
                     /site_type="other"
                     /note="G1 box"
                     /db_xref="CDD:206715"
     Site            order(154..155,203..204)
                     /site_type="other"
                     /note="putative GDI interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:206715"
     Site            order(155..161,201,204,261..262,264,291..292)
                     /site_type="other"
                     /note="GTP/Mg2+ binding site [chemical binding]"
                     /db_xref="CDD:206715"
     Site            order(160..161,173,175,184..185,198..199,201,203..204,293)
                     /site_type="other"
                     /note="putative GEF interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:206715"
     Site            order(174..175,182..185)
                     /site_type="active"
                     /note="putative effector interaction site [active]"
                     /db_xref="CDD:206715"
     Site            order(174..179,181..184)
                     /site_type="other"
                     /note="Switch I region"
                     /db_xref="CDD:206715"
     Site            176
                     /site_type="other"
                     /note="G2 box"
                     /db_xref="CDD:206715"
     Site            201..204
                     /site_type="other"
                     /note="G3 box"
                     /db_xref="CDD:206715"
     Site            order(203..204,213..216,219..222)
                     /site_type="other"
                     /note="Switch II region"
                     /db_xref="CDD:206715"
     Site            261..264
                     /site_type="other"
                     /note="G4 box"
                     /db_xref="CDD:206715"
     Site            291..293
                     /site_type="other"
                     /note="G5 box"
                     /db_xref="CDD:206715"
     Site            366..369
                     /site_type="other"
                     /note="putative lipid modification site [posttranslational
                     modification]"
                     /db_xref="CDD:206715"
     CDS             1..372
                     /gene="REM2"
                     /coded_by="XM_017021059.2:1065..2183"
                     /db_xref="GeneID:161253"
                     /db_xref="HGNC:HGNC:20248"
                     /db_xref="MIM:616955"
ORIGIN      
        1 mstpvqasgd fsvrgqarhs qfllgnghqv gvagplileq pglsllhmve hipliasfsl
       61 pshfileada tllkksekll aeldrsglps apgaprrrgs mpvpykhqlr raqavdeldw
      121 ppqasssgss dslgsgeaap aqkdgifkvm lvgesgvgks tlagtfgglq gdsahepenp
      181 edtyerrimv dkeevtlvvy diweqgdagg wlrdhclqtg daflivfsvt drrsfskvpe
      241 tllrlragrp hhdlpvilvg nksdlarsre vsleegrhla gtlsckhiet saalhhntre
      301 lfegavrqir lrrgrnhagg qrpdpgspeg papparresl tkkakrflan lvprnakffk
      361 qrsrschdls vl
//
LOCUS       XP_047287001             351 aa            linear   PRI 05-AUG-2025
DEFINITION  GTP-binding protein REM 2 isoform X3 [Homo sapiens].
ACCESSION   XP_047287001
VERSION     XP_047287001.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431045.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..351
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..351
                     /product="GTP-binding protein REM 2 isoform X3"
                     /calculated_mol_wt=36964
     Region          115..>153
                     /region_name="P-loop containing Nucleoside Triphosphate
                     Hydrolases"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; cl38936"
                     /db_xref="CDD:476819"
     Site            121..128
                     /site_type="other"
                     /note="G1 box"
                     /db_xref="CDD:206648"
     Site            145
                     /site_type="other"
                     /note="G2 box"
                     /db_xref="CDD:206648"
     Site            149..151
                     /site_type="other"
                     /note="Switch I region"
                     /db_xref="CDD:206648"
     CDS             1..351
                     /gene="REM2"
                     /coded_by="XM_047431045.1:67..1122"
                     /db_xref="GeneID:161253"
                     /db_xref="HGNC:HGNC:20248"
                     /db_xref="MIM:616955"
ORIGIN      
        1 mhtdldtdmd mdtettalcp sgsrrasppg tptpeadatl lkksekllae ldrsglpsap
       61 gaprrrgsmp vpykhqlrra qavdeldwpp qasssgssds lgsgeaapaq kdgifkvmlv
      121 gesgvgkstl agtfgglqgd sahepenpgg crrvaagplp sdrgrlshrl lshrpteflq
      181 ssrdptsapg weaaprptry prwkqerlgp lpggitgggp ppgrdaelqa hrdvgrtapq
      241 hegalrgrga pdpaaagpkp rrrpearsgq prgpcatctp rephqesqev prqpgaaqrq
      301 vlqaalqvvs rplgalsrgr hghcgrhghr alrspplapp rprpaslvea v
//
LOCUS       XP_047287002             343 aa            linear   PRI 05-AUG-2025
DEFINITION  GTP-binding protein REM 2 isoform X4 [Homo sapiens].
ACCESSION   XP_047287002
VERSION     XP_047287002.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431046.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..343
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..343
                     /product="GTP-binding protein REM 2 isoform X4"
                     /calculated_mol_wt=36861
     Region          147..343
                     /region_name="P-loop containing Nucleoside Triphosphate
                     Hydrolases"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; cl38936"
                     /db_xref="CDD:476819"
     Site            153..160
                     /site_type="other"
                     /note="G1 box"
                     /db_xref="CDD:206648"
     Site            177
                     /site_type="other"
                     /note="G2 box"
                     /db_xref="CDD:206648"
     Site            181..183
                     /site_type="other"
                     /note="Switch I region"
                     /db_xref="CDD:206648"
     Site            262..264
                     /site_type="other"
                     /note="G5 box"
                     /db_xref="CDD:206648"
     CDS             1..343
                     /gene="REM2"
                     /coded_by="XM_047431046.1:1065..2096"
                     /db_xref="GeneID:161253"
                     /db_xref="HGNC:HGNC:20248"
                     /db_xref="MIM:616955"
ORIGIN      
        1 mstpvqasgd fsvrgqarhs qfllgnghqv gvagplileq pglsllhmve hipliasfsl
       61 pshfileada tllkksekll aeldrsglps apgaprrrgs mpvpykhqlr raqavdeldw
      121 ppqasssgss dslgsgeaap aqkdgifkvm lvgesgvgks tlagtfgglq gdsahepenp
      181 ggcrrvaagp lpsdrgrlsh rllshrptef lqssrdptsa pgweaaprpt ryprwkqerl
      241 gplpgegrhl agtlsckhie tsaalhhntr elfegavrqi rlrrgrnhag gqrpdpgspe
      301 gpapparres ltkkakrfla nlvprnakff kqrsrschdl svl
//
LOCUS       XP_005267440             341 aa            linear   PRI 05-AUG-2025
DEFINITION  GTP-binding protein REM 2 isoform X5 [Homo sapiens].
ACCESSION   XP_005267440
VERSION     XP_005267440.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267383.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..341
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..341
                     /product="GTP-binding protein REM 2 isoform X5"
                     /calculated_mol_wt=37079
     Region          115..341
                     /region_name="RGK"
                     /note="Rem, Rem2, Rad, Gem/Kir (RGK) subfamily of Ras
                     GTPases; cd04148"
                     /db_xref="CDD:206715"
     Site            121..128
                     /site_type="other"
                     /note="G1 box"
                     /db_xref="CDD:206715"
     Site            order(122..123,172..173)
                     /site_type="other"
                     /note="putative GDI interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:206715"
     Site            order(123..129,170,173,230..231,233,260..261)
                     /site_type="other"
                     /note="GTP/Mg2+ binding site [chemical binding]"
                     /db_xref="CDD:206715"
     Site            order(128..129,141,143,153..154,167..168,170,172..173,262)
                     /site_type="other"
                     /note="putative GEF interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:206715"
     Site            order(142..143,151..154)
                     /site_type="active"
                     /note="putative effector interaction site [active]"
                     /db_xref="CDD:206715"
     Site            order(142..147,150..153)
                     /site_type="other"
                     /note="Switch I region"
                     /db_xref="CDD:206715"
     Site            144
                     /site_type="other"
                     /note="G2 box"
                     /db_xref="CDD:206715"
     Site            170..173
                     /site_type="other"
                     /note="G3 box"
                     /db_xref="CDD:206715"
     Site            order(172..173,182..185,188..191)
                     /site_type="other"
                     /note="Switch II region"
                     /db_xref="CDD:206715"
     Site            230..233
                     /site_type="other"
                     /note="G4 box"
                     /db_xref="CDD:206715"
     Site            260..262
                     /site_type="other"
                     /note="G5 box"
                     /db_xref="CDD:206715"
     Site            335..338
                     /site_type="other"
                     /note="putative lipid modification site [posttranslational
                     modification]"
                     /db_xref="CDD:206715"
     CDS             1..341
                     /gene="REM2"
                     /coded_by="XM_005267383.4:67..1092"
                     /db_xref="GeneID:161253"
                     /db_xref="HGNC:HGNC:20248"
                     /db_xref="MIM:616955"
ORIGIN      
        1 mhtdldtdmd mdtettalcp sgsrrasppg tptpeadatl lkksekllae ldrsglpsap
       61 gaprrrgsmp vpykhqlrra qavdeldwpp qasssgssds lgsgeaapaq kdgifkvmlv
      121 gesgvgkstl agtfgglqgd sahepenpae dtyerrimvd keevtlvvyd iweqgdaggw
      181 lrdhclqtgd aflivfsvtd rrsfskvpet llrlragrph hdlpvilvgn ksdlarsrev
      241 sleegrhlag tlsckhiets aalhhntrel fegavrqirl rrgrnhaggq rpdpgspegp
      301 apparreslt kkakrflanl vprnakffkq rsrschdlsv l
//
LOCUS       XP_011534820             279 aa            linear   PRI 05-AUG-2025
DEFINITION  GTP-binding protein REM 2 isoform X6 [Homo sapiens].
ACCESSION   XP_011534820
VERSION     XP_011534820.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536518.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..279
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..279
                     /product="GTP-binding protein REM 2 isoform X6"
                     /calculated_mol_wt=30047
     Region          147..>271
                     /region_name="P-loop containing Nucleoside Triphosphate
                     Hydrolases"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; cl38936"
                     /db_xref="CDD:476819"
     Site            153..160
                     /site_type="other"
                     /note="G1 box"
                     /db_xref="CDD:206715"
     Site            177
                     /site_type="other"
                     /note="G2 box"
                     /db_xref="CDD:206715"
     Site            183..185
                     /site_type="other"
                     /note="Switch I region"
                     /db_xref="CDD:206715"
     Site            202..205
                     /site_type="other"
                     /note="G3 box"
                     /db_xref="CDD:206715"
     Site            order(204..205,222..223)
                     /site_type="other"
                     /note="Switch II region"
                     /db_xref="CDD:206715"
     Site            262..265
                     /site_type="other"
                     /note="G4 box"
                     /db_xref="CDD:206715"
     CDS             1..279
                     /gene="REM2"
                     /coded_by="XM_011536518.3:1065..1904"
                     /db_xref="GeneID:161253"
                     /db_xref="HGNC:HGNC:20248"
                     /db_xref="MIM:616955"
ORIGIN      
        1 mstpvqasgd fsvrgqarhs qfllgnghqv gvagplileq pglsllhmve hipliasfsl
       61 pshfileada tllkksekll aeldrsglps apgaprrrgs mpvpykhqlr raqavdeldw
      121 ppqasssgss dslgsgeaap aqkdgifkvm lvgesgvgks tlagtfgglq gdsahepenp
      181 aedtyerrim vdkeevtlvv ydiweqgdag gwlrdhclqt gdaflivfsv tdrrsfskvp
      241 etllrlragr phhdlpvilv gnksdlarsr eraatwpgr
//
LOCUS       XP_047287003             278 aa            linear   PRI 05-AUG-2025
DEFINITION  GTP-binding protein REM 2 isoform X7 [Homo sapiens].
ACCESSION   XP_047287003
VERSION     XP_047287003.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431047.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..278
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..278
                     /product="GTP-binding protein REM 2 isoform X7"
                     /calculated_mol_wt=29976
     Region          147..>270
                     /region_name="P-loop containing Nucleoside Triphosphate
                     Hydrolases"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; cl38936"
                     /db_xref="CDD:476819"
     Site            153..160
                     /site_type="other"
                     /note="G1 box"
                     /db_xref="CDD:206648"
     Site            177
                     /site_type="other"
                     /note="G2 box"
                     /db_xref="CDD:206648"
     Site            182..184
                     /site_type="other"
                     /note="Switch I region"
                     /db_xref="CDD:206648"
     Site            201..204
                     /site_type="other"
                     /note="G3 box"
                     /db_xref="CDD:206648"
     Site            order(203..204,221..222)
                     /site_type="other"
                     /note="Switch II region"
                     /db_xref="CDD:206648"
     Site            261..264
                     /site_type="other"
                     /note="G4 box"
                     /db_xref="CDD:206648"
     CDS             1..278
                     /gene="REM2"
                     /coded_by="XM_047431047.1:1065..1901"
                     /db_xref="GeneID:161253"
                     /db_xref="HGNC:HGNC:20248"
                     /db_xref="MIM:616955"
ORIGIN      
        1 mstpvqasgd fsvrgqarhs qfllgnghqv gvagplileq pglsllhmve hipliasfsl
       61 pshfileada tllkksekll aeldrsglps apgaprrrgs mpvpykhqlr raqavdeldw
      121 ppqasssgss dslgsgeaap aqkdgifkvm lvgesgvgks tlagtfgglq gdsahepenp
      181 edtyerrimv dkeevtlvvy diweqgdagg wlrdhclqtg daflivfsvt drrsfskvpe
      241 tllrlragrp hhdlpvilvg nksdlarsre raatwpgr
//
LOCUS       XP_011534821             980 aa            linear   PRI 05-AUG-2025
DEFINITION  MAM domain-containing glycosylphosphatidylinositol anchor protein 2
            isoform X1 [Homo sapiens].
ACCESSION   XP_011534821
VERSION     XP_011534821.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536519.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..980
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..980
                     /product="MAM domain-containing
                     glycosylphosphatidylinositol anchor protein 2 isoform X1"
                     /calculated_mol_wt=109871
     Region          72..152
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          82..86
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          95..99
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          117..121
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          131..136
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          158..243
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     Region          275..338
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     Region          373..448
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          379..383
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          394..398
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          424..428
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          438..443
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          452..455
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          465..542
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     Region          772..943
                     /region_name="MAM"
                     /note="Meprin, A5 protein, and protein tyrosine
                     phosphatase Mu (MAM) domain. MAM is an extracellular
                     domain which mediates protein-protein interactions and is
                     found in a diverse set of proteins, many of which are
                     known to function in cell adhesion. Members...; cd06263"
                     /db_xref="CDD:99706"
     CDS             1..980
                     /gene="MDGA2"
                     /gene_synonym="c14_5286; MAMDC1"
                     /coded_by="XM_011536519.3:5060..8002"
                     /db_xref="GeneID:161357"
                     /db_xref="HGNC:HGNC:19835"
                     /db_xref="MIM:611128"
ORIGIN      
        1 mfkyeslgic rrthgsaacf shsvadspev afcqaklpfl ppttvtseap ptvrivhsgl
       61 acnieeerys ervytirege tleltclvtg hprpqirwtk tagsasdrfq dssvfnetlr
      121 itniqrhqgg ryyckaengl gspaiksirv dvyylddpvv tvhqsigeak eqfyyertvf
      181 lrcvansnpp vryswrrgqe vllqgsdkgv eiyepfftqg etkilklknl rpqdyanysc
      241 iasvrnvcni pdkmvsfrls nktaspsikl lvddpivvnp geaitlvcvt tggepapslt
      301 wvrsfgtlpe ktvlnggtlt ipaitsddag tysciannnv gnpakkstni ivralkkgrf
      361 witpdpyhkd dniqigrevk iscqveavps eeltfswfkn grplrsserm vitqtdpdvs
      421 pgttnldiid lkftdfgtyt cvaslkgggi sdisidvnis sstvppnltv pqeksplvtr
      481 egdtielqcq vtgkpkpiil wsradkevam pdgsmqmesy dgtlrivnvs remsgmyrcq
      541 tsqyngfnvk prealvqliv qyppavepaf leirqgqdrs vtmscrvlra ypirvltyew
      601 rlgnkllrtg qfdsqeytey avkslsneny gvyncsiine agagrcsflv tgkayapefy
      661 ydtynpvwqn rhrvysyslq wtqmnpdavd rivayrlgir qagqqrwweq eikingniqk
      721 gelitynlte likpeayevr ltpltkfgeg dstirvikys apvnphlref hcgfedgnic
      781 lftqddtdnf dwtkqstatr ntkytpntgp nadrsgskeg fymyietsrp rlegekarll
      841 spvfsiapkn pygptntayc fsffyhmygq higvlnvylr lkgqttienp lwsssgnkgq
      901 rwneahvniy pitsfqlife girgpgiegd iaiddvsiae gecakqdlat knsvdgavgi
      961 lvhiwlfpii vlisilsprr
//
LOCUS       XP_047287004             727 aa            linear   PRI 05-AUG-2025
DEFINITION  MAM domain-containing glycosylphosphatidylinositol anchor protein 2
            isoform X2 [Homo sapiens].
ACCESSION   XP_047287004
VERSION     XP_047287004.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431048.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..727
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..727
                     /product="MAM domain-containing
                     glycosylphosphatidylinositol anchor protein 2 isoform X2"
                     /calculated_mol_wt=81233
     Region          22..85
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     Region          120..195
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          126..130
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          141..145
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          171..175
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          185..190
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          199..202
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          212..289
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     Region          519..690
                     /region_name="MAM"
                     /note="Meprin, A5 protein, and protein tyrosine
                     phosphatase Mu (MAM) domain. MAM is an extracellular
                     domain which mediates protein-protein interactions and is
                     found in a diverse set of proteins, many of which are
                     known to function in cell adhesion. Members...; cd06263"
                     /db_xref="CDD:99706"
     CDS             1..727
                     /gene="MDGA2"
                     /gene_synonym="c14_5286; MAMDC1"
                     /coded_by="XM_047431048.1:764..2947"
                     /db_xref="GeneID:161357"
                     /db_xref="HGNC:HGNC:19835"
                     /db_xref="MIM:611128"
ORIGIN      
        1 mvsfrlsnkt aspsikllvd dpivvnpgea itlvcvttgg epapsltwvr sfgtlpektv
       61 lnggtltipa itsddagtys ciannnvgnp akkstniivr alkkgrfwit pdpyhkddni
      121 qigrevkisc qveavpseel tfswfkngrp lrssermvit qtdpdvspgt tnldiidlkf
      181 tdfgtytcva slkgggisdi sidvnissst vppnltvpqe ksplvtregd tielqcqvtg
      241 kpkpiilwsr adkevampdg smqmesydgt lrivnvsrem sgmyrcqtsq yngfnvkpre
      301 alvqlivqyp pavepaflei rqgqdrsvtm scrvlraypi rvltyewrlg nkllrtgqfd
      361 sqeyteyavk slsnenygvy ncsiineaga grcsflvtgk ayapefyydt ynpvwqnrhr
      421 vysyslqwtq mnpdavdriv ayrlgirqag qqrwweqeik ingniqkgel itynltelik
      481 peayevrltp ltkfgegdst irvikysapv nphlrefhcg fedgniclft qddtdnfdwt
      541 kqstatrntk ytpntgpnad rsgskegfym yietsrprle gekarllspv fsiapknpyg
      601 ptntaycfsf fyhmygqhig vlnvylrlkg qttienplws ssgnkgqrwn eahvniypit
      661 sfqlifegir gpgiegdiai ddvsiaegec akqdlatkns vdgavgilvh iwlfpiivli
      721 silsprr
//
LOCUS       XP_047287005             727 aa            linear   PRI 05-AUG-2025
DEFINITION  MAM domain-containing glycosylphosphatidylinositol anchor protein 2
            isoform X2 [Homo sapiens].
ACCESSION   XP_047287005
VERSION     XP_047287005.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431049.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..727
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..727
                     /product="MAM domain-containing
                     glycosylphosphatidylinositol anchor protein 2 isoform X2"
                     /calculated_mol_wt=81233
     Region          22..85
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     Region          120..195
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          126..130
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          141..145
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          171..175
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          185..190
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          199..202
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          212..289
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     Region          519..690
                     /region_name="MAM"
                     /note="Meprin, A5 protein, and protein tyrosine
                     phosphatase Mu (MAM) domain. MAM is an extracellular
                     domain which mediates protein-protein interactions and is
                     found in a diverse set of proteins, many of which are
                     known to function in cell adhesion. Members...; cd06263"
                     /db_xref="CDD:99706"
     CDS             1..727
                     /gene="MDGA2"
                     /gene_synonym="c14_5286; MAMDC1"
                     /coded_by="XM_047431049.1:830..3013"
                     /db_xref="GeneID:161357"
                     /db_xref="HGNC:HGNC:19835"
                     /db_xref="MIM:611128"
ORIGIN      
        1 mvsfrlsnkt aspsikllvd dpivvnpgea itlvcvttgg epapsltwvr sfgtlpektv
       61 lnggtltipa itsddagtys ciannnvgnp akkstniivr alkkgrfwit pdpyhkddni
      121 qigrevkisc qveavpseel tfswfkngrp lrssermvit qtdpdvspgt tnldiidlkf
      181 tdfgtytcva slkgggisdi sidvnissst vppnltvpqe ksplvtregd tielqcqvtg
      241 kpkpiilwsr adkevampdg smqmesydgt lrivnvsrem sgmyrcqtsq yngfnvkpre
      301 alvqlivqyp pavepaflei rqgqdrsvtm scrvlraypi rvltyewrlg nkllrtgqfd
      361 sqeyteyavk slsnenygvy ncsiineaga grcsflvtgk ayapefyydt ynpvwqnrhr
      421 vysyslqwtq mnpdavdriv ayrlgirqag qqrwweqeik ingniqkgel itynltelik
      481 peayevrltp ltkfgegdst irvikysapv nphlrefhcg fedgniclft qddtdnfdwt
      541 kqstatrntk ytpntgpnad rsgskegfym yietsrprle gekarllspv fsiapknpyg
      601 ptntaycfsf fyhmygqhig vlnvylrlkg qttienplws ssgnkgqrwn eahvniypit
      661 sfqlifegir gpgiegdiai ddvsiaegec akqdlatkns vdgavgilvh iwlfpiivli
      721 silsprr
//
LOCUS       XP_047287006             727 aa            linear   PRI 05-AUG-2025
DEFINITION  MAM domain-containing glycosylphosphatidylinositol anchor protein 2
            isoform X2 [Homo sapiens].
ACCESSION   XP_047287006
VERSION     XP_047287006.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431050.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..727
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..727
                     /product="MAM domain-containing
                     glycosylphosphatidylinositol anchor protein 2 isoform X2"
                     /calculated_mol_wt=81233
     Region          22..85
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     Region          120..195
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          126..130
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          141..145
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          171..175
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          185..190
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          199..202
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          212..289
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     Region          519..690
                     /region_name="MAM"
                     /note="Meprin, A5 protein, and protein tyrosine
                     phosphatase Mu (MAM) domain. MAM is an extracellular
                     domain which mediates protein-protein interactions and is
                     found in a diverse set of proteins, many of which are
                     known to function in cell adhesion. Members...; cd06263"
                     /db_xref="CDD:99706"
     CDS             1..727
                     /gene="MDGA2"
                     /gene_synonym="c14_5286; MAMDC1"
                     /coded_by="XM_047431050.1:672..2855"
                     /db_xref="GeneID:161357"
                     /db_xref="HGNC:HGNC:19835"
                     /db_xref="MIM:611128"
ORIGIN      
        1 mvsfrlsnkt aspsikllvd dpivvnpgea itlvcvttgg epapsltwvr sfgtlpektv
       61 lnggtltipa itsddagtys ciannnvgnp akkstniivr alkkgrfwit pdpyhkddni
      121 qigrevkisc qveavpseel tfswfkngrp lrssermvit qtdpdvspgt tnldiidlkf
      181 tdfgtytcva slkgggisdi sidvnissst vppnltvpqe ksplvtregd tielqcqvtg
      241 kpkpiilwsr adkevampdg smqmesydgt lrivnvsrem sgmyrcqtsq yngfnvkpre
      301 alvqlivqyp pavepaflei rqgqdrsvtm scrvlraypi rvltyewrlg nkllrtgqfd
      361 sqeyteyavk slsnenygvy ncsiineaga grcsflvtgk ayapefyydt ynpvwqnrhr
      421 vysyslqwtq mnpdavdriv ayrlgirqag qqrwweqeik ingniqkgel itynltelik
      481 peayevrltp ltkfgegdst irvikysapv nphlrefhcg fedgniclft qddtdnfdwt
      541 kqstatrntk ytpntgpnad rsgskegfym yietsrprle gekarllspv fsiapknpyg
      601 ptntaycfsf fyhmygqhig vlnvylrlkg qttienplws ssgnkgqrwn eahvniypit
      661 sfqlifegir gpgiegdiai ddvsiaegec akqdlatkns vdgavgilvh iwlfpiivli
      721 silsprr
//
LOCUS       XP_011534824             621 aa            linear   PRI 05-AUG-2025
DEFINITION  MAM domain-containing glycosylphosphatidylinositol anchor protein 2
            isoform X3 [Homo sapiens].
ACCESSION   XP_011534824
VERSION     XP_011534824.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536522.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..621
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..621
                     /product="MAM domain-containing
                     glycosylphosphatidylinositol anchor protein 2 isoform X3"
                     /calculated_mol_wt=69045
     Region          115..183
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     Region          203..288
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     Region          320..383
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     Region          418..493
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          424..428
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          439..443
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          469..473
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          483..488
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          497..500
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          510..587
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     CDS             1..621
                     /gene="MDGA2"
                     /gene_synonym="c14_5286; MAMDC1"
                     /coded_by="XM_011536522.4:810..2675"
                     /db_xref="GeneID:161357"
                     /db_xref="HGNC:HGNC:19835"
                     /db_xref="MIM:611128"
ORIGIN      
        1 msvwsagllr sarrrrrgrt dgrrfllrra vpghlglara rverawlaag llkvplrtpw
       61 agyvhvhvkm dllyglvwll tvllegisgq gvyapptvri vhsglacnie eeryservyt
      121 iregetlelt clvtghprpq irwtktagsa sdrfqdssvf netlritniq rhqggryyck
      181 aenglgspai ksirvdvyyl ddpvvtvhqs igeakeqfyy ertvflrcva nsnppvrysw
      241 rrgqevllqg sdkgveiyep fftqgetkil klknlrpqdy anysciasvr nvcnipdkmv
      301 sfrlsnktas psikllvddp ivvnpgeait lvcvttggep apsltwvrsf gtlpektvln
      361 ggtltipait sddagtysci annnvgnpak kstniivral kkgrfwitpd pyhkddniqi
      421 grevkiscqv eavpseeltf swfkngrplr ssermvitqt dpdvspgttn ldiidlkftd
      481 fgtytcvasl kgggisdisi dvnissstvp pnltvpqeks plvtregdti elqcqvtgkp
      541 kpiilwsrad kevampdgsm qmesydgtlr ivnvsremsg myrcqtsqyn gfnvkpreal
      601 vqlivqccfa stleltikih l
//
LOCUS       XP_016876549             571 aa            linear   PRI 05-AUG-2025
DEFINITION  MAM domain-containing glycosylphosphatidylinositol anchor protein 2
            isoform X4 [Homo sapiens].
ACCESSION   XP_016876549
VERSION     XP_016876549.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021060.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..571
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..571
                     /product="MAM domain-containing
                     glycosylphosphatidylinositol anchor protein 2 isoform X4"
                     /calculated_mol_wt=64309
     Region          56..133
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     Region          363..534
                     /region_name="MAM"
                     /note="Meprin, A5 protein, and protein tyrosine
                     phosphatase Mu (MAM) domain. MAM is an extracellular
                     domain which mediates protein-protein interactions and is
                     found in a diverse set of proteins, many of which are
                     known to function in cell adhesion. Members...; cd06263"
                     /db_xref="CDD:99706"
     CDS             1..571
                     /gene="MDGA2"
                     /gene_synonym="c14_5286; MAMDC1"
                     /coded_by="XM_017021060.2:487..2202"
                     /db_xref="GeneID:161357"
                     /db_xref="HGNC:HGNC:19835"
                     /db_xref="MIM:611128"
ORIGIN      
        1 mvitqtdpdv spgttnldii dlkftdfgty tcvaslkggg isdisidvni ssstvppnlt
       61 vpqeksplvt regdtielqc qvtgkpkpii lwsradkeva mpdgsmqmes ydgtlrivnv
      121 sremsgmyrc qtsqyngfnv kprealvqli vqyppavepa fleirqgqdr svtmscrvlr
      181 aypirvltye wrlgnkllrt gqfdsqeyte yavkslsnen ygvyncsiin eagagrcsfl
      241 vtgkayapef yydtynpvwq nrhrvysysl qwtqmnpdav drivayrlgi rqagqqrwwe
      301 qeikingniq kgelitynlt elikpeayev rltpltkfge gdstirviky sapvnphlre
      361 fhcgfedgni clftqddtdn fdwtkqstat rntkytpntg pnadrsgske gfymyietsr
      421 prlegekarl lspvfsiapk npygptntay cfsffyhmyg qhigvlnvyl rlkgqttien
      481 plwsssgnkg qrwneahvni ypitsfqlif egirgpgieg diaiddvsia egecakqdla
      541 tknsvdgavg ilvhiwlfpi ivlisilspr r
//
LOCUS       XP_047287007             531 aa            linear   PRI 05-AUG-2025
DEFINITION  MAM domain-containing glycosylphosphatidylinositol anchor protein 2
            isoform X5 [Homo sapiens].
ACCESSION   XP_047287007
VERSION     XP_047287007.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431051.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..531
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..531
                     /product="MAM domain-containing
                     glycosylphosphatidylinositol anchor protein 2 isoform X5"
                     /calculated_mol_wt=59083
     Region          115..183
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     Region          203..288
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     Region          320..383
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     Region          418..493
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          424..428
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          439..443
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          469..473
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          483..488
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          497..500
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     CDS             1..531
                     /gene="MDGA2"
                     /gene_synonym="c14_5286; MAMDC1"
                     /coded_by="XM_047431051.1:810..2405"
                     /db_xref="GeneID:161357"
                     /db_xref="HGNC:HGNC:19835"
                     /db_xref="MIM:611128"
ORIGIN      
        1 msvwsagllr sarrrrrgrt dgrrfllrra vpghlglara rverawlaag llkvplrtpw
       61 agyvhvhvkm dllyglvwll tvllegisgq gvyapptvri vhsglacnie eeryservyt
      121 iregetlelt clvtghprpq irwtktagsa sdrfqdssvf netlritniq rhqggryyck
      181 aenglgspai ksirvdvyyl ddpvvtvhqs igeakeqfyy ertvflrcva nsnppvrysw
      241 rrgqevllqg sdkgveiyep fftqgetkil klknlrpqdy anysciasvr nvcnipdkmv
      301 sfrlsnktas psikllvddp ivvnpgeait lvcvttggep apsltwvrsf gtlpektvln
      361 ggtltipait sddagtysci annnvgnpak kstniivral kkgrfwitpd pyhkddniqi
      421 grevkiscqv eavpseeltf swfkngrplr ssermvitqt dpdvspgttn ldiidlkftd
      481 fgtytcvasl kgggisdisi dvnissstgk itighqrrrh nrtamssnwq t
//
LOCUS       XP_016876550             526 aa            linear   PRI 05-AUG-2025
DEFINITION  MAM domain-containing glycosylphosphatidylinositol anchor protein 2
            isoform X6 [Homo sapiens].
ACCESSION   XP_016876550
VERSION     XP_016876550.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021061.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..526
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..526
                     /product="MAM domain-containing
                     glycosylphosphatidylinositol anchor protein 2 isoform X6"
                     /calculated_mol_wt=58562
     Region          115..183
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     Region          203..288
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     Region          320..383
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     Region          418..493
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          424..428
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          439..443
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          469..473
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          483..488
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          497..500
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     CDS             1..526
                     /gene="MDGA2"
                     /gene_synonym="c14_5286; MAMDC1"
                     /coded_by="XM_017021061.3:810..2390"
                     /db_xref="GeneID:161357"
                     /db_xref="HGNC:HGNC:19835"
                     /db_xref="MIM:611128"
ORIGIN      
        1 msvwsagllr sarrrrrgrt dgrrfllrra vpghlglara rverawlaag llkvplrtpw
       61 agyvhvhvkm dllyglvwll tvllegisgq gvyapptvri vhsglacnie eeryservyt
      121 iregetlelt clvtghprpq irwtktagsa sdrfqdssvf netlritniq rhqggryyck
      181 aenglgspai ksirvdvyyl ddpvvtvhqs igeakeqfyy ertvflrcva nsnppvrysw
      241 rrgqevllqg sdkgveiyep fftqgetkil klknlrpqdy anysciasvr nvcnipdkmv
      301 sfrlsnktas psikllvddp ivvnpgeait lvcvttggep apsltwvrsf gtlpektvln
      361 ggtltipait sddagtysci annnvgnpak kstniivral kkgrfwitpd pyhkddniqi
      421 grevkiscqv eavpseeltf swfkngrplr ssermvitqt dpdvspgttn ldiidlkftd
      481 fgtytcvasl kgggisdisi dvnissstdg ltqeenkkqs yycprr
//
LOCUS       XP_011534827             516 aa            linear   PRI 05-AUG-2025
DEFINITION  MAM domain-containing glycosylphosphatidylinositol anchor protein 2
            isoform X7 [Homo sapiens].
ACCESSION   XP_011534827
VERSION     XP_011534827.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536525.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..516
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..516
                     /product="MAM domain-containing
                     glycosylphosphatidylinositol anchor protein 2 isoform X7"
                     /calculated_mol_wt=58644
     Region          11..76
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          21..25
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          34..38
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          58..62
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          72..77
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          308..479
                     /region_name="MAM"
                     /note="Meprin, A5 protein, and protein tyrosine
                     phosphatase Mu (MAM) domain. MAM is an extracellular
                     domain which mediates protein-protein interactions and is
                     found in a diverse set of proteins, many of which are
                     known to function in cell adhesion. Members...; cd06263"
                     /db_xref="CDD:99706"
     CDS             1..516
                     /gene="MDGA2"
                     /gene_synonym="c14_5286; MAMDC1"
                     /coded_by="XM_011536525.3:97..1647"
                     /db_xref="GeneID:161357"
                     /db_xref="HGNC:HGNC:19835"
                     /db_xref="MIM:611128"
ORIGIN      
        1 mliypaaqek splvtregdt ielqcqvtgk pkpiilwsra dkevampdgs mqmesydgtl
       61 rivnvsrems gmyrcqtsqy ngfnvkprea lvqlivqypp avepafleir qgqdrsvtms
      121 crvlraypir vltyewrlgn kllrtgqfds qeyteyavks lsnenygvyn csiineagag
      181 rcsflvtgka yapefyydty npvwqnrhrv ysyslqwtqm npdavdriva yrlgirqagq
      241 qrwweqeiki ngniqkgeli tynltelikp eayevrltpl tkfgegdsti rvikysapvn
      301 phlrefhcgf edgniclftq ddtdnfdwtk qstatrntky tpntgpnadr sgskegfymy
      361 ietsrprleg ekarllspvf siapknpygp tntaycfsff yhmygqhigv lnvylrlkgq
      421 ttienplwss sgnkgqrwne ahvniypits fqlifegirg pgiegdiaid dvsiaegeca
      481 kqdlatknsv dgavgilvhi wlfpiivlis ilsprr
//
LOCUS       XP_047287008             650 aa            linear   PRI 05-AUG-2025
DEFINITION  nucleolar protein 9 isoform X1 [Homo sapiens].
ACCESSION   XP_047287008
VERSION     XP_047287008.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431052.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..650
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..650
                     /product="nucleolar protein 9 isoform X1"
                     /calculated_mol_wt=70768
     Region          526..>614
                     /region_name="Pumilio"
                     /note="Pumilio-family RNA binding domain; cl46378"
                     /db_xref="CDD:480718"
     CDS             1..650
                     /gene="NOP9"
                     /gene_synonym="C14orf21; HP08474"
                     /coded_by="XM_047431052.1:1769..3721"
                     /db_xref="GeneID:161424"
                     /db_xref="HGNC:HGNC:19826"
                     /db_xref="MIM:618308"
ORIGIN      
        1 mgqgprsphk vgrrfpaggk rgrgakgsgr plpgrkrqpw pppdgrsepa pdshphlspe
       61 algyfrrals alkeapetge erdlmvhnim kevetqalal stnrtgseml qellgfsplk
      121 plcrvwaalr snlrtvachr cgvhvlqsal lqlprllgsa aeeeeeeeed gkdgptetle
      181 elvlglaaev cddflvycgd thgsfvvrtl lqvlggtile serarprgsq ssvcdlptah
      241 vlnlpseaqk tpaqeckpad fevpetflnr lqdlsssflk diavfitdki ssfclqvalq
      301 vlhrklpqfc ahlcnavigy lstrgssvdg splllflrdq tssrlleqvl lvlepprlqs
      361 lfeehlqgql qtlaahpian fplqrlldav ttpellspvf eelspvleav laqghpgvvi
      421 alvgacrrvg ayqakvlqll leafhcaeps srqvacvplf atlmayevyy glteeegavp
      481 aehqvamaaa ralgdvtvlg slllqhllhf stpglvlrsl galtgpqlls laqspagshv
      541 ldailtspsv trklrrrvlq nlkgqyvala csrhgsrvld aiwsgaalra rkeiaaelge
      601 qnqelirdpf ghhvarnval ttflkrreaw eqqqgavakr rralnsiled
//
LOCUS       XP_047287009             650 aa            linear   PRI 05-AUG-2025
DEFINITION  nucleolar protein 9 isoform X1 [Homo sapiens].
ACCESSION   XP_047287009
VERSION     XP_047287009.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431053.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..650
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..650
                     /product="nucleolar protein 9 isoform X1"
                     /calculated_mol_wt=70768
     Region          526..>614
                     /region_name="Pumilio"
                     /note="Pumilio-family RNA binding domain; cl46378"
                     /db_xref="CDD:480718"
     CDS             1..650
                     /gene="NOP9"
                     /gene_synonym="C14orf21; HP08474"
                     /coded_by="XM_047431053.1:1853..3805"
                     /db_xref="GeneID:161424"
                     /db_xref="HGNC:HGNC:19826"
                     /db_xref="MIM:618308"
ORIGIN      
        1 mgqgprsphk vgrrfpaggk rgrgakgsgr plpgrkrqpw pppdgrsepa pdshphlspe
       61 algyfrrals alkeapetge erdlmvhnim kevetqalal stnrtgseml qellgfsplk
      121 plcrvwaalr snlrtvachr cgvhvlqsal lqlprllgsa aeeeeeeeed gkdgptetle
      181 elvlglaaev cddflvycgd thgsfvvrtl lqvlggtile serarprgsq ssvcdlptah
      241 vlnlpseaqk tpaqeckpad fevpetflnr lqdlsssflk diavfitdki ssfclqvalq
      301 vlhrklpqfc ahlcnavigy lstrgssvdg splllflrdq tssrlleqvl lvlepprlqs
      361 lfeehlqgql qtlaahpian fplqrlldav ttpellspvf eelspvleav laqghpgvvi
      421 alvgacrrvg ayqakvlqll leafhcaeps srqvacvplf atlmayevyy glteeegavp
      481 aehqvamaaa ralgdvtvlg slllqhllhf stpglvlrsl galtgpqlls laqspagshv
      541 ldailtspsv trklrrrvlq nlkgqyvala csrhgsrvld aiwsgaalra rkeiaaelge
      601 qnqelirdpf ghhvarnval ttflkrreaw eqqqgavakr rralnsiled
//
LOCUS       XP_047287010             650 aa            linear   PRI 05-AUG-2025
DEFINITION  nucleolar protein 9 isoform X1 [Homo sapiens].
ACCESSION   XP_047287010
VERSION     XP_047287010.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431054.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..650
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..650
                     /product="nucleolar protein 9 isoform X1"
                     /calculated_mol_wt=70768
     Region          526..>614
                     /region_name="Pumilio"
                     /note="Pumilio-family RNA binding domain; cl46378"
                     /db_xref="CDD:480718"
     CDS             1..650
                     /gene="NOP9"
                     /gene_synonym="C14orf21; HP08474"
                     /coded_by="XM_047431054.1:1928..3880"
                     /db_xref="GeneID:161424"
                     /db_xref="HGNC:HGNC:19826"
                     /db_xref="MIM:618308"
ORIGIN      
        1 mgqgprsphk vgrrfpaggk rgrgakgsgr plpgrkrqpw pppdgrsepa pdshphlspe
       61 algyfrrals alkeapetge erdlmvhnim kevetqalal stnrtgseml qellgfsplk
      121 plcrvwaalr snlrtvachr cgvhvlqsal lqlprllgsa aeeeeeeeed gkdgptetle
      181 elvlglaaev cddflvycgd thgsfvvrtl lqvlggtile serarprgsq ssvcdlptah
      241 vlnlpseaqk tpaqeckpad fevpetflnr lqdlsssflk diavfitdki ssfclqvalq
      301 vlhrklpqfc ahlcnavigy lstrgssvdg splllflrdq tssrlleqvl lvlepprlqs
      361 lfeehlqgql qtlaahpian fplqrlldav ttpellspvf eelspvleav laqghpgvvi
      421 alvgacrrvg ayqakvlqll leafhcaeps srqvacvplf atlmayevyy glteeegavp
      481 aehqvamaaa ralgdvtvlg slllqhllhf stpglvlrsl galtgpqlls laqspagshv
      541 ldailtspsv trklrrrvlq nlkgqyvala csrhgsrvld aiwsgaalra rkeiaaelge
      601 qnqelirdpf ghhvarnval ttflkrreaw eqqqgavakr rralnsiled
//
LOCUS       XP_005267442             650 aa            linear   PRI 05-AUG-2025
DEFINITION  nucleolar protein 9 isoform X1 [Homo sapiens].
ACCESSION   XP_005267442
VERSION     XP_005267442.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267385.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..650
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..650
                     /product="nucleolar protein 9 isoform X1"
                     /calculated_mol_wt=70768
     Region          526..>614
                     /region_name="Pumilio"
                     /note="Pumilio-family RNA binding domain; cl46378"
                     /db_xref="CDD:480718"
     CDS             1..650
                     /gene="NOP9"
                     /gene_synonym="C14orf21; HP08474"
                     /coded_by="XM_005267385.2:1450..3402"
                     /db_xref="GeneID:161424"
                     /db_xref="HGNC:HGNC:19826"
                     /db_xref="MIM:618308"
ORIGIN      
        1 mgqgprsphk vgrrfpaggk rgrgakgsgr plpgrkrqpw pppdgrsepa pdshphlspe
       61 algyfrrals alkeapetge erdlmvhnim kevetqalal stnrtgseml qellgfsplk
      121 plcrvwaalr snlrtvachr cgvhvlqsal lqlprllgsa aeeeeeeeed gkdgptetle
      181 elvlglaaev cddflvycgd thgsfvvrtl lqvlggtile serarprgsq ssvcdlptah
      241 vlnlpseaqk tpaqeckpad fevpetflnr lqdlsssflk diavfitdki ssfclqvalq
      301 vlhrklpqfc ahlcnavigy lstrgssvdg splllflrdq tssrlleqvl lvlepprlqs
      361 lfeehlqgql qtlaahpian fplqrlldav ttpellspvf eelspvleav laqghpgvvi
      421 alvgacrrvg ayqakvlqll leafhcaeps srqvacvplf atlmayevyy glteeegavp
      481 aehqvamaaa ralgdvtvlg slllqhllhf stpglvlrsl galtgpqlls laqspagshv
      541 ldailtspsv trklrrrvlq nlkgqyvala csrhgsrvld aiwsgaalra rkeiaaelge
      601 qnqelirdpf ghhvarnval ttflkrreaw eqqqgavakr rralnsiled
//
LOCUS       XP_047287011             650 aa            linear   PRI 05-AUG-2025
DEFINITION  nucleolar protein 9 isoform X1 [Homo sapiens].
ACCESSION   XP_047287011
VERSION     XP_047287011.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431055.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..650
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..650
                     /product="nucleolar protein 9 isoform X1"
                     /calculated_mol_wt=70768
     Region          526..>614
                     /region_name="Pumilio"
                     /note="Pumilio-family RNA binding domain; cl46378"
                     /db_xref="CDD:480718"
     CDS             1..650
                     /gene="NOP9"
                     /gene_synonym="C14orf21; HP08474"
                     /coded_by="XM_047431055.1:1614..3566"
                     /db_xref="GeneID:161424"
                     /db_xref="HGNC:HGNC:19826"
                     /db_xref="MIM:618308"
ORIGIN      
        1 mgqgprsphk vgrrfpaggk rgrgakgsgr plpgrkrqpw pppdgrsepa pdshphlspe
       61 algyfrrals alkeapetge erdlmvhnim kevetqalal stnrtgseml qellgfsplk
      121 plcrvwaalr snlrtvachr cgvhvlqsal lqlprllgsa aeeeeeeeed gkdgptetle
      181 elvlglaaev cddflvycgd thgsfvvrtl lqvlggtile serarprgsq ssvcdlptah
      241 vlnlpseaqk tpaqeckpad fevpetflnr lqdlsssflk diavfitdki ssfclqvalq
      301 vlhrklpqfc ahlcnavigy lstrgssvdg splllflrdq tssrlleqvl lvlepprlqs
      361 lfeehlqgql qtlaahpian fplqrlldav ttpellspvf eelspvleav laqghpgvvi
      421 alvgacrrvg ayqakvlqll leafhcaeps srqvacvplf atlmayevyy glteeegavp
      481 aehqvamaaa ralgdvtvlg slllqhllhf stpglvlrsl galtgpqlls laqspagshv
      541 ldailtspsv trklrrrvlq nlkgqyvala csrhgsrvld aiwsgaalra rkeiaaelge
      601 qnqelirdpf ghhvarnval ttflkrreaw eqqqgavakr rralnsiled
//
LOCUS       XP_011534828             566 aa            linear   PRI 05-AUG-2025
DEFINITION  nucleolar protein 9 isoform X2 [Homo sapiens].
ACCESSION   XP_011534828
VERSION     XP_011534828.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536526.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..566
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..566
                     /product="nucleolar protein 9 isoform X2"
                     /calculated_mol_wt=61689
     Region          442..>530
                     /region_name="Pumilio"
                     /note="Pumilio-family RNA binding domain; cl46378"
                     /db_xref="CDD:480718"
     CDS             1..566
                     /gene="NOP9"
                     /gene_synonym="C14orf21; HP08474"
                     /coded_by="XM_011536526.3:141..1841"
                     /db_xref="GeneID:161424"
                     /db_xref="HGNC:HGNC:19826"
                     /db_xref="MIM:618308"
ORIGIN      
        1 mvhnimkeve tqalalstnr tgsemlqell gfsplkplcr vwaalrsnlr tvachrcgvh
       61 vlqsallqlp rllgsaaeee eeeeedgkdg ptetleelvl glaaevcddf lvycgdthgs
      121 fvvrtllqvl ggtilesera rprgsqssvc dlptahvlnl pseaqktpaq eckpadfevp
      181 etflnrlqdl sssflkdiav fitdkissfc lqvalqvlhr klpqfcahlc navigylstr
      241 gssvdgspll lflrdqtssr lleqvllvle pprlqslfee hlqgqlqtla ahpianfplq
      301 rlldavttpe llspvfeels pvleavlaqg hpgvvialvg acrrvgayqa kvlqllleaf
      361 hcaepssrqv acvplfatlm ayevyyglte eegavpaehq vamaaaralg dvtvlgslll
      421 qhllhfstpg lvlrslgalt gpqllslaqs pagshvldai ltspsvtrkl rrrvlqnlkg
      481 qyvalacsrh gsrvldaiws gaalrarkei aaelgeqnqe lirdpfghhv arnvalttfl
      541 krreaweqqq gavakrrral nsiled
//
LOCUS       XP_011534829             397 aa            linear   PRI 05-AUG-2025
DEFINITION  nucleolar protein 9 isoform X3 [Homo sapiens].
ACCESSION   XP_011534829
VERSION     XP_011534829.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536527.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..397
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..397
                     /product="nucleolar protein 9 isoform X3"
                     /calculated_mol_wt=43488
     CDS             1..397
                     /gene="NOP9"
                     /gene_synonym="C14orf21; HP08474"
                     /coded_by="XM_011536527.3:106..1299"
                     /db_xref="GeneID:161424"
                     /db_xref="HGNC:HGNC:19826"
                     /db_xref="MIM:618308"
ORIGIN      
        1 mgqgprsphk vgrrfpaggk rgrgakgsgr plpgrkrqpw pppdgrsepa pdshphlspe
       61 algyfrrals alkeapetge erdlmvhnim kevetqalal stnrtgseml qellgfsplk
      121 plcrvwaalr snlrtvachr cgvhvlqsal lqlprllgsa aeeeeeeeed gkdgptetle
      181 elvlglaaev cddflvycgd thgsfvvrtl lqvlggtile serarprgsq ssvcdlptah
      241 vlnlpseaqk tpaqeckpad fevpetflnr lqdlsssflk diavfitdki ssfclqvalq
      301 vlhrklpqfc ahlcnavigy lstrgssvdg splllflrdq tssrlleqvl lvlepprlqs
      361 lfeehlqgql qtlaahpian fplqrlldav ttpelhf
//
LOCUS       XP_011534830            2002 aa            linear   PRI 05-AUG-2025
DEFINITION  echinoderm microtubule-associated protein-like 5 isoform X1 [Homo
            sapiens].
ACCESSION   XP_011534830
VERSION     XP_011534830.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536528.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2002
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2002
                     /product="echinoderm microtubule-associated protein-like 5
                     isoform X1"
                     /calculated_mol_wt=223214
     Region          <2..49
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          58..438
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          64..104
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          110..148
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          153..201
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          203..233
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          240..273
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          286..321
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          328..352
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          369..401
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          411..451
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          521..564
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          <672..715
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          725..1063
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Site            order(726,744,750,756..757,769..770,789,793,801..802,
                     814..815,834,839,843..844,862,879,884,890,901..902,918,
                     922,928..929,995..996,1014,1019,1025..1026,1038..1039,
                     1057,1061)
                     /site_type="active"
                     /note="structural tetrad [active]"
                     /db_xref="CDD:238121"
     Region          730..769
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          776..814
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          819..861
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          895..1266
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          907..939
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          941..994
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1002..1037
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1043..1078
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1085..1122
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1193..1235
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1339..1410
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          1426..1475
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1428..1815
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          1480..1522
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1524..1567
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1573..1608
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1613..1698
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1697..1953
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          1705..1743
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1788..1821
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1834..1892
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1900..1934
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..2002
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /coded_by="XM_011536528.4:451..6459"
                     /db_xref="GeneID:161436"
                     /db_xref="HGNC:HGNC:18197"
                     /db_xref="MIM:618119"
ORIGIN      
        1 maarsapsch lrlewvygyr ghqcrnnlyy taakeivyfv agvgvvyspr ehrqkfyrgh
       61 sddiislalh pervlvatgq vgkepyiciw dsytvqtisv lkdvhthgia clafdldgqr
      121 lvsvgldskn avcvwdwkrg kmlsmapght drifdiswdl yqpnklvscg vkhikfwslc
      181 gnaltpkrgv fgktgdlqti lclacardel tysgalngdi yvwkginlir tiqgahaagi
      241 fsmnaceegf atggrdgcir lwdltfkpit vidlretdqg ykglsvrsvc wrgdhilvgt
      301 qdseifeivv qernkpflim qghcegelwa lavhptkpla vtgsddrsvr iwslvdhali
      361 arcnmeepir caavnadgih lalgmkdgsf tvlrvrdmte vvhikdrkea ihelkyspdg
      421 tylavgcnds svdiygvaqr ykkvgeclgs lsfithldws sdsrylqtnd gngkrlfyrm
      481 pggkevtste eikgvhwasw tcvsglevng iwpkysdind insvdgnyig qvlvtaddyg
      541 iiklfrypcl rkgakfrkyi ghsahvtnvr wshdyqwvis iggadhsvfq wkfiperklk
      601 davhiapqes ladshsdesd sdlsdvpeld seieqetqlt yrrqvykedl pqlkeqckek
      661 qksatskrre rapgnsirlh fvhgyrgydc rsnlfytqig eivyhvaavg viynrqqntq
      721 rfylghdddi lcltihplkd yvatgqvgrd psihiwdtet ikplsilkgh hqygvsavdf
      781 sadgkrlasv giddshtvvl wdwkkgekls iargskdkif vvkmnpyvpd klitagikhm
      841 kfwrkagggl igrkgyigtl gkndtmmcav ygwteemafs gtstgdvciw rdiflvktvk
      901 ahdgpvfsmh alekgfvtgg kdgivalwdd sferclktya ikraalapgs kglllednps
      961 iraislghgh ilvgtkngei levdksgpit llvqghmege vwglathpyl picatvsddk
     1021 tlriwdlsps hcmlavrklk kggrcccfsp dgkalavgln dgsflmanad tledlvsfhh
     1081 rkdmisdirf spgsgkylav ashdsfidiy nvmsskrvgi ckgatsyith idwdirgkll
     1141 qvntgakeql ffeaprgkkq tipsveveki awaswtsvlg lccegiwpvi gevtdvtasc
     1201 ltsdkmvlat gddlgfvklf ryptkgkfgk fkryvahsth vtnvrwtydd smlvtlggtd
     1261 mslmvwtnem egyrekrpcd seesdidsee dggydsdvtr eneisytira lstnirpmlg
     1321 ikphlqqkep siderqgvvr gsrppvsrap pqpeklqtnn vgkkkrpied lvlelifgyr
     1381 grdcrnnvhy lndgddiiyh tasvgilhnv atgsqsfyqe hnddilcltv nqhpkfiniv
     1441 atgqvgdsad msatapsihi wdamnkqtls ilrcyhskgv csvsfsatgk lllsvgldpe
     1501 htitiwrwqe gakiasragh nqrifvaefr pdsdtqfvsv gvkhvkfwtl agrallskkg
     1561 llstledarm qtmlaiafga nnltftgtis gdvcvwkdhi lcrivarahn gpvfamyttl
     1621 rdglivtggk erpskeggav klwdqelrrc rafrletgqa tdcvrsvcrg kgkilvgtrn
     1681 aeiievgekn aacnilvngh vdgpiwglat hpsrdfflsa aedgtvrlwd iadkkmlnkv
     1741 nlghaartvc yspegdmvai gmkngefiil lvsslkiwgk krdrrcaihd irfspdsryl
     1801 avgssensvd fydltlgptl nrisyckdip sfviqmdfsa dssylqvssg cykrhvyevp
     1861 sgkhlmdhaa idritwatwt silgdevlgi wsrhaekadv ncacvshsgi slvtgddfgm
     1921 vklfdfpcpe kfvslcfvyy yqftpnfdvl ssalfpiylk cfvliskffp klsksiyfei
     1981 kairnkssps sntifgtilq kl
//
LOCUS       XP_011534832            1999 aa            linear   PRI 05-AUG-2025
DEFINITION  echinoderm microtubule-associated protein-like 5 isoform X2 [Homo
            sapiens].
ACCESSION   XP_011534832
VERSION     XP_011534832.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536530.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1999
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1999
                     /product="echinoderm microtubule-associated protein-like 5
                     isoform X2"
                     /calculated_mol_wt=222914
     Region          <2..49
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          58..438
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          64..104
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          110..148
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          153..201
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          203..233
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          240..273
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          286..321
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          328..352
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          369..401
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          411..451
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          521..564
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          <672..715
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          725..1063
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Site            order(726,744,750,756..757,769..770,789,793,801..802,
                     814..815,834,839,843..844,862,879,884,890,901..902,918,
                     922,928..929,995..996,1014,1019,1025..1026,1038..1039,
                     1057,1061)
                     /site_type="active"
                     /note="structural tetrad [active]"
                     /db_xref="CDD:238121"
     Region          730..769
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          776..814
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          819..861
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          895..1266
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          907..939
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          941..994
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1002..1037
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1043..1078
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1085..1122
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1193..1235
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1335..1407
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          1423..1472
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1425..1812
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          1477..1519
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1521..1564
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1570..1605
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1610..1695
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1694..1950
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          1702..1740
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1785..1818
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1831..1889
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1897..1931
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..1999
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /coded_by="XM_011536530.4:451..6450"
                     /db_xref="GeneID:161436"
                     /db_xref="HGNC:HGNC:18197"
                     /db_xref="MIM:618119"
ORIGIN      
        1 maarsapsch lrlewvygyr ghqcrnnlyy taakeivyfv agvgvvyspr ehrqkfyrgh
       61 sddiislalh pervlvatgq vgkepyiciw dsytvqtisv lkdvhthgia clafdldgqr
      121 lvsvgldskn avcvwdwkrg kmlsmapght drifdiswdl yqpnklvscg vkhikfwslc
      181 gnaltpkrgv fgktgdlqti lclacardel tysgalngdi yvwkginlir tiqgahaagi
      241 fsmnaceegf atggrdgcir lwdltfkpit vidlretdqg ykglsvrsvc wrgdhilvgt
      301 qdseifeivv qernkpflim qghcegelwa lavhptkpla vtgsddrsvr iwslvdhali
      361 arcnmeepir caavnadgih lalgmkdgsf tvlrvrdmte vvhikdrkea ihelkyspdg
      421 tylavgcnds svdiygvaqr ykkvgeclgs lsfithldws sdsrylqtnd gngkrlfyrm
      481 pggkevtste eikgvhwasw tcvsglevng iwpkysdind insvdgnyig qvlvtaddyg
      541 iiklfrypcl rkgakfrkyi ghsahvtnvr wshdyqwvis iggadhsvfq wkfiperklk
      601 davhiapqes ladshsdesd sdlsdvpeld seieqetqlt yrrqvykedl pqlkeqckek
      661 qksatskrre rapgnsirlh fvhgyrgydc rsnlfytqig eivyhvaavg viynrqqntq
      721 rfylghdddi lcltihplkd yvatgqvgrd psihiwdtet ikplsilkgh hqygvsavdf
      781 sadgkrlasv giddshtvvl wdwkkgekls iargskdkif vvkmnpyvpd klitagikhm
      841 kfwrkagggl igrkgyigtl gkndtmmcav ygwteemafs gtstgdvciw rdiflvktvk
      901 ahdgpvfsmh alekgfvtgg kdgivalwdd sferclktya ikraalapgs kglllednps
      961 iraislghgh ilvgtkngei levdksgpit llvqghmege vwglathpyl picatvsddk
     1021 tlriwdlsps hcmlavrklk kggrcccfsp dgkalavgln dgsflmanad tledlvsfhh
     1081 rkdmisdirf spgsgkylav ashdsfidiy nvmsskrvgi ckgatsyith idwdirgkll
     1141 qvntgakeql ffeaprgkkq tipsveveki awaswtsvlg lccegiwpvi gevtdvtasc
     1201 ltsdkmvlat gddlgfvklf ryptkgkfgk fkryvahsth vtnvrwtydd smlvtlggtd
     1261 mslmvwtnem egyrekrpcd seesdidsee dggydsdvtr eneisytira lstnirpmlg
     1321 ikphlqqkep siderqgvvr ppvsrappqp eklqtnnvgk kkrpiedlvl elifgyrgrd
     1381 crnnvhylnd gddiiyhtas vgilhnvatg sqsfyqehnd dilcltvnqh pkfinivatg
     1441 qvgdsadmsa tapsihiwda mnkqtlsilr cyhskgvcsv sfsatgklll svgldpehti
     1501 tiwrwqegak iasraghnqr ifvaefrpds dtqfvsvgvk hvkfwtlagr allskkglls
     1561 tledarmqtm laiafgannl tftgtisgdv cvwkdhilcr ivarahngpv famyttlrdg
     1621 livtggkerp skeggavklw dqelrrcraf rletgqatdc vrsvcrgkgk ilvgtrnaei
     1681 ievgeknaac nilvnghvdg piwglathps rdfflsaaed gtvrlwdiad kkmlnkvnlg
     1741 haartvcysp egdmvaigmk ngefiillvs slkiwgkkrd rrcaihdirf spdsrylavg
     1801 ssensvdfyd ltlgptlnri syckdipsfv iqmdfsadss ylqvssgcyk rhvyevpsgk
     1861 hlmdhaaidr itwatwtsil gdevlgiwsr haekadvnca cvshsgislv tgddfgmvkl
     1921 fdfpcpekfv slcfvyyyqf tpnfdvlssa lfpiylkcfv liskffpkls ksiyfeikai
     1981 rnksspssnt ifgtilqkl
//
LOCUS       XP_016876551            1997 aa            linear   PRI 05-AUG-2025
DEFINITION  echinoderm microtubule-associated protein-like 5 isoform X3 [Homo
            sapiens].
ACCESSION   XP_016876551
VERSION     XP_016876551.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021062.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1997
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1997
                     /product="echinoderm microtubule-associated protein-like 5
                     isoform X3"
                     /calculated_mol_wt=222346
     Region          <2..49
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          58..438
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          64..104
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          110..148
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          153..201
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          203..233
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          240..273
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          286..321
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          328..352
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          369..401
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          411..451
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          521..564
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          <672..715
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          725..1063
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Site            order(726,744,750,756..757,769..770,789,793,801..802,
                     814..815,834,839,843..844,862,879,884,890,901..902,918,
                     922,928..929,995..996,1014,1019,1025..1026,1038..1039,
                     1057,1061)
                     /site_type="active"
                     /note="structural tetrad [active]"
                     /db_xref="CDD:238121"
     Region          730..769
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          776..814
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          819..861
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          895..1266
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          907..939
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          941..994
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1002..1037
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1043..1078
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1085..1122
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1193..1235
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1339..1410
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          1426..1475
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1428..1815
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          1480..1518
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1524..1567
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1573..1608
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1613..1698
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1697..1975
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Site            order(1700,1719,1723,1729..1730,1743..1744,1760,1764,1778,
                     1780,1801,1806,1812..1813,1826,1848,1853,1857..1858,
                     1895..1896,1914,1918,1924..1925,1940..1941,1959,1964,
                     1972..1973)
                     /site_type="active"
                     /note="structural tetrad [active]"
                     /db_xref="CDD:238121"
     Region          1705..1743
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1788..1821
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1834..1892
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1900..1939
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..1997
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /coded_by="XM_017021062.3:451..6444"
                     /db_xref="GeneID:161436"
                     /db_xref="HGNC:HGNC:18197"
                     /db_xref="MIM:618119"
ORIGIN      
        1 maarsapsch lrlewvygyr ghqcrnnlyy taakeivyfv agvgvvyspr ehrqkfyrgh
       61 sddiislalh pervlvatgq vgkepyiciw dsytvqtisv lkdvhthgia clafdldgqr
      121 lvsvgldskn avcvwdwkrg kmlsmapght drifdiswdl yqpnklvscg vkhikfwslc
      181 gnaltpkrgv fgktgdlqti lclacardel tysgalngdi yvwkginlir tiqgahaagi
      241 fsmnaceegf atggrdgcir lwdltfkpit vidlretdqg ykglsvrsvc wrgdhilvgt
      301 qdseifeivv qernkpflim qghcegelwa lavhptkpla vtgsddrsvr iwslvdhali
      361 arcnmeepir caavnadgih lalgmkdgsf tvlrvrdmte vvhikdrkea ihelkyspdg
      421 tylavgcnds svdiygvaqr ykkvgeclgs lsfithldws sdsrylqtnd gngkrlfyrm
      481 pggkevtste eikgvhwasw tcvsglevng iwpkysdind insvdgnyig qvlvtaddyg
      541 iiklfrypcl rkgakfrkyi ghsahvtnvr wshdyqwvis iggadhsvfq wkfiperklk
      601 davhiapqes ladshsdesd sdlsdvpeld seieqetqlt yrrqvykedl pqlkeqckek
      661 qksatskrre rapgnsirlh fvhgyrgydc rsnlfytqig eivyhvaavg viynrqqntq
      721 rfylghdddi lcltihplkd yvatgqvgrd psihiwdtet ikplsilkgh hqygvsavdf
      781 sadgkrlasv giddshtvvl wdwkkgekls iargskdkif vvkmnpyvpd klitagikhm
      841 kfwrkagggl igrkgyigtl gkndtmmcav ygwteemafs gtstgdvciw rdiflvktvk
      901 ahdgpvfsmh alekgfvtgg kdgivalwdd sferclktya ikraalapgs kglllednps
      961 iraislghgh ilvgtkngei levdksgpit llvqghmege vwglathpyl picatvsddk
     1021 tlriwdlsps hcmlavrklk kggrcccfsp dgkalavgln dgsflmanad tledlvsfhh
     1081 rkdmisdirf spgsgkylav ashdsfidiy nvmsskrvgi ckgatsyith idwdirgkll
     1141 qvntgakeql ffeaprgkkq tipsveveki awaswtsvlg lccegiwpvi gevtdvtasc
     1201 ltsdkmvlat gddlgfvklf ryptkgkfgk fkryvahsth vtnvrwtydd smlvtlggtd
     1261 mslmvwtnem egyrekrpcd seesdidsee dggydsdvtr eneisytira lstnirpmlg
     1321 ikphlqqkep siderqgvvr gsrppvsrap pqpeklqtnn vgkkkrpied lvlelifgyr
     1381 grdcrnnvhy lndgddiiyh tasvgilhnv atgsqsfyqe hnddilcltv nqhpkfiniv
     1441 atgqvgdsad msatapsihi wdamnkqtls ilrcyhskgv csvsfsatgk lllsvgldpe
     1501 htitiwrwqe gakiasragh nqrifvaefr pdsdtqfvsv gvkhvkfwtl agrallskkg
     1561 llstledarm qtmlaiafga nnltftgtis gdvcvwkdhi lcrivarahn gpvfamyttl
     1621 rdglivtggk erpskeggav klwdqelrrc rafrletgqa tdcvrsvcrg kgkilvgtrn
     1681 aeiievgekn aacnilvngh vdgpiwglat hpsrdfflsa aedgtvrlwd iadkkmlnkv
     1741 nlghaartvc yspegdmvai gmkngefiil lvsslkiwgk krdrrcaihd irfspdsryl
     1801 avgssensvd fydltlgptl nrisyckdip sfviqmdfsa dssylqvssg cykrhvyevp
     1861 sgkhlmdhaa idritwatwt silgdevlgi wsrhaekadv ncacvshsgi slvtgddfgm
     1921 vklfdfpcpe kfakhkrflg hsphvtnirf tsgdrhvvsa ggddcrlvtf saheeqtmll
     1981 vkrlntttpt alvyeis
//
LOCUS       XP_016876552            1995 aa            linear   PRI 05-AUG-2025
DEFINITION  echinoderm microtubule-associated protein-like 5 isoform X4 [Homo
            sapiens].
ACCESSION   XP_016876552
VERSION     XP_016876552.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021063.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1995
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1995
                     /product="echinoderm microtubule-associated protein-like 5
                     isoform X4"
                     /calculated_mol_wt=222551
     Region          <2..49
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          58..438
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          64..104
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          110..148
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          153..201
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          203..233
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          240..273
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          286..321
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          328..352
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          369..401
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          411..451
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          521..564
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          <672..715
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          725..1063
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Site            order(726,744,750,756..757,769..770,789,793,801..802,
                     814..815,834,839,843..844,862,879,884,890,901..902,918,
                     922,928..929,995..996,1014,1019,1025..1026,1038..1039,
                     1057,1061)
                     /site_type="active"
                     /note="structural tetrad [active]"
                     /db_xref="CDD:238121"
     Region          730..769
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          776..814
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          819..861
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          895..1266
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          907..939
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          941..994
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1002..1037
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1043..1078
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1085..1122
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1193..1235
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1339..1410
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          1426..1468
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          <1445..1808
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          1473..1511
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1517..1560
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1566..1601
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1606..1691
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1690..1946
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          1698..1736
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1781..1814
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1827..1885
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1893..1927
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..1995
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /coded_by="XM_017021063.3:451..6438"
                     /db_xref="GeneID:161436"
                     /db_xref="HGNC:HGNC:18197"
                     /db_xref="MIM:618119"
ORIGIN      
        1 maarsapsch lrlewvygyr ghqcrnnlyy taakeivyfv agvgvvyspr ehrqkfyrgh
       61 sddiislalh pervlvatgq vgkepyiciw dsytvqtisv lkdvhthgia clafdldgqr
      121 lvsvgldskn avcvwdwkrg kmlsmapght drifdiswdl yqpnklvscg vkhikfwslc
      181 gnaltpkrgv fgktgdlqti lclacardel tysgalngdi yvwkginlir tiqgahaagi
      241 fsmnaceegf atggrdgcir lwdltfkpit vidlretdqg ykglsvrsvc wrgdhilvgt
      301 qdseifeivv qernkpflim qghcegelwa lavhptkpla vtgsddrsvr iwslvdhali
      361 arcnmeepir caavnadgih lalgmkdgsf tvlrvrdmte vvhikdrkea ihelkyspdg
      421 tylavgcnds svdiygvaqr ykkvgeclgs lsfithldws sdsrylqtnd gngkrlfyrm
      481 pggkevtste eikgvhwasw tcvsglevng iwpkysdind insvdgnyig qvlvtaddyg
      541 iiklfrypcl rkgakfrkyi ghsahvtnvr wshdyqwvis iggadhsvfq wkfiperklk
      601 davhiapqes ladshsdesd sdlsdvpeld seieqetqlt yrrqvykedl pqlkeqckek
      661 qksatskrre rapgnsirlh fvhgyrgydc rsnlfytqig eivyhvaavg viynrqqntq
      721 rfylghdddi lcltihplkd yvatgqvgrd psihiwdtet ikplsilkgh hqygvsavdf
      781 sadgkrlasv giddshtvvl wdwkkgekls iargskdkif vvkmnpyvpd klitagikhm
      841 kfwrkagggl igrkgyigtl gkndtmmcav ygwteemafs gtstgdvciw rdiflvktvk
      901 ahdgpvfsmh alekgfvtgg kdgivalwdd sferclktya ikraalapgs kglllednps
      961 iraislghgh ilvgtkngei levdksgpit llvqghmege vwglathpyl picatvsddk
     1021 tlriwdlsps hcmlavrklk kggrcccfsp dgkalavgln dgsflmanad tledlvsfhh
     1081 rkdmisdirf spgsgkylav ashdsfidiy nvmsskrvgi ckgatsyith idwdirgkll
     1141 qvntgakeql ffeaprgkkq tipsveveki awaswtsvlg lccegiwpvi gevtdvtasc
     1201 ltsdkmvlat gddlgfvklf ryptkgkfgk fkryvahsth vtnvrwtydd smlvtlggtd
     1261 mslmvwtnem egyrekrpcd seesdidsee dggydsdvtr eneisytira lstnirpmlg
     1321 ikphlqqkep siderqgvvr gsrppvsrap pqpeklqtnn vgkkkrpied lvlelifgyr
     1381 grdcrnnvhy lndgddiiyh tasvgilhnv atgsqsfyqe hnddilcltv nqhpkfiniv
     1441 atgqvataps ihiwdamnkq tlsilrcyhs kgvcsvsfsa tgklllsvgl dpehtitiwr
     1501 wqegakiasr aghnqrifva efrpdsdtqf vsvgvkhvkf wtlagralls kkgllstled
     1561 armqtmlaia fgannltftg tisgdvcvwk dhilcrivar ahngpvfamy ttlrdglivt
     1621 ggkerpskeg gavklwdqel rrcrafrlet gqatdcvrsv crgkgkilvg trnaeiievg
     1681 eknaacnilv nghvdgpiwg lathpsrdff lsaaedgtvr lwdiadkkml nkvnlghaar
     1741 tvcyspegdm vaigmkngef iillvsslki wgkkrdrrca ihdirfspds rylavgssen
     1801 svdfydltlg ptlnrisyck dipsfviqmd fsadssylqv ssgcykrhvy evpsgkhlmd
     1861 haaidritwa twtsilgdev lgiwsrhaek advncacvsh sgislvtgdd fgmvklfdfp
     1921 cpekfvslcf vyyyqftpnf dvlssalfpi ylkcfvlisk ffpklsksiy feikairnks
     1981 spssntifgt ilqkl
//
LOCUS       XP_011534833            1994 aa            linear   PRI 05-AUG-2025
DEFINITION  echinoderm microtubule-associated protein-like 5 isoform X5 [Homo
            sapiens].
ACCESSION   XP_011534833
VERSION     XP_011534833.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536531.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1994
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1994
                     /product="echinoderm microtubule-associated protein-like 5
                     isoform X5"
                     /calculated_mol_wt=222375
     Region          <2..49
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          58..438
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          64..104
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          110..148
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          153..201
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          203..233
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          240..273
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          286..321
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          328..352
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          369..401
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          411..451
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          521..564
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          <672..715
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          725..1063
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Site            order(726,744,750,756..757,769..770,789,793,801..802,
                     814..815,834,839,843..844,862,879,884,890,901..902,918,
                     922,928..929,995..996,1014,1019,1025..1026,1038..1039,
                     1057,1061)
                     /site_type="active"
                     /note="structural tetrad [active]"
                     /db_xref="CDD:238121"
     Region          730..769
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          776..814
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          819..861
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          895..1266
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          907..939
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          941..994
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1002..1037
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1043..1078
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1085..1122
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1193..1235
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          <1355..1402
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          1418..1467
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1420..1807
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          1472..1510
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1516..1559
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1565..1600
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1605..1690
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1689..1945
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          1697..1735
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1780..1813
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1826..1884
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1892..1926
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..1994
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /coded_by="XM_011536531.4:451..6435"
                     /db_xref="GeneID:161436"
                     /db_xref="HGNC:HGNC:18197"
                     /db_xref="MIM:618119"
ORIGIN      
        1 maarsapsch lrlewvygyr ghqcrnnlyy taakeivyfv agvgvvyspr ehrqkfyrgh
       61 sddiislalh pervlvatgq vgkepyiciw dsytvqtisv lkdvhthgia clafdldgqr
      121 lvsvgldskn avcvwdwkrg kmlsmapght drifdiswdl yqpnklvscg vkhikfwslc
      181 gnaltpkrgv fgktgdlqti lclacardel tysgalngdi yvwkginlir tiqgahaagi
      241 fsmnaceegf atggrdgcir lwdltfkpit vidlretdqg ykglsvrsvc wrgdhilvgt
      301 qdseifeivv qernkpflim qghcegelwa lavhptkpla vtgsddrsvr iwslvdhali
      361 arcnmeepir caavnadgih lalgmkdgsf tvlrvrdmte vvhikdrkea ihelkyspdg
      421 tylavgcnds svdiygvaqr ykkvgeclgs lsfithldws sdsrylqtnd gngkrlfyrm
      481 pggkevtste eikgvhwasw tcvsglevng iwpkysdind insvdgnyig qvlvtaddyg
      541 iiklfrypcl rkgakfrkyi ghsahvtnvr wshdyqwvis iggadhsvfq wkfiperklk
      601 davhiapqes ladshsdesd sdlsdvpeld seieqetqlt yrrqvykedl pqlkeqckek
      661 qksatskrre rapgnsirlh fvhgyrgydc rsnlfytqig eivyhvaavg viynrqqntq
      721 rfylghdddi lcltihplkd yvatgqvgrd psihiwdtet ikplsilkgh hqygvsavdf
      781 sadgkrlasv giddshtvvl wdwkkgekls iargskdkif vvkmnpyvpd klitagikhm
      841 kfwrkagggl igrkgyigtl gkndtmmcav ygwteemafs gtstgdvciw rdiflvktvk
      901 ahdgpvfsmh alekgfvtgg kdgivalwdd sferclktya ikraalapgs kglllednps
      961 iraislghgh ilvgtkngei levdksgpit llvqghmege vwglathpyl picatvsddk
     1021 tlriwdlsps hcmlavrklk kggrcccfsp dgkalavgln dgsflmanad tledlvsfhh
     1081 rkdmisdirf spgsgkylav ashdsfidiy nvmsskrvgi ckgatsyith idwdirgkll
     1141 qvntgakeql ffeaprgkkq tipsveveki awaswtsvlg lccegiwpvi gevtdvtasc
     1201 ltsdkmvlat gddlgfvklf ryptkgkfgk fkryvahsth vtnvrwtydd smlvtlggtd
     1261 mslmvwtnem egyrekrpcd seesdidsee dggydsdvtr eneisytira lstnirpmlg
     1321 ikphlqqkep siderppvsr appqpeklqt nnvgkkkrpi edlvlelifg yrgrdcrnnv
     1381 hylndgddii yhtasvgilh nvatgsqsfy qehnddilcl tvnqhpkfin ivatgqvgds
     1441 admsatapsi hiwdamnkqt lsilrcyhsk gvcsvsfsat gklllsvgld pehtitiwrw
     1501 qegakiasra ghnqrifvae frpdsdtqfv svgvkhvkfw tlagrallsk kgllstleda
     1561 rmqtmlaiaf gannltftgt isgdvcvwkd hilcrivara hngpvfamyt tlrdglivtg
     1621 gkerpskegg avklwdqelr rcrafrletg qatdcvrsvc rgkgkilvgt rnaeiievge
     1681 knaacnilvn ghvdgpiwgl athpsrdffl saaedgtvrl wdiadkkmln kvnlghaart
     1741 vcyspegdmv aigmkngefi illvsslkiw gkkrdrrcai hdirfspdsr ylavgssens
     1801 vdfydltlgp tlnrisyckd ipsfviqmdf sadssylqvs sgcykrhvye vpsgkhlmdh
     1861 aaidritwat wtsilgdevl giwsrhaeka dvncacvshs gislvtgddf gmvklfdfpc
     1921 pekfvslcfv yyyqftpnfd vlssalfpiy lkcfvliskf fpklsksiyf eikairnkss
     1981 pssntifgti lqkl
//
LOCUS       XP_011534834            1994 aa            linear   PRI 05-AUG-2025
DEFINITION  echinoderm microtubule-associated protein-like 5 isoform X6 [Homo
            sapiens].
ACCESSION   XP_011534834
VERSION     XP_011534834.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536532.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1994
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1994
                     /product="echinoderm microtubule-associated protein-like 5
                     isoform X6"
                     /calculated_mol_wt=222396
     Region          <2..49
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          58..438
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          64..104
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          110..148
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          153..201
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          203..233
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          240..273
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          286..321
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          328..352
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          369..401
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          411..451
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          521..564
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          <672..715
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          725..1063
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Site            order(726,744,750,756..757,769..770,789,793,801..802,
                     814..815,834,839,843..844,862,879,884,890,901..902,918,
                     922,928..929,995..996,1014,1019,1025..1026,1038..1039,
                     1057,1061)
                     /site_type="active"
                     /note="structural tetrad [active]"
                     /db_xref="CDD:238121"
     Region          730..769
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          776..814
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          819..861
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          895..1266
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          907..939
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          941..994
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1002..1037
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1043..1078
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1085..1122
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1193..1235
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1339..1410
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          1428..1807
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          1480..1522
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1543..1600
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1605..1690
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1689..1945
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          1697..1735
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1780..1813
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1826..1884
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1892..1926
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..1994
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /coded_by="XM_011536532.4:451..6435"
                     /db_xref="GeneID:161436"
                     /db_xref="HGNC:HGNC:18197"
                     /db_xref="MIM:618119"
ORIGIN      
        1 maarsapsch lrlewvygyr ghqcrnnlyy taakeivyfv agvgvvyspr ehrqkfyrgh
       61 sddiislalh pervlvatgq vgkepyiciw dsytvqtisv lkdvhthgia clafdldgqr
      121 lvsvgldskn avcvwdwkrg kmlsmapght drifdiswdl yqpnklvscg vkhikfwslc
      181 gnaltpkrgv fgktgdlqti lclacardel tysgalngdi yvwkginlir tiqgahaagi
      241 fsmnaceegf atggrdgcir lwdltfkpit vidlretdqg ykglsvrsvc wrgdhilvgt
      301 qdseifeivv qernkpflim qghcegelwa lavhptkpla vtgsddrsvr iwslvdhali
      361 arcnmeepir caavnadgih lalgmkdgsf tvlrvrdmte vvhikdrkea ihelkyspdg
      421 tylavgcnds svdiygvaqr ykkvgeclgs lsfithldws sdsrylqtnd gngkrlfyrm
      481 pggkevtste eikgvhwasw tcvsglevng iwpkysdind insvdgnyig qvlvtaddyg
      541 iiklfrypcl rkgakfrkyi ghsahvtnvr wshdyqwvis iggadhsvfq wkfiperklk
      601 davhiapqes ladshsdesd sdlsdvpeld seieqetqlt yrrqvykedl pqlkeqckek
      661 qksatskrre rapgnsirlh fvhgyrgydc rsnlfytqig eivyhvaavg viynrqqntq
      721 rfylghdddi lcltihplkd yvatgqvgrd psihiwdtet ikplsilkgh hqygvsavdf
      781 sadgkrlasv giddshtvvl wdwkkgekls iargskdkif vvkmnpyvpd klitagikhm
      841 kfwrkagggl igrkgyigtl gkndtmmcav ygwteemafs gtstgdvciw rdiflvktvk
      901 ahdgpvfsmh alekgfvtgg kdgivalwdd sferclktya ikraalapgs kglllednps
      961 iraislghgh ilvgtkngei levdksgpit llvqghmege vwglathpyl picatvsddk
     1021 tlriwdlsps hcmlavrklk kggrcccfsp dgkalavgln dgsflmanad tledlvsfhh
     1081 rkdmisdirf spgsgkylav ashdsfidiy nvmsskrvgi ckgatsyith idwdirgkll
     1141 qvntgakeql ffeaprgkkq tipsveveki awaswtsvlg lccegiwpvi gevtdvtasc
     1201 ltsdkmvlat gddlgfvklf ryptkgkfgk fkryvahsth vtnvrwtydd smlvtlggtd
     1261 mslmvwtnem egyrekrpcd seesdidsee dggydsdvtr eneisytira lstnirpmlg
     1321 ikphlqqkep siderqgvvr gsrppvsrap pqpeklqtnn vgkkkrpied lvlelifgyr
     1381 grdcrnnvhy lndgddiiyh tasvgilhnv atgsqsfyqe hnddilcltv nqhpkfiniv
     1441 atgqvgdsad msatapsihi wdamnkqtls ilrcyhskgv csvsfsatgk lllsvgldpe
     1501 htitiwrwqe gakiasragh nqrifvaefr pdsdtqfvsv gvkhvkfwtl agrallskkg
     1561 llstledarm qtmlaiafgt isgdvcvwkd hilcrivara hngpvfamyt tlrdglivtg
     1621 gkerpskegg avklwdqelr rcrafrletg qatdcvrsvc rgkgkilvgt rnaeiievge
     1681 knaacnilvn ghvdgpiwgl athpsrdffl saaedgtvrl wdiadkkmln kvnlghaart
     1741 vcyspegdmv aigmkngefi illvsslkiw gkkrdrrcai hdirfspdsr ylavgssens
     1801 vdfydltlgp tlnrisyckd ipsfviqmdf sadssylqvs sgcykrhvye vpsgkhlmdh
     1861 aaidritwat wtsilgdevl giwsrhaeka dvncacvshs gislvtgddf gmvklfdfpc
     1921 pekfvslcfv yyyqftpnfd vlssalfpiy lkcfvliskf fpklsksiyf eikairnkss
     1981 pssntifgti lqkl
//
LOCUS       XP_016876553            1964 aa            linear   PRI 05-AUG-2025
DEFINITION  echinoderm microtubule-associated protein-like 5 isoform X7 [Homo
            sapiens].
ACCESSION   XP_016876553
VERSION     XP_016876553.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021064.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1964
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1964
                     /product="echinoderm microtubule-associated protein-like 5
                     isoform X7"
                     /calculated_mol_wt=219271
     Region          <2..49
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          58..438
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          64..104
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          110..148
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          153..201
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          203..233
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          240..273
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          286..321
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          328..352
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          369..401
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          411..451
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          521..564
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          <672..715
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          720..1074
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          731..769
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          775..814
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          820..863
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          868..907
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          915..956
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          963..997
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1005..1031
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1047..1072
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1091..1125
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1155..1197
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1301..1372
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          1388..1437
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1390..1777
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          1442..1480
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1486..1529
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1535..1570
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1575..1660
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1659..1915
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          1667..1705
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1750..1783
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1796..1854
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1862..1896
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..1964
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /coded_by="XM_017021064.3:451..6345"
                     /db_xref="GeneID:161436"
                     /db_xref="HGNC:HGNC:18197"
                     /db_xref="MIM:618119"
ORIGIN      
        1 maarsapsch lrlewvygyr ghqcrnnlyy taakeivyfv agvgvvyspr ehrqkfyrgh
       61 sddiislalh pervlvatgq vgkepyiciw dsytvqtisv lkdvhthgia clafdldgqr
      121 lvsvgldskn avcvwdwkrg kmlsmapght drifdiswdl yqpnklvscg vkhikfwslc
      181 gnaltpkrgv fgktgdlqti lclacardel tysgalngdi yvwkginlir tiqgahaagi
      241 fsmnaceegf atggrdgcir lwdltfkpit vidlretdqg ykglsvrsvc wrgdhilvgt
      301 qdseifeivv qernkpflim qghcegelwa lavhptkpla vtgsddrsvr iwslvdhali
      361 arcnmeepir caavnadgih lalgmkdgsf tvlrvrdmte vvhikdrkea ihelkyspdg
      421 tylavgcnds svdiygvaqr ykkvgeclgs lsfithldws sdsrylqtnd gngkrlfyrm
      481 pggkevtste eikgvhwasw tcvsglevng iwpkysdind insvdgnyig qvlvtaddyg
      541 iiklfrypcl rkgakfrkyi ghsahvtnvr wshdyqwvis iggadhsvfq wkfiperklk
      601 davhiapqes ladshsdesd sdlsdvpeld seieqetqlt yrrqvykedl pqlkeqckek
      661 qksatskrre rapgnsirlh fvhgyrgydc rsnlfytqig eivyhvaavg viynrqqntq
      721 rfylghdddi lcltihplkd yvatgqvgrd psihiwdtet ikplsilkgh hqygvsavdf
      781 sadgkrlasv giddshtvvl wdwkkgekls iargskdkif vvkmnpyvpd klitagikhm
      841 kfwrkagdvc iwrdiflvkt vkahdgpvfs mhalekgfvt ggkdgivalw ddsferclkt
      901 yaikraalap gskgllledn psiraislgh ghilvgtkng eilevdksgp itllvqghme
      961 gevwglathp ylpicatvsd dktlriwdls pshcmlavrk lkkggrcccf spdgkalavg
     1021 lndgsflman adtledlvsf hhrkdmisdi rfspgsgkyl avashdsfid iynvmsskrv
     1081 gickgatsyi thidwdirgk llqvntgake qlffeaprgk kqtipsveve kiawaswtsv
     1141 lglccegiwp vigevtdvta scltsdkmvl atgddlgfvk lfryptkgkf gkfkryvahs
     1201 thvtnvrwty ddsmlvtlgg tdmslmvwtn emegyrekrp cdseesdids eedggydsdv
     1261 treneisyti ralstnirpm lgikphlqqk epsiderqgv vrgsrppvsr appqpeklqt
     1321 nnvgkkkrpi edlvlelifg yrgrdcrnnv hylndgddii yhtasvgilh nvatgsqsfy
     1381 qehnddilcl tvnqhpkfin ivatgqvgds admsatapsi hiwdamnkqt lsilrcyhsk
     1441 gvcsvsfsat gklllsvgld pehtitiwrw qegakiasra ghnqrifvae frpdsdtqfv
     1501 svgvkhvkfw tlagrallsk kgllstleda rmqtmlaiaf gannltftgt isgdvcvwkd
     1561 hilcrivara hngpvfamyt tlrdglivtg gkerpskegg avklwdqelr rcrafrletg
     1621 qatdcvrsvc rgkgkilvgt rnaeiievge knaacnilvn ghvdgpiwgl athpsrdffl
     1681 saaedgtvrl wdiadkkmln kvnlghaart vcyspegdmv aigmkngefi illvsslkiw
     1741 gkkrdrrcai hdirfspdsr ylavgssens vdfydltlgp tlnrisyckd ipsfviqmdf
     1801 sadssylqvs sgcykrhvye vpsgkhlmdh aaidritwat wtsilgdevl giwsrhaeka
     1861 dvncacvshs gislvtgddf gmvklfdfpc pekfvslcfv yyyqftpnfd vlssalfpiy
     1921 lkcfvliskf fpklsksiyf eikairnkss pssntifgti lqkl
//
LOCUS       XP_016876554            1962 aa            linear   PRI 05-AUG-2025
DEFINITION  echinoderm microtubule-associated protein-like 5 isoform X8 [Homo
            sapiens].
ACCESSION   XP_016876554
VERSION     XP_016876554.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021065.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1962
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1962
                     /product="echinoderm microtubule-associated protein-like 5
                     isoform X8"
                     /calculated_mol_wt=218633
     Region          <2..49
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          58..438
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          64..104
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          110..148
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          153..201
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          203..233
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          240..273
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          286..321
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          328..352
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          369..401
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          411..451
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          521..564
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          <672..715
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          725..1063
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Site            order(726,744,750,756..757,769..770,789,793,801..802,
                     814..815,834,839,843..844,862,879,884,890,901..902,918,
                     922,928..929,995..996,1014,1019,1025..1026,1038..1039,
                     1057,1061)
                     /site_type="active"
                     /note="structural tetrad [active]"
                     /db_xref="CDD:238121"
     Region          730..769
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          776..814
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          819..861
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          895..1266
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          907..939
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          941..994
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1002..1037
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1043..1078
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1085..1122
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1193..1235
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          <1355..1402
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          1418..1460
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          <1437..1800
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          1465..1503
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1509..1552
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1558..1593
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1598..1683
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1682..1955
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          1690..1728
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1773..1806
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1819..1877
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1885..1924
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..1962
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /coded_by="XM_017021065.3:451..6339"
                     /db_xref="GeneID:161436"
                     /db_xref="HGNC:HGNC:18197"
                     /db_xref="MIM:618119"
ORIGIN      
        1 maarsapsch lrlewvygyr ghqcrnnlyy taakeivyfv agvgvvyspr ehrqkfyrgh
       61 sddiislalh pervlvatgq vgkepyiciw dsytvqtisv lkdvhthgia clafdldgqr
      121 lvsvgldskn avcvwdwkrg kmlsmapght drifdiswdl yqpnklvscg vkhikfwslc
      181 gnaltpkrgv fgktgdlqti lclacardel tysgalngdi yvwkginlir tiqgahaagi
      241 fsmnaceegf atggrdgcir lwdltfkpit vidlretdqg ykglsvrsvc wrgdhilvgt
      301 qdseifeivv qernkpflim qghcegelwa lavhptkpla vtgsddrsvr iwslvdhali
      361 arcnmeepir caavnadgih lalgmkdgsf tvlrvrdmte vvhikdrkea ihelkyspdg
      421 tylavgcnds svdiygvaqr ykkvgeclgs lsfithldws sdsrylqtnd gngkrlfyrm
      481 pggkevtste eikgvhwasw tcvsglevng iwpkysdind insvdgnyig qvlvtaddyg
      541 iiklfrypcl rkgakfrkyi ghsahvtnvr wshdyqwvis iggadhsvfq wkfiperklk
      601 davhiapqes ladshsdesd sdlsdvpeld seieqetqlt yrrqvykedl pqlkeqckek
      661 qksatskrre rapgnsirlh fvhgyrgydc rsnlfytqig eivyhvaavg viynrqqntq
      721 rfylghdddi lcltihplkd yvatgqvgrd psihiwdtet ikplsilkgh hqygvsavdf
      781 sadgkrlasv giddshtvvl wdwkkgekls iargskdkif vvkmnpyvpd klitagikhm
      841 kfwrkagggl igrkgyigtl gkndtmmcav ygwteemafs gtstgdvciw rdiflvktvk
      901 ahdgpvfsmh alekgfvtgg kdgivalwdd sferclktya ikraalapgs kglllednps
      961 iraislghgh ilvgtkngei levdksgpit llvqghmege vwglathpyl picatvsddk
     1021 tlriwdlsps hcmlavrklk kggrcccfsp dgkalavgln dgsflmanad tledlvsfhh
     1081 rkdmisdirf spgsgkylav ashdsfidiy nvmsskrvgi ckgatsyith idwdirgkll
     1141 qvntgakeql ffeaprgkkq tipsveveki awaswtsvlg lccegiwpvi gevtdvtasc
     1201 ltsdkmvlat gddlgfvklf ryptkgkfgk fkryvahsth vtnvrwtydd smlvtlggtd
     1261 mslmvwtnem egyrekrpcd seesdidsee dggydsdvtr eneisytira lstnirpmlg
     1321 ikphlqqkep siderppvsr appqpeklqt nnvgkkkrpi edlvlelifg yrgrdcrnnv
     1381 hylndgddii yhtasvgilh nvatgsqsfy qehnddilcl tvnqhpkfin ivatgqvata
     1441 psihiwdamn kqtlsilrcy hskgvcsvsf satgklllsv gldpehtiti wrwqegakia
     1501 sraghnqrif vaefrpdsdt qfvsvgvkhv kfwtlagral lskkgllstl edarmqtmla
     1561 iafgannltf tgtisgdvcv wkdhilcriv arahngpvfa myttlrdgli vtggkerpsk
     1621 eggavklwdq elrrcrafrl etgqatdcvr svcrgkgkil vgtrnaeiie vgeknaacni
     1681 lvnghvdgpi wglathpsrd fflsaaedgt vrlwdiadkk mlnkvnlgha artvcyspeg
     1741 dmvaigmkng efiillvssl kiwgkkrdrr caihdirfsp dsrylavgss ensvdfydlt
     1801 lgptlnrisy ckdipsfviq mdfsadssyl qvssgcykrh vyevpsgkhl mdhaaidrit
     1861 watwtsilgd evlgiwsrha ekadvncacv shsgislvtg ddfgmvklfd fpcpekfakh
     1921 krflghsphv tnirftsgdr hvvsaggddc slfvwkcvht ph
//
LOCUS       XP_047287012            1961 aa            linear   PRI 05-AUG-2025
DEFINITION  echinoderm microtubule-associated protein-like 5 isoform X9 [Homo
            sapiens].
ACCESSION   XP_047287012
VERSION     XP_047287012.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431056.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1961
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1961
                     /product="echinoderm microtubule-associated protein-like 5
                     isoform X9"
                     /calculated_mol_wt=218478
     Region          <2..49
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          58..438
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          64..104
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          110..148
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          153..201
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          203..233
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          240..273
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          286..321
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          328..352
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          369..401
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          411..451
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          521..564
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          <672..715
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          725..1063
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Site            order(726,744,750,756..757,769..770,789,793,801..802,
                     814..815,834,839,843..844,862,879,884,890,901..902,918,
                     922,928..929,995..996,1014,1019,1025..1026,1038..1039,
                     1057,1061)
                     /site_type="active"
                     /note="structural tetrad [active]"
                     /db_xref="CDD:238121"
     Region          730..769
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          776..814
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          819..861
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          895..1266
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          907..939
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          941..994
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1002..1037
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1043..1078
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1085..1122
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1193..1235
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          <1355..1402
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          1420..1799
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          1472..1514
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1535..1592
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1597..1682
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1681..1954
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          1690..1725
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1732..1770
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1773..1811
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1817..1851
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1884..1923
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..1961
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /coded_by="XM_047431056.1:451..6336"
                     /db_xref="GeneID:161436"
                     /db_xref="HGNC:HGNC:18197"
                     /db_xref="MIM:618119"
ORIGIN      
        1 maarsapsch lrlewvygyr ghqcrnnlyy taakeivyfv agvgvvyspr ehrqkfyrgh
       61 sddiislalh pervlvatgq vgkepyiciw dsytvqtisv lkdvhthgia clafdldgqr
      121 lvsvgldskn avcvwdwkrg kmlsmapght drifdiswdl yqpnklvscg vkhikfwslc
      181 gnaltpkrgv fgktgdlqti lclacardel tysgalngdi yvwkginlir tiqgahaagi
      241 fsmnaceegf atggrdgcir lwdltfkpit vidlretdqg ykglsvrsvc wrgdhilvgt
      301 qdseifeivv qernkpflim qghcegelwa lavhptkpla vtgsddrsvr iwslvdhali
      361 arcnmeepir caavnadgih lalgmkdgsf tvlrvrdmte vvhikdrkea ihelkyspdg
      421 tylavgcnds svdiygvaqr ykkvgeclgs lsfithldws sdsrylqtnd gngkrlfyrm
      481 pggkevtste eikgvhwasw tcvsglevng iwpkysdind insvdgnyig qvlvtaddyg
      541 iiklfrypcl rkgakfrkyi ghsahvtnvr wshdyqwvis iggadhsvfq wkfiperklk
      601 davhiapqes ladshsdesd sdlsdvpeld seieqetqlt yrrqvykedl pqlkeqckek
      661 qksatskrre rapgnsirlh fvhgyrgydc rsnlfytqig eivyhvaavg viynrqqntq
      721 rfylghdddi lcltihplkd yvatgqvgrd psihiwdtet ikplsilkgh hqygvsavdf
      781 sadgkrlasv giddshtvvl wdwkkgekls iargskdkif vvkmnpyvpd klitagikhm
      841 kfwrkagggl igrkgyigtl gkndtmmcav ygwteemafs gtstgdvciw rdiflvktvk
      901 ahdgpvfsmh alekgfvtgg kdgivalwdd sferclktya ikraalapgs kglllednps
      961 iraislghgh ilvgtkngei levdksgpit llvqghmege vwglathpyl picatvsddk
     1021 tlriwdlsps hcmlavrklk kggrcccfsp dgkalavgln dgsflmanad tledlvsfhh
     1081 rkdmisdirf spgsgkylav ashdsfidiy nvmsskrvgi ckgatsyith idwdirgkll
     1141 qvntgakeql ffeaprgkkq tipsveveki awaswtsvlg lccegiwpvi gevtdvtasc
     1201 ltsdkmvlat gddlgfvklf ryptkgkfgk fkryvahsth vtnvrwtydd smlvtlggtd
     1261 mslmvwtnem egyrekrpcd seesdidsee dggydsdvtr eneisytira lstnirpmlg
     1321 ikphlqqkep siderppvsr appqpeklqt nnvgkkkrpi edlvlelifg yrgrdcrnnv
     1381 hylndgddii yhtasvgilh nvatgsqsfy qehnddilcl tvnqhpkfin ivatgqvgds
     1441 admsatapsi hiwdamnkqt lsilrcyhsk gvcsvsfsat gklllsvgld pehtitiwrw
     1501 qegakiasra ghnqrifvae frpdsdtqfv svgvkhvkfw tlagrallsk kgllstleda
     1561 rmqtmlaiaf gtisgdvcvw kdhilcriva rahngpvfam yttlrdgliv tggkerpske
     1621 ggavklwdqe lrrcrafrle tgqatdcvrs vcrgkgkilv gtrnaeiiev geknaacnil
     1681 vnghvdgpiw glathpsrdf flsaaedgtv rlwdiadkkm lnkvnlghaa rtvcyspegd
     1741 mvaigmknge fiillvsslk iwgkkrdrrc aihdirfspd srylavgsse nsvdfydltl
     1801 gptlnrisyc kdipsfviqm dfsadssylq vssgcykrhv yevpsgkhlm dhaaidritw
     1861 atwtsilgde vlgiwsrhae kadvncacvs hsgislvtgd dfgmvklfdf pcpekfakhk
     1921 rflghsphvt nirftsgdrh vvsaggddcs lfvwkcvhtp h
//
LOCUS       XP_011534835            1956 aa            linear   PRI 05-AUG-2025
DEFINITION  echinoderm microtubule-associated protein-like 5 isoform X10 [Homo
            sapiens].
ACCESSION   XP_011534835
VERSION     XP_011534835.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536533.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1956
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1956
                     /product="echinoderm microtubule-associated protein-like 5
                     isoform X10"
                     /calculated_mol_wt=218431
     Region          <2..49
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          58..438
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          64..104
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          110..148
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          153..201
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          203..233
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          240..273
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          286..321
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          328..352
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          369..401
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          411..451
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          521..564
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          <672..715
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          720..1074
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          731..769
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          775..814
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          820..863
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          868..907
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          915..956
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          963..997
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1005..1031
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1047..1072
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1091..1125
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1155..1197
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          <1317..1364
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          1380..1429
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1382..1769
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          1434..1472
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1478..1521
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1527..1562
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1567..1652
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1651..1907
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          1659..1697
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1742..1775
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1788..1846
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1854..1888
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..1956
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /coded_by="XM_011536533.4:451..6321"
                     /db_xref="GeneID:161436"
                     /db_xref="HGNC:HGNC:18197"
                     /db_xref="MIM:618119"
ORIGIN      
        1 maarsapsch lrlewvygyr ghqcrnnlyy taakeivyfv agvgvvyspr ehrqkfyrgh
       61 sddiislalh pervlvatgq vgkepyiciw dsytvqtisv lkdvhthgia clafdldgqr
      121 lvsvgldskn avcvwdwkrg kmlsmapght drifdiswdl yqpnklvscg vkhikfwslc
      181 gnaltpkrgv fgktgdlqti lclacardel tysgalngdi yvwkginlir tiqgahaagi
      241 fsmnaceegf atggrdgcir lwdltfkpit vidlretdqg ykglsvrsvc wrgdhilvgt
      301 qdseifeivv qernkpflim qghcegelwa lavhptkpla vtgsddrsvr iwslvdhali
      361 arcnmeepir caavnadgih lalgmkdgsf tvlrvrdmte vvhikdrkea ihelkyspdg
      421 tylavgcnds svdiygvaqr ykkvgeclgs lsfithldws sdsrylqtnd gngkrlfyrm
      481 pggkevtste eikgvhwasw tcvsglevng iwpkysdind insvdgnyig qvlvtaddyg
      541 iiklfrypcl rkgakfrkyi ghsahvtnvr wshdyqwvis iggadhsvfq wkfiperklk
      601 davhiapqes ladshsdesd sdlsdvpeld seieqetqlt yrrqvykedl pqlkeqckek
      661 qksatskrre rapgnsirlh fvhgyrgydc rsnlfytqig eivyhvaavg viynrqqntq
      721 rfylghdddi lcltihplkd yvatgqvgrd psihiwdtet ikplsilkgh hqygvsavdf
      781 sadgkrlasv giddshtvvl wdwkkgekls iargskdkif vvkmnpyvpd klitagikhm
      841 kfwrkagdvc iwrdiflvkt vkahdgpvfs mhalekgfvt ggkdgivalw ddsferclkt
      901 yaikraalap gskgllledn psiraislgh ghilvgtkng eilevdksgp itllvqghme
      961 gevwglathp ylpicatvsd dktlriwdls pshcmlavrk lkkggrcccf spdgkalavg
     1021 lndgsflman adtledlvsf hhrkdmisdi rfspgsgkyl avashdsfid iynvmsskrv
     1081 gickgatsyi thidwdirgk llqvntgake qlffeaprgk kqtipsveve kiawaswtsv
     1141 lglccegiwp vigevtdvta scltsdkmvl atgddlgfvk lfryptkgkf gkfkryvahs
     1201 thvtnvrwty ddsmlvtlgg tdmslmvwtn emegyrekrp cdseesdids eedggydsdv
     1261 treneisyti ralstnirpm lgikphlqqk epsiderppv srappqpekl qtnnvgkkkr
     1321 piedlvleli fgyrgrdcrn nvhylndgdd iiyhtasvgi lhnvatgsqs fyqehnddil
     1381 cltvnqhpkf inivatgqvg dsadmsatap sihiwdamnk qtlsilrcyh skgvcsvsfs
     1441 atgklllsvg ldpehtitiw rwqegakias raghnqrifv aefrpdsdtq fvsvgvkhvk
     1501 fwtlagrall skkgllstle darmqtmlai afgannltft gtisgdvcvw kdhilcriva
     1561 rahngpvfam yttlrdgliv tggkerpske ggavklwdqe lrrcrafrle tgqatdcvrs
     1621 vcrgkgkilv gtrnaeiiev geknaacnil vnghvdgpiw glathpsrdf flsaaedgtv
     1681 rlwdiadkkm lnkvnlghaa rtvcyspegd mvaigmknge fiillvsslk iwgkkrdrrc
     1741 aihdirfspd srylavgsse nsvdfydltl gptlnrisyc kdipsfviqm dfsadssylq
     1801 vssgcykrhv yevpsgkhlm dhaaidritw atwtsilgde vlgiwsrhae kadvncacvs
     1861 hsgislvtgd dfgmvklfdf pcpekfvslc fvyyyqftpn fdvlssalfp iylkcfvlis
     1921 kffpklsksi yfeikairnk sspssntifg tilqkl
//
LOCUS       XP_016876555            1946 aa            linear   PRI 05-AUG-2025
DEFINITION  echinoderm microtubule-associated protein-like 5 isoform X11 [Homo
            sapiens].
ACCESSION   XP_016876555
VERSION     XP_016876555.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021066.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1946
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1946
                     /product="echinoderm microtubule-associated protein-like 5
                     isoform X11"
                     /calculated_mol_wt=216718
     Region          <2..49
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          58..438
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          64..104
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          110..148
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          153..201
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          203..233
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          240..273
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          286..321
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          328..352
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          369..401
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          411..451
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          521..547
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          <616..659
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          669..1007
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Site            order(670,688,694,700..701,713..714,733,737,745..746,
                     758..759,778,783,787..788,806,823,828,834,845..846,862,
                     866,872..873,939..940,958,963,969..970,982..983,1001,1005)
                     /site_type="active"
                     /note="structural tetrad [active]"
                     /db_xref="CDD:238121"
     Region          674..713
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          720..758
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          763..805
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          839..1210
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          851..883
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          885..938
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          946..981
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          987..1022
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1029..1066
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1137..1179
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1283..1354
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          1370..1419
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1372..1759
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          1424..1462
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1468..1511
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1517..1552
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1557..1642
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1641..1897
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          1649..1687
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1732..1765
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1778..1836
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1844..1878
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..1946
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /coded_by="XM_017021066.3:451..6291"
                     /db_xref="GeneID:161436"
                     /db_xref="HGNC:HGNC:18197"
                     /db_xref="MIM:618119"
ORIGIN      
        1 maarsapsch lrlewvygyr ghqcrnnlyy taakeivyfv agvgvvyspr ehrqkfyrgh
       61 sddiislalh pervlvatgq vgkepyiciw dsytvqtisv lkdvhthgia clafdldgqr
      121 lvsvgldskn avcvwdwkrg kmlsmapght drifdiswdl yqpnklvscg vkhikfwslc
      181 gnaltpkrgv fgktgdlqti lclacardel tysgalngdi yvwkginlir tiqgahaagi
      241 fsmnaceegf atggrdgcir lwdltfkpit vidlretdqg ykglsvrsvc wrgdhilvgt
      301 qdseifeivv qernkpflim qghcegelwa lavhptkpla vtgsddrsvr iwslvdhali
      361 arcnmeepir caavnadgih lalgmkdgsf tvlrvrdmte vvhikdrkea ihelkyspdg
      421 tylavgcnds svdiygvaqr ykkvgeclgs lsfithldws sdsrylqtnd gngkrlfyrm
      481 pggkevtste eikgvhwasw tcvsglevng iwpkysdind insvdgnyig qvlvtaddyg
      541 iiklfrypcl rkesladshs desdsdlsdv peldseieqe tqltyrrqvy kedlpqlkeq
      601 ckekqksats krrerapgns irlhfvhgyr gydcrsnlfy tqigeivyhv aavgviynrq
      661 qntqrfylgh dddilcltih plkdyvatgq vgrdpsihiw dtetikplsi lkghhqygvs
      721 avdfsadgkr lasvgiddsh tvvlwdwkkg eklsiargsk dkifvvkmnp yvpdklitag
      781 ikhmkfwrka gggligrkgy igtlgkndtm mcavygwtee mafsgtstgd vciwrdiflv
      841 ktvkahdgpv fsmhalekgf vtggkdgiva lwddsfercl ktyaikraal apgskgllle
      901 dnpsiraisl ghghilvgtk ngeilevdks gpitllvqgh megevwglat hpylpicatv
      961 sddktlriwd lspshcmlav rklkkggrcc cfspdgkala vglndgsflm anadtledlv
     1021 sfhhrkdmis dirfspgsgk ylavashdsf idiynvmssk rvgickgats yithidwdir
     1081 gkllqvntga keqlffeapr gkkqtipsve vekiawaswt svlglccegi wpvigevtdv
     1141 tascltsdkm vlatgddlgf vklfryptkg kfgkfkryva hsthvtnvrw tyddsmlvtl
     1201 ggtdmslmvw tnemegyrek rpcdseesdi dseedggyds dvtreneisy tiralstnir
     1261 pmlgikphlq qkepsiderq gvvrgsrppv srappqpekl qtnnvgkkkr piedlvleli
     1321 fgyrgrdcrn nvhylndgdd iiyhtasvgi lhnvatgsqs fyqehnddil cltvnqhpkf
     1381 inivatgqvg dsadmsatap sihiwdamnk qtlsilrcyh skgvcsvsfs atgklllsvg
     1441 ldpehtitiw rwqegakias raghnqrifv aefrpdsdtq fvsvgvkhvk fwtlagrall
     1501 skkgllstle darmqtmlai afgannltft gtisgdvcvw kdhilcriva rahngpvfam
     1561 yttlrdgliv tggkerpske ggavklwdqe lrrcrafrle tgqatdcvrs vcrgkgkilv
     1621 gtrnaeiiev geknaacnil vnghvdgpiw glathpsrdf flsaaedgtv rlwdiadkkm
     1681 lnkvnlghaa rtvcyspegd mvaigmknge fiillvsslk iwgkkrdrrc aihdirfspd
     1741 srylavgsse nsvdfydltl gptlnrisyc kdipsfviqm dfsadssylq vssgcykrhv
     1801 yevpsgkhlm dhaaidritw atwtsilgde vlgiwsrhae kadvncacvs hsgislvtgd
     1861 dfgmvklfdf pcpekfvslc fvyyyqftpn fdvlssalfp iylkcfvlis kffpklsksi
     1921 yfeikairnk sspssntifg tilqkl
//
LOCUS       XP_016876556            1945 aa            linear   PRI 05-AUG-2025
DEFINITION  echinoderm microtubule-associated protein-like 5 isoform X12 [Homo
            sapiens].
ACCESSION   XP_016876556
VERSION     XP_016876556.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021067.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1945
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1945
                     /product="echinoderm microtubule-associated protein-like 5
                     isoform X12"
                     /calculated_mol_wt=216471
     Region          <8..381
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          9..47
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          53..91
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          96..144
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          146..176
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          183..216
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          229..264
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          271..295
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          312..344
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          354..394
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          464..507
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          <615..658
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          668..1006
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Site            order(669,687,693,699..700,712..713,732,736,744..745,
                     757..758,777,782,786..787,805,822,827,833,844..845,861,
                     865,871..872,938..939,957,962,968..969,981..982,1000,1004)
                     /site_type="active"
                     /note="structural tetrad [active]"
                     /db_xref="CDD:238121"
     Region          673..712
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          719..757
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          762..804
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          838..1209
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          850..882
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          884..937
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          945..980
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          986..1021
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1028..1065
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1136..1178
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1282..1353
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          1369..1418
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1371..1758
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          1423..1461
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1467..1510
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1516..1551
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1556..1641
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1640..1896
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          1648..1686
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1731..1764
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1777..1835
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1843..1877
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..1945
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /coded_by="XM_017021067.3:543..6380"
                     /db_xref="GeneID:161436"
                     /db_xref="HGNC:HGNC:18197"
                     /db_xref="MIM:618119"
ORIGIN      
        1 mctpegnlsl alhpervlva tgqvgkepyi ciwdsytvqt isvlkdvhth giaclafdld
       61 gqrlvsvgld sknavcvwdw krgkmlsmap ghtdrifdis wdlyqpnklv scgvkhikfw
      121 slcgnaltpk rgvfgktgdl qtilclacar deltysgaln gdiyvwkgin lirtiqgaha
      181 agifsmnace egfatggrdg cirlwdltfk pitvidlret dqgykglsvr svcwrgdhil
      241 vgtqdseife ivvqernkpf limqghcege lwalavhptk plavtgsddr svriwslvdh
      301 aliarcnmee pircaavnad gihlalgmkd gsftvlrvrd mtevvhikdr keaihelkys
      361 pdgtylavgc ndssvdiygv aqrykkvgec lgslsfithl dwssdsrylq tndgngkrlf
      421 yrmpggkevt steeikgvhw aswtcvsgle vngiwpkysd indinsvdgn yigqvlvtad
      481 dygiiklfry pclrkgakfr kyighsahvt nvrwshdyqw visiggadhs vfqwkfiper
      541 klkdavhiap qesladshsd esdsdlsdvp eldseieqet qltyrrqvyk edlpqlkeqc
      601 kekqksatsk rrerapgnsi rlhfvhgyrg ydcrsnlfyt qigeivyhva avgviynrqq
      661 ntqrfylghd ddilcltihp lkdyvatgqv grdpsihiwd tetikplsil kghhqygvsa
      721 vdfsadgkrl asvgiddsht vvlwdwkkge klsiargskd kifvvkmnpy vpdklitagi
      781 khmkfwrkag ggligrkgyi gtlgkndtmm cavygwteem afsgtstgdv ciwrdiflvk
      841 tvkahdgpvf smhalekgfv tggkdgival wddsferclk tyaikraala pgskgllled
      901 npsiraislg hghilvgtkn geilevdksg pitllvqghm egevwglath pylpicatvs
      961 ddktlriwdl spshcmlavr klkkggrccc fspdgkalav glndgsflma nadtledlvs
     1021 fhhrkdmisd irfspgsgky lavashdsfi diynvmsskr vgickgatsy ithidwdirg
     1081 kllqvntgak eqlffeaprg kkqtipsvev ekiawaswts vlglccegiw pvigevtdvt
     1141 ascltsdkmv latgddlgfv klfryptkgk fgkfkryvah sthvtnvrwt yddsmlvtlg
     1201 gtdmslmvwt nemegyrekr pcdseesdid seedggydsd vtreneisyt iralstnirp
     1261 mlgikphlqq kepsiderqg vvrgsrppvs rappqpeklq tnnvgkkkrp iedlvlelif
     1321 gyrgrdcrnn vhylndgddi iyhtasvgil hnvatgsqsf yqehnddilc ltvnqhpkfi
     1381 nivatgqvgd sadmsataps ihiwdamnkq tlsilrcyhs kgvcsvsfsa tgklllsvgl
     1441 dpehtitiwr wqegakiasr aghnqrifva efrpdsdtqf vsvgvkhvkf wtlagralls
     1501 kkgllstled armqtmlaia fgannltftg tisgdvcvwk dhilcrivar ahngpvfamy
     1561 ttlrdglivt ggkerpskeg gavklwdqel rrcrafrlet gqatdcvrsv crgkgkilvg
     1621 trnaeiievg eknaacnilv nghvdgpiwg lathpsrdff lsaaedgtvr lwdiadkkml
     1681 nkvnlghaar tvcyspegdm vaigmkngef iillvsslki wgkkrdrrca ihdirfspds
     1741 rylavgssen svdfydltlg ptlnrisyck dipsfviqmd fsadssylqv ssgcykrhvy
     1801 evpsgkhlmd haaidritwa twtsilgdev lgiwsrhaek advncacvsh sgislvtgdd
     1861 fgmvklfdfp cpekfvslcf vyyyqftpnf dvlssalfpi ylkcfvlisk ffpklsksiy
     1921 feikairnks spssntifgt ilqkl
//
LOCUS       XP_016876557            1944 aa            linear   PRI 05-AUG-2025
DEFINITION  echinoderm microtubule-associated protein-like 5 isoform X13 [Homo
            sapiens].
ACCESSION   XP_016876557
VERSION     XP_016876557.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021068.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1944
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1944
                     /product="echinoderm microtubule-associated protein-like 5
                     isoform X13"
                     /calculated_mol_wt=216734
     Region          <2..49
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          58..438
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          64..104
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          110..148
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          153..201
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          203..233
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          240..273
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          286..321
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          328..352
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          369..401
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          411..451
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          521..564
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          <672..715
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          725..1063
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Site            order(726,744,750,756..757,769..770,789,793,801..802,
                     814..815,834,839,843..844,862,879,884,890,901..902,918,
                     922,928..929,995..996,1014,1019,1025..1026,1038..1039,
                     1057,1061)
                     /site_type="active"
                     /note="structural tetrad [active]"
                     /db_xref="CDD:238121"
     Region          730..769
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          776..814
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          819..861
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          895..1266
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          907..939
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          941..994
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1002..1037
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1043..1078
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1085..1122
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1193..1235
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1339..1410
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          1452..1867
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          1466..1509
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1515..1550
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1555..1640
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1647..1685
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1730..1763
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1776..1834
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1842..1876
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..1944
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /coded_by="XM_017021068.3:451..6285"
                     /db_xref="GeneID:161436"
                     /db_xref="HGNC:HGNC:18197"
                     /db_xref="MIM:618119"
ORIGIN      
        1 maarsapsch lrlewvygyr ghqcrnnlyy taakeivyfv agvgvvyspr ehrqkfyrgh
       61 sddiislalh pervlvatgq vgkepyiciw dsytvqtisv lkdvhthgia clafdldgqr
      121 lvsvgldskn avcvwdwkrg kmlsmapght drifdiswdl yqpnklvscg vkhikfwslc
      181 gnaltpkrgv fgktgdlqti lclacardel tysgalngdi yvwkginlir tiqgahaagi
      241 fsmnaceegf atggrdgcir lwdltfkpit vidlretdqg ykglsvrsvc wrgdhilvgt
      301 qdseifeivv qernkpflim qghcegelwa lavhptkpla vtgsddrsvr iwslvdhali
      361 arcnmeepir caavnadgih lalgmkdgsf tvlrvrdmte vvhikdrkea ihelkyspdg
      421 tylavgcnds svdiygvaqr ykkvgeclgs lsfithldws sdsrylqtnd gngkrlfyrm
      481 pggkevtste eikgvhwasw tcvsglevng iwpkysdind insvdgnyig qvlvtaddyg
      541 iiklfrypcl rkgakfrkyi ghsahvtnvr wshdyqwvis iggadhsvfq wkfiperklk
      601 davhiapqes ladshsdesd sdlsdvpeld seieqetqlt yrrqvykedl pqlkeqckek
      661 qksatskrre rapgnsirlh fvhgyrgydc rsnlfytqig eivyhvaavg viynrqqntq
      721 rfylghdddi lcltihplkd yvatgqvgrd psihiwdtet ikplsilkgh hqygvsavdf
      781 sadgkrlasv giddshtvvl wdwkkgekls iargskdkif vvkmnpyvpd klitagikhm
      841 kfwrkagggl igrkgyigtl gkndtmmcav ygwteemafs gtstgdvciw rdiflvktvk
      901 ahdgpvfsmh alekgfvtgg kdgivalwdd sferclktya ikraalapgs kglllednps
      961 iraislghgh ilvgtkngei levdksgpit llvqghmege vwglathpyl picatvsddk
     1021 tlriwdlsps hcmlavrklk kggrcccfsp dgkalavgln dgsflmanad tledlvsfhh
     1081 rkdmisdirf spgsgkylav ashdsfidiy nvmsskrvgi ckgatsyith idwdirgkll
     1141 qvntgakeql ffeaprgkkq tipsveveki awaswtsvlg lccegiwpvi gevtdvtasc
     1201 ltsdkmvlat gddlgfvklf ryptkgkfgk fkryvahsth vtnvrwtydd smlvtlggtd
     1261 mslmvwtnem egyrekrpcd seesdidsee dggydsdvtr eneisytira lstnirpmlg
     1321 ikphlqqkep siderqgvvr gsrppvsrap pqpeklqtnn vgkkkrpied lvlelifgyr
     1381 grdcrnnvhy lndgddiiyh tasvgilhnv atgsqsfyqe hnddilcltv nqhpkfiniv
     1441 atgqvgdsad msgakiasra ghnqrifvae frpdsdtqfv svgvkhvkfw tlagrallsk
     1501 kgllstleda rmqtmlaiaf gannltftgt isgdvcvwkd hilcrivara hngpvfamyt
     1561 tlrdglivtg gkerpskegg avklwdqelr rcrafrletg qatdcvrsvc rgkgkilvgt
     1621 rnaeiievge knaacnilvn ghvdgpiwgl athpsrdffl saaedgtvrl wdiadkkmln
     1681 kvnlghaart vcyspegdmv aigmkngefi illvsslkiw gkkrdrrcai hdirfspdsr
     1741 ylavgssens vdfydltlgp tlnrisyckd ipsfviqmdf sadssylqvs sgcykrhvye
     1801 vpsgkhlmdh aaidritwat wtsilgdevl giwsrhaeka dvncacvshs gislvtgddf
     1861 gmvklfdfpc pekfvslcfv yyyqftpnfd vlssalfpiy lkcfvliskf fpklsksiyf
     1921 eikairnkss pssntifgti lqkl
//
LOCUS       XP_016876558            1943 aa            linear   PRI 05-AUG-2025
DEFINITION  echinoderm microtubule-associated protein-like 5 isoform X14 [Homo
            sapiens].
ACCESSION   XP_016876558
VERSION     XP_016876558.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021069.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1943
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1943
                     /product="echinoderm microtubule-associated protein-like 5
                     isoform X14"
                     /calculated_mol_wt=216338
     Region          4..379
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          7..45
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          51..89
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          94..142
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          144..174
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          181..214
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          227..262
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          269..293
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          310..342
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          352..392
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          462..505
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          <613..656
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          666..1004
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Site            order(667,685,691,697..698,710..711,730,734,742..743,
                     755..756,775,780,784..785,803,820,825,831,842..843,859,
                     863,869..870,936..937,955,960,966..967,979..980,998,1002)
                     /site_type="active"
                     /note="structural tetrad [active]"
                     /db_xref="CDD:238121"
     Region          671..710
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          717..755
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          760..802
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          836..1207
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          848..880
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          882..935
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          943..978
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          984..1019
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1026..1063
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1134..1176
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1280..1351
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          1367..1416
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1369..1756
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          1421..1459
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1465..1508
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1514..1549
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1554..1639
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1638..1894
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          1646..1684
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1729..1762
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1775..1833
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1841..1875
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..1943
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /coded_by="XM_017021069.3:1195..7026"
                     /db_xref="GeneID:161436"
                     /db_xref="HGNC:HGNC:18197"
                     /db_xref="MIM:618119"
ORIGIN      
        1 mqlalrslal hpervlvatg qvgkepyici wdsytvqtis vlkdvhthgi aclafdldgq
       61 rlvsvgldsk navcvwdwkr gkmlsmapgh tdrifdiswd lyqpnklvsc gvkhikfwsl
      121 cgnaltpkrg vfgktgdlqt ilclacarde ltysgalngd iyvwkginli rtiqgahaag
      181 ifsmnaceeg fatggrdgci rlwdltfkpi tvidlretdq gykglsvrsv cwrgdhilvg
      241 tqdseifeiv vqernkpfli mqghcegelw alavhptkpl avtgsddrsv riwslvdhal
      301 iarcnmeepi rcaavnadgi hlalgmkdgs ftvlrvrdmt evvhikdrke aihelkyspd
      361 gtylavgcnd ssvdiygvaq rykkvgeclg slsfithldw ssdsrylqtn dgngkrlfyr
      421 mpggkevtst eeikgvhwas wtcvsglevn giwpkysdin dinsvdgnyi gqvlvtaddy
      481 giiklfrypc lrkgakfrky ighsahvtnv rwshdyqwvi siggadhsvf qwkfiperkl
      541 kdavhiapqe sladshsdes dsdlsdvpel dseieqetql tyrrqvyked lpqlkeqcke
      601 kqksatskrr erapgnsirl hfvhgyrgyd crsnlfytqi geivyhvaav gviynrqqnt
      661 qrfylghddd ilcltihplk dyvatgqvgr dpsihiwdte tikplsilkg hhqygvsavd
      721 fsadgkrlas vgiddshtvv lwdwkkgekl siargskdki fvvkmnpyvp dklitagikh
      781 mkfwrkaggg ligrkgyigt lgkndtmmca vygwteemaf sgtstgdvci wrdiflvktv
      841 kahdgpvfsm halekgfvtg gkdgivalwd dsferclkty aikraalapg skglllednp
      901 siraislghg hilvgtknge ilevdksgpi tllvqghmeg evwglathpy lpicatvsdd
      961 ktlriwdlsp shcmlavrkl kkggrcccfs pdgkalavgl ndgsflmana dtledlvsfh
     1021 hrkdmisdir fspgsgkyla vashdsfidi ynvmsskrvg ickgatsyit hidwdirgkl
     1081 lqvntgakeq lffeaprgkk qtipsvevek iawaswtsvl glccegiwpv igevtdvtas
     1141 cltsdkmvla tgddlgfvkl fryptkgkfg kfkryvahst hvtnvrwtyd dsmlvtlggt
     1201 dmslmvwtne megyrekrpc dseesdidse edggydsdvt reneisytir alstnirpml
     1261 gikphlqqke psiderqgvv rgsrppvsra ppqpeklqtn nvgkkkrpie dlvlelifgy
     1321 rgrdcrnnvh ylndgddiiy htasvgilhn vatgsqsfyq ehnddilclt vnqhpkfini
     1381 vatgqvgdsa dmsatapsih iwdamnkqtl silrcyhskg vcsvsfsatg klllsvgldp
     1441 ehtitiwrwq egakiasrag hnqrifvaef rpdsdtqfvs vgvkhvkfwt lagrallskk
     1501 gllstledar mqtmlaiafg annltftgti sgdvcvwkdh ilcrivarah ngpvfamytt
     1561 lrdglivtgg kerpskegga vklwdqelrr crafrletgq atdcvrsvcr gkgkilvgtr
     1621 naeiievgek naacnilvng hvdgpiwgla thpsrdffls aaedgtvrlw diadkkmlnk
     1681 vnlghaartv cyspegdmva igmkngefii llvsslkiwg kkrdrrcaih dirfspdsry
     1741 lavgssensv dfydltlgpt lnrisyckdi psfviqmdfs adssylqvss gcykrhvyev
     1801 psgkhlmdha aidritwatw tsilgdevlg iwsrhaekad vncacvshsg islvtgddfg
     1861 mvklfdfpcp ekfvslcfvy yyqftpnfdv lssalfpiyl kcfvliskff pklsksiyfe
     1921 ikairnkssp ssntifgtil qkl
//
LOCUS       XP_011534836            1943 aa            linear   PRI 05-AUG-2025
DEFINITION  echinoderm microtubule-associated protein-like 5 isoform X14 [Homo
            sapiens].
ACCESSION   XP_011534836
VERSION     XP_011534836.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536534.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1943
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1943
                     /product="echinoderm microtubule-associated protein-like 5
                     isoform X14"
                     /calculated_mol_wt=216338
     Region          4..379
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          7..45
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          51..89
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          94..142
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          144..174
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          181..214
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          227..262
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          269..293
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          310..342
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          352..392
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          462..505
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          <613..656
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          666..1004
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Site            order(667,685,691,697..698,710..711,730,734,742..743,
                     755..756,775,780,784..785,803,820,825,831,842..843,859,
                     863,869..870,936..937,955,960,966..967,979..980,998,1002)
                     /site_type="active"
                     /note="structural tetrad [active]"
                     /db_xref="CDD:238121"
     Region          671..710
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          717..755
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          760..802
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          836..1207
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          848..880
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          882..935
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          943..978
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          984..1019
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1026..1063
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1134..1176
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1280..1351
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          1367..1416
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1369..1756
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          1421..1459
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1465..1508
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1514..1549
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1554..1639
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1638..1894
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          1646..1684
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1729..1762
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1775..1833
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1841..1875
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..1943
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /coded_by="XM_011536534.4:145..5976"
                     /db_xref="GeneID:161436"
                     /db_xref="HGNC:HGNC:18197"
                     /db_xref="MIM:618119"
ORIGIN      
        1 mqlalrslal hpervlvatg qvgkepyici wdsytvqtis vlkdvhthgi aclafdldgq
       61 rlvsvgldsk navcvwdwkr gkmlsmapgh tdrifdiswd lyqpnklvsc gvkhikfwsl
      121 cgnaltpkrg vfgktgdlqt ilclacarde ltysgalngd iyvwkginli rtiqgahaag
      181 ifsmnaceeg fatggrdgci rlwdltfkpi tvidlretdq gykglsvrsv cwrgdhilvg
      241 tqdseifeiv vqernkpfli mqghcegelw alavhptkpl avtgsddrsv riwslvdhal
      301 iarcnmeepi rcaavnadgi hlalgmkdgs ftvlrvrdmt evvhikdrke aihelkyspd
      361 gtylavgcnd ssvdiygvaq rykkvgeclg slsfithldw ssdsrylqtn dgngkrlfyr
      421 mpggkevtst eeikgvhwas wtcvsglevn giwpkysdin dinsvdgnyi gqvlvtaddy
      481 giiklfrypc lrkgakfrky ighsahvtnv rwshdyqwvi siggadhsvf qwkfiperkl
      541 kdavhiapqe sladshsdes dsdlsdvpel dseieqetql tyrrqvyked lpqlkeqcke
      601 kqksatskrr erapgnsirl hfvhgyrgyd crsnlfytqi geivyhvaav gviynrqqnt
      661 qrfylghddd ilcltihplk dyvatgqvgr dpsihiwdte tikplsilkg hhqygvsavd
      721 fsadgkrlas vgiddshtvv lwdwkkgekl siargskdki fvvkmnpyvp dklitagikh
      781 mkfwrkaggg ligrkgyigt lgkndtmmca vygwteemaf sgtstgdvci wrdiflvktv
      841 kahdgpvfsm halekgfvtg gkdgivalwd dsferclkty aikraalapg skglllednp
      901 siraislghg hilvgtknge ilevdksgpi tllvqghmeg evwglathpy lpicatvsdd
      961 ktlriwdlsp shcmlavrkl kkggrcccfs pdgkalavgl ndgsflmana dtledlvsfh
     1021 hrkdmisdir fspgsgkyla vashdsfidi ynvmsskrvg ickgatsyit hidwdirgkl
     1081 lqvntgakeq lffeaprgkk qtipsvevek iawaswtsvl glccegiwpv igevtdvtas
     1141 cltsdkmvla tgddlgfvkl fryptkgkfg kfkryvahst hvtnvrwtyd dsmlvtlggt
     1201 dmslmvwtne megyrekrpc dseesdidse edggydsdvt reneisytir alstnirpml
     1261 gikphlqqke psiderqgvv rgsrppvsra ppqpeklqtn nvgkkkrpie dlvlelifgy
     1321 rgrdcrnnvh ylndgddiiy htasvgilhn vatgsqsfyq ehnddilclt vnqhpkfini
     1381 vatgqvgdsa dmsatapsih iwdamnkqtl silrcyhskg vcsvsfsatg klllsvgldp
     1441 ehtitiwrwq egakiasrag hnqrifvaef rpdsdtqfvs vgvkhvkfwt lagrallskk
     1501 gllstledar mqtmlaiafg annltftgti sgdvcvwkdh ilcrivarah ngpvfamytt
     1561 lrdglivtgg kerpskegga vklwdqelrr crafrletgq atdcvrsvcr gkgkilvgtr
     1621 naeiievgek naacnilvng hvdgpiwgla thpsrdffls aaedgtvrlw diadkkmlnk
     1681 vnlghaartv cyspegdmva igmkngefii llvsslkiwg kkrdrrcaih dirfspdsry
     1741 lavgssensv dfydltlgpt lnrisyckdi psfviqmdfs adssylqvss gcykrhvyev
     1801 psgkhlmdha aidritwatw tsilgdevlg iwsrhaekad vncacvshsg islvtgddfg
     1861 mvklfdfpcp ekfvslcfvy yyqftpnfdv lssalfpiyl kcfvliskff pklsksiyfe
     1921 ikairnkssp ssntifgtil qkl
//
LOCUS       XP_047287013            1931 aa            linear   PRI 05-AUG-2025
DEFINITION  echinoderm microtubule-associated protein-like 5 isoform X15 [Homo
            sapiens].
ACCESSION   XP_047287013
VERSION     XP_047287013.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431057.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1931
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1931
                     /product="echinoderm microtubule-associated protein-like 5
                     isoform X15"
                     /calculated_mol_wt=215353
     Region          <2..49
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          58..438
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          64..104
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          110..148
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          153..201
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          203..233
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          240..273
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          286..321
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          328..352
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          369..401
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          411..451
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          521..564
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          <672..715
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          720..1074
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          731..769
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          775..814
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          820..863
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          868..907
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          915..956
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          963..997
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1005..1031
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1047..1072
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1091..1125
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1155..1197
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          <1317..1364
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          1380..1429
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1382..1769
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          1434..1472
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1478..1521
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1527..1562
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1567..1652
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1651..1924
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          1659..1697
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1742..1775
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1788..1846
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1854..1893
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..1931
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /coded_by="XM_047431057.1:451..6246"
                     /db_xref="GeneID:161436"
                     /db_xref="HGNC:HGNC:18197"
                     /db_xref="MIM:618119"
ORIGIN      
        1 maarsapsch lrlewvygyr ghqcrnnlyy taakeivyfv agvgvvyspr ehrqkfyrgh
       61 sddiislalh pervlvatgq vgkepyiciw dsytvqtisv lkdvhthgia clafdldgqr
      121 lvsvgldskn avcvwdwkrg kmlsmapght drifdiswdl yqpnklvscg vkhikfwslc
      181 gnaltpkrgv fgktgdlqti lclacardel tysgalngdi yvwkginlir tiqgahaagi
      241 fsmnaceegf atggrdgcir lwdltfkpit vidlretdqg ykglsvrsvc wrgdhilvgt
      301 qdseifeivv qernkpflim qghcegelwa lavhptkpla vtgsddrsvr iwslvdhali
      361 arcnmeepir caavnadgih lalgmkdgsf tvlrvrdmte vvhikdrkea ihelkyspdg
      421 tylavgcnds svdiygvaqr ykkvgeclgs lsfithldws sdsrylqtnd gngkrlfyrm
      481 pggkevtste eikgvhwasw tcvsglevng iwpkysdind insvdgnyig qvlvtaddyg
      541 iiklfrypcl rkgakfrkyi ghsahvtnvr wshdyqwvis iggadhsvfq wkfiperklk
      601 davhiapqes ladshsdesd sdlsdvpeld seieqetqlt yrrqvykedl pqlkeqckek
      661 qksatskrre rapgnsirlh fvhgyrgydc rsnlfytqig eivyhvaavg viynrqqntq
      721 rfylghdddi lcltihplkd yvatgqvgrd psihiwdtet ikplsilkgh hqygvsavdf
      781 sadgkrlasv giddshtvvl wdwkkgekls iargskdkif vvkmnpyvpd klitagikhm
      841 kfwrkagdvc iwrdiflvkt vkahdgpvfs mhalekgfvt ggkdgivalw ddsferclkt
      901 yaikraalap gskgllledn psiraislgh ghilvgtkng eilevdksgp itllvqghme
      961 gevwglathp ylpicatvsd dktlriwdls pshcmlavrk lkkggrcccf spdgkalavg
     1021 lndgsflman adtledlvsf hhrkdmisdi rfspgsgkyl avashdsfid iynvmsskrv
     1081 gickgatsyi thidwdirgk llqvntgake qlffeaprgk kqtipsveve kiawaswtsv
     1141 lglccegiwp vigevtdvta scltsdkmvl atgddlgfvk lfryptkgkf gkfkryvahs
     1201 thvtnvrwty ddsmlvtlgg tdmslmvwtn emegyrekrp cdseesdids eedggydsdv
     1261 treneisyti ralstnirpm lgikphlqqk epsiderppv srappqpekl qtnnvgkkkr
     1321 piedlvleli fgyrgrdcrn nvhylndgdd iiyhtasvgi lhnvatgsqs fyqehnddil
     1381 cltvnqhpkf inivatgqvg dsadmsatap sihiwdamnk qtlsilrcyh skgvcsvsfs
     1441 atgklllsvg ldpehtitiw rwqegakias raghnqrifv aefrpdsdtq fvsvgvkhvk
     1501 fwtlagrall skkgllstle darmqtmlai afgannltft gtisgdvcvw kdhilcriva
     1561 rahngpvfam yttlrdgliv tggkerpske ggavklwdqe lrrcrafrle tgqatdcvrs
     1621 vcrgkgkilv gtrnaeiiev geknaacnil vnghvdgpiw glathpsrdf flsaaedgtv
     1681 rlwdiadkkm lnkvnlghaa rtvcyspegd mvaigmknge fiillvsslk iwgkkrdrrc
     1741 aihdirfspd srylavgsse nsvdfydltl gptlnrisyc kdipsfviqm dfsadssylq
     1801 vssgcykrhv yevpsgkhlm dhaaidritw atwtsilgde vlgiwsrhae kadvncacvs
     1861 hsgislvtgd dfgmvklfdf pcpekfakhk rflghsphvt nirftsgdrh vvsaggddcs
     1921 lfvwkcvhtp h
//
LOCUS       XP_047287014            1619 aa            linear   PRI 05-AUG-2025
DEFINITION  echinoderm microtubule-associated protein-like 5 isoform X16 [Homo
            sapiens].
ACCESSION   XP_047287014
VERSION     XP_047287014.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431058.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1619
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1619
                     /product="echinoderm microtubule-associated protein-like 5
                     isoform X16"
                     /calculated_mol_wt=180398
     Region          <2..49
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          58..438
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          64..104
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          110..148
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          153..201
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          203..233
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          240..273
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          286..321
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          328..352
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          369..401
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          411..451
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          521..564
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          <672..715
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          725..1063
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Site            order(726,744,750,756..757,769..770,789,793,801..802,
                     814..815,834,839,843..844,862,879,884,890,901..902,918,
                     922,928..929,995..996,1014,1019,1025..1026,1038..1039,
                     1057,1061)
                     /site_type="active"
                     /note="structural tetrad [active]"
                     /db_xref="CDD:238121"
     Region          730..769
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          776..814
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          819..861
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          895..1266
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          907..939
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          941..994
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1002..1037
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1043..1078
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1085..1122
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1193..1235
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1339..1410
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          <1407..>1556
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          1438..1473
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1480..1518
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1526..1566
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..1619
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /coded_by="XM_047431058.1:451..5310"
                     /db_xref="GeneID:161436"
                     /db_xref="HGNC:HGNC:18197"
                     /db_xref="MIM:618119"
ORIGIN      
        1 maarsapsch lrlewvygyr ghqcrnnlyy taakeivyfv agvgvvyspr ehrqkfyrgh
       61 sddiislalh pervlvatgq vgkepyiciw dsytvqtisv lkdvhthgia clafdldgqr
      121 lvsvgldskn avcvwdwkrg kmlsmapght drifdiswdl yqpnklvscg vkhikfwslc
      181 gnaltpkrgv fgktgdlqti lclacardel tysgalngdi yvwkginlir tiqgahaagi
      241 fsmnaceegf atggrdgcir lwdltfkpit vidlretdqg ykglsvrsvc wrgdhilvgt
      301 qdseifeivv qernkpflim qghcegelwa lavhptkpla vtgsddrsvr iwslvdhali
      361 arcnmeepir caavnadgih lalgmkdgsf tvlrvrdmte vvhikdrkea ihelkyspdg
      421 tylavgcnds svdiygvaqr ykkvgeclgs lsfithldws sdsrylqtnd gngkrlfyrm
      481 pggkevtste eikgvhwasw tcvsglevng iwpkysdind insvdgnyig qvlvtaddyg
      541 iiklfrypcl rkgakfrkyi ghsahvtnvr wshdyqwvis iggadhsvfq wkfiperklk
      601 davhiapqes ladshsdesd sdlsdvpeld seieqetqlt yrrqvykedl pqlkeqckek
      661 qksatskrre rapgnsirlh fvhgyrgydc rsnlfytqig eivyhvaavg viynrqqntq
      721 rfylghdddi lcltihplkd yvatgqvgrd psihiwdtet ikplsilkgh hqygvsavdf
      781 sadgkrlasv giddshtvvl wdwkkgekls iargskdkif vvkmnpyvpd klitagikhm
      841 kfwrkagggl igrkgyigtl gkndtmmcav ygwteemafs gtstgdvciw rdiflvktvk
      901 ahdgpvfsmh alekgfvtgg kdgivalwdd sferclktya ikraalapgs kglllednps
      961 iraislghgh ilvgtkngei levdksgpit llvqghmege vwglathpyl picatvsddk
     1021 tlriwdlsps hcmlavrklk kggrcccfsp dgkalavgln dgsflmanad tledlvsfhh
     1081 rkdmisdirf spgsgkylav ashdsfidiy nvmsskrvgi ckgatsyith idwdirgkll
     1141 qvntgakeql ffeaprgkkq tipsveveki awaswtsvlg lccegiwpvi gevtdvtasc
     1201 ltsdkmvlat gddlgfvklf ryptkgkfgk fkryvahsth vtnvrwtydd smlvtlggtd
     1261 mslmvwtnem egyrekrpcd seesdidsee dggydsdvtr eneisytira lstnirpmlg
     1321 ikphlqqkep siderqgvvr gsrppvsrap pqpeklqtnn vgkkkrpied lvlelifgyr
     1381 grdcrnnvhy lndgddiiyh tasvgilhnv atgsqsfyqe hnddilcltv nqhpkfiniv
     1441 atgqvgdsad msatapsihi wdamnkqtls ilrcyhskgv csvsfsatgk lllsvgldpe
     1501 htitiwrwqe gakiasragh nqrifvaefr pdsdtqfvsv gvkhvkfwtl agrallskkg
     1561 llstledarm qtmlaiafga vpsvvmsvcg kitycveswr elttglclpc tppcemdls
//
LOCUS       XP_011534838            1587 aa            linear   PRI 05-AUG-2025
DEFINITION  echinoderm microtubule-associated protein-like 5 isoform X17 [Homo
            sapiens].
ACCESSION   XP_011534838
VERSION     XP_011534838.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536536.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1587
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1587
                     /product="echinoderm microtubule-associated protein-like 5
                     isoform X17"
                     /calculated_mol_wt=177007
     Region          <2..49
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          58..438
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          64..104
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          110..148
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          153..201
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          203..233
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          240..273
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          286..321
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          328..352
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          369..401
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          411..451
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          521..564
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          <672..715
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          725..1063
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Site            order(726,744,750,756..757,769..770,789,793,801..802,
                     814..815,834,839,843..844,862,879,884,890,901..902,918,
                     922,928..929,995..996,1014,1019,1025..1026,1038..1039,
                     1057,1061)
                     /site_type="active"
                     /note="structural tetrad [active]"
                     /db_xref="CDD:238121"
     Region          730..769
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          776..814
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          819..861
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          895..1266
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          907..939
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          941..994
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1002..1037
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1043..1078
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1085..1122
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1193..1235
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1339..1410
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          <1407..>1556
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          1438..1473
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1480..1518
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1526..1566
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..1587
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /coded_by="XM_011536536.3:451..5214"
                     /db_xref="GeneID:161436"
                     /db_xref="HGNC:HGNC:18197"
                     /db_xref="MIM:618119"
ORIGIN      
        1 maarsapsch lrlewvygyr ghqcrnnlyy taakeivyfv agvgvvyspr ehrqkfyrgh
       61 sddiislalh pervlvatgq vgkepyiciw dsytvqtisv lkdvhthgia clafdldgqr
      121 lvsvgldskn avcvwdwkrg kmlsmapght drifdiswdl yqpnklvscg vkhikfwslc
      181 gnaltpkrgv fgktgdlqti lclacardel tysgalngdi yvwkginlir tiqgahaagi
      241 fsmnaceegf atggrdgcir lwdltfkpit vidlretdqg ykglsvrsvc wrgdhilvgt
      301 qdseifeivv qernkpflim qghcegelwa lavhptkpla vtgsddrsvr iwslvdhali
      361 arcnmeepir caavnadgih lalgmkdgsf tvlrvrdmte vvhikdrkea ihelkyspdg
      421 tylavgcnds svdiygvaqr ykkvgeclgs lsfithldws sdsrylqtnd gngkrlfyrm
      481 pggkevtste eikgvhwasw tcvsglevng iwpkysdind insvdgnyig qvlvtaddyg
      541 iiklfrypcl rkgakfrkyi ghsahvtnvr wshdyqwvis iggadhsvfq wkfiperklk
      601 davhiapqes ladshsdesd sdlsdvpeld seieqetqlt yrrqvykedl pqlkeqckek
      661 qksatskrre rapgnsirlh fvhgyrgydc rsnlfytqig eivyhvaavg viynrqqntq
      721 rfylghdddi lcltihplkd yvatgqvgrd psihiwdtet ikplsilkgh hqygvsavdf
      781 sadgkrlasv giddshtvvl wdwkkgekls iargskdkif vvkmnpyvpd klitagikhm
      841 kfwrkagggl igrkgyigtl gkndtmmcav ygwteemafs gtstgdvciw rdiflvktvk
      901 ahdgpvfsmh alekgfvtgg kdgivalwdd sferclktya ikraalapgs kglllednps
      961 iraislghgh ilvgtkngei levdksgpit llvqghmege vwglathpyl picatvsddk
     1021 tlriwdlsps hcmlavrklk kggrcccfsp dgkalavgln dgsflmanad tledlvsfhh
     1081 rkdmisdirf spgsgkylav ashdsfidiy nvmsskrvgi ckgatsyith idwdirgkll
     1141 qvntgakeql ffeaprgkkq tipsveveki awaswtsvlg lccegiwpvi gevtdvtasc
     1201 ltsdkmvlat gddlgfvklf ryptkgkfgk fkryvahsth vtnvrwtydd smlvtlggtd
     1261 mslmvwtnem egyrekrpcd seesdidsee dggydsdvtr eneisytira lstnirpmlg
     1321 ikphlqqkep siderqgvvr gsrppvsrap pqpeklqtnn vgkkkrpied lvlelifgyr
     1381 grdcrnnvhy lndgddiiyh tasvgilhnv atgsqsfyqe hnddilcltv nqhpkfiniv
     1441 atgqvgdsad msatapsihi wdamnkqtls ilrcyhskgv csvsfsatgk lllsvgldpe
     1501 htitiwrwqe gakiasragh nqrifvaefr pdsdtqfvsv gvkhvkfwtl agrallskkg
     1561 llstledarm qtmlaiafga vkrrrsg
//
LOCUS       XP_016876559            1482 aa            linear   PRI 05-AUG-2025
DEFINITION  echinoderm microtubule-associated protein-like 5 isoform X18 [Homo
            sapiens].
ACCESSION   XP_016876559
VERSION     XP_016876559.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021070.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1482
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1482
                     /product="echinoderm microtubule-associated protein-like 5
                     isoform X18"
                     /calculated_mol_wt=165701
     Region          <2..49
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          58..438
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          64..104
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          110..148
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          153..201
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          203..233
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          240..273
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          286..321
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          328..352
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          369..401
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          411..451
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          521..564
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          <672..715
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          725..1063
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Site            order(726,744,750,756..757,769..770,789,793,801..802,
                     814..815,834,839,843..844,862,879,884,890,901..902,918,
                     922,928..929,995..996,1014,1019,1025..1026,1038..1039,
                     1057,1061)
                     /site_type="active"
                     /note="structural tetrad [active]"
                     /db_xref="CDD:238121"
     Region          730..769
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          776..814
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          819..861
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          895..1266
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          907..939
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          941..994
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1002..1037
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1043..1078
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1085..1122
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1193..1235
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1339..1410
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     CDS             1..1482
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /coded_by="XM_017021070.2:451..4899"
                     /db_xref="GeneID:161436"
                     /db_xref="HGNC:HGNC:18197"
                     /db_xref="MIM:618119"
ORIGIN      
        1 maarsapsch lrlewvygyr ghqcrnnlyy taakeivyfv agvgvvyspr ehrqkfyrgh
       61 sddiislalh pervlvatgq vgkepyiciw dsytvqtisv lkdvhthgia clafdldgqr
      121 lvsvgldskn avcvwdwkrg kmlsmapght drifdiswdl yqpnklvscg vkhikfwslc
      181 gnaltpkrgv fgktgdlqti lclacardel tysgalngdi yvwkginlir tiqgahaagi
      241 fsmnaceegf atggrdgcir lwdltfkpit vidlretdqg ykglsvrsvc wrgdhilvgt
      301 qdseifeivv qernkpflim qghcegelwa lavhptkpla vtgsddrsvr iwslvdhali
      361 arcnmeepir caavnadgih lalgmkdgsf tvlrvrdmte vvhikdrkea ihelkyspdg
      421 tylavgcnds svdiygvaqr ykkvgeclgs lsfithldws sdsrylqtnd gngkrlfyrm
      481 pggkevtste eikgvhwasw tcvsglevng iwpkysdind insvdgnyig qvlvtaddyg
      541 iiklfrypcl rkgakfrkyi ghsahvtnvr wshdyqwvis iggadhsvfq wkfiperklk
      601 davhiapqes ladshsdesd sdlsdvpeld seieqetqlt yrrqvykedl pqlkeqckek
      661 qksatskrre rapgnsirlh fvhgyrgydc rsnlfytqig eivyhvaavg viynrqqntq
      721 rfylghdddi lcltihplkd yvatgqvgrd psihiwdtet ikplsilkgh hqygvsavdf
      781 sadgkrlasv giddshtvvl wdwkkgekls iargskdkif vvkmnpyvpd klitagikhm
      841 kfwrkagggl igrkgyigtl gkndtmmcav ygwteemafs gtstgdvciw rdiflvktvk
      901 ahdgpvfsmh alekgfvtgg kdgivalwdd sferclktya ikraalapgs kglllednps
      961 iraislghgh ilvgtkngei levdksgpit llvqghmege vwglathpyl picatvsddk
     1021 tlriwdlsps hcmlavrklk kggrcccfsp dgkalavgln dgsflmanad tledlvsfhh
     1081 rkdmisdirf spgsgkylav ashdsfidiy nvmsskrvgi ckgatsyith idwdirgkll
     1141 qvntgakeql ffeaprgkkq tipsveveki awaswtsvlg lccegiwpvi gevtdvtasc
     1201 ltsdkmvlat gddlgfvklf ryptkgkfgk fkryvahsth vtnvrwtydd smlvtlggtd
     1261 mslmvwtnem egyrekrpcd seesdidsee dggydsdvtr eneisytira lstnirpmlg
     1321 ikphlqqkep siderqgvvr gsrppvsrap pqpeklqtnn vgkkkrpied lvlelifgyr
     1381 grdcrnnvhy lndgddiiyh tasvgilhnv atgsqsfyqe hnddilcltv nqhpkfiniv
     1441 atgqviqqtc qvpklpaelv tinvflwqns dqiqipslsq we
//
LOCUS       XP_047287015            1462 aa            linear   PRI 05-AUG-2025
DEFINITION  echinoderm microtubule-associated protein-like 5 isoform X19 [Homo
            sapiens].
ACCESSION   XP_047287015
VERSION     XP_047287015.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431059.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1462
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1462
                     /product="echinoderm microtubule-associated protein-like 5
                     isoform X19"
                     /calculated_mol_wt=163357
     Region          <2..49
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          58..438
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          64..104
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          110..148
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          153..201
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          203..233
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          240..273
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          286..321
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          328..352
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          369..401
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          411..451
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          521..564
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          <672..715
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          725..1063
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Site            order(726,744,750,756..757,769..770,789,793,801..802,
                     814..815,834,839,843..844,862,879,884,890,901..902,918,
                     922,928..929,995..996,1014,1019,1025..1026,1038..1039,
                     1057,1061)
                     /site_type="active"
                     /note="structural tetrad [active]"
                     /db_xref="CDD:238121"
     Region          730..769
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          776..814
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          819..861
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          895..1266
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          907..939
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          941..994
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1002..1037
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1043..1078
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1085..1122
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1193..1235
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1339..1410
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     CDS             1..1462
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /coded_by="XM_047431059.1:451..4839"
                     /db_xref="GeneID:161436"
                     /db_xref="HGNC:HGNC:18197"
                     /db_xref="MIM:618119"
ORIGIN      
        1 maarsapsch lrlewvygyr ghqcrnnlyy taakeivyfv agvgvvyspr ehrqkfyrgh
       61 sddiislalh pervlvatgq vgkepyiciw dsytvqtisv lkdvhthgia clafdldgqr
      121 lvsvgldskn avcvwdwkrg kmlsmapght drifdiswdl yqpnklvscg vkhikfwslc
      181 gnaltpkrgv fgktgdlqti lclacardel tysgalngdi yvwkginlir tiqgahaagi
      241 fsmnaceegf atggrdgcir lwdltfkpit vidlretdqg ykglsvrsvc wrgdhilvgt
      301 qdseifeivv qernkpflim qghcegelwa lavhptkpla vtgsddrsvr iwslvdhali
      361 arcnmeepir caavnadgih lalgmkdgsf tvlrvrdmte vvhikdrkea ihelkyspdg
      421 tylavgcnds svdiygvaqr ykkvgeclgs lsfithldws sdsrylqtnd gngkrlfyrm
      481 pggkevtste eikgvhwasw tcvsglevng iwpkysdind insvdgnyig qvlvtaddyg
      541 iiklfrypcl rkgakfrkyi ghsahvtnvr wshdyqwvis iggadhsvfq wkfiperklk
      601 davhiapqes ladshsdesd sdlsdvpeld seieqetqlt yrrqvykedl pqlkeqckek
      661 qksatskrre rapgnsirlh fvhgyrgydc rsnlfytqig eivyhvaavg viynrqqntq
      721 rfylghdddi lcltihplkd yvatgqvgrd psihiwdtet ikplsilkgh hqygvsavdf
      781 sadgkrlasv giddshtvvl wdwkkgekls iargskdkif vvkmnpyvpd klitagikhm
      841 kfwrkagggl igrkgyigtl gkndtmmcav ygwteemafs gtstgdvciw rdiflvktvk
      901 ahdgpvfsmh alekgfvtgg kdgivalwdd sferclktya ikraalapgs kglllednps
      961 iraislghgh ilvgtkngei levdksgpit llvqghmege vwglathpyl picatvsddk
     1021 tlriwdlsps hcmlavrklk kggrcccfsp dgkalavgln dgsflmanad tledlvsfhh
     1081 rkdmisdirf spgsgkylav ashdsfidiy nvmsskrvgi ckgatsyith idwdirgkll
     1141 qvntgakeql ffeaprgkkq tipsveveki awaswtsvlg lccegiwpvi gevtdvtasc
     1201 ltsdkmvlat gddlgfvklf ryptkgkfgk fkryvahsth vtnvrwtydd smlvtlggtd
     1261 mslmvwtnem egyrekrpcd seesdidsee dggydsdvtr eneisytira lstnirpmlg
     1321 ikphlqqkep siderqgvvr gsrppvsrap pqpeklqtnn vgkkkrpied lvlelifgyr
     1381 grdcrnnvhy lndgddiiyh tasvgilhnv atgsqsfyqe hnddilcltv nqhpkfiniv
     1441 atgqviqqtc qlqlllftsg mq
//
LOCUS       XP_047287016            1179 aa            linear   PRI 05-AUG-2025
DEFINITION  echinoderm microtubule-associated protein-like 5 isoform X20 [Homo
            sapiens].
ACCESSION   XP_047287016
VERSION     XP_047287016.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431060.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1179
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1179
                     /product="echinoderm microtubule-associated protein-like 5
                     isoform X20"
                     /calculated_mol_wt=130477
     Region          <57..317
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          84..116
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          118..171
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          179..214
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          220..255
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          262..299
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          370..412
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          516..587
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          603..652
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          605..992
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          657..695
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          701..744
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          750..785
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          790..875
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          874..1130
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          882..920
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          965..998
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1011..1069
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1077..1111
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..1179
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /coded_by="XM_047431060.1:751..4290"
                     /db_xref="GeneID:161436"
                     /db_xref="HGNC:HGNC:18197"
                     /db_xref="MIM:618119"
ORIGIN      
        1 mnpyvpdkli tagikhmkfw rkagggligr kgyigtlgkn dtmmcavygw teemafsgts
       61 tgdvciwrdi flvktvkahd gpvfsmhale kgfvtggkdg ivalwddsfe rclktyaikr
      121 aalapgskgl llednpsira islghghilv gtkngeilev dksgpitllv qghmegevwg
      181 lathpylpic atvsddktlr iwdlspshcm lavrklkkgg rcccfspdgk alavglndgs
      241 flmanadtle dlvsfhhrkd misdirfspg sgkylavash dsfidiynvm sskrvgickg
      301 atsyithidw dirgkllqvn tgakeqlffe aprgkkqtip svevekiawa swtsvlglcc
      361 egiwpvigev tdvtasclts dkmvlatgdd lgfvklfryp tkgkfgkfkr yvahsthvtn
      421 vrwtyddsml vtlggtdmsl mvwtnemegy rekrpcdsee sdidseedgg ydsdvtrene
      481 isytiralst nirpmlgikp hlqqkepsid erqgvvrgsr ppvsrappqp eklqtnnvgk
      541 kkrpiedlvl elifgyrgrd crnnvhylnd gddiiyhtas vgilhnvatg sqsfyqehnd
      601 dilcltvnqh pkfinivatg qvgdsadmsa tapsihiwda mnkqtlsilr cyhskgvcsv
      661 sfsatgklll svgldpehti tiwrwqegak iasraghnqr ifvaefrpds dtqfvsvgvk
      721 hvkfwtlagr allskkglls tledarmqtm laiafgannl tftgtisgdv cvwkdhilcr
      781 ivarahngpv famyttlrdg livtggkerp skeggavklw dqelrrcraf rletgqatdc
      841 vrsvcrgkgk ilvgtrnaei ievgeknaac nilvnghvdg piwglathps rdfflsaaed
      901 gtvrlwdiad kkmlnkvnlg haartvcysp egdmvaigmk ngefiillvs slkiwgkkrd
      961 rrcaihdirf spdsrylavg ssensvdfyd ltlgptlnri syckdipsfv iqmdfsadss
     1021 ylqvssgcyk rhvyevpsgk hlmdhaaidr itwatwtsil gdevlgiwsr haekadvnca
     1081 cvshsgislv tgddfgmvkl fdfpcpekfv slcfvyyyqf tpnfdvlssa lfpiylkcfv
     1141 liskffpkls ksiyfeikai rnksspssnt ifgtilqkl
//
LOCUS       XP_047287017            1013 aa            linear   PRI 05-AUG-2025
DEFINITION  echinoderm microtubule-associated protein-like 5 isoform X21 [Homo
            sapiens].
ACCESSION   XP_047287017
VERSION     XP_047287017.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431061.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1013
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1013
                     /product="echinoderm microtubule-associated protein-like 5
                     isoform X21"
                     /calculated_mol_wt=113524
     Region          <2..49
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          58..438
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          64..104
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          110..148
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          153..201
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          203..233
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          240..273
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          286..321
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          328..352
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          369..401
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          411..451
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          521..564
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          557..591
                     /region_name="WD40"
                     /note="WD domain, G-beta repeat; pfam00400"
                     /db_xref="CDD:459801"
     Region          <672..715
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          725..1006
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Site            order(726,744,750,756..757,769..770,789,793,801..802,
                     814..815,834,846,852,864,880,884,890..891,911..912,935,
                     939,945..946,957..958,976,981,987..988,1000..1001)
                     /site_type="active"
                     /note="structural tetrad [active]"
                     /db_xref="CDD:238121"
     Region          730..769
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          776..814
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          819..862
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          869..902
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          923..955
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          963..989
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..1013
                     /gene="EML5"
                     /gene_synonym="EMAP-2; EMAP-5; FAP16"
                     /coded_by="XM_047431061.1:451..3492"
                     /db_xref="GeneID:161436"
                     /db_xref="HGNC:HGNC:18197"
                     /db_xref="MIM:618119"
ORIGIN      
        1 maarsapsch lrlewvygyr ghqcrnnlyy taakeivyfv agvgvvyspr ehrqkfyrgh
       61 sddiislalh pervlvatgq vgkepyiciw dsytvqtisv lkdvhthgia clafdldgqr
      121 lvsvgldskn avcvwdwkrg kmlsmapght drifdiswdl yqpnklvscg vkhikfwslc
      181 gnaltpkrgv fgktgdlqti lclacardel tysgalngdi yvwkginlir tiqgahaagi
      241 fsmnaceegf atggrdgcir lwdltfkpit vidlretdqg ykglsvrsvc wrgdhilvgt
      301 qdseifeivv qernkpflim qghcegelwa lavhptkpla vtgsddrsvr iwslvdhali
      361 arcnmeepir caavnadgih lalgmkdgsf tvlrvrdmte vvhikdrkea ihelkyspdg
      421 tylavgcnds svdiygvaqr ykkvgeclgs lsfithldws sdsrylqtnd gngkrlfyrm
      481 pggkevtste eikgvhwasw tcvsglevng iwpkysdind insvdgnyig qvlvtaddyg
      541 iiklfrypcl rkgakfrkyi ghsahvtnvr wshdyqwvis iggadhsvfq wkfiperklk
      601 davhiapqes ladshsdesd sdlsdvpeld seieqetqlt yrrqvykedl pqlkeqckek
      661 qksatskrre rapgnsirlh fvhgyrgydc rsnlfytqig eivyhvaavg viynrqqntq
      721 rfylghdddi lcltihplkd yvatgqvgrd psihiwdtet ikplsilkgh hqygvsavdf
      781 sadgkrlasv giddshtvvl wdwkkgekls iargskdkif vvkmnpyvpd klitagikhm
      841 kfwrkagdvc iwrdiflvkt vkahdgpvfs mhalekgfvt ggkdgivalw ddsferclkt
      901 yaikraalap gskgllledn psiraislgh ghilvgtkng eilevdksgp itllvqghme
      961 gevwglathp ylpicatvsd dktlriwdls pshcmlavrk lkkgvwgati enh
//
LOCUS       XP_047287018             634 aa            linear   PRI 05-AUG-2025
DEFINITION  cochlin isoform X1 [Homo sapiens].
ACCESSION   XP_047287018
VERSION     XP_047287018.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431062.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..634
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..634
                     /product="cochlin isoform X1"
                     /calculated_mol_wt=68345
     Region          95..177
                     /region_name="LCCL"
                     /note="LCCL domain; smart00603"
                     /db_xref="CDD:128866"
     Region          229..412
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Site            order(236,307,359)
                     /site_type="other"
                     /note="metal ion-dependent adhesion site (MIDAS)"
                     /db_xref="CDD:238119"
     Region          450..611
                     /region_name="vWA_collagen"
                     /note="von Willebrand factor (vWF) type A domain;
                     equivalent to the I-domain of integrins. This domain has a
                     variety of functions including: intermolecular adhesion,
                     cell migration, signalling, transcription, and DNA repair.
                     In integrins these domains form...; cd01472"
                     /db_xref="CDD:238749"
     Site            order(457,459,461,528,559)
                     /site_type="other"
                     /note="metal ion-dependent adhesion site (MIDAS)"
                     /db_xref="CDD:238749"
     Site            order(459..461,463,528)
                     /site_type="active"
                     /note="integrin-collagen binding site [active]"
                     /db_xref="CDD:238749"
     Site            order(489,504..505,516..517,519..520)
                     /site_type="active"
                     /note="putative vWF-collagen binding site [active]"
                     /db_xref="CDD:238749"
     CDS             1..634
                     /gene="COCH"
                     /gene_synonym="COCH-5B2; COCH5B2; DFNA9; DFNB110"
                     /coded_by="XM_047431062.1:57..1961"
                     /db_xref="GeneID:1690"
                     /db_xref="HGNC:HGNC:2180"
                     /db_xref="MIM:603196"
ORIGIN      
        1 msaawipalg lgvcllllpg pagsegagew gswgasrrsq glstsgykrd sdpapwasal
       61 ppeeegakve pprgapaltp aadlllltcf shapiaitcf trgldirkek advlcpggcp
      121 leefsvygni vyasvssicg aavhrgvisn sggpvrvysl pgrenyssvd angiqsqmls
      181 rwsasftvtk gksstqeatg qavstahppt gkrlkktpek ktgnkdckad iaflidgsfn
      241 igqrrfnlqk nfvgkvalml gigtegphvg lvqasehpki efylknftsa kdvlfaikev
      301 gfrggnsntd vaermssttv dseerllrgk alkhtaqkff tvdagvrkgi pkvvvvfidg
      361 wpsddieeag ivarefgvnv fivsvakpip eelgmvqdvt fvdkavcrnn gffsyhmpnw
      421 fgttkyvkpl vqklctheqm mcsktcynsv niaflidgss svgdsnfrlm lefvsniakt
      481 feisdigaki aavqftydqr tefsftdyst kenvlavirn irymsggtat gdaisftvrn
      541 vfgpirespn knflvivtdg qsyddvqgpa aaahdagiti fsvgvawapl ddlkdmaskp
      601 keshafftre ftglepivsd virgicrdfl esqq
//
LOCUS       XP_016876560             615 aa            linear   PRI 05-AUG-2025
DEFINITION  cochlin isoform X2 [Homo sapiens].
ACCESSION   XP_016876560
VERSION     XP_016876560.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021071.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..615
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..615
                     /product="cochlin isoform X2"
                     /calculated_mol_wt=66169
     Region          95..177
                     /region_name="LCCL"
                     /note="LCCL domain; smart00603"
                     /db_xref="CDD:128866"
     Region          229..393
                     /region_name="vWA_collagen_alphaI-XII-like"
                     /note="Collagen: The extracellular matrix represents a
                     complex alloy of variable members of diverse protein
                     families defining structural integrity and various
                     physiological functions. The most abundant family is the
                     collagens with more than 20 different...; cd01482"
                     /db_xref="CDD:238759"
     Site            order(236,238,240,307,340)
                     /site_type="other"
                     /note="metal ion-dependent adhesion site (MIDAS)"
                     /db_xref="CDD:238759"
     Site            order(238..240,242,307)
                     /site_type="active"
                     /note="integrin-collagen binding site [active]"
                     /db_xref="CDD:238759"
     Region          431..592
                     /region_name="vWA_collagen"
                     /note="von Willebrand factor (vWF) type A domain;
                     equivalent to the I-domain of integrins. This domain has a
                     variety of functions including: intermolecular adhesion,
                     cell migration, signalling, transcription, and DNA repair.
                     In integrins these domains form...; cd01472"
                     /db_xref="CDD:238749"
     Site            order(438,440,442,509,540)
                     /site_type="other"
                     /note="metal ion-dependent adhesion site (MIDAS)"
                     /db_xref="CDD:238749"
     Site            order(440..442,444,509)
                     /site_type="active"
                     /note="integrin-collagen binding site [active]"
                     /db_xref="CDD:238749"
     Site            order(470,485..486,497..498,500..501)
                     /site_type="active"
                     /note="putative vWF-collagen binding site [active]"
                     /db_xref="CDD:238749"
     CDS             1..615
                     /gene="COCH"
                     /gene_synonym="COCH-5B2; COCH5B2; DFNA9; DFNB110"
                     /coded_by="XM_017021071.2:57..1904"
                     /db_xref="GeneID:1690"
                     /db_xref="HGNC:HGNC:2180"
                     /db_xref="MIM:603196"
ORIGIN      
        1 msaawipalg lgvcllllpg pagsegagew gswgasrrsq glstsgykrd sdpapwasal
       61 ppeeegakve pprgapaltp aadlllltcf shapiaitcf trgldirkek advlcpggcp
      121 leefsvygni vyasvssicg aavhrgvisn sggpvrvysl pgrenyssvd angiqsqmls
      181 rwsasftvtk gksstqeatg qavstahppt gkrlkktpek ktgnkdckad iaflidgsfn
      241 igqrrfnlqk nfvgkvalml gigtegphvg lvqasehpki efylknftsa kdvlfaikev
      301 gfrggnsntg kalkhtaqkf ftvdagvrkg ipkvvvvfid gwpsddieea givarefgvn
      361 vfivsvakpi peelgmvqdv tfvdkavcrn ngffsyhmpn wfgttkyvkp lvqklctheq
      421 mmcsktcyns vniaflidgs ssvgdsnfrl mlefvsniak tfeisdigak iaavqftydq
      481 rtefsftdys tkenvlavir nirymsggta tgdaisftvr nvfgpiresp nknflvivtd
      541 gqsyddvqgp aaaahdagit ifsvgvawap lddlkdmask pkeshafftr eftglepivs
      601 dvirgicrdf lesqq
//
LOCUS       XP_047287019             615 aa            linear   PRI 05-AUG-2025
DEFINITION  cochlin isoform X2 [Homo sapiens].
ACCESSION   XP_047287019
VERSION     XP_047287019.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431063.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..615
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..615
                     /product="cochlin isoform X2"
                     /calculated_mol_wt=66169
     Region          95..177
                     /region_name="LCCL"
                     /note="LCCL domain; smart00603"
                     /db_xref="CDD:128866"
     Region          229..393
                     /region_name="vWA_collagen_alphaI-XII-like"
                     /note="Collagen: The extracellular matrix represents a
                     complex alloy of variable members of diverse protein
                     families defining structural integrity and various
                     physiological functions. The most abundant family is the
                     collagens with more than 20 different...; cd01482"
                     /db_xref="CDD:238759"
     Site            order(236,238,240,307,340)
                     /site_type="other"
                     /note="metal ion-dependent adhesion site (MIDAS)"
                     /db_xref="CDD:238759"
     Site            order(238..240,242,307)
                     /site_type="active"
                     /note="integrin-collagen binding site [active]"
                     /db_xref="CDD:238759"
     Region          431..592
                     /region_name="vWA_collagen"
                     /note="von Willebrand factor (vWF) type A domain;
                     equivalent to the I-domain of integrins. This domain has a
                     variety of functions including: intermolecular adhesion,
                     cell migration, signalling, transcription, and DNA repair.
                     In integrins these domains form...; cd01472"
                     /db_xref="CDD:238749"
     Site            order(438,440,442,509,540)
                     /site_type="other"
                     /note="metal ion-dependent adhesion site (MIDAS)"
                     /db_xref="CDD:238749"
     Site            order(440..442,444,509)
                     /site_type="active"
                     /note="integrin-collagen binding site [active]"
                     /db_xref="CDD:238749"
     Site            order(470,485..486,497..498,500..501)
                     /site_type="active"
                     /note="putative vWF-collagen binding site [active]"
                     /db_xref="CDD:238749"
     CDS             1..615
                     /gene="COCH"
                     /gene_synonym="COCH-5B2; COCH5B2; DFNA9; DFNB110"
                     /coded_by="XM_047431063.1:381..2228"
                     /db_xref="GeneID:1690"
                     /db_xref="HGNC:HGNC:2180"
                     /db_xref="MIM:603196"
ORIGIN      
        1 msaawipalg lgvcllllpg pagsegagew gswgasrrsq glstsgykrd sdpapwasal
       61 ppeeegakve pprgapaltp aadlllltcf shapiaitcf trgldirkek advlcpggcp
      121 leefsvygni vyasvssicg aavhrgvisn sggpvrvysl pgrenyssvd angiqsqmls
      181 rwsasftvtk gksstqeatg qavstahppt gkrlkktpek ktgnkdckad iaflidgsfn
      241 igqrrfnlqk nfvgkvalml gigtegphvg lvqasehpki efylknftsa kdvlfaikev
      301 gfrggnsntg kalkhtaqkf ftvdagvrkg ipkvvvvfid gwpsddieea givarefgvn
      361 vfivsvakpi peelgmvqdv tfvdkavcrn ngffsyhmpn wfgttkyvkp lvqklctheq
      421 mmcsktcyns vniaflidgs ssvgdsnfrl mlefvsniak tfeisdigak iaavqftydq
      481 rtefsftdys tkenvlavir nirymsggta tgdaisftvr nvfgpiresp nknflvivtd
      541 gqsyddvqgp aaaahdagit ifsvgvawap lddlkdmask pkeshafftr eftglepivs
      601 dvirgicrdf lesqq
//
LOCUS       XP_024305274             569 aa            linear   PRI 05-AUG-2025
DEFINITION  cochlin isoform X3 [Homo sapiens].
ACCESSION   XP_024305274
VERSION     XP_024305274.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449506.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..569
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..569
                     /product="cochlin isoform X3"
                     /calculated_mol_wt=61528
     Region          30..112
                     /region_name="LCCL"
                     /note="LCCL domain; smart00603"
                     /db_xref="CDD:128866"
     Region          164..347
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Site            order(171,242,294)
                     /site_type="other"
                     /note="metal ion-dependent adhesion site (MIDAS)"
                     /db_xref="CDD:238759"
     Region          385..546
                     /region_name="vWA_collagen"
                     /note="von Willebrand factor (vWF) type A domain;
                     equivalent to the I-domain of integrins. This domain has a
                     variety of functions including: intermolecular adhesion,
                     cell migration, signalling, transcription, and DNA repair.
                     In integrins these domains form...; cd01472"
                     /db_xref="CDD:238749"
     Site            order(392,394,396,463,494)
                     /site_type="other"
                     /note="metal ion-dependent adhesion site (MIDAS)"
                     /db_xref="CDD:238749"
     Site            order(394..396,398,463)
                     /site_type="active"
                     /note="integrin-collagen binding site [active]"
                     /db_xref="CDD:238749"
     Site            order(424,439..440,451..452,454..455)
                     /site_type="active"
                     /note="putative vWF-collagen binding site [active]"
                     /db_xref="CDD:238749"
     CDS             1..569
                     /gene="COCH"
                     /gene_synonym="COCH-5B2; COCH5B2; DFNA9; DFNB110"
                     /coded_by="XM_024449506.1:57..1766"
                     /db_xref="GeneID:1690"
                     /db_xref="HGNC:HGNC:2180"
                     /db_xref="MIM:603196"
ORIGIN      
        1 msaawipalg lgvcllllpg pagsegaapi aitcftrgld irkekadvlc pggcpleefs
       61 vygnivyasv ssicgaavhr gvisnsggpv rvyslpgren yssvdangiq sqmlsrwsas
      121 ftvtkgksst qeatgqavst ahpptgkrlk ktpekktgnk dckadiafli dgsfnigqrr
      181 fnlqknfvgk valmlgigte gphvglvqas ehpkiefylk nftsakdvlf aikevgfrgg
      241 nsntdvaerm ssttvdseer llrgkalkht aqkfftvdag vrkgipkvvv vfidgwpsdd
      301 ieeagivare fgvnvfivsv akpipeelgm vqdvtfvdka vcrnngffsy hmpnwfgttk
      361 yvkplvqklc theqmmcskt cynsvniafl idgsssvgds nfrlmlefvs niaktfeisd
      421 igakiaavqf tydqrtefsf tdystkenvl avirniryms ggtatgdais ftvrnvfgpi
      481 respnknflv ivtdgqsydd vqgpaaaahd agitifsvgv awaplddlkd maskpkesha
      541 fftreftgle pivsdvirgi crdflesqq
//
LOCUS       XP_047287020             550 aa            linear   PRI 05-AUG-2025
DEFINITION  cochlin isoform X4 [Homo sapiens].
ACCESSION   XP_047287020
VERSION     XP_047287020.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431064.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..550
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..550
                     /product="cochlin isoform X4"
                     /calculated_mol_wt=59352
     Region          30..112
                     /region_name="LCCL"
                     /note="LCCL domain; smart00603"
                     /db_xref="CDD:128866"
     Region          164..328
                     /region_name="vWA_collagen_alphaI-XII-like"
                     /note="Collagen: The extracellular matrix represents a
                     complex alloy of variable members of diverse protein
                     families defining structural integrity and various
                     physiological functions. The most abundant family is the
                     collagens with more than 20 different...; cd01482"
                     /db_xref="CDD:238759"
     Site            order(171,173,175,242,275)
                     /site_type="other"
                     /note="metal ion-dependent adhesion site (MIDAS)"
                     /db_xref="CDD:238759"
     Site            order(173..175,177,242)
                     /site_type="active"
                     /note="integrin-collagen binding site [active]"
                     /db_xref="CDD:238759"
     Region          366..527
                     /region_name="vWA_collagen"
                     /note="von Willebrand factor (vWF) type A domain;
                     equivalent to the I-domain of integrins. This domain has a
                     variety of functions including: intermolecular adhesion,
                     cell migration, signalling, transcription, and DNA repair.
                     In integrins these domains form...; cd01472"
                     /db_xref="CDD:238749"
     Site            order(373,375,377,444,475)
                     /site_type="other"
                     /note="metal ion-dependent adhesion site (MIDAS)"
                     /db_xref="CDD:238749"
     Site            order(375..377,379,444)
                     /site_type="active"
                     /note="integrin-collagen binding site [active]"
                     /db_xref="CDD:238749"
     Site            order(405,420..421,432..433,435..436)
                     /site_type="active"
                     /note="putative vWF-collagen binding site [active]"
                     /db_xref="CDD:238749"
     CDS             1..550
                     /gene="COCH"
                     /gene_synonym="COCH-5B2; COCH5B2; DFNA9; DFNB110"
                     /coded_by="XM_047431064.1:57..1709"
                     /db_xref="GeneID:1690"
                     /db_xref="HGNC:HGNC:2180"
                     /db_xref="MIM:603196"
ORIGIN      
        1 msaawipalg lgvcllllpg pagsegaapi aitcftrgld irkekadvlc pggcpleefs
       61 vygnivyasv ssicgaavhr gvisnsggpv rvyslpgren yssvdangiq sqmlsrwsas
      121 ftvtkgksst qeatgqavst ahpptgkrlk ktpekktgnk dckadiafli dgsfnigqrr
      181 fnlqknfvgk valmlgigte gphvglvqas ehpkiefylk nftsakdvlf aikevgfrgg
      241 nsntgkalkh taqkfftvda gvrkgipkvv vvfidgwpsd dieeagivar efgvnvfivs
      301 vakpipeelg mvqdvtfvdk avcrnngffs yhmpnwfgtt kyvkplvqkl ctheqmmcsk
      361 tcynsvniaf lidgsssvgd snfrlmlefv sniaktfeis digakiaavq ftydqrtefs
      421 ftdystkenv lavirnirym sggtatgdai sftvrnvfgp irespnknfl vivtdgqsyd
      481 dvqgpaaaah dagitifsvg vawaplddlk dmaskpkesh afftreftgl epivsdvirg
      541 icrdflesqq
//
LOCUS       XP_047287021             270 aa            linear   PRI 05-AUG-2025
DEFINITION  dihydrolipoyllysine-residue succinyltransferase component of
            2-oxoglutarate dehydrogenase complex, mitochondrial isoform X1
            [Homo sapiens].
ACCESSION   XP_047287021
VERSION     XP_047287021.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431065.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..270
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..270
                     /product="dihydrolipoyllysine-residue succinyltransferase
                     component of 2-oxoglutarate dehydrogenase complex,
                     mitochondrial isoform X1"
                     /calculated_mol_wt=29598
     Region          <16..270
                     /region_name="sucB"
                     /note="2-oxoglutarate dehydrogenase complex
                     dihydrolipoamide succinyltransferase (E2 component);
                     TIGR01347"
                     /db_xref="CDD:273565"
     CDS             1..270
                     /gene="DLST"
                     /gene_synonym="DLTS; KGD2; PGL7; PPGL7"
                     /coded_by="XM_047431065.1:505..1317"
                     /db_xref="GeneID:1743"
                     /db_xref="HGNC:HGNC:2911"
                     /db_xref="MIM:126063"
ORIGIN      
        1 mppvpspsqp psgkpvsavk ptvapplaep gagkglrseh rekmnrmrqr iaqrlkeaqn
       61 tcamlttfne idmsniqemr arhkeaflkk hnlklgfmsa fvkasafalq eqpvvnavid
      121 dttkevvyrd yidisvavat prglvvpvir nveamnfadi ertitelgek arknelaied
      181 mdggtftisn ggvfgslfgt piinppqsai lgmhgifdrp vaiggkvevr pmmyvaltyd
      241 hrlidgreav tflrkikaav edprvllldl
//
LOCUS       XP_047287022             224 aa            linear   PRI 05-AUG-2025
DEFINITION  dihydrolipoyllysine-residue succinyltransferase component of
            2-oxoglutarate dehydrogenase complex, mitochondrial isoform X2
            [Homo sapiens].
ACCESSION   XP_047287022
VERSION     XP_047287022.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431066.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..224
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..224
                     /product="dihydrolipoyllysine-residue succinyltransferase
                     component of 2-oxoglutarate dehydrogenase complex,
                     mitochondrial isoform X2"
                     /calculated_mol_wt=23005
     Region          71..>147
                     /region_name="sucB"
                     /note="2-oxoglutarate dehydrogenase complex
                     dihydrolipoamide succinyltransferase (E2 component);
                     TIGR01347"
                     /db_xref="CDD:273565"
     CDS             1..224
                     /gene="DLST"
                     /gene_synonym="DLTS; KGD2; PGL7; PPGL7"
                     /coded_by="XM_047431066.1:39..713"
                     /db_xref="GeneID:1743"
                     /db_xref="HGNC:HGNC:2911"
                     /db_xref="MIM:126063"
ORIGIN      
        1 mlsrsrcvsr afsrslsafq kgncplgrrs lpgvslcqgp gypnsrkvvi nnsvfsvrff
       61 rttavckddl vtvktpafae svtegdvrwe kavgdtvaed evvceietdk tsvqvpspan
      121 gvieallvpd ggkveggtpl ftlrktgaap akakpaeapa aaapkaepta aavpppaapi
      181 ptqmppvpsp sqppsgkpvs avkptvappl aepgagkglr sehr
//
LOCUS       XP_005267456             840 aa            linear   PRI 05-AUG-2025
DEFINITION  echinoderm microtubule-associated protein-like 1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_005267456
VERSION     XP_005267456.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267399.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Mar 12, 2015 this sequence version replaced XP_005267456.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..840
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..840
                     /product="echinoderm microtubule-associated protein-like 1
                     isoform X1"
                     /calculated_mol_wt=92697
     Region          29..85
                     /region_name="TD_EMAP1"
                     /note="trimerization domain of echinoderm
                     microtubule-associated protein-like 1; cd21947"
                     /db_xref="CDD:409268"
     Site            order(40..41,43..44,47..48,50..51,54..55,57..58,61..62,
                     64..65,68..69,71..73,75..76,78)
                     /site_type="other"
                     /note="putative trimer interface [polypeptide binding]"
                     /db_xref="CDD:409268"
     Region          213..284
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          287..334
                     /region_name="WD40"
                     /note="WD40 repeats; smart00320"
                     /db_xref="CDD:197651"
     Region          300..348
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          353..393
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          369..724
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          400..440
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          446..479
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          488..526
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          532..566
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          571..610
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          617..648
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          654..694
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          695..>840
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          767..804
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          812..839
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..840
                     /gene="EML1"
                     /gene_synonym="BH; ELP79; EMAP; EMAP-1; EMAPL"
                     /coded_by="XM_005267399.4:94..2616"
                     /db_xref="GeneID:2009"
                     /db_xref="HGNC:HGNC:3330"
                     /db_xref="MIM:602033"
ORIGIN      
        1 mmyneigeak kiterfidpd keleimilnd sasaassmev tdriasleqr vqmqeddiql
       61 lksaladvvr rlniteeqqa vlnrkgptka rplmqtlplr ttvnngtvlp kkptgslpsp
      121 sgvrketavp atksnikrts sservspggr resngdsrgn rnrtgstsss ssgkknsesk
      181 pkepvfsaal lslspksqgk rrvthckeeg yvkmflrgrp vtmympkdqv dsysleakve
      241 lptkrlklew vygyrgrdcr nnlyllptge tvyfiasvvv lynveeqlqr hyaghnddvk
      301 clavhpdrit iatgqvagts kdgkqlpphv riwdsvtlnt lhvigigffd ravtciafsk
      361 snggtnlcav ddsndhvlsv wdwqkeekla dvkcsneavf aadfhptdtn iivtcgkshl
      421 yfwtlegssl nkkqglfekq ekpkfvlcvt fsengdtitg dssgnilvwg kgtnrisyav
      481 qgaheggifa lcmlrdgtlv sgggkdrkli swsgnyqklr kteipeqfgp irtvaegkgd
      541 viligttrnf vlqgtlsgdf tpitqghtde lwglaihask sqfltcghdk hatlwdavgh
      601 rpvwdkiied paqssgfhps gsvvavgtlt grwfvfdtet kdlvtvhtdg neqlsvmrys
      661 pdgnflaigs hdnciyiygv sdngrkytrv gkcsghssfi thldwsvnsq flvsnsgdye
      721 ilywvpsack qvvsvettrd iewatytctl gfhvfgvwpe gsdgtdinav crahekklls
      781 tgddfgkvhl fsypcsqfra pshiygghss hvtnvdflce dshlistggk dtsimqwrvi
//
LOCUS       XP_005267454             834 aa            linear   PRI 05-AUG-2025
DEFINITION  echinoderm microtubule-associated protein-like 1 isoform X2 [Homo
            sapiens].
ACCESSION   XP_005267454
VERSION     XP_005267454.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267397.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..834
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..834
                     /product="echinoderm microtubule-associated protein-like 1
                     isoform X2"
                     /calculated_mol_wt=91822
     Region          22..79
                     /region_name="TD_EMAP1"
                     /note="trimerization domain of echinoderm
                     microtubule-associated protein-like 1; cd21947"
                     /db_xref="CDD:409268"
     Site            order(34..35,37..38,41..42,44..45,48..49,51..52,55..56,
                     58..59,62..63,65..67,69..70,72)
                     /site_type="other"
                     /note="putative trimer interface [polypeptide binding]"
                     /db_xref="CDD:409268"
     Region          207..278
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          281..328
                     /region_name="WD40"
                     /note="WD40 repeats; smart00320"
                     /db_xref="CDD:197651"
     Region          294..342
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          347..387
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          363..718
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          394..434
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          440..473
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          482..520
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          526..560
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          565..604
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          611..642
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          648..688
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          689..>834
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          761..798
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          806..833
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..834
                     /gene="EML1"
                     /gene_synonym="BH; ELP79; EMAP; EMAP-1; EMAPL"
                     /coded_by="XM_005267397.2:65..2569"
                     /db_xref="GeneID:2009"
                     /db_xref="HGNC:HGNC:3330"
                     /db_xref="MIM:602033"
ORIGIN      
        1 medgfssyss lydtssllqf cnddsasaas smevtdrias leqrvqmqed diqllksala
       61 dvvrrlnite eqqavlnrkg ptkarplmqt lplrttvnng tvlpkkptgs lpspsgvrke
      121 tavpatksni krtssservs pggrresngd srgnrnrtgs tsssssgkkn seskpkepvf
      181 saallslspk sqgkrrvthc keegyvkmfl rgrpvtmymp kdqvdsysle akvelptkrl
      241 klewvygyrg rdcrnnlyll ptgetvyfia svvvlynvee qlqrhyaghn ddvkclavhp
      301 dritiatgqv agtskdgkql pphvriwdsv tlntlhvigi gffdravtci afsksnggtn
      361 lcavddsndh vlsvwdwqke ekladvkcsn eavfaadfhp tdtniivtcg kshlyfwtle
      421 gsslnkkqgl fekqekpkfv lcvtfsengd titgdssgni lvwgkgtnri syavqgaheg
      481 gifalcmlrd gtlvsgggkd rkliswsgny qklrkteipe qfgpirtvae gkgdviligt
      541 trnfvlqgtl sgdftpitqg htdelwglai hasksqfltc ghdkhatlwd avghrpvwdk
      601 iiedpaqssg fhpsgsvvav gtltgrwfvf dtetkdlvtv htdgneqlsv mryspdgnfl
      661 aigshdnciy iygvsdngrk ytrvgkcsgh ssfithldws vnsqflvsns gdyeilywvp
      721 sackqvvsve ttrdiewaty tctlgfhvfg vwpegsdgtd inavcrahek kllstgddfg
      781 kvhlfsypcs qfrapshiyg ghsshvtnvd flcedshlis tggkdtsimq wrvi
//
LOCUS       XP_005267455             821 aa            linear   PRI 05-AUG-2025
DEFINITION  echinoderm microtubule-associated protein-like 1 isoform X3 [Homo
            sapiens].
ACCESSION   XP_005267455
VERSION     XP_005267455.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267398.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..821
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..821
                     /product="echinoderm microtubule-associated protein-like 1
                     isoform X3"
                     /calculated_mol_wt=90177
     Region          19..66
                     /region_name="TD_EMAP1"
                     /note="trimerization domain of echinoderm
                     microtubule-associated protein-like 1; cd21947"
                     /db_xref="CDD:409268"
     Site            order(21..22,24..25,28..29,31..32,35..36,38..39,42..43,
                     45..46,49..50,52..54,56..57,59)
                     /site_type="other"
                     /note="putative trimer interface [polypeptide binding]"
                     /db_xref="CDD:409268"
     Region          194..265
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          268..315
                     /region_name="WD40"
                     /note="WD40 repeats; smart00320"
                     /db_xref="CDD:197651"
     Region          281..329
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          334..374
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          350..705
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          381..421
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          427..460
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          469..507
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          513..547
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          552..591
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          598..629
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          635..675
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          676..>821
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          748..785
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          793..820
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..821
                     /gene="EML1"
                     /gene_synonym="BH; ELP79; EMAP; EMAP-1; EMAPL"
                     /coded_by="XM_005267398.3:112..2577"
                     /db_xref="GeneID:2009"
                     /db_xref="HGNC:HGNC:3330"
                     /db_xref="MIM:602033"
ORIGIN      
        1 msdgegpsad dsasaassme vtdriasleq rvqmqeddiq llksaladvv rrlniteeqq
       61 avlnrkgptk arplmqtlpl rttvnngtvl pkkptgslps psgvrketav patksnikrt
      121 ssservspgg rresngdsrg nrnrtgstss sssgkknses kpkepvfsaa llslspksqg
      181 krrvthckee gyvkmflrgr pvtmympkdq vdsysleakv elptkrlkle wvygyrgrdc
      241 rnnlyllptg etvyfiasvv vlynveeqlq rhyaghnddv kclavhpdri tiatgqvagt
      301 skdgkqlpph vriwdsvtln tlhvigigff dravtciafs ksnggtnlca vddsndhvls
      361 vwdwqkeekl advkcsneav faadfhptdt niivtcgksh lyfwtlegss lnkkqglfek
      421 qekpkfvlcv tfsengdtit gdssgnilvw gkgtnrisya vqgaheggif alcmlrdgtl
      481 vsgggkdrkl iswsgnyqkl rkteipeqfg pirtvaegkg dviligttrn fvlqgtlsgd
      541 ftpitqghtd elwglaihas ksqfltcghd khatlwdavg hrpvwdkiie dpaqssgfhp
      601 sgsvvavgtl tgrwfvfdte tkdlvtvhtd gneqlsvmry spdgnflaig shdnciyiyg
      661 vsdngrkytr vgkcsghssf ithldwsvns qflvsnsgdy eilywvpsac kqvvsvettr
      721 diewatytct lgfhvfgvwp egsdgtdina vcrahekkll stgddfgkvh lfsypcsqfr
      781 apshiygghs shvtnvdflc edshlistgg kdtsimqwrv i
//
LOCUS       XP_011534844             796 aa            linear   PRI 05-AUG-2025
DEFINITION  echinoderm microtubule-associated protein-like 1 isoform X5 [Homo
            sapiens].
ACCESSION   XP_011534844
VERSION     XP_011534844.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536542.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..796
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..796
                     /product="echinoderm microtubule-associated protein-like 1
                     isoform X5"
                     /calculated_mol_wt=87737
     Region          29..85
                     /region_name="TD_EMAP1"
                     /note="trimerization domain of echinoderm
                     microtubule-associated protein-like 1; cd21947"
                     /db_xref="CDD:409268"
     Site            order(40..41,43..44,47..48,50..51,54..55,57..58,61..62,
                     64..65,68..69,71..73,75..76,78)
                     /site_type="other"
                     /note="putative trimer interface [polypeptide binding]"
                     /db_xref="CDD:409268"
     Region          213..284
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          278..680
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          300..348
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          353..393
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          399..441
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          447..482
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          488..561
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          569..604
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          610..650
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          651..>796
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          723..760
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          768..795
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..796
                     /gene="EML1"
                     /gene_synonym="BH; ELP79; EMAP; EMAP-1; EMAPL"
                     /coded_by="XM_011536542.4:94..2484"
                     /db_xref="GeneID:2009"
                     /db_xref="HGNC:HGNC:3330"
                     /db_xref="MIM:602033"
ORIGIN      
        1 mmyneigeak kiterfidpd keleimilnd sasaassmev tdriasleqr vqmqeddiql
       61 lksaladvvr rlniteeqqa vlnrkgptka rplmqtlplr ttvnngtvlp kkptgslpsp
      121 sgvrketavp atksnikrts sservspggr resngdsrgn rnrtgstsss ssgkknsesk
      181 pkepvfsaal lslspksqgk rrvthckeeg yvkmflrgrp vtmympkdqv dsysleakve
      241 lptkrlklew vygyrgrdcr nnlyllptge tvyfiasvvv lynveeqlqr hyaghnddvk
      301 clavhpdrit iatgqvagts kdgkqlpphv riwdsvtlnt lhvigigffd ravtciafsk
      361 snggtnlcav ddsndhvlsv wdwqkeekla dvkcsneavf aadfhptdtn iivtcgkshl
      421 yfwtlegssl nkkqglfekq ekpkfvlcvt fsengdtitg dssgnilvwg kgtnrisyav
      481 qgaheggifa lcmlrdgtlv sgggkdrkli swsgnyqklr kteipeqfgp irtvaegkgd
      541 viligttrnf vlqgtlsgdf tpitqdpaqs sgfhpsgsvv avgtltgrwf vfdtetkdlv
      601 tvhtdgneql svmryspdgn flaigshdnc iyiygvsdng rkytrvgkcs ghssfithld
      661 wsvnsqflvs nsgdyeilyw vpsackqvvs vettrdiewa tytctlgfhv fgvwpegsdg
      721 tdinavcrah ekkllstgdd fgkvhlfsyp csqfrapshi ygghsshvtn vdflcedshl
      781 istggkdtsi mqwrvi
//
LOCUS       XP_024305275             627 aa            linear   PRI 05-AUG-2025
DEFINITION  echinoderm microtubule-associated protein-like 1 isoform X8 [Homo
            sapiens].
ACCESSION   XP_024305275
VERSION     XP_024305275.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449507.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..627
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..627
                     /product="echinoderm microtubule-associated protein-like 1
                     isoform X8"
                     /calculated_mol_wt=69406
     Region          1..71
                     /region_name="HELP"
                     /note="HELP motif; pfam03451"
                     /db_xref="CDD:460922"
     Region          74..121
                     /region_name="WD40"
                     /note="WD domain, G-beta repeat; pfam00400"
                     /db_xref="CDD:459801"
     Region          87..135
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          140..180
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          156..511
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          187..227
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          233..269
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          275..313
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          319..353
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          358..397
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          404..435
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          441..481
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          482..>627
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          554..591
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          599..626
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..627
                     /gene="EML1"
                     /gene_synonym="BH; ELP79; EMAP; EMAP-1; EMAPL"
                     /coded_by="XM_024449507.1:294..2177"
                     /db_xref="GeneID:2009"
                     /db_xref="HGNC:HGNC:3330"
                     /db_xref="MIM:602033"
ORIGIN      
        1 mflrgrpvtm ympkdqvdsy sleakvelpt krlklewvyg yrgrdcrnnl yllptgetvy
       61 fiasvvvlyn veeqlqrhya ghnddvkcla vhpdritiat gqvagtskdg kqlpphvriw
      121 dsvtlntlhv igigffdrav tciafsksng gtnlcavdds ndhvlsvwdw qkeekladvk
      181 csneavfaad fhptdtniiv tcgkshlyfw tlegsslnkk qglfekqekp kfvlcvtfse
      241 ngdtitgdss gnilvwgkgt nrisyavqga heggifalcm lrdgtlvsgg gkdrklisws
      301 gnyqklrkte ipeqfgpirt vaegkgdvil igttrnfvlq gtlsgdftpi tqghtdelwg
      361 laihasksqf ltcghdkhat lwdavghrpv wdkiiedpaq ssgfhpsgsv vavgtltgrw
      421 fvfdtetkdl vtvhtdgneq lsvmryspdg nflaigshdn ciyiygvsdn grkytrvgkc
      481 sghssfithl dwsvnsqflv snsgdyeily wvpsackqvv svettrdiew atytctlgfh
      541 vfgvwpegsd gtdinavcra hekkllstgd dfgkvhlfsy pcsqfrapsh iygghsshvt
      601 nvdflcedsh listggkdts imqwrvi
//
LOCUS       XP_047287025             480 aa            linear   PRI 05-AUG-2025
DEFINITION  RAC-alpha serine/threonine-protein kinase isoform X1 [Homo
            sapiens].
ACCESSION   XP_047287025
VERSION     XP_047287025.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431069.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..480
                     /product="RAC-alpha serine/threonine-protein kinase
                     isoform X1"
                     /calculated_mol_wt=55556
     Region          4..111
                     /region_name="PH_PKB"
                     /note="Protein Kinase B-like pleckstrin homology (PH)
                     domain; cd01241"
                     /db_xref="CDD:269947"
     Site            order(14,16..19,23,25,52..53,55,86)
                     /site_type="other"
                     /note="phosphoinositide binding site [chemical binding]"
                     /db_xref="CDD:269947"
     Region          124..479
                     /region_name="STKc_PKB_alpha"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     Protein Kinase B alpha (also called Akt1); cd05594"
                     /db_xref="CDD:270746"
     Site            order(156..157,159..160,164,177,179,191,194,211,227..230,
                     234,236,240,274,276,278..279,281,291..292,295,309..316,
                     341,347,350,438,442)
                     /site_type="active"
                     /db_xref="CDD:270746"
     Site            order(156..157,159,164,177,179,211,227..230,234,274,276,
                     278..279,281,291..292,438)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270746"
     Site            order(160,191,194,234,236,240,274,276,278,295,309..316,
                     341,347,350,442)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270746"
     Site            291..314
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270746"
     Site            450
                     /site_type="other"
                     /note="turn motif phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:270746"
     Site            469..474
                     /site_type="other"
                     /note="hydrophobic motif (HM)"
                     /db_xref="CDD:270746"
     CDS             1..480
                     /gene="AKT1"
                     /gene_synonym="AKT; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA"
                     /coded_by="XM_047431069.1:1347..2789"
                     /db_xref="GeneID:207"
                     /db_xref="HGNC:HGNC:391"
                     /db_xref="MIM:164730"
ORIGIN      
        1 msdvaivkeg wlhkrgeyik twrpryfllk ndgtfigyke rpqdvdqrea plnnfsvaqc
       61 qlmkterprp ntfiirclqw ttviertfhv etpeereewt taiqtvadgl kkqeeeemdf
      121 rsgspsdnsg aeemevslak pkhrvtmnef eylkllgkgt fgkvilvkek atgryyamki
      181 lkkevivakd evahtltenr vlqnsrhpfl talkysfqth drlcfvmeya nggelffhls
      241 rervfsedra rfygaeivsa ldylhseknv vyrdlklenl mldkdghiki tdfglckegi
      301 kdgatmktfc gtpeylapev ledndygrav dwwglgvvmy emmcgrlpfy nqdheklfel
      361 ilmeeirfpr tlgpeaksll sgllkkdpkq rlgggsedak eimqhrffag ivwqhvyekk
      421 lsppfkpqvt setdtryfde eftaqmitit ppdqddsmec vdserrphfp qfsysasgta
//
LOCUS       XP_047287026             480 aa            linear   PRI 05-AUG-2025
DEFINITION  RAC-alpha serine/threonine-protein kinase isoform X1 [Homo
            sapiens].
ACCESSION   XP_047287026
VERSION     XP_047287026.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431070.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..480
                     /product="RAC-alpha serine/threonine-protein kinase
                     isoform X1"
                     /calculated_mol_wt=55556
     Region          4..111
                     /region_name="PH_PKB"
                     /note="Protein Kinase B-like pleckstrin homology (PH)
                     domain; cd01241"
                     /db_xref="CDD:269947"
     Site            order(14,16..19,23,25,52..53,55,86)
                     /site_type="other"
                     /note="phosphoinositide binding site [chemical binding]"
                     /db_xref="CDD:269947"
     Region          124..479
                     /region_name="STKc_PKB_alpha"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     Protein Kinase B alpha (also called Akt1); cd05594"
                     /db_xref="CDD:270746"
     Site            order(156..157,159..160,164,177,179,191,194,211,227..230,
                     234,236,240,274,276,278..279,281,291..292,295,309..316,
                     341,347,350,438,442)
                     /site_type="active"
                     /db_xref="CDD:270746"
     Site            order(156..157,159,164,177,179,211,227..230,234,274,276,
                     278..279,281,291..292,438)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270746"
     Site            order(160,191,194,234,236,240,274,276,278,295,309..316,
                     341,347,350,442)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270746"
     Site            291..314
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270746"
     Site            450
                     /site_type="other"
                     /note="turn motif phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:270746"
     Site            469..474
                     /site_type="other"
                     /note="hydrophobic motif (HM)"
                     /db_xref="CDD:270746"
     CDS             1..480
                     /gene="AKT1"
                     /gene_synonym="AKT; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA"
                     /coded_by="XM_047431070.1:1135..2577"
                     /db_xref="GeneID:207"
                     /db_xref="HGNC:HGNC:391"
                     /db_xref="MIM:164730"
ORIGIN      
        1 msdvaivkeg wlhkrgeyik twrpryfllk ndgtfigyke rpqdvdqrea plnnfsvaqc
       61 qlmkterprp ntfiirclqw ttviertfhv etpeereewt taiqtvadgl kkqeeeemdf
      121 rsgspsdnsg aeemevslak pkhrvtmnef eylkllgkgt fgkvilvkek atgryyamki
      181 lkkevivakd evahtltenr vlqnsrhpfl talkysfqth drlcfvmeya nggelffhls
      241 rervfsedra rfygaeivsa ldylhseknv vyrdlklenl mldkdghiki tdfglckegi
      301 kdgatmktfc gtpeylapev ledndygrav dwwglgvvmy emmcgrlpfy nqdheklfel
      361 ilmeeirfpr tlgpeaksll sgllkkdpkq rlgggsedak eimqhrffag ivwqhvyekk
      421 lsppfkpqvt setdtryfde eftaqmitit ppdqddsmec vdserrphfp qfsysasgta
//
LOCUS       XP_047287027             480 aa            linear   PRI 05-AUG-2025
DEFINITION  RAC-alpha serine/threonine-protein kinase isoform X1 [Homo
            sapiens].
ACCESSION   XP_047287027
VERSION     XP_047287027.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431071.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..480
                     /product="RAC-alpha serine/threonine-protein kinase
                     isoform X1"
                     /calculated_mol_wt=55556
     Region          4..111
                     /region_name="PH_PKB"
                     /note="Protein Kinase B-like pleckstrin homology (PH)
                     domain; cd01241"
                     /db_xref="CDD:269947"
     Site            order(14,16..19,23,25,52..53,55,86)
                     /site_type="other"
                     /note="phosphoinositide binding site [chemical binding]"
                     /db_xref="CDD:269947"
     Region          124..479
                     /region_name="STKc_PKB_alpha"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     Protein Kinase B alpha (also called Akt1); cd05594"
                     /db_xref="CDD:270746"
     Site            order(156..157,159..160,164,177,179,191,194,211,227..230,
                     234,236,240,274,276,278..279,281,291..292,295,309..316,
                     341,347,350,438,442)
                     /site_type="active"
                     /db_xref="CDD:270746"
     Site            order(156..157,159,164,177,179,211,227..230,234,274,276,
                     278..279,281,291..292,438)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270746"
     Site            order(160,191,194,234,236,240,274,276,278,295,309..316,
                     341,347,350,442)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270746"
     Site            291..314
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270746"
     Site            450
                     /site_type="other"
                     /note="turn motif phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:270746"
     Site            469..474
                     /site_type="other"
                     /note="hydrophobic motif (HM)"
                     /db_xref="CDD:270746"
     CDS             1..480
                     /gene="AKT1"
                     /gene_synonym="AKT; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA"
                     /coded_by="XM_047431071.1:1052..2494"
                     /db_xref="GeneID:207"
                     /db_xref="HGNC:HGNC:391"
                     /db_xref="MIM:164730"
ORIGIN      
        1 msdvaivkeg wlhkrgeyik twrpryfllk ndgtfigyke rpqdvdqrea plnnfsvaqc
       61 qlmkterprp ntfiirclqw ttviertfhv etpeereewt taiqtvadgl kkqeeeemdf
      121 rsgspsdnsg aeemevslak pkhrvtmnef eylkllgkgt fgkvilvkek atgryyamki
      181 lkkevivakd evahtltenr vlqnsrhpfl talkysfqth drlcfvmeya nggelffhls
      241 rervfsedra rfygaeivsa ldylhseknv vyrdlklenl mldkdghiki tdfglckegi
      301 kdgatmktfc gtpeylapev ledndygrav dwwglgvvmy emmcgrlpfy nqdheklfel
      361 ilmeeirfpr tlgpeaksll sgllkkdpkq rlgggsedak eimqhrffag ivwqhvyekk
      421 lsppfkpqvt setdtryfde eftaqmitit ppdqddsmec vdserrphfp qfsysasgta
//
LOCUS       XP_047287028             480 aa            linear   PRI 05-AUG-2025
DEFINITION  RAC-alpha serine/threonine-protein kinase isoform X1 [Homo
            sapiens].
ACCESSION   XP_047287028
VERSION     XP_047287028.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431072.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..480
                     /product="RAC-alpha serine/threonine-protein kinase
                     isoform X1"
                     /calculated_mol_wt=55556
     Region          4..111
                     /region_name="PH_PKB"
                     /note="Protein Kinase B-like pleckstrin homology (PH)
                     domain; cd01241"
                     /db_xref="CDD:269947"
     Site            order(14,16..19,23,25,52..53,55,86)
                     /site_type="other"
                     /note="phosphoinositide binding site [chemical binding]"
                     /db_xref="CDD:269947"
     Region          124..479
                     /region_name="STKc_PKB_alpha"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     Protein Kinase B alpha (also called Akt1); cd05594"
                     /db_xref="CDD:270746"
     Site            order(156..157,159..160,164,177,179,191,194,211,227..230,
                     234,236,240,274,276,278..279,281,291..292,295,309..316,
                     341,347,350,438,442)
                     /site_type="active"
                     /db_xref="CDD:270746"
     Site            order(156..157,159,164,177,179,211,227..230,234,274,276,
                     278..279,281,291..292,438)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270746"
     Site            order(160,191,194,234,236,240,274,276,278,295,309..316,
                     341,347,350,442)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270746"
     Site            291..314
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270746"
     Site            450
                     /site_type="other"
                     /note="turn motif phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:270746"
     Site            469..474
                     /site_type="other"
                     /note="hydrophobic motif (HM)"
                     /db_xref="CDD:270746"
     CDS             1..480
                     /gene="AKT1"
                     /gene_synonym="AKT; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA"
                     /coded_by="XM_047431072.1:832..2274"
                     /db_xref="GeneID:207"
                     /db_xref="HGNC:HGNC:391"
                     /db_xref="MIM:164730"
ORIGIN      
        1 msdvaivkeg wlhkrgeyik twrpryfllk ndgtfigyke rpqdvdqrea plnnfsvaqc
       61 qlmkterprp ntfiirclqw ttviertfhv etpeereewt taiqtvadgl kkqeeeemdf
      121 rsgspsdnsg aeemevslak pkhrvtmnef eylkllgkgt fgkvilvkek atgryyamki
      181 lkkevivakd evahtltenr vlqnsrhpfl talkysfqth drlcfvmeya nggelffhls
      241 rervfsedra rfygaeivsa ldylhseknv vyrdlklenl mldkdghiki tdfglckegi
      301 kdgatmktfc gtpeylapev ledndygrav dwwglgvvmy emmcgrlpfy nqdheklfel
      361 ilmeeirfpr tlgpeaksll sgllkkdpkq rlgggsedak eimqhrffag ivwqhvyekk
      421 lsppfkpqvt setdtryfde eftaqmitit ppdqddsmec vdserrphfp qfsysasgta
//
LOCUS       XP_047287029             480 aa            linear   PRI 05-AUG-2025
DEFINITION  RAC-alpha serine/threonine-protein kinase isoform X1 [Homo
            sapiens].
ACCESSION   XP_047287029
VERSION     XP_047287029.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431073.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..480
                     /product="RAC-alpha serine/threonine-protein kinase
                     isoform X1"
                     /calculated_mol_wt=55556
     Region          4..111
                     /region_name="PH_PKB"
                     /note="Protein Kinase B-like pleckstrin homology (PH)
                     domain; cd01241"
                     /db_xref="CDD:269947"
     Site            order(14,16..19,23,25,52..53,55,86)
                     /site_type="other"
                     /note="phosphoinositide binding site [chemical binding]"
                     /db_xref="CDD:269947"
     Region          124..479
                     /region_name="STKc_PKB_alpha"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     Protein Kinase B alpha (also called Akt1); cd05594"
                     /db_xref="CDD:270746"
     Site            order(156..157,159..160,164,177,179,191,194,211,227..230,
                     234,236,240,274,276,278..279,281,291..292,295,309..316,
                     341,347,350,438,442)
                     /site_type="active"
                     /db_xref="CDD:270746"
     Site            order(156..157,159,164,177,179,211,227..230,234,274,276,
                     278..279,281,291..292,438)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270746"
     Site            order(160,191,194,234,236,240,274,276,278,295,309..316,
                     341,347,350,442)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270746"
     Site            291..314
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270746"
     Site            450
                     /site_type="other"
                     /note="turn motif phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:270746"
     Site            469..474
                     /site_type="other"
                     /note="hydrophobic motif (HM)"
                     /db_xref="CDD:270746"
     CDS             1..480
                     /gene="AKT1"
                     /gene_synonym="AKT; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA"
                     /coded_by="XM_047431073.1:1244..2686"
                     /db_xref="GeneID:207"
                     /db_xref="HGNC:HGNC:391"
                     /db_xref="MIM:164730"
ORIGIN      
        1 msdvaivkeg wlhkrgeyik twrpryfllk ndgtfigyke rpqdvdqrea plnnfsvaqc
       61 qlmkterprp ntfiirclqw ttviertfhv etpeereewt taiqtvadgl kkqeeeemdf
      121 rsgspsdnsg aeemevslak pkhrvtmnef eylkllgkgt fgkvilvkek atgryyamki
      181 lkkevivakd evahtltenr vlqnsrhpfl talkysfqth drlcfvmeya nggelffhls
      241 rervfsedra rfygaeivsa ldylhseknv vyrdlklenl mldkdghiki tdfglckegi
      301 kdgatmktfc gtpeylapev ledndygrav dwwglgvvmy emmcgrlpfy nqdheklfel
      361 ilmeeirfpr tlgpeaksll sgllkkdpkq rlgggsedak eimqhrffag ivwqhvyekk
      421 lsppfkpqvt setdtryfde eftaqmitit ppdqddsmec vdserrphfp qfsysasgta
//
LOCUS       XP_047287030             480 aa            linear   PRI 05-AUG-2025
DEFINITION  RAC-alpha serine/threonine-protein kinase isoform X1 [Homo
            sapiens].
ACCESSION   XP_047287030
VERSION     XP_047287030.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431074.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 15% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..480
                     /product="RAC-alpha serine/threonine-protein kinase
                     isoform X1"
                     /calculated_mol_wt=55556
     Region          4..111
                     /region_name="PH_PKB"
                     /note="Protein Kinase B-like pleckstrin homology (PH)
                     domain; cd01241"
                     /db_xref="CDD:269947"
     Site            order(14,16..19,23,25,52..53,55,86)
                     /site_type="other"
                     /note="phosphoinositide binding site [chemical binding]"
                     /db_xref="CDD:269947"
     Region          124..479
                     /region_name="STKc_PKB_alpha"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     Protein Kinase B alpha (also called Akt1); cd05594"
                     /db_xref="CDD:270746"
     Site            order(156..157,159..160,164,177,179,191,194,211,227..230,
                     234,236,240,274,276,278..279,281,291..292,295,309..316,
                     341,347,350,438,442)
                     /site_type="active"
                     /db_xref="CDD:270746"
     Site            order(156..157,159,164,177,179,211,227..230,234,274,276,
                     278..279,281,291..292,438)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270746"
     Site            order(160,191,194,234,236,240,274,276,278,295,309..316,
                     341,347,350,442)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270746"
     Site            291..314
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270746"
     Site            450
                     /site_type="other"
                     /note="turn motif phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:270746"
     Site            469..474
                     /site_type="other"
                     /note="hydrophobic motif (HM)"
                     /db_xref="CDD:270746"
     CDS             1..480
                     /gene="AKT1"
                     /gene_synonym="AKT; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA"
                     /coded_by="XM_047431074.1:1480..2922"
                     /db_xref="GeneID:207"
                     /db_xref="HGNC:HGNC:391"
                     /db_xref="MIM:164730"
ORIGIN      
        1 msdvaivkeg wlhkrgeyik twrpryfllk ndgtfigyke rpqdvdqrea plnnfsvaqc
       61 qlmkterprp ntfiirclqw ttviertfhv etpeereewt taiqtvadgl kkqeeeemdf
      121 rsgspsdnsg aeemevslak pkhrvtmnef eylkllgkgt fgkvilvkek atgryyamki
      181 lkkevivakd evahtltenr vlqnsrhpfl talkysfqth drlcfvmeya nggelffhls
      241 rervfsedra rfygaeivsa ldylhseknv vyrdlklenl mldkdghiki tdfglckegi
      301 kdgatmktfc gtpeylapev ledndygrav dwwglgvvmy emmcgrlpfy nqdheklfel
      361 ilmeeirfpr tlgpeaksll sgllkkdpkq rlgggsedak eimqhrffag ivwqhvyekk
      421 lsppfkpqvt setdtryfde eftaqmitit ppdqddsmec vdserrphfp qfsysasgta
//
LOCUS       XP_047287031             480 aa            linear   PRI 05-AUG-2025
DEFINITION  RAC-alpha serine/threonine-protein kinase isoform X1 [Homo
            sapiens].
ACCESSION   XP_047287031
VERSION     XP_047287031.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431075.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 12% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..480
                     /product="RAC-alpha serine/threonine-protein kinase
                     isoform X1"
                     /calculated_mol_wt=55556
     Region          4..111
                     /region_name="PH_PKB"
                     /note="Protein Kinase B-like pleckstrin homology (PH)
                     domain; cd01241"
                     /db_xref="CDD:269947"
     Site            order(14,16..19,23,25,52..53,55,86)
                     /site_type="other"
                     /note="phosphoinositide binding site [chemical binding]"
                     /db_xref="CDD:269947"
     Region          124..479
                     /region_name="STKc_PKB_alpha"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     Protein Kinase B alpha (also called Akt1); cd05594"
                     /db_xref="CDD:270746"
     Site            order(156..157,159..160,164,177,179,191,194,211,227..230,
                     234,236,240,274,276,278..279,281,291..292,295,309..316,
                     341,347,350,438,442)
                     /site_type="active"
                     /db_xref="CDD:270746"
     Site            order(156..157,159,164,177,179,211,227..230,234,274,276,
                     278..279,281,291..292,438)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270746"
     Site            order(160,191,194,234,236,240,274,276,278,295,309..316,
                     341,347,350,442)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270746"
     Site            291..314
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270746"
     Site            450
                     /site_type="other"
                     /note="turn motif phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:270746"
     Site            469..474
                     /site_type="other"
                     /note="hydrophobic motif (HM)"
                     /db_xref="CDD:270746"
     CDS             1..480
                     /gene="AKT1"
                     /gene_synonym="AKT; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA"
                     /coded_by="XM_047431075.1:666..2108"
                     /db_xref="GeneID:207"
                     /db_xref="HGNC:HGNC:391"
                     /db_xref="MIM:164730"
ORIGIN      
        1 msdvaivkeg wlhkrgeyik twrpryfllk ndgtfigyke rpqdvdqrea plnnfsvaqc
       61 qlmkterprp ntfiirclqw ttviertfhv etpeereewt taiqtvadgl kkqeeeemdf
      121 rsgspsdnsg aeemevslak pkhrvtmnef eylkllgkgt fgkvilvkek atgryyamki
      181 lkkevivakd evahtltenr vlqnsrhpfl talkysfqth drlcfvmeya nggelffhls
      241 rervfsedra rfygaeivsa ldylhseknv vyrdlklenl mldkdghiki tdfglckegi
      301 kdgatmktfc gtpeylapev ledndygrav dwwglgvvmy emmcgrlpfy nqdheklfel
      361 ilmeeirfpr tlgpeaksll sgllkkdpkq rlgggsedak eimqhrffag ivwqhvyekk
      421 lsppfkpqvt setdtryfde eftaqmitit ppdqddsmec vdserrphfp qfsysasgta
//
LOCUS       XP_047287032             481 aa            linear   PRI 05-AUG-2025
DEFINITION  estrogen receptor beta isoform X1 [Homo sapiens].
ACCESSION   XP_047287032
VERSION     XP_047287032.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431076.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..481
                     /product="estrogen receptor beta isoform X1"
                     /calculated_mol_wt=53965
     Region          16..125
                     /region_name="ERbeta_N"
                     /note="Estrogen receptor beta; pfam12497"
                     /db_xref="CDD:463610"
     Region          144..225
                     /region_name="NR_DBD_ER"
                     /note="DNA-binding domain of estrogen receptors (ER) is
                     composed of two C4-type zinc fingers; cd07171"
                     /db_xref="CDD:143545"
     Site            order(149,152,166,169,185,191,201,204)
                     /site_type="other"
                     /note="zinc binding site [ion binding]"
                     /db_xref="CDD:143545"
     Site            order(158..161,167..168,170..172,174..175,198..199,202,
                     205)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143545"
     Site            order(184..187,191..192,197,200)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:143545"
     Region          263..468
                     /region_name="NR_LBD_ER"
                     /note="Ligand binding domain of Estrogen receptor, which
                     are activated by the hormone 17beta-estradiol (estrogen);
                     cd06949"
                     /db_xref="CDD:132747"
     Site            order(403,407,409..410,430,434..435,438,452..453,455..457,
                     459..460,463..464,466..467)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:132747"
     CDS             1..481
                     /gene="ESR2"
                     /gene_synonym="ER-BETA; Erb; ESR-BETA; ESRB; ESTRB; NR3A2;
                     ODG8"
                     /coded_by="XM_047431076.1:1115..2560"
                     /db_xref="GeneID:2100"
                     /db_xref="HGNC:HGNC:3468"
                     /db_xref="MIM:601663"
ORIGIN      
        1 mdiknspssl nspssyncsq silplehgsi yipssyvdsh heypamtfys pavmnysips
       61 nvtnleggpg rqttspnvlw ptpghlsplv vhrqlshlya epqkspwcea rslehtlpvn
      121 retlkrkvsg nrcaspvtgp gskrdahfca vcsdyasgyh ygvwscegck affkrsiqgh
      181 ndyicpatnq ctidknrrks cqacrlrkcy evgmvkcgsr rercgyrlvr rqrsadeqlh
      241 cagkakrsgg haprvrelll dalspeqlvl tlleaepphv lisrpsapft easmmmsltk
      301 ladkelvhmi swakkipgfv elslfdqvrl lescwmevlm mglmwrsidh pgklifapdl
      361 vldrdegkcv egileifdml lattsrfrel klqhkeylcv kamillnssm yplvtatqda
      421 dssrklahll navtdalvwv iaksgissqq qsmrlanllm llshvrharw gekqfihlkl
      481 s
//
LOCUS       XP_047287033             474 aa            linear   PRI 05-AUG-2025
DEFINITION  estrogen receptor beta isoform X2 [Homo sapiens].
ACCESSION   XP_047287033
VERSION     XP_047287033.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431077.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..474
                     /product="estrogen receptor beta isoform X2"
                     /calculated_mol_wt=53078
     Region          16..125
                     /region_name="ERbeta_N"
                     /note="Estrogen receptor beta; pfam12497"
                     /db_xref="CDD:463610"
     Region          144..225
                     /region_name="NR_DBD_ER"
                     /note="DNA-binding domain of estrogen receptors (ER) is
                     composed of two C4-type zinc fingers; cd07171"
                     /db_xref="CDD:143545"
     Site            order(149,152,166,169,185,191,201,204)
                     /site_type="other"
                     /note="zinc binding site [ion binding]"
                     /db_xref="CDD:143545"
     Site            order(158..161,167..168,170..172,174..175,198..199,202,
                     205)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143545"
     Site            order(184..187,191..192,197,200)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:143545"
     Region          263..470
                     /region_name="NR_LBD_ER"
                     /note="Ligand binding domain of Estrogen receptor, which
                     are activated by the hormone 17beta-estradiol (estrogen);
                     cd06949"
                     /db_xref="CDD:132747"
     Site            order(403,407,409..410,430,434..435,438,452..453,455..457,
                     459..460,463..464,466..467,470)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:132747"
     CDS             1..474
                     /gene="ESR2"
                     /gene_synonym="ER-BETA; Erb; ESR-BETA; ESRB; ESTRB; NR3A2;
                     ODG8"
                     /coded_by="XM_047431077.1:1115..2539"
                     /db_xref="GeneID:2100"
                     /db_xref="HGNC:HGNC:3468"
                     /db_xref="MIM:601663"
ORIGIN      
        1 mdiknspssl nspssyncsq silplehgsi yipssyvdsh heypamtfys pavmnysips
       61 nvtnleggpg rqttspnvlw ptpghlsplv vhrqlshlya epqkspwcea rslehtlpvn
      121 retlkrkvsg nrcaspvtgp gskrdahfca vcsdyasgyh ygvwscegck affkrsiqgh
      181 ndyicpatnq ctidknrrks cqacrlrkcy evgmvkcgsr rercgyrlvr rqrsadeqlh
      241 cagkakrsgg haprvrelll dalspeqlvl tlleaepphv lisrpsapft easmmmsltk
      301 ladkelvhmi swakkipgfv elslfdqvrl lescwmevlm mglmwrsidh pgklifapdl
      361 vldrdegkcv egileifdml lattsrfrel klqhkeylcv kamillnssm yplvtatqda
      421 dssrklahll navtdalvwv iaksgissqq qsmrlanllm llshvrhars cvyk
//
LOCUS       XP_047287034             323 aa            linear   PRI 05-AUG-2025
DEFINITION  estrogen receptor beta isoform X3 [Homo sapiens].
ACCESSION   XP_047287034
VERSION     XP_047287034.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431078.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..323
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..323
                     /product="estrogen receptor beta isoform X3"
                     /calculated_mol_wt=35813
     Region          16..125
                     /region_name="ERbeta_N"
                     /note="Estrogen receptor beta; pfam12497"
                     /db_xref="CDD:463610"
     Region          144..225
                     /region_name="NR_DBD_ER"
                     /note="DNA-binding domain of estrogen receptors (ER) is
                     composed of two C4-type zinc fingers; cd07171"
                     /db_xref="CDD:143545"
     Site            order(149,152,166,169,185,191,201,204)
                     /site_type="other"
                     /note="zinc binding site [ion binding]"
                     /db_xref="CDD:143545"
     Site            order(158..161,167..168,170..172,174..175,198..199,202,
                     205)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143545"
     Site            order(184..187,191..192,197,200)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:143545"
     Region          263..>318
                     /region_name="NR_LBD"
                     /note="The ligand binding domain of nuclear receptors, a
                     family of ligand-activated transcription regulators;
                     cl11397"
                     /db_xref="CDD:472173"
     CDS             1..323
                     /gene="ESR2"
                     /gene_synonym="ER-BETA; Erb; ESR-BETA; ESRB; ESTRB; NR3A2;
                     ODG8"
                     /coded_by="XM_047431078.1:1115..2086"
                     /db_xref="GeneID:2100"
                     /db_xref="HGNC:HGNC:3468"
                     /db_xref="MIM:601663"
ORIGIN      
        1 mdiknspssl nspssyncsq silplehgsi yipssyvdsh heypamtfys pavmnysips
       61 nvtnleggpg rqttspnvlw ptpghlsplv vhrqlshlya epqkspwcea rslehtlpvn
      121 retlkrkvsg nrcaspvtgp gskrdahfca vcsdyasgyh ygvwscegck affkrsiqgh
      181 ndyicpatnq ctidknrrks cqacrlrkcy evgmvkcgsr rercgyrlvr rqrsadeqlh
      241 cagkakrsgg haprvrelll dalspeqlvl tlleaepphv lisrpsapft easmmmsltk
      301 ladkelvhmi swakkipgmr gna
//
LOCUS       XP_011534849             573 aa            linear   PRI 05-AUG-2025
DEFINITION  steroid hormone receptor ERR2 isoform X1 [Homo sapiens].
ACCESSION   XP_011534849
VERSION     XP_011534849.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536547.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..573
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..573
                     /product="steroid hormone receptor ERR2 isoform X1"
                     /calculated_mol_wt=63315
     Region          119..214
                     /region_name="NR_DBD_ERR"
                     /note="DNA-binding domain of estrogen related receptors
                     (ERR) is composed of two C4-type zinc fingers; cd07170"
                     /db_xref="CDD:143544"
     Site            order(122,134..137,142..143,145..147,149..150,153,
                     173..174,177,180,194..195,198..205)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143544"
     Site            order(124,127,141,144,160,166,176,179)
                     /site_type="other"
                     /note="zinc binding site [ion binding]"
                     /db_xref="CDD:143544"
     Region          233..452
                     /region_name="NR_LBD_ERR"
                     /note="The ligand binding domain of estrogen
                     receptor-related nuclear receptors; cd06946"
                     /db_xref="CDD:132744"
     Site            order(261,264,268,271,309,322,326,336..338,431,434,436)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:132744"
     Site            order(276,290,293..294,297..298,444..445,448..449)
                     /site_type="other"
                     /note="coactivator recognition site [polypeptide binding]"
                     /db_xref="CDD:132744"
     Site            372
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:132744"
     CDS             1..573
                     /gene="ESRRB"
                     /gene_synonym="DFNB35; ERR beta-2; ERR2; ERRb; ERRbeta2;
                     ESRL2; NR3B2"
                     /coded_by="XM_011536547.3:266..1987"
                     /db_xref="GeneID:2103"
                     /db_xref="HGNC:HGNC:3473"
                     /db_xref="MIM:602167"
ORIGIN      
        1 mdvselcipd plgyhnqlln rmssddrhlg sscgsfikte psspssgida lshhspsgss
       61 dasggfglal gthangldsp pmfagaglgg tpcrksyedc asgimedsai kceymlnaip
      121 krlclvcgdi asgyhygvas ceackaffkr tiqgnieysc patneceitk rrrkscqacr
      181 fmkclkvgml kegvrldrvr ggrqkykrrl dsesspylsl qisppakkpl tkivsyllva
      241 epdklyampp pgmpegdika lttlcdladr elvviigwak hipgfsslsl gdqmsllqsa
      301 wmeililgiv yrslpyddkl vyaedyimde ehsrlaglle lyrailqlvr rykklkveke
      361 efvtlkalal ansdsmyied leavqklqdl lhealqdyel sqrheepwrt gkllltlpll
      421 rqtaakavqh fysvklqgkv pmhklfleml eakvgqeqlr gspkdermss hdgkcpfqsa
      481 aftsrdqsns pgipnprpss ptplnergrq ispstrtpgg qvtfcsfsie alvpppwlyp
      541 rnlpawasgl graevipdrr egwlkstncr aal
//
LOCUS       XP_047287035             552 aa            linear   PRI 05-AUG-2025
DEFINITION  steroid hormone receptor ERR2 isoform X2 [Homo sapiens].
ACCESSION   XP_047287035
VERSION     XP_047287035.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431079.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..552
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..552
                     /product="steroid hormone receptor ERR2 isoform X2"
                     /calculated_mol_wt=60905
     Region          98..193
                     /region_name="NR_DBD_ERR"
                     /note="DNA-binding domain of estrogen related receptors
                     (ERR) is composed of two C4-type zinc fingers; cd07170"
                     /db_xref="CDD:143544"
     Site            order(101,113..116,121..122,124..126,128..129,132,
                     152..153,156,159,173..174,177..184)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143544"
     Site            order(103,106,120,123,139,145,155,158)
                     /site_type="other"
                     /note="zinc binding site [ion binding]"
                     /db_xref="CDD:143544"
     Region          212..431
                     /region_name="NR_LBD_ERR"
                     /note="The ligand binding domain of estrogen
                     receptor-related nuclear receptors; cd06946"
                     /db_xref="CDD:132744"
     Site            order(240,243,247,250,288,301,305,315..317,410,413,415)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:132744"
     Site            order(255,269,272..273,276..277,423..424,427..428)
                     /site_type="other"
                     /note="coactivator recognition site [polypeptide binding]"
                     /db_xref="CDD:132744"
     Site            351
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:132744"
     CDS             1..552
                     /gene="ESRRB"
                     /gene_synonym="DFNB35; ERR beta-2; ERR2; ERRb; ERRbeta2;
                     ESRL2; NR3B2"
                     /coded_by="XM_047431079.1:208..1866"
                     /db_xref="GeneID:2103"
                     /db_xref="HGNC:HGNC:3473"
                     /db_xref="MIM:602167"
ORIGIN      
        1 mssddrhlgs scgsfiktep sspssgidal shhspsgssd asggfglalg thangldspp
       61 mfagaglggt pcrksyedca sgimedsaik ceymlnaipk rlclvcgdia sgyhygvasc
      121 eackaffkrt iqgnieyscp atneceitkr rrkscqacrf mkclkvgmlk egvrldrvrg
      181 grqkykrrld sesspylslq isppakkplt kivsyllvae pdklyamppp gmpegdikal
      241 ttlcdladre lvviigwakh ipgfsslslg dqmsllqsaw meililgivy rslpyddklv
      301 yaedyimdee hsrlagllel yrailqlvrr ykklkvekee fvtlkalala nsdsmyiedl
      361 eavqklqdll healqdyels qrheepwrtg kllltlpllr qtaakavqhf ysvklqgkvp
      421 mhklflemle akvgqeqlrg spkdermssh dgkcpfqsaa ftsrdqsnsp gipnprpssp
      481 tplnergrqi spstrtpggq vtfcsfsiea lvpppwlypr nlpawasglg raevipdrre
      541 gwlkstncra al
//
LOCUS       XP_011534852             552 aa            linear   PRI 05-AUG-2025
DEFINITION  steroid hormone receptor ERR2 isoform X2 [Homo sapiens].
ACCESSION   XP_011534852
VERSION     XP_011534852.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536550.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..552
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..552
                     /product="steroid hormone receptor ERR2 isoform X2"
                     /calculated_mol_wt=60905
     Region          98..193
                     /region_name="NR_DBD_ERR"
                     /note="DNA-binding domain of estrogen related receptors
                     (ERR) is composed of two C4-type zinc fingers; cd07170"
                     /db_xref="CDD:143544"
     Site            order(101,113..116,121..122,124..126,128..129,132,
                     152..153,156,159,173..174,177..184)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143544"
     Site            order(103,106,120,123,139,145,155,158)
                     /site_type="other"
                     /note="zinc binding site [ion binding]"
                     /db_xref="CDD:143544"
     Region          212..431
                     /region_name="NR_LBD_ERR"
                     /note="The ligand binding domain of estrogen
                     receptor-related nuclear receptors; cd06946"
                     /db_xref="CDD:132744"
     Site            order(240,243,247,250,288,301,305,315..317,410,413,415)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:132744"
     Site            order(255,269,272..273,276..277,423..424,427..428)
                     /site_type="other"
                     /note="coactivator recognition site [polypeptide binding]"
                     /db_xref="CDD:132744"
     Site            351
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:132744"
     CDS             1..552
                     /gene="ESRRB"
                     /gene_synonym="DFNB35; ERR beta-2; ERR2; ERRb; ERRbeta2;
                     ESRL2; NR3B2"
                     /coded_by="XM_011536550.3:602..2260"
                     /db_xref="GeneID:2103"
                     /db_xref="HGNC:HGNC:3473"
                     /db_xref="MIM:602167"
ORIGIN      
        1 mssddrhlgs scgsfiktep sspssgidal shhspsgssd asggfglalg thangldspp
       61 mfagaglggt pcrksyedca sgimedsaik ceymlnaipk rlclvcgdia sgyhygvasc
      121 eackaffkrt iqgnieyscp atneceitkr rrkscqacrf mkclkvgmlk egvrldrvrg
      181 grqkykrrld sesspylslq isppakkplt kivsyllvae pdklyamppp gmpegdikal
      241 ttlcdladre lvviigwakh ipgfsslslg dqmsllqsaw meililgivy rslpyddklv
      301 yaedyimdee hsrlagllel yrailqlvrr ykklkvekee fvtlkalala nsdsmyiedl
      361 eavqklqdll healqdyels qrheepwrtg kllltlpllr qtaakavqhf ysvklqgkvp
      421 mhklflemle akvgqeqlrg spkdermssh dgkcpfqsaa ftsrdqsnsp gipnprpssp
      481 tplnergrqi spstrtpggq vtfcsfsiea lvpppwlypr nlpawasglg raevipdrre
      541 gwlkstncra al
//
LOCUS       XP_011534855             531 aa            linear   PRI 05-AUG-2025
DEFINITION  steroid hormone receptor ERR2 isoform X3 [Homo sapiens].
ACCESSION   XP_011534855
VERSION     XP_011534855.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536553.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..531
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..531
                     /product="steroid hormone receptor ERR2 isoform X3"
                     /calculated_mol_wt=59047
     Region          119..214
                     /region_name="NR_DBD_ERR"
                     /note="DNA-binding domain of estrogen related receptors
                     (ERR) is composed of two C4-type zinc fingers; cd07170"
                     /db_xref="CDD:143544"
     Site            order(122,134..137,142..143,145..147,149..150,153,
                     173..174,177,180,194..195,198..205)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143544"
     Site            order(124,127,141,144,160,166,176,179)
                     /site_type="other"
                     /note="zinc binding site [ion binding]"
                     /db_xref="CDD:143544"
     Region          233..452
                     /region_name="NR_LBD_ERR"
                     /note="The ligand binding domain of estrogen
                     receptor-related nuclear receptors; cd06946"
                     /db_xref="CDD:132744"
     Site            order(261,264,268,271,309,322,326,336..338,431,434,436)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:132744"
     Site            order(276,290,293..294,297..298,444..445,448..449)
                     /site_type="other"
                     /note="coactivator recognition site [polypeptide binding]"
                     /db_xref="CDD:132744"
     Site            372
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:132744"
     CDS             1..531
                     /gene="ESRRB"
                     /gene_synonym="DFNB35; ERR beta-2; ERR2; ERRb; ERRbeta2;
                     ESRL2; NR3B2"
                     /coded_by="XM_011536553.3:266..1861"
                     /db_xref="GeneID:2103"
                     /db_xref="HGNC:HGNC:3473"
                     /db_xref="MIM:602167"
ORIGIN      
        1 mdvselcipd plgyhnqlln rmssddrhlg sscgsfikte psspssgida lshhspsgss
       61 dasggfglal gthangldsp pmfagaglgg tpcrksyedc asgimedsai kceymlnaip
      121 krlclvcgdi asgyhygvas ceackaffkr tiqgnieysc patneceitk rrrkscqacr
      181 fmkclkvgml kegvrldrvr ggrqkykrrl dsesspylsl qisppakkpl tkivsyllva
      241 epdklyampp pgmpegdika lttlcdladr elvviigwak hipgfsslsl gdqmsllqsa
      301 wmeililgiv yrslpyddkl vyaedyimde ehsrlaglle lyrailqlvr rykklkveke
      361 efvtlkalal ansdsmyied leavqklqdl lhealqdyel sqrheepwrt gkllltlpll
      421 rqtaakavqh fysvklqgkv pmhklfleml eakawarads lqewrpleqv psplhratkr
      481 qhvhfltplp pppsvawvgt aqagyhlevf lpqragtqgt tvsffqrsyl l
//
LOCUS       XP_011534856             529 aa            linear   PRI 05-AUG-2025
DEFINITION  steroid hormone receptor ERR2 isoform X4 [Homo sapiens].
ACCESSION   XP_011534856
VERSION     XP_011534856.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536554.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..529
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..529
                     /product="steroid hormone receptor ERR2 isoform X4"
                     /calculated_mol_wt=58487
     Region          119..214
                     /region_name="NR_DBD_ERR"
                     /note="DNA-binding domain of estrogen related receptors
                     (ERR) is composed of two C4-type zinc fingers; cd07170"
                     /db_xref="CDD:143544"
     Site            order(122,134..137,142..143,145..147,149..150,153,
                     173..174,177,180,194..195,198..205)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143544"
     Site            order(124,127,141,144,160,166,176,179)
                     /site_type="other"
                     /note="zinc binding site [ion binding]"
                     /db_xref="CDD:143544"
     Region          233..452
                     /region_name="NR_LBD_ERR"
                     /note="The ligand binding domain of estrogen
                     receptor-related nuclear receptors; cd06946"
                     /db_xref="CDD:132744"
     Site            order(261,264,268,271,309,322,326,336..338,431,434,436)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:132744"
     Site            order(276,290,293..294,297..298,444..445,448..449)
                     /site_type="other"
                     /note="coactivator recognition site [polypeptide binding]"
                     /db_xref="CDD:132744"
     Site            372
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:132744"
     CDS             1..529
                     /gene="ESRRB"
                     /gene_synonym="DFNB35; ERR beta-2; ERR2; ERRb; ERRbeta2;
                     ESRL2; NR3B2"
                     /coded_by="XM_011536554.3:266..1855"
                     /db_xref="GeneID:2103"
                     /db_xref="HGNC:HGNC:3473"
                     /db_xref="MIM:602167"
ORIGIN      
        1 mdvselcipd plgyhnqlln rmssddrhlg sscgsfikte psspssgida lshhspsgss
       61 dasggfglal gthangldsp pmfagaglgg tpcrksyedc asgimedsai kceymlnaip
      121 krlclvcgdi asgyhygvas ceackaffkr tiqgnieysc patneceitk rrrkscqacr
      181 fmkclkvgml kegvrldrvr ggrqkykrrl dsesspylsl qisppakkpl tkivsyllva
      241 epdklyampp pgmpegdika lttlcdladr elvviigwak hipgfsslsl gdqmsllqsa
      301 wmeililgiv yrslpyddkl vyaedyimde ehsrlaglle lyrailqlvr rykklkveke
      361 efvtlkalal ansdsmyied leavqklqdl lhealqdyel sqrheepwrt gkllltlpll
      421 rqtaakavqh fysvklqgkv pmhklfleml eakvgqeqlr gspkdermss hdgkcpfqsa
      481 aftsrdqsns pgipnprpss ptplnergrq ispstrtpgg qgkhlwltm
//
LOCUS       XP_024305276             521 aa            linear   PRI 05-AUG-2025
DEFINITION  steroid hormone receptor ERR2 isoform X5 [Homo sapiens].
ACCESSION   XP_024305276
VERSION     XP_024305276.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449508.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..521
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..521
                     /product="steroid hormone receptor ERR2 isoform X5"
                     /calculated_mol_wt=57898
     Region          119..214
                     /region_name="NR_DBD_ERR"
                     /note="DNA-binding domain of estrogen related receptors
                     (ERR) is composed of two C4-type zinc fingers; cd07170"
                     /db_xref="CDD:143544"
     Site            order(122,134..137,142..143,145..147,149..150,153,
                     173..174,177,180,194..195,198..205)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143544"
     Site            order(124,127,141,144,160,166,176,179)
                     /site_type="other"
                     /note="zinc binding site [ion binding]"
                     /db_xref="CDD:143544"
     Region          233..452
                     /region_name="NR_LBD_ERR"
                     /note="The ligand binding domain of estrogen
                     receptor-related nuclear receptors; cd06946"
                     /db_xref="CDD:132744"
     Site            order(261,264,268,271,309,322,326,336..338,431,434,436)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:132744"
     Site            order(276,290,293..294,297..298,444..445,448..449)
                     /site_type="other"
                     /note="coactivator recognition site [polypeptide binding]"
                     /db_xref="CDD:132744"
     Site            372
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:132744"
     CDS             1..521
                     /gene="ESRRB"
                     /gene_synonym="DFNB35; ERR beta-2; ERR2; ERRb; ERRbeta2;
                     ESRL2; NR3B2"
                     /coded_by="XM_024449508.2:266..1831"
                     /db_xref="GeneID:2103"
                     /db_xref="HGNC:HGNC:3473"
                     /db_xref="MIM:602167"
ORIGIN      
        1 mdvselcipd plgyhnqlln rmssddrhlg sscgsfikte psspssgida lshhspsgss
       61 dasggfglal gthangldsp pmfagaglgg tpcrksyedc asgimedsai kceymlnaip
      121 krlclvcgdi asgyhygvas ceackaffkr tiqgnieysc patneceitk rrrkscqacr
      181 fmkclkvgml kegvrldrvr ggrqkykrrl dsesspylsl qisppakkpl tkivsyllva
      241 epdklyampp pgmpegdika lttlcdladr elvviigwak hipgfsslsl gdqmsllqsa
      301 wmeililgiv yrslpyddkl vyaedyimde ehsrlaglle lyrailqlvr rykklkveke
      361 efvtlkalal ansdsmyied leavqklqdl lhealqdyel sqrheepwrt gkllltlpll
      421 rqtaakavqh fysvklqgkv pmhklfleml eakawarads lqewrpleqv psplhratkr
      481 qhvhfltplp pppsvawvgt aqagyhlevf lpqragwpra a
//
LOCUS       XP_005267462            1402 aa            linear   PRI 05-AUG-2025
DEFINITION  nidogen-2 isoform X1 [Homo sapiens].
ACCESSION   XP_005267462
VERSION     XP_005267462.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267405.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1402
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1402
                     /product="nidogen-2 isoform X1"
                     /calculated_mol_wt=154164
     Region          108..273
                     /region_name="NIDO"
                     /note="Extracellular domain of unknown function in nidogen
                     (entactin) and hypothetical proteins; smart00539"
                     /db_xref="CDD:214712"
     Region          515..550
                     /region_name="EGF_3"
                     /note="EGF domain; pfam12947"
                     /db_xref="CDD:463759"
     Region          552..784
                     /region_name="G2F"
                     /note="G2 nidogen domain and fibulin; smart00682"
                     /db_xref="CDD:214774"
     Site            order(558,582,584,591,593,595,759,764,768,770)
                     /site_type="other"
                     /note="collagen/perlecan interaction surface [polypeptide
                     binding]"
                     /db_xref="CDD:238158"
     Region          790..826
                     /region_name="EGF_3"
                     /note="EGF domain; pfam12947"
                     /db_xref="CDD:463759"
     Region          828..870
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain; smart00179"
                     /db_xref="CDD:214542"
     Site            order(828,831,847)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          879..917
                     /region_name="EGF_3"
                     /note="EGF domain; pfam12947"
                     /db_xref="CDD:463759"
     Region          923..956
                     /region_name="EGF_3"
                     /note="EGF domain; pfam12947"
                     /db_xref="CDD:463759"
     Region          966..1032
                     /region_name="TY"
                     /note="Thyroglobulin type I repeats.; The N-terminal
                     region of human thyroglobulin contains 11 type-1 repeats
                     TY repeats are proposed to be inhibitors of cysteine
                     proteases; cd00191"
                     /db_xref="CDD:238114"
     Site            order(971,985,1003,1007)
                     /site_type="active"
                     /note="protease interaction site [active]"
                     /db_xref="CDD:238114"
     Region          1046..1111
                     /region_name="TY"
                     /note="Thyroglobulin type I repeats.; The N-terminal
                     region of human thyroglobulin contains 11 type-1 repeats
                     TY repeats are proposed to be inhibitors of cysteine
                     proteases; cd00191"
                     /db_xref="CDD:238114"
     Site            order(1050,1065,1083,1087)
                     /site_type="active"
                     /note="protease interaction site [active]"
                     /db_xref="CDD:238114"
     Region          1161..1199
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          1205..1247
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          1248..1292
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          1293..1335
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     CDS             1..1402
                     /gene="NID2"
                     /gene_synonym="NID-2"
                     /coded_by="XM_005267405.5:66..4274"
                     /db_xref="GeneID:22795"
                     /db_xref="HGNC:HGNC:13389"
                     /db_xref="MIM:605399"
ORIGIN      
        1 megdrvagrp vlsslpvlll lpllmlraaa lhpdelfphg eswgdqllqe gddessavvk
       61 lanplhfyea rfsnlyvgtn giistqdfpr etqyvdydfp tdfpaiapfl adidtshgrg
      121 rvlyredtsp avlglaaryv ragfprsarf tpthaflatw eqvgayeevk rgalpsgeln
      181 tfqavlasdg sdsyalflyp anglqflgtr pkesynvqlq lparvgfcrg eaddlksegp
      241 yfsltsteqs vknlyqlsnl gipgvwafhi gstspldnvr paavgdlsaa hssvplgrsf
      301 shatalesdy nednldyydv neeeaeylpg epeealnghs sidvsfqskv dtkplegris
      361 ppdsdlsspl hptptywpfy petesstldp htkegtslge vggpdlkgqv epwderetrs
      421 pappevdrds lapswetppp ypengsiqpy pdggpvpsem dvppahpeee ivlrsypasg
      481 httplsrgty evglednigs ntevftynaa nketcehnhr qcsrhafctd yatgfcchcq
      541 skfygngkhc lpegaphrvn gkvsghlhvg htpvhftdvd lhayivgndg raytaiship
      601 qpaaqallpl tpigglfgwl falekpgsen gfslagaaft hdmevtfypg eetvritqta
      661 egldpenyls iktniqgqvp yvsanftahi spykelyhys dstvtstssr dysltfgain
      721 qtwsyrihqn ityqvcrhap rhpsfpttqq lnvdrvfaly ndeervlrfa vtnqigpvke
      781 dsdptpgnpc ydgshmcdtt archpgtgvd ytcecasgyq gdgrncvden ecatgfhrcg
      841 pnsvcinlpg syrcecrsgy efaddrhtci litppanpce dgshtcapag qarcvhhggs
      901 tfscaclpgy agdghqctdv decsenrchp aatcyntpgs fscrcqpgyy gdgfqcipds
      961 tssltpceqq qrhaqaqyay pgarfhipqc deqgnflplq chgstgfcwc vdpdghevpg
     1021 tqtppgstpp hcgpspeptq rppticerwr enllehyggt prddqyvpqc ddlghfiplq
     1081 chgksdfcwc vdkdgrevqg trsqpgttpa ciptvappmv rptprpdvtp psvgtfllyt
     1141 qgqqigylpl ngtrlqkdaa ktllslhgsi ivgidydcre rmvywtdvag rtisraglel
     1201 gaepetivns glispeglai dhirrtmywt dsvldkiesa lldgserkvl fytdlvnpra
     1261 iavdpirgnl ywtdwnreap kietssldge nrrilintdi glpngltfdp fskllcwada
     1321 gtkklectlp dgtgrrviqn nlkypfsivs yadhfyhtdw rrdgvvsvnk hsgqftdeyl
     1381 peqrshlygi tavypycptg rk
//
LOCUS       XP_005267463            1354 aa            linear   PRI 05-AUG-2025
DEFINITION  nidogen-2 isoform X2 [Homo sapiens].
ACCESSION   XP_005267463
VERSION     XP_005267463.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267406.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1354
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1354
                     /product="nidogen-2 isoform X2"
                     /calculated_mol_wt=149433
     Region          108..273
                     /region_name="NIDO"
                     /note="Extracellular domain of unknown function in nidogen
                     (entactin) and hypothetical proteins; smart00539"
                     /db_xref="CDD:214712"
     Region          515..550
                     /region_name="EGF_3"
                     /note="EGF domain; pfam12947"
                     /db_xref="CDD:463759"
     Region          552..784
                     /region_name="G2F"
                     /note="G2 nidogen domain and fibulin; smart00682"
                     /db_xref="CDD:214774"
     Site            order(558,582,584,591,593,595,759,764,768,770)
                     /site_type="other"
                     /note="collagen/perlecan interaction surface [polypeptide
                     binding]"
                     /db_xref="CDD:238158"
     Region          790..826
                     /region_name="EGF_3"
                     /note="EGF domain; pfam12947"
                     /db_xref="CDD:463759"
     Region          828..870
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain; smart00179"
                     /db_xref="CDD:214542"
     Site            order(828,831,847)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          875..908
                     /region_name="EGF_3"
                     /note="EGF domain; pfam12947"
                     /db_xref="CDD:463759"
     Region          918..984
                     /region_name="TY"
                     /note="Thyroglobulin type I repeats.; The N-terminal
                     region of human thyroglobulin contains 11 type-1 repeats
                     TY repeats are proposed to be inhibitors of cysteine
                     proteases; cd00191"
                     /db_xref="CDD:238114"
     Site            order(923,937,955,959)
                     /site_type="active"
                     /note="protease interaction site [active]"
                     /db_xref="CDD:238114"
     Region          998..1063
                     /region_name="TY"
                     /note="Thyroglobulin type I repeats.; The N-terminal
                     region of human thyroglobulin contains 11 type-1 repeats
                     TY repeats are proposed to be inhibitors of cysteine
                     proteases; cd00191"
                     /db_xref="CDD:238114"
     Site            order(1002,1017,1035,1039)
                     /site_type="active"
                     /note="protease interaction site [active]"
                     /db_xref="CDD:238114"
     Region          1113..1151
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          1157..1199
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          1200..1244
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          1245..1287
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     CDS             1..1354
                     /gene="NID2"
                     /gene_synonym="NID-2"
                     /coded_by="XM_005267406.5:66..4130"
                     /db_xref="GeneID:22795"
                     /db_xref="HGNC:HGNC:13389"
                     /db_xref="MIM:605399"
ORIGIN      
        1 megdrvagrp vlsslpvlll lpllmlraaa lhpdelfphg eswgdqllqe gddessavvk
       61 lanplhfyea rfsnlyvgtn giistqdfpr etqyvdydfp tdfpaiapfl adidtshgrg
      121 rvlyredtsp avlglaaryv ragfprsarf tpthaflatw eqvgayeevk rgalpsgeln
      181 tfqavlasdg sdsyalflyp anglqflgtr pkesynvqlq lparvgfcrg eaddlksegp
      241 yfsltsteqs vknlyqlsnl gipgvwafhi gstspldnvr paavgdlsaa hssvplgrsf
      301 shatalesdy nednldyydv neeeaeylpg epeealnghs sidvsfqskv dtkplegris
      361 ppdsdlsspl hptptywpfy petesstldp htkegtslge vggpdlkgqv epwderetrs
      421 pappevdrds lapswetppp ypengsiqpy pdggpvpsem dvppahpeee ivlrsypasg
      481 httplsrgty evglednigs ntevftynaa nketcehnhr qcsrhafctd yatgfcchcq
      541 skfygngkhc lpegaphrvn gkvsghlhvg htpvhftdvd lhayivgndg raytaiship
      601 qpaaqallpl tpigglfgwl falekpgsen gfslagaaft hdmevtfypg eetvritqta
      661 egldpenyls iktniqgqvp yvsanftahi spykelyhys dstvtstssr dysltfgain
      721 qtwsyrihqn ityqvcrhap rhpsfpttqq lnvdrvfaly ndeervlrfa vtnqigpvke
      781 dsdptpgnpc ydgshmcdtt archpgtgvd ytcecasgyq gdgrncvden ecatgfhrcg
      841 pnsvcinlpg syrcecrsgy efaddrhtci yvdecsenrc hpaatcyntp gsfscrcqpg
      901 yygdgfqcip dstssltpce qqqrhaqaqy aypgarfhip qcdeqgnflp lqchgstgfc
      961 wcvdpdghev pgtqtppgst pphcgpspep tqrppticer wrenllehyg gtprddqyvp
     1021 qcddlghfip lqchgksdfc wcvdkdgrev qgtrsqpgtt paciptvapp mvrptprpdv
     1081 tppsvgtfll ytqgqqigyl plngtrlqkd aaktllslhg siivgidydc rermvywtdv
     1141 agrtisragl elgaepetiv nsglispegl aidhirrtmy wtdsvldkie salldgserk
     1201 vlfytdlvnp raiavdpirg nlywtdwnre apkietssld genrrilint diglpngltf
     1261 dpfskllcwa dagtkklect lpdgtgrrvi qnnlkypfsi vsyadhfyht dwrrdgvvsv
     1321 nkhsgqftde ylpeqrshly gitavypycp tgrk
//
LOCUS       XP_005267464            1327 aa            linear   PRI 05-AUG-2025
DEFINITION  nidogen-2 isoform X3 [Homo sapiens].
ACCESSION   XP_005267464
VERSION     XP_005267464.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267407.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1327
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1327
                     /product="nidogen-2 isoform X3"
                     /calculated_mol_wt=146392
     Region          108..273
                     /region_name="NIDO"
                     /note="Extracellular domain of unknown function in nidogen
                     (entactin) and hypothetical proteins; smart00539"
                     /db_xref="CDD:214712"
     Region          488..523
                     /region_name="EGF_3"
                     /note="EGF domain; pfam12947"
                     /db_xref="CDD:463759"
     Region          525..757
                     /region_name="G2F"
                     /note="G2 nidogen domain and fibulin; smart00682"
                     /db_xref="CDD:214774"
     Site            order(531,555,557,564,566,568,732,737,741,743)
                     /site_type="other"
                     /note="collagen/perlecan interaction surface [polypeptide
                     binding]"
                     /db_xref="CDD:238158"
     Region          763..799
                     /region_name="EGF_3"
                     /note="EGF domain; pfam12947"
                     /db_xref="CDD:463759"
     Region          801..843
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain; smart00179"
                     /db_xref="CDD:214542"
     Site            order(801,804,820)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          848..881
                     /region_name="EGF_3"
                     /note="EGF domain; pfam12947"
                     /db_xref="CDD:463759"
     Region          891..957
                     /region_name="TY"
                     /note="Thyroglobulin type I repeats.; The N-terminal
                     region of human thyroglobulin contains 11 type-1 repeats
                     TY repeats are proposed to be inhibitors of cysteine
                     proteases; cd00191"
                     /db_xref="CDD:238114"
     Site            order(896,910,928,932)
                     /site_type="active"
                     /note="protease interaction site [active]"
                     /db_xref="CDD:238114"
     Region          971..1036
                     /region_name="TY"
                     /note="Thyroglobulin type I repeats.; The N-terminal
                     region of human thyroglobulin contains 11 type-1 repeats
                     TY repeats are proposed to be inhibitors of cysteine
                     proteases; cd00191"
                     /db_xref="CDD:238114"
     Site            order(975,990,1008,1012)
                     /site_type="active"
                     /note="protease interaction site [active]"
                     /db_xref="CDD:238114"
     Region          1086..1124
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          1130..1172
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          1173..1217
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          1218..1260
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     CDS             1..1327
                     /gene="NID2"
                     /gene_synonym="NID-2"
                     /coded_by="XM_005267407.5:66..4049"
                     /db_xref="GeneID:22795"
                     /db_xref="HGNC:HGNC:13389"
                     /db_xref="MIM:605399"
ORIGIN      
        1 megdrvagrp vlsslpvlll lpllmlraaa lhpdelfphg eswgdqllqe gddessavvk
       61 lanplhfyea rfsnlyvgtn giistqdfpr etqyvdydfp tdfpaiapfl adidtshgrg
      121 rvlyredtsp avlglaaryv ragfprsarf tpthaflatw eqvgayeevk rgalpsgeln
      181 tfqavlasdg sdsyalflyp anglqflgtr pkesynvqlq lparvgfcrg eaddlksegp
      241 yfsltsteqs vknlyqlsnl gipgvwafhi gstspldnvr paavgdlsaa hssvplgrsf
      301 shatalesdy nednldyydv neeeaeylpg epeealnghs sidvsfqskv dtkpleesst
      361 ldphtkegts lgevggpdlk gqvepwdere trspappevd rdslapswet pppypengsi
      421 qpypdggpvp semdvppahp eeeivlrsyp asghttplsr gtyevgledn igsntevfty
      481 naanketceh nhrqcsrhaf ctdyatgfcc hcqskfygng khclpegaph rvngkvsghl
      541 hvghtpvhft dvdlhayivg ndgraytais hipqpaaqal lpltpigglf gwlfalekpg
      601 sengfslaga afthdmevtf ypgeetvrit qtaegldpen ylsiktniqg qvpyvsanft
      661 ahispykely hysdstvtst ssrdysltfg ainqtwsyri hqnityqvcr haprhpsfpt
      721 tqqlnvdrvf alyndeervl rfavtnqigp vkedsdptpg npcydgshmc dttarchpgt
      781 gvdytcecas gyqgdgrncv denecatgfh rcgpnsvcin lpgsyrcecr sgyefaddrh
      841 tciyvdecse nrchpaatcy ntpgsfscrc qpgyygdgfq cipdstsslt pceqqqrhaq
      901 aqyaypgarf hipqcdeqgn flplqchgst gfcwcvdpdg hevpgtqtpp gstpphcgps
      961 peptqrppti cerwrenlle hyggtprddq yvpqcddlgh fiplqchgks dfcwcvdkdg
     1021 revqgtrsqp gttpaciptv appmvrptpr pdvtppsvgt fllytqgqqi gylplngtrl
     1081 qkdaaktlls lhgsiivgid ydcrermvyw tdvagrtisr aglelgaepe tivnsglisp
     1141 eglaidhirr tmywtdsvld kiesalldgs erkvlfytdl vnpraiavdp irgnlywtdw
     1201 nreapkiets sldgenrril intdiglpng ltfdpfskll cwadagtkkl ectlpdgtgr
     1261 rviqnnlkyp fsivsyadhf yhtdwrrdgv vsvnkhsgqf tdeylpeqrs hlygitavyp
     1321 ycptgrk
//
LOCUS       XP_047287037             212 aa            linear   PRI 05-AUG-2025
DEFINITION  tubulinyl-Tyr carboxypeptidase 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047287037
VERSION     XP_047287037.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431081.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..212
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..212
                     /product="tubulinyl-Tyr carboxypeptidase 1 isoform X1"
                     /calculated_mol_wt=24212
     Region          <1..149
                     /region_name="Vasohibin"
                     /note="pfam14822"
                     /db_xref="CDD:434242"
     CDS             1..212
                     /gene="VASH1"
                     /gene_synonym="KIAA1036; TTCP 1"
                     /coded_by="XM_047431081.1:944..1582"
                     /db_xref="GeneID:22846"
                     /db_xref="HGNC:HGNC:19964"
                     /db_xref="MIM:609011"
ORIGIN      
        1 mdlakemtke alpikcleav ilgiyltnsm ptlerfpisf ktyfsgnyfr hivlgvnfag
       61 rygalgmsrr edlmykppaf rtlselvldf eaaygrcwhv lkkvklgqsv shdphsveqi
      121 ewkhsvldve rlgrddfrke lerhardmrl kigkgtgpps ptkdrkkdvs spqraqssph
      181 rrnsrserrp sgdkktsepk ampdlngyqi rv
//
LOCUS       XP_047287038             212 aa            linear   PRI 05-AUG-2025
DEFINITION  tubulinyl-Tyr carboxypeptidase 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047287038
VERSION     XP_047287038.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431082.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..212
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..212
                     /product="tubulinyl-Tyr carboxypeptidase 1 isoform X1"
                     /calculated_mol_wt=24212
     Region          <1..149
                     /region_name="Vasohibin"
                     /note="pfam14822"
                     /db_xref="CDD:434242"
     CDS             1..212
                     /gene="VASH1"
                     /gene_synonym="KIAA1036; TTCP 1"
                     /coded_by="XM_047431082.1:2083..2721"
                     /db_xref="GeneID:22846"
                     /db_xref="HGNC:HGNC:19964"
                     /db_xref="MIM:609011"
ORIGIN      
        1 mdlakemtke alpikcleav ilgiyltnsm ptlerfpisf ktyfsgnyfr hivlgvnfag
       61 rygalgmsrr edlmykppaf rtlselvldf eaaygrcwhv lkkvklgqsv shdphsveqi
      121 ewkhsvldve rlgrddfrke lerhardmrl kigkgtgpps ptkdrkkdvs spqraqssph
      181 rrnsrserrp sgdkktsepk ampdlngyqi rv
//
LOCUS       XP_016876576             212 aa            linear   PRI 05-AUG-2025
DEFINITION  tubulinyl-Tyr carboxypeptidase 1 isoform X1 [Homo sapiens].
ACCESSION   XP_016876576
VERSION     XP_016876576.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021087.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..212
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..212
                     /product="tubulinyl-Tyr carboxypeptidase 1 isoform X1"
                     /calculated_mol_wt=24212
     Region          <1..149
                     /region_name="Vasohibin"
                     /note="pfam14822"
                     /db_xref="CDD:434242"
     CDS             1..212
                     /gene="VASH1"
                     /gene_synonym="KIAA1036; TTCP 1"
                     /coded_by="XM_017021087.2:2044..2682"
                     /db_xref="GeneID:22846"
                     /db_xref="HGNC:HGNC:19964"
                     /db_xref="MIM:609011"
ORIGIN      
        1 mdlakemtke alpikcleav ilgiyltnsm ptlerfpisf ktyfsgnyfr hivlgvnfag
       61 rygalgmsrr edlmykppaf rtlselvldf eaaygrcwhv lkkvklgqsv shdphsveqi
      121 ewkhsvldve rlgrddfrke lerhardmrl kigkgtgpps ptkdrkkdvs spqraqssph
      181 rrnsrserrp sgdkktsepk ampdlngyqi rv
//
LOCUS       XP_047287039             212 aa            linear   PRI 05-AUG-2025
DEFINITION  tubulinyl-Tyr carboxypeptidase 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047287039
VERSION     XP_047287039.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431083.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..212
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..212
                     /product="tubulinyl-Tyr carboxypeptidase 1 isoform X1"
                     /calculated_mol_wt=24212
     Region          <1..149
                     /region_name="Vasohibin"
                     /note="pfam14822"
                     /db_xref="CDD:434242"
     CDS             1..212
                     /gene="VASH1"
                     /gene_synonym="KIAA1036; TTCP 1"
                     /coded_by="XM_047431083.1:2064..2702"
                     /db_xref="GeneID:22846"
                     /db_xref="HGNC:HGNC:19964"
                     /db_xref="MIM:609011"
ORIGIN      
        1 mdlakemtke alpikcleav ilgiyltnsm ptlerfpisf ktyfsgnyfr hivlgvnfag
       61 rygalgmsrr edlmykppaf rtlselvldf eaaygrcwhv lkkvklgqsv shdphsveqi
      121 ewkhsvldve rlgrddfrke lerhardmrl kigkgtgpps ptkdrkkdvs spqraqssph
      181 rrnsrserrp sgdkktsepk ampdlngyqi rv
//
LOCUS       XP_047287040             212 aa            linear   PRI 05-AUG-2025
DEFINITION  tubulinyl-Tyr carboxypeptidase 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047287040
VERSION     XP_047287040.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431084.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..212
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..212
                     /product="tubulinyl-Tyr carboxypeptidase 1 isoform X1"
                     /calculated_mol_wt=24212
     Region          <1..149
                     /region_name="Vasohibin"
                     /note="pfam14822"
                     /db_xref="CDD:434242"
     CDS             1..212
                     /gene="VASH1"
                     /gene_synonym="KIAA1036; TTCP 1"
                     /coded_by="XM_047431084.1:1899..2537"
                     /db_xref="GeneID:22846"
                     /db_xref="HGNC:HGNC:19964"
                     /db_xref="MIM:609011"
ORIGIN      
        1 mdlakemtke alpikcleav ilgiyltnsm ptlerfpisf ktyfsgnyfr hivlgvnfag
       61 rygalgmsrr edlmykppaf rtlselvldf eaaygrcwhv lkkvklgqsv shdphsveqi
      121 ewkhsvldve rlgrddfrke lerhardmrl kigkgtgpps ptkdrkkdvs spqraqssph
      181 rrnsrserrp sgdkktsepk ampdlngyqi rv
//
LOCUS       XP_047287041             212 aa            linear   PRI 05-AUG-2025
DEFINITION  tubulinyl-Tyr carboxypeptidase 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047287041
VERSION     XP_047287041.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431085.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..212
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..212
                     /product="tubulinyl-Tyr carboxypeptidase 1 isoform X1"
                     /calculated_mol_wt=24212
     Region          <1..149
                     /region_name="Vasohibin"
                     /note="pfam14822"
                     /db_xref="CDD:434242"
     CDS             1..212
                     /gene="VASH1"
                     /gene_synonym="KIAA1036; TTCP 1"
                     /coded_by="XM_047431085.1:1880..2518"
                     /db_xref="GeneID:22846"
                     /db_xref="HGNC:HGNC:19964"
                     /db_xref="MIM:609011"
ORIGIN      
        1 mdlakemtke alpikcleav ilgiyltnsm ptlerfpisf ktyfsgnyfr hivlgvnfag
       61 rygalgmsrr edlmykppaf rtlselvldf eaaygrcwhv lkkvklgqsv shdphsveqi
      121 ewkhsvldve rlgrddfrke lerhardmrl kigkgtgpps ptkdrkkdvs spqraqssph
      181 rrnsrserrp sgdkktsepk ampdlngyqi rv
//
LOCUS       XP_016876580             183 aa            linear   PRI 05-AUG-2025
DEFINITION  tubulinyl-Tyr carboxypeptidase 1 isoform X2 [Homo sapiens].
ACCESSION   XP_016876580
VERSION     XP_016876580.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021091.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..183
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..183
                     /product="tubulinyl-Tyr carboxypeptidase 1 isoform X2"
                     /calculated_mol_wt=21021
     Region          <1..120
                     /region_name="Vasohibin"
                     /note="pfam14822"
                     /db_xref="CDD:434242"
     CDS             1..183
                     /gene="VASH1"
                     /gene_synonym="KIAA1036; TTCP 1"
                     /coded_by="XM_017021091.2:1403..1954"
                     /db_xref="GeneID:22846"
                     /db_xref="HGNC:HGNC:19964"
                     /db_xref="MIM:609011"
ORIGIN      
        1 mptlerfpis fktyfsgnyf rhivlgvnfa grygalgmsr redlmykppa frtlselvld
       61 feaaygrcwh vlkkvklgqs vshdphsveq iewkhsvldv erlgrddfrk elerhardmr
      121 lkigkgtgpp sptkdrkkdv sspqraqssp hrrnsrserr psgdkktsep kampdlngyq
      181 irv
//
LOCUS       XP_011534865             379 aa            linear   PRI 05-AUG-2025
DEFINITION  beclin 1-associated autophagy-related key regulator isoform X1
            [Homo sapiens].
ACCESSION   XP_011534865
VERSION     XP_011534865.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536563.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..379
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..379
                     /product="beclin 1-associated autophagy-related key
                     regulator isoform X1"
                     /calculated_mol_wt=42303
     Region          1..275
                     /region_name="ATG14"
                     /note="Vacuolar sorting 38 and autophagy-related subunit
                     14; pfam10186"
                     /db_xref="CDD:462986"
     CDS             1..379
                     /gene="ATG14"
                     /gene_synonym="ATG14L; BARKOR; KIAA0831"
                     /coded_by="XM_011536563.3:81..1220"
                     /db_xref="GeneID:22863"
                     /db_xref="HGNC:HGNC:19962"
                     /db_xref="MIM:613515"
ORIGIN      
        1 msckmrieql kqtickgnee meknsegllk tkeknqklys raqrhqekke kiqrhnrklg
       61 dlvekktidl rshyerlanl rrshilelts vifpieevkt gvrdpadvss esdsamtsst
      121 vsklaearrt tylsgrwvcd dhngdtsisi tgpwislpnn gdysayyswv eekkttqgpd
      181 meqsnpayti saalcyatql vnilshildv nlpkklcnse fcgenlskqk ftravkklna
      241 nilylcfsqh vnldqlqplh tlrnlmylvs pssehlgrsg pfevradlee smefvdpgva
      301 gesdesgder vsdeetdlgt dwenlpsprf cdipsqsvev sqsqstqasp piasssaggm
      361 issaaasvts wfkaytghr
//
LOCUS       XP_011534867             191 aa            linear   PRI 05-AUG-2025
DEFINITION  peptidyl-prolyl cis-trans isomerase FKBP3 isoform X1 [Homo
            sapiens].
ACCESSION   XP_011534867
VERSION     XP_011534867.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536565.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..191
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..191
                     /product="peptidyl-prolyl cis-trans isomerase FKBP3
                     isoform X1"
                     /calculated_mol_wt=21328
     Region          <3..40
                     /region_name="BTHB"
                     /note="basic tilted helix bundle (BTHB) domain; cl39748"
                     /db_xref="CDD:477119"
     Region          91..188
                     /region_name="FKBP_C"
                     /note="FKBP-type peptidyl-prolyl cis-trans isomerase;
                     pfam00254"
                     /db_xref="CDD:459735"
     CDS             1..191
                     /gene="FKBP3"
                     /gene_synonym="FKBP-25; FKBP-3; FKBP25; PPIase"
                     /coded_by="XM_011536565.4:1988..2563"
                     /db_xref="GeneID:2287"
                     /db_xref="HGNC:HGNC:3719"
                     /db_xref="MIM:186947"
ORIGIN      
        1 mlkflaehkl lgniknvakt ankdhlvtay nhlfetkrfk gtesiskvse qvknvklned
       61 kpketkseet ldegppkytk svlkkgdktn fpkkgdvvhc wytgtlqdgt vfdtniqtsa
      121 kkkknakpls fkvgvgkvir gwdealltms kgekarleie pewaygkkgq pdakippnak
      181 ltfevelvdi d
//
LOCUS       XP_047287042             713 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger and BTB domain-containing protein 1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_047287042
VERSION     XP_047287042.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431086.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..713
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..713
                     /product="zinc finger and BTB domain-containing protein 1
                     isoform X1"
                     /calculated_mol_wt=81885
     Region          3..116
                     /region_name="BTB_POZ_ZBTB1"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 1 (ZBTB1); cd18192"
                     /db_xref="CDD:349501"
     Region          536..574
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          580..600
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(585,587,589,591..592,595..596,599,613,615,619..620,
                     623..624,627,641,644,646,648..649,651..652,655)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          608..628
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          636..656
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          664..684
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          688..709
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275371"
     CDS             1..713
                     /gene="ZBTB1"
                     /gene_synonym="ZNF909"
                     /coded_by="XM_047431086.1:394..2535"
                     /db_xref="GeneID:22890"
                     /db_xref="HGNC:HGNC:20259"
                     /db_xref="MIM:616578"
ORIGIN      
        1 makpshssyv lqqlnnqrew gflcdcciai ddiyfqahka vlaacssyfr mffmnhqhst
       61 aqlnlsnmki saecfdlilq fmylgkimta pssfeqfkva mnylqlynvp dclediqdad
      121 cssskcsssa sskqnskmif gvrmyedtva rngneanrwc aepsstvntp hnreadeesl
      181 qlgnfpeplf dvckkssvsk lstpkervsr rfgrsftcds cgfgfscekl ldehvltctn
      241 rhlyqntrsy hrivdirdgk dsnikaefge kdssktfsaq tdkyrgdtsq aaddsasttg
      301 srksstvese iaseeksraa erkriiikme pediptdelk dfniikvtdk dcnestdnde
      361 ledepeepfy ryyveedvsi kksgrktlkp rmsvsaderg glenmrppnn sspvqedaen
      421 ascelcglti teedlsshyl akhienicac gkcgqilvkg rqlqehaqrc gepqdltmng
      481 lgnteekmdl eenpdeqsei rdmfvemldd frdnhyqins iqkkqlfkhs acpfrcpncg
      541 qrfetenlvv ehmsscldqd mfksaimeen erdhrrkhfc nlcgkgfyqr chlrehytvh
      601 tkekqfvcqt cgkqflrerq lrlhndmhkg maryvcsicd qgnfrkhdhv rhmishlsag
      661 eticqvcfqi fpnneqleqh mdvhlytcgi cgakfnlrkd mrshynakhl krt
//
LOCUS       XP_047287043             713 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger and BTB domain-containing protein 1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_047287043
VERSION     XP_047287043.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431087.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..713
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..713
                     /product="zinc finger and BTB domain-containing protein 1
                     isoform X1"
                     /calculated_mol_wt=81885
     Region          3..116
                     /region_name="BTB_POZ_ZBTB1"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 1 (ZBTB1); cd18192"
                     /db_xref="CDD:349501"
     Region          536..574
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          580..600
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(585,587,589,591..592,595..596,599,613,615,619..620,
                     623..624,627,641,644,646,648..649,651..652,655)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          608..628
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          636..656
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          664..684
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          688..709
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275371"
     CDS             1..713
                     /gene="ZBTB1"
                     /gene_synonym="ZNF909"
                     /coded_by="XM_047431087.1:353..2494"
                     /db_xref="GeneID:22890"
                     /db_xref="HGNC:HGNC:20259"
                     /db_xref="MIM:616578"
ORIGIN      
        1 makpshssyv lqqlnnqrew gflcdcciai ddiyfqahka vlaacssyfr mffmnhqhst
       61 aqlnlsnmki saecfdlilq fmylgkimta pssfeqfkva mnylqlynvp dclediqdad
      121 cssskcsssa sskqnskmif gvrmyedtva rngneanrwc aepsstvntp hnreadeesl
      181 qlgnfpeplf dvckkssvsk lstpkervsr rfgrsftcds cgfgfscekl ldehvltctn
      241 rhlyqntrsy hrivdirdgk dsnikaefge kdssktfsaq tdkyrgdtsq aaddsasttg
      301 srksstvese iaseeksraa erkriiikme pediptdelk dfniikvtdk dcnestdnde
      361 ledepeepfy ryyveedvsi kksgrktlkp rmsvsaderg glenmrppnn sspvqedaen
      421 ascelcglti teedlsshyl akhienicac gkcgqilvkg rqlqehaqrc gepqdltmng
      481 lgnteekmdl eenpdeqsei rdmfvemldd frdnhyqins iqkkqlfkhs acpfrcpncg
      541 qrfetenlvv ehmsscldqd mfksaimeen erdhrrkhfc nlcgkgfyqr chlrehytvh
      601 tkekqfvcqt cgkqflrerq lrlhndmhkg maryvcsicd qgnfrkhdhv rhmishlsag
      661 eticqvcfqi fpnneqleqh mdvhlytcgi cgakfnlrkd mrshynakhl krt
//
LOCUS       XP_005267467             713 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger and BTB domain-containing protein 1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_005267467
VERSION     XP_005267467.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267410.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..713
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..713
                     /product="zinc finger and BTB domain-containing protein 1
                     isoform X1"
                     /calculated_mol_wt=81885
     Region          3..116
                     /region_name="BTB_POZ_ZBTB1"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 1 (ZBTB1); cd18192"
                     /db_xref="CDD:349501"
     Region          536..574
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          580..600
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(585,587,589,591..592,595..596,599,613,615,619..620,
                     623..624,627,641,644,646,648..649,651..652,655)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          608..628
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          636..656
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          664..684
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          688..709
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275371"
     CDS             1..713
                     /gene="ZBTB1"
                     /gene_synonym="ZNF909"
                     /coded_by="XM_005267410.2:484..2625"
                     /db_xref="GeneID:22890"
                     /db_xref="HGNC:HGNC:20259"
                     /db_xref="MIM:616578"
ORIGIN      
        1 makpshssyv lqqlnnqrew gflcdcciai ddiyfqahka vlaacssyfr mffmnhqhst
       61 aqlnlsnmki saecfdlilq fmylgkimta pssfeqfkva mnylqlynvp dclediqdad
      121 cssskcsssa sskqnskmif gvrmyedtva rngneanrwc aepsstvntp hnreadeesl
      181 qlgnfpeplf dvckkssvsk lstpkervsr rfgrsftcds cgfgfscekl ldehvltctn
      241 rhlyqntrsy hrivdirdgk dsnikaefge kdssktfsaq tdkyrgdtsq aaddsasttg
      301 srksstvese iaseeksraa erkriiikme pediptdelk dfniikvtdk dcnestdnde
      361 ledepeepfy ryyveedvsi kksgrktlkp rmsvsaderg glenmrppnn sspvqedaen
      421 ascelcglti teedlsshyl akhienicac gkcgqilvkg rqlqehaqrc gepqdltmng
      481 lgnteekmdl eenpdeqsei rdmfvemldd frdnhyqins iqkkqlfkhs acpfrcpncg
      541 qrfetenlvv ehmsscldqd mfksaimeen erdhrrkhfc nlcgkgfyqr chlrehytvh
      601 tkekqfvcqt cgkqflrerq lrlhndmhkg maryvcsicd qgnfrkhdhv rhmishlsag
      661 eticqvcfqi fpnneqleqh mdvhlytcgi cgakfnlrkd mrshynakhl krt
//
LOCUS       XP_011534868             713 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger and BTB domain-containing protein 1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_011534868
VERSION     XP_011534868.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536566.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..713
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..713
                     /product="zinc finger and BTB domain-containing protein 1
                     isoform X1"
                     /calculated_mol_wt=81885
     Region          3..116
                     /region_name="BTB_POZ_ZBTB1"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 1 (ZBTB1); cd18192"
                     /db_xref="CDD:349501"
     Region          536..574
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          580..600
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(585,587,589,591..592,595..596,599,613,615,619..620,
                     623..624,627,641,644,646,648..649,651..652,655)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          608..628
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          636..656
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          664..684
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          688..709
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275371"
     CDS             1..713
                     /gene="ZBTB1"
                     /gene_synonym="ZNF909"
                     /coded_by="XM_011536566.3:348..2489"
                     /db_xref="GeneID:22890"
                     /db_xref="HGNC:HGNC:20259"
                     /db_xref="MIM:616578"
ORIGIN      
        1 makpshssyv lqqlnnqrew gflcdcciai ddiyfqahka vlaacssyfr mffmnhqhst
       61 aqlnlsnmki saecfdlilq fmylgkimta pssfeqfkva mnylqlynvp dclediqdad
      121 cssskcsssa sskqnskmif gvrmyedtva rngneanrwc aepsstvntp hnreadeesl
      181 qlgnfpeplf dvckkssvsk lstpkervsr rfgrsftcds cgfgfscekl ldehvltctn
      241 rhlyqntrsy hrivdirdgk dsnikaefge kdssktfsaq tdkyrgdtsq aaddsasttg
      301 srksstvese iaseeksraa erkriiikme pediptdelk dfniikvtdk dcnestdnde
      361 ledepeepfy ryyveedvsi kksgrktlkp rmsvsaderg glenmrppnn sspvqedaen
      421 ascelcglti teedlsshyl akhienicac gkcgqilvkg rqlqehaqrc gepqdltmng
      481 lgnteekmdl eenpdeqsei rdmfvemldd frdnhyqins iqkkqlfkhs acpfrcpncg
      541 qrfetenlvv ehmsscldqd mfksaimeen erdhrrkhfc nlcgkgfyqr chlrehytvh
      601 tkekqfvcqt cgkqflrerq lrlhndmhkg maryvcsicd qgnfrkhdhv rhmishlsag
      661 eticqvcfqi fpnneqleqh mdvhlytcgi cgakfnlrkd mrshynakhl krt
//
LOCUS       XP_047287046             713 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger and BTB domain-containing protein 1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_047287046
VERSION     XP_047287046.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431090.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..713
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..713
                     /product="zinc finger and BTB domain-containing protein 1
                     isoform X1"
                     /calculated_mol_wt=81885
     Region          3..116
                     /region_name="BTB_POZ_ZBTB1"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 1 (ZBTB1); cd18192"
                     /db_xref="CDD:349501"
     Region          536..574
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          580..600
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(585,587,589,591..592,595..596,599,613,615,619..620,
                     623..624,627,641,644,646,648..649,651..652,655)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          608..628
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          636..656
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          664..684
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          688..709
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275371"
     CDS             1..713
                     /gene="ZBTB1"
                     /gene_synonym="ZNF909"
                     /coded_by="XM_047431090.1:641..2782"
                     /db_xref="GeneID:22890"
                     /db_xref="HGNC:HGNC:20259"
                     /db_xref="MIM:616578"
ORIGIN      
        1 makpshssyv lqqlnnqrew gflcdcciai ddiyfqahka vlaacssyfr mffmnhqhst
       61 aqlnlsnmki saecfdlilq fmylgkimta pssfeqfkva mnylqlynvp dclediqdad
      121 cssskcsssa sskqnskmif gvrmyedtva rngneanrwc aepsstvntp hnreadeesl
      181 qlgnfpeplf dvckkssvsk lstpkervsr rfgrsftcds cgfgfscekl ldehvltctn
      241 rhlyqntrsy hrivdirdgk dsnikaefge kdssktfsaq tdkyrgdtsq aaddsasttg
      301 srksstvese iaseeksraa erkriiikme pediptdelk dfniikvtdk dcnestdnde
      361 ledepeepfy ryyveedvsi kksgrktlkp rmsvsaderg glenmrppnn sspvqedaen
      421 ascelcglti teedlsshyl akhienicac gkcgqilvkg rqlqehaqrc gepqdltmng
      481 lgnteekmdl eenpdeqsei rdmfvemldd frdnhyqins iqkkqlfkhs acpfrcpncg
      541 qrfetenlvv ehmsscldqd mfksaimeen erdhrrkhfc nlcgkgfyqr chlrehytvh
      601 tkekqfvcqt cgkqflrerq lrlhndmhkg maryvcsicd qgnfrkhdhv rhmishlsag
      661 eticqvcfqi fpnneqleqh mdvhlytcgi cgakfnlrkd mrshynakhl krt
//
LOCUS       XP_047287047             713 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger and BTB domain-containing protein 1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_047287047
VERSION     XP_047287047.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431091.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..713
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..713
                     /product="zinc finger and BTB domain-containing protein 1
                     isoform X1"
                     /calculated_mol_wt=81885
     Region          3..116
                     /region_name="BTB_POZ_ZBTB1"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 1 (ZBTB1); cd18192"
                     /db_xref="CDD:349501"
     Region          536..574
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          580..600
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(585,587,589,591..592,595..596,599,613,615,619..620,
                     623..624,627,641,644,646,648..649,651..652,655)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          608..628
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          636..656
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          664..684
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          688..709
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275371"
     CDS             1..713
                     /gene="ZBTB1"
                     /gene_synonym="ZNF909"
                     /coded_by="XM_047431091.1:414..2555"
                     /db_xref="GeneID:22890"
                     /db_xref="HGNC:HGNC:20259"
                     /db_xref="MIM:616578"
ORIGIN      
        1 makpshssyv lqqlnnqrew gflcdcciai ddiyfqahka vlaacssyfr mffmnhqhst
       61 aqlnlsnmki saecfdlilq fmylgkimta pssfeqfkva mnylqlynvp dclediqdad
      121 cssskcsssa sskqnskmif gvrmyedtva rngneanrwc aepsstvntp hnreadeesl
      181 qlgnfpeplf dvckkssvsk lstpkervsr rfgrsftcds cgfgfscekl ldehvltctn
      241 rhlyqntrsy hrivdirdgk dsnikaefge kdssktfsaq tdkyrgdtsq aaddsasttg
      301 srksstvese iaseeksraa erkriiikme pediptdelk dfniikvtdk dcnestdnde
      361 ledepeepfy ryyveedvsi kksgrktlkp rmsvsaderg glenmrppnn sspvqedaen
      421 ascelcglti teedlsshyl akhienicac gkcgqilvkg rqlqehaqrc gepqdltmng
      481 lgnteekmdl eenpdeqsei rdmfvemldd frdnhyqins iqkkqlfkhs acpfrcpncg
      541 qrfetenlvv ehmsscldqd mfksaimeen erdhrrkhfc nlcgkgfyqr chlrehytvh
      601 tkekqfvcqt cgkqflrerq lrlhndmhkg maryvcsicd qgnfrkhdhv rhmishlsag
      661 eticqvcfqi fpnneqleqh mdvhlytcgi cgakfnlrkd mrshynakhl krt
//
LOCUS       XP_047287048             713 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger and BTB domain-containing protein 1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_047287048
VERSION     XP_047287048.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431092.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..713
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..713
                     /product="zinc finger and BTB domain-containing protein 1
                     isoform X1"
                     /calculated_mol_wt=81885
     Region          3..116
                     /region_name="BTB_POZ_ZBTB1"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 1 (ZBTB1); cd18192"
                     /db_xref="CDD:349501"
     Region          536..574
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          580..600
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(585,587,589,591..592,595..596,599,613,615,619..620,
                     623..624,627,641,644,646,648..649,651..652,655)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          608..628
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          636..656
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          664..684
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          688..709
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275371"
     CDS             1..713
                     /gene="ZBTB1"
                     /gene_synonym="ZNF909"
                     /coded_by="XM_047431092.1:830..2971"
                     /db_xref="GeneID:22890"
                     /db_xref="HGNC:HGNC:20259"
                     /db_xref="MIM:616578"
ORIGIN      
        1 makpshssyv lqqlnnqrew gflcdcciai ddiyfqahka vlaacssyfr mffmnhqhst
       61 aqlnlsnmki saecfdlilq fmylgkimta pssfeqfkva mnylqlynvp dclediqdad
      121 cssskcsssa sskqnskmif gvrmyedtva rngneanrwc aepsstvntp hnreadeesl
      181 qlgnfpeplf dvckkssvsk lstpkervsr rfgrsftcds cgfgfscekl ldehvltctn
      241 rhlyqntrsy hrivdirdgk dsnikaefge kdssktfsaq tdkyrgdtsq aaddsasttg
      301 srksstvese iaseeksraa erkriiikme pediptdelk dfniikvtdk dcnestdnde
      361 ledepeepfy ryyveedvsi kksgrktlkp rmsvsaderg glenmrppnn sspvqedaen
      421 ascelcglti teedlsshyl akhienicac gkcgqilvkg rqlqehaqrc gepqdltmng
      481 lgnteekmdl eenpdeqsei rdmfvemldd frdnhyqins iqkkqlfkhs acpfrcpncg
      541 qrfetenlvv ehmsscldqd mfksaimeen erdhrrkhfc nlcgkgfyqr chlrehytvh
      601 tkekqfvcqt cgkqflrerq lrlhndmhkg maryvcsicd qgnfrkhdhv rhmishlsag
      661 eticqvcfqi fpnneqleqh mdvhlytcgi cgakfnlrkd mrshynakhl krt
//
LOCUS       XP_047287049             713 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger and BTB domain-containing protein 1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_047287049
VERSION     XP_047287049.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431093.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..713
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..713
                     /product="zinc finger and BTB domain-containing protein 1
                     isoform X1"
                     /calculated_mol_wt=81885
     Region          3..116
                     /region_name="BTB_POZ_ZBTB1"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 1 (ZBTB1); cd18192"
                     /db_xref="CDD:349501"
     Region          536..574
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          580..600
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(585,587,589,591..592,595..596,599,613,615,619..620,
                     623..624,627,641,644,646,648..649,651..652,655)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          608..628
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          636..656
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          664..684
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          688..709
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275371"
     CDS             1..713
                     /gene="ZBTB1"
                     /gene_synonym="ZNF909"
                     /coded_by="XM_047431093.1:717..2858"
                     /db_xref="GeneID:22890"
                     /db_xref="HGNC:HGNC:20259"
                     /db_xref="MIM:616578"
ORIGIN      
        1 makpshssyv lqqlnnqrew gflcdcciai ddiyfqahka vlaacssyfr mffmnhqhst
       61 aqlnlsnmki saecfdlilq fmylgkimta pssfeqfkva mnylqlynvp dclediqdad
      121 cssskcsssa sskqnskmif gvrmyedtva rngneanrwc aepsstvntp hnreadeesl
      181 qlgnfpeplf dvckkssvsk lstpkervsr rfgrsftcds cgfgfscekl ldehvltctn
      241 rhlyqntrsy hrivdirdgk dsnikaefge kdssktfsaq tdkyrgdtsq aaddsasttg
      301 srksstvese iaseeksraa erkriiikme pediptdelk dfniikvtdk dcnestdnde
      361 ledepeepfy ryyveedvsi kksgrktlkp rmsvsaderg glenmrppnn sspvqedaen
      421 ascelcglti teedlsshyl akhienicac gkcgqilvkg rqlqehaqrc gepqdltmng
      481 lgnteekmdl eenpdeqsei rdmfvemldd frdnhyqins iqkkqlfkhs acpfrcpncg
      541 qrfetenlvv ehmsscldqd mfksaimeen erdhrrkhfc nlcgkgfyqr chlrehytvh
      601 tkekqfvcqt cgkqflrerq lrlhndmhkg maryvcsicd qgnfrkhdhv rhmishlsag
      661 eticqvcfqi fpnneqleqh mdvhlytcgi cgakfnlrkd mrshynakhl krt
//
LOCUS       XP_047287050             713 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger and BTB domain-containing protein 1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_047287050
VERSION     XP_047287050.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431094.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..713
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..713
                     /product="zinc finger and BTB domain-containing protein 1
                     isoform X1"
                     /calculated_mol_wt=81885
     Region          3..116
                     /region_name="BTB_POZ_ZBTB1"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 1 (ZBTB1); cd18192"
                     /db_xref="CDD:349501"
     Region          536..574
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          580..600
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(585,587,589,591..592,595..596,599,613,615,619..620,
                     623..624,627,641,644,646,648..649,651..652,655)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          608..628
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          636..656
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          664..684
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          688..709
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275371"
     CDS             1..713
                     /gene="ZBTB1"
                     /gene_synonym="ZNF909"
                     /coded_by="XM_047431094.1:840..2981"
                     /db_xref="GeneID:22890"
                     /db_xref="HGNC:HGNC:20259"
                     /db_xref="MIM:616578"
ORIGIN      
        1 makpshssyv lqqlnnqrew gflcdcciai ddiyfqahka vlaacssyfr mffmnhqhst
       61 aqlnlsnmki saecfdlilq fmylgkimta pssfeqfkva mnylqlynvp dclediqdad
      121 cssskcsssa sskqnskmif gvrmyedtva rngneanrwc aepsstvntp hnreadeesl
      181 qlgnfpeplf dvckkssvsk lstpkervsr rfgrsftcds cgfgfscekl ldehvltctn
      241 rhlyqntrsy hrivdirdgk dsnikaefge kdssktfsaq tdkyrgdtsq aaddsasttg
      301 srksstvese iaseeksraa erkriiikme pediptdelk dfniikvtdk dcnestdnde
      361 ledepeepfy ryyveedvsi kksgrktlkp rmsvsaderg glenmrppnn sspvqedaen
      421 ascelcglti teedlsshyl akhienicac gkcgqilvkg rqlqehaqrc gepqdltmng
      481 lgnteekmdl eenpdeqsei rdmfvemldd frdnhyqins iqkkqlfkhs acpfrcpncg
      541 qrfetenlvv ehmsscldqd mfksaimeen erdhrrkhfc nlcgkgfyqr chlrehytvh
      601 tkekqfvcqt cgkqflrerq lrlhndmhkg maryvcsicd qgnfrkhdhv rhmishlsag
      661 eticqvcfqi fpnneqleqh mdvhlytcgi cgakfnlrkd mrshynakhl krt
//
LOCUS       XP_047287051             713 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger and BTB domain-containing protein 1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_047287051
VERSION     XP_047287051.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431095.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..713
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..713
                     /product="zinc finger and BTB domain-containing protein 1
                     isoform X1"
                     /calculated_mol_wt=81885
     Region          3..116
                     /region_name="BTB_POZ_ZBTB1"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 1 (ZBTB1); cd18192"
                     /db_xref="CDD:349501"
     Region          536..574
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          580..600
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(585,587,589,591..592,595..596,599,613,615,619..620,
                     623..624,627,641,644,646,648..649,651..652,655)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          608..628
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          636..656
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          664..684
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          688..709
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275371"
     CDS             1..713
                     /gene="ZBTB1"
                     /gene_synonym="ZNF909"
                     /coded_by="XM_047431095.1:642..2783"
                     /db_xref="GeneID:22890"
                     /db_xref="HGNC:HGNC:20259"
                     /db_xref="MIM:616578"
ORIGIN      
        1 makpshssyv lqqlnnqrew gflcdcciai ddiyfqahka vlaacssyfr mffmnhqhst
       61 aqlnlsnmki saecfdlilq fmylgkimta pssfeqfkva mnylqlynvp dclediqdad
      121 cssskcsssa sskqnskmif gvrmyedtva rngneanrwc aepsstvntp hnreadeesl
      181 qlgnfpeplf dvckkssvsk lstpkervsr rfgrsftcds cgfgfscekl ldehvltctn
      241 rhlyqntrsy hrivdirdgk dsnikaefge kdssktfsaq tdkyrgdtsq aaddsasttg
      301 srksstvese iaseeksraa erkriiikme pediptdelk dfniikvtdk dcnestdnde
      361 ledepeepfy ryyveedvsi kksgrktlkp rmsvsaderg glenmrppnn sspvqedaen
      421 ascelcglti teedlsshyl akhienicac gkcgqilvkg rqlqehaqrc gepqdltmng
      481 lgnteekmdl eenpdeqsei rdmfvemldd frdnhyqins iqkkqlfkhs acpfrcpncg
      541 qrfetenlvv ehmsscldqd mfksaimeen erdhrrkhfc nlcgkgfyqr chlrehytvh
      601 tkekqfvcqt cgkqflrerq lrlhndmhkg maryvcsicd qgnfrkhdhv rhmishlsag
      661 eticqvcfqi fpnneqleqh mdvhlytcgi cgakfnlrkd mrshynakhl krt
//
LOCUS       XP_047287052             713 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger and BTB domain-containing protein 1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_047287052
VERSION     XP_047287052.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431096.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..713
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..713
                     /product="zinc finger and BTB domain-containing protein 1
                     isoform X1"
                     /calculated_mol_wt=81885
     Region          3..116
                     /region_name="BTB_POZ_ZBTB1"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 1 (ZBTB1); cd18192"
                     /db_xref="CDD:349501"
     Region          536..574
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          580..600
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(585,587,589,591..592,595..596,599,613,615,619..620,
                     623..624,627,641,644,646,648..649,651..652,655)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          608..628
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          636..656
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          664..684
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          688..709
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275371"
     CDS             1..713
                     /gene="ZBTB1"
                     /gene_synonym="ZNF909"
                     /coded_by="XM_047431096.1:789..2930"
                     /db_xref="GeneID:22890"
                     /db_xref="HGNC:HGNC:20259"
                     /db_xref="MIM:616578"
ORIGIN      
        1 makpshssyv lqqlnnqrew gflcdcciai ddiyfqahka vlaacssyfr mffmnhqhst
       61 aqlnlsnmki saecfdlilq fmylgkimta pssfeqfkva mnylqlynvp dclediqdad
      121 cssskcsssa sskqnskmif gvrmyedtva rngneanrwc aepsstvntp hnreadeesl
      181 qlgnfpeplf dvckkssvsk lstpkervsr rfgrsftcds cgfgfscekl ldehvltctn
      241 rhlyqntrsy hrivdirdgk dsnikaefge kdssktfsaq tdkyrgdtsq aaddsasttg
      301 srksstvese iaseeksraa erkriiikme pediptdelk dfniikvtdk dcnestdnde
      361 ledepeepfy ryyveedvsi kksgrktlkp rmsvsaderg glenmrppnn sspvqedaen
      421 ascelcglti teedlsshyl akhienicac gkcgqilvkg rqlqehaqrc gepqdltmng
      481 lgnteekmdl eenpdeqsei rdmfvemldd frdnhyqins iqkkqlfkhs acpfrcpncg
      541 qrfetenlvv ehmsscldqd mfksaimeen erdhrrkhfc nlcgkgfyqr chlrehytvh
      601 tkekqfvcqt cgkqflrerq lrlhndmhkg maryvcsicd qgnfrkhdhv rhmishlsag
      661 eticqvcfqi fpnneqleqh mdvhlytcgi cgakfnlrkd mrshynakhl krt
//
LOCUS       XP_047287053             713 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger and BTB domain-containing protein 1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_047287053
VERSION     XP_047287053.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431097.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..713
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..713
                     /product="zinc finger and BTB domain-containing protein 1
                     isoform X1"
                     /calculated_mol_wt=81885
     Region          3..116
                     /region_name="BTB_POZ_ZBTB1"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 1 (ZBTB1); cd18192"
                     /db_xref="CDD:349501"
     Region          536..574
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          580..600
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(585,587,589,591..592,595..596,599,613,615,619..620,
                     623..624,627,641,644,646,648..649,651..652,655)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          608..628
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          636..656
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          664..684
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          688..709
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275371"
     CDS             1..713
                     /gene="ZBTB1"
                     /gene_synonym="ZNF909"
                     /coded_by="XM_047431097.1:505..2646"
                     /db_xref="GeneID:22890"
                     /db_xref="HGNC:HGNC:20259"
                     /db_xref="MIM:616578"
ORIGIN      
        1 makpshssyv lqqlnnqrew gflcdcciai ddiyfqahka vlaacssyfr mffmnhqhst
       61 aqlnlsnmki saecfdlilq fmylgkimta pssfeqfkva mnylqlynvp dclediqdad
      121 cssskcsssa sskqnskmif gvrmyedtva rngneanrwc aepsstvntp hnreadeesl
      181 qlgnfpeplf dvckkssvsk lstpkervsr rfgrsftcds cgfgfscekl ldehvltctn
      241 rhlyqntrsy hrivdirdgk dsnikaefge kdssktfsaq tdkyrgdtsq aaddsasttg
      301 srksstvese iaseeksraa erkriiikme pediptdelk dfniikvtdk dcnestdnde
      361 ledepeepfy ryyveedvsi kksgrktlkp rmsvsaderg glenmrppnn sspvqedaen
      421 ascelcglti teedlsshyl akhienicac gkcgqilvkg rqlqehaqrc gepqdltmng
      481 lgnteekmdl eenpdeqsei rdmfvemldd frdnhyqins iqkkqlfkhs acpfrcpncg
      541 qrfetenlvv ehmsscldqd mfksaimeen erdhrrkhfc nlcgkgfyqr chlrehytvh
      601 tkekqfvcqt cgkqflrerq lrlhndmhkg maryvcsicd qgnfrkhdhv rhmishlsag
      661 eticqvcfqi fpnneqleqh mdvhlytcgi cgakfnlrkd mrshynakhl krt
//
LOCUS       XP_047287054             713 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger and BTB domain-containing protein 1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_047287054
VERSION     XP_047287054.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431098.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..713
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..713
                     /product="zinc finger and BTB domain-containing protein 1
                     isoform X1"
                     /calculated_mol_wt=81885
     Region          3..116
                     /region_name="BTB_POZ_ZBTB1"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 1 (ZBTB1); cd18192"
                     /db_xref="CDD:349501"
     Region          536..574
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          580..600
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(585,587,589,591..592,595..596,599,613,615,619..620,
                     623..624,627,641,644,646,648..649,651..652,655)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          608..628
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          636..656
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          664..684
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          688..709
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275371"
     CDS             1..713
                     /gene="ZBTB1"
                     /gene_synonym="ZNF909"
                     /coded_by="XM_047431098.1:562..2703"
                     /db_xref="GeneID:22890"
                     /db_xref="HGNC:HGNC:20259"
                     /db_xref="MIM:616578"
ORIGIN      
        1 makpshssyv lqqlnnqrew gflcdcciai ddiyfqahka vlaacssyfr mffmnhqhst
       61 aqlnlsnmki saecfdlilq fmylgkimta pssfeqfkva mnylqlynvp dclediqdad
      121 cssskcsssa sskqnskmif gvrmyedtva rngneanrwc aepsstvntp hnreadeesl
      181 qlgnfpeplf dvckkssvsk lstpkervsr rfgrsftcds cgfgfscekl ldehvltctn
      241 rhlyqntrsy hrivdirdgk dsnikaefge kdssktfsaq tdkyrgdtsq aaddsasttg
      301 srksstvese iaseeksraa erkriiikme pediptdelk dfniikvtdk dcnestdnde
      361 ledepeepfy ryyveedvsi kksgrktlkp rmsvsaderg glenmrppnn sspvqedaen
      421 ascelcglti teedlsshyl akhienicac gkcgqilvkg rqlqehaqrc gepqdltmng
      481 lgnteekmdl eenpdeqsei rdmfvemldd frdnhyqins iqkkqlfkhs acpfrcpncg
      541 qrfetenlvv ehmsscldqd mfksaimeen erdhrrkhfc nlcgkgfyqr chlrehytvh
      601 tkekqfvcqt cgkqflrerq lrlhndmhkg maryvcsicd qgnfrkhdhv rhmishlsag
      661 eticqvcfqi fpnneqleqh mdvhlytcgi cgakfnlrkd mrshynakhl krt
//
LOCUS       XP_047287056             713 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger and BTB domain-containing protein 1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_047287056
VERSION     XP_047287056.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431100.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..713
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..713
                     /product="zinc finger and BTB domain-containing protein 1
                     isoform X1"
                     /calculated_mol_wt=81885
     Region          3..116
                     /region_name="BTB_POZ_ZBTB1"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 1 (ZBTB1); cd18192"
                     /db_xref="CDD:349501"
     Region          536..574
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          580..600
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(585,587,589,591..592,595..596,599,613,615,619..620,
                     623..624,627,641,644,646,648..649,651..652,655)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          608..628
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          636..656
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          664..684
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          688..709
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275371"
     CDS             1..713
                     /gene="ZBTB1"
                     /gene_synonym="ZNF909"
                     /coded_by="XM_047431100.1:278..2419"
                     /db_xref="GeneID:22890"
                     /db_xref="HGNC:HGNC:20259"
                     /db_xref="MIM:616578"
ORIGIN      
        1 makpshssyv lqqlnnqrew gflcdcciai ddiyfqahka vlaacssyfr mffmnhqhst
       61 aqlnlsnmki saecfdlilq fmylgkimta pssfeqfkva mnylqlynvp dclediqdad
      121 cssskcsssa sskqnskmif gvrmyedtva rngneanrwc aepsstvntp hnreadeesl
      181 qlgnfpeplf dvckkssvsk lstpkervsr rfgrsftcds cgfgfscekl ldehvltctn
      241 rhlyqntrsy hrivdirdgk dsnikaefge kdssktfsaq tdkyrgdtsq aaddsasttg
      301 srksstvese iaseeksraa erkriiikme pediptdelk dfniikvtdk dcnestdnde
      361 ledepeepfy ryyveedvsi kksgrktlkp rmsvsaderg glenmrppnn sspvqedaen
      421 ascelcglti teedlsshyl akhienicac gkcgqilvkg rqlqehaqrc gepqdltmng
      481 lgnteekmdl eenpdeqsei rdmfvemldd frdnhyqins iqkkqlfkhs acpfrcpncg
      541 qrfetenlvv ehmsscldqd mfksaimeen erdhrrkhfc nlcgkgfyqr chlrehytvh
      601 tkekqfvcqt cgkqflrerq lrlhndmhkg maryvcsicd qgnfrkhdhv rhmishlsag
      661 eticqvcfqi fpnneqleqh mdvhlytcgi cgakfnlrkd mrshynakhl krt
//
LOCUS       XP_047287057             713 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger and BTB domain-containing protein 1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_047287057
VERSION     XP_047287057.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431101.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..713
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..713
                     /product="zinc finger and BTB domain-containing protein 1
                     isoform X1"
                     /calculated_mol_wt=81885
     Region          3..116
                     /region_name="BTB_POZ_ZBTB1"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 1 (ZBTB1); cd18192"
                     /db_xref="CDD:349501"
     Region          536..574
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          580..600
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(585,587,589,591..592,595..596,599,613,615,619..620,
                     623..624,627,641,644,646,648..649,651..652,655)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          608..628
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          636..656
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          664..684
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          688..709
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275371"
     CDS             1..713
                     /gene="ZBTB1"
                     /gene_synonym="ZNF909"
                     /coded_by="XM_047431101.1:704..2845"
                     /db_xref="GeneID:22890"
                     /db_xref="HGNC:HGNC:20259"
                     /db_xref="MIM:616578"
ORIGIN      
        1 makpshssyv lqqlnnqrew gflcdcciai ddiyfqahka vlaacssyfr mffmnhqhst
       61 aqlnlsnmki saecfdlilq fmylgkimta pssfeqfkva mnylqlynvp dclediqdad
      121 cssskcsssa sskqnskmif gvrmyedtva rngneanrwc aepsstvntp hnreadeesl
      181 qlgnfpeplf dvckkssvsk lstpkervsr rfgrsftcds cgfgfscekl ldehvltctn
      241 rhlyqntrsy hrivdirdgk dsnikaefge kdssktfsaq tdkyrgdtsq aaddsasttg
      301 srksstvese iaseeksraa erkriiikme pediptdelk dfniikvtdk dcnestdnde
      361 ledepeepfy ryyveedvsi kksgrktlkp rmsvsaderg glenmrppnn sspvqedaen
      421 ascelcglti teedlsshyl akhienicac gkcgqilvkg rqlqehaqrc gepqdltmng
      481 lgnteekmdl eenpdeqsei rdmfvemldd frdnhyqins iqkkqlfkhs acpfrcpncg
      541 qrfetenlvv ehmsscldqd mfksaimeen erdhrrkhfc nlcgkgfyqr chlrehytvh
      601 tkekqfvcqt cgkqflrerq lrlhndmhkg maryvcsicd qgnfrkhdhv rhmishlsag
      661 eticqvcfqi fpnneqleqh mdvhlytcgi cgakfnlrkd mrshynakhl krt
//
LOCUS       XP_016876584             713 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger and BTB domain-containing protein 1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_016876584
VERSION     XP_016876584.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021095.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..713
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..713
                     /product="zinc finger and BTB domain-containing protein 1
                     isoform X1"
                     /calculated_mol_wt=81885
     Region          3..116
                     /region_name="BTB_POZ_ZBTB1"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 1 (ZBTB1); cd18192"
                     /db_xref="CDD:349501"
     Region          536..574
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          580..600
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(585,587,589,591..592,595..596,599,613,615,619..620,
                     623..624,627,641,644,646,648..649,651..652,655)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          608..628
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          636..656
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          664..684
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          688..709
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275371"
     CDS             1..713
                     /gene="ZBTB1"
                     /gene_synonym="ZNF909"
                     /coded_by="XM_017021095.2:332..2473"
                     /db_xref="GeneID:22890"
                     /db_xref="HGNC:HGNC:20259"
                     /db_xref="MIM:616578"
ORIGIN      
        1 makpshssyv lqqlnnqrew gflcdcciai ddiyfqahka vlaacssyfr mffmnhqhst
       61 aqlnlsnmki saecfdlilq fmylgkimta pssfeqfkva mnylqlynvp dclediqdad
      121 cssskcsssa sskqnskmif gvrmyedtva rngneanrwc aepsstvntp hnreadeesl
      181 qlgnfpeplf dvckkssvsk lstpkervsr rfgrsftcds cgfgfscekl ldehvltctn
      241 rhlyqntrsy hrivdirdgk dsnikaefge kdssktfsaq tdkyrgdtsq aaddsasttg
      301 srksstvese iaseeksraa erkriiikme pediptdelk dfniikvtdk dcnestdnde
      361 ledepeepfy ryyveedvsi kksgrktlkp rmsvsaderg glenmrppnn sspvqedaen
      421 ascelcglti teedlsshyl akhienicac gkcgqilvkg rqlqehaqrc gepqdltmng
      481 lgnteekmdl eenpdeqsei rdmfvemldd frdnhyqins iqkkqlfkhs acpfrcpncg
      541 qrfetenlvv ehmsscldqd mfksaimeen erdhrrkhfc nlcgkgfyqr chlrehytvh
      601 tkekqfvcqt cgkqflrerq lrlhndmhkg maryvcsicd qgnfrkhdhv rhmishlsag
      661 eticqvcfqi fpnneqleqh mdvhlytcgi cgakfnlrkd mrshynakhl krt
//
LOCUS       XP_047287058             713 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger and BTB domain-containing protein 1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_047287058
VERSION     XP_047287058.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431102.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..713
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..713
                     /product="zinc finger and BTB domain-containing protein 1
                     isoform X1"
                     /calculated_mol_wt=81885
     Region          3..116
                     /region_name="BTB_POZ_ZBTB1"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 1 (ZBTB1); cd18192"
                     /db_xref="CDD:349501"
     Region          536..574
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          580..600
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(585,587,589,591..592,595..596,599,613,615,619..620,
                     623..624,627,641,644,646,648..649,651..652,655)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          608..628
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          636..656
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          664..684
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          688..709
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275371"
     CDS             1..713
                     /gene="ZBTB1"
                     /gene_synonym="ZNF909"
                     /coded_by="XM_047431102.1:530..2671"
                     /db_xref="GeneID:22890"
                     /db_xref="HGNC:HGNC:20259"
                     /db_xref="MIM:616578"
ORIGIN      
        1 makpshssyv lqqlnnqrew gflcdcciai ddiyfqahka vlaacssyfr mffmnhqhst
       61 aqlnlsnmki saecfdlilq fmylgkimta pssfeqfkva mnylqlynvp dclediqdad
      121 cssskcsssa sskqnskmif gvrmyedtva rngneanrwc aepsstvntp hnreadeesl
      181 qlgnfpeplf dvckkssvsk lstpkervsr rfgrsftcds cgfgfscekl ldehvltctn
      241 rhlyqntrsy hrivdirdgk dsnikaefge kdssktfsaq tdkyrgdtsq aaddsasttg
      301 srksstvese iaseeksraa erkriiikme pediptdelk dfniikvtdk dcnestdnde
      361 ledepeepfy ryyveedvsi kksgrktlkp rmsvsaderg glenmrppnn sspvqedaen
      421 ascelcglti teedlsshyl akhienicac gkcgqilvkg rqlqehaqrc gepqdltmng
      481 lgnteekmdl eenpdeqsei rdmfvemldd frdnhyqins iqkkqlfkhs acpfrcpncg
      541 qrfetenlvv ehmsscldqd mfksaimeen erdhrrkhfc nlcgkgfyqr chlrehytvh
      601 tkekqfvcqt cgkqflrerq lrlhndmhkg maryvcsicd qgnfrkhdhv rhmishlsag
      661 eticqvcfqi fpnneqleqh mdvhlytcgi cgakfnlrkd mrshynakhl krt
//
LOCUS       XP_047287059             713 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger and BTB domain-containing protein 1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_047287059
VERSION     XP_047287059.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431103.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..713
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..713
                     /product="zinc finger and BTB domain-containing protein 1
                     isoform X1"
                     /calculated_mol_wt=81885
     Region          3..116
                     /region_name="BTB_POZ_ZBTB1"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 1 (ZBTB1); cd18192"
                     /db_xref="CDD:349501"
     Region          536..574
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          580..600
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(585,587,589,591..592,595..596,599,613,615,619..620,
                     623..624,627,641,644,646,648..649,651..652,655)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          608..628
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          636..656
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          664..684
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          688..709
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275371"
     CDS             1..713
                     /gene="ZBTB1"
                     /gene_synonym="ZNF909"
                     /coded_by="XM_047431103.1:1110..3251"
                     /db_xref="GeneID:22890"
                     /db_xref="HGNC:HGNC:20259"
                     /db_xref="MIM:616578"
ORIGIN      
        1 makpshssyv lqqlnnqrew gflcdcciai ddiyfqahka vlaacssyfr mffmnhqhst
       61 aqlnlsnmki saecfdlilq fmylgkimta pssfeqfkva mnylqlynvp dclediqdad
      121 cssskcsssa sskqnskmif gvrmyedtva rngneanrwc aepsstvntp hnreadeesl
      181 qlgnfpeplf dvckkssvsk lstpkervsr rfgrsftcds cgfgfscekl ldehvltctn
      241 rhlyqntrsy hrivdirdgk dsnikaefge kdssktfsaq tdkyrgdtsq aaddsasttg
      301 srksstvese iaseeksraa erkriiikme pediptdelk dfniikvtdk dcnestdnde
      361 ledepeepfy ryyveedvsi kksgrktlkp rmsvsaderg glenmrppnn sspvqedaen
      421 ascelcglti teedlsshyl akhienicac gkcgqilvkg rqlqehaqrc gepqdltmng
      481 lgnteekmdl eenpdeqsei rdmfvemldd frdnhyqins iqkkqlfkhs acpfrcpncg
      541 qrfetenlvv ehmsscldqd mfksaimeen erdhrrkhfc nlcgkgfyqr chlrehytvh
      601 tkekqfvcqt cgkqflrerq lrlhndmhkg maryvcsicd qgnfrkhdhv rhmishlsag
      661 eticqvcfqi fpnneqleqh mdvhlytcgi cgakfnlrkd mrshynakhl krt
//
LOCUS       XP_047287060             713 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger and BTB domain-containing protein 1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_047287060
VERSION     XP_047287060.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431104.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..713
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..713
                     /product="zinc finger and BTB domain-containing protein 1
                     isoform X1"
                     /calculated_mol_wt=81885
     Region          3..116
                     /region_name="BTB_POZ_ZBTB1"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 1 (ZBTB1); cd18192"
                     /db_xref="CDD:349501"
     Region          536..574
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          580..600
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(585,587,589,591..592,595..596,599,613,615,619..620,
                     623..624,627,641,644,646,648..649,651..652,655)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          608..628
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          636..656
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          664..684
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          688..709
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275371"
     CDS             1..713
                     /gene="ZBTB1"
                     /gene_synonym="ZNF909"
                     /coded_by="XM_047431104.1:489..2630"
                     /db_xref="GeneID:22890"
                     /db_xref="HGNC:HGNC:20259"
                     /db_xref="MIM:616578"
ORIGIN      
        1 makpshssyv lqqlnnqrew gflcdcciai ddiyfqahka vlaacssyfr mffmnhqhst
       61 aqlnlsnmki saecfdlilq fmylgkimta pssfeqfkva mnylqlynvp dclediqdad
      121 cssskcsssa sskqnskmif gvrmyedtva rngneanrwc aepsstvntp hnreadeesl
      181 qlgnfpeplf dvckkssvsk lstpkervsr rfgrsftcds cgfgfscekl ldehvltctn
      241 rhlyqntrsy hrivdirdgk dsnikaefge kdssktfsaq tdkyrgdtsq aaddsasttg
      301 srksstvese iaseeksraa erkriiikme pediptdelk dfniikvtdk dcnestdnde
      361 ledepeepfy ryyveedvsi kksgrktlkp rmsvsaderg glenmrppnn sspvqedaen
      421 ascelcglti teedlsshyl akhienicac gkcgqilvkg rqlqehaqrc gepqdltmng
      481 lgnteekmdl eenpdeqsei rdmfvemldd frdnhyqins iqkkqlfkhs acpfrcpncg
      541 qrfetenlvv ehmsscldqd mfksaimeen erdhrrkhfc nlcgkgfyqr chlrehytvh
      601 tkekqfvcqt cgkqflrerq lrlhndmhkg maryvcsicd qgnfrkhdhv rhmishlsag
      661 eticqvcfqi fpnneqleqh mdvhlytcgi cgakfnlrkd mrshynakhl krt
//
LOCUS       XP_047287061             713 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger and BTB domain-containing protein 1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_047287061
VERSION     XP_047287061.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431105.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..713
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..713
                     /product="zinc finger and BTB domain-containing protein 1
                     isoform X1"
                     /calculated_mol_wt=81885
     Region          3..116
                     /region_name="BTB_POZ_ZBTB1"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 1 (ZBTB1); cd18192"
                     /db_xref="CDD:349501"
     Region          536..574
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          580..600
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(585,587,589,591..592,595..596,599,613,615,619..620,
                     623..624,627,641,644,646,648..649,651..652,655)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          608..628
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          636..656
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          664..684
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          688..709
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275371"
     CDS             1..713
                     /gene="ZBTB1"
                     /gene_synonym="ZNF909"
                     /coded_by="XM_047431105.1:688..2829"
                     /db_xref="GeneID:22890"
                     /db_xref="HGNC:HGNC:20259"
                     /db_xref="MIM:616578"
ORIGIN      
        1 makpshssyv lqqlnnqrew gflcdcciai ddiyfqahka vlaacssyfr mffmnhqhst
       61 aqlnlsnmki saecfdlilq fmylgkimta pssfeqfkva mnylqlynvp dclediqdad
      121 cssskcsssa sskqnskmif gvrmyedtva rngneanrwc aepsstvntp hnreadeesl
      181 qlgnfpeplf dvckkssvsk lstpkervsr rfgrsftcds cgfgfscekl ldehvltctn
      241 rhlyqntrsy hrivdirdgk dsnikaefge kdssktfsaq tdkyrgdtsq aaddsasttg
      301 srksstvese iaseeksraa erkriiikme pediptdelk dfniikvtdk dcnestdnde
      361 ledepeepfy ryyveedvsi kksgrktlkp rmsvsaderg glenmrppnn sspvqedaen
      421 ascelcglti teedlsshyl akhienicac gkcgqilvkg rqlqehaqrc gepqdltmng
      481 lgnteekmdl eenpdeqsei rdmfvemldd frdnhyqins iqkkqlfkhs acpfrcpncg
      541 qrfetenlvv ehmsscldqd mfksaimeen erdhrrkhfc nlcgkgfyqr chlrehytvh
      601 tkekqfvcqt cgkqflrerq lrlhndmhkg maryvcsicd qgnfrkhdhv rhmishlsag
      661 eticqvcfqi fpnneqleqh mdvhlytcgi cgakfnlrkd mrshynakhl krt
//
LOCUS       XP_047287062             713 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger and BTB domain-containing protein 1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_047287062
VERSION     XP_047287062.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431106.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..713
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..713
                     /product="zinc finger and BTB domain-containing protein 1
                     isoform X1"
                     /calculated_mol_wt=81885
     Region          3..116
                     /region_name="BTB_POZ_ZBTB1"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 1 (ZBTB1); cd18192"
                     /db_xref="CDD:349501"
     Region          536..574
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          580..600
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(585,587,589,591..592,595..596,599,613,615,619..620,
                     623..624,627,641,644,646,648..649,651..652,655)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          608..628
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          636..656
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          664..684
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          688..709
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275371"
     CDS             1..713
                     /gene="ZBTB1"
                     /gene_synonym="ZNF909"
                     /coded_by="XM_047431106.1:262..2403"
                     /db_xref="GeneID:22890"
                     /db_xref="HGNC:HGNC:20259"
                     /db_xref="MIM:616578"
ORIGIN      
        1 makpshssyv lqqlnnqrew gflcdcciai ddiyfqahka vlaacssyfr mffmnhqhst
       61 aqlnlsnmki saecfdlilq fmylgkimta pssfeqfkva mnylqlynvp dclediqdad
      121 cssskcsssa sskqnskmif gvrmyedtva rngneanrwc aepsstvntp hnreadeesl
      181 qlgnfpeplf dvckkssvsk lstpkervsr rfgrsftcds cgfgfscekl ldehvltctn
      241 rhlyqntrsy hrivdirdgk dsnikaefge kdssktfsaq tdkyrgdtsq aaddsasttg
      301 srksstvese iaseeksraa erkriiikme pediptdelk dfniikvtdk dcnestdnde
      361 ledepeepfy ryyveedvsi kksgrktlkp rmsvsaderg glenmrppnn sspvqedaen
      421 ascelcglti teedlsshyl akhienicac gkcgqilvkg rqlqehaqrc gepqdltmng
      481 lgnteekmdl eenpdeqsei rdmfvemldd frdnhyqins iqkkqlfkhs acpfrcpncg
      541 qrfetenlvv ehmsscldqd mfksaimeen erdhrrkhfc nlcgkgfyqr chlrehytvh
      601 tkekqfvcqt cgkqflrerq lrlhndmhkg maryvcsicd qgnfrkhdhv rhmishlsag
      661 eticqvcfqi fpnneqleqh mdvhlytcgi cgakfnlrkd mrshynakhl krt
//
LOCUS       XP_047287063             644 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger and BTB domain-containing protein 1 isoform X2 [Homo
            sapiens].
ACCESSION   XP_047287063
VERSION     XP_047287063.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431107.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..644
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..644
                     /product="zinc finger and BTB domain-containing protein 1
                     isoform X2"
                     /calculated_mol_wt=73552
     Region          3..116
                     /region_name="BTB_POZ_ZBTB1"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 1 (ZBTB1); cd18192"
                     /db_xref="CDD:349501"
     Region          536..574
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(541,543,545,547..548,551..552,573,585,587,591..592,
                     595..596,599,613,615,617,619..620,623..624,627)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          580..600
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          608..628
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..644
                     /gene="ZBTB1"
                     /gene_synonym="ZNF909"
                     /coded_by="XM_047431107.1:682..2616"
                     /db_xref="GeneID:22890"
                     /db_xref="HGNC:HGNC:20259"
                     /db_xref="MIM:616578"
ORIGIN      
        1 makpshssyv lqqlnnqrew gflcdcciai ddiyfqahka vlaacssyfr mffmnhqhst
       61 aqlnlsnmki saecfdlilq fmylgkimta pssfeqfkva mnylqlynvp dclediqdad
      121 cssskcsssa sskqnskmif gvrmyedtva rngneanrwc aepsstvntp hnreadeesl
      181 qlgnfpeplf dvckkssvsk lstpkervsr rfgrsftcds cgfgfscekl ldehvltctn
      241 rhlyqntrsy hrivdirdgk dsnikaefge kdssktfsaq tdkyrgdtsq aaddsasttg
      301 srksstvese iaseeksraa erkriiikme pediptdelk dfniikvtdk dcnestdnde
      361 ledepeepfy ryyveedvsi kksgrktlkp rmsvsaderg glenmrppnn sspvqedaen
      421 ascelcglti teedlsshyl akhienicac gkcgqilvkg rqlqehaqrc gepqdltmng
      481 lgnteekmdl eenpdeqsei rdmfvemldd frdnhyqins iqkkqlfkhs acpfrcpncg
      541 qrfetenlvv ehmsscldqd mfksaimeen erdhrrkhfc nlcgkgfyqr chlrehytvh
      601 tkekqfvcqt cgkqflrerq lrlhndmhkg masgeigpsk pvek
//
LOCUS       XP_047287064             644 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger and BTB domain-containing protein 1 isoform X2 [Homo
            sapiens].
ACCESSION   XP_047287064
VERSION     XP_047287064.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431108.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..644
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..644
                     /product="zinc finger and BTB domain-containing protein 1
                     isoform X2"
                     /calculated_mol_wt=73552
     Region          3..116
                     /region_name="BTB_POZ_ZBTB1"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 1 (ZBTB1); cd18192"
                     /db_xref="CDD:349501"
     Region          536..574
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(541,543,545,547..548,551..552,573,585,587,591..592,
                     595..596,599,613,615,617,619..620,623..624,627)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          580..600
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          608..628
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..644
                     /gene="ZBTB1"
                     /gene_synonym="ZNF909"
                     /coded_by="XM_047431108.1:632..2566"
                     /db_xref="GeneID:22890"
                     /db_xref="HGNC:HGNC:20259"
                     /db_xref="MIM:616578"
ORIGIN      
        1 makpshssyv lqqlnnqrew gflcdcciai ddiyfqahka vlaacssyfr mffmnhqhst
       61 aqlnlsnmki saecfdlilq fmylgkimta pssfeqfkva mnylqlynvp dclediqdad
      121 cssskcsssa sskqnskmif gvrmyedtva rngneanrwc aepsstvntp hnreadeesl
      181 qlgnfpeplf dvckkssvsk lstpkervsr rfgrsftcds cgfgfscekl ldehvltctn
      241 rhlyqntrsy hrivdirdgk dsnikaefge kdssktfsaq tdkyrgdtsq aaddsasttg
      301 srksstvese iaseeksraa erkriiikme pediptdelk dfniikvtdk dcnestdnde
      361 ledepeepfy ryyveedvsi kksgrktlkp rmsvsaderg glenmrppnn sspvqedaen
      421 ascelcglti teedlsshyl akhienicac gkcgqilvkg rqlqehaqrc gepqdltmng
      481 lgnteekmdl eenpdeqsei rdmfvemldd frdnhyqins iqkkqlfkhs acpfrcpncg
      541 qrfetenlvv ehmsscldqd mfksaimeen erdhrrkhfc nlcgkgfyqr chlrehytvh
      601 tkekqfvcqt cgkqflrerq lrlhndmhkg masgeigpsk pvek
//
LOCUS       XP_047287066             644 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger and BTB domain-containing protein 1 isoform X2 [Homo
            sapiens].
ACCESSION   XP_047287066
VERSION     XP_047287066.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431110.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..644
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..644
                     /product="zinc finger and BTB domain-containing protein 1
                     isoform X2"
                     /calculated_mol_wt=73552
     Region          3..116
                     /region_name="BTB_POZ_ZBTB1"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 1 (ZBTB1); cd18192"
                     /db_xref="CDD:349501"
     Region          536..574
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(541,543,545,547..548,551..552,573,585,587,591..592,
                     595..596,599,613,615,617,619..620,623..624,627)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          580..600
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          608..628
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..644
                     /gene="ZBTB1"
                     /gene_synonym="ZNF909"
                     /coded_by="XM_047431110.1:348..2282"
                     /db_xref="GeneID:22890"
                     /db_xref="HGNC:HGNC:20259"
                     /db_xref="MIM:616578"
ORIGIN      
        1 makpshssyv lqqlnnqrew gflcdcciai ddiyfqahka vlaacssyfr mffmnhqhst
       61 aqlnlsnmki saecfdlilq fmylgkimta pssfeqfkva mnylqlynvp dclediqdad
      121 cssskcsssa sskqnskmif gvrmyedtva rngneanrwc aepsstvntp hnreadeesl
      181 qlgnfpeplf dvckkssvsk lstpkervsr rfgrsftcds cgfgfscekl ldehvltctn
      241 rhlyqntrsy hrivdirdgk dsnikaefge kdssktfsaq tdkyrgdtsq aaddsasttg
      301 srksstvese iaseeksraa erkriiikme pediptdelk dfniikvtdk dcnestdnde
      361 ledepeepfy ryyveedvsi kksgrktlkp rmsvsaderg glenmrppnn sspvqedaen
      421 ascelcglti teedlsshyl akhienicac gkcgqilvkg rqlqehaqrc gepqdltmng
      481 lgnteekmdl eenpdeqsei rdmfvemldd frdnhyqins iqkkqlfkhs acpfrcpncg
      541 qrfetenlvv ehmsscldqd mfksaimeen erdhrrkhfc nlcgkgfyqr chlrehytvh
      601 tkekqfvcqt cgkqflrerq lrlhndmhkg masgeigpsk pvek
//
LOCUS       XP_047287067             644 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger and BTB domain-containing protein 1 isoform X2 [Homo
            sapiens].
ACCESSION   XP_047287067
VERSION     XP_047287067.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431111.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..644
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..644
                     /product="zinc finger and BTB domain-containing protein 1
                     isoform X2"
                     /calculated_mol_wt=73552
     Region          3..116
                     /region_name="BTB_POZ_ZBTB1"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 1 (ZBTB1); cd18192"
                     /db_xref="CDD:349501"
     Region          536..574
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(541,543,545,547..548,551..552,573,585,587,591..592,
                     595..596,599,613,615,617,619..620,623..624,627)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          580..600
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          608..628
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..644
                     /gene="ZBTB1"
                     /gene_synonym="ZNF909"
                     /coded_by="XM_047431111.1:278..2212"
                     /db_xref="GeneID:22890"
                     /db_xref="HGNC:HGNC:20259"
                     /db_xref="MIM:616578"
ORIGIN      
        1 makpshssyv lqqlnnqrew gflcdcciai ddiyfqahka vlaacssyfr mffmnhqhst
       61 aqlnlsnmki saecfdlilq fmylgkimta pssfeqfkva mnylqlynvp dclediqdad
      121 cssskcsssa sskqnskmif gvrmyedtva rngneanrwc aepsstvntp hnreadeesl
      181 qlgnfpeplf dvckkssvsk lstpkervsr rfgrsftcds cgfgfscekl ldehvltctn
      241 rhlyqntrsy hrivdirdgk dsnikaefge kdssktfsaq tdkyrgdtsq aaddsasttg
      301 srksstvese iaseeksraa erkriiikme pediptdelk dfniikvtdk dcnestdnde
      361 ledepeepfy ryyveedvsi kksgrktlkp rmsvsaderg glenmrppnn sspvqedaen
      421 ascelcglti teedlsshyl akhienicac gkcgqilvkg rqlqehaqrc gepqdltmng
      481 lgnteekmdl eenpdeqsei rdmfvemldd frdnhyqins iqkkqlfkhs acpfrcpncg
      541 qrfetenlvv ehmsscldqd mfksaimeen erdhrrkhfc nlcgkgfyqr chlrehytvh
      601 tkekqfvcqt cgkqflrerq lrlhndmhkg masgeigpsk pvek
//
LOCUS       XP_047287068             430 aa            linear   PRI 05-AUG-2025
DEFINITION  SNW domain-containing protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047287068
VERSION     XP_047287068.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431112.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..430
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..430
                     /product="SNW domain-containing protein 1 isoform X1"
                     /calculated_mol_wt=48894
     Region          178..334
                     /region_name="SKIP_SNW"
                     /note="SKIP/SNW domain; pfam02731"
                     /db_xref="CDD:460666"
     CDS             1..430
                     /gene="SNW1"
                     /gene_synonym="Bx42; FUN20; NCOA-62; Prp45; PRPF45; SKIIP;
                     SKIP; SKIP1"
                     /coded_by="XM_047431112.1:30..1322"
                     /db_xref="GeneID:22938"
                     /db_xref="HGNC:HGNC:16696"
                     /db_xref="MIM:603055"
ORIGIN      
        1 maltsflpap tqlsqdqlea eekarsqrsr qtslvssrre pppygyrkgw iprlledfgd
       61 ggafpeihva qypldmgrkk kmsnalaiqv dsegkikyda iarqgqskdk viyskytdlv
      121 pkevmnaddp dlqrpdeeai keitektrva leksvsqkva aampvraadk lapaqyiryt
      181 psqqgvafns gakqrvirmv emqkdpmepp rfkinkkipr gppsppapvm hspsrkmtvk
      241 eqqewkippc isnwknakgy tipldkrlaa dgrglqtvhi nenfaklaea lyiadrkare
      301 avemraqver kmaqkekekh eeklremaqk arerragikt hvekgrnfre mkigisvkll
      361 lsvflilglp mkfsmtkgss tnprvwtvdl qvekmkfimf mikpgevvki wprvfigpvk
      421 iwtrtcmvmt
//
LOCUS       XP_005267472            1340 aa            linear   PRI 05-AUG-2025
DEFINITION  apoptotic chromatin condensation inducer in the nucleus isoform X1
            [Homo sapiens].
ACCESSION   XP_005267472
VERSION     XP_005267472.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267415.5
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 3% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1340
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1340
                     /product="apoptotic chromatin condensation inducer in the
                     nucleus isoform X1"
                     /calculated_mol_wt=151660
     Region          72..106
                     /region_name="SAP"
                     /note="Putative DNA-binding (bihelical) motif predicted to
                     be involved in chromosomal organisation; smart00513"
                     /db_xref="CDD:128789"
     Region          <210..413
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          1010..1096
                     /region_name="RRM_ACINU"
                     /note="RNA recognition motif (RRM) found in apoptotic
                     chromatin condensation inducer in the nucleus (acinus) and
                     similar proteins; cd12432"
                     /db_xref="CDD:409866"
     Region          <1205..1235
                     /region_name="RSB_motif"
                     /note="RNSP1-SAP18 binding (RSB) motif; pfam16294"
                     /db_xref="CDD:465085"
     CDS             1..1340
                     /gene="ACIN1"
                     /gene_synonym="ACINUS; ACN; fSAP152"
                     /coded_by="XM_005267415.5:329..4351"
                     /db_xref="GeneID:22985"
                     /db_xref="HGNC:HGNC:17066"
                     /db_xref="MIM:604562"
ORIGIN      
        1 mwrrkhprts ggtrgvlsgn rgveygsgrg hlgtfegrwr klpkmpeavg tdpstsrkma
       61 eleevtldgk plqalrvtdl kaaleqrgla ksgqksalvk rlkgalmlen lqkhstphaa
      121 fqpnsqigee msqnsfikqy lekqqellrq rlereareaa eleeasaese demihpegva
      181 sllppdfqss lerpelelsr hsprksssis eekgdsddek prkgerrssr vrqaraakls
      241 egsqpaeeee dqetpsrnlr vradrnlkte eeeeeeeeee eddeeeegdd egqksreapi
      301 lkefkeegee iprvkpeemm derpktrsqe qevlerggrf trsqeearks hlarqqqeke
      361 mkttspleee ereikssqgl kekskspspp rltedrkkas lvalpeqtas eeetpppllt
      421 keassppphp qlhseeeiep megpapavli qlsppntdad trellvsqht vqlvgglspl
      481 sspsdtkaes paekvpeesv lplvqkstla dysaqkdlep esdrsaqplp lkieelalak
      541 giteeclkqp sleqkegrra shtllpshrl kqsadssssr sssssssssr srsrspdssg
      601 srshsplrsk qrdvaqarth anprgrpkmg srstsesrsr srsrsrsass nsrkslspgv
      661 srdsstsyte tkdpssgqev atppvpqlqv cepkertsts sssvqarrls qpesaekhvt
      721 qrlqpergsp kkceaeeaep paatqpqtse tqtshlpese rihhtveeke evtmdtsenr
      781 pendvpeppm piadqvsndd rpegsvedee kkesslpksf krkisvvstk gvpagnsdte
      841 ggqpgrkrrw gastattqkk psisittesl kslipdikpl agqeavvdlh addsrisede
      901 terngddgth dkglkicrtv tqvvpaegqe ngqreeeeee kepeaeppvp pqvsvevalp
      961 ppaehevkkv tlgdtltrrs isqqksgvsi tiddpvrtaq vpspprgkis nivhisnlvr
     1021 pftlgqlkel lgrtgtlvee afwidkiksh cfvtystvee avatrtalhg vkwpqsnpkf
     1081 lcadyaeqde ldyhrgllvd rpsetkteeq giprplhppp pppvqppqhp raeqreqera
     1141 vreqwaerer emerrertrs erewdrdkvr egprsrsrsr drrrkeraks kekksekkek
     1201 aqeeppakll ddlfrktkaa pciywlpltd sqivqkeaer aerakerekr rkeqeeeeqk
     1261 erekeaerer nrqlerekrr ehsrerdrer erererdrgd rdrdrerdre rgrerdrrdt
     1321 krhsrsrsrs tpvrdrggrr
//
LOCUS       XP_005267473            1329 aa            linear   PRI 05-AUG-2025
DEFINITION  apoptotic chromatin condensation inducer in the nucleus isoform X2
            [Homo sapiens].
ACCESSION   XP_005267473
VERSION     XP_005267473.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267416.5
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 3% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1329
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1329
                     /product="apoptotic chromatin condensation inducer in the
                     nucleus isoform X2"
                     /calculated_mol_wt=150497
     Region          72..106
                     /region_name="SAP"
                     /note="Putative DNA-binding (bihelical) motif predicted to
                     be involved in chromosomal organisation; smart00513"
                     /db_xref="CDD:128789"
     Region          <210..413
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          999..1085
                     /region_name="RRM_ACINU"
                     /note="RNA recognition motif (RRM) found in apoptotic
                     chromatin condensation inducer in the nucleus (acinus) and
                     similar proteins; cd12432"
                     /db_xref="CDD:409866"
     Region          <1194..1224
                     /region_name="RSB_motif"
                     /note="RNSP1-SAP18 binding (RSB) motif; pfam16294"
                     /db_xref="CDD:465085"
     CDS             1..1329
                     /gene="ACIN1"
                     /gene_synonym="ACINUS; ACN; fSAP152"
                     /coded_by="XM_005267416.5:329..4318"
                     /db_xref="GeneID:22985"
                     /db_xref="HGNC:HGNC:17066"
                     /db_xref="MIM:604562"
ORIGIN      
        1 mwrrkhprts ggtrgvlsgn rgveygsgrg hlgtfegrwr klpkmpeavg tdpstsrkma
       61 eleevtldgk plqalrvtdl kaaleqrgla ksgqksalvk rlkgalmlen lqkhstphaa
      121 fqpnsqigee msqnsfikqy lekqqellrq rlereareaa eleeasaese demihpegva
      181 sllppdfqss lerpelelsr hsprksssis eekgdsddek prkgerrssr vrqaraakls
      241 egsqpaeeee dqetpsrnlr vradrnlkte eeeeeeeeee eddeeeegdd egqksreapi
      301 lkefkeegee iprvkpeemm derpktrsqe qevlerggrf trsqeearks hlarqqqeke
      361 mkttspleee ereikssqgl kekskspspp rltedrkkas lvalpeqtas eeetpppllt
      421 keassppphp qlhseeeiep megpapavli qlsppntdad trellvsqht vqlvgglspl
      481 sspsdtkaes paekvpeesv lplvqkstla dysaqkdlep esdrsaqplp lkieelalak
      541 giteeclkqp sleqkegrra shtllpshrl kqsadssssr sssssssssr srsrspdssg
      601 srshsplrsk qrdvaqarth anprgrpkmg srstsesrsr srsrsrsass nsrkslspgv
      661 srdsstsyte tkdpssgqev atppvpqlqv cepkertsts sssvqarrls qpesaekhvt
      721 qrlqpergsp kkceaeeaep paatqpqtse tqtshlpese rihhtveeke evtmdtsenr
      781 pendvpeppm piadqvsndd rpegsvedee kkesslpksf krkisvvsat kgvpagnsdt
      841 eggqpgrkrr wgastattqk kpsisittes lkeavvdlha ddsrisedet erngddgthd
      901 kglkicrtvt qvvpaegqen gqreeeeeek epeaeppvpp qvsvevalpp paehevkkvt
      961 lgdtltrrsi sqqksgvsit iddpvrtaqv pspprgkisn ivhisnlvrp ftlgqlkell
     1021 grtgtlveea fwidkikshc fvtystveea vatrtalhgv kwpqsnpkfl cadyaeqdel
     1081 dyhrgllvdr psetkteeqg iprplhpppp ppvqppqhpr aeqreqerav reqwaerere
     1141 merrertrse rewdrdkvre gprsrsrsrd rrrkeraksk ekksekkeka qeeppaklld
     1201 dlfrktkaap ciywlpltds qivqkeaera erakerekrr keqeeeeqke rekeaerern
     1261 rqlerekrre hsrerdrere rererdrgdr drdrerdrer grerdrrdtk rhsrsrsrst
     1321 pvrdrggrr
//
LOCUS       XP_047287069            1300 aa            linear   PRI 05-AUG-2025
DEFINITION  apoptotic chromatin condensation inducer in the nucleus isoform X3
            [Homo sapiens].
ACCESSION   XP_047287069
VERSION     XP_047287069.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431113.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 3% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1300
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1300
                     /product="apoptotic chromatin condensation inducer in the
                     nucleus isoform X3"
                     /calculated_mol_wt=147161
     Region          72..106
                     /region_name="SAP"
                     /note="Putative DNA-binding (bihelical) motif predicted to
                     be involved in chromosomal organisation; smart00513"
                     /db_xref="CDD:128789"
     Region          <141..373
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          970..1056
                     /region_name="RRM_ACINU"
                     /note="RNA recognition motif (RRM) found in apoptotic
                     chromatin condensation inducer in the nucleus (acinus) and
                     similar proteins; cd12432"
                     /db_xref="CDD:409866"
     Region          <1165..1195
                     /region_name="RSB_motif"
                     /note="RNSP1-SAP18 binding (RSB) motif; pfam16294"
                     /db_xref="CDD:465085"
     CDS             1..1300
                     /gene="ACIN1"
                     /gene_synonym="ACINUS; ACN; fSAP152"
                     /coded_by="XM_047431113.1:329..4231"
                     /db_xref="GeneID:22985"
                     /db_xref="HGNC:HGNC:17066"
                     /db_xref="MIM:604562"
ORIGIN      
        1 mwrrkhprts ggtrgvlsgn rgveygsgrg hlgtfegrwr klpkmpeavg tdpstsrkma
       61 eleevtldgk plqalrvtdl kaaleqrgla ksgqksalvk rlkgalmlen lqkhstphaa
      121 fqpnsqigee msqnsfikqy lekqqellrq rlereareaa elegksssis eekgdsddek
      181 prkgerrssr vrqaraakls egsqpaeeee dqetpsrnlr vradrnlkte eeeeeeeeee
      241 eddeeeegdd egqksreapi lkefkeegee iprvkpeemm derpktrsqe qevlerggrf
      301 trsqeearks hlarqqqeke mkttspleee ereikssqgl kekskspspp rltedrkkas
      361 lvalpeqtas eeetpppllt keassppphp qlhseeeiep megpapavli qlsppntdad
      421 trellvsqht vqlvgglspl sspsdtkaes paekvpeesv lplvqkstla dysaqkdlep
      481 esdrsaqplp lkieelalak giteeclkqp sleqkegrra shtllpshrl kqsadssssr
      541 sssssssssr srsrspdssg srshsplrsk qrdvaqarth anprgrpkmg srstsesrsr
      601 srsrsrsass nsrkslspgv srdsstsyte tkdpssgqev atppvpqlqv cepkertsts
      661 sssvqarrls qpesaekhvt qrlqpergsp kkceaeeaep paatqpqtse tqtshlpese
      721 rihhtveeke evtmdtsenr pendvpeppm piadqvsndd rpegsvedee kkesslpksf
      781 krkisvvstk gvpagnsdte ggqpgrkrrw gastattqkk psisittesl kslipdikpl
      841 agqeavvdlh addsrisede terngddgth dkglkicrtv tqvvpaegqe ngqreeeeee
      901 kepeaeppvp pqvsvevalp ppaehevkkv tlgdtltrrs isqqksgvsi tiddpvrtaq
      961 vpspprgkis nivhisnlvr pftlgqlkel lgrtgtlvee afwidkiksh cfvtystvee
     1021 avatrtalhg vkwpqsnpkf lcadyaeqde ldyhrgllvd rpsetkteeq giprplhppp
     1081 pppvqppqhp raeqreqera vreqwaerer emerrertrs erewdrdkvr egprsrsrsr
     1141 drrrkeraks kekksekkek aqeeppakll ddlfrktkaa pciywlpltd sqivqkeaer
     1201 aerakerekr rkeqeeeeqk erekeaerer nrqlerekrr ehsrerdrer erererdrgd
     1261 rdrdrerdre rgrerdrrdt krhsrsrsrs tpvrdrggrr
//
LOCUS       XP_047287070            1289 aa            linear   PRI 05-AUG-2025
DEFINITION  apoptotic chromatin condensation inducer in the nucleus isoform X4
            [Homo sapiens].
ACCESSION   XP_047287070
VERSION     XP_047287070.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431114.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 3% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1289
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1289
                     /product="apoptotic chromatin condensation inducer in the
                     nucleus isoform X4"
                     /calculated_mol_wt=145999
     Region          72..106
                     /region_name="SAP"
                     /note="Putative DNA-binding (bihelical) motif predicted to
                     be involved in chromosomal organisation; smart00513"
                     /db_xref="CDD:128789"
     Region          <141..373
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          959..1045
                     /region_name="RRM_ACINU"
                     /note="RNA recognition motif (RRM) found in apoptotic
                     chromatin condensation inducer in the nucleus (acinus) and
                     similar proteins; cd12432"
                     /db_xref="CDD:409866"
     Region          <1154..1184
                     /region_name="RSB_motif"
                     /note="RNSP1-SAP18 binding (RSB) motif; pfam16294"
                     /db_xref="CDD:465085"
     CDS             1..1289
                     /gene="ACIN1"
                     /gene_synonym="ACINUS; ACN; fSAP152"
                     /coded_by="XM_047431114.1:329..4198"
                     /db_xref="GeneID:22985"
                     /db_xref="HGNC:HGNC:17066"
                     /db_xref="MIM:604562"
ORIGIN      
        1 mwrrkhprts ggtrgvlsgn rgveygsgrg hlgtfegrwr klpkmpeavg tdpstsrkma
       61 eleevtldgk plqalrvtdl kaaleqrgla ksgqksalvk rlkgalmlen lqkhstphaa
      121 fqpnsqigee msqnsfikqy lekqqellrq rlereareaa elegksssis eekgdsddek
      181 prkgerrssr vrqaraakls egsqpaeeee dqetpsrnlr vradrnlkte eeeeeeeeee
      241 eddeeeegdd egqksreapi lkefkeegee iprvkpeemm derpktrsqe qevlerggrf
      301 trsqeearks hlarqqqeke mkttspleee ereikssqgl kekskspspp rltedrkkas
      361 lvalpeqtas eeetpppllt keassppphp qlhseeeiep megpapavli qlsppntdad
      421 trellvsqht vqlvgglspl sspsdtkaes paekvpeesv lplvqkstla dysaqkdlep
      481 esdrsaqplp lkieelalak giteeclkqp sleqkegrra shtllpshrl kqsadssssr
      541 sssssssssr srsrspdssg srshsplrsk qrdvaqarth anprgrpkmg srstsesrsr
      601 srsrsrsass nsrkslspgv srdsstsyte tkdpssgqev atppvpqlqv cepkertsts
      661 sssvqarrls qpesaekhvt qrlqpergsp kkceaeeaep paatqpqtse tqtshlpese
      721 rihhtveeke evtmdtsenr pendvpeppm piadqvsndd rpegsvedee kkesslpksf
      781 krkisvvsat kgvpagnsdt eggqpgrkrr wgastattqk kpsisittes lkeavvdlha
      841 ddsrisedet erngddgthd kglkicrtvt qvvpaegqen gqreeeeeek epeaeppvpp
      901 qvsvevalpp paehevkkvt lgdtltrrsi sqqksgvsit iddpvrtaqv pspprgkisn
      961 ivhisnlvrp ftlgqlkell grtgtlveea fwidkikshc fvtystveea vatrtalhgv
     1021 kwpqsnpkfl cadyaeqdel dyhrgllvdr psetkteeqg iprplhpppp ppvqppqhpr
     1081 aeqreqerav reqwaerere merrertrse rewdrdkvre gprsrsrsrd rrrkeraksk
     1141 ekksekkeka qeeppaklld dlfrktkaap ciywlpltds qivqkeaera erakerekrr
     1201 keqeeeeqke rekeaerern rqlerekrre hsrerdrere rererdrgdr drdrerdrer
     1261 grerdrrdtk rhsrsrsrst pvrdrggrr
//
LOCUS       XP_047287071            1288 aa            linear   PRI 05-AUG-2025
DEFINITION  apoptotic chromatin condensation inducer in the nucleus isoform X5
            [Homo sapiens].
ACCESSION   XP_047287071
VERSION     XP_047287071.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431115.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 3% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1288
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1288
                     /product="apoptotic chromatin condensation inducer in the
                     nucleus isoform X5"
                     /calculated_mol_wt=145927
     Region          72..106
                     /region_name="SAP"
                     /note="Putative DNA-binding (bihelical) motif predicted to
                     be involved in chromosomal organisation; smart00513"
                     /db_xref="CDD:128789"
     Region          <141..373
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          958..1044
                     /region_name="RRM_ACINU"
                     /note="RNA recognition motif (RRM) found in apoptotic
                     chromatin condensation inducer in the nucleus (acinus) and
                     similar proteins; cd12432"
                     /db_xref="CDD:409866"
     Region          <1153..1183
                     /region_name="RSB_motif"
                     /note="RNSP1-SAP18 binding (RSB) motif; pfam16294"
                     /db_xref="CDD:465085"
     CDS             1..1288
                     /gene="ACIN1"
                     /gene_synonym="ACINUS; ACN; fSAP152"
                     /coded_by="XM_047431115.1:329..4195"
                     /db_xref="GeneID:22985"
                     /db_xref="HGNC:HGNC:17066"
                     /db_xref="MIM:604562"
ORIGIN      
        1 mwrrkhprts ggtrgvlsgn rgveygsgrg hlgtfegrwr klpkmpeavg tdpstsrkma
       61 eleevtldgk plqalrvtdl kaaleqrgla ksgqksalvk rlkgalmlen lqkhstphaa
      121 fqpnsqigee msqnsfikqy lekqqellrq rlereareaa elegksssis eekgdsddek
      181 prkgerrssr vrqaraakls egsqpaeeee dqetpsrnlr vradrnlkte eeeeeeeeee
      241 eddeeeegdd egqksreapi lkefkeegee iprvkpeemm derpktrsqe qevlerggrf
      301 trsqeearks hlarqqqeke mkttspleee ereikssqgl kekskspspp rltedrkkas
      361 lvalpeqtas eeetpppllt keassppphp qlhseeeiep megpapavli qlsppntdad
      421 trellvsqht vqlvgglspl sspsdtkaes paekvpeesv lplvqkstla dysaqkdlep
      481 esdrsaqplp lkieelalak giteeclkqp sleqkegrra shtllpshrl kqsadssssr
      541 sssssssssr srsrspdssg srshsplrsk qrdvaqarth anprgrpkmg srstsesrsr
      601 srsrsrsass nsrkslspgv srdsstsyte tkdpssgqev atppvpqlqv cepkertsts
      661 sssvqarrls qpesaekhvt qrlqpergsp kkceaeeaep paatqpqtse tqtshlpese
      721 rihhtveeke evtmdtsenr pendvpeppm piadqvsndd rpegsvedee kkesslpksf
      781 krkisvvstk gvpagnsdte ggqpgrkrrw gastattqkk psisittesl keavvdlhad
      841 dsrisedete rngddgthdk glkicrtvtq vvpaegqeng qreeeeeeke peaeppvppq
      901 vsvevalppp aehevkkvtl gdtltrrsis qqksgvsiti ddpvrtaqvp spprgkisni
      961 vhisnlvrpf tlgqlkellg rtgtlveeaf widkikshcf vtystveeav atrtalhgvk
     1021 wpqsnpkflc adyaeqdeld yhrgllvdrp setkteeqgi prplhppppp pvqppqhpra
     1081 eqreqeravr eqwaererem errertrser ewdrdkvreg prsrsrsrdr rrkerakske
     1141 kksekkekaq eeppaklldd lfrktkaapc iywlpltdsq ivqkeaerae rakerekrrk
     1201 eqeeeeqker ekeaerernr qlerekrreh srerdrerer ererdrgdrd rdrerdrerg
     1261 rerdrrdtkr hsrsrsrstp vrdrggrr
//
LOCUS       XP_047287072            1235 aa            linear   PRI 05-AUG-2025
DEFINITION  apoptotic chromatin condensation inducer in the nucleus isoform X6
            [Homo sapiens].
ACCESSION   XP_047287072
VERSION     XP_047287072.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431116.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1235
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1235
                     /product="apoptotic chromatin condensation inducer in the
                     nucleus isoform X6"
                     /calculated_mol_wt=140184
     Region          <112..306
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          905..991
                     /region_name="RRM_ACINU"
                     /note="RNA recognition motif (RRM) found in apoptotic
                     chromatin condensation inducer in the nucleus (acinus) and
                     similar proteins; cd12432"
                     /db_xref="CDD:409866"
     Region          <1100..1130
                     /region_name="RSB_motif"
                     /note="RNSP1-SAP18 binding (RSB) motif; pfam16294"
                     /db_xref="CDD:465085"
     CDS             1..1235
                     /gene="ACIN1"
                     /gene_synonym="ACINUS; ACN; fSAP152"
                     /coded_by="XM_047431116.1:1140..4847"
                     /db_xref="GeneID:22985"
                     /db_xref="HGNC:HGNC:17066"
                     /db_xref="MIM:604562"
ORIGIN      
        1 mlenlqkhst phaafqpnsq igeemsqnsf ikqylekqqe llrqrlerea reaaeleeas
       61 aesedemihp egvasllppd fqsslerpel elsrhsprks ssiseekgds ddekprkger
      121 rssrvrqara aklsegsqpa eeeedqetps rnlrvradrn lkteeeeeee eeeeeddeee
      181 egddegqksr eapilkefke egeeiprvkp eemmderpkt rsqeqevler ggrftrsqee
      241 arkshlarqq qekemkttsp leeeereiks sqglkeksks pspprltedr kkaslvalpe
      301 qtaseeetpp plltkeassp pphpqlhsee eiepmegpap avliqlsppn tdadtrellv
      361 sqhtvqlvgg lsplsspsdt kaespaekvp eesvlplvqk stladysaqk dlepesdrsa
      421 qplplkieel alakgiteec lkqpsleqke grrashtllp shrlkqsads sssrssssss
      481 sssrsrsrsp dssgsrshsp lrskqrdvaq arthanprgr pkmgsrstse srsrsrsrsr
      541 sassnsrksl spgvsrdsst sytetkdpss gqevatppvp qlqvcepker tstssssvqa
      601 rrlsqpesae khvtqrlqpe rgspkkceae eaeppaatqp qtsetqtshl peserihhtv
      661 eekeevtmdt senrpendvp eppmpiadqv snddrpegsv edeekkessl pksfkrkisv
      721 vsatkgvpag nsdteggqpg rkrrwgasta ttqkkpsisi tteslkslip dikplagqea
      781 vvdlhaddsr isedeterng ddgthdkglk icrtvtqvvp aegqengqre eeeeekepea
      841 eppvppqvsv evalpppaeh evkkvtlgdt ltrrsisqqk sgvsitiddp vrtaqvpspp
      901 rgkisnivhi snlvrpftlg qlkellgrtg tlveeafwid kikshcfvty stveeavatr
      961 talhgvkwpq snpkflcady aeqdeldyhr gllvdrpset kteeqgiprp lhppppppvq
     1021 ppqhpraeqr eqeravreqw aereremerr ertrserewd rdkvregprs rsrsrdrrrk
     1081 erakskekks ekkekaqeep pakllddlfr ktkaapciyw lpltdsqivq keaeraerak
     1141 erekrrkeqe eeeqkereke aerernrqle rekrrehsre rdrererere rdrgdrdrdr
     1201 erdrergrer drrdtkrhsr srsrstpvrd rggrr
//
LOCUS       XP_011534872             880 aa            linear   PRI 05-AUG-2025
DEFINITION  apoptotic chromatin condensation inducer in the nucleus isoform X7
            [Homo sapiens].
ACCESSION   XP_011534872
VERSION     XP_011534872.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536570.4
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 5% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..880
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..880
                     /product="apoptotic chromatin condensation inducer in the
                     nucleus isoform X7"
                     /calculated_mol_wt=97602
     Region          72..106
                     /region_name="SAP"
                     /note="Putative DNA-binding (bihelical) motif predicted to
                     be involved in chromosomal organisation; smart00513"
                     /db_xref="CDD:128789"
     Region          <210..413
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     CDS             1..880
                     /gene="ACIN1"
                     /gene_synonym="ACINUS; ACN; fSAP152"
                     /coded_by="XM_011536570.4:329..2971"
                     /db_xref="GeneID:22985"
                     /db_xref="HGNC:HGNC:17066"
                     /db_xref="MIM:604562"
ORIGIN      
        1 mwrrkhprts ggtrgvlsgn rgveygsgrg hlgtfegrwr klpkmpeavg tdpstsrkma
       61 eleevtldgk plqalrvtdl kaaleqrgla ksgqksalvk rlkgalmlen lqkhstphaa
      121 fqpnsqigee msqnsfikqy lekqqellrq rlereareaa eleeasaese demihpegva
      181 sllppdfqss lerpelelsr hsprksssis eekgdsddek prkgerrssr vrqaraakls
      241 egsqpaeeee dqetpsrnlr vradrnlkte eeeeeeeeee eddeeeegdd egqksreapi
      301 lkefkeegee iprvkpeemm derpktrsqe qevlerggrf trsqeearks hlarqqqeke
      361 mkttspleee ereikssqgl kekskspspp rltedrkkas lvalpeqtas eeetpppllt
      421 keassppphp qlhseeeiep megpapavli qlsppntdad trellvsqht vqlvgglspl
      481 sspsdtkaes paekvpeesv lplvqkstla dysaqkdlep esdrsaqplp lkieelalak
      541 giteeclkqp sleqkegrra shtllpshrl kqsadssssr sssssssssr srsrspdssg
      601 srshsplrsk qrdvaqarth anprgrpkmg srstsesrsr srsrsrsass nsrkslspgv
      661 srdsstsyte tkdpssgqev atppvpqlqv cepkertsts sssvqarrls qpesaekhvt
      721 qrlqpergsp kkceaeeaep paatqpqtse tqtshlpese rihhtveeke evtmdtsenr
      781 pendvpeppm piadqvsndd rpegsvedee kkegakkntv lerlvlskqk tfgkgwtcii
      841 sllgtpqeel vpvlgrlptc pcpfedcglp cllqtvgipi
//
LOCUS       XP_006720144             842 aa            linear   PRI 05-AUG-2025
DEFINITION  apoptotic chromatin condensation inducer in the nucleus isoform X8
            [Homo sapiens].
ACCESSION   XP_006720144
VERSION     XP_006720144.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720081.5
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 5% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..842
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..842
                     /product="apoptotic chromatin condensation inducer in the
                     nucleus isoform X8"
                     /calculated_mol_wt=93726
     Region          72..106
                     /region_name="SAP"
                     /note="Putative DNA-binding (bihelical) motif predicted to
                     be involved in chromosomal organisation; smart00513"
                     /db_xref="CDD:128789"
     Region          <210..413
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     CDS             1..842
                     /gene="ACIN1"
                     /gene_synonym="ACINUS; ACN; fSAP152"
                     /coded_by="XM_006720081.5:329..2857"
                     /db_xref="GeneID:22985"
                     /db_xref="HGNC:HGNC:17066"
                     /db_xref="MIM:604562"
ORIGIN      
        1 mwrrkhprts ggtrgvlsgn rgveygsgrg hlgtfegrwr klpkmpeavg tdpstsrkma
       61 eleevtldgk plqalrvtdl kaaleqrgla ksgqksalvk rlkgalmlen lqkhstphaa
      121 fqpnsqigee msqnsfikqy lekqqellrq rlereareaa eleeasaese demihpegva
      181 sllppdfqss lerpelelsr hsprksssis eekgdsddek prkgerrssr vrqaraakls
      241 egsqpaeeee dqetpsrnlr vradrnlkte eeeeeeeeee eddeeeegdd egqksreapi
      301 lkefkeegee iprvkpeemm derpktrsqe qevlerggrf trsqeearks hlarqqqeke
      361 mkttspleee ereikssqgl kekskspspp rltedrkkas lvalpeqtas eeetpppllt
      421 keassppphp qlhseeeiep megpapavli qlsppntdad trellvsqht vqlvgglspl
      481 sspsdtkaes paekvpeesv lplvqkstla dysaqkdlep esdrsaqplp lkieelalak
      541 giteeclkqp sleqkegrra shtllpshrl kqsadssssr sssssssssr srsrspdssg
      601 srshsplrsk qrdvaqarth anprgrpkmg srstsesrsr srsrsrsass nsrkslspgv
      661 srdsstsyte tkdpssgqev atppvpqlqv cepkertsts sssvqarrls qpesaekhvt
      721 qrlqpergsp kkceaeeaep paatqpqtse tqtshlpese rihhtveeke evtmdtsenr
      781 pendvpeppm piadqvsndd rpegsvedee kkevllprkt lskylmygnp pvkynpaqla
      841 nr
//
LOCUS       XP_047287073             840 aa            linear   PRI 05-AUG-2025
DEFINITION  apoptotic chromatin condensation inducer in the nucleus isoform X9
            [Homo sapiens].
ACCESSION   XP_047287073
VERSION     XP_047287073.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431117.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 5% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..840
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..840
                     /product="apoptotic chromatin condensation inducer in the
                     nucleus isoform X9"
                     /calculated_mol_wt=93103
     Region          72..106
                     /region_name="SAP"
                     /note="Putative DNA-binding (bihelical) motif predicted to
                     be involved in chromosomal organisation; smart00513"
                     /db_xref="CDD:128789"
     Region          <141..373
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     CDS             1..840
                     /gene="ACIN1"
                     /gene_synonym="ACINUS; ACN; fSAP152"
                     /coded_by="XM_047431117.1:329..2851"
                     /db_xref="GeneID:22985"
                     /db_xref="HGNC:HGNC:17066"
                     /db_xref="MIM:604562"
ORIGIN      
        1 mwrrkhprts ggtrgvlsgn rgveygsgrg hlgtfegrwr klpkmpeavg tdpstsrkma
       61 eleevtldgk plqalrvtdl kaaleqrgla ksgqksalvk rlkgalmlen lqkhstphaa
      121 fqpnsqigee msqnsfikqy lekqqellrq rlereareaa elegksssis eekgdsddek
      181 prkgerrssr vrqaraakls egsqpaeeee dqetpsrnlr vradrnlkte eeeeeeeeee
      241 eddeeeegdd egqksreapi lkefkeegee iprvkpeemm derpktrsqe qevlerggrf
      301 trsqeearks hlarqqqeke mkttspleee ereikssqgl kekskspspp rltedrkkas
      361 lvalpeqtas eeetpppllt keassppphp qlhseeeiep megpapavli qlsppntdad
      421 trellvsqht vqlvgglspl sspsdtkaes paekvpeesv lplvqkstla dysaqkdlep
      481 esdrsaqplp lkieelalak giteeclkqp sleqkegrra shtllpshrl kqsadssssr
      541 sssssssssr srsrspdssg srshsplrsk qrdvaqarth anprgrpkmg srstsesrsr
      601 srsrsrsass nsrkslspgv srdsstsyte tkdpssgqev atppvpqlqv cepkertsts
      661 sssvqarrls qpesaekhvt qrlqpergsp kkceaeeaep paatqpqtse tqtshlpese
      721 rihhtveeke evtmdtsenr pendvpeppm piadqvsndd rpegsvedee kkegakkntv
      781 lerlvlskqk tfgkgwtcii sllgtpqeel vpvlgrlptc pcpfedcglp cllqtvgipi
//
LOCUS       XP_047287074             832 aa            linear   PRI 05-AUG-2025
DEFINITION  apoptotic chromatin condensation inducer in the nucleus isoform X10
            [Homo sapiens].
ACCESSION   XP_047287074
VERSION     XP_047287074.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431118.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 5% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..832
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..832
                     /product="apoptotic chromatin condensation inducer in the
                     nucleus isoform X10"
                     /calculated_mol_wt=92590
     Region          72..106
                     /region_name="SAP"
                     /note="Putative DNA-binding (bihelical) motif predicted to
                     be involved in chromosomal organisation; smart00513"
                     /db_xref="CDD:128789"
     Region          <210..413
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     CDS             1..832
                     /gene="ACIN1"
                     /gene_synonym="ACINUS; ACN; fSAP152"
                     /coded_by="XM_047431118.1:329..2827"
                     /db_xref="GeneID:22985"
                     /db_xref="HGNC:HGNC:17066"
                     /db_xref="MIM:604562"
ORIGIN      
        1 mwrrkhprts ggtrgvlsgn rgveygsgrg hlgtfegrwr klpkmpeavg tdpstsrkma
       61 eleevtldgk plqalrvtdl kaaleqrgla ksgqksalvk rlkgalmlen lqkhstphaa
      121 fqpnsqigee msqnsfikqy lekqqellrq rlereareaa eleeasaese demihpegva
      181 sllppdfqss lerpelelsr hsprksssis eekgdsddek prkgerrssr vrqaraakls
      241 egsqpaeeee dqetpsrnlr vradrnlkte eeeeeeeeee eddeeeegdd egqksreapi
      301 lkefkeegee iprvkpeemm derpktrsqe qevlerggrf trsqeearks hlarqqqeke
      361 mkttspleee ereikssqgl kekskspspp rltedrkkas lvalpeqtas eeetpppllt
      421 keassppphp qlhseeeiep megpapavli qlsppntdad trellvsqht vqlvgglspl
      481 sspsdtkaes paekvpeesv lplvqkstla dysaqkdlep esdrsaqplp lkieelalak
      541 giteeclkqp sleqkegrra shtllpshrl kqsadssssr sssssssssr srsrspdssg
      601 srshsplrsk qrdvaqarth anprgrpkmg srstsesrsr srsrsrsass nsrkslspgv
      661 srdsstsyte tkdpssgqev atppvpqlqv cepkertsts sssvqarrls qpesaekhvt
      721 qrlqpergsp kkceaeeaep paatqpqtse tqtshlpese rihhtveeke evtmdtsenr
      781 pendvpeppm piadqvsndd rpegsvedee kkeylmygnp pvkynpaqla nr
//
LOCUS       XP_047287075             804 aa            linear   PRI 05-AUG-2025
DEFINITION  apoptotic chromatin condensation inducer in the nucleus isoform X11
            [Homo sapiens].
ACCESSION   XP_047287075
VERSION     XP_047287075.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431119.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 5% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..804
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..804
                     /product="apoptotic chromatin condensation inducer in the
                     nucleus isoform X11"
                     /calculated_mol_wt=89265
     Region          72..106
                     /region_name="SAP"
                     /note="Putative DNA-binding (bihelical) motif predicted to
                     be involved in chromosomal organisation; smart00513"
                     /db_xref="CDD:128789"
     Region          <141..373
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     CDS             1..804
                     /gene="ACIN1"
                     /gene_synonym="ACINUS; ACN; fSAP152"
                     /coded_by="XM_047431119.1:329..2743"
                     /db_xref="GeneID:22985"
                     /db_xref="HGNC:HGNC:17066"
                     /db_xref="MIM:604562"
ORIGIN      
        1 mwrrkhprts ggtrgvlsgn rgveygsgrg hlgtfegrwr klpkmpeavg tdpstsrkma
       61 eleevtldgk plqalrvtdl kaaleqrgla ksgqksalvk rlkgalmlen lqkhstphaa
      121 fqpnsqigee msqnsfikqy lekqqellrq rlereareaa elegksssis eekgdsddek
      181 prkgerrssr vrqaraakls egsqpaeeee dqetpsrnlr vradrnlkte eeeeeeeeee
      241 eddeeeegdd egqksreapi lkefkeegee iprvkpeemm derpktrsqe qevlerggrf
      301 trsqeearks hlarqqqeke mkttspleee ereikssqgl kekskspspp rltedrkkas
      361 lvalpeqtas eeetpppllt keassppphp qlhseeeiep megpapavli qlsppntdad
      421 trellvsqht vqlvgglspl sspsdtkaes paekvpeesv lplvqkstla dysaqkdlep
      481 esdrsaqplp lkieelalak giteeclkqp sleqkegrra shtllpshrl kqsadssssr
      541 sssssssssr srsrspdssg srshsplrsk qrdvaqarth anprgrpkmg srstsesrsr
      601 srsrsrsass nsrkslspgv srdsstsyte tkdpssgqev atppvpqlqv cepkertsts
      661 sssvqarrls qpesaekhvt qrlqpergsp kkceaeeaep paatqpqtse tqtshlpese
      721 rihhtveeke evtmdtsenr pendvpeppm piadqvsndd rpegsvedee kkevniqaty
      781 wggwagmdlg ervehssdps ytvg
//
LOCUS       XP_024305280             802 aa            linear   PRI 05-AUG-2025
DEFINITION  apoptotic chromatin condensation inducer in the nucleus isoform X12
            [Homo sapiens].
ACCESSION   XP_024305280
VERSION     XP_024305280.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449512.2
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 5% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..802
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..802
                     /product="apoptotic chromatin condensation inducer in the
                     nucleus isoform X12"
                     /calculated_mol_wt=89228
     Region          72..106
                     /region_name="SAP"
                     /note="Putative DNA-binding (bihelical) motif predicted to
                     be involved in chromosomal organisation; smart00513"
                     /db_xref="CDD:128789"
     Region          <141..373
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     CDS             1..802
                     /gene="ACIN1"
                     /gene_synonym="ACINUS; ACN; fSAP152"
                     /coded_by="XM_024449512.2:329..2737"
                     /db_xref="GeneID:22985"
                     /db_xref="HGNC:HGNC:17066"
                     /db_xref="MIM:604562"
ORIGIN      
        1 mwrrkhprts ggtrgvlsgn rgveygsgrg hlgtfegrwr klpkmpeavg tdpstsrkma
       61 eleevtldgk plqalrvtdl kaaleqrgla ksgqksalvk rlkgalmlen lqkhstphaa
      121 fqpnsqigee msqnsfikqy lekqqellrq rlereareaa elegksssis eekgdsddek
      181 prkgerrssr vrqaraakls egsqpaeeee dqetpsrnlr vradrnlkte eeeeeeeeee
      241 eddeeeegdd egqksreapi lkefkeegee iprvkpeemm derpktrsqe qevlerggrf
      301 trsqeearks hlarqqqeke mkttspleee ereikssqgl kekskspspp rltedrkkas
      361 lvalpeqtas eeetpppllt keassppphp qlhseeeiep megpapavli qlsppntdad
      421 trellvsqht vqlvgglspl sspsdtkaes paekvpeesv lplvqkstla dysaqkdlep
      481 esdrsaqplp lkieelalak giteeclkqp sleqkegrra shtllpshrl kqsadssssr
      541 sssssssssr srsrspdssg srshsplrsk qrdvaqarth anprgrpkmg srstsesrsr
      601 srsrsrsass nsrkslspgv srdsstsyte tkdpssgqev atppvpqlqv cepkertsts
      661 sssvqarrls qpesaekhvt qrlqpergsp kkceaeeaep paatqpqtse tqtshlpese
      721 rihhtveeke evtmdtsenr pendvpeppm piadqvsndd rpegsvedee kkevllprkt
      781 lskylmygnp pvkynpaqla nr
//
LOCUS       XP_047287076             792 aa            linear   PRI 05-AUG-2025
DEFINITION  apoptotic chromatin condensation inducer in the nucleus isoform X13
            [Homo sapiens].
ACCESSION   XP_047287076
VERSION     XP_047287076.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431120.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 6% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..792
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..792
                     /product="apoptotic chromatin condensation inducer in the
                     nucleus isoform X13"
                     /calculated_mol_wt=88091
     Region          72..106
                     /region_name="SAP"
                     /note="Putative DNA-binding (bihelical) motif predicted to
                     be involved in chromosomal organisation; smart00513"
                     /db_xref="CDD:128789"
     Region          <141..373
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     CDS             1..792
                     /gene="ACIN1"
                     /gene_synonym="ACINUS; ACN; fSAP152"
                     /coded_by="XM_047431120.1:329..2707"
                     /db_xref="GeneID:22985"
                     /db_xref="HGNC:HGNC:17066"
                     /db_xref="MIM:604562"
ORIGIN      
        1 mwrrkhprts ggtrgvlsgn rgveygsgrg hlgtfegrwr klpkmpeavg tdpstsrkma
       61 eleevtldgk plqalrvtdl kaaleqrgla ksgqksalvk rlkgalmlen lqkhstphaa
      121 fqpnsqigee msqnsfikqy lekqqellrq rlereareaa elegksssis eekgdsddek
      181 prkgerrssr vrqaraakls egsqpaeeee dqetpsrnlr vradrnlkte eeeeeeeeee
      241 eddeeeegdd egqksreapi lkefkeegee iprvkpeemm derpktrsqe qevlerggrf
      301 trsqeearks hlarqqqeke mkttspleee ereikssqgl kekskspspp rltedrkkas
      361 lvalpeqtas eeetpppllt keassppphp qlhseeeiep megpapavli qlsppntdad
      421 trellvsqht vqlvgglspl sspsdtkaes paekvpeesv lplvqkstla dysaqkdlep
      481 esdrsaqplp lkieelalak giteeclkqp sleqkegrra shtllpshrl kqsadssssr
      541 sssssssssr srsrspdssg srshsplrsk qrdvaqarth anprgrpkmg srstsesrsr
      601 srsrsrsass nsrkslspgv srdsstsyte tkdpssgqev atppvpqlqv cepkertsts
      661 sssvqarrls qpesaekhvt qrlqpergsp kkceaeeaep paatqpqtse tqtshlpese
      721 rihhtveeke evtmdtsenr pendvpeppm piadqvsndd rpegsvedee kkeylmygnp
      781 pvkynpaqla nr
//
LOCUS       XP_005267475             583 aa            linear   PRI 05-AUG-2025
DEFINITION  apoptotic chromatin condensation inducer in the nucleus isoform X14
            [Homo sapiens].
ACCESSION   XP_005267475
VERSION     XP_005267475.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267418.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..583
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..583
                     /product="apoptotic chromatin condensation inducer in the
                     nucleus isoform X14"
                     /calculated_mol_wt=67435
     Region          253..339
                     /region_name="RRM_ACINU"
                     /note="RNA recognition motif (RRM) found in apoptotic
                     chromatin condensation inducer in the nucleus (acinus) and
                     similar proteins; cd12432"
                     /db_xref="CDD:409866"
     Region          <448..478
                     /region_name="RSB_motif"
                     /note="RNSP1-SAP18 binding (RSB) motif; pfam16294"
                     /db_xref="CDD:465085"
     CDS             1..583
                     /gene="ACIN1"
                     /gene_synonym="ACINUS; ACN; fSAP152"
                     /coded_by="XM_005267418.2:423..2174"
                     /db_xref="GeneID:22985"
                     /db_xref="HGNC:HGNC:17066"
                     /db_xref="MIM:604562"
ORIGIN      
        1 mlseskegee keevtmdtse nrpendvpep pmpiadqvsn ddrpegsved eekkesslpk
       61 sfkrkisvvs atkgvpagns dteggqpgrk rrwgastatt qkkpsisitt eslkslipdi
      121 kplagqeavv dlhaddsris edeterngdd gthdkglkic rtvtqvvpae gqengqreee
      181 eeekepeaep pvppqvsvev alpppaehev kkvtlgdtlt rrsisqqksg vsitiddpvr
      241 taqvpspprg kisnivhisn lvrpftlgql kellgrtgtl veeafwidki kshcfvtyst
      301 veeavatrta lhgvkwpqsn pkflcadyae qdeldyhrgl lvdrpsetkt eeqgiprplh
      361 ppppppvqpp qhpraeqreq eravreqwae reremerrer trserewdrd kvregprsrs
      421 rsrdrrrker akskekksek kekaqeeppa kllddlfrkt kaapciywlp ltdsqivqke
      481 aeraeraker ekrrkeqeee eqkerekeae rernrqlere krrehsrerd rererererd
      541 rgdrdrdrer drergrerdr rdtkrhsrsr srstpvrdrg grr
//
LOCUS       XP_005267477            2349 aa            linear   PRI 05-AUG-2025
DEFINITION  pecanex-like protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_005267477
VERSION     XP_005267477.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267420.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2349
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2349
                     /product="pecanex-like protein 1 isoform X1"
                     /calculated_mol_wt=259448
     Region          1790..2016
                     /region_name="Pecanex_C"
                     /note="Pecanex protein (C-terminus); pfam05041"
                     /db_xref="CDD:461533"
     CDS             1..2349
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /coded_by="XM_005267420.5:393..7442"
                     /db_xref="GeneID:22990"
                     /db_xref="HGNC:HGNC:19740"
                     /db_xref="MIM:617655"
ORIGIN      
        1 mgsqtlqilr qgvwaalsgg wyydphqatf vnalhlylwl fllglpftly malpstmiiv
       61 avycpviaav fivlkmvnyr lhraldagev vdrtaneftd qrtkaeqgnc strrkdsngp
      121 sdpgggiems efireatppv gcssrnsyag ldpsnqigsg ssrlgtaati kgdtdtakts
      181 ddislslgqs sslckegsee qdlaadrklf rlvsndsfis iqpslsscgq dlprdfsdkv
      241 nlpshnhhhh vdqslssacd tevaslvplh shsyrkdhrp rgvprtsssa vafpdtslnd
      301 fplyqqrrgl dpvselessk plsgskeslv ensglsgefq lagdlkints qpptksgksk
      361 plkaeksmds lrslstrssg stesycsgtd rdtnstvssy kseqtssthi esilsehees
      421 pkagtksgrk keccagpeek nscasdkrts sekiameast nsgvheakdp tpsdemhnqr
      481 glstsaseea nknphaneft sqgdrppgnt aenkeeksdk savsvdskvr kdvggkqkeg
      541 dvrpksssvi hrtasahksg rrrtgkkras sfdssrhrdy vcfrgvsgtk phsaifchde
      601 dssdqsdlsr assvqsahqf ssdsssstts hscqspegry salktkhthk ergtdsehth
      661 kahlvpegts kkratrrtss tnsaktrarv lsldsgtvac lndsnrlmap esikplttsk
      721 sdleakegev ldelsllgra sqletvtrsr nslpnqvafp egeeqdavsg aaqaseeavs
      781 frrerstfrr qavrrrhnag snptpptlli gsplslqdgq qgqqstaqvk vqsrppsqaa
      841 vlsasasllv rngsvhleas hdnasavggs slhdelgkfs stlyetggcd mslvnfepaa
      901 rrasnicdtd shvssstsvr fyphdvlslp qirlnrllti dtdlleqqdi dlspdlaaty
      961 gpteeaaqkv khyyrfwilp qlwiginfdr ltllalfdrn reilenvlav ilailvaflg
     1021 silliqgffr diwvfqfclv iascqysllk svqpdssspr hghnriiays rpvyfciccg
     1081 liwlldygsr nltatkfkly gitftnplvf isardlvivf tlcfpivffi gllpqvntfv
     1141 mylceqldih ifggnattsl laalysfics ivavallygl cygalkdswd gqhipvlfsi
     1201 fcgllvavsy hlsrqssdps vlfslvqski fpkteeknpe dplsevkdpl peklrnsvse
     1261 rlqsdlvvci vigvlyfaih vstvftvlqp alkyvlytlv gfvgfvthyv lpqvrkqlpw
     1321 hcfshpllkt leynqyevri liytalldaa tmmwfeklhv wllfveknii yplivlnels
     1381 ssaetiaspk klntelgalm itvaglkllr ssfssptyqy vtviftvlff kfdyeafset
     1441 mlldlffmsi lfnklwelly klqfvytyia pwqitwgsaf hafaqpfavp hsamlfiqaa
     1501 vsaffstpln pflgsaifit syvrpvkfwe rdyntkrvdh sntrlasqld rnpgsddnnl
     1561 nsifyehltr slqhslcgdl llgrwgnyst gdcfilasdy lnalvhliei gnglvtfqlr
     1621 glefrgtycq qreveaiteg veedegfccc epghiphmls fnaafsqrwl awevivtkyi
     1681 legysitdns aasmlqvfdl rkvlttyyvk giiyyvttss kleewlanet mqeglrlcad
     1741 rnyvdvdptf npnidedydh rlagisresf cviylnwiey cssrrakpvd vdkdsslvtl
     1801 cyglcvlgrr algtashhms snlesflygl halfkgdfri ssirdewifa dmellrkvvv
     1861 pgirmsiklh qdhftspdey ddptvlyeai vsheknlvia hegdpawrsa vlanspslla
     1921 lrhvmddgtn eykiimlnrr ylsfrvikvn kecvrglwag qqqelvflrn rnpergsiqn
     1981 akqalrnmin sscdqpigyp ifvsplttsy sdsheqlkdi lggpislgni rnfivstwhr
     2041 lrkgcgagcn sggniedsdt gggtsctgnn attannphsn vtqgsignpg qgsgtglhpp
     2101 vtsypptlgt shsshsvqsg lvrqsparas vasqssycys srhsslrmst tgfvpcrrss
     2161 tsqislrnlp ssiqsrlsmv nqmepsgqsg lacvqhglps sssssqsipa ckhhtlvgfl
     2221 ateggqssat daqpgntlsp annshsrkae viyrvqivdp sqileginls krkelqwpde
     2281 girlkagrns wkdwspqegm eghvihrwvp csrdpgtrsh idkavllvqi ddkyvtviet
     2341 gvlelgaev
//
LOCUS       XP_005267478            2348 aa            linear   PRI 05-AUG-2025
DEFINITION  pecanex-like protein 1 isoform X2 [Homo sapiens].
ACCESSION   XP_005267478
VERSION     XP_005267478.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267421.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2348
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2348
                     /product="pecanex-like protein 1 isoform X2"
                     /calculated_mol_wt=259377
     Region          1789..2015
                     /region_name="Pecanex_C"
                     /note="Pecanex protein (C-terminus); pfam05041"
                     /db_xref="CDD:461533"
     CDS             1..2348
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /coded_by="XM_005267421.5:393..7439"
                     /db_xref="GeneID:22990"
                     /db_xref="HGNC:HGNC:19740"
                     /db_xref="MIM:617655"
ORIGIN      
        1 mgsqtlqilr qgvwaalsgg wyydphqatf vnalhlylwl fllglpftly malpstmiiv
       61 avycpviaav fivlkmvnyr lhraldagev vdrtaneftd qrtkaeqgnc strrkdsngp
      121 sdpgggiems efireatppv gcssrnsyag ldpsnqigsg ssrlgtaati kgdtdtakts
      181 ddislslgqs sslckegsee qdlaadrklf rlvsndsfis iqpslsscgq dlprdfsdkv
      241 nlpshnhhhh vdqslssacd tevaslvplh shsyrkdhrp rgvprtsssa vafpdtslnd
      301 fplyqqrrgl dpvselessk plsgskeslv ensglsgefq lagdlkints qpptksgksk
      361 plkaeksmds lrslstrssg stesycsgtd rdtnstvssy kseqtssthi esilsehees
      421 pkagtksgrk keccagpeek nscasdkrts sekiameast nsgvheakdp tpsdemhnqr
      481 glstsaseea nknphaneft sqgdrppgnt aenkeeksdk savsvdskvr kdvggkqkeg
      541 dvrpksssvi hrtasahksg rrrtgkkras sfdssrhrdy vcfrgvsgtk phsaifchde
      601 dssdqsdlsr assvqsahqf ssdsssstts hscqspegry salktkhthk ergtdsehth
      661 kahlvpegts kkratrrtss tnsaktrarv lsldsgtvac lndsnrlmap esikplttsk
      721 sdleakegev ldelsllgra sqletvtrsr nslpnqvafp egeeqdavsg aqaseeavsf
      781 rrerstfrrq avrrrhnags nptpptllig splslqdgqq gqqstaqvkv qsrppsqaav
      841 lsasasllvr ngsvhleash dnasavggss lhdelgkfss tlyetggcdm slvnfepaar
      901 rasnicdtds hvssstsvrf yphdvlslpq irlnrlltid tdlleqqdid lspdlaatyg
      961 pteeaaqkvk hyyrfwilpq lwiginfdrl tllalfdrnr eilenvlavi lailvaflgs
     1021 illiqgffrd iwvfqfclvi ascqysllks vqpdsssprh ghnriiaysr pvyfciccgl
     1081 iwlldygsrn ltatkfklyg itftnplvfi sardlvivft lcfpivffig llpqvntfvm
     1141 ylceqldihi fggnattsll aalysficsi vavallyglc ygalkdswdg qhipvlfsif
     1201 cgllvavsyh lsrqssdpsv lfslvqskif pkteeknped plsevkdplp eklrnsvser
     1261 lqsdlvvciv igvlyfaihv stvftvlqpa lkyvlytlvg fvgfvthyvl pqvrkqlpwh
     1321 cfshpllktl eynqyevril iytalldaat mmwfeklhvw llfvekniiy plivlnelss
     1381 saetiaspkk lntelgalmi tvaglkllrs sfssptyqyv tviftvlffk fdyeafsetm
     1441 lldlffmsil fnklwellyk lqfvytyiap wqitwgsafh afaqpfavph samlfiqaav
     1501 saffstplnp flgsaifits yvrpvkfwer dyntkrvdhs ntrlasqldr npgsddnnln
     1561 sifyehltrs lqhslcgdll lgrwgnystg dcfilasdyl nalvhlieig nglvtfqlrg
     1621 lefrgtycqq reveaitegv eedegfccce pghiphmlsf naafsqrwla wevivtkyil
     1681 egysitdnsa asmlqvfdlr kvlttyyvkg iiyyvttssk leewlanetm qeglrlcadr
     1741 nyvdvdptfn pnidedydhr lagisresfc viylnwieyc ssrrakpvdv dkdsslvtlc
     1801 yglcvlgrra lgtashhmss nlesflyglh alfkgdfris sirdewifad mellrkvvvp
     1861 girmsiklhq dhftspdeyd dptvlyeaiv sheknlviah egdpawrsav lanspsllal
     1921 rhvmddgtne ykiimlnrry lsfrvikvnk ecvrglwagq qqelvflrnr npergsiqna
     1981 kqalrnmins scdqpigypi fvsplttsys dsheqlkdil ggpislgnir nfivstwhrl
     2041 rkgcgagcns ggniedsdtg ggtsctgnna ttannphsnv tqgsignpgq gsgtglhppv
     2101 tsypptlgts hsshsvqsgl vrqsparasv asqssycyss rhsslrmstt gfvpcrrsst
     2161 sqislrnlps siqsrlsmvn qmepsgqsgl acvqhglpss ssssqsipac khhtlvgfla
     2221 teggqssatd aqpgntlspa nnshsrkaev iyrvqivdps qileginlsk rkelqwpdeg
     2281 irlkagrnsw kdwspqegme ghvihrwvpc srdpgtrshi dkavllvqid dkyvtvietg
     2341 vlelgaev
//
LOCUS       XP_005267479            2344 aa            linear   PRI 05-AUG-2025
DEFINITION  pecanex-like protein 1 isoform X3 [Homo sapiens].
ACCESSION   XP_005267479
VERSION     XP_005267479.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267422.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2344
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2344
                     /product="pecanex-like protein 1 isoform X3"
                     /calculated_mol_wt=258909
     Region          1785..2011
                     /region_name="Pecanex_C"
                     /note="Pecanex protein (C-terminus); pfam05041"
                     /db_xref="CDD:461533"
     CDS             1..2344
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /coded_by="XM_005267422.5:393..7427"
                     /db_xref="GeneID:22990"
                     /db_xref="HGNC:HGNC:19740"
                     /db_xref="MIM:617655"
ORIGIN      
        1 mgsqtlqilr qgvwaalsgg wyydphqatf vnalhlylwl fllglpftly malpstmiiv
       61 avycpviaav fivlkmvnyr lhraldagev vdrtaneftd qrtkaeqgnc strrkdsngp
      121 sdpgggiems efireatppv gcssrnsyag ldpsnqigsg ssrlgtaati kgdtdtakts
      181 ddislslgqs sslckegsee qdlaadrklf rlvsndsfis iqpslsscgq dlprdfsdkv
      241 nlpshnhhhh vdqslssacd tevaslvplh shsyrkdhrp rgvprtsssa vafpdtslnd
      301 fplyqqrrgl dpvselessk plsgskeslv ensglsgefq lagdlkints qpptksgksk
      361 plkaeksmds lrslstrssg stesycsgtd rdtnstvssy kseqtssthi esilsehees
      421 pkagtksgrk keccagpeek nscasdkrts sekiameast nsgvheakdp tpsdemhnqr
      481 glstsaseea nknphaneft sqgdrppgnt aenkeeksdk savsvdskvr kdvggkqkeg
      541 dvrpksssvi hrtasahksg rrrtgkkras sfdssrhrdy vcfrgvsgtk phsaifchde
      601 dssdqsdlsr assvqsahqf ssdsssstts hscqspegry salktkhthk ergtdsehth
      661 kahlvpegts kkratrrtss tnsaktrarv lsldsgtvac lndsnrlmap esikplttsk
      721 sdleakegev ldelsllgra sqletvtrsr nslpnqvafp egeeqdavsg aaqaseeavs
      781 frrerstfrr qavrrrhnag snptpptlli gsplslqdgq qgqqstaqvk vqsrppsqaa
      841 vlsasasllv rngsvhleas hdnasavggs slhdelgkfs stlyetggcd mslvnfepaa
      901 rrasnicdtd shvssstsvr fyphdvirln rlltidtdll eqqdidlspd laatygptee
      961 aaqkvkhyyr fwilpqlwig infdrltlla lfdrnreile nvlavilail vaflgsilli
     1021 qgffrdiwvf qfclviascq ysllksvqpd sssprhghnr iiaysrpvyf ciccgliwll
     1081 dygsrnltat kfklygitft nplvfisard lvivftlcfp ivffigllpq vntfvmylce
     1141 qldihifggn attsllaaly sficsivava llyglcygal kdswdgqhip vlfsifcgll
     1201 vavsyhlsrq ssdpsvlfsl vqskifpkte eknpedplse vkdplpeklr nsvserlqsd
     1261 lvvcivigvl yfaihvstvf tvlqpalkyv lytlvgfvgf vthyvlpqvr kqlpwhcfsh
     1321 pllktleynq yevriliyta lldaatmmwf eklhvwllfv ekniiypliv lnelsssaet
     1381 iaspkklnte lgalmitvag lkllrssfss ptyqyvtvif tvlffkfdye afsetmlldl
     1441 ffmsilfnkl wellyklqfv ytyiapwqit wgsafhafaq pfavphsaml fiqaavsaff
     1501 stplnpflgs aifitsyvrp vkfwerdynt krvdhsntrl asqldrnpgs ddnnlnsify
     1561 ehltrslqhs lcgdlllgrw gnystgdcfi lasdylnalv hlieignglv tfqlrglefr
     1621 gtycqqreve aitegveede gfcccepghi phmlsfnaaf sqrwlawevi vtkyilegys
     1681 itdnsaasml qvfdlrkvlt tyyvkgiiyy vttsskleew lanetmqegl rlcadrnyvd
     1741 vdptfnpnid edydhrlagi sresfcviyl nwieycssrr akpvdvdkds slvtlcyglc
     1801 vlgrralgta shhmssnles flyglhalfk gdfrissird ewifadmell rkvvvpgirm
     1861 siklhqdhft spdeyddptv lyeaivshek nlviahegdp awrsavlans psllalrhvm
     1921 ddgtneykii mlnrrylsfr vikvnkecvr glwagqqqel vflrnrnper gsiqnakqal
     1981 rnminsscdq pigypifvsp lttsysdshe qlkdilggpi slgnirnfiv stwhrlrkgc
     2041 gagcnsggni edsdtgggts ctgnnattan nphsnvtqgs ignpgqgsgt glhppvtsyp
     2101 ptlgtshssh svqsglvrqs parasvasqs sycyssrhss lrmsttgfvp crrsstsqis
     2161 lrnlpssiqs rlsmvnqmep sgqsglacvq hglpssssss qsipackhht lvgflategg
     2221 qssatdaqpg ntlspannsh srkaeviyrv qivdpsqile ginlskrkel qwpdegirlk
     2281 agrnswkdws pqegmeghvi hrwvpcsrdp gtrshidkav llvqiddkyv tvietgvlel
     2341 gaev
//
LOCUS       XP_047287077            2340 aa            linear   PRI 05-AUG-2025
DEFINITION  pecanex-like protein 1 isoform X4 [Homo sapiens].
ACCESSION   XP_047287077
VERSION     XP_047287077.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431121.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2340
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2340
                     /product="pecanex-like protein 1 isoform X4"
                     /calculated_mol_wt=258475
     Region          1781..2007
                     /region_name="Pecanex_C"
                     /note="Pecanex protein (C-terminus); pfam05041"
                     /db_xref="CDD:461533"
     CDS             1..2340
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /coded_by="XM_047431121.1:393..7415"
                     /db_xref="GeneID:22990"
                     /db_xref="HGNC:HGNC:19740"
                     /db_xref="MIM:617655"
ORIGIN      
        1 mgsqtlqilr qgvwaalsgg wyydphqatf vnalhlylwl fllglpftly malpstmiiv
       61 avycpviaav fivlkmvnyr lhraldagev vdrtaneftd qrtkaeqgnc strrkdsngp
      121 sdpgggiems efireatppv gcssrnsyag ldpsnqigsg ssrlgtaati kgdtdtakts
      181 ddislslgqs sslckegsee qdlaadrklf rlvsndsfis iqpslsscgq dlprdfsdkv
      241 nlpshnhhhh vdqslssacd tevaslvplh shsyrkdhrp rgvprtsssa vafpdtslnd
      301 fplyqqrrgl dpvselessk plsgskeslv ensglsgefq lagdlkints qpptksgksk
      361 plkaeksmds lrslstrssg stesycsgtd rdtnstvssy kseqtssthi esilsehees
      421 pkagtksgrk keccagpeek nscasdkrts sekiameast nsgvheakdp tpsdemhnqr
      481 glstsaseea nknphaneft sqgdrppgnt aenkeeksdk savsvdskvr kdvggkqkeg
      541 dvrpksssvi hrtasahksg rrrtgkkras sfdssrhrdy vcfrgvsgtk phsaifchde
      601 dssdqsdlsr assvqsahqf ssdsssstts hscqspegry salktkhthk ergtdsehth
      661 kahlvpegts kkratrrtss tnsaktrarv lsldsgtvac lndsnrlmap esikplttsk
      721 sdleakegev ldelsllgra sqletvtrsr nslpnqvafp egeeqdavsg aqaseeavsf
      781 rrerstfrrq avrrrhnags nptpptllig splslqdgqq gqqstaqvkv qsrppsqaav
      841 lsasasllvr ngsvhleash dnasavggss lhdelgkfss tlyetggcdm slvnfepaar
      901 rasnicdtds hvssstsvrf yphdvlslpq irlnrlltid tdlleqqdid lspdlaatyg
      961 pteeaaqkvk hyyrfwilpq lwiginfdrl tllalfdrnr eilenvlavi lailvaflgs
     1021 illiqgffrd iwvfqfclvi ascqysllks vqpdsssprh ghnriiaysr pvyfciccgl
     1081 iwlldygsrn ltatkfklyg itftnplvfi sardlvivft lcfpivffig llpqvntfvm
     1141 ylceqldihi fggnattsll aalysficsi vavallyglc ygalkdswdg qhipvlfsif
     1201 cgllvavsyh lsrqssdpsv lfslvqskif pkteeknped plsevkdplp eklrnsvser
     1261 lqsdlvvciv igvlyfaihv stvftvlqpa lkyvlytlvg fvgfvthyvl pqvrkqlpwh
     1321 cfshpllktl eynqyevrna atmmwfeklh vwllfvekni iyplivlnel sssaetiasp
     1381 kklntelgal mitvaglkll rssfssptyq yvtviftvlf fkfdyeafse tmlldlffms
     1441 ilfnklwell yklqfvytyi apwqitwgsa fhafaqpfav phsamlfiqa avsaffstpl
     1501 npflgsaifi tsyvrpvkfw erdyntkrvd hsntrlasql drnpgsddnn lnsifyehlt
     1561 rslqhslcgd lllgrwgnys tgdcfilasd ylnalvhlie ignglvtfql rglefrgtyc
     1621 qqreveaite gveedegfcc cepghiphml sfnaafsqrw lawevivtky ilegysitdn
     1681 saasmlqvfd lrkvlttyyv kgiiyyvtts skleewlane tmqeglrlca drnyvdvdpt
     1741 fnpnidedyd hrlagisres fcviylnwie ycssrrakpv dvdkdsslvt lcyglcvlgr
     1801 ralgtashhm ssnlesflyg lhalfkgdfr issirdewif admellrkvv vpgirmsikl
     1861 hqdhftspde yddptvlyea ivsheknlvi ahegdpawrs avlanspsll alrhvmddgt
     1921 neykiimlnr rylsfrvikv nkecvrglwa gqqqelvflr nrnpergsiq nakqalrnmi
     1981 nsscdqpigy pifvspltts ysdsheqlkd ilggpislgn irnfivstwh rlrkgcgagc
     2041 nsggniedsd tgggtsctgn nattannphs nvtqgsignp gqgsgtglhp pvtsypptlg
     2101 tshsshsvqs glvrqspara svasqssycy ssrhsslrms ttgfvpcrrs stsqislrnl
     2161 pssiqsrlsm vnqmepsgqs glacvqhglp ssssssqsip ackhhtlvgf lateggqssa
     2221 tdaqpgntls pannshsrka eviyrvqivd psqileginl skrkelqwpd egirlkagrn
     2281 swkdwspqeg meghvihrwv pcsrdpgtrs hidkavllvq iddkyvtvie tgvlelgaev
//
LOCUS       XP_005267480            2336 aa            linear   PRI 05-AUG-2025
DEFINITION  pecanex-like protein 1 isoform X5 [Homo sapiens].
ACCESSION   XP_005267480
VERSION     XP_005267480.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267423.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2336
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2336
                     /product="pecanex-like protein 1 isoform X5"
                     /calculated_mol_wt=258007
     Region          1777..2003
                     /region_name="Pecanex_C"
                     /note="Pecanex protein (C-terminus); pfam05041"
                     /db_xref="CDD:461533"
     CDS             1..2336
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /coded_by="XM_005267423.5:393..7403"
                     /db_xref="GeneID:22990"
                     /db_xref="HGNC:HGNC:19740"
                     /db_xref="MIM:617655"
ORIGIN      
        1 mgsqtlqilr qgvwaalsgg wyydphqatf vnalhlylwl fllglpftly malpstmiiv
       61 avycpviaav fivlkmvnyr lhraldagev vdrtaneftd qrtkaeqgnc strrkdsngp
      121 sdpgggiems efireatppv gcssrnsyag ldpsnqigsg ssrlgtaati kgdtdtakts
      181 ddislslgqs sslckegsee qdlaadrklf rlvsndsfis iqpslsscgq dlprdfsdkv
      241 nlpshnhhhh vdqslssacd tevaslvplh shsyrkdhrp rgvprtsssa vafpdtslnd
      301 fplyqqrrgl dpvselessk plsgskeslv ensglsgefq lagdlkints qpptksgksk
      361 plkaeksmds lrslstrssg stesycsgtd rdtnstvssy kseqtssthi esilsehees
      421 pkagtksgrk keccagpeek nscasdkrts sekiameast nsgvheakdp tpsdemhnqr
      481 glstsaseea nknphaneft sqgdrppgnt aenkeeksdk savsvdskvr kdvggkqkeg
      541 dvrpksssvi hrtasahksg rrrtgkkras sfdssrhrdy vcfrgvsgtk phsaifchde
      601 dssdqsdlsr assvqsahqf ssdsssstts hscqspegry salktkhthk ergtdsehth
      661 kahlvpegts kkratrrtss tnsaktrarv lsldsgtvac lndsnrlmap esikplttsk
      721 sdleakegev ldelsllgra sqletvtrsr nslpnqvafp egeeqdavsg aaqaseeavs
      781 frrerstfrr qavrrrhnag snptpptlli gsplslqdgq qgqqstaqvk vqsrppsqaa
      841 vlsasasllv rngsvhleas hdnasavggs slhdelgkfs stlyetggcd mslvnfepaa
      901 rrasnicdtd shvssstsvr fyphdvirln rlltidtdll eqqdidlspd laatygptee
      961 aaqkvkhyyr fwilpqlwig infdrltlla lfdrnreile nvlavilail vaflgsilli
     1021 qgffrdiwvf qfclviascq ysllksvqpd sssprhghnr iiaysrpvyf ciccgliwll
     1081 dygsrnltat kfklygitft nplvfisard lvivftlcfp ivffigllpq vntfvmylce
     1141 qldihifggn attsllaaly sficsivava llyglcygal kdswdgqhip vlfsifcgll
     1201 vavsyhlsrq ssdpsvlfsl vqskifpkte eknpedplse vkdplpeklr nsvserlqsd
     1261 lvvcivigvl yfaihvstvf tvlqpalkyv lytlvgfvgf vthyvlpqvr kqlpwhcfsh
     1321 pllktleynq yevrnaatmm wfeklhvwll fvekniiypl ivlnelsssa etiaspkkln
     1381 telgalmitv aglkllrssf ssptyqyvtv iftvlffkfd yeafsetmll dlffmsilfn
     1441 klwellyklq fvytyiapwq itwgsafhaf aqpfavphsa mlfiqaavsa ffstplnpfl
     1501 gsaifitsyv rpvkfwerdy ntkrvdhsnt rlasqldrnp gsddnnlnsi fyehltrslq
     1561 hslcgdlllg rwgnystgdc filasdylna lvhlieigng lvtfqlrgle frgtycqqre
     1621 veaitegvee degfcccepg hiphmlsfna afsqrwlawe vivtkyileg ysitdnsaas
     1681 mlqvfdlrkv lttyyvkgii yyvttsskle ewlanetmqe glrlcadrny vdvdptfnpn
     1741 idedydhrla gisresfcvi ylnwieycss rrakpvdvdk dsslvtlcyg lcvlgrralg
     1801 tashhmssnl esflyglhal fkgdfrissi rdewifadme llrkvvvpgi rmsiklhqdh
     1861 ftspdeyddp tvlyeaivsh eknlviaheg dpawrsavla nspsllalrh vmddgtneyk
     1921 iimlnrryls frvikvnkec vrglwagqqq elvflrnrnp ergsiqnakq alrnminssc
     1981 dqpigypifv splttsysds heqlkdilgg pislgnirnf ivstwhrlrk gcgagcnsgg
     2041 niedsdtggg tsctgnnatt annphsnvtq gsignpgqgs gtglhppvts ypptlgtshs
     2101 shsvqsglvr qsparasvas qssycyssrh sslrmsttgf vpcrrsstsq islrnlpssi
     2161 qsrlsmvnqm epsgqsglac vqhglpssss ssqsipackh htlvgflate ggqssatdaq
     2221 pgntlspann shsrkaeviy rvqivdpsqi leginlskrk elqwpdegir lkagrnswkd
     2281 wspqegmegh vihrwvpcsr dpgtrshidk avllvqiddk yvtvietgvl elgaev
//
LOCUS       XP_047287078            2335 aa            linear   PRI 05-AUG-2025
DEFINITION  pecanex-like protein 1 isoform X6 [Homo sapiens].
ACCESSION   XP_047287078
VERSION     XP_047287078.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431122.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2335
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2335
                     /product="pecanex-like protein 1 isoform X6"
                     /calculated_mol_wt=257936
     Region          1776..2002
                     /region_name="Pecanex_C"
                     /note="Pecanex protein (C-terminus); pfam05041"
                     /db_xref="CDD:461533"
     CDS             1..2335
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /coded_by="XM_047431122.1:393..7400"
                     /db_xref="GeneID:22990"
                     /db_xref="HGNC:HGNC:19740"
                     /db_xref="MIM:617655"
ORIGIN      
        1 mgsqtlqilr qgvwaalsgg wyydphqatf vnalhlylwl fllglpftly malpstmiiv
       61 avycpviaav fivlkmvnyr lhraldagev vdrtaneftd qrtkaeqgnc strrkdsngp
      121 sdpgggiems efireatppv gcssrnsyag ldpsnqigsg ssrlgtaati kgdtdtakts
      181 ddislslgqs sslckegsee qdlaadrklf rlvsndsfis iqpslsscgq dlprdfsdkv
      241 nlpshnhhhh vdqslssacd tevaslvplh shsyrkdhrp rgvprtsssa vafpdtslnd
      301 fplyqqrrgl dpvselessk plsgskeslv ensglsgefq lagdlkints qpptksgksk
      361 plkaeksmds lrslstrssg stesycsgtd rdtnstvssy kseqtssthi esilsehees
      421 pkagtksgrk keccagpeek nscasdkrts sekiameast nsgvheakdp tpsdemhnqr
      481 glstsaseea nknphaneft sqgdrppgnt aenkeeksdk savsvdskvr kdvggkqkeg
      541 dvrpksssvi hrtasahksg rrrtgkkras sfdssrhrdy vcfrgvsgtk phsaifchde
      601 dssdqsdlsr assvqsahqf ssdsssstts hscqspegry salktkhthk ergtdsehth
      661 kahlvpegts kkratrrtss tnsaktrarv lsldsgtvac lndsnrlmap esikplttsk
      721 sdleakegev ldelsllgra sqletvtrsr nslpnqvafp egeeqdavsg aqaseeavsf
      781 rrerstfrrq avrrrhnags nptpptllig splslqdgqq gqqstaqvkv qsrppsqaav
      841 lsasasllvr ngsvhleash dnasavggss lhdelgkfss tlyetggcdm slvnfepaar
      901 rasnicdtds hvssstsvrf yphdvirlnr lltidtdlle qqdidlspdl aatygpteea
      961 aqkvkhyyrf wilpqlwigi nfdrltllal fdrnreilen vlavilailv aflgsilliq
     1021 gffrdiwvfq fclviascqy sllksvqpds ssprhghnri iaysrpvyfc iccgliwlld
     1081 ygsrnltatk fklygitftn plvfisardl vivftlcfpi vffigllpqv ntfvmylceq
     1141 ldihifggna ttsllaalys ficsivaval lyglcygalk dswdgqhipv lfsifcgllv
     1201 avsyhlsrqs sdpsvlfslv qskifpktee knpedplsev kdplpeklrn svserlqsdl
     1261 vvcivigvly faihvstvft vlqpalkyvl ytlvgfvgfv thyvlpqvrk qlpwhcfshp
     1321 llktleynqy evrnaatmmw feklhvwllf vekniiypli vlnelsssae tiaspkklnt
     1381 elgalmitva glkllrssfs sptyqyvtvi ftvlffkfdy eafsetmlld lffmsilfnk
     1441 lwellyklqf vytyiapwqi twgsafhafa qpfavphsam lfiqaavsaf fstplnpflg
     1501 saifitsyvr pvkfwerdyn tkrvdhsntr lasqldrnpg sddnnlnsif yehltrslqh
     1561 slcgdlllgr wgnystgdcf ilasdylnal vhlieigngl vtfqlrglef rgtycqqrev
     1621 eaitegveed egfcccepgh iphmlsfnaa fsqrwlawev ivtkyilegy sitdnsaasm
     1681 lqvfdlrkvl ttyyvkgiiy yvttssklee wlanetmqeg lrlcadrnyv dvdptfnpni
     1741 dedydhrlag isresfcviy lnwieycssr rakpvdvdkd sslvtlcygl cvlgrralgt
     1801 ashhmssnle sflyglhalf kgdfrissir dewifadmel lrkvvvpgir msiklhqdhf
     1861 tspdeyddpt vlyeaivshe knlviahegd pawrsavlan spsllalrhv mddgtneyki
     1921 imlnrrylsf rvikvnkecv rglwagqqqe lvflrnrnpe rgsiqnakqa lrnminsscd
     1981 qpigypifvs plttsysdsh eqlkdilggp islgnirnfi vstwhrlrkg cgagcnsggn
     2041 iedsdtgggt sctgnnatta nnphsnvtqg signpgqgsg tglhppvtsy pptlgtshss
     2101 hsvqsglvrq sparasvasq ssycyssrhs slrmsttgfv pcrrsstsqi slrnlpssiq
     2161 srlsmvnqme psgqsglacv qhglpsssss sqsipackhh tlvgflateg gqssatdaqp
     2221 gntlspanns hsrkaeviyr vqivdpsqil eginlskrke lqwpdegirl kagrnswkdw
     2281 spqegmeghv ihrwvpcsrd pgtrshidka vllvqiddky vtvietgvle lgaev
//
LOCUS       XP_005267481            2312 aa            linear   PRI 05-AUG-2025
DEFINITION  pecanex-like protein 1 isoform X7 [Homo sapiens].
ACCESSION   XP_005267481
VERSION     XP_005267481.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267424.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Mar 12, 2015 this sequence version replaced XP_005267481.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2312
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2312
                     /product="pecanex-like protein 1 isoform X7"
                     /calculated_mol_wt=255269
     Region          1753..1979
                     /region_name="Pecanex_C"
                     /note="Pecanex protein (C-terminus); pfam05041"
                     /db_xref="CDD:461533"
     CDS             1..2312
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /coded_by="XM_005267424.4:12636..19574"
                     /db_xref="GeneID:22990"
                     /db_xref="HGNC:HGNC:19740"
                     /db_xref="MIM:617655"
ORIGIN      
        1 mgmktkyifh niiqalpstm iivavycpvi aavfivlkmv nyrlhralda gevvdrtane
       61 ftdqrtkaeq gncstrrkds ngpsdpgggi emsefireat ppvgcssrns yagldpsnqi
      121 gsgssrlgta atikgdtdta ktsddislsl gqssslckeg seeqdlaadr klfrlvsnds
      181 fisiqpslss cgqdlprdfs dkvnlpshnh hhhvdqslss acdtevaslv plhshsyrkd
      241 hrprgvprts ssavafpdts lndfplyqqr rgldpvsele sskplsgske slvensglsg
      301 efqlagdlki ntsqpptksg kskplkaeks mdslrslstr ssgstesycs gtdrdtnstv
      361 ssykseqtss thiesilseh eespkagtks grkkeccagp eeknscasdk rtssekiame
      421 astnsgvhea kdptpsdemh nqrglstsas eeanknphan eftsqgdrpp gntaenkeek
      481 sdksavsvds kvrkdvggkq kegdvrpkss svihrtasah ksgrrrtgkk rassfdssrh
      541 rdyvcfrgvs gtkphsaifc hdedssdqsd lsrassvqsa hqfssdssss ttshscqspe
      601 grysalktkh thkergtdse hthkahlvpe gtskkratrr tsstnsaktr arvlsldsgt
      661 vaclndsnrl mapesikplt tsksdleake gevldelsll grasqletvt rsrnslpnqv
      721 afpegeeqda vsgaaqasee avsfrrerst frrqavrrrh nagsnptppt lligsplslq
      781 dgqqgqqsta qvkvqsrpps qaavlsasas llvrngsvhl eashdnasav ggsslhdelg
      841 kfsstlyetg gcdmslvnfe paarrasnic dtdshvssst svrfyphdvl slpqirlnrl
      901 ltidtdlleq qdidlspdla atygpteeaa qkvkhyyrfw ilpqlwigin fdrltllalf
      961 drnreilenv lavilailva flgsilliqg ffrdiwvfqf clviascqys llksvqpdss
     1021 sprhghnrii aysrpvyfci ccgliwlldy gsrnltatkf klygitftnp lvfisardlv
     1081 ivftlcfpiv ffigllpqvn tfvmylceql dihifggnat tsllaalysf icsivavall
     1141 yglcygalkd swdgqhipvl fsifcgllva vsyhlsrqss dpsvlfslvq skifpkteek
     1201 npedplsevk dplpeklrns vserlqsdlv vcivigvlyf aihvstvftv lqpalkyvly
     1261 tlvgfvgfvt hyvlpqvrkq lpwhcfshpl lktleynqye vriliytall daatmmwfek
     1321 lhvwllfvek niiyplivln elsssaetia spkklntelg almitvaglk llrssfsspt
     1381 yqyvtviftv lffkfdyeaf setmlldlff msilfnklwe llyklqfvyt yiapwqitwg
     1441 safhafaqpf avphsamlfi qaavsaffst plnpflgsai fitsyvrpvk fwerdyntkr
     1501 vdhsntrlas qldrnpgsdd nnlnsifyeh ltrslqhslc gdlllgrwgn ystgdcfila
     1561 sdylnalvhl ieignglvtf qlrglefrgt ycqqreveai tegveedegf cccepghiph
     1621 mlsfnaafsq rwlawevivt kyilegysit dnsaasmlqv fdlrkvltty yvkgiiyyvt
     1681 tsskleewla netmqeglrl cadrnyvdvd ptfnpnided ydhrlagisr esfcviylnw
     1741 ieycssrrak pvdvdkdssl vtlcyglcvl grralgtash hmssnlesfl yglhalfkgd
     1801 frissirdew ifadmellrk vvvpgirmsi klhqdhftsp deyddptvly eaivsheknl
     1861 viahegdpaw rsavlansps llalrhvmdd gtneykiiml nrrylsfrvi kvnkecvrgl
     1921 wagqqqelvf lrnrnpergs iqnakqalrn minsscdqpi gypifvsplt tsysdsheql
     1981 kdilggpisl gnirnfivst whrlrkgcga gcnsggnied sdtgggtsct gnnattannp
     2041 hsnvtqgsig npgqgsgtgl hppvtsyppt lgtshsshsv qsglvrqspa rasvasqssy
     2101 cyssrhsslr msttgfvpcr rsstsqislr nlpssiqsrl smvnqmepsg qsglacvqhg
     2161 lpssssssqs ipackhhtlv gflateggqs satdaqpgnt lspannshsr kaeviyrvqi
     2221 vdpsqilegi nlskrkelqw pdegirlkag rnswkdwspq egmeghvihr wvpcsrdpgt
     2281 rshidkavll vqiddkyvtv ietgvlelga ev
//
LOCUS       XP_047287079            2304 aa            linear   PRI 05-AUG-2025
DEFINITION  pecanex-like protein 1 isoform X8 [Homo sapiens].
ACCESSION   XP_047287079
VERSION     XP_047287079.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431123.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2304
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2304
                     /product="pecanex-like protein 1 isoform X8"
                     /calculated_mol_wt=254367
     Region          1745..1971
                     /region_name="Pecanex_C"
                     /note="Pecanex protein (C-terminus); pfam05041"
                     /db_xref="CDD:461533"
     CDS             1..2304
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /coded_by="XM_047431123.1:12636..19550"
                     /db_xref="GeneID:22990"
                     /db_xref="HGNC:HGNC:19740"
                     /db_xref="MIM:617655"
ORIGIN      
        1 mgmktkyifh niiqalpstm iivavycpvi aavfivlkmv nyrlhralda gevvdrtane
       61 ftdqrtkaeq gncstrrkds ngpsdpgggi emsefireat ppvgcssrns yagldpsnqi
      121 gsgssrlgta atikgdtdta ktsddislsl gqssslckeg seeqdlaadr klfrlvsnds
      181 fisiqpslss cgqdlprdfs dkvnlpshnh hhhvdqslss acdtevaslv plhshsyrkd
      241 hrprgvprts ssavafpdts lndfplyqqr rgldpvsele sskplsgske slvensglsg
      301 efqlagdlki ntsqpptksg kskplkaeks mdslrslstr ssgstesycs gtdrdtnstv
      361 ssykseqtss thiesilseh eespkagtks grkkeccagp eeknscasdk rtssekiame
      421 astnsgvhea kdptpsdemh nqrglstsas eeanknphan eftsqgdrpp gntaenkeek
      481 sdksavsvds kvrkdvggkq kegdvrpkss svihrtasah ksgrrrtgkk rassfdssrh
      541 rdyvcfrgvs gtkphsaifc hdedssdqsd lsrassvqsa hqfssdssss ttshscqspe
      601 grysalktkh thkergtdse hthkahlvpe gtskkratrr tsstnsaktr arvlsldsgt
      661 vaclndsnrl mapesikplt tsksdleake gevldelsll grasqletvt rsrnslpnqv
      721 afpegeeqda vsgaaqasee avsfrrerst frrqavrrrh nagsnptppt lligsplslq
      781 dgqqgqqsta qvkvqsrpps qaavlsasas llvrngsvhl eashdnasav ggsslhdelg
      841 kfsstlyetg gcdmslvnfe paarrasnic dtdshvssst svrfyphdvl slpqirlnrl
      901 ltidtdlleq qdidlspdla atygpteeaa qkvkhyyrfw ilpqlwigin fdrltllalf
      961 drnreilenv lavilailva flgsilliqg ffrdiwvfqf clviascqys llksvqpdss
     1021 sprhghnrii aysrpvyfci ccgliwlldy gsrnltatkf klygitftnp lvfisardlv
     1081 ivftlcfpiv ffigllpqvn tfvmylceql dihifggnat tsllaalysf icsivavall
     1141 yglcygalkd swdgqhipvl fsifcgllva vsyhlsrqss dpsvlfslvq skifpkteek
     1201 npedplsevk dplpeklrns vserlqsdlv vcivigvlyf aihvstvftv lqpalkyvly
     1261 tlvgfvgfvt hyvlpqvrkq lpwhcfshpl lktleynqye vrnaatmmwf eklhvwllfv
     1321 ekniiypliv lnelsssaet iaspkklnte lgalmitvag lkllrssfss ptyqyvtvif
     1381 tvlffkfdye afsetmlldl ffmsilfnkl wellyklqfv ytyiapwqit wgsafhafaq
     1441 pfavphsaml fiqaavsaff stplnpflgs aifitsyvrp vkfwerdynt krvdhsntrl
     1501 asqldrnpgs ddnnlnsify ehltrslqhs lcgdlllgrw gnystgdcfi lasdylnalv
     1561 hlieignglv tfqlrglefr gtycqqreve aitegveede gfcccepghi phmlsfnaaf
     1621 sqrwlawevi vtkyilegys itdnsaasml qvfdlrkvlt tyyvkgiiyy vttsskleew
     1681 lanetmqegl rlcadrnyvd vdptfnpnid edydhrlagi sresfcviyl nwieycssrr
     1741 akpvdvdkds slvtlcyglc vlgrralgta shhmssnles flyglhalfk gdfrissird
     1801 ewifadmell rkvvvpgirm siklhqdhft spdeyddptv lyeaivshek nlviahegdp
     1861 awrsavlans psllalrhvm ddgtneykii mlnrrylsfr vikvnkecvr glwagqqqel
     1921 vflrnrnper gsiqnakqal rnminsscdq pigypifvsp lttsysdshe qlkdilggpi
     1981 slgnirnfiv stwhrlrkgc gagcnsggni edsdtgggts ctgnnattan nphsnvtqgs
     2041 ignpgqgsgt glhppvtsyp ptlgtshssh svqsglvrqs parasvasqs sycyssrhss
     2101 lrmsttgfvp crrsstsqis lrnlpssiqs rlsmvnqmep sgqsglacvq hglpssssss
     2161 qsipackhht lvgflategg qssatdaqpg ntlspannsh srkaeviyrv qivdpsqile
     2221 ginlskrkel qwpdegirlk agrnswkdws pqegmeghvi hrwvpcsrdp gtrshidkav
     2281 llvqiddkyv tvietgvlel gaev
//
LOCUS       XP_005267482            2243 aa            linear   PRI 05-AUG-2025
DEFINITION  pecanex-like protein 1 isoform X9 [Homo sapiens].
ACCESSION   XP_005267482
VERSION     XP_005267482.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267425.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2243
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2243
                     /product="pecanex-like protein 1 isoform X9"
                     /calculated_mol_wt=248287
     Region          1684..1910
                     /region_name="Pecanex_C"
                     /note="Pecanex protein (C-terminus); pfam05041"
                     /db_xref="CDD:461533"
     CDS             1..2243
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /coded_by="XM_005267425.5:393..7124"
                     /db_xref="GeneID:22990"
                     /db_xref="HGNC:HGNC:19740"
                     /db_xref="MIM:617655"
ORIGIN      
        1 mgsqtlqilr qgvwaalsgg wyydphqatf vnalhlylwl fllglpftly malpstmiiv
       61 avycpviaav fivlkmvnyr lhraldagev vdrtaneftd qrtkaeqgnc strrkdsngp
      121 sdpgggiems efireatppv gcssrnsyag ldpsnqigsg ssrlgtaati kgdtdtakts
      181 ddislslgqs sslckegsee qdlaadrklf rlvsndsfis iqpslsscgq dlprdfsdkv
      241 nlpshnhhhh vdqslssacd tevaslvplh shsyrkdhrp rgvprtsssa vafpdtslnd
      301 fplyqqrrgl dpvselessk plsgskeslv ensglsgefq lagdlkints qpptksgksk
      361 plkaeksmds lrslstrssg stesycsgtd rdtnstvssy kseqtssthi esilsehees
      421 pkagtksgrk keccagpeek nscasdkrts sekiameast nsgvheakdp tpsdemhnqr
      481 glstsaseea nknphaneft sqgdrppgnt aenkeeksdk savsvdskvr kdvggkqkeg
      541 dvrpksssvi hrtasahksg rrrtgkkras sfdssrhrdy vcfrgvsgtk phsaifchde
      601 dssdqsdlsr assvqsahqf ssdsssstts hscqspegry salktkhthk ergtdsehth
      661 kahlvpegts kkratrrtss tnsaktrarv lsldsgtvac lndsnrlmap esikplttsk
      721 sdleakegev ldelsllgra sqletvtrsr nslpnqvafp egeeqdavsg gkfsstlyet
      781 ggcdmslvnf epaarrasni cdtdshvsss tsvrfyphdv lslpqirlnr lltidtdlle
      841 qqdidlspdl aatygpteea aqkvkhyyrf wilpqlwigi nfdrltllal fdrnreilen
      901 vlavilailv aflgsilliq gffrdiwvfq fclviascqy sllksvqpds ssprhghnri
      961 iaysrpvyfc iccgliwlld ygsrnltatk fklygitftn plvfisardl vivftlcfpi
     1021 vffigllpqv ntfvmylceq ldihifggna ttsllaalys ficsivaval lyglcygalk
     1081 dswdgqhipv lfsifcgllv avsyhlsrqs sdpsvlfslv qskifpktee knpedplsev
     1141 kdplpeklrn svserlqsdl vvcivigvly faihvstvft vlqpalkyvl ytlvgfvgfv
     1201 thyvlpqvrk qlpwhcfshp llktleynqy evriliytal ldaatmmwfe klhvwllfve
     1261 kniiyplivl nelsssaeti aspkklntel galmitvagl kllrssfssp tyqyvtvift
     1321 vlffkfdyea fsetmlldlf fmsilfnklw ellyklqfvy tyiapwqitw gsafhafaqp
     1381 favphsamlf iqaavsaffs tplnpflgsa ifitsyvrpv kfwerdyntk rvdhsntrla
     1441 sqldrnpgsd dnnlnsifye hltrslqhsl cgdlllgrwg nystgdcfil asdylnalvh
     1501 lieignglvt fqlrglefrg tycqqrevea itegveedeg fcccepghip hmlsfnaafs
     1561 qrwlaweviv tkyilegysi tdnsaasmlq vfdlrkvltt yyvkgiiyyv ttsskleewl
     1621 anetmqeglr lcadrnyvdv dptfnpnide dydhrlagis resfcviyln wieycssrra
     1681 kpvdvdkdss lvtlcyglcv lgrralgtas hhmssnlesf lyglhalfkg dfrissirde
     1741 wifadmellr kvvvpgirms iklhqdhfts pdeyddptvl yeaivshekn lviahegdpa
     1801 wrsavlansp sllalrhvmd dgtneykiim lnrrylsfrv ikvnkecvrg lwagqqqelv
     1861 flrnrnperg siqnakqalr nminsscdqp igypifvspl ttsysdsheq lkdilggpis
     1921 lgnirnfivs twhrlrkgcg agcnsggnie dsdtgggtsc tgnnattann phsnvtqgsi
     1981 gnpgqgsgtg lhppvtsypp tlgtshsshs vqsglvrqsp arasvasqss ycyssrhssl
     2041 rmsttgfvpc rrsstsqisl rnlpssiqsr lsmvnqmeps gqsglacvqh glpssssssq
     2101 sipackhhtl vgflateggq ssatdaqpgn tlspannshs rkaeviyrvq ivdpsqileg
     2161 inlskrkelq wpdegirlka grnswkdwsp qegmeghvih rwvpcsrdpg trshidkavl
     2221 lvqiddkyvt vietgvlelg aev
//
LOCUS       XP_047287080            2238 aa            linear   PRI 05-AUG-2025
DEFINITION  pecanex-like protein 1 isoform X10 [Homo sapiens].
ACCESSION   XP_047287080
VERSION     XP_047287080.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431124.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2238
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2238
                     /product="pecanex-like protein 1 isoform X10"
                     /calculated_mol_wt=247748
     Region          1679..1905
                     /region_name="Pecanex_C"
                     /note="Pecanex protein (C-terminus); pfam05041"
                     /db_xref="CDD:461533"
     CDS             1..2238
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /coded_by="XM_047431124.1:393..7109"
                     /db_xref="GeneID:22990"
                     /db_xref="HGNC:HGNC:19740"
                     /db_xref="MIM:617655"
ORIGIN      
        1 mgsqtlqilr qgvwaalsgg wyydphqatf vnalhlylwl fllglpftly malpstmiiv
       61 avycpviaav fivlkmvnyr lhraldagev vdrtaneftd qrtkaeqgnc strrkdsngp
      121 sdpgggiems efireatppv gcssrnsyag ldpsnqigsg ssrlgtaati kgdtdtakts
      181 ddislslgqs sslckegsee qdlaadrklf rlvsndsfis iqpslsscgq dlprdfsdkv
      241 nlpshnhhhh vdqslssacd tevaslvplh shsyrkdhrp rgvprtsssa vafpdtslnd
      301 fplyqqrrgl dpvselessk plsgskeslv ensglsgefq lagdlkints qpptksgksk
      361 plkaeksmds lrslstrssg stesycsgtd rdtnstvssy kseqtssthi esilsehees
      421 pkagtksgrk keccagpeek nscasdkrts sekiameast nsgvheakdp tpsdemhnqr
      481 glstsaseea nknphaneft sqgdrppgnt aenkeeksdk savsvdskvr kdvggkqkeg
      541 dvrpksssvi hrtasahksg rrrtgkkras sfdssrhrdy vcfrgvsgtk phsaifchde
      601 dssdqsdlsr assvqsahqf ssdsssstts hscqspegry salktkhthk ergtdsehth
      661 kahlvpegts kkratrrtss tnsaktrarv lsldsgtvac lndsnrlmap esikplttsk
      721 sdleakegev ldelsllgra sqletvtrsr nslpnqvafp egeeqdavsg gkfsstlyet
      781 ggcdmslvnf epaarrasni cdtdshvsss tsvrfyphdv irlnrlltid tdlleqqdid
      841 lspdlaatyg pteeaaqkvk hyyrfwilpq lwiginfdrl tllalfdrnr eilenvlavi
      901 lailvaflgs illiqgffrd iwvfqfclvi ascqysllks vqpdsssprh ghnriiaysr
      961 pvyfciccgl iwlldygsrn ltatkfklyg itftnplvfi sardlvivft lcfpivffig
     1021 llpqvntfvm ylceqldihi fggnattsll aalysficsi vavallyglc ygalkdswdg
     1081 qhipvlfsif cgllvavsyh lsrqssdpsv lfslvqskif pkteeknped plsevkdplp
     1141 eklrnsvser lqsdlvvciv igvlyfaihv stvftvlqpa lkyvlytlvg fvgfvthyvl
     1201 pqvrkqlpwh cfshpllktl eynqyevril iytalldaat mmwfeklhvw llfvekniiy
     1261 plivlnelss saetiaspkk lntelgalmi tvaglkllrs sfssptyqyv tviftvlffk
     1321 fdyeafsetm lldlffmsil fnklwellyk lqfvytyiap wqitwgsafh afaqpfavph
     1381 samlfiqaav saffstplnp flgsaifits yvrpvkfwer dyntkrvdhs ntrlasqldr
     1441 npgsddnnln sifyehltrs lqhslcgdll lgrwgnystg dcfilasdyl nalvhlieig
     1501 nglvtfqlrg lefrgtycqq reveaitegv eedegfccce pghiphmlsf naafsqrwla
     1561 wevivtkyil egysitdnsa asmlqvfdlr kvlttyyvkg iiyyvttssk leewlanetm
     1621 qeglrlcadr nyvdvdptfn pnidedydhr lagisresfc viylnwieyc ssrrakpvdv
     1681 dkdsslvtlc yglcvlgrra lgtashhmss nlesflyglh alfkgdfris sirdewifad
     1741 mellrkvvvp girmsiklhq dhftspdeyd dptvlyeaiv sheknlviah egdpawrsav
     1801 lanspsllal rhvmddgtne ykiimlnrry lsfrvikvnk ecvrglwagq qqelvflrnr
     1861 npergsiqna kqalrnmins scdqpigypi fvsplttsys dsheqlkdil ggpislgnir
     1921 nfivstwhrl rkgcgagcns ggniedsdtg ggtsctgnna ttannphsnv tqgsignpgq
     1981 gsgtglhppv tsypptlgts hsshsvqsgl vrqsparasv asqssycyss rhsslrmstt
     2041 gfvpcrrsst sqislrnlps siqsrlsmvn qmepsgqsgl acvqhglpss ssssqsipac
     2101 khhtlvgfla teggqssatd aqpgntlspa nnshsrkaev iyrvqivdps qileginlsk
     2161 rkelqwpdeg irlkagrnsw kdwspqegme ghvihrwvpc srdpgtrshi dkavllvqid
     2221 dkyvtvietg vlelgaev
//
LOCUS       XP_016876585            2235 aa            linear   PRI 05-AUG-2025
DEFINITION  pecanex-like protein 1 isoform X11 [Homo sapiens].
ACCESSION   XP_016876585
VERSION     XP_016876585.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021096.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2235
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2235
                     /product="pecanex-like protein 1 isoform X11"
                     /calculated_mol_wt=247385
     Region          1676..1902
                     /region_name="Pecanex_C"
                     /note="Pecanex protein (C-terminus); pfam05041"
                     /db_xref="CDD:461533"
     CDS             1..2235
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /coded_by="XM_017021096.2:393..7100"
                     /db_xref="GeneID:22990"
                     /db_xref="HGNC:HGNC:19740"
                     /db_xref="MIM:617655"
ORIGIN      
        1 mgsqtlqilr qgvwaalsgg wyydphqatf vnalhlylwl fllglpftly malpstmiiv
       61 avycpviaav fivlkmvnyr lhraldagev vdrtaneftd qrtkaeqgnc strrkdsngp
      121 sdpgggiems efireatppv gcssrnsyag ldpsnqigsg ssrlgtaati kgdtdtakts
      181 ddislslgqs sslckegsee qdlaadrklf rlvsndsfis iqpslsscgq dlprdfsdkv
      241 nlpshnhhhh vdqslssacd tevaslvplh shsyrkdhrp rgvprtsssa vafpdtslnd
      301 fplyqqrrgl dpvselessk plsgskeslv ensglsgefq lagdlkints qpptksgksk
      361 plkaeksmds lrslstrssg stesycsgtd rdtnstvssy kseqtssthi esilsehees
      421 pkagtksgrk keccagpeek nscasdkrts sekiameast nsgvheakdp tpsdemhnqr
      481 glstsaseea nknphaneft sqgdrppgnt aenkeeksdk savsvdskvr kdvggkqkeg
      541 dvrpksssvi hrtasahksg rrrtgkkras sfdssrhrdy vcfrgvsgtk phsaifchde
      601 dssdqsdlsr assvqsahqf ssdsssstts hscqspegry salktkhthk ergtdsehth
      661 kahlvpegts kkratrrtss tnsaktrarv lsldsgtvac lndsnrlmap esikplttsk
      721 sdleakegev ldelsllgra sqletvtrsr nslpnqvafp egeeqdavsg gkfsstlyet
      781 ggcdmslvnf epaarrasni cdtdshvsss tsvrfyphdv lslpqirlnr lltidtdlle
      841 qqdidlspdl aatygpteea aqkvkhyyrf wilpqlwigi nfdrltllal fdrnreilen
      901 vlavilailv aflgsilliq gffrdiwvfq fclviascqy sllksvqpds ssprhghnri
      961 iaysrpvyfc iccgliwlld ygsrnltatk fklygitftn plvfisardl vivftlcfpi
     1021 vffigllpqv ntfvmylceq ldihifggna ttsllaalys ficsivaval lyglcygalk
     1081 dswdgqhipv lfsifcgllv avsyhlsrqs sdpsvlfslv qskifpktee knpedplsev
     1141 kdplpeklrn svserlqsdl vvcivigvly faihvstvft vlqpalkyvl ytlvgfvgfv
     1201 thyvlpqvrk qlpwhcfshp llktleynqy evrnaatmmw feklhvwllf vekniiypli
     1261 vlnelsssae tiaspkklnt elgalmitva glkllrssfs sptyqyvtvi ftvlffkfdy
     1321 eafsetmlld lffmsilfnk lwellyklqf vytyiapwqi twgsafhafa qpfavphsam
     1381 lfiqaavsaf fstplnpflg saifitsyvr pvkfwerdyn tkrvdhsntr lasqldrnpg
     1441 sddnnlnsif yehltrslqh slcgdlllgr wgnystgdcf ilasdylnal vhlieigngl
     1501 vtfqlrglef rgtycqqrev eaitegveed egfcccepgh iphmlsfnaa fsqrwlawev
     1561 ivtkyilegy sitdnsaasm lqvfdlrkvl ttyyvkgiiy yvttssklee wlanetmqeg
     1621 lrlcadrnyv dvdptfnpni dedydhrlag isresfcviy lnwieycssr rakpvdvdkd
     1681 sslvtlcygl cvlgrralgt ashhmssnle sflyglhalf kgdfrissir dewifadmel
     1741 lrkvvvpgir msiklhqdhf tspdeyddpt vlyeaivshe knlviahegd pawrsavlan
     1801 spsllalrhv mddgtneyki imlnrrylsf rvikvnkecv rglwagqqqe lvflrnrnpe
     1861 rgsiqnakqa lrnminsscd qpigypifvs plttsysdsh eqlkdilggp islgnirnfi
     1921 vstwhrlrkg cgagcnsggn iedsdtgggt sctgnnatta nnphsnvtqg signpgqgsg
     1981 tglhppvtsy pptlgtshss hsvqsglvrq sparasvasq ssycyssrhs slrmsttgfv
     2041 pcrrsstsqi slrnlpssiq srlsmvnqme psgqsglacv qhglpsssss sqsipackhh
     2101 tlvgflateg gqssatdaqp gntlspanns hsrkaeviyr vqivdpsqil eginlskrke
     2161 lqwpdegirl kagrnswkdw spqegmeghv ihrwvpcsrd pgtrshidka vllvqiddky
     2221 vtvietgvle lgaev
//
LOCUS       XP_047287081            2206 aa            linear   PRI 05-AUG-2025
DEFINITION  pecanex-like protein 1 isoform X12 [Homo sapiens].
ACCESSION   XP_047287081
VERSION     XP_047287081.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431125.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2206
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2206
                     /product="pecanex-like protein 1 isoform X12"
                     /calculated_mol_wt=244108
     Region          1647..1873
                     /region_name="Pecanex_C"
                     /note="Pecanex protein (C-terminus); pfam05041"
                     /db_xref="CDD:461533"
     CDS             1..2206
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /coded_by="XM_047431125.1:12636..19256"
                     /db_xref="GeneID:22990"
                     /db_xref="HGNC:HGNC:19740"
                     /db_xref="MIM:617655"
ORIGIN      
        1 mgmktkyifh niiqalpstm iivavycpvi aavfivlkmv nyrlhralda gevvdrtane
       61 ftdqrtkaeq gncstrrkds ngpsdpgggi emsefireat ppvgcssrns yagldpsnqi
      121 gsgssrlgta atikgdtdta ktsddislsl gqssslckeg seeqdlaadr klfrlvsnds
      181 fisiqpslss cgqdlprdfs dkvnlpshnh hhhvdqslss acdtevaslv plhshsyrkd
      241 hrprgvprts ssavafpdts lndfplyqqr rgldpvsele sskplsgske slvensglsg
      301 efqlagdlki ntsqpptksg kskplkaeks mdslrslstr ssgstesycs gtdrdtnstv
      361 ssykseqtss thiesilseh eespkagtks grkkeccagp eeknscasdk rtssekiame
      421 astnsgvhea kdptpsdemh nqrglstsas eeanknphan eftsqgdrpp gntaenkeek
      481 sdksavsvds kvrkdvggkq kegdvrpkss svihrtasah ksgrrrtgkk rassfdssrh
      541 rdyvcfrgvs gtkphsaifc hdedssdqsd lsrassvqsa hqfssdssss ttshscqspe
      601 grysalktkh thkergtdse hthkahlvpe gtskkratrr tsstnsaktr arvlsldsgt
      661 vaclndsnrl mapesikplt tsksdleake gevldelsll grasqletvt rsrnslpnqv
      721 afpegeeqda vsggkfsstl yetggcdmsl vnfepaarra snicdtdshv ssstsvrfyp
      781 hdvlslpqir lnrlltidtd lleqqdidls pdlaatygpt eeaaqkvkhy yrfwilpqlw
      841 iginfdrltl lalfdrnrei lenvlavila ilvaflgsil liqgffrdiw vfqfclvias
      901 cqysllksvq pdsssprhgh nriiaysrpv yfciccgliw lldygsrnlt atkfklygit
      961 ftnplvfisa rdlvivftlc fpivffigll pqvntfvmyl ceqldihifg gnattsllaa
     1021 lysficsiva vallyglcyg alkdswdgqh ipvlfsifcg llvavsyhls rqssdpsvlf
     1081 slvqskifpk teeknpedpl sevkdplpek lrnsvserlq sdlvvcivig vlyfaihvst
     1141 vftvlqpalk yvlytlvgfv gfvthyvlpq vrkqlpwhcf shpllktley nqyevriliy
     1201 talldaatmm wfeklhvwll fvekniiypl ivlnelsssa etiaspkkln telgalmitv
     1261 aglkllrssf ssptyqyvtv iftvlffkfd yeafsetmll dlffmsilfn klwellyklq
     1321 fvytyiapwq itwgsafhaf aqpfavphsa mlfiqaavsa ffstplnpfl gsaifitsyv
     1381 rpvkfwerdy ntkrvdhsnt rlasqldrnp gsddnnlnsi fyehltrslq hslcgdlllg
     1441 rwgnystgdc filasdylna lvhlieigng lvtfqlrgle frgtycqqre veaitegvee
     1501 degfcccepg hiphmlsfna afsqrwlawe vivtkyileg ysitdnsaas mlqvfdlrkv
     1561 lttyyvkgii yyvttsskle ewlanetmqe glrlcadrny vdvdptfnpn idedydhrla
     1621 gisresfcvi ylnwieycss rrakpvdvdk dsslvtlcyg lcvlgrralg tashhmssnl
     1681 esflyglhal fkgdfrissi rdewifadme llrkvvvpgi rmsiklhqdh ftspdeyddp
     1741 tvlyeaivsh eknlviaheg dpawrsavla nspsllalrh vmddgtneyk iimlnrryls
     1801 frvikvnkec vrglwagqqq elvflrnrnp ergsiqnakq alrnminssc dqpigypifv
     1861 splttsysds heqlkdilgg pislgnirnf ivstwhrlrk gcgagcnsgg niedsdtggg
     1921 tsctgnnatt annphsnvtq gsignpgqgs gtglhppvts ypptlgtshs shsvqsglvr
     1981 qsparasvas qssycyssrh sslrmsttgf vpcrrsstsq islrnlpssi qsrlsmvnqm
     2041 epsgqsglac vqhglpssss ssqsipackh htlvgflate ggqssatdaq pgntlspann
     2101 shsrkaeviy rvqivdpsqi leginlskrk elqwpdegir lkagrnswkd wspqegmegh
     2161 vihrwvpcsr dpgtrshidk avllvqiddk yvtvietgvl elgaev
//
LOCUS       XP_047287082            2198 aa            linear   PRI 05-AUG-2025
DEFINITION  pecanex-like protein 1 isoform X13 [Homo sapiens].
ACCESSION   XP_047287082
VERSION     XP_047287082.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431126.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2198
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2198
                     /product="pecanex-like protein 1 isoform X13"
                     /calculated_mol_wt=243206
     Region          1639..1865
                     /region_name="Pecanex_C"
                     /note="Pecanex protein (C-terminus); pfam05041"
                     /db_xref="CDD:461533"
     CDS             1..2198
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /coded_by="XM_047431126.1:12636..19232"
                     /db_xref="GeneID:22990"
                     /db_xref="HGNC:HGNC:19740"
                     /db_xref="MIM:617655"
ORIGIN      
        1 mgmktkyifh niiqalpstm iivavycpvi aavfivlkmv nyrlhralda gevvdrtane
       61 ftdqrtkaeq gncstrrkds ngpsdpgggi emsefireat ppvgcssrns yagldpsnqi
      121 gsgssrlgta atikgdtdta ktsddislsl gqssslckeg seeqdlaadr klfrlvsnds
      181 fisiqpslss cgqdlprdfs dkvnlpshnh hhhvdqslss acdtevaslv plhshsyrkd
      241 hrprgvprts ssavafpdts lndfplyqqr rgldpvsele sskplsgske slvensglsg
      301 efqlagdlki ntsqpptksg kskplkaeks mdslrslstr ssgstesycs gtdrdtnstv
      361 ssykseqtss thiesilseh eespkagtks grkkeccagp eeknscasdk rtssekiame
      421 astnsgvhea kdptpsdemh nqrglstsas eeanknphan eftsqgdrpp gntaenkeek
      481 sdksavsvds kvrkdvggkq kegdvrpkss svihrtasah ksgrrrtgkk rassfdssrh
      541 rdyvcfrgvs gtkphsaifc hdedssdqsd lsrassvqsa hqfssdssss ttshscqspe
      601 grysalktkh thkergtdse hthkahlvpe gtskkratrr tsstnsaktr arvlsldsgt
      661 vaclndsnrl mapesikplt tsksdleake gevldelsll grasqletvt rsrnslpnqv
      721 afpegeeqda vsggkfsstl yetggcdmsl vnfepaarra snicdtdshv ssstsvrfyp
      781 hdvlslpqir lnrlltidtd lleqqdidls pdlaatygpt eeaaqkvkhy yrfwilpqlw
      841 iginfdrltl lalfdrnrei lenvlavila ilvaflgsil liqgffrdiw vfqfclvias
      901 cqysllksvq pdsssprhgh nriiaysrpv yfciccgliw lldygsrnlt atkfklygit
      961 ftnplvfisa rdlvivftlc fpivffigll pqvntfvmyl ceqldihifg gnattsllaa
     1021 lysficsiva vallyglcyg alkdswdgqh ipvlfsifcg llvavsyhls rqssdpsvlf
     1081 slvqskifpk teeknpedpl sevkdplpek lrnsvserlq sdlvvcivig vlyfaihvst
     1141 vftvlqpalk yvlytlvgfv gfvthyvlpq vrkqlpwhcf shpllktley nqyevrnaat
     1201 mmwfeklhvw llfvekniiy plivlnelss saetiaspkk lntelgalmi tvaglkllrs
     1261 sfssptyqyv tviftvlffk fdyeafsetm lldlffmsil fnklwellyk lqfvytyiap
     1321 wqitwgsafh afaqpfavph samlfiqaav saffstplnp flgsaifits yvrpvkfwer
     1381 dyntkrvdhs ntrlasqldr npgsddnnln sifyehltrs lqhslcgdll lgrwgnystg
     1441 dcfilasdyl nalvhlieig nglvtfqlrg lefrgtycqq reveaitegv eedegfccce
     1501 pghiphmlsf naafsqrwla wevivtkyil egysitdnsa asmlqvfdlr kvlttyyvkg
     1561 iiyyvttssk leewlanetm qeglrlcadr nyvdvdptfn pnidedydhr lagisresfc
     1621 viylnwieyc ssrrakpvdv dkdsslvtlc yglcvlgrra lgtashhmss nlesflyglh
     1681 alfkgdfris sirdewifad mellrkvvvp girmsiklhq dhftspdeyd dptvlyeaiv
     1741 sheknlviah egdpawrsav lanspsllal rhvmddgtne ykiimlnrry lsfrvikvnk
     1801 ecvrglwagq qqelvflrnr npergsiqna kqalrnmins scdqpigypi fvsplttsys
     1861 dsheqlkdil ggpislgnir nfivstwhrl rkgcgagcns ggniedsdtg ggtsctgnna
     1921 ttannphsnv tqgsignpgq gsgtglhppv tsypptlgts hsshsvqsgl vrqsparasv
     1981 asqssycyss rhsslrmstt gfvpcrrsst sqislrnlps siqsrlsmvn qmepsgqsgl
     2041 acvqhglpss ssssqsipac khhtlvgfla teggqssatd aqpgntlspa nnshsrkaev
     2101 iyrvqivdps qileginlsk rkelqwpdeg irlkagrnsw kdwspqegme ghvihrwvpc
     2161 srdpgtrshi dkavllvqid dkyvtvietg vlelgaev
//
LOCUS       XP_047287083            1982 aa            linear   PRI 05-AUG-2025
DEFINITION  pecanex-like protein 1 isoform X14 [Homo sapiens].
ACCESSION   XP_047287083
VERSION     XP_047287083.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431127.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1982
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1982
                     /product="pecanex-like protein 1 isoform X14"
                     /calculated_mol_wt=219680
     Region          1423..1649
                     /region_name="Pecanex_C"
                     /note="Pecanex protein (C-terminus); pfam05041"
                     /db_xref="CDD:461533"
     CDS             1..1982
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /coded_by="XM_047431127.1:590..6538"
                     /db_xref="GeneID:22990"
                     /db_xref="HGNC:HGNC:19740"
                     /db_xref="MIM:617655"
ORIGIN      
        1 mdslrslstr ssgstesycs gtdrdtnstv ssykseqtss thiesilseh eespkagtks
       61 grkkeccagp eeknscasdk rtssekiame astnsgvhea kdptpsdemh nqrglstsas
      121 eeanknphan eftsqgdrpp gntaenkeek sdksavsvds kvrkdvggkq kegdvrpkss
      181 svihrtasah ksgrrrtgkk rassfdssrh rdyvcfrgvs gtkphsaifc hdedssdqsd
      241 lsrassvqsa hqfssdssss ttshscqspe grysalktkh thkergtdse hthkahlvpe
      301 gtskkratrr tsstnsaktr arvlsldsgt vaclndsnrl mapesikplt tsksdleake
      361 gevldelsll grasqletvt rsrnslpnqv afpegeeqda vsgaaqasee avsfrrerst
      421 frrqavrrrh nagsnptppt lligsplslq dgqqgqqsta qvkvqsrpps qaavlsasas
      481 llvrngsvhl eashdnasav ggsslhdelg kfsstlyetg gcdmslvnfe paarrasnic
      541 dtdshvssst svrfyphdvl slpqirlnrl ltidtdlleq qdidlspdla atygpteeaa
      601 qkvkhyyrfw ilpqlwigin fdrltllalf drnreilenv lavilailva flgsilliqg
      661 ffrdiwvfqf clviascqys llksvqpdss sprhghnrii aysrpvyfci ccgliwlldy
      721 gsrnltatkf klygitftnp lvfisardlv ivftlcfpiv ffigllpqvn tfvmylceql
      781 dihifggnat tsllaalysf icsivavall yglcygalkd swdgqhipvl fsifcgllva
      841 vsyhlsrqss dpsvlfslvq skifpkteek npedplsevk dplpeklrns vserlqsdlv
      901 vcivigvlyf aihvstvftv lqpalkyvly tlvgfvgfvt hyvlpqvrkq lpwhcfshpl
      961 lktleynqye vriliytall daatmmwfek lhvwllfvek niiyplivln elsssaetia
     1021 spkklntelg almitvaglk llrssfsspt yqyvtviftv lffkfdyeaf setmlldlff
     1081 msilfnklwe llyklqfvyt yiapwqitwg safhafaqpf avphsamlfi qaavsaffst
     1141 plnpflgsai fitsyvrpvk fwerdyntkr vdhsntrlas qldrnpgsdd nnlnsifyeh
     1201 ltrslqhslc gdlllgrwgn ystgdcfila sdylnalvhl ieignglvtf qlrglefrgt
     1261 ycqqreveai tegveedegf cccepghiph mlsfnaafsq rwlawevivt kyilegysit
     1321 dnsaasmlqv fdlrkvltty yvkgiiyyvt tsskleewla netmqeglrl cadrnyvdvd
     1381 ptfnpnided ydhrlagisr esfcviylnw ieycssrrak pvdvdkdssl vtlcyglcvl
     1441 grralgtash hmssnlesfl yglhalfkgd frissirdew ifadmellrk vvvpgirmsi
     1501 klhqdhftsp deyddptvly eaivsheknl viahegdpaw rsavlansps llalrhvmdd
     1561 gtneykiiml nrrylsfrvi kvnkecvrgl wagqqqelvf lrnrnpergs iqnakqalrn
     1621 minsscdqpi gypifvsplt tsysdsheql kdilggpisl gnirnfivst whrlrkgcga
     1681 gcnsggnied sdtgggtsct gnnattannp hsnvtqgsig npgqgsgtgl hppvtsyppt
     1741 lgtshsshsv qsglvrqspa rasvasqssy cyssrhsslr msttgfvpcr rsstsqislr
     1801 nlpssiqsrl smvnqmepsg qsglacvqhg lpssssssqs ipackhhtlv gflateggqs
     1861 satdaqpgnt lspannshsr kaeviyrvqi vdpsqilegi nlskrkelqw pdegirlkag
     1921 rnswkdwspq egmeghvihr wvpcsrdpgt rshidkavll vqiddkyvtv ietgvlelga
     1981 ev
//
LOCUS       XP_047287084            1876 aa            linear   PRI 05-AUG-2025
DEFINITION  pecanex-like protein 1 isoform X15 [Homo sapiens].
ACCESSION   XP_047287084
VERSION     XP_047287084.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431128.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1876
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1876
                     /product="pecanex-like protein 1 isoform X15"
                     /calculated_mol_wt=208519
     Region          1317..1543
                     /region_name="Pecanex_C"
                     /note="Pecanex protein (C-terminus); pfam05041"
                     /db_xref="CDD:461533"
     CDS             1..1876
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /coded_by="XM_047431128.1:590..6220"
                     /db_xref="GeneID:22990"
                     /db_xref="HGNC:HGNC:19740"
                     /db_xref="MIM:617655"
ORIGIN      
        1 mdslrslstr ssgstesycs gtdrdtnstv ssykseqtss thiesilseh eespkagtks
       61 grkkeccagp eeknscasdk rtssekiame astnsgvhea kdptpsdemh nqrglstsas
      121 eeanknphan eftsqgdrpp gntaenkeek sdksavsvds kvrkdvggkq kegdvrpkss
      181 svihrtasah ksgrrrtgkk rassfdssrh rdyvcfrgvs gtkphsaifc hdedssdqsd
      241 lsrassvqsa hqfssdssss ttshscqspe grysalktkh thkergtdse hthkahlvpe
      301 gtskkratrr tsstnsaktr arvlsldsgt vaclndsnrl mapesikplt tsksdleake
      361 gevldelsll grasqletvt rsrnslpnqv afpegeeqda vsggkfsstl yetggcdmsl
      421 vnfepaarra snicdtdshv ssstsvrfyp hdvlslpqir lnrlltidtd lleqqdidls
      481 pdlaatygpt eeaaqkvkhy yrfwilpqlw iginfdrltl lalfdrnrei lenvlavila
      541 ilvaflgsil liqgffrdiw vfqfclvias cqysllksvq pdsssprhgh nriiaysrpv
      601 yfciccgliw lldygsrnlt atkfklygit ftnplvfisa rdlvivftlc fpivffigll
      661 pqvntfvmyl ceqldihifg gnattsllaa lysficsiva vallyglcyg alkdswdgqh
      721 ipvlfsifcg llvavsyhls rqssdpsvlf slvqskifpk teeknpedpl sevkdplpek
      781 lrnsvserlq sdlvvcivig vlyfaihvst vftvlqpalk yvlytlvgfv gfvthyvlpq
      841 vrkqlpwhcf shpllktley nqyevriliy talldaatmm wfeklhvwll fvekniiypl
      901 ivlnelsssa etiaspkkln telgalmitv aglkllrssf ssptyqyvtv iftvlffkfd
      961 yeafsetmll dlffmsilfn klwellyklq fvytyiapwq itwgsafhaf aqpfavphsa
     1021 mlfiqaavsa ffstplnpfl gsaifitsyv rpvkfwerdy ntkrvdhsnt rlasqldrnp
     1081 gsddnnlnsi fyehltrslq hslcgdlllg rwgnystgdc filasdylna lvhlieigng
     1141 lvtfqlrgle frgtycqqre veaitegvee degfcccepg hiphmlsfna afsqrwlawe
     1201 vivtkyileg ysitdnsaas mlqvfdlrkv lttyyvkgii yyvttsskle ewlanetmqe
     1261 glrlcadrny vdvdptfnpn idedydhrla gisresfcvi ylnwieycss rrakpvdvdk
     1321 dsslvtlcyg lcvlgrralg tashhmssnl esflyglhal fkgdfrissi rdewifadme
     1381 llrkvvvpgi rmsiklhqdh ftspdeyddp tvlyeaivsh eknlviaheg dpawrsavla
     1441 nspsllalrh vmddgtneyk iimlnrryls frvikvnkec vrglwagqqq elvflrnrnp
     1501 ergsiqnakq alrnminssc dqpigypifv splttsysds heqlkdilgg pislgnirnf
     1561 ivstwhrlrk gcgagcnsgg niedsdtggg tsctgnnatt annphsnvtq gsignpgqgs
     1621 gtglhppvts ypptlgtshs shsvqsglvr qsparasvas qssycyssrh sslrmsttgf
     1681 vpcrrsstsq islrnlpssi qsrlsmvnqm epsgqsglac vqhglpssss ssqsipackh
     1741 htlvgflate ggqssatdaq pgntlspann shsrkaeviy rvqivdpsqi leginlskrk
     1801 elqwpdegir lkagrnswkd wspqegmegh vihrwvpcsr dpgtrshidk avllvqiddk
     1861 yvtvietgvl elgaev
//
LOCUS       XP_047287085            1868 aa            linear   PRI 05-AUG-2025
DEFINITION  pecanex-like protein 1 isoform X16 [Homo sapiens].
ACCESSION   XP_047287085
VERSION     XP_047287085.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431129.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1868
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1868
                     /product="pecanex-like protein 1 isoform X16"
                     /calculated_mol_wt=207617
     Region          1309..1535
                     /region_name="Pecanex_C"
                     /note="Pecanex protein (C-terminus); pfam05041"
                     /db_xref="CDD:461533"
     CDS             1..1868
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /coded_by="XM_047431129.1:590..6196"
                     /db_xref="GeneID:22990"
                     /db_xref="HGNC:HGNC:19740"
                     /db_xref="MIM:617655"
ORIGIN      
        1 mdslrslstr ssgstesycs gtdrdtnstv ssykseqtss thiesilseh eespkagtks
       61 grkkeccagp eeknscasdk rtssekiame astnsgvhea kdptpsdemh nqrglstsas
      121 eeanknphan eftsqgdrpp gntaenkeek sdksavsvds kvrkdvggkq kegdvrpkss
      181 svihrtasah ksgrrrtgkk rassfdssrh rdyvcfrgvs gtkphsaifc hdedssdqsd
      241 lsrassvqsa hqfssdssss ttshscqspe grysalktkh thkergtdse hthkahlvpe
      301 gtskkratrr tsstnsaktr arvlsldsgt vaclndsnrl mapesikplt tsksdleake
      361 gevldelsll grasqletvt rsrnslpnqv afpegeeqda vsggkfsstl yetggcdmsl
      421 vnfepaarra snicdtdshv ssstsvrfyp hdvlslpqir lnrlltidtd lleqqdidls
      481 pdlaatygpt eeaaqkvkhy yrfwilpqlw iginfdrltl lalfdrnrei lenvlavila
      541 ilvaflgsil liqgffrdiw vfqfclvias cqysllksvq pdsssprhgh nriiaysrpv
      601 yfciccgliw lldygsrnlt atkfklygit ftnplvfisa rdlvivftlc fpivffigll
      661 pqvntfvmyl ceqldihifg gnattsllaa lysficsiva vallyglcyg alkdswdgqh
      721 ipvlfsifcg llvavsyhls rqssdpsvlf slvqskifpk teeknpedpl sevkdplpek
      781 lrnsvserlq sdlvvcivig vlyfaihvst vftvlqpalk yvlytlvgfv gfvthyvlpq
      841 vrkqlpwhcf shpllktley nqyevrnaat mmwfeklhvw llfvekniiy plivlnelss
      901 saetiaspkk lntelgalmi tvaglkllrs sfssptyqyv tviftvlffk fdyeafsetm
      961 lldlffmsil fnklwellyk lqfvytyiap wqitwgsafh afaqpfavph samlfiqaav
     1021 saffstplnp flgsaifits yvrpvkfwer dyntkrvdhs ntrlasqldr npgsddnnln
     1081 sifyehltrs lqhslcgdll lgrwgnystg dcfilasdyl nalvhlieig nglvtfqlrg
     1141 lefrgtycqq reveaitegv eedegfccce pghiphmlsf naafsqrwla wevivtkyil
     1201 egysitdnsa asmlqvfdlr kvlttyyvkg iiyyvttssk leewlanetm qeglrlcadr
     1261 nyvdvdptfn pnidedydhr lagisresfc viylnwieyc ssrrakpvdv dkdsslvtlc
     1321 yglcvlgrra lgtashhmss nlesflyglh alfkgdfris sirdewifad mellrkvvvp
     1381 girmsiklhq dhftspdeyd dptvlyeaiv sheknlviah egdpawrsav lanspsllal
     1441 rhvmddgtne ykiimlnrry lsfrvikvnk ecvrglwagq qqelvflrnr npergsiqna
     1501 kqalrnmins scdqpigypi fvsplttsys dsheqlkdil ggpislgnir nfivstwhrl
     1561 rkgcgagcns ggniedsdtg ggtsctgnna ttannphsnv tqgsignpgq gsgtglhppv
     1621 tsypptlgts hsshsvqsgl vrqsparasv asqssycyss rhsslrmstt gfvpcrrsst
     1681 sqislrnlps siqsrlsmvn qmepsgqsgl acvqhglpss ssssqsipac khhtlvgfla
     1741 teggqssatd aqpgntlspa nnshsrkaev iyrvqivdps qileginlsk rkelqwpdeg
     1801 irlkagrnsw kdwspqegme ghvihrwvpc srdpgtrshi dkavllvqid dkyvtvietg
     1861 vlelgaev
//
LOCUS       XP_005267484            1515 aa            linear   PRI 05-AUG-2025
DEFINITION  pecanex-like protein 1 isoform X17 [Homo sapiens].
ACCESSION   XP_005267484
VERSION     XP_005267484.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267427.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1515
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1515
                     /product="pecanex-like protein 1 isoform X17"
                     /calculated_mol_wt=166677
     CDS             1..1515
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /coded_by="XM_005267427.5:393..4940"
                     /db_xref="GeneID:22990"
                     /db_xref="HGNC:HGNC:19740"
                     /db_xref="MIM:617655"
ORIGIN      
        1 mgsqtlqilr qgvwaalsgg wyydphqatf vnalhlylwl fllglpftly malpstmiiv
       61 avycpviaav fivlkmvnyr lhraldagev vdrtaneftd qrtkaeqgnc strrkdsngp
      121 sdpgggiems efireatppv gcssrnsyag ldpsnqigsg ssrlgtaati kgdtdtakts
      181 ddislslgqs sslckegsee qdlaadrklf rlvsndsfis iqpslsscgq dlprdfsdkv
      241 nlpshnhhhh vdqslssacd tevaslvplh shsyrkdhrp rgvprtsssa vafpdtslnd
      301 fplyqqrrgl dpvselessk plsgskeslv ensglsgefq lagdlkints qpptksgksk
      361 plkaeksmds lrslstrssg stesycsgtd rdtnstvssy kseqtssthi esilsehees
      421 pkagtksgrk keccagpeek nscasdkrts sekiameast nsgvheakdp tpsdemhnqr
      481 glstsaseea nknphaneft sqgdrppgnt aenkeeksdk savsvdskvr kdvggkqkeg
      541 dvrpksssvi hrtasahksg rrrtgkkras sfdssrhrdy vcfrgvsgtk phsaifchde
      601 dssdqsdlsr assvqsahqf ssdsssstts hscqspegry salktkhthk ergtdsehth
      661 kahlvpegts kkratrrtss tnsaktrarv lsldsgtvac lndsnrlmap esikplttsk
      721 sdleakegev ldelsllgra sqletvtrsr nslpnqvafp egeeqdavsg aaqaseeavs
      781 frrerstfrr qavrrrhnag snptpptlli gsplslqdgq qgqqstaqvk vqsrppsqaa
      841 vlsasasllv rngsvhleas hdnasavggs slhdelgkfs stlyetggcd mslvnfepaa
      901 rrasnicdtd shvssstsvr fyphdvlslp qirlnrllti dtdlleqqdi dlspdlaaty
      961 gpteeaaqkv khyyrfwilp qlwiginfdr ltllalfdrn reilenvlav ilailvaflg
     1021 silliqgffr diwvfqfclv iascqysllk svqpdssspr hghnriiays rpvyfciccg
     1081 liwlldygsr nltatkfkly gitftnplvf isardlvivf tlcfpivffi gllpqvntfv
     1141 mylceqldih ifggnattsl laalysfics ivavallygl cygalkdswd gqhipvlfsi
     1201 fcgllvavsy hlsrqssdps vlfslvqski fpkteeknpe dplsevkdpl peklrnsvse
     1261 rlqsdlvvci vigvlyfaih vstvftvlqp alkyvlytlv gfvgfvthyv lpqvrkqlpw
     1321 hcfshpllkt leynqyevri liytalldaa tmmwfeklhv wllfveknii yplivlnels
     1381 ssaetiaspk klntelgalm itvaglkllr ssfssptyqy vtviftvlff kfdyeafset
     1441 mlldlffmsi lfnkpffssc sfgnyfincs lcipilphgr shgvllsmll lsllqcliqp
     1501 cclfrllsrp ssllh
//
LOCUS       XP_047287086            1469 aa            linear   PRI 05-AUG-2025
DEFINITION  pecanex-like protein 1 isoform X18 [Homo sapiens].
ACCESSION   XP_047287086
VERSION     XP_047287086.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431130.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1469
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1469
                     /product="pecanex-like protein 1 isoform X18"
                     /calculated_mol_wt=161536
     CDS             1..1469
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /coded_by="XM_047431130.1:393..4802"
                     /db_xref="GeneID:22990"
                     /db_xref="HGNC:HGNC:19740"
                     /db_xref="MIM:617655"
ORIGIN      
        1 mgsqtlqilr qgvwaalsgg wyydphqatf vnalhlylwl fllglpftly malpstmiiv
       61 avycpviaav fivlkmvnyr lhraldagev vdrtaneftd qrtkaeqgnc strrkdsngp
      121 sdpgggiems efireatppv gcssrnsyag ldpsnqigsg ssrlgtaati kgdtdtakts
      181 ddislslgqs sslckegsee qdlaadrklf rlvsndsfis iqpslsscgq dlprdfsdkv
      241 nlpshnhhhh vdqslssacd tevaslvplh shsyrkdhrp rgvprtsssa vafpdtslnd
      301 fplyqqrrgl dpvselessk plsgskeslv ensglsgefq lagdlkints qpptksgksk
      361 plkaeksmds lrslstrssg stesycsgtd rdtnstvssy kseqtssthi esilsehees
      421 pkagtksgrk keccagpeek nscasdkrts sekiameast nsgvheakdp tpsdemhnqr
      481 glstsaseea nknphaneft sqgdrppgnt aenkeeksdk savsvdskvr kdvggkqkeg
      541 dvrpksssvi hrtasahksg rrrtgkkras sfdssrhrdy vcfrgvsgtk phsaifchde
      601 dssdqsdlsr assvqsahqf ssdsssstts hscqspegry salktkhthk ergtdsehth
      661 kahlvpegts kkratrrtss tnsaktrarv lsldsgtvac lndsnrlmap esikplttsk
      721 sdleakegev ldelsllgra sqletvtrsr nslpnqvafp egeeqdavsg aaqaseeavs
      781 frrerstfrr qavrrrhnag snptpptlli gsplslqdgq qgqqstaqvk vqsrppsqaa
      841 vlsasasllv rngsvhleas hdnasavggs slhdelgkfs stlyetggcd mslvnfepaa
      901 rrasnicdtd shvssstsvr fyphdvlslp qirlnrllti dtdlleqqdi dlspdlaaty
      961 gpteeaaqkv khyyrfwilp qlwiginfdr ltllalfdrn reilenvlav ilailvaflg
     1021 silliqgffr diwvfqfclv iascqysllk svqpdssspr hghnriiays rpvyfciccg
     1081 liwlldygsr nltatkfkly gitftnplvf isardlvivf tlcfpivffi gllpqvntfv
     1141 mylceqldih ifggnattsl laalysfics ivavallygl cygalkdswd gqhipvlfsi
     1201 fcgllvavsy hlsrqssdps vlfslvqski fpkteeknpe dplsevkdpl peklrnsvse
     1261 rlqsdlvvci vigvlyfaih vstvftvlqp alkyvlytlv gfvgfvthyv lpqvrkqlpw
     1321 hcfshpllkt leynqyevri liytalldaa tmmwfeklhv wllfveknii yplivlnels
     1381 ssaetiaspk klntelgalm itvaglkllr ssfssptyqy vtviftvlff kfdyeafset
     1441 mlldlffmsi lfnkhktsgs fkyqigfpa
//
LOCUS       XP_047287087            1459 aa            linear   PRI 05-AUG-2025
DEFINITION  pecanex-like protein 1 isoform X19 [Homo sapiens].
ACCESSION   XP_047287087
VERSION     XP_047287087.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431131.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1459
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1459
                     /product="pecanex-like protein 1 isoform X19"
                     /calculated_mol_wt=163594
     Region          900..1126
                     /region_name="Pecanex_C"
                     /note="Pecanex protein (C-terminus); pfam05041"
                     /db_xref="CDD:461533"
     CDS             1..1459
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /coded_by="XM_047431131.1:98..4477"
                     /db_xref="GeneID:22990"
                     /db_xref="HGNC:HGNC:19740"
                     /db_xref="MIM:617655"
ORIGIN      
        1 mslvnfepaa rrasnicdtd shvssstsvr fyphdvlslp qirlnrllti dtdlleqqdi
       61 dlspdlaaty gpteeaaqkv khyyrfwilp qlwiginfdr ltllalfdrn reilenvlav
      121 ilailvaflg silliqgffr diwvfqfclv iascqysllk svqpdssspr hghnriiays
      181 rpvyfciccg liwlldygsr nltatkfkly gitftnplvf isardlvivf tlcfpivffi
      241 gllpqvntfv mylceqldih ifggnattsl laalysfics ivavallygl cygalkdswd
      301 gqhipvlfsi fcgllvavsy hlsrqssdps vlfslvqski fpkteeknpe dplsevkdpl
      361 peklrnsvse rlqsdlvvci vigvlyfaih vstvftvlqp alkyvlytlv gfvgfvthyv
      421 lpqvrkqlpw hcfshpllkt leynqyevri liytalldaa tmmwfeklhv wllfveknii
      481 yplivlnels ssaetiaspk klntelgalm itvaglkllr ssfssptyqy vtviftvlff
      541 kfdyeafset mlldlffmsi lfnklwelly klqfvytyia pwqitwgsaf hafaqpfavp
      601 hsamlfiqaa vsaffstpln pflgsaifit syvrpvkfwe rdyntkrvdh sntrlasqld
      661 rnpgsddnnl nsifyehltr slqhslcgdl llgrwgnyst gdcfilasdy lnalvhliei
      721 gnglvtfqlr glefrgtycq qreveaiteg veedegfccc epghiphmls fnaafsqrwl
      781 awevivtkyi legysitdns aasmlqvfdl rkvlttyyvk giiyyvttss kleewlanet
      841 mqeglrlcad rnyvdvdptf npnidedydh rlagisresf cviylnwiey cssrrakpvd
      901 vdkdsslvtl cyglcvlgrr algtashhms snlesflygl halfkgdfri ssirdewifa
      961 dmellrkvvv pgirmsiklh qdhftspdey ddptvlyeai vsheknlvia hegdpawrsa
     1021 vlanspslla lrhvmddgtn eykiimlnrr ylsfrvikvn kecvrglwag qqqelvflrn
     1081 rnpergsiqn akqalrnmin sscdqpigyp ifvsplttsy sdsheqlkdi lggpislgni
     1141 rnfivstwhr lrkgcgagcn sggniedsdt gggtsctgnn attannphsn vtqgsignpg
     1201 qgsgtglhpp vtsypptlgt shsshsvqsg lvrqsparas vasqssycys srhsslrmst
     1261 tgfvpcrrss tsqislrnlp ssiqsrlsmv nqmepsgqsg lacvqhglps sssssqsipa
     1321 ckhhtlvgfl ateggqssat daqpgntlsp annshsrkae viyrvqivdp sqileginls
     1381 krkelqwpde girlkagrns wkdwspqegm eghvihrwvp csrdpgtrsh idkavllvqi
     1441 ddkyvtviet gvlelgaev
//
LOCUS       XP_006720145            1423 aa            linear   PRI 05-AUG-2025
DEFINITION  pecanex-like protein 1 isoform X20 [Homo sapiens].
ACCESSION   XP_006720145
VERSION     XP_006720145.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720082.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1423
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1423
                     /product="pecanex-like protein 1 isoform X20"
                     /calculated_mol_wt=159651
     Region          864..1090
                     /region_name="Pecanex_C"
                     /note="Pecanex protein (C-terminus); pfam05041"
                     /db_xref="CDD:461533"
     CDS             1..1423
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /coded_by="XM_006720082.4:107..4378"
                     /db_xref="GeneID:22990"
                     /db_xref="HGNC:HGNC:19740"
                     /db_xref="MIM:617655"
ORIGIN      
        1 mqsveirlnr lltidtdlle qqdidlspdl aatygpteea aqkvkhyyrf wilpqlwigi
       61 nfdrltllal fdrnreilen vlavilailv aflgsilliq gffrdiwvfq fclviascqy
      121 sllksvqpds ssprhghnri iaysrpvyfc iccgliwlld ygsrnltatk fklygitftn
      181 plvfisardl vivftlcfpi vffigllpqv ntfvmylceq ldihifggna ttsllaalys
      241 ficsivaval lyglcygalk dswdgqhipv lfsifcgllv avsyhlsrqs sdpsvlfslv
      301 qskifpktee knpedplsev kdplpeklrn svserlqsdl vvcivigvly faihvstvft
      361 vlqpalkyvl ytlvgfvgfv thyvlpqvrk qlpwhcfshp llktleynqy evriliytal
      421 ldaatmmwfe klhvwllfve kniiyplivl nelsssaeti aspkklntel galmitvagl
      481 kllrssfssp tyqyvtvift vlffkfdyea fsetmlldlf fmsilfnklw ellyklqfvy
      541 tyiapwqitw gsafhafaqp favphsamlf iqaavsaffs tplnpflgsa ifitsyvrpv
      601 kfwerdyntk rvdhsntrla sqldrnpgsd dnnlnsifye hltrslqhsl cgdlllgrwg
      661 nystgdcfil asdylnalvh lieignglvt fqlrglefrg tycqqrevea itegveedeg
      721 fcccepghip hmlsfnaafs qrwlaweviv tkyilegysi tdnsaasmlq vfdlrkvltt
      781 yyvkgiiyyv ttsskleewl anetmqeglr lcadrnyvdv dptfnpnide dydhrlagis
      841 resfcviyln wieycssrra kpvdvdkdss lvtlcyglcv lgrralgtas hhmssnlesf
      901 lyglhalfkg dfrissirde wifadmellr kvvvpgirms iklhqdhfts pdeyddptvl
      961 yeaivshekn lviahegdpa wrsavlansp sllalrhvmd dgtneykiim lnrrylsfrv
     1021 ikvnkecvrg lwagqqqelv flrnrnperg siqnakqalr nminsscdqp igypifvspl
     1081 ttsysdsheq lkdilggpis lgnirnfivs twhrlrkgcg agcnsggnie dsdtgggtsc
     1141 tgnnattann phsnvtqgsi gnpgqgsgtg lhppvtsypp tlgtshsshs vqsglvrqsp
     1201 arasvasqss ycyssrhssl rmsttgfvpc rrsstsqisl rnlpssiqsr lsmvnqmeps
     1261 gqsglacvqh glpssssssq sipackhhtl vgflateggq ssatdaqpgn tlspannshs
     1321 rkaeviyrvq ivdpsqileg inlskrkelq wpdegirlka grnswkdwsp qegmeghvih
     1381 rwvpcsrdpg trshidkavl lvqiddkyvt vietgvlelg aev
//
LOCUS       XP_047287088            1421 aa            linear   PRI 05-AUG-2025
DEFINITION  pecanex-like protein 1 isoform X21 [Homo sapiens].
ACCESSION   XP_047287088
VERSION     XP_047287088.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431132.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1421
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1421
                     /product="pecanex-like protein 1 isoform X21"
                     /calculated_mol_wt=159435
     Region          862..1088
                     /region_name="Pecanex_C"
                     /note="Pecanex protein (C-terminus); pfam05041"
                     /db_xref="CDD:461533"
     CDS             1..1421
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /coded_by="XM_047431132.1:102..4367"
                     /db_xref="GeneID:22990"
                     /db_xref="HGNC:HGNC:19740"
                     /db_xref="MIM:617655"
ORIGIN      
        1 mnlirlnrll tidtdlleqq didlspdlaa tygpteeaaq kvkhyyrfwi lpqlwiginf
       61 drltllalfd rnreilenvl avilailvaf lgsilliqgf frdiwvfqfc lviascqysl
      121 lksvqpdsss prhghnriia ysrpvyfcic cgliwlldyg srnltatkfk lygitftnpl
      181 vfisardlvi vftlcfpivf figllpqvnt fvmylceqld ihifggnatt sllaalysfi
      241 csivavally glcygalkds wdgqhipvlf sifcgllvav syhlsrqssd psvlfslvqs
      301 kifpkteekn pedplsevkd plpeklrnsv serlqsdlvv civigvlyfa ihvstvftvl
      361 qpalkyvlyt lvgfvgfvth yvlpqvrkql pwhcfshpll ktleynqyev riliytalld
      421 aatmmwfekl hvwllfvekn iiyplivlne lsssaetias pkklntelga lmitvaglkl
      481 lrssfsspty qyvtviftvl ffkfdyeafs etmlldlffm silfnklwel lyklqfvyty
      541 iapwqitwgs afhafaqpfa vphsamlfiq aavsaffstp lnpflgsaif itsyvrpvkf
      601 werdyntkrv dhsntrlasq ldrnpgsddn nlnsifyehl trslqhslcg dlllgrwgny
      661 stgdcfilas dylnalvhli eignglvtfq lrglefrgty cqqreveait egveedegfc
      721 ccepghiphm lsfnaafsqr wlawevivtk yilegysitd nsaasmlqvf dlrkvlttyy
      781 vkgiiyyvtt sskleewlan etmqeglrlc adrnyvdvdp tfnpnidedy dhrlagisre
      841 sfcviylnwi eycssrrakp vdvdkdsslv tlcyglcvlg rralgtashh mssnlesfly
      901 glhalfkgdf rissirdewi fadmellrkv vvpgirmsik lhqdhftspd eyddptvlye
      961 aivsheknlv iahegdpawr savlanspsl lalrhvmddg tneykiimln rrylsfrvik
     1021 vnkecvrglw agqqqelvfl rnrnpergsi qnakqalrnm insscdqpig ypifvspltt
     1081 sysdsheqlk dilggpislg nirnfivstw hrlrkgcgag cnsggnieds dtgggtsctg
     1141 nnattannph snvtqgsign pgqgsgtglh ppvtsypptl gtshsshsvq sglvrqspar
     1201 asvasqssyc yssrhsslrm sttgfvpcrr sstsqislrn lpssiqsrls mvnqmepsgq
     1261 sglacvqhgl pssssssqsi packhhtlvg flateggqss atdaqpgntl spannshsrk
     1321 aeviyrvqiv dpsqilegin lskrkelqwp degirlkagr nswkdwspqe gmeghvihrw
     1381 vpcsrdpgtr shidkavllv qiddkyvtvi etgvlelgae v
//
LOCUS       XP_047287089            1415 aa            linear   PRI 05-AUG-2025
DEFINITION  pecanex-like protein 1 isoform X22 [Homo sapiens].
ACCESSION   XP_047287089
VERSION     XP_047287089.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431133.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1415
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1415
                     /product="pecanex-like protein 1 isoform X22"
                     /calculated_mol_wt=158749
     Region          856..1082
                     /region_name="Pecanex_C"
                     /note="Pecanex protein (C-terminus); pfam05041"
                     /db_xref="CDD:461533"
     CDS             1..1415
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /coded_by="XM_047431133.1:1373..5620"
                     /db_xref="GeneID:22990"
                     /db_xref="HGNC:HGNC:19740"
                     /db_xref="MIM:617655"
ORIGIN      
        1 mqsveirlnr lltidtdlle qqdidlspdl aatygpteea aqkvkhyyrf wilpqlwigi
       61 nfdrltllal fdrnreilen vlavilailv aflgsilliq gffrdiwvfq fclviascqy
      121 sllksvqpds ssprhghnri iaysrpvyfc iccgliwlld ygsrnltatk fklygitftn
      181 plvfisardl vivftlcfpi vffigllpqv ntfvmylceq ldihifggna ttsllaalys
      241 ficsivaval lyglcygalk dswdgqhipv lfsifcgllv avsyhlsrqs sdpsvlfslv
      301 qskifpktee knpedplsev kdplpeklrn svserlqsdl vvcivigvly faihvstvft
      361 vlqpalkyvl ytlvgfvgfv thyvlpqvrk qlpwhcfshp llktleynqy evrnaatmmw
      421 feklhvwllf vekniiypli vlnelsssae tiaspkklnt elgalmitva glkllrssfs
      481 sptyqyvtvi ftvlffkfdy eafsetmlld lffmsilfnk lwellyklqf vytyiapwqi
      541 twgsafhafa qpfavphsam lfiqaavsaf fstplnpflg saifitsyvr pvkfwerdyn
      601 tkrvdhsntr lasqldrnpg sddnnlnsif yehltrslqh slcgdlllgr wgnystgdcf
      661 ilasdylnal vhlieigngl vtfqlrglef rgtycqqrev eaitegveed egfcccepgh
      721 iphmlsfnaa fsqrwlawev ivtkyilegy sitdnsaasm lqvfdlrkvl ttyyvkgiiy
      781 yvttssklee wlanetmqeg lrlcadrnyv dvdptfnpni dedydhrlag isresfcviy
      841 lnwieycssr rakpvdvdkd sslvtlcygl cvlgrralgt ashhmssnle sflyglhalf
      901 kgdfrissir dewifadmel lrkvvvpgir msiklhqdhf tspdeyddpt vlyeaivshe
      961 knlviahegd pawrsavlan spsllalrhv mddgtneyki imlnrrylsf rvikvnkecv
     1021 rglwagqqqe lvflrnrnpe rgsiqnakqa lrnminsscd qpigypifvs plttsysdsh
     1081 eqlkdilggp islgnirnfi vstwhrlrkg cgagcnsggn iedsdtgggt sctgnnatta
     1141 nnphsnvtqg signpgqgsg tglhppvtsy pptlgtshss hsvqsglvrq sparasvasq
     1201 ssycyssrhs slrmsttgfv pcrrsstsqi slrnlpssiq srlsmvnqme psgqsglacv
     1261 qhglpsssss sqsipackhh tlvgflateg gqssatdaqp gntlspanns hsrkaeviyr
     1321 vqivdpsqil eginlskrke lqwpdegirl kagrnswkdw spqegmeghv ihrwvpcsrd
     1381 pgtrshidka vllvqiddky vtvietgvle lgaev
//
LOCUS       XP_047287090            1413 aa            linear   PRI 05-AUG-2025
DEFINITION  pecanex-like protein 1 isoform X23 [Homo sapiens].
ACCESSION   XP_047287090
VERSION     XP_047287090.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431134.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1413
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1413
                     /product="pecanex-like protein 1 isoform X23"
                     /calculated_mol_wt=158532
     Region          854..1080
                     /region_name="Pecanex_C"
                     /note="Pecanex protein (C-terminus); pfam05041"
                     /db_xref="CDD:461533"
     CDS             1..1413
                     /gene="PCNX1"
                     /gene_synonym="PCNX; PCNXL1; pecanex"
                     /coded_by="XM_047431134.1:177..4418"
                     /db_xref="GeneID:22990"
                     /db_xref="HGNC:HGNC:19740"
                     /db_xref="MIM:617655"
ORIGIN      
        1 mnlirlnrll tidtdlleqq didlspdlaa tygpteeaaq kvkhyyrfwi lpqlwiginf
       61 drltllalfd rnreilenvl avilailvaf lgsilliqgf frdiwvfqfc lviascqysl
      121 lksvqpdsss prhghnriia ysrpvyfcic cgliwlldyg srnltatkfk lygitftnpl
      181 vfisardlvi vftlcfpivf figllpqvnt fvmylceqld ihifggnatt sllaalysfi
      241 csivavally glcygalkds wdgqhipvlf sifcgllvav syhlsrqssd psvlfslvqs
      301 kifpkteekn pedplsevkd plpeklrnsv serlqsdlvv civigvlyfa ihvstvftvl
      361 qpalkyvlyt lvgfvgfvth yvlpqvrkql pwhcfshpll ktleynqyev rnaatmmwfe
      421 klhvwllfve kniiyplivl nelsssaeti aspkklntel galmitvagl kllrssfssp
      481 tyqyvtvift vlffkfdyea fsetmlldlf fmsilfnklw ellyklqfvy tyiapwqitw
      541 gsafhafaqp favphsamlf iqaavsaffs tplnpflgsa ifitsyvrpv kfwerdyntk
      601 rvdhsntrla sqldrnpgsd dnnlnsifye hltrslqhsl cgdlllgrwg nystgdcfil
      661 asdylnalvh lieignglvt fqlrglefrg tycqqrevea itegveedeg fcccepghip
      721 hmlsfnaafs qrwlaweviv tkyilegysi tdnsaasmlq vfdlrkvltt yyvkgiiyyv
      781 ttsskleewl anetmqeglr lcadrnyvdv dptfnpnide dydhrlagis resfcviyln
      841 wieycssrra kpvdvdkdss lvtlcyglcv lgrralgtas hhmssnlesf lyglhalfkg
      901 dfrissirde wifadmellr kvvvpgirms iklhqdhfts pdeyddptvl yeaivshekn
      961 lviahegdpa wrsavlansp sllalrhvmd dgtneykiim lnrrylsfrv ikvnkecvrg
     1021 lwagqqqelv flrnrnperg siqnakqalr nminsscdqp igypifvspl ttsysdsheq
     1081 lkdilggpis lgnirnfivs twhrlrkgcg agcnsggnie dsdtgggtsc tgnnattann
     1141 phsnvtqgsi gnpgqgsgtg lhppvtsypp tlgtshsshs vqsglvrqsp arasvasqss
     1201 ycyssrhssl rmsttgfvpc rrsstsqisl rnlpssiqsr lsmvnqmeps gqsglacvqh
     1261 glpssssssq sipackhhtl vgflateggq ssatdaqpgn tlspannshs rkaeviyrvq
     1321 ivdpsqileg inlskrkelq wpdegirlka grnswkdwsp qegmeghvih rwvpcsrdpg
     1381 trshidkavl lvqiddkyvt vietgvlelg aev
//
LOCUS       XP_005267487            1078 aa            linear   PRI 05-AUG-2025
DEFINITION  disheveled-associated activator of morphogenesis 1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_005267487
VERSION     XP_005267487.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267430.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1078
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1078
                     /product="disheveled-associated activator of morphogenesis
                     1 isoform X1"
                     /calculated_mol_wt=123343
     Region          45..232
                     /region_name="Drf_GBD"
                     /note="Diaphanous GTPase-binding Domain; pfam06371"
                     /db_xref="CDD:461886"
     Region          235..439
                     /region_name="Drf_FH3"
                     /note="Diaphanous FH3 Domain; pfam06367"
                     /db_xref="CDD:461885"
     Region          444..>513
                     /region_name="PRK12704"
                     /note="phosphodiesterase; Provisional"
                     /db_xref="CDD:237177"
     Region          600..984
                     /region_name="FH2"
                     /note="Formin Homology 2 Domain; pfam02181"
                     /db_xref="CDD:396655"
     CDS             1..1078
                     /gene="DAAM1"
                     /coded_by="XM_005267430.3:140..3376"
                     /db_xref="GeneID:23002"
                     /db_xref="HGNC:HGNC:18142"
                     /db_xref="MIM:606626"
ORIGIN      
        1 maprkrggrg isfifccfrn ndhpeityrl rndsnfalqt mepalpmppv eeldvmfsel
       61 vdeldltdkh reamfalpae kkwqiycskk kdqeenkgat swpefyidql nsmaarksll
      121 alekeeeeer sktieslkta lrtkpmrfvt rfidldglsc ilnflktmdy etsesrihts
      181 ligcikalmn nsqgrahvla hsesinviaq slsteniktk vavleilgav clvpgghkkv
      241 lqamlhyqky asertrfqtl indldkstgr yrdevslkta imsfinavls qgagvesldf
      301 rlhlryeflm lgiqpvidkl rehenstldr hldffemlrn edelefakrf elvhidtksa
      361 tqmfeltrkr lthseayphf msilhhclqm pykrsgntvq ywllldriiq qiviqndkgq
      421 dpdstplenf niknvvrmlv nenevkqwke qaekmrkehn elqqklekke recdaktqek
      481 eemmqtlnkm keklekette hkqvkqqvad ltaqlhelsr ravcasipgg pspgapggpf
      541 pssvpgsllp pppppplpgg mlpppppplp pggpppppgp pplgaimppp gapmglalkk
      601 ksipqptnal ksfnwsklpe nklegtvwte iddtkvfkil dledlertfs ayqrqqdffv
      661 nsnskqkead aiddtlsskl kvkelsvidg rraqncnill srlklsndei krailtmdeq
      721 edlpkdmleq llkfvpeksd idlleehkhe ldrmakadrf lfemsrinhy qqrlqslyfk
      781 kkfaervaev kpkveairsg seevfrsgal kqllevvlaf gnymnkgqrg naygfkissl
      841 nkiadtkssi dknitllhyl itivenkyps vlnlneelrd ipqaakvnmt eldkeistlr
      901 sglkavetel eyqksqppqp gdkfvsvvsq fitvasfsfs dvedllaeak dlftkavkhf
      961 geeagkiqpd effgifdqfl qavseakqen enmrkkkeee errarmeaql keqrererkm
     1021 rkakensees gefddlvsal rsgevfdkdl sklkrnrkri tnqmtdssre rpitklnf
//
LOCUS       XP_005267488            1078 aa            linear   PRI 05-AUG-2025
DEFINITION  disheveled-associated activator of morphogenesis 1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_005267488
VERSION     XP_005267488.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267431.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1078
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1078
                     /product="disheveled-associated activator of morphogenesis
                     1 isoform X1"
                     /calculated_mol_wt=123343
     Region          45..232
                     /region_name="Drf_GBD"
                     /note="Diaphanous GTPase-binding Domain; pfam06371"
                     /db_xref="CDD:461886"
     Region          235..439
                     /region_name="Drf_FH3"
                     /note="Diaphanous FH3 Domain; pfam06367"
                     /db_xref="CDD:461885"
     Region          444..>513
                     /region_name="PRK12704"
                     /note="phosphodiesterase; Provisional"
                     /db_xref="CDD:237177"
     Region          600..984
                     /region_name="FH2"
                     /note="Formin Homology 2 Domain; pfam02181"
                     /db_xref="CDD:396655"
     CDS             1..1078
                     /gene="DAAM1"
                     /coded_by="XM_005267431.2:286..3522"
                     /db_xref="GeneID:23002"
                     /db_xref="HGNC:HGNC:18142"
                     /db_xref="MIM:606626"
ORIGIN      
        1 maprkrggrg isfifccfrn ndhpeityrl rndsnfalqt mepalpmppv eeldvmfsel
       61 vdeldltdkh reamfalpae kkwqiycskk kdqeenkgat swpefyidql nsmaarksll
      121 alekeeeeer sktieslkta lrtkpmrfvt rfidldglsc ilnflktmdy etsesrihts
      181 ligcikalmn nsqgrahvla hsesinviaq slsteniktk vavleilgav clvpgghkkv
      241 lqamlhyqky asertrfqtl indldkstgr yrdevslkta imsfinavls qgagvesldf
      301 rlhlryeflm lgiqpvidkl rehenstldr hldffemlrn edelefakrf elvhidtksa
      361 tqmfeltrkr lthseayphf msilhhclqm pykrsgntvq ywllldriiq qiviqndkgq
      421 dpdstplenf niknvvrmlv nenevkqwke qaekmrkehn elqqklekke recdaktqek
      481 eemmqtlnkm keklekette hkqvkqqvad ltaqlhelsr ravcasipgg pspgapggpf
      541 pssvpgsllp pppppplpgg mlpppppplp pggpppppgp pplgaimppp gapmglalkk
      601 ksipqptnal ksfnwsklpe nklegtvwte iddtkvfkil dledlertfs ayqrqqdffv
      661 nsnskqkead aiddtlsskl kvkelsvidg rraqncnill srlklsndei krailtmdeq
      721 edlpkdmleq llkfvpeksd idlleehkhe ldrmakadrf lfemsrinhy qqrlqslyfk
      781 kkfaervaev kpkveairsg seevfrsgal kqllevvlaf gnymnkgqrg naygfkissl
      841 nkiadtkssi dknitllhyl itivenkyps vlnlneelrd ipqaakvnmt eldkeistlr
      901 sglkavetel eyqksqppqp gdkfvsvvsq fitvasfsfs dvedllaeak dlftkavkhf
      961 geeagkiqpd effgifdqfl qavseakqen enmrkkkeee errarmeaql keqrererkm
     1021 rkakensees gefddlvsal rsgevfdkdl sklkrnrkri tnqmtdssre rpitklnf
//
LOCUS       XP_047287091            1068 aa            linear   PRI 05-AUG-2025
DEFINITION  disheveled-associated activator of morphogenesis 1 isoform X2 [Homo
            sapiens].
ACCESSION   XP_047287091
VERSION     XP_047287091.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431135.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1068
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1068
                     /product="disheveled-associated activator of morphogenesis
                     1 isoform X2"
                     /calculated_mol_wt=122176
     Region          45..232
                     /region_name="Drf_GBD"
                     /note="Diaphanous GTPase-binding Domain; pfam06371"
                     /db_xref="CDD:461886"
     Region          235..439
                     /region_name="Drf_FH3"
                     /note="Diaphanous FH3 Domain; pfam06367"
                     /db_xref="CDD:461885"
     Region          444..>513
                     /region_name="PRK12704"
                     /note="phosphodiesterase; Provisional"
                     /db_xref="CDD:237177"
     Region          600..974
                     /region_name="FH2"
                     /note="Formin Homology 2 Domain; pfam02181"
                     /db_xref="CDD:396655"
     CDS             1..1068
                     /gene="DAAM1"
                     /coded_by="XM_047431135.1:286..3492"
                     /db_xref="GeneID:23002"
                     /db_xref="HGNC:HGNC:18142"
                     /db_xref="MIM:606626"
ORIGIN      
        1 maprkrggrg isfifccfrn ndhpeityrl rndsnfalqt mepalpmppv eeldvmfsel
       61 vdeldltdkh reamfalpae kkwqiycskk kdqeenkgat swpefyidql nsmaarksll
      121 alekeeeeer sktieslkta lrtkpmrfvt rfidldglsc ilnflktmdy etsesrihts
      181 ligcikalmn nsqgrahvla hsesinviaq slsteniktk vavleilgav clvpgghkkv
      241 lqamlhyqky asertrfqtl indldkstgr yrdevslkta imsfinavls qgagvesldf
      301 rlhlryeflm lgiqpvidkl rehenstldr hldffemlrn edelefakrf elvhidtksa
      361 tqmfeltrkr lthseayphf msilhhclqm pykrsgntvq ywllldriiq qiviqndkgq
      421 dpdstplenf niknvvrmlv nenevkqwke qaekmrkehn elqqklekke recdaktqek
      481 eemmqtlnkm keklekette hkqvkqqvad ltaqlhelsr ravcasipgg pspgapggpf
      541 pssvpgsllp pppppplpgg mlpppppplp pggpppppgp pplgaimppp gapmglalkk
      601 ksipqptnal ksfnwsklpe nklegtvwte iddtkvfkil dledlertfs ayqrqqkead
      661 aiddtlsskl kvkelsvidg rraqncnill srlklsndei krailtmdeq edlpkdmleq
      721 llkfvpeksd idlleehkhe ldrmakadrf lfemsrinhy qqrlqslyfk kkfaervaev
      781 kpkveairsg seevfrsgal kqllevvlaf gnymnkgqrg naygfkissl nkiadtkssi
      841 dknitllhyl itivenkyps vlnlneelrd ipqaakvnmt eldkeistlr sglkavetel
      901 eyqksqppqp gdkfvsvvsq fitvasfsfs dvedllaeak dlftkavkhf geeagkiqpd
      961 effgifdqfl qavseakqen enmrkkkeee errarmeaql keqrererkm rkakensees
     1021 gefddlvsal rsgevfdkdl sklkrnrkri tnqmtdssre rpitklnf
//
LOCUS       XP_047287092             754 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Smaug homolog 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047287092
VERSION     XP_047287092.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431136.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..754
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..754
                     /product="protein Smaug homolog 1 isoform X1"
                     /calculated_mol_wt=82905
     Region          320..382
                     /region_name="SAM_Smaug"
                     /note="SAM domain of Smaug subfamily; cd09557"
                     /db_xref="CDD:188956"
     Site            order(336,338..339,367,370..372,379,381)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:188956"
     CDS             1..754
                     /gene="SAMD4A"
                     /gene_synonym="SAMD4; SMAUG; SMAUG1; SMG; SMGA"
                     /coded_by="XM_047431136.1:624..2888"
                     /db_xref="GeneID:23034"
                     /db_xref="HGNC:HGNC:23023"
                     /db_xref="MIM:610747"
ORIGIN      
        1 mmfrdqvgvl agwfkgwnec eqtvallsll krvsqtqarf lqlclehsla dcaelhvler
       61 eanspgiinq wqqeskdkvi slllthlpll kpgnldakve ymkllpkila hsiehnqhie
      121 esrqllsyal ihpatsledr salamwlnhl edrtstsfgg qnrgrsdsvd ygqthyyhqr
      181 qnsddklngw qnsrdsgici nasnwqdksm gcenghvply ssssvpttin tigtststil
      241 sgqahhsplk rsvsltppmn vpnqplghgw mshedlrarg pqclpsdhap lspqssvass
      301 gsggsehled qttarntfqe egsgmkdvpa wlkslrlhky aalfsqmtye emmaltecql
      361 eaqnvtkgar hkivisiqkl kerqnllksl erdiieggsl riplqelhqm iltpikayss
      421 psttpearrr epqaprqpsl mgpesqspdc kdgaaatgat atpsagasgg lqphqlsscd
      481 gelavaplpe gdlpgqftrv mgkvctqllv srpdeeniss ylqlidkcli heaftetqkk
      541 rllswkqqvq klfrsfprkt lldisgyrqq rnrgfgqsns lptagsvggg mgrrnprqyq
      601 ipsrnvpsar lgllgtsgfv ssnqrnttat ptimkqgrqn lwfanpggsn smpsrthssv
      661 qrtrslpvht spqnmlmfqq pgsqvhsglc ltdlrgwlsl sgapsmpalt vpkssqgefq
      721 lpvtepdinn rleslclsmt ehalgdgvdr tsti
//
LOCUS       XP_024305282             754 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Smaug homolog 1 isoform X1 [Homo sapiens].
ACCESSION   XP_024305282
VERSION     XP_024305282.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449514.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..754
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..754
                     /product="protein Smaug homolog 1 isoform X1"
                     /calculated_mol_wt=82905
     Region          320..382
                     /region_name="SAM_Smaug"
                     /note="SAM domain of Smaug subfamily; cd09557"
                     /db_xref="CDD:188956"
     Site            order(336,338..339,367,370..372,379,381)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:188956"
     CDS             1..754
                     /gene="SAMD4A"
                     /gene_synonym="SAMD4; SMAUG; SMAUG1; SMG; SMGA"
                     /coded_by="XM_024449514.2:605..2869"
                     /db_xref="GeneID:23034"
                     /db_xref="HGNC:HGNC:23023"
                     /db_xref="MIM:610747"
ORIGIN      
        1 mmfrdqvgvl agwfkgwnec eqtvallsll krvsqtqarf lqlclehsla dcaelhvler
       61 eanspgiinq wqqeskdkvi slllthlpll kpgnldakve ymkllpkila hsiehnqhie
      121 esrqllsyal ihpatsledr salamwlnhl edrtstsfgg qnrgrsdsvd ygqthyyhqr
      181 qnsddklngw qnsrdsgici nasnwqdksm gcenghvply ssssvpttin tigtststil
      241 sgqahhsplk rsvsltppmn vpnqplghgw mshedlrarg pqclpsdhap lspqssvass
      301 gsggsehled qttarntfqe egsgmkdvpa wlkslrlhky aalfsqmtye emmaltecql
      361 eaqnvtkgar hkivisiqkl kerqnllksl erdiieggsl riplqelhqm iltpikayss
      421 psttpearrr epqaprqpsl mgpesqspdc kdgaaatgat atpsagasgg lqphqlsscd
      481 gelavaplpe gdlpgqftrv mgkvctqllv srpdeeniss ylqlidkcli heaftetqkk
      541 rllswkqqvq klfrsfprkt lldisgyrqq rnrgfgqsns lptagsvggg mgrrnprqyq
      601 ipsrnvpsar lgllgtsgfv ssnqrnttat ptimkqgrqn lwfanpggsn smpsrthssv
      661 qrtrslpvht spqnmlmfqq pgsqvhsglc ltdlrgwlsl sgapsmpalt vpkssqgefq
      721 lpvtepdinn rleslclsmt ehalgdgvdr tsti
//
LOCUS       XP_024305283             754 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Smaug homolog 1 isoform X1 [Homo sapiens].
ACCESSION   XP_024305283
VERSION     XP_024305283.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449515.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..754
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..754
                     /product="protein Smaug homolog 1 isoform X1"
                     /calculated_mol_wt=82905
     Region          320..382
                     /region_name="SAM_Smaug"
                     /note="SAM domain of Smaug subfamily; cd09557"
                     /db_xref="CDD:188956"
     Site            order(336,338..339,367,370..372,379,381)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:188956"
     CDS             1..754
                     /gene="SAMD4A"
                     /gene_synonym="SAMD4; SMAUG; SMAUG1; SMG; SMGA"
                     /coded_by="XM_024449515.2:633..2897"
                     /db_xref="GeneID:23034"
                     /db_xref="HGNC:HGNC:23023"
                     /db_xref="MIM:610747"
ORIGIN      
        1 mmfrdqvgvl agwfkgwnec eqtvallsll krvsqtqarf lqlclehsla dcaelhvler
       61 eanspgiinq wqqeskdkvi slllthlpll kpgnldakve ymkllpkila hsiehnqhie
      121 esrqllsyal ihpatsledr salamwlnhl edrtstsfgg qnrgrsdsvd ygqthyyhqr
      181 qnsddklngw qnsrdsgici nasnwqdksm gcenghvply ssssvpttin tigtststil
      241 sgqahhsplk rsvsltppmn vpnqplghgw mshedlrarg pqclpsdhap lspqssvass
      301 gsggsehled qttarntfqe egsgmkdvpa wlkslrlhky aalfsqmtye emmaltecql
      361 eaqnvtkgar hkivisiqkl kerqnllksl erdiieggsl riplqelhqm iltpikayss
      421 psttpearrr epqaprqpsl mgpesqspdc kdgaaatgat atpsagasgg lqphqlsscd
      481 gelavaplpe gdlpgqftrv mgkvctqllv srpdeeniss ylqlidkcli heaftetqkk
      541 rllswkqqvq klfrsfprkt lldisgyrqq rnrgfgqsns lptagsvggg mgrrnprqyq
      601 ipsrnvpsar lgllgtsgfv ssnqrnttat ptimkqgrqn lwfanpggsn smpsrthssv
      661 qrtrslpvht spqnmlmfqq pgsqvhsglc ltdlrgwlsl sgapsmpalt vpkssqgefq
      721 lpvtepdinn rleslclsmt ehalgdgvdr tsti
//
LOCUS       XP_047287093             754 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Smaug homolog 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047287093
VERSION     XP_047287093.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431137.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..754
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..754
                     /product="protein Smaug homolog 1 isoform X1"
                     /calculated_mol_wt=82905
     Region          320..382
                     /region_name="SAM_Smaug"
                     /note="SAM domain of Smaug subfamily; cd09557"
                     /db_xref="CDD:188956"
     Site            order(336,338..339,367,370..372,379,381)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:188956"
     CDS             1..754
                     /gene="SAMD4A"
                     /gene_synonym="SAMD4; SMAUG; SMAUG1; SMG; SMGA"
                     /coded_by="XM_047431137.1:965..3229"
                     /db_xref="GeneID:23034"
                     /db_xref="HGNC:HGNC:23023"
                     /db_xref="MIM:610747"
ORIGIN      
        1 mmfrdqvgvl agwfkgwnec eqtvallsll krvsqtqarf lqlclehsla dcaelhvler
       61 eanspgiinq wqqeskdkvi slllthlpll kpgnldakve ymkllpkila hsiehnqhie
      121 esrqllsyal ihpatsledr salamwlnhl edrtstsfgg qnrgrsdsvd ygqthyyhqr
      181 qnsddklngw qnsrdsgici nasnwqdksm gcenghvply ssssvpttin tigtststil
      241 sgqahhsplk rsvsltppmn vpnqplghgw mshedlrarg pqclpsdhap lspqssvass
      301 gsggsehled qttarntfqe egsgmkdvpa wlkslrlhky aalfsqmtye emmaltecql
      361 eaqnvtkgar hkivisiqkl kerqnllksl erdiieggsl riplqelhqm iltpikayss
      421 psttpearrr epqaprqpsl mgpesqspdc kdgaaatgat atpsagasgg lqphqlsscd
      481 gelavaplpe gdlpgqftrv mgkvctqllv srpdeeniss ylqlidkcli heaftetqkk
      541 rllswkqqvq klfrsfprkt lldisgyrqq rnrgfgqsns lptagsvggg mgrrnprqyq
      601 ipsrnvpsar lgllgtsgfv ssnqrnttat ptimkqgrqn lwfanpggsn smpsrthssv
      661 qrtrslpvht spqnmlmfqq pgsqvhsglc ltdlrgwlsl sgapsmpalt vpkssqgefq
      721 lpvtepdinn rleslclsmt ehalgdgvdr tsti
//
LOCUS       XP_024305284             732 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Smaug homolog 1 isoform X2 [Homo sapiens].
ACCESSION   XP_024305284
VERSION     XP_024305284.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449516.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..732
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..732
                     /product="protein Smaug homolog 1 isoform X2"
                     /calculated_mol_wt=80752
     Region          320..382
                     /region_name="SAM_Smaug"
                     /note="SAM domain of Smaug subfamily; cd09557"
                     /db_xref="CDD:188956"
     Site            order(336,338..339,367,370..372,379,381)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:188956"
     CDS             1..732
                     /gene="SAMD4A"
                     /gene_synonym="SAMD4; SMAUG; SMAUG1; SMG; SMGA"
                     /coded_by="XM_024449516.2:624..2822"
                     /db_xref="GeneID:23034"
                     /db_xref="HGNC:HGNC:23023"
                     /db_xref="MIM:610747"
ORIGIN      
        1 mmfrdqvgvl agwfkgwnec eqtvallsll krvsqtqarf lqlclehsla dcaelhvler
       61 eanspgiinq wqqeskdkvi slllthlpll kpgnldakve ymkllpkila hsiehnqhie
      121 esrqllsyal ihpatsledr salamwlnhl edrtstsfgg qnrgrsdsvd ygqthyyhqr
      181 qnsddklngw qnsrdsgici nasnwqdksm gcenghvply ssssvpttin tigtststil
      241 sgqahhsplk rsvsltppmn vpnqplghgw mshedlrarg pqclpsdhap lspqssvass
      301 gsggsehled qttarntfqe egsgmkdvpa wlkslrlhky aalfsqmtye emmaltecql
      361 eaqnvtkgar hkivisiqkl kerqnllksl erdiieggsl riplqelhqm iltpikayss
      421 psttpearrr epqaprqpsl mgpesqspdc kdgaaatgat atpsagasgg lqphqlsscd
      481 gelavaplpe gdlpgqftrv mgkvctqllv srpdeeniss ylqlidkcli heaftetqkk
      541 rllswkqqvq klfrsfprkt lldisgyrqq rnrgfgqsns lptagsvggg mgrrnprqyq
      601 ipsrnvpsar lgllgtsgfv ssnqrnttat ptimkqgrqn lwfanpggsn smpsrthssv
      661 qrtrslpvht spqnmlmfqq pgsqvhsglc ltdlrefqlp vtepdinnrl eslclsmteh
      721 algdgvdrts ti
//
LOCUS       XP_047287094             718 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Smaug homolog 1 isoform X3 [Homo sapiens].
ACCESSION   XP_047287094
VERSION     XP_047287094.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431138.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..718
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..718
                     /product="protein Smaug homolog 1 isoform X3"
                     /calculated_mol_wt=79284
     Region          320..382
                     /region_name="SAM_Smaug"
                     /note="SAM domain of Smaug subfamily; cd09557"
                     /db_xref="CDD:188956"
     Site            order(336,338..339,367,370..372,379,381)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:188956"
     CDS             1..718
                     /gene="SAMD4A"
                     /gene_synonym="SAMD4; SMAUG; SMAUG1; SMG; SMGA"
                     /coded_by="XM_047431138.1:624..2780"
                     /db_xref="GeneID:23034"
                     /db_xref="HGNC:HGNC:23023"
                     /db_xref="MIM:610747"
ORIGIN      
        1 mmfrdqvgvl agwfkgwnec eqtvallsll krvsqtqarf lqlclehsla dcaelhvler
       61 eanspgiinq wqqeskdkvi slllthlpll kpgnldakve ymkllpkila hsiehnqhie
      121 esrqllsyal ihpatsledr salamwlnhl edrtstsfgg qnrgrsdsvd ygqthyyhqr
      181 qnsddklngw qnsrdsgici nasnwqdksm gcenghvply ssssvpttin tigtststil
      241 sgqahhsplk rsvsltppmn vpnqplghgw mshedlrarg pqclpsdhap lspqssvass
      301 gsggsehled qttarntfqe egsgmkdvpa wlkslrlhky aalfsqmtye emmaltecql
      361 eaqnvtkgar hkivisiqkl kerqnllksl erdiieggsl riplqelhqm iltpikayss
      421 psttpearrr epqaprqpsl mgpesqspdc kdgaaatgat atpsagasgg lqphqlsscd
      481 gelavaplpe gdlpgqftrv mgkvctqllv srpdeeniss ylqlidkcli heaftetqkk
      541 rllswkqqvq klfrsfprkt lldisgyrqq rnrgfgqsns lptagsvggg mgrrnprqyq
      601 ipsrnvpsar lgllgtsgfv ssnqrnttat ptimkqgrqn lwfanpggsn smpsrthssv
      661 qrtrslpvht spqnmlmfqq pefqlpvtep dinnrleslc lsmtehalgd gvdrtsti
//
LOCUS       XP_047287095             718 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Smaug homolog 1 isoform X3 [Homo sapiens].
ACCESSION   XP_047287095
VERSION     XP_047287095.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431139.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..718
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..718
                     /product="protein Smaug homolog 1 isoform X3"
                     /calculated_mol_wt=79284
     Region          320..382
                     /region_name="SAM_Smaug"
                     /note="SAM domain of Smaug subfamily; cd09557"
                     /db_xref="CDD:188956"
     Site            order(336,338..339,367,370..372,379,381)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:188956"
     CDS             1..718
                     /gene="SAMD4A"
                     /gene_synonym="SAMD4; SMAUG; SMAUG1; SMG; SMGA"
                     /coded_by="XM_047431139.1:605..2761"
                     /db_xref="GeneID:23034"
                     /db_xref="HGNC:HGNC:23023"
                     /db_xref="MIM:610747"
ORIGIN      
        1 mmfrdqvgvl agwfkgwnec eqtvallsll krvsqtqarf lqlclehsla dcaelhvler
       61 eanspgiinq wqqeskdkvi slllthlpll kpgnldakve ymkllpkila hsiehnqhie
      121 esrqllsyal ihpatsledr salamwlnhl edrtstsfgg qnrgrsdsvd ygqthyyhqr
      181 qnsddklngw qnsrdsgici nasnwqdksm gcenghvply ssssvpttin tigtststil
      241 sgqahhsplk rsvsltppmn vpnqplghgw mshedlrarg pqclpsdhap lspqssvass
      301 gsggsehled qttarntfqe egsgmkdvpa wlkslrlhky aalfsqmtye emmaltecql
      361 eaqnvtkgar hkivisiqkl kerqnllksl erdiieggsl riplqelhqm iltpikayss
      421 psttpearrr epqaprqpsl mgpesqspdc kdgaaatgat atpsagasgg lqphqlsscd
      481 gelavaplpe gdlpgqftrv mgkvctqllv srpdeeniss ylqlidkcli heaftetqkk
      541 rllswkqqvq klfrsfprkt lldisgyrqq rnrgfgqsns lptagsvggg mgrrnprqyq
      601 ipsrnvpsar lgllgtsgfv ssnqrnttat ptimkqgrqn lwfanpggsn smpsrthssv
      661 qrtrslpvht spqnmlmfqq pefqlpvtep dinnrleslc lsmtehalgd gvdrtsti
//
LOCUS       XP_047287096             666 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Smaug homolog 1 isoform X4 [Homo sapiens].
ACCESSION   XP_047287096
VERSION     XP_047287096.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431140.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..666
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..666
                     /product="protein Smaug homolog 1 isoform X4"
                     /calculated_mol_wt=73586
     Region          238..294
                     /region_name="SAM_Smaug"
                     /note="SAM domain of Smaug subfamily; cd09557"
                     /db_xref="CDD:188956"
     Site            order(248,250..251,279,282..284,291,293)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:188956"
     CDS             1..666
                     /gene="SAMD4A"
                     /gene_synonym="SAMD4; SMAUG; SMAUG1; SMG; SMGA"
                     /coded_by="XM_047431140.1:624..2624"
                     /db_xref="GeneID:23034"
                     /db_xref="HGNC:HGNC:23023"
                     /db_xref="MIM:610747"
ORIGIN      
        1 mmfrdqvgvl agwfkgwnec eqtvallsll krvsqtqarf lqlclehsla dcaelhvler
       61 eanspgiinq wqqeskdkvi slllthlpll kpgnldakve ymkllpkila hsiehnqhie
      121 esrqllsyal ihpatsledr salamwlnhl edrtstsfgg qnrgrsdsvd ygqthyyhqr
      181 qnsddklngw qnsrdsgici nasnwqdksm gcenghvply ssssvpttin tigtststnv
      241 pawlkslrlh kyaalfsqmt yeemmaltec qleaqnvtkg arhkivisiq klkerqnllk
      301 slerdiiegg slriplqelh qmiltpikay sspsttpear rrepqaprqp slmgpesqsp
      361 dckdgaaatg atatpsagas gglqphqlss cdgelavapl pegdlpgqft rvmgkvctql
      421 lvsrpdeeni ssylqlidkc liheaftetq kkrllswkqq vqklfrsfpr ktlldisgyr
      481 qqrnrgfgqs nslptagsvg ggmgrrnprq yqipsrnvps arlgllgtsg fvssnqrntt
      541 atptimkqgr qnlwfanpgg snsmpsrths svqrtrslpv htspqnmlmf qqpgsqvhsg
      601 lcltdlrgwl slsgapsmpa ltvpkssqge fqlpvtepdi nnrleslcls mtehalgdgv
      661 drtsti
//
LOCUS       XP_047287097             666 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Smaug homolog 1 isoform X4 [Homo sapiens].
ACCESSION   XP_047287097
VERSION     XP_047287097.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431141.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..666
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..666
                     /product="protein Smaug homolog 1 isoform X4"
                     /calculated_mol_wt=73586
     Region          238..294
                     /region_name="SAM_Smaug"
                     /note="SAM domain of Smaug subfamily; cd09557"
                     /db_xref="CDD:188956"
     Site            order(248,250..251,279,282..284,291,293)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:188956"
     CDS             1..666
                     /gene="SAMD4A"
                     /gene_synonym="SAMD4; SMAUG; SMAUG1; SMG; SMGA"
                     /coded_by="XM_047431141.1:605..2605"
                     /db_xref="GeneID:23034"
                     /db_xref="HGNC:HGNC:23023"
                     /db_xref="MIM:610747"
ORIGIN      
        1 mmfrdqvgvl agwfkgwnec eqtvallsll krvsqtqarf lqlclehsla dcaelhvler
       61 eanspgiinq wqqeskdkvi slllthlpll kpgnldakve ymkllpkila hsiehnqhie
      121 esrqllsyal ihpatsledr salamwlnhl edrtstsfgg qnrgrsdsvd ygqthyyhqr
      181 qnsddklngw qnsrdsgici nasnwqdksm gcenghvply ssssvpttin tigtststnv
      241 pawlkslrlh kyaalfsqmt yeemmaltec qleaqnvtkg arhkivisiq klkerqnllk
      301 slerdiiegg slriplqelh qmiltpikay sspsttpear rrepqaprqp slmgpesqsp
      361 dckdgaaatg atatpsagas gglqphqlss cdgelavapl pegdlpgqft rvmgkvctql
      421 lvsrpdeeni ssylqlidkc liheaftetq kkrllswkqq vqklfrsfpr ktlldisgyr
      481 qqrnrgfgqs nslptagsvg ggmgrrnprq yqipsrnvps arlgllgtsg fvssnqrntt
      541 atptimkqgr qnlwfanpgg snsmpsrths svqrtrslpv htspqnmlmf qqpgsqvhsg
      601 lcltdlrgwl slsgapsmpa ltvpkssqge fqlpvtepdi nnrleslcls mtehalgdgv
      661 drtsti
//
LOCUS       XP_047287098             653 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Smaug homolog 1 isoform X5 [Homo sapiens].
ACCESSION   XP_047287098
VERSION     XP_047287098.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431142.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 14% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..653
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..653
                     /product="protein Smaug homolog 1 isoform X5"
                     /calculated_mol_wt=71420
     Region          219..281
                     /region_name="SAM_Smaug"
                     /note="SAM domain of Smaug subfamily; cd09557"
                     /db_xref="CDD:188956"
     Site            order(235,237..238,266,269..271,278,280)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:188956"
     CDS             1..653
                     /gene="SAMD4A"
                     /gene_synonym="SAMD4; SMAUG; SMAUG1; SMG; SMGA"
                     /coded_by="XM_047431142.1:732..2693"
                     /db_xref="GeneID:23034"
                     /db_xref="HGNC:HGNC:23023"
                     /db_xref="MIM:610747"
ORIGIN      
        1 mkllpkilah siehnqhiee srqllsyali hpatsledrs alamwlnhle drtstsfggq
       61 nrgrsdsvdy gqthyyhqrq nsddklngwq nsrdsgicin asnwqdksmg cenghvplys
      121 sssvpttint igtststils gqahhsplkr svsltppmnv pnqplghgwm shedlrargp
      181 qclpsdhapl spqssvassg sggsehledq ttarntfqee gsgmkdvpaw lkslrlhkya
      241 alfsqmtyee mmaltecqle aqnvtkgarh kivisiqklk erqnllksle rdiieggslr
      301 iplqelhqmi ltpikayssp sttpearrre pqaprqpslm gpesqspdck dgaaatgata
      361 tpsagasggl qphqlsscdg elavaplpeg dlpgqftrvm gkvctqllvs rpdeenissy
      421 lqlidkclih eaftetqkkr llswkqqvqk lfrsfprktl ldisgyrqqr nrgfgqsnsl
      481 ptagsvgggm grrnprqyqi psrnvpsarl gllgtsgfvs snqrnttatp timkqgrqnl
      541 wfanpggsns mpsrthssvq rtrslpvhts pqnmlmfqqp gsqvhsglcl tdlrgwlsls
      601 gapsmpaltv pkssqgefql pvtepdinnr leslclsmte halgdgvdrt sti
//
LOCUS       XP_047287099             644 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Smaug homolog 1 isoform X6 [Homo sapiens].
ACCESSION   XP_047287099
VERSION     XP_047287099.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431143.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..644
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..644
                     /product="protein Smaug homolog 1 isoform X6"
                     /calculated_mol_wt=71432
     Region          238..294
                     /region_name="SAM_Smaug"
                     /note="SAM domain of Smaug subfamily; cd09557"
                     /db_xref="CDD:188956"
     Site            order(248,250..251,279,282..284,291,293)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:188956"
     CDS             1..644
                     /gene="SAMD4A"
                     /gene_synonym="SAMD4; SMAUG; SMAUG1; SMG; SMGA"
                     /coded_by="XM_047431143.1:624..2558"
                     /db_xref="GeneID:23034"
                     /db_xref="HGNC:HGNC:23023"
                     /db_xref="MIM:610747"
ORIGIN      
        1 mmfrdqvgvl agwfkgwnec eqtvallsll krvsqtqarf lqlclehsla dcaelhvler
       61 eanspgiinq wqqeskdkvi slllthlpll kpgnldakve ymkllpkila hsiehnqhie
      121 esrqllsyal ihpatsledr salamwlnhl edrtstsfgg qnrgrsdsvd ygqthyyhqr
      181 qnsddklngw qnsrdsgici nasnwqdksm gcenghvply ssssvpttin tigtststnv
      241 pawlkslrlh kyaalfsqmt yeemmaltec qleaqnvtkg arhkivisiq klkerqnllk
      301 slerdiiegg slriplqelh qmiltpikay sspsttpear rrepqaprqp slmgpesqsp
      361 dckdgaaatg atatpsagas gglqphqlss cdgelavapl pegdlpgqft rvmgkvctql
      421 lvsrpdeeni ssylqlidkc liheaftetq kkrllswkqq vqklfrsfpr ktlldisgyr
      481 qqrnrgfgqs nslptagsvg ggmgrrnprq yqipsrnvps arlgllgtsg fvssnqrntt
      541 atptimkqgr qnlwfanpgg snsmpsrths svqrtrslpv htspqnmlmf qqpgsqvhsg
      601 lcltdlrefq lpvtepdinn rleslclsmt ehalgdgvdr tsti
//
LOCUS       XP_047287100             630 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Smaug homolog 1 isoform X7 [Homo sapiens].
ACCESSION   XP_047287100
VERSION     XP_047287100.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431144.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..630
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..630
                     /product="protein Smaug homolog 1 isoform X7"
                     /calculated_mol_wt=69965
     Region          238..294
                     /region_name="SAM_Smaug"
                     /note="SAM domain of Smaug subfamily; cd09557"
                     /db_xref="CDD:188956"
     Site            order(248,250..251,279,282..284,291,293)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:188956"
     CDS             1..630
                     /gene="SAMD4A"
                     /gene_synonym="SAMD4; SMAUG; SMAUG1; SMG; SMGA"
                     /coded_by="XM_047431144.1:624..2516"
                     /db_xref="GeneID:23034"
                     /db_xref="HGNC:HGNC:23023"
                     /db_xref="MIM:610747"
ORIGIN      
        1 mmfrdqvgvl agwfkgwnec eqtvallsll krvsqtqarf lqlclehsla dcaelhvler
       61 eanspgiinq wqqeskdkvi slllthlpll kpgnldakve ymkllpkila hsiehnqhie
      121 esrqllsyal ihpatsledr salamwlnhl edrtstsfgg qnrgrsdsvd ygqthyyhqr
      181 qnsddklngw qnsrdsgici nasnwqdksm gcenghvply ssssvpttin tigtststnv
      241 pawlkslrlh kyaalfsqmt yeemmaltec qleaqnvtkg arhkivisiq klkerqnllk
      301 slerdiiegg slriplqelh qmiltpikay sspsttpear rrepqaprqp slmgpesqsp
      361 dckdgaaatg atatpsagas gglqphqlss cdgelavapl pegdlpgqft rvmgkvctql
      421 lvsrpdeeni ssylqlidkc liheaftetq kkrllswkqq vqklfrsfpr ktlldisgyr
      481 qqrnrgfgqs nslptagsvg ggmgrrnprq yqipsrnvps arlgllgtsg fvssnqrntt
      541 atptimkqgr qnlwfanpgg snsmpsrths svqrtrslpv htspqnmlmf qqpefqlpvt
      601 epdinnrles lclsmtehal gdgvdrtsti
//
LOCUS       XP_047287101             630 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Smaug homolog 1 isoform X7 [Homo sapiens].
ACCESSION   XP_047287101
VERSION     XP_047287101.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431145.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..630
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..630
                     /product="protein Smaug homolog 1 isoform X7"
                     /calculated_mol_wt=69965
     Region          238..294
                     /region_name="SAM_Smaug"
                     /note="SAM domain of Smaug subfamily; cd09557"
                     /db_xref="CDD:188956"
     Site            order(248,250..251,279,282..284,291,293)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:188956"
     CDS             1..630
                     /gene="SAMD4A"
                     /gene_synonym="SAMD4; SMAUG; SMAUG1; SMG; SMGA"
                     /coded_by="XM_047431145.1:605..2497"
                     /db_xref="GeneID:23034"
                     /db_xref="HGNC:HGNC:23023"
                     /db_xref="MIM:610747"
ORIGIN      
        1 mmfrdqvgvl agwfkgwnec eqtvallsll krvsqtqarf lqlclehsla dcaelhvler
       61 eanspgiinq wqqeskdkvi slllthlpll kpgnldakve ymkllpkila hsiehnqhie
      121 esrqllsyal ihpatsledr salamwlnhl edrtstsfgg qnrgrsdsvd ygqthyyhqr
      181 qnsddklngw qnsrdsgici nasnwqdksm gcenghvply ssssvpttin tigtststnv
      241 pawlkslrlh kyaalfsqmt yeemmaltec qleaqnvtkg arhkivisiq klkerqnllk
      301 slerdiiegg slriplqelh qmiltpikay sspsttpear rrepqaprqp slmgpesqsp
      361 dckdgaaatg atatpsagas gglqphqlss cdgelavapl pegdlpgqft rvmgkvctql
      421 lvsrpdeeni ssylqlidkc liheaftetq kkrllswkqq vqklfrsfpr ktlldisgyr
      481 qqrnrgfgqs nslptagsvg ggmgrrnprq yqipsrnvps arlgllgtsg fvssnqrntt
      541 atptimkqgr qnlwfanpgg snsmpsrths svqrtrslpv htspqnmlmf qqpefqlpvt
      601 epdinnrles lclsmtehal gdgvdrtsti
//
LOCUS       XP_047287102             630 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Smaug homolog 1 isoform X7 [Homo sapiens].
ACCESSION   XP_047287102
VERSION     XP_047287102.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431146.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..630
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..630
                     /product="protein Smaug homolog 1 isoform X7"
                     /calculated_mol_wt=69965
     Region          238..294
                     /region_name="SAM_Smaug"
                     /note="SAM domain of Smaug subfamily; cd09557"
                     /db_xref="CDD:188956"
     Site            order(248,250..251,279,282..284,291,293)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:188956"
     CDS             1..630
                     /gene="SAMD4A"
                     /gene_synonym="SAMD4; SMAUG; SMAUG1; SMG; SMGA"
                     /coded_by="XM_047431146.1:633..2525"
                     /db_xref="GeneID:23034"
                     /db_xref="HGNC:HGNC:23023"
                     /db_xref="MIM:610747"
ORIGIN      
        1 mmfrdqvgvl agwfkgwnec eqtvallsll krvsqtqarf lqlclehsla dcaelhvler
       61 eanspgiinq wqqeskdkvi slllthlpll kpgnldakve ymkllpkila hsiehnqhie
      121 esrqllsyal ihpatsledr salamwlnhl edrtstsfgg qnrgrsdsvd ygqthyyhqr
      181 qnsddklngw qnsrdsgici nasnwqdksm gcenghvply ssssvpttin tigtststnv
      241 pawlkslrlh kyaalfsqmt yeemmaltec qleaqnvtkg arhkivisiq klkerqnllk
      301 slerdiiegg slriplqelh qmiltpikay sspsttpear rrepqaprqp slmgpesqsp
      361 dckdgaaatg atatpsagas gglqphqlss cdgelavapl pegdlpgqft rvmgkvctql
      421 lvsrpdeeni ssylqlidkc liheaftetq kkrllswkqq vqklfrsfpr ktlldisgyr
      481 qqrnrgfgqs nslptagsvg ggmgrrnprq yqipsrnvps arlgllgtsg fvssnqrntt
      541 atptimkqgr qnlwfanpgg snsmpsrths svqrtrslpv htspqnmlmf qqpefqlpvt
      601 epdinnrles lclsmtehal gdgvdrtsti
//
LOCUS       XP_016876587            1743 aa            linear   PRI 05-AUG-2025
DEFINITION  TOG array regulator of axonemal microtubules protein 1 isoform X1
            [Homo sapiens].
ACCESSION   XP_016876587
VERSION     XP_016876587.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021098.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1743
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1743
                     /product="TOG array regulator of axonemal microtubules
                     protein 1 isoform X1"
                     /calculated_mol_wt=192034
     Site            order(369..370,373,376,378,412..413,416,419..420,423,
                     453..454,457,460..461,464,488..489,497,500..501,528..529,
                     532,535..536)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          395..423
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          435..465
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          470..501
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          512..537
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     CDS             1..1743
                     /gene="TOGARAM1"
                     /gene_synonym="FAM179B; JBTS37; KIAA0423"
                     /coded_by="XM_017021098.2:233..5464"
                     /db_xref="GeneID:23116"
                     /db_xref="HGNC:HGNC:19959"
                     /db_xref="MIM:617618"
ORIGIN      
        1 maaapsalll lppfpvlsty rlqsrsrpsa petddsrvgg imrgeknyyf rgaagdhgsc
       61 ptttsplasa llmpseavss swsesgggls ggdeedtrll qllrtardps eafqalqaal
      121 prrggrlgfp rrkealyral grvlveggsd ekrlclqlls dvlrgqgeag qleeafslal
      181 lpqlvvslre enpalrkdal qilhiclkrs pgevlrtliq qglestdarl rastalllpi
      241 llttedlllg ldlteviisl arklgdqete eesetafsal qqigerlgqd rfqsyisrlp
      301 salrrhynrr lesqfgsqvp yyleleasgf pedplpcavt lsnsnlkfgi ipqelhsrll
      361 dqedyknrtq aveelkqvlg kfnpsstphs slvgfislly nllddsnfkv vhgtlevlhl
      421 lvirlgeqvq qflgpviaas vkvladnklv ikqeymkifl klmkevgpqq vlclllehlk
      481 hkhsrvreev vnicicsllt ypsedfdlpk lsfdlapalv dskrrvrqaa leafavlass
      541 mgsgktsilf kavdtvelqd ngdgvmnavq arlarktlpr lteqgfveya vlmpssaggr
      601 snhlahgadt dwllagnrtq sahchcgdhv rdsmhiygsy sptictrrvl sagkgknklp
      661 weneqpgimg enqtstskdi eqfstydfip saklklsqgm pvnddlcfsr krvsrnlfqn
      721 srdfnpdclp lcaagttgth qtnlsgkcaq lgfsqicgkt gsvgsdlqfl gttsshqekv
      781 yaslnfgskt qqtfgsqtec tssngqnpsp gayilpsypv ssprtspkht spliispkks
      841 qdnsvnfsns wplksfegls kpspqkklvs qkssdptgrn hgensqekpp vqltpalvrs
      901 pssrrglngt kpvppiprgi sllpdkadls tvghkkkepd diwkcekdsl pidlselnfk
      961 dkdldqeemh sslrslrnsa akkraklsgs tsdlespdsa mkldltmdsp slssspnins
     1021 ysesgvysqe sltsslsttp qgkrimsdif ptfgskpcpt rlssakkkis hiaeqspsag
     1081 vfgslssapa tcsqsvissv engdtfsikq sieppsgiyg rsvqqnissy ldvenekdak
     1141 vsiskstynk mrqkrkeeke lfhnkdcekk eknswermrh tgtekmases etptgaisqy
     1201 kermpsvths peimdlselr pfskpeialt ealrlladed wekkieglnf irclaafhse
     1261 ilntklhetn favvqevknl rsgvsraavv clsdlftylk ksmdqeldtt vkvllhkage
     1321 sntfiredvd kalramvnnv tparavvsli nggqshlhia vrrctaqhls dvlefmeper
     1381 ilsaakdmae rilpaaakfa qdssqetryy grkmlffmmc hpnfekmlek yvpskdlpyi
     1441 kdsvrnlqqk glgeipldtp sakgrrshtg svgntrsssv srdafnsaer avtevrevtr
     1501 ksvprnsles aeylklitgl lnakdfrdri ngikqllsdt ennqdlvvgn ivkifdafks
     1561 rlhdsnskvn lvaletmhkm ipllrdhlsp iinmlipaiv dnnlnsknpg iyaaatnvvq
     1621 alsqhvdnyl llqpfctkaq flngkakqdm tekladivte lyqrkphate qkvlvvlwhl
     1681 lgnmtnsgsl pgaggnirta taklskalfa qmgqnllnqa asqpphikks leelldmtil
     1741 nel
//
LOCUS       XP_016876588            1671 aa            linear   PRI 05-AUG-2025
DEFINITION  TOG array regulator of axonemal microtubules protein 1 isoform X2
            [Homo sapiens].
ACCESSION   XP_016876588
VERSION     XP_016876588.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021099.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1671
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1671
                     /product="TOG array regulator of axonemal microtubules
                     protein 1 isoform X2"
                     /calculated_mol_wt=184153
     Site            order(369..370,373,376,378,412..413,416,419..420,423,
                     453..454,457,460..461,464,488..489,497,500..501,528..529,
                     532,535..536)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          395..423
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          435..465
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          470..501
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          512..537
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     CDS             1..1671
                     /gene="TOGARAM1"
                     /gene_synonym="FAM179B; JBTS37; KIAA0423"
                     /coded_by="XM_017021099.2:233..5248"
                     /db_xref="GeneID:23116"
                     /db_xref="HGNC:HGNC:19959"
                     /db_xref="MIM:617618"
ORIGIN      
        1 maaapsalll lppfpvlsty rlqsrsrpsa petddsrvgg imrgeknyyf rgaagdhgsc
       61 ptttsplasa llmpseavss swsesgggls ggdeedtrll qllrtardps eafqalqaal
      121 prrggrlgfp rrkealyral grvlveggsd ekrlclqlls dvlrgqgeag qleeafslal
      181 lpqlvvslre enpalrkdal qilhiclkrs pgevlrtliq qglestdarl rastalllpi
      241 llttedlllg ldlteviisl arklgdqete eesetafsal qqigerlgqd rfqsyisrlp
      301 salrrhynrr lesqfgsqvp yyleleasgf pedplpcavt lsnsnlkfgi ipqelhsrll
      361 dqedyknrtq aveelkqvlg kfnpsstphs slvgfislly nllddsnfkv vhgtlevlhl
      421 lvirlgeqvq qflgpviaas vkvladnklv ikqeymkifl klmkevgpqq vlclllehlk
      481 hkhsrvreev vnicicsllt ypsedfdlpk lsfdlapalv dskrrvrqaa leafavlass
      541 mgsgktsilf kavdtvelqd ngdgvmnavq arlarktlpr lteqgfveya vlmpssaggr
      601 snhlahgadt dwllagnrtq sahchcgdhv rdsmhiygsy sptictrrvl sagkgknklp
      661 weneqpgimg enqtstskdi eqfstydfip saklklsqgm pvnddlcfsr krvsrnlfqn
      721 srdfnpdclp lcaagttgth qtnlsgkcaq lgfsqicgkt gsvgsdlqfl gttsshqekg
      781 ensqekppvq ltpalvrsps srrglngtkp vppiprgisl lpdkadlstv ghkkkepddi
      841 wkcekdslpi dlselnfkdk dldqeemhss lrslrnsaak kraklsgsts dlespdsamk
      901 ldltmdspsl ssspninsys esgvysqesl tsslsttpqg krimsdifpt fgskpcptrl
      961 ssakkkishi aeqspsagss snpqqissfd ftttkalsed svvvvgkgvf gslssapatc
     1021 sqsvissven gdtfsikqsi eppsgiygrs vqqnissyld venekdakvs iskstynkmr
     1081 qkrkeekelf hnkdcekkek nswermrhtg tekmaseset ptgaisqyke rmpsvthspe
     1141 imdlselrpf skpeialtea lrlladedwe kkieglnfir claafhseil ntklhetnfa
     1201 vvqevknlrs gvsraavvcl sdlftylkks mdqeldttvk vllhkagesn tfiredvdka
     1261 lramvnnvtp aravvsling gqshlhiavr rctaqhlsdv lefmeperil saakdmaeri
     1321 lpaaakfaqd ssqetryygr kmlffmmchp nfekmlekyv pskdlpyikd svrnlqqkgl
     1381 geipldtpsa kgrrshtgsv gntrsssvsr dafnsaerav tevrevtrks vprnslesae
     1441 ylklitglln akdfrdring ikqllsdten nqdlvvgniv kifdafksrl hdsnskvnlv
     1501 aletmhkmip llrdhlspii nmlipaivdn nlnsknpgiy aaatnvvqal sqhvdnylll
     1561 qpfctkaqfl ngkakqdmte kladivtely qrkphateqk vlvvlwhllg nmtnsgslpg
     1621 aggnirtata klskalfaqm gqnllnqaas qpphikksle elldmtilne l
//
LOCUS       XP_011534873            1670 aa            linear   PRI 05-AUG-2025
DEFINITION  TOG array regulator of axonemal microtubules protein 1 isoform X3
            [Homo sapiens].
ACCESSION   XP_011534873
VERSION     XP_011534873.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536571.2
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 22% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1670
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1670
                     /product="TOG array regulator of axonemal microtubules
                     protein 1 isoform X3"
                     /calculated_mol_wt=183957
     Site            order(369..370,373,376,378,412..413,416,419..420,423,
                     453..454,457,460..461,464,488..489,497,500..501,528..529,
                     532,535..536)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          395..423
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          435..465
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          470..501
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          512..537
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     CDS             1..1670
                     /gene="TOGARAM1"
                     /gene_synonym="FAM179B; JBTS37; KIAA0423"
                     /coded_by="XM_011536571.2:233..5245"
                     /db_xref="GeneID:23116"
                     /db_xref="HGNC:HGNC:19959"
                     /db_xref="MIM:617618"
ORIGIN      
        1 maaapsalll lppfpvlsty rlqsrsrpsa petddsrvgg imrgeknyyf rgaagdhgsc
       61 ptttsplasa llmpseavss swsesgggls ggdeedtrll qllrtardps eafqalqaal
      121 prrggrlgfp rrkealyral grvlveggsd ekrlclqlls dvlrgqgeag qleeafslal
      181 lpqlvvslre enpalrkdal qilhiclkrs pgevlrtliq qglestdarl rastalllpi
      241 llttedlllg ldlteviisl arklgdqete eesetafsal qqigerlgqd rfqsyisrlp
      301 salrrhynrr lesqfgsqvp yyleleasgf pedplpcavt lsnsnlkfgi ipqelhsrll
      361 dqedyknrtq aveelkqvlg kfnpsstphs slvgfislly nllddsnfkv vhgtlevlhl
      421 lvirlgeqvq qflgpviaas vkvladnklv ikqeymkifl klmkevgpqq vlclllehlk
      481 hkhsrvreev vnicicsllt ypsedfdlpk lsfdlapalv dskrrvrqaa leafavlass
      541 mgsgktsilf kavdtvelqd ngdgvmnavq arlarktlpr lteqgfveya vlmpssaggr
      601 snhlahgadt dwllagnrtq sahchcgdhv rdsmhiygsy sptictrrvl sagkgknklp
      661 weneqpgimg enqtstskdi eqfstydfip saklklsqgm pvnddlcfsr krvsrnlfqn
      721 srdfnpdclp lcaagttgth qtnlsgkcaq lgfsqicgkt gsvgsdlqfl gttsshqekv
      781 yaslnfgskt qqtfgsqtec tssngqnpsp gayilpsypv ssprtspkht spliispkks
      841 qdnsvnfsns wplksfegls kpspqkklvs qkssdptgrn hgensqekpp vqltpalvrs
      901 pssrrglngt kpvppiprgi sllpdkadls tvghkkkepd diwkcekdsl pidlselnfk
      961 dkdldqeemh sslrslrnsa akkraklsgs tsdlespdsa mkldltmdsp slssspnins
     1021 ysesgvysqe sltsslsttp qgkrimsdif ptfgskpcpt rlssakkkis hiaeqspsag
     1081 sssnpqqiss fdftttkals edsvvvvgkg vfgslssapa tcsqsvissv engdtfsikq
     1141 sieppsgiyg rsvqqnissy ldvenekdak vsiskstynk mrqkrkeeke lfhnkdcekk
     1201 eknswermrh tgtekmases etptgaisqy kermpsvths peimdlselr pfskpeialt
     1261 ealrlladed wekkieglnf irclaafhse ilntklhetn favvqevknl rsgvsraavv
     1321 clsdlftylk ksmdqeldtt vkvllhkage sntfiredvd kalramvnnv tparavvsli
     1381 nggqshlhia vrrctaqhls dvlefmeper ilsaakdmae rilpaaakfa qdssqetryy
     1441 grkmlffmmc hpnfekmlek yvpskdlpyi kdsvrnlqqk glgeipldtp sakgrrshtg
     1501 svgntrsssv srdafnsaer avtevrevtr ksvprnsles aeylklitgl lnakdfrdri
     1561 ngikqllsdt ennqdlvvgn ivkifdafks rlhdsnskvn lvaletmhkm ipllrdhlsp
     1621 iinmlipaiv dnnlnsknpg iyaaatnvvq alsqhtityf yshfaqklsf
//
LOCUS       XP_047287103            1438 aa            linear   PRI 05-AUG-2025
DEFINITION  TOG array regulator of axonemal microtubules protein 1 isoform X4
            [Homo sapiens].
ACCESSION   XP_047287103
VERSION     XP_047287103.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431147.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1438
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1438
                     /product="TOG array regulator of axonemal microtubules
                     protein 1 isoform X4"
                     /calculated_mol_wt=157759
     Site            order(369..370,373,376,378,412..413,416,419..420,423,
                     453..454,457,460..461,464,488..489,497,500..501,528..529,
                     532,535..536)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          395..423
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          435..465
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          470..501
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          512..537
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     CDS             1..1438
                     /gene="TOGARAM1"
                     /gene_synonym="FAM179B; JBTS37; KIAA0423"
                     /coded_by="XM_047431147.1:233..4549"
                     /db_xref="GeneID:23116"
                     /db_xref="HGNC:HGNC:19959"
                     /db_xref="MIM:617618"
ORIGIN      
        1 maaapsalll lppfpvlsty rlqsrsrpsa petddsrvgg imrgeknyyf rgaagdhgsc
       61 ptttsplasa llmpseavss swsesgggls ggdeedtrll qllrtardps eafqalqaal
      121 prrggrlgfp rrkealyral grvlveggsd ekrlclqlls dvlrgqgeag qleeafslal
      181 lpqlvvslre enpalrkdal qilhiclkrs pgevlrtliq qglestdarl rastalllpi
      241 llttedlllg ldlteviisl arklgdqete eesetafsal qqigerlgqd rfqsyisrlp
      301 salrrhynrr lesqfgsqvp yyleleasgf pedplpcavt lsnsnlkfgi ipqelhsrll
      361 dqedyknrtq aveelkqvlg kfnpsstphs slvgfislly nllddsnfkv vhgtlevlhl
      421 lvirlgeqvq qflgpviaas vkvladnklv ikqeymkifl klmkevgpqq vlclllehlk
      481 hkhsrvreev vnicicsllt ypsedfdlpk lsfdlapalv dskrrvrqaa leafavlass
      541 mgsgktsilf kavdtvelqd ngdgvmnavq arlarktlpr lteqgfveya vlmpssaggr
      601 snhlahgadt dwllagnrtq sahchcgdhv rdsmhiygsy sptictrrvl sagkgknklp
      661 weneqpgimg enqtstskdi eqfstydfip saklklsqgm pvnddlcfsr krvsrnlfqn
      721 srdfnpdclp lcaagttgth qtnlsgkcaq lgfsqicgkt gsvgsdlqfl gttsshqekv
      781 yaslnfgskt qqtfgsqtec tssngqnpsp gayilpsypv ssprtspkht spliispkks
      841 qdnsvnfsns wplksfegls kpspqkklvs qkssdptgrn hgensqekpp vqltpalvrs
      901 pssrrglngt kpvppiprgi sllpdkadls tvghkkkepd diwkcekdsl pidlselnfk
      961 dkdldqeemh sslrslrnsa akkraklsgs tsdlespdsa mkldltmdsp slssspnins
     1021 ysesgvysqe sltsslsttp qgkrimsdif ptfgskpcpt rlssakkkis hiaeqspsag
     1081 sssnpqqiss fdftttkals edsvvvvgkg vfgslssapa tcsqsvissv engdtfsikq
     1141 sieppsgiyg rsvqqnissy ldvenekdak vsiskstynk mrqkrkeeke lfhnkdcekk
     1201 eknswermrh tgtekmases etptgaisqy kermpsvths peimdlselr pfskpeialt
     1261 ealrlladed wekkieglnf irclaafhse ilntklhetn favvqevknl rsgvsraavv
     1321 clsdlftylk ksmdqeldtt vkvllhkage sntfiredvd kalramvnnv tparavvsli
     1381 nggqshlhia vrrctaqhls dvlefmeper ilsaakdmae rilpaaakfa qdssqetr
//
LOCUS       XP_016876589             995 aa            linear   PRI 05-AUG-2025
DEFINITION  TOG array regulator of axonemal microtubules protein 1 isoform X5
            [Homo sapiens].
ACCESSION   XP_016876589
VERSION     XP_016876589.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021100.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..995
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..995
                     /product="TOG array regulator of axonemal microtubules
                     protein 1 isoform X5"
                     /calculated_mol_wt=109310
     Site            order(369..370,373,376,378,412..413,416,419..420,423,
                     453..454,457,460..461,464,488..489,497,500..501,528..529,
                     532,535..536)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          395..423
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          435..465
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          470..501
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          512..537
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     CDS             1..995
                     /gene="TOGARAM1"
                     /gene_synonym="FAM179B; JBTS37; KIAA0423"
                     /coded_by="XM_017021100.2:233..3220"
                     /db_xref="GeneID:23116"
                     /db_xref="HGNC:HGNC:19959"
                     /db_xref="MIM:617618"
ORIGIN      
        1 maaapsalll lppfpvlsty rlqsrsrpsa petddsrvgg imrgeknyyf rgaagdhgsc
       61 ptttsplasa llmpseavss swsesgggls ggdeedtrll qllrtardps eafqalqaal
      121 prrggrlgfp rrkealyral grvlveggsd ekrlclqlls dvlrgqgeag qleeafslal
      181 lpqlvvslre enpalrkdal qilhiclkrs pgevlrtliq qglestdarl rastalllpi
      241 llttedlllg ldlteviisl arklgdqete eesetafsal qqigerlgqd rfqsyisrlp
      301 salrrhynrr lesqfgsqvp yyleleasgf pedplpcavt lsnsnlkfgi ipqelhsrll
      361 dqedyknrtq aveelkqvlg kfnpsstphs slvgfislly nllddsnfkv vhgtlevlhl
      421 lvirlgeqvq qflgpviaas vkvladnklv ikqeymkifl klmkevgpqq vlclllehlk
      481 hkhsrvreev vnicicsllt ypsedfdlpk lsfdlapalv dskrrvrqaa leafavlass
      541 mgsgktsilf kavdtvelqd ngdgvmnavq arlarktlpr lteqgfveya vlmpssaggr
      601 snhlahgadt dwllagnrtq sahchcgdhv rdsmhiygsy sptictrrvl sagkgknklp
      661 weneqpgimg enqtstskdi eqfstydfip saklklsqgm pvnddlcfsr krvsrnlfqn
      721 srdfnpdclp lcaagttgth qtnlsgkcaq lgfsqicgkt gsvgsdlqfl gttsshqekv
      781 yaslnfgskt qqtfgsqtec tssngqnpsp gayilpsypv ssprtspkht spliispkks
      841 qdnsvnfsns wplksfegls kpspqkklvs qkssdptgrn hgensqekpp vqltpalvrs
      901 pssrrglngt kpvppiprgi sllpdkadls tvghkkkepd diwkcekdsl pidlselnfk
      961 dkdldqeevr hisniwvktl snktffckek nfsyc
//
LOCUS       XP_047287104             391 aa            linear   PRI 05-AUG-2025
DEFINITION  REST corepressor 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047287104
VERSION     XP_047287104.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431148.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..391
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..391
                     /product="REST corepressor 1 isoform X1"
                     /calculated_mol_wt=42336
     Region          105..158
                     /region_name="ELM2"
                     /note="ELM2 domain; pfam01448"
                     /db_xref="CDD:460214"
     Region          194..238
                     /region_name="SANT"
                     /note="'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains.
                     Tandem copies of the domain bind telomeric DNA tandem
                     repeatsas part of the capping complex. Binding is sequence
                     dependent for repeats which contain the G/C rich motif
                     [C2-3 A (CA)1-6]. The domain is...; cl21498"
                     /db_xref="CDD:473887"
     Site            order(195,224..225,227..228,230..232,234..236)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212559"
     CDS             1..391
                     /gene="RCOR1"
                     /gene_synonym="COREST; RCOR"
                     /coded_by="XM_047431148.1:239..1414"
                     /db_xref="GeneID:23186"
                     /db_xref="HGNC:HGNC:17441"
                     /db_xref="MIM:607675"
ORIGIN      
        1 mpamvekgpe vsgkrrgrnn aaasasaaaa saaasaacas paataasgaa assasaaaas
       61 aaaapnngqn kslaaaapng nsssnsweeg ssgsssdeeh ggggmrvgpq yqavvpdfdp
      121 aklarrsqer dnlgmlvwsp nqnlseakld eyiaiakekh gynmeqalgm lfwhkhniek
      181 sladlpnftp fpdewtvedk vlfeqafsfh gktfhriqqm lpdksiaslv kfyyswkktr
      241 tktsvmdrha rkqkrerees edeleeangn npidievdqn keskkevppt etvpqvkkek
      301 hstqaknrak rkppkgmfls qedveavsan ataattvlrq ldmelvsvkr qiqnikqtns
      361 alkekldggi epyrlpepsg nmaeifrqsq t
//
LOCUS       XP_011534876            6936 aa            linear   PRI 05-AUG-2025
DEFINITION  nesprin-2 isoform X1 [Homo sapiens].
ACCESSION   XP_011534876
VERSION     XP_011534876.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536574.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..6936
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..6936
                     /product="nesprin-2 isoform X1"
                     /calculated_mol_wt=802067
     Region          28..138
                     /region_name="CH_SYNE2_rpt1"
                     /note="first calponin homology (CH) domain found in
                     synaptic nuclear envelope protein 2; cd21242"
                     /db_xref="CDD:409091"
     Site            order(33,37,89,91..92,95..96,98,107..115,120,122..123,
                     125..126,129..130,133)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409091"
     Region          178..286
                     /region_name="CH_SYNE2_rpt2"
                     /note="second calponin homology (CH) domain found in
                     synaptic nuclear envelope protein 2 (SYNE-2) and similar
                     proteins; cd21244"
                     /db_xref="CDD:409093"
     Site            order(183,187,237,239..240,243..244,246,255..263,270,
                     272..273,275..276,279..280,283)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409093"
     Region          <1418..2014
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          <1868..>2369
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          <2338..2712
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          2805..>3389
                     /region_name="CCDC158"
                     /note="Coiled-coil domain-containing protein 158;
                     pfam15921"
                     /db_xref="CDD:464943"
     Region          <3656..>3950
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <3811..4113
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <4496..5321
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          4945..5169
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            5054..5059
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5063..5276
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Region          5123..>5875
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Site            5168..5173
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5178..5384
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cl02488"
                     /db_xref="CDD:413338"
     Site            5275..5280
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5919..6133
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6020..6025
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          6137..6350
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6243..6248
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          6590..6813
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6696..6701
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          <6905..6936
                     /region_name="KASH"
                     /note="Nuclear envelope localization domain; pfam10541"
                     /db_xref="CDD:463142"
     CDS             1..6936
                     /gene="SYNE2"
                     /gene_synonym="EDMD5; KASH2; Nesp2; Nesprin-2; NUA;
                     NUANCE; SYNE-2; TROPH"
                     /coded_by="XM_011536574.2:192..21002"
                     /db_xref="GeneID:23224"
                     /db_xref="HGNC:HGNC:17084"
                     /db_xref="MIM:608442"
ORIGIN      
        1 masspelpte deqgswgidd lhislqaeqe dtqkkaftcw insqlarhts psvisdlftd
       61 ikkghvlldl levlsgqqlp rdkgsntfqc riniehaltf lrnrsiklin ihvtdiidgn
      121 psiilgliwt iilhfhiekl aqtlscnynq pslddvsvvd sspassppak kcskvqarwq
      181 msarkalllw aqeqcatyes vnvtdfkssw rngmaflaii halrpdlidm ksvkhrsnkd
      241 nlreafriae qelkiprlle pedvdvvdpd eksimtyvaq flqyskdapg tgeeaqgkvk
      301 damgwltlqk eklqkllkds endtyfkkyn sllsfmesfn eekksfldvl sikrdldeld
      361 kdhlqlreaw dgldhqinaw kiklnyalpp plhqteawlq eveelmdedl sasqdhsqav
      421 tliqekmtlf kslmdrfehh snilltfenk denhlplvpp nkleemkrri nnilekkfil
      481 llefhyykcl vlglvdevks kldiwnikyg sresvellle dwhkfieeke flarldtsfq
      541 kcgeiyknla gecqninkqy mmvksdvcmy rkniynvkst lqkvlacwat yvenlrllra
      601 cfeetkkeei kevpfetlaq wnlehatlne agnflvevsn dvvgssiske lrrlnkrwrk
      661 lvsktqlemn lplmikkqdq ptfdnsgnil skeekatvef stdmsvelpe nynqnikage
      721 khekeneeft gqlkvakdve kligqveiwe aeaksvldqd dvdtsmeesl khliakgsmf
      781 delmarsedm lqmdiqniss qesfqhvltt glqakiqeak ekvqinvvkl iaalknltdv
      841 spdldirlkm eesqkelesy mmraqqllgq respgelisk hkealiisnt kslakylkav
      901 eelknnvted ikmsleeksr dvcakweslh helslyvqql kidiekgkls dnilklekqi
      961 nkekklirrg rtkglikehe acfseegcly qlnhhmevlr elceelpsqk sqqevkrllk
     1021 dyeqkierll kcaseihmtl qptaggtskn egtittsenr ggdphseapf aksdnqpste
     1081 kameptmkfs lasvlrplqe esimekdysa sinslleryd tyrdilehhl qnnkfritsd
     1141 fsseedrsss clqakltdlq viknetdarw kefeiislkl enhvndikkp fvikerdtlk
     1201 ererelqmtl ntrmesleta lrlvlpveka slllcgsdlp lhkmaiqgfh lidadriyqh
     1261 lrniqdsiak qieicnrlee pgnfvlkelh pfdlhamqni ilkyktqfeg mnhrvqrsed
     1321 tlkaledfla slrtaklsae pvtdlsasdt qvaqentltv knkegeihlm kdkakhldkc
     1381 lkmldmsfkd aergddtsce nlldafsikl sethgygvqe efteenklle acifknnell
     1441 kniqdvqsqi skiglkdptv pavkhrkksl irldkvldey eeekrhlqem anslphfkdg
     1501 rektvnqqcq ntvvlwentk alvtecleqc grvlellkqy qnfksilttl iqkeesvisl
     1561 qasymgkenl kkriaeieiv keefnehlev vdkinqvckn lqfylnkmkt feeppfekea
     1621 niivdrwldi nektedyyen lgralalwdk lfnlknvide wtekalqkme lhqlteedre
     1681 rlkeelqvhe qktsefsrrv aeiqfllqss eiplelqvme ssilnkmehv qkcltgesnc
     1741 halsgstael redldqaktq igmtesllka lspsdsleif tkleeiqqqi lqqkhsmill
     1801 enqigcltpe lselkkqyes vsdlfntkks vlqdhfskll ndqcknfndw fsnikvnlke
     1861 cfessetkks veqklqklsd fltlegrnsk ikqvdsvlkh vkkhlpkahv keliswlvgq
     1921 efelekmesi cqarakeled slqqllrlqd dhrnlrkwlt nqeekwkgme epgektelfc
     1981 qalarkreqf esvaqlnnsl keygfteeee iimeatclmd ryqtllrqls eieeedkllp
     2041 tedqsfndla hdvihwikei keslmvlnss egkmpleeri qkikeiillk pegdarieti
     2101 mkqaesseap lvqktltdis nqwdntlhla stylshqekl llegekylqs kedlrlmlie
     2161 lkkkqeagfa lqhglqekka qlkiykkflk kaqdltsllk elksqgnyll ectknpsfse
     2221 epwleikhlh esllqqlqds vqnldghvre hdsyqvcvtd lnttldnfsk efvsfsdkpv
     2281 dqiaveeklq klqelenrls lqdgtlkkil alaksvkqnt ssvgqkiikd dikslqckqk
     2341 dlenrlasak qemecclnsi lkskrstekk gkftlpgrek qatsdvqest qesaavekle
     2401 edweinkdsa vemamskqls lnaqesmknt ederkvnelq nqpleldtml rneqleeiek
     2461 lytqleakka aikpleqtec lnktetgalv lhnigysaqh ldnllqalit lkknkesqyc
     2521 vlrdfqeyla avessmkall tdkeslkvgp ldsvtyldki kkfiasieke kdslgnlkik
     2581 wenlsnhvtd mdkkllesqi kqlehgweqv eqqiqkkysq qvveydeftt lmnkvqdtei
     2641 slqqqqqhlq lrlkspeera gnqsmialtt dlqatkhgfs vlkgqaelqm kriwgekekk
     2701 nledginnlk kqwetleplh leaenqikkc dirnkmketi lwaknllgel npsipllpdd
     2761 ilsqirkckv thdgilarqq sveslaeevk dkvpslttye gsdlnntled lrnqyqmlvl
     2821 kstqrsqqle fkleersnff aiirkfqlmv qesetliipr vetaateael khhhvtleas
     2881 qkelqeidsg isthlqeltn iyeelnvfer lfledqlknl kirtnriqrf iqntcneveh
     2941 kikfcrqfhe ktsalqeead siqrnellln qevnkgvkee iynlkdrlta ikccilqvlk
     3001 lkkvfdyigl nwdfsqldql qtqvfekeke leekikqldt feeehgkyqa llskmraidl
     3061 qikkmtevvl kapdsspesr rlnaqilsqr iekakclcde iikklnenkt fddsfkekei
     3121 lqiklnaeen dklykvlqnm vlelspkeld ekncqdklet slhvlnqiks qlqqpllinl
     3181 eikhiqnekd nceafqeqvw aemcsikavt aiekqreens seasdvetkl refedlqmql
     3241 ntsidlrtnv lndayenltr ykeavtrave sitsleaiii pyrvdvgnpe eslemplrkq
     3301 eelestvahi qdlteklgmi sspeaklqlq ytlqelvskn samkeafkaq eteaerylen
     3361 ykcyrkmeed iytnlskmet vlgqsmsslp lsyrealerl eqskalvsnl istkeelmkl
     3421 rqilrllrlr ctendgicll kivsalwekw lslleaakew emwceelkqe wkfvseeier
     3481 eaiildnlqe elpeisktke aatteelsel ldclcqygen vekqqllltl llqrirsiqn
     3541 vpessgavet vpafqeitsm kercnkllqk vqknkelvqt eiqerhsftk eiialknffq
     3601 qtttsfqnma fqdhpekseq feelqsilkk gkltfenime klrikysemy tivpaeiesq
     3661 veecrkaled idekisnevl ksspsyamrr kieeinnglh nvekmlqqks kniekaqeiq
     3721 kkmwdeldlw hsklneldse vqdiveqdpg qaqewmdnlm ipfqqyqqvs qraecrtsql
     3781 nkatvkmeey sdllksteaw ientshllan padydslrtl shhastvqma ledseqkhnl
     3841 lhsifmdled lsiifetdel tqsiqelsnq vtalqqkime slpqiqrmad dvvaiesevk
     3901 smekrvskik tillskeifd fspeehlkhg evilenirpm kktiaeivsy qvelrlpqtg
     3961 mkplpvfqrt nqllqdikll envtqeqnel lkvvikqtne wdeeienlkq ilnnysaqfs
     4021 lehmspdqad klpqlqgeie rmekqilsln qrkedllvdl katvlnlhqh lkqeqegver
     4081 drlpavtsee ggvaerdase rklnrrgsms ylaaveeeve essvksdngd ekaepspqsw
     4141 sslwkhdkdm eedrassssg tivqeaygki stsdnsmaqi ltpdslnteq gpecslrpnq
     4201 teegttppie adtldssdaq ggleprvekt rpeptevlha cktqvaelel wlqqanvave
     4261 petlnadmqq vleqqlvgcq amlteiehkv aflletckdq glgdngatqh eaealslklk
     4321 tvkcnlekvq mmlqekhsed qhptilkkss epehqealqp vnlselesiv terpqfsrqk
     4381 dfqqqqvlel kpmeqkdfik fiefnakkmw pqycqhdndt tqessasnqa sspendvpds
     4441 ilspqgqngd kwqylhhels skiklplpql vepqvstnmg ilpsvtmynf ryptteelkt
     4501 yttqledlrq easnlqtqen mteeayinld kklfelfltl sqclssveem lemprlyred
     4561 gsgqqvhyet lalelkklyl alsdkkgdll kamtwpgent nlllecfdnl qvclehtqaa
     4621 avcrskslka gldynrsyqn eikrlyhqli ksktslqqsl neisgqsvae qlqkadaytv
     4681 elenaesrva klrdegerlh lpyallqevy kledvldsmw gmlrarytel sspfvtesqq
     4741 dallqgmvel vkigkeklah ghlkqtkskv alqaqienhk vffqklvadm lliqaysaki
     4801 lpsllqnret fwaeqvtevk ileeksrqcg mklqsllqkw eefdenyasl ekdleilist
     4861 lpsvslveet eerlverisf yqqikrnigg kharlyqtln egkqlvasvs cpelegqiak
     4921 leeqwlslnk kidhelhrlq allkhllsyn rdsdqltkwl essqhtlnyw keqslnvsqd
     4981 ldtirsninn ffefskevde ksslktavis ignqllhlke tdtatlrasl aqfeqkwtml
     5041 itqlpdiqek lhqlqmeklp srkaitemis wmnnvehqts dedsvhspss asqvkhllqk
     5101 hkefrmemdy kqwivdfvnq sllqlstcdv eskryertef aehlgemnrq whrvhgmlnr
     5161 kiqhleqlle sitesenkiq ilnnwleaqe erlktlqkpe svisvqklll dcqdienqla
     5221 ikskaldelk qsyltlesga vplledtasr idelfqkrss vltqvnqlkt smqsvlqewk
     5281 iydqlydevn mmtirfwycm ehskpvvlsl etlrcqvenl qslqdeaess egsweklqev
     5341 igklkglcps vaeiieekcq nthkrwtqvn qaiadqlqka qsllqlwkay snahgeaaar
     5401 lkqqeakfqq lanismsgnn laeilppalq dikelqhdvq ktkeaflqns svldrlpqpa
     5461 essthmllpg plhslqraay lekmllvkan efefvlsqfk dfgvrleslk glimheeenl
     5521 drlhqqeken pdsflnhvla ltaqspdieh lnevslklpl sdvavktlqn mnrqwirata
     5581 talercselq giglnekfly ccekwiqlle kieealkvdv anslpelleq qktykmleae
     5641 vsinqtiads yvtqslqlld tteienrpef itefskltdr wqnavqgvrq rkgdvdglvr
     5701 qwqdfttsve nlfrfltdts hllsavkgqe rfslyqtrsl ihelknkeih fqrrrttcal
     5761 tleageklll ttdlktkesv grrisqlqds wkdmepqlae mikqfqstve twdqcekkik
     5821 elksrlqvlk aqsedplpel hedlhnekel ikeleqslas wtqnlkelqt mkadltrhvl
     5881 vedvmvlkeq iehlhrqwed lclrvairkq eiedrlntwv vfneknkelc awlvqmenkv
     5941 lqtadisiee mieklqkdcm eeinlfsenk lqlkqmgdql ikasnksraa eiddklnkin
     6001 drwqhlfdvi gsrvkklket fafiqqldkn msnlrtwlar ieselskpvv ydvcddqeiq
     6061 krlaeqqdlq rdieqhsagv esvfnicdvl lhdsdacane tecdsiqqtt rsldrrwrni
     6121 camsmerrmk ieetwrlwqk flddysrfed wlksaertaa cpnssevlyt sakeelkrfe
     6181 afqrqiherl tqlelinkqy rrlarenrtd tasrlkqmvh egnqrwdnlq rrvtavlrrl
     6241 rhftnqreef egtresilvw ltemdlqltn vehfsesdad dkmrqlngfq qeitlntnki
     6301 dqlivfgeql iqksepldav liedeleelh rycqevfgrv srfhrrltsc tpgledekea
     6361 senetdmedp reiqtdswrk rgeseepssp qslchlvapg hersgcetpv svdsiplewd
     6421 htgdvggsss heedeegpyy salsdveipe npeaylkmtt ktlkassgks isdghswhvp
     6481 dspscpehhy kqmegdrnvp pvppasstpy kppygklllp pgtdggkegp rvlngnpqqe
     6541 dgglagiteq qsgtacnwqs sreaeygafd rwemiqaqel hnklkikqnl qqlnsdisai
     6601 ttwlkkteae lemlkmakpp sdiqeielrv krlqeilkaf dtykalvvsv nvsskeflqt
     6661 espestelqs rlrqlsllwe aaqgavdswr gglrqslmqc qgsktrprsd vlffkdfhql
     6721 sqnlllwlas aknrrqkahv tdpkadpral lecrrelmql ekelverqpq vdmlqeisns
     6781 llikghgedc ieaeekvhvi ekklkqlreq vsqdlmalqg tqnpasplps fdevdsgdqp
     6841 patsvpapra kqfravrtte geeetesrvp gstrpqrsfl srvvraalpl qlllllllll
     6901 acllpsseed ysctqannfa rsfypmlryt ngpppt
//
LOCUS       XP_011534879            6936 aa            linear   PRI 05-AUG-2025
DEFINITION  nesprin-2 isoform X1 [Homo sapiens].
ACCESSION   XP_011534879
VERSION     XP_011534879.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536577.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..6936
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..6936
                     /product="nesprin-2 isoform X1"
                     /calculated_mol_wt=802067
     Region          28..138
                     /region_name="CH_SYNE2_rpt1"
                     /note="first calponin homology (CH) domain found in
                     synaptic nuclear envelope protein 2; cd21242"
                     /db_xref="CDD:409091"
     Site            order(33,37,89,91..92,95..96,98,107..115,120,122..123,
                     125..126,129..130,133)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409091"
     Region          178..286
                     /region_name="CH_SYNE2_rpt2"
                     /note="second calponin homology (CH) domain found in
                     synaptic nuclear envelope protein 2 (SYNE-2) and similar
                     proteins; cd21244"
                     /db_xref="CDD:409093"
     Site            order(183,187,237,239..240,243..244,246,255..263,270,
                     272..273,275..276,279..280,283)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409093"
     Region          <1418..2014
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          <1868..>2369
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          <2338..2712
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          2805..>3389
                     /region_name="CCDC158"
                     /note="Coiled-coil domain-containing protein 158;
                     pfam15921"
                     /db_xref="CDD:464943"
     Region          <3656..>3950
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <3811..4113
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <4496..5321
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          4945..5169
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            5054..5059
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5063..5276
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Region          5123..>5875
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Site            5168..5173
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5178..5384
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cl02488"
                     /db_xref="CDD:413338"
     Site            5275..5280
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5919..6133
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6020..6025
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          6137..6350
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6243..6248
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          6590..6813
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6696..6701
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          <6905..6936
                     /region_name="KASH"
                     /note="Nuclear envelope localization domain; pfam10541"
                     /db_xref="CDD:463142"
     CDS             1..6936
                     /gene="SYNE2"
                     /gene_synonym="EDMD5; KASH2; Nesp2; Nesprin-2; NUA;
                     NUANCE; SYNE-2; TROPH"
                     /coded_by="XM_011536577.3:129..20939"
                     /db_xref="GeneID:23224"
                     /db_xref="HGNC:HGNC:17084"
                     /db_xref="MIM:608442"
ORIGIN      
        1 masspelpte deqgswgidd lhislqaeqe dtqkkaftcw insqlarhts psvisdlftd
       61 ikkghvlldl levlsgqqlp rdkgsntfqc riniehaltf lrnrsiklin ihvtdiidgn
      121 psiilgliwt iilhfhiekl aqtlscnynq pslddvsvvd sspassppak kcskvqarwq
      181 msarkalllw aqeqcatyes vnvtdfkssw rngmaflaii halrpdlidm ksvkhrsnkd
      241 nlreafriae qelkiprlle pedvdvvdpd eksimtyvaq flqyskdapg tgeeaqgkvk
      301 damgwltlqk eklqkllkds endtyfkkyn sllsfmesfn eekksfldvl sikrdldeld
      361 kdhlqlreaw dgldhqinaw kiklnyalpp plhqteawlq eveelmdedl sasqdhsqav
      421 tliqekmtlf kslmdrfehh snilltfenk denhlplvpp nkleemkrri nnilekkfil
      481 llefhyykcl vlglvdevks kldiwnikyg sresvellle dwhkfieeke flarldtsfq
      541 kcgeiyknla gecqninkqy mmvksdvcmy rkniynvkst lqkvlacwat yvenlrllra
      601 cfeetkkeei kevpfetlaq wnlehatlne agnflvevsn dvvgssiske lrrlnkrwrk
      661 lvsktqlemn lplmikkqdq ptfdnsgnil skeekatvef stdmsvelpe nynqnikage
      721 khekeneeft gqlkvakdve kligqveiwe aeaksvldqd dvdtsmeesl khliakgsmf
      781 delmarsedm lqmdiqniss qesfqhvltt glqakiqeak ekvqinvvkl iaalknltdv
      841 spdldirlkm eesqkelesy mmraqqllgq respgelisk hkealiisnt kslakylkav
      901 eelknnvted ikmsleeksr dvcakweslh helslyvqql kidiekgkls dnilklekqi
      961 nkekklirrg rtkglikehe acfseegcly qlnhhmevlr elceelpsqk sqqevkrllk
     1021 dyeqkierll kcaseihmtl qptaggtskn egtittsenr ggdphseapf aksdnqpste
     1081 kameptmkfs lasvlrplqe esimekdysa sinslleryd tyrdilehhl qnnkfritsd
     1141 fsseedrsss clqakltdlq viknetdarw kefeiislkl enhvndikkp fvikerdtlk
     1201 ererelqmtl ntrmesleta lrlvlpveka slllcgsdlp lhkmaiqgfh lidadriyqh
     1261 lrniqdsiak qieicnrlee pgnfvlkelh pfdlhamqni ilkyktqfeg mnhrvqrsed
     1321 tlkaledfla slrtaklsae pvtdlsasdt qvaqentltv knkegeihlm kdkakhldkc
     1381 lkmldmsfkd aergddtsce nlldafsikl sethgygvqe efteenklle acifknnell
     1441 kniqdvqsqi skiglkdptv pavkhrkksl irldkvldey eeekrhlqem anslphfkdg
     1501 rektvnqqcq ntvvlwentk alvtecleqc grvlellkqy qnfksilttl iqkeesvisl
     1561 qasymgkenl kkriaeieiv keefnehlev vdkinqvckn lqfylnkmkt feeppfekea
     1621 niivdrwldi nektedyyen lgralalwdk lfnlknvide wtekalqkme lhqlteedre
     1681 rlkeelqvhe qktsefsrrv aeiqfllqss eiplelqvme ssilnkmehv qkcltgesnc
     1741 halsgstael redldqaktq igmtesllka lspsdsleif tkleeiqqqi lqqkhsmill
     1801 enqigcltpe lselkkqyes vsdlfntkks vlqdhfskll ndqcknfndw fsnikvnlke
     1861 cfessetkks veqklqklsd fltlegrnsk ikqvdsvlkh vkkhlpkahv keliswlvgq
     1921 efelekmesi cqarakeled slqqllrlqd dhrnlrkwlt nqeekwkgme epgektelfc
     1981 qalarkreqf esvaqlnnsl keygfteeee iimeatclmd ryqtllrqls eieeedkllp
     2041 tedqsfndla hdvihwikei keslmvlnss egkmpleeri qkikeiillk pegdarieti
     2101 mkqaesseap lvqktltdis nqwdntlhla stylshqekl llegekylqs kedlrlmlie
     2161 lkkkqeagfa lqhglqekka qlkiykkflk kaqdltsllk elksqgnyll ectknpsfse
     2221 epwleikhlh esllqqlqds vqnldghvre hdsyqvcvtd lnttldnfsk efvsfsdkpv
     2281 dqiaveeklq klqelenrls lqdgtlkkil alaksvkqnt ssvgqkiikd dikslqckqk
     2341 dlenrlasak qemecclnsi lkskrstekk gkftlpgrek qatsdvqest qesaavekle
     2401 edweinkdsa vemamskqls lnaqesmknt ederkvnelq nqpleldtml rneqleeiek
     2461 lytqleakka aikpleqtec lnktetgalv lhnigysaqh ldnllqalit lkknkesqyc
     2521 vlrdfqeyla avessmkall tdkeslkvgp ldsvtyldki kkfiasieke kdslgnlkik
     2581 wenlsnhvtd mdkkllesqi kqlehgweqv eqqiqkkysq qvveydeftt lmnkvqdtei
     2641 slqqqqqhlq lrlkspeera gnqsmialtt dlqatkhgfs vlkgqaelqm kriwgekekk
     2701 nledginnlk kqwetleplh leaenqikkc dirnkmketi lwaknllgel npsipllpdd
     2761 ilsqirkckv thdgilarqq sveslaeevk dkvpslttye gsdlnntled lrnqyqmlvl
     2821 kstqrsqqle fkleersnff aiirkfqlmv qesetliipr vetaateael khhhvtleas
     2881 qkelqeidsg isthlqeltn iyeelnvfer lfledqlknl kirtnriqrf iqntcneveh
     2941 kikfcrqfhe ktsalqeead siqrnellln qevnkgvkee iynlkdrlta ikccilqvlk
     3001 lkkvfdyigl nwdfsqldql qtqvfekeke leekikqldt feeehgkyqa llskmraidl
     3061 qikkmtevvl kapdsspesr rlnaqilsqr iekakclcde iikklnenkt fddsfkekei
     3121 lqiklnaeen dklykvlqnm vlelspkeld ekncqdklet slhvlnqiks qlqqpllinl
     3181 eikhiqnekd nceafqeqvw aemcsikavt aiekqreens seasdvetkl refedlqmql
     3241 ntsidlrtnv lndayenltr ykeavtrave sitsleaiii pyrvdvgnpe eslemplrkq
     3301 eelestvahi qdlteklgmi sspeaklqlq ytlqelvskn samkeafkaq eteaerylen
     3361 ykcyrkmeed iytnlskmet vlgqsmsslp lsyrealerl eqskalvsnl istkeelmkl
     3421 rqilrllrlr ctendgicll kivsalwekw lslleaakew emwceelkqe wkfvseeier
     3481 eaiildnlqe elpeisktke aatteelsel ldclcqygen vekqqllltl llqrirsiqn
     3541 vpessgavet vpafqeitsm kercnkllqk vqknkelvqt eiqerhsftk eiialknffq
     3601 qtttsfqnma fqdhpekseq feelqsilkk gkltfenime klrikysemy tivpaeiesq
     3661 veecrkaled idekisnevl ksspsyamrr kieeinnglh nvekmlqqks kniekaqeiq
     3721 kkmwdeldlw hsklneldse vqdiveqdpg qaqewmdnlm ipfqqyqqvs qraecrtsql
     3781 nkatvkmeey sdllksteaw ientshllan padydslrtl shhastvqma ledseqkhnl
     3841 lhsifmdled lsiifetdel tqsiqelsnq vtalqqkime slpqiqrmad dvvaiesevk
     3901 smekrvskik tillskeifd fspeehlkhg evilenirpm kktiaeivsy qvelrlpqtg
     3961 mkplpvfqrt nqllqdikll envtqeqnel lkvvikqtne wdeeienlkq ilnnysaqfs
     4021 lehmspdqad klpqlqgeie rmekqilsln qrkedllvdl katvlnlhqh lkqeqegver
     4081 drlpavtsee ggvaerdase rklnrrgsms ylaaveeeve essvksdngd ekaepspqsw
     4141 sslwkhdkdm eedrassssg tivqeaygki stsdnsmaqi ltpdslnteq gpecslrpnq
     4201 teegttppie adtldssdaq ggleprvekt rpeptevlha cktqvaelel wlqqanvave
     4261 petlnadmqq vleqqlvgcq amlteiehkv aflletckdq glgdngatqh eaealslklk
     4321 tvkcnlekvq mmlqekhsed qhptilkkss epehqealqp vnlselesiv terpqfsrqk
     4381 dfqqqqvlel kpmeqkdfik fiefnakkmw pqycqhdndt tqessasnqa sspendvpds
     4441 ilspqgqngd kwqylhhels skiklplpql vepqvstnmg ilpsvtmynf ryptteelkt
     4501 yttqledlrq easnlqtqen mteeayinld kklfelfltl sqclssveem lemprlyred
     4561 gsgqqvhyet lalelkklyl alsdkkgdll kamtwpgent nlllecfdnl qvclehtqaa
     4621 avcrskslka gldynrsyqn eikrlyhqli ksktslqqsl neisgqsvae qlqkadaytv
     4681 elenaesrva klrdegerlh lpyallqevy kledvldsmw gmlrarytel sspfvtesqq
     4741 dallqgmvel vkigkeklah ghlkqtkskv alqaqienhk vffqklvadm lliqaysaki
     4801 lpsllqnret fwaeqvtevk ileeksrqcg mklqsllqkw eefdenyasl ekdleilist
     4861 lpsvslveet eerlverisf yqqikrnigg kharlyqtln egkqlvasvs cpelegqiak
     4921 leeqwlslnk kidhelhrlq allkhllsyn rdsdqltkwl essqhtlnyw keqslnvsqd
     4981 ldtirsninn ffefskevde ksslktavis ignqllhlke tdtatlrasl aqfeqkwtml
     5041 itqlpdiqek lhqlqmeklp srkaitemis wmnnvehqts dedsvhspss asqvkhllqk
     5101 hkefrmemdy kqwivdfvnq sllqlstcdv eskryertef aehlgemnrq whrvhgmlnr
     5161 kiqhleqlle sitesenkiq ilnnwleaqe erlktlqkpe svisvqklll dcqdienqla
     5221 ikskaldelk qsyltlesga vplledtasr idelfqkrss vltqvnqlkt smqsvlqewk
     5281 iydqlydevn mmtirfwycm ehskpvvlsl etlrcqvenl qslqdeaess egsweklqev
     5341 igklkglcps vaeiieekcq nthkrwtqvn qaiadqlqka qsllqlwkay snahgeaaar
     5401 lkqqeakfqq lanismsgnn laeilppalq dikelqhdvq ktkeaflqns svldrlpqpa
     5461 essthmllpg plhslqraay lekmllvkan efefvlsqfk dfgvrleslk glimheeenl
     5521 drlhqqeken pdsflnhvla ltaqspdieh lnevslklpl sdvavktlqn mnrqwirata
     5581 talercselq giglnekfly ccekwiqlle kieealkvdv anslpelleq qktykmleae
     5641 vsinqtiads yvtqslqlld tteienrpef itefskltdr wqnavqgvrq rkgdvdglvr
     5701 qwqdfttsve nlfrfltdts hllsavkgqe rfslyqtrsl ihelknkeih fqrrrttcal
     5761 tleageklll ttdlktkesv grrisqlqds wkdmepqlae mikqfqstve twdqcekkik
     5821 elksrlqvlk aqsedplpel hedlhnekel ikeleqslas wtqnlkelqt mkadltrhvl
     5881 vedvmvlkeq iehlhrqwed lclrvairkq eiedrlntwv vfneknkelc awlvqmenkv
     5941 lqtadisiee mieklqkdcm eeinlfsenk lqlkqmgdql ikasnksraa eiddklnkin
     6001 drwqhlfdvi gsrvkklket fafiqqldkn msnlrtwlar ieselskpvv ydvcddqeiq
     6061 krlaeqqdlq rdieqhsagv esvfnicdvl lhdsdacane tecdsiqqtt rsldrrwrni
     6121 camsmerrmk ieetwrlwqk flddysrfed wlksaertaa cpnssevlyt sakeelkrfe
     6181 afqrqiherl tqlelinkqy rrlarenrtd tasrlkqmvh egnqrwdnlq rrvtavlrrl
     6241 rhftnqreef egtresilvw ltemdlqltn vehfsesdad dkmrqlngfq qeitlntnki
     6301 dqlivfgeql iqksepldav liedeleelh rycqevfgrv srfhrrltsc tpgledekea
     6361 senetdmedp reiqtdswrk rgeseepssp qslchlvapg hersgcetpv svdsiplewd
     6421 htgdvggsss heedeegpyy salsdveipe npeaylkmtt ktlkassgks isdghswhvp
     6481 dspscpehhy kqmegdrnvp pvppasstpy kppygklllp pgtdggkegp rvlngnpqqe
     6541 dgglagiteq qsgtacnwqs sreaeygafd rwemiqaqel hnklkikqnl qqlnsdisai
     6601 ttwlkkteae lemlkmakpp sdiqeielrv krlqeilkaf dtykalvvsv nvsskeflqt
     6661 espestelqs rlrqlsllwe aaqgavdswr gglrqslmqc qgsktrprsd vlffkdfhql
     6721 sqnlllwlas aknrrqkahv tdpkadpral lecrrelmql ekelverqpq vdmlqeisns
     6781 llikghgedc ieaeekvhvi ekklkqlreq vsqdlmalqg tqnpasplps fdevdsgdqp
     6841 patsvpapra kqfravrtte geeetesrvp gstrpqrsfl srvvraalpl qlllllllll
     6901 acllpsseed ysctqannfa rsfypmlryt ngpppt
//
LOCUS       XP_047287105            6936 aa            linear   PRI 05-AUG-2025
DEFINITION  nesprin-2 isoform X1 [Homo sapiens].
ACCESSION   XP_047287105
VERSION     XP_047287105.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431149.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..6936
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..6936
                     /product="nesprin-2 isoform X1"
                     /calculated_mol_wt=802067
     Region          28..138
                     /region_name="CH_SYNE2_rpt1"
                     /note="first calponin homology (CH) domain found in
                     synaptic nuclear envelope protein 2; cd21242"
                     /db_xref="CDD:409091"
     Site            order(33,37,89,91..92,95..96,98,107..115,120,122..123,
                     125..126,129..130,133)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409091"
     Region          178..286
                     /region_name="CH_SYNE2_rpt2"
                     /note="second calponin homology (CH) domain found in
                     synaptic nuclear envelope protein 2 (SYNE-2) and similar
                     proteins; cd21244"
                     /db_xref="CDD:409093"
     Site            order(183,187,237,239..240,243..244,246,255..263,270,
                     272..273,275..276,279..280,283)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409093"
     Region          <1418..2014
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          <1868..>2369
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          <2338..2712
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          2805..>3389
                     /region_name="CCDC158"
                     /note="Coiled-coil domain-containing protein 158;
                     pfam15921"
                     /db_xref="CDD:464943"
     Region          <3656..>3950
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <3811..4113
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <4496..5321
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          4945..5169
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            5054..5059
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5063..5276
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Region          5123..>5875
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Site            5168..5173
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5178..5384
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cl02488"
                     /db_xref="CDD:413338"
     Site            5275..5280
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5919..6133
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6020..6025
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          6137..6350
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6243..6248
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          6590..6813
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6696..6701
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          <6905..6936
                     /region_name="KASH"
                     /note="Nuclear envelope localization domain; pfam10541"
                     /db_xref="CDD:463142"
     CDS             1..6936
                     /gene="SYNE2"
                     /gene_synonym="EDMD5; KASH2; Nesp2; Nesprin-2; NUA;
                     NUANCE; SYNE-2; TROPH"
                     /coded_by="XM_047431149.1:196..21006"
                     /db_xref="GeneID:23224"
                     /db_xref="HGNC:HGNC:17084"
                     /db_xref="MIM:608442"
ORIGIN      
        1 masspelpte deqgswgidd lhislqaeqe dtqkkaftcw insqlarhts psvisdlftd
       61 ikkghvlldl levlsgqqlp rdkgsntfqc riniehaltf lrnrsiklin ihvtdiidgn
      121 psiilgliwt iilhfhiekl aqtlscnynq pslddvsvvd sspassppak kcskvqarwq
      181 msarkalllw aqeqcatyes vnvtdfkssw rngmaflaii halrpdlidm ksvkhrsnkd
      241 nlreafriae qelkiprlle pedvdvvdpd eksimtyvaq flqyskdapg tgeeaqgkvk
      301 damgwltlqk eklqkllkds endtyfkkyn sllsfmesfn eekksfldvl sikrdldeld
      361 kdhlqlreaw dgldhqinaw kiklnyalpp plhqteawlq eveelmdedl sasqdhsqav
      421 tliqekmtlf kslmdrfehh snilltfenk denhlplvpp nkleemkrri nnilekkfil
      481 llefhyykcl vlglvdevks kldiwnikyg sresvellle dwhkfieeke flarldtsfq
      541 kcgeiyknla gecqninkqy mmvksdvcmy rkniynvkst lqkvlacwat yvenlrllra
      601 cfeetkkeei kevpfetlaq wnlehatlne agnflvevsn dvvgssiske lrrlnkrwrk
      661 lvsktqlemn lplmikkqdq ptfdnsgnil skeekatvef stdmsvelpe nynqnikage
      721 khekeneeft gqlkvakdve kligqveiwe aeaksvldqd dvdtsmeesl khliakgsmf
      781 delmarsedm lqmdiqniss qesfqhvltt glqakiqeak ekvqinvvkl iaalknltdv
      841 spdldirlkm eesqkelesy mmraqqllgq respgelisk hkealiisnt kslakylkav
      901 eelknnvted ikmsleeksr dvcakweslh helslyvqql kidiekgkls dnilklekqi
      961 nkekklirrg rtkglikehe acfseegcly qlnhhmevlr elceelpsqk sqqevkrllk
     1021 dyeqkierll kcaseihmtl qptaggtskn egtittsenr ggdphseapf aksdnqpste
     1081 kameptmkfs lasvlrplqe esimekdysa sinslleryd tyrdilehhl qnnkfritsd
     1141 fsseedrsss clqakltdlq viknetdarw kefeiislkl enhvndikkp fvikerdtlk
     1201 ererelqmtl ntrmesleta lrlvlpveka slllcgsdlp lhkmaiqgfh lidadriyqh
     1261 lrniqdsiak qieicnrlee pgnfvlkelh pfdlhamqni ilkyktqfeg mnhrvqrsed
     1321 tlkaledfla slrtaklsae pvtdlsasdt qvaqentltv knkegeihlm kdkakhldkc
     1381 lkmldmsfkd aergddtsce nlldafsikl sethgygvqe efteenklle acifknnell
     1441 kniqdvqsqi skiglkdptv pavkhrkksl irldkvldey eeekrhlqem anslphfkdg
     1501 rektvnqqcq ntvvlwentk alvtecleqc grvlellkqy qnfksilttl iqkeesvisl
     1561 qasymgkenl kkriaeieiv keefnehlev vdkinqvckn lqfylnkmkt feeppfekea
     1621 niivdrwldi nektedyyen lgralalwdk lfnlknvide wtekalqkme lhqlteedre
     1681 rlkeelqvhe qktsefsrrv aeiqfllqss eiplelqvme ssilnkmehv qkcltgesnc
     1741 halsgstael redldqaktq igmtesllka lspsdsleif tkleeiqqqi lqqkhsmill
     1801 enqigcltpe lselkkqyes vsdlfntkks vlqdhfskll ndqcknfndw fsnikvnlke
     1861 cfessetkks veqklqklsd fltlegrnsk ikqvdsvlkh vkkhlpkahv keliswlvgq
     1921 efelekmesi cqarakeled slqqllrlqd dhrnlrkwlt nqeekwkgme epgektelfc
     1981 qalarkreqf esvaqlnnsl keygfteeee iimeatclmd ryqtllrqls eieeedkllp
     2041 tedqsfndla hdvihwikei keslmvlnss egkmpleeri qkikeiillk pegdarieti
     2101 mkqaesseap lvqktltdis nqwdntlhla stylshqekl llegekylqs kedlrlmlie
     2161 lkkkqeagfa lqhglqekka qlkiykkflk kaqdltsllk elksqgnyll ectknpsfse
     2221 epwleikhlh esllqqlqds vqnldghvre hdsyqvcvtd lnttldnfsk efvsfsdkpv
     2281 dqiaveeklq klqelenrls lqdgtlkkil alaksvkqnt ssvgqkiikd dikslqckqk
     2341 dlenrlasak qemecclnsi lkskrstekk gkftlpgrek qatsdvqest qesaavekle
     2401 edweinkdsa vemamskqls lnaqesmknt ederkvnelq nqpleldtml rneqleeiek
     2461 lytqleakka aikpleqtec lnktetgalv lhnigysaqh ldnllqalit lkknkesqyc
     2521 vlrdfqeyla avessmkall tdkeslkvgp ldsvtyldki kkfiasieke kdslgnlkik
     2581 wenlsnhvtd mdkkllesqi kqlehgweqv eqqiqkkysq qvveydeftt lmnkvqdtei
     2641 slqqqqqhlq lrlkspeera gnqsmialtt dlqatkhgfs vlkgqaelqm kriwgekekk
     2701 nledginnlk kqwetleplh leaenqikkc dirnkmketi lwaknllgel npsipllpdd
     2761 ilsqirkckv thdgilarqq sveslaeevk dkvpslttye gsdlnntled lrnqyqmlvl
     2821 kstqrsqqle fkleersnff aiirkfqlmv qesetliipr vetaateael khhhvtleas
     2881 qkelqeidsg isthlqeltn iyeelnvfer lfledqlknl kirtnriqrf iqntcneveh
     2941 kikfcrqfhe ktsalqeead siqrnellln qevnkgvkee iynlkdrlta ikccilqvlk
     3001 lkkvfdyigl nwdfsqldql qtqvfekeke leekikqldt feeehgkyqa llskmraidl
     3061 qikkmtevvl kapdsspesr rlnaqilsqr iekakclcde iikklnenkt fddsfkekei
     3121 lqiklnaeen dklykvlqnm vlelspkeld ekncqdklet slhvlnqiks qlqqpllinl
     3181 eikhiqnekd nceafqeqvw aemcsikavt aiekqreens seasdvetkl refedlqmql
     3241 ntsidlrtnv lndayenltr ykeavtrave sitsleaiii pyrvdvgnpe eslemplrkq
     3301 eelestvahi qdlteklgmi sspeaklqlq ytlqelvskn samkeafkaq eteaerylen
     3361 ykcyrkmeed iytnlskmet vlgqsmsslp lsyrealerl eqskalvsnl istkeelmkl
     3421 rqilrllrlr ctendgicll kivsalwekw lslleaakew emwceelkqe wkfvseeier
     3481 eaiildnlqe elpeisktke aatteelsel ldclcqygen vekqqllltl llqrirsiqn
     3541 vpessgavet vpafqeitsm kercnkllqk vqknkelvqt eiqerhsftk eiialknffq
     3601 qtttsfqnma fqdhpekseq feelqsilkk gkltfenime klrikysemy tivpaeiesq
     3661 veecrkaled idekisnevl ksspsyamrr kieeinnglh nvekmlqqks kniekaqeiq
     3721 kkmwdeldlw hsklneldse vqdiveqdpg qaqewmdnlm ipfqqyqqvs qraecrtsql
     3781 nkatvkmeey sdllksteaw ientshllan padydslrtl shhastvqma ledseqkhnl
     3841 lhsifmdled lsiifetdel tqsiqelsnq vtalqqkime slpqiqrmad dvvaiesevk
     3901 smekrvskik tillskeifd fspeehlkhg evilenirpm kktiaeivsy qvelrlpqtg
     3961 mkplpvfqrt nqllqdikll envtqeqnel lkvvikqtne wdeeienlkq ilnnysaqfs
     4021 lehmspdqad klpqlqgeie rmekqilsln qrkedllvdl katvlnlhqh lkqeqegver
     4081 drlpavtsee ggvaerdase rklnrrgsms ylaaveeeve essvksdngd ekaepspqsw
     4141 sslwkhdkdm eedrassssg tivqeaygki stsdnsmaqi ltpdslnteq gpecslrpnq
     4201 teegttppie adtldssdaq ggleprvekt rpeptevlha cktqvaelel wlqqanvave
     4261 petlnadmqq vleqqlvgcq amlteiehkv aflletckdq glgdngatqh eaealslklk
     4321 tvkcnlekvq mmlqekhsed qhptilkkss epehqealqp vnlselesiv terpqfsrqk
     4381 dfqqqqvlel kpmeqkdfik fiefnakkmw pqycqhdndt tqessasnqa sspendvpds
     4441 ilspqgqngd kwqylhhels skiklplpql vepqvstnmg ilpsvtmynf ryptteelkt
     4501 yttqledlrq easnlqtqen mteeayinld kklfelfltl sqclssveem lemprlyred
     4561 gsgqqvhyet lalelkklyl alsdkkgdll kamtwpgent nlllecfdnl qvclehtqaa
     4621 avcrskslka gldynrsyqn eikrlyhqli ksktslqqsl neisgqsvae qlqkadaytv
     4681 elenaesrva klrdegerlh lpyallqevy kledvldsmw gmlrarytel sspfvtesqq
     4741 dallqgmvel vkigkeklah ghlkqtkskv alqaqienhk vffqklvadm lliqaysaki
     4801 lpsllqnret fwaeqvtevk ileeksrqcg mklqsllqkw eefdenyasl ekdleilist
     4861 lpsvslveet eerlverisf yqqikrnigg kharlyqtln egkqlvasvs cpelegqiak
     4921 leeqwlslnk kidhelhrlq allkhllsyn rdsdqltkwl essqhtlnyw keqslnvsqd
     4981 ldtirsninn ffefskevde ksslktavis ignqllhlke tdtatlrasl aqfeqkwtml
     5041 itqlpdiqek lhqlqmeklp srkaitemis wmnnvehqts dedsvhspss asqvkhllqk
     5101 hkefrmemdy kqwivdfvnq sllqlstcdv eskryertef aehlgemnrq whrvhgmlnr
     5161 kiqhleqlle sitesenkiq ilnnwleaqe erlktlqkpe svisvqklll dcqdienqla
     5221 ikskaldelk qsyltlesga vplledtasr idelfqkrss vltqvnqlkt smqsvlqewk
     5281 iydqlydevn mmtirfwycm ehskpvvlsl etlrcqvenl qslqdeaess egsweklqev
     5341 igklkglcps vaeiieekcq nthkrwtqvn qaiadqlqka qsllqlwkay snahgeaaar
     5401 lkqqeakfqq lanismsgnn laeilppalq dikelqhdvq ktkeaflqns svldrlpqpa
     5461 essthmllpg plhslqraay lekmllvkan efefvlsqfk dfgvrleslk glimheeenl
     5521 drlhqqeken pdsflnhvla ltaqspdieh lnevslklpl sdvavktlqn mnrqwirata
     5581 talercselq giglnekfly ccekwiqlle kieealkvdv anslpelleq qktykmleae
     5641 vsinqtiads yvtqslqlld tteienrpef itefskltdr wqnavqgvrq rkgdvdglvr
     5701 qwqdfttsve nlfrfltdts hllsavkgqe rfslyqtrsl ihelknkeih fqrrrttcal
     5761 tleageklll ttdlktkesv grrisqlqds wkdmepqlae mikqfqstve twdqcekkik
     5821 elksrlqvlk aqsedplpel hedlhnekel ikeleqslas wtqnlkelqt mkadltrhvl
     5881 vedvmvlkeq iehlhrqwed lclrvairkq eiedrlntwv vfneknkelc awlvqmenkv
     5941 lqtadisiee mieklqkdcm eeinlfsenk lqlkqmgdql ikasnksraa eiddklnkin
     6001 drwqhlfdvi gsrvkklket fafiqqldkn msnlrtwlar ieselskpvv ydvcddqeiq
     6061 krlaeqqdlq rdieqhsagv esvfnicdvl lhdsdacane tecdsiqqtt rsldrrwrni
     6121 camsmerrmk ieetwrlwqk flddysrfed wlksaertaa cpnssevlyt sakeelkrfe
     6181 afqrqiherl tqlelinkqy rrlarenrtd tasrlkqmvh egnqrwdnlq rrvtavlrrl
     6241 rhftnqreef egtresilvw ltemdlqltn vehfsesdad dkmrqlngfq qeitlntnki
     6301 dqlivfgeql iqksepldav liedeleelh rycqevfgrv srfhrrltsc tpgledekea
     6361 senetdmedp reiqtdswrk rgeseepssp qslchlvapg hersgcetpv svdsiplewd
     6421 htgdvggsss heedeegpyy salsdveipe npeaylkmtt ktlkassgks isdghswhvp
     6481 dspscpehhy kqmegdrnvp pvppasstpy kppygklllp pgtdggkegp rvlngnpqqe
     6541 dgglagiteq qsgtacnwqs sreaeygafd rwemiqaqel hnklkikqnl qqlnsdisai
     6601 ttwlkkteae lemlkmakpp sdiqeielrv krlqeilkaf dtykalvvsv nvsskeflqt
     6661 espestelqs rlrqlsllwe aaqgavdswr gglrqslmqc qgsktrprsd vlffkdfhql
     6721 sqnlllwlas aknrrqkahv tdpkadpral lecrrelmql ekelverqpq vdmlqeisns
     6781 llikghgedc ieaeekvhvi ekklkqlreq vsqdlmalqg tqnpasplps fdevdsgdqp
     6841 patsvpapra kqfravrtte geeetesrvp gstrpqrsfl srvvraalpl qlllllllll
     6901 acllpsseed ysctqannfa rsfypmlryt ngpppt
//
LOCUS       XP_011534878            6936 aa            linear   PRI 05-AUG-2025
DEFINITION  nesprin-2 isoform X1 [Homo sapiens].
ACCESSION   XP_011534878
VERSION     XP_011534878.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536576.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..6936
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..6936
                     /product="nesprin-2 isoform X1"
                     /calculated_mol_wt=802067
     Region          28..138
                     /region_name="CH_SYNE2_rpt1"
                     /note="first calponin homology (CH) domain found in
                     synaptic nuclear envelope protein 2; cd21242"
                     /db_xref="CDD:409091"
     Site            order(33,37,89,91..92,95..96,98,107..115,120,122..123,
                     125..126,129..130,133)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409091"
     Region          178..286
                     /region_name="CH_SYNE2_rpt2"
                     /note="second calponin homology (CH) domain found in
                     synaptic nuclear envelope protein 2 (SYNE-2) and similar
                     proteins; cd21244"
                     /db_xref="CDD:409093"
     Site            order(183,187,237,239..240,243..244,246,255..263,270,
                     272..273,275..276,279..280,283)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409093"
     Region          <1418..2014
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          <1868..>2369
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          <2338..2712
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          2805..>3389
                     /region_name="CCDC158"
                     /note="Coiled-coil domain-containing protein 158;
                     pfam15921"
                     /db_xref="CDD:464943"
     Region          <3656..>3950
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <3811..4113
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <4496..5321
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          4945..5169
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            5054..5059
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5063..5276
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Region          5123..>5875
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Site            5168..5173
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5178..5384
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cl02488"
                     /db_xref="CDD:413338"
     Site            5275..5280
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5919..6133
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6020..6025
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          6137..6350
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6243..6248
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          6590..6813
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6696..6701
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          <6905..6936
                     /region_name="KASH"
                     /note="Nuclear envelope localization domain; pfam10541"
                     /db_xref="CDD:463142"
     CDS             1..6936
                     /gene="SYNE2"
                     /gene_synonym="EDMD5; KASH2; Nesp2; Nesprin-2; NUA;
                     NUANCE; SYNE-2; TROPH"
                     /coded_by="XM_011536576.3:445..21255"
                     /db_xref="GeneID:23224"
                     /db_xref="HGNC:HGNC:17084"
                     /db_xref="MIM:608442"
ORIGIN      
        1 masspelpte deqgswgidd lhislqaeqe dtqkkaftcw insqlarhts psvisdlftd
       61 ikkghvlldl levlsgqqlp rdkgsntfqc riniehaltf lrnrsiklin ihvtdiidgn
      121 psiilgliwt iilhfhiekl aqtlscnynq pslddvsvvd sspassppak kcskvqarwq
      181 msarkalllw aqeqcatyes vnvtdfkssw rngmaflaii halrpdlidm ksvkhrsnkd
      241 nlreafriae qelkiprlle pedvdvvdpd eksimtyvaq flqyskdapg tgeeaqgkvk
      301 damgwltlqk eklqkllkds endtyfkkyn sllsfmesfn eekksfldvl sikrdldeld
      361 kdhlqlreaw dgldhqinaw kiklnyalpp plhqteawlq eveelmdedl sasqdhsqav
      421 tliqekmtlf kslmdrfehh snilltfenk denhlplvpp nkleemkrri nnilekkfil
      481 llefhyykcl vlglvdevks kldiwnikyg sresvellle dwhkfieeke flarldtsfq
      541 kcgeiyknla gecqninkqy mmvksdvcmy rkniynvkst lqkvlacwat yvenlrllra
      601 cfeetkkeei kevpfetlaq wnlehatlne agnflvevsn dvvgssiske lrrlnkrwrk
      661 lvsktqlemn lplmikkqdq ptfdnsgnil skeekatvef stdmsvelpe nynqnikage
      721 khekeneeft gqlkvakdve kligqveiwe aeaksvldqd dvdtsmeesl khliakgsmf
      781 delmarsedm lqmdiqniss qesfqhvltt glqakiqeak ekvqinvvkl iaalknltdv
      841 spdldirlkm eesqkelesy mmraqqllgq respgelisk hkealiisnt kslakylkav
      901 eelknnvted ikmsleeksr dvcakweslh helslyvqql kidiekgkls dnilklekqi
      961 nkekklirrg rtkglikehe acfseegcly qlnhhmevlr elceelpsqk sqqevkrllk
     1021 dyeqkierll kcaseihmtl qptaggtskn egtittsenr ggdphseapf aksdnqpste
     1081 kameptmkfs lasvlrplqe esimekdysa sinslleryd tyrdilehhl qnnkfritsd
     1141 fsseedrsss clqakltdlq viknetdarw kefeiislkl enhvndikkp fvikerdtlk
     1201 ererelqmtl ntrmesleta lrlvlpveka slllcgsdlp lhkmaiqgfh lidadriyqh
     1261 lrniqdsiak qieicnrlee pgnfvlkelh pfdlhamqni ilkyktqfeg mnhrvqrsed
     1321 tlkaledfla slrtaklsae pvtdlsasdt qvaqentltv knkegeihlm kdkakhldkc
     1381 lkmldmsfkd aergddtsce nlldafsikl sethgygvqe efteenklle acifknnell
     1441 kniqdvqsqi skiglkdptv pavkhrkksl irldkvldey eeekrhlqem anslphfkdg
     1501 rektvnqqcq ntvvlwentk alvtecleqc grvlellkqy qnfksilttl iqkeesvisl
     1561 qasymgkenl kkriaeieiv keefnehlev vdkinqvckn lqfylnkmkt feeppfekea
     1621 niivdrwldi nektedyyen lgralalwdk lfnlknvide wtekalqkme lhqlteedre
     1681 rlkeelqvhe qktsefsrrv aeiqfllqss eiplelqvme ssilnkmehv qkcltgesnc
     1741 halsgstael redldqaktq igmtesllka lspsdsleif tkleeiqqqi lqqkhsmill
     1801 enqigcltpe lselkkqyes vsdlfntkks vlqdhfskll ndqcknfndw fsnikvnlke
     1861 cfessetkks veqklqklsd fltlegrnsk ikqvdsvlkh vkkhlpkahv keliswlvgq
     1921 efelekmesi cqarakeled slqqllrlqd dhrnlrkwlt nqeekwkgme epgektelfc
     1981 qalarkreqf esvaqlnnsl keygfteeee iimeatclmd ryqtllrqls eieeedkllp
     2041 tedqsfndla hdvihwikei keslmvlnss egkmpleeri qkikeiillk pegdarieti
     2101 mkqaesseap lvqktltdis nqwdntlhla stylshqekl llegekylqs kedlrlmlie
     2161 lkkkqeagfa lqhglqekka qlkiykkflk kaqdltsllk elksqgnyll ectknpsfse
     2221 epwleikhlh esllqqlqds vqnldghvre hdsyqvcvtd lnttldnfsk efvsfsdkpv
     2281 dqiaveeklq klqelenrls lqdgtlkkil alaksvkqnt ssvgqkiikd dikslqckqk
     2341 dlenrlasak qemecclnsi lkskrstekk gkftlpgrek qatsdvqest qesaavekle
     2401 edweinkdsa vemamskqls lnaqesmknt ederkvnelq nqpleldtml rneqleeiek
     2461 lytqleakka aikpleqtec lnktetgalv lhnigysaqh ldnllqalit lkknkesqyc
     2521 vlrdfqeyla avessmkall tdkeslkvgp ldsvtyldki kkfiasieke kdslgnlkik
     2581 wenlsnhvtd mdkkllesqi kqlehgweqv eqqiqkkysq qvveydeftt lmnkvqdtei
     2641 slqqqqqhlq lrlkspeera gnqsmialtt dlqatkhgfs vlkgqaelqm kriwgekekk
     2701 nledginnlk kqwetleplh leaenqikkc dirnkmketi lwaknllgel npsipllpdd
     2761 ilsqirkckv thdgilarqq sveslaeevk dkvpslttye gsdlnntled lrnqyqmlvl
     2821 kstqrsqqle fkleersnff aiirkfqlmv qesetliipr vetaateael khhhvtleas
     2881 qkelqeidsg isthlqeltn iyeelnvfer lfledqlknl kirtnriqrf iqntcneveh
     2941 kikfcrqfhe ktsalqeead siqrnellln qevnkgvkee iynlkdrlta ikccilqvlk
     3001 lkkvfdyigl nwdfsqldql qtqvfekeke leekikqldt feeehgkyqa llskmraidl
     3061 qikkmtevvl kapdsspesr rlnaqilsqr iekakclcde iikklnenkt fddsfkekei
     3121 lqiklnaeen dklykvlqnm vlelspkeld ekncqdklet slhvlnqiks qlqqpllinl
     3181 eikhiqnekd nceafqeqvw aemcsikavt aiekqreens seasdvetkl refedlqmql
     3241 ntsidlrtnv lndayenltr ykeavtrave sitsleaiii pyrvdvgnpe eslemplrkq
     3301 eelestvahi qdlteklgmi sspeaklqlq ytlqelvskn samkeafkaq eteaerylen
     3361 ykcyrkmeed iytnlskmet vlgqsmsslp lsyrealerl eqskalvsnl istkeelmkl
     3421 rqilrllrlr ctendgicll kivsalwekw lslleaakew emwceelkqe wkfvseeier
     3481 eaiildnlqe elpeisktke aatteelsel ldclcqygen vekqqllltl llqrirsiqn
     3541 vpessgavet vpafqeitsm kercnkllqk vqknkelvqt eiqerhsftk eiialknffq
     3601 qtttsfqnma fqdhpekseq feelqsilkk gkltfenime klrikysemy tivpaeiesq
     3661 veecrkaled idekisnevl ksspsyamrr kieeinnglh nvekmlqqks kniekaqeiq
     3721 kkmwdeldlw hsklneldse vqdiveqdpg qaqewmdnlm ipfqqyqqvs qraecrtsql
     3781 nkatvkmeey sdllksteaw ientshllan padydslrtl shhastvqma ledseqkhnl
     3841 lhsifmdled lsiifetdel tqsiqelsnq vtalqqkime slpqiqrmad dvvaiesevk
     3901 smekrvskik tillskeifd fspeehlkhg evilenirpm kktiaeivsy qvelrlpqtg
     3961 mkplpvfqrt nqllqdikll envtqeqnel lkvvikqtne wdeeienlkq ilnnysaqfs
     4021 lehmspdqad klpqlqgeie rmekqilsln qrkedllvdl katvlnlhqh lkqeqegver
     4081 drlpavtsee ggvaerdase rklnrrgsms ylaaveeeve essvksdngd ekaepspqsw
     4141 sslwkhdkdm eedrassssg tivqeaygki stsdnsmaqi ltpdslnteq gpecslrpnq
     4201 teegttppie adtldssdaq ggleprvekt rpeptevlha cktqvaelel wlqqanvave
     4261 petlnadmqq vleqqlvgcq amlteiehkv aflletckdq glgdngatqh eaealslklk
     4321 tvkcnlekvq mmlqekhsed qhptilkkss epehqealqp vnlselesiv terpqfsrqk
     4381 dfqqqqvlel kpmeqkdfik fiefnakkmw pqycqhdndt tqessasnqa sspendvpds
     4441 ilspqgqngd kwqylhhels skiklplpql vepqvstnmg ilpsvtmynf ryptteelkt
     4501 yttqledlrq easnlqtqen mteeayinld kklfelfltl sqclssveem lemprlyred
     4561 gsgqqvhyet lalelkklyl alsdkkgdll kamtwpgent nlllecfdnl qvclehtqaa
     4621 avcrskslka gldynrsyqn eikrlyhqli ksktslqqsl neisgqsvae qlqkadaytv
     4681 elenaesrva klrdegerlh lpyallqevy kledvldsmw gmlrarytel sspfvtesqq
     4741 dallqgmvel vkigkeklah ghlkqtkskv alqaqienhk vffqklvadm lliqaysaki
     4801 lpsllqnret fwaeqvtevk ileeksrqcg mklqsllqkw eefdenyasl ekdleilist
     4861 lpsvslveet eerlverisf yqqikrnigg kharlyqtln egkqlvasvs cpelegqiak
     4921 leeqwlslnk kidhelhrlq allkhllsyn rdsdqltkwl essqhtlnyw keqslnvsqd
     4981 ldtirsninn ffefskevde ksslktavis ignqllhlke tdtatlrasl aqfeqkwtml
     5041 itqlpdiqek lhqlqmeklp srkaitemis wmnnvehqts dedsvhspss asqvkhllqk
     5101 hkefrmemdy kqwivdfvnq sllqlstcdv eskryertef aehlgemnrq whrvhgmlnr
     5161 kiqhleqlle sitesenkiq ilnnwleaqe erlktlqkpe svisvqklll dcqdienqla
     5221 ikskaldelk qsyltlesga vplledtasr idelfqkrss vltqvnqlkt smqsvlqewk
     5281 iydqlydevn mmtirfwycm ehskpvvlsl etlrcqvenl qslqdeaess egsweklqev
     5341 igklkglcps vaeiieekcq nthkrwtqvn qaiadqlqka qsllqlwkay snahgeaaar
     5401 lkqqeakfqq lanismsgnn laeilppalq dikelqhdvq ktkeaflqns svldrlpqpa
     5461 essthmllpg plhslqraay lekmllvkan efefvlsqfk dfgvrleslk glimheeenl
     5521 drlhqqeken pdsflnhvla ltaqspdieh lnevslklpl sdvavktlqn mnrqwirata
     5581 talercselq giglnekfly ccekwiqlle kieealkvdv anslpelleq qktykmleae
     5641 vsinqtiads yvtqslqlld tteienrpef itefskltdr wqnavqgvrq rkgdvdglvr
     5701 qwqdfttsve nlfrfltdts hllsavkgqe rfslyqtrsl ihelknkeih fqrrrttcal
     5761 tleageklll ttdlktkesv grrisqlqds wkdmepqlae mikqfqstve twdqcekkik
     5821 elksrlqvlk aqsedplpel hedlhnekel ikeleqslas wtqnlkelqt mkadltrhvl
     5881 vedvmvlkeq iehlhrqwed lclrvairkq eiedrlntwv vfneknkelc awlvqmenkv
     5941 lqtadisiee mieklqkdcm eeinlfsenk lqlkqmgdql ikasnksraa eiddklnkin
     6001 drwqhlfdvi gsrvkklket fafiqqldkn msnlrtwlar ieselskpvv ydvcddqeiq
     6061 krlaeqqdlq rdieqhsagv esvfnicdvl lhdsdacane tecdsiqqtt rsldrrwrni
     6121 camsmerrmk ieetwrlwqk flddysrfed wlksaertaa cpnssevlyt sakeelkrfe
     6181 afqrqiherl tqlelinkqy rrlarenrtd tasrlkqmvh egnqrwdnlq rrvtavlrrl
     6241 rhftnqreef egtresilvw ltemdlqltn vehfsesdad dkmrqlngfq qeitlntnki
     6301 dqlivfgeql iqksepldav liedeleelh rycqevfgrv srfhrrltsc tpgledekea
     6361 senetdmedp reiqtdswrk rgeseepssp qslchlvapg hersgcetpv svdsiplewd
     6421 htgdvggsss heedeegpyy salsdveipe npeaylkmtt ktlkassgks isdghswhvp
     6481 dspscpehhy kqmegdrnvp pvppasstpy kppygklllp pgtdggkegp rvlngnpqqe
     6541 dgglagiteq qsgtacnwqs sreaeygafd rwemiqaqel hnklkikqnl qqlnsdisai
     6601 ttwlkkteae lemlkmakpp sdiqeielrv krlqeilkaf dtykalvvsv nvsskeflqt
     6661 espestelqs rlrqlsllwe aaqgavdswr gglrqslmqc qgsktrprsd vlffkdfhql
     6721 sqnlllwlas aknrrqkahv tdpkadpral lecrrelmql ekelverqpq vdmlqeisns
     6781 llikghgedc ieaeekvhvi ekklkqlreq vsqdlmalqg tqnpasplps fdevdsgdqp
     6841 patsvpapra kqfravrtte geeetesrvp gstrpqrsfl srvvraalpl qlllllllll
     6901 acllpsseed ysctqannfa rsfypmlryt ngpppt
//
LOCUS       XP_011534877            6936 aa            linear   PRI 05-AUG-2025
DEFINITION  nesprin-2 isoform X1 [Homo sapiens].
ACCESSION   XP_011534877
VERSION     XP_011534877.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536575.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..6936
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..6936
                     /product="nesprin-2 isoform X1"
                     /calculated_mol_wt=802067
     Region          28..138
                     /region_name="CH_SYNE2_rpt1"
                     /note="first calponin homology (CH) domain found in
                     synaptic nuclear envelope protein 2; cd21242"
                     /db_xref="CDD:409091"
     Site            order(33,37,89,91..92,95..96,98,107..115,120,122..123,
                     125..126,129..130,133)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409091"
     Region          178..286
                     /region_name="CH_SYNE2_rpt2"
                     /note="second calponin homology (CH) domain found in
                     synaptic nuclear envelope protein 2 (SYNE-2) and similar
                     proteins; cd21244"
                     /db_xref="CDD:409093"
     Site            order(183,187,237,239..240,243..244,246,255..263,270,
                     272..273,275..276,279..280,283)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409093"
     Region          <1418..2014
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          <1868..>2369
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          <2338..2712
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          2805..>3389
                     /region_name="CCDC158"
                     /note="Coiled-coil domain-containing protein 158;
                     pfam15921"
                     /db_xref="CDD:464943"
     Region          <3656..>3950
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <3811..4113
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <4496..5321
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          4945..5169
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            5054..5059
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5063..5276
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Region          5123..>5875
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Site            5168..5173
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5178..5384
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cl02488"
                     /db_xref="CDD:413338"
     Site            5275..5280
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5919..6133
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6020..6025
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          6137..6350
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6243..6248
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          6590..6813
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6696..6701
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          <6905..6936
                     /region_name="KASH"
                     /note="Nuclear envelope localization domain; pfam10541"
                     /db_xref="CDD:463142"
     CDS             1..6936
                     /gene="SYNE2"
                     /gene_synonym="EDMD5; KASH2; Nesp2; Nesprin-2; NUA;
                     NUANCE; SYNE-2; TROPH"
                     /coded_by="XM_011536575.3:278..21088"
                     /db_xref="GeneID:23224"
                     /db_xref="HGNC:HGNC:17084"
                     /db_xref="MIM:608442"
ORIGIN      
        1 masspelpte deqgswgidd lhislqaeqe dtqkkaftcw insqlarhts psvisdlftd
       61 ikkghvlldl levlsgqqlp rdkgsntfqc riniehaltf lrnrsiklin ihvtdiidgn
      121 psiilgliwt iilhfhiekl aqtlscnynq pslddvsvvd sspassppak kcskvqarwq
      181 msarkalllw aqeqcatyes vnvtdfkssw rngmaflaii halrpdlidm ksvkhrsnkd
      241 nlreafriae qelkiprlle pedvdvvdpd eksimtyvaq flqyskdapg tgeeaqgkvk
      301 damgwltlqk eklqkllkds endtyfkkyn sllsfmesfn eekksfldvl sikrdldeld
      361 kdhlqlreaw dgldhqinaw kiklnyalpp plhqteawlq eveelmdedl sasqdhsqav
      421 tliqekmtlf kslmdrfehh snilltfenk denhlplvpp nkleemkrri nnilekkfil
      481 llefhyykcl vlglvdevks kldiwnikyg sresvellle dwhkfieeke flarldtsfq
      541 kcgeiyknla gecqninkqy mmvksdvcmy rkniynvkst lqkvlacwat yvenlrllra
      601 cfeetkkeei kevpfetlaq wnlehatlne agnflvevsn dvvgssiske lrrlnkrwrk
      661 lvsktqlemn lplmikkqdq ptfdnsgnil skeekatvef stdmsvelpe nynqnikage
      721 khekeneeft gqlkvakdve kligqveiwe aeaksvldqd dvdtsmeesl khliakgsmf
      781 delmarsedm lqmdiqniss qesfqhvltt glqakiqeak ekvqinvvkl iaalknltdv
      841 spdldirlkm eesqkelesy mmraqqllgq respgelisk hkealiisnt kslakylkav
      901 eelknnvted ikmsleeksr dvcakweslh helslyvqql kidiekgkls dnilklekqi
      961 nkekklirrg rtkglikehe acfseegcly qlnhhmevlr elceelpsqk sqqevkrllk
     1021 dyeqkierll kcaseihmtl qptaggtskn egtittsenr ggdphseapf aksdnqpste
     1081 kameptmkfs lasvlrplqe esimekdysa sinslleryd tyrdilehhl qnnkfritsd
     1141 fsseedrsss clqakltdlq viknetdarw kefeiislkl enhvndikkp fvikerdtlk
     1201 ererelqmtl ntrmesleta lrlvlpveka slllcgsdlp lhkmaiqgfh lidadriyqh
     1261 lrniqdsiak qieicnrlee pgnfvlkelh pfdlhamqni ilkyktqfeg mnhrvqrsed
     1321 tlkaledfla slrtaklsae pvtdlsasdt qvaqentltv knkegeihlm kdkakhldkc
     1381 lkmldmsfkd aergddtsce nlldafsikl sethgygvqe efteenklle acifknnell
     1441 kniqdvqsqi skiglkdptv pavkhrkksl irldkvldey eeekrhlqem anslphfkdg
     1501 rektvnqqcq ntvvlwentk alvtecleqc grvlellkqy qnfksilttl iqkeesvisl
     1561 qasymgkenl kkriaeieiv keefnehlev vdkinqvckn lqfylnkmkt feeppfekea
     1621 niivdrwldi nektedyyen lgralalwdk lfnlknvide wtekalqkme lhqlteedre
     1681 rlkeelqvhe qktsefsrrv aeiqfllqss eiplelqvme ssilnkmehv qkcltgesnc
     1741 halsgstael redldqaktq igmtesllka lspsdsleif tkleeiqqqi lqqkhsmill
     1801 enqigcltpe lselkkqyes vsdlfntkks vlqdhfskll ndqcknfndw fsnikvnlke
     1861 cfessetkks veqklqklsd fltlegrnsk ikqvdsvlkh vkkhlpkahv keliswlvgq
     1921 efelekmesi cqarakeled slqqllrlqd dhrnlrkwlt nqeekwkgme epgektelfc
     1981 qalarkreqf esvaqlnnsl keygfteeee iimeatclmd ryqtllrqls eieeedkllp
     2041 tedqsfndla hdvihwikei keslmvlnss egkmpleeri qkikeiillk pegdarieti
     2101 mkqaesseap lvqktltdis nqwdntlhla stylshqekl llegekylqs kedlrlmlie
     2161 lkkkqeagfa lqhglqekka qlkiykkflk kaqdltsllk elksqgnyll ectknpsfse
     2221 epwleikhlh esllqqlqds vqnldghvre hdsyqvcvtd lnttldnfsk efvsfsdkpv
     2281 dqiaveeklq klqelenrls lqdgtlkkil alaksvkqnt ssvgqkiikd dikslqckqk
     2341 dlenrlasak qemecclnsi lkskrstekk gkftlpgrek qatsdvqest qesaavekle
     2401 edweinkdsa vemamskqls lnaqesmknt ederkvnelq nqpleldtml rneqleeiek
     2461 lytqleakka aikpleqtec lnktetgalv lhnigysaqh ldnllqalit lkknkesqyc
     2521 vlrdfqeyla avessmkall tdkeslkvgp ldsvtyldki kkfiasieke kdslgnlkik
     2581 wenlsnhvtd mdkkllesqi kqlehgweqv eqqiqkkysq qvveydeftt lmnkvqdtei
     2641 slqqqqqhlq lrlkspeera gnqsmialtt dlqatkhgfs vlkgqaelqm kriwgekekk
     2701 nledginnlk kqwetleplh leaenqikkc dirnkmketi lwaknllgel npsipllpdd
     2761 ilsqirkckv thdgilarqq sveslaeevk dkvpslttye gsdlnntled lrnqyqmlvl
     2821 kstqrsqqle fkleersnff aiirkfqlmv qesetliipr vetaateael khhhvtleas
     2881 qkelqeidsg isthlqeltn iyeelnvfer lfledqlknl kirtnriqrf iqntcneveh
     2941 kikfcrqfhe ktsalqeead siqrnellln qevnkgvkee iynlkdrlta ikccilqvlk
     3001 lkkvfdyigl nwdfsqldql qtqvfekeke leekikqldt feeehgkyqa llskmraidl
     3061 qikkmtevvl kapdsspesr rlnaqilsqr iekakclcde iikklnenkt fddsfkekei
     3121 lqiklnaeen dklykvlqnm vlelspkeld ekncqdklet slhvlnqiks qlqqpllinl
     3181 eikhiqnekd nceafqeqvw aemcsikavt aiekqreens seasdvetkl refedlqmql
     3241 ntsidlrtnv lndayenltr ykeavtrave sitsleaiii pyrvdvgnpe eslemplrkq
     3301 eelestvahi qdlteklgmi sspeaklqlq ytlqelvskn samkeafkaq eteaerylen
     3361 ykcyrkmeed iytnlskmet vlgqsmsslp lsyrealerl eqskalvsnl istkeelmkl
     3421 rqilrllrlr ctendgicll kivsalwekw lslleaakew emwceelkqe wkfvseeier
     3481 eaiildnlqe elpeisktke aatteelsel ldclcqygen vekqqllltl llqrirsiqn
     3541 vpessgavet vpafqeitsm kercnkllqk vqknkelvqt eiqerhsftk eiialknffq
     3601 qtttsfqnma fqdhpekseq feelqsilkk gkltfenime klrikysemy tivpaeiesq
     3661 veecrkaled idekisnevl ksspsyamrr kieeinnglh nvekmlqqks kniekaqeiq
     3721 kkmwdeldlw hsklneldse vqdiveqdpg qaqewmdnlm ipfqqyqqvs qraecrtsql
     3781 nkatvkmeey sdllksteaw ientshllan padydslrtl shhastvqma ledseqkhnl
     3841 lhsifmdled lsiifetdel tqsiqelsnq vtalqqkime slpqiqrmad dvvaiesevk
     3901 smekrvskik tillskeifd fspeehlkhg evilenirpm kktiaeivsy qvelrlpqtg
     3961 mkplpvfqrt nqllqdikll envtqeqnel lkvvikqtne wdeeienlkq ilnnysaqfs
     4021 lehmspdqad klpqlqgeie rmekqilsln qrkedllvdl katvlnlhqh lkqeqegver
     4081 drlpavtsee ggvaerdase rklnrrgsms ylaaveeeve essvksdngd ekaepspqsw
     4141 sslwkhdkdm eedrassssg tivqeaygki stsdnsmaqi ltpdslnteq gpecslrpnq
     4201 teegttppie adtldssdaq ggleprvekt rpeptevlha cktqvaelel wlqqanvave
     4261 petlnadmqq vleqqlvgcq amlteiehkv aflletckdq glgdngatqh eaealslklk
     4321 tvkcnlekvq mmlqekhsed qhptilkkss epehqealqp vnlselesiv terpqfsrqk
     4381 dfqqqqvlel kpmeqkdfik fiefnakkmw pqycqhdndt tqessasnqa sspendvpds
     4441 ilspqgqngd kwqylhhels skiklplpql vepqvstnmg ilpsvtmynf ryptteelkt
     4501 yttqledlrq easnlqtqen mteeayinld kklfelfltl sqclssveem lemprlyred
     4561 gsgqqvhyet lalelkklyl alsdkkgdll kamtwpgent nlllecfdnl qvclehtqaa
     4621 avcrskslka gldynrsyqn eikrlyhqli ksktslqqsl neisgqsvae qlqkadaytv
     4681 elenaesrva klrdegerlh lpyallqevy kledvldsmw gmlrarytel sspfvtesqq
     4741 dallqgmvel vkigkeklah ghlkqtkskv alqaqienhk vffqklvadm lliqaysaki
     4801 lpsllqnret fwaeqvtevk ileeksrqcg mklqsllqkw eefdenyasl ekdleilist
     4861 lpsvslveet eerlverisf yqqikrnigg kharlyqtln egkqlvasvs cpelegqiak
     4921 leeqwlslnk kidhelhrlq allkhllsyn rdsdqltkwl essqhtlnyw keqslnvsqd
     4981 ldtirsninn ffefskevde ksslktavis ignqllhlke tdtatlrasl aqfeqkwtml
     5041 itqlpdiqek lhqlqmeklp srkaitemis wmnnvehqts dedsvhspss asqvkhllqk
     5101 hkefrmemdy kqwivdfvnq sllqlstcdv eskryertef aehlgemnrq whrvhgmlnr
     5161 kiqhleqlle sitesenkiq ilnnwleaqe erlktlqkpe svisvqklll dcqdienqla
     5221 ikskaldelk qsyltlesga vplledtasr idelfqkrss vltqvnqlkt smqsvlqewk
     5281 iydqlydevn mmtirfwycm ehskpvvlsl etlrcqvenl qslqdeaess egsweklqev
     5341 igklkglcps vaeiieekcq nthkrwtqvn qaiadqlqka qsllqlwkay snahgeaaar
     5401 lkqqeakfqq lanismsgnn laeilppalq dikelqhdvq ktkeaflqns svldrlpqpa
     5461 essthmllpg plhslqraay lekmllvkan efefvlsqfk dfgvrleslk glimheeenl
     5521 drlhqqeken pdsflnhvla ltaqspdieh lnevslklpl sdvavktlqn mnrqwirata
     5581 talercselq giglnekfly ccekwiqlle kieealkvdv anslpelleq qktykmleae
     5641 vsinqtiads yvtqslqlld tteienrpef itefskltdr wqnavqgvrq rkgdvdglvr
     5701 qwqdfttsve nlfrfltdts hllsavkgqe rfslyqtrsl ihelknkeih fqrrrttcal
     5761 tleageklll ttdlktkesv grrisqlqds wkdmepqlae mikqfqstve twdqcekkik
     5821 elksrlqvlk aqsedplpel hedlhnekel ikeleqslas wtqnlkelqt mkadltrhvl
     5881 vedvmvlkeq iehlhrqwed lclrvairkq eiedrlntwv vfneknkelc awlvqmenkv
     5941 lqtadisiee mieklqkdcm eeinlfsenk lqlkqmgdql ikasnksraa eiddklnkin
     6001 drwqhlfdvi gsrvkklket fafiqqldkn msnlrtwlar ieselskpvv ydvcddqeiq
     6061 krlaeqqdlq rdieqhsagv esvfnicdvl lhdsdacane tecdsiqqtt rsldrrwrni
     6121 camsmerrmk ieetwrlwqk flddysrfed wlksaertaa cpnssevlyt sakeelkrfe
     6181 afqrqiherl tqlelinkqy rrlarenrtd tasrlkqmvh egnqrwdnlq rrvtavlrrl
     6241 rhftnqreef egtresilvw ltemdlqltn vehfsesdad dkmrqlngfq qeitlntnki
     6301 dqlivfgeql iqksepldav liedeleelh rycqevfgrv srfhrrltsc tpgledekea
     6361 senetdmedp reiqtdswrk rgeseepssp qslchlvapg hersgcetpv svdsiplewd
     6421 htgdvggsss heedeegpyy salsdveipe npeaylkmtt ktlkassgks isdghswhvp
     6481 dspscpehhy kqmegdrnvp pvppasstpy kppygklllp pgtdggkegp rvlngnpqqe
     6541 dgglagiteq qsgtacnwqs sreaeygafd rwemiqaqel hnklkikqnl qqlnsdisai
     6601 ttwlkkteae lemlkmakpp sdiqeielrv krlqeilkaf dtykalvvsv nvsskeflqt
     6661 espestelqs rlrqlsllwe aaqgavdswr gglrqslmqc qgsktrprsd vlffkdfhql
     6721 sqnlllwlas aknrrqkahv tdpkadpral lecrrelmql ekelverqpq vdmlqeisns
     6781 llikghgedc ieaeekvhvi ekklkqlreq vsqdlmalqg tqnpasplps fdevdsgdqp
     6841 patsvpapra kqfravrtte geeetesrvp gstrpqrsfl srvvraalpl qlllllllll
     6901 acllpsseed ysctqannfa rsfypmlryt ngpppt
//
LOCUS       XP_016876590            6936 aa            linear   PRI 05-AUG-2025
DEFINITION  nesprin-2 isoform X1 [Homo sapiens].
ACCESSION   XP_016876590
VERSION     XP_016876590.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021101.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..6936
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..6936
                     /product="nesprin-2 isoform X1"
                     /calculated_mol_wt=802067
     Region          28..138
                     /region_name="CH_SYNE2_rpt1"
                     /note="first calponin homology (CH) domain found in
                     synaptic nuclear envelope protein 2; cd21242"
                     /db_xref="CDD:409091"
     Site            order(33,37,89,91..92,95..96,98,107..115,120,122..123,
                     125..126,129..130,133)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409091"
     Region          178..286
                     /region_name="CH_SYNE2_rpt2"
                     /note="second calponin homology (CH) domain found in
                     synaptic nuclear envelope protein 2 (SYNE-2) and similar
                     proteins; cd21244"
                     /db_xref="CDD:409093"
     Site            order(183,187,237,239..240,243..244,246,255..263,270,
                     272..273,275..276,279..280,283)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409093"
     Region          <1418..2014
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          <1868..>2369
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          <2338..2712
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          2805..>3389
                     /region_name="CCDC158"
                     /note="Coiled-coil domain-containing protein 158;
                     pfam15921"
                     /db_xref="CDD:464943"
     Region          <3656..>3950
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <3811..4113
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <4496..5321
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          4945..5169
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            5054..5059
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5063..5276
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Region          5123..>5875
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Site            5168..5173
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5178..5384
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cl02488"
                     /db_xref="CDD:413338"
     Site            5275..5280
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5919..6133
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6020..6025
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          6137..6350
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6243..6248
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          6590..6813
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6696..6701
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          <6905..6936
                     /region_name="KASH"
                     /note="Nuclear envelope localization domain; pfam10541"
                     /db_xref="CDD:463142"
     CDS             1..6936
                     /gene="SYNE2"
                     /gene_synonym="EDMD5; KASH2; Nesp2; Nesprin-2; NUA;
                     NUANCE; SYNE-2; TROPH"
                     /coded_by="XM_017021101.2:10341..31151"
                     /db_xref="GeneID:23224"
                     /db_xref="HGNC:HGNC:17084"
                     /db_xref="MIM:608442"
ORIGIN      
        1 masspelpte deqgswgidd lhislqaeqe dtqkkaftcw insqlarhts psvisdlftd
       61 ikkghvlldl levlsgqqlp rdkgsntfqc riniehaltf lrnrsiklin ihvtdiidgn
      121 psiilgliwt iilhfhiekl aqtlscnynq pslddvsvvd sspassppak kcskvqarwq
      181 msarkalllw aqeqcatyes vnvtdfkssw rngmaflaii halrpdlidm ksvkhrsnkd
      241 nlreafriae qelkiprlle pedvdvvdpd eksimtyvaq flqyskdapg tgeeaqgkvk
      301 damgwltlqk eklqkllkds endtyfkkyn sllsfmesfn eekksfldvl sikrdldeld
      361 kdhlqlreaw dgldhqinaw kiklnyalpp plhqteawlq eveelmdedl sasqdhsqav
      421 tliqekmtlf kslmdrfehh snilltfenk denhlplvpp nkleemkrri nnilekkfil
      481 llefhyykcl vlglvdevks kldiwnikyg sresvellle dwhkfieeke flarldtsfq
      541 kcgeiyknla gecqninkqy mmvksdvcmy rkniynvkst lqkvlacwat yvenlrllra
      601 cfeetkkeei kevpfetlaq wnlehatlne agnflvevsn dvvgssiske lrrlnkrwrk
      661 lvsktqlemn lplmikkqdq ptfdnsgnil skeekatvef stdmsvelpe nynqnikage
      721 khekeneeft gqlkvakdve kligqveiwe aeaksvldqd dvdtsmeesl khliakgsmf
      781 delmarsedm lqmdiqniss qesfqhvltt glqakiqeak ekvqinvvkl iaalknltdv
      841 spdldirlkm eesqkelesy mmraqqllgq respgelisk hkealiisnt kslakylkav
      901 eelknnvted ikmsleeksr dvcakweslh helslyvqql kidiekgkls dnilklekqi
      961 nkekklirrg rtkglikehe acfseegcly qlnhhmevlr elceelpsqk sqqevkrllk
     1021 dyeqkierll kcaseihmtl qptaggtskn egtittsenr ggdphseapf aksdnqpste
     1081 kameptmkfs lasvlrplqe esimekdysa sinslleryd tyrdilehhl qnnkfritsd
     1141 fsseedrsss clqakltdlq viknetdarw kefeiislkl enhvndikkp fvikerdtlk
     1201 ererelqmtl ntrmesleta lrlvlpveka slllcgsdlp lhkmaiqgfh lidadriyqh
     1261 lrniqdsiak qieicnrlee pgnfvlkelh pfdlhamqni ilkyktqfeg mnhrvqrsed
     1321 tlkaledfla slrtaklsae pvtdlsasdt qvaqentltv knkegeihlm kdkakhldkc
     1381 lkmldmsfkd aergddtsce nlldafsikl sethgygvqe efteenklle acifknnell
     1441 kniqdvqsqi skiglkdptv pavkhrkksl irldkvldey eeekrhlqem anslphfkdg
     1501 rektvnqqcq ntvvlwentk alvtecleqc grvlellkqy qnfksilttl iqkeesvisl
     1561 qasymgkenl kkriaeieiv keefnehlev vdkinqvckn lqfylnkmkt feeppfekea
     1621 niivdrwldi nektedyyen lgralalwdk lfnlknvide wtekalqkme lhqlteedre
     1681 rlkeelqvhe qktsefsrrv aeiqfllqss eiplelqvme ssilnkmehv qkcltgesnc
     1741 halsgstael redldqaktq igmtesllka lspsdsleif tkleeiqqqi lqqkhsmill
     1801 enqigcltpe lselkkqyes vsdlfntkks vlqdhfskll ndqcknfndw fsnikvnlke
     1861 cfessetkks veqklqklsd fltlegrnsk ikqvdsvlkh vkkhlpkahv keliswlvgq
     1921 efelekmesi cqarakeled slqqllrlqd dhrnlrkwlt nqeekwkgme epgektelfc
     1981 qalarkreqf esvaqlnnsl keygfteeee iimeatclmd ryqtllrqls eieeedkllp
     2041 tedqsfndla hdvihwikei keslmvlnss egkmpleeri qkikeiillk pegdarieti
     2101 mkqaesseap lvqktltdis nqwdntlhla stylshqekl llegekylqs kedlrlmlie
     2161 lkkkqeagfa lqhglqekka qlkiykkflk kaqdltsllk elksqgnyll ectknpsfse
     2221 epwleikhlh esllqqlqds vqnldghvre hdsyqvcvtd lnttldnfsk efvsfsdkpv
     2281 dqiaveeklq klqelenrls lqdgtlkkil alaksvkqnt ssvgqkiikd dikslqckqk
     2341 dlenrlasak qemecclnsi lkskrstekk gkftlpgrek qatsdvqest qesaavekle
     2401 edweinkdsa vemamskqls lnaqesmknt ederkvnelq nqpleldtml rneqleeiek
     2461 lytqleakka aikpleqtec lnktetgalv lhnigysaqh ldnllqalit lkknkesqyc
     2521 vlrdfqeyla avessmkall tdkeslkvgp ldsvtyldki kkfiasieke kdslgnlkik
     2581 wenlsnhvtd mdkkllesqi kqlehgweqv eqqiqkkysq qvveydeftt lmnkvqdtei
     2641 slqqqqqhlq lrlkspeera gnqsmialtt dlqatkhgfs vlkgqaelqm kriwgekekk
     2701 nledginnlk kqwetleplh leaenqikkc dirnkmketi lwaknllgel npsipllpdd
     2761 ilsqirkckv thdgilarqq sveslaeevk dkvpslttye gsdlnntled lrnqyqmlvl
     2821 kstqrsqqle fkleersnff aiirkfqlmv qesetliipr vetaateael khhhvtleas
     2881 qkelqeidsg isthlqeltn iyeelnvfer lfledqlknl kirtnriqrf iqntcneveh
     2941 kikfcrqfhe ktsalqeead siqrnellln qevnkgvkee iynlkdrlta ikccilqvlk
     3001 lkkvfdyigl nwdfsqldql qtqvfekeke leekikqldt feeehgkyqa llskmraidl
     3061 qikkmtevvl kapdsspesr rlnaqilsqr iekakclcde iikklnenkt fddsfkekei
     3121 lqiklnaeen dklykvlqnm vlelspkeld ekncqdklet slhvlnqiks qlqqpllinl
     3181 eikhiqnekd nceafqeqvw aemcsikavt aiekqreens seasdvetkl refedlqmql
     3241 ntsidlrtnv lndayenltr ykeavtrave sitsleaiii pyrvdvgnpe eslemplrkq
     3301 eelestvahi qdlteklgmi sspeaklqlq ytlqelvskn samkeafkaq eteaerylen
     3361 ykcyrkmeed iytnlskmet vlgqsmsslp lsyrealerl eqskalvsnl istkeelmkl
     3421 rqilrllrlr ctendgicll kivsalwekw lslleaakew emwceelkqe wkfvseeier
     3481 eaiildnlqe elpeisktke aatteelsel ldclcqygen vekqqllltl llqrirsiqn
     3541 vpessgavet vpafqeitsm kercnkllqk vqknkelvqt eiqerhsftk eiialknffq
     3601 qtttsfqnma fqdhpekseq feelqsilkk gkltfenime klrikysemy tivpaeiesq
     3661 veecrkaled idekisnevl ksspsyamrr kieeinnglh nvekmlqqks kniekaqeiq
     3721 kkmwdeldlw hsklneldse vqdiveqdpg qaqewmdnlm ipfqqyqqvs qraecrtsql
     3781 nkatvkmeey sdllksteaw ientshllan padydslrtl shhastvqma ledseqkhnl
     3841 lhsifmdled lsiifetdel tqsiqelsnq vtalqqkime slpqiqrmad dvvaiesevk
     3901 smekrvskik tillskeifd fspeehlkhg evilenirpm kktiaeivsy qvelrlpqtg
     3961 mkplpvfqrt nqllqdikll envtqeqnel lkvvikqtne wdeeienlkq ilnnysaqfs
     4021 lehmspdqad klpqlqgeie rmekqilsln qrkedllvdl katvlnlhqh lkqeqegver
     4081 drlpavtsee ggvaerdase rklnrrgsms ylaaveeeve essvksdngd ekaepspqsw
     4141 sslwkhdkdm eedrassssg tivqeaygki stsdnsmaqi ltpdslnteq gpecslrpnq
     4201 teegttppie adtldssdaq ggleprvekt rpeptevlha cktqvaelel wlqqanvave
     4261 petlnadmqq vleqqlvgcq amlteiehkv aflletckdq glgdngatqh eaealslklk
     4321 tvkcnlekvq mmlqekhsed qhptilkkss epehqealqp vnlselesiv terpqfsrqk
     4381 dfqqqqvlel kpmeqkdfik fiefnakkmw pqycqhdndt tqessasnqa sspendvpds
     4441 ilspqgqngd kwqylhhels skiklplpql vepqvstnmg ilpsvtmynf ryptteelkt
     4501 yttqledlrq easnlqtqen mteeayinld kklfelfltl sqclssveem lemprlyred
     4561 gsgqqvhyet lalelkklyl alsdkkgdll kamtwpgent nlllecfdnl qvclehtqaa
     4621 avcrskslka gldynrsyqn eikrlyhqli ksktslqqsl neisgqsvae qlqkadaytv
     4681 elenaesrva klrdegerlh lpyallqevy kledvldsmw gmlrarytel sspfvtesqq
     4741 dallqgmvel vkigkeklah ghlkqtkskv alqaqienhk vffqklvadm lliqaysaki
     4801 lpsllqnret fwaeqvtevk ileeksrqcg mklqsllqkw eefdenyasl ekdleilist
     4861 lpsvslveet eerlverisf yqqikrnigg kharlyqtln egkqlvasvs cpelegqiak
     4921 leeqwlslnk kidhelhrlq allkhllsyn rdsdqltkwl essqhtlnyw keqslnvsqd
     4981 ldtirsninn ffefskevde ksslktavis ignqllhlke tdtatlrasl aqfeqkwtml
     5041 itqlpdiqek lhqlqmeklp srkaitemis wmnnvehqts dedsvhspss asqvkhllqk
     5101 hkefrmemdy kqwivdfvnq sllqlstcdv eskryertef aehlgemnrq whrvhgmlnr
     5161 kiqhleqlle sitesenkiq ilnnwleaqe erlktlqkpe svisvqklll dcqdienqla
     5221 ikskaldelk qsyltlesga vplledtasr idelfqkrss vltqvnqlkt smqsvlqewk
     5281 iydqlydevn mmtirfwycm ehskpvvlsl etlrcqvenl qslqdeaess egsweklqev
     5341 igklkglcps vaeiieekcq nthkrwtqvn qaiadqlqka qsllqlwkay snahgeaaar
     5401 lkqqeakfqq lanismsgnn laeilppalq dikelqhdvq ktkeaflqns svldrlpqpa
     5461 essthmllpg plhslqraay lekmllvkan efefvlsqfk dfgvrleslk glimheeenl
     5521 drlhqqeken pdsflnhvla ltaqspdieh lnevslklpl sdvavktlqn mnrqwirata
     5581 talercselq giglnekfly ccekwiqlle kieealkvdv anslpelleq qktykmleae
     5641 vsinqtiads yvtqslqlld tteienrpef itefskltdr wqnavqgvrq rkgdvdglvr
     5701 qwqdfttsve nlfrfltdts hllsavkgqe rfslyqtrsl ihelknkeih fqrrrttcal
     5761 tleageklll ttdlktkesv grrisqlqds wkdmepqlae mikqfqstve twdqcekkik
     5821 elksrlqvlk aqsedplpel hedlhnekel ikeleqslas wtqnlkelqt mkadltrhvl
     5881 vedvmvlkeq iehlhrqwed lclrvairkq eiedrlntwv vfneknkelc awlvqmenkv
     5941 lqtadisiee mieklqkdcm eeinlfsenk lqlkqmgdql ikasnksraa eiddklnkin
     6001 drwqhlfdvi gsrvkklket fafiqqldkn msnlrtwlar ieselskpvv ydvcddqeiq
     6061 krlaeqqdlq rdieqhsagv esvfnicdvl lhdsdacane tecdsiqqtt rsldrrwrni
     6121 camsmerrmk ieetwrlwqk flddysrfed wlksaertaa cpnssevlyt sakeelkrfe
     6181 afqrqiherl tqlelinkqy rrlarenrtd tasrlkqmvh egnqrwdnlq rrvtavlrrl
     6241 rhftnqreef egtresilvw ltemdlqltn vehfsesdad dkmrqlngfq qeitlntnki
     6301 dqlivfgeql iqksepldav liedeleelh rycqevfgrv srfhrrltsc tpgledekea
     6361 senetdmedp reiqtdswrk rgeseepssp qslchlvapg hersgcetpv svdsiplewd
     6421 htgdvggsss heedeegpyy salsdveipe npeaylkmtt ktlkassgks isdghswhvp
     6481 dspscpehhy kqmegdrnvp pvppasstpy kppygklllp pgtdggkegp rvlngnpqqe
     6541 dgglagiteq qsgtacnwqs sreaeygafd rwemiqaqel hnklkikqnl qqlnsdisai
     6601 ttwlkkteae lemlkmakpp sdiqeielrv krlqeilkaf dtykalvvsv nvsskeflqt
     6661 espestelqs rlrqlsllwe aaqgavdswr gglrqslmqc qgsktrprsd vlffkdfhql
     6721 sqnlllwlas aknrrqkahv tdpkadpral lecrrelmql ekelverqpq vdmlqeisns
     6781 llikghgedc ieaeekvhvi ekklkqlreq vsqdlmalqg tqnpasplps fdevdsgdqp
     6841 patsvpapra kqfravrtte geeetesrvp gstrpqrsfl srvvraalpl qlllllllll
     6901 acllpsseed ysctqannfa rsfypmlryt ngpppt
//
LOCUS       XP_047287106            6936 aa            linear   PRI 05-AUG-2025
DEFINITION  nesprin-2 isoform X1 [Homo sapiens].
ACCESSION   XP_047287106
VERSION     XP_047287106.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431150.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..6936
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..6936
                     /product="nesprin-2 isoform X1"
                     /calculated_mol_wt=802067
     Region          28..138
                     /region_name="CH_SYNE2_rpt1"
                     /note="first calponin homology (CH) domain found in
                     synaptic nuclear envelope protein 2; cd21242"
                     /db_xref="CDD:409091"
     Site            order(33,37,89,91..92,95..96,98,107..115,120,122..123,
                     125..126,129..130,133)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409091"
     Region          178..286
                     /region_name="CH_SYNE2_rpt2"
                     /note="second calponin homology (CH) domain found in
                     synaptic nuclear envelope protein 2 (SYNE-2) and similar
                     proteins; cd21244"
                     /db_xref="CDD:409093"
     Site            order(183,187,237,239..240,243..244,246,255..263,270,
                     272..273,275..276,279..280,283)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409093"
     Region          <1418..2014
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          <1868..>2369
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          <2338..2712
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          2805..>3389
                     /region_name="CCDC158"
                     /note="Coiled-coil domain-containing protein 158;
                     pfam15921"
                     /db_xref="CDD:464943"
     Region          <3656..>3950
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <3811..4113
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <4496..5321
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          4945..5169
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            5054..5059
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5063..5276
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Region          5123..>5875
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Site            5168..5173
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5178..5384
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cl02488"
                     /db_xref="CDD:413338"
     Site            5275..5280
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5919..6133
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6020..6025
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          6137..6350
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6243..6248
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          6590..6813
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6696..6701
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          <6905..6936
                     /region_name="KASH"
                     /note="Nuclear envelope localization domain; pfam10541"
                     /db_xref="CDD:463142"
     CDS             1..6936
                     /gene="SYNE2"
                     /gene_synonym="EDMD5; KASH2; Nesp2; Nesprin-2; NUA;
                     NUANCE; SYNE-2; TROPH"
                     /coded_by="XM_047431150.1:84..20894"
                     /db_xref="GeneID:23224"
                     /db_xref="HGNC:HGNC:17084"
                     /db_xref="MIM:608442"
ORIGIN      
        1 masspelpte deqgswgidd lhislqaeqe dtqkkaftcw insqlarhts psvisdlftd
       61 ikkghvlldl levlsgqqlp rdkgsntfqc riniehaltf lrnrsiklin ihvtdiidgn
      121 psiilgliwt iilhfhiekl aqtlscnynq pslddvsvvd sspassppak kcskvqarwq
      181 msarkalllw aqeqcatyes vnvtdfkssw rngmaflaii halrpdlidm ksvkhrsnkd
      241 nlreafriae qelkiprlle pedvdvvdpd eksimtyvaq flqyskdapg tgeeaqgkvk
      301 damgwltlqk eklqkllkds endtyfkkyn sllsfmesfn eekksfldvl sikrdldeld
      361 kdhlqlreaw dgldhqinaw kiklnyalpp plhqteawlq eveelmdedl sasqdhsqav
      421 tliqekmtlf kslmdrfehh snilltfenk denhlplvpp nkleemkrri nnilekkfil
      481 llefhyykcl vlglvdevks kldiwnikyg sresvellle dwhkfieeke flarldtsfq
      541 kcgeiyknla gecqninkqy mmvksdvcmy rkniynvkst lqkvlacwat yvenlrllra
      601 cfeetkkeei kevpfetlaq wnlehatlne agnflvevsn dvvgssiske lrrlnkrwrk
      661 lvsktqlemn lplmikkqdq ptfdnsgnil skeekatvef stdmsvelpe nynqnikage
      721 khekeneeft gqlkvakdve kligqveiwe aeaksvldqd dvdtsmeesl khliakgsmf
      781 delmarsedm lqmdiqniss qesfqhvltt glqakiqeak ekvqinvvkl iaalknltdv
      841 spdldirlkm eesqkelesy mmraqqllgq respgelisk hkealiisnt kslakylkav
      901 eelknnvted ikmsleeksr dvcakweslh helslyvqql kidiekgkls dnilklekqi
      961 nkekklirrg rtkglikehe acfseegcly qlnhhmevlr elceelpsqk sqqevkrllk
     1021 dyeqkierll kcaseihmtl qptaggtskn egtittsenr ggdphseapf aksdnqpste
     1081 kameptmkfs lasvlrplqe esimekdysa sinslleryd tyrdilehhl qnnkfritsd
     1141 fsseedrsss clqakltdlq viknetdarw kefeiislkl enhvndikkp fvikerdtlk
     1201 ererelqmtl ntrmesleta lrlvlpveka slllcgsdlp lhkmaiqgfh lidadriyqh
     1261 lrniqdsiak qieicnrlee pgnfvlkelh pfdlhamqni ilkyktqfeg mnhrvqrsed
     1321 tlkaledfla slrtaklsae pvtdlsasdt qvaqentltv knkegeihlm kdkakhldkc
     1381 lkmldmsfkd aergddtsce nlldafsikl sethgygvqe efteenklle acifknnell
     1441 kniqdvqsqi skiglkdptv pavkhrkksl irldkvldey eeekrhlqem anslphfkdg
     1501 rektvnqqcq ntvvlwentk alvtecleqc grvlellkqy qnfksilttl iqkeesvisl
     1561 qasymgkenl kkriaeieiv keefnehlev vdkinqvckn lqfylnkmkt feeppfekea
     1621 niivdrwldi nektedyyen lgralalwdk lfnlknvide wtekalqkme lhqlteedre
     1681 rlkeelqvhe qktsefsrrv aeiqfllqss eiplelqvme ssilnkmehv qkcltgesnc
     1741 halsgstael redldqaktq igmtesllka lspsdsleif tkleeiqqqi lqqkhsmill
     1801 enqigcltpe lselkkqyes vsdlfntkks vlqdhfskll ndqcknfndw fsnikvnlke
     1861 cfessetkks veqklqklsd fltlegrnsk ikqvdsvlkh vkkhlpkahv keliswlvgq
     1921 efelekmesi cqarakeled slqqllrlqd dhrnlrkwlt nqeekwkgme epgektelfc
     1981 qalarkreqf esvaqlnnsl keygfteeee iimeatclmd ryqtllrqls eieeedkllp
     2041 tedqsfndla hdvihwikei keslmvlnss egkmpleeri qkikeiillk pegdarieti
     2101 mkqaesseap lvqktltdis nqwdntlhla stylshqekl llegekylqs kedlrlmlie
     2161 lkkkqeagfa lqhglqekka qlkiykkflk kaqdltsllk elksqgnyll ectknpsfse
     2221 epwleikhlh esllqqlqds vqnldghvre hdsyqvcvtd lnttldnfsk efvsfsdkpv
     2281 dqiaveeklq klqelenrls lqdgtlkkil alaksvkqnt ssvgqkiikd dikslqckqk
     2341 dlenrlasak qemecclnsi lkskrstekk gkftlpgrek qatsdvqest qesaavekle
     2401 edweinkdsa vemamskqls lnaqesmknt ederkvnelq nqpleldtml rneqleeiek
     2461 lytqleakka aikpleqtec lnktetgalv lhnigysaqh ldnllqalit lkknkesqyc
     2521 vlrdfqeyla avessmkall tdkeslkvgp ldsvtyldki kkfiasieke kdslgnlkik
     2581 wenlsnhvtd mdkkllesqi kqlehgweqv eqqiqkkysq qvveydeftt lmnkvqdtei
     2641 slqqqqqhlq lrlkspeera gnqsmialtt dlqatkhgfs vlkgqaelqm kriwgekekk
     2701 nledginnlk kqwetleplh leaenqikkc dirnkmketi lwaknllgel npsipllpdd
     2761 ilsqirkckv thdgilarqq sveslaeevk dkvpslttye gsdlnntled lrnqyqmlvl
     2821 kstqrsqqle fkleersnff aiirkfqlmv qesetliipr vetaateael khhhvtleas
     2881 qkelqeidsg isthlqeltn iyeelnvfer lfledqlknl kirtnriqrf iqntcneveh
     2941 kikfcrqfhe ktsalqeead siqrnellln qevnkgvkee iynlkdrlta ikccilqvlk
     3001 lkkvfdyigl nwdfsqldql qtqvfekeke leekikqldt feeehgkyqa llskmraidl
     3061 qikkmtevvl kapdsspesr rlnaqilsqr iekakclcde iikklnenkt fddsfkekei
     3121 lqiklnaeen dklykvlqnm vlelspkeld ekncqdklet slhvlnqiks qlqqpllinl
     3181 eikhiqnekd nceafqeqvw aemcsikavt aiekqreens seasdvetkl refedlqmql
     3241 ntsidlrtnv lndayenltr ykeavtrave sitsleaiii pyrvdvgnpe eslemplrkq
     3301 eelestvahi qdlteklgmi sspeaklqlq ytlqelvskn samkeafkaq eteaerylen
     3361 ykcyrkmeed iytnlskmet vlgqsmsslp lsyrealerl eqskalvsnl istkeelmkl
     3421 rqilrllrlr ctendgicll kivsalwekw lslleaakew emwceelkqe wkfvseeier
     3481 eaiildnlqe elpeisktke aatteelsel ldclcqygen vekqqllltl llqrirsiqn
     3541 vpessgavet vpafqeitsm kercnkllqk vqknkelvqt eiqerhsftk eiialknffq
     3601 qtttsfqnma fqdhpekseq feelqsilkk gkltfenime klrikysemy tivpaeiesq
     3661 veecrkaled idekisnevl ksspsyamrr kieeinnglh nvekmlqqks kniekaqeiq
     3721 kkmwdeldlw hsklneldse vqdiveqdpg qaqewmdnlm ipfqqyqqvs qraecrtsql
     3781 nkatvkmeey sdllksteaw ientshllan padydslrtl shhastvqma ledseqkhnl
     3841 lhsifmdled lsiifetdel tqsiqelsnq vtalqqkime slpqiqrmad dvvaiesevk
     3901 smekrvskik tillskeifd fspeehlkhg evilenirpm kktiaeivsy qvelrlpqtg
     3961 mkplpvfqrt nqllqdikll envtqeqnel lkvvikqtne wdeeienlkq ilnnysaqfs
     4021 lehmspdqad klpqlqgeie rmekqilsln qrkedllvdl katvlnlhqh lkqeqegver
     4081 drlpavtsee ggvaerdase rklnrrgsms ylaaveeeve essvksdngd ekaepspqsw
     4141 sslwkhdkdm eedrassssg tivqeaygki stsdnsmaqi ltpdslnteq gpecslrpnq
     4201 teegttppie adtldssdaq ggleprvekt rpeptevlha cktqvaelel wlqqanvave
     4261 petlnadmqq vleqqlvgcq amlteiehkv aflletckdq glgdngatqh eaealslklk
     4321 tvkcnlekvq mmlqekhsed qhptilkkss epehqealqp vnlselesiv terpqfsrqk
     4381 dfqqqqvlel kpmeqkdfik fiefnakkmw pqycqhdndt tqessasnqa sspendvpds
     4441 ilspqgqngd kwqylhhels skiklplpql vepqvstnmg ilpsvtmynf ryptteelkt
     4501 yttqledlrq easnlqtqen mteeayinld kklfelfltl sqclssveem lemprlyred
     4561 gsgqqvhyet lalelkklyl alsdkkgdll kamtwpgent nlllecfdnl qvclehtqaa
     4621 avcrskslka gldynrsyqn eikrlyhqli ksktslqqsl neisgqsvae qlqkadaytv
     4681 elenaesrva klrdegerlh lpyallqevy kledvldsmw gmlrarytel sspfvtesqq
     4741 dallqgmvel vkigkeklah ghlkqtkskv alqaqienhk vffqklvadm lliqaysaki
     4801 lpsllqnret fwaeqvtevk ileeksrqcg mklqsllqkw eefdenyasl ekdleilist
     4861 lpsvslveet eerlverisf yqqikrnigg kharlyqtln egkqlvasvs cpelegqiak
     4921 leeqwlslnk kidhelhrlq allkhllsyn rdsdqltkwl essqhtlnyw keqslnvsqd
     4981 ldtirsninn ffefskevde ksslktavis ignqllhlke tdtatlrasl aqfeqkwtml
     5041 itqlpdiqek lhqlqmeklp srkaitemis wmnnvehqts dedsvhspss asqvkhllqk
     5101 hkefrmemdy kqwivdfvnq sllqlstcdv eskryertef aehlgemnrq whrvhgmlnr
     5161 kiqhleqlle sitesenkiq ilnnwleaqe erlktlqkpe svisvqklll dcqdienqla
     5221 ikskaldelk qsyltlesga vplledtasr idelfqkrss vltqvnqlkt smqsvlqewk
     5281 iydqlydevn mmtirfwycm ehskpvvlsl etlrcqvenl qslqdeaess egsweklqev
     5341 igklkglcps vaeiieekcq nthkrwtqvn qaiadqlqka qsllqlwkay snahgeaaar
     5401 lkqqeakfqq lanismsgnn laeilppalq dikelqhdvq ktkeaflqns svldrlpqpa
     5461 essthmllpg plhslqraay lekmllvkan efefvlsqfk dfgvrleslk glimheeenl
     5521 drlhqqeken pdsflnhvla ltaqspdieh lnevslklpl sdvavktlqn mnrqwirata
     5581 talercselq giglnekfly ccekwiqlle kieealkvdv anslpelleq qktykmleae
     5641 vsinqtiads yvtqslqlld tteienrpef itefskltdr wqnavqgvrq rkgdvdglvr
     5701 qwqdfttsve nlfrfltdts hllsavkgqe rfslyqtrsl ihelknkeih fqrrrttcal
     5761 tleageklll ttdlktkesv grrisqlqds wkdmepqlae mikqfqstve twdqcekkik
     5821 elksrlqvlk aqsedplpel hedlhnekel ikeleqslas wtqnlkelqt mkadltrhvl
     5881 vedvmvlkeq iehlhrqwed lclrvairkq eiedrlntwv vfneknkelc awlvqmenkv
     5941 lqtadisiee mieklqkdcm eeinlfsenk lqlkqmgdql ikasnksraa eiddklnkin
     6001 drwqhlfdvi gsrvkklket fafiqqldkn msnlrtwlar ieselskpvv ydvcddqeiq
     6061 krlaeqqdlq rdieqhsagv esvfnicdvl lhdsdacane tecdsiqqtt rsldrrwrni
     6121 camsmerrmk ieetwrlwqk flddysrfed wlksaertaa cpnssevlyt sakeelkrfe
     6181 afqrqiherl tqlelinkqy rrlarenrtd tasrlkqmvh egnqrwdnlq rrvtavlrrl
     6241 rhftnqreef egtresilvw ltemdlqltn vehfsesdad dkmrqlngfq qeitlntnki
     6301 dqlivfgeql iqksepldav liedeleelh rycqevfgrv srfhrrltsc tpgledekea
     6361 senetdmedp reiqtdswrk rgeseepssp qslchlvapg hersgcetpv svdsiplewd
     6421 htgdvggsss heedeegpyy salsdveipe npeaylkmtt ktlkassgks isdghswhvp
     6481 dspscpehhy kqmegdrnvp pvppasstpy kppygklllp pgtdggkegp rvlngnpqqe
     6541 dgglagiteq qsgtacnwqs sreaeygafd rwemiqaqel hnklkikqnl qqlnsdisai
     6601 ttwlkkteae lemlkmakpp sdiqeielrv krlqeilkaf dtykalvvsv nvsskeflqt
     6661 espestelqs rlrqlsllwe aaqgavdswr gglrqslmqc qgsktrprsd vlffkdfhql
     6721 sqnlllwlas aknrrqkahv tdpkadpral lecrrelmql ekelverqpq vdmlqeisns
     6781 llikghgedc ieaeekvhvi ekklkqlreq vsqdlmalqg tqnpasplps fdevdsgdqp
     6841 patsvpapra kqfravrtte geeetesrvp gstrpqrsfl srvvraalpl qlllllllll
     6901 acllpsseed ysctqannfa rsfypmlryt ngpppt
//
LOCUS       XP_047287107            6936 aa            linear   PRI 05-AUG-2025
DEFINITION  nesprin-2 isoform X1 [Homo sapiens].
ACCESSION   XP_047287107
VERSION     XP_047287107.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431151.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..6936
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..6936
                     /product="nesprin-2 isoform X1"
                     /calculated_mol_wt=802067
     Region          28..138
                     /region_name="CH_SYNE2_rpt1"
                     /note="first calponin homology (CH) domain found in
                     synaptic nuclear envelope protein 2; cd21242"
                     /db_xref="CDD:409091"
     Site            order(33,37,89,91..92,95..96,98,107..115,120,122..123,
                     125..126,129..130,133)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409091"
     Region          178..286
                     /region_name="CH_SYNE2_rpt2"
                     /note="second calponin homology (CH) domain found in
                     synaptic nuclear envelope protein 2 (SYNE-2) and similar
                     proteins; cd21244"
                     /db_xref="CDD:409093"
     Site            order(183,187,237,239..240,243..244,246,255..263,270,
                     272..273,275..276,279..280,283)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409093"
     Region          <1418..2014
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          <1868..>2369
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          <2338..2712
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          2805..>3389
                     /region_name="CCDC158"
                     /note="Coiled-coil domain-containing protein 158;
                     pfam15921"
                     /db_xref="CDD:464943"
     Region          <3656..>3950
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <3811..4113
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <4496..5321
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          4945..5169
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            5054..5059
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5063..5276
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Region          5123..>5875
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Site            5168..5173
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5178..5384
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cl02488"
                     /db_xref="CDD:413338"
     Site            5275..5280
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5919..6133
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6020..6025
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          6137..6350
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6243..6248
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          6590..6813
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6696..6701
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          <6905..6936
                     /region_name="KASH"
                     /note="Nuclear envelope localization domain; pfam10541"
                     /db_xref="CDD:463142"
     CDS             1..6936
                     /gene="SYNE2"
                     /gene_synonym="EDMD5; KASH2; Nesp2; Nesprin-2; NUA;
                     NUANCE; SYNE-2; TROPH"
                     /coded_by="XM_047431151.1:136..20946"
                     /db_xref="GeneID:23224"
                     /db_xref="HGNC:HGNC:17084"
                     /db_xref="MIM:608442"
ORIGIN      
        1 masspelpte deqgswgidd lhislqaeqe dtqkkaftcw insqlarhts psvisdlftd
       61 ikkghvlldl levlsgqqlp rdkgsntfqc riniehaltf lrnrsiklin ihvtdiidgn
      121 psiilgliwt iilhfhiekl aqtlscnynq pslddvsvvd sspassppak kcskvqarwq
      181 msarkalllw aqeqcatyes vnvtdfkssw rngmaflaii halrpdlidm ksvkhrsnkd
      241 nlreafriae qelkiprlle pedvdvvdpd eksimtyvaq flqyskdapg tgeeaqgkvk
      301 damgwltlqk eklqkllkds endtyfkkyn sllsfmesfn eekksfldvl sikrdldeld
      361 kdhlqlreaw dgldhqinaw kiklnyalpp plhqteawlq eveelmdedl sasqdhsqav
      421 tliqekmtlf kslmdrfehh snilltfenk denhlplvpp nkleemkrri nnilekkfil
      481 llefhyykcl vlglvdevks kldiwnikyg sresvellle dwhkfieeke flarldtsfq
      541 kcgeiyknla gecqninkqy mmvksdvcmy rkniynvkst lqkvlacwat yvenlrllra
      601 cfeetkkeei kevpfetlaq wnlehatlne agnflvevsn dvvgssiske lrrlnkrwrk
      661 lvsktqlemn lplmikkqdq ptfdnsgnil skeekatvef stdmsvelpe nynqnikage
      721 khekeneeft gqlkvakdve kligqveiwe aeaksvldqd dvdtsmeesl khliakgsmf
      781 delmarsedm lqmdiqniss qesfqhvltt glqakiqeak ekvqinvvkl iaalknltdv
      841 spdldirlkm eesqkelesy mmraqqllgq respgelisk hkealiisnt kslakylkav
      901 eelknnvted ikmsleeksr dvcakweslh helslyvqql kidiekgkls dnilklekqi
      961 nkekklirrg rtkglikehe acfseegcly qlnhhmevlr elceelpsqk sqqevkrllk
     1021 dyeqkierll kcaseihmtl qptaggtskn egtittsenr ggdphseapf aksdnqpste
     1081 kameptmkfs lasvlrplqe esimekdysa sinslleryd tyrdilehhl qnnkfritsd
     1141 fsseedrsss clqakltdlq viknetdarw kefeiislkl enhvndikkp fvikerdtlk
     1201 ererelqmtl ntrmesleta lrlvlpveka slllcgsdlp lhkmaiqgfh lidadriyqh
     1261 lrniqdsiak qieicnrlee pgnfvlkelh pfdlhamqni ilkyktqfeg mnhrvqrsed
     1321 tlkaledfla slrtaklsae pvtdlsasdt qvaqentltv knkegeihlm kdkakhldkc
     1381 lkmldmsfkd aergddtsce nlldafsikl sethgygvqe efteenklle acifknnell
     1441 kniqdvqsqi skiglkdptv pavkhrkksl irldkvldey eeekrhlqem anslphfkdg
     1501 rektvnqqcq ntvvlwentk alvtecleqc grvlellkqy qnfksilttl iqkeesvisl
     1561 qasymgkenl kkriaeieiv keefnehlev vdkinqvckn lqfylnkmkt feeppfekea
     1621 niivdrwldi nektedyyen lgralalwdk lfnlknvide wtekalqkme lhqlteedre
     1681 rlkeelqvhe qktsefsrrv aeiqfllqss eiplelqvme ssilnkmehv qkcltgesnc
     1741 halsgstael redldqaktq igmtesllka lspsdsleif tkleeiqqqi lqqkhsmill
     1801 enqigcltpe lselkkqyes vsdlfntkks vlqdhfskll ndqcknfndw fsnikvnlke
     1861 cfessetkks veqklqklsd fltlegrnsk ikqvdsvlkh vkkhlpkahv keliswlvgq
     1921 efelekmesi cqarakeled slqqllrlqd dhrnlrkwlt nqeekwkgme epgektelfc
     1981 qalarkreqf esvaqlnnsl keygfteeee iimeatclmd ryqtllrqls eieeedkllp
     2041 tedqsfndla hdvihwikei keslmvlnss egkmpleeri qkikeiillk pegdarieti
     2101 mkqaesseap lvqktltdis nqwdntlhla stylshqekl llegekylqs kedlrlmlie
     2161 lkkkqeagfa lqhglqekka qlkiykkflk kaqdltsllk elksqgnyll ectknpsfse
     2221 epwleikhlh esllqqlqds vqnldghvre hdsyqvcvtd lnttldnfsk efvsfsdkpv
     2281 dqiaveeklq klqelenrls lqdgtlkkil alaksvkqnt ssvgqkiikd dikslqckqk
     2341 dlenrlasak qemecclnsi lkskrstekk gkftlpgrek qatsdvqest qesaavekle
     2401 edweinkdsa vemamskqls lnaqesmknt ederkvnelq nqpleldtml rneqleeiek
     2461 lytqleakka aikpleqtec lnktetgalv lhnigysaqh ldnllqalit lkknkesqyc
     2521 vlrdfqeyla avessmkall tdkeslkvgp ldsvtyldki kkfiasieke kdslgnlkik
     2581 wenlsnhvtd mdkkllesqi kqlehgweqv eqqiqkkysq qvveydeftt lmnkvqdtei
     2641 slqqqqqhlq lrlkspeera gnqsmialtt dlqatkhgfs vlkgqaelqm kriwgekekk
     2701 nledginnlk kqwetleplh leaenqikkc dirnkmketi lwaknllgel npsipllpdd
     2761 ilsqirkckv thdgilarqq sveslaeevk dkvpslttye gsdlnntled lrnqyqmlvl
     2821 kstqrsqqle fkleersnff aiirkfqlmv qesetliipr vetaateael khhhvtleas
     2881 qkelqeidsg isthlqeltn iyeelnvfer lfledqlknl kirtnriqrf iqntcneveh
     2941 kikfcrqfhe ktsalqeead siqrnellln qevnkgvkee iynlkdrlta ikccilqvlk
     3001 lkkvfdyigl nwdfsqldql qtqvfekeke leekikqldt feeehgkyqa llskmraidl
     3061 qikkmtevvl kapdsspesr rlnaqilsqr iekakclcde iikklnenkt fddsfkekei
     3121 lqiklnaeen dklykvlqnm vlelspkeld ekncqdklet slhvlnqiks qlqqpllinl
     3181 eikhiqnekd nceafqeqvw aemcsikavt aiekqreens seasdvetkl refedlqmql
     3241 ntsidlrtnv lndayenltr ykeavtrave sitsleaiii pyrvdvgnpe eslemplrkq
     3301 eelestvahi qdlteklgmi sspeaklqlq ytlqelvskn samkeafkaq eteaerylen
     3361 ykcyrkmeed iytnlskmet vlgqsmsslp lsyrealerl eqskalvsnl istkeelmkl
     3421 rqilrllrlr ctendgicll kivsalwekw lslleaakew emwceelkqe wkfvseeier
     3481 eaiildnlqe elpeisktke aatteelsel ldclcqygen vekqqllltl llqrirsiqn
     3541 vpessgavet vpafqeitsm kercnkllqk vqknkelvqt eiqerhsftk eiialknffq
     3601 qtttsfqnma fqdhpekseq feelqsilkk gkltfenime klrikysemy tivpaeiesq
     3661 veecrkaled idekisnevl ksspsyamrr kieeinnglh nvekmlqqks kniekaqeiq
     3721 kkmwdeldlw hsklneldse vqdiveqdpg qaqewmdnlm ipfqqyqqvs qraecrtsql
     3781 nkatvkmeey sdllksteaw ientshllan padydslrtl shhastvqma ledseqkhnl
     3841 lhsifmdled lsiifetdel tqsiqelsnq vtalqqkime slpqiqrmad dvvaiesevk
     3901 smekrvskik tillskeifd fspeehlkhg evilenirpm kktiaeivsy qvelrlpqtg
     3961 mkplpvfqrt nqllqdikll envtqeqnel lkvvikqtne wdeeienlkq ilnnysaqfs
     4021 lehmspdqad klpqlqgeie rmekqilsln qrkedllvdl katvlnlhqh lkqeqegver
     4081 drlpavtsee ggvaerdase rklnrrgsms ylaaveeeve essvksdngd ekaepspqsw
     4141 sslwkhdkdm eedrassssg tivqeaygki stsdnsmaqi ltpdslnteq gpecslrpnq
     4201 teegttppie adtldssdaq ggleprvekt rpeptevlha cktqvaelel wlqqanvave
     4261 petlnadmqq vleqqlvgcq amlteiehkv aflletckdq glgdngatqh eaealslklk
     4321 tvkcnlekvq mmlqekhsed qhptilkkss epehqealqp vnlselesiv terpqfsrqk
     4381 dfqqqqvlel kpmeqkdfik fiefnakkmw pqycqhdndt tqessasnqa sspendvpds
     4441 ilspqgqngd kwqylhhels skiklplpql vepqvstnmg ilpsvtmynf ryptteelkt
     4501 yttqledlrq easnlqtqen mteeayinld kklfelfltl sqclssveem lemprlyred
     4561 gsgqqvhyet lalelkklyl alsdkkgdll kamtwpgent nlllecfdnl qvclehtqaa
     4621 avcrskslka gldynrsyqn eikrlyhqli ksktslqqsl neisgqsvae qlqkadaytv
     4681 elenaesrva klrdegerlh lpyallqevy kledvldsmw gmlrarytel sspfvtesqq
     4741 dallqgmvel vkigkeklah ghlkqtkskv alqaqienhk vffqklvadm lliqaysaki
     4801 lpsllqnret fwaeqvtevk ileeksrqcg mklqsllqkw eefdenyasl ekdleilist
     4861 lpsvslveet eerlverisf yqqikrnigg kharlyqtln egkqlvasvs cpelegqiak
     4921 leeqwlslnk kidhelhrlq allkhllsyn rdsdqltkwl essqhtlnyw keqslnvsqd
     4981 ldtirsninn ffefskevde ksslktavis ignqllhlke tdtatlrasl aqfeqkwtml
     5041 itqlpdiqek lhqlqmeklp srkaitemis wmnnvehqts dedsvhspss asqvkhllqk
     5101 hkefrmemdy kqwivdfvnq sllqlstcdv eskryertef aehlgemnrq whrvhgmlnr
     5161 kiqhleqlle sitesenkiq ilnnwleaqe erlktlqkpe svisvqklll dcqdienqla
     5221 ikskaldelk qsyltlesga vplledtasr idelfqkrss vltqvnqlkt smqsvlqewk
     5281 iydqlydevn mmtirfwycm ehskpvvlsl etlrcqvenl qslqdeaess egsweklqev
     5341 igklkglcps vaeiieekcq nthkrwtqvn qaiadqlqka qsllqlwkay snahgeaaar
     5401 lkqqeakfqq lanismsgnn laeilppalq dikelqhdvq ktkeaflqns svldrlpqpa
     5461 essthmllpg plhslqraay lekmllvkan efefvlsqfk dfgvrleslk glimheeenl
     5521 drlhqqeken pdsflnhvla ltaqspdieh lnevslklpl sdvavktlqn mnrqwirata
     5581 talercselq giglnekfly ccekwiqlle kieealkvdv anslpelleq qktykmleae
     5641 vsinqtiads yvtqslqlld tteienrpef itefskltdr wqnavqgvrq rkgdvdglvr
     5701 qwqdfttsve nlfrfltdts hllsavkgqe rfslyqtrsl ihelknkeih fqrrrttcal
     5761 tleageklll ttdlktkesv grrisqlqds wkdmepqlae mikqfqstve twdqcekkik
     5821 elksrlqvlk aqsedplpel hedlhnekel ikeleqslas wtqnlkelqt mkadltrhvl
     5881 vedvmvlkeq iehlhrqwed lclrvairkq eiedrlntwv vfneknkelc awlvqmenkv
     5941 lqtadisiee mieklqkdcm eeinlfsenk lqlkqmgdql ikasnksraa eiddklnkin
     6001 drwqhlfdvi gsrvkklket fafiqqldkn msnlrtwlar ieselskpvv ydvcddqeiq
     6061 krlaeqqdlq rdieqhsagv esvfnicdvl lhdsdacane tecdsiqqtt rsldrrwrni
     6121 camsmerrmk ieetwrlwqk flddysrfed wlksaertaa cpnssevlyt sakeelkrfe
     6181 afqrqiherl tqlelinkqy rrlarenrtd tasrlkqmvh egnqrwdnlq rrvtavlrrl
     6241 rhftnqreef egtresilvw ltemdlqltn vehfsesdad dkmrqlngfq qeitlntnki
     6301 dqlivfgeql iqksepldav liedeleelh rycqevfgrv srfhrrltsc tpgledekea
     6361 senetdmedp reiqtdswrk rgeseepssp qslchlvapg hersgcetpv svdsiplewd
     6421 htgdvggsss heedeegpyy salsdveipe npeaylkmtt ktlkassgks isdghswhvp
     6481 dspscpehhy kqmegdrnvp pvppasstpy kppygklllp pgtdggkegp rvlngnpqqe
     6541 dgglagiteq qsgtacnwqs sreaeygafd rwemiqaqel hnklkikqnl qqlnsdisai
     6601 ttwlkkteae lemlkmakpp sdiqeielrv krlqeilkaf dtykalvvsv nvsskeflqt
     6661 espestelqs rlrqlsllwe aaqgavdswr gglrqslmqc qgsktrprsd vlffkdfhql
     6721 sqnlllwlas aknrrqkahv tdpkadpral lecrrelmql ekelverqpq vdmlqeisns
     6781 llikghgedc ieaeekvhvi ekklkqlreq vsqdlmalqg tqnpasplps fdevdsgdqp
     6841 patsvpapra kqfravrtte geeetesrvp gstrpqrsfl srvvraalpl qlllllllll
     6901 acllpsseed ysctqannfa rsfypmlryt ngpppt
//
LOCUS       XP_047287108            6936 aa            linear   PRI 05-AUG-2025
DEFINITION  nesprin-2 isoform X1 [Homo sapiens].
ACCESSION   XP_047287108
VERSION     XP_047287108.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431152.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..6936
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..6936
                     /product="nesprin-2 isoform X1"
                     /calculated_mol_wt=802067
     Region          28..138
                     /region_name="CH_SYNE2_rpt1"
                     /note="first calponin homology (CH) domain found in
                     synaptic nuclear envelope protein 2; cd21242"
                     /db_xref="CDD:409091"
     Site            order(33,37,89,91..92,95..96,98,107..115,120,122..123,
                     125..126,129..130,133)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409091"
     Region          178..286
                     /region_name="CH_SYNE2_rpt2"
                     /note="second calponin homology (CH) domain found in
                     synaptic nuclear envelope protein 2 (SYNE-2) and similar
                     proteins; cd21244"
                     /db_xref="CDD:409093"
     Site            order(183,187,237,239..240,243..244,246,255..263,270,
                     272..273,275..276,279..280,283)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409093"
     Region          <1418..2014
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          <1868..>2369
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          <2338..2712
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          2805..>3389
                     /region_name="CCDC158"
                     /note="Coiled-coil domain-containing protein 158;
                     pfam15921"
                     /db_xref="CDD:464943"
     Region          <3656..>3950
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <3811..4113
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <4496..5321
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          4945..5169
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            5054..5059
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5063..5276
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Region          5123..>5875
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Site            5168..5173
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5178..5384
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cl02488"
                     /db_xref="CDD:413338"
     Site            5275..5280
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5919..6133
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6020..6025
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          6137..6350
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6243..6248
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          6590..6813
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6696..6701
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          <6905..6936
                     /region_name="KASH"
                     /note="Nuclear envelope localization domain; pfam10541"
                     /db_xref="CDD:463142"
     CDS             1..6936
                     /gene="SYNE2"
                     /gene_synonym="EDMD5; KASH2; Nesp2; Nesprin-2; NUA;
                     NUANCE; SYNE-2; TROPH"
                     /coded_by="XM_047431152.1:439..21249"
                     /db_xref="GeneID:23224"
                     /db_xref="HGNC:HGNC:17084"
                     /db_xref="MIM:608442"
ORIGIN      
        1 masspelpte deqgswgidd lhislqaeqe dtqkkaftcw insqlarhts psvisdlftd
       61 ikkghvlldl levlsgqqlp rdkgsntfqc riniehaltf lrnrsiklin ihvtdiidgn
      121 psiilgliwt iilhfhiekl aqtlscnynq pslddvsvvd sspassppak kcskvqarwq
      181 msarkalllw aqeqcatyes vnvtdfkssw rngmaflaii halrpdlidm ksvkhrsnkd
      241 nlreafriae qelkiprlle pedvdvvdpd eksimtyvaq flqyskdapg tgeeaqgkvk
      301 damgwltlqk eklqkllkds endtyfkkyn sllsfmesfn eekksfldvl sikrdldeld
      361 kdhlqlreaw dgldhqinaw kiklnyalpp plhqteawlq eveelmdedl sasqdhsqav
      421 tliqekmtlf kslmdrfehh snilltfenk denhlplvpp nkleemkrri nnilekkfil
      481 llefhyykcl vlglvdevks kldiwnikyg sresvellle dwhkfieeke flarldtsfq
      541 kcgeiyknla gecqninkqy mmvksdvcmy rkniynvkst lqkvlacwat yvenlrllra
      601 cfeetkkeei kevpfetlaq wnlehatlne agnflvevsn dvvgssiske lrrlnkrwrk
      661 lvsktqlemn lplmikkqdq ptfdnsgnil skeekatvef stdmsvelpe nynqnikage
      721 khekeneeft gqlkvakdve kligqveiwe aeaksvldqd dvdtsmeesl khliakgsmf
      781 delmarsedm lqmdiqniss qesfqhvltt glqakiqeak ekvqinvvkl iaalknltdv
      841 spdldirlkm eesqkelesy mmraqqllgq respgelisk hkealiisnt kslakylkav
      901 eelknnvted ikmsleeksr dvcakweslh helslyvqql kidiekgkls dnilklekqi
      961 nkekklirrg rtkglikehe acfseegcly qlnhhmevlr elceelpsqk sqqevkrllk
     1021 dyeqkierll kcaseihmtl qptaggtskn egtittsenr ggdphseapf aksdnqpste
     1081 kameptmkfs lasvlrplqe esimekdysa sinslleryd tyrdilehhl qnnkfritsd
     1141 fsseedrsss clqakltdlq viknetdarw kefeiislkl enhvndikkp fvikerdtlk
     1201 ererelqmtl ntrmesleta lrlvlpveka slllcgsdlp lhkmaiqgfh lidadriyqh
     1261 lrniqdsiak qieicnrlee pgnfvlkelh pfdlhamqni ilkyktqfeg mnhrvqrsed
     1321 tlkaledfla slrtaklsae pvtdlsasdt qvaqentltv knkegeihlm kdkakhldkc
     1381 lkmldmsfkd aergddtsce nlldafsikl sethgygvqe efteenklle acifknnell
     1441 kniqdvqsqi skiglkdptv pavkhrkksl irldkvldey eeekrhlqem anslphfkdg
     1501 rektvnqqcq ntvvlwentk alvtecleqc grvlellkqy qnfksilttl iqkeesvisl
     1561 qasymgkenl kkriaeieiv keefnehlev vdkinqvckn lqfylnkmkt feeppfekea
     1621 niivdrwldi nektedyyen lgralalwdk lfnlknvide wtekalqkme lhqlteedre
     1681 rlkeelqvhe qktsefsrrv aeiqfllqss eiplelqvme ssilnkmehv qkcltgesnc
     1741 halsgstael redldqaktq igmtesllka lspsdsleif tkleeiqqqi lqqkhsmill
     1801 enqigcltpe lselkkqyes vsdlfntkks vlqdhfskll ndqcknfndw fsnikvnlke
     1861 cfessetkks veqklqklsd fltlegrnsk ikqvdsvlkh vkkhlpkahv keliswlvgq
     1921 efelekmesi cqarakeled slqqllrlqd dhrnlrkwlt nqeekwkgme epgektelfc
     1981 qalarkreqf esvaqlnnsl keygfteeee iimeatclmd ryqtllrqls eieeedkllp
     2041 tedqsfndla hdvihwikei keslmvlnss egkmpleeri qkikeiillk pegdarieti
     2101 mkqaesseap lvqktltdis nqwdntlhla stylshqekl llegekylqs kedlrlmlie
     2161 lkkkqeagfa lqhglqekka qlkiykkflk kaqdltsllk elksqgnyll ectknpsfse
     2221 epwleikhlh esllqqlqds vqnldghvre hdsyqvcvtd lnttldnfsk efvsfsdkpv
     2281 dqiaveeklq klqelenrls lqdgtlkkil alaksvkqnt ssvgqkiikd dikslqckqk
     2341 dlenrlasak qemecclnsi lkskrstekk gkftlpgrek qatsdvqest qesaavekle
     2401 edweinkdsa vemamskqls lnaqesmknt ederkvnelq nqpleldtml rneqleeiek
     2461 lytqleakka aikpleqtec lnktetgalv lhnigysaqh ldnllqalit lkknkesqyc
     2521 vlrdfqeyla avessmkall tdkeslkvgp ldsvtyldki kkfiasieke kdslgnlkik
     2581 wenlsnhvtd mdkkllesqi kqlehgweqv eqqiqkkysq qvveydeftt lmnkvqdtei
     2641 slqqqqqhlq lrlkspeera gnqsmialtt dlqatkhgfs vlkgqaelqm kriwgekekk
     2701 nledginnlk kqwetleplh leaenqikkc dirnkmketi lwaknllgel npsipllpdd
     2761 ilsqirkckv thdgilarqq sveslaeevk dkvpslttye gsdlnntled lrnqyqmlvl
     2821 kstqrsqqle fkleersnff aiirkfqlmv qesetliipr vetaateael khhhvtleas
     2881 qkelqeidsg isthlqeltn iyeelnvfer lfledqlknl kirtnriqrf iqntcneveh
     2941 kikfcrqfhe ktsalqeead siqrnellln qevnkgvkee iynlkdrlta ikccilqvlk
     3001 lkkvfdyigl nwdfsqldql qtqvfekeke leekikqldt feeehgkyqa llskmraidl
     3061 qikkmtevvl kapdsspesr rlnaqilsqr iekakclcde iikklnenkt fddsfkekei
     3121 lqiklnaeen dklykvlqnm vlelspkeld ekncqdklet slhvlnqiks qlqqpllinl
     3181 eikhiqnekd nceafqeqvw aemcsikavt aiekqreens seasdvetkl refedlqmql
     3241 ntsidlrtnv lndayenltr ykeavtrave sitsleaiii pyrvdvgnpe eslemplrkq
     3301 eelestvahi qdlteklgmi sspeaklqlq ytlqelvskn samkeafkaq eteaerylen
     3361 ykcyrkmeed iytnlskmet vlgqsmsslp lsyrealerl eqskalvsnl istkeelmkl
     3421 rqilrllrlr ctendgicll kivsalwekw lslleaakew emwceelkqe wkfvseeier
     3481 eaiildnlqe elpeisktke aatteelsel ldclcqygen vekqqllltl llqrirsiqn
     3541 vpessgavet vpafqeitsm kercnkllqk vqknkelvqt eiqerhsftk eiialknffq
     3601 qtttsfqnma fqdhpekseq feelqsilkk gkltfenime klrikysemy tivpaeiesq
     3661 veecrkaled idekisnevl ksspsyamrr kieeinnglh nvekmlqqks kniekaqeiq
     3721 kkmwdeldlw hsklneldse vqdiveqdpg qaqewmdnlm ipfqqyqqvs qraecrtsql
     3781 nkatvkmeey sdllksteaw ientshllan padydslrtl shhastvqma ledseqkhnl
     3841 lhsifmdled lsiifetdel tqsiqelsnq vtalqqkime slpqiqrmad dvvaiesevk
     3901 smekrvskik tillskeifd fspeehlkhg evilenirpm kktiaeivsy qvelrlpqtg
     3961 mkplpvfqrt nqllqdikll envtqeqnel lkvvikqtne wdeeienlkq ilnnysaqfs
     4021 lehmspdqad klpqlqgeie rmekqilsln qrkedllvdl katvlnlhqh lkqeqegver
     4081 drlpavtsee ggvaerdase rklnrrgsms ylaaveeeve essvksdngd ekaepspqsw
     4141 sslwkhdkdm eedrassssg tivqeaygki stsdnsmaqi ltpdslnteq gpecslrpnq
     4201 teegttppie adtldssdaq ggleprvekt rpeptevlha cktqvaelel wlqqanvave
     4261 petlnadmqq vleqqlvgcq amlteiehkv aflletckdq glgdngatqh eaealslklk
     4321 tvkcnlekvq mmlqekhsed qhptilkkss epehqealqp vnlselesiv terpqfsrqk
     4381 dfqqqqvlel kpmeqkdfik fiefnakkmw pqycqhdndt tqessasnqa sspendvpds
     4441 ilspqgqngd kwqylhhels skiklplpql vepqvstnmg ilpsvtmynf ryptteelkt
     4501 yttqledlrq easnlqtqen mteeayinld kklfelfltl sqclssveem lemprlyred
     4561 gsgqqvhyet lalelkklyl alsdkkgdll kamtwpgent nlllecfdnl qvclehtqaa
     4621 avcrskslka gldynrsyqn eikrlyhqli ksktslqqsl neisgqsvae qlqkadaytv
     4681 elenaesrva klrdegerlh lpyallqevy kledvldsmw gmlrarytel sspfvtesqq
     4741 dallqgmvel vkigkeklah ghlkqtkskv alqaqienhk vffqklvadm lliqaysaki
     4801 lpsllqnret fwaeqvtevk ileeksrqcg mklqsllqkw eefdenyasl ekdleilist
     4861 lpsvslveet eerlverisf yqqikrnigg kharlyqtln egkqlvasvs cpelegqiak
     4921 leeqwlslnk kidhelhrlq allkhllsyn rdsdqltkwl essqhtlnyw keqslnvsqd
     4981 ldtirsninn ffefskevde ksslktavis ignqllhlke tdtatlrasl aqfeqkwtml
     5041 itqlpdiqek lhqlqmeklp srkaitemis wmnnvehqts dedsvhspss asqvkhllqk
     5101 hkefrmemdy kqwivdfvnq sllqlstcdv eskryertef aehlgemnrq whrvhgmlnr
     5161 kiqhleqlle sitesenkiq ilnnwleaqe erlktlqkpe svisvqklll dcqdienqla
     5221 ikskaldelk qsyltlesga vplledtasr idelfqkrss vltqvnqlkt smqsvlqewk
     5281 iydqlydevn mmtirfwycm ehskpvvlsl etlrcqvenl qslqdeaess egsweklqev
     5341 igklkglcps vaeiieekcq nthkrwtqvn qaiadqlqka qsllqlwkay snahgeaaar
     5401 lkqqeakfqq lanismsgnn laeilppalq dikelqhdvq ktkeaflqns svldrlpqpa
     5461 essthmllpg plhslqraay lekmllvkan efefvlsqfk dfgvrleslk glimheeenl
     5521 drlhqqeken pdsflnhvla ltaqspdieh lnevslklpl sdvavktlqn mnrqwirata
     5581 talercselq giglnekfly ccekwiqlle kieealkvdv anslpelleq qktykmleae
     5641 vsinqtiads yvtqslqlld tteienrpef itefskltdr wqnavqgvrq rkgdvdglvr
     5701 qwqdfttsve nlfrfltdts hllsavkgqe rfslyqtrsl ihelknkeih fqrrrttcal
     5761 tleageklll ttdlktkesv grrisqlqds wkdmepqlae mikqfqstve twdqcekkik
     5821 elksrlqvlk aqsedplpel hedlhnekel ikeleqslas wtqnlkelqt mkadltrhvl
     5881 vedvmvlkeq iehlhrqwed lclrvairkq eiedrlntwv vfneknkelc awlvqmenkv
     5941 lqtadisiee mieklqkdcm eeinlfsenk lqlkqmgdql ikasnksraa eiddklnkin
     6001 drwqhlfdvi gsrvkklket fafiqqldkn msnlrtwlar ieselskpvv ydvcddqeiq
     6061 krlaeqqdlq rdieqhsagv esvfnicdvl lhdsdacane tecdsiqqtt rsldrrwrni
     6121 camsmerrmk ieetwrlwqk flddysrfed wlksaertaa cpnssevlyt sakeelkrfe
     6181 afqrqiherl tqlelinkqy rrlarenrtd tasrlkqmvh egnqrwdnlq rrvtavlrrl
     6241 rhftnqreef egtresilvw ltemdlqltn vehfsesdad dkmrqlngfq qeitlntnki
     6301 dqlivfgeql iqksepldav liedeleelh rycqevfgrv srfhrrltsc tpgledekea
     6361 senetdmedp reiqtdswrk rgeseepssp qslchlvapg hersgcetpv svdsiplewd
     6421 htgdvggsss heedeegpyy salsdveipe npeaylkmtt ktlkassgks isdghswhvp
     6481 dspscpehhy kqmegdrnvp pvppasstpy kppygklllp pgtdggkegp rvlngnpqqe
     6541 dgglagiteq qsgtacnwqs sreaeygafd rwemiqaqel hnklkikqnl qqlnsdisai
     6601 ttwlkkteae lemlkmakpp sdiqeielrv krlqeilkaf dtykalvvsv nvsskeflqt
     6661 espestelqs rlrqlsllwe aaqgavdswr gglrqslmqc qgsktrprsd vlffkdfhql
     6721 sqnlllwlas aknrrqkahv tdpkadpral lecrrelmql ekelverqpq vdmlqeisns
     6781 llikghgedc ieaeekvhvi ekklkqlreq vsqdlmalqg tqnpasplps fdevdsgdqp
     6841 patsvpapra kqfravrtte geeetesrvp gstrpqrsfl srvvraalpl qlllllllll
     6901 acllpsseed ysctqannfa rsfypmlryt ngpppt
//
LOCUS       XP_011534880            6935 aa            linear   PRI 05-AUG-2025
DEFINITION  nesprin-2 isoform X2 [Homo sapiens].
ACCESSION   XP_011534880
VERSION     XP_011534880.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536578.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..6935
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..6935
                     /product="nesprin-2 isoform X2"
                     /calculated_mol_wt=801939
     Region          28..138
                     /region_name="CH_SYNE2_rpt1"
                     /note="first calponin homology (CH) domain found in
                     synaptic nuclear envelope protein 2; cd21242"
                     /db_xref="CDD:409091"
     Site            order(33,37,89,91..92,95..96,98,107..115,120,122..123,
                     125..126,129..130,133)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409091"
     Region          178..286
                     /region_name="CH_SYNE2_rpt2"
                     /note="second calponin homology (CH) domain found in
                     synaptic nuclear envelope protein 2 (SYNE-2) and similar
                     proteins; cd21244"
                     /db_xref="CDD:409093"
     Site            order(183,187,237,239..240,243..244,246,255..263,270,
                     272..273,275..276,279..280,283)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409093"
     Region          <1418..2014
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          <1868..>2369
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          <2338..2712
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          2805..>3389
                     /region_name="CCDC158"
                     /note="Coiled-coil domain-containing protein 158;
                     pfam15921"
                     /db_xref="CDD:464943"
     Region          <3656..>3950
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <3811..4113
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <4496..5321
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          4945..5169
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            5054..5059
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5063..5276
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Region          5123..>5875
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Site            5168..5173
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5178..5384
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cl02488"
                     /db_xref="CDD:413338"
     Site            5275..5280
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5919..6133
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6020..6025
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          6137..6350
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6243..6248
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          6590..6813
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6696..6701
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          <6904..6935
                     /region_name="KASH"
                     /note="Nuclear envelope localization domain; pfam10541"
                     /db_xref="CDD:463142"
     CDS             1..6935
                     /gene="SYNE2"
                     /gene_synonym="EDMD5; KASH2; Nesp2; Nesprin-2; NUA;
                     NUANCE; SYNE-2; TROPH"
                     /coded_by="XM_011536578.2:192..20999"
                     /db_xref="GeneID:23224"
                     /db_xref="HGNC:HGNC:17084"
                     /db_xref="MIM:608442"
ORIGIN      
        1 masspelpte deqgswgidd lhislqaeqe dtqkkaftcw insqlarhts psvisdlftd
       61 ikkghvlldl levlsgqqlp rdkgsntfqc riniehaltf lrnrsiklin ihvtdiidgn
      121 psiilgliwt iilhfhiekl aqtlscnynq pslddvsvvd sspassppak kcskvqarwq
      181 msarkalllw aqeqcatyes vnvtdfkssw rngmaflaii halrpdlidm ksvkhrsnkd
      241 nlreafriae qelkiprlle pedvdvvdpd eksimtyvaq flqyskdapg tgeeaqgkvk
      301 damgwltlqk eklqkllkds endtyfkkyn sllsfmesfn eekksfldvl sikrdldeld
      361 kdhlqlreaw dgldhqinaw kiklnyalpp plhqteawlq eveelmdedl sasqdhsqav
      421 tliqekmtlf kslmdrfehh snilltfenk denhlplvpp nkleemkrri nnilekkfil
      481 llefhyykcl vlglvdevks kldiwnikyg sresvellle dwhkfieeke flarldtsfq
      541 kcgeiyknla gecqninkqy mmvksdvcmy rkniynvkst lqkvlacwat yvenlrllra
      601 cfeetkkeei kevpfetlaq wnlehatlne agnflvevsn dvvgssiske lrrlnkrwrk
      661 lvsktqlemn lplmikkqdq ptfdnsgnil skeekatvef stdmsvelpe nynqnikage
      721 khekeneeft gqlkvakdve kligqveiwe aeaksvldqd dvdtsmeesl khliakgsmf
      781 delmarsedm lqmdiqniss qesfqhvltt glqakiqeak ekvqinvvkl iaalknltdv
      841 spdldirlkm eesqkelesy mmraqqllgq respgelisk hkealiisnt kslakylkav
      901 eelknnvted ikmsleeksr dvcakweslh helslyvqql kidiekgkls dnilklekqi
      961 nkekklirrg rtkglikehe acfseegcly qlnhhmevlr elceelpsqk sqqevkrllk
     1021 dyeqkierll kcaseihmtl qptaggtskn egtittsenr ggdphseapf aksdnqpste
     1081 kameptmkfs lasvlrplqe esimekdysa sinslleryd tyrdilehhl qnnkfritsd
     1141 fsseedrsss clqakltdlq viknetdarw kefeiislkl enhvndikkp fvikerdtlk
     1201 ererelqmtl ntrmesleta lrlvlpveka slllcgsdlp lhkmaiqgfh lidadriyqh
     1261 lrniqdsiak qieicnrlee pgnfvlkelh pfdlhamqni ilkyktqfeg mnhrvqrsed
     1321 tlkaledfla slrtaklsae pvtdlsasdt qvaqentltv knkegeihlm kdkakhldkc
     1381 lkmldmsfkd aergddtsce nlldafsikl sethgygvqe efteenklle acifknnell
     1441 kniqdvqsqi skiglkdptv pavkhrkksl irldkvldey eeekrhlqem anslphfkdg
     1501 rektvnqqcq ntvvlwentk alvtecleqc grvlellkqy qnfksilttl iqkeesvisl
     1561 qasymgkenl kkriaeieiv keefnehlev vdkinqvckn lqfylnkmkt feeppfekea
     1621 niivdrwldi nektedyyen lgralalwdk lfnlknvide wtekalqkme lhqlteedre
     1681 rlkeelqvhe qktsefsrrv aeiqfllqss eiplelqvme ssilnkmehv qkcltgesnc
     1741 halsgstael redldqaktq igmtesllka lspsdsleif tkleeiqqqi lqqkhsmill
     1801 enqigcltpe lselkkqyes vsdlfntkks vlqdhfskll ndqcknfndw fsnikvnlke
     1861 cfessetkks veqklqklsd fltlegrnsk ikqvdsvlkh vkkhlpkahv keliswlvgq
     1921 efelekmesi cqarakeled slqqllrlqd dhrnlrkwlt nqeekwkgme epgektelfc
     1981 qalarkreqf esvaqlnnsl keygfteeee iimeatclmd ryqtllrqls eieeedkllp
     2041 tedqsfndla hdvihwikei keslmvlnss egkmpleeri qkikeiillk pegdarieti
     2101 mkqaesseap lvqktltdis nqwdntlhla stylshqekl llegekylqs kedlrlmlie
     2161 lkkkqeagfa lqhglqekka qlkiykkflk kaqdltsllk elksqgnyll ectknpsfse
     2221 epwleikhlh esllqqlqds vqnldghvre hdsyqvcvtd lnttldnfsk efvsfsdkpv
     2281 dqiaveeklq klqelenrls lqdgtlkkil alaksvkqnt ssvgqkiikd dikslqckqk
     2341 dlenrlasak qemecclnsi lkskrstekk gkftlpgrek qatsdvqest qesaavekle
     2401 edweinkdsa vemamskqls lnaqesmknt ederkvnelq nqpleldtml rneqleeiek
     2461 lytqleakka aikpleqtec lnktetgalv lhnigysaqh ldnllqalit lkknkesqyc
     2521 vlrdfqeyla avessmkall tdkeslkvgp ldsvtyldki kkfiasieke kdslgnlkik
     2581 wenlsnhvtd mdkkllesqi kqlehgweqv eqqiqkkysq qvveydeftt lmnkvqdtei
     2641 slqqqqqhlq lrlkspeera gnqsmialtt dlqatkhgfs vlkgqaelqm kriwgekekk
     2701 nledginnlk kqwetleplh leaenqikkc dirnkmketi lwaknllgel npsipllpdd
     2761 ilsqirkckv thdgilarqq sveslaeevk dkvpslttye gsdlnntled lrnqyqmlvl
     2821 kstqrsqqle fkleersnff aiirkfqlmv qesetliipr vetaateael khhhvtleas
     2881 qkelqeidsg isthlqeltn iyeelnvfer lfledqlknl kirtnriqrf iqntcneveh
     2941 kikfcrqfhe ktsalqeead siqrnellln qevnkgvkee iynlkdrlta ikccilqvlk
     3001 lkkvfdyigl nwdfsqldql qtqvfekeke leekikqldt feeehgkyqa llskmraidl
     3061 qikkmtevvl kapdsspesr rlnaqilsqr iekakclcde iikklnenkt fddsfkekei
     3121 lqiklnaeen dklykvlqnm vlelspkeld ekncqdklet slhvlnqiks qlqqpllinl
     3181 eikhiqnekd nceafqeqvw aemcsikavt aiekqreens seasdvetkl refedlqmql
     3241 ntsidlrtnv lndayenltr ykeavtrave sitsleaiii pyrvdvgnpe eslemplrkq
     3301 eelestvahi qdlteklgmi sspeaklqlq ytlqelvskn samkeafkaq eteaerylen
     3361 ykcyrkmeed iytnlskmet vlgqsmsslp lsyrealerl eqskalvsnl istkeelmkl
     3421 rqilrllrlr ctendgicll kivsalwekw lslleaakew emwceelkqe wkfvseeier
     3481 eaiildnlqe elpeisktke aatteelsel ldclcqygen vekqqllltl llqrirsiqn
     3541 vpessgavet vpafqeitsm kercnkllqk vqknkelvqt eiqerhsftk eiialknffq
     3601 qtttsfqnma fqdhpekseq feelqsilkk gkltfenime klrikysemy tivpaeiesq
     3661 veecrkaled idekisnevl ksspsyamrr kieeinnglh nvekmlqqks kniekaqeiq
     3721 kkmwdeldlw hsklneldse vqdiveqdpg qaqewmdnlm ipfqqyqqvs qraecrtsql
     3781 nkatvkmeey sdllksteaw ientshllan padydslrtl shhastvqma ledseqkhnl
     3841 lhsifmdled lsiifetdel tqsiqelsnq vtalqqkime slpqiqrmad dvvaiesevk
     3901 smekrvskik tillskeifd fspeehlkhg evilenirpm kktiaeivsy qvelrlpqtg
     3961 mkplpvfqrt nqllqdikll envtqeqnel lkvvikqtne wdeeienlkq ilnnysaqfs
     4021 lehmspdqad klpqlqgeie rmekqilsln qrkedllvdl katvlnlhqh lkqeqegver
     4081 drlpavtsee ggvaerdase rklnrrgsms ylaaveeeve essvksdngd ekaepspqsw
     4141 sslwkhdkdm eedrassssg tivqeaygki stsdnsmaqi ltpdslnteq gpecslrpnq
     4201 teegttppie adtldssdaq ggleprvekt rpeptevlha cktqvaelel wlqqanvave
     4261 petlnadmqq vleqqlvgcq amlteiehkv aflletckdq glgdngatqh eaealslklk
     4321 tvkcnlekvq mmlqekhsed qhptilkkss epehqealqp vnlselesiv terpqfsrqk
     4381 dfqqqqvlel kpmeqkdfik fiefnakkmw pqycqhdndt tqessasnqa sspendvpds
     4441 ilspqgqngd kwqylhhels skiklplpql vepqvstnmg ilpsvtmynf ryptteelkt
     4501 yttqledlrq easnlqtqen mteeayinld kklfelfltl sqclssveem lemprlyred
     4561 gsgqqvhyet lalelkklyl alsdkkgdll kamtwpgent nlllecfdnl qvclehtqaa
     4621 avcrskslka gldynrsyqn eikrlyhqli ksktslqqsl neisgqsvae qlqkadaytv
     4681 elenaesrva klrdegerlh lpyallqevy kledvldsmw gmlrarytel sspfvtesqq
     4741 dallqgmvel vkigkeklah ghlkqtkskv alqaqienhk vffqklvadm lliqaysaki
     4801 lpsllqnret fwaeqvtevk ileeksrqcg mklqsllqkw eefdenyasl ekdleilist
     4861 lpsvslveet eerlverisf yqqikrnigg kharlyqtln egkqlvasvs cpelegqiak
     4921 leeqwlslnk kidhelhrlq allkhllsyn rdsdqltkwl essqhtlnyw keqslnvsqd
     4981 ldtirsninn ffefskevde ksslktavis ignqllhlke tdtatlrasl aqfeqkwtml
     5041 itqlpdiqek lhqlqmeklp srkaitemis wmnnvehqts dedsvhspss asqvkhllqk
     5101 hkefrmemdy kqwivdfvnq sllqlstcdv eskryertef aehlgemnrq whrvhgmlnr
     5161 kiqhleqlle sitesenkiq ilnnwleaqe erlktlqkpe svisvqklll dcqdienqla
     5221 ikskaldelk qsyltlesga vplledtasr idelfqkrss vltqvnqlkt smqsvlqewk
     5281 iydqlydevn mmtirfwycm ehskpvvlsl etlrcqvenl qslqdeaess egsweklqev
     5341 igklkglcps vaeiieekcq nthkrwtqvn qaiadqlqka qsllqlwkay snahgeaaar
     5401 lkqqeakfqq lanismsgnn laeilppalq dikelqhdvq ktkeaflqns svldrlpqpa
     5461 essthmllpg plhslqraay lekmllvkan efefvlsqfk dfgvrleslk glimheeenl
     5521 drlhqqeken pdsflnhvla ltaqspdieh lnevslklpl sdvavktlqn mnrqwirata
     5581 talercselq giglnekfly ccekwiqlle kieealkvdv anslpelleq qktykmleae
     5641 vsinqtiads yvtqslqlld tteienrpef itefskltdr wqnavqgvrq rkgdvdglvr
     5701 qwqdfttsve nlfrfltdts hllsavkgqe rfslyqtrsl ihelknkeih fqrrrttcal
     5761 tleageklll ttdlktkesv grrisqlqds wkdmepqlae mikqfqstve twdqcekkik
     5821 elksrlqvlk aqsedplpel hedlhnekel ikeleqslas wtqnlkelqt mkadltrhvl
     5881 vedvmvlkeq iehlhrqwed lclrvairkq eiedrlntwv vfneknkelc awlvqmenkv
     5941 lqtadisiee mieklqkdcm eeinlfsenk lqlkqmgdql ikasnksraa eiddklnkin
     6001 drwqhlfdvi gsrvkklket fafiqqldkn msnlrtwlar ieselskpvv ydvcddqeiq
     6061 krlaeqqdlq rdieqhsagv esvfnicdvl lhdsdacane tecdsiqqtt rsldrrwrni
     6121 camsmerrmk ieetwrlwqk flddysrfed wlksaertaa cpnssevlyt sakeelkrfe
     6181 afqrqiherl tqlelinkqy rrlarenrtd tasrlkqmvh egnqrwdnlq rrvtavlrrl
     6241 rhftnqreef egtresilvw ltemdlqltn vehfsesdad dkmrqlngfq qeitlntnki
     6301 dqlivfgeql iqksepldav liedeleelh rycqevfgrv srfhrrltsc tpgledekea
     6361 senetdmedp reiqtdswrk rgeseepssp qslchlvapg hersgcetpv svdsiplewd
     6421 htgdvggsss heedeegpyy salsdveipe npeaylkmtt ktlkassgks isdghswhvp
     6481 dspscpehhy kqmegdrnvp pvppasstpy kppygklllp pgtdggkegp rvlngnpqqe
     6541 dgglagiteq qsgtacnwqs sreaeygafd rwemiqaqel hnklkikqnl qqlnsdisai
     6601 ttwlkkteae lemlkmakpp sdiqeielrv krlqeilkaf dtykalvvsv nvsskeflqt
     6661 espestelqs rlrqlsllwe aaqgavdswr gglrqslmqc qgsktrprsd vlffkdfhql
     6721 sqnlllwlas aknrrqkahv tdpkadpral lecrrelmql ekelverqpq vdmlqeisns
     6781 llikghgedc ieaeekvhvi ekklkqlreq vsqdlmalqg tqnpasplps fdevdsgdqp
     6841 patsvpapra kfravrtteg eeetesrvpg strpqrsfls rvvraalplq llllllllla
     6901 cllpsseedy sctqannfar sfypmlrytn gpppt
//
LOCUS       XP_011534881            6922 aa            linear   PRI 05-AUG-2025
DEFINITION  nesprin-2 isoform X3 [Homo sapiens].
ACCESSION   XP_011534881
VERSION     XP_011534881.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536579.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..6922
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..6922
                     /product="nesprin-2 isoform X3"
                     /calculated_mol_wt=800447
     Region          28..138
                     /region_name="CH_SYNE2_rpt1"
                     /note="first calponin homology (CH) domain found in
                     synaptic nuclear envelope protein 2; cd21242"
                     /db_xref="CDD:409091"
     Site            order(33,37,89,91..92,95..96,98,107..115,120,122..123,
                     125..126,129..130,133)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409091"
     Region          178..286
                     /region_name="CH_SYNE2_rpt2"
                     /note="second calponin homology (CH) domain found in
                     synaptic nuclear envelope protein 2 (SYNE-2) and similar
                     proteins; cd21244"
                     /db_xref="CDD:409093"
     Site            order(183,187,237,239..240,243..244,246,255..263,270,
                     272..273,275..276,279..280,283)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409093"
     Region          <1418..2014
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          <1868..>2369
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          <2338..2712
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          2805..>3389
                     /region_name="CCDC158"
                     /note="Coiled-coil domain-containing protein 158;
                     pfam15921"
                     /db_xref="CDD:464943"
     Region          <3656..>3950
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <3811..4113
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <4496..5321
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          4945..5169
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            5054..5059
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5063..5276
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Region          5123..>5875
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Site            5168..5173
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5178..5384
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cl02488"
                     /db_xref="CDD:413338"
     Site            5275..5280
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5919..6133
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6020..6025
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          6137..6350
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6243..6248
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          6590..6799
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6696..6701
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          <6891..6922
                     /region_name="KASH"
                     /note="Nuclear envelope localization domain; pfam10541"
                     /db_xref="CDD:463142"
     CDS             1..6922
                     /gene="SYNE2"
                     /gene_synonym="EDMD5; KASH2; Nesp2; Nesprin-2; NUA;
                     NUANCE; SYNE-2; TROPH"
                     /coded_by="XM_011536579.2:192..20960"
                     /db_xref="GeneID:23224"
                     /db_xref="HGNC:HGNC:17084"
                     /db_xref="MIM:608442"
ORIGIN      
        1 masspelpte deqgswgidd lhislqaeqe dtqkkaftcw insqlarhts psvisdlftd
       61 ikkghvlldl levlsgqqlp rdkgsntfqc riniehaltf lrnrsiklin ihvtdiidgn
      121 psiilgliwt iilhfhiekl aqtlscnynq pslddvsvvd sspassppak kcskvqarwq
      181 msarkalllw aqeqcatyes vnvtdfkssw rngmaflaii halrpdlidm ksvkhrsnkd
      241 nlreafriae qelkiprlle pedvdvvdpd eksimtyvaq flqyskdapg tgeeaqgkvk
      301 damgwltlqk eklqkllkds endtyfkkyn sllsfmesfn eekksfldvl sikrdldeld
      361 kdhlqlreaw dgldhqinaw kiklnyalpp plhqteawlq eveelmdedl sasqdhsqav
      421 tliqekmtlf kslmdrfehh snilltfenk denhlplvpp nkleemkrri nnilekkfil
      481 llefhyykcl vlglvdevks kldiwnikyg sresvellle dwhkfieeke flarldtsfq
      541 kcgeiyknla gecqninkqy mmvksdvcmy rkniynvkst lqkvlacwat yvenlrllra
      601 cfeetkkeei kevpfetlaq wnlehatlne agnflvevsn dvvgssiske lrrlnkrwrk
      661 lvsktqlemn lplmikkqdq ptfdnsgnil skeekatvef stdmsvelpe nynqnikage
      721 khekeneeft gqlkvakdve kligqveiwe aeaksvldqd dvdtsmeesl khliakgsmf
      781 delmarsedm lqmdiqniss qesfqhvltt glqakiqeak ekvqinvvkl iaalknltdv
      841 spdldirlkm eesqkelesy mmraqqllgq respgelisk hkealiisnt kslakylkav
      901 eelknnvted ikmsleeksr dvcakweslh helslyvqql kidiekgkls dnilklekqi
      961 nkekklirrg rtkglikehe acfseegcly qlnhhmevlr elceelpsqk sqqevkrllk
     1021 dyeqkierll kcaseihmtl qptaggtskn egtittsenr ggdphseapf aksdnqpste
     1081 kameptmkfs lasvlrplqe esimekdysa sinslleryd tyrdilehhl qnnkfritsd
     1141 fsseedrsss clqakltdlq viknetdarw kefeiislkl enhvndikkp fvikerdtlk
     1201 ererelqmtl ntrmesleta lrlvlpveka slllcgsdlp lhkmaiqgfh lidadriyqh
     1261 lrniqdsiak qieicnrlee pgnfvlkelh pfdlhamqni ilkyktqfeg mnhrvqrsed
     1321 tlkaledfla slrtaklsae pvtdlsasdt qvaqentltv knkegeihlm kdkakhldkc
     1381 lkmldmsfkd aergddtsce nlldafsikl sethgygvqe efteenklle acifknnell
     1441 kniqdvqsqi skiglkdptv pavkhrkksl irldkvldey eeekrhlqem anslphfkdg
     1501 rektvnqqcq ntvvlwentk alvtecleqc grvlellkqy qnfksilttl iqkeesvisl
     1561 qasymgkenl kkriaeieiv keefnehlev vdkinqvckn lqfylnkmkt feeppfekea
     1621 niivdrwldi nektedyyen lgralalwdk lfnlknvide wtekalqkme lhqlteedre
     1681 rlkeelqvhe qktsefsrrv aeiqfllqss eiplelqvme ssilnkmehv qkcltgesnc
     1741 halsgstael redldqaktq igmtesllka lspsdsleif tkleeiqqqi lqqkhsmill
     1801 enqigcltpe lselkkqyes vsdlfntkks vlqdhfskll ndqcknfndw fsnikvnlke
     1861 cfessetkks veqklqklsd fltlegrnsk ikqvdsvlkh vkkhlpkahv keliswlvgq
     1921 efelekmesi cqarakeled slqqllrlqd dhrnlrkwlt nqeekwkgme epgektelfc
     1981 qalarkreqf esvaqlnnsl keygfteeee iimeatclmd ryqtllrqls eieeedkllp
     2041 tedqsfndla hdvihwikei keslmvlnss egkmpleeri qkikeiillk pegdarieti
     2101 mkqaesseap lvqktltdis nqwdntlhla stylshqekl llegekylqs kedlrlmlie
     2161 lkkkqeagfa lqhglqekka qlkiykkflk kaqdltsllk elksqgnyll ectknpsfse
     2221 epwleikhlh esllqqlqds vqnldghvre hdsyqvcvtd lnttldnfsk efvsfsdkpv
     2281 dqiaveeklq klqelenrls lqdgtlkkil alaksvkqnt ssvgqkiikd dikslqckqk
     2341 dlenrlasak qemecclnsi lkskrstekk gkftlpgrek qatsdvqest qesaavekle
     2401 edweinkdsa vemamskqls lnaqesmknt ederkvnelq nqpleldtml rneqleeiek
     2461 lytqleakka aikpleqtec lnktetgalv lhnigysaqh ldnllqalit lkknkesqyc
     2521 vlrdfqeyla avessmkall tdkeslkvgp ldsvtyldki kkfiasieke kdslgnlkik
     2581 wenlsnhvtd mdkkllesqi kqlehgweqv eqqiqkkysq qvveydeftt lmnkvqdtei
     2641 slqqqqqhlq lrlkspeera gnqsmialtt dlqatkhgfs vlkgqaelqm kriwgekekk
     2701 nledginnlk kqwetleplh leaenqikkc dirnkmketi lwaknllgel npsipllpdd
     2761 ilsqirkckv thdgilarqq sveslaeevk dkvpslttye gsdlnntled lrnqyqmlvl
     2821 kstqrsqqle fkleersnff aiirkfqlmv qesetliipr vetaateael khhhvtleas
     2881 qkelqeidsg isthlqeltn iyeelnvfer lfledqlknl kirtnriqrf iqntcneveh
     2941 kikfcrqfhe ktsalqeead siqrnellln qevnkgvkee iynlkdrlta ikccilqvlk
     3001 lkkvfdyigl nwdfsqldql qtqvfekeke leekikqldt feeehgkyqa llskmraidl
     3061 qikkmtevvl kapdsspesr rlnaqilsqr iekakclcde iikklnenkt fddsfkekei
     3121 lqiklnaeen dklykvlqnm vlelspkeld ekncqdklet slhvlnqiks qlqqpllinl
     3181 eikhiqnekd nceafqeqvw aemcsikavt aiekqreens seasdvetkl refedlqmql
     3241 ntsidlrtnv lndayenltr ykeavtrave sitsleaiii pyrvdvgnpe eslemplrkq
     3301 eelestvahi qdlteklgmi sspeaklqlq ytlqelvskn samkeafkaq eteaerylen
     3361 ykcyrkmeed iytnlskmet vlgqsmsslp lsyrealerl eqskalvsnl istkeelmkl
     3421 rqilrllrlr ctendgicll kivsalwekw lslleaakew emwceelkqe wkfvseeier
     3481 eaiildnlqe elpeisktke aatteelsel ldclcqygen vekqqllltl llqrirsiqn
     3541 vpessgavet vpafqeitsm kercnkllqk vqknkelvqt eiqerhsftk eiialknffq
     3601 qtttsfqnma fqdhpekseq feelqsilkk gkltfenime klrikysemy tivpaeiesq
     3661 veecrkaled idekisnevl ksspsyamrr kieeinnglh nvekmlqqks kniekaqeiq
     3721 kkmwdeldlw hsklneldse vqdiveqdpg qaqewmdnlm ipfqqyqqvs qraecrtsql
     3781 nkatvkmeey sdllksteaw ientshllan padydslrtl shhastvqma ledseqkhnl
     3841 lhsifmdled lsiifetdel tqsiqelsnq vtalqqkime slpqiqrmad dvvaiesevk
     3901 smekrvskik tillskeifd fspeehlkhg evilenirpm kktiaeivsy qvelrlpqtg
     3961 mkplpvfqrt nqllqdikll envtqeqnel lkvvikqtne wdeeienlkq ilnnysaqfs
     4021 lehmspdqad klpqlqgeie rmekqilsln qrkedllvdl katvlnlhqh lkqeqegver
     4081 drlpavtsee ggvaerdase rklnrrgsms ylaaveeeve essvksdngd ekaepspqsw
     4141 sslwkhdkdm eedrassssg tivqeaygki stsdnsmaqi ltpdslnteq gpecslrpnq
     4201 teegttppie adtldssdaq ggleprvekt rpeptevlha cktqvaelel wlqqanvave
     4261 petlnadmqq vleqqlvgcq amlteiehkv aflletckdq glgdngatqh eaealslklk
     4321 tvkcnlekvq mmlqekhsed qhptilkkss epehqealqp vnlselesiv terpqfsrqk
     4381 dfqqqqvlel kpmeqkdfik fiefnakkmw pqycqhdndt tqessasnqa sspendvpds
     4441 ilspqgqngd kwqylhhels skiklplpql vepqvstnmg ilpsvtmynf ryptteelkt
     4501 yttqledlrq easnlqtqen mteeayinld kklfelfltl sqclssveem lemprlyred
     4561 gsgqqvhyet lalelkklyl alsdkkgdll kamtwpgent nlllecfdnl qvclehtqaa
     4621 avcrskslka gldynrsyqn eikrlyhqli ksktslqqsl neisgqsvae qlqkadaytv
     4681 elenaesrva klrdegerlh lpyallqevy kledvldsmw gmlrarytel sspfvtesqq
     4741 dallqgmvel vkigkeklah ghlkqtkskv alqaqienhk vffqklvadm lliqaysaki
     4801 lpsllqnret fwaeqvtevk ileeksrqcg mklqsllqkw eefdenyasl ekdleilist
     4861 lpsvslveet eerlverisf yqqikrnigg kharlyqtln egkqlvasvs cpelegqiak
     4921 leeqwlslnk kidhelhrlq allkhllsyn rdsdqltkwl essqhtlnyw keqslnvsqd
     4981 ldtirsninn ffefskevde ksslktavis ignqllhlke tdtatlrasl aqfeqkwtml
     5041 itqlpdiqek lhqlqmeklp srkaitemis wmnnvehqts dedsvhspss asqvkhllqk
     5101 hkefrmemdy kqwivdfvnq sllqlstcdv eskryertef aehlgemnrq whrvhgmlnr
     5161 kiqhleqlle sitesenkiq ilnnwleaqe erlktlqkpe svisvqklll dcqdienqla
     5221 ikskaldelk qsyltlesga vplledtasr idelfqkrss vltqvnqlkt smqsvlqewk
     5281 iydqlydevn mmtirfwycm ehskpvvlsl etlrcqvenl qslqdeaess egsweklqev
     5341 igklkglcps vaeiieekcq nthkrwtqvn qaiadqlqka qsllqlwkay snahgeaaar
     5401 lkqqeakfqq lanismsgnn laeilppalq dikelqhdvq ktkeaflqns svldrlpqpa
     5461 essthmllpg plhslqraay lekmllvkan efefvlsqfk dfgvrleslk glimheeenl
     5521 drlhqqeken pdsflnhvla ltaqspdieh lnevslklpl sdvavktlqn mnrqwirata
     5581 talercselq giglnekfly ccekwiqlle kieealkvdv anslpelleq qktykmleae
     5641 vsinqtiads yvtqslqlld tteienrpef itefskltdr wqnavqgvrq rkgdvdglvr
     5701 qwqdfttsve nlfrfltdts hllsavkgqe rfslyqtrsl ihelknkeih fqrrrttcal
     5761 tleageklll ttdlktkesv grrisqlqds wkdmepqlae mikqfqstve twdqcekkik
     5821 elksrlqvlk aqsedplpel hedlhnekel ikeleqslas wtqnlkelqt mkadltrhvl
     5881 vedvmvlkeq iehlhrqwed lclrvairkq eiedrlntwv vfneknkelc awlvqmenkv
     5941 lqtadisiee mieklqkdcm eeinlfsenk lqlkqmgdql ikasnksraa eiddklnkin
     6001 drwqhlfdvi gsrvkklket fafiqqldkn msnlrtwlar ieselskpvv ydvcddqeiq
     6061 krlaeqqdlq rdieqhsagv esvfnicdvl lhdsdacane tecdsiqqtt rsldrrwrni
     6121 camsmerrmk ieetwrlwqk flddysrfed wlksaertaa cpnssevlyt sakeelkrfe
     6181 afqrqiherl tqlelinkqy rrlarenrtd tasrlkqmvh egnqrwdnlq rrvtavlrrl
     6241 rhftnqreef egtresilvw ltemdlqltn vehfsesdad dkmrqlngfq qeitlntnki
     6301 dqlivfgeql iqksepldav liedeleelh rycqevfgrv srfhrrltsc tpgledekea
     6361 senetdmedp reiqtdswrk rgeseepssp qslchlvapg hersgcetpv svdsiplewd
     6421 htgdvggsss heedeegpyy salsdveipe npeaylkmtt ktlkassgks isdghswhvp
     6481 dspscpehhy kqmegdrnvp pvppasstpy kppygklllp pgtdggkegp rvlngnpqqe
     6541 dgglagiteq qsgtacnwqs sreaeygafd rwemiqaqel hnklkikqnl qqlnsdisai
     6601 ttwlkkteae lemlkmakpp sdiqeielrv krlqeilkaf dtykalvvsv nvsskeflqt
     6661 espestelqs rlrqlsllwe aaqgavdswr gglrqslmqc qdfhqlsqnl llwlasaknr
     6721 rqkahvtdpk adprallecr relmqlekel verqpqvdml qeisnsllik ghgedcieae
     6781 ekvhviekkl kqlreqvsqd lmalqgtqnp asplpsfdev dsgdqppats vpaprakqfr
     6841 avrttegeee tesrvpgstr pqrsflsrvv raalplqlll llllllacll psseedysct
     6901 qannfarsfy pmlrytngpp pt
//
LOCUS       XP_005267511            6922 aa            linear   PRI 05-AUG-2025
DEFINITION  nesprin-2 isoform X4 [Homo sapiens].
ACCESSION   XP_005267511
VERSION     XP_005267511.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267454.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..6922
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..6922
                     /product="nesprin-2 isoform X4"
                     /calculated_mol_wt=800483
     Region          28..138
                     /region_name="CH_SYNE2_rpt1"
                     /note="first calponin homology (CH) domain found in
                     synaptic nuclear envelope protein 2; cd21242"
                     /db_xref="CDD:409091"
     Site            order(33,37,89,91..92,95..96,98,107..115,120,122..123,
                     125..126,129..130,133)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409091"
     Region          178..286
                     /region_name="CH_SYNE2_rpt2"
                     /note="second calponin homology (CH) domain found in
                     synaptic nuclear envelope protein 2 (SYNE-2) and similar
                     proteins; cd21244"
                     /db_xref="CDD:409093"
     Site            order(183,187,237,239..240,243..244,246,255..263,270,
                     272..273,275..276,279..280,283)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409093"
     Region          <1418..2014
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          <1868..2417
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          <2338..2712
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          2805..>3389
                     /region_name="CCDC158"
                     /note="Coiled-coil domain-containing protein 158;
                     pfam15921"
                     /db_xref="CDD:464943"
     Region          <3656..>3950
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <3811..4113
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <4496..5321
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          4945..5169
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            5054..5059
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5063..5276
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Region          5123..>5875
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Site            5168..5173
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5178..5384
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cl02488"
                     /db_xref="CDD:413338"
     Site            5275..5280
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5919..6133
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6020..6025
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          6137..6350
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6243..6248
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          6576..6799
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6682..6687
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          <6891..6922
                     /region_name="KASH"
                     /note="Nuclear envelope localization domain; pfam10541"
                     /db_xref="CDD:463142"
     CDS             1..6922
                     /gene="SYNE2"
                     /gene_synonym="EDMD5; KASH2; Nesp2; Nesprin-2; NUA;
                     NUANCE; SYNE-2; TROPH"
                     /coded_by="XM_005267454.2:192..20960"
                     /db_xref="GeneID:23224"
                     /db_xref="HGNC:HGNC:17084"
                     /db_xref="MIM:608442"
ORIGIN      
        1 masspelpte deqgswgidd lhislqaeqe dtqkkaftcw insqlarhts psvisdlftd
       61 ikkghvlldl levlsgqqlp rdkgsntfqc riniehaltf lrnrsiklin ihvtdiidgn
      121 psiilgliwt iilhfhiekl aqtlscnynq pslddvsvvd sspassppak kcskvqarwq
      181 msarkalllw aqeqcatyes vnvtdfkssw rngmaflaii halrpdlidm ksvkhrsnkd
      241 nlreafriae qelkiprlle pedvdvvdpd eksimtyvaq flqyskdapg tgeeaqgkvk
      301 damgwltlqk eklqkllkds endtyfkkyn sllsfmesfn eekksfldvl sikrdldeld
      361 kdhlqlreaw dgldhqinaw kiklnyalpp plhqteawlq eveelmdedl sasqdhsqav
      421 tliqekmtlf kslmdrfehh snilltfenk denhlplvpp nkleemkrri nnilekkfil
      481 llefhyykcl vlglvdevks kldiwnikyg sresvellle dwhkfieeke flarldtsfq
      541 kcgeiyknla gecqninkqy mmvksdvcmy rkniynvkst lqkvlacwat yvenlrllra
      601 cfeetkkeei kevpfetlaq wnlehatlne agnflvevsn dvvgssiske lrrlnkrwrk
      661 lvsktqlemn lplmikkqdq ptfdnsgnil skeekatvef stdmsvelpe nynqnikage
      721 khekeneeft gqlkvakdve kligqveiwe aeaksvldqd dvdtsmeesl khliakgsmf
      781 delmarsedm lqmdiqniss qesfqhvltt glqakiqeak ekvqinvvkl iaalknltdv
      841 spdldirlkm eesqkelesy mmraqqllgq respgelisk hkealiisnt kslakylkav
      901 eelknnvted ikmsleeksr dvcakweslh helslyvqql kidiekgkls dnilklekqi
      961 nkekklirrg rtkglikehe acfseegcly qlnhhmevlr elceelpsqk sqqevkrllk
     1021 dyeqkierll kcaseihmtl qptaggtskn egtittsenr ggdphseapf aksdnqpste
     1081 kameptmkfs lasvlrplqe esimekdysa sinslleryd tyrdilehhl qnnkfritsd
     1141 fsseedrsss clqakltdlq viknetdarw kefeiislkl enhvndikkp fvikerdtlk
     1201 ererelqmtl ntrmesleta lrlvlpveka slllcgsdlp lhkmaiqgfh lidadriyqh
     1261 lrniqdsiak qieicnrlee pgnfvlkelh pfdlhamqni ilkyktqfeg mnhrvqrsed
     1321 tlkaledfla slrtaklsae pvtdlsasdt qvaqentltv knkegeihlm kdkakhldkc
     1381 lkmldmsfkd aergddtsce nlldafsikl sethgygvqe efteenklle acifknnell
     1441 kniqdvqsqi skiglkdptv pavkhrkksl irldkvldey eeekrhlqem anslphfkdg
     1501 rektvnqqcq ntvvlwentk alvtecleqc grvlellkqy qnfksilttl iqkeesvisl
     1561 qasymgkenl kkriaeieiv keefnehlev vdkinqvckn lqfylnkmkt feeppfekea
     1621 niivdrwldi nektedyyen lgralalwdk lfnlknvide wtekalqkme lhqlteedre
     1681 rlkeelqvhe qktsefsrrv aeiqfllqss eiplelqvme ssilnkmehv qkcltgesnc
     1741 halsgstael redldqaktq igmtesllka lspsdsleif tkleeiqqqi lqqkhsmill
     1801 enqigcltpe lselkkqyes vsdlfntkks vlqdhfskll ndqcknfndw fsnikvnlke
     1861 cfessetkks veqklqklsd fltlegrnsk ikqvdsvlkh vkkhlpkahv keliswlvgq
     1921 efelekmesi cqarakeled slqqllrlqd dhrnlrkwlt nqeekwkgme epgektelfc
     1981 qalarkreqf esvaqlnnsl keygfteeee iimeatclmd ryqtllrqls eieeedkllp
     2041 tedqsfndla hdvihwikei keslmvlnss egkmpleeri qkikeiillk pegdarieti
     2101 mkqaesseap lvqktltdis nqwdntlhla stylshqekl llegekylqs kedlrlmlie
     2161 lkkkqeagfa lqhglqekka qlkiykkflk kaqdltsllk elksqgnyll ectknpsfse
     2221 epwleikhlh esllqqlqds vqnldghvre hdsyqvcvtd lnttldnfsk efvsfsdkpv
     2281 dqiaveeklq klqelenrls lqdgtlkkil alaksvkqnt ssvgqkiikd dikslqckqk
     2341 dlenrlasak qemecclnsi lkskrstekk gkftlpgrek qatsdvqest qesaavekle
     2401 edweinkdsa vemamskqls lnaqesmknt ederkvnelq nqpleldtml rneqleeiek
     2461 lytqleakka aikpleqtec lnktetgalv lhnigysaqh ldnllqalit lkknkesqyc
     2521 vlrdfqeyla avessmkall tdkeslkvgp ldsvtyldki kkfiasieke kdslgnlkik
     2581 wenlsnhvtd mdkkllesqi kqlehgweqv eqqiqkkysq qvveydeftt lmnkvqdtei
     2641 slqqqqqhlq lrlkspeera gnqsmialtt dlqatkhgfs vlkgqaelqm kriwgekekk
     2701 nledginnlk kqwetleplh leaenqikkc dirnkmketi lwaknllgel npsipllpdd
     2761 ilsqirkckv thdgilarqq sveslaeevk dkvpslttye gsdlnntled lrnqyqmlvl
     2821 kstqrsqqle fkleersnff aiirkfqlmv qesetliipr vetaateael khhhvtleas
     2881 qkelqeidsg isthlqeltn iyeelnvfer lfledqlknl kirtnriqrf iqntcneveh
     2941 kikfcrqfhe ktsalqeead siqrnellln qevnkgvkee iynlkdrlta ikccilqvlk
     3001 lkkvfdyigl nwdfsqldql qtqvfekeke leekikqldt feeehgkyqa llskmraidl
     3061 qikkmtevvl kapdsspesr rlnaqilsqr iekakclcde iikklnenkt fddsfkekei
     3121 lqiklnaeen dklykvlqnm vlelspkeld ekncqdklet slhvlnqiks qlqqpllinl
     3181 eikhiqnekd nceafqeqvw aemcsikavt aiekqreens seasdvetkl refedlqmql
     3241 ntsidlrtnv lndayenltr ykeavtrave sitsleaiii pyrvdvgnpe eslemplrkq
     3301 eelestvahi qdlteklgmi sspeaklqlq ytlqelvskn samkeafkaq eteaerylen
     3361 ykcyrkmeed iytnlskmet vlgqsmsslp lsyrealerl eqskalvsnl istkeelmkl
     3421 rqilrllrlr ctendgicll kivsalwekw lslleaakew emwceelkqe wkfvseeier
     3481 eaiildnlqe elpeisktke aatteelsel ldclcqygen vekqqllltl llqrirsiqn
     3541 vpessgavet vpafqeitsm kercnkllqk vqknkelvqt eiqerhsftk eiialknffq
     3601 qtttsfqnma fqdhpekseq feelqsilkk gkltfenime klrikysemy tivpaeiesq
     3661 veecrkaled idekisnevl ksspsyamrr kieeinnglh nvekmlqqks kniekaqeiq
     3721 kkmwdeldlw hsklneldse vqdiveqdpg qaqewmdnlm ipfqqyqqvs qraecrtsql
     3781 nkatvkmeey sdllksteaw ientshllan padydslrtl shhastvqma ledseqkhnl
     3841 lhsifmdled lsiifetdel tqsiqelsnq vtalqqkime slpqiqrmad dvvaiesevk
     3901 smekrvskik tillskeifd fspeehlkhg evilenirpm kktiaeivsy qvelrlpqtg
     3961 mkplpvfqrt nqllqdikll envtqeqnel lkvvikqtne wdeeienlkq ilnnysaqfs
     4021 lehmspdqad klpqlqgeie rmekqilsln qrkedllvdl katvlnlhqh lkqeqegver
     4081 drlpavtsee ggvaerdase rklnrrgsms ylaaveeeve essvksdngd ekaepspqsw
     4141 sslwkhdkdm eedrassssg tivqeaygki stsdnsmaqi ltpdslnteq gpecslrpnq
     4201 teegttppie adtldssdaq ggleprvekt rpeptevlha cktqvaelel wlqqanvave
     4261 petlnadmqq vleqqlvgcq amlteiehkv aflletckdq glgdngatqh eaealslklk
     4321 tvkcnlekvq mmlqekhsed qhptilkkss epehqealqp vnlselesiv terpqfsrqk
     4381 dfqqqqvlel kpmeqkdfik fiefnakkmw pqycqhdndt tqessasnqa sspendvpds
     4441 ilspqgqngd kwqylhhels skiklplpql vepqvstnmg ilpsvtmynf ryptteelkt
     4501 yttqledlrq easnlqtqen mteeayinld kklfelfltl sqclssveem lemprlyred
     4561 gsgqqvhyet lalelkklyl alsdkkgdll kamtwpgent nlllecfdnl qvclehtqaa
     4621 avcrskslka gldynrsyqn eikrlyhqli ksktslqqsl neisgqsvae qlqkadaytv
     4681 elenaesrva klrdegerlh lpyallqevy kledvldsmw gmlrarytel sspfvtesqq
     4741 dallqgmvel vkigkeklah ghlkqtkskv alqaqienhk vffqklvadm lliqaysaki
     4801 lpsllqnret fwaeqvtevk ileeksrqcg mklqsllqkw eefdenyasl ekdleilist
     4861 lpsvslveet eerlverisf yqqikrnigg kharlyqtln egkqlvasvs cpelegqiak
     4921 leeqwlslnk kidhelhrlq allkhllsyn rdsdqltkwl essqhtlnyw keqslnvsqd
     4981 ldtirsninn ffefskevde ksslktavis ignqllhlke tdtatlrasl aqfeqkwtml
     5041 itqlpdiqek lhqlqmeklp srkaitemis wmnnvehqts dedsvhspss asqvkhllqk
     5101 hkefrmemdy kqwivdfvnq sllqlstcdv eskryertef aehlgemnrq whrvhgmlnr
     5161 kiqhleqlle sitesenkiq ilnnwleaqe erlktlqkpe svisvqklll dcqdienqla
     5221 ikskaldelk qsyltlesga vplledtasr idelfqkrss vltqvnqlkt smqsvlqewk
     5281 iydqlydevn mmtirfwycm ehskpvvlsl etlrcqvenl qslqdeaess egsweklqev
     5341 igklkglcps vaeiieekcq nthkrwtqvn qaiadqlqka qsllqlwkay snahgeaaar
     5401 lkqqeakfqq lanismsgnn laeilppalq dikelqhdvq ktkeaflqns svldrlpqpa
     5461 essthmllpg plhslqraay lekmllvkan efefvlsqfk dfgvrleslk glimheeenl
     5521 drlhqqeken pdsflnhvla ltaqspdieh lnevslklpl sdvavktlqn mnrqwirata
     5581 talercselq giglnekfly ccekwiqlle kieealkvdv anslpelleq qktykmleae
     5641 vsinqtiads yvtqslqlld tteienrpef itefskltdr wqnavqgvrq rkgdvdglvr
     5701 qwqdfttsve nlfrfltdts hllsavkgqe rfslyqtrsl ihelknkeih fqrrrttcal
     5761 tleageklll ttdlktkesv grrisqlqds wkdmepqlae mikqfqstve twdqcekkik
     5821 elksrlqvlk aqsedplpel hedlhnekel ikeleqslas wtqnlkelqt mkadltrhvl
     5881 vedvmvlkeq iehlhrqwed lclrvairkq eiedrlntwv vfneknkelc awlvqmenkv
     5941 lqtadisiee mieklqkdcm eeinlfsenk lqlkqmgdql ikasnksraa eiddklnkin
     6001 drwqhlfdvi gsrvkklket fafiqqldkn msnlrtwlar ieselskpvv ydvcddqeiq
     6061 krlaeqqdlq rdieqhsagv esvfnicdvl lhdsdacane tecdsiqqtt rsldrrwrni
     6121 camsmerrmk ieetwrlwqk flddysrfed wlksaertaa cpnssevlyt sakeelkrfe
     6181 afqrqiherl tqlelinkqy rrlarenrtd tasrlkqmvh egnqrwdnlq rrvtavlrrl
     6241 rhftnqreef egtresilvw ltemdlqltn vehfsesdad dkmrqlngfq qeitlntnki
     6301 dqlivfgeql iqksepldav liedeleelh rycqevfgrv srfhrrltsc tpgledekea
     6361 senetdmedp reiqtdswrk rgeseepssp qslchlvapg hersgcetpv svdsiplewd
     6421 htgdvggsss heedeegpyy salsdveipe npeaylkmtt ktlkassgks isdghswhvp
     6481 dspscpehhy kqmegdrnvp pvppasstpy kppygklllp pgtdggkegp rvlngnpqqe
     6541 dgglagiteq qsgafdrwem iqaqelhnkl kikqnlqqln sdisaittwl kkteaeleml
     6601 kmakppsdiq eielrvkrlq eilkafdtyk alvvsvnvss keflqtespe stelqsrlrq
     6661 lsllweaaqg avdswrgglr qslmqcqgsk trprsdvlff kdfhqlsqnl llwlasaknr
     6721 rqkahvtdpk adprallecr relmqlekel verqpqvdml qeisnsllik ghgedcieae
     6781 ekvhviekkl kqlreqvsqd lmalqgtqnp asplpsfdev dsgdqppats vpaprakqfr
     6841 avrttegeee tesrvpgstr pqrsflsrvv raalplqlll llllllacll psseedysct
     6901 qannfarsfy pmlrytngpp pt
//
LOCUS       XP_005267513            6921 aa            linear   PRI 05-AUG-2025
DEFINITION  nesprin-2 isoform X5 [Homo sapiens].
ACCESSION   XP_005267513
VERSION     XP_005267513.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267456.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..6921
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..6921
                     /product="nesprin-2 isoform X5"
                     /calculated_mol_wt=800355
     Region          28..138
                     /region_name="CH_SYNE2_rpt1"
                     /note="first calponin homology (CH) domain found in
                     synaptic nuclear envelope protein 2; cd21242"
                     /db_xref="CDD:409091"
     Site            order(33,37,89,91..92,95..96,98,107..115,120,122..123,
                     125..126,129..130,133)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409091"
     Region          178..286
                     /region_name="CH_SYNE2_rpt2"
                     /note="second calponin homology (CH) domain found in
                     synaptic nuclear envelope protein 2 (SYNE-2) and similar
                     proteins; cd21244"
                     /db_xref="CDD:409093"
     Site            order(183,187,237,239..240,243..244,246,255..263,270,
                     272..273,275..276,279..280,283)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409093"
     Region          <1418..2014
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          <1868..2417
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          <2338..2712
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          2805..>3389
                     /region_name="CCDC158"
                     /note="Coiled-coil domain-containing protein 158;
                     pfam15921"
                     /db_xref="CDD:464943"
     Region          <3656..>3950
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <3811..4113
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <4496..5321
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          4945..5169
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            5054..5059
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5063..5276
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Region          5123..>5875
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Site            5168..5173
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5178..5384
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cl02488"
                     /db_xref="CDD:413338"
     Site            5275..5280
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5919..6133
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6020..6025
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          6137..6350
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6243..6248
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          6576..6799
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6682..6687
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          <6890..6921
                     /region_name="KASH"
                     /note="Nuclear envelope localization domain; pfam10541"
                     /db_xref="CDD:463142"
     CDS             1..6921
                     /gene="SYNE2"
                     /gene_synonym="EDMD5; KASH2; Nesp2; Nesprin-2; NUA;
                     NUANCE; SYNE-2; TROPH"
                     /coded_by="XM_005267456.2:192..20957"
                     /db_xref="GeneID:23224"
                     /db_xref="HGNC:HGNC:17084"
                     /db_xref="MIM:608442"
ORIGIN      
        1 masspelpte deqgswgidd lhislqaeqe dtqkkaftcw insqlarhts psvisdlftd
       61 ikkghvlldl levlsgqqlp rdkgsntfqc riniehaltf lrnrsiklin ihvtdiidgn
      121 psiilgliwt iilhfhiekl aqtlscnynq pslddvsvvd sspassppak kcskvqarwq
      181 msarkalllw aqeqcatyes vnvtdfkssw rngmaflaii halrpdlidm ksvkhrsnkd
      241 nlreafriae qelkiprlle pedvdvvdpd eksimtyvaq flqyskdapg tgeeaqgkvk
      301 damgwltlqk eklqkllkds endtyfkkyn sllsfmesfn eekksfldvl sikrdldeld
      361 kdhlqlreaw dgldhqinaw kiklnyalpp plhqteawlq eveelmdedl sasqdhsqav
      421 tliqekmtlf kslmdrfehh snilltfenk denhlplvpp nkleemkrri nnilekkfil
      481 llefhyykcl vlglvdevks kldiwnikyg sresvellle dwhkfieeke flarldtsfq
      541 kcgeiyknla gecqninkqy mmvksdvcmy rkniynvkst lqkvlacwat yvenlrllra
      601 cfeetkkeei kevpfetlaq wnlehatlne agnflvevsn dvvgssiske lrrlnkrwrk
      661 lvsktqlemn lplmikkqdq ptfdnsgnil skeekatvef stdmsvelpe nynqnikage
      721 khekeneeft gqlkvakdve kligqveiwe aeaksvldqd dvdtsmeesl khliakgsmf
      781 delmarsedm lqmdiqniss qesfqhvltt glqakiqeak ekvqinvvkl iaalknltdv
      841 spdldirlkm eesqkelesy mmraqqllgq respgelisk hkealiisnt kslakylkav
      901 eelknnvted ikmsleeksr dvcakweslh helslyvqql kidiekgkls dnilklekqi
      961 nkekklirrg rtkglikehe acfseegcly qlnhhmevlr elceelpsqk sqqevkrllk
     1021 dyeqkierll kcaseihmtl qptaggtskn egtittsenr ggdphseapf aksdnqpste
     1081 kameptmkfs lasvlrplqe esimekdysa sinslleryd tyrdilehhl qnnkfritsd
     1141 fsseedrsss clqakltdlq viknetdarw kefeiislkl enhvndikkp fvikerdtlk
     1201 ererelqmtl ntrmesleta lrlvlpveka slllcgsdlp lhkmaiqgfh lidadriyqh
     1261 lrniqdsiak qieicnrlee pgnfvlkelh pfdlhamqni ilkyktqfeg mnhrvqrsed
     1321 tlkaledfla slrtaklsae pvtdlsasdt qvaqentltv knkegeihlm kdkakhldkc
     1381 lkmldmsfkd aergddtsce nlldafsikl sethgygvqe efteenklle acifknnell
     1441 kniqdvqsqi skiglkdptv pavkhrkksl irldkvldey eeekrhlqem anslphfkdg
     1501 rektvnqqcq ntvvlwentk alvtecleqc grvlellkqy qnfksilttl iqkeesvisl
     1561 qasymgkenl kkriaeieiv keefnehlev vdkinqvckn lqfylnkmkt feeppfekea
     1621 niivdrwldi nektedyyen lgralalwdk lfnlknvide wtekalqkme lhqlteedre
     1681 rlkeelqvhe qktsefsrrv aeiqfllqss eiplelqvme ssilnkmehv qkcltgesnc
     1741 halsgstael redldqaktq igmtesllka lspsdsleif tkleeiqqqi lqqkhsmill
     1801 enqigcltpe lselkkqyes vsdlfntkks vlqdhfskll ndqcknfndw fsnikvnlke
     1861 cfessetkks veqklqklsd fltlegrnsk ikqvdsvlkh vkkhlpkahv keliswlvgq
     1921 efelekmesi cqarakeled slqqllrlqd dhrnlrkwlt nqeekwkgme epgektelfc
     1981 qalarkreqf esvaqlnnsl keygfteeee iimeatclmd ryqtllrqls eieeedkllp
     2041 tedqsfndla hdvihwikei keslmvlnss egkmpleeri qkikeiillk pegdarieti
     2101 mkqaesseap lvqktltdis nqwdntlhla stylshqekl llegekylqs kedlrlmlie
     2161 lkkkqeagfa lqhglqekka qlkiykkflk kaqdltsllk elksqgnyll ectknpsfse
     2221 epwleikhlh esllqqlqds vqnldghvre hdsyqvcvtd lnttldnfsk efvsfsdkpv
     2281 dqiaveeklq klqelenrls lqdgtlkkil alaksvkqnt ssvgqkiikd dikslqckqk
     2341 dlenrlasak qemecclnsi lkskrstekk gkftlpgrek qatsdvqest qesaavekle
     2401 edweinkdsa vemamskqls lnaqesmknt ederkvnelq nqpleldtml rneqleeiek
     2461 lytqleakka aikpleqtec lnktetgalv lhnigysaqh ldnllqalit lkknkesqyc
     2521 vlrdfqeyla avessmkall tdkeslkvgp ldsvtyldki kkfiasieke kdslgnlkik
     2581 wenlsnhvtd mdkkllesqi kqlehgweqv eqqiqkkysq qvveydeftt lmnkvqdtei
     2641 slqqqqqhlq lrlkspeera gnqsmialtt dlqatkhgfs vlkgqaelqm kriwgekekk
     2701 nledginnlk kqwetleplh leaenqikkc dirnkmketi lwaknllgel npsipllpdd
     2761 ilsqirkckv thdgilarqq sveslaeevk dkvpslttye gsdlnntled lrnqyqmlvl
     2821 kstqrsqqle fkleersnff aiirkfqlmv qesetliipr vetaateael khhhvtleas
     2881 qkelqeidsg isthlqeltn iyeelnvfer lfledqlknl kirtnriqrf iqntcneveh
     2941 kikfcrqfhe ktsalqeead siqrnellln qevnkgvkee iynlkdrlta ikccilqvlk
     3001 lkkvfdyigl nwdfsqldql qtqvfekeke leekikqldt feeehgkyqa llskmraidl
     3061 qikkmtevvl kapdsspesr rlnaqilsqr iekakclcde iikklnenkt fddsfkekei
     3121 lqiklnaeen dklykvlqnm vlelspkeld ekncqdklet slhvlnqiks qlqqpllinl
     3181 eikhiqnekd nceafqeqvw aemcsikavt aiekqreens seasdvetkl refedlqmql
     3241 ntsidlrtnv lndayenltr ykeavtrave sitsleaiii pyrvdvgnpe eslemplrkq
     3301 eelestvahi qdlteklgmi sspeaklqlq ytlqelvskn samkeafkaq eteaerylen
     3361 ykcyrkmeed iytnlskmet vlgqsmsslp lsyrealerl eqskalvsnl istkeelmkl
     3421 rqilrllrlr ctendgicll kivsalwekw lslleaakew emwceelkqe wkfvseeier
     3481 eaiildnlqe elpeisktke aatteelsel ldclcqygen vekqqllltl llqrirsiqn
     3541 vpessgavet vpafqeitsm kercnkllqk vqknkelvqt eiqerhsftk eiialknffq
     3601 qtttsfqnma fqdhpekseq feelqsilkk gkltfenime klrikysemy tivpaeiesq
     3661 veecrkaled idekisnevl ksspsyamrr kieeinnglh nvekmlqqks kniekaqeiq
     3721 kkmwdeldlw hsklneldse vqdiveqdpg qaqewmdnlm ipfqqyqqvs qraecrtsql
     3781 nkatvkmeey sdllksteaw ientshllan padydslrtl shhastvqma ledseqkhnl
     3841 lhsifmdled lsiifetdel tqsiqelsnq vtalqqkime slpqiqrmad dvvaiesevk
     3901 smekrvskik tillskeifd fspeehlkhg evilenirpm kktiaeivsy qvelrlpqtg
     3961 mkplpvfqrt nqllqdikll envtqeqnel lkvvikqtne wdeeienlkq ilnnysaqfs
     4021 lehmspdqad klpqlqgeie rmekqilsln qrkedllvdl katvlnlhqh lkqeqegver
     4081 drlpavtsee ggvaerdase rklnrrgsms ylaaveeeve essvksdngd ekaepspqsw
     4141 sslwkhdkdm eedrassssg tivqeaygki stsdnsmaqi ltpdslnteq gpecslrpnq
     4201 teegttppie adtldssdaq ggleprvekt rpeptevlha cktqvaelel wlqqanvave
     4261 petlnadmqq vleqqlvgcq amlteiehkv aflletckdq glgdngatqh eaealslklk
     4321 tvkcnlekvq mmlqekhsed qhptilkkss epehqealqp vnlselesiv terpqfsrqk
     4381 dfqqqqvlel kpmeqkdfik fiefnakkmw pqycqhdndt tqessasnqa sspendvpds
     4441 ilspqgqngd kwqylhhels skiklplpql vepqvstnmg ilpsvtmynf ryptteelkt
     4501 yttqledlrq easnlqtqen mteeayinld kklfelfltl sqclssveem lemprlyred
     4561 gsgqqvhyet lalelkklyl alsdkkgdll kamtwpgent nlllecfdnl qvclehtqaa
     4621 avcrskslka gldynrsyqn eikrlyhqli ksktslqqsl neisgqsvae qlqkadaytv
     4681 elenaesrva klrdegerlh lpyallqevy kledvldsmw gmlrarytel sspfvtesqq
     4741 dallqgmvel vkigkeklah ghlkqtkskv alqaqienhk vffqklvadm lliqaysaki
     4801 lpsllqnret fwaeqvtevk ileeksrqcg mklqsllqkw eefdenyasl ekdleilist
     4861 lpsvslveet eerlverisf yqqikrnigg kharlyqtln egkqlvasvs cpelegqiak
     4921 leeqwlslnk kidhelhrlq allkhllsyn rdsdqltkwl essqhtlnyw keqslnvsqd
     4981 ldtirsninn ffefskevde ksslktavis ignqllhlke tdtatlrasl aqfeqkwtml
     5041 itqlpdiqek lhqlqmeklp srkaitemis wmnnvehqts dedsvhspss asqvkhllqk
     5101 hkefrmemdy kqwivdfvnq sllqlstcdv eskryertef aehlgemnrq whrvhgmlnr
     5161 kiqhleqlle sitesenkiq ilnnwleaqe erlktlqkpe svisvqklll dcqdienqla
     5221 ikskaldelk qsyltlesga vplledtasr idelfqkrss vltqvnqlkt smqsvlqewk
     5281 iydqlydevn mmtirfwycm ehskpvvlsl etlrcqvenl qslqdeaess egsweklqev
     5341 igklkglcps vaeiieekcq nthkrwtqvn qaiadqlqka qsllqlwkay snahgeaaar
     5401 lkqqeakfqq lanismsgnn laeilppalq dikelqhdvq ktkeaflqns svldrlpqpa
     5461 essthmllpg plhslqraay lekmllvkan efefvlsqfk dfgvrleslk glimheeenl
     5521 drlhqqeken pdsflnhvla ltaqspdieh lnevslklpl sdvavktlqn mnrqwirata
     5581 talercselq giglnekfly ccekwiqlle kieealkvdv anslpelleq qktykmleae
     5641 vsinqtiads yvtqslqlld tteienrpef itefskltdr wqnavqgvrq rkgdvdglvr
     5701 qwqdfttsve nlfrfltdts hllsavkgqe rfslyqtrsl ihelknkeih fqrrrttcal
     5761 tleageklll ttdlktkesv grrisqlqds wkdmepqlae mikqfqstve twdqcekkik
     5821 elksrlqvlk aqsedplpel hedlhnekel ikeleqslas wtqnlkelqt mkadltrhvl
     5881 vedvmvlkeq iehlhrqwed lclrvairkq eiedrlntwv vfneknkelc awlvqmenkv
     5941 lqtadisiee mieklqkdcm eeinlfsenk lqlkqmgdql ikasnksraa eiddklnkin
     6001 drwqhlfdvi gsrvkklket fafiqqldkn msnlrtwlar ieselskpvv ydvcddqeiq
     6061 krlaeqqdlq rdieqhsagv esvfnicdvl lhdsdacane tecdsiqqtt rsldrrwrni
     6121 camsmerrmk ieetwrlwqk flddysrfed wlksaertaa cpnssevlyt sakeelkrfe
     6181 afqrqiherl tqlelinkqy rrlarenrtd tasrlkqmvh egnqrwdnlq rrvtavlrrl
     6241 rhftnqreef egtresilvw ltemdlqltn vehfsesdad dkmrqlngfq qeitlntnki
     6301 dqlivfgeql iqksepldav liedeleelh rycqevfgrv srfhrrltsc tpgledekea
     6361 senetdmedp reiqtdswrk rgeseepssp qslchlvapg hersgcetpv svdsiplewd
     6421 htgdvggsss heedeegpyy salsdveipe npeaylkmtt ktlkassgks isdghswhvp
     6481 dspscpehhy kqmegdrnvp pvppasstpy kppygklllp pgtdggkegp rvlngnpqqe
     6541 dgglagiteq qsgafdrwem iqaqelhnkl kikqnlqqln sdisaittwl kkteaeleml
     6601 kmakppsdiq eielrvkrlq eilkafdtyk alvvsvnvss keflqtespe stelqsrlrq
     6661 lsllweaaqg avdswrgglr qslmqcqgsk trprsdvlff kdfhqlsqnl llwlasaknr
     6721 rqkahvtdpk adprallecr relmqlekel verqpqvdml qeisnsllik ghgedcieae
     6781 ekvhviekkl kqlreqvsqd lmalqgtqnp asplpsfdev dsgdqppats vpaprakfra
     6841 vrttegeeet esrvpgstrp qrsflsrvvr aalplqllll lllllacllp sseedysctq
     6901 annfarsfyp mlrytngppp t
//
LOCUS       XP_011534882            6921 aa            linear   PRI 05-AUG-2025
DEFINITION  nesprin-2 isoform X6 [Homo sapiens].
ACCESSION   XP_011534882
VERSION     XP_011534882.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536580.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..6921
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..6921
                     /product="nesprin-2 isoform X6"
                     /calculated_mol_wt=800319
     Region          28..138
                     /region_name="CH_SYNE2_rpt1"
                     /note="first calponin homology (CH) domain found in
                     synaptic nuclear envelope protein 2; cd21242"
                     /db_xref="CDD:409091"
     Site            order(33,37,89,91..92,95..96,98,107..115,120,122..123,
                     125..126,129..130,133)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409091"
     Region          178..286
                     /region_name="CH_SYNE2_rpt2"
                     /note="second calponin homology (CH) domain found in
                     synaptic nuclear envelope protein 2 (SYNE-2) and similar
                     proteins; cd21244"
                     /db_xref="CDD:409093"
     Site            order(183,187,237,239..240,243..244,246,255..263,270,
                     272..273,275..276,279..280,283)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409093"
     Region          <1418..2014
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          <1868..>2369
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          <2338..2712
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          2805..>3389
                     /region_name="CCDC158"
                     /note="Coiled-coil domain-containing protein 158;
                     pfam15921"
                     /db_xref="CDD:464943"
     Region          <3656..>3950
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <3811..4113
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <4496..5321
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          4945..5169
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            5054..5059
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5063..5276
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Region          5123..>5875
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Site            5168..5173
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5178..5384
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cl02488"
                     /db_xref="CDD:413338"
     Site            5275..5280
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5919..6133
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6020..6025
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          6137..6350
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6243..6248
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          6590..6799
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6696..6701
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          <6890..6921
                     /region_name="KASH"
                     /note="Nuclear envelope localization domain; pfam10541"
                     /db_xref="CDD:463142"
     CDS             1..6921
                     /gene="SYNE2"
                     /gene_synonym="EDMD5; KASH2; Nesp2; Nesprin-2; NUA;
                     NUANCE; SYNE-2; TROPH"
                     /coded_by="XM_011536580.3:192..20957"
                     /db_xref="GeneID:23224"
                     /db_xref="HGNC:HGNC:17084"
                     /db_xref="MIM:608442"
ORIGIN      
        1 masspelpte deqgswgidd lhislqaeqe dtqkkaftcw insqlarhts psvisdlftd
       61 ikkghvlldl levlsgqqlp rdkgsntfqc riniehaltf lrnrsiklin ihvtdiidgn
      121 psiilgliwt iilhfhiekl aqtlscnynq pslddvsvvd sspassppak kcskvqarwq
      181 msarkalllw aqeqcatyes vnvtdfkssw rngmaflaii halrpdlidm ksvkhrsnkd
      241 nlreafriae qelkiprlle pedvdvvdpd eksimtyvaq flqyskdapg tgeeaqgkvk
      301 damgwltlqk eklqkllkds endtyfkkyn sllsfmesfn eekksfldvl sikrdldeld
      361 kdhlqlreaw dgldhqinaw kiklnyalpp plhqteawlq eveelmdedl sasqdhsqav
      421 tliqekmtlf kslmdrfehh snilltfenk denhlplvpp nkleemkrri nnilekkfil
      481 llefhyykcl vlglvdevks kldiwnikyg sresvellle dwhkfieeke flarldtsfq
      541 kcgeiyknla gecqninkqy mmvksdvcmy rkniynvkst lqkvlacwat yvenlrllra
      601 cfeetkkeei kevpfetlaq wnlehatlne agnflvevsn dvvgssiske lrrlnkrwrk
      661 lvsktqlemn lplmikkqdq ptfdnsgnil skeekatvef stdmsvelpe nynqnikage
      721 khekeneeft gqlkvakdve kligqveiwe aeaksvldqd dvdtsmeesl khliakgsmf
      781 delmarsedm lqmdiqniss qesfqhvltt glqakiqeak ekvqinvvkl iaalknltdv
      841 spdldirlkm eesqkelesy mmraqqllgq respgelisk hkealiisnt kslakylkav
      901 eelknnvted ikmsleeksr dvcakweslh helslyvqql kidiekgkls dnilklekqi
      961 nkekklirrg rtkglikehe acfseegcly qlnhhmevlr elceelpsqk sqqevkrllk
     1021 dyeqkierll kcaseihmtl qptaggtskn egtittsenr ggdphseapf aksdnqpste
     1081 kameptmkfs lasvlrplqe esimekdysa sinslleryd tyrdilehhl qnnkfritsd
     1141 fsseedrsss clqakltdlq viknetdarw kefeiislkl enhvndikkp fvikerdtlk
     1201 ererelqmtl ntrmesleta lrlvlpveka slllcgsdlp lhkmaiqgfh lidadriyqh
     1261 lrniqdsiak qieicnrlee pgnfvlkelh pfdlhamqni ilkyktqfeg mnhrvqrsed
     1321 tlkaledfla slrtaklsae pvtdlsasdt qvaqentltv knkegeihlm kdkakhldkc
     1381 lkmldmsfkd aergddtsce nlldafsikl sethgygvqe efteenklle acifknnell
     1441 kniqdvqsqi skiglkdptv pavkhrkksl irldkvldey eeekrhlqem anslphfkdg
     1501 rektvnqqcq ntvvlwentk alvtecleqc grvlellkqy qnfksilttl iqkeesvisl
     1561 qasymgkenl kkriaeieiv keefnehlev vdkinqvckn lqfylnkmkt feeppfekea
     1621 niivdrwldi nektedyyen lgralalwdk lfnlknvide wtekalqkme lhqlteedre
     1681 rlkeelqvhe qktsefsrrv aeiqfllqss eiplelqvme ssilnkmehv qkcltgesnc
     1741 halsgstael redldqaktq igmtesllka lspsdsleif tkleeiqqqi lqqkhsmill
     1801 enqigcltpe lselkkqyes vsdlfntkks vlqdhfskll ndqcknfndw fsnikvnlke
     1861 cfessetkks veqklqklsd fltlegrnsk ikqvdsvlkh vkkhlpkahv keliswlvgq
     1921 efelekmesi cqarakeled slqqllrlqd dhrnlrkwlt nqeekwkgme epgektelfc
     1981 qalarkreqf esvaqlnnsl keygfteeee iimeatclmd ryqtllrqls eieeedkllp
     2041 tedqsfndla hdvihwikei keslmvlnss egkmpleeri qkikeiillk pegdarieti
     2101 mkqaesseap lvqktltdis nqwdntlhla stylshqekl llegekylqs kedlrlmlie
     2161 lkkkqeagfa lqhglqekka qlkiykkflk kaqdltsllk elksqgnyll ectknpsfse
     2221 epwleikhlh esllqqlqds vqnldghvre hdsyqvcvtd lnttldnfsk efvsfsdkpv
     2281 dqiaveeklq klqelenrls lqdgtlkkil alaksvkqnt ssvgqkiikd dikslqckqk
     2341 dlenrlasak qemecclnsi lkskrstekk gkftlpgrek qatsdvqest qesaavekle
     2401 edweinkdsa vemamskqls lnaqesmknt ederkvnelq nqpleldtml rneqleeiek
     2461 lytqleakka aikpleqtec lnktetgalv lhnigysaqh ldnllqalit lkknkesqyc
     2521 vlrdfqeyla avessmkall tdkeslkvgp ldsvtyldki kkfiasieke kdslgnlkik
     2581 wenlsnhvtd mdkkllesqi kqlehgweqv eqqiqkkysq qvveydeftt lmnkvqdtei
     2641 slqqqqqhlq lrlkspeera gnqsmialtt dlqatkhgfs vlkgqaelqm kriwgekekk
     2701 nledginnlk kqwetleplh leaenqikkc dirnkmketi lwaknllgel npsipllpdd
     2761 ilsqirkckv thdgilarqq sveslaeevk dkvpslttye gsdlnntled lrnqyqmlvl
     2821 kstqrsqqle fkleersnff aiirkfqlmv qesetliipr vetaateael khhhvtleas
     2881 qkelqeidsg isthlqeltn iyeelnvfer lfledqlknl kirtnriqrf iqntcneveh
     2941 kikfcrqfhe ktsalqeead siqrnellln qevnkgvkee iynlkdrlta ikccilqvlk
     3001 lkkvfdyigl nwdfsqldql qtqvfekeke leekikqldt feeehgkyqa llskmraidl
     3061 qikkmtevvl kapdsspesr rlnaqilsqr iekakclcde iikklnenkt fddsfkekei
     3121 lqiklnaeen dklykvlqnm vlelspkeld ekncqdklet slhvlnqiks qlqqpllinl
     3181 eikhiqnekd nceafqeqvw aemcsikavt aiekqreens seasdvetkl refedlqmql
     3241 ntsidlrtnv lndayenltr ykeavtrave sitsleaiii pyrvdvgnpe eslemplrkq
     3301 eelestvahi qdlteklgmi sspeaklqlq ytlqelvskn samkeafkaq eteaerylen
     3361 ykcyrkmeed iytnlskmet vlgqsmsslp lsyrealerl eqskalvsnl istkeelmkl
     3421 rqilrllrlr ctendgicll kivsalwekw lslleaakew emwceelkqe wkfvseeier
     3481 eaiildnlqe elpeisktke aatteelsel ldclcqygen vekqqllltl llqrirsiqn
     3541 vpessgavet vpafqeitsm kercnkllqk vqknkelvqt eiqerhsftk eiialknffq
     3601 qtttsfqnma fqdhpekseq feelqsilkk gkltfenime klrikysemy tivpaeiesq
     3661 veecrkaled idekisnevl ksspsyamrr kieeinnglh nvekmlqqks kniekaqeiq
     3721 kkmwdeldlw hsklneldse vqdiveqdpg qaqewmdnlm ipfqqyqqvs qraecrtsql
     3781 nkatvkmeey sdllksteaw ientshllan padydslrtl shhastvqma ledseqkhnl
     3841 lhsifmdled lsiifetdel tqsiqelsnq vtalqqkime slpqiqrmad dvvaiesevk
     3901 smekrvskik tillskeifd fspeehlkhg evilenirpm kktiaeivsy qvelrlpqtg
     3961 mkplpvfqrt nqllqdikll envtqeqnel lkvvikqtne wdeeienlkq ilnnysaqfs
     4021 lehmspdqad klpqlqgeie rmekqilsln qrkedllvdl katvlnlhqh lkqeqegver
     4081 drlpavtsee ggvaerdase rklnrrgsms ylaaveeeve essvksdngd ekaepspqsw
     4141 sslwkhdkdm eedrassssg tivqeaygki stsdnsmaqi ltpdslnteq gpecslrpnq
     4201 teegttppie adtldssdaq ggleprvekt rpeptevlha cktqvaelel wlqqanvave
     4261 petlnadmqq vleqqlvgcq amlteiehkv aflletckdq glgdngatqh eaealslklk
     4321 tvkcnlekvq mmlqekhsed qhptilkkss epehqealqp vnlselesiv terpqfsrqk
     4381 dfqqqqvlel kpmeqkdfik fiefnakkmw pqycqhdndt tqessasnqa sspendvpds
     4441 ilspqgqngd kwqylhhels skiklplpql vepqvstnmg ilpsvtmynf ryptteelkt
     4501 yttqledlrq easnlqtqen mteeayinld kklfelfltl sqclssveem lemprlyred
     4561 gsgqqvhyet lalelkklyl alsdkkgdll kamtwpgent nlllecfdnl qvclehtqaa
     4621 avcrskslka gldynrsyqn eikrlyhqli ksktslqqsl neisgqsvae qlqkadaytv
     4681 elenaesrva klrdegerlh lpyallqevy kledvldsmw gmlrarytel sspfvtesqq
     4741 dallqgmvel vkigkeklah ghlkqtkskv alqaqienhk vffqklvadm lliqaysaki
     4801 lpsllqnret fwaeqvtevk ileeksrqcg mklqsllqkw eefdenyasl ekdleilist
     4861 lpsvslveet eerlverisf yqqikrnigg kharlyqtln egkqlvasvs cpelegqiak
     4921 leeqwlslnk kidhelhrlq allkhllsyn rdsdqltkwl essqhtlnyw keqslnvsqd
     4981 ldtirsninn ffefskevde ksslktavis ignqllhlke tdtatlrasl aqfeqkwtml
     5041 itqlpdiqek lhqlqmeklp srkaitemis wmnnvehqts dedsvhspss asqvkhllqk
     5101 hkefrmemdy kqwivdfvnq sllqlstcdv eskryertef aehlgemnrq whrvhgmlnr
     5161 kiqhleqlle sitesenkiq ilnnwleaqe erlktlqkpe svisvqklll dcqdienqla
     5221 ikskaldelk qsyltlesga vplledtasr idelfqkrss vltqvnqlkt smqsvlqewk
     5281 iydqlydevn mmtirfwycm ehskpvvlsl etlrcqvenl qslqdeaess egsweklqev
     5341 igklkglcps vaeiieekcq nthkrwtqvn qaiadqlqka qsllqlwkay snahgeaaar
     5401 lkqqeakfqq lanismsgnn laeilppalq dikelqhdvq ktkeaflqns svldrlpqpa
     5461 essthmllpg plhslqraay lekmllvkan efefvlsqfk dfgvrleslk glimheeenl
     5521 drlhqqeken pdsflnhvla ltaqspdieh lnevslklpl sdvavktlqn mnrqwirata
     5581 talercselq giglnekfly ccekwiqlle kieealkvdv anslpelleq qktykmleae
     5641 vsinqtiads yvtqslqlld tteienrpef itefskltdr wqnavqgvrq rkgdvdglvr
     5701 qwqdfttsve nlfrfltdts hllsavkgqe rfslyqtrsl ihelknkeih fqrrrttcal
     5761 tleageklll ttdlktkesv grrisqlqds wkdmepqlae mikqfqstve twdqcekkik
     5821 elksrlqvlk aqsedplpel hedlhnekel ikeleqslas wtqnlkelqt mkadltrhvl
     5881 vedvmvlkeq iehlhrqwed lclrvairkq eiedrlntwv vfneknkelc awlvqmenkv
     5941 lqtadisiee mieklqkdcm eeinlfsenk lqlkqmgdql ikasnksraa eiddklnkin
     6001 drwqhlfdvi gsrvkklket fafiqqldkn msnlrtwlar ieselskpvv ydvcddqeiq
     6061 krlaeqqdlq rdieqhsagv esvfnicdvl lhdsdacane tecdsiqqtt rsldrrwrni
     6121 camsmerrmk ieetwrlwqk flddysrfed wlksaertaa cpnssevlyt sakeelkrfe
     6181 afqrqiherl tqlelinkqy rrlarenrtd tasrlkqmvh egnqrwdnlq rrvtavlrrl
     6241 rhftnqreef egtresilvw ltemdlqltn vehfsesdad dkmrqlngfq qeitlntnki
     6301 dqlivfgeql iqksepldav liedeleelh rycqevfgrv srfhrrltsc tpgledekea
     6361 senetdmedp reiqtdswrk rgeseepssp qslchlvapg hersgcetpv svdsiplewd
     6421 htgdvggsss heedeegpyy salsdveipe npeaylkmtt ktlkassgks isdghswhvp
     6481 dspscpehhy kqmegdrnvp pvppasstpy kppygklllp pgtdggkegp rvlngnpqqe
     6541 dgglagiteq qsgtacnwqs sreaeygafd rwemiqaqel hnklkikqnl qqlnsdisai
     6601 ttwlkkteae lemlkmakpp sdiqeielrv krlqeilkaf dtykalvvsv nvsskeflqt
     6661 espestelqs rlrqlsllwe aaqgavdswr gglrqslmqc qdfhqlsqnl llwlasaknr
     6721 rqkahvtdpk adprallecr relmqlekel verqpqvdml qeisnsllik ghgedcieae
     6781 ekvhviekkl kqlreqvsqd lmalqgtqnp asplpsfdev dsgdqppats vpaprakfra
     6841 vrttegeeet esrvpgstrp qrsflsrvvr aalplqllll lllllacllp sseedysctq
     6901 annfarsfyp mlrytngppp t
//
LOCUS       XP_011534883            6913 aa            linear   PRI 05-AUG-2025
DEFINITION  nesprin-2 isoform X7 [Homo sapiens].
ACCESSION   XP_011534883
VERSION     XP_011534883.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536581.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..6913
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..6913
                     /product="nesprin-2 isoform X7"
                     /calculated_mol_wt=799519
     Region          28..138
                     /region_name="CH_SYNE2_rpt1"
                     /note="first calponin homology (CH) domain found in
                     synaptic nuclear envelope protein 2; cd21242"
                     /db_xref="CDD:409091"
     Site            order(33,37,89,91..92,95..96,98,107..115,120,122..123,
                     125..126,129..130,133)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409091"
     Region          178..286
                     /region_name="CH_SYNE2_rpt2"
                     /note="second calponin homology (CH) domain found in
                     synaptic nuclear envelope protein 2 (SYNE-2) and similar
                     proteins; cd21244"
                     /db_xref="CDD:409093"
     Site            order(183,187,237,239..240,243..244,246,255..263,270,
                     272..273,275..276,279..280,283)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409093"
     Region          <1418..2014
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          <1868..>2369
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          <2338..2712
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          2805..>3389
                     /region_name="CCDC158"
                     /note="Coiled-coil domain-containing protein 158;
                     pfam15921"
                     /db_xref="CDD:464943"
     Region          <3656..>3950
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <3811..4113
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <4496..5321
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          4945..5169
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            5054..5059
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5063..5276
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Region          5123..>5875
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Site            5168..5173
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5178..5384
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cl02488"
                     /db_xref="CDD:413338"
     Site            5275..5280
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5919..6133
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6020..6025
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          6137..6350
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6243..6248
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          6567..6790
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6673..6678
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          <6882..6913
                     /region_name="KASH"
                     /note="Nuclear envelope localization domain; pfam10541"
                     /db_xref="CDD:463142"
     CDS             1..6913
                     /gene="SYNE2"
                     /gene_synonym="EDMD5; KASH2; Nesp2; Nesprin-2; NUA;
                     NUANCE; SYNE-2; TROPH"
                     /coded_by="XM_011536581.2:192..20933"
                     /db_xref="GeneID:23224"
                     /db_xref="HGNC:HGNC:17084"
                     /db_xref="MIM:608442"
ORIGIN      
        1 masspelpte deqgswgidd lhislqaeqe dtqkkaftcw insqlarhts psvisdlftd
       61 ikkghvlldl levlsgqqlp rdkgsntfqc riniehaltf lrnrsiklin ihvtdiidgn
      121 psiilgliwt iilhfhiekl aqtlscnynq pslddvsvvd sspassppak kcskvqarwq
      181 msarkalllw aqeqcatyes vnvtdfkssw rngmaflaii halrpdlidm ksvkhrsnkd
      241 nlreafriae qelkiprlle pedvdvvdpd eksimtyvaq flqyskdapg tgeeaqgkvk
      301 damgwltlqk eklqkllkds endtyfkkyn sllsfmesfn eekksfldvl sikrdldeld
      361 kdhlqlreaw dgldhqinaw kiklnyalpp plhqteawlq eveelmdedl sasqdhsqav
      421 tliqekmtlf kslmdrfehh snilltfenk denhlplvpp nkleemkrri nnilekkfil
      481 llefhyykcl vlglvdevks kldiwnikyg sresvellle dwhkfieeke flarldtsfq
      541 kcgeiyknla gecqninkqy mmvksdvcmy rkniynvkst lqkvlacwat yvenlrllra
      601 cfeetkkeei kevpfetlaq wnlehatlne agnflvevsn dvvgssiske lrrlnkrwrk
      661 lvsktqlemn lplmikkqdq ptfdnsgnil skeekatvef stdmsvelpe nynqnikage
      721 khekeneeft gqlkvakdve kligqveiwe aeaksvldqd dvdtsmeesl khliakgsmf
      781 delmarsedm lqmdiqniss qesfqhvltt glqakiqeak ekvqinvvkl iaalknltdv
      841 spdldirlkm eesqkelesy mmraqqllgq respgelisk hkealiisnt kslakylkav
      901 eelknnvted ikmsleeksr dvcakweslh helslyvqql kidiekgkls dnilklekqi
      961 nkekklirrg rtkglikehe acfseegcly qlnhhmevlr elceelpsqk sqqevkrllk
     1021 dyeqkierll kcaseihmtl qptaggtskn egtittsenr ggdphseapf aksdnqpste
     1081 kameptmkfs lasvlrplqe esimekdysa sinslleryd tyrdilehhl qnnkfritsd
     1141 fsseedrsss clqakltdlq viknetdarw kefeiislkl enhvndikkp fvikerdtlk
     1201 ererelqmtl ntrmesleta lrlvlpveka slllcgsdlp lhkmaiqgfh lidadriyqh
     1261 lrniqdsiak qieicnrlee pgnfvlkelh pfdlhamqni ilkyktqfeg mnhrvqrsed
     1321 tlkaledfla slrtaklsae pvtdlsasdt qvaqentltv knkegeihlm kdkakhldkc
     1381 lkmldmsfkd aergddtsce nlldafsikl sethgygvqe efteenklle acifknnell
     1441 kniqdvqsqi skiglkdptv pavkhrkksl irldkvldey eeekrhlqem anslphfkdg
     1501 rektvnqqcq ntvvlwentk alvtecleqc grvlellkqy qnfksilttl iqkeesvisl
     1561 qasymgkenl kkriaeieiv keefnehlev vdkinqvckn lqfylnkmkt feeppfekea
     1621 niivdrwldi nektedyyen lgralalwdk lfnlknvide wtekalqkme lhqlteedre
     1681 rlkeelqvhe qktsefsrrv aeiqfllqss eiplelqvme ssilnkmehv qkcltgesnc
     1741 halsgstael redldqaktq igmtesllka lspsdsleif tkleeiqqqi lqqkhsmill
     1801 enqigcltpe lselkkqyes vsdlfntkks vlqdhfskll ndqcknfndw fsnikvnlke
     1861 cfessetkks veqklqklsd fltlegrnsk ikqvdsvlkh vkkhlpkahv keliswlvgq
     1921 efelekmesi cqarakeled slqqllrlqd dhrnlrkwlt nqeekwkgme epgektelfc
     1981 qalarkreqf esvaqlnnsl keygfteeee iimeatclmd ryqtllrqls eieeedkllp
     2041 tedqsfndla hdvihwikei keslmvlnss egkmpleeri qkikeiillk pegdarieti
     2101 mkqaesseap lvqktltdis nqwdntlhla stylshqekl llegekylqs kedlrlmlie
     2161 lkkkqeagfa lqhglqekka qlkiykkflk kaqdltsllk elksqgnyll ectknpsfse
     2221 epwleikhlh esllqqlqds vqnldghvre hdsyqvcvtd lnttldnfsk efvsfsdkpv
     2281 dqiaveeklq klqelenrls lqdgtlkkil alaksvkqnt ssvgqkiikd dikslqckqk
     2341 dlenrlasak qemecclnsi lkskrstekk gkftlpgrek qatsdvqest qesaavekle
     2401 edweinkdsa vemamskqls lnaqesmknt ederkvnelq nqpleldtml rneqleeiek
     2461 lytqleakka aikpleqtec lnktetgalv lhnigysaqh ldnllqalit lkknkesqyc
     2521 vlrdfqeyla avessmkall tdkeslkvgp ldsvtyldki kkfiasieke kdslgnlkik
     2581 wenlsnhvtd mdkkllesqi kqlehgweqv eqqiqkkysq qvveydeftt lmnkvqdtei
     2641 slqqqqqhlq lrlkspeera gnqsmialtt dlqatkhgfs vlkgqaelqm kriwgekekk
     2701 nledginnlk kqwetleplh leaenqikkc dirnkmketi lwaknllgel npsipllpdd
     2761 ilsqirkckv thdgilarqq sveslaeevk dkvpslttye gsdlnntled lrnqyqmlvl
     2821 kstqrsqqle fkleersnff aiirkfqlmv qesetliipr vetaateael khhhvtleas
     2881 qkelqeidsg isthlqeltn iyeelnvfer lfledqlknl kirtnriqrf iqntcneveh
     2941 kikfcrqfhe ktsalqeead siqrnellln qevnkgvkee iynlkdrlta ikccilqvlk
     3001 lkkvfdyigl nwdfsqldql qtqvfekeke leekikqldt feeehgkyqa llskmraidl
     3061 qikkmtevvl kapdsspesr rlnaqilsqr iekakclcde iikklnenkt fddsfkekei
     3121 lqiklnaeen dklykvlqnm vlelspkeld ekncqdklet slhvlnqiks qlqqpllinl
     3181 eikhiqnekd nceafqeqvw aemcsikavt aiekqreens seasdvetkl refedlqmql
     3241 ntsidlrtnv lndayenltr ykeavtrave sitsleaiii pyrvdvgnpe eslemplrkq
     3301 eelestvahi qdlteklgmi sspeaklqlq ytlqelvskn samkeafkaq eteaerylen
     3361 ykcyrkmeed iytnlskmet vlgqsmsslp lsyrealerl eqskalvsnl istkeelmkl
     3421 rqilrllrlr ctendgicll kivsalwekw lslleaakew emwceelkqe wkfvseeier
     3481 eaiildnlqe elpeisktke aatteelsel ldclcqygen vekqqllltl llqrirsiqn
     3541 vpessgavet vpafqeitsm kercnkllqk vqknkelvqt eiqerhsftk eiialknffq
     3601 qtttsfqnma fqdhpekseq feelqsilkk gkltfenime klrikysemy tivpaeiesq
     3661 veecrkaled idekisnevl ksspsyamrr kieeinnglh nvekmlqqks kniekaqeiq
     3721 kkmwdeldlw hsklneldse vqdiveqdpg qaqewmdnlm ipfqqyqqvs qraecrtsql
     3781 nkatvkmeey sdllksteaw ientshllan padydslrtl shhastvqma ledseqkhnl
     3841 lhsifmdled lsiifetdel tqsiqelsnq vtalqqkime slpqiqrmad dvvaiesevk
     3901 smekrvskik tillskeifd fspeehlkhg evilenirpm kktiaeivsy qvelrlpqtg
     3961 mkplpvfqrt nqllqdikll envtqeqnel lkvvikqtne wdeeienlkq ilnnysaqfs
     4021 lehmspdqad klpqlqgeie rmekqilsln qrkedllvdl katvlnlhqh lkqeqegver
     4081 drlpavtsee ggvaerdase rklnrrgsms ylaaveeeve essvksdngd ekaepspqsw
     4141 sslwkhdkdm eedrassssg tivqeaygki stsdnsmaqi ltpdslnteq gpecslrpnq
     4201 teegttppie adtldssdaq ggleprvekt rpeptevlha cktqvaelel wlqqanvave
     4261 petlnadmqq vleqqlvgcq amlteiehkv aflletckdq glgdngatqh eaealslklk
     4321 tvkcnlekvq mmlqekhsed qhptilkkss epehqealqp vnlselesiv terpqfsrqk
     4381 dfqqqqvlel kpmeqkdfik fiefnakkmw pqycqhdndt tqessasnqa sspendvpds
     4441 ilspqgqngd kwqylhhels skiklplpql vepqvstnmg ilpsvtmynf ryptteelkt
     4501 yttqledlrq easnlqtqen mteeayinld kklfelfltl sqclssveem lemprlyred
     4561 gsgqqvhyet lalelkklyl alsdkkgdll kamtwpgent nlllecfdnl qvclehtqaa
     4621 avcrskslka gldynrsyqn eikrlyhqli ksktslqqsl neisgqsvae qlqkadaytv
     4681 elenaesrva klrdegerlh lpyallqevy kledvldsmw gmlrarytel sspfvtesqq
     4741 dallqgmvel vkigkeklah ghlkqtkskv alqaqienhk vffqklvadm lliqaysaki
     4801 lpsllqnret fwaeqvtevk ileeksrqcg mklqsllqkw eefdenyasl ekdleilist
     4861 lpsvslveet eerlverisf yqqikrnigg kharlyqtln egkqlvasvs cpelegqiak
     4921 leeqwlslnk kidhelhrlq allkhllsyn rdsdqltkwl essqhtlnyw keqslnvsqd
     4981 ldtirsninn ffefskevde ksslktavis ignqllhlke tdtatlrasl aqfeqkwtml
     5041 itqlpdiqek lhqlqmeklp srkaitemis wmnnvehqts dedsvhspss asqvkhllqk
     5101 hkefrmemdy kqwivdfvnq sllqlstcdv eskryertef aehlgemnrq whrvhgmlnr
     5161 kiqhleqlle sitesenkiq ilnnwleaqe erlktlqkpe svisvqklll dcqdienqla
     5221 ikskaldelk qsyltlesga vplledtasr idelfqkrss vltqvnqlkt smqsvlqewk
     5281 iydqlydevn mmtirfwycm ehskpvvlsl etlrcqvenl qslqdeaess egsweklqev
     5341 igklkglcps vaeiieekcq nthkrwtqvn qaiadqlqka qsllqlwkay snahgeaaar
     5401 lkqqeakfqq lanismsgnn laeilppalq dikelqhdvq ktkeaflqns svldrlpqpa
     5461 essthmllpg plhslqraay lekmllvkan efefvlsqfk dfgvrleslk glimheeenl
     5521 drlhqqeken pdsflnhvla ltaqspdieh lnevslklpl sdvavktlqn mnrqwirata
     5581 talercselq giglnekfly ccekwiqlle kieealkvdv anslpelleq qktykmleae
     5641 vsinqtiads yvtqslqlld tteienrpef itefskltdr wqnavqgvrq rkgdvdglvr
     5701 qwqdfttsve nlfrfltdts hllsavkgqe rfslyqtrsl ihelknkeih fqrrrttcal
     5761 tleageklll ttdlktkesv grrisqlqds wkdmepqlae mikqfqstve twdqcekkik
     5821 elksrlqvlk aqsedplpel hedlhnekel ikeleqslas wtqnlkelqt mkadltrhvl
     5881 vedvmvlkeq iehlhrqwed lclrvairkq eiedrlntwv vfneknkelc awlvqmenkv
     5941 lqtadisiee mieklqkdcm eeinlfsenk lqlkqmgdql ikasnksraa eiddklnkin
     6001 drwqhlfdvi gsrvkklket fafiqqldkn msnlrtwlar ieselskpvv ydvcddqeiq
     6061 krlaeqqdlq rdieqhsagv esvfnicdvl lhdsdacane tecdsiqqtt rsldrrwrni
     6121 camsmerrmk ieetwrlwqk flddysrfed wlksaertaa cpnssevlyt sakeelkrfe
     6181 afqrqiherl tqlelinkqy rrlarenrtd tasrlkqmvh egnqrwdnlq rrvtavlrrl
     6241 rhftnqreef egtresilvw ltemdlqltn vehfsesdad dkmrqlngfq qeitlntnki
     6301 dqlivfgeql iqksepldav liedeleelh rycqevfgrv srfhrrltsc tpgledekea
     6361 senetdmedp reiqtdswrk rgeseepssp qslchlvapg hersgcetpv svdsiplewd
     6421 htgdvggsss heedeegpyy salsgksisd ghswhvpdsp scpehhykqm egdrnvppvp
     6481 passtpykpp ygklllppgt dggkegprvl ngnpqqedgg lagiteqqsg tacnwqssre
     6541 aeygafdrwe miqaqelhnk lkikqnlqql nsdisaittw lkkteaelem lkmakppsdi
     6601 qeielrvkrl qeilkafdty kalvvsvnvs skeflqtesp estelqsrlr qlsllweaaq
     6661 gavdswrggl rqslmqcqgs ktrprsdvlf fkdfhqlsqn lllwlasakn rrqkahvtdp
     6721 kadprallec rrelmqleke lverqpqvdm lqeisnslli kghgedciea eekvhviekk
     6781 lkqlreqvsq dlmalqgtqn pasplpsfde vdsgdqppat svpaprakqf ravrttegee
     6841 etesrvpgst rpqrsflsrv vraalplqll lllllllacl lpsseedysc tqannfarsf
     6901 ypmlrytngp ppt
//
LOCUS       XP_047287109            6912 aa            linear   PRI 05-AUG-2025
DEFINITION  nesprin-2 isoform X8 [Homo sapiens].
ACCESSION   XP_047287109
VERSION     XP_047287109.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431153.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..6912
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..6912
                     /product="nesprin-2 isoform X8"
                     /calculated_mol_wt=799391
     Region          28..138
                     /region_name="CH_SYNE2_rpt1"
                     /note="first calponin homology (CH) domain found in
                     synaptic nuclear envelope protein 2; cd21242"
                     /db_xref="CDD:409091"
     Site            order(33,37,89,91..92,95..96,98,107..115,120,122..123,
                     125..126,129..130,133)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409091"
     Region          178..286
                     /region_name="CH_SYNE2_rpt2"
                     /note="second calponin homology (CH) domain found in
                     synaptic nuclear envelope protein 2 (SYNE-2) and similar
                     proteins; cd21244"
                     /db_xref="CDD:409093"
     Site            order(183,187,237,239..240,243..244,246,255..263,270,
                     272..273,275..276,279..280,283)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409093"
     Region          <1418..2014
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          <1868..>2369
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          <2338..2712
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          2805..>3389
                     /region_name="CCDC158"
                     /note="Coiled-coil domain-containing protein 158;
                     pfam15921"
                     /db_xref="CDD:464943"
     Region          <3656..>3950
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <3811..4113
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <4496..5321
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          4945..5169
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            5054..5059
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5063..5276
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Region          5123..>5875
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Site            5168..5173
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5178..5384
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cl02488"
                     /db_xref="CDD:413338"
     Site            5275..5280
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5919..6133
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6020..6025
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          6137..6350
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6243..6248
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          6567..6790
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6673..6678
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          <6881..6912
                     /region_name="KASH"
                     /note="Nuclear envelope localization domain; pfam10541"
                     /db_xref="CDD:463142"
     CDS             1..6912
                     /gene="SYNE2"
                     /gene_synonym="EDMD5; KASH2; Nesp2; Nesprin-2; NUA;
                     NUANCE; SYNE-2; TROPH"
                     /coded_by="XM_047431153.1:192..20930"
                     /db_xref="GeneID:23224"
                     /db_xref="HGNC:HGNC:17084"
                     /db_xref="MIM:608442"
ORIGIN      
        1 masspelpte deqgswgidd lhislqaeqe dtqkkaftcw insqlarhts psvisdlftd
       61 ikkghvlldl levlsgqqlp rdkgsntfqc riniehaltf lrnrsiklin ihvtdiidgn
      121 psiilgliwt iilhfhiekl aqtlscnynq pslddvsvvd sspassppak kcskvqarwq
      181 msarkalllw aqeqcatyes vnvtdfkssw rngmaflaii halrpdlidm ksvkhrsnkd
      241 nlreafriae qelkiprlle pedvdvvdpd eksimtyvaq flqyskdapg tgeeaqgkvk
      301 damgwltlqk eklqkllkds endtyfkkyn sllsfmesfn eekksfldvl sikrdldeld
      361 kdhlqlreaw dgldhqinaw kiklnyalpp plhqteawlq eveelmdedl sasqdhsqav
      421 tliqekmtlf kslmdrfehh snilltfenk denhlplvpp nkleemkrri nnilekkfil
      481 llefhyykcl vlglvdevks kldiwnikyg sresvellle dwhkfieeke flarldtsfq
      541 kcgeiyknla gecqninkqy mmvksdvcmy rkniynvkst lqkvlacwat yvenlrllra
      601 cfeetkkeei kevpfetlaq wnlehatlne agnflvevsn dvvgssiske lrrlnkrwrk
      661 lvsktqlemn lplmikkqdq ptfdnsgnil skeekatvef stdmsvelpe nynqnikage
      721 khekeneeft gqlkvakdve kligqveiwe aeaksvldqd dvdtsmeesl khliakgsmf
      781 delmarsedm lqmdiqniss qesfqhvltt glqakiqeak ekvqinvvkl iaalknltdv
      841 spdldirlkm eesqkelesy mmraqqllgq respgelisk hkealiisnt kslakylkav
      901 eelknnvted ikmsleeksr dvcakweslh helslyvqql kidiekgkls dnilklekqi
      961 nkekklirrg rtkglikehe acfseegcly qlnhhmevlr elceelpsqk sqqevkrllk
     1021 dyeqkierll kcaseihmtl qptaggtskn egtittsenr ggdphseapf aksdnqpste
     1081 kameptmkfs lasvlrplqe esimekdysa sinslleryd tyrdilehhl qnnkfritsd
     1141 fsseedrsss clqakltdlq viknetdarw kefeiislkl enhvndikkp fvikerdtlk
     1201 ererelqmtl ntrmesleta lrlvlpveka slllcgsdlp lhkmaiqgfh lidadriyqh
     1261 lrniqdsiak qieicnrlee pgnfvlkelh pfdlhamqni ilkyktqfeg mnhrvqrsed
     1321 tlkaledfla slrtaklsae pvtdlsasdt qvaqentltv knkegeihlm kdkakhldkc
     1381 lkmldmsfkd aergddtsce nlldafsikl sethgygvqe efteenklle acifknnell
     1441 kniqdvqsqi skiglkdptv pavkhrkksl irldkvldey eeekrhlqem anslphfkdg
     1501 rektvnqqcq ntvvlwentk alvtecleqc grvlellkqy qnfksilttl iqkeesvisl
     1561 qasymgkenl kkriaeieiv keefnehlev vdkinqvckn lqfylnkmkt feeppfekea
     1621 niivdrwldi nektedyyen lgralalwdk lfnlknvide wtekalqkme lhqlteedre
     1681 rlkeelqvhe qktsefsrrv aeiqfllqss eiplelqvme ssilnkmehv qkcltgesnc
     1741 halsgstael redldqaktq igmtesllka lspsdsleif tkleeiqqqi lqqkhsmill
     1801 enqigcltpe lselkkqyes vsdlfntkks vlqdhfskll ndqcknfndw fsnikvnlke
     1861 cfessetkks veqklqklsd fltlegrnsk ikqvdsvlkh vkkhlpkahv keliswlvgq
     1921 efelekmesi cqarakeled slqqllrlqd dhrnlrkwlt nqeekwkgme epgektelfc
     1981 qalarkreqf esvaqlnnsl keygfteeee iimeatclmd ryqtllrqls eieeedkllp
     2041 tedqsfndla hdvihwikei keslmvlnss egkmpleeri qkikeiillk pegdarieti
     2101 mkqaesseap lvqktltdis nqwdntlhla stylshqekl llegekylqs kedlrlmlie
     2161 lkkkqeagfa lqhglqekka qlkiykkflk kaqdltsllk elksqgnyll ectknpsfse
     2221 epwleikhlh esllqqlqds vqnldghvre hdsyqvcvtd lnttldnfsk efvsfsdkpv
     2281 dqiaveeklq klqelenrls lqdgtlkkil alaksvkqnt ssvgqkiikd dikslqckqk
     2341 dlenrlasak qemecclnsi lkskrstekk gkftlpgrek qatsdvqest qesaavekle
     2401 edweinkdsa vemamskqls lnaqesmknt ederkvnelq nqpleldtml rneqleeiek
     2461 lytqleakka aikpleqtec lnktetgalv lhnigysaqh ldnllqalit lkknkesqyc
     2521 vlrdfqeyla avessmkall tdkeslkvgp ldsvtyldki kkfiasieke kdslgnlkik
     2581 wenlsnhvtd mdkkllesqi kqlehgweqv eqqiqkkysq qvveydeftt lmnkvqdtei
     2641 slqqqqqhlq lrlkspeera gnqsmialtt dlqatkhgfs vlkgqaelqm kriwgekekk
     2701 nledginnlk kqwetleplh leaenqikkc dirnkmketi lwaknllgel npsipllpdd
     2761 ilsqirkckv thdgilarqq sveslaeevk dkvpslttye gsdlnntled lrnqyqmlvl
     2821 kstqrsqqle fkleersnff aiirkfqlmv qesetliipr vetaateael khhhvtleas
     2881 qkelqeidsg isthlqeltn iyeelnvfer lfledqlknl kirtnriqrf iqntcneveh
     2941 kikfcrqfhe ktsalqeead siqrnellln qevnkgvkee iynlkdrlta ikccilqvlk
     3001 lkkvfdyigl nwdfsqldql qtqvfekeke leekikqldt feeehgkyqa llskmraidl
     3061 qikkmtevvl kapdsspesr rlnaqilsqr iekakclcde iikklnenkt fddsfkekei
     3121 lqiklnaeen dklykvlqnm vlelspkeld ekncqdklet slhvlnqiks qlqqpllinl
     3181 eikhiqnekd nceafqeqvw aemcsikavt aiekqreens seasdvetkl refedlqmql
     3241 ntsidlrtnv lndayenltr ykeavtrave sitsleaiii pyrvdvgnpe eslemplrkq
     3301 eelestvahi qdlteklgmi sspeaklqlq ytlqelvskn samkeafkaq eteaerylen
     3361 ykcyrkmeed iytnlskmet vlgqsmsslp lsyrealerl eqskalvsnl istkeelmkl
     3421 rqilrllrlr ctendgicll kivsalwekw lslleaakew emwceelkqe wkfvseeier
     3481 eaiildnlqe elpeisktke aatteelsel ldclcqygen vekqqllltl llqrirsiqn
     3541 vpessgavet vpafqeitsm kercnkllqk vqknkelvqt eiqerhsftk eiialknffq
     3601 qtttsfqnma fqdhpekseq feelqsilkk gkltfenime klrikysemy tivpaeiesq
     3661 veecrkaled idekisnevl ksspsyamrr kieeinnglh nvekmlqqks kniekaqeiq
     3721 kkmwdeldlw hsklneldse vqdiveqdpg qaqewmdnlm ipfqqyqqvs qraecrtsql
     3781 nkatvkmeey sdllksteaw ientshllan padydslrtl shhastvqma ledseqkhnl
     3841 lhsifmdled lsiifetdel tqsiqelsnq vtalqqkime slpqiqrmad dvvaiesevk
     3901 smekrvskik tillskeifd fspeehlkhg evilenirpm kktiaeivsy qvelrlpqtg
     3961 mkplpvfqrt nqllqdikll envtqeqnel lkvvikqtne wdeeienlkq ilnnysaqfs
     4021 lehmspdqad klpqlqgeie rmekqilsln qrkedllvdl katvlnlhqh lkqeqegver
     4081 drlpavtsee ggvaerdase rklnrrgsms ylaaveeeve essvksdngd ekaepspqsw
     4141 sslwkhdkdm eedrassssg tivqeaygki stsdnsmaqi ltpdslnteq gpecslrpnq
     4201 teegttppie adtldssdaq ggleprvekt rpeptevlha cktqvaelel wlqqanvave
     4261 petlnadmqq vleqqlvgcq amlteiehkv aflletckdq glgdngatqh eaealslklk
     4321 tvkcnlekvq mmlqekhsed qhptilkkss epehqealqp vnlselesiv terpqfsrqk
     4381 dfqqqqvlel kpmeqkdfik fiefnakkmw pqycqhdndt tqessasnqa sspendvpds
     4441 ilspqgqngd kwqylhhels skiklplpql vepqvstnmg ilpsvtmynf ryptteelkt
     4501 yttqledlrq easnlqtqen mteeayinld kklfelfltl sqclssveem lemprlyred
     4561 gsgqqvhyet lalelkklyl alsdkkgdll kamtwpgent nlllecfdnl qvclehtqaa
     4621 avcrskslka gldynrsyqn eikrlyhqli ksktslqqsl neisgqsvae qlqkadaytv
     4681 elenaesrva klrdegerlh lpyallqevy kledvldsmw gmlrarytel sspfvtesqq
     4741 dallqgmvel vkigkeklah ghlkqtkskv alqaqienhk vffqklvadm lliqaysaki
     4801 lpsllqnret fwaeqvtevk ileeksrqcg mklqsllqkw eefdenyasl ekdleilist
     4861 lpsvslveet eerlverisf yqqikrnigg kharlyqtln egkqlvasvs cpelegqiak
     4921 leeqwlslnk kidhelhrlq allkhllsyn rdsdqltkwl essqhtlnyw keqslnvsqd
     4981 ldtirsninn ffefskevde ksslktavis ignqllhlke tdtatlrasl aqfeqkwtml
     5041 itqlpdiqek lhqlqmeklp srkaitemis wmnnvehqts dedsvhspss asqvkhllqk
     5101 hkefrmemdy kqwivdfvnq sllqlstcdv eskryertef aehlgemnrq whrvhgmlnr
     5161 kiqhleqlle sitesenkiq ilnnwleaqe erlktlqkpe svisvqklll dcqdienqla
     5221 ikskaldelk qsyltlesga vplledtasr idelfqkrss vltqvnqlkt smqsvlqewk
     5281 iydqlydevn mmtirfwycm ehskpvvlsl etlrcqvenl qslqdeaess egsweklqev
     5341 igklkglcps vaeiieekcq nthkrwtqvn qaiadqlqka qsllqlwkay snahgeaaar
     5401 lkqqeakfqq lanismsgnn laeilppalq dikelqhdvq ktkeaflqns svldrlpqpa
     5461 essthmllpg plhslqraay lekmllvkan efefvlsqfk dfgvrleslk glimheeenl
     5521 drlhqqeken pdsflnhvla ltaqspdieh lnevslklpl sdvavktlqn mnrqwirata
     5581 talercselq giglnekfly ccekwiqlle kieealkvdv anslpelleq qktykmleae
     5641 vsinqtiads yvtqslqlld tteienrpef itefskltdr wqnavqgvrq rkgdvdglvr
     5701 qwqdfttsve nlfrfltdts hllsavkgqe rfslyqtrsl ihelknkeih fqrrrttcal
     5761 tleageklll ttdlktkesv grrisqlqds wkdmepqlae mikqfqstve twdqcekkik
     5821 elksrlqvlk aqsedplpel hedlhnekel ikeleqslas wtqnlkelqt mkadltrhvl
     5881 vedvmvlkeq iehlhrqwed lclrvairkq eiedrlntwv vfneknkelc awlvqmenkv
     5941 lqtadisiee mieklqkdcm eeinlfsenk lqlkqmgdql ikasnksraa eiddklnkin
     6001 drwqhlfdvi gsrvkklket fafiqqldkn msnlrtwlar ieselskpvv ydvcddqeiq
     6061 krlaeqqdlq rdieqhsagv esvfnicdvl lhdsdacane tecdsiqqtt rsldrrwrni
     6121 camsmerrmk ieetwrlwqk flddysrfed wlksaertaa cpnssevlyt sakeelkrfe
     6181 afqrqiherl tqlelinkqy rrlarenrtd tasrlkqmvh egnqrwdnlq rrvtavlrrl
     6241 rhftnqreef egtresilvw ltemdlqltn vehfsesdad dkmrqlngfq qeitlntnki
     6301 dqlivfgeql iqksepldav liedeleelh rycqevfgrv srfhrrltsc tpgledekea
     6361 senetdmedp reiqtdswrk rgeseepssp qslchlvapg hersgcetpv svdsiplewd
     6421 htgdvggsss heedeegpyy salsgksisd ghswhvpdsp scpehhykqm egdrnvppvp
     6481 passtpykpp ygklllppgt dggkegprvl ngnpqqedgg lagiteqqsg tacnwqssre
     6541 aeygafdrwe miqaqelhnk lkikqnlqql nsdisaittw lkkteaelem lkmakppsdi
     6601 qeielrvkrl qeilkafdty kalvvsvnvs skeflqtesp estelqsrlr qlsllweaaq
     6661 gavdswrggl rqslmqcqgs ktrprsdvlf fkdfhqlsqn lllwlasakn rrqkahvtdp
     6721 kadprallec rrelmqleke lverqpqvdm lqeisnslli kghgedciea eekvhviekk
     6781 lkqlreqvsq dlmalqgtqn pasplpsfde vdsgdqppat svpaprakfr avrttegeee
     6841 tesrvpgstr pqrsflsrvv raalplqlll llllllacll psseedysct qannfarsfy
     6901 pmlrytngpp pt
//
LOCUS       XP_005267514            6908 aa            linear   PRI 05-AUG-2025
DEFINITION  nesprin-2 isoform X9 [Homo sapiens].
ACCESSION   XP_005267514
VERSION     XP_005267514.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267457.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..6908
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..6908
                     /product="nesprin-2 isoform X9"
                     /calculated_mol_wt=798863
     Region          28..138
                     /region_name="CH_SYNE2_rpt1"
                     /note="first calponin homology (CH) domain found in
                     synaptic nuclear envelope protein 2; cd21242"
                     /db_xref="CDD:409091"
     Site            order(33,37,89,91..92,95..96,98,107..115,120,122..123,
                     125..126,129..130,133)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409091"
     Region          178..286
                     /region_name="CH_SYNE2_rpt2"
                     /note="second calponin homology (CH) domain found in
                     synaptic nuclear envelope protein 2 (SYNE-2) and similar
                     proteins; cd21244"
                     /db_xref="CDD:409093"
     Site            order(183,187,237,239..240,243..244,246,255..263,270,
                     272..273,275..276,279..280,283)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409093"
     Region          <1418..2014
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          <1868..2417
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          <2338..2712
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          2805..>3389
                     /region_name="CCDC158"
                     /note="Coiled-coil domain-containing protein 158;
                     pfam15921"
                     /db_xref="CDD:464943"
     Region          <3656..>3950
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <3811..4113
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <4496..5321
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          4945..5169
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            5054..5059
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5063..5276
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Region          5123..>5875
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Site            5168..5173
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5178..5384
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cl02488"
                     /db_xref="CDD:413338"
     Site            5275..5280
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5919..6133
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6020..6025
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          6137..6350
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6243..6248
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          6576..6785
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6682..6687
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          <6877..6908
                     /region_name="KASH"
                     /note="Nuclear envelope localization domain; pfam10541"
                     /db_xref="CDD:463142"
     CDS             1..6908
                     /gene="SYNE2"
                     /gene_synonym="EDMD5; KASH2; Nesp2; Nesprin-2; NUA;
                     NUANCE; SYNE-2; TROPH"
                     /coded_by="XM_005267457.2:192..20918"
                     /db_xref="GeneID:23224"
                     /db_xref="HGNC:HGNC:17084"
                     /db_xref="MIM:608442"
ORIGIN      
        1 masspelpte deqgswgidd lhislqaeqe dtqkkaftcw insqlarhts psvisdlftd
       61 ikkghvlldl levlsgqqlp rdkgsntfqc riniehaltf lrnrsiklin ihvtdiidgn
      121 psiilgliwt iilhfhiekl aqtlscnynq pslddvsvvd sspassppak kcskvqarwq
      181 msarkalllw aqeqcatyes vnvtdfkssw rngmaflaii halrpdlidm ksvkhrsnkd
      241 nlreafriae qelkiprlle pedvdvvdpd eksimtyvaq flqyskdapg tgeeaqgkvk
      301 damgwltlqk eklqkllkds endtyfkkyn sllsfmesfn eekksfldvl sikrdldeld
      361 kdhlqlreaw dgldhqinaw kiklnyalpp plhqteawlq eveelmdedl sasqdhsqav
      421 tliqekmtlf kslmdrfehh snilltfenk denhlplvpp nkleemkrri nnilekkfil
      481 llefhyykcl vlglvdevks kldiwnikyg sresvellle dwhkfieeke flarldtsfq
      541 kcgeiyknla gecqninkqy mmvksdvcmy rkniynvkst lqkvlacwat yvenlrllra
      601 cfeetkkeei kevpfetlaq wnlehatlne agnflvevsn dvvgssiske lrrlnkrwrk
      661 lvsktqlemn lplmikkqdq ptfdnsgnil skeekatvef stdmsvelpe nynqnikage
      721 khekeneeft gqlkvakdve kligqveiwe aeaksvldqd dvdtsmeesl khliakgsmf
      781 delmarsedm lqmdiqniss qesfqhvltt glqakiqeak ekvqinvvkl iaalknltdv
      841 spdldirlkm eesqkelesy mmraqqllgq respgelisk hkealiisnt kslakylkav
      901 eelknnvted ikmsleeksr dvcakweslh helslyvqql kidiekgkls dnilklekqi
      961 nkekklirrg rtkglikehe acfseegcly qlnhhmevlr elceelpsqk sqqevkrllk
     1021 dyeqkierll kcaseihmtl qptaggtskn egtittsenr ggdphseapf aksdnqpste
     1081 kameptmkfs lasvlrplqe esimekdysa sinslleryd tyrdilehhl qnnkfritsd
     1141 fsseedrsss clqakltdlq viknetdarw kefeiislkl enhvndikkp fvikerdtlk
     1201 ererelqmtl ntrmesleta lrlvlpveka slllcgsdlp lhkmaiqgfh lidadriyqh
     1261 lrniqdsiak qieicnrlee pgnfvlkelh pfdlhamqni ilkyktqfeg mnhrvqrsed
     1321 tlkaledfla slrtaklsae pvtdlsasdt qvaqentltv knkegeihlm kdkakhldkc
     1381 lkmldmsfkd aergddtsce nlldafsikl sethgygvqe efteenklle acifknnell
     1441 kniqdvqsqi skiglkdptv pavkhrkksl irldkvldey eeekrhlqem anslphfkdg
     1501 rektvnqqcq ntvvlwentk alvtecleqc grvlellkqy qnfksilttl iqkeesvisl
     1561 qasymgkenl kkriaeieiv keefnehlev vdkinqvckn lqfylnkmkt feeppfekea
     1621 niivdrwldi nektedyyen lgralalwdk lfnlknvide wtekalqkme lhqlteedre
     1681 rlkeelqvhe qktsefsrrv aeiqfllqss eiplelqvme ssilnkmehv qkcltgesnc
     1741 halsgstael redldqaktq igmtesllka lspsdsleif tkleeiqqqi lqqkhsmill
     1801 enqigcltpe lselkkqyes vsdlfntkks vlqdhfskll ndqcknfndw fsnikvnlke
     1861 cfessetkks veqklqklsd fltlegrnsk ikqvdsvlkh vkkhlpkahv keliswlvgq
     1921 efelekmesi cqarakeled slqqllrlqd dhrnlrkwlt nqeekwkgme epgektelfc
     1981 qalarkreqf esvaqlnnsl keygfteeee iimeatclmd ryqtllrqls eieeedkllp
     2041 tedqsfndla hdvihwikei keslmvlnss egkmpleeri qkikeiillk pegdarieti
     2101 mkqaesseap lvqktltdis nqwdntlhla stylshqekl llegekylqs kedlrlmlie
     2161 lkkkqeagfa lqhglqekka qlkiykkflk kaqdltsllk elksqgnyll ectknpsfse
     2221 epwleikhlh esllqqlqds vqnldghvre hdsyqvcvtd lnttldnfsk efvsfsdkpv
     2281 dqiaveeklq klqelenrls lqdgtlkkil alaksvkqnt ssvgqkiikd dikslqckqk
     2341 dlenrlasak qemecclnsi lkskrstekk gkftlpgrek qatsdvqest qesaavekle
     2401 edweinkdsa vemamskqls lnaqesmknt ederkvnelq nqpleldtml rneqleeiek
     2461 lytqleakka aikpleqtec lnktetgalv lhnigysaqh ldnllqalit lkknkesqyc
     2521 vlrdfqeyla avessmkall tdkeslkvgp ldsvtyldki kkfiasieke kdslgnlkik
     2581 wenlsnhvtd mdkkllesqi kqlehgweqv eqqiqkkysq qvveydeftt lmnkvqdtei
     2641 slqqqqqhlq lrlkspeera gnqsmialtt dlqatkhgfs vlkgqaelqm kriwgekekk
     2701 nledginnlk kqwetleplh leaenqikkc dirnkmketi lwaknllgel npsipllpdd
     2761 ilsqirkckv thdgilarqq sveslaeevk dkvpslttye gsdlnntled lrnqyqmlvl
     2821 kstqrsqqle fkleersnff aiirkfqlmv qesetliipr vetaateael khhhvtleas
     2881 qkelqeidsg isthlqeltn iyeelnvfer lfledqlknl kirtnriqrf iqntcneveh
     2941 kikfcrqfhe ktsalqeead siqrnellln qevnkgvkee iynlkdrlta ikccilqvlk
     3001 lkkvfdyigl nwdfsqldql qtqvfekeke leekikqldt feeehgkyqa llskmraidl
     3061 qikkmtevvl kapdsspesr rlnaqilsqr iekakclcde iikklnenkt fddsfkekei
     3121 lqiklnaeen dklykvlqnm vlelspkeld ekncqdklet slhvlnqiks qlqqpllinl
     3181 eikhiqnekd nceafqeqvw aemcsikavt aiekqreens seasdvetkl refedlqmql
     3241 ntsidlrtnv lndayenltr ykeavtrave sitsleaiii pyrvdvgnpe eslemplrkq
     3301 eelestvahi qdlteklgmi sspeaklqlq ytlqelvskn samkeafkaq eteaerylen
     3361 ykcyrkmeed iytnlskmet vlgqsmsslp lsyrealerl eqskalvsnl istkeelmkl
     3421 rqilrllrlr ctendgicll kivsalwekw lslleaakew emwceelkqe wkfvseeier
     3481 eaiildnlqe elpeisktke aatteelsel ldclcqygen vekqqllltl llqrirsiqn
     3541 vpessgavet vpafqeitsm kercnkllqk vqknkelvqt eiqerhsftk eiialknffq
     3601 qtttsfqnma fqdhpekseq feelqsilkk gkltfenime klrikysemy tivpaeiesq
     3661 veecrkaled idekisnevl ksspsyamrr kieeinnglh nvekmlqqks kniekaqeiq
     3721 kkmwdeldlw hsklneldse vqdiveqdpg qaqewmdnlm ipfqqyqqvs qraecrtsql
     3781 nkatvkmeey sdllksteaw ientshllan padydslrtl shhastvqma ledseqkhnl
     3841 lhsifmdled lsiifetdel tqsiqelsnq vtalqqkime slpqiqrmad dvvaiesevk
     3901 smekrvskik tillskeifd fspeehlkhg evilenirpm kktiaeivsy qvelrlpqtg
     3961 mkplpvfqrt nqllqdikll envtqeqnel lkvvikqtne wdeeienlkq ilnnysaqfs
     4021 lehmspdqad klpqlqgeie rmekqilsln qrkedllvdl katvlnlhqh lkqeqegver
     4081 drlpavtsee ggvaerdase rklnrrgsms ylaaveeeve essvksdngd ekaepspqsw
     4141 sslwkhdkdm eedrassssg tivqeaygki stsdnsmaqi ltpdslnteq gpecslrpnq
     4201 teegttppie adtldssdaq ggleprvekt rpeptevlha cktqvaelel wlqqanvave
     4261 petlnadmqq vleqqlvgcq amlteiehkv aflletckdq glgdngatqh eaealslklk
     4321 tvkcnlekvq mmlqekhsed qhptilkkss epehqealqp vnlselesiv terpqfsrqk
     4381 dfqqqqvlel kpmeqkdfik fiefnakkmw pqycqhdndt tqessasnqa sspendvpds
     4441 ilspqgqngd kwqylhhels skiklplpql vepqvstnmg ilpsvtmynf ryptteelkt
     4501 yttqledlrq easnlqtqen mteeayinld kklfelfltl sqclssveem lemprlyred
     4561 gsgqqvhyet lalelkklyl alsdkkgdll kamtwpgent nlllecfdnl qvclehtqaa
     4621 avcrskslka gldynrsyqn eikrlyhqli ksktslqqsl neisgqsvae qlqkadaytv
     4681 elenaesrva klrdegerlh lpyallqevy kledvldsmw gmlrarytel sspfvtesqq
     4741 dallqgmvel vkigkeklah ghlkqtkskv alqaqienhk vffqklvadm lliqaysaki
     4801 lpsllqnret fwaeqvtevk ileeksrqcg mklqsllqkw eefdenyasl ekdleilist
     4861 lpsvslveet eerlverisf yqqikrnigg kharlyqtln egkqlvasvs cpelegqiak
     4921 leeqwlslnk kidhelhrlq allkhllsyn rdsdqltkwl essqhtlnyw keqslnvsqd
     4981 ldtirsninn ffefskevde ksslktavis ignqllhlke tdtatlrasl aqfeqkwtml
     5041 itqlpdiqek lhqlqmeklp srkaitemis wmnnvehqts dedsvhspss asqvkhllqk
     5101 hkefrmemdy kqwivdfvnq sllqlstcdv eskryertef aehlgemnrq whrvhgmlnr
     5161 kiqhleqlle sitesenkiq ilnnwleaqe erlktlqkpe svisvqklll dcqdienqla
     5221 ikskaldelk qsyltlesga vplledtasr idelfqkrss vltqvnqlkt smqsvlqewk
     5281 iydqlydevn mmtirfwycm ehskpvvlsl etlrcqvenl qslqdeaess egsweklqev
     5341 igklkglcps vaeiieekcq nthkrwtqvn qaiadqlqka qsllqlwkay snahgeaaar
     5401 lkqqeakfqq lanismsgnn laeilppalq dikelqhdvq ktkeaflqns svldrlpqpa
     5461 essthmllpg plhslqraay lekmllvkan efefvlsqfk dfgvrleslk glimheeenl
     5521 drlhqqeken pdsflnhvla ltaqspdieh lnevslklpl sdvavktlqn mnrqwirata
     5581 talercselq giglnekfly ccekwiqlle kieealkvdv anslpelleq qktykmleae
     5641 vsinqtiads yvtqslqlld tteienrpef itefskltdr wqnavqgvrq rkgdvdglvr
     5701 qwqdfttsve nlfrfltdts hllsavkgqe rfslyqtrsl ihelknkeih fqrrrttcal
     5761 tleageklll ttdlktkesv grrisqlqds wkdmepqlae mikqfqstve twdqcekkik
     5821 elksrlqvlk aqsedplpel hedlhnekel ikeleqslas wtqnlkelqt mkadltrhvl
     5881 vedvmvlkeq iehlhrqwed lclrvairkq eiedrlntwv vfneknkelc awlvqmenkv
     5941 lqtadisiee mieklqkdcm eeinlfsenk lqlkqmgdql ikasnksraa eiddklnkin
     6001 drwqhlfdvi gsrvkklket fafiqqldkn msnlrtwlar ieselskpvv ydvcddqeiq
     6061 krlaeqqdlq rdieqhsagv esvfnicdvl lhdsdacane tecdsiqqtt rsldrrwrni
     6121 camsmerrmk ieetwrlwqk flddysrfed wlksaertaa cpnssevlyt sakeelkrfe
     6181 afqrqiherl tqlelinkqy rrlarenrtd tasrlkqmvh egnqrwdnlq rrvtavlrrl
     6241 rhftnqreef egtresilvw ltemdlqltn vehfsesdad dkmrqlngfq qeitlntnki
     6301 dqlivfgeql iqksepldav liedeleelh rycqevfgrv srfhrrltsc tpgledekea
     6361 senetdmedp reiqtdswrk rgeseepssp qslchlvapg hersgcetpv svdsiplewd
     6421 htgdvggsss heedeegpyy salsdveipe npeaylkmtt ktlkassgks isdghswhvp
     6481 dspscpehhy kqmegdrnvp pvppasstpy kppygklllp pgtdggkegp rvlngnpqqe
     6541 dgglagiteq qsgafdrwem iqaqelhnkl kikqnlqqln sdisaittwl kkteaeleml
     6601 kmakppsdiq eielrvkrlq eilkafdtyk alvvsvnvss keflqtespe stelqsrlrq
     6661 lsllweaaqg avdswrgglr qslmqcqdfh qlsqnlllwl asaknrrqka hvtdpkadpr
     6721 allecrrelm qlekelverq pqvdmlqeis nsllikghge dcieaeekvh viekklkqlr
     6781 eqvsqdlmal qgtqnpaspl psfdevdsgd qppatsvpap rakqfravrt tegeeetesr
     6841 vpgstrpqrs flsrvvraal plqlllllll llacllpsse edysctqann farsfypmlr
     6901 ytngpppt
//
LOCUS       XP_005267515            6899 aa            linear   PRI 05-AUG-2025
DEFINITION  nesprin-2 isoform X10 [Homo sapiens].
ACCESSION   XP_005267515
VERSION     XP_005267515.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267458.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..6899
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..6899
                     /product="nesprin-2 isoform X10"
                     /calculated_mol_wt=797935
     Region          28..138
                     /region_name="CH_SYNE2_rpt1"
                     /note="first calponin homology (CH) domain found in
                     synaptic nuclear envelope protein 2; cd21242"
                     /db_xref="CDD:409091"
     Site            order(33,37,89,91..92,95..96,98,107..115,120,122..123,
                     125..126,129..130,133)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409091"
     Region          178..286
                     /region_name="CH_SYNE2_rpt2"
                     /note="second calponin homology (CH) domain found in
                     synaptic nuclear envelope protein 2 (SYNE-2) and similar
                     proteins; cd21244"
                     /db_xref="CDD:409093"
     Site            order(183,187,237,239..240,243..244,246,255..263,270,
                     272..273,275..276,279..280,283)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409093"
     Region          <1418..2014
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          <1868..>2369
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          <2338..2712
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          2805..>3389
                     /region_name="CCDC158"
                     /note="Coiled-coil domain-containing protein 158;
                     pfam15921"
                     /db_xref="CDD:464943"
     Region          <3656..>3950
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <3811..4113
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <4496..5321
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          4945..5169
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            5054..5059
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5063..5276
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Region          5123..>5875
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Site            5168..5173
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5178..5384
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cl02488"
                     /db_xref="CDD:413338"
     Site            5275..5280
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5919..6133
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6020..6025
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          6137..6350
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6243..6248
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          6553..6776
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6659..6664
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          <6868..6899
                     /region_name="KASH"
                     /note="Nuclear envelope localization domain; pfam10541"
                     /db_xref="CDD:463142"
     CDS             1..6899
                     /gene="SYNE2"
                     /gene_synonym="EDMD5; KASH2; Nesp2; Nesprin-2; NUA;
                     NUANCE; SYNE-2; TROPH"
                     /coded_by="XM_005267458.2:192..20891"
                     /db_xref="GeneID:23224"
                     /db_xref="HGNC:HGNC:17084"
                     /db_xref="MIM:608442"
ORIGIN      
        1 masspelpte deqgswgidd lhislqaeqe dtqkkaftcw insqlarhts psvisdlftd
       61 ikkghvlldl levlsgqqlp rdkgsntfqc riniehaltf lrnrsiklin ihvtdiidgn
      121 psiilgliwt iilhfhiekl aqtlscnynq pslddvsvvd sspassppak kcskvqarwq
      181 msarkalllw aqeqcatyes vnvtdfkssw rngmaflaii halrpdlidm ksvkhrsnkd
      241 nlreafriae qelkiprlle pedvdvvdpd eksimtyvaq flqyskdapg tgeeaqgkvk
      301 damgwltlqk eklqkllkds endtyfkkyn sllsfmesfn eekksfldvl sikrdldeld
      361 kdhlqlreaw dgldhqinaw kiklnyalpp plhqteawlq eveelmdedl sasqdhsqav
      421 tliqekmtlf kslmdrfehh snilltfenk denhlplvpp nkleemkrri nnilekkfil
      481 llefhyykcl vlglvdevks kldiwnikyg sresvellle dwhkfieeke flarldtsfq
      541 kcgeiyknla gecqninkqy mmvksdvcmy rkniynvkst lqkvlacwat yvenlrllra
      601 cfeetkkeei kevpfetlaq wnlehatlne agnflvevsn dvvgssiske lrrlnkrwrk
      661 lvsktqlemn lplmikkqdq ptfdnsgnil skeekatvef stdmsvelpe nynqnikage
      721 khekeneeft gqlkvakdve kligqveiwe aeaksvldqd dvdtsmeesl khliakgsmf
      781 delmarsedm lqmdiqniss qesfqhvltt glqakiqeak ekvqinvvkl iaalknltdv
      841 spdldirlkm eesqkelesy mmraqqllgq respgelisk hkealiisnt kslakylkav
      901 eelknnvted ikmsleeksr dvcakweslh helslyvqql kidiekgkls dnilklekqi
      961 nkekklirrg rtkglikehe acfseegcly qlnhhmevlr elceelpsqk sqqevkrllk
     1021 dyeqkierll kcaseihmtl qptaggtskn egtittsenr ggdphseapf aksdnqpste
     1081 kameptmkfs lasvlrplqe esimekdysa sinslleryd tyrdilehhl qnnkfritsd
     1141 fsseedrsss clqakltdlq viknetdarw kefeiislkl enhvndikkp fvikerdtlk
     1201 ererelqmtl ntrmesleta lrlvlpveka slllcgsdlp lhkmaiqgfh lidadriyqh
     1261 lrniqdsiak qieicnrlee pgnfvlkelh pfdlhamqni ilkyktqfeg mnhrvqrsed
     1321 tlkaledfla slrtaklsae pvtdlsasdt qvaqentltv knkegeihlm kdkakhldkc
     1381 lkmldmsfkd aergddtsce nlldafsikl sethgygvqe efteenklle acifknnell
     1441 kniqdvqsqi skiglkdptv pavkhrkksl irldkvldey eeekrhlqem anslphfkdg
     1501 rektvnqqcq ntvvlwentk alvtecleqc grvlellkqy qnfksilttl iqkeesvisl
     1561 qasymgkenl kkriaeieiv keefnehlev vdkinqvckn lqfylnkmkt feeppfekea
     1621 niivdrwldi nektedyyen lgralalwdk lfnlknvide wtekalqkme lhqlteedre
     1681 rlkeelqvhe qktsefsrrv aeiqfllqss eiplelqvme ssilnkmehv qkcltgesnc
     1741 halsgstael redldqaktq igmtesllka lspsdsleif tkleeiqqqi lqqkhsmill
     1801 enqigcltpe lselkkqyes vsdlfntkks vlqdhfskll ndqcknfndw fsnikvnlke
     1861 cfessetkks veqklqklsd fltlegrnsk ikqvdsvlkh vkkhlpkahv keliswlvgq
     1921 efelekmesi cqarakeled slqqllrlqd dhrnlrkwlt nqeekwkgme epgektelfc
     1981 qalarkreqf esvaqlnnsl keygfteeee iimeatclmd ryqtllrqls eieeedkllp
     2041 tedqsfndla hdvihwikei keslmvlnss egkmpleeri qkikeiillk pegdarieti
     2101 mkqaesseap lvqktltdis nqwdntlhla stylshqekl llegekylqs kedlrlmlie
     2161 lkkkqeagfa lqhglqekka qlkiykkflk kaqdltsllk elksqgnyll ectknpsfse
     2221 epwleikhlh esllqqlqds vqnldghvre hdsyqvcvtd lnttldnfsk efvsfsdkpv
     2281 dqiaveeklq klqelenrls lqdgtlkkil alaksvkqnt ssvgqkiikd dikslqckqk
     2341 dlenrlasak qemecclnsi lkskrstekk gkftlpgrek qatsdvqest qesaavekle
     2401 edweinkdsa vemamskqls lnaqesmknt ederkvnelq nqpleldtml rneqleeiek
     2461 lytqleakka aikpleqtec lnktetgalv lhnigysaqh ldnllqalit lkknkesqyc
     2521 vlrdfqeyla avessmkall tdkeslkvgp ldsvtyldki kkfiasieke kdslgnlkik
     2581 wenlsnhvtd mdkkllesqi kqlehgweqv eqqiqkkysq qvveydeftt lmnkvqdtei
     2641 slqqqqqhlq lrlkspeera gnqsmialtt dlqatkhgfs vlkgqaelqm kriwgekekk
     2701 nledginnlk kqwetleplh leaenqikkc dirnkmketi lwaknllgel npsipllpdd
     2761 ilsqirkckv thdgilarqq sveslaeevk dkvpslttye gsdlnntled lrnqyqmlvl
     2821 kstqrsqqle fkleersnff aiirkfqlmv qesetliipr vetaateael khhhvtleas
     2881 qkelqeidsg isthlqeltn iyeelnvfer lfledqlknl kirtnriqrf iqntcneveh
     2941 kikfcrqfhe ktsalqeead siqrnellln qevnkgvkee iynlkdrlta ikccilqvlk
     3001 lkkvfdyigl nwdfsqldql qtqvfekeke leekikqldt feeehgkyqa llskmraidl
     3061 qikkmtevvl kapdsspesr rlnaqilsqr iekakclcde iikklnenkt fddsfkekei
     3121 lqiklnaeen dklykvlqnm vlelspkeld ekncqdklet slhvlnqiks qlqqpllinl
     3181 eikhiqnekd nceafqeqvw aemcsikavt aiekqreens seasdvetkl refedlqmql
     3241 ntsidlrtnv lndayenltr ykeavtrave sitsleaiii pyrvdvgnpe eslemplrkq
     3301 eelestvahi qdlteklgmi sspeaklqlq ytlqelvskn samkeafkaq eteaerylen
     3361 ykcyrkmeed iytnlskmet vlgqsmsslp lsyrealerl eqskalvsnl istkeelmkl
     3421 rqilrllrlr ctendgicll kivsalwekw lslleaakew emwceelkqe wkfvseeier
     3481 eaiildnlqe elpeisktke aatteelsel ldclcqygen vekqqllltl llqrirsiqn
     3541 vpessgavet vpafqeitsm kercnkllqk vqknkelvqt eiqerhsftk eiialknffq
     3601 qtttsfqnma fqdhpekseq feelqsilkk gkltfenime klrikysemy tivpaeiesq
     3661 veecrkaled idekisnevl ksspsyamrr kieeinnglh nvekmlqqks kniekaqeiq
     3721 kkmwdeldlw hsklneldse vqdiveqdpg qaqewmdnlm ipfqqyqqvs qraecrtsql
     3781 nkatvkmeey sdllksteaw ientshllan padydslrtl shhastvqma ledseqkhnl
     3841 lhsifmdled lsiifetdel tqsiqelsnq vtalqqkime slpqiqrmad dvvaiesevk
     3901 smekrvskik tillskeifd fspeehlkhg evilenirpm kktiaeivsy qvelrlpqtg
     3961 mkplpvfqrt nqllqdikll envtqeqnel lkvvikqtne wdeeienlkq ilnnysaqfs
     4021 lehmspdqad klpqlqgeie rmekqilsln qrkedllvdl katvlnlhqh lkqeqegver
     4081 drlpavtsee ggvaerdase rklnrrgsms ylaaveeeve essvksdngd ekaepspqsw
     4141 sslwkhdkdm eedrassssg tivqeaygki stsdnsmaqi ltpdslnteq gpecslrpnq
     4201 teegttppie adtldssdaq ggleprvekt rpeptevlha cktqvaelel wlqqanvave
     4261 petlnadmqq vleqqlvgcq amlteiehkv aflletckdq glgdngatqh eaealslklk
     4321 tvkcnlekvq mmlqekhsed qhptilkkss epehqealqp vnlselesiv terpqfsrqk
     4381 dfqqqqvlel kpmeqkdfik fiefnakkmw pqycqhdndt tqessasnqa sspendvpds
     4441 ilspqgqngd kwqylhhels skiklplpql vepqvstnmg ilpsvtmynf ryptteelkt
     4501 yttqledlrq easnlqtqen mteeayinld kklfelfltl sqclssveem lemprlyred
     4561 gsgqqvhyet lalelkklyl alsdkkgdll kamtwpgent nlllecfdnl qvclehtqaa
     4621 avcrskslka gldynrsyqn eikrlyhqli ksktslqqsl neisgqsvae qlqkadaytv
     4681 elenaesrva klrdegerlh lpyallqevy kledvldsmw gmlrarytel sspfvtesqq
     4741 dallqgmvel vkigkeklah ghlkqtkskv alqaqienhk vffqklvadm lliqaysaki
     4801 lpsllqnret fwaeqvtevk ileeksrqcg mklqsllqkw eefdenyasl ekdleilist
     4861 lpsvslveet eerlverisf yqqikrnigg kharlyqtln egkqlvasvs cpelegqiak
     4921 leeqwlslnk kidhelhrlq allkhllsyn rdsdqltkwl essqhtlnyw keqslnvsqd
     4981 ldtirsninn ffefskevde ksslktavis ignqllhlke tdtatlrasl aqfeqkwtml
     5041 itqlpdiqek lhqlqmeklp srkaitemis wmnnvehqts dedsvhspss asqvkhllqk
     5101 hkefrmemdy kqwivdfvnq sllqlstcdv eskryertef aehlgemnrq whrvhgmlnr
     5161 kiqhleqlle sitesenkiq ilnnwleaqe erlktlqkpe svisvqklll dcqdienqla
     5221 ikskaldelk qsyltlesga vplledtasr idelfqkrss vltqvnqlkt smqsvlqewk
     5281 iydqlydevn mmtirfwycm ehskpvvlsl etlrcqvenl qslqdeaess egsweklqev
     5341 igklkglcps vaeiieekcq nthkrwtqvn qaiadqlqka qsllqlwkay snahgeaaar
     5401 lkqqeakfqq lanismsgnn laeilppalq dikelqhdvq ktkeaflqns svldrlpqpa
     5461 essthmllpg plhslqraay lekmllvkan efefvlsqfk dfgvrleslk glimheeenl
     5521 drlhqqeken pdsflnhvla ltaqspdieh lnevslklpl sdvavktlqn mnrqwirata
     5581 talercselq giglnekfly ccekwiqlle kieealkvdv anslpelleq qktykmleae
     5641 vsinqtiads yvtqslqlld tteienrpef itefskltdr wqnavqgvrq rkgdvdglvr
     5701 qwqdfttsve nlfrfltdts hllsavkgqe rfslyqtrsl ihelknkeih fqrrrttcal
     5761 tleageklll ttdlktkesv grrisqlqds wkdmepqlae mikqfqstve twdqcekkik
     5821 elksrlqvlk aqsedplpel hedlhnekel ikeleqslas wtqnlkelqt mkadltrhvl
     5881 vedvmvlkeq iehlhrqwed lclrvairkq eiedrlntwv vfneknkelc awlvqmenkv
     5941 lqtadisiee mieklqkdcm eeinlfsenk lqlkqmgdql ikasnksraa eiddklnkin
     6001 drwqhlfdvi gsrvkklket fafiqqldkn msnlrtwlar ieselskpvv ydvcddqeiq
     6061 krlaeqqdlq rdieqhsagv esvfnicdvl lhdsdacane tecdsiqqtt rsldrrwrni
     6121 camsmerrmk ieetwrlwqk flddysrfed wlksaertaa cpnssevlyt sakeelkrfe
     6181 afqrqiherl tqlelinkqy rrlarenrtd tasrlkqmvh egnqrwdnlq rrvtavlrrl
     6241 rhftnqreef egtresilvw ltemdlqltn vehfsesdad dkmrqlngfq qeitlntnki
     6301 dqlivfgeql iqksepldav liedeleelh rycqevfgrv srfhrrltsc tpgledekea
     6361 senetdmedp reiqtdswrk rgeseepssp qslchlvapg hersgcetpv svdsiplewd
     6421 htgdvggsss heedeegpyy salsgksisd ghswhvpdsp scpehhykqm egdrnvppvp
     6481 passtpykpp ygklllppgt dggkegprvl ngnpqqedgg lagiteqqsg afdrwemiqa
     6541 qelhnklkik qnlqqlnsdi saittwlkkt eaelemlkma kppsdiqeie lrvkrlqeil
     6601 kafdtykalv vsvnvsskef lqtespeste lqsrlrqlsl lweaaqgavd swrgglrqsl
     6661 mqcqgsktrp rsdvlffkdf hqlsqnlllw lasaknrrqk ahvtdpkadp rallecrrel
     6721 mqlekelver qpqvdmlqei snsllikghg edcieaeekv hviekklkql reqvsqdlma
     6781 lqgtqnpasp lpsfdevdsg dqppatsvpa prakqfravr ttegeeetes rvpgstrpqr
     6841 sflsrvvraa lplqllllll lllacllpss eedysctqan nfarsfypml rytngpppt
//
LOCUS       XP_047287110            6899 aa            linear   PRI 05-AUG-2025
DEFINITION  nesprin-2 isoform X11 [Homo sapiens].
ACCESSION   XP_047287110
VERSION     XP_047287110.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431154.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..6899
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..6899
                     /product="nesprin-2 isoform X11"
                     /calculated_mol_wt=797899
     Region          28..138
                     /region_name="CH_SYNE2_rpt1"
                     /note="first calponin homology (CH) domain found in
                     synaptic nuclear envelope protein 2; cd21242"
                     /db_xref="CDD:409091"
     Site            order(33,37,89,91..92,95..96,98,107..115,120,122..123,
                     125..126,129..130,133)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409091"
     Region          178..286
                     /region_name="CH_SYNE2_rpt2"
                     /note="second calponin homology (CH) domain found in
                     synaptic nuclear envelope protein 2 (SYNE-2) and similar
                     proteins; cd21244"
                     /db_xref="CDD:409093"
     Site            order(183,187,237,239..240,243..244,246,255..263,270,
                     272..273,275..276,279..280,283)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409093"
     Region          <1418..2014
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          <1868..>2369
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          <2338..2712
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          2805..>3389
                     /region_name="CCDC158"
                     /note="Coiled-coil domain-containing protein 158;
                     pfam15921"
                     /db_xref="CDD:464943"
     Region          <3656..>3950
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <3811..4113
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <4496..5321
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          4945..5169
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            5054..5059
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5063..5276
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Region          5123..>5875
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Site            5168..5173
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5178..5384
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cl02488"
                     /db_xref="CDD:413338"
     Site            5275..5280
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5919..6133
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6020..6025
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          6137..6350
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6243..6248
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          6567..6776
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6673..6678
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          <6868..6899
                     /region_name="KASH"
                     /note="Nuclear envelope localization domain; pfam10541"
                     /db_xref="CDD:463142"
     CDS             1..6899
                     /gene="SYNE2"
                     /gene_synonym="EDMD5; KASH2; Nesp2; Nesprin-2; NUA;
                     NUANCE; SYNE-2; TROPH"
                     /coded_by="XM_047431154.1:192..20891"
                     /db_xref="GeneID:23224"
                     /db_xref="HGNC:HGNC:17084"
                     /db_xref="MIM:608442"
ORIGIN      
        1 masspelpte deqgswgidd lhislqaeqe dtqkkaftcw insqlarhts psvisdlftd
       61 ikkghvlldl levlsgqqlp rdkgsntfqc riniehaltf lrnrsiklin ihvtdiidgn
      121 psiilgliwt iilhfhiekl aqtlscnynq pslddvsvvd sspassppak kcskvqarwq
      181 msarkalllw aqeqcatyes vnvtdfkssw rngmaflaii halrpdlidm ksvkhrsnkd
      241 nlreafriae qelkiprlle pedvdvvdpd eksimtyvaq flqyskdapg tgeeaqgkvk
      301 damgwltlqk eklqkllkds endtyfkkyn sllsfmesfn eekksfldvl sikrdldeld
      361 kdhlqlreaw dgldhqinaw kiklnyalpp plhqteawlq eveelmdedl sasqdhsqav
      421 tliqekmtlf kslmdrfehh snilltfenk denhlplvpp nkleemkrri nnilekkfil
      481 llefhyykcl vlglvdevks kldiwnikyg sresvellle dwhkfieeke flarldtsfq
      541 kcgeiyknla gecqninkqy mmvksdvcmy rkniynvkst lqkvlacwat yvenlrllra
      601 cfeetkkeei kevpfetlaq wnlehatlne agnflvevsn dvvgssiske lrrlnkrwrk
      661 lvsktqlemn lplmikkqdq ptfdnsgnil skeekatvef stdmsvelpe nynqnikage
      721 khekeneeft gqlkvakdve kligqveiwe aeaksvldqd dvdtsmeesl khliakgsmf
      781 delmarsedm lqmdiqniss qesfqhvltt glqakiqeak ekvqinvvkl iaalknltdv
      841 spdldirlkm eesqkelesy mmraqqllgq respgelisk hkealiisnt kslakylkav
      901 eelknnvted ikmsleeksr dvcakweslh helslyvqql kidiekgkls dnilklekqi
      961 nkekklirrg rtkglikehe acfseegcly qlnhhmevlr elceelpsqk sqqevkrllk
     1021 dyeqkierll kcaseihmtl qptaggtskn egtittsenr ggdphseapf aksdnqpste
     1081 kameptmkfs lasvlrplqe esimekdysa sinslleryd tyrdilehhl qnnkfritsd
     1141 fsseedrsss clqakltdlq viknetdarw kefeiislkl enhvndikkp fvikerdtlk
     1201 ererelqmtl ntrmesleta lrlvlpveka slllcgsdlp lhkmaiqgfh lidadriyqh
     1261 lrniqdsiak qieicnrlee pgnfvlkelh pfdlhamqni ilkyktqfeg mnhrvqrsed
     1321 tlkaledfla slrtaklsae pvtdlsasdt qvaqentltv knkegeihlm kdkakhldkc
     1381 lkmldmsfkd aergddtsce nlldafsikl sethgygvqe efteenklle acifknnell
     1441 kniqdvqsqi skiglkdptv pavkhrkksl irldkvldey eeekrhlqem anslphfkdg
     1501 rektvnqqcq ntvvlwentk alvtecleqc grvlellkqy qnfksilttl iqkeesvisl
     1561 qasymgkenl kkriaeieiv keefnehlev vdkinqvckn lqfylnkmkt feeppfekea
     1621 niivdrwldi nektedyyen lgralalwdk lfnlknvide wtekalqkme lhqlteedre
     1681 rlkeelqvhe qktsefsrrv aeiqfllqss eiplelqvme ssilnkmehv qkcltgesnc
     1741 halsgstael redldqaktq igmtesllka lspsdsleif tkleeiqqqi lqqkhsmill
     1801 enqigcltpe lselkkqyes vsdlfntkks vlqdhfskll ndqcknfndw fsnikvnlke
     1861 cfessetkks veqklqklsd fltlegrnsk ikqvdsvlkh vkkhlpkahv keliswlvgq
     1921 efelekmesi cqarakeled slqqllrlqd dhrnlrkwlt nqeekwkgme epgektelfc
     1981 qalarkreqf esvaqlnnsl keygfteeee iimeatclmd ryqtllrqls eieeedkllp
     2041 tedqsfndla hdvihwikei keslmvlnss egkmpleeri qkikeiillk pegdarieti
     2101 mkqaesseap lvqktltdis nqwdntlhla stylshqekl llegekylqs kedlrlmlie
     2161 lkkkqeagfa lqhglqekka qlkiykkflk kaqdltsllk elksqgnyll ectknpsfse
     2221 epwleikhlh esllqqlqds vqnldghvre hdsyqvcvtd lnttldnfsk efvsfsdkpv
     2281 dqiaveeklq klqelenrls lqdgtlkkil alaksvkqnt ssvgqkiikd dikslqckqk
     2341 dlenrlasak qemecclnsi lkskrstekk gkftlpgrek qatsdvqest qesaavekle
     2401 edweinkdsa vemamskqls lnaqesmknt ederkvnelq nqpleldtml rneqleeiek
     2461 lytqleakka aikpleqtec lnktetgalv lhnigysaqh ldnllqalit lkknkesqyc
     2521 vlrdfqeyla avessmkall tdkeslkvgp ldsvtyldki kkfiasieke kdslgnlkik
     2581 wenlsnhvtd mdkkllesqi kqlehgweqv eqqiqkkysq qvveydeftt lmnkvqdtei
     2641 slqqqqqhlq lrlkspeera gnqsmialtt dlqatkhgfs vlkgqaelqm kriwgekekk
     2701 nledginnlk kqwetleplh leaenqikkc dirnkmketi lwaknllgel npsipllpdd
     2761 ilsqirkckv thdgilarqq sveslaeevk dkvpslttye gsdlnntled lrnqyqmlvl
     2821 kstqrsqqle fkleersnff aiirkfqlmv qesetliipr vetaateael khhhvtleas
     2881 qkelqeidsg isthlqeltn iyeelnvfer lfledqlknl kirtnriqrf iqntcneveh
     2941 kikfcrqfhe ktsalqeead siqrnellln qevnkgvkee iynlkdrlta ikccilqvlk
     3001 lkkvfdyigl nwdfsqldql qtqvfekeke leekikqldt feeehgkyqa llskmraidl
     3061 qikkmtevvl kapdsspesr rlnaqilsqr iekakclcde iikklnenkt fddsfkekei
     3121 lqiklnaeen dklykvlqnm vlelspkeld ekncqdklet slhvlnqiks qlqqpllinl
     3181 eikhiqnekd nceafqeqvw aemcsikavt aiekqreens seasdvetkl refedlqmql
     3241 ntsidlrtnv lndayenltr ykeavtrave sitsleaiii pyrvdvgnpe eslemplrkq
     3301 eelestvahi qdlteklgmi sspeaklqlq ytlqelvskn samkeafkaq eteaerylen
     3361 ykcyrkmeed iytnlskmet vlgqsmsslp lsyrealerl eqskalvsnl istkeelmkl
     3421 rqilrllrlr ctendgicll kivsalwekw lslleaakew emwceelkqe wkfvseeier
     3481 eaiildnlqe elpeisktke aatteelsel ldclcqygen vekqqllltl llqrirsiqn
     3541 vpessgavet vpafqeitsm kercnkllqk vqknkelvqt eiqerhsftk eiialknffq
     3601 qtttsfqnma fqdhpekseq feelqsilkk gkltfenime klrikysemy tivpaeiesq
     3661 veecrkaled idekisnevl ksspsyamrr kieeinnglh nvekmlqqks kniekaqeiq
     3721 kkmwdeldlw hsklneldse vqdiveqdpg qaqewmdnlm ipfqqyqqvs qraecrtsql
     3781 nkatvkmeey sdllksteaw ientshllan padydslrtl shhastvqma ledseqkhnl
     3841 lhsifmdled lsiifetdel tqsiqelsnq vtalqqkime slpqiqrmad dvvaiesevk
     3901 smekrvskik tillskeifd fspeehlkhg evilenirpm kktiaeivsy qvelrlpqtg
     3961 mkplpvfqrt nqllqdikll envtqeqnel lkvvikqtne wdeeienlkq ilnnysaqfs
     4021 lehmspdqad klpqlqgeie rmekqilsln qrkedllvdl katvlnlhqh lkqeqegver
     4081 drlpavtsee ggvaerdase rklnrrgsms ylaaveeeve essvksdngd ekaepspqsw
     4141 sslwkhdkdm eedrassssg tivqeaygki stsdnsmaqi ltpdslnteq gpecslrpnq
     4201 teegttppie adtldssdaq ggleprvekt rpeptevlha cktqvaelel wlqqanvave
     4261 petlnadmqq vleqqlvgcq amlteiehkv aflletckdq glgdngatqh eaealslklk
     4321 tvkcnlekvq mmlqekhsed qhptilkkss epehqealqp vnlselesiv terpqfsrqk
     4381 dfqqqqvlel kpmeqkdfik fiefnakkmw pqycqhdndt tqessasnqa sspendvpds
     4441 ilspqgqngd kwqylhhels skiklplpql vepqvstnmg ilpsvtmynf ryptteelkt
     4501 yttqledlrq easnlqtqen mteeayinld kklfelfltl sqclssveem lemprlyred
     4561 gsgqqvhyet lalelkklyl alsdkkgdll kamtwpgent nlllecfdnl qvclehtqaa
     4621 avcrskslka gldynrsyqn eikrlyhqli ksktslqqsl neisgqsvae qlqkadaytv
     4681 elenaesrva klrdegerlh lpyallqevy kledvldsmw gmlrarytel sspfvtesqq
     4741 dallqgmvel vkigkeklah ghlkqtkskv alqaqienhk vffqklvadm lliqaysaki
     4801 lpsllqnret fwaeqvtevk ileeksrqcg mklqsllqkw eefdenyasl ekdleilist
     4861 lpsvslveet eerlverisf yqqikrnigg kharlyqtln egkqlvasvs cpelegqiak
     4921 leeqwlslnk kidhelhrlq allkhllsyn rdsdqltkwl essqhtlnyw keqslnvsqd
     4981 ldtirsninn ffefskevde ksslktavis ignqllhlke tdtatlrasl aqfeqkwtml
     5041 itqlpdiqek lhqlqmeklp srkaitemis wmnnvehqts dedsvhspss asqvkhllqk
     5101 hkefrmemdy kqwivdfvnq sllqlstcdv eskryertef aehlgemnrq whrvhgmlnr
     5161 kiqhleqlle sitesenkiq ilnnwleaqe erlktlqkpe svisvqklll dcqdienqla
     5221 ikskaldelk qsyltlesga vplledtasr idelfqkrss vltqvnqlkt smqsvlqewk
     5281 iydqlydevn mmtirfwycm ehskpvvlsl etlrcqvenl qslqdeaess egsweklqev
     5341 igklkglcps vaeiieekcq nthkrwtqvn qaiadqlqka qsllqlwkay snahgeaaar
     5401 lkqqeakfqq lanismsgnn laeilppalq dikelqhdvq ktkeaflqns svldrlpqpa
     5461 essthmllpg plhslqraay lekmllvkan efefvlsqfk dfgvrleslk glimheeenl
     5521 drlhqqeken pdsflnhvla ltaqspdieh lnevslklpl sdvavktlqn mnrqwirata
     5581 talercselq giglnekfly ccekwiqlle kieealkvdv anslpelleq qktykmleae
     5641 vsinqtiads yvtqslqlld tteienrpef itefskltdr wqnavqgvrq rkgdvdglvr
     5701 qwqdfttsve nlfrfltdts hllsavkgqe rfslyqtrsl ihelknkeih fqrrrttcal
     5761 tleageklll ttdlktkesv grrisqlqds wkdmepqlae mikqfqstve twdqcekkik
     5821 elksrlqvlk aqsedplpel hedlhnekel ikeleqslas wtqnlkelqt mkadltrhvl
     5881 vedvmvlkeq iehlhrqwed lclrvairkq eiedrlntwv vfneknkelc awlvqmenkv
     5941 lqtadisiee mieklqkdcm eeinlfsenk lqlkqmgdql ikasnksraa eiddklnkin
     6001 drwqhlfdvi gsrvkklket fafiqqldkn msnlrtwlar ieselskpvv ydvcddqeiq
     6061 krlaeqqdlq rdieqhsagv esvfnicdvl lhdsdacane tecdsiqqtt rsldrrwrni
     6121 camsmerrmk ieetwrlwqk flddysrfed wlksaertaa cpnssevlyt sakeelkrfe
     6181 afqrqiherl tqlelinkqy rrlarenrtd tasrlkqmvh egnqrwdnlq rrvtavlrrl
     6241 rhftnqreef egtresilvw ltemdlqltn vehfsesdad dkmrqlngfq qeitlntnki
     6301 dqlivfgeql iqksepldav liedeleelh rycqevfgrv srfhrrltsc tpgledekea
     6361 senetdmedp reiqtdswrk rgeseepssp qslchlvapg hersgcetpv svdsiplewd
     6421 htgdvggsss heedeegpyy salsgksisd ghswhvpdsp scpehhykqm egdrnvppvp
     6481 passtpykpp ygklllppgt dggkegprvl ngnpqqedgg lagiteqqsg tacnwqssre
     6541 aeygafdrwe miqaqelhnk lkikqnlqql nsdisaittw lkkteaelem lkmakppsdi
     6601 qeielrvkrl qeilkafdty kalvvsvnvs skeflqtesp estelqsrlr qlsllweaaq
     6661 gavdswrggl rqslmqcqdf hqlsqnlllw lasaknrrqk ahvtdpkadp rallecrrel
     6721 mqlekelver qpqvdmlqei snsllikghg edcieaeekv hviekklkql reqvsqdlma
     6781 lqgtqnpasp lpsfdevdsg dqppatsvpa prakqfravr ttegeeetes rvpgstrpqr
     6841 sflsrvvraa lplqllllll lllacllpss eedysctqan nfarsfypml rytngpppt
//
LOCUS       XP_047287111            6898 aa            linear   PRI 05-AUG-2025
DEFINITION  nesprin-2 isoform X12 [Homo sapiens].
ACCESSION   XP_047287111
VERSION     XP_047287111.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431155.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..6898
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..6898
                     /product="nesprin-2 isoform X12"
                     /calculated_mol_wt=797807
     Region          28..138
                     /region_name="CH_SYNE2_rpt1"
                     /note="first calponin homology (CH) domain found in
                     synaptic nuclear envelope protein 2; cd21242"
                     /db_xref="CDD:409091"
     Site            order(33,37,89,91..92,95..96,98,107..115,120,122..123,
                     125..126,129..130,133)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409091"
     Region          178..286
                     /region_name="CH_SYNE2_rpt2"
                     /note="second calponin homology (CH) domain found in
                     synaptic nuclear envelope protein 2 (SYNE-2) and similar
                     proteins; cd21244"
                     /db_xref="CDD:409093"
     Site            order(183,187,237,239..240,243..244,246,255..263,270,
                     272..273,275..276,279..280,283)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409093"
     Region          <1418..2014
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          <1868..2417
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          <2338..2712
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          2805..>3389
                     /region_name="CCDC158"
                     /note="Coiled-coil domain-containing protein 158;
                     pfam15921"
                     /db_xref="CDD:464943"
     Region          <3656..>3950
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <3811..4113
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <4496..5321
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          4945..5169
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            5054..5059
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5063..5276
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Region          5123..>5875
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Site            5168..5173
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5178..5384
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cl02488"
                     /db_xref="CDD:413338"
     Site            5275..5280
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5919..6133
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6020..6025
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          6137..6350
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6243..6248
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          6553..6776
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6659..6664
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          <6867..6898
                     /region_name="KASH"
                     /note="Nuclear envelope localization domain; pfam10541"
                     /db_xref="CDD:463142"
     CDS             1..6898
                     /gene="SYNE2"
                     /gene_synonym="EDMD5; KASH2; Nesp2; Nesprin-2; NUA;
                     NUANCE; SYNE-2; TROPH"
                     /coded_by="XM_047431155.1:192..20888"
                     /db_xref="GeneID:23224"
                     /db_xref="HGNC:HGNC:17084"
                     /db_xref="MIM:608442"
ORIGIN      
        1 masspelpte deqgswgidd lhislqaeqe dtqkkaftcw insqlarhts psvisdlftd
       61 ikkghvlldl levlsgqqlp rdkgsntfqc riniehaltf lrnrsiklin ihvtdiidgn
      121 psiilgliwt iilhfhiekl aqtlscnynq pslddvsvvd sspassppak kcskvqarwq
      181 msarkalllw aqeqcatyes vnvtdfkssw rngmaflaii halrpdlidm ksvkhrsnkd
      241 nlreafriae qelkiprlle pedvdvvdpd eksimtyvaq flqyskdapg tgeeaqgkvk
      301 damgwltlqk eklqkllkds endtyfkkyn sllsfmesfn eekksfldvl sikrdldeld
      361 kdhlqlreaw dgldhqinaw kiklnyalpp plhqteawlq eveelmdedl sasqdhsqav
      421 tliqekmtlf kslmdrfehh snilltfenk denhlplvpp nkleemkrri nnilekkfil
      481 llefhyykcl vlglvdevks kldiwnikyg sresvellle dwhkfieeke flarldtsfq
      541 kcgeiyknla gecqninkqy mmvksdvcmy rkniynvkst lqkvlacwat yvenlrllra
      601 cfeetkkeei kevpfetlaq wnlehatlne agnflvevsn dvvgssiske lrrlnkrwrk
      661 lvsktqlemn lplmikkqdq ptfdnsgnil skeekatvef stdmsvelpe nynqnikage
      721 khekeneeft gqlkvakdve kligqveiwe aeaksvldqd dvdtsmeesl khliakgsmf
      781 delmarsedm lqmdiqniss qesfqhvltt glqakiqeak ekvqinvvkl iaalknltdv
      841 spdldirlkm eesqkelesy mmraqqllgq respgelisk hkealiisnt kslakylkav
      901 eelknnvted ikmsleeksr dvcakweslh helslyvqql kidiekgkls dnilklekqi
      961 nkekklirrg rtkglikehe acfseegcly qlnhhmevlr elceelpsqk sqqevkrllk
     1021 dyeqkierll kcaseihmtl qptaggtskn egtittsenr ggdphseapf aksdnqpste
     1081 kameptmkfs lasvlrplqe esimekdysa sinslleryd tyrdilehhl qnnkfritsd
     1141 fsseedrsss clqakltdlq viknetdarw kefeiislkl enhvndikkp fvikerdtlk
     1201 ererelqmtl ntrmesleta lrlvlpveka slllcgsdlp lhkmaiqgfh lidadriyqh
     1261 lrniqdsiak qieicnrlee pgnfvlkelh pfdlhamqni ilkyktqfeg mnhrvqrsed
     1321 tlkaledfla slrtaklsae pvtdlsasdt qvaqentltv knkegeihlm kdkakhldkc
     1381 lkmldmsfkd aergddtsce nlldafsikl sethgygvqe efteenklle acifknnell
     1441 kniqdvqsqi skiglkdptv pavkhrkksl irldkvldey eeekrhlqem anslphfkdg
     1501 rektvnqqcq ntvvlwentk alvtecleqc grvlellkqy qnfksilttl iqkeesvisl
     1561 qasymgkenl kkriaeieiv keefnehlev vdkinqvckn lqfylnkmkt feeppfekea
     1621 niivdrwldi nektedyyen lgralalwdk lfnlknvide wtekalqkme lhqlteedre
     1681 rlkeelqvhe qktsefsrrv aeiqfllqss eiplelqvme ssilnkmehv qkcltgesnc
     1741 halsgstael redldqaktq igmtesllka lspsdsleif tkleeiqqqi lqqkhsmill
     1801 enqigcltpe lselkkqyes vsdlfntkks vlqdhfskll ndqcknfndw fsnikvnlke
     1861 cfessetkks veqklqklsd fltlegrnsk ikqvdsvlkh vkkhlpkahv keliswlvgq
     1921 efelekmesi cqarakeled slqqllrlqd dhrnlrkwlt nqeekwkgme epgektelfc
     1981 qalarkreqf esvaqlnnsl keygfteeee iimeatclmd ryqtllrqls eieeedkllp
     2041 tedqsfndla hdvihwikei keslmvlnss egkmpleeri qkikeiillk pegdarieti
     2101 mkqaesseap lvqktltdis nqwdntlhla stylshqekl llegekylqs kedlrlmlie
     2161 lkkkqeagfa lqhglqekka qlkiykkflk kaqdltsllk elksqgnyll ectknpsfse
     2221 epwleikhlh esllqqlqds vqnldghvre hdsyqvcvtd lnttldnfsk efvsfsdkpv
     2281 dqiaveeklq klqelenrls lqdgtlkkil alaksvkqnt ssvgqkiikd dikslqckqk
     2341 dlenrlasak qemecclnsi lkskrstekk gkftlpgrek qatsdvqest qesaavekle
     2401 edweinkdsa vemamskqls lnaqesmknt ederkvnelq nqpleldtml rneqleeiek
     2461 lytqleakka aikpleqtec lnktetgalv lhnigysaqh ldnllqalit lkknkesqyc
     2521 vlrdfqeyla avessmkall tdkeslkvgp ldsvtyldki kkfiasieke kdslgnlkik
     2581 wenlsnhvtd mdkkllesqi kqlehgweqv eqqiqkkysq qvveydeftt lmnkvqdtei
     2641 slqqqqqhlq lrlkspeera gnqsmialtt dlqatkhgfs vlkgqaelqm kriwgekekk
     2701 nledginnlk kqwetleplh leaenqikkc dirnkmketi lwaknllgel npsipllpdd
     2761 ilsqirkckv thdgilarqq sveslaeevk dkvpslttye gsdlnntled lrnqyqmlvl
     2821 kstqrsqqle fkleersnff aiirkfqlmv qesetliipr vetaateael khhhvtleas
     2881 qkelqeidsg isthlqeltn iyeelnvfer lfledqlknl kirtnriqrf iqntcneveh
     2941 kikfcrqfhe ktsalqeead siqrnellln qevnkgvkee iynlkdrlta ikccilqvlk
     3001 lkkvfdyigl nwdfsqldql qtqvfekeke leekikqldt feeehgkyqa llskmraidl
     3061 qikkmtevvl kapdsspesr rlnaqilsqr iekakclcde iikklnenkt fddsfkekei
     3121 lqiklnaeen dklykvlqnm vlelspkeld ekncqdklet slhvlnqiks qlqqpllinl
     3181 eikhiqnekd nceafqeqvw aemcsikavt aiekqreens seasdvetkl refedlqmql
     3241 ntsidlrtnv lndayenltr ykeavtrave sitsleaiii pyrvdvgnpe eslemplrkq
     3301 eelestvahi qdlteklgmi sspeaklqlq ytlqelvskn samkeafkaq eteaerylen
     3361 ykcyrkmeed iytnlskmet vlgqsmsslp lsyrealerl eqskalvsnl istkeelmkl
     3421 rqilrllrlr ctendgicll kivsalwekw lslleaakew emwceelkqe wkfvseeier
     3481 eaiildnlqe elpeisktke aatteelsel ldclcqygen vekqqllltl llqrirsiqn
     3541 vpessgavet vpafqeitsm kercnkllqk vqknkelvqt eiqerhsftk eiialknffq
     3601 qtttsfqnma fqdhpekseq feelqsilkk gkltfenime klrikysemy tivpaeiesq
     3661 veecrkaled idekisnevl ksspsyamrr kieeinnglh nvekmlqqks kniekaqeiq
     3721 kkmwdeldlw hsklneldse vqdiveqdpg qaqewmdnlm ipfqqyqqvs qraecrtsql
     3781 nkatvkmeey sdllksteaw ientshllan padydslrtl shhastvqma ledseqkhnl
     3841 lhsifmdled lsiifetdel tqsiqelsnq vtalqqkime slpqiqrmad dvvaiesevk
     3901 smekrvskik tillskeifd fspeehlkhg evilenirpm kktiaeivsy qvelrlpqtg
     3961 mkplpvfqrt nqllqdikll envtqeqnel lkvvikqtne wdeeienlkq ilnnysaqfs
     4021 lehmspdqad klpqlqgeie rmekqilsln qrkedllvdl katvlnlhqh lkqeqegver
     4081 drlpavtsee ggvaerdase rklnrrgsms ylaaveeeve essvksdngd ekaepspqsw
     4141 sslwkhdkdm eedrassssg tivqeaygki stsdnsmaqi ltpdslnteq gpecslrpnq
     4201 teegttppie adtldssdaq ggleprvekt rpeptevlha cktqvaelel wlqqanvave
     4261 petlnadmqq vleqqlvgcq amlteiehkv aflletckdq glgdngatqh eaealslklk
     4321 tvkcnlekvq mmlqekhsed qhptilkkss epehqealqp vnlselesiv terpqfsrqk
     4381 dfqqqqvlel kpmeqkdfik fiefnakkmw pqycqhdndt tqessasnqa sspendvpds
     4441 ilspqgqngd kwqylhhels skiklplpql vepqvstnmg ilpsvtmynf ryptteelkt
     4501 yttqledlrq easnlqtqen mteeayinld kklfelfltl sqclssveem lemprlyred
     4561 gsgqqvhyet lalelkklyl alsdkkgdll kamtwpgent nlllecfdnl qvclehtqaa
     4621 avcrskslka gldynrsyqn eikrlyhqli ksktslqqsl neisgqsvae qlqkadaytv
     4681 elenaesrva klrdegerlh lpyallqevy kledvldsmw gmlrarytel sspfvtesqq
     4741 dallqgmvel vkigkeklah ghlkqtkskv alqaqienhk vffqklvadm lliqaysaki
     4801 lpsllqnret fwaeqvtevk ileeksrqcg mklqsllqkw eefdenyasl ekdleilist
     4861 lpsvslveet eerlverisf yqqikrnigg kharlyqtln egkqlvasvs cpelegqiak
     4921 leeqwlslnk kidhelhrlq allkhllsyn rdsdqltkwl essqhtlnyw keqslnvsqd
     4981 ldtirsninn ffefskevde ksslktavis ignqllhlke tdtatlrasl aqfeqkwtml
     5041 itqlpdiqek lhqlqmeklp srkaitemis wmnnvehqts dedsvhspss asqvkhllqk
     5101 hkefrmemdy kqwivdfvnq sllqlstcdv eskryertef aehlgemnrq whrvhgmlnr
     5161 kiqhleqlle sitesenkiq ilnnwleaqe erlktlqkpe svisvqklll dcqdienqla
     5221 ikskaldelk qsyltlesga vplledtasr idelfqkrss vltqvnqlkt smqsvlqewk
     5281 iydqlydevn mmtirfwycm ehskpvvlsl etlrcqvenl qslqdeaess egsweklqev
     5341 igklkglcps vaeiieekcq nthkrwtqvn qaiadqlqka qsllqlwkay snahgeaaar
     5401 lkqqeakfqq lanismsgnn laeilppalq dikelqhdvq ktkeaflqns svldrlpqpa
     5461 essthmllpg plhslqraay lekmllvkan efefvlsqfk dfgvrleslk glimheeenl
     5521 drlhqqeken pdsflnhvla ltaqspdieh lnevslklpl sdvavktlqn mnrqwirata
     5581 talercselq giglnekfly ccekwiqlle kieealkvdv anslpelleq qktykmleae
     5641 vsinqtiads yvtqslqlld tteienrpef itefskltdr wqnavqgvrq rkgdvdglvr
     5701 qwqdfttsve nlfrfltdts hllsavkgqe rfslyqtrsl ihelknkeih fqrrrttcal
     5761 tleageklll ttdlktkesv grrisqlqds wkdmepqlae mikqfqstve twdqcekkik
     5821 elksrlqvlk aqsedplpel hedlhnekel ikeleqslas wtqnlkelqt mkadltrhvl
     5881 vedvmvlkeq iehlhrqwed lclrvairkq eiedrlntwv vfneknkelc awlvqmenkv
     5941 lqtadisiee mieklqkdcm eeinlfsenk lqlkqmgdql ikasnksraa eiddklnkin
     6001 drwqhlfdvi gsrvkklket fafiqqldkn msnlrtwlar ieselskpvv ydvcddqeiq
     6061 krlaeqqdlq rdieqhsagv esvfnicdvl lhdsdacane tecdsiqqtt rsldrrwrni
     6121 camsmerrmk ieetwrlwqk flddysrfed wlksaertaa cpnssevlyt sakeelkrfe
     6181 afqrqiherl tqlelinkqy rrlarenrtd tasrlkqmvh egnqrwdnlq rrvtavlrrl
     6241 rhftnqreef egtresilvw ltemdlqltn vehfsesdad dkmrqlngfq qeitlntnki
     6301 dqlivfgeql iqksepldav liedeleelh rycqevfgrv srfhrrltsc tpgledekea
     6361 senetdmedp reiqtdswrk rgeseepssp qslchlvapg hersgcetpv svdsiplewd
     6421 htgdvggsss heedeegpyy salsgksisd ghswhvpdsp scpehhykqm egdrnvppvp
     6481 passtpykpp ygklllppgt dggkegprvl ngnpqqedgg lagiteqqsg afdrwemiqa
     6541 qelhnklkik qnlqqlnsdi saittwlkkt eaelemlkma kppsdiqeie lrvkrlqeil
     6601 kafdtykalv vsvnvsskef lqtespeste lqsrlrqlsl lweaaqgavd swrgglrqsl
     6661 mqcqgsktrp rsdvlffkdf hqlsqnlllw lasaknrrqk ahvtdpkadp rallecrrel
     6721 mqlekelver qpqvdmlqei snsllikghg edcieaeekv hviekklkql reqvsqdlma
     6781 lqgtqnpasp lpsfdevdsg dqppatsvpa prakfravrt tegeeetesr vpgstrpqrs
     6841 flsrvvraal plqlllllll llacllpsse edysctqann farsfypmlr ytngpppt
//
LOCUS       XP_047287112            6898 aa            linear   PRI 05-AUG-2025
DEFINITION  nesprin-2 isoform X13 [Homo sapiens].
ACCESSION   XP_047287112
VERSION     XP_047287112.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431156.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..6898
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..6898
                     /product="nesprin-2 isoform X13"
                     /calculated_mol_wt=797771
     Region          28..138
                     /region_name="CH_SYNE2_rpt1"
                     /note="first calponin homology (CH) domain found in
                     synaptic nuclear envelope protein 2; cd21242"
                     /db_xref="CDD:409091"
     Site            order(33,37,89,91..92,95..96,98,107..115,120,122..123,
                     125..126,129..130,133)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409091"
     Region          178..286
                     /region_name="CH_SYNE2_rpt2"
                     /note="second calponin homology (CH) domain found in
                     synaptic nuclear envelope protein 2 (SYNE-2) and similar
                     proteins; cd21244"
                     /db_xref="CDD:409093"
     Site            order(183,187,237,239..240,243..244,246,255..263,270,
                     272..273,275..276,279..280,283)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409093"
     Region          <1418..2014
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          <1868..>2369
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          <2338..2712
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          2805..>3389
                     /region_name="CCDC158"
                     /note="Coiled-coil domain-containing protein 158;
                     pfam15921"
                     /db_xref="CDD:464943"
     Region          <3656..>3950
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <3811..4113
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <4496..5321
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          4945..5169
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            5054..5059
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5063..5276
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Region          5123..>5875
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Site            5168..5173
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5178..5384
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cl02488"
                     /db_xref="CDD:413338"
     Site            5275..5280
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5919..6133
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6020..6025
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          6137..6350
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6243..6248
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          6567..6776
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6673..6678
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          <6867..6898
                     /region_name="KASH"
                     /note="Nuclear envelope localization domain; pfam10541"
                     /db_xref="CDD:463142"
     CDS             1..6898
                     /gene="SYNE2"
                     /gene_synonym="EDMD5; KASH2; Nesp2; Nesprin-2; NUA;
                     NUANCE; SYNE-2; TROPH"
                     /coded_by="XM_047431156.1:192..20888"
                     /db_xref="GeneID:23224"
                     /db_xref="HGNC:HGNC:17084"
                     /db_xref="MIM:608442"
ORIGIN      
        1 masspelpte deqgswgidd lhislqaeqe dtqkkaftcw insqlarhts psvisdlftd
       61 ikkghvlldl levlsgqqlp rdkgsntfqc riniehaltf lrnrsiklin ihvtdiidgn
      121 psiilgliwt iilhfhiekl aqtlscnynq pslddvsvvd sspassppak kcskvqarwq
      181 msarkalllw aqeqcatyes vnvtdfkssw rngmaflaii halrpdlidm ksvkhrsnkd
      241 nlreafriae qelkiprlle pedvdvvdpd eksimtyvaq flqyskdapg tgeeaqgkvk
      301 damgwltlqk eklqkllkds endtyfkkyn sllsfmesfn eekksfldvl sikrdldeld
      361 kdhlqlreaw dgldhqinaw kiklnyalpp plhqteawlq eveelmdedl sasqdhsqav
      421 tliqekmtlf kslmdrfehh snilltfenk denhlplvpp nkleemkrri nnilekkfil
      481 llefhyykcl vlglvdevks kldiwnikyg sresvellle dwhkfieeke flarldtsfq
      541 kcgeiyknla gecqninkqy mmvksdvcmy rkniynvkst lqkvlacwat yvenlrllra
      601 cfeetkkeei kevpfetlaq wnlehatlne agnflvevsn dvvgssiske lrrlnkrwrk
      661 lvsktqlemn lplmikkqdq ptfdnsgnil skeekatvef stdmsvelpe nynqnikage
      721 khekeneeft gqlkvakdve kligqveiwe aeaksvldqd dvdtsmeesl khliakgsmf
      781 delmarsedm lqmdiqniss qesfqhvltt glqakiqeak ekvqinvvkl iaalknltdv
      841 spdldirlkm eesqkelesy mmraqqllgq respgelisk hkealiisnt kslakylkav
      901 eelknnvted ikmsleeksr dvcakweslh helslyvqql kidiekgkls dnilklekqi
      961 nkekklirrg rtkglikehe acfseegcly qlnhhmevlr elceelpsqk sqqevkrllk
     1021 dyeqkierll kcaseihmtl qptaggtskn egtittsenr ggdphseapf aksdnqpste
     1081 kameptmkfs lasvlrplqe esimekdysa sinslleryd tyrdilehhl qnnkfritsd
     1141 fsseedrsss clqakltdlq viknetdarw kefeiislkl enhvndikkp fvikerdtlk
     1201 ererelqmtl ntrmesleta lrlvlpveka slllcgsdlp lhkmaiqgfh lidadriyqh
     1261 lrniqdsiak qieicnrlee pgnfvlkelh pfdlhamqni ilkyktqfeg mnhrvqrsed
     1321 tlkaledfla slrtaklsae pvtdlsasdt qvaqentltv knkegeihlm kdkakhldkc
     1381 lkmldmsfkd aergddtsce nlldafsikl sethgygvqe efteenklle acifknnell
     1441 kniqdvqsqi skiglkdptv pavkhrkksl irldkvldey eeekrhlqem anslphfkdg
     1501 rektvnqqcq ntvvlwentk alvtecleqc grvlellkqy qnfksilttl iqkeesvisl
     1561 qasymgkenl kkriaeieiv keefnehlev vdkinqvckn lqfylnkmkt feeppfekea
     1621 niivdrwldi nektedyyen lgralalwdk lfnlknvide wtekalqkme lhqlteedre
     1681 rlkeelqvhe qktsefsrrv aeiqfllqss eiplelqvme ssilnkmehv qkcltgesnc
     1741 halsgstael redldqaktq igmtesllka lspsdsleif tkleeiqqqi lqqkhsmill
     1801 enqigcltpe lselkkqyes vsdlfntkks vlqdhfskll ndqcknfndw fsnikvnlke
     1861 cfessetkks veqklqklsd fltlegrnsk ikqvdsvlkh vkkhlpkahv keliswlvgq
     1921 efelekmesi cqarakeled slqqllrlqd dhrnlrkwlt nqeekwkgme epgektelfc
     1981 qalarkreqf esvaqlnnsl keygfteeee iimeatclmd ryqtllrqls eieeedkllp
     2041 tedqsfndla hdvihwikei keslmvlnss egkmpleeri qkikeiillk pegdarieti
     2101 mkqaesseap lvqktltdis nqwdntlhla stylshqekl llegekylqs kedlrlmlie
     2161 lkkkqeagfa lqhglqekka qlkiykkflk kaqdltsllk elksqgnyll ectknpsfse
     2221 epwleikhlh esllqqlqds vqnldghvre hdsyqvcvtd lnttldnfsk efvsfsdkpv
     2281 dqiaveeklq klqelenrls lqdgtlkkil alaksvkqnt ssvgqkiikd dikslqckqk
     2341 dlenrlasak qemecclnsi lkskrstekk gkftlpgrek qatsdvqest qesaavekle
     2401 edweinkdsa vemamskqls lnaqesmknt ederkvnelq nqpleldtml rneqleeiek
     2461 lytqleakka aikpleqtec lnktetgalv lhnigysaqh ldnllqalit lkknkesqyc
     2521 vlrdfqeyla avessmkall tdkeslkvgp ldsvtyldki kkfiasieke kdslgnlkik
     2581 wenlsnhvtd mdkkllesqi kqlehgweqv eqqiqkkysq qvveydeftt lmnkvqdtei
     2641 slqqqqqhlq lrlkspeera gnqsmialtt dlqatkhgfs vlkgqaelqm kriwgekekk
     2701 nledginnlk kqwetleplh leaenqikkc dirnkmketi lwaknllgel npsipllpdd
     2761 ilsqirkckv thdgilarqq sveslaeevk dkvpslttye gsdlnntled lrnqyqmlvl
     2821 kstqrsqqle fkleersnff aiirkfqlmv qesetliipr vetaateael khhhvtleas
     2881 qkelqeidsg isthlqeltn iyeelnvfer lfledqlknl kirtnriqrf iqntcneveh
     2941 kikfcrqfhe ktsalqeead siqrnellln qevnkgvkee iynlkdrlta ikccilqvlk
     3001 lkkvfdyigl nwdfsqldql qtqvfekeke leekikqldt feeehgkyqa llskmraidl
     3061 qikkmtevvl kapdsspesr rlnaqilsqr iekakclcde iikklnenkt fddsfkekei
     3121 lqiklnaeen dklykvlqnm vlelspkeld ekncqdklet slhvlnqiks qlqqpllinl
     3181 eikhiqnekd nceafqeqvw aemcsikavt aiekqreens seasdvetkl refedlqmql
     3241 ntsidlrtnv lndayenltr ykeavtrave sitsleaiii pyrvdvgnpe eslemplrkq
     3301 eelestvahi qdlteklgmi sspeaklqlq ytlqelvskn samkeafkaq eteaerylen
     3361 ykcyrkmeed iytnlskmet vlgqsmsslp lsyrealerl eqskalvsnl istkeelmkl
     3421 rqilrllrlr ctendgicll kivsalwekw lslleaakew emwceelkqe wkfvseeier
     3481 eaiildnlqe elpeisktke aatteelsel ldclcqygen vekqqllltl llqrirsiqn
     3541 vpessgavet vpafqeitsm kercnkllqk vqknkelvqt eiqerhsftk eiialknffq
     3601 qtttsfqnma fqdhpekseq feelqsilkk gkltfenime klrikysemy tivpaeiesq
     3661 veecrkaled idekisnevl ksspsyamrr kieeinnglh nvekmlqqks kniekaqeiq
     3721 kkmwdeldlw hsklneldse vqdiveqdpg qaqewmdnlm ipfqqyqqvs qraecrtsql
     3781 nkatvkmeey sdllksteaw ientshllan padydslrtl shhastvqma ledseqkhnl
     3841 lhsifmdled lsiifetdel tqsiqelsnq vtalqqkime slpqiqrmad dvvaiesevk
     3901 smekrvskik tillskeifd fspeehlkhg evilenirpm kktiaeivsy qvelrlpqtg
     3961 mkplpvfqrt nqllqdikll envtqeqnel lkvvikqtne wdeeienlkq ilnnysaqfs
     4021 lehmspdqad klpqlqgeie rmekqilsln qrkedllvdl katvlnlhqh lkqeqegver
     4081 drlpavtsee ggvaerdase rklnrrgsms ylaaveeeve essvksdngd ekaepspqsw
     4141 sslwkhdkdm eedrassssg tivqeaygki stsdnsmaqi ltpdslnteq gpecslrpnq
     4201 teegttppie adtldssdaq ggleprvekt rpeptevlha cktqvaelel wlqqanvave
     4261 petlnadmqq vleqqlvgcq amlteiehkv aflletckdq glgdngatqh eaealslklk
     4321 tvkcnlekvq mmlqekhsed qhptilkkss epehqealqp vnlselesiv terpqfsrqk
     4381 dfqqqqvlel kpmeqkdfik fiefnakkmw pqycqhdndt tqessasnqa sspendvpds
     4441 ilspqgqngd kwqylhhels skiklplpql vepqvstnmg ilpsvtmynf ryptteelkt
     4501 yttqledlrq easnlqtqen mteeayinld kklfelfltl sqclssveem lemprlyred
     4561 gsgqqvhyet lalelkklyl alsdkkgdll kamtwpgent nlllecfdnl qvclehtqaa
     4621 avcrskslka gldynrsyqn eikrlyhqli ksktslqqsl neisgqsvae qlqkadaytv
     4681 elenaesrva klrdegerlh lpyallqevy kledvldsmw gmlrarytel sspfvtesqq
     4741 dallqgmvel vkigkeklah ghlkqtkskv alqaqienhk vffqklvadm lliqaysaki
     4801 lpsllqnret fwaeqvtevk ileeksrqcg mklqsllqkw eefdenyasl ekdleilist
     4861 lpsvslveet eerlverisf yqqikrnigg kharlyqtln egkqlvasvs cpelegqiak
     4921 leeqwlslnk kidhelhrlq allkhllsyn rdsdqltkwl essqhtlnyw keqslnvsqd
     4981 ldtirsninn ffefskevde ksslktavis ignqllhlke tdtatlrasl aqfeqkwtml
     5041 itqlpdiqek lhqlqmeklp srkaitemis wmnnvehqts dedsvhspss asqvkhllqk
     5101 hkefrmemdy kqwivdfvnq sllqlstcdv eskryertef aehlgemnrq whrvhgmlnr
     5161 kiqhleqlle sitesenkiq ilnnwleaqe erlktlqkpe svisvqklll dcqdienqla
     5221 ikskaldelk qsyltlesga vplledtasr idelfqkrss vltqvnqlkt smqsvlqewk
     5281 iydqlydevn mmtirfwycm ehskpvvlsl etlrcqvenl qslqdeaess egsweklqev
     5341 igklkglcps vaeiieekcq nthkrwtqvn qaiadqlqka qsllqlwkay snahgeaaar
     5401 lkqqeakfqq lanismsgnn laeilppalq dikelqhdvq ktkeaflqns svldrlpqpa
     5461 essthmllpg plhslqraay lekmllvkan efefvlsqfk dfgvrleslk glimheeenl
     5521 drlhqqeken pdsflnhvla ltaqspdieh lnevslklpl sdvavktlqn mnrqwirata
     5581 talercselq giglnekfly ccekwiqlle kieealkvdv anslpelleq qktykmleae
     5641 vsinqtiads yvtqslqlld tteienrpef itefskltdr wqnavqgvrq rkgdvdglvr
     5701 qwqdfttsve nlfrfltdts hllsavkgqe rfslyqtrsl ihelknkeih fqrrrttcal
     5761 tleageklll ttdlktkesv grrisqlqds wkdmepqlae mikqfqstve twdqcekkik
     5821 elksrlqvlk aqsedplpel hedlhnekel ikeleqslas wtqnlkelqt mkadltrhvl
     5881 vedvmvlkeq iehlhrqwed lclrvairkq eiedrlntwv vfneknkelc awlvqmenkv
     5941 lqtadisiee mieklqkdcm eeinlfsenk lqlkqmgdql ikasnksraa eiddklnkin
     6001 drwqhlfdvi gsrvkklket fafiqqldkn msnlrtwlar ieselskpvv ydvcddqeiq
     6061 krlaeqqdlq rdieqhsagv esvfnicdvl lhdsdacane tecdsiqqtt rsldrrwrni
     6121 camsmerrmk ieetwrlwqk flddysrfed wlksaertaa cpnssevlyt sakeelkrfe
     6181 afqrqiherl tqlelinkqy rrlarenrtd tasrlkqmvh egnqrwdnlq rrvtavlrrl
     6241 rhftnqreef egtresilvw ltemdlqltn vehfsesdad dkmrqlngfq qeitlntnki
     6301 dqlivfgeql iqksepldav liedeleelh rycqevfgrv srfhrrltsc tpgledekea
     6361 senetdmedp reiqtdswrk rgeseepssp qslchlvapg hersgcetpv svdsiplewd
     6421 htgdvggsss heedeegpyy salsgksisd ghswhvpdsp scpehhykqm egdrnvppvp
     6481 passtpykpp ygklllppgt dggkegprvl ngnpqqedgg lagiteqqsg tacnwqssre
     6541 aeygafdrwe miqaqelhnk lkikqnlqql nsdisaittw lkkteaelem lkmakppsdi
     6601 qeielrvkrl qeilkafdty kalvvsvnvs skeflqtesp estelqsrlr qlsllweaaq
     6661 gavdswrggl rqslmqcqdf hqlsqnlllw lasaknrrqk ahvtdpkadp rallecrrel
     6721 mqlekelver qpqvdmlqei snsllikghg edcieaeekv hviekklkql reqvsqdlma
     6781 lqgtqnpasp lpsfdevdsg dqppatsvpa prakfravrt tegeeetesr vpgstrpqrs
     6841 flsrvvraal plqlllllll llacllpsse edysctqann farsfypmlr ytngpppt
//
LOCUS       XP_011534884            6897 aa            linear   PRI 05-AUG-2025
DEFINITION  nesprin-2 isoform X14 [Homo sapiens].
ACCESSION   XP_011534884
VERSION     XP_011534884.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536582.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..6897
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..6897
                     /product="nesprin-2 isoform X14"
                     /calculated_mol_wt=797829
     Region          28..138
                     /region_name="CH_SYNE2_rpt1"
                     /note="first calponin homology (CH) domain found in
                     synaptic nuclear envelope protein 2; cd21242"
                     /db_xref="CDD:409091"
     Site            order(33,37,89,91..92,95..96,98,107..115,120,122..123,
                     125..126,129..130,133)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409091"
     Region          178..286
                     /region_name="CH_SYNE2_rpt2"
                     /note="second calponin homology (CH) domain found in
                     synaptic nuclear envelope protein 2 (SYNE-2) and similar
                     proteins; cd21244"
                     /db_xref="CDD:409093"
     Site            order(183,187,237,239..240,243..244,246,255..263,270,
                     272..273,275..276,279..280,283)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409093"
     Region          <1418..2014
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          <1868..2417
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          <2338..2712
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          2805..>3389
                     /region_name="CCDC158"
                     /note="Coiled-coil domain-containing protein 158;
                     pfam15921"
                     /db_xref="CDD:464943"
     Region          <3656..>3950
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <3811..4113
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <4457..5282
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          4906..5130
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            5015..5020
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5024..5237
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Region          5084..>5836
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Site            5129..5134
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5139..5345
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cl02488"
                     /db_xref="CDD:413338"
     Site            5236..5241
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5880..6094
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            5981..5986
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          6098..6311
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6204..6209
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          6551..6774
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6657..6662
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          <6866..6897
                     /region_name="KASH"
                     /note="Nuclear envelope localization domain; pfam10541"
                     /db_xref="CDD:463142"
     CDS             1..6897
                     /gene="SYNE2"
                     /gene_synonym="EDMD5; KASH2; Nesp2; Nesprin-2; NUA;
                     NUANCE; SYNE-2; TROPH"
                     /coded_by="XM_011536582.2:192..20885"
                     /db_xref="GeneID:23224"
                     /db_xref="HGNC:HGNC:17084"
                     /db_xref="MIM:608442"
ORIGIN      
        1 masspelpte deqgswgidd lhislqaeqe dtqkkaftcw insqlarhts psvisdlftd
       61 ikkghvlldl levlsgqqlp rdkgsntfqc riniehaltf lrnrsiklin ihvtdiidgn
      121 psiilgliwt iilhfhiekl aqtlscnynq pslddvsvvd sspassppak kcskvqarwq
      181 msarkalllw aqeqcatyes vnvtdfkssw rngmaflaii halrpdlidm ksvkhrsnkd
      241 nlreafriae qelkiprlle pedvdvvdpd eksimtyvaq flqyskdapg tgeeaqgkvk
      301 damgwltlqk eklqkllkds endtyfkkyn sllsfmesfn eekksfldvl sikrdldeld
      361 kdhlqlreaw dgldhqinaw kiklnyalpp plhqteawlq eveelmdedl sasqdhsqav
      421 tliqekmtlf kslmdrfehh snilltfenk denhlplvpp nkleemkrri nnilekkfil
      481 llefhyykcl vlglvdevks kldiwnikyg sresvellle dwhkfieeke flarldtsfq
      541 kcgeiyknla gecqninkqy mmvksdvcmy rkniynvkst lqkvlacwat yvenlrllra
      601 cfeetkkeei kevpfetlaq wnlehatlne agnflvevsn dvvgssiske lrrlnkrwrk
      661 lvsktqlemn lplmikkqdq ptfdnsgnil skeekatvef stdmsvelpe nynqnikage
      721 khekeneeft gqlkvakdve kligqveiwe aeaksvldqd dvdtsmeesl khliakgsmf
      781 delmarsedm lqmdiqniss qesfqhvltt glqakiqeak ekvqinvvkl iaalknltdv
      841 spdldirlkm eesqkelesy mmraqqllgq respgelisk hkealiisnt kslakylkav
      901 eelknnvted ikmsleeksr dvcakweslh helslyvqql kidiekgkls dnilklekqi
      961 nkekklirrg rtkglikehe acfseegcly qlnhhmevlr elceelpsqk sqqevkrllk
     1021 dyeqkierll kcaseihmtl qptaggtskn egtittsenr ggdphseapf aksdnqpste
     1081 kameptmkfs lasvlrplqe esimekdysa sinslleryd tyrdilehhl qnnkfritsd
     1141 fsseedrsss clqakltdlq viknetdarw kefeiislkl enhvndikkp fvikerdtlk
     1201 ererelqmtl ntrmesleta lrlvlpveka slllcgsdlp lhkmaiqgfh lidadriyqh
     1261 lrniqdsiak qieicnrlee pgnfvlkelh pfdlhamqni ilkyktqfeg mnhrvqrsed
     1321 tlkaledfla slrtaklsae pvtdlsasdt qvaqentltv knkegeihlm kdkakhldkc
     1381 lkmldmsfkd aergddtsce nlldafsikl sethgygvqe efteenklle acifknnell
     1441 kniqdvqsqi skiglkdptv pavkhrkksl irldkvldey eeekrhlqem anslphfkdg
     1501 rektvnqqcq ntvvlwentk alvtecleqc grvlellkqy qnfksilttl iqkeesvisl
     1561 qasymgkenl kkriaeieiv keefnehlev vdkinqvckn lqfylnkmkt feeppfekea
     1621 niivdrwldi nektedyyen lgralalwdk lfnlknvide wtekalqkme lhqlteedre
     1681 rlkeelqvhe qktsefsrrv aeiqfllqss eiplelqvme ssilnkmehv qkcltgesnc
     1741 halsgstael redldqaktq igmtesllka lspsdsleif tkleeiqqqi lqqkhsmill
     1801 enqigcltpe lselkkqyes vsdlfntkks vlqdhfskll ndqcknfndw fsnikvnlke
     1861 cfessetkks veqklqklsd fltlegrnsk ikqvdsvlkh vkkhlpkahv keliswlvgq
     1921 efelekmesi cqarakeled slqqllrlqd dhrnlrkwlt nqeekwkgme epgektelfc
     1981 qalarkreqf esvaqlnnsl keygfteeee iimeatclmd ryqtllrqls eieeedkllp
     2041 tedqsfndla hdvihwikei keslmvlnss egkmpleeri qkikeiillk pegdarieti
     2101 mkqaesseap lvqktltdis nqwdntlhla stylshqekl llegekylqs kedlrlmlie
     2161 lkkkqeagfa lqhglqekka qlkiykkflk kaqdltsllk elksqgnyll ectknpsfse
     2221 epwleikhlh esllqqlqds vqnldghvre hdsyqvcvtd lnttldnfsk efvsfsdkpv
     2281 dqiaveeklq klqelenrls lqdgtlkkil alaksvkqnt ssvgqkiikd dikslqckqk
     2341 dlenrlasak qemecclnsi lkskrstekk gkftlpgrek qatsdvqest qesaavekle
     2401 edweinkdsa vemamskqls lnaqesmknt ederkvnelq nqpleldtml rneqleeiek
     2461 lytqleakka aikpleqtec lnktetgalv lhnigysaqh ldnllqalit lkknkesqyc
     2521 vlrdfqeyla avessmkall tdkeslkvgp ldsvtyldki kkfiasieke kdslgnlkik
     2581 wenlsnhvtd mdkkllesqi kqlehgweqv eqqiqkkysq qvveydeftt lmnkvqdtei
     2641 slqqqqqhlq lrlkspeera gnqsmialtt dlqatkhgfs vlkgqaelqm kriwgekekk
     2701 nledginnlk kqwetleplh leaenqikkc dirnkmketi lwaknllgel npsipllpdd
     2761 ilsqirkckv thdgilarqq sveslaeevk dkvpslttye gsdlnntled lrnqyqmlvl
     2821 kstqrsqqle fkleersnff aiirkfqlmv qesetliipr vetaateael khhhvtleas
     2881 qkelqeidsg isthlqeltn iyeelnvfer lfledqlknl kirtnriqrf iqntcneveh
     2941 kikfcrqfhe ktsalqeead siqrnellln qevnkgvkee iynlkdrlta ikccilqvlk
     3001 lkkvfdyigl nwdfsqldql qtqvfekeke leekikqldt feeehgkyqa llskmraidl
     3061 qikkmtevvl kapdsspesr rlnaqilsqr iekakclcde iikklnenkt fddsfkekei
     3121 lqiklnaeen dklykvlqnm vlelspkeld ekncqdklet slhvlnqiks qlqqpllinl
     3181 eikhiqnekd nceafqeqvw aemcsikavt aiekqreens seasdvetkl refedlqmql
     3241 ntsidlrtnv lndayenltr ykeavtrave sitsleaiii pyrvdvgnpe eslemplrkq
     3301 eelestvahi qdlteklgmi sspeaklqlq ytlqelvskn samkeafkaq eteaerylen
     3361 ykcyrkmeed iytnlskmet vlgqsmsslp lsyrealerl eqskalvsnl istkeelmkl
     3421 rqilrllrlr ctendgicll kivsalwekw lslleaakew emwceelkqe wkfvseeier
     3481 eaiildnlqe elpeisktke aatteelsel ldclcqygen vekqqllltl llqrirsiqn
     3541 vpessgavet vpafqeitsm kercnkllqk vqknkelvqt eiqerhsftk eiialknffq
     3601 qtttsfqnma fqdhpekseq feelqsilkk gkltfenime klrikysemy tivpaeiesq
     3661 veecrkaled idekisnevl ksspsyamrr kieeinnglh nvekmlqqks kniekaqeiq
     3721 kkmwdeldlw hsklneldse vqdiveqdpg qaqewmdnlm ipfqqyqqvs qraecrtsql
     3781 nkatvkmeey sdllksteaw ientshllan padydslrtl shhastvqma ledseqkhnl
     3841 lhsifmdled lsiifetdel tqsiqelsnq vtalqqkime slpqiqrmad dvvaiesevk
     3901 smekrvskik tillskeifd fspeehlkhg evilenirpm kktiaeivsy qvelrlpqtg
     3961 mkplpvfqrt nqllqdikll envtqeqnel lkvvikqtne wdeeienlkq ilnnysaqfs
     4021 lehmspdqad klpqlqgeie rmekqilsln qrkedllvdl katvlnlhqh lkqeqegver
     4081 drlpavtsee ggvaerdase rklnrrgsms ylaaveeeve essvksdngd ekaepspqsw
     4141 sslwkhdkdm eedrassssg tivqgttppi eadtldssda qggleprvek trpeptevlh
     4201 acktqvaele lwlqqanvav epetlnadmq qvleqqlvgc qamlteiehk vaflletckd
     4261 qglgdngatq heaealslkl ktvkcnlekv qmmlqekhse dqhptilkks sepehqealq
     4321 pvnlselesi vterpqfsrq kdfqqqqvle lkpmeqkdfi kfiefnakkm wpqycqhdnd
     4381 ttqessasnq asspendvpd silspqgqng dkwqylhhel sskiklplpq lvepqvstnm
     4441 gilpsvtmyn fryptteelk tyttqledlr qeasnlqtqe nmteeayinl dkklfelflt
     4501 lsqclssvee mlemprlyre dgsgqqvhye tlalelkkly lalsdkkgdl lkamtwpgen
     4561 tnlllecfdn lqvclehtqa aavcrskslk agldynrsyq neikrlyhql iksktslqqs
     4621 lneisgqsva eqlqkadayt velenaesrv aklrdegerl hlpyallqev ykledvldsm
     4681 wgmlraryte lsspfvtesq qdallqgmve lvkigkekla hghlkqtksk valqaqienh
     4741 kvffqklvad mlliqaysak ilpsllqnre tfwaeqvtev kileeksrqc gmklqsllqk
     4801 weefdenyas lekdleilis tlpsvslvee teerlveris fyqqikrnig gkharlyqtl
     4861 negkqlvasv scpelegqia kleeqwlsln kkidhelhrl qallkhllsy nrdsdqltkw
     4921 lessqhtlny wkeqslnvsq dldtirsnin nffefskevd eksslktavi signqllhlk
     4981 etdtatlras laqfeqkwtm litqlpdiqe klhqlqmekl psrkaitemi swmnnvehqt
     5041 sdedsvhsps sasqvkhllq khkefrmemd ykqwivdfvn qsllqlstcd veskryerte
     5101 faehlgemnr qwhrvhgmln rkiqhleqll esitesenki qilnnwleaq eerlktlqkp
     5161 esvisvqkll ldcqdienql aikskaldel kqsyltlesg avplledtas ridelfqkrs
     5221 svltqvnqlk tsmqsvlqew kiydqlydev nmmtirfwyc mehskpvvls letlrcqven
     5281 lqslqdeaes segsweklqe vigklkglcp svaeiieekc qnthkrwtqv nqaiadqlqk
     5341 aqsllqlwka ysnahgeaaa rlkqqeakfq qlanismsgn nlaeilppal qdikelqhdv
     5401 qktkeaflqn ssvldrlpqp aessthmllp gplhslqraa ylekmllvka nefefvlsqf
     5461 kdfgvrlesl kglimheeen ldrlhqqeke npdsflnhvl altaqspdie hlnevslklp
     5521 lsdvavktlq nmnrqwirat atalercsel qgiglnekfl yccekwiqll ekieealkvd
     5581 vanslpelle qqktykmlea evsinqtiad syvtqslqll dtteienrpe fitefskltd
     5641 rwqnavqgvr qrkgdvdglv rqwqdfttsv enlfrfltdt shllsavkgq erfslyqtrs
     5701 lihelknkei hfqrrrttca ltleagekll lttdlktkes vgrrisqlqd swkdmepqla
     5761 emikqfqstv etwdqcekki kelksrlqvl kaqsedplpe lhedlhneke likeleqsla
     5821 swtqnlkelq tmkadltrhv lvedvmvlke qiehlhrqwe dlclrvairk qeiedrlntw
     5881 vvfneknkel cawlvqmenk vlqtadisie emieklqkdc meeinlfsen klqlkqmgdq
     5941 likasnksra aeiddklnki ndrwqhlfdv igsrvkklke tfafiqqldk nmsnlrtwla
     6001 rieselskpv vydvcddqei qkrlaeqqdl qrdieqhsag vesvfnicdv llhdsdacan
     6061 etecdsiqqt trsldrrwrn icamsmerrm kieetwrlwq kflddysrfe dwlksaerta
     6121 acpnssevly tsakeelkrf eafqrqiher ltqlelinkq yrrlarenrt dtasrlkqmv
     6181 hegnqrwdnl qrrvtavlrr lrhftnqree fegtresilv wltemdlqlt nvehfsesda
     6241 ddkmrqlngf qqeitlntnk idqlivfgeq liqkseplda vliedeleel hrycqevfgr
     6301 vsrfhrrlts ctpgledeke asenetdmed preiqtdswr krgeseepss pqslchlvap
     6361 ghersgcetp vsvdsiplew dhtgdvggss sheedeegpy ysalsdveip enpeaylkmt
     6421 tktlkassgk sisdghswhv pdspscpehh ykqmegdrnv ppvppasstp ykppygklll
     6481 ppgtdggkeg prvlngnpqq edgglagite qqsgtacnwq ssreaeygaf drwemiqaqe
     6541 lhnklkikqn lqqlnsdisa ittwlkktea elemlkmakp psdiqeielr vkrlqeilka
     6601 fdtykalvvs vnvsskeflq tespestelq srlrqlsllw eaaqgavdsw rgglrqslmq
     6661 cqgsktrprs dvlffkdfhq lsqnlllwla saknrrqkah vtdpkadpra llecrrelmq
     6721 lekelverqp qvdmlqeisn sllikghged cieaeekvhv iekklkqlre qvsqdlmalq
     6781 gtqnpasplp sfdevdsgdq ppatsvpapr akqfravrtt egeeetesrv pgstrpqrsf
     6841 lsrvvraalp lqllllllll lacllpssee dysctqannf arsfypmlry tngpppt
//
LOCUS       XP_005267516            6884 aa            linear   PRI 05-AUG-2025
DEFINITION  nesprin-2 isoform X15 [Homo sapiens].
ACCESSION   XP_005267516
VERSION     XP_005267516.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267459.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..6884
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..6884
                     /product="nesprin-2 isoform X15"
                     /calculated_mol_wt=796187
     Region          28..138
                     /region_name="CH_SYNE2_rpt1"
                     /note="first calponin homology (CH) domain found in
                     synaptic nuclear envelope protein 2; cd21242"
                     /db_xref="CDD:409091"
     Site            order(33,37,89,91..92,95..96,98,107..115,120,122..123,
                     125..126,129..130,133)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409091"
     Region          178..286
                     /region_name="CH_SYNE2_rpt2"
                     /note="second calponin homology (CH) domain found in
                     synaptic nuclear envelope protein 2 (SYNE-2) and similar
                     proteins; cd21244"
                     /db_xref="CDD:409093"
     Site            order(183,187,237,239..240,243..244,246,255..263,270,
                     272..273,275..276,279..280,283)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409093"
     Region          <1418..2014
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          <1868..2417
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          <2338..2712
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          2805..>3389
                     /region_name="CCDC158"
                     /note="Coiled-coil domain-containing protein 158;
                     pfam15921"
                     /db_xref="CDD:464943"
     Region          <3656..>3950
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <3811..4113
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <4496..5321
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          4945..5169
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            5054..5059
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5063..5276
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Region          5123..>5875
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Site            5168..5173
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5178..5384
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cl02488"
                     /db_xref="CDD:413338"
     Site            5275..5280
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5919..6133
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6020..6025
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          6137..6350
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6243..6248
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          6553..6762
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6659..6664
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          <6853..6884
                     /region_name="KASH"
                     /note="Nuclear envelope localization domain; pfam10541"
                     /db_xref="CDD:463142"
     CDS             1..6884
                     /gene="SYNE2"
                     /gene_synonym="EDMD5; KASH2; Nesp2; Nesprin-2; NUA;
                     NUANCE; SYNE-2; TROPH"
                     /coded_by="XM_005267459.2:192..20846"
                     /db_xref="GeneID:23224"
                     /db_xref="HGNC:HGNC:17084"
                     /db_xref="MIM:608442"
ORIGIN      
        1 masspelpte deqgswgidd lhislqaeqe dtqkkaftcw insqlarhts psvisdlftd
       61 ikkghvlldl levlsgqqlp rdkgsntfqc riniehaltf lrnrsiklin ihvtdiidgn
      121 psiilgliwt iilhfhiekl aqtlscnynq pslddvsvvd sspassppak kcskvqarwq
      181 msarkalllw aqeqcatyes vnvtdfkssw rngmaflaii halrpdlidm ksvkhrsnkd
      241 nlreafriae qelkiprlle pedvdvvdpd eksimtyvaq flqyskdapg tgeeaqgkvk
      301 damgwltlqk eklqkllkds endtyfkkyn sllsfmesfn eekksfldvl sikrdldeld
      361 kdhlqlreaw dgldhqinaw kiklnyalpp plhqteawlq eveelmdedl sasqdhsqav
      421 tliqekmtlf kslmdrfehh snilltfenk denhlplvpp nkleemkrri nnilekkfil
      481 llefhyykcl vlglvdevks kldiwnikyg sresvellle dwhkfieeke flarldtsfq
      541 kcgeiyknla gecqninkqy mmvksdvcmy rkniynvkst lqkvlacwat yvenlrllra
      601 cfeetkkeei kevpfetlaq wnlehatlne agnflvevsn dvvgssiske lrrlnkrwrk
      661 lvsktqlemn lplmikkqdq ptfdnsgnil skeekatvef stdmsvelpe nynqnikage
      721 khekeneeft gqlkvakdve kligqveiwe aeaksvldqd dvdtsmeesl khliakgsmf
      781 delmarsedm lqmdiqniss qesfqhvltt glqakiqeak ekvqinvvkl iaalknltdv
      841 spdldirlkm eesqkelesy mmraqqllgq respgelisk hkealiisnt kslakylkav
      901 eelknnvted ikmsleeksr dvcakweslh helslyvqql kidiekgkls dnilklekqi
      961 nkekklirrg rtkglikehe acfseegcly qlnhhmevlr elceelpsqk sqqevkrllk
     1021 dyeqkierll kcaseihmtl qptaggtskn egtittsenr ggdphseapf aksdnqpste
     1081 kameptmkfs lasvlrplqe esimekdysa sinslleryd tyrdilehhl qnnkfritsd
     1141 fsseedrsss clqakltdlq viknetdarw kefeiislkl enhvndikkp fvikerdtlk
     1201 ererelqmtl ntrmesleta lrlvlpveka slllcgsdlp lhkmaiqgfh lidadriyqh
     1261 lrniqdsiak qieicnrlee pgnfvlkelh pfdlhamqni ilkyktqfeg mnhrvqrsed
     1321 tlkaledfla slrtaklsae pvtdlsasdt qvaqentltv knkegeihlm kdkakhldkc
     1381 lkmldmsfkd aergddtsce nlldafsikl sethgygvqe efteenklle acifknnell
     1441 kniqdvqsqi skiglkdptv pavkhrkksl irldkvldey eeekrhlqem anslphfkdg
     1501 rektvnqqcq ntvvlwentk alvtecleqc grvlellkqy qnfksilttl iqkeesvisl
     1561 qasymgkenl kkriaeieiv keefnehlev vdkinqvckn lqfylnkmkt feeppfekea
     1621 niivdrwldi nektedyyen lgralalwdk lfnlknvide wtekalqkme lhqlteedre
     1681 rlkeelqvhe qktsefsrrv aeiqfllqss eiplelqvme ssilnkmehv qkcltgesnc
     1741 halsgstael redldqaktq igmtesllka lspsdsleif tkleeiqqqi lqqkhsmill
     1801 enqigcltpe lselkkqyes vsdlfntkks vlqdhfskll ndqcknfndw fsnikvnlke
     1861 cfessetkks veqklqklsd fltlegrnsk ikqvdsvlkh vkkhlpkahv keliswlvgq
     1921 efelekmesi cqarakeled slqqllrlqd dhrnlrkwlt nqeekwkgme epgektelfc
     1981 qalarkreqf esvaqlnnsl keygfteeee iimeatclmd ryqtllrqls eieeedkllp
     2041 tedqsfndla hdvihwikei keslmvlnss egkmpleeri qkikeiillk pegdarieti
     2101 mkqaesseap lvqktltdis nqwdntlhla stylshqekl llegekylqs kedlrlmlie
     2161 lkkkqeagfa lqhglqekka qlkiykkflk kaqdltsllk elksqgnyll ectknpsfse
     2221 epwleikhlh esllqqlqds vqnldghvre hdsyqvcvtd lnttldnfsk efvsfsdkpv
     2281 dqiaveeklq klqelenrls lqdgtlkkil alaksvkqnt ssvgqkiikd dikslqckqk
     2341 dlenrlasak qemecclnsi lkskrstekk gkftlpgrek qatsdvqest qesaavekle
     2401 edweinkdsa vemamskqls lnaqesmknt ederkvnelq nqpleldtml rneqleeiek
     2461 lytqleakka aikpleqtec lnktetgalv lhnigysaqh ldnllqalit lkknkesqyc
     2521 vlrdfqeyla avessmkall tdkeslkvgp ldsvtyldki kkfiasieke kdslgnlkik
     2581 wenlsnhvtd mdkkllesqi kqlehgweqv eqqiqkkysq qvveydeftt lmnkvqdtei
     2641 slqqqqqhlq lrlkspeera gnqsmialtt dlqatkhgfs vlkgqaelqm kriwgekekk
     2701 nledginnlk kqwetleplh leaenqikkc dirnkmketi lwaknllgel npsipllpdd
     2761 ilsqirkckv thdgilarqq sveslaeevk dkvpslttye gsdlnntled lrnqyqmlvl
     2821 kstqrsqqle fkleersnff aiirkfqlmv qesetliipr vetaateael khhhvtleas
     2881 qkelqeidsg isthlqeltn iyeelnvfer lfledqlknl kirtnriqrf iqntcneveh
     2941 kikfcrqfhe ktsalqeead siqrnellln qevnkgvkee iynlkdrlta ikccilqvlk
     3001 lkkvfdyigl nwdfsqldql qtqvfekeke leekikqldt feeehgkyqa llskmraidl
     3061 qikkmtevvl kapdsspesr rlnaqilsqr iekakclcde iikklnenkt fddsfkekei
     3121 lqiklnaeen dklykvlqnm vlelspkeld ekncqdklet slhvlnqiks qlqqpllinl
     3181 eikhiqnekd nceafqeqvw aemcsikavt aiekqreens seasdvetkl refedlqmql
     3241 ntsidlrtnv lndayenltr ykeavtrave sitsleaiii pyrvdvgnpe eslemplrkq
     3301 eelestvahi qdlteklgmi sspeaklqlq ytlqelvskn samkeafkaq eteaerylen
     3361 ykcyrkmeed iytnlskmet vlgqsmsslp lsyrealerl eqskalvsnl istkeelmkl
     3421 rqilrllrlr ctendgicll kivsalwekw lslleaakew emwceelkqe wkfvseeier
     3481 eaiildnlqe elpeisktke aatteelsel ldclcqygen vekqqllltl llqrirsiqn
     3541 vpessgavet vpafqeitsm kercnkllqk vqknkelvqt eiqerhsftk eiialknffq
     3601 qtttsfqnma fqdhpekseq feelqsilkk gkltfenime klrikysemy tivpaeiesq
     3661 veecrkaled idekisnevl ksspsyamrr kieeinnglh nvekmlqqks kniekaqeiq
     3721 kkmwdeldlw hsklneldse vqdiveqdpg qaqewmdnlm ipfqqyqqvs qraecrtsql
     3781 nkatvkmeey sdllksteaw ientshllan padydslrtl shhastvqma ledseqkhnl
     3841 lhsifmdled lsiifetdel tqsiqelsnq vtalqqkime slpqiqrmad dvvaiesevk
     3901 smekrvskik tillskeifd fspeehlkhg evilenirpm kktiaeivsy qvelrlpqtg
     3961 mkplpvfqrt nqllqdikll envtqeqnel lkvvikqtne wdeeienlkq ilnnysaqfs
     4021 lehmspdqad klpqlqgeie rmekqilsln qrkedllvdl katvlnlhqh lkqeqegver
     4081 drlpavtsee ggvaerdase rklnrrgsms ylaaveeeve essvksdngd ekaepspqsw
     4141 sslwkhdkdm eedrassssg tivqeaygki stsdnsmaqi ltpdslnteq gpecslrpnq
     4201 teegttppie adtldssdaq ggleprvekt rpeptevlha cktqvaelel wlqqanvave
     4261 petlnadmqq vleqqlvgcq amlteiehkv aflletckdq glgdngatqh eaealslklk
     4321 tvkcnlekvq mmlqekhsed qhptilkkss epehqealqp vnlselesiv terpqfsrqk
     4381 dfqqqqvlel kpmeqkdfik fiefnakkmw pqycqhdndt tqessasnqa sspendvpds
     4441 ilspqgqngd kwqylhhels skiklplpql vepqvstnmg ilpsvtmynf ryptteelkt
     4501 yttqledlrq easnlqtqen mteeayinld kklfelfltl sqclssveem lemprlyred
     4561 gsgqqvhyet lalelkklyl alsdkkgdll kamtwpgent nlllecfdnl qvclehtqaa
     4621 avcrskslka gldynrsyqn eikrlyhqli ksktslqqsl neisgqsvae qlqkadaytv
     4681 elenaesrva klrdegerlh lpyallqevy kledvldsmw gmlrarytel sspfvtesqq
     4741 dallqgmvel vkigkeklah ghlkqtkskv alqaqienhk vffqklvadm lliqaysaki
     4801 lpsllqnret fwaeqvtevk ileeksrqcg mklqsllqkw eefdenyasl ekdleilist
     4861 lpsvslveet eerlverisf yqqikrnigg kharlyqtln egkqlvasvs cpelegqiak
     4921 leeqwlslnk kidhelhrlq allkhllsyn rdsdqltkwl essqhtlnyw keqslnvsqd
     4981 ldtirsninn ffefskevde ksslktavis ignqllhlke tdtatlrasl aqfeqkwtml
     5041 itqlpdiqek lhqlqmeklp srkaitemis wmnnvehqts dedsvhspss asqvkhllqk
     5101 hkefrmemdy kqwivdfvnq sllqlstcdv eskryertef aehlgemnrq whrvhgmlnr
     5161 kiqhleqlle sitesenkiq ilnnwleaqe erlktlqkpe svisvqklll dcqdienqla
     5221 ikskaldelk qsyltlesga vplledtasr idelfqkrss vltqvnqlkt smqsvlqewk
     5281 iydqlydevn mmtirfwycm ehskpvvlsl etlrcqvenl qslqdeaess egsweklqev
     5341 igklkglcps vaeiieekcq nthkrwtqvn qaiadqlqka qsllqlwkay snahgeaaar
     5401 lkqqeakfqq lanismsgnn laeilppalq dikelqhdvq ktkeaflqns svldrlpqpa
     5461 essthmllpg plhslqraay lekmllvkan efefvlsqfk dfgvrleslk glimheeenl
     5521 drlhqqeken pdsflnhvla ltaqspdieh lnevslklpl sdvavktlqn mnrqwirata
     5581 talercselq giglnekfly ccekwiqlle kieealkvdv anslpelleq qktykmleae
     5641 vsinqtiads yvtqslqlld tteienrpef itefskltdr wqnavqgvrq rkgdvdglvr
     5701 qwqdfttsve nlfrfltdts hllsavkgqe rfslyqtrsl ihelknkeih fqrrrttcal
     5761 tleageklll ttdlktkesv grrisqlqds wkdmepqlae mikqfqstve twdqcekkik
     5821 elksrlqvlk aqsedplpel hedlhnekel ikeleqslas wtqnlkelqt mkadltrhvl
     5881 vedvmvlkeq iehlhrqwed lclrvairkq eiedrlntwv vfneknkelc awlvqmenkv
     5941 lqtadisiee mieklqkdcm eeinlfsenk lqlkqmgdql ikasnksraa eiddklnkin
     6001 drwqhlfdvi gsrvkklket fafiqqldkn msnlrtwlar ieselskpvv ydvcddqeiq
     6061 krlaeqqdlq rdieqhsagv esvfnicdvl lhdsdacane tecdsiqqtt rsldrrwrni
     6121 camsmerrmk ieetwrlwqk flddysrfed wlksaertaa cpnssevlyt sakeelkrfe
     6181 afqrqiherl tqlelinkqy rrlarenrtd tasrlkqmvh egnqrwdnlq rrvtavlrrl
     6241 rhftnqreef egtresilvw ltemdlqltn vehfsesdad dkmrqlngfq qeitlntnki
     6301 dqlivfgeql iqksepldav liedeleelh rycqevfgrv srfhrrltsc tpgledekea
     6361 senetdmedp reiqtdswrk rgeseepssp qslchlvapg hersgcetpv svdsiplewd
     6421 htgdvggsss heedeegpyy salsgksisd ghswhvpdsp scpehhykqm egdrnvppvp
     6481 passtpykpp ygklllppgt dggkegprvl ngnpqqedgg lagiteqqsg afdrwemiqa
     6541 qelhnklkik qnlqqlnsdi saittwlkkt eaelemlkma kppsdiqeie lrvkrlqeil
     6601 kafdtykalv vsvnvsskef lqtespeste lqsrlrqlsl lweaaqgavd swrgglrqsl
     6661 mqcqdfhqls qnlllwlasa knrrqkahvt dpkadprall ecrrelmqle kelverqpqv
     6721 dmlqeisnsl likghgedci eaeekvhvie kklkqlreqv sqdlmalqgt qnpasplpsf
     6781 devdsgdqpp atsvpaprak fravrttege eetesrvpgs trpqrsflsr vvraalplql
     6841 llllllllac llpsseedys ctqannfars fypmlrytng pppt
//
LOCUS       XP_047287113            6868 aa            linear   PRI 05-AUG-2025
DEFINITION  nesprin-2 isoform X16 [Homo sapiens].
ACCESSION   XP_047287113
VERSION     XP_047287113.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431157.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..6868
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..6868
                     /product="nesprin-2 isoform X16"
                     /calculated_mol_wt=794498
     Region          28..138
                     /region_name="CH_SYNE2_rpt1"
                     /note="first calponin homology (CH) domain found in
                     synaptic nuclear envelope protein 2; cd21242"
                     /db_xref="CDD:409091"
     Site            order(33,37,89,91..92,95..96,98,107..115,120,122..123,
                     125..126,129..130,133)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409091"
     Region          178..286
                     /region_name="CH_SYNE2_rpt2"
                     /note="second calponin homology (CH) domain found in
                     synaptic nuclear envelope protein 2 (SYNE-2) and similar
                     proteins; cd21244"
                     /db_xref="CDD:409093"
     Site            order(183,187,237,239..240,243..244,246,255..263,270,
                     272..273,275..276,279..280,283)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409093"
     Region          <1418..2014
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          <1868..>2369
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          <2338..2712
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          2805..>3389
                     /region_name="CCDC158"
                     /note="Coiled-coil domain-containing protein 158;
                     pfam15921"
                     /db_xref="CDD:464943"
     Region          <3656..>3950
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <3811..4113
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <4457..5282
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          4906..5130
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            5015..5020
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5024..5237
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Region          5084..>5836
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Site            5129..5134
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5139..5345
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cl02488"
                     /db_xref="CDD:413338"
     Site            5236..5241
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5880..6094
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            5981..5986
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          6098..6311
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6204..6209
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          6537..6746
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6643..6648
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          <6837..6868
                     /region_name="KASH"
                     /note="Nuclear envelope localization domain; pfam10541"
                     /db_xref="CDD:463142"
     CDS             1..6868
                     /gene="SYNE2"
                     /gene_synonym="EDMD5; KASH2; Nesp2; Nesprin-2; NUA;
                     NUANCE; SYNE-2; TROPH"
                     /coded_by="XM_047431157.1:192..20798"
                     /db_xref="GeneID:23224"
                     /db_xref="HGNC:HGNC:17084"
                     /db_xref="MIM:608442"
ORIGIN      
        1 masspelpte deqgswgidd lhislqaeqe dtqkkaftcw insqlarhts psvisdlftd
       61 ikkghvlldl levlsgqqlp rdkgsntfqc riniehaltf lrnrsiklin ihvtdiidgn
      121 psiilgliwt iilhfhiekl aqtlscnynq pslddvsvvd sspassppak kcskvqarwq
      181 msarkalllw aqeqcatyes vnvtdfkssw rngmaflaii halrpdlidm ksvkhrsnkd
      241 nlreafriae qelkiprlle pedvdvvdpd eksimtyvaq flqyskdapg tgeeaqgkvk
      301 damgwltlqk eklqkllkds endtyfkkyn sllsfmesfn eekksfldvl sikrdldeld
      361 kdhlqlreaw dgldhqinaw kiklnyalpp plhqteawlq eveelmdedl sasqdhsqav
      421 tliqekmtlf kslmdrfehh snilltfenk denhlplvpp nkleemkrri nnilekkfil
      481 llefhyykcl vlglvdevks kldiwnikyg sresvellle dwhkfieeke flarldtsfq
      541 kcgeiyknla gecqninkqy mmvksdvcmy rkniynvkst lqkvlacwat yvenlrllra
      601 cfeetkkeei kevpfetlaq wnlehatlne agnflvevsn dvvgssiske lrrlnkrwrk
      661 lvsktqlemn lplmikkqdq ptfdnsgnil skeekatvef stdmsvelpe nynqnikage
      721 khekeneeft gqlkvakdve kligqveiwe aeaksvldqd dvdtsmeesl khliakgsmf
      781 delmarsedm lqmdiqniss qesfqhvltt glqakiqeak ekvqinvvkl iaalknltdv
      841 spdldirlkm eesqkelesy mmraqqllgq respgelisk hkealiisnt kslakylkav
      901 eelknnvted ikmsleeksr dvcakweslh helslyvqql kidiekgkls dnilklekqi
      961 nkekklirrg rtkglikehe acfseegcly qlnhhmevlr elceelpsqk sqqevkrllk
     1021 dyeqkierll kcaseihmtl qptaggtskn egtittsenr ggdphseapf aksdnqpste
     1081 kameptmkfs lasvlrplqe esimekdysa sinslleryd tyrdilehhl qnnkfritsd
     1141 fsseedrsss clqakltdlq viknetdarw kefeiislkl enhvndikkp fvikerdtlk
     1201 ererelqmtl ntrmesleta lrlvlpveka slllcgsdlp lhkmaiqgfh lidadriyqh
     1261 lrniqdsiak qieicnrlee pgnfvlkelh pfdlhamqni ilkyktqfeg mnhrvqrsed
     1321 tlkaledfla slrtaklsae pvtdlsasdt qvaqentltv knkegeihlm kdkakhldkc
     1381 lkmldmsfkd aergddtsce nlldafsikl sethgygvqe efteenklle acifknnell
     1441 kniqdvqsqi skiglkdptv pavkhrkksl irldkvldey eeekrhlqem anslphfkdg
     1501 rektvnqqcq ntvvlwentk alvtecleqc grvlellkqy qnfksilttl iqkeesvisl
     1561 qasymgkenl kkriaeieiv keefnehlev vdkinqvckn lqfylnkmkt feeppfekea
     1621 niivdrwldi nektedyyen lgralalwdk lfnlknvide wtekalqkme lhqlteedre
     1681 rlkeelqvhe qktsefsrrv aeiqfllqss eiplelqvme ssilnkmehv qkcltgesnc
     1741 halsgstael redldqaktq igmtesllka lspsdsleif tkleeiqqqi lqqkhsmill
     1801 enqigcltpe lselkkqyes vsdlfntkks vlqdhfskll ndqcknfndw fsnikvnlke
     1861 cfessetkks veqklqklsd fltlegrnsk ikqvdsvlkh vkkhlpkahv keliswlvgq
     1921 efelekmesi cqarakeled slqqllrlqd dhrnlrkwlt nqeekwkgme epgektelfc
     1981 qalarkreqf esvaqlnnsl keygfteeee iimeatclmd ryqtllrqls eieeedkllp
     2041 tedqsfndla hdvihwikei keslmvlnss egkmpleeri qkikeiillk pegdarieti
     2101 mkqaesseap lvqktltdis nqwdntlhla stylshqekl llegekylqs kedlrlmlie
     2161 lkkkqeagfa lqhglqekka qlkiykkflk kaqdltsllk elksqgnyll ectknpsfse
     2221 epwleikhlh esllqqlqds vqnldghvre hdsyqvcvtd lnttldnfsk efvsfsdkpv
     2281 dqiaveeklq klqelenrls lqdgtlkkil alaksvkqnt ssvgqkiikd dikslqckqk
     2341 dlenrlasak qemecclnsi lkskrstekk gkftlpgrek qatsdvqest qesaavekle
     2401 edweinkdsa vemamskqls lnaqesmknt ederkvnelq nqpleldtml rneqleeiek
     2461 lytqleakka aikpleqtec lnktetgalv lhnigysaqh ldnllqalit lkknkesqyc
     2521 vlrdfqeyla avessmkall tdkeslkvgp ldsvtyldki kkfiasieke kdslgnlkik
     2581 wenlsnhvtd mdkkllesqi kqlehgweqv eqqiqkkysq qvveydeftt lmnkvqdtei
     2641 slqqqqqhlq lrlkspeera gnqsmialtt dlqatkhgfs vlkgqaelqm kriwgekekk
     2701 nledginnlk kqwetleplh leaenqikkc dirnkmketi lwaknllgel npsipllpdd
     2761 ilsqirkckv thdgilarqq sveslaeevk dkvpslttye gsdlnntled lrnqyqmlvl
     2821 kstqrsqqle fkleersnff aiirkfqlmv qesetliipr vetaateael khhhvtleas
     2881 qkelqeidsg isthlqeltn iyeelnvfer lfledqlknl kirtnriqrf iqntcneveh
     2941 kikfcrqfhe ktsalqeead siqrnellln qevnkgvkee iynlkdrlta ikccilqvlk
     3001 lkkvfdyigl nwdfsqldql qtqvfekeke leekikqldt feeehgkyqa llskmraidl
     3061 qikkmtevvl kapdsspesr rlnaqilsqr iekakclcde iikklnenkt fddsfkekei
     3121 lqiklnaeen dklykvlqnm vlelspkeld ekncqdklet slhvlnqiks qlqqpllinl
     3181 eikhiqnekd nceafqeqvw aemcsikavt aiekqreens seasdvetkl refedlqmql
     3241 ntsidlrtnv lndayenltr ykeavtrave sitsleaiii pyrvdvgnpe eslemplrkq
     3301 eelestvahi qdlteklgmi sspeaklqlq ytlqelvskn samkeafkaq eteaerylen
     3361 ykcyrkmeed iytnlskmet vlgqsmsslp lsyrealerl eqskalvsnl istkeelmkl
     3421 rqilrllrlr ctendgicll kivsalwekw lslleaakew emwceelkqe wkfvseeier
     3481 eaiildnlqe elpeisktke aatteelsel ldclcqygen vekqqllltl llqrirsiqn
     3541 vpessgavet vpafqeitsm kercnkllqk vqknkelvqt eiqerhsftk eiialknffq
     3601 qtttsfqnma fqdhpekseq feelqsilkk gkltfenime klrikysemy tivpaeiesq
     3661 veecrkaled idekisnevl ksspsyamrr kieeinnglh nvekmlqqks kniekaqeiq
     3721 kkmwdeldlw hsklneldse vqdiveqdpg qaqewmdnlm ipfqqyqqvs qraecrtsql
     3781 nkatvkmeey sdllksteaw ientshllan padydslrtl shhastvqma ledseqkhnl
     3841 lhsifmdled lsiifetdel tqsiqelsnq vtalqqkime slpqiqrmad dvvaiesevk
     3901 smekrvskik tillskeifd fspeehlkhg evilenirpm kktiaeivsy qvelrlpqtg
     3961 mkplpvfqrt nqllqdikll envtqeqnel lkvvikqtne wdeeienlkq ilnnysaqfs
     4021 lehmspdqad klpqlqgeie rmekqilsln qrkedllvdl katvlnlhqh lkqeqegver
     4081 drlpavtsee ggvaerdase rklnrrgsms ylaaveeeve essvksdngd ekaepspqsw
     4141 sslwkhdkdm eedrassssg tivqgttppi eadtldssda qggleprvek trpeptevlh
     4201 acktqvaele lwlqqanvav epetlnadmq qvleqqlvgc qamlteiehk vaflletckd
     4261 qglgdngatq heaealslkl ktvkcnlekv qmmlqekhse dqhptilkks sepehqealq
     4321 pvnlselesi vterpqfsrq kdfqqqqvle lkpmeqkdfi kfiefnakkm wpqycqhdnd
     4381 ttqessasnq asspendvpd silspqgqng dkwqylhhel sskiklplpq lvepqvstnm
     4441 gilpsvtmyn fryptteelk tyttqledlr qeasnlqtqe nmteeayinl dkklfelflt
     4501 lsqclssvee mlemprlyre dgsgqqvhye tlalelkkly lalsdkkgdl lkamtwpgen
     4561 tnlllecfdn lqvclehtqa aavcrskslk agldynrsyq neikrlyhql iksktslqqs
     4621 lneisgqsva eqlqkadayt velenaesrv aklrdegerl hlpyallqev ykledvldsm
     4681 wgmlraryte lsspfvtesq qdallqgmve lvkigkekla hghlkqtksk valqaqienh
     4741 kvffqklvad mlliqaysak ilpsllqnre tfwaeqvtev kileeksrqc gmklqsllqk
     4801 weefdenyas lekdleilis tlpsvslvee teerlveris fyqqikrnig gkharlyqtl
     4861 negkqlvasv scpelegqia kleeqwlsln kkidhelhrl qallkhllsy nrdsdqltkw
     4921 lessqhtlny wkeqslnvsq dldtirsnin nffefskevd eksslktavi signqllhlk
     4981 etdtatlras laqfeqkwtm litqlpdiqe klhqlqmekl psrkaitemi swmnnvehqt
     5041 sdedsvhsps sasqvkhllq khkefrmemd ykqwivdfvn qsllqlstcd veskryerte
     5101 faehlgemnr qwhrvhgmln rkiqhleqll esitesenki qilnnwleaq eerlktlqkp
     5161 esvisvqkll ldcqdienql aikskaldel kqsyltlesg avplledtas ridelfqkrs
     5221 svltqvnqlk tsmqsvlqew kiydqlydev nmmtirfwyc mehskpvvls letlrcqven
     5281 lqslqdeaes segsweklqe vigklkglcp svaeiieekc qnthkrwtqv nqaiadqlqk
     5341 aqsllqlwka ysnahgeaaa rlkqqeakfq qlanismsgn nlaeilppal qdikelqhdv
     5401 qktkeaflqn ssvldrlpqp aessthmllp gplhslqraa ylekmllvka nefefvlsqf
     5461 kdfgvrlesl kglimheeen ldrlhqqeke npdsflnhvl altaqspdie hlnevslklp
     5521 lsdvavktlq nmnrqwirat atalercsel qgiglnekfl yccekwiqll ekieealkvd
     5581 vanslpelle qqktykmlea evsinqtiad syvtqslqll dtteienrpe fitefskltd
     5641 rwqnavqgvr qrkgdvdglv rqwqdfttsv enlfrfltdt shllsavkgq erfslyqtrs
     5701 lihelknkei hfqrrrttca ltleagekll lttdlktkes vgrrisqlqd swkdmepqla
     5761 emikqfqstv etwdqcekki kelksrlqvl kaqsedplpe lhedlhneke likeleqsla
     5821 swtqnlkelq tmkadltrhv lvedvmvlke qiehlhrqwe dlclrvairk qeiedrlntw
     5881 vvfneknkel cawlvqmenk vlqtadisie emieklqkdc meeinlfsen klqlkqmgdq
     5941 likasnksra aeiddklnki ndrwqhlfdv igsrvkklke tfafiqqldk nmsnlrtwla
     6001 rieselskpv vydvcddqei qkrlaeqqdl qrdieqhsag vesvfnicdv llhdsdacan
     6061 etecdsiqqt trsldrrwrn icamsmerrm kieetwrlwq kflddysrfe dwlksaerta
     6121 acpnssevly tsakeelkrf eafqrqiher ltqlelinkq yrrlarenrt dtasrlkqmv
     6181 hegnqrwdnl qrrvtavlrr lrhftnqree fegtresilv wltemdlqlt nvehfsesda
     6241 ddkmrqlngf qqeitlntnk idqlivfgeq liqkseplda vliedeleel hrycqevfgr
     6301 vsrfhrrlts ctpgledeke asenetdmed preiqtdswr krgeseepss pqslchlvap
     6361 ghersgcetp vsvdsiplew dhtgdvggss sheedeegpy ysalsdveip enpeaylkmt
     6421 tktlkassgk sisdghswhv pdspscpehh ykqmegdrnv ppvppasstp ykppygklll
     6481 ppgtdggkeg prvlngnpqq edgglagite qqsgafdrwe miqaqelhnk lkikqnlqql
     6541 nsdisaittw lkkteaelem lkmakppsdi qeielrvkrl qeilkafdty kalvvsvnvs
     6601 skeflqtesp estelqsrlr qlsllweaaq gavdswrggl rqslmqcqdf hqlsqnlllw
     6661 lasaknrrqk ahvtdpkadp rallecrrel mqlekelver qpqvdmlqei snsllikghg
     6721 edcieaeekv hviekklkql reqvsqdlma lqgtqnpasp lpsfdevdsg dqppatsvpa
     6781 prakfravrt tegeeetesr vpgstrpqrs flsrvvraal plqlllllll llacllpsse
     6841 edysctqann farsfypmlr ytngpppt
//
LOCUS       XP_047287114            6846 aa            linear   PRI 05-AUG-2025
DEFINITION  nesprin-2 isoform X17 [Homo sapiens].
ACCESSION   XP_047287114
VERSION     XP_047287114.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431158.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..6846
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..6846
                     /product="nesprin-2 isoform X17"
                     /calculated_mol_wt=792078
     Region          28..138
                     /region_name="CH_SYNE2_rpt1"
                     /note="first calponin homology (CH) domain found in
                     synaptic nuclear envelope protein 2; cd21242"
                     /db_xref="CDD:409091"
     Site            order(33,37,89,91..92,95..96,98,107..115,120,122..123,
                     125..126,129..130,133)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409091"
     Region          178..286
                     /region_name="CH_SYNE2_rpt2"
                     /note="second calponin homology (CH) domain found in
                     synaptic nuclear envelope protein 2 (SYNE-2) and similar
                     proteins; cd21244"
                     /db_xref="CDD:409093"
     Site            order(183,187,237,239..240,243..244,246,255..263,270,
                     272..273,275..276,279..280,283)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409093"
     Region          <1418..2014
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          <1868..>2369
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          <2338..2712
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          2805..>3389
                     /region_name="CCDC158"
                     /note="Coiled-coil domain-containing protein 158;
                     pfam15921"
                     /db_xref="CDD:464943"
     Region          <3656..>3950
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <3811..4113
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <4457..5282
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          4906..5130
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            5015..5020
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5024..5237
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Region          5084..>5836
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Site            5129..5134
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5139..5345
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cl02488"
                     /db_xref="CDD:413338"
     Site            5236..5241
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          5880..6094
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            5981..5986
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          6098..6311
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6204..6209
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          6514..6723
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            6620..6625
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          <6815..6846
                     /region_name="KASH"
                     /note="Nuclear envelope localization domain; pfam10541"
                     /db_xref="CDD:463142"
     CDS             1..6846
                     /gene="SYNE2"
                     /gene_synonym="EDMD5; KASH2; Nesp2; Nesprin-2; NUA;
                     NUANCE; SYNE-2; TROPH"
                     /coded_by="XM_047431158.1:192..20732"
                     /db_xref="GeneID:23224"
                     /db_xref="HGNC:HGNC:17084"
                     /db_xref="MIM:608442"
ORIGIN      
        1 masspelpte deqgswgidd lhislqaeqe dtqkkaftcw insqlarhts psvisdlftd
       61 ikkghvlldl levlsgqqlp rdkgsntfqc riniehaltf lrnrsiklin ihvtdiidgn
      121 psiilgliwt iilhfhiekl aqtlscnynq pslddvsvvd sspassppak kcskvqarwq
      181 msarkalllw aqeqcatyes vnvtdfkssw rngmaflaii halrpdlidm ksvkhrsnkd
      241 nlreafriae qelkiprlle pedvdvvdpd eksimtyvaq flqyskdapg tgeeaqgkvk
      301 damgwltlqk eklqkllkds endtyfkkyn sllsfmesfn eekksfldvl sikrdldeld
      361 kdhlqlreaw dgldhqinaw kiklnyalpp plhqteawlq eveelmdedl sasqdhsqav
      421 tliqekmtlf kslmdrfehh snilltfenk denhlplvpp nkleemkrri nnilekkfil
      481 llefhyykcl vlglvdevks kldiwnikyg sresvellle dwhkfieeke flarldtsfq
      541 kcgeiyknla gecqninkqy mmvksdvcmy rkniynvkst lqkvlacwat yvenlrllra
      601 cfeetkkeei kevpfetlaq wnlehatlne agnflvevsn dvvgssiske lrrlnkrwrk
      661 lvsktqlemn lplmikkqdq ptfdnsgnil skeekatvef stdmsvelpe nynqnikage
      721 khekeneeft gqlkvakdve kligqveiwe aeaksvldqd dvdtsmeesl khliakgsmf
      781 delmarsedm lqmdiqniss qesfqhvltt glqakiqeak ekvqinvvkl iaalknltdv
      841 spdldirlkm eesqkelesy mmraqqllgq respgelisk hkealiisnt kslakylkav
      901 eelknnvted ikmsleeksr dvcakweslh helslyvqql kidiekgkls dnilklekqi
      961 nkekklirrg rtkglikehe acfseegcly qlnhhmevlr elceelpsqk sqqevkrllk
     1021 dyeqkierll kcaseihmtl qptaggtskn egtittsenr ggdphseapf aksdnqpste
     1081 kameptmkfs lasvlrplqe esimekdysa sinslleryd tyrdilehhl qnnkfritsd
     1141 fsseedrsss clqakltdlq viknetdarw kefeiislkl enhvndikkp fvikerdtlk
     1201 ererelqmtl ntrmesleta lrlvlpveka slllcgsdlp lhkmaiqgfh lidadriyqh
     1261 lrniqdsiak qieicnrlee pgnfvlkelh pfdlhamqni ilkyktqfeg mnhrvqrsed
     1321 tlkaledfla slrtaklsae pvtdlsasdt qvaqentltv knkegeihlm kdkakhldkc
     1381 lkmldmsfkd aergddtsce nlldafsikl sethgygvqe efteenklle acifknnell
     1441 kniqdvqsqi skiglkdptv pavkhrkksl irldkvldey eeekrhlqem anslphfkdg
     1501 rektvnqqcq ntvvlwentk alvtecleqc grvlellkqy qnfksilttl iqkeesvisl
     1561 qasymgkenl kkriaeieiv keefnehlev vdkinqvckn lqfylnkmkt feeppfekea
     1621 niivdrwldi nektedyyen lgralalwdk lfnlknvide wtekalqkme lhqlteedre
     1681 rlkeelqvhe qktsefsrrv aeiqfllqss eiplelqvme ssilnkmehv qkcltgesnc
     1741 halsgstael redldqaktq igmtesllka lspsdsleif tkleeiqqqi lqqkhsmill
     1801 enqigcltpe lselkkqyes vsdlfntkks vlqdhfskll ndqcknfndw fsnikvnlke
     1861 cfessetkks veqklqklsd fltlegrnsk ikqvdsvlkh vkkhlpkahv keliswlvgq
     1921 efelekmesi cqarakeled slqqllrlqd dhrnlrkwlt nqeekwkgme epgektelfc
     1981 qalarkreqf esvaqlnnsl keygfteeee iimeatclmd ryqtllrqls eieeedkllp
     2041 tedqsfndla hdvihwikei keslmvlnss egkmpleeri qkikeiillk pegdarieti
     2101 mkqaesseap lvqktltdis nqwdntlhla stylshqekl llegekylqs kedlrlmlie
     2161 lkkkqeagfa lqhglqekka qlkiykkflk kaqdltsllk elksqgnyll ectknpsfse
     2221 epwleikhlh esllqqlqds vqnldghvre hdsyqvcvtd lnttldnfsk efvsfsdkpv
     2281 dqiaveeklq klqelenrls lqdgtlkkil alaksvkqnt ssvgqkiikd dikslqckqk
     2341 dlenrlasak qemecclnsi lkskrstekk gkftlpgrek qatsdvqest qesaavekle
     2401 edweinkdsa vemamskqls lnaqesmknt ederkvnelq nqpleldtml rneqleeiek
     2461 lytqleakka aikpleqtec lnktetgalv lhnigysaqh ldnllqalit lkknkesqyc
     2521 vlrdfqeyla avessmkall tdkeslkvgp ldsvtyldki kkfiasieke kdslgnlkik
     2581 wenlsnhvtd mdkkllesqi kqlehgweqv eqqiqkkysq qvveydeftt lmnkvqdtei
     2641 slqqqqqhlq lrlkspeera gnqsmialtt dlqatkhgfs vlkgqaelqm kriwgekekk
     2701 nledginnlk kqwetleplh leaenqikkc dirnkmketi lwaknllgel npsipllpdd
     2761 ilsqirkckv thdgilarqq sveslaeevk dkvpslttye gsdlnntled lrnqyqmlvl
     2821 kstqrsqqle fkleersnff aiirkfqlmv qesetliipr vetaateael khhhvtleas
     2881 qkelqeidsg isthlqeltn iyeelnvfer lfledqlknl kirtnriqrf iqntcneveh
     2941 kikfcrqfhe ktsalqeead siqrnellln qevnkgvkee iynlkdrlta ikccilqvlk
     3001 lkkvfdyigl nwdfsqldql qtqvfekeke leekikqldt feeehgkyqa llskmraidl
     3061 qikkmtevvl kapdsspesr rlnaqilsqr iekakclcde iikklnenkt fddsfkekei
     3121 lqiklnaeen dklykvlqnm vlelspkeld ekncqdklet slhvlnqiks qlqqpllinl
     3181 eikhiqnekd nceafqeqvw aemcsikavt aiekqreens seasdvetkl refedlqmql
     3241 ntsidlrtnv lndayenltr ykeavtrave sitsleaiii pyrvdvgnpe eslemplrkq
     3301 eelestvahi qdlteklgmi sspeaklqlq ytlqelvskn samkeafkaq eteaerylen
     3361 ykcyrkmeed iytnlskmet vlgqsmsslp lsyrealerl eqskalvsnl istkeelmkl
     3421 rqilrllrlr ctendgicll kivsalwekw lslleaakew emwceelkqe wkfvseeier
     3481 eaiildnlqe elpeisktke aatteelsel ldclcqygen vekqqllltl llqrirsiqn
     3541 vpessgavet vpafqeitsm kercnkllqk vqknkelvqt eiqerhsftk eiialknffq
     3601 qtttsfqnma fqdhpekseq feelqsilkk gkltfenime klrikysemy tivpaeiesq
     3661 veecrkaled idekisnevl ksspsyamrr kieeinnglh nvekmlqqks kniekaqeiq
     3721 kkmwdeldlw hsklneldse vqdiveqdpg qaqewmdnlm ipfqqyqqvs qraecrtsql
     3781 nkatvkmeey sdllksteaw ientshllan padydslrtl shhastvqma ledseqkhnl
     3841 lhsifmdled lsiifetdel tqsiqelsnq vtalqqkime slpqiqrmad dvvaiesevk
     3901 smekrvskik tillskeifd fspeehlkhg evilenirpm kktiaeivsy qvelrlpqtg
     3961 mkplpvfqrt nqllqdikll envtqeqnel lkvvikqtne wdeeienlkq ilnnysaqfs
     4021 lehmspdqad klpqlqgeie rmekqilsln qrkedllvdl katvlnlhqh lkqeqegver
     4081 drlpavtsee ggvaerdase rklnrrgsms ylaaveeeve essvksdngd ekaepspqsw
     4141 sslwkhdkdm eedrassssg tivqgttppi eadtldssda qggleprvek trpeptevlh
     4201 acktqvaele lwlqqanvav epetlnadmq qvleqqlvgc qamlteiehk vaflletckd
     4261 qglgdngatq heaealslkl ktvkcnlekv qmmlqekhse dqhptilkks sepehqealq
     4321 pvnlselesi vterpqfsrq kdfqqqqvle lkpmeqkdfi kfiefnakkm wpqycqhdnd
     4381 ttqessasnq asspendvpd silspqgqng dkwqylhhel sskiklplpq lvepqvstnm
     4441 gilpsvtmyn fryptteelk tyttqledlr qeasnlqtqe nmteeayinl dkklfelflt
     4501 lsqclssvee mlemprlyre dgsgqqvhye tlalelkkly lalsdkkgdl lkamtwpgen
     4561 tnlllecfdn lqvclehtqa aavcrskslk agldynrsyq neikrlyhql iksktslqqs
     4621 lneisgqsva eqlqkadayt velenaesrv aklrdegerl hlpyallqev ykledvldsm
     4681 wgmlraryte lsspfvtesq qdallqgmve lvkigkekla hghlkqtksk valqaqienh
     4741 kvffqklvad mlliqaysak ilpsllqnre tfwaeqvtev kileeksrqc gmklqsllqk
     4801 weefdenyas lekdleilis tlpsvslvee teerlveris fyqqikrnig gkharlyqtl
     4861 negkqlvasv scpelegqia kleeqwlsln kkidhelhrl qallkhllsy nrdsdqltkw
     4921 lessqhtlny wkeqslnvsq dldtirsnin nffefskevd eksslktavi signqllhlk
     4981 etdtatlras laqfeqkwtm litqlpdiqe klhqlqmekl psrkaitemi swmnnvehqt
     5041 sdedsvhsps sasqvkhllq khkefrmemd ykqwivdfvn qsllqlstcd veskryerte
     5101 faehlgemnr qwhrvhgmln rkiqhleqll esitesenki qilnnwleaq eerlktlqkp
     5161 esvisvqkll ldcqdienql aikskaldel kqsyltlesg avplledtas ridelfqkrs
     5221 svltqvnqlk tsmqsvlqew kiydqlydev nmmtirfwyc mehskpvvls letlrcqven
     5281 lqslqdeaes segsweklqe vigklkglcp svaeiieekc qnthkrwtqv nqaiadqlqk
     5341 aqsllqlwka ysnahgeaaa rlkqqeakfq qlanismsgn nlaeilppal qdikelqhdv
     5401 qktkeaflqn ssvldrlpqp aessthmllp gplhslqraa ylekmllvka nefefvlsqf
     5461 kdfgvrlesl kglimheeen ldrlhqqeke npdsflnhvl altaqspdie hlnevslklp
     5521 lsdvavktlq nmnrqwirat atalercsel qgiglnekfl yccekwiqll ekieealkvd
     5581 vanslpelle qqktykmlea evsinqtiad syvtqslqll dtteienrpe fitefskltd
     5641 rwqnavqgvr qrkgdvdglv rqwqdfttsv enlfrfltdt shllsavkgq erfslyqtrs
     5701 lihelknkei hfqrrrttca ltleagekll lttdlktkes vgrrisqlqd swkdmepqla
     5761 emikqfqstv etwdqcekki kelksrlqvl kaqsedplpe lhedlhneke likeleqsla
     5821 swtqnlkelq tmkadltrhv lvedvmvlke qiehlhrqwe dlclrvairk qeiedrlntw
     5881 vvfneknkel cawlvqmenk vlqtadisie emieklqkdc meeinlfsen klqlkqmgdq
     5941 likasnksra aeiddklnki ndrwqhlfdv igsrvkklke tfafiqqldk nmsnlrtwla
     6001 rieselskpv vydvcddqei qkrlaeqqdl qrdieqhsag vesvfnicdv llhdsdacan
     6061 etecdsiqqt trsldrrwrn icamsmerrm kieetwrlwq kflddysrfe dwlksaerta
     6121 acpnssevly tsakeelkrf eafqrqiher ltqlelinkq yrrlarenrt dtasrlkqmv
     6181 hegnqrwdnl qrrvtavlrr lrhftnqree fegtresilv wltemdlqlt nvehfsesda
     6241 ddkmrqlngf qqeitlntnk idqlivfgeq liqkseplda vliedeleel hrycqevfgr
     6301 vsrfhrrlts ctpgledeke asenetdmed preiqtdswr krgeseepss pqslchlvap
     6361 ghersgcetp vsvdsiplew dhtgdvggss sheedeegpy ysalsgksis dghswhvpds
     6421 pscpehhykq megdrnvppv ppasstpykp pygklllppg tdggkegprv lngnpqqedg
     6481 glagiteqqs gafdrwemiq aqelhnklki kqnlqqlnsd isaittwlkk teaelemlkm
     6541 akppsdiqei elrvkrlqei lkafdtykal vvsvnvsske flqtespest elqsrlrqls
     6601 llweaaqgav dswrgglrqs lmqcqdfhql sqnlllwlas aknrrqkahv tdpkadpral
     6661 lecrrelmql ekelverqpq vdmlqeisns llikghgedc ieaeekvhvi ekklkqlreq
     6721 vsqdlmalqg tqnpasplps fdevdsgdqp patsvpapra kqfravrtte geeetesrvp
     6781 gstrpqrsfl srvvraalpl qlllllllll acllpsseed ysctqannfa rsfypmlryt
     6841 ngpppt
//
LOCUS       XP_047287115            4788 aa            linear   PRI 05-AUG-2025
DEFINITION  nesprin-2 isoform X18 [Homo sapiens].
ACCESSION   XP_047287115
VERSION     XP_047287115.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431159.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4788
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..4788
                     /product="nesprin-2 isoform X18"
                     /calculated_mol_wt=553476
     Region          28..138
                     /region_name="CH_SYNE2_rpt1"
                     /note="first calponin homology (CH) domain found in
                     synaptic nuclear envelope protein 2; cd21242"
                     /db_xref="CDD:409091"
     Site            order(33,37,89,91..92,95..96,98,107..115,120,122..123,
                     125..126,129..130,133)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409091"
     Region          178..286
                     /region_name="CH_SYNE2_rpt2"
                     /note="second calponin homology (CH) domain found in
                     synaptic nuclear envelope protein 2 (SYNE-2) and similar
                     proteins; cd21244"
                     /db_xref="CDD:409093"
     Site            order(183,187,237,239..240,243..244,246,255..263,270,
                     272..273,275..276,279..280,283)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409093"
     Region          <1418..2014
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          <1868..>2369
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          <2338..2712
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          2805..>3389
                     /region_name="CCDC158"
                     /note="Coiled-coil domain-containing protein 158;
                     pfam15921"
                     /db_xref="CDD:464943"
     Region          <3656..>3950
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <3811..4113
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     CDS             1..4788
                     /gene="SYNE2"
                     /gene_synonym="EDMD5; KASH2; Nesp2; Nesprin-2; NUA;
                     NUANCE; SYNE-2; TROPH"
                     /coded_by="XM_047431159.1:192..14558"
                     /db_xref="GeneID:23224"
                     /db_xref="HGNC:HGNC:17084"
                     /db_xref="MIM:608442"
ORIGIN      
        1 masspelpte deqgswgidd lhislqaeqe dtqkkaftcw insqlarhts psvisdlftd
       61 ikkghvlldl levlsgqqlp rdkgsntfqc riniehaltf lrnrsiklin ihvtdiidgn
      121 psiilgliwt iilhfhiekl aqtlscnynq pslddvsvvd sspassppak kcskvqarwq
      181 msarkalllw aqeqcatyes vnvtdfkssw rngmaflaii halrpdlidm ksvkhrsnkd
      241 nlreafriae qelkiprlle pedvdvvdpd eksimtyvaq flqyskdapg tgeeaqgkvk
      301 damgwltlqk eklqkllkds endtyfkkyn sllsfmesfn eekksfldvl sikrdldeld
      361 kdhlqlreaw dgldhqinaw kiklnyalpp plhqteawlq eveelmdedl sasqdhsqav
      421 tliqekmtlf kslmdrfehh snilltfenk denhlplvpp nkleemkrri nnilekkfil
      481 llefhyykcl vlglvdevks kldiwnikyg sresvellle dwhkfieeke flarldtsfq
      541 kcgeiyknla gecqninkqy mmvksdvcmy rkniynvkst lqkvlacwat yvenlrllra
      601 cfeetkkeei kevpfetlaq wnlehatlne agnflvevsn dvvgssiske lrrlnkrwrk
      661 lvsktqlemn lplmikkqdq ptfdnsgnil skeekatvef stdmsvelpe nynqnikage
      721 khekeneeft gqlkvakdve kligqveiwe aeaksvldqd dvdtsmeesl khliakgsmf
      781 delmarsedm lqmdiqniss qesfqhvltt glqakiqeak ekvqinvvkl iaalknltdv
      841 spdldirlkm eesqkelesy mmraqqllgq respgelisk hkealiisnt kslakylkav
      901 eelknnvted ikmsleeksr dvcakweslh helslyvqql kidiekgkls dnilklekqi
      961 nkekklirrg rtkglikehe acfseegcly qlnhhmevlr elceelpsqk sqqevkrllk
     1021 dyeqkierll kcaseihmtl qptaggtskn egtittsenr ggdphseapf aksdnqpste
     1081 kameptmkfs lasvlrplqe esimekdysa sinslleryd tyrdilehhl qnnkfritsd
     1141 fsseedrsss clqakltdlq viknetdarw kefeiislkl enhvndikkp fvikerdtlk
     1201 ererelqmtl ntrmesleta lrlvlpveka slllcgsdlp lhkmaiqgfh lidadriyqh
     1261 lrniqdsiak qieicnrlee pgnfvlkelh pfdlhamqni ilkyktqfeg mnhrvqrsed
     1321 tlkaledfla slrtaklsae pvtdlsasdt qvaqentltv knkegeihlm kdkakhldkc
     1381 lkmldmsfkd aergddtsce nlldafsikl sethgygvqe efteenklle acifknnell
     1441 kniqdvqsqi skiglkdptv pavkhrkksl irldkvldey eeekrhlqem anslphfkdg
     1501 rektvnqqcq ntvvlwentk alvtecleqc grvlellkqy qnfksilttl iqkeesvisl
     1561 qasymgkenl kkriaeieiv keefnehlev vdkinqvckn lqfylnkmkt feeppfekea
     1621 niivdrwldi nektedyyen lgralalwdk lfnlknvide wtekalqkme lhqlteedre
     1681 rlkeelqvhe qktsefsrrv aeiqfllqss eiplelqvme ssilnkmehv qkcltgesnc
     1741 halsgstael redldqaktq igmtesllka lspsdsleif tkleeiqqqi lqqkhsmill
     1801 enqigcltpe lselkkqyes vsdlfntkks vlqdhfskll ndqcknfndw fsnikvnlke
     1861 cfessetkks veqklqklsd fltlegrnsk ikqvdsvlkh vkkhlpkahv keliswlvgq
     1921 efelekmesi cqarakeled slqqllrlqd dhrnlrkwlt nqeekwkgme epgektelfc
     1981 qalarkreqf esvaqlnnsl keygfteeee iimeatclmd ryqtllrqls eieeedkllp
     2041 tedqsfndla hdvihwikei keslmvlnss egkmpleeri qkikeiillk pegdarieti
     2101 mkqaesseap lvqktltdis nqwdntlhla stylshqekl llegekylqs kedlrlmlie
     2161 lkkkqeagfa lqhglqekka qlkiykkflk kaqdltsllk elksqgnyll ectknpsfse
     2221 epwleikhlh esllqqlqds vqnldghvre hdsyqvcvtd lnttldnfsk efvsfsdkpv
     2281 dqiaveeklq klqelenrls lqdgtlkkil alaksvkqnt ssvgqkiikd dikslqckqk
     2341 dlenrlasak qemecclnsi lkskrstekk gkftlpgrek qatsdvqest qesaavekle
     2401 edweinkdsa vemamskqls lnaqesmknt ederkvnelq nqpleldtml rneqleeiek
     2461 lytqleakka aikpleqtec lnktetgalv lhnigysaqh ldnllqalit lkknkesqyc
     2521 vlrdfqeyla avessmkall tdkeslkvgp ldsvtyldki kkfiasieke kdslgnlkik
     2581 wenlsnhvtd mdkkllesqi kqlehgweqv eqqiqkkysq qvveydeftt lmnkvqdtei
     2641 slqqqqqhlq lrlkspeera gnqsmialtt dlqatkhgfs vlkgqaelqm kriwgekekk
     2701 nledginnlk kqwetleplh leaenqikkc dirnkmketi lwaknllgel npsipllpdd
     2761 ilsqirkckv thdgilarqq sveslaeevk dkvpslttye gsdlnntled lrnqyqmlvl
     2821 kstqrsqqle fkleersnff aiirkfqlmv qesetliipr vetaateael khhhvtleas
     2881 qkelqeidsg isthlqeltn iyeelnvfer lfledqlknl kirtnriqrf iqntcneveh
     2941 kikfcrqfhe ktsalqeead siqrnellln qevnkgvkee iynlkdrlta ikccilqvlk
     3001 lkkvfdyigl nwdfsqldql qtqvfekeke leekikqldt feeehgkyqa llskmraidl
     3061 qikkmtevvl kapdsspesr rlnaqilsqr iekakclcde iikklnenkt fddsfkekei
     3121 lqiklnaeen dklykvlqnm vlelspkeld ekncqdklet slhvlnqiks qlqqpllinl
     3181 eikhiqnekd nceafqeqvw aemcsikavt aiekqreens seasdvetkl refedlqmql
     3241 ntsidlrtnv lndayenltr ykeavtrave sitsleaiii pyrvdvgnpe eslemplrkq
     3301 eelestvahi qdlteklgmi sspeaklqlq ytlqelvskn samkeafkaq eteaerylen
     3361 ykcyrkmeed iytnlskmet vlgqsmsslp lsyrealerl eqskalvsnl istkeelmkl
     3421 rqilrllrlr ctendgicll kivsalwekw lslleaakew emwceelkqe wkfvseeier
     3481 eaiildnlqe elpeisktke aatteelsel ldclcqygen vekqqllltl llqrirsiqn
     3541 vpessgavet vpafqeitsm kercnkllqk vqknkelvqt eiqerhsftk eiialknffq
     3601 qtttsfqnma fqdhpekseq feelqsilkk gkltfenime klrikysemy tivpaeiesq
     3661 veecrkaled idekisnevl ksspsyamrr kieeinnglh nvekmlqqks kniekaqeiq
     3721 kkmwdeldlw hsklneldse vqdiveqdpg qaqewmdnlm ipfqqyqqvs qraecrtsql
     3781 nkatvkmeey sdllksteaw ientshllan padydslrtl shhastvqma ledseqkhnl
     3841 lhsifmdled lsiifetdel tqsiqelsnq vtalqqkime slpqiqrmad dvvaiesevk
     3901 smekrvskik tillskeifd fspeehlkhg evilenirpm kktiaeivsy qvelrlpqtg
     3961 mkplpvfqrt nqllqdikll envtqeqnel lkvvikqtne wdeeienlkq ilnnysaqfs
     4021 lehmspdqad klpqlqgeie rmekqilsln qrkedllvdl katvlnlhqh lkqeqegver
     4081 drlpavtsee ggvaerdase rklnrrgsms ylaaveeeve essvksdngd ekaepspqsw
     4141 sslwkhdkdm eedrassssg tivqeaygki stsdnsmaqi ltpdslnteq gpecslrpnq
     4201 teegttppie adtldssdaq ggleprvekt rpeptevlha cktqvaelel wlqqanvave
     4261 petlnadmqq vleqqlvgcq amlteiehkv aflletckdq glgdngatqh eaealslklk
     4321 tvkcnlekvq mmlqekhsed qhptilkkss epehqealqp vnlselesiv terpqfsrqk
     4381 dfqqqqvlel kpmeqkdfik fiefnakkmw pqycqhdndt tqessasnqa sspendvpds
     4441 ilspqgqngd kwqylhhels skiklplpql vepqvstnmg ilpsvtmynf ryptteelkt
     4501 yttqledlrq easnlqtqen mteeayinld kklfelfltl sqclssveem lemprlyred
     4561 gsgqqvhyet lalelkklyl alsdkkgdll kamtwpgent nlllecfdnl qvclehtqaa
     4621 avcrskslka gldynrsyqn eikrlyhqli ksktslqqsl neisgqsvae qlqkadaytv
     4681 elenaesrva klrdegerlh lpyallqevy kledvldsmw gmlrarytel sspfvtesqq
     4741 dallqgmvel vkigkeklah ghlkqtkskv alqaqienhk vffpeacc
//
LOCUS       XP_011534886            3831 aa            linear   PRI 05-AUG-2025
DEFINITION  nesprin-2 isoform X19 [Homo sapiens].
ACCESSION   XP_011534886
VERSION     XP_011534886.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536584.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..3831
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..3831
                     /product="nesprin-2 isoform X19"
                     /calculated_mol_wt=444510
     Region          28..138
                     /region_name="CH_SYNE2_rpt1"
                     /note="first calponin homology (CH) domain found in
                     synaptic nuclear envelope protein 2; cd21242"
                     /db_xref="CDD:409091"
     Site            order(33,37,89,91..92,95..96,98,107..115,120,122..123,
                     125..126,129..130,133)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409091"
     Region          178..286
                     /region_name="CH_SYNE2_rpt2"
                     /note="second calponin homology (CH) domain found in
                     synaptic nuclear envelope protein 2 (SYNE-2) and similar
                     proteins; cd21244"
                     /db_xref="CDD:409093"
     Site            order(183,187,237,239..240,243..244,246,255..263,270,
                     272..273,275..276,279..280,283)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409093"
     Region          <1418..2014
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          <1868..>2369
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          <2338..2712
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          2805..>3389
                     /region_name="CCDC158"
                     /note="Coiled-coil domain-containing protein 158;
                     pfam15921"
                     /db_xref="CDD:464943"
     CDS             1..3831
                     /gene="SYNE2"
                     /gene_synonym="EDMD5; KASH2; Nesp2; Nesprin-2; NUA;
                     NUANCE; SYNE-2; TROPH"
                     /coded_by="XM_011536584.3:192..11687"
                     /db_xref="GeneID:23224"
                     /db_xref="HGNC:HGNC:17084"
                     /db_xref="MIM:608442"
ORIGIN      
        1 masspelpte deqgswgidd lhislqaeqe dtqkkaftcw insqlarhts psvisdlftd
       61 ikkghvlldl levlsgqqlp rdkgsntfqc riniehaltf lrnrsiklin ihvtdiidgn
      121 psiilgliwt iilhfhiekl aqtlscnynq pslddvsvvd sspassppak kcskvqarwq
      181 msarkalllw aqeqcatyes vnvtdfkssw rngmaflaii halrpdlidm ksvkhrsnkd
      241 nlreafriae qelkiprlle pedvdvvdpd eksimtyvaq flqyskdapg tgeeaqgkvk
      301 damgwltlqk eklqkllkds endtyfkkyn sllsfmesfn eekksfldvl sikrdldeld
      361 kdhlqlreaw dgldhqinaw kiklnyalpp plhqteawlq eveelmdedl sasqdhsqav
      421 tliqekmtlf kslmdrfehh snilltfenk denhlplvpp nkleemkrri nnilekkfil
      481 llefhyykcl vlglvdevks kldiwnikyg sresvellle dwhkfieeke flarldtsfq
      541 kcgeiyknla gecqninkqy mmvksdvcmy rkniynvkst lqkvlacwat yvenlrllra
      601 cfeetkkeei kevpfetlaq wnlehatlne agnflvevsn dvvgssiske lrrlnkrwrk
      661 lvsktqlemn lplmikkqdq ptfdnsgnil skeekatvef stdmsvelpe nynqnikage
      721 khekeneeft gqlkvakdve kligqveiwe aeaksvldqd dvdtsmeesl khliakgsmf
      781 delmarsedm lqmdiqniss qesfqhvltt glqakiqeak ekvqinvvkl iaalknltdv
      841 spdldirlkm eesqkelesy mmraqqllgq respgelisk hkealiisnt kslakylkav
      901 eelknnvted ikmsleeksr dvcakweslh helslyvqql kidiekgkls dnilklekqi
      961 nkekklirrg rtkglikehe acfseegcly qlnhhmevlr elceelpsqk sqqevkrllk
     1021 dyeqkierll kcaseihmtl qptaggtskn egtittsenr ggdphseapf aksdnqpste
     1081 kameptmkfs lasvlrplqe esimekdysa sinslleryd tyrdilehhl qnnkfritsd
     1141 fsseedrsss clqakltdlq viknetdarw kefeiislkl enhvndikkp fvikerdtlk
     1201 ererelqmtl ntrmesleta lrlvlpveka slllcgsdlp lhkmaiqgfh lidadriyqh
     1261 lrniqdsiak qieicnrlee pgnfvlkelh pfdlhamqni ilkyktqfeg mnhrvqrsed
     1321 tlkaledfla slrtaklsae pvtdlsasdt qvaqentltv knkegeihlm kdkakhldkc
     1381 lkmldmsfkd aergddtsce nlldafsikl sethgygvqe efteenklle acifknnell
     1441 kniqdvqsqi skiglkdptv pavkhrkksl irldkvldey eeekrhlqem anslphfkdg
     1501 rektvnqqcq ntvvlwentk alvtecleqc grvlellkqy qnfksilttl iqkeesvisl
     1561 qasymgkenl kkriaeieiv keefnehlev vdkinqvckn lqfylnkmkt feeppfekea
     1621 niivdrwldi nektedyyen lgralalwdk lfnlknvide wtekalqkme lhqlteedre
     1681 rlkeelqvhe qktsefsrrv aeiqfllqss eiplelqvme ssilnkmehv qkcltgesnc
     1741 halsgstael redldqaktq igmtesllka lspsdsleif tkleeiqqqi lqqkhsmill
     1801 enqigcltpe lselkkqyes vsdlfntkks vlqdhfskll ndqcknfndw fsnikvnlke
     1861 cfessetkks veqklqklsd fltlegrnsk ikqvdsvlkh vkkhlpkahv keliswlvgq
     1921 efelekmesi cqarakeled slqqllrlqd dhrnlrkwlt nqeekwkgme epgektelfc
     1981 qalarkreqf esvaqlnnsl keygfteeee iimeatclmd ryqtllrqls eieeedkllp
     2041 tedqsfndla hdvihwikei keslmvlnss egkmpleeri qkikeiillk pegdarieti
     2101 mkqaesseap lvqktltdis nqwdntlhla stylshqekl llegekylqs kedlrlmlie
     2161 lkkkqeagfa lqhglqekka qlkiykkflk kaqdltsllk elksqgnyll ectknpsfse
     2221 epwleikhlh esllqqlqds vqnldghvre hdsyqvcvtd lnttldnfsk efvsfsdkpv
     2281 dqiaveeklq klqelenrls lqdgtlkkil alaksvkqnt ssvgqkiikd dikslqckqk
     2341 dlenrlasak qemecclnsi lkskrstekk gkftlpgrek qatsdvqest qesaavekle
     2401 edweinkdsa vemamskqls lnaqesmknt ederkvnelq nqpleldtml rneqleeiek
     2461 lytqleakka aikpleqtec lnktetgalv lhnigysaqh ldnllqalit lkknkesqyc
     2521 vlrdfqeyla avessmkall tdkeslkvgp ldsvtyldki kkfiasieke kdslgnlkik
     2581 wenlsnhvtd mdkkllesqi kqlehgweqv eqqiqkkysq qvveydeftt lmnkvqdtei
     2641 slqqqqqhlq lrlkspeera gnqsmialtt dlqatkhgfs vlkgqaelqm kriwgekekk
     2701 nledginnlk kqwetleplh leaenqikkc dirnkmketi lwaknllgel npsipllpdd
     2761 ilsqirkckv thdgilarqq sveslaeevk dkvpslttye gsdlnntled lrnqyqmlvl
     2821 kstqrsqqle fkleersnff aiirkfqlmv qesetliipr vetaateael khhhvtleas
     2881 qkelqeidsg isthlqeltn iyeelnvfer lfledqlknl kirtnriqrf iqntcneveh
     2941 kikfcrqfhe ktsalqeead siqrnellln qevnkgvkee iynlkdrlta ikccilqvlk
     3001 lkkvfdyigl nwdfsqldql qtqvfekeke leekikqldt feeehgkyqa llskmraidl
     3061 qikkmtevvl kapdsspesr rlnaqilsqr iekakclcde iikklnenkt fddsfkekei
     3121 lqiklnaeen dklykvlqnm vlelspkeld ekncqdklet slhvlnqiks qlqqpllinl
     3181 eikhiqnekd nceafqeqvw aemcsikavt aiekqreens seasdvetkl refedlqmql
     3241 ntsidlrtnv lndayenltr ykeavtrave sitsleaiii pyrvdvgnpe eslemplrkq
     3301 eelestvahi qdlteklgmi sspeaklqlq ytlqelvskn samkeafkaq eteaerylen
     3361 ykcyrkmeed iytnlskmet vlgqsmsslp lsyrealerl eqskalvsnl istkeelmkl
     3421 rqilrllrlr ctendgicll kivsalwekw lslleaakew emwceelkqe wkfvseeier
     3481 eaiildnlqe elpeisktke aatteelsel ldclcqygen vekqqllltl llqrirsiqn
     3541 vpessgavet vpafqeitsm kercnkllqk vqknkelvqt eiqerhsftk eiialknffq
     3601 qtttsfqnma fqdhpekseq feelqsilkk gkltfenime klrikysemy tivpaeiesq
     3661 veecrkaled idekisnevl ksspsyamrr kieeinnglh nvekmlqqks kniekaqeiq
     3721 kkmwdeldlw hsklneldse vqdiveqdpg qaqewmdnlm ipfqqyqqvs qraecrtsql
     3781 nkatvkmeey sdllksteaw ientshllan padydslrtl shhastvqhf r
//
LOCUS       XP_047287116            2828 aa            linear   PRI 05-AUG-2025
DEFINITION  nesprin-2 isoform X20 [Homo sapiens].
ACCESSION   XP_047287116
VERSION     XP_047287116.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431160.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2828
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2828
                     /product="nesprin-2 isoform X20"
                     /calculated_mol_wt=325479
     Region          <388..1213
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          837..1061
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            946..951
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          955..1168
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Region          1015..>1767
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Site            1060..1065
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1070..1276
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1167..1172
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1811..2025
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1912..1917
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          2029..2242
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            2135..2140
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          2482..2705
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            2588..2593
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          <2797..2828
                     /region_name="KASH"
                     /note="Nuclear envelope localization domain; pfam10541"
                     /db_xref="CDD:463142"
     CDS             1..2828
                     /gene="SYNE2"
                     /gene_synonym="EDMD5; KASH2; Nesp2; Nesprin-2; NUA;
                     NUANCE; SYNE-2; TROPH"
                     /coded_by="XM_047431160.1:257..8743"
                     /db_xref="GeneID:23224"
                     /db_xref="HGNC:HGNC:17084"
                     /db_xref="MIM:608442"
ORIGIN      
        1 msylaaveee veessvksdn gdekaepspq swsslwkhdk dmeedrasss sgtivqeayg
       61 kistsdnsma qiltpdslnt eqgpecslrp nqteegttpp ieadtldssd aqggleprve
      121 ktrpeptevl hacktqvael elwlqqanva vepetlnadm qqvleqqlvg cqamlteieh
      181 kvaflletck dqglgdngat qheaealslk lktvkcnlek vqmmlqekhs edqhptilkk
      241 ssepehqeal qpvnlseles ivterpqfsr qkdfqqqqvl elkpmeqkdf ikfiefnakk
      301 mwpqycqhdn dttqessasn qasspendvp dsilspqgqn gdkwqylhhe lsskiklplp
      361 qlvepqvstn mgilpsvtmy nfryptteel ktyttqledl rqeasnlqtq enmteeayin
      421 ldkklfelfl tlsqclssve emlemprlyr edgsgqqvhy etlalelkkl ylalsdkkgd
      481 llkamtwpge ntnlllecfd nlqvclehtq aaavcrsksl kagldynrsy qneikrlyhq
      541 liksktslqq slneisgqsv aeqlqkaday tvelenaesr vaklrdeger lhlpyallqe
      601 vykledvlds mwgmlraryt elsspfvtes qqdallqgmv elvkigkekl ahghlkqtks
      661 kvalqaqien hkvffqklva dmlliqaysa kilpsllqnr etfwaeqvte vkileeksrq
      721 cgmklqsllq kweefdenya slekdleili stlpsvslve eteerlveri sfyqqikrni
      781 ggkharlyqt lnegkqlvas vscpelegqi akleeqwlsl nkkidhelhr lqallkhlls
      841 ynrdsdqltk wlessqhtln ywkeqslnvs qdldtirsni nnffefskev deksslktav
      901 isignqllhl ketdtatlra slaqfeqkwt mlitqlpdiq eklhqlqmek lpsrkaitem
      961 iswmnnvehq tsdedsvhsp ssasqvkhll qkhkefrmem dykqwivdfv nqsllqlstc
     1021 dveskryert efaehlgemn rqwhrvhgml nrkiqhleql lesitesenk iqilnnwlea
     1081 qeerlktlqk pesvisvqkl lldcqdienq laikskalde lkqsyltles gavplledta
     1141 sridelfqkr ssvltqvnql ktsmqsvlqe wkiydqlyde vnmmtirfwy cmehskpvvl
     1201 sletlrcqve nlqslqdeae ssegsweklq evigklkglc psvaeiieek cqnthkrwtq
     1261 vnqaiadqlq kaqsllqlwk aysnahgeaa arlkqqeakf qqlanismsg nnlaeilppa
     1321 lqdikelqhd vqktkeaflq nssvldrlpq paessthmll pgplhslqra aylekmllvk
     1381 anefefvlsq fkdfgvrles lkglimheee nldrlhqqek enpdsflnhv laltaqspdi
     1441 ehlnevslkl plsdvavktl qnmnrqwira tatalercse lqgiglnekf lyccekwiql
     1501 lekieealkv dvanslpell eqqktykmle aevsinqtia dsyvtqslql ldtteienrp
     1561 efitefsklt drwqnavqgv rqrkgdvdgl vrqwqdftts venlfrfltd tshllsavkg
     1621 qerfslyqtr slihelknke ihfqrrrttc altleagekl llttdlktke svgrrisqlq
     1681 dswkdmepql aemikqfqst vetwdqcekk ikelksrlqv lkaqsedplp elhedlhnek
     1741 elikeleqsl aswtqnlkel qtmkadltrh vlvedvmvlk eqiehlhrqw edlclrvair
     1801 kqeiedrlnt wvvfneknke lcawlvqmen kvlqtadisi eemieklqkd cmeeinlfse
     1861 nklqlkqmgd qlikasnksr aaeiddklnk indrwqhlfd vigsrvkklk etfafiqqld
     1921 knmsnlrtwl arieselskp vvydvcddqe iqkrlaeqqd lqrdieqhsa gvesvfnicd
     1981 vllhdsdaca netecdsiqq ttrsldrrwr nicamsmerr mkieetwrlw qkflddysrf
     2041 edwlksaert aacpnssevl ytsakeelkr feafqrqihe rltqlelink qyrrlarenr
     2101 tdtasrlkqm vhegnqrwdn lqrrvtavlr rlrhftnqre efegtresil vwltemdlql
     2161 tnvehfsesd addkmrqlng fqqeitlntn kidqlivfge qliqksepld avliedelee
     2221 lhrycqevfg rvsrfhrrlt sctpgledek easenetdme dpreiqtdsw rkrgeseeps
     2281 spqslchlva pghersgcet pvsvdsiple wdhtgdvggs ssheedeegp yysalsdvei
     2341 penpeaylkm ttktlkassg ksisdghswh vpdspscpeh hykqmegdrn vppvppasst
     2401 pykppygkll lppgtdggke gprvlngnpq qedgglagit eqqsgtacnw qssreaeyga
     2461 fdrwemiqaq elhnklkikq nlqqlnsdis aittwlkkte aelemlkmak ppsdiqeiel
     2521 rvkrlqeilk afdtykalvv svnvsskefl qtespestel qsrlrqlsll weaaqgavds
     2581 wrgglrqslm qcqgsktrpr sdvlffkdfh qlsqnlllwl asaknrrqka hvtdpkadpr
     2641 allecrrelm qlekelverq pqvdmlqeis nsllikghge dcieaeekvh viekklkqlr
     2701 eqvsqdlmal qgtqnpaspl psfdevdsgd qppatsvpap rakqfravrt tegeeetesr
     2761 vpgstrpqrs flsrvvraal plqlllllll llacllpsse edysctqann farsfypmlr
     2821 ytngpppt
//
LOCUS       XP_016876592             916 aa            linear   PRI 05-AUG-2025
DEFINITION  nesprin-2 isoform X21 [Homo sapiens].
ACCESSION   XP_016876592
VERSION     XP_016876592.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021103.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..916
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..916
                     /product="nesprin-2 isoform X21"
                     /calculated_mol_wt=104980
     Region          19..234
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            128..133
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          131..344
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            237..242
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          570..793
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            676..681
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          <885..916
                     /region_name="KASH"
                     /note="Nuclear envelope localization domain; pfam10541"
                     /db_xref="CDD:463142"
     CDS             1..916
                     /gene="SYNE2"
                     /gene_synonym="EDMD5; KASH2; Nesp2; Nesprin-2; NUA;
                     NUANCE; SYNE-2; TROPH"
                     /coded_by="XM_017021103.3:71..2821"
                     /db_xref="GeneID:23224"
                     /db_xref="HGNC:HGNC:17084"
                     /db_xref="MIM:608442"
ORIGIN      
        1 mifshqqvkk lketfafiqq ldknmsnlrt wlariesels kpvvydvcdd qeiqkrlaeq
       61 qdlqrdieqh sagvesvfni cdvllhdsda canetecdsi qqttrsldrr wrnicamsme
      121 rrmkieetwr lwqkflddys rfedwlksae rtaacpnsse vlytsakeel krfeafqrqi
      181 herltqleli nkqyrrlare nrtdtasrlk qmvhegnqrw dnlqrrvtav lrrlrhftnq
      241 reefegtres ilvwltemdl qltnvehfse sdaddkmrql ngfqqeitln tnkidqlivf
      301 geqliqksep ldavliedel eelhrycqev fgrvsrfhrr ltsctpgled ekeasenetd
      361 medpreiqtd swrkrgesee psspqslchl vapghersgc etpvsvdsip lewdhtgdvg
      421 gsssheedee gpyysalsdv eipenpeayl kmttktlkas sgksisdghs whvpdspscp
      481 ehhykqmegd rnvppvppas stpykppygk lllppgtdgg kegprvlngn pqqedgglag
      541 iteqqsgafd rwemiqaqel hnklkikqnl qqlnsdisai ttwlkkteae lemlkmakpp
      601 sdiqeielrv krlqeilkaf dtykalvvsv nvsskeflqt espestelqs rlrqlsllwe
      661 aaqgavdswr gglrqslmqc qgsktrprsd vlffkdfhql sqnlllwlas aknrrqkahv
      721 tdpkadpral lecrrelmql ekelverqpq vdmlqeisns llikghgedc ieaeekvhvi
      781 ekklkqlreq vsqdlmalqg tqnpasplps fdevdsgdqp patsvpapra kqfravrtte
      841 geeetesrvp gstrpqrsfl srvvraalpl qlllllllll acllpsseed ysctqannfa
      901 rsfypmlryt ngpppt
//
LOCUS       XP_016876593             915 aa            linear   PRI 05-AUG-2025
DEFINITION  nesprin-2 isoform X22 [Homo sapiens].
ACCESSION   XP_016876593
VERSION     XP_016876593.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021104.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..915
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..915
                     /product="nesprin-2 isoform X22"
                     /calculated_mol_wt=104852
     Region          19..234
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            128..133
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          131..344
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            237..242
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          570..793
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            676..681
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          <884..915
                     /region_name="KASH"
                     /note="Nuclear envelope localization domain; pfam10541"
                     /db_xref="CDD:463142"
     CDS             1..915
                     /gene="SYNE2"
                     /gene_synonym="EDMD5; KASH2; Nesp2; Nesprin-2; NUA;
                     NUANCE; SYNE-2; TROPH"
                     /coded_by="XM_017021104.3:71..2818"
                     /db_xref="GeneID:23224"
                     /db_xref="HGNC:HGNC:17084"
                     /db_xref="MIM:608442"
ORIGIN      
        1 mifshqqvkk lketfafiqq ldknmsnlrt wlariesels kpvvydvcdd qeiqkrlaeq
       61 qdlqrdieqh sagvesvfni cdvllhdsda canetecdsi qqttrsldrr wrnicamsme
      121 rrmkieetwr lwqkflddys rfedwlksae rtaacpnsse vlytsakeel krfeafqrqi
      181 herltqleli nkqyrrlare nrtdtasrlk qmvhegnqrw dnlqrrvtav lrrlrhftnq
      241 reefegtres ilvwltemdl qltnvehfse sdaddkmrql ngfqqeitln tnkidqlivf
      301 geqliqksep ldavliedel eelhrycqev fgrvsrfhrr ltsctpgled ekeasenetd
      361 medpreiqtd swrkrgesee psspqslchl vapghersgc etpvsvdsip lewdhtgdvg
      421 gsssheedee gpyysalsdv eipenpeayl kmttktlkas sgksisdghs whvpdspscp
      481 ehhykqmegd rnvppvppas stpykppygk lllppgtdgg kegprvlngn pqqedgglag
      541 iteqqsgafd rwemiqaqel hnklkikqnl qqlnsdisai ttwlkkteae lemlkmakpp
      601 sdiqeielrv krlqeilkaf dtykalvvsv nvsskeflqt espestelqs rlrqlsllwe
      661 aaqgavdswr gglrqslmqc qgsktrprsd vlffkdfhql sqnlllwlas aknrrqkahv
      721 tdpkadpral lecrrelmql ekelverqpq vdmlqeisns llikghgedc ieaeekvhvi
      781 ekklkqlreq vsqdlmalqg tqnpasplps fdevdsgdqp patsvpapra kfravrtteg
      841 eeetesrvpg strpqrsfls rvvraalplq llllllllla cllpsseedy sctqannfar
      901 sfypmlrytn gpppt
//
LOCUS       XP_047287117             892 aa            linear   PRI 05-AUG-2025
DEFINITION  nesprin-2 isoform X23 [Homo sapiens].
ACCESSION   XP_047287117
VERSION     XP_047287117.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431161.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..892
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..892
                     /product="nesprin-2 isoform X23"
                     /calculated_mol_wt=102304
     Region          19..234
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            128..133
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          131..344
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            237..242
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          547..770
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            653..658
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          <861..892
                     /region_name="KASH"
                     /note="Nuclear envelope localization domain; pfam10541"
                     /db_xref="CDD:463142"
     CDS             1..892
                     /gene="SYNE2"
                     /gene_synonym="EDMD5; KASH2; Nesp2; Nesprin-2; NUA;
                     NUANCE; SYNE-2; TROPH"
                     /coded_by="XM_047431161.1:71..2749"
                     /db_xref="GeneID:23224"
                     /db_xref="HGNC:HGNC:17084"
                     /db_xref="MIM:608442"
ORIGIN      
        1 mifshqqvkk lketfafiqq ldknmsnlrt wlariesels kpvvydvcdd qeiqkrlaeq
       61 qdlqrdieqh sagvesvfni cdvllhdsda canetecdsi qqttrsldrr wrnicamsme
      121 rrmkieetwr lwqkflddys rfedwlksae rtaacpnsse vlytsakeel krfeafqrqi
      181 herltqleli nkqyrrlare nrtdtasrlk qmvhegnqrw dnlqrrvtav lrrlrhftnq
      241 reefegtres ilvwltemdl qltnvehfse sdaddkmrql ngfqqeitln tnkidqlivf
      301 geqliqksep ldavliedel eelhrycqev fgrvsrfhrr ltsctpgled ekeasenetd
      361 medpreiqtd swrkrgesee psspqslchl vapghersgc etpvsvdsip lewdhtgdvg
      421 gsssheedee gpyysalsgk sisdghswhv pdspscpehh ykqmegdrnv ppvppasstp
      481 ykppygklll ppgtdggkeg prvlngnpqq edgglagite qqsgafdrwe miqaqelhnk
      541 lkikqnlqql nsdisaittw lkkteaelem lkmakppsdi qeielrvkrl qeilkafdty
      601 kalvvsvnvs skeflqtesp estelqsrlr qlsllweaaq gavdswrggl rqslmqcqgs
      661 ktrprsdvlf fkdfhqlsqn lllwlasakn rrqkahvtdp kadprallec rrelmqleke
      721 lverqpqvdm lqeisnslli kghgedciea eekvhviekk lkqlreqvsq dlmalqgtqn
      781 pasplpsfde vdsgdqppat svpaprakfr avrttegeee tesrvpgstr pqrsflsrvv
      841 raalplqlll llllllacll psseedysct qannfarsfy pmlrytngpp pt
//
LOCUS       XP_006720153             905 aa            linear   PRI 05-AUG-2025
DEFINITION  phosphofurin acidic cluster sorting protein 2 isoform X1 [Homo
            sapiens].
ACCESSION   XP_006720153
VERSION     XP_006720153.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720090.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..905
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..905
                     /product="phosphofurin acidic cluster sorting protein 2
                     isoform X1"
                     /calculated_mol_wt=99626
     Region          478..901
                     /region_name="Pacs-1"
                     /note="PACS-1 cytosolic sorting protein; pfam10254"
                     /db_xref="CDD:463027"
     CDS             1..905
                     /gene="PACS2"
                     /gene_synonym="DEE66; EIEE66; PACS-2; PACS1L"
                     /coded_by="XM_006720090.3:172..2889"
                     /db_xref="GeneID:23241"
                     /db_xref="HGNC:HGNC:23794"
                     /db_xref="MIM:610423"
ORIGIN      
        1 maergrlglp gapgalntpv pmnlfatwev dgsspscvpr lcsltlkklv vfkelekeli
       61 svviavkmqg skrilrshei vlppsgqvet dlaltfslqy phflkregnk lqimlqrrkr
      121 yknrtilgyk tlaagsisma evmqhpsegg qvlslcssik eapvkaaeiw iaslssqpid
      181 hedstmqagp kakstdnyse eeyesfsseq easddavqgq dldeddfdvg kpkkqrrsiv
      241 rttsmtrqqn fkqkvvallr rfkvsdevld seqdpaehip eaeedldlly dtldmehpsd
      301 sgpdmeddds vlstpkpklr pyfeglshss sqteigsihs arshkeppsp advpektrsl
      361 ggrqpsdsvs dtvalqgvpg prehpgqped speaeastld vfterlppsg ritkteslvi
      421 pstrsegkqa grrgrstslk erqaarpqne ransldnerc pdarsqlqvq lqiprktvyd
      481 qlnhilisdd qlpeniilvn tsdwqgqfls dvlqrhtlpv vctcspadvq aafstivsri
      541 qrycncnsqp ptpvkiavag aqhylsailr lfveqlshkt pdwlgymrfl viplgshpva
      601 rylgsvdyry nnffqdlawr dlfnkleaqs avqdtpdivs ritqyiagan cahqlpiaea
      661 mltykqkrkk hfhfdftlsp deessqkfip fvgvvkvgiv epssatsgds ddaapsgsgt
      721 lsstppsasp aakeasptpp sspsvsggls spsqgvgael mglqvdywta aqpadrkrda
      781 ekkdlpvtkn tlkctfrslq vsrlpssgea aatptmsmtv vtkeknkkvm flpkkakdkd
      841 vesksqcieg isrlictarq qqnmlrvlid gvecsdvkff qlaaqwsshv khfpicifgh
      901 skatf
//
LOCUS       XP_016876594             901 aa            linear   PRI 05-AUG-2025
DEFINITION  phosphofurin acidic cluster sorting protein 2 isoform X2 [Homo
            sapiens].
ACCESSION   XP_016876594
VERSION     XP_016876594.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021105.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..901
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..901
                     /product="phosphofurin acidic cluster sorting protein 2
                     isoform X2"
                     /calculated_mol_wt=99157
     Region          474..897
                     /region_name="Pacs-1"
                     /note="PACS-1 cytosolic sorting protein; pfam10254"
                     /db_xref="CDD:463027"
     CDS             1..901
                     /gene="PACS2"
                     /gene_synonym="DEE66; EIEE66; PACS-2; PACS1L"
                     /coded_by="XM_017021105.3:172..2877"
                     /db_xref="GeneID:23241"
                     /db_xref="HGNC:HGNC:23794"
                     /db_xref="MIM:610423"
ORIGIN      
        1 maergrlglp gapgalntpv pmnlfatwev dgsspscvpr lcsltlkklv vfkelekeli
       61 svviavkmqg skrilrshei vlppsgqvet dlaltfslqy phflkregnk lqimlqrrkr
      121 yknrtilgyk tlaagsisma evmqhpsegg qvlslcssik eapvkaaeiw iaslssqpid
      181 hedstmqagp kakstdnyse eeyesfsseq easddavqgq dldeddfdvg kpkkqrrsiv
      241 rttsmtrqqn fkqkvvallr rfkvsdevld seqdpaehip eaeedldlly dtldmehpsd
      301 sgpdmeddds vlstpkpklr pyfeglshss sqteigsihs arshkeppsp advpektrsl
      361 ggrqpsdsvs dtvalqgvpg prehpgqped speaeastld vfterlppsg ritkteslvi
      421 pstrsegkqa grrgrstslk erqaarpqne ransldnerc pdarsqlqip rktvydqlnh
      481 ilisddqlpe niilvntsdw qgqflsdvlq rhtlpvvctc spadvqaafs tivsriqryc
      541 ncnsqpptpv kiavagaqhy lsailrlfve qlshktpdwl gymrflvipl gshpvarylg
      601 svdyrynnff qdlawrdlfn kleaqsavqd tpdivsritq yiagancahq lpiaeamlty
      661 kqkrkkhfhf dftlspdees sqkfipfvgv vkvgivepss atsgdsddaa psgsgtlsst
      721 ppsaspaake asptppssps vsgglsspsq gvgaelmglq vdywtaaqpa drkrdaekkd
      781 lpvtkntlkc tfrslqvsrl pssgeaaatp tmsmtvvtke knkkvmflpk kakdkdvesk
      841 sqciegisrl ictarqqqnm lrvlidgvec sdvkffqlaa qwsshvkhfp icifghskat
      901 f
//
LOCUS       XP_016876595             900 aa            linear   PRI 05-AUG-2025
DEFINITION  phosphofurin acidic cluster sorting protein 2 isoform X3 [Homo
            sapiens].
ACCESSION   XP_016876595
VERSION     XP_016876595.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021106.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..900
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..900
                     /product="phosphofurin acidic cluster sorting protein 2
                     isoform X3"
                     /calculated_mol_wt=99029
     Region          473..896
                     /region_name="Pacs-1"
                     /note="PACS-1 cytosolic sorting protein; pfam10254"
                     /db_xref="CDD:463027"
     CDS             1..900
                     /gene="PACS2"
                     /gene_synonym="DEE66; EIEE66; PACS-2; PACS1L"
                     /coded_by="XM_017021106.3:172..2874"
                     /db_xref="GeneID:23241"
                     /db_xref="HGNC:HGNC:23794"
                     /db_xref="MIM:610423"
ORIGIN      
        1 maergrlglp gapgalntpv pmnlfatwev dgsspscvpr lcsltlkklv vfkelekeli
       61 svviavkmqg skrilrshei vlppsgqvet dlaltfslqy phflkregnk lqimlqrrkr
      121 yknrtilgyk tlaagsisma evmqhpsegg qvlslcssik eapvkaaeiw iaslssqpid
      181 hedstmqagp kakstdnyse eeyesfsseq easddavqgq dldeddfdvg kpkkqrrsiv
      241 rttsmtrqqn fkqkvvallr rfkvsdevld seqdpaehip eaeedldlly dtldmehpsd
      301 sgpdmeddds vlstpkpklr pyfeglshss sqteigsihs arshkeppsp advpektrsl
      361 ggrqpsdsvs dtvalgvpgp rehpgqpeds peaeastldv fterlppsgr itkteslvip
      421 strsegkqag rrgrstslke rqaarpqner ansldnercp darsqlqipr ktvydqlnhi
      481 lisddqlpen iilvntsdwq gqflsdvlqr htlpvvctcs padvqaafst ivsriqrycn
      541 cnsqpptpvk iavagaqhyl sailrlfveq lshktpdwlg ymrflviplg shpvarylgs
      601 vdyrynnffq dlawrdlfnk leaqsavqdt pdivsritqy iagancahql piaeamltyk
      661 qkrkkhfhfd ftlspdeess qkfipfvgvv kvgivepssa tsgdsddaap sgsgtlsstp
      721 psaspaakea sptppsspsv sgglsspsqg vgaelmglqv dywtaaqpad rkrdaekkdl
      781 pvtkntlkct frslqvsrlp ssgeaaatpt msmtvvtkek nkkvmflpkk akdkdvesks
      841 qciegisrli ctarqqqnml rvlidgvecs dvkffqlaaq wsshvkhfpi cifghskatf
//
LOCUS       XP_016876596             897 aa            linear   PRI 05-AUG-2025
DEFINITION  phosphofurin acidic cluster sorting protein 2 isoform X4 [Homo
            sapiens].
ACCESSION   XP_016876596
VERSION     XP_016876596.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021107.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..897
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..897
                     /product="phosphofurin acidic cluster sorting protein 2
                     isoform X4"
                     /calculated_mol_wt=98693
     Region          470..893
                     /region_name="Pacs-1"
                     /note="PACS-1 cytosolic sorting protein; pfam10254"
                     /db_xref="CDD:463027"
     CDS             1..897
                     /gene="PACS2"
                     /gene_synonym="DEE66; EIEE66; PACS-2; PACS1L"
                     /coded_by="XM_017021107.3:172..2865"
                     /db_xref="GeneID:23241"
                     /db_xref="HGNC:HGNC:23794"
                     /db_xref="MIM:610423"
ORIGIN      
        1 maergrlglp gapgalntpv pmnlfatwev dgsspscvpr lcsltlkklv vfkelekeli
       61 svviavkmqg skrilrshei vlppsgqvet dlaltfslqy phflkregnk lqimlqrrkr
      121 yknrtilgyk tlaagsisma evmqhpsegg qvlslcssik eapvkaaeiw iaslssqpid
      181 hedstmqagp kakstdnyse eeyesfsseq easddavqgq dldeddfdvg kpkkqrrsiq
      241 qnfkqkvval lrrfkvsdev ldseqdpaeh ipeaeedldl lydtldmehp sdsgpdmedd
      301 dsvlstpkpk lrpyfeglsh sssqteigsi hsarshkepp spadvpektr slggrqpsds
      361 vsdtvalqgv pgprehpgqp edspeaeast ldvfterlpp sgritktesl vipstrsegk
      421 qagrrgrsts lkerqaarpq neransldne rcpdarsqlq vqlqiprktv ydqlnhilis
      481 ddqlpeniil vntsdwqgqf lsdvlqrhtl pvvctcspad vqaafstivs riqrycncns
      541 qpptpvkiav agaqhylsai lrlfveqlsh ktpdwlgymr flviplgshp varylgsvdy
      601 rynnffqdla wrdlfnklea qsavqdtpdi vsritqyiag ancahqlpia eamltykqkr
      661 kkhfhfdftl spdeessqkf ipfvgvvkvg ivepssatsg dsddaapsgs gtlsstppsa
      721 spaakeaspt ppsspsvsgg lsspsqgvga elmglqvdyw taaqpadrkr daekkdlpvt
      781 kntlkctfrs lqvsrlpssg eaaatptmsm tvvtkeknkk vmflpkkakd kdvesksqci
      841 egisrlicta rqqqnmlrvl idgvecsdvk ffqlaaqwss hvkhfpicif ghskatf
//
LOCUS       XP_016876597             896 aa            linear   PRI 05-AUG-2025
DEFINITION  phosphofurin acidic cluster sorting protein 2 isoform X5 [Homo
            sapiens].
ACCESSION   XP_016876597
VERSION     XP_016876597.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021108.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..896
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..896
                     /product="phosphofurin acidic cluster sorting protein 2
                     isoform X5"
                     /calculated_mol_wt=98565
     Region          469..892
                     /region_name="Pacs-1"
                     /note="PACS-1 cytosolic sorting protein; pfam10254"
                     /db_xref="CDD:463027"
     CDS             1..896
                     /gene="PACS2"
                     /gene_synonym="DEE66; EIEE66; PACS-2; PACS1L"
                     /coded_by="XM_017021108.3:172..2862"
                     /db_xref="GeneID:23241"
                     /db_xref="HGNC:HGNC:23794"
                     /db_xref="MIM:610423"
ORIGIN      
        1 maergrlglp gapgalntpv pmnlfatwev dgsspscvpr lcsltlkklv vfkelekeli
       61 svviavkmqg skrilrshei vlppsgqvet dlaltfslqy phflkregnk lqimlqrrkr
      121 yknrtilgyk tlaagsisma evmqhpsegg qvlslcssik eapvkaaeiw iaslssqpid
      181 hedstmqagp kakstdnyse eeyesfsseq easddavqgq dldeddfdvg kpkkqrrsiq
      241 qnfkqkvval lrrfkvsdev ldseqdpaeh ipeaeedldl lydtldmehp sdsgpdmedd
      301 dsvlstpkpk lrpyfeglsh sssqteigsi hsarshkepp spadvpektr slggrqpsds
      361 vsdtvalgvp gprehpgqpe dspeaeastl dvfterlpps gritkteslv ipstrsegkq
      421 agrrgrstsl kerqaarpqn eransldner cpdarsqlqv qlqiprktvy dqlnhilisd
      481 dqlpeniilv ntsdwqgqfl sdvlqrhtlp vvctcspadv qaafstivsr iqrycncnsq
      541 pptpvkiava gaqhylsail rlfveqlshk tpdwlgymrf lviplgshpv arylgsvdyr
      601 ynnffqdlaw rdlfnkleaq savqdtpdiv sritqyiaga ncahqlpiae amltykqkrk
      661 khfhfdftls pdeessqkfi pfvgvvkvgi vepssatsgd sddaapsgsg tlsstppsas
      721 paakeasptp psspsvsggl sspsqgvgae lmglqvdywt aaqpadrkrd aekkdlpvtk
      781 ntlkctfrsl qvsrlpssge aaatptmsmt vvtkeknkkv mflpkkakdk dvesksqcie
      841 gisrlictar qqqnmlrvli dgvecsdvkf fqlaaqwssh vkhfpicifg hskatf
//
LOCUS       XP_006720154             894 aa            linear   PRI 05-AUG-2025
DEFINITION  phosphofurin acidic cluster sorting protein 2 isoform X6 [Homo
            sapiens].
ACCESSION   XP_006720154
VERSION     XP_006720154.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720091.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..894
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..894
                     /product="phosphofurin acidic cluster sorting protein 2
                     isoform X6"
                     /calculated_mol_wt=98168
     Region          478..890
                     /region_name="Pacs-1"
                     /note="PACS-1 cytosolic sorting protein; pfam10254"
                     /db_xref="CDD:463027"
     CDS             1..894
                     /gene="PACS2"
                     /gene_synonym="DEE66; EIEE66; PACS-2; PACS1L"
                     /coded_by="XM_006720091.3:172..2856"
                     /db_xref="GeneID:23241"
                     /db_xref="HGNC:HGNC:23794"
                     /db_xref="MIM:610423"
ORIGIN      
        1 maergrlglp gapgalntpv pmnlfatwev dgsspscvpr lcsltlkklv vfkelekeli
       61 svviavkmqg skrilrshei vlppsgqvet dlaltfslqy phflkregnk lqimlqrrkr
      121 yknrtilgyk tlaagsisma evmqhpsegg qvlslcssik eapvkaaeiw iaslssqpid
      181 hedstmqagp kakstdnyse eeyesfsseq easddavqgq dldeddfdvg kpkkqrrsiv
      241 rttsmtrqqn fkqkvvallr rfkvsdevld seqdpaehip eaeedldlly dtldmehpsd
      301 sgpdmeddds vlstpkpklr pyfeglshss sqteigsihs arshkeppsp advpektrsl
      361 ggrqpsdsvs dtvalqgvpg prehpgqped speaeastld vfterlppsg ritkteslvi
      421 pstrsegkqa grrgrstslk erqaarpqne ransldnerc pdarsqlqvq lqiprktvyd
      481 qlnhilisdd qlpeniilvn tsdwqgqfls dvlqrhtlpv vctcspadvq aafstivsri
      541 qrycncnsqp ptpvkiavag aqhylsailr lfveqlshkt pdwlgymrfl viplgshpva
      601 rylgsvdyry nnffqdlawr dlfnkleaqs avqdtpdivs ritqyiagan cahqlpiaea
      661 mltykqkspd eessqkfipf vgvvkvgive pssatsgdsd daapsgsgtl sstppsaspa
      721 akeasptpps spsvsgglss psqgvgaelm glqvdywtaa qpadrkrdae kkdlpvtknt
      781 lkctfrslqv srlpssgeaa atptmsmtvv tkeknkkvmf lpkkakdkdv esksqciegi
      841 srlictarqq qnmlrvlidg vecsdvkffq laaqwsshvk hfpicifghs katf
//
LOCUS       XP_016876598             893 aa            linear   PRI 05-AUG-2025
DEFINITION  phosphofurin acidic cluster sorting protein 2 isoform X7 [Homo
            sapiens].
ACCESSION   XP_016876598
VERSION     XP_016876598.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021109.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..893
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..893
                     /product="phosphofurin acidic cluster sorting protein 2
                     isoform X7"
                     /calculated_mol_wt=98040
     Region          477..889
                     /region_name="Pacs-1"
                     /note="PACS-1 cytosolic sorting protein; pfam10254"
                     /db_xref="CDD:463027"
     CDS             1..893
                     /gene="PACS2"
                     /gene_synonym="DEE66; EIEE66; PACS-2; PACS1L"
                     /coded_by="XM_017021109.3:172..2853"
                     /db_xref="GeneID:23241"
                     /db_xref="HGNC:HGNC:23794"
                     /db_xref="MIM:610423"
ORIGIN      
        1 maergrlglp gapgalntpv pmnlfatwev dgsspscvpr lcsltlkklv vfkelekeli
       61 svviavkmqg skrilrshei vlppsgqvet dlaltfslqy phflkregnk lqimlqrrkr
      121 yknrtilgyk tlaagsisma evmqhpsegg qvlslcssik eapvkaaeiw iaslssqpid
      181 hedstmqagp kakstdnyse eeyesfsseq easddavqgq dldeddfdvg kpkkqrrsiv
      241 rttsmtrqqn fkqkvvallr rfkvsdevld seqdpaehip eaeedldlly dtldmehpsd
      301 sgpdmeddds vlstpkpklr pyfeglshss sqteigsihs arshkeppsp advpektrsl
      361 ggrqpsdsvs dtvalgvpgp rehpgqpeds peaeastldv fterlppsgr itkteslvip
      421 strsegkqag rrgrstslke rqaarpqner ansldnercp darsqlqvql qiprktvydq
      481 lnhilisddq lpeniilvnt sdwqgqflsd vlqrhtlpvv ctcspadvqa afstivsriq
      541 rycncnsqpp tpvkiavaga qhylsailrl fveqlshktp dwlgymrflv iplgshpvar
      601 ylgsvdyryn nffqdlawrd lfnkleaqsa vqdtpdivsr itqyiaganc ahqlpiaeam
      661 ltykqkspde essqkfipfv gvvkvgivep ssatsgdsdd aapsgsgtls stppsaspaa
      721 keasptppss psvsgglssp sqgvgaelmg lqvdywtaaq padrkrdaek kdlpvtkntl
      781 kctfrslqvs rlpssgeaaa tptmsmtvvt keknkkvmfl pkkakdkdve sksqciegis
      841 rlictarqqq nmlrvlidgv ecsdvkffql aaqwsshvkh fpicifghsk atf
//
LOCUS       XP_047287119             892 aa            linear   PRI 05-AUG-2025
DEFINITION  phosphofurin acidic cluster sorting protein 2 isoform X8 [Homo
            sapiens].
ACCESSION   XP_047287119
VERSION     XP_047287119.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431163.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..892
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..892
                     /product="phosphofurin acidic cluster sorting protein 2
                     isoform X8"
                     /calculated_mol_wt=98096
     Region          465..888
                     /region_name="Pacs-1"
                     /note="PACS-1 cytosolic sorting protein; pfam10254"
                     /db_xref="CDD:463027"
     CDS             1..892
                     /gene="PACS2"
                     /gene_synonym="DEE66; EIEE66; PACS-2; PACS1L"
                     /coded_by="XM_047431163.1:172..2850"
                     /db_xref="GeneID:23241"
                     /db_xref="HGNC:HGNC:23794"
                     /db_xref="MIM:610423"
ORIGIN      
        1 maergrlglp gapgalntpv pmnlfatwev dgsspscvpr lcsltlkklv vfkelekeli
       61 svviavkmqg skrilrshei vlppsgqvet dlaltfslqy phflkregnk lqimlqrrkr
      121 yknrtilgyk tlaagsisma evmqhpsegg qvlslcssik eapvkaaeiw iaslssqpid
      181 hedstmqagp kakstdnyse eeyesfsseq easddavqgq dldeddfdvg kpkkqrrsiq
      241 qnfkqkvval lrrfkvsdev ldseqdpaeh ipeaeedldl lydtldmehp sdsgpdmedd
      301 dsvlstpkpk lrpyfeglsh sssqteigsi hsarshkepp spadvpektr slggrqpsds
      361 vsdtvalgvp gprehpgqpe dspeaeastl dvfterlpps gritkteslv ipstrsegkq
      421 agrrgrstsl kerqaarpqn eransldner cpdarsqlqi prktvydqln hilisddqlp
      481 eniilvntsd wqgqflsdvl qrhtlpvvct cspadvqaaf stivsriqry cncnsqpptp
      541 vkiavagaqh ylsailrlfv eqlshktpdw lgymrflvip lgshpvaryl gsvdyrynnf
      601 fqdlawrdlf nkleaqsavq dtpdivsrit qyiagancah qlpiaeamlt ykqkrkkhfh
      661 fdftlspdee ssqkfipfvg vvkvgiveps satsgdsdda apsgsgtlss tppsaspaak
      721 easptppssp svsgglssps qgvgaelmgl qvdywtaaqp adrkrdaekk dlpvtkntlk
      781 ctfrslqvsr lpssgeaaat ptmsmtvvtk eknkkvmflp kkakdkdves ksqciegisr
      841 lictarqqqn mlrvlidgve csdvkffqla aqwsshvkhf picifghska tf
//
LOCUS       XP_016876599             890 aa            linear   PRI 05-AUG-2025
DEFINITION  phosphofurin acidic cluster sorting protein 2 isoform X9 [Homo
            sapiens].
ACCESSION   XP_016876599
VERSION     XP_016876599.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021110.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..890
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..890
                     /product="phosphofurin acidic cluster sorting protein 2
                     isoform X9"
                     /calculated_mol_wt=97700
     Region          474..886
                     /region_name="Pacs-1"
                     /note="PACS-1 cytosolic sorting protein; pfam10254"
                     /db_xref="CDD:463027"
     CDS             1..890
                     /gene="PACS2"
                     /gene_synonym="DEE66; EIEE66; PACS-2; PACS1L"
                     /coded_by="XM_017021110.3:172..2844"
                     /db_xref="GeneID:23241"
                     /db_xref="HGNC:HGNC:23794"
                     /db_xref="MIM:610423"
ORIGIN      
        1 maergrlglp gapgalntpv pmnlfatwev dgsspscvpr lcsltlkklv vfkelekeli
       61 svviavkmqg skrilrshei vlppsgqvet dlaltfslqy phflkregnk lqimlqrrkr
      121 yknrtilgyk tlaagsisma evmqhpsegg qvlslcssik eapvkaaeiw iaslssqpid
      181 hedstmqagp kakstdnyse eeyesfsseq easddavqgq dldeddfdvg kpkkqrrsiv
      241 rttsmtrqqn fkqkvvallr rfkvsdevld seqdpaehip eaeedldlly dtldmehpsd
      301 sgpdmeddds vlstpkpklr pyfeglshss sqteigsihs arshkeppsp advpektrsl
      361 ggrqpsdsvs dtvalqgvpg prehpgqped speaeastld vfterlppsg ritkteslvi
      421 pstrsegkqa grrgrstslk erqaarpqne ransldnerc pdarsqlqip rktvydqlnh
      481 ilisddqlpe niilvntsdw qgqflsdvlq rhtlpvvctc spadvqaafs tivsriqryc
      541 ncnsqpptpv kiavagaqhy lsailrlfve qlshktpdwl gymrflvipl gshpvarylg
      601 svdyrynnff qdlawrdlfn kleaqsavqd tpdivsritq yiagancahq lpiaeamlty
      661 kqkspdeess qkfipfvgvv kvgivepssa tsgdsddaap sgsgtlsstp psaspaakea
      721 sptppsspsv sgglsspsqg vgaelmglqv dywtaaqpad rkrdaekkdl pvtkntlkct
      781 frslqvsrlp ssgeaaatpt msmtvvtkek nkkvmflpkk akdkdvesks qciegisrli
      841 ctarqqqnml rvlidgvecs dvkffqlaaq wsshvkhfpi cifghskatf
//
LOCUS       XP_047287120             882 aa            linear   PRI 05-AUG-2025
DEFINITION  phosphofurin acidic cluster sorting protein 2 isoform X10 [Homo
            sapiens].
ACCESSION   XP_047287120
VERSION     XP_047287120.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431164.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..882
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..882
                     /product="phosphofurin acidic cluster sorting protein 2
                     isoform X10"
                     /calculated_mol_wt=96767
     Region          466..878
                     /region_name="Pacs-1"
                     /note="PACS-1 cytosolic sorting protein; pfam10254"
                     /db_xref="CDD:463027"
     CDS             1..882
                     /gene="PACS2"
                     /gene_synonym="DEE66; EIEE66; PACS-2; PACS1L"
                     /coded_by="XM_047431164.1:172..2820"
                     /db_xref="GeneID:23241"
                     /db_xref="HGNC:HGNC:23794"
                     /db_xref="MIM:610423"
ORIGIN      
        1 maergrlglp gapgalntpv pmnlfatwev dgsspscvpr lcsltlkklv vfkelekeli
       61 svviavkmqg skrilrshei vlppsgqvet dlaltfslqy phflkregnk lqimlqrrkr
      121 yknrtilgyk tlaagsisma evmqhpsegg qvlslcssik eapvkaaeiw iaslssqpid
      181 hedstmqagp kakstdnyse eeyesfsseq easddavqgq dldeddfdvg kpkkqrrsiq
      241 qnfkqkvval lrrfkvsdev ldseqdpaeh ipeaeedldl lydtldmehp sdsgpdmedd
      301 dsvlstpkpk lrpyfeglsh sssqteigsi hsarshkepp spadvpektr slggrqpsds
      361 vsdtvalqgv pgprehpgqp edspeaeast ldvfterlpp sgritktesl vipstrsegk
      421 qagrrgrsts lkerqaarpq neransldne rcpdarsqlq iprktvydql nhilisddql
      481 peniilvnts dwqgqflsdv lqrhtlpvvc tcspadvqaa fstivsriqr ycncnsqppt
      541 pvkiavagaq hylsailrlf veqlshktpd wlgymrflvi plgshpvary lgsvdyrynn
      601 ffqdlawrdl fnkleaqsav qdtpdivsri tqyiaganca hqlpiaeaml tykqkspdee
      661 ssqkfipfvg vvkvgiveps satsgdsdda apsgsgtlss tppsaspaak easptppssp
      721 svsgglssps qgvgaelmgl qvdywtaaqp adrkrdaekk dlpvtkntlk ctfrslqvsr
      781 lpssgeaaat ptmsmtvvtk eknkkvmflp kkakdkdves ksqciegisr lictarqqqn
      841 mlrvlidgve csdvkffqla aqwsshvkhf picifghska tf
//
LOCUS       XP_006720155             881 aa            linear   PRI 05-AUG-2025
DEFINITION  phosphofurin acidic cluster sorting protein 2 isoform X11 [Homo
            sapiens].
ACCESSION   XP_006720155
VERSION     XP_006720155.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720092.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..881
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..881
                     /product="phosphofurin acidic cluster sorting protein 2
                     isoform X11"
                     /calculated_mol_wt=96639
     Region          465..877
                     /region_name="Pacs-1"
                     /note="PACS-1 cytosolic sorting protein; pfam10254"
                     /db_xref="CDD:463027"
     CDS             1..881
                     /gene="PACS2"
                     /gene_synonym="DEE66; EIEE66; PACS-2; PACS1L"
                     /coded_by="XM_006720092.4:172..2817"
                     /db_xref="GeneID:23241"
                     /db_xref="HGNC:HGNC:23794"
                     /db_xref="MIM:610423"
ORIGIN      
        1 maergrlglp gapgalntpv pmnlfatwev dgsspscvpr lcsltlkklv vfkelekeli
       61 svviavkmqg skrilrshei vlppsgqvet dlaltfslqy phflkregnk lqimlqrrkr
      121 yknrtilgyk tlaagsisma evmqhpsegg qvlslcssik eapvkaaeiw iaslssqpid
      181 hedstmqagp kakstdnyse eeyesfsseq easddavqgq dldeddfdvg kpkkqrrsiq
      241 qnfkqkvval lrrfkvsdev ldseqdpaeh ipeaeedldl lydtldmehp sdsgpdmedd
      301 dsvlstpkpk lrpyfeglsh sssqteigsi hsarshkepp spadvpektr slggrqpsds
      361 vsdtvalgvp gprehpgqpe dspeaeastl dvfterlpps gritkteslv ipstrsegkq
      421 agrrgrstsl kerqaarpqn eransldner cpdarsqlqi prktvydqln hilisddqlp
      481 eniilvntsd wqgqflsdvl qrhtlpvvct cspadvqaaf stivsriqry cncnsqpptp
      541 vkiavagaqh ylsailrlfv eqlshktpdw lgymrflvip lgshpvaryl gsvdyrynnf
      601 fqdlawrdlf nkleaqsavq dtpdivsrit qyiagancah qlpiaeamlt ykqkspdees
      661 sqkfipfvgv vkvgivepss atsgdsddaa psgsgtlsst ppsaspaake asptppssps
      721 vsgglsspsq gvgaelmglq vdywtaaqpa drkrdaekkd lpvtkntlkc tfrslqvsrl
      781 pssgeaaatp tmsmtvvtke knkkvmflpk kakdkdvesk sqciegisrl ictarqqqnm
      841 lrvlidgvec sdvkffqlaa qwsshvkhfp icifghskat f
//
LOCUS       XP_016876601             838 aa            linear   PRI 05-AUG-2025
DEFINITION  phosphofurin acidic cluster sorting protein 2 isoform X12 [Homo
            sapiens].
ACCESSION   XP_016876601
VERSION     XP_016876601.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021112.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..838
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..838
                     /product="phosphofurin acidic cluster sorting protein 2
                     isoform X12"
                     /calculated_mol_wt=92465
     Region          411..834
                     /region_name="Pacs-1"
                     /note="PACS-1 cytosolic sorting protein; pfam10254"
                     /db_xref="CDD:463027"
     CDS             1..838
                     /gene="PACS2"
                     /gene_synonym="DEE66; EIEE66; PACS-2; PACS1L"
                     /coded_by="XM_017021112.3:289..2805"
                     /db_xref="GeneID:23241"
                     /db_xref="HGNC:HGNC:23794"
                     /db_xref="MIM:610423"
ORIGIN      
        1 mqgskrilrs heivlppsgq vetdlaltfs lqyphflkre gnklqimlqr rkryknrtil
       61 gyktlaagsi smaevmqhps eggqvlslcs sikeapvkaa eiwiaslssq pidhedstmq
      121 agpkakstdn yseeeyesfs seqeasddav qgqdldeddf dvgkpkkqrr sivrttsmtr
      181 qqnfkqkvva llrrfkvsde vldseqdpae hipeaeedld llydtldmeh psdsgpdmed
      241 ddsvlstpkp klrpyfegls hsssqteigs ihsarshkep pspadvpekt rslggrqpsd
      301 svsdtvalqg vpgprehpgq pedspeaeas tldvfterlp psgritktes lvipstrseg
      361 kqagrrgrst slkerqaarp qneransldn ercpdarsql qvqlqiprkt vydqlnhili
      421 sddqlpenii lvntsdwqgq flsdvlqrht lpvvctcspa dvqaafstiv sriqrycncn
      481 sqpptpvkia vagaqhylsa ilrlfveqls hktpdwlgym rflviplgsh pvarylgsvd
      541 yrynnffqdl awrdlfnkle aqsavqdtpd ivsritqyia gancahqlpi aeamltykqk
      601 rkkhfhfdft lspdeessqk fipfvgvvkv givepssats gdsddaapsg sgtlsstpps
      661 aspaakeasp tppsspsvsg glsspsqgvg aelmglqvdy wtaaqpadrk rdaekkdlpv
      721 tkntlkctfr slqvsrlpss geaaatptms mtvvtkeknk kvmflpkkak dkdvesksqc
      781 iegisrlict arqqqnmlrv lidgvecsdv kffqlaaqws shvkhfpici fghskatf
//
LOCUS       XP_016876600             822 aa            linear   PRI 05-AUG-2025
DEFINITION  phosphofurin acidic cluster sorting protein 2 isoform X13 [Homo
            sapiens].
ACCESSION   XP_016876600
VERSION     XP_016876600.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021111.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..822
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..822
                     /product="phosphofurin acidic cluster sorting protein 2
                     isoform X13"
                     /calculated_mol_wt=90411
     Region          406..818
                     /region_name="Pacs-1"
                     /note="PACS-1 cytosolic sorting protein; pfam10254"
                     /db_xref="CDD:463027"
     CDS             1..822
                     /gene="PACS2"
                     /gene_synonym="DEE66; EIEE66; PACS-2; PACS1L"
                     /coded_by="XM_017021111.3:289..2757"
                     /db_xref="GeneID:23241"
                     /db_xref="HGNC:HGNC:23794"
                     /db_xref="MIM:610423"
ORIGIN      
        1 mqgskrilrs heivlppsgq vetdlaltfs lqyphflkre gnklqimlqr rkryknrtil
       61 gyktlaagsi smaevmqhps eggqvlslcs sikeapvkaa eiwiaslssq pidhedstmq
      121 agpkakstdn yseeeyesfs seqeasddav qgqdldeddf dvgkpkkqrr sivrttsmtr
      181 qqnfkqkvva llrrfkvsde vldseqdpae hipeaeedld llydtldmeh psdsgpdmed
      241 ddsvlstpkp klrpyfegls hsssqteigs ihsarshkep pspadvpekt rslggrqpsd
      301 svsdtvalgv pgprehpgqp edspeaeast ldvfterlpp sgritktesl vipstrsegk
      361 qagrrgrsts lkerqaarpq neransldne rcpdarsqlq iprktvydql nhilisddql
      421 peniilvnts dwqgqflsdv lqrhtlpvvc tcspadvqaa fstivsriqr ycncnsqppt
      481 pvkiavagaq hylsailrlf veqlshktpd wlgymrflvi plgshpvary lgsvdyrynn
      541 ffqdlawrdl fnkleaqsav qdtpdivsri tqyiaganca hqlpiaeaml tykqkspdee
      601 ssqkfipfvg vvkvgiveps satsgdsdda apsgsgtlss tppsaspaak easptppssp
      661 svsgglssps qgvgaelmgl qvdywtaaqp adrkrdaekk dlpvtkntlk ctfrslqvsr
      721 lpssgeaaat ptmsmtvvtk eknkkvmflp kkakdkdves ksqciegisr lictarqqqn
      781 mlrvlidgve csdvkffqla aqwsshvkhf picifghska tf
//
LOCUS       XP_005267526             617 aa            linear   PRI 05-AUG-2025
DEFINITION  sec1 family domain-containing protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_005267526
VERSION     XP_005267526.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267469.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..617
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..617
                     /product="sec1 family domain-containing protein 1 isoform
                     X1"
                     /calculated_mol_wt=69796
     Region          19..610
                     /region_name="Sec1"
                     /note="Sec1 family; pfam00995"
                     /db_xref="CDD:460020"
     CDS             1..617
                     /gene="SCFD1"
                     /gene_synonym="C14orf163; RA410; SLY1; SLY1P; STXBP1L2"
                     /coded_by="XM_005267469.3:159..2012"
                     /db_xref="GeneID:23256"
                     /db_xref="HGNC:HGNC:20726"
                     /db_xref="MIM:618207"
ORIGIN      
        1 mlnfnvphik nstgepvwkv liydrfgqdi ispllsvkel rdmgitlhll lhsdrdpipd
       61 vpavyfvmpt eenidrmcqd lrnqlyesyy lnfisaisrs kledianaal aasavtqvak
      121 vfdqylnfit leddmfvlcn qnkelvsyra inrpditdte metvmdtivd slfcffvtlg
      181 avpiircsrg taaemvavkl dkklrenlrd arnslftgdt lgagqfsfqr pllvlvdrni
      241 dlatplhhtw tyqalvhdvl dfhlnrvnle essgvenspa garpkrknkk sydltpvdkf
      301 wqkhkgspfp evaesvqqel esyraqedev krlksimgle gedegaisml sdntakltsa
      361 vsslpellek krlidlhtnv atavlehika rkldvyfeye ekimskttld kslldiisdp
      421 dagtpedkmr lfliyyistq qapseadleq ykkaltdagc nlnplqyikq wkaftkmasa
      481 pasygstttk pmgllsrvmn tgsqfvmegv knlvlkqqnl pvtrildnlm emksnpetdd
      541 yryfdpkmlr gndssvprnk npfqeaivfv vgggnyieyq nlvdyikgkq gkhilygcse
      601 lfnatqfikq lsqlgqk
//
LOCUS       XP_047287121             532 aa            linear   PRI 05-AUG-2025
DEFINITION  sec1 family domain-containing protein 1 isoform X2 [Homo sapiens].
ACCESSION   XP_047287121
VERSION     XP_047287121.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431165.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..532
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..532
                     /product="sec1 family domain-containing protein 1 isoform
                     X2"
                     /calculated_mol_wt=59557
     Region          44..490
                     /region_name="Sec1"
                     /note="Sec1 family; pfam00995"
                     /db_xref="CDD:460020"
     CDS             1..532
                     /gene="SCFD1"
                     /gene_synonym="C14orf163; RA410; SLY1; SLY1P; STXBP1L2"
                     /coded_by="XM_047431165.1:86..1684"
                     /db_xref="GeneID:23256"
                     /db_xref="HGNC:HGNC:20726"
                     /db_xref="MIM:618207"
ORIGIN      
        1 maaaaaataa aaasirerqt valkrmlnfn vphiknstge pvwkvliydr fgqdiispll
       61 svkelrdmgi tlhlllhsdr dpipdvpavy fvmpteenid rmcqdlrnql yesyylnfis
      121 aisrskledi anaalaasav tqvakvfdqy lnfitleddm fvlcnqnkel vsyrainrpd
      181 itdtemetvm dtivdslfcf fvtlgavpii rcsrgtaaem vavkldkklr enlrdarnsl
      241 ftgdtlgagq fsfqrpllvl vdrnidlatp lhhtwtyqal vhdvldfhln rvnleessgv
      301 enspagarpk rknkksydlt pvdkfwqkhk gspfpevaes vqqelesyra qedevkrlks
      361 imglegedeg aismlsdnta kltsavsslp ellekkrlid lhtnvatavl ehikarkldv
      421 yfeyeekims kttldkslld iisdpdagtp edkmrlfliy yistqqapse adleqykkal
      481 tdagcnlnpl qyikqwkaft kmasapasyg stttkpmgcd thgsrnsqdp sv
//
LOCUS       XP_047287122             465 aa            linear   PRI 05-AUG-2025
DEFINITION  sec1 family domain-containing protein 1 isoform X3 [Homo sapiens].
ACCESSION   XP_047287122
VERSION     XP_047287122.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431166.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..465
                     /product="sec1 family domain-containing protein 1 isoform
                     X3"
                     /calculated_mol_wt=52239
     Region          1..423
                     /region_name="Sec1"
                     /note="Sec1 family; pfam00995"
                     /db_xref="CDD:460020"
     CDS             1..465
                     /gene="SCFD1"
                     /gene_synonym="C14orf163; RA410; SLY1; SLY1P; STXBP1L2"
                     /coded_by="XM_047431166.1:216..1613"
                     /db_xref="GeneID:23256"
                     /db_xref="HGNC:HGNC:20726"
                     /db_xref="MIM:618207"
ORIGIN      
        1 mgitlhlllh sdrdpipdvp avyfvmptee nidrmcqdlr nqlyesyyln fisaisrskl
       61 edianaalaa savtqvakvf dqylnfitle ddmfvlcnqn kelvsyrain rpditdteme
      121 tvmdtivdsl fcffvtlgav piircsrgta aemvavkldk klrenlrdar nslftgdtlg
      181 agqfsfqrpl lvlvdrnidl atplhhtwty qalvhdvldf hlnrvnlees sgvenspaga
      241 rpkrknkksy dltpvdkfwq khkgspfpev aesvqqeles yraqedevkr lksimglege
      301 degaismlsd ntakltsavs slpellekkr lidlhtnvat avlehikark ldvyfeyeek
      361 imskttldks lldiisdpda gtpedkmrlf liyyistqqa pseadleqyk kaltdagcnl
      421 nplqyikqwk aftkmasapa sygstttkpm gcdthgsrns qdpsv
//
LOCUS       XP_016876602             424 aa            linear   PRI 05-AUG-2025
DEFINITION  sec1 family domain-containing protein 1 isoform X4 [Homo sapiens].
ACCESSION   XP_016876602
VERSION     XP_016876602.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021113.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..424
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..424
                     /product="sec1 family domain-containing protein 1 isoform
                     X4"
                     /calculated_mol_wt=47406
     Region          44..>414
                     /region_name="Sec1"
                     /note="Sec1 family; pfam00995"
                     /db_xref="CDD:460020"
     CDS             1..424
                     /gene="SCFD1"
                     /gene_synonym="C14orf163; RA410; SLY1; SLY1P; STXBP1L2"
                     /coded_by="XM_017021113.3:86..1360"
                     /db_xref="GeneID:23256"
                     /db_xref="HGNC:HGNC:20726"
                     /db_xref="MIM:618207"
ORIGIN      
        1 maaaaaataa aaasirerqt valkrmlnfn vphiknstge pvwkvliydr fgqdiispll
       61 svkelrdmgi tlhlllhsdr dpipdvpavy fvmpteenid rmcqdlrnql yesyylnfis
      121 aisrskledi anaalaasav tqvakvfdqy lnfitleddm fvlcnqnkel vsyrainrpd
      181 itdtemetvm dtivdslfcf fvtlgavpii rcsrgtaaem vavkldkklr enlrdarnsl
      241 ftgdtlgagq fsfqrpllvl vdrnidlatp lhhtwtyqal vhdvldfhln rvnleessgv
      301 enspagarpk rknkksydlt pvdkfwqkhk gspfpevaes vqqelesyra qedevkrlks
      361 imglegedeg aismlsdnta kltsavsslp ellekkrlid lhtnvatavl ehiklniiag
      421 cqrs
//
LOCUS       XP_011534892             721 aa            linear   PRI 05-AUG-2025
DEFINITION  protein KHNYN isoform X1 [Homo sapiens].
ACCESSION   XP_011534892
VERSION     XP_011534892.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536590.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..721
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..721
                     /product="protein KHNYN isoform X1"
                     /calculated_mol_wt=78841
     Region          55..117
                     /region_name="KH-I_N4BP1_like_rpt1"
                     /note="first type I K homology (KH) RNA-binding domain
                     found in the family of NEDD4-binding protein 1 (N4BP1);
                     cd09032"
                     /db_xref="CDD:411808"
     Region          119..184
                     /region_name="KH-I_NYNRIN_like"
                     /note="type I K homology (KH) RNA-binding domain found in
                     the subfamily of NYN domain and retroviral integrase
                     catalytic domain-containing protein (NYNRIN); cd22477"
                     /db_xref="CDD:411905"
     Site            order(130,132..134,136..140,143..144,147..148,153..156)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:411905"
     Region          479..632
                     /region_name="RNase_Zc3h12a"
                     /note="Zc3h12a-like Ribonuclease NYN domain; pfam11977"
                     /db_xref="CDD:403256"
     CDS             1..721
                     /gene="KHNYN"
                     /gene_synonym="KIAA0323"
                     /coded_by="XM_011536590.3:201..2366"
                     /db_xref="GeneID:23351"
                     /db_xref="HGNC:HGNC:20166"
                     /db_xref="MIM:619579"
ORIGIN      
        1 msggnwiqdw wmriaaltgg gtrlpprqag gsrdgeeglg aaamptwgar paspdrfavs
       61 aeaenkvreq qphverifsv gvsvlpkdcp dnphiwlqle gpkenasrak eylkglcspe
      121 lqdeihyppk lhciflgaqg ffldclawst sahlvprapg slmisgltea fvmaqsrvee
      181 laerlswdft pgpssgasqc tgvlrdfsal lqspgdahre allqlplavq eellslvqea
      241 ssgqgpgala swegrssall gaqcqgvrap psdgresldt gsmgpgdcrg argdtyavek
      301 eggkqggpre mdwgwkelpg eeawereval rpqsvgggar esaplkgkal gkeeialggg
      361 gfcvhreppg ahgschraaq srgasllqrl hngnaspprv pspppapepp whcgdrgdcg
      421 drgdvgdrgd kqqgmargrg pqwkrgargg nlvtgtqrfk ealqdpftlc lanvpgqpdl
      481 rhividgsnv amvhglqhyf ssrgiaiavq yfwdrghrdi tvfvpqwrfs kdakvreshf
      541 lqklyslsll sltpsrvmdg krissyddrf mvklaeetdg iivsndqfrd laeesekwma
      601 iirerllpft fvgnlfmvpd dplgrngptl deflkkpart qgsskaqhps rgfaehgkqq
      661 qgreeekgsg girktreter lrrqllevfw gqdhkvdfil qrepycrdin qlseallsln
      721 f
//
LOCUS       XP_005267531             678 aa            linear   PRI 05-AUG-2025
DEFINITION  protein KHNYN isoform X2 [Homo sapiens].
ACCESSION   XP_005267531
VERSION     XP_005267531.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267474.6
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..678
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..678
                     /product="protein KHNYN isoform X2"
                     /calculated_mol_wt=74403
     Region          12..74
                     /region_name="KH-I_N4BP1_like_rpt1"
                     /note="first type I K homology (KH) RNA-binding domain
                     found in the family of NEDD4-binding protein 1 (N4BP1);
                     cd09032"
                     /db_xref="CDD:411808"
     Region          76..141
                     /region_name="KH-I_NYNRIN_like"
                     /note="type I K homology (KH) RNA-binding domain found in
                     the subfamily of NYN domain and retroviral integrase
                     catalytic domain-containing protein (NYNRIN); cd22477"
                     /db_xref="CDD:411905"
     Site            order(87,89..91,93..97,100..101,104..105,110..113)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:411905"
     Region          436..589
                     /region_name="RNase_Zc3h12a"
                     /note="Zc3h12a-like Ribonuclease NYN domain; pfam11977"
                     /db_xref="CDD:403256"
     CDS             1..678
                     /gene="KHNYN"
                     /gene_synonym="KIAA0323"
                     /coded_by="XM_005267474.6:580..2616"
                     /db_xref="GeneID:23351"
                     /db_xref="HGNC:HGNC:20166"
                     /db_xref="MIM:619579"
ORIGIN      
        1 mptwgarpas pdrfavsaea enkvreqqph verifsvgvs vlpkdcpdnp hiwlqlegpk
       61 enasrakeyl kglcspelqd eihyppklhc iflgaqgffl dclawstsah lvprapgslm
      121 isglteafvm aqsrveelae rlswdftpgp ssgasqctgv lrdfsallqs pgdahreall
      181 qlplavqeel lslvqeassg qgpgalaswe grssallgaq cqgvrappsd gresldtgsm
      241 gpgdcrgarg dtyavekegg kqggpremdw gwkelpgeea werevalrpq svgggaresa
      301 plkgkalgke eialggggfc vhreppgahg schraaqsrg asllqrlhng naspprvpsp
      361 ppapeppwhc gdrgdcgdrg dvgdrgdkqq gmargrgpqw krgarggnlv tgtqrfkeal
      421 qdpftlclan vpgqpdlrhi vidgsnvamv hglqhyfssr giaiavqyfw drghrditvf
      481 vpqwrfskda kvreshflqk lyslsllslt psrvmdgkri ssyddrfmvk laeetdgiiv
      541 sndqfrdlae esekwmaiir erllpftfvg nlfmvpddpl grngptldef lkkpartqgs
      601 skaqhpsrgf aehgkqqqgr eeekgsggir ktreterlrr qllevfwgqd hkvdfilqre
      661 pycrdinqls eallslnf
//
LOCUS       XP_047287123             588 aa            linear   PRI 05-AUG-2025
DEFINITION  protein KHNYN isoform X3 [Homo sapiens].
ACCESSION   XP_047287123
VERSION     XP_047287123.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431167.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..588
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..588
                     /product="protein KHNYN isoform X3"
                     /calculated_mol_wt=63484
     Region          55..117
                     /region_name="KH-I_N4BP1_like_rpt1"
                     /note="first type I K homology (KH) RNA-binding domain
                     found in the family of NEDD4-binding protein 1 (N4BP1);
                     cd09032"
                     /db_xref="CDD:411808"
     Region          119..184
                     /region_name="KH-I_NYNRIN_like"
                     /note="type I K homology (KH) RNA-binding domain found in
                     the subfamily of NYN domain and retroviral integrase
                     catalytic domain-containing protein (NYNRIN); cd22477"
                     /db_xref="CDD:411905"
     Site            order(130,132..134,136..140,143..144,147..148,153..156)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:411905"
     Region          483..>569
                     /region_name="PIN_SF"
                     /note="PIN (PilT N terminus) domain: Superfamily; cl28905"
                     /db_xref="CDD:475124"
     CDS             1..588
                     /gene="KHNYN"
                     /gene_synonym="KIAA0323"
                     /coded_by="XM_047431167.1:201..1967"
                     /db_xref="GeneID:23351"
                     /db_xref="HGNC:HGNC:20166"
                     /db_xref="MIM:619579"
ORIGIN      
        1 msggnwiqdw wmriaaltgg gtrlpprqag gsrdgeeglg aaamptwgar paspdrfavs
       61 aeaenkvreq qphverifsv gvsvlpkdcp dnphiwlqle gpkenasrak eylkglcspe
      121 lqdeihyppk lhciflgaqg ffldclawst sahlvprapg slmisgltea fvmaqsrvee
      181 laerlswdft pgpssgasqc tgvlrdfsal lqspgdahre allqlplavq eellslvqea
      241 ssgqgpgala swegrssall gaqcqgvrap psdgresldt gsmgpgdcrg argdtyavek
      301 eggkqggpre mdwgwkelpg eeawereval rpqsvgggar esaplkgkal gkeeialggg
      361 gfcvhreppg ahgschraaq srgasllqrl hngnaspprv pspppapepp whcgdrgdcg
      421 drgdvgdrgd kqqgmargrg pqwkrgargg nlvtgtqrfk ealqdpftlc lanvpgqpdl
      481 rhividgsnv amvhglqhyf ssrgiaiavq yfwdrghrdi tvfvpqwrfs kdakvreshf
      541 lqklyslsll sltpsrvmdg krissyddrc hrlpkiwnll stpalkqn
//
LOCUS       XP_047287124             588 aa            linear   PRI 05-AUG-2025
DEFINITION  protein KHNYN isoform X3 [Homo sapiens].
ACCESSION   XP_047287124
VERSION     XP_047287124.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431168.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..588
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..588
                     /product="protein KHNYN isoform X3"
                     /calculated_mol_wt=63484
     Region          55..117
                     /region_name="KH-I_N4BP1_like_rpt1"
                     /note="first type I K homology (KH) RNA-binding domain
                     found in the family of NEDD4-binding protein 1 (N4BP1);
                     cd09032"
                     /db_xref="CDD:411808"
     Region          119..184
                     /region_name="KH-I_NYNRIN_like"
                     /note="type I K homology (KH) RNA-binding domain found in
                     the subfamily of NYN domain and retroviral integrase
                     catalytic domain-containing protein (NYNRIN); cd22477"
                     /db_xref="CDD:411905"
     Site            order(130,132..134,136..140,143..144,147..148,153..156)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:411905"
     Region          483..>569
                     /region_name="PIN_SF"
                     /note="PIN (PilT N terminus) domain: Superfamily; cl28905"
                     /db_xref="CDD:475124"
     CDS             1..588
                     /gene="KHNYN"
                     /gene_synonym="KIAA0323"
                     /coded_by="XM_047431168.1:201..1967"
                     /db_xref="GeneID:23351"
                     /db_xref="HGNC:HGNC:20166"
                     /db_xref="MIM:619579"
ORIGIN      
        1 msggnwiqdw wmriaaltgg gtrlpprqag gsrdgeeglg aaamptwgar paspdrfavs
       61 aeaenkvreq qphverifsv gvsvlpkdcp dnphiwlqle gpkenasrak eylkglcspe
      121 lqdeihyppk lhciflgaqg ffldclawst sahlvprapg slmisgltea fvmaqsrvee
      181 laerlswdft pgpssgasqc tgvlrdfsal lqspgdahre allqlplavq eellslvqea
      241 ssgqgpgala swegrssall gaqcqgvrap psdgresldt gsmgpgdcrg argdtyavek
      301 eggkqggpre mdwgwkelpg eeawereval rpqsvgggar esaplkgkal gkeeialggg
      361 gfcvhreppg ahgschraaq srgasllqrl hngnaspprv pspppapepp whcgdrgdcg
      421 drgdvgdrgd kqqgmargrg pqwkrgargg nlvtgtqrfk ealqdpftlc lanvpgqpdl
      481 rhividgsnv amvhglqhyf ssrgiaiavq yfwdrghrdi tvfvpqwrfs kdakvreshf
      541 lqklyslsll sltpsrvmdg krissyddrc hrlpkiwnll stpalkqn
//
LOCUS       XP_047287125             576 aa            linear   PRI 05-AUG-2025
DEFINITION  protein KHNYN isoform X4 [Homo sapiens].
ACCESSION   XP_047287125
VERSION     XP_047287125.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431169.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..576
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..576
                     /product="protein KHNYN isoform X4"
                     /calculated_mol_wt=61948
     Region          55..117
                     /region_name="KH-I_N4BP1_like_rpt1"
                     /note="first type I K homology (KH) RNA-binding domain
                     found in the family of NEDD4-binding protein 1 (N4BP1);
                     cd09032"
                     /db_xref="CDD:411808"
     Region          119..184
                     /region_name="KH-I_NYNRIN_like"
                     /note="type I K homology (KH) RNA-binding domain found in
                     the subfamily of NYN domain and retroviral integrase
                     catalytic domain-containing protein (NYNRIN); cd22477"
                     /db_xref="CDD:411905"
     Site            order(130,132..134,136..140,143..144,147..148,153..156)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:411905"
     Region          483..>569
                     /region_name="PIN_SF"
                     /note="PIN (PilT N terminus) domain: Superfamily; cl28905"
                     /db_xref="CDD:475124"
     CDS             1..576
                     /gene="KHNYN"
                     /gene_synonym="KIAA0323"
                     /coded_by="XM_047431169.1:201..1931"
                     /db_xref="GeneID:23351"
                     /db_xref="HGNC:HGNC:20166"
                     /db_xref="MIM:619579"
ORIGIN      
        1 msggnwiqdw wmriaaltgg gtrlpprqag gsrdgeeglg aaamptwgar paspdrfavs
       61 aeaenkvreq qphverifsv gvsvlpkdcp dnphiwlqle gpkenasrak eylkglcspe
      121 lqdeihyppk lhciflgaqg ffldclawst sahlvprapg slmisgltea fvmaqsrvee
      181 laerlswdft pgpssgasqc tgvlrdfsal lqspgdahre allqlplavq eellslvqea
      241 ssgqgpgala swegrssall gaqcqgvrap psdgresldt gsmgpgdcrg argdtyavek
      301 eggkqggpre mdwgwkelpg eeawereval rpqsvgggar esaplkgkal gkeeialggg
      361 gfcvhreppg ahgschraaq srgasllqrl hngnaspprv pspppapepp whcgdrgdcg
      421 drgdvgdrgd kqqgmargrg pqwkrgargg nlvtgtqrfk ealqdpftlc lanvpgqpdl
      481 rhividgsnv amvhglqhyf ssrgiaiavq yfwdrghrdi tvfvpqwrfs kdakvreshf
      541 lqklyslsll sltpsrvmdg krissyddrq vhgeag
//
LOCUS       XP_011534895            1193 aa            linear   PRI 05-AUG-2025
DEFINITION  apoptosis-stimulating of p53 protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_011534895
VERSION     XP_011534895.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536593.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1193
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1193
                     /product="apoptosis-stimulating of p53 protein 1 isoform
                     X1"
                     /calculated_mol_wt=129681
     Region          72..154
                     /region_name="RA_ASPP1"
                     /note="Ras-associating (RA) domain found in
                     apoptosis-stimulating protein of p53 protein 1 (ASPP1);
                     cd17224"
                     /db_xref="CDD:340744"
     Region          <226..>399
                     /region_name="GumC"
                     /note="Exopolysaccharide export protein/domain GumC/Wzc1
                     [Cell wall/membrane/envelope biogenesis]; COG3206"
                     /db_xref="CDD:442439"
     Region          <548..966
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          995..1081
                     /region_name="Ank_2"
                     /note="Ankyrin repeats (3 copies); pfam12796"
                     /db_xref="CDD:463710"
     Region          995..1021
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(996..997,1000..1002,1004..1005,1009,1012,1021,1023,
                     1025,1029..1030,1033..1035,1037..1038,1042,1045,1054,1056,
                     1058,1062..1063,1066..1068,1070..1071,1075,1078)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          1023..1054
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          1056..1085
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          1125..1181
                     /region_name="SH3_ASPP1"
                     /note="Src Homology 3 domain of Apoptosis Stimulating of
                     p53 protein 1; cd11954"
                     /db_xref="CDD:212887"
     Site            order(1133,1136..1137,1139..1140,1158..1159,1161..1162,
                     1173,1175,1177)
                     /site_type="other"
                     /note="p53 binding site [polypeptide binding]"
                     /db_xref="CDD:212887"
     CDS             1..1193
                     /gene="PPP1R13B"
                     /gene_synonym="ASPP1; p53BP2-like; p85"
                     /coded_by="XM_011536593.4:331..3912"
                     /db_xref="GeneID:23368"
                     /db_xref="HGNC:HGNC:14950"
                     /db_xref="MIM:606455"
ORIGIN      
        1 mwgapsgclp pwqpllrvcs gpcpglchsg aqargggasg dgtagrdpgp gdedrtlpgd
       61 agagprgmla qmiltvflsn neqiltevpi tpettcrdvv efckepgegs chlaevwrgn
      121 erpipfdhmm yehlqkwgpr reevkfflrh edsptenseq ggrqtqeqrt qrnvinvpge
      181 krtengvgnp rveltlselq dmaarqqqqi enqqqmlvak eqrlhflkqq errqqqsise
      241 neklqklker veaqenklkk iramrgqvdy skimngnlsa eierfsamfq ekkqevqtai
      301 lrvdqlsqql edlkkgklng fqsyngkltg paavelkrly qelqirnqln qeqnsklqqq
      361 kellnkrnme vammdkrise lrerlygkki qlnrvngtss pqsplstsgr vaavgpyiqv
      421 psagsfpvlg dpikpqslsi asnaahgrsk sdghskprvt sswtvsdldv gpnygssrps
      481 aspfvnpndg nwptlkqnss ssvkpvqvag adwkdpsveg svkqgtvssq pvpfsalgpt
      541 ekpgieigkv pppipgvgkq lppsygtyps ptplgpgsts slerrkegsl prpsaglpsr
      601 qrptllpatg stpqpgssqq iqqrisvpps ptyppagppa fpagdskpel pltvairpfl
      661 adkgsrpqsp rkgpqtvnss siysmylqqa tppknyqpaa hsalnksvka vygkpvlpsg
      721 stspsplpfl hgslstgtpq pqppsestek epeqdgpaap adgstveslp rplsptkltp
      781 ivhsplryqs dadlealrrk lanaprplkk rssitepegp ggpniqklly qrfntlaggm
      841 egtpfyqpsp sqdfmgtlad vdngntnang nleelppaqp taplpaepap ssdandnelp
      901 spepeelicp qtthqtaepa ednnnnvatv ptteqipspv aeapspgeeq vppaplppas
      961 hppatstnkr tnlkkpnser tghglrvrfn plallldasl egefdlvqri iyevedpskp
     1021 ndegitplhn avcaghhhiv kflldfgvnv naadsdgwtp lhcaascnsv hlckqlvesg
     1081 aaifastisd ietaadkcee meegyiqcsq flygvqeklg vmnkgvayal wdyeaqnsde
     1141 lsfhegdalt ilrrkdeset ewwwarlgdr egyvpknllg lyprikprqr tla
//
LOCUS       XP_005267544            1158 aa            linear   PRI 05-AUG-2025
DEFINITION  apoptosis-stimulating of p53 protein 1 isoform X2 [Homo sapiens].
ACCESSION   XP_005267544
VERSION     XP_005267544.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267487.6
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1158
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1158
                     /product="apoptosis-stimulating of p53 protein 1 isoform
                     X2"
                     /calculated_mol_wt=125968
     Region          72..154
                     /region_name="RA_ASPP1"
                     /note="Ras-associating (RA) domain found in
                     apoptosis-stimulating protein of p53 protein 1 (ASPP1);
                     cd17224"
                     /db_xref="CDD:340744"
     Region          <226..>399
                     /region_name="GumC"
                     /note="Exopolysaccharide export protein/domain GumC/Wzc1
                     [Cell wall/membrane/envelope biogenesis]; COG3206"
                     /db_xref="CDD:442439"
     Region          <513..931
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          960..1046
                     /region_name="Ank_2"
                     /note="Ankyrin repeats (3 copies); pfam12796"
                     /db_xref="CDD:463710"
     Region          960..986
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(961..962,965..967,969..970,974,977,986,988,990,
                     994..995,998..1000,1002..1003,1007,1010,1019,1021,1023,
                     1027..1028,1031..1033,1035..1036,1040,1043)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          988..1019
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          1021..1050
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          1090..1146
                     /region_name="SH3_ASPP1"
                     /note="Src Homology 3 domain of Apoptosis Stimulating of
                     p53 protein 1; cd11954"
                     /db_xref="CDD:212887"
     Site            order(1098,1101..1102,1104..1105,1123..1124,1126..1127,
                     1138,1140,1142)
                     /site_type="other"
                     /note="p53 binding site [polypeptide binding]"
                     /db_xref="CDD:212887"
     CDS             1..1158
                     /gene="PPP1R13B"
                     /gene_synonym="ASPP1; p53BP2-like; p85"
                     /coded_by="XM_005267487.6:331..3807"
                     /db_xref="GeneID:23368"
                     /db_xref="HGNC:HGNC:14950"
                     /db_xref="MIM:606455"
ORIGIN      
        1 mwgapsgclp pwqpllrvcs gpcpglchsg aqargggasg dgtagrdpgp gdedrtlpgd
       61 agagprgmla qmiltvflsn neqiltevpi tpettcrdvv efckepgegs chlaevwrgn
      121 erpipfdhmm yehlqkwgpr reevkfflrh edsptenseq ggrqtqeqrt qrnvinvpge
      181 krtengvgnp rveltlselq dmaarqqqqi enqqqmlvak eqrlhflkqq errqqqsise
      241 neklqklker veaqenklkk iramrgqvdy skimngnlsa eierfsamfq ekkqevqtai
      301 lrvdqlsqql edlkkgklng fqsyngkltg paavelkrly qelqirnqln qeqnsklqqq
      361 kellnkrnme vammdkrise lrerlygkki qlnrvngtss pqsplstsgr vaavgpyiqv
      421 psagsfpvlg dpikpqslsi asnaahgrsk sandgnwptl kqnssssvkp vqvagadwkd
      481 psvegsvkqg tvssqpvpfs algptekpgi eigkvpppip gvgkqlppsy gtypsptplg
      541 pgstsslerr kegslprpsa glpsrqrptl lpatgstpqp gssqqiqqri svppsptypp
      601 agppafpagd skpelpltva irpfladkgs rpqsprkgpq tvnsssiysm ylqqatppkn
      661 yqpaahsaln ksvkavygkp vlpsgstsps plpflhgsls tgtpqpqpps estekepeqd
      721 gpaapadgst veslprplsp tkltpivhsp lryqsdadle alrrklanap rplkkrssit
      781 epegpggpni qkllyqrfnt laggmegtpf yqpspsqdfm gtladvdngn tnangnleel
      841 ppaqptaplp aepapssdan dnelpspepe elicpqtthq taepaednnn nvatvptteq
      901 ipspvaeaps pgeeqvppap lppashppat stnkrtnlkk pnsertghgl rvrfnplall
      961 ldaslegefd lvqriiyeve dpskpndegi tplhnavcag hhhivkflld fgvnvnaads
     1021 dgwtplhcaa scnsvhlckq lvesgaaifa stisdietaa dkceemeegy iqcsqflygv
     1081 qeklgvmnkg vayalwdyea qnsdelsfhe gdaltilrrk desetewwwa rlgdregyvp
     1141 knllglypri kprqrtla
//
LOCUS       XP_016876605            1125 aa            linear   PRI 05-AUG-2025
DEFINITION  apoptosis-stimulating of p53 protein 1 isoform X3 [Homo sapiens].
ACCESSION   XP_016876605
VERSION     XP_016876605.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021116.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1125
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1125
                     /product="apoptosis-stimulating of p53 protein 1 isoform
                     X3"
                     /calculated_mol_wt=123148
     Region          2..86
                     /region_name="RA_ASPP1"
                     /note="Ras-associating (RA) domain found in
                     apoptosis-stimulating protein of p53 protein 1 (ASPP1);
                     cd17224"
                     /db_xref="CDD:340744"
     Region          <158..>331
                     /region_name="GumC"
                     /note="Exopolysaccharide export protein/domain GumC/Wzc1
                     [Cell wall/membrane/envelope biogenesis]; COG3206"
                     /db_xref="CDD:442439"
     Region          <480..898
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          927..1013
                     /region_name="Ank_2"
                     /note="Ankyrin repeats (3 copies); pfam12796"
                     /db_xref="CDD:463710"
     Region          927..953
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(928..929,932..934,936..937,941,944,953,955,957,
                     961..962,965..967,969..970,974,977,986,988,990,994..995,
                     998..1000,1002..1003,1007,1010)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          955..986
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          988..1017
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          1057..1113
                     /region_name="SH3_ASPP1"
                     /note="Src Homology 3 domain of Apoptosis Stimulating of
                     p53 protein 1; cd11954"
                     /db_xref="CDD:212887"
     Site            order(1065,1068..1069,1071..1072,1090..1091,1093..1094,
                     1105,1107,1109)
                     /site_type="other"
                     /note="p53 binding site [polypeptide binding]"
                     /db_xref="CDD:212887"
     CDS             1..1125
                     /gene="PPP1R13B"
                     /gene_synonym="ASPP1; p53BP2-like; p85"
                     /coded_by="XM_017021116.2:269..3646"
                     /db_xref="GeneID:23368"
                     /db_xref="HGNC:HGNC:14950"
                     /db_xref="MIM:606455"
ORIGIN      
        1 mmpmiltvfl snneqiltev pitpettcrd vvefckepge gschlaevwr gnerpipfdh
       61 mmyehlqkwg prreevkffl rhedsptens eqggrqtqeq rtqrnvinvp gekrtengvg
      121 nprveltlse lqdmaarqqq qienqqqmlv akeqrlhflk qqerrqqqsi seneklqklk
      181 erveaqenkl kkiramrgqv dyskimngnl saeierfsam fqekkqevqt ailrvdqlsq
      241 qledlkkgkl ngfqsyngkl tgpaavelkr lyqelqirnq lnqeqnsklq qqkellnkrn
      301 mevammdkri selrerlygk kiqlnrvngt sspqsplsts grvaavgpyi qvpsagsfpv
      361 lgdpikpqsl siasnaahgr sksdghskpr vtsswtvsdl dvgpnygssr psaspfvnpn
      421 dgnwptlkqn ssssvkpvqv agadwkdpsv egsvkqgtvs sqpvpfsalg ptekpgieig
      481 kvpppipgvg kqlppsygty psptplgpgs tsslerrkeg slprpsaglp srqrptllpa
      541 tgstpqpgss qqiqqrisvp psptyppagp pafpagdskp elpltvairp fladkgsrpq
      601 sprkgpqtvn sssiysmylq qatppknyqp aahsalnksv kavygkpvlp sgstspsplp
      661 flhgslstgt pqpqppsest ekepeqdgpa apadgstves lprplsptkl tpivhsplry
      721 qsdadlealr rklanaprpl kkrssitepe gpggpniqkl lyqrfntlag gmegtpfyqp
      781 spsqdfmgtl advdngntna ngnleelppa qptaplpaep apssdandne lpspepeeli
      841 cpqtthqtae paednnnnva tvptteqips pvaeapspge eqvppaplpp ashppatstn
      901 krtnlkkpns ertghglrvr fnplalllda slegefdlvq riiyevedps kpndegitpl
      961 hnavcaghhh ivkflldfgv nvnaadsdgw tplhcaascn svhlckqlve sgaaifasti
     1021 sdietaadkc eemeegyiqc sqflygvqek lgvmnkgvay alwdyeaqns delsfhegda
     1081 ltilrrkdes etewwwarlg dregyvpknl lglyprikpr qrtla
//
LOCUS       XP_016876606            1122 aa            linear   PRI 05-AUG-2025
DEFINITION  apoptosis-stimulating of p53 protein 1 isoform X4 [Homo sapiens].
ACCESSION   XP_016876606
VERSION     XP_016876606.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021117.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1122
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1122
                     /product="apoptosis-stimulating of p53 protein 1 isoform
                     X4"
                     /calculated_mol_wt=122788
     Region          1..83
                     /region_name="RA_ASPP1"
                     /note="Ras-associating (RA) domain found in
                     apoptosis-stimulating protein of p53 protein 1 (ASPP1);
                     cd17224"
                     /db_xref="CDD:340744"
     Region          <155..>328
                     /region_name="GumC"
                     /note="Exopolysaccharide export protein/domain GumC/Wzc1
                     [Cell wall/membrane/envelope biogenesis]; COG3206"
                     /db_xref="CDD:442439"
     Region          <477..895
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          924..1010
                     /region_name="Ank_2"
                     /note="Ankyrin repeats (3 copies); pfam12796"
                     /db_xref="CDD:463710"
     Region          924..950
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(925..926,929..931,933..934,938,941,950,952,954,
                     958..959,962..964,966..967,971,974,983,985,987,991..992,
                     995..997,999..1000,1004,1007)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          952..983
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          985..1014
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          1054..1110
                     /region_name="SH3_ASPP1"
                     /note="Src Homology 3 domain of Apoptosis Stimulating of
                     p53 protein 1; cd11954"
                     /db_xref="CDD:212887"
     Site            order(1062,1065..1066,1068..1069,1087..1088,1090..1091,
                     1102,1104,1106)
                     /site_type="other"
                     /note="p53 binding site [polypeptide binding]"
                     /db_xref="CDD:212887"
     CDS             1..1122
                     /gene="PPP1R13B"
                     /gene_synonym="ASPP1; p53BP2-like; p85"
                     /coded_by="XM_017021117.2:129..3497"
                     /db_xref="GeneID:23368"
                     /db_xref="HGNC:HGNC:14950"
                     /db_xref="MIM:606455"
ORIGIN      
        1 miltvflsnn eqiltevpit pettcrdvve fckepgegsc hlaevwrgne rpipfdhmmy
       61 ehlqkwgprr eevkfflrhe dsptenseqg grqtqeqrtq rnvinvpgek rtengvgnpr
      121 veltlselqd maarqqqqie nqqqmlvake qrlhflkqqe rrqqqsisen eklqklkerv
      181 eaqenklkki ramrgqvdys kimngnlsae ierfsamfqe kkqevqtail rvdqlsqqle
      241 dlkkgklngf qsyngkltgp aavelkrlyq elqirnqlnq eqnsklqqqk ellnkrnmev
      301 ammdkrisel rerlygkkiq lnrvngtssp qsplstsgrv aavgpyiqvp sagsfpvlgd
      361 pikpqslsia snaahgrsks dghskprvts swtvsdldvg pnygssrpsa spfvnpndgn
      421 wptlkqnsss svkpvqvaga dwkdpsvegs vkqgtvssqp vpfsalgpte kpgieigkvp
      481 ppipgvgkql ppsygtypsp tplgpgstss lerrkegslp rpsaglpsrq rptllpatgs
      541 tpqpgssqqi qqrisvppsp typpagppaf pagdskpelp ltvairpfla dkgsrpqspr
      601 kgpqtvnsss iysmylqqat ppknyqpaah salnksvkav ygkpvlpsgs tspsplpflh
      661 gslstgtpqp qppsesteke peqdgpaapa dgstveslpr plsptkltpi vhsplryqsd
      721 adlealrrkl anaprplkkr ssitepegpg gpniqkllyq rfntlaggme gtpfyqpsps
      781 qdfmgtladv dngntnangn leelppaqpt aplpaepaps sdandnelps pepeelicpq
      841 tthqtaepae dnnnnvatvp tteqipspva eapspgeeqv ppaplppash ppatstnkrt
      901 nlkkpnsert ghglrvrfnp lallldasle gefdlvqrii yevedpskpn degitplhna
      961 vcaghhhivk flldfgvnvn aadsdgwtpl hcaascnsvh lckqlvesga aifastisdi
     1021 etaadkceem eegyiqcsqf lygvqeklgv mnkgvayalw dyeaqnsdel sfhegdalti
     1081 lrrkdesete wwwarlgdre gyvpknllgl yprikprqrt la
//
LOCUS       XP_047287126            1122 aa            linear   PRI 05-AUG-2025
DEFINITION  apoptosis-stimulating of p53 protein 1 isoform X4 [Homo sapiens].
ACCESSION   XP_047287126
VERSION     XP_047287126.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431170.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1122
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1122
                     /product="apoptosis-stimulating of p53 protein 1 isoform
                     X4"
                     /calculated_mol_wt=122788
     Region          1..83
                     /region_name="RA_ASPP1"
                     /note="Ras-associating (RA) domain found in
                     apoptosis-stimulating protein of p53 protein 1 (ASPP1);
                     cd17224"
                     /db_xref="CDD:340744"
     Region          <155..>328
                     /region_name="GumC"
                     /note="Exopolysaccharide export protein/domain GumC/Wzc1
                     [Cell wall/membrane/envelope biogenesis]; COG3206"
                     /db_xref="CDD:442439"
     Region          <477..895
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          924..1010
                     /region_name="Ank_2"
                     /note="Ankyrin repeats (3 copies); pfam12796"
                     /db_xref="CDD:463710"
     Region          924..950
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(925..926,929..931,933..934,938,941,950,952,954,
                     958..959,962..964,966..967,971,974,983,985,987,991..992,
                     995..997,999..1000,1004,1007)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          952..983
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          985..1014
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          1054..1110
                     /region_name="SH3_ASPP1"
                     /note="Src Homology 3 domain of Apoptosis Stimulating of
                     p53 protein 1; cd11954"
                     /db_xref="CDD:212887"
     Site            order(1062,1065..1066,1068..1069,1087..1088,1090..1091,
                     1102,1104,1106)
                     /site_type="other"
                     /note="p53 binding site [polypeptide binding]"
                     /db_xref="CDD:212887"
     CDS             1..1122
                     /gene="PPP1R13B"
                     /gene_synonym="ASPP1; p53BP2-like; p85"
                     /coded_by="XM_047431170.1:23..3391"
                     /db_xref="GeneID:23368"
                     /db_xref="HGNC:HGNC:14950"
                     /db_xref="MIM:606455"
ORIGIN      
        1 miltvflsnn eqiltevpit pettcrdvve fckepgegsc hlaevwrgne rpipfdhmmy
       61 ehlqkwgprr eevkfflrhe dsptenseqg grqtqeqrtq rnvinvpgek rtengvgnpr
      121 veltlselqd maarqqqqie nqqqmlvake qrlhflkqqe rrqqqsisen eklqklkerv
      181 eaqenklkki ramrgqvdys kimngnlsae ierfsamfqe kkqevqtail rvdqlsqqle
      241 dlkkgklngf qsyngkltgp aavelkrlyq elqirnqlnq eqnsklqqqk ellnkrnmev
      301 ammdkrisel rerlygkkiq lnrvngtssp qsplstsgrv aavgpyiqvp sagsfpvlgd
      361 pikpqslsia snaahgrsks dghskprvts swtvsdldvg pnygssrpsa spfvnpndgn
      421 wptlkqnsss svkpvqvaga dwkdpsvegs vkqgtvssqp vpfsalgpte kpgieigkvp
      481 ppipgvgkql ppsygtypsp tplgpgstss lerrkegslp rpsaglpsrq rptllpatgs
      541 tpqpgssqqi qqrisvppsp typpagppaf pagdskpelp ltvairpfla dkgsrpqspr
      601 kgpqtvnsss iysmylqqat ppknyqpaah salnksvkav ygkpvlpsgs tspsplpflh
      661 gslstgtpqp qppsesteke peqdgpaapa dgstveslpr plsptkltpi vhsplryqsd
      721 adlealrrkl anaprplkkr ssitepegpg gpniqkllyq rfntlaggme gtpfyqpsps
      781 qdfmgtladv dngntnangn leelppaqpt aplpaepaps sdandnelps pepeelicpq
      841 tthqtaepae dnnnnvatvp tteqipspva eapspgeeqv ppaplppash ppatstnkrt
      901 nlkkpnsert ghglrvrfnp lallldasle gefdlvqrii yevedpskpn degitplhna
      961 vcaghhhivk flldfgvnvn aadsdgwtpl hcaascnsvh lckqlvesga aifastisdi
     1021 etaadkceem eegyiqcsqf lygvqeklgv mnkgvayalw dyeaqnsdel sfhegdalti
     1081 lrrkdesete wwwarlgdre gyvpknllgl yprikprqrt la
//
LOCUS       XP_047287127            1087 aa            linear   PRI 05-AUG-2025
DEFINITION  apoptosis-stimulating of p53 protein 1 isoform X5 [Homo sapiens].
ACCESSION   XP_047287127
VERSION     XP_047287127.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431171.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1087
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1087
                     /product="apoptosis-stimulating of p53 protein 1 isoform
                     X5"
                     /calculated_mol_wt=119075
     Region          1..83
                     /region_name="RA_ASPP1"
                     /note="Ras-associating (RA) domain found in
                     apoptosis-stimulating protein of p53 protein 1 (ASPP1);
                     cd17224"
                     /db_xref="CDD:340744"
     Region          <155..>328
                     /region_name="GumC"
                     /note="Exopolysaccharide export protein/domain GumC/Wzc1
                     [Cell wall/membrane/envelope biogenesis]; COG3206"
                     /db_xref="CDD:442439"
     Region          <442..860
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          889..975
                     /region_name="Ank_2"
                     /note="Ankyrin repeats (3 copies); pfam12796"
                     /db_xref="CDD:463710"
     Region          889..915
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(890..891,894..896,898..899,903,906,915,917,919,
                     923..924,927..929,931..932,936,939,948,950,952,956..957,
                     960..962,964..965,969,972)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          917..948
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          950..979
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          1019..1075
                     /region_name="SH3_ASPP1"
                     /note="Src Homology 3 domain of Apoptosis Stimulating of
                     p53 protein 1; cd11954"
                     /db_xref="CDD:212887"
     Site            order(1027,1030..1031,1033..1034,1052..1053,1055..1056,
                     1067,1069,1071)
                     /site_type="other"
                     /note="p53 binding site [polypeptide binding]"
                     /db_xref="CDD:212887"
     CDS             1..1087
                     /gene="PPP1R13B"
                     /gene_synonym="ASPP1; p53BP2-like; p85"
                     /coded_by="XM_047431171.1:129..3392"
                     /db_xref="GeneID:23368"
                     /db_xref="HGNC:HGNC:14950"
                     /db_xref="MIM:606455"
ORIGIN      
        1 miltvflsnn eqiltevpit pettcrdvve fckepgegsc hlaevwrgne rpipfdhmmy
       61 ehlqkwgprr eevkfflrhe dsptenseqg grqtqeqrtq rnvinvpgek rtengvgnpr
      121 veltlselqd maarqqqqie nqqqmlvake qrlhflkqqe rrqqqsisen eklqklkerv
      181 eaqenklkki ramrgqvdys kimngnlsae ierfsamfqe kkqevqtail rvdqlsqqle
      241 dlkkgklngf qsyngkltgp aavelkrlyq elqirnqlnq eqnsklqqqk ellnkrnmev
      301 ammdkrisel rerlygkkiq lnrvngtssp qsplstsgrv aavgpyiqvp sagsfpvlgd
      361 pikpqslsia snaahgrsks andgnwptlk qnssssvkpv qvagadwkdp svegsvkqgt
      421 vssqpvpfsa lgptekpgie igkvpppipg vgkqlppsyg typsptplgp gstsslerrk
      481 egslprpsag lpsrqrptll patgstpqpg ssqqiqqris vppsptyppa gppafpagds
      541 kpelpltvai rpfladkgsr pqsprkgpqt vnsssiysmy lqqatppkny qpaahsalnk
      601 svkavygkpv lpsgstspsp lpflhgslst gtpqpqppse stekepeqdg paapadgstv
      661 eslprplspt kltpivhspl ryqsdadlea lrrklanapr plkkrssite pegpggpniq
      721 kllyqrfntl aggmegtpfy qpspsqdfmg tladvdngnt nangnleelp paqptaplpa
      781 epapssdand nelpspepee licpqtthqt aepaednnnn vatvptteqi pspvaeapsp
      841 geeqvppapl ppashppats tnkrtnlkkp nsertghglr vrfnplalll daslegefdl
      901 vqriiyeved pskpndegit plhnavcagh hhivkflldf gvnvnaadsd gwtplhcaas
      961 cnsvhlckql vesgaaifas tisdietaad kceemeegyi qcsqflygvq eklgvmnkgv
     1021 ayalwdyeaq nsdelsfheg daltilrrkd esetewwwar lgdregyvpk nllglyprik
     1081 prqrtla
//
LOCUS       XP_047287128            1082 aa            linear   PRI 05-AUG-2025
DEFINITION  apoptosis-stimulating of p53 protein 1 isoform X6 [Homo sapiens].
ACCESSION   XP_047287128
VERSION     XP_047287128.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431172.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1082
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1082
                     /product="apoptosis-stimulating of p53 protein 1 isoform
                     X6"
                     /calculated_mol_wt=116782
     Region          72..154
                     /region_name="RA_ASPP1"
                     /note="Ras-associating (RA) domain found in
                     apoptosis-stimulating protein of p53 protein 1 (ASPP1);
                     cd17224"
                     /db_xref="CDD:340744"
     Region          <226..>399
                     /region_name="GumC"
                     /note="Exopolysaccharide export protein/domain GumC/Wzc1
                     [Cell wall/membrane/envelope biogenesis]; COG3206"
                     /db_xref="CDD:442439"
     Region          <548..966
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          <993..>1058
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          995..1021
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          1023..1054
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     CDS             1..1082
                     /gene="PPP1R13B"
                     /gene_synonym="ASPP1; p53BP2-like; p85"
                     /coded_by="XM_047431172.1:331..3579"
                     /db_xref="GeneID:23368"
                     /db_xref="HGNC:HGNC:14950"
                     /db_xref="MIM:606455"
ORIGIN      
        1 mwgapsgclp pwqpllrvcs gpcpglchsg aqargggasg dgtagrdpgp gdedrtlpgd
       61 agagprgmla qmiltvflsn neqiltevpi tpettcrdvv efckepgegs chlaevwrgn
      121 erpipfdhmm yehlqkwgpr reevkfflrh edsptenseq ggrqtqeqrt qrnvinvpge
      181 krtengvgnp rveltlselq dmaarqqqqi enqqqmlvak eqrlhflkqq errqqqsise
      241 neklqklker veaqenklkk iramrgqvdy skimngnlsa eierfsamfq ekkqevqtai
      301 lrvdqlsqql edlkkgklng fqsyngkltg paavelkrly qelqirnqln qeqnsklqqq
      361 kellnkrnme vammdkrise lrerlygkki qlnrvngtss pqsplstsgr vaavgpyiqv
      421 psagsfpvlg dpikpqslsi asnaahgrsk sdghskprvt sswtvsdldv gpnygssrps
      481 aspfvnpndg nwptlkqnss ssvkpvqvag adwkdpsveg svkqgtvssq pvpfsalgpt
      541 ekpgieigkv pppipgvgkq lppsygtyps ptplgpgsts slerrkegsl prpsaglpsr
      601 qrptllpatg stpqpgssqq iqqrisvpps ptyppagppa fpagdskpel pltvairpfl
      661 adkgsrpqsp rkgpqtvnss siysmylqqa tppknyqpaa hsalnksvka vygkpvlpsg
      721 stspsplpfl hgslstgtpq pqppsestek epeqdgpaap adgstveslp rplsptkltp
      781 ivhsplryqs dadlealrrk lanaprplkk rssitepegp ggpniqklly qrfntlaggm
      841 egtpfyqpsp sqdfmgtlad vdngntnang nleelppaqp taplpaepap ssdandnelp
      901 spepeelicp qtthqtaepa ednnnnvatv ptteqipspv aeapspgeeq vppaplppas
      961 hppatstnkr tnlkkpnser tghglrvrfn plallldasl egefdlvqri iyevedpskp
     1021 ndegitplhn avcaghhhiv kflldfgvnv naadsdgwga gkagcdeqrc gvcsvglrgp
     1081 eq
//
LOCUS       XP_016876608             873 aa            linear   PRI 05-AUG-2025
DEFINITION  apoptosis-stimulating of p53 protein 1 isoform X7 [Homo sapiens].
ACCESSION   XP_016876608
VERSION     XP_016876608.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021119.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..873
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..873
                     /product="apoptosis-stimulating of p53 protein 1 isoform
                     X7"
                     /calculated_mol_wt=93871
     Region          <27..286
                     /region_name="PTZ00108"
                     /note="DNA topoisomerase 2-like protein; Provisional"
                     /db_xref="CDD:240271"
     Region          <228..646
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          675..761
                     /region_name="Ank_2"
                     /note="Ankyrin repeats (3 copies); pfam12796"
                     /db_xref="CDD:463710"
     Region          675..701
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(676..677,680..682,684..685,689,692,701,703,705,
                     709..710,713..715,717..718,722,725,734,736,738,742..743,
                     746..748,750..751,755,758)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          703..734
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          736..765
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          805..861
                     /region_name="SH3_ASPP1"
                     /note="Src Homology 3 domain of Apoptosis Stimulating of
                     p53 protein 1; cd11954"
                     /db_xref="CDD:212887"
     Site            order(813,816..817,819..820,838..839,841..842,853,855,857)
                     /site_type="other"
                     /note="p53 binding site [polypeptide binding]"
                     /db_xref="CDD:212887"
     CDS             1..873
                     /gene="PPP1R13B"
                     /gene_synonym="ASPP1; p53BP2-like; p85"
                     /coded_by="XM_017021119.2:76..2697"
                     /db_xref="GeneID:23368"
                     /db_xref="HGNC:HGNC:14950"
                     /db_xref="MIM:606455"
ORIGIN      
        1 mqrkymliga fwildfqirk dakqirnqln qeqnsklqqq kellnkrnme vammdkrise
       61 lrerlygkki qlnrvngtss pqsplstsgr vaavgpyiqv psagsfpvlg dpikpqslsi
      121 asnaahgrsk sdghskprvt sswtvsdldv gpnygssrps aspfvnpndg nwptlkqnss
      181 ssvkpvqvag adwkdpsveg svkqgtvssq pvpfsalgpt ekpgieigkv pppipgvgkq
      241 lppsygtyps ptplgpgsts slerrkegsl prpsaglpsr qrptllpatg stpqpgssqq
      301 iqqrisvpps ptyppagppa fpagdskpel pltvairpfl adkgsrpqsp rkgpqtvnss
      361 siysmylqqa tppknyqpaa hsalnksvka vygkpvlpsg stspsplpfl hgslstgtpq
      421 pqppsestek epeqdgpaap adgstveslp rplsptkltp ivhsplryqs dadlealrrk
      481 lanaprplkk rssitepegp ggpniqklly qrfntlaggm egtpfyqpsp sqdfmgtlad
      541 vdngntnang nleelppaqp taplpaepap ssdandnelp spepeelicp qtthqtaepa
      601 ednnnnvatv ptteqipspv aeapspgeeq vppaplppas hppatstnkr tnlkkpnser
      661 tghglrvrfn plallldasl egefdlvqri iyevedpskp ndegitplhn avcaghhhiv
      721 kflldfgvnv naadsdgwtp lhcaascnsv hlckqlvesg aaifastisd ietaadkcee
      781 meegyiqcsq flygvqeklg vmnkgvayal wdyeaqnsde lsfhegdalt ilrrkdeset
      841 ewwwarlgdr egyvpknllg lyprikprqr tla
//
LOCUS       XP_047287129            2497 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger FYVE domain-containing protein 26 isoform X1 [Homo
            sapiens].
ACCESSION   XP_047287129
VERSION     XP_047287129.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431173.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2497
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2497
                     /product="zinc finger FYVE domain-containing protein 26
                     isoform X1"
                     /calculated_mol_wt=279991
     Region          1809..1869
                     /region_name="FYVE_ZFY26"
                     /note="FYVE domain found in FYVE domain-containing protein
                     26 (ZFY26 or ZFYVE26); cd15724"
                     /db_xref="CDD:277263"
     Site            order(1809,1812,1831..1836,1838..1839,1862..1864)
                     /site_type="other"
                     /note="putative phosphatidylinositol 3-phosphate binding
                     site [chemical binding]"
                     /db_xref="CDD:277263"
     CDS             1..2497
                     /gene="ZFYVE26"
                     /gene_synonym="FYVE-CENT; SPG15"
                     /coded_by="XM_047431173.1:141..7634"
                     /db_xref="GeneID:23503"
                     /db_xref="HGNC:HGNC:20761"
                     /db_xref="MIM:612012"
ORIGIN      
        1 mnhpfgkeea asqkqlfgff ceclrrgewe laqacvpqlq egqgdipkrv edilqalvvc
       61 pnllrcgqdi npqrvawvwl lvlekwlare kkllpvvfrr kleflllsed lqgdipenil
      121 eelyetltqg avghvpdgnp rreswtprls seavsvlwdl lrqspqpaqa llellleedd
      181 gtglchwplq nalvdlirka lralqgpdsv ppgvvdaiyg alrtlrcpae plgvelhllc
      241 eelleacrte gsplreerll scllhkasrg llslyghtya ekvtekppra tasgkvspdh
      301 ldperamlal fsnpnpaeaw kvayfyclsn nkhfleqilv taltllkeed fpnlgclldr
      361 efrplscllv llgwthcqsl esakrllqtl hrtqgpgcde llrdacdglw ahlevlewci
      421 qqssnpipkr dllyhlhggd shsvlytlhh ltnlpalree dvlkllqkvp akdpqqepda
      481 vdapvpehls qcqnltlyqg fcamkyaiya lcvnshqhsq cqdckdslse dlasatepan
      541 dslsspgaan lfstylarcq qylcsipdsl clellenifs lllitsadlh pephlpedya
      601 edddiegksp sglrspsesp qhiahperks ergslgvpkt laytmpshvk aepkdsypgp
      661 hrhsfldlkh ftsgisgfla defaigaflr llqeqldeis srsppekpkq esqscsgsrd
      721 glqsrlhrls kvvseaqwrh kvvtsnhrse eqpsrryqpa trhpslrrgr rtrrsqadgr
      781 drgsnpsles tsselststs egslsamsgr nelhsrlhph pqsslipmmf sppesllasc
      841 ilrgnfaeah qvlftfnlks spssgelmfm eryqeviqel aqvehkienq nsdagsstir
      901 rtgsgrstlq aigsaaaagm vfysisdvtd kllntsgdpi pmlqedfwis talveptapl
      961 revledlspp amaafdlacs qcqlwktckq lletaerrln sslerrgrri dhvllnadgi
     1021 rgfpvvlqqi skslnyllms asqtksesve ekgggpprcs itellqmcwp slsedcvash
     1081 ttlsqqldqv lqslrealel peprtpplss lveqaaqkap eaeahpvqiq tqllqknlgk
     1141 qtpsgsrqmd ylgtffsycs tlaavllqsl ssepdhvevk vgnpfvllqq sssqlvshll
     1201 ferqvpperl aallaqenls lsvpqvivsc cceplalcss rqsqqtssll trlgtlaqlh
     1261 ashclddlpl stpssprtte nptlerkpys sprdsslpal tssalaflks rskllatvac
     1321 lgasprlkvs kpslswkelr grrevplaae qvarecerll eqfplfeafl laaweplrgs
     1381 lqqgqslavn lcgwaslstv llglhspial dvlseafees lvardwsral qltevygrdv
     1441 ddlssikdav lscavacdke gwqylfpvkd aslrsrlalq fvdrwplesc leilaycisd
     1501 tavqeglkce lqrklaelqv yqkilglqsp pvwcdwqtlr sccvedpstv mnmileaqey
     1561 elceewgcly piprehlisl hqkhllhlle rrdhdkalql lrripdptmc levteqsldq
     1621 htslatshfl anyltthfyg qltavrhrei qalyvgskil ltlpeqhras yshlssnplf
     1681 mleqllmnmk vdwatvavqt lqqllvgqei gftmdevdsl lsryaekald fpypqrekrs
     1741 dsvihlqeiv hqaadpetlp rspsaefspa appgissihs pslrersfpp tqpsqefvpp
     1801 atpparhqwv pdetesicmv ccrehftmfn rrhhcrrcgr lvcsscstkk mvvegcrenp
     1861 arvcdqcysy cnkdvpeeps ekpealdssk nesppysfvv rvpkadevew ildlkeeene
     1921 lvrsefyyeq apsaslciai lnlhrdsiac ghqliehccr lskgltnpev daglltdimk
     1981 qllfsakmmf vkagqsqdla lcdsyiskvd vlnilvaaay rhvpsldqil qpaavtrlrn
     2041 qlleaeyyql gvevstktgl dttgawhawg maclkagnlt aarekfsrcl kppfdlnqln
     2101 hgsrlvqdvv eylestvrpf vslqdddyfa tlreleatlr tqslslavip egkimnntyy
     2161 qeclfylhny stnlaiisfy vrhsclreal lhllnkespp evfiegifqp syksgklhtl
     2221 enllesidpt leswgkylia acqhlqkkny yhilyelqqf mkdqvraamt cirffshkak
     2281 sytelgekls wllkakdhlk iylqetsrss grkkttffrk kmtaadvsrh mntlqlqmev
     2341 trflhrcesa gtsqittlpl ptlfgnnhmk mdvackvmlg gknvedgfgi afrvlqdfql
     2401 daamtycraa rqlvekekys eiqqllkcvs esgmaaksdg dtillnclea fkrippqele
     2461 gliqaihndd nkivpilaal rdrvhteerg rspstlc
//
LOCUS       XP_047287131            1733 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger FYVE domain-containing protein 26 isoform X3 [Homo
            sapiens].
ACCESSION   XP_047287131
VERSION     XP_047287131.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431175.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1733
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1733
                     /product="zinc finger FYVE domain-containing protein 26
                     isoform X3"
                     /calculated_mol_wt=194292
     Region          1003..1063
                     /region_name="FYVE_ZFY26"
                     /note="FYVE domain found in FYVE domain-containing protein
                     26 (ZFY26 or ZFYVE26); cd15724"
                     /db_xref="CDD:277263"
     Site            order(1003,1006,1025..1030,1032..1033,1056..1058)
                     /site_type="other"
                     /note="putative phosphatidylinositol 3-phosphate binding
                     site [chemical binding]"
                     /db_xref="CDD:277263"
     CDS             1..1733
                     /gene="ZFYVE26"
                     /gene_synonym="FYVE-CENT; SPG15"
                     /coded_by="XM_047431175.1:108..5309"
                     /db_xref="GeneID:23503"
                     /db_xref="HGNC:HGNC:20761"
                     /db_xref="MIM:612012"
ORIGIN      
        1 msgrnelhsr lhphpqssli pmmfsppesl lascilrgnf aeahqvlftf nlksspssge
       61 lmfmeryqev iqelaqvehk ienqnsdags stirrtgsgr stlqaigsaa aagmvfysis
      121 dvtdkllnts gdpipmlqed fwistalvep taplrevled lsppamaafd lacsqcqlwk
      181 tckqlletae rrlnsslerr grridhvlln adgirgfpvv lqqiskslny llmsasqtks
      241 esveekgggp prcsitellq mcwpslsedc vashttlsqq ldqvlqslre alelpeprtp
      301 plsslveqaa qkapeaeahp vqiqtqllqk nlgkqtpsgs rqmdylgtff sycstlaavl
      361 lqslssepdh vevkvgnpfv llqqsssqlv shllferqvp perlaallaq enlslsvpqv
      421 ivscccepla lcssrqsqqt sslltrlgtl aqlhashcld dlplstpssp rttenptler
      481 kpyssprdss lpaltssala flksrsklla tvaclgaspr lkvskpslsw kelrgrrevp
      541 laaeqvarec erlleqfplf eafllaawep lrgslqqgqs lavnlcgwas lstvllglhs
      601 pialdvlsea feeslvardw sralqltevy grdvddlssi kdavlscava cdkegwqylf
      661 pvkdaslrsr lalqfvdrwp lescleilay cisdtavqeg lkcelqrkla elqvyqkilg
      721 lqsppvwcdw qtlrsccved pstvmnmile aqeyelceew gclypipreh lislhqkhll
      781 hllerrdhdk alqllrripd ptmclevteq sldqhtslat shflanyltt hfygqltavr
      841 hreiqalyvg skilltlpeq hrasyshlss nplfmleqll mnmkvdwatv avqtlqqllv
      901 gqeigftmde vdsllsryae kaldfpypqr ekrsdsvihl qeivhqaadp etlprspsae
      961 fspaappgis sihspslrer sfpptqpsqe fvppatppar hqwvpdetes icmvccrehf
     1021 tmfnrrhhcr rcgrlvcssc stkkmvvegc renparvcdq cysycnkdvp eepsekpeal
     1081 dssknesppy sfvvrvpkad evewildlke eenelvrsef yyeqapsasl ciailnlhrd
     1141 siacghqlie hccrlskglt npevdagllt dimkqllfsa kmmfvkagqs qdlalcdsyi
     1201 skvdvlnilv aaayrhvpsl dqilqpaavt rlrnqlleae yyqlgvevst ktgldttgaw
     1261 hawgmaclka gnltaarekf srclkppfdl nqlnhgsrlv qdvveylest vrpfvslqdd
     1321 dyfatlrele atlrtqslsl avipegkimn ntyyqeclfy lhnystnlai isfyvrhscl
     1381 reallhllnk esppevfieg ifqpsyksgk lhtlenlles idptleswgk yliaacqhlq
     1441 kknyyhilye lqqfmkdqvr aamtcirffs hkaksytelg eklswllkak dhlkiylqet
     1501 srssgrkktt ffrkkmtaad vsrhmntlql qmevtrflhr cesagtsqit tlplptlfgn
     1561 nhmkmdvack vmlggknved gfgiafrvlq dfqldaamty craarqlvek ekyseiqqll
     1621 kcvsesgmaa ksdgdtilln cleafkripp qelegliqai hnddnkvray liccklrsay
     1681 liavkqehsr atalvqqvqq aakssgdavv qdicaqwllt shprgahgpg srk
//
LOCUS       XP_011534911            1666 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger FYVE domain-containing protein 26 isoform X4 [Homo
            sapiens].
ACCESSION   XP_011534911
VERSION     XP_011534911.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536609.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1666
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1666
                     /product="zinc finger FYVE domain-containing protein 26
                     isoform X4"
                     /calculated_mol_wt=185738
     CDS             1..1666
                     /gene="ZFYVE26"
                     /gene_synonym="FYVE-CENT; SPG15"
                     /coded_by="XM_011536609.3:141..5141"
                     /db_xref="GeneID:23503"
                     /db_xref="HGNC:HGNC:20761"
                     /db_xref="MIM:612012"
ORIGIN      
        1 mnhpfgkeea asqkqlfgff ceclrrgewe laqacvpqlq egqgdipkrv edilqalvvc
       61 pnllrcgqdi npqrvawvwl lvlekwlare kkllpvvfrr kleflllsed lqgdipenil
      121 eelyetltqg avghvpdgnp rreswtprls seavsvlwdl lrqspqpaqa llellleedd
      181 gtglchwplq nalvdlirka lralqgpdsv ppgvvdaiyg alrtlrcpae plgvelhllc
      241 eelleacrte gsplreerll scllhkasrg llslyghtya ekvtekppra tasgkvspdh
      301 ldperamlal fsnpnpaeaw kvayfyclsn nkhfleqilv taltllkeed fpnlgclldr
      361 efrplscllv llgwthcqsl esakrllqtl hrtqgpgcde llrdacdglw ahlevlewci
      421 qqssnpipkr dllyhlhggd shsvlytlhh ltnlpalree dvlkllqkvp akdpqqepda
      481 vdapvpehls qcqnltlyqg fcamkyaiya lcvnshqhsq cqdckdslse dlasatepan
      541 dslsspgaan lfstylarcq qylcsipdsl clellenifs lllitsadlh pephlpedya
      601 edddiegksp sglrspsesp qhiahperks ergslgvpkt laytmpshvk aepkdsypgp
      661 hrhsfldlkh ftsgisgfla defaigaflr llqeqldeis srsppekpkq esqscsgsrd
      721 glqsrlhrls kvvseaqwrh kvvtsnhrse eqpsrryqpa trhpslrrgr rtrrsqadgr
      781 drgsnpsles tsselststs egslsamsgr nelhsrlhph pqsslipmmf sppesllasc
      841 ilrgnfaeah qvlftfnlks spssgelmfm eryqeviqel aqvehkienq nsdagsstir
      901 rtgsgrstlq aigsaaaagm vfysisdvtd kllntsgdpi pmlqedfwis talveptapl
      961 revledlspp amaafdlacs qcqlwktckq lletaerrln sslerrgrri dhvllnadgi
     1021 rgfpvvlqqi skslnyllms asqtksesve ekgggpprcs itellqmcwp slsedcvash
     1081 ttlsqqldqv lqslrealel peprtpplss lveqaaqkap eaeahpvqiq tqllqknlgk
     1141 qtpsgsrqmd ylgtffsycs tlaavllqsl ssepdhvevk vgnpfvllqq sssqlvshll
     1201 ferqvpperl aallaqenls lsvpqvivsc cceplalcss rqsqqtssll trlgtlaqlh
     1261 ashclddlpl stpssprtte nptlerkpys sprdsslpal tssalaflks rskllatvac
     1321 lgasprlkvs kpslswkelr grrevplaae qvarecerll eqfplfeafl laaweplrgs
     1381 lqqgqslavn lcgwaslstv llglhspial dvlseafees lvardwsral qltevygrdv
     1441 ddlssikdav lscavacdke gwqylfpvkd aslrsrlalq fvdrwplesc leilaycisd
     1501 tavqeglkce lqrklaelqv yqkilglqsp pvwcdwqtlr sccvedpstv mnmileaqey
     1561 elceewgcly piprehlisl hqkhllhlle rrdhdkalql lrripdptmc levteqsldq
     1621 htslatshfl anyltthfyg qltavrhrei qalyvgskiy ptnrfc
//
LOCUS       XP_006720157             368 aa            linear   PRI 05-AUG-2025
DEFINITION  kelch domain-containing protein 2 isoform X1 [Homo sapiens].
ACCESSION   XP_006720157
VERSION     XP_006720157.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720094.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..368
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..368
                     /product="kelch domain-containing protein 2 isoform X1"
                     /calculated_mol_wt=41815
     Region          32..91
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          32..89
                     /region_name="Kelch_4"
                     /note="Galactose oxidase, central domain; pfam13418"
                     /db_xref="CDD:433191"
     Region          78..>337
                     /region_name="NanM"
                     /note="N-acetylneuraminic acid mutarotase [Cell
                     wall/membrane/envelope biogenesis]; COG3055"
                     /db_xref="CDD:442289"
     Region          92..138
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          218..265
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     CDS             1..368
                     /gene="KLHDC2"
                     /gene_synonym="HCLP-1; HCLP1; LCP"
                     /coded_by="XM_006720094.5:317..1423"
                     /db_xref="GeneID:23588"
                     /db_xref="HGNC:HGNC:20231"
                     /db_xref="MIM:611280"
ORIGIN      
        1 madgnedlra ddlpgpafes yesmelacpa ersghvavsd grhmfvwggy ksnqvrglyd
       61 fylpreelwi ynmetgrwkk integdvpps msgscavcvd rvlylfgghh srgntnkfym
      121 ldsrstdrvl qweridcqgi ppsskdklgv wvyknkliff ggygylpedk vlgtfefdet
      181 sfwnsshprg wndhvhildt etftwsqpit tgkapspraa hacatvgnrg fvfggryrda
      241 rmndlhylnl dtwewnelip qgicpvgrsw hsltpvssdh lflfggfttd kqplsdawty
      301 cisknewiqf nhpytekprl whtacasdeg evivfggcan nllvhhraah sneilifsvq
      361 pkslvryi
//
LOCUS       XP_011534912             334 aa            linear   PRI 05-AUG-2025
DEFINITION  kelch domain-containing protein 2 isoform X2 [Homo sapiens].
ACCESSION   XP_011534912
VERSION     XP_011534912.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536610.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..334
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..334
                     /product="kelch domain-containing protein 2 isoform X2"
                     /calculated_mol_wt=37755
     Region          6..269
                     /region_name="NanM"
                     /note="N-acetylneuraminic acid mutarotase [Cell
                     wall/membrane/envelope biogenesis]; COG3055"
                     /db_xref="CDD:442289"
     Region          20..66
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          146..193
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     CDS             1..334
                     /gene="KLHDC2"
                     /gene_synonym="HCLP-1; HCLP1; LCP"
                     /coded_by="XM_011536610.2:346..1350"
                     /db_xref="GeneID:23588"
                     /db_xref="HGNC:HGNC:20231"
                     /db_xref="MIM:611280"
ORIGIN      
        1 metgrwkkin tegdvppsms gscavcvdrv lylfgghhsr gntnkfymld srstdrvlqw
       61 eridcqgipp sskdklgvwv yknkliffgg ygylpedkvl gtfefdetsf wnsshprgwn
      121 dhvhildtet ftwsqpittg kapspraaha catvgnrgfv fggryrdarm ndlhylnldt
      181 wewnelipqg icpvgrswhs ltpvssdhlf lfggfttdkq plsdawtyci sknewiqfnh
      241 pytekprlwh tacasdegev ivfggcannl lvhhraahsn eilifsvqpk slvrlsleav
      301 icfkemlans wnclpkhllh svnqrfgsnn tsgs
//
LOCUS       XP_047287132             660 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat transmembrane protein FLRT2 isoform X1 [Homo
            sapiens].
ACCESSION   XP_047287132
VERSION     XP_047287132.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431176.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..660
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..660
                     /product="leucine-rich repeat transmembrane protein FLRT2
                     isoform X1"
                     /calculated_mol_wt=73918
     Region          35..62
                     /region_name="LRRNT"
                     /note="Leucine rich repeat N-terminal domain; pfam01462"
                     /db_xref="CDD:396168"
     Region          50..>310
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          65..86
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          90..110
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          111..134
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          135..160
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          161..181
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          182..205
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          206..231
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          232..253
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          254..277
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          278..301
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          282..>359
                     /region_name="PCC"
                     /note="polycystin cation channel protein; TIGR00864"
                     /db_xref="CDD:188093"
     Region          426..494
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     CDS             1..660
                     /gene="FLRT2"
                     /coded_by="XM_047431176.1:1385..3367"
                     /db_xref="GeneID:23768"
                     /db_xref="HGNC:HGNC:3761"
                     /db_xref="MIM:604807"
ORIGIN      
        1 mglqttkwps hgafflkswl iislglysqv skllacpsvc rcdrnfvycn ersltsvplg
       61 ipegvtvlyl hnnqinnagf paelhnvqsv htvylygnql defpmnlpkn vrvlhlqenn
      121 iqtisraala qllkleelhl ddnsistvgv edgafreais lkllflsknh lssvpvglpv
      181 dlqelrvden riavisdmaf qnltslerli vdgnlltnkg iaegtfshlt klkefsivrn
      241 slshpppdlp gthlirlylq dnqinhiplt afsnlrkler ldisnnqlrm ltqgvfdnls
      301 nlkqltarnn pwfcdcsikw vtewlkyips slnvrgfmcq gpeqvrgmav relnmnllsc
      361 ptttpglplf tpapstaspt tqpptlsipn psrsytpptp ttsklptipd wdgrervtpp
      421 iseriqlsih fvndtsiqvs wlslftvmay kltwvkmghs lvggivqeri vsgekqhlsl
      481 vnleprstyr iclvpldafn yravedtics eatthasyln ngsntasshe qttshsmgsp
      541 fllagligga vifvlvvlls vfcwhmhkkg rytsqkwkyn rgrrkddyce agtkkdnsil
      601 emtetsfqiv slnndqllkg dfrlqpiytp ngginytdch ipnnmrycns svpdlehcht
//
LOCUS       XP_047287133             609 aa            linear   PRI 05-AUG-2025
DEFINITION  alpha-(1,6)-fucosyltransferase isoform X1 [Homo sapiens].
ACCESSION   XP_047287133
VERSION     XP_047287133.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431177.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..609
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..609
                     /product="alpha-(1,6)-fucosyltransferase isoform X1"
                     /calculated_mol_wt=70261
     Region          68..532
                     /region_name="FUT8_N_cat"
                     /note="Alpha-(1,6)-fucosyltransferase N- and catalytic
                     domains; pfam19745"
                     /db_xref="CDD:466170"
     Region          540..594
                     /region_name="SH3_Fut8"
                     /note="Src homology 3 domain of
                     Alpha1,6-fucosyltransferase (Fut8); cd11792"
                     /db_xref="CDD:212726"
     Site            order(545,547,550,554,572..573,588,590..591)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212726"
     CDS             1..609
                     /gene="FUT8"
                     /gene_synonym="CDGF; CDGF1"
                     /coded_by="XM_047431177.1:1792..3621"
                     /db_xref="GeneID:2530"
                     /db_xref="HGNC:HGNC:4019"
                     /db_xref="MIM:602589"
ORIGIN      
        1 mrpwtgswrw imlilfawgt llfyigghlv rdndhpdhss relskilakl erlkqqnedl
       61 rrmaeslrip egpidqgpai grvrvleeql vkakeqieny kkqtrnglgk dheilrrrie
      121 ngakelwffl qselkklknl egnelqrhad eflldlghhe rilmaitvsl vnnkrkivvl
      181 aqpttvkrkr itpyksimtd lyylsqtdga gdwrekeakd ltelvqrrit ylqnpkdcsk
      241 akklvcnink gcgygcqlhh vvycfmiayg tqrtlilesq nwryatggwe tvfrpvsetc
      301 tdrsgistgh wsgevkdknv qvvelpivds lhprppylpl avpedladrl vrvhgdpavw
      361 wvsqfvkyli rpqpwlekei eeatkklgfk hpvigvhvrr tdkvgteaaf hpieeymvhv
      421 eehfqllarr mqvdkkrvyl atddpsllke aktkypnyef isdnsiswsa glhnrytens
      481 lrgvildihf lsqadflvct fssqvcrvay eimqtlhpda sanfhslddi yyfggqnahn
      541 qiaiyahqpr tadeipmepg diigvagnhw dgyskgvnrk lgrtglypsy kvrekietvk
      601 yptypeaek
//
LOCUS       XP_047287134             609 aa            linear   PRI 05-AUG-2025
DEFINITION  alpha-(1,6)-fucosyltransferase isoform X1 [Homo sapiens].
ACCESSION   XP_047287134
VERSION     XP_047287134.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431178.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..609
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..609
                     /product="alpha-(1,6)-fucosyltransferase isoform X1"
                     /calculated_mol_wt=70261
     Region          68..532
                     /region_name="FUT8_N_cat"
                     /note="Alpha-(1,6)-fucosyltransferase N- and catalytic
                     domains; pfam19745"
                     /db_xref="CDD:466170"
     Region          540..594
                     /region_name="SH3_Fut8"
                     /note="Src homology 3 domain of
                     Alpha1,6-fucosyltransferase (Fut8); cd11792"
                     /db_xref="CDD:212726"
     Site            order(545,547,550,554,572..573,588,590..591)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212726"
     CDS             1..609
                     /gene="FUT8"
                     /gene_synonym="CDGF; CDGF1"
                     /coded_by="XM_047431178.1:2200..4029"
                     /db_xref="GeneID:2530"
                     /db_xref="HGNC:HGNC:4019"
                     /db_xref="MIM:602589"
ORIGIN      
        1 mrpwtgswrw imlilfawgt llfyigghlv rdndhpdhss relskilakl erlkqqnedl
       61 rrmaeslrip egpidqgpai grvrvleeql vkakeqieny kkqtrnglgk dheilrrrie
      121 ngakelwffl qselkklknl egnelqrhad eflldlghhe rilmaitvsl vnnkrkivvl
      181 aqpttvkrkr itpyksimtd lyylsqtdga gdwrekeakd ltelvqrrit ylqnpkdcsk
      241 akklvcnink gcgygcqlhh vvycfmiayg tqrtlilesq nwryatggwe tvfrpvsetc
      301 tdrsgistgh wsgevkdknv qvvelpivds lhprppylpl avpedladrl vrvhgdpavw
      361 wvsqfvkyli rpqpwlekei eeatkklgfk hpvigvhvrr tdkvgteaaf hpieeymvhv
      421 eehfqllarr mqvdkkrvyl atddpsllke aktkypnyef isdnsiswsa glhnrytens
      481 lrgvildihf lsqadflvct fssqvcrvay eimqtlhpda sanfhslddi yyfggqnahn
      541 qiaiyahqpr tadeipmepg diigvagnhw dgyskgvnrk lgrtglypsy kvrekietvk
      601 yptypeaek
//
LOCUS       XP_047287135             609 aa            linear   PRI 05-AUG-2025
DEFINITION  alpha-(1,6)-fucosyltransferase isoform X1 [Homo sapiens].
ACCESSION   XP_047287135
VERSION     XP_047287135.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431179.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..609
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..609
                     /product="alpha-(1,6)-fucosyltransferase isoform X1"
                     /calculated_mol_wt=70261
     Region          68..532
                     /region_name="FUT8_N_cat"
                     /note="Alpha-(1,6)-fucosyltransferase N- and catalytic
                     domains; pfam19745"
                     /db_xref="CDD:466170"
     Region          540..594
                     /region_name="SH3_Fut8"
                     /note="Src homology 3 domain of
                     Alpha1,6-fucosyltransferase (Fut8); cd11792"
                     /db_xref="CDD:212726"
     Site            order(545,547,550,554,572..573,588,590..591)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212726"
     CDS             1..609
                     /gene="FUT8"
                     /gene_synonym="CDGF; CDGF1"
                     /coded_by="XM_047431179.1:791..2620"
                     /db_xref="GeneID:2530"
                     /db_xref="HGNC:HGNC:4019"
                     /db_xref="MIM:602589"
ORIGIN      
        1 mrpwtgswrw imlilfawgt llfyigghlv rdndhpdhss relskilakl erlkqqnedl
       61 rrmaeslrip egpidqgpai grvrvleeql vkakeqieny kkqtrnglgk dheilrrrie
      121 ngakelwffl qselkklknl egnelqrhad eflldlghhe rilmaitvsl vnnkrkivvl
      181 aqpttvkrkr itpyksimtd lyylsqtdga gdwrekeakd ltelvqrrit ylqnpkdcsk
      241 akklvcnink gcgygcqlhh vvycfmiayg tqrtlilesq nwryatggwe tvfrpvsetc
      301 tdrsgistgh wsgevkdknv qvvelpivds lhprppylpl avpedladrl vrvhgdpavw
      361 wvsqfvkyli rpqpwlekei eeatkklgfk hpvigvhvrr tdkvgteaaf hpieeymvhv
      421 eehfqllarr mqvdkkrvyl atddpsllke aktkypnyef isdnsiswsa glhnrytens
      481 lrgvildihf lsqadflvct fssqvcrvay eimqtlhpda sanfhslddi yyfggqnahn
      541 qiaiyahqpr tadeipmepg diigvagnhw dgyskgvnrk lgrtglypsy kvrekietvk
      601 yptypeaek
//
LOCUS       XP_016876627             609 aa            linear   PRI 05-AUG-2025
DEFINITION  alpha-(1,6)-fucosyltransferase isoform X1 [Homo sapiens].
ACCESSION   XP_016876627
VERSION     XP_016876627.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021138.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..609
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..609
                     /product="alpha-(1,6)-fucosyltransferase isoform X1"
                     /calculated_mol_wt=70261
     Region          68..532
                     /region_name="FUT8_N_cat"
                     /note="Alpha-(1,6)-fucosyltransferase N- and catalytic
                     domains; pfam19745"
                     /db_xref="CDD:466170"
     Region          540..594
                     /region_name="SH3_Fut8"
                     /note="Src homology 3 domain of
                     Alpha1,6-fucosyltransferase (Fut8); cd11792"
                     /db_xref="CDD:212726"
     Site            order(545,547,550,554,572..573,588,590..591)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212726"
     CDS             1..609
                     /gene="FUT8"
                     /gene_synonym="CDGF; CDGF1"
                     /coded_by="XM_017021138.2:1630..3459"
                     /db_xref="GeneID:2530"
                     /db_xref="HGNC:HGNC:4019"
                     /db_xref="MIM:602589"
ORIGIN      
        1 mrpwtgswrw imlilfawgt llfyigghlv rdndhpdhss relskilakl erlkqqnedl
       61 rrmaeslrip egpidqgpai grvrvleeql vkakeqieny kkqtrnglgk dheilrrrie
      121 ngakelwffl qselkklknl egnelqrhad eflldlghhe rilmaitvsl vnnkrkivvl
      181 aqpttvkrkr itpyksimtd lyylsqtdga gdwrekeakd ltelvqrrit ylqnpkdcsk
      241 akklvcnink gcgygcqlhh vvycfmiayg tqrtlilesq nwryatggwe tvfrpvsetc
      301 tdrsgistgh wsgevkdknv qvvelpivds lhprppylpl avpedladrl vrvhgdpavw
      361 wvsqfvkyli rpqpwlekei eeatkklgfk hpvigvhvrr tdkvgteaaf hpieeymvhv
      421 eehfqllarr mqvdkkrvyl atddpsllke aktkypnyef isdnsiswsa glhnrytens
      481 lrgvildihf lsqadflvct fssqvcrvay eimqtlhpda sanfhslddi yyfggqnahn
      541 qiaiyahqpr tadeipmepg diigvagnhw dgyskgvnrk lgrtglypsy kvrekietvk
      601 yptypeaek
//
LOCUS       XP_047287136             609 aa            linear   PRI 05-AUG-2025
DEFINITION  alpha-(1,6)-fucosyltransferase isoform X1 [Homo sapiens].
ACCESSION   XP_047287136
VERSION     XP_047287136.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431180.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..609
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..609
                     /product="alpha-(1,6)-fucosyltransferase isoform X1"
                     /calculated_mol_wt=70261
     Region          68..532
                     /region_name="FUT8_N_cat"
                     /note="Alpha-(1,6)-fucosyltransferase N- and catalytic
                     domains; pfam19745"
                     /db_xref="CDD:466170"
     Region          540..594
                     /region_name="SH3_Fut8"
                     /note="Src homology 3 domain of
                     Alpha1,6-fucosyltransferase (Fut8); cd11792"
                     /db_xref="CDD:212726"
     Site            order(545,547,550,554,572..573,588,590..591)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212726"
     CDS             1..609
                     /gene="FUT8"
                     /gene_synonym="CDGF; CDGF1"
                     /coded_by="XM_047431180.1:11603..13432"
                     /db_xref="GeneID:2530"
                     /db_xref="HGNC:HGNC:4019"
                     /db_xref="MIM:602589"
ORIGIN      
        1 mrpwtgswrw imlilfawgt llfyigghlv rdndhpdhss relskilakl erlkqqnedl
       61 rrmaeslrip egpidqgpai grvrvleeql vkakeqieny kkqtrnglgk dheilrrrie
      121 ngakelwffl qselkklknl egnelqrhad eflldlghhe rilmaitvsl vnnkrkivvl
      181 aqpttvkrkr itpyksimtd lyylsqtdga gdwrekeakd ltelvqrrit ylqnpkdcsk
      241 akklvcnink gcgygcqlhh vvycfmiayg tqrtlilesq nwryatggwe tvfrpvsetc
      301 tdrsgistgh wsgevkdknv qvvelpivds lhprppylpl avpedladrl vrvhgdpavw
      361 wvsqfvkyli rpqpwlekei eeatkklgfk hpvigvhvrr tdkvgteaaf hpieeymvhv
      421 eehfqllarr mqvdkkrvyl atddpsllke aktkypnyef isdnsiswsa glhnrytens
      481 lrgvildihf lsqadflvct fssqvcrvay eimqtlhpda sanfhslddi yyfggqnahn
      541 qiaiyahqpr tadeipmepg diigvagnhw dgyskgvnrk lgrtglypsy kvrekietvk
      601 yptypeaek
//
LOCUS       XP_047287137             575 aa            linear   PRI 05-AUG-2025
DEFINITION  alpha-(1,6)-fucosyltransferase isoform X2 [Homo sapiens].
ACCESSION   XP_047287137
VERSION     XP_047287137.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431181.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..575
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..575
                     /product="alpha-(1,6)-fucosyltransferase isoform X2"
                     /calculated_mol_wt=66385
     Region          68..498
                     /region_name="FUT8_N_cat"
                     /note="Alpha-(1,6)-fucosyltransferase N- and catalytic
                     domains; pfam19745"
                     /db_xref="CDD:466170"
     Region          506..560
                     /region_name="SH3_Fut8"
                     /note="Src homology 3 domain of
                     Alpha1,6-fucosyltransferase (Fut8); cd11792"
                     /db_xref="CDD:212726"
     Site            order(511,513,516,520,538..539,554,556..557)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212726"
     CDS             1..575
                     /gene="FUT8"
                     /gene_synonym="CDGF; CDGF1"
                     /coded_by="XM_047431181.1:1792..3519"
                     /db_xref="GeneID:2530"
                     /db_xref="HGNC:HGNC:4019"
                     /db_xref="MIM:602589"
ORIGIN      
        1 mrpwtgswrw imlilfawgt llfyigghlv rdndhpdhss relskilakl erlkqqnedl
       61 rrmaeslrip egpidqgpai grvrvleeql vkakeqieny kkqtrnglgk dheilrrrie
      121 ngakelwffl qselkklknl egnelqrhad eflldlghhe rsimtdlyyl sqtdgagdwr
      181 ekeakdltel vqrritylqn pkdcskakkl vcninkgcgy gcqlhhvvyc fmiaygtqrt
      241 lilesqnwry atggwetvfr pvsetctdrs gistghwsge vkdknvqvve lpivdslhpr
      301 ppylplavpe dladrlvrvh gdpavwwvsq fvkylirpqp wlekeieeat kklgfkhpvi
      361 gvhvrrtdkv gteaafhpie eymvhveehf qllarrmqvd kkrvylatdd psllkeaktk
      421 ypnyefisdn siswsaglhn rytenslrgv ildihflsqa dflvctfssq vcrvayeimq
      481 tlhpdasanf hslddiyyfg gqnahnqiai yahqprtade ipmepgdiig vagnhwdgys
      541 kgvnrklgrt glypsykvre kietvkypty peaek
//
LOCUS       XP_006720161            2590 aa            linear   PRI 05-AUG-2025
DEFINITION  ral GTPase-activating protein subunit alpha-1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_006720161
VERSION     XP_006720161.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720098.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2590
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2590
                     /product="ral GTPase-activating protein subunit alpha-1
                     isoform X1"
                     /calculated_mol_wt=290303
     Region          550..678
                     /region_name="RALGAPB_N"
                     /note="RALGAPB N-terminal domain; pfam20412"
                     /db_xref="CDD:466561"
     Region          2332..2505
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     CDS             1..2590
                     /gene="RALGAPA1"
                     /gene_synonym="GARNL1; GRIPE; NEDHRIT; p240; RalGAPalpha1;
                     TULIP1"
                     /coded_by="XM_006720098.4:461..8233"
                     /db_xref="GeneID:253959"
                     /db_xref="HGNC:HGNC:17770"
                     /db_xref="MIM:608884"
ORIGIN      
        1 mfskkphgdv kkstqkvldt kkdaltrlkh lrivienaes idlkqffdqh fshiyyvffe
       61 nfvtieaslk qkghksqree ldailfifek ilqllperih qrwqfhsigl ilkkllhtgn
      121 slkirregvr lfllwlqalq nncskeqlwm fsclipgfsa pqsehgprtl dnlinpplnl
      181 qetqvtieei tplvppqsgd kgqedltsyf leallkyivi qvkslewknk enqergfsfl
      241 fshfkkyylp yifpnicken slyhpildip qmrpkphyvv ikkdaetnea iyctkepfik
      301 arvivirwlv sfwlepkpht gphipgmege vlpkniqraa aslvsreesk ndnadktdrt
      361 tepeqshsnt stlterepss sslcsideeh ltdieivrrv fsskrsnvnf vteifrqafl
      421 lpiceaaamr kvvkvyqewi qqeekplfmq epeeivitss dlpcienvtd hdismeegek
      481 reeengtnta dhvrnsswak ngsyqgalhn aseeateqni ragtqavlqv fiinssnifl
      541 lepaneiknl ldehtdmckr ilniyrymvv qvsmdkktwe qmllvllrvt esvlkmpsqa
      601 flqfqgkknm tlagrlagpl fqtlivawik anlnvyisre lwddllsvls sltyweelat
      661 ewsltmetlt kvlarnlysl dlsdlpldkl seqkqkkhkg kgvghefqkv svdksfsrgw
      721 srdqpgqapm rqrsatttgs pgtekarsiv rqktvamrsr sigecalpsa yirsaksapv
      781 lihtskpflp divltplsde lsdiddaqil prstrvrhfs qseetgnevf galneeqplp
      841 rssstsdile pftverakga vpvidsssrh apslqsstea ssitrstesh itdthsress
      901 levgdsiydh lchligpvel adsafeqiqy idlegdddll stlkeyfken qenhsknetg
      961 kdpasqevti avnrgerlsl dklectdqet esenitsfvg tpenlqfqke pnsavfmsni
     1021 apnqsdsffr tqtsekskql ntdkqpseps ldspcdkekr khlyrqaate ldacvdvtlv
     1081 eklksvqine kitvphvmra kkatlkapvn rrmphvtsts klsptkrsls etvthrakim
     1141 kiatkkrnsv hvtfrpstes vqfynplenk eapwkmrlrk lggfssgssn sstsnthtst
     1201 nsatelvkpg vyrpldtlgt asvssktvke steipttilq kegiassqlg srstlrsssh
     1261 eaglqqgslg gvyktvvhal skpkanvspq rqnrmppeap lrdlyshvmg yfgrkaavnk
     1321 edmsqklppl nsdiggssan vpdlmdefia erlrsgnast mtrrgsspgs leipkdlpdi
     1381 lnkqnqmrpi ddpgvpsewt spasagssdl issdshsdsf safqydgrkf dnfgfgtdtg
     1441 vtssadvdsg sghhqsaeeq evaslttlhi dsetsslnqq afsaevatit gsesaspvhs
     1501 plgsrsqtps pstlnidhme qkdlqldekl hhsvlqtpdd leisefpsec csvmaggtlt
     1561 gwhadvatvm wrrmlgilgd vnsimdpeih aqvfdylcel wqnlakirdn lgistdnlts
     1621 psppvlippl riltpwlfka tmltdkykqg klhayklicn tmkrrqdvsp nrdflthfyn
     1681 imhcgllhid qdivntiikh cspqffslgl pgatmlimdf ivaagrvass aflnaprvea
     1741 qvllgslvcf pnlycelpsl hpnipdvavs qftdvkelii ktvlssarde psgparcval
     1801 cslgiwicee lvheshhpqi kealnvicvs lkftnktvah vacnmlhmlv hyvprlqiyq
     1861 pdsplkiiqi liatithllp steassyemd krlvvslllc lldwimalpl ktllqpfhat
     1921 gaesdkteks vlnciykvlh gcvygaqcfs npryfpmsls dlasvdydpf mhleslkepe
     1981 plhspdsers sklqpvtevk tqmqhglisi aartvithlv nhlghypmsg gpamltsqvc
     2041 enhdnhyses telspelfes pniqffvlnn ttlvsciqir seenmpgggl saglasansn
     2101 vriivrdlsg kyswdsaily gpppvsglse ptsfmlslsh qekpeeppts necleditvk
     2161 dglslqfkrf retvptwdti rdeedvldel lqylgvtspe clqrtgisln ipapqpvcis
     2221 ekqendvina ilkqhteeke fvekhfndln mkaveqdepi pqkpqsafyy crlllsilgm
     2281 nswdkrrsfh llkknekllr elrnldsrqc rethkiavfy vaegqedkhs iltntggsqa
     2341 yedfvaglgw evnltnhcgf mgglqknkst glttpyfats tvevifhvst rmpsdsddsl
     2401 tkklrhlgnd evhivwseht rdyrrgiipt efgdvliviy pmknhmfsiq imkkpevpff
     2461 gplfdgaivn gkvlpimvra tainasralk sliplyqnfy eerarylqti vqhhlepttf
     2521 edfaaqvfsp apyhhlpsda vgsypeilps etptatqvdg adlaspmspr tsksrmsmkl
     2581 rrssgsanks
//
LOCUS       XP_006720162            2589 aa            linear   PRI 05-AUG-2025
DEFINITION  ral GTPase-activating protein subunit alpha-1 isoform X2 [Homo
            sapiens].
ACCESSION   XP_006720162
VERSION     XP_006720162.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720099.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2589
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2589
                     /product="ral GTPase-activating protein subunit alpha-1
                     isoform X2"
                     /calculated_mol_wt=290204
     Region          550..678
                     /region_name="RALGAPB_N"
                     /note="RALGAPB N-terminal domain; pfam20412"
                     /db_xref="CDD:466561"
     Region          2332..2505
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     CDS             1..2589
                     /gene="RALGAPA1"
                     /gene_synonym="GARNL1; GRIPE; NEDHRIT; p240; RalGAPalpha1;
                     TULIP1"
                     /coded_by="XM_006720099.4:461..8230"
                     /db_xref="GeneID:253959"
                     /db_xref="HGNC:HGNC:17770"
                     /db_xref="MIM:608884"
ORIGIN      
        1 mfskkphgdv kkstqkvldt kkdaltrlkh lrivienaes idlkqffdqh fshiyyvffe
       61 nfvtieaslk qkghksqree ldailfifek ilqllperih qrwqfhsigl ilkkllhtgn
      121 slkirregvr lfllwlqalq nncskeqlwm fsclipgfsa pqsehgprtl dnlinpplnl
      181 qetqvtieei tplvppqsgd kgqedltsyf leallkyivi qvkslewknk enqergfsfl
      241 fshfkkyylp yifpnicken slyhpildip qmrpkphyvv ikkdaetnea iyctkepfik
      301 arvivirwlv sfwlepkpht gphipgmege vlpkniqraa aslvsreesk ndnadktdrt
      361 tepeqshsnt stlterepss sslcsideeh ltdieivrrv fsskrsnvnf vteifrqafl
      421 lpiceaaamr kvvkvyqewi qqeekplfmq epeeivitss dlpcienvtd hdismeegek
      481 reeengtnta dhvrnsswak ngsyqgalhn aseeateqni ragtqavlqv fiinssnifl
      541 lepaneiknl ldehtdmckr ilniyrymvv qvsmdkktwe qmllvllrvt esvlkmpsqa
      601 flqfqgkknm tlagrlagpl fqtlivawik anlnvyisre lwddllsvls sltyweelat
      661 ewsltmetlt kvlarnlysl dlsdlpldkl seqkqkkhkg kgvghefqkv svdksfsrgw
      721 srdqpgqapm rqrsatttgs pgtekarsiv rqktvamrsr sigecalpsa yirsaksapv
      781 lihtskpflp divltplsde lsdiddaqil prstrvrhfs qseetgnevf galneeqplp
      841 rssstsdile pftverakga vpvidsssrh apslqsstea ssitrstesh itdthsress
      901 levgdsiydh lchligpvel adsafeqiqy idlegdddll stlkeyfken qenhsknetg
      961 kdpasqevti avnrgerlsl dklectdqet esenitsfvg tpenlqfqke pnsavfmsni
     1021 apnqsdsffr tqtsekskql ntdkqpseps ldspcdkekr khlyrqaate ldacvdvtlv
     1081 eklksvqine kitvphvmra kkatlkapvn rrmphvtsts klsptkrsls etvthrakim
     1141 kiatkkrnsv hvtfrpstes vqfynplenk eapwkmrlrk lggfssgssn sstsnthtst
     1201 nsatelvkpg vyrpldtlgt asvssktvke steipttilq kegiassqlg srstlrsssh
     1261 eaglqqgslg gvyktvvhal skpkanvspq rqnrmppeap lrdlyshvmg yfgrkaavnk
     1321 edmsqklppl nsdiggssan vpdlmdefia erlrsgnast mtrrgsspgs leipkdlpdi
     1381 lnkqnqmrpi ddpgvpsewt spasagssdl issdshsdsf safqydgrkf dnfgfgtdtg
     1441 vtssadvdsg sghhqsaeeq evaslttlhi dsetsslnqq afsaevatit gsesaspvhs
     1501 plgsrsqtps pstlnidhme qkdlqldekl hhsvlqtpdd leisefpsec csvmaggtlt
     1561 gwhadvatvm wrrmlgilgd vnsimdpeih aqvfdylcel wqnlakirdn lgistdnlts
     1621 psppvlippl riltpwlfka tmltdkykqg klhayklicn tmkrrqdvsp nrdflthfyn
     1681 imhcgllhid qdivntiikh cspqffslgl pgatmlimdf ivaagrvass aflnaprvea
     1741 qvllgslvcf pnlycelpsl hpnipdvavs qftdvkelii ktvlssarde psgparcval
     1801 cslgiwicee lvheshhpqi kealnvicvs lkftnktvah vacnmlhmlv hyvprlqiyq
     1861 pdsplkiiqi liatithllp steassyemd krlvvslllc lldwimalpl ktllqpfhat
     1921 gaesdkteks vlnciykvlh gcvygaqcfs npryfpmsls dlasvdydpf mhleslkepe
     1981 plhspdsers sklqpvtevk tqmqhglisi aartvithlv nhlghypmsg gpamltsqvc
     2041 enhdnhyses telspelfes pniqffvlnn ttlvsciqir seenmpgggl saglasansn
     2101 vriivrdlsg kyswdsaily gpppvsglse ptsfmlslsh qekpeeppts necleditvk
     2161 dglslqfkrf retvptwdti rdeedvldel lqylgvtspe clqrtgisln ipapqpvcis
     2221 ekqendvina ilkqhteeke fvekhfndln mkaveqdepi pqkpqsafyy crlllsilgm
     2281 nswdkrrsfh llkknekllr elrnldsrqc rethkiavfy vaegqedkhs iltntggsqa
     2341 yedfvaglgw evnltnhcgf mgglqknkst glttpyfats tvevifhvst rmpsdsddsl
     2401 tkklrhlgnd evhivwseht rdyrrgiipt efgdvliviy pmknhmfsiq imkkpevpff
     2461 gplfdgaivn gkvlpimvra tainasralk sliplyqnfy eerarylqti vqhhlepttf
     2521 edfaaqvfsp apyhhlpsda gsypeilpse tptatqvdga dlaspmsprt sksrmsmklr
     2581 rssgsanks
//
LOCUS       XP_006720163            2543 aa            linear   PRI 05-AUG-2025
DEFINITION  ral GTPase-activating protein subunit alpha-1 isoform X3 [Homo
            sapiens].
ACCESSION   XP_006720163
VERSION     XP_006720163.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720100.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2543
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2543
                     /product="ral GTPase-activating protein subunit alpha-1
                     isoform X3"
                     /calculated_mol_wt=285281
     Region          550..678
                     /region_name="RALGAPB_N"
                     /note="RALGAPB N-terminal domain; pfam20412"
                     /db_xref="CDD:466561"
     Region          2285..2458
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     CDS             1..2543
                     /gene="RALGAPA1"
                     /gene_synonym="GARNL1; GRIPE; NEDHRIT; p240; RalGAPalpha1;
                     TULIP1"
                     /coded_by="XM_006720100.5:461..8092"
                     /db_xref="GeneID:253959"
                     /db_xref="HGNC:HGNC:17770"
                     /db_xref="MIM:608884"
ORIGIN      
        1 mfskkphgdv kkstqkvldt kkdaltrlkh lrivienaes idlkqffdqh fshiyyvffe
       61 nfvtieaslk qkghksqree ldailfifek ilqllperih qrwqfhsigl ilkkllhtgn
      121 slkirregvr lfllwlqalq nncskeqlwm fsclipgfsa pqsehgprtl dnlinpplnl
      181 qetqvtieei tplvppqsgd kgqedltsyf leallkyivi qvkslewknk enqergfsfl
      241 fshfkkyylp yifpnicken slyhpildip qmrpkphyvv ikkdaetnea iyctkepfik
      301 arvivirwlv sfwlepkpht gphipgmege vlpkniqraa aslvsreesk ndnadktdrt
      361 tepeqshsnt stlterepss sslcsideeh ltdieivrrv fsskrsnvnf vteifrqafl
      421 lpiceaaamr kvvkvyqewi qqeekplfmq epeeivitss dlpcienvtd hdismeegek
      481 reeengtnta dhvrnsswak ngsyqgalhn aseeateqni ragtqavlqv fiinssnifl
      541 lepaneiknl ldehtdmckr ilniyrymvv qvsmdkktwe qmllvllrvt esvlkmpsqa
      601 flqfqgkknm tlagrlagpl fqtlivawik anlnvyisre lwddllsvls sltyweelat
      661 ewsltmetlt kvlarnlysl dlsdlpldkl seqkqkkhkg kgvghefqkv svdksfsrgw
      721 srdqpgqapm rqrsatttgs pgtekarsiv rqktvdidda qilprstrvr hfsqseetgn
      781 evfgalneeq plprssstsd ilepftvera kgavpvidss srhapslqss teassitrst
      841 eshitdthsr esslevgdsi ydhlchligp veladsafeq iqyidlegdd dllstlkeyf
      901 kenqenhskn etgkdpasqe vtiavnrger lsldklectd qetesenits fvgtpenlqf
      961 qkepnsavfm sniapnqsds ffrtqtseks kqlntdkqps epsldspcdk ekrkhlyrqa
     1021 ateldacvdv tlveklksvq inekitvphv mrakkatlka pvnrrmphvt stsklsptkr
     1081 slsetvthra kimkiatkkr nsvhvtfrps tesvqfynpl enkeapwkmr lrklggfssg
     1141 ssnsstsnth tstnsatelv kpgvyrpldt lgtasvsskt vkesteiptt ilqkegiass
     1201 qlgsrstlrs ssheaglqqg slggvyktvv halskpkanv spqrqnrmpp eaplrdlysh
     1261 vmgyfgrkaa vnkedmsqkl pplnsdiggs sanvpdlmde fiaerlrsgn astmtrrgss
     1321 pgsleipkdl pdilnkqnqm rpiddpgvps ewtspasags sdlissdshs dsfsafqydg
     1381 rkfdnfgfgt dtgvtssadv dsgsghhqsa eeqevasltt lhidsetssl nqqafsaeva
     1441 titgsesasp vhsplgsrsq tpspstlnid hmeqkdlqld eklhhsvlqt pddleisefp
     1501 seccsvmagg tltgwhadva tvmwrrmlgi lgdvnsimdp eihaqvfdyl celwqnlaki
     1561 rdnlgistdn ltspsppvli pplriltpwl fkatmltdky kqgklhaykl icntmkrrqd
     1621 vspnrdflth fynimhcgll hidqdivnti ikhcspqffs lglpgatmli mdfivaagrv
     1681 assaflnapr veaqvllgsl vcfpnlycel pslhpnipdv avsqftdvke liiktvlssa
     1741 rdepsgparc valcslgiwi ceelvheshh pqikealnvi cvslkftnkt vahvacnmlh
     1801 mlvhyvprlq iyqpdsplki iqiliatith llpsteassy emdkrlvvsl llclldwima
     1861 lplktllqpf hatgaesdkt eksvlnciyk vlhgcvygaq cfsnpryfpm slsdlasvdy
     1921 dpfmhleslk epeplhspds erssklqpvt evktqmqhgl isiaartvit hlvnhlghyp
     1981 msggpamlts qvcenhdnhy sestelspel fespniqffv lnnttlvsci qirseenmpg
     2041 gglsaglasa nsnvriivrd lsgkyswdsa ilygpppvsg lseptsfmls lshqekpeep
     2101 ptsnecledi tvkdglslqf krfretvptw dtirdeedvl dellqylgvt speclqrtgi
     2161 slnipapqpv cisekqendv inailkqhte ekefvekhfn dlnmkaveqd epipqkpqsa
     2221 fyycrlllsi lgmnswdkrr sfhllkknek llrelrnlds rqcrethkia vfyvaegqed
     2281 khsiltntgg sqayedfvag lgwevnltnh cgfmgglqkn kstglttpyf atstvevifh
     2341 vstrmpsdsd dsltkklrhl gndevhivws ehtrdyrrgi iptefgdvli viypmknhmf
     2401 siqimkkpev pffgplfdga ivngkvlpim vratainasr alksliplyq nfyeeraryl
     2461 qtivqhhlep ttfedfaaqv fspapyhhlp sdavgsypei lpsetptatq vdgadlaspm
     2521 sprtsksrms mklrrssgsa nks
//
LOCUS       XP_047287138            2542 aa            linear   PRI 05-AUG-2025
DEFINITION  ral GTPase-activating protein subunit alpha-1 isoform X4 [Homo
            sapiens].
ACCESSION   XP_047287138
VERSION     XP_047287138.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431182.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2542
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2542
                     /product="ral GTPase-activating protein subunit alpha-1
                     isoform X4"
                     /calculated_mol_wt=285182
     Region          550..678
                     /region_name="RALGAPB_N"
                     /note="RALGAPB N-terminal domain; pfam20412"
                     /db_xref="CDD:466561"
     Region          2285..2458
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     CDS             1..2542
                     /gene="RALGAPA1"
                     /gene_synonym="GARNL1; GRIPE; NEDHRIT; p240; RalGAPalpha1;
                     TULIP1"
                     /coded_by="XM_047431182.1:461..8089"
                     /db_xref="GeneID:253959"
                     /db_xref="HGNC:HGNC:17770"
                     /db_xref="MIM:608884"
ORIGIN      
        1 mfskkphgdv kkstqkvldt kkdaltrlkh lrivienaes idlkqffdqh fshiyyvffe
       61 nfvtieaslk qkghksqree ldailfifek ilqllperih qrwqfhsigl ilkkllhtgn
      121 slkirregvr lfllwlqalq nncskeqlwm fsclipgfsa pqsehgprtl dnlinpplnl
      181 qetqvtieei tplvppqsgd kgqedltsyf leallkyivi qvkslewknk enqergfsfl
      241 fshfkkyylp yifpnicken slyhpildip qmrpkphyvv ikkdaetnea iyctkepfik
      301 arvivirwlv sfwlepkpht gphipgmege vlpkniqraa aslvsreesk ndnadktdrt
      361 tepeqshsnt stlterepss sslcsideeh ltdieivrrv fsskrsnvnf vteifrqafl
      421 lpiceaaamr kvvkvyqewi qqeekplfmq epeeivitss dlpcienvtd hdismeegek
      481 reeengtnta dhvrnsswak ngsyqgalhn aseeateqni ragtqavlqv fiinssnifl
      541 lepaneiknl ldehtdmckr ilniyrymvv qvsmdkktwe qmllvllrvt esvlkmpsqa
      601 flqfqgkknm tlagrlagpl fqtlivawik anlnvyisre lwddllsvls sltyweelat
      661 ewsltmetlt kvlarnlysl dlsdlpldkl seqkqkkhkg kgvghefqkv svdksfsrgw
      721 srdqpgqapm rqrsatttgs pgtekarsiv rqktvdidda qilprstrvr hfsqseetgn
      781 evfgalneeq plprssstsd ilepftvera kgavpvidss srhapslqss teassitrst
      841 eshitdthsr esslevgdsi ydhlchligp veladsafeq iqyidlegdd dllstlkeyf
      901 kenqenhskn etgkdpasqe vtiavnrger lsldklectd qetesenits fvgtpenlqf
      961 qkepnsavfm sniapnqsds ffrtqtseks kqlntdkqps epsldspcdk ekrkhlyrqa
     1021 ateldacvdv tlveklksvq inekitvphv mrakkatlka pvnrrmphvt stsklsptkr
     1081 slsetvthra kimkiatkkr nsvhvtfrps tesvqfynpl enkeapwkmr lrklggfssg
     1141 ssnsstsnth tstnsatelv kpgvyrpldt lgtasvsskt vkesteiptt ilqkegiass
     1201 qlgsrstlrs ssheaglqqg slggvyktvv halskpkanv spqrqnrmpp eaplrdlysh
     1261 vmgyfgrkaa vnkedmsqkl pplnsdiggs sanvpdlmde fiaerlrsgn astmtrrgss
     1321 pgsleipkdl pdilnkqnqm rpiddpgvps ewtspasags sdlissdshs dsfsafqydg
     1381 rkfdnfgfgt dtgvtssadv dsgsghhqsa eeqevasltt lhidsetssl nqqafsaeva
     1441 titgsesasp vhsplgsrsq tpspstlnid hmeqkdlqld eklhhsvlqt pddleisefp
     1501 seccsvmagg tltgwhadva tvmwrrmlgi lgdvnsimdp eihaqvfdyl celwqnlaki
     1561 rdnlgistdn ltspsppvli pplriltpwl fkatmltdky kqgklhaykl icntmkrrqd
     1621 vspnrdflth fynimhcgll hidqdivnti ikhcspqffs lglpgatmli mdfivaagrv
     1681 assaflnapr veaqvllgsl vcfpnlycel pslhpnipdv avsqftdvke liiktvlssa
     1741 rdepsgparc valcslgiwi ceelvheshh pqikealnvi cvslkftnkt vahvacnmlh
     1801 mlvhyvprlq iyqpdsplki iqiliatith llpsteassy emdkrlvvsl llclldwima
     1861 lplktllqpf hatgaesdkt eksvlnciyk vlhgcvygaq cfsnpryfpm slsdlasvdy
     1921 dpfmhleslk epeplhspds erssklqpvt evktqmqhgl isiaartvit hlvnhlghyp
     1981 msggpamlts qvcenhdnhy sestelspel fespniqffv lnnttlvsci qirseenmpg
     2041 gglsaglasa nsnvriivrd lsgkyswdsa ilygpppvsg lseptsfmls lshqekpeep
     2101 ptsnecledi tvkdglslqf krfretvptw dtirdeedvl dellqylgvt speclqrtgi
     2161 slnipapqpv cisekqendv inailkqhte ekefvekhfn dlnmkaveqd epipqkpqsa
     2221 fyycrlllsi lgmnswdkrr sfhllkknek llrelrnlds rqcrethkia vfyvaegqed
     2281 khsiltntgg sqayedfvag lgwevnltnh cgfmgglqkn kstglttpyf atstvevifh
     2341 vstrmpsdsd dsltkklrhl gndevhivws ehtrdyrrgi iptefgdvli viypmknhmf
     2401 siqimkkpev pffgplfdga ivngkvlpim vratainasr alksliplyq nfyeeraryl
     2461 qtivqhhlep ttfedfaaqv fspapyhhlp sdagsypeil psetptatqv dgadlaspms
     2521 prtsksrmsm klrrssgsan ks
//
LOCUS       XP_011534917            2542 aa            linear   PRI 05-AUG-2025
DEFINITION  ral GTPase-activating protein subunit alpha-1 isoform X5 [Homo
            sapiens].
ACCESSION   XP_011534917
VERSION     XP_011534917.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536615.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2542
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2542
                     /product="ral GTPase-activating protein subunit alpha-1
                     isoform X5"
                     /calculated_mol_wt=285304
     Region          550..678
                     /region_name="RALGAPB_N"
                     /note="RALGAPB N-terminal domain; pfam20412"
                     /db_xref="CDD:466561"
     Region          2332..2505
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     CDS             1..2542
                     /gene="RALGAPA1"
                     /gene_synonym="GARNL1; GRIPE; NEDHRIT; p240; RalGAPalpha1;
                     TULIP1"
                     /coded_by="XM_011536615.4:461..8089"
                     /db_xref="GeneID:253959"
                     /db_xref="HGNC:HGNC:17770"
                     /db_xref="MIM:608884"
ORIGIN      
        1 mfskkphgdv kkstqkvldt kkdaltrlkh lrivienaes idlkqffdqh fshiyyvffe
       61 nfvtieaslk qkghksqree ldailfifek ilqllperih qrwqfhsigl ilkkllhtgn
      121 slkirregvr lfllwlqalq nncskeqlwm fsclipgfsa pqsehgprtl dnlinpplnl
      181 qetqvtieei tplvppqsgd kgqedltsyf leallkyivi qvkslewknk enqergfsfl
      241 fshfkkyylp yifpnicken slyhpildip qmrpkphyvv ikkdaetnea iyctkepfik
      301 arvivirwlv sfwlepkpht gphipgmege vlpkniqraa aslvsreesk ndnadktdrt
      361 tepeqshsnt stlterepss sslcsideeh ltdieivrrv fsskrsnvnf vteifrqafl
      421 lpiceaaamr kvvkvyqewi qqeekplfmq epeeivitss dlpcienvtd hdismeegek
      481 reeengtnta dhvrnsswak ngsyqgalhn aseeateqni ragtqavlqv fiinssnifl
      541 lepaneiknl ldehtdmckr ilniyrymvv qvsmdkktwe qmllvllrvt esvlkmpsqa
      601 flqfqgkknm tlagrlagpl fqtlivawik anlnvyisre lwddllsvls sltyweelat
      661 ewsltmetlt kvlarnlysl dlsdlpldkl seqkqkkhkg kgvghefqkv svdksfsrgw
      721 srdqpgqapm rqrsatttgs pgtekarsiv rqktvamrsr sigecalpsa yirsaksapv
      781 lihtskpflp divltplsde lsdiddaqil prstrvrhfs qseetgnevf galneeqplp
      841 rssstsdile pftverakga vpvidsssrh apslqsstea ssitrstesh itdthsress
      901 levgdsiydh lchligpvel adsafeqiqy idlegdddll stlkeyfken qenhsknetg
      961 kdpasqevti avnrgerlsl dklectdqet esenitsfvg tpenlqfqke pnsavfmsni
     1021 apnqsdsffr tqtsekskql ntdkqpseps ldspcdkekr khlyrqaate ldacvdvtlv
     1081 eklksvqine kitvphvmra kkatlkapvn rrmphvtsts klsptkrsls etvthrakim
     1141 kiatkkrnsv hvtfrpstes vqfynplenk eapwkmrlrk lggfssgssn sstsnthtst
     1201 nsatelvkpg vyrpldtlgt asvssktvke steipttilq kegiassqlg srstlrsssh
     1261 eaglqqgslg gvyktvvhal skpkanvspq rqnrmppeap lrdlyshvmg yfgrkaavnk
     1321 edmsqklppl nsdiggssan vpdlmdefia erlrsgnast mtrrgsspgs leipkdlpdi
     1381 lnkqnqmrpi ddpgvpsewt spasagssdl issdshsdsf safqydgrkf dnfgfgtdtg
     1441 vtssadvdsg sghhqsaeeq evaslttlhi dsetsslnqq afsaevatit gsesaspvhs
     1501 plgsrsqtps pstlnidhme qkdlqldekl hhsvlqtpdd leisefpsec csvmaggtlt
     1561 gwhadvatvm wrrmlgilgd vnsimdpeih aqvfdylcel wqnlakirdn lgistdnlts
     1621 psppvlippl riltpwlfka tmltdkykqg klhayklicn tmkrrqdvsp nrdflthfyn
     1681 imhcgllhid qdivntiikh cspqffslgl pgatmlimdf ivaagrvass aflnaprvea
     1741 qvllgslvcf pnlycelpsl hpnipdvavs qftdvkelii ktvlssarde psgparcval
     1801 cslgiwicee lvheshhpqi kealnvicvs lkftnktvah vacnmlhmlv hyvprlqiyq
     1861 pdsplkiiqi liatithllp steassyemd krlvvslllc lldwimalpl ktllqpfhat
     1921 gaesdkteks vlnciykvlh gcvygaqcfs npryfpmsls dlasvdydpf mhleslkepe
     1981 plhspdsers sklqpvtevk tqmqhglisi aartvithlv nhlghypmsg gpamltsqvc
     2041 enhdnhyses telspelfes pniqffvlnn ttlvsciqir seenmpgggl saglasansn
     2101 vriivrdlsg kyswdsaily gpppvsglse ptsfmlslsh qekpeeppts necleditvk
     2161 dglslqfkrf retvptwdti rdeedvldel lqylgvtspe clqrtgisln ipapqpvcis
     2221 ekqendvina ilkqhteeke fvekhfndln mkaveqdepi pqkpqsafyy crlllsilgm
     2281 nswdkrrsfh llkknekllr elrnldsrqc rethkiavfy vaegqedkhs iltntggsqa
     2341 yedfvaglgw evnltnhcgf mgglqknkst glttpyfats tvevifhvst rmpsdsddsl
     2401 tkklrhlgnd evhivwseht rdyrrgiipt efgdvliviy pmknhmfsiq imkkpevpff
     2461 gplfdgaivn gkvlpimvra tainasralk sliplyqnfy eerarylqti vqhhlepttf
     2521 edfaaqvfsp apyhhlpsda dh
//
LOCUS       XP_006720164            2542 aa            linear   PRI 05-AUG-2025
DEFINITION  ral GTPase-activating protein subunit alpha-1 isoform X5 [Homo
            sapiens].
ACCESSION   XP_006720164
VERSION     XP_006720164.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720101.4
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 16% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2542
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2542
                     /product="ral GTPase-activating protein subunit alpha-1
                     isoform X5"
                     /calculated_mol_wt=285304
     Region          550..678
                     /region_name="RALGAPB_N"
                     /note="RALGAPB N-terminal domain; pfam20412"
                     /db_xref="CDD:466561"
     Region          2332..2505
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     CDS             1..2542
                     /gene="RALGAPA1"
                     /gene_synonym="GARNL1; GRIPE; NEDHRIT; p240; RalGAPalpha1;
                     TULIP1"
                     /coded_by="XM_006720101.4:461..8089"
                     /db_xref="GeneID:253959"
                     /db_xref="HGNC:HGNC:17770"
                     /db_xref="MIM:608884"
ORIGIN      
        1 mfskkphgdv kkstqkvldt kkdaltrlkh lrivienaes idlkqffdqh fshiyyvffe
       61 nfvtieaslk qkghksqree ldailfifek ilqllperih qrwqfhsigl ilkkllhtgn
      121 slkirregvr lfllwlqalq nncskeqlwm fsclipgfsa pqsehgprtl dnlinpplnl
      181 qetqvtieei tplvppqsgd kgqedltsyf leallkyivi qvkslewknk enqergfsfl
      241 fshfkkyylp yifpnicken slyhpildip qmrpkphyvv ikkdaetnea iyctkepfik
      301 arvivirwlv sfwlepkpht gphipgmege vlpkniqraa aslvsreesk ndnadktdrt
      361 tepeqshsnt stlterepss sslcsideeh ltdieivrrv fsskrsnvnf vteifrqafl
      421 lpiceaaamr kvvkvyqewi qqeekplfmq epeeivitss dlpcienvtd hdismeegek
      481 reeengtnta dhvrnsswak ngsyqgalhn aseeateqni ragtqavlqv fiinssnifl
      541 lepaneiknl ldehtdmckr ilniyrymvv qvsmdkktwe qmllvllrvt esvlkmpsqa
      601 flqfqgkknm tlagrlagpl fqtlivawik anlnvyisre lwddllsvls sltyweelat
      661 ewsltmetlt kvlarnlysl dlsdlpldkl seqkqkkhkg kgvghefqkv svdksfsrgw
      721 srdqpgqapm rqrsatttgs pgtekarsiv rqktvamrsr sigecalpsa yirsaksapv
      781 lihtskpflp divltplsde lsdiddaqil prstrvrhfs qseetgnevf galneeqplp
      841 rssstsdile pftverakga vpvidsssrh apslqsstea ssitrstesh itdthsress
      901 levgdsiydh lchligpvel adsafeqiqy idlegdddll stlkeyfken qenhsknetg
      961 kdpasqevti avnrgerlsl dklectdqet esenitsfvg tpenlqfqke pnsavfmsni
     1021 apnqsdsffr tqtsekskql ntdkqpseps ldspcdkekr khlyrqaate ldacvdvtlv
     1081 eklksvqine kitvphvmra kkatlkapvn rrmphvtsts klsptkrsls etvthrakim
     1141 kiatkkrnsv hvtfrpstes vqfynplenk eapwkmrlrk lggfssgssn sstsnthtst
     1201 nsatelvkpg vyrpldtlgt asvssktvke steipttilq kegiassqlg srstlrsssh
     1261 eaglqqgslg gvyktvvhal skpkanvspq rqnrmppeap lrdlyshvmg yfgrkaavnk
     1321 edmsqklppl nsdiggssan vpdlmdefia erlrsgnast mtrrgsspgs leipkdlpdi
     1381 lnkqnqmrpi ddpgvpsewt spasagssdl issdshsdsf safqydgrkf dnfgfgtdtg
     1441 vtssadvdsg sghhqsaeeq evaslttlhi dsetsslnqq afsaevatit gsesaspvhs
     1501 plgsrsqtps pstlnidhme qkdlqldekl hhsvlqtpdd leisefpsec csvmaggtlt
     1561 gwhadvatvm wrrmlgilgd vnsimdpeih aqvfdylcel wqnlakirdn lgistdnlts
     1621 psppvlippl riltpwlfka tmltdkykqg klhayklicn tmkrrqdvsp nrdflthfyn
     1681 imhcgllhid qdivntiikh cspqffslgl pgatmlimdf ivaagrvass aflnaprvea
     1741 qvllgslvcf pnlycelpsl hpnipdvavs qftdvkelii ktvlssarde psgparcval
     1801 cslgiwicee lvheshhpqi kealnvicvs lkftnktvah vacnmlhmlv hyvprlqiyq
     1861 pdsplkiiqi liatithllp steassyemd krlvvslllc lldwimalpl ktllqpfhat
     1921 gaesdkteks vlnciykvlh gcvygaqcfs npryfpmsls dlasvdydpf mhleslkepe
     1981 plhspdsers sklqpvtevk tqmqhglisi aartvithlv nhlghypmsg gpamltsqvc
     2041 enhdnhyses telspelfes pniqffvlnn ttlvsciqir seenmpgggl saglasansn
     2101 vriivrdlsg kyswdsaily gpppvsglse ptsfmlslsh qekpeeppts necleditvk
     2161 dglslqfkrf retvptwdti rdeedvldel lqylgvtspe clqrtgisln ipapqpvcis
     2221 ekqendvina ilkqhteeke fvekhfndln mkaveqdepi pqkpqsafyy crlllsilgm
     2281 nswdkrrsfh llkknekllr elrnldsrqc rethkiavfy vaegqedkhs iltntggsqa
     2341 yedfvaglgw evnltnhcgf mgglqknkst glttpyfats tvevifhvst rmpsdsddsl
     2401 tkklrhlgnd evhivwseht rdyrrgiipt efgdvliviy pmknhmfsiq imkkpevpff
     2461 gplfdgaivn gkvlpimvra tainasralk sliplyqnfy eerarylqti vqhhlepttf
     2521 edfaaqvfsp apyhhlpsda dh
//
LOCUS       XP_016876632            2449 aa            linear   PRI 05-AUG-2025
DEFINITION  ral GTPase-activating protein subunit alpha-1 isoform X6 [Homo
            sapiens].
ACCESSION   XP_016876632
VERSION     XP_016876632.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021143.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2449
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2449
                     /product="ral GTPase-activating protein subunit alpha-1
                     isoform X6"
                     /calculated_mol_wt=274197
     Region          550..678
                     /region_name="RALGAPB_N"
                     /note="RALGAPB N-terminal domain; pfam20412"
                     /db_xref="CDD:466561"
     Region          2332..>2413
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     CDS             1..2449
                     /gene="RALGAPA1"
                     /gene_synonym="GARNL1; GRIPE; NEDHRIT; p240; RalGAPalpha1;
                     TULIP1"
                     /coded_by="XM_017021143.3:461..7810"
                     /db_xref="GeneID:253959"
                     /db_xref="HGNC:HGNC:17770"
                     /db_xref="MIM:608884"
ORIGIN      
        1 mfskkphgdv kkstqkvldt kkdaltrlkh lrivienaes idlkqffdqh fshiyyvffe
       61 nfvtieaslk qkghksqree ldailfifek ilqllperih qrwqfhsigl ilkkllhtgn
      121 slkirregvr lfllwlqalq nncskeqlwm fsclipgfsa pqsehgprtl dnlinpplnl
      181 qetqvtieei tplvppqsgd kgqedltsyf leallkyivi qvkslewknk enqergfsfl
      241 fshfkkyylp yifpnicken slyhpildip qmrpkphyvv ikkdaetnea iyctkepfik
      301 arvivirwlv sfwlepkpht gphipgmege vlpkniqraa aslvsreesk ndnadktdrt
      361 tepeqshsnt stlterepss sslcsideeh ltdieivrrv fsskrsnvnf vteifrqafl
      421 lpiceaaamr kvvkvyqewi qqeekplfmq epeeivitss dlpcienvtd hdismeegek
      481 reeengtnta dhvrnsswak ngsyqgalhn aseeateqni ragtqavlqv fiinssnifl
      541 lepaneiknl ldehtdmckr ilniyrymvv qvsmdkktwe qmllvllrvt esvlkmpsqa
      601 flqfqgkknm tlagrlagpl fqtlivawik anlnvyisre lwddllsvls sltyweelat
      661 ewsltmetlt kvlarnlysl dlsdlpldkl seqkqkkhkg kgvghefqkv svdksfsrgw
      721 srdqpgqapm rqrsatttgs pgtekarsiv rqktvamrsr sigecalpsa yirsaksapv
      781 lihtskpflp divltplsde lsdiddaqil prstrvrhfs qseetgnevf galneeqplp
      841 rssstsdile pftverakga vpvidsssrh apslqsstea ssitrstesh itdthsress
      901 levgdsiydh lchligpvel adsafeqiqy idlegdddll stlkeyfken qenhsknetg
      961 kdpasqevti avnrgerlsl dklectdqet esenitsfvg tpenlqfqke pnsavfmsni
     1021 apnqsdsffr tqtsekskql ntdkqpseps ldspcdkekr khlyrqaate ldacvdvtlv
     1081 eklksvqine kitvphvmra kkatlkapvn rrmphvtsts klsptkrsls etvthrakim
     1141 kiatkkrnsv hvtfrpstes vqfynplenk eapwkmrlrk lggfssgssn sstsnthtst
     1201 nsatelvkpg vyrpldtlgt asvssktvke steipttilq kegiassqlg srstlrsssh
     1261 eaglqqgslg gvyktvvhal skpkanvspq rqnrmppeap lrdlyshvmg yfgrkaavnk
     1321 edmsqklppl nsdiggssan vpdlmdefia erlrsgnast mtrrgsspgs leipkdlpdi
     1381 lnkqnqmrpi ddpgvpsewt spasagssdl issdshsdsf safqydgrkf dnfgfgtdtg
     1441 vtssadvdsg sghhqsaeeq evaslttlhi dsetsslnqq afsaevatit gsesaspvhs
     1501 plgsrsqtps pstlnidhme qkdlqldekl hhsvlqtpdd leisefpsec csvmaggtlt
     1561 gwhadvatvm wrrmlgilgd vnsimdpeih aqvfdylcel wqnlakirdn lgistdnlts
     1621 psppvlippl riltpwlfka tmltdkykqg klhayklicn tmkrrqdvsp nrdflthfyn
     1681 imhcgllhid qdivntiikh cspqffslgl pgatmlimdf ivaagrvass aflnaprvea
     1741 qvllgslvcf pnlycelpsl hpnipdvavs qftdvkelii ktvlssarde psgparcval
     1801 cslgiwicee lvheshhpqi kealnvicvs lkftnktvah vacnmlhmlv hyvprlqiyq
     1861 pdsplkiiqi liatithllp steassyemd krlvvslllc lldwimalpl ktllqpfhat
     1921 gaesdkteks vlnciykvlh gcvygaqcfs npryfpmsls dlasvdydpf mhleslkepe
     1981 plhspdsers sklqpvtevk tqmqhglisi aartvithlv nhlghypmsg gpamltsqvc
     2041 enhdnhyses telspelfes pniqffvlnn ttlvsciqir seenmpgggl saglasansn
     2101 vriivrdlsg kyswdsaily gpppvsglse ptsfmlslsh qekpeeppts necleditvk
     2161 dglslqfkrf retvptwdti rdeedvldel lqylgvtspe clqrtgisln ipapqpvcis
     2221 ekqendvina ilkqhteeke fvekhfndln mkaveqdepi pqkpqsafyy crlllsilgm
     2281 nswdkrrsfh llkknekllr elrnldsrqc rethkiavfy vaegqedkhs iltntggsqa
     2341 yedfvaglgw evnltnhcgf mgglqknkst glttpyfats tvevifhvst rmpsdsddsl
     2401 tkklrhwgns viiasniasv pfslsssfgv pitciyifhg sptvfaysv
//
LOCUS       XP_005267549            2130 aa            linear   PRI 05-AUG-2025
DEFINITION  ral GTPase-activating protein subunit alpha-1 isoform X7 [Homo
            sapiens].
ACCESSION   XP_005267549
VERSION     XP_005267549.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267492.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2130
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2130
                     /product="ral GTPase-activating protein subunit alpha-1
                     isoform X7"
                     /calculated_mol_wt=239623
     Region          550..678
                     /region_name="RALGAPB_N"
                     /note="RALGAPB N-terminal domain; pfam20412"
                     /db_xref="CDD:466561"
     Region          1873..2046
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     CDS             1..2130
                     /gene="RALGAPA1"
                     /gene_synonym="GARNL1; GRIPE; NEDHRIT; p240; RalGAPalpha1;
                     TULIP1"
                     /coded_by="XM_005267492.5:461..6853"
                     /db_xref="GeneID:253959"
                     /db_xref="HGNC:HGNC:17770"
                     /db_xref="MIM:608884"
ORIGIN      
        1 mfskkphgdv kkstqkvldt kkdaltrlkh lrivienaes idlkqffdqh fshiyyvffe
       61 nfvtieaslk qkghksqree ldailfifek ilqllperih qrwqfhsigl ilkkllhtgn
      121 slkirregvr lfllwlqalq nncskeqlwm fsclipgfsa pqsehgprtl dnlinpplnl
      181 qetqvtieei tplvppqsgd kgqedltsyf leallkyivi qvkslewknk enqergfsfl
      241 fshfkkyylp yifpnicken slyhpildip qmrpkphyvv ikkdaetnea iyctkepfik
      301 arvivirwlv sfwlepkpht gphipgmege vlpkniqraa aslvsreesk ndnadktdrt
      361 tepeqshsnt stlterepss sslcsideeh ltdieivrrv fsskrsnvnf vteifrqafl
      421 lpiceaaamr kvvkvyqewi qqeekplfmq epeeivitss dlpcienvtd hdismeegek
      481 reeengtnta dhvrnsswak ngsyqgalhn aseeateqni ragtqavlqv fiinssnifl
      541 lepaneiknl ldehtdmckr ilniyrymvv qvsmdkktwe qmllvllrvt esvlkmpsqa
      601 flqfqgkknm tlagrlagpl fqtlivawik anlnvyisre lwddllsvls sltyweelat
      661 ewsltmetlt kvlarnlysl dlsdlpldkl seqkqkkhkg kgvghefqkv svdksfsrgw
      721 srdqpgqapm rqrsatttgs pgtekarsiv rqktvamrsr sigecalpsa yirsaksapv
      781 lihtskpflp divltplsde lsdiddaqil prstrvrhfs qseetgnevf galneeqplp
      841 rssstsdile pftverakvn kedmsqklpp lnsdiggssa nvpdlmdefi aerlrsgnas
      901 tmtrrgsspg sleipkdlpd ilnkqnqmrp iddpgvpsew tspasagssd lissdshsds
      961 fsafqydgrk fdnfgfgtdt gvtssadvds gsghhqsaee qevaslttlh idsetsslnq
     1021 qafsaevati tgsesaspvh splgsrsqtp spstlnidhm eqkdlqldek lhhsvlqtpd
     1081 dleisefpse ccsvmaggtl tgwhadvatv mwrrmlgilg dvnsimdpei haqvfdylce
     1141 lwqnlakird nlgistdnlt spsppvlipp lriltpwlfk atmltdkykq gklhayklic
     1201 ntmkrrqdvs pnrdflthfy nimhcgllhi dqdivntiik hcspqffslg lpgatmlimd
     1261 fivaagrvas saflnaprve aqvllgslvc fpnlycelps lhpnipdvav sqftdvkeli
     1321 iktvlssard epsgparcva lcslgiwice elvheshhpq ikealnvicv slkftnktva
     1381 hvacnmlhml vhyvprlqiy qpdsplkiiq iliatithll psteassyem dkrlvvslll
     1441 clldwimalp lktllqpfha tgaesdktek svlnciykvl hgcvygaqcf snpryfpmsl
     1501 sdlasvdydp fmhleslkep eplhspdser ssklqpvtev ktqmqhglis iaartvithl
     1561 vnhlghypms ggpamltsqv cenhdnhyse stelspelfe spniqffvln nttlvsciqi
     1621 rseenmpggg lsaglasans nvriivrdls gkyswdsail ygpppvsgls eptsfmlsls
     1681 hqekpeeppt snecleditv kdglslqfkr fretvptwdt irdeedvlde llqylgvtsp
     1741 eclqrtgisl nipapqpvci sekqendvin ailkqhteek efvekhfndl nmkaveqdep
     1801 ipqkpqsafy ycrlllsilg mnswdkrrsf hllkknekll relrnldsrq crethkiavf
     1861 yvaegqedkh siltntggsq ayedfvaglg wevnltnhcg fmgglqknks tglttpyfat
     1921 stvevifhvs trmpsdsdds ltkklrhlgn devhivwseh trdyrrgiip tefgdvlivi
     1981 ypmknhmfsi qimkkpevpf fgplfdgaiv ngkvlpimvr atainasral ksliplyqnf
     2041 yeerarylqt ivqhhleptt fedfaaqvfs papyhhlpsd agsypeilps etptatqvdg
     2101 adlaspmspr tsksrmsmkl rrssgsanks
//
LOCUS       XP_016876635            1834 aa            linear   PRI 05-AUG-2025
DEFINITION  ral GTPase-activating protein subunit alpha-1 isoform X8 [Homo
            sapiens].
ACCESSION   XP_016876635
VERSION     XP_016876635.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021146.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1834
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1834
                     /product="ral GTPase-activating protein subunit alpha-1
                     isoform X8"
                     /calculated_mol_wt=203153
     Region          1576..1749
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     CDS             1..1834
                     /gene="RALGAPA1"
                     /gene_synonym="GARNL1; GRIPE; NEDHRIT; p240; RalGAPalpha1;
                     TULIP1"
                     /coded_by="XM_017021146.2:1486..6990"
                     /db_xref="GeneID:253959"
                     /db_xref="HGNC:HGNC:17770"
                     /db_xref="MIM:608884"
ORIGIN      
        1 mrsrsigeca lpsayirsak sapvlihtsk pflpdivltp lsdelsdidd aqilprstrv
       61 rhfsqseetg nevfgalnee qplprsssts dilepftver akgavpvids ssrhapslqs
      121 steassitrs teshitdths resslevgds iydhlchlig pveladsafe qiqyidlegd
      181 ddllstlkey fkenqenhsk netgkdpasq evtiavnrge rlsldklect dqetesenit
      241 sfvgtpenlq fqkepnsavf msniapnqsd sffrtqtsek skqlntdkqp sepsldspcd
      301 kekrkhlyrq aateldacvd vtlveklksv qinekitvph vmrakkatlk apvnrrmphv
      361 tstsklsptk rslsetvthr akimkiatkk rnsvhvtfrp stesvqfynp lenkeapwkm
      421 rlrklggfss gssnsstsnt htstnsatel vkpgvyrpld tlgtasvssk tvkesteipt
      481 tilqkegias sqlgsrstlr sssheaglqq gslggvyktv vhalskpkan vspqrqnrmp
      541 peaplrdlys hvmgyfgrka avnkedmsqk lpplnsdigg ssanvpdlmd efiaerlrsg
      601 nastmtrrgs spgsleipkd lpdilnkqnq mrpiddpgvp sewtspasag ssdlissdsh
      661 sdsfsafqyd grkfdnfgfg tdtgvtssad vdsgsghhqs aeeqevaslt tlhidsetss
      721 lnqqafsaev atitgsesas pvhsplgsrs qtpspstlni dhmeqkdlql deklhhsvlq
      781 tpddleisef pseccsvmag gtltgwhadv atvmwrrmlg ilgdvnsimd peihaqvfdy
      841 lcelwqnlak irdnlgistd nltspsppvl ipplriltpw lfkatmltdk ykqgklhayk
      901 licntmkrrq dvspnrdflt hfynimhcgl lhidqdivnt iikhcspqff slglpgatml
      961 imdfivaagr vassaflnap rveaqvllgs lvcfpnlyce lpslhpnipd vavsqftdvk
     1021 eliiktvlss ardepsgpar cvalcslgiw iceelvhesh hpqikealnv icvslkftnk
     1081 tvahvacnml hmlvhyvprl qiyqpdsplk iiqiliatit hllpsteass yemdkrlvvs
     1141 lllclldwim alplktllqp fhatgaesdk teksvlnciy kvlhgcvyga qcfsnpryfp
     1201 mslsdlasvd ydpfmhlesl kepeplhspd serssklqpv tevktqmqhg lisiaartvi
     1261 thlvnhlghy pmsggpamlt sqvcenhdnh ysestelspe lfespniqff vlnnttlvsc
     1321 iqirseenmp ggglsaglas ansnvriivr dlsgkyswds ailygpppvs glseptsfml
     1381 slshqekpee pptsnecled itvkdglslq fkrfretvpt wdtirdeedv ldellqylgv
     1441 tspeclqrtg islnipapqp vcisekqend vinailkqht eekefvekhf ndlnmkaveq
     1501 depipqkpqs afyycrllls ilgmnswdkr rsfhllkkne kllrelrnld srqcrethki
     1561 avfyvaegqe dkhsiltntg gsqayedfva glgwevnltn hcgfmgglqk nkstglttpy
     1621 fatstvevif hvstrmpsds ddsltkklrh lgndevhivw sehtrdyrrg iiptefgdvl
     1681 iviypmknhm fsiqimkkpe vpffgplfdg aivngkvlpi mvratainas ralksliply
     1741 qnfyeerary lqtivqhhle pttfedfaaq vfspapyhhl psdavgsype ilpsetptat
     1801 qvdgadlasp msprtsksrm smklrrssgs anks
//
LOCUS       XP_006720167            1607 aa            linear   PRI 05-AUG-2025
DEFINITION  ral GTPase-activating protein subunit alpha-1 isoform X9 [Homo
            sapiens].
ACCESSION   XP_006720167
VERSION     XP_006720167.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720104.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1607
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1607
                     /product="ral GTPase-activating protein subunit alpha-1
                     isoform X9"
                     /calculated_mol_wt=180163
     Region          550..678
                     /region_name="RALGAPB_N"
                     /note="RALGAPB N-terminal domain; pfam20412"
                     /db_xref="CDD:466561"
     CDS             1..1607
                     /gene="RALGAPA1"
                     /gene_synonym="GARNL1; GRIPE; NEDHRIT; p240; RalGAPalpha1;
                     TULIP1"
                     /coded_by="XM_006720104.5:461..5284"
                     /db_xref="GeneID:253959"
                     /db_xref="HGNC:HGNC:17770"
                     /db_xref="MIM:608884"
ORIGIN      
        1 mfskkphgdv kkstqkvldt kkdaltrlkh lrivienaes idlkqffdqh fshiyyvffe
       61 nfvtieaslk qkghksqree ldailfifek ilqllperih qrwqfhsigl ilkkllhtgn
      121 slkirregvr lfllwlqalq nncskeqlwm fsclipgfsa pqsehgprtl dnlinpplnl
      181 qetqvtieei tplvppqsgd kgqedltsyf leallkyivi qvkslewknk enqergfsfl
      241 fshfkkyylp yifpnicken slyhpildip qmrpkphyvv ikkdaetnea iyctkepfik
      301 arvivirwlv sfwlepkpht gphipgmege vlpkniqraa aslvsreesk ndnadktdrt
      361 tepeqshsnt stlterepss sslcsideeh ltdieivrrv fsskrsnvnf vteifrqafl
      421 lpiceaaamr kvvkvyqewi qqeekplfmq epeeivitss dlpcienvtd hdismeegek
      481 reeengtnta dhvrnsswak ngsyqgalhn aseeateqni ragtqavlqv fiinssnifl
      541 lepaneiknl ldehtdmckr ilniyrymvv qvsmdkktwe qmllvllrvt esvlkmpsqa
      601 flqfqgkknm tlagrlagpl fqtlivawik anlnvyisre lwddllsvls sltyweelat
      661 ewsltmetlt kvlarnlysl dlsdlpldkl seqkqkkhkg kgvghefqkv svdksfsrgw
      721 srdqpgqapm rqrsatttgs pgtekarsiv rqktvamrsr sigecalpsa yirsaksapv
      781 lihtskpflp divltplsde lsdiddaqil prstrvrhfs qseetgnevf galneeqplp
      841 rssstsdile pftverakga vpvidsssrh apslqsstea ssitrstesh itdthsress
      901 levgdsiydh lchligpvel adsafeqiqy idlegdddll stlkeyfken qenhsknetg
      961 kdpasqevti avnrgerlsl dklectdqet esenitsfvg tpenlqfqke pnsavfmsni
     1021 apnqsdsffr tqtsekskql ntdkqpseps ldspcdkekr khlyrqaate ldacvdvtlv
     1081 eklksvqine kitvphvmra kkatlkapvn rrmphvtsts klsptkrsls etvthrakim
     1141 kiatkkrnsv hvtfrpstes vqfynplenk eapwkmrlrk lggfssgssn sstsnthtst
     1201 nsatelvkpg vyrpldtlgt asvssktvke steipttilq kegiassqlg srstlrsssh
     1261 eaglqqgslg gvyktvvhal skpkanvspq rqnrmppeap lrdlyshvmg yfgrkaavnk
     1321 edmsqklppl nsdiggssan vpdlmdefia erlrsgnast mtrrgsspgs leipkdlpdi
     1381 lnkqnqmrpi ddpgvpsewt spasagssdl issdshsdsf safqydgrkf dnfgfgtdtg
     1441 vtssadvdsg sghhqsaeeq evaslttlhi dsetsslnqq afsaevatit gsesaspvhs
     1501 plgsrsqtps pstlnidhme qkdlqldekl hhsvlqtpdd leisefpsec csvmaggtlt
     1561 gwhadvatvm wrrmlgilgd vnsimdpeih aqvfdylcel wqnlakf
//
LOCUS       XP_024305291            1574 aa            linear   PRI 05-AUG-2025
DEFINITION  ral GTPase-activating protein subunit alpha-1 isoform X10 [Homo
            sapiens].
ACCESSION   XP_024305291
VERSION     XP_024305291.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449523.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1574
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1574
                     /product="ral GTPase-activating protein subunit alpha-1
                     isoform X10"
                     /calculated_mol_wt=174493
     Region          1316..1489
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     CDS             1..1574
                     /gene="RALGAPA1"
                     /gene_synonym="GARNL1; GRIPE; NEDHRIT; p240; RalGAPalpha1;
                     TULIP1"
                     /coded_by="XM_024449523.2:2123..6847"
                     /db_xref="GeneID:253959"
                     /db_xref="HGNC:HGNC:17770"
                     /db_xref="MIM:608884"
ORIGIN      
        1 msniapnqsd sffrtqtsek skqlntdkqp sepsldspcd kekrkhlyrq aateldacvd
       61 vtlveklksv qinekitvph vmrakkatlk apvnrrmphv tstsklsptk rslsetvthr
      121 akimkiatkk rnsvhvtfrp stesvqfynp lenkeapwkm rlrklggfss gssnsstsnt
      181 htstnsatel vkpgvyrpld tlgtasvssk tvkesteipt tilqkegias sqlgsrstlr
      241 sssheaglqq gslggvyktv vhalskpkan vspqrqnrmp peaplrdlys hvmgyfgrka
      301 avnkedmsqk lpplnsdigg ssanvpdlmd efiaerlrsg nastmtrrgs spgsleipkd
      361 lpdilnkqnq mrpiddpgvp sewtspasag ssdlissdsh sdsfsafqyd grkfdnfgfg
      421 tdtgvtssad vdsgsghhqs aeeqevaslt tlhidsetss lnqqafsaev atitgsesas
      481 pvhsplgsrs qtpspstlni dhmeqkdlql deklhhsvlq tpddleisef pseccsvmag
      541 gtltgwhadv atvmwrrmlg ilgdvnsimd peihaqvfdy lcelwqnlak irdnlgistd
      601 nltspsppvl ipplriltpw lfkatmltdk ykqgklhayk licntmkrrq dvspnrdflt
      661 hfynimhcgl lhidqdivnt iikhcspqff slglpgatml imdfivaagr vassaflnap
      721 rveaqvllgs lvcfpnlyce lpslhpnipd vavsqftdvk eliiktvlss ardepsgpar
      781 cvalcslgiw iceelvhesh hpqikealnv icvslkftnk tvahvacnml hmlvhyvprl
      841 qiyqpdsplk iiqiliatit hllpsteass yemdkrlvvs lllclldwim alplktllqp
      901 fhatgaesdk teksvlnciy kvlhgcvyga qcfsnpryfp mslsdlasvd ydpfmhlesl
      961 kepeplhspd serssklqpv tevktqmqhg lisiaartvi thlvnhlghy pmsggpamlt
     1021 sqvcenhdnh ysestelspe lfespniqff vlnnttlvsc iqirseenmp ggglsaglas
     1081 ansnvriivr dlsgkyswds ailygpppvs glseptsfml slshqekpee pptsnecled
     1141 itvkdglslq fkrfretvpt wdtirdeedv ldellqylgv tspeclqrtg islnipapqp
     1201 vcisekqend vinailkqht eekefvekhf ndlnmkaveq depipqkpqs afyycrllls
     1261 ilgmnswdkr rsfhllkkne kllrelrnld srqcrethki avfyvaegqe dkhsiltntg
     1321 gsqayedfva glgwevnltn hcgfmgglqk nkstglttpy fatstvevif hvstrmpsds
     1381 ddsltkklrh lgndevhivw sehtrdyrrg iiptefgdvl iviypmknhm fsiqimkkpe
     1441 vpffgplfdg aivngkvlpi mvratainas ralksliply qnfyeerary lqtivqhhle
     1501 pttfedfaaq vfspapyhhl psdavgsype ilpsetptat qvdgadlasp msprtsksrm
     1561 smklrrssgs anks
//
LOCUS       XP_005267555            1325 aa            linear   PRI 05-AUG-2025
DEFINITION  ral GTPase-activating protein subunit alpha-1 isoform X11 [Homo
            sapiens].
ACCESSION   XP_005267555
VERSION     XP_005267555.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267498.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1325
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1325
                     /product="ral GTPase-activating protein subunit alpha-1
                     isoform X11"
                     /calculated_mol_wt=147300
     Region          1067..1240
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     CDS             1..1325
                     /gene="RALGAPA1"
                     /gene_synonym="GARNL1; GRIPE; NEDHRIT; p240; RalGAPalpha1;
                     TULIP1"
                     /coded_by="XM_005267498.5:1573..5550"
                     /db_xref="GeneID:253959"
                     /db_xref="HGNC:HGNC:17770"
                     /db_xref="MIM:608884"
ORIGIN      
        1 mrsshcleva alltswnhsl lnepkrqnrm ppeaplrdly shvmgyfgrk aavnkedmsq
       61 klpplnsdig gssanvpdlm defiaerlrs gnastmtrrg sspgsleipk dlpdilnkqn
      121 qmrpiddpgv psewtspasa gssdlissds hsdsfsafqy dgrkfdnfgf gtdtgvtssa
      181 dvdsgsghhq saeeqevasl ttlhidsets slnqqafsae vatitgsesa spvhsplgsr
      241 sqtpspstln idhmeqkdlq ldeklhhsvl qtpddleise fpseccsvma ggtltgwhad
      301 vatvmwrrml gilgdvnsim dpeihaqvfd ylcelwqnla kirdnlgist dnltspsppv
      361 lipplriltp wlfkatmltd kykqgklhay klicntmkrr qdvspnrdfl thfynimhcg
      421 llhidqdivn tiikhcspqf fslglpgatm limdfivaag rvassaflna prveaqvllg
      481 slvcfpnlyc elpslhpnip dvavsqftdv keliiktvls sardepsgpa rcvalcslgi
      541 wiceelvhes hhpqikealn vicvslkftn ktvahvacnm lhmlvhyvpr lqiyqpdspl
      601 kiiqiliati thllpsteas syemdkrlvv slllclldwi malplktllq pfhatgaesd
      661 kteksvlnci ykvlhgcvyg aqcfsnpryf pmslsdlasv dydpfmhles lkepeplhsp
      721 dserssklqp vtevktqmqh glisiaartv ithlvnhlgh ypmsggpaml tsqvcenhdn
      781 hysestelsp elfespniqf fvlnnttlvs ciqirseenm pggglsagla sansnvriiv
      841 rdlsgkyswd sailygpppv sglseptsfm lslshqekpe epptsnecle ditvkdglsl
      901 qfkrfretvp twdtirdeed vldellqylg vtspeclqrt gislnipapq pvcisekqen
      961 dvinailkqh teekefvekh fndlnmkave qdepipqkpq safyycrlll silgmnswdk
     1021 rrsfhllkkn ekllrelrnl dsrqcrethk iavfyvaegq edkhsiltnt ggsqayedfv
     1081 aglgwevnlt nhcgfmgglq knkstglttp yfatstvevi fhvstrmpsd sddsltkklr
     1141 hlgndevhiv wsehtrdyrr giiptefgdv liviypmknh mfsiqimkkp evpffgplfd
     1201 gaivngkvlp imvrataina sralkslipl yqnfyeerar ylqtivqhhl epttfedfaa
     1261 qvfspapyhh lpsdavgsyp eilpsetpta tqvdgadlas pmsprtsksr msmklrrssg
     1321 sanks
//
LOCUS       XP_047287139             304 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein CCDC197 isoform X1 [Homo sapiens].
ACCESSION   XP_047287139
VERSION     XP_047287139.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431183.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..304
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..304
                     /product="uncharacterized protein CCDC197 isoform X1"
                     /calculated_mol_wt=34087
     Region          <18..59
                     /region_name="DUF4200"
                     /note="Domain of unknown function (DUF4200); pfam13863"
                     /db_xref="CDD:464003"
     CDS             1..304
                     /gene="CCDC197"
                     /gene_synonym="C14orf48; c14_5713; LINC00521"
                     /coded_by="XM_047431183.1:405..1319"
                     /db_xref="GeneID:256369"
                     /db_xref="HGNC:HGNC:19860"
ORIGIN      
        1 maamdtgqra dpsnpgdkeg dlqglwqely qlqakqkklk revekhklfe dylikvleki
       61 pegcskqqhl legslpprsv vliqnpclsl wlnfprlhgm ggagggaggg hgealrealh
      121 sqpghaeapr gllpddpgcp pepgvsgggp qgshslkirl cqlqkkcyrk qeqwwqlkhs
      181 ityqkdidfd thtsssyndq llgymqmtit nmarqccpsa hgvpksmdlf skldlikefm
      241 ldkmetvrli alltepkvcw swdsfgdqwl rrhpkpfrkc prrrvstprt pfpsphasec
      301 sgly
//
LOCUS       XP_047287140             304 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein CCDC197 isoform X1 [Homo sapiens].
ACCESSION   XP_047287140
VERSION     XP_047287140.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431184.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..304
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..304
                     /product="uncharacterized protein CCDC197 isoform X1"
                     /calculated_mol_wt=34087
     Region          <18..59
                     /region_name="DUF4200"
                     /note="Domain of unknown function (DUF4200); pfam13863"
                     /db_xref="CDD:464003"
     CDS             1..304
                     /gene="CCDC197"
                     /gene_synonym="C14orf48; c14_5713; LINC00521"
                     /coded_by="XM_047431184.1:287..1201"
                     /db_xref="GeneID:256369"
                     /db_xref="HGNC:HGNC:19860"
ORIGIN      
        1 maamdtgqra dpsnpgdkeg dlqglwqely qlqakqkklk revekhklfe dylikvleki
       61 pegcskqqhl legslpprsv vliqnpclsl wlnfprlhgm ggagggaggg hgealrealh
      121 sqpghaeapr gllpddpgcp pepgvsgggp qgshslkirl cqlqkkcyrk qeqwwqlkhs
      181 ityqkdidfd thtsssyndq llgymqmtit nmarqccpsa hgvpksmdlf skldlikefm
      241 ldkmetvrli alltepkvcw swdsfgdqwl rrhpkpfrkc prrrvstprt pfpsphasec
      301 sgly
//
LOCUS       XP_047287141             304 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein CCDC197 isoform X1 [Homo sapiens].
ACCESSION   XP_047287141
VERSION     XP_047287141.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431185.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..304
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..304
                     /product="uncharacterized protein CCDC197 isoform X1"
                     /calculated_mol_wt=34087
     Region          <18..59
                     /region_name="DUF4200"
                     /note="Domain of unknown function (DUF4200); pfam13863"
                     /db_xref="CDD:464003"
     CDS             1..304
                     /gene="CCDC197"
                     /gene_synonym="C14orf48; c14_5713; LINC00521"
                     /coded_by="XM_047431185.1:414..1328"
                     /db_xref="GeneID:256369"
                     /db_xref="HGNC:HGNC:19860"
ORIGIN      
        1 maamdtgqra dpsnpgdkeg dlqglwqely qlqakqkklk revekhklfe dylikvleki
       61 pegcskqqhl legslpprsv vliqnpclsl wlnfprlhgm ggagggaggg hgealrealh
      121 sqpghaeapr gllpddpgcp pepgvsgggp qgshslkirl cqlqkkcyrk qeqwwqlkhs
      181 ityqkdidfd thtsssyndq llgymqmtit nmarqccpsa hgvpksmdlf skldlikefm
      241 ldkmetvrli alltepkvcw swdsfgdqwl rrhpkpfrkc prrrvstprt pfpsphasec
      301 sgly
//
LOCUS       XP_047287142             304 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein CCDC197 isoform X1 [Homo sapiens].
ACCESSION   XP_047287142
VERSION     XP_047287142.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431186.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..304
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..304
                     /product="uncharacterized protein CCDC197 isoform X1"
                     /calculated_mol_wt=34087
     Region          <18..59
                     /region_name="DUF4200"
                     /note="Domain of unknown function (DUF4200); pfam13863"
                     /db_xref="CDD:464003"
     CDS             1..304
                     /gene="CCDC197"
                     /gene_synonym="C14orf48; c14_5713; LINC00521"
                     /coded_by="XM_047431186.1:289..1203"
                     /db_xref="GeneID:256369"
                     /db_xref="HGNC:HGNC:19860"
ORIGIN      
        1 maamdtgqra dpsnpgdkeg dlqglwqely qlqakqkklk revekhklfe dylikvleki
       61 pegcskqqhl legslpprsv vliqnpclsl wlnfprlhgm ggagggaggg hgealrealh
      121 sqpghaeapr gllpddpgcp pepgvsgggp qgshslkirl cqlqkkcyrk qeqwwqlkhs
      181 ityqkdidfd thtsssyndq llgymqmtit nmarqccpsa hgvpksmdlf skldlikefm
      241 ldkmetvrli alltepkvcw swdsfgdqwl rrhpkpfrkc prrrvstprt pfpsphasec
      301 sgly
//
LOCUS       XP_047287143             304 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein CCDC197 isoform X1 [Homo sapiens].
ACCESSION   XP_047287143
VERSION     XP_047287143.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431187.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..304
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..304
                     /product="uncharacterized protein CCDC197 isoform X1"
                     /calculated_mol_wt=34087
     Region          <18..59
                     /region_name="DUF4200"
                     /note="Domain of unknown function (DUF4200); pfam13863"
                     /db_xref="CDD:464003"
     CDS             1..304
                     /gene="CCDC197"
                     /gene_synonym="C14orf48; c14_5713; LINC00521"
                     /coded_by="XM_047431187.1:171..1085"
                     /db_xref="GeneID:256369"
                     /db_xref="HGNC:HGNC:19860"
ORIGIN      
        1 maamdtgqra dpsnpgdkeg dlqglwqely qlqakqkklk revekhklfe dylikvleki
       61 pegcskqqhl legslpprsv vliqnpclsl wlnfprlhgm ggagggaggg hgealrealh
      121 sqpghaeapr gllpddpgcp pepgvsgggp qgshslkirl cqlqkkcyrk qeqwwqlkhs
      181 ityqkdidfd thtsssyndq llgymqmtit nmarqccpsa hgvpksmdlf skldlikefm
      241 ldkmetvrli alltepkvcw swdsfgdqwl rrhpkpfrkc prrrvstprt pfpsphasec
      301 sgly
//
LOCUS       XP_024305293             272 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein CCDC197 isoform X2 [Homo sapiens].
ACCESSION   XP_024305293
VERSION     XP_024305293.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449525.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..272
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..272
                     /product="uncharacterized protein CCDC197 isoform X2"
                     /calculated_mol_wt=31755
     CDS             1..272
                     /gene="CCDC197"
                     /gene_synonym="C14orf48; c14_5713; LINC00521"
                     /coded_by="XM_024449525.2:42..860"
                     /db_xref="GeneID:256369"
                     /db_xref="HGNC:HGNC:19860"
ORIGIN      
        1 maamdtgqra dpsnpgdkeg dlqglwqely qlqakqkklk revekhklfe dylikvleki
       61 pegctgweep eevlveatvk hygklftasq dtqkrleafc qmiqavhrsl esleedhral
      121 mlslkirlcq lqkkcyrkqe qwwqlkhsit yqkdidfdth tsssyndqll gymqmtitnm
      181 arqccpsahg vpksmdlfsk ldlikefmld kmetvrlial ltepkvcwsw dsfgdqwlrr
      241 hpkpfrkcpr rrvstprtpf psphasecsg ly
//
LOCUS       XP_024305292             272 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein CCDC197 isoform X2 [Homo sapiens].
ACCESSION   XP_024305292
VERSION     XP_024305292.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449524.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..272
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..272
                     /product="uncharacterized protein CCDC197 isoform X2"
                     /calculated_mol_wt=31755
     CDS             1..272
                     /gene="CCDC197"
                     /gene_synonym="C14orf48; c14_5713; LINC00521"
                     /coded_by="XM_024449524.2:289..1107"
                     /db_xref="GeneID:256369"
                     /db_xref="HGNC:HGNC:19860"
ORIGIN      
        1 maamdtgqra dpsnpgdkeg dlqglwqely qlqakqkklk revekhklfe dylikvleki
       61 pegctgweep eevlveatvk hygklftasq dtqkrleafc qmiqavhrsl esleedhral
      121 mlslkirlcq lqkkcyrkqe qwwqlkhsit yqkdidfdth tsssyndqll gymqmtitnm
      181 arqccpsahg vpksmdlfsk ldlikefmld kmetvrlial ltepkvcwsw dsfgdqwlrr
      241 hpkpfrkcpr rrvstprtpf psphasecsg ly
//
LOCUS       XP_047287144             272 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein CCDC197 isoform X2 [Homo sapiens].
ACCESSION   XP_047287144
VERSION     XP_047287144.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431188.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..272
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..272
                     /product="uncharacterized protein CCDC197 isoform X2"
                     /calculated_mol_wt=31755
     CDS             1..272
                     /gene="CCDC197"
                     /gene_synonym="C14orf48; c14_5713; LINC00521"
                     /coded_by="XM_047431188.1:158..976"
                     /db_xref="GeneID:256369"
                     /db_xref="HGNC:HGNC:19860"
ORIGIN      
        1 maamdtgqra dpsnpgdkeg dlqglwqely qlqakqkklk revekhklfe dylikvleki
       61 pegctgweep eevlveatvk hygklftasq dtqkrleafc qmiqavhrsl esleedhral
      121 mlslkirlcq lqkkcyrkqe qwwqlkhsit yqkdidfdth tsssyndqll gymqmtitnm
      181 arqccpsahg vpksmdlfsk ldlikefmld kmetvrlial ltepkvcwsw dsfgdqwlrr
      241 hpkpfrkcpr rrvstprtpf psphasecsg ly
//
LOCUS       XP_047287145             272 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein CCDC197 isoform X2 [Homo sapiens].
ACCESSION   XP_047287145
VERSION     XP_047287145.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431189.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..272
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..272
                     /product="uncharacterized protein CCDC197 isoform X2"
                     /calculated_mol_wt=31755
     CDS             1..272
                     /gene="CCDC197"
                     /gene_synonym="C14orf48; c14_5713; LINC00521"
                     /coded_by="XM_047431189.1:287..1105"
                     /db_xref="GeneID:256369"
                     /db_xref="HGNC:HGNC:19860"
ORIGIN      
        1 maamdtgqra dpsnpgdkeg dlqglwqely qlqakqkklk revekhklfe dylikvleki
       61 pegctgweep eevlveatvk hygklftasq dtqkrleafc qmiqavhrsl esleedhral
      121 mlslkirlcq lqkkcyrkqe qwwqlkhsit yqkdidfdth tsssyndqll gymqmtitnm
      181 arqccpsahg vpksmdlfsk ldlikefmld kmetvrlial ltepkvcwsw dsfgdqwlrr
      241 hpkpfrkcpr rrvstprtpf psphasecsg ly
//
LOCUS       XP_047287146             254 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein CCDC197 isoform X3 [Homo sapiens].
ACCESSION   XP_047287146
VERSION     XP_047287146.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431190.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..254
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..254
                     /product="uncharacterized protein CCDC197 isoform X3"
                     /calculated_mol_wt=28104
     Region          <18..59
                     /region_name="DUF4200"
                     /note="Domain of unknown function (DUF4200); pfam13863"
                     /db_xref="CDD:464003"
     CDS             1..254
                     /gene="CCDC197"
                     /gene_synonym="C14orf48; c14_5713; LINC00521"
                     /coded_by="XM_047431190.1:405..1169"
                     /db_xref="GeneID:256369"
                     /db_xref="HGNC:HGNC:19860"
ORIGIN      
        1 maamdtgqra dpsnpgdkeg dlqglwqely qlqakqkklk revekhklfe dylikvleki
       61 pegcskqqhl legslpprsv vliqnpclsl wlnfprlhgm ggagggaggg hgealrealh
      121 sqpghaeapr gllpddpgcp pepgvsgggp qgshslkirl cqlqkkcyrk qeqwwqlkhs
      181 ityqkdidfd thtsssyndq llgymqmtit nmarqccpsa hgvpksmdlf skldlikrqg
      241 ftklarlvfn sdlk
//
LOCUS       XP_047287147             243 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein CCDC197 isoform X4 [Homo sapiens].
ACCESSION   XP_047287147
VERSION     XP_047287147.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431191.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..243
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..243
                     /product="uncharacterized protein CCDC197 isoform X4"
                     /calculated_mol_wt=26910
     CDS             1..243
                     /gene="CCDC197"
                     /gene_synonym="C14orf48; c14_5713; LINC00521"
                     /coded_by="XM_047431191.1:405..1136"
                     /db_xref="GeneID:256369"
                     /db_xref="HGNC:HGNC:19860"
ORIGIN      
        1 maamdtgqra dpsnpgdkeg dlqglwqely qlqaklhgmg gagggagggh gealrealhs
       61 qpghaeaprg llpddpgcpp epgvsgggpq gshslkirlc qlqkkcyrkq eqwwqlkhsi
      121 tyqkdidfdt htsssyndql lgymqmtitn marqccpsah gvpksmdlfs kldlikefml
      181 dkmetvrlia lltepkvcws wdsfgdqwlr rhpkpfrkcp rrrvstprtp fpsphasecs
      241 gly
//
LOCUS       XP_047287148             242 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein CCDC197 isoform X5 [Homo sapiens].
ACCESSION   XP_047287148
VERSION     XP_047287148.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431192.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..242
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..242
                     /product="uncharacterized protein CCDC197 isoform X5"
                     /calculated_mol_wt=26576
     Region          <18..59
                     /region_name="DUF4200"
                     /note="Domain of unknown function (DUF4200); pfam13863"
                     /db_xref="CDD:464003"
     CDS             1..242
                     /gene="CCDC197"
                     /gene_synonym="C14orf48; c14_5713; LINC00521"
                     /coded_by="XM_047431192.1:405..1133"
                     /db_xref="GeneID:256369"
                     /db_xref="HGNC:HGNC:19860"
ORIGIN      
        1 maamdtgqra dpsnpgdkeg dlqglwqely qlqakqkklk revekhklfe dylikvleki
       61 pegcskqqhl legslpprsv vliqnpclsl wlnfprlhgm ggagggaggg hgealrealh
      121 sqpghaeapr gllpddpgcp pepgvsgggp qgshslkirl cqlqkkcyrk qeqwwqlkhs
      181 ityqkdidfd thtsssyndq llgymqmtit nmarqccpsa hgvpksmdlf skldlikgac
      241 es
//
LOCUS       XP_047287149             243 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein CCDC197 isoform X4 [Homo sapiens].
ACCESSION   XP_047287149
VERSION     XP_047287149.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431193.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..243
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..243
                     /product="uncharacterized protein CCDC197 isoform X4"
                     /calculated_mol_wt=26910
     CDS             1..243
                     /gene="CCDC197"
                     /gene_synonym="C14orf48; c14_5713; LINC00521"
                     /coded_by="XM_047431193.1:158..889"
                     /db_xref="GeneID:256369"
                     /db_xref="HGNC:HGNC:19860"
ORIGIN      
        1 maamdtgqra dpsnpgdkeg dlqglwqely qlqaklhgmg gagggagggh gealrealhs
       61 qpghaeaprg llpddpgcpp epgvsgggpq gshslkirlc qlqkkcyrkq eqwwqlkhsi
      121 tyqkdidfdt htsssyndql lgymqmtitn marqccpsah gvpksmdlfs kldlikefml
      181 dkmetvrlia lltepkvcws wdsfgdqwlr rhpkpfrkcp rrrvstprtp fpsphasecs
      241 gly
//
LOCUS       XP_047287150             304 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein CCDC197 isoform X1 [Homo sapiens].
ACCESSION   XP_047287150
VERSION     XP_047287150.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431194.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..304
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..304
                     /product="uncharacterized protein CCDC197 isoform X1"
                     /calculated_mol_wt=34087
     Region          <18..59
                     /region_name="DUF4200"
                     /note="Domain of unknown function (DUF4200); pfam13863"
                     /db_xref="CDD:464003"
     CDS             1..304
                     /gene="CCDC197"
                     /gene_synonym="C14orf48; c14_5713; LINC00521"
                     /coded_by="XM_047431194.1:388..1302"
                     /db_xref="GeneID:256369"
                     /db_xref="HGNC:HGNC:19860"
ORIGIN      
        1 maamdtgqra dpsnpgdkeg dlqglwqely qlqakqkklk revekhklfe dylikvleki
       61 pegcskqqhl legslpprsv vliqnpclsl wlnfprlhgm ggagggaggg hgealrealh
      121 sqpghaeapr gllpddpgcp pepgvsgggp qgshslkirl cqlqkkcyrk qeqwwqlkhs
      181 ityqkdidfd thtsssyndq llgymqmtit nmarqccpsa hgvpksmdlf skldlikefm
      241 ldkmetvrli alltepkvcw swdsfgdqwl rrhpkpfrkc prrrvstprt pfpsphasec
      301 sgly
//
LOCUS       XP_047287152             171 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein CCDC197 isoform X6 [Homo sapiens].
ACCESSION   XP_047287152
VERSION     XP_047287152.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431196.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..171
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..171
                     /product="uncharacterized protein CCDC197 isoform X6"
                     /calculated_mol_wt=20133
     CDS             1..171
                     /gene="CCDC197"
                     /gene_synonym="C14orf48; c14_5713; LINC00521"
                     /coded_by="XM_047431196.1:322..837"
                     /db_xref="GeneID:256369"
                     /db_xref="HGNC:HGNC:19860"
ORIGIN      
        1 miqavhrsle sleedhralm lslkirlcql qkkcyrkqeq wwqlkhsity qkdidfdtht
       61 sssyndqllg ymqmtitnma rqccpsahgv pksmdlfskl dlikefmldk metvrliall
      121 tepkvcwswd sfgdqwlrrh pkpfrkcprr rvstprtpfp sphasecsgl y
//
LOCUS       XP_047287153             168 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein CCDC197 isoform X7 [Homo sapiens].
ACCESSION   XP_047287153
VERSION     XP_047287153.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431197.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..168
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..168
                     /product="uncharacterized protein CCDC197 isoform X7"
                     /calculated_mol_wt=19539
     CDS             1..168
                     /gene="CCDC197"
                     /gene_synonym="C14orf48; c14_5713; LINC00521"
                     /coded_by="XM_047431197.1:181..687"
                     /db_xref="GeneID:256369"
                     /db_xref="HGNC:HGNC:19860"
ORIGIN      
        1 mlplgpgtsg sqrkddqpsl kirlcqlqkk cyrkqeqwwq lkhsityqkd idfdthtsss
       61 yndqllgymq mtitnmarqc cpsahgvpks mdlfskldli kefmldkmet vrlialltep
      121 kvcwswdsfg dqwlrrhpkp frkcprrrvs tprtpfpsph asecsgly
//
LOCUS       XP_047287155             569 aa            linear   PRI 05-AUG-2025
DEFINITION  galactocerebrosidase isoform X2 [Homo sapiens].
ACCESSION   XP_047287155
VERSION     XP_047287155.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431199.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..569
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..569
                     /product="galactocerebrosidase isoform X2"
                     /calculated_mol_wt=64873
     Region          <1..233
                     /region_name="Glyco_hydro_30"
                     /note="Glycosyl hydrolase family 30 TIM-barrel domain;
                     cl23815"
                     /db_xref="CDD:451560"
     Region          241..348
                     /region_name="Glyco_hydro_59M"
                     /note="Glycosyl hydrolase family 59 central domain;
                     pfam17387"
                     /db_xref="CDD:465411"
     CDS             1..569
                     /gene="GALC"
                     /coded_by="XM_047431199.1:125..1834"
                     /db_xref="GeneID:2581"
                     /db_xref="HGNC:HGNC:4115"
                     /db_xref="MIM:606890"
ORIGIN      
        1 mhyaldenyf rgyewwlmke akkrnpnitl iglpwsfpgw lgkgfdwpyv nlqltayyvv
       61 twivgakryh dldidyigiw nersynanyi kilrkmlnyq glqrvkiias dnlwesisas
      121 mlldaelfkv vdvigahypg thsakdaklt gkklwssedf stlnsdmgag cwgrilnqny
      181 ingymtstia wnlvasyyeq lpygrcglmt aqepwsghyv vespvwvsah ttqftqpgwy
      241 ylktvghlek ggsyvaltdg lgnltiiiet mshkhskcir pflpyfnvsq qfatfvlkgs
      301 fseipelqvw ytklgktser flfkqldslw lldsdgsftl slhedelftl ttlttgrkgs
      361 yplppksqpf pstykddfnv dypffseapn fadqtgvfey ftniedpgeh hftlrqvlnq
      421 rpitwaadas ntisiigdyn wtnltikcdv yietpdtggv fiagrvnkgg ilirsargif
      481 fwifangsyr vtgdlagwii yalgrvevta kkwytltlti kghftsgmln dkslwtdipv
      541 nfpkngwaai gthsfefaqf dnflveatr
//
LOCUS       XP_011534921            2608 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase HECTD1 isoform X2 [Homo sapiens].
ACCESSION   XP_011534921
VERSION     XP_011534921.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536619.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2608
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2608
                     /product="E3 ubiquitin-protein ligase HECTD1 isoform X2"
                     /calculated_mol_wt=289008
     Region          <366..>479
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          366..393
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          396..426
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(397,401..402,405..407,409..410,414,417,426,428,
                     432..433,436..438,440..441,445,448,457,459,461,465..466,
                     469..471,473..474,478)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          428..457
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          1107..1240
                     /region_name="Sad1_UNC"
                     /note="Sad1 / UNC-like C-terminal; pfam07738"
                     /db_xref="CDD:400199"
     Region          1277..1335
                     /region_name="MIB_HERC2"
                     /note="Mib_herc2; pfam06701"
                     /db_xref="CDD:461991"
     Region          1891..1956
                     /region_name="BTHB_HectD1"
                     /note="basic tilted helix bundle (BTHB) domain found in
                     HECT domain-containing protein 1 (HectD1) and similar
                     proteins; cd21062"
                     /db_xref="CDD:439138"
     Region          2129..2606
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(2135,2164,2174,2261,2539,2571..2572,2575..2579,2599,
                     2605)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(2354,2357..2358,2360..2361,2364,2406,2408,
                     2412..2413,2415,2421,2426,2443,2447)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..2608
                     /gene="HECTD1"
                     /gene_synonym="EULIR"
                     /coded_by="XM_011536619.3:425..8251"
                     /db_xref="GeneID:25831"
                     /db_xref="HGNC:HGNC:20157"
                     /db_xref="MIM:618649"
ORIGIN      
        1 madvdpdtll ewlqmgqgde rdmqlialeq lcmlllmsdn vdrcfetcpp rtflpalcki
       61 fldesapdnv levtaraity yldvsaectr rivgvdgaik alcnrlvvve lnnrtsrdla
      121 eqcvkvleli ctresgavfe agglncvltf irdsghlvhk dtlhsamavv srlcgkmepq
      181 dssleicves lssllkhedh qvsdgalrcf asladrftrr gvdpaplakh glteellsrm
      241 aaaggtvsgp ssackpgrst tgapsttads klsnqvstiv sllstlcrgs pvvthdllrs
      301 elpdsiesal qgdercvldt mrlvdlllvl lfegrkalpk ssagstgrip glrrldssge
      361 rshrqlidci rskdtdalid aidtgafevn fmddvgqtll nwasafgtqe mveflcerga
      421 dvnrgqrsss lhyaacfgrp qvaktllrhg anpdlrdedg ktpldkarer ghsevvailq
      481 spgdwmcpvn kgddkkkkdt nkdeeecnep kgdpemapiy lkrllpvfaq tfqqtmlpsi
      541 rkaslalirk mihfcseall kevcdsdvgh nlptilveit atvldqeddd dghllalqii
      601 rdlvdkggdi fldqlarlgv iskvstlagp ssddeneees kpekedepqe dakelqqgkp
      661 yhwrdwsiir grdclyiwsd aaalelsngs ngwfrfildg klatmyssgs peggsdsses
      721 rsefleklqr argqvkpsts sqpilsapgp tkltvgnwsl tclkegeiai hnsdgqqati
      781 lkedlpgfvf esnrgtkhsf taetslgsef vtgwtgkrgr klksklektk qkvrtmardl
      841 yddhfkaves mprgvvvtlr niatqlessw elhtnrqcie sentwrdlmk talenlivll
      901 kdentispye mcssglvqal ltvlnnsmdl dmkqdcsqlv erinvfktaf seneddesrp
      961 avalirklia vlesierlpl hlydtpgsty nlqiltrrlr frlerapget alidrtgrml
     1021 kmeplatves leqyllkmva kqwydfdrss fvfvrklreg qnfifrhqhd fdengiiywi
     1081 gtnaktayew vnpaayglvv vtssegrnlp ygrledilsr dnsalnchsn ddknawfaid
     1141 lglwvipsay tlrhargygr salrnwvfqv skdgqnwtsl ythvddcsln epgstatwpl
     1201 dppkdekqgw rhvrikqmgk nasgqthyls lsgfelygtv ngvcedqlgk aakeaeanlr
     1261 rqrrlvrsqv lkymvpgarv irgldwkwrd qdgspqgegt vtgelhngwi dvtwdaggsn
     1321 syrmgaegkf dlklapgydp dtvaspkpvs stvsgttqsw sslvknncpd ktsaaagsss
     1381 rkgssssvcs vasssdislg stkterrsei vmehsivsga dvhepivvls saenvpqtev
     1441 gssssastst ltaetgsena erklgpdssv rtpgessais mgivsvsspd vssvseltnk
     1501 eaasqrplss sasnrlsvss llaagapmss sasvpnlssr etsslesfvr rvaniartna
     1561 tnnmnlsrss sdnntntlgr nvmstatspl mgaqsfpnlt tpgttstvtm stssvtsssn
     1621 vatattvlsv gqslsntltt sltstssesd tgqeaeysly dfldscrast llaelddded
     1681 lpepdeedde neddnqedqe yeeilrrpsl qrragsrsdv thhavtsqlp qvpagagsrp
     1741 igeqeeeeye tkggrrrtwd ddyvlkrqfs alvpafdprp grtnvqqttd leipppgtph
     1801 selleevect psprlaltlk vtglgttrev elpltnfrst ifyyvqkllq lscngnvksd
     1861 klrriwepty timyremkds dkekengkmg cwsiehveqy lgtdelpknd litylqknad
     1921 aaflrhwklt gtnksirknr ncsqliaayk dfcehgtksg lnqgaistlq ssdilnltke
     1981 qpqakagngq nscgvedvlq llrilyivas dpysrisqed gdeqpqftfp pdeftskkit
     2041 tkilqqieep lalasgalpd wceqltskcp flipfetrql yftctafgas raivwlqnrr
     2101 eatvertrtt ssvrrddpge frvgrlkher vkvprgeslm ewaenvmqih adrksvleve
     2161 flgeegtglg ptlefyalva aefqrtdlga wlcddnfpdd esrhvdlggg lkppgyyvqr
     2221 scglftapfp qdsdelerit klfhflgifl akciqdnrlv dlpiskpffk lmcmgdiksn
     2281 mskliyesrg drdlhctesq seasteeghd slsvgsfeed sksefildpp kpkppawfng
     2341 iltwedfelv nphrarflke ikdlaikrrq ilsnkglsed ekntklqelv lknpsgsgpp
     2401 lsiedlglnf qfcpssriyg ftavdlkpsg edemitmdna eeyvdlmfdf cmhtgiqkqm
     2461 eafrdgfnkv fpmeklssfs heevqmilcg nqspswaaed iinytepklg ytrdspgflr
     2521 fvrvlcgmss derkaflqft tgcstlppgg lanlhprltv vrkvdatdas ypsvntcvhy
     2581 lklpeyssee imrerllaat mekgfhln
//
LOCUS       XP_016876637            2563 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase HECTD1 isoform X3 [Homo sapiens].
ACCESSION   XP_016876637
VERSION     XP_016876637.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021148.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2563
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2563
                     /product="E3 ubiquitin-protein ligase HECTD1 isoform X3"
                     /calculated_mol_wt=284325
     Region          <366..>479
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          366..393
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          396..426
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(397,401..402,405..407,409..410,414,417,426,428,
                     432..433,436..438,440..441,445,448,457,459,461,465..466,
                     469..471,473..474,478)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          428..457
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          1107..1240
                     /region_name="Sad1_UNC"
                     /note="Sad1 / UNC-like C-terminal; pfam07738"
                     /db_xref="CDD:400199"
     Region          1277..>1321
                     /region_name="MIB_HERC2"
                     /note="Mib_herc2; pfam06701"
                     /db_xref="CDD:461991"
     Region          1846..1911
                     /region_name="BTHB_HectD1"
                     /note="basic tilted helix bundle (BTHB) domain found in
                     HECT domain-containing protein 1 (HectD1) and similar
                     proteins; cd21062"
                     /db_xref="CDD:439138"
     Region          2084..2561
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(2090,2119,2129,2216,2494,2526..2527,2530..2534,2554,
                     2560)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(2309,2312..2313,2315..2316,2319,2361,2363,
                     2367..2368,2370,2376,2381,2398,2402)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..2563
                     /gene="HECTD1"
                     /gene_synonym="EULIR"
                     /coded_by="XM_017021148.3:800..8491"
                     /db_xref="GeneID:25831"
                     /db_xref="HGNC:HGNC:20157"
                     /db_xref="MIM:618649"
ORIGIN      
        1 madvdpdtll ewlqmgqgde rdmqlialeq lcmlllmsdn vdrcfetcpp rtflpalcki
       61 fldesapdnv levtaraity yldvsaectr rivgvdgaik alcnrlvvve lnnrtsrdla
      121 eqcvkvleli ctresgavfe agglncvltf irdsghlvhk dtlhsamavv srlcgkmepq
      181 dssleicves lssllkhedh qvsdgalrcf asladrftrr gvdpaplakh glteellsrm
      241 aaaggtvsgp ssackpgrst tgapsttads klsnqvstiv sllstlcrgs pvvthdllrs
      301 elpdsiesal qgdercvldt mrlvdlllvl lfegrkalpk ssagstgrip glrrldssge
      361 rshrqlidci rskdtdalid aidtgafevn fmddvgqtll nwasafgtqe mveflcerga
      421 dvnrgqrsss lhyaacfgrp qvaktllrhg anpdlrdedg ktpldkarer ghsevvailq
      481 spgdwmcpvn kgddkkkkdt nkdeeecnep kgdpemapiy lkrllpvfaq tfqqtmlpsi
      541 rkaslalirk mihfcseall kevcdsdvgh nlptilveit atvldqeddd dghllalqii
      601 rdlvdkggdi fldqlarlgv iskvstlagp ssddeneees kpekedepqe dakelqqgkp
      661 yhwrdwsiir grdclyiwsd aaalelsngs ngwfrfildg klatmyssgs peggsdsses
      721 rsefleklqr argqvkpsts sqpilsapgp tkltvgnwsl tclkegeiai hnsdgqqati
      781 lkedlpgfvf esnrgtkhsf taetslgsef vtgwtgkrgr klksklektk qkvrtmardl
      841 yddhfkaves mprgvvvtlr niatqlessw elhtnrqcie sentwrdlmk talenlivll
      901 kdentispye mcssglvqal ltvlnnsmdl dmkqdcsqlv erinvfktaf seneddesrp
      961 avalirklia vlesierlpl hlydtpgsty nlqiltrrlr frlerapget alidrtgrml
     1021 kmeplatves leqyllkmva kqwydfdrss fvfvrklreg qnfifrhqhd fdengiiywi
     1081 gtnaktayew vnpaayglvv vtssegrnlp ygrledilsr dnsalnchsn ddknawfaid
     1141 lglwvipsay tlrhargygr salrnwvfqv skdgqnwtsl ythvddcsln epgstatwpl
     1201 dppkdekqgw rhvrikqmgk nasgqthyls lsgfelygtv ngvcedqlgk aakeaeanlr
     1261 rqrrlvrsqv lkymvpgarv irgldwkwrd qdgspqgegt vtgelhngtt qswsslvknn
     1321 cpdktsaaag sssrkgssss vcsvasssdi slgstkterr seivmehsiv sgadvhepiv
     1381 vlssaenvpq tevgssssas tstltaetgs enaerklgpd ssvrtpgess aismgivsvs
     1441 spdvssvsel tnkeaasqrp lsssasnrls vssllaagap msssasvpnl ssretssles
     1501 fvrrvaniar tnatnnmnls rsssdnntnt lgrnvmstat splmgaqsfp nlttpgttst
     1561 vtmstssvts ssnvatattv lsvgqslsnt lttsltstss esdtgqeaey slydfldscr
     1621 astllaeldd dedlpepdee ddeneddnqe dqeyeevmil rrpslqrrag srsdvthhav
     1681 tsqlpqvpag agsrpigeqe eeeyetkggr rrtwdddyvl krqfsalvpa fdprpgrtnv
     1741 qqttdleipp pgtphselle evectpsprl altlkvtglg ttrevelplt nfrstifyyv
     1801 qkllqlscng nvksdklrri weptytimyr emkdsdkeke ngkmgcwsie hveqylgtde
     1861 lpkndlityl qknadaaflr hwkltgtnks irknrncsql iaaykdfceh gtksglnqga
     1921 istlqssdil nltkeqpqak agngqnscgv edvlqllril yivasdpysr isqedgdeqp
     1981 qftfppdeft skkittkilq qieeplalas galpdwceql tskcpflipf etrqlyftct
     2041 afgasraivw lqnrreatve rtrttssvrr ddpgefrvgr lkhervkvpr geslmewaen
     2101 vmqihadrks vleveflgee gtglgptlef yalvaaefqr tdlgawlcdd nfpddesrhv
     2161 dlggglkppg yyvqrscglf tapfpqdsde leritklfhf lgiflakciq dnrlvdlpis
     2221 kpffklmcmg diksnmskli yesrgdrdlh ctesqseast eeghdslsvg sfeedsksef
     2281 ildppkpkpp awfngiltwe dfelvnphra rflkeikdla ikrrqilsnk glsedekntk
     2341 lqelvlknps gsgpplsied lglnfqfcps sriygftavd lkpsgedemi tmdnaeeyvd
     2401 lmfdfcmhtg iqkqmeafrd gfnkvfpmek lssfsheevq milcgnqsps waaediinyt
     2461 epklgytrds pgflrfvrvl cgmssderka flqfttgcst lppgglanlh prltvvrkvd
     2521 atdasypsvn tcvhylklpe ysseeimrer llaatmekgf hln
//
LOCUS       XP_016876638            2561 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase HECTD1 isoform X4 [Homo sapiens].
ACCESSION   XP_016876638
VERSION     XP_016876638.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021149.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2561
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2561
                     /product="E3 ubiquitin-protein ligase HECTD1 isoform X4"
                     /calculated_mol_wt=284095
     Region          <366..>479
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          366..393
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          396..426
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(397,401..402,405..407,409..410,414,417,426,428,
                     432..433,436..438,440..441,445,448,457,459,461,465..466,
                     469..471,473..474,478)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          428..457
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          1107..1240
                     /region_name="Sad1_UNC"
                     /note="Sad1 / UNC-like C-terminal; pfam07738"
                     /db_xref="CDD:400199"
     Region          1277..>1321
                     /region_name="MIB_HERC2"
                     /note="Mib_herc2; pfam06701"
                     /db_xref="CDD:461991"
     Region          1844..1909
                     /region_name="BTHB_HectD1"
                     /note="basic tilted helix bundle (BTHB) domain found in
                     HECT domain-containing protein 1 (HectD1) and similar
                     proteins; cd21062"
                     /db_xref="CDD:439138"
     Region          2082..2559
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(2088,2117,2127,2214,2492,2524..2525,2528..2532,2552,
                     2558)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(2307,2310..2311,2313..2314,2317,2359,2361,
                     2365..2366,2368,2374,2379,2396,2400)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..2561
                     /gene="HECTD1"
                     /gene_synonym="EULIR"
                     /coded_by="XM_017021149.3:800..8485"
                     /db_xref="GeneID:25831"
                     /db_xref="HGNC:HGNC:20157"
                     /db_xref="MIM:618649"
ORIGIN      
        1 madvdpdtll ewlqmgqgde rdmqlialeq lcmlllmsdn vdrcfetcpp rtflpalcki
       61 fldesapdnv levtaraity yldvsaectr rivgvdgaik alcnrlvvve lnnrtsrdla
      121 eqcvkvleli ctresgavfe agglncvltf irdsghlvhk dtlhsamavv srlcgkmepq
      181 dssleicves lssllkhedh qvsdgalrcf asladrftrr gvdpaplakh glteellsrm
      241 aaaggtvsgp ssackpgrst tgapsttads klsnqvstiv sllstlcrgs pvvthdllrs
      301 elpdsiesal qgdercvldt mrlvdlllvl lfegrkalpk ssagstgrip glrrldssge
      361 rshrqlidci rskdtdalid aidtgafevn fmddvgqtll nwasafgtqe mveflcerga
      421 dvnrgqrsss lhyaacfgrp qvaktllrhg anpdlrdedg ktpldkarer ghsevvailq
      481 spgdwmcpvn kgddkkkkdt nkdeeecnep kgdpemapiy lkrllpvfaq tfqqtmlpsi
      541 rkaslalirk mihfcseall kevcdsdvgh nlptilveit atvldqeddd dghllalqii
      601 rdlvdkggdi fldqlarlgv iskvstlagp ssddeneees kpekedepqe dakelqqgkp
      661 yhwrdwsiir grdclyiwsd aaalelsngs ngwfrfildg klatmyssgs peggsdsses
      721 rsefleklqr argqvkpsts sqpilsapgp tkltvgnwsl tclkegeiai hnsdgqqati
      781 lkedlpgfvf esnrgtkhsf taetslgsef vtgwtgkrgr klksklektk qkvrtmardl
      841 yddhfkaves mprgvvvtlr niatqlessw elhtnrqcie sentwrdlmk talenlivll
      901 kdentispye mcssglvqal ltvlnnsmdl dmkqdcsqlv erinvfktaf seneddesrp
      961 avalirklia vlesierlpl hlydtpgsty nlqiltrrlr frlerapget alidrtgrml
     1021 kmeplatves leqyllkmva kqwydfdrss fvfvrklreg qnfifrhqhd fdengiiywi
     1081 gtnaktayew vnpaayglvv vtssegrnlp ygrledilsr dnsalnchsn ddknawfaid
     1141 lglwvipsay tlrhargygr salrnwvfqv skdgqnwtsl ythvddcsln epgstatwpl
     1201 dppkdekqgw rhvrikqmgk nasgqthyls lsgfelygtv ngvcedqlgk aakeaeanlr
     1261 rqrrlvrsqv lkymvpgarv irgldwkwrd qdgspqgegt vtgelhngtt qswsslvknn
     1321 cpdktsaaag sssrkgssss vcsvasssdi slgstkterr seivmehsiv sgadvhepiv
     1381 vlssaenvpq tevgssssas tstltaetgs enaerklgpd ssvrtpgess aismgivsvs
     1441 spdvssvsel tnkeaasqrp lsssasnrls vssllaagap msssasvpnl ssretssles
     1501 fvrrvaniar tnatnnmnls rsssdnntnt lgrnvmstat splmgaqsfp nlttpgttst
     1561 vtmstssvts ssnvatattv lsvgqslsnt lttsltstss esdtgqeaey slydfldscr
     1621 astllaeldd dedlpepdee ddeneddnqe dqeyeeilrr pslqrragsr sdvthhavts
     1681 qlpqvpagag srpigeqeee eyetkggrrr twdddyvlkr qfsalvpafd prpgrtnvqq
     1741 ttdleipppg tphselleev ectpsprlal tlkvtglgtt revelpltnf rstifyyvqk
     1801 llqlscngnv ksdklrriwe ptytimyrem kdsdkekeng kmgcwsiehv eqylgtdelp
     1861 kndlitylqk nadaaflrhw kltgtnksir knrncsqlia aykdfcehgt ksglnqgais
     1921 tlqssdilnl tkeqpqakag ngqnscgved vlqllrilyi vasdpysris qedgdeqpqf
     1981 tfppdeftsk kittkilqqi eeplalasga lpdwceqlts kcpflipfet rqlyftctaf
     2041 gasraivwlq nrreatvert rttssvrrdd pgefrvgrlk hervkvprge slmewaenvm
     2101 qihadrksvl eveflgeegt glgptlefya lvaaefqrtd lgawlcddnf pddesrhvdl
     2161 ggglkppgyy vqrscglfta pfpqdsdele ritklfhflg iflakciqdn rlvdlpiskp
     2221 ffklmcmgdi ksnmskliye srgdrdlhct esqseastee ghdslsvgsf eedsksefil
     2281 dppkpkppaw fngiltwedf elvnphrarf lkeikdlaik rrqilsnkgl sedekntklq
     2341 elvlknpsgs gpplsiedlg lnfqfcpssr iygftavdlk psgedemitm dnaeeyvdlm
     2401 fdfcmhtgiq kqmeafrdgf nkvfpmekls sfsheevqmi lcgnqspswa aediinytep
     2461 klgytrdspg flrfvrvlcg mssderkafl qfttgcstlp pgglanlhpr ltvvrkvdat
     2521 dasypsvntc vhylklpeys seeimrerll aatmekgfhl n
//
LOCUS       XP_047287158            2549 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase HECTD1 isoform X5 [Homo sapiens].
ACCESSION   XP_047287158
VERSION     XP_047287158.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431202.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2549
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2549
                     /product="E3 ubiquitin-protein ligase HECTD1 isoform X5"
                     /calculated_mol_wt=282191
     Region          <366..>479
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          366..393
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          396..426
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(397,401..402,405..407,409..410,414,417,426,428,
                     432..433,436..438,440..441,445,448,457,459,461,465..466,
                     469..471,473..474,478)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          428..457
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          1107..1240
                     /region_name="Sad1_UNC"
                     /note="Sad1 / UNC-like C-terminal; pfam07738"
                     /db_xref="CDD:400199"
     Region          1277..1335
                     /region_name="MIB_HERC2"
                     /note="Mib_herc2; pfam06701"
                     /db_xref="CDD:461991"
     Region          2070..2547
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(2076,2105,2115,2202,2480,2512..2513,2516..2520,2540,
                     2546)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(2295,2298..2299,2301..2302,2305,2347,2349,
                     2353..2354,2356,2362,2367,2384,2388)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..2549
                     /gene="HECTD1"
                     /gene_synonym="EULIR"
                     /coded_by="XM_047431202.1:425..8074"
                     /db_xref="GeneID:25831"
                     /db_xref="HGNC:HGNC:20157"
                     /db_xref="MIM:618649"
ORIGIN      
        1 madvdpdtll ewlqmgqgde rdmqlialeq lcmlllmsdn vdrcfetcpp rtflpalcki
       61 fldesapdnv levtaraity yldvsaectr rivgvdgaik alcnrlvvve lnnrtsrdla
      121 eqcvkvleli ctresgavfe agglncvltf irdsghlvhk dtlhsamavv srlcgkmepq
      181 dssleicves lssllkhedh qvsdgalrcf asladrftrr gvdpaplakh glteellsrm
      241 aaaggtvsgp ssackpgrst tgapsttads klsnqvstiv sllstlcrgs pvvthdllrs
      301 elpdsiesal qgdercvldt mrlvdlllvl lfegrkalpk ssagstgrip glrrldssge
      361 rshrqlidci rskdtdalid aidtgafevn fmddvgqtll nwasafgtqe mveflcerga
      421 dvnrgqrsss lhyaacfgrp qvaktllrhg anpdlrdedg ktpldkarer ghsevvailq
      481 spgdwmcpvn kgddkkkkdt nkdeeecnep kgdpemapiy lkrllpvfaq tfqqtmlpsi
      541 rkaslalirk mihfcseall kevcdsdvgh nlptilveit atvldqeddd dghllalqii
      601 rdlvdkggdi fldqlarlgv iskvstlagp ssddeneees kpekedepqe dakelqqgkp
      661 yhwrdwsiir grdclyiwsd aaalelsngs ngwfrfildg klatmyssgs peggsdsses
      721 rsefleklqr argqvkpsts sqpilsapgp tkltvgnwsl tclkegeiai hnsdgqqati
      781 lkedlpgfvf esnrgtkhsf taetslgsef vtgwtgkrgr klksklektk qkvrtmardl
      841 yddhfkaves mprgvvvtlr niatqlessw elhtnrqcie sentwrdlmk talenlivll
      901 kdentispye mcssglvqal ltvlnnsmdl dmkqdcsqlv erinvfktaf seneddesrp
      961 avalirklia vlesierlpl hlydtpgsty nlqiltrrlr frlerapget alidrtgrml
     1021 kmeplatves leqyllkmva kqwydfdrss fvfvrklreg qnfifrhqhd fdengiiywi
     1081 gtnaktayew vnpaayglvv vtssegrnlp ygrledilsr dnsalnchsn ddknawfaid
     1141 lglwvipsay tlrhargygr salrnwvfqv skdgqnwtsl ythvddcsln epgstatwpl
     1201 dppkdekqgw rhvrikqmgk nasgqthyls lsgfelygtv ngvcedqlgk aakeaeanlr
     1261 rqrrlvrsqv lkymvpgarv irgldwkwrd qdgspqgegt vtgelhngwi dvtwdaggsn
     1321 syrmgaegkf dlklapgydp dtvaspkpvs stvsgttqsw sslvknncpd ktsaaagsss
     1381 rkgssssvcs vasssdislg stkterrsei vmehsivsga dvhepivvls saenvpqtev
     1441 gssssastst ltaetgsena erklgpdssv rtpgessais mgivsvsspd vssvseltnk
     1501 eaasqrplss sasnrlsvss llaagapmss sasvpnlssr etsslesfvr rvaniartna
     1561 tnnmnlsrss sdnntntlgr nvmstatspl mgaqsfpnlt tpgttstvtm stssvtsssn
     1621 vatattvlsv gqslsntltt sltstssesd tgqeaeysly dfldscrast llaelddded
     1681 lpepdeedde neddnqedqe yeevmilrrp slqrragsrs dvthhavtsq lpqvpagags
     1741 rpigeqeeee yetkggrrrt wdddyvlkrq fsalvpafdp rpgrtnvqqt tdleipppgt
     1801 phselleeve ctpsprlalt lkvtglgttr evelpltnfr stifyyvqkl lqlscngnvk
     1861 sdklrriwep tytimyremk dsdkekengk mdfcehgtks glnqgaistl qssdilnltk
     1921 eqpqakagng qnscgvedvl qllrilyiva sdpysrisqe dgdeqpqftf ppdeftskki
     1981 ttkilqqiee plalasgalp dwceqltskc pflipfetrq lyftctafga sraivwlqnr
     2041 reatvertrt tssvrrddpg efrvgrlkhe rvkvprgesl mewaenvmqi hadrksvlev
     2101 eflgeegtgl gptlefyalv aaefqrtdlg awlcddnfpd desrhvdlgg glkppgyyvq
     2161 rscglftapf pqdsdeleri tklfhflgif lakciqdnrl vdlpiskpff klmcmgdiks
     2221 nmskliyesr gdrdlhctes qseasteegh dslsvgsfee dsksefildp pkpkppawfn
     2281 giltwedfel vnphrarflk eikdlaikrr qilsnkglse dekntklqel vlknpsgsgp
     2341 plsiedlgln fqfcpssriy gftavdlkps gedemitmdn aeeyvdlmfd fcmhtgiqkq
     2401 meafrdgfnk vfpmeklssf sheevqmilc gnqspswaae diinytepkl gytrdspgfl
     2461 rfvrvlcgms sderkaflqf ttgcstlppg glanlhprlt vvrkvdatda sypsvntcvh
     2521 ylklpeysse eimrerllaa tmekgfhln
//
LOCUS       XP_047287160            2547 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase HECTD1 isoform X6 [Homo sapiens].
ACCESSION   XP_047287160
VERSION     XP_047287160.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431204.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2547
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2547
                     /product="E3 ubiquitin-protein ligase HECTD1 isoform X6"
                     /calculated_mol_wt=281960
     Region          <366..>479
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          366..393
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          396..426
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(397,401..402,405..407,409..410,414,417,426,428,
                     432..433,436..438,440..441,445,448,457,459,461,465..466,
                     469..471,473..474,478)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          428..457
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          1107..1240
                     /region_name="Sad1_UNC"
                     /note="Sad1 / UNC-like C-terminal; pfam07738"
                     /db_xref="CDD:400199"
     Region          1277..1335
                     /region_name="MIB_HERC2"
                     /note="Mib_herc2; pfam06701"
                     /db_xref="CDD:461991"
     Region          2068..2545
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(2074,2103,2113,2200,2478,2510..2511,2514..2518,2538,
                     2544)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(2293,2296..2297,2299..2300,2303,2345,2347,
                     2351..2352,2354,2360,2365,2382,2386)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..2547
                     /gene="HECTD1"
                     /gene_synonym="EULIR"
                     /coded_by="XM_047431204.1:425..8068"
                     /db_xref="GeneID:25831"
                     /db_xref="HGNC:HGNC:20157"
                     /db_xref="MIM:618649"
ORIGIN      
        1 madvdpdtll ewlqmgqgde rdmqlialeq lcmlllmsdn vdrcfetcpp rtflpalcki
       61 fldesapdnv levtaraity yldvsaectr rivgvdgaik alcnrlvvve lnnrtsrdla
      121 eqcvkvleli ctresgavfe agglncvltf irdsghlvhk dtlhsamavv srlcgkmepq
      181 dssleicves lssllkhedh qvsdgalrcf asladrftrr gvdpaplakh glteellsrm
      241 aaaggtvsgp ssackpgrst tgapsttads klsnqvstiv sllstlcrgs pvvthdllrs
      301 elpdsiesal qgdercvldt mrlvdlllvl lfegrkalpk ssagstgrip glrrldssge
      361 rshrqlidci rskdtdalid aidtgafevn fmddvgqtll nwasafgtqe mveflcerga
      421 dvnrgqrsss lhyaacfgrp qvaktllrhg anpdlrdedg ktpldkarer ghsevvailq
      481 spgdwmcpvn kgddkkkkdt nkdeeecnep kgdpemapiy lkrllpvfaq tfqqtmlpsi
      541 rkaslalirk mihfcseall kevcdsdvgh nlptilveit atvldqeddd dghllalqii
      601 rdlvdkggdi fldqlarlgv iskvstlagp ssddeneees kpekedepqe dakelqqgkp
      661 yhwrdwsiir grdclyiwsd aaalelsngs ngwfrfildg klatmyssgs peggsdsses
      721 rsefleklqr argqvkpsts sqpilsapgp tkltvgnwsl tclkegeiai hnsdgqqati
      781 lkedlpgfvf esnrgtkhsf taetslgsef vtgwtgkrgr klksklektk qkvrtmardl
      841 yddhfkaves mprgvvvtlr niatqlessw elhtnrqcie sentwrdlmk talenlivll
      901 kdentispye mcssglvqal ltvlnnsmdl dmkqdcsqlv erinvfktaf seneddesrp
      961 avalirklia vlesierlpl hlydtpgsty nlqiltrrlr frlerapget alidrtgrml
     1021 kmeplatves leqyllkmva kqwydfdrss fvfvrklreg qnfifrhqhd fdengiiywi
     1081 gtnaktayew vnpaayglvv vtssegrnlp ygrledilsr dnsalnchsn ddknawfaid
     1141 lglwvipsay tlrhargygr salrnwvfqv skdgqnwtsl ythvddcsln epgstatwpl
     1201 dppkdekqgw rhvrikqmgk nasgqthyls lsgfelygtv ngvcedqlgk aakeaeanlr
     1261 rqrrlvrsqv lkymvpgarv irgldwkwrd qdgspqgegt vtgelhngwi dvtwdaggsn
     1321 syrmgaegkf dlklapgydp dtvaspkpvs stvsgttqsw sslvknncpd ktsaaagsss
     1381 rkgssssvcs vasssdislg stkterrsei vmehsivsga dvhepivvls saenvpqtev
     1441 gssssastst ltaetgsena erklgpdssv rtpgessais mgivsvsspd vssvseltnk
     1501 eaasqrplss sasnrlsvss llaagapmss sasvpnlssr etsslesfvr rvaniartna
     1561 tnnmnlsrss sdnntntlgr nvmstatspl mgaqsfpnlt tpgttstvtm stssvtsssn
     1621 vatattvlsv gqslsntltt sltstssesd tgqeaeysly dfldscrast llaelddded
     1681 lpepdeedde neddnqedqe yeeilrrpsl qrragsrsdv thhavtsqlp qvpagagsrp
     1741 igeqeeeeye tkggrrrtwd ddyvlkrqfs alvpafdprp grtnvqqttd leipppgtph
     1801 selleevect psprlaltlk vtglgttrev elpltnfrst ifyyvqkllq lscngnvksd
     1861 klrriwepty timyremkds dkekengkmd fcehgtksgl nqgaistlqs sdilnltkeq
     1921 pqakagngqn scgvedvlql lrilyivasd pysrisqedg deqpqftfpp deftskkitt
     1981 kilqqieepl alasgalpdw ceqltskcpf lipfetrqly ftctafgasr aivwlqnrre
     2041 atvertrtts svrrddpgef rvgrlkherv kvprgeslme waenvmqiha drksvlevef
     2101 lgeegtglgp tlefyalvaa efqrtdlgaw lcddnfpdde srhvdlgggl kppgyyvqrs
     2161 cglftapfpq dsdeleritk lfhflgifla kciqdnrlvd lpiskpffkl mcmgdiksnm
     2221 skliyesrgd rdlhctesqs easteeghds lsvgsfeeds ksefildppk pkppawfngi
     2281 ltwedfelvn phrarflkei kdlaikrrqi lsnkglsede kntklqelvl knpsgsgppl
     2341 siedlglnfq fcpssriygf tavdlkpsge demitmdnae eyvdlmfdfc mhtgiqkqme
     2401 afrdgfnkvf pmeklssfsh eevqmilcgn qspswaaedi inytepklgy trdspgflrf
     2461 vrvlcgmssd erkaflqftt gcstlppggl anlhprltvv rkvdatdasy psvntcvhyl
     2521 klpeysseei mrerllaatm ekgfhln
//
LOCUS       XP_047287162            2502 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase HECTD1 isoform X7 [Homo sapiens].
ACCESSION   XP_047287162
VERSION     XP_047287162.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431206.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2502
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2502
                     /product="E3 ubiquitin-protein ligase HECTD1 isoform X7"
                     /calculated_mol_wt=277277
     Region          <366..>479
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          366..393
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          396..426
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(397,401..402,405..407,409..410,414,417,426,428,
                     432..433,436..438,440..441,445,448,457,459,461,465..466,
                     469..471,473..474,478)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          428..457
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          1107..1240
                     /region_name="Sad1_UNC"
                     /note="Sad1 / UNC-like C-terminal; pfam07738"
                     /db_xref="CDD:400199"
     Region          1277..>1321
                     /region_name="MIB_HERC2"
                     /note="Mib_herc2; pfam06701"
                     /db_xref="CDD:461991"
     Region          2023..2500
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(2029,2058,2068,2155,2433,2465..2466,2469..2473,2493,
                     2499)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(2248,2251..2252,2254..2255,2258,2300,2302,
                     2306..2307,2309,2315,2320,2337,2341)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..2502
                     /gene="HECTD1"
                     /gene_synonym="EULIR"
                     /coded_by="XM_047431206.1:425..7933"
                     /db_xref="GeneID:25831"
                     /db_xref="HGNC:HGNC:20157"
                     /db_xref="MIM:618649"
ORIGIN      
        1 madvdpdtll ewlqmgqgde rdmqlialeq lcmlllmsdn vdrcfetcpp rtflpalcki
       61 fldesapdnv levtaraity yldvsaectr rivgvdgaik alcnrlvvve lnnrtsrdla
      121 eqcvkvleli ctresgavfe agglncvltf irdsghlvhk dtlhsamavv srlcgkmepq
      181 dssleicves lssllkhedh qvsdgalrcf asladrftrr gvdpaplakh glteellsrm
      241 aaaggtvsgp ssackpgrst tgapsttads klsnqvstiv sllstlcrgs pvvthdllrs
      301 elpdsiesal qgdercvldt mrlvdlllvl lfegrkalpk ssagstgrip glrrldssge
      361 rshrqlidci rskdtdalid aidtgafevn fmddvgqtll nwasafgtqe mveflcerga
      421 dvnrgqrsss lhyaacfgrp qvaktllrhg anpdlrdedg ktpldkarer ghsevvailq
      481 spgdwmcpvn kgddkkkkdt nkdeeecnep kgdpemapiy lkrllpvfaq tfqqtmlpsi
      541 rkaslalirk mihfcseall kevcdsdvgh nlptilveit atvldqeddd dghllalqii
      601 rdlvdkggdi fldqlarlgv iskvstlagp ssddeneees kpekedepqe dakelqqgkp
      661 yhwrdwsiir grdclyiwsd aaalelsngs ngwfrfildg klatmyssgs peggsdsses
      721 rsefleklqr argqvkpsts sqpilsapgp tkltvgnwsl tclkegeiai hnsdgqqati
      781 lkedlpgfvf esnrgtkhsf taetslgsef vtgwtgkrgr klksklektk qkvrtmardl
      841 yddhfkaves mprgvvvtlr niatqlessw elhtnrqcie sentwrdlmk talenlivll
      901 kdentispye mcssglvqal ltvlnnsmdl dmkqdcsqlv erinvfktaf seneddesrp
      961 avalirklia vlesierlpl hlydtpgsty nlqiltrrlr frlerapget alidrtgrml
     1021 kmeplatves leqyllkmva kqwydfdrss fvfvrklreg qnfifrhqhd fdengiiywi
     1081 gtnaktayew vnpaayglvv vtssegrnlp ygrledilsr dnsalnchsn ddknawfaid
     1141 lglwvipsay tlrhargygr salrnwvfqv skdgqnwtsl ythvddcsln epgstatwpl
     1201 dppkdekqgw rhvrikqmgk nasgqthyls lsgfelygtv ngvcedqlgk aakeaeanlr
     1261 rqrrlvrsqv lkymvpgarv irgldwkwrd qdgspqgegt vtgelhngtt qswsslvknn
     1321 cpdktsaaag sssrkgssss vcsvasssdi slgstkterr seivmehsiv sgadvhepiv
     1381 vlssaenvpq tevgssssas tstltaetgs enaerklgpd ssvrtpgess aismgivsvs
     1441 spdvssvsel tnkeaasqrp lsssasnrls vssllaagap msssasvpnl ssretssles
     1501 fvrrvaniar tnatnnmnls rsssdnntnt lgrnvmstat splmgaqsfp nlttpgttst
     1561 vtmstssvts ssnvatattv lsvgqslsnt lttsltstss esdtgqeaey slydfldscr
     1621 astllaeldd dedlpepdee ddeneddnqe dqeyeevmil rrpslqrrag srsdvthhav
     1681 tsqlpqvpag agsrpigeqe eeeyetkggr rrtwdddyvl krqfsalvpa fdprpgrtnv
     1741 qqttdleipp pgtphselle evectpsprl altlkvtglg ttrevelplt nfrstifyyv
     1801 qkllqlscng nvksdklrri weptytimyr emkdsdkeke ngkmdfcehg tksglnqgai
     1861 stlqssdiln ltkeqpqaka gngqnscgve dvlqllrily ivasdpysri sqedgdeqpq
     1921 ftfppdefts kkittkilqq ieeplalasg alpdwceqlt skcpflipfe trqlyftcta
     1981 fgasraivwl qnrreatver trttssvrrd dpgefrvgrl khervkvprg eslmewaenv
     2041 mqihadrksv leveflgeeg tglgptlefy alvaaefqrt dlgawlcddn fpddesrhvd
     2101 lggglkppgy yvqrscglft apfpqdsdel eritklfhfl giflakciqd nrlvdlpisk
     2161 pffklmcmgd iksnmskliy esrgdrdlhc tesqseaste eghdslsvgs feedsksefi
     2221 ldppkpkppa wfngiltwed felvnphrar flkeikdlai krrqilsnkg lsedekntkl
     2281 qelvlknpsg sgpplsiedl glnfqfcpss riygftavdl kpsgedemit mdnaeeyvdl
     2341 mfdfcmhtgi qkqmeafrdg fnkvfpmekl ssfsheevqm ilcgnqspsw aaediinyte
     2401 pklgytrdsp gflrfvrvlc gmssderkaf lqfttgcstl ppgglanlhp rltvvrkvda
     2461 tdasypsvnt cvhylklpey sseeimrerl laatmekgfh ln
//
LOCUS       XP_011534923            2331 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase HECTD1 isoform X9 [Homo sapiens].
ACCESSION   XP_011534923
VERSION     XP_011534923.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536621.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2331
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2331
                     /product="E3 ubiquitin-protein ligase HECTD1 isoform X9"
                     /calculated_mol_wt=260688
     Region          <366..>479
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          366..393
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          396..426
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(397,401..402,405..407,409..410,414,417,426,428,
                     432..433,436..438,440..441,445,448,457,459,461,465..466,
                     469..471,473..474,478)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          428..457
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          1107..1240
                     /region_name="Sad1_UNC"
                     /note="Sad1 / UNC-like C-terminal; pfam07738"
                     /db_xref="CDD:400199"
     Region          1277..>1302
                     /region_name="MIB_HERC2"
                     /note="Mib_herc2; pfam06701"
                     /db_xref="CDD:461991"
     Region          1614..1679
                     /region_name="BTHB_HectD1"
                     /note="basic tilted helix bundle (BTHB) domain found in
                     HECT domain-containing protein 1 (HectD1) and similar
                     proteins; cd21062"
                     /db_xref="CDD:439138"
     Region          1852..2329
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(1858,1887,1897,1984,2262,2294..2295,2298..2302,2322,
                     2328)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(2077,2080..2081,2083..2084,2087,2129,2131,
                     2135..2136,2138,2144,2149,2166,2170)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..2331
                     /gene="HECTD1"
                     /gene_synonym="EULIR"
                     /coded_by="XM_011536621.3:425..7420"
                     /db_xref="GeneID:25831"
                     /db_xref="HGNC:HGNC:20157"
                     /db_xref="MIM:618649"
ORIGIN      
        1 madvdpdtll ewlqmgqgde rdmqlialeq lcmlllmsdn vdrcfetcpp rtflpalcki
       61 fldesapdnv levtaraity yldvsaectr rivgvdgaik alcnrlvvve lnnrtsrdla
      121 eqcvkvleli ctresgavfe agglncvltf irdsghlvhk dtlhsamavv srlcgkmepq
      181 dssleicves lssllkhedh qvsdgalrcf asladrftrr gvdpaplakh glteellsrm
      241 aaaggtvsgp ssackpgrst tgapsttads klsnqvstiv sllstlcrgs pvvthdllrs
      301 elpdsiesal qgdercvldt mrlvdlllvl lfegrkalpk ssagstgrip glrrldssge
      361 rshrqlidci rskdtdalid aidtgafevn fmddvgqtll nwasafgtqe mveflcerga
      421 dvnrgqrsss lhyaacfgrp qvaktllrhg anpdlrdedg ktpldkarer ghsevvailq
      481 spgdwmcpvn kgddkkkkdt nkdeeecnep kgdpemapiy lkrllpvfaq tfqqtmlpsi
      541 rkaslalirk mihfcseall kevcdsdvgh nlptilveit atvldqeddd dghllalqii
      601 rdlvdkggdi fldqlarlgv iskvstlagp ssddeneees kpekedepqe dakelqqgkp
      661 yhwrdwsiir grdclyiwsd aaalelsngs ngwfrfildg klatmyssgs peggsdsses
      721 rsefleklqr argqvkpsts sqpilsapgp tkltvgnwsl tclkegeiai hnsdgqqati
      781 lkedlpgfvf esnrgtkhsf taetslgsef vtgwtgkrgr klksklektk qkvrtmardl
      841 yddhfkaves mprgvvvtlr niatqlessw elhtnrqcie sentwrdlmk talenlivll
      901 kdentispye mcssglvqal ltvlnnsmdl dmkqdcsqlv erinvfktaf seneddesrp
      961 avalirklia vlesierlpl hlydtpgsty nlqiltrrlr frlerapget alidrtgrml
     1021 kmeplatves leqyllkmva kqwydfdrss fvfvrklreg qnfifrhqhd fdengiiywi
     1081 gtnaktayew vnpaayglvv vtssegrnlp ygrledilsr dnsalnchsn ddknawfaid
     1141 lglwvipsay tlrhargygr salrnwvfqv skdgqnwtsl ythvddcsln epgstatwpl
     1201 dppkdekqgw rhvrikqmgk nasgqthyls lsgfelygtv ngvcedqlgk aakeaeanlr
     1261 rqrrlvrsqv lkymvpgarv irgldwkwrd qdgspqgegt vtgelhnasp lmgaqsfpnl
     1321 ttpgttstvt mstssvtsss nvatattvls vgqslsntlt tsltstsses dtgqeaeysl
     1381 ydfldscras tllaelddde dlpepdeedd eneddnqedq eyeevmilrr pslqrragsr
     1441 sdvthhavts qlpqvpagag srpigeqeee eyetkggrrr twdddyvlkr qfsalvpafd
     1501 prpgrtnvqq ttdleipppg tphselleev ectpsprlal tlkvtglgtt revelpltnf
     1561 rstifyyvqk llqlscngnv ksdklrriwe ptytimyrem kdsdkekeng kmgcwsiehv
     1621 eqylgtdelp kndlitylqk nadaaflrhw kltgtnksir knrncsqlia aykdfcehgt
     1681 ksglnqgais tlqssdilnl tkeqpqakag ngqnscgved vlqllrilyi vasdpysris
     1741 qedgdeqpqf tfppdeftsk kittkilqqi eeplalasga lpdwceqlts kcpflipfet
     1801 rqlyftctaf gasraivwlq nrreatvert rttssvrrdd pgefrvgrlk hervkvprge
     1861 slmewaenvm qihadrksvl eveflgeegt glgptlefya lvaaefqrtd lgawlcddnf
     1921 pddesrhvdl ggglkppgyy vqrscglfta pfpqdsdele ritklfhflg iflakciqdn
     1981 rlvdlpiskp ffklmcmgdi ksnmskliye srgdrdlhct esqseastee ghdslsvgsf
     2041 eedsksefil dppkpkppaw fngiltwedf elvnphrarf lkeikdlaik rrqilsnkgl
     2101 sedekntklq elvlknpsgs gpplsiedlg lnfqfcpssr iygftavdlk psgedemitm
     2161 dnaeeyvdlm fdfcmhtgiq kqmeafrdgf nkvfpmekls sfsheevqmi lcgnqspswa
     2221 aediinytep klgytrdspg flrfvrvlcg mssderkafl qfttgcstlp pgglanlhpr
     2281 ltvvrkvdat dasypsvntc vhylklpeys seeimrerll aatmekgfhl n
//
LOCUS       XP_016876642            2329 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase HECTD1 isoform X10 [Homo sapiens].
ACCESSION   XP_016876642
VERSION     XP_016876642.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021153.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2329
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2329
                     /product="E3 ubiquitin-protein ligase HECTD1 isoform X10"
                     /calculated_mol_wt=260458
     Region          <366..>479
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          366..393
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          396..426
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(397,401..402,405..407,409..410,414,417,426,428,
                     432..433,436..438,440..441,445,448,457,459,461,465..466,
                     469..471,473..474,478)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          428..457
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          1107..1240
                     /region_name="Sad1_UNC"
                     /note="Sad1 / UNC-like C-terminal; pfam07738"
                     /db_xref="CDD:400199"
     Region          1277..>1302
                     /region_name="MIB_HERC2"
                     /note="Mib_herc2; pfam06701"
                     /db_xref="CDD:461991"
     Region          1612..1677
                     /region_name="BTHB_HectD1"
                     /note="basic tilted helix bundle (BTHB) domain found in
                     HECT domain-containing protein 1 (HectD1) and similar
                     proteins; cd21062"
                     /db_xref="CDD:439138"
     Region          1850..2327
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(1856,1885,1895,1982,2260,2292..2293,2296..2300,2320,
                     2326)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(2075,2078..2079,2081..2082,2085,2127,2129,
                     2133..2134,2136,2142,2147,2164,2168)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..2329
                     /gene="HECTD1"
                     /gene_synonym="EULIR"
                     /coded_by="XM_017021153.2:425..7414"
                     /db_xref="GeneID:25831"
                     /db_xref="HGNC:HGNC:20157"
                     /db_xref="MIM:618649"
ORIGIN      
        1 madvdpdtll ewlqmgqgde rdmqlialeq lcmlllmsdn vdrcfetcpp rtflpalcki
       61 fldesapdnv levtaraity yldvsaectr rivgvdgaik alcnrlvvve lnnrtsrdla
      121 eqcvkvleli ctresgavfe agglncvltf irdsghlvhk dtlhsamavv srlcgkmepq
      181 dssleicves lssllkhedh qvsdgalrcf asladrftrr gvdpaplakh glteellsrm
      241 aaaggtvsgp ssackpgrst tgapsttads klsnqvstiv sllstlcrgs pvvthdllrs
      301 elpdsiesal qgdercvldt mrlvdlllvl lfegrkalpk ssagstgrip glrrldssge
      361 rshrqlidci rskdtdalid aidtgafevn fmddvgqtll nwasafgtqe mveflcerga
      421 dvnrgqrsss lhyaacfgrp qvaktllrhg anpdlrdedg ktpldkarer ghsevvailq
      481 spgdwmcpvn kgddkkkkdt nkdeeecnep kgdpemapiy lkrllpvfaq tfqqtmlpsi
      541 rkaslalirk mihfcseall kevcdsdvgh nlptilveit atvldqeddd dghllalqii
      601 rdlvdkggdi fldqlarlgv iskvstlagp ssddeneees kpekedepqe dakelqqgkp
      661 yhwrdwsiir grdclyiwsd aaalelsngs ngwfrfildg klatmyssgs peggsdsses
      721 rsefleklqr argqvkpsts sqpilsapgp tkltvgnwsl tclkegeiai hnsdgqqati
      781 lkedlpgfvf esnrgtkhsf taetslgsef vtgwtgkrgr klksklektk qkvrtmardl
      841 yddhfkaves mprgvvvtlr niatqlessw elhtnrqcie sentwrdlmk talenlivll
      901 kdentispye mcssglvqal ltvlnnsmdl dmkqdcsqlv erinvfktaf seneddesrp
      961 avalirklia vlesierlpl hlydtpgsty nlqiltrrlr frlerapget alidrtgrml
     1021 kmeplatves leqyllkmva kqwydfdrss fvfvrklreg qnfifrhqhd fdengiiywi
     1081 gtnaktayew vnpaayglvv vtssegrnlp ygrledilsr dnsalnchsn ddknawfaid
     1141 lglwvipsay tlrhargygr salrnwvfqv skdgqnwtsl ythvddcsln epgstatwpl
     1201 dppkdekqgw rhvrikqmgk nasgqthyls lsgfelygtv ngvcedqlgk aakeaeanlr
     1261 rqrrlvrsqv lkymvpgarv irgldwkwrd qdgspqgegt vtgelhnasp lmgaqsfpnl
     1321 ttpgttstvt mstssvtsss nvatattvls vgqslsntlt tsltstsses dtgqeaeysl
     1381 ydfldscras tllaelddde dlpepdeedd eneddnqedq eyeeilrrps lqrragsrsd
     1441 vthhavtsql pqvpagagsr pigeqeeeey etkggrrrtw dddyvlkrqf salvpafdpr
     1501 pgrtnvqqtt dleipppgtp hselleevec tpsprlaltl kvtglgttre velpltnfrs
     1561 tifyyvqkll qlscngnvks dklrriwept ytimyremkd sdkekengkm gcwsiehveq
     1621 ylgtdelpkn dlitylqkna daaflrhwkl tgtnksirkn rncsqliaay kdfcehgtks
     1681 glnqgaistl qssdilnltk eqpqakagng qnscgvedvl qllrilyiva sdpysrisqe
     1741 dgdeqpqftf ppdeftskki ttkilqqiee plalasgalp dwceqltskc pflipfetrq
     1801 lyftctafga sraivwlqnr reatvertrt tssvrrddpg efrvgrlkhe rvkvprgesl
     1861 mewaenvmqi hadrksvlev eflgeegtgl gptlefyalv aaefqrtdlg awlcddnfpd
     1921 desrhvdlgg glkppgyyvq rscglftapf pqdsdeleri tklfhflgif lakciqdnrl
     1981 vdlpiskpff klmcmgdiks nmskliyesr gdrdlhctes qseasteegh dslsvgsfee
     2041 dsksefildp pkpkppawfn giltwedfel vnphrarflk eikdlaikrr qilsnkglse
     2101 dekntklqel vlknpsgsgp plsiedlgln fqfcpssriy gftavdlkps gedemitmdn
     2161 aeeyvdlmfd fcmhtgiqkq meafrdgfnk vfpmeklssf sheevqmilc gnqspswaae
     2221 diinytepkl gytrdspgfl rfvrvlcgms sderkaflqf ttgcstlppg glanlhprlt
     2281 vvrkvdatda sypsvntcvh ylklpeysse eimrerllaa tmekgfhln
//
LOCUS       XP_047287164            2270 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase HECTD1 isoform X11 [Homo sapiens].
ACCESSION   XP_047287164
VERSION     XP_047287164.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431208.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2270
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2270
                     /product="E3 ubiquitin-protein ligase HECTD1 isoform X11"
                     /calculated_mol_wt=253640
     Region          <366..>479
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          366..393
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          396..426
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(397,401..402,405..407,409..410,414,417,426,428,
                     432..433,436..438,440..441,445,448,457,459,461,465..466,
                     469..471,473..474,478)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          428..457
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          1107..1240
                     /region_name="Sad1_UNC"
                     /note="Sad1 / UNC-like C-terminal; pfam07738"
                     /db_xref="CDD:400199"
     Region          1277..>1302
                     /region_name="MIB_HERC2"
                     /note="Mib_herc2; pfam06701"
                     /db_xref="CDD:461991"
     Region          1791..2268
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(1797,1826,1836,1923,2201,2233..2234,2237..2241,2261,
                     2267)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(2016,2019..2020,2022..2023,2026,2068,2070,
                     2074..2075,2077,2083,2088,2105,2109)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..2270
                     /gene="HECTD1"
                     /gene_synonym="EULIR"
                     /coded_by="XM_047431208.1:425..7237"
                     /db_xref="GeneID:25831"
                     /db_xref="HGNC:HGNC:20157"
                     /db_xref="MIM:618649"
ORIGIN      
        1 madvdpdtll ewlqmgqgde rdmqlialeq lcmlllmsdn vdrcfetcpp rtflpalcki
       61 fldesapdnv levtaraity yldvsaectr rivgvdgaik alcnrlvvve lnnrtsrdla
      121 eqcvkvleli ctresgavfe agglncvltf irdsghlvhk dtlhsamavv srlcgkmepq
      181 dssleicves lssllkhedh qvsdgalrcf asladrftrr gvdpaplakh glteellsrm
      241 aaaggtvsgp ssackpgrst tgapsttads klsnqvstiv sllstlcrgs pvvthdllrs
      301 elpdsiesal qgdercvldt mrlvdlllvl lfegrkalpk ssagstgrip glrrldssge
      361 rshrqlidci rskdtdalid aidtgafevn fmddvgqtll nwasafgtqe mveflcerga
      421 dvnrgqrsss lhyaacfgrp qvaktllrhg anpdlrdedg ktpldkarer ghsevvailq
      481 spgdwmcpvn kgddkkkkdt nkdeeecnep kgdpemapiy lkrllpvfaq tfqqtmlpsi
      541 rkaslalirk mihfcseall kevcdsdvgh nlptilveit atvldqeddd dghllalqii
      601 rdlvdkggdi fldqlarlgv iskvstlagp ssddeneees kpekedepqe dakelqqgkp
      661 yhwrdwsiir grdclyiwsd aaalelsngs ngwfrfildg klatmyssgs peggsdsses
      721 rsefleklqr argqvkpsts sqpilsapgp tkltvgnwsl tclkegeiai hnsdgqqati
      781 lkedlpgfvf esnrgtkhsf taetslgsef vtgwtgkrgr klksklektk qkvrtmardl
      841 yddhfkaves mprgvvvtlr niatqlessw elhtnrqcie sentwrdlmk talenlivll
      901 kdentispye mcssglvqal ltvlnnsmdl dmkqdcsqlv erinvfktaf seneddesrp
      961 avalirklia vlesierlpl hlydtpgsty nlqiltrrlr frlerapget alidrtgrml
     1021 kmeplatves leqyllkmva kqwydfdrss fvfvrklreg qnfifrhqhd fdengiiywi
     1081 gtnaktayew vnpaayglvv vtssegrnlp ygrledilsr dnsalnchsn ddknawfaid
     1141 lglwvipsay tlrhargygr salrnwvfqv skdgqnwtsl ythvddcsln epgstatwpl
     1201 dppkdekqgw rhvrikqmgk nasgqthyls lsgfelygtv ngvcedqlgk aakeaeanlr
     1261 rqrrlvrsqv lkymvpgarv irgldwkwrd qdgspqgegt vtgelhnasp lmgaqsfpnl
     1321 ttpgttstvt mstssvtsss nvatattvls vgqslsntlt tsltstsses dtgqeaeysl
     1381 ydfldscras tllaelddde dlpepdeedd eneddnqedq eyeevmilrr pslqrragsr
     1441 sdvthhavts qlpqvpagag srpigeqeee eyetkggrrr twdddyvlkr qfsalvpafd
     1501 prpgrtnvqq ttdleipppg tphselleev ectpsprlal tlkvtglgtt revelpltnf
     1561 rstifyyvqk llqlscngnv ksdklrriwe ptytimyrem kdsdkekeng kmdfcehgtk
     1621 sglnqgaist lqssdilnlt keqpqakagn gqnscgvedv lqllrilyiv asdpysrisq
     1681 edgdeqpqft fppdeftskk ittkilqqie eplalasgal pdwceqltsk cpflipfetr
     1741 qlyftctafg asraivwlqn rreatvertr ttssvrrddp gefrvgrlkh ervkvprges
     1801 lmewaenvmq ihadrksvle veflgeegtg lgptlefyal vaaefqrtdl gawlcddnfp
     1861 ddesrhvdlg gglkppgyyv qrscglftap fpqdsdeler itklfhflgi flakciqdnr
     1921 lvdlpiskpf fklmcmgdik snmskliyes rgdrdlhcte sqseasteeg hdslsvgsfe
     1981 edsksefild ppkpkppawf ngiltwedfe lvnphrarfl keikdlaikr rqilsnkgls
     2041 edekntklqe lvlknpsgsg pplsiedlgl nfqfcpssri ygftavdlkp sgedemitmd
     2101 naeeyvdlmf dfcmhtgiqk qmeafrdgfn kvfpmeklss fsheevqmil cgnqspswaa
     2161 ediinytepk lgytrdspgf lrfvrvlcgm ssderkaflq fttgcstlpp gglanlhprl
     2221 tvvrkvdatd asypsvntcv hylklpeyss eeimrerlla atmekgfhln
//
LOCUS       XP_011534924            2060 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase HECTD1 isoform X12 [Homo sapiens].
ACCESSION   XP_011534924
VERSION     XP_011534924.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536622.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2060
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2060
                     /product="E3 ubiquitin-protein ligase HECTD1 isoform X12"
                     /calculated_mol_wt=229072
     Region          557..690
                     /region_name="Sad1_UNC"
                     /note="Sad1 / UNC-like C-terminal; pfam07738"
                     /db_xref="CDD:400199"
     Region          727..785
                     /region_name="MIB_HERC2"
                     /note="Mib_herc2; pfam06701"
                     /db_xref="CDD:461991"
     Region          1343..1408
                     /region_name="BTHB_HectD1"
                     /note="basic tilted helix bundle (BTHB) domain found in
                     HECT domain-containing protein 1 (HectD1) and similar
                     proteins; cd21062"
                     /db_xref="CDD:439138"
     Region          1581..2058
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(1587,1616,1626,1713,1991,2023..2024,2027..2031,2051,
                     2057)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(1806,1809..1810,1812..1813,1816,1858,1860,
                     1864..1865,1867,1873,1878,1895,1899)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..2060
                     /gene="HECTD1"
                     /gene_synonym="EULIR"
                     /coded_by="XM_011536622.2:106..6288"
                     /db_xref="GeneID:25831"
                     /db_xref="HGNC:HGNC:20157"
                     /db_xref="MIM:618649"
ORIGIN      
        1 mihfcseall kevcdsdvgh nlptilveit atvldqeddd dghllalqii rdlvdkggdi
       61 fldqlarlgv iskvstlagp ssddeneees kpekedepqe dakelqqgkp yhwrdwsiir
      121 grdclyiwsd aaalelsngs ngwfrfildg klatmyssgs peggsdsses rsefleklqr
      181 argqvkpsts sqpilsapgp tkltvgnwsl tclkegeiai hnsdgqqati lkedlpgfvf
      241 esnrgtkhsf taetslgsef vtgwtgkrgr klksklektk qkvrtmardl yddhfkaves
      301 mprgvvvtlr niatqlessw elhtnrqcie sentwrdlmk talenlivll kdentispye
      361 mcssglvqal ltvlnnsmdl dmkqdcsqlv erinvfktaf seneddesrp avalirklia
      421 vlesierlpl hlydtpgsty nlqiltrrlr frlerapget alidrtgrml kmeplatves
      481 leqyllkmva kqwydfdrss fvfvrklreg qnfifrhqhd fdengiiywi gtnaktayew
      541 vnpaayglvv vtssegrnlp ygrledilsr dnsalnchsn ddknawfaid lglwvipsay
      601 tlrhargygr salrnwvfqv skdgqnwtsl ythvddcsln epgstatwpl dppkdekqgw
      661 rhvrikqmgk nasgqthyls lsgfelygtv ngvcedqlgk aakeaeanlr rqrrlvrsqv
      721 lkymvpgarv irgldwkwrd qdgspqgegt vtgelhngwi dvtwdaggsn syrmgaegkf
      781 dlklapgydp dtvaspkpvs stvsgttqsw sslvknncpd ktsaaagsss rkgssssvcs
      841 vasssdislg stkterrsei vmehsivsga dvhepivvls saenvpqtev gssssastst
      901 ltaetgsena erklgpdssv rtpgessais mgivsvsspd vssvseltnk eaasqrplss
      961 sasnrlsvss llaagapmss sasvpnlssr etsslesfvr rvaniartna tnnmnlsrss
     1021 sdnntntlgr nvmstatspl mgaqsfpnlt tpgttstvtm stssvtsssn vatattvlsv
     1081 gqslsntltt sltstssesd tgqeaeysly dfldscrast llaelddded lpepdeedde
     1141 neddnqedqe yeevmilrrp slqrragsrs dvthhavtsq lpqvpagags rpigeqeeee
     1201 yetkggrrrt wdddyvlkrq fsalvpafdp rpgrtnvqqt tdleipppgt phselleeve
     1261 ctpsprlalt lkvtglgttr evelpltnfr stifyyvqkl lqlscngnvk sdklrriwep
     1321 tytimyremk dsdkekengk mgcwsiehve qylgtdelpk ndlitylqkn adaaflrhwk
     1381 ltgtnksirk nrncsqliaa ykdfcehgtk sglnqgaist lqssdilnlt keqpqakagn
     1441 gqnscgvedv lqllrilyiv asdpysrisq edgdeqpqft fppdeftskk ittkilqqie
     1501 eplalasgal pdwceqltsk cpflipfetr qlyftctafg asraivwlqn rreatvertr
     1561 ttssvrrddp gefrvgrlkh ervkvprges lmewaenvmq ihadrksvle veflgeegtg
     1621 lgptlefyal vaaefqrtdl gawlcddnfp ddesrhvdlg gglkppgyyv qrscglftap
     1681 fpqdsdeler itklfhflgi flakciqdnr lvdlpiskpf fklmcmgdik snmskliyes
     1741 rgdrdlhcte sqseasteeg hdslsvgsfe edsksefild ppkpkppawf ngiltwedfe
     1801 lvnphrarfl keikdlaikr rqilsnkgls edekntklqe lvlknpsgsg pplsiedlgl
     1861 nfqfcpssri ygftavdlkp sgedemitmd naeeyvdlmf dfcmhtgiqk qmeafrdgfn
     1921 kvfpmeklss fsheevqmil cgnqspswaa ediinytepk lgytrdspgf lrfvrvlcgm
     1981 ssderkaflq fttgcstlpp gglanlhprl tvvrkvdatd asypsvntcv hylklpeyss
     2041 eeimrerlla atmekgfhln
//
LOCUS       XP_005267567             721 aa            linear   PRI 05-AUG-2025
DEFINITION  low-density lipoprotein receptor-related protein 10 isoform X1
            [Homo sapiens].
ACCESSION   XP_005267567
VERSION     XP_005267567.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267510.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..721
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..721
                     /product="low-density lipoprotein receptor-related protein
                     10 isoform X1"
                     /calculated_mol_wt=76767
     Region          34..134
                     /region_name="CUB"
                     /note="CUB domain; extracellular domain; present in
                     proteins mostly known to be involved in development; not
                     found in prokaryotes, plants and yeast; cd00041"
                     /db_xref="CDD:238001"
     Site            order(39,41,43,70,75,104,130,132,134)
                     /site_type="other"
                     /note="heterodimerization interface [polypeptide binding]"
                     /db_xref="CDD:238001"
     Region          148..182
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(153,161,172..173)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(165,168,172,178..179)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            175..179
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          200..310
                     /region_name="CUB"
                     /note="CUB domain; extracellular domain; present in
                     proteins mostly known to be involved in development; not
                     found in prokaryotes, plants and yeast; cd00041"
                     /db_xref="CDD:238001"
     Site            order(208,210,212,241,246,283,307,309)
                     /site_type="other"
                     /note="heterodimerization interface [polypeptide binding]"
                     /db_xref="CDD:238001"
     Region          <338..361
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(344,347,351,357..358)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            354..358
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          407..441
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(412,420,431..432)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(424,427,431,437..438)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            434..438
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          <581..683
                     /region_name="PRK04654"
                     /note="sec-independent translocase; Provisional"
                     /db_xref="CDD:135173"
     CDS             1..721
                     /gene="LRP10"
                     /gene_synonym="LRP-10; LRP9; MST087; MSTP087"
                     /coded_by="XM_005267510.2:565..2730"
                     /db_xref="GeneID:26020"
                     /db_xref="HGNC:HGNC:14553"
                     /db_xref="MIM:609921"
ORIGIN      
        1 mllatlllll lggalahpdr iifpnhaced ppavllevqg tlqrplvrds rtspanctwl
       61 ilgskeqtvt irfqklhlac gserltlrsp lqplislcea ppsplqlpgg nvtitysyag
      121 arapmgqgfl lsysqaplhg asadwlmclq eefqclnhrc vsavqrcdgv dacgdgsdea
      181 gcssdpfpgl tprpvpslpc nvtledfygv fsspgythla svshpqschw lldphdgrrl
      241 avrftaldlg fgdavhvydg pgppessrll rslthfsngk avtvetlsgq avvsyhtvaw
      301 sngrgfnaty hvrgyclpwd rpcglgsglg ageglgercy seaqrcdgsw dcadgtdeed
      361 cpgcppghfp cgaagtsgat acylpadrcn yqtfcadgad errcrhcqpg nfrcrdekcv
      421 yetwvcdgqp dcadgsdewd csyvlprkvi taavigslvc glllvialgc tcklyairtq
      481 eysifaplsr meaeivqqqa ppsygqliaq gaippvedfp tenpndnsvl gnlrsllqil
      541 rqdmtpgggp garrrqrgrl mrrlvrrlrr wgllprtntp arasearsqv tpsaapleal
      601 dggtgpareg gavggqdgeq applpikapl psastspapt tvpeapgplp slplepslls
      661 gvvqalrgrl lpslgppgpt rsppgphtav lalededdvl lvplaepgvw vaeaedepll
      721 t
//
LOCUS       XP_005267573            1804 aa            linear   PRI 05-AUG-2025
DEFINITION  signal-induced proliferation-associated 1-like protein 1 isoform X1
            [Homo sapiens].
ACCESSION   XP_005267573
VERSION     XP_005267573.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267516.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1804
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1804
                     /product="signal-induced proliferation-associated 1-like
                     protein 1 isoform X1"
                     /calculated_mol_wt=199898
     Region          629..809
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     Region          953..1025
                     /region_name="PDZ_SIPA1-like"
                     /note="PDZ domain of signal-induced
                     proliferation-associated protein 1 (SIPA1), and related
                     domains; cd06745"
                     /db_xref="CDD:467227"
     Site            order(963..969,975,978,1007,1011,1014..1015)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467227"
     Region          1504..1749
                     /region_name="SPAR_C"
                     /note="C-terminal domain of SPAR protein; pfam11881"
                     /db_xref="CDD:463383"
     Region          1737..1792
                     /region_name="ZapB"
                     /note="Cell division protein ZapB; pfam06005"
                     /db_xref="CDD:428718"
     CDS             1..1804
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /coded_by="XM_005267516.5:934..6348"
                     /db_xref="GeneID:26037"
                     /db_xref="HGNC:HGNC:20284"
                     /db_xref="MIM:617504"
ORIGIN      
        1 mtslkrsqte rplatdrasv vgtdgtpkvh tddfymrrfr sqngslgssv mapvgpprse
       61 gshhitstpg vpkmgvrari adwpprkeni kessrssqei etsscldsls sksspvsqgs
      121 svslnsndsa mlksiqntlk nktrpsenmd srflmpeayp ssprkalrri rqrsnsditi
      181 seldvdsfde cisptyktgp slhreygsts sidkqgtsge sffdllkgyk ddksdrgptp
      241 tklsdflitg ggkgsgfsld vidgpisqre nlrlfkerek plkrrskset gdssifrklr
      301 nakgeelgks sdlednrsed svrpwtcpkc fahydvqsil fdlneaimnr hnvikrrntt
      361 tgasaaavas lvsgplshsa sfsspmgste dlnskgslsm dqgddksnel vmscpyfrne
      421 iggegerkis lsksnsgsfs gcesasfest lsshctnagv avlevpkenl vlhldrvkry
      481 ivehvdlgay yyrkffyqke hwnyfgaden lgpvavsirr ekpdemkeng spynyriifr
      541 tselmtlrgs vledaipsta khstarglpl kevlehvvpe lnvqclrlaf ntpkvteqlm
      601 kldeqglnyq qkvgimycka gqsteeemyn nesagpafee flqllgervr lkgfekyraq
      661 ldtktdstgt hslyttykdy eimfhvstml pytpnnkqql lrkrhigndi vtivfqepga
      721 qpfspknirs hfqhvfvivr vhnpcsdsvc ysvavtrsrd vpsfgppipk gvtfpksnvf
      781 rdfllakvin aenaahksek framatrtrq eylkdlaekn vtntpidpsg kfpfislask
      841 kkekskpypg aelssmgaiv wavraedynk ameldcllgi snefivlieq etksvvfncs
      901 crdvigwtst dtslkifyer gecvsvgsfi nieeikeivk rlqfvskgce svemtlrrng
      961 lgqlgfhvny egivadvepy gyawqaglrq gsrlveickv avatlsheqm idllrtsvtv
     1021 kvviipphdd ctprrscset yrmpvmeykm negvsyefkf pfrnnnkwqr naskgphspq
     1081 vpsqvqspmt srlnagkgdg kmppperaan iprsissdgr plerrlspgs diyvtvssma
     1141 larsqcrnsp snlssssdtg svggtyrqks mpegfgvsrr spasidrqnt qsdiggsgks
     1201 tpswqrseds iadqmaysyr gpqdfnsfvl eqheyteptc hlpavskvlp afrespsgrl
     1261 mrqdpvvhls pnkqghsdsh ysshsssntl ssnassahsd ekwydgdrte selnsynylq
     1321 gtsadsgidt tsygpshgst aslgaatssp rsgpgkekva plwhsssevi smadrtlete
     1381 shgldrktes slsldihsks qagstpltre nstfsindaa shtstmssrh saspvvftsa
     1441 rsspkeelhp aapsqlapsf ssssssssgp rsfyprqgat skyligwkkp egtinsvgfm
     1501 dtrkrhqsdg neiahtrlra strdlraspk ptskstieed lkklidlesp tpesqksfkf
     1561 halsspqspf pstptsrral hrtlsdesiy nsqrehffts raslldqalp ndvlfsstyp
     1621 slpkslplrr psytlgmksl hgefsasdss ltdiqetrrq pmpdpglmpl pdtaadldws
     1681 nlvdaakaye vqrasffaas denhrplsaa snsdqledqa laqmkpysss kdssptlask
     1741 vdqlegmlkm lredlkkeke dkahlqaevq hlrednlrlq eesqnasdkl kkftewvfnt
     1801 idms
//
LOCUS       XP_047287165            1804 aa            linear   PRI 05-AUG-2025
DEFINITION  signal-induced proliferation-associated 1-like protein 1 isoform X1
            [Homo sapiens].
ACCESSION   XP_047287165
VERSION     XP_047287165.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431209.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1804
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1804
                     /product="signal-induced proliferation-associated 1-like
                     protein 1 isoform X1"
                     /calculated_mol_wt=199898
     Region          629..809
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     Region          953..1025
                     /region_name="PDZ_SIPA1-like"
                     /note="PDZ domain of signal-induced
                     proliferation-associated protein 1 (SIPA1), and related
                     domains; cd06745"
                     /db_xref="CDD:467227"
     Site            order(963..969,975,978,1007,1011,1014..1015)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467227"
     Region          1504..1749
                     /region_name="SPAR_C"
                     /note="C-terminal domain of SPAR protein; pfam11881"
                     /db_xref="CDD:463383"
     Region          1737..1792
                     /region_name="ZapB"
                     /note="Cell division protein ZapB; pfam06005"
                     /db_xref="CDD:428718"
     CDS             1..1804
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /coded_by="XM_047431209.1:740..6154"
                     /db_xref="GeneID:26037"
                     /db_xref="HGNC:HGNC:20284"
                     /db_xref="MIM:617504"
ORIGIN      
        1 mtslkrsqte rplatdrasv vgtdgtpkvh tddfymrrfr sqngslgssv mapvgpprse
       61 gshhitstpg vpkmgvrari adwpprkeni kessrssqei etsscldsls sksspvsqgs
      121 svslnsndsa mlksiqntlk nktrpsenmd srflmpeayp ssprkalrri rqrsnsditi
      181 seldvdsfde cisptyktgp slhreygsts sidkqgtsge sffdllkgyk ddksdrgptp
      241 tklsdflitg ggkgsgfsld vidgpisqre nlrlfkerek plkrrskset gdssifrklr
      301 nakgeelgks sdlednrsed svrpwtcpkc fahydvqsil fdlneaimnr hnvikrrntt
      361 tgasaaavas lvsgplshsa sfsspmgste dlnskgslsm dqgddksnel vmscpyfrne
      421 iggegerkis lsksnsgsfs gcesasfest lsshctnagv avlevpkenl vlhldrvkry
      481 ivehvdlgay yyrkffyqke hwnyfgaden lgpvavsirr ekpdemkeng spynyriifr
      541 tselmtlrgs vledaipsta khstarglpl kevlehvvpe lnvqclrlaf ntpkvteqlm
      601 kldeqglnyq qkvgimycka gqsteeemyn nesagpafee flqllgervr lkgfekyraq
      661 ldtktdstgt hslyttykdy eimfhvstml pytpnnkqql lrkrhigndi vtivfqepga
      721 qpfspknirs hfqhvfvivr vhnpcsdsvc ysvavtrsrd vpsfgppipk gvtfpksnvf
      781 rdfllakvin aenaahksek framatrtrq eylkdlaekn vtntpidpsg kfpfislask
      841 kkekskpypg aelssmgaiv wavraedynk ameldcllgi snefivlieq etksvvfncs
      901 crdvigwtst dtslkifyer gecvsvgsfi nieeikeivk rlqfvskgce svemtlrrng
      961 lgqlgfhvny egivadvepy gyawqaglrq gsrlveickv avatlsheqm idllrtsvtv
     1021 kvviipphdd ctprrscset yrmpvmeykm negvsyefkf pfrnnnkwqr naskgphspq
     1081 vpsqvqspmt srlnagkgdg kmppperaan iprsissdgr plerrlspgs diyvtvssma
     1141 larsqcrnsp snlssssdtg svggtyrqks mpegfgvsrr spasidrqnt qsdiggsgks
     1201 tpswqrseds iadqmaysyr gpqdfnsfvl eqheyteptc hlpavskvlp afrespsgrl
     1261 mrqdpvvhls pnkqghsdsh ysshsssntl ssnassahsd ekwydgdrte selnsynylq
     1321 gtsadsgidt tsygpshgst aslgaatssp rsgpgkekva plwhsssevi smadrtlete
     1381 shgldrktes slsldihsks qagstpltre nstfsindaa shtstmssrh saspvvftsa
     1441 rsspkeelhp aapsqlapsf ssssssssgp rsfyprqgat skyligwkkp egtinsvgfm
     1501 dtrkrhqsdg neiahtrlra strdlraspk ptskstieed lkklidlesp tpesqksfkf
     1561 halsspqspf pstptsrral hrtlsdesiy nsqrehffts raslldqalp ndvlfsstyp
     1621 slpkslplrr psytlgmksl hgefsasdss ltdiqetrrq pmpdpglmpl pdtaadldws
     1681 nlvdaakaye vqrasffaas denhrplsaa snsdqledqa laqmkpysss kdssptlask
     1741 vdqlegmlkm lredlkkeke dkahlqaevq hlrednlrlq eesqnasdkl kkftewvfnt
     1801 idms
//
LOCUS       XP_047287167            1804 aa            linear   PRI 05-AUG-2025
DEFINITION  signal-induced proliferation-associated 1-like protein 1 isoform X1
            [Homo sapiens].
ACCESSION   XP_047287167
VERSION     XP_047287167.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431211.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1804
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1804
                     /product="signal-induced proliferation-associated 1-like
                     protein 1 isoform X1"
                     /calculated_mol_wt=199898
     Region          629..809
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     Region          953..1025
                     /region_name="PDZ_SIPA1-like"
                     /note="PDZ domain of signal-induced
                     proliferation-associated protein 1 (SIPA1), and related
                     domains; cd06745"
                     /db_xref="CDD:467227"
     Site            order(963..969,975,978,1007,1011,1014..1015)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467227"
     Region          1504..1749
                     /region_name="SPAR_C"
                     /note="C-terminal domain of SPAR protein; pfam11881"
                     /db_xref="CDD:463383"
     Region          1737..1792
                     /region_name="ZapB"
                     /note="Cell division protein ZapB; pfam06005"
                     /db_xref="CDD:428718"
     CDS             1..1804
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /coded_by="XM_047431211.1:2294..7708"
                     /db_xref="GeneID:26037"
                     /db_xref="HGNC:HGNC:20284"
                     /db_xref="MIM:617504"
ORIGIN      
        1 mtslkrsqte rplatdrasv vgtdgtpkvh tddfymrrfr sqngslgssv mapvgpprse
       61 gshhitstpg vpkmgvrari adwpprkeni kessrssqei etsscldsls sksspvsqgs
      121 svslnsndsa mlksiqntlk nktrpsenmd srflmpeayp ssprkalrri rqrsnsditi
      181 seldvdsfde cisptyktgp slhreygsts sidkqgtsge sffdllkgyk ddksdrgptp
      241 tklsdflitg ggkgsgfsld vidgpisqre nlrlfkerek plkrrskset gdssifrklr
      301 nakgeelgks sdlednrsed svrpwtcpkc fahydvqsil fdlneaimnr hnvikrrntt
      361 tgasaaavas lvsgplshsa sfsspmgste dlnskgslsm dqgddksnel vmscpyfrne
      421 iggegerkis lsksnsgsfs gcesasfest lsshctnagv avlevpkenl vlhldrvkry
      481 ivehvdlgay yyrkffyqke hwnyfgaden lgpvavsirr ekpdemkeng spynyriifr
      541 tselmtlrgs vledaipsta khstarglpl kevlehvvpe lnvqclrlaf ntpkvteqlm
      601 kldeqglnyq qkvgimycka gqsteeemyn nesagpafee flqllgervr lkgfekyraq
      661 ldtktdstgt hslyttykdy eimfhvstml pytpnnkqql lrkrhigndi vtivfqepga
      721 qpfspknirs hfqhvfvivr vhnpcsdsvc ysvavtrsrd vpsfgppipk gvtfpksnvf
      781 rdfllakvin aenaahksek framatrtrq eylkdlaekn vtntpidpsg kfpfislask
      841 kkekskpypg aelssmgaiv wavraedynk ameldcllgi snefivlieq etksvvfncs
      901 crdvigwtst dtslkifyer gecvsvgsfi nieeikeivk rlqfvskgce svemtlrrng
      961 lgqlgfhvny egivadvepy gyawqaglrq gsrlveickv avatlsheqm idllrtsvtv
     1021 kvviipphdd ctprrscset yrmpvmeykm negvsyefkf pfrnnnkwqr naskgphspq
     1081 vpsqvqspmt srlnagkgdg kmppperaan iprsissdgr plerrlspgs diyvtvssma
     1141 larsqcrnsp snlssssdtg svggtyrqks mpegfgvsrr spasidrqnt qsdiggsgks
     1201 tpswqrseds iadqmaysyr gpqdfnsfvl eqheyteptc hlpavskvlp afrespsgrl
     1261 mrqdpvvhls pnkqghsdsh ysshsssntl ssnassahsd ekwydgdrte selnsynylq
     1321 gtsadsgidt tsygpshgst aslgaatssp rsgpgkekva plwhsssevi smadrtlete
     1381 shgldrktes slsldihsks qagstpltre nstfsindaa shtstmssrh saspvvftsa
     1441 rsspkeelhp aapsqlapsf ssssssssgp rsfyprqgat skyligwkkp egtinsvgfm
     1501 dtrkrhqsdg neiahtrlra strdlraspk ptskstieed lkklidlesp tpesqksfkf
     1561 halsspqspf pstptsrral hrtlsdesiy nsqrehffts raslldqalp ndvlfsstyp
     1621 slpkslplrr psytlgmksl hgefsasdss ltdiqetrrq pmpdpglmpl pdtaadldws
     1681 nlvdaakaye vqrasffaas denhrplsaa snsdqledqa laqmkpysss kdssptlask
     1741 vdqlegmlkm lredlkkeke dkahlqaevq hlrednlrlq eesqnasdkl kkftewvfnt
     1801 idms
//
LOCUS       XP_047287168            1804 aa            linear   PRI 05-AUG-2025
DEFINITION  signal-induced proliferation-associated 1-like protein 1 isoform X1
            [Homo sapiens].
ACCESSION   XP_047287168
VERSION     XP_047287168.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431212.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1804
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1804
                     /product="signal-induced proliferation-associated 1-like
                     protein 1 isoform X1"
                     /calculated_mol_wt=199898
     Region          629..809
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     Region          953..1025
                     /region_name="PDZ_SIPA1-like"
                     /note="PDZ domain of signal-induced
                     proliferation-associated protein 1 (SIPA1), and related
                     domains; cd06745"
                     /db_xref="CDD:467227"
     Site            order(963..969,975,978,1007,1011,1014..1015)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467227"
     Region          1504..1749
                     /region_name="SPAR_C"
                     /note="C-terminal domain of SPAR protein; pfam11881"
                     /db_xref="CDD:463383"
     Region          1737..1792
                     /region_name="ZapB"
                     /note="Cell division protein ZapB; pfam06005"
                     /db_xref="CDD:428718"
     CDS             1..1804
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /coded_by="XM_047431212.1:2309..7723"
                     /db_xref="GeneID:26037"
                     /db_xref="HGNC:HGNC:20284"
                     /db_xref="MIM:617504"
ORIGIN      
        1 mtslkrsqte rplatdrasv vgtdgtpkvh tddfymrrfr sqngslgssv mapvgpprse
       61 gshhitstpg vpkmgvrari adwpprkeni kessrssqei etsscldsls sksspvsqgs
      121 svslnsndsa mlksiqntlk nktrpsenmd srflmpeayp ssprkalrri rqrsnsditi
      181 seldvdsfde cisptyktgp slhreygsts sidkqgtsge sffdllkgyk ddksdrgptp
      241 tklsdflitg ggkgsgfsld vidgpisqre nlrlfkerek plkrrskset gdssifrklr
      301 nakgeelgks sdlednrsed svrpwtcpkc fahydvqsil fdlneaimnr hnvikrrntt
      361 tgasaaavas lvsgplshsa sfsspmgste dlnskgslsm dqgddksnel vmscpyfrne
      421 iggegerkis lsksnsgsfs gcesasfest lsshctnagv avlevpkenl vlhldrvkry
      481 ivehvdlgay yyrkffyqke hwnyfgaden lgpvavsirr ekpdemkeng spynyriifr
      541 tselmtlrgs vledaipsta khstarglpl kevlehvvpe lnvqclrlaf ntpkvteqlm
      601 kldeqglnyq qkvgimycka gqsteeemyn nesagpafee flqllgervr lkgfekyraq
      661 ldtktdstgt hslyttykdy eimfhvstml pytpnnkqql lrkrhigndi vtivfqepga
      721 qpfspknirs hfqhvfvivr vhnpcsdsvc ysvavtrsrd vpsfgppipk gvtfpksnvf
      781 rdfllakvin aenaahksek framatrtrq eylkdlaekn vtntpidpsg kfpfislask
      841 kkekskpypg aelssmgaiv wavraedynk ameldcllgi snefivlieq etksvvfncs
      901 crdvigwtst dtslkifyer gecvsvgsfi nieeikeivk rlqfvskgce svemtlrrng
      961 lgqlgfhvny egivadvepy gyawqaglrq gsrlveickv avatlsheqm idllrtsvtv
     1021 kvviipphdd ctprrscset yrmpvmeykm negvsyefkf pfrnnnkwqr naskgphspq
     1081 vpsqvqspmt srlnagkgdg kmppperaan iprsissdgr plerrlspgs diyvtvssma
     1141 larsqcrnsp snlssssdtg svggtyrqks mpegfgvsrr spasidrqnt qsdiggsgks
     1201 tpswqrseds iadqmaysyr gpqdfnsfvl eqheyteptc hlpavskvlp afrespsgrl
     1261 mrqdpvvhls pnkqghsdsh ysshsssntl ssnassahsd ekwydgdrte selnsynylq
     1321 gtsadsgidt tsygpshgst aslgaatssp rsgpgkekva plwhsssevi smadrtlete
     1381 shgldrktes slsldihsks qagstpltre nstfsindaa shtstmssrh saspvvftsa
     1441 rsspkeelhp aapsqlapsf ssssssssgp rsfyprqgat skyligwkkp egtinsvgfm
     1501 dtrkrhqsdg neiahtrlra strdlraspk ptskstieed lkklidlesp tpesqksfkf
     1561 halsspqspf pstptsrral hrtlsdesiy nsqrehffts raslldqalp ndvlfsstyp
     1621 slpkslplrr psytlgmksl hgefsasdss ltdiqetrrq pmpdpglmpl pdtaadldws
     1681 nlvdaakaye vqrasffaas denhrplsaa snsdqledqa laqmkpysss kdssptlask
     1741 vdqlegmlkm lredlkkeke dkahlqaevq hlrednlrlq eesqnasdkl kkftewvfnt
     1801 idms
//
LOCUS       XP_047287169            1804 aa            linear   PRI 05-AUG-2025
DEFINITION  signal-induced proliferation-associated 1-like protein 1 isoform X1
            [Homo sapiens].
ACCESSION   XP_047287169
VERSION     XP_047287169.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431213.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1804
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1804
                     /product="signal-induced proliferation-associated 1-like
                     protein 1 isoform X1"
                     /calculated_mol_wt=199898
     Region          629..809
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     Region          953..1025
                     /region_name="PDZ_SIPA1-like"
                     /note="PDZ domain of signal-induced
                     proliferation-associated protein 1 (SIPA1), and related
                     domains; cd06745"
                     /db_xref="CDD:467227"
     Site            order(963..969,975,978,1007,1011,1014..1015)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467227"
     Region          1504..1749
                     /region_name="SPAR_C"
                     /note="C-terminal domain of SPAR protein; pfam11881"
                     /db_xref="CDD:463383"
     Region          1737..1792
                     /region_name="ZapB"
                     /note="Cell division protein ZapB; pfam06005"
                     /db_xref="CDD:428718"
     CDS             1..1804
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /coded_by="XM_047431213.1:2381..7795"
                     /db_xref="GeneID:26037"
                     /db_xref="HGNC:HGNC:20284"
                     /db_xref="MIM:617504"
ORIGIN      
        1 mtslkrsqte rplatdrasv vgtdgtpkvh tddfymrrfr sqngslgssv mapvgpprse
       61 gshhitstpg vpkmgvrari adwpprkeni kessrssqei etsscldsls sksspvsqgs
      121 svslnsndsa mlksiqntlk nktrpsenmd srflmpeayp ssprkalrri rqrsnsditi
      181 seldvdsfde cisptyktgp slhreygsts sidkqgtsge sffdllkgyk ddksdrgptp
      241 tklsdflitg ggkgsgfsld vidgpisqre nlrlfkerek plkrrskset gdssifrklr
      301 nakgeelgks sdlednrsed svrpwtcpkc fahydvqsil fdlneaimnr hnvikrrntt
      361 tgasaaavas lvsgplshsa sfsspmgste dlnskgslsm dqgddksnel vmscpyfrne
      421 iggegerkis lsksnsgsfs gcesasfest lsshctnagv avlevpkenl vlhldrvkry
      481 ivehvdlgay yyrkffyqke hwnyfgaden lgpvavsirr ekpdemkeng spynyriifr
      541 tselmtlrgs vledaipsta khstarglpl kevlehvvpe lnvqclrlaf ntpkvteqlm
      601 kldeqglnyq qkvgimycka gqsteeemyn nesagpafee flqllgervr lkgfekyraq
      661 ldtktdstgt hslyttykdy eimfhvstml pytpnnkqql lrkrhigndi vtivfqepga
      721 qpfspknirs hfqhvfvivr vhnpcsdsvc ysvavtrsrd vpsfgppipk gvtfpksnvf
      781 rdfllakvin aenaahksek framatrtrq eylkdlaekn vtntpidpsg kfpfislask
      841 kkekskpypg aelssmgaiv wavraedynk ameldcllgi snefivlieq etksvvfncs
      901 crdvigwtst dtslkifyer gecvsvgsfi nieeikeivk rlqfvskgce svemtlrrng
      961 lgqlgfhvny egivadvepy gyawqaglrq gsrlveickv avatlsheqm idllrtsvtv
     1021 kvviipphdd ctprrscset yrmpvmeykm negvsyefkf pfrnnnkwqr naskgphspq
     1081 vpsqvqspmt srlnagkgdg kmppperaan iprsissdgr plerrlspgs diyvtvssma
     1141 larsqcrnsp snlssssdtg svggtyrqks mpegfgvsrr spasidrqnt qsdiggsgks
     1201 tpswqrseds iadqmaysyr gpqdfnsfvl eqheyteptc hlpavskvlp afrespsgrl
     1261 mrqdpvvhls pnkqghsdsh ysshsssntl ssnassahsd ekwydgdrte selnsynylq
     1321 gtsadsgidt tsygpshgst aslgaatssp rsgpgkekva plwhsssevi smadrtlete
     1381 shgldrktes slsldihsks qagstpltre nstfsindaa shtstmssrh saspvvftsa
     1441 rsspkeelhp aapsqlapsf ssssssssgp rsfyprqgat skyligwkkp egtinsvgfm
     1501 dtrkrhqsdg neiahtrlra strdlraspk ptskstieed lkklidlesp tpesqksfkf
     1561 halsspqspf pstptsrral hrtlsdesiy nsqrehffts raslldqalp ndvlfsstyp
     1621 slpkslplrr psytlgmksl hgefsasdss ltdiqetrrq pmpdpglmpl pdtaadldws
     1681 nlvdaakaye vqrasffaas denhrplsaa snsdqledqa laqmkpysss kdssptlask
     1741 vdqlegmlkm lredlkkeke dkahlqaevq hlrednlrlq eesqnasdkl kkftewvfnt
     1801 idms
//
LOCUS       XP_047287170            1804 aa            linear   PRI 05-AUG-2025
DEFINITION  signal-induced proliferation-associated 1-like protein 1 isoform X1
            [Homo sapiens].
ACCESSION   XP_047287170
VERSION     XP_047287170.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431214.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1804
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1804
                     /product="signal-induced proliferation-associated 1-like
                     protein 1 isoform X1"
                     /calculated_mol_wt=199898
     Region          629..809
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     Region          953..1025
                     /region_name="PDZ_SIPA1-like"
                     /note="PDZ domain of signal-induced
                     proliferation-associated protein 1 (SIPA1), and related
                     domains; cd06745"
                     /db_xref="CDD:467227"
     Site            order(963..969,975,978,1007,1011,1014..1015)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467227"
     Region          1504..1749
                     /region_name="SPAR_C"
                     /note="C-terminal domain of SPAR protein; pfam11881"
                     /db_xref="CDD:463383"
     Region          1737..1792
                     /region_name="ZapB"
                     /note="Cell division protein ZapB; pfam06005"
                     /db_xref="CDD:428718"
     CDS             1..1804
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /coded_by="XM_047431214.1:2507..7921"
                     /db_xref="GeneID:26037"
                     /db_xref="HGNC:HGNC:20284"
                     /db_xref="MIM:617504"
ORIGIN      
        1 mtslkrsqte rplatdrasv vgtdgtpkvh tddfymrrfr sqngslgssv mapvgpprse
       61 gshhitstpg vpkmgvrari adwpprkeni kessrssqei etsscldsls sksspvsqgs
      121 svslnsndsa mlksiqntlk nktrpsenmd srflmpeayp ssprkalrri rqrsnsditi
      181 seldvdsfde cisptyktgp slhreygsts sidkqgtsge sffdllkgyk ddksdrgptp
      241 tklsdflitg ggkgsgfsld vidgpisqre nlrlfkerek plkrrskset gdssifrklr
      301 nakgeelgks sdlednrsed svrpwtcpkc fahydvqsil fdlneaimnr hnvikrrntt
      361 tgasaaavas lvsgplshsa sfsspmgste dlnskgslsm dqgddksnel vmscpyfrne
      421 iggegerkis lsksnsgsfs gcesasfest lsshctnagv avlevpkenl vlhldrvkry
      481 ivehvdlgay yyrkffyqke hwnyfgaden lgpvavsirr ekpdemkeng spynyriifr
      541 tselmtlrgs vledaipsta khstarglpl kevlehvvpe lnvqclrlaf ntpkvteqlm
      601 kldeqglnyq qkvgimycka gqsteeemyn nesagpafee flqllgervr lkgfekyraq
      661 ldtktdstgt hslyttykdy eimfhvstml pytpnnkqql lrkrhigndi vtivfqepga
      721 qpfspknirs hfqhvfvivr vhnpcsdsvc ysvavtrsrd vpsfgppipk gvtfpksnvf
      781 rdfllakvin aenaahksek framatrtrq eylkdlaekn vtntpidpsg kfpfislask
      841 kkekskpypg aelssmgaiv wavraedynk ameldcllgi snefivlieq etksvvfncs
      901 crdvigwtst dtslkifyer gecvsvgsfi nieeikeivk rlqfvskgce svemtlrrng
      961 lgqlgfhvny egivadvepy gyawqaglrq gsrlveickv avatlsheqm idllrtsvtv
     1021 kvviipphdd ctprrscset yrmpvmeykm negvsyefkf pfrnnnkwqr naskgphspq
     1081 vpsqvqspmt srlnagkgdg kmppperaan iprsissdgr plerrlspgs diyvtvssma
     1141 larsqcrnsp snlssssdtg svggtyrqks mpegfgvsrr spasidrqnt qsdiggsgks
     1201 tpswqrseds iadqmaysyr gpqdfnsfvl eqheyteptc hlpavskvlp afrespsgrl
     1261 mrqdpvvhls pnkqghsdsh ysshsssntl ssnassahsd ekwydgdrte selnsynylq
     1321 gtsadsgidt tsygpshgst aslgaatssp rsgpgkekva plwhsssevi smadrtlete
     1381 shgldrktes slsldihsks qagstpltre nstfsindaa shtstmssrh saspvvftsa
     1441 rsspkeelhp aapsqlapsf ssssssssgp rsfyprqgat skyligwkkp egtinsvgfm
     1501 dtrkrhqsdg neiahtrlra strdlraspk ptskstieed lkklidlesp tpesqksfkf
     1561 halsspqspf pstptsrral hrtlsdesiy nsqrehffts raslldqalp ndvlfsstyp
     1621 slpkslplrr psytlgmksl hgefsasdss ltdiqetrrq pmpdpglmpl pdtaadldws
     1681 nlvdaakaye vqrasffaas denhrplsaa snsdqledqa laqmkpysss kdssptlask
     1741 vdqlegmlkm lredlkkeke dkahlqaevq hlrednlrlq eesqnasdkl kkftewvfnt
     1801 idms
//
LOCUS       XP_047287171            1804 aa            linear   PRI 05-AUG-2025
DEFINITION  signal-induced proliferation-associated 1-like protein 1 isoform X1
            [Homo sapiens].
ACCESSION   XP_047287171
VERSION     XP_047287171.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431215.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1804
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1804
                     /product="signal-induced proliferation-associated 1-like
                     protein 1 isoform X1"
                     /calculated_mol_wt=199898
     Region          629..809
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     Region          953..1025
                     /region_name="PDZ_SIPA1-like"
                     /note="PDZ domain of signal-induced
                     proliferation-associated protein 1 (SIPA1), and related
                     domains; cd06745"
                     /db_xref="CDD:467227"
     Site            order(963..969,975,978,1007,1011,1014..1015)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467227"
     Region          1504..1749
                     /region_name="SPAR_C"
                     /note="C-terminal domain of SPAR protein; pfam11881"
                     /db_xref="CDD:463383"
     Region          1737..1792
                     /region_name="ZapB"
                     /note="Cell division protein ZapB; pfam06005"
                     /db_xref="CDD:428718"
     CDS             1..1804
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /coded_by="XM_047431215.1:2438..7852"
                     /db_xref="GeneID:26037"
                     /db_xref="HGNC:HGNC:20284"
                     /db_xref="MIM:617504"
ORIGIN      
        1 mtslkrsqte rplatdrasv vgtdgtpkvh tddfymrrfr sqngslgssv mapvgpprse
       61 gshhitstpg vpkmgvrari adwpprkeni kessrssqei etsscldsls sksspvsqgs
      121 svslnsndsa mlksiqntlk nktrpsenmd srflmpeayp ssprkalrri rqrsnsditi
      181 seldvdsfde cisptyktgp slhreygsts sidkqgtsge sffdllkgyk ddksdrgptp
      241 tklsdflitg ggkgsgfsld vidgpisqre nlrlfkerek plkrrskset gdssifrklr
      301 nakgeelgks sdlednrsed svrpwtcpkc fahydvqsil fdlneaimnr hnvikrrntt
      361 tgasaaavas lvsgplshsa sfsspmgste dlnskgslsm dqgddksnel vmscpyfrne
      421 iggegerkis lsksnsgsfs gcesasfest lsshctnagv avlevpkenl vlhldrvkry
      481 ivehvdlgay yyrkffyqke hwnyfgaden lgpvavsirr ekpdemkeng spynyriifr
      541 tselmtlrgs vledaipsta khstarglpl kevlehvvpe lnvqclrlaf ntpkvteqlm
      601 kldeqglnyq qkvgimycka gqsteeemyn nesagpafee flqllgervr lkgfekyraq
      661 ldtktdstgt hslyttykdy eimfhvstml pytpnnkqql lrkrhigndi vtivfqepga
      721 qpfspknirs hfqhvfvivr vhnpcsdsvc ysvavtrsrd vpsfgppipk gvtfpksnvf
      781 rdfllakvin aenaahksek framatrtrq eylkdlaekn vtntpidpsg kfpfislask
      841 kkekskpypg aelssmgaiv wavraedynk ameldcllgi snefivlieq etksvvfncs
      901 crdvigwtst dtslkifyer gecvsvgsfi nieeikeivk rlqfvskgce svemtlrrng
      961 lgqlgfhvny egivadvepy gyawqaglrq gsrlveickv avatlsheqm idllrtsvtv
     1021 kvviipphdd ctprrscset yrmpvmeykm negvsyefkf pfrnnnkwqr naskgphspq
     1081 vpsqvqspmt srlnagkgdg kmppperaan iprsissdgr plerrlspgs diyvtvssma
     1141 larsqcrnsp snlssssdtg svggtyrqks mpegfgvsrr spasidrqnt qsdiggsgks
     1201 tpswqrseds iadqmaysyr gpqdfnsfvl eqheyteptc hlpavskvlp afrespsgrl
     1261 mrqdpvvhls pnkqghsdsh ysshsssntl ssnassahsd ekwydgdrte selnsynylq
     1321 gtsadsgidt tsygpshgst aslgaatssp rsgpgkekva plwhsssevi smadrtlete
     1381 shgldrktes slsldihsks qagstpltre nstfsindaa shtstmssrh saspvvftsa
     1441 rsspkeelhp aapsqlapsf ssssssssgp rsfyprqgat skyligwkkp egtinsvgfm
     1501 dtrkrhqsdg neiahtrlra strdlraspk ptskstieed lkklidlesp tpesqksfkf
     1561 halsspqspf pstptsrral hrtlsdesiy nsqrehffts raslldqalp ndvlfsstyp
     1621 slpkslplrr psytlgmksl hgefsasdss ltdiqetrrq pmpdpglmpl pdtaadldws
     1681 nlvdaakaye vqrasffaas denhrplsaa snsdqledqa laqmkpysss kdssptlask
     1741 vdqlegmlkm lredlkkeke dkahlqaevq hlrednlrlq eesqnasdkl kkftewvfnt
     1801 idms
//
LOCUS       XP_047287172            1804 aa            linear   PRI 05-AUG-2025
DEFINITION  signal-induced proliferation-associated 1-like protein 1 isoform X1
            [Homo sapiens].
ACCESSION   XP_047287172
VERSION     XP_047287172.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431216.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1804
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1804
                     /product="signal-induced proliferation-associated 1-like
                     protein 1 isoform X1"
                     /calculated_mol_wt=199898
     Region          629..809
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     Region          953..1025
                     /region_name="PDZ_SIPA1-like"
                     /note="PDZ domain of signal-induced
                     proliferation-associated protein 1 (SIPA1), and related
                     domains; cd06745"
                     /db_xref="CDD:467227"
     Site            order(963..969,975,978,1007,1011,1014..1015)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467227"
     Region          1504..1749
                     /region_name="SPAR_C"
                     /note="C-terminal domain of SPAR protein; pfam11881"
                     /db_xref="CDD:463383"
     Region          1737..1792
                     /region_name="ZapB"
                     /note="Cell division protein ZapB; pfam06005"
                     /db_xref="CDD:428718"
     CDS             1..1804
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /coded_by="XM_047431216.1:1608..7022"
                     /db_xref="GeneID:26037"
                     /db_xref="HGNC:HGNC:20284"
                     /db_xref="MIM:617504"
ORIGIN      
        1 mtslkrsqte rplatdrasv vgtdgtpkvh tddfymrrfr sqngslgssv mapvgpprse
       61 gshhitstpg vpkmgvrari adwpprkeni kessrssqei etsscldsls sksspvsqgs
      121 svslnsndsa mlksiqntlk nktrpsenmd srflmpeayp ssprkalrri rqrsnsditi
      181 seldvdsfde cisptyktgp slhreygsts sidkqgtsge sffdllkgyk ddksdrgptp
      241 tklsdflitg ggkgsgfsld vidgpisqre nlrlfkerek plkrrskset gdssifrklr
      301 nakgeelgks sdlednrsed svrpwtcpkc fahydvqsil fdlneaimnr hnvikrrntt
      361 tgasaaavas lvsgplshsa sfsspmgste dlnskgslsm dqgddksnel vmscpyfrne
      421 iggegerkis lsksnsgsfs gcesasfest lsshctnagv avlevpkenl vlhldrvkry
      481 ivehvdlgay yyrkffyqke hwnyfgaden lgpvavsirr ekpdemkeng spynyriifr
      541 tselmtlrgs vledaipsta khstarglpl kevlehvvpe lnvqclrlaf ntpkvteqlm
      601 kldeqglnyq qkvgimycka gqsteeemyn nesagpafee flqllgervr lkgfekyraq
      661 ldtktdstgt hslyttykdy eimfhvstml pytpnnkqql lrkrhigndi vtivfqepga
      721 qpfspknirs hfqhvfvivr vhnpcsdsvc ysvavtrsrd vpsfgppipk gvtfpksnvf
      781 rdfllakvin aenaahksek framatrtrq eylkdlaekn vtntpidpsg kfpfislask
      841 kkekskpypg aelssmgaiv wavraedynk ameldcllgi snefivlieq etksvvfncs
      901 crdvigwtst dtslkifyer gecvsvgsfi nieeikeivk rlqfvskgce svemtlrrng
      961 lgqlgfhvny egivadvepy gyawqaglrq gsrlveickv avatlsheqm idllrtsvtv
     1021 kvviipphdd ctprrscset yrmpvmeykm negvsyefkf pfrnnnkwqr naskgphspq
     1081 vpsqvqspmt srlnagkgdg kmppperaan iprsissdgr plerrlspgs diyvtvssma
     1141 larsqcrnsp snlssssdtg svggtyrqks mpegfgvsrr spasidrqnt qsdiggsgks
     1201 tpswqrseds iadqmaysyr gpqdfnsfvl eqheyteptc hlpavskvlp afrespsgrl
     1261 mrqdpvvhls pnkqghsdsh ysshsssntl ssnassahsd ekwydgdrte selnsynylq
     1321 gtsadsgidt tsygpshgst aslgaatssp rsgpgkekva plwhsssevi smadrtlete
     1381 shgldrktes slsldihsks qagstpltre nstfsindaa shtstmssrh saspvvftsa
     1441 rsspkeelhp aapsqlapsf ssssssssgp rsfyprqgat skyligwkkp egtinsvgfm
     1501 dtrkrhqsdg neiahtrlra strdlraspk ptskstieed lkklidlesp tpesqksfkf
     1561 halsspqspf pstptsrral hrtlsdesiy nsqrehffts raslldqalp ndvlfsstyp
     1621 slpkslplrr psytlgmksl hgefsasdss ltdiqetrrq pmpdpglmpl pdtaadldws
     1681 nlvdaakaye vqrasffaas denhrplsaa snsdqledqa laqmkpysss kdssptlask
     1741 vdqlegmlkm lredlkkeke dkahlqaevq hlrednlrlq eesqnasdkl kkftewvfnt
     1801 idms
//
LOCUS       XP_047287173            1804 aa            linear   PRI 05-AUG-2025
DEFINITION  signal-induced proliferation-associated 1-like protein 1 isoform X1
            [Homo sapiens].
ACCESSION   XP_047287173
VERSION     XP_047287173.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431217.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1804
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1804
                     /product="signal-induced proliferation-associated 1-like
                     protein 1 isoform X1"
                     /calculated_mol_wt=199898
     Region          629..809
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     Region          953..1025
                     /region_name="PDZ_SIPA1-like"
                     /note="PDZ domain of signal-induced
                     proliferation-associated protein 1 (SIPA1), and related
                     domains; cd06745"
                     /db_xref="CDD:467227"
     Site            order(963..969,975,978,1007,1011,1014..1015)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467227"
     Region          1504..1749
                     /region_name="SPAR_C"
                     /note="C-terminal domain of SPAR protein; pfam11881"
                     /db_xref="CDD:463383"
     Region          1737..1792
                     /region_name="ZapB"
                     /note="Cell division protein ZapB; pfam06005"
                     /db_xref="CDD:428718"
     CDS             1..1804
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /coded_by="XM_047431217.1:1483..6897"
                     /db_xref="GeneID:26037"
                     /db_xref="HGNC:HGNC:20284"
                     /db_xref="MIM:617504"
ORIGIN      
        1 mtslkrsqte rplatdrasv vgtdgtpkvh tddfymrrfr sqngslgssv mapvgpprse
       61 gshhitstpg vpkmgvrari adwpprkeni kessrssqei etsscldsls sksspvsqgs
      121 svslnsndsa mlksiqntlk nktrpsenmd srflmpeayp ssprkalrri rqrsnsditi
      181 seldvdsfde cisptyktgp slhreygsts sidkqgtsge sffdllkgyk ddksdrgptp
      241 tklsdflitg ggkgsgfsld vidgpisqre nlrlfkerek plkrrskset gdssifrklr
      301 nakgeelgks sdlednrsed svrpwtcpkc fahydvqsil fdlneaimnr hnvikrrntt
      361 tgasaaavas lvsgplshsa sfsspmgste dlnskgslsm dqgddksnel vmscpyfrne
      421 iggegerkis lsksnsgsfs gcesasfest lsshctnagv avlevpkenl vlhldrvkry
      481 ivehvdlgay yyrkffyqke hwnyfgaden lgpvavsirr ekpdemkeng spynyriifr
      541 tselmtlrgs vledaipsta khstarglpl kevlehvvpe lnvqclrlaf ntpkvteqlm
      601 kldeqglnyq qkvgimycka gqsteeemyn nesagpafee flqllgervr lkgfekyraq
      661 ldtktdstgt hslyttykdy eimfhvstml pytpnnkqql lrkrhigndi vtivfqepga
      721 qpfspknirs hfqhvfvivr vhnpcsdsvc ysvavtrsrd vpsfgppipk gvtfpksnvf
      781 rdfllakvin aenaahksek framatrtrq eylkdlaekn vtntpidpsg kfpfislask
      841 kkekskpypg aelssmgaiv wavraedynk ameldcllgi snefivlieq etksvvfncs
      901 crdvigwtst dtslkifyer gecvsvgsfi nieeikeivk rlqfvskgce svemtlrrng
      961 lgqlgfhvny egivadvepy gyawqaglrq gsrlveickv avatlsheqm idllrtsvtv
     1021 kvviipphdd ctprrscset yrmpvmeykm negvsyefkf pfrnnnkwqr naskgphspq
     1081 vpsqvqspmt srlnagkgdg kmppperaan iprsissdgr plerrlspgs diyvtvssma
     1141 larsqcrnsp snlssssdtg svggtyrqks mpegfgvsrr spasidrqnt qsdiggsgks
     1201 tpswqrseds iadqmaysyr gpqdfnsfvl eqheyteptc hlpavskvlp afrespsgrl
     1261 mrqdpvvhls pnkqghsdsh ysshsssntl ssnassahsd ekwydgdrte selnsynylq
     1321 gtsadsgidt tsygpshgst aslgaatssp rsgpgkekva plwhsssevi smadrtlete
     1381 shgldrktes slsldihsks qagstpltre nstfsindaa shtstmssrh saspvvftsa
     1441 rsspkeelhp aapsqlapsf ssssssssgp rsfyprqgat skyligwkkp egtinsvgfm
     1501 dtrkrhqsdg neiahtrlra strdlraspk ptskstieed lkklidlesp tpesqksfkf
     1561 halsspqspf pstptsrral hrtlsdesiy nsqrehffts raslldqalp ndvlfsstyp
     1621 slpkslplrr psytlgmksl hgefsasdss ltdiqetrrq pmpdpglmpl pdtaadldws
     1681 nlvdaakaye vqrasffaas denhrplsaa snsdqledqa laqmkpysss kdssptlask
     1741 vdqlegmlkm lredlkkeke dkahlqaevq hlrednlrlq eesqnasdkl kkftewvfnt
     1801 idms
//
LOCUS       XP_047287174            1804 aa            linear   PRI 05-AUG-2025
DEFINITION  signal-induced proliferation-associated 1-like protein 1 isoform X1
            [Homo sapiens].
ACCESSION   XP_047287174
VERSION     XP_047287174.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431218.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1804
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1804
                     /product="signal-induced proliferation-associated 1-like
                     protein 1 isoform X1"
                     /calculated_mol_wt=199898
     Region          629..809
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     Region          953..1025
                     /region_name="PDZ_SIPA1-like"
                     /note="PDZ domain of signal-induced
                     proliferation-associated protein 1 (SIPA1), and related
                     domains; cd06745"
                     /db_xref="CDD:467227"
     Site            order(963..969,975,978,1007,1011,1014..1015)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467227"
     Region          1504..1749
                     /region_name="SPAR_C"
                     /note="C-terminal domain of SPAR protein; pfam11881"
                     /db_xref="CDD:463383"
     Region          1737..1792
                     /region_name="ZapB"
                     /note="Cell division protein ZapB; pfam06005"
                     /db_xref="CDD:428718"
     CDS             1..1804
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /coded_by="XM_047431218.1:914..6328"
                     /db_xref="GeneID:26037"
                     /db_xref="HGNC:HGNC:20284"
                     /db_xref="MIM:617504"
ORIGIN      
        1 mtslkrsqte rplatdrasv vgtdgtpkvh tddfymrrfr sqngslgssv mapvgpprse
       61 gshhitstpg vpkmgvrari adwpprkeni kessrssqei etsscldsls sksspvsqgs
      121 svslnsndsa mlksiqntlk nktrpsenmd srflmpeayp ssprkalrri rqrsnsditi
      181 seldvdsfde cisptyktgp slhreygsts sidkqgtsge sffdllkgyk ddksdrgptp
      241 tklsdflitg ggkgsgfsld vidgpisqre nlrlfkerek plkrrskset gdssifrklr
      301 nakgeelgks sdlednrsed svrpwtcpkc fahydvqsil fdlneaimnr hnvikrrntt
      361 tgasaaavas lvsgplshsa sfsspmgste dlnskgslsm dqgddksnel vmscpyfrne
      421 iggegerkis lsksnsgsfs gcesasfest lsshctnagv avlevpkenl vlhldrvkry
      481 ivehvdlgay yyrkffyqke hwnyfgaden lgpvavsirr ekpdemkeng spynyriifr
      541 tselmtlrgs vledaipsta khstarglpl kevlehvvpe lnvqclrlaf ntpkvteqlm
      601 kldeqglnyq qkvgimycka gqsteeemyn nesagpafee flqllgervr lkgfekyraq
      661 ldtktdstgt hslyttykdy eimfhvstml pytpnnkqql lrkrhigndi vtivfqepga
      721 qpfspknirs hfqhvfvivr vhnpcsdsvc ysvavtrsrd vpsfgppipk gvtfpksnvf
      781 rdfllakvin aenaahksek framatrtrq eylkdlaekn vtntpidpsg kfpfislask
      841 kkekskpypg aelssmgaiv wavraedynk ameldcllgi snefivlieq etksvvfncs
      901 crdvigwtst dtslkifyer gecvsvgsfi nieeikeivk rlqfvskgce svemtlrrng
      961 lgqlgfhvny egivadvepy gyawqaglrq gsrlveickv avatlsheqm idllrtsvtv
     1021 kvviipphdd ctprrscset yrmpvmeykm negvsyefkf pfrnnnkwqr naskgphspq
     1081 vpsqvqspmt srlnagkgdg kmppperaan iprsissdgr plerrlspgs diyvtvssma
     1141 larsqcrnsp snlssssdtg svggtyrqks mpegfgvsrr spasidrqnt qsdiggsgks
     1201 tpswqrseds iadqmaysyr gpqdfnsfvl eqheyteptc hlpavskvlp afrespsgrl
     1261 mrqdpvvhls pnkqghsdsh ysshsssntl ssnassahsd ekwydgdrte selnsynylq
     1321 gtsadsgidt tsygpshgst aslgaatssp rsgpgkekva plwhsssevi smadrtlete
     1381 shgldrktes slsldihsks qagstpltre nstfsindaa shtstmssrh saspvvftsa
     1441 rsspkeelhp aapsqlapsf ssssssssgp rsfyprqgat skyligwkkp egtinsvgfm
     1501 dtrkrhqsdg neiahtrlra strdlraspk ptskstieed lkklidlesp tpesqksfkf
     1561 halsspqspf pstptsrral hrtlsdesiy nsqrehffts raslldqalp ndvlfsstyp
     1621 slpkslplrr psytlgmksl hgefsasdss ltdiqetrrq pmpdpglmpl pdtaadldws
     1681 nlvdaakaye vqrasffaas denhrplsaa snsdqledqa laqmkpysss kdssptlask
     1741 vdqlegmlkm lredlkkeke dkahlqaevq hlrednlrlq eesqnasdkl kkftewvfnt
     1801 idms
//
LOCUS       XP_047287175            1804 aa            linear   PRI 05-AUG-2025
DEFINITION  signal-induced proliferation-associated 1-like protein 1 isoform X1
            [Homo sapiens].
ACCESSION   XP_047287175
VERSION     XP_047287175.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431219.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1804
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1804
                     /product="signal-induced proliferation-associated 1-like
                     protein 1 isoform X1"
                     /calculated_mol_wt=199898
     Region          629..809
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     Region          953..1025
                     /region_name="PDZ_SIPA1-like"
                     /note="PDZ domain of signal-induced
                     proliferation-associated protein 1 (SIPA1), and related
                     domains; cd06745"
                     /db_xref="CDD:467227"
     Site            order(963..969,975,978,1007,1011,1014..1015)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467227"
     Region          1504..1749
                     /region_name="SPAR_C"
                     /note="C-terminal domain of SPAR protein; pfam11881"
                     /db_xref="CDD:463383"
     Region          1737..1792
                     /region_name="ZapB"
                     /note="Cell division protein ZapB; pfam06005"
                     /db_xref="CDD:428718"
     CDS             1..1804
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /coded_by="XM_047431219.1:673..6087"
                     /db_xref="GeneID:26037"
                     /db_xref="HGNC:HGNC:20284"
                     /db_xref="MIM:617504"
ORIGIN      
        1 mtslkrsqte rplatdrasv vgtdgtpkvh tddfymrrfr sqngslgssv mapvgpprse
       61 gshhitstpg vpkmgvrari adwpprkeni kessrssqei etsscldsls sksspvsqgs
      121 svslnsndsa mlksiqntlk nktrpsenmd srflmpeayp ssprkalrri rqrsnsditi
      181 seldvdsfde cisptyktgp slhreygsts sidkqgtsge sffdllkgyk ddksdrgptp
      241 tklsdflitg ggkgsgfsld vidgpisqre nlrlfkerek plkrrskset gdssifrklr
      301 nakgeelgks sdlednrsed svrpwtcpkc fahydvqsil fdlneaimnr hnvikrrntt
      361 tgasaaavas lvsgplshsa sfsspmgste dlnskgslsm dqgddksnel vmscpyfrne
      421 iggegerkis lsksnsgsfs gcesasfest lsshctnagv avlevpkenl vlhldrvkry
      481 ivehvdlgay yyrkffyqke hwnyfgaden lgpvavsirr ekpdemkeng spynyriifr
      541 tselmtlrgs vledaipsta khstarglpl kevlehvvpe lnvqclrlaf ntpkvteqlm
      601 kldeqglnyq qkvgimycka gqsteeemyn nesagpafee flqllgervr lkgfekyraq
      661 ldtktdstgt hslyttykdy eimfhvstml pytpnnkqql lrkrhigndi vtivfqepga
      721 qpfspknirs hfqhvfvivr vhnpcsdsvc ysvavtrsrd vpsfgppipk gvtfpksnvf
      781 rdfllakvin aenaahksek framatrtrq eylkdlaekn vtntpidpsg kfpfislask
      841 kkekskpypg aelssmgaiv wavraedynk ameldcllgi snefivlieq etksvvfncs
      901 crdvigwtst dtslkifyer gecvsvgsfi nieeikeivk rlqfvskgce svemtlrrng
      961 lgqlgfhvny egivadvepy gyawqaglrq gsrlveickv avatlsheqm idllrtsvtv
     1021 kvviipphdd ctprrscset yrmpvmeykm negvsyefkf pfrnnnkwqr naskgphspq
     1081 vpsqvqspmt srlnagkgdg kmppperaan iprsissdgr plerrlspgs diyvtvssma
     1141 larsqcrnsp snlssssdtg svggtyrqks mpegfgvsrr spasidrqnt qsdiggsgks
     1201 tpswqrseds iadqmaysyr gpqdfnsfvl eqheyteptc hlpavskvlp afrespsgrl
     1261 mrqdpvvhls pnkqghsdsh ysshsssntl ssnassahsd ekwydgdrte selnsynylq
     1321 gtsadsgidt tsygpshgst aslgaatssp rsgpgkekva plwhsssevi smadrtlete
     1381 shgldrktes slsldihsks qagstpltre nstfsindaa shtstmssrh saspvvftsa
     1441 rsspkeelhp aapsqlapsf ssssssssgp rsfyprqgat skyligwkkp egtinsvgfm
     1501 dtrkrhqsdg neiahtrlra strdlraspk ptskstieed lkklidlesp tpesqksfkf
     1561 halsspqspf pstptsrral hrtlsdesiy nsqrehffts raslldqalp ndvlfsstyp
     1621 slpkslplrr psytlgmksl hgefsasdss ltdiqetrrq pmpdpglmpl pdtaadldws
     1681 nlvdaakaye vqrasffaas denhrplsaa snsdqledqa laqmkpysss kdssptlask
     1741 vdqlegmlkm lredlkkeke dkahlqaevq hlrednlrlq eesqnasdkl kkftewvfnt
     1801 idms
//
LOCUS       XP_047287176            1804 aa            linear   PRI 05-AUG-2025
DEFINITION  signal-induced proliferation-associated 1-like protein 1 isoform X1
            [Homo sapiens].
ACCESSION   XP_047287176
VERSION     XP_047287176.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431220.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1804
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1804
                     /product="signal-induced proliferation-associated 1-like
                     protein 1 isoform X1"
                     /calculated_mol_wt=199898
     Region          629..809
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     Region          953..1025
                     /region_name="PDZ_SIPA1-like"
                     /note="PDZ domain of signal-induced
                     proliferation-associated protein 1 (SIPA1), and related
                     domains; cd06745"
                     /db_xref="CDD:467227"
     Site            order(963..969,975,978,1007,1011,1014..1015)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467227"
     Region          1504..1749
                     /region_name="SPAR_C"
                     /note="C-terminal domain of SPAR protein; pfam11881"
                     /db_xref="CDD:463383"
     Region          1737..1792
                     /region_name="ZapB"
                     /note="Cell division protein ZapB; pfam06005"
                     /db_xref="CDD:428718"
     CDS             1..1804
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /coded_by="XM_047431220.1:29640..35054"
                     /db_xref="GeneID:26037"
                     /db_xref="HGNC:HGNC:20284"
                     /db_xref="MIM:617504"
ORIGIN      
        1 mtslkrsqte rplatdrasv vgtdgtpkvh tddfymrrfr sqngslgssv mapvgpprse
       61 gshhitstpg vpkmgvrari adwpprkeni kessrssqei etsscldsls sksspvsqgs
      121 svslnsndsa mlksiqntlk nktrpsenmd srflmpeayp ssprkalrri rqrsnsditi
      181 seldvdsfde cisptyktgp slhreygsts sidkqgtsge sffdllkgyk ddksdrgptp
      241 tklsdflitg ggkgsgfsld vidgpisqre nlrlfkerek plkrrskset gdssifrklr
      301 nakgeelgks sdlednrsed svrpwtcpkc fahydvqsil fdlneaimnr hnvikrrntt
      361 tgasaaavas lvsgplshsa sfsspmgste dlnskgslsm dqgddksnel vmscpyfrne
      421 iggegerkis lsksnsgsfs gcesasfest lsshctnagv avlevpkenl vlhldrvkry
      481 ivehvdlgay yyrkffyqke hwnyfgaden lgpvavsirr ekpdemkeng spynyriifr
      541 tselmtlrgs vledaipsta khstarglpl kevlehvvpe lnvqclrlaf ntpkvteqlm
      601 kldeqglnyq qkvgimycka gqsteeemyn nesagpafee flqllgervr lkgfekyraq
      661 ldtktdstgt hslyttykdy eimfhvstml pytpnnkqql lrkrhigndi vtivfqepga
      721 qpfspknirs hfqhvfvivr vhnpcsdsvc ysvavtrsrd vpsfgppipk gvtfpksnvf
      781 rdfllakvin aenaahksek framatrtrq eylkdlaekn vtntpidpsg kfpfislask
      841 kkekskpypg aelssmgaiv wavraedynk ameldcllgi snefivlieq etksvvfncs
      901 crdvigwtst dtslkifyer gecvsvgsfi nieeikeivk rlqfvskgce svemtlrrng
      961 lgqlgfhvny egivadvepy gyawqaglrq gsrlveickv avatlsheqm idllrtsvtv
     1021 kvviipphdd ctprrscset yrmpvmeykm negvsyefkf pfrnnnkwqr naskgphspq
     1081 vpsqvqspmt srlnagkgdg kmppperaan iprsissdgr plerrlspgs diyvtvssma
     1141 larsqcrnsp snlssssdtg svggtyrqks mpegfgvsrr spasidrqnt qsdiggsgks
     1201 tpswqrseds iadqmaysyr gpqdfnsfvl eqheyteptc hlpavskvlp afrespsgrl
     1261 mrqdpvvhls pnkqghsdsh ysshsssntl ssnassahsd ekwydgdrte selnsynylq
     1321 gtsadsgidt tsygpshgst aslgaatssp rsgpgkekva plwhsssevi smadrtlete
     1381 shgldrktes slsldihsks qagstpltre nstfsindaa shtstmssrh saspvvftsa
     1441 rsspkeelhp aapsqlapsf ssssssssgp rsfyprqgat skyligwkkp egtinsvgfm
     1501 dtrkrhqsdg neiahtrlra strdlraspk ptskstieed lkklidlesp tpesqksfkf
     1561 halsspqspf pstptsrral hrtlsdesiy nsqrehffts raslldqalp ndvlfsstyp
     1621 slpkslplrr psytlgmksl hgefsasdss ltdiqetrrq pmpdpglmpl pdtaadldws
     1681 nlvdaakaye vqrasffaas denhrplsaa snsdqledqa laqmkpysss kdssptlask
     1741 vdqlegmlkm lredlkkeke dkahlqaevq hlrednlrlq eesqnasdkl kkftewvfnt
     1801 idms
//
LOCUS       XP_047287178            1804 aa            linear   PRI 05-AUG-2025
DEFINITION  signal-induced proliferation-associated 1-like protein 1 isoform X1
            [Homo sapiens].
ACCESSION   XP_047287178
VERSION     XP_047287178.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431222.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1804
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1804
                     /product="signal-induced proliferation-associated 1-like
                     protein 1 isoform X1"
                     /calculated_mol_wt=199898
     Region          629..809
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     Region          953..1025
                     /region_name="PDZ_SIPA1-like"
                     /note="PDZ domain of signal-induced
                     proliferation-associated protein 1 (SIPA1), and related
                     domains; cd06745"
                     /db_xref="CDD:467227"
     Site            order(963..969,975,978,1007,1011,1014..1015)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467227"
     Region          1504..1749
                     /region_name="SPAR_C"
                     /note="C-terminal domain of SPAR protein; pfam11881"
                     /db_xref="CDD:463383"
     Region          1737..1792
                     /region_name="ZapB"
                     /note="Cell division protein ZapB; pfam06005"
                     /db_xref="CDD:428718"
     CDS             1..1804
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /coded_by="XM_047431222.1:2241..7655"
                     /db_xref="GeneID:26037"
                     /db_xref="HGNC:HGNC:20284"
                     /db_xref="MIM:617504"
ORIGIN      
        1 mtslkrsqte rplatdrasv vgtdgtpkvh tddfymrrfr sqngslgssv mapvgpprse
       61 gshhitstpg vpkmgvrari adwpprkeni kessrssqei etsscldsls sksspvsqgs
      121 svslnsndsa mlksiqntlk nktrpsenmd srflmpeayp ssprkalrri rqrsnsditi
      181 seldvdsfde cisptyktgp slhreygsts sidkqgtsge sffdllkgyk ddksdrgptp
      241 tklsdflitg ggkgsgfsld vidgpisqre nlrlfkerek plkrrskset gdssifrklr
      301 nakgeelgks sdlednrsed svrpwtcpkc fahydvqsil fdlneaimnr hnvikrrntt
      361 tgasaaavas lvsgplshsa sfsspmgste dlnskgslsm dqgddksnel vmscpyfrne
      421 iggegerkis lsksnsgsfs gcesasfest lsshctnagv avlevpkenl vlhldrvkry
      481 ivehvdlgay yyrkffyqke hwnyfgaden lgpvavsirr ekpdemkeng spynyriifr
      541 tselmtlrgs vledaipsta khstarglpl kevlehvvpe lnvqclrlaf ntpkvteqlm
      601 kldeqglnyq qkvgimycka gqsteeemyn nesagpafee flqllgervr lkgfekyraq
      661 ldtktdstgt hslyttykdy eimfhvstml pytpnnkqql lrkrhigndi vtivfqepga
      721 qpfspknirs hfqhvfvivr vhnpcsdsvc ysvavtrsrd vpsfgppipk gvtfpksnvf
      781 rdfllakvin aenaahksek framatrtrq eylkdlaekn vtntpidpsg kfpfislask
      841 kkekskpypg aelssmgaiv wavraedynk ameldcllgi snefivlieq etksvvfncs
      901 crdvigwtst dtslkifyer gecvsvgsfi nieeikeivk rlqfvskgce svemtlrrng
      961 lgqlgfhvny egivadvepy gyawqaglrq gsrlveickv avatlsheqm idllrtsvtv
     1021 kvviipphdd ctprrscset yrmpvmeykm negvsyefkf pfrnnnkwqr naskgphspq
     1081 vpsqvqspmt srlnagkgdg kmppperaan iprsissdgr plerrlspgs diyvtvssma
     1141 larsqcrnsp snlssssdtg svggtyrqks mpegfgvsrr spasidrqnt qsdiggsgks
     1201 tpswqrseds iadqmaysyr gpqdfnsfvl eqheyteptc hlpavskvlp afrespsgrl
     1261 mrqdpvvhls pnkqghsdsh ysshsssntl ssnassahsd ekwydgdrte selnsynylq
     1321 gtsadsgidt tsygpshgst aslgaatssp rsgpgkekva plwhsssevi smadrtlete
     1381 shgldrktes slsldihsks qagstpltre nstfsindaa shtstmssrh saspvvftsa
     1441 rsspkeelhp aapsqlapsf ssssssssgp rsfyprqgat skyligwkkp egtinsvgfm
     1501 dtrkrhqsdg neiahtrlra strdlraspk ptskstieed lkklidlesp tpesqksfkf
     1561 halsspqspf pstptsrral hrtlsdesiy nsqrehffts raslldqalp ndvlfsstyp
     1621 slpkslplrr psytlgmksl hgefsasdss ltdiqetrrq pmpdpglmpl pdtaadldws
     1681 nlvdaakaye vqrasffaas denhrplsaa snsdqledqa laqmkpysss kdssptlask
     1741 vdqlegmlkm lredlkkeke dkahlqaevq hlrednlrlq eesqnasdkl kkftewvfnt
     1801 idms
//
LOCUS       XP_047287179            1804 aa            linear   PRI 05-AUG-2025
DEFINITION  signal-induced proliferation-associated 1-like protein 1 isoform X1
            [Homo sapiens].
ACCESSION   XP_047287179
VERSION     XP_047287179.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431223.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1804
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1804
                     /product="signal-induced proliferation-associated 1-like
                     protein 1 isoform X1"
                     /calculated_mol_wt=199898
     Region          629..809
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     Region          953..1025
                     /region_name="PDZ_SIPA1-like"
                     /note="PDZ domain of signal-induced
                     proliferation-associated protein 1 (SIPA1), and related
                     domains; cd06745"
                     /db_xref="CDD:467227"
     Site            order(963..969,975,978,1007,1011,1014..1015)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467227"
     Region          1504..1749
                     /region_name="SPAR_C"
                     /note="C-terminal domain of SPAR protein; pfam11881"
                     /db_xref="CDD:463383"
     Region          1737..1792
                     /region_name="ZapB"
                     /note="Cell division protein ZapB; pfam06005"
                     /db_xref="CDD:428718"
     CDS             1..1804
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /coded_by="XM_047431223.1:1076..6490"
                     /db_xref="GeneID:26037"
                     /db_xref="HGNC:HGNC:20284"
                     /db_xref="MIM:617504"
ORIGIN      
        1 mtslkrsqte rplatdrasv vgtdgtpkvh tddfymrrfr sqngslgssv mapvgpprse
       61 gshhitstpg vpkmgvrari adwpprkeni kessrssqei etsscldsls sksspvsqgs
      121 svslnsndsa mlksiqntlk nktrpsenmd srflmpeayp ssprkalrri rqrsnsditi
      181 seldvdsfde cisptyktgp slhreygsts sidkqgtsge sffdllkgyk ddksdrgptp
      241 tklsdflitg ggkgsgfsld vidgpisqre nlrlfkerek plkrrskset gdssifrklr
      301 nakgeelgks sdlednrsed svrpwtcpkc fahydvqsil fdlneaimnr hnvikrrntt
      361 tgasaaavas lvsgplshsa sfsspmgste dlnskgslsm dqgddksnel vmscpyfrne
      421 iggegerkis lsksnsgsfs gcesasfest lsshctnagv avlevpkenl vlhldrvkry
      481 ivehvdlgay yyrkffyqke hwnyfgaden lgpvavsirr ekpdemkeng spynyriifr
      541 tselmtlrgs vledaipsta khstarglpl kevlehvvpe lnvqclrlaf ntpkvteqlm
      601 kldeqglnyq qkvgimycka gqsteeemyn nesagpafee flqllgervr lkgfekyraq
      661 ldtktdstgt hslyttykdy eimfhvstml pytpnnkqql lrkrhigndi vtivfqepga
      721 qpfspknirs hfqhvfvivr vhnpcsdsvc ysvavtrsrd vpsfgppipk gvtfpksnvf
      781 rdfllakvin aenaahksek framatrtrq eylkdlaekn vtntpidpsg kfpfislask
      841 kkekskpypg aelssmgaiv wavraedynk ameldcllgi snefivlieq etksvvfncs
      901 crdvigwtst dtslkifyer gecvsvgsfi nieeikeivk rlqfvskgce svemtlrrng
      961 lgqlgfhvny egivadvepy gyawqaglrq gsrlveickv avatlsheqm idllrtsvtv
     1021 kvviipphdd ctprrscset yrmpvmeykm negvsyefkf pfrnnnkwqr naskgphspq
     1081 vpsqvqspmt srlnagkgdg kmppperaan iprsissdgr plerrlspgs diyvtvssma
     1141 larsqcrnsp snlssssdtg svggtyrqks mpegfgvsrr spasidrqnt qsdiggsgks
     1201 tpswqrseds iadqmaysyr gpqdfnsfvl eqheyteptc hlpavskvlp afrespsgrl
     1261 mrqdpvvhls pnkqghsdsh ysshsssntl ssnassahsd ekwydgdrte selnsynylq
     1321 gtsadsgidt tsygpshgst aslgaatssp rsgpgkekva plwhsssevi smadrtlete
     1381 shgldrktes slsldihsks qagstpltre nstfsindaa shtstmssrh saspvvftsa
     1441 rsspkeelhp aapsqlapsf ssssssssgp rsfyprqgat skyligwkkp egtinsvgfm
     1501 dtrkrhqsdg neiahtrlra strdlraspk ptskstieed lkklidlesp tpesqksfkf
     1561 halsspqspf pstptsrral hrtlsdesiy nsqrehffts raslldqalp ndvlfsstyp
     1621 slpkslplrr psytlgmksl hgefsasdss ltdiqetrrq pmpdpglmpl pdtaadldws
     1681 nlvdaakaye vqrasffaas denhrplsaa snsdqledqa laqmkpysss kdssptlask
     1741 vdqlegmlkm lredlkkeke dkahlqaevq hlrednlrlq eesqnasdkl kkftewvfnt
     1801 idms
//
LOCUS       XP_047287180            1804 aa            linear   PRI 05-AUG-2025
DEFINITION  signal-induced proliferation-associated 1-like protein 1 isoform X1
            [Homo sapiens].
ACCESSION   XP_047287180
VERSION     XP_047287180.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431224.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1804
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1804
                     /product="signal-induced proliferation-associated 1-like
                     protein 1 isoform X1"
                     /calculated_mol_wt=199898
     Region          629..809
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     Region          953..1025
                     /region_name="PDZ_SIPA1-like"
                     /note="PDZ domain of signal-induced
                     proliferation-associated protein 1 (SIPA1), and related
                     domains; cd06745"
                     /db_xref="CDD:467227"
     Site            order(963..969,975,978,1007,1011,1014..1015)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467227"
     Region          1504..1749
                     /region_name="SPAR_C"
                     /note="C-terminal domain of SPAR protein; pfam11881"
                     /db_xref="CDD:463383"
     Region          1737..1792
                     /region_name="ZapB"
                     /note="Cell division protein ZapB; pfam06005"
                     /db_xref="CDD:428718"
     CDS             1..1804
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /coded_by="XM_047431224.1:712..6126"
                     /db_xref="GeneID:26037"
                     /db_xref="HGNC:HGNC:20284"
                     /db_xref="MIM:617504"
ORIGIN      
        1 mtslkrsqte rplatdrasv vgtdgtpkvh tddfymrrfr sqngslgssv mapvgpprse
       61 gshhitstpg vpkmgvrari adwpprkeni kessrssqei etsscldsls sksspvsqgs
      121 svslnsndsa mlksiqntlk nktrpsenmd srflmpeayp ssprkalrri rqrsnsditi
      181 seldvdsfde cisptyktgp slhreygsts sidkqgtsge sffdllkgyk ddksdrgptp
      241 tklsdflitg ggkgsgfsld vidgpisqre nlrlfkerek plkrrskset gdssifrklr
      301 nakgeelgks sdlednrsed svrpwtcpkc fahydvqsil fdlneaimnr hnvikrrntt
      361 tgasaaavas lvsgplshsa sfsspmgste dlnskgslsm dqgddksnel vmscpyfrne
      421 iggegerkis lsksnsgsfs gcesasfest lsshctnagv avlevpkenl vlhldrvkry
      481 ivehvdlgay yyrkffyqke hwnyfgaden lgpvavsirr ekpdemkeng spynyriifr
      541 tselmtlrgs vledaipsta khstarglpl kevlehvvpe lnvqclrlaf ntpkvteqlm
      601 kldeqglnyq qkvgimycka gqsteeemyn nesagpafee flqllgervr lkgfekyraq
      661 ldtktdstgt hslyttykdy eimfhvstml pytpnnkqql lrkrhigndi vtivfqepga
      721 qpfspknirs hfqhvfvivr vhnpcsdsvc ysvavtrsrd vpsfgppipk gvtfpksnvf
      781 rdfllakvin aenaahksek framatrtrq eylkdlaekn vtntpidpsg kfpfislask
      841 kkekskpypg aelssmgaiv wavraedynk ameldcllgi snefivlieq etksvvfncs
      901 crdvigwtst dtslkifyer gecvsvgsfi nieeikeivk rlqfvskgce svemtlrrng
      961 lgqlgfhvny egivadvepy gyawqaglrq gsrlveickv avatlsheqm idllrtsvtv
     1021 kvviipphdd ctprrscset yrmpvmeykm negvsyefkf pfrnnnkwqr naskgphspq
     1081 vpsqvqspmt srlnagkgdg kmppperaan iprsissdgr plerrlspgs diyvtvssma
     1141 larsqcrnsp snlssssdtg svggtyrqks mpegfgvsrr spasidrqnt qsdiggsgks
     1201 tpswqrseds iadqmaysyr gpqdfnsfvl eqheyteptc hlpavskvlp afrespsgrl
     1261 mrqdpvvhls pnkqghsdsh ysshsssntl ssnassahsd ekwydgdrte selnsynylq
     1321 gtsadsgidt tsygpshgst aslgaatssp rsgpgkekva plwhsssevi smadrtlete
     1381 shgldrktes slsldihsks qagstpltre nstfsindaa shtstmssrh saspvvftsa
     1441 rsspkeelhp aapsqlapsf ssssssssgp rsfyprqgat skyligwkkp egtinsvgfm
     1501 dtrkrhqsdg neiahtrlra strdlraspk ptskstieed lkklidlesp tpesqksfkf
     1561 halsspqspf pstptsrral hrtlsdesiy nsqrehffts raslldqalp ndvlfsstyp
     1621 slpkslplrr psytlgmksl hgefsasdss ltdiqetrrq pmpdpglmpl pdtaadldws
     1681 nlvdaakaye vqrasffaas denhrplsaa snsdqledqa laqmkpysss kdssptlask
     1741 vdqlegmlkm lredlkkeke dkahlqaevq hlrednlrlq eesqnasdkl kkftewvfnt
     1801 idms
//
LOCUS       XP_047287181            1804 aa            linear   PRI 05-AUG-2025
DEFINITION  signal-induced proliferation-associated 1-like protein 1 isoform X1
            [Homo sapiens].
ACCESSION   XP_047287181
VERSION     XP_047287181.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431225.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1804
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1804
                     /product="signal-induced proliferation-associated 1-like
                     protein 1 isoform X1"
                     /calculated_mol_wt=199898
     Region          629..809
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     Region          953..1025
                     /region_name="PDZ_SIPA1-like"
                     /note="PDZ domain of signal-induced
                     proliferation-associated protein 1 (SIPA1), and related
                     domains; cd06745"
                     /db_xref="CDD:467227"
     Site            order(963..969,975,978,1007,1011,1014..1015)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467227"
     Region          1504..1749
                     /region_name="SPAR_C"
                     /note="C-terminal domain of SPAR protein; pfam11881"
                     /db_xref="CDD:463383"
     Region          1737..1792
                     /region_name="ZapB"
                     /note="Cell division protein ZapB; pfam06005"
                     /db_xref="CDD:428718"
     CDS             1..1804
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /coded_by="XM_047431225.1:2185..7599"
                     /db_xref="GeneID:26037"
                     /db_xref="HGNC:HGNC:20284"
                     /db_xref="MIM:617504"
ORIGIN      
        1 mtslkrsqte rplatdrasv vgtdgtpkvh tddfymrrfr sqngslgssv mapvgpprse
       61 gshhitstpg vpkmgvrari adwpprkeni kessrssqei etsscldsls sksspvsqgs
      121 svslnsndsa mlksiqntlk nktrpsenmd srflmpeayp ssprkalrri rqrsnsditi
      181 seldvdsfde cisptyktgp slhreygsts sidkqgtsge sffdllkgyk ddksdrgptp
      241 tklsdflitg ggkgsgfsld vidgpisqre nlrlfkerek plkrrskset gdssifrklr
      301 nakgeelgks sdlednrsed svrpwtcpkc fahydvqsil fdlneaimnr hnvikrrntt
      361 tgasaaavas lvsgplshsa sfsspmgste dlnskgslsm dqgddksnel vmscpyfrne
      421 iggegerkis lsksnsgsfs gcesasfest lsshctnagv avlevpkenl vlhldrvkry
      481 ivehvdlgay yyrkffyqke hwnyfgaden lgpvavsirr ekpdemkeng spynyriifr
      541 tselmtlrgs vledaipsta khstarglpl kevlehvvpe lnvqclrlaf ntpkvteqlm
      601 kldeqglnyq qkvgimycka gqsteeemyn nesagpafee flqllgervr lkgfekyraq
      661 ldtktdstgt hslyttykdy eimfhvstml pytpnnkqql lrkrhigndi vtivfqepga
      721 qpfspknirs hfqhvfvivr vhnpcsdsvc ysvavtrsrd vpsfgppipk gvtfpksnvf
      781 rdfllakvin aenaahksek framatrtrq eylkdlaekn vtntpidpsg kfpfislask
      841 kkekskpypg aelssmgaiv wavraedynk ameldcllgi snefivlieq etksvvfncs
      901 crdvigwtst dtslkifyer gecvsvgsfi nieeikeivk rlqfvskgce svemtlrrng
      961 lgqlgfhvny egivadvepy gyawqaglrq gsrlveickv avatlsheqm idllrtsvtv
     1021 kvviipphdd ctprrscset yrmpvmeykm negvsyefkf pfrnnnkwqr naskgphspq
     1081 vpsqvqspmt srlnagkgdg kmppperaan iprsissdgr plerrlspgs diyvtvssma
     1141 larsqcrnsp snlssssdtg svggtyrqks mpegfgvsrr spasidrqnt qsdiggsgks
     1201 tpswqrseds iadqmaysyr gpqdfnsfvl eqheyteptc hlpavskvlp afrespsgrl
     1261 mrqdpvvhls pnkqghsdsh ysshsssntl ssnassahsd ekwydgdrte selnsynylq
     1321 gtsadsgidt tsygpshgst aslgaatssp rsgpgkekva plwhsssevi smadrtlete
     1381 shgldrktes slsldihsks qagstpltre nstfsindaa shtstmssrh saspvvftsa
     1441 rsspkeelhp aapsqlapsf ssssssssgp rsfyprqgat skyligwkkp egtinsvgfm
     1501 dtrkrhqsdg neiahtrlra strdlraspk ptskstieed lkklidlesp tpesqksfkf
     1561 halsspqspf pstptsrral hrtlsdesiy nsqrehffts raslldqalp ndvlfsstyp
     1621 slpkslplrr psytlgmksl hgefsasdss ltdiqetrrq pmpdpglmpl pdtaadldws
     1681 nlvdaakaye vqrasffaas denhrplsaa snsdqledqa laqmkpysss kdssptlask
     1741 vdqlegmlkm lredlkkeke dkahlqaevq hlrednlrlq eesqnasdkl kkftewvfnt
     1801 idms
//
LOCUS       XP_047287182            1804 aa            linear   PRI 05-AUG-2025
DEFINITION  signal-induced proliferation-associated 1-like protein 1 isoform X1
            [Homo sapiens].
ACCESSION   XP_047287182
VERSION     XP_047287182.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431226.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1804
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1804
                     /product="signal-induced proliferation-associated 1-like
                     protein 1 isoform X1"
                     /calculated_mol_wt=199898
     Region          629..809
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     Region          953..1025
                     /region_name="PDZ_SIPA1-like"
                     /note="PDZ domain of signal-induced
                     proliferation-associated protein 1 (SIPA1), and related
                     domains; cd06745"
                     /db_xref="CDD:467227"
     Site            order(963..969,975,978,1007,1011,1014..1015)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467227"
     Region          1504..1749
                     /region_name="SPAR_C"
                     /note="C-terminal domain of SPAR protein; pfam11881"
                     /db_xref="CDD:463383"
     Region          1737..1792
                     /region_name="ZapB"
                     /note="Cell division protein ZapB; pfam06005"
                     /db_xref="CDD:428718"
     CDS             1..1804
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /coded_by="XM_047431226.1:2351..7765"
                     /db_xref="GeneID:26037"
                     /db_xref="HGNC:HGNC:20284"
                     /db_xref="MIM:617504"
ORIGIN      
        1 mtslkrsqte rplatdrasv vgtdgtpkvh tddfymrrfr sqngslgssv mapvgpprse
       61 gshhitstpg vpkmgvrari adwpprkeni kessrssqei etsscldsls sksspvsqgs
      121 svslnsndsa mlksiqntlk nktrpsenmd srflmpeayp ssprkalrri rqrsnsditi
      181 seldvdsfde cisptyktgp slhreygsts sidkqgtsge sffdllkgyk ddksdrgptp
      241 tklsdflitg ggkgsgfsld vidgpisqre nlrlfkerek plkrrskset gdssifrklr
      301 nakgeelgks sdlednrsed svrpwtcpkc fahydvqsil fdlneaimnr hnvikrrntt
      361 tgasaaavas lvsgplshsa sfsspmgste dlnskgslsm dqgddksnel vmscpyfrne
      421 iggegerkis lsksnsgsfs gcesasfest lsshctnagv avlevpkenl vlhldrvkry
      481 ivehvdlgay yyrkffyqke hwnyfgaden lgpvavsirr ekpdemkeng spynyriifr
      541 tselmtlrgs vledaipsta khstarglpl kevlehvvpe lnvqclrlaf ntpkvteqlm
      601 kldeqglnyq qkvgimycka gqsteeemyn nesagpafee flqllgervr lkgfekyraq
      661 ldtktdstgt hslyttykdy eimfhvstml pytpnnkqql lrkrhigndi vtivfqepga
      721 qpfspknirs hfqhvfvivr vhnpcsdsvc ysvavtrsrd vpsfgppipk gvtfpksnvf
      781 rdfllakvin aenaahksek framatrtrq eylkdlaekn vtntpidpsg kfpfislask
      841 kkekskpypg aelssmgaiv wavraedynk ameldcllgi snefivlieq etksvvfncs
      901 crdvigwtst dtslkifyer gecvsvgsfi nieeikeivk rlqfvskgce svemtlrrng
      961 lgqlgfhvny egivadvepy gyawqaglrq gsrlveickv avatlsheqm idllrtsvtv
     1021 kvviipphdd ctprrscset yrmpvmeykm negvsyefkf pfrnnnkwqr naskgphspq
     1081 vpsqvqspmt srlnagkgdg kmppperaan iprsissdgr plerrlspgs diyvtvssma
     1141 larsqcrnsp snlssssdtg svggtyrqks mpegfgvsrr spasidrqnt qsdiggsgks
     1201 tpswqrseds iadqmaysyr gpqdfnsfvl eqheyteptc hlpavskvlp afrespsgrl
     1261 mrqdpvvhls pnkqghsdsh ysshsssntl ssnassahsd ekwydgdrte selnsynylq
     1321 gtsadsgidt tsygpshgst aslgaatssp rsgpgkekva plwhsssevi smadrtlete
     1381 shgldrktes slsldihsks qagstpltre nstfsindaa shtstmssrh saspvvftsa
     1441 rsspkeelhp aapsqlapsf ssssssssgp rsfyprqgat skyligwkkp egtinsvgfm
     1501 dtrkrhqsdg neiahtrlra strdlraspk ptskstieed lkklidlesp tpesqksfkf
     1561 halsspqspf pstptsrral hrtlsdesiy nsqrehffts raslldqalp ndvlfsstyp
     1621 slpkslplrr psytlgmksl hgefsasdss ltdiqetrrq pmpdpglmpl pdtaadldws
     1681 nlvdaakaye vqrasffaas denhrplsaa snsdqledqa laqmkpysss kdssptlask
     1741 vdqlegmlkm lredlkkeke dkahlqaevq hlrednlrlq eesqnasdkl kkftewvfnt
     1801 idms
//
LOCUS       XP_047287183            1804 aa            linear   PRI 05-AUG-2025
DEFINITION  signal-induced proliferation-associated 1-like protein 1 isoform X1
            [Homo sapiens].
ACCESSION   XP_047287183
VERSION     XP_047287183.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431227.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1804
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1804
                     /product="signal-induced proliferation-associated 1-like
                     protein 1 isoform X1"
                     /calculated_mol_wt=199898
     Region          629..809
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     Region          953..1025
                     /region_name="PDZ_SIPA1-like"
                     /note="PDZ domain of signal-induced
                     proliferation-associated protein 1 (SIPA1), and related
                     domains; cd06745"
                     /db_xref="CDD:467227"
     Site            order(963..969,975,978,1007,1011,1014..1015)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467227"
     Region          1504..1749
                     /region_name="SPAR_C"
                     /note="C-terminal domain of SPAR protein; pfam11881"
                     /db_xref="CDD:463383"
     Region          1737..1792
                     /region_name="ZapB"
                     /note="Cell division protein ZapB; pfam06005"
                     /db_xref="CDD:428718"
     CDS             1..1804
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /coded_by="XM_047431227.1:2298..7712"
                     /db_xref="GeneID:26037"
                     /db_xref="HGNC:HGNC:20284"
                     /db_xref="MIM:617504"
ORIGIN      
        1 mtslkrsqte rplatdrasv vgtdgtpkvh tddfymrrfr sqngslgssv mapvgpprse
       61 gshhitstpg vpkmgvrari adwpprkeni kessrssqei etsscldsls sksspvsqgs
      121 svslnsndsa mlksiqntlk nktrpsenmd srflmpeayp ssprkalrri rqrsnsditi
      181 seldvdsfde cisptyktgp slhreygsts sidkqgtsge sffdllkgyk ddksdrgptp
      241 tklsdflitg ggkgsgfsld vidgpisqre nlrlfkerek plkrrskset gdssifrklr
      301 nakgeelgks sdlednrsed svrpwtcpkc fahydvqsil fdlneaimnr hnvikrrntt
      361 tgasaaavas lvsgplshsa sfsspmgste dlnskgslsm dqgddksnel vmscpyfrne
      421 iggegerkis lsksnsgsfs gcesasfest lsshctnagv avlevpkenl vlhldrvkry
      481 ivehvdlgay yyrkffyqke hwnyfgaden lgpvavsirr ekpdemkeng spynyriifr
      541 tselmtlrgs vledaipsta khstarglpl kevlehvvpe lnvqclrlaf ntpkvteqlm
      601 kldeqglnyq qkvgimycka gqsteeemyn nesagpafee flqllgervr lkgfekyraq
      661 ldtktdstgt hslyttykdy eimfhvstml pytpnnkqql lrkrhigndi vtivfqepga
      721 qpfspknirs hfqhvfvivr vhnpcsdsvc ysvavtrsrd vpsfgppipk gvtfpksnvf
      781 rdfllakvin aenaahksek framatrtrq eylkdlaekn vtntpidpsg kfpfislask
      841 kkekskpypg aelssmgaiv wavraedynk ameldcllgi snefivlieq etksvvfncs
      901 crdvigwtst dtslkifyer gecvsvgsfi nieeikeivk rlqfvskgce svemtlrrng
      961 lgqlgfhvny egivadvepy gyawqaglrq gsrlveickv avatlsheqm idllrtsvtv
     1021 kvviipphdd ctprrscset yrmpvmeykm negvsyefkf pfrnnnkwqr naskgphspq
     1081 vpsqvqspmt srlnagkgdg kmppperaan iprsissdgr plerrlspgs diyvtvssma
     1141 larsqcrnsp snlssssdtg svggtyrqks mpegfgvsrr spasidrqnt qsdiggsgks
     1201 tpswqrseds iadqmaysyr gpqdfnsfvl eqheyteptc hlpavskvlp afrespsgrl
     1261 mrqdpvvhls pnkqghsdsh ysshsssntl ssnassahsd ekwydgdrte selnsynylq
     1321 gtsadsgidt tsygpshgst aslgaatssp rsgpgkekva plwhsssevi smadrtlete
     1381 shgldrktes slsldihsks qagstpltre nstfsindaa shtstmssrh saspvvftsa
     1441 rsspkeelhp aapsqlapsf ssssssssgp rsfyprqgat skyligwkkp egtinsvgfm
     1501 dtrkrhqsdg neiahtrlra strdlraspk ptskstieed lkklidlesp tpesqksfkf
     1561 halsspqspf pstptsrral hrtlsdesiy nsqrehffts raslldqalp ndvlfsstyp
     1621 slpkslplrr psytlgmksl hgefsasdss ltdiqetrrq pmpdpglmpl pdtaadldws
     1681 nlvdaakaye vqrasffaas denhrplsaa snsdqledqa laqmkpysss kdssptlask
     1741 vdqlegmlkm lredlkkeke dkahlqaevq hlrednlrlq eesqnasdkl kkftewvfnt
     1801 idms
//
LOCUS       XP_047287184            1804 aa            linear   PRI 05-AUG-2025
DEFINITION  signal-induced proliferation-associated 1-like protein 1 isoform X1
            [Homo sapiens].
ACCESSION   XP_047287184
VERSION     XP_047287184.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431228.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1804
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1804
                     /product="signal-induced proliferation-associated 1-like
                     protein 1 isoform X1"
                     /calculated_mol_wt=199898
     Region          629..809
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     Region          953..1025
                     /region_name="PDZ_SIPA1-like"
                     /note="PDZ domain of signal-induced
                     proliferation-associated protein 1 (SIPA1), and related
                     domains; cd06745"
                     /db_xref="CDD:467227"
     Site            order(963..969,975,978,1007,1011,1014..1015)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467227"
     Region          1504..1749
                     /region_name="SPAR_C"
                     /note="C-terminal domain of SPAR protein; pfam11881"
                     /db_xref="CDD:463383"
     Region          1737..1792
                     /region_name="ZapB"
                     /note="Cell division protein ZapB; pfam06005"
                     /db_xref="CDD:428718"
     CDS             1..1804
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /coded_by="XM_047431228.1:2242..7656"
                     /db_xref="GeneID:26037"
                     /db_xref="HGNC:HGNC:20284"
                     /db_xref="MIM:617504"
ORIGIN      
        1 mtslkrsqte rplatdrasv vgtdgtpkvh tddfymrrfr sqngslgssv mapvgpprse
       61 gshhitstpg vpkmgvrari adwpprkeni kessrssqei etsscldsls sksspvsqgs
      121 svslnsndsa mlksiqntlk nktrpsenmd srflmpeayp ssprkalrri rqrsnsditi
      181 seldvdsfde cisptyktgp slhreygsts sidkqgtsge sffdllkgyk ddksdrgptp
      241 tklsdflitg ggkgsgfsld vidgpisqre nlrlfkerek plkrrskset gdssifrklr
      301 nakgeelgks sdlednrsed svrpwtcpkc fahydvqsil fdlneaimnr hnvikrrntt
      361 tgasaaavas lvsgplshsa sfsspmgste dlnskgslsm dqgddksnel vmscpyfrne
      421 iggegerkis lsksnsgsfs gcesasfest lsshctnagv avlevpkenl vlhldrvkry
      481 ivehvdlgay yyrkffyqke hwnyfgaden lgpvavsirr ekpdemkeng spynyriifr
      541 tselmtlrgs vledaipsta khstarglpl kevlehvvpe lnvqclrlaf ntpkvteqlm
      601 kldeqglnyq qkvgimycka gqsteeemyn nesagpafee flqllgervr lkgfekyraq
      661 ldtktdstgt hslyttykdy eimfhvstml pytpnnkqql lrkrhigndi vtivfqepga
      721 qpfspknirs hfqhvfvivr vhnpcsdsvc ysvavtrsrd vpsfgppipk gvtfpksnvf
      781 rdfllakvin aenaahksek framatrtrq eylkdlaekn vtntpidpsg kfpfislask
      841 kkekskpypg aelssmgaiv wavraedynk ameldcllgi snefivlieq etksvvfncs
      901 crdvigwtst dtslkifyer gecvsvgsfi nieeikeivk rlqfvskgce svemtlrrng
      961 lgqlgfhvny egivadvepy gyawqaglrq gsrlveickv avatlsheqm idllrtsvtv
     1021 kvviipphdd ctprrscset yrmpvmeykm negvsyefkf pfrnnnkwqr naskgphspq
     1081 vpsqvqspmt srlnagkgdg kmppperaan iprsissdgr plerrlspgs diyvtvssma
     1141 larsqcrnsp snlssssdtg svggtyrqks mpegfgvsrr spasidrqnt qsdiggsgks
     1201 tpswqrseds iadqmaysyr gpqdfnsfvl eqheyteptc hlpavskvlp afrespsgrl
     1261 mrqdpvvhls pnkqghsdsh ysshsssntl ssnassahsd ekwydgdrte selnsynylq
     1321 gtsadsgidt tsygpshgst aslgaatssp rsgpgkekva plwhsssevi smadrtlete
     1381 shgldrktes slsldihsks qagstpltre nstfsindaa shtstmssrh saspvvftsa
     1441 rsspkeelhp aapsqlapsf ssssssssgp rsfyprqgat skyligwkkp egtinsvgfm
     1501 dtrkrhqsdg neiahtrlra strdlraspk ptskstieed lkklidlesp tpesqksfkf
     1561 halsspqspf pstptsrral hrtlsdesiy nsqrehffts raslldqalp ndvlfsstyp
     1621 slpkslplrr psytlgmksl hgefsasdss ltdiqetrrq pmpdpglmpl pdtaadldws
     1681 nlvdaakaye vqrasffaas denhrplsaa snsdqledqa laqmkpysss kdssptlask
     1741 vdqlegmlkm lredlkkeke dkahlqaevq hlrednlrlq eesqnasdkl kkftewvfnt
     1801 idms
//
LOCUS       XP_024305297            1804 aa            linear   PRI 05-AUG-2025
DEFINITION  signal-induced proliferation-associated 1-like protein 1 isoform X1
            [Homo sapiens].
ACCESSION   XP_024305297
VERSION     XP_024305297.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449529.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1804
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1804
                     /product="signal-induced proliferation-associated 1-like
                     protein 1 isoform X1"
                     /calculated_mol_wt=199898
     Region          629..809
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     Region          953..1025
                     /region_name="PDZ_SIPA1-like"
                     /note="PDZ domain of signal-induced
                     proliferation-associated protein 1 (SIPA1), and related
                     domains; cd06745"
                     /db_xref="CDD:467227"
     Site            order(963..969,975,978,1007,1011,1014..1015)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467227"
     Region          1504..1749
                     /region_name="SPAR_C"
                     /note="C-terminal domain of SPAR protein; pfam11881"
                     /db_xref="CDD:463383"
     Region          1737..1792
                     /region_name="ZapB"
                     /note="Cell division protein ZapB; pfam06005"
                     /db_xref="CDD:428718"
     CDS             1..1804
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /coded_by="XM_024449529.2:606..6020"
                     /db_xref="GeneID:26037"
                     /db_xref="HGNC:HGNC:20284"
                     /db_xref="MIM:617504"
ORIGIN      
        1 mtslkrsqte rplatdrasv vgtdgtpkvh tddfymrrfr sqngslgssv mapvgpprse
       61 gshhitstpg vpkmgvrari adwpprkeni kessrssqei etsscldsls sksspvsqgs
      121 svslnsndsa mlksiqntlk nktrpsenmd srflmpeayp ssprkalrri rqrsnsditi
      181 seldvdsfde cisptyktgp slhreygsts sidkqgtsge sffdllkgyk ddksdrgptp
      241 tklsdflitg ggkgsgfsld vidgpisqre nlrlfkerek plkrrskset gdssifrklr
      301 nakgeelgks sdlednrsed svrpwtcpkc fahydvqsil fdlneaimnr hnvikrrntt
      361 tgasaaavas lvsgplshsa sfsspmgste dlnskgslsm dqgddksnel vmscpyfrne
      421 iggegerkis lsksnsgsfs gcesasfest lsshctnagv avlevpkenl vlhldrvkry
      481 ivehvdlgay yyrkffyqke hwnyfgaden lgpvavsirr ekpdemkeng spynyriifr
      541 tselmtlrgs vledaipsta khstarglpl kevlehvvpe lnvqclrlaf ntpkvteqlm
      601 kldeqglnyq qkvgimycka gqsteeemyn nesagpafee flqllgervr lkgfekyraq
      661 ldtktdstgt hslyttykdy eimfhvstml pytpnnkqql lrkrhigndi vtivfqepga
      721 qpfspknirs hfqhvfvivr vhnpcsdsvc ysvavtrsrd vpsfgppipk gvtfpksnvf
      781 rdfllakvin aenaahksek framatrtrq eylkdlaekn vtntpidpsg kfpfislask
      841 kkekskpypg aelssmgaiv wavraedynk ameldcllgi snefivlieq etksvvfncs
      901 crdvigwtst dtslkifyer gecvsvgsfi nieeikeivk rlqfvskgce svemtlrrng
      961 lgqlgfhvny egivadvepy gyawqaglrq gsrlveickv avatlsheqm idllrtsvtv
     1021 kvviipphdd ctprrscset yrmpvmeykm negvsyefkf pfrnnnkwqr naskgphspq
     1081 vpsqvqspmt srlnagkgdg kmppperaan iprsissdgr plerrlspgs diyvtvssma
     1141 larsqcrnsp snlssssdtg svggtyrqks mpegfgvsrr spasidrqnt qsdiggsgks
     1201 tpswqrseds iadqmaysyr gpqdfnsfvl eqheyteptc hlpavskvlp afrespsgrl
     1261 mrqdpvvhls pnkqghsdsh ysshsssntl ssnassahsd ekwydgdrte selnsynylq
     1321 gtsadsgidt tsygpshgst aslgaatssp rsgpgkekva plwhsssevi smadrtlete
     1381 shgldrktes slsldihsks qagstpltre nstfsindaa shtstmssrh saspvvftsa
     1441 rsspkeelhp aapsqlapsf ssssssssgp rsfyprqgat skyligwkkp egtinsvgfm
     1501 dtrkrhqsdg neiahtrlra strdlraspk ptskstieed lkklidlesp tpesqksfkf
     1561 halsspqspf pstptsrral hrtlsdesiy nsqrehffts raslldqalp ndvlfsstyp
     1621 slpkslplrr psytlgmksl hgefsasdss ltdiqetrrq pmpdpglmpl pdtaadldws
     1681 nlvdaakaye vqrasffaas denhrplsaa snsdqledqa laqmkpysss kdssptlask
     1741 vdqlegmlkm lredlkkeke dkahlqaevq hlrednlrlq eesqnasdkl kkftewvfnt
     1801 idms
//
LOCUS       XP_047287185            1804 aa            linear   PRI 05-AUG-2025
DEFINITION  signal-induced proliferation-associated 1-like protein 1 isoform X1
            [Homo sapiens].
ACCESSION   XP_047287185
VERSION     XP_047287185.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431229.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1804
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1804
                     /product="signal-induced proliferation-associated 1-like
                     protein 1 isoform X1"
                     /calculated_mol_wt=199898
     Region          629..809
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     Region          953..1025
                     /region_name="PDZ_SIPA1-like"
                     /note="PDZ domain of signal-induced
                     proliferation-associated protein 1 (SIPA1), and related
                     domains; cd06745"
                     /db_xref="CDD:467227"
     Site            order(963..969,975,978,1007,1011,1014..1015)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467227"
     Region          1504..1749
                     /region_name="SPAR_C"
                     /note="C-terminal domain of SPAR protein; pfam11881"
                     /db_xref="CDD:463383"
     Region          1737..1792
                     /region_name="ZapB"
                     /note="Cell division protein ZapB; pfam06005"
                     /db_xref="CDD:428718"
     CDS             1..1804
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /coded_by="XM_047431229.1:1224..6638"
                     /db_xref="GeneID:26037"
                     /db_xref="HGNC:HGNC:20284"
                     /db_xref="MIM:617504"
ORIGIN      
        1 mtslkrsqte rplatdrasv vgtdgtpkvh tddfymrrfr sqngslgssv mapvgpprse
       61 gshhitstpg vpkmgvrari adwpprkeni kessrssqei etsscldsls sksspvsqgs
      121 svslnsndsa mlksiqntlk nktrpsenmd srflmpeayp ssprkalrri rqrsnsditi
      181 seldvdsfde cisptyktgp slhreygsts sidkqgtsge sffdllkgyk ddksdrgptp
      241 tklsdflitg ggkgsgfsld vidgpisqre nlrlfkerek plkrrskset gdssifrklr
      301 nakgeelgks sdlednrsed svrpwtcpkc fahydvqsil fdlneaimnr hnvikrrntt
      361 tgasaaavas lvsgplshsa sfsspmgste dlnskgslsm dqgddksnel vmscpyfrne
      421 iggegerkis lsksnsgsfs gcesasfest lsshctnagv avlevpkenl vlhldrvkry
      481 ivehvdlgay yyrkffyqke hwnyfgaden lgpvavsirr ekpdemkeng spynyriifr
      541 tselmtlrgs vledaipsta khstarglpl kevlehvvpe lnvqclrlaf ntpkvteqlm
      601 kldeqglnyq qkvgimycka gqsteeemyn nesagpafee flqllgervr lkgfekyraq
      661 ldtktdstgt hslyttykdy eimfhvstml pytpnnkqql lrkrhigndi vtivfqepga
      721 qpfspknirs hfqhvfvivr vhnpcsdsvc ysvavtrsrd vpsfgppipk gvtfpksnvf
      781 rdfllakvin aenaahksek framatrtrq eylkdlaekn vtntpidpsg kfpfislask
      841 kkekskpypg aelssmgaiv wavraedynk ameldcllgi snefivlieq etksvvfncs
      901 crdvigwtst dtslkifyer gecvsvgsfi nieeikeivk rlqfvskgce svemtlrrng
      961 lgqlgfhvny egivadvepy gyawqaglrq gsrlveickv avatlsheqm idllrtsvtv
     1021 kvviipphdd ctprrscset yrmpvmeykm negvsyefkf pfrnnnkwqr naskgphspq
     1081 vpsqvqspmt srlnagkgdg kmppperaan iprsissdgr plerrlspgs diyvtvssma
     1141 larsqcrnsp snlssssdtg svggtyrqks mpegfgvsrr spasidrqnt qsdiggsgks
     1201 tpswqrseds iadqmaysyr gpqdfnsfvl eqheyteptc hlpavskvlp afrespsgrl
     1261 mrqdpvvhls pnkqghsdsh ysshsssntl ssnassahsd ekwydgdrte selnsynylq
     1321 gtsadsgidt tsygpshgst aslgaatssp rsgpgkekva plwhsssevi smadrtlete
     1381 shgldrktes slsldihsks qagstpltre nstfsindaa shtstmssrh saspvvftsa
     1441 rsspkeelhp aapsqlapsf ssssssssgp rsfyprqgat skyligwkkp egtinsvgfm
     1501 dtrkrhqsdg neiahtrlra strdlraspk ptskstieed lkklidlesp tpesqksfkf
     1561 halsspqspf pstptsrral hrtlsdesiy nsqrehffts raslldqalp ndvlfsstyp
     1621 slpkslplrr psytlgmksl hgefsasdss ltdiqetrrq pmpdpglmpl pdtaadldws
     1681 nlvdaakaye vqrasffaas denhrplsaa snsdqledqa laqmkpysss kdssptlask
     1741 vdqlegmlkm lredlkkeke dkahlqaevq hlrednlrlq eesqnasdkl kkftewvfnt
     1801 idms
//
LOCUS       XP_011534934            1804 aa            linear   PRI 05-AUG-2025
DEFINITION  signal-induced proliferation-associated 1-like protein 1 isoform X1
            [Homo sapiens].
ACCESSION   XP_011534934
VERSION     XP_011534934.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536632.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1804
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1804
                     /product="signal-induced proliferation-associated 1-like
                     protein 1 isoform X1"
                     /calculated_mol_wt=199898
     Region          629..809
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     Region          953..1025
                     /region_name="PDZ_SIPA1-like"
                     /note="PDZ domain of signal-induced
                     proliferation-associated protein 1 (SIPA1), and related
                     domains; cd06745"
                     /db_xref="CDD:467227"
     Site            order(963..969,975,978,1007,1011,1014..1015)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467227"
     Region          1504..1749
                     /region_name="SPAR_C"
                     /note="C-terminal domain of SPAR protein; pfam11881"
                     /db_xref="CDD:463383"
     Region          1737..1792
                     /region_name="ZapB"
                     /note="Cell division protein ZapB; pfam06005"
                     /db_xref="CDD:428718"
     CDS             1..1804
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /coded_by="XM_011536632.2:942..6356"
                     /db_xref="GeneID:26037"
                     /db_xref="HGNC:HGNC:20284"
                     /db_xref="MIM:617504"
ORIGIN      
        1 mtslkrsqte rplatdrasv vgtdgtpkvh tddfymrrfr sqngslgssv mapvgpprse
       61 gshhitstpg vpkmgvrari adwpprkeni kessrssqei etsscldsls sksspvsqgs
      121 svslnsndsa mlksiqntlk nktrpsenmd srflmpeayp ssprkalrri rqrsnsditi
      181 seldvdsfde cisptyktgp slhreygsts sidkqgtsge sffdllkgyk ddksdrgptp
      241 tklsdflitg ggkgsgfsld vidgpisqre nlrlfkerek plkrrskset gdssifrklr
      301 nakgeelgks sdlednrsed svrpwtcpkc fahydvqsil fdlneaimnr hnvikrrntt
      361 tgasaaavas lvsgplshsa sfsspmgste dlnskgslsm dqgddksnel vmscpyfrne
      421 iggegerkis lsksnsgsfs gcesasfest lsshctnagv avlevpkenl vlhldrvkry
      481 ivehvdlgay yyrkffyqke hwnyfgaden lgpvavsirr ekpdemkeng spynyriifr
      541 tselmtlrgs vledaipsta khstarglpl kevlehvvpe lnvqclrlaf ntpkvteqlm
      601 kldeqglnyq qkvgimycka gqsteeemyn nesagpafee flqllgervr lkgfekyraq
      661 ldtktdstgt hslyttykdy eimfhvstml pytpnnkqql lrkrhigndi vtivfqepga
      721 qpfspknirs hfqhvfvivr vhnpcsdsvc ysvavtrsrd vpsfgppipk gvtfpksnvf
      781 rdfllakvin aenaahksek framatrtrq eylkdlaekn vtntpidpsg kfpfislask
      841 kkekskpypg aelssmgaiv wavraedynk ameldcllgi snefivlieq etksvvfncs
      901 crdvigwtst dtslkifyer gecvsvgsfi nieeikeivk rlqfvskgce svemtlrrng
      961 lgqlgfhvny egivadvepy gyawqaglrq gsrlveickv avatlsheqm idllrtsvtv
     1021 kvviipphdd ctprrscset yrmpvmeykm negvsyefkf pfrnnnkwqr naskgphspq
     1081 vpsqvqspmt srlnagkgdg kmppperaan iprsissdgr plerrlspgs diyvtvssma
     1141 larsqcrnsp snlssssdtg svggtyrqks mpegfgvsrr spasidrqnt qsdiggsgks
     1201 tpswqrseds iadqmaysyr gpqdfnsfvl eqheyteptc hlpavskvlp afrespsgrl
     1261 mrqdpvvhls pnkqghsdsh ysshsssntl ssnassahsd ekwydgdrte selnsynylq
     1321 gtsadsgidt tsygpshgst aslgaatssp rsgpgkekva plwhsssevi smadrtlete
     1381 shgldrktes slsldihsks qagstpltre nstfsindaa shtstmssrh saspvvftsa
     1441 rsspkeelhp aapsqlapsf ssssssssgp rsfyprqgat skyligwkkp egtinsvgfm
     1501 dtrkrhqsdg neiahtrlra strdlraspk ptskstieed lkklidlesp tpesqksfkf
     1561 halsspqspf pstptsrral hrtlsdesiy nsqrehffts raslldqalp ndvlfsstyp
     1621 slpkslplrr psytlgmksl hgefsasdss ltdiqetrrq pmpdpglmpl pdtaadldws
     1681 nlvdaakaye vqrasffaas denhrplsaa snsdqledqa laqmkpysss kdssptlask
     1741 vdqlegmlkm lredlkkeke dkahlqaevq hlrednlrlq eesqnasdkl kkftewvfnt
     1801 idms
//
LOCUS       XP_047287187            1804 aa            linear   PRI 05-AUG-2025
DEFINITION  signal-induced proliferation-associated 1-like protein 1 isoform X1
            [Homo sapiens].
ACCESSION   XP_047287187
VERSION     XP_047287187.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431231.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1804
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1804
                     /product="signal-induced proliferation-associated 1-like
                     protein 1 isoform X1"
                     /calculated_mol_wt=199898
     Region          629..809
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     Region          953..1025
                     /region_name="PDZ_SIPA1-like"
                     /note="PDZ domain of signal-induced
                     proliferation-associated protein 1 (SIPA1), and related
                     domains; cd06745"
                     /db_xref="CDD:467227"
     Site            order(963..969,975,978,1007,1011,1014..1015)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467227"
     Region          1504..1749
                     /region_name="SPAR_C"
                     /note="C-terminal domain of SPAR protein; pfam11881"
                     /db_xref="CDD:463383"
     Region          1737..1792
                     /region_name="ZapB"
                     /note="Cell division protein ZapB; pfam06005"
                     /db_xref="CDD:428718"
     CDS             1..1804
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /coded_by="XM_047431231.1:578..5992"
                     /db_xref="GeneID:26037"
                     /db_xref="HGNC:HGNC:20284"
                     /db_xref="MIM:617504"
ORIGIN      
        1 mtslkrsqte rplatdrasv vgtdgtpkvh tddfymrrfr sqngslgssv mapvgpprse
       61 gshhitstpg vpkmgvrari adwpprkeni kessrssqei etsscldsls sksspvsqgs
      121 svslnsndsa mlksiqntlk nktrpsenmd srflmpeayp ssprkalrri rqrsnsditi
      181 seldvdsfde cisptyktgp slhreygsts sidkqgtsge sffdllkgyk ddksdrgptp
      241 tklsdflitg ggkgsgfsld vidgpisqre nlrlfkerek plkrrskset gdssifrklr
      301 nakgeelgks sdlednrsed svrpwtcpkc fahydvqsil fdlneaimnr hnvikrrntt
      361 tgasaaavas lvsgplshsa sfsspmgste dlnskgslsm dqgddksnel vmscpyfrne
      421 iggegerkis lsksnsgsfs gcesasfest lsshctnagv avlevpkenl vlhldrvkry
      481 ivehvdlgay yyrkffyqke hwnyfgaden lgpvavsirr ekpdemkeng spynyriifr
      541 tselmtlrgs vledaipsta khstarglpl kevlehvvpe lnvqclrlaf ntpkvteqlm
      601 kldeqglnyq qkvgimycka gqsteeemyn nesagpafee flqllgervr lkgfekyraq
      661 ldtktdstgt hslyttykdy eimfhvstml pytpnnkqql lrkrhigndi vtivfqepga
      721 qpfspknirs hfqhvfvivr vhnpcsdsvc ysvavtrsrd vpsfgppipk gvtfpksnvf
      781 rdfllakvin aenaahksek framatrtrq eylkdlaekn vtntpidpsg kfpfislask
      841 kkekskpypg aelssmgaiv wavraedynk ameldcllgi snefivlieq etksvvfncs
      901 crdvigwtst dtslkifyer gecvsvgsfi nieeikeivk rlqfvskgce svemtlrrng
      961 lgqlgfhvny egivadvepy gyawqaglrq gsrlveickv avatlsheqm idllrtsvtv
     1021 kvviipphdd ctprrscset yrmpvmeykm negvsyefkf pfrnnnkwqr naskgphspq
     1081 vpsqvqspmt srlnagkgdg kmppperaan iprsissdgr plerrlspgs diyvtvssma
     1141 larsqcrnsp snlssssdtg svggtyrqks mpegfgvsrr spasidrqnt qsdiggsgks
     1201 tpswqrseds iadqmaysyr gpqdfnsfvl eqheyteptc hlpavskvlp afrespsgrl
     1261 mrqdpvvhls pnkqghsdsh ysshsssntl ssnassahsd ekwydgdrte selnsynylq
     1321 gtsadsgidt tsygpshgst aslgaatssp rsgpgkekva plwhsssevi smadrtlete
     1381 shgldrktes slsldihsks qagstpltre nstfsindaa shtstmssrh saspvvftsa
     1441 rsspkeelhp aapsqlapsf ssssssssgp rsfyprqgat skyligwkkp egtinsvgfm
     1501 dtrkrhqsdg neiahtrlra strdlraspk ptskstieed lkklidlesp tpesqksfkf
     1561 halsspqspf pstptsrral hrtlsdesiy nsqrehffts raslldqalp ndvlfsstyp
     1621 slpkslplrr psytlgmksl hgefsasdss ltdiqetrrq pmpdpglmpl pdtaadldws
     1681 nlvdaakaye vqrasffaas denhrplsaa snsdqledqa laqmkpysss kdssptlask
     1741 vdqlegmlkm lredlkkeke dkahlqaevq hlrednlrlq eesqnasdkl kkftewvfnt
     1801 idms
//
LOCUS       XP_047287188            1803 aa            linear   PRI 05-AUG-2025
DEFINITION  signal-induced proliferation-associated 1-like protein 1 isoform X2
            [Homo sapiens].
ACCESSION   XP_047287188
VERSION     XP_047287188.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431232.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1803
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1803
                     /product="signal-induced proliferation-associated 1-like
                     protein 1 isoform X2"
                     /calculated_mol_wt=199811
     Region          629..809
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     Region          953..1025
                     /region_name="PDZ_SIPA1-like"
                     /note="PDZ domain of signal-induced
                     proliferation-associated protein 1 (SIPA1), and related
                     domains; cd06745"
                     /db_xref="CDD:467227"
     Site            order(963..969,975,978,1007,1011,1014..1015)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467227"
     Region          1504..1748
                     /region_name="SPAR_C"
                     /note="C-terminal domain of SPAR protein; pfam11881"
                     /db_xref="CDD:463383"
     Region          1736..1791
                     /region_name="ZapB"
                     /note="Cell division protein ZapB; pfam06005"
                     /db_xref="CDD:428718"
     CDS             1..1803
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /coded_by="XM_047431232.1:2252..7663"
                     /db_xref="GeneID:26037"
                     /db_xref="HGNC:HGNC:20284"
                     /db_xref="MIM:617504"
ORIGIN      
        1 mtslkrsqte rplatdrasv vgtdgtpkvh tddfymrrfr sqngslgssv mapvgpprse
       61 gshhitstpg vpkmgvrari adwpprkeni kessrssqei etsscldsls sksspvsqgs
      121 svslnsndsa mlksiqntlk nktrpsenmd srflmpeayp ssprkalrri rqrsnsditi
      181 seldvdsfde cisptyktgp slhreygsts sidkqgtsge sffdllkgyk ddksdrgptp
      241 tklsdflitg ggkgsgfsld vidgpisqre nlrlfkerek plkrrskset gdssifrklr
      301 nakgeelgks sdlednrsed svrpwtcpkc fahydvqsil fdlneaimnr hnvikrrntt
      361 tgasaaavas lvsgplshsa sfsspmgste dlnskgslsm dqgddksnel vmscpyfrne
      421 iggegerkis lsksnsgsfs gcesasfest lsshctnagv avlevpkenl vlhldrvkry
      481 ivehvdlgay yyrkffyqke hwnyfgaden lgpvavsirr ekpdemkeng spynyriifr
      541 tselmtlrgs vledaipsta khstarglpl kevlehvvpe lnvqclrlaf ntpkvteqlm
      601 kldeqglnyq qkvgimycka gqsteeemyn nesagpafee flqllgervr lkgfekyraq
      661 ldtktdstgt hslyttykdy eimfhvstml pytpnnkqql lrkrhigndi vtivfqepga
      721 qpfspknirs hfqhvfvivr vhnpcsdsvc ysvavtrsrd vpsfgppipk gvtfpksnvf
      781 rdfllakvin aenaahksek framatrtrq eylkdlaekn vtntpidpsg kfpfislask
      841 kkekskpypg aelssmgaiv wavraedynk ameldcllgi snefivlieq etksvvfncs
      901 crdvigwtst dtslkifyer gecvsvgsfi nieeikeivk rlqfvskgce svemtlrrng
      961 lgqlgfhvny egivadvepy gyawqaglrq gsrlveickv avatlsheqm idllrtsvtv
     1021 kvviipphdd ctprrscset yrmpvmeykm negvsyefkf pfrnnnkwqr naskgphspq
     1081 vpsqvqspmt srlnagkgdg kmppperaan iprsissdgr plerrlspgs diyvtvssma
     1141 larsqcrnsp snlssssdtg svggtyrqks mpegfgvsrr spasidrqnt qsdiggsgks
     1201 tpswqrseds iadqmaysyr gpqdfnsfvl eqheyteptc hlpavskvlp afrespsgrl
     1261 mrqdpvvhls pnkqghsdsh ysshsssntl ssnassahsd ekwydgdrte selnsynylq
     1321 gtsadsgidt tsygpshgst aslgaatssp rsgpgkekva plwhsssevi smadrtlete
     1381 shgldrktes slsldihsks qagstpltre nstfsindaa shtstmssrh saspvvftsa
     1441 rsspkeelhp aapsqlapsf ssssssssgp rsfyprqgat skyligwkkp egtinsvgfm
     1501 dtrkrhqsdg neiahtrlra strdlraspk ptskstieed lkklidlesp tpesqksfkf
     1561 halsspqspf pstptsrral hrtlsdesiy nsqrehffts raslldqalp ndvlfsstyp
     1621 slpkslplrr psytlgmksl hgefsasdss ltdiqetrrq pmpdpglmpl pdtaadldws
     1681 nlvdaakaye vqrasffaas denhrplsaa snsdqledqa laqmkpyssk dssptlaskv
     1741 dqlegmlkml redlkkeked kahlqaevqh lrednlrlqe esqnasdklk kftewvfnti
     1801 dms
//
LOCUS       XP_016876674            1803 aa            linear   PRI 05-AUG-2025
DEFINITION  signal-induced proliferation-associated 1-like protein 1 isoform X2
            [Homo sapiens].
ACCESSION   XP_016876674
VERSION     XP_016876674.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021185.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1803
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1803
                     /product="signal-induced proliferation-associated 1-like
                     protein 1 isoform X2"
                     /calculated_mol_wt=199811
     Region          629..809
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     Region          953..1025
                     /region_name="PDZ_SIPA1-like"
                     /note="PDZ domain of signal-induced
                     proliferation-associated protein 1 (SIPA1), and related
                     domains; cd06745"
                     /db_xref="CDD:467227"
     Site            order(963..969,975,978,1007,1011,1014..1015)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467227"
     Region          1504..1748
                     /region_name="SPAR_C"
                     /note="C-terminal domain of SPAR protein; pfam11881"
                     /db_xref="CDD:463383"
     Region          1736..1791
                     /region_name="ZapB"
                     /note="Cell division protein ZapB; pfam06005"
                     /db_xref="CDD:428718"
     CDS             1..1803
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /coded_by="XM_017021185.2:934..6345"
                     /db_xref="GeneID:26037"
                     /db_xref="HGNC:HGNC:20284"
                     /db_xref="MIM:617504"
ORIGIN      
        1 mtslkrsqte rplatdrasv vgtdgtpkvh tddfymrrfr sqngslgssv mapvgpprse
       61 gshhitstpg vpkmgvrari adwpprkeni kessrssqei etsscldsls sksspvsqgs
      121 svslnsndsa mlksiqntlk nktrpsenmd srflmpeayp ssprkalrri rqrsnsditi
      181 seldvdsfde cisptyktgp slhreygsts sidkqgtsge sffdllkgyk ddksdrgptp
      241 tklsdflitg ggkgsgfsld vidgpisqre nlrlfkerek plkrrskset gdssifrklr
      301 nakgeelgks sdlednrsed svrpwtcpkc fahydvqsil fdlneaimnr hnvikrrntt
      361 tgasaaavas lvsgplshsa sfsspmgste dlnskgslsm dqgddksnel vmscpyfrne
      421 iggegerkis lsksnsgsfs gcesasfest lsshctnagv avlevpkenl vlhldrvkry
      481 ivehvdlgay yyrkffyqke hwnyfgaden lgpvavsirr ekpdemkeng spynyriifr
      541 tselmtlrgs vledaipsta khstarglpl kevlehvvpe lnvqclrlaf ntpkvteqlm
      601 kldeqglnyq qkvgimycka gqsteeemyn nesagpafee flqllgervr lkgfekyraq
      661 ldtktdstgt hslyttykdy eimfhvstml pytpnnkqql lrkrhigndi vtivfqepga
      721 qpfspknirs hfqhvfvivr vhnpcsdsvc ysvavtrsrd vpsfgppipk gvtfpksnvf
      781 rdfllakvin aenaahksek framatrtrq eylkdlaekn vtntpidpsg kfpfislask
      841 kkekskpypg aelssmgaiv wavraedynk ameldcllgi snefivlieq etksvvfncs
      901 crdvigwtst dtslkifyer gecvsvgsfi nieeikeivk rlqfvskgce svemtlrrng
      961 lgqlgfhvny egivadvepy gyawqaglrq gsrlveickv avatlsheqm idllrtsvtv
     1021 kvviipphdd ctprrscset yrmpvmeykm negvsyefkf pfrnnnkwqr naskgphspq
     1081 vpsqvqspmt srlnagkgdg kmppperaan iprsissdgr plerrlspgs diyvtvssma
     1141 larsqcrnsp snlssssdtg svggtyrqks mpegfgvsrr spasidrqnt qsdiggsgks
     1201 tpswqrseds iadqmaysyr gpqdfnsfvl eqheyteptc hlpavskvlp afrespsgrl
     1261 mrqdpvvhls pnkqghsdsh ysshsssntl ssnassahsd ekwydgdrte selnsynylq
     1321 gtsadsgidt tsygpshgst aslgaatssp rsgpgkekva plwhsssevi smadrtlete
     1381 shgldrktes slsldihsks qagstpltre nstfsindaa shtstmssrh saspvvftsa
     1441 rsspkeelhp aapsqlapsf ssssssssgp rsfyprqgat skyligwkkp egtinsvgfm
     1501 dtrkrhqsdg neiahtrlra strdlraspk ptskstieed lkklidlesp tpesqksfkf
     1561 halsspqspf pstptsrral hrtlsdesiy nsqrehffts raslldqalp ndvlfsstyp
     1621 slpkslplrr psytlgmksl hgefsasdss ltdiqetrrq pmpdpglmpl pdtaadldws
     1681 nlvdaakaye vqrasffaas denhrplsaa snsdqledqa laqmkpyssk dssptlaskv
     1741 dqlegmlkml redlkkeked kahlqaevqh lrednlrlqe esqnasdklk kftewvfnti
     1801 dms
//
LOCUS       XP_047287189            1783 aa            linear   PRI 05-AUG-2025
DEFINITION  signal-induced proliferation-associated 1-like protein 1 isoform X3
            [Homo sapiens].
ACCESSION   XP_047287189
VERSION     XP_047287189.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431233.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1783
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1783
                     /product="signal-induced proliferation-associated 1-like
                     protein 1 isoform X3"
                     /calculated_mol_wt=197365
     Region          629..809
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     Region          953..1025
                     /region_name="PDZ_SIPA1-like"
                     /note="PDZ domain of signal-induced
                     proliferation-associated protein 1 (SIPA1), and related
                     domains; cd06745"
                     /db_xref="CDD:467227"
     Site            order(963..969,975,978,1007,1011,1014..1015)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467227"
     Region          1483..1728
                     /region_name="SPAR_C"
                     /note="C-terminal domain of SPAR protein; pfam11881"
                     /db_xref="CDD:463383"
     Region          1716..1771
                     /region_name="ZapB"
                     /note="Cell division protein ZapB; pfam06005"
                     /db_xref="CDD:428718"
     CDS             1..1783
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /coded_by="XM_047431233.1:2252..7603"
                     /db_xref="GeneID:26037"
                     /db_xref="HGNC:HGNC:20284"
                     /db_xref="MIM:617504"
ORIGIN      
        1 mtslkrsqte rplatdrasv vgtdgtpkvh tddfymrrfr sqngslgssv mapvgpprse
       61 gshhitstpg vpkmgvrari adwpprkeni kessrssqei etsscldsls sksspvsqgs
      121 svslnsndsa mlksiqntlk nktrpsenmd srflmpeayp ssprkalrri rqrsnsditi
      181 seldvdsfde cisptyktgp slhreygsts sidkqgtsge sffdllkgyk ddksdrgptp
      241 tklsdflitg ggkgsgfsld vidgpisqre nlrlfkerek plkrrskset gdssifrklr
      301 nakgeelgks sdlednrsed svrpwtcpkc fahydvqsil fdlneaimnr hnvikrrntt
      361 tgasaaavas lvsgplshsa sfsspmgste dlnskgslsm dqgddksnel vmscpyfrne
      421 iggegerkis lsksnsgsfs gcesasfest lsshctnagv avlevpkenl vlhldrvkry
      481 ivehvdlgay yyrkffyqke hwnyfgaden lgpvavsirr ekpdemkeng spynyriifr
      541 tselmtlrgs vledaipsta khstarglpl kevlehvvpe lnvqclrlaf ntpkvteqlm
      601 kldeqglnyq qkvgimycka gqsteeemyn nesagpafee flqllgervr lkgfekyraq
      661 ldtktdstgt hslyttykdy eimfhvstml pytpnnkqql lrkrhigndi vtivfqepga
      721 qpfspknirs hfqhvfvivr vhnpcsdsvc ysvavtrsrd vpsfgppipk gvtfpksnvf
      781 rdfllakvin aenaahksek framatrtrq eylkdlaekn vtntpidpsg kfpfislask
      841 kkekskpypg aelssmgaiv wavraedynk ameldcllgi snefivlieq etksvvfncs
      901 crdvigwtst dtslkifyer gecvsvgsfi nieeikeivk rlqfvskgce svemtlrrng
      961 lgqlgfhvny egivadvepy gyawqaglrq gsrlveickv avatlsheqm idllrtsvtv
     1021 kvviipphdd ctprrscset yrmpvmeykm negvsyefkf pfrnnnkwqr naskgphspq
     1081 vpsqvqspmt srlnagkgdg kmppperaan iprsissdgr plerrlspgs diyvtvssma
     1141 larsqcrnsp snlssssdtg svggtyrqks mpegfgvsrr spasidrqnt qsdiggsgks
     1201 tpswqrseds iadqmeptch lpavskvlpa frespsgrlm rqdpvvhlsp nkqghsdshy
     1261 sshsssntls snassahsde kwydgdrtes elnsynylqg tsadsgidtt sygpshgsta
     1321 slgaatsspr sgpgkekvap lwhsssevis madrtletes hgldrktess lsldihsksq
     1381 agstpltren stfsindaas htstmssrhs aspvvftsar sspkeelhpa apsqlapsfs
     1441 sssssssgpr sfyprqgats kyligwkkpe gtinsvgfmd trkrhqsdgn eiahtrlras
     1501 trdlraspkp tskstieedl kklidlespt pesqksfkfh alsspqspfp stptsrralh
     1561 rtlsdesiyn sqrehfftsr aslldqalpn dvlfsstyps lpkslplrrp sytlgmkslh
     1621 gefsasdssl tdiqetrrqp mpdpglmplp dtaadldwsn lvdaakayev qrasffaasd
     1681 enhrplsaas nsdqledqal aqmkpysssk dssptlaskv dqlegmlkml redlkkeked
     1741 kahlqaevqh lrednlrlqe esqnasdklk kftewvfnti dms
//
LOCUS       XP_047287190            1782 aa            linear   PRI 05-AUG-2025
DEFINITION  signal-induced proliferation-associated 1-like protein 1 isoform X4
            [Homo sapiens].
ACCESSION   XP_047287190
VERSION     XP_047287190.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431234.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1782
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1782
                     /product="signal-induced proliferation-associated 1-like
                     protein 1 isoform X4"
                     /calculated_mol_wt=197278
     Region          629..809
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     Region          953..1025
                     /region_name="PDZ_SIPA1-like"
                     /note="PDZ domain of signal-induced
                     proliferation-associated protein 1 (SIPA1), and related
                     domains; cd06745"
                     /db_xref="CDD:467227"
     Site            order(963..969,975,978,1007,1011,1014..1015)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467227"
     Region          1483..1727
                     /region_name="SPAR_C"
                     /note="C-terminal domain of SPAR protein; pfam11881"
                     /db_xref="CDD:463383"
     Region          1715..1770
                     /region_name="ZapB"
                     /note="Cell division protein ZapB; pfam06005"
                     /db_xref="CDD:428718"
     CDS             1..1782
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /coded_by="XM_047431234.1:2252..7600"
                     /db_xref="GeneID:26037"
                     /db_xref="HGNC:HGNC:20284"
                     /db_xref="MIM:617504"
ORIGIN      
        1 mtslkrsqte rplatdrasv vgtdgtpkvh tddfymrrfr sqngslgssv mapvgpprse
       61 gshhitstpg vpkmgvrari adwpprkeni kessrssqei etsscldsls sksspvsqgs
      121 svslnsndsa mlksiqntlk nktrpsenmd srflmpeayp ssprkalrri rqrsnsditi
      181 seldvdsfde cisptyktgp slhreygsts sidkqgtsge sffdllkgyk ddksdrgptp
      241 tklsdflitg ggkgsgfsld vidgpisqre nlrlfkerek plkrrskset gdssifrklr
      301 nakgeelgks sdlednrsed svrpwtcpkc fahydvqsil fdlneaimnr hnvikrrntt
      361 tgasaaavas lvsgplshsa sfsspmgste dlnskgslsm dqgddksnel vmscpyfrne
      421 iggegerkis lsksnsgsfs gcesasfest lsshctnagv avlevpkenl vlhldrvkry
      481 ivehvdlgay yyrkffyqke hwnyfgaden lgpvavsirr ekpdemkeng spynyriifr
      541 tselmtlrgs vledaipsta khstarglpl kevlehvvpe lnvqclrlaf ntpkvteqlm
      601 kldeqglnyq qkvgimycka gqsteeemyn nesagpafee flqllgervr lkgfekyraq
      661 ldtktdstgt hslyttykdy eimfhvstml pytpnnkqql lrkrhigndi vtivfqepga
      721 qpfspknirs hfqhvfvivr vhnpcsdsvc ysvavtrsrd vpsfgppipk gvtfpksnvf
      781 rdfllakvin aenaahksek framatrtrq eylkdlaekn vtntpidpsg kfpfislask
      841 kkekskpypg aelssmgaiv wavraedynk ameldcllgi snefivlieq etksvvfncs
      901 crdvigwtst dtslkifyer gecvsvgsfi nieeikeivk rlqfvskgce svemtlrrng
      961 lgqlgfhvny egivadvepy gyawqaglrq gsrlveickv avatlsheqm idllrtsvtv
     1021 kvviipphdd ctprrscset yrmpvmeykm negvsyefkf pfrnnnkwqr naskgphspq
     1081 vpsqvqspmt srlnagkgdg kmppperaan iprsissdgr plerrlspgs diyvtvssma
     1141 larsqcrnsp snlssssdtg svggtyrqks mpegfgvsrr spasidrqnt qsdiggsgks
     1201 tpswqrseds iadqmeptch lpavskvlpa frespsgrlm rqdpvvhlsp nkqghsdshy
     1261 sshsssntls snassahsde kwydgdrtes elnsynylqg tsadsgidtt sygpshgsta
     1321 slgaatsspr sgpgkekvap lwhsssevis madrtletes hgldrktess lsldihsksq
     1381 agstpltren stfsindaas htstmssrhs aspvvftsar sspkeelhpa apsqlapsfs
     1441 sssssssgpr sfyprqgats kyligwkkpe gtinsvgfmd trkrhqsdgn eiahtrlras
     1501 trdlraspkp tskstieedl kklidlespt pesqksfkfh alsspqspfp stptsrralh
     1561 rtlsdesiyn sqrehfftsr aslldqalpn dvlfsstyps lpkslplrrp sytlgmkslh
     1621 gefsasdssl tdiqetrrqp mpdpglmplp dtaadldwsn lvdaakayev qrasffaasd
     1681 enhrplsaas nsdqledqal aqmkpysskd ssptlaskvd qlegmlkmlr edlkkekedk
     1741 ahlqaevqhl rednlrlqee sqnasdklkk ftewvfntid ms
//
LOCUS       XP_047287191            1755 aa            linear   PRI 05-AUG-2025
DEFINITION  signal-induced proliferation-associated 1-like protein 1 isoform X5
            [Homo sapiens].
ACCESSION   XP_047287191
VERSION     XP_047287191.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431235.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1755
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1755
                     /product="signal-induced proliferation-associated 1-like
                     protein 1 isoform X5"
                     /calculated_mol_wt=194862
     Region          629..809
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     Region          953..1025
                     /region_name="PDZ_SIPA1-like"
                     /note="PDZ domain of signal-induced
                     proliferation-associated protein 1 (SIPA1), and related
                     domains; cd06745"
                     /db_xref="CDD:467227"
     Site            order(963..969,975,978,1007,1011,1014..1015)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467227"
     Region          1455..1700
                     /region_name="SPAR_C"
                     /note="C-terminal domain of SPAR protein; pfam11881"
                     /db_xref="CDD:463383"
     Region          1688..1743
                     /region_name="ZapB"
                     /note="Cell division protein ZapB; pfam06005"
                     /db_xref="CDD:428718"
     CDS             1..1755
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /coded_by="XM_047431235.1:2252..7519"
                     /db_xref="GeneID:26037"
                     /db_xref="HGNC:HGNC:20284"
                     /db_xref="MIM:617504"
ORIGIN      
        1 mtslkrsqte rplatdrasv vgtdgtpkvh tddfymrrfr sqngslgssv mapvgpprse
       61 gshhitstpg vpkmgvrari adwpprkeni kessrssqei etsscldsls sksspvsqgs
      121 svslnsndsa mlksiqntlk nktrpsenmd srflmpeayp ssprkalrri rqrsnsditi
      181 seldvdsfde cisptyktgp slhreygsts sidkqgtsge sffdllkgyk ddksdrgptp
      241 tklsdflitg ggkgsgfsld vidgpisqre nlrlfkerek plkrrskset gdssifrklr
      301 nakgeelgks sdlednrsed svrpwtcpkc fahydvqsil fdlneaimnr hnvikrrntt
      361 tgasaaavas lvsgplshsa sfsspmgste dlnskgslsm dqgddksnel vmscpyfrne
      421 iggegerkis lsksnsgsfs gcesasfest lsshctnagv avlevpkenl vlhldrvkry
      481 ivehvdlgay yyrkffyqke hwnyfgaden lgpvavsirr ekpdemkeng spynyriifr
      541 tselmtlrgs vledaipsta khstarglpl kevlehvvpe lnvqclrlaf ntpkvteqlm
      601 kldeqglnyq qkvgimycka gqsteeemyn nesagpafee flqllgervr lkgfekyraq
      661 ldtktdstgt hslyttykdy eimfhvstml pytpnnkqql lrkrhigndi vtivfqepga
      721 qpfspknirs hfqhvfvivr vhnpcsdsvc ysvavtrsrd vpsfgppipk gvtfpksnvf
      781 rdfllakvin aenaahksek framatrtrq eylkdlaekn vtntpidpsg kfpfislask
      841 kkekskpypg aelssmgaiv wavraedynk ameldcllgi snefivlieq etksvvfncs
      901 crdvigwtst dtslkifyer gecvsvgsfi nieeikeivk rlqfvskgce svemtlrrng
      961 lgqlgfhvny egivadvepy gyawqaglrq gsrlveickv avatlsheqm idllrtsvtv
     1021 kvviipphdd ctprrscset yrmpvmeykm negvsyefkf pfrnnnkwqr naskgphspq
     1081 vpsqvqspmt srlnagkgdg kmppperaan iprsissdgr plerrfgvsr rspasidrqn
     1141 tqsdiggsgk stpswqrsed siadqmaysy rgpqdfnsfv leqheytept chlpavskvl
     1201 pafrespsgr lmrqdpvvhl spnkqghsds hysshsssnt lssnassahs dekwydgdrt
     1261 eselnsynyl qgtsadsgid ttsygpshgs taslgaatss prsgpgkekv aplwhsssev
     1321 ismadrtlet eshgldrkte sslsldihsk sqagstpltr enstfsinda ashtstmssr
     1381 hsaspvvfts arsspkeelh paapsqlaps fssssssssg prsfyprqga tskyligwkk
     1441 pegtinsvgf mdtrkrhqsd gneiahtrlr astrdlrasp kptskstiee dlkklidles
     1501 ptpesqksfk fhalsspqsp fpstptsrra lhrtlsdesi ynsqrehfft sraslldqal
     1561 pndvlfssty pslpkslplr rpsytlgmks lhgefsasds sltdiqetrr qpmpdpglmp
     1621 lpdtaadldw snlvdaakay evqrasffaa sdenhrplsa asnsdqledq alaqmkpyss
     1681 skdssptlas kvdqlegmlk mlredlkkek edkahlqaev qhlrednlrl qeesqnasdk
     1741 lkkftewvfn tidms
//
LOCUS       XP_047287192            1734 aa            linear   PRI 05-AUG-2025
DEFINITION  signal-induced proliferation-associated 1-like protein 1 isoform X6
            [Homo sapiens].
ACCESSION   XP_047287192
VERSION     XP_047287192.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431236.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1734
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1734
                     /product="signal-induced proliferation-associated 1-like
                     protein 1 isoform X6"
                     /calculated_mol_wt=192328
     Region          629..809
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     Region          953..1025
                     /region_name="PDZ_SIPA1-like"
                     /note="PDZ domain of signal-induced
                     proliferation-associated protein 1 (SIPA1), and related
                     domains; cd06745"
                     /db_xref="CDD:467227"
     Site            order(963..969,975,978,1007,1011,1014..1015)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467227"
     Region          1434..1679
                     /region_name="SPAR_C"
                     /note="C-terminal domain of SPAR protein; pfam11881"
                     /db_xref="CDD:463383"
     Region          1667..1722
                     /region_name="ZapB"
                     /note="Cell division protein ZapB; pfam06005"
                     /db_xref="CDD:428718"
     CDS             1..1734
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /coded_by="XM_047431236.1:2252..7456"
                     /db_xref="GeneID:26037"
                     /db_xref="HGNC:HGNC:20284"
                     /db_xref="MIM:617504"
ORIGIN      
        1 mtslkrsqte rplatdrasv vgtdgtpkvh tddfymrrfr sqngslgssv mapvgpprse
       61 gshhitstpg vpkmgvrari adwpprkeni kessrssqei etsscldsls sksspvsqgs
      121 svslnsndsa mlksiqntlk nktrpsenmd srflmpeayp ssprkalrri rqrsnsditi
      181 seldvdsfde cisptyktgp slhreygsts sidkqgtsge sffdllkgyk ddksdrgptp
      241 tklsdflitg ggkgsgfsld vidgpisqre nlrlfkerek plkrrskset gdssifrklr
      301 nakgeelgks sdlednrsed svrpwtcpkc fahydvqsil fdlneaimnr hnvikrrntt
      361 tgasaaavas lvsgplshsa sfsspmgste dlnskgslsm dqgddksnel vmscpyfrne
      421 iggegerkis lsksnsgsfs gcesasfest lsshctnagv avlevpkenl vlhldrvkry
      481 ivehvdlgay yyrkffyqke hwnyfgaden lgpvavsirr ekpdemkeng spynyriifr
      541 tselmtlrgs vledaipsta khstarglpl kevlehvvpe lnvqclrlaf ntpkvteqlm
      601 kldeqglnyq qkvgimycka gqsteeemyn nesagpafee flqllgervr lkgfekyraq
      661 ldtktdstgt hslyttykdy eimfhvstml pytpnnkqql lrkrhigndi vtivfqepga
      721 qpfspknirs hfqhvfvivr vhnpcsdsvc ysvavtrsrd vpsfgppipk gvtfpksnvf
      781 rdfllakvin aenaahksek framatrtrq eylkdlaekn vtntpidpsg kfpfislask
      841 kkekskpypg aelssmgaiv wavraedynk ameldcllgi snefivlieq etksvvfncs
      901 crdvigwtst dtslkifyer gecvsvgsfi nieeikeivk rlqfvskgce svemtlrrng
      961 lgqlgfhvny egivadvepy gyawqaglrq gsrlveickv avatlsheqm idllrtsvtv
     1021 kvviipphdd ctprrscset yrmpvmeykm negvsyefkf pfrnnnkwqr naskgphspq
     1081 vpsqvqspmt srlnagkgdg kmppperaan iprsissdgr plerrfgvsr rspasidrqn
     1141 tqsdiggsgk stpswqrsed siadqmeptc hlpavskvlp afrespsgrl mrqdpvvhls
     1201 pnkqghsdsh ysshsssntl ssnassahsd ekwydgdrte selnsynylq gtsadsgidt
     1261 tsygpshgst aslgaatssp rsgpgkekva plwhsssevi smadrtlete shgldrktes
     1321 slsldihsks qagstpltre nstfsindaa shtstmssrh saspvvftsa rsspkeelhp
     1381 aapsqlapsf ssssssssgp rsfyprqgat skyligwkkp egtinsvgfm dtrkrhqsdg
     1441 neiahtrlra strdlraspk ptskstieed lkklidlesp tpesqksfkf halsspqspf
     1501 pstptsrral hrtlsdesiy nsqrehffts raslldqalp ndvlfsstyp slpkslplrr
     1561 psytlgmksl hgefsasdss ltdiqetrrq pmpdpglmpl pdtaadldws nlvdaakaye
     1621 vqrasffaas denhrplsaa snsdqledqa laqmkpysss kdssptlask vdqlegmlkm
     1681 lredlkkeke dkahlqaevq hlrednlrlq eesqnasdkl kkftewvfnt idms
//
LOCUS       XP_047287193            1733 aa            linear   PRI 05-AUG-2025
DEFINITION  signal-induced proliferation-associated 1-like protein 1 isoform X7
            [Homo sapiens].
ACCESSION   XP_047287193
VERSION     XP_047287193.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431237.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1733
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1733
                     /product="signal-induced proliferation-associated 1-like
                     protein 1 isoform X7"
                     /calculated_mol_wt=192241
     Region          629..809
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     Region          953..1025
                     /region_name="PDZ_SIPA1-like"
                     /note="PDZ domain of signal-induced
                     proliferation-associated protein 1 (SIPA1), and related
                     domains; cd06745"
                     /db_xref="CDD:467227"
     Site            order(963..969,975,978,1007,1011,1014..1015)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467227"
     Region          1434..1678
                     /region_name="SPAR_C"
                     /note="C-terminal domain of SPAR protein; pfam11881"
                     /db_xref="CDD:463383"
     Region          1666..1721
                     /region_name="ZapB"
                     /note="Cell division protein ZapB; pfam06005"
                     /db_xref="CDD:428718"
     CDS             1..1733
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /coded_by="XM_047431237.1:2252..7453"
                     /db_xref="GeneID:26037"
                     /db_xref="HGNC:HGNC:20284"
                     /db_xref="MIM:617504"
ORIGIN      
        1 mtslkrsqte rplatdrasv vgtdgtpkvh tddfymrrfr sqngslgssv mapvgpprse
       61 gshhitstpg vpkmgvrari adwpprkeni kessrssqei etsscldsls sksspvsqgs
      121 svslnsndsa mlksiqntlk nktrpsenmd srflmpeayp ssprkalrri rqrsnsditi
      181 seldvdsfde cisptyktgp slhreygsts sidkqgtsge sffdllkgyk ddksdrgptp
      241 tklsdflitg ggkgsgfsld vidgpisqre nlrlfkerek plkrrskset gdssifrklr
      301 nakgeelgks sdlednrsed svrpwtcpkc fahydvqsil fdlneaimnr hnvikrrntt
      361 tgasaaavas lvsgplshsa sfsspmgste dlnskgslsm dqgddksnel vmscpyfrne
      421 iggegerkis lsksnsgsfs gcesasfest lsshctnagv avlevpkenl vlhldrvkry
      481 ivehvdlgay yyrkffyqke hwnyfgaden lgpvavsirr ekpdemkeng spynyriifr
      541 tselmtlrgs vledaipsta khstarglpl kevlehvvpe lnvqclrlaf ntpkvteqlm
      601 kldeqglnyq qkvgimycka gqsteeemyn nesagpafee flqllgervr lkgfekyraq
      661 ldtktdstgt hslyttykdy eimfhvstml pytpnnkqql lrkrhigndi vtivfqepga
      721 qpfspknirs hfqhvfvivr vhnpcsdsvc ysvavtrsrd vpsfgppipk gvtfpksnvf
      781 rdfllakvin aenaahksek framatrtrq eylkdlaekn vtntpidpsg kfpfislask
      841 kkekskpypg aelssmgaiv wavraedynk ameldcllgi snefivlieq etksvvfncs
      901 crdvigwtst dtslkifyer gecvsvgsfi nieeikeivk rlqfvskgce svemtlrrng
      961 lgqlgfhvny egivadvepy gyawqaglrq gsrlveickv avatlsheqm idllrtsvtv
     1021 kvviipphdd ctprrscset yrmpvmeykm negvsyefkf pfrnnnkwqr naskgphspq
     1081 vpsqvqspmt srlnagkgdg kmppperaan iprsissdgr plerrfgvsr rspasidrqn
     1141 tqsdiggsgk stpswqrsed siadqmeptc hlpavskvlp afrespsgrl mrqdpvvhls
     1201 pnkqghsdsh ysshsssntl ssnassahsd ekwydgdrte selnsynylq gtsadsgidt
     1261 tsygpshgst aslgaatssp rsgpgkekva plwhsssevi smadrtlete shgldrktes
     1321 slsldihsks qagstpltre nstfsindaa shtstmssrh saspvvftsa rsspkeelhp
     1381 aapsqlapsf ssssssssgp rsfyprqgat skyligwkkp egtinsvgfm dtrkrhqsdg
     1441 neiahtrlra strdlraspk ptskstieed lkklidlesp tpesqksfkf halsspqspf
     1501 pstptsrral hrtlsdesiy nsqrehffts raslldqalp ndvlfsstyp slpkslplrr
     1561 psytlgmksl hgefsasdss ltdiqetrrq pmpdpglmpl pdtaadldws nlvdaakaye
     1621 vqrasffaas denhrplsaa snsdqledqa laqmkpyssk dssptlaskv dqlegmlkml
     1681 redlkkeked kahlqaevqh lrednlrlqe esqnasdklk kftewvfnti dms
//
LOCUS       XP_016876687            1310 aa            linear   PRI 05-AUG-2025
DEFINITION  signal-induced proliferation-associated 1-like protein 1 isoform X8
            [Homo sapiens].
ACCESSION   XP_016876687
VERSION     XP_016876687.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021198.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1310
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1310
                     /product="signal-induced proliferation-associated 1-like
                     protein 1 isoform X8"
                     /calculated_mol_wt=145605
     Region          135..315
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     Region          459..531
                     /region_name="PDZ_SIPA1-like"
                     /note="PDZ domain of signal-induced
                     proliferation-associated protein 1 (SIPA1), and related
                     domains; cd06745"
                     /db_xref="CDD:467227"
     Site            order(469..475,481,484,513,517,520..521)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467227"
     Region          1010..1255
                     /region_name="SPAR_C"
                     /note="C-terminal domain of SPAR protein; pfam11881"
                     /db_xref="CDD:463383"
     Region          1243..1298
                     /region_name="ZapB"
                     /note="Cell division protein ZapB; pfam06005"
                     /db_xref="CDD:428718"
     CDS             1..1310
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /coded_by="XM_017021198.2:235..4167"
                     /db_xref="GeneID:26037"
                     /db_xref="HGNC:HGNC:20284"
                     /db_xref="MIM:617504"
ORIGIN      
        1 maqeykhwny fgadenlgpv avsirrekpd emkengspyn yriifrtsel mtlrgsvled
       61 aipstakhst arglplkevl ehvvpelnvq clrlafntpk vteqlmklde qglnyqqkvg
      121 imyckagqst eeemynnesa gpafeeflql lgervrlkgf ekyraqldtk tdstgthsly
      181 ttykdyeimf hvstmlpytp nnkqqllrkr higndivtiv fqepgaqpfs pknirshfqh
      241 vfvivrvhnp csdsvcysva vtrsrdvpsf gppipkgvtf pksnvfrdfl lakvinaena
      301 ahksekfram atrtrqeylk dlaeknvtnt pidpsgkfpf islaskkkek skpypgaels
      361 smgaivwavr aedynkamel dcllgisnef ivlieqetks vvfncscrdv igwtstdtsl
      421 kifyergecv svgsfiniee ikeivkrlqf vskgcesvem tlrrnglgql gfhvnyegiv
      481 advepygyaw qaglrqgsrl veickvavat lsheqmidll rtsvtvkvvi ipphddctpr
      541 rscsetyrmp vmeykmnegv syefkfpfrn nnkwqrnask gphspqvpsq vqspmtsrln
      601 agkgdgkmpp peraaniprs issdgrpler rlspgsdiyv tvssmalars qcrnspsnls
      661 sssdtgsvgg tyrqksmpeg fgvsrrspas idrqntqsdi ggsgkstpsw qrsedsiadq
      721 maysyrgpqd fnsfvleqhe yteptchlpa vskvlpafre spsgrlmrqd pvvhlspnkq
      781 ghsdshyssh sssntlssna ssahsdekwy dgdrteseln synylqgtsa dsgidttsyg
      841 pshgstaslg aatssprsgp gkekvaplwh sssevismad rtleteshgl drktesslsl
      901 dihsksqags tpltrenstf sindaashts tmssrhsasp vvftsarssp keelhpaaps
      961 qlapsfssss ssssgprsfy prqgatskyl igwkkpegti nsvgfmdtrk rhqsdgneia
     1021 htrlrastrd lraspkptsk stieedlkkl idlesptpes qksfkfhals spqspfpstp
     1081 tsrralhrtl sdesiynsqr ehfftsrasl ldqalpndvl fsstypslpk slplrrpsyt
     1141 lgmkslhgef sasdssltdi qetrrqpmpd pglmplpdta adldwsnlvd aakayevqra
     1201 sffaasdenh rplsaasnsd qledqalaqm kpyssskdss ptlaskvdql egmlkmlred
     1261 lkkekedkah lqaevqhlre dnlrlqeesq nasdklkkft ewvfntidms
//
LOCUS       XP_047287194            1310 aa            linear   PRI 05-AUG-2025
DEFINITION  signal-induced proliferation-associated 1-like protein 1 isoform X8
            [Homo sapiens].
ACCESSION   XP_047287194
VERSION     XP_047287194.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431238.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1310
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1310
                     /product="signal-induced proliferation-associated 1-like
                     protein 1 isoform X8"
                     /calculated_mol_wt=145605
     Region          135..315
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     Region          459..531
                     /region_name="PDZ_SIPA1-like"
                     /note="PDZ domain of signal-induced
                     proliferation-associated protein 1 (SIPA1), and related
                     domains; cd06745"
                     /db_xref="CDD:467227"
     Site            order(469..475,481,484,513,517,520..521)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467227"
     Region          1010..1255
                     /region_name="SPAR_C"
                     /note="C-terminal domain of SPAR protein; pfam11881"
                     /db_xref="CDD:463383"
     Region          1243..1298
                     /region_name="ZapB"
                     /note="Cell division protein ZapB; pfam06005"
                     /db_xref="CDD:428718"
     CDS             1..1310
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /coded_by="XM_047431238.1:302..4234"
                     /db_xref="GeneID:26037"
                     /db_xref="HGNC:HGNC:20284"
                     /db_xref="MIM:617504"
ORIGIN      
        1 maqeykhwny fgadenlgpv avsirrekpd emkengspyn yriifrtsel mtlrgsvled
       61 aipstakhst arglplkevl ehvvpelnvq clrlafntpk vteqlmklde qglnyqqkvg
      121 imyckagqst eeemynnesa gpafeeflql lgervrlkgf ekyraqldtk tdstgthsly
      181 ttykdyeimf hvstmlpytp nnkqqllrkr higndivtiv fqepgaqpfs pknirshfqh
      241 vfvivrvhnp csdsvcysva vtrsrdvpsf gppipkgvtf pksnvfrdfl lakvinaena
      301 ahksekfram atrtrqeylk dlaeknvtnt pidpsgkfpf islaskkkek skpypgaels
      361 smgaivwavr aedynkamel dcllgisnef ivlieqetks vvfncscrdv igwtstdtsl
      421 kifyergecv svgsfiniee ikeivkrlqf vskgcesvem tlrrnglgql gfhvnyegiv
      481 advepygyaw qaglrqgsrl veickvavat lsheqmidll rtsvtvkvvi ipphddctpr
      541 rscsetyrmp vmeykmnegv syefkfpfrn nnkwqrnask gphspqvpsq vqspmtsrln
      601 agkgdgkmpp peraaniprs issdgrpler rlspgsdiyv tvssmalars qcrnspsnls
      661 sssdtgsvgg tyrqksmpeg fgvsrrspas idrqntqsdi ggsgkstpsw qrsedsiadq
      721 maysyrgpqd fnsfvleqhe yteptchlpa vskvlpafre spsgrlmrqd pvvhlspnkq
      781 ghsdshyssh sssntlssna ssahsdekwy dgdrteseln synylqgtsa dsgidttsyg
      841 pshgstaslg aatssprsgp gkekvaplwh sssevismad rtleteshgl drktesslsl
      901 dihsksqags tpltrenstf sindaashts tmssrhsasp vvftsarssp keelhpaaps
      961 qlapsfssss ssssgprsfy prqgatskyl igwkkpegti nsvgfmdtrk rhqsdgneia
     1021 htrlrastrd lraspkptsk stieedlkkl idlesptpes qksfkfhals spqspfpstp
     1081 tsrralhrtl sdesiynsqr ehfftsrasl ldqalpndvl fsstypslpk slplrrpsyt
     1141 lgmkslhgef sasdssltdi qetrrqpmpd pglmplpdta adldwsnlvd aakayevqra
     1201 sffaasdenh rplsaasnsd qledqalaqm kpyssskdss ptlaskvdql egmlkmlred
     1261 lkkekedkah lqaevqhlre dnlrlqeesq nasdklkkft ewvfntidms
//
LOCUS       XP_047287195            1310 aa            linear   PRI 05-AUG-2025
DEFINITION  signal-induced proliferation-associated 1-like protein 1 isoform X8
            [Homo sapiens].
ACCESSION   XP_047287195
VERSION     XP_047287195.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431239.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1310
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1310
                     /product="signal-induced proliferation-associated 1-like
                     protein 1 isoform X8"
                     /calculated_mol_wt=145605
     Region          135..315
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     Region          459..531
                     /region_name="PDZ_SIPA1-like"
                     /note="PDZ domain of signal-induced
                     proliferation-associated protein 1 (SIPA1), and related
                     domains; cd06745"
                     /db_xref="CDD:467227"
     Site            order(469..475,481,484,513,517,520..521)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467227"
     Region          1010..1255
                     /region_name="SPAR_C"
                     /note="C-terminal domain of SPAR protein; pfam11881"
                     /db_xref="CDD:463383"
     Region          1243..1298
                     /region_name="ZapB"
                     /note="Cell division protein ZapB; pfam06005"
                     /db_xref="CDD:428718"
     CDS             1..1310
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /coded_by="XM_047431239.1:369..4301"
                     /db_xref="GeneID:26037"
                     /db_xref="HGNC:HGNC:20284"
                     /db_xref="MIM:617504"
ORIGIN      
        1 maqeykhwny fgadenlgpv avsirrekpd emkengspyn yriifrtsel mtlrgsvled
       61 aipstakhst arglplkevl ehvvpelnvq clrlafntpk vteqlmklde qglnyqqkvg
      121 imyckagqst eeemynnesa gpafeeflql lgervrlkgf ekyraqldtk tdstgthsly
      181 ttykdyeimf hvstmlpytp nnkqqllrkr higndivtiv fqepgaqpfs pknirshfqh
      241 vfvivrvhnp csdsvcysva vtrsrdvpsf gppipkgvtf pksnvfrdfl lakvinaena
      301 ahksekfram atrtrqeylk dlaeknvtnt pidpsgkfpf islaskkkek skpypgaels
      361 smgaivwavr aedynkamel dcllgisnef ivlieqetks vvfncscrdv igwtstdtsl
      421 kifyergecv svgsfiniee ikeivkrlqf vskgcesvem tlrrnglgql gfhvnyegiv
      481 advepygyaw qaglrqgsrl veickvavat lsheqmidll rtsvtvkvvi ipphddctpr
      541 rscsetyrmp vmeykmnegv syefkfpfrn nnkwqrnask gphspqvpsq vqspmtsrln
      601 agkgdgkmpp peraaniprs issdgrpler rlspgsdiyv tvssmalars qcrnspsnls
      661 sssdtgsvgg tyrqksmpeg fgvsrrspas idrqntqsdi ggsgkstpsw qrsedsiadq
      721 maysyrgpqd fnsfvleqhe yteptchlpa vskvlpafre spsgrlmrqd pvvhlspnkq
      781 ghsdshyssh sssntlssna ssahsdekwy dgdrteseln synylqgtsa dsgidttsyg
      841 pshgstaslg aatssprsgp gkekvaplwh sssevismad rtleteshgl drktesslsl
      901 dihsksqags tpltrenstf sindaashts tmssrhsasp vvftsarssp keelhpaaps
      961 qlapsfssss ssssgprsfy prqgatskyl igwkkpegti nsvgfmdtrk rhqsdgneia
     1021 htrlrastrd lraspkptsk stieedlkkl idlesptpes qksfkfhals spqspfpstp
     1081 tsrralhrtl sdesiynsqr ehfftsrasl ldqalpndvl fsstypslpk slplrrpsyt
     1141 lgmkslhgef sasdssltdi qetrrqpmpd pglmplpdta adldwsnlvd aakayevqra
     1201 sffaasdenh rplsaasnsd qledqalaqm kpyssskdss ptlaskvdql egmlkmlred
     1261 lkkekedkah lqaevqhlre dnlrlqeesq nasdklkkft ewvfntidms
//
LOCUS       XP_047287196            1310 aa            linear   PRI 05-AUG-2025
DEFINITION  signal-induced proliferation-associated 1-like protein 1 isoform X8
            [Homo sapiens].
ACCESSION   XP_047287196
VERSION     XP_047287196.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431240.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1310
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1310
                     /product="signal-induced proliferation-associated 1-like
                     protein 1 isoform X8"
                     /calculated_mol_wt=145605
     Region          135..315
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     Region          459..531
                     /region_name="PDZ_SIPA1-like"
                     /note="PDZ domain of signal-induced
                     proliferation-associated protein 1 (SIPA1), and related
                     domains; cd06745"
                     /db_xref="CDD:467227"
     Site            order(469..475,481,484,513,517,520..521)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467227"
     Region          1010..1255
                     /region_name="SPAR_C"
                     /note="C-terminal domain of SPAR protein; pfam11881"
                     /db_xref="CDD:463383"
     Region          1243..1298
                     /region_name="ZapB"
                     /note="Cell division protein ZapB; pfam06005"
                     /db_xref="CDD:428718"
     CDS             1..1310
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /coded_by="XM_047431240.1:2067..5999"
                     /db_xref="GeneID:26037"
                     /db_xref="HGNC:HGNC:20284"
                     /db_xref="MIM:617504"
ORIGIN      
        1 maqeykhwny fgadenlgpv avsirrekpd emkengspyn yriifrtsel mtlrgsvled
       61 aipstakhst arglplkevl ehvvpelnvq clrlafntpk vteqlmklde qglnyqqkvg
      121 imyckagqst eeemynnesa gpafeeflql lgervrlkgf ekyraqldtk tdstgthsly
      181 ttykdyeimf hvstmlpytp nnkqqllrkr higndivtiv fqepgaqpfs pknirshfqh
      241 vfvivrvhnp csdsvcysva vtrsrdvpsf gppipkgvtf pksnvfrdfl lakvinaena
      301 ahksekfram atrtrqeylk dlaeknvtnt pidpsgkfpf islaskkkek skpypgaels
      361 smgaivwavr aedynkamel dcllgisnef ivlieqetks vvfncscrdv igwtstdtsl
      421 kifyergecv svgsfiniee ikeivkrlqf vskgcesvem tlrrnglgql gfhvnyegiv
      481 advepygyaw qaglrqgsrl veickvavat lsheqmidll rtsvtvkvvi ipphddctpr
      541 rscsetyrmp vmeykmnegv syefkfpfrn nnkwqrnask gphspqvpsq vqspmtsrln
      601 agkgdgkmpp peraaniprs issdgrpler rlspgsdiyv tvssmalars qcrnspsnls
      661 sssdtgsvgg tyrqksmpeg fgvsrrspas idrqntqsdi ggsgkstpsw qrsedsiadq
      721 maysyrgpqd fnsfvleqhe yteptchlpa vskvlpafre spsgrlmrqd pvvhlspnkq
      781 ghsdshyssh sssntlssna ssahsdekwy dgdrteseln synylqgtsa dsgidttsyg
      841 pshgstaslg aatssprsgp gkekvaplwh sssevismad rtleteshgl drktesslsl
      901 dihsksqags tpltrenstf sindaashts tmssrhsasp vvftsarssp keelhpaaps
      961 qlapsfssss ssssgprsfy prqgatskyl igwkkpegti nsvgfmdtrk rhqsdgneia
     1021 htrlrastrd lraspkptsk stieedlkkl idlesptpes qksfkfhals spqspfpstp
     1081 tsrralhrtl sdesiynsqr ehfftsrasl ldqalpndvl fsstypslpk slplrrpsyt
     1141 lgmkslhgef sasdssltdi qetrrqpmpd pglmplpdta adldwsnlvd aakayevqra
     1201 sffaasdenh rplsaasnsd qledqalaqm kpyssskdss ptlaskvdql egmlkmlred
     1261 lkkekedkah lqaevqhlre dnlrlqeesq nasdklkkft ewvfntidms
//
LOCUS       XP_047287197            1310 aa            linear   PRI 05-AUG-2025
DEFINITION  signal-induced proliferation-associated 1-like protein 1 isoform X8
            [Homo sapiens].
ACCESSION   XP_047287197
VERSION     XP_047287197.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431241.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1310
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1310
                     /product="signal-induced proliferation-associated 1-like
                     protein 1 isoform X8"
                     /calculated_mol_wt=145605
     Region          135..315
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     Region          459..531
                     /region_name="PDZ_SIPA1-like"
                     /note="PDZ domain of signal-induced
                     proliferation-associated protein 1 (SIPA1), and related
                     domains; cd06745"
                     /db_xref="CDD:467227"
     Site            order(469..475,481,484,513,517,520..521)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467227"
     Region          1010..1255
                     /region_name="SPAR_C"
                     /note="C-terminal domain of SPAR protein; pfam11881"
                     /db_xref="CDD:463383"
     Region          1243..1298
                     /region_name="ZapB"
                     /note="Cell division protein ZapB; pfam06005"
                     /db_xref="CDD:428718"
     CDS             1..1310
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /coded_by="XM_047431241.1:638..4570"
                     /db_xref="GeneID:26037"
                     /db_xref="HGNC:HGNC:20284"
                     /db_xref="MIM:617504"
ORIGIN      
        1 maqeykhwny fgadenlgpv avsirrekpd emkengspyn yriifrtsel mtlrgsvled
       61 aipstakhst arglplkevl ehvvpelnvq clrlafntpk vteqlmklde qglnyqqkvg
      121 imyckagqst eeemynnesa gpafeeflql lgervrlkgf ekyraqldtk tdstgthsly
      181 ttykdyeimf hvstmlpytp nnkqqllrkr higndivtiv fqepgaqpfs pknirshfqh
      241 vfvivrvhnp csdsvcysva vtrsrdvpsf gppipkgvtf pksnvfrdfl lakvinaena
      301 ahksekfram atrtrqeylk dlaeknvtnt pidpsgkfpf islaskkkek skpypgaels
      361 smgaivwavr aedynkamel dcllgisnef ivlieqetks vvfncscrdv igwtstdtsl
      421 kifyergecv svgsfiniee ikeivkrlqf vskgcesvem tlrrnglgql gfhvnyegiv
      481 advepygyaw qaglrqgsrl veickvavat lsheqmidll rtsvtvkvvi ipphddctpr
      541 rscsetyrmp vmeykmnegv syefkfpfrn nnkwqrnask gphspqvpsq vqspmtsrln
      601 agkgdgkmpp peraaniprs issdgrpler rlspgsdiyv tvssmalars qcrnspsnls
      661 sssdtgsvgg tyrqksmpeg fgvsrrspas idrqntqsdi ggsgkstpsw qrsedsiadq
      721 maysyrgpqd fnsfvleqhe yteptchlpa vskvlpafre spsgrlmrqd pvvhlspnkq
      781 ghsdshyssh sssntlssna ssahsdekwy dgdrteseln synylqgtsa dsgidttsyg
      841 pshgstaslg aatssprsgp gkekvaplwh sssevismad rtleteshgl drktesslsl
      901 dihsksqags tpltrenstf sindaashts tmssrhsasp vvftsarssp keelhpaaps
      961 qlapsfssss ssssgprsfy prqgatskyl igwkkpegti nsvgfmdtrk rhqsdgneia
     1021 htrlrastrd lraspkptsk stieedlkkl idlesptpes qksfkfhals spqspfpstp
     1081 tsrralhrtl sdesiynsqr ehfftsrasl ldqalpndvl fsstypslpk slplrrpsyt
     1141 lgmkslhgef sasdssltdi qetrrqpmpd pglmplpdta adldwsnlvd aakayevqra
     1201 sffaasdenh rplsaasnsd qledqalaqm kpyssskdss ptlaskvdql egmlkmlred
     1261 lkkekedkah lqaevqhlre dnlrlqeesq nasdklkkft ewvfntidms
//
LOCUS       XP_047287198            1310 aa            linear   PRI 05-AUG-2025
DEFINITION  signal-induced proliferation-associated 1-like protein 1 isoform X8
            [Homo sapiens].
ACCESSION   XP_047287198
VERSION     XP_047287198.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431242.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1310
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1310
                     /product="signal-induced proliferation-associated 1-like
                     protein 1 isoform X8"
                     /calculated_mol_wt=145605
     Region          135..315
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     Region          459..531
                     /region_name="PDZ_SIPA1-like"
                     /note="PDZ domain of signal-induced
                     proliferation-associated protein 1 (SIPA1), and related
                     domains; cd06745"
                     /db_xref="CDD:467227"
     Site            order(469..475,481,484,513,517,520..521)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467227"
     Region          1010..1255
                     /region_name="SPAR_C"
                     /note="C-terminal domain of SPAR protein; pfam11881"
                     /db_xref="CDD:463383"
     Region          1243..1298
                     /region_name="ZapB"
                     /note="Cell division protein ZapB; pfam06005"
                     /db_xref="CDD:428718"
     CDS             1..1310
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /coded_by="XM_047431242.1:274..4206"
                     /db_xref="GeneID:26037"
                     /db_xref="HGNC:HGNC:20284"
                     /db_xref="MIM:617504"
ORIGIN      
        1 maqeykhwny fgadenlgpv avsirrekpd emkengspyn yriifrtsel mtlrgsvled
       61 aipstakhst arglplkevl ehvvpelnvq clrlafntpk vteqlmklde qglnyqqkvg
      121 imyckagqst eeemynnesa gpafeeflql lgervrlkgf ekyraqldtk tdstgthsly
      181 ttykdyeimf hvstmlpytp nnkqqllrkr higndivtiv fqepgaqpfs pknirshfqh
      241 vfvivrvhnp csdsvcysva vtrsrdvpsf gppipkgvtf pksnvfrdfl lakvinaena
      301 ahksekfram atrtrqeylk dlaeknvtnt pidpsgkfpf islaskkkek skpypgaels
      361 smgaivwavr aedynkamel dcllgisnef ivlieqetks vvfncscrdv igwtstdtsl
      421 kifyergecv svgsfiniee ikeivkrlqf vskgcesvem tlrrnglgql gfhvnyegiv
      481 advepygyaw qaglrqgsrl veickvavat lsheqmidll rtsvtvkvvi ipphddctpr
      541 rscsetyrmp vmeykmnegv syefkfpfrn nnkwqrnask gphspqvpsq vqspmtsrln
      601 agkgdgkmpp peraaniprs issdgrpler rlspgsdiyv tvssmalars qcrnspsnls
      661 sssdtgsvgg tyrqksmpeg fgvsrrspas idrqntqsdi ggsgkstpsw qrsedsiadq
      721 maysyrgpqd fnsfvleqhe yteptchlpa vskvlpafre spsgrlmrqd pvvhlspnkq
      781 ghsdshyssh sssntlssna ssahsdekwy dgdrteseln synylqgtsa dsgidttsyg
      841 pshgstaslg aatssprsgp gkekvaplwh sssevismad rtleteshgl drktesslsl
      901 dihsksqags tpltrenstf sindaashts tmssrhsasp vvftsarssp keelhpaaps
      961 qlapsfssss ssssgprsfy prqgatskyl igwkkpegti nsvgfmdtrk rhqsdgneia
     1021 htrlrastrd lraspkptsk stieedlkkl idlesptpes qksfkfhals spqspfpstp
     1081 tsrralhrtl sdesiynsqr ehfftsrasl ldqalpndvl fsstypslpk slplrrpsyt
     1141 lgmkslhgef sasdssltdi qetrrqpmpd pglmplpdta adldwsnlvd aakayevqra
     1201 sffaasdenh rplsaasnsd qledqalaqm kpyssskdss ptlaskvdql egmlkmlred
     1261 lkkekedkah lqaevqhlre dnlrlqeesq nasdklkkft ewvfntidms
//
LOCUS       XP_047287199            1310 aa            linear   PRI 05-AUG-2025
DEFINITION  signal-induced proliferation-associated 1-like protein 1 isoform X8
            [Homo sapiens].
ACCESSION   XP_047287199
VERSION     XP_047287199.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431243.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1310
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1310
                     /product="signal-induced proliferation-associated 1-like
                     protein 1 isoform X8"
                     /calculated_mol_wt=145605
     Region          135..315
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     Region          459..531
                     /region_name="PDZ_SIPA1-like"
                     /note="PDZ domain of signal-induced
                     proliferation-associated protein 1 (SIPA1), and related
                     domains; cd06745"
                     /db_xref="CDD:467227"
     Site            order(469..475,481,484,513,517,520..521)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467227"
     Region          1010..1255
                     /region_name="SPAR_C"
                     /note="C-terminal domain of SPAR protein; pfam11881"
                     /db_xref="CDD:463383"
     Region          1243..1298
                     /region_name="ZapB"
                     /note="Cell division protein ZapB; pfam06005"
                     /db_xref="CDD:428718"
     CDS             1..1310
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /coded_by="XM_047431243.1:360..4292"
                     /db_xref="GeneID:26037"
                     /db_xref="HGNC:HGNC:20284"
                     /db_xref="MIM:617504"
ORIGIN      
        1 maqeykhwny fgadenlgpv avsirrekpd emkengspyn yriifrtsel mtlrgsvled
       61 aipstakhst arglplkevl ehvvpelnvq clrlafntpk vteqlmklde qglnyqqkvg
      121 imyckagqst eeemynnesa gpafeeflql lgervrlkgf ekyraqldtk tdstgthsly
      181 ttykdyeimf hvstmlpytp nnkqqllrkr higndivtiv fqepgaqpfs pknirshfqh
      241 vfvivrvhnp csdsvcysva vtrsrdvpsf gppipkgvtf pksnvfrdfl lakvinaena
      301 ahksekfram atrtrqeylk dlaeknvtnt pidpsgkfpf islaskkkek skpypgaels
      361 smgaivwavr aedynkamel dcllgisnef ivlieqetks vvfncscrdv igwtstdtsl
      421 kifyergecv svgsfiniee ikeivkrlqf vskgcesvem tlrrnglgql gfhvnyegiv
      481 advepygyaw qaglrqgsrl veickvavat lsheqmidll rtsvtvkvvi ipphddctpr
      541 rscsetyrmp vmeykmnegv syefkfpfrn nnkwqrnask gphspqvpsq vqspmtsrln
      601 agkgdgkmpp peraaniprs issdgrpler rlspgsdiyv tvssmalars qcrnspsnls
      661 sssdtgsvgg tyrqksmpeg fgvsrrspas idrqntqsdi ggsgkstpsw qrsedsiadq
      721 maysyrgpqd fnsfvleqhe yteptchlpa vskvlpafre spsgrlmrqd pvvhlspnkq
      781 ghsdshyssh sssntlssna ssahsdekwy dgdrteseln synylqgtsa dsgidttsyg
      841 pshgstaslg aatssprsgp gkekvaplwh sssevismad rtleteshgl drktesslsl
      901 dihsksqags tpltrenstf sindaashts tmssrhsasp vvftsarssp keelhpaaps
      961 qlapsfssss ssssgprsfy prqgatskyl igwkkpegti nsvgfmdtrk rhqsdgneia
     1021 htrlrastrd lraspkptsk stieedlkkl idlesptpes qksfkfhals spqspfpstp
     1081 tsrralhrtl sdesiynsqr ehfftsrasl ldqalpndvl fsstypslpk slplrrpsyt
     1141 lgmkslhgef sasdssltdi qetrrqpmpd pglmplpdta adldwsnlvd aakayevqra
     1201 sffaasdenh rplsaasnsd qledqalaqm kpyssskdss ptlaskvdql egmlkmlred
     1261 lkkekedkah lqaevqhlre dnlrlqeesq nasdklkkft ewvfntidms
//
LOCUS       XP_047287200            1310 aa            linear   PRI 05-AUG-2025
DEFINITION  signal-induced proliferation-associated 1-like protein 1 isoform X8
            [Homo sapiens].
ACCESSION   XP_047287200
VERSION     XP_047287200.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431244.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1310
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1310
                     /product="signal-induced proliferation-associated 1-like
                     protein 1 isoform X8"
                     /calculated_mol_wt=145605
     Region          135..315
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     Region          459..531
                     /region_name="PDZ_SIPA1-like"
                     /note="PDZ domain of signal-induced
                     proliferation-associated protein 1 (SIPA1), and related
                     domains; cd06745"
                     /db_xref="CDD:467227"
     Site            order(469..475,481,484,513,517,520..521)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467227"
     Region          1010..1255
                     /region_name="SPAR_C"
                     /note="C-terminal domain of SPAR protein; pfam11881"
                     /db_xref="CDD:463383"
     Region          1243..1298
                     /region_name="ZapB"
                     /note="Cell division protein ZapB; pfam06005"
                     /db_xref="CDD:428718"
     CDS             1..1310
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /coded_by="XM_047431244.1:1923..5855"
                     /db_xref="GeneID:26037"
                     /db_xref="HGNC:HGNC:20284"
                     /db_xref="MIM:617504"
ORIGIN      
        1 maqeykhwny fgadenlgpv avsirrekpd emkengspyn yriifrtsel mtlrgsvled
       61 aipstakhst arglplkevl ehvvpelnvq clrlafntpk vteqlmklde qglnyqqkvg
      121 imyckagqst eeemynnesa gpafeeflql lgervrlkgf ekyraqldtk tdstgthsly
      181 ttykdyeimf hvstmlpytp nnkqqllrkr higndivtiv fqepgaqpfs pknirshfqh
      241 vfvivrvhnp csdsvcysva vtrsrdvpsf gppipkgvtf pksnvfrdfl lakvinaena
      301 ahksekfram atrtrqeylk dlaeknvtnt pidpsgkfpf islaskkkek skpypgaels
      361 smgaivwavr aedynkamel dcllgisnef ivlieqetks vvfncscrdv igwtstdtsl
      421 kifyergecv svgsfiniee ikeivkrlqf vskgcesvem tlrrnglgql gfhvnyegiv
      481 advepygyaw qaglrqgsrl veickvavat lsheqmidll rtsvtvkvvi ipphddctpr
      541 rscsetyrmp vmeykmnegv syefkfpfrn nnkwqrnask gphspqvpsq vqspmtsrln
      601 agkgdgkmpp peraaniprs issdgrpler rlspgsdiyv tvssmalars qcrnspsnls
      661 sssdtgsvgg tyrqksmpeg fgvsrrspas idrqntqsdi ggsgkstpsw qrsedsiadq
      721 maysyrgpqd fnsfvleqhe yteptchlpa vskvlpafre spsgrlmrqd pvvhlspnkq
      781 ghsdshyssh sssntlssna ssahsdekwy dgdrteseln synylqgtsa dsgidttsyg
      841 pshgstaslg aatssprsgp gkekvaplwh sssevismad rtleteshgl drktesslsl
      901 dihsksqags tpltrenstf sindaashts tmssrhsasp vvftsarssp keelhpaaps
      961 qlapsfssss ssssgprsfy prqgatskyl igwkkpegti nsvgfmdtrk rhqsdgneia
     1021 htrlrastrd lraspkptsk stieedlkkl idlesptpes qksfkfhals spqspfpstp
     1081 tsrralhrtl sdesiynsqr ehfftsrasl ldqalpndvl fsstypslpk slplrrpsyt
     1141 lgmkslhgef sasdssltdi qetrrqpmpd pglmplpdta adldwsnlvd aakayevqra
     1201 sffaasdenh rplsaasnsd qledqalaqm kpyssskdss ptlaskvdql egmlkmlred
     1261 lkkekedkah lqaevqhlre dnlrlqeesq nasdklkkft ewvfntidms
//
LOCUS       XP_047287201            1310 aa            linear   PRI 05-AUG-2025
DEFINITION  signal-induced proliferation-associated 1-like protein 1 isoform X8
            [Homo sapiens].
ACCESSION   XP_047287201
VERSION     XP_047287201.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431245.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1310
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1310
                     /product="signal-induced proliferation-associated 1-like
                     protein 1 isoform X8"
                     /calculated_mol_wt=145605
     Region          135..315
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     Region          459..531
                     /region_name="PDZ_SIPA1-like"
                     /note="PDZ domain of signal-induced
                     proliferation-associated protein 1 (SIPA1), and related
                     domains; cd06745"
                     /db_xref="CDD:467227"
     Site            order(469..475,481,484,513,517,520..521)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467227"
     Region          1010..1255
                     /region_name="SPAR_C"
                     /note="C-terminal domain of SPAR protein; pfam11881"
                     /db_xref="CDD:463383"
     Region          1243..1298
                     /region_name="ZapB"
                     /note="Cell division protein ZapB; pfam06005"
                     /db_xref="CDD:428718"
     CDS             1..1310
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /coded_by="XM_047431245.1:344..4276"
                     /db_xref="GeneID:26037"
                     /db_xref="HGNC:HGNC:20284"
                     /db_xref="MIM:617504"
ORIGIN      
        1 maqeykhwny fgadenlgpv avsirrekpd emkengspyn yriifrtsel mtlrgsvled
       61 aipstakhst arglplkevl ehvvpelnvq clrlafntpk vteqlmklde qglnyqqkvg
      121 imyckagqst eeemynnesa gpafeeflql lgervrlkgf ekyraqldtk tdstgthsly
      181 ttykdyeimf hvstmlpytp nnkqqllrkr higndivtiv fqepgaqpfs pknirshfqh
      241 vfvivrvhnp csdsvcysva vtrsrdvpsf gppipkgvtf pksnvfrdfl lakvinaena
      301 ahksekfram atrtrqeylk dlaeknvtnt pidpsgkfpf islaskkkek skpypgaels
      361 smgaivwavr aedynkamel dcllgisnef ivlieqetks vvfncscrdv igwtstdtsl
      421 kifyergecv svgsfiniee ikeivkrlqf vskgcesvem tlrrnglgql gfhvnyegiv
      481 advepygyaw qaglrqgsrl veickvavat lsheqmidll rtsvtvkvvi ipphddctpr
      541 rscsetyrmp vmeykmnegv syefkfpfrn nnkwqrnask gphspqvpsq vqspmtsrln
      601 agkgdgkmpp peraaniprs issdgrpler rlspgsdiyv tvssmalars qcrnspsnls
      661 sssdtgsvgg tyrqksmpeg fgvsrrspas idrqntqsdi ggsgkstpsw qrsedsiadq
      721 maysyrgpqd fnsfvleqhe yteptchlpa vskvlpafre spsgrlmrqd pvvhlspnkq
      781 ghsdshyssh sssntlssna ssahsdekwy dgdrteseln synylqgtsa dsgidttsyg
      841 pshgstaslg aatssprsgp gkekvaplwh sssevismad rtleteshgl drktesslsl
      901 dihsksqags tpltrenstf sindaashts tmssrhsasp vvftsarssp keelhpaaps
      961 qlapsfssss ssssgprsfy prqgatskyl igwkkpegti nsvgfmdtrk rhqsdgneia
     1021 htrlrastrd lraspkptsk stieedlkkl idlesptpes qksfkfhals spqspfpstp
     1081 tsrralhrtl sdesiynsqr ehfftsrasl ldqalpndvl fsstypslpk slplrrpsyt
     1141 lgmkslhgef sasdssltdi qetrrqpmpd pglmplpdta adldwsnlvd aakayevqra
     1201 sffaasdenh rplsaasnsd qledqalaqm kpyssskdss ptlaskvdql egmlkmlred
     1261 lkkekedkah lqaevqhlre dnlrlqeesq nasdklkkft ewvfntidms
//
LOCUS       XP_047287202            1310 aa            linear   PRI 05-AUG-2025
DEFINITION  signal-induced proliferation-associated 1-like protein 1 isoform X8
            [Homo sapiens].
ACCESSION   XP_047287202
VERSION     XP_047287202.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431246.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1310
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1310
                     /product="signal-induced proliferation-associated 1-like
                     protein 1 isoform X8"
                     /calculated_mol_wt=145605
     Region          135..315
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     Region          459..531
                     /region_name="PDZ_SIPA1-like"
                     /note="PDZ domain of signal-induced
                     proliferation-associated protein 1 (SIPA1), and related
                     domains; cd06745"
                     /db_xref="CDD:467227"
     Site            order(469..475,481,484,513,517,520..521)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467227"
     Region          1010..1255
                     /region_name="SPAR_C"
                     /note="C-terminal domain of SPAR protein; pfam11881"
                     /db_xref="CDD:463383"
     Region          1243..1298
                     /region_name="ZapB"
                     /note="Cell division protein ZapB; pfam06005"
                     /db_xref="CDD:428718"
     CDS             1..1310
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /coded_by="XM_047431246.1:277..4209"
                     /db_xref="GeneID:26037"
                     /db_xref="HGNC:HGNC:20284"
                     /db_xref="MIM:617504"
ORIGIN      
        1 maqeykhwny fgadenlgpv avsirrekpd emkengspyn yriifrtsel mtlrgsvled
       61 aipstakhst arglplkevl ehvvpelnvq clrlafntpk vteqlmklde qglnyqqkvg
      121 imyckagqst eeemynnesa gpafeeflql lgervrlkgf ekyraqldtk tdstgthsly
      181 ttykdyeimf hvstmlpytp nnkqqllrkr higndivtiv fqepgaqpfs pknirshfqh
      241 vfvivrvhnp csdsvcysva vtrsrdvpsf gppipkgvtf pksnvfrdfl lakvinaena
      301 ahksekfram atrtrqeylk dlaeknvtnt pidpsgkfpf islaskkkek skpypgaels
      361 smgaivwavr aedynkamel dcllgisnef ivlieqetks vvfncscrdv igwtstdtsl
      421 kifyergecv svgsfiniee ikeivkrlqf vskgcesvem tlrrnglgql gfhvnyegiv
      481 advepygyaw qaglrqgsrl veickvavat lsheqmidll rtsvtvkvvi ipphddctpr
      541 rscsetyrmp vmeykmnegv syefkfpfrn nnkwqrnask gphspqvpsq vqspmtsrln
      601 agkgdgkmpp peraaniprs issdgrpler rlspgsdiyv tvssmalars qcrnspsnls
      661 sssdtgsvgg tyrqksmpeg fgvsrrspas idrqntqsdi ggsgkstpsw qrsedsiadq
      721 maysyrgpqd fnsfvleqhe yteptchlpa vskvlpafre spsgrlmrqd pvvhlspnkq
      781 ghsdshyssh sssntlssna ssahsdekwy dgdrteseln synylqgtsa dsgidttsyg
      841 pshgstaslg aatssprsgp gkekvaplwh sssevismad rtleteshgl drktesslsl
      901 dihsksqags tpltrenstf sindaashts tmssrhsasp vvftsarssp keelhpaaps
      961 qlapsfssss ssssgprsfy prqgatskyl igwkkpegti nsvgfmdtrk rhqsdgneia
     1021 htrlrastrd lraspkptsk stieedlkkl idlesptpes qksfkfhals spqspfpstp
     1081 tsrralhrtl sdesiynsqr ehfftsrasl ldqalpndvl fsstypslpk slplrrpsyt
     1141 lgmkslhgef sasdssltdi qetrrqpmpd pglmplpdta adldwsnlvd aakayevqra
     1201 sffaasdenh rplsaasnsd qledqalaqm kpyssskdss ptlaskvdql egmlkmlred
     1261 lkkekedkah lqaevqhlre dnlrlqeesq nasdklkkft ewvfntidms
//
LOCUS       XP_047287203            1289 aa            linear   PRI 05-AUG-2025
DEFINITION  signal-induced proliferation-associated 1-like protein 1 isoform X9
            [Homo sapiens].
ACCESSION   XP_047287203
VERSION     XP_047287203.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431247.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1289
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1289
                     /product="signal-induced proliferation-associated 1-like
                     protein 1 isoform X9"
                     /calculated_mol_wt=143071
     Region          135..315
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     Region          459..531
                     /region_name="PDZ_SIPA1-like"
                     /note="PDZ domain of signal-induced
                     proliferation-associated protein 1 (SIPA1), and related
                     domains; cd06745"
                     /db_xref="CDD:467227"
     Site            order(469..475,481,484,513,517,520..521)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467227"
     Region          989..1234
                     /region_name="SPAR_C"
                     /note="C-terminal domain of SPAR protein; pfam11881"
                     /db_xref="CDD:463383"
     Region          1222..1277
                     /region_name="ZapB"
                     /note="Cell division protein ZapB; pfam06005"
                     /db_xref="CDD:428718"
     CDS             1..1289
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /coded_by="XM_047431247.1:302..4171"
                     /db_xref="GeneID:26037"
                     /db_xref="HGNC:HGNC:20284"
                     /db_xref="MIM:617504"
ORIGIN      
        1 maqeykhwny fgadenlgpv avsirrekpd emkengspyn yriifrtsel mtlrgsvled
       61 aipstakhst arglplkevl ehvvpelnvq clrlafntpk vteqlmklde qglnyqqkvg
      121 imyckagqst eeemynnesa gpafeeflql lgervrlkgf ekyraqldtk tdstgthsly
      181 ttykdyeimf hvstmlpytp nnkqqllrkr higndivtiv fqepgaqpfs pknirshfqh
      241 vfvivrvhnp csdsvcysva vtrsrdvpsf gppipkgvtf pksnvfrdfl lakvinaena
      301 ahksekfram atrtrqeylk dlaeknvtnt pidpsgkfpf islaskkkek skpypgaels
      361 smgaivwavr aedynkamel dcllgisnef ivlieqetks vvfncscrdv igwtstdtsl
      421 kifyergecv svgsfiniee ikeivkrlqf vskgcesvem tlrrnglgql gfhvnyegiv
      481 advepygyaw qaglrqgsrl veickvavat lsheqmidll rtsvtvkvvi ipphddctpr
      541 rscsetyrmp vmeykmnegv syefkfpfrn nnkwqrnask gphspqvpsq vqspmtsrln
      601 agkgdgkmpp peraaniprs issdgrpler rlspgsdiyv tvssmalars qcrnspsnls
      661 sssdtgsvgg tyrqksmpeg fgvsrrspas idrqntqsdi ggsgkstpsw qrsedsiadq
      721 meptchlpav skvlpafres psgrlmrqdp vvhlspnkqg hsdshysshs ssntlssnas
      781 sahsdekwyd gdrteselns ynylqgtsad sgidttsygp shgstaslga atssprsgpg
      841 kekvaplwhs ssevismadr tleteshgld rktesslsld ihsksqagst pltrenstfs
      901 indaashtst mssrhsaspv vftsarsspk eelhpaapsq lapsfsssss sssgprsfyp
      961 rqgatskyli gwkkpegtin svgfmdtrkr hqsdgneiah trlrastrdl raspkptsks
     1021 tieedlkkli dlesptpesq ksfkfhalss pqspfpstpt srralhrtls desiynsqre
     1081 hfftsrasll dqalpndvlf sstypslpks lplrrpsytl gmkslhgefs asdssltdiq
     1141 etrrqpmpdp glmplpdtaa dldwsnlvda akayevqras ffaasdenhr plsaasnsdq
     1201 ledqalaqmk pyssskdssp tlaskvdqle gmlkmlredl kkekedkahl qaevqhlred
     1261 nlrlqeesqn asdklkkfte wvfntidms
//
LOCUS       XP_047287204            1289 aa            linear   PRI 05-AUG-2025
DEFINITION  signal-induced proliferation-associated 1-like protein 1 isoform X9
            [Homo sapiens].
ACCESSION   XP_047287204
VERSION     XP_047287204.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431248.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1289
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1289
                     /product="signal-induced proliferation-associated 1-like
                     protein 1 isoform X9"
                     /calculated_mol_wt=143071
     Region          135..315
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     Region          459..531
                     /region_name="PDZ_SIPA1-like"
                     /note="PDZ domain of signal-induced
                     proliferation-associated protein 1 (SIPA1), and related
                     domains; cd06745"
                     /db_xref="CDD:467227"
     Site            order(469..475,481,484,513,517,520..521)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467227"
     Region          989..1234
                     /region_name="SPAR_C"
                     /note="C-terminal domain of SPAR protein; pfam11881"
                     /db_xref="CDD:463383"
     Region          1222..1277
                     /region_name="ZapB"
                     /note="Cell division protein ZapB; pfam06005"
                     /db_xref="CDD:428718"
     CDS             1..1289
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /coded_by="XM_047431248.1:705..4574"
                     /db_xref="GeneID:26037"
                     /db_xref="HGNC:HGNC:20284"
                     /db_xref="MIM:617504"
ORIGIN      
        1 maqeykhwny fgadenlgpv avsirrekpd emkengspyn yriifrtsel mtlrgsvled
       61 aipstakhst arglplkevl ehvvpelnvq clrlafntpk vteqlmklde qglnyqqkvg
      121 imyckagqst eeemynnesa gpafeeflql lgervrlkgf ekyraqldtk tdstgthsly
      181 ttykdyeimf hvstmlpytp nnkqqllrkr higndivtiv fqepgaqpfs pknirshfqh
      241 vfvivrvhnp csdsvcysva vtrsrdvpsf gppipkgvtf pksnvfrdfl lakvinaena
      301 ahksekfram atrtrqeylk dlaeknvtnt pidpsgkfpf islaskkkek skpypgaels
      361 smgaivwavr aedynkamel dcllgisnef ivlieqetks vvfncscrdv igwtstdtsl
      421 kifyergecv svgsfiniee ikeivkrlqf vskgcesvem tlrrnglgql gfhvnyegiv
      481 advepygyaw qaglrqgsrl veickvavat lsheqmidll rtsvtvkvvi ipphddctpr
      541 rscsetyrmp vmeykmnegv syefkfpfrn nnkwqrnask gphspqvpsq vqspmtsrln
      601 agkgdgkmpp peraaniprs issdgrpler rlspgsdiyv tvssmalars qcrnspsnls
      661 sssdtgsvgg tyrqksmpeg fgvsrrspas idrqntqsdi ggsgkstpsw qrsedsiadq
      721 meptchlpav skvlpafres psgrlmrqdp vvhlspnkqg hsdshysshs ssntlssnas
      781 sahsdekwyd gdrteselns ynylqgtsad sgidttsygp shgstaslga atssprsgpg
      841 kekvaplwhs ssevismadr tleteshgld rktesslsld ihsksqagst pltrenstfs
      901 indaashtst mssrhsaspv vftsarsspk eelhpaapsq lapsfsssss sssgprsfyp
      961 rqgatskyli gwkkpegtin svgfmdtrkr hqsdgneiah trlrastrdl raspkptsks
     1021 tieedlkkli dlesptpesq ksfkfhalss pqspfpstpt srralhrtls desiynsqre
     1081 hfftsrasll dqalpndvlf sstypslpks lplrrpsytl gmkslhgefs asdssltdiq
     1141 etrrqpmpdp glmplpdtaa dldwsnlvda akayevqras ffaasdenhr plsaasnsdq
     1201 ledqalaqmk pyssskdssp tlaskvdqle gmlkmlredl kkekedkahl qaevqhlred
     1261 nlrlqeesqn asdklkkfte wvfntidms
//
LOCUS       XP_047287205            1289 aa            linear   PRI 05-AUG-2025
DEFINITION  signal-induced proliferation-associated 1-like protein 1 isoform X9
            [Homo sapiens].
ACCESSION   XP_047287205
VERSION     XP_047287205.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431249.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1289
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1289
                     /product="signal-induced proliferation-associated 1-like
                     protein 1 isoform X9"
                     /calculated_mol_wt=143071
     Region          135..315
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     Region          459..531
                     /region_name="PDZ_SIPA1-like"
                     /note="PDZ domain of signal-induced
                     proliferation-associated protein 1 (SIPA1), and related
                     domains; cd06745"
                     /db_xref="CDD:467227"
     Site            order(469..475,481,484,513,517,520..521)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467227"
     Region          989..1234
                     /region_name="SPAR_C"
                     /note="C-terminal domain of SPAR protein; pfam11881"
                     /db_xref="CDD:463383"
     Region          1222..1277
                     /region_name="ZapB"
                     /note="Cell division protein ZapB; pfam06005"
                     /db_xref="CDD:428718"
     CDS             1..1289
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /coded_by="XM_047431249.1:235..4104"
                     /db_xref="GeneID:26037"
                     /db_xref="HGNC:HGNC:20284"
                     /db_xref="MIM:617504"
ORIGIN      
        1 maqeykhwny fgadenlgpv avsirrekpd emkengspyn yriifrtsel mtlrgsvled
       61 aipstakhst arglplkevl ehvvpelnvq clrlafntpk vteqlmklde qglnyqqkvg
      121 imyckagqst eeemynnesa gpafeeflql lgervrlkgf ekyraqldtk tdstgthsly
      181 ttykdyeimf hvstmlpytp nnkqqllrkr higndivtiv fqepgaqpfs pknirshfqh
      241 vfvivrvhnp csdsvcysva vtrsrdvpsf gppipkgvtf pksnvfrdfl lakvinaena
      301 ahksekfram atrtrqeylk dlaeknvtnt pidpsgkfpf islaskkkek skpypgaels
      361 smgaivwavr aedynkamel dcllgisnef ivlieqetks vvfncscrdv igwtstdtsl
      421 kifyergecv svgsfiniee ikeivkrlqf vskgcesvem tlrrnglgql gfhvnyegiv
      481 advepygyaw qaglrqgsrl veickvavat lsheqmidll rtsvtvkvvi ipphddctpr
      541 rscsetyrmp vmeykmnegv syefkfpfrn nnkwqrnask gphspqvpsq vqspmtsrln
      601 agkgdgkmpp peraaniprs issdgrpler rlspgsdiyv tvssmalars qcrnspsnls
      661 sssdtgsvgg tyrqksmpeg fgvsrrspas idrqntqsdi ggsgkstpsw qrsedsiadq
      721 meptchlpav skvlpafres psgrlmrqdp vvhlspnkqg hsdshysshs ssntlssnas
      781 sahsdekwyd gdrteselns ynylqgtsad sgidttsygp shgstaslga atssprsgpg
      841 kekvaplwhs ssevismadr tleteshgld rktesslsld ihsksqagst pltrenstfs
      901 indaashtst mssrhsaspv vftsarsspk eelhpaapsq lapsfsssss sssgprsfyp
      961 rqgatskyli gwkkpegtin svgfmdtrkr hqsdgneiah trlrastrdl raspkptsks
     1021 tieedlkkli dlesptpesq ksfkfhalss pqspfpstpt srralhrtls desiynsqre
     1081 hfftsrasll dqalpndvlf sstypslpks lplrrpsytl gmkslhgefs asdssltdiq
     1141 etrrqpmpdp glmplpdtaa dldwsnlvda akayevqras ffaasdenhr plsaasnsdq
     1201 ledqalaqmk pyssskdssp tlaskvdqle gmlkmlredl kkekedkahl qaevqhlred
     1261 nlrlqeesqn asdklkkfte wvfntidms
//
LOCUS       XP_047287206            1289 aa            linear   PRI 05-AUG-2025
DEFINITION  signal-induced proliferation-associated 1-like protein 1 isoform X9
            [Homo sapiens].
ACCESSION   XP_047287206
VERSION     XP_047287206.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431250.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1289
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1289
                     /product="signal-induced proliferation-associated 1-like
                     protein 1 isoform X9"
                     /calculated_mol_wt=143071
     Region          135..315
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     Region          459..531
                     /region_name="PDZ_SIPA1-like"
                     /note="PDZ domain of signal-induced
                     proliferation-associated protein 1 (SIPA1), and related
                     domains; cd06745"
                     /db_xref="CDD:467227"
     Site            order(469..475,481,484,513,517,520..521)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467227"
     Region          989..1234
                     /region_name="SPAR_C"
                     /note="C-terminal domain of SPAR protein; pfam11881"
                     /db_xref="CDD:463383"
     Region          1222..1277
                     /region_name="ZapB"
                     /note="Cell division protein ZapB; pfam06005"
                     /db_xref="CDD:428718"
     CDS             1..1289
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /coded_by="XM_047431250.1:571..4440"
                     /db_xref="GeneID:26037"
                     /db_xref="HGNC:HGNC:20284"
                     /db_xref="MIM:617504"
ORIGIN      
        1 maqeykhwny fgadenlgpv avsirrekpd emkengspyn yriifrtsel mtlrgsvled
       61 aipstakhst arglplkevl ehvvpelnvq clrlafntpk vteqlmklde qglnyqqkvg
      121 imyckagqst eeemynnesa gpafeeflql lgervrlkgf ekyraqldtk tdstgthsly
      181 ttykdyeimf hvstmlpytp nnkqqllrkr higndivtiv fqepgaqpfs pknirshfqh
      241 vfvivrvhnp csdsvcysva vtrsrdvpsf gppipkgvtf pksnvfrdfl lakvinaena
      301 ahksekfram atrtrqeylk dlaeknvtnt pidpsgkfpf islaskkkek skpypgaels
      361 smgaivwavr aedynkamel dcllgisnef ivlieqetks vvfncscrdv igwtstdtsl
      421 kifyergecv svgsfiniee ikeivkrlqf vskgcesvem tlrrnglgql gfhvnyegiv
      481 advepygyaw qaglrqgsrl veickvavat lsheqmidll rtsvtvkvvi ipphddctpr
      541 rscsetyrmp vmeykmnegv syefkfpfrn nnkwqrnask gphspqvpsq vqspmtsrln
      601 agkgdgkmpp peraaniprs issdgrpler rlspgsdiyv tvssmalars qcrnspsnls
      661 sssdtgsvgg tyrqksmpeg fgvsrrspas idrqntqsdi ggsgkstpsw qrsedsiadq
      721 meptchlpav skvlpafres psgrlmrqdp vvhlspnkqg hsdshysshs ssntlssnas
      781 sahsdekwyd gdrteselns ynylqgtsad sgidttsygp shgstaslga atssprsgpg
      841 kekvaplwhs ssevismadr tleteshgld rktesslsld ihsksqagst pltrenstfs
      901 indaashtst mssrhsaspv vftsarsspk eelhpaapsq lapsfsssss sssgprsfyp
      961 rqgatskyli gwkkpegtin svgfmdtrkr hqsdgneiah trlrastrdl raspkptsks
     1021 tieedlkkli dlesptpesq ksfkfhalss pqspfpstpt srralhrtls desiynsqre
     1081 hfftsrasll dqalpndvlf sstypslpks lplrrpsytl gmkslhgefs asdssltdiq
     1141 etrrqpmpdp glmplpdtaa dldwsnlvda akayevqras ffaasdenhr plsaasnsdq
     1201 ledqalaqmk pyssskdssp tlaskvdqle gmlkmlredl kkekedkahl qaevqhlred
     1261 nlrlqeesqn asdklkkfte wvfntidms
//
LOCUS       XP_047287207            1289 aa            linear   PRI 05-AUG-2025
DEFINITION  signal-induced proliferation-associated 1-like protein 1 isoform X9
            [Homo sapiens].
ACCESSION   XP_047287207
VERSION     XP_047287207.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431251.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1289
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1289
                     /product="signal-induced proliferation-associated 1-like
                     protein 1 isoform X9"
                     /calculated_mol_wt=143071
     Region          135..315
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     Region          459..531
                     /region_name="PDZ_SIPA1-like"
                     /note="PDZ domain of signal-induced
                     proliferation-associated protein 1 (SIPA1), and related
                     domains; cd06745"
                     /db_xref="CDD:467227"
     Site            order(469..475,481,484,513,517,520..521)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467227"
     Region          989..1234
                     /region_name="SPAR_C"
                     /note="C-terminal domain of SPAR protein; pfam11881"
                     /db_xref="CDD:463383"
     Region          1222..1277
                     /region_name="ZapB"
                     /note="Cell division protein ZapB; pfam06005"
                     /db_xref="CDD:428718"
     CDS             1..1289
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /coded_by="XM_047431251.1:468..4337"
                     /db_xref="GeneID:26037"
                     /db_xref="HGNC:HGNC:20284"
                     /db_xref="MIM:617504"
ORIGIN      
        1 maqeykhwny fgadenlgpv avsirrekpd emkengspyn yriifrtsel mtlrgsvled
       61 aipstakhst arglplkevl ehvvpelnvq clrlafntpk vteqlmklde qglnyqqkvg
      121 imyckagqst eeemynnesa gpafeeflql lgervrlkgf ekyraqldtk tdstgthsly
      181 ttykdyeimf hvstmlpytp nnkqqllrkr higndivtiv fqepgaqpfs pknirshfqh
      241 vfvivrvhnp csdsvcysva vtrsrdvpsf gppipkgvtf pksnvfrdfl lakvinaena
      301 ahksekfram atrtrqeylk dlaeknvtnt pidpsgkfpf islaskkkek skpypgaels
      361 smgaivwavr aedynkamel dcllgisnef ivlieqetks vvfncscrdv igwtstdtsl
      421 kifyergecv svgsfiniee ikeivkrlqf vskgcesvem tlrrnglgql gfhvnyegiv
      481 advepygyaw qaglrqgsrl veickvavat lsheqmidll rtsvtvkvvi ipphddctpr
      541 rscsetyrmp vmeykmnegv syefkfpfrn nnkwqrnask gphspqvpsq vqspmtsrln
      601 agkgdgkmpp peraaniprs issdgrpler rlspgsdiyv tvssmalars qcrnspsnls
      661 sssdtgsvgg tyrqksmpeg fgvsrrspas idrqntqsdi ggsgkstpsw qrsedsiadq
      721 meptchlpav skvlpafres psgrlmrqdp vvhlspnkqg hsdshysshs ssntlssnas
      781 sahsdekwyd gdrteselns ynylqgtsad sgidttsygp shgstaslga atssprsgpg
      841 kekvaplwhs ssevismadr tleteshgld rktesslsld ihsksqagst pltrenstfs
      901 indaashtst mssrhsaspv vftsarsspk eelhpaapsq lapsfsssss sssgprsfyp
      961 rqgatskyli gwkkpegtin svgfmdtrkr hqsdgneiah trlrastrdl raspkptsks
     1021 tieedlkkli dlesptpesq ksfkfhalss pqspfpstpt srralhrtls desiynsqre
     1081 hfftsrasll dqalpndvlf sstypslpks lplrrpsytl gmkslhgefs asdssltdiq
     1141 etrrqpmpdp glmplpdtaa dldwsnlvda akayevqras ffaasdenhr plsaasnsdq
     1201 ledqalaqmk pyssskdssp tlaskvdqle gmlkmlredl kkekedkahl qaevqhlred
     1261 nlrlqeesqn asdklkkfte wvfntidms
//
LOCUS       XP_047287208            1288 aa            linear   PRI 05-AUG-2025
DEFINITION  signal-induced proliferation-associated 1-like protein 1 isoform
            X10 [Homo sapiens].
ACCESSION   XP_047287208
VERSION     XP_047287208.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431252.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1288
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1288
                     /product="signal-induced proliferation-associated 1-like
                     protein 1 isoform X10"
                     /calculated_mol_wt=142984
     Region          135..315
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     Region          459..531
                     /region_name="PDZ_SIPA1-like"
                     /note="PDZ domain of signal-induced
                     proliferation-associated protein 1 (SIPA1), and related
                     domains; cd06745"
                     /db_xref="CDD:467227"
     Site            order(469..475,481,484,513,517,520..521)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467227"
     Region          989..1233
                     /region_name="SPAR_C"
                     /note="C-terminal domain of SPAR protein; pfam11881"
                     /db_xref="CDD:463383"
     Region          1221..1276
                     /region_name="ZapB"
                     /note="Cell division protein ZapB; pfam06005"
                     /db_xref="CDD:428718"
     CDS             1..1288
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /coded_by="XM_047431252.1:235..4101"
                     /db_xref="GeneID:26037"
                     /db_xref="HGNC:HGNC:20284"
                     /db_xref="MIM:617504"
ORIGIN      
        1 maqeykhwny fgadenlgpv avsirrekpd emkengspyn yriifrtsel mtlrgsvled
       61 aipstakhst arglplkevl ehvvpelnvq clrlafntpk vteqlmklde qglnyqqkvg
      121 imyckagqst eeemynnesa gpafeeflql lgervrlkgf ekyraqldtk tdstgthsly
      181 ttykdyeimf hvstmlpytp nnkqqllrkr higndivtiv fqepgaqpfs pknirshfqh
      241 vfvivrvhnp csdsvcysva vtrsrdvpsf gppipkgvtf pksnvfrdfl lakvinaena
      301 ahksekfram atrtrqeylk dlaeknvtnt pidpsgkfpf islaskkkek skpypgaels
      361 smgaivwavr aedynkamel dcllgisnef ivlieqetks vvfncscrdv igwtstdtsl
      421 kifyergecv svgsfiniee ikeivkrlqf vskgcesvem tlrrnglgql gfhvnyegiv
      481 advepygyaw qaglrqgsrl veickvavat lsheqmidll rtsvtvkvvi ipphddctpr
      541 rscsetyrmp vmeykmnegv syefkfpfrn nnkwqrnask gphspqvpsq vqspmtsrln
      601 agkgdgkmpp peraaniprs issdgrpler rlspgsdiyv tvssmalars qcrnspsnls
      661 sssdtgsvgg tyrqksmpeg fgvsrrspas idrqntqsdi ggsgkstpsw qrsedsiadq
      721 meptchlpav skvlpafres psgrlmrqdp vvhlspnkqg hsdshysshs ssntlssnas
      781 sahsdekwyd gdrteselns ynylqgtsad sgidttsygp shgstaslga atssprsgpg
      841 kekvaplwhs ssevismadr tleteshgld rktesslsld ihsksqagst pltrenstfs
      901 indaashtst mssrhsaspv vftsarsspk eelhpaapsq lapsfsssss sssgprsfyp
      961 rqgatskyli gwkkpegtin svgfmdtrkr hqsdgneiah trlrastrdl raspkptsks
     1021 tieedlkkli dlesptpesq ksfkfhalss pqspfpstpt srralhrtls desiynsqre
     1081 hfftsrasll dqalpndvlf sstypslpks lplrrpsytl gmkslhgefs asdssltdiq
     1141 etrrqpmpdp glmplpdtaa dldwsnlvda akayevqras ffaasdenhr plsaasnsdq
     1201 ledqalaqmk pysskdsspt laskvdqleg mlkmlredlk kekedkahlq aevqhlredn
     1261 lrlqeesqna sdklkkftew vfntidms
//
LOCUS       XP_047287209            1288 aa            linear   PRI 05-AUG-2025
DEFINITION  signal-induced proliferation-associated 1-like protein 1 isoform
            X10 [Homo sapiens].
ACCESSION   XP_047287209
VERSION     XP_047287209.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431253.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1288
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1288
                     /product="signal-induced proliferation-associated 1-like
                     protein 1 isoform X10"
                     /calculated_mol_wt=142984
     Region          135..315
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     Region          459..531
                     /region_name="PDZ_SIPA1-like"
                     /note="PDZ domain of signal-induced
                     proliferation-associated protein 1 (SIPA1), and related
                     domains; cd06745"
                     /db_xref="CDD:467227"
     Site            order(469..475,481,484,513,517,520..521)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467227"
     Region          989..1233
                     /region_name="SPAR_C"
                     /note="C-terminal domain of SPAR protein; pfam11881"
                     /db_xref="CDD:463383"
     Region          1221..1276
                     /region_name="ZapB"
                     /note="Cell division protein ZapB; pfam06005"
                     /db_xref="CDD:428718"
     CDS             1..1288
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /coded_by="XM_047431253.1:344..4210"
                     /db_xref="GeneID:26037"
                     /db_xref="HGNC:HGNC:20284"
                     /db_xref="MIM:617504"
ORIGIN      
        1 maqeykhwny fgadenlgpv avsirrekpd emkengspyn yriifrtsel mtlrgsvled
       61 aipstakhst arglplkevl ehvvpelnvq clrlafntpk vteqlmklde qglnyqqkvg
      121 imyckagqst eeemynnesa gpafeeflql lgervrlkgf ekyraqldtk tdstgthsly
      181 ttykdyeimf hvstmlpytp nnkqqllrkr higndivtiv fqepgaqpfs pknirshfqh
      241 vfvivrvhnp csdsvcysva vtrsrdvpsf gppipkgvtf pksnvfrdfl lakvinaena
      301 ahksekfram atrtrqeylk dlaeknvtnt pidpsgkfpf islaskkkek skpypgaels
      361 smgaivwavr aedynkamel dcllgisnef ivlieqetks vvfncscrdv igwtstdtsl
      421 kifyergecv svgsfiniee ikeivkrlqf vskgcesvem tlrrnglgql gfhvnyegiv
      481 advepygyaw qaglrqgsrl veickvavat lsheqmidll rtsvtvkvvi ipphddctpr
      541 rscsetyrmp vmeykmnegv syefkfpfrn nnkwqrnask gphspqvpsq vqspmtsrln
      601 agkgdgkmpp peraaniprs issdgrpler rlspgsdiyv tvssmalars qcrnspsnls
      661 sssdtgsvgg tyrqksmpeg fgvsrrspas idrqntqsdi ggsgkstpsw qrsedsiadq
      721 meptchlpav skvlpafres psgrlmrqdp vvhlspnkqg hsdshysshs ssntlssnas
      781 sahsdekwyd gdrteselns ynylqgtsad sgidttsygp shgstaslga atssprsgpg
      841 kekvaplwhs ssevismadr tleteshgld rktesslsld ihsksqagst pltrenstfs
      901 indaashtst mssrhsaspv vftsarsspk eelhpaapsq lapsfsssss sssgprsfyp
      961 rqgatskyli gwkkpegtin svgfmdtrkr hqsdgneiah trlrastrdl raspkptsks
     1021 tieedlkkli dlesptpesq ksfkfhalss pqspfpstpt srralhrtls desiynsqre
     1081 hfftsrasll dqalpndvlf sstypslpks lplrrpsytl gmkslhgefs asdssltdiq
     1141 etrrqpmpdp glmplpdtaa dldwsnlvda akayevqras ffaasdenhr plsaasnsdq
     1201 ledqalaqmk pysskdsspt laskvdqleg mlkmlredlk kekedkahlq aevqhlredn
     1261 lrlqeesqna sdklkkftew vfntidms
//
LOCUS       XP_011534940            1279 aa            linear   PRI 05-AUG-2025
DEFINITION  signal-induced proliferation-associated 1-like protein 1 isoform
            X11 [Homo sapiens].
ACCESSION   XP_011534940
VERSION     XP_011534940.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536638.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1279
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1279
                     /product="signal-induced proliferation-associated 1-like
                     protein 1 isoform X11"
                     /calculated_mol_wt=141972
     Region          104..284
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     Region          428..500
                     /region_name="PDZ_SIPA1-like"
                     /note="PDZ domain of signal-induced
                     proliferation-associated protein 1 (SIPA1), and related
                     domains; cd06745"
                     /db_xref="CDD:467227"
     Site            order(438..444,450,453,482,486,489..490)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467227"
     Region          979..1224
                     /region_name="SPAR_C"
                     /note="C-terminal domain of SPAR protein; pfam11881"
                     /db_xref="CDD:463383"
     Region          1212..1267
                     /region_name="ZapB"
                     /note="Cell division protein ZapB; pfam06005"
                     /db_xref="CDD:428718"
     CDS             1..1279
                     /gene="SIPA1L1"
                     /gene_synonym="E6TP1; SPAR1"
                     /coded_by="XM_011536638.3:179..4018"
                     /db_xref="GeneID:26037"
                     /db_xref="HGNC:HGNC:20284"
                     /db_xref="MIM:617504"
ORIGIN      
        1 mkengspyny riifrtselm tlrgsvleda ipstakhsta rglplkevle hvvpelnvqc
       61 lrlafntpkv teqlmkldeq glnyqqkvgi myckagqste eemynnesag pafeeflqll
      121 gervrlkgfe kyraqldtkt dstgthslyt tykdyeimfh vstmlpytpn nkqqllrkrh
      181 igndivtivf qepgaqpfsp knirshfqhv fvivrvhnpc sdsvcysvav trsrdvpsfg
      241 ppipkgvtfp ksnvfrdfll akvinaenaa hksekframa trtrqeylkd laeknvtntp
      301 idpsgkfpfi slaskkkeks kpypgaelss mgaivwavra edynkameld cllgisnefi
      361 vlieqetksv vfncscrdvi gwtstdtslk ifyergecvs vgsfinieei keivkrlqfv
      421 skgcesvemt lrrnglgqlg fhvnyegiva dvepygyawq aglrqgsrlv eickvavatl
      481 sheqmidllr tsvtvkvvii pphddctprr scsetyrmpv meykmnegvs yefkfpfrnn
      541 nkwqrnaskg phspqvpsqv qspmtsrlna gkgdgkmppp eraaniprsi ssdgrplerr
      601 lspgsdiyvt vssmalarsq crnspsnlss ssdtgsvggt yrqksmpegf gvsrrspasi
      661 drqntqsdig gsgkstpswq rsedsiadqm aysyrgpqdf nsfvleqhey teptchlpav
      721 skvlpafres psgrlmrqdp vvhlspnkqg hsdshysshs ssntlssnas sahsdekwyd
      781 gdrteselns ynylqgtsad sgidttsygp shgstaslga atssprsgpg kekvaplwhs
      841 ssevismadr tleteshgld rktesslsld ihsksqagst pltrenstfs indaashtst
      901 mssrhsaspv vftsarsspk eelhpaapsq lapsfsssss sssgprsfyp rqgatskyli
      961 gwkkpegtin svgfmdtrkr hqsdgneiah trlrastrdl raspkptsks tieedlkkli
     1021 dlesptpesq ksfkfhalss pqspfpstpt srralhrtls desiynsqre hfftsrasll
     1081 dqalpndvlf sstypslpks lplrrpsytl gmkslhgefs asdssltdiq etrrqpmpdp
     1141 glmplpdtaa dldwsnlvda akayevqras ffaasdenhr plsaasnsdq ledqalaqmk
     1201 pyssskdssp tlaskvdqle gmlkmlredl kkekedkahl qaevqhlred nlrlqeesqn
     1261 asdklkkfte wvfntidms
//
LOCUS       XP_047287210             520 aa            linear   PRI 05-AUG-2025
DEFINITION  DDB1- and CUL4-associated factor 4 isoform X1 [Homo sapiens].
ACCESSION   XP_047287210
VERSION     XP_047287210.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431254.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..520
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..520
                     /product="DDB1- and CUL4-associated factor 4 isoform X1"
                     /calculated_mol_wt=58416
     Region          310..>494
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          310..347
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          353..392
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          398..434
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          442..478
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..520
                     /gene="DCAF4"
                     /gene_synonym="WDR21; WDR21A"
                     /coded_by="XM_047431254.1:10..1572"
                     /db_xref="GeneID:26094"
                     /db_xref="HGNC:HGNC:20229"
                     /db_xref="MIM:616372"
ORIGIN      
        1 marssyeakp htsrimsryk lgtemnksrw qsrrrhgrrs hqqnpwfrlr dsedrsdsra
       61 aqpahdsghg ddespstssg tagtssvpel pgfyfdpekk ryfrllpghn ncnpltkesi
      121 rqkemeskrl rllqeedrrk kiarmgfnas smlrksqlgf lnvtnychla helrlscmer
      181 kkvqirsmdp salasdrfnl iladtnsdrl ftvndvkvgg skygiinlqs lktptlkvfm
      241 henlyftnrk vnsvcwasln hldshillcl mglaetpgca tllpaslfvn shpagidrpg
      301 mlcsfripga wscawslniq anncfstgls rrvlltnvvt ghrqsfgtns dvlaqqfalm
      361 apllfngcrs geifaidlrc gnqgkgwkat rlfhdsavts vrilqdeqyl masdmagkik
      421 lwdlrttkcv rqyeghvney aylplhvhee egilvavgqd cytriwslhd arllrtipsp
      481 ypaskadips vafssrlggs rgapgllmav gqdlycysys
//
LOCUS       XP_047287211             519 aa            linear   PRI 05-AUG-2025
DEFINITION  DDB1- and CUL4-associated factor 4 isoform X2 [Homo sapiens].
ACCESSION   XP_047287211
VERSION     XP_047287211.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431255.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..519
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..519
                     /product="DDB1- and CUL4-associated factor 4 isoform X2"
                     /calculated_mol_wt=58345
     Region          309..>493
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          309..346
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          352..391
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          397..433
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          441..477
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..519
                     /gene="DCAF4"
                     /gene_synonym="WDR21; WDR21A"
                     /coded_by="XM_047431255.1:10..1569"
                     /db_xref="GeneID:26094"
                     /db_xref="HGNC:HGNC:20229"
                     /db_xref="MIM:616372"
ORIGIN      
        1 marssyeakp htsrimsryk lgtemnksrw qsrrrhgrrs hqqnpwfrlr dsedrsdsra
       61 aqpahdsghg ddespstssg tagtssvpel pgfyfdpekk ryfrllpghn ncnpltkesi
      121 rqkemeskrl rllqeedrrk kiarmgfnas smlrksqlgf lnvtnychla helrlscmer
      181 kkvqirsmdp salasdrfnl iladtnsdrl ftvndvkvgg skygiinlqs lktptlkvfm
      241 henlyftnrk vnsvcwasln hldshillcl mglaetpgca tllpaslfvn shpgidrpgm
      301 lcsfripgaw scawslniqa nncfstglsr rvlltnvvtg hrqsfgtnsd vlaqqfalma
      361 pllfngcrsg eifaidlrcg nqgkgwkatr lfhdsavtsv rilqdeqylm asdmagkikl
      421 wdlrttkcvr qyeghvneya ylplhvheee gilvavgqdc ytriwslhda rllrtipspy
      481 paskadipsv afssrlggsr gapgllmavg qdlycysys
//
LOCUS       XP_047287212             500 aa            linear   PRI 05-AUG-2025
DEFINITION  DDB1- and CUL4-associated factor 4 isoform X3 [Homo sapiens].
ACCESSION   XP_047287212
VERSION     XP_047287212.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431256.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..500
                     /product="DDB1- and CUL4-associated factor 4 isoform X3"
                     /calculated_mol_wt=56765
     Region          310..347
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          <340..459
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          353..392
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          398..434
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..500
                     /gene="DCAF4"
                     /gene_synonym="WDR21; WDR21A"
                     /coded_by="XM_047431256.1:10..1512"
                     /db_xref="GeneID:26094"
                     /db_xref="HGNC:HGNC:20229"
                     /db_xref="MIM:616372"
ORIGIN      
        1 marssyeakp htsrimsryk lgtemnksrw qsrrrhgrrs hqqnpwfrlr dsedrsdsra
       61 aqpahdsghg ddespstssg tagtssvpel pgfyfdpekk ryfrllpghn ncnpltkesi
      121 rqkemeskrl rllqeedrrk kiarmgfnas smlrksqlgf lnvtnychla helrlscmer
      181 kkvqirsmdp salasdrfnl iladtnsdrl ftvndvkvgg skygiinlqs lktptlkvfm
      241 henlyftnrk vnsvcwasln hldshillcl mglaetpgca tllpaslfvn shpagidrpg
      301 mlcsfripga wscawslniq anncfstgls rrvlltnvvt ghrqsfgtns dvlaqqfalm
      361 apllfngcrs geifaidlrc gnqgkgwkat rlfhdsavts vrilqdeqyl masdmagkik
      421 lwdlrttkcv rqyeghvney aylplhvhee egilvagsww hrkgwldsrm hpphlqerte
      481 ipqqeklgrd rqvlppfpas
//
LOCUS       XP_047287213             499 aa            linear   PRI 05-AUG-2025
DEFINITION  DDB1- and CUL4-associated factor 4 isoform X4 [Homo sapiens].
ACCESSION   XP_047287213
VERSION     XP_047287213.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431257.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..499
                     /product="DDB1- and CUL4-associated factor 4 isoform X4"
                     /calculated_mol_wt=56694
     Region          309..346
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          <339..458
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          352..391
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          397..433
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..499
                     /gene="DCAF4"
                     /gene_synonym="WDR21; WDR21A"
                     /coded_by="XM_047431257.1:10..1509"
                     /db_xref="GeneID:26094"
                     /db_xref="HGNC:HGNC:20229"
                     /db_xref="MIM:616372"
ORIGIN      
        1 marssyeakp htsrimsryk lgtemnksrw qsrrrhgrrs hqqnpwfrlr dsedrsdsra
       61 aqpahdsghg ddespstssg tagtssvpel pgfyfdpekk ryfrllpghn ncnpltkesi
      121 rqkemeskrl rllqeedrrk kiarmgfnas smlrksqlgf lnvtnychla helrlscmer
      181 kkvqirsmdp salasdrfnl iladtnsdrl ftvndvkvgg skygiinlqs lktptlkvfm
      241 henlyftnrk vnsvcwasln hldshillcl mglaetpgca tllpaslfvn shpgidrpgm
      301 lcsfripgaw scawslniqa nncfstglsr rvlltnvvtg hrqsfgtnsd vlaqqfalma
      361 pllfngcrsg eifaidlrcg nqgkgwkatr lfhdsavtsv rilqdeqylm asdmagkikl
      421 wdlrttkcvr qyeghvneya ylplhvheee gilvagswwh rkgwldsrmh pphlqertei
      481 pqqeklgrdr qvlppfpas
//
LOCUS       XP_016876694             496 aa            linear   PRI 05-AUG-2025
DEFINITION  DDB1- and CUL4-associated factor 4 isoform X5 [Homo sapiens].
ACCESSION   XP_016876694
VERSION     XP_016876694.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021205.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..496
                     /product="DDB1- and CUL4-associated factor 4 isoform X5"
                     /calculated_mol_wt=55634
     Region          286..>470
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          286..323
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          329..368
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          374..410
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          418..454
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..496
                     /gene="DCAF4"
                     /gene_synonym="WDR21; WDR21A"
                     /coded_by="XM_017021205.2:332..1822"
                     /db_xref="GeneID:26094"
                     /db_xref="HGNC:HGNC:20229"
                     /db_xref="MIM:616372"
ORIGIN      
        1 mnksrwqsrr rhgrrshqqn pwfrlrdsed rsdsraaqpa hdsghgddes pstssgtagt
       61 ssvpelpgfy fdpekkryfr llpghnncnp ltkesirqke meskrlrllq eedrrkkiar
      121 mgfnassmlr ksqlgflnvt nychlahelr lscmerkkvq irsmdpsala sdrfnlilad
      181 tnsdrlftvn dvkvggskyg iinlqslktp tlkvfmhenl yftnrkvnsv cwaslnhlds
      241 hillclmgla etpgcatllp aslfvnshpa gidrpgmlcs fripgawsca wslniqannc
      301 fstglsrrvl ltnvvtghrq sfgtnsdvla qqfalmapll fngcrsgeif aidlrcgnqg
      361 kgwkatrlfh dsavtsvril qdeqylmasd magkiklwdl rttkcvrqye ghvneyaylp
      421 lhvheeegil vavgqdcytr iwslhdarll rtipspypas kadipsvafs srlggsrgap
      481 gllmavgqdl ycysys
//
LOCUS       XP_016876695             496 aa            linear   PRI 05-AUG-2025
DEFINITION  DDB1- and CUL4-associated factor 4 isoform X5 [Homo sapiens].
ACCESSION   XP_016876695
VERSION     XP_016876695.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021206.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..496
                     /product="DDB1- and CUL4-associated factor 4 isoform X5"
                     /calculated_mol_wt=55634
     Region          286..>470
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          286..323
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          329..368
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          374..410
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          418..454
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..496
                     /gene="DCAF4"
                     /gene_synonym="WDR21; WDR21A"
                     /coded_by="XM_017021206.2:168..1658"
                     /db_xref="GeneID:26094"
                     /db_xref="HGNC:HGNC:20229"
                     /db_xref="MIM:616372"
ORIGIN      
        1 mnksrwqsrr rhgrrshqqn pwfrlrdsed rsdsraaqpa hdsghgddes pstssgtagt
       61 ssvpelpgfy fdpekkryfr llpghnncnp ltkesirqke meskrlrllq eedrrkkiar
      121 mgfnassmlr ksqlgflnvt nychlahelr lscmerkkvq irsmdpsala sdrfnlilad
      181 tnsdrlftvn dvkvggskyg iinlqslktp tlkvfmhenl yftnrkvnsv cwaslnhlds
      241 hillclmgla etpgcatllp aslfvnshpa gidrpgmlcs fripgawsca wslniqannc
      301 fstglsrrvl ltnvvtghrq sfgtnsdvla qqfalmapll fngcrsgeif aidlrcgnqg
      361 kgwkatrlfh dsavtsvril qdeqylmasd magkiklwdl rttkcvrqye ghvneyaylp
      421 lhvheeegil vavgqdcytr iwslhdarll rtipspypas kadipsvafs srlggsrgap
      481 gllmavgqdl ycysys
//
LOCUS       XP_047287214             474 aa            linear   PRI 05-AUG-2025
DEFINITION  DDB1- and CUL4-associated factor 4 isoform X6 [Homo sapiens].
ACCESSION   XP_047287214
VERSION     XP_047287214.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431258.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..474
                     /product="DDB1- and CUL4-associated factor 4 isoform X6"
                     /calculated_mol_wt=52665
     Region          264..>448
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          264..301
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          307..346
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          352..388
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          396..432
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..474
                     /gene="DCAF4"
                     /gene_synonym="WDR21; WDR21A"
                     /coded_by="XM_047431258.1:207..1631"
                     /db_xref="GeneID:26094"
                     /db_xref="HGNC:HGNC:20229"
                     /db_xref="MIM:616372"
ORIGIN      
        1 mgeeatsrtl gsdsvilktg ltpgqhsplt ipatvmtslr qprlaqlgpp lcqkryfrll
       61 pghnncnplt kesirqkeme skrlrllqee drrkkiarmg fnassmlrks qlgflnvtny
      121 chlahelrls cmerkkvqir smdpsalasd rfnliladtn sdrlftvndv kvggskygii
      181 nlqslktptl kvfmhenlyf tnrkvnsvcw aslnhldshi llclmglaet pgcatllpas
      241 lfvnshpagi drpgmlcsfr ipgawscaws lniqanncfs tglsrrvllt nvvtghrqsf
      301 gtnsdvlaqq falmapllfn gcrsgeifai dlrcgnqgkg wkatrlfhds avtsvrilqd
      361 eqylmasdma gkiklwdlrt tkcvrqyegh vneyaylplh vheeegilva vgqdcytriw
      421 slhdarllrt ipspypaska dipsvafssr lggsrgapgl lmavgqdlyc ysys
//
LOCUS       XP_016876702             474 aa            linear   PRI 05-AUG-2025
DEFINITION  DDB1- and CUL4-associated factor 4 isoform X6 [Homo sapiens].
ACCESSION   XP_016876702
VERSION     XP_016876702.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021213.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..474
                     /product="DDB1- and CUL4-associated factor 4 isoform X6"
                     /calculated_mol_wt=52665
     Region          264..>448
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          264..301
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          307..346
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          352..388
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          396..432
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..474
                     /gene="DCAF4"
                     /gene_synonym="WDR21; WDR21A"
                     /coded_by="XM_017021213.3:202..1626"
                     /db_xref="GeneID:26094"
                     /db_xref="HGNC:HGNC:20229"
                     /db_xref="MIM:616372"
ORIGIN      
        1 mgeeatsrtl gsdsvilktg ltpgqhsplt ipatvmtslr qprlaqlgpp lcqkryfrll
       61 pghnncnplt kesirqkeme skrlrllqee drrkkiarmg fnassmlrks qlgflnvtny
      121 chlahelrls cmerkkvqir smdpsalasd rfnliladtn sdrlftvndv kvggskygii
      181 nlqslktptl kvfmhenlyf tnrkvnsvcw aslnhldshi llclmglaet pgcatllpas
      241 lfvnshpagi drpgmlcsfr ipgawscaws lniqanncfs tglsrrvllt nvvtghrqsf
      301 gtnsdvlaqq falmapllfn gcrsgeifai dlrcgnqgkg wkatrlfhds avtsvrilqd
      361 eqylmasdma gkiklwdlrt tkcvrqyegh vneyaylplh vheeegilva vgqdcytriw
      421 slhdarllrt ipspypaska dipsvafssr lggsrgapgl lmavgqdlyc ysys
//
LOCUS       XP_047287215             474 aa            linear   PRI 05-AUG-2025
DEFINITION  DDB1- and CUL4-associated factor 4 isoform X6 [Homo sapiens].
ACCESSION   XP_047287215
VERSION     XP_047287215.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431259.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..474
                     /product="DDB1- and CUL4-associated factor 4 isoform X6"
                     /calculated_mol_wt=52665
     Region          264..>448
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          264..301
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          307..346
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          352..388
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          396..432
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..474
                     /gene="DCAF4"
                     /gene_synonym="WDR21; WDR21A"
                     /coded_by="XM_047431259.1:116..1540"
                     /db_xref="GeneID:26094"
                     /db_xref="HGNC:HGNC:20229"
                     /db_xref="MIM:616372"
ORIGIN      
        1 mgeeatsrtl gsdsvilktg ltpgqhsplt ipatvmtslr qprlaqlgpp lcqkryfrll
       61 pghnncnplt kesirqkeme skrlrllqee drrkkiarmg fnassmlrks qlgflnvtny
      121 chlahelrls cmerkkvqir smdpsalasd rfnliladtn sdrlftvndv kvggskygii
      181 nlqslktptl kvfmhenlyf tnrkvnsvcw aslnhldshi llclmglaet pgcatllpas
      241 lfvnshpagi drpgmlcsfr ipgawscaws lniqanncfs tglsrrvllt nvvtghrqsf
      301 gtnsdvlaqq falmapllfn gcrsgeifai dlrcgnqgkg wkatrlfhds avtsvrilqd
      361 eqylmasdma gkiklwdlrt tkcvrqyegh vneyaylplh vheeegilva vgqdcytriw
      421 slhdarllrt ipspypaska dipsvafssr lggsrgapgl lmavgqdlyc ysys
//
LOCUS       XP_047287216             473 aa            linear   PRI 05-AUG-2025
DEFINITION  DDB1- and CUL4-associated factor 4 isoform X7 [Homo sapiens].
ACCESSION   XP_047287216
VERSION     XP_047287216.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431260.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..473
                     /product="DDB1- and CUL4-associated factor 4 isoform X7"
                     /calculated_mol_wt=52594
     Region          263..>447
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          263..300
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          306..345
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          351..387
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          395..431
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..473
                     /gene="DCAF4"
                     /gene_synonym="WDR21; WDR21A"
                     /coded_by="XM_047431260.1:207..1628"
                     /db_xref="GeneID:26094"
                     /db_xref="HGNC:HGNC:20229"
                     /db_xref="MIM:616372"
ORIGIN      
        1 mgeeatsrtl gsdsvilktg ltpgqhsplt ipatvmtslr qprlaqlgpp lcqkryfrll
       61 pghnncnplt kesirqkeme skrlrllqee drrkkiarmg fnassmlrks qlgflnvtny
      121 chlahelrls cmerkkvqir smdpsalasd rfnliladtn sdrlftvndv kvggskygii
      181 nlqslktptl kvfmhenlyf tnrkvnsvcw aslnhldshi llclmglaet pgcatllpas
      241 lfvnshpgid rpgmlcsfri pgawscawsl niqanncfst glsrrvlltn vvtghrqsfg
      301 tnsdvlaqqf almapllfng crsgeifaid lrcgnqgkgw katrlfhdsa vtsvrilqde
      361 qylmasdmag kiklwdlrtt kcvrqyeghv neyaylplhv heeegilvav gqdcytriws
      421 lhdarllrti pspypaskad ipsvafssrl ggsrgapgll mavgqdlycy sys
//
LOCUS       XP_011534943            1573 aa            linear   PRI 05-AUG-2025
DEFINITION  kinesin-like protein KIF26A isoform X1 [Homo sapiens].
ACCESSION   XP_011534943
VERSION     XP_011534943.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536641.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1573
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1573
                     /product="kinesin-like protein KIF26A isoform X1"
                     /calculated_mol_wt=163372
     Region          62..414
                     /region_name="KISc"
                     /note="Kinesin motor domain; cd00106"
                     /db_xref="CDD:276812"
     Site            order(68,70..71,160..168,325)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276812"
     Site            order(368,371,374)
                     /site_type="other"
                     /note="microtubule interaction site [polypeptide binding]"
                     /db_xref="CDD:276812"
     Region          <535..969
                     /region_name="PRK07764"
                     /note="DNA polymerase III subunits gamma and tau;
                     Validated"
                     /db_xref="CDD:236090"
     Region          1065..>1404
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     CDS             1..1573
                     /gene="KIF26A"
                     /gene_synonym="CDCBM11"
                     /coded_by="XM_011536641.3:73..4794"
                     /db_xref="GeneID:26153"
                     /db_xref="HGNC:HGNC:20226"
                     /db_xref="MIM:613231"
ORIGIN      
        1 mqklslaskr kkphpppppa trgtstyptd fsgvlqlwpp pappcllraa sktkdnpgsi
       61 gkvkvmlriw paqgaqrsae amsflkvdpr kkqvilydpa agppgsagpr raataavpkm
      121 fafdavfpqd seqaevcsgt vadvlqsvvs gadgcifsfg hmslgksytm igkdsspqsl
      181 givpcaiswl frlieerrer tgtrfsvrvs avevcgrdqs lrdllaevap gslqdtqspg
      241 vylredpvcg aqlqnqselr aptaekaafy ldaalaarst sragcgedar rsshmlftlh
      301 vyqyrmekcg rggmsggrsr lhlidlgsce aaagrageaa ggplclslsa lgsvilalvn
      361 gakhvpyrdh rltmllresl atagcrttmi ahvsdapaqh aetlstvqla arihrlrrkk
      421 akyassssgg essceegrar rpphlrpfhp rtvaldpdrt ppclpgdpdy sssseqscdt
      481 viyvgpggaa lsdreltdne gppdfvpiip alsrhrpskg prdadhfrcs tfaelqerle
      541 cmdgnegpsg gpggtdgaqa sparggrkps ppeaasprka vgtpmaastp rgssgpdthq
      601 gtpepckaiv wgdqredssa wpellvpeka avsggrrplp spappppqll eacrapeepg
      661 gggtdgvart ppvgmsgqva gspmlpgatc prlaagsrcp erglltttvt lqrpvelnge
      721 delvftvvee lslgalagag rptslasfds dcslralasg srpvsiissi ndefdaytsq
      781 apeggplega awagsshgss isswlsevsv ctadsrdptp qprfspdsla gldpggppal
      841 dgslgdgssg flgpdrpdsp gptwgpcpge vaavapsrpg repqagpsrw asaaqtihss
      901 lprkprtasa ttrvgcarlg qsppgrgglf edpwllrvge cdtqaasagr apsptlgspr
      961 lpeaqvmlac aqrvvdgcev aaraarrpea varipplrrg attlgvttpa vswgdaptev
     1021 vacsgslkas ptskkglapk agflprpsga appapptrks sleqrsspas apphavnpar
     1081 vgaaavlrge eeprpssrad hsvpratssl karaskveaa hrlaghasle ryeglahsss
     1141 kgreapgrpp ravpklgvpp sspthgpapa crsgaakavg apkppvgggk grglvaggsr
     1201 algpsvklst asvtgrspgg pvagpraapr agpsvgakag rgtvmgtkqa lraahsrvhe
     1261 lsasgapgrg gsswgsadsd sghdsgvnvg eerpptgpal pspyskvtap rrpqryssgh
     1321 gsdnssvlsg elppamgrta lfhhsggssg yeslrrdsea tgsassapds msesgaaspg
     1381 artrslkspk kratglqrrr lipaplpdtt algrkpslpg qwvdlpppla gslkepfeik
     1441 vyeiddverl qrprptprea ptqglacvst rlrlaerrqq rlrevqakhk hlceelaetq
     1501 grlmlepgrw leqfevdpel epesaeylaa lerataaleq cvnlckahvm mvtcfdisva
     1561 asaaipgpqe vdv
//
LOCUS       XP_016876706             237 aa            linear   PRI 05-AUG-2025
DEFINITION  TERF1-interacting nuclear factor 2 isoform X1 [Homo sapiens].
ACCESSION   XP_016876706
VERSION     XP_016876706.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021217.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..237
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..237
                     /product="TERF1-interacting nuclear factor 2 isoform X1"
                     /calculated_mol_wt=25799
     Region          35..139
                     /region_name="TIN2_TBM"
                     /note="TRF-binding motif region of TRF-Interacting Nuclear
                     factor 2; cd11741"
                     /db_xref="CDD:240666"
     CDS             1..237
                     /gene="TINF2"
                     /gene_synonym="DKCA3; DKCA5; TIN2"
                     /coded_by="XM_017021217.2:118..831"
                     /db_xref="GeneID:26277"
                     /db_xref="HGNC:HGNC:11824"
                     /db_xref="MIM:604319"
ORIGIN      
        1 meqnppqqqr lalhnplpka kpgthlpqgp ssrthpepla grhfnlaplg rrrvqsqwas
       61 trgghkerpt vmlfpfrnlg sptqviskpe skeehaiyta dlamgtraas tgkskspcqt
      121 lggralkenp vdlpateqke ncldcymdpl rlsllpprar kpvcppslcs svitigdlvl
      181 dsdeeengqg egkeslenyq ktkfdtlipt lceylppsgh gaipvsscdc rdssrpl
//
LOCUS       XP_011534944             180 aa            linear   PRI 05-AUG-2025
DEFINITION  TERF1-interacting nuclear factor 2 isoform X2 [Homo sapiens].
ACCESSION   XP_011534944
VERSION     XP_011534944.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536642.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..180
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..180
                     /product="TERF1-interacting nuclear factor 2 isoform X2"
                     /calculated_mol_wt=20208
     Region          20..169
                     /region_name="TINF2_N"
                     /note="TERF1-interacting nuclear factor 2 N-terminus;
                     pfam14973"
                     /db_xref="CDD:464415"
     CDS             1..180
                     /gene="TINF2"
                     /gene_synonym="DKCA3; DKCA5; TIN2"
                     /coded_by="XM_011536642.3:343..885"
                     /db_xref="GeneID:26277"
                     /db_xref="HGNC:HGNC:11824"
                     /db_xref="MIM:604319"
ORIGIN      
        1 matplvagpa alrfaaaasw qvvrgrcveh fprvleflrs lravapglvr yrhherlcmg
       61 lkakvvveli lqgrpwaqvl kalnhhfpes gpivrdpkat kqdlrkilea qetfyqqvkq
      121 lseapvdlas klqeleqeyg epflaamekl lfeylcqlek alptpqaqqv slgqnivlcy
//
LOCUS       XP_047287217             172 aa            linear   PRI 05-AUG-2025
DEFINITION  GTP cyclohydrolase 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047287217
VERSION     XP_047287217.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431261.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..172
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..172
                     /product="GTP cyclohydrolase 1 isoform X1"
                     /calculated_mol_wt=18968
     Region          66..>170
                     /region_name="TFold"
                     /note="Tunnelling fold (T-fold). The five known T-folds
                     are found in five different enzymes with different
                     functions: dihydroneopterin-triphosphate epimerase
                     (DHNTPE), dihydroneopterin aldolase (DHNA), GTP
                     cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; cl00263"
                     /db_xref="CDD:469697"
     CDS             1..172
                     /gene="GCH1"
                     /gene_synonym="DYT14; DYT5; DYT5a; GCH; GTP-CH-1; GTPCH1;
                     HPABH4B"
                     /coded_by="XM_047431261.1:164..682"
                     /db_xref="GeneID:2643"
                     /db_xref="HGNC:HGNC:4193"
                     /db_xref="MIM:600225"
ORIGIN      
        1 mekgpvrapa ekprgarcsn gfperdpprp gpsrpaekpp rpeaksaqpa dgwkgerprs
       61 eednelnlpn laaayssils slgenpqrqg llktpwraas amqfftkgyq etisdvlnda
      121 ifdedhdemv ivkdidmfsm cehhlvpfvg kvhigylpnk qvlglsklar nn
//
LOCUS       XP_047287218             319 aa            linear   PRI 05-AUG-2025
DEFINITION  pleckstrin-2 isoform X1 [Homo sapiens].
ACCESSION   XP_047287218
VERSION     XP_047287218.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431262.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..319
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..319
                     /product="pleckstrin-2 isoform X1"
                     /calculated_mol_wt=36118
     Region          3..113
                     /region_name="PH1_Pleckstrin_2"
                     /note="Pleckstrin 2 Pleckstrin homology (PH) domain,
                     repeat 1; cd13301"
                     /db_xref="CDD:270113"
     Region          128..228
                     /region_name="DEP_PLEK2"
                     /note="DEP (Dishevelled, Egl-10, and Pleckstrin) domain
                     found in pleckstrin 2-like proteins. Pleckstrin 2 is found
                     in a wide variety of cell types, which suggest a more
                     general role in signaling than pleckstrin 1.
                     Pleckstrin-like proteins contain a central...; cd04444"
                     /db_xref="CDD:239891"
     Region          224..319
                     /region_name="PH-like"
                     /note="Pleckstrin homology-like domain; cl17171"
                     /db_xref="CDD:473070"
     CDS             1..319
                     /gene="PLEK2"
                     /coded_by="XM_047431262.1:107..1066"
                     /db_xref="GeneID:26499"
                     /db_xref="HGNC:HGNC:19238"
                     /db_xref="MIM:608007"
ORIGIN      
        1 medgvlkegf lvkrghivhn wkarwfilrq ntlvyykleg grrvtppkgr illdgctitc
       61 pcleyenrpl liklktqtst eyfleacsre erdawafeit gaihagqpgk vqqlhslrns
      121 fklpphislh rivdkmhdsn tgirsspnme qgstykktfl gsslvdwlis nsftasrlea
      181 vtlasmlmee nflrpvgvrs mgairsgdla eqflddstal ytfghkrknw kvrrfvlrkd
      241 paflhyydps keenrpvggf slrgslvsal edngvptgvk gnvqgnlfkv itkddthyyi
      301 qasskaerae wieaikklt
//
LOCUS       XP_047287219             218 aa            linear   PRI 05-AUG-2025
DEFINITION  pleckstrin-2 isoform X2 [Homo sapiens].
ACCESSION   XP_047287219
VERSION     XP_047287219.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431263.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 8% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..218
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..218
                     /product="pleckstrin-2 isoform X2"
                     /calculated_mol_wt=24234
     Region          1..101
                     /region_name="DEP_PLEK2"
                     /note="DEP (Dishevelled, Egl-10, and Pleckstrin) domain
                     found in pleckstrin 2-like proteins. Pleckstrin 2 is found
                     in a wide variety of cell types, which suggest a more
                     general role in signaling than pleckstrin 1.
                     Pleckstrin-like proteins contain a central...; cd04444"
                     /db_xref="CDD:239891"
     Region          107..218
                     /region_name="PH2_Pleckstrin_2"
                     /note="Pleckstrin 2 Pleckstrin homology (PH) domain,
                     repeat 2; cd13302"
                     /db_xref="CDD:270114"
     Site            order(120,122..125,145,156,197)
                     /site_type="other"
                     /note="phosphoinositide binding site [chemical binding]"
                     /db_xref="CDD:270114"
     Site            order(140,142,144,155,158,160,162..163,192)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:270114"
     CDS             1..218
                     /gene="PLEK2"
                     /coded_by="XM_047431263.1:561..1217"
                     /db_xref="GeneID:26499"
                     /db_xref="HGNC:HGNC:19238"
                     /db_xref="MIM:608007"
ORIGIN      
        1 mhdsntgirs spnmeqgsty kktflgsslv dwlisnsfta srleavtlas mlmeenflrp
       61 vgvrsmgair sgdlaeqfld dstalytfae sykkkispke eislstvels gtvvkqgyla
      121 kqghkrknwk vrrfvlrkdp aflhyydpsk eenrpvggfs lrgslvsale dngvptgvkg
      181 nvqgnlfkvi tkddthyyiq asskaeraew ieaikklt
//
LOCUS       XP_047287220              89 aa            linear   PRI 05-AUG-2025
DEFINITION  mitochondrial import inner membrane translocase subunit Tim9
            isoform X1 [Homo sapiens].
ACCESSION   XP_047287220
VERSION     XP_047287220.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431264.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..89
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..89
                     /product="mitochondrial import inner membrane translocase
                     subunit Tim9 isoform X1"
                     /calculated_mol_wt=10247
     Region          10..69
                     /region_name="zf-Tim10_DDP"
                     /note="Tim10/DDP family zinc finger; pfam02953"
                     /db_xref="CDD:460764"
     CDS             1..89
                     /gene="TIMM9"
                     /gene_synonym="TIM9; TIM9A"
                     /coded_by="XM_047431264.1:356..625"
                     /db_xref="GeneID:26520"
                     /db_xref="HGNC:HGNC:11819"
                     /db_xref="MIM:607384"
ORIGIN      
        1 maaqipesdq ikqfkeflgt ynkltetcfl dcvkdfttre vkpeettcse hclqkylkmt
       61 qrismrfqey hiqqnealaa kagllgqpr
//
LOCUS       XP_006720179            1453 aa            linear   PRI 05-AUG-2025
DEFINITION  DNA mismatch repair protein Mlh3 isoform X1 [Homo sapiens].
ACCESSION   XP_006720179
VERSION     XP_006720179.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720116.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1453
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1453
                     /product="DNA mismatch repair protein Mlh3 isoform X1"
                     /calculated_mol_wt=163581
     Region          9..192
                     /region_name="HATPase_MutL-MLH-PMS-like"
                     /note="Histidine kinase-like ATPase domain of DNA mismatch
                     repair proteins Escherichia coli MutL, human MutL homologs
                     (MLH/ PMS), and related domains; cd16926"
                     /db_xref="CDD:340403"
     Site            order(28,32..33,35..36,54,56,58,60..61,69,74..77,94..97,
                     109,111,143..144,146)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:340403"
     Site            order(70,97)
                     /site_type="other"
                     /note="ATP-lid"
                     /db_xref="CDD:340403"
     Region          206..349
                     /region_name="MutL_Trans_MLH3"
                     /note="transducer domain, having a ribosomal S5 domain
                     2-like fold, found in proteins similar to yeast and human
                     MLH3 (MutL homologue 3). MLH3 belongs to the DNA mismatch
                     repair (MutL/MLH1/PMS2) family. This transducer domain is
                     homologous to the second domain...; cd03486"
                     /db_xref="CDD:239568"
     Site            325
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:239568"
     Region          <1194..1409
                     /region_name="MutL"
                     /note="DNA mismatch repair ATPase MutL [Replication,
                     recombination and repair]; COG0323"
                     /db_xref="CDD:440092"
     CDS             1..1453
                     /gene="MLH3"
                     /gene_synonym="HNPCC7"
                     /coded_by="XM_006720116.5:93..4454"
                     /db_xref="GeneID:27030"
                     /db_xref="HGNC:HGNC:7128"
                     /db_xref="MIM:604395"
ORIGIN      
        1 mikclsvevq aklrsglais slgqcveela lnsidaeakc vavrvnmetf qvqvidngfg
       61 mgsddvekvg nryftskchs vqdlenprfy gfrgealani admasaveis skknrtmktf
      121 vklfqsgkal kaceadvtra sagttvtvyn lfyqlpvrrk cmdprlefek vrqriealsl
      181 mhpsisfslr ndvsgsmvlq lpktkdvcsr fcqiyglgks qklreisfky kefelsgyis
      241 seahynknmq flfvnkrlvl rtklhklidf llrkesiick pkngptsrqm nsslrhrstp
      301 elygiyvinv qcqfceydvc mepaktlief qnwdtllfci qegvkmflkq eklfvelsge
      361 dikefsedng fslfdatlqk rvtsdersnf qeacnnilds yemfnlqska vkrkttaenv
      421 ntqssrdsea trkntndafl yiyesggpgh skmtepslqn kdsscseskm leqetivase
      481 agenekhkks flehsslenp cgtslemfls pfqtpchfee sgqdleiwke sttvngmaan
      541 ilknnriqnq pkrfkdatev gcqplpfatt lwgvhsaqte kekkkessnc grrnvfsygr
      601 vklcstgfit hvvqnektks tetehsfkny vrpgptraqe tfgnrtrhsv etpdikdlas
      661 tlskesgqlp nkkncrtnis ygleneptat ytmfsafqeg skksqtdcil sdtspsfpwy
      721 rhvsndsrkt dkligfskpi vrkklslssq lgslekfkrq ygkvenpldt eveesngvtt
      781 nlslqvepdi llkdknrlen sdvckittme hsdsdsscqp ashilnsekf pfskdedcle
      841 qqmpslresp mtlkelslfn rkpldlekss eslasklsrl kgseretqtm gmmsrfnelp
      901 nsdssrkdsk lcsvltqdfc mlfnnkhekt engviptsds atqdnsfnkn skthsnsntt
      961 encvisetpl vlpynnskvt gkdsdvlira seqqigslds psgmlmnpve datgdqngic
     1021 fqseeskara cseteesntc csdwqrhfdv algrmvyvnk mtglstfiap tediqaactk
     1081 dlttvavdvv lengsqyrcq pfrsdlvlpf lpraraertv mrqdnrdtvd dtvsseslqs
     1141 lfsewdnpvf arypevavdv ssgqaeslav kihnilypyr ftkgmihsmq vlqqvdnkfi
     1201 aclmstktee ngeaggnllv lvdqhaaher irleqliids yekqqaqgsg rkkllsstli
     1261 ppleitvtee qrrllwcyhk nledlglefv fpdtsdslvl vgkvplcfve reanelrrgr
     1321 stvtksivee fireqlellq ttggiqgtlp ltvqkvlasq achgaikfnd glslqescrl
     1381 iealsscqlp fqcahgrpsm lpladidhle qekqikpnlt klrkmaqawr lfgkaecdtr
     1441 qslqqsmppc epp
//
LOCUS       XP_016876708            1429 aa            linear   PRI 05-AUG-2025
DEFINITION  DNA mismatch repair protein Mlh3 isoform X2 [Homo sapiens].
ACCESSION   XP_016876708
VERSION     XP_016876708.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021219.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1429
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1429
                     /product="DNA mismatch repair protein Mlh3 isoform X2"
                     /calculated_mol_wt=160891
     Region          9..192
                     /region_name="HATPase_MutL-MLH-PMS-like"
                     /note="Histidine kinase-like ATPase domain of DNA mismatch
                     repair proteins Escherichia coli MutL, human MutL homologs
                     (MLH/ PMS), and related domains; cd16926"
                     /db_xref="CDD:340403"
     Site            order(28,32..33,35..36,54,56,58,60..61,69,74..77,94..97,
                     109,111,143..144,146)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:340403"
     Site            order(70,97)
                     /site_type="other"
                     /note="ATP-lid"
                     /db_xref="CDD:340403"
     Region          206..349
                     /region_name="MutL_Trans_MLH3"
                     /note="transducer domain, having a ribosomal S5 domain
                     2-like fold, found in proteins similar to yeast and human
                     MLH3 (MutL homologue 3). MLH3 belongs to the DNA mismatch
                     repair (MutL/MLH1/PMS2) family. This transducer domain is
                     homologous to the second domain...; cd03486"
                     /db_xref="CDD:239568"
     Site            325
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:239568"
     Region          <1217..1385
                     /region_name="MutL"
                     /note="DNA mismatch repair ATPase MutL [Replication,
                     recombination and repair]; COG0323"
                     /db_xref="CDD:440092"
     CDS             1..1429
                     /gene="MLH3"
                     /gene_synonym="HNPCC7"
                     /coded_by="XM_017021219.3:93..4382"
                     /db_xref="GeneID:27030"
                     /db_xref="HGNC:HGNC:7128"
                     /db_xref="MIM:604395"
ORIGIN      
        1 mikclsvevq aklrsglais slgqcveela lnsidaeakc vavrvnmetf qvqvidngfg
       61 mgsddvekvg nryftskchs vqdlenprfy gfrgealani admasaveis skknrtmktf
      121 vklfqsgkal kaceadvtra sagttvtvyn lfyqlpvrrk cmdprlefek vrqriealsl
      181 mhpsisfslr ndvsgsmvlq lpktkdvcsr fcqiyglgks qklreisfky kefelsgyis
      241 seahynknmq flfvnkrlvl rtklhklidf llrkesiick pkngptsrqm nsslrhrstp
      301 elygiyvinv qcqfceydvc mepaktlief qnwdtllfci qegvkmflkq eklfvelsge
      361 dikefsedng fslfdatlqk rvtsdersnf qeacnnilds yemfnlqska vkrkttaenv
      421 ntqssrdsea trkntndafl yiyesggpgh skmtepslqn kdsscseskm leqetivase
      481 agenekhkks flehsslenp cgtslemfls pfqtpchfee sgqdleiwke sttvngmaan
      541 ilknnriqnq pkrfkdatev gcqplpfatt lwgvhsaqte kekkkessnc grrnvfsygr
      601 vklcstgfit hvvqnektks tetehsfkny vrpgptraqe tfgnrtrhsv etpdikdlas
      661 tlskesgqlp nkkncrtnis ygleneptat ytmfsafqeg skksqtdcil sdtspsfpwy
      721 rhvsndsrkt dkligfskpi vrkklslssq lgslekfkrq ygkvenpldt eveesngvtt
      781 nlslqvepdi llkdknrlen sdvckittme hsdsdsscqp ashilnsekf pfskdedcle
      841 qqmpslresp mtlkelslfn rkpldlekss eslasklsrl kgseretqtm gmmsrfnelp
      901 nsdssrkdsk lcsvltqdfc mlfnnkhekt engviptsds atqdnsfnkn skthsnsntt
      961 encvisetpl vlpynnskvt gkdsdvlira seqqigslds psgmlmnpve datgdqngic
     1021 fqseeskara cseteesntc csdwqrhfdv algrmvyvnk mtglstfiap tediqaactk
     1081 dlttvavdvv lengsqyrcq pfrsdlvlpf lpraraertv mrqdnrdtvd dtvsseslqs
     1141 lfsewdnpvf arypevavdv ssgqaeslav kihnilypyr ftkgmihsmq vlqqvdnkfi
     1201 aclmstktee ngeadsyekq qaqgsgrkkl lsstlipple itvteeqrrl lwcyhknled
     1261 lglefvfpdt sdslvlvgkv plcfverean elrrgrstvt ksiveefire qlellqttgg
     1321 iqgtlpltvq kvlasqachg aikfndglsl qescrlieal sscqlpfqca hgrpsmlpla
     1381 didhleqekq ikpnltklrk maqawrlfgk aecdtrqslq qsmppcepp
//
LOCUS       XP_005267589            1418 aa            linear   PRI 05-AUG-2025
DEFINITION  DNA mismatch repair protein Mlh3 isoform X3 [Homo sapiens].
ACCESSION   XP_005267589
VERSION     XP_005267589.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267532.6
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1418
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1418
                     /product="DNA mismatch repair protein Mlh3 isoform X3"
                     /calculated_mol_wt=159708
     Region          9..192
                     /region_name="HATPase_MutL-MLH-PMS-like"
                     /note="Histidine kinase-like ATPase domain of DNA mismatch
                     repair proteins Escherichia coli MutL, human MutL homologs
                     (MLH/ PMS), and related domains; cd16926"
                     /db_xref="CDD:340403"
     Site            order(28,32..33,35..36,54,56,58,60..61,69,74..77,94..97,
                     109,111,143..144,146)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:340403"
     Site            order(70,97)
                     /site_type="other"
                     /note="ATP-lid"
                     /db_xref="CDD:340403"
     Region          206..349
                     /region_name="MutL_Trans_MLH3"
                     /note="transducer domain, having a ribosomal S5 domain
                     2-like fold, found in proteins similar to yeast and human
                     MLH3 (MutL homologue 3). MLH3 belongs to the DNA mismatch
                     repair (MutL/MLH1/PMS2) family. This transducer domain is
                     homologous to the second domain...; cd03486"
                     /db_xref="CDD:239568"
     Site            325
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:239568"
     Region          <1159..1374
                     /region_name="MutL"
                     /note="DNA mismatch repair ATPase MutL [Replication,
                     recombination and repair]; COG0323"
                     /db_xref="CDD:440092"
     CDS             1..1418
                     /gene="MLH3"
                     /gene_synonym="HNPCC7"
                     /coded_by="XM_005267532.6:152..4408"
                     /db_xref="GeneID:27030"
                     /db_xref="HGNC:HGNC:7128"
                     /db_xref="MIM:604395"
ORIGIN      
        1 mikclsvevq aklrsglais slgqcveela lnsidaeakc vavrvnmetf qvqvidngfg
       61 mgsddvekvg nryftskchs vqdlenprfy gfrgealani admasaveis skknrtmktf
      121 vklfqsgkal kaceadvtra sagttvtvyn lfyqlpvrrk cmdprlefek vrqriealsl
      181 mhpsisfslr ndvsgsmvlq lpktkdvcsr fcqiyglgks qklreisfky kefelsgyis
      241 seahynknmq flfvnkrlvl rtklhklidf llrkesiick pkngptsrqm nsslrhrstp
      301 elygiyvinv qcqfceydvc mepaktlief qnwdtllfci qegvkmflkq eklfvelsge
      361 dikefsedng fslfdatlqk rvtsdersnf qeacnnilds yemfnlqska vkrkttaenv
      421 ntqssrdsea trkntndafl yiyesggpgh skmtepslqn kdsscseskm leqetivase
      481 agenekhkks flehsslenp cgtslemfls pfqtpchfee sgqdleiwke sttvngmaan
      541 ilknnriqnq pkrfkdatev gcqplpfatt lwgvhsaqte kekkkessnc grrnvfsygr
      601 vklcstgfit hvvqnektks tetehsfkny vrpgptraqe tfgnrtrhsv etpdikdlas
      661 tlskesgqlp nkkncrtnis ygleneptat ytmfsafqeg skksqtdcil sdtspsfpwy
      721 rhvsndsrkt dkligfskpi vrkklslssq lgslekfkrq ygkvenpldt eveesngvtt
      781 nlslqvepdi llkdknrlen sdvckittme hsdsdsscqp ashilnsekf pfskdedcle
      841 qqmpslresp mtlkelslfn rkpldlekss eslasklsrl kgseretqtm gmmsrfnelp
      901 nsdssrkdsk lcsvltqdfc mlfnnkhekt engviptsds atqdnsfnkn skthsnsntt
      961 encvisetpl vlpynnskvt gkdsdvlira seqqigslds psgmlmnpve datgdqngic
     1021 fqseeskara cseteesntc csdwqrhfdv algrmvyvnk mtglstfiap tediqaactk
     1081 dlttvavdvv lengsqyrcq pfrsdlvlpf lpraraertv mrqdnrdtvd dtvsseslqs
     1141 lfsewdnpvf arypevlqqv dnkfiaclms tkteengeag gnllvlvdqh aaherirleq
     1201 liidsyekqq aqgsgrkkll sstlipplei tvteeqrrll wcyhknledl glefvfpdts
     1261 dslvlvgkvp lcfvereane lrrgrstvtk siveefireq lellqttggi qgtlpltvqk
     1321 vlasqachga ikfndglslq escrlieals scqlpfqcah grpsmlplad idhleqekqi
     1381 kpnltklrkm aqawrlfgka ecdtrqslqq smppcepp
//
LOCUS       XP_024305306            1418 aa            linear   PRI 05-AUG-2025
DEFINITION  DNA mismatch repair protein Mlh3 isoform X3 [Homo sapiens].
ACCESSION   XP_024305306
VERSION     XP_024305306.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449538.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1418
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1418
                     /product="DNA mismatch repair protein Mlh3 isoform X3"
                     /calculated_mol_wt=159708
     Region          9..192
                     /region_name="HATPase_MutL-MLH-PMS-like"
                     /note="Histidine kinase-like ATPase domain of DNA mismatch
                     repair proteins Escherichia coli MutL, human MutL homologs
                     (MLH/ PMS), and related domains; cd16926"
                     /db_xref="CDD:340403"
     Site            order(28,32..33,35..36,54,56,58,60..61,69,74..77,94..97,
                     109,111,143..144,146)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:340403"
     Site            order(70,97)
                     /site_type="other"
                     /note="ATP-lid"
                     /db_xref="CDD:340403"
     Region          206..349
                     /region_name="MutL_Trans_MLH3"
                     /note="transducer domain, having a ribosomal S5 domain
                     2-like fold, found in proteins similar to yeast and human
                     MLH3 (MutL homologue 3). MLH3 belongs to the DNA mismatch
                     repair (MutL/MLH1/PMS2) family. This transducer domain is
                     homologous to the second domain...; cd03486"
                     /db_xref="CDD:239568"
     Site            325
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:239568"
     Region          <1159..1374
                     /region_name="MutL"
                     /note="DNA mismatch repair ATPase MutL [Replication,
                     recombination and repair]; COG0323"
                     /db_xref="CDD:440092"
     CDS             1..1418
                     /gene="MLH3"
                     /gene_synonym="HNPCC7"
                     /coded_by="XM_024449538.2:93..4349"
                     /db_xref="GeneID:27030"
                     /db_xref="HGNC:HGNC:7128"
                     /db_xref="MIM:604395"
ORIGIN      
        1 mikclsvevq aklrsglais slgqcveela lnsidaeakc vavrvnmetf qvqvidngfg
       61 mgsddvekvg nryftskchs vqdlenprfy gfrgealani admasaveis skknrtmktf
      121 vklfqsgkal kaceadvtra sagttvtvyn lfyqlpvrrk cmdprlefek vrqriealsl
      181 mhpsisfslr ndvsgsmvlq lpktkdvcsr fcqiyglgks qklreisfky kefelsgyis
      241 seahynknmq flfvnkrlvl rtklhklidf llrkesiick pkngptsrqm nsslrhrstp
      301 elygiyvinv qcqfceydvc mepaktlief qnwdtllfci qegvkmflkq eklfvelsge
      361 dikefsedng fslfdatlqk rvtsdersnf qeacnnilds yemfnlqska vkrkttaenv
      421 ntqssrdsea trkntndafl yiyesggpgh skmtepslqn kdsscseskm leqetivase
      481 agenekhkks flehsslenp cgtslemfls pfqtpchfee sgqdleiwke sttvngmaan
      541 ilknnriqnq pkrfkdatev gcqplpfatt lwgvhsaqte kekkkessnc grrnvfsygr
      601 vklcstgfit hvvqnektks tetehsfkny vrpgptraqe tfgnrtrhsv etpdikdlas
      661 tlskesgqlp nkkncrtnis ygleneptat ytmfsafqeg skksqtdcil sdtspsfpwy
      721 rhvsndsrkt dkligfskpi vrkklslssq lgslekfkrq ygkvenpldt eveesngvtt
      781 nlslqvepdi llkdknrlen sdvckittme hsdsdsscqp ashilnsekf pfskdedcle
      841 qqmpslresp mtlkelslfn rkpldlekss eslasklsrl kgseretqtm gmmsrfnelp
      901 nsdssrkdsk lcsvltqdfc mlfnnkhekt engviptsds atqdnsfnkn skthsnsntt
      961 encvisetpl vlpynnskvt gkdsdvlira seqqigslds psgmlmnpve datgdqngic
     1021 fqseeskara cseteesntc csdwqrhfdv algrmvyvnk mtglstfiap tediqaactk
     1081 dlttvavdvv lengsqyrcq pfrsdlvlpf lpraraertv mrqdnrdtvd dtvsseslqs
     1141 lfsewdnpvf arypevlqqv dnkfiaclms tkteengeag gnllvlvdqh aaherirleq
     1201 liidsyekqq aqgsgrkkll sstlipplei tvteeqrrll wcyhknledl glefvfpdts
     1261 dslvlvgkvp lcfvereane lrrgrstvtk siveefireq lellqttggi qgtlpltvqk
     1321 vlasqachga ikfndglslq escrlieals scqlpfqcah grpsmlplad idhleqekqi
     1381 kpnltklrkm aqawrlfgka ecdtrqslqq smppcepp
//
LOCUS       XP_005267590            1394 aa            linear   PRI 05-AUG-2025
DEFINITION  DNA mismatch repair protein Mlh3 isoform X4 [Homo sapiens].
ACCESSION   XP_005267590
VERSION     XP_005267590.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267533.6
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1394
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1394
                     /product="DNA mismatch repair protein Mlh3 isoform X4"
                     /calculated_mol_wt=157017
     Region          9..192
                     /region_name="HATPase_MutL-MLH-PMS-like"
                     /note="Histidine kinase-like ATPase domain of DNA mismatch
                     repair proteins Escherichia coli MutL, human MutL homologs
                     (MLH/ PMS), and related domains; cd16926"
                     /db_xref="CDD:340403"
     Site            order(28,32..33,35..36,54,56,58,60..61,69,74..77,94..97,
                     109,111,143..144,146)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:340403"
     Site            order(70,97)
                     /site_type="other"
                     /note="ATP-lid"
                     /db_xref="CDD:340403"
     Region          206..349
                     /region_name="MutL_Trans_MLH3"
                     /note="transducer domain, having a ribosomal S5 domain
                     2-like fold, found in proteins similar to yeast and human
                     MLH3 (MutL homologue 3). MLH3 belongs to the DNA mismatch
                     repair (MutL/MLH1/PMS2) family. This transducer domain is
                     homologous to the second domain...; cd03486"
                     /db_xref="CDD:239568"
     Site            325
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:239568"
     Region          <1182..1350
                     /region_name="MutL"
                     /note="DNA mismatch repair ATPase MutL [Replication,
                     recombination and repair]; COG0323"
                     /db_xref="CDD:440092"
     CDS             1..1394
                     /gene="MLH3"
                     /gene_synonym="HNPCC7"
                     /coded_by="XM_005267533.6:152..4336"
                     /db_xref="GeneID:27030"
                     /db_xref="HGNC:HGNC:7128"
                     /db_xref="MIM:604395"
ORIGIN      
        1 mikclsvevq aklrsglais slgqcveela lnsidaeakc vavrvnmetf qvqvidngfg
       61 mgsddvekvg nryftskchs vqdlenprfy gfrgealani admasaveis skknrtmktf
      121 vklfqsgkal kaceadvtra sagttvtvyn lfyqlpvrrk cmdprlefek vrqriealsl
      181 mhpsisfslr ndvsgsmvlq lpktkdvcsr fcqiyglgks qklreisfky kefelsgyis
      241 seahynknmq flfvnkrlvl rtklhklidf llrkesiick pkngptsrqm nsslrhrstp
      301 elygiyvinv qcqfceydvc mepaktlief qnwdtllfci qegvkmflkq eklfvelsge
      361 dikefsedng fslfdatlqk rvtsdersnf qeacnnilds yemfnlqska vkrkttaenv
      421 ntqssrdsea trkntndafl yiyesggpgh skmtepslqn kdsscseskm leqetivase
      481 agenekhkks flehsslenp cgtslemfls pfqtpchfee sgqdleiwke sttvngmaan
      541 ilknnriqnq pkrfkdatev gcqplpfatt lwgvhsaqte kekkkessnc grrnvfsygr
      601 vklcstgfit hvvqnektks tetehsfkny vrpgptraqe tfgnrtrhsv etpdikdlas
      661 tlskesgqlp nkkncrtnis ygleneptat ytmfsafqeg skksqtdcil sdtspsfpwy
      721 rhvsndsrkt dkligfskpi vrkklslssq lgslekfkrq ygkvenpldt eveesngvtt
      781 nlslqvepdi llkdknrlen sdvckittme hsdsdsscqp ashilnsekf pfskdedcle
      841 qqmpslresp mtlkelslfn rkpldlekss eslasklsrl kgseretqtm gmmsrfnelp
      901 nsdssrkdsk lcsvltqdfc mlfnnkhekt engviptsds atqdnsfnkn skthsnsntt
      961 encvisetpl vlpynnskvt gkdsdvlira seqqigslds psgmlmnpve datgdqngic
     1021 fqseeskara cseteesntc csdwqrhfdv algrmvyvnk mtglstfiap tediqaactk
     1081 dlttvavdvv lengsqyrcq pfrsdlvlpf lpraraertv mrqdnrdtvd dtvsseslqs
     1141 lfsewdnpvf arypevlqqv dnkfiaclms tkteengead syekqqaqgs grkkllsstl
     1201 ippleitvte eqrrllwcyh knledlglef vfpdtsdslv lvgkvplcfv ereanelrrg
     1261 rstvtksive efireqlell qttggiqgtl pltvqkvlas qachgaikfn dglslqescr
     1321 liealsscql pfqcahgrps mlpladidhl eqekqikpnl tklrkmaqaw rlfgkaecdt
     1381 rqslqqsmpp cepp
//
LOCUS       XP_047287221            1394 aa            linear   PRI 05-AUG-2025
DEFINITION  DNA mismatch repair protein Mlh3 isoform X4 [Homo sapiens].
ACCESSION   XP_047287221
VERSION     XP_047287221.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431265.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1394
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1394
                     /product="DNA mismatch repair protein Mlh3 isoform X4"
                     /calculated_mol_wt=157017
     Region          9..192
                     /region_name="HATPase_MutL-MLH-PMS-like"
                     /note="Histidine kinase-like ATPase domain of DNA mismatch
                     repair proteins Escherichia coli MutL, human MutL homologs
                     (MLH/ PMS), and related domains; cd16926"
                     /db_xref="CDD:340403"
     Site            order(28,32..33,35..36,54,56,58,60..61,69,74..77,94..97,
                     109,111,143..144,146)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:340403"
     Site            order(70,97)
                     /site_type="other"
                     /note="ATP-lid"
                     /db_xref="CDD:340403"
     Region          206..349
                     /region_name="MutL_Trans_MLH3"
                     /note="transducer domain, having a ribosomal S5 domain
                     2-like fold, found in proteins similar to yeast and human
                     MLH3 (MutL homologue 3). MLH3 belongs to the DNA mismatch
                     repair (MutL/MLH1/PMS2) family. This transducer domain is
                     homologous to the second domain...; cd03486"
                     /db_xref="CDD:239568"
     Site            325
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:239568"
     Region          <1182..1350
                     /region_name="MutL"
                     /note="DNA mismatch repair ATPase MutL [Replication,
                     recombination and repair]; COG0323"
                     /db_xref="CDD:440092"
     CDS             1..1394
                     /gene="MLH3"
                     /gene_synonym="HNPCC7"
                     /coded_by="XM_047431265.1:93..4277"
                     /db_xref="GeneID:27030"
                     /db_xref="HGNC:HGNC:7128"
                     /db_xref="MIM:604395"
ORIGIN      
        1 mikclsvevq aklrsglais slgqcveela lnsidaeakc vavrvnmetf qvqvidngfg
       61 mgsddvekvg nryftskchs vqdlenprfy gfrgealani admasaveis skknrtmktf
      121 vklfqsgkal kaceadvtra sagttvtvyn lfyqlpvrrk cmdprlefek vrqriealsl
      181 mhpsisfslr ndvsgsmvlq lpktkdvcsr fcqiyglgks qklreisfky kefelsgyis
      241 seahynknmq flfvnkrlvl rtklhklidf llrkesiick pkngptsrqm nsslrhrstp
      301 elygiyvinv qcqfceydvc mepaktlief qnwdtllfci qegvkmflkq eklfvelsge
      361 dikefsedng fslfdatlqk rvtsdersnf qeacnnilds yemfnlqska vkrkttaenv
      421 ntqssrdsea trkntndafl yiyesggpgh skmtepslqn kdsscseskm leqetivase
      481 agenekhkks flehsslenp cgtslemfls pfqtpchfee sgqdleiwke sttvngmaan
      541 ilknnriqnq pkrfkdatev gcqplpfatt lwgvhsaqte kekkkessnc grrnvfsygr
      601 vklcstgfit hvvqnektks tetehsfkny vrpgptraqe tfgnrtrhsv etpdikdlas
      661 tlskesgqlp nkkncrtnis ygleneptat ytmfsafqeg skksqtdcil sdtspsfpwy
      721 rhvsndsrkt dkligfskpi vrkklslssq lgslekfkrq ygkvenpldt eveesngvtt
      781 nlslqvepdi llkdknrlen sdvckittme hsdsdsscqp ashilnsekf pfskdedcle
      841 qqmpslresp mtlkelslfn rkpldlekss eslasklsrl kgseretqtm gmmsrfnelp
      901 nsdssrkdsk lcsvltqdfc mlfnnkhekt engviptsds atqdnsfnkn skthsnsntt
      961 encvisetpl vlpynnskvt gkdsdvlira seqqigslds psgmlmnpve datgdqngic
     1021 fqseeskara cseteesntc csdwqrhfdv algrmvyvnk mtglstfiap tediqaactk
     1081 dlttvavdvv lengsqyrcq pfrsdlvlpf lpraraertv mrqdnrdtvd dtvsseslqs
     1141 lfsewdnpvf arypevlqqv dnkfiaclms tkteengead syekqqaqgs grkkllsstl
     1201 ippleitvte eqrrllwcyh knledlglef vfpdtsdslv lvgkvplcfv ereanelrrg
     1261 rstvtksive efireqlell qttggiqgtl pltvqkvlas qachgaikfn dglslqescr
     1321 liealsscql pfqcahgrps mlpladidhl eqekqikpnl tklrkmaqaw rlfgkaecdt
     1381 rqslqqsmpp cepp
//
LOCUS       XP_047287222            1297 aa            linear   PRI 05-AUG-2025
DEFINITION  DNA mismatch repair protein Mlh3 isoform X5 [Homo sapiens].
ACCESSION   XP_047287222
VERSION     XP_047287222.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431266.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1297
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1297
                     /product="DNA mismatch repair protein Mlh3 isoform X5"
                     /calculated_mol_wt=146176
     Region          9..192
                     /region_name="HATPase_MutL-MLH-PMS-like"
                     /note="Histidine kinase-like ATPase domain of DNA mismatch
                     repair proteins Escherichia coli MutL, human MutL homologs
                     (MLH/ PMS), and related domains; cd16926"
                     /db_xref="CDD:340403"
     Site            order(28,32..33,35..36,54,56,58,60..61,69,74..77,94..97,
                     109,111,143..144,146)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:340403"
     Site            order(70,97)
                     /site_type="other"
                     /note="ATP-lid"
                     /db_xref="CDD:340403"
     Region          206..349
                     /region_name="MutL_Trans_MLH3"
                     /note="transducer domain, having a ribosomal S5 domain
                     2-like fold, found in proteins similar to yeast and human
                     MLH3 (MutL homologue 3). MLH3 belongs to the DNA mismatch
                     repair (MutL/MLH1/PMS2) family. This transducer domain is
                     homologous to the second domain...; cd03486"
                     /db_xref="CDD:239568"
     Site            325
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:239568"
     Region          1191..>1280
                     /region_name="MutL_C"
                     /note="MutL C terminal dimerisation domain; smart00853"
                     /db_xref="CDD:214857"
     CDS             1..1297
                     /gene="MLH3"
                     /gene_synonym="HNPCC7"
                     /coded_by="XM_047431266.1:152..4045"
                     /db_xref="GeneID:27030"
                     /db_xref="HGNC:HGNC:7128"
                     /db_xref="MIM:604395"
ORIGIN      
        1 mikclsvevq aklrsglais slgqcveela lnsidaeakc vavrvnmetf qvqvidngfg
       61 mgsddvekvg nryftskchs vqdlenprfy gfrgealani admasaveis skknrtmktf
      121 vklfqsgkal kaceadvtra sagttvtvyn lfyqlpvrrk cmdprlefek vrqriealsl
      181 mhpsisfslr ndvsgsmvlq lpktkdvcsr fcqiyglgks qklreisfky kefelsgyis
      241 seahynknmq flfvnkrlvl rtklhklidf llrkesiick pkngptsrqm nsslrhrstp
      301 elygiyvinv qcqfceydvc mepaktlief qnwdtllfci qegvkmflkq eklfvelsge
      361 dikefsedng fslfdatlqk rvtsdersnf qeacnnilds yemfnlqska vkrkttaenv
      421 ntqssrdsea trkntndafl yiyesggpgh skmtepslqn kdsscseskm leqetivase
      481 agenekhkks flehsslenp cgtslemfls pfqtpchfee sgqdleiwke sttvngmaan
      541 ilknnriqnq pkrfkdatev gcqplpfatt lwgvhsaqte kekkkessnc grrnvfsygr
      601 vklcstgfit hvvqnektks tetehsfkny vrpgptraqe tfgnrtrhsv etpdikdlas
      661 tlskesgqlp nkkncrtnis ygleneptat ytmfsafqeg skksqtdcil sdtspsfpwy
      721 rhvsndsrkt dkligfskpi vrkklslssq lgslekfkrq ygkvenpldt eveesngvtt
      781 nlslqvepdi llkdknrlen sdvckittme hsdsdsscqp ashilnsekf pfskdedcle
      841 qqmpslresp mtlkelslfn rkpldlekss eslasklsrl kgseretqtm gmmsrfnelp
      901 nsdssrkdsk lcsvltqdfc mlfnnkhekt engviptsds atqdnsfnkn skthsnsntt
      961 encvisetpl vlpynnskvt gkdsdvlira seqqigslds psgmlmnpve datgdqngic
     1021 fqseeskara cseteesntc csdwqrhfdv algrmvyvnk mtglstfiap tediqaactk
     1081 dlttvavdvv lengsqyrcq pfrsdlvlpf lpraraertv mrqdnrdtvd dtvsseslqs
     1141 lfsewdnpvf arypevavdv ssgqaeslav kihnilypyr ftkgmihsmq vlqqvdnkfi
     1201 aclmstktee ngeaggnllv lvdqhaaher irleqliids yekqqaqgsg rkkllsstli
     1261 ppleitvtee qrrllwnlse nnwsysrppe askghch
//
LOCUS       XP_047287223            1279 aa            linear   PRI 05-AUG-2025
DEFINITION  DNA mismatch repair protein Mlh3 isoform X6 [Homo sapiens].
ACCESSION   XP_047287223
VERSION     XP_047287223.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431267.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1279
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1279
                     /product="DNA mismatch repair protein Mlh3 isoform X6"
                     /calculated_mol_wt=144093
     Region          9..192
                     /region_name="HATPase_MutL-MLH-PMS-like"
                     /note="Histidine kinase-like ATPase domain of DNA mismatch
                     repair proteins Escherichia coli MutL, human MutL homologs
                     (MLH/ PMS), and related domains; cd16926"
                     /db_xref="CDD:340403"
     Site            order(28,32..33,35..36,54,56,58,60..61,69,74..77,94..97,
                     109,111,143..144,146)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:340403"
     Site            order(70,97)
                     /site_type="other"
                     /note="ATP-lid"
                     /db_xref="CDD:340403"
     Region          206..349
                     /region_name="MutL_Trans_MLH3"
                     /note="transducer domain, having a ribosomal S5 domain
                     2-like fold, found in proteins similar to yeast and human
                     MLH3 (MutL homologue 3). MLH3 belongs to the DNA mismatch
                     repair (MutL/MLH1/PMS2) family. This transducer domain is
                     homologous to the second domain...; cd03486"
                     /db_xref="CDD:239568"
     Site            325
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:239568"
     Region          1191..>1275
                     /region_name="MutL_C"
                     /note="MutL C terminal dimerisation domain; smart00853"
                     /db_xref="CDD:214857"
     CDS             1..1279
                     /gene="MLH3"
                     /gene_synonym="HNPCC7"
                     /coded_by="XM_047431267.1:152..3991"
                     /db_xref="GeneID:27030"
                     /db_xref="HGNC:HGNC:7128"
                     /db_xref="MIM:604395"
ORIGIN      
        1 mikclsvevq aklrsglais slgqcveela lnsidaeakc vavrvnmetf qvqvidngfg
       61 mgsddvekvg nryftskchs vqdlenprfy gfrgealani admasaveis skknrtmktf
      121 vklfqsgkal kaceadvtra sagttvtvyn lfyqlpvrrk cmdprlefek vrqriealsl
      181 mhpsisfslr ndvsgsmvlq lpktkdvcsr fcqiyglgks qklreisfky kefelsgyis
      241 seahynknmq flfvnkrlvl rtklhklidf llrkesiick pkngptsrqm nsslrhrstp
      301 elygiyvinv qcqfceydvc mepaktlief qnwdtllfci qegvkmflkq eklfvelsge
      361 dikefsedng fslfdatlqk rvtsdersnf qeacnnilds yemfnlqska vkrkttaenv
      421 ntqssrdsea trkntndafl yiyesggpgh skmtepslqn kdsscseskm leqetivase
      481 agenekhkks flehsslenp cgtslemfls pfqtpchfee sgqdleiwke sttvngmaan
      541 ilknnriqnq pkrfkdatev gcqplpfatt lwgvhsaqte kekkkessnc grrnvfsygr
      601 vklcstgfit hvvqnektks tetehsfkny vrpgptraqe tfgnrtrhsv etpdikdlas
      661 tlskesgqlp nkkncrtnis ygleneptat ytmfsafqeg skksqtdcil sdtspsfpwy
      721 rhvsndsrkt dkligfskpi vrkklslssq lgslekfkrq ygkvenpldt eveesngvtt
      781 nlslqvepdi llkdknrlen sdvckittme hsdsdsscqp ashilnsekf pfskdedcle
      841 qqmpslresp mtlkelslfn rkpldlekss eslasklsrl kgseretqtm gmmsrfnelp
      901 nsdssrkdsk lcsvltqdfc mlfnnkhekt engviptsds atqdnsfnkn skthsnsntt
      961 encvisetpl vlpynnskvt gkdsdvlira seqqigslds psgmlmnpve datgdqngic
     1021 fqseeskara cseteesntc csdwqrhfdv algrmvyvnk mtglstfiap tediqaactk
     1081 dlttvavdvv lengsqyrcq pfrsdlvlpf lpraraertv mrqdnrdtvd dtvsseslqs
     1141 lfsewdnpvf arypevavdv ssgqaeslav kihnilypyr ftkgmihsmq vlqqvdnkfi
     1201 aclmstktee ngeaggnllv lvdqhaaher irleqliids yekqqaqgsg rkkllsstli
     1261 ppleitvtee qrrllwlsl
//
LOCUS       XP_005267591            1275 aa            linear   PRI 05-AUG-2025
DEFINITION  DNA mismatch repair protein Mlh3 isoform X7 [Homo sapiens].
ACCESSION   XP_005267591
VERSION     XP_005267591.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267534.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1275
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1275
                     /product="DNA mismatch repair protein Mlh3 isoform X7"
                     /calculated_mol_wt=143594
     Region          9..192
                     /region_name="HATPase_MutL-MLH-PMS-like"
                     /note="Histidine kinase-like ATPase domain of DNA mismatch
                     repair proteins Escherichia coli MutL, human MutL homologs
                     (MLH/ PMS), and related domains; cd16926"
                     /db_xref="CDD:340403"
     Site            order(28,32..33,35..36,54,56,58,60..61,69,74..77,94..97,
                     109,111,143..144,146)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:340403"
     Site            order(70,97)
                     /site_type="other"
                     /note="ATP-lid"
                     /db_xref="CDD:340403"
     Region          206..349
                     /region_name="MutL_Trans_MLH3"
                     /note="transducer domain, having a ribosomal S5 domain
                     2-like fold, found in proteins similar to yeast and human
                     MLH3 (MutL homologue 3). MLH3 belongs to the DNA mismatch
                     repair (MutL/MLH1/PMS2) family. This transducer domain is
                     homologous to the second domain...; cd03486"
                     /db_xref="CDD:239568"
     Site            325
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:239568"
     Region          1191..>1275
                     /region_name="MutL_C"
                     /note="MutL C terminal dimerisation domain; smart00853"
                     /db_xref="CDD:214857"
     CDS             1..1275
                     /gene="MLH3"
                     /gene_synonym="HNPCC7"
                     /coded_by="XM_005267534.4:152..3979"
                     /db_xref="GeneID:27030"
                     /db_xref="HGNC:HGNC:7128"
                     /db_xref="MIM:604395"
ORIGIN      
        1 mikclsvevq aklrsglais slgqcveela lnsidaeakc vavrvnmetf qvqvidngfg
       61 mgsddvekvg nryftskchs vqdlenprfy gfrgealani admasaveis skknrtmktf
      121 vklfqsgkal kaceadvtra sagttvtvyn lfyqlpvrrk cmdprlefek vrqriealsl
      181 mhpsisfslr ndvsgsmvlq lpktkdvcsr fcqiyglgks qklreisfky kefelsgyis
      241 seahynknmq flfvnkrlvl rtklhklidf llrkesiick pkngptsrqm nsslrhrstp
      301 elygiyvinv qcqfceydvc mepaktlief qnwdtllfci qegvkmflkq eklfvelsge
      361 dikefsedng fslfdatlqk rvtsdersnf qeacnnilds yemfnlqska vkrkttaenv
      421 ntqssrdsea trkntndafl yiyesggpgh skmtepslqn kdsscseskm leqetivase
      481 agenekhkks flehsslenp cgtslemfls pfqtpchfee sgqdleiwke sttvngmaan
      541 ilknnriqnq pkrfkdatev gcqplpfatt lwgvhsaqte kekkkessnc grrnvfsygr
      601 vklcstgfit hvvqnektks tetehsfkny vrpgptraqe tfgnrtrhsv etpdikdlas
      661 tlskesgqlp nkkncrtnis ygleneptat ytmfsafqeg skksqtdcil sdtspsfpwy
      721 rhvsndsrkt dkligfskpi vrkklslssq lgslekfkrq ygkvenpldt eveesngvtt
      781 nlslqvepdi llkdknrlen sdvckittme hsdsdsscqp ashilnsekf pfskdedcle
      841 qqmpslresp mtlkelslfn rkpldlekss eslasklsrl kgseretqtm gmmsrfnelp
      901 nsdssrkdsk lcsvltqdfc mlfnnkhekt engviptsds atqdnsfnkn skthsnsntt
      961 encvisetpl vlpynnskvt gkdsdvlira seqqigslds psgmlmnpve datgdqngic
     1021 fqseeskara cseteesntc csdwqrhfdv algrmvyvnk mtglstfiap tediqaactk
     1081 dlttvavdvv lengsqyrcq pfrsdlvlpf lpraraertv mrqdnrdtvd dtvsseslqs
     1141 lfsewdnpvf arypevavdv ssgqaeslav kihnilypyr ftkgmihsmq vlqqvdnkfi
     1201 aclmstktee ngeaggnllv lvdqhaaher irleqliids yekqqaqgsg rkkllsstli
     1261 ppleitvtee qrrll
//
LOCUS       XP_047287224            1220 aa            linear   PRI 05-AUG-2025
DEFINITION  DNA mismatch repair protein Mlh3 isoform X8 [Homo sapiens].
ACCESSION   XP_047287224
VERSION     XP_047287224.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431268.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1220
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1220
                     /product="DNA mismatch repair protein Mlh3 isoform X8"
                     /calculated_mol_wt=137530
     Region          9..192
                     /region_name="HATPase_MutL-MLH-PMS-like"
                     /note="Histidine kinase-like ATPase domain of DNA mismatch
                     repair proteins Escherichia coli MutL, human MutL homologs
                     (MLH/ PMS), and related domains; cd16926"
                     /db_xref="CDD:340403"
     Site            order(28,32..33,35..36,54,56,58,60..61,69,74..77,94..97,
                     109,111,143..144,146)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:340403"
     Site            order(70,97)
                     /site_type="other"
                     /note="ATP-lid"
                     /db_xref="CDD:340403"
     Region          206..349
                     /region_name="MutL_Trans_MLH3"
                     /note="transducer domain, having a ribosomal S5 domain
                     2-like fold, found in proteins similar to yeast and human
                     MLH3 (MutL homologue 3). MLH3 belongs to the DNA mismatch
                     repair (MutL/MLH1/PMS2) family. This transducer domain is
                     homologous to the second domain...; cd03486"
                     /db_xref="CDD:239568"
     Site            325
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:239568"
     CDS             1..1220
                     /gene="MLH3"
                     /gene_synonym="HNPCC7"
                     /coded_by="XM_047431268.1:152..3814"
                     /db_xref="GeneID:27030"
                     /db_xref="HGNC:HGNC:7128"
                     /db_xref="MIM:604395"
ORIGIN      
        1 mikclsvevq aklrsglais slgqcveela lnsidaeakc vavrvnmetf qvqvidngfg
       61 mgsddvekvg nryftskchs vqdlenprfy gfrgealani admasaveis skknrtmktf
      121 vklfqsgkal kaceadvtra sagttvtvyn lfyqlpvrrk cmdprlefek vrqriealsl
      181 mhpsisfslr ndvsgsmvlq lpktkdvcsr fcqiyglgks qklreisfky kefelsgyis
      241 seahynknmq flfvnkrlvl rtklhklidf llrkesiick pkngptsrqm nsslrhrstp
      301 elygiyvinv qcqfceydvc mepaktlief qnwdtllfci qegvkmflkq eklfvelsge
      361 dikefsedng fslfdatlqk rvtsdersnf qeacnnilds yemfnlqska vkrkttaenv
      421 ntqssrdsea trkntndafl yiyesggpgh skmtepslqn kdsscseskm leqetivase
      481 agenekhkks flehsslenp cgtslemfls pfqtpchfee sgqdleiwke sttvngmaan
      541 ilknnriqnq pkrfkdatev gcqplpfatt lwgvhsaqte kekkkessnc grrnvfsygr
      601 vklcstgfit hvvqnektks tetehsfkny vrpgptraqe tfgnrtrhsv etpdikdlas
      661 tlskesgqlp nkkncrtnis ygleneptat ytmfsafqeg skksqtdcil sdtspsfpwy
      721 rhvsndsrkt dkligfskpi vrkklslssq lgslekfkrq ygkvenpldt eveesngvtt
      781 nlslqvepdi llkdknrlen sdvckittme hsdsdsscqp ashilnsekf pfskdedcle
      841 qqmpslresp mtlkelslfn rkpldlekss eslasklsrl kgseretqtm gmmsrfnelp
      901 nsdssrkdsk lcsvltqdfc mlfnnkhekt engviptsds atqdnsfnkn skthsnsntt
      961 encvisetpl vlpynnskvt gkdsdvlira seqqigslds psgmlmnpve datgdqngic
     1021 fqseeskara cseteesntc csdwqrhfdv algrmvyvnk mtglstfiap tediqaactk
     1081 dlttvavdvv lengsqyrcq pfrsdlvlpf lpraraertv mrqdnrdtvd dtvsseslqs
     1141 lfsewdnpvf arypevlqqv dnkfiaclms tkteengead syekqqaqgs grkkllsstl
     1201 ippleitvte eqrrllwlsl
//
LOCUS       XP_047287225            1157 aa            linear   PRI 05-AUG-2025
DEFINITION  DNA mismatch repair protein Mlh3 isoform X9 [Homo sapiens].
ACCESSION   XP_047287225
VERSION     XP_047287225.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431269.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1157
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1157
                     /product="DNA mismatch repair protein Mlh3 isoform X9"
                     /calculated_mol_wt=130418
     Region          9..192
                     /region_name="HATPase_MutL-MLH-PMS-like"
                     /note="Histidine kinase-like ATPase domain of DNA mismatch
                     repair proteins Escherichia coli MutL, human MutL homologs
                     (MLH/ PMS), and related domains; cd16926"
                     /db_xref="CDD:340403"
     Site            order(28,32..33,35..36,54,56,58,60..61,69,74..77,94..97,
                     109,111,143..144,146)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:340403"
     Site            order(70,97)
                     /site_type="other"
                     /note="ATP-lid"
                     /db_xref="CDD:340403"
     Region          206..349
                     /region_name="MutL_Trans_MLH3"
                     /note="transducer domain, having a ribosomal S5 domain
                     2-like fold, found in proteins similar to yeast and human
                     MLH3 (MutL homologue 3). MLH3 belongs to the DNA mismatch
                     repair (MutL/MLH1/PMS2) family. This transducer domain is
                     homologous to the second domain...; cd03486"
                     /db_xref="CDD:239568"
     Site            325
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:239568"
     CDS             1..1157
                     /gene="MLH3"
                     /gene_synonym="HNPCC7"
                     /coded_by="XM_047431269.1:152..3625"
                     /db_xref="GeneID:27030"
                     /db_xref="HGNC:HGNC:7128"
                     /db_xref="MIM:604395"
ORIGIN      
        1 mikclsvevq aklrsglais slgqcveela lnsidaeakc vavrvnmetf qvqvidngfg
       61 mgsddvekvg nryftskchs vqdlenprfy gfrgealani admasaveis skknrtmktf
      121 vklfqsgkal kaceadvtra sagttvtvyn lfyqlpvrrk cmdprlefek vrqriealsl
      181 mhpsisfslr ndvsgsmvlq lpktkdvcsr fcqiyglgks qklreisfky kefelsgyis
      241 seahynknmq flfvnkrlvl rtklhklidf llrkesiick pkngptsrqm nsslrhrstp
      301 elygiyvinv qcqfceydvc mepaktlief qnwdtllfci qegvkmflkq eklfvelsge
      361 dikefsedng fslfdatlqk rvtsdersnf qeacnnilds yemfnlqska vkrkttaenv
      421 ntqssrdsea trkntndafl yiyesggpgh skmtepslqn kdsscseskm leqetivase
      481 agenekhkks flehsslenp cgtslemfls pfqtpchfee sgqdleiwke sttvngmaan
      541 ilknnriqnq pkrfkdatev gcqplpfatt lwgvhsaqte kekkkessnc grrnvfsygr
      601 vklcstgfit hvvqnektks tetehsfkny vrpgptraqe tfgnrtrhsv etpdikdlas
      661 tlskesgqlp nkkncrtnis ygleneptat ytmfsafqeg skksqtdcil sdtspsfpwy
      721 rhvsndsrkt dkligfskpi vrkklslssq lgslekfkrq ygkvenpldt eveesngvtt
      781 nlslqvepdi llkdknrlen sdvckittme hsdsdsscqp ashilnsekf pfskdedcle
      841 qqmpslresp mtlkelslfn rkpldlekss eslasklsrl kgseretqtm gmmsrfnelp
      901 nsdssrkdsk lcsvltqdfc mlfnnkhekt engviptsds atqdnsfnkn skthsnsntt
      961 encvisetpl vlpynnskvt gkdsdvlira seqqigslds psgmlmnpve datgdqngic
     1021 fqseeskara cseteesntc csdwqrhfdv algrmvyvnk mtglstfiap tediqaactk
     1081 dlttvavdvv lengsqyrcq pfrsdlvlpf lpraraertv mrqdnrdtvd dtvsseslqs
     1141 lfsewdnpvf arypesf
//
LOCUS       XP_011534954             244 aa            linear   PRI 05-AUG-2025
DEFINITION  ATP synthase subunit s, mitochondrial isoform X1 [Homo sapiens].
ACCESSION   XP_011534954
VERSION     XP_011534954.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536652.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XP_011534954.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..244
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..244
                     /product="ATP synthase subunit s, mitochondrial isoform
                     X1"
                     /calculated_mol_wt=27983
     Region          155..179
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          180..208
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     CDS             1..244
                     /gene="DMAC2L"
                     /gene_synonym="ATP5S; ATPW; FB; HSU79253"
                     /coded_by="XM_011536652.2:1941..2675"
                     /db_xref="GeneID:27109"
                     /db_xref="HGNC:HGNC:18799"
                     /db_xref="MIM:618579"
ORIGIN      
        1 mvlktggfpa qvlslhaaih vrcdllllaf hhdceaspam wnyqmmpfgk isqqlcgvkk
       61 lpwscdsryf wgwlnavfnk vdydrirdvg pdraasewll rcgamvryhg qerwqkdynh
      121 lptgpldkyk iqaidatdsc imsigfdhme glehvekirl ckchyieddc llrlsqlenl
      181 qktilemeii scgnitdkgi ialrhlrnlk ylllsdlpgv rekenlvqaf ktalpslelk
      241 lqlk
//
LOCUS       XP_047287226             200 aa            linear   PRI 05-AUG-2025
DEFINITION  ATP synthase subunit s, mitochondrial isoform X2 [Homo sapiens].
ACCESSION   XP_047287226
VERSION     XP_047287226.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431270.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..200
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..200
                     /product="ATP synthase subunit s, mitochondrial isoform
                     X2"
                     /calculated_mol_wt=23095
     Region          111..135
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          136..164
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     CDS             1..200
                     /gene="DMAC2L"
                     /gene_synonym="ATP5S; ATPW; FB; HSU79253"
                     /coded_by="XM_047431270.1:72..674"
                     /db_xref="GeneID:27109"
                     /db_xref="HGNC:HGNC:18799"
                     /db_xref="MIM:618579"
ORIGIN      
        1 mmpfgkisqq lcgvkklpws cdsryfwgwl navfnkvdyd rirdvgpdra asewllrcga
       61 mvryhgqerw qkdynhlptg pldkykiqai datdscimsi gfdhmegleh vekirlckch
      121 yieddcllrl sqlenlqkti lemeiiscgn itdkgiialr hlrnlkylll sdlpgvreke
      181 nlvqafktal pslelklqlk
//
LOCUS       XP_005267594             200 aa            linear   PRI 05-AUG-2025
DEFINITION  ATP synthase subunit s, mitochondrial isoform X2 [Homo sapiens].
ACCESSION   XP_005267594
VERSION     XP_005267594.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267537.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..200
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..200
                     /product="ATP synthase subunit s, mitochondrial isoform
                     X2"
                     /calculated_mol_wt=23095
     Region          111..135
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          136..164
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     CDS             1..200
                     /gene="DMAC2L"
                     /gene_synonym="ATP5S; ATPW; FB; HSU79253"
                     /coded_by="XM_005267537.5:820..1422"
                     /db_xref="GeneID:27109"
                     /db_xref="HGNC:HGNC:18799"
                     /db_xref="MIM:618579"
ORIGIN      
        1 mmpfgkisqq lcgvkklpws cdsryfwgwl navfnkvdyd rirdvgpdra asewllrcga
       61 mvryhgqerw qkdynhlptg pldkykiqai datdscimsi gfdhmegleh vekirlckch
      121 yieddcllrl sqlenlqkti lemeiiscgn itdkgiialr hlrnlkylll sdlpgvreke
      181 nlvqafktal pslelklqlk
//
LOCUS       XP_047287227             200 aa            linear   PRI 05-AUG-2025
DEFINITION  ATP synthase subunit s, mitochondrial isoform X2 [Homo sapiens].
ACCESSION   XP_047287227
VERSION     XP_047287227.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431271.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..200
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..200
                     /product="ATP synthase subunit s, mitochondrial isoform
                     X2"
                     /calculated_mol_wt=23095
     Region          111..135
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          136..164
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     CDS             1..200
                     /gene="DMAC2L"
                     /gene_synonym="ATP5S; ATPW; FB; HSU79253"
                     /coded_by="XM_047431271.1:845..1447"
                     /db_xref="GeneID:27109"
                     /db_xref="HGNC:HGNC:18799"
                     /db_xref="MIM:618579"
ORIGIN      
        1 mmpfgkisqq lcgvkklpws cdsryfwgwl navfnkvdyd rirdvgpdra asewllrcga
       61 mvryhgqerw qkdynhlptg pldkykiqai datdscimsi gfdhmegleh vekirlckch
      121 yieddcllrl sqlenlqkti lemeiiscgn itdkgiialr hlrnlkylll sdlpgvreke
      181 nlvqafktal pslelklqlk
//
LOCUS       XP_047287228             164 aa            linear   PRI 05-AUG-2025
DEFINITION  ATP synthase subunit s, mitochondrial isoform X3 [Homo sapiens].
ACCESSION   XP_047287228
VERSION     XP_047287228.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431272.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..164
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..164
                     /product="ATP synthase subunit s, mitochondrial isoform
                     X3"
                     /calculated_mol_wt=18960
     CDS             1..164
                     /gene="DMAC2L"
                     /gene_synonym="ATP5S; ATPW; FB; HSU79253"
                     /coded_by="XM_047431272.1:72..566"
                     /db_xref="GeneID:27109"
                     /db_xref="HGNC:HGNC:18799"
                     /db_xref="MIM:618579"
ORIGIN      
        1 mmpfgkisqq lcgvkklpws cdsryfwgwl navfnkvdyd rirdvgpdra asewllrcga
       61 mvryhgqerw qkdynhlptg pldkykiqai datdscimsi gfdhmegleh vekirlckch
      121 yieddcllrl sqlenlqkti lemeiiscgn itdkgiialr hlra
//
LOCUS       XP_047287229             121 aa            linear   PRI 05-AUG-2025
DEFINITION  ATP synthase subunit s, mitochondrial isoform X4 [Homo sapiens].
ACCESSION   XP_047287229
VERSION     XP_047287229.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431273.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..121
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..121
                     /product="ATP synthase subunit s, mitochondrial isoform
                     X4"
                     /calculated_mol_wt=13914
     CDS             1..121
                     /gene="DMAC2L"
                     /gene_synonym="ATP5S; ATPW; FB; HSU79253"
                     /coded_by="XM_047431273.1:72..437"
                     /db_xref="GeneID:27109"
                     /db_xref="HGNC:HGNC:18799"
                     /db_xref="MIM:618579"
ORIGIN      
        1 mmpfgkisqq lcgvkklpws cdsryfwgwl navfnkvdyd rirdvgpdra asewllrcga
       61 mvryhgqerw qkdynhlptg pldkykiqai datdscimsi gfdhmgnypi vllienaddl
      121 q
//
LOCUS       XP_047287230             112 aa            linear   PRI 05-AUG-2025
DEFINITION  ATP synthase subunit s, mitochondrial isoform X5 [Homo sapiens].
ACCESSION   XP_047287230
VERSION     XP_047287230.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431274.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..112
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..112
                     /product="ATP synthase subunit s, mitochondrial isoform
                     X5"
                     /calculated_mol_wt=12896
     CDS             1..112
                     /gene="DMAC2L"
                     /gene_synonym="ATP5S; ATPW; FB; HSU79253"
                     /coded_by="XM_047431274.1:72..410"
                     /db_xref="GeneID:27109"
                     /db_xref="HGNC:HGNC:18799"
                     /db_xref="MIM:618579"
ORIGIN      
        1 mmpfgkisqq lcgvkklpws cdsryfwgwl navfnkvdyd rirdvgpdra asewllrcga
       61 mvryhgqerw qkdynhlptg pldkykiqai datdscimsi gfdhmetsni cc
//
LOCUS       XP_011534959             112 aa            linear   PRI 05-AUG-2025
DEFINITION  ATP synthase subunit s, mitochondrial isoform X5 [Homo sapiens].
ACCESSION   XP_011534959
VERSION     XP_011534959.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536657.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..112
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..112
                     /product="ATP synthase subunit s, mitochondrial isoform
                     X5"
                     /calculated_mol_wt=12896
     CDS             1..112
                     /gene="DMAC2L"
                     /gene_synonym="ATP5S; ATPW; FB; HSU79253"
                     /coded_by="XM_011536657.4:174..512"
                     /db_xref="GeneID:27109"
                     /db_xref="HGNC:HGNC:18799"
                     /db_xref="MIM:618579"
ORIGIN      
        1 mmpfgkisqq lcgvkklpws cdsryfwgwl navfnkvdyd rirdvgpdra asewllrcga
       61 mvryhgqerw qkdynhlptg pldkykiqai datdscimsi gfdhmetsni cc
//
LOCUS       XP_047287231             627 aa            linear   PRI 05-AUG-2025
DEFINITION  voltage-gated delayed rectifier potassium channel KCNH5 isoform X1
            [Homo sapiens].
ACCESSION   XP_047287231
VERSION     XP_047287231.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431275.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..627
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..627
                     /product="voltage-gated delayed rectifier potassium
                     channel KCNH5 isoform X1"
                     /calculated_mol_wt=71141
     Region          39..132
                     /region_name="PAS_9"
                     /note="PAS domain; pfam13426"
                     /db_xref="CDD:463873"
     Region          217..>601
                     /region_name="PLN03192"
                     /note="Voltage-dependent potassium channel; Provisional"
                     /db_xref="CDD:215625"
     CDS             1..627
                     /gene="KCNH5"
                     /gene_synonym="DEE112; EAG2; H-EAG2; hEAG2; Kv10.2"
                     /coded_by="XM_047431275.1:273..2156"
                     /db_xref="GeneID:27133"
                     /db_xref="HGNC:HGNC:6254"
                     /db_xref="MIM:605716"
ORIGIN      
        1 mpggkrglva pqntfleniv rrssessfll gnaqivdwpv vysndgfckl sgyhradvmq
       61 ksstcsfmyg eltdkktiek vrqtfdnyes ncfevllykk nrtpvwfymq iapirnehek
      121 vvlflctfkd itlfkqpied dstkgwtkfa rltraltnsr svlqqltpmn ktevvhkhsr
      181 laevlqlgsd ilpqykqeap ktpphiilhy cafkttwdwv ililtfytai mvpynvsfkt
      241 kqnniawlvl dsvvdviflv divlnfhttf vgpggevisd pklirmnylk twfvidllsc
      301 lpydiinafe nvdegisslf sslkvvrllr lgrvarkldh yleygaavlv llvcvfglva
      361 hwlaciwysi gdyevidevt ntiqidswly qlalsigtpy ryntsagiwe ggpskdslyv
      421 sslyftmtsl ttigfgniap ttdvekmfsv ammmvgslly atifgnvtti fqqmyantnr
      481 yhemlnnvrd flklyqvpkg lservmdyiv stwsmskgid tekvlsicpk dmradicvhl
      541 nrkvfnehpa frlasdgclr alavefqtih capgdliyha gesvdalcfv vsgsleviqd
      601 degrvmylet ssgrkpplpm hvrtsgh
//
LOCUS       XP_047287235             282 aa            linear   PRI 05-AUG-2025
DEFINITION  integral membrane protein GPR137C isoform X1 [Homo sapiens].
ACCESSION   XP_047287235
VERSION     XP_047287235.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431279.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..282
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..282
                     /product="integral membrane protein GPR137C isoform X1"
                     /calculated_mol_wt=31384
     Region          <2..216
                     /region_name="7tm_GPCRs"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; cl28897"
                     /db_xref="CDD:475119"
     Region          19..41
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:410550"
     Region          58..80
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:410550"
     Region          101..123
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:410550"
     Region          153..175
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:410550"
     CDS             1..282
                     /gene="GPR137C"
                     /gene_synonym="TM7SF1L2"
                     /coded_by="XM_047431279.1:3412..4260"
                     /db_xref="GeneID:283554"
                     /db_xref="HGNC:HGNC:25445"
ORIGIN      
        1 mvickvrcat eldrhkillh lgfimasllf lvvnltcaml vhgdvpenql kwtvfvrali
       61 ndslfilcai slvcyickit kmssanvyle skgmslcqtv vvgsvvilly ssracynlvv
      121 vtisqdtles pfnygwdnls dkahvedisg eeyivfgmvl flwehvpaws vvlffraqrl
      181 nqnlapagmi nshsyssray ffdnprryds dddlprlgss regslpnsqs lgwygtmtgc
      241 gsssytvtph lngpmtdtap llftcsnldl nnhhslyvtp qn
//
LOCUS       XP_047287236             242 aa            linear   PRI 05-AUG-2025
DEFINITION  integral membrane protein GPR137C isoform X2 [Homo sapiens].
ACCESSION   XP_047287236
VERSION     XP_047287236.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431280.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..242
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..242
                     /product="integral membrane protein GPR137C isoform X2"
                     /calculated_mol_wt=26113
     Region          44..>239
                     /region_name="7tm_GPCRs"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; cl28897"
                     /db_xref="CDD:475119"
     Region          50..72
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:410550"
     Region          84..104
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:410550"
     Region          125..147
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:410550"
     Region          166..188
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:410550"
     Region          205..227
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:410550"
     CDS             1..242
                     /gene="GPR137C"
                     /gene_synonym="TM7SF1L2"
                     /coded_by="XM_047431280.1:313..1041"
                     /db_xref="GeneID:283554"
                     /db_xref="HGNC:HGNC:25445"
ORIGIN      
        1 mrvsvpgpaa aaapaagrep stpgggsggg gavaaasgaa vpgsvqlals vlhallyaal
       61 fafaylqlwr lllyrerrls yqslclflcl lwaalrttlf saafslsgsl pllrppahlh
      121 ffphwllycf psclqfstlc llnlylaevi ckvrcateld rhkillhlgf imasllflvv
      181 nltcamlvhg dvpenqlkwt vfvralinds lfilcaislv cyickitkms sanvyleskl
      241 la
//
LOCUS       XP_024305309             242 aa            linear   PRI 05-AUG-2025
DEFINITION  integral membrane protein GPR137C isoform X3 [Homo sapiens].
ACCESSION   XP_024305309
VERSION     XP_024305309.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449541.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..242
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..242
                     /product="integral membrane protein GPR137C isoform X3"
                     /calculated_mol_wt=26155
     Region          44..>239
                     /region_name="7tm_GPCRs"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; cl28897"
                     /db_xref="CDD:475119"
     Region          50..72
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:410550"
     Region          84..104
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:410550"
     Region          125..147
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:410550"
     Region          166..188
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:410550"
     Region          205..227
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:410550"
     CDS             1..242
                     /gene="GPR137C"
                     /gene_synonym="TM7SF1L2"
                     /coded_by="XM_024449541.2:313..1041"
                     /db_xref="GeneID:283554"
                     /db_xref="HGNC:HGNC:25445"
ORIGIN      
        1 mrvsvpgpaa aaapaagrep stpgggsggg gavaaasgaa vpgsvqlals vlhallyaal
       61 fafaylqlwr lllyrerrls yqslclflcl lwaalrttlf saafslsgsl pllrppahlh
      121 ffphwllycf psclqfstlc llnlylaevi ckvrcateld rhkillhlgf imasllflvv
      181 nltcamlvhg dvpenqlkwt vfvralinds lfilcaislv cyickitkms sanvyleski
      241 il
//
LOCUS       XP_047287237             241 aa            linear   PRI 05-AUG-2025
DEFINITION  integral membrane protein GPR137C isoform X4 [Homo sapiens].
ACCESSION   XP_047287237
VERSION     XP_047287237.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431281.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..241
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..241
                     /product="integral membrane protein GPR137C isoform X4"
                     /calculated_mol_wt=25990
     Region          44..>239
                     /region_name="7tm_GPCRs"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; cl28897"
                     /db_xref="CDD:475119"
     Region          50..72
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:410550"
     Region          84..104
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:410550"
     Region          125..147
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:410550"
     Region          166..188
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:410550"
     Region          205..227
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:410550"
     CDS             1..241
                     /gene="GPR137C"
                     /gene_synonym="TM7SF1L2"
                     /coded_by="XM_047431281.1:313..1038"
                     /db_xref="GeneID:283554"
                     /db_xref="HGNC:HGNC:25445"
ORIGIN      
        1 mrvsvpgpaa aaapaagrep stpgggsggg gavaaasgaa vpgsvqlals vlhallyaal
       61 fafaylqlwr lllyrerrls yqslclflcl lwaalrttlf saafslsgsl pllrppahlh
      121 ffphwllycf psclqfstlc llnlylaevi ckvrcateld rhkillhlgf imasllflvv
      181 nltcamlvhg dvpenqlkwt vfvralinds lfilcaislv cyickitkms sanvylesks
      241 s
//
LOCUS       XP_005267600             592 aa            linear   PRI 05-AUG-2025
DEFINITION  prospero homeobox protein 2 isoform X1 [Homo sapiens].
ACCESSION   XP_005267600
VERSION     XP_005267600.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267543.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..592
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..592
                     /product="prospero homeobox protein 2 isoform X1"
                     /calculated_mol_wt=65455
     Region          439..592
                     /region_name="HPD"
                     /note="Homeo-prospero domain; pfam05044"
                     /db_xref="CDD:461534"
     CDS             1..592
                     /gene="PROX2"
                     /gene_synonym="PROX-2"
                     /coded_by="XM_005267543.5:78..1856"
                     /db_xref="GeneID:283571"
                     /db_xref="HGNC:HGNC:26715"
                     /db_xref="MIM:615094"
ORIGIN      
        1 mdpnsillsp qpqicshlae actegersss ppeldrdspf pwsqvpsssp tdpewfgdeh
       61 iqakrarvet ivrgmclspn plvpgnaqag vsprcpkkar erkrkqnlpt pqgllmpapa
      121 wdqgnrkggp rvreqlhllk qqlrhlqehi lqaakprdta qgpggcgtgk gplsakqgng
      181 cgprpwvvdg dhqqgtskdl sgaekhqese kpsflpsgap asleilrkel travsqavds
      241 vlqkvlldpp ghltqlgrsf qgqvaegrse psppvggack dplalaalpr rvqlqagvpv
      301 gnlslakrld sprypipprm tpkpcqdppa nfpltapshi qenqilsqll ghrynnghws
      361 ssppqdsssq rhpssepalr pwrttkpqpl vlsqqqcplp ftsahleslp llpsvkmeqr
      421 glhavmealp fsllhiqegl npghlkkakl mffftrypss nllkvyfpdv qfnrcitsqm
      481 ikwfsnfref yyiqmeksar qaisdgvtnp kmlvvlrnse lfqalnmhyn kgndfevpdc
      541 fleiasltlq effravsagr dsdpswkkpi ykiiskldsd ipeifksssy pq
//
LOCUS       XP_011534963             263 aa            linear   PRI 05-AUG-2025
DEFINITION  palmitoyltransferase ZDHHC22 isoform X1 [Homo sapiens].
ACCESSION   XP_011534963
VERSION     XP_011534963.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536661.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..263
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..263
                     /product="palmitoyltransferase ZDHHC22 isoform X1"
                     /calculated_mol_wt=28969
     Region          92..218
                     /region_name="DHHC"
                     /note="DHHC palmitoyltransferase; pfam01529"
                     /db_xref="CDD:396215"
     CDS             1..263
                     /gene="ZDHHC22"
                     /gene_synonym="C14orf59"
                     /coded_by="XM_011536661.3:96..887"
                     /db_xref="GeneID:283576"
                     /db_xref="HGNC:HGNC:20106"
ORIGIN      
        1 mlalrllnvv apayflcisl vtfvlqlflf lpsmredpaa arlfspallh galflflsan
       61 algnyvlviq nspddlgacq gasarktpcp spsthfcrvc arvtlrhdhh cfftgncigs
      121 rnmrnfvlfc lytslaclys mvagvayisa vlsisfahpl afltllptsi sqffsgavlg
      181 semfvilmly lwfaiglaca gfcchqllli lrgqtrhqvr kgvavrarpw rknlqevfgk
      241 rwllgllvpm fnvgsesskq qdk
//
LOCUS       XP_016876713             262 aa            linear   PRI 05-AUG-2025
DEFINITION  protein TMED8 isoform X1 [Homo sapiens].
ACCESSION   XP_016876713
VERSION     XP_016876713.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021224.2
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 8% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..262
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..262
                     /product="protein TMED8 isoform X1"
                     /calculated_mol_wt=29317
     Region          122..261
                     /region_name="GPCR_chapero_1"
                     /note="GPCR-chaperone; cl46312"
                     /db_xref="CDD:480652"
     CDS             1..262
                     /gene="TMED8"
                     /gene_synonym="FAM15B"
                     /coded_by="XM_017021224.2:308..1096"
                     /db_xref="GeneID:283578"
                     /db_xref="HGNC:HGNC:18633"
ORIGIN      
        1 mvspvskdat edlrkatgpl eaqalvkqdl lpadqaqvln essvvqmaky qvpqrsgdiv
       61 miqsehtgai dvlsadlesa dllgdhrkvs pplmappciw tfakvkefks klgkeknsrl
      121 vvkrgevvti rvpthpegkr vcwefatddy digfgvyfdw tpvtstditv qvsdssdded
      181 eeeeeeeeie epvpagdver gsrsslrgry gevmpvyrrd shrdvqagsh dypgegiyll
      241 kfdnsysllr nktlyfhiyy ts
//
LOCUS       XP_024305310             301 aa            linear   PRI 05-AUG-2025
DEFINITION  testis-specific serine/threonine-protein kinase 4 isoform X1 [Homo
            sapiens].
ACCESSION   XP_024305310
VERSION     XP_024305310.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449542.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..301
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..301
                     /product="testis-specific serine/threonine-protein kinase
                     4 isoform X1"
                     /calculated_mol_wt=33846
     Region          24..278
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Site            order(31..34,37,39,52,54,86,102..105,158,162..163,165,
                     175..176)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270870"
     CDS             1..301
                     /gene="TSSK4"
                     /gene_synonym="C14orf20; STK22E; TSK-4; TSK4; TSSK5"
                     /coded_by="XM_024449542.2:229..1134"
                     /db_xref="GeneID:283629"
                     /db_xref="HGNC:HGNC:19825"
                     /db_xref="MIM:610711"
ORIGIN      
        1 mgkgdvleaa ptttayhslm deygyevgka ighgsygsvy eafytkqkvm vavkiiskkk
       61 asddylnkfl preiqvmkvl rhkylinfyr aiestsrvyi ilelaqggdv lewiqrygac
      121 seplagkwfs qltlgiaylh sksivhrlmp slsaagrdlk lenllldkwe nvkisdfgfa
      181 kmvpsnqpvg cspsyrqvnc fshlsqtycg sfayacpeil rglpynpfls dtwsmgvily
      241 tlvvahlpfd dtnlkkllre tqkevtfpan htisqeckvq lliacvaqwr ktqarplspl
      301 l
//
LOCUS       XP_011534965             262 aa            linear   PRI 05-AUG-2025
DEFINITION  testis-specific serine/threonine-protein kinase 4 isoform X2 [Homo
            sapiens].
ACCESSION   XP_011534965
VERSION     XP_011534965.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536663.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..262
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..262
                     /product="testis-specific serine/threonine-protein kinase
                     4 isoform X2"
                     /calculated_mol_wt=29887
     Region          <1..227
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..262
                     /gene="TSSK4"
                     /gene_synonym="C14orf20; STK22E; TSK-4; TSK4; TSSK5"
                     /coded_by="XM_011536663.3:113..901"
                     /db_xref="GeneID:283629"
                     /db_xref="HGNC:HGNC:19825"
                     /db_xref="MIM:610711"
ORIGIN      
        1 mkvlrhkyli nfyraiests rvyiilelaq ggdvlewiqr ygacseplag kwfsqltlgi
       61 aylhsksivh rlmpslsaag rdlklenlll dkwenvkisd fgfakmvpsn qpvgcspsyr
      121 qvncfshlsq tycgsfayac peilrglpyn pflsdtwsmg vilytlvvah lpfddtnlkk
      181 llretqkevt fpanhtisqe cknlilqmlr qatkratild iikdswvlkf qpeqptheir
      241 lleamcqlhn ttkqhqslqi tt
//
LOCUS       XP_016876716            1665 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 170 kDa protein B isoform X1 [Homo sapiens].
ACCESSION   XP_016876716
VERSION     XP_016876716.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021227.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1665
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1665
                     /product="centrosomal protein of 170 kDa protein B isoform
                     X1"
                     /calculated_mol_wt=179403
     Region          <111..182
                     /region_name="FHA"
                     /note="forkhead associated (FHA) domain superfamily;
                     cl00062"
                     /db_xref="CDD:469597"
     Region          <419..938
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          918..1601
                     /region_name="CEP170_C"
                     /note="CEP170 C-terminus; pfam15308"
                     /db_xref="CDD:464633"
     CDS             1..1665
                     /gene="CEP170B"
                     /gene_synonym="CEP170R; FAM68C; KIAA0284"
                     /coded_by="XM_017021227.2:747..5744"
                     /db_xref="GeneID:283638"
                     /db_xref="HGNC:HGNC:20362"
                     /db_xref="MIM:620251"
ORIGIN      
        1 malsslaegp agagscpahs dvaswmqrat aaharampgs devgrpqavv rgpghvhipw
       61 grqclsastq gsptryccmc pavagrfvsp airrlklhfq rgsfkrwglw esrsvdkqha
      121 vinydqdrde hwvkdlgsln gtfvndmrip dqkyvtlkln dvirfgydsn myvlervqhr
      181 vpeealkhek ytsqlqvsvk glapkrseal pehtpyceas nprpekgdrr pgteaasyrt
      241 plygqpswwg eddgstlpda qrqgepyper pkgpvqqdge lhgfrapaep qgcsfrreps
      301 yfeiptketp qpsqppevpa hemptkdaea ggggaapvvq shasftiefd dcspgkmkik
      361 dhitkfslrq rrppgkeatp gemvsaetkv adwlvqndps llhrvgpgdd rhstksdlpv
      421 htrtlkghkh edgtqsdsed plakaasaag vpleasgeqv rlqrqikrdp qellhnqqaf
      481 vieffdedtp rkkrsqsfth spsgdpkadk rrgptpadrd rpsvpapvqa ggrssgpqra
      541 gslkrektee rlgspspasr tparpfgsvg rrsrlaqdfm aqclresspa arpspekvpp
      601 vlpapltphg tspvgpptpp paptdpqltk arkqeeddsl sdagtytiet eaqdteveea
      661 rkmidqvfgv lespelsras satfrpvirg drdesddggv aqrmallqef asrplgaapq
      721 aehqglpvpg spggqkwvsr wasladsysd pgltedglgr rggepegslp vrmrrrlpql
      781 pseradspag pessrrsgpg ppeldseqps rlfgqeeldp dslsdasgsd ggrgpepgve
      841 pqdsrrrspq egptwsrgrr sprapgeptp asffigdqng davlsrkpla apgdgeglgq
      901 taqpsppard gvyvsangrm viqlrpgrsp epdgpapafl rqesftkepa sgppapgkpp
      961 hisshpllqd laatraarmd fhsqdthlil ketetalaal earllsnsvd aeceggstpr
     1021 ppedalsgds dvdtastvsl rsgksgpspt tpqplraqke mspsppaaqd pggtalvsar
     1081 eqsserqhhp lgptdmgrge pvrrsairrg hrprgsldwp seergpvlah lpssdvmasn
     1141 hetpeatgag rlgsrrkpaa pppspaaree qsrssassqk gpqaltrsns lstprptras
     1201 rlrrarlgda sdteaadger gslgnpepvg rpaaeqakkl srldilampr kragsftgts
     1261 dpeaaparts fsgrsvelcc asrkptmaea ravsrkaant atttgprqpf srarsgsary
     1321 tsntrrrqqg sdytstseee ygsrhgspkh trshtstatq tpragsssra rsrapgprdt
     1381 dddeeepdpy gfivqtaeia eiarlsqtlv kdvailaqei hdvagdgdtl gssepahsas
     1441 lsnmpstpas tisareelvq ripeaslnfq kvppgslnsr dfdqnmndsc edalanktrp
     1501 rnreevifdn lmlnpvsqls qairentehl aekmkilfqn tgrawedlea rinaenevpi
     1561 lktsnkeiss ilkelrrvqk qlevinaivd psgsldlltg nrslassaqp glgkgrvaaq
     1621 sppspasaea llpalplrnf pqrascgpps lpdptflpda erfli
//
LOCUS       XP_016876717            1630 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 170 kDa protein B isoform X2 [Homo sapiens].
ACCESSION   XP_016876717
VERSION     XP_016876717.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021228.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1630
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1630
                     /product="centrosomal protein of 170 kDa protein B isoform
                     X2"
                     /calculated_mol_wt=175428
     Region          <111..182
                     /region_name="FHA"
                     /note="forkhead associated (FHA) domain superfamily;
                     cl00062"
                     /db_xref="CDD:469597"
     Region          <419..938
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          918..1566
                     /region_name="CEP170_C"
                     /note="CEP170 C-terminus; pfam15308"
                     /db_xref="CDD:464633"
     CDS             1..1630
                     /gene="CEP170B"
                     /gene_synonym="CEP170R; FAM68C; KIAA0284"
                     /coded_by="XM_017021228.2:748..5640"
                     /db_xref="GeneID:283638"
                     /db_xref="HGNC:HGNC:20362"
                     /db_xref="MIM:620251"
ORIGIN      
        1 malsslaegp agagscpahs dvaswmqrat aaharampgs devgrpqavv rgpghvhipw
       61 grqclsastq gsptryccmc pavagrfvsp airrlklhfq rgsfkrwglw esrsvdkqha
      121 vinydqdrde hwvkdlgsln gtfvndmrip dqkyvtlkln dvirfgydsn myvlervqhr
      181 vpeealkhek ytsqlqvsvk glapkrseal pehtpyceas nprpekgdrr pgteaasyrt
      241 plygqpswwg eddgstlpda qrqgepyper pkgpvqqdge lhgfrapaep qgcsfrreps
      301 yfeiptketp qpsqppevpa hemptkdaea ggggaapvvq shasftiefd dcspgkmkik
      361 dhitkfslrq rrppgkeatp gemvsaetkv adwlvqndps llhrvgpgdd rhstksdlpv
      421 htrtlkghkh edgtqsdsed plakaasaag vpleasgeqv rlqrqikrdp qellhnqqaf
      481 vieffdedtp rkkrsqsfth spsgdpkadk rrgptpadrd rpsvpapvqa ggrssgpqra
      541 gslkrektee rlgspspasr tparpfgsvg rrsrlaqdfm aqclresspa arpspekvpp
      601 vlpapltphg tspvgpptpp paptdpqltk arkqeeddsl sdagtytiet eaqdteveea
      661 rkmidqvfgv lespelsras satfrpvirg drdesddggv aqrmallqef asrplgaapq
      721 aehqglpvpg spggqkwvsr wasladsysd pgltedglgr rggepegslp vrmrrrlpql
      781 pseradspag pessrrsgpg ppeldseqps rlfgqeeldp dslsdasgsd ggrgpepgve
      841 pqdsrrrspq egptwsrgrr sprapgeptp asffigdqng davlsrkpla apgdgeglgq
      901 taqpsppard gvyvsangrm viqlrpgrsp epdgpapafl rqesftkepa sgppapgkpp
      961 hisshpllqd laatraarmd fhsqdthlil ketetalaal earllsnsvd aeceggstpr
     1021 ppedalsgds dvdtastvsl rsgksgpspt tpqplraqke mspsppaaqd pggtalvsar
     1081 eqsserqhhp lgptdmgrge pvrrsairrg hrprgsldwp seergpvlah lpssdvmasn
     1141 hetpeatgag rlgsrrkpaa pppspaaree qsrssassqk gpqaltrsns lstprptras
     1201 rlrrarlgda sdteaadger gslgnpepvg rpaaeqakkl srldilampr kragsftgts
     1261 dpeaaparts fsgrsvelcc asrkptmaea ravsrkaant atttgprqpf srarsgsary
     1321 tsttqtprag sssrarsrap gprdtdddee epdpygfivq taeiaeiarl sqtlvkdvai
     1381 laqeihdvag dgdtlgssep ahsaslsnmp stpastisar eelvqripea slnfqkvppg
     1441 slnsrdfdqn mndscedala nktrprnree vifdnlmlnp vsqlsqaire ntehlaekmk
     1501 ilfqntgraw edlearinae nevpilktsn keissilkel rrvqkqlevi naivdpsgsl
     1561 dlltgnrsla ssaqpglgkg rvaaqsppsp asaeallpal plrnfpqras cgppslpdpt
     1621 flpdaerfli
//
LOCUS       XP_005267607            1589 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 170 kDa protein B isoform X3 [Homo sapiens].
ACCESSION   XP_005267607
VERSION     XP_005267607.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267550.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1589
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1589
                     /product="centrosomal protein of 170 kDa protein B isoform
                     X3"
                     /calculated_mol_wt=171558
     Region          1..106
                     /region_name="FHA_Cep170B"
                     /note="forkhead associated (FHA) domain found in
                     centrosomal protein of 170 kDa protein B (Cep170B) and
                     similar proteins; cd22725"
                     /db_xref="CDD:438777"
     Site            order(26..27,40..41,43,62,64..65)
                     /site_type="other"
                     /note="putative phosphopeptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:438777"
     Region          <343..862
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          842..1525
                     /region_name="CEP170_C"
                     /note="CEP170 C-terminus; pfam15308"
                     /db_xref="CDD:464633"
     CDS             1..1589
                     /gene="CEP170B"
                     /gene_synonym="CEP170R; FAM68C; KIAA0284"
                     /coded_by="XM_005267550.5:274..5043"
                     /db_xref="GeneID:283638"
                     /db_xref="HGNC:HGNC:20362"
                     /db_xref="MIM:620251"
ORIGIN      
        1 msatswflvs ssgarhrlpr elifvgreec elmlqsrsvd kqhavinydq drdehwvkdl
       61 gslngtfvnd mripdqkyvt lklndvirfg ydsnmyvler vqhrvpeeal khekytsqlq
      121 vsvkglapkr sealpehtpy ceasnprpek gdrrpgteaa syrtplygqp swwgeddgst
      181 lpdaqrqgep yperpkgpvq qdgelhgfra paepqgcsfr repsyfeipt ketpqpsqpp
      241 evpahemptk daeaggggaa pvvqshasft iefddcspgk mkikdhitkf slrqrrppgk
      301 eatpgemvsa etkvadwlvq ndpsllhrvg pgddrhstks dlpvhtrtlk ghkhedgtqs
      361 dsedplakaa saagvpleas geqvrlqrqi krdpqellhn qqafvieffd edtprkkrsq
      421 sfthspsgdp kadkrrgptp adrdrpsvpa pvqaggrssg pqragslkre kteerlgsps
      481 pasrtparpf gsvgrrsrla qdfmaqclre sspaarpspe kvppvlpapl tphgtspvgp
      541 ptpppaptdp qltkarkqee ddslsdagty tieteaqdte veearkmidq vfgvlespel
      601 srassatfrp virgdrdesd dggvaqrmal lqefasrplg aapqaehqgl pvpgspggqk
      661 wvsrwaslad sysdpglted glgrrggepe gslpvrmrrr lpqlpserad spagpessrr
      721 sgpgppelds eqpsrlfgqe eldpdslsda sgsdggrgpe pgvepqdsrr rspqegptws
      781 rgrrsprapg eptpasffig dqngdavlsr kplaapgdge glgqtaqpsp pardgvyvsa
      841 ngrmviqlrp grspepdgpa paflrqesft kepasgppap gkpphisshp llqdlaatra
      901 armdfhsqdt hlilketeta laalearlls nsvdaecegg stprppedal sgdsdvdtas
      961 tvslrsgksg pspttpqplr aqkemspspp aaqdpggtal vsareqsser qhhplgptdm
     1021 grgepvrrsa irrghrprgs ldwpseergp vlahlpssdv masnhetpea tgagrlgsrr
     1081 kpaapppspa areeqsrssa ssqkgpqalt rsnslstprp trasrlrrar lgdasdteaa
     1141 dgergslgnp epvgrpaaeq akklsrldil amprkragsf tgtsdpeaap artsfsgrsv
     1201 elccasrkpt maearavsrk aantatttgp rqpfsrarsg sarytsntrr rqqgsdytst
     1261 seeeygsrhg spkhtrshts tatqtprags ssrarsrapg prdtdddeee pdpygfivqt
     1321 aeiaeiarls qtlvkdvail aqeihdvagd gdtlgssepa hsaslsnmps tpastisare
     1381 elvqripeas lnfqkvppgs lnsrdfdqnm ndscedalan ktrprnreev ifdnlmlnpv
     1441 sqlsqairen tehlaekmki lfqntgrawe dlearinaen evpilktsnk eissilkelr
     1501 rvqkqlevin aivdpsgsld lltgnrslas saqpglgkgr vaaqsppspa saeallpalp
     1561 lrnfpqrasc gppslpdptf lpdaerfli
//
LOCUS       XP_011534967            1589 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 170 kDa protein B isoform X3 [Homo sapiens].
ACCESSION   XP_011534967
VERSION     XP_011534967.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536665.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1589
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1589
                     /product="centrosomal protein of 170 kDa protein B isoform
                     X3"
                     /calculated_mol_wt=171558
     Region          1..106
                     /region_name="FHA_Cep170B"
                     /note="forkhead associated (FHA) domain found in
                     centrosomal protein of 170 kDa protein B (Cep170B) and
                     similar proteins; cd22725"
                     /db_xref="CDD:438777"
     Site            order(26..27,40..41,43,62,64..65)
                     /site_type="other"
                     /note="putative phosphopeptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:438777"
     Region          <343..862
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          842..1525
                     /region_name="CEP170_C"
                     /note="CEP170 C-terminus; pfam15308"
                     /db_xref="CDD:464633"
     CDS             1..1589
                     /gene="CEP170B"
                     /gene_synonym="CEP170R; FAM68C; KIAA0284"
                     /coded_by="XM_011536665.3:426..5195"
                     /db_xref="GeneID:283638"
                     /db_xref="HGNC:HGNC:20362"
                     /db_xref="MIM:620251"
ORIGIN      
        1 msatswflvs ssgarhrlpr elifvgreec elmlqsrsvd kqhavinydq drdehwvkdl
       61 gslngtfvnd mripdqkyvt lklndvirfg ydsnmyvler vqhrvpeeal khekytsqlq
      121 vsvkglapkr sealpehtpy ceasnprpek gdrrpgteaa syrtplygqp swwgeddgst
      181 lpdaqrqgep yperpkgpvq qdgelhgfra paepqgcsfr repsyfeipt ketpqpsqpp
      241 evpahemptk daeaggggaa pvvqshasft iefddcspgk mkikdhitkf slrqrrppgk
      301 eatpgemvsa etkvadwlvq ndpsllhrvg pgddrhstks dlpvhtrtlk ghkhedgtqs
      361 dsedplakaa saagvpleas geqvrlqrqi krdpqellhn qqafvieffd edtprkkrsq
      421 sfthspsgdp kadkrrgptp adrdrpsvpa pvqaggrssg pqragslkre kteerlgsps
      481 pasrtparpf gsvgrrsrla qdfmaqclre sspaarpspe kvppvlpapl tphgtspvgp
      541 ptpppaptdp qltkarkqee ddslsdagty tieteaqdte veearkmidq vfgvlespel
      601 srassatfrp virgdrdesd dggvaqrmal lqefasrplg aapqaehqgl pvpgspggqk
      661 wvsrwaslad sysdpglted glgrrggepe gslpvrmrrr lpqlpserad spagpessrr
      721 sgpgppelds eqpsrlfgqe eldpdslsda sgsdggrgpe pgvepqdsrr rspqegptws
      781 rgrrsprapg eptpasffig dqngdavlsr kplaapgdge glgqtaqpsp pardgvyvsa
      841 ngrmviqlrp grspepdgpa paflrqesft kepasgppap gkpphisshp llqdlaatra
      901 armdfhsqdt hlilketeta laalearlls nsvdaecegg stprppedal sgdsdvdtas
      961 tvslrsgksg pspttpqplr aqkemspspp aaqdpggtal vsareqsser qhhplgptdm
     1021 grgepvrrsa irrghrprgs ldwpseergp vlahlpssdv masnhetpea tgagrlgsrr
     1081 kpaapppspa areeqsrssa ssqkgpqalt rsnslstprp trasrlrrar lgdasdteaa
     1141 dgergslgnp epvgrpaaeq akklsrldil amprkragsf tgtsdpeaap artsfsgrsv
     1201 elccasrkpt maearavsrk aantatttgp rqpfsrarsg sarytsntrr rqqgsdytst
     1261 seeeygsrhg spkhtrshts tatqtprags ssrarsrapg prdtdddeee pdpygfivqt
     1321 aeiaeiarls qtlvkdvail aqeihdvagd gdtlgssepa hsaslsnmps tpastisare
     1381 elvqripeas lnfqkvppgs lnsrdfdqnm ndscedalan ktrprnreev ifdnlmlnpv
     1441 sqlsqairen tehlaekmki lfqntgrawe dlearinaen evpilktsnk eissilkelr
     1501 rvqkqlevin aivdpsgsld lltgnrslas saqpglgkgr vaaqsppspa saeallpalp
     1561 lrnfpqrasc gppslpdptf lpdaerfli
//
LOCUS       XP_011534968            1589 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 170 kDa protein B isoform X3 [Homo sapiens].
ACCESSION   XP_011534968
VERSION     XP_011534968.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536666.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1589
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1589
                     /product="centrosomal protein of 170 kDa protein B isoform
                     X3"
                     /calculated_mol_wt=171558
     Region          1..106
                     /region_name="FHA_Cep170B"
                     /note="forkhead associated (FHA) domain found in
                     centrosomal protein of 170 kDa protein B (Cep170B) and
                     similar proteins; cd22725"
                     /db_xref="CDD:438777"
     Site            order(26..27,40..41,43,62,64..65)
                     /site_type="other"
                     /note="putative phosphopeptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:438777"
     Region          <343..862
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          842..1525
                     /region_name="CEP170_C"
                     /note="CEP170 C-terminus; pfam15308"
                     /db_xref="CDD:464633"
     CDS             1..1589
                     /gene="CEP170B"
                     /gene_synonym="CEP170R; FAM68C; KIAA0284"
                     /coded_by="XM_011536666.3:749..5518"
                     /db_xref="GeneID:283638"
                     /db_xref="HGNC:HGNC:20362"
                     /db_xref="MIM:620251"
ORIGIN      
        1 msatswflvs ssgarhrlpr elifvgreec elmlqsrsvd kqhavinydq drdehwvkdl
       61 gslngtfvnd mripdqkyvt lklndvirfg ydsnmyvler vqhrvpeeal khekytsqlq
      121 vsvkglapkr sealpehtpy ceasnprpek gdrrpgteaa syrtplygqp swwgeddgst
      181 lpdaqrqgep yperpkgpvq qdgelhgfra paepqgcsfr repsyfeipt ketpqpsqpp
      241 evpahemptk daeaggggaa pvvqshasft iefddcspgk mkikdhitkf slrqrrppgk
      301 eatpgemvsa etkvadwlvq ndpsllhrvg pgddrhstks dlpvhtrtlk ghkhedgtqs
      361 dsedplakaa saagvpleas geqvrlqrqi krdpqellhn qqafvieffd edtprkkrsq
      421 sfthspsgdp kadkrrgptp adrdrpsvpa pvqaggrssg pqragslkre kteerlgsps
      481 pasrtparpf gsvgrrsrla qdfmaqclre sspaarpspe kvppvlpapl tphgtspvgp
      541 ptpppaptdp qltkarkqee ddslsdagty tieteaqdte veearkmidq vfgvlespel
      601 srassatfrp virgdrdesd dggvaqrmal lqefasrplg aapqaehqgl pvpgspggqk
      661 wvsrwaslad sysdpglted glgrrggepe gslpvrmrrr lpqlpserad spagpessrr
      721 sgpgppelds eqpsrlfgqe eldpdslsda sgsdggrgpe pgvepqdsrr rspqegptws
      781 rgrrsprapg eptpasffig dqngdavlsr kplaapgdge glgqtaqpsp pardgvyvsa
      841 ngrmviqlrp grspepdgpa paflrqesft kepasgppap gkpphisshp llqdlaatra
      901 armdfhsqdt hlilketeta laalearlls nsvdaecegg stprppedal sgdsdvdtas
      961 tvslrsgksg pspttpqplr aqkemspspp aaqdpggtal vsareqsser qhhplgptdm
     1021 grgepvrrsa irrghrprgs ldwpseergp vlahlpssdv masnhetpea tgagrlgsrr
     1081 kpaapppspa areeqsrssa ssqkgpqalt rsnslstprp trasrlrrar lgdasdteaa
     1141 dgergslgnp epvgrpaaeq akklsrldil amprkragsf tgtsdpeaap artsfsgrsv
     1201 elccasrkpt maearavsrk aantatttgp rqpfsrarsg sarytsntrr rqqgsdytst
     1261 seeeygsrhg spkhtrshts tatqtprags ssrarsrapg prdtdddeee pdpygfivqt
     1321 aeiaeiarls qtlvkdvail aqeihdvagd gdtlgssepa hsaslsnmps tpastisare
     1381 elvqripeas lnfqkvppgs lnsrdfdqnm ndscedalan ktrprnreev ifdnlmlnpv
     1441 sqlsqairen tehlaekmki lfqntgrawe dlearinaen evpilktsnk eissilkelr
     1501 rvqkqlevin aivdpsgsld lltgnrslas saqpglgkgr vaaqsppspa saeallpalp
     1561 lrnfpqrasc gppslpdptf lpdaerfli
//
LOCUS       XP_047287242            1589 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 170 kDa protein B isoform X3 [Homo sapiens].
ACCESSION   XP_047287242
VERSION     XP_047287242.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431286.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1589
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1589
                     /product="centrosomal protein of 170 kDa protein B isoform
                     X3"
                     /calculated_mol_wt=171558
     Region          1..106
                     /region_name="FHA_Cep170B"
                     /note="forkhead associated (FHA) domain found in
                     centrosomal protein of 170 kDa protein B (Cep170B) and
                     similar proteins; cd22725"
                     /db_xref="CDD:438777"
     Site            order(26..27,40..41,43,62,64..65)
                     /site_type="other"
                     /note="putative phosphopeptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:438777"
     Region          <343..862
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          842..1525
                     /region_name="CEP170_C"
                     /note="CEP170 C-terminus; pfam15308"
                     /db_xref="CDD:464633"
     CDS             1..1589
                     /gene="CEP170B"
                     /gene_synonym="CEP170R; FAM68C; KIAA0284"
                     /coded_by="XM_047431286.1:901..5670"
                     /db_xref="GeneID:283638"
                     /db_xref="HGNC:HGNC:20362"
                     /db_xref="MIM:620251"
ORIGIN      
        1 msatswflvs ssgarhrlpr elifvgreec elmlqsrsvd kqhavinydq drdehwvkdl
       61 gslngtfvnd mripdqkyvt lklndvirfg ydsnmyvler vqhrvpeeal khekytsqlq
      121 vsvkglapkr sealpehtpy ceasnprpek gdrrpgteaa syrtplygqp swwgeddgst
      181 lpdaqrqgep yperpkgpvq qdgelhgfra paepqgcsfr repsyfeipt ketpqpsqpp
      241 evpahemptk daeaggggaa pvvqshasft iefddcspgk mkikdhitkf slrqrrppgk
      301 eatpgemvsa etkvadwlvq ndpsllhrvg pgddrhstks dlpvhtrtlk ghkhedgtqs
      361 dsedplakaa saagvpleas geqvrlqrqi krdpqellhn qqafvieffd edtprkkrsq
      421 sfthspsgdp kadkrrgptp adrdrpsvpa pvqaggrssg pqragslkre kteerlgsps
      481 pasrtparpf gsvgrrsrla qdfmaqclre sspaarpspe kvppvlpapl tphgtspvgp
      541 ptpppaptdp qltkarkqee ddslsdagty tieteaqdte veearkmidq vfgvlespel
      601 srassatfrp virgdrdesd dggvaqrmal lqefasrplg aapqaehqgl pvpgspggqk
      661 wvsrwaslad sysdpglted glgrrggepe gslpvrmrrr lpqlpserad spagpessrr
      721 sgpgppelds eqpsrlfgqe eldpdslsda sgsdggrgpe pgvepqdsrr rspqegptws
      781 rgrrsprapg eptpasffig dqngdavlsr kplaapgdge glgqtaqpsp pardgvyvsa
      841 ngrmviqlrp grspepdgpa paflrqesft kepasgppap gkpphisshp llqdlaatra
      901 armdfhsqdt hlilketeta laalearlls nsvdaecegg stprppedal sgdsdvdtas
      961 tvslrsgksg pspttpqplr aqkemspspp aaqdpggtal vsareqsser qhhplgptdm
     1021 grgepvrrsa irrghrprgs ldwpseergp vlahlpssdv masnhetpea tgagrlgsrr
     1081 kpaapppspa areeqsrssa ssqkgpqalt rsnslstprp trasrlrrar lgdasdteaa
     1141 dgergslgnp epvgrpaaeq akklsrldil amprkragsf tgtsdpeaap artsfsgrsv
     1201 elccasrkpt maearavsrk aantatttgp rqpfsrarsg sarytsntrr rqqgsdytst
     1261 seeeygsrhg spkhtrshts tatqtprags ssrarsrapg prdtdddeee pdpygfivqt
     1321 aeiaeiarls qtlvkdvail aqeihdvagd gdtlgssepa hsaslsnmps tpastisare
     1381 elvqripeas lnfqkvppgs lnsrdfdqnm ndscedalan ktrprnreev ifdnlmlnpv
     1441 sqlsqairen tehlaekmki lfqntgrawe dlearinaen evpilktsnk eissilkelr
     1501 rvqkqlevin aivdpsgsld lltgnrslas saqpglgkgr vaaqsppspa saeallpalp
     1561 lrnfpqrasc gppslpdptf lpdaerfli
//
LOCUS       XP_047287243            1589 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 170 kDa protein B isoform X3 [Homo sapiens].
ACCESSION   XP_047287243
VERSION     XP_047287243.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431287.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1589
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1589
                     /product="centrosomal protein of 170 kDa protein B isoform
                     X3"
                     /calculated_mol_wt=171558
     Region          1..106
                     /region_name="FHA_Cep170B"
                     /note="forkhead associated (FHA) domain found in
                     centrosomal protein of 170 kDa protein B (Cep170B) and
                     similar proteins; cd22725"
                     /db_xref="CDD:438777"
     Site            order(26..27,40..41,43,62,64..65)
                     /site_type="other"
                     /note="putative phosphopeptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:438777"
     Region          <343..862
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          842..1525
                     /region_name="CEP170_C"
                     /note="CEP170 C-terminus; pfam15308"
                     /db_xref="CDD:464633"
     CDS             1..1589
                     /gene="CEP170B"
                     /gene_synonym="CEP170R; FAM68C; KIAA0284"
                     /coded_by="XM_047431287.1:150..4919"
                     /db_xref="GeneID:283638"
                     /db_xref="HGNC:HGNC:20362"
                     /db_xref="MIM:620251"
ORIGIN      
        1 msatswflvs ssgarhrlpr elifvgreec elmlqsrsvd kqhavinydq drdehwvkdl
       61 gslngtfvnd mripdqkyvt lklndvirfg ydsnmyvler vqhrvpeeal khekytsqlq
      121 vsvkglapkr sealpehtpy ceasnprpek gdrrpgteaa syrtplygqp swwgeddgst
      181 lpdaqrqgep yperpkgpvq qdgelhgfra paepqgcsfr repsyfeipt ketpqpsqpp
      241 evpahemptk daeaggggaa pvvqshasft iefddcspgk mkikdhitkf slrqrrppgk
      301 eatpgemvsa etkvadwlvq ndpsllhrvg pgddrhstks dlpvhtrtlk ghkhedgtqs
      361 dsedplakaa saagvpleas geqvrlqrqi krdpqellhn qqafvieffd edtprkkrsq
      421 sfthspsgdp kadkrrgptp adrdrpsvpa pvqaggrssg pqragslkre kteerlgsps
      481 pasrtparpf gsvgrrsrla qdfmaqclre sspaarpspe kvppvlpapl tphgtspvgp
      541 ptpppaptdp qltkarkqee ddslsdagty tieteaqdte veearkmidq vfgvlespel
      601 srassatfrp virgdrdesd dggvaqrmal lqefasrplg aapqaehqgl pvpgspggqk
      661 wvsrwaslad sysdpglted glgrrggepe gslpvrmrrr lpqlpserad spagpessrr
      721 sgpgppelds eqpsrlfgqe eldpdslsda sgsdggrgpe pgvepqdsrr rspqegptws
      781 rgrrsprapg eptpasffig dqngdavlsr kplaapgdge glgqtaqpsp pardgvyvsa
      841 ngrmviqlrp grspepdgpa paflrqesft kepasgppap gkpphisshp llqdlaatra
      901 armdfhsqdt hlilketeta laalearlls nsvdaecegg stprppedal sgdsdvdtas
      961 tvslrsgksg pspttpqplr aqkemspspp aaqdpggtal vsareqsser qhhplgptdm
     1021 grgepvrrsa irrghrprgs ldwpseergp vlahlpssdv masnhetpea tgagrlgsrr
     1081 kpaapppspa areeqsrssa ssqkgpqalt rsnslstprp trasrlrrar lgdasdteaa
     1141 dgergslgnp epvgrpaaeq akklsrldil amprkragsf tgtsdpeaap artsfsgrsv
     1201 elccasrkpt maearavsrk aantatttgp rqpfsrarsg sarytsntrr rqqgsdytst
     1261 seeeygsrhg spkhtrshts tatqtprags ssrarsrapg prdtdddeee pdpygfivqt
     1321 aeiaeiarls qtlvkdvail aqeihdvagd gdtlgssepa hsaslsnmps tpastisare
     1381 elvqripeas lnfqkvppgs lnsrdfdqnm ndscedalan ktrprnreev ifdnlmlnpv
     1441 sqlsqairen tehlaekmki lfqntgrawe dlearinaen evpilktsnk eissilkelr
     1501 rvqkqlevin aivdpsgsld lltgnrslas saqpglgkgr vaaqsppspa saeallpalp
     1561 lrnfpqrasc gppslpdptf lpdaerfli
//
LOCUS       XP_011534969            1010 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 170 kDa protein B isoform X4 [Homo sapiens].
ACCESSION   XP_011534969
VERSION     XP_011534969.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536667.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1010
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1010
                     /product="centrosomal protein of 170 kDa protein B isoform
                     X4"
                     /calculated_mol_wt=107440
     Region          64..>303
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          263..946
                     /region_name="CEP170_C"
                     /note="CEP170 C-terminus; pfam15308"
                     /db_xref="CDD:464633"
     CDS             1..1010
                     /gene="CEP170B"
                     /gene_synonym="CEP170R; FAM68C; KIAA0284"
                     /coded_by="XM_011536667.3:140..3172"
                     /db_xref="GeneID:283638"
                     /db_xref="HGNC:HGNC:20362"
                     /db_xref="MIM:620251"
ORIGIN      
        1 msrppatlan qvfgvlespe lsrassatfr pvirgdrdes ddggvaqrma llqefasrpl
       61 gaapqaehqg lpvpgspggq kwvsrwasla dsysdpglte dglgrrggep egslpvrmrr
      121 rlpqlpsera dspagpessr rsgpgppeld seqpsrlfgq eeldpdslsd asgsdggrgp
      181 epgvepqdsr rrspqegptw srgrrsprap geptpasffi gdqngdavls rkplaapgdg
      241 eglgqtaqps ppardgvyvs angrmviqlr pgrspepdgp apaflrqesf tkepasgppa
      301 pgkpphissh pllqdlaatr aarmdfhsqd thlilketet alaalearll snsvdaeceg
      361 gstprppeda lsgdsdvdta stvslrsgks gpspttpqpl raqkemspsp paaqdpggta
      421 lvsareqsse rqhhplgptd mgrgepvrrs airrghrprg sldwpseerg pvlahlpssd
      481 vmasnhetpe atgagrlgsr rkpaapppsp aareeqsrss assqkgpqal trsnslstpr
      541 ptrasrlrra rlgdasdtea adgergslgn pepvgrpaae qakklsrldi lamprkrags
      601 ftgtsdpeaa partsfsgrs velccasrkp tmaearavsr kaantatttg prqpfsrars
      661 gsarytsntr rrqqgsdyts tseeeygsrh gspkhtrsht statqtprag sssrarsrap
      721 gprdtdddee epdpygfivq taeiaeiarl sqtlvkdvai laqeihdvag dgdtlgssep
      781 ahsaslsnmp stpastisar eelvqripea slnfqkvppg slnsrdfdqn mndscedala
      841 nktrprnree vifdnlmlnp vsqlsqaire ntehlaekmk ilfqntgraw edlearinae
      901 nevpilktsn keissilkel rrvqkqlevi naivdpsgsl dlltgnrsla ssaqpglgkg
      961 rvaaqsppsp asaeallpal plrnfpqras cgppslpdpt flpdaerfli
//
LOCUS       XP_016876718             924 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 170 kDa protein B isoform X5 [Homo sapiens].
ACCESSION   XP_016876718
VERSION     XP_016876718.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021229.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..924
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..924
                     /product="centrosomal protein of 170 kDa protein B isoform
                     X5"
                     /calculated_mol_wt=100038
     Region          <111..182
                     /region_name="FHA"
                     /note="forkhead associated (FHA) domain superfamily;
                     cl00062"
                     /db_xref="CDD:469597"
     CDS             1..924
                     /gene="CEP170B"
                     /gene_synonym="CEP170R; FAM68C; KIAA0284"
                     /coded_by="XM_017021229.2:753..3527"
                     /db_xref="GeneID:283638"
                     /db_xref="HGNC:HGNC:20362"
                     /db_xref="MIM:620251"
ORIGIN      
        1 malsslaegp agagscpahs dvaswmqrat aaharampgs devgrpqavv rgpghvhipw
       61 grqclsastq gsptryccmc pavagrfvsp airrlklhfq rgsfkrwglw esrsvdkqha
      121 vinydqdrde hwvkdlgsln gtfvndmrip dqkyvtlkln dvirfgydsn myvlervqhr
      181 vpeealkhek ytsqlqvsvk glapkrseal pehtpyceas nprpekgdrr pgteaasyrt
      241 plygqpswwg eddgstlpda qrqgepyper pkgpvqqdge lhgfrapaep qgcsfrreps
      301 yfeiptketp qpsqppevpa hemptkdaea ggggaapvvq shasftiefd dcspgkmkik
      361 dhitkfslrq rrppgkeatp gemvsaetkv adwlvqndps llhrvgpgdd rhstksdlpv
      421 htrtlkghkh edgtqsdsed plakaasaag vpleasgeqv rlqrqikrdp qellhnqqaf
      481 vieffdedtp rkkrsqsfth spsgdpkadk rrgptpadrd rpsvpapvqa ggrssgpqra
      541 gslkrektee rlgspspasr tparpfgsvg rrsrlaqdfm aqclresspa arpspekvpp
      601 vlpapltphg tspvgpptpp paptdpqltk arkqeeddsl sdagtytiet eaqdteveea
      661 rkmidqgwvr ipsacpadsq aacpghqplw ptrslgcwsp lnspghlrpp faqssegtem
      721 slmtgawpsg wrycrslppg hwvrpprrst rasrcraplg vrsgcpagpa wltatqtras
      781 qrmawdveag srrgpclcac gdgslscpvr gltalraqra aggvglghrs wtvsspaass
      841 arrswiltas ampvgrtgae apsqgwshrt adagaprrgp rgagvgahqg ppgsqlppls
      901 slgtrmgtlc ylgnrlrlqg mgra
//
LOCUS       XP_016876719             903 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 170 kDa protein B isoform X6 [Homo sapiens].
ACCESSION   XP_016876719
VERSION     XP_016876719.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021230.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..903
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..903
                     /product="centrosomal protein of 170 kDa protein B isoform
                     X6"
                     /calculated_mol_wt=97751
     Region          <111..182
                     /region_name="FHA"
                     /note="forkhead associated (FHA) domain superfamily;
                     cl00062"
                     /db_xref="CDD:469597"
     CDS             1..903
                     /gene="CEP170B"
                     /gene_synonym="CEP170R; FAM68C; KIAA0284"
                     /coded_by="XM_017021230.2:752..3463"
                     /db_xref="GeneID:283638"
                     /db_xref="HGNC:HGNC:20362"
                     /db_xref="MIM:620251"
ORIGIN      
        1 malsslaegp agagscpahs dvaswmqrat aaharampgs devgrpqavv rgpghvhipw
       61 grqclsastq gsptryccmc pavagrfvsp airrlklhfq rgsfkrwglw esrsvdkqha
      121 vinydqdrde hwvkdlgsln gtfvndmrip dqkyvtlkln dvirfgydsn myvlervqhr
      181 vpeealkhek ytsqlqvsvk glapkrseal pehtpyceas nprpekgdrr pgteaasyrt
      241 plygqpswwg eddgstlpda qrqgepyper pkgpvqqdge lhgfrapaep qgcsfrreps
      301 yfeiptketp qpsqppevpa hemptkdaea ggggaapvvq shasftiefd dcspgkmkik
      361 dhitkfslrq rrppgkeatp gemvsaetkv adwlvqndps llhrvgpgdd rhstksdlpv
      421 htrtlkghkh edgtqsdsed plakaasaag vpleasgeqv rlqrqikrdp qellhnqqaf
      481 vieffdedtp rkkrsqsfth spsgdpkadk rrgptpadrd rpsvpapvqa ggrssgpqra
      541 gslkrektee rlgspspasr tparpfgsvg rrsrlaqdfm aqclresspa arpspekvpp
      601 vlpapltphg tspvgpptpp paptdpqltk arkqeeddsl sdagtytiet eaqdteveea
      661 rkmidqvqps geslgcwspl nspghlrppf aqssegtems lmtgawpsgw rycrslppgh
      721 wvrpprrstr asrcraplgv rsgcpagpaw ltatqtrasq rmawdveags rrgpclcacg
      781 dgslscpvrg ltalraqraa ggvglghrsw tvsspaassa rrswiltasa mpvgrtgaea
      841 psqgwshrta dagaprrgpr gagvgahqgp pgsqlpplss lgtrmgtlcy lgnrlrlqgm
      901 gra
//
LOCUS       XP_047287249             222 aa            linear   PRI 05-AUG-2025
DEFINITION  syntaxin-binding protein 6 isoform X1 [Homo sapiens].
ACCESSION   XP_047287249
VERSION     XP_047287249.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431293.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 29% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..222
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..222
                     /product="syntaxin-binding protein 6 isoform X1"
                     /calculated_mol_wt=24700
     Region          14..143
                     /region_name="PH-STXBP6"
                     /note="PH-like domain of Syntaxin binding protein 6;
                     cd14681"
                     /db_xref="CDD:270200"
     Region          161..222
                     /region_name="R-SNARE_STXBP6"
                     /note="SNARE domain of STXBP6; cd15892"
                     /db_xref="CDD:277245"
     Site            order(162..163,166..167,169..171,173..178,180..182,
                     184..185,187..188,191..192,194..199,201..203,205..206,
                     208..213,215..216)
                     /site_type="other"
                     /note="heterotetramer interface [polypeptide binding]"
                     /db_xref="CDD:277245"
     Site            188
                     /site_type="other"
                     /note="zero layer"
                     /db_xref="CDD:277245"
     CDS             1..222
                     /gene="STXBP6"
                     /gene_synonym="amisyn; HSPC156"
                     /coded_by="XM_047431293.1:470..1138"
                     /db_xref="GeneID:29091"
                     /db_xref="HGNC:HGNC:19666"
                     /db_xref="MIM:607958"
ORIGIN      
        1 mnslravltc stmsaksais keifaplder mlgavqvkrr tkkkipflat ggqgeyltyi
       61 clsvtnkkpt qasitkvkqf egstsfvrrs qwmleqlrqv ngidpngdsa efdllfenaf
      121 dqwvastase kctffqilhh tcqryltdrk pefincqski mggnsilhsa adsvtsavqk
      181 asqalnerge rlgraeekte dlknsaqqfa etahklamkh kc
//
LOCUS       XP_047287250             210 aa            linear   PRI 05-AUG-2025
DEFINITION  syntaxin-binding protein 6 isoform X2 [Homo sapiens].
ACCESSION   XP_047287250
VERSION     XP_047287250.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431294.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..210
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..210
                     /product="syntaxin-binding protein 6 isoform X2"
                     /calculated_mol_wt=23423
     Region          2..131
                     /region_name="PH-STXBP6"
                     /note="PH-like domain of Syntaxin binding protein 6;
                     cd14681"
                     /db_xref="CDD:270200"
     Region          149..210
                     /region_name="R-SNARE_STXBP6"
                     /note="SNARE domain of STXBP6; cd15892"
                     /db_xref="CDD:277245"
     Site            order(150..151,154..155,157..159,161..166,168..170,
                     172..173,175..176,179..180,182..187,189..191,193..194,
                     196..201,203..204)
                     /site_type="other"
                     /note="heterotetramer interface [polypeptide binding]"
                     /db_xref="CDD:277245"
     Site            176
                     /site_type="other"
                     /note="zero layer"
                     /db_xref="CDD:277245"
     CDS             1..210
                     /gene="STXBP6"
                     /gene_synonym="amisyn; HSPC156"
                     /coded_by="XM_047431294.1:419..1051"
                     /db_xref="GeneID:29091"
                     /db_xref="HGNC:HGNC:19666"
                     /db_xref="MIM:607958"
ORIGIN      
        1 msaksaiske ifaplderml gavqvkrrtk kkipflatgg qgeyltyicl svtnkkptqa
       61 sitkvkqfeg stsfvrrsqw mleqlrqvng idpngdsaef dllfenafdq wvastasekc
      121 tffqilhhtc qryltdrkpe fincqskimg gnsilhsaad svtsavqkas qalnergerl
      181 graeektedl knsaqqfaet ahklamkhkc
//
LOCUS       XP_047287251             210 aa            linear   PRI 05-AUG-2025
DEFINITION  syntaxin-binding protein 6 isoform X2 [Homo sapiens].
ACCESSION   XP_047287251
VERSION     XP_047287251.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431295.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..210
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..210
                     /product="syntaxin-binding protein 6 isoform X2"
                     /calculated_mol_wt=23423
     Region          2..131
                     /region_name="PH-STXBP6"
                     /note="PH-like domain of Syntaxin binding protein 6;
                     cd14681"
                     /db_xref="CDD:270200"
     Region          149..210
                     /region_name="R-SNARE_STXBP6"
                     /note="SNARE domain of STXBP6; cd15892"
                     /db_xref="CDD:277245"
     Site            order(150..151,154..155,157..159,161..166,168..170,
                     172..173,175..176,179..180,182..187,189..191,193..194,
                     196..201,203..204)
                     /site_type="other"
                     /note="heterotetramer interface [polypeptide binding]"
                     /db_xref="CDD:277245"
     Site            176
                     /site_type="other"
                     /note="zero layer"
                     /db_xref="CDD:277245"
     CDS             1..210
                     /gene="STXBP6"
                     /gene_synonym="amisyn; HSPC156"
                     /coded_by="XM_047431295.1:312..944"
                     /db_xref="GeneID:29091"
                     /db_xref="HGNC:HGNC:19666"
                     /db_xref="MIM:607958"
ORIGIN      
        1 msaksaiske ifaplderml gavqvkrrtk kkipflatgg qgeyltyicl svtnkkptqa
       61 sitkvkqfeg stsfvrrsqw mleqlrqvng idpngdsaef dllfenafdq wvastasekc
      121 tffqilhhtc qryltdrkpe fincqskimg gnsilhsaad svtsavqkas qalnergerl
      181 graeektedl knsaqqfaet ahklamkhkc
//
LOCUS       XP_024305315             210 aa            linear   PRI 05-AUG-2025
DEFINITION  syntaxin-binding protein 6 isoform X2 [Homo sapiens].
ACCESSION   XP_024305315
VERSION     XP_024305315.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449547.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..210
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..210
                     /product="syntaxin-binding protein 6 isoform X2"
                     /calculated_mol_wt=23423
     Region          2..131
                     /region_name="PH-STXBP6"
                     /note="PH-like domain of Syntaxin binding protein 6;
                     cd14681"
                     /db_xref="CDD:270200"
     Region          149..210
                     /region_name="R-SNARE_STXBP6"
                     /note="SNARE domain of STXBP6; cd15892"
                     /db_xref="CDD:277245"
     Site            order(150..151,154..155,157..159,161..166,168..170,
                     172..173,175..176,179..180,182..187,189..191,193..194,
                     196..201,203..204)
                     /site_type="other"
                     /note="heterotetramer interface [polypeptide binding]"
                     /db_xref="CDD:277245"
     Site            176
                     /site_type="other"
                     /note="zero layer"
                     /db_xref="CDD:277245"
     CDS             1..210
                     /gene="STXBP6"
                     /gene_synonym="amisyn; HSPC156"
                     /coded_by="XM_024449547.2:225..857"
                     /db_xref="GeneID:29091"
                     /db_xref="HGNC:HGNC:19666"
                     /db_xref="MIM:607958"
ORIGIN      
        1 msaksaiske ifaplderml gavqvkrrtk kkipflatgg qgeyltyicl svtnkkptqa
       61 sitkvkqfeg stsfvrrsqw mleqlrqvng idpngdsaef dllfenafdq wvastasekc
      121 tffqilhhtc qryltdrkpe fincqskimg gnsilhsaad svtsavqkas qalnergerl
      181 graeektedl knsaqqfaet ahklamkhkc
//
LOCUS       XP_047287252             210 aa            linear   PRI 05-AUG-2025
DEFINITION  syntaxin-binding protein 6 isoform X2 [Homo sapiens].
ACCESSION   XP_047287252
VERSION     XP_047287252.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431296.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..210
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..210
                     /product="syntaxin-binding protein 6 isoform X2"
                     /calculated_mol_wt=23423
     Region          2..131
                     /region_name="PH-STXBP6"
                     /note="PH-like domain of Syntaxin binding protein 6;
                     cd14681"
                     /db_xref="CDD:270200"
     Region          149..210
                     /region_name="R-SNARE_STXBP6"
                     /note="SNARE domain of STXBP6; cd15892"
                     /db_xref="CDD:277245"
     Site            order(150..151,154..155,157..159,161..166,168..170,
                     172..173,175..176,179..180,182..187,189..191,193..194,
                     196..201,203..204)
                     /site_type="other"
                     /note="heterotetramer interface [polypeptide binding]"
                     /db_xref="CDD:277245"
     Site            176
                     /site_type="other"
                     /note="zero layer"
                     /db_xref="CDD:277245"
     CDS             1..210
                     /gene="STXBP6"
                     /gene_synonym="amisyn; HSPC156"
                     /coded_by="XM_047431296.1:332..964"
                     /db_xref="GeneID:29091"
                     /db_xref="HGNC:HGNC:19666"
                     /db_xref="MIM:607958"
ORIGIN      
        1 msaksaiske ifaplderml gavqvkrrtk kkipflatgg qgeyltyicl svtnkkptqa
       61 sitkvkqfeg stsfvrrsqw mleqlrqvng idpngdsaef dllfenafdq wvastasekc
      121 tffqilhhtc qryltdrkpe fincqskimg gnsilhsaad svtsavqkas qalnergerl
      181 graeektedl knsaqqfaet ahklamkhkc
//
LOCUS       XP_047287254             210 aa            linear   PRI 05-AUG-2025
DEFINITION  syntaxin-binding protein 6 isoform X2 [Homo sapiens].
ACCESSION   XP_047287254
VERSION     XP_047287254.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431298.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..210
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..210
                     /product="syntaxin-binding protein 6 isoform X2"
                     /calculated_mol_wt=23423
     Region          2..131
                     /region_name="PH-STXBP6"
                     /note="PH-like domain of Syntaxin binding protein 6;
                     cd14681"
                     /db_xref="CDD:270200"
     Region          149..210
                     /region_name="R-SNARE_STXBP6"
                     /note="SNARE domain of STXBP6; cd15892"
                     /db_xref="CDD:277245"
     Site            order(150..151,154..155,157..159,161..166,168..170,
                     172..173,175..176,179..180,182..187,189..191,193..194,
                     196..201,203..204)
                     /site_type="other"
                     /note="heterotetramer interface [polypeptide binding]"
                     /db_xref="CDD:277245"
     Site            176
                     /site_type="other"
                     /note="zero layer"
                     /db_xref="CDD:277245"
     CDS             1..210
                     /gene="STXBP6"
                     /gene_synonym="amisyn; HSPC156"
                     /coded_by="XM_047431298.1:343..975"
                     /db_xref="GeneID:29091"
                     /db_xref="HGNC:HGNC:19666"
                     /db_xref="MIM:607958"
ORIGIN      
        1 msaksaiske ifaplderml gavqvkrrtk kkipflatgg qgeyltyicl svtnkkptqa
       61 sitkvkqfeg stsfvrrsqw mleqlrqvng idpngdsaef dllfenafdq wvastasekc
      121 tffqilhhtc qryltdrkpe fincqskimg gnsilhsaad svtsavqkas qalnergerl
      181 graeektedl knsaqqfaet ahklamkhkc
//
LOCUS       XP_016876730             210 aa            linear   PRI 05-AUG-2025
DEFINITION  syntaxin-binding protein 6 isoform X2 [Homo sapiens].
ACCESSION   XP_016876730
VERSION     XP_016876730.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021241.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..210
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..210
                     /product="syntaxin-binding protein 6 isoform X2"
                     /calculated_mol_wt=23423
     Region          2..131
                     /region_name="PH-STXBP6"
                     /note="PH-like domain of Syntaxin binding protein 6;
                     cd14681"
                     /db_xref="CDD:270200"
     Region          149..210
                     /region_name="R-SNARE_STXBP6"
                     /note="SNARE domain of STXBP6; cd15892"
                     /db_xref="CDD:277245"
     Site            order(150..151,154..155,157..159,161..166,168..170,
                     172..173,175..176,179..180,182..187,189..191,193..194,
                     196..201,203..204)
                     /site_type="other"
                     /note="heterotetramer interface [polypeptide binding]"
                     /db_xref="CDD:277245"
     Site            176
                     /site_type="other"
                     /note="zero layer"
                     /db_xref="CDD:277245"
     CDS             1..210
                     /gene="STXBP6"
                     /gene_synonym="amisyn; HSPC156"
                     /coded_by="XM_017021241.2:54..686"
                     /db_xref="GeneID:29091"
                     /db_xref="HGNC:HGNC:19666"
                     /db_xref="MIM:607958"
ORIGIN      
        1 msaksaiske ifaplderml gavqvkrrtk kkipflatgg qgeyltyicl svtnkkptqa
       61 sitkvkqfeg stsfvrrsqw mleqlrqvng idpngdsaef dllfenafdq wvastasekc
      121 tffqilhhtc qryltdrkpe fincqskimg gnsilhsaad svtsavqkas qalnergerl
      181 graeektedl knsaqqfaet ahklamkhkc
//
LOCUS       XP_006720184             130 aa            linear   PRI 05-AUG-2025
DEFINITION  syntaxin-binding protein 6 isoform X3 [Homo sapiens].
ACCESSION   XP_006720184
VERSION     XP_006720184.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720121.5
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 27% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..130
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..130
                     /product="syntaxin-binding protein 6 isoform X3"
                     /calculated_mol_wt=14472
     Region          <1..51
                     /region_name="PH-like"
                     /note="Pleckstrin homology-like domain; cl17171"
                     /db_xref="CDD:473070"
     Region          69..130
                     /region_name="SNARE"
                     /note="SNARE motif; cl22856"
                     /db_xref="CDD:473982"
     Site            order(93,100,103)
                     /site_type="other"
                     /note="flanking leucine-zipper layers"
                     /db_xref="CDD:277192"
     Site            96
                     /site_type="active"
                     /note="zero layer [active]"
                     /db_xref="CDD:277192"
     CDS             1..130
                     /gene="STXBP6"
                     /gene_synonym="amisyn; HSPC156"
                     /coded_by="XM_006720121.5:505..897"
                     /db_xref="GeneID:29091"
                     /db_xref="HGNC:HGNC:19666"
                     /db_xref="MIM:607958"
ORIGIN      
        1 mleqlrqvng idpngdsaef dllfenafdq wvastasekc tffqilhhtc qryltdrkpe
       61 fincqskimg gnsilhsaad svtsavqkas qalnergerl graeektedl knsaqqfaet
      121 ahklamkhkc
//
LOCUS       XP_047287255             130 aa            linear   PRI 05-AUG-2025
DEFINITION  syntaxin-binding protein 6 isoform X3 [Homo sapiens].
ACCESSION   XP_047287255
VERSION     XP_047287255.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431299.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 29% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..130
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..130
                     /product="syntaxin-binding protein 6 isoform X3"
                     /calculated_mol_wt=14472
     Region          <1..51
                     /region_name="PH-like"
                     /note="Pleckstrin homology-like domain; cl17171"
                     /db_xref="CDD:473070"
     Region          69..130
                     /region_name="SNARE"
                     /note="SNARE motif; cl22856"
                     /db_xref="CDD:473982"
     Site            order(93,100,103)
                     /site_type="other"
                     /note="flanking leucine-zipper layers"
                     /db_xref="CDD:277192"
     Site            96
                     /site_type="active"
                     /note="zero layer [active]"
                     /db_xref="CDD:277192"
     CDS             1..130
                     /gene="STXBP6"
                     /gene_synonym="amisyn; HSPC156"
                     /coded_by="XM_047431299.1:343..735"
                     /db_xref="GeneID:29091"
                     /db_xref="HGNC:HGNC:19666"
                     /db_xref="MIM:607958"
ORIGIN      
        1 mleqlrqvng idpngdsaef dllfenafdq wvastasekc tffqilhhtc qryltdrkpe
       61 fincqskimg gnsilhsaad svtsavqkas qalnergerl graeektedl knsaqqfaet
      121 ahklamkhkc
//
LOCUS       XP_047287256             130 aa            linear   PRI 05-AUG-2025
DEFINITION  syntaxin-binding protein 6 isoform X3 [Homo sapiens].
ACCESSION   XP_047287256
VERSION     XP_047287256.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431300.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 27% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..130
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..130
                     /product="syntaxin-binding protein 6 isoform X3"
                     /calculated_mol_wt=14472
     Region          <1..51
                     /region_name="PH-like"
                     /note="Pleckstrin homology-like domain; cl17171"
                     /db_xref="CDD:473070"
     Region          69..130
                     /region_name="SNARE"
                     /note="SNARE motif; cl22856"
                     /db_xref="CDD:473982"
     Site            order(93,100,103)
                     /site_type="other"
                     /note="flanking leucine-zipper layers"
                     /db_xref="CDD:277192"
     Site            96
                     /site_type="active"
                     /note="zero layer [active]"
                     /db_xref="CDD:277192"
     CDS             1..130
                     /gene="STXBP6"
                     /gene_synonym="amisyn; HSPC156"
                     /coded_by="XM_047431300.1:435..827"
                     /db_xref="GeneID:29091"
                     /db_xref="HGNC:HGNC:19666"
                     /db_xref="MIM:607958"
ORIGIN      
        1 mleqlrqvng idpngdsaef dllfenafdq wvastasekc tffqilhhtc qryltdrkpe
       61 fincqskimg gnsilhsaad svtsavqkas qalnergerl graeektedl knsaqqfaet
      121 ahklamkhkc
//
LOCUS       XP_011534973             175 aa            linear   PRI 05-AUG-2025
DEFINITION  maleylacetoacetate isomerase isoform X1 [Homo sapiens].
ACCESSION   XP_011534973
VERSION     XP_011534973.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536671.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..175
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..175
                     /product="maleylacetoacetate isomerase isoform X1"
                     /calculated_mol_wt=19360
     Region          8..170
                     /region_name="maiA"
                     /note="maleylacetoacetate isomerase; TIGR01262"
                     /db_xref="CDD:273527"
     CDS             1..175
                     /gene="GSTZ1"
                     /gene_synonym="GSTZ1-1; MAAI; MAAID; MAI"
                     /coded_by="XM_011536671.3:67..594"
                     /db_xref="GeneID:2954"
                     /db_xref="HGNC:HGNC:4643"
                     /db_xref="MIM:603758"
ORIGIN      
        1 mtesgkpily syfrsscswr vrialalkgi dyetvpinli kdggqqfskd fqalnpmkqv
       61 ptlkidgiti hqsnlsvlkq vgeemqltwa qnaitcgfna leqilqstag iycvgdevtm
      121 adlclvpqva naerfkvdlt pyptissink rllvleafqv shpcrqpdtp telra
//
LOCUS       XP_024305319             161 aa            linear   PRI 05-AUG-2025
DEFINITION  maleylacetoacetate isomerase isoform X2 [Homo sapiens].
ACCESSION   XP_024305319
VERSION     XP_024305319.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449551.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..161
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..161
                     /product="maleylacetoacetate isomerase isoform X2"
                     /calculated_mol_wt=17765
     Region          <1..156
                     /region_name="maiA"
                     /note="maleylacetoacetate isomerase; TIGR01262"
                     /db_xref="CDD:273527"
     CDS             1..161
                     /gene="GSTZ1"
                     /gene_synonym="GSTZ1-1; MAAI; MAAID; MAI"
                     /coded_by="XM_024449551.2:634..1119"
                     /db_xref="GeneID:2954"
                     /db_xref="HGNC:HGNC:4643"
                     /db_xref="MIM:603758"
ORIGIN      
        1 mkqvptlkid gitihqslai ieyleemrpt prllpqdpkk rasvrmisdl iaggiqplqn
       61 lsvlkqvgee mqltwaqnai tcgfnaleqi lqstagiycv gdevtmadlc lvpqvanaer
      121 fkvdltpypt issinkrllv leafqvshpc rqpdtptelr a
//
LOCUS       XP_024305320             161 aa            linear   PRI 05-AUG-2025
DEFINITION  maleylacetoacetate isomerase isoform X2 [Homo sapiens].
ACCESSION   XP_024305320
VERSION     XP_024305320.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449552.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..161
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..161
                     /product="maleylacetoacetate isomerase isoform X2"
                     /calculated_mol_wt=17765
     Region          <1..156
                     /region_name="maiA"
                     /note="maleylacetoacetate isomerase; TIGR01262"
                     /db_xref="CDD:273527"
     CDS             1..161
                     /gene="GSTZ1"
                     /gene_synonym="GSTZ1-1; MAAI; MAAID; MAI"
                     /coded_by="XM_024449552.2:448..933"
                     /db_xref="GeneID:2954"
                     /db_xref="HGNC:HGNC:4643"
                     /db_xref="MIM:603758"
ORIGIN      
        1 mkqvptlkid gitihqslai ieyleemrpt prllpqdpkk rasvrmisdl iaggiqplqn
       61 lsvlkqvgee mqltwaqnai tcgfnaleqi lqstagiycv gdevtmadlc lvpqvanaer
      121 fkvdltpypt issinkrllv leafqvshpc rqpdtptelr a
//
LOCUS       XP_011534974             632 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor IIIB 90 kDa subunit isoform X2 [Homo sapiens].
ACCESSION   XP_011534974
VERSION     XP_011534974.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536672.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..632
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..632
                     /product="transcription factor IIIB 90 kDa subunit isoform
                     X2"
                     /calculated_mol_wt=69228
     Region          4..45
                     /region_name="TF_Zn_Ribbon"
                     /note="TFIIB zinc-binding; pfam08271"
                     /db_xref="CDD:400527"
     Region          84..174
                     /region_name="CYCLIN_TFIIIB90_rpt1"
                     /note="first cyclin box found in transcription factor IIIB
                     90 kDa subunit (TFIIIB90) and similar proteins; cd20553"
                     /db_xref="CDD:410256"
     Site            order(85,124..127,161,165,168..169)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410256"
     Region          179..270
                     /region_name="CYCLIN_TFIIIB90_rpt2"
                     /note="second cyclin box found in transcription factor
                     IIIB 90 kDa subunit (TFIIIB90) and similar proteins;
                     cd20554"
                     /db_xref="CDD:410257"
     Site            order(222..224,255..256,258..259)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410257"
     Region          450..546
                     /region_name="BRF1"
                     /note="Brf1-like TBP-binding domain; pfam07741"
                     /db_xref="CDD:462250"
     CDS             1..632
                     /gene="BRF1"
                     /gene_synonym="BRF; BRF-1; CFDS; GTF3B; hBRF; HEL-S-76p;
                     TAF3B2; TAF3C; TAFIII90; TF3B90; TFIIIB90"
                     /coded_by="XM_011536672.4:373..2271"
                     /db_xref="GeneID:2972"
                     /db_xref="HGNC:HGNC:11551"
                     /db_xref="MIM:604902"
ORIGIN      
        1 mtgrvcrgcg gtdieldaar gdavctacgs vledniivse vqfvessggg ssavgqfvsl
       61 dgagktptlg ggfhvnlgke sraqtlqngr rhihhlgnql qlnqhcldta fnffkmavsr
      121 hltrgrkmah viaaclylvc rtegtphmll dlsdllqvnv yvlgktflll arelcinapa
      181 idpclyiprf ahllefgekn hevsmtalrl lqrmkrdwmh tgrrpsglcg aallvaarmh
      241 dfrrtvkevi svvkvcestl rkrltefedt ptsqltidef mkidleeecd ppsytagqrk
      301 lrmkqleqvl skkleevege issyqdaiei elensrpkak gglaslakdg stedtasslc
      361 geedtedeel eaaashlnkd lyrellggap gsseaagspe wggrppalgs lldplptaas
      421 lgisdsirec issqssdpkd asgdgeldls giddleidry ilnesearvk aelwmrenae
      481 ylreqrekea riakekelgi ykehkpkksc krrepiqast areaiekmle qkkisskiny
      541 svlrglssag ggsphredaq pehsasarkl srrrtpasrs gadpvtsvgk rrgwdnpwgr
      601 cllqpgfgkk spqpcrpvpa lrtlaalpsl lr
//
LOCUS       XP_047287258             626 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor IIIB 90 kDa subunit isoform X4 [Homo sapiens].
ACCESSION   XP_047287258
VERSION     XP_047287258.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431302.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..626
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..626
                     /product="transcription factor IIIB 90 kDa subunit isoform
                     X4"
                     /calculated_mol_wt=67758
     Region          4..216
                     /region_name="SUA7"
                     /note="Transcription initiation factor TFIIIB, Brf1
                     subunit/Transcription initiation factor TFIIB
                     [Transcription]; COG1405"
                     /db_xref="CDD:441015"
     Region          84..174
                     /region_name="CYCLIN_TFIIIB90_rpt1"
                     /note="first cyclin box found in transcription factor IIIB
                     90 kDa subunit (TFIIIB90) and similar proteins; cd20553"
                     /db_xref="CDD:410256"
     Site            order(85,124..127,161,165,168..169)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410256"
     Region          399..495
                     /region_name="BRF1"
                     /note="Brf1-like TBP-binding domain; pfam07741"
                     /db_xref="CDD:462250"
     CDS             1..626
                     /gene="BRF1"
                     /gene_synonym="BRF; BRF-1; CFDS; GTF3B; hBRF; HEL-S-76p;
                     TAF3B2; TAF3C; TAFIII90; TF3B90; TFIIIB90"
                     /coded_by="XM_047431302.1:373..2253"
                     /db_xref="GeneID:2972"
                     /db_xref="HGNC:HGNC:11551"
                     /db_xref="MIM:604902"
ORIGIN      
        1 mtgrvcrgcg gtdieldaar gdavctacgs vledniivse vqfvessggg ssavgqfvsl
       61 dgagktptlg ggfhvnlgke sraqtlqngr rhihhlgnql qlnqhcldta fnffkmavsr
      121 hltrgrkmah viaaclylvc rtegtphmll dlsdllqvnv yvlgktflll arelcinapa
      181 iallvaarmh dfrrtvkevi svvkvcestl rkrltefedt ptsqltidef mkidleeecd
      241 ppsytagqrk lrmkqleqvl skkleevege issyqdaiei elensrpkak gglaslakdg
      301 stedtasslc geedtedeel eaaashlnkd lyrellggap gsseaagspe wggrppalgs
      361 lldplptaas lgisdsirec issqssdpna sgdgeldlsg iddleidryi lnesearvka
      421 elwmrenaey lreqrekear iakekelgiy kehkpkksck rrepiqasta reaiekmleq
      481 kkisskinys vlrglssagg gsphredaqp ehsasarkls rrrtpasrsg adpvtsvgkr
      541 lrplvstqpa kkvatgeall pssptlgaep arpqavlves gpvsyhadee adeeepdeed
      601 gepcvsalqm mgsndygcdg deddgy
//
LOCUS       XP_047287259             513 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor IIIB 90 kDa subunit isoform X5 [Homo sapiens].
ACCESSION   XP_047287259
VERSION     XP_047287259.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431303.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..513
                     /product="transcription factor IIIB 90 kDa subunit isoform
                     X5"
                     /calculated_mol_wt=56420
     Region          18..106
                     /region_name="CYCLIN_TFIIIB90_rpt2"
                     /note="second cyclin box found in transcription factor
                     IIIB 90 kDa subunit (TFIIIB90) and similar proteins;
                     cd20554"
                     /db_xref="CDD:410257"
     Site            order(58..60,91..92,94..95)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410257"
     Region          286..382
                     /region_name="BRF1"
                     /note="Brf1-like TBP-binding domain; pfam07741"
                     /db_xref="CDD:462250"
     CDS             1..513
                     /gene="BRF1"
                     /gene_synonym="BRF; BRF-1; CFDS; GTF3B; hBRF; HEL-S-76p;
                     TAF3B2; TAF3C; TAFIII90; TF3B90; TFIIIB90"
                     /coded_by="XM_047431303.1:45..1586"
                     /db_xref="GeneID:2972"
                     /db_xref="HGNC:HGNC:11551"
                     /db_xref="MIM:604902"
ORIGIN      
        1 msfeqwreil skhgtpqdpc lyiprfahll efgeknhevs mtalrllqrm krdwmhtgrr
       61 psglcgaall vaarmhdfrr tvkevisvvk vcestlrkrl tefedtptsq ltidefmkid
      121 leeecdppsy tagqrklrmk qleqvlskkl eevegeissy qdaieielen srpkakggla
      181 slakdgsted tasslcgeed tedeeleaaa shlnkdlyre llggapgsse aagspewggr
      241 ppalgslldp lptaaslgis dsirecissq ssdpkdasgd geldlsgidd leidryilne
      301 searvkaelw mrenaeylre qrekeariak ekelgiykeh kpkksckrre piqastarea
      361 iekmleqkki sskinysvlr glssagggsp hredaqpehs asarklsrrr tpasrsgadp
      421 vtsvgkrlrp lvstqpakkv atgeallpss ptlgaeparp qavlvesgpv syhadeeade
      481 eepdeedgep cvsalqmmgs ndygcdgded dgy
//
LOCUS       XP_047287261             511 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor IIIB 90 kDa subunit isoform X7 [Homo sapiens].
ACCESSION   XP_047287261
VERSION     XP_047287261.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431305.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..511
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..511
                     /product="transcription factor IIIB 90 kDa subunit isoform
                     X7"
                     /calculated_mol_wt=55730
     Region          <1..59
                     /region_name="CYCLIN_TFIIIB90_rpt1"
                     /note="first cyclin box found in transcription factor IIIB
                     90 kDa subunit (TFIIIB90) and similar proteins; cd20553"
                     /db_xref="CDD:410256"
     Site            order(9..12,46,50,53..54)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410256"
     Region          <67..105
                     /region_name="CYCLIN_SF"
                     /note="Cyclin box fold superfamily; cl40454"
                     /db_xref="CDD:477360"
     Region          284..380
                     /region_name="BRF1"
                     /note="Brf1-like TBP-binding domain; pfam07741"
                     /db_xref="CDD:462250"
     CDS             1..511
                     /gene="BRF1"
                     /gene_synonym="BRF; BRF-1; CFDS; GTF3B; hBRF; HEL-S-76p;
                     TAF3B2; TAF3C; TAFIII90; TF3B90; TFIIIB90"
                     /coded_by="XM_047431305.1:430..1965"
                     /db_xref="GeneID:2972"
                     /db_xref="HGNC:HGNC:11551"
                     /db_xref="MIM:604902"
ORIGIN      
        1 mavsrhltrg rkmahviaac lylvcrtegt phmlldlsdl lqvnvyvlgk tflllarelc
       61 inapaiallv aarmhdfrrt vkevisvvkv cestlrkrlt efedtptsql tidefmkidl
      121 eeecdppsyt agqrklrmkq leqvlskkle evegeissyq daieielens rpkakgglas
      181 lakdgstedt asslcgeedt edeeleaaas hlnkdlyrel lggapgssea agspewggrp
      241 palgslldpl ptaaslgisd sirecissqs sdpnasgdge ldlsgiddle idryilnese
      301 arvkaelwmr enaeylreqr ekeariakek elgiykehkp kksckrrepi qastareaie
      361 kmleqkkiss kinysvlrgl ssagggsphr edaqpehsas arklsrrrtp asrsgadpvt
      421 svgkrlrplv stqpakkvat geallpsspt lgaeparpqa vlvesgpvsy hadeeadeee
      481 pdeedgepcv salqmmgsnd ygcdgdeddg y
//
LOCUS       XP_005267620             473 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor IIIB 90 kDa subunit isoform X10 [Homo
            sapiens].
ACCESSION   XP_005267620
VERSION     XP_005267620.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267563.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..473
                     /product="transcription factor IIIB 90 kDa subunit isoform
                     X10"
                     /calculated_mol_wt=51667
     Region          <1..66
                     /region_name="CYCLIN_TFIIIB90_rpt2"
                     /note="second cyclin box found in transcription factor
                     IIIB 90 kDa subunit (TFIIIB90) and similar proteins;
                     cd20554"
                     /db_xref="CDD:410257"
     Site            order(18..20,51..52,54..55)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410257"
     Region          246..342
                     /region_name="BRF1"
                     /note="Brf1-like TBP-binding domain; pfam07741"
                     /db_xref="CDD:462250"
     CDS             1..473
                     /gene="BRF1"
                     /gene_synonym="BRF; BRF-1; CFDS; GTF3B; hBRF; HEL-S-76p;
                     TAF3B2; TAF3C; TAFIII90; TF3B90; TFIIIB90"
                     /coded_by="XM_005267563.5:263..1684"
                     /db_xref="GeneID:2972"
                     /db_xref="HGNC:HGNC:11551"
                     /db_xref="MIM:604902"
ORIGIN      
        1 mtalrllqrm krdwmhtgrr psglcgaall vaarmhdfrr tvkevisvvk vcestlrkrl
       61 tefedtptsq ltidefmkid leeecdppsy tagqrklrmk qleqvlskkl eevegeissy
      121 qdaieielen srpkakggla slakdgsted tasslcgeed tedeeleaaa shlnkdlyre
      181 llggapgsse aagspewggr ppalgslldp lptaaslgis dsirecissq ssdpkdasgd
      241 geldlsgidd leidryilne searvkaelw mrenaeylre qrekeariak ekelgiykeh
      301 kpkksckrre piqastarea iekmleqkki sskinysvlr glssagggsp hredaqpehs
      361 asarklsrrr tpasrsgadp vtsvgkrlrp lvstqpakkv atgeallpss ptlgaeparp
      421 qavlvesgpv syhadeeade eepdeedgep cvsalqmmgs ndygcdgded dgy
//
LOCUS       XP_047287264             456 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor IIIB 90 kDa subunit isoform X11 [Homo
            sapiens].
ACCESSION   XP_047287264
VERSION     XP_047287264.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431308.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..456
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..456
                     /product="transcription factor IIIB 90 kDa subunit isoform
                     X11"
                     /calculated_mol_wt=49644
     Region          <9..49
                     /region_name="CYCLIN_SF"
                     /note="Cyclin box fold superfamily; cl40454"
                     /db_xref="CDD:477360"
     Region          229..325
                     /region_name="BRF1"
                     /note="Brf1-like TBP-binding domain; pfam07741"
                     /db_xref="CDD:462250"
     CDS             1..456
                     /gene="BRF1"
                     /gene_synonym="BRF; BRF-1; CFDS; GTF3B; hBRF; HEL-S-76p;
                     TAF3B2; TAF3C; TAFIII90; TF3B90; TFIIIB90"
                     /coded_by="XM_047431308.1:1158..2528"
                     /db_xref="GeneID:2972"
                     /db_xref="HGNC:HGNC:11551"
                     /db_xref="MIM:604902"
ORIGIN      
        1 mqsswrspaa allvaarmhd frrtvkevis vvkvcestlr krltefedtp tsqltidefm
       61 kidleeecdp psytagqrkl rmkqleqvls kkleevegei ssyqdaieie lensrpkakg
      121 glaslakdgs tedtasslcg eedtedeele aaashlnkdl yrellggapg sseaagspew
      181 ggrppalgsl ldplptaasl gisdsireci ssqssdpkda sgdgeldlsg iddleidryi
      241 lnesearvka elwmrenaey lreqrekear iakekelgiy kehkpkksck rrepiqasta
      301 reaiekmleq kkisskinys vlrglssagg gsphredaqp ehsasarkls rrrtpasrsg
      361 adpvtsvgkr lrplvstqpa kkvatgeall pssptlgaep arpqavlves gpvsyhadee
      421 adeeepdeed gepcvsalqm mgsndygcdg deddgy
//
LOCUS       XP_024305321             439 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor IIIB 90 kDa subunit isoform X13 [Homo
            sapiens].
ACCESSION   XP_024305321
VERSION     XP_024305321.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449553.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..439
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..439
                     /product="transcription factor IIIB 90 kDa subunit isoform
                     X13"
                     /calculated_mol_wt=47847
     Region          <1..32
                     /region_name="CYCLIN_SF"
                     /note="Cyclin box fold superfamily; cl40454"
                     /db_xref="CDD:477360"
     Region          212..308
                     /region_name="BRF1"
                     /note="Brf1-like TBP-binding domain; pfam07741"
                     /db_xref="CDD:462250"
     CDS             1..439
                     /gene="BRF1"
                     /gene_synonym="BRF; BRF-1; CFDS; GTF3B; hBRF; HEL-S-76p;
                     TAF3B2; TAF3C; TAFIII90; TF3B90; TFIIIB90"
                     /coded_by="XM_024449553.2:845..2164"
                     /db_xref="GeneID:2972"
                     /db_xref="HGNC:HGNC:11551"
                     /db_xref="MIM:604902"
ORIGIN      
        1 mhdfrrtvke visvvkvces tlrkrltefe dtptsqltid efmkidleee cdppsytagq
       61 rklrmkqleq vlskkleeve geissyqdai eielensrpk akgglaslak dgstedtass
      121 lcgeedtede eleaaashln kdlyrellgg apgsseaags pewggrppal gslldplpta
      181 aslgisdsir ecissqssdp kdasgdgeld lsgiddleid ryilnesear vkaelwmren
      241 aeylreqrek eariakekel giykehkpkk sckrrepiqa stareaiekm leqkkisski
      301 nysvlrglss agggsphred aqpehsasar klsrrrtpas rsgadpvtsv gkrlrplvst
      361 qpakkvatge allpssptlg aeparpqavl vesgpvsyha deeadeeepd eedgepcvsa
      421 lqmmgsndyg cdgdeddgy
//
LOCUS       XP_047287267             397 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor IIIB 90 kDa subunit isoform X14 [Homo
            sapiens].
ACCESSION   XP_047287267
VERSION     XP_047287267.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431311.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..397
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..397
                     /product="transcription factor IIIB 90 kDa subunit isoform
                     X14"
                     /calculated_mol_wt=42879
     Region          170..266
                     /region_name="BRF1"
                     /note="Brf1-like TBP-binding domain; pfam07741"
                     /db_xref="CDD:462250"
     CDS             1..397
                     /gene="BRF1"
                     /gene_synonym="BRF; BRF-1; CFDS; GTF3B; hBRF; HEL-S-76p;
                     TAF3B2; TAF3C; TAFIII90; TF3B90; TFIIIB90"
                     /coded_by="XM_047431311.1:207..1400"
                     /db_xref="GeneID:2972"
                     /db_xref="HGNC:HGNC:11551"
                     /db_xref="MIM:604902"
ORIGIN      
        1 mkidleeecd ppsytagqrk lrmkqleqvl skkleevege issyqdaiei elensrpkak
       61 gglaslakdg stedtasslc geedtedeel eaaashlnkd lyrellggap gsseaagspe
      121 wggrppalgs lldplptaas lgisdsirec issqssdpkd asgdgeldls giddleidry
      181 ilnesearvk aelwmrenae ylreqrekea riakekelgi ykehkpkksc krrepiqast
      241 areaiekmle qkkisskiny svlrglssag ggsphredaq pehsasarkl srrrtpasrs
      301 gadpvtsvgk rlrplvstqp akkvatgeal lpssptlgae parpqavlve sgpvsyhade
      361 eadeeepdee dgepcvsalq mmgsndygcd gdeddgy
//
LOCUS       XP_047287268             826 aa            linear   PRI 05-AUG-2025
DEFINITION  protein O-mannosyl-transferase 2 isoform X1 [Homo sapiens].
ACCESSION   XP_047287268
VERSION     XP_047287268.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431312.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..826
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..826
                     /product="protein O-mannosyl-transferase 2 isoform X1"
                     /calculated_mol_wt=92822
     Region          62..306
                     /region_name="PMT"
                     /note="Dolichyl-phosphate-mannose-protein
                     mannosyltransferase; pfam02366"
                     /db_xref="CDD:396786"
     Region          337..536
                     /region_name="beta-trefoil_MIR_POMT2"
                     /note="MIR domain, beta-trefoil fold, found in protein
                     O-mannosyl-transferase 2 (POMT2) and similar proteins;
                     cd23282"
                     /db_xref="CDD:467753"
     Site            order(448,499,501,520,526)
                     /site_type="other"
                     /note="putative heterodimer interface [polypeptide
                     binding]"
                     /db_xref="CDD:467753"
     Region          555..822
                     /region_name="PMT_4TMC"
                     /note="C-terminal four TMM region of
                     protein-O-mannosyltransferase; pfam16192"
                     /db_xref="CDD:465056"
     CDS             1..826
                     /gene="POMT2"
                     /gene_synonym="LGMD2N; LGMDR14; MDDGA2; MDDGB2; MDDGC2"
                     /coded_by="XM_047431312.1:203..2683"
                     /db_xref="GeneID:29954"
                     /db_xref="HGNC:HGNC:19743"
                     /db_xref="MIM:607439"
ORIGIN      
        1 mppatgggla eselrprrgr cgpqaaraag rdvaaeavar spkrpawgsr rfeavgwwal
       61 lalvtllsfa trfhrldepp hicwdethfg kmgsyyinrt fffdvhpplg kmliglagyl
      121 sgydgtflfq kpgdkyehhs ymgmrgfcaf lgswlvpfay ltvldlsksl saalltaall
      181 tfdtgcltls qyilldpilm ffimaamlsm vkynscadrp fsapwwfwls ltgvslagal
      241 gvkfvglfii lqvglntiad lwylfgdlsl slvtvgkhlt arvlclivlp lalytatfav
      301 hfmvlsksgp gdgffssafq arlsgnnlhn asipehlayg svitvknlrm aigylhshrh
      361 lypegigarq qqvttylhkd ynnlwiikkh ntnsdpldps fpvefvrhgd iirlehkecp
      421 lkkiwrweqk etsrnlhshy heapmtrkhy qvtgygingt gdsndfwrie vvnrkfgnri
      481 kvlrsrirfi hlvtgcvlgs sgkvlpkwgw eqlevtctpy lketlnsiwn vedhinpklp
      541 nisldvlqps fpeilleshm vmirgnsglk pkdneftskp whwpinyqgl rfsgvndtdf
      601 rvyllgnpvv wwlnllsial yllsgsiiav amqrgarlpa evagqvlwal ppltwrqqgt
      661 ctpgegrlpa dgpsfafttp hlplsfafer kprnheikkl apghtarlsq vllrgggqvl
      721 lgwtlhyfpf flmgrvlyfh hyfpamlfss mltgilwdtl lrlcawglas wplargihva
      781 gilslllgta ysfylfhpla ygmvgplaqd pqspmaglrw ldswdf
//
LOCUS       XP_011534977             813 aa            linear   PRI 05-AUG-2025
DEFINITION  protein O-mannosyl-transferase 2 isoform X2 [Homo sapiens].
ACCESSION   XP_011534977
VERSION     XP_011534977.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536675.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..813
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..813
                     /product="protein O-mannosyl-transferase 2 isoform X2"
                     /calculated_mol_wt=91096
     Region          62..306
                     /region_name="PMT"
                     /note="Dolichyl-phosphate-mannose-protein
                     mannosyltransferase; pfam02366"
                     /db_xref="CDD:396786"
     Region          337..523
                     /region_name="beta-trefoil_MIR_POMT2"
                     /note="MIR domain, beta-trefoil fold, found in protein
                     O-mannosyl-transferase 2 (POMT2) and similar proteins;
                     cd23282"
                     /db_xref="CDD:467753"
     Site            order(435,486,488,507,513)
                     /site_type="other"
                     /note="putative heterodimer interface [polypeptide
                     binding]"
                     /db_xref="CDD:467753"
     Region          542..809
                     /region_name="PMT_4TMC"
                     /note="C-terminal four TMM region of
                     protein-O-mannosyltransferase; pfam16192"
                     /db_xref="CDD:465056"
     CDS             1..813
                     /gene="POMT2"
                     /gene_synonym="LGMD2N; LGMDR14; MDDGA2; MDDGB2; MDDGC2"
                     /coded_by="XM_011536675.3:203..2644"
                     /db_xref="GeneID:29954"
                     /db_xref="HGNC:HGNC:19743"
                     /db_xref="MIM:607439"
ORIGIN      
        1 mppatgggla eselrprrgr cgpqaaraag rdvaaeavar spkrpawgsr rfeavgwwal
       61 lalvtllsfa trfhrldepp hicwdethfg kmgsyyinrt fffdvhpplg kmliglagyl
      121 sgydgtflfq kpgdkyehhs ymgmrgfcaf lgswlvpfay ltvldlsksl saalltaall
      181 tfdtgcltls qyilldpilm ffimaamlsm vkynscadrp fsapwwfwls ltgvslagal
      241 gvkfvglfii lqvglntiad lwylfgdlsl slvtvgkhlt arvlclivlp lalytatfav
      301 hfmvlsksgp gdgffssafq arlsgnnlhn asipehlayg svitvknlrm aigylhshrh
      361 lypegigarq qqvttylhkd ynnlwiikkh ntnsdpldps fpvefvrhgd iirlehkets
      421 rnlhshyhea pmtrkhyqvt gygingtgds ndfwrievvn rkfgnrikvl rsrirfihlv
      481 tgcvlgssgk vlpkwgweql evtctpylke tlnsiwnved hinpklpnis ldvlqpsfpe
      541 illeshmvmi rgnsglkpkd neftskpwhw pinyqglrfs gvndtdfrvy llgnpvvwwl
      601 nllsialyll sgsiiavamq rgarlpaeva gqvlwalppl twrqqgtctp gegrlpadgp
      661 sfafttphlp lsfaferkpr nheikklapg htarlsqvll rgggqvllgw tlhyfpfflm
      721 grvlyfhhyf pamlfssmlt gilwdtllrl cawglaswpl argihvagil slllgtaysf
      781 ylfhplaygm vgplaqdpqs pmaglrwlds wdf
//
LOCUS       XP_047287269             763 aa            linear   PRI 05-AUG-2025
DEFINITION  protein O-mannosyl-transferase 2 isoform X3 [Homo sapiens].
ACCESSION   XP_047287269
VERSION     XP_047287269.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431313.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..763
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..763
                     /product="protein O-mannosyl-transferase 2 isoform X3"
                     /calculated_mol_wt=85809
     Region          62..306
                     /region_name="PMT"
                     /note="Dolichyl-phosphate-mannose-protein
                     mannosyltransferase; pfam02366"
                     /db_xref="CDD:396786"
     Region          337..536
                     /region_name="beta-trefoil_MIR_POMT2"
                     /note="MIR domain, beta-trefoil fold, found in protein
                     O-mannosyl-transferase 2 (POMT2) and similar proteins;
                     cd23282"
                     /db_xref="CDD:467753"
     Site            order(448,499,501,520,526)
                     /site_type="other"
                     /note="putative heterodimer interface [polypeptide
                     binding]"
                     /db_xref="CDD:467753"
     Region          555..759
                     /region_name="PMT_4TMC"
                     /note="C-terminal four TMM region of
                     protein-O-mannosyltransferase; pfam16192"
                     /db_xref="CDD:465056"
     CDS             1..763
                     /gene="POMT2"
                     /gene_synonym="LGMD2N; LGMDR14; MDDGA2; MDDGB2; MDDGC2"
                     /coded_by="XM_047431313.1:203..2494"
                     /db_xref="GeneID:29954"
                     /db_xref="HGNC:HGNC:19743"
                     /db_xref="MIM:607439"
ORIGIN      
        1 mppatgggla eselrprrgr cgpqaaraag rdvaaeavar spkrpawgsr rfeavgwwal
       61 lalvtllsfa trfhrldepp hicwdethfg kmgsyyinrt fffdvhpplg kmliglagyl
      121 sgydgtflfq kpgdkyehhs ymgmrgfcaf lgswlvpfay ltvldlsksl saalltaall
      181 tfdtgcltls qyilldpilm ffimaamlsm vkynscadrp fsapwwfwls ltgvslagal
      241 gvkfvglfii lqvglntiad lwylfgdlsl slvtvgkhlt arvlclivlp lalytatfav
      301 hfmvlsksgp gdgffssafq arlsgnnlhn asipehlayg svitvknlrm aigylhshrh
      361 lypegigarq qqvttylhkd ynnlwiikkh ntnsdpldps fpvefvrhgd iirlehkecp
      421 lkkiwrweqk etsrnlhshy heapmtrkhy qvtgygingt gdsndfwrie vvnrkfgnri
      481 kvlrsrirfi hlvtgcvlgs sgkvlpkwgw eqlevtctpy lketlnsiwn vedhinpklp
      541 nisldvlqps fpeilleshm vmirgnsglk pkdneftskp whwpinyqgl rfsgvndtdf
      601 rvyllgnpvv wwlnllsial yllsgsiiav amqrgarlpa evaglsqvll rgggqvllgw
      661 tlhyfpfflm grvlyfhhyf pamlfssmlt gilwdtllrl cawglaswpl argihvagil
      721 slllgtaysf ylfhplaygm vgplaqdpqs pmaglrwlds wdf
//
LOCUS       XP_047287270             715 aa            linear   PRI 05-AUG-2025
DEFINITION  protein O-mannosyl-transferase 2 isoform X4 [Homo sapiens].
ACCESSION   XP_047287270
VERSION     XP_047287270.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431314.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 16% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..715
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..715
                     /product="protein O-mannosyl-transferase 2 isoform X4"
                     /calculated_mol_wt=80465
     Region          <1..195
                     /region_name="PMT"
                     /note="Dolichyl-phosphate-mannose-protein
                     mannosyltransferase; pfam02366"
                     /db_xref="CDD:396786"
     Region          226..425
                     /region_name="beta-trefoil_MIR_POMT2"
                     /note="MIR domain, beta-trefoil fold, found in protein
                     O-mannosyl-transferase 2 (POMT2) and similar proteins;
                     cd23282"
                     /db_xref="CDD:467753"
     Site            order(337,388,390,409,415)
                     /site_type="other"
                     /note="putative heterodimer interface [polypeptide
                     binding]"
                     /db_xref="CDD:467753"
     Region          444..711
                     /region_name="PMT_4TMC"
                     /note="C-terminal four TMM region of
                     protein-O-mannosyltransferase; pfam16192"
                     /db_xref="CDD:465056"
     CDS             1..715
                     /gene="POMT2"
                     /gene_synonym="LGMD2N; LGMDR14; MDDGA2; MDDGB2; MDDGC2"
                     /coded_by="XM_047431314.1:451..2598"
                     /db_xref="GeneID:29954"
                     /db_xref="HGNC:HGNC:19743"
                     /db_xref="MIM:607439"
ORIGIN      
        1 mliglagyls gydgtflfqk pgdkyehhsy mgmrgfcafl gswlvpfayl tvldlsksls
       61 aalltaallt fdtgcltlsq yilldpilmf fimaamlsmv kynscadrpf sapwwfwlsl
      121 tgvslagalg vkfvglfiil qvglntiadl wylfgdlsls lvtvgkhlta rvlclivlpl
      181 alytatfavh fmvlsksgpg dgffssafqa rlsgnnlhna sipehlaygs vitvknlrma
      241 igylhshrhl ypegigarqq qvttylhkdy nnlwiikkhn tnsdpldpsf pvefvrhgdi
      301 irlehkecpl kkiwrweqke tsrnlhshyh eapmtrkhyq vtgygingtg dsndfwriev
      361 vnrkfgnrik vlrsrirfih lvtgcvlgss gkvlpkwgwe qlevtctpyl ketlnsiwnv
      421 edhinpklpn isldvlqpsf peilleshmv mirgnsglkp kdneftskpw hwpinyqglr
      481 fsgvndtdfr vyllgnpvvw wlnllsialy llsgsiiava mqrgarlpae vagqvlwalp
      541 pltwrqqgtc tpgegrlpad gpsfafttph lplsfaferk prnheikkla pghtarlsqv
      601 llrgggqvll gwtlhyfpff lmgrvlyfhh yfpamlfssm ltgilwdtll rlcawglasw
      661 plargihvag ilslllgtay sfylfhplay gmvgplaqdp qspmaglrwl dswdf
//
LOCUS       XP_047287271             685 aa            linear   PRI 05-AUG-2025
DEFINITION  protein O-mannosyl-transferase 2 isoform X5 [Homo sapiens].
ACCESSION   XP_047287271
VERSION     XP_047287271.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431315.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..685
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..685
                     /product="protein O-mannosyl-transferase 2 isoform X5"
                     /calculated_mol_wt=76871
     Region          62..306
                     /region_name="PMT"
                     /note="Dolichyl-phosphate-mannose-protein
                     mannosyltransferase; pfam02366"
                     /db_xref="CDD:396786"
     Region          337..536
                     /region_name="beta-trefoil_MIR_POMT2"
                     /note="MIR domain, beta-trefoil fold, found in protein
                     O-mannosyl-transferase 2 (POMT2) and similar proteins;
                     cd23282"
                     /db_xref="CDD:467753"
     Site            order(448,499,501,520,526)
                     /site_type="other"
                     /note="putative heterodimer interface [polypeptide
                     binding]"
                     /db_xref="CDD:467753"
     Region          555..>635
                     /region_name="PMT_4TMC"
                     /note="C-terminal four TMM region of
                     protein-O-mannosyltransferase; pfam16192"
                     /db_xref="CDD:465056"
     CDS             1..685
                     /gene="POMT2"
                     /gene_synonym="LGMD2N; LGMDR14; MDDGA2; MDDGB2; MDDGC2"
                     /coded_by="XM_047431315.1:203..2260"
                     /db_xref="GeneID:29954"
                     /db_xref="HGNC:HGNC:19743"
                     /db_xref="MIM:607439"
ORIGIN      
        1 mppatgggla eselrprrgr cgpqaaraag rdvaaeavar spkrpawgsr rfeavgwwal
       61 lalvtllsfa trfhrldepp hicwdethfg kmgsyyinrt fffdvhpplg kmliglagyl
      121 sgydgtflfq kpgdkyehhs ymgmrgfcaf lgswlvpfay ltvldlsksl saalltaall
      181 tfdtgcltls qyilldpilm ffimaamlsm vkynscadrp fsapwwfwls ltgvslagal
      241 gvkfvglfii lqvglntiad lwylfgdlsl slvtvgkhlt arvlclivlp lalytatfav
      301 hfmvlsksgp gdgffssafq arlsgnnlhn asipehlayg svitvknlrm aigylhshrh
      361 lypegigarq qqvttylhkd ynnlwiikkh ntnsdpldps fpvefvrhgd iirlehkecp
      421 lkkiwrweqk etsrnlhshy heapmtrkhy qvtgygingt gdsndfwrie vvnrkfgnri
      481 kvlrsrirfi hlvtgcvlgs sgkvlpkwgw eqlevtctpy lketlnsiwn vedhinpklp
      541 nisldvlqps fpeilleshm vmirgnsglk pkdneftskp whwpinyqgl rfsgvndtdf
      601 rvyllgnpvv wwlnllsial yllsgsiiav amqrgarlpa evagnqgtmr lrnlpqdiql
      661 gcprscfeea arscsaghsi tsrfs
//
LOCUS       XP_047287272             673 aa            linear   PRI 05-AUG-2025
DEFINITION  protein O-mannosyl-transferase 2 isoform X6 [Homo sapiens].
ACCESSION   XP_047287272
VERSION     XP_047287272.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431316.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..673
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..673
                     /product="protein O-mannosyl-transferase 2 isoform X6"
                     /calculated_mol_wt=76163
     Region          62..>168
                     /region_name="PMT_2"
                     /note="Dolichyl-phosphate-mannose-protein
                     mannosyltransferase; cl21590"
                     /db_xref="CDD:473917"
     Region          184..383
                     /region_name="beta-trefoil_MIR_POMT2"
                     /note="MIR domain, beta-trefoil fold, found in protein
                     O-mannosyl-transferase 2 (POMT2) and similar proteins;
                     cd23282"
                     /db_xref="CDD:467753"
     Site            order(295,346,348,367,373)
                     /site_type="other"
                     /note="putative heterodimer interface [polypeptide
                     binding]"
                     /db_xref="CDD:467753"
     Region          402..669
                     /region_name="PMT_4TMC"
                     /note="C-terminal four TMM region of
                     protein-O-mannosyltransferase; pfam16192"
                     /db_xref="CDD:465056"
     CDS             1..673
                     /gene="POMT2"
                     /gene_synonym="LGMD2N; LGMDR14; MDDGA2; MDDGB2; MDDGC2"
                     /coded_by="XM_047431316.1:203..2224"
                     /db_xref="GeneID:29954"
                     /db_xref="HGNC:HGNC:19743"
                     /db_xref="MIM:607439"
ORIGIN      
        1 mppatgggla eselrprrgr cgpqaaraag rdvaaeavar spkrpawgsr rfeavgwwal
       61 lalvtllsfa trfhrldepp hicwdethfg kmgsyyinrt fffdvhpplg kmliglagyl
      121 sgydgtflfq kpgdkyehhs ymgmrgfcaf lgswlvpfay ltvldlsksl saalltaall
      181 tfdlaygsvi tvknlrmaig ylhshrhlyp egigarqqqv ttylhkdynn lwiikkhntn
      241 sdpldpsfpv efvrhgdiir lehkecplkk iwrweqkets rnlhshyhea pmtrkhyqvt
      301 gygingtgds ndfwrievvn rkfgnrikvl rsrirfihlv tgcvlgssgk vlpkwgweql
      361 evtctpylke tlnsiwnved hinpklpnis ldvlqpsfpe illeshmvmi rgnsglkpkd
      421 neftskpwhw pinyqglrfs gvndtdfrvy llgnpvvwwl nllsialyll sgsiiavamq
      481 rgarlpaeva gqvlwalppl twrqqgtctp gegrlpadgp sfafttphlp lsfaferkpr
      541 nheikklapg htarlsqvll rgggqvllgw tlhyfpfflm grvlyfhhyf pamlfssmlt
      601 gilwdtllrl cawglaswpl argihvagil slllgtaysf ylfhplaygm vgplaqdpqs
      661 pmaglrwlds wdf
//
LOCUS       XP_011534979             660 aa            linear   PRI 05-AUG-2025
DEFINITION  protein O-mannosyl-transferase 2 isoform X7 [Homo sapiens].
ACCESSION   XP_011534979
VERSION     XP_011534979.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536677.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..660
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..660
                     /product="protein O-mannosyl-transferase 2 isoform X7"
                     /calculated_mol_wt=74436
     Region          62..>168
                     /region_name="PMT_2"
                     /note="Dolichyl-phosphate-mannose-protein
                     mannosyltransferase; cl21590"
                     /db_xref="CDD:473917"
     Region          184..370
                     /region_name="beta-trefoil_MIR_POMT2"
                     /note="MIR domain, beta-trefoil fold, found in protein
                     O-mannosyl-transferase 2 (POMT2) and similar proteins;
                     cd23282"
                     /db_xref="CDD:467753"
     Site            order(282,333,335,354,360)
                     /site_type="other"
                     /note="putative heterodimer interface [polypeptide
                     binding]"
                     /db_xref="CDD:467753"
     Region          389..656
                     /region_name="PMT_4TMC"
                     /note="C-terminal four TMM region of
                     protein-O-mannosyltransferase; pfam16192"
                     /db_xref="CDD:465056"
     CDS             1..660
                     /gene="POMT2"
                     /gene_synonym="LGMD2N; LGMDR14; MDDGA2; MDDGB2; MDDGC2"
                     /coded_by="XM_011536677.4:203..2185"
                     /db_xref="GeneID:29954"
                     /db_xref="HGNC:HGNC:19743"
                     /db_xref="MIM:607439"
ORIGIN      
        1 mppatgggla eselrprrgr cgpqaaraag rdvaaeavar spkrpawgsr rfeavgwwal
       61 lalvtllsfa trfhrldepp hicwdethfg kmgsyyinrt fffdvhpplg kmliglagyl
      121 sgydgtflfq kpgdkyehhs ymgmrgfcaf lgswlvpfay ltvldlsksl saalltaall
      181 tfdlaygsvi tvknlrmaig ylhshrhlyp egigarqqqv ttylhkdynn lwiikkhntn
      241 sdpldpsfpv efvrhgdiir lehketsrnl hshyheapmt rkhyqvtgyg ingtgdsndf
      301 wrievvnrkf gnrikvlrsr irfihlvtgc vlgssgkvlp kwgweqlevt ctpylketln
      361 siwnvedhin pklpnisldv lqpsfpeill eshmvmirgn sglkpkdnef tskpwhwpin
      421 yqglrfsgvn dtdfrvyllg npvvwwlnll sialyllsgs iiavamqrga rlpaevagqv
      481 lwalppltwr qqgtctpgeg rlpadgpsfa fttphlplsf aferkprnhe ikklapghta
      541 rlsqvllrgg gqvllgwtlh yfpfflmgrv lyfhhyfpam lfssmltgil wdtllrlcaw
      601 glaswplarg ihvagilsll lgtaysfylf hplaygmvgp laqdpqspma glrwldswdf
//
LOCUS       XP_047287273             627 aa            linear   PRI 05-AUG-2025
DEFINITION  protein O-mannosyl-transferase 2 isoform X8 [Homo sapiens].
ACCESSION   XP_047287273
VERSION     XP_047287273.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431317.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..627
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..627
                     /product="protein O-mannosyl-transferase 2 isoform X8"
                     /calculated_mol_wt=70835
     Region          <1..107
                     /region_name="PMT_2"
                     /note="Dolichyl-phosphate-mannose-protein
                     mannosyltransferase; cl21590"
                     /db_xref="CDD:473917"
     Region          138..337
                     /region_name="beta-trefoil_MIR_POMT2"
                     /note="MIR domain, beta-trefoil fold, found in protein
                     O-mannosyl-transferase 2 (POMT2) and similar proteins;
                     cd23282"
                     /db_xref="CDD:467753"
     Site            order(249,300,302,321,327)
                     /site_type="other"
                     /note="putative heterodimer interface [polypeptide
                     binding]"
                     /db_xref="CDD:467753"
     Region          356..623
                     /region_name="PMT_4TMC"
                     /note="C-terminal four TMM region of
                     protein-O-mannosyltransferase; pfam16192"
                     /db_xref="CDD:465056"
     CDS             1..627
                     /gene="POMT2"
                     /gene_synonym="LGMD2N; LGMDR14; MDDGA2; MDDGB2; MDDGC2"
                     /coded_by="XM_047431317.1:270..2153"
                     /db_xref="GeneID:29954"
                     /db_xref="HGNC:HGNC:19743"
                     /db_xref="MIM:607439"
ORIGIN      
        1 mffimaamls mvkynscadr pfsapwwfwl sltgvslaga lgvkfvglfi ilqvglntia
       61 dlwylfgdls lslvtvgkhl tarvlclivl plalytatfa vhfmvlsksg pgdgffssaf
      121 qarlsgnnlh nasipehlay gsvitvknlr maigylhshr hlypegigar qqqvttylhk
      181 dynnlwiikk hntnsdpldp sfpvefvrhg diirlehkec plkkiwrweq ketsrnlhsh
      241 yheapmtrkh yqvtgyging tgdsndfwri evvnrkfgnr ikvlrsrirf ihlvtgcvlg
      301 ssgkvlpkwg weqlevtctp ylketlnsiw nvedhinpkl pnisldvlqp sfpeillesh
      361 mvmirgnsgl kpkdneftsk pwhwpinyqg lrfsgvndtd frvyllgnpv vwwlnllsia
      421 lyllsgsiia vamqrgarlp aevagqvlwa lppltwrqqg tctpgegrlp adgpsfaftt
      481 phlplsfafe rkprnheikk lapghtarls qvllrgggqv llgwtlhyfp fflmgrvlyf
      541 hhyfpamlfs smltgilwdt llrlcawgla swplargihv agilslllgt aysfylfhpl
      601 aygmvgplaq dpqspmaglr wldswdf
//
LOCUS       XP_047287274             597 aa            linear   PRI 05-AUG-2025
DEFINITION  protein O-mannosyl-transferase 2 isoform X9 [Homo sapiens].
ACCESSION   XP_047287274
VERSION     XP_047287274.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431318.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..597
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..597
                     /product="protein O-mannosyl-transferase 2 isoform X9"
                     /calculated_mol_wt=67423
     Region          62..>168
                     /region_name="PMT_2"
                     /note="Dolichyl-phosphate-mannose-protein
                     mannosyltransferase; cl21590"
                     /db_xref="CDD:473917"
     Region          184..370
                     /region_name="beta-trefoil_MIR_POMT2"
                     /note="MIR domain, beta-trefoil fold, found in protein
                     O-mannosyl-transferase 2 (POMT2) and similar proteins;
                     cd23282"
                     /db_xref="CDD:467753"
     Site            order(282,333,335,354,360)
                     /site_type="other"
                     /note="putative heterodimer interface [polypeptide
                     binding]"
                     /db_xref="CDD:467753"
     Region          389..593
                     /region_name="PMT_4TMC"
                     /note="C-terminal four TMM region of
                     protein-O-mannosyltransferase; pfam16192"
                     /db_xref="CDD:465056"
     CDS             1..597
                     /gene="POMT2"
                     /gene_synonym="LGMD2N; LGMDR14; MDDGA2; MDDGB2; MDDGC2"
                     /coded_by="XM_047431318.1:203..1996"
                     /db_xref="GeneID:29954"
                     /db_xref="HGNC:HGNC:19743"
                     /db_xref="MIM:607439"
ORIGIN      
        1 mppatgggla eselrprrgr cgpqaaraag rdvaaeavar spkrpawgsr rfeavgwwal
       61 lalvtllsfa trfhrldepp hicwdethfg kmgsyyinrt fffdvhpplg kmliglagyl
      121 sgydgtflfq kpgdkyehhs ymgmrgfcaf lgswlvpfay ltvldlsksl saalltaall
      181 tfdlaygsvi tvknlrmaig ylhshrhlyp egigarqqqv ttylhkdynn lwiikkhntn
      241 sdpldpsfpv efvrhgdiir lehketsrnl hshyheapmt rkhyqvtgyg ingtgdsndf
      301 wrievvnrkf gnrikvlrsr irfihlvtgc vlgssgkvlp kwgweqlevt ctpylketln
      361 siwnvedhin pklpnisldv lqpsfpeill eshmvmirgn sglkpkdnef tskpwhwpin
      421 yqglrfsgvn dtdfrvyllg npvvwwlnll sialyllsgs iiavamqrga rlpaevagls
      481 qvllrgggqv llgwtlhyfp fflmgrvlyf hhyfpamlfs smltgilwdt llrlcawgla
      541 swplargihv agilslllgt aysfylfhpl aygmvgplaq dpqspmaglr wldswdf
//
LOCUS       XP_047287275             511 aa            linear   PRI 05-AUG-2025
DEFINITION  protein O-mannosyl-transferase 2 isoform X10 [Homo sapiens].
ACCESSION   XP_047287275
VERSION     XP_047287275.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431319.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..511
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..511
                     /product="protein O-mannosyl-transferase 2 isoform X10"
                     /calculated_mol_wt=57750
     Region          35..221
                     /region_name="beta-trefoil_MIR_POMT2"
                     /note="MIR domain, beta-trefoil fold, found in protein
                     O-mannosyl-transferase 2 (POMT2) and similar proteins;
                     cd23282"
                     /db_xref="CDD:467753"
     Site            order(133,184,186,205,211)
                     /site_type="other"
                     /note="putative heterodimer interface [polypeptide
                     binding]"
                     /db_xref="CDD:467753"
     Region          240..507
                     /region_name="PMT_4TMC"
                     /note="C-terminal four TMM region of
                     protein-O-mannosyltransferase; pfam16192"
                     /db_xref="CDD:465056"
     CDS             1..511
                     /gene="POMT2"
                     /gene_synonym="LGMD2N; LGMDR14; MDDGA2; MDDGB2; MDDGC2"
                     /coded_by="XM_047431319.1:310..1845"
                     /db_xref="GeneID:29954"
                     /db_xref="HGNC:HGNC:19743"
                     /db_xref="MIM:607439"
ORIGIN      
        1 mvlsksgpgd gffssafqar lsgnnlhnas ipehlaygsv itvknlrmai gylhshrhly
       61 pegigarqqq vttylhkdyn nlwiikkhnt nsdpldpsfp vefvrhgdii rlehketsrn
      121 lhshyheapm trkhyqvtgy gingtgdsnd fwrievvnrk fgnrikvlrs rirfihlvtg
      181 cvlgssgkvl pkwgweqlev tctpylketl nsiwnvedhi npklpnisld vlqpsfpeil
      241 leshmvmirg nsglkpkdne ftskpwhwpi nyqglrfsgv ndtdfrvyll gnpvvwwlnl
      301 lsialyllsg siiavamqrg arlpaevagq vlwalppltw rqqgtctpge grlpadgpsf
      361 afttphlpls faferkprnh eikklapght arlsqvllrg ggqvllgwtl hyfpfflmgr
      421 vlyfhhyfpa mlfssmltgi lwdtllrlca wglaswplar gihvagilsl llgtaysfyl
      481 fhplaygmvg plaqdpqspm aglrwldswd f
//
LOCUS       XP_047287276             448 aa            linear   PRI 05-AUG-2025
DEFINITION  protein O-mannosyl-transferase 2 isoform X11 [Homo sapiens].
ACCESSION   XP_047287276
VERSION     XP_047287276.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431320.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..448
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..448
                     /product="protein O-mannosyl-transferase 2 isoform X11"
                     /calculated_mol_wt=50737
     Region          35..221
                     /region_name="beta-trefoil_MIR_POMT2"
                     /note="MIR domain, beta-trefoil fold, found in protein
                     O-mannosyl-transferase 2 (POMT2) and similar proteins;
                     cd23282"
                     /db_xref="CDD:467753"
     Site            order(133,184,186,205,211)
                     /site_type="other"
                     /note="putative heterodimer interface [polypeptide
                     binding]"
                     /db_xref="CDD:467753"
     Region          240..444
                     /region_name="PMT_4TMC"
                     /note="C-terminal four TMM region of
                     protein-O-mannosyltransferase; pfam16192"
                     /db_xref="CDD:465056"
     CDS             1..448
                     /gene="POMT2"
                     /gene_synonym="LGMD2N; LGMDR14; MDDGA2; MDDGB2; MDDGC2"
                     /coded_by="XM_047431320.1:310..1656"
                     /db_xref="GeneID:29954"
                     /db_xref="HGNC:HGNC:19743"
                     /db_xref="MIM:607439"
ORIGIN      
        1 mvlsksgpgd gffssafqar lsgnnlhnas ipehlaygsv itvknlrmai gylhshrhly
       61 pegigarqqq vttylhkdyn nlwiikkhnt nsdpldpsfp vefvrhgdii rlehketsrn
      121 lhshyheapm trkhyqvtgy gingtgdsnd fwrievvnrk fgnrikvlrs rirfihlvtg
      181 cvlgssgkvl pkwgweqlev tctpylketl nsiwnvedhi npklpnisld vlqpsfpeil
      241 leshmvmirg nsglkpkdne ftskpwhwpi nyqglrfsgv ndtdfrvyll gnpvvwwlnl
      301 lsialyllsg siiavamqrg arlpaevagl sqvllrgggq vllgwtlhyf pfflmgrvly
      361 fhhyfpamlf ssmltgilwd tllrlcawgl aswplargih vagilslllg taysfylfhp
      421 laygmvgpla qdpqspmagl rwldswdf
//
LOCUS       XP_047287277             821 aa            linear   PRI 05-AUG-2025
DEFINITION  striatin-3 isoform X1 [Homo sapiens].
ACCESSION   XP_047287277
VERSION     XP_047287277.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431321.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..821
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..821
                     /product="striatin-3 isoform X1"
                     /calculated_mol_wt=90701
     Region          <110..214
                     /region_name="Striatin"
                     /note="Striatin family; pfam08232"
                     /db_xref="CDD:462401"
     Region          499..820
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cd00200"
                     /db_xref="CDD:238121"
     Site            order(503,521,525,531..532,555..556,574,578,584..585,
                     608..609,626,631,637..638,655,673,677,683..684,696..697,
                     722,726,732..733,745..746,763,768,774..775,787..788,810,
                     814,820)
                     /site_type="active"
                     /note="structural tetrad [active]"
                     /db_xref="CDD:238121"
     Region          509..555
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          561..608
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          613..650
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          659..695
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          708..744
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          750..789
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          796..820
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..821
                     /gene="STRN3"
                     /gene_synonym="PPP2R6B; S/G2NA; SG2NA"
                     /coded_by="XM_047431321.1:1478..3943"
                     /db_xref="GeneID:29966"
                     /db_xref="HGNC:HGNC:15720"
                     /db_xref="MIM:614766"
ORIGIN      
        1 mtslsftwss smyfwlihml vvvvfvlfcf flfiqglals lrlecsgnhg slqprplrsn
       61 dppasapqva gitgvhrhtq liikflvktr cccvgqaglk llvlsdllpw tlevlglqar
      121 iaflqgerkg qenlkkdlvr rikmleyalk qerakyhklk ygtelnqgdl kmptfeseet
      181 kdteaptapq nsqltwkqgr qllrqylqev gytdtildvr sqrvrsllgl snsepngsve
      241 tknleqilng gespkqkgqe ikrssgdvle tfnflenadd sdedeendmi egipegkdkh
      301 rmnkhkigne glaadltddp dteealkefd flvtaedgeg agearssgdg tewdkddlsp
      361 taevwdvdqg lisklkeqyk kerkgkkgvk ranrtklydm iadlgddelp hipsgiinqs
      421 rsastrmtdh egaraeeaep itfpsgggks fimgsddvll svlglgdlad ltvtndadys
      481 ydlpankdaf rktwnpkytl rshfdgvral afhpvepvlv tasedhtlkl wnlqktvpak
      541 ksasldvepi ytfrahigpv lslaissnge qcfsggidat iqwwnmpsps vdpydtyepn
      601 vlagtlvght davwglaysg iknqllscsa dgtvrlwnpq eklpcictyn gdkkhgipts
      661 vdfigcdpah mvtsfntgsa viydletsqs lvilssqvds glqsnnhinr vvshptlpvt
      721 itahedrhik ffdnktgkmi hsmvahldav tslavdpngi ylmsgshdcs irlwnldskt
      781 cvqeitahrk kldesiydva fhsskayias agadalakvf v
//
LOCUS       XP_005267626             760 aa            linear   PRI 05-AUG-2025
DEFINITION  striatin-3 isoform X2 [Homo sapiens].
ACCESSION   XP_005267626
VERSION     XP_005267626.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267569.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..760
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..760
                     /product="striatin-3 isoform X2"
                     /calculated_mol_wt=82737
     Region          65..190
                     /region_name="Striatin"
                     /note="Striatin family; pfam08232"
                     /db_xref="CDD:462401"
     Region          438..759
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cd00200"
                     /db_xref="CDD:238121"
     Site            order(442,460,464,470..471,494..495,513,517,523..524,
                     547..548,565,570,576..577,594,612,616,622..623,635..636,
                     661,665,671..672,684..685,702,707,713..714,726..727,749,
                     753,759)
                     /site_type="active"
                     /note="structural tetrad [active]"
                     /db_xref="CDD:238121"
     Region          448..494
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          500..547
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          552..589
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          598..634
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          647..683
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          689..728
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          735..759
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..760
                     /gene="STRN3"
                     /gene_synonym="PPP2R6B; S/G2NA; SG2NA"
                     /coded_by="XM_005267569.5:195..2477"
                     /db_xref="GeneID:29966"
                     /db_xref="HGNC:HGNC:15720"
                     /db_xref="MIM:614766"
ORIGIN      
        1 mdelaggggg gpgmaapprq qqgpggnlgl spggngaagg ggppasegag paagpelsrp
       61 qqytipgilh yiqhewarfe merahwever aelqariafl qgerkgqenl kkdlvrrikm
      121 leyalkqera kyhklkygte lnqgdlkmpt feseetkdte aptapqnsql twkqgrqllr
      181 qylqevgytd tildvrsqrv rsllglsnse pngsvetknl eqilnggesp kqkgqeikrs
      241 sgdvletfnf lenaddsded eendmiegip egkdkhrmnk hkigneglaa dltddpdtee
      301 alkefdflvt aedgegagea rssgdgtewg anrtklydmi adlgddelph ipsgiinqsr
      361 sastrmtdhe garaeeaepi tfpsgggksf imgsddvlls vlglgdladl tvtndadysy
      421 dlpankdafr ktwnpkytlr shfdgvrala fhpvepvlvt asedhtlklw nlqktvpakk
      481 sasldvepiy tfrahigpvl slaissngeq cfsggidati qwwnmpspsv dpydtyepnv
      541 lagtlvghtd avwglaysgi knqllscsad gtvrlwnpqe klpcictyng dkkhgiptsv
      601 dfigcdpahm vtsfntgsav iydletsqsl vilssqvdsg lqsnnhinrv vshptlpvti
      661 tahedrhikf fdnktgkmih smvahldavt slavdpngiy lmsgshdcsi rlwnldsktc
      721 vqeitahrkk ldesiydvaf hsskayiasa gadalakvfv
//
LOCUS       XP_005267627             750 aa            linear   PRI 05-AUG-2025
DEFINITION  striatin-3 isoform X3 [Homo sapiens].
ACCESSION   XP_005267627
VERSION     XP_005267627.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267570.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..750
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..750
                     /product="striatin-3 isoform X3"
                     /calculated_mol_wt=81887
     Region          65..190
                     /region_name="Striatin"
                     /note="Striatin family; pfam08232"
                     /db_xref="CDD:462401"
     Region          428..749
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cd00200"
                     /db_xref="CDD:238121"
     Site            order(432,450,454,460..461,484..485,503,507,513..514,
                     537..538,555,560,566..567,584,602,606,612..613,625..626,
                     651,655,661..662,674..675,692,697,703..704,716..717,739,
                     743,749)
                     /site_type="active"
                     /note="structural tetrad [active]"
                     /db_xref="CDD:238121"
     Region          438..484
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          490..537
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          542..579
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          588..624
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          637..673
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          679..718
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          725..749
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..750
                     /gene="STRN3"
                     /gene_synonym="PPP2R6B; S/G2NA; SG2NA"
                     /coded_by="XM_005267570.5:195..2447"
                     /db_xref="GeneID:29966"
                     /db_xref="HGNC:HGNC:15720"
                     /db_xref="MIM:614766"
ORIGIN      
        1 mdelaggggg gpgmaapprq qqgpggnlgl spggngaagg ggppasegag paagpelsrp
       61 qqytipgilh yiqhewarfe merahwever aelqariafl qgerkgqenl kkdlvrrikm
      121 leyalkqera kyhklkygte lnqgdlkmpt feseetkdte aptapqnsql twkqgrqllr
      181 qylqevgytd tildvrsqrv rsllglsnse pngsvetknl eqilnggesp kqkgqeikrs
      241 sgdvletfnf lenaddsded eendmiegip egkdkhrmnk hkigneglaa dltddpdtee
      301 alkefdflvt aedgegagea rssgdgtewd kddlsptaev wdvdqglisk lkeqykkerk
      361 gkkgvktepi tfpsgggksf imgsddvlls vlglgdladl tvtndadysy dlpankdafr
      421 ktwnpkytlr shfdgvrala fhpvepvlvt asedhtlklw nlqktvpakk sasldvepiy
      481 tfrahigpvl slaissngeq cfsggidati qwwnmpspsv dpydtyepnv lagtlvghtd
      541 avwglaysgi knqllscsad gtvrlwnpqe klpcictyng dkkhgiptsv dfigcdpahm
      601 vtsfntgsav iydletsqsl vilssqvdsg lqsnnhinrv vshptlpvti tahedrhikf
      661 fdnktgkmih smvahldavt slavdpngiy lmsgshdcsi rlwnldsktc vqeitahrkk
      721 ldesiydvaf hsskayiasa gadalakvfv
//
LOCUS       XP_011534992             623 aa            linear   PRI 05-AUG-2025
DEFINITION  protein SIX6OS1 isoform X1 [Homo sapiens].
ACCESSION   XP_011534992
VERSION     XP_011534992.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536690.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..623
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..623
                     /product="protein SIX6OS1 isoform X1"
                     /calculated_mol_wt=71890
     Region          73..623
                     /region_name="S6OS1"
                     /note="Six6 opposite strand transcript 1 family;
                     pfam15676"
                     /db_xref="CDD:464795"
     CDS             1..623
                     /gene="C14orf39"
                     /gene_synonym="POF18; Six6os1; SPGF52"
                     /coded_by="XM_011536690.4:128..1999"
                     /db_xref="GeneID:317761"
                     /db_xref="HGNC:HGNC:19849"
                     /db_xref="MIM:617307"
ORIGIN      
        1 mndslfvsld rlllefvfqy eqdistkeem iqrintsgsr irpgpgslhf sirshpsqas
       61 fplhslalfl leccediken kvticrihet inatdeeidh yckhseeikd ncrnwkptcd
      121 vfrkhedymq dqftvyqgtv ekdkemyhdy icqykevlkq yqlkysetpf sreyyekkre
      181 heeiqsrvla cteqlkmnet ifmkfrvpap fpsltkwtln ivnlrcetqd ilkhasnltk
      241 ssselkkevd emeieinyln qqisrhnetk alsetleekn kntenrkelk erifgkdehv
      301 ltlnktqssq lflpyesqkl vrpikmhsse prvadikees sakqsklani dfrqkendtq
      361 ifndsavdnh skcshittit ssqkfmqvrl ltpqkqsnsn qwsekgdkda eygdkgtvrq
      421 vreskctsqa iytehfgksv endsdeveer aenfprtsei piflgtpkav kapeslekik
      481 fpktppfein rnrnavpevq tekespglsf lmsytsrspg lnlfdssvfd teissdqfne
      541 hysarnlnpl sseqeignll ekpegedgft fsfpsdtsth tfgagkddfs fpfsfgqgqn
      601 sipssslkgf ssssqnttqf tff
//
LOCUS       XP_047287278             623 aa            linear   PRI 05-AUG-2025
DEFINITION  protein SIX6OS1 isoform X1 [Homo sapiens].
ACCESSION   XP_047287278
VERSION     XP_047287278.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431322.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..623
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..623
                     /product="protein SIX6OS1 isoform X1"
                     /calculated_mol_wt=71890
     Region          73..623
                     /region_name="S6OS1"
                     /note="Six6 opposite strand transcript 1 family;
                     pfam15676"
                     /db_xref="CDD:464795"
     CDS             1..623
                     /gene="C14orf39"
                     /gene_synonym="POF18; Six6os1; SPGF52"
                     /coded_by="XM_047431322.1:986..2857"
                     /db_xref="GeneID:317761"
                     /db_xref="HGNC:HGNC:19849"
                     /db_xref="MIM:617307"
ORIGIN      
        1 mndslfvsld rlllefvfqy eqdistkeem iqrintsgsr irpgpgslhf sirshpsqas
       61 fplhslalfl leccediken kvticrihet inatdeeidh yckhseeikd ncrnwkptcd
      121 vfrkhedymq dqftvyqgtv ekdkemyhdy icqykevlkq yqlkysetpf sreyyekkre
      181 heeiqsrvla cteqlkmnet ifmkfrvpap fpsltkwtln ivnlrcetqd ilkhasnltk
      241 ssselkkevd emeieinyln qqisrhnetk alsetleekn kntenrkelk erifgkdehv
      301 ltlnktqssq lflpyesqkl vrpikmhsse prvadikees sakqsklani dfrqkendtq
      361 ifndsavdnh skcshittit ssqkfmqvrl ltpqkqsnsn qwsekgdkda eygdkgtvrq
      421 vreskctsqa iytehfgksv endsdeveer aenfprtsei piflgtpkav kapeslekik
      481 fpktppfein rnrnavpevq tekespglsf lmsytsrspg lnlfdssvfd teissdqfne
      541 hysarnlnpl sseqeignll ekpegedgft fsfpsdtsth tfgagkddfs fpfsfgqgqn
      601 sipssslkgf ssssqnttqf tff
//
LOCUS       XP_016876736             622 aa            linear   PRI 05-AUG-2025
DEFINITION  protein SIX6OS1 isoform X2 [Homo sapiens].
ACCESSION   XP_016876736
VERSION     XP_016876736.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021247.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..622
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..622
                     /product="protein SIX6OS1 isoform X2"
                     /calculated_mol_wt=71762
     Region          73..622
                     /region_name="S6OS1"
                     /note="Six6 opposite strand transcript 1 family;
                     pfam15676"
                     /db_xref="CDD:464795"
     CDS             1..622
                     /gene="C14orf39"
                     /gene_synonym="POF18; Six6os1; SPGF52"
                     /coded_by="XM_017021247.2:128..1996"
                     /db_xref="GeneID:317761"
                     /db_xref="HGNC:HGNC:19849"
                     /db_xref="MIM:617307"
ORIGIN      
        1 mndslfvsld rlllefvfqy eqdistkeem iqrintsgsr irpgpgslhf sirshpsqas
       61 fplhslalfl leccediken kvticrihet inatdeeidh yckhseeikd ncrnwkptcd
      121 vfrkhedymq dqftvyqgtv ekdkemyhdy icqykevlkq yqlkysetpf sreyyekkre
      181 heeiqsrvla cteqlkmnet ifmkfrvpap fpsltkwtln ivnlrcetqd ilkhasnltk
      241 ssselkkevd emeieinyln qisrhnetka lsetleeknk ntenrkelke rifgkdehvl
      301 tlnktqssql flpyesqklv rpikmhssep rvadikeess akqsklanid frqkendtqi
      361 fndsavdnhs kcshittits sqkfmqvrll tpqkqsnsnq wsekgdkdae ygdkgtvrqv
      421 reskctsqai ytehfgksve ndsdeveera enfprtseip iflgtpkavk apeslekikf
      481 pktppfeinr nrnavpevqt ekespglsfl msytsrspgl nlfdssvfdt eissdqfneh
      541 ysarnlnpls seqeignlle kpegedgftf sfpsdtstht fgagkddfsf pfsfgqgqns
      601 ipssslkgfs sssqnttqft ff
//
LOCUS       XP_047287279             587 aa            linear   PRI 05-AUG-2025
DEFINITION  protein SIX6OS1 isoform X3 [Homo sapiens].
ACCESSION   XP_047287279
VERSION     XP_047287279.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431323.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..587
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..587
                     /product="protein SIX6OS1 isoform X3"
                     /calculated_mol_wt=68035
     Region          31..587
                     /region_name="S6OS1"
                     /note="Six6 opposite strand transcript 1 family;
                     pfam15676"
                     /db_xref="CDD:464795"
     CDS             1..587
                     /gene="C14orf39"
                     /gene_synonym="POF18; Six6os1; SPGF52"
                     /coded_by="XM_047431323.1:986..2749"
                     /db_xref="GeneID:317761"
                     /db_xref="HGNC:HGNC:19849"
                     /db_xref="MIM:617307"
ORIGIN      
        1 mndslfvsld rlllefvfqy eqdistkeem iqrinkcced ikenkvticr ihetinatde
       61 eidhyckhse eikdncrnwk ptcdvfrkhe dymqdqftvy qgtvekdkem yhdyicqyke
      121 vlkqyqlkys etpfsreyye kkreheeiqs rvlacteqlk mnetifmkfr vpapfpsltk
      181 wtlnivnlrc etqdilkhas nltkssselk kevdemeiei nylnqqisrh netkalsetl
      241 eeknkntenr kelkerifgk dehvltlnkt qssqlflpye sqklvrpikm hsseprvadi
      301 keessakqsk lanidfrqke ndtqifndsa vdnhskcshi ttitssqkfm qvrlltpqkq
      361 snsnqwsekg dkdaeygdkg tvrqvreskc tsqaiytehf gksvendsde veeraenfpr
      421 tseipiflgt pkavkapesl ekikfpktpp feinrnrnav pevqtekesp glsflmsyts
      481 rspglnlfds svfdteissd qfnehysarn lnplsseqei gnllekpege dgftfsfpsd
      541 tsthtfgagk ddfsfpfsfg qgqnsipsss lkgfssssqn ttqftff
//
LOCUS       XP_047287280             587 aa            linear   PRI 05-AUG-2025
DEFINITION  protein SIX6OS1 isoform X3 [Homo sapiens].
ACCESSION   XP_047287280
VERSION     XP_047287280.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431324.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..587
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..587
                     /product="protein SIX6OS1 isoform X3"
                     /calculated_mol_wt=68035
     Region          31..587
                     /region_name="S6OS1"
                     /note="Six6 opposite strand transcript 1 family;
                     pfam15676"
                     /db_xref="CDD:464795"
     CDS             1..587
                     /gene="C14orf39"
                     /gene_synonym="POF18; Six6os1; SPGF52"
                     /coded_by="XM_047431324.1:294..2057"
                     /db_xref="GeneID:317761"
                     /db_xref="HGNC:HGNC:19849"
                     /db_xref="MIM:617307"
ORIGIN      
        1 mndslfvsld rlllefvfqy eqdistkeem iqrinkcced ikenkvticr ihetinatde
       61 eidhyckhse eikdncrnwk ptcdvfrkhe dymqdqftvy qgtvekdkem yhdyicqyke
      121 vlkqyqlkys etpfsreyye kkreheeiqs rvlacteqlk mnetifmkfr vpapfpsltk
      181 wtlnivnlrc etqdilkhas nltkssselk kevdemeiei nylnqqisrh netkalsetl
      241 eeknkntenr kelkerifgk dehvltlnkt qssqlflpye sqklvrpikm hsseprvadi
      301 keessakqsk lanidfrqke ndtqifndsa vdnhskcshi ttitssqkfm qvrlltpqkq
      361 snsnqwsekg dkdaeygdkg tvrqvreskc tsqaiytehf gksvendsde veeraenfpr
      421 tseipiflgt pkavkapesl ekikfpktpp feinrnrnav pevqtekesp glsflmsyts
      481 rspglnlfds svfdteissd qfnehysarn lnplsseqei gnllekpege dgftfsfpsd
      541 tsthtfgagk ddfsfpfsfg qgqnsipsss lkgfssssqn ttqftff
//
LOCUS       XP_024305323             586 aa            linear   PRI 05-AUG-2025
DEFINITION  protein SIX6OS1 isoform X4 [Homo sapiens].
ACCESSION   XP_024305323
VERSION     XP_024305323.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449555.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..586
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..586
                     /product="protein SIX6OS1 isoform X4"
                     /calculated_mol_wt=67907
     Region          31..586
                     /region_name="S6OS1"
                     /note="Six6 opposite strand transcript 1 family;
                     pfam15676"
                     /db_xref="CDD:464795"
     CDS             1..586
                     /gene="C14orf39"
                     /gene_synonym="POF18; Six6os1; SPGF52"
                     /coded_by="XM_024449555.2:128..1888"
                     /db_xref="GeneID:317761"
                     /db_xref="HGNC:HGNC:19849"
                     /db_xref="MIM:617307"
ORIGIN      
        1 mndslfvsld rlllefvfqy eqdistkeem iqrinkcced ikenkvticr ihetinatde
       61 eidhyckhse eikdncrnwk ptcdvfrkhe dymqdqftvy qgtvekdkem yhdyicqyke
      121 vlkqyqlkys etpfsreyye kkreheeiqs rvlacteqlk mnetifmkfr vpapfpsltk
      181 wtlnivnlrc etqdilkhas nltkssselk kevdemeiei nylnqisrhn etkalsetle
      241 eknkntenrk elkerifgkd ehvltlnktq ssqlflpyes qklvrpikmh sseprvadik
      301 eessakqskl anidfrqken dtqifndsav dnhskcshit titssqkfmq vrlltpqkqs
      361 nsnqwsekgd kdaeygdkgt vrqvreskct sqaiytehfg ksvendsdev eeraenfprt
      421 seipiflgtp kavkapesle kikfpktppf einrnrnavp evqtekespg lsflmsytsr
      481 spglnlfdss vfdteissdq fnehysarnl nplsseqeig nllekpeged gftfsfpsdt
      541 sthtfgagkd dfsfpfsfgq gqnsipsssl kgfssssqnt tqftff
//
LOCUS       XP_016876737             558 aa            linear   PRI 05-AUG-2025
DEFINITION  protein SIX6OS1 isoform X5 [Homo sapiens].
ACCESSION   XP_016876737
VERSION     XP_016876737.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021248.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..558
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..558
                     /product="protein SIX6OS1 isoform X5"
                     /calculated_mol_wt=64543
     Region          2..558
                     /region_name="S6OS1"
                     /note="Six6 opposite strand transcript 1 family;
                     pfam15676"
                     /db_xref="CDD:464795"
     CDS             1..558
                     /gene="C14orf39"
                     /gene_synonym="POF18; Six6os1; SPGF52"
                     /coded_by="XM_017021248.3:158..1834"
                     /db_xref="GeneID:317761"
                     /db_xref="HGNC:HGNC:19849"
                     /db_xref="MIM:617307"
ORIGIN      
        1 miqrinkcce dikenkvtic rihetinatd eeidhyckhs eeikdncrnw kptcdvfrkh
       61 edymqdqftv yqgtvekdke myhdyicqyk evlkqyqlky setpfsreyy ekkreheeiq
      121 srvlacteql kmnetifmkf rvpapfpslt kwtlnivnlr cetqdilkha snltksssel
      181 kkevdemeie inylnqqisr hnetkalset leeknknten rkelkerifg kdehvltlnk
      241 tqssqlflpy esqklvrpik mhsseprvad ikeessakqs klanidfrqk endtqifnds
      301 avdnhskcsh ittitssqkf mqvrlltpqk qsnsnqwsek gdkdaeygdk gtvrqvresk
      361 ctsqaiyteh fgksvendsd eveeraenfp rtseipiflg tpkavkapes lekikfpktp
      421 pfeinrnrna vpevqtekes pglsflmsyt srspglnlfd ssvfdteiss dqfnehysar
      481 nlnplsseqe ignllekpeg edgftfsfps dtsthtfgag kddfsfpfsf gqgqnsipss
      541 slkgfssssq nttqftff
//
LOCUS       XP_047287281             557 aa            linear   PRI 05-AUG-2025
DEFINITION  protein SIX6OS1 isoform X6 [Homo sapiens].
ACCESSION   XP_047287281
VERSION     XP_047287281.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431325.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..557
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..557
                     /product="protein SIX6OS1 isoform X6"
                     /calculated_mol_wt=64344
     Region          31..557
                     /region_name="S6OS1"
                     /note="Six6 opposite strand transcript 1 family;
                     pfam15676"
                     /db_xref="CDD:464795"
     CDS             1..557
                     /gene="C14orf39"
                     /gene_synonym="POF18; Six6os1; SPGF52"
                     /coded_by="XM_047431325.1:128..1801"
                     /db_xref="GeneID:317761"
                     /db_xref="HGNC:HGNC:19849"
                     /db_xref="MIM:617307"
ORIGIN      
        1 mndslfvsld rlllefvfqy eqdistkeem iqrinkcced ikenkvticr ihetinatde
       61 eidhyckhse eikdncrkem yhdyicqyke vlkqyqlkys etpfsreyye kkreheeiqs
      121 rvlacteqlk mnetifmkfr vpapfpsltk wtlnivnlrc etqdilkhas nltkssselk
      181 kevdemeiei nylnqqisrh netkalsetl eeknkntenr kelkerifgk dehvltlnkt
      241 qssqlflpye sqklvrpikm hsseprvadi keessakqsk lanidfrqke ndtqifndsa
      301 vdnhskcshi ttitssqkfm qvrlltpqkq snsnqwsekg dkdaeygdkg tvrqvreskc
      361 tsqaiytehf gksvendsde veeraenfpr tseipiflgt pkavkapesl ekikfpktpp
      421 feinrnrnav pevqtekesp glsflmsyts rspglnlfds svfdteissd qfnehysarn
      481 lnplsseqei gnllekpege dgftfsfpsd tsthtfgagk ddfsfpfsfg qgqnsipsss
      541 lkgfssssqn ttqftff
//
LOCUS       XP_047287282             557 aa            linear   PRI 05-AUG-2025
DEFINITION  protein SIX6OS1 isoform X6 [Homo sapiens].
ACCESSION   XP_047287282
VERSION     XP_047287282.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431326.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..557
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..557
                     /product="protein SIX6OS1 isoform X6"
                     /calculated_mol_wt=64344
     Region          31..557
                     /region_name="S6OS1"
                     /note="Six6 opposite strand transcript 1 family;
                     pfam15676"
                     /db_xref="CDD:464795"
     CDS             1..557
                     /gene="C14orf39"
                     /gene_synonym="POF18; Six6os1; SPGF52"
                     /coded_by="XM_047431326.1:986..2659"
                     /db_xref="GeneID:317761"
                     /db_xref="HGNC:HGNC:19849"
                     /db_xref="MIM:617307"
ORIGIN      
        1 mndslfvsld rlllefvfqy eqdistkeem iqrinkcced ikenkvticr ihetinatde
       61 eidhyckhse eikdncrkem yhdyicqyke vlkqyqlkys etpfsreyye kkreheeiqs
      121 rvlacteqlk mnetifmkfr vpapfpsltk wtlnivnlrc etqdilkhas nltkssselk
      181 kevdemeiei nylnqqisrh netkalsetl eeknkntenr kelkerifgk dehvltlnkt
      241 qssqlflpye sqklvrpikm hsseprvadi keessakqsk lanidfrqke ndtqifndsa
      301 vdnhskcshi ttitssqkfm qvrlltpqkq snsnqwsekg dkdaeygdkg tvrqvreskc
      361 tsqaiytehf gksvendsde veeraenfpr tseipiflgt pkavkapesl ekikfpktpp
      421 feinrnrnav pevqtekesp glsflmsyts rspglnlfds svfdteissd qfnehysarn
      481 lnplsseqei gnllekpege dgftfsfpsd tsthtfgagk ddfsfpfsfg qgqnsipsss
      541 lkgfssssqn ttqftff
//
LOCUS       XP_047287283             556 aa            linear   PRI 05-AUG-2025
DEFINITION  protein SIX6OS1 isoform X7 [Homo sapiens].
ACCESSION   XP_047287283
VERSION     XP_047287283.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431327.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..556
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..556
                     /product="protein SIX6OS1 isoform X7"
                     /calculated_mol_wt=64216
     Region          31..556
                     /region_name="S6OS1"
                     /note="Six6 opposite strand transcript 1 family;
                     pfam15676"
                     /db_xref="CDD:464795"
     CDS             1..556
                     /gene="C14orf39"
                     /gene_synonym="POF18; Six6os1; SPGF52"
                     /coded_by="XM_047431327.1:128..1798"
                     /db_xref="GeneID:317761"
                     /db_xref="HGNC:HGNC:19849"
                     /db_xref="MIM:617307"
ORIGIN      
        1 mndslfvsld rlllefvfqy eqdistkeem iqrinkcced ikenkvticr ihetinatde
       61 eidhyckhse eikdncrkem yhdyicqyke vlkqyqlkys etpfsreyye kkreheeiqs
      121 rvlacteqlk mnetifmkfr vpapfpsltk wtlnivnlrc etqdilkhas nltkssselk
      181 kevdemeiei nylnqisrhn etkalsetle eknkntenrk elkerifgkd ehvltlnktq
      241 ssqlflpyes qklvrpikmh sseprvadik eessakqskl anidfrqken dtqifndsav
      301 dnhskcshit titssqkfmq vrlltpqkqs nsnqwsekgd kdaeygdkgt vrqvreskct
      361 sqaiytehfg ksvendsdev eeraenfprt seipiflgtp kavkapesle kikfpktppf
      421 einrnrnavp evqtekespg lsflmsytsr spglnlfdss vfdteissdq fnehysarnl
      481 nplsseqeig nllekpeged gftfsfpsdt sthtfgagkd dfsfpfsfgq gqnsipsssl
      541 kgfssssqnt tqftff
//
LOCUS       XP_016876739             478 aa            linear   PRI 05-AUG-2025
DEFINITION  protein SIX6OS1 isoform X8 [Homo sapiens].
ACCESSION   XP_016876739
VERSION     XP_016876739.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021250.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..478
                     /product="protein SIX6OS1 isoform X8"
                     /calculated_mol_wt=54849
     Region          1..478
                     /region_name="S6OS1"
                     /note="Six6 opposite strand transcript 1 family;
                     pfam15676"
                     /db_xref="CDD:464795"
     CDS             1..478
                     /gene="C14orf39"
                     /gene_synonym="POF18; Six6os1; SPGF52"
                     /coded_by="XM_017021250.3:9445..10881"
                     /db_xref="GeneID:317761"
                     /db_xref="HGNC:HGNC:19849"
                     /db_xref="MIM:617307"
ORIGIN      
        1 myhdyicqyk evlkqyqlky setpfsreyy ekkreheeiq srvlacteql kmnetifmkf
       61 rvpapfpslt kwtlnivnlr cetqdilkha snltksssel kkevdemeie inylnqqisr
      121 hnetkalset leeknknten rkelkerifg kdehvltlnk tqssqlflpy esqklvrpik
      181 mhsseprvad ikeessakqs klanidfrqk endtqifnds avdnhskcsh ittitssqkf
      241 mqvrlltpqk qsnsnqwsek gdkdaeygdk gtvrqvresk ctsqaiyteh fgksvendsd
      301 eveeraenfp rtseipiflg tpkavkapes lekikfpktp pfeinrnrna vpevqtekes
      361 pglsflmsyt srspglnlfd ssvfdteiss dqfnehysar nlnplsseqe ignllekpeg
      421 edgftfsfps dtsthtfgag kddfsfpfsf gqgqnsipss slkgfssssq nttqftff
//
LOCUS       XP_016876740             478 aa            linear   PRI 05-AUG-2025
DEFINITION  protein SIX6OS1 isoform X8 [Homo sapiens].
ACCESSION   XP_016876740
VERSION     XP_016876740.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021251.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..478
                     /product="protein SIX6OS1 isoform X8"
                     /calculated_mol_wt=54849
     Region          1..478
                     /region_name="S6OS1"
                     /note="Six6 opposite strand transcript 1 family;
                     pfam15676"
                     /db_xref="CDD:464795"
     CDS             1..478
                     /gene="C14orf39"
                     /gene_synonym="POF18; Six6os1; SPGF52"
                     /coded_by="XM_017021251.2:84..1520"
                     /db_xref="GeneID:317761"
                     /db_xref="HGNC:HGNC:19849"
                     /db_xref="MIM:617307"
ORIGIN      
        1 myhdyicqyk evlkqyqlky setpfsreyy ekkreheeiq srvlacteql kmnetifmkf
       61 rvpapfpslt kwtlnivnlr cetqdilkha snltksssel kkevdemeie inylnqqisr
      121 hnetkalset leeknknten rkelkerifg kdehvltlnk tqssqlflpy esqklvrpik
      181 mhsseprvad ikeessakqs klanidfrqk endtqifnds avdnhskcsh ittitssqkf
      241 mqvrlltpqk qsnsnqwsek gdkdaeygdk gtvrqvresk ctsqaiyteh fgksvendsd
      301 eveeraenfp rtseipiflg tpkavkapes lekikfpktp pfeinrnrna vpevqtekes
      361 pglsflmsyt srspglnlfd ssvfdteiss dqfnehysar nlnplsseqe ignllekpeg
      421 edgftfsfps dtsthtfgag kddfsfpfsf gqgqnsipss slkgfssssq nttqftff
//
LOCUS       XP_011535005             429 aa            linear   PRI 05-AUG-2025
DEFINITION  protein SIX6OS1 isoform X9 [Homo sapiens].
ACCESSION   XP_011535005
VERSION     XP_011535005.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536703.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..429
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..429
                     /product="protein SIX6OS1 isoform X9"
                     /calculated_mol_wt=50340
     Region          73..>429
                     /region_name="S6OS1"
                     /note="Six6 opposite strand transcript 1 family;
                     pfam15676"
                     /db_xref="CDD:464795"
     CDS             1..429
                     /gene="C14orf39"
                     /gene_synonym="POF18; Six6os1; SPGF52"
                     /coded_by="XM_011536703.3:128..1417"
                     /db_xref="GeneID:317761"
                     /db_xref="HGNC:HGNC:19849"
                     /db_xref="MIM:617307"
ORIGIN      
        1 mndslfvsld rlllefvfqy eqdistkeem iqrintsgsr irpgpgslhf sirshpsqas
       61 fplhslalfl leccediken kvticrihet inatdeeidh yckhseeikd ncrnwkptcd
      121 vfrkhedymq dqftvyqgtv ekdkemyhdy icqykevlkq yqlkysetpf sreyyekkre
      181 heeiqsrvla cteqlkmnet ifmkfrvpap fpsltkwtln ivnlrcetqd ilkhasnltk
      241 ssselkkevd emeieinyln qqisrhnetk alsetleekn kntenrkelk erifgkdehv
      301 ltlnktqssq lflpyesqkl vrpikmhsse prvadikees sakqsklani dfrqkendtq
      361 ifndsavdnh skcshittit ssqkfmqvrl ltpqkqsnsn qwsekgdkda eygdkgtvrq
      421 vreskctsq
//
LOCUS       XP_011535008             346 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 85C isoform X1 [Homo
            sapiens].
ACCESSION   XP_011535008
VERSION     XP_011535008.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536706.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..346
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..346
                     /product="coiled-coil domain-containing protein 85C
                     isoform X1"
                     /calculated_mol_wt=36868
     Region          12..202
                     /region_name="CCDC85"
                     /note="CCDC85 family; pfam10226"
                     /db_xref="CDD:463009"
     CDS             1..346
                     /gene="CCDC85C"
                     /coded_by="XM_011536706.3:249..1289"
                     /db_xref="GeneID:317762"
                     /db_xref="HGNC:HGNC:35459"
                     /db_xref="MIM:621283"
ORIGIN      
        1 makpaataaa aseelsqvpd eellrwskee larrlrraeg ekvglmlehg glmrdvnrrl
       61 qqhlleirgl kdvnqrlqdd nqelrelccf ldddrqkgrk larewqrfgr haagavwhev
      121 arsqqklrel earqeallre nlelkelvll ldeeraalaa tgaasggggg gggagsrssi
      181 dsqaslsgpl sggapgagar dvgdgsstss agsggspdhh hhvpppllpp gphkapdgka
      241 gatrrslddl sapphhrsip nglhdpssty irqleskvrl legdkllaql prpygrprsw
      301 lqvpialrvd vgpslqtaps sssaavklas cdrspgaptg qkqegt
//
LOCUS       XP_047287284             333 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 85C isoform X2 [Homo
            sapiens].
ACCESSION   XP_047287284
VERSION     XP_047287284.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431328.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..333
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..333
                     /product="coiled-coil domain-containing protein 85C
                     isoform X2"
                     /calculated_mol_wt=35261
     Region          12..202
                     /region_name="CCDC85"
                     /note="CCDC85 family; pfam10226"
                     /db_xref="CDD:463009"
     CDS             1..333
                     /gene="CCDC85C"
                     /coded_by="XM_047431328.1:249..1250"
                     /db_xref="GeneID:317762"
                     /db_xref="HGNC:HGNC:35459"
                     /db_xref="MIM:621283"
ORIGIN      
        1 makpaataaa aseelsqvpd eellrwskee larrlrraeg ekvglmlehg glmrdvnrrl
       61 qqhlleirgl kdvnqrlqdd nqelrelccf ldddrqkgrk larewqrfgr haagavwhev
      121 arsqqklrel earqeallre nlelkelvll ldeeraalaa tgaasggggg gggagsrssi
      181 dsqaslsgpl sggapgagar dvgdgsstss agsggspdhh hhvpppllpp gphkapdgka
      241 gatrrslddl sapphhrsip nglhdpssty irqleskvrl legdkllaqv pialrvdvgp
      301 slqtapssss aavklascdr spgaptgqkq egt
//
LOCUS       XP_011535009             307 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 85C isoform X3 [Homo
            sapiens].
ACCESSION   XP_011535009
VERSION     XP_011535009.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536707.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..307
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..307
                     /product="coiled-coil domain-containing protein 85C
                     isoform X3"
                     /calculated_mol_wt=33021
     Region          12..202
                     /region_name="CCDC85"
                     /note="CCDC85 family; pfam10226"
                     /db_xref="CDD:463009"
     CDS             1..307
                     /gene="CCDC85C"
                     /coded_by="XM_011536707.3:249..1172"
                     /db_xref="GeneID:317762"
                     /db_xref="HGNC:HGNC:35459"
                     /db_xref="MIM:621283"
ORIGIN      
        1 makpaataaa aseelsqvpd eellrwskee larrlrraeg ekvglmlehg glmrdvnrrl
       61 qqhlleirgl kdvnqrlqdd nqelrelccf ldddrqkgrk larewqrfgr haagavwhev
      121 arsqqklrel earqeallre nlelkelvll ldeeraalaa tgaasggggg gggagsrssi
      181 dsqaslsgpl sggapgagar dvgdgsstss agsggspdhh hhvpppllpp gphkapdgka
      241 gatrrslddl sapphhrsip nglhdpssty irqleskvrl legdkllaql prpygrprsw
      301 lqsspqa
//
LOCUS       XP_011535012             306 aa            linear   PRI 05-AUG-2025
DEFINITION  heterogeneous nuclear ribonucleoproteins C1/C2 isoform X1 [Homo
            sapiens].
ACCESSION   XP_011535012
VERSION     XP_011535012.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536710.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..306
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..306
                     /product="heterogeneous nuclear ribonucleoproteins C1/C2
                     isoform X1"
                     /calculated_mol_wt=33539
     Region          10..93
                     /region_name="RRM_hnRNPC"
                     /note="RNA recognition motif (RRM) found in vertebrate
                     heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP
                     C1/C2); cd12603"
                     /db_xref="CDD:410015"
     CDS             1..306
                     /gene="HNRNPC"
                     /gene_synonym="C1; C2; HNRNP; HNRPC; MRD74; SNRPC"
                     /coded_by="XM_011536710.3:918..1838"
                     /db_xref="GeneID:3183"
                     /db_xref="HGNC:HGNC:5035"
                     /db_xref="MIM:164020"
ORIGIN      
        1 masnvtnktd prsmnsrvfi gnlntlvvkk sdveaifsky gkivgcsvhk gfafvqyvne
       61 rnaraavage dgrmiagqvl dinlaaepkv nrgkagvkrs aaemygsvte hpspspllss
      121 sfdldydfqr dyydrmysyp arvpppppia ravvpskrqr vsgntsrrgk sgfnsksgqr
      181 gssksgklkg ddlqaikkel tqikqkvdsl lenlekieke qskqavemkn dkseeeqsss
      241 svkkdetnvk meseggadds aeegdllddd dnedrgddql elikddekea eegeddrdsa
      301 ngedds
//
LOCUS       XP_011535010             306 aa            linear   PRI 05-AUG-2025
DEFINITION  heterogeneous nuclear ribonucleoproteins C1/C2 isoform X1 [Homo
            sapiens].
ACCESSION   XP_011535010
VERSION     XP_011535010.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536708.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..306
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..306
                     /product="heterogeneous nuclear ribonucleoproteins C1/C2
                     isoform X1"
                     /calculated_mol_wt=33539
     Region          10..93
                     /region_name="RRM_hnRNPC"
                     /note="RNA recognition motif (RRM) found in vertebrate
                     heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP
                     C1/C2); cd12603"
                     /db_xref="CDD:410015"
     CDS             1..306
                     /gene="HNRNPC"
                     /gene_synonym="C1; C2; HNRNP; HNRPC; MRD74; SNRPC"
                     /coded_by="XM_011536708.2:296..1216"
                     /db_xref="GeneID:3183"
                     /db_xref="HGNC:HGNC:5035"
                     /db_xref="MIM:164020"
ORIGIN      
        1 masnvtnktd prsmnsrvfi gnlntlvvkk sdveaifsky gkivgcsvhk gfafvqyvne
       61 rnaraavage dgrmiagqvl dinlaaepkv nrgkagvkrs aaemygsvte hpspspllss
      121 sfdldydfqr dyydrmysyp arvpppppia ravvpskrqr vsgntsrrgk sgfnsksgqr
      181 gssksgklkg ddlqaikkel tqikqkvdsl lenlekieke qskqavemkn dkseeeqsss
      241 svkkdetnvk meseggadds aeegdllddd dnedrgddql elikddekea eegeddrdsa
      301 ngedds
//
LOCUS       XP_024305324             306 aa            linear   PRI 05-AUG-2025
DEFINITION  heterogeneous nuclear ribonucleoproteins C1/C2 isoform X1 [Homo
            sapiens].
ACCESSION   XP_024305324
VERSION     XP_024305324.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449556.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..306
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..306
                     /product="heterogeneous nuclear ribonucleoproteins C1/C2
                     isoform X1"
                     /calculated_mol_wt=33539
     Region          10..93
                     /region_name="RRM_hnRNPC"
                     /note="RNA recognition motif (RRM) found in vertebrate
                     heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP
                     C1/C2); cd12603"
                     /db_xref="CDD:410015"
     CDS             1..306
                     /gene="HNRNPC"
                     /gene_synonym="C1; C2; HNRNP; HNRPC; MRD74; SNRPC"
                     /coded_by="XM_024449556.2:1411..2331"
                     /db_xref="GeneID:3183"
                     /db_xref="HGNC:HGNC:5035"
                     /db_xref="MIM:164020"
ORIGIN      
        1 masnvtnktd prsmnsrvfi gnlntlvvkk sdveaifsky gkivgcsvhk gfafvqyvne
       61 rnaraavage dgrmiagqvl dinlaaepkv nrgkagvkrs aaemygsvte hpspspllss
      121 sfdldydfqr dyydrmysyp arvpppppia ravvpskrqr vsgntsrrgk sgfnsksgqr
      181 gssksgklkg ddlqaikkel tqikqkvdsl lenlekieke qskqavemkn dkseeeqsss
      241 svkkdetnvk meseggadds aeegdllddd dnedrgddql elikddekea eegeddrdsa
      301 ngedds
//
LOCUS       XP_011535011             306 aa            linear   PRI 05-AUG-2025
DEFINITION  heterogeneous nuclear ribonucleoproteins C1/C2 isoform X1 [Homo
            sapiens].
ACCESSION   XP_011535011
VERSION     XP_011535011.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536709.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..306
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..306
                     /product="heterogeneous nuclear ribonucleoproteins C1/C2
                     isoform X1"
                     /calculated_mol_wt=33539
     Region          10..93
                     /region_name="RRM_hnRNPC"
                     /note="RNA recognition motif (RRM) found in vertebrate
                     heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP
                     C1/C2); cd12603"
                     /db_xref="CDD:410015"
     CDS             1..306
                     /gene="HNRNPC"
                     /gene_synonym="C1; C2; HNRNP; HNRPC; MRD74; SNRPC"
                     /coded_by="XM_011536709.4:701..1621"
                     /db_xref="GeneID:3183"
                     /db_xref="HGNC:HGNC:5035"
                     /db_xref="MIM:164020"
ORIGIN      
        1 masnvtnktd prsmnsrvfi gnlntlvvkk sdveaifsky gkivgcsvhk gfafvqyvne
       61 rnaraavage dgrmiagqvl dinlaaepkv nrgkagvkrs aaemygsvte hpspspllss
      121 sfdldydfqr dyydrmysyp arvpppppia ravvpskrqr vsgntsrrgk sgfnsksgqr
      181 gssksgklkg ddlqaikkel tqikqkvdsl lenlekieke qskqavemkn dkseeeqsss
      241 svkkdetnvk meseggadds aeegdllddd dnedrgddql elikddekea eegeddrdsa
      301 ngedds
//
LOCUS       XP_024305325             306 aa            linear   PRI 05-AUG-2025
DEFINITION  heterogeneous nuclear ribonucleoproteins C1/C2 isoform X1 [Homo
            sapiens].
ACCESSION   XP_024305325
VERSION     XP_024305325.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449557.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..306
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..306
                     /product="heterogeneous nuclear ribonucleoproteins C1/C2
                     isoform X1"
                     /calculated_mol_wt=33539
     Region          10..93
                     /region_name="RRM_hnRNPC"
                     /note="RNA recognition motif (RRM) found in vertebrate
                     heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP
                     C1/C2); cd12603"
                     /db_xref="CDD:410015"
     CDS             1..306
                     /gene="HNRNPC"
                     /gene_synonym="C1; C2; HNRNP; HNRPC; MRD74; SNRPC"
                     /coded_by="XM_024449557.2:1418..2338"
                     /db_xref="GeneID:3183"
                     /db_xref="HGNC:HGNC:5035"
                     /db_xref="MIM:164020"
ORIGIN      
        1 masnvtnktd prsmnsrvfi gnlntlvvkk sdveaifsky gkivgcsvhk gfafvqyvne
       61 rnaraavage dgrmiagqvl dinlaaepkv nrgkagvkrs aaemygsvte hpspspllss
      121 sfdldydfqr dyydrmysyp arvpppppia ravvpskrqr vsgntsrrgk sgfnsksgqr
      181 gssksgklkg ddlqaikkel tqikqkvdsl lenlekieke qskqavemkn dkseeeqsss
      241 svkkdetnvk meseggadds aeegdllddd dnedrgddql elikddekea eegeddrdsa
      301 ngedds
//
LOCUS       XP_047287285             306 aa            linear   PRI 05-AUG-2025
DEFINITION  heterogeneous nuclear ribonucleoproteins C1/C2 isoform X1 [Homo
            sapiens].
ACCESSION   XP_047287285
VERSION     XP_047287285.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431329.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..306
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..306
                     /product="heterogeneous nuclear ribonucleoproteins C1/C2
                     isoform X1"
                     /calculated_mol_wt=33539
     Region          10..93
                     /region_name="RRM_hnRNPC"
                     /note="RNA recognition motif (RRM) found in vertebrate
                     heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP
                     C1/C2); cd12603"
                     /db_xref="CDD:410015"
     CDS             1..306
                     /gene="HNRNPC"
                     /gene_synonym="C1; C2; HNRNP; HNRPC; MRD74; SNRPC"
                     /coded_by="XM_047431329.1:5406..6326"
                     /db_xref="GeneID:3183"
                     /db_xref="HGNC:HGNC:5035"
                     /db_xref="MIM:164020"
ORIGIN      
        1 masnvtnktd prsmnsrvfi gnlntlvvkk sdveaifsky gkivgcsvhk gfafvqyvne
       61 rnaraavage dgrmiagqvl dinlaaepkv nrgkagvkrs aaemygsvte hpspspllss
      121 sfdldydfqr dyydrmysyp arvpppppia ravvpskrqr vsgntsrrgk sgfnsksgqr
      181 gssksgklkg ddlqaikkel tqikqkvdsl lenlekieke qskqavemkn dkseeeqsss
      241 svkkdetnvk meseggadds aeegdllddd dnedrgddql elikddekea eegeddrdsa
      301 ngedds
//
LOCUS       XP_024305326             293 aa            linear   PRI 05-AUG-2025
DEFINITION  heterogeneous nuclear ribonucleoproteins C1/C2 isoform X2 [Homo
            sapiens].
ACCESSION   XP_024305326
VERSION     XP_024305326.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449558.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..293
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..293
                     /product="heterogeneous nuclear ribonucleoproteins C1/C2
                     isoform X2"
                     /calculated_mol_wt=32206
     Region          10..93
                     /region_name="RRM_hnRNPC"
                     /note="RNA recognition motif (RRM) found in vertebrate
                     heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP
                     C1/C2); cd12603"
                     /db_xref="CDD:410015"
     CDS             1..293
                     /gene="HNRNPC"
                     /gene_synonym="C1; C2; HNRNP; HNRPC; MRD74; SNRPC"
                     /coded_by="XM_024449558.2:1411..2292"
                     /db_xref="GeneID:3183"
                     /db_xref="HGNC:HGNC:5035"
                     /db_xref="MIM:164020"
ORIGIN      
        1 masnvtnktd prsmnsrvfi gnlntlvvkk sdveaifsky gkivgcsvhk gfafvqyvne
       61 rnaraavage dgrmiagqvl dinlaaepkv nrgkagvkrs aaemygssfd ldydfqrdyy
      121 drmysyparv pppppiarav vpskrqrvsg ntsrrgksgf nsksgqrgss ksgklkgddl
      181 qaikkeltqi kqkvdsllen lekiekeqsk qavemkndks eeeqssssvk kdetnvkmes
      241 eggaddsaee gdllddddne drgddqleli kddekeaeeg eddrdsange dds
//
LOCUS       XP_006720188             293 aa            linear   PRI 05-AUG-2025
DEFINITION  heterogeneous nuclear ribonucleoproteins C1/C2 isoform X2 [Homo
            sapiens].
ACCESSION   XP_006720188
VERSION     XP_006720188.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720125.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..293
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..293
                     /product="heterogeneous nuclear ribonucleoproteins C1/C2
                     isoform X2"
                     /calculated_mol_wt=32206
     Region          10..93
                     /region_name="RRM_hnRNPC"
                     /note="RNA recognition motif (RRM) found in vertebrate
                     heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP
                     C1/C2); cd12603"
                     /db_xref="CDD:410015"
     CDS             1..293
                     /gene="HNRNPC"
                     /gene_synonym="C1; C2; HNRNP; HNRPC; MRD74; SNRPC"
                     /coded_by="XM_006720125.4:918..1799"
                     /db_xref="GeneID:3183"
                     /db_xref="HGNC:HGNC:5035"
                     /db_xref="MIM:164020"
ORIGIN      
        1 masnvtnktd prsmnsrvfi gnlntlvvkk sdveaifsky gkivgcsvhk gfafvqyvne
       61 rnaraavage dgrmiagqvl dinlaaepkv nrgkagvkrs aaemygssfd ldydfqrdyy
      121 drmysyparv pppppiarav vpskrqrvsg ntsrrgksgf nsksgqrgss ksgklkgddl
      181 qaikkeltqi kqkvdsllen lekiekeqsk qavemkndks eeeqssssvk kdetnvkmes
      241 eggaddsaee gdllddddne drgddqleli kddekeaeeg eddrdsange dds
//
LOCUS       XP_016876741             293 aa            linear   PRI 05-AUG-2025
DEFINITION  heterogeneous nuclear ribonucleoproteins C1/C2 isoform X2 [Homo
            sapiens].
ACCESSION   XP_016876741
VERSION     XP_016876741.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021252.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..293
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..293
                     /product="heterogeneous nuclear ribonucleoproteins C1/C2
                     isoform X2"
                     /calculated_mol_wt=32206
     Region          10..93
                     /region_name="RRM_hnRNPC"
                     /note="RNA recognition motif (RRM) found in vertebrate
                     heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP
                     C1/C2); cd12603"
                     /db_xref="CDD:410015"
     CDS             1..293
                     /gene="HNRNPC"
                     /gene_synonym="C1; C2; HNRNP; HNRPC; MRD74; SNRPC"
                     /coded_by="XM_017021252.3:925..1806"
                     /db_xref="GeneID:3183"
                     /db_xref="HGNC:HGNC:5035"
                     /db_xref="MIM:164020"
ORIGIN      
        1 masnvtnktd prsmnsrvfi gnlntlvvkk sdveaifsky gkivgcsvhk gfafvqyvne
       61 rnaraavage dgrmiagqvl dinlaaepkv nrgkagvkrs aaemygssfd ldydfqrdyy
      121 drmysyparv pppppiarav vpskrqrvsg ntsrrgksgf nsksgqrgss ksgklkgddl
      181 qaikkeltqi kqkvdsllen lekiekeqsk qavemkndks eeeqssssvk kdetnvkmes
      241 eggaddsaee gdllddddne drgddqleli kddekeaeeg eddrdsange dds
//
LOCUS       XP_011535014             293 aa            linear   PRI 05-AUG-2025
DEFINITION  heterogeneous nuclear ribonucleoproteins C1/C2 isoform X2 [Homo
            sapiens].
ACCESSION   XP_011535014
VERSION     XP_011535014.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536712.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..293
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..293
                     /product="heterogeneous nuclear ribonucleoproteins C1/C2
                     isoform X2"
                     /calculated_mol_wt=32206
     Region          10..93
                     /region_name="RRM_hnRNPC"
                     /note="RNA recognition motif (RRM) found in vertebrate
                     heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP
                     C1/C2); cd12603"
                     /db_xref="CDD:410015"
     CDS             1..293
                     /gene="HNRNPC"
                     /gene_synonym="C1; C2; HNRNP; HNRPC; MRD74; SNRPC"
                     /coded_by="XM_011536712.3:296..1177"
                     /db_xref="GeneID:3183"
                     /db_xref="HGNC:HGNC:5035"
                     /db_xref="MIM:164020"
ORIGIN      
        1 masnvtnktd prsmnsrvfi gnlntlvvkk sdveaifsky gkivgcsvhk gfafvqyvne
       61 rnaraavage dgrmiagqvl dinlaaepkv nrgkagvkrs aaemygssfd ldydfqrdyy
      121 drmysyparv pppppiarav vpskrqrvsg ntsrrgksgf nsksgqrgss ksgklkgddl
      181 qaikkeltqi kqkvdsllen lekiekeqsk qavemkndks eeeqssssvk kdetnvkmes
      241 eggaddsaee gdllddddne drgddqleli kddekeaeeg eddrdsange dds
//
LOCUS       XP_024305327             293 aa            linear   PRI 05-AUG-2025
DEFINITION  heterogeneous nuclear ribonucleoproteins C1/C2 isoform X2 [Homo
            sapiens].
ACCESSION   XP_024305327
VERSION     XP_024305327.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449559.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..293
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..293
                     /product="heterogeneous nuclear ribonucleoproteins C1/C2
                     isoform X2"
                     /calculated_mol_wt=32206
     Region          10..93
                     /region_name="RRM_hnRNPC"
                     /note="RNA recognition motif (RRM) found in vertebrate
                     heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP
                     C1/C2); cd12603"
                     /db_xref="CDD:410015"
     CDS             1..293
                     /gene="HNRNPC"
                     /gene_synonym="C1; C2; HNRNP; HNRPC; MRD74; SNRPC"
                     /coded_by="XM_024449559.2:1418..2299"
                     /db_xref="GeneID:3183"
                     /db_xref="HGNC:HGNC:5035"
                     /db_xref="MIM:164020"
ORIGIN      
        1 masnvtnktd prsmnsrvfi gnlntlvvkk sdveaifsky gkivgcsvhk gfafvqyvne
       61 rnaraavage dgrmiagqvl dinlaaepkv nrgkagvkrs aaemygssfd ldydfqrdyy
      121 drmysyparv pppppiarav vpskrqrvsg ntsrrgksgf nsksgqrgss ksgklkgddl
      181 qaikkeltqi kqkvdsllen lekiekeqsk qavemkndks eeeqssssvk kdetnvkmes
      241 eggaddsaee gdllddddne drgddqleli kddekeaeeg eddrdsange dds
//
LOCUS       XP_016876742             293 aa            linear   PRI 05-AUG-2025
DEFINITION  heterogeneous nuclear ribonucleoproteins C1/C2 isoform X2 [Homo
            sapiens].
ACCESSION   XP_016876742
VERSION     XP_016876742.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021253.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..293
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..293
                     /product="heterogeneous nuclear ribonucleoproteins C1/C2
                     isoform X2"
                     /calculated_mol_wt=32206
     Region          10..93
                     /region_name="RRM_hnRNPC"
                     /note="RNA recognition motif (RRM) found in vertebrate
                     heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP
                     C1/C2); cd12603"
                     /db_xref="CDD:410015"
     CDS             1..293
                     /gene="HNRNPC"
                     /gene_synonym="C1; C2; HNRNP; HNRPC; MRD74; SNRPC"
                     /coded_by="XM_017021253.3:701..1582"
                     /db_xref="GeneID:3183"
                     /db_xref="HGNC:HGNC:5035"
                     /db_xref="MIM:164020"
ORIGIN      
        1 masnvtnktd prsmnsrvfi gnlntlvvkk sdveaifsky gkivgcsvhk gfafvqyvne
       61 rnaraavage dgrmiagqvl dinlaaepkv nrgkagvkrs aaemygssfd ldydfqrdyy
      121 drmysyparv pppppiarav vpskrqrvsg ntsrrgksgf nsksgqrgss ksgklkgddl
      181 qaikkeltqi kqkvdsllen lekiekeqsk qavemkndks eeeqssssvk kdetnvkmes
      241 eggaddsaee gdllddddne drgddqleli kddekeaeeg eddrdsange dds
//
LOCUS       XP_047287286             293 aa            linear   PRI 05-AUG-2025
DEFINITION  heterogeneous nuclear ribonucleoproteins C1/C2 isoform X2 [Homo
            sapiens].
ACCESSION   XP_047287286
VERSION     XP_047287286.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431330.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..293
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..293
                     /product="heterogeneous nuclear ribonucleoproteins C1/C2
                     isoform X2"
                     /calculated_mol_wt=32206
     Region          10..93
                     /region_name="RRM_hnRNPC"
                     /note="RNA recognition motif (RRM) found in vertebrate
                     heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP
                     C1/C2); cd12603"
                     /db_xref="CDD:410015"
     CDS             1..293
                     /gene="HNRNPC"
                     /gene_synonym="C1; C2; HNRNP; HNRPC; MRD74; SNRPC"
                     /coded_by="XM_047431330.1:5413..6294"
                     /db_xref="GeneID:3183"
                     /db_xref="HGNC:HGNC:5035"
                     /db_xref="MIM:164020"
ORIGIN      
        1 masnvtnktd prsmnsrvfi gnlntlvvkk sdveaifsky gkivgcsvhk gfafvqyvne
       61 rnaraavage dgrmiagqvl dinlaaepkv nrgkagvkrs aaemygssfd ldydfqrdyy
      121 drmysyparv pppppiarav vpskrqrvsg ntsrrgksgf nsksgqrgss ksgklkgddl
      181 qaikkeltqi kqkvdsllen lekiekeqsk qavemkndks eeeqssssvk kdetnvkmes
      241 eggaddsaee gdllddddne drgddqleli kddekeaeeg eddrdsange dds
//
LOCUS       XP_047287287             293 aa            linear   PRI 05-AUG-2025
DEFINITION  heterogeneous nuclear ribonucleoproteins C1/C2 isoform X2 [Homo
            sapiens].
ACCESSION   XP_047287287
VERSION     XP_047287287.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431331.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..293
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..293
                     /product="heterogeneous nuclear ribonucleoproteins C1/C2
                     isoform X2"
                     /calculated_mol_wt=32206
     Region          10..93
                     /region_name="RRM_hnRNPC"
                     /note="RNA recognition motif (RRM) found in vertebrate
                     heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP
                     C1/C2); cd12603"
                     /db_xref="CDD:410015"
     CDS             1..293
                     /gene="HNRNPC"
                     /gene_synonym="C1; C2; HNRNP; HNRPC; MRD74; SNRPC"
                     /coded_by="XM_047431331.1:4696..5577"
                     /db_xref="GeneID:3183"
                     /db_xref="HGNC:HGNC:5035"
                     /db_xref="MIM:164020"
ORIGIN      
        1 masnvtnktd prsmnsrvfi gnlntlvvkk sdveaifsky gkivgcsvhk gfafvqyvne
       61 rnaraavage dgrmiagqvl dinlaaepkv nrgkagvkrs aaemygssfd ldydfqrdyy
      121 drmysyparv pppppiarav vpskrqrvsg ntsrrgksgf nsksgqrgss ksgklkgddl
      181 qaikkeltqi kqkvdsllen lekiekeqsk qavemkndks eeeqssssvk kdetnvkmes
      241 eggaddsaee gdllddddne drgddqleli kddekeaeeg eddrdsange dds
//
LOCUS       XP_047287288            1894 aa            linear   PRI 05-AUG-2025
DEFINITION  tetratricopeptide repeat protein 6 isoform X1 [Homo sapiens].
ACCESSION   XP_047287288
VERSION     XP_047287288.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431332.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1894
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1894
                     /product="tetratricopeptide repeat protein 6 isoform X1"
                     /calculated_mol_wt=217097
     Region          917..945
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          924..1816
                     /region_name="PEP_TPR_lipo"
                     /note="putative PEP-CTERM system TPR-repeat lipoprotein;
                     TIGR02917"
                     /db_xref="CDD:274350"
     Region          950..980
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          986..1013
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1018..1047
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(1053,1056..1057,1060..1061,1063,1087,1090..1091,
                     1094..1095,1097..1098,1121,1124..1125,1128,1131)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          1053..1080
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1085..1115
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1157..1183
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1191..1218
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(1193..1194,1197..1198,1201,1225,1228..1229,
                     1232..1233,1235..1236,1259,1262..1263,1266..1267,1270)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          1223..1253
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1292..1317
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1331..1354
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1370..1398
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1403..1432
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1447..1473
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(1449..1450,1453..1454,1456,1480,1483..1484,
                     1487..1488,1490..1491,1514,1517..1518,1521..1522,1525)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          1478..1508
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1513..1536
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1552..1578
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(1554..1555,1558..1559,1561,1585,1588..1589,
                     1592..1593,1595..1596,1619,1622..1623,1626..1627,1630)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          1583..1613
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1618..1648
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1655..1683
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1688..1718
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1722..>1891
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          1722..1750
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1758..1784
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(1760..1761,1764..1765,1767,1791,1794..1795,
                     1798..1799,1801..1802,1825,1828..1829,1832..1833,1836)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          1789..1819
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1824..1852
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1858..1886
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..1894
                     /gene="TTC6"
                     /gene_synonym="C14orf25; NCRNA00291"
                     /coded_by="XM_047431332.1:213..5897"
                     /db_xref="GeneID:319089"
                     /db_xref="HGNC:HGNC:19739"
                     /db_xref="MIM:620954"
ORIGIN      
        1 mstiprhfgl kykeesymfk elekvrqetk kdflrfkqkl askpavdesp vhslhapgpa
       61 rparvscaaa rtsrrypslk gpamsaaall qevlggaprp sglgeaaapg ktrsfrprdf
      121 ylrssaflrh qalkkppvia sgfgtarpvv llpppeppvk rrargvless rhaaprrvfh
      181 lgrereqsqe vaplagpcma kerkassvsa edgymeassg rrkvrirsnf vsesgarear
      241 eaaglgaqge qeswppsdar eaawqallps rviptsieei iaslqseaql asdqtikeli
      301 rsvlgqnydi tmedislmgk mylktspmqa etpeiqaeyk fqmgaeesqm svhkelsetm
      361 ssilqieqed iewgpseaes ivfkpqeisq vqpaeelskp ledgqptsds keakwvslta
      421 kspeflqieg keikrmrkrk slrprksskp lcdkklhkki pqdysmphlh dlcttipaqe
      481 lpvdlrlasr vyhtanrkgh dtllgkfgts flddrftdee qtdrilygip vmddnqeyvh
      541 ipptpqgipp elaqgtrera hkphlevlge emyaypeftk lfwntaapkf svpesvmket
      601 lypkyesvqa srlltdklsy kssvitlhqh srtnfwcflp rksasfesiq kwfsaqptql
      661 rrvkssvdlr kekiiaplei kndmqssike vmfqkakelk rqlqltkqnk teepnyvkes
      721 iddifdnmce khslrnlslt lieaskkagi syivypkkkk mrwkkrlkqq klifvheels
      781 kppkslersa shgilpgqkk ylfkvplyer qircpslply lnfekfvqak ggipenidpr
      841 twaldrliey kdasipvkek ddkisvpedp pervkeppkl klndyvesdl pqevikyyes
      901 evkilteein dktkypafay crrgaiyrkl gklqsamndl qrvilleplf lnaywhrhli
      961 ylfqdkinea lddlnyihky nknnteayls kaeiyrgkkd itlailnytq aikstptdad
     1021 iyfrrgemye itnkvlaidd fskcifydpk rtdallkrgl fycenenwfa aiedftalln
     1081 idhqnsqart yrgiayvkwk fykeatqdfs aaihldpnnw lalyyrgclf rksnpfralq
     1141 dysvsalind gyenlgcflh rgivyahlkl wllaicdfet vislertitl ayvniglihl
     1201 lhldnyteai wqfseairid plciqsylcr aetyfklhkl kkavnelsra ihlqpdgiql
     1261 yirrgqyllm mkyydlakft iyqiaemdkg lselspmqqa liysfcenhd kaievldgis
     1321 wnraemtmca llakvqmkak rtkeavevlk kaldaishsd kgpdataisa dclynlglcy
     1381 meegnlqmaf dsftkavkan pdfaesfyqr glckvklhkd ssildfnrai tlnpkhyqem
     1441 htgglgayls rvafyglkgr yskailncnk aikiypesvr aylyrgvlky ynktyklait
     1501 dlttaismdk nsytafynra lcytkirelq maltdygivl lldatetvkl ntflnrgliy
     1561 velgqygfal edfkqaalis rtngslchat amchhrinef eeavnfftwa lkinpcflda
     1621 yvgrgnsyme yghdeatkqa qkdflkalhi npayikaris fgynlqaqgk fqkawnhfti
     1681 aidtdpknyl ayegravvcl qmgnnfaamq dinaamkist taefltnrgv ihefmghkqn
     1741 amkdyqdait lnpkyslayf nagniyfhhr qfsqasdyfs kalkfdpene yvlmnraitn
     1801 tilkkyeeak edfanviesc pfwaavyfnr ahfyyclkqy elaeedlnka lslkpndalv
     1861 ynfrakvrgk iglieeamad ynqaldledy asvi
//
LOCUS       XP_047287289            1894 aa            linear   PRI 05-AUG-2025
DEFINITION  tetratricopeptide repeat protein 6 isoform X1 [Homo sapiens].
ACCESSION   XP_047287289
VERSION     XP_047287289.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431333.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1894
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1894
                     /product="tetratricopeptide repeat protein 6 isoform X1"
                     /calculated_mol_wt=217097
     Region          917..945
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          924..1816
                     /region_name="PEP_TPR_lipo"
                     /note="putative PEP-CTERM system TPR-repeat lipoprotein;
                     TIGR02917"
                     /db_xref="CDD:274350"
     Region          950..980
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          986..1013
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1018..1047
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(1053,1056..1057,1060..1061,1063,1087,1090..1091,
                     1094..1095,1097..1098,1121,1124..1125,1128,1131)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          1053..1080
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1085..1115
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1157..1183
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1191..1218
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(1193..1194,1197..1198,1201,1225,1228..1229,
                     1232..1233,1235..1236,1259,1262..1263,1266..1267,1270)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          1223..1253
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1292..1317
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1331..1354
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1370..1398
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1403..1432
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1447..1473
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(1449..1450,1453..1454,1456,1480,1483..1484,
                     1487..1488,1490..1491,1514,1517..1518,1521..1522,1525)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          1478..1508
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1513..1536
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1552..1578
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(1554..1555,1558..1559,1561,1585,1588..1589,
                     1592..1593,1595..1596,1619,1622..1623,1626..1627,1630)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          1583..1613
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1618..1648
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1655..1683
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1688..1718
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1722..>1891
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          1722..1750
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1758..1784
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(1760..1761,1764..1765,1767,1791,1794..1795,
                     1798..1799,1801..1802,1825,1828..1829,1832..1833,1836)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          1789..1819
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1824..1852
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1858..1886
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..1894
                     /gene="TTC6"
                     /gene_synonym="C14orf25; NCRNA00291"
                     /coded_by="XM_047431333.1:153..5837"
                     /db_xref="GeneID:319089"
                     /db_xref="HGNC:HGNC:19739"
                     /db_xref="MIM:620954"
ORIGIN      
        1 mstiprhfgl kykeesymfk elekvrqetk kdflrfkqkl askpavdesp vhslhapgpa
       61 rparvscaaa rtsrrypslk gpamsaaall qevlggaprp sglgeaaapg ktrsfrprdf
      121 ylrssaflrh qalkkppvia sgfgtarpvv llpppeppvk rrargvless rhaaprrvfh
      181 lgrereqsqe vaplagpcma kerkassvsa edgymeassg rrkvrirsnf vsesgarear
      241 eaaglgaqge qeswppsdar eaawqallps rviptsieei iaslqseaql asdqtikeli
      301 rsvlgqnydi tmedislmgk mylktspmqa etpeiqaeyk fqmgaeesqm svhkelsetm
      361 ssilqieqed iewgpseaes ivfkpqeisq vqpaeelskp ledgqptsds keakwvslta
      421 kspeflqieg keikrmrkrk slrprksskp lcdkklhkki pqdysmphlh dlcttipaqe
      481 lpvdlrlasr vyhtanrkgh dtllgkfgts flddrftdee qtdrilygip vmddnqeyvh
      541 ipptpqgipp elaqgtrera hkphlevlge emyaypeftk lfwntaapkf svpesvmket
      601 lypkyesvqa srlltdklsy kssvitlhqh srtnfwcflp rksasfesiq kwfsaqptql
      661 rrvkssvdlr kekiiaplei kndmqssike vmfqkakelk rqlqltkqnk teepnyvkes
      721 iddifdnmce khslrnlslt lieaskkagi syivypkkkk mrwkkrlkqq klifvheels
      781 kppkslersa shgilpgqkk ylfkvplyer qircpslply lnfekfvqak ggipenidpr
      841 twaldrliey kdasipvkek ddkisvpedp pervkeppkl klndyvesdl pqevikyyes
      901 evkilteein dktkypafay crrgaiyrkl gklqsamndl qrvilleplf lnaywhrhli
      961 ylfqdkinea lddlnyihky nknnteayls kaeiyrgkkd itlailnytq aikstptdad
     1021 iyfrrgemye itnkvlaidd fskcifydpk rtdallkrgl fycenenwfa aiedftalln
     1081 idhqnsqart yrgiayvkwk fykeatqdfs aaihldpnnw lalyyrgclf rksnpfralq
     1141 dysvsalind gyenlgcflh rgivyahlkl wllaicdfet vislertitl ayvniglihl
     1201 lhldnyteai wqfseairid plciqsylcr aetyfklhkl kkavnelsra ihlqpdgiql
     1261 yirrgqyllm mkyydlakft iyqiaemdkg lselspmqqa liysfcenhd kaievldgis
     1321 wnraemtmca llakvqmkak rtkeavevlk kaldaishsd kgpdataisa dclynlglcy
     1381 meegnlqmaf dsftkavkan pdfaesfyqr glckvklhkd ssildfnrai tlnpkhyqem
     1441 htgglgayls rvafyglkgr yskailncnk aikiypesvr aylyrgvlky ynktyklait
     1501 dlttaismdk nsytafynra lcytkirelq maltdygivl lldatetvkl ntflnrgliy
     1561 velgqygfal edfkqaalis rtngslchat amchhrinef eeavnfftwa lkinpcflda
     1621 yvgrgnsyme yghdeatkqa qkdflkalhi npayikaris fgynlqaqgk fqkawnhfti
     1681 aidtdpknyl ayegravvcl qmgnnfaamq dinaamkist taefltnrgv ihefmghkqn
     1741 amkdyqdait lnpkyslayf nagniyfhhr qfsqasdyfs kalkfdpene yvlmnraitn
     1801 tilkkyeeak edfanviesc pfwaavyfnr ahfyyclkqy elaeedlnka lslkpndalv
     1861 ynfrakvrgk iglieeamad ynqaldledy asvi
//
LOCUS       XP_016876743            1852 aa            linear   PRI 05-AUG-2025
DEFINITION  tetratricopeptide repeat protein 6 isoform X2 [Homo sapiens].
ACCESSION   XP_016876743
VERSION     XP_016876743.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021254.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1852
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1852
                     /product="tetratricopeptide repeat protein 6 isoform X2"
                     /calculated_mol_wt=212454
     Region          933..961
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          940..1755
                     /region_name="PEP_TPR_lipo"
                     /note="putative PEP-CTERM system TPR-repeat lipoprotein;
                     TIGR02917"
                     /db_xref="CDD:274350"
     Region          966..996
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1002..1029
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1034..1063
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(1069,1072..1073,1076..1077,1079,1103,1106..1107,
                     1110..1111,1113..1114,1137,1140..1141,1144,1147)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          1069..1096
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1101..1131
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1173..1199
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1207..1234
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(1209..1210,1213..1214,1217,1241,1244..1245,
                     1248..1249,1251..1252,1275,1278..1279,1282..1283,1286)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          1239..1269
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1308..1333
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1347..1370
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1386..1431
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(1387,1390..1391,1394..1395,1397,1438,1441..1442,
                     1445..1446,1448..1449,1472,1475..1476,1479..1480,1483)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          1436..1466
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1471..1494
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1510..1536
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(1512..1513,1516..1517,1519,1543,1546..1547,
                     1550..1551,1553..1554,1577,1580..1581,1584..1585,1588)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          1541..1571
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1576..1606
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1613..1641
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1646..1676
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1680..>1849
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          1680..1708
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1716..1742
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(1718..1719,1722..1723,1725,1749,1752..1753,
                     1756..1757,1759..1760,1783,1786..1787,1790..1791,1794)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          1747..1777
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1782..1810
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1816..1844
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..1852
                     /gene="TTC6"
                     /gene_synonym="C14orf25; NCRNA00291"
                     /coded_by="XM_017021254.2:428..5986"
                     /db_xref="GeneID:319089"
                     /db_xref="HGNC:HGNC:19739"
                     /db_xref="MIM:620954"
ORIGIN      
        1 mrrgtrihgs evkfvkmsti prhfglkyke esymfkelek vrqetkkdfl rfkqklaskp
       61 avdespvhsl hapgparpar vscaaartsr rypslkgpam saaallqevl ggaprpsglg
      121 eaaapgktrs frprdfylrs saflrhqalk kppviasgfg tarpvvllpp peppvkrrar
      181 gvlessrhaa prrvfhlgre reqsqevapl agpcmakerk assvsaedgy meassgrrkv
      241 rirsnfvses gareareaag lgaqgeqesw ppsdareaaw qallpsrvip tsieeiiasl
      301 qseaqlasdq tikelirsvl gqnyditmed islmgkmylk tspmqaetpe iqaeykfqmg
      361 aeesqmsvhk elsetmssil qieqediewg pseaesivfk pqeisqvqpa eelskpledg
      421 qptsdskeak wvsltakspe flqiegkeik rmrkrkslrp rksskplcdk klhkkipqdy
      481 smphlhdlct tipaqelpvd lrlasrvyht anrkghdtll gkfgtsfldd rftdeeqtdr
      541 ilygipvmdd nqeyvhippt pqgippelaq gtrerahkph levlgeemya ypeftklfwn
      601 taapkfsvpe svmketlypk yesvqasrll tdklsykssv itlhqhsrtn fwcflprksa
      661 sfesiqkwfs aqptqlrrvk ssvdlrkeki iapleikndm qssikevmfq kakelkrqlq
      721 ltkqnkteep nyvkesiddi fdnmcekhsl rnlsltliea skkagisyiv ypkkkkmrwk
      781 krlkqqklif vheelskppk slersashgi lpgqkkylfk vplyerqirc pslplylnfe
      841 kfvqakggip enidprtwal drlieykdas ipvkekddki svpedpperv keppklklnd
      901 yvesdlpqev ikyyesevki lteeindktk ypafaycrrg aiyrklgklq samndlqrvi
      961 lleplflnay whrhliylfq dkinealddl nyihkynknn teaylskaei yrgkkditla
     1021 ilnytqaiks tptdadiyfr rgemyeitnk vlaiddfskc ifydpkrtda llkrglfyce
     1081 nenwfaaied ftallnidhq nsqartyrgi ayvkwkfyke atqdfsaaih ldpnnwlaly
     1141 yrgclfrksn pfralqdysv salindgyen lgcflhrgiv yahlklwlla icdfetvisl
     1201 ertitlayvn iglihllhld nyteaiwqfs eairidplci qsylcraety fklhklkkav
     1261 nelsraihlq pdgiqlyirr gqyllmmkyy dlakftiyqi aemdkglsel spmqqaliys
     1321 fcenhdkaie vldgiswnra emtmcallak vqmkakrtke avevlkkald aishsdkgpd
     1381 ataisadcly nlglcymeeg nlqmaylsrv afyglkgrys kailncnkai kiypesvray
     1441 lyrgvlkyyn ktyklaitdl ttaismdkns ytafynralc ytkirelqma ltdygivlll
     1501 datetvklnt flnrgliyve lgqygfaled fkqaalisrt ngslchatam chhrinefee
     1561 avnfftwalk inpcfldayv grgnsymeyg hdeatkqaqk dflkalhinp ayikarisfg
     1621 ynlqaqgkfq kawnhftiai dtdpknylay egravvclqm gnnfaamqdi naamkistta
     1681 efltnrgvih efmghkqnam kdyqdaitln pkyslayfna gniyfhhrqf sqasdyfska
     1741 lkfdpeneyv lmnraitnti lkkyeeaked fanviescpf waavyfnrah fyyclkqyel
     1801 aeedlnkals lkpndalvyn frakvrgkig lieeamadyn qaldledyas vi
//
LOCUS       XP_016876744            1807 aa            linear   PRI 05-AUG-2025
DEFINITION  tetratricopeptide repeat protein 6 isoform X3 [Homo sapiens].
ACCESSION   XP_016876744
VERSION     XP_016876744.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021255.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1807
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1807
                     /product="tetratricopeptide repeat protein 6 isoform X3"
                     /calculated_mol_wt=207644
     Region          933..961
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          940..1748
                     /region_name="PEP_TPR_lipo"
                     /note="putative PEP-CTERM system TPR-repeat lipoprotein;
                     TIGR02917"
                     /db_xref="CDD:274350"
     Region          966..996
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1002..1029
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1034..1063
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(1069,1072..1073,1076..1077,1079,1103,1106..1107,
                     1110..1111,1113..1114,1137,1140..1141,1144,1147)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          1069..1096
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1101..1131
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1173..1199
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1207..1234
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(1209..1210,1213..1214,1217,1241,1244..1245,
                     1248..1249,1251..1252,1275,1278..1279,1282..1283,1286)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          1239..1269
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1308..1333
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(1359,1362..1363,1366..1367,1369,1393,1396..1397,
                     1400..1401,1403..1404,1427,1430..1431,1434..1435,1438)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          1359..1386
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1391..1421
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1426..1449
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1465..1491
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(1467..1468,1471..1472,1474,1498,1501..1502,
                     1505..1506,1508..1509,1532,1535..1536,1539..1540,1543)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          1496..1526
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1531..1561
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1568..1596
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1601..1631
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1635..>1804
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          1635..1663
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1671..1697
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(1673..1674,1677..1678,1680,1704,1707..1708,
                     1711..1712,1714..1715,1738,1741..1742,1745..1746,1749)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          1702..1732
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1737..1765
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1771..1799
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..1807
                     /gene="TTC6"
                     /gene_synonym="C14orf25; NCRNA00291"
                     /coded_by="XM_017021255.2:428..5851"
                     /db_xref="GeneID:319089"
                     /db_xref="HGNC:HGNC:19739"
                     /db_xref="MIM:620954"
ORIGIN      
        1 mrrgtrihgs evkfvkmsti prhfglkyke esymfkelek vrqetkkdfl rfkqklaskp
       61 avdespvhsl hapgparpar vscaaartsr rypslkgpam saaallqevl ggaprpsglg
      121 eaaapgktrs frprdfylrs saflrhqalk kppviasgfg tarpvvllpp peppvkrrar
      181 gvlessrhaa prrvfhlgre reqsqevapl agpcmakerk assvsaedgy meassgrrkv
      241 rirsnfvses gareareaag lgaqgeqesw ppsdareaaw qallpsrvip tsieeiiasl
      301 qseaqlasdq tikelirsvl gqnyditmed islmgkmylk tspmqaetpe iqaeykfqmg
      361 aeesqmsvhk elsetmssil qieqediewg pseaesivfk pqeisqvqpa eelskpledg
      421 qptsdskeak wvsltakspe flqiegkeik rmrkrkslrp rksskplcdk klhkkipqdy
      481 smphlhdlct tipaqelpvd lrlasrvyht anrkghdtll gkfgtsfldd rftdeeqtdr
      541 ilygipvmdd nqeyvhippt pqgippelaq gtrerahkph levlgeemya ypeftklfwn
      601 taapkfsvpe svmketlypk yesvqasrll tdklsykssv itlhqhsrtn fwcflprksa
      661 sfesiqkwfs aqptqlrrvk ssvdlrkeki iapleikndm qssikevmfq kakelkrqlq
      721 ltkqnkteep nyvkesiddi fdnmcekhsl rnlsltliea skkagisyiv ypkkkkmrwk
      781 krlkqqklif vheelskppk slersashgi lpgqkkylfk vplyerqirc pslplylnfe
      841 kfvqakggip enidprtwal drlieykdas ipvkekddki svpedpperv keppklklnd
      901 yvesdlpqev ikyyesevki lteeindktk ypafaycrrg aiyrklgklq samndlqrvi
      961 lleplflnay whrhliylfq dkinealddl nyihkynknn teaylskaei yrgkkditla
     1021 ilnytqaiks tptdadiyfr rgemyeitnk vlaiddfskc ifydpkrtda llkrglfyce
     1081 nenwfaaied ftallnidhq nsqartyrgi ayvkwkfyke atqdfsaaih ldpnnwlaly
     1141 yrgclfrksn pfralqdysv salindgyen lgcflhrgiv yahlklwlla icdfetvisl
     1201 ertitlayvn iglihllhld nyteaiwqfs eairidplci qsylcraety fklhklkkav
     1261 nelsraihlq pdgiqlyirr gqyllmmkyy dlakftiyqi aemdkglsel spmqqaliys
     1321 fcenhdkaie vldgiswnra emtmcallak vqmkakrtka ylsrvafygl kgryskailn
     1381 cnkaikiype svraylyrgv lkyynktykl aitdlttais mdknsytafy nralcytkir
     1441 elqmaltdyg ivllldatet vklntflnrg liyvelgqyg faledfkqaa lisrtngslc
     1501 hatamchhri nefeeavnff twalkinpcf ldayvgrgns ymeyghdeat kqaqkdflka
     1561 lhinpayika risfgynlqa qgkfqkawnh ftiaidtdpk nylayegrav vclqmgnnfa
     1621 amqdinaamk isttaefltn rgvihefmgh kqnamkdyqd aitlnpkysl ayfnagniyf
     1681 hhrqfsqasd yfskalkfdp eneyvlmnra itntilkkye eakedfanvi escpfwaavy
     1741 fnrahfyycl kqyelaeedl nkalslkpnd alvynfrakv rgkiglieea madynqaldl
     1801 edyasvi
//
LOCUS       XP_016876745            1577 aa            linear   PRI 05-AUG-2025
DEFINITION  tetratricopeptide repeat protein 6 isoform X4 [Homo sapiens].
ACCESSION   XP_016876745
VERSION     XP_016876745.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021256.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1577
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1577
                     /product="tetratricopeptide repeat protein 6 isoform X4"
                     /calculated_mol_wt=182376
     Region          600..628
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          607..1499
                     /region_name="PEP_TPR_lipo"
                     /note="putative PEP-CTERM system TPR-repeat lipoprotein;
                     TIGR02917"
                     /db_xref="CDD:274350"
     Region          633..663
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          669..696
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          701..730
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(736,739..740,743..744,746,770,773..774,777..778,
                     780..781,804,807..808,811,814)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          736..763
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          768..798
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          840..866
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          874..901
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(876..877,880..881,884,908,911..912,915..916,
                     918..919,942,945..946,949..950,953)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          906..936
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          975..1000
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1014..1037
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1053..1081
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1086..1115
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1130..1156
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(1132..1133,1136..1137,1139,1163,1166..1167,
                     1170..1171,1173..1174,1197,1200..1201,1204..1205,1208)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          1161..1191
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1196..1219
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1235..1261
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(1237..1238,1241..1242,1244,1268,1271..1272,
                     1275..1276,1278..1279,1302,1305..1306,1309..1310,1313)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          1266..1296
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1301..1331
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1338..1366
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1371..1401
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1405..>1574
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          1405..1433
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1441..1467
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(1443..1444,1447..1448,1450,1474,1477..1478,
                     1481..1482,1484..1485,1508,1511..1512,1515..1516,1519)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          1472..1502
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1507..1535
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1541..1569
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..1577
                     /gene="TTC6"
                     /gene_synonym="C14orf25; NCRNA00291"
                     /coded_by="XM_017021256.2:1952..6685"
                     /db_xref="GeneID:319089"
                     /db_xref="HGNC:HGNC:19739"
                     /db_xref="MIM:620954"
ORIGIN      
        1 mgkmylktsp mqaetpeiqa eykfqmgaee sqmsvhkels etmssilqie qediewgpse
       61 aesivfkpqe isqvqpaeel skpledgqpt sdskeakwvs ltakspeflq iegkeikrmr
      121 krkslrprks skplcdkklh kkipqdysmp hlhdlcttip aqelpvdlrl asrvyhtanr
      181 kghdtllgkf gtsflddrft deeqtdrily gipvmddnqe yvhipptpqg ippelaqgtr
      241 erahkphlev lgeemyaype ftklfwntaa pkfsvpesvm ketlypkyes vqasrlltdk
      301 lsykssvitl hqhsrtnfwc flprksasfe siqkwfsaqp tqlrrvkssv dlrkekiiap
      361 leikndmqss ikevmfqkak elkrqlqltk qnkteepnyv kesiddifdn mcekhslrnl
      421 sltlieaskk agisyivypk kkkmrwkkrl kqqklifvhe elskppksle rsashgilpg
      481 qkkylfkvpl yerqircpsl plylnfekfv qakggipeni dprtwaldrl ieykdasipv
      541 kekddkisvp edppervkep pklklndyve sdlpqeviky yesevkilte eindktkypa
      601 faycrrgaiy rklgklqsam ndlqrville plflnaywhr hliylfqdki nealddlnyi
      661 hkynknntea ylskaeiyrg kkditlailn ytqaikstpt dadiyfrrge myeitnkvla
      721 iddfskcify dpkrtdallk rglfycenen wfaaiedfta llnidhqnsq artyrgiayv
      781 kwkfykeatq dfsaaihldp nnwlalyyrg clfrksnpfr alqdysvsal indgyenlgc
      841 flhrgivyah lklwllaicd fetvislert itlayvnigl ihllhldnyt eaiwqfseai
      901 ridplciqsy lcraetyfkl hklkkavnel sraihlqpdg iqlyirrgqy llmmkyydla
      961 kftiyqiaem dkglselspm qqaliysfce nhdkaievld giswnraemt mcallakvqm
     1021 kakrtkeave vlkkaldais hsdkgpdata isadclynlg lcymeegnlq mafdsftkav
     1081 kanpdfaesf yqrglckvkl hkdssildfn raitlnpkhy qemhtgglga ylsrvafygl
     1141 kgryskailn cnkaikiype svraylyrgv lkyynktykl aitdlttais mdknsytafy
     1201 nralcytkir elqmaltdyg ivllldatet vklntflnrg liyvelgqyg faledfkqaa
     1261 lisrtngslc hatamchhri nefeeavnff twalkinpcf ldayvgrgns ymeyghdeat
     1321 kqaqkdflka lhinpayika risfgynlqa qgkfqkawnh ftiaidtdpk nylayegrav
     1381 vclqmgnnfa amqdinaamk isttaefltn rgvihefmgh kqnamkdyqd aitlnpkysl
     1441 ayfnagniyf hhrqfsqasd yfskalkfdp eneyvlmnra itntilkkye eakedfanvi
     1501 escpfwaavy fnrahfyycl kqyelaeedl nkalslkpnd alvynfrakv rgkiglieea
     1561 madynqaldl edyasvi
//
LOCUS       XP_047287290            1577 aa            linear   PRI 05-AUG-2025
DEFINITION  tetratricopeptide repeat protein 6 isoform X4 [Homo sapiens].
ACCESSION   XP_047287290
VERSION     XP_047287290.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431334.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1577
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1577
                     /product="tetratricopeptide repeat protein 6 isoform X4"
                     /calculated_mol_wt=182376
     Region          600..628
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          607..1499
                     /region_name="PEP_TPR_lipo"
                     /note="putative PEP-CTERM system TPR-repeat lipoprotein;
                     TIGR02917"
                     /db_xref="CDD:274350"
     Region          633..663
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          669..696
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          701..730
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(736,739..740,743..744,746,770,773..774,777..778,
                     780..781,804,807..808,811,814)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          736..763
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          768..798
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          840..866
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          874..901
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(876..877,880..881,884,908,911..912,915..916,
                     918..919,942,945..946,949..950,953)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          906..936
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          975..1000
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1014..1037
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1053..1081
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1086..1115
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1130..1156
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(1132..1133,1136..1137,1139,1163,1166..1167,
                     1170..1171,1173..1174,1197,1200..1201,1204..1205,1208)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          1161..1191
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1196..1219
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1235..1261
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(1237..1238,1241..1242,1244,1268,1271..1272,
                     1275..1276,1278..1279,1302,1305..1306,1309..1310,1313)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          1266..1296
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1301..1331
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1338..1366
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1371..1401
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1405..>1574
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          1405..1433
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1441..1467
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(1443..1444,1447..1448,1450,1474,1477..1478,
                     1481..1482,1484..1485,1508,1511..1512,1515..1516,1519)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          1472..1502
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1507..1535
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1541..1569
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..1577
                     /gene="TTC6"
                     /gene_synonym="C14orf25; NCRNA00291"
                     /coded_by="XM_047431334.1:67..4800"
                     /db_xref="GeneID:319089"
                     /db_xref="HGNC:HGNC:19739"
                     /db_xref="MIM:620954"
ORIGIN      
        1 mgkmylktsp mqaetpeiqa eykfqmgaee sqmsvhkels etmssilqie qediewgpse
       61 aesivfkpqe isqvqpaeel skpledgqpt sdskeakwvs ltakspeflq iegkeikrmr
      121 krkslrprks skplcdkklh kkipqdysmp hlhdlcttip aqelpvdlrl asrvyhtanr
      181 kghdtllgkf gtsflddrft deeqtdrily gipvmddnqe yvhipptpqg ippelaqgtr
      241 erahkphlev lgeemyaype ftklfwntaa pkfsvpesvm ketlypkyes vqasrlltdk
      301 lsykssvitl hqhsrtnfwc flprksasfe siqkwfsaqp tqlrrvkssv dlrkekiiap
      361 leikndmqss ikevmfqkak elkrqlqltk qnkteepnyv kesiddifdn mcekhslrnl
      421 sltlieaskk agisyivypk kkkmrwkkrl kqqklifvhe elskppksle rsashgilpg
      481 qkkylfkvpl yerqircpsl plylnfekfv qakggipeni dprtwaldrl ieykdasipv
      541 kekddkisvp edppervkep pklklndyve sdlpqeviky yesevkilte eindktkypa
      601 faycrrgaiy rklgklqsam ndlqrville plflnaywhr hliylfqdki nealddlnyi
      661 hkynknntea ylskaeiyrg kkditlailn ytqaikstpt dadiyfrrge myeitnkvla
      721 iddfskcify dpkrtdallk rglfycenen wfaaiedfta llnidhqnsq artyrgiayv
      781 kwkfykeatq dfsaaihldp nnwlalyyrg clfrksnpfr alqdysvsal indgyenlgc
      841 flhrgivyah lklwllaicd fetvislert itlayvnigl ihllhldnyt eaiwqfseai
      901 ridplciqsy lcraetyfkl hklkkavnel sraihlqpdg iqlyirrgqy llmmkyydla
      961 kftiyqiaem dkglselspm qqaliysfce nhdkaievld giswnraemt mcallakvqm
     1021 kakrtkeave vlkkaldais hsdkgpdata isadclynlg lcymeegnlq mafdsftkav
     1081 kanpdfaesf yqrglckvkl hkdssildfn raitlnpkhy qemhtgglga ylsrvafygl
     1141 kgryskailn cnkaikiype svraylyrgv lkyynktykl aitdlttais mdknsytafy
     1201 nralcytkir elqmaltdyg ivllldatet vklntflnrg liyvelgqyg faledfkqaa
     1261 lisrtngslc hatamchhri nefeeavnff twalkinpcf ldayvgrgns ymeyghdeat
     1321 kqaqkdflka lhinpayika risfgynlqa qgkfqkawnh ftiaidtdpk nylayegrav
     1381 vclqmgnnfa amqdinaamk isttaefltn rgvihefmgh kqnamkdyqd aitlnpkysl
     1441 ayfnagniyf hhrqfsqasd yfskalkfdp eneyvlmnra itntilkkye eakedfanvi
     1501 escpfwaavy fnrahfyycl kqyelaeedl nkalslkpnd alvynfrakv rgkiglieea
     1561 madynqaldl edyasvi
//
LOCUS       XP_047287291            1372 aa            linear   PRI 05-AUG-2025
DEFINITION  tetratricopeptide repeat protein 6 isoform X5 [Homo sapiens].
ACCESSION   XP_047287291
VERSION     XP_047287291.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431335.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1372
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1372
                     /product="tetratricopeptide repeat protein 6 isoform X5"
                     /calculated_mol_wt=157579
     Region          <933..1034
                     /region_name="BepA"
                     /note="Outer membrane protein chaperone/metalloprotease
                     BepA/YfgC, contains M48 and TPR domains [Cell
                     wall/membrane/envelope biogenesis, Posttranslational
                     modification, protein turnover, chaperones]; COG4783"
                     /db_xref="CDD:443813"
     Region          933..961
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          966..996
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          995..>1158
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          1002..1029
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1034..1063
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(1069,1072..1073,1076..1077,1079,1103,1106..1107,
                     1110..1111,1113..1114,1137,1140..1141,1144,1147)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          1069..1096
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1095..1328
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          1101..1131
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1173..1199
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1207..1234
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(1209..1210,1213..1214,1217,1241,1244..1245,
                     1248..1249,1251..1252,1275,1278..1279,1282..1283,1286)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          1239..1269
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1308..1333
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..1372
                     /gene="TTC6"
                     /gene_synonym="C14orf25; NCRNA00291"
                     /coded_by="XM_047431335.1:428..4546"
                     /db_xref="GeneID:319089"
                     /db_xref="HGNC:HGNC:19739"
                     /db_xref="MIM:620954"
ORIGIN      
        1 mrrgtrihgs evkfvkmsti prhfglkyke esymfkelek vrqetkkdfl rfkqklaskp
       61 avdespvhsl hapgparpar vscaaartsr rypslkgpam saaallqevl ggaprpsglg
      121 eaaapgktrs frprdfylrs saflrhqalk kppviasgfg tarpvvllpp peppvkrrar
      181 gvlessrhaa prrvfhlgre reqsqevapl agpcmakerk assvsaedgy meassgrrkv
      241 rirsnfvses gareareaag lgaqgeqesw ppsdareaaw qallpsrvip tsieeiiasl
      301 qseaqlasdq tikelirsvl gqnyditmed islmgkmylk tspmqaetpe iqaeykfqmg
      361 aeesqmsvhk elsetmssil qieqediewg pseaesivfk pqeisqvqpa eelskpledg
      421 qptsdskeak wvsltakspe flqiegkeik rmrkrkslrp rksskplcdk klhkkipqdy
      481 smphlhdlct tipaqelpvd lrlasrvyht anrkghdtll gkfgtsfldd rftdeeqtdr
      541 ilygipvmdd nqeyvhippt pqgippelaq gtrerahkph levlgeemya ypeftklfwn
      601 taapkfsvpe svmketlypk yesvqasrll tdklsykssv itlhqhsrtn fwcflprksa
      661 sfesiqkwfs aqptqlrrvk ssvdlrkeki iapleikndm qssikevmfq kakelkrqlq
      721 ltkqnkteep nyvkesiddi fdnmcekhsl rnlsltliea skkagisyiv ypkkkkmrwk
      781 krlkqqklif vheelskppk slersashgi lpgqkkylfk vplyerqirc pslplylnfe
      841 kfvqakggip enidprtwal drlieykdas ipvkekddki svpedpperv keppklklnd
      901 yvesdlpqev ikyyesevki lteeindktk ypafaycrrg aiyrklgklq samndlqrvi
      961 lleplflnay whrhliylfq dkinealddl nyihkynknn teaylskaei yrgkkditla
     1021 ilnytqaiks tptdadiyfr rgemyeitnk vlaiddfskc ifydpkrtda llkrglfyce
     1081 nenwfaaied ftallnidhq nsqartyrgi ayvkwkfyke atqdfsaaih ldpnnwlaly
     1141 yrgclfrksn pfralqdysv salindgyen lgcflhrgiv yahlklwlla icdfetvisl
     1201 ertitlayvn iglihllhld nyteaiwqfs eairidplci qsylcraety fklhklkkav
     1261 nelsraihlq pdgiqlyirr gqyllmmkyy dlakftiyqi aemdkglsel spmqqaliys
     1321 fcenhdkaie vldgiswnra emtmcallak vqmkakrtkg rgwswkplss an
//
LOCUS       XP_011535733            1323 aa            linear   PRI 05-AUG-2025
DEFINITION  tetratricopeptide repeat protein 6 isoform X6 [Homo sapiens].
ACCESSION   XP_011535733
VERSION     XP_011535733.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537431.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1323
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1323
                     /product="tetratricopeptide repeat protein 6 isoform X6"
                     /calculated_mol_wt=153364
     Region          346..374
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          353..1245
                     /region_name="PEP_TPR_lipo"
                     /note="putative PEP-CTERM system TPR-repeat lipoprotein;
                     TIGR02917"
                     /db_xref="CDD:274350"
     Region          379..409
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          415..442
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          447..476
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(482,485..486,489..490,492,516,519..520,523..524,
                     526..527,550,553..554,557,560)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          482..509
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          514..544
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          586..612
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          620..647
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(622..623,626..627,630,654,657..658,661..662,
                     664..665,688,691..692,695..696,699)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          652..682
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          721..746
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          760..783
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          799..827
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          832..861
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          876..902
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(878..879,882..883,885,909,912..913,916..917,
                     919..920,943,946..947,950..951,954)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          907..937
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          942..965
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          981..1007
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(983..984,987..988,990,1014,1017..1018,1021..1022,
                     1024..1025,1048,1051..1052,1055..1056,1059)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          1012..1042
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1047..1077
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1084..1112
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1117..1147
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1151..>1320
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          1151..1179
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1187..1213
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(1189..1190,1193..1194,1196,1220,1223..1224,
                     1227..1228,1230..1231,1254,1257..1258,1261..1262,1265)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          1218..1248
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1253..1281
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1287..1315
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..1323
                     /gene="TTC6"
                     /gene_synonym="C14orf25; NCRNA00291"
                     /coded_by="XM_011537431.3:84..4055"
                     /db_xref="GeneID:319089"
                     /db_xref="HGNC:HGNC:19739"
                     /db_xref="MIM:620954"
ORIGIN      
        1 myaypeftkl fwntaapkfs vpesvmketl ypkyesvqas rlltdklsyk ssvitlhqhs
       61 rtnfwcflpr ksasfesiqk wfsaqptqlr rvkssvdlrk ekiiapleik ndmqssikev
      121 mfqkakelkr qlqltkqnkt eepnyvkesi ddifdnmcek hslrnlsltl ieaskkagis
      181 yivypkkkkm rwkkrlkqqk lifvheelsk ppkslersas hgilpgqkky lfkvplyerq
      241 ircpslplyl nfekfvqakg gipenidprt waldrlieyk dasipvkekd dkisvpedpp
      301 ervkeppklk lndyvesdlp qevikyyese vkilteeind ktkypafayc rrgaiyrklg
      361 klqsamndlq rvilleplfl naywhrhliy lfqdkineal ddlnyihkyn knnteaylsk
      421 aeiyrgkkdi tlailnytqa ikstptdadi yfrrgemyei tnkvlaiddf skcifydpkr
      481 tdallkrglf ycenenwfaa iedftallni dhqnsqarty rgiayvkwkf ykeatqdfsa
      541 aihldpnnwl alyyrgclfr ksnpfralqd ysvsalindg yenlgcflhr givyahlklw
      601 llaicdfetv islertitla yvniglihll hldnyteaiw qfseairidp lciqsylcra
      661 etyfklhklk kavnelsrai hlqpdgiqly irrgqyllmm kyydlakfti yqiaemdkgl
      721 selspmqqal iysfcenhdk aievldgisw nraemtmcal lakvqmkakr tkeavevlkk
      781 aldaishsdk gpdataisad clynlglcym eegnlqmafd sftkavkanp dfaesfyqrg
      841 lckvklhkds sildfnrait lnpkhyqemh tgglgaylsr vafyglkgry skailncnka
      901 ikiypesvra ylyrgvlkyy nktyklaitd lttaismdkn sytafynral cytkirelqm
      961 altdygivll ldatetvkln tflnrgliyv elgqygfale dfkqaalisr tngslchata
     1021 mchhrinefe eavnfftwal kinpcflday vgrgnsymey ghdeatkqaq kdflkalhin
     1081 payikarisf gynlqaqgkf qkawnhftia idtdpknyla yegravvclq mgnnfaamqd
     1141 inaamkistt aefltnrgvi hefmghkqna mkdyqdaitl npkyslayfn agniyfhhrq
     1201 fsqasdyfsk alkfdpeney vlmnraitnt ilkkyeeake dfanviescp fwaavyfnra
     1261 hfyyclkqye laeedlnkal slkpndalvy nfrakvrgki glieeamady nqaldledya
     1321 svi
//
LOCUS       XP_011535734            1164 aa            linear   PRI 05-AUG-2025
DEFINITION  tetratricopeptide repeat protein 6 isoform X7 [Homo sapiens].
ACCESSION   XP_011535734
VERSION     XP_011535734.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537432.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1164
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1164
                     /product="tetratricopeptide repeat protein 6 isoform X7"
                     /calculated_mol_wt=133513
     Region          <933..1034
                     /region_name="BepA"
                     /note="Outer membrane protein chaperone/metalloprotease
                     BepA/YfgC, contains M48 and TPR domains [Cell
                     wall/membrane/envelope biogenesis, Posttranslational
                     modification, protein turnover, chaperones]; COG4783"
                     /db_xref="CDD:443813"
     Region          933..961
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          966..996
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          995..>1158
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          1002..1029
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1034..1063
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(1069,1072..1073,1076..1077,1079,1103,1106..1107,
                     1110..1111,1113..1114,1137,1140..1141,1144,1147)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          1069..1096
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1101..1131
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..1164
                     /gene="TTC6"
                     /gene_synonym="C14orf25; NCRNA00291"
                     /coded_by="XM_011537432.3:428..3922"
                     /db_xref="GeneID:319089"
                     /db_xref="HGNC:HGNC:19739"
                     /db_xref="MIM:620954"
ORIGIN      
        1 mrrgtrihgs evkfvkmsti prhfglkyke esymfkelek vrqetkkdfl rfkqklaskp
       61 avdespvhsl hapgparpar vscaaartsr rypslkgpam saaallqevl ggaprpsglg
      121 eaaapgktrs frprdfylrs saflrhqalk kppviasgfg tarpvvllpp peppvkrrar
      181 gvlessrhaa prrvfhlgre reqsqevapl agpcmakerk assvsaedgy meassgrrkv
      241 rirsnfvses gareareaag lgaqgeqesw ppsdareaaw qallpsrvip tsieeiiasl
      301 qseaqlasdq tikelirsvl gqnyditmed islmgkmylk tspmqaetpe iqaeykfqmg
      361 aeesqmsvhk elsetmssil qieqediewg pseaesivfk pqeisqvqpa eelskpledg
      421 qptsdskeak wvsltakspe flqiegkeik rmrkrkslrp rksskplcdk klhkkipqdy
      481 smphlhdlct tipaqelpvd lrlasrvyht anrkghdtll gkfgtsfldd rftdeeqtdr
      541 ilygipvmdd nqeyvhippt pqgippelaq gtrerahkph levlgeemya ypeftklfwn
      601 taapkfsvpe svmketlypk yesvqasrll tdklsykssv itlhqhsrtn fwcflprksa
      661 sfesiqkwfs aqptqlrrvk ssvdlrkeki iapleikndm qssikevmfq kakelkrqlq
      721 ltkqnkteep nyvkesiddi fdnmcekhsl rnlsltliea skkagisyiv ypkkkkmrwk
      781 krlkqqklif vheelskppk slersashgi lpgqkkylfk vplyerqirc pslplylnfe
      841 kfvqakggip enidprtwal drlieykdas ipvkekddki svpedpperv keppklklnd
      901 yvesdlpqev ikyyesevki lteeindktk ypafaycrrg aiyrklgklq samndlqrvi
      961 lleplflnay whrhliylfq dkinealddl nyihkynknn teaylskaei yrgkkditla
     1021 ilnytqaiks tptdadiyfr rgemyeitnk vlaiddfskc ifydpkrtda llkrglfyce
     1081 nenwfaaied ftallnidhq nsqartyrgi ayvkwkfyke atqdfsaaih ldpnnwlaly
     1141 yrgclfrksn pfralqdysv sepe
//
LOCUS       XP_047287292            1211 aa            linear   PRI 05-AUG-2025
DEFINITION  tetratricopeptide repeat protein 6 isoform X8 [Homo sapiens].
ACCESSION   XP_047287292
VERSION     XP_047287292.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431336.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1211
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1211
                     /product="tetratricopeptide repeat protein 6 isoform X8"
                     /calculated_mol_wt=140216
     Region          234..262
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          241..1133
                     /region_name="PEP_TPR_lipo"
                     /note="putative PEP-CTERM system TPR-repeat lipoprotein;
                     TIGR02917"
                     /db_xref="CDD:274350"
     Region          267..297
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          303..330
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          335..364
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(370,373..374,377..378,380,404,407..408,411..412,
                     414..415,438,441..442,445,448)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          370..397
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          402..432
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          474..500
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          508..535
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(510..511,514..515,518,542,545..546,549..550,
                     552..553,576,579..580,583..584,587)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          540..570
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          609..634
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          648..671
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          687..715
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          720..749
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          764..790
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(766..767,770..771,773,797,800..801,804..805,
                     807..808,831,834..835,838..839,842)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          795..825
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          830..853
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          869..895
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(871..872,875..876,878,902,905..906,909..910,
                     912..913,936,939..940,943..944,947)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          900..930
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          935..965
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          972..1000
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1005..1035
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1039..>1208
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          1039..1067
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1075..1101
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(1077..1078,1081..1082,1084,1108,1111..1112,
                     1115..1116,1118..1119,1142,1145..1146,1149..1150,1153)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          1106..1136
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1141..1169
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1175..1203
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..1211
                     /gene="TTC6"
                     /gene_synonym="C14orf25; NCRNA00291"
                     /coded_by="XM_047431336.1:315..3950"
                     /db_xref="GeneID:319089"
                     /db_xref="HGNC:HGNC:19739"
                     /db_xref="MIM:620954"
ORIGIN      
        1 mqssikevmf qkakelkrql qltkqnktee pnyvkesidd ifdnmcekhs lrnlsltlie
       61 askkagisyi vypkkkkmrw kkrlkqqkli fvheelskpp kslersashg ilpgqkkylf
      121 kvplyerqir cpslplylnf ekfvqakggi penidprtwa ldrlieykda sipvkekddk
      181 isvpedpper vkeppklkln dyvesdlpqe vikyyesevk ilteeindkt kypafaycrr
      241 gaiyrklgkl qsamndlqrv illeplflna ywhrhliylf qdkinealdd lnyihkynkn
      301 nteaylskae iyrgkkditl ailnytqaik stptdadiyf rrgemyeitn kvlaiddfsk
      361 cifydpkrtd allkrglfyc enenwfaaie dftallnidh qnsqartyrg iayvkwkfyk
      421 eatqdfsaai hldpnnwlal yyrgclfrks npfralqdys vsalindgye nlgcflhrgi
      481 vyahlklwll aicdfetvis lertitlayv niglihllhl dnyteaiwqf seairidplc
      541 iqsylcraet yfklhklkka vnelsraihl qpdgiqlyir rgqyllmmky ydlakftiyq
      601 iaemdkglse lspmqqaliy sfcenhdkai evldgiswnr aemtmcalla kvqmkakrtk
      661 eavevlkkal daishsdkgp dataisadcl ynlglcymee gnlqmafdsf tkavkanpdf
      721 aesfyqrglc kvklhkdssi ldfnraitln pkhyqemhtg glgaylsrva fyglkgrysk
      781 ailncnkaik iypesvrayl yrgvlkyynk tyklaitdlt taismdknsy tafynralcy
      841 tkirelqmal tdygivllld atetvklntf lnrgliyvel gqygfaledf kqaalisrtn
      901 gslchatamc hhrinefeea vnfftwalki npcfldayvg rgnsymeygh deatkqaqkd
      961 flkalhinpa yikarisfgy nlqaqgkfqk awnhftiaid tdpknylaye gravvclqmg
     1021 nnfaamqdin aamkisttae fltnrgvihe fmghkqnamk dyqdaitlnp kyslayfnag
     1081 niyfhhrqfs qasdyfskal kfdpeneyvl mnraitntil kkyeeakedf anviescpfw
     1141 aavyfnrahf yyclkqyela eedlnkalsl kpndalvynf rakvrgkigl ieeamadynq
     1201 aldledyasv i
//
LOCUS       XP_047287293            1054 aa            linear   PRI 05-AUG-2025
DEFINITION  tetratricopeptide repeat protein 6 isoform X9 [Homo sapiens].
ACCESSION   XP_047287293
VERSION     XP_047287293.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431337.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1054
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1054
                     /product="tetratricopeptide repeat protein 6 isoform X9"
                     /calculated_mol_wt=122685
     Region          <615..716
                     /region_name="BepA"
                     /note="Outer membrane protein chaperone/metalloprotease
                     BepA/YfgC, contains M48 and TPR domains [Cell
                     wall/membrane/envelope biogenesis, Posttranslational
                     modification, protein turnover, chaperones]; COG4783"
                     /db_xref="CDD:443813"
     Region          615..643
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          648..678
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          677..>840
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          684..711
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          716..745
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(751,754..755,758..759,761,785,788..789,792..793,
                     795..796,819,822..823,826,829)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          751..778
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          777..1010
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          783..813
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          855..881
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          889..916
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(891..892,895..896,899,923,926..927,930..931,
                     933..934,957,960..961,964..965,968)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          921..951
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          990..1015
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..1054
                     /gene="TTC6"
                     /gene_synonym="C14orf25; NCRNA00291"
                     /coded_by="XM_047431337.1:428..3592"
                     /db_xref="GeneID:319089"
                     /db_xref="HGNC:HGNC:19739"
                     /db_xref="MIM:620954"
ORIGIN      
        1 mrrgtrihgs edislmgkmy lktspmqaet peiqaeykfq mgaeesqmsv hkelsetmss
       61 ilqieqedie wgpseaesiv fkpqeisqvq paeelskple dgqptsdske akwvsltaks
      121 peflqiegke ikrmrkrksl rprksskplc dkklhkkipq dysmphlhdl cttipaqelp
      181 vdlrlasrvy htanrkghdt llgkfgtsfl ddrftdeeqt drilygipvm ddnqeyvhip
      241 ptpqgippel aqgtrerahk phlevlgeem yaypeftklf wntaapkfsv pesvmketly
      301 pkyesvqasr lltdklsyks svitlhqhsr tnfwcflprk sasfesiqkw fsaqptqlrr
      361 vkssvdlrke kiiapleikn dmqssikevm fqkakelkrq lqltkqnkte epnyvkesid
      421 difdnmcekh slrnlsltli easkkagisy ivypkkkkmr wkkrlkqqkl ifvheelskp
      481 pkslersash gilpgqkkyl fkvplyerqi rcpslplyln fekfvqakgg ipenidprtw
      541 aldrlieykd asipvkekdd kisvpedppe rvkeppklkl ndyvesdlpq evikyyesev
      601 kilteeindk tkypafaycr rgaiyrklgk lqsamndlqr villeplfln aywhrhliyl
      661 fqdkineald dlnyihkynk nnteaylska eiyrgkkdit lailnytqai kstptdadiy
      721 frrgemyeit nkvlaiddfs kcifydpkrt dallkrglfy cenenwfaai edftallnid
      781 hqnsqartyr giayvkwkfy keatqdfsaa ihldpnnwla lyyrgclfrk snpfralqdy
      841 svsalindgy enlgcflhrg ivyahlklwl laicdfetvi slertitlay vniglihllh
      901 ldnyteaiwq fseairidpl ciqsylcrae tyfklhklkk avnelsraih lqpdgiqlyi
      961 rrgqyllmmk yydlakftiy qiaemdkgls elspmqqali ysfcenhdka ievldgiswn
     1021 raemtmcall akvqmkakrt kgrgwswkpl ssan
//
LOCUS       XP_016876746            1027 aa            linear   PRI 05-AUG-2025
DEFINITION  tetratricopeptide repeat protein 6 isoform X10 [Homo sapiens].
ACCESSION   XP_016876746
VERSION     XP_016876746.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021257.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1027
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1027
                     /product="tetratricopeptide repeat protein 6 isoform X10"
                     /calculated_mol_wt=117392
     Site            order(899..900,902,934,937..938,941..942,944..945,968,
                     971..972,975..976,979)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          <901..>1000
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          924..962
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          967..991
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..1027
                     /gene="TTC6"
                     /gene_synonym="C14orf25; NCRNA00291"
                     /coded_by="XM_017021257.2:428..3511"
                     /db_xref="GeneID:319089"
                     /db_xref="HGNC:HGNC:19739"
                     /db_xref="MIM:620954"
ORIGIN      
        1 mrrgtrihgs evkfvkmsti prhfglkyke esymfkelek vrqetkkdfl rfkqklaskp
       61 avdespvhsl hapgparpar vscaaartsr rypslkgpam saaallqevl ggaprpsglg
      121 eaaapgktrs frprdfylrs saflrhqalk kppviasgfg tarpvvllpp peppvkrrar
      181 gvlessrhaa prrvfhlgre reqsqevapl agpcmakerk assvsaedgy meassgrrkv
      241 rirsnfvses gareareaag lgaqgeqesw ppsdareaaw qallpsrvip tsieeiiasl
      301 qseaqlasdq tikelirsvl gqnyditmed islmgkmylk tspmqaetpe iqaeykfqmg
      361 aeesqmsvhk elsetmssil qieqediewg pseaesivfk pqeisqvqpa eelskpledg
      421 qptsdskeak wvsltakspe flqiegkeik rmrkrkslrp rksskplcdk klhkkipqdy
      481 smphlhdlct tipaqelpvd lrlasrvyht anrkghdtll gkfgtsfldd rftdeeqtdr
      541 ilygipvmdd nqeyvhippt pqgippelaq gtrerahkph levlgeemya ypeftklfwn
      601 taapkfsvpe svmketlypk yesvqasrll tdklsykssv itlhqhsrtn fwcflprksa
      661 sfesiqkwfs aqptqlrrvk ssvdlrkeki iapleikndm qssikevmfq kakelkrqlq
      721 ltkqnkteep nyvkesiddi fdnmcekhsl rnlsltliea skkagisyiv ypkkkkmrwk
      781 krlkqqklif vheelskppk slersashgi lpgqkkylfk vplyerqirc pslplylnfe
      841 kfvqakggip enidprtwal drlieykdas ipvkekddki svpedpperv keppklklnd
      901 yvesdlpqev ikyyesevki lteeindktk ypafaycrrg aiyrklgklq samndlqrvi
      961 lleplflnay whrhliylfq dkinealddl nyihkynknn tghteglhml ngnfikkqlk
     1021 ifllqft
//
LOCUS       XP_047287295             417 aa            linear   PRI 05-AUG-2025
DEFINITION  serpin A9 isoform X1 [Homo sapiens].
ACCESSION   XP_047287295
VERSION     XP_047287295.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431339.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..417
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..417
                     /product="serpin A9 isoform X1"
                     /calculated_mol_wt=46426
     Region          30..417
                     /region_name="serpinA9_centerin"
                     /note="serpin family A member 9, centerin; cd19556"
                     /db_xref="CDD:381024"
     Site            order(361..385,387..392)
                     /site_type="other"
                     /note="reactive center loop (RCL)"
                     /db_xref="CDD:381024"
     CDS             1..417
                     /gene="SERPINA9"
                     /gene_synonym="GCET1; SERPINA11; SERPINA11b"
                     /coded_by="XM_047431339.1:1267..2520"
                     /db_xref="GeneID:327657"
                     /db_xref="HGNC:HGNC:15995"
                     /db_xref="MIM:615677"
ORIGIN      
        1 masylygvlf avglcapiyc vspanapsay prpsstkstp asqvyslntd fafrlyrrlv
       61 letpsqniff spvsvstsla mlslgahsvt ktqilqglgf nlthtpesai hqgfqhlvhs
      121 ltvpskdltl kmgsalfvkk elqlqanflg nvkrlyeaev fstdfsnpsi aqarinshvk
      181 kktqgkvvdi iqgldlltam vlvnhiffka kwekpfhpey trknfpflvg eqvtvhvpmm
      241 hqkeqfafgv dtelncfvlq mdykgdavaf fvlpskgkmr qleqalsart lrkwshslqk
      301 rwievfiprf sisasynlet ilpkmgiqnv fdknadfsgi akrdslqvsk athkavldvs
      361 eegteataat ttkfivrskd gpsyftvsfn rtflmmitnk atdgilflgk venptks
//
LOCUS       XP_011535016             417 aa            linear   PRI 05-AUG-2025
DEFINITION  serpin A9 isoform X1 [Homo sapiens].
ACCESSION   XP_011535016
VERSION     XP_011535016.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536714.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..417
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..417
                     /product="serpin A9 isoform X1"
                     /calculated_mol_wt=46426
     Region          30..417
                     /region_name="serpinA9_centerin"
                     /note="serpin family A member 9, centerin; cd19556"
                     /db_xref="CDD:381024"
     Site            order(361..385,387..392)
                     /site_type="other"
                     /note="reactive center loop (RCL)"
                     /db_xref="CDD:381024"
     CDS             1..417
                     /gene="SERPINA9"
                     /gene_synonym="GCET1; SERPINA11; SERPINA11b"
                     /coded_by="XM_011536714.3:292..1545"
                     /db_xref="GeneID:327657"
                     /db_xref="HGNC:HGNC:15995"
                     /db_xref="MIM:615677"
ORIGIN      
        1 masylygvlf avglcapiyc vspanapsay prpsstkstp asqvyslntd fafrlyrrlv
       61 letpsqniff spvsvstsla mlslgahsvt ktqilqglgf nlthtpesai hqgfqhlvhs
      121 ltvpskdltl kmgsalfvkk elqlqanflg nvkrlyeaev fstdfsnpsi aqarinshvk
      181 kktqgkvvdi iqgldlltam vlvnhiffka kwekpfhpey trknfpflvg eqvtvhvpmm
      241 hqkeqfafgv dtelncfvlq mdykgdavaf fvlpskgkmr qleqalsart lrkwshslqk
      301 rwievfiprf sisasynlet ilpkmgiqnv fdknadfsgi akrdslqvsk athkavldvs
      361 eegteataat ttkfivrskd gpsyftvsfn rtflmmitnk atdgilflgk venptks
//
LOCUS       XP_011535017             417 aa            linear   PRI 05-AUG-2025
DEFINITION  serpin A9 isoform X1 [Homo sapiens].
ACCESSION   XP_011535017
VERSION     XP_011535017.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536715.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..417
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..417
                     /product="serpin A9 isoform X1"
                     /calculated_mol_wt=46426
     Region          30..417
                     /region_name="serpinA9_centerin"
                     /note="serpin family A member 9, centerin; cd19556"
                     /db_xref="CDD:381024"
     Site            order(361..385,387..392)
                     /site_type="other"
                     /note="reactive center loop (RCL)"
                     /db_xref="CDD:381024"
     CDS             1..417
                     /gene="SERPINA9"
                     /gene_synonym="GCET1; SERPINA11; SERPINA11b"
                     /coded_by="XM_011536715.3:178..1431"
                     /db_xref="GeneID:327657"
                     /db_xref="HGNC:HGNC:15995"
                     /db_xref="MIM:615677"
ORIGIN      
        1 masylygvlf avglcapiyc vspanapsay prpsstkstp asqvyslntd fafrlyrrlv
       61 letpsqniff spvsvstsla mlslgahsvt ktqilqglgf nlthtpesai hqgfqhlvhs
      121 ltvpskdltl kmgsalfvkk elqlqanflg nvkrlyeaev fstdfsnpsi aqarinshvk
      181 kktqgkvvdi iqgldlltam vlvnhiffka kwekpfhpey trknfpflvg eqvtvhvpmm
      241 hqkeqfafgv dtelncfvlq mdykgdavaf fvlpskgkmr qleqalsart lrkwshslqk
      301 rwievfiprf sisasynlet ilpkmgiqnv fdknadfsgi akrdslqvsk athkavldvs
      361 eegteataat ttkfivrskd gpsyftvsfn rtflmmitnk atdgilflgk venptks
//
LOCUS       XP_011535018             337 aa            linear   PRI 05-AUG-2025
DEFINITION  serpin A9 isoform X2 [Homo sapiens].
ACCESSION   XP_011535018
VERSION     XP_011535018.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536716.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..337
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..337
                     /product="serpin A9 isoform X2"
                     /calculated_mol_wt=37784
     Region          1..337
                     /region_name="serpin"
                     /note="SERine Proteinase INhibitors (serpin) family;
                     cl38926"
                     /db_xref="CDD:476815"
     Site            order(283..293,312)
                     /site_type="other"
                     /note="reactive center loop (RCL)"
                     /db_xref="CDD:381024"
     CDS             1..337
                     /gene="SERPINA9"
                     /gene_synonym="GCET1; SERPINA11; SERPINA11b"
                     /coded_by="XM_011536716.3:342..1355"
                     /db_xref="GeneID:327657"
                     /db_xref="HGNC:HGNC:15995"
                     /db_xref="MIM:615677"
ORIGIN      
        1 mlslgahsvt ktqilqglgf nlthtpesai hqgfqhlvhs ltvpskdltl kmgsalfvkk
       61 elqlqanflg nvkrlyeaev fstdfsnpsi aqarinshvk kktqgkvvdi iqgldlltam
      121 vlvnhiffka kwekpfhpey trknfpflvg eqvtvhvpmm hqkeqfafgv dtelncfvlq
      181 mdykgdavaf fvlpskgkmr qleqalsart lrkwshslqk rwievfiprf sisasynlet
      241 ilpkmgiqnv fdknadfsgi akrdslqvsk athkavldvs eegteataat ttkfivrskd
      301 gpsyftvsfn rtflmmitnk atdgilflgk venptks
//
LOCUS       XP_047287297             337 aa            linear   PRI 05-AUG-2025
DEFINITION  serpin A9 isoform X2 [Homo sapiens].
ACCESSION   XP_047287297
VERSION     XP_047287297.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431341.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..337
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..337
                     /product="serpin A9 isoform X2"
                     /calculated_mol_wt=37784
     Region          1..337
                     /region_name="serpin"
                     /note="SERine Proteinase INhibitors (serpin) family;
                     cl38926"
                     /db_xref="CDD:476815"
     Site            order(283..293,312)
                     /site_type="other"
                     /note="reactive center loop (RCL)"
                     /db_xref="CDD:381024"
     CDS             1..337
                     /gene="SERPINA9"
                     /gene_synonym="GCET1; SERPINA11; SERPINA11b"
                     /coded_by="XM_047431341.1:1317..2330"
                     /db_xref="GeneID:327657"
                     /db_xref="HGNC:HGNC:15995"
                     /db_xref="MIM:615677"
ORIGIN      
        1 mlslgahsvt ktqilqglgf nlthtpesai hqgfqhlvhs ltvpskdltl kmgsalfvkk
       61 elqlqanflg nvkrlyeaev fstdfsnpsi aqarinshvk kktqgkvvdi iqgldlltam
      121 vlvnhiffka kwekpfhpey trknfpflvg eqvtvhvpmm hqkeqfafgv dtelncfvlq
      181 mdykgdavaf fvlpskgkmr qleqalsart lrkwshslqk rwievfiprf sisasynlet
      241 ilpkmgiqnv fdknadfsgi akrdslqvsk athkavldvs eegteataat ttkfivrskd
      301 gpsyftvsfn rtflmmitnk atdgilflgk venptks
//
LOCUS       XP_011535020             853 aa            linear   PRI 05-AUG-2025
DEFINITION  heat shock protein HSP 90-alpha isoform X1 [Homo sapiens].
ACCESSION   XP_011535020
VERSION     XP_011535020.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536718.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..853
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..853
                     /product="heat shock protein HSP 90-alpha isoform X1"
                     /calculated_mol_wt=97943
     Region          139..853
                     /region_name="HSP90"
                     /note="Hsp90 protein; cl46693"
                     /db_xref="CDD:481033"
     CDS             1..853
                     /gene="HSP90AA1"
                     /gene_synonym="EL52; HEL-S-65p; Hsp103; HSP86; Hsp89;
                     HSP89A; Hsp90; HSP90A; HSP90N; HSPC1; HSPCA; HSPCAL1;
                     HSPCAL4; HSPN; LAP-2; LAP2"
                     /coded_by="XM_011536718.3:346..2907"
                     /db_xref="GeneID:3320"
                     /db_xref="HGNC:HGNC:5253"
                     /db_xref="MIM:140571"
ORIGIN      
        1 mppcsggdgs tppgpslrdr dcpaqsaeyp rdrldprpgs pseassppfl rrapvnwyqe
       61 kaqvflwhlm vsgsttllcl wkqpfhvsaf pvtaslafrq sqgagqhlyk dlqpfillrl
      121 lmpeetqtqd qpmeeeevet fafqaeiaql msliintfys nkeiflreli snssdaldki
      181 ryesltdpsk ldsgkelhin lipnkqdrtl tivdtgigmt kadlinnlgt iaksgtkafm
      241 ealqagadis migqfgvgfy saylvaekvt vitkhnddeq yawessaggs ftvrtdtgep
      301 mgrgtkvilh lkedqteyle errikeivkk hsqfigypit lfvekerdke vsddeaeeke
      361 dkeeekekee kesedkpeie dvgsdeeeek kdgdkkkkkk ikekyidqee lnktkpiwtr
      421 npdditneey gefyksltnd wedhlavkhf svegqlefra llfvprrapf dlfenrkkkn
      481 niklyvrrvf imdnceelip eylnfirgvv dsedlplnis remlqqskil kvirknlvkk
      541 clelftelae dkenykkfye qfskniklgi hedsqnrkkl sellryytsa sgdemvslkd
      601 yctrmkenqk hiyyitgetk dqvansafve rlrkhglevi ymiepideyc vqqlkefegk
      661 tlvsvtkegl elpedeeekk kqeekktkfe nlckimkdil ekkvekvvvs nrlvtspcci
      721 vtstygwtan merimkaqal rdnstmgyma akkhleinpd hsiietlrqk aeadkndksv
      781 kdlvillyet allssgfsle dpqthanriy rmiklglgid eddptaddts aavteemppl
      841 egdddtsrme evd
//
LOCUS       XP_011535022             532 aa            linear   PRI 05-AUG-2025
DEFINITION  solute carrier family 35 member F4 isoform X1 [Homo sapiens].
ACCESSION   XP_011535022
VERSION     XP_011535022.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536720.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..532
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..532
                     /product="solute carrier family 35 member F4 isoform X1"
                     /calculated_mol_wt=59194
     Region          <285..485
                     /region_name="RhaT"
                     /note="Permease of the drug/metabolite transporter (DMT)
                     superfamily [Carbohydrate transport and metabolism, Amino
                     acid transport and metabolism, General function prediction
                     only]; COG0697"
                     /db_xref="CDD:440461"
     CDS             1..532
                     /gene="SLC35F4"
                     /gene_synonym="C14orf36; c14_5373"
                     /coded_by="XM_011536720.4:1288..2886"
                     /db_xref="GeneID:341880"
                     /db_xref="HGNC:HGNC:19845"
ORIGIN      
        1 mlvhlrdsly pqlginqlsy trklatrcss vvtasytvlk pekrkillqy kfqketfqlp
       61 fkttfwinnf qivifplgsl cstsrssvtr ckpgancpss hsgisrqlsp lsvtedssap
      121 ilelqnqgss gvcghrverq nrsaddgtqt hsenssqenr ikarclscts mvlkgiwgll
      181 iilsvssswv gttqivkity knfycpffmt wfstnwnimf fpvyysghla taqekqspmk
      241 kfrecsrifg edgltlklfl krtapfsilw tltnylylla lkkltatdvs alfccnkafv
      301 fllswivlkd rfmgvrivaa imaitgivmm ayadnfhads iigvafavgs astsalykvl
      361 fkmflgsanf geaahfvstl gffnlifisf tpvilyftkv ehwssfaalp wgclcgmagl
      421 wlafnilvnv gvvltypili sigtvlsvpg naavdllkqe vifnvvrlaa tiiicigfll
      481 mllpeewdei tlrfinslke kkseehvddv tdpsihlrgr grangtvsip la
//
LOCUS       XP_011535023             531 aa            linear   PRI 05-AUG-2025
DEFINITION  solute carrier family 35 member F4 isoform X2 [Homo sapiens].
ACCESSION   XP_011535023
VERSION     XP_011535023.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536721.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..531
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..531
                     /product="solute carrier family 35 member F4 isoform X2"
                     /calculated_mol_wt=59123
     Region          <284..484
                     /region_name="RhaT"
                     /note="Permease of the drug/metabolite transporter (DMT)
                     superfamily [Carbohydrate transport and metabolism, Amino
                     acid transport and metabolism, General function prediction
                     only]; COG0697"
                     /db_xref="CDD:440461"
     CDS             1..531
                     /gene="SLC35F4"
                     /gene_synonym="C14orf36; c14_5373"
                     /coded_by="XM_011536721.4:1288..2883"
                     /db_xref="GeneID:341880"
                     /db_xref="HGNC:HGNC:19845"
ORIGIN      
        1 mlvhlrdsly pqlginqlsy trklatrcss vvtasytvlk pekrkillqy kfqketfqlp
       61 fkttfwinnf qivifplgsl cstsrssvtr ckpgancpss hsgisrqlsp lsvtedssap
      121 ilelqnqgss gvcghrverq nrsddgtqth senssqenri karclsctsm vlkgiwglli
      181 ilsvssswvg ttqivkityk nfycpffmtw fstnwnimff pvyysghlat aqekqspmkk
      241 frecsrifge dgltlklflk rtapfsilwt ltnylyllal kkltatdvsa lfccnkafvf
      301 llswivlkdr fmgvrivaai maitgivmma yadnfhadsi igvafavgsa stsalykvlf
      361 kmflgsanfg eaahfvstlg ffnlifisft pvilyftkve hwssfaalpw gclcgmaglw
      421 lafnilvnvg vvltypilis igtvlsvpgn aavdllkqev ifnvvrlaat iiicigfllm
      481 llpeewdeit lrfinslkek kseehvddvt dpsihlrgrg rangtvsipl a
//
LOCUS       XP_011535025             472 aa            linear   PRI 05-AUG-2025
DEFINITION  solute carrier family 35 member F4 isoform X3 [Homo sapiens].
ACCESSION   XP_011535025
VERSION     XP_011535025.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536723.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..472
                     /product="solute carrier family 35 member F4 isoform X3"
                     /calculated_mol_wt=52291
     Region          <225..425
                     /region_name="RhaT"
                     /note="Permease of the drug/metabolite transporter (DMT)
                     superfamily [Carbohydrate transport and metabolism, Amino
                     acid transport and metabolism, General function prediction
                     only]; COG0697"
                     /db_xref="CDD:440461"
     CDS             1..472
                     /gene="SLC35F4"
                     /gene_synonym="C14orf36; c14_5373"
                     /coded_by="XM_011536723.4:1206..2624"
                     /db_xref="GeneID:341880"
                     /db_xref="HGNC:HGNC:19845"
ORIGIN      
        1 mqqktvcelq ktwqletlkn fctsrssvtr ckpgancpss hsgisrqlsp lsvtedssap
       61 ilelqnqgss gvcghrverq nrsaddgtqt hsenssqenr ikarclscts mvlkgiwgll
      121 iilsvssswv gttqivkity knfycpffmt wfstnwnimf fpvyysghla taqekqspmk
      181 kfrecsrifg edgltlklfl krtapfsilw tltnylylla lkkltatdvs alfccnkafv
      241 fllswivlkd rfmgvrivaa imaitgivmm ayadnfhads iigvafavgs astsalykvl
      301 fkmflgsanf geaahfvstl gffnlifisf tpvilyftkv ehwssfaalp wgclcgmagl
      361 wlafnilvnv gvvltypili sigtvlsvpg naavdllkqe vifnvvrlaa tiiicigfll
      421 mllpeewdei tlrfinslke kkseehvddv tdpsihlrgr grangtvsip la
//
LOCUS       XP_011535026             467 aa            linear   PRI 05-AUG-2025
DEFINITION  solute carrier family 35 member F4 isoform X4 [Homo sapiens].
ACCESSION   XP_011535026
VERSION     XP_011535026.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536724.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..467
                     /product="solute carrier family 35 member F4 isoform X4"
                     /calculated_mol_wt=51464
     Region          <220..420
                     /region_name="RhaT"
                     /note="Permease of the drug/metabolite transporter (DMT)
                     superfamily [Carbohydrate transport and metabolism, Amino
                     acid transport and metabolism, General function prediction
                     only]; COG0697"
                     /db_xref="CDD:440461"
     CDS             1..467
                     /gene="SLC35F4"
                     /gene_synonym="C14orf36; c14_5373"
                     /coded_by="XM_011536724.4:974..2377"
                     /db_xref="GeneID:341880"
                     /db_xref="HGNC:HGNC:19845"
ORIGIN      
        1 myrrichlag npgartgtsr ssvtrckpga ncpsshsgis rqlsplsvte dssapilelq
       61 nqgssgvcgh rverqnrsad dgtqthsens sqenrikarc lsctsmvlkg iwglliilsv
      121 ssswvgttqi vkityknfyc pffmtwfstn wnimffpvyy sghlataqek qspmkkfrec
      181 srifgedglt lklflkrtap fsilwtltny lyllalkklt atdvsalfcc nkafvfllsw
      241 ivlkdrfmgv rivaaimait givmmayadn fhadsiigva favgsastsa lykvlfkmfl
      301 gsanfgeaah fvstlgffnl ifisftpvil yftkvehwss faalpwgclc gmaglwlafn
      361 ilvnvgvvlt ypilisigtv lsvpgnaavd llkqevifnv vrlaatiiic igfllmllpe
      421 ewdeitlrfi nslkekksee hvddvtdpsi hlrgrgrang tvsipla
//
LOCUS       XP_047287299             227 aa            linear   PRI 05-AUG-2025
DEFINITION  solute carrier family 35 member F4 isoform X5 [Homo sapiens].
ACCESSION   XP_047287299
VERSION     XP_047287299.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431343.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..227
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..227
                     /product="solute carrier family 35 member F4 isoform X5"
                     /calculated_mol_wt=24499
     CDS             1..227
                     /gene="SLC35F4"
                     /gene_synonym="C14orf36; c14_5373"
                     /coded_by="XM_047431343.1:3270..3953"
                     /db_xref="GeneID:341880"
                     /db_xref="HGNC:HGNC:19845"
ORIGIN      
        1 mdcaerqvhg sevaaimait givmmayadn fhadsiigva favgsastsa lykvlfkmfl
       61 gsanfgeaah fvstlgffnl ifisftpvil yftkvehwss faalpwgclc gmaglwlafn
      121 ilvnvgvvlt ypilisigtv lsvpgnaavd llkqevifnv vrlaatiiic igfllmllpe
      181 ewdeitlrfi nslkekksee hvddvtdpsi hlrgrgrang tvsipla
//
LOCUS       XP_024305329             211 aa            linear   PRI 05-AUG-2025
DEFINITION  solute carrier family 35 member F4 isoform X6 [Homo sapiens].
ACCESSION   XP_024305329
VERSION     XP_024305329.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449561.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..211
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..211
                     /product="solute carrier family 35 member F4 isoform X6"
                     /calculated_mol_wt=22801
     CDS             1..211
                     /gene="SLC35F4"
                     /gene_synonym="C14orf36; c14_5373"
                     /coded_by="XM_024449561.2:206..841"
                     /db_xref="GeneID:341880"
                     /db_xref="HGNC:HGNC:19845"
ORIGIN      
        1 maitgivmma yadnfhadsi igvafavgsa stsalykvlf kmflgsanfg eaahfvstlg
       61 ffnlifisft pvilyftkve hwssfaalpw gclcgmaglw lafnilvnvg vvltypilis
      121 igtvlsvpgn aavdllkqev ifnvvrlaat iiicigfllm llpeewdeit lrfinslkek
      181 kseehvddvt dpsihlrgrg rangtvsipl a
//
LOCUS       XP_024305331            1494 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 9 isoform X1 [Homo sapiens].
ACCESSION   XP_024305331
VERSION     XP_024305331.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449563.2
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 37% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1494
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1494
                     /product="leucine-rich repeat-containing protein 9 isoform
                     X1"
                     /calculated_mol_wt=171339
     Region          37..51
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          55..236
                     /region_name="PPP1R42"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     cl42388"
                     /db_xref="CDD:455733"
     Region          56..77
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          78..99
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          100..121
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          122..143
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          144..166
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          192..223
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          631..1016
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          698..717
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          718..739
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          740..761
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          762..788
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          789..846
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          847..910
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          878..1066
                     /region_name="PPP1R42"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     cl42388"
                     /db_xref="CDD:455733"
     Region          911..932
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          933..954
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          955..978
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1026..1094
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1116..1361
                     /region_name="PPP1R42"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     cl42388"
                     /db_xref="CDD:455733"
     Region          1141..1166
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1167..1203
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1204..1227
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1228..1249
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1250..1273
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1274..1295
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1296..1320
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     CDS             1..1494
                     /gene="LRRC9"
                     /coded_by="XM_024449563.2:119..4603"
                     /db_xref="GeneID:341883"
                     /db_xref="HGNC:HGNC:19848"
ORIGIN      
        1 miesenlnqe eiikelclcn glsyemvgqe gsdtsklemf flgyprivgl slfpnltslt
       61 ivaqdikeis glepclqlke lwiaecciek ieglqecrnl eklylyfnki skienlekli
      121 klkvlwlnhn tiknieglqt lknlkdlnla gnlinsigrc ldsneqlerl nlsgnqicsf
      181 keltnltrlp clkdlclndp qyttnpvcll cnysthvlyh lpclqrfdtl dvsakqikel
      241 adttamkkim yynmriktlq rhlkedlekl ndqkcklqkl peervklfsf vkktlerela
      301 elkgsgkghs dgsnnskvtd petlkscetv teepslqqki laklnalner vtfwnkklde
      361 ieaiyhievk qkkkshglli plllieletv gnfhfeegtr sddwfnfcye lilsrfcawd
      421 frtygitgvk vkriikvnnr ilrlkfeekf qkflenedmh dsesyrrmle clfyvfdpev
      481 svkkkhllqi lekgfkdset sklplkkeai ivsnslsise cprieflqqk hkdekkislk
      541 helfrhgill itkvflgqsv qahekesisq snypmvnsvf iprkyllnsv mgqrncdcsv
      601 rqckwfvfdh dlvlpeyvve feyitmvkap slfsvfnnvi leeskknpev svfskdlkfd
      661 devikmepri karpklisld dktilslakt svyshivsln lhgnslsklr dlskltglrk
      721 lnisfneftc lddvyhlynl eyldashnhv itlegfrglm klkhldlswn qlkksgnein
      781 mlckhttsll tldiqhnpwq kpatlrlsvi grlktlthln gvfiseeeat aamkfiagtr
      841 itqlsllrhs stkeerpril siwpsakilt qvsklgphlh lsgncylkit alnldgqhlf
      901 eitnleklen lkwasfsnnn ltkmeglesc inleeltldg nciskiegis kmtkltrlsi
      961 nnnlltgwee htfdnmlhlh slslennrit slsglqksft lvelyisnny iavnqemhnl
     1021 kglcnlvild mcgniiiwnq enyrlfvifh lpelkaldgi piepsetdsa kdlfggrlts
     1081 dmiaerqghs nfkqmqelnw tsssirtvdl ipvdqfrnvc nvnlqnnhlt sfsgliylpn
     1141 vkvlclnynh iesimprlkp qthltsrqll yqkvpssgyg qqgisktnrd imssenlppi
     1201 mhslevlhlg yngicnliql qlnrlrnlkf lflqgneisq vegldnlvvl qelvvdhnri
     1261 rsfndsafak pssllalhle enrlrelgkl qslvkleklf lgynkiqdit elekldvist
     1321 lreltvygnp icrkmlhrhm lifrlpnlqm ldgspvnsdd rakaefhlae lqakknslip
     1381 vthspmdgrs fgqvktppie itnvllpsgf shylgsdvtl tpevedkknk nagiltnnpr
     1441 sihaeiafrq lrgisispsl lshqniaspt aqiyqsnqdk rrifgsnfpr snrm
//
LOCUS       XP_024305332            1494 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 9 isoform X1 [Homo sapiens].
ACCESSION   XP_024305332
VERSION     XP_024305332.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449564.2
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 37% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1494
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1494
                     /product="leucine-rich repeat-containing protein 9 isoform
                     X1"
                     /calculated_mol_wt=171339
     Region          37..51
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          55..236
                     /region_name="PPP1R42"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     cl42388"
                     /db_xref="CDD:455733"
     Region          56..77
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          78..99
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          100..121
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          122..143
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          144..166
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          192..223
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          631..1016
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          698..717
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          718..739
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          740..761
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          762..788
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          789..846
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          847..910
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          878..1066
                     /region_name="PPP1R42"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     cl42388"
                     /db_xref="CDD:455733"
     Region          911..932
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          933..954
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          955..978
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1026..1094
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1116..1361
                     /region_name="PPP1R42"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     cl42388"
                     /db_xref="CDD:455733"
     Region          1141..1166
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1167..1203
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1204..1227
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1228..1249
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1250..1273
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1274..1295
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1296..1320
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     CDS             1..1494
                     /gene="LRRC9"
                     /coded_by="XM_024449564.2:3782..8266"
                     /db_xref="GeneID:341883"
                     /db_xref="HGNC:HGNC:19848"
ORIGIN      
        1 miesenlnqe eiikelclcn glsyemvgqe gsdtsklemf flgyprivgl slfpnltslt
       61 ivaqdikeis glepclqlke lwiaecciek ieglqecrnl eklylyfnki skienlekli
      121 klkvlwlnhn tiknieglqt lknlkdlnla gnlinsigrc ldsneqlerl nlsgnqicsf
      181 keltnltrlp clkdlclndp qyttnpvcll cnysthvlyh lpclqrfdtl dvsakqikel
      241 adttamkkim yynmriktlq rhlkedlekl ndqkcklqkl peervklfsf vkktlerela
      301 elkgsgkghs dgsnnskvtd petlkscetv teepslqqki laklnalner vtfwnkklde
      361 ieaiyhievk qkkkshglli plllieletv gnfhfeegtr sddwfnfcye lilsrfcawd
      421 frtygitgvk vkriikvnnr ilrlkfeekf qkflenedmh dsesyrrmle clfyvfdpev
      481 svkkkhllqi lekgfkdset sklplkkeai ivsnslsise cprieflqqk hkdekkislk
      541 helfrhgill itkvflgqsv qahekesisq snypmvnsvf iprkyllnsv mgqrncdcsv
      601 rqckwfvfdh dlvlpeyvve feyitmvkap slfsvfnnvi leeskknpev svfskdlkfd
      661 devikmepri karpklisld dktilslakt svyshivsln lhgnslsklr dlskltglrk
      721 lnisfneftc lddvyhlynl eyldashnhv itlegfrglm klkhldlswn qlkksgnein
      781 mlckhttsll tldiqhnpwq kpatlrlsvi grlktlthln gvfiseeeat aamkfiagtr
      841 itqlsllrhs stkeerpril siwpsakilt qvsklgphlh lsgncylkit alnldgqhlf
      901 eitnleklen lkwasfsnnn ltkmeglesc inleeltldg nciskiegis kmtkltrlsi
      961 nnnlltgwee htfdnmlhlh slslennrit slsglqksft lvelyisnny iavnqemhnl
     1021 kglcnlvild mcgniiiwnq enyrlfvifh lpelkaldgi piepsetdsa kdlfggrlts
     1081 dmiaerqghs nfkqmqelnw tsssirtvdl ipvdqfrnvc nvnlqnnhlt sfsgliylpn
     1141 vkvlclnynh iesimprlkp qthltsrqll yqkvpssgyg qqgisktnrd imssenlppi
     1201 mhslevlhlg yngicnliql qlnrlrnlkf lflqgneisq vegldnlvvl qelvvdhnri
     1261 rsfndsafak pssllalhle enrlrelgkl qslvkleklf lgynkiqdit elekldvist
     1321 lreltvygnp icrkmlhrhm lifrlpnlqm ldgspvnsdd rakaefhlae lqakknslip
     1381 vthspmdgrs fgqvktppie itnvllpsgf shylgsdvtl tpevedkknk nagiltnnpr
     1441 sihaeiafrq lrgisispsl lshqniaspt aqiyqsnqdk rrifgsnfpr snrm
//
LOCUS       XP_024305333            1494 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 9 isoform X1 [Homo sapiens].
ACCESSION   XP_024305333
VERSION     XP_024305333.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449565.2
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 37% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1494
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1494
                     /product="leucine-rich repeat-containing protein 9 isoform
                     X1"
                     /calculated_mol_wt=171339
     Region          37..51
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          55..236
                     /region_name="PPP1R42"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     cl42388"
                     /db_xref="CDD:455733"
     Region          56..77
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          78..99
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          100..121
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          122..143
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          144..166
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          192..223
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          631..1016
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          698..717
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          718..739
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          740..761
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          762..788
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          789..846
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          847..910
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          878..1066
                     /region_name="PPP1R42"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     cl42388"
                     /db_xref="CDD:455733"
     Region          911..932
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          933..954
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          955..978
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1026..1094
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1116..1361
                     /region_name="PPP1R42"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     cl42388"
                     /db_xref="CDD:455733"
     Region          1141..1166
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1167..1203
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1204..1227
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1228..1249
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1250..1273
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1274..1295
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1296..1320
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     CDS             1..1494
                     /gene="LRRC9"
                     /coded_by="XM_024449565.2:85..4569"
                     /db_xref="GeneID:341883"
                     /db_xref="HGNC:HGNC:19848"
ORIGIN      
        1 miesenlnqe eiikelclcn glsyemvgqe gsdtsklemf flgyprivgl slfpnltslt
       61 ivaqdikeis glepclqlke lwiaecciek ieglqecrnl eklylyfnki skienlekli
      121 klkvlwlnhn tiknieglqt lknlkdlnla gnlinsigrc ldsneqlerl nlsgnqicsf
      181 keltnltrlp clkdlclndp qyttnpvcll cnysthvlyh lpclqrfdtl dvsakqikel
      241 adttamkkim yynmriktlq rhlkedlekl ndqkcklqkl peervklfsf vkktlerela
      301 elkgsgkghs dgsnnskvtd petlkscetv teepslqqki laklnalner vtfwnkklde
      361 ieaiyhievk qkkkshglli plllieletv gnfhfeegtr sddwfnfcye lilsrfcawd
      421 frtygitgvk vkriikvnnr ilrlkfeekf qkflenedmh dsesyrrmle clfyvfdpev
      481 svkkkhllqi lekgfkdset sklplkkeai ivsnslsise cprieflqqk hkdekkislk
      541 helfrhgill itkvflgqsv qahekesisq snypmvnsvf iprkyllnsv mgqrncdcsv
      601 rqckwfvfdh dlvlpeyvve feyitmvkap slfsvfnnvi leeskknpev svfskdlkfd
      661 devikmepri karpklisld dktilslakt svyshivsln lhgnslsklr dlskltglrk
      721 lnisfneftc lddvyhlynl eyldashnhv itlegfrglm klkhldlswn qlkksgnein
      781 mlckhttsll tldiqhnpwq kpatlrlsvi grlktlthln gvfiseeeat aamkfiagtr
      841 itqlsllrhs stkeerpril siwpsakilt qvsklgphlh lsgncylkit alnldgqhlf
      901 eitnleklen lkwasfsnnn ltkmeglesc inleeltldg nciskiegis kmtkltrlsi
      961 nnnlltgwee htfdnmlhlh slslennrit slsglqksft lvelyisnny iavnqemhnl
     1021 kglcnlvild mcgniiiwnq enyrlfvifh lpelkaldgi piepsetdsa kdlfggrlts
     1081 dmiaerqghs nfkqmqelnw tsssirtvdl ipvdqfrnvc nvnlqnnhlt sfsgliylpn
     1141 vkvlclnynh iesimprlkp qthltsrqll yqkvpssgyg qqgisktnrd imssenlppi
     1201 mhslevlhlg yngicnliql qlnrlrnlkf lflqgneisq vegldnlvvl qelvvdhnri
     1261 rsfndsafak pssllalhle enrlrelgkl qslvkleklf lgynkiqdit elekldvist
     1321 lreltvygnp icrkmlhrhm lifrlpnlqm ldgspvnsdd rakaefhlae lqakknslip
     1381 vthspmdgrs fgqvktppie itnvllpsgf shylgsdvtl tpevedkknk nagiltnnpr
     1441 sihaeiafrq lrgisispsl lshqniaspt aqiyqsnqdk rrifgsnfpr snrm
//
LOCUS       XP_024305334            1475 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 9 isoform X2 [Homo sapiens].
ACCESSION   XP_024305334
VERSION     XP_024305334.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449566.2
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 38% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1475
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1475
                     /product="leucine-rich repeat-containing protein 9 isoform
                     X2"
                     /calculated_mol_wt=168937
     Region          37..51
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          55..236
                     /region_name="PPP1R42"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     cl42388"
                     /db_xref="CDD:455733"
     Region          56..77
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          78..99
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          100..121
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          122..143
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          144..166
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          192..223
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          631..1016
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          698..717
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          718..739
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          740..761
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          762..788
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          789..846
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          847..910
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          878..1066
                     /region_name="PPP1R42"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     cl42388"
                     /db_xref="CDD:455733"
     Region          911..932
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          933..954
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          955..978
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1001..1025
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1026..1118
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1116..1331
                     /region_name="PPP1R42"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     cl42388"
                     /db_xref="CDD:455733"
     Region          1121..1140
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1141..1166
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1167..1203
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1228..1249
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1250..1273
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1274..1295
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1296..1320
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     CDS             1..1475
                     /gene="LRRC9"
                     /coded_by="XM_024449566.2:205..4632"
                     /db_xref="GeneID:341883"
                     /db_xref="HGNC:HGNC:19848"
ORIGIN      
        1 miesenlnqe eiikelclcn glsyemvgqe gsdtsklemf flgyprivgl slfpnltslt
       61 ivaqdikeis glepclqlke lwiaecciek ieglqecrnl eklylyfnki skienlekli
      121 klkvlwlnhn tiknieglqt lknlkdlnla gnlinsigrc ldsneqlerl nlsgnqicsf
      181 keltnltrlp clkdlclndp qyttnpvcll cnysthvlyh lpclqrfdtl dvsakqikel
      241 adttamkkim yynmriktlq rhlkedlekl ndqkcklqkl peervklfsf vkktlerela
      301 elkgsgkghs dgsnnskvtd petlkscetv teepslqqki laklnalner vtfwnkklde
      361 ieaiyhievk qkkkshglli plllieletv gnfhfeegtr sddwfnfcye lilsrfcawd
      421 frtygitgvk vkriikvnnr ilrlkfeekf qkflenedmh dsesyrrmle clfyvfdpev
      481 svkkkhllqi lekgfkdset sklplkkeai ivsnslsise cprieflqqk hkdekkislk
      541 helfrhgill itkvflgqsv qahekesisq snypmvnsvf iprkyllnsv mgqrncdcsv
      601 rqckwfvfdh dlvlpeyvve feyitmvkap slfsvfnnvi leeskknpev svfskdlkfd
      661 devikmepri karpklisld dktilslakt svyshivsln lhgnslsklr dlskltglrk
      721 lnisfneftc lddvyhlynl eyldashnhv itlegfrglm klkhldlswn qlkksgnein
      781 mlckhttsll tldiqhnpwq kpatlrlsvi grlktlthln gvfiseeeat aamkfiagtr
      841 itqlsllrhs stkeerpril siwpsakilt qvsklgphlh lsgncylkit alnldgqhlf
      901 eitnleklen lkwasfsnnn ltkmeglesc inleeltldg nciskiegis kmtkltrlsi
      961 nnnlltgwee htfdnmlhlh slslennrit slsglqksft lvelyisnny iavnqemhnl
     1021 kglcnlvild mcgniiiwnq enyrlfvifh lpelkaldgi piepsetdsa kdlfggrlts
     1081 dmiaerqghs nfkqmqelnw tsssirtvdl ipvdqfrnvc nvnlqnnhlt sfsgliylpn
     1141 vkvlclnynh iesimprlkp qthltsrqll yqkvpssgyg qqgisktnrd imssenlppi
     1201 mhslevlhlg yngicnliql qlnrlrnlkf lflqgneisq vegldnlvvl qelvvdhnri
     1261 rsfndsafak pssllalhle enrlrelgkl qslvkleklf lgynkiqdit elekldvist
     1321 lreltvygnp mldgspvnsd drakaefhla elqakknsli pvthspmdgr sfgqvktppi
     1381 eitnvllpsg fshylgsdvt ltpevedkkn knagiltnnp rsihaeiafr qlrgisisps
     1441 llshqniasp taqiyqsnqd krrifgsnfp rsnrm
//
LOCUS       XP_024305335            1450 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 9 isoform X3 [Homo sapiens].
ACCESSION   XP_024305335
VERSION     XP_024305335.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449567.2
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 38% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1450
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1450
                     /product="leucine-rich repeat-containing protein 9 isoform
                     X3"
                     /calculated_mol_wt=166209
     Region          37..51
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          55..236
                     /region_name="PPP1R42"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     cl42388"
                     /db_xref="CDD:455733"
     Region          56..77
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          78..99
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          100..121
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          122..143
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          144..166
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          192..223
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          587..972
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          654..673
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          674..695
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          696..717
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          718..744
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          745..802
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          803..866
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          834..1022
                     /region_name="PPP1R42"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     cl42388"
                     /db_xref="CDD:455733"
     Region          867..888
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          889..910
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          911..934
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          982..1050
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1072..1317
                     /region_name="PPP1R42"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     cl42388"
                     /db_xref="CDD:455733"
     Region          1097..1122
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1123..1159
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1160..1183
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1184..1205
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1206..1229
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1230..1251
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1252..1276
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     CDS             1..1450
                     /gene="LRRC9"
                     /coded_by="XM_024449567.2:205..4557"
                     /db_xref="GeneID:341883"
                     /db_xref="HGNC:HGNC:19848"
ORIGIN      
        1 miesenlnqe eiikelclcn glsyemvgqe gsdtsklemf flgyprivgl slfpnltslt
       61 ivaqdikeis glepclqlke lwiaecciek ieglqecrnl eklylyfnki skienlekli
      121 klkvlwlnhn tiknieglqt lknlkdlnla gnlinsigrc ldsneqlerl nlsgnqicsf
      181 keltnltrlp clkdlclndp qyttnpvcll cnysthvlyh lpclqrfdtl dvsakqikel
      241 adttamkkim yynmriktlq rhlkedlekl ndqkcklqkl peervklfsf vkktlerela
      301 elkgsgkghs dgsnnskvtd petlkscetv teepslqqki laklnalner vtfwnkklde
      361 fnfcyelils rfcawdfrty gitgvkvkri ikvnnrilrl kfeekfqkfl enedmhdses
      421 yrrmleclfy vfdpevsvkk khllqilekg fkdsetsklp lkkeaiivsn slsisecpri
      481 eflqqkhkde kkislkhelf rhgillitkv flgqsvqahe kesisqsnyp mvnsvfiprk
      541 yllnsvmgqr ncdcsvrqck wfvfdhdlvl peyvvefeyi tmvkapslfs vfnnvilees
      601 kknpevsvfs kdlkfddevi kmeprikarp klislddkti lslaktsvys hivslnlhgn
      661 slsklrdlsk ltglrklnis fneftclddv yhlynleyld ashnhvitle gfrglmklkh
      721 ldlswnqlkk sgneinmlck httslltldi qhnpwqkpat lrlsvigrlk tlthlngvfi
      781 seeeataamk fiagtritql sllrhsstke erprilsiwp sakiltqvsk lgphlhlsgn
      841 cylkitalnl dgqhlfeitn leklenlkwa sfsnnnltkm eglescinle eltldgncis
      901 kiegiskmtk ltrlsinnnl ltgweehtfd nmlhlhslsl ennritslsg lqksftlvel
      961 yisnnyiavn qemhnlkglc nlvildmcgn iiiwnqenyr lfvifhlpel kaldgipiep
     1021 setdsakdlf ggrltsdmia erqghsnfkq mqelnwtsss irtvdlipvd qfrnvcnvnl
     1081 qnnhltsfsg liylpnvkvl clnynhiesi mprlkpqthl tsrqllyqkv pssgygqqgi
     1141 sktnrdimss enlppimhsl evlhlgyngi cnliqlqlnr lrnlkflflq gneisqvegl
     1201 dnlvvlqelv vdhnrirsfn dsafakpssl lalhleenrl relgklqslv kleklflgyn
     1261 kiqditelek ldvistlrel tvygnpicrk mlhrhmlifr lpnlqmldgs pvnsddraka
     1321 efhlaelqak knslipvths pmdgrsfgqv ktppieitnv llpsgfshyl gsdvtltpev
     1381 edkknknagi ltnnprsiha eiafrqlrgi sispsllshq niasptaqiy qsnqdkrrif
     1441 gsnfprsnrm
//
LOCUS       XP_024305336            1450 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 9 isoform X3 [Homo sapiens].
ACCESSION   XP_024305336
VERSION     XP_024305336.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449568.2
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 38% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1450
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1450
                     /product="leucine-rich repeat-containing protein 9 isoform
                     X3"
                     /calculated_mol_wt=166209
     Region          37..51
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          55..236
                     /region_name="PPP1R42"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     cl42388"
                     /db_xref="CDD:455733"
     Region          56..77
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          78..99
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          100..121
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          122..143
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          144..166
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          192..223
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          587..972
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          654..673
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          674..695
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          696..717
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          718..744
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          745..802
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          803..866
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          834..1022
                     /region_name="PPP1R42"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     cl42388"
                     /db_xref="CDD:455733"
     Region          867..888
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          889..910
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          911..934
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          982..1050
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1072..1317
                     /region_name="PPP1R42"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     cl42388"
                     /db_xref="CDD:455733"
     Region          1097..1122
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1123..1159
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1160..1183
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1184..1205
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1206..1229
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1230..1251
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1252..1276
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     CDS             1..1450
                     /gene="LRRC9"
                     /coded_by="XM_024449568.2:164..4516"
                     /db_xref="GeneID:341883"
                     /db_xref="HGNC:HGNC:19848"
ORIGIN      
        1 miesenlnqe eiikelclcn glsyemvgqe gsdtsklemf flgyprivgl slfpnltslt
       61 ivaqdikeis glepclqlke lwiaecciek ieglqecrnl eklylyfnki skienlekli
      121 klkvlwlnhn tiknieglqt lknlkdlnla gnlinsigrc ldsneqlerl nlsgnqicsf
      181 keltnltrlp clkdlclndp qyttnpvcll cnysthvlyh lpclqrfdtl dvsakqikel
      241 adttamkkim yynmriktlq rhlkedlekl ndqkcklqkl peervklfsf vkktlerela
      301 elkgsgkghs dgsnnskvtd petlkscetv teepslqqki laklnalner vtfwnkklde
      361 fnfcyelils rfcawdfrty gitgvkvkri ikvnnrilrl kfeekfqkfl enedmhdses
      421 yrrmleclfy vfdpevsvkk khllqilekg fkdsetsklp lkkeaiivsn slsisecpri
      481 eflqqkhkde kkislkhelf rhgillitkv flgqsvqahe kesisqsnyp mvnsvfiprk
      541 yllnsvmgqr ncdcsvrqck wfvfdhdlvl peyvvefeyi tmvkapslfs vfnnvilees
      601 kknpevsvfs kdlkfddevi kmeprikarp klislddkti lslaktsvys hivslnlhgn
      661 slsklrdlsk ltglrklnis fneftclddv yhlynleyld ashnhvitle gfrglmklkh
      721 ldlswnqlkk sgneinmlck httslltldi qhnpwqkpat lrlsvigrlk tlthlngvfi
      781 seeeataamk fiagtritql sllrhsstke erprilsiwp sakiltqvsk lgphlhlsgn
      841 cylkitalnl dgqhlfeitn leklenlkwa sfsnnnltkm eglescinle eltldgncis
      901 kiegiskmtk ltrlsinnnl ltgweehtfd nmlhlhslsl ennritslsg lqksftlvel
      961 yisnnyiavn qemhnlkglc nlvildmcgn iiiwnqenyr lfvifhlpel kaldgipiep
     1021 setdsakdlf ggrltsdmia erqghsnfkq mqelnwtsss irtvdlipvd qfrnvcnvnl
     1081 qnnhltsfsg liylpnvkvl clnynhiesi mprlkpqthl tsrqllyqkv pssgygqqgi
     1141 sktnrdimss enlppimhsl evlhlgyngi cnliqlqlnr lrnlkflflq gneisqvegl
     1201 dnlvvlqelv vdhnrirsfn dsafakpssl lalhleenrl relgklqslv kleklflgyn
     1261 kiqditelek ldvistlrel tvygnpicrk mlhrhmlifr lpnlqmldgs pvnsddraka
     1321 efhlaelqak knslipvths pmdgrsfgqv ktppieitnv llpsgfshyl gsdvtltpev
     1381 edkknknagi ltnnprsiha eiafrqlrgi sispsllshq niasptaqiy qsnqdkrrif
     1441 gsnfprsnrm
//
LOCUS       XP_024305337            1426 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 9 isoform X4 [Homo sapiens].
ACCESSION   XP_024305337
VERSION     XP_024305337.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449569.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1426
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1426
                     /product="leucine-rich repeat-containing protein 9 isoform
                     X4"
                     /calculated_mol_wt=163650
     Region          37..51
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          55..236
                     /region_name="PPP1R42"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     cl42388"
                     /db_xref="CDD:455733"
     Region          56..77
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          78..99
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          100..121
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          122..143
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          144..166
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          192..223
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          631..1016
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          698..717
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          718..739
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          740..761
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          762..788
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          789..846
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          847..910
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          878..1066
                     /region_name="PPP1R42"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     cl42388"
                     /db_xref="CDD:455733"
     Region          911..932
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          933..954
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          955..978
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1026..1094
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1116..1361
                     /region_name="PPP1R42"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     cl42388"
                     /db_xref="CDD:455733"
     Region          1141..1166
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1167..1203
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1204..1227
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1228..1249
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1250..1273
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1274..1295
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1296..1320
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     CDS             1..1426
                     /gene="LRRC9"
                     /coded_by="XM_024449569.1:205..4485"
                     /db_xref="GeneID:341883"
                     /db_xref="HGNC:HGNC:19848"
ORIGIN      
        1 miesenlnqe eiikelclcn glsyemvgqe gsdtsklemf flgyprivgl slfpnltslt
       61 ivaqdikeis glepclqlke lwiaecciek ieglqecrnl eklylyfnki skienlekli
      121 klkvlwlnhn tiknieglqt lknlkdlnla gnlinsigrc ldsneqlerl nlsgnqicsf
      181 keltnltrlp clkdlclndp qyttnpvcll cnysthvlyh lpclqrfdtl dvsakqikel
      241 adttamkkim yynmriktlq rhlkedlekl ndqkcklqkl peervklfsf vkktlerela
      301 elkgsgkghs dgsnnskvtd petlkscetv teepslqqki laklnalner vtfwnkklde
      361 ieaiyhievk qkkkshglli plllieletv gnfhfeegtr sddwfnfcye lilsrfcawd
      421 frtygitgvk vkriikvnnr ilrlkfeekf qkflenedmh dsesyrrmle clfyvfdpev
      481 svkkkhllqi lekgfkdset sklplkkeai ivsnslsise cprieflqqk hkdekkislk
      541 helfrhgill itkvflgqsv qahekesisq snypmvnsvf iprkyllnsv mgqrncdcsv
      601 rqckwfvfdh dlvlpeyvve feyitmvkap slfsvfnnvi leeskknpev svfskdlkfd
      661 devikmepri karpklisld dktilslakt svyshivsln lhgnslsklr dlskltglrk
      721 lnisfneftc lddvyhlynl eyldashnhv itlegfrglm klkhldlswn qlkksgnein
      781 mlckhttsll tldiqhnpwq kpatlrlsvi grlktlthln gvfiseeeat aamkfiagtr
      841 itqlsllrhs stkeerpril siwpsakilt qvsklgphlh lsgncylkit alnldgqhlf
      901 eitnleklen lkwasfsnnn ltkmeglesc inleeltldg nciskiegis kmtkltrlsi
      961 nnnlltgwee htfdnmlhlh slslennrit slsglqksft lvelyisnny iavnqemhnl
     1021 kglcnlvild mcgniiiwnq enyrlfvifh lpelkaldgi piepsetdsa kdlfggrlts
     1081 dmiaerqghs nfkqmqelnw tsssirtvdl ipvdqfrnvc nvnlqnnhlt sfsgliylpn
     1141 vkvlclnynh iesimprlkp qthltsrqll yqkvpssgyg qqgisktnrd imssenlppi
     1201 mhslevlhlg yngicnliql qlnrlrnlkf lflqgneisq vegldnlvvl qelvvdhnri
     1261 rsfndsafak pssllalhle enrlrelgkl qslvkleklf lgynkiqdit elekldvist
     1321 lreltvygnp icrkmlhrhm lifrlpnlqm ldgspvnsdd rakaefhlae lqakknslip
     1381 vthspmdgrs fgqvktppie itnvllpsgf shylgsdvtl tpevev
//
LOCUS       XP_024305338            1331 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 9 isoform X5 [Homo sapiens].
ACCESSION   XP_024305338
VERSION     XP_024305338.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449570.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1331
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1331
                     /product="leucine-rich repeat-containing protein 9 isoform
                     X5"
                     /calculated_mol_wt=153082
     Region          37..51
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          55..236
                     /region_name="PPP1R42"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     cl42388"
                     /db_xref="CDD:455733"
     Region          56..77
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          78..99
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          100..121
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          122..143
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          144..166
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          192..223
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          628..1016
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          698..717
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          718..739
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          740..761
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          762..788
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          789..846
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          847..910
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          878..1066
                     /region_name="PPP1R42"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     cl42388"
                     /db_xref="CDD:455733"
     Region          911..932
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          933..954
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          955..978
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1026..1094
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1116..1331
                     /region_name="PPP1R42"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     cl42388"
                     /db_xref="CDD:455733"
     Region          1121..1140
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1141..1166
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1167..1203
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1228..1249
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1250..1273
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1274..1295
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1296..1320
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     CDS             1..1331
                     /gene="LRRC9"
                     /coded_by="XM_024449570.1:205..4200"
                     /db_xref="GeneID:341883"
                     /db_xref="HGNC:HGNC:19848"
ORIGIN      
        1 miesenlnqe eiikelclcn glsyemvgqe gsdtsklemf flgyprivgl slfpnltslt
       61 ivaqdikeis glepclqlke lwiaecciek ieglqecrnl eklylyfnki skienlekli
      121 klkvlwlnhn tiknieglqt lknlkdlnla gnlinsigrc ldsneqlerl nlsgnqicsf
      181 keltnltrlp clkdlclndp qyttnpvcll cnysthvlyh lpclqrfdtl dvsakqikel
      241 adttamkkim yynmriktlq rhlkedlekl ndqkcklqkl peervklfsf vkktlerela
      301 elkgsgkghs dgsnnskvtd petlkscetv teepslqqki laklnalner vtfwnkklde
      361 ieaiyhievk qkkkshglli plllieletv gnfhfeegtr sddwfnfcye lilsrfcawd
      421 frtygitgvk vkriikvnnr ilrlkfeekf qkflenedmh dsesyrrmle clfyvfdpev
      481 svkkkhllqi lekgfkdset sklplkkeai ivsnslsise cprieflqqk hkdekkislk
      541 helfrhgill itkvflgqsv qahekesisq snypmvnsvf iprkyllnsv mgqrncdcsv
      601 rqckwfvfdh dlvlpeyvve feyitmvkap slfsvfnnvi leeskknpev svfskdlkfd
      661 devikmepri karpklisld dktilslakt svyshivsln lhgnslsklr dlskltglrk
      721 lnisfneftc lddvyhlynl eyldashnhv itlegfrglm klkhldlswn qlkksgnein
      781 mlckhttsll tldiqhnpwq kpatlrlsvi grlktlthln gvfiseeeat aamkfiagtr
      841 itqlsllrhs stkeerpril siwpsakilt qvsklgphlh lsgncylkit alnldgqhlf
      901 eitnleklen lkwasfsnnn ltkmeglesc inleeltldg nciskiegis kmtkltrlsi
      961 nnnlltgwee htfdnmlhlh slslennrit slsglqksft lvelyisnny iavnqemhnl
     1021 kglcnlvild mcgniiiwnq enyrlfvifh lpelkaldgi piepsetdsa kdlfggrlts
     1081 dmiaerqghs nfkqmqelnw tsssirtvdl ipvdqfrnvc nvnlqnnhlt sfsgliylpn
     1141 vkvlclnynh iesimprlkp qthltsrqll yqkvpssgyg qqgisktnrd imssenlppi
     1201 mhslevlhlg yngicnliql qlnrlrnlkf lflqgneisq vegldnlvvl qelvvdhnri
     1261 rsfndsafak pssllalhle enrlrelgkl qslvkleklf lgynkiqdit elekldvist
     1321 lreltvygnp f
//
LOCUS       XP_047287301            1249 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 9 isoform X6 [Homo sapiens].
ACCESSION   XP_047287301
VERSION     XP_047287301.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431345.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 45% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1249
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1249
                     /product="leucine-rich repeat-containing protein 9 isoform
                     X6"
                     /calculated_mol_wt=143424
     Region          386..771
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          453..472
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          473..494
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          495..516
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          517..543
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          544..601
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          602..665
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          633..821
                     /region_name="PPP1R42"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     cl42388"
                     /db_xref="CDD:455733"
     Region          666..687
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          688..709
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          710..733
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          781..849
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          871..1116
                     /region_name="PPP1R42"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     cl42388"
                     /db_xref="CDD:455733"
     Region          896..921
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          922..958
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          959..982
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          983..1004
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1005..1028
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1029..1050
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1051..1075
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     CDS             1..1249
                     /gene="LRRC9"
                     /coded_by="XM_047431345.1:640..4389"
                     /db_xref="GeneID:341883"
                     /db_xref="HGNC:HGNC:19848"
ORIGIN      
        1 mkkimyynmr iktlqrhlke dleklndqkc klqklpeerv klfsfvkktl erelaelkgs
       61 gkghsdgsnn skvtdpetlk scetvteeps lqqkilakln alnervtfwn kkldeieaiy
      121 hievkqkkks hgllipllli eletvgnfhf eegtrsddwf nfcyelilsr fcawdfrtyg
      181 itgvkvkrii kvnnrilrlk feekfqkfle nedmhdsesy rrmleclfyv fdpevsvkkk
      241 hllqilekgf kdsetsklpl kkeaiivsns lsisecprie flqqkhkdek kislkhelfr
      301 hgillitkvf lgqsvqahek esisqsnypm vnsvfiprky llnsvmgqrn cdcsvrqckw
      361 fvfdhdlvlp eyvvefeyit mvkapslfsv fnnvileesk knpevsvfsk dlkfddevik
      421 meprikarpk lislddktil slaktsvysh ivslnlhgns lsklrdlskl tglrklnisf
      481 neftclddvy hlynleylda shnhvitleg frglmklkhl dlswnqlkks gneinmlckh
      541 ttslltldiq hnpwqkpatl rlsvigrlkt lthlngvfis eeeataamkf iagtritqls
      601 llrhsstkee rprilsiwps akiltqvskl gphlhlsgnc ylkitalnld gqhlfeitnl
      661 eklenlkwas fsnnnltkme glescinlee ltldgncisk iegiskmtkl trlsinnnll
      721 tgweehtfdn mlhlhslsle nnritslsgl qksftlvely isnnyiavnq emhnlkglcn
      781 lvildmcgni iiwnqenyrl fvifhlpelk aldgipieps etdsakdlfg grltsdmiae
      841 rqghsnfkqm qelnwtsssi rtvdlipvdq frnvcnvnlq nnhltsfsgl iylpnvkvlc
      901 lnynhiesim prlkpqthlt srqllyqkvp ssgygqqgis ktnrdimsse nlppimhsle
      961 vlhlgyngic nliqlqlnrl rnlkflflqg neisqvegld nlvvlqelvv dhnrirsfnd
     1021 safakpssll alhleenrlr elgklqslvk leklflgynk iqditelekl dvistlrelt
     1081 vygnpicrkm lhrhmlifrl pnlqmldgsp vnsddrakae fhlaelqakk nslipvthsp
     1141 mdgrsfgqvk tppieitnvl lpsgfshylg sdvtltpeve dkknknagil tnnprsihae
     1201 iafrqlrgis ispsllshqn iasptaqiyq snqdkrrifg snfprsnrm
//
LOCUS       XP_024305339             901 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 9 isoform X7 [Homo sapiens].
ACCESSION   XP_024305339
VERSION     XP_024305339.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449571.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..901
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..901
                     /product="leucine-rich repeat-containing protein 9 isoform
                     X7"
                     /calculated_mol_wt=104574
     Region          37..51
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          55..236
                     /region_name="PPP1R42"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     cl42388"
                     /db_xref="CDD:455733"
     Region          56..77
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          78..99
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          100..121
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          122..143
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          144..166
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          192..223
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          <694..828
                     /region_name="PPP1R42"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     cl42388"
                     /db_xref="CDD:455733"
     Region          696..717
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          718..739
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          740..761
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          762..788
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          789..800
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     CDS             1..901
                     /gene="LRRC9"
                     /coded_by="XM_024449571.2:205..2910"
                     /db_xref="GeneID:341883"
                     /db_xref="HGNC:HGNC:19848"
ORIGIN      
        1 miesenlnqe eiikelclcn glsyemvgqe gsdtsklemf flgyprivgl slfpnltslt
       61 ivaqdikeis glepclqlke lwiaecciek ieglqecrnl eklylyfnki skienlekli
      121 klkvlwlnhn tiknieglqt lknlkdlnla gnlinsigrc ldsneqlerl nlsgnqicsf
      181 keltnltrlp clkdlclndp qyttnpvcll cnysthvlyh lpclqrfdtl dvsakqikel
      241 adttamkkim yynmriktlq rhlkedlekl ndqkcklqkl peervklfsf vkktlerela
      301 elkgsgkghs dgsnnskvtd petlkscetv teepslqqki laklnalner vtfwnkklde
      361 ieaiyhievk qkkkshglli plllieletv gnfhfeegtr sddwfnfcye lilsrfcawd
      421 frtygitgvk vkriikvnnr ilrlkfeekf qkflenedmh dsesyrrmle clfyvfdpev
      481 svkkkhllqi lekgfkdset sklplkkeai ivsnslsise cprieflqqk hkdekkislk
      541 helfrhgill itkvflgqsv qahekesisq snypmvnsvf iprkyllnsv mgqrncdcsv
      601 rqckwfvfdh dlvlpeyvve feyitmvkap slfsvfnnvi leeskknpev svfskdlkfd
      661 devikmepri karpklisld dktilslakt svyshivsln lhgnslsklr dlskltglrk
      721 lnisfneftc lddvyhlynl eyldashnhv itlegfrglm klkhldlswn qlkksgnein
      781 mlckhttsll tldiqhnpwq kpatlrlsvi grlktlthln gvfiseeeat aamkfiagtr
      841 itqkvkrqat ywekkfatql skdilyisri ykekdnqpnr nmcrrsehtl hwrgnqnsql
      901 t
//
LOCUS       XP_024305340             847 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 9 isoform X8 [Homo sapiens].
ACCESSION   XP_024305340
VERSION     XP_024305340.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449572.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..847
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..847
                     /product="leucine-rich repeat-containing protein 9 isoform
                     X8"
                     /calculated_mol_wt=97915
     Region          37..51
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          55..236
                     /region_name="PPP1R42"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     cl42388"
                     /db_xref="CDD:455733"
     Region          56..77
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          78..99
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          100..121
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          122..143
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          144..166
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          192..223
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          <694..828
                     /region_name="PPP1R42"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     cl42388"
                     /db_xref="CDD:455733"
     Region          696..717
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          718..739
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          740..761
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          762..788
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          789..800
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     CDS             1..847
                     /gene="LRRC9"
                     /coded_by="XM_024449572.2:205..2748"
                     /db_xref="GeneID:341883"
                     /db_xref="HGNC:HGNC:19848"
ORIGIN      
        1 miesenlnqe eiikelclcn glsyemvgqe gsdtsklemf flgyprivgl slfpnltslt
       61 ivaqdikeis glepclqlke lwiaecciek ieglqecrnl eklylyfnki skienlekli
      121 klkvlwlnhn tiknieglqt lknlkdlnla gnlinsigrc ldsneqlerl nlsgnqicsf
      181 keltnltrlp clkdlclndp qyttnpvcll cnysthvlyh lpclqrfdtl dvsakqikel
      241 adttamkkim yynmriktlq rhlkedlekl ndqkcklqkl peervklfsf vkktlerela
      301 elkgsgkghs dgsnnskvtd petlkscetv teepslqqki laklnalner vtfwnkklde
      361 ieaiyhievk qkkkshglli plllieletv gnfhfeegtr sddwfnfcye lilsrfcawd
      421 frtygitgvk vkriikvnnr ilrlkfeekf qkflenedmh dsesyrrmle clfyvfdpev
      481 svkkkhllqi lekgfkdset sklplkkeai ivsnslsise cprieflqqk hkdekkislk
      541 helfrhgill itkvflgqsv qahekesisq snypmvnsvf iprkyllnsv mgqrncdcsv
      601 rqckwfvfdh dlvlpeyvve feyitmvkap slfsvfnnvi leeskknpev svfskdlkfd
      661 devikmepri karpklisld dktilslakt svyshivsln lhgnslsklr dlskltglrk
      721 lnisfneftc lddvyhlynl eyldashnhv itlegfrglm klkhldlswn qlkksgnein
      781 mlckhttsll tldiqhnpwq kpatlrlsvi grlktlthln gvfiseeeat aamkfiagtr
      841 itqvhil
//
LOCUS       XP_024305341             846 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 9 isoform X9 [Homo sapiens].
ACCESSION   XP_024305341
VERSION     XP_024305341.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449573.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..846
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..846
                     /product="leucine-rich repeat-containing protein 9 isoform
                     X9"
                     /calculated_mol_wt=97806
     Region          37..51
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          55..236
                     /region_name="PPP1R42"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     cl42388"
                     /db_xref="CDD:455733"
     Region          56..77
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          78..99
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          100..121
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          122..143
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          144..166
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          192..223
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          <694..828
                     /region_name="PPP1R42"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     cl42388"
                     /db_xref="CDD:455733"
     Region          696..717
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          718..739
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          740..761
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          762..788
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          789..800
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     CDS             1..846
                     /gene="LRRC9"
                     /coded_by="XM_024449573.2:205..2745"
                     /db_xref="GeneID:341883"
                     /db_xref="HGNC:HGNC:19848"
ORIGIN      
        1 miesenlnqe eiikelclcn glsyemvgqe gsdtsklemf flgyprivgl slfpnltslt
       61 ivaqdikeis glepclqlke lwiaecciek ieglqecrnl eklylyfnki skienlekli
      121 klkvlwlnhn tiknieglqt lknlkdlnla gnlinsigrc ldsneqlerl nlsgnqicsf
      181 keltnltrlp clkdlclndp qyttnpvcll cnysthvlyh lpclqrfdtl dvsakqikel
      241 adttamkkim yynmriktlq rhlkedlekl ndqkcklqkl peervklfsf vkktlerela
      301 elkgsgkghs dgsnnskvtd petlkscetv teepslqqki laklnalner vtfwnkklde
      361 ieaiyhievk qkkkshglli plllieletv gnfhfeegtr sddwfnfcye lilsrfcawd
      421 frtygitgvk vkriikvnnr ilrlkfeekf qkflenedmh dsesyrrmle clfyvfdpev
      481 svkkkhllqi lekgfkdset sklplkkeai ivsnslsise cprieflqqk hkdekkislk
      541 helfrhgill itkvflgqsv qahekesisq snypmvnsvf iprkyllnsv mgqrncdcsv
      601 rqckwfvfdh dlvlpeyvve feyitmvkap slfsvfnnvi leeskknpev svfskdlkfd
      661 devikmepri karpklisld dktilslakt svyshivsln lhgnslsklr dlskltglrk
      721 lnisfneftc lddvyhlynl eyldashnhv itlegfrglm klkhldlswn qlkksgnein
      781 mlckhttsll tldiqhnpwq kpatlrlsvi grlktlthln gvfiseeeat aamkfiagtr
      841 itqesh
//
LOCUS       XP_024305342             844 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 9 isoform X10 [Homo
            sapiens].
ACCESSION   XP_024305342
VERSION     XP_024305342.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449574.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..844
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..844
                     /product="leucine-rich repeat-containing protein 9 isoform
                     X10"
                     /calculated_mol_wt=97616
     Region          37..51
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          55..236
                     /region_name="PPP1R42"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     cl42388"
                     /db_xref="CDD:455733"
     Region          56..77
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          78..99
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          100..121
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          122..143
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          144..166
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          192..223
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          <694..828
                     /region_name="PPP1R42"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     cl42388"
                     /db_xref="CDD:455733"
     Region          696..717
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          718..739
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          740..761
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          762..788
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          789..800
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     CDS             1..844
                     /gene="LRRC9"
                     /coded_by="XM_024449574.2:205..2739"
                     /db_xref="GeneID:341883"
                     /db_xref="HGNC:HGNC:19848"
ORIGIN      
        1 miesenlnqe eiikelclcn glsyemvgqe gsdtsklemf flgyprivgl slfpnltslt
       61 ivaqdikeis glepclqlke lwiaecciek ieglqecrnl eklylyfnki skienlekli
      121 klkvlwlnhn tiknieglqt lknlkdlnla gnlinsigrc ldsneqlerl nlsgnqicsf
      181 keltnltrlp clkdlclndp qyttnpvcll cnysthvlyh lpclqrfdtl dvsakqikel
      241 adttamkkim yynmriktlq rhlkedlekl ndqkcklqkl peervklfsf vkktlerela
      301 elkgsgkghs dgsnnskvtd petlkscetv teepslqqki laklnalner vtfwnkklde
      361 ieaiyhievk qkkkshglli plllieletv gnfhfeegtr sddwfnfcye lilsrfcawd
      421 frtygitgvk vkriikvnnr ilrlkfeekf qkflenedmh dsesyrrmle clfyvfdpev
      481 svkkkhllqi lekgfkdset sklplkkeai ivsnslsise cprieflqqk hkdekkislk
      541 helfrhgill itkvflgqsv qahekesisq snypmvnsvf iprkyllnsv mgqrncdcsv
      601 rqckwfvfdh dlvlpeyvve feyitmvkap slfsvfnnvi leeskknpev svfskdlkfd
      661 devikmepri karpklisld dktilslakt svyshivsln lhgnslsklr dlskltglrk
      721 lnisfneftc lddvyhlynl eyldashnhv itlegfrglm klkhldlswn qlkksgnein
      781 mlckhttsll tldiqhnpwq kpatlrlsvi grlktlthln gvfiseeeat aamkfiagtr
      841 itqy
//
LOCUS       XP_024305343             803 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 9 isoform X11 [Homo
            sapiens].
ACCESSION   XP_024305343
VERSION     XP_024305343.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449575.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..803
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..803
                     /product="leucine-rich repeat-containing protein 9 isoform
                     X11"
                     /calculated_mol_wt=93149
     Region          37..51
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          55..236
                     /region_name="PPP1R42"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     cl42388"
                     /db_xref="CDD:455733"
     Region          56..77
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          78..99
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          100..121
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          122..143
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          144..166
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          192..223
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          <694..>798
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          696..717
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          718..739
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          740..761
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          762..788
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          789..800
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     CDS             1..803
                     /gene="LRRC9"
                     /coded_by="XM_024449575.2:205..2616"
                     /db_xref="GeneID:341883"
                     /db_xref="HGNC:HGNC:19848"
ORIGIN      
        1 miesenlnqe eiikelclcn glsyemvgqe gsdtsklemf flgyprivgl slfpnltslt
       61 ivaqdikeis glepclqlke lwiaecciek ieglqecrnl eklylyfnki skienlekli
      121 klkvlwlnhn tiknieglqt lknlkdlnla gnlinsigrc ldsneqlerl nlsgnqicsf
      181 keltnltrlp clkdlclndp qyttnpvcll cnysthvlyh lpclqrfdtl dvsakqikel
      241 adttamkkim yynmriktlq rhlkedlekl ndqkcklqkl peervklfsf vkktlerela
      301 elkgsgkghs dgsnnskvtd petlkscetv teepslqqki laklnalner vtfwnkklde
      361 ieaiyhievk qkkkshglli plllieletv gnfhfeegtr sddwfnfcye lilsrfcawd
      421 frtygitgvk vkriikvnnr ilrlkfeekf qkflenedmh dsesyrrmle clfyvfdpev
      481 svkkkhllqi lekgfkdset sklplkkeai ivsnslsise cprieflqqk hkdekkislk
      541 helfrhgill itkvflgqsv qahekesisq snypmvnsvf iprkyllnsv mgqrncdcsv
      601 rqckwfvfdh dlvlpeyvve feyitmvkap slfsvfnnvi leeskknpev svfskdlkfd
      661 devikmepri karpklisld dktilslakt svyshivsln lhgnslsklr dlskltglrk
      721 lnisfneftc lddvyhlynl eyldashnhv itlegfrglm klkhldlswn qlkksgnein
      781 mlckhttsll tldiqhnpwq kph
//
LOCUS       XP_047287302             154 aa            linear   PRI 05-AUG-2025
DEFINITION  interferon alpha-inducible protein 27, mitochondrial isoform X1
            [Homo sapiens].
ACCESSION   XP_047287302
VERSION     XP_047287302.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431346.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..154
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..154
                     /product="interferon alpha-inducible protein 27,
                     mitochondrial isoform X1"
                     /calculated_mol_wt=16381
     CDS             1..154
                     /gene="IFI27"
                     /gene_synonym="FAM14D; ISG12; ISG12A; P27"
                     /coded_by="XM_047431346.1:16..480"
                     /db_xref="GeneID:3429"
                     /db_xref="HGNC:HGNC:5397"
                     /db_xref="MIM:600009"
ORIGIN      
        1 mgsasvgvel lkrpgitpfg ntsklktvrs ashsqelsff gqdcyscdwr scghggcahg
       61 aqchglhcgg nrlvlhssqd dvrgghcqwg wsclgqpcgy savtgsnwtl ridqvhpglh
      121 wvchcgchce vllapcpspc reenhargeg tqps
//
LOCUS       XP_047287305             122 aa            linear   PRI 05-AUG-2025
DEFINITION  interferon alpha-inducible protein 27, mitochondrial isoform X2
            [Homo sapiens].
ACCESSION   XP_047287305
VERSION     XP_047287305.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431349.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..122
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..122
                     /product="interferon alpha-inducible protein 27,
                     mitochondrial isoform X2"
                     /calculated_mol_wt=11411
     Region          37..115
                     /region_name="Ifi-6-16"
                     /note="Interferon-induced 6-16 family; pfam06140"
                     /db_xref="CDD:461837"
     CDS             1..122
                     /gene="IFI27"
                     /gene_synonym="FAM14D; ISG12; ISG12A; P27"
                     /coded_by="XM_047431349.1:140..508"
                     /db_xref="GeneID:3429"
                     /db_xref="HGNC:HGNC:5397"
                     /db_xref="MIM:600009"
ORIGIN      
        1 measaltssa vtsvakvvrv asgsavvlpl ariatvvigg vvamaavpmv lsamgftaag
       61 iasssiaakm msaaaiangg gvasgslvat lqslgatgls gltkfilgsi gsaiaaviar
      121 fy
//
LOCUS       XP_016876751             295 aa            linear   PRI 05-AUG-2025
DEFINITION  inositol-tetrakisphosphate 1-kinase isoform X1 [Homo sapiens].
ACCESSION   XP_016876751
VERSION     XP_016876751.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021262.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XP_016876751.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..295
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..295
                     /product="inositol-tetrakisphosphate 1-kinase isoform X1"
                     /calculated_mol_wt=31586
     Region          1..199
                     /region_name="Ins134_P3_kin"
                     /note="Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp
                     domain; pfam05770"
                     /db_xref="CDD:368606"
     CDS             1..295
                     /gene="ITPK1"
                     /gene_synonym="ITRPK1"
                     /coded_by="XM_017021262.2:363..1250"
                     /db_xref="GeneID:3705"
                     /db_xref="HGNC:HGNC:6177"
                     /db_xref="MIM:601838"
ORIGIN      
        1 meddricspp fmeltslcgd dtmrllekng ltfpficktr vahgtnshem aivfnqegln
       61 aiqppcvvqn finhnavlyk vfvvgesytv vqrpslknfs agtsdresif fnshnvskpe
      121 sssvlteldk iegvferpsd evirelsral rqalgvslfg idiiinnqtg qhavidinaf
      181 pgyegvseff tdllnhiatv lqgqstamaa tgdvallrhs kllaepaggl vgertcsasp
      241 gccgsmmgqd apwkaeadag gtaklphqrl gcnagvspsf qqhcvaslat kassq
//
LOCUS       XP_047287307             295 aa            linear   PRI 05-AUG-2025
DEFINITION  inositol-tetrakisphosphate 1-kinase isoform X1 [Homo sapiens].
ACCESSION   XP_047287307
VERSION     XP_047287307.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431351.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..295
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..295
                     /product="inositol-tetrakisphosphate 1-kinase isoform X1"
                     /calculated_mol_wt=31586
     Region          1..199
                     /region_name="Ins134_P3_kin"
                     /note="Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp
                     domain; pfam05770"
                     /db_xref="CDD:368606"
     CDS             1..295
                     /gene="ITPK1"
                     /gene_synonym="ITRPK1"
                     /coded_by="XM_047431351.1:629..1516"
                     /db_xref="GeneID:3705"
                     /db_xref="HGNC:HGNC:6177"
                     /db_xref="MIM:601838"
ORIGIN      
        1 meddricspp fmeltslcgd dtmrllekng ltfpficktr vahgtnshem aivfnqegln
       61 aiqppcvvqn finhnavlyk vfvvgesytv vqrpslknfs agtsdresif fnshnvskpe
      121 sssvlteldk iegvferpsd evirelsral rqalgvslfg idiiinnqtg qhavidinaf
      181 pgyegvseff tdllnhiatv lqgqstamaa tgdvallrhs kllaepaggl vgertcsasp
      241 gccgsmmgqd apwkaeadag gtaklphqrl gcnagvspsf qqhcvaslat kassq
//
LOCUS       XP_047287308            1124 aa            linear   PRI 05-AUG-2025
DEFINITION  protein jagged-2 isoform X1 [Homo sapiens].
ACCESSION   XP_047287308
VERSION     XP_047287308.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431352.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1124
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1124
                     /product="protein jagged-2 isoform X1"
                     /calculated_mol_wt=121105
     Region          <26..82
                     /region_name="MNNL"
                     /note="N terminus of Notch ligand C2-like domain;
                     pfam07657"
                     /db_xref="CDD:462222"
     Region          64..126
                     /region_name="DSL"
                     /note="delta serrate ligand; smart00051"
                     /db_xref="CDD:128366"
     Region          193..231
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(193,196,211)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          237..267
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          271..307
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(271,274,288)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          309..344
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(309,312,326)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          347..382
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(347,350,363)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          386..420
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          422..457
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(422,425,439)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          522..557
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(522,525,539)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          562..595
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          602..632
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          643..673
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          <683..710
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          713..749
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(713,716,730)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          758..829
                     /region_name="VWC_out"
                     /note="von Willebrand factor (vWF) type C domain;
                     smart00215"
                     /db_xref="CDD:214565"
     CDS             1..1124
                     /gene="JAG2"
                     /gene_synonym="HJ2; LGMDR27; SER2"
                     /coded_by="XM_047431352.1:291..3665"
                     /db_xref="GeneID:3714"
                     /db_xref="HGNC:HGNC:6189"
                     /db_xref="MIM:602570"
ORIGIN      
        1 mvtqdrsete ivdpgavtfc gtalfrsftl iveawdwdnd ttpneellie rvshagminp
       61 edrwkslhfs ghvahlelqi rvrcdenyys atcnkfcrpr ndffghytcd qygnkacmdg
      121 wmgkeckeav ckqgcnllhg gctvpgecrc sygwqgrfcd ecvpypgcvh gscvepwqcn
      181 cetnwggllc dkdlnycgsh hpctnggtci naepdqyrct cpdgysgrnc ekaehactsn
      241 pcanggsche vpsgfechcp sgwsgptcal didecasnpc aaggtcvdqv dgfecicpeq
      301 wvgatcqlda necegkpcln afscknligg yycdcipgwk ginchinvnd crgqcqhggt
      361 ckdlvngyqc vcprgfggrh celerdecas spchsgglce dladgfhchc pqgfsgplce
      421 vdvdlcepsp crngarcynl egdyycacpd dfggkncsvp repcpggacr vidgcgsdag
      481 pgmpgtaasg vcgphgrcvs qpggnfscic dsgftgtych eniddclgqp crnggtcide
      541 vdafrcfcps gwegelcdtn pndclpdpch srgrcydlvn dfycacddgw kgktchsref
      601 qcdaytcsng gtcydsgdtf rcacppgwkg stcavaknss clpnpcvngg tcvgsgasfs
      661 cicrdgwegr tcthntndcn plpcynggic vdgvnwfrce capgfagpdc rinidecqss
      721 pcaygatcvd eingyrcscp pgragprcqe vigfgrscws rgtpfphgss wvedcnscrc
      781 ldgrrdcskv wcgwkpclla gqpealsaqc plgqrcleka pgqclrppce awgecgaeep
      841 pstpclprsg hldnncarlt lhfnrdhvpq gttvgaicsg irslpatrav ardrllvllc
      901 drassgasav evavsfspar dlpdssliqg aahaivaait qrgnssllla vtevkvetvv
      961 tggsstgllv pvlcgafsvl wlacvvlcvw wtrkrrkere rsrlpreesa nnqwaplnpi
     1021 rnpierpggh kdvlyqcknf tppprradea lpgpaghaav redeededlg rgeedsleae
     1081 kflshkftkd pgrspgrpah wasgpkvdnr avrsineary agke
//
LOCUS       XP_047287309            1086 aa            linear   PRI 05-AUG-2025
DEFINITION  protein jagged-2 isoform X2 [Homo sapiens].
ACCESSION   XP_047287309
VERSION     XP_047287309.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431353.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1086
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1086
                     /product="protein jagged-2 isoform X2"
                     /calculated_mol_wt=116974
     Region          <26..82
                     /region_name="MNNL"
                     /note="N terminus of Notch ligand C2-like domain;
                     pfam07657"
                     /db_xref="CDD:462222"
     Region          64..126
                     /region_name="DSL"
                     /note="delta serrate ligand; smart00051"
                     /db_xref="CDD:128366"
     Region          193..231
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(193,196,211)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          237..267
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          271..307
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(271,274,288)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          309..344
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(309,312,325)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          348..382
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          384..419
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(384,387,401)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          484..519
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(484,487,501)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          524..557
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          564..594
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          605..635
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          <645..672
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          675..711
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(675,678,692)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          720..791
                     /region_name="VWC_out"
                     /note="von Willebrand factor (vWF) type C domain;
                     smart00215"
                     /db_xref="CDD:214565"
     CDS             1..1086
                     /gene="JAG2"
                     /gene_synonym="HJ2; LGMDR27; SER2"
                     /coded_by="XM_047431353.1:82..3342"
                     /db_xref="GeneID:3714"
                     /db_xref="HGNC:HGNC:6189"
                     /db_xref="MIM:602570"
ORIGIN      
        1 mvtqdrsete ivdpgavtfc gtalfrsftl iveawdwdnd ttpneellie rvshagminp
       61 edrwkslhfs ghvahlelqi rvrcdenyys atcnkfcrpr ndffghytcd qygnkacmdg
      121 wmgkeckeav ckqgcnllhg gctvpgecrc sygwqgrfcd ecvpypgcvh gscvepwqcn
      181 cetnwggllc dkdlnycgsh hpctnggtci naepdqyrct cpdgysgrnc ekaehactsn
      241 pcanggsche vpsgfechcp sgwsgptcal didecasnpc aaggtcvdqv dgfecicpeq
      301 wvgatcqldv ndcrgqcqhg gtckdlvngy qcvcprgfgg rhcelerdec asspchsggl
      361 cedladgfhc hcpqgfsgpl cevdvdlcep spcrngarcy nlegdyycac pddfggkncs
      421 vprepcpgga crvidgcgsd agpgmpgtaa sgvcgphgrc vsqpggnfsc icdsgftgty
      481 cheniddclg qpcrnggtci devdafrcfc psgwegelcd tnpndclpdp chsrgrcydl
      541 vndfycacdd gwkgktchsr efqcdaytcs nggtcydsgd tfrcacppgw kgstcavakn
      601 ssclpnpcvn ggtcvgsgas fscicrdgwe grtcthntnd cnplpcyngg icvdgvnwfr
      661 cecapgfagp dcrinidecq sspcaygatc vdeingyrcs cppgragprc qevigfgrsc
      721 wsrgtpfphg sswvedcnsc rcldgrrdcs kvwcgwkpcl lagqpealsa qcplgqrcle
      781 kapgqclrpp ceawgecgae eppstpclpr sghldnncar ltlhfnrdhv pqgttvgaic
      841 sgirslpatr avardrllvl lcdrassgas avevavsfsp ardlpdssli qgaahaivaa
      901 itqrgnssll lavtevkvet vvtggsstgl lvpvlcgafs vlwlacvvlc vwwtrkrrke
      961 rersrlpree sannqwapln pirnpierpg ghkdvlyqck nftppprrad ealpgpagha
     1021 avredeeded lgrgeedsle aekflshkft kdpgrspgrp ahwasgpkvd nravrsinea
     1081 ryagke
//
LOCUS       XP_047287310             749 aa            linear   PRI 05-AUG-2025
DEFINITION  protein jagged-2 isoform X3 [Homo sapiens].
ACCESSION   XP_047287310
VERSION     XP_047287310.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431354.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 12% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..749
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..749
                     /product="protein jagged-2 isoform X3"
                     /calculated_mol_wt=79389
     Region          28..196
                     /region_name="MNNL"
                     /note="N terminus of Notch ligand C2-like domain;
                     pfam07657"
                     /db_xref="CDD:462222"
     Region          178..240
                     /region_name="DSL"
                     /note="delta serrate ligand; smart00051"
                     /db_xref="CDD:128366"
     Region          307..345
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(307,310,325)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          351..381
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          385..421
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(385,388,402)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          423..458
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(423,426,440)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          461..496
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(461,464,477)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          500..534
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          536..571
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(536,539,553)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          636..671
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(636,639,653)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     CDS             1..749
                     /gene="JAG2"
                     /gene_synonym="HJ2; LGMDR27; SER2"
                     /coded_by="XM_047431354.1:357..2606"
                     /db_xref="GeneID:3714"
                     /db_xref="HGNC:HGNC:6189"
                     /db_xref="MIM:602570"
ORIGIN      
        1 mraqgrgrlp rrlllllalw vqaarpmgyf elqlsalrnv ngellsgacc dgdgrttrag
       61 gcghdecdty vrvclkeyqa kvtptgpcsy ghgatpvlgg nsfylppaga agdrararar
      121 aggdqdpglv vipfqfawpr sftliveawd wdndttpnee lliervshag minpedrwks
      181 lhfsghvahl elqirvrcde nyysatcnkf crprndffgh ytcdqygnka cmdgwmgkec
      241 keavckqgcn llhggctvpg ecrcsygwqg rfcdecvpyp gcvhgscvep wqcncetnwg
      301 gllcdkdlny cgshhpctng gtcinaepdq yrctcpdgys grncekaeha ctsnpcangg
      361 schevpsgfe chcpsgwsgp tcaldideca snpcaaggtc vdqvdgfeci cpeqwvgatc
      421 qldanecegk pclnafsckn liggyycdci pgwkginchi nvndcrgqcq hggtckdlvn
      481 gyqcvcprgf ggrhcelerd ecasspchsg glcedladgf hchcpqgfsg plcevdvdlc
      541 epspcrngar cynlegdyyc acpddfggkn csvprepcpg gacrvidgcg sdagpgmpgt
      601 aasgvcgphg rcvsqpggnf scicdsgftg tycheniddc lgqpcrnggt cidevdafrc
      661 fcpsgwegel cdttaaaatt wsmtstvrat tagrarpath asssamptpa atvapattaa
      721 tpsaapappa graapapspr taaacptpv
//
LOCUS       XP_016876754             670 aa            linear   PRI 05-AUG-2025
DEFINITION  60 kDa lysophospholipase isoform X1 [Homo sapiens].
ACCESSION   XP_016876754
VERSION     XP_016876754.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021265.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..670
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..670
                     /product="60 kDa lysophospholipase isoform X1"
                     /calculated_mol_wt=70552
     Region          102..389
                     /region_name="L-asparaginase_like"
                     /note="Bacterial L-asparaginases and related enzymes;
                     cl00216"
                     /db_xref="CDD:469665"
     Site            order(109,112..118,120..121,145..146,149,171..172,
                     216..221,265..275,277..278,281,284..285,294,296..298,302,
                     326,329..333,336,355,359,363)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:199207"
     Region          <435..>504
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          461..492
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     CDS             1..670
                     /gene="ASPG"
                     /gene_synonym="C14orf76; GPA/WT; hASNase1; LYSOLP"
                     /coded_by="XM_017021265.1:469..2481"
                     /db_xref="GeneID:374569"
                     /db_xref="HGNC:HGNC:20123"
                     /db_xref="MIM:618472"
ORIGIN      
        1 magpspplra gvgrrllgva hpdlrpclcg elqveggpgp vpgmlrtcyv rspwrrgpss
       61 argeqsgsgh leqeevqsgs llfrlllfls rspasrnqri lytvlecqpl fdssdmtiae
      121 wvclaqtikr hyeqyhgfvv ihgtdtmafa asmlsfmlen lqktviltga qvpihalwsd
      181 grenllgall magqyvipev clffqnqlfr gnratkvdar rfaafcspnl lplatvgadi
      241 tinrelvrkv dgkaglvvhs smeqdvgllr lypgipaalv raflqpplkg vvmetfgsgn
      301 gptkpdllqe lrvaterglv ivncthclqg avttdyaagm amagagvisg fdmtseaala
      361 klsyvlgqpg lsldvrkell tkdlrgemtp psveerrpsl qgntlgggvs wllslsgsqe
      421 adalrnalvp slacaaahag dvealqalve lgsdlglvdf ngqtplhaaa rgghteavtm
      481 llqrgvdvnt rdtdgfspll lavrgrtrlt arpqpvsqpr saarlpeaac lallclsgtp
      541 lsgcpaptpt qgqsagliqc plrlaeevtt gcdqrlgvqw grsahasgch wvaagsrglp
      601 vhpgaggsrd gavqpeslpp tpclvpgdla lppvpslgcp rpgrlrgtqk geseagdlgr
      661 vqvvagvgvl
//
LOCUS       XP_016876755             653 aa            linear   PRI 05-AUG-2025
DEFINITION  60 kDa lysophospholipase isoform X2 [Homo sapiens].
ACCESSION   XP_016876755
VERSION     XP_016876755.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021266.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..653
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..653
                     /product="60 kDa lysophospholipase isoform X2"
                     /calculated_mol_wt=68781
     Region          102..389
                     /region_name="L-asparaginase_like"
                     /note="Bacterial L-asparaginases and related enzymes;
                     cl00216"
                     /db_xref="CDD:469665"
     Site            order(109,112..118,120..121,145..146,149,171..172,
                     216..221,265..275,277..278,281,284..285,294,296..298,302,
                     326,329..333,336,355,359,363)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:199207"
     Region          <435..>504
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          461..492
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     CDS             1..653
                     /gene="ASPG"
                     /gene_synonym="C14orf76; GPA/WT; hASNase1; LYSOLP"
                     /coded_by="XM_017021266.2:469..2430"
                     /db_xref="GeneID:374569"
                     /db_xref="HGNC:HGNC:20123"
                     /db_xref="MIM:618472"
ORIGIN      
        1 magpspplra gvgrrllgva hpdlrpclcg elqveggpgp vpgmlrtcyv rspwrrgpss
       61 argeqsgsgh leqeevqsgs llfrlllfls rspasrnqri lytvlecqpl fdssdmtiae
      121 wvclaqtikr hyeqyhgfvv ihgtdtmafa asmlsfmlen lqktviltga qvpihalwsd
      181 grenllgall magqyvipev clffqnqlfr gnratkvdar rfaafcspnl lplatvgadi
      241 tinrelvrkv dgkaglvvhs smeqdvgllr lypgipaalv raflqpplkg vvmetfgsgn
      301 gptkpdllqe lrvaterglv ivncthclqg avttdyaagm amagagvisg fdmtseaala
      361 klsyvlgqpg lsldvrkell tkdlrgemtp psveerrpsl qgntlgggvs wllslsgsqe
      421 adalrnalvp slacaaahag dvealqalve lgsdlglvdf ngqtplhaaa rgghteavtm
      481 llqrgvdvnt rdtdgfspll lavrgrtrlt arpqpvsqpr saarlpeaac lallclsgtp
      541 lsgcpaptpt qgqsagliqc plrlaeevtt gcdqrlgvqw grsahasgch wvaagsrglp
      601 vhpgaggsrd gavqaeaagn lavvaflqsl egavgaqapc pepscfqevl pgv
//
LOCUS       XP_016876756             647 aa            linear   PRI 05-AUG-2025
DEFINITION  60 kDa lysophospholipase isoform X3 [Homo sapiens].
ACCESSION   XP_016876756
VERSION     XP_016876756.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021267.2
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 24% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..647
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..647
                     /product="60 kDa lysophospholipase isoform X3"
                     /calculated_mol_wt=68090
     Region          102..389
                     /region_name="L-asparaginase_like"
                     /note="Bacterial L-asparaginases and related enzymes;
                     cl00216"
                     /db_xref="CDD:469665"
     Site            order(109,112..118,120..121,145..146,149,171..172,
                     216..221,265..275,277..278,281,284..285,294,296..298,302,
                     326,329..333,336,355,359,363)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:199207"
     Region          <435..>504
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          461..492
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     CDS             1..647
                     /gene="ASPG"
                     /gene_synonym="C14orf76; GPA/WT; hASNase1; LYSOLP"
                     /coded_by="XM_017021267.2:469..2412"
                     /db_xref="GeneID:374569"
                     /db_xref="HGNC:HGNC:20123"
                     /db_xref="MIM:618472"
ORIGIN      
        1 magpspplra gvgrrllgva hpdlrpclcg elqveggpgp vpgmlrtcyv rspwrrgpss
       61 argeqsgsgh leqeevqsgs llfrlllfls rspasrnqri lytvlecqpl fdssdmtiae
      121 wvclaqtikr hyeqyhgfvv ihgtdtmafa asmlsfmlen lqktviltga qvpihalwsd
      181 grenllgall magqyvipev clffqnqlfr gnratkvdar rfaafcspnl lplatvgadi
      241 tinrelvrkv dgkaglvvhs smeqdvgllr lypgipaalv raflqpplkg vvmetfgsgn
      301 gptkpdllqe lrvaterglv ivncthclqg avttdyaagm amagagvisg fdmtseaala
      361 klsyvlgqpg lsldvrkell tkdlrgemtp psveerrpsl qgntlgggvs wllslsgsqe
      421 adalrnalvp slacaaahag dvealqalve lgsdlglvdf ngqtplhaaa rgghteavtm
      481 llqrgvdvnt rdtdgfspll lavrgrtrlt arpqpvsqpr saarlpeaac lallclsgtp
      541 lsgcpaptpt qgqsagliqc plrlaeevtt gcdqrlgvqw grsahasgch wvaagsrglp
      601 vhpgaggsrd gavqaeaagn lavvaflqsl egavgaqapc pevlpgv
//
LOCUS       XP_016876757             642 aa            linear   PRI 05-AUG-2025
DEFINITION  60 kDa lysophospholipase isoform X4 [Homo sapiens].
ACCESSION   XP_016876757
VERSION     XP_016876757.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021268.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..642
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..642
                     /product="60 kDa lysophospholipase isoform X4"
                     /calculated_mol_wt=67559
     Region          9..361
                     /region_name="L-asparaginase_like"
                     /note="Bacterial L-asparaginases and related enzymes;
                     cl00216"
                     /db_xref="CDD:469665"
     Site            order(18..19,85..86,115..117,142,188)
                     /site_type="active"
                     /db_xref="CDD:199207"
     Site            order(19,28..30,81,84..90,92..93,117..118,121,143..144,
                     188..193,237..247,249..250,253,256..257,266,268..270,274,
                     298,301..305,308,327,331,335)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:199207"
     Region          <407..>476
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          433..464
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     CDS             1..642
                     /gene="ASPG"
                     /gene_synonym="C14orf76; GPA/WT; hASNase1; LYSOLP"
                     /coded_by="XM_017021268.2:72..2000"
                     /db_xref="GeneID:374569"
                     /db_xref="HGNC:HGNC:20123"
                     /db_xref="MIM:618472"
ORIGIN      
        1 maravgperr llavytggti gmrselgvlv pgtglaailr tlpmfhdeeh ararglsedt
       61 lvlppasrnq rilytvlecq plfdssdmti aewvclaqti krhyeqyhgf vvihgtdtma
      121 faasmlsfml enlqktvilt gaqvpihalw sdgrenllga llmagqyvip evclffqnql
      181 frgnratkvd arrfaafcsp nllplatvga ditinrelvr kvdgkaglvv hssmeqdvgl
      241 lrlypgipaa lvraflqppl kgvvmetfgs gngptkpdll qelrvaterg lvivncthcl
      301 qgavttdyaa gmamagagvi sgfdmtseaa laklsyvlgq pglsldvrke lltkdlrgem
      361 tppsveerrp slqgntlggg vswllslsgs qeadalrnal vpslacaaah agdvealqal
      421 velgsdlglv dfngqtplha aargghteav tmllqrgvdv ntrdtdgfsp lllavrgrtr
      481 ltarpqpvsq prsaarlpea aclallclsg tplsgcpapt ptqgqsagli qcplrlaeev
      541 ttgcdqrlgv qwgrsahasg chwvaagsrg lpvhpgaggs rdgavqpesl pptpclvpgd
      601 lalppvpslg cprpgrlrgt qkgeseagdl grvqvvagvg vl
//
LOCUS       XP_016876758             638 aa            linear   PRI 05-AUG-2025
DEFINITION  60 kDa lysophospholipase isoform X5 [Homo sapiens].
ACCESSION   XP_016876758
VERSION     XP_016876758.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021269.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..638
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..638
                     /product="60 kDa lysophospholipase isoform X5"
                     /calculated_mol_wt=67367
     Region          102..389
                     /region_name="L-asparaginase_like"
                     /note="Bacterial L-asparaginases and related enzymes;
                     cl00216"
                     /db_xref="CDD:469665"
     Site            order(109,112..118,120..121,145..146,149,171..172,
                     216..221,265..275,277..278,281,284..285,294,296..298,302,
                     326,329..333,336,355,359,363)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:199207"
     Region          <409..>472
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          429..460
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     CDS             1..638
                     /gene="ASPG"
                     /gene_synonym="C14orf76; GPA/WT; hASNase1; LYSOLP"
                     /coded_by="XM_017021269.1:469..2385"
                     /db_xref="GeneID:374569"
                     /db_xref="HGNC:HGNC:20123"
                     /db_xref="MIM:618472"
ORIGIN      
        1 magpspplra gvgrrllgva hpdlrpclcg elqveggpgp vpgmlrtcyv rspwrrgpss
       61 argeqsgsgh leqeevqsgs llfrlllfls rspasrnqri lytvlecqpl fdssdmtiae
      121 wvclaqtikr hyeqyhgfvv ihgtdtmafa asmlsfmlen lqktviltga qvpihalwsd
      181 grenllgall magqyvipev clffqnqlfr gnratkvdar rfaafcspnl lplatvgadi
      241 tinrelvrkv dgkaglvvhs smeqdvgllr lypgipaalv raflqpplkg vvmetfgsgn
      301 gptkpdllqe lrvaterglv ivncthclqg avttdyaagm amagagvisg fdmtseaala
      361 klsyvlgqpg lsldvrkell tkdlrgemtp psveerrpsl qgntlgggvs wllslsgsqg
      421 sdlglvdfng qtplhaaarg ghteavtmll qrgvdvntrd tdgfspllla vrgrtrltar
      481 pqpvsqprsa arlpeaacla llclsgtpls gcpaptptqg qsagliqcpl rlaeevttgc
      541 dqrlgvqwgr sahasgchwv aagsrglpvh pgaggsrdga vqpeslpptp clvpgdlalp
      601 pvpslgcprp grlrgtqkge seagdlgrvq vvagvgvl
//
LOCUS       XP_047287311             632 aa            linear   PRI 05-AUG-2025
DEFINITION  60 kDa lysophospholipase isoform X6 [Homo sapiens].
ACCESSION   XP_047287311
VERSION     XP_047287311.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431355.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..632
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..632
                     /product="60 kDa lysophospholipase isoform X6"
                     /calculated_mol_wt=66715
     Region          102..389
                     /region_name="L-asparaginase_like"
                     /note="Bacterial L-asparaginases and related enzymes;
                     cl00216"
                     /db_xref="CDD:469665"
     Site            order(109,112..118,120..121,145..146,149,171..172,
                     216..221,265..275,277..278,281,284..285,294,296..298,302,
                     326,329..333,336,355,359,363)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:199207"
     Region          <435..>504
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          461..492
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     CDS             1..632
                     /gene="ASPG"
                     /gene_synonym="C14orf76; GPA/WT; hASNase1; LYSOLP"
                     /coded_by="XM_047431355.1:469..2367"
                     /db_xref="GeneID:374569"
                     /db_xref="HGNC:HGNC:20123"
                     /db_xref="MIM:618472"
ORIGIN      
        1 magpspplra gvgrrllgva hpdlrpclcg elqveggpgp vpgmlrtcyv rspwrrgpss
       61 argeqsgsgh leqeevqsgs llfrlllfls rspasrnqri lytvlecqpl fdssdmtiae
      121 wvclaqtikr hyeqyhgfvv ihgtdtmafa asmlsfmlen lqktviltga qvpihalwsd
      181 grenllgall magqyvipev clffqnqlfr gnratkvdar rfaafcspnl lplatvgadi
      241 tinrelvrkv dgkaglvvhs smeqdvgllr lypgipaalv raflqpplkg vvmetfgsgn
      301 gptkpdllqe lrvaterglv ivncthclqg avttdyaagm amagagvisg fdmtseaala
      361 klsyvlgqpg lsldvrkell tkdlrgemtp psveerrpsl qgntlgggvs wllslsgsqe
      421 adalrnalvp slacaaahag dvealqalve lgsdlglvdf ngqtplhaaa rgghteavtm
      481 llqrgvdvnt rdtdgfspll lavrgrtrlt arpqpvsqpr saarlpeaac lallclsgtp
      541 lsgcpaptpt qgqsagliqc plrlaeevtt gcdqrlgvqw grsahasgch wvaagsrglp
      601 vhpgaggsrd gavqagiqgr prrpagvvag rg
//
LOCUS       XP_016876759             623 aa            linear   PRI 05-AUG-2025
DEFINITION  60 kDa lysophospholipase isoform X7 [Homo sapiens].
ACCESSION   XP_016876759
VERSION     XP_016876759.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021270.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..623
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..623
                     /product="60 kDa lysophospholipase isoform X7"
                     /calculated_mol_wt=65680
     Region          102..389
                     /region_name="L-asparaginase_like"
                     /note="Bacterial L-asparaginases and related enzymes;
                     cl00216"
                     /db_xref="CDD:469665"
     Site            order(109,112..118,120..121,145..146,149,171..172,
                     216..221,265..275,277..278,281,284..285,294,296..298,302,
                     326,329..333,336,355,359,363)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:199207"
     Region          <435..>504
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          461..492
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     CDS             1..623
                     /gene="ASPG"
                     /gene_synonym="C14orf76; GPA/WT; hASNase1; LYSOLP"
                     /coded_by="XM_017021270.1:469..2340"
                     /db_xref="GeneID:374569"
                     /db_xref="HGNC:HGNC:20123"
                     /db_xref="MIM:618472"
ORIGIN      
        1 magpspplra gvgrrllgva hpdlrpclcg elqveggpgp vpgmlrtcyv rspwrrgpss
       61 argeqsgsgh leqeevqsgs llfrlllfls rspasrnqri lytvlecqpl fdssdmtiae
      121 wvclaqtikr hyeqyhgfvv ihgtdtmafa asmlsfmlen lqktviltga qvpihalwsd
      181 grenllgall magqyvipev clffqnqlfr gnratkvdar rfaafcspnl lplatvgadi
      241 tinrelvrkv dgkaglvvhs smeqdvgllr lypgipaalv raflqpplkg vvmetfgsgn
      301 gptkpdllqe lrvaterglv ivncthclqg avttdyaagm amagagvisg fdmtseaala
      361 klsyvlgqpg lsldvrkell tkdlrgemtp psveerrpsl qgntlgggvs wllslsgsqe
      421 adalrnalvp slacaaahag dvealqalve lgsdlglvdf ngqtplhaaa rgghteavtm
      481 llqrgvdvnt rdtdgfspll lavrgrtrlt arpqpvsqpr saarlpeaac lallclsgas
      541 gchwvaagsr glpvhpgagg srdgavqpes lpptpclvpg dlalppvpsl gcprpgrlrg
      601 tqkgeseagd lgrvqvvagv gvl
//
LOCUS       XP_016876760             609 aa            linear   PRI 05-AUG-2025
DEFINITION  60 kDa lysophospholipase isoform X8 [Homo sapiens].
ACCESSION   XP_016876760
VERSION     XP_016876760.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021271.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..609
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..609
                     /product="60 kDa lysophospholipase isoform X8"
                     /calculated_mol_wt=65308
     Region          102..389
                     /region_name="L-asparaginase_like"
                     /note="Bacterial L-asparaginases and related enzymes;
                     cl00216"
                     /db_xref="CDD:469665"
     Site            order(109,112..118,120..121,145..146,149,171..172,
                     216..221,265..275,277..278,281,284..285,294,296..298,302,
                     326,329..333,336,355,359,363)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:199207"
     Region          <435..>524
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Site            order(438..440,442..443,447,450,459,461,463,467..468,
                     471..473,475..476,480,483,492,494,496,500..501,504..506,
                     508..509,513,516)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          461..492
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          494..524
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     CDS             1..609
                     /gene="ASPG"
                     /gene_synonym="C14orf76; GPA/WT; hASNase1; LYSOLP"
                     /coded_by="XM_017021271.1:469..2298"
                     /db_xref="GeneID:374569"
                     /db_xref="HGNC:HGNC:20123"
                     /db_xref="MIM:618472"
ORIGIN      
        1 magpspplra gvgrrllgva hpdlrpclcg elqveggpgp vpgmlrtcyv rspwrrgpss
       61 argeqsgsgh leqeevqsgs llfrlllfls rspasrnqri lytvlecqpl fdssdmtiae
      121 wvclaqtikr hyeqyhgfvv ihgtdtmafa asmlsfmlen lqktviltga qvpihalwsd
      181 grenllgall magqyvipev clffqnqlfr gnratkvdar rfaafcspnl lplatvgadi
      241 tinrelvrkv dgkaglvvhs smeqdvgllr lypgipaalv raflqpplkg vvmetfgsgn
      301 gptkpdllqe lrvaterglv ivncthclqg avttdyaagm amagagvisg fdmtseaala
      361 klsyvlgqpg lsldvrkell tkdlrgemtp psveerrpsl qgntlgggvs wllslsgsqe
      421 adalrnalvp slacaaahag dvealqalve lgsdlglvdf ngqtplhaaa rgghteavtm
      481 llqrgvdvnt rdtdgfspll lavrgrhpgv igllreagas lstqeleeag telcsqnrcp
      541 pphalclvtw rcllcpawaa rgqddsegpk kesrrqetwa gcrwwlgwgc cewwglcack
      601 srvpglgsg
//
LOCUS       XP_016876761             607 aa            linear   PRI 05-AUG-2025
DEFINITION  60 kDa lysophospholipase isoform X9 [Homo sapiens].
ACCESSION   XP_016876761
VERSION     XP_016876761.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021272.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..607
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..607
                     /product="60 kDa lysophospholipase isoform X9"
                     /calculated_mol_wt=64436
     Region          102..389
                     /region_name="L-asparaginase_like"
                     /note="Bacterial L-asparaginases and related enzymes;
                     cl00216"
                     /db_xref="CDD:469665"
     Site            order(109,112..118,120..121,145..146,149,171..172,
                     216..221,265..275,277..278,281,284..285,294,296..298,302,
                     326,329..333,336,355,359,363)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:199207"
     Region          <412..592
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Site            order(438..440,442..443,447,450,459,461,463,467..468,
                     471..473,475..476,480,483,492,494,496,500..501,504..506,
                     508..509,513,516)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          461..492
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          494..524
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          561..591
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     CDS             1..607
                     /gene="ASPG"
                     /gene_synonym="C14orf76; GPA/WT; hASNase1; LYSOLP"
                     /coded_by="XM_017021272.2:469..2292"
                     /db_xref="GeneID:374569"
                     /db_xref="HGNC:HGNC:20123"
                     /db_xref="MIM:618472"
ORIGIN      
        1 magpspplra gvgrrllgva hpdlrpclcg elqveggpgp vpgmlrtcyv rspwrrgpss
       61 argeqsgsgh leqeevqsgs llfrlllfls rspasrnqri lytvlecqpl fdssdmtiae
      121 wvclaqtikr hyeqyhgfvv ihgtdtmafa asmlsfmlen lqktviltga qvpihalwsd
      181 grenllgall magqyvipev clffqnqlfr gnratkvdar rfaafcspnl lplatvgadi
      241 tinrelvrkv dgkaglvvhs smeqdvgllr lypgipaalv raflqpplkg vvmetfgsgn
      301 gptkpdllqe lrvaterglv ivncthclqg avttdyaagm amagagvisg fdmtseaala
      361 klsyvlgqpg lsldvrkell tkdlrgemtp psveerrpsl qgntlgggvs wllslsgsqe
      421 adalrnalvp slacaaahag dvealqalve lgsdlglvdf ngqtplhaaa rgghteavtm
      481 llqrgvdvnt rdtdgfspll lavrgrhpgv igllreagas lstqeleeag telcrlayra
      541 dleglqvwwq agadlgqpgy dghsalhvae aagnlavvaf lqslegavga qapcpepscf
      601 qevlpgv
//
LOCUS       XP_016876762             601 aa            linear   PRI 05-AUG-2025
DEFINITION  60 kDa lysophospholipase isoform X10 [Homo sapiens].
ACCESSION   XP_016876762
VERSION     XP_016876762.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021273.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..601
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..601
                     /product="60 kDa lysophospholipase isoform X10"
                     /calculated_mol_wt=63744
     Region          102..389
                     /region_name="L-asparaginase_like"
                     /note="Bacterial L-asparaginases and related enzymes;
                     cl00216"
                     /db_xref="CDD:469665"
     Site            order(109,112..118,120..121,145..146,149,171..172,
                     216..221,265..275,277..278,281,284..285,294,296..298,302,
                     326,329..333,336,355,359,363)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:199207"
     Region          <412..592
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Site            order(438..440,442..443,447,450,459,461,463,467..468,
                     471..473,475..476,480,483,492,494,496,500..501,504..506,
                     508..509,513,516)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          461..492
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          494..524
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          561..591
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     CDS             1..601
                     /gene="ASPG"
                     /gene_synonym="C14orf76; GPA/WT; hASNase1; LYSOLP"
                     /coded_by="XM_017021273.2:469..2274"
                     /db_xref="GeneID:374569"
                     /db_xref="HGNC:HGNC:20123"
                     /db_xref="MIM:618472"
ORIGIN      
        1 magpspplra gvgrrllgva hpdlrpclcg elqveggpgp vpgmlrtcyv rspwrrgpss
       61 argeqsgsgh leqeevqsgs llfrlllfls rspasrnqri lytvlecqpl fdssdmtiae
      121 wvclaqtikr hyeqyhgfvv ihgtdtmafa asmlsfmlen lqktviltga qvpihalwsd
      181 grenllgall magqyvipev clffqnqlfr gnratkvdar rfaafcspnl lplatvgadi
      241 tinrelvrkv dgkaglvvhs smeqdvgllr lypgipaalv raflqpplkg vvmetfgsgn
      301 gptkpdllqe lrvaterglv ivncthclqg avttdyaagm amagagvisg fdmtseaala
      361 klsyvlgqpg lsldvrkell tkdlrgemtp psveerrpsl qgntlgggvs wllslsgsqe
      421 adalrnalvp slacaaahag dvealqalve lgsdlglvdf ngqtplhaaa rgghteavtm
      481 llqrgvdvnt rdtdgfspll lavrgrhpgv igllreagas lstqeleeag telcrlayra
      541 dleglqvwwq agadlgqpgy dghsalhvae aagnlavvaf lqslegavga qapcpevlpg
      601 v
//
LOCUS       XP_016876763             599 aa            linear   PRI 05-AUG-2025
DEFINITION  60 kDa lysophospholipase isoform X11 [Homo sapiens].
ACCESSION   XP_016876763
VERSION     XP_016876763.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021274.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..599
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..599
                     /product="60 kDa lysophospholipase isoform X11"
                     /calculated_mol_wt=63142
     Region          31..318
                     /region_name="L-asparaginase_like"
                     /note="Bacterial L-asparaginases and related enzymes;
                     cl00216"
                     /db_xref="CDD:469665"
     Site            order(38,41..47,49..50,74..75,78,100..101,145..150,
                     194..204,206..207,210,213..214,223,225..227,231,255,
                     258..262,265,284,288,292)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:199207"
     Region          <364..>433
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          390..421
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     CDS             1..599
                     /gene="ASPG"
                     /gene_synonym="C14orf76; GPA/WT; hASNase1; LYSOLP"
                     /coded_by="XM_017021274.2:560..2359"
                     /db_xref="GeneID:374569"
                     /db_xref="HGNC:HGNC:20123"
                     /db_xref="MIM:618472"
ORIGIN      
        1 mfhdeehara rglsedtlvl ppasrnqril ytvlecqplf dssdmtiaew vclaqtikrh
       61 yeqyhgfvvi hgtdtmafaa smlsfmlenl qktviltgaq vpihalwsdg renllgallm
      121 agqyvipevc lffqnqlfrg nratkvdarr faafcspnll platvgadit inrelvrkvd
      181 gkaglvvhss meqdvgllrl ypgipaalvr aflqpplkgv vmetfgsgng ptkpdllqel
      241 rvaterglvi vncthclqga vttdyaagma magagvisgf dmtseaalak lsyvlgqpgl
      301 sldvrkellt kdlrgemtpp sveerrpslq gntlgggvsw llslsgsqea dalrnalvps
      361 lacaaahagd vealqalvel gsdlglvdfn gqtplhaaar gghteavtml lqrgvdvntr
      421 dtdgfsplll avrgrtrlta rpqpvsqprs aarlpeaacl allclsgtpl sgcpaptptq
      481 gqsagliqcp lrlaeevttg cdqrlgvqwg rsahasgchw vaagsrglpv hpgaggsrdg
      541 avqpeslppt pclvpgdlal ppvpslgcpr pgrlrgtqkg eseagdlgrv qvvagvgvl
//
LOCUS       XP_016876764             589 aa            linear   PRI 05-AUG-2025
DEFINITION  60 kDa lysophospholipase isoform X12 [Homo sapiens].
ACCESSION   XP_016876764
VERSION     XP_016876764.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021275.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..589
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..589
                     /product="60 kDa lysophospholipase isoform X12"
                     /calculated_mol_wt=63468
     Region          102..389
                     /region_name="L-asparaginase_like"
                     /note="Bacterial L-asparaginases and related enzymes;
                     cl00216"
                     /db_xref="CDD:469665"
     Site            order(109,112..118,120..121,145..146,149,171..172,
                     216..221,265..275,277..278,281,284..285,294,296..298,302,
                     326,329..333,336,355,359,363)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:199207"
     Region          <435..>524
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Site            order(438..440,442..443,447,450,459,461,463,467..468,
                     471..473,475..476,480,483,492,494,496,500..501,504..506,
                     508..509,513,516)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          461..492
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          494..524
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     CDS             1..589
                     /gene="ASPG"
                     /gene_synonym="C14orf76; GPA/WT; hASNase1; LYSOLP"
                     /coded_by="XM_017021275.2:469..2238"
                     /db_xref="GeneID:374569"
                     /db_xref="HGNC:HGNC:20123"
                     /db_xref="MIM:618472"
ORIGIN      
        1 magpspplra gvgrrllgva hpdlrpclcg elqveggpgp vpgmlrtcyv rspwrrgpss
       61 argeqsgsgh leqeevqsgs llfrlllfls rspasrnqri lytvlecqpl fdssdmtiae
      121 wvclaqtikr hyeqyhgfvv ihgtdtmafa asmlsfmlen lqktviltga qvpihalwsd
      181 grenllgall magqyvipev clffqnqlfr gnratkvdar rfaafcspnl lplatvgadi
      241 tinrelvrkv dgkaglvvhs smeqdvgllr lypgipaalv raflqpplkg vvmetfgsgn
      301 gptkpdllqe lrvaterglv ivncthclqg avttdyaagm amagagvisg fdmtseaala
      361 klsyvlgqpg lsldvrkell tkdlrgemtp psveerrpsl qgntlgggvs wllslsgsqe
      421 adalrnalvp slacaaahag dvealqalve lgsdlglvdf ngqtplhaaa rgghteavtm
      481 llqrgvdvnt rdtdgfspll lavrgrhpgv igllreagas lstqeleeag telcrqrqpg
      541 twqwwpfyra wrvrlvprph aqsphvfrkc clvsnlkasc csishsflp
//
LOCUS       XP_016876765             583 aa            linear   PRI 05-AUG-2025
DEFINITION  60 kDa lysophospholipase isoform X13 [Homo sapiens].
ACCESSION   XP_016876765
VERSION     XP_016876765.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021276.2
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 26% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..583
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..583
                     /product="60 kDa lysophospholipase isoform X13"
                     /calculated_mol_wt=62745
     Region          102..389
                     /region_name="L-asparaginase_like"
                     /note="Bacterial L-asparaginases and related enzymes;
                     cl00216"
                     /db_xref="CDD:469665"
     Site            order(109,112..118,120..121,145..146,149,171..172,
                     216..221,265..275,277..278,281,284..285,294,296..298,302,
                     326,329..333,336,355,359,363)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:199207"
     Region          <435..>524
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Site            order(438..440,442..443,447,450,459,461,463,467..468,
                     471..473,475..476,480,483,492,494,496,500..501,504..506,
                     508..509,513,516)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          461..492
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          494..524
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     CDS             1..583
                     /gene="ASPG"
                     /gene_synonym="C14orf76; GPA/WT; hASNase1; LYSOLP"
                     /coded_by="XM_017021276.2:469..2220"
                     /db_xref="GeneID:374569"
                     /db_xref="HGNC:HGNC:20123"
                     /db_xref="MIM:618472"
ORIGIN      
        1 magpspplra gvgrrllgva hpdlrpclcg elqveggpgp vpgmlrtcyv rspwrrgpss
       61 argeqsgsgh leqeevqsgs llfrlllfls rspasrnqri lytvlecqpl fdssdmtiae
      121 wvclaqtikr hyeqyhgfvv ihgtdtmafa asmlsfmlen lqktviltga qvpihalwsd
      181 grenllgall magqyvipev clffqnqlfr gnratkvdar rfaafcspnl lplatvgadi
      241 tinrelvrkv dgkaglvvhs smeqdvgllr lypgipaalv raflqpplkg vvmetfgsgn
      301 gptkpdllqe lrvaterglv ivncthclqg avttdyaagm amagagvisg fdmtseaala
      361 klsyvlgqpg lsldvrkell tkdlrgemtp psveerrpsl qgntlgggvs wllslsgsqe
      421 adalrnalvp slacaaahag dvealqalve lgsdlglvdf ngqtplhaaa rgghteavtm
      481 llqrgvdvnt rdtdgfspll lavrgrhpgv igllreagas lstqeleeag telcrqrqpg
      541 twqwwpfyra wrvrlvprph aqkcclvsnl kasccsishs flp
//
LOCUS       XP_005267647             579 aa            linear   PRI 05-AUG-2025
DEFINITION  60 kDa lysophospholipase isoform X14 [Homo sapiens].
ACCESSION   XP_005267647
VERSION     XP_005267647.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267590.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..579
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..579
                     /product="60 kDa lysophospholipase isoform X14"
                     /calculated_mol_wt=61444
     Region          9..361
                     /region_name="L-asparaginase_like"
                     /note="Bacterial L-asparaginases and related enzymes;
                     cl00216"
                     /db_xref="CDD:469665"
     Site            order(18..19,85..86,115..117,142,188)
                     /site_type="active"
                     /db_xref="CDD:199207"
     Site            order(19,28..30,81,84..90,92..93,117..118,121,143..144,
                     188..193,237..247,249..250,253,256..257,266,268..270,274,
                     298,301..305,308,327,331,335)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:199207"
     Region          <384..564
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Site            order(410..412,414..415,419,422,431,433,435,439..440,
                     443..445,447..448,452,455,464,466,468,472..473,476..478,
                     480..481,485,488)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          433..464
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          466..496
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          533..563
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     CDS             1..579
                     /gene="ASPG"
                     /gene_synonym="C14orf76; GPA/WT; hASNase1; LYSOLP"
                     /coded_by="XM_005267590.5:72..1811"
                     /db_xref="GeneID:374569"
                     /db_xref="HGNC:HGNC:20123"
                     /db_xref="MIM:618472"
ORIGIN      
        1 maravgperr llavytggti gmrselgvlv pgtglaailr tlpmfhdeeh ararglsedt
       61 lvlppasrnq rilytvlecq plfdssdmti aewvclaqti krhyeqyhgf vvihgtdtma
      121 faasmlsfml enlqktvilt gaqvpihalw sdgrenllga llmagqyvip evclffqnql
      181 frgnratkvd arrfaafcsp nllplatvga ditinrelvr kvdgkaglvv hssmeqdvgl
      241 lrlypgipaa lvraflqppl kgvvmetfgs gngptkpdll qelrvaterg lvivncthcl
      301 qgavttdyaa gmamagagvi sgfdmtseaa laklsyvlgq pglsldvrke lltkdlrgem
      361 tppsveerrp slqgntlggg vswllslsgs qeadalrnal vpslacaaah agdvealqal
      421 velgsdlglv dfngqtplha aargghteav tmllqrgvdv ntrdtdgfsp lllavrgrhp
      481 gvigllreag aslstqelee agtelcrlay radleglqvw wqagadlgqp gydghsalhv
      541 aeaagnlavv aflqslegav gaqapcpeps cfqevlpgv
//
LOCUS       XP_047287312             572 aa            linear   PRI 05-AUG-2025
DEFINITION  60 kDa lysophospholipase isoform X15 [Homo sapiens].
ACCESSION   XP_047287312
VERSION     XP_047287312.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431356.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 27% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..572
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..572
                     /product="60 kDa lysophospholipase isoform X15"
                     /calculated_mol_wt=60226
     Region          9..361
                     /region_name="L-asparaginase_like"
                     /note="Bacterial L-asparaginases and related enzymes;
                     cl00216"
                     /db_xref="CDD:469665"
     Site            order(18..19,85..86,115..117,142,188)
                     /site_type="active"
                     /db_xref="CDD:199207"
     Site            order(19,28..30,81,84..90,92..93,117..118,121,143..144,
                     188..193,237..247,249..250,253,256..257,266,268..270,274,
                     298,301..305,308,327,331,335)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:199207"
     Region          <407..>476
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          433..464
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     CDS             1..572
                     /gene="ASPG"
                     /gene_synonym="C14orf76; GPA/WT; hASNase1; LYSOLP"
                     /coded_by="XM_047431356.1:72..1790"
                     /db_xref="GeneID:374569"
                     /db_xref="HGNC:HGNC:20123"
                     /db_xref="MIM:618472"
ORIGIN      
        1 maravgperr llavytggti gmrselgvlv pgtglaailr tlpmfhdeeh ararglsedt
       61 lvlppasrnq rilytvlecq plfdssdmti aewvclaqti krhyeqyhgf vvihgtdtma
      121 faasmlsfml enlqktvilt gaqvpihalw sdgrenllga llmagqyvip evclffqnql
      181 frgnratkvd arrfaafcsp nllplatvga ditinrelvr kvdgkaglvv hssmeqdvgl
      241 lrlypgipaa lvraflqppl kgvvmetfgs gngptkpdll qelrvaterg lvivncthcl
      301 qgavttdyaa gmamagagvi sgfdmtseaa laklsyvlgq pglsldvrke lltkdlrgem
      361 tppsveerrp slqgntlggg vswllslsgs qeadalrnal vpslacaaah agdvealqal
      421 velgsdlglv dfngqtplha aargghteav tmllqrgvdv ntrdtdgfsp lllavrgrtr
      481 ltarpqpvsq prsaarlpea aclallclsg asgchwvaag srglpvhpga ggsrdgavqa
      541 eaagnlavva flqslegavg aqapcpevlp gv
//
LOCUS       XP_024305345             162 aa            linear   PRI 05-AUG-2025
DEFINITION  ras-related protein Rab-15 isoform X1 [Homo sapiens].
ACCESSION   XP_024305345
VERSION     XP_024305345.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449577.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..162
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..162
                     /product="ras-related protein Rab-15 isoform X1"
                     /calculated_mol_wt=18228
     Region          <1..126
                     /region_name="P-loop containing Nucleoside Triphosphate
                     Hydrolases"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; cl38936"
                     /db_xref="CDD:476819"
     Site            17..20
                     /site_type="other"
                     /note="G3 box"
                     /db_xref="CDD:206698"
     Site            order(19..20,36..37)
                     /site_type="other"
                     /note="Switch II region"
                     /db_xref="CDD:206698"
     Site            74..77
                     /site_type="other"
                     /note="G4 box"
                     /db_xref="CDD:206698"
     Site            105..107
                     /site_type="other"
                     /note="G5 box"
                     /db_xref="CDD:206698"
     CDS             1..162
                     /gene="RAB15"
                     /coded_by="XM_024449577.2:43..531"
                     /db_xref="GeneID:376267"
                     /db_xref="HGNC:HGNC:20150"
                     /db_xref="MIM:619547"
ORIGIN      
        1 mktievdgik vriqiwdtag qeryqtitkq yyrraqgifl vydissersy qhimkwvsdv
       61 devgdatslp gcgegaspgk arrgpdgkan asrklclpqp wmktsgthqk asrrsllgir
      121 lmrsrngrwe eskgsswrrs mawtsmkqvp aptstlkshs rv
//
LOCUS       XP_011535044             160 aa            linear   PRI 05-AUG-2025
DEFINITION  TOMM20-like protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_011535044
VERSION     XP_011535044.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536742.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..160
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..160
                     /product="TOMM20-like protein 1 isoform X1"
                     /calculated_mol_wt=18489
     Region          24..135
                     /region_name="MAS20"
                     /note="MAS20 protein import receptor; pfam02064"
                     /db_xref="CDD:460434"
     CDS             1..160
                     /gene="TOMM20L"
                     /gene_synonym="UNQ9438"
                     /coded_by="XM_011536742.4:29..511"
                     /db_xref="GeneID:387990"
                     /db_xref="HGNC:HGNC:33752"
ORIGIN      
        1 mpsvrsllrl laaaaacgaf aflgyciyln rkrrgdpafk rrlrdkrrae pqkaeeqgtq
       61 vqcfrsaqlw dptknkklqe lflqevrmge lwlsrgehrm giqhlgnall vceqprellk
      121 vfkhtlppkv femllhkipl icqqfeadmn eqdcleddpd
//
LOCUS       XP_011535045             143 aa            linear   PRI 05-AUG-2025
DEFINITION  TOMM20-like protein 1 isoform X2 [Homo sapiens].
ACCESSION   XP_011535045
VERSION     XP_011535045.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536743.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..143
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..143
                     /product="TOMM20-like protein 1 isoform X2"
                     /calculated_mol_wt=16493
     Region          24..135
                     /region_name="MAS20"
                     /note="MAS20 protein import receptor; pfam02064"
                     /db_xref="CDD:460434"
     CDS             1..143
                     /gene="TOMM20L"
                     /gene_synonym="UNQ9438"
                     /coded_by="XM_011536743.3:29..460"
                     /db_xref="GeneID:387990"
                     /db_xref="HGNC:HGNC:33752"
ORIGIN      
        1 mpsvrsllrl laaaaacgaf aflgyciyln rkrrgdpafk rrlrdkrrae pqkaeeqgtq
       61 vqcfrsaqlw dptknkklqe lflqevrmge lwlsrgehrm giqhlgnall vceqprellk
      121 vfkhtlppkv femllhkipl icq
//
LOCUS       XP_011535046             110 aa            linear   PRI 05-AUG-2025
DEFINITION  TOMM20-like protein 1 isoform X3 [Homo sapiens].
ACCESSION   XP_011535046
VERSION     XP_011535046.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536744.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..110
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..110
                     /product="TOMM20-like protein 1 isoform X3"
                     /calculated_mol_wt=12589
     Region          24..85
                     /region_name="MAS20"
                     /note="MAS20 protein import receptor; cl03428"
                     /db_xref="CDD:470806"
     CDS             1..110
                     /gene="TOMM20L"
                     /gene_synonym="UNQ9438"
                     /coded_by="XM_011536744.4:29..361"
                     /db_xref="GeneID:387990"
                     /db_xref="HGNC:HGNC:33752"
ORIGIN      
        1 mpsvrsllrl laaaaacgaf aflgyciyln rkrrgdpafk rrlrdrehrm giqhlgnall
       61 vceqprellk vfkhtlppkv femllhkipl icqqfeadmn eqdcleddpd
//
LOCUS       XP_024305346             194 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 179 isoform X1 [Homo sapiens].
ACCESSION   XP_024305346
VERSION     XP_024305346.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449578.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..194
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..194
                     /product="transmembrane protein 179 isoform X1"
                     /calculated_mol_wt=21838
     CDS             1..194
                     /gene="TMEM179"
                     /gene_synonym="C14orf90; TMEM179A"
                     /coded_by="XM_024449578.2:32..616"
                     /db_xref="GeneID:388021"
                     /db_xref="HGNC:HGNC:20137"
                     /db_xref="MIM:621219"
ORIGIN      
        1 malnnflfaq cacyflaflf sfvvvvplse nghdfrgrcl lftegmwlsa nltvqererf
       61 tvqewgppaa crfsllasll slllaaahaw rtlfflckgh egsffsafln llvsafvvfl
      121 vfiastivsv gftmwcdtit ekgtvphsce elqdidlelg vdnsafydqf aiaqrlkvnl
      181 frwleepplf trpp
//
LOCUS       XP_011535047             187 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 179 isoform X2 [Homo sapiens].
ACCESSION   XP_011535047
VERSION     XP_011535047.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536745.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..187
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..187
                     /product="transmembrane protein 179 isoform X2"
                     /calculated_mol_wt=20846
     CDS             1..187
                     /gene="TMEM179"
                     /gene_synonym="C14orf90; TMEM179A"
                     /coded_by="XM_011536745.3:5406..5969"
                     /db_xref="GeneID:388021"
                     /db_xref="HGNC:HGNC:20137"
                     /db_xref="MIM:621219"
ORIGIN      
        1 miavklflwv tslrssvlta crltssllag wglvnnrhll ltlpearglr srlgsssffs
       61 aflnllvsaf vvflvfiast ivsvgftmwc dtitekgtvp hsceelqdid lelgvdnsaf
      121 ydqfaiaqfg lwaswlawla ittlaflkvy hnyrqedlld slihekelll arpsprtsfq
      181 eeksavi
//
LOCUS       XP_011535052             134 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 179 isoform X3 [Homo sapiens].
ACCESSION   XP_011535052
VERSION     XP_011535052.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536750.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..134
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..134
                     /product="transmembrane protein 179 isoform X3"
                     /calculated_mol_wt=15090
     CDS             1..134
                     /gene="TMEM179"
                     /gene_synonym="C14orf90; TMEM179A"
                     /coded_by="XM_011536750.2:229..633"
                     /db_xref="GeneID:388021"
                     /db_xref="HGNC:HGNC:20137"
                     /db_xref="MIM:621219"
ORIGIN      
        1 mkcsffsafl nllvsafvvf lvfiastivs vgftmwcdti tekgtvphsc eelqdidlel
       61 gvdnsafydq faiaqfglwa swlawlaitt laflkvyhny rqedlldsli hekelllarp
      121 sprtsfqeek savi
//
LOCUS       XP_047287317            1298 aa            linear   PRI 05-AUG-2025
DEFINITION  kinectin isoform X1 [Homo sapiens].
ACCESSION   XP_047287317
VERSION     XP_047287317.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431361.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1298
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1298
                     /product="kinectin isoform X1"
                     /calculated_mol_wt=149349
     Region          29..160
                     /region_name="Rib_recp_KP_reg"
                     /note="Ribosome receptor lysine/proline rich region;
                     pfam05104"
                     /db_xref="CDD:461548"
     Region          <326..>584
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          480..1251
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1298
                     /gene="KTN1"
                     /gene_synonym="CG1; KNT; MU-RMS-40.19"
                     /coded_by="XM_047431361.1:303..4199"
                     /db_xref="GeneID:3895"
                     /db_xref="HGNC:HGNC:6467"
                     /db_xref="MIM:600381"
ORIGIN      
        1 mefyesayfi vlipsivitv iflffwlfmk etlydevlak qkreqklipt ktdkkkaekk
       61 knkkkeiqng nlhesdsesv prdfklsdal aveddqvapv plnvvetsss vrerkkkekk
      121 qkpvleeqvi kesdaskipg kkvepvpvtk qptppseaaa skkkpgqkks kngsddqdkk
      181 vetlmvpskr qealplhqet kqesgsgkkk asskkqkten vfvdepliha ttyiplmdna
      241 dsspvvdkre vidllkpdqv egiqksgtkk lktetdkena evkfkdflls lktmmfsede
      301 alcvvdllke ksgviqdalk ksskgelttl ihqlqekdkl laavkedaaa tkdrckqltq
      361 emmtekersn vvitrmkdri gtlekehnvf qnkihvsyqe tqqmqmkfqq vreqmeaeia
      421 hlkqengilr davsnttnql eskqsaelnk lrqdyarlvn eltektgklq qeevqkknae
      481 qaatqlkvql qeaerrweev qsyirkrtae heaaqqdlqs kfvakenevq slhskltdtl
      541 vskqqleqrl mqlmeseqkr vnkeeslqmq vqdileqnea lkaqiqqfhs qiaaqtsasv
      601 laeelhkvia ekdkqikqte dslaserdrl tskeeelkdi qnmnfllkae vqklqalane
      661 qaaaahelek mqqsvyvkdd kirlleeqlq heisnkmeef kilndqnkal ksevqklqtl
      721 vseqpnkdvv eqmekciqek deklktveel letgliqvat keeelnairt enssltkevq
      781 dlkakqndqv sfaslveelk kvihekdgki ksveelleae llkvankekt vqdlkqeika
      841 lkeeignvql ekaqqlsits kvqelqnllk gkeeqmntmk avleekekdl antgkwlqdl
      901 qeeneslkah vqevaqhnlk eassasqfee leivlkeken elkrleamlk eresdlsskt
      961 qllqdvqden klfksqieql kqqnyqqass fppheellkv iserekeisg lwneldslkd
     1021 avehqrkknn sygewlhgfe kkakecmagt sgseevkvle hklkeademh tllqleceky
     1081 ksvlaetegi lqklqrsveq eenkwkvkvd eshktikqmq ssftsseqel erlrsenkdi
     1141 enlrrerehl emelekaeme rstyvtevre lkdlltelqk klddsyseav rqneelnllk
     1201 aqlnetltkl rteqnerqkv agdlhkaqqs leliqskivk aagdttvien sdvspetess
     1261 eketmsvsln qtvtqlqqll qavnqqltke kehyqvle
//
LOCUS       XP_047287326            1026 aa            linear   PRI 05-AUG-2025
DEFINITION  HEAT repeat-containing protein 4 isoform X1 [Homo sapiens].
ACCESSION   XP_047287326
VERSION     XP_047287326.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431370.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1026
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1026
                     /product="HEAT repeat-containing protein 4 isoform X1"
                     /calculated_mol_wt=117045
     Region          530..559
                     /region_name="HEAT"
                     /note="HEAT repeat; pfam02985"
                     /db_xref="CDD:460773"
     Site            order(647..648,651,654..655,658,682..683,686,689..690,693,
                     747..748,751,754..755,781..782,785,788..789)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          666..694
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          680..825
                     /region_name="HEAT"
                     /note="HEAT repeat [General function prediction only];
                     COG1413"
                     /db_xref="CDD:441023"
     Region          729..755
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          764..790
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          796..821
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     CDS             1..1026
                     /gene="HEATR4"
                     /coded_by="XM_047431370.1:227..3307"
                     /db_xref="GeneID:399671"
                     /db_xref="HGNC:HGNC:16761"
ORIGIN      
        1 mtrtqkgktf lphcfyqslp prlgwgmiln ysklkgkeec asvssvpmvf fssqyrlhrk
       61 sqylkmaaan ltfsqevvwq rglpsipysq ysfdhlyntn diihtpqirk arpqkpvsfk
      121 flgssspltg dtslavktes sanpekklkk skpastvrea prplihhpcm hpdmlgrpps
      181 ldvnleerea wllppekear aweatvlekl nertarwiqs krprrpgasp nkwqsflrqq
      241 ydwshirdel tsasdlellk qleaeetaef edqsvilppq ekkkpelllp vyyrlpsyfq
      301 qaetveimpg nkstedihek tslsqpqtqs yfrqvtprag kfaystdntf eqeiyfdevq
      361 iihqigakrd qivlenlnry nkqlskvfpe tpekwsaqai peasyrpvqg alrwtalptp
      421 akdmllqvge kdvpiktrrl kkqakslqed vtwelvvlrr mlkewktawa liiewhhetv
      481 enllqslgdl hddvrikait tcataalerp riatsqrdsd ktiqdlpevl lpaleaalcd
      541 knahvrmaaa icqyaiqshn plarnimqta llkgnsvdsw aaaqclaleg tatypvikri
      601 lhqlftkkne dteeqsyill sylsekttli htmlavelns cqwknrivac qafsrisgnv
      661 cldmkhkliq lmwndwnkev rraaaqalgq mslgkevhdi irvklgqgns qervealyli
      721 gelklmtakl lpsflhcfsd dftavrraac laagalqird kmvlecllnl mqrdpywkik
      781 afairalgqi gqvspeltdl llwaihyees pgvrleacrs ilalklqgdr vrdtfldvll
      841 lenhdavlke myqtmkilnl gnegnqemlq eiknriktls qkdllthkil klemvmgkvr
      901 eeakrvylkp kgeqgpltlq tllqetfqde mvlprrpsev cdteavikpv kprapnpwlq
      961 ssvpglttrs kvrsslvkdl rtspekriav gpfrsdypal ylgkfsertf fspimsspsg
     1021 kkgahl
//
LOCUS       XP_024305350             707 aa            linear   PRI 05-AUG-2025
DEFINITION  HEAT repeat-containing protein 4 isoform X2 [Homo sapiens].
ACCESSION   XP_024305350
VERSION     XP_024305350.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449582.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..707
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..707
                     /product="HEAT repeat-containing protein 4 isoform X2"
                     /calculated_mol_wt=80897
     Region          483..504
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Site            order(496..497,500,503..504,547..548,552..553,556,581,584,
                     587..588,607,647..648,651,654..655,682..683,686,689..690)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          530..559
                     /region_name="HEAT"
                     /note="HEAT repeat; pfam02985"
                     /db_xref="CDD:460773"
     Region          530..556
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          566..608
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          617..655
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          666..691
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     CDS             1..707
                     /gene="HEATR4"
                     /coded_by="XM_024449582.2:1..2124"
                     /db_xref="GeneID:399671"
                     /db_xref="HGNC:HGNC:16761"
ORIGIN      
        1 mtrtqkgktf lphcfyqslp prlgwgmiln ysklkgkeec asvssvpmvf fssqyrlhrk
       61 sqylkmaaan ltfsqevvwq rglpsipysq ysfdhlyntn diihtpqirk arpqkpvsfk
      121 flgssspltg dtslavktes sanpekklkk skpastvrea prplihhpcm hpdmlgrpps
      181 ldvnleerea wllppekear aweatvlekl nertarwiqs krprrpgasp nkwqsflrqq
      241 ydwshirdel tsasdlellk qleaeetaef edqsvilppq ekkkpelllp vyyrlpsyfq
      301 qaetveimpg nkstedihek tslsqpqtqs yfrqvtprag kfaystdntf eqeiyfdevq
      361 iihqigakrd qivlenlnry nkqlskvfpe tpekwsaqai peasyrpvqg alrwtalptp
      421 akdmllqvge kdvpiktrrl kkqakslqed vtwelvvlrr mlkewktawa liiewhhetv
      481 enllqslgdl hddvrikait tcataalerp riatsqrdsd ktiqdlpevl lpaleaalcd
      541 knahvrmaaa icqyaiqshn plarnimqta llkgnsvdsw aaaqclaleg tatypvikri
      601 lhqlftkkne dteeqsyill sylsekttli htmlavelns cqwknrivac qafsrisgnv
      661 cldmkhkliq lmwndwnkev rraaaqalgq mslgkevhdi irclnas
//
LOCUS       XP_011535063             644 aa            linear   PRI 05-AUG-2025
DEFINITION  HEAT repeat-containing protein 4 isoform X3 [Homo sapiens].
ACCESSION   XP_011535063
VERSION     XP_011535063.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536761.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..644
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..644
                     /product="HEAT repeat-containing protein 4 isoform X3"
                     /calculated_mol_wt=73775
     Region          530..559
                     /region_name="HEAT"
                     /note="HEAT repeat; pfam02985"
                     /db_xref="CDD:460773"
     CDS             1..644
                     /gene="HEATR4"
                     /coded_by="XM_011536761.4:1..1935"
                     /db_xref="GeneID:399671"
                     /db_xref="HGNC:HGNC:16761"
ORIGIN      
        1 mtrtqkgktf lphcfyqslp prlgwgmiln ysklkgkeec asvssvpmvf fssqyrlhrk
       61 sqylkmaaan ltfsqevvwq rglpsipysq ysfdhlyntn diihtpqirk arpqkpvsfk
      121 flgssspltg dtslavktes sanpekklkk skpastvrea prplihhpcm hpdmlgrpps
      181 ldvnleerea wllppekear aweatvlekl nertarwiqs krprrpgasp nkwqsflrqq
      241 ydwshirdel tsasdlellk qleaeetaef edqsvilppq ekkkpelllp vyyrlpsyfq
      301 qaetveimpg nkstedihek tslsqpqtqs yfrqvtprag kfaystdntf eqeiyfdevq
      361 iihqigakrd qivlenlnry nkqlskvfpe tpekwsaqai peasyrpvqg alrwtalptp
      421 akdmllqvge kdvpiktrrl kkqakslqed vtwelvvlrr mlkewktawa liiewhhetv
      481 enllqslgdl hddvrikait tcataalerp riatsqrdsd ktiqdlpevl lpaleaalcd
      541 knahvrmaaa icqyaiqshn plarnimqta llkgnsvdsw aaaqclaleg tatypvikri
      601 lhqlftkkne dteeqsyill sylsektvcv hyrvrhsfge qlgl
//
LOCUS       XP_047287327             603 aa            linear   PRI 05-AUG-2025
DEFINITION  HEAT repeat-containing protein 4 isoform X4 [Homo sapiens].
ACCESSION   XP_047287327
VERSION     XP_047287327.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431371.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 47% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..603
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..603
                     /product="HEAT repeat-containing protein 4 isoform X4"
                     /calculated_mol_wt=68259
     Region          107..136
                     /region_name="HEAT"
                     /note="HEAT repeat; pfam02985"
                     /db_xref="CDD:460773"
     Site            order(224..225,228,231..232,235,259..260,263,266..267,270,
                     324..325,328,331..332,358..359,362,365..366)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          243..271
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          257..402
                     /region_name="HEAT"
                     /note="HEAT repeat [General function prediction only];
                     COG1413"
                     /db_xref="CDD:441023"
     Region          306..332
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          341..367
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          373..398
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     CDS             1..603
                     /gene="HEATR4"
                     /coded_by="XM_047431371.1:1154..2965"
                     /db_xref="GeneID:399671"
                     /db_xref="HGNC:HGNC:16761"
ORIGIN      
        1 mllqvgekdv piktrrlkkq akslqedvtw elvvlrrmlk ewktawalii ewhhetvenl
       61 lqslgdlhdd vrikaittca taalerpria tsqrdsdkti qdlpevllpa leaalcdkna
      121 hvrmaaaicq yaiqshnpla rnimqtallk gnsvdswaaa qclalegtat ypvikrilhq
      181 lftkknedte eqsyillsyl sekttlihtm lavelnscqw knrivacqaf srisgnvcld
      241 mkhkliqlmw ndwnkevrra aaqalgqmsl gkevhdiirv klgqgnsqer vealyligel
      301 klmtakllps flhcfsddft avrraaclaa galqirdkmv lecllnlmqr dpywkikafa
      361 iralgqigqv speltdlllw aihyeespgv rleacrsila lklqgdrvrd tfldvlllen
      421 hdavlkemyq tmkilnlgne gnqemlqeik nriktlsqkd llthkilkle mvmgkvreea
      481 krvylkpkge qgpltlqtll qetfqdemvl prrpsevcdt eavikpvkpr apnpwlqssv
      541 pglttrskvr sslvkdlrts pekriavgpf rsdypalylg kfsertffsp imsspsgkkg
      601 ahl
//
LOCUS       XP_016876779             408 aa            linear   PRI 05-AUG-2025
DEFINITION  pleckstrin homology domain-containing family D member 1 isoform X1
            [Homo sapiens].
ACCESSION   XP_016876779
VERSION     XP_016876779.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021290.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..408
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..408
                     /product="pleckstrin homology domain-containing family D
                     member 1 isoform X1"
                     /calculated_mol_wt=47911
     Region          <1..58
                     /region_name="PH-like"
                     /note="Pleckstrin homology-like domain; cl17171"
                     /db_xref="CDD:473070"
     Region          <55..>293
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     CDS             1..408
                     /gene="PLEKHD1"
                     /gene_synonym="UPF0639"
                     /coded_by="XM_017021290.1:869..2095"
                     /db_xref="GeneID:400224"
                     /db_xref="HGNC:HGNC:20148"
ORIGIN      
        1 mpyamkishq dfhgnillaa esefeqtqwl emlqesgkvt wknaqlgeam iksleaqglq
       61 lakekqeyld klmeeteelc lqreqreele rlnqvleaek qqfeevvqel rmeqeqikre
      121 leltarclkg veqekkelrh lteslqqtle elsiekkktl emleenenhl qtlanqseqp
      181 ppsgglhsnl rqieekmqql leekllaekr mkeneersra leeerefyss qsqalqnslq
      241 eltaekqqae relkaevkvr mdlerrlrea egalrsleqg lnskvrnkek eermradvsh
      301 lkrffeecir naeleakmpv imknsvyihk aatrrikscr fhrrrsstsw ndmkpsqsfm
      361 tsqldannme elkevakrls rdqrfresiy himatqpgap salsrggk
//
LOCUS       XP_011535064             379 aa            linear   PRI 05-AUG-2025
DEFINITION  pleckstrin homology domain-containing family D member 1 isoform X2
            [Homo sapiens].
ACCESSION   XP_011535064
VERSION     XP_011535064.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536762.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..379
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..379
                     /product="pleckstrin homology domain-containing family D
                     member 1 isoform X2"
                     /calculated_mol_wt=44548
     Region          <1..29
                     /region_name="PH-like"
                     /note="Pleckstrin homology-like domain; cl17171"
                     /db_xref="CDD:473070"
     Region          <26..>264
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     CDS             1..379
                     /gene="PLEKHD1"
                     /gene_synonym="UPF0639"
                     /coded_by="XM_011536762.2:40..1179"
                     /db_xref="GeneID:400224"
                     /db_xref="HGNC:HGNC:20148"
ORIGIN      
        1 mqveileekg twknaqlgea miksleaqgl qlakekqeyl dklmeeteel clqreqreel
       61 erlnqvleae kqqfeevvqe lrmeqeqikr eleltarclk gveqekkelr hlteslqqtl
      121 eelsiekkkt lemleenenh lqtlanqseq pppsgglhsn lrqieekmqq lleekllaek
      181 rmkeneersr aleeerefys sqsqalqnsl qeltaekqqa erelkaevkv rmdlerrlre
      241 aegalrsleq glnskvrnke keermradvs hlkrffeeci rnaeleakmp vimknsvyih
      301 kaatrriksc rfhrrrssts wndmkpsqsf mtsqldannm eelkevakrl srdqrfresi
      361 yhimatqpga psalsrggk
//
LOCUS       XP_011535065             323 aa            linear   PRI 05-AUG-2025
DEFINITION  pleckstrin homology domain-containing family D member 1 isoform X3
            [Homo sapiens].
ACCESSION   XP_011535065
VERSION     XP_011535065.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536763.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..323
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..323
                     /product="pleckstrin homology domain-containing family D
                     member 1 isoform X3"
                     /calculated_mol_wt=38005
     Region          <23..>208
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     CDS             1..323
                     /gene="PLEKHD1"
                     /gene_synonym="UPF0639"
                     /coded_by="XM_011536763.2:68..1039"
                     /db_xref="GeneID:400224"
                     /db_xref="HGNC:HGNC:20148"
ORIGIN      
        1 mfelerlnqv leaekqqfee vvqelrmeqe qikrelelta rclkgveqek kelrhltesl
       61 qqtleelsie kkktlemlee nenhlqtlan qseqpppsgg lhsnlrqiee kmqqlleekl
      121 laekrmkene ersraleeer efyssqsqal qnslqeltae kqqaerelka evkvrmdler
      181 rlreaegalr sleqglnskv rnkekeermr advshlkrff eecirnaele akmpvimkns
      241 vyihkaatrr ikscrfhrrr sstswndmkp sqsfmtsqld annmeelkev akrlsrdqrf
      301 resiyhimat qpgapsalsr ggk
//
LOCUS       XP_005267695             177 aa            linear   PRI 05-AUG-2025
DEFINITION  nutritionally-regulated adipose and cardiac enriched protein
            homolog isoform X1 [Homo sapiens].
ACCESSION   XP_005267695
VERSION     XP_005267695.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267638.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..177
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..177
                     /product="nutritionally-regulated adipose and cardiac
                     enriched protein homolog isoform X1"
                     /calculated_mol_wt=18971
     Region          33..>108
                     /region_name="Consortin_C"
                     /note="Consortin C-terminus; cl20010"
                     /db_xref="CDD:473272"
     CDS             1..177
                     /gene="C14orf180"
                     /gene_synonym="C14orf77; NRAC"
                     /coded_by="XM_005267638.4:383..916"
                     /db_xref="GeneID:400258"
                     /db_xref="HGNC:HGNC:33795"
                     /db_xref="MIM:619392"
ORIGIN      
        1 mrtaagavsp dsrpetrrqt rkneeaawgp rvcraeredn rkcppsilkr srpehhrpea
       61 kpqrtsrrvw freppavtvh yiadknatat vravcvrpar agpgpilrpg qargngtggp
      121 agpaprpcpa paargphlla rppaaltgrt grtgrasrra qalrglrdsl spgpaaw
//
LOCUS       XP_011535066             177 aa            linear   PRI 05-AUG-2025
DEFINITION  nutritionally-regulated adipose and cardiac enriched protein
            homolog isoform X1 [Homo sapiens].
ACCESSION   XP_011535066
VERSION     XP_011535066.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536764.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..177
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..177
                     /product="nutritionally-regulated adipose and cardiac
                     enriched protein homolog isoform X1"
                     /calculated_mol_wt=18971
     Region          33..>108
                     /region_name="Consortin_C"
                     /note="Consortin C-terminus; cl20010"
                     /db_xref="CDD:473272"
     CDS             1..177
                     /gene="C14orf180"
                     /gene_synonym="C14orf77; NRAC"
                     /coded_by="XM_011536764.3:360..893"
                     /db_xref="GeneID:400258"
                     /db_xref="HGNC:HGNC:33795"
                     /db_xref="MIM:619392"
ORIGIN      
        1 mrtaagavsp dsrpetrrqt rkneeaawgp rvcraeredn rkcppsilkr srpehhrpea
       61 kpqrtsrrvw freppavtvh yiadknatat vravcvrpar agpgpilrpg qargngtggp
      121 agpaprpcpa paargphlla rppaaltgrt grtgrasrra qalrglrdsl spgpaaw
//
LOCUS       XP_047287333             739 aa            linear   PRI 05-AUG-2025
DEFINITION  MAP/microtubule affinity-regulating kinase 3 isoform X1 [Homo
            sapiens].
ACCESSION   XP_047287333
VERSION     XP_047287333.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431377.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..739
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..739
                     /product="MAP/microtubule affinity-regulating kinase 3
                     isoform X1"
                     /calculated_mol_wt=82801
     Region          41..293
                     /region_name="STKc_MARK"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     MAP/microtubule affinity-regulating kinases; cd14072"
                     /db_xref="CDD:270974"
     Site            order(48..52,56,69,71,102,118..121,125,127..128,130,
                     163..164,166,168..169,171,181..182,185,198..203,205,
                     235..238,240)
                     /site_type="active"
                     /db_xref="CDD:270974"
     Site            order(48..51,56,69,71,102,118..121,125,168..169,171,
                     181..182)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270974"
     Site            order(52,125,127,163..164,166,168,185,199..203,205)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270974"
     Site            181..203
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270974"
     Region          311..353
                     /region_name="UBA_MARK3_4"
                     /note="UBA domain found in MAP/microtubule
                     affinity-regulating kinase MARK3, MARK4, and similar
                     proteins; cd14407"
                     /db_xref="CDD:270590"
     Region          640..737
                     /region_name="MARK1-3_C"
                     /note="C-terminal, kinase associated domain 1 (KA1), a
                     phospholipid binding domain, of microtubule
                     affinity-regulating kinases 1-3; cd12196"
                     /db_xref="CDD:213381"
     Site            order(642,645,715,717..718)
                     /site_type="other"
                     /note="putative phospholipid binding site [chemical
                     binding]"
                     /db_xref="CDD:213381"
     CDS             1..739
                     /gene="MARK3"
                     /gene_synonym="CTAK1; KP78; Par-1a; PAR1A; VIPB"
                     /coded_by="XM_047431377.1:100..2319"
                     /db_xref="GeneID:4140"
                     /db_xref="HGNC:HGNC:6897"
                     /db_xref="MIM:602678"
ORIGIN      
        1 mwehtshgdg rqevtsrtsr sgarcrnsia scadeqphig nyrllktigk gnfakvklar
       61 hiltgrevai kiidktqlnp tslqklfrev rimkilnhpn ivklfeviet ektlylimey
      121 asggevfdyl vahgrmkeke arskfrqivs avqychqkri vhrdlkaenl lldadmniki
      181 adfgfsneft vggkldtfcg sppyaapelf qgkkydgpev dvwslgvily tlvsgslpfd
      241 gqnlkelrer vlrgkyripf ymstdcenll krflvlnpik rgtleqimkd rwinagheed
      301 elkpfvepel disdqkridi mvgmgysqee iqeslskmky deitatylll grksseldas
      361 dsssssnlsl akvrpssdln nstgqsphhk vqrsvsssqk qrrysdhagp aipsvvaypk
      421 rsqtstadsd lkedgissrk ssgsavggkg iapaspmlgn asnpnkadip erkksstvps
      481 sntasggmtr rntyvcsert tadrhsviqn gkenstipdq rtpvasthsi ssaatpdrir
      541 fprgtasrst fhgqprerrt atyngppasp slsheatpls qtrsrgstnl fskltskltr
      601 rnmsfrfikr lpteyerngr yegssrnvsa eqkdenkeak prslrftwsm kttssmdpgd
      661 mmreirkvld anncdyeqre rfllfcvhgd ghaenlvqwe mevcklprls lngvrfkris
      721 gtsiafknia skianelkl
//
LOCUS       XP_005267698             738 aa            linear   PRI 05-AUG-2025
DEFINITION  MAP/microtubule affinity-regulating kinase 3 isoform X2 [Homo
            sapiens].
ACCESSION   XP_005267698
VERSION     XP_005267698.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267641.6
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Feb 3, 2014 this sequence version replaced XP_005267698.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..738
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..738
                     /product="MAP/microtubule affinity-regulating kinase 3
                     isoform X2"
                     /calculated_mol_wt=82489
     Region          55..307
                     /region_name="STKc_MARK"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     MAP/microtubule affinity-regulating kinases; cd14072"
                     /db_xref="CDD:270974"
     Site            order(62..66,70,83,85,116,132..135,139,141..142,144,
                     177..178,180,182..183,185,195..196,199,212..217,219,
                     249..252,254)
                     /site_type="active"
                     /db_xref="CDD:270974"
     Site            order(62..65,70,83,85,116,132..135,139,182..183,185,
                     195..196)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270974"
     Site            order(66,139,141,177..178,180,182,199,213..217,219)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270974"
     Site            195..217
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270974"
     Region          325..367
                     /region_name="UBA_MARK3_4"
                     /note="UBA domain found in MAP/microtubule
                     affinity-regulating kinase MARK3, MARK4, and similar
                     proteins; cd14407"
                     /db_xref="CDD:270590"
     Region          639..736
                     /region_name="MARK1-3_C"
                     /note="C-terminal, kinase associated domain 1 (KA1), a
                     phospholipid binding domain, of microtubule
                     affinity-regulating kinases 1-3; cd12196"
                     /db_xref="CDD:213381"
     Site            order(641,644,714,716..717)
                     /site_type="other"
                     /note="putative phospholipid binding site [chemical
                     binding]"
                     /db_xref="CDD:213381"
     CDS             1..738
                     /gene="MARK3"
                     /gene_synonym="CTAK1; KP78; Par-1a; PAR1A; VIPB"
                     /coded_by="XM_005267641.6:616..2832"
                     /db_xref="GeneID:4140"
                     /db_xref="HGNC:HGNC:6897"
                     /db_xref="MIM:602678"
ORIGIN      
        1 mstrtplptv nerdtenhts hgdgrqevts rtsrsgarcr nsiascadeq phignyrllk
       61 tigkgnfakv klarhiltgr evaikiidkt qlnptslqkl frevrimkil nhpnivklfe
      121 vietektlyl imeyasggev fdylvahgrm kekearskfr qivsavqych qkrivhrdlk
      181 aenllldadm nikiadfgfs neftvggkld tfcgsppyaa pelfqgkkyd gpevdvwslg
      241 vilytlvsgs lpfdgqnlke lrervlrgky ripfymstdc enllkrflvl npikrgtleq
      301 imkdrwinag heedelkpfv epeldisdqk ridimvgmgy sqeeiqesls kmkydeitat
      361 ylllgrksse ldasdsssss nlslakvrps sdlnnstgqs phhkvqrsvs ssqkqrrysd
      421 hagpaipsvv aypkrsqtst adsdlkedgi ssrkssgsav ggkgiapasp mlgnasnpnk
      481 adiperkkss tvpssntasg gmtrrntyvc serttadrhs viqngkenst ipdqrtpvas
      541 thsissaatp drirfprgta srstfhgqpr errtatyngp paspslshea tplsqtrsrg
      601 stnlfsklts kltrrnmsfr fiksrnvsae qkdenkeakp rslrftwsmk ttssmdpgdm
      661 mreirkvlda nncdyeqrer fllfcvhgdg haenlvqwem evcklprlsl ngvrfkrisg
      721 tsiafknias kianelkl
//
LOCUS       XP_005267699             737 aa            linear   PRI 05-AUG-2025
DEFINITION  MAP/microtubule affinity-regulating kinase 3 isoform X3 [Homo
            sapiens].
ACCESSION   XP_005267699
VERSION     XP_005267699.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267642.6
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Feb 3, 2014 this sequence version replaced XP_005267699.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..737
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..737
                     /product="MAP/microtubule affinity-regulating kinase 3
                     isoform X3"
                     /calculated_mol_wt=82734
     Region          55..307
                     /region_name="STKc_MARK"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     MAP/microtubule affinity-regulating kinases; cd14072"
                     /db_xref="CDD:270974"
     Site            order(62..66,70,83,85,116,132..135,139,141..142,144,
                     177..178,180,182..183,185,195..196,199,212..217,219,
                     249..252,254)
                     /site_type="active"
                     /db_xref="CDD:270974"
     Site            order(62..65,70,83,85,116,132..135,139,182..183,185,
                     195..196)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270974"
     Site            order(66,139,141,177..178,180,182,199,213..217,219)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270974"
     Site            195..217
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270974"
     Region          325..367
                     /region_name="UBA_MARK3_4"
                     /note="UBA domain found in MAP/microtubule
                     affinity-regulating kinase MARK3, MARK4, and similar
                     proteins; cd14407"
                     /db_xref="CDD:270590"
     Region          638..735
                     /region_name="MARK1-3_C"
                     /note="C-terminal, kinase associated domain 1 (KA1), a
                     phospholipid binding domain, of microtubule
                     affinity-regulating kinases 1-3; cd12196"
                     /db_xref="CDD:213381"
     Site            order(640,643,713,715..716)
                     /site_type="other"
                     /note="putative phospholipid binding site [chemical
                     binding]"
                     /db_xref="CDD:213381"
     CDS             1..737
                     /gene="MARK3"
                     /gene_synonym="CTAK1; KP78; Par-1a; PAR1A; VIPB"
                     /coded_by="XM_005267642.6:616..2829"
                     /db_xref="GeneID:4140"
                     /db_xref="HGNC:HGNC:6897"
                     /db_xref="MIM:602678"
ORIGIN      
        1 mstrtplptv nerdtenhts hgdgrqevts rtsrsgarcr nsiascadeq phignyrllk
       61 tigkgnfakv klarhiltgr evaikiidkt qlnptslqkl frevrimkil nhpnivklfe
      121 vietektlyl imeyasggev fdylvahgrm kekearskfr qivsavqych qkrivhrdlk
      181 aenllldadm nikiadfgfs neftvggkld tfcgsppyaa pelfqgkkyd gpevdvwslg
      241 vilytlvsgs lpfdgqnlke lrervlrgky ripfymstdc enllkrflvl npikrgtleq
      301 imkdrwinag heedelkpfv epeldisdqk ridimvgmgy sqeeiqesls kmkydeitat
      361 ylllgrksse vrpssdlnns tgqsphhkvq rsvsssqkqr rysdhagpai psvvaypkrs
      421 qtstadsdlk edgissrkss gsavggkgia paspmlgnas npnkadiper kksstvpssn
      481 tasggmtrrn tyvcsertta drhsviqngk enstipdqrt pvasthsiss aatpdrirfp
      541 rgtasrstfh gqprerrtat yngppaspsl sheatplsqt rsrgstnlfs kltskltrrn
      601 msfrfikrlp teyerngrye gssrnvsaeq kdenkeakpr slrftwsmkt tssmdpgdmm
      661 reirkvldan ncdyeqrerf llfcvhgdgh aenlvqweme vcklprlsln gvrfkrisgt
      721 siafkniask ianelkl
//
LOCUS       XP_047287335             730 aa            linear   PRI 05-AUG-2025
DEFINITION  MAP/microtubule affinity-regulating kinase 3 isoform X5 [Homo
            sapiens].
ACCESSION   XP_047287335
VERSION     XP_047287335.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431379.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..730
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..730
                     /product="MAP/microtubule affinity-regulating kinase 3
                     isoform X5"
                     /calculated_mol_wt=81621
     Region          41..293
                     /region_name="STKc_MARK"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     MAP/microtubule affinity-regulating kinases; cd14072"
                     /db_xref="CDD:270974"
     Site            order(48..52,56,69,71,102,118..121,125,127..128,130,
                     163..164,166,168..169,171,181..182,185,198..203,205,
                     235..238,240)
                     /site_type="active"
                     /db_xref="CDD:270974"
     Site            order(48..51,56,69,71,102,118..121,125,168..169,171,
                     181..182)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270974"
     Site            order(52,125,127,163..164,166,168,185,199..203,205)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270974"
     Site            181..203
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270974"
     Region          311..353
                     /region_name="UBA_MARK3_4"
                     /note="UBA domain found in MAP/microtubule
                     affinity-regulating kinase MARK3, MARK4, and similar
                     proteins; cd14407"
                     /db_xref="CDD:270590"
     Region          631..728
                     /region_name="MARK1-3_C"
                     /note="C-terminal, kinase associated domain 1 (KA1), a
                     phospholipid binding domain, of microtubule
                     affinity-regulating kinases 1-3; cd12196"
                     /db_xref="CDD:213381"
     Site            order(633,636,706,708..709)
                     /site_type="other"
                     /note="putative phospholipid binding site [chemical
                     binding]"
                     /db_xref="CDD:213381"
     CDS             1..730
                     /gene="MARK3"
                     /gene_synonym="CTAK1; KP78; Par-1a; PAR1A; VIPB"
                     /coded_by="XM_047431379.1:100..2292"
                     /db_xref="GeneID:4140"
                     /db_xref="HGNC:HGNC:6897"
                     /db_xref="MIM:602678"
ORIGIN      
        1 mwehtshgdg rqevtsrtsr sgarcrnsia scadeqphig nyrllktigk gnfakvklar
       61 hiltgrevai kiidktqlnp tslqklfrev rimkilnhpn ivklfeviet ektlylimey
      121 asggevfdyl vahgrmkeke arskfrqivs avqychqkri vhrdlkaenl lldadmniki
      181 adfgfsneft vggkldtfcg sppyaapelf qgkkydgpev dvwslgvily tlvsgslpfd
      241 gqnlkelrer vlrgkyripf ymstdcenll krflvlnpik rgtleqimkd rwinagheed
      301 elkpfvepel disdqkridi mvgmgysqee iqeslskmky deitatylll grksseldas
      361 dsssssnlsl akvrpssdln nstgqsphhk vqrsvsssqk qrrysdhagp aipsvvaypk
      421 rsqtstadsd lkedgissrk ssgsavggkg iapaspmlgn asnpnkadip erkksstvps
      481 sntasggmtr rntyvcsert tadrhsviqn gkenstipdq rtpvasthsi ssaatpdrir
      541 fprgtasrst fhgqprerrt atyngppasp slsheatpls qtrsrgstnl fskltskltr
      601 rlpteyerng ryegssrnvs aeqkdenkea kprslrftws mkttssmdpg dmmreirkvl
      661 danncdyeqr erfllfcvhg dghaenlvqw emevcklprl slngvrfkri sgtsiafkni
      721 askianelkl
//
LOCUS       XP_047287337             723 aa            linear   PRI 05-AUG-2025
DEFINITION  MAP/microtubule affinity-regulating kinase 3 isoform X7 [Homo
            sapiens].
ACCESSION   XP_047287337
VERSION     XP_047287337.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431381.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..723
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..723
                     /product="MAP/microtubule affinity-regulating kinase 3
                     isoform X7"
                     /calculated_mol_wt=81237
     Region          41..293
                     /region_name="STKc_MARK"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     MAP/microtubule affinity-regulating kinases; cd14072"
                     /db_xref="CDD:270974"
     Site            order(48..52,56,69,71,102,118..121,125,127..128,130,
                     163..164,166,168..169,171,181..182,185,198..203,205,
                     235..238,240)
                     /site_type="active"
                     /db_xref="CDD:270974"
     Site            order(48..51,56,69,71,102,118..121,125,168..169,171,
                     181..182)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270974"
     Site            order(52,125,127,163..164,166,168,185,199..203,205)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270974"
     Site            181..203
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270974"
     Region          311..353
                     /region_name="UBA_MARK3_4"
                     /note="UBA domain found in MAP/microtubule
                     affinity-regulating kinase MARK3, MARK4, and similar
                     proteins; cd14407"
                     /db_xref="CDD:270590"
     Region          624..721
                     /region_name="MARK1-3_C"
                     /note="C-terminal, kinase associated domain 1 (KA1), a
                     phospholipid binding domain, of microtubule
                     affinity-regulating kinases 1-3; cd12196"
                     /db_xref="CDD:213381"
     Site            order(626,629,699,701..702)
                     /site_type="other"
                     /note="putative phospholipid binding site [chemical
                     binding]"
                     /db_xref="CDD:213381"
     CDS             1..723
                     /gene="MARK3"
                     /gene_synonym="CTAK1; KP78; Par-1a; PAR1A; VIPB"
                     /coded_by="XM_047431381.1:203..2374"
                     /db_xref="GeneID:4140"
                     /db_xref="HGNC:HGNC:6897"
                     /db_xref="MIM:602678"
ORIGIN      
        1 mwehtshgdg rqevtsrtsr sgarcrnsia scadeqphig nyrllktigk gnfakvklar
       61 hiltgrevai kiidktqlnp tslqklfrev rimkilnhpn ivklfeviet ektlylimey
      121 asggevfdyl vahgrmkeke arskfrqivs avqychqkri vhrdlkaenl lldadmniki
      181 adfgfsneft vggkldtfcg sppyaapelf qgkkydgpev dvwslgvily tlvsgslpfd
      241 gqnlkelrer vlrgkyripf ymstdcenll krflvlnpik rgtleqimkd rwinagheed
      301 elkpfvepel disdqkridi mvgmgysqee iqeslskmky deitatylll grkssevrps
      361 sdlnnstgqs phhkvqrsvs ssqkqrrysd hagpaipsvv aypkrsqtst adsdlkedgi
      421 ssrkssgsav ggkgiapasp mlgnasnpnk adiperkkss tvpssntasg gmtrrntyvc
      481 serttadrhs viqngkenst ipdqrtpvas thsissaatp drirfprgta srstfhgqpr
      541 errtatyngp paspslshea tplsqtrsrg stnlfsklts kltrrnmsfr fikrlpteye
      601 rngryegssr nvsaeqkden keakprslrf twsmkttssm dpgdmmreir kvldanncdy
      661 eqrerfllfc vhgdghaenl vqwemevckl prlslngvrf krisgtsiaf kniaskiane
      721 lkl
//
LOCUS       XP_016876781             722 aa            linear   PRI 05-AUG-2025
DEFINITION  MAP/microtubule affinity-regulating kinase 3 isoform X8 [Homo
            sapiens].
ACCESSION   XP_016876781
VERSION     XP_016876781.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021292.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..722
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..722
                     /product="MAP/microtubule affinity-regulating kinase 3
                     isoform X8"
                     /calculated_mol_wt=80925
     Region          55..307
                     /region_name="STKc_MARK"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     MAP/microtubule affinity-regulating kinases; cd14072"
                     /db_xref="CDD:270974"
     Site            order(62..66,70,83,85,116,132..135,139,141..142,144,
                     177..178,180,182..183,185,195..196,199,212..217,219,
                     249..252,254)
                     /site_type="active"
                     /db_xref="CDD:270974"
     Site            order(62..65,70,83,85,116,132..135,139,182..183,185,
                     195..196)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270974"
     Site            order(66,139,141,177..178,180,182,199,213..217,219)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270974"
     Site            195..217
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270974"
     Region          325..367
                     /region_name="UBA_MARK3_4"
                     /note="UBA domain found in MAP/microtubule
                     affinity-regulating kinase MARK3, MARK4, and similar
                     proteins; cd14407"
                     /db_xref="CDD:270590"
     Region          623..720
                     /region_name="MARK1-3_C"
                     /note="C-terminal, kinase associated domain 1 (KA1), a
                     phospholipid binding domain, of microtubule
                     affinity-regulating kinases 1-3; cd12196"
                     /db_xref="CDD:213381"
     Site            order(625,628,698,700..701)
                     /site_type="other"
                     /note="putative phospholipid binding site [chemical
                     binding]"
                     /db_xref="CDD:213381"
     CDS             1..722
                     /gene="MARK3"
                     /gene_synonym="CTAK1; KP78; Par-1a; PAR1A; VIPB"
                     /coded_by="XM_017021292.3:616..2784"
                     /db_xref="GeneID:4140"
                     /db_xref="HGNC:HGNC:6897"
                     /db_xref="MIM:602678"
ORIGIN      
        1 mstrtplptv nerdtenhts hgdgrqevts rtsrsgarcr nsiascadeq phignyrllk
       61 tigkgnfakv klarhiltgr evaikiidkt qlnptslqkl frevrimkil nhpnivklfe
      121 vietektlyl imeyasggev fdylvahgrm kekearskfr qivsavqych qkrivhrdlk
      181 aenllldadm nikiadfgfs neftvggkld tfcgsppyaa pelfqgkkyd gpevdvwslg
      241 vilytlvsgs lpfdgqnlke lrervlrgky ripfymstdc enllkrflvl npikrgtleq
      301 imkdrwinag heedelkpfv epeldisdqk ridimvgmgy sqeeiqesls kmkydeitat
      361 ylllgrksse vrpssdlnns tgqsphhkvq rsvsssqkqr rysdhagpai psvvaypkrs
      421 qtstadsdlk edgissrkss gsavggkgia paspmlgnas npnkadiper kksstvpssn
      481 tasggmtrrn tyvcsertta drhsviqngk enstipdqrt pvasthsiss aatpdrirfp
      541 rgtasrstfh gqprerrtat yngppaspsl sheatplsqt rsrgstnlfs kltskltrrn
      601 msfrfiksrn vsaeqkdenk eakprslrft wsmkttssmd pgdmmreirk vldanncdye
      661 qrerfllfcv hgdghaenlv qwemevcklp rlslngvrfk risgtsiafk niaskianel
      721 kl
//
LOCUS       XP_047287338             720 aa            linear   PRI 05-AUG-2025
DEFINITION  MAP/microtubule affinity-regulating kinase 3 isoform X9 [Homo
            sapiens].
ACCESSION   XP_047287338
VERSION     XP_047287338.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431382.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..720
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..720
                     /product="MAP/microtubule affinity-regulating kinase 3
                     isoform X9"
                     /calculated_mol_wt=80496
     Region          55..289
                     /region_name="STKc_MARK"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     MAP/microtubule affinity-regulating kinases; cd14072"
                     /db_xref="CDD:270974"
     Site            order(62..66,70,98,114..117,121,123..124,126,159..160,162,
                     164..165,167,177..178,181,194..199,201,231..234,236)
                     /site_type="active"
                     /db_xref="CDD:270974"
     Site            order(62..65,70,98,114..117,121,164..165,167,177..178)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270974"
     Site            order(66,121,123,159..160,162,164,181,195..199,201)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270974"
     Site            177..199
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270974"
     Region          307..349
                     /region_name="UBA_MARK3_4"
                     /note="UBA domain found in MAP/microtubule
                     affinity-regulating kinase MARK3, MARK4, and similar
                     proteins; cd14407"
                     /db_xref="CDD:270590"
     Region          621..718
                     /region_name="MARK1-3_C"
                     /note="C-terminal, kinase associated domain 1 (KA1), a
                     phospholipid binding domain, of microtubule
                     affinity-regulating kinases 1-3; cd12196"
                     /db_xref="CDD:213381"
     Site            order(623,626,696,698..699)
                     /site_type="other"
                     /note="putative phospholipid binding site [chemical
                     binding]"
                     /db_xref="CDD:213381"
     CDS             1..720
                     /gene="MARK3"
                     /gene_synonym="CTAK1; KP78; Par-1a; PAR1A; VIPB"
                     /coded_by="XM_047431382.1:616..2778"
                     /db_xref="GeneID:4140"
                     /db_xref="HGNC:HGNC:6897"
                     /db_xref="MIM:602678"
ORIGIN      
        1 mstrtplptv nerdtenhts hgdgrqevts rtsrsgarcr nsiascadeq phignyrllk
       61 tigkgnfakv klarhiltgr elfrevrimk ilnhpnivkl fevietektl ylimeyasgg
      121 evfdylvahg rmkekearsk frqivsavqy chqkrivhrd lkaenlllda dmnikiadfg
      181 fsneftvggk ldtfcgsppy aapelfqgkk ydgpevdvws lgvilytlvs gslpfdgqnl
      241 kelrervlrg kyripfymst dcenllkrfl vlnpikrgtl eqimkdrwin agheedelkp
      301 fvepeldisd qkridimvgm gysqeeiqes lskmkydeit atylllgrks seldasdsss
      361 ssnlslakvr pssdlnnstg qsphhkvqrs vsssqkqrry sdhagpaips vvaypkrsqt
      421 stadsdlked gissrkssgs avggkgiapa spmlgnasnp nkadiperkk sstvpssnta
      481 sggmtrrnty vcserttadr hsviqngken stipdqrtpv asthsissaa tpdrirfprg
      541 tasrstfhgq prerrtatyn gppaspslsh eatplsqtrs rgstnlfskl tskltrrnms
      601 frfiksrnvs aeqkdenkea kprslrftws mkttssmdpg dmmreirkvl danncdyeqr
      661 erfllfcvhg dghaenlvqw emevcklprl slngvrfkri sgtsiafkni askianelkl
//
LOCUS       XP_047287339             715 aa            linear   PRI 05-AUG-2025
DEFINITION  MAP/microtubule affinity-regulating kinase 3 isoform X10 [Homo
            sapiens].
ACCESSION   XP_047287339
VERSION     XP_047287339.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431383.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..715
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..715
                     /product="MAP/microtubule affinity-regulating kinase 3
                     isoform X10"
                     /calculated_mol_wt=79812
     Region          41..293
                     /region_name="STKc_MARK"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     MAP/microtubule affinity-regulating kinases; cd14072"
                     /db_xref="CDD:270974"
     Site            order(48..52,56,69,71,102,118..121,125,127..128,130,
                     163..164,166,168..169,171,181..182,185,198..203,205,
                     235..238,240)
                     /site_type="active"
                     /db_xref="CDD:270974"
     Site            order(48..51,56,69,71,102,118..121,125,168..169,171,
                     181..182)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270974"
     Site            order(52,125,127,163..164,166,168,185,199..203,205)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270974"
     Site            181..203
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270974"
     Region          311..353
                     /region_name="UBA_MARK3_4"
                     /note="UBA domain found in MAP/microtubule
                     affinity-regulating kinase MARK3, MARK4, and similar
                     proteins; cd14407"
                     /db_xref="CDD:270590"
     Region          616..713
                     /region_name="MARK1-3_C"
                     /note="C-terminal, kinase associated domain 1 (KA1), a
                     phospholipid binding domain, of microtubule
                     affinity-regulating kinases 1-3; cd12196"
                     /db_xref="CDD:213381"
     Site            order(618,621,691,693..694)
                     /site_type="other"
                     /note="putative phospholipid binding site [chemical
                     binding]"
                     /db_xref="CDD:213381"
     CDS             1..715
                     /gene="MARK3"
                     /gene_synonym="CTAK1; KP78; Par-1a; PAR1A; VIPB"
                     /coded_by="XM_047431383.1:99..2246"
                     /db_xref="GeneID:4140"
                     /db_xref="HGNC:HGNC:6897"
                     /db_xref="MIM:602678"
ORIGIN      
        1 mwehtshgdg rqevtsrtsr sgarcrnsia scadeqphig nyrllktigk gnfakvklar
       61 hiltgrevai kiidktqlnp tslqklfrev rimkilnhpn ivklfeviet ektlylimey
      121 asggevfdyl vahgrmkeke arskfrqivs avqychqkri vhrdlkaenl lldadmniki
      181 adfgfsneft vggkldtfcg sppyaapelf qgkkydgpev dvwslgvily tlvsgslpfd
      241 gqnlkelrer vlrgkyripf ymstdcenll krflvlnpik rgtleqimkd rwinagheed
      301 elkpfvepel disdqkridi mvgmgysqee iqeslskmky deitatylll grksseldas
      361 dsssssnlsl akvrpssdln nstgqsphhk vqrsvsssqk qrrysdhagp aipsvvaypk
      421 rsqtstadsd lkedgissrk ssgsavggkg iapaspmlgn asnpnkadip erkksstvps
      481 sntasggmtr rntyvcsert tadrhsviqn gkenstipdq rtpvasthsi ssaatpdrir
      541 fprgtasrst fhgqprerrt atyngppasp slsheatpls qtrsrgstnl fskltskltr
      601 srnvsaeqkd enkeakprsl rftwsmktts smdpgdmmre irkvldannc dyeqrerfll
      661 fcvhgdghae nlvqwemevc klprlslngv rfkrisgtsi afkniaskia nelkl
//
LOCUS       XP_047287340             711 aa            linear   PRI 05-AUG-2025
DEFINITION  MAP/microtubule affinity-regulating kinase 3 isoform X11 [Homo
            sapiens].
ACCESSION   XP_047287340
VERSION     XP_047287340.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431384.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..711
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..711
                     /product="MAP/microtubule affinity-regulating kinase 3
                     isoform X11"
                     /calculated_mol_wt=79316
     Region          55..289
                     /region_name="STKc_MARK"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     MAP/microtubule affinity-regulating kinases; cd14072"
                     /db_xref="CDD:270974"
     Site            order(62..66,70,98,114..117,121,123..124,126,159..160,162,
                     164..165,167,177..178,181,194..199,201,231..234,236)
                     /site_type="active"
                     /db_xref="CDD:270974"
     Site            order(62..65,70,98,114..117,121,164..165,167,177..178)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270974"
     Site            order(66,121,123,159..160,162,164,181,195..199,201)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270974"
     Site            177..199
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270974"
     Region          307..349
                     /region_name="UBA_MARK3_4"
                     /note="UBA domain found in MAP/microtubule
                     affinity-regulating kinase MARK3, MARK4, and similar
                     proteins; cd14407"
                     /db_xref="CDD:270590"
     Region          612..709
                     /region_name="MARK1-3_C"
                     /note="C-terminal, kinase associated domain 1 (KA1), a
                     phospholipid binding domain, of microtubule
                     affinity-regulating kinases 1-3; cd12196"
                     /db_xref="CDD:213381"
     Site            order(614,617,687,689..690)
                     /site_type="other"
                     /note="putative phospholipid binding site [chemical
                     binding]"
                     /db_xref="CDD:213381"
     CDS             1..711
                     /gene="MARK3"
                     /gene_synonym="CTAK1; KP78; Par-1a; PAR1A; VIPB"
                     /coded_by="XM_047431384.1:616..2751"
                     /db_xref="GeneID:4140"
                     /db_xref="HGNC:HGNC:6897"
                     /db_xref="MIM:602678"
ORIGIN      
        1 mstrtplptv nerdtenhts hgdgrqevts rtsrsgarcr nsiascadeq phignyrllk
       61 tigkgnfakv klarhiltgr elfrevrimk ilnhpnivkl fevietektl ylimeyasgg
      121 evfdylvahg rmkekearsk frqivsavqy chqkrivhrd lkaenlllda dmnikiadfg
      181 fsneftvggk ldtfcgsppy aapelfqgkk ydgpevdvws lgvilytlvs gslpfdgqnl
      241 kelrervlrg kyripfymst dcenllkrfl vlnpikrgtl eqimkdrwin agheedelkp
      301 fvepeldisd qkridimvgm gysqeeiqes lskmkydeit atylllgrks seldasdsss
      361 ssnlslakvr pssdlnnstg qsphhkvqrs vsssqkqrry sdhagpaips vvaypkrsqt
      421 stadsdlked gissrkssgs avggkgiapa spmlgnasnp nkadiperkk sstvpssnta
      481 sggmtrrnty vcserttadr hsviqngken stipdqrtpv asthsissaa tpdrirfprg
      541 tasrstfhgq prerrtatyn gppaspslsh eatplsqtrs rgstnlfskl tskltrsrnv
      601 saeqkdenke akprslrftw smkttssmdp gdmmreirkv ldanncdyeq rerfllfcvh
      661 gdghaenlvq wemevcklpr lslngvrfkr isgtsiafkn iaskianelk l
//
LOCUS       XP_047287341             708 aa            linear   PRI 05-AUG-2025
DEFINITION  MAP/microtubule affinity-regulating kinase 3 isoform X12 [Homo
            sapiens].
ACCESSION   XP_047287341
VERSION     XP_047287341.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431385.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..708
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..708
                     /product="MAP/microtubule affinity-regulating kinase 3
                     isoform X12"
                     /calculated_mol_wt=79429
     Region          41..293
                     /region_name="STKc_MARK"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     MAP/microtubule affinity-regulating kinases; cd14072"
                     /db_xref="CDD:270974"
     Site            order(48..52,56,69,71,102,118..121,125,127..128,130,
                     163..164,166,168..169,171,181..182,185,198..203,205,
                     235..238,240)
                     /site_type="active"
                     /db_xref="CDD:270974"
     Site            order(48..51,56,69,71,102,118..121,125,168..169,171,
                     181..182)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270974"
     Site            order(52,125,127,163..164,166,168,185,199..203,205)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270974"
     Site            181..203
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270974"
     Region          311..353
                     /region_name="UBA_MARK3_4"
                     /note="UBA domain found in MAP/microtubule
                     affinity-regulating kinase MARK3, MARK4, and similar
                     proteins; cd14407"
                     /db_xref="CDD:270590"
     Region          609..706
                     /region_name="MARK1-3_C"
                     /note="C-terminal, kinase associated domain 1 (KA1), a
                     phospholipid binding domain, of microtubule
                     affinity-regulating kinases 1-3; cd12196"
                     /db_xref="CDD:213381"
     Site            order(611,614,684,686..687)
                     /site_type="other"
                     /note="putative phospholipid binding site [chemical
                     binding]"
                     /db_xref="CDD:213381"
     CDS             1..708
                     /gene="MARK3"
                     /gene_synonym="CTAK1; KP78; Par-1a; PAR1A; VIPB"
                     /coded_by="XM_047431385.1:203..2329"
                     /db_xref="GeneID:4140"
                     /db_xref="HGNC:HGNC:6897"
                     /db_xref="MIM:602678"
ORIGIN      
        1 mwehtshgdg rqevtsrtsr sgarcrnsia scadeqphig nyrllktigk gnfakvklar
       61 hiltgrevai kiidktqlnp tslqklfrev rimkilnhpn ivklfeviet ektlylimey
      121 asggevfdyl vahgrmkeke arskfrqivs avqychqkri vhrdlkaenl lldadmniki
      181 adfgfsneft vggkldtfcg sppyaapelf qgkkydgpev dvwslgvily tlvsgslpfd
      241 gqnlkelrer vlrgkyripf ymstdcenll krflvlnpik rgtleqimkd rwinagheed
      301 elkpfvepel disdqkridi mvgmgysqee iqeslskmky deitatylll grkssevrps
      361 sdlnnstgqs phhkvqrsvs ssqkqrrysd hagpaipsvv aypkrsqtst adsdlkedgi
      421 ssrkssgsav ggkgiapasp mlgnasnpnk adiperkkss tvpssntasg gmtrrntyvc
      481 serttadrhs viqngkenst ipdqrtpvas thsissaatp drirfprgta srstfhgqpr
      541 errtatyngp paspslshea tplsqtrsrg stnlfsklts kltrrnmsfr fiksrnvsae
      601 qkdenkeakp rslrftwsmk ttssmdpgdm mreirkvlda nncdyeqrer fllfcvhgdg
      661 haenlvqwem evcklprlsl ngvrfkrisg tsiafknias kianelkl
//
LOCUS       XP_047287342             705 aa            linear   PRI 05-AUG-2025
DEFINITION  MAP/microtubule affinity-regulating kinase 3 isoform X13 [Homo
            sapiens].
ACCESSION   XP_047287342
VERSION     XP_047287342.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431386.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..705
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..705
                     /product="MAP/microtubule affinity-regulating kinase 3
                     isoform X13"
                     /calculated_mol_wt=79245
     Region          41..275
                     /region_name="STKc_MARK"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     MAP/microtubule affinity-regulating kinases; cd14072"
                     /db_xref="CDD:270974"
     Site            order(48..52,56,84,100..103,107,109..110,112,145..146,148,
                     150..151,153,163..164,167,180..185,187,217..220,222)
                     /site_type="active"
                     /db_xref="CDD:270974"
     Site            order(48..51,56,84,100..103,107,150..151,153,163..164)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270974"
     Site            order(52,107,109,145..146,148,150,167,181..185,187)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270974"
     Site            163..185
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270974"
     Region          293..335
                     /region_name="UBA_MARK3_4"
                     /note="UBA domain found in MAP/microtubule
                     affinity-regulating kinase MARK3, MARK4, and similar
                     proteins; cd14407"
                     /db_xref="CDD:270590"
     Region          606..703
                     /region_name="MARK1-3_C"
                     /note="C-terminal, kinase associated domain 1 (KA1), a
                     phospholipid binding domain, of microtubule
                     affinity-regulating kinases 1-3; cd12196"
                     /db_xref="CDD:213381"
     Site            order(608,611,681,683..684)
                     /site_type="other"
                     /note="putative phospholipid binding site [chemical
                     binding]"
                     /db_xref="CDD:213381"
     CDS             1..705
                     /gene="MARK3"
                     /gene_synonym="CTAK1; KP78; Par-1a; PAR1A; VIPB"
                     /coded_by="XM_047431386.1:206..2323"
                     /db_xref="GeneID:4140"
                     /db_xref="HGNC:HGNC:6897"
                     /db_xref="MIM:602678"
ORIGIN      
        1 mwehtshgdg rqevtsrtsr sgarcrnsia scadeqphig nyrllktigk gnfakvklar
       61 hiltgrelfr evrimkilnh pnivklfevi etektlylim eyasggevfd ylvahgrmke
      121 kearskfrqi vsavqychqk rivhrdlkae nllldadmni kiadfgfsne ftvggkldtf
      181 cgsppyaape lfqgkkydgp evdvwslgvi lytlvsgslp fdgqnlkelr ervlrgkyri
      241 pfymstdcen llkrflvlnp ikrgtleqim kdrwinaghe edelkpfvep eldisdqkri
      301 dimvgmgysq eeiqeslskm kydeitatyl llgrkssevr pssdlnnstg qsphhkvqrs
      361 vsssqkqrry sdhagpaips vvaypkrsqt stadsdlked gissrkssgs avggkgiapa
      421 spmlgnasnp nkadiperkk sstvpssnta sggmtrrnty vcserttadr hsviqngken
      481 stipdqrtpv asthsissaa tpdrirfprg tasrstfhgq prerrtatyn gppaspslsh
      541 eatplsqtrs rgstnlfskl tskltrrnms frfikrlpte yerngryegs srnvsaeqkd
      601 enkeakprsl rftwsmktts smdpgdmmre irkvldannc dyeqrerfll fcvhgdghae
      661 nlvqwemevc klprlslngv rfkrisgtsi afkniaskia nelkl
//
LOCUS       XP_047287343             699 aa            linear   PRI 05-AUG-2025
DEFINITION  MAP/microtubule affinity-regulating kinase 3 isoform X14 [Homo
            sapiens].
ACCESSION   XP_047287343
VERSION     XP_047287343.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431387.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..699
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..699
                     /product="MAP/microtubule affinity-regulating kinase 3
                     isoform X14"
                     /calculated_mol_wt=78248
     Region          41..293
                     /region_name="STKc_MARK"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     MAP/microtubule affinity-regulating kinases; cd14072"
                     /db_xref="CDD:270974"
     Site            order(48..52,56,69,71,102,118..121,125,127..128,130,
                     163..164,166,168..169,171,181..182,185,198..203,205,
                     235..238,240)
                     /site_type="active"
                     /db_xref="CDD:270974"
     Site            order(48..51,56,69,71,102,118..121,125,168..169,171,
                     181..182)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270974"
     Site            order(52,125,127,163..164,166,168,185,199..203,205)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270974"
     Site            181..203
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270974"
     Region          311..353
                     /region_name="UBA_MARK3_4"
                     /note="UBA domain found in MAP/microtubule
                     affinity-regulating kinase MARK3, MARK4, and similar
                     proteins; cd14407"
                     /db_xref="CDD:270590"
     Region          600..697
                     /region_name="MARK1-3_C"
                     /note="C-terminal, kinase associated domain 1 (KA1), a
                     phospholipid binding domain, of microtubule
                     affinity-regulating kinases 1-3; cd12196"
                     /db_xref="CDD:213381"
     Site            order(602,605,675,677..678)
                     /site_type="other"
                     /note="putative phospholipid binding site [chemical
                     binding]"
                     /db_xref="CDD:213381"
     CDS             1..699
                     /gene="MARK3"
                     /gene_synonym="CTAK1; KP78; Par-1a; PAR1A; VIPB"
                     /coded_by="XM_047431387.1:100..2199"
                     /db_xref="GeneID:4140"
                     /db_xref="HGNC:HGNC:6897"
                     /db_xref="MIM:602678"
ORIGIN      
        1 mwehtshgdg rqevtsrtsr sgarcrnsia scadeqphig nyrllktigk gnfakvklar
       61 hiltgrevai kiidktqlnp tslqklfrev rimkilnhpn ivklfeviet ektlylimey
      121 asggevfdyl vahgrmkeke arskfrqivs avqychqkri vhrdlkaenl lldadmniki
      181 adfgfsneft vggkldtfcg sppyaapelf qgkkydgpev dvwslgvily tlvsgslpfd
      241 gqnlkelrer vlrgkyripf ymstdcenll krflvlnpik rgtleqimkd rwinagheed
      301 elkpfvepel disdqkridi mvgmgysqee iqeslskmky deitatylll grkssevrps
      361 sdlnnstgqs phhkvqrsvs ssqkqrrysd hagpaipsvv aypkrsqtst adsdlkedgi
      421 ssrkssgsav ggkgiapasp mlgnasnpnk adiperkkss tvpssntasg gmtrrntyvc
      481 serttadrhs viqngkenst ipdqrtpvas thsissaatp drirfprgta srstfhgqpr
      541 errtatyngp paspslshea tplsqtrsrg stnlfsklts kltrsrnvsa eqkdenkeak
      601 prslrftwsm kttssmdpgd mmreirkvld anncdyeqre rfllfcvhgd ghaenlvqwe
      661 mevcklprls lngvrfkris gtsiafknia skianelkl
//
LOCUS       XP_047287344             695 aa            linear   PRI 05-AUG-2025
DEFINITION  MAP/microtubule affinity-regulating kinase 3 isoform X15 [Homo
            sapiens].
ACCESSION   XP_047287344
VERSION     XP_047287344.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431388.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..695
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..695
                     /product="MAP/microtubule affinity-regulating kinase 3
                     isoform X15"
                     /calculated_mol_wt=77752
     Region          55..289
                     /region_name="STKc_MARK"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     MAP/microtubule affinity-regulating kinases; cd14072"
                     /db_xref="CDD:270974"
     Site            order(62..66,70,98,114..117,121,123..124,126,159..160,162,
                     164..165,167,177..178,181,194..199,201,231..234,236)
                     /site_type="active"
                     /db_xref="CDD:270974"
     Site            order(62..65,70,98,114..117,121,164..165,167,177..178)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270974"
     Site            order(66,121,123,159..160,162,164,181,195..199,201)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270974"
     Site            177..199
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270974"
     Region          307..349
                     /region_name="UBA_MARK3_4"
                     /note="UBA domain found in MAP/microtubule
                     affinity-regulating kinase MARK3, MARK4, and similar
                     proteins; cd14407"
                     /db_xref="CDD:270590"
     Region          596..693
                     /region_name="MARK1-3_C"
                     /note="C-terminal, kinase associated domain 1 (KA1), a
                     phospholipid binding domain, of microtubule
                     affinity-regulating kinases 1-3; cd12196"
                     /db_xref="CDD:213381"
     Site            order(598,601,671,673..674)
                     /site_type="other"
                     /note="putative phospholipid binding site [chemical
                     binding]"
                     /db_xref="CDD:213381"
     CDS             1..695
                     /gene="MARK3"
                     /gene_synonym="CTAK1; KP78; Par-1a; PAR1A; VIPB"
                     /coded_by="XM_047431388.1:616..2703"
                     /db_xref="GeneID:4140"
                     /db_xref="HGNC:HGNC:6897"
                     /db_xref="MIM:602678"
ORIGIN      
        1 mstrtplptv nerdtenhts hgdgrqevts rtsrsgarcr nsiascadeq phignyrllk
       61 tigkgnfakv klarhiltgr elfrevrimk ilnhpnivkl fevietektl ylimeyasgg
      121 evfdylvahg rmkekearsk frqivsavqy chqkrivhrd lkaenlllda dmnikiadfg
      181 fsneftvggk ldtfcgsppy aapelfqgkk ydgpevdvws lgvilytlvs gslpfdgqnl
      241 kelrervlrg kyripfymst dcenllkrfl vlnpikrgtl eqimkdrwin agheedelkp
      301 fvepeldisd qkridimvgm gysqeeiqes lskmkydeit atylllgrks sevrpssdln
      361 nstgqsphhk vqrsvsssqk qrrysdhagp aipsvvaypk rsqtstadsd lkedgissrk
      421 ssgsavggkg iapaspmlgn asnpnkadip erkksstvps sntasggmtr rntyvcsert
      481 tadrhsviqn gkenstipdq rtpvasthsi ssaatpdrir fprgtasrst fhgqprerrt
      541 atyngppasp slsheatpls qtrsrgstnl fskltskltr srnvsaeqkd enkeakprsl
      601 rftwsmktts smdpgdmmre irkvldannc dyeqrerfll fcvhgdghae nlvqwemevc
      661 klprlslngv rfkrisgtsi afkniaskia nelkl
//
LOCUS       XP_016876784             680 aa            linear   PRI 05-AUG-2025
DEFINITION  MAP/microtubule affinity-regulating kinase 3 isoform X17 [Homo
            sapiens].
ACCESSION   XP_016876784
VERSION     XP_016876784.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021295.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..680
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..680
                     /product="MAP/microtubule affinity-regulating kinase 3
                     isoform X17"
                     /calculated_mol_wt=76090
     Region          18..243
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Region          261..303
                     /region_name="UBA_MARK3_4"
                     /note="UBA domain found in MAP/microtubule
                     affinity-regulating kinase MARK3, MARK4, and similar
                     proteins; cd14407"
                     /db_xref="CDD:270590"
     Region          581..678
                     /region_name="MARK1-3_C"
                     /note="C-terminal, kinase associated domain 1 (KA1), a
                     phospholipid binding domain, of microtubule
                     affinity-regulating kinases 1-3; cd12196"
                     /db_xref="CDD:213381"
     Site            order(583,586,656,658..659)
                     /site_type="other"
                     /note="putative phospholipid binding site [chemical
                     binding]"
                     /db_xref="CDD:213381"
     CDS             1..680
                     /gene="MARK3"
                     /gene_synonym="CTAK1; KP78; Par-1a; PAR1A; VIPB"
                     /coded_by="XM_017021295.3:616..2658"
                     /db_xref="GeneID:4140"
                     /db_xref="HGNC:HGNC:6897"
                     /db_xref="MIM:602678"
ORIGIN      
        1 mstrtplptv nerdtenvai kiidktqlnp tslqklfrev rimkilnhpn ivklfeviet
       61 ektlylimey asggevfdyl vahgrmkeke arskfrqivs avqychqkri vhrdlkaenl
      121 lldadmniki adfgfsneft vggkldtfcg sppyaapelf qgkkydgpev dvwslgvily
      181 tlvsgslpfd gqnlkelrer vlrgkyripf ymstdcenll krflvlnpik rgtleqimkd
      241 rwinagheed elkpfvepel disdqkridi mvgmgysqee iqeslskmky deitatylll
      301 grksseldas dsssssnlsl akvrpssdln nstgqsphhk vqrsvsssqk qrrysdhagp
      361 aipsvvaypk rsqtstadsd lkedgissrk ssgsavggkg iapaspmlgn asnpnkadip
      421 erkksstvps sntasggmtr rntyvcsert tadrhsviqn gkenstipdq rtpvasthsi
      481 ssaatpdrir fprgtasrst fhgqprerrt atyngppasp slsheatpls qtrsrgstnl
      541 fskltskltr rlpteyerng ryegssrnvs aeqkdenkea kprslrftws mkttssmdpg
      601 dmmreirkvl danncdyeqr erfllfcvhg dghaenlvqw emevcklprl slngvrfkri
      661 sgtsiafkni askianelkl
//
LOCUS       XP_011535071             673 aa            linear   PRI 05-AUG-2025
DEFINITION  MAP/microtubule affinity-regulating kinase 3 isoform X19 [Homo
            sapiens].
ACCESSION   XP_011535071
VERSION     XP_011535071.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536769.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..673
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..673
                     /product="MAP/microtubule affinity-regulating kinase 3
                     isoform X19"
                     /calculated_mol_wt=75459
     Region          2..227
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Region          245..287
                     /region_name="UBA_MARK3_4"
                     /note="UBA domain found in MAP/microtubule
                     affinity-regulating kinase MARK3, MARK4, and similar
                     proteins; cd14407"
                     /db_xref="CDD:270590"
     Region          574..671
                     /region_name="MARK1-3_C"
                     /note="C-terminal, kinase associated domain 1 (KA1), a
                     phospholipid binding domain, of microtubule
                     affinity-regulating kinases 1-3; cd12196"
                     /db_xref="CDD:213381"
     Site            order(576,579,649,651..652)
                     /site_type="other"
                     /note="putative phospholipid binding site [chemical
                     binding]"
                     /db_xref="CDD:213381"
     CDS             1..673
                     /gene="MARK3"
                     /gene_synonym="CTAK1; KP78; Par-1a; PAR1A; VIPB"
                     /coded_by="XM_011536769.4:19..2040"
                     /db_xref="GeneID:4140"
                     /db_xref="HGNC:HGNC:6897"
                     /db_xref="MIM:602678"
ORIGIN      
        1 mvaikiidkt qlnptslqkl frevrimkil nhpnivklfe vietektlyl imeyasggev
       61 fdylvahgrm kekearskfr qivsavqych qkrivhrdlk aenllldadm nikiadfgfs
      121 neftvggkld tfcgsppyaa pelfqgkkyd gpevdvwslg vilytlvsgs lpfdgqnlke
      181 lrervlrgky ripfymstdc enllkrflvl npikrgtleq imkdrwinag heedelkpfv
      241 epeldisdqk ridimvgmgy sqeeiqesls kmkydeitat ylllgrksse ldasdsssss
      301 nlslakvrps sdlnnstgqs phhkvqrsvs ssqkqrrysd hagpaipsvv aypkrsqtst
      361 adsdlkedgi ssrkssgsav ggkgiapasp mlgnasnpnk adiperkkss tvpssntasg
      421 gmtrrntyvc serttadrhs viqngkenst ipdqrtpvas thsissaatp drirfprgta
      481 srstfhgqpr errtatyngp paspslshea tplsqtrsrg stnlfsklts kltrrnmsfr
      541 fikrlpteye rngryegssr nvsaeqkden keakprslrf twsmkttssm dpgdmmreir
      601 kvldanncdy eqrerfllfc vhgdghaenl vqwemevckl prlslngvrf krisgtsiaf
      661 kniaskiane lkl
//
LOCUS       XP_016876787             665 aa            linear   PRI 05-AUG-2025
DEFINITION  MAP/microtubule affinity-regulating kinase 3 isoform X20 [Homo
            sapiens].
ACCESSION   XP_016876787
VERSION     XP_016876787.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021298.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..665
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..665
                     /product="MAP/microtubule affinity-regulating kinase 3
                     isoform X20"
                     /calculated_mol_wt=74281
     Region          18..243
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Region          261..303
                     /region_name="UBA_MARK3_4"
                     /note="UBA domain found in MAP/microtubule
                     affinity-regulating kinase MARK3, MARK4, and similar
                     proteins; cd14407"
                     /db_xref="CDD:270590"
     Region          566..663
                     /region_name="MARK1-3_C"
                     /note="C-terminal, kinase associated domain 1 (KA1), a
                     phospholipid binding domain, of microtubule
                     affinity-regulating kinases 1-3; cd12196"
                     /db_xref="CDD:213381"
     Site            order(568,571,641,643..644)
                     /site_type="other"
                     /note="putative phospholipid binding site [chemical
                     binding]"
                     /db_xref="CDD:213381"
     CDS             1..665
                     /gene="MARK3"
                     /gene_synonym="CTAK1; KP78; Par-1a; PAR1A; VIPB"
                     /coded_by="XM_017021298.3:616..2613"
                     /db_xref="GeneID:4140"
                     /db_xref="HGNC:HGNC:6897"
                     /db_xref="MIM:602678"
ORIGIN      
        1 mstrtplptv nerdtenvai kiidktqlnp tslqklfrev rimkilnhpn ivklfeviet
       61 ektlylimey asggevfdyl vahgrmkeke arskfrqivs avqychqkri vhrdlkaenl
      121 lldadmniki adfgfsneft vggkldtfcg sppyaapelf qgkkydgpev dvwslgvily
      181 tlvsgslpfd gqnlkelrer vlrgkyripf ymstdcenll krflvlnpik rgtleqimkd
      241 rwinagheed elkpfvepel disdqkridi mvgmgysqee iqeslskmky deitatylll
      301 grksseldas dsssssnlsl akvrpssdln nstgqsphhk vqrsvsssqk qrrysdhagp
      361 aipsvvaypk rsqtstadsd lkedgissrk ssgsavggkg iapaspmlgn asnpnkadip
      421 erkksstvps sntasggmtr rntyvcsert tadrhsviqn gkenstipdq rtpvasthsi
      481 ssaatpdrir fprgtasrst fhgqprerrt atyngppasp slsheatpls qtrsrgstnl
      541 fskltskltr srnvsaeqkd enkeakprsl rftwsmktts smdpgdmmre irkvldannc
      601 dyeqrerfll fcvhgdghae nlvqwemevc klprlslngv rfkrisgtsi afkniaskia
      661 nelkl
//
LOCUS       XP_047287345             649 aa            linear   PRI 05-AUG-2025
DEFINITION  MAP/microtubule affinity-regulating kinase 3 isoform X22 [Homo
            sapiens].
ACCESSION   XP_047287345
VERSION     XP_047287345.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431389.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..649
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..649
                     /product="MAP/microtubule affinity-regulating kinase 3
                     isoform X22"
                     /calculated_mol_wt=72469
     Region          2..227
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Region          245..287
                     /region_name="UBA_MARK3_4"
                     /note="UBA domain found in MAP/microtubule
                     affinity-regulating kinase MARK3, MARK4, and similar
                     proteins; cd14407"
                     /db_xref="CDD:270590"
     Region          550..647
                     /region_name="MARK1-3_C"
                     /note="C-terminal, kinase associated domain 1 (KA1), a
                     phospholipid binding domain, of microtubule
                     affinity-regulating kinases 1-3; cd12196"
                     /db_xref="CDD:213381"
     Site            order(552,555,625,627..628)
                     /site_type="other"
                     /note="putative phospholipid binding site [chemical
                     binding]"
                     /db_xref="CDD:213381"
     CDS             1..649
                     /gene="MARK3"
                     /gene_synonym="CTAK1; KP78; Par-1a; PAR1A; VIPB"
                     /coded_by="XM_047431389.1:35..1984"
                     /db_xref="GeneID:4140"
                     /db_xref="HGNC:HGNC:6897"
                     /db_xref="MIM:602678"
ORIGIN      
        1 mvaikiidkt qlnptslqkl frevrimkil nhpnivklfe vietektlyl imeyasggev
       61 fdylvahgrm kekearskfr qivsavqych qkrivhrdlk aenllldadm nikiadfgfs
      121 neftvggkld tfcgsppyaa pelfqgkkyd gpevdvwslg vilytlvsgs lpfdgqnlke
      181 lrervlrgky ripfymstdc enllkrflvl npikrgtleq imkdrwinag heedelkpfv
      241 epeldisdqk ridimvgmgy sqeeiqesls kmkydeitat ylllgrksse ldasdsssss
      301 nlslakvrps sdlnnstgqs phhkvqrsvs ssqkqrrysd hagpaipsvv aypkrsqtst
      361 adsdlkedgi ssrkssgsav ggkgiapasp mlgnasnpnk adiperkkss tvpssntasg
      421 gmtrrntyvc serttadrhs viqngkenst ipdqrtpvas thsissaatp drirfprgta
      481 srstfhgqpr errtatyngp paspslshea tplsqtrsrg stnlfsklts kltrsrnvsa
      541 eqkdenkeak prslrftwsm kttssmdpgd mmreirkvld anncdyeqre rfllfcvhgd
      601 ghaenlvqwe mevcklprls lngvrfkris gtsiafknia skianelkl
//
LOCUS       XP_047287346             649 aa            linear   PRI 05-AUG-2025
DEFINITION  MAP/microtubule affinity-regulating kinase 3 isoform X23 [Homo
            sapiens].
ACCESSION   XP_047287346
VERSION     XP_047287346.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431390.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..649
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..649
                     /product="MAP/microtubule affinity-regulating kinase 3
                     isoform X23"
                     /calculated_mol_wt=72718
     Region          18..243
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Region          261..303
                     /region_name="UBA_MARK3_4"
                     /note="UBA domain found in MAP/microtubule
                     affinity-regulating kinase MARK3, MARK4, and similar
                     proteins; cd14407"
                     /db_xref="CDD:270590"
     Region          550..647
                     /region_name="MARK1-3_C"
                     /note="C-terminal, kinase associated domain 1 (KA1), a
                     phospholipid binding domain, of microtubule
                     affinity-regulating kinases 1-3; cd12196"
                     /db_xref="CDD:213381"
     Site            order(552,555,625,627..628)
                     /site_type="other"
                     /note="putative phospholipid binding site [chemical
                     binding]"
                     /db_xref="CDD:213381"
     CDS             1..649
                     /gene="MARK3"
                     /gene_synonym="CTAK1; KP78; Par-1a; PAR1A; VIPB"
                     /coded_by="XM_047431390.1:616..2565"
                     /db_xref="GeneID:4140"
                     /db_xref="HGNC:HGNC:6897"
                     /db_xref="MIM:602678"
ORIGIN      
        1 mstrtplptv nerdtenvai kiidktqlnp tslqklfrev rimkilnhpn ivklfeviet
       61 ektlylimey asggevfdyl vahgrmkeke arskfrqivs avqychqkri vhrdlkaenl
      121 lldadmniki adfgfsneft vggkldtfcg sppyaapelf qgkkydgpev dvwslgvily
      181 tlvsgslpfd gqnlkelrer vlrgkyripf ymstdcenll krflvlnpik rgtleqimkd
      241 rwinagheed elkpfvepel disdqkridi mvgmgysqee iqeslskmky deitatylll
      301 grkssevrps sdlnnstgqs phhkvqrsvs ssqkqrrysd hagpaipsvv aypkrsqtst
      361 adsdlkedgi ssrkssgsav ggkgiapasp mlgnasnpnk adiperkkss tvpssntasg
      421 gmtrrntyvc serttadrhs viqngkenst ipdqrtpvas thsissaatp drirfprgta
      481 srstfhgqpr errtatyngp paspslshea tplsqtrsrg stnlfsklts kltrsrnvsa
      541 eqkdenkeak prslrftwsm kttssmdpgd mmreirkvld anncdyeqre rfllfcvhgd
      601 ghaenlvqwe mevcklprls lngvrfkris gtsiafknia skianelkl
//
LOCUS       XP_047287347             627 aa            linear   PRI 05-AUG-2025
DEFINITION  MAP/microtubule affinity-regulating kinase 3 isoform X25 [Homo
            sapiens].
ACCESSION   XP_047287347
VERSION     XP_047287347.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431391.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..627
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..627
                     /product="MAP/microtubule affinity-regulating kinase 3
                     isoform X25"
                     /calculated_mol_wt=70428
     Region          55..307
                     /region_name="STKc_MARK"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     MAP/microtubule affinity-regulating kinases; cd14072"
                     /db_xref="CDD:270974"
     Site            order(62..66,70,83,85,116,132..135,139,141..142,144,
                     177..178,180,182..183,185,195..196,199,212..217,219,
                     249..252,254)
                     /site_type="active"
                     /db_xref="CDD:270974"
     Site            order(62..65,70,83,85,116,132..135,139,182..183,185,
                     195..196)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270974"
     Site            order(66,139,141,177..178,180,182,199,213..217,219)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270974"
     Site            195..217
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270974"
     Region          325..367
                     /region_name="UBA_MARK3_4"
                     /note="UBA domain found in MAP/microtubule
                     affinity-regulating kinase MARK3, MARK4, and similar
                     proteins; cd14407"
                     /db_xref="CDD:270590"
     Region          528..625
                     /region_name="MARK1-3_C"
                     /note="C-terminal, kinase associated domain 1 (KA1), a
                     phospholipid binding domain, of microtubule
                     affinity-regulating kinases 1-3; cd12196"
                     /db_xref="CDD:213381"
     Site            order(530,533,603,605..606)
                     /site_type="other"
                     /note="putative phospholipid binding site [chemical
                     binding]"
                     /db_xref="CDD:213381"
     CDS             1..627
                     /gene="MARK3"
                     /gene_synonym="CTAK1; KP78; Par-1a; PAR1A; VIPB"
                     /coded_by="XM_047431391.1:616..2499"
                     /db_xref="GeneID:4140"
                     /db_xref="HGNC:HGNC:6897"
                     /db_xref="MIM:602678"
ORIGIN      
        1 mstrtplptv nerdtenhts hgdgrqevts rtsrsgarcr nsiascadeq phignyrllk
       61 tigkgnfakv klarhiltgr evaikiidkt qlnptslqkl frevrimkil nhpnivklfe
      121 vietektlyl imeyasggev fdylvahgrm kekearskfr qivsavqych qkrivhrdlk
      181 aenllldadm nikiadfgfs neftvggkld tfcgsppyaa pelfqgkkyd gpevdvwslg
      241 vilytlvsgs lpfdgqnlke lrervlrgky ripfymstdc enllkrflvl npikrgtleq
      301 imkdrwinag heedelkpfv epeldisdqk ridimvgmgy sqeeiqesls kmkydeitat
      361 ylllgrksse vrpssdlnns tgqsphhkvq rsvsssqkqr rysdhagpai psvvaypkrs
      421 qtstadsdlk edgissrkss gsavggkgia paspmlgnas npnkadiper kksstvpssn
      481 tasggmtrrn tyvcsertta drhsviqngk ensrnvsaeq kdenkeakpr slrftwsmkt
      541 tssmdpgdmm reirkvldan ncdyeqrerf llfcvhgdgh aenlvqweme vcklprlsln
      601 gvrfkrisgt siafkniask ianelkl
//
LOCUS       XP_047287348             625 aa            linear   PRI 05-AUG-2025
DEFINITION  MAP/microtubule affinity-regulating kinase 3 isoform X26 [Homo
            sapiens].
ACCESSION   XP_047287348
VERSION     XP_047287348.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431392.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..625
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..625
                     /product="MAP/microtubule affinity-regulating kinase 3
                     isoform X26"
                     /calculated_mol_wt=70000
     Region          55..289
                     /region_name="STKc_MARK"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     MAP/microtubule affinity-regulating kinases; cd14072"
                     /db_xref="CDD:270974"
     Site            order(62..66,70,98,114..117,121,123..124,126,159..160,162,
                     164..165,167,177..178,181,194..199,201,231..234,236)
                     /site_type="active"
                     /db_xref="CDD:270974"
     Site            order(62..65,70,98,114..117,121,164..165,167,177..178)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270974"
     Site            order(66,121,123,159..160,162,164,181,195..199,201)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270974"
     Site            177..199
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270974"
     Region          307..349
                     /region_name="UBA_MARK3_4"
                     /note="UBA domain found in MAP/microtubule
                     affinity-regulating kinase MARK3, MARK4, and similar
                     proteins; cd14407"
                     /db_xref="CDD:270590"
     Region          526..623
                     /region_name="MARK1-3_C"
                     /note="C-terminal, kinase associated domain 1 (KA1), a
                     phospholipid binding domain, of microtubule
                     affinity-regulating kinases 1-3; cd12196"
                     /db_xref="CDD:213381"
     Site            order(528,531,601,603..604)
                     /site_type="other"
                     /note="putative phospholipid binding site [chemical
                     binding]"
                     /db_xref="CDD:213381"
     CDS             1..625
                     /gene="MARK3"
                     /gene_synonym="CTAK1; KP78; Par-1a; PAR1A; VIPB"
                     /coded_by="XM_047431392.1:616..2493"
                     /db_xref="GeneID:4140"
                     /db_xref="HGNC:HGNC:6897"
                     /db_xref="MIM:602678"
ORIGIN      
        1 mstrtplptv nerdtenhts hgdgrqevts rtsrsgarcr nsiascadeq phignyrllk
       61 tigkgnfakv klarhiltgr elfrevrimk ilnhpnivkl fevietektl ylimeyasgg
      121 evfdylvahg rmkekearsk frqivsavqy chqkrivhrd lkaenlllda dmnikiadfg
      181 fsneftvggk ldtfcgsppy aapelfqgkk ydgpevdvws lgvilytlvs gslpfdgqnl
      241 kelrervlrg kyripfymst dcenllkrfl vlnpikrgtl eqimkdrwin agheedelkp
      301 fvepeldisd qkridimvgm gysqeeiqes lskmkydeit atylllgrks seldasdsss
      361 ssnlslakvr pssdlnnstg qsphhkvqrs vsssqkqrry sdhagpaips vvaypkrsqt
      421 stadsdlked gissrkssgs avggkgiapa spmlgnasnp nkadiperkk sstvpssnta
      481 sggmtrrnty vcserttadr hsviqngken srnvsaeqkd enkeakprsl rftwsmktts
      541 smdpgdmmre irkvldannc dyeqrerfll fcvhgdghae nlvqwemevc klprlslngv
      601 rfkrisgtsi afkniaskia nelkl
//
LOCUS       XP_016876790             622 aa            linear   PRI 05-AUG-2025
DEFINITION  MAP/microtubule affinity-regulating kinase 3 isoform X27 [Homo
            sapiens].
ACCESSION   XP_016876790
VERSION     XP_016876790.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021301.3
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 34% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..622
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..622
                     /product="MAP/microtubule affinity-regulating kinase 3
                     isoform X27"
                     /calculated_mol_wt=69440
     Region          <1..176
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Region          194..236
                     /region_name="UBA_MARK3_4"
                     /note="UBA domain found in MAP/microtubule
                     affinity-regulating kinase MARK3, MARK4, and similar
                     proteins; cd14407"
                     /db_xref="CDD:270590"
     Region          523..620
                     /region_name="MARK1-3_C"
                     /note="C-terminal, kinase associated domain 1 (KA1), a
                     phospholipid binding domain, of microtubule
                     affinity-regulating kinases 1-3; cd12196"
                     /db_xref="CDD:213381"
     Site            order(525,528,598,600..601)
                     /site_type="other"
                     /note="putative phospholipid binding site [chemical
                     binding]"
                     /db_xref="CDD:213381"
     CDS             1..622
                     /gene="MARK3"
                     /gene_synonym="CTAK1; KP78; Par-1a; PAR1A; VIPB"
                     /coded_by="XM_017021301.3:768..2636"
                     /db_xref="GeneID:4140"
                     /db_xref="HGNC:HGNC:6897"
                     /db_xref="MIM:602678"
ORIGIN      
        1 meyasggevf dylvahgrmk ekearskfrq ivsavqychq krivhrdlka enllldadmn
       61 ikiadfgfsn eftvggkldt fcgsppyaap elfqgkkydg pevdvwslgv ilytlvsgsl
      121 pfdgqnlkel rervlrgkyr ipfymstdce nllkrflvln pikrgtleqi mkdrwinagh
      181 eedelkpfve peldisdqkr idimvgmgys qeeiqeslsk mkydeitaty lllgrkssel
      241 dasdsssssn lslakvrpss dlnnstgqsp hhkvqrsvss sqkqrrysdh agpaipsvva
      301 ypkrsqtsta dsdlkedgis srkssgsavg gkgiapaspm lgnasnpnka diperkksst
      361 vpssntasgg mtrrntyvcs erttadrhsv iqngkensti pdqrtpvast hsissaatpd
      421 rirfprgtas rstfhgqpre rrtatyngpp aspslsheat plsqtrsrgs tnlfskltsk
      481 ltrrnmsfrf ikrlpteyer ngryegssrn vsaeqkdenk eakprslrft wsmkttssmd
      541 pgdmmreirk vldanncdye qrerfllfcv hgdghaenlv qwemevcklp rlslngvrfk
      601 risgtsiafk niaskianel kl
//
LOCUS       XP_047287349             596 aa            linear   PRI 05-AUG-2025
DEFINITION  MAP/microtubule affinity-regulating kinase 3 isoform X28 [Homo
            sapiens].
ACCESSION   XP_047287349
VERSION     XP_047287349.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431393.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..596
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..596
                     /product="MAP/microtubule affinity-regulating kinase 3
                     isoform X28"
                     /calculated_mol_wt=66424
     Region          <4..150
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Region          168..210
                     /region_name="UBA_MARK3_4"
                     /note="UBA domain found in MAP/microtubule
                     affinity-regulating kinase MARK3, MARK4, and similar
                     proteins; cd14407"
                     /db_xref="CDD:270590"
     Region          497..594
                     /region_name="MARK1-3_C"
                     /note="C-terminal, kinase associated domain 1 (KA1), a
                     phospholipid binding domain, of microtubule
                     affinity-regulating kinases 1-3; cd12196"
                     /db_xref="CDD:213381"
     Site            order(499,502,572,574..575)
                     /site_type="other"
                     /note="putative phospholipid binding site [chemical
                     binding]"
                     /db_xref="CDD:213381"
     CDS             1..596
                     /gene="MARK3"
                     /gene_synonym="CTAK1; KP78; Par-1a; PAR1A; VIPB"
                     /coded_by="XM_047431393.1:110..1900"
                     /db_xref="GeneID:4140"
                     /db_xref="HGNC:HGNC:6897"
                     /db_xref="MIM:602678"
ORIGIN      
        1 mqveivsavq ychqkrivhr dlkaenllld admnikiadf gfsneftvgg kldtfcgspp
       61 yaapelfqgk kydgpevdvw slgvilytlv sgslpfdgqn lkelrervlr gkyripfyms
      121 tdcenllkrf lvlnpikrgt leqimkdrwi nagheedelk pfvepeldis dqkridimvg
      181 mgysqeeiqe slskmkydei tatylllgrk sseldasdss sssnlslakv rpssdlnnst
      241 gqsphhkvqr svsssqkqrr ysdhagpaip svvaypkrsq tstadsdlke dgissrkssg
      301 savggkgiap aspmlgnasn pnkadiperk ksstvpssnt asggmtrrnt yvcserttad
      361 rhsviqngke nstipdqrtp vasthsissa atpdrirfpr gtasrstfhg qprerrtaty
      421 ngppaspsls heatplsqtr srgstnlfsk ltskltrrnm sfrfikrlpt eyerngryeg
      481 ssrnvsaeqk denkeakprs lrftwsmktt ssmdpgdmmr eirkvldann cdyeqrerfl
      541 lfcvhgdgha enlvqwemev cklprlslng vrfkrisgts iafkniaski anelkl
//
LOCUS       XP_047287350             596 aa            linear   PRI 05-AUG-2025
DEFINITION  MAP/microtubule affinity-regulating kinase 3 isoform X28 [Homo
            sapiens].
ACCESSION   XP_047287350
VERSION     XP_047287350.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431394.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..596
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..596
                     /product="MAP/microtubule affinity-regulating kinase 3
                     isoform X28"
                     /calculated_mol_wt=66424
     Region          <4..150
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Region          168..210
                     /region_name="UBA_MARK3_4"
                     /note="UBA domain found in MAP/microtubule
                     affinity-regulating kinase MARK3, MARK4, and similar
                     proteins; cd14407"
                     /db_xref="CDD:270590"
     Region          497..594
                     /region_name="MARK1-3_C"
                     /note="C-terminal, kinase associated domain 1 (KA1), a
                     phospholipid binding domain, of microtubule
                     affinity-regulating kinases 1-3; cd12196"
                     /db_xref="CDD:213381"
     Site            order(499,502,572,574..575)
                     /site_type="other"
                     /note="putative phospholipid binding site [chemical
                     binding]"
                     /db_xref="CDD:213381"
     CDS             1..596
                     /gene="MARK3"
                     /gene_synonym="CTAK1; KP78; Par-1a; PAR1A; VIPB"
                     /coded_by="XM_047431394.1:97..1887"
                     /db_xref="GeneID:4140"
                     /db_xref="HGNC:HGNC:6897"
                     /db_xref="MIM:602678"
ORIGIN      
        1 mqveivsavq ychqkrivhr dlkaenllld admnikiadf gfsneftvgg kldtfcgspp
       61 yaapelfqgk kydgpevdvw slgvilytlv sgslpfdgqn lkelrervlr gkyripfyms
      121 tdcenllkrf lvlnpikrgt leqimkdrwi nagheedelk pfvepeldis dqkridimvg
      181 mgysqeeiqe slskmkydei tatylllgrk sseldasdss sssnlslakv rpssdlnnst
      241 gqsphhkvqr svsssqkqrr ysdhagpaip svvaypkrsq tstadsdlke dgissrkssg
      301 savggkgiap aspmlgnasn pnkadiperk ksstvpssnt asggmtrrnt yvcserttad
      361 rhsviqngke nstipdqrtp vasthsissa atpdrirfpr gtasrstfhg qprerrtaty
      421 ngppaspsls heatplsqtr srgstnlfsk ltskltrrnm sfrfikrlpt eyerngryeg
      481 ssrnvsaeqk denkeakprs lrftwsmktt ssmdpgdmmr eirkvldann cdyeqrerfl
      541 lfcvhgdgha enlvqwemev cklprlslng vrfkrisgts iafkniaski anelkl
//
LOCUS       XP_047287351             596 aa            linear   PRI 05-AUG-2025
DEFINITION  MAP/microtubule affinity-regulating kinase 3 isoform X29 [Homo
            sapiens].
ACCESSION   XP_047287351
VERSION     XP_047287351.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431395.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..596
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..596
                     /product="MAP/microtubule affinity-regulating kinase 3
                     isoform X29"
                     /calculated_mol_wt=66463
     Region          <2..150
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Region          168..210
                     /region_name="UBA_MARK3_4"
                     /note="UBA domain found in MAP/microtubule
                     affinity-regulating kinase MARK3, MARK4, and similar
                     proteins; cd14407"
                     /db_xref="CDD:270590"
     Region          497..594
                     /region_name="MARK1-3_C"
                     /note="C-terminal, kinase associated domain 1 (KA1), a
                     phospholipid binding domain, of microtubule
                     affinity-regulating kinases 1-3; cd12196"
                     /db_xref="CDD:213381"
     Site            order(499,502,572,574..575)
                     /site_type="other"
                     /note="putative phospholipid binding site [chemical
                     binding]"
                     /db_xref="CDD:213381"
     CDS             1..596
                     /gene="MARK3"
                     /gene_synonym="CTAK1; KP78; Par-1a; PAR1A; VIPB"
                     /coded_by="XM_047431395.1:16..1806"
                     /db_xref="GeneID:4140"
                     /db_xref="HGNC:HGNC:6897"
                     /db_xref="MIM:602678"
ORIGIN      
        1 mftfivsavq ychqkrivhr dlkaenllld admnikiadf gfsneftvgg kldtfcgspp
       61 yaapelfqgk kydgpevdvw slgvilytlv sgslpfdgqn lkelrervlr gkyripfyms
      121 tdcenllkrf lvlnpikrgt leqimkdrwi nagheedelk pfvepeldis dqkridimvg
      181 mgysqeeiqe slskmkydei tatylllgrk sseldasdss sssnlslakv rpssdlnnst
      241 gqsphhkvqr svsssqkqrr ysdhagpaip svvaypkrsq tstadsdlke dgissrkssg
      301 savggkgiap aspmlgnasn pnkadiperk ksstvpssnt asggmtrrnt yvcserttad
      361 rhsviqngke nstipdqrtp vasthsissa atpdrirfpr gtasrstfhg qprerrtaty
      421 ngppaspsls heatplsqtr srgstnlfsk ltskltrrnm sfrfikrlpt eyerngryeg
      481 ssrnvsaeqk denkeakprs lrftwsmktt ssmdpgdmmr eirkvldann cdyeqrerfl
      541 lfcvhgdgha enlvqwemev cklprlslng vrfkrisgts iafkniaski anelkl
//
LOCUS       XP_047287352             565 aa            linear   PRI 05-AUG-2025
DEFINITION  MAP/microtubule affinity-regulating kinase 3 isoform X30 [Homo
            sapiens].
ACCESSION   XP_047287352
VERSION     XP_047287352.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431396.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..565
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..565
                     /product="MAP/microtubule affinity-regulating kinase 3
                     isoform X30"
                     /calculated_mol_wt=63091
     Region          <2..150
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Region          168..210
                     /region_name="UBA_MARK3_4"
                     /note="UBA domain found in MAP/microtubule
                     affinity-regulating kinase MARK3, MARK4, and similar
                     proteins; cd14407"
                     /db_xref="CDD:270590"
     Region          466..563
                     /region_name="MARK1-3_C"
                     /note="C-terminal, kinase associated domain 1 (KA1), a
                     phospholipid binding domain, of microtubule
                     affinity-regulating kinases 1-3; cd12196"
                     /db_xref="CDD:213381"
     Site            order(468,471,541,543..544)
                     /site_type="other"
                     /note="putative phospholipid binding site [chemical
                     binding]"
                     /db_xref="CDD:213381"
     CDS             1..565
                     /gene="MARK3"
                     /gene_synonym="CTAK1; KP78; Par-1a; PAR1A; VIPB"
                     /coded_by="XM_047431396.1:53..1750"
                     /db_xref="GeneID:4140"
                     /db_xref="HGNC:HGNC:6897"
                     /db_xref="MIM:602678"
ORIGIN      
        1 mftfivsavq ychqkrivhr dlkaenllld admnikiadf gfsneftvgg kldtfcgspp
       61 yaapelfqgk kydgpevdvw slgvilytlv sgslpfdgqn lkelrervlr gkyripfyms
      121 tdcenllkrf lvlnpikrgt leqimkdrwi nagheedelk pfvepeldis dqkridimvg
      181 mgysqeeiqe slskmkydei tatylllgrk ssevrpssdl nnstgqsphh kvqrsvsssq
      241 kqrrysdhag paipsvvayp krsqtstads dlkedgissr kssgsavggk giapaspmlg
      301 nasnpnkadi perkksstvp ssntasggmt rrntyvcser ttadrhsviq ngkenstipd
      361 qrtpvasths issaatpdri rfprgtasrs tfhgqprerr tatyngppas pslsheatpl
      421 sqtrsrgstn lfskltsklt rrnmsfrfik srnvsaeqkd enkeakprsl rftwsmktts
      481 smdpgdmmre irkvldannc dyeqrerfll fcvhgdghae nlvqwemevc klprlslngv
      541 rfkrisgtsi afkniaskia nelkl
//
LOCUS       XP_011535075             153 aa            linear   PRI 05-AUG-2025
DEFINITION  protein max isoform X1 [Homo sapiens].
ACCESSION   XP_011535075
VERSION     XP_011535075.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536773.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..153
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..153
                     /product="protein max isoform X1"
                     /calculated_mol_wt=17516
     Region          24..92
                     /region_name="bHLHzip_Max"
                     /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain
                     found in protein Max and similar proteins; cd11406"
                     /db_xref="CDD:381412"
     Site            order(25,27..29,31..33,35..36,40,59..60)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381412"
     Site            order(39,42..43,45..46,49..51,61,64..65,68,70..72,74..75,
                     77..78,81,84..85,88..89,91..92)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:381412"
     CDS             1..153
                     /gene="MAX"
                     /gene_synonym="bHLHd4; PDMCS"
                     /coded_by="XM_011536773.4:179..640"
                     /db_xref="GeneID:4149"
                     /db_xref="HGNC:HGNC:6913"
                     /db_xref="MIM:154950"
ORIGIN      
        1 msdnddieve sdeeqprfqs aadkrahhna lerkrrdhik dsfhslrdsv pslqgekasr
       61 aqildkatey iqymrrknht hqqdiddlkr qnalleqqga lpavgitpgi rclkralrsl
      121 ewnvlckyqr lqvfrdseps plsmvvqsgq pmg
//
LOCUS       XP_024305360            1426 aa            linear   PRI 05-AUG-2025
DEFINITION  melanoma inhibitory activity protein 2 isoform X1 [Homo sapiens].
ACCESSION   XP_024305360
VERSION     XP_024305360.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449592.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1426
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1426
                     /product="melanoma inhibitory activity protein 2 isoform
                     X1"
                     /calculated_mol_wt=161284
     Region          31..103
                     /region_name="SH3_MIA2"
                     /note="Src Homology 3 domain of Melanoma Inhibitory
                     Activity 2 protein; cd11892"
                     /db_xref="CDD:212825"
     Site            order(48..50,53..57,78..79,90..92,94..95)
                     /site_type="other"
                     /note="putative polypeptide substrate binding site
                     [polypeptide binding]"
                     /db_xref="CDD:212825"
     Region          <736..1066
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          1031..>1114
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..1426
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /coded_by="XM_024449592.2:201..4481"
                     /db_xref="GeneID:4253"
                     /db_xref="HGNC:HGNC:18432"
                     /db_xref="MIM:602132"
ORIGIN      
        1 makfgvhril llaisltkcl estklladlk kcgdleceal inrvsamrdy rgpdcrylnf
       61 tkgeeisvyv klageredlw agskgkefgy fprdavqiee vfiseeiqms tkesdflcll
      121 gvsytfdned selngdygen iypyeedkde kssiyesdfq iepgfyatye stlfedqvpa
      181 leapedigst seskdweevv vesmeqdrip evhvppssav sgvkewfglg geqaeekafe
      241 sviepvqess frsrkiaved endleelnng epqtehqqes eseidsvpkt qselaseseh
      301 ipkpqstgwf gggftsylgf gdedtgleli aeesnpplqd fpnsissdke atvpcteilt
      361 ekkdtitnds lslkpswfdf gfailgfaya kedkimlddr kneedggade hehpltseld
      421 pekeqeieti kiietedqid kkpvsektde sdtipylkkf lynfdnpwnf qnipketelp
      481 fpkqildqnn vieneetgef sidnyptdnt kvmifkssys lsdmvsniel ptriheevyf
      541 epssskdsde nskpsvdteg palveidrsv entllnsqmv stdnslssqn yisqkedase
      601 fqilkylfqi dvydfmnsaf spivilterv vaalpegmrp dsnlygfpwe lvicaavvgf
      661 favlfflwrs frsvrsrlyv grekklalml sglieekskl lekfslvqke yegyevessl
      721 kdasfekeat eaqslevenq mfvegsqise atceklnrsn seledeilcl ekelkeeksk
      781 hseqdelmad iskriqsled eskslksqva eakmtfkifq mneerlkiai kdalnensql
      841 qesqkqllqe aevwkeqvse lnkqkvtfed skvhaeqvln dkeshiktlt erllkmkdwa
      901 amlgeditdd dnlelemnse sengayldnp pkgalkklih aaklnaslkt legernqiyi
      961 qlsevdktke eltehiknlq teqaslqsen thfenenqkl qqklkvmtel yqenemklhr
     1021 kltveenyrl ekeeklskvd ekishateel etyrkrakdl eeelertihs yqgqiishek
     1081 kahdnwlaar naernlndlr kenahnrqkl tetelkfell ekdpyaldvp ntafgrehsp
     1141 ygpsplgwps setraflspp tllegplrls pllpggggrg srgpgnpldh qitnergess
     1201 cdrltdphra psdtgslspp wdqdrrmmfp ppgqsypdsa lppqrqdrfc snsgrlsgpa
     1261 elrsfnmpsl dkmdgsmpse messrndtkd dlgnlnvpds slpaeneatg pgfvppplap
     1321 irgplfpvda rgpflrrgpp fpppppgamf gasrdyfppg dfpgpppapf amrnvypprg
     1381 fppylpprpg ffpppphseg rsefpsglip psnepatehp epqqet
//
LOCUS       XP_024305361            1421 aa            linear   PRI 05-AUG-2025
DEFINITION  melanoma inhibitory activity protein 2 isoform X2 [Homo sapiens].
ACCESSION   XP_024305361
VERSION     XP_024305361.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449593.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1421
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1421
                     /product="melanoma inhibitory activity protein 2 isoform
                     X2"
                     /calculated_mol_wt=160682
     Region          31..103
                     /region_name="SH3_MIA2"
                     /note="Src Homology 3 domain of Melanoma Inhibitory
                     Activity 2 protein; cd11892"
                     /db_xref="CDD:212825"
     Site            order(48..50,53..57,78..79,90..92,94..95)
                     /site_type="other"
                     /note="putative polypeptide substrate binding site
                     [polypeptide binding]"
                     /db_xref="CDD:212825"
     Region          <715..1061
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          1026..>1109
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..1421
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /coded_by="XM_024449593.2:201..4466"
                     /db_xref="GeneID:4253"
                     /db_xref="HGNC:HGNC:18432"
                     /db_xref="MIM:602132"
ORIGIN      
        1 makfgvhril llaisltkcl estklladlk kcgdleceal inrvsamrdy rgpdcrylnf
       61 tkgeeisvyv klageredlw agskgkefgy fprdavqiee vfiseeiqms tkesdflcll
      121 gvsytfdned selngdygen iypyeedkde kssiyesdfq iepgfyatye stlfedqvpa
      181 leapedigst seskdweevv vesmeqdrip evhvppssav sgvkewfglg geqaeekafe
      241 sviepvqess frsrkiaved endleelnng epqtehqqes eseidsvpkt qselaseseh
      301 ipkpqstgwf gggftsylgf gdedtgleli aeesnpplqd fpnsissdke atvpcteilt
      361 ekkdtitnds lslkpswfdf gfailgfaya kedkimlddr kneedggade hehpltseld
      421 pekeqeieti kiietedqid kkpvsektde sdtipylkkf lynfdnpwnf qnipketelp
      481 fpkqildqnn vieneetgef sidnyptdnt kvmifkssys lsdmvsniel ptriheevyf
      541 epssskdsde nskpsvdteg palveidrsv entllnsqmv stdnslssqn yisqkedase
      601 fqilkylfqi dvydfmnsaf spivilterv vaalpegmrp dsnlygfpwe lvicaavvgf
      661 favlfflwrs frsvrsrlyv grekklalml sglieekskl lekfslvqke yegyevessl
      721 kdasfekeat eaqslefveg sqiseatcek lnrsnseled eilclekelk eekskhseqd
      781 elmadiskri qsledesksl ksqvaeakmt fkifqmneer lkiaikdaln ensqlqesqk
      841 qllqeaevwk eqvselnkqk vtfedskvha eqvlndkesh iktlterllk mkdwaamlge
      901 ditdddnlel emnsesenga yldnppkgal kklihaakln aslktleger nqiyiqlsev
      961 dktkeelteh iknlqteqas lqsenthfen enqklqqklk vmtelyqene mklhrkltve
     1021 enyrlekeek lskvdekish ateeletyrk rakdleeele rtihsyqgqi ishekkahdn
     1081 wlaarnaern lndlrkenah nrqkltetel kfellekdpy aldvpntafg rehspygpsp
     1141 lgwpssetra flspptlleg plrlspllpg gggrgsrgpg npldhqitne rgesscdrlt
     1201 dphrapsdtg slsppwdqdr rmmfpppgqs ypdsalppqr qdrfcsnsgr lsgpaelrsf
     1261 nmpsldkmdg smpsemessr ndtkddlgnl nvpdsslpae neatgpgfvp pplapirgpl
     1321 fpvdargpfl rrgppfpppp pgamfgasrd yfppgdfpgp ppapfamrnv ypprgfppyl
     1381 pprpgffppp phsegrsefp sglippsnep atehpepqqe t
//
LOCUS       XP_024305362            1417 aa            linear   PRI 05-AUG-2025
DEFINITION  melanoma inhibitory activity protein 2 isoform X3 [Homo sapiens].
ACCESSION   XP_024305362
VERSION     XP_024305362.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449594.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1417
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1417
                     /product="melanoma inhibitory activity protein 2 isoform
                     X3"
                     /calculated_mol_wt=160307
     Region          31..103
                     /region_name="SH3_MIA2"
                     /note="Src Homology 3 domain of Melanoma Inhibitory
                     Activity 2 protein; cd11892"
                     /db_xref="CDD:212825"
     Site            order(48..50,53..57,78..79,90..92,94..95)
                     /site_type="other"
                     /note="putative polypeptide substrate binding site
                     [polypeptide binding]"
                     /db_xref="CDD:212825"
     Region          <715..1057
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          1022..>1105
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..1417
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /coded_by="XM_024449594.2:201..4454"
                     /db_xref="GeneID:4253"
                     /db_xref="HGNC:HGNC:18432"
                     /db_xref="MIM:602132"
ORIGIN      
        1 makfgvhril llaisltkcl estklladlk kcgdleceal inrvsamrdy rgpdcrylnf
       61 tkgeeisvyv klageredlw agskgkefgy fprdavqiee vfiseeiqms tkesdflcll
      121 gvsytfdned selngdygen iypyeedkde kssiyesdfq iepgfyatye stlfedqvpa
      181 leapedigst seskdweevv vesmeqdrip evhvppssav sgvkewfglg geqaeekafe
      241 sviepvqess frsrkiaved endleelnng epqtehqqes eseidsvpkt qselaseseh
      301 ipkpqstgwf gggftsylgf gdedtgleli aeesnpplqd fpnsissdke atvpcteilt
      361 ekkdtitnds lslkpswfdf gfailgfaya kedkimlddr kneedggade hehpltseld
      421 pekeqeieti kiietedqid kkpvsektde sdtipylkkf lynfdnpwnf qnipketelp
      481 fpkqildqnn vieneetgef sidnyptdnt kvmifkssys lsdmvsniel ptriheevyf
      541 epssskdsde nskpsvdteg palveidrsv entllnsqmv stdnslssqn yisqkedase
      601 fqilkylfqi dvydfmnsaf spivilterv vaalpegmrp dsnlygfpwe lvicaavvgf
      661 favlfflwrs frsvrsrlyv grekklalml sglieekskl lekfslvqke yegyevessl
      721 kdasfekeat eaqslevenq matceklnrs nseledeilc lekelkeeks khseqdelma
      781 diskriqsle deskslksqv aeakmtfkif qmneerlkia ikdalnensq lqesqkqllq
      841 eaevwkeqvs elnkqkvtfe dskvhaeqvl ndkeshiktl terllkmkdw aamlgeditd
      901 ddnlelemns esengayldn ppkgalkkli haaklnaslk tlegernqiy iqlsevdktk
      961 eeltehiknl qteqaslqse nthfenenqk lqqklkvmte lyqenemklh rkltveenyr
     1021 lekeeklskv dekishatee letyrkrakd leeelertih syqgqiishe kkahdnwlaa
     1081 rnaernlndl rkenahnrqk ltetelkfel lekdpyaldv pntafgrehs pygpsplgwp
     1141 ssetraflsp ptllegplrl spllpggggr gsrgpgnpld hqitnerges scdrltdphr
     1201 apsdtgslsp pwdqdrrmmf pppgqsypds alppqrqdrf csnsgrlsgp aelrsfnmps
     1261 ldkmdgsmps emessrndtk ddlgnlnvpd sslpaeneat gpgfvpppla pirgplfpvd
     1321 argpflrrgp pfpppppgam fgasrdyfpp gdfpgpppap famrnvyppr gfppylpprp
     1381 gffpppphse grsefpsgli ppsnepateh pepqqet
//
LOCUS       XP_024305363            1383 aa            linear   PRI 05-AUG-2025
DEFINITION  melanoma inhibitory activity protein 2 isoform X4 [Homo sapiens].
ACCESSION   XP_024305363
VERSION     XP_024305363.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449595.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1383
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1383
                     /product="melanoma inhibitory activity protein 2 isoform
                     X4"
                     /calculated_mol_wt=156820
     Region          31..103
                     /region_name="SH3_MIA2"
                     /note="Src Homology 3 domain of Melanoma Inhibitory
                     Activity 2 protein; cd11892"
                     /db_xref="CDD:212825"
     Site            order(48..50,53..57,78..79,90..92,94..95)
                     /site_type="other"
                     /note="putative polypeptide substrate binding site
                     [polypeptide binding]"
                     /db_xref="CDD:212825"
     Region          <736..1066
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          1031..>1114
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..1383
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /coded_by="XM_024449595.2:201..4352"
                     /db_xref="GeneID:4253"
                     /db_xref="HGNC:HGNC:18432"
                     /db_xref="MIM:602132"
ORIGIN      
        1 makfgvhril llaisltkcl estklladlk kcgdleceal inrvsamrdy rgpdcrylnf
       61 tkgeeisvyv klageredlw agskgkefgy fprdavqiee vfiseeiqms tkesdflcll
      121 gvsytfdned selngdygen iypyeedkde kssiyesdfq iepgfyatye stlfedqvpa
      181 leapedigst seskdweevv vesmeqdrip evhvppssav sgvkewfglg geqaeekafe
      241 sviepvqess frsrkiaved endleelnng epqtehqqes eseidsvpkt qselaseseh
      301 ipkpqstgwf gggftsylgf gdedtgleli aeesnpplqd fpnsissdke atvpcteilt
      361 ekkdtitnds lslkpswfdf gfailgfaya kedkimlddr kneedggade hehpltseld
      421 pekeqeieti kiietedqid kkpvsektde sdtipylkkf lynfdnpwnf qnipketelp
      481 fpkqildqnn vieneetgef sidnyptdnt kvmifkssys lsdmvsniel ptriheevyf
      541 epssskdsde nskpsvdteg palveidrsv entllnsqmv stdnslssqn yisqkedase
      601 fqilkylfqi dvydfmnsaf spivilterv vaalpegmrp dsnlygfpwe lvicaavvgf
      661 favlfflwrs frsvrsrlyv grekklalml sglieekskl lekfslvqke yegyevessl
      721 kdasfekeat eaqslevenq mfvegsqise atceklnrsn seledeilcl ekelkeeksk
      781 hseqdelmad iskriqsled eskslksqva eakmtfkifq mneerlkiai kdalnensql
      841 qesqkqllqe aevwkeqvse lnkqkvtfed skvhaeqvln dkeshiktlt erllkmkdwa
      901 amlgeditdd dnlelemnse sengayldnp pkgalkklih aaklnaslkt legernqiyi
      961 qlsevdktke eltehiknlq teqaslqsen thfenenqkl qqklkvmtel yqenemklhr
     1021 kltveenyrl ekeeklskvd ekishateel etyrkrakdl eeelertihs yqgqiishek
     1081 kahdnwlaar naernlndlr kenahnrqkl tetelkfell ekdpyaldvp ntafgrgsrg
     1141 pgnpldhqit nergesscdr ltdphrapsd tgslsppwdq drrmmfpppg qsypdsalpp
     1201 qrqdrfcsns grlsgpaelr sfnmpsldkm dgsmpsemes srndtkddlg nlnvpdsslp
     1261 aeneatgpgf vppplapirg plfpvdargp flrrgppfpp pppgamfgas rdyfppgdfp
     1321 gpppapfamr nvypprgfpp ylpprpgffp ppphsegrse fpsglippsn epatehpepq
     1381 qet
//
LOCUS       XP_047287354            1374 aa            linear   PRI 05-AUG-2025
DEFINITION  melanoma inhibitory activity protein 2 isoform X5 [Homo sapiens].
ACCESSION   XP_047287354
VERSION     XP_047287354.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431398.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1374
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1374
                     /product="melanoma inhibitory activity protein 2 isoform
                     X5"
                     /calculated_mol_wt=155843
     Region          31..103
                     /region_name="SH3_MIA2"
                     /note="Src Homology 3 domain of Melanoma Inhibitory
                     Activity 2 protein; cd11892"
                     /db_xref="CDD:212825"
     Site            order(48..50,53..57,78..79,90..92,94..95)
                     /site_type="other"
                     /note="putative polypeptide substrate binding site
                     [polypeptide binding]"
                     /db_xref="CDD:212825"
     Region          <715..1057
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          1022..>1105
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..1374
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /coded_by="XM_047431398.1:201..4325"
                     /db_xref="GeneID:4253"
                     /db_xref="HGNC:HGNC:18432"
                     /db_xref="MIM:602132"
ORIGIN      
        1 makfgvhril llaisltkcl estklladlk kcgdleceal inrvsamrdy rgpdcrylnf
       61 tkgeeisvyv klageredlw agskgkefgy fprdavqiee vfiseeiqms tkesdflcll
      121 gvsytfdned selngdygen iypyeedkde kssiyesdfq iepgfyatye stlfedqvpa
      181 leapedigst seskdweevv vesmeqdrip evhvppssav sgvkewfglg geqaeekafe
      241 sviepvqess frsrkiaved endleelnng epqtehqqes eseidsvpkt qselaseseh
      301 ipkpqstgwf gggftsylgf gdedtgleli aeesnpplqd fpnsissdke atvpcteilt
      361 ekkdtitnds lslkpswfdf gfailgfaya kedkimlddr kneedggade hehpltseld
      421 pekeqeieti kiietedqid kkpvsektde sdtipylkkf lynfdnpwnf qnipketelp
      481 fpkqildqnn vieneetgef sidnyptdnt kvmifkssys lsdmvsniel ptriheevyf
      541 epssskdsde nskpsvdteg palveidrsv entllnsqmv stdnslssqn yisqkedase
      601 fqilkylfqi dvydfmnsaf spivilterv vaalpegmrp dsnlygfpwe lvicaavvgf
      661 favlfflwrs frsvrsrlyv grekklalml sglieekskl lekfslvqke yegyevessl
      721 kdasfekeat eaqslevenq matceklnrs nseledeilc lekelkeeks khseqdelma
      781 diskriqsle deskslksqv aeakmtfkif qmneerlkia ikdalnensq lqesqkqllq
      841 eaevwkeqvs elnkqkvtfe dskvhaeqvl ndkeshiktl terllkmkdw aamlgeditd
      901 ddnlelemns esengayldn ppkgalkkli haaklnaslk tlegernqiy iqlsevdktk
      961 eeltehiknl qteqaslqse nthfenenqk lqqklkvmte lyqenemklh rkltveenyr
     1021 lekeeklskv dekishatee letyrkrakd leeelertih syqgqiishe kkahdnwlaa
     1081 rnaernlndl rkenahnrqk ltetelkfel lekdpyaldv pntafgrgsr gpgnpldhqi
     1141 tnergesscd rltdphraps dtgslsppwd qdrrmmfppp gqsypdsalp pqrqdrfcsn
     1201 sgrlsgpael rsfnmpsldk mdgsmpseme ssrndtkddl gnlnvpdssl paeneatgpg
     1261 fvppplapir gplfpvdarg pflrrgppfp ppppgamfga srdyfppgdf pgpppapfam
     1321 rnvypprgfp pylpprpgff pppphsegrs efpsglipps nepatehpep qqet
//
LOCUS       XP_024305364            1369 aa            linear   PRI 05-AUG-2025
DEFINITION  melanoma inhibitory activity protein 2 isoform X6 [Homo sapiens].
ACCESSION   XP_024305364
VERSION     XP_024305364.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449596.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1369
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1369
                     /product="melanoma inhibitory activity protein 2 isoform
                     X6"
                     /calculated_mol_wt=155241
     Region          31..103
                     /region_name="SH3_MIA2"
                     /note="Src Homology 3 domain of Melanoma Inhibitory
                     Activity 2 protein; cd11892"
                     /db_xref="CDD:212825"
     Site            order(48..50,53..57,78..79,90..92,94..95)
                     /site_type="other"
                     /note="putative polypeptide substrate binding site
                     [polypeptide binding]"
                     /db_xref="CDD:212825"
     Region          <715..1052
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          1017..>1100
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..1369
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /coded_by="XM_024449596.2:201..4310"
                     /db_xref="GeneID:4253"
                     /db_xref="HGNC:HGNC:18432"
                     /db_xref="MIM:602132"
ORIGIN      
        1 makfgvhril llaisltkcl estklladlk kcgdleceal inrvsamrdy rgpdcrylnf
       61 tkgeeisvyv klageredlw agskgkefgy fprdavqiee vfiseeiqms tkesdflcll
      121 gvsytfdned selngdygen iypyeedkde kssiyesdfq iepgfyatye stlfedqvpa
      181 leapedigst seskdweevv vesmeqdrip evhvppssav sgvkewfglg geqaeekafe
      241 sviepvqess frsrkiaved endleelnng epqtehqqes eseidsvpkt qselaseseh
      301 ipkpqstgwf gggftsylgf gdedtgleli aeesnpplqd fpnsissdke atvpcteilt
      361 ekkdtitnds lslkpswfdf gfailgfaya kedkimlddr kneedggade hehpltseld
      421 pekeqeieti kiietedqid kkpvsektde sdtipylkkf lynfdnpwnf qnipketelp
      481 fpkqildqnn vieneetgef sidnyptdnt kvmifkssys lsdmvsniel ptriheevyf
      541 epssskdsde nskpsvdteg palveidrsv entllnsqmv stdnslssqn yisqkedase
      601 fqilkylfqi dvydfmnsaf spivilterv vaalpegmrp dsnlygfpwe lvicaavvgf
      661 favlfflwrs frsvrsrlyv grekklalml sglieekskl lekfslvqke yegyevessl
      721 kdasfekeat eaqsleatce klnrsnsele deilclekel keekskhseq delmadiskr
      781 iqsledesks lksqvaeakm tfkifqmnee rlkiaikdal nensqlqesq kqllqeaevw
      841 keqvselnkq kvtfedskvh aeqvlndkes hiktlterll kmkdwaamlg editdddnle
      901 lemnseseng ayldnppkga lkklihaakl naslktlege rnqiyiqlse vdktkeelte
      961 hiknlqteqa slqsenthfe nenqklqqkl kvmtelyqen emklhrkltv eenyrlekee
     1021 klskvdekis hateeletyr krakdleeel ertihsyqgq iishekkahd nwlaarnaer
     1081 nlndlrkena hnrqkltete lkfellekdp yaldvpntaf grgsrgpgnp ldhqitnerg
     1141 esscdrltdp hrapsdtgsl sppwdqdrrm mfpppgqsyp dsalppqrqd rfcsnsgrls
     1201 gpaelrsfnm psldkmdgsm psemessrnd tkddlgnlnv pdsslpaene atgpgfvppp
     1261 lapirgplfp vdargpflrr gppfpppppg amfgasrdyf ppgdfpgppp apfamrnvyp
     1321 prgfppylpp rpgffpppph segrsefpsg lippsnepat ehpepqqet
//
LOCUS       XP_047287355            1318 aa            linear   PRI 05-AUG-2025
DEFINITION  melanoma inhibitory activity protein 2 isoform X7 [Homo sapiens].
ACCESSION   XP_047287355
VERSION     XP_047287355.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431399.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 5% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1318
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1318
                     /product="melanoma inhibitory activity protein 2 isoform
                     X7"
                     /calculated_mol_wt=149023
     Region          <628..958
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          923..>1006
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..1318
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /coded_by="XM_047431399.1:391..4347"
                     /db_xref="GeneID:4253"
                     /db_xref="HGNC:HGNC:18432"
                     /db_xref="MIM:602132"
ORIGIN      
        1 mstkesdflc llgvsytfdn edselngdyg eniypyeedk dekssiyesd fqiepgfyat
       61 yestlfedqv paleapedig stseskdwee vvvesmeqdr ipevhvppss avsgvkewfg
      121 lggeqaeeka fesviepvqe ssfrsrkiav edendleeln ngepqtehqq eseseidsvp
      181 ktqselases ehipkpqstg wfgggftsyl gfgdedtgle liaeesnppl qdfpnsissd
      241 keatvpctei ltekkdtitn dslslkpswf dfgfailgfa yakedkimld drkneedgga
      301 dehehpltse ldpekeqeie tikiietedq idkkpvsekt desdtipylk kflynfdnpw
      361 nfqnipkete lpfpkqildq nnvieneetg efsidnyptd ntkvmifkss yslsdmvsni
      421 elptriheev yfepssskds denskpsvdt egpalveidr sventllnsq mvstdnslss
      481 qnyisqkeda sefqilkylf qidvydfmns afspivilte rvvaalpegm rpdsnlygfp
      541 welvicaavv gffavlfflw rsfrsvrsrl yvgrekklal mlsglieeks kllekfslvq
      601 keyegyeves slkdasfeke ateaqsleve nqmfvegsqi seatceklnr snseledeil
      661 clekelkeek skhseqdelm adiskriqsl edeskslksq vaeakmtfki fqmneerlki
      721 aikdalnens qlqesqkqll qeaevwkeqv selnkqkvtf edskvhaeqv lndkeshikt
      781 lterllkmkd waamlgedit dddnlelemn sesengayld nppkgalkkl ihaaklnasl
      841 ktlegernqi yiqlsevdkt keeltehikn lqteqaslqs enthfenenq klqqklkvmt
      901 elyqenemkl hrkltveeny rlekeeklsk vdekishate eletyrkrak dleeelerti
      961 hsyqgqiish ekkahdnwla arnaernlnd lrkenahnrq kltetelkfe llekdpyald
     1021 vpntafgreh spygpsplgw pssetrafls pptllegplr lspllpgggg rgsrgpgnpl
     1081 dhqitnerge sscdrltdph rapsdtgsls ppwdqdrrmm fpppgqsypd salppqrqdr
     1141 fcsnsgrlsg paelrsfnmp sldkmdgsmp semessrndt kddlgnlnvp dsslpaenea
     1201 tgpgfvpppl apirgplfpv dargpflrrg ppfpppppga mfgasrdyfp pgdfpgpppa
     1261 pfamrnvypp rgfppylppr pgffpppphs egrsefpsgl ippsnepate hpepqqet
//
LOCUS       XP_024305365            1201 aa            linear   PRI 05-AUG-2025
DEFINITION  melanoma inhibitory activity protein 2 isoform X8 [Homo sapiens].
ACCESSION   XP_024305365
VERSION     XP_024305365.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449597.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1201
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1201
                     /product="melanoma inhibitory activity protein 2 isoform
                     X8"
                     /calculated_mol_wt=137063
     Region          31..103
                     /region_name="SH3_MIA2"
                     /note="Src Homology 3 domain of Melanoma Inhibitory
                     Activity 2 protein; cd11892"
                     /db_xref="CDD:212825"
     Site            order(48..50,53..57,78..79,90..92,94..95)
                     /site_type="other"
                     /note="putative polypeptide substrate binding site
                     [polypeptide binding]"
                     /db_xref="CDD:212825"
     Region          <736..1066
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          1031..>1114
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..1201
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /coded_by="XM_024449597.2:201..3806"
                     /db_xref="GeneID:4253"
                     /db_xref="HGNC:HGNC:18432"
                     /db_xref="MIM:602132"
ORIGIN      
        1 makfgvhril llaisltkcl estklladlk kcgdleceal inrvsamrdy rgpdcrylnf
       61 tkgeeisvyv klageredlw agskgkefgy fprdavqiee vfiseeiqms tkesdflcll
      121 gvsytfdned selngdygen iypyeedkde kssiyesdfq iepgfyatye stlfedqvpa
      181 leapedigst seskdweevv vesmeqdrip evhvppssav sgvkewfglg geqaeekafe
      241 sviepvqess frsrkiaved endleelnng epqtehqqes eseidsvpkt qselaseseh
      301 ipkpqstgwf gggftsylgf gdedtgleli aeesnpplqd fpnsissdke atvpcteilt
      361 ekkdtitnds lslkpswfdf gfailgfaya kedkimlddr kneedggade hehpltseld
      421 pekeqeieti kiietedqid kkpvsektde sdtipylkkf lynfdnpwnf qnipketelp
      481 fpkqildqnn vieneetgef sidnyptdnt kvmifkssys lsdmvsniel ptriheevyf
      541 epssskdsde nskpsvdteg palveidrsv entllnsqmv stdnslssqn yisqkedase
      601 fqilkylfqi dvydfmnsaf spivilterv vaalpegmrp dsnlygfpwe lvicaavvgf
      661 favlfflwrs frsvrsrlyv grekklalml sglieekskl lekfslvqke yegyevessl
      721 kdasfekeat eaqslevenq mfvegsqise atceklnrsn seledeilcl ekelkeeksk
      781 hseqdelmad iskriqsled eskslksqva eakmtfkifq mneerlkiai kdalnensql
      841 qesqkqllqe aevwkeqvse lnkqkvtfed skvhaeqvln dkeshiktlt erllkmkdwa
      901 amlgeditdd dnlelemnse sengayldnp pkgalkklih aaklnaslkt legernqiyi
      961 qlsevdktke eltehiknlq teqaslqsen thfenenqkl qqklkvmtel yqenemklhr
     1021 kltveenyrl ekeeklskvd ekishateel etyrkrakdl eeelertihs yqgqiishek
     1081 kahdnwlaar naernlndlr kenahnrqkl tetelkfell ekdpyaldvp ntafgrehsp
     1141 ygpsplgwps setraflspp tllegplrls pllpggggrd elslnddlhi fcfpsllllm
     1201 s
//
LOCUS       XP_047287357            1192 aa            linear   PRI 05-AUG-2025
DEFINITION  melanoma inhibitory activity protein 2 isoform X9 [Homo sapiens].
ACCESSION   XP_047287357
VERSION     XP_047287357.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431401.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1192
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1192
                     /product="melanoma inhibitory activity protein 2 isoform
                     X9"
                     /calculated_mol_wt=136086
     Region          31..103
                     /region_name="SH3_MIA2"
                     /note="Src Homology 3 domain of Melanoma Inhibitory
                     Activity 2 protein; cd11892"
                     /db_xref="CDD:212825"
     Site            order(48..50,53..57,78..79,90..92,94..95)
                     /site_type="other"
                     /note="putative polypeptide substrate binding site
                     [polypeptide binding]"
                     /db_xref="CDD:212825"
     Region          <715..1057
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          1022..>1105
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..1192
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /coded_by="XM_047431401.1:201..3779"
                     /db_xref="GeneID:4253"
                     /db_xref="HGNC:HGNC:18432"
                     /db_xref="MIM:602132"
ORIGIN      
        1 makfgvhril llaisltkcl estklladlk kcgdleceal inrvsamrdy rgpdcrylnf
       61 tkgeeisvyv klageredlw agskgkefgy fprdavqiee vfiseeiqms tkesdflcll
      121 gvsytfdned selngdygen iypyeedkde kssiyesdfq iepgfyatye stlfedqvpa
      181 leapedigst seskdweevv vesmeqdrip evhvppssav sgvkewfglg geqaeekafe
      241 sviepvqess frsrkiaved endleelnng epqtehqqes eseidsvpkt qselaseseh
      301 ipkpqstgwf gggftsylgf gdedtgleli aeesnpplqd fpnsissdke atvpcteilt
      361 ekkdtitnds lslkpswfdf gfailgfaya kedkimlddr kneedggade hehpltseld
      421 pekeqeieti kiietedqid kkpvsektde sdtipylkkf lynfdnpwnf qnipketelp
      481 fpkqildqnn vieneetgef sidnyptdnt kvmifkssys lsdmvsniel ptriheevyf
      541 epssskdsde nskpsvdteg palveidrsv entllnsqmv stdnslssqn yisqkedase
      601 fqilkylfqi dvydfmnsaf spivilterv vaalpegmrp dsnlygfpwe lvicaavvgf
      661 favlfflwrs frsvrsrlyv grekklalml sglieekskl lekfslvqke yegyevessl
      721 kdasfekeat eaqslevenq matceklnrs nseledeilc lekelkeeks khseqdelma
      781 diskriqsle deskslksqv aeakmtfkif qmneerlkia ikdalnensq lqesqkqllq
      841 eaevwkeqvs elnkqkvtfe dskvhaeqvl ndkeshiktl terllkmkdw aamlgeditd
      901 ddnlelemns esengayldn ppkgalkkli haaklnaslk tlegernqiy iqlsevdktk
      961 eeltehiknl qteqaslqse nthfenenqk lqqklkvmte lyqenemklh rkltveenyr
     1021 lekeeklskv dekishatee letyrkrakd leeelertih syqgqiishe kkahdnwlaa
     1081 rnaernlndl rkenahnrqk ltetelkfel lekdpyaldv pntafgrehs pygpsplgwp
     1141 ssetraflsp ptllegplrl spllpggggr delslnddlh ifcfpsllll ms
//
LOCUS       XP_047287358             931 aa            linear   PRI 05-AUG-2025
DEFINITION  melanoma inhibitory activity protein 2 isoform X10 [Homo sapiens].
ACCESSION   XP_047287358
VERSION     XP_047287358.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431402.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..931
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..931
                     /product="melanoma inhibitory activity protein 2 isoform
                     X10"
                     /calculated_mol_wt=105817
     Region          31..103
                     /region_name="SH3_MIA2"
                     /note="Src Homology 3 domain of Melanoma Inhibitory
                     Activity 2 protein; cd11892"
                     /db_xref="CDD:212825"
     Site            order(48..50,53..57,78..79,90..92,94..95)
                     /site_type="other"
                     /note="putative polypeptide substrate binding site
                     [polypeptide binding]"
                     /db_xref="CDD:212825"
     Region          682..>893
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     CDS             1..931
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /coded_by="XM_047431402.1:201..2996"
                     /db_xref="GeneID:4253"
                     /db_xref="HGNC:HGNC:18432"
                     /db_xref="MIM:602132"
ORIGIN      
        1 makfgvhril llaisltkcl estklladlk kcgdleceal inrvsamrdy rgpdcrylnf
       61 tkgeeisvyv klageredlw agskgkefgy fprdavqiee vfiseeiqms tkesdflcll
      121 gvsytfdned selngdygen iypyeedkde kssiyesdfq iepgfyatye stlfedqvpa
      181 leapedigst seskdweevv vesmeqdrip evhvppssav sgvkewfglg geqaeekafe
      241 sviepvqess frsrkiaved endleelnng epqtehqqes eseidsvpkt qselaseseh
      301 ipkpqstgwf gggftsylgf gdedtgleli aeesnpplqd fpnsissdke atvpcteilt
      361 ekkdtitnds lslkpswfdf gfailgfaya kedkimlddr kneedggade hehpltseld
      421 pekeqeieti kiietedqid kkpvsektde sdtipylkkf lynfdnpwnf qnipketelp
      481 fpkqildqnn vieneetgef sidnyptdnt kvmifkssys lsdmvsniel ptriheevyf
      541 epssskdsde nskpsvdteg palveidrsv entllnsqmv stdnslssqn yisqkedase
      601 fqilkylfqi dvydfmnsaf spivilterv vaalpegmrp dsnlygfpwe lvicaavvgf
      661 favlfflwrs frsvrsrlyv grekklalml sglieekskl lekfslvqke yegyevessl
      721 kdasfekeat eaqslevenq mfvegsqise atceklnrsn seledeilcl ekelkeeksk
      781 hseqdelmad iskriqsled eskslksqva eakmtfkifq mneerlkiai kdalnensql
      841 qesqkqllqe aevwkeqvse lnkqkvtfed skvhaeqvln dkeshiktlt erllkmkdwa
      901 amlgeditdd dnlelemnse sengaylgik s
//
LOCUS       XP_016876803             818 aa            linear   PRI 05-AUG-2025
DEFINITION  melanoma inhibitory activity protein 2 isoform X11 [Homo sapiens].
ACCESSION   XP_016876803
VERSION     XP_016876803.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021314.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..818
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..818
                     /product="melanoma inhibitory activity protein 2 isoform
                     X11"
                     /calculated_mol_wt=92444
     Region          <128..458
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          423..>506
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..818
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /coded_by="XM_017021314.2:76..2532"
                     /db_xref="GeneID:4253"
                     /db_xref="HGNC:HGNC:18432"
                     /db_xref="MIM:602132"
ORIGIN      
        1 meepgvtpqp ylgllleelr rvvaalpegm rpdsnlygfp welvicaavv gffavlfflw
       61 rsfrsvrsrl yvgrekklal mlsglieeks kllekfslvq keyegyeves slkdasfeke
      121 ateaqsleve nqmfvegsqi seatceklnr snseledeil clekelkeek skhseqdelm
      181 adiskriqsl edeskslksq vaeakmtfki fqmneerlki aikdalnens qlqesqkqll
      241 qeaevwkeqv selnkqkvtf edskvhaeqv lndkeshikt lterllkmkd waamlgedit
      301 dddnlelemn sesengayld nppkgalkkl ihaaklnasl ktlegernqi yiqlsevdkt
      361 keeltehikn lqteqaslqs enthfenenq klqqklkvmt elyqenemkl hrkltveeny
      421 rlekeeklsk vdekishate eletyrkrak dleeelerti hsyqgqiish ekkahdnwla
      481 arnaernlnd lrkenahnrq kltetelkfe llekdpyald vpntafgreh spygpsplgw
      541 pssetrafls pptllegplr lspllpgggg rgsrgpgnpl dhqitnerge sscdrltdph
      601 rapsdtgsls ppwdqdrrmm fpppgqsypd salppqrqdr fcsnsgrlsg paelrsfnmp
      661 sldkmdgsmp semessrndt kddlgnlnvp dsslpaenea tgpgfvpppl apirgplfpv
      721 dargpflrrg ppfpppppga mfgasrdyfp pgdfpgpppa pfamrnvypp rgfppylppr
      781 pgffpppphs egrsefpsgl ippsnepate hpepqqet
//
LOCUS       XP_016876804             812 aa            linear   PRI 05-AUG-2025
DEFINITION  melanoma inhibitory activity protein 2 isoform X12 [Homo sapiens].
ACCESSION   XP_016876804
VERSION     XP_016876804.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021315.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..812
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..812
                     /product="melanoma inhibitory activity protein 2 isoform
                     X12"
                     /calculated_mol_wt=91324
     Region          <122..452
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          417..>500
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..812
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /coded_by="XM_017021315.3:17..2455"
                     /db_xref="GeneID:4253"
                     /db_xref="HGNC:HGNC:18432"
                     /db_xref="MIM:602132"
ORIGIN      
        1 mtaaagfsgl pgspgvvaal pegmrpdsnl ygfpwelvic aavvgffavl fflwrsfrsv
       61 rsrlyvgrek klalmlsgli eekskllekf slvqkeyegy evesslkdas fekeateaqs
      121 levenqmfve gsqiseatce klnrsnsele deilclekel keekskhseq delmadiskr
      181 iqsledesks lksqvaeakm tfkifqmnee rlkiaikdal nensqlqesq kqllqeaevw
      241 keqvselnkq kvtfedskvh aeqvlndkes hiktlterll kmkdwaamlg editdddnle
      301 lemnseseng ayldnppkga lkklihaakl naslktlege rnqiyiqlse vdktkeelte
      361 hiknlqteqa slqsenthfe nenqklqqkl kvmtelyqen emklhrkltv eenyrlekee
      421 klskvdekis hateeletyr krakdleeel ertihsyqgq iishekkahd nwlaarnaer
      481 nlndlrkena hnrqkltete lkfellekdp yaldvpntaf grehspygps plgwpssetr
      541 aflspptlle gplrlspllp ggggrgsrgp gnpldhqitn ergesscdrl tdphrapsdt
      601 gslsppwdqd rrmmfpppgq sypdsalppq rqdrfcsnsg rlsgpaelrs fnmpsldkmd
      661 gsmpsemess rndtkddlgn lnvpdsslpa eneatgpgfv ppplapirgp lfpvdargpf
      721 lrrgppfppp ppgamfgasr dyfppgdfpg pppapfamrn vypprgfppy lpprpgffpp
      781 pphsegrsef psglippsne patehpepqq et
//
LOCUS       XP_016876805             806 aa            linear   PRI 05-AUG-2025
DEFINITION  melanoma inhibitory activity protein 2 isoform X13 [Homo sapiens].
ACCESSION   XP_016876805
VERSION     XP_016876805.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021316.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..806
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..806
                     /product="melanoma inhibitory activity protein 2 isoform
                     X13"
                     /calculated_mol_wt=91095
     Region          <116..446
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          411..>494
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..806
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /coded_by="XM_017021316.2:105..2525"
                     /db_xref="GeneID:4253"
                     /db_xref="HGNC:HGNC:18432"
                     /db_xref="MIM:602132"
ORIGIN      
        1 melkspeeev vaalpegmrp dsnlygfpwe lvicaavvgf favlfflwrs frsvrsrlyv
       61 grekklalml sglieekskl lekfslvqke yegyevessl kdasfekeat eaqslevenq
      121 mfvegsqise atceklnrsn seledeilcl ekelkeeksk hseqdelmad iskriqsled
      181 eskslksqva eakmtfkifq mneerlkiai kdalnensql qesqkqllqe aevwkeqvse
      241 lnkqkvtfed skvhaeqvln dkeshiktlt erllkmkdwa amlgeditdd dnlelemnse
      301 sengayldnp pkgalkklih aaklnaslkt legernqiyi qlsevdktke eltehiknlq
      361 teqaslqsen thfenenqkl qqklkvmtel yqenemklhr kltveenyrl ekeeklskvd
      421 ekishateel etyrkrakdl eeelertihs yqgqiishek kahdnwlaar naernlndlr
      481 kenahnrqkl tetelkfell ekdpyaldvp ntafgrehsp ygpsplgwps setraflspp
      541 tllegplrls pllpggggrg srgpgnpldh qitnergess cdrltdphra psdtgslspp
      601 wdqdrrmmfp ppgqsypdsa lppqrqdrfc snsgrlsgpa elrsfnmpsl dkmdgsmpse
      661 messrndtkd dlgnlnvpds slpaeneatg pgfvppplap irgplfpvda rgpflrrgpp
      721 fpppppgamf gasrdyfppg dfpgpppapf amrnvypprg fppylpprpg ffpppphseg
      781 rsefpsglip psnepatehp epqqet
//
LOCUS       XP_011535080             801 aa            linear   PRI 05-AUG-2025
DEFINITION  melanoma inhibitory activity protein 2 isoform X14 [Homo sapiens].
ACCESSION   XP_011535080
VERSION     XP_011535080.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536778.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..801
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..801
                     /product="melanoma inhibitory activity protein 2 isoform
                     X14"
                     /calculated_mol_wt=90493
     Region          <95..441
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          406..>489
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..801
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /coded_by="XM_011536778.3:105..2510"
                     /db_xref="GeneID:4253"
                     /db_xref="HGNC:HGNC:18432"
                     /db_xref="MIM:602132"
ORIGIN      
        1 melkspeeev vaalpegmrp dsnlygfpwe lvicaavvgf favlfflwrs frsvrsrlyv
       61 grekklalml sglieekskl lekfslvqke yegyevessl kdasfekeat eaqslefveg
      121 sqiseatcek lnrsnseled eilclekelk eekskhseqd elmadiskri qsledesksl
      181 ksqvaeakmt fkifqmneer lkiaikdaln ensqlqesqk qllqeaevwk eqvselnkqk
      241 vtfedskvha eqvlndkesh iktlterllk mkdwaamlge ditdddnlel emnsesenga
      301 yldnppkgal kklihaakln aslktleger nqiyiqlsev dktkeelteh iknlqteqas
      361 lqsenthfen enqklqqklk vmtelyqene mklhrkltve enyrlekeek lskvdekish
      421 ateeletyrk rakdleeele rtihsyqgqi ishekkahdn wlaarnaern lndlrkenah
      481 nrqkltetel kfellekdpy aldvpntafg rehspygpsp lgwpssetra flspptlleg
      541 plrlspllpg gggrgsrgpg npldhqitne rgesscdrlt dphrapsdtg slsppwdqdr
      601 rmmfpppgqs ypdsalppqr qdrfcsnsgr lsgpaelrsf nmpsldkmdg smpsemessr
      661 ndtkddlgnl nvpdsslpae neatgpgfvp pplapirgpl fpvdargpfl rrgppfpppp
      721 pgamfgasrd yfppgdfpgp ppapfamrnv ypprgfppyl pprpgffppp phsegrsefp
      781 sglippsnep atehpepqqe t
//
LOCUS       XP_047287359             797 aa            linear   PRI 05-AUG-2025
DEFINITION  melanoma inhibitory activity protein 2 isoform X15 [Homo sapiens].
ACCESSION   XP_047287359
VERSION     XP_047287359.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431403.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..797
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..797
                     /product="melanoma inhibitory activity protein 2 isoform
                     X15"
                     /calculated_mol_wt=90118
     Region          <95..437
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          402..>485
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..797
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /coded_by="XM_047431403.1:105..2498"
                     /db_xref="GeneID:4253"
                     /db_xref="HGNC:HGNC:18432"
                     /db_xref="MIM:602132"
ORIGIN      
        1 melkspeeev vaalpegmrp dsnlygfpwe lvicaavvgf favlfflwrs frsvrsrlyv
       61 grekklalml sglieekskl lekfslvqke yegyevessl kdasfekeat eaqslevenq
      121 matceklnrs nseledeilc lekelkeeks khseqdelma diskriqsle deskslksqv
      181 aeakmtfkif qmneerlkia ikdalnensq lqesqkqllq eaevwkeqvs elnkqkvtfe
      241 dskvhaeqvl ndkeshiktl terllkmkdw aamlgeditd ddnlelemns esengayldn
      301 ppkgalkkli haaklnaslk tlegernqiy iqlsevdktk eeltehiknl qteqaslqse
      361 nthfenenqk lqqklkvmte lyqenemklh rkltveenyr lekeeklskv dekishatee
      421 letyrkrakd leeelertih syqgqiishe kkahdnwlaa rnaernlndl rkenahnrqk
      481 ltetelkfel lekdpyaldv pntafgrehs pygpsplgwp ssetraflsp ptllegplrl
      541 spllpggggr gsrgpgnpld hqitnerges scdrltdphr apsdtgslsp pwdqdrrmmf
      601 pppgqsypds alppqrqdrf csnsgrlsgp aelrsfnmps ldkmdgsmps emessrndtk
      661 ddlgnlnvpd sslpaeneat gpgfvpppla pirgplfpvd argpflrrgp pfpppppgam
      721 fgasrdyfpp gdfpgpppap famrnvyppr gfppylpprp gffpppphse grsefpsgli
      781 ppsnepateh pepqqet
//
LOCUS       XP_016876806             789 aa            linear   PRI 05-AUG-2025
DEFINITION  melanoma inhibitory activity protein 2 isoform X16 [Homo sapiens].
ACCESSION   XP_016876806
VERSION     XP_016876806.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021317.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..789
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..789
                     /product="melanoma inhibitory activity protein 2 isoform
                     X16"
                     /calculated_mol_wt=89285
     Region          <99..429
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          394..>477
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..789
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /coded_by="XM_017021317.3:255..2624"
                     /db_xref="GeneID:4253"
                     /db_xref="HGNC:HGNC:18432"
                     /db_xref="MIM:602132"
ORIGIN      
        1 mrpdsnlygf pwelvicaav vgffavlffl wrsfrsvrsr lyvgrekkla lmlsglieek
       61 skllekfslv qkeyegyeve sslkdasfek eateaqslev enqmfvegsq iseatcekln
      121 rsnseledei lclekelkee kskhseqdel madiskriqs ledeskslks qvaeakmtfk
      181 ifqmneerlk iaikdalnen sqlqesqkql lqeaevwkeq vselnkqkvt fedskvhaeq
      241 vlndkeshik tlterllkmk dwaamlgedi tdddnlelem nsesengayl dnppkgalkk
      301 lihaaklnas lktlegernq iyiqlsevdk tkeeltehik nlqteqaslq senthfenen
      361 qklqqklkvm telyqenemk lhrkltveen yrlekeekls kvdekishat eeletyrkra
      421 kdleeelert ihsyqgqiis hekkahdnwl aarnaernln dlrkenahnr qkltetelkf
      481 ellekdpyal dvpntafgre hspygpsplg wpssetrafl spptllegpl rlspllpggg
      541 grgsrgpgnp ldhqitnerg esscdrltdp hrapsdtgsl sppwdqdrrm mfpppgqsyp
      601 dsalppqrqd rfcsnsgrls gpaelrsfnm psldkmdgsm psemessrnd tkddlgnlnv
      661 pdsslpaene atgpgfvppp lapirgplfp vdargpflrr gppfpppppg amfgasrdyf
      721 ppgdfpgppp apfamrnvyp prgfppylpp rpgffpppph segrsefpsg lippsnepat
      781 ehpepqqet
//
LOCUS       XP_016876819             789 aa            linear   PRI 05-AUG-2025
DEFINITION  melanoma inhibitory activity protein 2 isoform X16 [Homo sapiens].
ACCESSION   XP_016876819
VERSION     XP_016876819.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021330.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..789
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..789
                     /product="melanoma inhibitory activity protein 2 isoform
                     X16"
                     /calculated_mol_wt=89285
     Region          <99..429
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          394..>477
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..789
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /coded_by="XM_017021330.2:147..2516"
                     /db_xref="GeneID:4253"
                     /db_xref="HGNC:HGNC:18432"
                     /db_xref="MIM:602132"
ORIGIN      
        1 mrpdsnlygf pwelvicaav vgffavlffl wrsfrsvrsr lyvgrekkla lmlsglieek
       61 skllekfslv qkeyegyeve sslkdasfek eateaqslev enqmfvegsq iseatcekln
      121 rsnseledei lclekelkee kskhseqdel madiskriqs ledeskslks qvaeakmtfk
      181 ifqmneerlk iaikdalnen sqlqesqkql lqeaevwkeq vselnkqkvt fedskvhaeq
      241 vlndkeshik tlterllkmk dwaamlgedi tdddnlelem nsesengayl dnppkgalkk
      301 lihaaklnas lktlegernq iyiqlsevdk tkeeltehik nlqteqaslq senthfenen
      361 qklqqklkvm telyqenemk lhrkltveen yrlekeekls kvdekishat eeletyrkra
      421 kdleeelert ihsyqgqiis hekkahdnwl aarnaernln dlrkenahnr qkltetelkf
      481 ellekdpyal dvpntafgre hspygpsplg wpssetrafl spptllegpl rlspllpggg
      541 grgsrgpgnp ldhqitnerg esscdrltdp hrapsdtgsl sppwdqdrrm mfpppgqsyp
      601 dsalppqrqd rfcsnsgrls gpaelrsfnm psldkmdgsm psemessrnd tkddlgnlnv
      661 pdsslpaene atgpgfvppp lapirgplfp vdargpflrr gppfpppppg amfgasrdyf
      721 ppgdfpgppp apfamrnvyp prgfppylpp rpgffpppph segrsefpsg lippsnepat
      781 ehpepqqet
//
LOCUS       XP_016876807             789 aa            linear   PRI 05-AUG-2025
DEFINITION  melanoma inhibitory activity protein 2 isoform X16 [Homo sapiens].
ACCESSION   XP_016876807
VERSION     XP_016876807.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021318.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..789
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..789
                     /product="melanoma inhibitory activity protein 2 isoform
                     X16"
                     /calculated_mol_wt=89285
     Region          <99..429
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          394..>477
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..789
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /coded_by="XM_017021318.2:143..2512"
                     /db_xref="GeneID:4253"
                     /db_xref="HGNC:HGNC:18432"
                     /db_xref="MIM:602132"
ORIGIN      
        1 mrpdsnlygf pwelvicaav vgffavlffl wrsfrsvrsr lyvgrekkla lmlsglieek
       61 skllekfslv qkeyegyeve sslkdasfek eateaqslev enqmfvegsq iseatcekln
      121 rsnseledei lclekelkee kskhseqdel madiskriqs ledeskslks qvaeakmtfk
      181 ifqmneerlk iaikdalnen sqlqesqkql lqeaevwkeq vselnkqkvt fedskvhaeq
      241 vlndkeshik tlterllkmk dwaamlgedi tdddnlelem nsesengayl dnppkgalkk
      301 lihaaklnas lktlegernq iyiqlsevdk tkeeltehik nlqteqaslq senthfenen
      361 qklqqklkvm telyqenemk lhrkltveen yrlekeekls kvdekishat eeletyrkra
      421 kdleeelert ihsyqgqiis hekkahdnwl aarnaernln dlrkenahnr qkltetelkf
      481 ellekdpyal dvpntafgre hspygpsplg wpssetrafl spptllegpl rlspllpggg
      541 grgsrgpgnp ldhqitnerg esscdrltdp hrapsdtgsl sppwdqdrrm mfpppgqsyp
      601 dsalppqrqd rfcsnsgrls gpaelrsfnm psldkmdgsm psemessrnd tkddlgnlnv
      661 pdsslpaene atgpgfvppp lapirgplfp vdargpflrr gppfpppppg amfgasrdyf
      721 ppgdfpgppp apfamrnvyp prgfppylpp rpgffpppph segrsefpsg lippsnepat
      781 ehpepqqet
//
LOCUS       XP_016876808             789 aa            linear   PRI 05-AUG-2025
DEFINITION  melanoma inhibitory activity protein 2 isoform X16 [Homo sapiens].
ACCESSION   XP_016876808
VERSION     XP_016876808.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021319.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..789
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..789
                     /product="melanoma inhibitory activity protein 2 isoform
                     X16"
                     /calculated_mol_wt=89285
     Region          <99..429
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          394..>477
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..789
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /coded_by="XM_017021319.2:91..2460"
                     /db_xref="GeneID:4253"
                     /db_xref="HGNC:HGNC:18432"
                     /db_xref="MIM:602132"
ORIGIN      
        1 mrpdsnlygf pwelvicaav vgffavlffl wrsfrsvrsr lyvgrekkla lmlsglieek
       61 skllekfslv qkeyegyeve sslkdasfek eateaqslev enqmfvegsq iseatcekln
      121 rsnseledei lclekelkee kskhseqdel madiskriqs ledeskslks qvaeakmtfk
      181 ifqmneerlk iaikdalnen sqlqesqkql lqeaevwkeq vselnkqkvt fedskvhaeq
      241 vlndkeshik tlterllkmk dwaamlgedi tdddnlelem nsesengayl dnppkgalkk
      301 lihaaklnas lktlegernq iyiqlsevdk tkeeltehik nlqteqaslq senthfenen
      361 qklqqklkvm telyqenemk lhrkltveen yrlekeekls kvdekishat eeletyrkra
      421 kdleeelert ihsyqgqiis hekkahdnwl aarnaernln dlrkenahnr qkltetelkf
      481 ellekdpyal dvpntafgre hspygpsplg wpssetrafl spptllegpl rlspllpggg
      541 grgsrgpgnp ldhqitnerg esscdrltdp hrapsdtgsl sppwdqdrrm mfpppgqsyp
      601 dsalppqrqd rfcsnsgrls gpaelrsfnm psldkmdgsm psemessrnd tkddlgnlnv
      661 pdsslpaene atgpgfvppp lapirgplfp vdargpflrr gppfpppppg amfgasrdyf
      721 ppgdfpgppp apfamrnvyp prgfppylpp rpgffpppph segrsefpsg lippsnepat
      781 ehpepqqet
//
LOCUS       XP_047287361             784 aa            linear   PRI 05-AUG-2025
DEFINITION  melanoma inhibitory activity protein 2 isoform X17 [Homo sapiens].
ACCESSION   XP_047287361
VERSION     XP_047287361.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431405.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..784
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..784
                     /product="melanoma inhibitory activity protein 2 isoform
                     X17"
                     /calculated_mol_wt=88683
     Region          <78..424
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          389..>472
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..784
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /coded_by="XM_047431405.1:91..2445"
                     /db_xref="GeneID:4253"
                     /db_xref="HGNC:HGNC:18432"
                     /db_xref="MIM:602132"
ORIGIN      
        1 mrpdsnlygf pwelvicaav vgffavlffl wrsfrsvrsr lyvgrekkla lmlsglieek
       61 skllekfslv qkeyegyeve sslkdasfek eateaqslef vegsqiseat ceklnrsnse
      121 ledeilclek elkeekskhs eqdelmadis kriqsledes kslksqvaea kmtfkifqmn
      181 eerlkiaikd alnensqlqe sqkqllqeae vwkeqvseln kqkvtfedsk vhaeqvlndk
      241 eshiktlter llkmkdwaam lgeditdddn lelemnsese ngayldnppk galkklihaa
      301 klnaslktle gernqiyiql sevdktkeel tehiknlqte qaslqsenth fenenqklqq
      361 klkvmtelyq enemklhrkl tveenyrlek eeklskvdek ishateelet yrkrakdlee
      421 elertihsyq gqiishekka hdnwlaarna ernlndlrke nahnrqklte telkfellek
      481 dpyaldvpnt afgrehspyg psplgwpsse traflspptl legplrlspl lpggggrgsr
      541 gpgnpldhqi tnergesscd rltdphraps dtgslsppwd qdrrmmfppp gqsypdsalp
      601 pqrqdrfcsn sgrlsgpael rsfnmpsldk mdgsmpseme ssrndtkddl gnlnvpdssl
      661 paeneatgpg fvppplapir gplfpvdarg pflrrgppfp ppppgamfga srdyfppgdf
      721 pgpppapfam rnvypprgfp pylpprpgff pppphsegrs efpsglipps nepatehpep
      781 qqet
//
LOCUS       XP_047287362             780 aa            linear   PRI 05-AUG-2025
DEFINITION  melanoma inhibitory activity protein 2 isoform X18 [Homo sapiens].
ACCESSION   XP_047287362
VERSION     XP_047287362.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431406.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..780
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..780
                     /product="melanoma inhibitory activity protein 2 isoform
                     X18"
                     /calculated_mol_wt=88308
     Region          <78..420
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          385..>468
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..780
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /coded_by="XM_047431406.1:91..2433"
                     /db_xref="GeneID:4253"
                     /db_xref="HGNC:HGNC:18432"
                     /db_xref="MIM:602132"
ORIGIN      
        1 mrpdsnlygf pwelvicaav vgffavlffl wrsfrsvrsr lyvgrekkla lmlsglieek
       61 skllekfslv qkeyegyeve sslkdasfek eateaqslev enqmatcekl nrsnselede
      121 ilclekelke ekskhseqde lmadiskriq sledeskslk sqvaeakmtf kifqmneerl
      181 kiaikdalne nsqlqesqkq llqeaevwke qvselnkqkv tfedskvhae qvlndkeshi
      241 ktlterllkm kdwaamlged itdddnlele mnsesengay ldnppkgalk klihaaklna
      301 slktlegern qiyiqlsevd ktkeeltehi knlqteqasl qsenthfene nqklqqklkv
      361 mtelyqenem klhrkltvee nyrlekeekl skvdekisha teeletyrkr akdleeeler
      421 tihsyqgqii shekkahdnw laarnaernl ndlrkenahn rqkltetelk fellekdpya
      481 ldvpntafgr ehspygpspl gwpssetraf lspptllegp lrlspllpgg ggrgsrgpgn
      541 pldhqitner gesscdrltd phrapsdtgs lsppwdqdrr mmfpppgqsy pdsalppqrq
      601 drfcsnsgrl sgpaelrsfn mpsldkmdgs mpsemessrn dtkddlgnln vpdsslpaen
      661 eatgpgfvpp plapirgplf pvdargpflr rgppfppppp gamfgasrdy fppgdfpgpp
      721 papfamrnvy pprgfppylp prpgffpppp hsegrsefps glippsnepa tehpepqqet
//
LOCUS       XP_047287363             766 aa            linear   PRI 05-AUG-2025
DEFINITION  melanoma inhibitory activity protein 2 isoform X19 [Homo sapiens].
ACCESSION   XP_047287363
VERSION     XP_047287363.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431407.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..766
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..766
                     /product="melanoma inhibitory activity protein 2 isoform
                     X19"
                     /calculated_mol_wt=87003
     Region          <107..449
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          414..>497
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..766
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /coded_by="XM_047431407.1:76..2376"
                     /db_xref="GeneID:4253"
                     /db_xref="HGNC:HGNC:18432"
                     /db_xref="MIM:602132"
ORIGIN      
        1 meepgvtpqp ylgllleelr rvvaalpegm rpdsnlygfp welvicaavv gffavlfflw
       61 rsfrsvrsrl yvgrekklal mlsglieeks kllekfslvq keyegyeves slkdasfeke
      121 ateaqsleve nqmatcekln rsnseledei lclekelkee kskhseqdel madiskriqs
      181 ledeskslks qvaeakmtfk ifqmneerlk iaikdalnen sqlqesqkql lqeaevwkeq
      241 vselnkqkvt fedskvhaeq vlndkeshik tlterllkmk dwaamlgedi tdddnlelem
      301 nsesengayl dnppkgalkk lihaaklnas lktlegernq iyiqlsevdk tkeeltehik
      361 nlqteqaslq senthfenen qklqqklkvm telyqenemk lhrkltveen yrlekeekls
      421 kvdekishat eeletyrkra kdleeelert ihsyqgqiis hekkahdnwl aarnaernln
      481 dlrkenahnr qkltetelkf ellekdpyal dvpntafgrg srgpgnpldh qitnergess
      541 cdrltdphra psdtgslspp wdqdrrmmfp ppgqsypdsa lppqrqdrfc snsgrlsgpa
      601 elrsfnmpsl dkmdgsmpse messrndtkd dlgnlnvpds slpaeneatg pgfvppplap
      661 irgplfpvda rgpflrrgpp fpppppgamf gasrdyfppg dfpgpppapf amrnvypprg
      721 fppylpprpg ffpppphseg rsefpsglip psnepatehp epqqet
//
LOCUS       XP_047287364             755 aa            linear   PRI 05-AUG-2025
DEFINITION  melanoma inhibitory activity protein 2 isoform X20 [Homo sapiens].
ACCESSION   XP_047287364
VERSION     XP_047287364.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431408.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..755
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..755
                     /product="melanoma inhibitory activity protein 2 isoform
                     X20"
                     /calculated_mol_wt=85281
     Region          <101..438
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          403..>486
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..755
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /coded_by="XM_047431408.1:17..2284"
                     /db_xref="GeneID:4253"
                     /db_xref="HGNC:HGNC:18432"
                     /db_xref="MIM:602132"
ORIGIN      
        1 mtaaagfsgl pgspgvvaal pegmrpdsnl ygfpwelvic aavvgffavl fflwrsfrsv
       61 rsrlyvgrek klalmlsgli eekskllekf slvqkeyegy evesslkdas fekeateaqs
      121 leatceklnr snseledeil clekelkeek skhseqdelm adiskriqsl edeskslksq
      181 vaeakmtfki fqmneerlki aikdalnens qlqesqkqll qeaevwkeqv selnkqkvtf
      241 edskvhaeqv lndkeshikt lterllkmkd waamlgedit dddnlelemn sesengayld
      301 nppkgalkkl ihaaklnasl ktlegernqi yiqlsevdkt keeltehikn lqteqaslqs
      361 enthfenenq klqqklkvmt elyqenemkl hrkltveeny rlekeeklsk vdekishate
      421 eletyrkrak dleeelerti hsyqgqiish ekkahdnwla arnaernlnd lrkenahnrq
      481 kltetelkfe llekdpyald vpntafgrgs rgpgnpldhq itnergessc drltdphrap
      541 sdtgslsppw dqdrrmmfpp pgqsypdsal ppqrqdrfcs nsgrlsgpae lrsfnmpsld
      601 kmdgsmpsem essrndtkdd lgnlnvpdss lpaeneatgp gfvppplapi rgplfpvdar
      661 gpflrrgppf pppppgamfg asrdyfppgd fpgpppapfa mrnvypprgf ppylpprpgf
      721 fpppphsegr sefpsglipp snepatehpe pqqet
//
LOCUS       XP_047287365             754 aa            linear   PRI 05-AUG-2025
DEFINITION  melanoma inhibitory activity protein 2 isoform X21 [Homo sapiens].
ACCESSION   XP_047287365
VERSION     XP_047287365.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431409.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..754
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..754
                     /product="melanoma inhibitory activity protein 2 isoform
                     X21"
                     /calculated_mol_wt=85654
     Region          <95..437
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          402..>485
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..754
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /coded_by="XM_047431409.1:105..2369"
                     /db_xref="GeneID:4253"
                     /db_xref="HGNC:HGNC:18432"
                     /db_xref="MIM:602132"
ORIGIN      
        1 melkspeeev vaalpegmrp dsnlygfpwe lvicaavvgf favlfflwrs frsvrsrlyv
       61 grekklalml sglieekskl lekfslvqke yegyevessl kdasfekeat eaqslevenq
      121 matceklnrs nseledeilc lekelkeeks khseqdelma diskriqsle deskslksqv
      181 aeakmtfkif qmneerlkia ikdalnensq lqesqkqllq eaevwkeqvs elnkqkvtfe
      241 dskvhaeqvl ndkeshiktl terllkmkdw aamlgeditd ddnlelemns esengayldn
      301 ppkgalkkli haaklnaslk tlegernqiy iqlsevdktk eeltehiknl qteqaslqse
      361 nthfenenqk lqqklkvmte lyqenemklh rkltveenyr lekeeklskv dekishatee
      421 letyrkrakd leeelertih syqgqiishe kkahdnwlaa rnaernlndl rkenahnrqk
      481 ltetelkfel lekdpyaldv pntafgrgsr gpgnpldhqi tnergesscd rltdphraps
      541 dtgslsppwd qdrrmmfppp gqsypdsalp pqrqdrfcsn sgrlsgpael rsfnmpsldk
      601 mdgsmpseme ssrndtkddl gnlnvpdssl paeneatgpg fvppplapir gplfpvdarg
      661 pflrrgppfp ppppgamfga srdyfppgdf pgpppapfam rnvypprgfp pylpprpgff
      721 pppphsegrs efpsglipps nepatehpep qqet
//
LOCUS       XP_016876812             738 aa            linear   PRI 05-AUG-2025
DEFINITION  melanoma inhibitory activity protein 2 isoform X22 [Homo sapiens].
ACCESSION   XP_016876812
VERSION     XP_016876812.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021323.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..738
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..738
                     /product="melanoma inhibitory activity protein 2 isoform
                     X22"
                     /calculated_mol_wt=83289
     Region          <48..378
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          343..>426
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..738
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /coded_by="XM_017021323.2:206..2422"
                     /db_xref="GeneID:4253"
                     /db_xref="HGNC:HGNC:18432"
                     /db_xref="MIM:602132"
ORIGIN      
        1 mlsglieeks kllekfslvq keyegyeves slkdasfeke ateaqsleve nqmfvegsqi
       61 seatceklnr snseledeil clekelkeek skhseqdelm adiskriqsl edeskslksq
      121 vaeakmtfki fqmneerlki aikdalnens qlqesqkqll qeaevwkeqv selnkqkvtf
      181 edskvhaeqv lndkeshikt lterllkmkd waamlgedit dddnlelemn sesengayld
      241 nppkgalkkl ihaaklnasl ktlegernqi yiqlsevdkt keeltehikn lqteqaslqs
      301 enthfenenq klqqklkvmt elyqenemkl hrkltveeny rlekeeklsk vdekishate
      361 eletyrkrak dleeelerti hsyqgqiish ekkahdnwla arnaernlnd lrkenahnrq
      421 kltetelkfe llekdpyald vpntafgreh spygpsplgw pssetrafls pptllegplr
      481 lspllpgggg rgsrgpgnpl dhqitnerge sscdrltdph rapsdtgsls ppwdqdrrmm
      541 fpppgqsypd salppqrqdr fcsnsgrlsg paelrsfnmp sldkmdgsmp semessrndt
      601 kddlgnlnvp dsslpaenea tgpgfvpppl apirgplfpv dargpflrrg ppfpppppga
      661 mfgasrdyfp pgdfpgpppa pfamrnvypp rgfppylppr pgffpppphs egrsefpsgl
      721 ippsnepate hpepqqet
//
LOCUS       XP_016876813             738 aa            linear   PRI 05-AUG-2025
DEFINITION  melanoma inhibitory activity protein 2 isoform X22 [Homo sapiens].
ACCESSION   XP_016876813
VERSION     XP_016876813.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021324.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..738
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..738
                     /product="melanoma inhibitory activity protein 2 isoform
                     X22"
                     /calculated_mol_wt=83289
     Region          <48..378
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          343..>426
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..738
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /coded_by="XM_017021324.3:199..2415"
                     /db_xref="GeneID:4253"
                     /db_xref="HGNC:HGNC:18432"
                     /db_xref="MIM:602132"
ORIGIN      
        1 mlsglieeks kllekfslvq keyegyeves slkdasfeke ateaqsleve nqmfvegsqi
       61 seatceklnr snseledeil clekelkeek skhseqdelm adiskriqsl edeskslksq
      121 vaeakmtfki fqmneerlki aikdalnens qlqesqkqll qeaevwkeqv selnkqkvtf
      181 edskvhaeqv lndkeshikt lterllkmkd waamlgedit dddnlelemn sesengayld
      241 nppkgalkkl ihaaklnasl ktlegernqi yiqlsevdkt keeltehikn lqteqaslqs
      301 enthfenenq klqqklkvmt elyqenemkl hrkltveeny rlekeeklsk vdekishate
      361 eletyrkrak dleeelerti hsyqgqiish ekkahdnwla arnaernlnd lrkenahnrq
      421 kltetelkfe llekdpyald vpntafgreh spygpsplgw pssetrafls pptllegplr
      481 lspllpgggg rgsrgpgnpl dhqitnerge sscdrltdph rapsdtgsls ppwdqdrrmm
      541 fpppgqsypd salppqrqdr fcsnsgrlsg paelrsfnmp sldkmdgsmp semessrndt
      601 kddlgnlnvp dsslpaenea tgpgfvpppl apirgplfpv dargpflrrg ppfpppppga
      661 mfgasrdyfp pgdfpgpppa pfamrnvypp rgfppylppr pgffpppphs egrsefpsgl
      721 ippsnepate hpepqqet
//
LOCUS       XP_024305366             738 aa            linear   PRI 05-AUG-2025
DEFINITION  melanoma inhibitory activity protein 2 isoform X22 [Homo sapiens].
ACCESSION   XP_024305366
VERSION     XP_024305366.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449598.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..738
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..738
                     /product="melanoma inhibitory activity protein 2 isoform
                     X22"
                     /calculated_mol_wt=83289
     Region          <48..378
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          343..>426
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..738
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /coded_by="XM_024449598.2:298..2514"
                     /db_xref="GeneID:4253"
                     /db_xref="HGNC:HGNC:18432"
                     /db_xref="MIM:602132"
ORIGIN      
        1 mlsglieeks kllekfslvq keyegyeves slkdasfeke ateaqsleve nqmfvegsqi
       61 seatceklnr snseledeil clekelkeek skhseqdelm adiskriqsl edeskslksq
      121 vaeakmtfki fqmneerlki aikdalnens qlqesqkqll qeaevwkeqv selnkqkvtf
      181 edskvhaeqv lndkeshikt lterllkmkd waamlgedit dddnlelemn sesengayld
      241 nppkgalkkl ihaaklnasl ktlegernqi yiqlsevdkt keeltehikn lqteqaslqs
      301 enthfenenq klqqklkvmt elyqenemkl hrkltveeny rlekeeklsk vdekishate
      361 eletyrkrak dleeelerti hsyqgqiish ekkahdnwla arnaernlnd lrkenahnrq
      421 kltetelkfe llekdpyald vpntafgreh spygpsplgw pssetrafls pptllegplr
      481 lspllpgggg rgsrgpgnpl dhqitnerge sscdrltdph rapsdtgsls ppwdqdrrmm
      541 fpppgqsypd salppqrqdr fcsnsgrlsg paelrsfnmp sldkmdgsmp semessrndt
      601 kddlgnlnvp dsslpaenea tgpgfvpppl apirgplfpv dargpflrrg ppfpppppga
      661 mfgasrdyfp pgdfpgpppa pfamrnvypp rgfppylppr pgffpppphs egrsefpsgl
      721 ippsnepate hpepqqet
//
LOCUS       XP_047287366             738 aa            linear   PRI 05-AUG-2025
DEFINITION  melanoma inhibitory activity protein 2 isoform X22 [Homo sapiens].
ACCESSION   XP_047287366
VERSION     XP_047287366.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431410.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..738
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..738
                     /product="melanoma inhibitory activity protein 2 isoform
                     X22"
                     /calculated_mol_wt=83289
     Region          <48..378
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          343..>426
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..738
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /coded_by="XM_047431410.1:134..2350"
                     /db_xref="GeneID:4253"
                     /db_xref="HGNC:HGNC:18432"
                     /db_xref="MIM:602132"
ORIGIN      
        1 mlsglieeks kllekfslvq keyegyeves slkdasfeke ateaqsleve nqmfvegsqi
       61 seatceklnr snseledeil clekelkeek skhseqdelm adiskriqsl edeskslksq
      121 vaeakmtfki fqmneerlki aikdalnens qlqesqkqll qeaevwkeqv selnkqkvtf
      181 edskvhaeqv lndkeshikt lterllkmkd waamlgedit dddnlelemn sesengayld
      241 nppkgalkkl ihaaklnasl ktlegernqi yiqlsevdkt keeltehikn lqteqaslqs
      301 enthfenenq klqqklkvmt elyqenemkl hrkltveeny rlekeeklsk vdekishate
      361 eletyrkrak dleeelerti hsyqgqiish ekkahdnwla arnaernlnd lrkenahnrq
      421 kltetelkfe llekdpyald vpntafgreh spygpsplgw pssetrafls pptllegplr
      481 lspllpgggg rgsrgpgnpl dhqitnerge sscdrltdph rapsdtgsls ppwdqdrrmm
      541 fpppgqsypd salppqrqdr fcsnsgrlsg paelrsfnmp sldkmdgsmp semessrndt
      601 kddlgnlnvp dsslpaenea tgpgfvpppl apirgplfpv dargpflrrg ppfpppppga
      661 mfgasrdyfp pgdfpgpppa pfamrnvypp rgfppylppr pgffpppphs egrsefpsgl
      721 ippsnepate hpepqqet
//
LOCUS       XP_047287367             732 aa            linear   PRI 05-AUG-2025
DEFINITION  melanoma inhibitory activity protein 2 isoform X23 [Homo sapiens].
ACCESSION   XP_047287367
VERSION     XP_047287367.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431411.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..732
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..732
                     /product="melanoma inhibitory activity protein 2 isoform
                     X23"
                     /calculated_mol_wt=83242
     Region          <78..415
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          380..>463
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..732
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /coded_by="XM_047431411.1:91..2289"
                     /db_xref="GeneID:4253"
                     /db_xref="HGNC:HGNC:18432"
                     /db_xref="MIM:602132"
ORIGIN      
        1 mrpdsnlygf pwelvicaav vgffavlffl wrsfrsvrsr lyvgrekkla lmlsglieek
       61 skllekfslv qkeyegyeve sslkdasfek eateaqslea tceklnrsns eledeilcle
      121 kelkeekskh seqdelmadi skriqslede skslksqvae akmtfkifqm neerlkiaik
      181 dalnensqlq esqkqllqea evwkeqvsel nkqkvtfeds kvhaeqvlnd keshiktlte
      241 rllkmkdwaa mlgeditddd nlelemnses engayldnpp kgalkkliha aklnaslktl
      301 egernqiyiq lsevdktkee ltehiknlqt eqaslqsent hfenenqklq qklkvmtely
      361 qenemklhrk ltveenyrle keeklskvde kishateele tyrkrakdle eelertihsy
      421 qgqiishekk ahdnwlaarn aernlndlrk enahnrqklt etelkfelle kdpyaldvpn
      481 tafgrgsrgp gnpldhqitn ergesscdrl tdphrapsdt gslsppwdqd rrmmfpppgq
      541 sypdsalppq rqdrfcsnsg rlsgpaelrs fnmpsldkmd gsmpsemess rndtkddlgn
      601 lnvpdsslpa eneatgpgfv ppplapirgp lfpvdargpf lrrgppfppp ppgamfgasr
      661 dyfppgdfpg pppapfamrn vypprgfppy lpprpgffpp pphsegrsef psglippsne
      721 patehpepqq et
//
LOCUS       XP_047287368             579 aa            linear   PRI 05-AUG-2025
DEFINITION  melanoma inhibitory activity protein 2 isoform X24 [Homo sapiens].
ACCESSION   XP_047287368
VERSION     XP_047287368.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431412.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..579
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..579
                     /product="melanoma inhibitory activity protein 2 isoform
                     X24"
                     /calculated_mol_wt=66645
     Region          <107..444
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..579
                     /gene="MIA2"
                     /gene_synonym="CTAGE5; MEA6; MGEA; MGEA11; MGEA6; TALI"
                     /coded_by="XM_047431412.1:76..1815"
                     /db_xref="GeneID:4253"
                     /db_xref="HGNC:HGNC:18432"
                     /db_xref="MIM:602132"
ORIGIN      
        1 meepgvtpqp ylgllleelr rvvaalpegm rpdsnlygfp welvicaavv gffavlfflw
       61 rsfrsvrsrl yvgrekklal mlsglieeks kllekfslvq keyegyeves slkdasfeke
      121 ateaqsleat ceklnrsnse ledeilclek elkeekskhs eqdelmadis kriqsledes
      181 kslksqvaea kmtfkifqmn eerlkiaikd alnensqlqe sqkqllqeae vwkeqvseln
      241 kqkvtfedsk vhaeqvlndk eshiktlter llkmkdwaam lgeditdddn lelemnsese
      301 ngayldnppk galkklihaa klnaslktle gernqiyiql sevdktkeel tehiknlqte
      361 qaslqsenth fenenqklqq klkvmtelyq enemklhrkl tveenyrlek eeklskvdek
      421 ishateelet yrkrakdlee elertihsyq gqiishekka hdnwlaarna ernlndlrke
      481 nahnrqklte telkfellek dpyaldvpnt afgrehspyg psplgwpsse traflspptl
      541 legplrlspl lpggggrdel slnddlhifc fpsllllms
//
LOCUS       XP_011535090            1166 aa            linear   PRI 05-AUG-2025
DEFINITION  mitogen-activated protein kinase kinase kinase 9 isoform X1 [Homo
            sapiens].
ACCESSION   XP_011535090
VERSION     XP_011535090.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536788.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1166
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1166
                     /product="mitogen-activated protein kinase kinase kinase 9
                     isoform X1"
                     /calculated_mol_wt=128583
     Region          56..113
                     /region_name="SH3_MLK1-3"
                     /note="Src Homology 3 domain of Mixed Lineage Kinases 1,
                     2, and 3; cd12059"
                     /db_xref="CDD:212992"
     Site            order(61,63,66,70,93..94,107,109..110)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212992"
     Region          137..406
                     /region_name="STKc_MLK1"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     Mixed Lineage Kinase 1; cd14145"
                     /db_xref="CDD:271047"
     Site            order(150..154,158,169,171,204,220..223,227,229,268,270,
                     272..273,275,294,297,311..314)
                     /site_type="active"
                     /db_xref="CDD:271047"
     Site            order(150..154,158,169,171,204,220..223,227,268,270,
                     272..273,275,294)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271047"
     Site            order(154,227,229,268,270,272,297,311..314)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:271047"
     Site            293..314
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:271047"
     CDS             1..1166
                     /gene="MAP3K9"
                     /gene_synonym="MEKK9; MLK1; PRKE1"
                     /coded_by="XM_011536788.4:343..3843"
                     /db_xref="GeneID:4293"
                     /db_xref="HGNC:HGNC:6861"
                     /db_xref="MIM:600136"
ORIGIN      
        1 mepsrallgc lasaaaaapp gedgagagae eeeeeeeeaa aavgpgelgc daplpywtav
       61 feyeaagede ltlrlgdvve vlskdsqvsg degwwtgqln qrvgifpsny vtprsafssr
      121 cqpggedpsc yppiqlleid faeltleeii giggfgkvyr afwigdevav kaarhdpded
      181 isqtienvrq eaklfamlkh pniialrgvc lkepnlclvm efarggplnr vlsgkrippd
      241 ilvnwavqia rgmnylhdea ivpiihrdlk ssnililqkv engdlsnkil kitdfglare
      301 whrttkmsaa gtyawmapev irasmfskgs dvwsygvllw elltgevpfr gidglavayg
      361 vamnklalpi pstcpepfak lmedcwnpdp hsrpsftnil dqlttieesg ffempkdsfh
      421 clqdnwkhei qemfdqlrak ekelrtweee ltraalqqkn qeellrrreq elaereidil
      481 erelniiihq lcqekprvkk rkgkfrksrl klkdgnrisl psdfqhkftv qasptmdkrk
      541 slinsrsspp asptiiprlr aiqcetvsqi swgqntqghl spalsshrlv qacsihnfch
      601 lsstmciymh iltpgesskt wgrssvvpke egeeeekrap kkkgrtwgpg tlgqkelasg
      661 degspqrrek anglstpses phfhlglksl vdgykqwsss apnlvkgprs spalpgftsl
      721 memallaasw vvpidieede dsegpgsges rlqhspsqsy lcipfprged gdgpssdgih
      781 eeptpvnsat stpqltptns lkrggahhrr cevallgcga vlaatglgfd lleagkcqll
      841 pleepeppar eekkrreglf qrssrprrst sppsrklfkk eepmlllgdp sasltllsls
      901 sisecnstrs llrsdsdeiv vyempvspve applspcthn plvnvrverf krdpnqsltp
      961 thvtlttpsq psshrrtpsd galkpetlla srspssngls pspgagmlkt pspsrdpgef
     1021 prlpdpnvvf pptprrwntq qdstlerpkt leflprprps anrqrldpww fvspsharst
     1081 spanssstet psnldscfas ssstveerpg lpallpfqag plpptertll dldaegqsqd
     1141 stvplcrael nthrpapyei qqefws
//
LOCUS       XP_005267740            1081 aa            linear   PRI 05-AUG-2025
DEFINITION  mitogen-activated protein kinase kinase kinase 9 isoform X2 [Homo
            sapiens].
ACCESSION   XP_005267740
VERSION     XP_005267740.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267683.6
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1081
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1081
                     /product="mitogen-activated protein kinase kinase kinase 9
                     isoform X2"
                     /calculated_mol_wt=119249
     Region          56..113
                     /region_name="SH3_MLK1-3"
                     /note="Src Homology 3 domain of Mixed Lineage Kinases 1,
                     2, and 3; cd12059"
                     /db_xref="CDD:212992"
     Site            order(61,63,66,70,93..94,107,109..110)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212992"
     Region          137..406
                     /region_name="STKc_MLK1"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     Mixed Lineage Kinase 1; cd14145"
                     /db_xref="CDD:271047"
     Site            order(150..154,158,169,171,204,220..223,227,229,268,270,
                     272..273,275,294,297,311..314)
                     /site_type="active"
                     /db_xref="CDD:271047"
     Site            order(150..154,158,169,171,204,220..223,227,268,270,
                     272..273,275,294)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271047"
     Site            order(154,227,229,268,270,272,297,311..314)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:271047"
     Site            293..314
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:271047"
     CDS             1..1081
                     /gene="MAP3K9"
                     /gene_synonym="MEKK9; MLK1; PRKE1"
                     /coded_by="XM_005267683.6:343..3588"
                     /db_xref="GeneID:4293"
                     /db_xref="HGNC:HGNC:6861"
                     /db_xref="MIM:600136"
ORIGIN      
        1 mepsrallgc lasaaaaapp gedgagagae eeeeeeeeaa aavgpgelgc daplpywtav
       61 feyeaagede ltlrlgdvve vlskdsqvsg degwwtgqln qrvgifpsny vtprsafssr
      121 cqpggedpsc yppiqlleid faeltleeii giggfgkvyr afwigdevav kaarhdpded
      181 isqtienvrq eaklfamlkh pniialrgvc lkepnlclvm efarggplnr vlsgkrippd
      241 ilvnwavqia rgmnylhdea ivpiihrdlk ssnililqkv engdlsnkil kitdfglare
      301 whrttkmsaa gtyawmapev irasmfskgs dvwsygvllw elltgevpfr gidglavayg
      361 vamnklalpi pstcpepfak lmedcwnpdp hsrpsftnil dqlttieesg ffempkdsfh
      421 clqdnwkhei qemfdqlrak ekelrtweee ltraalqqkn qeellrrreq elaereidil
      481 erelniiihq lcqekprvkk rkgkfrksrl klkdgnrisl psdfqhkftv qasptmdkrk
      541 slinsrsspp asptiiprlr aiqltpgess ktwgrssvvp keegeeeekr apkkkgrtwg
      601 pgtlgqkela sgdeglkslv dgykqwsssa pnlvkgprss palpgftslm emededsegp
      661 gsgesrlqhs psqsylcipf prgedgdgps sdgiheeptp vnsatstpql tptnslkrgg
      721 ahhrrceval lgcgavlaat glgfdlleag kcqllpleep eppareekkr reglfqrssr
      781 prrstsppsr klfkkeepml llgdpsaslt llslssisec nstrsllrsd sdeivvyemp
      841 vspveappls pcthnplvnv rverfkrdpn qsltpthvtl ttpsqpsshr rtpsdgalkp
      901 etllasrsps snglspspga gmlktpspsr dpgefprlpd pnvvfpptpr rwntqqdstl
      961 erpktleflp rprpsanrqr ldpwwfvsps harstspans sstetpsnld scfasssstv
     1021 eerpglpall pfqagplppt ertlldldae gqsqdstvpl craelnthrp apyeiqqefw
     1081 s
//
LOCUS       XP_011535094             860 aa            linear   PRI 05-AUG-2025
DEFINITION  mitogen-activated protein kinase kinase kinase 9 isoform X3 [Homo
            sapiens].
ACCESSION   XP_011535094
VERSION     XP_011535094.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536792.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..860
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..860
                     /product="mitogen-activated protein kinase kinase kinase 9
                     isoform X3"
                     /calculated_mol_wt=95211
     Region          <1..100
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Region          <121..>205
                     /region_name="COG2433"
                     /note="Possible nuclease of RNase H fold, RuvC/YqgF family
                     [General function prediction only]"
                     /db_xref="CDD:441980"
     Region          <620..>797
                     /region_name="DUF2967"
                     /note="Protein of unknown function (DUF2967); pfam11179"
                     /db_xref="CDD:402654"
     CDS             1..860
                     /gene="MAP3K9"
                     /gene_synonym="MEKK9; MLK1; PRKE1"
                     /coded_by="XM_011536792.1:329..2911"
                     /db_xref="GeneID:4293"
                     /db_xref="HGNC:HGNC:6861"
                     /db_xref="MIM:600136"
ORIGIN      
        1 msaagtyawm apevirasmf skgsdvwsyg vllwelltge vpfrgidgla vaygvamnkl
       61 alpipstcpe pfaklmedcw npdphsrpsf tnildqltti eesgffempk dsfhclqdnw
      121 kheiqemfdq lrakekelrt weeeltraal qqknqeellr rreqelaere idilerelni
      181 iihqlcqekp rvkkrkgkfr ksrlklkdgn rislpsdfqh kftvqasptm dkrkslinsr
      241 ssppasptii prlraiqcet vsqiswgqnt qghlspalss hrlvqacsih nfchlsstmc
      301 iymhiltpge ssktwgrssv vpkeegeeee krapkkkgrt wgpgtlgqke lasgdegspq
      361 rrekanglst psesphfhlg lkslvdgykq wsssapnlvk gprsspalpg ftslmemall
      421 aaswvvpidi eededsegpg sgesrlqhsp sqsylcipfp rgedgdgpss dgiheeptpv
      481 nsatstpqlt ptnslkrgga hhrrcevall gcgavlaatg lgfdlleagk cqllpleepe
      541 ppareekkrr eglfqrssrp rrstsppsrk lfkkeepmll lgdpsasltl lslssisecn
      601 strsllrsds deivvyempv spveapplsp cthnplvnvr verfkrdpnq sltpthvtlt
      661 tpsqpsshrr tpsdgalkpe tllasrspss nglspspgag mlktpspsrd pgefprlpdp
      721 nvvfpptprr wntqqdstle rpktleflpr prpsanrqrl dpwwfvspsh arstspanss
      781 stetpsnlds cfasssstve erpglpallp fqagplppte rtlldldaeg qsqdstvplc
      841 raelnthrpa pyeiqqefws
//
LOCUS       XP_011535096             804 aa            linear   PRI 05-AUG-2025
DEFINITION  mitogen-activated protein kinase kinase kinase 9 isoform X4 [Homo
            sapiens].
ACCESSION   XP_011535096
VERSION     XP_011535096.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536794.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..804
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..804
                     /product="mitogen-activated protein kinase kinase kinase 9
                     isoform X4"
                     /calculated_mol_wt=89230
     Region          <1..44
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Region          <65..>149
                     /region_name="COG2433"
                     /note="Possible nuclease of RNase H fold, RuvC/YqgF family
                     [General function prediction only]"
                     /db_xref="CDD:441980"
     Region          <564..>741
                     /region_name="DUF2967"
                     /note="Protein of unknown function (DUF2967); pfam11179"
                     /db_xref="CDD:402654"
     CDS             1..804
                     /gene="MAP3K9"
                     /gene_synonym="MEKK9; MLK1; PRKE1"
                     /coded_by="XM_011536794.3:6010..8424"
                     /db_xref="GeneID:4293"
                     /db_xref="HGNC:HGNC:6861"
                     /db_xref="MIM:600136"
ORIGIN      
        1 mnklalpips tcpepfaklm edcwnpdphs rpsftnildq lttieesgff empkdsfhcl
       61 qdnwkheiqe mfdqlrakek elrtweeelt raalqqknqe ellrrreqel aereidiler
      121 elniiihqlc qekprvkkrk gkfrksrlkl kdgnrislps dfqhkftvqa sptmdkrksl
      181 insrssppas ptiiprlrai qcetvsqisw gqntqghlsp alsshrlvqa csihnfchls
      241 stmciymhil tpgessktwg rssvvpkeeg eeeekrapkk kgrtwgpgtl gqkelasgde
      301 gspqrrekan glstpsesph fhlglkslvd gykqwsssap nlvkgprssp alpgftslme
      361 mallaaswvv pidieededs egpgsgesrl qhspsqsylc ipfprgedgd gpssdgihee
      421 ptpvnsatst pqltptnslk rggahhrrce vallgcgavl aatglgfdll eagkcqllpl
      481 eepepparee kkrreglfqr ssrprrstsp psrklfkkee pmlllgdpsa sltllslssi
      541 secnstrsll rsdsdeivvy empvspveap plspcthnpl vnvrverfkr dpnqsltpth
      601 vtlttpsqps shrrtpsdga lkpetllasr spssnglsps pgagmlktps psrdpgefpr
      661 lpdpnvvfpp tprrwntqqd stlerpktle flprprpsan rqrldpwwfv spsharstsp
      721 anssstetps nldscfasss stveerpglp allpfqagpl pptertlldl daegqsqdst
      781 vplcraelnt hrpapyeiqq efws
//
LOCUS       XP_016876821             294 aa            linear   PRI 05-AUG-2025
DEFINITION  CDK-activating kinase assembly factor MAT1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_016876821
VERSION     XP_016876821.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021332.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..294
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..294
                     /product="CDK-activating kinase assembly factor MAT1
                     isoform X1"
                     /calculated_mol_wt=33902
     Region          16..294
                     /region_name="cdk7"
                     /note="CDK-activating kinase assembly factor MAT1;
                     TIGR00570"
                     /db_xref="CDD:129661"
     CDS             1..294
                     /gene="MNAT1"
                     /gene_synonym="CAP35; MAT1; RNF66; TFB3"
                     /coded_by="XM_017021332.3:336..1220"
                     /db_xref="GeneID:4331"
                     /db_xref="HGNC:HGNC:7181"
                     /db_xref="MIM:602659"
ORIGIN      
        1 mqirscsvaq tgvhccescv dllfvrgagn cpecgtplrk snfrvqlfed ptvdkeveir
       61 kkvlkiynkr eedfpslrey ndfleeveei vfnltnnvdl dntkkkmeiy qkenkdviqk
      121 nklkltreqe eleealever qeneqrrlfi qkeeqlqqil krknkqafld elessdlpva
      181 lllaqhkdrs tqlemqlekp kpvkpvtfst gikmgqhisl apihkleeal yeyqplqiet
      241 ygphvpelem lgrlgylnhv raaspqdlag gytsslachr alqdafsglf wqps
//
LOCUS       XP_005267745             278 aa            linear   PRI 05-AUG-2025
DEFINITION  CDK-activating kinase assembly factor MAT1 isoform X2 [Homo
            sapiens].
ACCESSION   XP_005267745
VERSION     XP_005267745.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267688.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..278
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..278
                     /product="CDK-activating kinase assembly factor MAT1
                     isoform X2"
                     /calculated_mol_wt=32320
     Region          1..272
                     /region_name="cdk7"
                     /note="CDK-activating kinase assembly factor MAT1;
                     TIGR00570"
                     /db_xref="CDD:129661"
     CDS             1..278
                     /gene="MNAT1"
                     /gene_synonym="CAP35; MAT1; RNF66; TFB3"
                     /coded_by="XM_005267688.4:103..939"
                     /db_xref="GeneID:4331"
                     /db_xref="HGNC:HGNC:7181"
                     /db_xref="MIM:602659"
ORIGIN      
        1 mddqgcprck ttkyrnpslk lmvnvcghtl cescvdllfv rgagncpecg tplrksnfrv
       61 qlfedptvdk eveirkkvlk iynkreedfp slreyndfle eveeivfnlt nnvdldntkk
      121 kmeiyqkenk dviqknklkl treqeeleea leverqeneq rrlfiqkeeq lqqilkrknk
      181 qafldeless dlpvalllaq hkdrstqlem qlekpkpvkp vtfstgikmg qhislapihk
      241 leealyeyqp lqietygphv pelemlgrlg gfdtisli
//
LOCUS       XP_016876823             188 aa            linear   PRI 05-AUG-2025
DEFINITION  CDK-activating kinase assembly factor MAT1 isoform X3 [Homo
            sapiens].
ACCESSION   XP_016876823
VERSION     XP_016876823.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021334.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..188
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..188
                     /product="CDK-activating kinase assembly factor MAT1
                     isoform X3"
                     /calculated_mol_wt=21645
     Region          <1..188
                     /region_name="cdk7"
                     /note="CDK-activating kinase assembly factor MAT1;
                     TIGR00570"
                     /db_xref="CDD:129661"
     CDS             1..188
                     /gene="MNAT1"
                     /gene_synonym="CAP35; MAT1; RNF66; TFB3"
                     /coded_by="XM_017021334.3:678..1244"
                     /db_xref="GeneID:4331"
                     /db_xref="HGNC:HGNC:7181"
                     /db_xref="MIM:602659"
ORIGIN      
        1 meiyqkenkd viqknklklt reqeeleeal everqeneqr rlfiqkeeql qqilkrknkq
       61 afldelessd lpvalllaqh kdrstqlemq lekpkpvkpv tfstgikmgq hislapihkl
      121 eealyeyqpl qietygphvp elemlgrlgy lnhvraaspq dlaggytssl achralqdaf
      181 sglfwqps
//
LOCUS       XP_047287369             188 aa            linear   PRI 05-AUG-2025
DEFINITION  CDK-activating kinase assembly factor MAT1 isoform X3 [Homo
            sapiens].
ACCESSION   XP_047287369
VERSION     XP_047287369.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431413.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..188
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..188
                     /product="CDK-activating kinase assembly factor MAT1
                     isoform X3"
                     /calculated_mol_wt=21645
     Region          <1..188
                     /region_name="cdk7"
                     /note="CDK-activating kinase assembly factor MAT1;
                     TIGR00570"
                     /db_xref="CDD:129661"
     CDS             1..188
                     /gene="MNAT1"
                     /gene_synonym="CAP35; MAT1; RNF66; TFB3"
                     /coded_by="XM_047431413.1:248..814"
                     /db_xref="GeneID:4331"
                     /db_xref="HGNC:HGNC:7181"
                     /db_xref="MIM:602659"
ORIGIN      
        1 meiyqkenkd viqknklklt reqeeleeal everqeneqr rlfiqkeeql qqilkrknkq
       61 afldelessd lpvalllaqh kdrstqlemq lekpkpvkpv tfstgikmgq hislapihkl
      121 eealyeyqpl qietygphvp elemlgrlgy lnhvraaspq dlaggytssl achralqdaf
      181 sglfwqps
//
LOCUS       XP_024305368             243 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 196 isoform X1 [Homo
            sapiens].
ACCESSION   XP_024305368
VERSION     XP_024305368.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449600.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..243
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..243
                     /product="coiled-coil domain-containing protein 196
                     isoform X1"
                     /calculated_mol_wt=28343
     Region          24..>112
                     /region_name="PRK12704"
                     /note="phosphodiesterase; Provisional"
                     /db_xref="CDD:237177"
     Region          <27..216
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     CDS             1..243
                     /gene="CCDC196"
                     /gene_synonym="C14orf53; LINC00238; NCRNA00238"
                     /coded_by="XM_024449600.2:133..864"
                     /db_xref="GeneID:440184"
                     /db_xref="HGNC:HGNC:20100"
ORIGIN      
        1 mtsganssgs ylpseirssk iddnylkeln edlklrkqel lemlkpledk nnllfqklms
       61 nleekqrslq imrqimagkg ceessvmell keaeemkqnl erknkmlrke memlwnktfe
      121 aeelsdqqka pqtknkadlq dgkapkspss prkteselek sfaekvkeir kekqqrkmew
      181 vkyqeqnnil qndfhgkvie lriealknyq kandlklsly lqqnfepmqa flnlpgsqgi
      241 riv
//
LOCUS       XP_024305369             243 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 196 isoform X1 [Homo
            sapiens].
ACCESSION   XP_024305369
VERSION     XP_024305369.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449601.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..243
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..243
                     /product="coiled-coil domain-containing protein 196
                     isoform X1"
                     /calculated_mol_wt=28343
     Region          24..>112
                     /region_name="PRK12704"
                     /note="phosphodiesterase; Provisional"
                     /db_xref="CDD:237177"
     Region          <27..216
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     CDS             1..243
                     /gene="CCDC196"
                     /gene_synonym="C14orf53; LINC00238; NCRNA00238"
                     /coded_by="XM_024449601.2:133..864"
                     /db_xref="GeneID:440184"
                     /db_xref="HGNC:HGNC:20100"
ORIGIN      
        1 mtsganssgs ylpseirssk iddnylkeln edlklrkqel lemlkpledk nnllfqklms
       61 nleekqrslq imrqimagkg ceessvmell keaeemkqnl erknkmlrke memlwnktfe
      121 aeelsdqqka pqtknkadlq dgkapkspss prkteselek sfaekvkeir kekqqrkmew
      181 vkyqeqnnil qndfhgkvie lriealknyq kandlklsly lqqnfepmqa flnlpgsqgi
      241 riv
//
LOCUS       XP_024305370             243 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 196 isoform X1 [Homo
            sapiens].
ACCESSION   XP_024305370
VERSION     XP_024305370.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449602.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..243
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..243
                     /product="coiled-coil domain-containing protein 196
                     isoform X1"
                     /calculated_mol_wt=28343
     Region          24..>112
                     /region_name="PRK12704"
                     /note="phosphodiesterase; Provisional"
                     /db_xref="CDD:237177"
     Region          <27..216
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     CDS             1..243
                     /gene="CCDC196"
                     /gene_synonym="C14orf53; LINC00238; NCRNA00238"
                     /coded_by="XM_024449602.2:133..864"
                     /db_xref="GeneID:440184"
                     /db_xref="HGNC:HGNC:20100"
ORIGIN      
        1 mtsganssgs ylpseirssk iddnylkeln edlklrkqel lemlkpledk nnllfqklms
       61 nleekqrslq imrqimagkg ceessvmell keaeemkqnl erknkmlrke memlwnktfe
      121 aeelsdqqka pqtknkadlq dgkapkspss prkteselek sfaekvkeir kekqqrkmew
      181 vkyqeqnnil qndfhgkvie lriealknyq kandlklsly lqqnfepmqa flnlpgsqgi
      241 riv
//
LOCUS       XP_047287370             243 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 196 isoform X1 [Homo
            sapiens].
ACCESSION   XP_047287370
VERSION     XP_047287370.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431414.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..243
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..243
                     /product="coiled-coil domain-containing protein 196
                     isoform X1"
                     /calculated_mol_wt=28343
     Region          24..>112
                     /region_name="PRK12704"
                     /note="phosphodiesterase; Provisional"
                     /db_xref="CDD:237177"
     Region          <27..216
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     CDS             1..243
                     /gene="CCDC196"
                     /gene_synonym="C14orf53; LINC00238; NCRNA00238"
                     /coded_by="XM_047431414.1:133..864"
                     /db_xref="GeneID:440184"
                     /db_xref="HGNC:HGNC:20100"
ORIGIN      
        1 mtsganssgs ylpseirssk iddnylkeln edlklrkqel lemlkpledk nnllfqklms
       61 nleekqrslq imrqimagkg ceessvmell keaeemkqnl erknkmlrke memlwnktfe
      121 aeelsdqqka pqtknkadlq dgkapkspss prkteselek sfaekvkeir kekqqrkmew
      181 vkyqeqnnil qndfhgkvie lriealknyq kandlklsly lqqnfepmqa flnlpgsqgi
      241 riv
//
LOCUS       XP_024305372             241 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 196 isoform X2 [Homo
            sapiens].
ACCESSION   XP_024305372
VERSION     XP_024305372.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449604.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..241
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..241
                     /product="coiled-coil domain-containing protein 196
                     isoform X2"
                     /calculated_mol_wt=28119
     Region          24..>112
                     /region_name="PRK12704"
                     /note="phosphodiesterase; Provisional"
                     /db_xref="CDD:237177"
     Region          <27..216
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     CDS             1..241
                     /gene="CCDC196"
                     /gene_synonym="C14orf53; LINC00238; NCRNA00238"
                     /coded_by="XM_024449604.2:133..858"
                     /db_xref="GeneID:440184"
                     /db_xref="HGNC:HGNC:20100"
ORIGIN      
        1 mtsganssgs ylpseirssk iddnylkeln edlklrkqel lemlkpledk nnllfqklms
       61 nleekqrslq imrqimagkg ceessvmell keaeemkqnl erknkmlrke memlwnktfe
      121 aeelsdqqka pqtknkadlq dgkapkspss prkteselek sfaekvkeir kekqqrkmew
      181 vkyqeqnnil qndfhgkvie lriealknyq kandlklsly lqqnfepmqa flnlpgsqaf
      241 p
//
LOCUS       XP_024305373             240 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 196 isoform X3 [Homo
            sapiens].
ACCESSION   XP_024305373
VERSION     XP_024305373.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449605.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..240
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..240
                     /product="coiled-coil domain-containing protein 196
                     isoform X3"
                     /calculated_mol_wt=28003
     Region          24..>112
                     /region_name="PRK12704"
                     /note="phosphodiesterase; Provisional"
                     /db_xref="CDD:237177"
     CDS             1..240
                     /gene="CCDC196"
                     /gene_synonym="C14orf53; LINC00238; NCRNA00238"
                     /coded_by="XM_024449605.2:133..855"
                     /db_xref="GeneID:440184"
                     /db_xref="HGNC:HGNC:20100"
ORIGIN      
        1 mtsganssgs ylpseirssk iddnylkeln edlklrkqel lemlkpledk nnllfqklms
       61 nleekqrslq imrqimagkg ceessvmell keaeemkqnl erknkmlrke memlwnktfe
      121 aeelsdqqka pqtknkadlq dgkapkspss prkteselek sfaekvkeir kekqqrkmew
      181 vkyqeqnnil qndfhgkvie lriealknyq kandlklsly lqqnfepmqa flnlpgsqaq
//
LOCUS       XP_024305374             226 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 196 isoform X4 [Homo
            sapiens].
ACCESSION   XP_024305374
VERSION     XP_024305374.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449606.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..226
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..226
                     /product="coiled-coil domain-containing protein 196
                     isoform X4"
                     /calculated_mol_wt=26096
     Region          <26..199
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     CDS             1..226
                     /gene="CCDC196"
                     /gene_synonym="C14orf53; LINC00238; NCRNA00238"
                     /coded_by="XM_024449606.2:133..813"
                     /db_xref="GeneID:440184"
                     /db_xref="HGNC:HGNC:20100"
ORIGIN      
        1 mtsganssgs ylpseirssk iddnylkeln edlklrkqel lemlkpledk nnllfqklms
       61 nleekqrslq imrqimagkg ceessvmell keaeemkqnl tfeaeelsdq qkapqtknka
      121 dlqdgkapks pssprktese leksfaekvk eirkekqqrk mewvkyqeqn nilqndfhgk
      181 vielriealk nyqkandlkl slylqqnfep mqaflnlpgs qgiriv
//
LOCUS       XP_024305375             224 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 196 isoform X5 [Homo
            sapiens].
ACCESSION   XP_024305375
VERSION     XP_024305375.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449607.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..224
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..224
                     /product="coiled-coil domain-containing protein 196
                     isoform X5"
                     /calculated_mol_wt=25873
     Region          <26..199
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     CDS             1..224
                     /gene="CCDC196"
                     /gene_synonym="C14orf53; LINC00238; NCRNA00238"
                     /coded_by="XM_024449607.2:133..807"
                     /db_xref="GeneID:440184"
                     /db_xref="HGNC:HGNC:20100"
ORIGIN      
        1 mtsganssgs ylpseirssk iddnylkeln edlklrkqel lemlkpledk nnllfqklms
       61 nleekqrslq imrqimagkg ceessvmell keaeemkqnl tfeaeelsdq qkapqtknka
      121 dlqdgkapks pssprktese leksfaekvk eirkekqqrk mewvkyqeqn nilqndfhgk
      181 vielriealk nyqkandlkl slylqqnfep mqaflnlpgs qafp
//
LOCUS       XP_024305376             213 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 196 isoform X6 [Homo
            sapiens].
ACCESSION   XP_024305376
VERSION     XP_024305376.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449608.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..213
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..213
                     /product="coiled-coil domain-containing protein 196
                     isoform X6"
                     /calculated_mol_wt=24950
     Region          24..>112
                     /region_name="PRK12704"
                     /note="phosphodiesterase; Provisional"
                     /db_xref="CDD:237177"
     CDS             1..213
                     /gene="CCDC196"
                     /gene_synonym="C14orf53; LINC00238; NCRNA00238"
                     /coded_by="XM_024449608.2:133..774"
                     /db_xref="GeneID:440184"
                     /db_xref="HGNC:HGNC:20100"
ORIGIN      
        1 mtsganssgs ylpseirssk iddnylkeln edlklrkqel lemlkpledk nnllfqklms
       61 nleekqrslq imrqimagkg ceessvmell keaeemkqnl erknkmlrke memlwnktfe
      121 aeelsdqqka pqtknkadlq dgkekqqrkm ewvkyqeqnn ilqndfhgkv ielriealkn
      181 yqkandlkls lylqqnfepm qaflnlpgsq afp
//
LOCUS       XP_024305377             196 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 196 isoform X7 [Homo
            sapiens].
ACCESSION   XP_024305377
VERSION     XP_024305377.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449609.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..196
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..196
                     /product="coiled-coil domain-containing protein 196
                     isoform X7"
                     /calculated_mol_wt=22703
     CDS             1..196
                     /gene="CCDC196"
                     /gene_synonym="C14orf53; LINC00238; NCRNA00238"
                     /coded_by="XM_024449609.2:133..723"
                     /db_xref="GeneID:440184"
                     /db_xref="HGNC:HGNC:20100"
ORIGIN      
        1 mtsganssgs ylpseirssk iddnylkeln edlklrkqel lemlkpledk nnllfqklms
       61 nleekqrslq imrqimagkg ceessvmell keaeemkqnl tfeaeelsdq qkapqtknka
      121 dlqdgkekqq rkmewvkyqe qnnilqndfh gkvielriea lknyqkandl klslylqqnf
      181 epmqaflnlp gsqafp
//
LOCUS       XP_047287371             193 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 196 isoform X8 [Homo
            sapiens].
ACCESSION   XP_047287371
VERSION     XP_047287371.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431415.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..193
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..193
                     /product="coiled-coil domain-containing protein 196
                     isoform X8"
                     /calculated_mol_wt=22040
     Region          24..>112
                     /region_name="PRK12704"
                     /note="phosphodiesterase; Provisional"
                     /db_xref="CDD:237177"
     CDS             1..193
                     /gene="CCDC196"
                     /gene_synonym="C14orf53; LINC00238; NCRNA00238"
                     /coded_by="XM_047431415.1:133..714"
                     /db_xref="GeneID:440184"
                     /db_xref="HGNC:HGNC:20100"
ORIGIN      
        1 mtsganssgs ylpseirssk iddnylkeln edlklrkqel lemlkpledk nnllfqklms
       61 nleekqrslq imrqimagkg ceessvmell keaeemkqnl erknkmlrke memlwnktfe
      121 aeelsdqqka pqtknkadlq dgkapkspss prkteselek sfaekvkeir krlflppgka
      181 teengmgqvs gtk
//
LOCUS       XP_024305380             172 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 196 isoform X9 [Homo
            sapiens].
ACCESSION   XP_024305380
VERSION     XP_024305380.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449612.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..172
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..172
                     /product="coiled-coil domain-containing protein 196
                     isoform X9"
                     /calculated_mol_wt=20103
     CDS             1..172
                     /gene="CCDC196"
                     /gene_synonym="C14orf53; LINC00238; NCRNA00238"
                     /coded_by="XM_024449612.1:99..617"
                     /db_xref="GeneID:440184"
                     /db_xref="HGNC:HGNC:20100"
ORIGIN      
        1 mrqimagkgc eessvmellk eaeemkqnle rknkmlrkem emlwnktfea eelsdqqkap
       61 qtknkadlqd gkapkspssp rkteseleks faekvkeirk ekqqrkmewv kyqeqnnilq
      121 ndfhgkviel riealknyqk andlklslyl qqnfepmqaf lnlpgsqgir iv
//
LOCUS       XP_024305381             169 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 196 isoform X10 [Homo
            sapiens].
ACCESSION   XP_024305381
VERSION     XP_024305381.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449613.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..169
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..169
                     /product="coiled-coil domain-containing protein 196
                     isoform X10"
                     /calculated_mol_wt=19668
     Region          24..>112
                     /region_name="PRK12704"
                     /note="phosphodiesterase; Provisional"
                     /db_xref="CDD:237177"
     CDS             1..169
                     /gene="CCDC196"
                     /gene_synonym="C14orf53; LINC00238; NCRNA00238"
                     /coded_by="XM_024449613.2:133..642"
                     /db_xref="GeneID:440184"
                     /db_xref="HGNC:HGNC:20100"
ORIGIN      
        1 mtsganssgs ylpseirssk iddnylkeln edlklrkqel lemlkpledk nnllfqklms
       61 nleekqrslq imrqimagkg ceessvmell keaeemkqnl erknkmlrke memlwnkndf
      121 hgkvielrie alknyqkand lklslylqqn fepmqaflnl pgsqgiriv
//
LOCUS       XP_024305382             167 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 196 isoform X11 [Homo
            sapiens].
ACCESSION   XP_024305382
VERSION     XP_024305382.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449614.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..167
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..167
                     /product="coiled-coil domain-containing protein 196
                     isoform X11"
                     /calculated_mol_wt=19445
     Region          24..>112
                     /region_name="PRK12704"
                     /note="phosphodiesterase; Provisional"
                     /db_xref="CDD:237177"
     CDS             1..167
                     /gene="CCDC196"
                     /gene_synonym="C14orf53; LINC00238; NCRNA00238"
                     /coded_by="XM_024449614.2:133..636"
                     /db_xref="GeneID:440184"
                     /db_xref="HGNC:HGNC:20100"
ORIGIN      
        1 mtsganssgs ylpseirssk iddnylkeln edlklrkqel lemlkpledk nnllfqklms
       61 nleekqrslq imrqimagkg ceessvmell keaeemkqnl erknkmlrke memlwnkndf
      121 hgkvielrie alknyqkand lklslylqqn fepmqaflnl pgsqafp
//
LOCUS       XP_047287372             152 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 196 isoform X12 [Homo
            sapiens].
ACCESSION   XP_047287372
VERSION     XP_047287372.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431416.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..152
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..152
                     /product="coiled-coil domain-containing protein 196
                     isoform X12"
                     /calculated_mol_wt=17421
     CDS             1..152
                     /gene="CCDC196"
                     /gene_synonym="C14orf53; LINC00238; NCRNA00238"
                     /coded_by="XM_047431416.1:133..591"
                     /db_xref="GeneID:440184"
                     /db_xref="HGNC:HGNC:20100"
ORIGIN      
        1 mtsganssgs ylpseirssk iddnylkeln edlklrkqel lemlkpledk nnllfqklms
       61 nleekqrslq imrqimagkg ceessvmell keaeemkqnl ndfhgkviel riealknyqk
      121 andlklslyl qqnfepmqaf lnlpgsqgir iv
//
LOCUS       XP_047287373             150 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 196 isoform X13 [Homo
            sapiens].
ACCESSION   XP_047287373
VERSION     XP_047287373.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431417.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..150
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..150
                     /product="coiled-coil domain-containing protein 196
                     isoform X13"
                     /calculated_mol_wt=17198
     CDS             1..150
                     /gene="CCDC196"
                     /gene_synonym="C14orf53; LINC00238; NCRNA00238"
                     /coded_by="XM_047431417.1:133..585"
                     /db_xref="GeneID:440184"
                     /db_xref="HGNC:HGNC:20100"
ORIGIN      
        1 mtsganssgs ylpseirssk iddnylkeln edlklrkqel lemlkpledk nnllfqklms
       61 nleekqrslq imrqimagkg ceessvmell keaeemkqnl ndfhgkviel riealknyqk
      121 andlklslyl qqnfepmqaf lnlpgsqafp
//
LOCUS       XP_024305383             148 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 196 isoform X14 [Homo
            sapiens].
ACCESSION   XP_024305383
VERSION     XP_024305383.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449615.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..148
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..148
                     /product="coiled-coil domain-containing protein 196
                     isoform X14"
                     /calculated_mol_wt=17173
     Region          24..>112
                     /region_name="PRK12704"
                     /note="phosphodiesterase; Provisional"
                     /db_xref="CDD:237177"
     CDS             1..148
                     /gene="CCDC196"
                     /gene_synonym="C14orf53; LINC00238; NCRNA00238"
                     /coded_by="XM_024449615.2:133..579"
                     /db_xref="GeneID:440184"
                     /db_xref="HGNC:HGNC:20100"
ORIGIN      
        1 mtsganssgs ylpseirssk iddnylkeln edlklrkqel lemlkpledk nnllfqklms
       61 nleekqrslq imrqimagkg ceessvmell keaeemkqnl erknkmlrke memlwnktfe
      121 aeelsdqqka pqtknkadlq dgkdllfl
//
LOCUS       XP_024305385             139 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 196 isoform X15 [Homo
            sapiens].
ACCESSION   XP_024305385
VERSION     XP_024305385.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449617.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..139
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..139
                     /product="coiled-coil domain-containing protein 196
                     isoform X15"
                     /calculated_mol_wt=15969
     Region          24..>112
                     /region_name="PRK12704"
                     /note="phosphodiesterase; Provisional"
                     /db_xref="CDD:237177"
     CDS             1..139
                     /gene="CCDC196"
                     /gene_synonym="C14orf53; LINC00238; NCRNA00238"
                     /coded_by="XM_024449617.2:133..552"
                     /db_xref="GeneID:440184"
                     /db_xref="HGNC:HGNC:20100"
ORIGIN      
        1 mtsganssgs ylpseirssk iddnylkeln edlklrkqel lemlkpledk nnllfqklms
       61 nleekqrslq imrqimagkg ceessvmell keaeemkqnl erknkmlrke memlwnkrlf
      121 lppgkateen gmgqvsgtk
//
LOCUS       XP_011535098            1992 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Daple isoform X1 [Homo sapiens].
ACCESSION   XP_011535098
VERSION     XP_011535098.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536796.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1992
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1992
                     /product="protein Daple isoform X1"
                     /calculated_mol_wt=224161
     Region          1..128
                     /region_name="HkD_SF"
                     /note="Hook domain-containing proteins superfamily;
                     cl41774"
                     /db_xref="CDD:425405"
     Site            order(96,113,116..117,119..120,123..124,127)
                     /site_type="other"
                     /note="LIC-binding interface [polypeptide binding]"
                     /db_xref="CDD:411792"
     Region          <185..663
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          468..1282
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          1570..>1984
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     CDS             1..1992
                     /gene="CCDC88C"
                     /gene_synonym="DAPLE; HKRP2; HYC1; KIAA1509; SCA40"
                     /coded_by="XM_011536796.3:273..6251"
                     /db_xref="GeneID:440193"
                     /db_xref="HGNC:HGNC:19967"
                     /db_xref="MIM:611204"
ORIGIN      
        1 mymdlvdgif lnqimlqidp rptnqrinkh vnndvnlriq nltilvrnik tyyqevlqql
       61 ivmnlpnvlm igrdplsgks meeikkvlll vlgcavqcer keefierikq ldietqagiv
      121 ahiqevthnq envfdlqwle lpdvapeele alsrsmvlhl rrlidqrdec telivdltqe
      181 rdylqaqhpp spiksssads tpsptsslss edkqhlavel adtkarlrrv rqeledkteq
      241 lvdtrhevdq lvlelqkvkq eniqlaadar sarayrdeld slrekanrve rleleltrck
      301 eklhdvdfyk armeelredn iilietkaml eeqltaarar gdkvheleke nlqlksklhd
      361 leldrdtdkk rieelleenm vleiaqkqsm nesahlgwel eqlsknadls dasrksfvfe
      421 lnecassril klekenqslq stiqglrdas lvleesglkc gelekenhql skkieklqtq
      481 lerekqsnqd letlseelir ekeqlqsdme tlkadkarqi kdleqekdhl nramwslrer
      541 sqvssearmk dvekenkalh qtvteangkl sqlefekrql hrdleqakek geraeklere
      601 lqrlqeengr larkvtslet atekvealeh esqglqlenr tlrksldtlq nvslqlegle
      661 rdnkqldaen lelrrlvetm rftstklaqm erenqqlere keelrknvdl lkalgkkser
      721 lelsyqsvsa enlrlqqsle ssshktqtle selgeleaer qalrrdleal rlanaqlega
      781 ekdrkaleqe vaqlekdkkl lekeakrlwq qvelkdavld dstaklsave kesraldkel
      841 arcrdaagkl kelekdnrdl tkqvtvhart lttlredlvl eklksqqlss eldklsqele
      901 kvglnrelll qeddsgsdtk ykilegrnes alkttlamke ekivlleaqm eekaslnrql
      961 eselqmlkke cetlrqnqge gqhlqnsfkh pagktaashq gkeawgpghk eatmellrvk
     1021 draielernn aalqaekqll keqlqhletq nvtfssqilt lqkqsaflqe hnttlqtqta
     1081 klqvenstls sqsaaltaqy tllqnhhtak eteneslqrq qeqltaayea llqdhehlgt
     1141 lherqsaeye alirqhsclk tlhrnleleh kelgerhgdm lkrkaeleer ekvltterea
     1201 lqqeqrtnal amgenqrlrg eldrvnflhh qlkgeyeelh ahtkelktsl nnaqlelnrw
     1261 qarfdelkeq hqtmdisltk ldnhcellsr lkgnleeenh hllsqiqlls qqnqmlleqn
     1321 menkeqyhee qkqyidklna lrrhkeklee kimdqykfyd pppkkknhwi gakalvklik
     1381 pkkegsrerl kstvdsppwq lessdpaspa asqplrsqae npdtpalgsn caeerdahng
     1441 svgkgpgdlk pkrgsphrgs ldrtdastdl amrswpselg srtcstsatt tapsnstpia
     1501 rhpgrtkgyn sddnlcepsl efevpnhrqy vsrpssless rntssnsspl nlkgsseqlh
     1561 grsesfssed lipsrdlatl preastpgrn algrheyplp rngplpqega qkrgtappyv
     1621 gvrpcsasps semvtleefl eesnrsspth dtpscrddll sdyfrkasdp paiggqpgpp
     1681 akkegakmpt nfvaptvkma aptsegrplk pgqyvkpnfr lteaeappsv aprqaqppqs
     1741 lslgrprqap vppashapas rsaslsrafs lasadllras gpeackqesp qklgapealg
     1801 gretgshtlq spappsshsl arertplvgk agsscqgpgp rsrpldtrrf slappkeerl
     1861 aplhqsatap aiatagagaa aagsgsnsql lhfspaaapa artkpkappr sgevatitpv
     1921 raglslsegd gvpgqgcseg lpakspgrsp dlaphlgral edcsrgsvsk sspaspepgg
     1981 dpqtvwyeyg cv
//
LOCUS       XP_047287374            1939 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Daple isoform X2 [Homo sapiens].
ACCESSION   XP_047287374
VERSION     XP_047287374.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431418.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1939
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1939
                     /product="protein Daple isoform X2"
                     /calculated_mol_wt=217944
     Region          <25..75
                     /region_name="HkD_SF"
                     /note="Hook domain-containing proteins superfamily;
                     cl41774"
                     /db_xref="CDD:425405"
     Site            order(43,60,63..64,66..67,70..71,74)
                     /site_type="other"
                     /note="LIC-binding interface [polypeptide binding]"
                     /db_xref="CDD:411792"
     Region          <132..610
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          415..1229
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          1517..>1931
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     CDS             1..1939
                     /gene="CCDC88C"
                     /gene_synonym="DAPLE; HKRP2; HYC1; KIAA1509; SCA40"
                     /coded_by="XM_047431418.1:36..5855"
                     /db_xref="GeneID:440193"
                     /db_xref="HGNC:HGNC:19967"
                     /db_xref="MIM:611204"
ORIGIN      
        1 masssptlcg hrrlrrreem lfvkgksmee ikkvlllvlg cavqcerkee fierikqldi
       61 etqagivahi qevthnqenv fdlqwlelpd vapeeleals rsmvlhlrrl idqrdectel
      121 ivdltqerdy lqaqhppspi ksssadstps ptsslssedk qhlaveladt karlrrvrqe
      181 ledkteqlvd trhevdqlvl elqkvkqeni qlaadarsar ayrdeldslr ekanrverle
      241 leltrckekl hdvdfykarm eelredniil ietkamleeq ltaarargdk vhelekenlq
      301 lksklhdlel drdtdkkrie elleenmvle iaqkqsmnes ahlgweleql sknadlsdas
      361 rksfvfelne cassrilkle kenqslqsti qglrdaslvl eesglkcgel ekenhqlskk
      421 ieklqtqler ekqsnqdlet lseelireke qlqsdmetlk adkarqikdl eqekdhlnra
      481 mwslrersqv ssearmkdve kenkalhqtv teangklsql efekrqlhrd leqakekger
      541 aeklerelqr lqeengrlar kvtsletate kvealehesq glqlenrtlr ksldtlqnvs
      601 lqleglerdn kqldaenlel rrlvetmrft stklaqmere nqqlerekee lrknvdllka
      661 lgkkserlel syqsvsaenl rlqqslesss hktqtlesel geleaerqal rrdlealrla
      721 naqlegaekd rkaleqevaq lekdkkllek eakrlwqqve lkdavlddst aklsavekes
      781 raldkelarc rdaagklkel ekdnrdltkq vtvhartltt lredlvlekl ksqqlsseld
      841 klsqelekvg lnrelllqed dsgsdtkyki legrnesalk ttlamkeeki vlleaqmeek
      901 aslnrqlese lqmlkkecet lrqnqgegqh lqnsfkhpag ktaashqgke awgpghkeat
      961 mellrvkdra ielernnaal qaekqllkeq lqhletqnvt fssqiltlqk qsaflqehnt
     1021 tlqtqtaklq venstlssqs aaltaqytll qnhhtakete neslqrqqeq ltaayeallq
     1081 dhehlgtlhe rqsaeyeali rqhsclktlh rnlelehkel gerhgdmlkr kaeleerekv
     1141 ltterealqq eqrtnalamg enqrlrgeld rvnflhhqlk geyeelhaht kelktslnna
     1201 qlelnrwqar fdelkeqhqt mdisltkldn hcellsrlkg nleeenhhll sqiqllsqqn
     1261 qmlleqnmen keqyheeqkq yidklnalrr hkekleekim dqykfydppp kkknhwigak
     1321 alvklikpkk egsrerlkst vdsppwqles sdpaspaasq plrsqaenpd tpalgsncae
     1381 erdahngsvg kgpgdlkpkr gsphrgsldr tdastdlamr swpselgsrt cstsatttap
     1441 snstpiarhp grtkgynsdd nlcepslefe vpnhrqyvsr psslessrnt ssnssplnlk
     1501 gsseqlhgrs esfssedlip srdlatlpre astpgrnalg rheyplprng plpqegaqkr
     1561 gtappyvgvr pcsaspssem vtleeflees nrsspthdtp scrddllsdy frkasdppai
     1621 ggqpgppakk egakmptnfv aptvkmaapt segrplkpgq yvkpnfrlte aeappsvapr
     1681 qaqppqslsl grprqapvpp ashapasrsa slsrafslas adllrasgpe ackqespqkl
     1741 gapealggre tgshtlqspa ppsshslare rtplvgkags scqgpgprsr pldtrrfsla
     1801 ppkeerlapl hqsatapaia tagagaaaag sgsnsqllhf spaaapaart kpkapprsge
     1861 vatitpvrag lslsegdgvp gqgcseglpa kspgrspdla phlgraledc srgsvskssp
     1921 aspepggdpq tvwyeygcv
//
LOCUS       XP_024305386             369 aa            linear   PRI 05-AUG-2025
DEFINITION  olfactory receptor 4Q3 isoform X1, partial [Homo sapiens].
ACCESSION   XP_024305386
VERSION     XP_024305386.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449618.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 15% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: incomplete on the carboxy end.
FEATURES             Location/Qualifiers
     source          1..369
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..>369
                     /product="olfactory receptor 4Q3 isoform X1"
     Region          98..355
                     /region_name="7tmA_OR4Q3-like"
                     /note="olfactory receptor 4Q3 and related proteins, member
                     of the class A family of seven-transmembrane G
                     protein-coupled receptors; cd15935"
                     /db_xref="CDD:320601"
     Region          123..149
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320601"
     Site            order(145,148..149,161..166,168..169,172,217,219..223,259,
                     262..264,266..268,270..271,315,318..319,321..322,325,
                     329..330,332..334,337,340..341)
                     /site_type="other"
                     /note="putative ligand binding pocket [chemical binding]"
                     /db_xref="CDD:320601"
     Region          161..191
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320601"
     Region          204..225
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320601"
     Region          259..289
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320601"
     Region          295..325
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320601"
     Region          330..355
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320601"
     CDS             1..369
                     /gene="OR4Q3"
                     /gene_synonym="C14orf13; c14_5008; HSA6; OR14-3; OR4Q4"
                     /coded_by="XM_024449618.1:1..>1107"
                     /db_xref="GeneID:441669"
                     /db_xref="HGNC:HGNC:15426"
ORIGIN      
        1 mklvflnvaf qalqgfgkgn yvvtgvlssn vgdeyecrag engsnnilan llyflmsldi
       61 lglmkkeqds nvtefvllgl ssswelqlfl fllflffyia ivlgnllivv tvqahahllq
      121 spmyyflghl sfidlclscv tvpkmlgdfl qqgksisfsg claqiyflhf lgasemfllt
      181 vmaydryvai cnplryltvm npqlclwlvl acwcggfihs imqvilviql pfcgpneldn
      241 fycdvpqvik lacmdtyvve vlviansgll slvcflvllf syaiilitlr thfcqgqnkv
      301 fstcashltv vslifvpcvf iylrpfcsfs vdkifslfyt vitpmlnpli ytlrntdmkt
      361 amkklrkkq
//
LOCUS       XP_047287377              58 aa            linear   PRI 05-AUG-2025
DEFINITION  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 isoform
            X1 [Homo sapiens].
ACCESSION   XP_047287377
VERSION     XP_047287377.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431421.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..58
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..58
                     /product="NADH dehydrogenase [ubiquinone] 1 beta
                     subcomplex subunit 1 isoform X1"
                     /calculated_mol_wt=6830
     Region          3..58
                     /region_name="NADH_oxidored"
                     /note="MNLL subunit; pfam08040"
                     /db_xref="CDD:462345"
     CDS             1..58
                     /gene="NDUFB1"
                     /gene_synonym="CI-MNLL; CI-SGDH; MNLL"
                     /coded_by="XM_047431421.1:275..451"
                     /db_xref="GeneID:4707"
                     /db_xref="HGNC:HGNC:7695"
                     /db_xref="MIM:603837"
ORIGIN      
        1 mvnllqivrd hwvhvlvpmg fvigcyldrk sderltafrn ksmlfkrelq pseevtwk
//
LOCUS       XP_016876834             385 aa            linear   PRI 05-AUG-2025
DEFINITION  RNA-binding protein Nova-1 isoform X1 [Homo sapiens].
ACCESSION   XP_016876834
VERSION     XP_016876834.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021345.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..385
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..385
                     /product="RNA-binding protein Nova-1 isoform X1"
                     /calculated_mol_wt=38580
     Region          50..119
                     /region_name="KH-I_NOVA_rpt2"
                     /note="second type I K homology (KH) RNA-binding domain
                     found in the family of neuro-oncological ventral antigen
                     (Nova); cd22436"
                     /db_xref="CDD:411864"
     Site            order(61..63,65..69,72..73,83..85,87..89,97)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:411864"
     Region          300..370
                     /region_name="KH-I_NOVA_rpt3"
                     /note="third type I K homology (KH) RNA-binding domain
                     found in the family of neuro-oncological ventral antigen
                     (Nova); cd09031"
                     /db_xref="CDD:411807"
     Site            order(308..309,311..313,315..319,322..323,333..339,341,
                     346,348)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:411807"
     CDS             1..385
                     /gene="NOVA1"
                     /gene_synonym="Nova-1"
                     /coded_by="XM_017021345.2:431..1588"
                     /db_xref="GeneID:4857"
                     /db_xref="HGNC:HGNC:7886"
                     /db_xref="MIM:602157"
ORIGIN      
        1 mpqnvaktep vsilqpqttv npdrikqtlp ssptttkssp sdpmttsran qvkiivpnst
       61 agliigkgga tvkavmeqsg awvqlsqkpd ginlqervvt vsgepeqnrk aveliiqkiq
      121 edpqsgscln isyanvtgpv ansnptgspy antaevlpta aaaagllgha nlagvaafpa
      181 vlsgftgndl vaitsalntl asygynlntl glglsqaaat galaaaaasa npaaaaanll
      241 atyaseasas gstaggtagt falgslaaat aatngyfgaa splaasailg tekstdgskd
      301 vveiavpenl vgailgkggk tlveyqeltg ariqiskkge fvpgtrnrkv titgtpaatq
      361 aaqylitqri tyeqgvraan pqkvg
//
LOCUS       XP_011535103             339 aa            linear   PRI 05-AUG-2025
DEFINITION  neural retina-specific leucine zipper protein isoform X1 [Homo
            sapiens].
ACCESSION   XP_011535103
VERSION     XP_011535103.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536801.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Jun 6, 2016 this sequence version replaced XP_011535103.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..339
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..339
                     /product="neural retina-specific leucine zipper protein
                     isoform X1"
                     /calculated_mol_wt=37084
     Region          169..203
                     /region_name="Maf_N"
                     /note="Maf N-terminal region; pfam08383"
                     /db_xref="CDD:462456"
     Region          256..325
                     /region_name="bZIP_Maf_large"
                     /note="Basic leucine zipper (bZIP) domain of large
                     musculoaponeurotic fibrosarcoma (Maf) proteins: a
                     DNA-binding and dimerization domain; cd14718"
                     /db_xref="CDD:269866"
     Region          256..325
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:269866"
     Site            order(263,266..268,270..272,274..276,278..279,281..282)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:269866"
     Site            order(282,289,292..293,296..297,299..300,303..304,
                     306..307,310,313..314,317..318,320..321)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:269866"
     CDS             1..339
                     /gene="NRL"
                     /gene_synonym="D14S46E; NRL-MAF; RP27"
                     /coded_by="XM_011536801.3:25..1044"
                     /db_xref="GeneID:4901"
                     /db_xref="HGNC:HGNC:8002"
                     /db_xref="MIM:162080"
ORIGIN      
        1 mrrpgsaers eereevlrva drdravrger gregevqaet rstgrlpsqe trgaggwths
       61 srpcpppprm gnlaeaesrr aplaaprgra qrkvhssqps srmalppspl ameyvndfdl
      121 mkfevkreps egrpgpptas lgstpyssvp psptfsepgm vgategtrpg leelywlatl
      181 qqqlgageal glspeeamel lqgqgpvpvd gphgyypgsp eetgaqhvql aerfsdaalv
      241 smsvrelnrq lrgcgrdeal rlkqrrrtlk nrgyaqacrs krlqqrrgle aerarlaaql
      301 dalraevarl arerdlykar cdrltssgpg sgdpshlfl
//
LOCUS       XP_011535107             237 aa            linear   PRI 05-AUG-2025
DEFINITION  neural retina-specific leucine zipper protein isoform X2 [Homo
            sapiens].
ACCESSION   XP_011535107
VERSION     XP_011535107.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536805.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..237
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..237
                     /product="neural retina-specific leucine zipper protein
                     isoform X2"
                     /calculated_mol_wt=25809
     Region          67..101
                     /region_name="Maf_N"
                     /note="Maf N-terminal region; pfam08383"
                     /db_xref="CDD:462456"
     Region          154..223
                     /region_name="bZIP_Maf_large"
                     /note="Basic leucine zipper (bZIP) domain of large
                     musculoaponeurotic fibrosarcoma (Maf) proteins: a
                     DNA-binding and dimerization domain; cd14718"
                     /db_xref="CDD:269866"
     Region          154..223
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:269866"
     Site            order(161,164..166,168..170,172..174,176..177,179..180)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:269866"
     Site            order(180,187,190..191,194..195,197..198,201..202,
                     204..205,208,211..212,215..216,218..219)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:269866"
     CDS             1..237
                     /gene="NRL"
                     /gene_synonym="D14S46E; NRL-MAF; RP27"
                     /coded_by="XM_011536805.3:168..881"
                     /db_xref="GeneID:4901"
                     /db_xref="HGNC:HGNC:8002"
                     /db_xref="MIM:162080"
ORIGIN      
        1 malppsplam eyvndfdlmk fevkrepseg rpgpptaslg stpyssvpps ptfsepgmvg
       61 ategtrpgle elywlatlqq qlgagealgl speeamellq gqgpvpvdgp hgyypgspee
      121 tgaqhvqlae rfsdaalvsm svrelnrqlr gcgrdealrl kqrrrtlknr gyaqacrskr
      181 lqqrrgleae rarlaaqlda lraevarlar erdlykarcd rltssgpgsg dpshlfl
//
LOCUS       XP_011535108             234 aa            linear   PRI 05-AUG-2025
DEFINITION  neural retina-specific leucine zipper protein isoform X3 [Homo
            sapiens].
ACCESSION   XP_011535108
VERSION     XP_011535108.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536806.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Jun 6, 2016 this sequence version replaced XP_011535108.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..234
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..234
                     /product="neural retina-specific leucine zipper protein
                     isoform X3"
                     /calculated_mol_wt=26221
     Region          151..220
                     /region_name="bZIP_Maf_large"
                     /note="Basic leucine zipper (bZIP) domain of large
                     musculoaponeurotic fibrosarcoma (Maf) proteins: a
                     DNA-binding and dimerization domain; cd14718"
                     /db_xref="CDD:269866"
     Region          151..220
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:269866"
     Site            order(158,161..163,165..167,169..171,173..174,176..177)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:269866"
     Site            order(177,184,187..188,191..192,194..195,198..199,
                     201..202,205,208..209,212..213,215..216)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:269866"
     CDS             1..234
                     /gene="NRL"
                     /gene_synonym="D14S46E; NRL-MAF; RP27"
                     /coded_by="XM_011536806.3:25..729"
                     /db_xref="GeneID:4901"
                     /db_xref="HGNC:HGNC:8002"
                     /db_xref="MIM:162080"
ORIGIN      
        1 mrrpgsaers eereevlrva drdravrger gregevqaet rstgrlpsqe trgaggwths
       61 srpcpppprm gnlaeaesrr aplaaprgra qrkvhssqps srmalppspl ameyvndfdl
      121 mkfelaerfs daalvsmsvr elnrqlrgcg rdealrlkqr rrtlknrgya qacrskrlqq
      181 rrgleaerar laaqldalra evarlarerd lykarcdrlt ssgpgsgdps hlfl
//
LOCUS       XP_005267778             208 aa            linear   PRI 05-AUG-2025
DEFINITION  ER membrane protein complex subunit 9 isoform X1 [Homo sapiens].
ACCESSION   XP_005267778
VERSION     XP_005267778.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267721.6
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..208
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..208
                     /product="ER membrane protein complex subunit 9 isoform
                     X1"
                     /calculated_mol_wt=22930
     Region          4..191
                     /region_name="UPF0172"
                     /note="Uncharacterized protein family (UPF0172);
                     pfam03665"
                     /db_xref="CDD:461011"
     CDS             1..208
                     /gene="EMC9"
                     /gene_synonym="C14orf122; CGI-112; FAM158A"
                     /coded_by="XM_005267721.6:288..914"
                     /db_xref="GeneID:51016"
                     /db_xref="HGNC:HGNC:20273"
ORIGIN      
        1 mgeveisala yvkmclhaar yphaavnglf lapaprsgec lcltdcvplf hshlalsvml
       61 evalnqvdvw gaqaglvvag yyhanaavnd qspgplalki agriaeffpd avlimldnqk
      121 lvpqprvppv ivlenqglrw vpkdknlvmw rdweesrqmv galledrahq hlvdfdchld
      181 dirqdwtnqr lntqitqwvg ptngngna
//
LOCUS       XP_047287382             134 aa            linear   PRI 05-AUG-2025
DEFINITION  ER membrane protein complex subunit 9 isoform X2 [Homo sapiens].
ACCESSION   XP_047287382
VERSION     XP_047287382.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431426.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..134
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..134
                     /product="ER membrane protein complex subunit 9 isoform
                     X2"
                     /calculated_mol_wt=15246
     Region          <18..114
                     /region_name="MPN"
                     /note="Mpr1p, Pad1p N-terminal (MPN) domains; cl13996"
                     /db_xref="CDD:472685"
     CDS             1..134
                     /gene="EMC9"
                     /gene_synonym="C14orf122; CGI-112; FAM158A"
                     /coded_by="XM_047431426.1:1543..1947"
                     /db_xref="GeneID:51016"
                     /db_xref="HGNC:HGNC:20273"
ORIGIN      
        1 mgfahswllt plifplhspg plalkiagri aeffpdavli mldnqklvpq prvppvivle
       61 nqglrwvpkd knlvmwrdwe esrqmvgall edrahqhlvd fdchlddirq dwtnqrlntq
      121 itqwvgptng ngna
//
LOCUS       XP_047287383             123 aa            linear   PRI 05-AUG-2025
DEFINITION  ER membrane protein complex subunit 9 isoform X3 [Homo sapiens].
ACCESSION   XP_047287383
VERSION     XP_047287383.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431427.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..123
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..123
                     /product="ER membrane protein complex subunit 9 isoform
                     X3"
                     /calculated_mol_wt=13112
     Region          4..>92
                     /region_name="UPF0172"
                     /note="Uncharacterized protein family (UPF0172);
                     pfam03665"
                     /db_xref="CDD:461011"
     CDS             1..123
                     /gene="EMC9"
                     /gene_synonym="C14orf122; CGI-112; FAM158A"
                     /coded_by="XM_047431427.1:288..659"
                     /db_xref="GeneID:51016"
                     /db_xref="HGNC:HGNC:20273"
ORIGIN      
        1 mgeveisala yvkmclhaar yphaavnglf lapaprsgec lcltdcvplf hshlalsvml
       61 evalnqvdvw gaqaglvvag yyhanaavnd qstqasssra ssiqqarspq atyrerpqlr
      121 phl
//
LOCUS       XP_047287384             506 aa            linear   PRI 05-AUG-2025
DEFINITION  phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1
            [Homo sapiens].
ACCESSION   XP_047287384
VERSION     XP_047287384.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431428.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..506
                     /product="phosphoenolpyruvate carboxykinase [GTP],
                     mitochondrial isoform X1"
                     /calculated_mol_wt=55822
     Region          1..499
                     /region_name="PEPCK_GTP"
                     /note="Phosphoenolpyruvate carboxykinase (PEPCK), a
                     critical gluconeogenic enzyme, catalyzes the first
                     committed step in the diversion of tricarboxylic acid
                     cycle intermediates toward gluconeogenesis. It catalyzes
                     the reversible decarboxylation and...; cd00819"
                     /db_xref="CDD:238417"
     Site            order(119,121,127..128,148,170..176,194..195,217,219,228,
                     289,411,414,417)
                     /site_type="active"
                     /db_xref="CDD:238417"
     Site            order(119,121,127..128,217,289)
                     /site_type="other"
                     /note="substrate-binding site [chemical binding]"
                     /db_xref="CDD:238417"
     Site            order(128,148,175,194..195,217)
                     /site_type="metal-binding"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238417"
     Site            order(171,173,320,400..401,411,414,417)
                     /site_type="other"
                     /note="GTP binding site [chemical binding]"
                     /db_xref="CDD:238417"
     CDS             1..506
                     /gene="PCK2"
                     /gene_synonym="mtPCK2; PEPCK; PEPCK-M; PEPCK2"
                     /coded_by="XM_047431428.1:458..1978"
                     /db_xref="GeneID:5106"
                     /db_xref="HGNC:HGNC:8725"
                     /db_xref="MIM:614095"
ORIGIN      
        1 mspadfqrav derfpgcmqg rtmyvlpfsm gpvgsplsri gvqltdsayv vasmrimtrl
       61 gtpvlqalgd gdfvkclhsv gqpltgqgep vsqwpcnpek tlighvpdqr eiisfgsgyg
      121 gnsllgkkcf alriasrlar degwlaehml ilgitspagk kryvaaafps acgktnlamm
      181 rpalpgwkve cvgddiawmr fdsegrlrai npengffgva pgtsattnpn amatiqsnti
      241 ftnvaetsdg gvywegidqp lppgvtvtsw lgkpwkpgdk epcahpnsrf caparqcpim
      301 dpaweapegv pidaiifggr rpkgvplvye afnwrhgvfv gsamrsesta aaehkgkiim
      361 hdpfamrpff gynfghyleh wlsmegrkga qlprifhvnw frrdeaghfl wpgfgenarv
      421 ldwicrrleg edsaretpig lvpkegaldl sglraidttq lfslpkdfwe qevrdirsyl
      481 teqvnqdlpk evlaeleale rrvhkm
//
LOCUS       XP_047287385             506 aa            linear   PRI 05-AUG-2025
DEFINITION  phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1
            [Homo sapiens].
ACCESSION   XP_047287385
VERSION     XP_047287385.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431429.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..506
                     /product="phosphoenolpyruvate carboxykinase [GTP],
                     mitochondrial isoform X1"
                     /calculated_mol_wt=55822
     Region          1..499
                     /region_name="PEPCK_GTP"
                     /note="Phosphoenolpyruvate carboxykinase (PEPCK), a
                     critical gluconeogenic enzyme, catalyzes the first
                     committed step in the diversion of tricarboxylic acid
                     cycle intermediates toward gluconeogenesis. It catalyzes
                     the reversible decarboxylation and...; cd00819"
                     /db_xref="CDD:238417"
     Site            order(119,121,127..128,148,170..176,194..195,217,219,228,
                     289,411,414,417)
                     /site_type="active"
                     /db_xref="CDD:238417"
     Site            order(119,121,127..128,217,289)
                     /site_type="other"
                     /note="substrate-binding site [chemical binding]"
                     /db_xref="CDD:238417"
     Site            order(128,148,175,194..195,217)
                     /site_type="metal-binding"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238417"
     Site            order(171,173,320,400..401,411,414,417)
                     /site_type="other"
                     /note="GTP binding site [chemical binding]"
                     /db_xref="CDD:238417"
     CDS             1..506
                     /gene="PCK2"
                     /gene_synonym="mtPCK2; PEPCK; PEPCK-M; PEPCK2"
                     /coded_by="XM_047431429.1:538..2058"
                     /db_xref="GeneID:5106"
                     /db_xref="HGNC:HGNC:8725"
                     /db_xref="MIM:614095"
ORIGIN      
        1 mspadfqrav derfpgcmqg rtmyvlpfsm gpvgsplsri gvqltdsayv vasmrimtrl
       61 gtpvlqalgd gdfvkclhsv gqpltgqgep vsqwpcnpek tlighvpdqr eiisfgsgyg
      121 gnsllgkkcf alriasrlar degwlaehml ilgitspagk kryvaaafps acgktnlamm
      181 rpalpgwkve cvgddiawmr fdsegrlrai npengffgva pgtsattnpn amatiqsnti
      241 ftnvaetsdg gvywegidqp lppgvtvtsw lgkpwkpgdk epcahpnsrf caparqcpim
      301 dpaweapegv pidaiifggr rpkgvplvye afnwrhgvfv gsamrsesta aaehkgkiim
      361 hdpfamrpff gynfghyleh wlsmegrkga qlprifhvnw frrdeaghfl wpgfgenarv
      421 ldwicrrleg edsaretpig lvpkegaldl sglraidttq lfslpkdfwe qevrdirsyl
      481 teqvnqdlpk evlaeleale rrvhkm
//
LOCUS       XP_006720221             497 aa            linear   PRI 05-AUG-2025
DEFINITION  phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X2
            [Homo sapiens].
ACCESSION   XP_006720221
VERSION     XP_006720221.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720158.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..497
                     /product="phosphoenolpyruvate carboxykinase [GTP],
                     mitochondrial isoform X2"
                     /calculated_mol_wt=53492
     Region          44..>490
                     /region_name="PEPCK_GTP"
                     /note="Phosphoenolpyruvate carboxykinase (PEPCK), a
                     critical gluconeogenic enzyme, catalyzes the first
                     committed step in the diversion of tricarboxylic acid
                     cycle intermediates toward gluconeogenesis. It catalyzes
                     the reversible decarboxylation and...; cd00819"
                     /db_xref="CDD:238417"
     Site            order(104,253,255,261..262,282,304..310,328..329,351,353,
                     362,423)
                     /site_type="active"
                     /db_xref="CDD:238417"
     Site            order(104,253,255,261..262,351,423)
                     /site_type="other"
                     /note="substrate-binding site [chemical binding]"
                     /db_xref="CDD:238417"
     Site            order(262,282,309,328..329,351)
                     /site_type="metal-binding"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238417"
     CDS             1..497
                     /gene="PCK2"
                     /gene_synonym="mtPCK2; PEPCK; PEPCK-M; PEPCK2"
                     /coded_by="XM_006720158.3:96..1589"
                     /db_xref="GeneID:5106"
                     /db_xref="HGNC:HGNC:8725"
                     /db_xref="MIM:614095"
ORIGIN      
        1 maalyrpglr lnwhglsplg wpscrsiqtl rvlsgdlgql ptgirdfveh sarlcqpegi
       61 hicdgteaen tatltlleqq glirklpkyn ncwlartdpk dvarvesktv ivtpsqrdtv
      121 plppggargq lgnwmspadf qravderfpg cmqgrtmyvl pfsmgpvgsp lsrigvqltd
      181 sayvvasmri mtrlgtpvlq algdgdfvkc lhsvgqpltg qgepvsqwpc npektlighv
      241 pdqreiisfg sgyggnsllg kkcfalrias rlardegwla ehmlilgits pagkkryvaa
      301 afpsacgktn lammrpalpg wkvecvgddi awmrfdsegr lrainpengf fgvapgtsat
      361 tnpnamatiq sntiftnvae tsdggvyweg idqplppgvt vtswlgkpwk pgdkepcahp
      421 nsrfcaparq cpimdpawea pegvpidaii fggrrpkgvp lvyeafnwrh gvfvgsamrs
      481 estaaaehkg llgtggs
//
LOCUS       XP_047287386             558 aa            linear   PRI 05-AUG-2025
DEFINITION  atlastin-1 isoform X1 [Homo sapiens].
ACCESSION   XP_047287386
VERSION     XP_047287386.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431430.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..558
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..558
                     /product="atlastin-1 isoform X1"
                     /calculated_mol_wt=63413
     Region          43..314
                     /region_name="GBP"
                     /note="Guanylate-binding protein, N-terminal domain;
                     pfam02263"
                     /db_xref="CDD:460516"
     CDS             1..558
                     /gene="ATL1"
                     /gene_synonym="AD-FSP; ATL-1; atlastin1; FSP1; GBP3;
                     HSN1D; SPG3; SPG3A"
                     /coded_by="XM_047431430.1:426..2102"
                     /db_xref="GeneID:51062"
                     /db_xref="HGNC:HGNC:11231"
                     /db_xref="MIM:606439"
ORIGIN      
        1 maknrrdrns wggfsektye wsseeeepvk kagpvqvliv kddhsfelde talnrillse
       61 avrdkevvav svagafrkgk sflmdfmlry mynqesvdwv gdynepltgf swrggseret
      121 tgiqiwseif linkpdgkkv avllmdtqgt fdsqstlrds atvfalstmi ssiqvynlsq
      181 nvqeddlqhl qlfteygrla meetflkpfq sliflvrdws fpyefsygad ggakflekrl
      241 kvsgnqheel qnvrkhihsc ftniscfllp hpglkvatnp nfdgklkeid defiknlkil
      301 ipwllspesl dikeingnki tcrglveyfk ayikiyqgee lphpksmlqa taeannlaav
      361 atakdtynkk meeicggdkp flapndlqtk hlqlkeesvk lfrgvkkmgg eefsrrylqq
      421 leseidelyi qyikhndskn ifhaartpat lfvvifityv iagvtgfigl diiaslcnmi
      481 mgltlitlct wayirysgey relgavidqv aaalwdqgst nealyklysa aathrhlyhq
      541 afptpksest eqsekkkm
//
LOCUS       XP_011535117             174 aa            linear   PRI 05-AUG-2025
DEFINITION  rRNA-processing protein FCF1 homolog isoform X1 [Homo sapiens].
ACCESSION   XP_011535117
VERSION     XP_011535117.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536815.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..174
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..174
                     /product="rRNA-processing protein FCF1 homolog isoform X1"
                     /calculated_mol_wt=20348
     Region          33..163
                     /region_name="PIN_Fcf1-like"
                     /note="VapC-like PIN domain of rRNA-processing protein,
                     Fcf1 (Utp24, YDR339C), and other eukaryotic homologs;
                     cd09864"
                     /db_xref="CDD:350212"
     Site            order(33,40..41,59,94..101)
                     /site_type="other"
                     /note="UTP 24 binding site [polypeptide binding]"
                     /db_xref="CDD:350212"
     CDS             1..174
                     /gene="FCF1"
                     /gene_synonym="Bka; C14orf111; CGI-35; UTP24"
                     /coded_by="XM_011536815.4:55..579"
                     /db_xref="GeneID:51077"
                     /db_xref="HGNC:HGNC:20220"
ORIGIN      
        1 mgkqkktrky atmkrmlslr dqrlpqhpsc lffqyntqlg ppyhilvdtn finfsikakl
       61 dlvqsmmdcl yakcipcitd cvmaeieklg qkyrvalria kdprferlpc thkgtyaddc
      121 lvqrvtqhkc yivatvdrdl krrirkipgv pimyisnhry niermpddyg aprf
//
LOCUS       XP_011535118             162 aa            linear   PRI 05-AUG-2025
DEFINITION  rRNA-processing protein FCF1 homolog isoform X2 [Homo sapiens].
ACCESSION   XP_011535118
VERSION     XP_011535118.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536816.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..162
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..162
                     /product="rRNA-processing protein FCF1 homolog isoform X2"
                     /calculated_mol_wt=18926
     Region          21..151
                     /region_name="PIN_Fcf1-like"
                     /note="VapC-like PIN domain of rRNA-processing protein,
                     Fcf1 (Utp24, YDR339C), and other eukaryotic homologs;
                     cd09864"
                     /db_xref="CDD:350212"
     Site            order(21,28..29,47,82..89)
                     /site_type="other"
                     /note="UTP 24 binding site [polypeptide binding]"
                     /db_xref="CDD:350212"
     CDS             1..162
                     /gene="FCF1"
                     /gene_synonym="Bka; C14orf111; CGI-35; UTP24"
                     /coded_by="XM_011536816.4:150..638"
                     /db_xref="GeneID:51077"
                     /db_xref="HGNC:HGNC:20220"
ORIGIN      
        1 mkrmlslrdq rlpqhpsclf fqyntqlgpp yhilvdtnfi nfsikakldl vqsmmdclya
       61 kcipcitdcv maeieklgqk yrvalriakd prferlpcth kgtyaddclv qrvtqhkcyi
      121 vatvdrdlkr rirkipgvpi myisnhryni ermpddygap rf
//
LOCUS       XP_016876842             484 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Z-dependent protease inhibitor isoform X1 [Homo sapiens].
ACCESSION   XP_016876842
VERSION     XP_016876842.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021353.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..484
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..484
                     /product="protein Z-dependent protease inhibitor isoform
                     X1"
                     /calculated_mol_wt=54983
     Region          107..482
                     /region_name="serpinA10_PZI"
                     /note="serpin family A member 10, protein Z-dependent
                     protease inhibitor; cd02055"
                     /db_xref="CDD:381011"
     Site            order(128..129,131..132,135,299..301,322..323,346,
                     348..351,354..355)
                     /site_type="other"
                     /note="protein Z binding site [polypeptide binding]"
                     /db_xref="CDD:381011"
     Site            order(434..444,451..459)
                     /site_type="other"
                     /note="reactive center loop (RCL)"
                     /db_xref="CDD:381011"
     CDS             1..484
                     /gene="SERPINA10"
                     /gene_synonym="PZI; ZPI"
                     /coded_by="XM_017021353.2:213..1667"
                     /db_xref="GeneID:51156"
                     /db_xref="HGNC:HGNC:15996"
                     /db_xref="MIM:605271"
ORIGIN      
        1 msrstqellg yhcrlqdklq eqegslaaeg rhslasaadh mkvvpsllls vllaqvwlvp
       61 glapspqspe tpapqnqtsr vvqapkeeee deqeaseeka seeekawlma srqqlakets
      121 nfgfsllrki smrhdgnmvf spfgmslamt glmlgatgpt etqikrglhl qalkptkpgl
      181 lpslfkglre tlsrnlelgl tqgsfafihk dfdvketffn lskryfdtec vpmnfrnasq
      241 akrlmnhyin ketrgkipkl fdeinpetkl ilvdyilfkg kwltpfdpvf tevdtfhldk
      301 yktikvpmmy gagkfastfd knfrchvlkl pyqgnatmlv vlmekmgdhl aledylttdl
      361 vetwlrnmkt rnmevffpkf kldqkyemhe llrqmgirri fspfadlsel satgrnlqvs
      421 rvlqrtviev dergteavag ilseitaysm ppvikvdrpf hfmiyeetsg mllflgrvvn
      481 ptll
//
LOCUS       XP_005267790             444 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Z-dependent protease inhibitor isoform X2 [Homo sapiens].
ACCESSION   XP_005267790
VERSION     XP_005267790.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267733.6
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..444
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..444
                     /product="protein Z-dependent protease inhibitor isoform
                     X2"
                     /calculated_mol_wt=50576
     Region          67..442
                     /region_name="serpinA10_PZI"
                     /note="serpin family A member 10, protein Z-dependent
                     protease inhibitor; cd02055"
                     /db_xref="CDD:381011"
     Site            order(88..89,91..92,95,259..261,282..283,306,308..311,
                     314..315)
                     /site_type="other"
                     /note="protein Z binding site [polypeptide binding]"
                     /db_xref="CDD:381011"
     Site            order(394..404,411..419)
                     /site_type="other"
                     /note="reactive center loop (RCL)"
                     /db_xref="CDD:381011"
     CDS             1..444
                     /gene="SERPINA10"
                     /gene_synonym="PZI; ZPI"
                     /coded_by="XM_005267733.6:305..1639"
                     /db_xref="GeneID:51156"
                     /db_xref="HGNC:HGNC:15996"
                     /db_xref="MIM:605271"
ORIGIN      
        1 mkvvpsllls vllaqvwlvp glapspqspe tpapqnqtsr vvqapkeeee deqeaseeka
       61 seeekawlma srqqlakets nfgfsllrki smrhdgnmvf spfgmslamt glmlgatgpt
      121 etqikrglhl qalkptkpgl lpslfkglre tlsrnlelgl tqgsfafihk dfdvketffn
      181 lskryfdtec vpmnfrnasq akrlmnhyin ketrgkipkl fdeinpetkl ilvdyilfkg
      241 kwltpfdpvf tevdtfhldk yktikvpmmy gagkfastfd knfrchvlkl pyqgnatmlv
      301 vlmekmgdhl aledylttdl vetwlrnmkt rnmevffpkf kldqkyemhe llrqmgirri
      361 fspfadlsel satgrnlqvs rvlqrtviev dergteavag ilseitaysm ppvikvdrpf
      421 hfmiyeetsg mllflgrvvn ptll
//
LOCUS       XP_024305390            2163 aa            linear   PRI 05-AUG-2025
DEFINITION  ninein isoform X1 [Homo sapiens].
ACCESSION   XP_024305390
VERSION     XP_024305390.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449622.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2163
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2163
                     /product="ninein isoform X1"
                     /calculated_mol_wt=251176
     Region          <437..855
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          <686..>1233
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          <1462..>2125
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..2163
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /coded_by="XM_024449622.2:233..6724"
                     /db_xref="GeneID:51199"
                     /db_xref="HGNC:HGNC:14906"
                     /db_xref="MIM:608684"
ORIGIN      
        1 mdeveqdqhe arlkelfdsf dttgtgslgq eeltdlchml sleevapvlq qtllqdnllg
       61 rvhfdqfkea lililsrtls neehfqepas vgvscqqvar vsgpllnghk lthcllikdc
      121 sleaqpkyvr ggkrygrrsl pefqesveef pevtviepld eearpshipa gdcsehwktq
      181 rseeyeaegq lrfwnpddln asqsgssppq dwieeklqev cedlgitrdg hlnrkklvsi
      241 ceqyglqnvd gemleevfhn ldpdgtmsve dffyglfkng ksltpsastp yrqlkrhlsm
      301 qsfdesgrrt ttssamtsti gfrvfscldd gmghasveri ldtwqeegie nsqeilkald
      361 fsldgninlt eltlalenel lvtknsihqa alasfkaeir hllervdqvv rekeklrsdl
      421 dkaeklkslm asevddhhaa ierrneynlr kldeeykeri aalknelrke reqilqqagk
      481 qrleleqeie kakteenyir drlalslken srlenellen aeklaeyenl tnklqrnlen
      541 vlaekfgdld pssaefflqe erltqmrney erqcrvlqdq vdelqselee yraqgrvlrl
      601 plknspseev eansggiepe hglgseecnp lnmsieaelv ieqmkeqhhr dicclrlele
      661 dkvrhyekql detvvsckka qenmkqrhen ethtlekqis dlkneiaelq gqaavlkeah
      721 heatcrheee kkqlqvklee ekthlqeklr lqhemelkar ltqaqasfer ereglqssaw
      781 teekvrgltq eleqfhqeql tslvekhtle keelrkelle khqrelqegr ekmetecnrr
      841 tsqieaqfqs dcqkvterce salqslegry rqelkdlqeq qreeksqwef ekdeltqeca
      901 eaqellketl krekttslvl tqeremlekt ykehlnsmvv erqqllqdle dlrnvsetqq
      961 sllsdqilel ksshkrelre reevlcqaga seqlasqrle rlemehdqer qemmskllam
     1021 enihkatcet adreraemst eisrlqskik emqqatspls mlqsgcqvig eeevegdgal
     1081 sllqqgeqll eengdvllsl qraheqavke nvkmateisr lqqrlqklep glvmssclde
     1141 pateffgnta eqteqflqqn rtkqvegvtr rhvlsdledd evrdlgstgt ssvqrqevki
     1201 eeseasvegf selenseetr teswelknqi sqlqeqlmml cadcdrasek kqdllfdvsv
     1261 lkkklkmler ipeaspkykl lyedvsrend clqeelrmme trydealenn keltaevfrl
     1321 qdelkkmeev tetflsleks ydevkieneg lnvlvlrlqg kieklqesvv qrcdcclwea
     1381 slenleiepd gnilqlnqtl eecvprvrsv hhvieeckqe nqylegntql lekvkaheia
     1441 wlhgtiqthq erprvqnqvi leenttllgf qdkhfqhqat iaelelektk lqeltrklke
     1501 rvtilvkqkd vlshgekeee lkammhdlqi tcsemqqkve llryeseklq qensilrnei
     1561 ttlneedsis nlklgtlngs qeemwqktet vkqenaavqk mvenlkkqis elkiknqqld
     1621 lentelsqkn sqnqeklqel nqrltemlcq kekepgnsal eereqekfnl keelerckvq
     1681 sstlvsslea elsevkiqth ivqqenhllk delekmkqlh rcpdlsdfqq kissvlsyne
     1741 kllkekeals eelnscvdkl akssllehri atmkqeqksw ehqsaslksq lvasqekvqn
     1801 ledtvqnvnl qmsrmksdlr vtqqekealk qevmslhkql qnaggkswap eiathpsglh
     1861 nqqkrlswdk ldhlmneeqq llwqenerlq tmvqntkael thsrekvrql esnllpkhqk
     1921 hlnpsgtmnp teqeklslkr ecdqfqkeqs panrkvsqmn sleqeletih leneglkkkq
     1981 vkldeqlmem qhlrstatps psphawdlql lqqqacpmvp reqflqlqrq llqaerinqh
     2041 lqeelenrts etntpqgnqe qlvtvmeerm ieveqklklv krllqekvnq lkeqlckntk
     2101 adamvkdlyv enaqllkale vteqrqktae kknylleeki aslsnivrnl tpapltstpp
     2161 lrs
//
LOCUS       XP_047287387            2133 aa            linear   PRI 05-AUG-2025
DEFINITION  ninein isoform X2 [Homo sapiens].
ACCESSION   XP_047287387
VERSION     XP_047287387.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431431.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2133
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2133
                     /product="ninein isoform X2"
                     /calculated_mol_wt=247498
     Region          403..>1022
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          696..1637
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          <1432..>2095
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..2133
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /coded_by="XM_047431431.1:233..6634"
                     /db_xref="GeneID:51199"
                     /db_xref="HGNC:HGNC:14906"
                     /db_xref="MIM:608684"
ORIGIN      
        1 mdeveqdqhe arlkelfdsf dttgtgslgq eeltdlchml sleevapvlq qtllqdnllg
       61 rvhfdqfkea lililsrtls neehfqepas vgvscqqvar vsgpllnghk lthcllikdc
      121 sleaqpkyvr ggkrygrrsl pefqesveef pevtviepld eearpshipa gdcsehwktq
      181 rseeyeaegq lrfwnpddln asqsgssppq dwieeklqev cedlgitrdg hlnrkklvsi
      241 ceqyglqnvd gemleevfhn ldpdgtmsve dffyglfkng ksltpsastp yrqlkrhlsm
      301 qsfdesgrrt ttssamtsti gfrvfscldd gmghasveri ldtwqeegie nsqeilkald
      361 fsldgninlt eltlalenel lvtknsihqa alasfkaeir hllervdqvv rekeklrsdl
      421 dkaeklkslm asevddhhaa ierrneynlr kldeeykeri aalknelrke reqilqqagk
      481 qrleleqeie kakteenyir drlalslken srlenellen aeklaeyenl tnklqrnlen
      541 vlaekvlqdq vdelqselee yraqgrvlrl plknspseev eansggiepe hglgseecnp
      601 lnmsieaelv ieqmkeqhhr dicclrlele dkvrhyekql detvvsckka qenmkqrhen
      661 ethtlekqis dlkneiaelq gqaavlkeah heatcrheee kkqlqvklee ekthlqeklr
      721 lqhemelkar ltqaqasfer ereglqssaw teekvrgltq eleqfhqeql tslvekhtle
      781 keelrkelle khqrelqegr ekmetecnrr tsqieaqfqs dcqkvterce salqslegry
      841 rqelkdlqeq qreeksqwef ekdeltqeca eaqellketl krekttslvl tqeremlekt
      901 ykehlnsmvv erqqllqdle dlrnvsetqq sllsdqilel ksshkrelre reevlcqaga
      961 seqlasqrle rlemehdqer qemmskllam enihkatcet adreraemst eisrlqskik
     1021 emqqatspls mlqsgcqvig eeevegdgal sllqqgeqll eengdvllsl qraheqavke
     1081 nvkmateisr lqqrlqklep glvmssclde pateffgnta eqteqflqqn rtkqvegvtr
     1141 rhvlsdledd evrdlgstgt ssvqrqevki eeseasvegf selenseetr teswelknqi
     1201 sqlqeqlmml cadcdrasek kqdllfdvsv lkkklkmler ipeaspkykl lyedvsrend
     1261 clqeelrmme trydealenn keltaevfrl qdelkkmeev tetflsleks ydevkieneg
     1321 lnvlvlrlqg kieklqesvv qrcdcclwea slenleiepd gnilqlnqtl eecvprvrsv
     1381 hhvieeckqe nqylegntql lekvkaheia wlhgtiqthq erprvqnqvi leenttllgf
     1441 qdkhfqhqat iaelelektk lqeltrklke rvtilvkqkd vlshgekeee lkammhdlqi
     1501 tcsemqqkve llryeseklq qensilrnei ttlneedsis nlklgtlngs qeemwqktet
     1561 vkqenaavqk mvenlkkqis elkiknqqld lentelsqkn sqnqeklqel nqrltemlcq
     1621 kekepgnsal eereqekfnl keelerckvq sstlvsslea elsevkiqth ivqqenhllk
     1681 delekmkqlh rcpdlsdfqq kissvlsyne kllkekeals eelnscvdkl akssllehri
     1741 atmkqeqksw ehqsaslksq lvasqekvqn ledtvqnvnl qmsrmksdlr vtqqekealk
     1801 qevmslhkql qnaggkswap eiathpsglh nqqkrlswdk ldhlmneeqq llwqenerlq
     1861 tmvqntkael thsrekvrql esnllpkhqk hlnpsgtmnp teqeklslkr ecdqfqkeqs
     1921 panrkvsqmn sleqeletih leneglkkkq vkldeqlmem qhlrstatps psphawdlql
     1981 lqqqacpmvp reqflqlqrq llqaerinqh lqeelenrts etntpqgnqe qlvtvmeerm
     2041 ieveqklklv krllqekvnq lkeqlckntk adamvkdlyv enaqllkale vteqrqktae
     2101 kknylleeki aslsnivrnl tpapltstpp lrs
//
LOCUS       XP_047287388            2103 aa            linear   PRI 05-AUG-2025
DEFINITION  ninein isoform X3 [Homo sapiens].
ACCESSION   XP_047287388
VERSION     XP_047287388.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431432.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2103
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2103
                     /product="ninein isoform X3"
                     /calculated_mol_wt=244386
     Region          373..>992
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          666..1607
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          <1402..>2065
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..2103
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /coded_by="XM_047431432.1:233..6544"
                     /db_xref="GeneID:51199"
                     /db_xref="HGNC:HGNC:14906"
                     /db_xref="MIM:608684"
ORIGIN      
        1 mdeveqdqhe arlkelfdsf dttgtgslgq eeltdlchml sleevapvlq qtllqdnllg
       61 rvhfdqfkea lililsrtls neehfqepdc sleaqpkyvr ggkrygrrsl pefqesveef
      121 pevtviepld eearpshipa gdcsehwktq rseeyeaegq lrfwnpddln asqsgssppq
      181 dwieeklqev cedlgitrdg hlnrkklvsi ceqyglqnvd gemleevfhn ldpdgtmsve
      241 dffyglfkng ksltpsastp yrqlkrhlsm qsfdesgrrt ttssamtsti gfrvfscldd
      301 gmghasveri ldtwqeegie nsqeilkald fsldgninlt eltlalenel lvtknsihqa
      361 alasfkaeir hllervdqvv rekeklrsdl dkaeklkslm asevddhhaa ierrneynlr
      421 kldeeykeri aalknelrke reqilqqagk qrleleqeie kakteenyir drlalslken
      481 srlenellen aeklaeyenl tnklqrnlen vlaekvlqdq vdelqselee yraqgrvlrl
      541 plknspseev eansggiepe hglgseecnp lnmsieaelv ieqmkeqhhr dicclrlele
      601 dkvrhyekql detvvsckka qenmkqrhen ethtlekqis dlkneiaelq gqaavlkeah
      661 heatcrheee kkqlqvklee ekthlqeklr lqhemelkar ltqaqasfer ereglqssaw
      721 teekvrgltq eleqfhqeql tslvekhtle keelrkelle khqrelqegr ekmetecnrr
      781 tsqieaqfqs dcqkvterce salqslegry rqelkdlqeq qreeksqwef ekdeltqeca
      841 eaqellketl krekttslvl tqeremlekt ykehlnsmvv erqqllqdle dlrnvsetqq
      901 sllsdqilel ksshkrelre reevlcqaga seqlasqrle rlemehdqer qemmskllam
      961 enihkatcet adreraemst eisrlqskik emqqatspls mlqsgcqvig eeevegdgal
     1021 sllqqgeqll eengdvllsl qraheqavke nvkmateisr lqqrlqklep glvmssclde
     1081 pateffgnta eqteqflqqn rtkqvegvtr rhvlsdledd evrdlgstgt ssvqrqevki
     1141 eeseasvegf selenseetr teswelknqi sqlqeqlmml cadcdrasek kqdllfdvsv
     1201 lkkklkmler ipeaspkykl lyedvsrend clqeelrmme trydealenn keltaevfrl
     1261 qdelkkmeev tetflsleks ydevkieneg lnvlvlrlqg kieklqesvv qrcdcclwea
     1321 slenleiepd gnilqlnqtl eecvprvrsv hhvieeckqe nqylegntql lekvkaheia
     1381 wlhgtiqthq erprvqnqvi leenttllgf qdkhfqhqat iaelelektk lqeltrklke
     1441 rvtilvkqkd vlshgekeee lkammhdlqi tcsemqqkve llryeseklq qensilrnei
     1501 ttlneedsis nlklgtlngs qeemwqktet vkqenaavqk mvenlkkqis elkiknqqld
     1561 lentelsqkn sqnqeklqel nqrltemlcq kekepgnsal eereqekfnl keelerckvq
     1621 sstlvsslea elsevkiqth ivqqenhllk delekmkqlh rcpdlsdfqq kissvlsyne
     1681 kllkekeals eelnscvdkl akssllehri atmkqeqksw ehqsaslksq lvasqekvqn
     1741 ledtvqnvnl qmsrmksdlr vtqqekealk qevmslhkql qnaggkswap eiathpsglh
     1801 nqqkrlswdk ldhlmneeqq llwqenerlq tmvqntkael thsrekvrql esnllpkhqk
     1861 hlnpsgtmnp teqeklslkr ecdqfqkeqs panrkvsqmn sleqeletih leneglkkkq
     1921 vkldeqlmem qhlrstatps psphawdlql lqqqacpmvp reqflqlqrq llqaerinqh
     1981 lqeelenrts etntpqgnqe qlvtvmeerm ieveqklklv krllqekvnq lkeqlckntk
     2041 adamvkdlyv enaqllkale vteqrqktae kknylleeki aslsnivrnl tpapltstpp
     2101 lrs
//
LOCUS       XP_047287389            2091 aa            linear   PRI 05-AUG-2025
DEFINITION  ninein isoform X4 [Homo sapiens].
ACCESSION   XP_047287389
VERSION     XP_047287389.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431433.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2091
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2091
                     /product="ninein isoform X4"
                     /calculated_mol_wt=242591
     Region          <437..855
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          <686..>1233
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          870..>1775
                     /region_name="CCDC158"
                     /note="Coiled-coil domain-containing protein 158;
                     pfam15921"
                     /db_xref="CDD:464943"
     Region          1555..>2071
                     /region_name="Mplasa_alph_rch"
                     /note="helix-rich Mycoplasma protein; TIGR04523"
                     /db_xref="CDD:275316"
     CDS             1..2091
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /coded_by="XM_047431433.1:233..6508"
                     /db_xref="GeneID:51199"
                     /db_xref="HGNC:HGNC:14906"
                     /db_xref="MIM:608684"
ORIGIN      
        1 mdeveqdqhe arlkelfdsf dttgtgslgq eeltdlchml sleevapvlq qtllqdnllg
       61 rvhfdqfkea lililsrtls neehfqepas vgvscqqvar vsgpllnghk lthcllikdc
      121 sleaqpkyvr ggkrygrrsl pefqesveef pevtviepld eearpshipa gdcsehwktq
      181 rseeyeaegq lrfwnpddln asqsgssppq dwieeklqev cedlgitrdg hlnrkklvsi
      241 ceqyglqnvd gemleevfhn ldpdgtmsve dffyglfkng ksltpsastp yrqlkrhlsm
      301 qsfdesgrrt ttssamtsti gfrvfscldd gmghasveri ldtwqeegie nsqeilkald
      361 fsldgninlt eltlalenel lvtknsihqa alasfkaeir hllervdqvv rekeklrsdl
      421 dkaeklkslm asevddhhaa ierrneynlr kldeeykeri aalknelrke reqilqqagk
      481 qrleleqeie kakteenyir drlalslken srlenellen aeklaeyenl tnklqrnlen
      541 vlaekfgdld pssaefflqe erltqmrney erqcrvlqdq vdelqselee yraqgrvlrl
      601 plknspseev eansggiepe hglgseecnp lnmsieaelv ieqmkeqhhr dicclrlele
      661 dkvrhyekql detvvsckka qenmkqrhen ethtlekqis dlkneiaelq gqaavlkeah
      721 heatcrheee kkqlqvklee ekthlqeklr lqhemelkar ltqaqasfer ereglqssaw
      781 teekvrgltq eleqfhqeql tslvekhtle keelrkelle khqrelqegr ekmetecnrr
      841 tsqieaqfqs dcqkvterce salqslegry rqelkdlqeq qreeksqwef ekdeltqeca
      901 eaqellketl krekttslvl tqeremlekt ykehlnsmvv erqqllqdle dlrnvsetqq
      961 sllsdqilel ksshkrelre reevlcqaga seqlasqrle rlemehdqer qemmskllam
     1021 enihkatcet adreraemst eisrlqskik emqqatspls mlqsgcqvig eeevegdgal
     1081 sllqqgeqll eengdvllsl qraheqavke nvkmateisr lqqrlqklep glvmssclde
     1141 pateffgnta eqteqflqqn rtkqvegvtr rhvlsdledd evrdlgstgt ssvqrqevki
     1201 eeseasvegf selenseetr teswelknqi sqlqeqlmml cadcdrasek kqdllfdvsv
     1261 lkkklkmler ipeaspkykl lyedvsrend clqeelrmme trydealenn keltaevfrl
     1321 qdelkkmeev tetflsleks ydevkieneg lnvlvlrlqg kieklqesvv qrcdcclwea
     1381 slenleiepd gnilqlnqtl eecvprvrsv hhvieeckqe nqylegntql lekvkaheia
     1441 wlhgtiqthq erprvqnqvi leenttllgf qdkhfqhqat iaelelektk lqeltrklke
     1501 rvtilvkqkd vlshgekeee lkammhdlqi tcsemqqkve llryeseklq qensilrnei
     1561 ttlneedsis nlklgtlngs qeemwqktet vkqenaavqk mvenlkkqss tlvssleael
     1621 sevkiqthiv qqenhllkde lekmkqlhrc pdlsdfqqki ssvlsynekl lkekealsee
     1681 lnscvdklak ssllehriat mkqeqksweh qsaslksqlv asqekvqnle dtvqnvnlqm
     1741 srmksdlrvt qqekealkqe vmslhkqlqn aggkswapei athpsglhnq qkrlswdkld
     1801 hlmneeqqll wqenerlqtm vqntkaelth srekvrqles nllpkhqkhl npsgtmnpte
     1861 qeklslkrec dqfqkeqspa nrkvsqmnsl eqeletihle neglkkkqvk ldeqlmemqh
     1921 lrstatpsps phawdlqllq qqacpmvpre qflqlqrqll qaerinqhlq eelenrtset
     1981 ntpqgnqeql vtvmeermie veqklklvkr llqekvnqlk eqlckntkad amvkdlyven
     2041 aqllkalevt eqrqktaekk nylleekias lsnivrnltp apltstpplr s
//
LOCUS       XP_011535121            2076 aa            linear   PRI 05-AUG-2025
DEFINITION  ninein isoform X5 [Homo sapiens].
ACCESSION   XP_011535121
VERSION     XP_011535121.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536819.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2076
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2076
                     /product="ninein isoform X5"
                     /calculated_mol_wt=241175
     Region          <437..855
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          <686..>1233
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          <1476..1847
                     /region_name="Mplasa_alph_rch"
                     /note="helix-rich Mycoplasma protein; TIGR04523"
                     /db_xref="CDD:275316"
     Region          1766..>1967
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..2076
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /coded_by="XM_011536819.4:233..6463"
                     /db_xref="GeneID:51199"
                     /db_xref="HGNC:HGNC:14906"
                     /db_xref="MIM:608684"
ORIGIN      
        1 mdeveqdqhe arlkelfdsf dttgtgslgq eeltdlchml sleevapvlq qtllqdnllg
       61 rvhfdqfkea lililsrtls neehfqepas vgvscqqvar vsgpllnghk lthcllikdc
      121 sleaqpkyvr ggkrygrrsl pefqesveef pevtviepld eearpshipa gdcsehwktq
      181 rseeyeaegq lrfwnpddln asqsgssppq dwieeklqev cedlgitrdg hlnrkklvsi
      241 ceqyglqnvd gemleevfhn ldpdgtmsve dffyglfkng ksltpsastp yrqlkrhlsm
      301 qsfdesgrrt ttssamtsti gfrvfscldd gmghasveri ldtwqeegie nsqeilkald
      361 fsldgninlt eltlalenel lvtknsihqa alasfkaeir hllervdqvv rekeklrsdl
      421 dkaeklkslm asevddhhaa ierrneynlr kldeeykeri aalknelrke reqilqqagk
      481 qrleleqeie kakteenyir drlalslken srlenellen aeklaeyenl tnklqrnlen
      541 vlaekfgdld pssaefflqe erltqmrney erqcrvlqdq vdelqselee yraqgrvlrl
      601 plknspseev eansggiepe hglgseecnp lnmsieaelv ieqmkeqhhr dicclrlele
      661 dkvrhyekql detvvsckka qenmkqrhen ethtlekqis dlkneiaelq gqaavlkeah
      721 heatcrheee kkqlqvklee ekthlqeklr lqhemelkar ltqaqasfer ereglqssaw
      781 teekvrgltq eleqfhqeql tslvekhtle keelrkelle khqrelqegr ekmetecnrr
      841 tsqieaqfqs dcqkvterce salqslegry rqelkdlqeq qreeksqwef ekdeltqeca
      901 eaqellketl krekttslvl tqeremlekt ykehlnsmvv erqqllqdle dlrnvsetqq
      961 sllsdqilel ksshkrelre reevlcqaga seqlasqrle rlemehdqer qemmskllam
     1021 enihkatcet adreraemst eisrlqskik emqqatspls mlqsgcqvig eeevegdgal
     1081 sllqqgeqll eengdvllsl qraheqavke nvkmateisr lqqrlqklep glvmssclde
     1141 pateffgnta eqteqflqqn rtkqvegvtr rhvlsdledd evrdlgstgt ssvqrqevki
     1201 eeseasvegf selenseetr teswelknqi sqlqeqlmml cadcdrasek kqdllfdvsv
     1261 lkkklkmler ipeaspkykl lyedvsrend clqeelrmme trydealenn keltaevfrl
     1321 qdelkkmeev tetflsleks ydevkieneg lnvlvlrlqg kieklqesvv qrcdcclwea
     1381 slenleiepd gnilqlnqtl eecvprvrsv hhvieeckqe nqylegntql lekvkaheia
     1441 wlhgtiqthq erprvqnqvi leenttllgf qdkhfqhqat iaelelektk lqeltrklke
     1501 rvtilvkqkd vlshgekeee lkammhdlqi tcsemqqkve llryeseklq qensilrnei
     1561 ttlneedsis nlklgtlngs qeemwqktet vkqenaavqk mvenlkkqis elkiknqqld
     1621 lentelsqkn sqnqeklqel nqrltemlcq kekepgnsal eereqekfnl keelerckvq
     1681 sstlvsslea elsevkiqth ivqqenhllk delekmkqlh rcpdlsdfqq kissvlsyne
     1741 kllkekeals eelnscvdkl akssllehri atmkqeqksw ehqsaslksq lvasqekvqn
     1801 ledtvqnvnl qmsrmksdlr vtqqekealk qevmslhkql qnaggkswap eiathpsglh
     1861 nqqkrlswdk ldhlmneeqq llwqenerlq tmvqntkael thsrekvrql esnllpkhqk
     1921 hlnpsgtmnp teqeklslkr ecdqfqkeqs panrkvsqmn sleqeletih leneglkkkq
     1981 vkldeqlmem qhlrstatps psphawdlql lqqqacpmvp reqflqlqrq llqaerinqh
     2041 lqeelenrts etntpqallp eqravhadsy rrighl
//
LOCUS       XP_047287390            2061 aa            linear   PRI 05-AUG-2025
DEFINITION  ninein isoform X6 [Homo sapiens].
ACCESSION   XP_047287390
VERSION     XP_047287390.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431434.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2061
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2061
                     /product="ninein isoform X6"
                     /calculated_mol_wt=239479
     Region          <407..825
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          <656..>1203
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          840..>1745
                     /region_name="CCDC158"
                     /note="Coiled-coil domain-containing protein 158;
                     pfam15921"
                     /db_xref="CDD:464943"
     Region          1525..>2041
                     /region_name="Mplasa_alph_rch"
                     /note="helix-rich Mycoplasma protein; TIGR04523"
                     /db_xref="CDD:275316"
     CDS             1..2061
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /coded_by="XM_047431434.1:233..6418"
                     /db_xref="GeneID:51199"
                     /db_xref="HGNC:HGNC:14906"
                     /db_xref="MIM:608684"
ORIGIN      
        1 mdeveqdqhe arlkelfdsf dttgtgslgq eeltdlchml sleevapvlq qtllqdnllg
       61 rvhfdqfkea lililsrtls neehfqepdc sleaqpkyvr ggkrygrrsl pefqesveef
      121 pevtviepld eearpshipa gdcsehwktq rseeyeaegq lrfwnpddln asqsgssppq
      181 dwieeklqev cedlgitrdg hlnrkklvsi ceqyglqnvd gemleevfhn ldpdgtmsve
      241 dffyglfkng ksltpsastp yrqlkrhlsm qsfdesgrrt ttssamtsti gfrvfscldd
      301 gmghasveri ldtwqeegie nsqeilkald fsldgninlt eltlalenel lvtknsihqa
      361 alasfkaeir hllervdqvv rekeklrsdl dkaeklkslm asevddhhaa ierrneynlr
      421 kldeeykeri aalknelrke reqilqqagk qrleleqeie kakteenyir drlalslken
      481 srlenellen aeklaeyenl tnklqrnlen vlaekfgdld pssaefflqe erltqmrney
      541 erqcrvlqdq vdelqselee yraqgrvlrl plknspseev eansggiepe hglgseecnp
      601 lnmsieaelv ieqmkeqhhr dicclrlele dkvrhyekql detvvsckka qenmkqrhen
      661 ethtlekqis dlkneiaelq gqaavlkeah heatcrheee kkqlqvklee ekthlqeklr
      721 lqhemelkar ltqaqasfer ereglqssaw teekvrgltq eleqfhqeql tslvekhtle
      781 keelrkelle khqrelqegr ekmetecnrr tsqieaqfqs dcqkvterce salqslegry
      841 rqelkdlqeq qreeksqwef ekdeltqeca eaqellketl krekttslvl tqeremlekt
      901 ykehlnsmvv erqqllqdle dlrnvsetqq sllsdqilel ksshkrelre reevlcqaga
      961 seqlasqrle rlemehdqer qemmskllam enihkatcet adreraemst eisrlqskik
     1021 emqqatspls mlqsgcqvig eeevegdgal sllqqgeqll eengdvllsl qraheqavke
     1081 nvkmateisr lqqrlqklep glvmssclde pateffgnta eqteqflqqn rtkqvegvtr
     1141 rhvlsdledd evrdlgstgt ssvqrqevki eeseasvegf selenseetr teswelknqi
     1201 sqlqeqlmml cadcdrasek kqdllfdvsv lkkklkmler ipeaspkykl lyedvsrend
     1261 clqeelrmme trydealenn keltaevfrl qdelkkmeev tetflsleks ydevkieneg
     1321 lnvlvlrlqg kieklqesvv qrcdcclwea slenleiepd gnilqlnqtl eecvprvrsv
     1381 hhvieeckqe nqylegntql lekvkaheia wlhgtiqthq erprvqnqvi leenttllgf
     1441 qdkhfqhqat iaelelektk lqeltrklke rvtilvkqkd vlshgekeee lkammhdlqi
     1501 tcsemqqkve llryeseklq qensilrnei ttlneedsis nlklgtlngs qeemwqktet
     1561 vkqenaavqk mvenlkkqss tlvssleael sevkiqthiv qqenhllkde lekmkqlhrc
     1621 pdlsdfqqki ssvlsynekl lkekealsee lnscvdklak ssllehriat mkqeqksweh
     1681 qsaslksqlv asqekvqnle dtvqnvnlqm srmksdlrvt qqekealkqe vmslhkqlqn
     1741 aggkswapei athpsglhnq qkrlswdkld hlmneeqqll wqenerlqtm vqntkaelth
     1801 srekvrqles nllpkhqkhl npsgtmnpte qeklslkrec dqfqkeqspa nrkvsqmnsl
     1861 eqeletihle neglkkkqvk ldeqlmemqh lrstatpsps phawdlqllq qqacpmvpre
     1921 qflqlqrqll qaerinqhlq eelenrtset ntpqgnqeql vtvmeermie veqklklvkr
     1981 llqekvnqlk eqlckntkad amvkdlyven aqllkalevt eqrqktaekk nylleekias
     2041 lsnivrnltp apltstpplr s
//
LOCUS       XP_047287391            2046 aa            linear   PRI 05-AUG-2025
DEFINITION  ninein isoform X7 [Homo sapiens].
ACCESSION   XP_047287391
VERSION     XP_047287391.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431435.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2046
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2046
                     /product="ninein isoform X7"
                     /calculated_mol_wt=237497
     Region          403..>1022
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          696..1637
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          1508..>1957
                     /region_name="Mplasa_alph_rch"
                     /note="helix-rich Mycoplasma protein; TIGR04523"
                     /db_xref="CDD:275316"
     CDS             1..2046
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /coded_by="XM_047431435.1:233..6373"
                     /db_xref="GeneID:51199"
                     /db_xref="HGNC:HGNC:14906"
                     /db_xref="MIM:608684"
ORIGIN      
        1 mdeveqdqhe arlkelfdsf dttgtgslgq eeltdlchml sleevapvlq qtllqdnllg
       61 rvhfdqfkea lililsrtls neehfqepas vgvscqqvar vsgpllnghk lthcllikdc
      121 sleaqpkyvr ggkrygrrsl pefqesveef pevtviepld eearpshipa gdcsehwktq
      181 rseeyeaegq lrfwnpddln asqsgssppq dwieeklqev cedlgitrdg hlnrkklvsi
      241 ceqyglqnvd gemleevfhn ldpdgtmsve dffyglfkng ksltpsastp yrqlkrhlsm
      301 qsfdesgrrt ttssamtsti gfrvfscldd gmghasveri ldtwqeegie nsqeilkald
      361 fsldgninlt eltlalenel lvtknsihqa alasfkaeir hllervdqvv rekeklrsdl
      421 dkaeklkslm asevddhhaa ierrneynlr kldeeykeri aalknelrke reqilqqagk
      481 qrleleqeie kakteenyir drlalslken srlenellen aeklaeyenl tnklqrnlen
      541 vlaekvlqdq vdelqselee yraqgrvlrl plknspseev eansggiepe hglgseecnp
      601 lnmsieaelv ieqmkeqhhr dicclrlele dkvrhyekql detvvsckka qenmkqrhen
      661 ethtlekqis dlkneiaelq gqaavlkeah heatcrheee kkqlqvklee ekthlqeklr
      721 lqhemelkar ltqaqasfer ereglqssaw teekvrgltq eleqfhqeql tslvekhtle
      781 keelrkelle khqrelqegr ekmetecnrr tsqieaqfqs dcqkvterce salqslegry
      841 rqelkdlqeq qreeksqwef ekdeltqeca eaqellketl krekttslvl tqeremlekt
      901 ykehlnsmvv erqqllqdle dlrnvsetqq sllsdqilel ksshkrelre reevlcqaga
      961 seqlasqrle rlemehdqer qemmskllam enihkatcet adreraemst eisrlqskik
     1021 emqqatspls mlqsgcqvig eeevegdgal sllqqgeqll eengdvllsl qraheqavke
     1081 nvkmateisr lqqrlqklep glvmssclde pateffgnta eqteqflqqn rtkqvegvtr
     1141 rhvlsdledd evrdlgstgt ssvqrqevki eeseasvegf selenseetr teswelknqi
     1201 sqlqeqlmml cadcdrasek kqdllfdvsv lkkklkmler ipeaspkykl lyedvsrend
     1261 clqeelrmme trydealenn keltaevfrl qdelkkmeev tetflsleks ydevkieneg
     1321 lnvlvlrlqg kieklqesvv qrcdcclwea slenleiepd gnilqlnqtl eecvprvrsv
     1381 hhvieeckqe nqylegntql lekvkaheia wlhgtiqthq erprvqnqvi leenttllgf
     1441 qdkhfqhqat iaelelektk lqeltrklke rvtilvkqkd vlshgekeee lkammhdlqi
     1501 tcsemqqkve llryeseklq qensilrnei ttlneedsis nlklgtlngs qeemwqktet
     1561 vkqenaavqk mvenlkkqis elkiknqqld lentelsqkn sqnqeklqel nqrltemlcq
     1621 kekepgnsal eereqekfnl keelerckvq sstlvsslea elsevkiqth ivqqenhllk
     1681 delekmkqlh rcpdlsdfqq kissvlsyne kllkekeals eelnscvdkl akssllehri
     1741 atmkqeqksw ehqsaslksq lvasqekvqn ledtvqnvnl qmsrmksdlr vtqqekealk
     1801 qevmslhkql qnaggkswap eiathpsglh nqqkrlswdk ldhlmneeqq llwqenerlq
     1861 tmvqntkael thsrekvrql esnllpkhqk hlnpsgtmnp teqeklslkr ecdqfqkeqs
     1921 panrkvsqmn sleqeletih leneglkkkq vkldeqlmem qhlrstatps psphawdlql
     1981 lqqqacpmvp reqflqlqrq llqaerinqh lqeelenrts etntpqallp eqravhadsy
     2041 rrighl
//
LOCUS       XP_047287392            2019 aa            linear   PRI 05-AUG-2025
DEFINITION  ninein isoform X8 [Homo sapiens].
ACCESSION   XP_047287392
VERSION     XP_047287392.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431436.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2019
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2019
                     /product="ninein isoform X8"
                     /calculated_mol_wt=234080
     Region          <437..855
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          <686..>1233
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          <1476..1847
                     /region_name="Mplasa_alph_rch"
                     /note="helix-rich Mycoplasma protein; TIGR04523"
                     /db_xref="CDD:275316"
     Region          1766..>1967
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..2019
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /coded_by="XM_047431436.1:233..6292"
                     /db_xref="GeneID:51199"
                     /db_xref="HGNC:HGNC:14906"
                     /db_xref="MIM:608684"
ORIGIN      
        1 mdeveqdqhe arlkelfdsf dttgtgslgq eeltdlchml sleevapvlq qtllqdnllg
       61 rvhfdqfkea lililsrtls neehfqepas vgvscqqvar vsgpllnghk lthcllikdc
      121 sleaqpkyvr ggkrygrrsl pefqesveef pevtviepld eearpshipa gdcsehwktq
      181 rseeyeaegq lrfwnpddln asqsgssppq dwieeklqev cedlgitrdg hlnrkklvsi
      241 ceqyglqnvd gemleevfhn ldpdgtmsve dffyglfkng ksltpsastp yrqlkrhlsm
      301 qsfdesgrrt ttssamtsti gfrvfscldd gmghasveri ldtwqeegie nsqeilkald
      361 fsldgninlt eltlalenel lvtknsihqa alasfkaeir hllervdqvv rekeklrsdl
      421 dkaeklkslm asevddhhaa ierrneynlr kldeeykeri aalknelrke reqilqqagk
      481 qrleleqeie kakteenyir drlalslken srlenellen aeklaeyenl tnklqrnlen
      541 vlaekfgdld pssaefflqe erltqmrney erqcrvlqdq vdelqselee yraqgrvlrl
      601 plknspseev eansggiepe hglgseecnp lnmsieaelv ieqmkeqhhr dicclrlele
      661 dkvrhyekql detvvsckka qenmkqrhen ethtlekqis dlkneiaelq gqaavlkeah
      721 heatcrheee kkqlqvklee ekthlqeklr lqhemelkar ltqaqasfer ereglqssaw
      781 teekvrgltq eleqfhqeql tslvekhtle keelrkelle khqrelqegr ekmetecnrr
      841 tsqieaqfqs dcqkvterce salqslegry rqelkdlqeq qreeksqwef ekdeltqeca
      901 eaqellketl krekttslvl tqeremlekt ykehlnsmvv erqqllqdle dlrnvsetqq
      961 sllsdqilel ksshkrelre reevlcqaga seqlasqrle rlemehdqer qemmskllam
     1021 enihkatcet adreraemst eisrlqskik emqqatspls mlqsgcqvig eeevegdgal
     1081 sllqqgeqll eengdvllsl qraheqavke nvkmateisr lqqrlqklep glvmssclde
     1141 pateffgnta eqteqflqqn rtkqvegvtr rhvlsdledd evrdlgstgt ssvqrqevki
     1201 eeseasvegf selenseetr teswelknqi sqlqeqlmml cadcdrasek kqdllfdvsv
     1261 lkkklkmler ipeaspkykl lyedvsrend clqeelrmme trydealenn keltaevfrl
     1321 qdelkkmeev tetflsleks ydevkieneg lnvlvlrlqg kieklqesvv qrcdcclwea
     1381 slenleiepd gnilqlnqtl eecvprvrsv hhvieeckqe nqylegntql lekvkaheia
     1441 wlhgtiqthq erprvqnqvi leenttllgf qdkhfqhqat iaelelektk lqeltrklke
     1501 rvtilvkqkd vlshgekeee lkammhdlqi tcsemqqkve llryeseklq qensilrnei
     1561 ttlneedsis nlklgtlngs qeemwqktet vkqenaavqk mvenlkkqis elkiknqqld
     1621 lentelsqkn sqnqeklqel nqrltemlcq kekepgnsal eereqekfnl keelerckvq
     1681 sstlvsslea elsevkiqth ivqqenhllk delekmkqlh rcpdlsdfqq kissvlsyne
     1741 kllkekeals eelnscvdkl akssllehri atmkqeqksw ehqsaslksq lvasqekvqn
     1801 ledtvqnvnl qmsrmksdlr vtqqekealk qevmslhkql qnaggkswap eiathpsglh
     1861 nqqkrlswdk ldhlmneeqq llwqenerlq tmvqntkael thsrekvrql esnllpkhqk
     1921 hlnpsgtmnp teqeklslkr ecdqfqkeqs panrkvsqmn sleqeletih leneglkkkq
     1981 vkldeqlmen svvgssregc sslpeivced aapevhcda
//
LOCUS       XP_047287393            1989 aa            linear   PRI 05-AUG-2025
DEFINITION  ninein isoform X9 [Homo sapiens].
ACCESSION   XP_047287393
VERSION     XP_047287393.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431437.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1989
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1989
                     /product="ninein isoform X9"
                     /calculated_mol_wt=230968
     Region          <407..825
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          <656..>1203
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          <1446..1817
                     /region_name="Mplasa_alph_rch"
                     /note="helix-rich Mycoplasma protein; TIGR04523"
                     /db_xref="CDD:275316"
     Region          1736..>1937
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..1989
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /coded_by="XM_047431437.1:233..6202"
                     /db_xref="GeneID:51199"
                     /db_xref="HGNC:HGNC:14906"
                     /db_xref="MIM:608684"
ORIGIN      
        1 mdeveqdqhe arlkelfdsf dttgtgslgq eeltdlchml sleevapvlq qtllqdnllg
       61 rvhfdqfkea lililsrtls neehfqepdc sleaqpkyvr ggkrygrrsl pefqesveef
      121 pevtviepld eearpshipa gdcsehwktq rseeyeaegq lrfwnpddln asqsgssppq
      181 dwieeklqev cedlgitrdg hlnrkklvsi ceqyglqnvd gemleevfhn ldpdgtmsve
      241 dffyglfkng ksltpsastp yrqlkrhlsm qsfdesgrrt ttssamtsti gfrvfscldd
      301 gmghasveri ldtwqeegie nsqeilkald fsldgninlt eltlalenel lvtknsihqa
      361 alasfkaeir hllervdqvv rekeklrsdl dkaeklkslm asevddhhaa ierrneynlr
      421 kldeeykeri aalknelrke reqilqqagk qrleleqeie kakteenyir drlalslken
      481 srlenellen aeklaeyenl tnklqrnlen vlaekfgdld pssaefflqe erltqmrney
      541 erqcrvlqdq vdelqselee yraqgrvlrl plknspseev eansggiepe hglgseecnp
      601 lnmsieaelv ieqmkeqhhr dicclrlele dkvrhyekql detvvsckka qenmkqrhen
      661 ethtlekqis dlkneiaelq gqaavlkeah heatcrheee kkqlqvklee ekthlqeklr
      721 lqhemelkar ltqaqasfer ereglqssaw teekvrgltq eleqfhqeql tslvekhtle
      781 keelrkelle khqrelqegr ekmetecnrr tsqieaqfqs dcqkvterce salqslegry
      841 rqelkdlqeq qreeksqwef ekdeltqeca eaqellketl krekttslvl tqeremlekt
      901 ykehlnsmvv erqqllqdle dlrnvsetqq sllsdqilel ksshkrelre reevlcqaga
      961 seqlasqrle rlemehdqer qemmskllam enihkatcet adreraemst eisrlqskik
     1021 emqqatspls mlqsgcqvig eeevegdgal sllqqgeqll eengdvllsl qraheqavke
     1081 nvkmateisr lqqrlqklep glvmssclde pateffgnta eqteqflqqn rtkqvegvtr
     1141 rhvlsdledd evrdlgstgt ssvqrqevki eeseasvegf selenseetr teswelknqi
     1201 sqlqeqlmml cadcdrasek kqdllfdvsv lkkklkmler ipeaspkykl lyedvsrend
     1261 clqeelrmme trydealenn keltaevfrl qdelkkmeev tetflsleks ydevkieneg
     1321 lnvlvlrlqg kieklqesvv qrcdcclwea slenleiepd gnilqlnqtl eecvprvrsv
     1381 hhvieeckqe nqylegntql lekvkaheia wlhgtiqthq erprvqnqvi leenttllgf
     1441 qdkhfqhqat iaelelektk lqeltrklke rvtilvkqkd vlshgekeee lkammhdlqi
     1501 tcsemqqkve llryeseklq qensilrnei ttlneedsis nlklgtlngs qeemwqktet
     1561 vkqenaavqk mvenlkkqis elkiknqqld lentelsqkn sqnqeklqel nqrltemlcq
     1621 kekepgnsal eereqekfnl keelerckvq sstlvsslea elsevkiqth ivqqenhllk
     1681 delekmkqlh rcpdlsdfqq kissvlsyne kllkekeals eelnscvdkl akssllehri
     1741 atmkqeqksw ehqsaslksq lvasqekvqn ledtvqnvnl qmsrmksdlr vtqqekealk
     1801 qevmslhkql qnaggkswap eiathpsglh nqqkrlswdk ldhlmneeqq llwqenerlq
     1861 tmvqntkael thsrekvrql esnllpkhqk hlnpsgtmnp teqeklslkr ecdqfqkeqs
     1921 panrkvsqmn sleqeletih leneglkkkq vkldeqlmen svvgssregc sslpeivced
     1981 aapevhcda
//
LOCUS       XP_047287394            1911 aa            linear   PRI 05-AUG-2025
DEFINITION  ninein isoform X10 [Homo sapiens].
ACCESSION   XP_047287394
VERSION     XP_047287394.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431438.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1911
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1911
                     /product="ninein isoform X10"
                     /calculated_mol_wt=222638
     Region          <85..>285
                     /region_name="GumC"
                     /note="Exopolysaccharide export protein/domain GumC/Wzc1
                     [Cell wall/membrane/envelope biogenesis]; COG3206"
                     /db_xref="CDD:442439"
     Region          <202..603
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          <434..>981
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          <1210..>1873
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1911
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /coded_by="XM_047431438.1:695..6430"
                     /db_xref="GeneID:51199"
                     /db_xref="HGNC:HGNC:14906"
                     /db_xref="MIM:608684"
ORIGIN      
        1 mleevfhnld pdgtmsvedf fyglfkngks ltpsastpyr qlkrhlsmqs fdesgrrttt
       61 ssamtstigf rvfsclddgm ghasverild twqeegiens qeilkaldfs ldgninltel
      121 tlalenellv tknsihqaal asfkaeirhl lervdqvvre keklrsdldk aeklkslmas
      181 evddhhaaie rrneynlrkl deeykeriaa lknelrkere qilqqagkqr leleqeieka
      241 kteenyirdr lalslkensr lenellenae klaeyenltn klqrnlenvl aekfgdldps
      301 saefflqeer ltqmrneyer qcrvlqdqvd elqseleeyr aqgrvlrlpl knspseevea
      361 nsggiepehg lgseecnpln msieaelvie qmkeqhhrdi cclrleledk vrhyekqlde
      421 tvvsckkaqe nmkqrhenet htlekqisdl kneiaelqgq aavlkeahhe atcrheeekk
      481 qlqvkleeek thlqeklrlq hemelkarlt qaqasferer eglqssawte ekvrgltqel
      541 eqfhqeqlts lvekhtleke elrkellekh qrelqegrek metecnrrts qieaqfqsdc
      601 qkvtercesa lqslegryrq elkdlqeqqr eeksqwefek deltqecaea qellketlkr
      661 ekttslvltq eremlektyk ehlnsmvver qqllqdledl rnvsetqqsl lsdqilelks
      721 shkrelrere evlcqagase qlasqrlerl emehdqerqe mmskllamen ihkatcetad
      781 reraemstei srlqskikem qqatsplsml qsgcqvigee evegdgalsl lqqgeqllee
      841 ngdvllslqr aheqavkenv kmateisrlq qrlqklepgl vmsscldepa teffgntaeq
      901 teqflqqnrt kqvegvtrrh vlsdleddev rdlgstgtss vqrqevkiee seasvegfse
      961 lenseetrte swelknqisq lqeqlmmlca dcdrasekkq dllfdvsvlk kklkmlerip
     1021 easpkyklly edvsrendcl qeelrmmetr ydealennke ltaevfrlqd elkkmeevte
     1081 tflsleksyd evkienegln vlvlrlqgki eklqesvvqr cdcclweasl enleiepdgn
     1141 ilqlnqtlee cvprvrsvhh vieeckqenq ylegntqlle kvkaheiawl hgtiqthqer
     1201 prvqnqvile enttllgfqd khfqhqatia elelektklq eltrklkerv tilvkqkdvl
     1261 shgekeeelk ammhdlqitc semqqkvell ryeseklqqe nsilrneitt lneedsisnl
     1321 klgtlngsqe emwqktetvk qenaavqkmv enlkkqisel kiknqqldle ntelsqknsq
     1381 nqeklqelnq rltemlcqke kepgnsalee reqekfnlke elerckvqss tlvssleael
     1441 sevkiqthiv qqenhllkde lekmkqlhrc pdlsdfqqki ssvlsynekl lkekealsee
     1501 lnscvdklak ssllehriat mkqeqksweh qsaslksqlv asqekvqnle dtvqnvnlqm
     1561 srmksdlrvt qqekealkqe vmslhkqlqn aggkswapei athpsglhnq qkrlswdkld
     1621 hlmneeqqll wqenerlqtm vqntkaelth srekvrqles nllpkhqkhl npsgtmnpte
     1681 qeklslkrec dqfqkeqspa nrkvsqmnsl eqeletihle neglkkkqvk ldeqlmemqh
     1741 lrstatpsps phawdlqllq qqacpmvpre qflqlqrqll qaerinqhlq eelenrtset
     1801 ntpqgnqeql vtvmeermie veqklklvkr llqekvnqlk eqlckntkad amvkdlyven
     1861 aqllkalevt eqrqktaekk nylleekias lsnivrnltp apltstpplr s
//
LOCUS       XP_047287395            1881 aa            linear   PRI 05-AUG-2025
DEFINITION  ninein isoform X11 [Homo sapiens].
ACCESSION   XP_047287395
VERSION     XP_047287395.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431439.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1881
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1881
                     /product="ninein isoform X11"
                     /calculated_mol_wt=218960
     Region          151..>770
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          444..1385
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          <1180..>1843
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1881
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /coded_by="XM_047431439.1:695..6340"
                     /db_xref="GeneID:51199"
                     /db_xref="HGNC:HGNC:14906"
                     /db_xref="MIM:608684"
ORIGIN      
        1 mleevfhnld pdgtmsvedf fyglfkngks ltpsastpyr qlkrhlsmqs fdesgrrttt
       61 ssamtstigf rvfsclddgm ghasverild twqeegiens qeilkaldfs ldgninltel
      121 tlalenellv tknsihqaal asfkaeirhl lervdqvvre keklrsdldk aeklkslmas
      181 evddhhaaie rrneynlrkl deeykeriaa lknelrkere qilqqagkqr leleqeieka
      241 kteenyirdr lalslkensr lenellenae klaeyenltn klqrnlenvl aekvlqdqvd
      301 elqseleeyr aqgrvlrlpl knspseevea nsggiepehg lgseecnpln msieaelvie
      361 qmkeqhhrdi cclrleledk vrhyekqlde tvvsckkaqe nmkqrhenet htlekqisdl
      421 kneiaelqgq aavlkeahhe atcrheeekk qlqvkleeek thlqeklrlq hemelkarlt
      481 qaqasferer eglqssawte ekvrgltqel eqfhqeqlts lvekhtleke elrkellekh
      541 qrelqegrek metecnrrts qieaqfqsdc qkvtercesa lqslegryrq elkdlqeqqr
      601 eeksqwefek deltqecaea qellketlkr ekttslvltq eremlektyk ehlnsmvver
      661 qqllqdledl rnvsetqqsl lsdqilelks shkrelrere evlcqagase qlasqrlerl
      721 emehdqerqe mmskllamen ihkatcetad reraemstei srlqskikem qqatsplsml
      781 qsgcqvigee evegdgalsl lqqgeqllee ngdvllslqr aheqavkenv kmateisrlq
      841 qrlqklepgl vmsscldepa teffgntaeq teqflqqnrt kqvegvtrrh vlsdleddev
      901 rdlgstgtss vqrqevkiee seasvegfse lenseetrte swelknqisq lqeqlmmlca
      961 dcdrasekkq dllfdvsvlk kklkmlerip easpkyklly edvsrendcl qeelrmmetr
     1021 ydealennke ltaevfrlqd elkkmeevte tflsleksyd evkienegln vlvlrlqgki
     1081 eklqesvvqr cdcclweasl enleiepdgn ilqlnqtlee cvprvrsvhh vieeckqenq
     1141 ylegntqlle kvkaheiawl hgtiqthqer prvqnqvile enttllgfqd khfqhqatia
     1201 elelektklq eltrklkerv tilvkqkdvl shgekeeelk ammhdlqitc semqqkvell
     1261 ryeseklqqe nsilrneitt lneedsisnl klgtlngsqe emwqktetvk qenaavqkmv
     1321 enlkkqisel kiknqqldle ntelsqknsq nqeklqelnq rltemlcqke kepgnsalee
     1381 reqekfnlke elerckvqss tlvssleael sevkiqthiv qqenhllkde lekmkqlhrc
     1441 pdlsdfqqki ssvlsynekl lkekealsee lnscvdklak ssllehriat mkqeqksweh
     1501 qsaslksqlv asqekvqnle dtvqnvnlqm srmksdlrvt qqekealkqe vmslhkqlqn
     1561 aggkswapei athpsglhnq qkrlswdkld hlmneeqqll wqenerlqtm vqntkaelth
     1621 srekvrqles nllpkhqkhl npsgtmnpte qeklslkrec dqfqkeqspa nrkvsqmnsl
     1681 eqeletihle neglkkkqvk ldeqlmemqh lrstatpsps phawdlqllq qqacpmvpre
     1741 qflqlqrqll qaerinqhlq eelenrtset ntpqgnqeql vtvmeermie veqklklvkr
     1801 llqekvnqlk eqlckntkad amvkdlyven aqllkalevt eqrqktaekk nylleekias
     1861 lsnivrnltp apltstpplr s
//
LOCUS       XP_011535124            1450 aa            linear   PRI 05-AUG-2025
DEFINITION  ninein isoform X12 [Homo sapiens].
ACCESSION   XP_011535124
VERSION     XP_011535124.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536822.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1450
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1450
                     /product="ninein isoform X12"
                     /calculated_mol_wt=168063
     Region          384..1196
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1450
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /coded_by="XM_011536822.3:233..4585"
                     /db_xref="GeneID:51199"
                     /db_xref="HGNC:HGNC:14906"
                     /db_xref="MIM:608684"
ORIGIN      
        1 mdeveqdqhe arlkelfdsf dttgtgslgq eeltdlchml sleevapvlq qtllqdnllg
       61 rvhfdqfkea lililsrtls neehfqepas vgvscqqvar vsgpllnghk lthcllikdc
      121 sleaqpkyvr ggkrygrrsl pefqesveef pevtviepld eearpshipa gdcsehwktq
      181 rseeyeaegq lrfwnpddln asqsgssppq dwieeklqev cedlgitrdg hlnrkklvsi
      241 ceqyglqnvd gemleevfhn ldpdgtmsve dffyglfkng ksltpsastp yrqlkrhlsm
      301 qsfdesgrrt ttssamtsti gfrvfscldd gmghasveri ldtwqeegie nsqeilkald
      361 fsldgninlt eltlalenel lvtknsihqa alasfkaeir hllervdqvv rekeklrsdl
      421 dkaeklkslm asevddhhaa ierrneynlr kldeeykeri aalknelrke reqilqqagk
      481 qrleleqeie kakteenyir drlalslken srlenellen aeklaeyenl tnklqrnlen
      541 vlaekfgdld pssaefflqe erltqmrney erqcrvlqdq vdelqselee yraqgrvlrl
      601 plknspseev eansggiepe hglgseecnp lnmsieaelv ieqmkeqhhr dicclrlele
      661 dkvrhyekql detvvsckka qenmkqrhen ethtlekqis dlkneiaelq gqaavlkeah
      721 heatcrheee kkqlqvklee ekthlqeklr lqhemelkar ltqaqasfer ereglqssaw
      781 teekvrgltq eleqfhqeql tslvekhtle keelrkelle khqrelqegr yeseklqqen
      841 silrneittl needsisnlk lgtlngsqee mwqktetvkq enaavqkmve nlkkqiselk
      901 iknqqldlen telsqknsqn qeklqelnqr ltemlcqkek epgnsaleer eqekfnlkee
      961 lerckvqsst lvssleaels evkiqthivq qenhllkdel ekmkqlhrcp dlsdfqqkis
     1021 svlsynekll kekealseel nscvdklaks sllehriatm kqeqkswehq saslksqlva
     1081 sqekvqnled tvqnvnlqms rmksdlrvtq qekealkqev mslhkqlqna ggkswapeia
     1141 thpsglhnqq krlswdkldh lmneeqqllw qenerlqtmv qntkaelths rekvrqlesn
     1201 llpkhqkhln psgtmnpteq eklslkrecd qfqkeqspan rkvsqmnsle qeletihlen
     1261 eglkkkqvkl deqlmemqhl rstatpspsp hawdlqllqq qacpmvpreq flqlqrqllq
     1321 aerinqhlqe elenrtsetn tpqgnqeqlv tvmeermiev eqklklvkrl lqekvnqlke
     1381 qlckntkada mvkdlyvena qllkalevte qrqktaekkn ylleekiasl snivrnltpa
     1441 pltstpplrs
//
LOCUS       XP_047287396            1420 aa            linear   PRI 05-AUG-2025
DEFINITION  ninein isoform X13 [Homo sapiens].
ACCESSION   XP_047287396
VERSION     XP_047287396.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431440.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1420
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1420
                     /product="ninein isoform X13"
                     /calculated_mol_wt=164951
     Region          354..1166
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1420
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /coded_by="XM_047431440.1:233..4495"
                     /db_xref="GeneID:51199"
                     /db_xref="HGNC:HGNC:14906"
                     /db_xref="MIM:608684"
ORIGIN      
        1 mdeveqdqhe arlkelfdsf dttgtgslgq eeltdlchml sleevapvlq qtllqdnllg
       61 rvhfdqfkea lililsrtls neehfqepdc sleaqpkyvr ggkrygrrsl pefqesveef
      121 pevtviepld eearpshipa gdcsehwktq rseeyeaegq lrfwnpddln asqsgssppq
      181 dwieeklqev cedlgitrdg hlnrkklvsi ceqyglqnvd gemleevfhn ldpdgtmsve
      241 dffyglfkng ksltpsastp yrqlkrhlsm qsfdesgrrt ttssamtsti gfrvfscldd
      301 gmghasveri ldtwqeegie nsqeilkald fsldgninlt eltlalenel lvtknsihqa
      361 alasfkaeir hllervdqvv rekeklrsdl dkaeklkslm asevddhhaa ierrneynlr
      421 kldeeykeri aalknelrke reqilqqagk qrleleqeie kakteenyir drlalslken
      481 srlenellen aeklaeyenl tnklqrnlen vlaekfgdld pssaefflqe erltqmrney
      541 erqcrvlqdq vdelqselee yraqgrvlrl plknspseev eansggiepe hglgseecnp
      601 lnmsieaelv ieqmkeqhhr dicclrlele dkvrhyekql detvvsckka qenmkqrhen
      661 ethtlekqis dlkneiaelq gqaavlkeah heatcrheee kkqlqvklee ekthlqeklr
      721 lqhemelkar ltqaqasfer ereglqssaw teekvrgltq eleqfhqeql tslvekhtle
      781 keelrkelle khqrelqegr yeseklqqen silrneittl needsisnlk lgtlngsqee
      841 mwqktetvkq enaavqkmve nlkkqiselk iknqqldlen telsqknsqn qeklqelnqr
      901 ltemlcqkek epgnsaleer eqekfnlkee lerckvqsst lvssleaels evkiqthivq
      961 qenhllkdel ekmkqlhrcp dlsdfqqkis svlsynekll kekealseel nscvdklaks
     1021 sllehriatm kqeqkswehq saslksqlva sqekvqnled tvqnvnlqms rmksdlrvtq
     1081 qekealkqev mslhkqlqna ggkswapeia thpsglhnqq krlswdkldh lmneeqqllw
     1141 qenerlqtmv qntkaelths rekvrqlesn llpkhqkhln psgtmnpteq eklslkrecd
     1201 qfqkeqspan rkvsqmnsle qeletihlen eglkkkqvkl deqlmemqhl rstatpspsp
     1261 hawdlqllqq qacpmvpreq flqlqrqllq aerinqhlqe elenrtsetn tpqgnqeqlv
     1321 tvmeermiev eqklklvkrl lqekvnqlke qlckntkada mvkdlyvena qllkalevte
     1381 qrqktaekkn ylleekiasl snivrnltpa pltstpplrs
//
LOCUS       XP_047287397            1420 aa            linear   PRI 05-AUG-2025
DEFINITION  ninein isoform X14 [Homo sapiens].
ACCESSION   XP_047287397
VERSION     XP_047287397.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431441.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1420
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1420
                     /product="ninein isoform X14"
                     /calculated_mol_wt=164385
     Region          403..1166
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1420
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /coded_by="XM_047431441.1:233..4495"
                     /db_xref="GeneID:51199"
                     /db_xref="HGNC:HGNC:14906"
                     /db_xref="MIM:608684"
ORIGIN      
        1 mdeveqdqhe arlkelfdsf dttgtgslgq eeltdlchml sleevapvlq qtllqdnllg
       61 rvhfdqfkea lililsrtls neehfqepas vgvscqqvar vsgpllnghk lthcllikdc
      121 sleaqpkyvr ggkrygrrsl pefqesveef pevtviepld eearpshipa gdcsehwktq
      181 rseeyeaegq lrfwnpddln asqsgssppq dwieeklqev cedlgitrdg hlnrkklvsi
      241 ceqyglqnvd gemleevfhn ldpdgtmsve dffyglfkng ksltpsastp yrqlkrhlsm
      301 qsfdesgrrt ttssamtsti gfrvfscldd gmghasveri ldtwqeegie nsqeilkald
      361 fsldgninlt eltlalenel lvtknsihqa alasfkaeir hllervdqvv rekeklrsdl
      421 dkaeklkslm asevddhhaa ierrneynlr kldeeykeri aalknelrke reqilqqagk
      481 qrleleqeie kakteenyir drlalslken srlenellen aeklaeyenl tnklqrnlen
      541 vlaekvlqdq vdelqselee yraqgrvlrl plknspseev eansggiepe hglgseecnp
      601 lnmsieaelv ieqmkeqhhr dicclrlele dkvrhyekql detvvsckka qenmkqrhen
      661 ethtlekqis dlkneiaelq gqaavlkeah heatcrheee kkqlqvklee ekthlqeklr
      721 lqhemelkar ltqaqasfer ereglqssaw teekvrgltq eleqfhqeql tslvekhtle
      781 keelrkelle khqrelqegr yeseklqqen silrneittl needsisnlk lgtlngsqee
      841 mwqktetvkq enaavqkmve nlkkqiselk iknqqldlen telsqknsqn qeklqelnqr
      901 ltemlcqkek epgnsaleer eqekfnlkee lerckvqsst lvssleaels evkiqthivq
      961 qenhllkdel ekmkqlhrcp dlsdfqqkis svlsynekll kekealseel nscvdklaks
     1021 sllehriatm kqeqkswehq saslksqlva sqekvqnled tvqnvnlqms rmksdlrvtq
     1081 qekealkqev mslhkqlqna ggkswapeia thpsglhnqq krlswdkldh lmneeqqllw
     1141 qenerlqtmv qntkaelths rekvrqlesn llpkhqkhln psgtmnpteq eklslkrecd
     1201 qfqkeqspan rkvsqmnsle qeletihlen eglkkkqvkl deqlmemqhl rstatpspsp
     1261 hawdlqllqq qacpmvpreq flqlqrqllq aerinqhlqe elenrtsetn tpqgnqeqlv
     1321 tvmeermiev eqklklvkrl lqekvnqlke qlckntkada mvkdlyvena qllkalevte
     1381 qrqktaekkn ylleekiasl snivrnltpa pltstpplrs
//
LOCUS       XP_047287398            1390 aa            linear   PRI 05-AUG-2025
DEFINITION  ninein isoform X15 [Homo sapiens].
ACCESSION   XP_047287398
VERSION     XP_047287398.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431442.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1390
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1390
                     /product="ninein isoform X15"
                     /calculated_mol_wt=161273
     Region          373..1136
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1390
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /coded_by="XM_047431442.1:233..4405"
                     /db_xref="GeneID:51199"
                     /db_xref="HGNC:HGNC:14906"
                     /db_xref="MIM:608684"
ORIGIN      
        1 mdeveqdqhe arlkelfdsf dttgtgslgq eeltdlchml sleevapvlq qtllqdnllg
       61 rvhfdqfkea lililsrtls neehfqepdc sleaqpkyvr ggkrygrrsl pefqesveef
      121 pevtviepld eearpshipa gdcsehwktq rseeyeaegq lrfwnpddln asqsgssppq
      181 dwieeklqev cedlgitrdg hlnrkklvsi ceqyglqnvd gemleevfhn ldpdgtmsve
      241 dffyglfkng ksltpsastp yrqlkrhlsm qsfdesgrrt ttssamtsti gfrvfscldd
      301 gmghasveri ldtwqeegie nsqeilkald fsldgninlt eltlalenel lvtknsihqa
      361 alasfkaeir hllervdqvv rekeklrsdl dkaeklkslm asevddhhaa ierrneynlr
      421 kldeeykeri aalknelrke reqilqqagk qrleleqeie kakteenyir drlalslken
      481 srlenellen aeklaeyenl tnklqrnlen vlaekvlqdq vdelqselee yraqgrvlrl
      541 plknspseev eansggiepe hglgseecnp lnmsieaelv ieqmkeqhhr dicclrlele
      601 dkvrhyekql detvvsckka qenmkqrhen ethtlekqis dlkneiaelq gqaavlkeah
      661 heatcrheee kkqlqvklee ekthlqeklr lqhemelkar ltqaqasfer ereglqssaw
      721 teekvrgltq eleqfhqeql tslvekhtle keelrkelle khqrelqegr yeseklqqen
      781 silrneittl needsisnlk lgtlngsqee mwqktetvkq enaavqkmve nlkkqiselk
      841 iknqqldlen telsqknsqn qeklqelnqr ltemlcqkek epgnsaleer eqekfnlkee
      901 lerckvqsst lvssleaels evkiqthivq qenhllkdel ekmkqlhrcp dlsdfqqkis
      961 svlsynekll kekealseel nscvdklaks sllehriatm kqeqkswehq saslksqlva
     1021 sqekvqnled tvqnvnlqms rmksdlrvtq qekealkqev mslhkqlqna ggkswapeia
     1081 thpsglhnqq krlswdkldh lmneeqqllw qenerlqtmv qntkaelths rekvrqlesn
     1141 llpkhqkhln psgtmnpteq eklslkrecd qfqkeqspan rkvsqmnsle qeletihlen
     1201 eglkkkqvkl deqlmemqhl rstatpspsp hawdlqllqq qacpmvpreq flqlqrqllq
     1261 aerinqhlqe elenrtsetn tpqgnqeqlv tvmeermiev eqklklvkrl lqekvnqlke
     1321 qlckntkada mvkdlyvena qllkalevte qrqktaekkn ylleekiasl snivrnltpa
     1381 pltstpplrs
//
LOCUS       XP_047287399            1378 aa            linear   PRI 05-AUG-2025
DEFINITION  ninein isoform X16 [Homo sapiens].
ACCESSION   XP_047287399
VERSION     XP_047287399.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431443.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1378
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1378
                     /product="ninein isoform X16"
                     /calculated_mol_wt=159478
     Region          <437..838
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          645..>1340
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1378
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /coded_by="XM_047431443.1:233..4369"
                     /db_xref="GeneID:51199"
                     /db_xref="HGNC:HGNC:14906"
                     /db_xref="MIM:608684"
ORIGIN      
        1 mdeveqdqhe arlkelfdsf dttgtgslgq eeltdlchml sleevapvlq qtllqdnllg
       61 rvhfdqfkea lililsrtls neehfqepas vgvscqqvar vsgpllnghk lthcllikdc
      121 sleaqpkyvr ggkrygrrsl pefqesveef pevtviepld eearpshipa gdcsehwktq
      181 rseeyeaegq lrfwnpddln asqsgssppq dwieeklqev cedlgitrdg hlnrkklvsi
      241 ceqyglqnvd gemleevfhn ldpdgtmsve dffyglfkng ksltpsastp yrqlkrhlsm
      301 qsfdesgrrt ttssamtsti gfrvfscldd gmghasveri ldtwqeegie nsqeilkald
      361 fsldgninlt eltlalenel lvtknsihqa alasfkaeir hllervdqvv rekeklrsdl
      421 dkaeklkslm asevddhhaa ierrneynlr kldeeykeri aalknelrke reqilqqagk
      481 qrleleqeie kakteenyir drlalslken srlenellen aeklaeyenl tnklqrnlen
      541 vlaekfgdld pssaefflqe erltqmrney erqcrvlqdq vdelqselee yraqgrvlrl
      601 plknspseev eansggiepe hglgseecnp lnmsieaelv ieqmkeqhhr dicclrlele
      661 dkvrhyekql detvvsckka qenmkqrhen ethtlekqis dlkneiaelq gqaavlkeah
      721 heatcrheee kkqlqvklee ekthlqeklr lqhemelkar ltqaqasfer ereglqssaw
      781 teekvrgltq eleqfhqeql tslvekhtle keelrkelle khqrelqegr yeseklqqen
      841 silrneittl needsisnlk lgtlngsqee mwqktetvkq enaavqkmve nlkkqsstlv
      901 ssleaelsev kiqthivqqe nhllkdelek mkqlhrcpdl sdfqqkissv lsynekllke
      961 kealseelns cvdklakssl lehriatmkq eqkswehqsa slksqlvasq ekvqnledtv
     1021 qnvnlqmsrm ksdlrvtqqe kealkqevms lhkqlqnagg kswapeiath psglhnqqkr
     1081 lswdkldhlm neeqqllwqe nerlqtmvqn tkaelthsre kvrqlesnll pkhqkhlnps
     1141 gtmnpteqek lslkrecdqf qkeqspanrk vsqmnsleqe letihleneg lkkkqvklde
     1201 qlmemqhlrs tatpspspha wdlqllqqqa cpmvpreqfl qlqrqllqae rinqhlqeel
     1261 enrtsetntp qgnqeqlvtv meermieveq klklvkrllq ekvnqlkeql ckntkadamv
     1321 kdlyvenaql lkalevteqr qktaekknyl leekiaslsn ivrnltpapl tstpplrs
//
LOCUS       XP_047287400            1363 aa            linear   PRI 05-AUG-2025
DEFINITION  ninein isoform X17 [Homo sapiens].
ACCESSION   XP_047287400
VERSION     XP_047287400.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431444.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1363
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1363
                     /product="ninein isoform X17"
                     /calculated_mol_wt=158062
     Region          384..1196
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1363
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /coded_by="XM_047431444.1:233..4324"
                     /db_xref="GeneID:51199"
                     /db_xref="HGNC:HGNC:14906"
                     /db_xref="MIM:608684"
ORIGIN      
        1 mdeveqdqhe arlkelfdsf dttgtgslgq eeltdlchml sleevapvlq qtllqdnllg
       61 rvhfdqfkea lililsrtls neehfqepas vgvscqqvar vsgpllnghk lthcllikdc
      121 sleaqpkyvr ggkrygrrsl pefqesveef pevtviepld eearpshipa gdcsehwktq
      181 rseeyeaegq lrfwnpddln asqsgssppq dwieeklqev cedlgitrdg hlnrkklvsi
      241 ceqyglqnvd gemleevfhn ldpdgtmsve dffyglfkng ksltpsastp yrqlkrhlsm
      301 qsfdesgrrt ttssamtsti gfrvfscldd gmghasveri ldtwqeegie nsqeilkald
      361 fsldgninlt eltlalenel lvtknsihqa alasfkaeir hllervdqvv rekeklrsdl
      421 dkaeklkslm asevddhhaa ierrneynlr kldeeykeri aalknelrke reqilqqagk
      481 qrleleqeie kakteenyir drlalslken srlenellen aeklaeyenl tnklqrnlen
      541 vlaekfgdld pssaefflqe erltqmrney erqcrvlqdq vdelqselee yraqgrvlrl
      601 plknspseev eansggiepe hglgseecnp lnmsieaelv ieqmkeqhhr dicclrlele
      661 dkvrhyekql detvvsckka qenmkqrhen ethtlekqis dlkneiaelq gqaavlkeah
      721 heatcrheee kkqlqvklee ekthlqeklr lqhemelkar ltqaqasfer ereglqssaw
      781 teekvrgltq eleqfhqeql tslvekhtle keelrkelle khqrelqegr yeseklqqen
      841 silrneittl needsisnlk lgtlngsqee mwqktetvkq enaavqkmve nlkkqiselk
      901 iknqqldlen telsqknsqn qeklqelnqr ltemlcqkek epgnsaleer eqekfnlkee
      961 lerckvqsst lvssleaels evkiqthivq qenhllkdel ekmkqlhrcp dlsdfqqkis
     1021 svlsynekll kekealseel nscvdklaks sllehriatm kqeqkswehq saslksqlva
     1081 sqekvqnled tvqnvnlqms rmksdlrvtq qekealkqev mslhkqlqna ggkswapeia
     1141 thpsglhnqq krlswdkldh lmneeqqllw qenerlqtmv qntkaelths rekvrqlesn
     1201 llpkhqkhln psgtmnpteq eklslkrecd qfqkeqspan rkvsqmnsle qeletihlen
     1261 eglkkkqvkl deqlmemqhl rstatpspsp hawdlqllqq qacpmvpreq flqlqrqllq
     1321 aerinqhlqe elenrtsetn tpqallpeqr avhadsyrri ghl
//
LOCUS       XP_047287401            1348 aa            linear   PRI 05-AUG-2025
DEFINITION  ninein isoform X18 [Homo sapiens].
ACCESSION   XP_047287401
VERSION     XP_047287401.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431445.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1348
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1348
                     /product="ninein isoform X18"
                     /calculated_mol_wt=156366
     Region          <407..808
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          615..>1310
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1348
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /coded_by="XM_047431445.1:233..4279"
                     /db_xref="GeneID:51199"
                     /db_xref="HGNC:HGNC:14906"
                     /db_xref="MIM:608684"
ORIGIN      
        1 mdeveqdqhe arlkelfdsf dttgtgslgq eeltdlchml sleevapvlq qtllqdnllg
       61 rvhfdqfkea lililsrtls neehfqepdc sleaqpkyvr ggkrygrrsl pefqesveef
      121 pevtviepld eearpshipa gdcsehwktq rseeyeaegq lrfwnpddln asqsgssppq
      181 dwieeklqev cedlgitrdg hlnrkklvsi ceqyglqnvd gemleevfhn ldpdgtmsve
      241 dffyglfkng ksltpsastp yrqlkrhlsm qsfdesgrrt ttssamtsti gfrvfscldd
      301 gmghasveri ldtwqeegie nsqeilkald fsldgninlt eltlalenel lvtknsihqa
      361 alasfkaeir hllervdqvv rekeklrsdl dkaeklkslm asevddhhaa ierrneynlr
      421 kldeeykeri aalknelrke reqilqqagk qrleleqeie kakteenyir drlalslken
      481 srlenellen aeklaeyenl tnklqrnlen vlaekfgdld pssaefflqe erltqmrney
      541 erqcrvlqdq vdelqselee yraqgrvlrl plknspseev eansggiepe hglgseecnp
      601 lnmsieaelv ieqmkeqhhr dicclrlele dkvrhyekql detvvsckka qenmkqrhen
      661 ethtlekqis dlkneiaelq gqaavlkeah heatcrheee kkqlqvklee ekthlqeklr
      721 lqhemelkar ltqaqasfer ereglqssaw teekvrgltq eleqfhqeql tslvekhtle
      781 keelrkelle khqrelqegr yeseklqqen silrneittl needsisnlk lgtlngsqee
      841 mwqktetvkq enaavqkmve nlkkqsstlv ssleaelsev kiqthivqqe nhllkdelek
      901 mkqlhrcpdl sdfqqkissv lsynekllke kealseelns cvdklakssl lehriatmkq
      961 eqkswehqsa slksqlvasq ekvqnledtv qnvnlqmsrm ksdlrvtqqe kealkqevms
     1021 lhkqlqnagg kswapeiath psglhnqqkr lswdkldhlm neeqqllwqe nerlqtmvqn
     1081 tkaelthsre kvrqlesnll pkhqkhlnps gtmnpteqek lslkrecdqf qkeqspanrk
     1141 vsqmnsleqe letihleneg lkkkqvklde qlmemqhlrs tatpspspha wdlqllqqqa
     1201 cpmvpreqfl qlqrqllqae rinqhlqeel enrtsetntp qgnqeqlvtv meermieveq
     1261 klklvkrllq ekvnqlkeql ckntkadamv kdlyvenaql lkalevteqr qktaekknyl
     1321 leekiaslsn ivrnltpapl tstpplrs
//
LOCUS       XP_047287402            1333 aa            linear   PRI 05-AUG-2025
DEFINITION  ninein isoform X19 [Homo sapiens].
ACCESSION   XP_047287402
VERSION     XP_047287402.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431446.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1333
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1333
                     /product="ninein isoform X19"
                     /calculated_mol_wt=154950
     Region          354..1166
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1333
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /coded_by="XM_047431446.1:233..4234"
                     /db_xref="GeneID:51199"
                     /db_xref="HGNC:HGNC:14906"
                     /db_xref="MIM:608684"
ORIGIN      
        1 mdeveqdqhe arlkelfdsf dttgtgslgq eeltdlchml sleevapvlq qtllqdnllg
       61 rvhfdqfkea lililsrtls neehfqepdc sleaqpkyvr ggkrygrrsl pefqesveef
      121 pevtviepld eearpshipa gdcsehwktq rseeyeaegq lrfwnpddln asqsgssppq
      181 dwieeklqev cedlgitrdg hlnrkklvsi ceqyglqnvd gemleevfhn ldpdgtmsve
      241 dffyglfkng ksltpsastp yrqlkrhlsm qsfdesgrrt ttssamtsti gfrvfscldd
      301 gmghasveri ldtwqeegie nsqeilkald fsldgninlt eltlalenel lvtknsihqa
      361 alasfkaeir hllervdqvv rekeklrsdl dkaeklkslm asevddhhaa ierrneynlr
      421 kldeeykeri aalknelrke reqilqqagk qrleleqeie kakteenyir drlalslken
      481 srlenellen aeklaeyenl tnklqrnlen vlaekfgdld pssaefflqe erltqmrney
      541 erqcrvlqdq vdelqselee yraqgrvlrl plknspseev eansggiepe hglgseecnp
      601 lnmsieaelv ieqmkeqhhr dicclrlele dkvrhyekql detvvsckka qenmkqrhen
      661 ethtlekqis dlkneiaelq gqaavlkeah heatcrheee kkqlqvklee ekthlqeklr
      721 lqhemelkar ltqaqasfer ereglqssaw teekvrgltq eleqfhqeql tslvekhtle
      781 keelrkelle khqrelqegr yeseklqqen silrneittl needsisnlk lgtlngsqee
      841 mwqktetvkq enaavqkmve nlkkqiselk iknqqldlen telsqknsqn qeklqelnqr
      901 ltemlcqkek epgnsaleer eqekfnlkee lerckvqsst lvssleaels evkiqthivq
      961 qenhllkdel ekmkqlhrcp dlsdfqqkis svlsynekll kekealseel nscvdklaks
     1021 sllehriatm kqeqkswehq saslksqlva sqekvqnled tvqnvnlqms rmksdlrvtq
     1081 qekealkqev mslhkqlqna ggkswapeia thpsglhnqq krlswdkldh lmneeqqllw
     1141 qenerlqtmv qntkaelths rekvrqlesn llpkhqkhln psgtmnpteq eklslkrecd
     1201 qfqkeqspan rkvsqmnsle qeletihlen eglkkkqvkl deqlmemqhl rstatpspsp
     1261 hawdlqllqq qacpmvpreq flqlqrqllq aerinqhlqe elenrtsetn tpqallpeqr
     1321 avhadsyrri ghl
//
LOCUS       XP_047287403            1333 aa            linear   PRI 05-AUG-2025
DEFINITION  ninein isoform X20 [Homo sapiens].
ACCESSION   XP_047287403
VERSION     XP_047287403.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431447.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1333
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1333
                     /product="ninein isoform X20"
                     /calculated_mol_wt=154384
     Region          403..1166
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1333
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /coded_by="XM_047431447.1:233..4234"
                     /db_xref="GeneID:51199"
                     /db_xref="HGNC:HGNC:14906"
                     /db_xref="MIM:608684"
ORIGIN      
        1 mdeveqdqhe arlkelfdsf dttgtgslgq eeltdlchml sleevapvlq qtllqdnllg
       61 rvhfdqfkea lililsrtls neehfqepas vgvscqqvar vsgpllnghk lthcllikdc
      121 sleaqpkyvr ggkrygrrsl pefqesveef pevtviepld eearpshipa gdcsehwktq
      181 rseeyeaegq lrfwnpddln asqsgssppq dwieeklqev cedlgitrdg hlnrkklvsi
      241 ceqyglqnvd gemleevfhn ldpdgtmsve dffyglfkng ksltpsastp yrqlkrhlsm
      301 qsfdesgrrt ttssamtsti gfrvfscldd gmghasveri ldtwqeegie nsqeilkald
      361 fsldgninlt eltlalenel lvtknsihqa alasfkaeir hllervdqvv rekeklrsdl
      421 dkaeklkslm asevddhhaa ierrneynlr kldeeykeri aalknelrke reqilqqagk
      481 qrleleqeie kakteenyir drlalslken srlenellen aeklaeyenl tnklqrnlen
      541 vlaekvlqdq vdelqselee yraqgrvlrl plknspseev eansggiepe hglgseecnp
      601 lnmsieaelv ieqmkeqhhr dicclrlele dkvrhyekql detvvsckka qenmkqrhen
      661 ethtlekqis dlkneiaelq gqaavlkeah heatcrheee kkqlqvklee ekthlqeklr
      721 lqhemelkar ltqaqasfer ereglqssaw teekvrgltq eleqfhqeql tslvekhtle
      781 keelrkelle khqrelqegr yeseklqqen silrneittl needsisnlk lgtlngsqee
      841 mwqktetvkq enaavqkmve nlkkqiselk iknqqldlen telsqknsqn qeklqelnqr
      901 ltemlcqkek epgnsaleer eqekfnlkee lerckvqsst lvssleaels evkiqthivq
      961 qenhllkdel ekmkqlhrcp dlsdfqqkis svlsynekll kekealseel nscvdklaks
     1021 sllehriatm kqeqkswehq saslksqlva sqekvqnled tvqnvnlqms rmksdlrvtq
     1081 qekealkqev mslhkqlqna ggkswapeia thpsglhnqq krlswdkldh lmneeqqllw
     1141 qenerlqtmv qntkaelths rekvrqlesn llpkhqkhln psgtmnpteq eklslkrecd
     1201 qfqkeqspan rkvsqmnsle qeletihlen eglkkkqvkl deqlmemqhl rstatpspsp
     1261 hawdlqllqq qacpmvpreq flqlqrqllq aerinqhlqe elenrtsetn tpqallpeqr
     1321 avhadsyrri ghl
//
LOCUS       XP_047287404            1306 aa            linear   PRI 05-AUG-2025
DEFINITION  ninein isoform X21 [Homo sapiens].
ACCESSION   XP_047287404
VERSION     XP_047287404.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431448.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1306
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1306
                     /product="ninein isoform X21"
                     /calculated_mol_wt=150967
     Region          384..1196
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1306
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /coded_by="XM_047431448.1:233..4153"
                     /db_xref="GeneID:51199"
                     /db_xref="HGNC:HGNC:14906"
                     /db_xref="MIM:608684"
ORIGIN      
        1 mdeveqdqhe arlkelfdsf dttgtgslgq eeltdlchml sleevapvlq qtllqdnllg
       61 rvhfdqfkea lililsrtls neehfqepas vgvscqqvar vsgpllnghk lthcllikdc
      121 sleaqpkyvr ggkrygrrsl pefqesveef pevtviepld eearpshipa gdcsehwktq
      181 rseeyeaegq lrfwnpddln asqsgssppq dwieeklqev cedlgitrdg hlnrkklvsi
      241 ceqyglqnvd gemleevfhn ldpdgtmsve dffyglfkng ksltpsastp yrqlkrhlsm
      301 qsfdesgrrt ttssamtsti gfrvfscldd gmghasveri ldtwqeegie nsqeilkald
      361 fsldgninlt eltlalenel lvtknsihqa alasfkaeir hllervdqvv rekeklrsdl
      421 dkaeklkslm asevddhhaa ierrneynlr kldeeykeri aalknelrke reqilqqagk
      481 qrleleqeie kakteenyir drlalslken srlenellen aeklaeyenl tnklqrnlen
      541 vlaekfgdld pssaefflqe erltqmrney erqcrvlqdq vdelqselee yraqgrvlrl
      601 plknspseev eansggiepe hglgseecnp lnmsieaelv ieqmkeqhhr dicclrlele
      661 dkvrhyekql detvvsckka qenmkqrhen ethtlekqis dlkneiaelq gqaavlkeah
      721 heatcrheee kkqlqvklee ekthlqeklr lqhemelkar ltqaqasfer ereglqssaw
      781 teekvrgltq eleqfhqeql tslvekhtle keelrkelle khqrelqegr yeseklqqen
      841 silrneittl needsisnlk lgtlngsqee mwqktetvkq enaavqkmve nlkkqiselk
      901 iknqqldlen telsqknsqn qeklqelnqr ltemlcqkek epgnsaleer eqekfnlkee
      961 lerckvqsst lvssleaels evkiqthivq qenhllkdel ekmkqlhrcp dlsdfqqkis
     1021 svlsynekll kekealseel nscvdklaks sllehriatm kqeqkswehq saslksqlva
     1081 sqekvqnled tvqnvnlqms rmksdlrvtq qekealkqev mslhkqlqna ggkswapeia
     1141 thpsglhnqq krlswdkldh lmneeqqllw qenerlqtmv qntkaelths rekvrqlesn
     1201 llpkhqkhln psgtmnpteq eklslkrecd qfqkeqspan rkvsqmnsle qeletihlen
     1261 eglkkkqvkl deqlmensvv gssregcssl peivcedaap evhcda
//
LOCUS       XP_047287405            1303 aa            linear   PRI 05-AUG-2025
DEFINITION  ninein isoform X22 [Homo sapiens].
ACCESSION   XP_047287405
VERSION     XP_047287405.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431449.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1303
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1303
                     /product="ninein isoform X22"
                     /calculated_mol_wt=151272
     Region          373..1136
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1303
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /coded_by="XM_047431449.1:233..4144"
                     /db_xref="GeneID:51199"
                     /db_xref="HGNC:HGNC:14906"
                     /db_xref="MIM:608684"
ORIGIN      
        1 mdeveqdqhe arlkelfdsf dttgtgslgq eeltdlchml sleevapvlq qtllqdnllg
       61 rvhfdqfkea lililsrtls neehfqepdc sleaqpkyvr ggkrygrrsl pefqesveef
      121 pevtviepld eearpshipa gdcsehwktq rseeyeaegq lrfwnpddln asqsgssppq
      181 dwieeklqev cedlgitrdg hlnrkklvsi ceqyglqnvd gemleevfhn ldpdgtmsve
      241 dffyglfkng ksltpsastp yrqlkrhlsm qsfdesgrrt ttssamtsti gfrvfscldd
      301 gmghasveri ldtwqeegie nsqeilkald fsldgninlt eltlalenel lvtknsihqa
      361 alasfkaeir hllervdqvv rekeklrsdl dkaeklkslm asevddhhaa ierrneynlr
      421 kldeeykeri aalknelrke reqilqqagk qrleleqeie kakteenyir drlalslken
      481 srlenellen aeklaeyenl tnklqrnlen vlaekvlqdq vdelqselee yraqgrvlrl
      541 plknspseev eansggiepe hglgseecnp lnmsieaelv ieqmkeqhhr dicclrlele
      601 dkvrhyekql detvvsckka qenmkqrhen ethtlekqis dlkneiaelq gqaavlkeah
      661 heatcrheee kkqlqvklee ekthlqeklr lqhemelkar ltqaqasfer ereglqssaw
      721 teekvrgltq eleqfhqeql tslvekhtle keelrkelle khqrelqegr yeseklqqen
      781 silrneittl needsisnlk lgtlngsqee mwqktetvkq enaavqkmve nlkkqiselk
      841 iknqqldlen telsqknsqn qeklqelnqr ltemlcqkek epgnsaleer eqekfnlkee
      901 lerckvqsst lvssleaels evkiqthivq qenhllkdel ekmkqlhrcp dlsdfqqkis
      961 svlsynekll kekealseel nscvdklaks sllehriatm kqeqkswehq saslksqlva
     1021 sqekvqnled tvqnvnlqms rmksdlrvtq qekealkqev mslhkqlqna ggkswapeia
     1081 thpsglhnqq krlswdkldh lmneeqqllw qenerlqtmv qntkaelths rekvrqlesn
     1141 llpkhqkhln psgtmnpteq eklslkrecd qfqkeqspan rkvsqmnsle qeletihlen
     1201 eglkkkqvkl deqlmemqhl rstatpspsp hawdlqllqq qacpmvpreq flqlqrqllq
     1261 aerinqhlqe elenrtsetn tpqallpeqr avhadsyrri ghl
//
LOCUS       XP_047287406            1198 aa            linear   PRI 05-AUG-2025
DEFINITION  ninein isoform X23 [Homo sapiens].
ACCESSION   XP_047287406
VERSION     XP_047287406.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431450.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1198
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1198
                     /product="ninein isoform X23"
                     /calculated_mol_wt=139525
     Region          132..944
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1198
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /coded_by="XM_047431450.1:785..4381"
                     /db_xref="GeneID:51199"
                     /db_xref="HGNC:HGNC:14906"
                     /db_xref="MIM:608684"
ORIGIN      
        1 mleevfhnld pdgtmsvedf fyglfkngks ltpsastpyr qlkrhlsmqs fdesgrrttt
       61 ssamtstigf rvfsclddgm ghasverild twqeegiens qeilkaldfs ldgninltel
      121 tlalenellv tknsihqaal asfkaeirhl lervdqvvre keklrsdldk aeklkslmas
      181 evddhhaaie rrneynlrkl deeykeriaa lknelrkere qilqqagkqr leleqeieka
      241 kteenyirdr lalslkensr lenellenae klaeyenltn klqrnlenvl aekfgdldps
      301 saefflqeer ltqmrneyer qcrvlqdqvd elqseleeyr aqgrvlrlpl knspseevea
      361 nsggiepehg lgseecnpln msieaelvie qmkeqhhrdi cclrleledk vrhyekqlde
      421 tvvsckkaqe nmkqrhenet htlekqisdl kneiaelqgq aavlkeahhe atcrheeekk
      481 qlqvkleeek thlqeklrlq hemelkarlt qaqasferer eglqssawte ekvrgltqel
      541 eqfhqeqlts lvekhtleke elrkellekh qrelqegrye seklqqensi lrneittlne
      601 edsisnlklg tlngsqeemw qktetvkqen aavqkmvenl kkqiselkik nqqldlente
      661 lsqknsqnqe klqelnqrlt emlcqkekep gnsaleereq ekfnlkeele rckvqsstlv
      721 ssleaelsev kiqthivqqe nhllkdelek mkqlhrcpdl sdfqqkissv lsynekllke
      781 kealseelns cvdklakssl lehriatmkq eqkswehqsa slksqlvasq ekvqnledtv
      841 qnvnlqmsrm ksdlrvtqqe kealkqevms lhkqlqnagg kswapeiath psglhnqqkr
      901 lswdkldhlm neeqqllwqe nerlqtmvqn tkaelthsre kvrqlesnll pkhqkhlnps
      961 gtmnpteqek lslkrecdqf qkeqspanrk vsqmnsleqe letihleneg lkkkqvklde
     1021 qlmemqhlrs tatpspspha wdlqllqqqa cpmvpreqfl qlqrqllqae rinqhlqeel
     1081 enrtsetntp qgnqeqlvtv meermieveq klklvkrllq ekvnqlkeql ckntkadamv
     1141 kdlyvenaql lkalevteqr qktaekknyl leekiaslsn ivrnltpapl tstpplrs
//
LOCUS       XP_047287407            1261 aa            linear   PRI 05-AUG-2025
DEFINITION  ninein isoform X24 [Homo sapiens].
ACCESSION   XP_047287407
VERSION     XP_047287407.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431451.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1261
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1261
                     /product="ninein isoform X24"
                     /calculated_mol_wt=146365
     Region          <407..808
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          486..>1176
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     CDS             1..1261
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /coded_by="XM_047431451.1:233..4018"
                     /db_xref="GeneID:51199"
                     /db_xref="HGNC:HGNC:14906"
                     /db_xref="MIM:608684"
ORIGIN      
        1 mdeveqdqhe arlkelfdsf dttgtgslgq eeltdlchml sleevapvlq qtllqdnllg
       61 rvhfdqfkea lililsrtls neehfqepdc sleaqpkyvr ggkrygrrsl pefqesveef
      121 pevtviepld eearpshipa gdcsehwktq rseeyeaegq lrfwnpddln asqsgssppq
      181 dwieeklqev cedlgitrdg hlnrkklvsi ceqyglqnvd gemleevfhn ldpdgtmsve
      241 dffyglfkng ksltpsastp yrqlkrhlsm qsfdesgrrt ttssamtsti gfrvfscldd
      301 gmghasveri ldtwqeegie nsqeilkald fsldgninlt eltlalenel lvtknsihqa
      361 alasfkaeir hllervdqvv rekeklrsdl dkaeklkslm asevddhhaa ierrneynlr
      421 kldeeykeri aalknelrke reqilqqagk qrleleqeie kakteenyir drlalslken
      481 srlenellen aeklaeyenl tnklqrnlen vlaekfgdld pssaefflqe erltqmrney
      541 erqcrvlqdq vdelqselee yraqgrvlrl plknspseev eansggiepe hglgseecnp
      601 lnmsieaelv ieqmkeqhhr dicclrlele dkvrhyekql detvvsckka qenmkqrhen
      661 ethtlekqis dlkneiaelq gqaavlkeah heatcrheee kkqlqvklee ekthlqeklr
      721 lqhemelkar ltqaqasfer ereglqssaw teekvrgltq eleqfhqeql tslvekhtle
      781 keelrkelle khqrelqegr yeseklqqen silrneittl needsisnlk lgtlngsqee
      841 mwqktetvkq enaavqkmve nlkkqsstlv ssleaelsev kiqthivqqe nhllkdelek
      901 mkqlhrcpdl sdfqqkissv lsynekllke kealseelns cvdklakssl lehriatmkq
      961 eqkswehqsa slksqlvasq ekvqnledtv qnvnlqmsrm ksdlrvtqqe kealkqevms
     1021 lhkqlqnagg kswapeiath psglhnqqkr lswdkldhlm neeqqllwqe nerlqtmvqn
     1081 tkaelthsre kvrqlesnll pkhqkhlnps gtmnpteqek lslkrecdqf qkeqspanrk
     1141 vsqmnsleqe letihleneg lkkkqvklde qlmemqhlrs tatpspspha wdlqllqqqa
     1201 cpmvpreqfl qlqrqllqae rinqhlqeel enrtsetntp qallpeqrav hadsyrrigh
     1261 l
//
LOCUS       XP_047287408            1168 aa            linear   PRI 05-AUG-2025
DEFINITION  ninein isoform X25 [Homo sapiens].
ACCESSION   XP_047287408
VERSION     XP_047287408.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431452.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1168
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1168
                     /product="ninein isoform X25"
                     /calculated_mol_wt=135847
     Region          <138..689
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          419..>1130
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1168
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /coded_by="XM_047431452.1:584..4090"
                     /db_xref="GeneID:51199"
                     /db_xref="HGNC:HGNC:14906"
                     /db_xref="MIM:608684"
ORIGIN      
        1 mleevfhnld pdgtmsvedf fyglfkngks ltpsastpyr qlkrhlsmqs fdesgrrttt
       61 ssamtstigf rvfsclddgm ghasverild twqeegiens qeilkaldfs ldgninltel
      121 tlalenellv tknsihqaal asfkaeirhl lervdqvvre keklrsdldk aeklkslmas
      181 evddhhaaie rrneynlrkl deeykeriaa lknelrkere qilqqagkqr leleqeieka
      241 kteenyirdr lalslkensr lenellenae klaeyenltn klqrnlenvl aekvlqdqvd
      301 elqseleeyr aqgrvlrlpl knspseevea nsggiepehg lgseecnpln msieaelvie
      361 qmkeqhhrdi cclrleledk vrhyekqlde tvvsckkaqe nmkqrhenet htlekqisdl
      421 kneiaelqgq aavlkeahhe atcrheeekk qlqvkleeek thlqeklrlq hemelkarlt
      481 qaqasferer eglqssawte ekvrgltqel eqfhqeqlts lvekhtleke elrkellekh
      541 qrelqegrye seklqqensi lrneittlne edsisnlklg tlngsqeemw qktetvkqen
      601 aavqkmvenl kkqiselkik nqqldlente lsqknsqnqe klqelnqrlt emlcqkekep
      661 gnsaleereq ekfnlkeele rckvqsstlv ssleaelsev kiqthivqqe nhllkdelek
      721 mkqlhrcpdl sdfqqkissv lsynekllke kealseelns cvdklakssl lehriatmkq
      781 eqkswehqsa slksqlvasq ekvqnledtv qnvnlqmsrm ksdlrvtqqe kealkqevms
      841 lhkqlqnagg kswapeiath psglhnqqkr lswdkldhlm neeqqllwqe nerlqtmvqn
      901 tkaelthsre kvrqlesnll pkhqkhlnps gtmnpteqek lslkrecdqf qkeqspanrk
      961 vsqmnsleqe letihleneg lkkkqvklde qlmemqhlrs tatpspspha wdlqllqqqa
     1021 cpmvpreqfl qlqrqllqae rinqhlqeel enrtsetntp qgnqeqlvtv meermieveq
     1081 klklvkrllq ekvnqlkeql ckntkadamv kdlyvenaql lkalevteqr qktaekknyl
     1141 leekiaslsn ivrnltpapl tstpplrs
//
LOCUS       XP_047287409            1198 aa            linear   PRI 05-AUG-2025
DEFINITION  ninein isoform X23 [Homo sapiens].
ACCESSION   XP_047287409
VERSION     XP_047287409.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431453.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1198
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1198
                     /product="ninein isoform X23"
                     /calculated_mol_wt=139525
     Region          132..944
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1198
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /coded_by="XM_047431453.1:695..4291"
                     /db_xref="GeneID:51199"
                     /db_xref="HGNC:HGNC:14906"
                     /db_xref="MIM:608684"
ORIGIN      
        1 mleevfhnld pdgtmsvedf fyglfkngks ltpsastpyr qlkrhlsmqs fdesgrrttt
       61 ssamtstigf rvfsclddgm ghasverild twqeegiens qeilkaldfs ldgninltel
      121 tlalenellv tknsihqaal asfkaeirhl lervdqvvre keklrsdldk aeklkslmas
      181 evddhhaaie rrneynlrkl deeykeriaa lknelrkere qilqqagkqr leleqeieka
      241 kteenyirdr lalslkensr lenellenae klaeyenltn klqrnlenvl aekfgdldps
      301 saefflqeer ltqmrneyer qcrvlqdqvd elqseleeyr aqgrvlrlpl knspseevea
      361 nsggiepehg lgseecnpln msieaelvie qmkeqhhrdi cclrleledk vrhyekqlde
      421 tvvsckkaqe nmkqrhenet htlekqisdl kneiaelqgq aavlkeahhe atcrheeekk
      481 qlqvkleeek thlqeklrlq hemelkarlt qaqasferer eglqssawte ekvrgltqel
      541 eqfhqeqlts lvekhtleke elrkellekh qrelqegrye seklqqensi lrneittlne
      601 edsisnlklg tlngsqeemw qktetvkqen aavqkmvenl kkqiselkik nqqldlente
      661 lsqknsqnqe klqelnqrlt emlcqkekep gnsaleereq ekfnlkeele rckvqsstlv
      721 ssleaelsev kiqthivqqe nhllkdelek mkqlhrcpdl sdfqqkissv lsynekllke
      781 kealseelns cvdklakssl lehriatmkq eqkswehqsa slksqlvasq ekvqnledtv
      841 qnvnlqmsrm ksdlrvtqqe kealkqevms lhkqlqnagg kswapeiath psglhnqqkr
      901 lswdkldhlm neeqqllwqe nerlqtmvqn tkaelthsre kvrqlesnll pkhqkhlnps
      961 gtmnpteqek lslkrecdqf qkeqspanrk vsqmnsleqe letihleneg lkkkqvklde
     1021 qlmemqhlrs tatpspspha wdlqllqqqa cpmvpreqfl qlqrqllqae rinqhlqeel
     1081 enrtsetntp qgnqeqlvtv meermieveq klklvkrllq ekvnqlkeql ckntkadamv
     1141 kdlyvenaql lkalevteqr qktaekknyl leekiaslsn ivrnltpapl tstpplrs
//
LOCUS       XP_047287410            1276 aa            linear   PRI 05-AUG-2025
DEFINITION  ninein isoform X26 [Homo sapiens].
ACCESSION   XP_047287410
VERSION     XP_047287410.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431454.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1276
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1276
                     /product="ninein isoform X26"
                     /calculated_mol_wt=147855
     Region          354..1166
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1276
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /coded_by="XM_047431454.1:233..4063"
                     /db_xref="GeneID:51199"
                     /db_xref="HGNC:HGNC:14906"
                     /db_xref="MIM:608684"
ORIGIN      
        1 mdeveqdqhe arlkelfdsf dttgtgslgq eeltdlchml sleevapvlq qtllqdnllg
       61 rvhfdqfkea lililsrtls neehfqepdc sleaqpkyvr ggkrygrrsl pefqesveef
      121 pevtviepld eearpshipa gdcsehwktq rseeyeaegq lrfwnpddln asqsgssppq
      181 dwieeklqev cedlgitrdg hlnrkklvsi ceqyglqnvd gemleevfhn ldpdgtmsve
      241 dffyglfkng ksltpsastp yrqlkrhlsm qsfdesgrrt ttssamtsti gfrvfscldd
      301 gmghasveri ldtwqeegie nsqeilkald fsldgninlt eltlalenel lvtknsihqa
      361 alasfkaeir hllervdqvv rekeklrsdl dkaeklkslm asevddhhaa ierrneynlr
      421 kldeeykeri aalknelrke reqilqqagk qrleleqeie kakteenyir drlalslken
      481 srlenellen aeklaeyenl tnklqrnlen vlaekfgdld pssaefflqe erltqmrney
      541 erqcrvlqdq vdelqselee yraqgrvlrl plknspseev eansggiepe hglgseecnp
      601 lnmsieaelv ieqmkeqhhr dicclrlele dkvrhyekql detvvsckka qenmkqrhen
      661 ethtlekqis dlkneiaelq gqaavlkeah heatcrheee kkqlqvklee ekthlqeklr
      721 lqhemelkar ltqaqasfer ereglqssaw teekvrgltq eleqfhqeql tslvekhtle
      781 keelrkelle khqrelqegr yeseklqqen silrneittl needsisnlk lgtlngsqee
      841 mwqktetvkq enaavqkmve nlkkqiselk iknqqldlen telsqknsqn qeklqelnqr
      901 ltemlcqkek epgnsaleer eqekfnlkee lerckvqsst lvssleaels evkiqthivq
      961 qenhllkdel ekmkqlhrcp dlsdfqqkis svlsynekll kekealseel nscvdklaks
     1021 sllehriatm kqeqkswehq saslksqlva sqekvqnled tvqnvnlqms rmksdlrvtq
     1081 qekealkqev mslhkqlqna ggkswapeia thpsglhnqq krlswdkldh lmneeqqllw
     1141 qenerlqtmv qntkaelths rekvrqlesn llpkhqkhln psgtmnpteq eklslkrecd
     1201 qfqkeqspan rkvsqmnsle qeletihlen eglkkkqvkl deqlmensvv gssregcssl
     1261 peivcedaap evhcda
//
LOCUS       XP_005267806             422 aa            linear   PRI 05-AUG-2025
DEFINITION  ena/VASP-like protein isoform X1 [Homo sapiens].
ACCESSION   XP_005267806
VERSION     XP_005267806.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267749.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..422
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..422
                     /product="ena/VASP-like protein isoform X1"
                     /calculated_mol_wt=45260
     Region          11..119
                     /region_name="EVH1_Ena_VASP-like"
                     /note="Enabled/VASP family EVH1 domain; cd01207"
                     /db_xref="CDD:269918"
     Site            order(22,29,76,78,84,86,88)
                     /site_type="other"
                     /note="proline-rich peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:269918"
     Region          222..247
                     /region_name="WH2_hVASP-like"
                     /note="Wiskott-Aldrich syndrome protein (WASP)-homology
                     domain 2 (WH2) of human Vasodilator-stimulated
                     phosphoprotein and related proteins; cd22185"
                     /db_xref="CDD:409225"
     Site            order(229..230,232..233,236,238..242)
                     /site_type="other"
                     /note="actin-binding motif [polypeptide binding]"
                     /db_xref="CDD:409225"
     Region          238..241
                     /region_name="actin-binding sequence"
                     /note="actin-binding sequence [structural motif]"
                     /db_xref="CDD:409225"
     Region          384..417
                     /region_name="VASP_tetra"
                     /note="VASP tetramerization domain; pfam08776"
                     /db_xref="CDD:462599"
     CDS             1..422
                     /gene="EVL"
                     /gene_synonym="RNB6"
                     /coded_by="XM_005267749.4:284..1552"
                     /db_xref="GeneID:51466"
                     /db_xref="HGNC:HGNC:20234"
                     /db_xref="MIM:616912"
ORIGIN      
        1 mfafeefseq sicqarasvm vyddtskkwv pikpgqqgfs riniyhntas ntfrvvgvkl
       61 qdqqvvinys ivkglkynqa tptfhqwrda rqvyglnfas keeattfsna mlfalnimns
      121 qeggpssqrq vqngpspdem diqrrqvmeq hqqqrqesle rrtsatgpil ppghpssaas
      181 apvscsgppp pppppvpppp tgatpppppp lpaggaqgss hdessmsgla aaiagaklrr
      241 vqrpedasgg sspsgtsksd anrassgggg gglmeemnkl lakrrkaasq sdkpaekked
      301 esqmedpsts pspgtraasq ppnsseagrk pwersnsvek pvssilsrtp svakspeaks
      361 plqsqphsrm kpagsvndma ldafdldrmk qeileevvre lhkvkeeiid airqelsgis
      421 tt
//
LOCUS       XP_047287416             403 aa            linear   PRI 05-AUG-2025
DEFINITION  ena/VASP-like protein isoform X2 [Homo sapiens].
ACCESSION   XP_047287416
VERSION     XP_047287416.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431460.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..403
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..403
                     /product="ena/VASP-like protein isoform X2"
                     /calculated_mol_wt=43097
     Region          1..100
                     /region_name="EVH1_Ena_VASP-like"
                     /note="Enabled/VASP family EVH1 domain; cd01207"
                     /db_xref="CDD:269918"
     Site            order(3,10,57,59,65,67,69)
                     /site_type="other"
                     /note="proline-rich peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:269918"
     Region          203..228
                     /region_name="WH2_hVASP-like"
                     /note="Wiskott-Aldrich syndrome protein (WASP)-homology
                     domain 2 (WH2) of human Vasodilator-stimulated
                     phosphoprotein and related proteins; cd22185"
                     /db_xref="CDD:409225"
     Site            order(210..211,213..214,217,219..223)
                     /site_type="other"
                     /note="actin-binding motif [polypeptide binding]"
                     /db_xref="CDD:409225"
     Region          219..222
                     /region_name="actin-binding sequence"
                     /note="actin-binding sequence [structural motif]"
                     /db_xref="CDD:409225"
     Region          365..398
                     /region_name="VASP_tetra"
                     /note="VASP tetramerization domain; pfam08776"
                     /db_xref="CDD:462599"
     CDS             1..403
                     /gene="EVL"
                     /gene_synonym="RNB6"
                     /coded_by="XM_047431460.1:1101..2312"
                     /db_xref="GeneID:51466"
                     /db_xref="HGNC:HGNC:20234"
                     /db_xref="MIM:616912"
ORIGIN      
        1 mvyddtskkw vpikpgqqgf sriniyhnta sntfrvvgvk lqdqqvviny sivkglkynq
       61 atptfhqwrd arqvyglnfa skeeattfsn amlfalnimn sqeggpssqr qvqngpspde
      121 mdiqrrqvme qhqqqrqesl errtsatgpi lppghpssaa sapvscsgpp ppppppvppp
      181 ptgatppppp plpaggaqgs shdessmsgl aaaiagaklr rvqrpedasg gsspsgtsks
      241 danrassggg ggglmeemnk llakrrkaas qsdkpaekke desqmedpst spspgtraas
      301 qppnsseagr kpwersnsve kpvssilsrt psvakspeak splqsqphsr mkpagsvndm
      361 aldafdldrm kqeileevvr elhkvkeeii dairqelsgi stt
//
LOCUS       XP_047287418             401 aa            linear   PRI 05-AUG-2025
DEFINITION  ena/VASP-like protein isoform X3 [Homo sapiens].
ACCESSION   XP_047287418
VERSION     XP_047287418.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431462.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..401
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..401
                     /product="ena/VASP-like protein isoform X3"
                     /calculated_mol_wt=43045
     Region          11..119
                     /region_name="EVH1_Ena_VASP-like"
                     /note="Enabled/VASP family EVH1 domain; cd01207"
                     /db_xref="CDD:269918"
     Site            order(22,29,76,78,84,86,88)
                     /site_type="other"
                     /note="proline-rich peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:269918"
     Region          222..247
                     /region_name="WH2_hVASP-like"
                     /note="Wiskott-Aldrich syndrome protein (WASP)-homology
                     domain 2 (WH2) of human Vasodilator-stimulated
                     phosphoprotein and related proteins; cd22185"
                     /db_xref="CDD:409225"
     Site            order(229..230,232..233,236,238..242)
                     /site_type="other"
                     /note="actin-binding motif [polypeptide binding]"
                     /db_xref="CDD:409225"
     Region          238..241
                     /region_name="actin-binding sequence"
                     /note="actin-binding sequence [structural motif]"
                     /db_xref="CDD:409225"
     Region          363..396
                     /region_name="VASP_tetra"
                     /note="VASP tetramerization domain; pfam08776"
                     /db_xref="CDD:462599"
     CDS             1..401
                     /gene="EVL"
                     /gene_synonym="RNB6"
                     /coded_by="XM_047431462.1:284..1489"
                     /db_xref="GeneID:51466"
                     /db_xref="HGNC:HGNC:20234"
                     /db_xref="MIM:616912"
ORIGIN      
        1 mfafeefseq sicqarasvm vyddtskkwv pikpgqqgfs riniyhntas ntfrvvgvkl
       61 qdqqvvinys ivkglkynqa tptfhqwrda rqvyglnfas keeattfsna mlfalnimns
      121 qeggpssqrq vqngpspdem diqrrqvmeq hqqqrqesle rrtsatgpil ppghpssaas
      181 apvscsgppp pppppvpppp tgatpppppp lpaggaqgss hdessmsgla aaiagaklrr
      241 vqrpedasgg sspsgtsksd anrassgggg gglmeemnkl lakrrkaasq sdkpaekked
      301 esqmedpsts pspgtraasq ppnsseagrk pwersnsvek pvssilsrmk pagsvndmal
      361 dafdldrmkq eileevvrel hkvkeeiida irqelsgist t
//
LOCUS       XP_047287419             397 aa            linear   PRI 05-AUG-2025
DEFINITION  ena/VASP-like protein isoform X4 [Homo sapiens].
ACCESSION   XP_047287419
VERSION     XP_047287419.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431463.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..397
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..397
                     /product="ena/VASP-like protein isoform X4"
                     /calculated_mol_wt=42447
     Region          7..115
                     /region_name="EVH1_Ena_VASP-like"
                     /note="Enabled/VASP family EVH1 domain; cd01207"
                     /db_xref="CDD:269918"
     Site            order(18,25,72,74,80,82,84)
                     /site_type="other"
                     /note="proline-rich peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:269918"
     Region          218..243
                     /region_name="WH2_hVASP-like"
                     /note="Wiskott-Aldrich syndrome protein (WASP)-homology
                     domain 2 (WH2) of human Vasodilator-stimulated
                     phosphoprotein and related proteins; cd22185"
                     /db_xref="CDD:409225"
     Site            order(225..226,228..229,232,234..238)
                     /site_type="other"
                     /note="actin-binding motif [polypeptide binding]"
                     /db_xref="CDD:409225"
     Region          234..237
                     /region_name="actin-binding sequence"
                     /note="actin-binding sequence [structural motif]"
                     /db_xref="CDD:409225"
     Region          359..392
                     /region_name="VASP_tetra"
                     /note="VASP tetramerization domain; pfam08776"
                     /db_xref="CDD:462599"
     CDS             1..397
                     /gene="EVL"
                     /gene_synonym="RNB6"
                     /coded_by="XM_047431463.1:80..1273"
                     /db_xref="GeneID:51466"
                     /db_xref="HGNC:HGNC:20234"
                     /db_xref="MIM:616912"
ORIGIN      
        1 matseqsicq arasvmvydd tskkwvpikp gqqgfsrini yhntasntfr vvgvklqdqq
       61 vvinysivkg lkynqatptf hqwrdarqvy glnfaskeea ttfsnamlfa lnimnsqegg
      121 pssqrqvqng pspdemdiqr rqvmeqhqqq rqeslerrts atgpilppgh pssaasapvs
      181 csgppppppp pvpppptgat pppppplpag gaqgsshdes smsglaaaia gaklrrvqrp
      241 edasggssps gtsksdanra ssgggggglm eemnkllakr rkaasqsdkp aekkedesqm
      301 edpstspspg traasqppns seagrkpwer snsvekpvss ilsrmkpags vndmaldafd
      361 ldrmkqeile evvrelhkvk eeiidairqe lsgistt
//
LOCUS       XP_047287420             395 aa            linear   PRI 05-AUG-2025
DEFINITION  ena/VASP-like protein isoform X5 [Homo sapiens].
ACCESSION   XP_047287420
VERSION     XP_047287420.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431464.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..395
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..395
                     /product="ena/VASP-like protein isoform X5"
                     /calculated_mol_wt=42274
     Region          5..113
                     /region_name="EVH1_Ena_VASP-like"
                     /note="Enabled/VASP family EVH1 domain; cd01207"
                     /db_xref="CDD:269918"
     Site            order(16,23,70,72,78,80,82)
                     /site_type="other"
                     /note="proline-rich peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:269918"
     Region          216..241
                     /region_name="WH2_hVASP-like"
                     /note="Wiskott-Aldrich syndrome protein (WASP)-homology
                     domain 2 (WH2) of human Vasodilator-stimulated
                     phosphoprotein and related proteins; cd22185"
                     /db_xref="CDD:409225"
     Site            order(223..224,226..227,230,232..236)
                     /site_type="other"
                     /note="actin-binding motif [polypeptide binding]"
                     /db_xref="CDD:409225"
     Region          232..235
                     /region_name="actin-binding sequence"
                     /note="actin-binding sequence [structural motif]"
                     /db_xref="CDD:409225"
     Region          357..390
                     /region_name="VASP_tetra"
                     /note="VASP tetramerization domain; pfam08776"
                     /db_xref="CDD:462599"
     CDS             1..395
                     /gene="EVL"
                     /gene_synonym="RNB6"
                     /coded_by="XM_047431464.1:632..1819"
                     /db_xref="GeneID:51466"
                     /db_xref="HGNC:HGNC:20234"
                     /db_xref="MIM:616912"
ORIGIN      
        1 mseqsicqar asvmvyddts kkwvpikpgq qgfsriniyh ntasntfrvv gvklqdqqvv
       61 inysivkglk ynqatptfhq wrdarqvygl nfaskeeatt fsnamlfaln imnsqeggps
      121 sqrqvqngps pdemdiqrrq vmeqhqqqrq eslerrtsat gpilppghps saasapvscs
      181 gppppppppv pppptgatpp pppplpagga qgsshdessm sglaaaiaga klrrvqrped
      241 asggsspsgt sksdanrass gggggglmee mnkllakrrk aasqsdkpae kkedesqmed
      301 pstspspgtr aasqppnsse agrkpwersn svekpvssil srmkpagsvn dmaldafdld
      361 rmkqeileev vrelhkvkee iidairqels gistt
//
LOCUS       XP_011535130             370 aa            linear   PRI 05-AUG-2025
DEFINITION  ena/VASP-like protein isoform X6 [Homo sapiens].
ACCESSION   XP_011535130
VERSION     XP_011535130.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536828.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..370
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..370
                     /product="ena/VASP-like protein isoform X6"
                     /calculated_mol_wt=39599
     Region          11..119
                     /region_name="EVH1_Ena_VASP-like"
                     /note="Enabled/VASP family EVH1 domain; cd01207"
                     /db_xref="CDD:269918"
     Site            order(22,29,76,78,84,86,88)
                     /site_type="other"
                     /note="proline-rich peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:269918"
     Region          222..247
                     /region_name="WH2_hVASP-like"
                     /note="Wiskott-Aldrich syndrome protein (WASP)-homology
                     domain 2 (WH2) of human Vasodilator-stimulated
                     phosphoprotein and related proteins; cd22185"
                     /db_xref="CDD:409225"
     Site            order(229..230,232..233,236,238..242)
                     /site_type="other"
                     /note="actin-binding motif [polypeptide binding]"
                     /db_xref="CDD:409225"
     Region          238..241
                     /region_name="actin-binding sequence"
                     /note="actin-binding sequence [structural motif]"
                     /db_xref="CDD:409225"
     CDS             1..370
                     /gene="EVL"
                     /gene_synonym="RNB6"
                     /coded_by="XM_011536828.3:284..1396"
                     /db_xref="GeneID:51466"
                     /db_xref="HGNC:HGNC:20234"
                     /db_xref="MIM:616912"
ORIGIN      
        1 mfafeefseq sicqarasvm vyddtskkwv pikpgqqgfs riniyhntas ntfrvvgvkl
       61 qdqqvvinys ivkglkynqa tptfhqwrda rqvyglnfas keeattfsna mlfalnimns
      121 qeggpssqrq vqngpspdem diqrrqvmeq hqqqrqesle rrtsatgpil ppghpssaas
      181 apvscsgppp pppppvpppp tgatpppppp lpaggaqgss hdessmsgla aaiagaklrr
      241 vqrpedasgg sspsgtsksd anrassgggg gglmeemnkl lakrrkaasq sdkpaekked
      301 esqmgylafp gapgstdqpg srrdwdsrst lqrgtsarsp erprdnhrhq ntvaslqpqp
      361 wgsediagls
//
LOCUS       XP_047287421             308 aa            linear   PRI 05-AUG-2025
DEFINITION  ena/VASP-like protein isoform X7 [Homo sapiens].
ACCESSION   XP_047287421
VERSION     XP_047287421.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431465.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..308
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..308
                     /product="ena/VASP-like protein isoform X7"
                     /calculated_mol_wt=32074
     Region          108..133
                     /region_name="WH2_hVASP-like"
                     /note="Wiskott-Aldrich syndrome protein (WASP)-homology
                     domain 2 (WH2) of human Vasodilator-stimulated
                     phosphoprotein and related proteins; cd22185"
                     /db_xref="CDD:409225"
     Site            order(115..116,118..119,122,124..128)
                     /site_type="other"
                     /note="actin-binding motif [polypeptide binding]"
                     /db_xref="CDD:409225"
     Region          124..127
                     /region_name="actin-binding sequence"
                     /note="actin-binding sequence [structural motif]"
                     /db_xref="CDD:409225"
     Region          270..303
                     /region_name="VASP_tetra"
                     /note="VASP tetramerization domain; pfam08776"
                     /db_xref="CDD:462599"
     CDS             1..308
                     /gene="EVL"
                     /gene_synonym="RNB6"
                     /coded_by="XM_047431465.1:31..957"
                     /db_xref="GeneID:51466"
                     /db_xref="HGNC:HGNC:20234"
                     /db_xref="MIM:616912"
ORIGIN      
        1 mnggsltscg pssqrqvqng pspdemdiqr rqvmeqhqqq rqeslerrts atgpilppgh
       61 pssaasapvs csgppppppp pvpppptgat pppppplpag gaqgsshdes smsglaaaia
      121 gaklrrvqrp edasggssps gtsksdanra ssgggggglm eemnkllakr rkaasqsdkp
      181 aekkedesqm edpstspspg traasqppns seagrkpwer snsvekpvss ilsrtpsvak
      241 speaksplqs qphsrmkpag svndmaldaf dldrmkqeil eevvrelhkv keeiidairq
      301 elsgistt
//
LOCUS       XP_024305395             325 aa            linear   PRI 05-AUG-2025
DEFINITION  JNK1/MAPK8-associated membrane protein isoform X1 [Homo sapiens].
ACCESSION   XP_024305395
VERSION     XP_024305395.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449627.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..325
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..325
                     /product="JNK1/MAPK8-associated membrane protein isoform
                     X1"
                     /calculated_mol_wt=36662
     Region          23..314
                     /region_name="JAMP"
                     /note="JNK1/MAPK8-associated membrane protein; pfam05571"
                     /db_xref="CDD:398936"
     CDS             1..325
                     /gene="JKAMP"
                     /gene_synonym="C14orf100; C24orf100; CDA06; HSPC213;
                     HSPC327; JAMP"
                     /coded_by="XM_024449627.2:159..1136"
                     /db_xref="GeneID:51528"
                     /db_xref="HGNC:HGNC:20184"
                     /db_xref="MIM:611176"
ORIGIN      
        1 mkgeiqqslg awvlltvdiq paclglycgk tllfkngste iygecgvcpr gqrtnaqkyc
       61 qpctespely dwlylgfmam lplvlhwffi ewysgkksss alfqhitalf ecsmaaiitl
      121 lvsdpvgvly irscrvlmls dwytmlynps pdyvttvhct heavyplyti vfiyyafclv
      181 lmmllrpllv kkiacglgks drfksiyaal yffpiltvlq avgggllyya fpyiilvlsl
      241 vtlavymsas eiencydllv rkkrlivlfs hwllhaygii sisrvdkleq dlpllalvpt
      301 palfylftak ftepsrilse gangh
//
LOCUS       XP_047287423             248 aa            linear   PRI 05-AUG-2025
DEFINITION  JNK1/MAPK8-associated membrane protein isoform X2 [Homo sapiens].
ACCESSION   XP_047287423
VERSION     XP_047287423.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431467.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..248
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..248
                     /product="JNK1/MAPK8-associated membrane protein isoform
                     X2"
                     /calculated_mol_wt=28081
     Region          1..237
                     /region_name="JAMP"
                     /note="JNK1/MAPK8-associated membrane protein; pfam05571"
                     /db_xref="CDD:398936"
     CDS             1..248
                     /gene="JKAMP"
                     /gene_synonym="C14orf100; C24orf100; CDA06; HSPC213;
                     HSPC327; JAMP"
                     /coded_by="XM_047431467.1:171..917"
                     /db_xref="GeneID:51528"
                     /db_xref="HGNC:HGNC:20184"
                     /db_xref="MIM:611176"
ORIGIN      
        1 mamlplvlhw ffiewysgkk sssalfqhit alfecsmaai itllvsdpvg vlyirscrvl
       61 mlsdwytmly npspdyvttv hctheavypl ytivfiyyaf clvlmmllrp llvkkiacgl
      121 gksdrfksiy aalyffpilt vlqavgggll yyafpyiilv lslvtlavym saseiencyd
      181 llvrkkrliv lfshwllhay giisisrvdk leqdlpllal vptpalfylf takftepsri
      241 lsegangh
//
LOCUS       XP_005267811             322 aa            linear   PRI 05-AUG-2025
DEFINITION  MAP3K12-binding inhibitory protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_005267811
VERSION     XP_005267811.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267754.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..322
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..322
                     /product="MAP3K12-binding inhibitory protein 1 isoform X1"
                     /calculated_mol_wt=36700
     CDS             1..322
                     /gene="MBIP"
                     /coded_by="XM_005267754.5:50..1018"
                     /db_xref="GeneID:51562"
                     /db_xref="HGNC:HGNC:20427"
                     /db_xref="MIM:609431"
ORIGIN      
        1 maaatelnrp ssgdrnlerr crpnlsrevl yeifrslhtl vgqldlrddv vkitidwnkl
       61 qslsafqpal lfsaleqhil ylqpflaklq spikeentta veeigrtemg nknevndkfs
      121 igdlqeeekh kesdlrdvkk tqihfdpevv qikagkaeid rrisafierk qaeinennvr
      181 efcnvidcnq vsrvvntygp qtrpegipgs ghkpnsmlrd cgnqaveerl qnieahlrlq
      241 tggpvprdiy qrikkledki lelegispey fqsvsfsgkr rkvqppqqny slaeldekis
      301 alkqallrks reaesmathh lp
//
LOCUS       XP_047287425             321 aa            linear   PRI 05-AUG-2025
DEFINITION  MAP3K12-binding inhibitory protein 1 isoform X2 [Homo sapiens].
ACCESSION   XP_047287425
VERSION     XP_047287425.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431469.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..321
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..321
                     /product="MAP3K12-binding inhibitory protein 1 isoform X2"
                     /calculated_mol_wt=36572
     CDS             1..321
                     /gene="MBIP"
                     /coded_by="XM_047431469.1:50..1015"
                     /db_xref="GeneID:51562"
                     /db_xref="HGNC:HGNC:20427"
                     /db_xref="MIM:609431"
ORIGIN      
        1 maaatelnrp ssgdrnlerr crpnlsrevl yeifrslhtl vgqldlrddv vkitidwnkl
       61 qslsafqpal lfsaleqhil ylqpflaklq spikeentta veeigrtemg nknevndkfs
      121 igdlqeeekh kesdlrdvkk tqihfdpevv qikagkaeid rrisafierk qaeinennvr
      181 efcnvidcnq vsrvvntygp qtrpegipgs ghkpnsmlrd cgnqaveerl qnieahlrlq
      241 tggpvprdiy qrikkledki lelegispey fqsvsfsgkr rkvqppqnys laeldekisa
      301 lkqallrksr eaesmathhl p
//
LOCUS       XP_005267813             281 aa            linear   PRI 05-AUG-2025
DEFINITION  MAP3K12-binding inhibitory protein 1 isoform X3 [Homo sapiens].
ACCESSION   XP_005267813
VERSION     XP_005267813.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267756.6
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..281
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..281
                     /product="MAP3K12-binding inhibitory protein 1 isoform X3"
                     /calculated_mol_wt=31990
     CDS             1..281
                     /gene="MBIP"
                     /coded_by="XM_005267756.6:50..895"
                     /db_xref="GeneID:51562"
                     /db_xref="HGNC:HGNC:20427"
                     /db_xref="MIM:609431"
ORIGIN      
        1 maaatelnrp ssgdrnlerr crpnlsrevl yeifrslhtl vgqldlrddv vkitidwnkl
       61 qslsafqpal lfsaleqhil ylqpflaklq spikeentta veeigrtemg nknevndkfs
      121 igdlqeeekh kesdlrdvkk tqihfdpevv qikagkaeid rrisafierk qaeinennvr
      181 efcnvidcnq enscartdai ftpypgfksh vkvsrvvnty gpqtrpegip gsghkpnsml
      241 rdcgnqavee rlqnieahlr lqtelfwkkk kssttsklft g
//
LOCUS       XP_047287426             260 aa            linear   PRI 05-AUG-2025
DEFINITION  MAP3K12-binding inhibitory protein 1 isoform X4 [Homo sapiens].
ACCESSION   XP_047287426
VERSION     XP_047287426.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431470.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..260
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..260
                     /product="MAP3K12-binding inhibitory protein 1 isoform X4"
                     /calculated_mol_wt=29642
     CDS             1..260
                     /gene="MBIP"
                     /coded_by="XM_047431470.1:50..832"
                     /db_xref="GeneID:51562"
                     /db_xref="HGNC:HGNC:20427"
                     /db_xref="MIM:609431"
ORIGIN      
        1 maaatelnrp ssgdrnlerr crpnlsrevl yeifrslhtl vgqldlrddv vkitidwnkl
       61 qslsafqpal lfsaleqhil ylqpflaklq spikeentta veeigrtemg nknevndkfs
      121 igdlqeeekh kesdlrdvkk tqihfdpevv qikagkaeid rrisafierk qaeinennvr
      181 efcnvidcnq vsrvvntygp qtrpegipgs ghkpnsmlrd cgnqaveerl qnieahlrlq
      241 telfwkkkks sttstelftg
//
LOCUS       XP_016876856             259 aa            linear   PRI 05-AUG-2025
DEFINITION  MAP3K12-binding inhibitory protein 1 isoform X5 [Homo sapiens].
ACCESSION   XP_016876856
VERSION     XP_016876856.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021367.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..259
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..259
                     /product="MAP3K12-binding inhibitory protein 1 isoform X5"
                     /calculated_mol_wt=29540
     CDS             1..259
                     /gene="MBIP"
                     /coded_by="XM_017021367.3:50..829"
                     /db_xref="GeneID:51562"
                     /db_xref="HGNC:HGNC:20427"
                     /db_xref="MIM:609431"
ORIGIN      
        1 maaatelnrp ssgdrnlerr crpnlsrevl yeifrslhtl vgqldlrddv vkitidwnkl
       61 qslsafqpal lfsaleqhil ylqpflaklq spikeentta veeigrtemg nknevndkfs
      121 igdlqeeekh kesdlrdvkk tqihfdpevv qikagkaeid rrisafierk qaeinennvr
      181 efcnvidcnq vsrvvntygp qtrpegipgs ghkpnsmlrd cgnqaveerl qnieahlrlq
      241 telfwkkkks sttsklftg
//
LOCUS       XP_005267815             635 aa            linear   PRI 05-AUG-2025
DEFINITION  ankyrin repeat and SOCS box protein 2 isoform X1 [Homo sapiens].
ACCESSION   XP_005267815
VERSION     XP_005267815.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267758.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..635
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..635
                     /product="ankyrin repeat and SOCS box protein 2 isoform
                     X1"
                     /calculated_mol_wt=70081
     Region          109..202
                     /region_name="Ank_2"
                     /note="Ankyrin repeats (3 copies); pfam12796"
                     /db_xref="CDD:463710"
     Region          137..169
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          165..400
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          173..202
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          204..235
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(237,239,243..244,247..249,251..252,256,259,268,270,
                     272,276..277,280..282,284..285,289,292,301,303,305,
                     309..310,313..315,317..318,322,325,334)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          237..268
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          270..301
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          303..334
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          368..396
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          373..469
                     /region_name="Ank_2"
                     /note="Ankyrin repeats (3 copies); pfam12796"
                     /db_xref="CDD:463710"
     Region          401..440
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          442..469
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          473..501
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          591..635
                     /region_name="SOCS_ASB2"
                     /note="SOCS (suppressors of cytokine signaling) box of
                     ASB2-like proteins. ASB family members have a C-terminal
                     SOCS box and an N-terminal ankyrin-related sequence. ASB2
                     targets specific proteins to destruction by the proteasome
                     in leukemia cells that have been...; cd03721"
                     /db_xref="CDD:239691"
     Site            order(592..597,603,613,619,624)
                     /site_type="other"
                     /note="putative elongin B/C interaction [polypeptide
                     binding]"
                     /db_xref="CDD:239691"
     CDS             1..635
                     /gene="ASB2"
                     /gene_synonym="ASB-2"
                     /coded_by="XM_005267758.4:262..2169"
                     /db_xref="GeneID:51676"
                     /db_xref="HGNC:HGNC:16012"
                     /db_xref="MIM:605759"
ORIGIN      
        1 matqistrgs qctigqeeys lysslsedel vqmaieqsla dktrgpttae atasactnrq
       61 pahfypwtrs tappesspar apmglfqgvm qkyssslfkt sqlapadpli kaikdgdeea
      121 lktmikegkn laepnkegwl plheaayygq vgclkvlqra ypgtidqrtl qeetavylat
      181 crghldclls llqagaepdi snksretply kacerknaea vkilvqhnad tnhrcnrgwt
      241 alhesvsrnd levmqilvsg gakvesknay gitplfvaaq sgqlealrfl akygadintq
      301 asdnasalye ackneheevv efllsqgada nktnkdgllp lhiaskkgny rivqmllpvt
      361 srtrirrsgv splhlaaern hdevlealls arfdvntpla perarlyedr rssalyfavv
      421 nnnvyatell lqhgadpnrd vispllvair hgclrtmqll ldhganiday iathptafpa
      481 timfamkcls llkflmdlgc dgepcfscly gngphppapq pssrfndapa adkepsvvqf
      541 cefvsapevs rwagpiidvl ldyvgnvqlc srlkehidsf edwavikeka epprplahlc
      601 rlrvrkaigk yriklldtlp lpgrlirylk yentq
//
LOCUS       XP_016876858             600 aa            linear   PRI 05-AUG-2025
DEFINITION  ankyrin repeat and SOCS box protein 2 isoform X2 [Homo sapiens].
ACCESSION   XP_016876858
VERSION     XP_016876858.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021369.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..600
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..600
                     /product="ankyrin repeat and SOCS box protein 2 isoform
                     X2"
                     /calculated_mol_wt=66398
     Region          74..167
                     /region_name="Ank_2"
                     /note="Ankyrin repeats (3 copies); pfam12796"
                     /db_xref="CDD:463710"
     Region          102..134
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          130..365
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          138..167
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          169..200
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(202,204,208..209,212..214,216..217,221,224,233,235,
                     237,241..242,245..247,249..250,254,257,266,268,270,
                     274..275,278..280,282..283,287,290,299)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          202..233
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          235..266
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          268..299
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          333..361
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          338..434
                     /region_name="Ank_2"
                     /note="Ankyrin repeats (3 copies); pfam12796"
                     /db_xref="CDD:463710"
     Region          366..405
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          407..434
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          438..466
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          556..600
                     /region_name="SOCS_ASB2"
                     /note="SOCS (suppressors of cytokine signaling) box of
                     ASB2-like proteins. ASB family members have a C-terminal
                     SOCS box and an N-terminal ankyrin-related sequence. ASB2
                     targets specific proteins to destruction by the proteasome
                     in leukemia cells that have been...; cd03721"
                     /db_xref="CDD:239691"
     Site            order(557..562,568,578,584,589)
                     /site_type="other"
                     /note="putative elongin B/C interaction [polypeptide
                     binding]"
                     /db_xref="CDD:239691"
     CDS             1..600
                     /gene="ASB2"
                     /gene_synonym="ASB-2"
                     /coded_by="XM_017021369.3:211..2013"
                     /db_xref="GeneID:51676"
                     /db_xref="HGNC:HGNC:16012"
                     /db_xref="MIM:605759"
ORIGIN      
        1 matqistrgs qctigqeeys lysslsedel vqmaieqsla dktrgpttae atasactnrq
       61 pahfypwtrp adplikaikd gdeealktmi kegknlaepn kegwlplhea ayygqvgclk
      121 vlqraypgti dqrtlqeeta vylatcrghl dcllsllqag aepdisnksr etplykacer
      181 knaeavkilv qhnadtnhrc nrgwtalhes vsrndlevmq ilvsggakve sknaygitpl
      241 fvaaqsgqle alrflakyga dintqasdna salyeackne heevveflls qgadanktnk
      301 dgllplhias kkgnyrivqm llpvtsrtri rrsgvsplhl aaernhdevl eallsarfdv
      361 ntplaperar lyedrrssal yfavvnnnvy atelllqhga dpnrdvispl lvairhgclr
      421 tmqllldhga nidayiathp tafpatimfa mkclsllkfl mdlgcdgepc fsclygngph
      481 ppapqpssrf ndapaadkep svvqfcefvs apevsrwagp iidvlldyvg nvqlcsrlke
      541 hidsfedwav ikekaepprp lahlcrlrvr kaigkyrikl ldtlplpgrl irylkyentq
//
LOCUS       XP_011535136             583 aa            linear   PRI 05-AUG-2025
DEFINITION  ankyrin repeat and SOCS box protein 2 isoform X3 [Homo sapiens].
ACCESSION   XP_011535136
VERSION     XP_011535136.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536834.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..583
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..583
                     /product="ankyrin repeat and SOCS box protein 2 isoform
                     X3"
                     /calculated_mol_wt=64348
     Region          106..348
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          108..135
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          137..183
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(185,187,191..192,195..197,199..200,204,207,216,218,
                     220,224..225,228..230,232..233,237,240,249,251,253,
                     257..258,261..263,265..266,270,273,282)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          185..216
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          218..249
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          251..282
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          316..344
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          321..417
                     /region_name="Ank_2"
                     /note="Ankyrin repeats (3 copies); pfam12796"
                     /db_xref="CDD:463710"
     Region          349..388
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          390..417
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          421..449
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          539..583
                     /region_name="SOCS_ASB2"
                     /note="SOCS (suppressors of cytokine signaling) box of
                     ASB2-like proteins. ASB family members have a C-terminal
                     SOCS box and an N-terminal ankyrin-related sequence. ASB2
                     targets specific proteins to destruction by the proteasome
                     in leukemia cells that have been...; cd03721"
                     /db_xref="CDD:239691"
     Site            order(540..545,551,561,567,572)
                     /site_type="other"
                     /note="putative elongin B/C interaction [polypeptide
                     binding]"
                     /db_xref="CDD:239691"
     CDS             1..583
                     /gene="ASB2"
                     /gene_synonym="ASB-2"
                     /coded_by="XM_011536834.4:211..1962"
                     /db_xref="GeneID:51676"
                     /db_xref="HGNC:HGNC:16012"
                     /db_xref="MIM:605759"
ORIGIN      
        1 matqistrgs qctigqeeys lysslsedel vqmaieqsla dktrgpttae atasactnrq
       61 pahfypwtrs tappesspar apmglfqgvm qkyssslfkt sqlapadpli kaikdgdeea
      121 lktmikegkn laepnkegwl plheaayygq vgclkvlqra cerknaeavk ilvqhnadtn
      181 hrcnrgwtal hesvsrndle vmqilvsgga kvesknaygi tplfvaaqsg qlealrflak
      241 ygadintqas dnasalyeac kneheevvef llsqgadank tnkdgllplh iaskkgnyri
      301 vqmllpvtsr trirrsgvsp lhlaaernhd evleallsar fdvntplape rarlyedrrs
      361 salyfavvnn nvyatelllq hgadpnrdvi spllvairhg clrtmqllld hganidayia
      421 thptafpati mfamkclsll kflmdlgcdg epcfsclygn gphppapqps srfndapaad
      481 kepsvvqfce fvsapevsrw agpiidvlld yvgnvqlcsr lkehidsfed wavikekaep
      541 prplahlcrl rvrkaigkyr iklldtlplp grlirylkye ntq
//
LOCUS       XP_047287429             548 aa            linear   PRI 05-AUG-2025
DEFINITION  ankyrin repeat and SOCS box protein 2 isoform X4 [Homo sapiens].
ACCESSION   XP_047287429
VERSION     XP_047287429.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431473.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..548
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..548
                     /product="ankyrin repeat and SOCS box protein 2 isoform
                     X4"
                     /calculated_mol_wt=60665
     Region          71..313
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          73..100
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          102..148
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(150,152,156..157,160..162,164..165,169,172,181,183,
                     185,189..190,193..195,197..198,202,205,214,216,218,
                     222..223,226..228,230..231,235,238,247)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          150..181
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          183..214
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          216..247
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          281..309
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          286..382
                     /region_name="Ank_2"
                     /note="Ankyrin repeats (3 copies); pfam12796"
                     /db_xref="CDD:463710"
     Region          314..353
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          355..382
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          386..414
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          504..548
                     /region_name="SOCS_ASB2"
                     /note="SOCS (suppressors of cytokine signaling) box of
                     ASB2-like proteins. ASB family members have a C-terminal
                     SOCS box and an N-terminal ankyrin-related sequence. ASB2
                     targets specific proteins to destruction by the proteasome
                     in leukemia cells that have been...; cd03721"
                     /db_xref="CDD:239691"
     Site            order(505..510,516,526,532,537)
                     /site_type="other"
                     /note="putative elongin B/C interaction [polypeptide
                     binding]"
                     /db_xref="CDD:239691"
     CDS             1..548
                     /gene="ASB2"
                     /gene_synonym="ASB-2"
                     /coded_by="XM_047431473.1:211..1857"
                     /db_xref="GeneID:51676"
                     /db_xref="HGNC:HGNC:16012"
                     /db_xref="MIM:605759"
ORIGIN      
        1 matqistrgs qctigqeeys lysslsedel vqmaieqsla dktrgpttae atasactnrq
       61 pahfypwtrp adplikaikd gdeealktmi kegknlaepn kegwlplhea ayygqvgclk
      121 vlqracerkn aeavkilvqh nadtnhrcnr gwtalhesvs rndlevmqil vsggakvesk
      181 naygitplfv aaqsgqleal rflakygadi ntqasdnasa lyeacknehe evvefllsqg
      241 adanktnkdg llplhiaskk gnyrivqmll pvtsrtrirr sgvsplhlaa ernhdevlea
      301 llsarfdvnt plaperarly edrrssalyf avvnnnvyat elllqhgadp nrdvispllv
      361 airhgclrtm qllldhgani dayiathpta fpatimfamk clsllkflmd lgcdgepcfs
      421 clygngphpp apqpssrfnd apaadkepsv vqfcefvsap evsrwagpii dvlldyvgnv
      481 qlcsrlkehi dsfedwavik ekaepprpla hlcrlrvrka igkyriklld tlplpgrlir
      541 ylkyentq
//
LOCUS       XP_011535137             533 aa            linear   PRI 05-AUG-2025
DEFINITION  ankyrin repeat and SOCS box protein 2 isoform X5 [Homo sapiens].
ACCESSION   XP_011535137
VERSION     XP_011535137.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536835.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..533
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..533
                     /product="ankyrin repeat and SOCS box protein 2 isoform
                     X5"
                     /calculated_mol_wt=59087
     Region          7..100
                     /region_name="Ank_2"
                     /note="Ankyrin repeats (3 copies); pfam12796"
                     /db_xref="CDD:463710"
     Region          35..67
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          63..298
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          71..100
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          102..133
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(135,137,141..142,145..147,149..150,154,157,166,168,
                     170,174..175,178..180,182..183,187,190,199,201,203,
                     207..208,211..213,215..216,220,223,232)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          135..166
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          168..199
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          201..232
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          266..294
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          271..367
                     /region_name="Ank_2"
                     /note="Ankyrin repeats (3 copies); pfam12796"
                     /db_xref="CDD:463710"
     Region          299..338
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          340..367
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          371..399
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          489..533
                     /region_name="SOCS"
                     /note="SOCS (suppressors of cytokine signaling) box. The
                     SOCS box is found in the C-terminal region of CIS/SOCS
                     family proteins (in combination with a SH2 domain), ASBs
                     (ankyrin repeat-containing proteins with a SOCS box), SSBs
                     (SPRY domain-containing proteins...; cl02533"
                     /db_xref="CDD:470605"
     Site            order(490..495,501,511,517)
                     /site_type="active"
                     /note="elongin B/C interaction [active]"
                     /db_xref="CDD:239641"
     CDS             1..533
                     /gene="ASB2"
                     /gene_synonym="ASB-2"
                     /coded_by="XM_011536835.4:171..1772"
                     /db_xref="GeneID:51676"
                     /db_xref="HGNC:HGNC:16012"
                     /db_xref="MIM:605759"
ORIGIN      
        1 mrpadplika ikdgdeealk tmikegknla epnkegwlpl heaayygqvg clkvlqrayp
       61 gtidqrtlqe etavylatcr ghldcllsll qagaepdisn ksretplyka cerknaeavk
      121 ilvqhnadtn hrcnrgwtal hesvsrndle vmqilvsgga kvesknaygi tplfvaaqsg
      181 qlealrflak ygadintqas dnasalyeac kneheevvef llsqgadank tnkdgllplh
      241 iaskkgnyri vqmllpvtsr trirrsgvsp lhlaaernhd evleallsar fdvntplape
      301 rarlyedrrs salyfavvnn nvyatelllq hgadpnrdvi spllvairhg clrtmqllld
      361 hganidayia thptafpati mfamkclsll kflmdlgcdg epcfsclygn gphppapqps
      421 srfndapaad kepsvvqfce fvsapevsrw agpiidvlld yvgnvqlcsr lkehidsfed
      481 wavikekaep prplahlcrl rvrkaigkyr iklldtlplp grlirylkye ntq
//
LOCUS       XP_005267816             773 aa            linear   PRI 05-AUG-2025
DEFINITION  homeobox protein SIX4 isoform X1 [Homo sapiens].
ACCESSION   XP_005267816
VERSION     XP_005267816.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267759.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..773
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..773
                     /product="homeobox protein SIX4 isoform X1"
                     /calculated_mol_wt=82071
     Region          100..209
                     /region_name="SIX1_SD"
                     /note="Transcriptional regulator, SIX1, N-terminal SD
                     domain; pfam16878"
                     /db_xref="CDD:465293"
     Region          220..274
                     /region_name="homeodomain"
                     /note="Homeodomain; DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; cd00086"
                     /db_xref="CDD:238039"
     Site            order(221,261,264..265,268)
                     /site_type="other"
                     /note="specific DNA base contacts [nucleotide binding]"
                     /db_xref="CDD:238039"
     CDS             1..773
                     /gene="SIX4"
                     /gene_synonym="AREC3"
                     /coded_by="XM_005267759.3:94..2415"
                     /db_xref="GeneID:51804"
                     /db_xref="HGNC:HGNC:10890"
                     /db_xref="MIM:606342"
ORIGIN      
        1 miasaadikq engmesaseg qeahrevagg aavglsppap apfplepgda ataaarvsge
       61 egavaaaaag aaadqvqlhs ellgrhhhaa aaaaqtplaf spdhvacvce alqqggnldr
      121 larflwslpq sdllrgnesl lkaralvafh qgiypelysi leshsfesan hpllqqlwyk
      181 aryteaerar grplgavdky rlrrkfplpr tiwdgeetvy cfkeksrnal kelykqnryp
      241 spaekrhlak itglsltqvs nwfknrrqrd rnpsetqsks esdgnpsted esskghedls
      301 phplssssdg itnlslsshm epvymqqign akislsssgv llngslvpas tspvflngns
      361 fiqgpsgvil nglnvgntqa valnppkmss nivsngismt dilgstsqdv kefkvlqssa
      421 nsatttsysp svpvsfpgli pstevkregi qtvasqdggs vvtfttpvqi nqygivqipn
      481 sgansqflng sigfsplqlp pvsvaasqgn isvssstsdg stftsesttv qqgkvflssl
      541 apsavvytvp ntgqtigsvk qeglerslvf sqlmpvnqna qvnanlssen isgsglhpla
      601 sslvnvspth nfslspstll nptelnrdia dsqpmsapva skstvtsvsn tnyatlqncs
      661 litgqdllsv pmtqaalgei vptaedqvgh pspavhqdfv qehrlvlqsv anmkenflsn
      721 seskatsslm mldskskyvl dgmvdtvced letdkkelak lqtvqldedm qdl
//
LOCUS       XP_047287430             294 aa            linear   PRI 05-AUG-2025
DEFINITION  homeobox protein SIX4 isoform X2 [Homo sapiens].
ACCESSION   XP_047287430
VERSION     XP_047287430.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431474.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 22% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..294
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..294
                     /product="homeobox protein SIX4 isoform X2"
                     /calculated_mol_wt=31910
     Region          108..217
                     /region_name="SIX1_SD"
                     /note="Transcriptional regulator, SIX1, N-terminal SD
                     domain; pfam16878"
                     /db_xref="CDD:465293"
     Region          228..282
                     /region_name="homeodomain"
                     /note="Homeodomain; DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; cd00086"
                     /db_xref="CDD:238039"
     Site            order(229,269,272..273,276)
                     /site_type="other"
                     /note="specific DNA base contacts [nucleotide binding]"
                     /db_xref="CDD:238039"
     CDS             1..294
                     /gene="SIX4"
                     /gene_synonym="AREC3"
                     /coded_by="XM_047431474.1:278..1162"
                     /db_xref="GeneID:51804"
                     /db_xref="HGNC:HGNC:10890"
                     /db_xref="MIM:606342"
ORIGIN      
        1 mssssptgqi asaadikqen gmesasegqe ahrevaggaa vglsppapap fplepgdaat
       61 aaarvsgeeg avaaaaagaa adqvqlhsel lgrhhhaaaa aaqtplafsp dhvacvceal
      121 qqggnldrla rflwslpqsd llrgnesllk aralvafhqg iypelysile shsfesanhp
      181 llqqlwykar yteaerargr plgavdkyrl rrkfplprti wdgeetvycf keksrnalke
      241 lykqnrypsp aekrhlakit glsltqvsnw fknrrqrdrn psetqskral dgvc
//
LOCUS       XP_047287432             148 aa            linear   PRI 05-AUG-2025
DEFINITION  placenta growth factor isoform X1 [Homo sapiens].
ACCESSION   XP_047287432
VERSION     XP_047287432.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431476.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 29% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..148
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..148
                     /product="placenta growth factor isoform X1"
                     /calculated_mol_wt=16466
     Region          49..131
                     /region_name="PDGF"
                     /note="Platelet-derived and vascular endothelial growth
                     factors (PDGF, VEGF) family; smart00141"
                     /db_xref="CDD:197537"
     Site            order(49..52,86,88..91,106..109)
                     /site_type="active"
                     /note="receptor binding interface [active]"
                     /db_xref="CDD:238079"
     Site            order(51,82,86,93,127,129)
                     /site_type="other"
                     /note="cysteine knot motif"
                     /db_xref="CDD:238079"
     Site            order(76,85)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:238079"
     CDS             1..148
                     /gene="PGF"
                     /gene_synonym="D12S1900; PGFL; PIGF; PLGF; PlGF-2;
                     SHGC-10760"
                     /coded_by="XM_047431476.1:523..969"
                     /db_xref="GeneID:5228"
                     /db_xref="HGNC:HGNC:8893"
                     /db_xref="MIM:601121"
ORIGIN      
        1 mpvmrlfpcf lqllaglalp avppqwalsa gngssevevv pfqevwgrsy cralerlvdv
       61 vseypseveh mfspscvsll rctgccgden lhcvpvetan vtmqllkirs gdrpsyvelt
      121 fsqhvrcecr plrekmkper cgdavprr
//
LOCUS       XP_047287434             418 aa            linear   PRI 05-AUG-2025
DEFINITION  alpha-1-antitrypsin isoform X1 [Homo sapiens].
ACCESSION   XP_047287434
VERSION     XP_047287434.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431478.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..418
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..418
                     /product="alpha-1-antitrypsin isoform X1"
                     /calculated_mol_wt=46606
     Region          50..417
                     /region_name="serpinA1_A1AT"
                     /note="serpin family A member 1, alpha-1-antitrypsin;
                     cd02056"
                     /db_xref="CDD:381012"
     Site            order(51,55,59,62,68..70,72..79,123,127,214,231..234,
                     236..237,240,244,253,264,267,270..281,284,287..288,291,
                     296,308..313,315..316,362,371..373,386..401,403..415)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:381012"
     Site            order(248,304,377..385)
                     /site_type="other"
                     /note="trypsin binding site [polypeptide binding]"
                     /db_xref="CDD:381012"
     Site            368..393
                     /site_type="other"
                     /note="reactive center loop (RCL)"
                     /db_xref="CDD:381012"
     CDS             1..418
                     /gene="SERPINA1"
                     /gene_synonym="A1A; A1AT; AAT; alpha1AT; nNIF; PI; PI1;
                     PRO2275"
                     /coded_by="XM_047431478.1:322..1578"
                     /db_xref="GeneID:5265"
                     /db_xref="HGNC:HGNC:8941"
                     /db_xref="MIM:107400"
ORIGIN      
        1 mpssvswgil llaglcclvp vslaedpqgd aaqktdtshh dqdhptfnki tpnlaefafs
       61 lyrqlahqsn stniffspvs iatafamlsl gtkadthdei leglnfnlte ipeaqihegf
      121 qellrtlnqp dsqlqlttgn glflseglkl vdkfledvkk lyhseaftvn fgdteeakkq
      181 indyvekgtq gkivdlvkel drdtvfalvn yiffkgkwer pfevkdteee dfhvdqvttv
      241 kvpmmkrlgm fniqhckkls swvllmkylg nataifflpd egklqhlene lthdiitkfl
      301 enedrrsasl hlpklsitgt ydlksvlgql gitkvfsnga dlsgvteeap lklskavhka
      361 vltidekgte aagamfleai pmsippevkf nkpfvflmie qntksplfmg kvvnptqk
//
LOCUS       XP_047287435             418 aa            linear   PRI 05-AUG-2025
DEFINITION  alpha-1-antitrypsin isoform X1 [Homo sapiens].
ACCESSION   XP_047287435
VERSION     XP_047287435.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431479.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..418
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..418
                     /product="alpha-1-antitrypsin isoform X1"
                     /calculated_mol_wt=46606
     Region          50..417
                     /region_name="serpinA1_A1AT"
                     /note="serpin family A member 1, alpha-1-antitrypsin;
                     cd02056"
                     /db_xref="CDD:381012"
     Site            order(51,55,59,62,68..70,72..79,123,127,214,231..234,
                     236..237,240,244,253,264,267,270..281,284,287..288,291,
                     296,308..313,315..316,362,371..373,386..401,403..415)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:381012"
     Site            order(248,304,377..385)
                     /site_type="other"
                     /note="trypsin binding site [polypeptide binding]"
                     /db_xref="CDD:381012"
     Site            368..393
                     /site_type="other"
                     /note="reactive center loop (RCL)"
                     /db_xref="CDD:381012"
     CDS             1..418
                     /gene="SERPINA1"
                     /gene_synonym="A1A; A1AT; AAT; alpha1AT; nNIF; PI; PI1;
                     PRO2275"
                     /coded_by="XM_047431479.1:426..1682"
                     /db_xref="GeneID:5265"
                     /db_xref="HGNC:HGNC:8941"
                     /db_xref="MIM:107400"
ORIGIN      
        1 mpssvswgil llaglcclvp vslaedpqgd aaqktdtshh dqdhptfnki tpnlaefafs
       61 lyrqlahqsn stniffspvs iatafamlsl gtkadthdei leglnfnlte ipeaqihegf
      121 qellrtlnqp dsqlqlttgn glflseglkl vdkfledvkk lyhseaftvn fgdteeakkq
      181 indyvekgtq gkivdlvkel drdtvfalvn yiffkgkwer pfevkdteee dfhvdqvttv
      241 kvpmmkrlgm fniqhckkls swvllmkylg nataifflpd egklqhlene lthdiitkfl
      301 enedrrsasl hlpklsitgt ydlksvlgql gitkvfsnga dlsgvteeap lklskavhka
      361 vltidekgte aagamfleai pmsippevkf nkpfvflmie qntksplfmg kvvnptqk
//
LOCUS       XP_016876859             418 aa            linear   PRI 05-AUG-2025
DEFINITION  alpha-1-antitrypsin isoform X1 [Homo sapiens].
ACCESSION   XP_016876859
VERSION     XP_016876859.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021370.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..418
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..418
                     /product="alpha-1-antitrypsin isoform X1"
                     /calculated_mol_wt=46606
     Region          50..417
                     /region_name="serpinA1_A1AT"
                     /note="serpin family A member 1, alpha-1-antitrypsin;
                     cd02056"
                     /db_xref="CDD:381012"
     Site            order(51,55,59,62,68..70,72..79,123,127,214,231..234,
                     236..237,240,244,253,264,267,270..281,284,287..288,291,
                     296,308..313,315..316,362,371..373,386..401,403..415)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:381012"
     Site            order(248,304,377..385)
                     /site_type="other"
                     /note="trypsin binding site [polypeptide binding]"
                     /db_xref="CDD:381012"
     Site            368..393
                     /site_type="other"
                     /note="reactive center loop (RCL)"
                     /db_xref="CDD:381012"
     CDS             1..418
                     /gene="SERPINA1"
                     /gene_synonym="A1A; A1AT; AAT; alpha1AT; nNIF; PI; PI1;
                     PRO2275"
                     /coded_by="XM_017021370.2:423..1679"
                     /db_xref="GeneID:5265"
                     /db_xref="HGNC:HGNC:8941"
                     /db_xref="MIM:107400"
ORIGIN      
        1 mpssvswgil llaglcclvp vslaedpqgd aaqktdtshh dqdhptfnki tpnlaefafs
       61 lyrqlahqsn stniffspvs iatafamlsl gtkadthdei leglnfnlte ipeaqihegf
      121 qellrtlnqp dsqlqlttgn glflseglkl vdkfledvkk lyhseaftvn fgdteeakkq
      181 indyvekgtq gkivdlvkel drdtvfalvn yiffkgkwer pfevkdteee dfhvdqvttv
      241 kvpmmkrlgm fniqhckkls swvllmkylg nataifflpd egklqhlene lthdiitkfl
      301 enedrrsasl hlpklsitgt ydlksvlgql gitkvfsnga dlsgvteeap lklskavhka
      361 vltidekgte aagamfleai pmsippevkf nkpfvflmie qntksplfmg kvvnptqk
//
LOCUS       XP_047287437             479 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger FYVE domain-containing protein 1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_047287437
VERSION     XP_047287437.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431481.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..479
                     /product="zinc finger FYVE domain-containing protein 1
                     isoform X1"
                     /calculated_mol_wt=54089
     Region          16..63
                     /region_name="Bbox1_ZFYVE1_rpt1"
                     /note="first B-box-type 1 zinc finger found in zinc finger
                     FYVE domain-containing protein 1 (ZFYVE1) and similar
                     proteins; cd19819"
                     /db_xref="CDD:380877"
     Region          69..122
                     /region_name="Bbox1_ZFYVE1_rpt2"
                     /note="second B-box-type 1 zinc finger found in zinc
                     finger FYVE domain-containing protein 1 (ZFYVE1) and
                     similar proteins; cd19820"
                     /db_xref="CDD:380878"
     Region          174..410
                     /region_name="GBP"
                     /note="Guanylate-binding protein (GBP) family (N-terminal
                     domain); cd01851"
                     /db_xref="CDD:206650"
     Site            187..194
                     /site_type="other"
                     /note="G1 box"
                     /db_xref="CDD:206650"
     Site            order(189..195,210..212,217..218,238,331..332,376)
                     /site_type="other"
                     /note="GTP/Mg2+ binding site [chemical binding]"
                     /db_xref="CDD:206650"
     Site            order(207..212,217..224)
                     /site_type="other"
                     /note="Switch I region"
                     /db_xref="CDD:206650"
     Site            218
                     /site_type="other"
                     /note="G2 box"
                     /db_xref="CDD:206650"
     Site            235..238
                     /site_type="other"
                     /note="G3 box"
                     /db_xref="CDD:206650"
     Site            order(237..241,251..257,260..262)
                     /site_type="other"
                     /note="Switch II region"
                     /db_xref="CDD:206650"
     Site            331..334
                     /site_type="other"
                     /note="G4 box"
                     /db_xref="CDD:206650"
     Site            374..376
                     /site_type="other"
                     /note="G5 box"
                     /db_xref="CDD:206650"
     CDS             1..479
                     /gene="ZFYVE1"
                     /gene_synonym="DFCP1; PPP1R172; SR3; TAFF1; ZNFN2A1"
                     /coded_by="XM_047431481.1:616..2055"
                     /db_xref="GeneID:53349"
                     /db_xref="HGNC:HGNC:13180"
                     /db_xref="MIM:605471"
ORIGIN      
        1 msaqtspaek glnpglmcqe syacsgtdea ifecdeccsl qclrceeelh rqerlrnher
       61 irlkpghvpy cdlckglsgh lpgvrqraiv rcqtckinlc lecqkrthsg gnkrrhpvtv
      121 ynvsnlqesl eaeemdeetk rkkmtekvvs fllvdeneei qvtneedfir kldckpdqhl
      181 kvvsifgntg dgkshtlnht ffygrevfkt sptqesctvg vwaaydpvhk vavidtegll
      241 gatvnlsqrt rlllkvlais dlviyrthad rlhndlfkfl gdaseaylkh ftkelkatta
      301 rcgldvplst lgpaviifhe tvhtqllgsd hpsevpekli qdrfrklgrf peafssihyk
      361 gtrtynpptd fsglrraleq llennttrsp rhpgvifkal kalsdrfsge ipddqmahss
      421 ffpdeyftcs slclscgvgc kksmnhgkeg vpheaksrcr yshqydnrvy tckvcdrms
//
LOCUS       XP_047287438             362 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger FYVE domain-containing protein 1 isoform X2 [Homo
            sapiens].
ACCESSION   XP_047287438
VERSION     XP_047287438.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431482.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..362
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..362
                     /product="zinc finger FYVE domain-containing protein 1
                     isoform X2"
                     /calculated_mol_wt=40130
     Region          179..240
                     /region_name="FYVE_like_SF"
                     /note="FYVE domain like superfamily; cl28890"
                     /db_xref="CDD:333710"
     Site            order(201..206,211,234)
                     /site_type="other"
                     /note="phosphatidylinositol 3-phosphate binding site
                     [chemical binding]"
                     /db_xref="CDD:277249"
     Region          296..356
                     /region_name="FYVE_ZFYV1"
                     /note="FYVE domains found in zinc finger FYVE
                     domain-containing protein 1 (ZFYV1) and similar proteins;
                     cd15734"
                     /db_xref="CDD:277273"
     Site            order(297,300,318..323,325..326,350..352)
                     /site_type="other"
                     /note="putative phosphatidylinositol 3-phosphate binding
                     site [chemical binding]"
                     /db_xref="CDD:277273"
     CDS             1..362
                     /gene="ZFYVE1"
                     /gene_synonym="DFCP1; PPP1R172; SR3; TAFF1; ZNFN2A1"
                     /coded_by="XM_047431482.1:778..1866"
                     /db_xref="GeneID:53349"
                     /db_xref="HGNC:HGNC:13180"
                     /db_xref="MIM:605471"
ORIGIN      
        1 mahssffpde yftcsslcls cgvgckksmn hgkegvphea ksrcryshqy dnrvytckac
       61 yergeevsvv pktsastdsp wmglakyaws gyviecpncg vvyrsrqywf gnqdpvdtvv
      121 rteivhvwpg tdgflkdnnn aaqrlldgmn fmaqsvsels lgptkavtsw ltdqiapayw
      181 rpnsqilscn kcatsfkdnd tkhhcracge gfcdscsskt rpvpergwgp apvrvcdncy
      241 earnvqlavt eaqvddeggt liarkvgeav qntlgavvta idiplglvkd aarpaywvpd
      301 heilhchncr kefsiklskh hcracgqgfc decshdrrav psrgwdhpvr vcfncnkkpg
      361 dl
//
LOCUS       XP_016876862             362 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger FYVE domain-containing protein 1 isoform X2 [Homo
            sapiens].
ACCESSION   XP_016876862
VERSION     XP_016876862.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021373.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..362
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..362
                     /product="zinc finger FYVE domain-containing protein 1
                     isoform X2"
                     /calculated_mol_wt=40130
     Region          179..240
                     /region_name="FYVE_like_SF"
                     /note="FYVE domain like superfamily; cl28890"
                     /db_xref="CDD:333710"
     Site            order(201..206,211,234)
                     /site_type="other"
                     /note="phosphatidylinositol 3-phosphate binding site
                     [chemical binding]"
                     /db_xref="CDD:277249"
     Region          296..356
                     /region_name="FYVE_ZFYV1"
                     /note="FYVE domains found in zinc finger FYVE
                     domain-containing protein 1 (ZFYV1) and similar proteins;
                     cd15734"
                     /db_xref="CDD:277273"
     Site            order(297,300,318..323,325..326,350..352)
                     /site_type="other"
                     /note="putative phosphatidylinositol 3-phosphate binding
                     site [chemical binding]"
                     /db_xref="CDD:277273"
     CDS             1..362
                     /gene="ZFYVE1"
                     /gene_synonym="DFCP1; PPP1R172; SR3; TAFF1; ZNFN2A1"
                     /coded_by="XM_017021373.2:639..1727"
                     /db_xref="GeneID:53349"
                     /db_xref="HGNC:HGNC:13180"
                     /db_xref="MIM:605471"
ORIGIN      
        1 mahssffpde yftcsslcls cgvgckksmn hgkegvphea ksrcryshqy dnrvytckac
       61 yergeevsvv pktsastdsp wmglakyaws gyviecpncg vvyrsrqywf gnqdpvdtvv
      121 rteivhvwpg tdgflkdnnn aaqrlldgmn fmaqsvsels lgptkavtsw ltdqiapayw
      181 rpnsqilscn kcatsfkdnd tkhhcracge gfcdscsskt rpvpergwgp apvrvcdncy
      241 earnvqlavt eaqvddeggt liarkvgeav qntlgavvta idiplglvkd aarpaywvpd
      301 heilhchncr kefsiklskh hcracgqgfc decshdrrav psrgwdhpvr vcfncnkkpg
      361 dl
//
LOCUS       XP_047287439             400 aa            linear   PRI 05-AUG-2025
DEFINITION  DNA polymerase epsilon subunit 2 isoform X1 [Homo sapiens].
ACCESSION   XP_047287439
VERSION     XP_047287439.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431483.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..400
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..400
                     /product="DNA polymerase epsilon subunit 2 isoform X1"
                     /calculated_mol_wt=44986
     Region          2..74
                     /region_name="Dpoe2NT"
                     /note="DNA polymerases epsilon N terminal; pfam12213"
                     /db_xref="CDD:463494"
     Region          287..>329
                     /region_name="DNA_pol_E_B"
                     /note="DNA polymerase alpha/epsilon subunit B; pfam04042"
                     /db_xref="CDD:461142"
     CDS             1..400
                     /gene="POLE2"
                     /gene_synonym="DPE2"
                     /coded_by="XM_047431483.1:12..1214"
                     /db_xref="GeneID:5427"
                     /db_xref="HGNC:HGNC:9178"
                     /db_xref="MIM:602670"
ORIGIN      
        1 maperlrsra lsafklrgll lrgeaikylt ealqsisele ledklekiin avekqplssn
       61 miersvveaa vqecsqsvde tiehvfniig afdiprfvyn serkkflpll mtnhpapnlf
      121 gtprdkaemf rerytilhqr thrhelftpp vigshpdesg skfqlktiet llgsttkigd
      181 aivlgmitql kegkffledp tgtvqldlsk aqfhsglyte acfvlaegwf edqvfhvnaf
      241 gfpptepsst trayygninf fggpsntsvk tsaklkqlee enkdamfvfl sdvwldqvev
      301 leklrimfag yspapptcfi lcgnfssapy gknqvqalkv vvlclylvqr ildlvpsyqg
      361 hhllkaslmn sdkgyhfqfl llilaefstv hrkllssvkt
//
LOCUS       XP_047287440             265 aa            linear   PRI 05-AUG-2025
DEFINITION  DNA polymerase epsilon subunit 2 isoform X2 [Homo sapiens].
ACCESSION   XP_047287440
VERSION     XP_047287440.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431484.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..265
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..265
                     /product="DNA polymerase epsilon subunit 2 isoform X2"
                     /calculated_mol_wt=29862
     Region          2..74
                     /region_name="Dpoe2NT"
                     /note="DNA polymerases epsilon N terminal; pfam12213"
                     /db_xref="CDD:463494"
     CDS             1..265
                     /gene="POLE2"
                     /gene_synonym="DPE2"
                     /coded_by="XM_047431484.1:12..809"
                     /db_xref="GeneID:5427"
                     /db_xref="HGNC:HGNC:9178"
                     /db_xref="MIM:602670"
ORIGIN      
        1 maperlrsra lsafklrgll lrgeaikylt ealqsisele ledklekiin avekqplssn
       61 miersvveaa vqecsqsvde tiehvfniig afdiprfvyn serkkflpll mtnhpapnlf
      121 gtprdkaemf rerytilhqr thrhelftpp vigshpdesg skfqlktiet llgsttkigd
      181 aivlgmitql kegkffledp tgtvqldlsk aqfhsglyte acfvlaegwf edqvfhvnaf
      241 gfpptepsst trlftstsnl lysvw
//
LOCUS       XP_047287441              81 aa            linear   PRI 05-AUG-2025
DEFINITION  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
            isoform X1 [Homo sapiens].
ACCESSION   XP_047287441
VERSION     XP_047287441.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431485.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..81
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..81
                     /product="guanine nucleotide-binding protein
                     G(I)/G(S)/G(O) subunit gamma-2 isoform X1"
                     /calculated_mol_wt=8839
     Region          19..81
                     /region_name="GGL"
                     /note="G protein gamma subunit-like motifs; smart00224"
                     /db_xref="CDD:128520"
     Site            order(19,22,26,29,33,38,40,43..44,47..48,51,60..61,71)
                     /site_type="other"
                     /note="beta subunit binding site [polypeptide binding]"
                     /db_xref="CDD:238024"
     CDS             1..81
                     /gene="GNG2"
                     /gene_synonym="HG3F1"
                     /coded_by="XM_047431485.1:1126..1371"
                     /db_xref="GeneID:54331"
                     /db_xref="HGNC:HGNC:4404"
                     /db_xref="MIM:606981"
ORIGIN      
        1 mflkdlsstp masnntasia qarklveqlk meanidrikv skaaadlmay ceahakedpl
       61 ltpvpasenp frekkffcai l
//
LOCUS       XP_047287442              71 aa            linear   PRI 05-AUG-2025
DEFINITION  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
            isoform X2 [Homo sapiens].
ACCESSION   XP_047287442
VERSION     XP_047287442.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431486.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..71
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..71
                     /product="guanine nucleotide-binding protein
                     G(I)/G(S)/G(O) subunit gamma-2 isoform X2"
                     /calculated_mol_wt=7719
     Region          9..71
                     /region_name="GGL"
                     /note="G protein gamma subunit-like motifs; smart00224"
                     /db_xref="CDD:128520"
     Site            order(9,12,16,19,23,28,30,33..34,37..38,41,50..51,61)
                     /site_type="other"
                     /note="beta subunit binding site [polypeptide binding]"
                     /db_xref="CDD:238024"
     CDS             1..71
                     /gene="GNG2"
                     /gene_synonym="HG3F1"
                     /coded_by="XM_047431486.1:1878..2093"
                     /db_xref="GeneID:54331"
                     /db_xref="HGNC:HGNC:4404"
                     /db_xref="MIM:606981"
ORIGIN      
        1 masnntasia qarklveqlk meanidrikv skaaadlmay ceahakedpl ltpvpasenp
       61 frekkffcai l
//
LOCUS       XP_047287443              71 aa            linear   PRI 05-AUG-2025
DEFINITION  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
            isoform X2 [Homo sapiens].
ACCESSION   XP_047287443
VERSION     XP_047287443.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431487.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..71
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..71
                     /product="guanine nucleotide-binding protein
                     G(I)/G(S)/G(O) subunit gamma-2 isoform X2"
                     /calculated_mol_wt=7719
     Region          9..71
                     /region_name="GGL"
                     /note="G protein gamma subunit-like motifs; smart00224"
                     /db_xref="CDD:128520"
     Site            order(9,12,16,19,23,28,30,33..34,37..38,41,50..51,61)
                     /site_type="other"
                     /note="beta subunit binding site [polypeptide binding]"
                     /db_xref="CDD:238024"
     CDS             1..71
                     /gene="GNG2"
                     /gene_synonym="HG3F1"
                     /coded_by="XM_047431487.1:3122..3337"
                     /db_xref="GeneID:54331"
                     /db_xref="HGNC:HGNC:4404"
                     /db_xref="MIM:606981"
ORIGIN      
        1 masnntasia qarklveqlk meanidrikv skaaadlmay ceahakedpl ltpvpasenp
       61 frekkffcai l
//
LOCUS       XP_047287444              71 aa            linear   PRI 05-AUG-2025
DEFINITION  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
            isoform X2 [Homo sapiens].
ACCESSION   XP_047287444
VERSION     XP_047287444.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431488.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..71
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..71
                     /product="guanine nucleotide-binding protein
                     G(I)/G(S)/G(O) subunit gamma-2 isoform X2"
                     /calculated_mol_wt=7719
     Region          9..71
                     /region_name="GGL"
                     /note="G protein gamma subunit-like motifs; smart00224"
                     /db_xref="CDD:128520"
     Site            order(9,12,16,19,23,28,30,33..34,37..38,41,50..51,61)
                     /site_type="other"
                     /note="beta subunit binding site [polypeptide binding]"
                     /db_xref="CDD:238024"
     CDS             1..71
                     /gene="GNG2"
                     /gene_synonym="HG3F1"
                     /coded_by="XM_047431488.1:3433..3648"
                     /db_xref="GeneID:54331"
                     /db_xref="HGNC:HGNC:4404"
                     /db_xref="MIM:606981"
ORIGIN      
        1 masnntasia qarklveqlk meanidrikv skaaadlmay ceahakedpl ltpvpasenp
       61 frekkffcai l
//
LOCUS       XP_024305401              71 aa            linear   PRI 05-AUG-2025
DEFINITION  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
            isoform X2 [Homo sapiens].
ACCESSION   XP_024305401
VERSION     XP_024305401.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449633.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..71
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..71
                     /product="guanine nucleotide-binding protein
                     G(I)/G(S)/G(O) subunit gamma-2 isoform X2"
                     /calculated_mol_wt=7719
     Region          9..71
                     /region_name="GGL"
                     /note="G protein gamma subunit-like motifs; smart00224"
                     /db_xref="CDD:128520"
     Site            order(9,12,16,19,23,28,30,33..34,37..38,41,50..51,61)
                     /site_type="other"
                     /note="beta subunit binding site [polypeptide binding]"
                     /db_xref="CDD:238024"
     CDS             1..71
                     /gene="GNG2"
                     /gene_synonym="HG3F1"
                     /coded_by="XM_024449633.2:598..813"
                     /db_xref="GeneID:54331"
                     /db_xref="HGNC:HGNC:4404"
                     /db_xref="MIM:606981"
ORIGIN      
        1 masnntasia qarklveqlk meanidrikv skaaadlmay ceahakedpl ltpvpasenp
       61 frekkffcai l
//
LOCUS       XP_016876866              71 aa            linear   PRI 05-AUG-2025
DEFINITION  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
            isoform X2 [Homo sapiens].
ACCESSION   XP_016876866
VERSION     XP_016876866.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021377.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..71
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..71
                     /product="guanine nucleotide-binding protein
                     G(I)/G(S)/G(O) subunit gamma-2 isoform X2"
                     /calculated_mol_wt=7719
     Region          9..71
                     /region_name="GGL"
                     /note="G protein gamma subunit-like motifs; smart00224"
                     /db_xref="CDD:128520"
     Site            order(9,12,16,19,23,28,30,33..34,37..38,41,50..51,61)
                     /site_type="other"
                     /note="beta subunit binding site [polypeptide binding]"
                     /db_xref="CDD:238024"
     CDS             1..71
                     /gene="GNG2"
                     /gene_synonym="HG3F1"
                     /coded_by="XM_017021377.2:799..1014"
                     /db_xref="GeneID:54331"
                     /db_xref="HGNC:HGNC:4404"
                     /db_xref="MIM:606981"
ORIGIN      
        1 masnntasia qarklveqlk meanidrikv skaaadlmay ceahakedpl ltpvpasenp
       61 frekkffcai l
//
LOCUS       XP_047287446              71 aa            linear   PRI 05-AUG-2025
DEFINITION  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
            isoform X2 [Homo sapiens].
ACCESSION   XP_047287446
VERSION     XP_047287446.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431490.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..71
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..71
                     /product="guanine nucleotide-binding protein
                     G(I)/G(S)/G(O) subunit gamma-2 isoform X2"
                     /calculated_mol_wt=7719
     Region          9..71
                     /region_name="GGL"
                     /note="G protein gamma subunit-like motifs; smart00224"
                     /db_xref="CDD:128520"
     Site            order(9,12,16,19,23,28,30,33..34,37..38,41,50..51,61)
                     /site_type="other"
                     /note="beta subunit binding site [polypeptide binding]"
                     /db_xref="CDD:238024"
     CDS             1..71
                     /gene="GNG2"
                     /gene_synonym="HG3F1"
                     /coded_by="XM_047431490.1:502..717"
                     /db_xref="GeneID:54331"
                     /db_xref="HGNC:HGNC:4404"
                     /db_xref="MIM:606981"
ORIGIN      
        1 masnntasia qarklveqlk meanidrikv skaaadlmay ceahakedpl ltpvpasenp
       61 frekkffcai l
//
LOCUS       XP_024305402              71 aa            linear   PRI 05-AUG-2025
DEFINITION  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
            isoform X2 [Homo sapiens].
ACCESSION   XP_024305402
VERSION     XP_024305402.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449634.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..71
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..71
                     /product="guanine nucleotide-binding protein
                     G(I)/G(S)/G(O) subunit gamma-2 isoform X2"
                     /calculated_mol_wt=7719
     Region          9..71
                     /region_name="GGL"
                     /note="G protein gamma subunit-like motifs; smart00224"
                     /db_xref="CDD:128520"
     Site            order(9,12,16,19,23,28,30,33..34,37..38,41,50..51,61)
                     /site_type="other"
                     /note="beta subunit binding site [polypeptide binding]"
                     /db_xref="CDD:238024"
     CDS             1..71
                     /gene="GNG2"
                     /gene_synonym="HG3F1"
                     /coded_by="XM_024449634.2:246..461"
                     /db_xref="GeneID:54331"
                     /db_xref="HGNC:HGNC:4404"
                     /db_xref="MIM:606981"
ORIGIN      
        1 masnntasia qarklveqlk meanidrikv skaaadlmay ceahakedpl ltpvpasenp
       61 frekkffcai l
//
LOCUS       XP_005267827             571 aa            linear   PRI 05-AUG-2025
DEFINITION  kelch-like protein 28 isoform X1 [Homo sapiens].
ACCESSION   XP_005267827
VERSION     XP_005267827.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267770.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..571
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..571
                     /product="kelch-like protein 28 isoform X1"
                     /calculated_mol_wt=64061
     Region          35..553
                     /region_name="PHA03098"
                     /note="kelch-like protein; Provisional"
                     /db_xref="CDD:222983"
     Region          321..372
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          376..419
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          423..465
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          469..513
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          516..559
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     CDS             1..571
                     /gene="KLHL28"
                     /gene_synonym="BTBD5"
                     /coded_by="XM_005267770.5:352..2067"
                     /db_xref="GeneID:54813"
                     /db_xref="HGNC:HGNC:19741"
ORIGIN      
        1 mdhtsptyml anlthlhseq llqglnllrq hhelcdiilr vgdvkihahk vvlasvspyf
       61 kamftgnlse kensevefqc idetalqaiv eyaytgtvfi sqdtvesllp aanllqiklv
      121 lkeccafles qldpgncigi srfaetygcr dlylaatkyi cqnfeavcqt eeffelthad
      181 ldeivsndcl nvateetvfy aleswikydv qerqkylaql lnsvrlplls vkfltrlyea
      241 nhlirddrtc khllnealky hfmpehrlsh qtvlmtrprc apkvlcavgg ksglfaclds
      301 vemyfpqnds wiglaplnip ryefgicvld qkvyviggia tnvrpgvtir khensvecwn
      361 pdtntwtsle rmnesrstlg vvvlagelya lggydgqsyl qsvekyipki rkwqpvapmt
      421 ttrscfaaav ldgmiyaigg ygpahmnsve rydpskdswe mvasmadkri hfgvgvmlgf
      481 ifvvgghngv shlssieryd phqnqwtvcr pmkeprtgvg aavidnylyv vgghsgssyl
      541 ntvqkydpis dtwldsagmi ycrcnfglta l
//
LOCUS       XP_011535149             571 aa            linear   PRI 05-AUG-2025
DEFINITION  kelch-like protein 28 isoform X1 [Homo sapiens].
ACCESSION   XP_011535149
VERSION     XP_011535149.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536847.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..571
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..571
                     /product="kelch-like protein 28 isoform X1"
                     /calculated_mol_wt=64061
     Region          35..553
                     /region_name="PHA03098"
                     /note="kelch-like protein; Provisional"
                     /db_xref="CDD:222983"
     Region          321..372
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          376..419
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          423..465
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          469..513
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          516..559
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     CDS             1..571
                     /gene="KLHL28"
                     /gene_synonym="BTBD5"
                     /coded_by="XM_011536847.4:190..1905"
                     /db_xref="GeneID:54813"
                     /db_xref="HGNC:HGNC:19741"
ORIGIN      
        1 mdhtsptyml anlthlhseq llqglnllrq hhelcdiilr vgdvkihahk vvlasvspyf
       61 kamftgnlse kensevefqc idetalqaiv eyaytgtvfi sqdtvesllp aanllqiklv
      121 lkeccafles qldpgncigi srfaetygcr dlylaatkyi cqnfeavcqt eeffelthad
      181 ldeivsndcl nvateetvfy aleswikydv qerqkylaql lnsvrlplls vkfltrlyea
      241 nhlirddrtc khllnealky hfmpehrlsh qtvlmtrprc apkvlcavgg ksglfaclds
      301 vemyfpqnds wiglaplnip ryefgicvld qkvyviggia tnvrpgvtir khensvecwn
      361 pdtntwtsle rmnesrstlg vvvlagelya lggydgqsyl qsvekyipki rkwqpvapmt
      421 ttrscfaaav ldgmiyaigg ygpahmnsve rydpskdswe mvasmadkri hfgvgvmlgf
      481 ifvvgghngv shlssieryd phqnqwtvcr pmkeprtgvg aavidnylyv vgghsgssyl
      541 ntvqkydpis dtwldsagmi ycrcnfglta l
//
LOCUS       XP_047287447             571 aa            linear   PRI 05-AUG-2025
DEFINITION  kelch-like protein 28 isoform X1 [Homo sapiens].
ACCESSION   XP_047287447
VERSION     XP_047287447.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431491.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..571
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..571
                     /product="kelch-like protein 28 isoform X1"
                     /calculated_mol_wt=64061
     Region          35..553
                     /region_name="PHA03098"
                     /note="kelch-like protein; Provisional"
                     /db_xref="CDD:222983"
     Region          321..372
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          376..419
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          423..465
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          469..513
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          516..559
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     CDS             1..571
                     /gene="KLHL28"
                     /gene_synonym="BTBD5"
                     /coded_by="XM_047431491.1:687..2402"
                     /db_xref="GeneID:54813"
                     /db_xref="HGNC:HGNC:19741"
ORIGIN      
        1 mdhtsptyml anlthlhseq llqglnllrq hhelcdiilr vgdvkihahk vvlasvspyf
       61 kamftgnlse kensevefqc idetalqaiv eyaytgtvfi sqdtvesllp aanllqiklv
      121 lkeccafles qldpgncigi srfaetygcr dlylaatkyi cqnfeavcqt eeffelthad
      181 ldeivsndcl nvateetvfy aleswikydv qerqkylaql lnsvrlplls vkfltrlyea
      241 nhlirddrtc khllnealky hfmpehrlsh qtvlmtrprc apkvlcavgg ksglfaclds
      301 vemyfpqnds wiglaplnip ryefgicvld qkvyviggia tnvrpgvtir khensvecwn
      361 pdtntwtsle rmnesrstlg vvvlagelya lggydgqsyl qsvekyipki rkwqpvapmt
      421 ttrscfaaav ldgmiyaigg ygpahmnsve rydpskdswe mvasmadkri hfgvgvmlgf
      481 ifvvgghngv shlssieryd phqnqwtvcr pmkeprtgvg aavidnylyv vgghsgssyl
      541 ntvqkydpis dtwldsagmi ycrcnfglta l
//
LOCUS       XP_011535151             469 aa            linear   PRI 05-AUG-2025
DEFINITION  kelch-like protein 28 isoform X2 [Homo sapiens].
ACCESSION   XP_011535151
VERSION     XP_011535151.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536849.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..469
                     /product="kelch-like protein 28 isoform X2"
                     /calculated_mol_wt=53084
     Region          31..148
                     /region_name="BTB_POZ_KLHL28_BTBD5"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in Kelch-like
                     protein 28 (KLHL28); cd18257"
                     /db_xref="CDD:349566"
     Region          49..455
                     /region_name="PHA03098"
                     /note="kelch-like protein; Provisional"
                     /db_xref="CDD:222983"
     Region          146..244
                     /region_name="BACK"
                     /note="BACK (BTB and C-terminal Kelch) domain; cl28903"
                     /db_xref="CDD:475122"
     Region          335..386
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          390..434
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     CDS             1..469
                     /gene="KLHL28"
                     /gene_synonym="BTBD5"
                     /coded_by="XM_011536849.3:558..1967"
                     /db_xref="GeneID:54813"
                     /db_xref="HGNC:HGNC:19741"
ORIGIN      
        1 mhfkckysyp alyqmdhtsp tymlanlthl hseqllqgln llrqhhelcd iilrvgdvki
       61 hahkvvlasv spyfkamftg nlsekensev efqcidetal qaiveyaytg tvfisqdtve
      121 sllpaanllq iklvlkecca flesqldpgn cigisrfaet ygcrdlylaa tkyicqnfea
      181 vcqteeffel thadldeivs ndclnvatee tvfyaleswi kydvqerqky laqllnsvrl
      241 pllsvkfltr lyeanhlird drtckhllne alkyhfmpeh rlshqtvlmt rprcapkvlc
      301 avggksglfa cldsvemyfp qndswiglap lnipryefgi cvldqkvyvi ggiatnvrpg
      361 vtirkhensv ecwnpdtntw tslermnesr stlgvvvlag elyalggydg qsylqsveky
      421 ipkirkwqpv apmtttrscf aaavldgmiy aiggygpahm nrswcccnr
//
LOCUS       XP_024305403             455 aa            linear   PRI 05-AUG-2025
DEFINITION  kelch-like protein 28 isoform X3 [Homo sapiens].
ACCESSION   XP_024305403
VERSION     XP_024305403.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449635.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..455
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..455
                     /product="kelch-like protein 28 isoform X3"
                     /calculated_mol_wt=51323
     Region          17..134
                     /region_name="BTB_POZ_KLHL28_BTBD5"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in Kelch-like
                     protein 28 (KLHL28); cd18257"
                     /db_xref="CDD:349566"
     Region          35..441
                     /region_name="PHA03098"
                     /note="kelch-like protein; Provisional"
                     /db_xref="CDD:222983"
     Region          132..230
                     /region_name="BACK"
                     /note="BACK (BTB and C-terminal Kelch) domain; cl28903"
                     /db_xref="CDD:475122"
     Region          321..372
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          376..420
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     CDS             1..455
                     /gene="KLHL28"
                     /gene_synonym="BTBD5"
                     /coded_by="XM_024449635.2:103..1470"
                     /db_xref="GeneID:54813"
                     /db_xref="HGNC:HGNC:19741"
ORIGIN      
        1 mdhtsptyml anlthlhseq llqglnllrq hhelcdiilr vgdvkihahk vvlasvspyf
       61 kamftgnlse kensevefqc idetalqaiv eyaytgtvfi sqdtvesllp aanllqiklv
      121 lkeccafles qldpgncigi srfaetygcr dlylaatkyi cqnfeavcqt eeffelthad
      181 ldeivsndcl nvateetvfy aleswikydv qerqkylaql lnsvrlplls vkfltrlyea
      241 nhlirddrtc khllnealky hfmpehrlsh qtvlmtrprc apkvlcavgg ksglfaclds
      301 vemyfpqnds wiglaplnip ryefgicvld qkvyviggia tnvrpgvtir khensvecwn
      361 pdtntwtsle rmnesrstlg vvvlagelya lggydgqsyl qsvekyipki rkwqpvapmt
      421 ttrscfaaav ldgmiyaigg ygpahmnrsw cccnr
//
LOCUS       XP_006720237             332 aa            linear   PRI 05-AUG-2025
DEFINITION  kelch-like protein 28 isoform X4 [Homo sapiens].
ACCESSION   XP_006720237
VERSION     XP_006720237.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720174.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..332
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..332
                     /product="kelch-like protein 28 isoform X4"
                     /calculated_mol_wt=37939
     Region          31..148
                     /region_name="BTB_POZ_KLHL28_BTBD5"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in Kelch-like
                     protein 28 (KLHL28); cd18257"
                     /db_xref="CDD:349566"
     Region          146..244
                     /region_name="BACK"
                     /note="BACK (BTB and C-terminal Kelch) domain; cl28903"
                     /db_xref="CDD:475122"
     CDS             1..332
                     /gene="KLHL28"
                     /gene_synonym="BTBD5"
                     /coded_by="XM_006720174.4:558..1556"
                     /db_xref="GeneID:54813"
                     /db_xref="HGNC:HGNC:19741"
ORIGIN      
        1 mhfkckysyp alyqmdhtsp tymlanlthl hseqllqgln llrqhhelcd iilrvgdvki
       61 hahkvvlasv spyfkamftg nlsekensev efqcidetal qaiveyaytg tvfisqdtve
      121 sllpaanllq iklvlkecca flesqldpgn cigisrfaet ygcrdlylaa tkyicqnfea
      181 vcqteeffel thadldeivs ndclnvatee tvfyaleswi kydvqerqky laqllnsvrl
      241 pllsvkfltr lyeanhlird drtckhllne alkyhfmpeh rlshqtvlmt rprcapkvlc
      301 avggksglfa cldrlasypc dvfyhemtlp rc
//
LOCUS       XP_016876867             318 aa            linear   PRI 05-AUG-2025
DEFINITION  kelch-like protein 28 isoform X5 [Homo sapiens].
ACCESSION   XP_016876867
VERSION     XP_016876867.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021378.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..318
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..318
                     /product="kelch-like protein 28 isoform X5"
                     /calculated_mol_wt=36178
     Region          17..134
                     /region_name="BTB_POZ_KLHL28_BTBD5"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in Kelch-like
                     protein 28 (KLHL28); cd18257"
                     /db_xref="CDD:349566"
     Region          132..230
                     /region_name="BACK"
                     /note="BACK (BTB and C-terminal Kelch) domain; cl28903"
                     /db_xref="CDD:475122"
     CDS             1..318
                     /gene="KLHL28"
                     /gene_synonym="BTBD5"
                     /coded_by="XM_017021378.2:103..1059"
                     /db_xref="GeneID:54813"
                     /db_xref="HGNC:HGNC:19741"
ORIGIN      
        1 mdhtsptyml anlthlhseq llqglnllrq hhelcdiilr vgdvkihahk vvlasvspyf
       61 kamftgnlse kensevefqc idetalqaiv eyaytgtvfi sqdtvesllp aanllqiklv
      121 lkeccafles qldpgncigi srfaetygcr dlylaatkyi cqnfeavcqt eeffelthad
      181 ldeivsndcl nvateetvfy aleswikydv qerqkylaql lnsvrlplls vkfltrlyea
      241 nhlirddrtc khllnealky hfmpehrlsh qtvlmtrprc apkvlcavgg ksglfacldr
      301 lasypcdvfy hemtlprc
//
LOCUS       XP_047287448             318 aa            linear   PRI 05-AUG-2025
DEFINITION  kelch-like protein 28 isoform X5 [Homo sapiens].
ACCESSION   XP_047287448
VERSION     XP_047287448.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431492.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..318
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..318
                     /product="kelch-like protein 28 isoform X5"
                     /calculated_mol_wt=36178
     Region          17..134
                     /region_name="BTB_POZ_KLHL28_BTBD5"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in Kelch-like
                     protein 28 (KLHL28); cd18257"
                     /db_xref="CDD:349566"
     Region          132..230
                     /region_name="BACK"
                     /note="BACK (BTB and C-terminal Kelch) domain; cl28903"
                     /db_xref="CDD:475122"
     CDS             1..318
                     /gene="KLHL28"
                     /gene_synonym="BTBD5"
                     /coded_by="XM_047431492.1:352..1308"
                     /db_xref="GeneID:54813"
                     /db_xref="HGNC:HGNC:19741"
ORIGIN      
        1 mdhtsptyml anlthlhseq llqglnllrq hhelcdiilr vgdvkihahk vvlasvspyf
       61 kamftgnlse kensevefqc idetalqaiv eyaytgtvfi sqdtvesllp aanllqiklv
      121 lkeccafles qldpgncigi srfaetygcr dlylaatkyi cqnfeavcqt eeffelthad
      181 ldeivsndcl nvateetvfy aleswikydv qerqkylaql lnsvrlplls vkfltrlyea
      241 nhlirddrtc khllnealky hfmpehrlsh qtvlmtrprc apkvlcavgg ksglfacldr
      301 lasypcdvfy hemtlprc
//
LOCUS       XP_011535153             636 aa            linear   PRI 05-AUG-2025
DEFINITION  protein O-mannosyl-transferase TMEM260 isoform X1 [Homo sapiens].
ACCESSION   XP_011535153
VERSION     XP_011535153.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536851.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..636
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..636
                     /product="protein O-mannosyl-transferase TMEM260 isoform
                     X1"
                     /calculated_mol_wt=70855
     Region          52..206
                     /region_name="DUF2723"
                     /note="Protein of unknown function (DUF2723); pfam11028"
                     /db_xref="CDD:463208"
     CDS             1..636
                     /gene="TMEM260"
                     /gene_synonym="C14orf101; SHDRA"
                     /coded_by="XM_011536851.3:118..2028"
                     /db_xref="GeneID:54916"
                     /db_xref="HGNC:HGNC:20185"
                     /db_xref="MIM:617449"
ORIGIN      
        1 msphgdgrgq aqgravrvgl rrsggirggv avfaavaavf tftlppsvpg gdsgelitaa
       61 helgvahppg yplftlvakl aitlfpfgsi ayrvnllcgl fgavaasllf ftvfrlsgss
      121 aggilaagvf sfsrltwqws iaaevfslnn lfvgllmalt vhfeeaatak erskvakiga
      181 fccglslcnq htiilyvlci ipwilfqllk kkelslgsll klslyfsagl lpyvhlpiss
      241 ylnharwtwg dqttlqgflt hflreeygtf slakseigss mseillsqvt nmrtelsfni
      301 qalavcanic latkdrqnps lvwlftgmfc iyslffawra nldiskplfm gvverfwmqs
      361 navvavlagi glaavvsetn rvlnsnglqc lewlsatlfv vyqiysnysv cdqrtnyvid
      421 kfaknlltsm phdaiillrg dlpgnslrym hyceglrpdi slvdqemmty ewylpkmakh
      481 lpgvnfpgnr wnpvegilps gmvtfnlyhf levnkqketf vcigihegdp twkknyslwp
      541 wgscdklvpl eivfnpeewi kltksiynwt eeygrfdpss wesvaneemw qarmktpffi
      601 fnlaetahmp skvkaqlyaq aydctdsiks dkrgfl
//
LOCUS       XP_011535154             590 aa            linear   PRI 05-AUG-2025
DEFINITION  protein O-mannosyl-transferase TMEM260 isoform X2 [Homo sapiens].
ACCESSION   XP_011535154
VERSION     XP_011535154.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536852.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..590
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..590
                     /product="protein O-mannosyl-transferase TMEM260 isoform
                     X2"
                     /calculated_mol_wt=67805
     CDS             1..590
                     /gene="TMEM260"
                     /gene_synonym="C14orf101; SHDRA"
                     /coded_by="XM_011536852.2:113..1885"
                     /db_xref="GeneID:54916"
                     /db_xref="HGNC:HGNC:20185"
                     /db_xref="MIM:617449"
ORIGIN      
        1 mqsvpflgil sgshefcgpr kedsyglsre fccshlmlns itssllqwri svicmiwvak
       61 igafccglsl cnqhtiilyv lciipwilfq llkkkelslg sllklslyfs agllpyvhlp
      121 issylnharw twgdqttlqg flthflreey gtfslaksei gssmseills qvtnmrtels
      181 fniqalavca niclatkdrq npslvwlftg mfciyslffa wranldiskp lfmgvverfw
      241 mqsnavvavl agiglaavvs etnrvlnsng lqclewlsat lfvvyqiysn ysvcdqrtny
      301 vidkfaknll tsmphdaiil lrgdlpgnsl rymhyceglr pdislvdqem mtyewylpkm
      361 akhlpgvnfp gnrwnpvegi lpsgmvtfnl yhflevnkqk etfvcigihe gdptwkknys
      421 lwpwgscdkl vpleivfnpe ewikltksiy nwteeygrfd psswesvane emwqarmktp
      481 ffifnlaeta hmpskvkaql yaqaydlyke ivylqkehpv nwhknyaiac ermlrlqard
      541 adpevllset irhfrlysqk apndpqqadi lgalkhlrke lqslrnrknv
//
LOCUS       XP_047287449             551 aa            linear   PRI 05-AUG-2025
DEFINITION  protein O-mannosyl-transferase TMEM260 isoform X3 [Homo sapiens].
ACCESSION   XP_047287449
VERSION     XP_047287449.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431493.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..551
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..551
                     /product="protein O-mannosyl-transferase TMEM260 isoform
                     X3"
                     /calculated_mol_wt=63329
     Region          <1..50
                     /region_name="DUF2723"
                     /note="Protein of unknown function (DUF2723); pfam11028"
                     /db_xref="CDD:463208"
     CDS             1..551
                     /gene="TMEM260"
                     /gene_synonym="C14orf101; SHDRA"
                     /coded_by="XM_047431493.1:408..2063"
                     /db_xref="GeneID:54916"
                     /db_xref="HGNC:HGNC:20185"
                     /db_xref="MIM:617449"
ORIGIN      
        1 maltvhfeea atakerskva kigafccgls lcnqhtiily vlciipwilf qllkkkelsl
       61 gsllklslyf sagllpyvhl pissylnhar wtwgdqttlq gflthflree ygtfslakse
      121 igssmseill sqvtnmrtel sfniqalavc aniclatkdr qnpslvwlft gmfciyslff
      181 awranldisk plfmgvverf wmqsnavvav lagiglaavv setnrvlnsn glqclewlsa
      241 tlfvvyqiys nysvcdqrtn yvidkfaknl ltsmphdaii llrgdlpgns lrymhycegl
      301 rpdislvdqe mmtyewylpk makhlpgvnf pgnrwnpveg ilpsgmvtfn lyhflevnkq
      361 ketfvcigih egdptwkkny slwpwgscdk lvpleivfnp eewikltksi ynwteeygrf
      421 dpsswesvan eemwqarmkt pffifnlaet ahmpskvkaq lyaqaydlyk eivylqkehp
      481 vnwhknyaia cermlrlqar dadpevllse tirhfrlysq kapndpqqad ilgalkhlrk
      541 elqslrnrkn v
//
LOCUS       XP_047287450             551 aa            linear   PRI 05-AUG-2025
DEFINITION  protein O-mannosyl-transferase TMEM260 isoform X3 [Homo sapiens].
ACCESSION   XP_047287450
VERSION     XP_047287450.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431494.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..551
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..551
                     /product="protein O-mannosyl-transferase TMEM260 isoform
                     X3"
                     /calculated_mol_wt=63329
     Region          <1..50
                     /region_name="DUF2723"
                     /note="Protein of unknown function (DUF2723); pfam11028"
                     /db_xref="CDD:463208"
     CDS             1..551
                     /gene="TMEM260"
                     /gene_synonym="C14orf101; SHDRA"
                     /coded_by="XM_047431494.1:384..2039"
                     /db_xref="GeneID:54916"
                     /db_xref="HGNC:HGNC:20185"
                     /db_xref="MIM:617449"
ORIGIN      
        1 maltvhfeea atakerskva kigafccgls lcnqhtiily vlciipwilf qllkkkelsl
       61 gsllklslyf sagllpyvhl pissylnhar wtwgdqttlq gflthflree ygtfslakse
      121 igssmseill sqvtnmrtel sfniqalavc aniclatkdr qnpslvwlft gmfciyslff
      181 awranldisk plfmgvverf wmqsnavvav lagiglaavv setnrvlnsn glqclewlsa
      241 tlfvvyqiys nysvcdqrtn yvidkfaknl ltsmphdaii llrgdlpgns lrymhycegl
      301 rpdislvdqe mmtyewylpk makhlpgvnf pgnrwnpveg ilpsgmvtfn lyhflevnkq
      361 ketfvcigih egdptwkkny slwpwgscdk lvpleivfnp eewikltksi ynwteeygrf
      421 dpsswesvan eemwqarmkt pffifnlaet ahmpskvkaq lyaqaydlyk eivylqkehp
      481 vnwhknyaia cermlrlqar dadpevllse tirhfrlysq kapndpqqad ilgalkhlrk
      541 elqslrnrkn v
//
LOCUS       XP_047287451             441 aa            linear   PRI 05-AUG-2025
DEFINITION  protein O-mannosyl-transferase TMEM260 isoform X4 [Homo sapiens].
ACCESSION   XP_047287451
VERSION     XP_047287451.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431495.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..441
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..441
                     /product="protein O-mannosyl-transferase TMEM260 isoform
                     X4"
                     /calculated_mol_wt=47928
     Region          52..206
                     /region_name="DUF2723"
                     /note="Protein of unknown function (DUF2723); pfam11028"
                     /db_xref="CDD:463208"
     CDS             1..441
                     /gene="TMEM260"
                     /gene_synonym="C14orf101; SHDRA"
                     /coded_by="XM_047431495.1:118..1443"
                     /db_xref="GeneID:54916"
                     /db_xref="HGNC:HGNC:20185"
                     /db_xref="MIM:617449"
ORIGIN      
        1 msphgdgrgq aqgravrvgl rrsggirggv avfaavaavf tftlppsvpg gdsgelitaa
       61 helgvahppg yplftlvakl aitlfpfgsi ayrvnllcgl fgavaasllf ftvfrlsgss
      121 aggilaagvf sfsrltwqws iaaevfslnn lfvgllmalt vhfeeaatak erskvakiga
      181 fccglslcnq htiilyvlci ipwilfqllk kkelslgsll klslyfsagl lpyvhlpiss
      241 ylnharwtwg dqttlqgflt hflreeygtf slakseigss mseillsqvt nmrtelsfni
      301 qalavcanic latkdrqnps lvwlftgmfc iyslffawra nldiskplfm gvverfwmqs
      361 navvavlagi glaavvsetn rvlnsnglqc lewlsatlfv vyqiysnyrg meyialllgg
      421 kmclitlqhr esvfvtkgpt m
//
LOCUS       XP_047287452             427 aa            linear   PRI 05-AUG-2025
DEFINITION  protein O-mannosyl-transferase TMEM260 isoform X5 [Homo sapiens].
ACCESSION   XP_047287452
VERSION     XP_047287452.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431496.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..427
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..427
                     /product="protein O-mannosyl-transferase TMEM260 isoform
                     X5"
                     /calculated_mol_wt=49408
     CDS             1..427
                     /gene="TMEM260"
                     /gene_synonym="C14orf101; SHDRA"
                     /coded_by="XM_047431496.1:415..1698"
                     /db_xref="GeneID:54916"
                     /db_xref="HGNC:HGNC:20185"
                     /db_xref="MIM:617449"
ORIGIN      
        1 mseillsqvt nmrtelsfni qalavcanic latkdrqnps lvwlftgmfc iyslffawra
       61 nldiskplfm gvverfwmqs navvavlagi glaavvsetn rvlnsnglqc lewlsatlfv
      121 vyqiysnysv cdqrtnyvid kfaknlltsm phdaiillrg dlpgnslrym hyceglrpdi
      181 slvdqemmty ewylpkmakh lpgvnfpgnr wnpvegilps gmvtfnlyhf levnkqketf
      241 vcigihegdp twkknyslwp wgscdklvpl eivfnpeewi kltksiynwt eeygrfdpss
      301 wesvaneemw qarmktpffi fnlaetahmp skvkaqlyaq aydlykeivy lqkehpvnwh
      361 knyaiacerm lrlqardadp evllsetirh frlysqkapn dpqqadilga lkhlrkelqs
      421 lrnrknv
//
LOCUS       XP_047287453             409 aa            linear   PRI 05-AUG-2025
DEFINITION  protein O-mannosyl-transferase TMEM260 isoform X6 [Homo sapiens].
ACCESSION   XP_047287453
VERSION     XP_047287453.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431497.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..409
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..409
                     /product="protein O-mannosyl-transferase TMEM260 isoform
                     X6"
                     /calculated_mol_wt=44408
     Region          52..206
                     /region_name="DUF2723"
                     /note="Protein of unknown function (DUF2723); pfam11028"
                     /db_xref="CDD:463208"
     CDS             1..409
                     /gene="TMEM260"
                     /gene_synonym="C14orf101; SHDRA"
                     /coded_by="XM_047431497.1:118..1347"
                     /db_xref="GeneID:54916"
                     /db_xref="HGNC:HGNC:20185"
                     /db_xref="MIM:617449"
ORIGIN      
        1 msphgdgrgq aqgravrvgl rrsggirggv avfaavaavf tftlppsvpg gdsgelitaa
       61 helgvahppg yplftlvakl aitlfpfgsi ayrvnllcgl fgavaasllf ftvfrlsgss
      121 aggilaagvf sfsrltwqws iaaevfslnn lfvgllmalt vhfeeaatak erskvakiga
      181 fccglslcnq htiilyvlci ipwilfqllk kkelslgsll klslyfsagl lpyvhlpiss
      241 ylnharwtwg dqttlqgflt hflreeygtf slakseigss mseillsqvt nmrtelsfni
      301 qalavcanic latkdrqnps lvwlftgmfc iyslffawra nldiskplfm gvverfwmqs
      361 navvavlagi glaavvsetn rvlnsnglqc lewlsatlfv vyqiysnyr
//
LOCUS       XP_047287454             360 aa            linear   PRI 05-AUG-2025
DEFINITION  protein O-mannosyl-transferase TMEM260 isoform X7 [Homo sapiens].
ACCESSION   XP_047287454
VERSION     XP_047287454.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431498.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..360
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..360
                     /product="protein O-mannosyl-transferase TMEM260 isoform
                     X7"
                     /calculated_mol_wt=41839
     CDS             1..360
                     /gene="TMEM260"
                     /gene_synonym="C14orf101; SHDRA"
                     /coded_by="XM_047431498.1:111..1193"
                     /db_xref="GeneID:54916"
                     /db_xref="HGNC:HGNC:20185"
                     /db_xref="MIM:617449"
ORIGIN      
        1 mfsnkverfw mqsnavvavl agiglaavvs etnrvlnsng lqclewlsat lfvvyqiysn
       61 ysvcdqrtny vidkfaknll tsmphdaiil lrgdlpgnsl rymhyceglr pdislvdqem
      121 mtyewylpkm akhlpgvnfp gnrwnpvegi lpsgmvtfnl yhflevnkqk etfvcigihe
      181 gdptwkknys lwpwgscdkl vpleivfnpe ewikltksiy nwteeygrfd psswesvane
      241 emwqarmktp ffifnlaeta hmpskvkaql yaqaydlyke ivylqkehpv nwhknyaiac
      301 ermlrlqard adpevllset irhfrlysqk apndpqqadi lgalkhlrke lqslrnrknv
//
LOCUS       XP_047287455             408 aa            linear   PRI 05-AUG-2025
DEFINITION  protein phosphatase 1A isoform X1 [Homo sapiens].
ACCESSION   XP_047287455
VERSION     XP_047287455.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431499.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..408
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..408
                     /product="protein phosphatase 1A isoform X1"
                     /calculated_mol_wt=45646
     Region          49..317
                     /region_name="PP2Cc"
                     /note="Serine/threonine phosphatases, family 2C, catalytic
                     domain; The protein architecture and deduced catalytic
                     mechanism of PP2C phosphatases are similar to the PP1,
                     PP2A, PP2B family of protein Ser/Thr phosphatases, with
                     which PP2C shares no sequence...; cd00143"
                     /db_xref="CDD:238083"
     Site            order(59,63..64,86..88,265,308)
                     /site_type="active"
                     /db_xref="CDD:238083"
     Region          311..389
                     /region_name="PP2C_C"
                     /note="Protein serine/threonine phosphatase 2C, C-terminal
                     domain; pfam07830"
                     /db_xref="CDD:429684"
     CDS             1..408
                     /gene="PPM1A"
                     /gene_synonym="PP2C-ALPHA; PP2CA; PP2Calpha"
                     /coded_by="XM_047431499.1:1592..2818"
                     /db_xref="GeneID:5494"
                     /db_xref="HGNC:HGNC:9275"
                     /db_xref="MIM:606108"
ORIGIN      
        1 mlihyiknqe tyeehqkwqd ledqdimgaf ldkpkmekhn aqgqgnglry glssmqgwrv
       61 emedahtavi glpsglesws ffavydghag sqvakycceh lldhitnnqd fkgsagapsv
      121 envkngirtg fleidehmrv msekkhgadr sgstavgvli spqhtyfinc gdsrgllcrn
      181 rkvhfftqdh kpsnpleker iqnaggsvmi qrvngslavs ralgdfdykc vhgkgpteql
      241 vspepevhdi erseeddqfi ilacdgiwdv mgneelcdfv rsrlevtddl ekvcnevvdt
      301 clykgsrdnm svilicfpna pkvspeavkk eaeldkylec rveeiikkqg egvpdlvhvm
      361 rtlasenips lppggelask rnvieavynr lnpyknddtd ststddmw
//
LOCUS       XP_047287456             408 aa            linear   PRI 05-AUG-2025
DEFINITION  protein phosphatase 1A isoform X1 [Homo sapiens].
ACCESSION   XP_047287456
VERSION     XP_047287456.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431500.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..408
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..408
                     /product="protein phosphatase 1A isoform X1"
                     /calculated_mol_wt=45646
     Region          49..317
                     /region_name="PP2Cc"
                     /note="Serine/threonine phosphatases, family 2C, catalytic
                     domain; The protein architecture and deduced catalytic
                     mechanism of PP2C phosphatases are similar to the PP1,
                     PP2A, PP2B family of protein Ser/Thr phosphatases, with
                     which PP2C shares no sequence...; cd00143"
                     /db_xref="CDD:238083"
     Site            order(59,63..64,86..88,265,308)
                     /site_type="active"
                     /db_xref="CDD:238083"
     Region          311..389
                     /region_name="PP2C_C"
                     /note="Protein serine/threonine phosphatase 2C, C-terminal
                     domain; pfam07830"
                     /db_xref="CDD:429684"
     CDS             1..408
                     /gene="PPM1A"
                     /gene_synonym="PP2C-ALPHA; PP2CA; PP2Calpha"
                     /coded_by="XM_047431500.1:1447..2673"
                     /db_xref="GeneID:5494"
                     /db_xref="HGNC:HGNC:9275"
                     /db_xref="MIM:606108"
ORIGIN      
        1 mlihyiknqe tyeehqkwqd ledqdimgaf ldkpkmekhn aqgqgnglry glssmqgwrv
       61 emedahtavi glpsglesws ffavydghag sqvakycceh lldhitnnqd fkgsagapsv
      121 envkngirtg fleidehmrv msekkhgadr sgstavgvli spqhtyfinc gdsrgllcrn
      181 rkvhfftqdh kpsnpleker iqnaggsvmi qrvngslavs ralgdfdykc vhgkgpteql
      241 vspepevhdi erseeddqfi ilacdgiwdv mgneelcdfv rsrlevtddl ekvcnevvdt
      301 clykgsrdnm svilicfpna pkvspeavkk eaeldkylec rveeiikkqg egvpdlvhvm
      361 rtlasenips lppggelask rnvieavynr lnpyknddtd ststddmw
//
LOCUS       XP_047287457             408 aa            linear   PRI 05-AUG-2025
DEFINITION  protein phosphatase 1A isoform X1 [Homo sapiens].
ACCESSION   XP_047287457
VERSION     XP_047287457.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431501.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..408
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..408
                     /product="protein phosphatase 1A isoform X1"
                     /calculated_mol_wt=45646
     Region          49..317
                     /region_name="PP2Cc"
                     /note="Serine/threonine phosphatases, family 2C, catalytic
                     domain; The protein architecture and deduced catalytic
                     mechanism of PP2C phosphatases are similar to the PP1,
                     PP2A, PP2B family of protein Ser/Thr phosphatases, with
                     which PP2C shares no sequence...; cd00143"
                     /db_xref="CDD:238083"
     Site            order(59,63..64,86..88,265,308)
                     /site_type="active"
                     /db_xref="CDD:238083"
     Region          311..389
                     /region_name="PP2C_C"
                     /note="Protein serine/threonine phosphatase 2C, C-terminal
                     domain; pfam07830"
                     /db_xref="CDD:429684"
     CDS             1..408
                     /gene="PPM1A"
                     /gene_synonym="PP2C-ALPHA; PP2CA; PP2Calpha"
                     /coded_by="XM_047431501.1:1490..2716"
                     /db_xref="GeneID:5494"
                     /db_xref="HGNC:HGNC:9275"
                     /db_xref="MIM:606108"
ORIGIN      
        1 mlihyiknqe tyeehqkwqd ledqdimgaf ldkpkmekhn aqgqgnglry glssmqgwrv
       61 emedahtavi glpsglesws ffavydghag sqvakycceh lldhitnnqd fkgsagapsv
      121 envkngirtg fleidehmrv msekkhgadr sgstavgvli spqhtyfinc gdsrgllcrn
      181 rkvhfftqdh kpsnpleker iqnaggsvmi qrvngslavs ralgdfdykc vhgkgpteql
      241 vspepevhdi erseeddqfi ilacdgiwdv mgneelcdfv rsrlevtddl ekvcnevvdt
      301 clykgsrdnm svilicfpna pkvspeavkk eaeldkylec rveeiikkqg egvpdlvhvm
      361 rtlasenips lppggelask rnvieavynr lnpyknddtd ststddmw
//
LOCUS       XP_016876872             408 aa            linear   PRI 05-AUG-2025
DEFINITION  protein phosphatase 1A isoform X1 [Homo sapiens].
ACCESSION   XP_016876872
VERSION     XP_016876872.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021383.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..408
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..408
                     /product="protein phosphatase 1A isoform X1"
                     /calculated_mol_wt=45646
     Region          49..317
                     /region_name="PP2Cc"
                     /note="Serine/threonine phosphatases, family 2C, catalytic
                     domain; The protein architecture and deduced catalytic
                     mechanism of PP2C phosphatases are similar to the PP1,
                     PP2A, PP2B family of protein Ser/Thr phosphatases, with
                     which PP2C shares no sequence...; cd00143"
                     /db_xref="CDD:238083"
     Site            order(59,63..64,86..88,265,308)
                     /site_type="active"
                     /db_xref="CDD:238083"
     Region          311..389
                     /region_name="PP2C_C"
                     /note="Protein serine/threonine phosphatase 2C, C-terminal
                     domain; pfam07830"
                     /db_xref="CDD:429684"
     CDS             1..408
                     /gene="PPM1A"
                     /gene_synonym="PP2C-ALPHA; PP2CA; PP2Calpha"
                     /coded_by="XM_017021383.2:520..1746"
                     /db_xref="GeneID:5494"
                     /db_xref="HGNC:HGNC:9275"
                     /db_xref="MIM:606108"
ORIGIN      
        1 mlihyiknqe tyeehqkwqd ledqdimgaf ldkpkmekhn aqgqgnglry glssmqgwrv
       61 emedahtavi glpsglesws ffavydghag sqvakycceh lldhitnnqd fkgsagapsv
      121 envkngirtg fleidehmrv msekkhgadr sgstavgvli spqhtyfinc gdsrgllcrn
      181 rkvhfftqdh kpsnpleker iqnaggsvmi qrvngslavs ralgdfdykc vhgkgpteql
      241 vspepevhdi erseeddqfi ilacdgiwdv mgneelcdfv rsrlevtddl ekvcnevvdt
      301 clykgsrdnm svilicfpna pkvspeavkk eaeldkylec rveeiikkqg egvpdlvhvm
      361 rtlasenips lppggelask rnvieavynr lnpyknddtd ststddmw
//
LOCUS       XP_047287458             406 aa            linear   PRI 05-AUG-2025
DEFINITION  protein phosphatase 1A isoform X2 [Homo sapiens].
ACCESSION   XP_047287458
VERSION     XP_047287458.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431502.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..406
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..406
                     /product="protein phosphatase 1A isoform X2"
                     /calculated_mol_wt=45166
     Region          47..315
                     /region_name="PP2Cc"
                     /note="Serine/threonine phosphatases, family 2C, catalytic
                     domain; The protein architecture and deduced catalytic
                     mechanism of PP2C phosphatases are similar to the PP1,
                     PP2A, PP2B family of protein Ser/Thr phosphatases, with
                     which PP2C shares no sequence...; cd00143"
                     /db_xref="CDD:238083"
     Site            order(57,61..62,84..86,263,306)
                     /site_type="active"
                     /db_xref="CDD:238083"
     Region          309..387
                     /region_name="PP2C_C"
                     /note="Protein serine/threonine phosphatase 2C, C-terminal
                     domain; pfam07830"
                     /db_xref="CDD:429684"
     CDS             1..406
                     /gene="PPM1A"
                     /gene_synonym="PP2C-ALPHA; PP2CA; PP2Calpha"
                     /coded_by="XM_047431502.1:204..1424"
                     /db_xref="GeneID:5494"
                     /db_xref="HGNC:HGNC:9275"
                     /db_xref="MIM:606108"
ORIGIN      
        1 mgeflqdsmf qtfccdhnle dqdimgafld kpkmekhnaq gqgnglrygl ssmqgwrvem
       61 edahtavigl psgleswsff avydghagsq vakyccehll dhitnnqdfk gsagapsven
      121 vkngirtgfl eidehmrvms ekkhgadrsg stavgvlisp qhtyfincgd srgllcrnrk
      181 vhfftqdhkp snplekeriq naggsvmiqr vngslavsra lgdfdykcvh gkgpteqlvs
      241 pepevhdier seeddqfiil acdgiwdvmg neelcdfvrs rlevtddlek vcnevvdtcl
      301 ykgsrdnmsv ilicfpnapk vspeavkkea eldkylecrv eeiikkqgeg vpdlvhvmrt
      361 lasenipslp pggelaskrn vieavynrln pyknddtdst stddmw
//
LOCUS       XP_047287459             382 aa            linear   PRI 05-AUG-2025
DEFINITION  protein phosphatase 1A isoform X3 [Homo sapiens].
ACCESSION   XP_047287459
VERSION     XP_047287459.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431503.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..382
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..382
                     /product="protein phosphatase 1A isoform X3"
                     /calculated_mol_wt=42317
     Region          23..291
                     /region_name="PP2Cc"
                     /note="Serine/threonine phosphatases, family 2C, catalytic
                     domain; The protein architecture and deduced catalytic
                     mechanism of PP2C phosphatases are similar to the PP1,
                     PP2A, PP2B family of protein Ser/Thr phosphatases, with
                     which PP2C shares no sequence...; cd00143"
                     /db_xref="CDD:238083"
     Site            order(33,37..38,60..62,239,282)
                     /site_type="active"
                     /db_xref="CDD:238083"
     Region          285..363
                     /region_name="PP2C_C"
                     /note="Protein serine/threonine phosphatase 2C, C-terminal
                     domain; pfam07830"
                     /db_xref="CDD:429684"
     CDS             1..382
                     /gene="PPM1A"
                     /gene_synonym="PP2C-ALPHA; PP2CA; PP2Calpha"
                     /coded_by="XM_047431503.1:7686..8834"
                     /db_xref="GeneID:5494"
                     /db_xref="HGNC:HGNC:9275"
                     /db_xref="MIM:606108"
ORIGIN      
        1 mgafldkpkm ekhnaqgqgn glryglssmq gwrvemedah taviglpsgl eswsffavyd
       61 ghagsqvaky ccehlldhit nnqdfkgsag apsvenvkng irtgfleide hmrvmsekkh
      121 gadrsgstav gvlispqhty fincgdsrgl lcrnrkvhff tqdhkpsnpl ekeriqnagg
      181 svmiqrvngs lavsralgdf dykcvhgkgp teqlvspepe vhdierseed dqfiilacdg
      241 iwdvmgneel cdfvrsrlev tddlekvcne vvdtclykgs rdnmsvilic fpnapkvspe
      301 avkkeaeldk ylecrveeii kkqgegvpdl vhvmrtlase nipslppgge laskrnviea
      361 vynrlnpykn ddtdststdd mw
//
LOCUS       XP_047287460             382 aa            linear   PRI 05-AUG-2025
DEFINITION  protein phosphatase 1A isoform X3 [Homo sapiens].
ACCESSION   XP_047287460
VERSION     XP_047287460.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431504.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..382
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..382
                     /product="protein phosphatase 1A isoform X3"
                     /calculated_mol_wt=42317
     Region          23..291
                     /region_name="PP2Cc"
                     /note="Serine/threonine phosphatases, family 2C, catalytic
                     domain; The protein architecture and deduced catalytic
                     mechanism of PP2C phosphatases are similar to the PP1,
                     PP2A, PP2B family of protein Ser/Thr phosphatases, with
                     which PP2C shares no sequence...; cd00143"
                     /db_xref="CDD:238083"
     Site            order(33,37..38,60..62,239,282)
                     /site_type="active"
                     /db_xref="CDD:238083"
     Region          285..363
                     /region_name="PP2C_C"
                     /note="Protein serine/threonine phosphatase 2C, C-terminal
                     domain; pfam07830"
                     /db_xref="CDD:429684"
     CDS             1..382
                     /gene="PPM1A"
                     /gene_synonym="PP2C-ALPHA; PP2CA; PP2Calpha"
                     /coded_by="XM_047431504.1:7329..8477"
                     /db_xref="GeneID:5494"
                     /db_xref="HGNC:HGNC:9275"
                     /db_xref="MIM:606108"
ORIGIN      
        1 mgafldkpkm ekhnaqgqgn glryglssmq gwrvemedah taviglpsgl eswsffavyd
       61 ghagsqvaky ccehlldhit nnqdfkgsag apsvenvkng irtgfleide hmrvmsekkh
      121 gadrsgstav gvlispqhty fincgdsrgl lcrnrkvhff tqdhkpsnpl ekeriqnagg
      181 svmiqrvngs lavsralgdf dykcvhgkgp teqlvspepe vhdierseed dqfiilacdg
      241 iwdvmgneel cdfvrsrlev tddlekvcne vvdtclykgs rdnmsvilic fpnapkvspe
      301 avkkeaeldk ylecrveeii kkqgegvpdl vhvmrtlase nipslppgge laskrnviea
      361 vynrlnpykn ddtdststdd mw
//
LOCUS       XP_011535183             382 aa            linear   PRI 05-AUG-2025
DEFINITION  protein phosphatase 1A isoform X3 [Homo sapiens].
ACCESSION   XP_011535183
VERSION     XP_011535183.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536881.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..382
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..382
                     /product="protein phosphatase 1A isoform X3"
                     /calculated_mol_wt=42317
     Region          23..291
                     /region_name="PP2Cc"
                     /note="Serine/threonine phosphatases, family 2C, catalytic
                     domain; The protein architecture and deduced catalytic
                     mechanism of PP2C phosphatases are similar to the PP1,
                     PP2A, PP2B family of protein Ser/Thr phosphatases, with
                     which PP2C shares no sequence...; cd00143"
                     /db_xref="CDD:238083"
     Site            order(33,37..38,60..62,239,282)
                     /site_type="active"
                     /db_xref="CDD:238083"
     Region          285..363
                     /region_name="PP2C_C"
                     /note="Protein serine/threonine phosphatase 2C, C-terminal
                     domain; pfam07830"
                     /db_xref="CDD:429684"
     CDS             1..382
                     /gene="PPM1A"
                     /gene_synonym="PP2C-ALPHA; PP2CA; PP2Calpha"
                     /coded_by="XM_011536881.4:883..2031"
                     /db_xref="GeneID:5494"
                     /db_xref="HGNC:HGNC:9275"
                     /db_xref="MIM:606108"
ORIGIN      
        1 mgafldkpkm ekhnaqgqgn glryglssmq gwrvemedah taviglpsgl eswsffavyd
       61 ghagsqvaky ccehlldhit nnqdfkgsag apsvenvkng irtgfleide hmrvmsekkh
      121 gadrsgstav gvlispqhty fincgdsrgl lcrnrkvhff tqdhkpsnpl ekeriqnagg
      181 svmiqrvngs lavsralgdf dykcvhgkgp teqlvspepe vhdierseed dqfiilacdg
      241 iwdvmgneel cdfvrsrlev tddlekvcne vvdtclykgs rdnmsvilic fpnapkvspe
      301 avkkeaeldk ylecrveeii kkqgegvpdl vhvmrtlase nipslppgge laskrnviea
      361 vynrlnpykn ddtdststdd mw
//
LOCUS       XP_047287461             382 aa            linear   PRI 05-AUG-2025
DEFINITION  protein phosphatase 1A isoform X3 [Homo sapiens].
ACCESSION   XP_047287461
VERSION     XP_047287461.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431505.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 20% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..382
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..382
                     /product="protein phosphatase 1A isoform X3"
                     /calculated_mol_wt=42317
     Region          23..291
                     /region_name="PP2Cc"
                     /note="Serine/threonine phosphatases, family 2C, catalytic
                     domain; The protein architecture and deduced catalytic
                     mechanism of PP2C phosphatases are similar to the PP1,
                     PP2A, PP2B family of protein Ser/Thr phosphatases, with
                     which PP2C shares no sequence...; cd00143"
                     /db_xref="CDD:238083"
     Site            order(33,37..38,60..62,239,282)
                     /site_type="active"
                     /db_xref="CDD:238083"
     Region          285..363
                     /region_name="PP2C_C"
                     /note="Protein serine/threonine phosphatase 2C, C-terminal
                     domain; pfam07830"
                     /db_xref="CDD:429684"
     CDS             1..382
                     /gene="PPM1A"
                     /gene_synonym="PP2C-ALPHA; PP2CA; PP2Calpha"
                     /coded_by="XM_047431505.1:1485..2633"
                     /db_xref="GeneID:5494"
                     /db_xref="HGNC:HGNC:9275"
                     /db_xref="MIM:606108"
ORIGIN      
        1 mgafldkpkm ekhnaqgqgn glryglssmq gwrvemedah taviglpsgl eswsffavyd
       61 ghagsqvaky ccehlldhit nnqdfkgsag apsvenvkng irtgfleide hmrvmsekkh
      121 gadrsgstav gvlispqhty fincgdsrgl lcrnrkvhff tqdhkpsnpl ekeriqnagg
      181 svmiqrvngs lavsralgdf dykcvhgkgp teqlvspepe vhdierseed dqfiilacdg
      241 iwdvmgneel cdfvrsrlev tddlekvcne vvdtclykgs rdnmsvilic fpnapkvspe
      301 avkkeaeldk ylecrveeii kkqgegvpdl vhvmrtlase nipslppgge laskrnviea
      361 vynrlnpykn ddtdststdd mw
//
LOCUS       XP_047287462             382 aa            linear   PRI 05-AUG-2025
DEFINITION  protein phosphatase 1A isoform X3 [Homo sapiens].
ACCESSION   XP_047287462
VERSION     XP_047287462.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431506.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..382
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..382
                     /product="protein phosphatase 1A isoform X3"
                     /calculated_mol_wt=42317
     Region          23..291
                     /region_name="PP2Cc"
                     /note="Serine/threonine phosphatases, family 2C, catalytic
                     domain; The protein architecture and deduced catalytic
                     mechanism of PP2C phosphatases are similar to the PP1,
                     PP2A, PP2B family of protein Ser/Thr phosphatases, with
                     which PP2C shares no sequence...; cd00143"
                     /db_xref="CDD:238083"
     Site            order(33,37..38,60..62,239,282)
                     /site_type="active"
                     /db_xref="CDD:238083"
     Region          285..363
                     /region_name="PP2C_C"
                     /note="Protein serine/threonine phosphatase 2C, C-terminal
                     domain; pfam07830"
                     /db_xref="CDD:429684"
     CDS             1..382
                     /gene="PPM1A"
                     /gene_synonym="PP2C-ALPHA; PP2CA; PP2Calpha"
                     /coded_by="XM_047431506.1:748..1896"
                     /db_xref="GeneID:5494"
                     /db_xref="HGNC:HGNC:9275"
                     /db_xref="MIM:606108"
ORIGIN      
        1 mgafldkpkm ekhnaqgqgn glryglssmq gwrvemedah taviglpsgl eswsffavyd
       61 ghagsqvaky ccehlldhit nnqdfkgsag apsvenvkng irtgfleide hmrvmsekkh
      121 gadrsgstav gvlispqhty fincgdsrgl lcrnrkvhff tqdhkpsnpl ekeriqnagg
      181 svmiqrvngs lavsralgdf dykcvhgkgp teqlvspepe vhdierseed dqfiilacdg
      241 iwdvmgneel cdfvrsrlev tddlekvcne vvdtclykgs rdnmsvilic fpnapkvspe
      301 avkkeaeldk ylecrveeii kkqgegvpdl vhvmrtlase nipslppgge laskrnviea
      361 vynrlnpykn ddtdststdd mw
//
LOCUS       XP_047287463             382 aa            linear   PRI 05-AUG-2025
DEFINITION  protein phosphatase 1A isoform X3 [Homo sapiens].
ACCESSION   XP_047287463
VERSION     XP_047287463.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431507.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..382
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..382
                     /product="protein phosphatase 1A isoform X3"
                     /calculated_mol_wt=42317
     Region          23..291
                     /region_name="PP2Cc"
                     /note="Serine/threonine phosphatases, family 2C, catalytic
                     domain; The protein architecture and deduced catalytic
                     mechanism of PP2C phosphatases are similar to the PP1,
                     PP2A, PP2B family of protein Ser/Thr phosphatases, with
                     which PP2C shares no sequence...; cd00143"
                     /db_xref="CDD:238083"
     Site            order(33,37..38,60..62,239,282)
                     /site_type="active"
                     /db_xref="CDD:238083"
     Region          285..363
                     /region_name="PP2C_C"
                     /note="Protein serine/threonine phosphatase 2C, C-terminal
                     domain; pfam07830"
                     /db_xref="CDD:429684"
     CDS             1..382
                     /gene="PPM1A"
                     /gene_synonym="PP2C-ALPHA; PP2CA; PP2Calpha"
                     /coded_by="XM_047431507.1:1011..2159"
                     /db_xref="GeneID:5494"
                     /db_xref="HGNC:HGNC:9275"
                     /db_xref="MIM:606108"
ORIGIN      
        1 mgafldkpkm ekhnaqgqgn glryglssmq gwrvemedah taviglpsgl eswsffavyd
       61 ghagsqvaky ccehlldhit nnqdfkgsag apsvenvkng irtgfleide hmrvmsekkh
      121 gadrsgstav gvlispqhty fincgdsrgl lcrnrkvhff tqdhkpsnpl ekeriqnagg
      181 svmiqrvngs lavsralgdf dykcvhgkgp teqlvspepe vhdierseed dqfiilacdg
      241 iwdvmgneel cdfvrsrlev tddlekvcne vvdtclykgs rdnmsvilic fpnapkvspe
      301 avkkeaeldk ylecrveeii kkqgegvpdl vhvmrtlase nipslppgge laskrnviea
      361 vynrlnpykn ddtdststdd mw
//
LOCUS       XP_047287464             382 aa            linear   PRI 05-AUG-2025
DEFINITION  protein phosphatase 1A isoform X3 [Homo sapiens].
ACCESSION   XP_047287464
VERSION     XP_047287464.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431508.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 21% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..382
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..382
                     /product="protein phosphatase 1A isoform X3"
                     /calculated_mol_wt=42317
     Region          23..291
                     /region_name="PP2Cc"
                     /note="Serine/threonine phosphatases, family 2C, catalytic
                     domain; The protein architecture and deduced catalytic
                     mechanism of PP2C phosphatases are similar to the PP1,
                     PP2A, PP2B family of protein Ser/Thr phosphatases, with
                     which PP2C shares no sequence...; cd00143"
                     /db_xref="CDD:238083"
     Site            order(33,37..38,60..62,239,282)
                     /site_type="active"
                     /db_xref="CDD:238083"
     Region          285..363
                     /region_name="PP2C_C"
                     /note="Protein serine/threonine phosphatase 2C, C-terminal
                     domain; pfam07830"
                     /db_xref="CDD:429684"
     CDS             1..382
                     /gene="PPM1A"
                     /gene_synonym="PP2C-ALPHA; PP2CA; PP2Calpha"
                     /coded_by="XM_047431508.1:808..1956"
                     /db_xref="GeneID:5494"
                     /db_xref="HGNC:HGNC:9275"
                     /db_xref="MIM:606108"
ORIGIN      
        1 mgafldkpkm ekhnaqgqgn glryglssmq gwrvemedah taviglpsgl eswsffavyd
       61 ghagsqvaky ccehlldhit nnqdfkgsag apsvenvkng irtgfleide hmrvmsekkh
      121 gadrsgstav gvlispqhty fincgdsrgl lcrnrkvhff tqdhkpsnpl ekeriqnagg
      181 svmiqrvngs lavsralgdf dykcvhgkgp teqlvspepe vhdierseed dqfiilacdg
      241 iwdvmgneel cdfvrsrlev tddlekvcne vvdtclykgs rdnmsvilic fpnapkvspe
      301 avkkeaeldk ylecrveeii kkqgegvpdl vhvmrtlase nipslppgge laskrnviea
      361 vynrlnpykn ddtdststdd mw
//
LOCUS       XP_047287465             382 aa            linear   PRI 05-AUG-2025
DEFINITION  protein phosphatase 1A isoform X3 [Homo sapiens].
ACCESSION   XP_047287465
VERSION     XP_047287465.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431509.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..382
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..382
                     /product="protein phosphatase 1A isoform X3"
                     /calculated_mol_wt=42317
     Region          23..291
                     /region_name="PP2Cc"
                     /note="Serine/threonine phosphatases, family 2C, catalytic
                     domain; The protein architecture and deduced catalytic
                     mechanism of PP2C phosphatases are similar to the PP1,
                     PP2A, PP2B family of protein Ser/Thr phosphatases, with
                     which PP2C shares no sequence...; cd00143"
                     /db_xref="CDD:238083"
     Site            order(33,37..38,60..62,239,282)
                     /site_type="active"
                     /db_xref="CDD:238083"
     Region          285..363
                     /region_name="PP2C_C"
                     /note="Protein serine/threonine phosphatase 2C, C-terminal
                     domain; pfam07830"
                     /db_xref="CDD:429684"
     CDS             1..382
                     /gene="PPM1A"
                     /gene_synonym="PP2C-ALPHA; PP2CA; PP2Calpha"
                     /coded_by="XM_047431509.1:341..1489"
                     /db_xref="GeneID:5494"
                     /db_xref="HGNC:HGNC:9275"
                     /db_xref="MIM:606108"
ORIGIN      
        1 mgafldkpkm ekhnaqgqgn glryglssmq gwrvemedah taviglpsgl eswsffavyd
       61 ghagsqvaky ccehlldhit nnqdfkgsag apsvenvkng irtgfleide hmrvmsekkh
      121 gadrsgstav gvlispqhty fincgdsrgl lcrnrkvhff tqdhkpsnpl ekeriqnagg
      181 svmiqrvngs lavsralgdf dykcvhgkgp teqlvspepe vhdierseed dqfiilacdg
      241 iwdvmgneel cdfvrsrlev tddlekvcne vvdtclykgs rdnmsvilic fpnapkvspe
      301 avkkeaeldk ylecrveeii kkqgegvpdl vhvmrtlase nipslppgge laskrnviea
      361 vynrlnpykn ddtdststdd mw
//
LOCUS       XP_047287466             382 aa            linear   PRI 05-AUG-2025
DEFINITION  protein phosphatase 1A isoform X3 [Homo sapiens].
ACCESSION   XP_047287466
VERSION     XP_047287466.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431510.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..382
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..382
                     /product="protein phosphatase 1A isoform X3"
                     /calculated_mol_wt=42317
     Region          23..291
                     /region_name="PP2Cc"
                     /note="Serine/threonine phosphatases, family 2C, catalytic
                     domain; The protein architecture and deduced catalytic
                     mechanism of PP2C phosphatases are similar to the PP1,
                     PP2A, PP2B family of protein Ser/Thr phosphatases, with
                     which PP2C shares no sequence...; cd00143"
                     /db_xref="CDD:238083"
     Site            order(33,37..38,60..62,239,282)
                     /site_type="active"
                     /db_xref="CDD:238083"
     Region          285..363
                     /region_name="PP2C_C"
                     /note="Protein serine/threonine phosphatase 2C, C-terminal
                     domain; pfam07830"
                     /db_xref="CDD:429684"
     CDS             1..382
                     /gene="PPM1A"
                     /gene_synonym="PP2C-ALPHA; PP2CA; PP2Calpha"
                     /coded_by="XM_047431510.1:891..2039"
                     /db_xref="GeneID:5494"
                     /db_xref="HGNC:HGNC:9275"
                     /db_xref="MIM:606108"
ORIGIN      
        1 mgafldkpkm ekhnaqgqgn glryglssmq gwrvemedah taviglpsgl eswsffavyd
       61 ghagsqvaky ccehlldhit nnqdfkgsag apsvenvkng irtgfleide hmrvmsekkh
      121 gadrsgstav gvlispqhty fincgdsrgl lcrnrkvhff tqdhkpsnpl ekeriqnagg
      181 svmiqrvngs lavsralgdf dykcvhgkgp teqlvspepe vhdierseed dqfiilacdg
      241 iwdvmgneel cdfvrsrlev tddlekvcne vvdtclykgs rdnmsvilic fpnapkvspe
      301 avkkeaeldk ylecrveeii kkqgegvpdl vhvmrtlase nipslppgge laskrnviea
      361 vynrlnpykn ddtdststdd mw
//
LOCUS       XP_047287467             382 aa            linear   PRI 05-AUG-2025
DEFINITION  protein phosphatase 1A isoform X3 [Homo sapiens].
ACCESSION   XP_047287467
VERSION     XP_047287467.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431511.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 20% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..382
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..382
                     /product="protein phosphatase 1A isoform X3"
                     /calculated_mol_wt=42317
     Region          23..291
                     /region_name="PP2Cc"
                     /note="Serine/threonine phosphatases, family 2C, catalytic
                     domain; The protein architecture and deduced catalytic
                     mechanism of PP2C phosphatases are similar to the PP1,
                     PP2A, PP2B family of protein Ser/Thr phosphatases, with
                     which PP2C shares no sequence...; cd00143"
                     /db_xref="CDD:238083"
     Site            order(33,37..38,60..62,239,282)
                     /site_type="active"
                     /db_xref="CDD:238083"
     Region          285..363
                     /region_name="PP2C_C"
                     /note="Protein serine/threonine phosphatase 2C, C-terminal
                     domain; pfam07830"
                     /db_xref="CDD:429684"
     CDS             1..382
                     /gene="PPM1A"
                     /gene_synonym="PP2C-ALPHA; PP2CA; PP2Calpha"
                     /coded_by="XM_047431511.1:731..1879"
                     /db_xref="GeneID:5494"
                     /db_xref="HGNC:HGNC:9275"
                     /db_xref="MIM:606108"
ORIGIN      
        1 mgafldkpkm ekhnaqgqgn glryglssmq gwrvemedah taviglpsgl eswsffavyd
       61 ghagsqvaky ccehlldhit nnqdfkgsag apsvenvkng irtgfleide hmrvmsekkh
      121 gadrsgstav gvlispqhty fincgdsrgl lcrnrkvhff tqdhkpsnpl ekeriqnagg
      181 svmiqrvngs lavsralgdf dykcvhgkgp teqlvspepe vhdierseed dqfiilacdg
      241 iwdvmgneel cdfvrsrlev tddlekvcne vvdtclykgs rdnmsvilic fpnapkvspe
      301 avkkeaeldk ylecrveeii kkqgegvpdl vhvmrtlase nipslppgge laskrnviea
      361 vynrlnpykn ddtdststdd mw
//
LOCUS       XP_047287468             382 aa            linear   PRI 05-AUG-2025
DEFINITION  protein phosphatase 1A isoform X3 [Homo sapiens].
ACCESSION   XP_047287468
VERSION     XP_047287468.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431512.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 20% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..382
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..382
                     /product="protein phosphatase 1A isoform X3"
                     /calculated_mol_wt=42317
     Region          23..291
                     /region_name="PP2Cc"
                     /note="Serine/threonine phosphatases, family 2C, catalytic
                     domain; The protein architecture and deduced catalytic
                     mechanism of PP2C phosphatases are similar to the PP1,
                     PP2A, PP2B family of protein Ser/Thr phosphatases, with
                     which PP2C shares no sequence...; cd00143"
                     /db_xref="CDD:238083"
     Site            order(33,37..38,60..62,239,282)
                     /site_type="active"
                     /db_xref="CDD:238083"
     Region          285..363
                     /region_name="PP2C_C"
                     /note="Protein serine/threonine phosphatase 2C, C-terminal
                     domain; pfam07830"
                     /db_xref="CDD:429684"
     CDS             1..382
                     /gene="PPM1A"
                     /gene_synonym="PP2C-ALPHA; PP2CA; PP2Calpha"
                     /coded_by="XM_047431512.1:588..1736"
                     /db_xref="GeneID:5494"
                     /db_xref="HGNC:HGNC:9275"
                     /db_xref="MIM:606108"
ORIGIN      
        1 mgafldkpkm ekhnaqgqgn glryglssmq gwrvemedah taviglpsgl eswsffavyd
       61 ghagsqvaky ccehlldhit nnqdfkgsag apsvenvkng irtgfleide hmrvmsekkh
      121 gadrsgstav gvlispqhty fincgdsrgl lcrnrkvhff tqdhkpsnpl ekeriqnagg
      181 svmiqrvngs lavsralgdf dykcvhgkgp teqlvspepe vhdierseed dqfiilacdg
      241 iwdvmgneel cdfvrsrlev tddlekvcne vvdtclykgs rdnmsvilic fpnapkvspe
      301 avkkeaeldk ylecrveeii kkqgegvpdl vhvmrtlase nipslppgge laskrnviea
      361 vynrlnpykn ddtdststdd mw
//
LOCUS       XP_047287469             382 aa            linear   PRI 05-AUG-2025
DEFINITION  protein phosphatase 1A isoform X3 [Homo sapiens].
ACCESSION   XP_047287469
VERSION     XP_047287469.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431513.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..382
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..382
                     /product="protein phosphatase 1A isoform X3"
                     /calculated_mol_wt=42317
     Region          23..291
                     /region_name="PP2Cc"
                     /note="Serine/threonine phosphatases, family 2C, catalytic
                     domain; The protein architecture and deduced catalytic
                     mechanism of PP2C phosphatases are similar to the PP1,
                     PP2A, PP2B family of protein Ser/Thr phosphatases, with
                     which PP2C shares no sequence...; cd00143"
                     /db_xref="CDD:238083"
     Site            order(33,37..38,60..62,239,282)
                     /site_type="active"
                     /db_xref="CDD:238083"
     Region          285..363
                     /region_name="PP2C_C"
                     /note="Protein serine/threonine phosphatase 2C, C-terminal
                     domain; pfam07830"
                     /db_xref="CDD:429684"
     CDS             1..382
                     /gene="PPM1A"
                     /gene_synonym="PP2C-ALPHA; PP2CA; PP2Calpha"
                     /coded_by="XM_047431513.1:791..1939"
                     /db_xref="GeneID:5494"
                     /db_xref="HGNC:HGNC:9275"
                     /db_xref="MIM:606108"
ORIGIN      
        1 mgafldkpkm ekhnaqgqgn glryglssmq gwrvemedah taviglpsgl eswsffavyd
       61 ghagsqvaky ccehlldhit nnqdfkgsag apsvenvkng irtgfleide hmrvmsekkh
      121 gadrsgstav gvlispqhty fincgdsrgl lcrnrkvhff tqdhkpsnpl ekeriqnagg
      181 svmiqrvngs lavsralgdf dykcvhgkgp teqlvspepe vhdierseed dqfiilacdg
      241 iwdvmgneel cdfvrsrlev tddlekvcne vvdtclykgs rdnmsvilic fpnapkvspe
      301 avkkeaeldk ylecrveeii kkqgegvpdl vhvmrtlase nipslppgge laskrnviea
      361 vynrlnpykn ddtdststdd mw
//
LOCUS       XP_047287470             382 aa            linear   PRI 05-AUG-2025
DEFINITION  protein phosphatase 1A isoform X3 [Homo sapiens].
ACCESSION   XP_047287470
VERSION     XP_047287470.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431514.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..382
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..382
                     /product="protein phosphatase 1A isoform X3"
                     /calculated_mol_wt=42317
     Region          23..291
                     /region_name="PP2Cc"
                     /note="Serine/threonine phosphatases, family 2C, catalytic
                     domain; The protein architecture and deduced catalytic
                     mechanism of PP2C phosphatases are similar to the PP1,
                     PP2A, PP2B family of protein Ser/Thr phosphatases, with
                     which PP2C shares no sequence...; cd00143"
                     /db_xref="CDD:238083"
     Site            order(33,37..38,60..62,239,282)
                     /site_type="active"
                     /db_xref="CDD:238083"
     Region          285..363
                     /region_name="PP2C_C"
                     /note="Protein serine/threonine phosphatase 2C, C-terminal
                     domain; pfam07830"
                     /db_xref="CDD:429684"
     CDS             1..382
                     /gene="PPM1A"
                     /gene_synonym="PP2C-ALPHA; PP2CA; PP2Calpha"
                     /coded_by="XM_047431514.1:661..1809"
                     /db_xref="GeneID:5494"
                     /db_xref="HGNC:HGNC:9275"
                     /db_xref="MIM:606108"
ORIGIN      
        1 mgafldkpkm ekhnaqgqgn glryglssmq gwrvemedah taviglpsgl eswsffavyd
       61 ghagsqvaky ccehlldhit nnqdfkgsag apsvenvkng irtgfleide hmrvmsekkh
      121 gadrsgstav gvlispqhty fincgdsrgl lcrnrkvhff tqdhkpsnpl ekeriqnagg
      181 svmiqrvngs lavsralgdf dykcvhgkgp teqlvspepe vhdierseed dqfiilacdg
      241 iwdvmgneel cdfvrsrlev tddlekvcne vvdtclykgs rdnmsvilic fpnapkvspe
      301 avkkeaeldk ylecrveeii kkqgegvpdl vhvmrtlase nipslppgge laskrnviea
      361 vynrlnpykn ddtdststdd mw
//
LOCUS       XP_047287471             382 aa            linear   PRI 05-AUG-2025
DEFINITION  protein phosphatase 1A isoform X3 [Homo sapiens].
ACCESSION   XP_047287471
VERSION     XP_047287471.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431515.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..382
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..382
                     /product="protein phosphatase 1A isoform X3"
                     /calculated_mol_wt=42317
     Region          23..291
                     /region_name="PP2Cc"
                     /note="Serine/threonine phosphatases, family 2C, catalytic
                     domain; The protein architecture and deduced catalytic
                     mechanism of PP2C phosphatases are similar to the PP1,
                     PP2A, PP2B family of protein Ser/Thr phosphatases, with
                     which PP2C shares no sequence...; cd00143"
                     /db_xref="CDD:238083"
     Site            order(33,37..38,60..62,239,282)
                     /site_type="active"
                     /db_xref="CDD:238083"
     Region          285..363
                     /region_name="PP2C_C"
                     /note="Protein serine/threonine phosphatase 2C, C-terminal
                     domain; pfam07830"
                     /db_xref="CDD:429684"
     CDS             1..382
                     /gene="PPM1A"
                     /gene_synonym="PP2C-ALPHA; PP2CA; PP2Calpha"
                     /coded_by="XM_047431515.1:704..1852"
                     /db_xref="GeneID:5494"
                     /db_xref="HGNC:HGNC:9275"
                     /db_xref="MIM:606108"
ORIGIN      
        1 mgafldkpkm ekhnaqgqgn glryglssmq gwrvemedah taviglpsgl eswsffavyd
       61 ghagsqvaky ccehlldhit nnqdfkgsag apsvenvkng irtgfleide hmrvmsekkh
      121 gadrsgstav gvlispqhty fincgdsrgl lcrnrkvhff tqdhkpsnpl ekeriqnagg
      181 svmiqrvngs lavsralgdf dykcvhgkgp teqlvspepe vhdierseed dqfiilacdg
      241 iwdvmgneel cdfvrsrlev tddlekvcne vvdtclykgs rdnmsvilic fpnapkvspe
      301 avkkeaeldk ylecrveeii kkqgegvpdl vhvmrtlase nipslppgge laskrnviea
      361 vynrlnpykn ddtdststdd mw
//
LOCUS       XP_011535185             382 aa            linear   PRI 05-AUG-2025
DEFINITION  protein phosphatase 1A isoform X3 [Homo sapiens].
ACCESSION   XP_011535185
VERSION     XP_011535185.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536883.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..382
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..382
                     /product="protein phosphatase 1A isoform X3"
                     /calculated_mol_wt=42317
     Region          23..291
                     /region_name="PP2Cc"
                     /note="Serine/threonine phosphatases, family 2C, catalytic
                     domain; The protein architecture and deduced catalytic
                     mechanism of PP2C phosphatases are similar to the PP1,
                     PP2A, PP2B family of protein Ser/Thr phosphatases, with
                     which PP2C shares no sequence...; cd00143"
                     /db_xref="CDD:238083"
     Site            order(33,37..38,60..62,239,282)
                     /site_type="active"
                     /db_xref="CDD:238083"
     Region          285..363
                     /region_name="PP2C_C"
                     /note="Protein serine/threonine phosphatase 2C, C-terminal
                     domain; pfam07830"
                     /db_xref="CDD:429684"
     CDS             1..382
                     /gene="PPM1A"
                     /gene_synonym="PP2C-ALPHA; PP2CA; PP2Calpha"
                     /coded_by="XM_011536883.2:531..1679"
                     /db_xref="GeneID:5494"
                     /db_xref="HGNC:HGNC:9275"
                     /db_xref="MIM:606108"
ORIGIN      
        1 mgafldkpkm ekhnaqgqgn glryglssmq gwrvemedah taviglpsgl eswsffavyd
       61 ghagsqvaky ccehlldhit nnqdfkgsag apsvenvkng irtgfleide hmrvmsekkh
      121 gadrsgstav gvlispqhty fincgdsrgl lcrnrkvhff tqdhkpsnpl ekeriqnagg
      181 svmiqrvngs lavsralgdf dykcvhgkgp teqlvspepe vhdierseed dqfiilacdg
      241 iwdvmgneel cdfvrsrlev tddlekvcne vvdtclykgs rdnmsvilic fpnapkvspe
      301 avkkeaeldk ylecrveeii kkqgegvpdl vhvmrtlase nipslppgge laskrnviea
      361 vynrlnpykn ddtdststdd mw
//
LOCUS       XP_047287472             382 aa            linear   PRI 05-AUG-2025
DEFINITION  protein phosphatase 1A isoform X3 [Homo sapiens].
ACCESSION   XP_047287472
VERSION     XP_047287472.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431516.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..382
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..382
                     /product="protein phosphatase 1A isoform X3"
                     /calculated_mol_wt=42317
     Region          23..291
                     /region_name="PP2Cc"
                     /note="Serine/threonine phosphatases, family 2C, catalytic
                     domain; The protein architecture and deduced catalytic
                     mechanism of PP2C phosphatases are similar to the PP1,
                     PP2A, PP2B family of protein Ser/Thr phosphatases, with
                     which PP2C shares no sequence...; cd00143"
                     /db_xref="CDD:238083"
     Site            order(33,37..38,60..62,239,282)
                     /site_type="active"
                     /db_xref="CDD:238083"
     Region          285..363
                     /region_name="PP2C_C"
                     /note="Protein serine/threonine phosphatase 2C, C-terminal
                     domain; pfam07830"
                     /db_xref="CDD:429684"
     CDS             1..382
                     /gene="PPM1A"
                     /gene_synonym="PP2C-ALPHA; PP2CA; PP2Calpha"
                     /coded_by="XM_047431516.1:85..1233"
                     /db_xref="GeneID:5494"
                     /db_xref="HGNC:HGNC:9275"
                     /db_xref="MIM:606108"
ORIGIN      
        1 mgafldkpkm ekhnaqgqgn glryglssmq gwrvemedah taviglpsgl eswsffavyd
       61 ghagsqvaky ccehlldhit nnqdfkgsag apsvenvkng irtgfleide hmrvmsekkh
      121 gadrsgstav gvlispqhty fincgdsrgl lcrnrkvhff tqdhkpsnpl ekeriqnagg
      181 svmiqrvngs lavsralgdf dykcvhgkgp teqlvspepe vhdierseed dqfiilacdg
      241 iwdvmgneel cdfvrsrlev tddlekvcne vvdtclykgs rdnmsvilic fpnapkvspe
      301 avkkeaeldk ylecrveeii kkqgegvpdl vhvmrtlase nipslppgge laskrnviea
      361 vynrlnpykn ddtdststdd mw
//
LOCUS       XP_024305405             382 aa            linear   PRI 05-AUG-2025
DEFINITION  protein phosphatase 1A isoform X3 [Homo sapiens].
ACCESSION   XP_024305405
VERSION     XP_024305405.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449637.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..382
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..382
                     /product="protein phosphatase 1A isoform X3"
                     /calculated_mol_wt=42317
     Region          23..291
                     /region_name="PP2Cc"
                     /note="Serine/threonine phosphatases, family 2C, catalytic
                     domain; The protein architecture and deduced catalytic
                     mechanism of PP2C phosphatases are similar to the PP1,
                     PP2A, PP2B family of protein Ser/Thr phosphatases, with
                     which PP2C shares no sequence...; cd00143"
                     /db_xref="CDD:238083"
     Site            order(33,37..38,60..62,239,282)
                     /site_type="active"
                     /db_xref="CDD:238083"
     Region          285..363
                     /region_name="PP2C_C"
                     /note="Protein serine/threonine phosphatase 2C, C-terminal
                     domain; pfam07830"
                     /db_xref="CDD:429684"
     CDS             1..382
                     /gene="PPM1A"
                     /gene_synonym="PP2C-ALPHA; PP2CA; PP2Calpha"
                     /coded_by="XM_024449637.2:521..1669"
                     /db_xref="GeneID:5494"
                     /db_xref="HGNC:HGNC:9275"
                     /db_xref="MIM:606108"
ORIGIN      
        1 mgafldkpkm ekhnaqgqgn glryglssmq gwrvemedah taviglpsgl eswsffavyd
       61 ghagsqvaky ccehlldhit nnqdfkgsag apsvenvkng irtgfleide hmrvmsekkh
      121 gadrsgstav gvlispqhty fincgdsrgl lcrnrkvhff tqdhkpsnpl ekeriqnagg
      181 svmiqrvngs lavsralgdf dykcvhgkgp teqlvspepe vhdierseed dqfiilacdg
      241 iwdvmgneel cdfvrsrlev tddlekvcne vvdtclykgs rdnmsvilic fpnapkvspe
      301 avkkeaeldk ylecrveeii kkqgegvpdl vhvmrtlase nipslppgge laskrnviea
      361 vynrlnpykn ddtdststdd mw
//
LOCUS       XP_005267839             453 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 2A regulatory subunit B''
            subunit gamma isoform X1 [Homo sapiens].
ACCESSION   XP_005267839
VERSION     XP_005267839.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267782.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..453
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..453
                     /product="serine/threonine-protein phosphatase 2A
                     regulatory subunit B'' subunit gamma isoform X1"
                     /calculated_mol_wt=53185
     Region          56..437
                     /region_name="PPP2R3C"
                     /note="serine/threonine protein phosphatase 2A regulatory
                     subunit B' subunit gamma; cd21505"
                     /db_xref="CDD:410338"
     CDS             1..453
                     /gene="PPP2R3C"
                     /gene_synonym="C14orf10; G4-1; G5pr; GDRM; MEGD; SPGF36"
                     /coded_by="XM_005267782.5:220..1581"
                     /db_xref="GeneID:55012"
                     /db_xref="HGNC:HGNC:17485"
                     /db_xref="MIM:615902"
ORIGIN      
        1 mdwkevlrrr latpntcpnk kkseqelkde emdlftkyys ewkggrkntn efyktiprfy
       61 yrlpaedevl lqklreesra vflqrksrel ldneelqnlw flldkhqtpp migeeaminy
      121 enflkvgeka gakckqffta kvfakllhtd sygrisimqf fnyvmrkvwl hqtriglsly
      181 dvagqgylre sdlenyilel iptlpqldgl eksfysfyvc tavrkffffl dplrtgkiki
      241 qdilacsfld dllelrdeel skesqetnwf sapsalrvyg qylnldkdhn gmlskeelsr
      301 ygtatmtnvf ldrvfqeclt ydgemdykty ldfvlalenr kepaalqyif klldienkgy
      361 lnvfslnyff raiqelmkih gqdpvsfqdv kdeifdmvkp kdplkislqd linsnqgdtv
      421 ttilidlngf wtyenrealv andsensadl ddt
//
LOCUS       XP_024305406             422 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 2A regulatory subunit B''
            subunit gamma isoform X2 [Homo sapiens].
ACCESSION   XP_024305406
VERSION     XP_024305406.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449638.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..422
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..422
                     /product="serine/threonine-protein phosphatase 2A
                     regulatory subunit B'' subunit gamma isoform X2"
                     /calculated_mol_wt=49430
     Region          25..406
                     /region_name="PPP2R3C"
                     /note="serine/threonine protein phosphatase 2A regulatory
                     subunit B' subunit gamma; cd21505"
                     /db_xref="CDD:410338"
     CDS             1..422
                     /gene="PPP2R3C"
                     /gene_synonym="C14orf10; G4-1; G5pr; GDRM; MEGD; SPGF36"
                     /coded_by="XM_024449638.2:315..1583"
                     /db_xref="GeneID:55012"
                     /db_xref="HGNC:HGNC:17485"
                     /db_xref="MIM:615902"
ORIGIN      
        1 mdlftkyyse wkggrkntne fyktiprfyy rlpaedevll qklreesrav flqrksrell
       61 dneelqnlwf lldkhqtppm igeeaminye nflkvgekag akckqfftak vfakllhtds
      121 ygrisimqff nyvmrkvwlh qtriglslyd vagqgylres dlenyileli ptlpqldgle
      181 ksfysfyvct avrkffffld plrtgkikiq dilacsfldd llelrdeels kesqetnwfs
      241 apsalrvygq ylnldkdhng mlskeelsry gtatmtnvfl drvfqeclty dgemdyktyl
      301 dfvlalenrk epaalqyifk lldienkgyl nvfslnyffr aiqelmkihg qdpvsfqdvk
      361 deifdmvkpk dplkislqdl insnqgdtvt tilidlngfw tyenrealva ndsensadld
      421 dt
//
LOCUS       XP_024305407             401 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 2A regulatory subunit B''
            subunit gamma isoform X3 [Homo sapiens].
ACCESSION   XP_024305407
VERSION     XP_024305407.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449639.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..401
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..401
                     /product="serine/threonine-protein phosphatase 2A
                     regulatory subunit B'' subunit gamma isoform X3"
                     /calculated_mol_wt=46577
     Region          9..385
                     /region_name="PPP2R3C"
                     /note="serine/threonine protein phosphatase 2A regulatory
                     subunit B' subunit gamma; cd21505"
                     /db_xref="CDD:410338"
     CDS             1..401
                     /gene="PPP2R3C"
                     /gene_synonym="C14orf10; G4-1; G5pr; GDRM; MEGD; SPGF36"
                     /coded_by="XM_024449639.2:794..1999"
                     /db_xref="GeneID:55012"
                     /db_xref="HGNC:HGNC:17485"
                     /db_xref="MIM:615902"
ORIGIN      
        1 mvfagqeelq lpaedevllq klreesravf lqrksrelld neelqnlwfl ldkhqtppmi
       61 geeaminyen flkvgekaga kckqfftakv fakllhtdsy grisimqffn yvmrkvwlhq
      121 triglslydv agqgylresd lenyilelip tlpqldglek sfysfyvcta vrkffffldp
      181 lrtgkikiqd ilacsflddl lelrdeelsk esqetnwfsa psalrvygqy lnldkdhngm
      241 lskeelsryg tatmtnvfld rvfqecltyd gemdyktyld fvlalenrke paalqyifkl
      301 ldienkgyln vfslnyffra iqelmkihgq dpvsfqdvkd eifdmvkpkd plkislqdli
      361 nsnqgdtvtt ilidlngfwt yenrealvan dsensadldd t
//
LOCUS       XP_047287473             281 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 2A regulatory subunit B''
            subunit gamma isoform X4 [Homo sapiens].
ACCESSION   XP_047287473
VERSION     XP_047287473.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431517.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..281
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..281
                     /product="serine/threonine-protein phosphatase 2A
                     regulatory subunit B'' subunit gamma isoform X4"
                     /calculated_mol_wt=33238
     Region          56..>280
                     /region_name="PPP2R3C"
                     /note="serine/threonine protein phosphatase 2A regulatory
                     subunit B' subunit gamma; cd21505"
                     /db_xref="CDD:410338"
     CDS             1..281
                     /gene="PPP2R3C"
                     /gene_synonym="C14orf10; G4-1; G5pr; GDRM; MEGD; SPGF36"
                     /coded_by="XM_047431517.1:220..1065"
                     /db_xref="GeneID:55012"
                     /db_xref="HGNC:HGNC:17485"
                     /db_xref="MIM:615902"
ORIGIN      
        1 mdwkevlrrr latpntcpnk kkseqelkde emdlftkyys ewkggrkntn efyktiprfy
       61 yrlpaedevl lqklreesra vflqrksrel ldneelqnlw flldkhqtpp migeeaminy
      121 enflkvgeka gakckqffta kvfakllhtd sygrisimqf fnyvmrkvwl hqtriglsly
      181 dvagqgylre sdlenyilel iptlpqldgl eksfysfyvc tavrkffffl dplrtgkiki
      241 qdilacsfld dllelrdeel skesqetnwf sapsalrvyg l
//
LOCUS       XP_016876879             140 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein C14orf119 isoform X1 [Homo sapiens].
ACCESSION   XP_016876879
VERSION     XP_016876879.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021390.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..140
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..140
                     /product="uncharacterized protein C14orf119 isoform X1"
                     /calculated_mol_wt=15878
     Region          36..133
                     /region_name="DUF4508"
                     /note="Domain of unknown function (DUF4508); pfam14969"
                     /db_xref="CDD:464413"
     CDS             1..140
                     /gene="C14orf119"
                     /coded_by="XM_017021390.3:320..742"
                     /db_xref="GeneID:55017"
                     /db_xref="HGNC:HGNC:20270"
ORIGIN      
        1 mplessssmp lsfpsllpsv phntnpsppl msyitsqemk cilhwfanws gpqrerfled
       61 lvakavpekl qplldsleql svsgadrpps ifecqlhlwd qwfrgwaeqe rnefvrqlef
      121 sepdfvakfy qavaatagkd
//
LOCUS       XP_016876880             715 aa            linear   PRI 05-AUG-2025
DEFINITION  F-box only protein 34 isoform X1 [Homo sapiens].
ACCESSION   XP_016876880
VERSION     XP_016876880.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021391.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..715
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..715
                     /product="F-box only protein 34 isoform X1"
                     /calculated_mol_wt=79015
     Region          579..626
                     /region_name="F-box_FBXO34"
                     /note="F-box domain found in F-box only protein 34
                     (FBXO34) and similar proteins; cd22176"
                     /db_xref="CDD:438947"
     Site            order(582,586,589..590,593..594,598,600..601,605..607,609)
                     /site_type="other"
                     /note="putative Skp1 binding site [polypeptide binding]"
                     /db_xref="CDD:438947"
     CDS             1..715
                     /gene="FBXO34"
                     /gene_synonym="CGI-301; Fbx34"
                     /coded_by="XM_017021391.2:205..2352"
                     /db_xref="GeneID:55030"
                     /db_xref="HGNC:HGNC:20201"
                     /db_xref="MIM:609104"
ORIGIN      
        1 mgfvmhlkpy wklqkkehpp evsretqrtp mnhqkavnde tckashitss vfpsaslgka
       61 ssrkpfgils pnvlcsmsgk spvesslnvk tkknapsati hqgeeegpld iwavvkpgnt
      121 kekiaffash qcsnrigsmk iksswdidgr atkrrkksgd lkkakvqver mrevnsrcyq
      181 pepfacgieh csvhyvsdsg dgvyagrpls viqmvafleq rasallascs knctnspaiv
      241 rfsgqsrgvp avsesysapg aceeptergn levgepqsep vrvldmvakl eseclkrqgq
      301 repgslsrnn sfrrnvgrvl lanstqadeg ktkkgvleap dtqvnpvgsv svdcgpsrad
      361 rcspkedqaw dgasqdcppl pagvsfhids aelepgsqta vknsnrydve mtdelvglpf
      421 sshtysqase lptdavdcms relvsltsrn pdqrkeslci sitvskvdkd qpsilnsced
      481 pvpgmlfflp pgqhlsdysq lnesttkess easqledaag gdsaseeksg saepfvlpas
      541 svestlpvle asswkkqvsh dfletrfkiq qllepqqyma flphhimvki frllptkslv
      601 alkctccyfk fiieyynirp adsrwvrdpr yredpckqck kkyvkgdvsl crwhpkpycq
      661 alpygpgywm cchrsqkgfp gcklglhdnh wvpachsfnr aihkkakgte aeeey
//
LOCUS       XP_016876882             711 aa            linear   PRI 05-AUG-2025
DEFINITION  F-box only protein 34 isoform X2 [Homo sapiens].
ACCESSION   XP_016876882
VERSION     XP_016876882.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021393.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..711
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..711
                     /product="F-box only protein 34 isoform X2"
                     /calculated_mol_wt=78580
     Region          575..622
                     /region_name="F-box_FBXO34"
                     /note="F-box domain found in F-box only protein 34
                     (FBXO34) and similar proteins; cd22176"
                     /db_xref="CDD:438947"
     Site            order(578,582,585..586,589..590,594,596..597,601..603,605)
                     /site_type="other"
                     /note="putative Skp1 binding site [polypeptide binding]"
                     /db_xref="CDD:438947"
     CDS             1..711
                     /gene="FBXO34"
                     /gene_synonym="CGI-301; Fbx34"
                     /coded_by="XM_017021393.3:3182..5317"
                     /db_xref="GeneID:55030"
                     /db_xref="HGNC:HGNC:20201"
                     /db_xref="MIM:609104"
ORIGIN      
        1 mhlkpywklq kkehppevsr etqrtpmnhq kavndetcka shitssvfps aslgkassrk
       61 pfgilspnvl csmsgkspve sslnvktkkn apsatihqge eegpldiwav vkpgntkeki
      121 affashqcsn rigsmkikss wdidgratkr rkksgdlkka kvqvermrev nsrcyqpepf
      181 acgiehcsvh yvsdsgdgvy agrplsviqm vafleqrasa llascsknct nspaivrfsg
      241 qsrgvpavse sysapgacee ptergnlevg epqsepvrvl dmvaklesec lkrqgqrepg
      301 slsrnnsfrr nvgrvllans tqadegktkk gvleapdtqv npvgsvsvdc gpsradrcsp
      361 kedqawdgas qdcpplpagv sfhidsaele pgsqtavkns nrydvemtde lvglpfssht
      421 ysqaselptd avdcmsrelv sltsrnpdqr keslcisitv skvdkdqpsi lnscedpvpg
      481 mlfflppgqh lsdysqlnes ttkesseasq ledaaggdsa seeksgsaep fvlpassves
      541 tlpvleassw kkqvshdfle trfkiqqlle pqqymaflph himvkifrll ptkslvalkc
      601 tccyfkfiie yynirpadsr wvrdpryred pckqckkkyv kgdvslcrwh pkpycqalpy
      661 gpgywmcchr sqkgfpgckl glhdnhwvpa chsfnraihk kakgteaeee y
//
LOCUS       XP_006720248             711 aa            linear   PRI 05-AUG-2025
DEFINITION  F-box only protein 34 isoform X2 [Homo sapiens].
ACCESSION   XP_006720248
VERSION     XP_006720248.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720185.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..711
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..711
                     /product="F-box only protein 34 isoform X2"
                     /calculated_mol_wt=78580
     Region          575..622
                     /region_name="F-box_FBXO34"
                     /note="F-box domain found in F-box only protein 34
                     (FBXO34) and similar proteins; cd22176"
                     /db_xref="CDD:438947"
     Site            order(578,582,585..586,589..590,594,596..597,601..603,605)
                     /site_type="other"
                     /note="putative Skp1 binding site [polypeptide binding]"
                     /db_xref="CDD:438947"
     CDS             1..711
                     /gene="FBXO34"
                     /gene_synonym="CGI-301; Fbx34"
                     /coded_by="XM_006720185.4:87..2222"
                     /db_xref="GeneID:55030"
                     /db_xref="HGNC:HGNC:20201"
                     /db_xref="MIM:609104"
ORIGIN      
        1 mhlkpywklq kkehppevsr etqrtpmnhq kavndetcka shitssvfps aslgkassrk
       61 pfgilspnvl csmsgkspve sslnvktkkn apsatihqge eegpldiwav vkpgntkeki
      121 affashqcsn rigsmkikss wdidgratkr rkksgdlkka kvqvermrev nsrcyqpepf
      181 acgiehcsvh yvsdsgdgvy agrplsviqm vafleqrasa llascsknct nspaivrfsg
      241 qsrgvpavse sysapgacee ptergnlevg epqsepvrvl dmvaklesec lkrqgqrepg
      301 slsrnnsfrr nvgrvllans tqadegktkk gvleapdtqv npvgsvsvdc gpsradrcsp
      361 kedqawdgas qdcpplpagv sfhidsaele pgsqtavkns nrydvemtde lvglpfssht
      421 ysqaselptd avdcmsrelv sltsrnpdqr keslcisitv skvdkdqpsi lnscedpvpg
      481 mlfflppgqh lsdysqlnes ttkesseasq ledaaggdsa seeksgsaep fvlpassves
      541 tlpvleassw kkqvshdfle trfkiqqlle pqqymaflph himvkifrll ptkslvalkc
      601 tccyfkfiie yynirpadsr wvrdpryred pckqckkkyv kgdvslcrwh pkpycqalpy
      661 gpgywmcchr sqkgfpgckl glhdnhwvpa chsfnraihk kakgteaeee y
//
LOCUS       XP_011535194             467 aa            linear   PRI 05-AUG-2025
DEFINITION  putative RNA-binding protein 23 isoform X1 [Homo sapiens].
ACCESSION   XP_011535194
VERSION     XP_011535194.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536892.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..467
                     /product="putative RNA-binding protein 23 isoform X1"
                     /calculated_mol_wt=51511
     Region          113..466
                     /region_name="SF-CC1"
                     /note="splicing factor, CC1-like family; TIGR01622"
                     /db_xref="CDD:273721"
     CDS             1..467
                     /gene="RBM23"
                     /gene_synonym="CAPERbeta; PP239; RNPC4"
                     /coded_by="XM_011536892.3:152..1555"
                     /db_xref="GeneID:55147"
                     /db_xref="HGNC:HGNC:20155"
                     /db_xref="MIM:621023"
ORIGIN      
        1 mescsvtqag aqwrvlgslq ppppgfkqfl chslpsswdy rsdrmasddf divieamlea
       61 pykkeedeqq rkevkkdyps nttsstsnsg netsgsstig etsnrsrdrd ryrrrnsrsr
      121 spgrqcrhrs rswdrrhgse srsrdhrred rvhyrsppla tgyryghsks phfrekspvr
      181 epvdnlspee rdartvfcmq laarirprdl edffsavgkv rdvriisdrn srrskgiayv
      241 efceiqsvpl aigltgqrll gvpiivqasq aeknrlaama nnlqkgnggp mrlyvgslhf
      301 nitedmlrgi fepfgkidni vlmkdsdtgr skgygfitfs dsecarrale qlngfelagr
      361 pmrvghvter ldggtditfp dgdqeldlgs aggrfqlmak laegagiqlp staaaaaaaa
      421 aqaaalqlng avplgalnpa altalspaln lasqcfqlss lftpqtm
//
LOCUS       XP_011535195             467 aa            linear   PRI 05-AUG-2025
DEFINITION  putative RNA-binding protein 23 isoform X2 [Homo sapiens].
ACCESSION   XP_011535195
VERSION     XP_011535195.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536893.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..467
                     /product="putative RNA-binding protein 23 isoform X2"
                     /calculated_mol_wt=51511
     Region          113..466
                     /region_name="SF-CC1"
                     /note="splicing factor, CC1-like family; TIGR01622"
                     /db_xref="CDD:273721"
     CDS             1..467
                     /gene="RBM23"
                     /gene_synonym="CAPERbeta; PP239; RNPC4"
                     /coded_by="XM_011536893.4:152..1555"
                     /db_xref="GeneID:55147"
                     /db_xref="HGNC:HGNC:20155"
                     /db_xref="MIM:621023"
ORIGIN      
        1 mescsvtqag aqwrvlgslq ppppgfkqfl chslpsswdy rsdrmasddf divieamlea
       61 pykkeedeqq rkevkkdyps nttsstsnsg netsgsstig etsnrsrdrd ryrrrnsrsr
      121 spgrqcrhrs rswdrrhgse srsrdhrred rvhyrsppla tgyryghsks phfrekspvr
      181 epvdnlspee rdartvfcmq laarirprdl edffsavgkv rdvriisdrn srrskgiayv
      241 efceiqsvpl aigltgqrll gvpiivqasq aeknrlaama nnlqkgnggp mrlyvgslhf
      301 nitedmlrgi fepfgkidni vlmkdsdtgr skgygfitfs dsecarrale qlngfelagr
      361 pmrvghvter ldggtditfp dgdqeldlgs aggrfqlmak laegagiqlp staaaaaaaa
      421 aqaaalqlng avplgalnpa altalspaln lasqcfqlss lftpqtm
//
LOCUS       XP_011535196             465 aa            linear   PRI 05-AUG-2025
DEFINITION  putative RNA-binding protein 23 isoform X3 [Homo sapiens].
ACCESSION   XP_011535196
VERSION     XP_011535196.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536894.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..465
                     /product="putative RNA-binding protein 23 isoform X3"
                     /calculated_mol_wt=51320
     Region          139..464
                     /region_name="SF-CC1"
                     /note="splicing factor, CC1-like family; TIGR01622"
                     /db_xref="CDD:273721"
     CDS             1..465
                     /gene="RBM23"
                     /gene_synonym="CAPERbeta; PP239; RNPC4"
                     /coded_by="XM_011536894.3:152..1549"
                     /db_xref="GeneID:55147"
                     /db_xref="HGNC:HGNC:20155"
                     /db_xref="MIM:621023"
ORIGIN      
        1 mescsvtqag aqwrvlgslq ppppgfkqfl chslpsswdy rsdrmasddf divieamlea
       61 pykkeedeqq rkevkkdyps nttsstsnsg netsgsstig etskkkrsrs hnksrdrkrs
      121 rsrdrdryrr rnsrsrspgr qcrhrsrswd rrhgsesrsr dhrredrvhy rspplatgep
      181 vdnlspeerd artvfcmqla arirprdled ffsavgkvrd vriisdrnsr rskgiayvef
      241 ceiqsvplai gltgqrllgv piivqasqae knrlaamann lqkgnggpmr lyvgslhfni
      301 tedmlrgife pfgkidnivl mkdsdtgrsk gygfitfsds ecarraleql ngfelagrpm
      361 rvghvterld ggtditfpdg dqeldlgsag grfqlmakla egagiqlpst aaaaaaaaaq
      421 aaalqlngav plgalnpaal talspalnla sqcfqlsslf tpqtm
//
LOCUS       XP_011535197             449 aa            linear   PRI 05-AUG-2025
DEFINITION  putative RNA-binding protein 23 isoform X4 [Homo sapiens].
ACCESSION   XP_011535197
VERSION     XP_011535197.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536895.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..449
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..449
                     /product="putative RNA-binding protein 23 isoform X4"
                     /calculated_mol_wt=49298
     Region          123..448
                     /region_name="SF-CC1"
                     /note="splicing factor, CC1-like family; TIGR01622"
                     /db_xref="CDD:273721"
     CDS             1..449
                     /gene="RBM23"
                     /gene_synonym="CAPERbeta; PP239; RNPC4"
                     /coded_by="XM_011536895.4:152..1501"
                     /db_xref="GeneID:55147"
                     /db_xref="HGNC:HGNC:20155"
                     /db_xref="MIM:621023"
ORIGIN      
        1 mescsvtqag aqwrvlgslq ppppgfkqfl chslpsswdy rsdrmasddf divieamlea
       61 pykkeedeqq rkevkkdyps nttsstsnsg netsgsstig etsnrsrdrd ryrrrnsrsr
      121 spgrqcrhrs rswdrrhgse srsrdhrred rvhyrsppla tgepvdnlsp eerdartvfc
      181 mqlaarirpr dledffsavg kvrdvriisd rnsrrskgia yvefceiqsv plaigltgqr
      241 llgvpiivqa sqaeknrlaa mannlqkgng gpmrlyvgsl hfnitedmlr gifepfgkid
      301 nivlmkdsdt grskgygfit fsdsecarra leqlngfela grpmrvghvt erldggtdit
      361 fpdgdqeldl gsaggrfqlm aklaegagiq lpstaaaaaa aaaqaaalql ngavplgaln
      421 paaltalspa lnlasqcfql sslftpqtm
//
LOCUS       XP_011535198             449 aa            linear   PRI 05-AUG-2025
DEFINITION  putative RNA-binding protein 23 isoform X5 [Homo sapiens].
ACCESSION   XP_011535198
VERSION     XP_011535198.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536896.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..449
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..449
                     /product="putative RNA-binding protein 23 isoform X5"
                     /calculated_mol_wt=49298
     Region          123..448
                     /region_name="SF-CC1"
                     /note="splicing factor, CC1-like family; TIGR01622"
                     /db_xref="CDD:273721"
     CDS             1..449
                     /gene="RBM23"
                     /gene_synonym="CAPERbeta; PP239; RNPC4"
                     /coded_by="XM_011536896.3:152..1501"
                     /db_xref="GeneID:55147"
                     /db_xref="HGNC:HGNC:20155"
                     /db_xref="MIM:621023"
ORIGIN      
        1 mescsvtqag aqwrvlgslq ppppgfkqfl chslpsswdy rsdrmasddf divieamlea
       61 pykkeedeqq rkevkkdyps nttsstsnsg netsgsstig etsnrsrdrd ryrrrnsrsr
      121 spgrqcrhrs rswdrrhgse srsrdhrred rvhyrsppla tgepvdnlsp eerdartvfc
      181 mqlaarirpr dledffsavg kvrdvriisd rnsrrskgia yvefceiqsv plaigltgqr
      241 llgvpiivqa sqaeknrlaa mannlqkgng gpmrlyvgsl hfnitedmlr gifepfgkid
      301 nivlmkdsdt grskgygfit fsdsecarra leqlngfela grpmrvghvt erldggtdit
      361 fpdgdqeldl gsaggrfqlm aklaegagiq lpstaaaaaa aaaqaaalql ngavplgaln
      421 paaltalspa lnlasqcfql sslftpqtm
//
LOCUS       XP_011535199             441 aa            linear   PRI 05-AUG-2025
DEFINITION  putative RNA-binding protein 23 isoform X6 [Homo sapiens].
ACCESSION   XP_011535199
VERSION     XP_011535199.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536897.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..441
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..441
                     /product="putative RNA-binding protein 23 isoform X6"
                     /calculated_mol_wt=48663
     Region          87..440
                     /region_name="SF-CC1"
                     /note="splicing factor, CC1-like family; TIGR01622"
                     /db_xref="CDD:273721"
     CDS             1..441
                     /gene="RBM23"
                     /gene_synonym="CAPERbeta; PP239; RNPC4"
                     /coded_by="XM_011536897.3:379..1704"
                     /db_xref="GeneID:55147"
                     /db_xref="HGNC:HGNC:20155"
                     /db_xref="MIM:621023"
ORIGIN      
        1 mwrnpvsakn ttlarsdrma sddfdiviea mleapykkee deqqrkevkk dypsnttsst
       61 snsgnetsgs stigetsnrs rdrdryrrrn srsrspgrqc rhrsrswdrr hgsesrsrdh
      121 rredrvhyrs pplatgyryg hsksphfrek spvrepvdnl speerdartv fcmqlaarir
      181 prdledffsa vgkvrdvrii sdrnsrrskg iayvefceiq svplaigltg qrllgvpiiv
      241 qasqaeknrl aamannlqkg nggpmrlyvg slhfnitedm lrgifepfgk idnivlmkds
      301 dtgrskgygf itfsdsecar raleqlngfe lagrpmrvgh vterldggtd itfpdgdqel
      361 dlgsaggrfq lmaklaegag iqlpstaaaa aaaaaqaaal qlngavplga lnpaaltals
      421 palnlasqcf qlsslftpqt m
//
LOCUS       XP_024305412             363 aa            linear   PRI 05-AUG-2025
DEFINITION  putative RNA-binding protein 23 isoform X7 [Homo sapiens].
ACCESSION   XP_024305412
VERSION     XP_024305412.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449644.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..363
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..363
                     /product="putative RNA-binding protein 23 isoform X7"
                     /calculated_mol_wt=41338
     Region          143..>356
                     /region_name="SF-CC1"
                     /note="splicing factor, CC1-like family; TIGR01622"
                     /db_xref="CDD:273721"
     CDS             1..363
                     /gene="RBM23"
                     /gene_synonym="CAPERbeta; PP239; RNPC4"
                     /coded_by="XM_024449644.2:152..1243"
                     /db_xref="GeneID:55147"
                     /db_xref="HGNC:HGNC:20155"
                     /db_xref="MIM:621023"
ORIGIN      
        1 mescsvtqag aqwrvlgslq ppppgfkqfl chslpsswdy rsdrmasddf divieamlea
       61 pykkeedeqq rkevkkdyps nttsstsnsg netsgsstig etskkkrsrs hnksrdrkrs
      121 rsrdrdryrr rnsrsrspgr qcrhrsrswd rrhgsesrsr dhrredrvhy rspplatgyr
      181 yghsksphfr ekspvrepvd nlspeerdar tvfcmqlaar irprdledff savgkvrdvr
      241 iisdrnsrrs kgiayvefce iqsvplaigl tgqrllgvpi ivqasqaekn rlaamannlq
      301 kgnggpmrly vgslhfnite dmlrgifepf gkidnivlmk dsdtgrskgy gfitlhpppl
      361 gtv
//
LOCUS       XP_011535205             269 aa            linear   PRI 05-AUG-2025
DEFINITION  putative RNA-binding protein 23 isoform X8 [Homo sapiens].
ACCESSION   XP_011535205
VERSION     XP_011535205.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536903.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..269
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..269
                     /product="putative RNA-binding protein 23 isoform X8"
                     /calculated_mol_wt=28506
     Region          <1..268
                     /region_name="SF-CC1"
                     /note="splicing factor, CC1-like family; TIGR01622"
                     /db_xref="CDD:273721"
     CDS             1..269
                     /gene="RBM23"
                     /gene_synonym="CAPERbeta; PP239; RNPC4"
                     /coded_by="XM_011536903.2:435..1244"
                     /db_xref="GeneID:55147"
                     /db_xref="HGNC:HGNC:20155"
                     /db_xref="MIM:621023"
ORIGIN      
        1 mqlaarirpr dledffsavg kvrdvriisd rnsrrskgia yvefceiqsv plaigltgqr
       61 llgvpiivqa sqaeknrlaa mannlqkgng gpmrlyvgsl hfnitedmlr gifepfgkid
      121 nivlmkdsdt grskgygfit fsdsecarra leqlngfela grpmrvghvt erldggtdit
      181 fpdgdqeldl gsaggrfqlm aklaegagiq lpstaaaaaa aaaqaaalql ngavplgaln
      241 paaltalspa lnlasqcfql sslftpqtm
//
LOCUS       XP_011535208             269 aa            linear   PRI 05-AUG-2025
DEFINITION  putative RNA-binding protein 23 isoform X8 [Homo sapiens].
ACCESSION   XP_011535208
VERSION     XP_011535208.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536906.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..269
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..269
                     /product="putative RNA-binding protein 23 isoform X8"
                     /calculated_mol_wt=28506
     Region          <1..268
                     /region_name="SF-CC1"
                     /note="splicing factor, CC1-like family; TIGR01622"
                     /db_xref="CDD:273721"
     CDS             1..269
                     /gene="RBM23"
                     /gene_synonym="CAPERbeta; PP239; RNPC4"
                     /coded_by="XM_011536906.2:381..1190"
                     /db_xref="GeneID:55147"
                     /db_xref="HGNC:HGNC:20155"
                     /db_xref="MIM:621023"
ORIGIN      
        1 mqlaarirpr dledffsavg kvrdvriisd rnsrrskgia yvefceiqsv plaigltgqr
       61 llgvpiivqa sqaeknrlaa mannlqkgng gpmrlyvgsl hfnitedmlr gifepfgkid
      121 nivlmkdsdt grskgygfit fsdsecarra leqlngfela grpmrvghvt erldggtdit
      181 fpdgdqeldl gsaggrfqlm aklaegagiq lpstaaaaaa aaaqaaalql ngavplgaln
      241 paaltalspa lnlasqcfql sslftpqtm
//
LOCUS       XP_047287477             269 aa            linear   PRI 05-AUG-2025
DEFINITION  putative RNA-binding protein 23 isoform X8 [Homo sapiens].
ACCESSION   XP_047287477
VERSION     XP_047287477.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431521.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 12% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..269
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..269
                     /product="putative RNA-binding protein 23 isoform X8"
                     /calculated_mol_wt=28506
     Region          <1..268
                     /region_name="SF-CC1"
                     /note="splicing factor, CC1-like family; TIGR01622"
                     /db_xref="CDD:273721"
     CDS             1..269
                     /gene="RBM23"
                     /gene_synonym="CAPERbeta; PP239; RNPC4"
                     /coded_by="XM_047431521.1:526..1335"
                     /db_xref="GeneID:55147"
                     /db_xref="HGNC:HGNC:20155"
                     /db_xref="MIM:621023"
ORIGIN      
        1 mqlaarirpr dledffsavg kvrdvriisd rnsrrskgia yvefceiqsv plaigltgqr
       61 llgvpiivqa sqaeknrlaa mannlqkgng gpmrlyvgsl hfnitedmlr gifepfgkid
      121 nivlmkdsdt grskgygfit fsdsecarra leqlngfela grpmrvghvt erldggtdit
      181 fpdgdqeldl gsaggrfqlm aklaegagiq lpstaaaaaa aaaqaaalql ngavplgaln
      241 paaltalspa lnlasqcfql sslftpqtm
//
LOCUS       XP_011535204             269 aa            linear   PRI 05-AUG-2025
DEFINITION  putative RNA-binding protein 23 isoform X8 [Homo sapiens].
ACCESSION   XP_011535204
VERSION     XP_011535204.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536902.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..269
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..269
                     /product="putative RNA-binding protein 23 isoform X8"
                     /calculated_mol_wt=28506
     Region          <1..268
                     /region_name="SF-CC1"
                     /note="splicing factor, CC1-like family; TIGR01622"
                     /db_xref="CDD:273721"
     CDS             1..269
                     /gene="RBM23"
                     /gene_synonym="CAPERbeta; PP239; RNPC4"
                     /coded_by="XM_011536902.2:559..1368"
                     /db_xref="GeneID:55147"
                     /db_xref="HGNC:HGNC:20155"
                     /db_xref="MIM:621023"
ORIGIN      
        1 mqlaarirpr dledffsavg kvrdvriisd rnsrrskgia yvefceiqsv plaigltgqr
       61 llgvpiivqa sqaeknrlaa mannlqkgng gpmrlyvgsl hfnitedmlr gifepfgkid
      121 nivlmkdsdt grskgygfit fsdsecarra leqlngfela grpmrvghvt erldggtdit
      181 fpdgdqeldl gsaggrfqlm aklaegagiq lpstaaaaaa aaaqaaalql ngavplgaln
      241 paaltalspa lnlasqcfql sslftpqtm
//
LOCUS       XP_047287478             337 aa            linear   PRI 05-AUG-2025
DEFINITION  factor associated with metabolism and energy isoform X1 [Homo
            sapiens].
ACCESSION   XP_047287478
VERSION     XP_047287478.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431522.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..337
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..337
                     /product="factor associated with metabolism and energy
                     isoform X1"
                     /calculated_mol_wt=38931
     Region          1..337
                     /region_name="DUF4619"
                     /note="Domain of unknown function (DUF4619); pfam15398"
                     /db_xref="CDD:464705"
     CDS             1..337
                     /gene="CCDC198"
                     /gene_synonym="C14orf105; FAME"
                     /coded_by="XM_047431522.1:143..1156"
                     /db_xref="GeneID:55195"
                     /db_xref="HGNC:HGNC:20189"
ORIGIN      
        1 mglshskthl rvikvaplqn kevetpsagr vdfafnqnle ektsyslarl qdqnkalegq
       61 lpplqenwyg rystasrdmy fdiplehret siikrhppqr lqklepidlp rvitsgrlls
      121 qreartmhka kqvlekkmqt pmytsenrqy lhkmqvlemi rkrqeaqmel kkslhgeari
      181 nkqsprdhka kktlqstprn ddhdlltmlp deilnrgpdr vslllprlec ngmisahrkl
      241 rlpssndspa sasrvagitg nsknteflkh qavnnycpwk igkmetwlhe qeaqgqllwd
      301 ssssdsdeqg kdekkpralv rtrteriplf deffdqe
//
LOCUS       XP_047287479             259 aa            linear   PRI 05-AUG-2025
DEFINITION  factor associated with metabolism and energy isoform X2 [Homo
            sapiens].
ACCESSION   XP_047287479
VERSION     XP_047287479.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431523.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 32% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..259
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..259
                     /product="factor associated with metabolism and energy
                     isoform X2"
                     /calculated_mol_wt=30089
     Region          <1..259
                     /region_name="DUF4619"
                     /note="Domain of unknown function (DUF4619); pfam15398"
                     /db_xref="CDD:464705"
     CDS             1..259
                     /gene="CCDC198"
                     /gene_synonym="C14orf105; FAME"
                     /coded_by="XM_047431523.1:357..1136"
                     /db_xref="GeneID:55195"
                     /db_xref="HGNC:HGNC:20189"
ORIGIN      
        1 myfdiplehr etsiikrhpp qrlqklepid lprvitsgrl lsqreartmh kakqvlekkm
       61 qtpmytsenr qylhkmqvle mirkrqeaqm elkkslhgea rinkqsprdh kakktlqstp
      121 rnddhdlltm lpdeilnrgp drvslllprl ecngmisahr klrlpssnds pasasrvagi
      181 tgnskntefl khqavnnycp wkigkmetwl heqeaqgqll wdssssdsde qgkdekkpra
      241 lvrtrterip lfdeffdqe
//
LOCUS       XP_047287480             249 aa            linear   PRI 05-AUG-2025
DEFINITION  factor associated with metabolism and energy isoform X3 [Homo
            sapiens].
ACCESSION   XP_047287480
VERSION     XP_047287480.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431524.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..249
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..249
                     /product="factor associated with metabolism and energy
                     isoform X3"
                     /calculated_mol_wt=28811
     Region          <15..249
                     /region_name="DUF4619"
                     /note="Domain of unknown function (DUF4619); pfam15398"
                     /db_xref="CDD:464705"
     CDS             1..249
                     /gene="CCDC198"
                     /gene_synonym="C14orf105; FAME"
                     /coded_by="XM_047431524.1:49..798"
                     /db_xref="GeneID:55195"
                     /db_xref="HGNC:HGNC:20189"
ORIGIN      
        1 mnlkgfirnf ldkmklepid lprvitsgrl lsqreartmh kakqvlekkm qtpmytsenr
       61 qylhkmqvle mirkrqeaqm elkkslhgea rinkqsprdh kakktlqstp rnddhdlltm
      121 lpdeilnrgp drvslllprl ecngmisahr klrlpssnds pasasrvagi tgnskntefl
      181 khqavnnycp wkigkmetwl heqeaqgqll wdssssdsde qgkdekkpra lvrtrterip
      241 lfdeffdqe
//
LOCUS       XP_047287481             235 aa            linear   PRI 05-AUG-2025
DEFINITION  factor associated with metabolism and energy isoform X4 [Homo
            sapiens].
ACCESSION   XP_047287481
VERSION     XP_047287481.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431525.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..235
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..235
                     /product="factor associated with metabolism and energy
                     isoform X4"
                     /calculated_mol_wt=27141
     Region          1..>218
                     /region_name="DUF4619"
                     /note="Domain of unknown function (DUF4619); pfam15398"
                     /db_xref="CDD:464705"
     CDS             1..235
                     /gene="CCDC198"
                     /gene_synonym="C14orf105; FAME"
                     /coded_by="XM_047431525.1:143..850"
                     /db_xref="GeneID:55195"
                     /db_xref="HGNC:HGNC:20189"
ORIGIN      
        1 mglshskthl rvikvaplqn kevetpsagr vdfafnqnle ektsyslarl qdqnkalegq
       61 lpplqenwyg rystasrdmy fdiplehret siikrhppqr lqklepidlp rvitsgrlls
      121 qreartmhka kqvlekkmqt pmytsenrqy lhkmqvlemi rkrqeaqmel kkslhgeari
      181 nkqsprdhka kktlqstprn ddhdlltmlp deilnrgpdr cavgqiptsa glthr
//
LOCUS       XP_047287482             234 aa            linear   PRI 05-AUG-2025
DEFINITION  factor associated with metabolism and energy isoform X5 [Homo
            sapiens].
ACCESSION   XP_047287482
VERSION     XP_047287482.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431526.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..234
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..234
                     /product="factor associated with metabolism and energy
                     isoform X5"
                     /calculated_mol_wt=27013
     Region          1..>217
                     /region_name="DUF4619"
                     /note="Domain of unknown function (DUF4619); pfam15398"
                     /db_xref="CDD:464705"
     CDS             1..234
                     /gene="CCDC198"
                     /gene_synonym="C14orf105; FAME"
                     /coded_by="XM_047431526.1:143..847"
                     /db_xref="GeneID:55195"
                     /db_xref="HGNC:HGNC:20189"
ORIGIN      
        1 mglshskthl rvikvaplqn kevetpsagr vdfafnqnle ektsyslarl qdqnkalegq
       61 lpplqenwyg rystasrdmy fdiplehret siikrhppqr lqklepidlp rvitsgrlls
      121 qreartmhka kvlekkmqtp mytsenrqyl hkmqvlemir krqeaqmelk kslhgearin
      181 kqsprdhkak ktlqstprnd dhdlltmlpd eilnrgpdrc avgqiptsag lthr
//
LOCUS       XP_047287483             223 aa            linear   PRI 05-AUG-2025
DEFINITION  factor associated with metabolism and energy isoform X6 [Homo
            sapiens].
ACCESSION   XP_047287483
VERSION     XP_047287483.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431527.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..223
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..223
                     /product="factor associated with metabolism and energy
                     isoform X6"
                     /calculated_mol_wt=25888
     Region          1..>219
                     /region_name="DUF4619"
                     /note="Domain of unknown function (DUF4619); pfam15398"
                     /db_xref="CDD:464705"
     CDS             1..223
                     /gene="CCDC198"
                     /gene_synonym="C14orf105; FAME"
                     /coded_by="XM_047431527.1:143..814"
                     /db_xref="GeneID:55195"
                     /db_xref="HGNC:HGNC:20189"
ORIGIN      
        1 mglshskthl rvikvaplqn kevetpsagr vdfafnqnle ektsyslarl qdqnkalegq
       61 lpplqenwyg rystasrdmy fdiplehret siikrhppqr lqklepidlp rvitsgrlls
      121 qreartmhka kqvlekkmqt pmytsenrqy lhkmqvlemi rkrqeaqmel kkslhgeari
      181 nkqsprdhka kktlqstprn ddhdlltmlp deilnrgpgq ths
//
LOCUS       XP_047287484             222 aa            linear   PRI 05-AUG-2025
DEFINITION  factor associated with metabolism and energy isoform X7 [Homo
            sapiens].
ACCESSION   XP_047287484
VERSION     XP_047287484.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431528.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..222
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..222
                     /product="factor associated with metabolism and energy
                     isoform X7"
                     /calculated_mol_wt=25760
     Region          1..>218
                     /region_name="DUF4619"
                     /note="Domain of unknown function (DUF4619); pfam15398"
                     /db_xref="CDD:464705"
     CDS             1..222
                     /gene="CCDC198"
                     /gene_synonym="C14orf105; FAME"
                     /coded_by="XM_047431528.1:143..811"
                     /db_xref="GeneID:55195"
                     /db_xref="HGNC:HGNC:20189"
ORIGIN      
        1 mglshskthl rvikvaplqn kevetpsagr vdfafnqnle ektsyslarl qdqnkalegq
       61 lpplqenwyg rystasrdmy fdiplehret siikrhppqr lqklepidlp rvitsgrlls
      121 qreartmhka kvlekkmqtp mytsenrqyl hkmqvlemir krqeaqmelk kslhgearin
      181 kqsprdhkak ktlqstprnd dhdlltmlpd eilnrgpgqt hs
//
LOCUS       XP_047287485             211 aa            linear   PRI 05-AUG-2025
DEFINITION  factor associated with metabolism and energy isoform X8 [Homo
            sapiens].
ACCESSION   XP_047287485
VERSION     XP_047287485.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431529.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..211
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..211
                     /product="factor associated with metabolism and energy
                     isoform X8"
                     /calculated_mol_wt=24371
     Region          <1..211
                     /region_name="DUF4619"
                     /note="Domain of unknown function (DUF4619); pfam15398"
                     /db_xref="CDD:464705"
     CDS             1..211
                     /gene="CCDC198"
                     /gene_synonym="C14orf105; FAME"
                     /coded_by="XM_047431529.1:194..829"
                     /db_xref="GeneID:55195"
                     /db_xref="HGNC:HGNC:20189"
ORIGIN      
        1 mhkakqvlek kmqtpmytse nrqylhkmqv lemirkrqea qmelkkslhg earinkqspr
       61 dhkakktlqs tprnddhdll tmlpdeilnr gpdrvslllp rlecngmisa hrklrlpssn
      121 dspasasrva gitgnsknte flkhqavnny cpwkigkmet wlheqeaqgq llwdssssds
      181 deqgkdekkp ralvrtrter iplfdeffdq e
//
LOCUS       XP_005267868             208 aa            linear   PRI 05-AUG-2025
DEFINITION  factor associated with metabolism and energy isoform X9 [Homo
            sapiens].
ACCESSION   XP_005267868
VERSION     XP_005267868.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267811.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..208
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..208
                     /product="factor associated with metabolism and energy
                     isoform X9"
                     /calculated_mol_wt=24439
     Region          <15..208
                     /region_name="DUF4619"
                     /note="Domain of unknown function (DUF4619); pfam15398"
                     /db_xref="CDD:464705"
     CDS             1..208
                     /gene="CCDC198"
                     /gene_synonym="C14orf105; FAME"
                     /coded_by="XM_005267811.4:84..710"
                     /db_xref="GeneID:55195"
                     /db_xref="HGNC:HGNC:20189"
ORIGIN      
        1 mnlkgfirnf ldkmklepid lprvitsgrl lsqreartmh kakqvlekkm qtpmytsenr
       61 qylhkmqvle mirkrqeaqm elkkslhgea rinkqsprdh kakktlqstp rnddhdlltm
      121 lpdeilnrgp gnsknteflk hqavnnycpw kigkmetwlh eqeaqgqllw dssssdsdeq
      181 gkdekkpral vrtrteripl fdeffdqe
//
LOCUS       XP_011535210             496 aa            linear   PRI 05-AUG-2025
DEFINITION  exonuclease 3'-5' domain-containing protein 2 isoform X1 [Homo
            sapiens].
ACCESSION   XP_011535210
VERSION     XP_011535210.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536908.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..496
                     /product="exonuclease 3'-5' domain-containing protein 2
                     isoform X1"
                     /calculated_mol_wt=56215
     Region          <1..133
                     /region_name="WRN_exo"
                     /note="DEDDy 3'-5' exonuclease domain of WRN and similar
                     proteins; cd06141"
                     /db_xref="CDD:176653"
     CDS             1..496
                     /gene="EXD2"
                     /gene_synonym="C14orf114; EXDL2"
                     /coded_by="XM_011536908.4:312..1802"
                     /db_xref="GeneID:55218"
                     /db_xref="HGNC:HGNC:20217"
                     /db_xref="MIM:616940"
ORIGIN      
        1 maspsglcvl vrlpklicgg ktlprtlldi ladgtilkvg vgcsedaskl lqdyglvvrg
       61 cldlrylamr qrnnllcngl slkslaetvl nfpldkslll rcsnwdaetl tedqviyaar
      121 daqisvalfl hllgypfsrn spgeknddhs swrkvlekcq gvvdipfrsk gmsrlgeevn
      181 geatesqqkp rnkkskmdgm vpgnhqgrdp rkhkrkplgv gysarksply dncflhapdg
      241 qplctcdrrk aqwyldkgig elvseepfvv klrfepagrp espgdyylmv kenlcvvcgk
      301 rdsyirknvi pheyrkhfpi emkdhnshdv lllctschai snyydnhlkq qlakefqapi
      361 gseeglrlle dperrqvrsg arallnaesl ptqrkeellq alrefyntdv vteemlqeaa
      421 sletrisnen yvphglkvvq chsqgglrsl mqlesrwrqh fldsmqpkhl pqqwsvdhnh
      481 qkllrkfged lpiqls
//
LOCUS       XP_016876910             496 aa            linear   PRI 05-AUG-2025
DEFINITION  exonuclease 3'-5' domain-containing protein 2 isoform X1 [Homo
            sapiens].
ACCESSION   XP_016876910
VERSION     XP_016876910.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021421.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..496
                     /product="exonuclease 3'-5' domain-containing protein 2
                     isoform X1"
                     /calculated_mol_wt=56215
     Region          <1..133
                     /region_name="WRN_exo"
                     /note="DEDDy 3'-5' exonuclease domain of WRN and similar
                     proteins; cd06141"
                     /db_xref="CDD:176653"
     CDS             1..496
                     /gene="EXD2"
                     /gene_synonym="C14orf114; EXDL2"
                     /coded_by="XM_017021421.3:221..1711"
                     /db_xref="GeneID:55218"
                     /db_xref="HGNC:HGNC:20217"
                     /db_xref="MIM:616940"
ORIGIN      
        1 maspsglcvl vrlpklicgg ktlprtlldi ladgtilkvg vgcsedaskl lqdyglvvrg
       61 cldlrylamr qrnnllcngl slkslaetvl nfpldkslll rcsnwdaetl tedqviyaar
      121 daqisvalfl hllgypfsrn spgeknddhs swrkvlekcq gvvdipfrsk gmsrlgeevn
      181 geatesqqkp rnkkskmdgm vpgnhqgrdp rkhkrkplgv gysarksply dncflhapdg
      241 qplctcdrrk aqwyldkgig elvseepfvv klrfepagrp espgdyylmv kenlcvvcgk
      301 rdsyirknvi pheyrkhfpi emkdhnshdv lllctschai snyydnhlkq qlakefqapi
      361 gseeglrlle dperrqvrsg arallnaesl ptqrkeellq alrefyntdv vteemlqeaa
      421 sletrisnen yvphglkvvq chsqgglrsl mqlesrwrqh fldsmqpkhl pqqwsvdhnh
      481 qkllrkfged lpiqls
//
LOCUS       XP_005267874             496 aa            linear   PRI 05-AUG-2025
DEFINITION  exonuclease 3'-5' domain-containing protein 2 isoform X1 [Homo
            sapiens].
ACCESSION   XP_005267874
VERSION     XP_005267874.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267817.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..496
                     /product="exonuclease 3'-5' domain-containing protein 2
                     isoform X1"
                     /calculated_mol_wt=56215
     Region          <1..133
                     /region_name="WRN_exo"
                     /note="DEDDy 3'-5' exonuclease domain of WRN and similar
                     proteins; cd06141"
                     /db_xref="CDD:176653"
     CDS             1..496
                     /gene="EXD2"
                     /gene_synonym="C14orf114; EXDL2"
                     /coded_by="XM_005267817.5:88..1578"
                     /db_xref="GeneID:55218"
                     /db_xref="HGNC:HGNC:20217"
                     /db_xref="MIM:616940"
ORIGIN      
        1 maspsglcvl vrlpklicgg ktlprtlldi ladgtilkvg vgcsedaskl lqdyglvvrg
       61 cldlrylamr qrnnllcngl slkslaetvl nfpldkslll rcsnwdaetl tedqviyaar
      121 daqisvalfl hllgypfsrn spgeknddhs swrkvlekcq gvvdipfrsk gmsrlgeevn
      181 geatesqqkp rnkkskmdgm vpgnhqgrdp rkhkrkplgv gysarksply dncflhapdg
      241 qplctcdrrk aqwyldkgig elvseepfvv klrfepagrp espgdyylmv kenlcvvcgk
      301 rdsyirknvi pheyrkhfpi emkdhnshdv lllctschai snyydnhlkq qlakefqapi
      361 gseeglrlle dperrqvrsg arallnaesl ptqrkeellq alrefyntdv vteemlqeaa
      421 sletrisnen yvphglkvvq chsqgglrsl mqlesrwrqh fldsmqpkhl pqqwsvdhnh
      481 qkllrkfged lpiqls
//
LOCUS       XP_011535213             702 aa            linear   PRI 05-AUG-2025
DEFINITION  vertnin isoform X1 [Homo sapiens].
ACCESSION   XP_011535213
VERSION     XP_011535213.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536911.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..702
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..702
                     /product="vertnin isoform X1"
                     /calculated_mol_wt=78129
     Region          74..241
                     /region_name="OTU_VRTN"
                     /note="OTU (ovarian tumor) domain of vertnin and similar
                     proteins; cd22791"
                     /db_xref="CDD:438612"
     Site            order(85,160,163,170..173,198,200,210,212..213)
                     /site_type="other"
                     /note="putative polypeptide substrate binding site
                     [polypeptide binding]"
                     /db_xref="CDD:438612"
     Region          <276..>312
                     /region_name="InsE"
                     /note="Transposase InsE and inactivated derivatives
                     [Mobilome: prophages, transposons]; COG2963"
                     /db_xref="CDD:442203"
     CDS             1..702
                     /gene="VRTN"
                     /gene_synonym="C14orf115; vertnin"
                     /coded_by="XM_011536911.3:322..2430"
                     /db_xref="GeneID:55237"
                     /db_xref="HGNC:HGNC:20223"
                     /db_xref="MIM:620468"
ORIGIN      
        1 mtsrnqlvqk vlqelqeave ceglegliga sleakqvlss ftlptcregg pglqvlevds
       61 valslypeda prnmlplvck gegsllfeaa smllwgdagl slelrartvv emllhrhyyl
      121 qgmidskvml qavryslcse espemtslpp atleaifdad vkascfpssf snvwhlyala
      181 svlqrniysi ypmrnlkirp yfnrvirprr cdhvpstlhi mwagqpltsh ffrhqyfapv
      241 vgleeveaeg apgvapalpa laplsspakt lellnrepgl syshlcerys vtkstfyrwr
      301 rqsqehrqkv aarfsakhfl qdsfhrggvv plqqflqrfp eisrstyyaw khellgsgtc
      361 palpprevlg meeleklpee qvaeeelecs alavsspgmv lmqraklyle hcislntlvp
      421 yrcfkrrfpg isrstyynwr rkalrrnpsf kpapalsaag tpqlasvgeg avipwkseae
      481 egagnatged ppapgellpl rmplsrwqrr lrraarrqvl sghlpfcrfr lrypslspsa
      541 fwvwkslarg wprglsklqv pvptlgkggq eaeekqekea grdvtavmap pvgassedve
      601 ggpsregalq egataqgqph sgpllsqpvv aaaggrdgrm lvmdmiattk fkaqaklflq
      661 krfqsksfps ykefsalfpl tarstyymwk ralydgltlv dg
//
LOCUS       XP_005267876             584 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
            gamma isoform isoform X1 [Homo sapiens].
ACCESSION   XP_005267876
VERSION     XP_005267876.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267819.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..584
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..584
                     /product="serine/threonine-protein phosphatase 2A 56 kDa
                     regulatory subunit gamma isoform isoform X1"
                     /calculated_mol_wt=67484
     Region          94..497
                     /region_name="B56"
                     /note="Protein phosphatase 2A regulatory B subunit (B56
                     family); pfam01603"
                     /db_xref="CDD:460264"
     CDS             1..584
                     /gene="PPP2R5C"
                     /gene_synonym="B56G; B56gamma; HJS4; PR61G"
                     /coded_by="XM_005267819.2:113..1867"
                     /db_xref="GeneID:5527"
                     /db_xref="HGNC:HGNC:9311"
                     /db_xref="MIM:601645"
ORIGIN      
        1 mggtsreelr kaelespkag ksgksskegq dtveseqisv rknslvavps tvsakikvpv
       61 sqpivkkdkr qnssrfsasn nrelqklpsl kdvppadqek lfiqklrqcc vlfdfvsdpl
      121 sdlkwkevkr aalsemveyi thnrnvitep iypevvhmfa vnmfrtlpps snptgaefdp
      181 eedeptleaa wphlqlvyef flrflespdf qpniakkyid qkfvlqllel fdsedprerd
      241 flkttlhriy gkflglrayi rkqinnifyr fiyetehhng iaelleilgs iingfalplk
      301 eehkifllkv llplhkvksl svyhpqlayc vvqflekdst ltepvvmall kywpkthspk
      361 evmflnelee ildviepsef vkimeplfrq lakcvssphf qvaeralyyw nneyimslis
      421 dnaakilpim fpslyrnskt hwnktihgli ynalklfmem nqklfddctq qfkaeklkek
      481 lkmkereeaw vkienlakan pqytvysqas tmsipvamet dgplfedvqm lrktvkdeah
      541 qaqkdpkkdr plarrkselp qdphtkkale ahcradelas qdgr
//
LOCUS       XP_047287486             542 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
            gamma isoform isoform X2 [Homo sapiens].
ACCESSION   XP_047287486
VERSION     XP_047287486.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431530.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..542
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..542
                     /product="serine/threonine-protein phosphatase 2A 56 kDa
                     regulatory subunit gamma isoform isoform X2"
                     /calculated_mol_wt=62868
     Region          52..455
                     /region_name="B56"
                     /note="Protein phosphatase 2A regulatory B subunit (B56
                     family); pfam01603"
                     /db_xref="CDD:460264"
     CDS             1..542
                     /gene="PPP2R5C"
                     /gene_synonym="B56G; B56gamma; HJS4; PR61G"
                     /coded_by="XM_047431530.1:149..1777"
                     /db_xref="GeneID:5527"
                     /db_xref="HGNC:HGNC:9311"
                     /db_xref="MIM:601645"
ORIGIN      
        1 mrptpmglss pwsfsifegt speepsspkv pppllpellv lifgglqgrd vppadqeklf
       61 iqklrqccvl fdfvsdplsd lkwkevkraa lsemveyith nrnvitepiy pevvhmfavn
      121 mfrtlppssn ptgaefdpee deptleaawp hlqlvyeffl rflespdfqp niakkyidqk
      181 fvlqllelfd sedprerdfl kttlhriygk flglrayirk qinnifyrfi yetehhngia
      241 elleilgsii ngfalplkee hkifllkvll plhkvkslsv yhpqlaycvv qflekdstlt
      301 epvvmallky wpkthspkev mflneleeil dviepsefvk imeplfrqla kcvssphfqv
      361 aeralyywnn eyimslisdn aakilpimfp slyrnskthw nktihgliyn alklfmemnq
      421 klfddctqqf kaeklkeklk mkereeawvk ienlakanpq ytvysqastm sipvametdg
      481 plfedvqmlr ktvkdeahqa qkdpkkdrpl arrkselpqd phtkkaleah cradelasqd
      541 gr
//
LOCUS       XP_005267881             539 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
            gamma isoform isoform X3 [Homo sapiens].
ACCESSION   XP_005267881
VERSION     XP_005267881.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267824.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..539
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..539
                     /product="serine/threonine-protein phosphatase 2A 56 kDa
                     regulatory subunit gamma isoform isoform X3"
                     /calculated_mol_wt=62017
     Region          94..481
                     /region_name="B56"
                     /note="Protein phosphatase 2A regulatory B subunit (B56
                     family); pfam01603"
                     /db_xref="CDD:460264"
     CDS             1..539
                     /gene="PPP2R5C"
                     /gene_synonym="B56G; B56gamma; HJS4; PR61G"
                     /coded_by="XM_005267824.2:113..1732"
                     /db_xref="GeneID:5527"
                     /db_xref="HGNC:HGNC:9311"
                     /db_xref="MIM:601645"
ORIGIN      
        1 mggtsreelr kaelespkag ksgksskegq dtveseqisv rknslvavps tvsakikvpv
       61 sqpivkkdkr qnssrfsasn nrelqklpsl kdvppadqek lfiqklrqcc vlfdfvsdpl
      121 sdlkwkevkr aalsemveyi thnrnvitep iypevvhmfa vnmfrtlpps snptgaefdp
      181 eedeptleaa wphlqlvyef flrflespdf qpniakkyid qkfvlqllel fdsedprerd
      241 flkttlhriy gkflglrayi rkqinnifyr fiyetehhng iaelleilgs iingfalplk
      301 eehkifllkv llplhkvksl svyhpqlayc vvqflekdst ltepvvmall kywpkthspk
      361 evmflnelee ildviepsef vkimeplfrq lakcvssphf qvaeralyyw nneyimslis
      421 dnaakilpim fpslyrnskt hwnktihgli ynalklfmem nqklfddctq qfkaeklkhr
      481 kirrrtvllh aaspsclrtp tprkpwklta gpmswpprta aslrgaasgp gppvlfril
//
LOCUS       XP_047287487             515 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
            gamma isoform isoform X4 [Homo sapiens].
ACCESSION   XP_047287487
VERSION     XP_047287487.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431531.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..515
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..515
                     /product="serine/threonine-protein phosphatase 2A 56 kDa
                     regulatory subunit gamma isoform isoform X4"
                     /calculated_mol_wt=60499
     Region          25..428
                     /region_name="B56"
                     /note="Protein phosphatase 2A regulatory B subunit (B56
                     family); pfam01603"
                     /db_xref="CDD:460264"
     CDS             1..515
                     /gene="PPP2R5C"
                     /gene_synonym="B56G; B56gamma; HJS4; PR61G"
                     /coded_by="XM_047431531.1:371..1918"
                     /db_xref="GeneID:5527"
                     /db_xref="HGNC:HGNC:9311"
                     /db_xref="MIM:601645"
ORIGIN      
        1 mfklhfrhsw qeyfrgkrkl tidvppadqe klfiqklrqc cvlfdfvsdp lsdlkwkevk
       61 raalsemvey ithnrnvite piypevvhmf avnmfrtlpp ssnptgaefd peedeptlea
      121 awphlqlvye fflrflespd fqpniakkyi dqkfvlqlle lfdsedprer dflkttlhri
      181 ygkflglray irkqinnify rfiyetehhn giaelleilg siingfalpl keehkifllk
      241 vllplhkvks lsvyhpqlay cvvqflekds tltepvvmal lkywpkthsp kevmflnele
      301 eildviepse fvkimeplfr qlakcvssph fqvaeralyy wnneyimsli sdnaakilpi
      361 mfpslyrnsk thwnktihgl iynalklfme mnqklfddct qqfkaeklke klkmkereea
      421 wvkienlaka npqytvysqa stmsipvame tdgplfedvq mlrktvkdea hqaqkdpkkd
      481 rplarrksel pqdphtkkal eahcradela sqdgr
//
LOCUS       XP_047287488             515 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
            gamma isoform isoform X4 [Homo sapiens].
ACCESSION   XP_047287488
VERSION     XP_047287488.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431532.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..515
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..515
                     /product="serine/threonine-protein phosphatase 2A 56 kDa
                     regulatory subunit gamma isoform isoform X4"
                     /calculated_mol_wt=60499
     Region          25..428
                     /region_name="B56"
                     /note="Protein phosphatase 2A regulatory B subunit (B56
                     family); pfam01603"
                     /db_xref="CDD:460264"
     CDS             1..515
                     /gene="PPP2R5C"
                     /gene_synonym="B56G; B56gamma; HJS4; PR61G"
                     /coded_by="XM_047431532.1:431..1978"
                     /db_xref="GeneID:5527"
                     /db_xref="HGNC:HGNC:9311"
                     /db_xref="MIM:601645"
ORIGIN      
        1 mfklhfrhsw qeyfrgkrkl tidvppadqe klfiqklrqc cvlfdfvsdp lsdlkwkevk
       61 raalsemvey ithnrnvite piypevvhmf avnmfrtlpp ssnptgaefd peedeptlea
      121 awphlqlvye fflrflespd fqpniakkyi dqkfvlqlle lfdsedprer dflkttlhri
      181 ygkflglray irkqinnify rfiyetehhn giaelleilg siingfalpl keehkifllk
      241 vllplhkvks lsvyhpqlay cvvqflekds tltepvvmal lkywpkthsp kevmflnele
      301 eildviepse fvkimeplfr qlakcvssph fqvaeralyy wnneyimsli sdnaakilpi
      361 mfpslyrnsk thwnktihgl iynalklfme mnqklfddct qqfkaeklke klkmkereea
      421 wvkienlaka npqytvysqa stmsipvame tdgplfedvq mlrktvkdea hqaqkdpkkd
      481 rplarrksel pqdphtkkal eahcradela sqdgr
//
LOCUS       XP_011535220             508 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
            gamma isoform isoform X5 [Homo sapiens].
ACCESSION   XP_011535220
VERSION     XP_011535220.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536918.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..508
                     /product="serine/threonine-protein phosphatase 2A 56 kDa
                     regulatory subunit gamma isoform isoform X5"
                     /calculated_mol_wt=59702
     Region          18..421
                     /region_name="B56"
                     /note="Protein phosphatase 2A regulatory B subunit (B56
                     family); pfam01603"
                     /db_xref="CDD:460264"
     CDS             1..508
                     /gene="PPP2R5C"
                     /gene_synonym="B56G; B56gamma; HJS4; PR61G"
                     /coded_by="XM_011536918.2:371..1897"
                     /db_xref="GeneID:5527"
                     /db_xref="HGNC:HGNC:9311"
                     /db_xref="MIM:601645"
ORIGIN      
        1 mfklhfrhsw qeyfrdvppa dqeklfiqkl rqccvlfdfv sdplsdlkwk evkraalsem
       61 veyithnrnv itepiypevv hmfavnmfrt lppssnptga efdpeedept leaawphlql
      121 vyefflrfle spdfqpniak kyidqkfvlq llelfdsedp rerdflkttl hriygkflgl
      181 rayirkqinn ifyrfiyete hhngiaelle ilgsiingfa lplkeehkif llkvllplhk
      241 vkslsvyhpq laycvvqfle kdstltepvv mallkywpkt hspkevmfln eleeildvie
      301 psefvkimep lfrqlakcvs sphfqvaera lyywnneyim slisdnaaki lpimfpslyr
      361 nskthwnkti hgliynalkl fmemnqklfd dctqqfkaek lkeklkmker eeawvkienl
      421 akanpqytvy sqastmsipv ametdgplfe dvqmlrktvk deahqaqkdp kkdrplarrk
      481 selpqdphtk kaleahcrad elasqdgr
//
LOCUS       XP_005267883             500 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
            gamma isoform isoform X6 [Homo sapiens].
ACCESSION   XP_005267883
VERSION     XP_005267883.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267826.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..500
                     /product="serine/threonine-protein phosphatase 2A 56 kDa
                     regulatory subunit gamma isoform isoform X6"
                     /calculated_mol_wt=58417
     Region          10..413
                     /region_name="B56"
                     /note="Protein phosphatase 2A regulatory B subunit (B56
                     family); pfam01603"
                     /db_xref="CDD:460264"
     CDS             1..500
                     /gene="PPP2R5C"
                     /gene_synonym="B56G; B56gamma; HJS4; PR61G"
                     /coded_by="XM_005267826.2:299..1801"
                     /db_xref="GeneID:5527"
                     /db_xref="HGNC:HGNC:9311"
                     /db_xref="MIM:601645"
ORIGIN      
        1 mqilghedvp padqeklfiq klrqccvlfd fvsdplsdlk wkevkraals emveyithnr
       61 nvitepiype vvhmfavnmf rtlppssnpt gaefdpeede ptleaawphl qlvyefflrf
      121 lespdfqpni akkyidqkfv lqllelfdse dprerdflkt tlhriygkfl glrayirkqi
      181 nnifyrfiye tehhngiael leilgsiing falplkeehk ifllkvllpl hkvkslsvyh
      241 pqlaycvvqf lekdstltep vvmallkywp kthspkevmf lneleeildv iepsefvkim
      301 eplfrqlakc vssphfqvae ralyywnney imslisdnaa kilpimfpsl yrnskthwnk
      361 tihgliynal klfmemnqkl fddctqqfka eklkeklkmk ereeawvkie nlakanpqyt
      421 vysqastmsi pvametdgpl fedvqmlrkt vkdeahqaqk dpkkdrplar rkselpqdph
      481 tkkaleahcr adelasqdgr
//
LOCUS       XP_047287489             503 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
            gamma isoform isoform X7 [Homo sapiens].
ACCESSION   XP_047287489
VERSION     XP_047287489.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431533.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..503
                     /product="serine/threonine-protein phosphatase 2A 56 kDa
                     regulatory subunit gamma isoform isoform X7"
                     /calculated_mol_wt=58468
     Region          52..455
                     /region_name="B56"
                     /note="Protein phosphatase 2A regulatory B subunit (B56
                     family); pfam01603"
                     /db_xref="CDD:460264"
     CDS             1..503
                     /gene="PPP2R5C"
                     /gene_synonym="B56G; B56gamma; HJS4; PR61G"
                     /coded_by="XM_047431533.1:149..1660"
                     /db_xref="GeneID:5527"
                     /db_xref="HGNC:HGNC:9311"
                     /db_xref="MIM:601645"
ORIGIN      
        1 mrptpmglss pwsfsifegt speepsspkv pppllpellv lifgglqgrd vppadqeklf
       61 iqklrqccvl fdfvsdplsd lkwkevkraa lsemveyith nrnvitepiy pevvhmfavn
      121 mfrtlppssn ptgaefdpee deptleaawp hlqlvyeffl rflespdfqp niakkyidqk
      181 fvlqllelfd sedprerdfl kttlhriygk flglrayirk qinnifyrfi yetehhngia
      241 elleilgsii ngfalplkee hkifllkvll plhkvkslsv yhpqlaycvv qflekdstlt
      301 epvvmallky wpkthspkev mflneleeil dviepsefvk imeplfrqla kcvssphfqv
      361 aeralyywnn eyimslisdn aakilpimfp slyrnskthw nktihgliyn alklfmemnq
      421 klfddctqqf kaeklkeklk mkereeawvk ienlakanpq aqkdpkkdrp larrkselpq
      481 dphtkkalea hcradelasq dgr
//
LOCUS       XP_047287490             497 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
            gamma isoform isoform X8 [Homo sapiens].
ACCESSION   XP_047287490
VERSION     XP_047287490.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431534.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..497
                     /product="serine/threonine-protein phosphatase 2A 56 kDa
                     regulatory subunit gamma isoform isoform X8"
                     /calculated_mol_wt=57401
     Region          52..439
                     /region_name="B56"
                     /note="Protein phosphatase 2A regulatory B subunit (B56
                     family); pfam01603"
                     /db_xref="CDD:460264"
     CDS             1..497
                     /gene="PPP2R5C"
                     /gene_synonym="B56G; B56gamma; HJS4; PR61G"
                     /coded_by="XM_047431534.1:149..1642"
                     /db_xref="GeneID:5527"
                     /db_xref="HGNC:HGNC:9311"
                     /db_xref="MIM:601645"
ORIGIN      
        1 mrptpmglss pwsfsifegt speepsspkv pppllpellv lifgglqgrd vppadqeklf
       61 iqklrqccvl fdfvsdplsd lkwkevkraa lsemveyith nrnvitepiy pevvhmfavn
      121 mfrtlppssn ptgaefdpee deptleaawp hlqlvyeffl rflespdfqp niakkyidqk
      181 fvlqllelfd sedprerdfl kttlhriygk flglrayirk qinnifyrfi yetehhngia
      241 elleilgsii ngfalplkee hkifllkvll plhkvkslsv yhpqlaycvv qflekdstlt
      301 epvvmallky wpkthspkev mflneleeil dviepsefvk imeplfrqla kcvssphfqv
      361 aeralyywnn eyimslisdn aakilpimfp slyrnskthw nktihgliyn alklfmemnq
      421 klfddctqqf kaeklkhrki rrrtvllhaa spsclrtptp rkpwkltagp mswpprtaas
      481 lrgaasgpgp pvlfril
//
LOCUS       XP_016876912             479 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
            gamma isoform isoform X9 [Homo sapiens].
ACCESSION   XP_016876912
VERSION     XP_016876912.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021423.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..479
                     /product="serine/threonine-protein phosphatase 2A 56 kDa
                     regulatory subunit gamma isoform isoform X9"
                     /calculated_mol_wt=55463
     Region          34..421
                     /region_name="B56"
                     /note="Protein phosphatase 2A regulatory B subunit (B56
                     family); pfam01603"
                     /db_xref="CDD:460264"
     CDS             1..479
                     /gene="PPP2R5C"
                     /gene_synonym="B56G; B56gamma; HJS4; PR61G"
                     /coded_by="XM_017021423.3:109..1548"
                     /db_xref="GeneID:5527"
                     /db_xref="HGNC:HGNC:9311"
                     /db_xref="MIM:601645"
ORIGIN      
        1 mltcnkagsr mvvdaansng pfqpvvllhi rdvppadqek lfiqklrqcc vlfdfvsdpl
       61 sdlkwkevkr aalsemveyi thnrnvitep iypevvhmfa vnmfrtlpps snptgaefdp
      121 eedeptleaa wphlqlvyef flrflespdf qpniakkyid qkfvlqllel fdsedprerd
      181 flkttlhriy gkflglrayi rkqinnifyr fiyetehhng iaelleilgs iingfalplk
      241 eehkifllkv llplhkvksl svyhpqlayc vvqflekdst ltepvvmall kywpkthspk
      301 evmflnelee ildviepsef vkimeplfrq lakcvssphf qvaeralyyw nneyimslis
      361 dnaakilpim fpslyrnskt hwnktihgli ynalklfmem nqklfddctq qfkaeklkhr
      421 kirrrtvllh aaspsclrtp tprkpwklta gpmswpprta aslrgaasgp gppvlfril
//
LOCUS       XP_047287491             463 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
            gamma isoform isoform X10 [Homo sapiens].
ACCESSION   XP_047287491
VERSION     XP_047287491.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431535.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..463
                     /product="serine/threonine-protein phosphatase 2A 56 kDa
                     regulatory subunit gamma isoform isoform X10"
                     /calculated_mol_wt=54236
     Region          18..405
                     /region_name="B56"
                     /note="Protein phosphatase 2A regulatory B subunit (B56
                     family); pfam01603"
                     /db_xref="CDD:460264"
     CDS             1..463
                     /gene="PPP2R5C"
                     /gene_synonym="B56G; B56gamma; HJS4; PR61G"
                     /coded_by="XM_047431535.1:371..1762"
                     /db_xref="GeneID:5527"
                     /db_xref="HGNC:HGNC:9311"
                     /db_xref="MIM:601645"
ORIGIN      
        1 mfklhfrhsw qeyfrdvppa dqeklfiqkl rqccvlfdfv sdplsdlkwk evkraalsem
       61 veyithnrnv itepiypevv hmfavnmfrt lppssnptga efdpeedept leaawphlql
      121 vyefflrfle spdfqpniak kyidqkfvlq llelfdsedp rerdflkttl hriygkflgl
      181 rayirkqinn ifyrfiyete hhngiaelle ilgsiingfa lplkeehkif llkvllplhk
      241 vkslsvyhpq laycvvqfle kdstltepvv mallkywpkt hspkevmfln eleeildvie
      301 psefvkimep lfrqlakcvs sphfqvaera lyywnneyim slisdnaaki lpimfpslyr
      361 nskthwnkti hgliynalkl fmemnqklfd dctqqfkaek lkhrkirrrt vllhaaspsc
      421 lrtptprkpw kltagpmswp prtaaslrga asgpgppvlf ril
//
LOCUS       XP_005267884             449 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
            gamma isoform isoform X11 [Homo sapiens].
ACCESSION   XP_005267884
VERSION     XP_005267884.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267827.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..449
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..449
                     /product="serine/threonine-protein phosphatase 2A 56 kDa
                     regulatory subunit gamma isoform isoform X11"
                     /calculated_mol_wt=52519
     Region          1..362
                     /region_name="B56"
                     /note="Protein phosphatase 2A regulatory B subunit (B56
                     family); pfam01603"
                     /db_xref="CDD:460264"
     CDS             1..449
                     /gene="PPP2R5C"
                     /gene_synonym="B56G; B56gamma; HJS4; PR61G"
                     /coded_by="XM_005267827.2:411..1760"
                     /db_xref="GeneID:5527"
                     /db_xref="HGNC:HGNC:9311"
                     /db_xref="MIM:601645"
ORIGIN      
        1 mveyithnrn vitepiypev vhmfavnmfr tlppssnptg aefdpeedep tleaawphlq
       61 lvyefflrfl espdfqpnia kkyidqkfvl qllelfdsed prerdflktt lhriygkflg
      121 lrayirkqin nifyrfiyet ehhngiaell eilgsiingf alplkeehki fllkvllplh
      181 kvkslsvyhp qlaycvvqfl ekdstltepv vmallkywpk thspkevmfl neleeildvi
      241 epsefvkime plfrqlakcv ssphfqvaer alyywnneyi mslisdnaak ilpimfpsly
      301 rnskthwnkt ihgliynalk lfmemnqklf ddctqqfkae klkeklkmke reeawvkien
      361 lakanpqytv ysqastmsip vametdgplf edvqmlrktv kdeahqaqkd pkkdrplarr
      421 kselpqdpht kkaleahcra delasqdgr
//
LOCUS       XP_047287492             449 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
            gamma isoform isoform X11 [Homo sapiens].
ACCESSION   XP_047287492
VERSION     XP_047287492.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431536.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..449
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..449
                     /product="serine/threonine-protein phosphatase 2A 56 kDa
                     regulatory subunit gamma isoform isoform X11"
                     /calculated_mol_wt=52519
     Region          1..362
                     /region_name="B56"
                     /note="Protein phosphatase 2A regulatory B subunit (B56
                     family); pfam01603"
                     /db_xref="CDD:460264"
     CDS             1..449
                     /gene="PPP2R5C"
                     /gene_synonym="B56G; B56gamma; HJS4; PR61G"
                     /coded_by="XM_047431536.1:3069..4418"
                     /db_xref="GeneID:5527"
                     /db_xref="HGNC:HGNC:9311"
                     /db_xref="MIM:601645"
ORIGIN      
        1 mveyithnrn vitepiypev vhmfavnmfr tlppssnptg aefdpeedep tleaawphlq
       61 lvyefflrfl espdfqpnia kkyidqkfvl qllelfdsed prerdflktt lhriygkflg
      121 lrayirkqin nifyrfiyet ehhngiaell eilgsiingf alplkeehki fllkvllplh
      181 kvkslsvyhp qlaycvvqfl ekdstltepv vmallkywpk thspkevmfl neleeildvi
      241 epsefvkime plfrqlakcv ssphfqvaer alyywnneyi mslisdnaak ilpimfpsly
      301 rnskthwnkt ihgliynalk lfmemnqklf ddctqqfkae klkeklkmke reeawvkien
      361 lakanpqytv ysqastmsip vametdgplf edvqmlrktv kdeahqaqkd pkkdrplarr
      421 kselpqdpht kkaleahcra delasqdgr
//
LOCUS       XP_047287493             449 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
            gamma isoform isoform X11 [Homo sapiens].
ACCESSION   XP_047287493
VERSION     XP_047287493.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431537.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..449
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..449
                     /product="serine/threonine-protein phosphatase 2A 56 kDa
                     regulatory subunit gamma isoform isoform X11"
                     /calculated_mol_wt=52519
     Region          1..362
                     /region_name="B56"
                     /note="Protein phosphatase 2A regulatory B subunit (B56
                     family); pfam01603"
                     /db_xref="CDD:460264"
     CDS             1..449
                     /gene="PPP2R5C"
                     /gene_synonym="B56G; B56gamma; HJS4; PR61G"
                     /coded_by="XM_047431537.1:2795..4144"
                     /db_xref="GeneID:5527"
                     /db_xref="HGNC:HGNC:9311"
                     /db_xref="MIM:601645"
ORIGIN      
        1 mveyithnrn vitepiypev vhmfavnmfr tlppssnptg aefdpeedep tleaawphlq
       61 lvyefflrfl espdfqpnia kkyidqkfvl qllelfdsed prerdflktt lhriygkflg
      121 lrayirkqin nifyrfiyet ehhngiaell eilgsiingf alplkeehki fllkvllplh
      181 kvkslsvyhp qlaycvvqfl ekdstltepv vmallkywpk thspkevmfl neleeildvi
      241 epsefvkime plfrqlakcv ssphfqvaer alyywnneyi mslisdnaak ilpimfpsly
      301 rnskthwnkt ihgliynalk lfmemnqklf ddctqqfkae klkeklkmke reeawvkien
      361 lakanpqytv ysqastmsip vametdgplf edvqmlrktv kdeahqaqkd pkkdrplarr
      421 kselpqdpht kkaleahcra delasqdgr
//
LOCUS       XP_047287494             449 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
            gamma isoform isoform X11 [Homo sapiens].
ACCESSION   XP_047287494
VERSION     XP_047287494.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431538.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..449
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..449
                     /product="serine/threonine-protein phosphatase 2A 56 kDa
                     regulatory subunit gamma isoform isoform X11"
                     /calculated_mol_wt=52519
     Region          1..362
                     /region_name="B56"
                     /note="Protein phosphatase 2A regulatory B subunit (B56
                     family); pfam01603"
                     /db_xref="CDD:460264"
     CDS             1..449
                     /gene="PPP2R5C"
                     /gene_synonym="B56G; B56gamma; HJS4; PR61G"
                     /coded_by="XM_047431538.1:712..2061"
                     /db_xref="GeneID:5527"
                     /db_xref="HGNC:HGNC:9311"
                     /db_xref="MIM:601645"
ORIGIN      
        1 mveyithnrn vitepiypev vhmfavnmfr tlppssnptg aefdpeedep tleaawphlq
       61 lvyefflrfl espdfqpnia kkyidqkfvl qllelfdsed prerdflktt lhriygkflg
      121 lrayirkqin nifyrfiyet ehhngiaell eilgsiingf alplkeehki fllkvllplh
      181 kvkslsvyhp qlaycvvqfl ekdstltepv vmallkywpk thspkevmfl neleeildvi
      241 epsefvkime plfrqlakcv ssphfqvaer alyywnneyi mslisdnaak ilpimfpsly
      301 rnskthwnkt ihgliynalk lfmemnqklf ddctqqfkae klkeklkmke reeawvkien
      361 lakanpqytv ysqastmsip vametdgplf edvqmlrktv kdeahqaqkd pkkdrplarr
      421 kselpqdpht kkaleahcra delasqdgr
//
LOCUS       XP_011535222             449 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
            gamma isoform isoform X11 [Homo sapiens].
ACCESSION   XP_011535222
VERSION     XP_011535222.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536920.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..449
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..449
                     /product="serine/threonine-protein phosphatase 2A 56 kDa
                     regulatory subunit gamma isoform isoform X11"
                     /calculated_mol_wt=52519
     Region          1..362
                     /region_name="B56"
                     /note="Protein phosphatase 2A regulatory B subunit (B56
                     family); pfam01603"
                     /db_xref="CDD:460264"
     CDS             1..449
                     /gene="PPP2R5C"
                     /gene_synonym="B56G; B56gamma; HJS4; PR61G"
                     /coded_by="XM_011536920.2:438..1787"
                     /db_xref="GeneID:5527"
                     /db_xref="HGNC:HGNC:9311"
                     /db_xref="MIM:601645"
ORIGIN      
        1 mveyithnrn vitepiypev vhmfavnmfr tlppssnptg aefdpeedep tleaawphlq
       61 lvyefflrfl espdfqpnia kkyidqkfvl qllelfdsed prerdflktt lhriygkflg
      121 lrayirkqin nifyrfiyet ehhngiaell eilgsiingf alplkeehki fllkvllplh
      181 kvkslsvyhp qlaycvvqfl ekdstltepv vmallkywpk thspkevmfl neleeildvi
      241 epsefvkime plfrqlakcv ssphfqvaer alyywnneyi mslisdnaak ilpimfpsly
      301 rnskthwnkt ihgliynalk lfmemnqklf ddctqqfkae klkeklkmke reeawvkien
      361 lakanpqytv ysqastmsip vametdgplf edvqmlrktv kdeahqaqkd pkkdrplarr
      421 kselpqdpht kkaleahcra delasqdgr
//
LOCUS       XP_047287495             449 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
            gamma isoform isoform X11 [Homo sapiens].
ACCESSION   XP_047287495
VERSION     XP_047287495.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431539.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..449
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..449
                     /product="serine/threonine-protein phosphatase 2A 56 kDa
                     regulatory subunit gamma isoform isoform X11"
                     /calculated_mol_wt=52519
     Region          1..362
                     /region_name="B56"
                     /note="Protein phosphatase 2A regulatory B subunit (B56
                     family); pfam01603"
                     /db_xref="CDD:460264"
     CDS             1..449
                     /gene="PPP2R5C"
                     /gene_synonym="B56G; B56gamma; HJS4; PR61G"
                     /coded_by="XM_047431539.1:733..2082"
                     /db_xref="GeneID:5527"
                     /db_xref="HGNC:HGNC:9311"
                     /db_xref="MIM:601645"
ORIGIN      
        1 mveyithnrn vitepiypev vhmfavnmfr tlppssnptg aefdpeedep tleaawphlq
       61 lvyefflrfl espdfqpnia kkyidqkfvl qllelfdsed prerdflktt lhriygkflg
      121 lrayirkqin nifyrfiyet ehhngiaell eilgsiingf alplkeehki fllkvllplh
      181 kvkslsvyhp qlaycvvqfl ekdstltepv vmallkywpk thspkevmfl neleeildvi
      241 epsefvkime plfrqlakcv ssphfqvaer alyywnneyi mslisdnaak ilpimfpsly
      301 rnskthwnkt ihgliynalk lfmemnqklf ddctqqfkae klkeklkmke reeawvkien
      361 lakanpqytv ysqastmsip vametdgplf edvqmlrktv kdeahqaqkd pkkdrplarr
      421 kselpqdpht kkaleahcra delasqdgr
//
LOCUS       XP_047287496             410 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
            gamma isoform isoform X12 [Homo sapiens].
ACCESSION   XP_047287496
VERSION     XP_047287496.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431540.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 1% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..410
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..410
                     /product="serine/threonine-protein phosphatase 2A 56 kDa
                     regulatory subunit gamma isoform isoform X12"
                     /calculated_mol_wt=48119
     Region          1..362
                     /region_name="B56"
                     /note="Protein phosphatase 2A regulatory B subunit (B56
                     family); pfam01603"
                     /db_xref="CDD:460264"
     CDS             1..410
                     /gene="PPP2R5C"
                     /gene_synonym="B56G; B56gamma; HJS4; PR61G"
                     /coded_by="XM_047431540.1:198..1430"
                     /db_xref="GeneID:5527"
                     /db_xref="HGNC:HGNC:9311"
                     /db_xref="MIM:601645"
ORIGIN      
        1 mveyithnrn vitepiypev vhmfavnmfr tlppssnptg aefdpeedep tleaawphlq
       61 lvyefflrfl espdfqpnia kkyidqkfvl qllelfdsed prerdflktt lhriygkflg
      121 lrayirkqin nifyrfiyet ehhngiaell eilgsiingf alplkeehki fllkvllplh
      181 kvkslsvyhp qlaycvvqfl ekdstltepv vmallkywpk thspkevmfl neleeildvi
      241 epsefvkime plfrqlakcv ssphfqvaer alyywnneyi mslisdnaak ilpimfpsly
      301 rnskthwnkt ihgliynalk lfmemnqklf ddctqqfkae klkeklkmke reeawvkien
      361 lakanpqaqk dpkkdrplar rkselpqdph tkkaleahcr adelasqdgr
//
LOCUS       XP_047287497             449 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
            gamma isoform isoform X11 [Homo sapiens].
ACCESSION   XP_047287497
VERSION     XP_047287497.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431541.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..449
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..449
                     /product="serine/threonine-protein phosphatase 2A 56 kDa
                     regulatory subunit gamma isoform isoform X11"
                     /calculated_mol_wt=52519
     Region          1..362
                     /region_name="B56"
                     /note="Protein phosphatase 2A regulatory B subunit (B56
                     family); pfam01603"
                     /db_xref="CDD:460264"
     CDS             1..449
                     /gene="PPP2R5C"
                     /gene_synonym="B56G; B56gamma; HJS4; PR61G"
                     /coded_by="XM_047431541.1:245..1594"
                     /db_xref="GeneID:5527"
                     /db_xref="HGNC:HGNC:9311"
                     /db_xref="MIM:601645"
ORIGIN      
        1 mveyithnrn vitepiypev vhmfavnmfr tlppssnptg aefdpeedep tleaawphlq
       61 lvyefflrfl espdfqpnia kkyidqkfvl qllelfdsed prerdflktt lhriygkflg
      121 lrayirkqin nifyrfiyet ehhngiaell eilgsiingf alplkeehki fllkvllplh
      181 kvkslsvyhp qlaycvvqfl ekdstltepv vmallkywpk thspkevmfl neleeildvi
      241 epsefvkime plfrqlakcv ssphfqvaer alyywnneyi mslisdnaak ilpimfpsly
      301 rnskthwnkt ihgliynalk lfmemnqklf ddctqqfkae klkeklkmke reeawvkien
      361 lakanpqytv ysqastmsip vametdgplf edvqmlrktv kdeahqaqkd pkkdrplarr
      421 kselpqdpht kkaleahcra delasqdgr
//
LOCUS       XP_024305415             467 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
            epsilon isoform isoform X1 [Homo sapiens].
ACCESSION   XP_024305415
VERSION     XP_024305415.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449647.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..467
                     /product="serine/threonine-protein phosphatase 2A 56 kDa
                     regulatory subunit epsilon isoform isoform X1"
                     /calculated_mol_wt=54568
     Region          2..>67
                     /region_name="B56"
                     /note="Protein phosphatase 2A regulatory B subunit (B56
                     family); cl27532"
                     /db_xref="CDD:474937"
     Region          55..435
                     /region_name="B56"
                     /note="Protein phosphatase 2A regulatory B subunit (B56
                     family); pfam01603"
                     /db_xref="CDD:460264"
     CDS             1..467
                     /gene="PPP2R5E"
                     /gene_synonym="B56E; B56epsilon"
                     /coded_by="XM_024449647.2:9..1412"
                     /db_xref="GeneID:5529"
                     /db_xref="HGNC:HGNC:9313"
                     /db_xref="MIM:601647"
ORIGIN      
        1 mssapttpps vdkvdgfsrk svrkarqkrs qsssqfrsqg kpieltplpl lkdvpsseqp
       61 elflkklqqc cvifdfmdtl sdlkmkeykr stlnelvdyi tisrgclteq typevvrmvs
      121 cnifrtlpps dsnefdpeed eptleaswph lqlvyeffir flesqefqps iakkyidqkf
      181 vlqllelfds edprerdylk tvlhriygkf lglrafirkq inniflrfvy etehfngvae
      241 lleilgsiin gfalplkaeh kqflvkvlip lhtvrslslf haqlaycivq flekdpslte
      301 pvirglmkfw pktcsqkevm flgeleeild viepsqfvki qeplfkqiak cvssphfqva
      361 eralyywnne yimslieens nvilpimfss lyriskehwn paivalvynv lkafmemnst
      421 mfdeltatyk sdrqrekkke kereelwkkl edlelkrglr rdgiipt
//
LOCUS       XP_047287499             462 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
            epsilon isoform isoform X2 [Homo sapiens].
ACCESSION   XP_047287499
VERSION     XP_047287499.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431543.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..462
                     /product="serine/threonine-protein phosphatase 2A 56 kDa
                     regulatory subunit epsilon isoform isoform X2"
                     /calculated_mol_wt=53912
     Region          2..>67
                     /region_name="B56"
                     /note="Protein phosphatase 2A regulatory B subunit (B56
                     family); cl27532"
                     /db_xref="CDD:474937"
     Region          55..430
                     /region_name="B56"
                     /note="Protein phosphatase 2A regulatory B subunit (B56
                     family); pfam01603"
                     /db_xref="CDD:460264"
     CDS             1..462
                     /gene="PPP2R5E"
                     /gene_synonym="B56E; B56epsilon"
                     /coded_by="XM_047431543.1:604..1992"
                     /db_xref="GeneID:5529"
                     /db_xref="HGNC:HGNC:9313"
                     /db_xref="MIM:601647"
ORIGIN      
        1 mssapttpps vdkvdgfsrk svrkarqkrs qsssqfrsqg kpieltplpl lkdvpsseqp
       61 elflkklqqc cvifdfmdtl sdlkmkeykr stlnelvdyi tisrgclteq typevvrmvs
      121 cnifrtlpps dsnefdpeed eptleaswph lqlvyeffir flesqefqps iakkyidqkf
      181 vlqllelfds edprerdylk tvlhriygkf lglrafirkq inniflrfvy etehfngvae
      241 lleilgsiin gfalplkaeh kqflvkvlip lhtvrslslf haqlaycivq flekdpslte
      301 pvirglmkfw pktcsqkevm flgeleeild viepsqfvki qeplfkqiak cvssphfqva
      361 eralyywnne yimslieens nvilpimfss lyriskehwn paivalvynv lkafmemnst
      421 mfdeltatyn ekkkekeree lwkkledlel krglrrdgii pt
//
LOCUS       XP_047287500             391 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
            epsilon isoform isoform X3 [Homo sapiens].
ACCESSION   XP_047287500
VERSION     XP_047287500.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431544.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..391
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..391
                     /product="serine/threonine-protein phosphatase 2A 56 kDa
                     regulatory subunit epsilon isoform isoform X3"
                     /calculated_mol_wt=46049
     Region          2..359
                     /region_name="B56"
                     /note="Protein phosphatase 2A regulatory B subunit (B56
                     family); pfam01603"
                     /db_xref="CDD:460264"
     CDS             1..391
                     /gene="PPP2R5E"
                     /gene_synonym="B56E; B56epsilon"
                     /coded_by="XM_047431544.1:103..1278"
                     /db_xref="GeneID:5529"
                     /db_xref="HGNC:HGNC:9313"
                     /db_xref="MIM:601647"
ORIGIN      
        1 mdtlsdlkmk eykrstlnel vdyitisrgc lteqtypevv rmvscnifrt lppsdsnefd
       61 peedeptlea swphlqlvye ffirflesqe fqpsiakkyi dqkfvlqlle lfdsedprer
      121 dylktvlhri ygkflglraf irkqinnifl rfvyetehfn gvaelleilg siingfalpl
      181 kaehkqflvk vliplhtvrs lslfhaqlay civqflekdp sltepvirgl mkfwpktcsq
      241 kevmflgele eildviepsq fvkiqeplfk qiakcvssph fqvaeralyy wnneyimsli
      301 eensnvilpi mfsslyrisk ehwnpaival vynvlkafme mnstmfdelt atyksdrqre
      361 kkkekereel wkkledlelk rglrrdgiip t
//
LOCUS       XP_005267890            1132 aa            linear   PRI 05-AUG-2025
DEFINITION  mis18-binding protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_005267890
VERSION     XP_005267890.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267833.6
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1132
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1132
                     /product="mis18-binding protein 1 isoform X1"
                     /calculated_mol_wt=128955
     Region          383..470
                     /region_name="SANTA"
                     /note="SANTA (SANT Associated); pfam09133"
                     /db_xref="CDD:462689"
     Region          879..925
                     /region_name="SANT"
                     /note="'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains.
                     Tandem copies of the domain bind telomeric DNA tandem
                     repeatsas part of the capping complex. Binding is sequence
                     dependent for repeats which contain the G/C rich motif
                     [C2-3 A (CA)1-6]. The domain is...; cd00167"
                     /db_xref="CDD:238096"
     Site            order(880,913..914,916..917,919..921,923..925)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238096"
     CDS             1..1132
                     /gene="MIS18BP1"
                     /gene_synonym="C14orf106; HSA242977; KNL2; M18BP1"
                     /coded_by="XM_005267833.6:368..3766"
                     /db_xref="GeneID:55320"
                     /db_xref="HGNC:HGNC:20190"
                     /db_xref="MIM:618139"
ORIGIN      
        1 miatplkhsr iylppeassq rrnlpmdaif fdsipsgtlt pvkdlvkyqn sslklndhkk
       61 nqflkmttfn nknifqstml teattsnssl disaikpnkd glknkanyes pgkiflrmke
      121 kvlrdkqeqp srnssllepq ksgnnetftp nrvekkklqh tylceekenn ksfqsddssl
      181 rasvqgvple ssnndiflpv kqkiqcqqek kaplhnltye lptlnqeqen flavearnkt
      241 ltraqlakqi fhskesivat tkskkdtfvl esvdsadeqf qntnaetlst ncipikngsl
      301 lmvsdsertt egtsqqkvke gngktvpget glpgsmkdtc kivlatprlh itiprrskrn
      361 isklspprif qtvtnglkkn qvvqlqewmi ksinnntaic vegklidvtn iywhsnviie
      421 riehnklrti sgnvyilkgm idqismkeag ypnylirkfm fgfpenwkeh idnfleqlra
      481 geknrektkq kqktgrsvrd irksmkndar enqtdtaqra tttydfdcdn lelksnkhse
      541 spgatelnmc hsncqnkptl rfpddqvnnt iqngggddls nqeligkkey kmsskklkig
      601 ertneriiks qkqetteeld vsidiltsre qffsdeerky mainqkkayi lvtplksrkv
      661 ieqrcmrynl sagtikavtd fvipecqkks pisksmgtle ntfeghkskn kedcderdll
      721 tvnrkikisn lekeqmltsd fkkntrllpk lkkienqvam sfykhqsspd lsseesetek
      781 eikrkaevkk tkagntkeav vhlrkstrnt snipvilepe teesenefyi kqkkarpsvk
      841 etlqksgvrk efpiteavgs dktnrhplec lpgliqdkew nekelqklhc afaslpkhkp
      901 gfwsevaaav gsrspeecqr kymenprgkg sqkhvtkkkp anskgqngkr gdadqkqtik
      961 itakvgtlkr kqqmrefleq lpkddhddff sttplqhqri llpsfqdsed dddilpnmdk
     1021 npttpssvif plvktpqcqh vspgmlgsin rndcdkyvfr mqkyhksngg ivwgnikkkl
     1081 vetdfstptp rrktpfntdl gensgigklf tnavesldee ekdyyfsnsd sa
//
LOCUS       XP_016876914            1132 aa            linear   PRI 05-AUG-2025
DEFINITION  mis18-binding protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_016876914
VERSION     XP_016876914.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021425.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1132
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1132
                     /product="mis18-binding protein 1 isoform X1"
                     /calculated_mol_wt=128955
     Region          383..470
                     /region_name="SANTA"
                     /note="SANTA (SANT Associated); pfam09133"
                     /db_xref="CDD:462689"
     Region          879..925
                     /region_name="SANT"
                     /note="'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains.
                     Tandem copies of the domain bind telomeric DNA tandem
                     repeatsas part of the capping complex. Binding is sequence
                     dependent for repeats which contain the G/C rich motif
                     [C2-3 A (CA)1-6]. The domain is...; cd00167"
                     /db_xref="CDD:238096"
     Site            order(880,913..914,916..917,919..921,923..925)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238096"
     CDS             1..1132
                     /gene="MIS18BP1"
                     /gene_synonym="C14orf106; HSA242977; KNL2; M18BP1"
                     /coded_by="XM_017021425.2:474..3872"
                     /db_xref="GeneID:55320"
                     /db_xref="HGNC:HGNC:20190"
                     /db_xref="MIM:618139"
ORIGIN      
        1 miatplkhsr iylppeassq rrnlpmdaif fdsipsgtlt pvkdlvkyqn sslklndhkk
       61 nqflkmttfn nknifqstml teattsnssl disaikpnkd glknkanyes pgkiflrmke
      121 kvlrdkqeqp srnssllepq ksgnnetftp nrvekkklqh tylceekenn ksfqsddssl
      181 rasvqgvple ssnndiflpv kqkiqcqqek kaplhnltye lptlnqeqen flavearnkt
      241 ltraqlakqi fhskesivat tkskkdtfvl esvdsadeqf qntnaetlst ncipikngsl
      301 lmvsdsertt egtsqqkvke gngktvpget glpgsmkdtc kivlatprlh itiprrskrn
      361 isklspprif qtvtnglkkn qvvqlqewmi ksinnntaic vegklidvtn iywhsnviie
      421 riehnklrti sgnvyilkgm idqismkeag ypnylirkfm fgfpenwkeh idnfleqlra
      481 geknrektkq kqktgrsvrd irksmkndar enqtdtaqra tttydfdcdn lelksnkhse
      541 spgatelnmc hsncqnkptl rfpddqvnnt iqngggddls nqeligkkey kmsskklkig
      601 ertneriiks qkqetteeld vsidiltsre qffsdeerky mainqkkayi lvtplksrkv
      661 ieqrcmrynl sagtikavtd fvipecqkks pisksmgtle ntfeghkskn kedcderdll
      721 tvnrkikisn lekeqmltsd fkkntrllpk lkkienqvam sfykhqsspd lsseesetek
      781 eikrkaevkk tkagntkeav vhlrkstrnt snipvilepe teesenefyi kqkkarpsvk
      841 etlqksgvrk efpiteavgs dktnrhplec lpgliqdkew nekelqklhc afaslpkhkp
      901 gfwsevaaav gsrspeecqr kymenprgkg sqkhvtkkkp anskgqngkr gdadqkqtik
      961 itakvgtlkr kqqmrefleq lpkddhddff sttplqhqri llpsfqdsed dddilpnmdk
     1021 npttpssvif plvktpqcqh vspgmlgsin rndcdkyvfr mqkyhksngg ivwgnikkkl
     1081 vetdfstptp rrktpfntdl gensgigklf tnavesldee ekdyyfsnsd sa
//
LOCUS       XP_047287501            1132 aa            linear   PRI 05-AUG-2025
DEFINITION  mis18-binding protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047287501
VERSION     XP_047287501.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431545.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1132
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1132
                     /product="mis18-binding protein 1 isoform X1"
                     /calculated_mol_wt=128955
     Region          383..470
                     /region_name="SANTA"
                     /note="SANTA (SANT Associated); pfam09133"
                     /db_xref="CDD:462689"
     Region          879..925
                     /region_name="SANT"
                     /note="'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains.
                     Tandem copies of the domain bind telomeric DNA tandem
                     repeatsas part of the capping complex. Binding is sequence
                     dependent for repeats which contain the G/C rich motif
                     [C2-3 A (CA)1-6]. The domain is...; cd00167"
                     /db_xref="CDD:238096"
     Site            order(880,913..914,916..917,919..921,923..925)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238096"
     CDS             1..1132
                     /gene="MIS18BP1"
                     /gene_synonym="C14orf106; HSA242977; KNL2; M18BP1"
                     /coded_by="XM_047431545.1:717..4115"
                     /db_xref="GeneID:55320"
                     /db_xref="HGNC:HGNC:20190"
                     /db_xref="MIM:618139"
ORIGIN      
        1 miatplkhsr iylppeassq rrnlpmdaif fdsipsgtlt pvkdlvkyqn sslklndhkk
       61 nqflkmttfn nknifqstml teattsnssl disaikpnkd glknkanyes pgkiflrmke
      121 kvlrdkqeqp srnssllepq ksgnnetftp nrvekkklqh tylceekenn ksfqsddssl
      181 rasvqgvple ssnndiflpv kqkiqcqqek kaplhnltye lptlnqeqen flavearnkt
      241 ltraqlakqi fhskesivat tkskkdtfvl esvdsadeqf qntnaetlst ncipikngsl
      301 lmvsdsertt egtsqqkvke gngktvpget glpgsmkdtc kivlatprlh itiprrskrn
      361 isklspprif qtvtnglkkn qvvqlqewmi ksinnntaic vegklidvtn iywhsnviie
      421 riehnklrti sgnvyilkgm idqismkeag ypnylirkfm fgfpenwkeh idnfleqlra
      481 geknrektkq kqktgrsvrd irksmkndar enqtdtaqra tttydfdcdn lelksnkhse
      541 spgatelnmc hsncqnkptl rfpddqvnnt iqngggddls nqeligkkey kmsskklkig
      601 ertneriiks qkqetteeld vsidiltsre qffsdeerky mainqkkayi lvtplksrkv
      661 ieqrcmrynl sagtikavtd fvipecqkks pisksmgtle ntfeghkskn kedcderdll
      721 tvnrkikisn lekeqmltsd fkkntrllpk lkkienqvam sfykhqsspd lsseesetek
      781 eikrkaevkk tkagntkeav vhlrkstrnt snipvilepe teesenefyi kqkkarpsvk
      841 etlqksgvrk efpiteavgs dktnrhplec lpgliqdkew nekelqklhc afaslpkhkp
      901 gfwsevaaav gsrspeecqr kymenprgkg sqkhvtkkkp anskgqngkr gdadqkqtik
      961 itakvgtlkr kqqmrefleq lpkddhddff sttplqhqri llpsfqdsed dddilpnmdk
     1021 npttpssvif plvktpqcqh vspgmlgsin rndcdkyvfr mqkyhksngg ivwgnikkkl
     1081 vetdfstptp rrktpfntdl gensgigklf tnavesldee ekdyyfsnsd sa
//
LOCUS       XP_047287502            1132 aa            linear   PRI 05-AUG-2025
DEFINITION  mis18-binding protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047287502
VERSION     XP_047287502.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431546.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1132
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1132
                     /product="mis18-binding protein 1 isoform X1"
                     /calculated_mol_wt=128955
     Region          383..470
                     /region_name="SANTA"
                     /note="SANTA (SANT Associated); pfam09133"
                     /db_xref="CDD:462689"
     Region          879..925
                     /region_name="SANT"
                     /note="'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains.
                     Tandem copies of the domain bind telomeric DNA tandem
                     repeatsas part of the capping complex. Binding is sequence
                     dependent for repeats which contain the G/C rich motif
                     [C2-3 A (CA)1-6]. The domain is...; cd00167"
                     /db_xref="CDD:238096"
     Site            order(880,913..914,916..917,919..921,923..925)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238096"
     CDS             1..1132
                     /gene="MIS18BP1"
                     /gene_synonym="C14orf106; HSA242977; KNL2; M18BP1"
                     /coded_by="XM_047431546.1:381..3779"
                     /db_xref="GeneID:55320"
                     /db_xref="HGNC:HGNC:20190"
                     /db_xref="MIM:618139"
ORIGIN      
        1 miatplkhsr iylppeassq rrnlpmdaif fdsipsgtlt pvkdlvkyqn sslklndhkk
       61 nqflkmttfn nknifqstml teattsnssl disaikpnkd glknkanyes pgkiflrmke
      121 kvlrdkqeqp srnssllepq ksgnnetftp nrvekkklqh tylceekenn ksfqsddssl
      181 rasvqgvple ssnndiflpv kqkiqcqqek kaplhnltye lptlnqeqen flavearnkt
      241 ltraqlakqi fhskesivat tkskkdtfvl esvdsadeqf qntnaetlst ncipikngsl
      301 lmvsdsertt egtsqqkvke gngktvpget glpgsmkdtc kivlatprlh itiprrskrn
      361 isklspprif qtvtnglkkn qvvqlqewmi ksinnntaic vegklidvtn iywhsnviie
      421 riehnklrti sgnvyilkgm idqismkeag ypnylirkfm fgfpenwkeh idnfleqlra
      481 geknrektkq kqktgrsvrd irksmkndar enqtdtaqra tttydfdcdn lelksnkhse
      541 spgatelnmc hsncqnkptl rfpddqvnnt iqngggddls nqeligkkey kmsskklkig
      601 ertneriiks qkqetteeld vsidiltsre qffsdeerky mainqkkayi lvtplksrkv
      661 ieqrcmrynl sagtikavtd fvipecqkks pisksmgtle ntfeghkskn kedcderdll
      721 tvnrkikisn lekeqmltsd fkkntrllpk lkkienqvam sfykhqsspd lsseesetek
      781 eikrkaevkk tkagntkeav vhlrkstrnt snipvilepe teesenefyi kqkkarpsvk
      841 etlqksgvrk efpiteavgs dktnrhplec lpgliqdkew nekelqklhc afaslpkhkp
      901 gfwsevaaav gsrspeecqr kymenprgkg sqkhvtkkkp anskgqngkr gdadqkqtik
      961 itakvgtlkr kqqmrefleq lpkddhddff sttplqhqri llpsfqdsed dddilpnmdk
     1021 npttpssvif plvktpqcqh vspgmlgsin rndcdkyvfr mqkyhksngg ivwgnikkkl
     1081 vetdfstptp rrktpfntdl gensgigklf tnavesldee ekdyyfsnsd sa
//
LOCUS       XP_047287503             898 aa            linear   PRI 05-AUG-2025
DEFINITION  mis18-binding protein 1 isoform X2 [Homo sapiens].
ACCESSION   XP_047287503
VERSION     XP_047287503.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431547.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..898
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..898
                     /product="mis18-binding protein 1 isoform X2"
                     /calculated_mol_wt=102521
     Region          383..470
                     /region_name="SANTA"
                     /note="SANTA (SANT Associated); pfam09133"
                     /db_xref="CDD:462689"
     CDS             1..898
                     /gene="MIS18BP1"
                     /gene_synonym="C14orf106; HSA242977; KNL2; M18BP1"
                     /coded_by="XM_047431547.1:260..2956"
                     /db_xref="GeneID:55320"
                     /db_xref="HGNC:HGNC:20190"
                     /db_xref="MIM:618139"
ORIGIN      
        1 miatplkhsr iylppeassq rrnlpmdaif fdsipsgtlt pvkdlvkyqn sslklndhkk
       61 nqflkmttfn nknifqstml teattsnssl disaikpnkd glknkanyes pgkiflrmke
      121 kvlrdkqeqp srnssllepq ksgnnetftp nrvekkklqh tylceekenn ksfqsddssl
      181 rasvqgvple ssnndiflpv kqkiqcqqek kaplhnltye lptlnqeqen flavearnkt
      241 ltraqlakqi fhskesivat tkskkdtfvl esvdsadeqf qntnaetlst ncipikngsl
      301 lmvsdsertt egtsqqkvke gngktvpget glpgsmkdtc kivlatprlh itiprrskrn
      361 isklspprif qtvtnglkkn qvvqlqewmi ksinnntaic vegklidvtn iywhsnviie
      421 riehnklrti sgnvyilkgm idqismkeag ypnylirkfm fgfpenwkeh idnfleqlra
      481 geknrektkq kqktgrsvrd irksmkndar enqtdtaqra tttydfdcdn lelksnkhse
      541 spgatelnmc hsncqnkptl rfpddqvnnt iqngggddls nqeligkkey kmsskklkig
      601 ertneriiks qkqetteeld vsidiltsre qffsdeerky mainqkkayi lvtplksrkv
      661 ieqrcmrynl sagtikavtd fvipecqkks pisksmgtle ntfeghkskn kedcderdll
      721 tvnrkikisn lekeqmltsd fkkntrllpk lkkienqvam sfykhqsspd lsseesetek
      781 eikrkaevkk tkagntkeav vhlrkstrnt snipvilepe teesenefyi kqkkarpsvk
      841 etlqksgvrk efpiteavgs dktnrhplec lpgliqdkew nekelqklhc tnlvsgqr
//
LOCUS       XP_011535225             744 aa            linear   PRI 05-AUG-2025
DEFINITION  mis18-binding protein 1 isoform X3 [Homo sapiens].
ACCESSION   XP_011535225
VERSION     XP_011535225.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536923.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..744
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..744
                     /product="mis18-binding protein 1 isoform X3"
                     /calculated_mol_wt=85223
     Region          11..82
                     /region_name="SANTA"
                     /note="SANTA (SANT Associated); pfam09133"
                     /db_xref="CDD:462689"
     Region          491..537
                     /region_name="SANT"
                     /note="'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains.
                     Tandem copies of the domain bind telomeric DNA tandem
                     repeatsas part of the capping complex. Binding is sequence
                     dependent for repeats which contain the G/C rich motif
                     [C2-3 A (CA)1-6]. The domain is...; cd00167"
                     /db_xref="CDD:238096"
     Site            order(492,525..526,528..529,531..533,535..537)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238096"
     CDS             1..744
                     /gene="MIS18BP1"
                     /gene_synonym="C14orf106; HSA242977; KNL2; M18BP1"
                     /coded_by="XM_011536923.1:109..2343"
                     /db_xref="GeneID:55320"
                     /db_xref="HGNC:HGNC:20190"
                     /db_xref="MIM:618139"
ORIGIN      
        1 miksinnnta icvegklidv tniywhsnvi ieriehnklr tisgnvyilk gmidqismke
       61 agypnylirk fmfgfpenwk ehidnfleql rageknrekt kqkqktgrsv rdirksmknd
      121 arenqtdtaq ratttydfdc dnlelksnkh sespgateln mchsncqnkp tlrfpddqvn
      181 ntiqngggdd lsnqeligkk eykmsskklk igertnerii ksqkqettee ldvsidilts
      241 reqffsdeer kymainqkka yilvtplksr kvieqrcmry nlsagtikav tdfvipecqk
      301 kspisksmgt lentfeghks knkedcderd lltvnrkiki snlekeqmlt sdfkkntrll
      361 pklkkienqv amsfykhqss pdlsseeset ekeikrkaev kktkagntke avvhlrkstr
      421 ntsnipvile peteesenef yikqkkarps vketlqksgv rkefpiteav gsdktnrhpl
      481 eclpgliqdk ewnekelqkl hcafaslpkh kpgfwsevaa avgsrspeec qrkymenprg
      541 kgsqkhvtkk kpanskgqng krgdadqkqt ikitakvgtl krkqqmrefl eqlpkddhdd
      601 ffsttplqhq rillpsfqds eddddilpnm dknpttpssv ifplvktpqc qhvspgmlgs
      661 inrndcdkyv frmqkyhksn ggivwgnikk klvetdfstp tprrktpfnt dlgensgigk
      721 lftnavesld eeekdyyfsn sdsa
//
LOCUS       XP_047287504             629 aa            linear   PRI 05-AUG-2025
DEFINITION  mis18-binding protein 1 isoform X4 [Homo sapiens].
ACCESSION   XP_047287504
VERSION     XP_047287504.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431548.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..629
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..629
                     /product="mis18-binding protein 1 isoform X4"
                     /calculated_mol_wt=71440
     Region          383..470
                     /region_name="SANTA"
                     /note="SANTA (SANT Associated); pfam09133"
                     /db_xref="CDD:462689"
     CDS             1..629
                     /gene="MIS18BP1"
                     /gene_synonym="C14orf106; HSA242977; KNL2; M18BP1"
                     /coded_by="XM_047431548.1:260..2149"
                     /db_xref="GeneID:55320"
                     /db_xref="HGNC:HGNC:20190"
                     /db_xref="MIM:618139"
ORIGIN      
        1 miatplkhsr iylppeassq rrnlpmdaif fdsipsgtlt pvkdlvkyqn sslklndhkk
       61 nqflkmttfn nknifqstml teattsnssl disaikpnkd glknkanyes pgkiflrmke
      121 kvlrdkqeqp srnssllepq ksgnnetftp nrvekkklqh tylceekenn ksfqsddssl
      181 rasvqgvple ssnndiflpv kqkiqcqqek kaplhnltye lptlnqeqen flavearnkt
      241 ltraqlakqi fhskesivat tkskkdtfvl esvdsadeqf qntnaetlst ncipikngsl
      301 lmvsdsertt egtsqqkvke gngktvpget glpgsmkdtc kivlatprlh itiprrskrn
      361 isklspprif qtvtnglkkn qvvqlqewmi ksinnntaic vegklidvtn iywhsnviie
      421 riehnklrti sgnvyilkgm idqismkeag ypnylirkfm fgfpenwkeh idnfleqlra
      481 geknrektkq kqktgrsvrd irksmkndar enqtdtaqra tttydfdcdn lelksnkhse
      541 spgatelnmc hsncqnkptl rfpddqvnnt iqngggddls nqeligkkey kmsskklkig
      601 ertneriiks qkqvllhlfq stnlvsgqr
//
LOCUS       XP_024305416             189 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc transporter ZIP9 isoform X1 [Homo sapiens].
ACCESSION   XP_024305416
VERSION     XP_024305416.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449648.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..189
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..189
                     /product="zinc transporter ZIP9 isoform X1"
                     /calculated_mol_wt=19459
     Region          <13..183
                     /region_name="Zip"
                     /note="ZIP Zinc transporter; cl00437"
                     /db_xref="CDD:444905"
     CDS             1..189
                     /gene="SLC39A9"
                     /gene_synonym="ZIP-9; ZIP9"
                     /coded_by="XM_024449648.2:326..895"
                     /db_xref="GeneID:55334"
                     /db_xref="HGNC:HGNC:20182"
                     /db_xref="MIM:619116"
ORIGIN      
        1 mllvdqigns hvhstddpea arssnskitt tlglvvhaaa dgvalgaaas tsqtsvqliv
       61 fvaimlhkap aafglvsflm haglernrir khllvfalaa pvmsmvtylg lsksskeals
      121 evnatgvaml fsagtflyva tvhvlpevgg ighshkpdat ggrglsrlev aalvlgclip
      181 lilsvghqh
//
LOCUS       XP_047287506             166 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc transporter ZIP9 isoform X2 [Homo sapiens].
ACCESSION   XP_047287506
VERSION     XP_047287506.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431550.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..166
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..166
                     /product="zinc transporter ZIP9 isoform X2"
                     /calculated_mol_wt=17138
     Region          <18..160
                     /region_name="Zip"
                     /note="ZIP Zinc transporter; cl00437"
                     /db_xref="CDD:444905"
     CDS             1..166
                     /gene="SLC39A9"
                     /gene_synonym="ZIP-9; ZIP9"
                     /coded_by="XM_047431550.1:326..826"
                     /db_xref="GeneID:55334"
                     /db_xref="HGNC:HGNC:20182"
                     /db_xref="MIM:619116"
ORIGIN      
        1 mllvdqigns hvhstdadgv algaaastsq tsvqlivfva imlhkapaaf glvsflmhag
       61 lernrirkhl lvfalaapvm smvtylglsk sskealsevn atgvamlfsa gtflyvatvh
      121 vlpevggigh shkpdatggr glsrlevaal vlgcliplil svghqh
//
LOCUS       XP_011535227             706 aa            linear   PRI 05-AUG-2025
DEFINITION  G2/M phase-specific E3 ubiquitin-protein ligase isoform X1 [Homo
            sapiens].
ACCESSION   XP_011535227
VERSION     XP_011535227.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536925.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..706
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..706
                     /product="G2/M phase-specific E3 ubiquitin-protein ligase
                     isoform X1"
                     /calculated_mol_wt=80374
     Region          14..127
                     /region_name="ePHD_PHF7_G2E3_like"
                     /note="Extended PHD finger found in PHD finger protein 7
                     (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase
                     (G2E3); cd15669"
                     /db_xref="CDD:277139"
     Site            order(80,89..93,99,122)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277139"
     Region          232..285
                     /region_name="PHD_PHF7_G2E3_like"
                     /note="PHD finger found in PHD finger protein 7 (PHF7) and
                     G2/M phase-specific E3 ubiquitin-protein ligase (G2E3);
                     cd15496"
                     /db_xref="CDD:276971"
     Site            order(232,254..258,262,280)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:276971"
     Site            order(368,397,411,464,635,660..661,664..668,688)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Region          411..692
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cl27008"
                     /db_xref="CDD:474882"
     Site            order(506,509..510,512..513,518,525,527,531..532,534,540)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..706
                     /gene="G2E3"
                     /gene_synonym="KIAA1333; PHF7B"
                     /coded_by="XM_011536925.3:91..2211"
                     /db_xref="GeneID:55632"
                     /db_xref="HGNC:HGNC:20338"
                     /db_xref="MIM:611299"
ORIGIN      
        1 mneskpgdsq nlacvfcrkh ddcpnkygek ktkekwnltv hyycllmssg iwqrgkeeeg
       61 vygfliedir kevnrasklk ccvckkngas igcvaprckr syhfpcglqr ecifqftgnf
      121 asfcwdhrpv qiitsnnyre slpcticlef iepipsynil rspccknawf hrdclqvqai
      181 nagvfffrct icnnsdifqk emlrmgihip ekdaswelee nayqellqhy ercdvrrcrc
      241 kegrdynapd skweikrcqc cgssgthlac sslrsweqnw eclecrgiiy nsgefqkakk
      301 hvlpnsnnvg itdclleess pklprqspgs qskdllrqgs kfrrnvstll ielgfqikkk
      361 tkrlyinkan iwnsaldafr nrnfnpsyai evayviendn fgsehpgskq eflsllmqhl
      421 ensslfegsl sknlslnsqa lkenlyyeag kmlaislvhg gpspgffskt lfnclvygpe
      481 ntqpilddvs dfdvaqiiir intattvadl ksiinecyny leligclrli ttlsdkymlv
      541 kdilgyhviq rvhtpfesfk qglktlgvle kiqaypeafc silchkpesl sakilselft
      601 vhtlpdvkal gfwnsylqav edgkstttme dilifatgcs sippagfkpt psieclhvdf
      661 pvgnkcnncl aipitntyke fqenmdftir ntlrlekees shyigh
//
LOCUS       XP_011535228             667 aa            linear   PRI 05-AUG-2025
DEFINITION  G2/M phase-specific E3 ubiquitin-protein ligase isoform X2 [Homo
            sapiens].
ACCESSION   XP_011535228
VERSION     XP_011535228.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536926.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..667
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..667
                     /product="G2/M phase-specific E3 ubiquitin-protein ligase
                     isoform X2"
                     /calculated_mol_wt=75628
     Region          14..127
                     /region_name="ePHD_PHF7_G2E3_like"
                     /note="Extended PHD finger found in PHD finger protein 7
                     (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase
                     (G2E3); cd15669"
                     /db_xref="CDD:277139"
     Site            order(80,89..93,99,122)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277139"
     Region          <210..246
                     /region_name="PHD_SF"
                     /note="PHD finger superfamily; cl22851"
                     /db_xref="CDD:473978"
     Site            order(216..219,223,241)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:276966"
     Site            order(329,358,372,425,596,621..622,625..629,649)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Region          372..653
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cl27008"
                     /db_xref="CDD:474882"
     Site            order(467,470..471,473..474,479,486,488,492..493,495,501)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..667
                     /gene="G2E3"
                     /gene_synonym="KIAA1333; PHF7B"
                     /coded_by="XM_011536926.3:120..2123"
                     /db_xref="GeneID:55632"
                     /db_xref="HGNC:HGNC:20338"
                     /db_xref="MIM:611299"
ORIGIN      
        1 mneskpgdsq nlacvfcrkh ddcpnkygek ktkekwnltv hyycllmssg iwqrgkeeeg
       61 vygfliedir kevnrasklk ccvckkngas igcvaprckr syhfpcglqr ecifqftgnf
      121 asfcwdhrpv qiitsnnyre slpcticlef iepipsynil rspccknawf hrdclqvqai
      181 nagvfffrct icnnsdifqk emlrmgihip enkweikrcq ccgssgthla csslrsweqn
      241 weclecrgii ynsgefqkak khvlpnsnnv gitdcllees spklprqspg sqskdllrqg
      301 skfrrnvstl lielgfqikk ktkrlyinka niwnsaldaf rnrnfnpsya ievayviend
      361 nfgsehpgsk qeflsllmqh lensslfegs lsknlslnsq alkenlyyea gkmlaislvh
      421 ggpspgffsk tlfnclvygp entqpilddv sdfdvaqiii rintattvad lksiinecyn
      481 yleligclrl ittlsdkyml vkdilgyhvi qrvhtpfesf kqglktlgvl ekiqaypeaf
      541 csilchkpes lsakilself tvhtlpdvka lgfwnsylqa vedgkstttm edilifatgc
      601 ssippagfkp tpsieclhvd fpvgnkcnnc laipitntyk efqenmdfti rntlrlekee
      661 sshyigh
//
LOCUS       XP_047287508             621 aa            linear   PRI 05-AUG-2025
DEFINITION  G2/M phase-specific E3 ubiquitin-protein ligase isoform X3 [Homo
            sapiens].
ACCESSION   XP_047287508
VERSION     XP_047287508.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431552.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..621
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..621
                     /product="G2/M phase-specific E3 ubiquitin-protein ligase
                     isoform X3"
                     /calculated_mol_wt=70210
     Region          <1..81
                     /region_name="ePHD_PHF7_G2E3_like"
                     /note="Extended PHD finger found in PHD finger protein 7
                     (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase
                     (G2E3); cd15669"
                     /db_xref="CDD:277139"
     Site            order(34,43..47,53,76)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277139"
     Region          <164..200
                     /region_name="PHD_SF"
                     /note="PHD finger superfamily; cl22851"
                     /db_xref="CDD:473978"
     Site            order(170..173,177,195)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:276966"
     Site            order(283,312,326,379,550,575..576,579..583,603)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Region          326..607
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cl27008"
                     /db_xref="CDD:474882"
     Site            order(421,424..425,427..428,433,440,442,446..447,449,455)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..621
                     /gene="G2E3"
                     /gene_synonym="KIAA1333; PHF7B"
                     /coded_by="XM_047431552.1:217..2082"
                     /db_xref="GeneID:55632"
                     /db_xref="HGNC:HGNC:20338"
                     /db_xref="MIM:611299"
ORIGIN      
        1 mssgiwqrgk eeegvygfli edirkevnra sklkccvckk ngasigcvap rckrsyhfpc
       61 glqrecifqf tgnfasfcwd hrpvqiitsn nyreslpcti clefiepips ynilrspcck
      121 nawfhrdclq vqainagvff frcticnnsd ifqkemlrmg ihipenkwei krcqccgssg
      181 thlacsslrs weqnweclec rgiiynsgef qkakkhvlpn snnvgitdcl leesspklpr
      241 qspgsqskdl lrqgskfrrn vstllielgf qikkktkrly inkaniwnsa ldafrnrnfn
      301 psyaievayv iendnfgseh pgskqeflsl lmqhlenssl fegslsknls lnsqalkenl
      361 yyeagkmlai slvhggpspg ffsktlfncl vygpentqpi lddvsdfdva qiiirintat
      421 tvadlksiin ecynylelig clrlittlsd kymlvkdilg yhviqrvhtp fesfkqglkt
      481 lgvlekiqay peafcsilch kpeslsakil selftvhtlp dvkalgfwns ylqavedgks
      541 tttmedilif atgcssippa gfkptpsiec lhvdfpvgnk cnnclaipit ntykefqenm
      601 dftirntlrl ekeesshyig h
//
LOCUS       XP_047287509             505 aa            linear   PRI 05-AUG-2025
DEFINITION  G2/M phase-specific E3 ubiquitin-protein ligase isoform X4 [Homo
            sapiens].
ACCESSION   XP_047287509
VERSION     XP_047287509.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431553.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..505
                     /product="G2/M phase-specific E3 ubiquitin-protein ligase
                     isoform X4"
                     /calculated_mol_wt=57103
     Region          31..84
                     /region_name="PHD_PHF7_G2E3_like"
                     /note="PHD finger found in PHD finger protein 7 (PHF7) and
                     G2/M phase-specific E3 ubiquitin-protein ligase (G2E3);
                     cd15496"
                     /db_xref="CDD:276971"
     Site            order(31,53..57,61,79)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:276971"
     Site            order(167,196,210,263,434,459..460,463..467,487)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Region          210..491
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cl27008"
                     /db_xref="CDD:474882"
     Site            order(305,308..309,311..312,317,324,326,330..331,333,339)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..505
                     /gene="G2E3"
                     /gene_synonym="KIAA1333; PHF7B"
                     /coded_by="XM_047431553.1:588..2105"
                     /db_xref="GeneID:55632"
                     /db_xref="HGNC:HGNC:20338"
                     /db_xref="MIM:611299"
ORIGIN      
        1 mlrmgihipe kdasweleen ayqellqhye rcdvrrcrck egrdynapds kweikrcqcc
       61 gssgthlacs slrsweqnwe clecrgiiyn sgefqkakkh vlpnsnnvgi tdclleessp
      121 klprqspgsq skdllrqgsk frrnvstlli elgfqikkkt krlyinkani wnsaldafrn
      181 rnfnpsyaie vayviendnf gsehpgskqe flsllmqhle nsslfegsls knlslnsqal
      241 kenlyyeagk mlaislvhgg pspgffsktl fnclvygpen tqpilddvsd fdvaqiiiri
      301 ntattvadlk siinecynyl eligclrlit tlsdkymlvk dilgyhviqr vhtpfesfkq
      361 glktlgvlek iqaypeafcs ilchkpesls akilselftv htlpdvkalg fwnsylqave
      421 dgkstttmed ilifatgcss ippagfkptp sieclhvdfp vgnkcnncla ipitntykef
      481 qenmdftirn tlrlekeess hyigh
//
LOCUS       XP_047287510             344 aa            linear   PRI 05-AUG-2025
DEFINITION  G2/M phase-specific E3 ubiquitin-protein ligase isoform X5 [Homo
            sapiens].
ACCESSION   XP_047287510
VERSION     XP_047287510.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431554.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..344
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..344
                     /product="G2/M phase-specific E3 ubiquitin-protein ligase
                     isoform X5"
                     /calculated_mol_wt=39618
     Region          14..127
                     /region_name="ePHD_PHF7_G2E3_like"
                     /note="Extended PHD finger found in PHD finger protein 7
                     (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase
                     (G2E3); cd15669"
                     /db_xref="CDD:277139"
     Site            order(80,89..93,99,122)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277139"
     Region          232..285
                     /region_name="PHD_PHF7_G2E3_like"
                     /note="PHD finger found in PHD finger protein 7 (PHF7) and
                     G2/M phase-specific E3 ubiquitin-protein ligase (G2E3);
                     cd15496"
                     /db_xref="CDD:276971"
     Site            order(232,254..258,262,280)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:276971"
     CDS             1..344
                     /gene="G2E3"
                     /gene_synonym="KIAA1333; PHF7B"
                     /coded_by="XM_047431554.1:120..1154"
                     /db_xref="GeneID:55632"
                     /db_xref="HGNC:HGNC:20338"
                     /db_xref="MIM:611299"
ORIGIN      
        1 mneskpgdsq nlacvfcrkh ddcpnkygek ktkekwnltv hyycllmssg iwqrgkeeeg
       61 vygfliedir kevnrasklk ccvckkngas igcvaprckr syhfpcglqr ecifqftgnf
      121 asfcwdhrpv qiitsnnyre slpcticlef iepipsynil rspccknawf hrdclqvqai
      181 nagvfffrct icnnsdifqk emlrmgihip ekdaswelee nayqellqhy ercdvrrcrc
      241 kegrdynapd skweikrcqc cgssgthlac sslrsweqnw eclecrgiiy nsgefqkakk
      301 hvlpnsnnvg itdclleess pklprqspgs qskdllsser esll
//
LOCUS       XP_047287511             290 aa            linear   PRI 05-AUG-2025
DEFINITION  G2/M phase-specific E3 ubiquitin-protein ligase isoform X6 [Homo
            sapiens].
ACCESSION   XP_047287511
VERSION     XP_047287511.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431555.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..290
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..290
                     /product="G2/M phase-specific E3 ubiquitin-protein ligase
                     isoform X6"
                     /calculated_mol_wt=32255
     Region          15..276
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cl27008"
                     /db_xref="CDD:474882"
     Site            order(90,93..94,96..97,102,109,111,115..116,118,124)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..290
                     /gene="G2E3"
                     /gene_synonym="KIAA1333; PHF7B"
                     /coded_by="XM_047431555.1:645..1517"
                     /db_xref="GeneID:55632"
                     /db_xref="HGNC:HGNC:20338"
                     /db_xref="MIM:611299"
ORIGIN      
        1 mqhlensslf egslsknlsl nsqalkenly yeagkmlais lvhggpspgf fsktlfnclv
       61 ygpentqpil ddvsdfdvaq iiirintatt vadlksiine cynyleligc lrlittlsdk
      121 ymlvkdilgy hviqrvhtpf esfkqglktl gvlekiqayp eafcsilchk peslsakils
      181 elftvhtlpd vkalgfwnsy lqavedgkst ttmedilifa tgcssippag fkptpsiecl
      241 hvdfpvgnkc nnclaipitn tykefqenmd ftirntlrle keesshyigh
//
LOCUS       XP_047287512             305 aa            linear   PRI 05-AUG-2025
DEFINITION  G2/M phase-specific E3 ubiquitin-protein ligase isoform X7 [Homo
            sapiens].
ACCESSION   XP_047287512
VERSION     XP_047287512.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431556.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..305
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..305
                     /product="G2/M phase-specific E3 ubiquitin-protein ligase
                     isoform X7"
                     /calculated_mol_wt=34873
     Region          14..127
                     /region_name="ePHD_PHF7_G2E3_like"
                     /note="Extended PHD finger found in PHD finger protein 7
                     (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase
                     (G2E3); cd15669"
                     /db_xref="CDD:277139"
     Site            order(80,89..93,99,122)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277139"
     Region          <210..246
                     /region_name="PHD_SF"
                     /note="PHD finger superfamily; cl22851"
                     /db_xref="CDD:473978"
     Site            order(216..219,223,241)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:276966"
     CDS             1..305
                     /gene="G2E3"
                     /gene_synonym="KIAA1333; PHF7B"
                     /coded_by="XM_047431556.1:120..1037"
                     /db_xref="GeneID:55632"
                     /db_xref="HGNC:HGNC:20338"
                     /db_xref="MIM:611299"
ORIGIN      
        1 mneskpgdsq nlacvfcrkh ddcpnkygek ktkekwnltv hyycllmssg iwqrgkeeeg
       61 vygfliedir kevnrasklk ccvckkngas igcvaprckr syhfpcglqr ecifqftgnf
      121 asfcwdhrpv qiitsnnyre slpcticlef iepipsynil rspccknawf hrdclqvqai
      181 nagvfffrct icnnsdifqk emlrmgihip enkweikrcq ccgssgthla csslrsweqn
      241 weclecrgii ynsgefqkak khvlpnsnnv gitdcllees spklprqspg sqskdllsse
      301 resll
//
LOCUS       XP_047287513             259 aa            linear   PRI 05-AUG-2025
DEFINITION  G2/M phase-specific E3 ubiquitin-protein ligase isoform X8 [Homo
            sapiens].
ACCESSION   XP_047287513
VERSION     XP_047287513.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431557.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..259
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..259
                     /product="G2/M phase-specific E3 ubiquitin-protein ligase
                     isoform X8"
                     /calculated_mol_wt=29455
     Region          <1..81
                     /region_name="ePHD_PHF7_G2E3_like"
                     /note="Extended PHD finger found in PHD finger protein 7
                     (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase
                     (G2E3); cd15669"
                     /db_xref="CDD:277139"
     Site            order(34,43..47,53,76)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277139"
     Region          <164..200
                     /region_name="PHD_SF"
                     /note="PHD finger superfamily; cl22851"
                     /db_xref="CDD:473978"
     Site            order(170..173,177,195)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:276966"
     CDS             1..259
                     /gene="G2E3"
                     /gene_synonym="KIAA1333; PHF7B"
                     /coded_by="XM_047431557.1:217..996"
                     /db_xref="GeneID:55632"
                     /db_xref="HGNC:HGNC:20338"
                     /db_xref="MIM:611299"
ORIGIN      
        1 mssgiwqrgk eeegvygfli edirkevnra sklkccvckk ngasigcvap rckrsyhfpc
       61 glqrecifqf tgnfasfcwd hrpvqiitsn nyreslpcti clefiepips ynilrspcck
      121 nawfhrdclq vqainagvff frcticnnsd ifqkemlrmg ihipenkwei krcqccgssg
      181 thlacsslrs weqnweclec rgiiynsgef qkakkhvlpn snnvgitdcl leesspklpr
      241 qspgsqskdl lsseresll
//
LOCUS       XP_016876916             495 aa            linear   PRI 05-AUG-2025
DEFINITION  G patch domain-containing protein 2-like isoform X1 [Homo sapiens].
ACCESSION   XP_016876916
VERSION     XP_016876916.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021427.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..495
                     /product="G patch domain-containing protein 2-like isoform
                     X1"
                     /calculated_mol_wt=55688
     CDS             1..495
                     /gene="GPATCH2L"
                     /gene_synonym="C14orf118"
                     /coded_by="XM_017021427.2:276..1763"
                     /db_xref="GeneID:55668"
                     /db_xref="HGNC:HGNC:20210"
ORIGIN      
        1 mfkfvlfclr cglmdelvhd lasaleqtse qnklgelwee malsprqqrr qlrkrrgrkr
       61 rsdfthlaeh tccyseases sldeatkdcr evapvtnfsd sddtmvakrh palnaivksk
      121 qhswhesdsf tenapcrplr rrrkvkrvts evaaslqqkl kvsdwsyerg crfksakkqr
      181 lsrwkentpw tssghglces aenrtflskt grkermecet deqkqgsden msecetssvc
      241 sssdtglftn degrqgddeq sdwfyegecv pgftvpnllp kwapdhcsev ermdsgldkf
      301 sdstfllpsr paqrgyhtrl nrlpgaaarc lrkgrrrlvg ketsintlgt erishiisdp
      361 rqkeknkala sdfphisaca hefnplsply sldvladash rrcspahcsa rqanvhwgpp
      421 csrdikrkrk pvataslssp savhmdavep ttpasqapks pssewlvrts aaekatdatt
      481 atffkmpqek spgys
//
LOCUS       XP_016876917             490 aa            linear   PRI 05-AUG-2025
DEFINITION  G patch domain-containing protein 2-like isoform X2 [Homo sapiens].
ACCESSION   XP_016876917
VERSION     XP_016876917.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021428.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..490
                     /product="G patch domain-containing protein 2-like isoform
                     X2"
                     /calculated_mol_wt=55323
     CDS             1..490
                     /gene="GPATCH2L"
                     /gene_synonym="C14orf118"
                     /coded_by="XM_017021428.2:276..1748"
                     /db_xref="GeneID:55668"
                     /db_xref="HGNC:HGNC:20210"
ORIGIN      
        1 mfkfvlfclr cglmdelvhd lasaleqtse qnklgelwee malsprqqrr qlrkrrgrkr
       61 rsdfthlaeh tccyseases sldeatkdcr evapvtnfsd sddtmvakrh palnaivksk
      121 qhswhesdsf tenapcrplr rrrkvkrvts evaaslqqkl kvsdwsyerg crfksakkqr
      181 lsrwkentpw tssghglces aenrtflskt grkermecet deqkqgsden msecetssvc
      241 sssdtglftn degrqgddeq sdwfyegecv pgftvpnllp kwapdhcsev ermdsgldkf
      301 sdstfllpsr paqrgyhtrl nrlpgaaarc lrkgrrrlvg ketsintlgt erishiisdp
      361 rqkdfwlpsa gkrernqfnp lsplysldvl adashrrcsp ahcsarqanv hwgppcsrdi
      421 krkrkpvata slsspsavhm davepttpas qapkspssew lvrtsaaeka tdattatffk
      481 mpqekspgys
//
LOCUS       XP_016876918             482 aa            linear   PRI 05-AUG-2025
DEFINITION  G patch domain-containing protein 2-like isoform X3 [Homo sapiens].
ACCESSION   XP_016876918
VERSION     XP_016876918.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021429.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..482
                     /product="G patch domain-containing protein 2-like isoform
                     X3"
                     /calculated_mol_wt=54444
     CDS             1..482
                     /gene="GPATCH2L"
                     /gene_synonym="C14orf118"
                     /coded_by="XM_017021429.2:276..1724"
                     /db_xref="GeneID:55668"
                     /db_xref="HGNC:HGNC:20210"
ORIGIN      
        1 mfkfvlfclr cglmdelvhd lasaleqtse qnklgelwee malsprqqrr qlrkrrgrkr
       61 rsdfthlaeh tccyseases sldeatkdcr evapvtnfsd sddtmvakrh palnaivksk
      121 qhswhesdsf tenapcrplr rrrkvkrvts evaaslqqkl kvsdwsyerg crfksakkqr
      181 lsrwkentpw tssghglces aenrtflskt grkermecet deqkqgsden msecetssvc
      241 sssdtglftn degrqgddeq sdwfyegecv pgftvpnllp kwapdhcsev ermdsgldkf
      301 sdstfllpsr paqrgyhtrl nrlpgaaarc lrkgrrrlvg ketsintlgt erishiisdp
      361 rqkeknkala sdfphisaca hefnplsply sldvladash rrcspahcsa rqanvhwgpp
      421 csrdikrkrk pvataslssp sagmsdeerw vplcrcinth qgpapstksr ygihllsdss
      481 pv
//
LOCUS       XP_016876919             477 aa            linear   PRI 05-AUG-2025
DEFINITION  G patch domain-containing protein 2-like isoform X4 [Homo sapiens].
ACCESSION   XP_016876919
VERSION     XP_016876919.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021430.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..477
                     /product="G patch domain-containing protein 2-like isoform
                     X4"
                     /calculated_mol_wt=54080
     CDS             1..477
                     /gene="GPATCH2L"
                     /gene_synonym="C14orf118"
                     /coded_by="XM_017021430.2:276..1709"
                     /db_xref="GeneID:55668"
                     /db_xref="HGNC:HGNC:20210"
ORIGIN      
        1 mfkfvlfclr cglmdelvhd lasaleqtse qnklgelwee malsprqqrr qlrkrrgrkr
       61 rsdfthlaeh tccyseases sldeatkdcr evapvtnfsd sddtmvakrh palnaivksk
      121 qhswhesdsf tenapcrplr rrrkvkrvts evaaslqqkl kvsdwsyerg crfksakkqr
      181 lsrwkentpw tssghglces aenrtflskt grkermecet deqkqgsden msecetssvc
      241 sssdtglftn degrqgddeq sdwfyegecv pgftvpnllp kwapdhcsev ermdsgldkf
      301 sdstfllpsr paqrgyhtrl nrlpgaaarc lrkgrrrlvg ketsintlgt erishiisdp
      361 rqkdfwlpsa gkrernqfnp lsplysldvl adashrrcsp ahcsarqanv hwgppcsrdi
      421 krkrkpvata slsspsagms deerwvplcr cinthqgpap stksrygihl lsdsspv
//
LOCUS       XP_016876920             460 aa            linear   PRI 05-AUG-2025
DEFINITION  G patch domain-containing protein 2-like isoform X5 [Homo sapiens].
ACCESSION   XP_016876920
VERSION     XP_016876920.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021431.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..460
                     /product="G patch domain-containing protein 2-like isoform
                     X5"
                     /calculated_mol_wt=51907
     CDS             1..460
                     /gene="GPATCH2L"
                     /gene_synonym="C14orf118"
                     /coded_by="XM_017021431.2:276..1658"
                     /db_xref="GeneID:55668"
                     /db_xref="HGNC:HGNC:20210"
ORIGIN      
        1 mfkfvlfclr cglmdelvhd lasaleqtse qnklgelwee malsprqqrr qlrkrrgrkr
       61 rsdfthlaeh tccyseases sldeatkdcr evapvtnfsd sddtmvakrh palnaivksk
      121 qhswhesdsf tenapcrplr rrrkvkrvts evaaslqqkl kvsdwsyerg crfksakkqr
      181 lsrwkentpw tssghglces aenrtflskt grkermecet deqkqgsden msecetssvc
      241 sssdtglftn degrqgddeq sdwfyegecv pgftvpnllp kwapdhcsev ermdsgldkf
      301 sdstfllpsr paqrgyhtrl nrlpgaaarc lrkgrrrlvg ketsintlgt erishiisdp
      361 rqkeknkala sdfphisaca hefnplsply sldvladash rrcspahcsa rqanvhwgpp
      421 csrdikrkrk pvataslssp saaalftvvk vetnhmsiag
//
LOCUS       XP_047287514             455 aa            linear   PRI 05-AUG-2025
DEFINITION  G patch domain-containing protein 2-like isoform X6 [Homo sapiens].
ACCESSION   XP_047287514
VERSION     XP_047287514.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431558.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..455
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..455
                     /product="G patch domain-containing protein 2-like isoform
                     X6"
                     /calculated_mol_wt=51542
     CDS             1..455
                     /gene="GPATCH2L"
                     /gene_synonym="C14orf118"
                     /coded_by="XM_047431558.1:276..1643"
                     /db_xref="GeneID:55668"
                     /db_xref="HGNC:HGNC:20210"
ORIGIN      
        1 mfkfvlfclr cglmdelvhd lasaleqtse qnklgelwee malsprqqrr qlrkrrgrkr
       61 rsdfthlaeh tccyseases sldeatkdcr evapvtnfsd sddtmvakrh palnaivksk
      121 qhswhesdsf tenapcrplr rrrkvkrvts evaaslqqkl kvsdwsyerg crfksakkqr
      181 lsrwkentpw tssghglces aenrtflskt grkermecet deqkqgsden msecetssvc
      241 sssdtglftn degrqgddeq sdwfyegecv pgftvpnllp kwapdhcsev ermdsgldkf
      301 sdstfllpsr paqrgyhtrl nrlpgaaarc lrkgrrrlvg ketsintlgt erishiisdp
      361 rqkdfwlpsa gkrernqfnp lsplysldvl adashrrcsp ahcsarqanv hwgppcsrdi
      421 krkrkpvata slsspsaaal ftvvkvetnh msiag
//
LOCUS       XP_047287515             451 aa            linear   PRI 05-AUG-2025
DEFINITION  G patch domain-containing protein 2-like isoform X7 [Homo sapiens].
ACCESSION   XP_047287515
VERSION     XP_047287515.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431559.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..451
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..451
                     /product="G patch domain-containing protein 2-like isoform
                     X7"
                     /calculated_mol_wt=50942
     CDS             1..451
                     /gene="GPATCH2L"
                     /gene_synonym="C14orf118"
                     /coded_by="XM_047431559.1:276..1631"
                     /db_xref="GeneID:55668"
                     /db_xref="HGNC:HGNC:20210"
ORIGIN      
        1 mfkfvlfclr cglmdelvhd lasaleqtse qnklgelwee malsprqqrr qlrkrrgrkr
       61 rsdfthlaeh tccyseases sldeatkdcr evapvtnfsd sddtmvakrh palnaivksk
      121 qhswhesdsf tenapcrplr rrrkvkrvts evaaslqqkl kvsdwsyerg crfksakkqr
      181 lsrwkentpw tssghglces aenrtflskt grkermecet deqkqgsden msecetssvc
      241 sssdtglftn degrqgddeq sdwfyegecv pgftvpnllp kwapdhcsev ermdsgldkf
      301 sdstfllpsr paqrgyhtrl nrlpgaaarc lrkgrrrlvg ketsintlgt erishiisdp
      361 rqkeknkala sdfphisaca hefnplsply sldvladash rrcspahcsa rqanvhwgpp
      421 csrdikrkrk pvataslssp saggrrtapl p
//
LOCUS       XP_047287516             394 aa            linear   PRI 05-AUG-2025
DEFINITION  G patch domain-containing protein 2-like isoform X8 [Homo sapiens].
ACCESSION   XP_047287516
VERSION     XP_047287516.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431560.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..394
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..394
                     /product="G patch domain-containing protein 2-like isoform
                     X8"
                     /calculated_mol_wt=44784
     CDS             1..394
                     /gene="GPATCH2L"
                     /gene_synonym="C14orf118"
                     /coded_by="XM_047431560.1:276..1460"
                     /db_xref="GeneID:55668"
                     /db_xref="HGNC:HGNC:20210"
ORIGIN      
        1 mfkfvlfclr cglmdelvhd lasaleqtse qnklgelwee malsprqqrr qlrkrrgrkr
       61 rsdfthlaeh tccyseases sldeatkdcr evapvtnfsd sddtmvakrh palnaivksk
      121 qhswhesdsf tenapcrplr rrrkvkrvts evaaslqqkl kvsdwsyerg crfksakkqr
      181 lsrwkentpw tssghglces aenrtflskt grkermecet deqkqgsden msecetssvc
      241 sssdtglftn degrqgddeq sdwfyegecv pgftvpnllp kwapdhcsev ermdsgldkf
      301 sdstfllpsr paqrgyhtrl nrlpgaaarc lrkgrrrlvg ketsintlgt erishiisdp
      361 rqkeknkala sdfphisaca hetgkctlgt tmft
//
LOCUS       XP_005267899             833 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 4 regulatory subunit 3A
            isoform X1 [Homo sapiens].
ACCESSION   XP_005267899
VERSION     XP_005267899.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267842.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..833
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..833
                     /product="serine/threonine-protein phosphatase 4
                     regulatory subunit 3A isoform X1"
                     /calculated_mol_wt=95238
     Region          7..>65
                     /region_name="PH-like"
                     /note="Pleckstrin homology-like domain; cl17171"
                     /db_xref="CDD:473070"
     Region          166..357
                     /region_name="PP4R3"
                     /note="Phosphatase 4 regulatory subunit 3; pfam04802"
                     /db_xref="CDD:461435"
     CDS             1..833
                     /gene="PPP4R3A"
                     /gene_synonym="FLFL1; KIAA2010; MSTP033; PP4R3; PP4R3A;
                     SMEK1; smk-1; smk1"
                     /coded_by="XM_005267842.3:84..2585"
                     /db_xref="GeneID:55671"
                     /db_xref="HGNC:HGNC:20219"
                     /db_xref="MIM:610351"
ORIGIN      
        1 mtdtrrrvkv ytlnedrqwd drgtghvssg yverlkgmsl lvraesdgsl lleskinpnt
       61 ayqkqqdtli vwseaenydl alsfqekagc deiwekicqv qgkdpsvdit qdlvdeseee
      121 rfddmsspgl elpscelsrl eeiaelvass lpsplrrekl alalenegyi kkllelfhvc
      181 edlenieglh hlyeiikgif llnrtalfev mfseecimdv igcleydpal sqprkhrefl
      241 tktakfkevi pisdpelkqk ihqtyrvqyi qdmvlptpsv feenmlstlh sfiffnkvei
      301 vgmlqedekf ltdlfaqltd eatdeekrqe lvnflkefca fsqtlqpqnr daffktlsnm
      361 gilpalevil gmddtqvrsa atdifsylve ynpsmvrefv mqeaqqnddv skklteqkit
      421 skdillinli iehmicdtdp elggavqlmg llrtlvdpen mlatanktek teflgffykh
      481 cmhvltapll anttedkpsk ddfqtaqlla lvlelltfcv ehhtyhikny iinkdilrrv
      541 lvlmaskhaf lalcalrfkr kiiglkdefy nryimksflf epvvkaflnn gsrynlmnsa
      601 iiemfefirv ediksltahv ienywkaled vdyvqtfkgl klrfeqqrer qdnpkldsmr
      661 silrnhryrr dartledeee mwfntdeddm edgeavvsps dktkndddim dpiskfmerk
      721 klkeseekev llktnlsgrq spsfklslss gtktnltsqs sttnlpgspg spgspgspgs
      781 pgsvpkntsq taaittkggl vglvdypddd edddededke dtlplskkak fds
//
LOCUS       XP_047287517             820 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 4 regulatory subunit 3A
            isoform X2 [Homo sapiens].
ACCESSION   XP_047287517
VERSION     XP_047287517.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431561.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..820
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..820
                     /product="serine/threonine-protein phosphatase 4
                     regulatory subunit 3A isoform X2"
                     /calculated_mol_wt=93766
     Region          7..>65
                     /region_name="PH-like"
                     /note="Pleckstrin homology-like domain; cl17171"
                     /db_xref="CDD:473070"
     Region          166..357
                     /region_name="PP4R3"
                     /note="Phosphatase 4 regulatory subunit 3; pfam04802"
                     /db_xref="CDD:461435"
     Region          <325..402
                     /region_name="LPD_N"
                     /note="Lipoprotein N-terminal Domain; smart00638"
                     /db_xref="CDD:214755"
     CDS             1..820
                     /gene="PPP4R3A"
                     /gene_synonym="FLFL1; KIAA2010; MSTP033; PP4R3; PP4R3A;
                     SMEK1; smk-1; smk1"
                     /coded_by="XM_047431561.1:84..2546"
                     /db_xref="GeneID:55671"
                     /db_xref="HGNC:HGNC:20219"
                     /db_xref="MIM:610351"
ORIGIN      
        1 mtdtrrrvkv ytlnedrqwd drgtghvssg yverlkgmsl lvraesdgsl lleskinpnt
       61 ayqkqqdtli vwseaenydl alsfqekagc deiwekicqv qgkdpsvdit qdlvdeseee
      121 rfddmsspgl elpscelsrl eeiaelvass lpsplrrekl alalenegyi kkllelfhvc
      181 edlenieglh hlyeiikgif llnrtalfev mfseecimdv igcleydpal sqprkhrefl
      241 tktakfkevi pisdpelkqk ihqtyrvqyi qdmvlptpsv feenmlstlh sfiffnkvei
      301 vgmlqedekf ltdlfaqltd eatdeekrqe lvnflkefca fsqtlqpqnr daffktlsnm
      361 gilpalevil gmddtqvrsa atdifsylve ynpsmvrefv mqeaqqnddd illinliieh
      421 micdtdpelg gavqlmgllr tlvdpenmla tanktektef lgffykhcmh vltapllant
      481 tedkpskddf qtaqllalvl elltfcvehh tyhiknyiin kdilrrvlvl maskhaflal
      541 calrfkrkii glkdefynry imksflfepv vkaflnngsr ynlmnsaiie mfefirvedi
      601 ksltahvien ywkaledvdy vqtfkglklr feqqrerqdn pkldsmrsil rnhryrrdar
      661 tledeeemwf ntdeddmedg eavvspsdkt kndddimdpi skfmerkklk eseekevllk
      721 tnlsgrqsps fklslssgtk tnltsqsstt nlpgspgspg spgspgspgs vpkntsqtaa
      781 ittkgglvgl vdypdddedd dededkedtl plskkakfds
//
LOCUS       XP_047287518             553 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 4 regulatory subunit 3A
            isoform X3 [Homo sapiens].
ACCESSION   XP_047287518
VERSION     XP_047287518.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431562.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..553
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..553
                     /product="serine/threonine-protein phosphatase 4
                     regulatory subunit 3A isoform X3"
                     /calculated_mol_wt=63361
     Region          7..>65
                     /region_name="PH-like"
                     /note="Pleckstrin homology-like domain; cl17171"
                     /db_xref="CDD:473070"
     Region          166..357
                     /region_name="PP4R3"
                     /note="Phosphatase 4 regulatory subunit 3; pfam04802"
                     /db_xref="CDD:461435"
     Region          <325..402
                     /region_name="LPD_N"
                     /note="Lipoprotein N-terminal Domain; smart00638"
                     /db_xref="CDD:214755"
     CDS             1..553
                     /gene="PPP4R3A"
                     /gene_synonym="FLFL1; KIAA2010; MSTP033; PP4R3; PP4R3A;
                     SMEK1; smk-1; smk1"
                     /coded_by="XM_047431562.1:664..2325"
                     /db_xref="GeneID:55671"
                     /db_xref="HGNC:HGNC:20219"
                     /db_xref="MIM:610351"
ORIGIN      
        1 mtdtrrrvkv ytlnedrqwd drgtghvssg yverlkgmsl lvraesdgsl lleskinpnt
       61 ayqkqqdtli vwseaenydl alsfqekagc deiwekicqv qgkdpsvdit qdlvdeseee
      121 rfddmsspgl elpscelsrl eeiaelvass lpsplrrekl alalenegyi kkllelfhvc
      181 edlenieglh hlyeiikgif llnrtalfev mfseecimdv igcleydpal sqprkhrefl
      241 tktakfkevi pisdpelkqk ihqtyrvqyi qdmvlptpsv feenmlstlh sfiffnkvei
      301 vgmlqedekf ltdlfaqltd eatdeekrqe lvnflkefca fsqtlqpqnr daffktlsnm
      361 gilpalevil gmddtqvrsa atdifsylve ynpsmvrefv mqeaqqnddv skklteqkit
      421 skdillinli iehmicdtdp elggavqlmg llrtlvdpen mlatanktek teflgffykh
      481 cmhvltapll anttedkpsk ddfqtaqlla lvlelltfcv ehhtyhikny iinkdilrrv
      541 lvlmaskhaf lal
//
LOCUS       XP_047287519             553 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 4 regulatory subunit 3A
            isoform X4 [Homo sapiens].
ACCESSION   XP_047287519
VERSION     XP_047287519.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431563.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..553
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..553
                     /product="serine/threonine-protein phosphatase 4
                     regulatory subunit 3A isoform X4"
                     /calculated_mol_wt=63361
     Region          7..>65
                     /region_name="PH-like"
                     /note="Pleckstrin homology-like domain; cl17171"
                     /db_xref="CDD:473070"
     Region          166..357
                     /region_name="PP4R3"
                     /note="Phosphatase 4 regulatory subunit 3; pfam04802"
                     /db_xref="CDD:461435"
     Region          <325..402
                     /region_name="LPD_N"
                     /note="Lipoprotein N-terminal Domain; smart00638"
                     /db_xref="CDD:214755"
     CDS             1..553
                     /gene="PPP4R3A"
                     /gene_synonym="FLFL1; KIAA2010; MSTP033; PP4R3; PP4R3A;
                     SMEK1; smk-1; smk1"
                     /coded_by="XM_047431563.1:664..2325"
                     /db_xref="GeneID:55671"
                     /db_xref="HGNC:HGNC:20219"
                     /db_xref="MIM:610351"
ORIGIN      
        1 mtdtrrrvkv ytlnedrqwd drgtghvssg yverlkgmsl lvraesdgsl lleskinpnt
       61 ayqkqqdtli vwseaenydl alsfqekagc deiwekicqv qgkdpsvdit qdlvdeseee
      121 rfddmsspgl elpscelsrl eeiaelvass lpsplrrekl alalenegyi kkllelfhvc
      181 edlenieglh hlyeiikgif llnrtalfev mfseecimdv igcleydpal sqprkhrefl
      241 tktakfkevi pisdpelkqk ihqtyrvqyi qdmvlptpsv feenmlstlh sfiffnkvei
      301 vgmlqedekf ltdlfaqltd eatdeekrqe lvnflkefca fsqtlqpqnr daffktlsnm
      361 gilpalevil gmddtqvrsa atdifsylve ynpsmvrefv mqeaqqnddv skklteqkit
      421 skdillinli iehmicdtdp elggavqlmg llrtlvdpen mlatanktek teflgffykh
      481 cmhvltapll anttedkpsk ddfqtaqlla lvlelltfcv ehhtyhikny iinkdilrrv
      541 lvlmaskhaf lal
//
LOCUS       XP_011535239            1523 aa            linear   PRI 05-AUG-2025
DEFINITION  rho guanine nucleotide exchange factor 40 isoform X1 [Homo
            sapiens].
ACCESSION   XP_011535239
VERSION     XP_011535239.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536937.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1523
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1523
                     /product="rho guanine nucleotide exchange factor 40
                     isoform X1"
                     /calculated_mol_wt=164870
     Region          786..964
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cl02488"
                     /db_xref="CDD:413338"
     Site            871..876
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1090..1245
                     /region_name="RhoGEF"
                     /note="RhoGEF domain; pfam00621"
                     /db_xref="CDD:459876"
     Region          1244..1379
                     /region_name="PH_puratrophin-1"
                     /note="Puratrophin-1 pleckstrin homology (PH) domain;
                     cd13242"
                     /db_xref="CDD:270062"
     CDS             1..1523
                     /gene="ARHGEF40"
                     /gene_synonym="SOLO"
                     /coded_by="XM_011536937.4:94..4665"
                     /db_xref="GeneID:55701"
                     /db_xref="HGNC:HGNC:25516"
                     /db_xref="MIM:610018"
ORIGIN      
        1 mepepvedcv qstlaalypp feataptllg qvfqvverty redalrytld flvpakhlla
       61 kvqqeacaqy sgflffhegw plclheqvvv qlaalpwqll rpgdfylqvv psaaqaprla
      121 lkclapgggr vqevpvpnea caylftpewl qginkdrptg rlstcllsap sgiqrlpwae
      181 licprfvhke glmvghqpst lppelpsgpp glpspplpee algtrspgdg hnapvegpeg
      241 eyvellevtl pvrgsptdae gspglsrvrt vptrkgaggk grhrrhrawm hqkglgprgq
      301 dgarppgegs stgaspespp gaeavpeaav levseppaea vgeasgscpl rpgelrgggg
      361 ggqgaegppg tprrtgkgnr rkkraagrga lsrggdsapl spgdkedash qealgnlpsp
      421 sehklpechl vkeeyegsgk pesepkelkt agekepqlse acgpteegag erelegpgll
      481 cmaghtgpeg plsdtptppl etvqegkgdn ipeealavsv sdhpdvawdl masgfliltg
      541 gvdqsgrall titppcppee pppsrdtlnt tlhylhsllr pdlqtlglsv lldlrqappl
      601 ppalipalsq lqdsgdpplv qrllilihdd lptelcgfqg aevlsendlk rvakpeelqw
      661 elgghrdpsp shwveihqev vrlcrlcqgv lgsvrqaiee legaaepeee eavgmpkplq
      721 kvladprlta lqrdggailm rlrstpsskl egqgpatlyq evdeaihqlv rlsnlhvqqq
      781 eqrqclrrlq qvlqwlsgpg eeqlasfamp gdtlsalqet elrfrafsae vqerlaqare
      841 alaleenats qkvldifeqr leqvesglhr alrlqrffqq ahewvdegfa rlagagpgre
      901 avlaalalrr apepsagtfq emralaldlg spaalrewgr cqarcqeler riqqhvgeea
      961 sprgyrrrra dgassggaqw gprspspsls slllpsspgp rpapshcsla pcgedyeeeg
     1021 pelapeaegr ppravlirgl evtstevvdr tcsprehvll grargpdgpw gvgtprmerk
     1081 rsisaqqrlv seliaceqdy vatlsepvpp pgpeltpelr gtwaaalsar erlrsfhrth
     1141 flrelqgcat hplrigacfl rhgdqfslya qyvkhrhkle nglaalspls kgsmeagpyl
     1201 pralqqpleq ltrygrllee llreagpels secralgaav qllreqearg rdllaveavr
     1261 gceidlkeqg qllhrdpftv icgrkkclrh vflfehlllf sklkgpeggs emfvykqafk
     1321 tadmglteni gdsglcfelw frrrrareay tlqatspeik lkwtssiaql lwrqaahnke
     1381 lrvqqmvsmg ignkpfldik algertlsal ltgraartra svavssfeha gpslpglspg
     1441 acslparvee eawdldvkqi slaspsapet ldssgdvspg prnspslqpp hpgsstptla
     1501 srgilglsrq sharalsdpt tpl
//
LOCUS       XP_047287520            1475 aa            linear   PRI 05-AUG-2025
DEFINITION  rho guanine nucleotide exchange factor 40 isoform X2 [Homo
            sapiens].
ACCESSION   XP_047287520
VERSION     XP_047287520.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431564.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1475
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1475
                     /product="rho guanine nucleotide exchange factor 40
                     isoform X2"
                     /calculated_mol_wt=159910
     Region          786..964
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cl02488"
                     /db_xref="CDD:413338"
     Site            871..876
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1090..1245
                     /region_name="RhoGEF"
                     /note="RhoGEF domain; pfam00621"
                     /db_xref="CDD:459876"
     Region          1244..1379
                     /region_name="PH_puratrophin-1"
                     /note="Puratrophin-1 pleckstrin homology (PH) domain;
                     cd13242"
                     /db_xref="CDD:270062"
     CDS             1..1475
                     /gene="ARHGEF40"
                     /gene_synonym="SOLO"
                     /coded_by="XM_047431564.1:94..4521"
                     /db_xref="GeneID:55701"
                     /db_xref="HGNC:HGNC:25516"
                     /db_xref="MIM:610018"
ORIGIN      
        1 mepepvedcv qstlaalypp feataptllg qvfqvverty redalrytld flvpakhlla
       61 kvqqeacaqy sgflffhegw plclheqvvv qlaalpwqll rpgdfylqvv psaaqaprla
      121 lkclapgggr vqevpvpnea caylftpewl qginkdrptg rlstcllsap sgiqrlpwae
      181 licprfvhke glmvghqpst lppelpsgpp glpspplpee algtrspgdg hnapvegpeg
      241 eyvellevtl pvrgsptdae gspglsrvrt vptrkgaggk grhrrhrawm hqkglgprgq
      301 dgarppgegs stgaspespp gaeavpeaav levseppaea vgeasgscpl rpgelrgggg
      361 ggqgaegppg tprrtgkgnr rkkraagrga lsrggdsapl spgdkedash qealgnlpsp
      421 sehklpechl vkeeyegsgk pesepkelkt agekepqlse acgpteegag erelegpgll
      481 cmaghtgpeg plsdtptppl etvqegkgdn ipeealavsv sdhpdvawdl masgfliltg
      541 gvdqsgrall titppcppee pppsrdtlnt tlhylhsllr pdlqtlglsv lldlrqappl
      601 ppalipalsq lqdsgdpplv qrllilihdd lptelcgfqg aevlsendlk rvakpeelqw
      661 elgghrdpsp shwveihqev vrlcrlcqgv lgsvrqaiee legaaepeee eavgmpkplq
      721 kvladprlta lqrdggailm rlrstpsskl egqgpatlyq evdeaihqlv rlsnlhvqqq
      781 eqrqclrrlq qvlqwlsgpg eeqlasfamp gdtlsalqet elrfrafsae vqerlaqare
      841 alaleenats qkvldifeqr leqvesglhr alrlqrffqq ahewvdegfa rlagagpgre
      901 avlaalalrr apepsagtfq emralaldlg spaalrewgr cqarcqeler riqqhvgeea
      961 sprgyrrrra dgassggaqw gprspspsls slllpsspgp rpapshcsla pcgedyeeeg
     1021 pelapeaegr ppravlirgl evtstevvdr tcsprehvll grargpdgpw gvgtprmerk
     1081 rsisaqqrlv seliaceqdy vatlsepvpp pgpeltpelr gtwaaalsar erlrsfhrth
     1141 flrelqgcat hplrigacfl rhgdqfslya qyvkhrhkle nglaalspls kgsmeagpyl
     1201 pralqqpleq ltrygrllee llreagpels secralgaav qllreqearg rdllaveavr
     1261 gceidlkeqg qllhrdpftv icgrkkclrh vflfehlllf sklkgpeggs emfvykqafk
     1321 tadmglteni gdsglcfelw frrrrareay tlqatspeik lkwtssiaql lwrqaahnke
     1381 lrvqqmvsmg ignkpfldik algertlsal ltgraspsap etldssgdvs pgprnspslq
     1441 pphpgsstpt lasrgilgls rqsharalsd pttpl
//
LOCUS       XP_005267901            1471 aa            linear   PRI 05-AUG-2025
DEFINITION  rho guanine nucleotide exchange factor 40 isoform X3 [Homo
            sapiens].
ACCESSION   XP_005267901
VERSION     XP_005267901.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267844.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1471
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1471
                     /product="rho guanine nucleotide exchange factor 40
                     isoform X3"
                     /calculated_mol_wt=159568
     Region          786..964
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cl02488"
                     /db_xref="CDD:413338"
     Site            871..876
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1090..1245
                     /region_name="RhoGEF"
                     /note="RhoGEF domain; pfam00621"
                     /db_xref="CDD:459876"
     Region          1244..1379
                     /region_name="PH_puratrophin-1"
                     /note="Puratrophin-1 pleckstrin homology (PH) domain;
                     cd13242"
                     /db_xref="CDD:270062"
     CDS             1..1471
                     /gene="ARHGEF40"
                     /gene_synonym="SOLO"
                     /coded_by="XM_005267844.4:94..4509"
                     /db_xref="GeneID:55701"
                     /db_xref="HGNC:HGNC:25516"
                     /db_xref="MIM:610018"
ORIGIN      
        1 mepepvedcv qstlaalypp feataptllg qvfqvverty redalrytld flvpakhlla
       61 kvqqeacaqy sgflffhegw plclheqvvv qlaalpwqll rpgdfylqvv psaaqaprla
      121 lkclapgggr vqevpvpnea caylftpewl qginkdrptg rlstcllsap sgiqrlpwae
      181 licprfvhke glmvghqpst lppelpsgpp glpspplpee algtrspgdg hnapvegpeg
      241 eyvellevtl pvrgsptdae gspglsrvrt vptrkgaggk grhrrhrawm hqkglgprgq
      301 dgarppgegs stgaspespp gaeavpeaav levseppaea vgeasgscpl rpgelrgggg
      361 ggqgaegppg tprrtgkgnr rkkraagrga lsrggdsapl spgdkedash qealgnlpsp
      421 sehklpechl vkeeyegsgk pesepkelkt agekepqlse acgpteegag erelegpgll
      481 cmaghtgpeg plsdtptppl etvqegkgdn ipeealavsv sdhpdvawdl masgfliltg
      541 gvdqsgrall titppcppee pppsrdtlnt tlhylhsllr pdlqtlglsv lldlrqappl
      601 ppalipalsq lqdsgdpplv qrllilihdd lptelcgfqg aevlsendlk rvakpeelqw
      661 elgghrdpsp shwveihqev vrlcrlcqgv lgsvrqaiee legaaepeee eavgmpkplq
      721 kvladprlta lqrdggailm rlrstpsskl egqgpatlyq evdeaihqlv rlsnlhvqqq
      781 eqrqclrrlq qvlqwlsgpg eeqlasfamp gdtlsalqet elrfrafsae vqerlaqare
      841 alaleenats qkvldifeqr leqvesglhr alrlqrffqq ahewvdegfa rlagagpgre
      901 avlaalalrr apepsagtfq emralaldlg spaalrewgr cqarcqeler riqqhvgeea
      961 sprgyrrrra dgassggaqw gprspspsls slllpsspgp rpapshcsla pcgedyeeeg
     1021 pelapeaegr ppravlirgl evtstevvdr tcsprehvll grargpdgpw gvgtprmerk
     1081 rsisaqqrlv seliaceqdy vatlsepvpp pgpeltpelr gtwaaalsar erlrsfhrth
     1141 flrelqgcat hplrigacfl rhgdqfslya qyvkhrhkle nglaalspls kgsmeagpyl
     1201 pralqqpleq ltrygrllee llreagpels secralgaav qllreqearg rdllaveavr
     1261 gceidlkeqg qllhrdpftv icgrkkclrh vflfehlllf sklkgpeggs emfvykqafk
     1321 tadmglteni gdsglcfelw frrrrareay tlqatspeik lkwtssiaql lwrqaahnke
     1381 lrvqqmvsmg ignkpfldik algertlsal ltgrapetld ssgdvspgpr nspslqpphp
     1441 gsstptlasr gilglsrqsh aralsdpttp l
//
LOCUS       XP_016876923            1331 aa            linear   PRI 05-AUG-2025
DEFINITION  rho guanine nucleotide exchange factor 40 isoform X4 [Homo
            sapiens].
ACCESSION   XP_016876923
VERSION     XP_016876923.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021434.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1331
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1331
                     /product="rho guanine nucleotide exchange factor 40
                     isoform X4"
                     /calculated_mol_wt=143492
     Region          594..772
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cl02488"
                     /db_xref="CDD:413338"
     Site            679..684
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          898..1053
                     /region_name="RhoGEF"
                     /note="RhoGEF domain; pfam00621"
                     /db_xref="CDD:459876"
     Region          1052..1187
                     /region_name="PH_puratrophin-1"
                     /note="Puratrophin-1 pleckstrin homology (PH) domain;
                     cd13242"
                     /db_xref="CDD:270062"
     CDS             1..1331
                     /gene="ARHGEF40"
                     /gene_synonym="SOLO"
                     /coded_by="XM_017021434.3:1019..5014"
                     /db_xref="GeneID:55701"
                     /db_xref="HGNC:HGNC:25516"
                     /db_xref="MIM:610018"
ORIGIN      
        1 mvghqpstlp pelpsgppgl pspplpeeal gtrspgdghn apvegpegey vellevtlpv
       61 rgsptdaegs pglsrvrtvp trkgaggkgr hrrhrawmhq kglgprgqdg arppgegsst
      121 gaspesppga eavpeaavle vseppaeavg easgscplrp gelrgggggg qgaegppgtp
      181 rrtgkgnrrk kraagrgals rggdsaplsp gdkedashqe algnlpspse hklpechlvk
      241 eeyegsgkpe sepkelktag ekepqlseac gpteegager elegpgllcm aghtgpegpl
      301 sdtptpplet vqegkgdnip eealavsvsd hpdvawdlma sgfliltggv dqsgrallti
      361 tppcppeepp psrdtlnttl hylhsllrpd lqtlglsvll dlrqapplpp alipalsqlq
      421 dsgdpplvqr llilihddlp telcgfqgae vlsendlkrv akpeelqwel gghrdpspsh
      481 wveihqevvr lcrlcqgvlg svrqaieele gaaepeeeea vgmpkplqkv ladprltalq
      541 rdggailmrl rstpsskleg qgpatlyqev deaihqlvrl snlhvqqqeq rqclrrlqqv
      601 lqwlsgpgee qlasfampgd tlsalqetel rfrafsaevq erlaqareal aleenatsqk
      661 vldifeqrle qvesglhral rlqrffqqah ewvdegfarl agagpgreav laalalrrap
      721 epsagtfqem ralaldlgsp aalrewgrcq arcqelerri qqhvgeeasp rgyrrrradg
      781 assggaqwgp rspspslssl llpsspgprp apshcslapc gedyeeegpe lapeaegrpp
      841 ravlirglev tstevvdrtc sprehvllgr argpdgpwgv gtprmerkrs isaqqrlvse
      901 liaceqdyva tlsepvpppg peltpelrgt waaalsarer lrsfhrthfl relqgcathp
      961 lrigacflrh gdqfslyaqy vkhrhkleng laalsplskg smeagpylpr alqqpleqlt
     1021 rygrlleell reagpelsse cralgaavql lreqeargrd llaveavrgc eidlkeqgql
     1081 lhrdpftvic grkkclrhvf lfehlllfsk lkgpeggsem fvykqafkta dmgltenigd
     1141 sglcfelwfr rrrareaytl qatspeiklk wtssiaqllw rqaahnkelr vqqmvsmgig
     1201 nkpfldikal gertlsallt graartrasv avssfehagp slpglspgac slparveeea
     1261 wdldvkqisl aspsapetld ssgdvspgpr nspslqpphp gsstptlasr gilglsrqsh
     1321 aralsdpttp l
//
LOCUS       XP_011535240             924 aa            linear   PRI 05-AUG-2025
DEFINITION  rho guanine nucleotide exchange factor 40 isoform X5 [Homo
            sapiens].
ACCESSION   XP_011535240
VERSION     XP_011535240.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536938.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..924
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..924
                     /product="rho guanine nucleotide exchange factor 40
                     isoform X5"
                     /calculated_mol_wt=99468
     Region          760..889
                     /region_name="HrpJ"
                     /note="HrpJ-like domain; cl15454"
                     /db_xref="CDD:417714"
     CDS             1..924
                     /gene="ARHGEF40"
                     /gene_synonym="SOLO"
                     /coded_by="XM_011536938.4:94..2868"
                     /db_xref="GeneID:55701"
                     /db_xref="HGNC:HGNC:25516"
                     /db_xref="MIM:610018"
ORIGIN      
        1 mepepvedcv qstlaalypp feataptllg qvfqvverty redalrytld flvpakhlla
       61 kvqqeacaqy sgflffhegw plclheqvvv qlaalpwqll rpgdfylqvv psaaqaprla
      121 lkclapgggr vqevpvpnea caylftpewl qginkdrptg rlstcllsap sgiqrlpwae
      181 licprfvhke glmvghqpst lppelpsgpp glpspplpee algtrspgdg hnapvegpeg
      241 eyvellevtl pvrgsptdae gspglsrvrt vptrkgaggk grhrrhrawm hqkglgprgq
      301 dgarppgegs stgaspespp gaeavpeaav levseppaea vgeasgscpl rpgelrgggg
      361 ggqgaegppg tprrtgkgnr rkkraagrga lsrggdsapl spgdkedash qealgnlpsp
      421 sehklpechl vkeeyegsgk pesepkelkt agekepqlse acgpteegag erelegpgll
      481 cmaghtgpeg plsdtptppl etvqegkgdn ipeealavsv sdhpdvawdl masgfliltg
      541 gvdqsgrall titppcppee pppsrdtlnt tlhylhsllr pdlqtlglsv lldlrqappl
      601 ppalipalsq lqdsgdpplv qrllilihdd lptelcgfqg aevlsendlk rvakpeelqw
      661 elgghrdpsp shwveihqev vrlcrlcqgv lgsvrqaiee legaaepeee eavgmpkplq
      721 kvladprlta lqrdggailm rlrstpsskl egqgpatlyq evdeaihqlv rlsnlhvqqq
      781 eqrqclrrlq qvlqwlsgpg eeqlasfamp gdtlsalqet elrfrafsae vqerlaqare
      841 alaleenats qkvldifeqr leqvesglhr alrlqrffqq alpspyqlrv twlgsdggtv
      901 rkqesdghwe atgkrtravt ghps
//
LOCUS       XP_047287521            1132 aa            linear   PRI 05-AUG-2025
DEFINITION  BTB/POZ domain-containing protein 7 isoform X1 [Homo sapiens].
ACCESSION   XP_047287521
VERSION     XP_047287521.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431565.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1132
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1132
                     /product="BTB/POZ domain-containing protein 7 isoform X1"
                     /calculated_mol_wt=126238
     Region          140..231
                     /region_name="BTB1_POZ_BTBD7"
                     /note="first BTB (Broad-Complex, Tramtrack and Bric a
                     brac)/POZ (poxvirus and zinc finger) domain found in
                     BTB/POZ domain-containing protein 7 (BTBD7); cd18283"
                     /db_xref="CDD:349592"
     Region          245..392
                     /region_name="BTB2_POZ_BTBD7"
                     /note="second BTB (Broad-Complex, Tramtrack and Bric a
                     brac)/POZ (poxvirus and zinc finger) domain found in
                     BTB/POZ domain-containing protein 7 (BTBD7); cd18284"
                     /db_xref="CDD:349593"
     Region          397..494
                     /region_name="BACK_BTBD7"
                     /note="BACK (BTB and C-terminal Kelch) domain found in
                     BTB/POZ domain-containing protein 7 (BTBD7); cd18489"
                     /db_xref="CDD:350564"
     CDS             1..1132
                     /gene="BTBD7"
                     /gene_synonym="FUP1"
                     /coded_by="XM_047431565.1:24135..27533"
                     /db_xref="GeneID:55727"
                     /db_xref="HGNC:HGNC:18269"
                     /db_xref="MIM:610386"
ORIGIN      
        1 mganasnyph scsprvggns qaqqtfigts sysqqgygce sklysldhgh ekpqdkkkrt
       61 sglatlkkkf ikrrksnrsa dhakqmrell sgwdvrdvna lveeyegtsa lkelslqasl
      121 arpeartlqk dmadlyeyky ctdvdlifqe tcfpvhrail aarcpffktl lssspeygae
      181 iimdintagi dmpmfsallh ylytgefgme dsrfqnvdil vqlseefgtp nsldvdmrgl
      241 fdymcyydvv lsfssdselv eafggnqncl deelkahkav isarspffrn llqrrirtge
      301 eitdrtlrtp triildesii pkkyatvilh cmytdvvdls vlhcspsvgs lsevqalvag
      361 kpnmtraeea melyhialfl efnmlaqgce diiaesisld tliailkwss hpygskwvhr
      421 qalhflceef sqvmtsdvfy elskdhllta iqsdylqase qdilkylikw gehqlmkria
      481 drepnllsgt ahsvnkrgvk rrdldmeelr eilssllpfv riehilpins evlsdamkrg
      541 listppsdml ptteggksna wlrqknagiy vrprlfspyv eeaksvldem mveqtdlvrl
      601 rmvrmsnvpd tlymvnnavp qcchmishqq issnqsspps vvaneipvpr llimkdmvrr
      661 lqelrhteqv qrayalncge gatvsyeiqi rvlrefglad aaaellqnph kffpderfgd
      721 esplltmrqp grcrvnstpp aetmftdlds fvafhpplpp ppppyhppat pihnqlkagw
      781 kqrppsqhps rsfsypcnhs lfhsrtapka gpppvylpsv kaappdctst aglgrqtvaa
      841 aaatttstat aaaaaasekq vrtqpvlndl mpdiavgvst lslkdrrlpe lavdtelsqs
      901 vseagpgppq hlscipqrht htsrkkhtle qktdtrenpq eypdfydfsn aacrpstpal
      961 srrtpspsqg gyfgpdlysh nkaspsglks aylpgqtspk kqeearreyp lspdghlhrq
     1021 knepihldvv eqppqrsdfp laapenastg pahvrgrtav etdltfgltp nrpslsacss
     1081 eapeersgrr ladseslghg aqrntdlere dsisrgrrsp skpdflykks al
//
LOCUS       XP_047287522            1132 aa            linear   PRI 05-AUG-2025
DEFINITION  BTB/POZ domain-containing protein 7 isoform X1 [Homo sapiens].
ACCESSION   XP_047287522
VERSION     XP_047287522.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431566.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1132
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1132
                     /product="BTB/POZ domain-containing protein 7 isoform X1"
                     /calculated_mol_wt=126238
     Region          140..231
                     /region_name="BTB1_POZ_BTBD7"
                     /note="first BTB (Broad-Complex, Tramtrack and Bric a
                     brac)/POZ (poxvirus and zinc finger) domain found in
                     BTB/POZ domain-containing protein 7 (BTBD7); cd18283"
                     /db_xref="CDD:349592"
     Region          245..392
                     /region_name="BTB2_POZ_BTBD7"
                     /note="second BTB (Broad-Complex, Tramtrack and Bric a
                     brac)/POZ (poxvirus and zinc finger) domain found in
                     BTB/POZ domain-containing protein 7 (BTBD7); cd18284"
                     /db_xref="CDD:349593"
     Region          397..494
                     /region_name="BACK_BTBD7"
                     /note="BACK (BTB and C-terminal Kelch) domain found in
                     BTB/POZ domain-containing protein 7 (BTBD7); cd18489"
                     /db_xref="CDD:350564"
     CDS             1..1132
                     /gene="BTBD7"
                     /gene_synonym="FUP1"
                     /coded_by="XM_047431566.1:13376..16774"
                     /db_xref="GeneID:55727"
                     /db_xref="HGNC:HGNC:18269"
                     /db_xref="MIM:610386"
ORIGIN      
        1 mganasnyph scsprvggns qaqqtfigts sysqqgygce sklysldhgh ekpqdkkkrt
       61 sglatlkkkf ikrrksnrsa dhakqmrell sgwdvrdvna lveeyegtsa lkelslqasl
      121 arpeartlqk dmadlyeyky ctdvdlifqe tcfpvhrail aarcpffktl lssspeygae
      181 iimdintagi dmpmfsallh ylytgefgme dsrfqnvdil vqlseefgtp nsldvdmrgl
      241 fdymcyydvv lsfssdselv eafggnqncl deelkahkav isarspffrn llqrrirtge
      301 eitdrtlrtp triildesii pkkyatvilh cmytdvvdls vlhcspsvgs lsevqalvag
      361 kpnmtraeea melyhialfl efnmlaqgce diiaesisld tliailkwss hpygskwvhr
      421 qalhflceef sqvmtsdvfy elskdhllta iqsdylqase qdilkylikw gehqlmkria
      481 drepnllsgt ahsvnkrgvk rrdldmeelr eilssllpfv riehilpins evlsdamkrg
      541 listppsdml ptteggksna wlrqknagiy vrprlfspyv eeaksvldem mveqtdlvrl
      601 rmvrmsnvpd tlymvnnavp qcchmishqq issnqsspps vvaneipvpr llimkdmvrr
      661 lqelrhteqv qrayalncge gatvsyeiqi rvlrefglad aaaellqnph kffpderfgd
      721 esplltmrqp grcrvnstpp aetmftdlds fvafhpplpp ppppyhppat pihnqlkagw
      781 kqrppsqhps rsfsypcnhs lfhsrtapka gpppvylpsv kaappdctst aglgrqtvaa
      841 aaatttstat aaaaaasekq vrtqpvlndl mpdiavgvst lslkdrrlpe lavdtelsqs
      901 vseagpgppq hlscipqrht htsrkkhtle qktdtrenpq eypdfydfsn aacrpstpal
      961 srrtpspsqg gyfgpdlysh nkaspsglks aylpgqtspk kqeearreyp lspdghlhrq
     1021 knepihldvv eqppqrsdfp laapenastg pahvrgrtav etdltfgltp nrpslsacss
     1081 eapeersgrr ladseslghg aqrntdlere dsisrgrrsp skpdflykks al
//
LOCUS       XP_011535241            1132 aa            linear   PRI 05-AUG-2025
DEFINITION  BTB/POZ domain-containing protein 7 isoform X1 [Homo sapiens].
ACCESSION   XP_011535241
VERSION     XP_011535241.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536939.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1132
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1132
                     /product="BTB/POZ domain-containing protein 7 isoform X1"
                     /calculated_mol_wt=126238
     Region          140..231
                     /region_name="BTB1_POZ_BTBD7"
                     /note="first BTB (Broad-Complex, Tramtrack and Bric a
                     brac)/POZ (poxvirus and zinc finger) domain found in
                     BTB/POZ domain-containing protein 7 (BTBD7); cd18283"
                     /db_xref="CDD:349592"
     Region          245..392
                     /region_name="BTB2_POZ_BTBD7"
                     /note="second BTB (Broad-Complex, Tramtrack and Bric a
                     brac)/POZ (poxvirus and zinc finger) domain found in
                     BTB/POZ domain-containing protein 7 (BTBD7); cd18284"
                     /db_xref="CDD:349593"
     Region          397..494
                     /region_name="BACK_BTBD7"
                     /note="BACK (BTB and C-terminal Kelch) domain found in
                     BTB/POZ domain-containing protein 7 (BTBD7); cd18489"
                     /db_xref="CDD:350564"
     CDS             1..1132
                     /gene="BTBD7"
                     /gene_synonym="FUP1"
                     /coded_by="XM_011536939.3:388..3786"
                     /db_xref="GeneID:55727"
                     /db_xref="HGNC:HGNC:18269"
                     /db_xref="MIM:610386"
ORIGIN      
        1 mganasnyph scsprvggns qaqqtfigts sysqqgygce sklysldhgh ekpqdkkkrt
       61 sglatlkkkf ikrrksnrsa dhakqmrell sgwdvrdvna lveeyegtsa lkelslqasl
      121 arpeartlqk dmadlyeyky ctdvdlifqe tcfpvhrail aarcpffktl lssspeygae
      181 iimdintagi dmpmfsallh ylytgefgme dsrfqnvdil vqlseefgtp nsldvdmrgl
      241 fdymcyydvv lsfssdselv eafggnqncl deelkahkav isarspffrn llqrrirtge
      301 eitdrtlrtp triildesii pkkyatvilh cmytdvvdls vlhcspsvgs lsevqalvag
      361 kpnmtraeea melyhialfl efnmlaqgce diiaesisld tliailkwss hpygskwvhr
      421 qalhflceef sqvmtsdvfy elskdhllta iqsdylqase qdilkylikw gehqlmkria
      481 drepnllsgt ahsvnkrgvk rrdldmeelr eilssllpfv riehilpins evlsdamkrg
      541 listppsdml ptteggksna wlrqknagiy vrprlfspyv eeaksvldem mveqtdlvrl
      601 rmvrmsnvpd tlymvnnavp qcchmishqq issnqsspps vvaneipvpr llimkdmvrr
      661 lqelrhteqv qrayalncge gatvsyeiqi rvlrefglad aaaellqnph kffpderfgd
      721 esplltmrqp grcrvnstpp aetmftdlds fvafhpplpp ppppyhppat pihnqlkagw
      781 kqrppsqhps rsfsypcnhs lfhsrtapka gpppvylpsv kaappdctst aglgrqtvaa
      841 aaatttstat aaaaaasekq vrtqpvlndl mpdiavgvst lslkdrrlpe lavdtelsqs
      901 vseagpgppq hlscipqrht htsrkkhtle qktdtrenpq eypdfydfsn aacrpstpal
      961 srrtpspsqg gyfgpdlysh nkaspsglks aylpgqtspk kqeearreyp lspdghlhrq
     1021 knepihldvv eqppqrsdfp laapenastg pahvrgrtav etdltfgltp nrpslsacss
     1081 eapeersgrr ladseslghg aqrntdlere dsisrgrrsp skpdflykks al
//
LOCUS       XP_016876927             657 aa            linear   PRI 05-AUG-2025
DEFINITION  BTB/POZ domain-containing protein 7 isoform X2 [Homo sapiens].
ACCESSION   XP_016876927
VERSION     XP_016876927.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021438.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..657
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..657
                     /product="BTB/POZ domain-containing protein 7 isoform X2"
                     /calculated_mol_wt=72432
     Region          <1..19
                     /region_name="BACK"
                     /note="BACK (BTB and C-terminal Kelch) domain; cl28903"
                     /db_xref="CDD:475122"
     CDS             1..657
                     /gene="BTBD7"
                     /gene_synonym="FUP1"
                     /coded_by="XM_017021438.2:132..2105"
                     /db_xref="GeneID:55727"
                     /db_xref="HGNC:HGNC:18269"
                     /db_xref="MIM:610386"
ORIGIN      
        1 mkriadrepn llsgtahsvn krgvkrrdld meelreilss llpfvriehi lpinsevlsd
       61 amkrglistp psdmlptteg gksnawlrqk nagiyvrprl fspyveeaks vldemmveqt
      121 dlvrlrmvrm snvpdtlymv nnavpqcchm ishqqissnq ssppsvvane ipvprllimk
      181 dmvrrlqelr hteqvqraya lncgegatvs yeiqirvlre fgladaaael lqnphkffpd
      241 erfgdespll tmrqpgrcrv nstppaetmf tdldsfvafh pplppppppy hppatpihnq
      301 lkagwkqrpp sqhpsrsfsy pcnhslfhsr tapkagpppv ylpsvkaapp dctstaglgr
      361 qtvaaaaatt tstataaaaa asekqvrtqp vlndlmpdia vgvstlslkd rrlpelavdt
      421 elsqsvseag pgppqhlsci pqrhthtsrk khtleqktdt renpqeypdf ydfsnaacrp
      481 stpalsrrtp spsqggyfgp dlyshnkasp sglksaylpg qtspkkqeea rreyplspdg
      541 hlhrqknepi hldvveqppq rsdfplaape nastgpahvr grtavetdlt fgltpnrpsl
      601 sacsseapee rsgrrladse slghgaqrnt dleredsisr grrspskpdf lykksal
//
LOCUS       XP_047287523             410 aa            linear   PRI 05-AUG-2025
DEFINITION  BTB/POZ domain-containing protein 7 isoform X3 [Homo sapiens].
ACCESSION   XP_047287523
VERSION     XP_047287523.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431567.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..410
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..410
                     /product="BTB/POZ domain-containing protein 7 isoform X3"
                     /calculated_mol_wt=45912
     Region          140..231
                     /region_name="BTB1_POZ_BTBD7"
                     /note="first BTB (Broad-Complex, Tramtrack and Bric a
                     brac)/POZ (poxvirus and zinc finger) domain found in
                     BTB/POZ domain-containing protein 7 (BTBD7); cd18283"
                     /db_xref="CDD:349592"
     Region          245..387
                     /region_name="BTB2_POZ_BTBD7"
                     /note="second BTB (Broad-Complex, Tramtrack and Bric a
                     brac)/POZ (poxvirus and zinc finger) domain found in
                     BTB/POZ domain-containing protein 7 (BTBD7); cd18284"
                     /db_xref="CDD:349593"
     CDS             1..410
                     /gene="BTBD7"
                     /gene_synonym="FUP1"
                     /coded_by="XM_047431567.1:24135..25367"
                     /db_xref="GeneID:55727"
                     /db_xref="HGNC:HGNC:18269"
                     /db_xref="MIM:610386"
ORIGIN      
        1 mganasnyph scsprvggns qaqqtfigts sysqqgygce sklysldhgh ekpqdkkkrt
       61 sglatlkkkf ikrrksnrsa dhakqmrell sgwdvrdvna lveeyegtsa lkelslqasl
      121 arpeartlqk dmadlyeyky ctdvdlifqe tcfpvhrail aarcpffktl lssspeygae
      181 iimdintagi dmpmfsallh ylytgefgme dsrfqnvdil vqlseefgtp nsldvdmrgl
      241 fdymcyydvv lsfssdselv eafggnqncl deelkahkav isarspffrn llqrrirtge
      301 eitdrtlrtp triildesii pkkyatvilh cmytdvvdls vlhcspsvgs lsevqalvag
      361 kpnmtraeea melyhialfl efnmlaqeet tvirpacaae lsnscllpqs
//
LOCUS       XP_011535242             504 aa            linear   PRI 05-AUG-2025
DEFINITION  AP-5 complex subunit mu-1 isoform X1 [Homo sapiens].
ACCESSION   XP_011535242
VERSION     XP_011535242.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536940.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..504
                     /product="AP-5 complex subunit mu-1 isoform X1"
                     /calculated_mol_wt=56335
     Region          210..496
                     /region_name="AP_MuD_MHD"
                     /note="Mu-homology domain (MHD) of a adaptor protein (AP)
                     encoded by mu-2 related death-inducing gene, MuD (also
                     known as MUDENG); cd09256"
                     /db_xref="CDD:271164"
     CDS             1..504
                     /gene="AP5M1"
                     /gene_synonym="C14orf108; Mu5; MuD; MUDENG"
                     /coded_by="XM_011536940.4:345..1859"
                     /db_xref="GeneID:55745"
                     /db_xref="HGNC:HGNC:20192"
                     /db_xref="MIM:614368"
ORIGIN      
        1 maqravwlis hepgtplcgt vrfsrdwqed sgylsftirr yptvekrarv fngasyvpvp
       61 edgpflkall felrlldddk dfvesrdscs rinktsiygl liggeelwpv vaflkndmiy
      121 acvplveqtl sprpplisvs gvsqgfeflf giqdflysgq kndselntkl sqlpdlllqa
      181 cpfgtlldan lqnsldntnf asvtqpqkqp awktgtykgk pqvsisitek vksmqydkqg
      241 iadtwqvvgt vtckcdlegi mpnvtislsl ptngsplqdi lvhpcvtsld sailtsssid
      301 amddsafsgp ykfpftpple sfnlcfytsq vpvppilgfy qmkeeevqlr itinlklhes
      361 vknnfefcea hipfynrgpi thleyktsfg qlevfreksl liwiigqkfp ksmeislsgt
      421 vtfgakshek qpfdpictge taylklhfri ldytltgcya dqhsvqvfas gkpkisahrk
      481 lissdyyiwn skapapvtyg slll
//
LOCUS       XP_047287524             608 aa            linear   PRI 05-AUG-2025
DEFINITION  tyrosyl-DNA phosphodiesterase 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047287524
VERSION     XP_047287524.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431568.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..608
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..608
                     /product="tyrosyl-DNA phosphodiesterase 1 isoform X1"
                     /calculated_mol_wt=68290
     Region          166..582
                     /region_name="Tyr-DNA_phospho"
                     /note="Tyrosyl-DNA phosphodiesterase; pfam06087"
                     /db_xref="CDD:461824"
     CDS             1..608
                     /gene="TDP1"
                     /coded_by="XM_047431568.1:882..2708"
                     /db_xref="GeneID:55775"
                     /db_xref="HGNC:HGNC:18884"
                     /db_xref="MIM:607198"
ORIGIN      
        1 msqegdygrw tisssdesee ekpkpdkpst ssllcarqga aneprytcse aqkaahkrki
       61 spvkfsntds vlppkrqksg sqedlgwcls ssddelqpem pqkqaekvvi kkekdisapn
      121 dgtaqrtenh gapachrlke eedeyetsge gqdiwdmldk gnpfqfyltr vsgvkpkyns
      181 galhikdils plfgtlvssa qfnycfdvdw lvkqyppefr kkpillvhgd kreakahlha
      241 qakpyenisl cqakldiafg thhtkmmlll yeeglrvvih tsnlihadwh qktqgiwlsp
      301 lypriadgth ksgespthfk adlisylmay napslkewid vihkhdlset nvyligstpg
      361 rfqgsqkdnw ghfrlkkllk dhassmpnae swpvvgqfss vgslgadesk wlcsefkesm
      421 ltlgkesktp gkssvplyli ypsvenvrts legypaggsl pysiqtaekq nwlhsyfhkw
      481 saetsgrsna mphiktymrp spdfskiawf lvtsanlska awgalekngt qlmirsyelg
      541 vlflpsafgl dsfkvkqkff agsqepmatf pvpydlppel ygskdrpwiw nipyvkapdt
      601 hgnmwvps
//
LOCUS       XP_005267905             608 aa            linear   PRI 05-AUG-2025
DEFINITION  tyrosyl-DNA phosphodiesterase 1 isoform X1 [Homo sapiens].
ACCESSION   XP_005267905
VERSION     XP_005267905.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267848.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..608
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..608
                     /product="tyrosyl-DNA phosphodiesterase 1 isoform X1"
                     /calculated_mol_wt=68290
     Region          166..582
                     /region_name="Tyr-DNA_phospho"
                     /note="Tyrosyl-DNA phosphodiesterase; pfam06087"
                     /db_xref="CDD:461824"
     CDS             1..608
                     /gene="TDP1"
                     /coded_by="XM_005267848.4:360..2186"
                     /db_xref="GeneID:55775"
                     /db_xref="HGNC:HGNC:18884"
                     /db_xref="MIM:607198"
ORIGIN      
        1 msqegdygrw tisssdesee ekpkpdkpst ssllcarqga aneprytcse aqkaahkrki
       61 spvkfsntds vlppkrqksg sqedlgwcls ssddelqpem pqkqaekvvi kkekdisapn
      121 dgtaqrtenh gapachrlke eedeyetsge gqdiwdmldk gnpfqfyltr vsgvkpkyns
      181 galhikdils plfgtlvssa qfnycfdvdw lvkqyppefr kkpillvhgd kreakahlha
      241 qakpyenisl cqakldiafg thhtkmmlll yeeglrvvih tsnlihadwh qktqgiwlsp
      301 lypriadgth ksgespthfk adlisylmay napslkewid vihkhdlset nvyligstpg
      361 rfqgsqkdnw ghfrlkkllk dhassmpnae swpvvgqfss vgslgadesk wlcsefkesm
      421 ltlgkesktp gkssvplyli ypsvenvrts legypaggsl pysiqtaekq nwlhsyfhkw
      481 saetsgrsna mphiktymrp spdfskiawf lvtsanlska awgalekngt qlmirsyelg
      541 vlflpsafgl dsfkvkqkff agsqepmatf pvpydlppel ygskdrpwiw nipyvkapdt
      601 hgnmwvps
//
LOCUS       XP_006720260             608 aa            linear   PRI 05-AUG-2025
DEFINITION  tyrosyl-DNA phosphodiesterase 1 isoform X1 [Homo sapiens].
ACCESSION   XP_006720260
VERSION     XP_006720260.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720197.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..608
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..608
                     /product="tyrosyl-DNA phosphodiesterase 1 isoform X1"
                     /calculated_mol_wt=68290
     Region          166..582
                     /region_name="Tyr-DNA_phospho"
                     /note="Tyrosyl-DNA phosphodiesterase; pfam06087"
                     /db_xref="CDD:461824"
     CDS             1..608
                     /gene="TDP1"
                     /coded_by="XM_006720197.5:583..2409"
                     /db_xref="GeneID:55775"
                     /db_xref="HGNC:HGNC:18884"
                     /db_xref="MIM:607198"
ORIGIN      
        1 msqegdygrw tisssdesee ekpkpdkpst ssllcarqga aneprytcse aqkaahkrki
       61 spvkfsntds vlppkrqksg sqedlgwcls ssddelqpem pqkqaekvvi kkekdisapn
      121 dgtaqrtenh gapachrlke eedeyetsge gqdiwdmldk gnpfqfyltr vsgvkpkyns
      181 galhikdils plfgtlvssa qfnycfdvdw lvkqyppefr kkpillvhgd kreakahlha
      241 qakpyenisl cqakldiafg thhtkmmlll yeeglrvvih tsnlihadwh qktqgiwlsp
      301 lypriadgth ksgespthfk adlisylmay napslkewid vihkhdlset nvyligstpg
      361 rfqgsqkdnw ghfrlkkllk dhassmpnae swpvvgqfss vgslgadesk wlcsefkesm
      421 ltlgkesktp gkssvplyli ypsvenvrts legypaggsl pysiqtaekq nwlhsyfhkw
      481 saetsgrsna mphiktymrp spdfskiawf lvtsanlska awgalekngt qlmirsyelg
      541 vlflpsafgl dsfkvkqkff agsqepmatf pvpydlppel ygskdrpwiw nipyvkapdt
      601 hgnmwvps
//
LOCUS       XP_047287525             608 aa            linear   PRI 05-AUG-2025
DEFINITION  tyrosyl-DNA phosphodiesterase 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047287525
VERSION     XP_047287525.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431569.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..608
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..608
                     /product="tyrosyl-DNA phosphodiesterase 1 isoform X1"
                     /calculated_mol_wt=68290
     Region          166..582
                     /region_name="Tyr-DNA_phospho"
                     /note="Tyrosyl-DNA phosphodiesterase; pfam06087"
                     /db_xref="CDD:461824"
     CDS             1..608
                     /gene="TDP1"
                     /coded_by="XM_047431569.1:766..2592"
                     /db_xref="GeneID:55775"
                     /db_xref="HGNC:HGNC:18884"
                     /db_xref="MIM:607198"
ORIGIN      
        1 msqegdygrw tisssdesee ekpkpdkpst ssllcarqga aneprytcse aqkaahkrki
       61 spvkfsntds vlppkrqksg sqedlgwcls ssddelqpem pqkqaekvvi kkekdisapn
      121 dgtaqrtenh gapachrlke eedeyetsge gqdiwdmldk gnpfqfyltr vsgvkpkyns
      181 galhikdils plfgtlvssa qfnycfdvdw lvkqyppefr kkpillvhgd kreakahlha
      241 qakpyenisl cqakldiafg thhtkmmlll yeeglrvvih tsnlihadwh qktqgiwlsp
      301 lypriadgth ksgespthfk adlisylmay napslkewid vihkhdlset nvyligstpg
      361 rfqgsqkdnw ghfrlkkllk dhassmpnae swpvvgqfss vgslgadesk wlcsefkesm
      421 ltlgkesktp gkssvplyli ypsvenvrts legypaggsl pysiqtaekq nwlhsyfhkw
      481 saetsgrsna mphiktymrp spdfskiawf lvtsanlska awgalekngt qlmirsyelg
      541 vlflpsafgl dsfkvkqkff agsqepmatf pvpydlppel ygskdrpwiw nipyvkapdt
      601 hgnmwvps
//
LOCUS       XP_047287526             608 aa            linear   PRI 05-AUG-2025
DEFINITION  tyrosyl-DNA phosphodiesterase 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047287526
VERSION     XP_047287526.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431570.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..608
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..608
                     /product="tyrosyl-DNA phosphodiesterase 1 isoform X1"
                     /calculated_mol_wt=68290
     Region          166..582
                     /region_name="Tyr-DNA_phospho"
                     /note="Tyrosyl-DNA phosphodiesterase; pfam06087"
                     /db_xref="CDD:461824"
     CDS             1..608
                     /gene="TDP1"
                     /coded_by="XM_047431570.1:941..2767"
                     /db_xref="GeneID:55775"
                     /db_xref="HGNC:HGNC:18884"
                     /db_xref="MIM:607198"
ORIGIN      
        1 msqegdygrw tisssdesee ekpkpdkpst ssllcarqga aneprytcse aqkaahkrki
       61 spvkfsntds vlppkrqksg sqedlgwcls ssddelqpem pqkqaekvvi kkekdisapn
      121 dgtaqrtenh gapachrlke eedeyetsge gqdiwdmldk gnpfqfyltr vsgvkpkyns
      181 galhikdils plfgtlvssa qfnycfdvdw lvkqyppefr kkpillvhgd kreakahlha
      241 qakpyenisl cqakldiafg thhtkmmlll yeeglrvvih tsnlihadwh qktqgiwlsp
      301 lypriadgth ksgespthfk adlisylmay napslkewid vihkhdlset nvyligstpg
      361 rfqgsqkdnw ghfrlkkllk dhassmpnae swpvvgqfss vgslgadesk wlcsefkesm
      421 ltlgkesktp gkssvplyli ypsvenvrts legypaggsl pysiqtaekq nwlhsyfhkw
      481 saetsgrsna mphiktymrp spdfskiawf lvtsanlska awgalekngt qlmirsyelg
      541 vlflpsafgl dsfkvkqkff agsqepmatf pvpydlppel ygskdrpwiw nipyvkapdt
      601 hgnmwvps
//
LOCUS       XP_047287528             608 aa            linear   PRI 05-AUG-2025
DEFINITION  tyrosyl-DNA phosphodiesterase 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047287528
VERSION     XP_047287528.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431572.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..608
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..608
                     /product="tyrosyl-DNA phosphodiesterase 1 isoform X1"
                     /calculated_mol_wt=68290
     Region          166..582
                     /region_name="Tyr-DNA_phospho"
                     /note="Tyrosyl-DNA phosphodiesterase; pfam06087"
                     /db_xref="CDD:461824"
     CDS             1..608
                     /gene="TDP1"
                     /coded_by="XM_047431572.1:364..2190"
                     /db_xref="GeneID:55775"
                     /db_xref="HGNC:HGNC:18884"
                     /db_xref="MIM:607198"
ORIGIN      
        1 msqegdygrw tisssdesee ekpkpdkpst ssllcarqga aneprytcse aqkaahkrki
       61 spvkfsntds vlppkrqksg sqedlgwcls ssddelqpem pqkqaekvvi kkekdisapn
      121 dgtaqrtenh gapachrlke eedeyetsge gqdiwdmldk gnpfqfyltr vsgvkpkyns
      181 galhikdils plfgtlvssa qfnycfdvdw lvkqyppefr kkpillvhgd kreakahlha
      241 qakpyenisl cqakldiafg thhtkmmlll yeeglrvvih tsnlihadwh qktqgiwlsp
      301 lypriadgth ksgespthfk adlisylmay napslkewid vihkhdlset nvyligstpg
      361 rfqgsqkdnw ghfrlkkllk dhassmpnae swpvvgqfss vgslgadesk wlcsefkesm
      421 ltlgkesktp gkssvplyli ypsvenvrts legypaggsl pysiqtaekq nwlhsyfhkw
      481 saetsgrsna mphiktymrp spdfskiawf lvtsanlska awgalekngt qlmirsyelg
      541 vlflpsafgl dsfkvkqkff agsqepmatf pvpydlppel ygskdrpwiw nipyvkapdt
      601 hgnmwvps
//
LOCUS       XP_011535244             608 aa            linear   PRI 05-AUG-2025
DEFINITION  tyrosyl-DNA phosphodiesterase 1 isoform X1 [Homo sapiens].
ACCESSION   XP_011535244
VERSION     XP_011535244.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536942.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..608
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..608
                     /product="tyrosyl-DNA phosphodiesterase 1 isoform X1"
                     /calculated_mol_wt=68290
     Region          166..582
                     /region_name="Tyr-DNA_phospho"
                     /note="Tyrosyl-DNA phosphodiesterase; pfam06087"
                     /db_xref="CDD:461824"
     CDS             1..608
                     /gene="TDP1"
                     /coded_by="XM_011536942.4:718..2544"
                     /db_xref="GeneID:55775"
                     /db_xref="HGNC:HGNC:18884"
                     /db_xref="MIM:607198"
ORIGIN      
        1 msqegdygrw tisssdesee ekpkpdkpst ssllcarqga aneprytcse aqkaahkrki
       61 spvkfsntds vlppkrqksg sqedlgwcls ssddelqpem pqkqaekvvi kkekdisapn
      121 dgtaqrtenh gapachrlke eedeyetsge gqdiwdmldk gnpfqfyltr vsgvkpkyns
      181 galhikdils plfgtlvssa qfnycfdvdw lvkqyppefr kkpillvhgd kreakahlha
      241 qakpyenisl cqakldiafg thhtkmmlll yeeglrvvih tsnlihadwh qktqgiwlsp
      301 lypriadgth ksgespthfk adlisylmay napslkewid vihkhdlset nvyligstpg
      361 rfqgsqkdnw ghfrlkkllk dhassmpnae swpvvgqfss vgslgadesk wlcsefkesm
      421 ltlgkesktp gkssvplyli ypsvenvrts legypaggsl pysiqtaekq nwlhsyfhkw
      481 saetsgrsna mphiktymrp spdfskiawf lvtsanlska awgalekngt qlmirsyelg
      541 vlflpsafgl dsfkvkqkff agsqepmatf pvpydlppel ygskdrpwiw nipyvkapdt
      601 hgnmwvps
//
LOCUS       XP_047287529             608 aa            linear   PRI 05-AUG-2025
DEFINITION  tyrosyl-DNA phosphodiesterase 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047287529
VERSION     XP_047287529.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431573.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..608
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..608
                     /product="tyrosyl-DNA phosphodiesterase 1 isoform X1"
                     /calculated_mol_wt=68290
     Region          166..582
                     /region_name="Tyr-DNA_phospho"
                     /note="Tyrosyl-DNA phosphodiesterase; pfam06087"
                     /db_xref="CDD:461824"
     CDS             1..608
                     /gene="TDP1"
                     /coded_by="XM_047431573.1:467..2293"
                     /db_xref="GeneID:55775"
                     /db_xref="HGNC:HGNC:18884"
                     /db_xref="MIM:607198"
ORIGIN      
        1 msqegdygrw tisssdesee ekpkpdkpst ssllcarqga aneprytcse aqkaahkrki
       61 spvkfsntds vlppkrqksg sqedlgwcls ssddelqpem pqkqaekvvi kkekdisapn
      121 dgtaqrtenh gapachrlke eedeyetsge gqdiwdmldk gnpfqfyltr vsgvkpkyns
      181 galhikdils plfgtlvssa qfnycfdvdw lvkqyppefr kkpillvhgd kreakahlha
      241 qakpyenisl cqakldiafg thhtkmmlll yeeglrvvih tsnlihadwh qktqgiwlsp
      301 lypriadgth ksgespthfk adlisylmay napslkewid vihkhdlset nvyligstpg
      361 rfqgsqkdnw ghfrlkkllk dhassmpnae swpvvgqfss vgslgadesk wlcsefkesm
      421 ltlgkesktp gkssvplyli ypsvenvrts legypaggsl pysiqtaekq nwlhsyfhkw
      481 saetsgrsna mphiktymrp spdfskiawf lvtsanlska awgalekngt qlmirsyelg
      541 vlflpsafgl dsfkvkqkff agsqepmatf pvpydlppel ygskdrpwiw nipyvkapdt
      601 hgnmwvps
//
LOCUS       XP_047287530             608 aa            linear   PRI 05-AUG-2025
DEFINITION  tyrosyl-DNA phosphodiesterase 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047287530
VERSION     XP_047287530.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431574.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..608
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..608
                     /product="tyrosyl-DNA phosphodiesterase 1 isoform X1"
                     /calculated_mol_wt=68290
     Region          166..582
                     /region_name="Tyr-DNA_phospho"
                     /note="Tyrosyl-DNA phosphodiesterase; pfam06087"
                     /db_xref="CDD:461824"
     CDS             1..608
                     /gene="TDP1"
                     /coded_by="XM_047431574.1:1633..3459"
                     /db_xref="GeneID:55775"
                     /db_xref="HGNC:HGNC:18884"
                     /db_xref="MIM:607198"
ORIGIN      
        1 msqegdygrw tisssdesee ekpkpdkpst ssllcarqga aneprytcse aqkaahkrki
       61 spvkfsntds vlppkrqksg sqedlgwcls ssddelqpem pqkqaekvvi kkekdisapn
      121 dgtaqrtenh gapachrlke eedeyetsge gqdiwdmldk gnpfqfyltr vsgvkpkyns
      181 galhikdils plfgtlvssa qfnycfdvdw lvkqyppefr kkpillvhgd kreakahlha
      241 qakpyenisl cqakldiafg thhtkmmlll yeeglrvvih tsnlihadwh qktqgiwlsp
      301 lypriadgth ksgespthfk adlisylmay napslkewid vihkhdlset nvyligstpg
      361 rfqgsqkdnw ghfrlkkllk dhassmpnae swpvvgqfss vgslgadesk wlcsefkesm
      421 ltlgkesktp gkssvplyli ypsvenvrts legypaggsl pysiqtaekq nwlhsyfhkw
      481 saetsgrsna mphiktymrp spdfskiawf lvtsanlska awgalekngt qlmirsyelg
      541 vlflpsafgl dsfkvkqkff agsqepmatf pvpydlppel ygskdrpwiw nipyvkapdt
      601 hgnmwvps
//
LOCUS       XP_047287531             608 aa            linear   PRI 05-AUG-2025
DEFINITION  tyrosyl-DNA phosphodiesterase 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047287531
VERSION     XP_047287531.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431575.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..608
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..608
                     /product="tyrosyl-DNA phosphodiesterase 1 isoform X1"
                     /calculated_mol_wt=68290
     Region          166..582
                     /region_name="Tyr-DNA_phospho"
                     /note="Tyrosyl-DNA phosphodiesterase; pfam06087"
                     /db_xref="CDD:461824"
     CDS             1..608
                     /gene="TDP1"
                     /coded_by="XM_047431575.1:236..2062"
                     /db_xref="GeneID:55775"
                     /db_xref="HGNC:HGNC:18884"
                     /db_xref="MIM:607198"
ORIGIN      
        1 msqegdygrw tisssdesee ekpkpdkpst ssllcarqga aneprytcse aqkaahkrki
       61 spvkfsntds vlppkrqksg sqedlgwcls ssddelqpem pqkqaekvvi kkekdisapn
      121 dgtaqrtenh gapachrlke eedeyetsge gqdiwdmldk gnpfqfyltr vsgvkpkyns
      181 galhikdils plfgtlvssa qfnycfdvdw lvkqyppefr kkpillvhgd kreakahlha
      241 qakpyenisl cqakldiafg thhtkmmlll yeeglrvvih tsnlihadwh qktqgiwlsp
      301 lypriadgth ksgespthfk adlisylmay napslkewid vihkhdlset nvyligstpg
      361 rfqgsqkdnw ghfrlkkllk dhassmpnae swpvvgqfss vgslgadesk wlcsefkesm
      421 ltlgkesktp gkssvplyli ypsvenvrts legypaggsl pysiqtaekq nwlhsyfhkw
      481 saetsgrsna mphiktymrp spdfskiawf lvtsanlska awgalekngt qlmirsyelg
      541 vlflpsafgl dsfkvkqkff agsqepmatf pvpydlppel ygskdrpwiw nipyvkapdt
      601 hgnmwvps
//
LOCUS       XP_016876929             578 aa            linear   PRI 05-AUG-2025
DEFINITION  tyrosyl-DNA phosphodiesterase 1 isoform X2 [Homo sapiens].
ACCESSION   XP_016876929
VERSION     XP_016876929.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021440.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..578
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..578
                     /product="tyrosyl-DNA phosphodiesterase 1 isoform X2"
                     /calculated_mol_wt=64697
     Region          166..550
                     /region_name="Tyr-DNA_phospho"
                     /note="Tyrosyl-DNA phosphodiesterase; pfam06087"
                     /db_xref="CDD:461824"
     CDS             1..578
                     /gene="TDP1"
                     /coded_by="XM_017021440.3:52..1788"
                     /db_xref="GeneID:55775"
                     /db_xref="HGNC:HGNC:18884"
                     /db_xref="MIM:607198"
ORIGIN      
        1 msqegdygrw tisssdesee ekpkpdkpst ssllcarqga aneprytcse aqkaahkrki
       61 spvkfsntds vlppkrqksg sqedlgwcls ssddelqpem pqkqaekvvi kkekdisapn
      121 dgtaqrtenh gapachrlke eedeyetsge gqdiwdmldk gnpfqfyltr vsgvkpkyns
      181 galhikdils plfgtlvssa qfnycfdvdw lvkqyppefr kkpillvhgd kreakahlha
      241 qakpyenisl cqakldiafg thhtkmmlll yeeglrvvih tsnlihadwh qktqgiwlsp
      301 lypriadgth ksgespthfk adlisylmay napslkewid vihkhdlset nvyligstpg
      361 rfqgsqkdnw ghfrlkkllk dhassmpnae swpvvgqfss vgslgadesk wlcsefkesm
      421 ltlgkesktp gkssvplyli ypsvenvrts legypaggsl pysiqtaekq nwlhsyfhkw
      481 saetsgrsna mphiktymrp spdfskiawf lvtsanlska awgalekngt qlmirsyelg
      541 vlflpsafig hgygtflmsk hrirmgtcgc ppenleal
//
LOCUS       XP_047287532             578 aa            linear   PRI 05-AUG-2025
DEFINITION  tyrosyl-DNA phosphodiesterase 1 isoform X2 [Homo sapiens].
ACCESSION   XP_047287532
VERSION     XP_047287532.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431576.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..578
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..578
                     /product="tyrosyl-DNA phosphodiesterase 1 isoform X2"
                     /calculated_mol_wt=64697
     Region          166..550
                     /region_name="Tyr-DNA_phospho"
                     /note="Tyrosyl-DNA phosphodiesterase; pfam06087"
                     /db_xref="CDD:461824"
     CDS             1..578
                     /gene="TDP1"
                     /coded_by="XM_047431576.1:882..2618"
                     /db_xref="GeneID:55775"
                     /db_xref="HGNC:HGNC:18884"
                     /db_xref="MIM:607198"
ORIGIN      
        1 msqegdygrw tisssdesee ekpkpdkpst ssllcarqga aneprytcse aqkaahkrki
       61 spvkfsntds vlppkrqksg sqedlgwcls ssddelqpem pqkqaekvvi kkekdisapn
      121 dgtaqrtenh gapachrlke eedeyetsge gqdiwdmldk gnpfqfyltr vsgvkpkyns
      181 galhikdils plfgtlvssa qfnycfdvdw lvkqyppefr kkpillvhgd kreakahlha
      241 qakpyenisl cqakldiafg thhtkmmlll yeeglrvvih tsnlihadwh qktqgiwlsp
      301 lypriadgth ksgespthfk adlisylmay napslkewid vihkhdlset nvyligstpg
      361 rfqgsqkdnw ghfrlkkllk dhassmpnae swpvvgqfss vgslgadesk wlcsefkesm
      421 ltlgkesktp gkssvplyli ypsvenvrts legypaggsl pysiqtaekq nwlhsyfhkw
      481 saetsgrsna mphiktymrp spdfskiawf lvtsanlska awgalekngt qlmirsyelg
      541 vlflpsafig hgygtflmsk hrirmgtcgc ppenleal
//
LOCUS       XP_047287533             578 aa            linear   PRI 05-AUG-2025
DEFINITION  tyrosyl-DNA phosphodiesterase 1 isoform X2 [Homo sapiens].
ACCESSION   XP_047287533
VERSION     XP_047287533.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431577.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..578
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..578
                     /product="tyrosyl-DNA phosphodiesterase 1 isoform X2"
                     /calculated_mol_wt=64697
     Region          166..550
                     /region_name="Tyr-DNA_phospho"
                     /note="Tyrosyl-DNA phosphodiesterase; pfam06087"
                     /db_xref="CDD:461824"
     CDS             1..578
                     /gene="TDP1"
                     /coded_by="XM_047431577.1:583..2319"
                     /db_xref="GeneID:55775"
                     /db_xref="HGNC:HGNC:18884"
                     /db_xref="MIM:607198"
ORIGIN      
        1 msqegdygrw tisssdesee ekpkpdkpst ssllcarqga aneprytcse aqkaahkrki
       61 spvkfsntds vlppkrqksg sqedlgwcls ssddelqpem pqkqaekvvi kkekdisapn
      121 dgtaqrtenh gapachrlke eedeyetsge gqdiwdmldk gnpfqfyltr vsgvkpkyns
      181 galhikdils plfgtlvssa qfnycfdvdw lvkqyppefr kkpillvhgd kreakahlha
      241 qakpyenisl cqakldiafg thhtkmmlll yeeglrvvih tsnlihadwh qktqgiwlsp
      301 lypriadgth ksgespthfk adlisylmay napslkewid vihkhdlset nvyligstpg
      361 rfqgsqkdnw ghfrlkkllk dhassmpnae swpvvgqfss vgslgadesk wlcsefkesm
      421 ltlgkesktp gkssvplyli ypsvenvrts legypaggsl pysiqtaekq nwlhsyfhkw
      481 saetsgrsna mphiktymrp spdfskiawf lvtsanlska awgalekngt qlmirsyelg
      541 vlflpsafig hgygtflmsk hrirmgtcgc ppenleal
//
LOCUS       XP_047287534             369 aa            linear   PRI 05-AUG-2025
DEFINITION  tyrosyl-DNA phosphodiesterase 1 isoform X3 [Homo sapiens].
ACCESSION   XP_047287534
VERSION     XP_047287534.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431578.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..369
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..369
                     /product="tyrosyl-DNA phosphodiesterase 1 isoform X3"
                     /calculated_mol_wt=41499
     Region          <26..343
                     /region_name="Tyr-DNA_phospho"
                     /note="Tyrosyl-DNA phosphodiesterase; pfam06087"
                     /db_xref="CDD:461824"
     CDS             1..369
                     /gene="TDP1"
                     /coded_by="XM_047431578.1:168..1277"
                     /db_xref="GeneID:55775"
                     /db_xref="HGNC:HGNC:18884"
                     /db_xref="MIM:607198"
ORIGIN      
        1 mviserlrlt smprpsltrt slsarkmmll lyeeglrvvi htsnlihadw hqktqgiwls
       61 plypriadgt hksgespthf kadlisylma ynapslkewi dvihkhdlse tnvyligstp
      121 grfqgsqkdn wghfrlkkll kdhassmpna eswpvvgqfs svgslgades kwlcsefkes
      181 mltlgkeskt pgkssvplyl iypsvenvrt slegypaggs lpysiqtaek qnwlhsyfhk
      241 wsaetsgrsn amphiktymr pspdfskiaw flvtsanlsk aawgalekng tqlmirsyel
      301 gvlflpsafg ldsfkvkqkf fagsqepmat fpvpydlppe lygskdrpwi wnipyvkapd
      361 thgnmwvps
//
LOCUS       XP_047287535             343 aa            linear   PRI 05-AUG-2025
DEFINITION  tyrosyl-DNA phosphodiesterase 1 isoform X4 [Homo sapiens].
ACCESSION   XP_047287535
VERSION     XP_047287535.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431579.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..343
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..343
                     /product="tyrosyl-DNA phosphodiesterase 1 isoform X4"
                     /calculated_mol_wt=38529
     Region          <1..317
                     /region_name="Tyr-DNA_phospho"
                     /note="Tyrosyl-DNA phosphodiesterase; pfam06087"
                     /db_xref="CDD:461824"
     CDS             1..343
                     /gene="TDP1"
                     /coded_by="XM_047431579.1:281..1312"
                     /db_xref="GeneID:55775"
                     /db_xref="HGNC:HGNC:18884"
                     /db_xref="MIM:607198"
ORIGIN      
        1 mmlllyeegl rvvihtsnli hadwhqktqg iwlsplypri adgthksges pthfkadlis
       61 ylmaynapsl kewidvihkh dlsetnvyli gstpgrfqgs qkdnwghfrl kkllkdhass
      121 mpnaeswpvv gqfssvgslg adeskwlcse fkesmltlgk esktpgkssv plyliypsve
      181 nvrtslegyp aggslpysiq taekqnwlhs yfhkwsaets grsnamphik tymrpspdfs
      241 kiawflvtsa nlskaawgal ekngtqlmir syelgvlflp safgldsfkv kqkffagsqe
      301 pmatfpvpyd lppelygskd rpwiwnipyv kapdthgnmw vps
//
LOCUS       XP_011535247             961 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 839 isoform X1 [Homo sapiens].
ACCESSION   XP_011535247
VERSION     XP_011535247.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536945.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..961
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..961
                     /product="zinc finger protein 839 isoform X1"
                     /calculated_mol_wt=102880
     Region          157..954
                     /region_name="DUF4764"
                     /note="Domain of unknown function (DUF4764); pfam15961"
                     /db_xref="CDD:464955"
     CDS             1..961
                     /gene="ZNF839"
                     /gene_synonym="C14orf131"
                     /coded_by="XM_011536945.2:21..2906"
                     /db_xref="GeneID:55778"
                     /db_xref="HGNC:HGNC:20345"
ORIGIN      
        1 madaepeagg gsedgggggg pappgqsgsv arvaplgpeq lrqvleqvtk aqpppppppf
       61 vlrdaarrlr daaqqaalqr grgtepprlp rllppqgsls afriisgafe radlgaspqe
      121 irfsrsagte qleaicvkvt sgetkgqerp mllpttiqpq tarksqlprg nsclvglhia
      181 spqllrvqpl vrtepqscfl sdlcqppaqg fvqrplpalq vvpakrvpap kapdeqgsml
      241 tplsasdpla vtslssssah pfisnlhtrh teklkkslkv ktrsgrvsrp pkykakdykf
      301 iktedladgh lsdsddysel cveededqre rhalfdlssc slrpksfkcq tceksyigkg
      361 glarhfklnp ghgqldpemv lsekasgstl rgcteertls ltslglsmpa dpceggarsc
      421 lvtesarggl qngqsvdvee tlpsepenga llrseryqgp rrracsetla esrtavlqqr
      481 raaqlpggpa aageqrasps karlkeflqq cdredlvela lpqlaqvvtv yefllmkvek
      541 dhlakpffpa iykefeelhk mvkkmcqdyl sssglcsqet leinndkvae slgiteflrk
      601 keihpdnlgp khlsrdmdge qlegassekr ereaaeegla svkrprreal sndtteslaa
      661 nsrgrekprp lhalaagfsp pvnvtvsprs eeshtttvsg gngsvfqagp qlqalanlea
      721 rrgsigaals srdvsglpvy aqsgeprrlt qaqvaafpge nalehssdqd twdslrspgf
      781 csplssggga eslppggpgh aeaghlgkvc dfhlnhqqps ptsvlpteva applekilsv
      841 dsvavdcayr tvpkpgpqpg phgslltegc lrslsgdlnr fpcgmevhsg qrelesvvav
      901 geamafeisn gshellsqgq kqifiqtsdg lilsppgtiv sqeedivtvt daegracgwa
      961 r
//
LOCUS       XP_011535248             911 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 839 isoform X2 [Homo sapiens].
ACCESSION   XP_011535248
VERSION     XP_011535248.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536946.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..911
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..911
                     /product="zinc finger protein 839 isoform X2"
                     /calculated_mol_wt=97034
     Region          157..904
                     /region_name="DUF4764"
                     /note="Domain of unknown function (DUF4764); pfam15961"
                     /db_xref="CDD:464955"
     CDS             1..911
                     /gene="ZNF839"
                     /gene_synonym="C14orf131"
                     /coded_by="XM_011536946.4:21..2756"
                     /db_xref="GeneID:55778"
                     /db_xref="HGNC:HGNC:20345"
ORIGIN      
        1 madaepeagg gsedgggggg pappgqsgsv arvaplgpeq lrqvleqvtk aqpppppppf
       61 vlrdaarrlr daaqqaalqr grgtepprlp rllppqgsls afriisgafe radlgaspqe
      121 irfsrsagte qleaicvkvt sgetkgqerp mllpttiqpq tarksqlprg nsclvglhia
      181 spqllrvqpl vrtepqscfl sdlcqppaqg fvqrplpalq vvpakrvpap kapdeqgsml
      241 tplsasdpla vtslssssah pfisnlhtrh teklkkslkv ktrsgrvsrp pkykakdykf
      301 iktedladgh lsdsddysel cveededqre rhalfdlssc slrpksfkcq tceksyigkg
      361 glarhfklnp ghgqldpemv lsekasgstl rgcteertls ltslglsmpa dpceggarsc
      421 lvtesarggl qngqsvdvee tlpsepenga llrseryqgp rrracsetla esrtavlqqr
      481 raaqlpggpa aageqrasps karlkeflqq cdredlvela lpqlaqvvtv yefllmkvae
      541 slgiteflrk keihpdnlgp khlsrdmdge qlegassekr ereaaeegla svkrprreal
      601 sndtteslaa nsrgrekprp lhalaagfsp pvnvtvsprs eeshtttvsg gngsvfqagp
      661 qlqalanlea rrgsigaals srdvsglpvy aqsgeprrlt qaqvaafpge nalehssdqd
      721 twdslrspgf csplssggga eslppggpgh aeaghlgkvc dfhlnhqqps ptsvlpteva
      781 applekilsv dsvavdcayr tvpkpgpqpg phgslltegc lrslsgdlnr fpcgmevhsg
      841 qrelesvvav geamafeisn gshellsqgq kqifiqtsdg lilsppgtiv sqeedivtvt
      901 daegracgwa r
//
LOCUS       XP_011535250             857 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 839 isoform X3 [Homo sapiens].
ACCESSION   XP_011535250
VERSION     XP_011535250.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536948.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XP_011535250.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..857
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..857
                     /product="zinc finger protein 839 isoform X3"
                     /calculated_mol_wt=92466
     Region          53..850
                     /region_name="DUF4764"
                     /note="Domain of unknown function (DUF4764); pfam15961"
                     /db_xref="CDD:464955"
     CDS             1..857
                     /gene="ZNF839"
                     /gene_synonym="C14orf131"
                     /coded_by="XM_011536948.3:76..2649"
                     /db_xref="GeneID:55778"
                     /db_xref="HGNC:HGNC:20345"
ORIGIN      
        1 mlprlalnsw pqavlppqhp kalrlqqlea icvkvtsget kgqerpmllp ttiqpqtark
       61 sqlprgnscl vglhiaspql lrvqplvrte pqscflsdlc qppaqgfvqr plpalqvvpa
      121 krvpapkapd eqgsmltpls asdplavtsl ssssahpfis nlhtrhtekl kkslkvktrs
      181 grvsrppkyk akdykfikte dladghlsds ddyselcvee dedqrerhal fdlsscslrp
      241 ksfkcqtcek syigkgglar hfklnpghgq ldpemvlsek asgstlrgct eertlsltsl
      301 glsmpadpce ggarsclvte sargglqngq svdveetlps epengallrs eryqgprrra
      361 csetlaesrt avlqqrraaq lpggpaaage qraspskarl keflqqcdre dlvelalpql
      421 aqvvtvyefl lmkvekdhla kpffpaiyke feelhkmvkk mcqdylsssg lcsqetlein
      481 ndkvaeslgi teflrkkeih pdnlgpkhls rdmdgeqleg assekrerea aeeglasvkr
      541 prrealsndt teslaansrg rekprplhal aagfsppvnv tvsprseesh tttvsggngs
      601 vfqagpqlqa lanlearrgs igaalssrdv sglpvyaqsg eprrltqaqv aafpgenale
      661 hssdqdtwds lrspgfcspl ssgggaeslp pggpghaeag hlgkvcdfhl nhqqpsptsv
      721 lptevaappl ekilsvdsva vdcayrtvpk pgpqpgphgs lltegclrsl sgdlnrfpcg
      781 mevhsgqrel esvvavgeam afeisngshe llsqgqkqif iqtsdglils ppgtivsqee
      841 divtvtdaeg racgwar
//
LOCUS       XP_006720266             839 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 839 isoform X4 [Homo sapiens].
ACCESSION   XP_006720266
VERSION     XP_006720266.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720203.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Jun 6, 2016 this sequence version replaced XP_006720266.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..839
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..839
                     /product="zinc finger protein 839 isoform X4"
                     /calculated_mol_wt=90402
     Region          35..832
                     /region_name="DUF4764"
                     /note="Domain of unknown function (DUF4764); pfam15961"
                     /db_xref="CDD:464955"
     CDS             1..839
                     /gene="ZNF839"
                     /gene_synonym="C14orf131"
                     /coded_by="XM_006720203.4:2426..4945"
                     /db_xref="GeneID:55778"
                     /db_xref="HGNC:HGNC:20345"
ORIGIN      
        1 mgfhhvgqql eaicvkvtsg etkgqerpml lpttiqpqta rksqlprgns clvglhiasp
       61 qllrvqplvr tepqscflsd lcqppaqgfv qrplpalqvv pakrvpapka pdeqgsmltp
      121 lsasdplavt slssssahpf isnlhtrhte klkkslkvkt rsgrvsrppk ykakdykfik
      181 tedladghls dsddyselcv eededqrerh alfdlsscsl rpksfkcqtc eksyigkggl
      241 arhfklnpgh gqldpemvls ekasgstlrg cteertlslt slglsmpadp ceggarsclv
      301 tesargglqn gqsvdveetl psepengall rseryqgprr racsetlaes rtavlqqrra
      361 aqlpggpaaa geqraspska rlkeflqqcd redlvelalp qlaqvvtvye fllmkvekdh
      421 lakpffpaiy kefeelhkmv kkmcqdylss sglcsqetle inndkvaesl giteflrkke
      481 ihpdnlgpkh lsrdmdgeql egassekrer eaaeeglasv krprrealsn dtteslaans
      541 rgrekprplh alaagfsppv nvtvsprsee shtttvsggn gsvfqagpql qalanlearr
      601 gsigaalssr dvsglpvyaq sgeprrltqa qvaafpgena lehssdqdtw dslrspgfcs
      661 plssgggaes lppggpghae aghlgkvcdf hlnhqqpspt svlptevaap plekilsvds
      721 vavdcayrtv pkpgpqpgph gslltegclr slsgdlnrfp cgmevhsgqr elesvvavge
      781 amafeisngs hellsqgqkq ifiqtsdgli lsppgtivsq eedivtvtda egracgwar
//
LOCUS       XP_011535251             701 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 839 isoform X5 [Homo sapiens].
ACCESSION   XP_011535251
VERSION     XP_011535251.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536949.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..701
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..701
                     /product="zinc finger protein 839 isoform X5"
                     /calculated_mol_wt=75986
     Region          157..>681
                     /region_name="DUF4764"
                     /note="Domain of unknown function (DUF4764); pfam15961"
                     /db_xref="CDD:464955"
     CDS             1..701
                     /gene="ZNF839"
                     /gene_synonym="C14orf131"
                     /coded_by="XM_011536949.4:21..2126"
                     /db_xref="GeneID:55778"
                     /db_xref="HGNC:HGNC:20345"
ORIGIN      
        1 madaepeagg gsedgggggg pappgqsgsv arvaplgpeq lrqvleqvtk aqpppppppf
       61 vlrdaarrlr daaqqaalqr grgtepprlp rllppqgsls afriisgafe radlgaspqe
      121 irfsrsagte qleaicvkvt sgetkgqerp mllpttiqpq tarksqlprg nsclvglhia
      181 spqllrvqpl vrtepqscfl sdlcqppaqg fvqrplpalq vvpakrvpap kapdeqgsml
      241 tplsasdpla vtslssssah pfisnlhtrh teklkkslkv ktrsgrvsrp pkykakdykf
      301 iktedladgh lsdsddysel cveededqre rhalfdlssc slrpksfkcq tceksyigkg
      361 glarhfklnp ghgqldpemv lsekasgstl rgcteertls ltslglsmpa dpceggarsc
      421 lvtesarggl qngqsvdvee tlpsepenga llrseryqgp rrracsetla esrtavlqqr
      481 raaqlpggpa aageqrasps karlkeflqq cdredlvela lpqlaqvvtv yefllmkvek
      541 dhlakpffpa iykefeelhk mvkkmcqdyl sssglcsqet leinndkvae slgiteflrk
      601 keihpdnlgp khlsrdmdge qlegassekr ereaaeegla svkrprreal sndtteslaa
      661 nsrgrekprp lhalaagtiv sqeedivtvt daegracgwa r
//
LOCUS       XP_011535252             651 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 839 isoform X6 [Homo sapiens].
ACCESSION   XP_011535252
VERSION     XP_011535252.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536950.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..651
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..651
                     /product="zinc finger protein 839 isoform X6"
                     /calculated_mol_wt=70141
     Region          157..>631
                     /region_name="DUF4764"
                     /note="Domain of unknown function (DUF4764); pfam15961"
                     /db_xref="CDD:464955"
     CDS             1..651
                     /gene="ZNF839"
                     /gene_synonym="C14orf131"
                     /coded_by="XM_011536950.4:21..1976"
                     /db_xref="GeneID:55778"
                     /db_xref="HGNC:HGNC:20345"
ORIGIN      
        1 madaepeagg gsedgggggg pappgqsgsv arvaplgpeq lrqvleqvtk aqpppppppf
       61 vlrdaarrlr daaqqaalqr grgtepprlp rllppqgsls afriisgafe radlgaspqe
      121 irfsrsagte qleaicvkvt sgetkgqerp mllpttiqpq tarksqlprg nsclvglhia
      181 spqllrvqpl vrtepqscfl sdlcqppaqg fvqrplpalq vvpakrvpap kapdeqgsml
      241 tplsasdpla vtslssssah pfisnlhtrh teklkkslkv ktrsgrvsrp pkykakdykf
      301 iktedladgh lsdsddysel cveededqre rhalfdlssc slrpksfkcq tceksyigkg
      361 glarhfklnp ghgqldpemv lsekasgstl rgcteertls ltslglsmpa dpceggarsc
      421 lvtesarggl qngqsvdvee tlpsepenga llrseryqgp rrracsetla esrtavlqqr
      481 raaqlpggpa aageqrasps karlkeflqq cdredlvela lpqlaqvvtv yefllmkvae
      541 slgiteflrk keihpdnlgp khlsrdmdge qlegassekr ereaaeegla svkrprreal
      601 sndtteslaa nsrgrekprp lhalaagtiv sqeedivtvt daegracgwa r
//
LOCUS       XP_016876938             592 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 839 isoform X7 [Homo sapiens].
ACCESSION   XP_016876938
VERSION     XP_016876938.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021449.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..592
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..592
                     /product="zinc finger protein 839 isoform X7"
                     /calculated_mol_wt=63142
     Region          <62..585
                     /region_name="DUF4764"
                     /note="Domain of unknown function (DUF4764); pfam15961"
                     /db_xref="CDD:464955"
     CDS             1..592
                     /gene="ZNF839"
                     /gene_synonym="C14orf131"
                     /coded_by="XM_017021449.3:287..2065"
                     /db_xref="GeneID:55778"
                     /db_xref="HGNC:HGNC:20345"
ORIGIN      
        1 mgmhpsalgl vsktngsall advaitegve krspwgcfws vnsswllsvs sppsaasatp
       61 dkngqsvdve etlpsepeng allrseryqg prrracsetl aesrtavlqq rraaqlpggp
      121 aaageqrasp skarlkeflq qcdredlvel alpqlaqvvt vyefllmkve kdhlakpffp
      181 aiykefeelh kmvkkmcqdy lsssglcsqe tleinndkva eslgiteflr kkeihpdnlg
      241 pkhlsrdmdg eqlegassek rereaaeegl asvkrprrea lsndttesla ansrgrekpr
      301 plhalaagfs ppvnvtvspr seeshtttvs ggngsvfqag pqlqalanle arrgsigaal
      361 ssrdvsglpv yaqsgeprrl tqaqvaafpg enalehssdq dtwdslrspg fcsplssggg
      421 aeslppggpg haeaghlgkv cdfhlnhqqp sptsvlptev aapplekils vdsvavdcay
      481 rtvpkpgpqp gphgsllteg clrslsgdln rfpcgmevhs gqrelesvva vgeamafeis
      541 ngshellsqg qkqifiqtsd glilsppgti vsqeedivtv tdaegracgw ar
//
LOCUS       XP_005267908             600 aa            linear   PRI 05-AUG-2025
DEFINITION  spermatogenesis-associated protein 7 isoform X1 [Homo sapiens].
ACCESSION   XP_005267908
VERSION     XP_005267908.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267851.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..600
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..600
                     /product="spermatogenesis-associated protein 7 isoform X1"
                     /calculated_mol_wt=67687
     Region          9..421
                     /region_name="HSD3"
                     /note="Spermatogenesis-associated protein 7, or HSD3;
                     pfam15244"
                     /db_xref="CDD:464584"
     CDS             1..600
                     /gene="SPATA7"
                     /gene_synonym="HEL-S-296; HSD-3.1; HSD3; LCA3; RP94"
                     /coded_by="XM_005267851.2:163..1965"
                     /db_xref="GeneID:55812"
                     /db_xref="HGNC:HGNC:20423"
                     /db_xref="MIM:609868"
ORIGIN      
        1 mdgsrrvrat svlprygppc lfkghlstks nafctdsssl rlstlqlvkn hmavhynkil
       61 sakaavdcsv pvsvstsiky adqqrreklk kelaqcekef kltktamran yknnskslfn
      121 tlqkpsgepq ieddmlkeem ngfssfarsl vpsserlhls lhksskvitn gpeknssssp
      181 ssvdyaasgp rklssgalyg rrprstfpns hrfqlviska psgdlldkhs elfsnkqlpf
      241 tprtlkteak sflsqyryyt pakrkkdftd qrieaetqte lsfkselgta etknmtdsem
      301 nikqvasncv tydakekiap lpleghdstw deikddalqh sspramcqys lkppstrkiy
      361 sdeeellyls fiedvtdeil klglfsnrfl erlferhikq nkhleeekmr hllhvlkvdl
      421 gctseensvk qndvdmlnvf dfekagnsep nelknesevt iqqerqqyqk aldmllsapk
      481 deneifpspt effmpiyksk hsegviiqqv ndetnletst ldenhpsisd sltdretsvn
      541 viegdsdpek veisnglcgl ntspsqsvqf ssvkgdnnhd melstlkime msiedcpldv
//
LOCUS       XP_005267909             568 aa            linear   PRI 05-AUG-2025
DEFINITION  spermatogenesis-associated protein 7 isoform X2 [Homo sapiens].
ACCESSION   XP_005267909
VERSION     XP_005267909.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267852.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..568
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..568
                     /product="spermatogenesis-associated protein 7 isoform X2"
                     /calculated_mol_wt=64128
     Region          9..389
                     /region_name="HSD3"
                     /note="Spermatogenesis-associated protein 7, or HSD3;
                     pfam15244"
                     /db_xref="CDD:464584"
     CDS             1..568
                     /gene="SPATA7"
                     /gene_synonym="HEL-S-296; HSD-3.1; HSD3; LCA3; RP94"
                     /coded_by="XM_005267852.3:163..1869"
                     /db_xref="GeneID:55812"
                     /db_xref="HGNC:HGNC:20423"
                     /db_xref="MIM:609868"
ORIGIN      
        1 mdgsrrvrat svlprygppc lfkghlstks naavdcsvpv svstsikyad qqrreklkke
       61 laqcekefkl tktamranyk nnskslfntl qkpsgepqie ddmlkeemng fssfarslvp
      121 sserlhlslh ksskvitngp eknsssspss vdyaasgprk lssgalygrr prstfpnshr
      181 fqlviskaps gdlldkhsel fsnkqlpftp rtlkteaksf lsqyryytpa krkkdftdqr
      241 ieaetqtels fkselgtaet knmtdsemni kqvasncvty dakekiaplp leghdstwde
      301 ikddalqhss pramcqyslk ppstrkiysd eeellylsfi edvtdeilkl glfsnrfler
      361 lferhikqnk hleeekmrhl lhvlkvdlgc tseensvkqn dvdmlnvfdf ekagnsepne
      421 lknesevtiq qerqqyqkal dmllsapkde neifpsptef fmpiykskhs egviiqqvnd
      481 etnletstld enhpsisdsl tdretsvnvi egdsdpekve isnglcglnt spsqsvqfss
      541 vkgdnnhdme lstlkimems iedcpldv
//
LOCUS       XP_011535254             543 aa            linear   PRI 05-AUG-2025
DEFINITION  spermatogenesis-associated protein 7 isoform X3 [Homo sapiens].
ACCESSION   XP_011535254
VERSION     XP_011535254.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536952.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..543
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..543
                     /product="spermatogenesis-associated protein 7 isoform X3"
                     /calculated_mol_wt=61417
     Region          4..364
                     /region_name="HSD3"
                     /note="Spermatogenesis-associated protein 7, or HSD3;
                     pfam15244"
                     /db_xref="CDD:464584"
     CDS             1..543
                     /gene="SPATA7"
                     /gene_synonym="HEL-S-296; HSD-3.1; HSD3; LCA3; RP94"
                     /coded_by="XM_011536952.2:163..1794"
                     /db_xref="GeneID:55812"
                     /db_xref="HGNC:HGNC:20423"
                     /db_xref="MIM:609868"
ORIGIN      
        1 mdgsrraavd csvpvsvsts ikyadqqrre klkkelaqce kefkltktam ranyknnsks
       61 lfntlqkpsg epqieddmlk eemngfssfa rslvpsserl hlslhksskv itngpeknss
      121 sspssvdyaa sgprklssga lygrrprstf pnshrfqlvi skapsgdlld khselfsnkq
      181 lpftprtlkt eaksflsqyr yytpakrkkd ftdqrieaet qtelsfksel gtaetknmtd
      241 semnikqvas ncvtydakek iaplpleghd stwdeikdda lqhsspramc qyslkppstr
      301 kiysdeeell ylsfiedvtd eilklglfsn rflerlferh ikqnkhleee kmrhllhvlk
      361 vdlgctseen svkqndvdml nvfdfekagn sepnelknes evtiqqerqq yqkaldmlls
      421 apkdeneifp spteffmpiy kskhsegvii qqvndetnle tstldenhps isdsltdret
      481 svnviegdsd pekveisngl cglntspsqs vqfssvkgdn nhdmelstlk imemsiedcp
      541 ldv
//
LOCUS       XP_024305428             542 aa            linear   PRI 05-AUG-2025
DEFINITION  spermatogenesis-associated protein 7 isoform X4 [Homo sapiens].
ACCESSION   XP_024305428
VERSION     XP_024305428.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449660.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..542
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..542
                     /product="spermatogenesis-associated protein 7 isoform X4"
                     /calculated_mol_wt=61318
     Region          4..363
                     /region_name="HSD3"
                     /note="Spermatogenesis-associated protein 7, or HSD3;
                     pfam15244"
                     /db_xref="CDD:464584"
     CDS             1..542
                     /gene="SPATA7"
                     /gene_synonym="HEL-S-296; HSD-3.1; HSD3; LCA3; RP94"
                     /coded_by="XM_024449660.2:163..1791"
                     /db_xref="GeneID:55812"
                     /db_xref="HGNC:HGNC:20423"
                     /db_xref="MIM:609868"
ORIGIN      
        1 mdgsrraavd csvpvsvsts ikyadqqrre klkkelaqce kefkltktam ranyknnsks
       61 lfntlqkpsg epqieddmlk eemngfssfa rslvpsserl hlslhksskv itngpeknss
      121 sspssvdyaa sgprklssga lygrrprstf pnshrfqlvi skapsgdlld khselfsnkq
      181 lpftprtlkt eaksflsqyr yytpakrkkd ftdqrieaet qtelsfksel gtaetknmtd
      241 semnikqasn cvtydakeki aplpleghds twdeikddal qhsspramcq yslkppstrk
      301 iysdeeelly lsfiedvtde ilklglfsnr flerlferhi kqnkhleeek mrhllhvlkv
      361 dlgctseens vkqndvdmln vfdfekagns epnelknese vtiqqerqqy qkaldmllsa
      421 pkdeneifps pteffmpiyk skhsegviiq qvndetnlet stldenhpsi sdsltdrets
      481 vnviegdsdp ekveisnglc glntspsqsv qfssvkgdnn hdmelstlki memsiedcpl
      541 dv
//
LOCUS       XP_006720267             445 aa            linear   PRI 05-AUG-2025
DEFINITION  spermatogenesis-associated protein 7 isoform X5 [Homo sapiens].
ACCESSION   XP_006720267
VERSION     XP_006720267.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720204.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..445
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..445
                     /product="spermatogenesis-associated protein 7 isoform X5"
                     /calculated_mol_wt=50156
     Region          9..421
                     /region_name="HSD3"
                     /note="Spermatogenesis-associated protein 7, or HSD3;
                     pfam15244"
                     /db_xref="CDD:464584"
     CDS             1..445
                     /gene="SPATA7"
                     /gene_synonym="HEL-S-296; HSD-3.1; HSD3; LCA3; RP94"
                     /coded_by="XM_006720204.2:163..1500"
                     /db_xref="GeneID:55812"
                     /db_xref="HGNC:HGNC:20423"
                     /db_xref="MIM:609868"
ORIGIN      
        1 mdgsrrvrat svlprygppc lfkghlstks nafctdsssl rlstlqlvkn hmavhynkil
       61 sakaavdcsv pvsvstsiky adqqrreklk kelaqcekef kltktamran yknnskslfn
      121 tlqkpsgepq ieddmlkeem ngfssfarsl vpsserlhls lhksskvitn gpeknssssp
      181 ssvdyaasgp rklssgalyg rrprstfpns hrfqlviska psgdlldkhs elfsnkqlpf
      241 tprtlkteak sflsqyryyt pakrkkdftd qrieaetqte lsfkselgta etknmtdsem
      301 nikqvasncv tydakekiap lpleghdstw deikddalqh sspramcqys lkppstrkiy
      361 sdeeellyls fiedvtdeil klglfsnrfl erlferhikq nkhleeekmr hllhvlkvdl
      421 gctseensip daattgpktt plede
//
LOCUS       XP_006720268             434 aa            linear   PRI 05-AUG-2025
DEFINITION  spermatogenesis-associated protein 7 isoform X6 [Homo sapiens].
ACCESSION   XP_006720268
VERSION     XP_006720268.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720205.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..434
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..434
                     /product="spermatogenesis-associated protein 7 isoform X6"
                     /calculated_mol_wt=49114
     Region          9..421
                     /region_name="HSD3"
                     /note="Spermatogenesis-associated protein 7, or HSD3;
                     pfam15244"
                     /db_xref="CDD:464584"
     CDS             1..434
                     /gene="SPATA7"
                     /gene_synonym="HEL-S-296; HSD-3.1; HSD3; LCA3; RP94"
                     /coded_by="XM_006720205.2:163..1467"
                     /db_xref="GeneID:55812"
                     /db_xref="HGNC:HGNC:20423"
                     /db_xref="MIM:609868"
ORIGIN      
        1 mdgsrrvrat svlprygppc lfkghlstks nafctdsssl rlstlqlvkn hmavhynkil
       61 sakaavdcsv pvsvstsiky adqqrreklk kelaqcekef kltktamran yknnskslfn
      121 tlqkpsgepq ieddmlkeem ngfssfarsl vpsserlhls lhksskvitn gpeknssssp
      181 ssvdyaasgp rklssgalyg rrprstfpns hrfqlviska psgdlldkhs elfsnkqlpf
      241 tprtlkteak sflsqyryyt pakrkkdftd qrieaetqte lsfkselgta etknmtdsem
      301 nikqvasncv tydakekiap lpleghdstw deikddalqh sspramcqys lkppstrkiy
      361 sdeeellyls fiedvtdeil klglfsnrfl erlferhikq nkhleeekmr hllhvlkvdl
      421 gctseensvr ipdd
//
LOCUS       XP_047287537             433 aa            linear   PRI 05-AUG-2025
DEFINITION  spermatogenesis-associated protein 7 isoform X7 [Homo sapiens].
ACCESSION   XP_047287537
VERSION     XP_047287537.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431581.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..433
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..433
                     /product="spermatogenesis-associated protein 7 isoform X7"
                     /calculated_mol_wt=49015
     Region          9..420
                     /region_name="HSD3"
                     /note="Spermatogenesis-associated protein 7, or HSD3;
                     pfam15244"
                     /db_xref="CDD:464584"
     CDS             1..433
                     /gene="SPATA7"
                     /gene_synonym="HEL-S-296; HSD-3.1; HSD3; LCA3; RP94"
                     /coded_by="XM_047431581.1:163..1464"
                     /db_xref="GeneID:55812"
                     /db_xref="HGNC:HGNC:20423"
                     /db_xref="MIM:609868"
ORIGIN      
        1 mdgsrrvrat svlprygppc lfkghlstks nafctdsssl rlstlqlvkn hmavhynkil
       61 sakaavdcsv pvsvstsiky adqqrreklk kelaqcekef kltktamran yknnskslfn
      121 tlqkpsgepq ieddmlkeem ngfssfarsl vpsserlhls lhksskvitn gpeknssssp
      181 ssvdyaasgp rklssgalyg rrprstfpns hrfqlviska psgdlldkhs elfsnkqlpf
      241 tprtlkteak sflsqyryyt pakrkkdftd qrieaetqte lsfkselgta etknmtdsem
      301 nikqasncvt ydakekiapl pleghdstwd eikddalqhs spramcqysl kppstrkiys
      361 deeellylsf iedvtdeilk lglfsnrfle rlferhikqn khleeekmrh llhvlkvdlg
      421 ctseensvri pdd
//
LOCUS       XP_047287538             412 aa            linear   PRI 05-AUG-2025
DEFINITION  spermatogenesis-associated protein 7 isoform X8 [Homo sapiens].
ACCESSION   XP_047287538
VERSION     XP_047287538.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431582.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..412
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..412
                     /product="spermatogenesis-associated protein 7 isoform X8"
                     /calculated_mol_wt=46498
     Region          9..388
                     /region_name="HSD3"
                     /note="Spermatogenesis-associated protein 7, or HSD3;
                     pfam15244"
                     /db_xref="CDD:464584"
     CDS             1..412
                     /gene="SPATA7"
                     /gene_synonym="HEL-S-296; HSD-3.1; HSD3; LCA3; RP94"
                     /coded_by="XM_047431582.1:163..1401"
                     /db_xref="GeneID:55812"
                     /db_xref="HGNC:HGNC:20423"
                     /db_xref="MIM:609868"
ORIGIN      
        1 mdgsrrvrat svlprygppc lfkghlstks naavdcsvpv svstsikyad qqrreklkke
       61 laqcekefkl tktamranyk nnskslfntl qkpsgepqie ddmlkeemng fssfarslvp
      121 sserlhlslh ksskvitngp eknsssspss vdyaasgprk lssgalygrr prstfpnshr
      181 fqlviskaps gdlldkhsel fsnkqlpftp rtlkteaksf lsqyryytpa krkkdftdqr
      241 ieaetqtels fkselgtaet knmtdsemni kqasncvtyd akekiaplpl eghdstwdei
      301 kddalqhssp ramcqyslkp pstrkiysde eellylsfie dvtdeilklg lfsnrflerl
      361 ferhikqnkh leeekmrhll hvlkvdlgct seensipdaa ttgpkttple de
//
LOCUS       XP_047287540             401 aa            linear   PRI 05-AUG-2025
DEFINITION  spermatogenesis-associated protein 7 isoform X9 [Homo sapiens].
ACCESSION   XP_047287540
VERSION     XP_047287540.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431584.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..401
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..401
                     /product="spermatogenesis-associated protein 7 isoform X9"
                     /calculated_mol_wt=45456
     Region          9..388
                     /region_name="HSD3"
                     /note="Spermatogenesis-associated protein 7, or HSD3;
                     pfam15244"
                     /db_xref="CDD:464584"
     CDS             1..401
                     /gene="SPATA7"
                     /gene_synonym="HEL-S-296; HSD-3.1; HSD3; LCA3; RP94"
                     /coded_by="XM_047431584.1:163..1368"
                     /db_xref="GeneID:55812"
                     /db_xref="HGNC:HGNC:20423"
                     /db_xref="MIM:609868"
ORIGIN      
        1 mdgsrrvrat svlprygppc lfkghlstks naavdcsvpv svstsikyad qqrreklkke
       61 laqcekefkl tktamranyk nnskslfntl qkpsgepqie ddmlkeemng fssfarslvp
      121 sserlhlslh ksskvitngp eknsssspss vdyaasgprk lssgalygrr prstfpnshr
      181 fqlviskaps gdlldkhsel fsnkqlpftp rtlkteaksf lsqyryytpa krkkdftdqr
      241 ieaetqtels fkselgtaet knmtdsemni kqasncvtyd akekiaplpl eghdstwdei
      301 kddalqhssp ramcqyslkp pstrkiysde eellylsfie dvtdeilklg lfsnrflerl
      361 ferhikqnkh leeekmrhll hvlkvdlgct seensvripd d
//
LOCUS       XP_047287541             782 aa            linear   PRI 05-AUG-2025
DEFINITION  protein kinase C eta type isoform X1 [Homo sapiens].
ACCESSION   XP_047287541
VERSION     XP_047287541.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431585.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..782
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..782
                     /product="protein kinase C eta type isoform X1"
                     /calculated_mol_wt=88585
     Region          8..122
                     /region_name="C2_PKC_epsilon"
                     /note="C2 domain in Protein Kinase C (PKC) epsilon;
                     cd04014"
                     /db_xref="CDD:175981"
     Site            order(42,89,95)
                     /site_type="metal-binding"
                     /note="metal binding pocket [ion binding]"
                     /db_xref="CDD:175981"
     Region          265..325
                     /region_name="C1_nPKC_epsilon-like_rpt1"
                     /note="first protein kinase C conserved region 1 (C1
                     domain) found in novel protein kinase C (nPKC) epsilon,
                     eta, and similar proteins; cd20835"
                     /db_xref="CDD:410385"
     Site            order(276..282,290..294,298)
                     /site_type="other"
                     /note="putative DAG/PE binding site [chemical binding]"
                     /db_xref="CDD:410385"
     Region          343..397
                     /region_name="C1_nPKC_epsilon-like_rpt2"
                     /note="second protein kinase C conserved region 1 (C1
                     domain) found in novel protein kinase C (nPKC) epsilon,
                     eta, and similar proteins; cd20838"
                     /db_xref="CDD:410388"
     Site            order(350..356,364..368,371)
                     /site_type="other"
                     /note="putative DAG/PE binding site [chemical binding]"
                     /db_xref="CDD:410388"
     Region          458..780
                     /region_name="STKc_nPKC_eta"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     Novel Protein Kinase C eta; cd05590"
                     /db_xref="CDD:270742"
     Site            order(460..464,468,481,483,516,532..533,535,539,541,578,
                     580,582..583,585,595..596,599,613..618,645,651,654)
                     /site_type="active"
                     /db_xref="CDD:270742"
     Site            order(460..464,468,481,483,516,533..535,539,578,580,
                     582..583,585,595..596)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270742"
     Site            order(464,539,541,578,580,582,599,613..618,645,651,654)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270742"
     Site            595..618
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270742"
     Site            755
                     /site_type="other"
                     /note="turn motif phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:270742"
     Site            770..775
                     /site_type="other"
                     /note="hydrophobic motif (HM)"
                     /db_xref="CDD:270742"
     CDS             1..782
                     /gene="PRKCH"
                     /gene_synonym="nPKC-eta; PKC-L; PKCL; PRKCL; uORF2"
                     /coded_by="XM_047431585.1:383..2731"
                     /db_xref="GeneID:5583"
                     /db_xref="HGNC:HGNC:9403"
                     /db_xref="MIM:605437"
ORIGIN      
        1 mssgtmkfng ylrvrigeav glqptrwslr hslfkkghql ldpyltvsvd qvrvgqtstk
       61 qktnkptyne efcanvtdgg hlelavfhet plgydhfvan ctlqfqellr ttgasdtfeg
      121 wvssgdpfpl cppnprspyv fqnspgsrfp ialwlrefpp dfglrprgrg tgdatavgvc
      181 rrrcvsrkpa wtrspfrtaa wpngksgrgp grspfppslw vdlepegkvf vvitltgsft
      241 eatlqrdrif khftrkrqra mrrrvhqing hkfmatylrq ptycshcref iwgvfgkqgy
      301 qcqvctcvvh krchhlivta ctcqnninkv dskiaeqrfg iniphkfsih nykvptfcdh
      361 cgsllwgimr qglqckickm nvhircqanv apncgvnave laktlagmgl qpgnisptsk
      421 lvsrstlrrq gkesskegng igvnssnrlg idnfefirvl gkgsfgkvml arvketgdly
      481 avkvlkkdvi lqdddvectm tekrilslar nhpfltqlfc cfqtpdrlff vmefvnggdl
      541 mfhiqksrrf deararfyaa eiisalmflh dkgiiyrdlk ldnvlldheg hckladfgmc
      601 kegicngvtt atfcgtpdyi apeilqemly gpavdwwamg vllyemlcgh apfeaenedd
      661 lfeailndev vyptwlheda tgilksfmtk nptmrlgslt qggehailrh pffkeidwaq
      721 lnhrqieppf rpriksredv snfdpdfike epvltpideg hlpminqdef rnfsyvspel
      781 qp
//
LOCUS       XP_011535256             604 aa            linear   PRI 05-AUG-2025
DEFINITION  protein kinase C eta type isoform X2 [Homo sapiens].
ACCESSION   XP_011535256
VERSION     XP_011535256.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536954.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..604
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..604
                     /product="protein kinase C eta type isoform X2"
                     /calculated_mol_wt=68534
     Region          87..147
                     /region_name="C1_nPKC_epsilon-like_rpt1"
                     /note="first protein kinase C conserved region 1 (C1
                     domain) found in novel protein kinase C (nPKC) epsilon,
                     eta, and similar proteins; cd20835"
                     /db_xref="CDD:410385"
     Site            order(98..104,112..116,120)
                     /site_type="other"
                     /note="putative DAG/PE binding site [chemical binding]"
                     /db_xref="CDD:410385"
     Region          165..219
                     /region_name="C1_nPKC_epsilon-like_rpt2"
                     /note="second protein kinase C conserved region 1 (C1
                     domain) found in novel protein kinase C (nPKC) epsilon,
                     eta, and similar proteins; cd20838"
                     /db_xref="CDD:410388"
     Site            order(172..178,186..190,193)
                     /site_type="other"
                     /note="putative DAG/PE binding site [chemical binding]"
                     /db_xref="CDD:410388"
     Region          280..602
                     /region_name="STKc_nPKC_eta"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     Novel Protein Kinase C eta; cd05590"
                     /db_xref="CDD:270742"
     Site            order(282..286,290,303,305,338,354..355,357,361,363,400,
                     402,404..405,407,417..418,421,435..440,467,473,476)
                     /site_type="active"
                     /db_xref="CDD:270742"
     Site            order(282..286,290,303,305,338,355..357,361,400,402,
                     404..405,407,417..418)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270742"
     Site            order(286,361,363,400,402,404,421,435..440,467,473,476)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270742"
     Site            417..440
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270742"
     Site            577
                     /site_type="other"
                     /note="turn motif phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:270742"
     Site            592..597
                     /site_type="other"
                     /note="hydrophobic motif (HM)"
                     /db_xref="CDD:270742"
     CDS             1..604
                     /gene="PRKCH"
                     /gene_synonym="nPKC-eta; PKC-L; PKCL; PRKCL; uORF2"
                     /coded_by="XM_011536954.4:8192..10006"
                     /db_xref="GeneID:5583"
                     /db_xref="HGNC:HGNC:9403"
                     /db_xref="MIM:605437"
ORIGIN      
        1 mnhgsrsgag vdpgetsrvd vlgsesdsmy llrswasgva ywvdlepegk vfvvitltgs
       61 fteatlqrdr ifkhftrkrq ramrrrvhqi nghkfmatyl rqptycshcr efiwgvfgkq
      121 gyqcqvctcv vhkrchhliv tactcqnnin kvdskiaeqr fginiphkfs ihnykvptfc
      181 dhcgsllwgi mrqglqckic kmnvhircqa nvapncgvna velaktlagm glqpgnispt
      241 sklvsrstlr rqgkesskeg ngigvnssnr lgidnfefir vlgkgsfgkv mlarvketgd
      301 lyavkvlkkd vilqdddvec tmtekrilsl arnhpfltql fccfqtpdrl ffvmefvngg
      361 dlmfhiqksr rfdeararfy aaeiisalmf lhdkgiiyrd lkldnvlldh eghckladfg
      421 mckegicngv ttatfcgtpd yiapeilqem lygpavdwwa mgvllyemlc ghapfeaene
      481 ddlfeailnd evvyptwlhe datgilksfm tknptmrlgs ltqggehail rhpffkeidw
      541 aqlnhrqiep pfrpriksre dvsnfdpdfi keepvltpid eghlpminqd efrnfsyvsp
      601 elqp
//
LOCUS       XP_011535257             603 aa            linear   PRI 05-AUG-2025
DEFINITION  protein kinase C eta type isoform X3 [Homo sapiens].
ACCESSION   XP_011535257
VERSION     XP_011535257.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536955.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..603
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..603
                     /product="protein kinase C eta type isoform X3"
                     /calculated_mol_wt=68949
     Region          86..146
                     /region_name="C1_nPKC_epsilon-like_rpt1"
                     /note="first protein kinase C conserved region 1 (C1
                     domain) found in novel protein kinase C (nPKC) epsilon,
                     eta, and similar proteins; cd20835"
                     /db_xref="CDD:410385"
     Site            order(97..103,111..115,119)
                     /site_type="other"
                     /note="putative DAG/PE binding site [chemical binding]"
                     /db_xref="CDD:410385"
     Region          164..218
                     /region_name="C1_nPKC_epsilon-like_rpt2"
                     /note="second protein kinase C conserved region 1 (C1
                     domain) found in novel protein kinase C (nPKC) epsilon,
                     eta, and similar proteins; cd20838"
                     /db_xref="CDD:410388"
     Site            order(171..177,185..189,192)
                     /site_type="other"
                     /note="putative DAG/PE binding site [chemical binding]"
                     /db_xref="CDD:410388"
     Region          279..601
                     /region_name="STKc_nPKC_eta"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     Novel Protein Kinase C eta; cd05590"
                     /db_xref="CDD:270742"
     Site            order(281..285,289,302,304,337,353..354,356,360,362,399,
                     401,403..404,406,416..417,420,434..439,466,472,475)
                     /site_type="active"
                     /db_xref="CDD:270742"
     Site            order(281..285,289,302,304,337,354..356,360,399,401,
                     403..404,406,416..417)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270742"
     Site            order(285,360,362,399,401,403,420,434..439,466,472,475)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270742"
     Site            416..439
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270742"
     Site            576
                     /site_type="other"
                     /note="turn motif phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:270742"
     Site            591..596
                     /site_type="other"
                     /note="hydrophobic motif (HM)"
                     /db_xref="CDD:270742"
     CDS             1..603
                     /gene="PRKCH"
                     /gene_synonym="nPKC-eta; PKC-L; PKCL; PRKCL; uORF2"
                     /coded_by="XM_011536955.2:3206..5017"
                     /db_xref="GeneID:5583"
                     /db_xref="HGNC:HGNC:9403"
                     /db_xref="MIM:605437"
ORIGIN      
        1 mlygvfrkld ymqrttpyek tssciacrmh vlifqlignf kvdlepegkv fvvitltgsf
       61 teatlqrdri fkhftrkrqr amrrrvhqin ghkfmatylr qptycshcre fiwgvfgkqg
      121 yqcqvctcvv hkrchhlivt actcqnnink vdskiaeqrf giniphkfsi hnykvptfcd
      181 hcgsllwgim rqglqckick mnvhircqan vapncgvnav elaktlagmg lqpgnispts
      241 klvsrstlrr qgkesskegn gigvnssnrl gidnfefirv lgkgsfgkvm larvketgdl
      301 yavkvlkkdv ilqdddvect mtekrilsla rnhpfltqlf ccfqtpdrlf fvmefvnggd
      361 lmfhiqksrr fdeararfya aeiisalmfl hdkgiiyrdl kldnvlldhe ghckladfgm
      421 ckegicngvt tatfcgtpdy iapeilqeml ygpavdwwam gvllyemlcg hapfeaened
      481 dlfeailnde vvyptwlhed atgilksfmt knptmrlgsl tqggehailr hpffkeidwa
      541 qlnhrqiepp frpriksred vsnfdpdfik eepvltpide ghlpminqde frnfsyvspe
      601 lqp
//
LOCUS       XP_024305430             522 aa            linear   PRI 05-AUG-2025
DEFINITION  protein kinase C eta type isoform X4 [Homo sapiens].
ACCESSION   XP_024305430
VERSION     XP_024305430.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449662.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..522
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..522
                     /product="protein kinase C eta type isoform X4"
                     /calculated_mol_wt=59390
     Region          2..65
                     /region_name="C1_nPKC_epsilon-like_rpt1"
                     /note="first protein kinase C conserved region 1 (C1
                     domain) found in novel protein kinase C (nPKC) epsilon,
                     eta, and similar proteins; cd20835"
                     /db_xref="CDD:410385"
     Site            order(16..22,30..34,38)
                     /site_type="other"
                     /note="putative DAG/PE binding site [chemical binding]"
                     /db_xref="CDD:410385"
     Region          83..137
                     /region_name="C1_nPKC_epsilon-like_rpt2"
                     /note="second protein kinase C conserved region 1 (C1
                     domain) found in novel protein kinase C (nPKC) epsilon,
                     eta, and similar proteins; cd20838"
                     /db_xref="CDD:410388"
     Site            order(90..96,104..108,111)
                     /site_type="other"
                     /note="putative DAG/PE binding site [chemical binding]"
                     /db_xref="CDD:410388"
     Region          198..520
                     /region_name="STKc_nPKC_eta"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     Novel Protein Kinase C eta; cd05590"
                     /db_xref="CDD:270742"
     Site            order(200..204,208,221,223,256,272..273,275,279,281,318,
                     320,322..323,325,335..336,339,353..358,385,391,394)
                     /site_type="active"
                     /db_xref="CDD:270742"
     Site            order(200..204,208,221,223,256,273..275,279,318,320,
                     322..323,325,335..336)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270742"
     Site            order(204,279,281,318,320,322,339,353..358,385,391,394)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270742"
     Site            335..358
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270742"
     Site            495
                     /site_type="other"
                     /note="turn motif phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:270742"
     Site            510..515
                     /site_type="other"
                     /note="hydrophobic motif (HM)"
                     /db_xref="CDD:270742"
     CDS             1..522
                     /gene="PRKCH"
                     /gene_synonym="nPKC-eta; PKC-L; PKCL; PRKCL; uORF2"
                     /coded_by="XM_024449662.2:140..1708"
                     /db_xref="GeneID:5583"
                     /db_xref="HGNC:HGNC:9403"
                     /db_xref="MIM:605437"
ORIGIN      
        1 mrrrvhqing hkfmatylrq ptycshcref iwgvfgkqgy qcqvctcvvh krchhlivta
       61 ctcqnninkv dskiaeqrfg iniphkfsih nykvptfcdh cgsllwgimr qglqckickm
      121 nvhircqanv apncgvnave laktlagmgl qpgnisptsk lvsrstlrrq gkesskegng
      181 igvnssnrlg idnfefirvl gkgsfgkvml arvketgdly avkvlkkdvi lqdddvectm
      241 tekrilslar nhpfltqlfc cfqtpdrlff vmefvnggdl mfhiqksrrf deararfyaa
      301 eiisalmflh dkgiiyrdlk ldnvlldheg hckladfgmc kegicngvtt atfcgtpdyi
      361 apeilqemly gpavdwwamg vllyemlcgh apfeaenedd lfeailndev vyptwlheda
      421 tgilksfmtk nptmrlgslt qggehailrh pffkeidwaq lnhrqieppf rpriksredv
      481 snfdpdfike epvltpideg hlpminqdef rnfsyvspel qp
//
LOCUS       XP_024305429             522 aa            linear   PRI 05-AUG-2025
DEFINITION  protein kinase C eta type isoform X4 [Homo sapiens].
ACCESSION   XP_024305429
VERSION     XP_024305429.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449661.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..522
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..522
                     /product="protein kinase C eta type isoform X4"
                     /calculated_mol_wt=59390
     Region          2..65
                     /region_name="C1_nPKC_epsilon-like_rpt1"
                     /note="first protein kinase C conserved region 1 (C1
                     domain) found in novel protein kinase C (nPKC) epsilon,
                     eta, and similar proteins; cd20835"
                     /db_xref="CDD:410385"
     Site            order(16..22,30..34,38)
                     /site_type="other"
                     /note="putative DAG/PE binding site [chemical binding]"
                     /db_xref="CDD:410385"
     Region          83..137
                     /region_name="C1_nPKC_epsilon-like_rpt2"
                     /note="second protein kinase C conserved region 1 (C1
                     domain) found in novel protein kinase C (nPKC) epsilon,
                     eta, and similar proteins; cd20838"
                     /db_xref="CDD:410388"
     Site            order(90..96,104..108,111)
                     /site_type="other"
                     /note="putative DAG/PE binding site [chemical binding]"
                     /db_xref="CDD:410388"
     Region          198..520
                     /region_name="STKc_nPKC_eta"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     Novel Protein Kinase C eta; cd05590"
                     /db_xref="CDD:270742"
     Site            order(200..204,208,221,223,256,272..273,275,279,281,318,
                     320,322..323,325,335..336,339,353..358,385,391,394)
                     /site_type="active"
                     /db_xref="CDD:270742"
     Site            order(200..204,208,221,223,256,273..275,279,318,320,
                     322..323,325,335..336)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270742"
     Site            order(204,279,281,318,320,322,339,353..358,385,391,394)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270742"
     Site            335..358
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270742"
     Site            495
                     /site_type="other"
                     /note="turn motif phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:270742"
     Site            510..515
                     /site_type="other"
                     /note="hydrophobic motif (HM)"
                     /db_xref="CDD:270742"
     CDS             1..522
                     /gene="PRKCH"
                     /gene_synonym="nPKC-eta; PKC-L; PKCL; PRKCL; uORF2"
                     /coded_by="XM_024449661.2:322..1890"
                     /db_xref="GeneID:5583"
                     /db_xref="HGNC:HGNC:9403"
                     /db_xref="MIM:605437"
ORIGIN      
        1 mrrrvhqing hkfmatylrq ptycshcref iwgvfgkqgy qcqvctcvvh krchhlivta
       61 ctcqnninkv dskiaeqrfg iniphkfsih nykvptfcdh cgsllwgimr qglqckickm
      121 nvhircqanv apncgvnave laktlagmgl qpgnisptsk lvsrstlrrq gkesskegng
      181 igvnssnrlg idnfefirvl gkgsfgkvml arvketgdly avkvlkkdvi lqdddvectm
      241 tekrilslar nhpfltqlfc cfqtpdrlff vmefvnggdl mfhiqksrrf deararfyaa
      301 eiisalmflh dkgiiyrdlk ldnvlldheg hckladfgmc kegicngvtt atfcgtpdyi
      361 apeilqemly gpavdwwamg vllyemlcgh apfeaenedd lfeailndev vyptwlheda
      421 tgilksfmtk nptmrlgslt qggehailrh pffkeidwaq lnhrqieppf rpriksredv
      481 snfdpdfike epvltpideg hlpminqdef rnfsyvspel qp
//
LOCUS       XP_047287542             508 aa            linear   PRI 05-AUG-2025
DEFINITION  protein kinase C eta type isoform X5 [Homo sapiens].
ACCESSION   XP_047287542
VERSION     XP_047287542.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431586.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..508
                     /product="protein kinase C eta type isoform X5"
                     /calculated_mol_wt=57533
     Region          8..140
                     /region_name="C2_PKC_epsilon"
                     /note="C2 domain in Protein Kinase C (PKC) epsilon;
                     cd04014"
                     /db_xref="CDD:175981"
     Site            order(42,89,95)
                     /site_type="metal-binding"
                     /note="metal binding pocket [ion binding]"
                     /db_xref="CDD:175981"
     Region          166..226
                     /region_name="C1_nPKC_epsilon-like_rpt1"
                     /note="first protein kinase C conserved region 1 (C1
                     domain) found in novel protein kinase C (nPKC) epsilon,
                     eta, and similar proteins; cd20835"
                     /db_xref="CDD:410385"
     Site            order(177..183,191..195,199)
                     /site_type="other"
                     /note="putative DAG/PE binding site [chemical binding]"
                     /db_xref="CDD:410385"
     Region          244..298
                     /region_name="C1_nPKC_epsilon-like_rpt2"
                     /note="second protein kinase C conserved region 1 (C1
                     domain) found in novel protein kinase C (nPKC) epsilon,
                     eta, and similar proteins; cd20838"
                     /db_xref="CDD:410388"
     Site            order(251..257,265..269,272)
                     /site_type="other"
                     /note="putative DAG/PE binding site [chemical binding]"
                     /db_xref="CDD:410388"
     Region          317..398
                     /region_name="DarA_N"
                     /note="Defence against restriction A N-terminal;
                     pfam18788"
                     /db_xref="CDD:436737"
     Region          359..>492
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Site            order(361..364,367,369,382,384,417,433..436,478..479,481,
                     491..492)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270742"
     CDS             1..508
                     /gene="PRKCH"
                     /gene_synonym="nPKC-eta; PKC-L; PKCL; PRKCL; uORF2"
                     /coded_by="XM_047431586.1:524..2050"
                     /db_xref="GeneID:5583"
                     /db_xref="HGNC:HGNC:9403"
                     /db_xref="MIM:605437"
ORIGIN      
        1 mssgtmkfng ylrvrigeav glqptrwslr hslfkkghql ldpyltvsvd qvrvgqtstk
       61 qktnkptyne efcanvtdgg hlelavfhet plgydhfvan ctlqfqellr ttgasdtfeg
      121 wvdlepegkv fvvitltgsf teatlqrdri fkhftrkrqr amrrrvhqin ghkfmatylr
      181 qptycshcre fiwgvfgkqg yqcqvctcvv hkrchhlivt actcqnnink vdskiaeqrf
      241 giniphkfsi hnykvptfcd hcgsllwgim rqglqckick mnvhircqan vapncgvnav
      301 elaktlagmg lqpgnispts klvsrstlrr qgkesskegn gigvnssnrl gidnfefirv
      361 lgkgsfgkvm larvketgdl yavkvlkkdv ilqdddvect mtekrilsla rnhpfltqlf
      421 ccfqtpdrlf fvmefvnggd lmfhiqksrr fdeararfya aeiisalmfl hdkgiiysts
      481 cqdhagaakk edrctdrafw ntvrgmls
//
LOCUS       XP_011535259             489 aa            linear   PRI 05-AUG-2025
DEFINITION  protein kinase C eta type isoform X6 [Homo sapiens].
ACCESSION   XP_011535259
VERSION     XP_011535259.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536957.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..489
                     /product="protein kinase C eta type isoform X6"
                     /calculated_mol_wt=55541
     Region          8..140
                     /region_name="C2_PKC_epsilon"
                     /note="C2 domain in Protein Kinase C (PKC) epsilon;
                     cd04014"
                     /db_xref="CDD:175981"
     Site            order(42,89,95)
                     /site_type="metal-binding"
                     /note="metal binding pocket [ion binding]"
                     /db_xref="CDD:175981"
     Region          166..226
                     /region_name="C1_nPKC_epsilon-like_rpt1"
                     /note="first protein kinase C conserved region 1 (C1
                     domain) found in novel protein kinase C (nPKC) epsilon,
                     eta, and similar proteins; cd20835"
                     /db_xref="CDD:410385"
     Site            order(177..183,191..195,199)
                     /site_type="other"
                     /note="putative DAG/PE binding site [chemical binding]"
                     /db_xref="CDD:410385"
     Region          244..298
                     /region_name="C1_nPKC_epsilon-like_rpt2"
                     /note="second protein kinase C conserved region 1 (C1
                     domain) found in novel protein kinase C (nPKC) epsilon,
                     eta, and similar proteins; cd20838"
                     /db_xref="CDD:410388"
     Site            order(251..257,265..269,272)
                     /site_type="other"
                     /note="putative DAG/PE binding site [chemical binding]"
                     /db_xref="CDD:410388"
     Region          317..398
                     /region_name="DarA_N"
                     /note="Defence against restriction A N-terminal;
                     pfam18788"
                     /db_xref="CDD:436737"
     Region          359..>478
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..489
                     /gene="PRKCH"
                     /gene_synonym="nPKC-eta; PKC-L; PKCL; PRKCL; uORF2"
                     /coded_by="XM_011536957.2:524..1993"
                     /db_xref="GeneID:5583"
                     /db_xref="HGNC:HGNC:9403"
                     /db_xref="MIM:605437"
ORIGIN      
        1 mssgtmkfng ylrvrigeav glqptrwslr hslfkkghql ldpyltvsvd qvrvgqtstk
       61 qktnkptyne efcanvtdgg hlelavfhet plgydhfvan ctlqfqellr ttgasdtfeg
      121 wvdlepegkv fvvitltgsf teatlqrdri fkhftrkrqr amrrrvhqin ghkfmatylr
      181 qptycshcre fiwgvfgkqg yqcqvctcvv hkrchhlivt actcqnnink vdskiaeqrf
      241 giniphkfsi hnykvptfcd hcgsllwgim rqglqckick mnvhircqan vapncgvnav
      301 elaktlagmg lqpgnispts klvsrstlrr qgkesskegn gigvnssnrl gidnfefirv
      361 lgkgsfgkvm larvketgdl yavkvlkkdv ilqdddvect mtekrilsla rnhpfltqlf
      421 ccfqtpdrlf fvmefvnggd lmfhiqksrr fdeararfya aeiisalmfl hdkgiiyrta
      481 yiflwsahs
//
LOCUS       XP_011535262             424 aa            linear   PRI 05-AUG-2025
DEFINITION  actin-related protein 10 isoform X1 [Homo sapiens].
ACCESSION   XP_011535262
VERSION     XP_011535262.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536960.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..424
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..424
                     /product="actin-related protein 10 isoform X1"
                     /calculated_mol_wt=46995
     Region          16..397
                     /region_name="ASKHA_NBD_Arp10"
                     /note="nucleotide-binding domain (NBD) of actin-related
                     protein 10 (Arp10) and similar proteins; cd10207"
                     /db_xref="CDD:466813"
     CDS             1..424
                     /gene="ACTR10"
                     /gene_synonym="ACTR11; Arp10; Arp11; HARP11"
                     /coded_by="XM_011536960.2:70..1344"
                     /db_xref="GeneID:55860"
                     /db_xref="HGNC:HGNC:17372"
                     /db_xref="MIM:619731"
ORIGIN      
        1 mplyeglgsg gektavvidl geaftkcgfa getgprciip svikragmpk pvrvvqynin
       61 teelysylke fihilyfrhl lvnprdrrvv iiesvlcpsh fretltrvlf kyfevpsvll
      121 apshlmallt lginsamvld cgyreslvlp iyegipvlnc wgalplggka lhkeletqll
      181 eqctvdtsva keqslpsvmg svpegvledi kgllfflkar tcfvsdlkrg lkiqaakfni
      241 dgnnerpspp pnvdypldge kilhilgsir dsvveilfeq dneeqsvatl ildsliqcpi
      301 dtrkqlaenl vviggtsmlp gflhrllaei rylvekpkyk kalgtktfri htppakancv
      361 awlggaifga lqdilgsrsv skeyynqtgr ipdwcslnnp plemmfdvgk tqpplmkraf
      421 stek
//
LOCUS       XP_011535263             405 aa            linear   PRI 05-AUG-2025
DEFINITION  actin-related protein 10 isoform X2 [Homo sapiens].
ACCESSION   XP_011535263
VERSION     XP_011535263.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536961.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..405
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..405
                     /product="actin-related protein 10 isoform X2"
                     /calculated_mol_wt=44952
     Region          16..378
                     /region_name="ASKHA_NBD_Arp10"
                     /note="nucleotide-binding domain (NBD) of actin-related
                     protein 10 (Arp10) and similar proteins; cd10207"
                     /db_xref="CDD:466813"
     CDS             1..405
                     /gene="ACTR10"
                     /gene_synonym="ACTR11; Arp10; Arp11; HARP11"
                     /coded_by="XM_011536961.2:70..1287"
                     /db_xref="GeneID:55860"
                     /db_xref="HGNC:HGNC:17372"
                     /db_xref="MIM:619731"
ORIGIN      
        1 mplyeglgsg gektavvidl geaftkcgfa getgprciip svikragmpk pvrvvqynin
       61 teelysylke fihilyfrhl lvnprdrrvv iiesvlcpsh fretltrvlf kyfevpsvll
      121 apshlmallt lginsamvld cgyreslvlp iyegipvlnc wgalplggka lhkeletqll
      181 eqctvdtsva keqslpsvma rtcfvsdlkr glkiqaakfn idgnnerpsp ppnvdypldg
      241 ekilhilgsi rdsvveilfe qdneeqsvat lildsliqcp idtrkqlaen lvviggtsml
      301 pgflhrllae irylvekpky kkalgtktfr ihtppakanc vawlggaifg alqdilgsrs
      361 vskeyynqtg ripdwcslnn pplemmfdvg ktqpplmkra fstek
//
LOCUS       XP_047287543             226 aa            linear   PRI 05-AUG-2025
DEFINITION  actin-related protein 10 isoform X3 [Homo sapiens].
ACCESSION   XP_047287543
VERSION     XP_047287543.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431587.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..226
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..226
                     /product="actin-related protein 10 isoform X3"
                     /calculated_mol_wt=25024
     Region          <1..199
                     /region_name="ASKHA_NBD_Arp10"
                     /note="nucleotide-binding domain (NBD) of actin-related
                     protein 10 (Arp10) and similar proteins; cd10207"
                     /db_xref="CDD:466813"
     CDS             1..226
                     /gene="ACTR10"
                     /gene_synonym="ACTR11; Arp10; Arp11; HARP11"
                     /coded_by="XM_047431587.1:152..832"
                     /db_xref="GeneID:55860"
                     /db_xref="HGNC:HGNC:17372"
                     /db_xref="MIM:619731"
ORIGIN      
        1 mgsvpegvle dikgllfflk artcfvsdlk rglkiqaakf nidgnnerps pppnvdypld
       61 gekilhilgs irdsvveilf eqdneeqsva tlildsliqc pidtrkqlae nlvviggtsm
      121 lpgflhrlla eirylvekpk ykkalgtktf rihtppakan cvawlggaif galqdilgsr
      181 svskeyynqt gripdwcsln npplemmfdv gktqpplmkr afstek
//
LOCUS       XP_047287545             836 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase D1 isoform X1 [Homo sapiens].
ACCESSION   XP_047287545
VERSION     XP_047287545.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431589.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..836
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..836
                     /product="serine/threonine-protein kinase D1 isoform X1"
                     /calculated_mol_wt=94289
     Region          64..135
                     /region_name="C1_PKD1_rpt1"
                     /note="first protein kinase C conserved region 1 (C1
                     domain) found in protein kinase D (PKD) and similar
                     proteins; cd20839"
                     /db_xref="CDD:410389"
     Site            order(76..82,90..94,97)
                     /site_type="other"
                     /note="putative DAG/PE binding site [chemical binding]"
                     /db_xref="CDD:410389"
     Region          161..254
                     /region_name="C1_PKD1_rpt2"
                     /note="second protein kinase C conserved region 1 (C1
                     domain) found in protein kinase D (PKD) and similar
                     proteins; cd20842"
                     /db_xref="CDD:410392"
     Site            order(200..206,214..218,221)
                     /site_type="other"
                     /note="putative DAG/PE binding site [chemical binding]"
                     /db_xref="CDD:410392"
     Region          340..467
                     /region_name="PH_PKD"
                     /note="Protein kinase D (PKD/PKCmu) pleckstrin homology
                     (PH) domain; cd01239"
                     /db_xref="CDD:269945"
     Region          503..762
                     /region_name="STKc_PKD"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Protein Kinase D; cd14082"
                     /db_xref="CDD:270984"
     Site            order(513..517,521,534,536,567,583..586,589,591,629..630,
                     632,634..635,637,650..651,654,668..672,674)
                     /site_type="active"
                     /db_xref="CDD:270984"
     Site            order(513..516,521,534,536,567,583..586,589,634..635,637,
                     650..651)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270984"
     Site            order(517,589,591,629..630,632,634,654,668..672,674)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270984"
     Site            650..672
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270984"
     CDS             1..836
                     /gene="PRKD1"
                     /gene_synonym="CHDED; PKC-MU; PKCM; PKD; PRKCM"
                     /coded_by="XM_047431589.1:147..2657"
                     /db_xref="GeneID:5587"
                     /db_xref="HGNC:HGNC:9407"
                     /db_xref="MIM:605435"
ORIGIN      
        1 mwppsvveee imfpecgfyg mydkillfrh dptsenilql vkaasdiqeg dlievvlsas
       61 atfedfqirp halfvhsyra pafcdhcgem lwglvrqglk cegcglnyhk rcafkipnnc
      121 sgvrrrrlsn vsltgvstir tssaelstsa pdepllqksp sesfigrekr snsqsyigrp
      181 ihldkilmsk vkvphtfvih sytrptvcqy ckkllkglfr qglqckdcrf nchkrcapkv
      241 pnnclgevti ngdllspgae sdvvmeegsd dndsernsgl mddmeeamvq daemamaecq
      301 ndsgemqdpd pdhedanrti spstsnnipl mrvvqsvkht krksstvmke gwmvhytskd
      361 tlrkrhywrl dskcitlfqn dtgsryykei plseilslep vktsalipng anphcfeitt
      421 anvvyyvgen vvnpsspspn nsvltsgvga dvarmweiai qhalmpvipk gssvgtgtnl
      481 hrdisvsisv sncqiqenvd istvyqifpd evlgsgqfgi vyggkhrktg rdvaikiidk
      541 lrfptkqesq lrnevailqn lhhpgvvnle cmfetpervf vvmeklhgdm lemilssekg
      601 rlpehitkfl itqilvalrh lhfknivhcd lkpenvllas adpfpqvklc dfgfariige
      661 ksfrrsvvgt paylapevlr nkgynrsldm wsvgviiyvs lsgtfpfned edihdqiqna
      721 afmyppnpwk eisheaidli nnllqvkmrk rysvdktlsh pwlqdyqtwl dlreleckig
      781 eryithesdd lrwekyageq glqypthlin psashsdtpe teetemkalg ervsil
//
LOCUS       XP_011535267             824 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase D1 isoform X2 [Homo sapiens].
ACCESSION   XP_011535267
VERSION     XP_011535267.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536965.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..824
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..824
                     /product="serine/threonine-protein kinase D1 isoform X2"
                     /calculated_mol_wt=92760
     Region          44..115
                     /region_name="C1_PKD1_rpt1"
                     /note="first protein kinase C conserved region 1 (C1
                     domain) found in protein kinase D (PKD) and similar
                     proteins; cd20839"
                     /db_xref="CDD:410389"
     Site            order(56..62,70..74,77)
                     /site_type="other"
                     /note="putative DAG/PE binding site [chemical binding]"
                     /db_xref="CDD:410389"
     Region          149..242
                     /region_name="C1_PKD1_rpt2"
                     /note="second protein kinase C conserved region 1 (C1
                     domain) found in protein kinase D (PKD) and similar
                     proteins; cd20842"
                     /db_xref="CDD:410392"
     Site            order(188..194,202..206,209)
                     /site_type="other"
                     /note="putative DAG/PE binding site [chemical binding]"
                     /db_xref="CDD:410392"
     Region          328..455
                     /region_name="PH_PKD"
                     /note="Protein kinase D (PKD/PKCmu) pleckstrin homology
                     (PH) domain; cd01239"
                     /db_xref="CDD:269945"
     Region          491..750
                     /region_name="STKc_PKD"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Protein Kinase D; cd14082"
                     /db_xref="CDD:270984"
     Site            order(501..505,509,522,524,555,571..574,577,579,617..618,
                     620,622..623,625,638..639,642,656..660,662)
                     /site_type="active"
                     /db_xref="CDD:270984"
     Site            order(501..504,509,522,524,555,571..574,577,622..623,625,
                     638..639)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270984"
     Site            order(505,577,579,617..618,620,622,642,656..660,662)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270984"
     Site            638..660
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270984"
     CDS             1..824
                     /gene="PRKD1"
                     /gene_synonym="CHDED; PKC-MU; PKCM; PKD; PRKCM"
                     /coded_by="XM_011536965.3:8792..11266"
                     /db_xref="GeneID:5587"
                     /db_xref="HGNC:HGNC:9407"
                     /db_xref="MIM:605435"
ORIGIN      
        1 mydkillfrh dptsenilql vkaasdiqeg dlievvlsas atfedfqirp halfvhsyra
       61 pafcdhcgem lwglvrqglk cegcglnyhk rcafkipnnc sgvrrrrlsn vsltgvstir
      121 tssaelstsa pdepllspvs pgfeqkspse sfigrekrsn sqsyigrpih ldkilmskvk
      181 vphtfvihsy trptvcqyck kllkglfrqg lqckdcrfnc hkrcapkvpn nclgevting
      241 dllspgaesd vvmeegsddn dsernsglmd dmeeamvqda emamaecqnd sgemqdpdpd
      301 hedanrtisp stsnniplmr vvqsvkhtkr ksstvmkegw mvhytskdtl rkrhywrlds
      361 kcitlfqndt gsryykeipl seilslepvk tsalipngan phcfeittan vvyyvgenvv
      421 npsspspnns vltsgvgadv armweiaiqh almpvipkgs svgtgtnlhr disvsisvsn
      481 cqiqenvdis tvyqifpdev lgsgqfgivy ggkhrktgrd vaikiidklr fptkqesqlr
      541 nevailqnlh hpgvvnlecm fetpervfvv meklhgdmle milssekgrl pehitkflit
      601 qilvalrhlh fknivhcdlk penvllasad pfpqvklcdf gfariigeks frrsvvgtpa
      661 ylapevlrnk gynrsldmws vgviiyvsls gtfpfneded ihdqiqnaaf myppnpwkei
      721 sheaidlinn llqvkmrkry svdktlshpw lqdyqtwldl releckiger yithesddlr
      781 wekyageqgl qypthlinps ashsdtpete etemkalger vsil
//
LOCUS       XP_047287546             755 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase D1 isoform X3 [Homo sapiens].
ACCESSION   XP_047287546
VERSION     XP_047287546.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431590.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..755
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..755
                     /product="serine/threonine-protein kinase D1 isoform X3"
                     /calculated_mol_wt=84957
     Region          <1..46
                     /region_name="C1"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     superfamily; cl00040"
                     /db_xref="CDD:412127"
     Region          80..173
                     /region_name="C1_PKD1_rpt2"
                     /note="second protein kinase C conserved region 1 (C1
                     domain) found in protein kinase D (PKD) and similar
                     proteins; cd20842"
                     /db_xref="CDD:410392"
     Site            order(119..125,133..137,140)
                     /site_type="other"
                     /note="putative DAG/PE binding site [chemical binding]"
                     /db_xref="CDD:410392"
     Region          259..386
                     /region_name="PH_PKD"
                     /note="Protein kinase D (PKD/PKCmu) pleckstrin homology
                     (PH) domain; cd01239"
                     /db_xref="CDD:269945"
     Region          422..681
                     /region_name="STKc_PKD"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Protein Kinase D; cd14082"
                     /db_xref="CDD:270984"
     Site            order(432..436,440,453,455,486,502..505,508,510,548..549,
                     551,553..554,556,569..570,573,587..591,593)
                     /site_type="active"
                     /db_xref="CDD:270984"
     Site            order(432..435,440,453,455,486,502..505,508,553..554,556,
                     569..570)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270984"
     Site            order(436,508,510,548..549,551,553,573,587..591,593)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270984"
     Site            569..591
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270984"
     CDS             1..755
                     /gene="PRKD1"
                     /gene_synonym="CHDED; PKC-MU; PKCM; PKD; PRKCM"
                     /coded_by="XM_047431590.1:169..2436"
                     /db_xref="GeneID:5587"
                     /db_xref="HGNC:HGNC:9407"
                     /db_xref="MIM:605435"
ORIGIN      
        1 mlwglvrqgl kcegcglnyh krcafkipnn csgvrrrrls nvsltgvsti rtssaelsts
       61 apdepllspv spgfeqksps esfigrekrs nsqsyigrpi hldkilmskv kvphtfvihs
      121 ytrptvcqyc kkllkglfrq glqckdcrfn chkrcapkvp nnclgevtin gdllspgaes
      181 dvvmeegsdd ndsernsglm ddmeeamvqd aemamaecqn dsgemqdpdp dhedanrtis
      241 pstsnniplm rvvqsvkhtk rksstvmkeg wmvhytskdt lrkrhywrld skcitlfqnd
      301 tgsryykeip lseilslepv ktsalipnga nphcfeitta nvvyyvgenv vnpsspspnn
      361 svltsgvgad varmweiaiq halmpvipkg ssvgtgtnlh rdisvsisvs ncqiqenvdi
      421 stvyqifpde vlgsgqfgiv yggkhrktgr dvaikiidkl rfptkqesql rnevailqnl
      481 hhpgvvnlec mfetpervfv vmeklhgdml emilssekgr lpehitkfli tqilvalrhl
      541 hfknivhcdl kpenvllasa dpfpqvklcd fgfariigek sfrrsvvgtp aylapevlrn
      601 kgynrsldmw svgviiyvsl sgtfpfnede dihdqiqnaa fmyppnpwke isheaidlin
      661 nllqvkmrkr ysvdktlshp wlqdyqtwld lreleckige ryithesddl rwekyageqg
      721 lqypthlinp sashsdtpet eetemkalge rvsil
//
LOCUS       XP_005267917            2061 aa            linear   PRI 05-AUG-2025
DEFINITION  YLP motif-containing protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_005267917
VERSION     XP_005267917.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267860.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2061
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2061
                     /product="YLP motif-containing protein 1 isoform X1"
                     /calculated_mol_wt=231576
     Region          938..>1176
                     /region_name="PRK12678"
                     /note="transcription termination factor Rho; Provisional"
                     /db_xref="CDD:237171"
     Region          1085..>1327
                     /region_name="PRK12678"
                     /note="transcription termination factor Rho; Provisional"
                     /db_xref="CDD:237171"
     Region          1836..>1971
                     /region_name="AAA_33"
                     /note="AAA domain; pfam13671"
                     /db_xref="CDD:463952"
     CDS             1..2061
                     /gene="YLPM1"
                     /gene_synonym="C14orf170; PPP1R169; ZAP113; ZAP3"
                     /coded_by="XM_005267860.4:175..6360"
                     /db_xref="GeneID:56252"
                     /db_xref="HGNC:HGNC:17798"
                     /db_xref="MIM:619766"
ORIGIN      
        1 mypnwgrygg sshyppppvp ppppvalpea spgpgyssst tpaapsssgf msfreqhlaq
       61 lqqlqqmhqk qmqcvlqphh lpppplpppp vmpgggygdw qpppppmppp pgpalsyqkq
      121 qqykhqmlhh qrdgppglvp melesppesp pvppgsympp sqsympppqp ppsyypptss
      181 qpylppaqps psqsppsqsy laptpsysss ssssqsylsh sqsylpssqa spsrpsqghs
      241 ksqllapppp sappgnkttv qqeplesgak nksteqqqaa pepdpstmtp qeqqqywyrq
      301 hllslqqrtk vhlpghkkgp vvakdtpepv keevtvpats qvpespssee pplpppneev
      361 ppplppeepq sedpeedarl kqlqaaaahw qqhqqhrvgf qyqgimqkht qlqqilqqyq
      421 qiiqppphiq tmsvdmqlrh yemqqqqfqh lyqewerefq lweeqlhsyp hkdqlqeyek
      481 qwktwqghmk atqsylqekv nsfqnmknqy mgnmsmpppf vpysqmpppl ptmpppvlpp
      541 slpppvmppa lpatvpppgm pppvmppslp tsvpppgmpp slssagpppv lpppslssag
      601 pppvlpppsl sstapppvmp lpplssatpp pgipppgvpq gippqltaap vppasssqss
      661 qvpekprpal lptpvsfgsa ppttyhpplq sagpseqvns kaplsksalp yssfssdqgl
      721 gessaapsqp itavkdmpvr sggllpdppr ssylesprgp rfdgprrfed lgsrcegprp
      781 kgprfegnrp dgprpryegh paegtkskwg miprgpasqf yitpstslsp rqsgpqwkgp
      841 kpafgqqhqq qpksqaepls gnkepladts snqqknfkmq saafsiaadv kdvkaaqsne
      901 nlsdsqqepp ksevsegpve psnwdqnvqs metqidkaqa vtqpvplank pvpaqstfps
      961 ktggmeggta vatssltadn dfkpvgiglp hsennqdkgl prpdnrdnrl egnrgnsssy
     1021 rgpgqsrmed trdkglvnrg rgqaisrgpg lvkqedfrdk mmgrredsre kmnrgegsrd
     1081 rglvrpgssr ekvpgglqgs qdrgaagsre rgpprragsq ergplrrags reripprrag
     1141 srergpprgp gsrerglgrs dfgrdrgpfr pepgdggekm ypyhrdeppr apwnhgeerg
     1201 heefpldgrn apmererldd wdrerywrec erdyqddtle lynredrfsa ppsrshdgdr
     1261 rgpwwddwer dqdmdedynr emerdmdrdv drisrpmdmy drsldnewdr dygrpldeqe
     1321 sqfrerdips lpplpplppl ppldryrddr wreernrehg ydrdfrdrge lrireyperg
     1381 dtwrekrdyv pdrmdwerer lsdrwypsdv drhspmaehm psshhssemm gsdasldsdq
     1441 glggvmvlsq rqheiilkaa qelkmlreqk eqlqkmkdfg sepqmadhlp pqesrlqnts
     1501 srpgmypppg syrppppmgk ppgsivrpsa pparssvpvt rppvpipppp pppplppppp
     1561 vikpqtsave qerwdedsfy glwdtndeqg lnsefkseta aipsapvlpp ppvhssippp
     1621 gpvpmgmppm skpppvqqtv dyghgrdist nkveqipyge ritlrpdplp erstfeteha
     1681 gqrdrydrer drepyfdrqs nviadhrdfk rdrethrdrd rdrgvidydr drfdrerrpr
     1741 ddraqsyrdk kdhsssrrgg fdrpsydrks drpvyegpsm fggerrtype ermplpapsl
     1801 shqpppaprv ekkpesknvd dilkppgres rperivvimr glpgsgkthv aklirdkeve
     1861 fggpaprvls lddyfiteve keekdpdsgk kvkkkvmeye yeaemeetyr tsmfktfkkt
     1921 lddgffpfii ldaindrvrh fdqfwsaakt kgfevylaem sadnqtcgkr nihgrklkei
     1981 nkmadhweta prhmmrldir sllqdaaiee vemedfdani eeqkeekkda eeeeselgyi
     2041 pkskwemdts eaklvchvee v
//
LOCUS       XP_047287547            2042 aa            linear   PRI 05-AUG-2025
DEFINITION  YLP motif-containing protein 1 isoform X2 [Homo sapiens].
ACCESSION   XP_047287547
VERSION     XP_047287547.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431591.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2042
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2042
                     /product="YLP motif-containing protein 1 isoform X2"
                     /calculated_mol_wt=229392
     Region          938..>1176
                     /region_name="PRK12678"
                     /note="transcription termination factor Rho; Provisional"
                     /db_xref="CDD:237171"
     Region          1085..>1327
                     /region_name="PRK12678"
                     /note="transcription termination factor Rho; Provisional"
                     /db_xref="CDD:237171"
     Region          1836..>1971
                     /region_name="AAA_33"
                     /note="AAA domain; pfam13671"
                     /db_xref="CDD:463952"
     CDS             1..2042
                     /gene="YLPM1"
                     /gene_synonym="C14orf170; PPP1R169; ZAP113; ZAP3"
                     /coded_by="XM_047431591.1:175..6303"
                     /db_xref="GeneID:56252"
                     /db_xref="HGNC:HGNC:17798"
                     /db_xref="MIM:619766"
ORIGIN      
        1 mypnwgrygg sshyppppvp ppppvalpea spgpgyssst tpaapsssgf msfreqhlaq
       61 lqqlqqmhqk qmqcvlqphh lpppplpppp vmpgggygdw qpppppmppp pgpalsyqkq
      121 qqykhqmlhh qrdgppglvp melesppesp pvppgsympp sqsympppqp ppsyypptss
      181 qpylppaqps psqsppsqsy laptpsysss ssssqsylsh sqsylpssqa spsrpsqghs
      241 ksqllapppp sappgnkttv qqeplesgak nksteqqqaa pepdpstmtp qeqqqywyrq
      301 hllslqqrtk vhlpghkkgp vvakdtpepv keevtvpats qvpespssee pplpppneev
      361 ppplppeepq sedpeedarl kqlqaaaahw qqhqqhrvgf qyqgimqkht qlqqilqqyq
      421 qiiqppphiq tmsvdmqlrh yemqqqqfqh lyqewerefq lweeqlhsyp hkdqlqeyek
      481 qwktwqghmk atqsylqekv nsfqnmknqy mgnmsmpppf vpysqmpppl ptmpppvlpp
      541 slpppvmppa lpatvpppgm pppvmppslp tsvpppgmpp slssagpppv lpppslssag
      601 pppvlpppsl sstapppvmp lpplssatpp pgipppgvpq gippqltaap vppasssqss
      661 qvpekprpal lptpvsfgsa ppttyhpplq sagpseqvns kaplsksalp yssfssdqgl
      721 gessaapsqp itavkdmpvr sggllpdppr ssylesprgp rfdgprrfed lgsrcegprp
      781 kgprfegnrp dgprpryegh paegtkskwg miprgpasqf yitpstslsp rqsgpqwkgp
      841 kpafgqqhqq qpksqaepls gnkepladts snqqknfkmq saafsiaadv kdvkaaqsne
      901 nlsdsqqepp ksevsegpve psnwdqnvqs metqidkaqa vtqpvplank pvpaqstfps
      961 ktggmeggta vatssltadn dfkpvgiglp hsennqdkgl prpdnrdnrl egnrgnsssy
     1021 rgpgqsrmed trdkglvnrg rgqaisrgpg lvkqedfrdk mmgrredsre kmnrgegsrd
     1081 rglvrpgssr ekvpgglqgs qdrgaagsre rgpprragsq ergplrrags reripprrag
     1141 srergpprgp gsrerglgrs dfgrdrgpfr pepgdggekm ypyhrdeppr apwnhgeerg
     1201 heefpldgrn apmererldd wdrerywrec erdyqddtle lynredrfsa ppsrshdgdr
     1261 rgpwwddwer dqdmdedynr emerdmdrdv drisrpmdmy drsldnewdr dygrpldeqe
     1321 sqfrerdips lpplpplppl ppldryrddr wreernrehg ydrdfrdrge lrireyperg
     1381 dtwrekrdyv pdrmdwerer lsdrwypsdv drhspmaehm psshhssemm gsdasldsdq
     1441 glggvmvlsq rqheiilkaa qelkmlreqk eqlqkmkdfg sepqmadhlp pqesrlqnts
     1501 srpgmypppg syrppppmgk ppgsivrpsa pparssvpvt rppvpipppp pppplppppp
     1561 vikpqtsave qerwdedsfy glwdtndeqg lnsefkseta aipsapvlpp ppvhssippp
     1621 gpvpmgmppm skpppvqqtv dyghgrdist nkveqipyge ritlrpdplp erstfeteha
     1681 gqrdrydrer drepyfdrqs nviadhrdfk rdrethrdrd rdrgvidydr drfdrerrpr
     1741 ddraqsyrdk kdhsssrrgg fdrpsydrks drpvyegpsm fggerrtype ermplpapsl
     1801 shqpppaprv ekkpesknvd dilkppgres rperivvimr glpgsgkthv aklirdkeve
     1861 fggpaprvls lddyfiteve keekdpdsgk kvkkkvmeye yeaemeetyr tsmfktfkkt
     1921 lddgffpfii ldaindrvrh fdqfwsaakt kgfevylaem sadnqtcgkr nihgrklkei
     1981 nkmadhweta prhmmrldir sllqdaaiee vemedfdani eeqkeekkda eeeeseltsw
     2041 ma
//
LOCUS       XP_011535268            1741 aa            linear   PRI 05-AUG-2025
DEFINITION  YLP motif-containing protein 1 isoform X3 [Homo sapiens].
ACCESSION   XP_011535268
VERSION     XP_011535268.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536966.3
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 18% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1741
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1741
                     /product="YLP motif-containing protein 1 isoform X3"
                     /calculated_mol_wt=197464
     Region          533..>771
                     /region_name="PRK12678"
                     /note="transcription termination factor Rho; Provisional"
                     /db_xref="CDD:237171"
     Region          680..>922
                     /region_name="PRK12678"
                     /note="transcription termination factor Rho; Provisional"
                     /db_xref="CDD:237171"
     Region          1431..>1566
                     /region_name="AAA_33"
                     /note="AAA domain; pfam13671"
                     /db_xref="CDD:463952"
     CDS             1..1741
                     /gene="YLPM1"
                     /gene_synonym="C14orf170; PPP1R169; ZAP113; ZAP3"
                     /coded_by="XM_011536966.3:1445..6670"
                     /db_xref="GeneID:56252"
                     /db_xref="HGNC:HGNC:17798"
                     /db_xref="MIM:619766"
ORIGIN      
        1 mqkhtqlqqi lqqyqqiiqp pphiqtmsvd mqlrhyemqq qqfqhlyqew erefqlweeq
       61 lhsyphkdql qeyekqwktw qghmkatqsy lqekvnsfqn mknqymgnms mpppfvpysq
      121 mppplptmpp pvlppslppp vmppalpatv pppgmpppvm ppslptsvpp pgmppslssa
      181 gpppvlppps lssagpppvl pppslsstap ppvmplppls satpppgipp pgvpqgippq
      241 ltaapvppas ssqssqvpek prpallptpv sfgsapptty hpplqsagps eqvnskapls
      301 ksalpyssfs sdqglgessa apsqpitavk dmpvrsggll pdpprssyle sprgprfdgp
      361 rrfedlgsrc egprpkgprf egnrpdgprp ryeghpaegt kskwgmiprg pasqfyitps
      421 tslsprqsgp qwkgpkpafg qqhqqqpksq aeplsgnkep ladtssnqqk nfkmqsaafs
      481 iaadvkdvka aqsnenlsds qqeppksevs egpvepsnwd qnvqsmetqi dkaqavtqpv
      541 plankpvpaq stfpsktggm eggtavatss ltadndfkpv giglphsenn qdkglprpdn
      601 rdnrlegnrg nsssyrgpgq srmedtrdkg lvnrgrgqai srgpglvkqe dfrdkmmgrr
      661 edsrekmnrg egsrdrglvr pgssrekvpg glqgsqdrga agsrergppr ragsqergpl
      721 rragsrerip prragsrerg pprgpgsrer glgrsdfgrd rgpfrpepgd ggekmypyhr
      781 depprapwnh geergheefp ldgrnapmer erlddwdrer ywrecerdyq ddtlelynre
      841 drfsappsrs hdgdrrgpww ddwerdqdmd edynremerd mdrdvdrisr pmdmydrsld
      901 newdrdygrp ldeqesqfre rdipslpplp plpplppldr yrddrwreer nrehgydrdf
      961 rdrgelrire ypergdtwre krdyvpdrmd wererlsdrw ypsdvdrhsp maehmpsshh
     1021 ssemmgsdas ldsdqglggv mvlsqrqhei ilkaaqelkm lreqkeqlqk mkdfgsepqm
     1081 adhlppqesr lqntssrpgm ypppgsyrpp ppmgkppgsi vrpsappars svpvtrppvp
     1141 ippppppppl pppppvikpq tsaveqerwd edsfyglwdt ndeqglnsef ksetaaipsa
     1201 pvlppppvhs sipppgpvpm gmppmskppp vqqtvdyghg rdistnkveq ipygeritlr
     1261 pdplperstf etehagqrdr ydrerdrepy fdrqsnviad hrdfkrdret hrdrdrdrgv
     1321 idydrdrfdr errprddraq syrdkkdhss srrggfdrps ydrksdrpvy egpsmfgger
     1381 rtypeermpl papslshqpp paprvekkpe sknvddilkp pgresrperi vvimrglpgs
     1441 gkthvaklir dkevefggpa prvlslddyf itevekeekd pdsgkkvkkk vmeyeyeaem
     1501 eetyrtsmfk tfkktlddgf fpfiildain drvrhfdqfw saaktkgfev ylaemsadnq
     1561 tcgkrnihgr klkeinkmad hwetaprhmm rldirsllqd aaieevemed fdanieeqke
     1621 ekkdaeeees elgyipkskw emdtseakld kldglrtgtk rkrdweaias rmedylqlpd
     1681 dydtrasepg kkrvrwadle ekkdadrkra igfvvgqtdw ekitdesghl aekalnrtky
     1741 i
//
LOCUS       XP_047287548            1355 aa            linear   PRI 05-AUG-2025
DEFINITION  YLP motif-containing protein 1 isoform X4 [Homo sapiens].
ACCESSION   XP_047287548
VERSION     XP_047287548.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431592.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1355
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1355
                     /product="YLP motif-containing protein 1 isoform X4"
                     /calculated_mol_wt=150672
     Region          1130..>1265
                     /region_name="AAA_33"
                     /note="AAA domain; pfam13671"
                     /db_xref="CDD:463952"
     CDS             1..1355
                     /gene="YLPM1"
                     /gene_synonym="C14orf170; PPP1R169; ZAP113; ZAP3"
                     /coded_by="XM_047431592.1:175..4242"
                     /db_xref="GeneID:56252"
                     /db_xref="HGNC:HGNC:17798"
                     /db_xref="MIM:619766"
ORIGIN      
        1 mypnwgrygg sshyppppvp ppppvalpea spgpgyssst tpaapsssgf msfreqhlaq
       61 lqqlqqmhqk qmqcvlqphh lpppplpppp vmpgggygdw qpppppmppp pgpalsyqkq
      121 qqykhqmlhh qrdgppglvp melesppesp pvppgsympp sqsympppqp ppsyypptss
      181 qpylppaqps psqsppsqsy laptpsysss ssssqsylsh sqsylpssqa spsrpsqghs
      241 ksqllapppp sappgnkttv qqeplesgak nksteqqqaa pepdpstmtp qeqqqywyrq
      301 hllslqqrtk vhlpghkkgp vvakdtpepv keevtvpats qvpespssee pplpppneev
      361 ppplppeepq sedpeedarl kqlqaaaahw qqhqqhrvgf qyqgimqkht qlqqilqqyq
      421 qiiqppphiq tmsvdmqlrh yemqqqqfqh lyqewerefq lweeqlhsyp hkdqlqeyek
      481 qwktwqghmk atqsylqekv nsfqnmknqy mgnmsmpppf vpysqmpppl ptmpppvlpp
      541 slpppvmppa lpatvpppgm pppvmppslp tsvpppgmpp slssagpppv lpppslssag
      601 pppvlpppsl sstapppvmp lpplssatpp pgipppgvpq gippqltaap vppasssqss
      661 qvpekprpal lptpvsfgsa ppttyhpplq sagpseqvns kaplsksalp yssfssdqgl
      721 gessaapsqp itavkdmpvr sggllpdppr ssylesprgp reqkeqlqkm kdfgsepqma
      781 dhlppqesrl qntssrpgmy pppgsyrppp pmgkppgsiv rpsapparss vpvtrppvpi
      841 pppppppplp ppppvikpqt saveqerwde dsfyglwdtn deqglnsefk setaaipsap
      901 vlppppvhss ipppgpvpmg mppmskpppv qqtvdyghgr distnkveqi pygeritlrp
      961 dplperstfe tehagqrdry drerdrepyf drqsnviadh rdfkrdreth rdrdrdrgvi
     1021 dydrdrfdre rrprddraqs yrdkkdhsss rrggfdrpsy drksdrpvye gpsmfggerr
     1081 typeermplp apslshqppp aprvekkpes knvddilkpp gresrperiv vimrglpgsg
     1141 kthvaklird kevefggpap rvlslddyfi tevekeekdp dsgkkvkkkv meyeyeaeme
     1201 etyrtsmfkt fkktlddgff pfiildaind rvrhfdqfws aaktkgfevy laemsadnqt
     1261 cgkrnihgrk lkeinkmadh wetaprhmmr ldirsllqda aieevemedf danieeqkee
     1321 kkdaeeeese lgyipkskwe mdtseaklvc hveev
//
LOCUS       XP_011535270             558 aa            linear   PRI 05-AUG-2025
DEFINITION  N(6)-adenosine-methyltransferase catalytic subunit METTL3 isoform
            X1 [Homo sapiens].
ACCESSION   XP_011535270
VERSION     XP_011535270.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536968.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..558
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..558
                     /product="N(6)-adenosine-methyltransferase catalytic
                     subunit METTL3 isoform X1"
                     /calculated_mol_wt=62102
     Region          389..528
                     /region_name="MT-A70"
                     /note="cl01947"
                     /db_xref="CDD:470404"
     CDS             1..558
                     /gene="METTL3"
                     /gene_synonym="hMETTL3; IME4; M6A; MT-A70; Spo8"
                     /coded_by="XM_011536968.3:118..1794"
                     /db_xref="GeneID:56339"
                     /db_xref="HGNC:HGNC:17563"
                     /db_xref="MIM:612472"
ORIGIN      
        1 msdtwssiqa hkkqldslre rlqrrrkqds ghldlrnpea alsptfrsds pvptaptsgg
       61 pkpstasavp elatdpelek kllhhlsdla ltlptdavsi claistpdap atqdgvesll
      121 qkfaaqelie vkrgllqdda hptlvtyadh sklsammgav aekkgpgeva gtvtgqkrra
      181 eqdsttvaaf asslvsglns sasepakepa kksrkhaasd vdleieslln qqstkeqqsk
      241 kvsqeilell ntttakeqsi vekfrsrgra qvqefcdygt keecmkasda drpcrklhfr
      301 riinkhtdes lgdcsflntc fhmdtckyvh yeidacmdse apgskdhtps qelaltqsvg
      361 gdssadrlfp pqwiccdiry ldvsilgkfa vvmadppwdi hmelpygtlt ddemrrlnip
      421 vlqddgflfl wvtgramelg reclnlwgye rvdeiiwvkt nqlqriirtg rtghwlnhgk
      481 ehclvrstsh kpdeiygmie rlspgtrkie lfgrphnvqp nwitlgnqld gihlldpdvv
      541 arfkqrypdg iiskpknl
//
LOCUS       XP_047287550             305 aa            linear   PRI 05-AUG-2025
DEFINITION  N(6)-adenosine-methyltransferase catalytic subunit METTL3 isoform
            X2 [Homo sapiens].
ACCESSION   XP_047287550
VERSION     XP_047287550.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431594.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..305
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..305
                     /product="N(6)-adenosine-methyltransferase catalytic
                     subunit METTL3 isoform X2"
                     /calculated_mol_wt=33032
     CDS             1..305
                     /gene="METTL3"
                     /gene_synonym="hMETTL3; IME4; M6A; MT-A70; Spo8"
                     /coded_by="XM_047431594.1:118..1035"
                     /db_xref="GeneID:56339"
                     /db_xref="HGNC:HGNC:17563"
                     /db_xref="MIM:612472"
ORIGIN      
        1 msdtwssiqa hkkqldslre rlqrrrkqds ghldlrnpea alsptfrsds pvptaptsgg
       61 pkpstasavp elatdpelek kllhhlsdla ltlptdavsi claistpdap atqdgvesll
      121 qkfaaqelie vkrgllqdda hptlvtyadh sklsammgav aekkgpgeva gtvtgqkrra
      181 eqdsttvaaf asslvsglns sasepakepa kksrkhaasd vdleieslln qqstkeqqsk
      241 kvsqeilell ntttakeqsi vekfrsrgra qvqefcdygt keecmkasda drpcrklhfr
      301 slgre
//
LOCUS       XP_006720269             296 aa            linear   PRI 05-AUG-2025
DEFINITION  N(6)-adenosine-methyltransferase catalytic subunit METTL3 isoform
            X3 [Homo sapiens].
ACCESSION   XP_006720269
VERSION     XP_006720269.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720206.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..296
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..296
                     /product="N(6)-adenosine-methyltransferase catalytic
                     subunit METTL3 isoform X3"
                     /calculated_mol_wt=33654
     Region          105..266
                     /region_name="MT-A70"
                     /note="pfam05063"
                     /db_xref="CDD:368270"
     CDS             1..296
                     /gene="METTL3"
                     /gene_synonym="hMETTL3; IME4; M6A; MT-A70; Spo8"
                     /coded_by="XM_006720206.5:135..1025"
                     /db_xref="GeneID:56339"
                     /db_xref="HGNC:HGNC:17563"
                     /db_xref="MIM:612472"
ORIGIN      
        1 mkasdadrpc rklhfrriin khtdeslgdc sflntcfhmd tckyvhyeid acmdseapgs
       61 kdhtpsqela ltqsvggdss adrlfppqwi ccdiryldvs ilgkfavvma dppwdihmel
      121 pygtltddem rrlnipvlqd dgflflwvtg ramelgrecl nlwgyervde iiwvktnqlq
      181 riirtgrtgh wlnhgkehcl vgvkgnpqgf nqgldcdviv aevrstshkp deiygmierl
      241 spgtrkielf grphnvqpnw itlgnqldgi hlldpdvvar fkqrypdgii skpknl
//
LOCUS       XP_047287551             433 aa            linear   PRI 05-AUG-2025
DEFINITION  legumain isoform X1 [Homo sapiens].
ACCESSION   XP_047287551
VERSION     XP_047287551.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431595.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..433
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..433
                     /product="legumain isoform X1"
                     /calculated_mol_wt=49280
     Region          29..285
                     /region_name="Peptidase_C13"
                     /note="Peptidase C13 family; pfam01650"
                     /db_xref="CDD:396290"
     Region          309..429
                     /region_name="legumain_C"
                     /note="C-terminal prodomain of legumain; cd21115"
                     /db_xref="CDD:411051"
     Site            order(310..311,313..315,317..318,321,370,376..377,
                     379..380,383,387,393,399,402..403,405..406)
                     /site_type="other"
                     /note="catalytic domain interface [polypeptide binding]"
                     /db_xref="CDD:411051"
     CDS             1..433
                     /gene="LGMN"
                     /gene_synonym="AEP; LGMN1; PRSC1"
                     /coded_by="XM_047431595.1:147..1448"
                     /db_xref="GeneID:5641"
                     /db_xref="HGNC:HGNC:9472"
                     /db_xref="MIM:602620"
ORIGIN      
        1 mvwkvavfls valgigavpi ddpedggkhw vvivagsngw ynyrhqadac hayqiihrng
       61 ipdeqivvmm yddiaysedn ptpgivinrp ngtdvyqgvp kdytgedvtp qnflavlrgd
      121 aeavkgigsg kvlksgpqdh vfiyftdhgs tgilvfpned lhvkdlneti hymykhkmyr
      181 kmvfyieace sgsmmnhlpd ninvyattaa npressyacy ydekrstylg dwysvnwmed
      241 sdvedltket lhkqyhlvks htntshvmqy gnktistmkv mqfqgmkrka sspvplppvt
      301 hldltpspdv pltimkrklm ntndleesrq lteeiqrhld arhlieksvr kivsllaase
      361 aeveqllser apltghscyp eallhfrthc fnwhsptyey alrhlyvlvn lcekpyplhr
      421 iklsmdhvcl ghy
//
LOCUS       XP_016876952             433 aa            linear   PRI 05-AUG-2025
DEFINITION  legumain isoform X1 [Homo sapiens].
ACCESSION   XP_016876952
VERSION     XP_016876952.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021463.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..433
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..433
                     /product="legumain isoform X1"
                     /calculated_mol_wt=49280
     Region          29..285
                     /region_name="Peptidase_C13"
                     /note="Peptidase C13 family; pfam01650"
                     /db_xref="CDD:396290"
     Region          309..429
                     /region_name="legumain_C"
                     /note="C-terminal prodomain of legumain; cd21115"
                     /db_xref="CDD:411051"
     Site            order(310..311,313..315,317..318,321,370,376..377,
                     379..380,383,387,393,399,402..403,405..406)
                     /site_type="other"
                     /note="catalytic domain interface [polypeptide binding]"
                     /db_xref="CDD:411051"
     CDS             1..433
                     /gene="LGMN"
                     /gene_synonym="AEP; LGMN1; PRSC1"
                     /coded_by="XM_017021463.2:48..1349"
                     /db_xref="GeneID:5641"
                     /db_xref="HGNC:HGNC:9472"
                     /db_xref="MIM:602620"
ORIGIN      
        1 mvwkvavfls valgigavpi ddpedggkhw vvivagsngw ynyrhqadac hayqiihrng
       61 ipdeqivvmm yddiaysedn ptpgivinrp ngtdvyqgvp kdytgedvtp qnflavlrgd
      121 aeavkgigsg kvlksgpqdh vfiyftdhgs tgilvfpned lhvkdlneti hymykhkmyr
      181 kmvfyieace sgsmmnhlpd ninvyattaa npressyacy ydekrstylg dwysvnwmed
      241 sdvedltket lhkqyhlvks htntshvmqy gnktistmkv mqfqgmkrka sspvplppvt
      301 hldltpspdv pltimkrklm ntndleesrq lteeiqrhld arhlieksvr kivsllaase
      361 aeveqllser apltghscyp eallhfrthc fnwhsptyey alrhlyvlvn lcekpyplhr
      421 iklsmdhvcl ghy
//
LOCUS       XP_047287553             433 aa            linear   PRI 05-AUG-2025
DEFINITION  legumain isoform X1 [Homo sapiens].
ACCESSION   XP_047287553
VERSION     XP_047287553.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431597.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..433
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..433
                     /product="legumain isoform X1"
                     /calculated_mol_wt=49280
     Region          29..285
                     /region_name="Peptidase_C13"
                     /note="Peptidase C13 family; pfam01650"
                     /db_xref="CDD:396290"
     Region          309..429
                     /region_name="legumain_C"
                     /note="C-terminal prodomain of legumain; cd21115"
                     /db_xref="CDD:411051"
     Site            order(310..311,313..315,317..318,321,370,376..377,
                     379..380,383,387,393,399,402..403,405..406)
                     /site_type="other"
                     /note="catalytic domain interface [polypeptide binding]"
                     /db_xref="CDD:411051"
     CDS             1..433
                     /gene="LGMN"
                     /gene_synonym="AEP; LGMN1; PRSC1"
                     /coded_by="XM_047431597.1:147..1448"
                     /db_xref="GeneID:5641"
                     /db_xref="HGNC:HGNC:9472"
                     /db_xref="MIM:602620"
ORIGIN      
        1 mvwkvavfls valgigavpi ddpedggkhw vvivagsngw ynyrhqadac hayqiihrng
       61 ipdeqivvmm yddiaysedn ptpgivinrp ngtdvyqgvp kdytgedvtp qnflavlrgd
      121 aeavkgigsg kvlksgpqdh vfiyftdhgs tgilvfpned lhvkdlneti hymykhkmyr
      181 kmvfyieace sgsmmnhlpd ninvyattaa npressyacy ydekrstylg dwysvnwmed
      241 sdvedltket lhkqyhlvks htntshvmqy gnktistmkv mqfqgmkrka sspvplppvt
      301 hldltpspdv pltimkrklm ntndleesrq lteeiqrhld arhlieksvr kivsllaase
      361 aeveqllser apltghscyp eallhfrthc fnwhsptyey alrhlyvlvn lcekpyplhr
      421 iklsmdhvcl ghy
//
LOCUS       XP_047287554             429 aa            linear   PRI 05-AUG-2025
DEFINITION  legumain isoform X2 [Homo sapiens].
ACCESSION   XP_047287554
VERSION     XP_047287554.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431598.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..429
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..429
                     /product="legumain isoform X2"
                     /calculated_mol_wt=48340
     Region          29..285
                     /region_name="Peptidase_C13"
                     /note="Peptidase C13 family; pfam01650"
                     /db_xref="CDD:396290"
     Region          309..>394
                     /region_name="legumain_C"
                     /note="C-terminal prodomain of legumain; cd21115"
                     /db_xref="CDD:411051"
     CDS             1..429
                     /gene="LGMN"
                     /gene_synonym="AEP; LGMN1; PRSC1"
                     /coded_by="XM_047431598.1:148..1437"
                     /db_xref="GeneID:5641"
                     /db_xref="HGNC:HGNC:9472"
                     /db_xref="MIM:602620"
ORIGIN      
        1 mvwkvavfls valgigavpi ddpedggkhw vvivagsngw ynyrhqadac hayqiihrng
       61 ipdeqivvmm yddiaysedn ptpgivinrp ngtdvyqgvp kdytgedvtp qnflavlrgd
      121 aeavkgigsg kvlksgpqdh vfiyftdhgs tgilvfpned lhvkdlneti hymykhkmyr
      181 kmvfyieace sgsmmnhlpd ninvyattaa npressyacy ydekrstylg dwysvnwmed
      241 sdvedltket lhkqyhlvks htntshvmqy gnktistmkv mqfqgmkrka sspvplppvt
      301 hldltpspdv pltimkrklm ntndleesrq lteeiqrhld arhlieksvr kivsllaase
      361 aeveqllser apltghscyp eallhfrthc fnwhsptdki vhgprvpwsl lksclleafp
      421 svsapptvc
//
LOCUS       XP_005267921             467 aa            linear   PRI 05-AUG-2025
DEFINITION  presenilin-1 isoform X1 [Homo sapiens].
ACCESSION   XP_005267921
VERSION     XP_005267921.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267864.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..467
                     /product="presenilin-1 isoform X1"
                     /calculated_mol_wt=52537
     Region          76..457
                     /region_name="Presenilin"
                     /note="pfam01080"
                     /db_xref="CDD:460052"
     CDS             1..467
                     /gene="PSEN1"
                     /gene_synonym="ACNINV3; AD3; CMD1U; FAD; PS-1; PS1; PSNL1;
                     S182"
                     /coded_by="XM_005267864.4:209..1612"
                     /db_xref="GeneID:5663"
                     /db_xref="HGNC:HGNC:9508"
                     /db_xref="MIM:104311"
ORIGIN      
        1 mtelpaplsy fqnaqmsedn hlsntvrsqn dnrerqehnd rrslghpepl sngrpqgnsr
       61 qvveqdeeed eeltlkygak hvimlfvpvt lcmvvvvati ksvsfytrkd gqliytpfte
      121 dtetvgqral hsilnaaimi svivvmtill vvlykyrcyk vihawliiss llllfffsfi
      181 ylgevfktyn vavdyitval liwnfgvvgm isihwkgplr lqqaylimis almalvfiky
      241 lpewtawlil avisvydlva vlcpkgplrm lvetaqerne tlfpaliyss tmvwlvnmae
      301 gdpeaqrrvs knskynaest eresqdtvae nddggfseew eaqrdshlgp hrstpesraa
      361 vqelsssila gedpeergvk lglgdfifys vlvgkasata sgdwnttiac fvailiglcl
      421 tllllaifkk alpalpisit fglvfyfatd ylvqpfmdql afhqfyi
//
LOCUS       XP_047287556             467 aa            linear   PRI 05-AUG-2025
DEFINITION  presenilin-1 isoform X1 [Homo sapiens].
ACCESSION   XP_047287556
VERSION     XP_047287556.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431600.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..467
                     /product="presenilin-1 isoform X1"
                     /calculated_mol_wt=52537
     Region          76..457
                     /region_name="Presenilin"
                     /note="pfam01080"
                     /db_xref="CDD:460052"
     CDS             1..467
                     /gene="PSEN1"
                     /gene_synonym="ACNINV3; AD3; CMD1U; FAD; PS-1; PS1; PSNL1;
                     S182"
                     /coded_by="XM_047431600.1:1782..3185"
                     /db_xref="GeneID:5663"
                     /db_xref="HGNC:HGNC:9508"
                     /db_xref="MIM:104311"
ORIGIN      
        1 mtelpaplsy fqnaqmsedn hlsntvrsqn dnrerqehnd rrslghpepl sngrpqgnsr
       61 qvveqdeeed eeltlkygak hvimlfvpvt lcmvvvvati ksvsfytrkd gqliytpfte
      121 dtetvgqral hsilnaaimi svivvmtill vvlykyrcyk vihawliiss llllfffsfi
      181 ylgevfktyn vavdyitval liwnfgvvgm isihwkgplr lqqaylimis almalvfiky
      241 lpewtawlil avisvydlva vlcpkgplrm lvetaqerne tlfpaliyss tmvwlvnmae
      301 gdpeaqrrvs knskynaest eresqdtvae nddggfseew eaqrdshlgp hrstpesraa
      361 vqelsssila gedpeergvk lglgdfifys vlvgkasata sgdwnttiac fvailiglcl
      421 tllllaifkk alpalpisit fglvfyfatd ylvqpfmdql afhqfyi
//
LOCUS       XP_047287557             467 aa            linear   PRI 05-AUG-2025
DEFINITION  presenilin-1 isoform X1 [Homo sapiens].
ACCESSION   XP_047287557
VERSION     XP_047287557.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431601.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..467
                     /product="presenilin-1 isoform X1"
                     /calculated_mol_wt=52537
     Region          76..457
                     /region_name="Presenilin"
                     /note="pfam01080"
                     /db_xref="CDD:460052"
     CDS             1..467
                     /gene="PSEN1"
                     /gene_synonym="ACNINV3; AD3; CMD1U; FAD; PS-1; PS1; PSNL1;
                     S182"
                     /coded_by="XM_047431601.1:165..1568"
                     /db_xref="GeneID:5663"
                     /db_xref="HGNC:HGNC:9508"
                     /db_xref="MIM:104311"
ORIGIN      
        1 mtelpaplsy fqnaqmsedn hlsntvrsqn dnrerqehnd rrslghpepl sngrpqgnsr
       61 qvveqdeeed eeltlkygak hvimlfvpvt lcmvvvvati ksvsfytrkd gqliytpfte
      121 dtetvgqral hsilnaaimi svivvmtill vvlykyrcyk vihawliiss llllfffsfi
      181 ylgevfktyn vavdyitval liwnfgvvgm isihwkgplr lqqaylimis almalvfiky
      241 lpewtawlil avisvydlva vlcpkgplrm lvetaqerne tlfpaliyss tmvwlvnmae
      301 gdpeaqrrvs knskynaest eresqdtvae nddggfseew eaqrdshlgp hrstpesraa
      361 vqelsssila gedpeergvk lglgdfifys vlvgkasata sgdwnttiac fvailiglcl
      421 tllllaifkk alpalpisit fglvfyfatd ylvqpfmdql afhqfyi
//
LOCUS       XP_011535274             467 aa            linear   PRI 05-AUG-2025
DEFINITION  presenilin-1 isoform X1 [Homo sapiens].
ACCESSION   XP_011535274
VERSION     XP_011535274.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536972.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..467
                     /product="presenilin-1 isoform X1"
                     /calculated_mol_wt=52537
     Region          76..457
                     /region_name="Presenilin"
                     /note="pfam01080"
                     /db_xref="CDD:460052"
     CDS             1..467
                     /gene="PSEN1"
                     /gene_synonym="ACNINV3; AD3; CMD1U; FAD; PS-1; PS1; PSNL1;
                     S182"
                     /coded_by="XM_011536972.3:853..2256"
                     /db_xref="GeneID:5663"
                     /db_xref="HGNC:HGNC:9508"
                     /db_xref="MIM:104311"
ORIGIN      
        1 mtelpaplsy fqnaqmsedn hlsntvrsqn dnrerqehnd rrslghpepl sngrpqgnsr
       61 qvveqdeeed eeltlkygak hvimlfvpvt lcmvvvvati ksvsfytrkd gqliytpfte
      121 dtetvgqral hsilnaaimi svivvmtill vvlykyrcyk vihawliiss llllfffsfi
      181 ylgevfktyn vavdyitval liwnfgvvgm isihwkgplr lqqaylimis almalvfiky
      241 lpewtawlil avisvydlva vlcpkgplrm lvetaqerne tlfpaliyss tmvwlvnmae
      301 gdpeaqrrvs knskynaest eresqdtvae nddggfseew eaqrdshlgp hrstpesraa
      361 vqelsssila gedpeergvk lglgdfifys vlvgkasata sgdwnttiac fvailiglcl
      421 tllllaifkk alpalpisit fglvfyfatd ylvqpfmdql afhqfyi
//
LOCUS       XP_005267923             463 aa            linear   PRI 05-AUG-2025
DEFINITION  presenilin-1 isoform X2 [Homo sapiens].
ACCESSION   XP_005267923
VERSION     XP_005267923.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267866.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..463
                     /product="presenilin-1 isoform X2"
                     /calculated_mol_wt=52066
     Region          72..453
                     /region_name="Presenilin"
                     /note="pfam01080"
                     /db_xref="CDD:460052"
     CDS             1..463
                     /gene="PSEN1"
                     /gene_synonym="ACNINV3; AD3; CMD1U; FAD; PS-1; PS1; PSNL1;
                     S182"
                     /coded_by="XM_005267866.3:209..1600"
                     /db_xref="GeneID:5663"
                     /db_xref="HGNC:HGNC:9508"
                     /db_xref="MIM:104311"
ORIGIN      
        1 mtelpaplsy fqnaqmsedn hlsntndnre rqehndrrsl ghpeplsngr pqgnsrqvve
       61 qdeeedeelt lkygakhvim lfvpvtlcmv vvvatiksvs fytrkdgqli ytpftedtet
      121 vgqralhsil naaimisviv vmtillvvly kyrcykviha wliissllll fffsfiylge
      181 vfktynvavd yitvalliwn fgvvgmisih wkgplrlqqa ylimisalma lvfikylpew
      241 tawlilavis vydlvavlcp kgplrmlvet aqernetlfp aliysstmvw lvnmaegdpe
      301 aqrrvsknsk ynaesteres qdtvaenddg gfseeweaqr dshlgphrst pesraavqel
      361 sssilagedp eergvklglg dfifysvlvg kasatasgdw nttiacfvai liglcltlll
      421 laifkkalpa lpisitfglv fyfatdylvq pfmdqlafhq fyi
//
LOCUS       XP_011535276             463 aa            linear   PRI 05-AUG-2025
DEFINITION  presenilin-1 isoform X2 [Homo sapiens].
ACCESSION   XP_011535276
VERSION     XP_011535276.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536974.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..463
                     /product="presenilin-1 isoform X2"
                     /calculated_mol_wt=52066
     Region          72..453
                     /region_name="Presenilin"
                     /note="pfam01080"
                     /db_xref="CDD:460052"
     CDS             1..463
                     /gene="PSEN1"
                     /gene_synonym="ACNINV3; AD3; CMD1U; FAD; PS-1; PS1; PSNL1;
                     S182"
                     /coded_by="XM_011536974.3:1782..3173"
                     /db_xref="GeneID:5663"
                     /db_xref="HGNC:HGNC:9508"
                     /db_xref="MIM:104311"
ORIGIN      
        1 mtelpaplsy fqnaqmsedn hlsntndnre rqehndrrsl ghpeplsngr pqgnsrqvve
       61 qdeeedeelt lkygakhvim lfvpvtlcmv vvvatiksvs fytrkdgqli ytpftedtet
      121 vgqralhsil naaimisviv vmtillvvly kyrcykviha wliissllll fffsfiylge
      181 vfktynvavd yitvalliwn fgvvgmisih wkgplrlqqa ylimisalma lvfikylpew
      241 tawlilavis vydlvavlcp kgplrmlvet aqernetlfp aliysstmvw lvnmaegdpe
      301 aqrrvsknsk ynaesteres qdtvaenddg gfseeweaqr dshlgphrst pesraavqel
      361 sssilagedp eergvklglg dfifysvlvg kasatasgdw nttiacfvai liglcltlll
      421 laifkkalpa lpisitfglv fyfatdylvq pfmdqlafhq fyi
//
LOCUS       XP_011535275             463 aa            linear   PRI 05-AUG-2025
DEFINITION  presenilin-1 isoform X2 [Homo sapiens].
ACCESSION   XP_011535275
VERSION     XP_011535275.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536973.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..463
                     /product="presenilin-1 isoform X2"
                     /calculated_mol_wt=52066
     Region          72..453
                     /region_name="Presenilin"
                     /note="pfam01080"
                     /db_xref="CDD:460052"
     CDS             1..463
                     /gene="PSEN1"
                     /gene_synonym="ACNINV3; AD3; CMD1U; FAD; PS-1; PS1; PSNL1;
                     S182"
                     /coded_by="XM_011536973.3:853..2244"
                     /db_xref="GeneID:5663"
                     /db_xref="HGNC:HGNC:9508"
                     /db_xref="MIM:104311"
ORIGIN      
        1 mtelpaplsy fqnaqmsedn hlsntndnre rqehndrrsl ghpeplsngr pqgnsrqvve
       61 qdeeedeelt lkygakhvim lfvpvtlcmv vvvatiksvs fytrkdgqli ytpftedtet
      121 vgqralhsil naaimisviv vmtillvvly kyrcykviha wliissllll fffsfiylge
      181 vfktynvavd yitvalliwn fgvvgmisih wkgplrlqqa ylimisalma lvfikylpew
      241 tawlilavis vydlvavlcp kgplrmlvet aqernetlfp aliysstmvw lvnmaegdpe
      301 aqrrvsknsk ynaesteres qdtvaenddg gfseeweaqr dshlgphrst pesraavqel
      361 sssilagedp eergvklglg dfifysvlvg kasatasgdw nttiacfvai liglcltlll
      421 laifkkalpa lpisitfglv fyfatdylvq pfmdqlafhq fyi
//
LOCUS       XP_047287558             463 aa            linear   PRI 05-AUG-2025
DEFINITION  presenilin-1 isoform X2 [Homo sapiens].
ACCESSION   XP_047287558
VERSION     XP_047287558.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431602.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..463
                     /product="presenilin-1 isoform X2"
                     /calculated_mol_wt=52066
     Region          72..453
                     /region_name="Presenilin"
                     /note="pfam01080"
                     /db_xref="CDD:460052"
     CDS             1..463
                     /gene="PSEN1"
                     /gene_synonym="ACNINV3; AD3; CMD1U; FAD; PS-1; PS1; PSNL1;
                     S182"
                     /coded_by="XM_047431602.1:168..1559"
                     /db_xref="GeneID:5663"
                     /db_xref="HGNC:HGNC:9508"
                     /db_xref="MIM:104311"
ORIGIN      
        1 mtelpaplsy fqnaqmsedn hlsntndnre rqehndrrsl ghpeplsngr pqgnsrqvve
       61 qdeeedeelt lkygakhvim lfvpvtlcmv vvvatiksvs fytrkdgqli ytpftedtet
      121 vgqralhsil naaimisviv vmtillvvly kyrcykviha wliissllll fffsfiylge
      181 vfktynvavd yitvalliwn fgvvgmisih wkgplrlqqa ylimisalma lvfikylpew
      241 tawlilavis vydlvavlcp kgplrmlvet aqernetlfp aliysstmvw lvnmaegdpe
      301 aqrrvsknsk ynaesteres qdtvaenddg gfseeweaqr dshlgphrst pesraavqel
      361 sssilagedp eergvklglg dfifysvlvg kasatasgdw nttiacfvai liglcltlll
      421 laifkkalpa lpisitfglv fyfatdylvq pfmdqlafhq fyi
//
LOCUS       XP_047287562             333 aa            linear   PRI 05-AUG-2025
DEFINITION  26S proteasome regulatory subunit 10B isoform X1 [Homo sapiens].
ACCESSION   XP_047287562
VERSION     XP_047287562.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431606.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..333
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..333
                     /product="26S proteasome regulatory subunit 10B isoform
                     X1"
                     /calculated_mol_wt=37772
     Region          5..316
                     /region_name="PRK03992"
                     /note="proteasome-activating nucleotidase; Provisional"
                     /db_xref="CDD:179699"
     CDS             1..333
                     /gene="PSMC6"
                     /gene_synonym="p42; RPT5; SUG2"
                     /coded_by="XM_047431606.1:21..1022"
                     /db_xref="GeneID:5706"
                     /db_xref="HGNC:HGNC:9553"
                     /db_xref="MIM:602708"
ORIGIN      
        1 madprdkalq dyrkkllehk eidgrlkelr eqlkeltkqy eksendlkal qsvgqivgev
       61 lkqlteekfi vkatngpryv vgcrrqldks klkpgtrval dmttltimry lprevdplvy
      121 nmshedpgnv syseigglse qirelrevie lpltnpelfq rvgiippkgc llygppgtgk
      181 tllaravasq ldcnflkvvs ssivdkyige sarliremfn yardhqpcii fmdeidaigg
      241 rrfsegtsad reiqrtlmel lnqmdgfdtl hrvkmimatn rpdtldpall rpgrldrkih
      301 idlpneqarl dilkihagpi tkhgeievlv fgy
//
LOCUS       XP_047287563             215 aa            linear   PRI 05-AUG-2025
DEFINITION  26S proteasome regulatory subunit 10B isoform X2 [Homo sapiens].
ACCESSION   XP_047287563
VERSION     XP_047287563.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431607.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..215
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..215
                     /product="26S proteasome regulatory subunit 10B isoform
                     X2"
                     /calculated_mol_wt=24430
     Region          5..>199
                     /region_name="PRK03992"
                     /note="proteasome-activating nucleotidase; Provisional"
                     /db_xref="CDD:179699"
     CDS             1..215
                     /gene="PSMC6"
                     /gene_synonym="p42; RPT5; SUG2"
                     /coded_by="XM_047431607.1:21..668"
                     /db_xref="GeneID:5706"
                     /db_xref="HGNC:HGNC:9553"
                     /db_xref="MIM:602708"
ORIGIN      
        1 madprdkalq dyrkkllehk eidgrlkelr eqlkeltkqy eksendlkal qsvgqivgev
       61 lkqlteekfi vkatngpryv vgcrrqldks klkpgtrval dmttltimry lprevdplvy
      121 nmshedpgnv syseigglse qirelrevie lpltnpelfq rvgiippkgc llygppgtgk
      181 tllaravasq ldcnflkvvv gflrvlqlte rfrer
//
LOCUS       XP_005267936             929 aa            linear   PRI 05-AUG-2025
DEFINITION  X-linked retinitis pigmentosa GTPase regulator-interacting protein
            1 isoform X1 [Homo sapiens].
ACCESSION   XP_005267936
VERSION     XP_005267936.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267879.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..929
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..929
                     /product="X-linked retinitis pigmentosa GTPase
                     regulator-interacting protein 1 isoform X1"
                     /calculated_mol_wt=105874
     Region          260..399
                     /region_name="C2-C2_1"
                     /note="First C2 domain of RPGR-interacting protein 1;
                     pfam11618"
                     /db_xref="CDD:463310"
     Region          443..550
                     /region_name="C2"
                     /note="C2 domain; cd00030"
                     /db_xref="CDD:175973"
     Region          757..922
                     /region_name="RPGR1_C"
                     /note="Retinitis pigmentosa G-protein regulator
                     interacting C-terminal; pfam18111"
                     /db_xref="CDD:465655"
     CDS             1..929
                     /gene="RPGRIP1"
                     /gene_synonym="CORD13; LCA6; RGI1; RGRIP; RPGRIP;
                     RPGRIP1d"
                     /coded_by="XM_005267879.2:67..2856"
                     /db_xref="GeneID:57096"
                     /db_xref="HGNC:HGNC:13436"
                     /db_xref="MIM:605446"
ORIGIN      
        1 mlkldnkdvi shplgypses llsiasmlds sdsssqphws neliaeqlqq qvsqlqdqld
       61 aeledkrkvl lelsrekaqn edlklevtni lqkhkqevel lqnaatisqp pdrqsepath
      121 pavlqentqi epsepknqee kklsqvlnel qvshaettle lektrdmlil qrkinvcyqe
      181 eleammtkad ndnrdhkekl erltrlldlk nnrikqlegi lrshdlptse qlkdvaygtr
      241 plslcletlp ahgdedkvdi sllhqgenlf elhihqaflt saalaqagdt qpttfctysf
      301 ydfethctpl svgpqplydf tsqyvmetds lflhylqeas arldihqama sehstlaagw
      361 icfdrvletv ekvhglatli gaggeefgvl eywmrlrfpi kpslqacnkr kkaqvylstd
      421 vlggrkaqee efrseswepq nelwieitkc cglrsrwlgt qpspyavyrf ftfsdhdtai
      481 ipasnnpyfr dqarfpvlvt sdldhylrre alsihvfdde dlepgsylgr arvpllplak
      541 nesikgdfnl tdpaekpngs iqvqldwkfp yippesflkp eaqtkgkdtk dsskisseee
      601 kasfpsqdqm aspevpieag qyrskrkpph ggerkekehq vvsysrrkhg krigvqgknr
      661 meylslniln gntpeqvnyt ewkfsetnsf igdgfknqhe eeemtlshsa lkqkeplhpv
      721 nadkesseqg sevseaqttd sddvivppms qkypkadsek mcieivslaf ypeaevmsde
      781 nikqvyveyk fydlplsete tpvslrkpra geeihfhfsk vidldpqeqq grrrflfdml
      841 ngqdpdqghl kftvvsdpld eekkeceevg yaylqlwqil esgrdileqe ldivspedla
      901 tpigrlkvsl qaaavlhaiy kemtedlfs
//
LOCUS       XP_011535280             928 aa            linear   PRI 05-AUG-2025
DEFINITION  X-linked retinitis pigmentosa GTPase regulator-interacting protein
            1 isoform X2 [Homo sapiens].
ACCESSION   XP_011535280
VERSION     XP_011535280.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536978.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..928
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..928
                     /product="X-linked retinitis pigmentosa GTPase
                     regulator-interacting protein 1 isoform X2"
                     /calculated_mol_wt=105746
     Region          260..399
                     /region_name="C2-C2_1"
                     /note="First C2 domain of RPGR-interacting protein 1;
                     pfam11618"
                     /db_xref="CDD:463310"
     Region          443..550
                     /region_name="C2"
                     /note="C2 domain; cd00030"
                     /db_xref="CDD:175973"
     Region          756..921
                     /region_name="RPGR1_C"
                     /note="Retinitis pigmentosa G-protein regulator
                     interacting C-terminal; pfam18111"
                     /db_xref="CDD:465655"
     CDS             1..928
                     /gene="RPGRIP1"
                     /gene_synonym="CORD13; LCA6; RGI1; RGRIP; RPGRIP;
                     RPGRIP1d"
                     /coded_by="XM_011536978.1:67..2853"
                     /db_xref="GeneID:57096"
                     /db_xref="HGNC:HGNC:13436"
                     /db_xref="MIM:605446"
ORIGIN      
        1 mlkldnkdvi shplgypses llsiasmlds sdsssqphws neliaeqlqq qvsqlqdqld
       61 aeledkrkvl lelsrekaqn edlklevtni lqkhkqevel lqnaatisqp pdrqsepath
      121 pavlqentqi epsepknqee kklsqvlnel qvshaettle lektrdmlil qrkinvcyqe
      181 eleammtkad ndnrdhkekl erltrlldlk nnrikqlegi lrshdlptse qlkdvaygtr
      241 plslcletlp ahgdedkvdi sllhqgenlf elhihqaflt saalaqagdt qpttfctysf
      301 ydfethctpl svgpqplydf tsqyvmetds lflhylqeas arldihqama sehstlaagw
      361 icfdrvletv ekvhglatli gaggeefgvl eywmrlrfpi kpslqacnkr kkaqvylstd
      421 vlggrkaqee efrseswepq nelwieitkc cglrsrwlgt qpspyavyrf ftfsdhdtai
      481 ipasnnpyfr dqarfpvlvt sdldhylrre alsihvfdde dlepgsylgr arvpllplak
      541 nesikgdfnl tdpaekpngs iqvqldwkfp yippesflkp eaqtkgkdtk dsskisseee
      601 kasfpsqdqm aspevpieag qyrskrkpph ggerkekehq vvsysrrkhg krigvqgknr
      661 meylslniln gntpevnyte wkfsetnsfi gdgfknqhee eemtlshsal kqkeplhpvn
      721 adkesseqgs evseaqttds ddvivppmsq kypkadsekm cieivslafy peaevmsden
      781 ikqvyveykf ydlplsetet pvslrkprag eeihfhfskv idldpqeqqg rrrflfdmln
      841 gqdpdqghlk ftvvsdplde ekkeceevgy aylqlwqile sgrdileqel divspedlat
      901 pigrlkvslq aaavlhaiyk emtedlfs
//
LOCUS       XP_024305431             927 aa            linear   PRI 05-AUG-2025
DEFINITION  X-linked retinitis pigmentosa GTPase regulator-interacting protein
            1 isoform X3 [Homo sapiens].
ACCESSION   XP_024305431
VERSION     XP_024305431.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449663.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..927
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..927
                     /product="X-linked retinitis pigmentosa GTPase
                     regulator-interacting protein 1 isoform X3"
                     /calculated_mol_wt=105675
     Region          260..399
                     /region_name="C2-C2_1"
                     /note="First C2 domain of RPGR-interacting protein 1;
                     pfam11618"
                     /db_xref="CDD:463310"
     Region          443..550
                     /region_name="C2"
                     /note="C2 domain; cd00030"
                     /db_xref="CDD:175973"
     Region          755..920
                     /region_name="RPGR1_C"
                     /note="Retinitis pigmentosa G-protein regulator
                     interacting C-terminal; pfam18111"
                     /db_xref="CDD:465655"
     CDS             1..927
                     /gene="RPGRIP1"
                     /gene_synonym="CORD13; LCA6; RGI1; RGRIP; RPGRIP;
                     RPGRIP1d"
                     /coded_by="XM_024449663.1:67..2850"
                     /db_xref="GeneID:57096"
                     /db_xref="HGNC:HGNC:13436"
                     /db_xref="MIM:605446"
ORIGIN      
        1 mlkldnkdvi shplgypses llsiasmlds sdsssqphws neliaeqlqq qvsqlqdqld
       61 aeledkrkvl lelsrekaqn edlklevtni lqkhkqevel lqnaatisqp pdrqsepath
      121 pavlqentqi epsepknqee kklsqvlnel qvshaettle lektrdmlil qrkinvcyqe
      181 eleammtkad ndnrdhkekl erltrlldlk nnrikqlegi lrshdlptse qlkdvaygtr
      241 plslcletlp ahgdedkvdi sllhqgenlf elhihqaflt saalaqagdt qpttfctysf
      301 ydfethctpl svgpqplydf tsqyvmetds lflhylqeas arldihqama sehstlaagw
      361 icfdrvletv ekvhglatli gaggeefgvl eywmrlrfpi kpslqacnkr kkaqvylstd
      421 vlggrkaqee efrseswepq nelwieitkc cglrsrwlgt qpspyavyrf ftfsdhdtai
      481 ipasnnpyfr dqarfpvlvt sdldhylrre alsihvfdde dlepgsylgr arvpllplak
      541 nesikgdfnl tdpaekpngs iqvqldwkfp yippesflkp eaqtkgkdtk dsskisseee
      601 kasfpsqdqm aspevpieag qyrskrkpph ggerkekehq vvsysrrkhg krigvqgknr
      661 meylslniln gntpevnyte wkfsetnsfi gdgfknqhee eemtlshsal kqkeplhpvn
      721 dkesseqgse vseaqttdsd dvivppmsqk ypkadsekmc ieivslafyp eaevmsdeni
      781 kqvyveykfy dlplsetetp vslrkprage eihfhfskvi dldpqeqqgr rrflfdmlng
      841 qdpdqghlkf tvvsdpldee kkeceevgya ylqlwqiles grdileqeld ivspedlatp
      901 igrlkvslqa aavlhaiyke mtedlfs
//
LOCUS       XP_005267937             918 aa            linear   PRI 05-AUG-2025
DEFINITION  X-linked retinitis pigmentosa GTPase regulator-interacting protein
            1 isoform X4 [Homo sapiens].
ACCESSION   XP_005267937
VERSION     XP_005267937.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267880.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..918
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..918
                     /product="X-linked retinitis pigmentosa GTPase
                     regulator-interacting protein 1 isoform X4"
                     /calculated_mol_wt=104697
     Region          <60..>223
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          249..388
                     /region_name="C2-C2_1"
                     /note="First C2 domain of RPGR-interacting protein 1;
                     pfam11618"
                     /db_xref="CDD:463310"
     Region          432..539
                     /region_name="C2"
                     /note="C2 domain; cd00030"
                     /db_xref="CDD:175973"
     Region          746..911
                     /region_name="RPGR1_C"
                     /note="Retinitis pigmentosa G-protein regulator
                     interacting C-terminal; pfam18111"
                     /db_xref="CDD:465655"
     CDS             1..918
                     /gene="RPGRIP1"
                     /gene_synonym="CORD13; LCA6; RGI1; RGRIP; RPGRIP;
                     RPGRIP1d"
                     /coded_by="XM_005267880.2:67..2823"
                     /db_xref="GeneID:57096"
                     /db_xref="HGNC:HGNC:13436"
                     /db_xref="MIM:605446"
ORIGIN      
        1 mlkldnkdvi shplgypses llsiasmlds sdsssqphws neliaeqlqq qvsqlqdqld
       61 aeledkrkvl lelsrekaqn edlklevtni lqkhkqevel lqnaatisqp pdrqsepath
      121 pavlqentqi epsepknqee kklsqvlnel qvshaettle lektrdmlil qrkinvcyqe
      181 eleammtkad ndnrdhkekl erltrlldlk nnrikqleeq lkdvaygtrp lslcletlpa
      241 hgdedkvdis llhqgenlfe lhihqaflts aalaqagdtq pttfctysfy dfethctpls
      301 vgpqplydft sqyvmetdsl flhylqeasa rldihqamas ehstlaagwi cfdrvletve
      361 kvhglatlig aggeefgvle ywmrlrfpik pslqacnkrk kaqvylstdv lggrkaqeee
      421 frseswepqn elwieitkcc glrsrwlgtq pspyavyrff tfsdhdtaii pasnnpyfrd
      481 qarfpvlvts dldhylrrea lsihvfdded lepgsylgra rvpllplakn esikgdfnlt
      541 dpaekpngsi qvqldwkfpy ippesflkpe aqtkgkdtkd sskisseeek asfpsqdqma
      601 spevpieagq yrskrkpphg gerkekehqv vsysrrkhgk rigvqgknrm eylslnilng
      661 ntpeqvnyte wkfsetnsfi gdgfknqhee eemtlshsal kqkeplhpvn adkesseqgs
      721 evseaqttds ddvivppmsq kypkadsekm cieivslafy peaevmsden ikqvyveykf
      781 ydlplsetet pvslrkprag eeihfhfskv idldpqeqqg rrrflfdmln gqdpdqghlk
      841 ftvvsdplde ekkeceevgy aylqlwqile sgrdileqel divspedlat pigrlkvslq
      901 aaavlhaiyk emtedlfs
//
LOCUS       XP_011535281             857 aa            linear   PRI 05-AUG-2025
DEFINITION  X-linked retinitis pigmentosa GTPase regulator-interacting protein
            1 isoform X5 [Homo sapiens].
ACCESSION   XP_011535281
VERSION     XP_011535281.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536979.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..857
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..857
                     /product="X-linked retinitis pigmentosa GTPase
                     regulator-interacting protein 1 isoform X5"
                     /calculated_mol_wt=97692
     Region          <257..327
                     /region_name="C2-C2_1"
                     /note="First C2 domain of RPGR-interacting protein 1;
                     pfam11618"
                     /db_xref="CDD:463310"
     Region          371..478
                     /region_name="C2"
                     /note="C2 domain; cd00030"
                     /db_xref="CDD:175973"
     Region          685..850
                     /region_name="RPGR1_C"
                     /note="Retinitis pigmentosa G-protein regulator
                     interacting C-terminal; pfam18111"
                     /db_xref="CDD:465655"
     CDS             1..857
                     /gene="RPGRIP1"
                     /gene_synonym="CORD13; LCA6; RGI1; RGRIP; RPGRIP;
                     RPGRIP1d"
                     /coded_by="XM_011536979.1:67..2640"
                     /db_xref="GeneID:57096"
                     /db_xref="HGNC:HGNC:13436"
                     /db_xref="MIM:605446"
ORIGIN      
        1 mlkldnkdvi shplgypses llsiasmlds sdsssqphws neliaeqlqq qvsqlqdqld
       61 aeledkrkvl lelsrekaqn edlklevtni lqkhkqevel lqnaatisqp pdrqsepath
      121 pavlqentqi epsepknqee kklsqvlnel qvshaettle lektrdmlil qrkinvcyqe
      181 eleammtkad ndnrdhkekl erltrlldlk nnrikqlegi lrshdlptse qlkdvaygtr
      241 plslcletlp ahgdedkvdi sllhqeasar ldihqamase hstlaagwic fdrvletvek
      301 vhglatliga ggeefgvley wmrlrfpikp slqacnkrkk aqvylstdvl ggrkaqeeef
      361 rseswepqne lwieitkccg lrsrwlgtqp spyavyrfft fsdhdtaiip asnnpyfrdq
      421 arfpvlvtsd ldhylrreal sihvfddedl epgsylgrar vpllplakne sikgdfnltd
      481 paekpngsiq vqldwkfpyi ppesflkpea qtkgkdtkds skisseeeka sfpsqdqmas
      541 pevpieagqy rskrkpphgg erkekehqvv sysrrkhgkr igvqgknrme ylslnilngn
      601 tpeqvnytew kfsetnsfig dgfknqheee emtlshsalk qkeplhpvna dkesseqgse
      661 vseaqttdsd dvivppmsqk ypkadsekmc ieivslafyp eaevmsdeni kqvyveykfy
      721 dlplsetetp vslrkprage eihfhfskvi dldpqeqqgr rrflfdmlng qdpdqghlkf
      781 tvvsdpldee kkeceevgya ylqlwqiles grdileqeld ivspedlatp igrlkvslqa
      841 aavlhaiyke mtedlfs
//
LOCUS       XP_011535283             764 aa            linear   PRI 05-AUG-2025
DEFINITION  X-linked retinitis pigmentosa GTPase regulator-interacting protein
            1 isoform X6 [Homo sapiens].
ACCESSION   XP_011535283
VERSION     XP_011535283.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536981.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..764
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..764
                     /product="X-linked retinitis pigmentosa GTPase
                     regulator-interacting protein 1 isoform X6"
                     /calculated_mol_wt=86835
     Region          260..381
                     /region_name="C2-C2_1"
                     /note="First C2 domain of RPGR-interacting protein 1;
                     pfam11618"
                     /db_xref="CDD:463310"
     Region          592..757
                     /region_name="RPGR1_C"
                     /note="Retinitis pigmentosa G-protein regulator
                     interacting C-terminal; pfam18111"
                     /db_xref="CDD:465655"
     CDS             1..764
                     /gene="RPGRIP1"
                     /gene_synonym="CORD13; LCA6; RGI1; RGRIP; RPGRIP;
                     RPGRIP1d"
                     /coded_by="XM_011536981.1:67..2361"
                     /db_xref="GeneID:57096"
                     /db_xref="HGNC:HGNC:13436"
                     /db_xref="MIM:605446"
ORIGIN      
        1 mlkldnkdvi shplgypses llsiasmlds sdsssqphws neliaeqlqq qvsqlqdqld
       61 aeledkrkvl lelsrekaqn edlklevtni lqkhkqevel lqnaatisqp pdrqsepath
      121 pavlqentqi epsepknqee kklsqvlnel qvshaettle lektrdmlil qrkinvcyqe
      181 eleammtkad ndnrdhkekl erltrlldlk nnrikqlegi lrshdlptse qlkdvaygtr
      241 plslcletlp ahgdedkvdi sllhqgenlf elhihqaflt saalaqagdt qpttfctysf
      301 ydfethctpl svgpqplydf tsqyvmetds lflhylqeas arldihqama sehstlaagw
      361 icfdrvletv ekvhglatli gdfnltdpae kpngsiqvql dwkfpyippe sflkpeaqtk
      421 gkdtkdsski sseeekasfp sqdqmaspev pieagqyrsk rkpphggerk ekehqvvsys
      481 rrkhgkrigv qgknrmeyls lnilngntpe qvnytewkfs etnsfigdgf knqheeeemt
      541 lshsalkqke plhpvnadke sseqgsevse aqttdsddvi vppmsqkypk adsekmciei
      601 vslafypeae vmsdenikqv yveykfydlp lsetetpvsl rkprageeih fhfskvidld
      661 pqeqqgrrrf lfdmlngqdp dqghlkftvv sdpldeekke ceevgyaylq lwqilesgrd
      721 ileqeldivs pedlatpigr lkvslqaaav lhaiykemte dlfs
//
LOCUS       XP_016876962             763 aa            linear   PRI 05-AUG-2025
DEFINITION  X-linked retinitis pigmentosa GTPase regulator-interacting protein
            1 isoform X7 [Homo sapiens].
ACCESSION   XP_016876962
VERSION     XP_016876962.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021473.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..763
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..763
                     /product="X-linked retinitis pigmentosa GTPase
                     regulator-interacting protein 1 isoform X7"
                     /calculated_mol_wt=86706
     Region          260..381
                     /region_name="C2-C2_1"
                     /note="First C2 domain of RPGR-interacting protein 1;
                     pfam11618"
                     /db_xref="CDD:463310"
     Region          591..756
                     /region_name="RPGR1_C"
                     /note="Retinitis pigmentosa G-protein regulator
                     interacting C-terminal; pfam18111"
                     /db_xref="CDD:465655"
     CDS             1..763
                     /gene="RPGRIP1"
                     /gene_synonym="CORD13; LCA6; RGI1; RGRIP; RPGRIP;
                     RPGRIP1d"
                     /coded_by="XM_017021473.2:67..2358"
                     /db_xref="GeneID:57096"
                     /db_xref="HGNC:HGNC:13436"
                     /db_xref="MIM:605446"
ORIGIN      
        1 mlkldnkdvi shplgypses llsiasmlds sdsssqphws neliaeqlqq qvsqlqdqld
       61 aeledkrkvl lelsrekaqn edlklevtni lqkhkqevel lqnaatisqp pdrqsepath
      121 pavlqentqi epsepknqee kklsqvlnel qvshaettle lektrdmlil qrkinvcyqe
      181 eleammtkad ndnrdhkekl erltrlldlk nnrikqlegi lrshdlptse qlkdvaygtr
      241 plslcletlp ahgdedkvdi sllhqgenlf elhihqaflt saalaqagdt qpttfctysf
      301 ydfethctpl svgpqplydf tsqyvmetds lflhylqeas arldihqama sehstlaagw
      361 icfdrvletv ekvhglatli gdfnltdpae kpngsiqvql dwkfpyippe sflkpeaqtk
      421 gkdtkdsski sseeekasfp sqdqmaspev pieagqyrsk rkpphggerk ekehqvvsys
      481 rrkhgkrigv qgknrmeyls lnilngntpe vnytewkfse tnsfigdgfk nqheeeemtl
      541 shsalkqkep lhpvnadkes seqgsevsea qttdsddviv ppmsqkypka dsekmcieiv
      601 slafypeaev msdenikqvy veykfydlpl setetpvslr kprageeihf hfskvidldp
      661 qeqqgrrrfl fdmlngqdpd qghlkftvvs dpldeekkec eevgyaylql wqilesgrdi
      721 leqeldivsp edlatpigrl kvslqaaavl haiykemted lfs
//
LOCUS       XP_024305432             762 aa            linear   PRI 05-AUG-2025
DEFINITION  X-linked retinitis pigmentosa GTPase regulator-interacting protein
            1 isoform X8 [Homo sapiens].
ACCESSION   XP_024305432
VERSION     XP_024305432.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449664.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..762
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..762
                     /product="X-linked retinitis pigmentosa GTPase
                     regulator-interacting protein 1 isoform X8"
                     /calculated_mol_wt=86635
     Region          260..381
                     /region_name="C2-C2_1"
                     /note="First C2 domain of RPGR-interacting protein 1;
                     pfam11618"
                     /db_xref="CDD:463310"
     Region          590..755
                     /region_name="RPGR1_C"
                     /note="Retinitis pigmentosa G-protein regulator
                     interacting C-terminal; pfam18111"
                     /db_xref="CDD:465655"
     CDS             1..762
                     /gene="RPGRIP1"
                     /gene_synonym="CORD13; LCA6; RGI1; RGRIP; RPGRIP;
                     RPGRIP1d"
                     /coded_by="XM_024449664.1:67..2355"
                     /db_xref="GeneID:57096"
                     /db_xref="HGNC:HGNC:13436"
                     /db_xref="MIM:605446"
ORIGIN      
        1 mlkldnkdvi shplgypses llsiasmlds sdsssqphws neliaeqlqq qvsqlqdqld
       61 aeledkrkvl lelsrekaqn edlklevtni lqkhkqevel lqnaatisqp pdrqsepath
      121 pavlqentqi epsepknqee kklsqvlnel qvshaettle lektrdmlil qrkinvcyqe
      181 eleammtkad ndnrdhkekl erltrlldlk nnrikqlegi lrshdlptse qlkdvaygtr
      241 plslcletlp ahgdedkvdi sllhqgenlf elhihqaflt saalaqagdt qpttfctysf
      301 ydfethctpl svgpqplydf tsqyvmetds lflhylqeas arldihqama sehstlaagw
      361 icfdrvletv ekvhglatli gdfnltdpae kpngsiqvql dwkfpyippe sflkpeaqtk
      421 gkdtkdsski sseeekasfp sqdqmaspev pieagqyrsk rkpphggerk ekehqvvsys
      481 rrkhgkrigv qgknrmeyls lnilngntpe vnytewkfse tnsfigdgfk nqheeeemtl
      541 shsalkqkep lhpvndkess eqgsevseaq ttdsddvivp pmsqkypkad sekmcieivs
      601 lafypeaevm sdenikqvyv eykfydlpls etetpvslrk prageeihfh fskvidldpq
      661 eqqgrrrflf dmlngqdpdq ghlkftvvsd pldeekkece evgyaylqlw qilesgrdil
      721 eqeldivspe dlatpigrlk vslqaaavlh aiykemtedl fs
//
LOCUS       XP_005267938             745 aa            linear   PRI 05-AUG-2025
DEFINITION  X-linked retinitis pigmentosa GTPase regulator-interacting protein
            1 isoform X9 [Homo sapiens].
ACCESSION   XP_005267938
VERSION     XP_005267938.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267881.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..745
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..745
                     /product="X-linked retinitis pigmentosa GTPase
                     regulator-interacting protein 1 isoform X9"
                     /calculated_mol_wt=84882
     Region          76..215
                     /region_name="C2-C2_1"
                     /note="First C2 domain of RPGR-interacting protein 1;
                     pfam11618"
                     /db_xref="CDD:463310"
     Region          259..366
                     /region_name="C2"
                     /note="C2 domain; cd00030"
                     /db_xref="CDD:175973"
     Region          573..738
                     /region_name="RPGR1_C"
                     /note="Retinitis pigmentosa G-protein regulator
                     interacting C-terminal; pfam18111"
                     /db_xref="CDD:465655"
     CDS             1..745
                     /gene="RPGRIP1"
                     /gene_synonym="CORD13; LCA6; RGI1; RGRIP; RPGRIP;
                     RPGRIP1d"
                     /coded_by="XM_005267881.3:114..2351"
                     /db_xref="GeneID:57096"
                     /db_xref="HGNC:HGNC:13436"
                     /db_xref="MIM:605446"
ORIGIN      
        1 mmtkadndnr dhkeklerlt rlldlknnri kqlegilrsh dlptseqlkd vaygtrplsl
       61 cletlpahgd edkvdisllh qgenlfelhi hqafltsaal aqagdtqptt fctysfydfe
      121 thctplsvgp qplydftsqy vmetdslflh ylqeasarld ihqamasehs tlaagwicfd
      181 rvletvekvh glatligagg eefgvleywm rlrfpikpsl qacnkrkkaq vylstdvlgg
      241 rkaqeeefrs eswepqnelw ieitkccglr srwlgtqpsp yavyrfftfs dhdtaiipas
      301 nnpyfrdqar fpvlvtsdld hylrrealsi hvfddedlep gsylgrarvp llplaknesi
      361 kgdfnltdpa ekpngsiqvq ldwkfpyipp esflkpeaqt kgkdtkdssk isseeekasf
      421 psqdqmaspe vpieagqyrs krkpphgger kekehqvvsy srrkhgkrig vqgknrmeyl
      481 slnilngntp eqvnytewkf setnsfigdg fknqheeeem tlshsalkqk eplhpvnadk
      541 esseqgsevs eaqttdsddv ivppmsqkyp kadsekmcie ivslafypea evmsdenikq
      601 vyveykfydl plsetetpvs lrkprageei hfhfskvidl dpqeqqgrrr flfdmlngqd
      661 pdqghlkftv vsdpldeekk eceevgyayl qlwqilesgr dileqeldiv spedlatpig
      721 rlkvslqaaa vlhaiykemt edlfs
//
LOCUS       XP_011535284             649 aa            linear   PRI 05-AUG-2025
DEFINITION  X-linked retinitis pigmentosa GTPase regulator-interacting protein
            1 isoform X10 [Homo sapiens].
ACCESSION   XP_011535284
VERSION     XP_011535284.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536982.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..649
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..649
                     /product="X-linked retinitis pigmentosa GTPase
                     regulator-interacting protein 1 isoform X10"
                     /calculated_mol_wt=73979
     Region          477..642
                     /region_name="RPGR1_C"
                     /note="Retinitis pigmentosa G-protein regulator
                     interacting C-terminal; pfam18111"
                     /db_xref="CDD:465655"
     CDS             1..649
                     /gene="RPGRIP1"
                     /gene_synonym="CORD13; LCA6; RGI1; RGRIP; RPGRIP;
                     RPGRIP1d"
                     /coded_by="XM_011536982.1:67..2016"
                     /db_xref="GeneID:57096"
                     /db_xref="HGNC:HGNC:13436"
                     /db_xref="MIM:605446"
ORIGIN      
        1 mlkldnkdvi shplgypses llsiasmlds sdsssqphws neliaeqlqq qvsqlqdqld
       61 aeledkrkvl lelsrekaqn edlklevtni lqkhkqevel lqnaatisqp pdrqsepath
      121 pavlqentqi epsepknqee kklsqvlnel qvshaettle lektrdmlil qrkinvcyqe
      181 eleammtkad ndnrdhkekl erltrlldlk nnrikqlegi lrshdlptse qlkdvaygtr
      241 plslcletlp ahgdedkvdi sllhqgdfnl tdpaekpngs iqvqldwkfp yippesflkp
      301 eaqtkgkdtk dsskisseee kasfpsqdqm aspevpieag qyrskrkpph ggerkekehq
      361 vvsysrrkhg krigvqgknr meylslniln gntpeqvnyt ewkfsetnsf igdgfknqhe
      421 eeemtlshsa lkqkeplhpv nadkesseqg sevseaqttd sddvivppms qkypkadsek
      481 mcieivslaf ypeaevmsde nikqvyveyk fydlplsete tpvslrkpra geeihfhfsk
      541 vidldpqeqq grrrflfdml ngqdpdqghl kftvvsdpld eekkeceevg yaylqlwqil
      601 esgrdileqe ldivspedla tpigrlkvsl qaaavlhaiy kemtedlfs
//
LOCUS       XP_024305434             647 aa            linear   PRI 05-AUG-2025
DEFINITION  X-linked retinitis pigmentosa GTPase regulator-interacting protein
            1 isoform X11 [Homo sapiens].
ACCESSION   XP_024305434
VERSION     XP_024305434.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449666.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..647
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..647
                     /product="X-linked retinitis pigmentosa GTPase
                     regulator-interacting protein 1 isoform X11"
                     /calculated_mol_wt=73780
     Region          475..640
                     /region_name="RPGR1_C"
                     /note="Retinitis pigmentosa G-protein regulator
                     interacting C-terminal; pfam18111"
                     /db_xref="CDD:465655"
     CDS             1..647
                     /gene="RPGRIP1"
                     /gene_synonym="CORD13; LCA6; RGI1; RGRIP; RPGRIP;
                     RPGRIP1d"
                     /coded_by="XM_024449666.1:67..2010"
                     /db_xref="GeneID:57096"
                     /db_xref="HGNC:HGNC:13436"
                     /db_xref="MIM:605446"
ORIGIN      
        1 mlkldnkdvi shplgypses llsiasmlds sdsssqphws neliaeqlqq qvsqlqdqld
       61 aeledkrkvl lelsrekaqn edlklevtni lqkhkqevel lqnaatisqp pdrqsepath
      121 pavlqentqi epsepknqee kklsqvlnel qvshaettle lektrdmlil qrkinvcyqe
      181 eleammtkad ndnrdhkekl erltrlldlk nnrikqlegi lrshdlptse qlkdvaygtr
      241 plslcletlp ahgdedkvdi sllhqgdfnl tdpaekpngs iqvqldwkfp yippesflkp
      301 eaqtkgkdtk dsskisseee kasfpsqdqm aspevpieag qyrskrkpph ggerkekehq
      361 vvsysrrkhg krigvqgknr meylslniln gntpevnyte wkfsetnsfi gdgfknqhee
      421 eemtlshsal kqkeplhpvn dkesseqgse vseaqttdsd dvivppmsqk ypkadsekmc
      481 ieivslafyp eaevmsdeni kqvyveykfy dlplsetetp vslrkprage eihfhfskvi
      541 dldpqeqqgr rrflfdmlng qdpdqghlkf tvvsdpldee kkeceevgya ylqlwqiles
      601 grdileqeld ivspedlatp igrlkvslqa aavlhaiyke mtedlfs
//
LOCUS       XP_047287565             613 aa            linear   PRI 05-AUG-2025
DEFINITION  X-linked retinitis pigmentosa GTPase regulator-interacting protein
            1 isoform X12 [Homo sapiens].
ACCESSION   XP_047287565
VERSION     XP_047287565.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431609.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..613
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..613
                     /product="X-linked retinitis pigmentosa GTPase
                     regulator-interacting protein 1 isoform X12"
                     /calculated_mol_wt=69992
     Region          441..606
                     /region_name="RPGR1_C"
                     /note="Retinitis pigmentosa G-protein regulator
                     interacting C-terminal; pfam18111"
                     /db_xref="CDD:465655"
     CDS             1..613
                     /gene="RPGRIP1"
                     /gene_synonym="CORD13; LCA6; RGI1; RGRIP; RPGRIP;
                     RPGRIP1d"
                     /coded_by="XM_047431609.1:67..1908"
                     /db_xref="GeneID:57096"
                     /db_xref="HGNC:HGNC:13436"
                     /db_xref="MIM:605446"
ORIGIN      
        1 mlkldnkdvi shplgypses llsiasmlds sdsssqphws neliaeqlqq qvsqlqdqld
       61 aeledkrkvl lelsrekaqn edlklevtni lqkhkqevel lqnaatisqp pdrqsepath
      121 pavlqentqi epsepknqee kklsqvlnel qvshaettle lektrdmlil qrkinvcyqe
      181 eleammtkad ndnrdhkekl erltrlldlk nnrikqlegi lrshdlptsg dfnltdpaek
      241 pngsiqvqld wkfpyippes flkpeaqtkg kdtkdsskis seeekasfps qdqmaspevp
      301 ieagqyrskr kpphggerke kehqvvsysr rkhgkrigvq gknrmeylsl nilngntpeq
      361 vnytewkfse tnsfigdgfk nqheeeemtl shsalkqkep lhpvnadkes seqgsevsea
      421 qttdsddviv ppmsqkypka dsekmcieiv slafypeaev msdenikqvy veykfydlpl
      481 setetpvslr kprageeihf hfskvidldp qeqqgrrrfl fdmlngqdpd qghlkftvvs
      541 dpldeekkec eevgyaylql wqilesgrdi leqeldivsp edlatpigrl kvslqaaavl
      601 haiykemted lfs
//
LOCUS       XP_047287566             464 aa            linear   PRI 05-AUG-2025
DEFINITION  aarF domain-containing protein kinase 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047287566
VERSION     XP_047287566.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431610.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..464
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..464
                     /product="aarF domain-containing protein kinase 1 isoform
                     X1"
                     /calculated_mol_wt=53110
     Region          58..310
                     /region_name="ADCK1-like"
                     /note="aarF domain containing kinase 1 and similar
                     proteins; cd13969"
                     /db_xref="CDD:270871"
     Site            order(108..112,114,124,126,185,204..207,249,253..254,256,
                     271..272)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:270871"
     CDS             1..464
                     /gene="ADCK1"
                     /gene_synonym="MCP2"
                     /coded_by="XM_047431610.1:71..1465"
                     /db_xref="GeneID:57143"
                     /db_xref="HGNC:HGNC:19038"
                     /db_xref="MIM:620399"
ORIGIN      
        1 miclpwspkl lglqvhlrsa rrlcelccan rgtfikvgqh lgaldyllpe eytstlkvlh
       61 sqapqssmqe irqviredlg keihdlfqsf ddtplgtasl aqvhkavlhd grtvavkvqh
      121 pkvraqsskd illmevlvla vkqlfpefef mwlvdeakkn lpleldflne grnaekvsqm
      181 lrhfdflkvp rihwdlster vllmefvdgg qvndrdymer nkidvneisr hlgkmysemi
      241 fvngfvhcdp hpgnvlvrkh pgtgkaeivl ldhglyqmlt eefrlnychl wqsliwtdmk
      301 rvkeysqrlg agdlyplfac mltarswdsv nrgisqapvt atedleirnn aanylpqish
      361 llnhvprqml lilktndllr gieaalgtra sassflnmsr cciralaehk kkntcsffrr
      421 tqisfseafn lwqinlheli lrvkglklad rvlalicwlf papl
//
LOCUS       XP_047287567             397 aa            linear   PRI 05-AUG-2025
DEFINITION  aarF domain-containing protein kinase 1 isoform X2 [Homo sapiens].
ACCESSION   XP_047287567
VERSION     XP_047287567.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431611.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..397
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..397
                     /product="aarF domain-containing protein kinase 1 isoform
                     X2"
                     /calculated_mol_wt=45635
     Region          1..243
                     /region_name="ADCK1-like"
                     /note="aarF domain containing kinase 1 and similar
                     proteins; cd13969"
                     /db_xref="CDD:270871"
     Site            order(41..45,47,57,59,118,137..140,182,186..187,189,
                     204..205)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:270871"
     CDS             1..397
                     /gene="ADCK1"
                     /gene_synonym="MCP2"
                     /coded_by="XM_047431611.1:255..1448"
                     /db_xref="GeneID:57143"
                     /db_xref="HGNC:HGNC:19038"
                     /db_xref="MIM:620399"
ORIGIN      
        1 mqeirqvire dlgkeihdlf qsfddtplgt aslaqvhkav lhdgrtvavk vqhpkvraqs
       61 skdillmevl vlavkqlfpe fefmwlvdea kknlpleldf lnegrnaekv sqmlrhfdfl
      121 kvprihwdls tervllmefv dggqvndrdy mernkidvne isrhlgkmys emifvngfvh
      181 cdphpgnvlv rkhpgtgkae ivlldhglyq mlteefrlny chlwqsliwt dmkrvkeysq
      241 rlgagdlypl facmltarsw dsvnrgisqa pvtatedlei rnnaanylpq ishllnhvpr
      301 qmllilktnd llrgieaalg trasassfln msrccirala ehkkkntcsf frrtqisfse
      361 afnlwqinlh elilrvkglk ladrvlalic wlfpapl
//
LOCUS       XP_016876966             397 aa            linear   PRI 05-AUG-2025
DEFINITION  aarF domain-containing protein kinase 1 isoform X2 [Homo sapiens].
ACCESSION   XP_016876966
VERSION     XP_016876966.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021477.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..397
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..397
                     /product="aarF domain-containing protein kinase 1 isoform
                     X2"
                     /calculated_mol_wt=45635
     Region          1..243
                     /region_name="ADCK1-like"
                     /note="aarF domain containing kinase 1 and similar
                     proteins; cd13969"
                     /db_xref="CDD:270871"
     Site            order(41..45,47,57,59,118,137..140,182,186..187,189,
                     204..205)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:270871"
     CDS             1..397
                     /gene="ADCK1"
                     /gene_synonym="MCP2"
                     /coded_by="XM_017021477.2:176..1369"
                     /db_xref="GeneID:57143"
                     /db_xref="HGNC:HGNC:19038"
                     /db_xref="MIM:620399"
ORIGIN      
        1 mqeirqvire dlgkeihdlf qsfddtplgt aslaqvhkav lhdgrtvavk vqhpkvraqs
       61 skdillmevl vlavkqlfpe fefmwlvdea kknlpleldf lnegrnaekv sqmlrhfdfl
      121 kvprihwdls tervllmefv dggqvndrdy mernkidvne isrhlgkmys emifvngfvh
      181 cdphpgnvlv rkhpgtgkae ivlldhglyq mlteefrlny chlwqsliwt dmkrvkeysq
      241 rlgagdlypl facmltarsw dsvnrgisqa pvtatedlei rnnaanylpq ishllnhvpr
      301 qmllilktnd llrgieaalg trasassfln msrccirala ehkkkntcsf frrtqisfse
      361 afnlwqinlh elilrvkglk ladrvlalic wlfpapl
//
LOCUS       XP_011535287             296 aa            linear   PRI 05-AUG-2025
DEFINITION  aarF domain-containing protein kinase 1 isoform X3 [Homo sapiens].
ACCESSION   XP_011535287
VERSION     XP_011535287.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536985.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..296
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..296
                     /product="aarF domain-containing protein kinase 1 isoform
                     X3"
                     /calculated_mol_wt=33812
     Region          <16..142
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..296
                     /gene="ADCK1"
                     /gene_synonym="MCP2"
                     /coded_by="XM_011536985.2:147..1037"
                     /db_xref="GeneID:57143"
                     /db_xref="HGNC:HGNC:19038"
                     /db_xref="MIM:620399"
ORIGIN      
        1 mgqkvvrpdv gdsptrsdve vprihwdlst ervllmefvd ggqvndrdym ernkidvnei
       61 srhlgkmyse mifvngfvhc dphpgnvlvr khpgtgkaei vlldhglyqm lteefrlnyc
      121 hlwqsliwtd mkrvkeysqr lgagdlyplf acmltarswd svnrgisqap vtatedleir
      181 nnaanylpqi shllnhvprq mllilktndl lrgieaalgt rasassflnm srcciralae
      241 hkkkntcsff rrtqisfsea fnlwqinlhe lilrvkglkl adrvlalicw lfpapl
//
LOCUS       XP_016876967             407 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase pellino homolog 2 isoform X1 [Homo
            sapiens].
ACCESSION   XP_016876967
VERSION     XP_016876967.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021478.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..407
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..407
                     /product="E3 ubiquitin-protein ligase pellino homolog 2
                     isoform X1"
                     /calculated_mol_wt=44916
     Region          10..407
                     /region_name="Pellino"
                     /note="pfam04710"
                     /db_xref="CDD:461403"
     CDS             1..407
                     /gene="PELI2"
                     /coded_by="XM_017021478.2:2714..3937"
                     /db_xref="GeneID:57161"
                     /db_xref="HGNC:HGNC:8828"
                     /db_xref="MIM:614798"
ORIGIN      
        1 mlawpfhsnv vlgyngalpn gdrgrrksrf alykrpkang vkpstvhvis tpqaskaisc
       61 kgqhsisytl srnqtvvvey thdkdtdmfq vgrstespid fvvtdtisgs qntdeaqitq
      121 stisrfacri vcdrnepyta rifaagfdss kniflgekaa kwknpdghmd glttngvlvm
      181 hprggftees qpgvwreisv cgdvytlret rsaqqrgklv esetnvlqdg slidlcgatl
      241 lwrtadglfh tptqkhieal rqeinaarpq cpvglntlaf psinrkevve ekqpwaylsc
      301 ghvhgyhnwg hrsdteaner ecpmcrtvgp yvplwlgcea gfyvdagppt haftpcghvc
      361 seksakywsq iplphgthaf haacpfcatq lvgeqncikl ifqgpid
//
LOCUS       XP_011535292             320 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase pellino homolog 2 isoform X2 [Homo
            sapiens].
ACCESSION   XP_011535292
VERSION     XP_011535292.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536990.3
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 25% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..320
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..320
                     /product="E3 ubiquitin-protein ligase pellino homolog 2
                     isoform X2"
                     /calculated_mol_wt=35278
     Region          <1..320
                     /region_name="Pellino"
                     /note="pfam04710"
                     /db_xref="CDD:461403"
     CDS             1..320
                     /gene="PELI2"
                     /coded_by="XM_011536990.3:605..1567"
                     /db_xref="GeneID:57161"
                     /db_xref="HGNC:HGNC:8828"
                     /db_xref="MIM:614798"
ORIGIN      
        1 mfqvgrstes pidfvvtdti sgsqntdeaq itqstisrfa crivcdrnep ytarifaagf
       61 dsskniflge kaakwknpdg hmdglttngv lvmhprggft eesqpgvwre isvcgdvytl
      121 retrsaqqrg klvesetnvl qdgslidlcg atllwrtadg lfhtptqkhi ealrqeinaa
      181 rpqcpvglnt lafpsinrke vveekqpway lscghvhgyh nwghrsdtea nerecpmcrt
      241 vgpyvplwlg ceagfyvdag ppthaftpcg hvcseksaky wsqiplphgt hafhaacpfc
      301 atqlvgeqnc iklifqgpid
//
LOCUS       XP_016876968             320 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase pellino homolog 2 isoform X2 [Homo
            sapiens].
ACCESSION   XP_016876968
VERSION     XP_016876968.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021479.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..320
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..320
                     /product="E3 ubiquitin-protein ligase pellino homolog 2
                     isoform X2"
                     /calculated_mol_wt=35278
     Region          <1..320
                     /region_name="Pellino"
                     /note="pfam04710"
                     /db_xref="CDD:461403"
     CDS             1..320
                     /gene="PELI2"
                     /coded_by="XM_017021479.2:843..1805"
                     /db_xref="GeneID:57161"
                     /db_xref="HGNC:HGNC:8828"
                     /db_xref="MIM:614798"
ORIGIN      
        1 mfqvgrstes pidfvvtdti sgsqntdeaq itqstisrfa crivcdrnep ytarifaagf
       61 dsskniflge kaakwknpdg hmdglttngv lvmhprggft eesqpgvwre isvcgdvytl
      121 retrsaqqrg klvesetnvl qdgslidlcg atllwrtadg lfhtptqkhi ealrqeinaa
      181 rpqcpvglnt lafpsinrke vveekqpway lscghvhgyh nwghrsdtea nerecpmcrt
      241 vgpyvplwlg ceagfyvdag ppthaftpcg hvcseksaky wsqiplphgt hafhaacpfc
      301 atqlvgeqnc iklifqgpid
//
LOCUS       XP_011535294             320 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase pellino homolog 2 isoform X2 [Homo
            sapiens].
ACCESSION   XP_011535294
VERSION     XP_011535294.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536992.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..320
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..320
                     /product="E3 ubiquitin-protein ligase pellino homolog 2
                     isoform X2"
                     /calculated_mol_wt=35278
     Region          <1..320
                     /region_name="Pellino"
                     /note="pfam04710"
                     /db_xref="CDD:461403"
     CDS             1..320
                     /gene="PELI2"
                     /coded_by="XM_011536992.4:351..1313"
                     /db_xref="GeneID:57161"
                     /db_xref="HGNC:HGNC:8828"
                     /db_xref="MIM:614798"
ORIGIN      
        1 mfqvgrstes pidfvvtdti sgsqntdeaq itqstisrfa crivcdrnep ytarifaagf
       61 dsskniflge kaakwknpdg hmdglttngv lvmhprggft eesqpgvwre isvcgdvytl
      121 retrsaqqrg klvesetnvl qdgslidlcg atllwrtadg lfhtptqkhi ealrqeinaa
      181 rpqcpvglnt lafpsinrke vveekqpway lscghvhgyh nwghrsdtea nerecpmcrt
      241 vgpyvplwlg ceagfyvdag ppthaftpcg hvcseksaky wsqiplphgt hafhaacpfc
      301 atqlvgeqnc iklifqgpid
//
LOCUS       XP_006720274             320 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase pellino homolog 2 isoform X2 [Homo
            sapiens].
ACCESSION   XP_006720274
VERSION     XP_006720274.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720211.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..320
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..320
                     /product="E3 ubiquitin-protein ligase pellino homolog 2
                     isoform X2"
                     /calculated_mol_wt=35278
     Region          <1..320
                     /region_name="Pellino"
                     /note="pfam04710"
                     /db_xref="CDD:461403"
     CDS             1..320
                     /gene="PELI2"
                     /coded_by="XM_006720211.4:4136..5098"
                     /db_xref="GeneID:57161"
                     /db_xref="HGNC:HGNC:8828"
                     /db_xref="MIM:614798"
ORIGIN      
        1 mfqvgrstes pidfvvtdti sgsqntdeaq itqstisrfa crivcdrnep ytarifaagf
       61 dsskniflge kaakwknpdg hmdglttngv lvmhprggft eesqpgvwre isvcgdvytl
      121 retrsaqqrg klvesetnvl qdgslidlcg atllwrtadg lfhtptqkhi ealrqeinaa
      181 rpqcpvglnt lafpsinrke vveekqpway lscghvhgyh nwghrsdtea nerecpmcrt
      241 vgpyvplwlg ceagfyvdag ppthaftpcg hvcseksaky wsqiplphgt hafhaacpfc
      301 atqlvgeqnc iklifqgpid
//
LOCUS       XP_047287568             320 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase pellino homolog 2 isoform X2 [Homo
            sapiens].
ACCESSION   XP_047287568
VERSION     XP_047287568.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431612.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..320
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..320
                     /product="E3 ubiquitin-protein ligase pellino homolog 2
                     isoform X2"
                     /calculated_mol_wt=35278
     Region          <1..320
                     /region_name="Pellino"
                     /note="pfam04710"
                     /db_xref="CDD:461403"
     CDS             1..320
                     /gene="PELI2"
                     /coded_by="XM_047431612.1:44100..45062"
                     /db_xref="GeneID:57161"
                     /db_xref="HGNC:HGNC:8828"
                     /db_xref="MIM:614798"
ORIGIN      
        1 mfqvgrstes pidfvvtdti sgsqntdeaq itqstisrfa crivcdrnep ytarifaagf
       61 dsskniflge kaakwknpdg hmdglttngv lvmhprggft eesqpgvwre isvcgdvytl
      121 retrsaqqrg klvesetnvl qdgslidlcg atllwrtadg lfhtptqkhi ealrqeinaa
      181 rpqcpvglnt lafpsinrke vveekqpway lscghvhgyh nwghrsdtea nerecpmcrt
      241 vgpyvplwlg ceagfyvdag ppthaftpcg hvcseksaky wsqiplphgt hafhaacpfc
      301 atqlvgeqnc iklifqgpid
//
LOCUS       XP_005267947             247 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase pellino homolog 2 isoform X3 [Homo
            sapiens].
ACCESSION   XP_005267947
VERSION     XP_005267947.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267890.6
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..247
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..247
                     /product="E3 ubiquitin-protein ligase pellino homolog 2
                     isoform X3"
                     /calculated_mol_wt=27274
     Region          12..>232
                     /region_name="Pellino"
                     /note="pfam04710"
                     /db_xref="CDD:461403"
     CDS             1..247
                     /gene="PELI2"
                     /coded_by="XM_005267890.6:251..994"
                     /db_xref="GeneID:57161"
                     /db_xref="HGNC:HGNC:8828"
                     /db_xref="MIM:614798"
ORIGIN      
        1 mfspgqeehc apnkepvkyg elvvlgynga lpngdrgrrk srfalykrpk angvkpstvh
       61 vistpqaska isckgqhsis ytlsrnqtvv veythdkdtd mfqvgrstes pidfvvtdti
      121 sgsqntdeaq itqstisrfa crivcdrnep ytarifaagf dsskniflge kaakwknpdg
      181 hmdglttngv lvmhprggft eesqpgvwre isvcgdvytl retrsaqqrg klqmmepqnc
      241 vlinkin
//
LOCUS       XP_006720276             162 aa            linear   PRI 05-AUG-2025
DEFINITION  proteasome activator complex subunit 2 isoform X1 [Homo sapiens].
ACCESSION   XP_006720276
VERSION     XP_006720276.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720213.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..162
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..162
                     /product="proteasome activator complex subunit 2 isoform
                     X1"
                     /calculated_mol_wt=18419
     Region          16..160
                     /region_name="PA28_beta"
                     /note="Proteasome activator pa28 beta subunit; pfam02252"
                     /db_xref="CDD:460508"
     CDS             1..162
                     /gene="PSME2"
                     /gene_synonym="PA28B; PA28beta; REGbeta"
                     /coded_by="XM_006720213.3:385..873"
                     /db_xref="GeneID:5721"
                     /db_xref="HGNC:HGNC:9569"
                     /db_xref="MIM:602161"
ORIGIN      
        1 metdkqekke vhkcgflpgn ekvlsllalv kpevwtlkek cilvitwiqh lipkiedgnd
       61 fgvaiqekvl ervnavktkv eafqttisky fsergdavak askethvmdy ralvherdea
      121 aygelramvl dlrafyaely hiissnleki vnpkgeekps my
//
LOCUS       XP_005267948             359 aa            linear   PRI 05-AUG-2025
DEFINITION  prostaglandin D2 receptor isoform X1 [Homo sapiens].
ACCESSION   XP_005267948
VERSION     XP_005267948.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267891.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..359
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..359
                     /product="prostaglandin D2 receptor isoform X1"
                     /calculated_mol_wt=40140
     Region          17..335
                     /region_name="7tmA_PGD2"
                     /note="prostaglandin D2 receptor, member of the class A
                     family of seven-transmembrane G protein-coupled receptors;
                     cd15140"
                     /db_xref="CDD:320268"
     Region          18..44
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:320268"
     Region          61..87
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320268"
     Site            order(83,86..87,105..110,112..113,116,161,163..167,195,
                     198..200,202..204,206..207,278,281..282,284..285,288,
                     301..302,304..306,309,312..313)
                     /site_type="other"
                     /note="putative ligand binding pocket [chemical binding]"
                     /db_xref="CDD:320268"
     Region          105..135
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320268"
     Region          147..169
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320268"
     Region          195..224
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320268"
     Region          258..288
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320268"
     Region          302..327
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320268"
     CDS             1..359
                     /gene="PTGDR"
                     /gene_synonym="AS1; ASRT1; DP; DP1; PTGDR1"
                     /coded_by="XM_005267891.5:118..1197"
                     /db_xref="GeneID:5729"
                     /db_xref="HGNC:HGNC:9591"
                     /db_xref="MIM:604687"
ORIGIN      
        1 mkspfyrcqn ttsvekgnsa vmggvlfstg llgnllalgl larsglgwcs rrplrplpsv
       61 fymlvcgltv tdllgkclls pvvlaayaqn rslrvlapal dnslcqafaf fmsffglsst
      121 lqllamalec wlslghpffy rrhitlrlga lvapvvsafs lafcalpfmg fgkfvqycpg
      181 twcfiqmvhe egslsvlgys vlysslmall vlatvlcnlg amrnlyamhr rlqrhprsct
      241 rdcaepradg reaspqplee ldhllllalm tvlftmcslp viyrayygaf kdvkeknrts
      301 eeaedlralr flsvisivdp wifiifrspv friffhkifi rplryrsrcs nstnmessl
//
LOCUS       XP_047287569             186 aa            linear   PRI 05-AUG-2025
DEFINITION  rho-related GTP-binding protein RhoJ isoform X1 [Homo sapiens].
ACCESSION   XP_047287569
VERSION     XP_047287569.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431613.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..186
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..186
                     /product="rho-related GTP-binding protein RhoJ isoform X1"
                     /calculated_mol_wt=20629
     Region          22..165
                     /region_name="P-loop containing Nucleoside Triphosphate
                     Hydrolases"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; cl38936"
                     /db_xref="CDD:476819"
     Site            28..35
                     /site_type="other"
                     /note="G1 box"
                     /db_xref="CDD:206648"
     Site            53
                     /site_type="other"
                     /note="G2 box"
                     /db_xref="CDD:206648"
     Site            56..58
                     /site_type="other"
                     /note="Switch I region"
                     /db_xref="CDD:206648"
     Site            75..78
                     /site_type="other"
                     /note="G3 box"
                     /db_xref="CDD:206648"
     Site            order(77..78,94..95)
                     /site_type="other"
                     /note="Switch II region"
                     /db_xref="CDD:206648"
     Site            133..136
                     /site_type="other"
                     /note="G4 box"
                     /db_xref="CDD:206648"
     CDS             1..186
                     /gene="RHOJ"
                     /gene_synonym="ARHJ; RASL7B; TC10B; TCL"
                     /coded_by="XM_047431613.1:428..988"
                     /db_xref="GeneID:57381"
                     /db_xref="HGNC:HGNC:688"
                     /db_xref="MIM:607653"
ORIGIN      
        1 mnckegtdss cgcrgndekk mlkcvvvgdg avgktcllms yandafpeey vptvfdhyav
       61 tvtvggkqhl lglydtagqe dynqlrplsy pntdvflicf svvnpasyhn vqeewvpelk
      121 dcmphvpyvl igtqidlrdd pktlarllym kekpltyehg vklakakcln wkrqawappa
      181 pskgka
//
LOCUS       XP_011535295             159 aa            linear   PRI 05-AUG-2025
DEFINITION  rho-related GTP-binding protein RhoJ isoform X2 [Homo sapiens].
ACCESSION   XP_011535295
VERSION     XP_011535295.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011536993.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..159
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..159
                     /product="rho-related GTP-binding protein RhoJ isoform X2"
                     /calculated_mol_wt=17297
     Region          22..140
                     /region_name="P-loop containing Nucleoside Triphosphate
                     Hydrolases"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; cl38936"
                     /db_xref="CDD:476819"
     Site            28..35
                     /site_type="other"
                     /note="G1 box"
                     /db_xref="CDD:206707"
     Site            order(30..36,78,79,81,121..123)
                     /site_type="other"
                     /note="GTP/Mg2+ binding site [chemical binding]"
                     /db_xref="CDD:206707"
     Site            53
                     /site_type="other"
                     /note="G2 box"
                     /db_xref="CDD:206707"
     Site            56..58
                     /site_type="other"
                     /note="Switch I region"
                     /db_xref="CDD:206707"
     Site            75..78
                     /site_type="other"
                     /note="G3 box"
                     /db_xref="CDD:206707"
     Site            121..123
                     /site_type="other"
                     /note="G5 box"
                     /db_xref="CDD:206707"
     CDS             1..159
                     /gene="RHOJ"
                     /gene_synonym="ARHJ; RASL7B; TC10B; TCL"
                     /coded_by="XM_011536993.4:428..907"
                     /db_xref="GeneID:57381"
                     /db_xref="HGNC:HGNC:688"
                     /db_xref="MIM:607653"
ORIGIN      
        1 mnckegtdss cgcrgndekk mlkcvvvgdg avgktcllms yandafpeey vptvfdhyav
       61 tvtvggkqhl lglydtagqi dlrddpktla rllymkekpl tyehgvklak aigaqcylec
      121 saltqkglka vfdeailtif hpkkkkkrcs eghsccsii
//
LOCUS       XP_016876987             558 aa            linear   PRI 05-AUG-2025
DEFINITION  polypeptide N-acetylgalactosaminyltransferase 16 isoform X1 [Homo
            sapiens].
ACCESSION   XP_016876987
VERSION     XP_016876987.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021498.2
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 25% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..558
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..558
                     /product="polypeptide N-acetylgalactosaminyltransferase 16
                     isoform X1"
                     /calculated_mol_wt=62943
     Region          126..420
                     /region_name="pp-GalNAc-T"
                     /note="pp-GalNAc-T initiates the formation of mucin-type
                     O-linked glycans; cd02510"
                     /db_xref="CDD:133004"
     Site            order(130..132,134,163,188,191,195,211..213,294..295,
                     317..318,320,345,348,353)
                     /site_type="active"
                     /note="ligand binding site [active]"
                     /db_xref="CDD:133004"
     Site            order(211,213,345)
                     /site_type="active"
                     /note="Mn binding site [active]"
                     /db_xref="CDD:133004"
     Region          426..557
                     /region_name="beta-trefoil_Ricin_GALNT16"
                     /note="ricin B-type lectin domain, beta-trefoil fold,
                     found in polypeptide N-acetylgalactosaminyltransferase 16
                     (GALNT16) and similar proteins; cd23479"
                     /db_xref="CDD:467357"
     Site            order(443..445,456,458,461,470..471)
                     /site_type="other"
                     /note="putative sugar binding site [chemical binding]"
                     /db_xref="CDD:467357"
     Site            order(488..491,502,504,507,512..513)
                     /site_type="other"
                     /note="putative sugar binding site [chemical binding]"
                     /db_xref="CDD:467357"
     Site            order(532..535,539,541,544,549..550)
                     /site_type="other"
                     /note="putative sugar binding site [chemical binding]"
                     /db_xref="CDD:467357"
     CDS             1..558
                     /gene="GALNT16"
                     /gene_synonym="GalNAc-T16; GALNACT16; GALNTL1"
                     /coded_by="XM_017021498.2:230..1906"
                     /db_xref="GeneID:57452"
                     /db_xref="HGNC:HGNC:23233"
                     /db_xref="MIM:615132"
ORIGIN      
        1 mrkiranaia iltvawilgt fyylwqdnra haassggrga qragrrseql redrtipliv
       61 tgtpskgfde kaylsakqlk agedpyrqha fnqlesdkls pdrpirdtrh yscpsvsyss
      121 dlpatsviit fhnearstll rtvksvlnrt panliqeiil vddfssdped cllltripkv
      181 kclrndrreg lirsrvrgad vaaatvltfl dshcevntew lppmlqrvke dhtrvvspii
      241 dvisldnfay laasadlrgg fdwslhfkwe qipleqkmtr tdptrpirtp viaggifvid
      301 kswfnhlgky daqmdiwgge nfelsfrvwm cggsleivpc srvghvfrkr hpynfpegna
      361 ltyirntkrt aevwmdeykq yyyearpsai gkafgsvatr ieqrkkmnck sfrwylenvy
      421 peltvpvkea lpgiikqgvn clesqgqnta gdfllgmgic rgsaknpqpa qawlfsdhli
      481 qqqgkclaat stlmsspgsp vilqmcnpre gkqkwrrkgs fiqhsvsglc letkpaqlvt
      541 skcqadaqaq qwqllpht
//
LOCUS       XP_011535308             558 aa            linear   PRI 05-AUG-2025
DEFINITION  polypeptide N-acetylgalactosaminyltransferase 16 isoform X1 [Homo
            sapiens].
ACCESSION   XP_011535308
VERSION     XP_011535308.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537006.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..558
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..558
                     /product="polypeptide N-acetylgalactosaminyltransferase 16
                     isoform X1"
                     /calculated_mol_wt=62943
     Region          126..420
                     /region_name="pp-GalNAc-T"
                     /note="pp-GalNAc-T initiates the formation of mucin-type
                     O-linked glycans; cd02510"
                     /db_xref="CDD:133004"
     Site            order(130..132,134,163,188,191,195,211..213,294..295,
                     317..318,320,345,348,353)
                     /site_type="active"
                     /note="ligand binding site [active]"
                     /db_xref="CDD:133004"
     Site            order(211,213,345)
                     /site_type="active"
                     /note="Mn binding site [active]"
                     /db_xref="CDD:133004"
     Region          426..557
                     /region_name="beta-trefoil_Ricin_GALNT16"
                     /note="ricin B-type lectin domain, beta-trefoil fold,
                     found in polypeptide N-acetylgalactosaminyltransferase 16
                     (GALNT16) and similar proteins; cd23479"
                     /db_xref="CDD:467357"
     Site            order(443..445,456,458,461,470..471)
                     /site_type="other"
                     /note="putative sugar binding site [chemical binding]"
                     /db_xref="CDD:467357"
     Site            order(488..491,502,504,507,512..513)
                     /site_type="other"
                     /note="putative sugar binding site [chemical binding]"
                     /db_xref="CDD:467357"
     Site            order(532..535,539,541,544,549..550)
                     /site_type="other"
                     /note="putative sugar binding site [chemical binding]"
                     /db_xref="CDD:467357"
     CDS             1..558
                     /gene="GALNT16"
                     /gene_synonym="GalNAc-T16; GALNACT16; GALNTL1"
                     /coded_by="XM_011537006.4:134..1810"
                     /db_xref="GeneID:57452"
                     /db_xref="HGNC:HGNC:23233"
                     /db_xref="MIM:615132"
ORIGIN      
        1 mrkiranaia iltvawilgt fyylwqdnra haassggrga qragrrseql redrtipliv
       61 tgtpskgfde kaylsakqlk agedpyrqha fnqlesdkls pdrpirdtrh yscpsvsyss
      121 dlpatsviit fhnearstll rtvksvlnrt panliqeiil vddfssdped cllltripkv
      181 kclrndrreg lirsrvrgad vaaatvltfl dshcevntew lppmlqrvke dhtrvvspii
      241 dvisldnfay laasadlrgg fdwslhfkwe qipleqkmtr tdptrpirtp viaggifvid
      301 kswfnhlgky daqmdiwgge nfelsfrvwm cggsleivpc srvghvfrkr hpynfpegna
      361 ltyirntkrt aevwmdeykq yyyearpsai gkafgsvatr ieqrkkmnck sfrwylenvy
      421 peltvpvkea lpgiikqgvn clesqgqnta gdfllgmgic rgsaknpqpa qawlfsdhli
      481 qqqgkclaat stlmsspgsp vilqmcnpre gkqkwrrkgs fiqhsvsglc letkpaqlvt
      541 skcqadaqaq qwqllpht
//
LOCUS       XP_047287574             558 aa            linear   PRI 05-AUG-2025
DEFINITION  polypeptide N-acetylgalactosaminyltransferase 16 isoform X1 [Homo
            sapiens].
ACCESSION   XP_047287574
VERSION     XP_047287574.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431618.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..558
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..558
                     /product="polypeptide N-acetylgalactosaminyltransferase 16
                     isoform X1"
                     /calculated_mol_wt=62943
     Region          126..420
                     /region_name="pp-GalNAc-T"
                     /note="pp-GalNAc-T initiates the formation of mucin-type
                     O-linked glycans; cd02510"
                     /db_xref="CDD:133004"
     Site            order(130..132,134,163,188,191,195,211..213,294..295,
                     317..318,320,345,348,353)
                     /site_type="active"
                     /note="ligand binding site [active]"
                     /db_xref="CDD:133004"
     Site            order(211,213,345)
                     /site_type="active"
                     /note="Mn binding site [active]"
                     /db_xref="CDD:133004"
     Region          426..557
                     /region_name="beta-trefoil_Ricin_GALNT16"
                     /note="ricin B-type lectin domain, beta-trefoil fold,
                     found in polypeptide N-acetylgalactosaminyltransferase 16
                     (GALNT16) and similar proteins; cd23479"
                     /db_xref="CDD:467357"
     Site            order(443..445,456,458,461,470..471)
                     /site_type="other"
                     /note="putative sugar binding site [chemical binding]"
                     /db_xref="CDD:467357"
     Site            order(488..491,502,504,507,512..513)
                     /site_type="other"
                     /note="putative sugar binding site [chemical binding]"
                     /db_xref="CDD:467357"
     Site            order(532..535,539,541,544,549..550)
                     /site_type="other"
                     /note="putative sugar binding site [chemical binding]"
                     /db_xref="CDD:467357"
     CDS             1..558
                     /gene="GALNT16"
                     /gene_synonym="GalNAc-T16; GALNACT16; GALNTL1"
                     /coded_by="XM_047431618.1:134..1810"
                     /db_xref="GeneID:57452"
                     /db_xref="HGNC:HGNC:23233"
                     /db_xref="MIM:615132"
ORIGIN      
        1 mrkiranaia iltvawilgt fyylwqdnra haassggrga qragrrseql redrtipliv
       61 tgtpskgfde kaylsakqlk agedpyrqha fnqlesdkls pdrpirdtrh yscpsvsyss
      121 dlpatsviit fhnearstll rtvksvlnrt panliqeiil vddfssdped cllltripkv
      181 kclrndrreg lirsrvrgad vaaatvltfl dshcevntew lppmlqrvke dhtrvvspii
      241 dvisldnfay laasadlrgg fdwslhfkwe qipleqkmtr tdptrpirtp viaggifvid
      301 kswfnhlgky daqmdiwgge nfelsfrvwm cggsleivpc srvghvfrkr hpynfpegna
      361 ltyirntkrt aevwmdeykq yyyearpsai gkafgsvatr ieqrkkmnck sfrwylenvy
      421 peltvpvkea lpgiikqgvn clesqgqnta gdfllgmgic rgsaknpqpa qawlfsdhli
      481 qqqgkclaat stlmsspgsp vilqmcnpre gkqkwrrkgs fiqhsvsglc letkpaqlvt
      541 skcqadaqaq qwqllpht
//
LOCUS       XP_011535309             514 aa            linear   PRI 05-AUG-2025
DEFINITION  polypeptide N-acetylgalactosaminyltransferase 16 isoform X2 [Homo
            sapiens].
ACCESSION   XP_011535309
VERSION     XP_011535309.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537007.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..514
                     /product="polypeptide N-acetylgalactosaminyltransferase 16
                     isoform X2"
                     /calculated_mol_wt=57984
     Region          126..420
                     /region_name="pp-GalNAc-T"
                     /note="pp-GalNAc-T initiates the formation of mucin-type
                     O-linked glycans; cd02510"
                     /db_xref="CDD:133004"
     Site            order(130..132,134,163,188,191,195,211..213,294..295,
                     317..318,320,345,348,353)
                     /site_type="active"
                     /note="ligand binding site [active]"
                     /db_xref="CDD:133004"
     Site            order(211,213,345)
                     /site_type="active"
                     /note="Mn binding site [active]"
                     /db_xref="CDD:133004"
     Region          426..>514
                     /region_name="beta-trefoil_Ricin-like"
                     /note="ricin B-type lectin domain, beta-trefoil fold;
                     cl49609"
                     /db_xref="CDD:483949"
     Site            order(443..445,456,458,470..471)
                     /site_type="other"
                     /note="sugar binding site [chemical binding]"
                     /db_xref="CDD:467293"
     Site            order(488..489,502,504,512..513)
                     /site_type="other"
                     /note="sugar binding site [chemical binding]"
                     /db_xref="CDD:467293"
     CDS             1..514
                     /gene="GALNT16"
                     /gene_synonym="GalNAc-T16; GALNACT16; GALNTL1"
                     /coded_by="XM_011537007.4:134..1678"
                     /db_xref="GeneID:57452"
                     /db_xref="HGNC:HGNC:23233"
                     /db_xref="MIM:615132"
ORIGIN      
        1 mrkiranaia iltvawilgt fyylwqdnra haassggrga qragrrseql redrtipliv
       61 tgtpskgfde kaylsakqlk agedpyrqha fnqlesdkls pdrpirdtrh yscpsvsyss
      121 dlpatsviit fhnearstll rtvksvlnrt panliqeiil vddfssdped cllltripkv
      181 kclrndrreg lirsrvrgad vaaatvltfl dshcevntew lppmlqrvke dhtrvvspii
      241 dvisldnfay laasadlrgg fdwslhfkwe qipleqkmtr tdptrpirtp viaggifvid
      301 kswfnhlgky daqmdiwgge nfelsfrvwm cggsleivpc srvghvfrkr hpynfpegna
      361 ltyirntkrt aevwmdeykq yyyearpsai gkafgsvatr ieqrkkmnck sfrwylenvy
      421 peltvpvkea lpgiikqgvn clesqgqnta gdfllgmgic rgsaknpqpa qawlfsdhli
      481 qqqgkclaat stlmsspgsp vilqmcnpre gkqk
//
LOCUS       XP_011535311            1392 aa            linear   PRI 05-AUG-2025
DEFINITION  pleckstrin homology domain-containing family H member 1 isoform X1
            [Homo sapiens].
ACCESSION   XP_011535311
VERSION     XP_011535311.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537009.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1392
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1392
                     /product="pleckstrin homology domain-containing family H
                     member 1 isoform X1"
                     /calculated_mol_wt=154378
     Region          20..>171
                     /region_name="DR0291"
                     /note="Predicted nucleic acid-binding protein DR0291,
                     contains C4-type Zn-ribbon domain [General function
                     prediction only]; COG1579"
                     /db_xref="CDD:441187"
     Region          581..676
                     /region_name="PH1_PLEKHH1_PLEKHH2"
                     /note="Pleckstrin homology (PH) domain containing, family
                     H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain,
                     repeat 1; cd13282"
                     /db_xref="CDD:241436"
     Region          860..1014
                     /region_name="MyTH4"
                     /note="Domain in Myosin and Kinesin Tails; smart00139"
                     /db_xref="CDD:214535"
     Region          1024..1130
                     /region_name="Ubl1_cv_Nsp3_N-like"
                     /note="first ubiquitin-like (Ubl) domain located at the
                     N-terminus of coronavirus SARS-CoV non-structural protein
                     3 (Nsp3) and related proteins; cl28922"
                     /db_xref="CDD:475130"
     Region          1027..1258
                     /region_name="B41"
                     /note="Band 4.1 homologues; smart00295"
                     /db_xref="CDD:214604"
     Region          1254..1356
                     /region_name="FERM_C-lobe_PLEKHH1_PLEKHH2"
                     /note="FERM domain C-lobe of Pleckstrin homology
                     domain-containing family H; cd13206"
                     /db_xref="CDD:241360"
     Site            order(1262,1284,1286,1294)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:241360"
     Site            order(1298,1303..1306,1344,1348,1351..1352,1355)
                     /site_type="other"
                     /note="TSLC1 peptide binding site [polypeptide binding]"
                     /db_xref="CDD:241360"
     Site            1344..1355
                     /site_type="other"
                     /note="putative actin binding site 2 [polypeptide
                     binding]"
                     /db_xref="CDD:241360"
     CDS             1..1392
                     /gene="PLEKHH1"
                     /coded_by="XM_011537009.2:144..4322"
                     /db_xref="GeneID:57475"
                     /db_xref="HGNC:HGNC:17733"
ORIGIN      
        1 maelkveapa svdwqkrclt letqlfrfrl qaskirella dkmqeleqrl leaeqraena
       61 etqvgvmeek vklsnlknvd segslhrkyq ellkaikgkd elisqleaql ekqkqmraee
      121 aktvqekaak ikewvtlkla klemenqhlk shnqrlveqv gslqdaleai qiapsrkllv
      181 ppygaaeqds vpsepgiqpm gqdsgsqaqg lkaavlapsp galqskdsvs eaaspledss
      241 sstvhsgetv eakplqphlg respphqpcm klltfrcssa swgeglvtaq rgmlpgtkts
      301 areggpgssl tlpkvrapgt prdsiqlakr hhsqpqvghg hfgrvvniet eafsalhpsg
      361 lpelesrars reepekmeme epppagknee respkalgae leevelgnkp ptpplhqfss
      421 wesriyavat sgmrlsdmsp rsntaccass ppalvspgsf sglvyknvtv pvytalkgra
      481 tqisnmpfmd essgsdddcs sqasfrisvp ssesrktsgl gspraikrgv smsslssegd
      541 yaippdacsl dsdysepehk lqrtssystd glglggesle ksgyllkmgs qvktwkrrwf
      601 vlrqgqimyy kspsdvirkp qgqvdlnsrc qivrgegsqt fqlisekkty yltadspsll
      661 eewirvlqsl lkvqatgppa llrggtkptv kgwltkvkhg hskvvwcalv gkifyyyrsh
      721 edklhgayvf rerrlphppl alpfmedccp qrplgclpvr dahieevdrs cdsdedyeag
      781 gtrrllsshc tlvihptehs ptylligtkh ekdtwlyhlt vaaggssakv gtayeqligk
      841 lmdgegdpds plwrhpmlcy skdglyaslt tlpsealqte alklfkscql finvpveaas
      901 vdyhvslaqt alqvclvhpe lqseiycqlm kqtscrppqk yslmqcwqll alcaplflpq
      961 hhflwyvkqq lqrhadprse tgqyatycqr avertlrtge rearpsrmev vsillrnpfh
     1021 hslpfsipvh ftngtyhvvg fdgsstvdef lqrlnqeigm rkpshsgfal ftddpsgrdl
     1081 ehclqgsvki cdaiskweqa mkelhpgkse ggtrvvklmy knrlyfrsqv kgetdrerll
     1141 lasqtsreiv agrfpinkel alemaalmaq veygdlekpa lpgpggtspa kaqhllqqvl
     1201 drfhprryrh gapaeqlrhl admlttkwat lqgcsppeci riyltvarkw pffgaklfaa
     1261 qpaqlssken alvwiavned gvsildhntm qvhitypyss vttfggcrdd fmlvirsipd
     1321 kssgkshiek lifrmaapki aeatfimasy mnhctttvnp ptnppgacql weldgrqffs
     1381 svscatkgpt ll
//
LOCUS       XP_016876988            1371 aa            linear   PRI 05-AUG-2025
DEFINITION  pleckstrin homology domain-containing family H member 1 isoform X2
            [Homo sapiens].
ACCESSION   XP_016876988
VERSION     XP_016876988.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021499.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1371
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1371
                     /product="pleckstrin homology domain-containing family H
                     member 1 isoform X2"
                     /calculated_mol_wt=151879
     Region          <21..>150
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          <69..>245
                     /region_name="CwlO1"
                     /note="Uncharacterized N-terminal coiled-coil domain of
                     peptidoglycan hydrolase CwlO [Function unknown]; COG3883"
                     /db_xref="CDD:443091"
     Region          560..655
                     /region_name="PH1_PLEKHH1_PLEKHH2"
                     /note="Pleckstrin homology (PH) domain containing, family
                     H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain,
                     repeat 1; cd13282"
                     /db_xref="CDD:241436"
     Region          839..993
                     /region_name="MyTH4"
                     /note="Domain in Myosin and Kinesin Tails; smart00139"
                     /db_xref="CDD:214535"
     Region          1003..1109
                     /region_name="Ubl1_cv_Nsp3_N-like"
                     /note="first ubiquitin-like (Ubl) domain located at the
                     N-terminus of coronavirus SARS-CoV non-structural protein
                     3 (Nsp3) and related proteins; cl28922"
                     /db_xref="CDD:475130"
     Region          1006..1237
                     /region_name="B41"
                     /note="Band 4.1 homologues; smart00295"
                     /db_xref="CDD:214604"
     Region          1233..1335
                     /region_name="FERM_C-lobe_PLEKHH1_PLEKHH2"
                     /note="FERM domain C-lobe of Pleckstrin homology
                     domain-containing family H; cd13206"
                     /db_xref="CDD:241360"
     Site            order(1241,1263,1265,1273)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:241360"
     Site            order(1277,1282..1285,1323,1327,1330..1331,1334)
                     /site_type="other"
                     /note="TSLC1 peptide binding site [polypeptide binding]"
                     /db_xref="CDD:241360"
     Site            1323..1334
                     /site_type="other"
                     /note="putative actin binding site 2 [polypeptide
                     binding]"
                     /db_xref="CDD:241360"
     CDS             1..1371
                     /gene="PLEKHH1"
                     /coded_by="XM_017021499.2:144..4259"
                     /db_xref="GeneID:57475"
                     /db_xref="HGNC:HGNC:17733"
ORIGIN      
        1 maelkveapa svdwqkrclt letqlfrfrl qaskirella dkvgvmeekv klsnlknvds
       61 egslhrkyqe llkaikgkde lisqleaqle kqkqmraeea ktvqekaaki kewvtlklak
      121 lemenqhlks hnqrlveqvg slqdaleaiq iapsrkllvp pygaaeqdsv psepgiqpmg
      181 qdsgsqaqgl kaavlapspg alqskdsvse aaspledsss stvhsgetve akplqphlgr
      241 espphqpcmk lltfrcssas wgeglvtaqr gmlpgtktsa reggpgsslt lpkvrapgtp
      301 rdsiqlakrh hsqpqvghgh fgrvvniete afsalhpsgl pelesrarsr eepekmemee
      361 pppagkneer espkalgael eevelgnkpp tpplhqfssw esriyavats gmrlsdmspr
      421 sntaccassp palvspgsfs glvyknvtvp vytalkgrat qisnmpfmde ssgsdddcss
      481 qasfrisvps sesrktsglg spraikrgvs msslssegdy aippdacsld sdysepehkl
      541 qrtssystdg lglggeslek sgyllkmgsq vktwkrrwfv lrqgqimyyk spsdvirkpq
      601 gqvdlnsrcq ivrgegsqtf qlisekktyy ltadspslle ewirvlqsll kvqatgppal
      661 lrggtkptvk gwltkvkhgh skvvwcalvg kifyyyrshe dklhgayvfr errlphppla
      721 lpfmedccpq rplgclpvrd ahieevdrsc dsdedyeagg trrllsshct lvihptehsp
      781 tylligtkhe kdtwlyhltv aaggssakvg tayeqligkl mdgegdpdsp lwrhpmlcys
      841 kdglyasltt lpsealqtea lklfkscqlf invpveaasv dyhvslaqta lqvclvhpel
      901 qseiycqlmk qtscrppqky slmqcwqlla lcaplflpqh hflwyvkqql qrhadprset
      961 gqyatycqra vertlrtger earpsrmevv sillrnpfhh slpfsipvhf tngtyhvvgf
     1021 dgsstvdefl qrlnqeigmr kpshsgfalf tddpsgrdle hclqgsvkic daiskweqam
     1081 kelhpgkseg gtrvvklmyk nrlyfrsqvk getdrerlll asqtsreiva grfpinkela
     1141 lemaalmaqv eygdlekpal pgpggtspak aqhllqqvld rfhprryrhg apaeqlrhla
     1201 dmlttkwatl qgcsppecir iyltvarkwp ffgaklfaaq paqlsskena lvwiavnedg
     1261 vsildhntmq vhitypyssv ttfggcrddf mlvirsipdk ssgkshiekl ifrmaapkia
     1321 eatfimasym nhctttvnpp tnppgacqlw eldgrqffss vscatkgptl l
//
LOCUS       XP_016876989            1364 aa            linear   PRI 05-AUG-2025
DEFINITION  pleckstrin homology domain-containing family H member 1 isoform X3
            [Homo sapiens].
ACCESSION   XP_016876989
VERSION     XP_016876989.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021500.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1364
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1364
                     /product="pleckstrin homology domain-containing family H
                     member 1 isoform X3"
                     /calculated_mol_wt=151165
     Region          20..>171
                     /region_name="DR0291"
                     /note="Predicted nucleic acid-binding protein DR0291,
                     contains C4-type Zn-ribbon domain [General function
                     prediction only]; COG1579"
                     /db_xref="CDD:441187"
     Region          581..676
                     /region_name="PH1_PLEKHH1_PLEKHH2"
                     /note="Pleckstrin homology (PH) domain containing, family
                     H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain,
                     repeat 1; cd13282"
                     /db_xref="CDD:241436"
     Region          860..1013
                     /region_name="MyTH4"
                     /note="Domain in Myosin and Kinesin Tails; smart00139"
                     /db_xref="CDD:214535"
     Region          1008..1230
                     /region_name="B41"
                     /note="Band 4.1 homologues; smart00295"
                     /db_xref="CDD:214604"
     Region          1009..1102
                     /region_name="Ubl1_cv_Nsp3_N-like"
                     /note="first ubiquitin-like (Ubl) domain located at the
                     N-terminus of coronavirus SARS-CoV non-structural protein
                     3 (Nsp3) and related proteins; cl28922"
                     /db_xref="CDD:475130"
     Region          1226..1328
                     /region_name="FERM_C-lobe_PLEKHH1_PLEKHH2"
                     /note="FERM domain C-lobe of Pleckstrin homology
                     domain-containing family H; cd13206"
                     /db_xref="CDD:241360"
     Site            order(1234,1256,1258,1266)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:241360"
     Site            order(1270,1275..1278,1316,1320,1323..1324,1327)
                     /site_type="other"
                     /note="TSLC1 peptide binding site [polypeptide binding]"
                     /db_xref="CDD:241360"
     Site            1316..1327
                     /site_type="other"
                     /note="putative actin binding site 2 [polypeptide
                     binding]"
                     /db_xref="CDD:241360"
     CDS             1..1364
                     /gene="PLEKHH1"
                     /coded_by="XM_017021500.2:144..4238"
                     /db_xref="GeneID:57475"
                     /db_xref="HGNC:HGNC:17733"
ORIGIN      
        1 maelkveapa svdwqkrclt letqlfrfrl qaskirella dkmqeleqrl leaeqraena
       61 etqvgvmeek vklsnlknvd segslhrkyq ellkaikgkd elisqleaql ekqkqmraee
      121 aktvqekaak ikewvtlkla klemenqhlk shnqrlveqv gslqdaleai qiapsrkllv
      181 ppygaaeqds vpsepgiqpm gqdsgsqaqg lkaavlapsp galqskdsvs eaaspledss
      241 sstvhsgetv eakplqphlg respphqpcm klltfrcssa swgeglvtaq rgmlpgtkts
      301 areggpgssl tlpkvrapgt prdsiqlakr hhsqpqvghg hfgrvvniet eafsalhpsg
      361 lpelesrars reepekmeme epppagknee respkalgae leevelgnkp ptpplhqfss
      421 wesriyavat sgmrlsdmsp rsntaccass ppalvspgsf sglvyknvtv pvytalkgra
      481 tqisnmpfmd essgsdddcs sqasfrisvp ssesrktsgl gspraikrgv smsslssegd
      541 yaippdacsl dsdysepehk lqrtssystd glglggesle ksgyllkmgs qvktwkrrwf
      601 vlrqgqimyy kspsdvirkp qgqvdlnsrc qivrgegsqt fqlisekkty yltadspsll
      661 eewirvlqsl lkvqatgppa llrggtkptv kgwltkvkhg hskvvwcalv gkifyyyrsh
      721 edklhgayvf rerrlphppl alpfmedccp qrplgclpvr dahieevdrs cdsdedyeag
      781 gtrrllsshc tlvihptehs ptylligtkh ekdtwlyhlt vaaggssakv gtayeqligk
      841 lmdgegdpds plwrhpmlcy skdglyaslt tlpsealqte alklfkscql finvpveaas
      901 vdyhvslaqt alqvclvhpe lqseiycqlm kqtscrppqk yslmqcwqll alcaplflpq
      961 hhflwyvkqq lqrhadprse tgqyatycqr avertlrtge rearpsrmev vgfdgsstvd
     1021 eflqrlnqei gmrkpshsgf alftddpsgr dlehclqgsv kicdaiskwe qamkelhpgk
     1081 seggtrvvkl myknrlyfrs qvkgetdrer lllasqtsre ivagrfpink elalemaalm
     1141 aqveygdlek palpgpggts pakaqhllqq vldrfhprry rhgapaeqlr hladmlttkw
     1201 atlqgcsppe ciriyltvar kwpffgaklf aaqpaqlssk enalvwiavn edgvsildhn
     1261 tmqvhitypy ssvttfggcr ddfmlvirsi pdkssgkshi eklifrmaap kiaeatfima
     1321 symnhctttv npptnppgac qlweldgrqf fssvscatkg ptll
//
LOCUS       XP_016876990            1343 aa            linear   PRI 05-AUG-2025
DEFINITION  pleckstrin homology domain-containing family H member 1 isoform X4
            [Homo sapiens].
ACCESSION   XP_016876990
VERSION     XP_016876990.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021501.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1343
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1343
                     /product="pleckstrin homology domain-containing family H
                     member 1 isoform X4"
                     /calculated_mol_wt=148603
     Region          <21..>150
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          <69..>245
                     /region_name="CwlO1"
                     /note="Uncharacterized N-terminal coiled-coil domain of
                     peptidoglycan hydrolase CwlO [Function unknown]; COG3883"
                     /db_xref="CDD:443091"
     Region          560..655
                     /region_name="PH1_PLEKHH1_PLEKHH2"
                     /note="Pleckstrin homology (PH) domain containing, family
                     H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain,
                     repeat 1; cd13282"
                     /db_xref="CDD:241436"
     Region          667..770
                     /region_name="PH"
                     /note="Pleckstrin homology domain; smart00233"
                     /db_xref="CDD:214574"
     Region          811..965
                     /region_name="MyTH4"
                     /note="Domain in Myosin and Kinesin Tails; smart00139"
                     /db_xref="CDD:214535"
     Region          975..1081
                     /region_name="Ubl1_cv_Nsp3_N-like"
                     /note="first ubiquitin-like (Ubl) domain located at the
                     N-terminus of coronavirus SARS-CoV non-structural protein
                     3 (Nsp3) and related proteins; cl28922"
                     /db_xref="CDD:475130"
     Region          978..1209
                     /region_name="B41"
                     /note="Band 4.1 homologues; smart00295"
                     /db_xref="CDD:214604"
     Region          1205..1307
                     /region_name="FERM_C-lobe_PLEKHH1_PLEKHH2"
                     /note="FERM domain C-lobe of Pleckstrin homology
                     domain-containing family H; cd13206"
                     /db_xref="CDD:241360"
     Site            order(1213,1235,1237,1245)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:241360"
     Site            order(1249,1254..1257,1295,1299,1302..1303,1306)
                     /site_type="other"
                     /note="TSLC1 peptide binding site [polypeptide binding]"
                     /db_xref="CDD:241360"
     Site            1295..1306
                     /site_type="other"
                     /note="putative actin binding site 2 [polypeptide
                     binding]"
                     /db_xref="CDD:241360"
     CDS             1..1343
                     /gene="PLEKHH1"
                     /coded_by="XM_017021501.2:144..4175"
                     /db_xref="GeneID:57475"
                     /db_xref="HGNC:HGNC:17733"
ORIGIN      
        1 maelkveapa svdwqkrclt letqlfrfrl qaskirella dkvgvmeekv klsnlknvds
       61 egslhrkyqe llkaikgkde lisqleaqle kqkqmraeea ktvqekaaki kewvtlklak
      121 lemenqhlks hnqrlveqvg slqdaleaiq iapsrkllvp pygaaeqdsv psepgiqpmg
      181 qdsgsqaqgl kaavlapspg alqskdsvse aaspledsss stvhsgetve akplqphlgr
      241 espphqpcmk lltfrcssas wgeglvtaqr gmlpgtktsa reggpgsslt lpkvrapgtp
      301 rdsiqlakrh hsqpqvghgh fgrvvniete afsalhpsgl pelesrarsr eepekmemee
      361 pppagkneer espkalgael eevelgnkpp tpplhqfssw esriyavats gmrlsdmspr
      421 sntaccassp palvspgsfs glvyknvtvp vytalkgrat qisnmpfmde ssgsdddcss
      481 qasfrisvps sesrktsglg spraikrgvs msslssegdy aippdacsld sdysepehkl
      541 qrtssystdg lglggeslek sgyllkmgsq vktwkrrwfv lrqgqimyyk spsdvirkpq
      601 gqvdlnsrcq ivrgegsqtf qlisekktyy ltadspslle ewirvlqsll kvqatgppal
      661 lrggtkptvk gwltkvkhgh skvvwcalvg kifyyyrshe dkrplgclpv rdahieevdr
      721 scdsdedyea ggtrrllssh ctlvihpteh sptylligtk hekdtwlyhl tvaaggssak
      781 vgtayeqlig klmdgegdpd splwrhpmlc yskdglyasl ttlpsealqt ealklfkscq
      841 lfinvpveaa svdyhvslaq talqvclvhp elqseiycql mkqtscrppq kyslmqcwql
      901 lalcaplflp qhhflwyvkq qlqrhadprs etgqyatycq ravertlrtg erearpsrme
      961 vvsillrnpf hhslpfsipv hftngtyhvv gfdgsstvde flqrlnqeig mrkpshsgfa
     1021 lftddpsgrd lehclqgsvk icdaiskweq amkelhpgks eggtrvvklm yknrlyfrsq
     1081 vkgetdrerl llasqtsrei vagrfpinke lalemaalma qveygdlekp alpgpggtsp
     1141 akaqhllqqv ldrfhprryr hgapaeqlrh ladmlttkwa tlqgcsppec iriyltvark
     1201 wpffgaklfa aqpaqlsske nalvwiavne dgvsildhnt mqvhitypys svttfggcrd
     1261 dfmlvirsip dkssgkshie klifrmaapk iaeatfimas ymnhctttvn pptnppgacq
     1321 lweldgrqff ssvscatkgp tll
//
LOCUS       XP_047287575            1340 aa            linear   PRI 05-AUG-2025
DEFINITION  pleckstrin homology domain-containing family H member 1 isoform X5
            [Homo sapiens].
ACCESSION   XP_047287575
VERSION     XP_047287575.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431619.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1340
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1340
                     /product="pleckstrin homology domain-containing family H
                     member 1 isoform X5"
                     /calculated_mol_wt=148763
     Region          20..>171
                     /region_name="DR0291"
                     /note="Predicted nucleic acid-binding protein DR0291,
                     contains C4-type Zn-ribbon domain [General function
                     prediction only]; COG1579"
                     /db_xref="CDD:441187"
     Region          581..676
                     /region_name="PH1_PLEKHH1_PLEKHH2"
                     /note="Pleckstrin homology (PH) domain containing, family
                     H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain,
                     repeat 1; cd13282"
                     /db_xref="CDD:241436"
     Region          860..1014
                     /region_name="MyTH4"
                     /note="Domain in Myosin and Kinesin Tails; smart00139"
                     /db_xref="CDD:214535"
     Region          1024..1130
                     /region_name="Ubl1_cv_Nsp3_N-like"
                     /note="first ubiquitin-like (Ubl) domain located at the
                     N-terminus of coronavirus SARS-CoV non-structural protein
                     3 (Nsp3) and related proteins; cl28922"
                     /db_xref="CDD:475130"
     Region          1027..1258
                     /region_name="B41"
                     /note="Band 4.1 homologues; smart00295"
                     /db_xref="CDD:214604"
     Region          1254..1339
                     /region_name="PH-like"
                     /note="Pleckstrin homology-like domain; cl17171"
                     /db_xref="CDD:473070"
     CDS             1..1340
                     /gene="PLEKHH1"
                     /coded_by="XM_047431619.1:144..4166"
                     /db_xref="GeneID:57475"
                     /db_xref="HGNC:HGNC:17733"
ORIGIN      
        1 maelkveapa svdwqkrclt letqlfrfrl qaskirella dkmqeleqrl leaeqraena
       61 etqvgvmeek vklsnlknvd segslhrkyq ellkaikgkd elisqleaql ekqkqmraee
      121 aktvqekaak ikewvtlkla klemenqhlk shnqrlveqv gslqdaleai qiapsrkllv
      181 ppygaaeqds vpsepgiqpm gqdsgsqaqg lkaavlapsp galqskdsvs eaaspledss
      241 sstvhsgetv eakplqphlg respphqpcm klltfrcssa swgeglvtaq rgmlpgtkts
      301 areggpgssl tlpkvrapgt prdsiqlakr hhsqpqvghg hfgrvvniet eafsalhpsg
      361 lpelesrars reepekmeme epppagknee respkalgae leevelgnkp ptpplhqfss
      421 wesriyavat sgmrlsdmsp rsntaccass ppalvspgsf sglvyknvtv pvytalkgra
      481 tqisnmpfmd essgsdddcs sqasfrisvp ssesrktsgl gspraikrgv smsslssegd
      541 yaippdacsl dsdysepehk lqrtssystd glglggesle ksgyllkmgs qvktwkrrwf
      601 vlrqgqimyy kspsdvirkp qgqvdlnsrc qivrgegsqt fqlisekkty yltadspsll
      661 eewirvlqsl lkvqatgppa llrggtkptv kgwltkvkhg hskvvwcalv gkifyyyrsh
      721 edklhgayvf rerrlphppl alpfmedccp qrplgclpvr dahieevdrs cdsdedyeag
      781 gtrrllsshc tlvihptehs ptylligtkh ekdtwlyhlt vaaggssakv gtayeqligk
      841 lmdgegdpds plwrhpmlcy skdglyaslt tlpsealqte alklfkscql finvpveaas
      901 vdyhvslaqt alqvclvhpe lqseiycqlm kqtscrppqk yslmqcwqll alcaplflpq
      961 hhflwyvkqq lqrhadprse tgqyatycqr avertlrtge rearpsrmev vsillrnpfh
     1021 hslpfsipvh ftngtyhvvg fdgsstvdef lqrlnqeigm rkpshsgfal ftddpsgrdl
     1081 ehclqgsvki cdaiskweqa mkelhpgkse ggtrvvklmy knrlyfrsqv kgetdrerll
     1141 lasqtsreiv agrfpinkel alemaalmaq veygdlekpa lpgpggtspa kaqhllqqvl
     1201 drfhprryrh gapaeqlrhl admlttkwat lqgcsppeci riyltvarkw pffgaklfaa
     1261 qpaqlssken alvwiavned gvsildhntm qvhitypyss vttfggcrdd fmlvirsipd
     1321 kssgkshiek lifrmaapks
//
LOCUS       XP_047287576            1336 aa            linear   PRI 05-AUG-2025
DEFINITION  pleckstrin homology domain-containing family H member 1 isoform X6
            [Homo sapiens].
ACCESSION   XP_047287576
VERSION     XP_047287576.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431620.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1336
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1336
                     /product="pleckstrin homology domain-containing family H
                     member 1 isoform X6"
                     /calculated_mol_wt=147889
     Region          20..>171
                     /region_name="DR0291"
                     /note="Predicted nucleic acid-binding protein DR0291,
                     contains C4-type Zn-ribbon domain [General function
                     prediction only]; COG1579"
                     /db_xref="CDD:441187"
     Region          581..676
                     /region_name="PH1_PLEKHH1_PLEKHH2"
                     /note="Pleckstrin homology (PH) domain containing, family
                     H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain,
                     repeat 1; cd13282"
                     /db_xref="CDD:241436"
     Region          688..791
                     /region_name="PH"
                     /note="Pleckstrin homology domain; smart00233"
                     /db_xref="CDD:214574"
     Region          832..985
                     /region_name="MyTH4"
                     /note="Domain in Myosin and Kinesin Tails; smart00139"
                     /db_xref="CDD:214535"
     Region          980..1202
                     /region_name="B41"
                     /note="Band 4.1 homologues; smart00295"
                     /db_xref="CDD:214604"
     Region          981..1074
                     /region_name="Ubl1_cv_Nsp3_N-like"
                     /note="first ubiquitin-like (Ubl) domain located at the
                     N-terminus of coronavirus SARS-CoV non-structural protein
                     3 (Nsp3) and related proteins; cl28922"
                     /db_xref="CDD:475130"
     Region          1198..1300
                     /region_name="FERM_C-lobe_PLEKHH1_PLEKHH2"
                     /note="FERM domain C-lobe of Pleckstrin homology
                     domain-containing family H; cd13206"
                     /db_xref="CDD:241360"
     Site            order(1206,1228,1230,1238)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:241360"
     Site            order(1242,1247..1250,1288,1292,1295..1296,1299)
                     /site_type="other"
                     /note="TSLC1 peptide binding site [polypeptide binding]"
                     /db_xref="CDD:241360"
     Site            1288..1299
                     /site_type="other"
                     /note="putative actin binding site 2 [polypeptide
                     binding]"
                     /db_xref="CDD:241360"
     CDS             1..1336
                     /gene="PLEKHH1"
                     /coded_by="XM_047431620.1:144..4154"
                     /db_xref="GeneID:57475"
                     /db_xref="HGNC:HGNC:17733"
ORIGIN      
        1 maelkveapa svdwqkrclt letqlfrfrl qaskirella dkmqeleqrl leaeqraena
       61 etqvgvmeek vklsnlknvd segslhrkyq ellkaikgkd elisqleaql ekqkqmraee
      121 aktvqekaak ikewvtlkla klemenqhlk shnqrlveqv gslqdaleai qiapsrkllv
      181 ppygaaeqds vpsepgiqpm gqdsgsqaqg lkaavlapsp galqskdsvs eaaspledss
      241 sstvhsgetv eakplqphlg respphqpcm klltfrcssa swgeglvtaq rgmlpgtkts
      301 areggpgssl tlpkvrapgt prdsiqlakr hhsqpqvghg hfgrvvniet eafsalhpsg
      361 lpelesrars reepekmeme epppagknee respkalgae leevelgnkp ptpplhqfss
      421 wesriyavat sgmrlsdmsp rsntaccass ppalvspgsf sglvyknvtv pvytalkgra
      481 tqisnmpfmd essgsdddcs sqasfrisvp ssesrktsgl gspraikrgv smsslssegd
      541 yaippdacsl dsdysepehk lqrtssystd glglggesle ksgyllkmgs qvktwkrrwf
      601 vlrqgqimyy kspsdvirkp qgqvdlnsrc qivrgegsqt fqlisekkty yltadspsll
      661 eewirvlqsl lkvqatgppa llrggtkptv kgwltkvkhg hskvvwcalv gkifyyyrsh
      721 edkrplgclp vrdahieevd rscdsdedye aggtrrllss hctlvihpte hsptylligt
      781 khekdtwlyh ltvaaggssa kvgtayeqli gklmdgegdp dsplwrhpml cyskdglyas
      841 lttlpsealq tealklfksc qlfinvpvea asvdyhvsla qtalqvclvh pelqseiycq
      901 lmkqtscrpp qkyslmqcwq llalcaplfl pqhhflwyvk qqlqrhadpr setgqyatyc
      961 qravertlrt gerearpsrm evvgfdgsst vdeflqrlnq eigmrkpshs gfalftddps
     1021 grdlehclqg svkicdaisk weqamkelhp gkseggtrvv klmyknrlyf rsqvkgetdr
     1081 erlllasqts reivagrfpi nkelalemaa lmaqveygdl ekpalpgpgg tspakaqhll
     1141 qqvldrfhpr ryrhgapaeq lrhladmltt kwatlqgcsp peciriyltv arkwpffgak
     1201 lfaaqpaqls skenalvwia vnedgvsild hntmqvhity pyssvttfgg crddfmlvir
     1261 sipdkssgks hieklifrma apkiaeatfi masymnhctt tvnpptnppg acqlweldgr
     1321 qffssvscat kgptll
//
LOCUS       XP_016876991             952 aa            linear   PRI 05-AUG-2025
DEFINITION  pleckstrin homology domain-containing family H member 1 isoform X7
            [Homo sapiens].
ACCESSION   XP_016876991
VERSION     XP_016876991.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021502.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..952
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..952
                     /product="pleckstrin homology domain-containing family H
                     member 1 isoform X7"
                     /calculated_mol_wt=106234
     Region          141..236
                     /region_name="PH1_PLEKHH1_PLEKHH2"
                     /note="Pleckstrin homology (PH) domain containing, family
                     H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain,
                     repeat 1; cd13282"
                     /db_xref="CDD:241436"
     Region          420..574
                     /region_name="MyTH4"
                     /note="Domain in Myosin and Kinesin Tails; smart00139"
                     /db_xref="CDD:214535"
     Region          584..690
                     /region_name="Ubl1_cv_Nsp3_N-like"
                     /note="first ubiquitin-like (Ubl) domain located at the
                     N-terminus of coronavirus SARS-CoV non-structural protein
                     3 (Nsp3) and related proteins; cl28922"
                     /db_xref="CDD:475130"
     Region          587..818
                     /region_name="B41"
                     /note="Band 4.1 homologues; smart00295"
                     /db_xref="CDD:214604"
     Region          814..916
                     /region_name="FERM_C-lobe_PLEKHH1_PLEKHH2"
                     /note="FERM domain C-lobe of Pleckstrin homology
                     domain-containing family H; cd13206"
                     /db_xref="CDD:241360"
     Site            order(822,844,846,854)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:241360"
     Site            order(858,863..866,904,908,911..912,915)
                     /site_type="other"
                     /note="TSLC1 peptide binding site [polypeptide binding]"
                     /db_xref="CDD:241360"
     Site            904..915
                     /site_type="other"
                     /note="putative actin binding site 2 [polypeptide
                     binding]"
                     /db_xref="CDD:241360"
     CDS             1..952
                     /gene="PLEKHH1"
                     /coded_by="XM_017021502.2:2068..4926"
                     /db_xref="GeneID:57475"
                     /db_xref="HGNC:HGNC:17733"
ORIGIN      
        1 meekmvkass ppalvspgsf sglvyknvtv pvytalkgra tqisnmpfmd essgsdddcs
       61 sqasfrisvp ssesrktsgl gspraikrgv smsslssegd yaippdacsl dsdysepehk
      121 lqrtssystd glglggesle ksgyllkmgs qvktwkrrwf vlrqgqimyy kspsdvirkp
      181 qgqvdlnsrc qivrgegsqt fqlisekkty yltadspsll eewirvlqsl lkvqatgppa
      241 llrggtkptv kgwltkvkhg hskvvwcalv gkifyyyrsh edklhgayvf rerrlphppl
      301 alpfmedccp qrplgclpvr dahieevdrs cdsdedyeag gtrrllsshc tlvihptehs
      361 ptylligtkh ekdtwlyhlt vaaggssakv gtayeqligk lmdgegdpds plwrhpmlcy
      421 skdglyaslt tlpsealqte alklfkscql finvpveaas vdyhvslaqt alqvclvhpe
      481 lqseiycqlm kqtscrppqk yslmqcwqll alcaplflpq hhflwyvkqq lqrhadprse
      541 tgqyatycqr avertlrtge rearpsrmev vsillrnpfh hslpfsipvh ftngtyhvvg
      601 fdgsstvdef lqrlnqeigm rkpshsgfal ftddpsgrdl ehclqgsvki cdaiskweqa
      661 mkelhpgkse ggtrvvklmy knrlyfrsqv kgetdrerll lasqtsreiv agrfpinkel
      721 alemaalmaq veygdlekpa lpgpggtspa kaqhllqqvl drfhprryrh gapaeqlrhl
      781 admlttkwat lqgcsppeci riyltvarkw pffgaklfaa qpaqlssken alvwiavned
      841 gvsildhntm qvhitypyss vttfggcrdd fmlvirsipd kssgkshiek lifrmaapki
      901 aeatfimasy mnhctttvnp ptnppgacql weldgrqffs svscatkgpt ll
//
LOCUS       XP_047287577             924 aa            linear   PRI 05-AUG-2025
DEFINITION  pleckstrin homology domain-containing family H member 1 isoform X8
            [Homo sapiens].
ACCESSION   XP_047287577
VERSION     XP_047287577.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431621.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..924
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..924
                     /product="pleckstrin homology domain-containing family H
                     member 1 isoform X8"
                     /calculated_mol_wt=102958
     Region          141..236
                     /region_name="PH1_PLEKHH1_PLEKHH2"
                     /note="Pleckstrin homology (PH) domain containing, family
                     H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain,
                     repeat 1; cd13282"
                     /db_xref="CDD:241436"
     Region          248..351
                     /region_name="PH"
                     /note="Pleckstrin homology domain; smart00233"
                     /db_xref="CDD:214574"
     Region          392..546
                     /region_name="MyTH4"
                     /note="Domain in Myosin and Kinesin Tails; smart00139"
                     /db_xref="CDD:214535"
     Region          556..662
                     /region_name="Ubl1_cv_Nsp3_N-like"
                     /note="first ubiquitin-like (Ubl) domain located at the
                     N-terminus of coronavirus SARS-CoV non-structural protein
                     3 (Nsp3) and related proteins; cl28922"
                     /db_xref="CDD:475130"
     Region          559..790
                     /region_name="B41"
                     /note="Band 4.1 homologues; smart00295"
                     /db_xref="CDD:214604"
     Region          786..888
                     /region_name="FERM_C-lobe_PLEKHH1_PLEKHH2"
                     /note="FERM domain C-lobe of Pleckstrin homology
                     domain-containing family H; cd13206"
                     /db_xref="CDD:241360"
     Site            order(794,816,818,826)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:241360"
     Site            order(830,835..838,876,880,883..884,887)
                     /site_type="other"
                     /note="TSLC1 peptide binding site [polypeptide binding]"
                     /db_xref="CDD:241360"
     Site            876..887
                     /site_type="other"
                     /note="putative actin binding site 2 [polypeptide
                     binding]"
                     /db_xref="CDD:241360"
     CDS             1..924
                     /gene="PLEKHH1"
                     /coded_by="XM_047431621.1:5469..8243"
                     /db_xref="GeneID:57475"
                     /db_xref="HGNC:HGNC:17733"
ORIGIN      
        1 meekmvkass ppalvspgsf sglvyknvtv pvytalkgra tqisnmpfmd essgsdddcs
       61 sqasfrisvp ssesrktsgl gspraikrgv smsslssegd yaippdacsl dsdysepehk
      121 lqrtssystd glglggesle ksgyllkmgs qvktwkrrwf vlrqgqimyy kspsdvirkp
      181 qgqvdlnsrc qivrgegsqt fqlisekkty yltadspsll eewirvlqsl lkvqatgppa
      241 llrggtkptv kgwltkvkhg hskvvwcalv gkifyyyrsh edkrplgclp vrdahieevd
      301 rscdsdedye aggtrrllss hctlvihpte hsptylligt khekdtwlyh ltvaaggssa
      361 kvgtayeqli gklmdgegdp dsplwrhpml cyskdglyas lttlpsealq tealklfksc
      421 qlfinvpvea asvdyhvsla qtalqvclvh pelqseiycq lmkqtscrpp qkyslmqcwq
      481 llalcaplfl pqhhflwyvk qqlqrhadpr setgqyatyc qravertlrt gerearpsrm
      541 evvsillrnp fhhslpfsip vhftngtyhv vgfdgsstvd eflqrlnqei gmrkpshsgf
      601 alftddpsgr dlehclqgsv kicdaiskwe qamkelhpgk seggtrvvkl myknrlyfrs
      661 qvkgetdrer lllasqtsre ivagrfpink elalemaalm aqveygdlek palpgpggts
      721 pakaqhllqq vldrfhprry rhgapaeqlr hladmlttkw atlqgcsppe ciriyltvar
      781 kwpffgaklf aaqpaqlssk enalvwiavn edgvsildhn tmqvhitypy ssvttfggcr
      841 ddfmlvirsi pdkssgkshi eklifrmaap kiaeatfima symnhctttv npptnppgac
      901 qlweldgrqf fssvscatkg ptll
//
LOCUS       XP_011535317             919 aa            linear   PRI 05-AUG-2025
DEFINITION  pleckstrin homology domain-containing family H member 1 isoform X9
            [Homo sapiens].
ACCESSION   XP_011535317
VERSION     XP_011535317.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537015.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..919
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..919
                     /product="pleckstrin homology domain-containing family H
                     member 1 isoform X9"
                     /calculated_mol_wt=102856
     Region          108..203
                     /region_name="PH1_PLEKHH1_PLEKHH2"
                     /note="Pleckstrin homology (PH) domain containing, family
                     H (with MyTH4 domain) members 1 and 2 (PLEKHH1) PH domain,
                     repeat 1; cd13282"
                     /db_xref="CDD:241436"
     Region          387..541
                     /region_name="MyTH4"
                     /note="Domain in Myosin and Kinesin Tails; smart00139"
                     /db_xref="CDD:214535"
     Region          551..657
                     /region_name="Ubl1_cv_Nsp3_N-like"
                     /note="first ubiquitin-like (Ubl) domain located at the
                     N-terminus of coronavirus SARS-CoV non-structural protein
                     3 (Nsp3) and related proteins; cl28922"
                     /db_xref="CDD:475130"
     Region          554..785
                     /region_name="B41"
                     /note="Band 4.1 homologues; smart00295"
                     /db_xref="CDD:214604"
     Region          781..883
                     /region_name="FERM_C-lobe_PLEKHH1_PLEKHH2"
                     /note="FERM domain C-lobe of Pleckstrin homology
                     domain-containing family H; cd13206"
                     /db_xref="CDD:241360"
     Site            order(789,811,813,821)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:241360"
     Site            order(825,830..833,871,875,878..879,882)
                     /site_type="other"
                     /note="TSLC1 peptide binding site [polypeptide binding]"
                     /db_xref="CDD:241360"
     Site            871..882
                     /site_type="other"
                     /note="putative actin binding site 2 [polypeptide
                     binding]"
                     /db_xref="CDD:241360"
     CDS             1..919
                     /gene="PLEKHH1"
                     /coded_by="XM_011537015.3:2445..5204"
                     /db_xref="GeneID:57475"
                     /db_xref="HGNC:HGNC:17733"
ORIGIN      
        1 mnvdkratqi snmpfmdess gsdddcssqa sfrisvpsse srktsglgsp raikrgvsms
       61 slssegdyai ppdacsldsd ysepehklqr tssystdglg lggesleksg yllkmgsqvk
      121 twkrrwfvlr qgqimyyksp sdvirkpqgq vdlnsrcqiv rgegsqtfql isekktyylt
      181 adspslleew irvlqsllkv qatgppallr ggtkptvkgw ltkvkhghsk vvwcalvgki
      241 fyyyrshedk lhgayvfrer rlphpplalp fmedccpqrp lgclpvrdah ieevdrscds
      301 dedyeaggtr rllsshctlv ihptehspty lligtkhekd twlyhltvaa ggssakvgta
      361 yeqligklmd gegdpdsplw rhpmlcyskd glyaslttlp sealqtealk lfkscqlfin
      421 vpveaasvdy hvslaqtalq vclvhpelqs eiycqlmkqt scrppqkysl mqcwqllalc
      481 aplflpqhhf lwyvkqqlqr hadprsetgq yatycqrave rtlrtgerea rpsrmevvsi
      541 llrnpfhhsl pfsipvhftn gtyhvvgfdg sstvdeflqr lnqeigmrkp shsgfalftd
      601 dpsgrdlehc lqgsvkicda iskweqamke lhpgkseggt rvvklmyknr lyfrsqvkge
      661 tdrerlllas qtsreivagr fpinkelale maalmaqvey gdlekpalpg pggtspakaq
      721 hllqqvldrf hprryrhgap aeqlrhladm lttkwatlqg csppeciriy ltvarkwpff
      781 gaklfaaqpa qlsskenalv wiavnedgvs ildhntmqvh itypyssvtt fggcrddfml
      841 virsipdkss gkshieklif rmaapkiaea tfimasymnh ctttvnpptn ppgacqlwel
      901 dgrqffssvs catkgptll
//
LOCUS       XP_011535318            1018 aa            linear   PRI 05-AUG-2025
DEFINITION  protein NYNRIN isoform X1 [Homo sapiens].
ACCESSION   XP_011535318
VERSION     XP_011535318.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537016.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1018
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1018
                     /product="protein NYNRIN isoform X1"
                     /calculated_mol_wt=113254
     Region          <2..62
                     /region_name="RNase_Zc3h12a"
                     /note="Zc3h12a-like Ribonuclease NYN domain; pfam11977"
                     /db_xref="CDD:403256"
     Region          250..350
                     /region_name="RT_RNaseH_2"
                     /note="RNase H-like domain found in reverse transcriptase;
                     pfam17919"
                     /db_xref="CDD:465567"
     Region          656..709
                     /region_name="Integrase_H2C2"
                     /note="Integrase zinc binding domain; pfam17921"
                     /db_xref="CDD:465569"
     CDS             1..1018
                     /gene="NYNRIN"
                     /gene_synonym="CGIN1; KIAA1305"
                     /coded_by="XM_011537016.2:1234..4290"
                     /db_xref="GeneID:57523"
                     /db_xref="HGNC:HGNC:20165"
                     /db_xref="MIM:620129"
ORIGIN      
        1 mfmvklaeet dgiivtneqi hilmnsskkl mvkdrllpft fagnlfmvpd dplgrdgptl
       61 deflkkpnrl dtdignflkv wktlppssas vtelsddads gpleslpnme evreekeerq
      121 deeqrqgqgt qkaaeeddld sslasvfrve cpslseeilr clslhdppdg aldidllpga
      181 aspylgipwd gkapcqqvla hlaqltipsn ftalsffmgf mdshrdaipd yealvgplhs
      241 llkqkpdwqw dqeheeafla lkralvsalc lmapnsqlpf rlevtvshva ltailhqehs
      301 grkhpiayts kpllpdeesq gpqsggdspy avawalkhfs rcigdtpvvl dlsyasrtta
      361 dpevregrrv skawlirwsl lvqdkgkral elallqgllg enrlltpaas mprffqvlpp
      421 fsdlstfvci hmsgycfyre dewcagfgly vlsptsppvs lsfscspytp tyahlaavac
      481 glerfgqspl pvvflthcnw ifsllwellp lwrargflss dgaplphpsl lsyiisltsg
      541 lsslpfiyrt syrgslfavt vdtlakqgaq gggqwwslpk dvpaptvsph amgkrpnlla
      601 lqlsdstlad iiarlqagqk lsgsspfssa fnslsldkes gllmfkgdkk prvwvvptql
      661 rrdlifsvhd iplgahqrpe etykklrllg wwpgmqehvk dycrsclfci prnligselk
      721 viespwplrs tapwsnlqie vvgpvtisee ghkhvlivad pntrwveafp lkpythtava
      781 qvllqhvfar wgvpvrleaa qgpqfarhvl vscglalgaq vaslsrdlqf pcltssgayw
      841 efkralkefi flhgkkwaas lpllhlafra sstdatpfkv ltggesrlte plwwemssan
      901 ieglkmdvfl lqlvgellel hwrvadkase kaenrrfkre sqekewnvgd qvlllslprn
      961 gssakwvgpf yigdrlslsl yriwgfptpe klgciypssl mkafaksgtp lsfkvleq
//
LOCUS       XP_016876994             465 aa            linear   PRI 05-AUG-2025
DEFINITION  thioredoxin domain-containing protein 16 isoform X1 [Homo sapiens].
ACCESSION   XP_016876994
VERSION     XP_016876994.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021505.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..465
                     /product="thioredoxin domain-containing protein 16 isoform
                     X1"
                     /calculated_mol_wt=52616
     Region          394..>437
                     /region_name="Protein Disulfide Oxidoreductases and Other
                     Proteins with a Thioredoxin fold"
                     /note="The thioredoxin (TRX)-like superfamily is a large,
                     diverse group of proteins containing a TRX fold. Many
                     members contain a classic TRX domain with a redox active
                     CXXC motif. They function as protein disulfide
                     oxidoreductases (PDOs), altering the redox...; cl00388"
                     /db_xref="CDD:469754"
     CDS             1..465
                     /gene="TXNDC16"
                     /gene_synonym="ERp90; KIAA1344"
                     /coded_by="XM_017021505.2:372..1769"
                     /db_xref="GeneID:57544"
                     /db_xref="HGNC:HGNC:19965"
                     /db_xref="MIM:616179"
ORIGIN      
        1 mfsgfnvfrv gisfvimcif ymptvnslpe lspqkyfstl qpgkaslayf cqadsprtsv
       61 fleelneavr plqdygisva kvncvkeeis rycgkekdlm kaylfkgnil lrefptdtlf
      121 dvnaivahvl fallfsevky itnledlqni enalkgkani ifsyvraigi pehravmeaa
      181 fvygttyqfv ltteialles igsedveyah lyffhcklvl dltqqcrrtl meqplttlni
      241 hlfiktmkap lltevaedpq qvstvhlqlg lplvfivsqq atyeadrrta ewvawrllgk
      301 agvllllrds levnipqdan vvfkraeegv pveflvlhdv dliishvenn mhieeiqede
      361 dndmegpdid vqddevaetv frdrkrklpl eltvelteet fnatvmasds ivlfyagwqa
      421 vsmaflqsyi dvavklkvvw ghlvcslqht wlaekgrqsg hlgnv
//
LOCUS       XP_011535320            2752 aa            linear   PRI 05-AUG-2025
DEFINITION  protein unc-79 homolog isoform X1 [Homo sapiens].
ACCESSION   XP_011535320
VERSION     XP_011535320.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537018.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2752
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2752
                     /product="protein unc-79 homolog isoform X1"
                     /calculated_mol_wt=308306
     Region          159..690
                     /region_name="UNC-79"
                     /note="Cation-channel complex subunit UNC-79; pfam14776"
                     /db_xref="CDD:434201"
     CDS             1..2752
                     /gene="UNC79"
                     /gene_synonym="KIAA1409"
                     /coded_by="XM_011537018.3:3540..11798"
                     /db_xref="GeneID:57578"
                     /db_xref="HGNC:HGNC:19966"
                     /db_xref="MIM:616884"
ORIGIN      
        1 mdsvensvee etretliima pwdlqrgmtr tgsfttarsk vrsgmwtmlv tpvaskiryl
       61 qeyhnrvlhn iypvpsgtdi antlkyfsqt llsilsrtgk kenqdasnlt vpmtmclfpv
      121 pfpltpslrp qvssinptvt rsllysvlrd apsergpqsr daqlsdypsl dyqglyvtlv
      181 tlldlvpllq hgqhdlgqsi fytttcllpf lnddilstlp ytmistlatf ppflhkdiie
      241 ylstsflpma ilgssrregv pahvnlsass mlmiamqyts npvyhcqlle clmkykqevw
      301 kdllyviayg psqvkppavq mlfhywpnlk ppgaiseyrg lqytawnpih cqhiechnai
      361 nkpavkmcid pslsvalgdk ppplylceec seriagdhse wlidvllpqa eisaicqkkn
      421 csshvrravv tcfsagccgr hgnrpvryck rchsnhhsne vgaaaethly qtspppintr
      481 ecgaeelvca veavisllke aefhaeqreh elnrrrqlgl ssshhsldna dfdnkdddkh
      541 dqrllsqfgi wflvslctps entpteslar lvamvfqwfh staymmddev gslveklkpq
      601 fvtkwlktvc dvrfdvmvmc llpkpmefar vggywdkscs tvtqlkegln rilclipynv
      661 inqsvwecim pewleairte vpdnqlkefr evlskmfdie lcplpfsmee mfgfiscrft
      721 gypssvqeqa llwlhvlsel dimvplqlli smfsdgvnsv kelanqrksr vselagnlas
      781 rrvsvasdpg rrvqhnmlsp fhspfqspfr splrspfrsp fknfghpggr tidfdcedde
      841 mnlncfilmf dlllkqmelq ddgitmgleh slskdiisii nnvfqapwgg shtcqkdeka
      901 iecnlcqssi lcyqlacell erlapkeesr lveptdsled sllssrpefi igpegeeeen
      961 paskhgenpg nctepvehaa vkndterkfc yqqlpvtlrl iytifqemak feepdilfnm
     1021 lnclkilclh geclyiarkd hpqflayiqd hmliaslwrv vksefsqlss lavplllhal
     1081 slphgadifw tiingnfnsk dwkmrfeave kvavicrfld ihsvtknhll kyslahafcc
     1141 fltavedvnp avatraglll dtikrpalqg lclcldfqfd tvvkdrptil skllllhflk
     1201 qdipalswef fvnrfetlsl eaqlhldcnk efpfpttita vrtnvanlsd aalwkikrar
     1261 farnrqksvr slrdsvkgpv eskralslpe tltskipmrl trheqsapal ggtpeqtpgq
     1321 qspendntik dllpedagid hqtvhqlitv lmkfmakdes saesdissak afntvkrhly
     1381 vllgydqqeg cfmiapqkmr lstcfnafia giaqvmdyni nlgkhllplv vqvlkycscp
     1441 qlrhyfqqpp rcslwslkph irqmwlkall vilykypyrd cdiskillhl ihitvntlna
     1501 qyhsckphat agplysdnsn isrysekeke edsvfdesdi hdtptgpcnk esqtffarlk
     1561 riggskmvky qpvemnvqrs eielaeyret galqdsllhc vreesipkkk lrsfkqksld
     1621 ignadsllft ldehrrksci drcdiekppt qaayiaqrpn dpgrsrqnsa trpdnseipe
     1681 npamegfpda rrpvipevrl ncmetfevkv dspvkpapke dldlidlssd stsgpekhsi
     1741 lstsdsdslv feplpplriv esdeeeetmn qgddgpsgkn aasspsvpsh psvlslstap
     1801 lvqvsvedcs kdfsskdsgn nqsagntdsa litledpmda egsskpeelp efscgspltl
     1861 kqkrdllqks falpemsldd hpdpgtegek pgelmpssga ktvllkvped aenptesekp
     1921 dtsaesdteq nperkveedg aeesefkiqi vprqrkqrki avsaiqreyl disfnildkl
     1981 geqkdpdpst kglstlempr esssaptlda gvpetsshss istqyrqmkr gslgvltmsq
     2041 lmkrqlehqs saphnisnwd teqiqpgkrq cnvptclnpd legqplrmrg atkssllsap
     2101 sivsmfvpap eeftdeqptv mtdkchdcga ileeydeetl glaivvlstf ihlspdlaap
     2161 llldimqsvg rlassttfsn qaesmmvpgn aagvakqflr cifhqlapng ifpqlfqsti
     2221 kdgtflrtla sslmdfnels siaalsqlle glnnkknlpa ggamirclen iatfmealpm
     2281 dspsslwtti snqfqtffak lpcvlplkcs ldsslrimic llkipstnat rsllepfskl
     2341 lsfviqnavf tlaylvelcg lcyraftker dkfylsrsvv lellqalklk splpdtnlll
     2401 lvqficadag tklaestils kqmiasvpgc gtaamecvrq yinevldfma dmhtltklks
     2461 hmktcsqplh edtfgghlkv glaqiaamdi srgnhrdnka virylpwlyh ppsamqqgpk
     2521 efiecvshir llswlllgsl thnavcpnas spclpiplda gshvadhliv iligfpeqsk
     2581 tsvlhmcslf hafifaqlwt vyceqsavat nlqnqnefsf tailtalefw srvtpsilql
     2641 mahnkvmvem vclhvislme alqecnstif vklipmwlpm iqsnikhlsa glqlrlqaiq
     2701 nhvnhhslrt lpgsgqssag laalrkwlqc tqfkmaqvei qsseaasqfy pl
//
LOCUS       XP_011535322            2730 aa            linear   PRI 05-AUG-2025
DEFINITION  protein unc-79 homolog isoform X2 [Homo sapiens].
ACCESSION   XP_011535322
VERSION     XP_011535322.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537020.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2730
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2730
                     /product="protein unc-79 homolog isoform X2"
                     /calculated_mol_wt=306048
     Region          159..690
                     /region_name="UNC-79"
                     /note="Cation-channel complex subunit UNC-79; pfam14776"
                     /db_xref="CDD:434201"
     CDS             1..2730
                     /gene="UNC79"
                     /gene_synonym="KIAA1409"
                     /coded_by="XM_011537020.3:3540..11732"
                     /db_xref="GeneID:57578"
                     /db_xref="HGNC:HGNC:19966"
                     /db_xref="MIM:616884"
ORIGIN      
        1 mdsvensvee etretliima pwdlqrgmtr tgsfttarsk vrsgmwtmlv tpvaskiryl
       61 qeyhnrvlhn iypvpsgtdi antlkyfsqt llsilsrtgk kenqdasnlt vpmtmclfpv
      121 pfpltpslrp qvssinptvt rsllysvlrd apsergpqsr daqlsdypsl dyqglyvtlv
      181 tlldlvpllq hgqhdlgqsi fytttcllpf lnddilstlp ytmistlatf ppflhkdiie
      241 ylstsflpma ilgssrregv pahvnlsass mlmiamqyts npvyhcqlle clmkykqevw
      301 kdllyviayg psqvkppavq mlfhywpnlk ppgaiseyrg lqytawnpih cqhiechnai
      361 nkpavkmcid pslsvalgdk ppplylceec seriagdhse wlidvllpqa eisaicqkkn
      421 csshvrravv tcfsagccgr hgnrpvryck rchsnhhsne vgaaaethly qtspppintr
      481 ecgaeelvca veavisllke aefhaeqreh elnrrrqlgl ssshhsldna dfdnkdddkh
      541 dqrllsqfgi wflvslctps entpteslar lvamvfqwfh staymmddev gslveklkpq
      601 fvtkwlktvc dvrfdvmvmc llpkpmefar vggywdkscs tvtqlkegln rilclipynv
      661 inqsvwecim pewleairte vpdnqlkefr evlskmfdie lcplpfsmee mfgfiscrft
      721 gypssvqeqa llwlhvlsel dimvplqlli smfsdgvnsv kelanqrksr vselagnlas
      781 rrvsvasdpg rrvqhnmlsp fhspfqspfr splrspfrsp fknfghpggr tidfdcedde
      841 mnlncfilmf dlllkqmelq ddgitmgleh slskdiisii nnvfqapwgg shtcqkdeka
      901 iecnlcqssi lcyqlacell erlapkeesr lveptdsled sllssrpefi igpegeeeen
      961 paskhgenpg nctepvehaa vkndterkfc yqqlpvtlrl iytifqemak feepdilfnm
     1021 lnclkilclh geclyiarkd hpqflayiqd hmliaslwrv vksefsqlss lavplllhal
     1081 slphgadifw tiingnfnsk dwkmrfeave kvavicrfld ihsvtknhll kyslahafcc
     1141 fltavedvnp avatraglll dtikrpalqg lclcldfqfd tvvkdrptil skllllhflk
     1201 qdipalswef fvnrfetlsl eaqlhldcnk efpfpttita vrtnvanlsd aalwkikrar
     1261 farnrqksvr slrdsvkgpv eskralslpe tltskirqqs pendntikdl lpedagidhq
     1321 tvhqlitvlm kfmakdessa esdissakaf ntvkrhlyvl lgydqqegcf miapqkmrls
     1381 tcfnafiagi aqvmdyninl gkhllplvvq vlkycscpql rhyfqqpprc slwslkphir
     1441 qmwlkallvi lykypyrdcd iskillhlih itvntlnaqy hsckphatag plysdnsnis
     1501 rysekekeed svfdesdihd tptgpcnkes qtffarlkri ggskmvkyqp vemnvqrsei
     1561 elaeyretga lqdsllhcvr eesipkkklr sfkqksldig nadsllftld ehrrkscidr
     1621 cdiekpptqa ayiaqrpndp grsrqnsatr pdnseipenp amegfpdarr pvipevrlnc
     1681 metfevkvds pvkpapkedl dlidlssdst sgpekhsils tsdsdslvfe plpplrives
     1741 deeeetmnqg ddgpsgknaa sspsvpshps vlslstaplv qvsvedcskd fsskdsgnnq
     1801 sagntdsali tledpmdaeg sskpeelpef scgspltlkq krdllqksfa lpemslddhp
     1861 dpgtegekpg elmpssgakt vllkvpedae nptesekpdt saesdteqnp erkveedgae
     1921 esefkiqivp rqrkqrkiav saiqreyldi sfnildklge qkdpdpstkg lstlempres
     1981 ssaptldagv petsshssis tqyrqmkrgs lgvltmsqlm krqlehqssa phnisnwdte
     2041 qiqpgkrqcn vptclnpdle gqplrmrgat kssllsapsi vsmfvpapee ftdeqptvmt
     2101 dkchdcgail eeydeetlgl aivvlstfih lspdlaapll ldimqsvgrl assttfsnqa
     2161 esmmvpgnaa gvakqflrci fhqlapngif pqlfqstikd gtflrtlass lmdfnelssi
     2221 aalsqllegl nnkknlpagg amirclenia tfmealpmds psslwttisn qfqtffaklp
     2281 cvlplkcsld sslrimicll kipstnatrs llepfsklls fviqnavftl aylvelcglc
     2341 yraftkerdk fylsrsvvle llqalklksp lpdtnllllv qficadagtk laestilskq
     2401 miasvpgcgt aamecvrqyi nevldfmadm htltklkshm ktcsqplhed tfgghlkvgl
     2461 aqiaamdisr gnhrdnkavi rylpwlyhpp samqqgpkef iecvshirll swlllgslth
     2521 navcpnassp clpipldags hvadhlivil igfpeqskts vlhmcslfha fifaqlwtvy
     2581 ceqsavatnl qnqnefsfta iltalefwsr vtpsilqlma hnkvmvemvc lhvislmeal
     2641 qecnstifvk lipmwlpmiq snikhlsagl qlrlqaiqnh vnhhslrtlp gsgqssagla
     2701 alrkwlqctq fkmaqveiqs seaasqfypl
//
LOCUS       XP_016876995            2718 aa            linear   PRI 05-AUG-2025
DEFINITION  protein unc-79 homolog isoform X3 [Homo sapiens].
ACCESSION   XP_016876995
VERSION     XP_016876995.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021506.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2718
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2718
                     /product="protein unc-79 homolog isoform X3"
                     /calculated_mol_wt=304262
     Region          159..690
                     /region_name="UNC-79"
                     /note="Cation-channel complex subunit UNC-79; pfam14776"
                     /db_xref="CDD:434201"
     CDS             1..2718
                     /gene="UNC79"
                     /gene_synonym="KIAA1409"
                     /coded_by="XM_017021506.2:3540..11696"
                     /db_xref="GeneID:57578"
                     /db_xref="HGNC:HGNC:19966"
                     /db_xref="MIM:616884"
ORIGIN      
        1 mdsvensvee etretliima pwdlqrgmtr tgsfttarsk vrsgmwtmlv tpvaskiryl
       61 qeyhnrvlhn iypvpsgtdi antlkyfsqt llsilsrtgk kenqdasnlt vpmtmclfpv
      121 pfpltpslrp qvssinptvt rsllysvlrd apsergpqsr daqlsdypsl dyqglyvtlv
      181 tlldlvpllq hgqhdlgqsi fytttcllpf lnddilstlp ytmistlatf ppflhkdiie
      241 ylstsflpma ilgssrregv pahvnlsass mlmiamqyts npvyhcqlle clmkykqevw
      301 kdllyviayg psqvkppavq mlfhywpnlk ppgaiseyrg lqytawnpih cqhiechnai
      361 nkpavkmcid pslsvalgdk ppplylceec seriagdhse wlidvllpqa eisaicqkkn
      421 csshvrravv tcfsagccgr hgnrpvryck rchsnhhsne vgaaaethly qtspppintr
      481 ecgaeelvca veavisllke aefhaeqreh elnrrrqlgl ssshhsldna dfdnkdddkh
      541 dqrllsqfgi wflvslctps entpteslar lvamvfqwfh staymmddev gslveklkpq
      601 fvtkwlktvc dvrfdvmvmc llpkpmefar vggywdkscs tvtqlkegln rilclipynv
      661 inqsvwecim pewleairte vpdnqlkefr evlskmfdie lcplpfsmee mfgfiscrft
      721 gypssvqeqa llwlhvlsel dimvplqlli smfsdgvnsv kelanqrksr vselagnlas
      781 rrvsvasdpg rrvqhnmlsp fhspfqspfr splrspfrsp fknfghpggr tidfdcedde
      841 mnlncfilmf dlllkqmelq ddgitmgleh slskdiisii nnvfqapwgg shtcqkdeka
      901 iecnlcqssi lcyqlacell erlapkeesr lveptdsled sllssrpefi igpegeeeen
      961 paskhgenpg nctepvehaa vkndterkfc yqqlpvtlrl iytifqemak feepdilfnm
     1021 lnclkilclh geclyiarkd hpqflayiqd hmliaslwrv vksefsqlss lavplllhal
     1081 slphgadifw tiingnfnsk dwkmrfeave kvavicrfld ihsvtknhll kyslahafcc
     1141 fltavedvnp avatraglll dtikrpalqg lclcldfqfd tvvkdrptil skllllhflk
     1201 qdipalswef fvnrfetlsl eaqlhldcnk efpfpttita vrtnvanlsd aalwkikrar
     1261 farnrqksvr slrdsvkgpv eskralslpe tltskipmrl trheqsapal ggtpeqtpgq
     1321 qspendntik dllpedagid hqtvhqlitv lmkfmakdes saesdissak afntvkrhly
     1381 vllgydqqeg cfmiapqkmr lstcfnafia giaqpprcsl wslkphirqm wlkallvily
     1441 kypyrdcdis killhlihit vntlnaqyhs ckphatagpl ysdnsnisry sekekeedsv
     1501 fdesdihdtp tgpcnkesqt ffarlkrigg skmvkyqpve mnvqrseiel aeyretgalq
     1561 dsllhcvree sipkkklrsf kqksldigna dsllftldeh rrkscidrcd iekpptqaay
     1621 iaqrpndpgr srqnsatrpd nseipenpam egfpdarrpv ipevrlncme tfevkvdspv
     1681 kpapkedldl idlssdstsg pekhsilsts dsdslvfepl pplrivesde eeetmnqgdd
     1741 gpsgknaass psvpshpsvl slstaplvqv svedcskdfs skdsgnnqsa gntdsalitl
     1801 edpmdaegss kpeelpefsc gspltlkqkr dllqksfalp emslddhpdp gtegekpgel
     1861 mpssgaktvl lkvpedaenp tesekpdtsa esdteqnper kveedgaees efkiqivprq
     1921 rkqrkiavsa iqreyldisf nildklgeqk dpdpstkgls tlempresss aptldagvpe
     1981 tsshssistq yrqmkrgslg vltmsqlmkr qlehqssaph nisnwdteqi qpgkrqcnvp
     2041 tclnpdlegq plrmrgatks sllsapsivs mfvpapeeft deqptvmtdk chdcgailee
     2101 ydeetlglai vvlstfihls pdlaapllld imqsvgrlas sttfsnqaes mmvpgnaagv
     2161 akqflrcifh qlapngifpq lfqstikdgt flrtlasslm dfnelssiaa lsqlleglnn
     2221 kknlpaggam ircleniatf mealpmdsps slwttisnqf qtffaklpcv lplkcsldss
     2281 lrimicllki pstnatrsll epfskllsfv iqnavftlay lvelcglcyr aftkerdkfy
     2341 lsrsvvlell qalklksplp dtnllllvqf icadagtkla estilskqmi asvpgcgtaa
     2401 mecvrqyine vldfmadmht ltklkshmkt csqplhedtf gghlkvglaq iaamdisrgn
     2461 hrdnkaviry lpwlyhppsa mqqgpkefie cvshirllsw lllgslthna vcpnasspcl
     2521 pipldagshv adhlivilig fpeqsktsvl hmcslfhafi faqlwtvyce qsavatnlqn
     2581 qnefsftail talefwsrvt psilqlmahn kvmvemvclh vislmealqe cnstifvkli
     2641 pmwlpmiqsn ikhlsaglql rlqaiqnhvn hhslrtlpgs gqssaglaal rkwlqctqfk
     2701 maqveiqsse aasqfypl
//
LOCUS       XP_016876996            2713 aa            linear   PRI 05-AUG-2025
DEFINITION  protein unc-79 homolog isoform X4 [Homo sapiens].
ACCESSION   XP_016876996
VERSION     XP_016876996.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021507.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2713
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2713
                     /product="protein unc-79 homolog isoform X4"
                     /calculated_mol_wt=303764
     Region          159..690
                     /region_name="UNC-79"
                     /note="Cation-channel complex subunit UNC-79; pfam14776"
                     /db_xref="CDD:434201"
     CDS             1..2713
                     /gene="UNC79"
                     /gene_synonym="KIAA1409"
                     /coded_by="XM_017021507.2:3540..11681"
                     /db_xref="GeneID:57578"
                     /db_xref="HGNC:HGNC:19966"
                     /db_xref="MIM:616884"
ORIGIN      
        1 mdsvensvee etretliima pwdlqrgmtr tgsfttarsk vrsgmwtmlv tpvaskiryl
       61 qeyhnrvlhn iypvpsgtdi antlkyfsqt llsilsrtgk kenqdasnlt vpmtmclfpv
      121 pfpltpslrp qvssinptvt rsllysvlrd apsergpqsr daqlsdypsl dyqglyvtlv
      181 tlldlvpllq hgqhdlgqsi fytttcllpf lnddilstlp ytmistlatf ppflhkdiie
      241 ylstsflpma ilgssrregv pahvnlsass mlmiamqyts npvyhcqlle clmkykqevw
      301 kdllyviayg psqvkppavq mlfhywpnlk ppgaiseyrg lqytawnpih cqhiechnai
      361 nkpavkmcid pslsvalgdk ppplylceec seriagdhse wlidvllpqa eisaicqkkn
      421 csshvrravv tcfsagccgr hgnrpvryck rchsnhhsne vgaaaethly qtspppintr
      481 ecgaeelvca veavisllke aefhaeqreh elnrrrqlgl ssshhsldna dfdnkdddkh
      541 dqrllsqfgi wflvslctps entpteslar lvamvfqwfh staymmddev gslveklkpq
      601 fvtkwlktvc dvrfdvmvmc llpkpmefar vggywdkscs tvtqlkegln rilclipynv
      661 inqsvwecim pewleairte vpdnqlkefr evlskmfdie lcplpfsmee mfgfiscrft
      721 gypssvqeqa llwlhvlsel dimvplqlli smfsdgvnsv kelanqrksr vselagnlas
      781 rrvsvasdpg rrvqhnmlsp fhspfqspfr splrspfrsp fknfghpggr tidfdcedde
      841 mnlncfilmf dlllkqmelq ddgitmgleh slskdiisii nnvfqapwgg shtcqkdeka
      901 iecnlcqssi lcyqlacell erlapkeesr lveptdsled sllssrpefi igpegeeeen
      961 paskhgenpg nctepvehaa vkndterkfc yqqlpvtlrl iytifqemak feepdilfnm
     1021 lnclkilclh geclyiarkd hpqflayiqd hmliaslwrv vksefsqlss lavplllhal
     1081 slphgadifw tiingnfnsk dwkmrfeave kvavicrfld ihsvtknhll kyslahafcc
     1141 fltavedvnp avatraglll dtikrpalqg lclcldfqfd tvvkdrptil skllllhflk
     1201 qdipalswef fvnrfetlsl eaqlhldcnk efpfpttita vrtnvanlsd aalwkikrar
     1261 farnrqksvr slrdsvkgpv eskralslpe tltskipmrl trheqsapal ggtpeqtpgq
     1321 qspendntik dllpedagid hqtvhqlitv lmkfmakdes saesdissak afntvkrhly
     1381 vllgydqqeg cfmiapqkmr lstcfnafia giaqvmdyni nlgkhllplv vqvlkycscp
     1441 qlrhyfqqpp rcslwslkph irqmwlkall vilykypyrd cdiskillhl ihitvntlna
     1501 qyhsckphat agplysdnsn isrysekeke edsvfdesdi hdtptgpcnk esqtffarlk
     1561 riggskmvky qpvemnvqrs eielaeyret galqdsllhc vreesipkkk lrsfkqksld
     1621 ignadsllft ldehrrksci drcdiekppt qaayiaqrpn dpgrsrqnsa trpdnseipe
     1681 npamegfpda rrpvipevrl ncmetfevkv dspvkpapke dldlidlssd stsgpekhsi
     1741 lstsdsdslv feplpplriv esdeeeetmn qgddgpsgkn aasspsvpsh psvlslstap
     1801 lvqvsvedcs kdfsskdsgn nqsagntdsa litledpmda egsskpeelp efscgspltl
     1861 kqkrdllqks falpemsldd hpdpgtegek pgelmpssga ktvllkvped aenptesekp
     1921 dtsaesdteq nperkveedg aeesefkiqi vprqrkqrki avsaiqreyl disfnildkl
     1981 geqkdpdpst kglstlempr esssaptlda gvpetsshss iskqiqpgkr qcnvptclnp
     2041 dlegqplrmr gatkssllsa psivsmfvpa peeftdeqpt vmtdkchdcg aileeydeet
     2101 lglaivvlst fihlspdlaa pllldimqsv grlassttfs nqaesmmvpg naagvakqfl
     2161 rcifhqlapn gifpqlfqst ikdgtflrtl asslmdfnel ssiaalsqll eglnnkknlp
     2221 aggamircle niatfmealp mdspsslwtt isnqfqtffa klpcvlplkc sldsslrimi
     2281 cllkipstna trsllepfsk llsfviqnav ftlaylvelc glcyraftke rdkfylsrsv
     2341 vlellqalkl ksplpdtnll llvqficada gtklaestil skqmiasvpg cgtaamecvr
     2401 qyinevldfm admhtltklk shmktcsqpl hedtfgghlk vglaqiaamd isrgnhrdnk
     2461 avirylpwly hppsamqqgp kefiecvshi rllswlllgs lthnavcpna sspclpipld
     2521 agshvadhli viligfpeqs ktsvlhmcsl fhafifaqlw tvyceqsava tnlqnqnefs
     2581 ftailtalef wsrvtpsilq lmahnkvmve mvclhvislm ealqecnsti fvklipmwlp
     2641 miqsnikhls aglqlrlqai qnhvnhhslr tlpgsgqssa glaalrkwlq ctqfkmaqve
     2701 iqsseaasqf ypl
//
LOCUS       XP_016876997            2702 aa            linear   PRI 05-AUG-2025
DEFINITION  protein unc-79 homolog isoform X5 [Homo sapiens].
ACCESSION   XP_016876997
VERSION     XP_016876997.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021508.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2702
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2702
                     /product="protein unc-79 homolog isoform X5"
                     /calculated_mol_wt=302547
     Region          159..690
                     /region_name="UNC-79"
                     /note="Cation-channel complex subunit UNC-79; pfam14776"
                     /db_xref="CDD:434201"
     CDS             1..2702
                     /gene="UNC79"
                     /gene_synonym="KIAA1409"
                     /coded_by="XM_017021508.2:3540..11648"
                     /db_xref="GeneID:57578"
                     /db_xref="HGNC:HGNC:19966"
                     /db_xref="MIM:616884"
ORIGIN      
        1 mdsvensvee etretliima pwdlqrgmtr tgsfttarsk vrsgmwtmlv tpvaskiryl
       61 qeyhnrvlhn iypvpsgtdi antlkyfsqt llsilsrtgk kenqdasnlt vpmtmclfpv
      121 pfpltpslrp qvssinptvt rsllysvlrd apsergpqsr daqlsdypsl dyqglyvtlv
      181 tlldlvpllq hgqhdlgqsi fytttcllpf lnddilstlp ytmistlatf ppflhkdiie
      241 ylstsflpma ilgssrregv pahvnlsass mlmiamqyts npvyhcqlle clmkykqevw
      301 kdllyviayg psqvkppavq mlfhywpnlk ppgaiseyrg lqytawnpih cqhiechnai
      361 nkpavkmcid pslsvalgdk ppplylceec seriagdhse wlidvllpqa eisaicqkkn
      421 csshvrravv tcfsagccgr hgnrpvryck rchsnhhsne vgaaaethly qtspppintr
      481 ecgaeelvca veavisllke aefhaeqreh elnrrrqlgl ssshhsldna dfdnkdddkh
      541 dqrllsqfgi wflvslctps entpteslar lvamvfqwfh staymmddev gslveklkpq
      601 fvtkwlktvc dvrfdvmvmc llpkpmefar vggywdkscs tvtqlkegln rilclipynv
      661 inqsvwecim pewleairte vpdnqlkefr evlskmfdie lcplpfsmee mfgfiscrft
      721 gypssvqeqa llwlhvlsel dimvplqlli smfsdgvnsv kelanqrksr vselagnlas
      781 rrvsvasdpg rrvqhnmlsp fhspfqspfr splrspfrsp fknfghpggr tidfdcedde
      841 mnlncfilmf dlllkqmelq ddgitmgleh slskdiisii nnvfqapwgg shtcqkdeka
      901 iecnlcqssi lcyqlacell erlapkeesr lveptdsled sllssrpefi igpegeeeen
      961 paskhgenpg nctepvehaa vkndterkfc yqqlpvtlrl iytifqemak feepdilfnm
     1021 lnclkilclh geclyiarkd hpqflayiqd hmliaslwrv vksefsqlss lavplllhal
     1081 slphgadifw tiingnfnsk dwkmrfeave kvavicrfld ihsvtknhll kyslahafcc
     1141 fltavedvnp avatraglll dtikrpalqg lclcldfqfd tvvkdrptil skllllhflk
     1201 qdipalswef fvnrfetlsl eaqlhldcnk efpfpttita vrtnvanlsd aalwkikrar
     1261 farnrqksvr slrdsvkgpv eskralslpe tltskipmrl trheqsapal ggtpeqtpgq
     1321 qspendntik dllpedagid hqtvhqlitv lmkfmakdes saesdissak afntvkrhly
     1381 vllgydqqeg cfmiapqkmr lstcfnafia giaqvmdyni nlgkhllplv vqvlkycscp
     1441 qlrhyfqqpp rcslwslkph irqmwlkall vilykypyrd cdiskillhl ihitvntlna
     1501 qyhsckphat agplysdnsn isrysekekg eielaeyret galqdsllhc vreesipkkk
     1561 lrsfkqksld ignadsllft ldehrrksci drcdiekppt qaayiaqrpn dpgrsrqnsa
     1621 trpdnseipe npamegfpda rrpvipevrl ncmetfevkv dspvkpapke dldlidlssd
     1681 stsgpekhsi lstsdsdslv feplpplriv esdeeeetmn qgddgpsgkn aasspsvpsh
     1741 psvlslstap lvqvsvedcs kdfsskdsgn nqsagntdsa litledpmda egsskpeelp
     1801 efscgspltl kqkrdllqks falpemsldd hpdpgtegek pgelmpssga ktvllkvped
     1861 aenptesekp dtsaesdteq nperkveedg aeesefkiqi vprqrkqrki avsaiqreyl
     1921 disfnildkl geqkdpdpst kglstlempr esssaptlda gvpetsshss istqyrqmkr
     1981 gslgvltmsq lmkrqlehqs saphnisnwd teqiqpgkrq cnvptclnpd legqplrmrg
     2041 atkssllsap sivsmfvpap eeftdeqptv mtdkchdcga ileeydeetl glaivvlstf
     2101 ihlspdlaap llldimqsvg rlassttfsn qaesmmvpgn aagvakqflr cifhqlapng
     2161 ifpqlfqsti kdgtflrtla sslmdfnels siaalsqlle glnnkknlpa ggamirclen
     2221 iatfmealpm dspsslwtti snqfqtffak lpcvlplkcs ldsslrimic llkipstnat
     2281 rsllepfskl lsfviqnavf tlaylvelcg lcyraftker dkfylsrsvv lellqalklk
     2341 splpdtnlll lvqficadag tklaestils kqmiasvpgc gtaamecvrq yinevldfma
     2401 dmhtltklks hmktcsqplh edtfgghlkv glaqiaamdi srgnhrdnka virylpwlyh
     2461 ppsamqqgpk efiecvshir llswlllgsl thnavcpnas spclpiplda gshvadhliv
     2521 iligfpeqsk tsvlhmcslf hafifaqlwt vyceqsavat nlqnqnefsf tailtalefw
     2581 srvtpsilql mahnkvmvem vclhvislme alqecnstif vklipmwlpm iqsnikhlsa
     2641 glqlrlqaiq nhvnhhslrt lpgsgqssag laalrkwlqc tqfkmaqvei qsseaasqfy
     2701 pl
//
LOCUS       XP_011535324            2700 aa            linear   PRI 05-AUG-2025
DEFINITION  protein unc-79 homolog isoform X6 [Homo sapiens].
ACCESSION   XP_011535324
VERSION     XP_011535324.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537022.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2700
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2700
                     /product="protein unc-79 homolog isoform X6"
                     /calculated_mol_wt=302401
     Region          159..690
                     /region_name="UNC-79"
                     /note="Cation-channel complex subunit UNC-79; pfam14776"
                     /db_xref="CDD:434201"
     CDS             1..2700
                     /gene="UNC79"
                     /gene_synonym="KIAA1409"
                     /coded_by="XM_011537022.3:3540..11642"
                     /db_xref="GeneID:57578"
                     /db_xref="HGNC:HGNC:19966"
                     /db_xref="MIM:616884"
ORIGIN      
        1 mdsvensvee etretliima pwdlqrgmtr tgsfttarsk vrsgmwtmlv tpvaskiryl
       61 qeyhnrvlhn iypvpsgtdi antlkyfsqt llsilsrtgk kenqdasnlt vpmtmclfpv
      121 pfpltpslrp qvssinptvt rsllysvlrd apsergpqsr daqlsdypsl dyqglyvtlv
      181 tlldlvpllq hgqhdlgqsi fytttcllpf lnddilstlp ytmistlatf ppflhkdiie
      241 ylstsflpma ilgssrregv pahvnlsass mlmiamqyts npvyhcqlle clmkykqevw
      301 kdllyviayg psqvkppavq mlfhywpnlk ppgaiseyrg lqytawnpih cqhiechnai
      361 nkpavkmcid pslsvalgdk ppplylceec seriagdhse wlidvllpqa eisaicqkkn
      421 csshvrravv tcfsagccgr hgnrpvryck rchsnhhsne vgaaaethly qtspppintr
      481 ecgaeelvca veavisllke aefhaeqreh elnrrrqlgl ssshhsldna dfdnkdddkh
      541 dqrllsqfgi wflvslctps entpteslar lvamvfqwfh staymmddev gslveklkpq
      601 fvtkwlktvc dvrfdvmvmc llpkpmefar vggywdkscs tvtqlkegln rilclipynv
      661 inqsvwecim pewleairte vpdnqlkefr evlskmfdie lcplpfsmee mfgfiscrft
      721 gypssvqeqa llwlhvlsel dimvplqlli smfsdgvnsv kelanqrksr vselagnlas
      781 rrvsvasdpg rrvqhnmlsp fhspfqspfr splrspfrsp fknfghpggr tidfdcedde
      841 mnlncfilmf dlllkqmelq ddgitmgleh slskdiisii nnvfqapwgg shtcqkdeka
      901 iecnlcqssi lcyqlacell erlapkeesr lveptdsled sllssrpefi igpegeeeen
      961 paskhgenpg nctepvehaa vkndterkfc yqqlpvtlrl iytifqemak feepdilfnm
     1021 lnclkilclh geclyiarkd hpqflayiqd hmliaslwrv vksefsqlss lavplllhal
     1081 slphgadifw tiingnfnsk dwkmrfeave kvavicrfld ihsvtknhll kyslahafcc
     1141 fltavedvnp avatraglll dtikrpalqg lclcldfqfd tvvkdrptil skllllhflk
     1201 qdipalswef fvnrfetlsl eaqlhldcnk efpfpttita vrtnvanlsd aalwkikrar
     1261 farnrqksvr slrdsvkgpv eskralslpe tltskipmrl trheqsapal ggtpeqtpgq
     1321 qspendntik dllpedagid hqtvhqlitv lmkfmakdes saesdissak afntvkrhly
     1381 vllgydqqeg cfmiapqkmr lstcfnafia giaqvmdyni nlgkhllplv vqvlkycscp
     1441 qlrhyfqqpp rcslwslkph irqmwlkall vilykypyrd cdiskillhl ihitvntlna
     1501 qyhsckphat agplysdnsn isrysekeke edsvfdesdi hdtptgpcnk esqtffarlk
     1561 riggskmvky qpvemnvqrn ehrrkscidr cdiekpptqa ayiaqrpndp grsrqnsatr
     1621 pdnseipenp amegfpdarr pvipevrlnc metfevkvds pvkpapkedl dlidlssdst
     1681 sgpekhsils tsdsdslvfe plpplrives deeeetmnqg ddgpsgknaa sspsvpshps
     1741 vlslstaplv qvsvedcskd fsskdsgnnq sagntdsali tledpmdaeg sskpeelpef
     1801 scgspltlkq krdllqksfa lpemslddhp dpgtegekpg elmpssgakt vllkvpedae
     1861 nptesekpdt saesdteqnp erkveedgae esefkiqivp rqrkqrkiav saiqreyldi
     1921 sfnildklge qkdpdpstkg lstlempres ssaptldagv petsshssis tqyrqmkrgs
     1981 lgvltmsqlm krqlehqssa phnisnwdte qiqpgkrqcn vptclnpdle gqplrmrgat
     2041 kssllsapsi vsmfvpapee ftdeqptvmt dkchdcgail eeydeetlgl aivvlstfih
     2101 lspdlaapll ldimqsvgrl assttfsnqa esmmvpgnaa gvakqflrci fhqlapngif
     2161 pqlfqstikd gtflrtlass lmdfnelssi aalsqllegl nnkknlpagg amirclenia
     2221 tfmealpmds psslwttisn qfqtffaklp cvlplkcsld sslrimicll kipstnatrs
     2281 llepfsklls fviqnavftl aylvelcglc yraftkerdk fylsrsvvle llqalklksp
     2341 lpdtnllllv qficadagtk laestilskq miasvpgcgt aamecvrqyi nevldfmadm
     2401 htltklkshm ktcsqplhed tfgghlkvgl aqiaamdisr gnhrdnkavi rylpwlyhpp
     2461 samqqgpkef iecvshirll swlllgslth navcpnassp clpipldags hvadhlivil
     2521 igfpeqskts vlhmcslfha fifaqlwtvy ceqsavatnl qnqnefsfta iltalefwsr
     2581 vtpsilqlma hnkvmvemvc lhvislmeal qecnstifvk lipmwlpmiq snikhlsagl
     2641 qlrlqaiqnh vnhhslrtlp gsgqssagla alrkwlqctq fkmaqveiqs seaasqfypl
//
LOCUS       XP_011535325            2699 aa            linear   PRI 05-AUG-2025
DEFINITION  protein unc-79 homolog isoform X7 [Homo sapiens].
ACCESSION   XP_011535325
VERSION     XP_011535325.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537023.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2699
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2699
                     /product="protein unc-79 homolog isoform X7"
                     /calculated_mol_wt=302476
     Region          106..637
                     /region_name="UNC-79"
                     /note="Cation-channel complex subunit UNC-79; pfam14776"
                     /db_xref="CDD:434201"
     CDS             1..2699
                     /gene="UNC79"
                     /gene_synonym="KIAA1409"
                     /coded_by="XM_011537023.3:3540..11639"
                     /db_xref="GeneID:57578"
                     /db_xref="HGNC:HGNC:19966"
                     /db_xref="MIM:616884"
ORIGIN      
        1 mdsvensvee etretliima pwdlqrgmtr tgsfttarsk vrsgmwtmlv tpvaskiryl
       61 qeyhnrvlhn iypvpsgtdi antlkyfsqt llsvlrdaps ergpqsrdaq lsdypsldyq
      121 glyvtlvtll dlvpllqhgq hdlgqsifyt ttcllpflnd dilstlpytm istlatfppf
      181 lhkdiieyls tsflpmailg ssrregvpah vnlsassmlm iamqytsnpv yhcqlleclm
      241 kykqevwkdl lyviaygpsq vkppavqmlf hywpnlkppg aiseyrglqy tawnpihcqh
      301 iechnainkp avkmcidpsl svalgdkppp lylceecser iagdhsewli dvllpqaeis
      361 aicqkkncss hvrravvtcf sagccgrhgn rpvryckrch snhhsnevga aaethlyqts
      421 pppintrecg aeelvcavea visllkeaef haeqreheln rrrqlglsss hhsldnadfd
      481 nkdddkhdqr llsqfgiwfl vslctpsent pteslarlva mvfqwfhsta ymmddevgsl
      541 veklkpqfvt kwlktvcdvr fdvmvmcllp kpmefarvgg ywdkscstvt qlkeglnril
      601 clipynvinq svwecimpew leairtevpd nqlkefrevl skmfdielcp lpfsmeemfg
      661 fiscrftgyp ssvqeqallw lhvlseldim vplqllismf sdgvnsvkel anqrksrvse
      721 lagnlasrrv svasdpgrrv qhnmlspfhs pfqspfrspl rspfrspfkn fghpggrtid
      781 fdceddemnl ncfilmfdll lkqmelqddg itmglehsls kdiisiinnv fqapwggsht
      841 cqkdekaiec nlcqssilcy qlacellerl apkeesrlve ptdsledsll ssrpefiigp
      901 egeeeenpas khgenpgnct epvehaavkn dterkfcyqq lpvtlrliyt ifqemakfee
      961 pdilfnmlnc lkilclhgec lyiarkdhpq flayiqdhml iaslwrvvks efsqlsslav
     1021 plllhalslp hgadifwtii ngnfnskdwk mrfeavekva vicrfldihs vtknhllkys
     1081 lahafccflt avedvnpava tragllldti krpalqglcl cldfqfdtvv kdrptilskl
     1141 lllhflkqdi palsweffvn rfetlsleaq lhldcnkefp fpttitavrt nvanlsdaal
     1201 wkikrarfar nrqksvrslr dsvkgpvesk ralslpetlt skipmrltrh eqsapalggt
     1261 peqtpgqqsp endntikdll pedagidhqt vhqlitvlmk fmakdessae sdissakafn
     1321 tvkrhlyvll gydqqegcfm iapqkmrlst cfnafiagia qvmdyninlg khllplvvqv
     1381 lkycscpqlr hyfqqpprcs lwslkphirq mwlkallvil ykypyrdcdi skillhlihi
     1441 tvntlnaqyh sckphatagp lysdnsnisr ysekekeeds vfdesdihdt ptgpcnkesq
     1501 tffarlkrig gskmvkyqpv emnvqrseie laeyretgal qdsllhcvre esipkkklrs
     1561 fkqksldign adsllftlde hrrkscidrc diekpptqaa yiaqrpndpg rsrqnsatrp
     1621 dnseipenpa megfpdarrp vipevrlncm etfevkvdsp vkpapkedld lidlssdsts
     1681 gpekhsilst sdsdslvfep lpplrivesd eeeetmnqgd dgpsgknaas spsvpshpsv
     1741 lslstaplvq vsvedcskdf sskdsgnnqs agntdsalit ledpmdaegs skpeelpefs
     1801 cgspltlkqk rdllqksfal pemslddhpd pgtegekpge lmpssgaktv llkvpedaen
     1861 ptesekpdts aesdteqnpe rkveedgaee sefkiqivpr qrkqrkiavs aiqreyldis
     1921 fnildklgeq kdpdpstkgl stlempress saptldagvp etsshssist qyrqmkrgsl
     1981 gvltmsqlmk rqlehqssap hnisnwdteq iqpgkrqcnv ptclnpdleg qplrmrgatk
     2041 ssllsapsiv smfvpapeef tdeqptvmtd kchdcgaile eydeetlgla ivvlstfihl
     2101 spdlaaplll dimqsvgrla ssttfsnqae smmvpgnaag vakqflrcif hqlapngifp
     2161 qlfqstikdg tflrtlassl mdfnelssia alsqllegln nkknlpagga mircleniat
     2221 fmealpmdsp sslwttisnq fqtffaklpc vlplkcslds slrimicllk ipstnatrsl
     2281 lepfskllsf viqnavftla ylvelcglcy raftkerdkf ylsrsvvlel lqalklkspl
     2341 pdtnllllvq ficadagtkl aestilskqm iasvpgcgta amecvrqyin evldfmadmh
     2401 tltklkshmk tcsqplhedt fgghlkvgla qiaamdisrg nhrdnkavir ylpwlyhpps
     2461 amqqgpkefi ecvshirlls wlllgslthn avcpnasspc lpipldagsh vadhlivili
     2521 gfpeqsktsv lhmcslfhaf ifaqlwtvyc eqsavatnlq nqnefsftai ltalefwsrv
     2581 tpsilqlmah nkvmvemvcl hvislmealq ecnstifvkl ipmwlpmiqs nikhlsaglq
     2641 lrlqaiqnhv nhhslrtlpg sgqssaglaa lrkwlqctqf kmaqveiqss eaasqfypl
//
LOCUS       XP_016876998            2699 aa            linear   PRI 05-AUG-2025
DEFINITION  protein unc-79 homolog isoform X8 [Homo sapiens].
ACCESSION   XP_016876998
VERSION     XP_016876998.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021509.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2699
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2699
                     /product="protein unc-79 homolog isoform X8"
                     /calculated_mol_wt=302497
     Region          159..637
                     /region_name="UNC-79"
                     /note="Cation-channel complex subunit UNC-79; pfam14776"
                     /db_xref="CDD:434201"
     CDS             1..2699
                     /gene="UNC79"
                     /gene_synonym="KIAA1409"
                     /coded_by="XM_017021509.2:3540..11639"
                     /db_xref="GeneID:57578"
                     /db_xref="HGNC:HGNC:19966"
                     /db_xref="MIM:616884"
ORIGIN      
        1 mdsvensvee etretliima pwdlqrgmtr tgsfttarsk vrsgmwtmlv tpvaskiryl
       61 qeyhnrvlhn iypvpsgtdi antlkyfsqt llsilsrtgk kenqdasnlt vpmtmclfpv
      121 pfpltpslrp qvssinptvt rsllysvlrd apsergpqsr daqlsdypsl dyqglyvtlv
      181 tlldlvpllq hgqhdlgqsi fytttcllpf lnddilstlp ytmistlatf ppflhkdiie
      241 ylstsflpma ilgssrregv pahvnlsass mlmiamqyts npvyhcqlle clmkykqevw
      301 kdllyviayg psqvkppavq mlfhywpnlk ppgaiseyrg lqytawnpih cqhiechnai
      361 nkpavkncss hvrravvtcf sagccgrhgn rpvryckrch snhhsnevga aaethlyqts
      421 pppintrecg aeelvcavea visllkeaef haeqreheln rrrqlglsss hhsldnadfd
      481 nkdddkhdqr llsqfgiwfl vslctpsent pteslarlva mvfqwfhsta ymmddevgsl
      541 veklkpqfvt kwlktvcdvr fdvmvmcllp kpmefarvgg ywdkscstvt qlkeglnril
      601 clipynvinq svwecimpew leairtevpd nqlkefrevl skmfdielcp lpfsmeemfg
      661 fiscrftgyp ssvqeqallw lhvlseldim vplqllismf sdgvnsvkel anqrksrvse
      721 lagnlasrrv svasdpgrrv qhnmlspfhs pfqspfrspl rspfrspfkn fghpggrtid
      781 fdceddemnl ncfilmfdll lkqmelqddg itmglehsls kdiisiinnv fqapwggsht
      841 cqkdekaiec nlcqssilcy qlacellerl apkeesrlve ptdsledsll ssrpefiigp
      901 egeeeenpas khgenpgnct epvehaavkn dterkfcyqq lpvtlrliyt ifqemakfee
      961 pdilfnmlnc lkilclhgec lyiarkdhpq flayiqdhml iaslwrvvks efsqlsslav
     1021 plllhalslp hgadifwtii ngnfnskdwk mrfeavekva vicrfldihs vtknhllkys
     1081 lahafccflt avedvnpava tragllldti krpalqglcl cldfqfdtvv kdrptilskl
     1141 lllhflkqdi palsweffvn rfetlsleaq lhldcnkefp fpttitavrt nvanlsdaal
     1201 wkikrarfar nrqksvrslr dsvkgpvesk ralslpetlt skipmrltrh eqsapalggt
     1261 peqtpgqqsp endntikdll pedagidhqt vhqlitvlmk fmakdessae sdissakafn
     1321 tvkrhlyvll gydqqegcfm iapqkmrlst cfnafiagia qvmdyninlg khllplvvqv
     1381 lkycscpqlr hyfqqpprcs lwslkphirq mwlkallvil ykypyrdcdi skillhlihi
     1441 tvntlnaqyh sckphatagp lysdnsnisr ysekekeeds vfdesdihdt ptgpcnkesq
     1501 tffarlkrig gskmvkyqpv emnvqrseie laeyretgal qdsllhcvre esipkkklrs
     1561 fkqksldign adsllftlde hrrkscidrc diekpptqaa yiaqrpndpg rsrqnsatrp
     1621 dnseipenpa megfpdarrp vipevrlncm etfevkvdsp vkpapkedld lidlssdsts
     1681 gpekhsilst sdsdslvfep lpplrivesd eeeetmnqgd dgpsgknaas spsvpshpsv
     1741 lslstaplvq vsvedcskdf sskdsgnnqs agntdsalit ledpmdaegs skpeelpefs
     1801 cgspltlkqk rdllqksfal pemslddhpd pgtegekpge lmpssgaktv llkvpedaen
     1861 ptesekpdts aesdteqnpe rkveedgaee sefkiqivpr qrkqrkiavs aiqreyldis
     1921 fnildklgeq kdpdpstkgl stlempress saptldagvp etsshssist qyrqmkrgsl
     1981 gvltmsqlmk rqlehqssap hnisnwdteq iqpgkrqcnv ptclnpdleg qplrmrgatk
     2041 ssllsapsiv smfvpapeef tdeqptvmtd kchdcgaile eydeetlgla ivvlstfihl
     2101 spdlaaplll dimqsvgrla ssttfsnqae smmvpgnaag vakqflrcif hqlapngifp
     2161 qlfqstikdg tflrtlassl mdfnelssia alsqllegln nkknlpagga mircleniat
     2221 fmealpmdsp sslwttisnq fqtffaklpc vlplkcslds slrimicllk ipstnatrsl
     2281 lepfskllsf viqnavftla ylvelcglcy raftkerdkf ylsrsvvlel lqalklkspl
     2341 pdtnllllvq ficadagtkl aestilskqm iasvpgcgta amecvrqyin evldfmadmh
     2401 tltklkshmk tcsqplhedt fgghlkvgla qiaamdisrg nhrdnkavir ylpwlyhpps
     2461 amqqgpkefi ecvshirlls wlllgslthn avcpnasspc lpipldagsh vadhlivili
     2521 gfpeqsktsv lhmcslfhaf ifaqlwtvyc eqsavatnlq nqnefsftai ltalefwsrv
     2581 tpsilqlmah nkvmvemvcl hvislmealq ecnstifvkl ipmwlpmiqs nikhlsaglq
     2641 lrlqaiqnhv nhhslrtlpg sgqssaglaa lrkwlqctqf kmaqveiqss eaasqfypl
//
LOCUS       XP_024305435            2696 aa            linear   PRI 05-AUG-2025
DEFINITION  protein unc-79 homolog isoform X9 [Homo sapiens].
ACCESSION   XP_024305435
VERSION     XP_024305435.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449667.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2696
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2696
                     /product="protein unc-79 homolog isoform X9"
                     /calculated_mol_wt=302004
     Region          159..690
                     /region_name="UNC-79"
                     /note="Cation-channel complex subunit UNC-79; pfam14776"
                     /db_xref="CDD:434201"
     CDS             1..2696
                     /gene="UNC79"
                     /gene_synonym="KIAA1409"
                     /coded_by="XM_024449667.2:3540..11630"
                     /db_xref="GeneID:57578"
                     /db_xref="HGNC:HGNC:19966"
                     /db_xref="MIM:616884"
ORIGIN      
        1 mdsvensvee etretliima pwdlqrgmtr tgsfttarsk vrsgmwtmlv tpvaskiryl
       61 qeyhnrvlhn iypvpsgtdi antlkyfsqt llsilsrtgk kenqdasnlt vpmtmclfpv
      121 pfpltpslrp qvssinptvt rsllysvlrd apsergpqsr daqlsdypsl dyqglyvtlv
      181 tlldlvpllq hgqhdlgqsi fytttcllpf lnddilstlp ytmistlatf ppflhkdiie
      241 ylstsflpma ilgssrregv pahvnlsass mlmiamqyts npvyhcqlle clmkykqevw
      301 kdllyviayg psqvkppavq mlfhywpnlk ppgaiseyrg lqytawnpih cqhiechnai
      361 nkpavkmcid pslsvalgdk ppplylceec seriagdhse wlidvllpqa eisaicqkkn
      421 csshvrravv tcfsagccgr hgnrpvryck rchsnhhsne vgaaaethly qtspppintr
      481 ecgaeelvca veavisllke aefhaeqreh elnrrrqlgl ssshhsldna dfdnkdddkh
      541 dqrllsqfgi wflvslctps entpteslar lvamvfqwfh staymmddev gslveklkpq
      601 fvtkwlktvc dvrfdvmvmc llpkpmefar vggywdkscs tvtqlkegln rilclipynv
      661 inqsvwecim pewleairte vpdnqlkefr evlskmfdie lcplpfsmee mfgfiscrft
      721 gypssvqeqa llwlhvlsel dimvplqlli smfsdgvnsv kelanqrksr vselagnlas
      781 rrvsvasdpg rrvqhnmlsp fhspfqspfr splrspfrsp fknfghpggr tidfdcedde
      841 mnlncfilmf dlllkqmelq ddgitmgleh slskdiisii nnvfqapwgg shtcqkdeka
      901 iecnlcqssi lcyqlacell erlapkeesr lveptdsled sllssrpefi igpegeeeen
      961 paskhgenpg nctepvehaa vkndterkfc yqqlpvtlrl iytifqemak feepdilfnm
     1021 lnclkilclh geclyiarkd hpqflayiqd hmliaslwrv vksefsqlss lavplllhal
     1081 slphgadifw tiingnfnsk dwkmrfeave kvavicrfld ihsvtknhll kyslahafcc
     1141 fltavedvnp avatraglll dtikrpalqg lclcldfqfd tvvkdrptil skllllhflk
     1201 qdipalswef fvnrfetlsl eaqlhldcnk efpfpttita vrtnvanlsd aalwkikrar
     1261 farnrqksvr slrdsvkgpv eskralslpe tltskirqqs pendntikdl lpedagidhq
     1321 tvhqlitvlm kfmakdessa esdissakaf ntvkrhlyvl lgydqqegcf miapqkmrls
     1381 tcfnafiagi aqpprcslws lkphirqmwl kallvilyky pyrdcdiski llhlihitvn
     1441 tlnaqyhsck phatagplys dnsnisryse kekeedsvfd esdihdtptg pcnkesqtff
     1501 arlkriggsk mvkyqpvemn vqrseielae yretgalqds llhcvreesi pkkklrsfkq
     1561 ksldignads llftldehrr kscidrcdie kpptqaayia qrpndpgrsr qnsatrpdns
     1621 eipenpameg fpdarrpvip evrlncmetf evkvdspvkp apkedldlid lssdstsgpe
     1681 khsilstsds dslvfeplpp lrivesdeee etmnqgddgp sgknaassps vpshpsvlsl
     1741 staplvqvsv edcskdfssk dsgnnqsagn tdsalitled pmdaegsskp eelpefscgs
     1801 pltlkqkrdl lqksfalpem slddhpdpgt egekpgelmp ssgaktvllk vpedaenpte
     1861 sekpdtsaes dteqnperkv eedgaeesef kiqivprqrk qrkiavsaiq reyldisfni
     1921 ldklgeqkdp dpstkglstl empresssap tldagvpets shssistqyr qmkrgslgvl
     1981 tmsqlmkrql ehqssaphni snwdteqiqp gkrqcnvptc lnpdlegqpl rmrgatkssl
     2041 lsapsivsmf vpapeeftde qptvmtdkch dcgaileeyd eetlglaivv lstfihlspd
     2101 laapllldim qsvgrlasst tfsnqaesmm vpgnaagvak qflrcifhql apngifpqlf
     2161 qstikdgtfl rtlasslmdf nelssiaals qlleglnnkk nlpaggamir cleniatfme
     2221 alpmdspssl wttisnqfqt ffaklpcvlp lkcsldsslr imicllkips tnatrsllep
     2281 fskllsfviq navftlaylv elcglcyraf tkerdkfyls rsvvlellqa lklksplpdt
     2341 nllllvqfic adagtklaes tilskqmias vpgcgtaame cvrqyinevl dfmadmhtlt
     2401 klkshmktcs qplhedtfgg hlkvglaqia amdisrgnhr dnkavirylp wlyhppsamq
     2461 qgpkefiecv shirllswll lgslthnavc pnasspclpi pldagshvad hliviligfp
     2521 eqsktsvlhm cslfhafifa qlwtvyceqs avatnlqnqn efsftailta lefwsrvtps
     2581 ilqlmahnkv mvemvclhvi slmealqecn stifvklipm wlpmiqsnik hlsaglqlrl
     2641 qaiqnhvnhh slrtlpgsgq ssaglaalrk wlqctqfkma qveiqsseaa sqfypl
//
LOCUS       XP_016876999            2691 aa            linear   PRI 05-AUG-2025
DEFINITION  protein unc-79 homolog isoform X10 [Homo sapiens].
ACCESSION   XP_016876999
VERSION     XP_016876999.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021510.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2691
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2691
                     /product="protein unc-79 homolog isoform X10"
                     /calculated_mol_wt=301506
     Region          159..690
                     /region_name="UNC-79"
                     /note="Cation-channel complex subunit UNC-79; pfam14776"
                     /db_xref="CDD:434201"
     CDS             1..2691
                     /gene="UNC79"
                     /gene_synonym="KIAA1409"
                     /coded_by="XM_017021510.2:3540..11615"
                     /db_xref="GeneID:57578"
                     /db_xref="HGNC:HGNC:19966"
                     /db_xref="MIM:616884"
ORIGIN      
        1 mdsvensvee etretliima pwdlqrgmtr tgsfttarsk vrsgmwtmlv tpvaskiryl
       61 qeyhnrvlhn iypvpsgtdi antlkyfsqt llsilsrtgk kenqdasnlt vpmtmclfpv
      121 pfpltpslrp qvssinptvt rsllysvlrd apsergpqsr daqlsdypsl dyqglyvtlv
      181 tlldlvpllq hgqhdlgqsi fytttcllpf lnddilstlp ytmistlatf ppflhkdiie
      241 ylstsflpma ilgssrregv pahvnlsass mlmiamqyts npvyhcqlle clmkykqevw
      301 kdllyviayg psqvkppavq mlfhywpnlk ppgaiseyrg lqytawnpih cqhiechnai
      361 nkpavkmcid pslsvalgdk ppplylceec seriagdhse wlidvllpqa eisaicqkkn
      421 csshvrravv tcfsagccgr hgnrpvryck rchsnhhsne vgaaaethly qtspppintr
      481 ecgaeelvca veavisllke aefhaeqreh elnrrrqlgl ssshhsldna dfdnkdddkh
      541 dqrllsqfgi wflvslctps entpteslar lvamvfqwfh staymmddev gslveklkpq
      601 fvtkwlktvc dvrfdvmvmc llpkpmefar vggywdkscs tvtqlkegln rilclipynv
      661 inqsvwecim pewleairte vpdnqlkefr evlskmfdie lcplpfsmee mfgfiscrft
      721 gypssvqeqa llwlhvlsel dimvplqlli smfsdgvnsv kelanqrksr vselagnlas
      781 rrvsvasdpg rrvqhnmlsp fhspfqspfr splrspfrsp fknfghpggr tidfdcedde
      841 mnlncfilmf dlllkqmelq ddgitmgleh slskdiisii nnvfqapwgg shtcqkdeka
      901 iecnlcqssi lcyqlacell erlapkeesr lveptdsled sllssrpefi igpegeeeen
      961 paskhgenpg nctepvehaa vkndterkfc yqqlpvtlrl iytifqemak feepdilfnm
     1021 lnclkilclh geclyiarkd hpqflayiqd hmliaslwrv vksefsqlss lavplllhal
     1081 slphgadifw tiingnfnsk dwkmrfeave kvavicrfld ihsvtknhll kyslahafcc
     1141 fltavedvnp avatraglll dtikrpalqg lclcldfqfd tvvkdrptil skllllhflk
     1201 qdipalswef fvnrfetlsl eaqlhldcnk efpfpttita vrtnvanlsd aalwkikrar
     1261 farnrqksvr slrdsvkgpv eskralslpe tltskirqqs pendntikdl lpedagidhq
     1321 tvhqlitvlm kfmakdessa esdissakaf ntvkrhlyvl lgydqqegcf miapqkmrls
     1381 tcfnafiagi aqvmdyninl gkhllplvvq vlkycscpql rhyfqqpprc slwslkphir
     1441 qmwlkallvi lykypyrdcd iskillhlih itvntlnaqy hsckphatag plysdnsnis
     1501 rysekekeed svfdesdihd tptgpcnkes qtffarlkri ggskmvkyqp vemnvqrsei
     1561 elaeyretga lqdsllhcvr eesipkkklr sfkqksldig nadsllftld ehrrkscidr
     1621 cdiekpptqa ayiaqrpndp grsrqnsatr pdnseipenp amegfpdarr pvipevrlnc
     1681 metfevkvds pvkpapkedl dlidlssdst sgpekhsils tsdsdslvfe plpplrives
     1741 deeeetmnqg ddgpsgknaa sspsvpshps vlslstaplv qvsvedcskd fsskdsgnnq
     1801 sagntdsali tledpmdaeg sskpeelpef scgspltlkq krdllqksfa lpemslddhp
     1861 dpgtegekpg elmpssgakt vllkvpedae nptesekpdt saesdteqnp erkveedgae
     1921 esefkiqivp rqrkqrkiav saiqreyldi sfnildklge qkdpdpstkg lstlempres
     1981 ssaptldagv petsshssis kqiqpgkrqc nvptclnpdl egqplrmrga tkssllsaps
     2041 ivsmfvpape eftdeqptvm tdkchdcgai leeydeetlg laivvlstfi hlspdlaapl
     2101 lldimqsvgr lassttfsnq aesmmvpgna agvakqflrc ifhqlapngi fpqlfqstik
     2161 dgtflrtlas slmdfnelss iaalsqlleg lnnkknlpag gamircleni atfmealpmd
     2221 spsslwttis nqfqtffakl pcvlplkcsl dsslrimicl lkipstnatr sllepfskll
     2281 sfviqnavft laylvelcgl cyraftkerd kfylsrsvvl ellqalklks plpdtnllll
     2341 vqficadagt klaestilsk qmiasvpgcg taamecvrqy inevldfmad mhtltklksh
     2401 mktcsqplhe dtfgghlkvg laqiaamdis rgnhrdnkav irylpwlyhp psamqqgpke
     2461 fiecvshirl lswlllgslt hnavcpnass pclpipldag shvadhlivi ligfpeqskt
     2521 svlhmcslfh afifaqlwtv yceqsavatn lqnqnefsft ailtalefws rvtpsilqlm
     2581 ahnkvmvemv clhvislmea lqecnstifv klipmwlpmi qsnikhlsag lqlrlqaiqn
     2641 hvnhhslrtl pgsgqssagl aalrkwlqct qfkmaqveiq sseaasqfyp l
//
LOCUS       XP_047287578            2690 aa            linear   PRI 05-AUG-2025
DEFINITION  protein unc-79 homolog isoform X11 [Homo sapiens].
ACCESSION   XP_047287578
VERSION     XP_047287578.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431622.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2690
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2690
                     /product="protein unc-79 homolog isoform X11"
                     /calculated_mol_wt=300977
     Region          159..628
                     /region_name="UNC-79"
                     /note="Cation-channel complex subunit UNC-79; pfam14776"
                     /db_xref="CDD:434201"
     CDS             1..2690
                     /gene="UNC79"
                     /gene_synonym="KIAA1409"
                     /coded_by="XM_047431622.1:3540..11612"
                     /db_xref="GeneID:57578"
                     /db_xref="HGNC:HGNC:19966"
                     /db_xref="MIM:616884"
ORIGIN      
        1 mdsvensvee etretliima pwdlqrgmtr tgsfttarsk vrsgmwtmlv tpvaskiryl
       61 qeyhnrvlhn iypvpsgtdi antlkyfsqt llsilsrtgk kenqdasnlt vpmtmclfpv
      121 pfpltpslrp qvssinptvt rsllysvlrd apsergpqsr daqlsdypsl dyqglyvtlv
      181 tlldlvpllq hgqhdlgqsi fytttcllpf lnddilstlp ytmistlatf ppflhkdiie
      241 ylstsflpma ilgssrregv pahvnlsass mlmiamqyts npawnpihcq hiechnaink
      301 pavkmcidps lsvalgdkpp plylceecse riagdhsewl idvllpqaei saicqkkncs
      361 shvrravvtc fsagccgrhg nrpvryckrc hsnhhsnevg aaaethlyqt spppintrec
      421 gaeelvcave avisllkeae fhaeqrehel nrrrqlglss shhsldnadf dnkdddkhdq
      481 rllsqfgiwf lvslctpsen tpteslarlv amvfqwfhst aymmddevgs lveklkpqfv
      541 tkwlktvcdv rfdvmvmcll pkpmefarvg gywdkscstv tqlkeglnri lclipynvin
      601 qsvwecimpe wleairtevp dnqlkefrev lskmfdielc plpfsmeemf gfiscrftgy
      661 pssvqeqall wlhvlseldi mvplqllism fsdgvnsvke lanqrksrvs elagnlasrr
      721 vsvasdpgrr vqhnmlspfh spfqspfrsp lrspfrspfk nfghpggrti dfdceddemn
      781 lncfilmfdl llkqmelqdd gitmglehsl skdiisiinn vfqapwggsh tcqkdekaie
      841 cnlcqssilc yqlaceller lapkeesrlv eptdsledsl lssrpefiig pegeeeenpa
      901 skhgenpgnc tepvehaavk ndterkfcyq qlpvtlrliy tifqemakfe epdilfnmln
      961 clkilclhge clyiarkdhp qflayiqdhm liaslwrvvk sefsqlssla vplllhalsl
     1021 phgadifwti ingnfnskdw kmrfeavekv avicrfldih svtknhllky slahafccfl
     1081 tavedvnpav atragllldt ikrpalqglc lcldfqfdtv vkdrptilsk llllhflkqd
     1141 ipalsweffv nrfetlslea qlhldcnkef pfpttitavr tnvanlsdaa lwkikrarfa
     1201 rnrqksvrsl rdsvkgpves kralslpetl tskipmrltr heqsapalgg tpeqtpgqqs
     1261 pendntikdl lpedagidhq tvhqlitvlm kfmakdessa esdissakaf ntvkrhlyvl
     1321 lgydqqegcf miapqkmrls tcfnafiagi aqvmdyninl gkhllplvvq vlkycscpql
     1381 rhyfqqpprc slwslkphir qmwlkallvi lykypyrdcd iskillhlih itvntlnaqy
     1441 hsckphatag plysdnsnis rysekekeed svfdesdihd tptgpcnkes qtffarlkri
     1501 ggskmvkyqp vemnvqrsei elaeyretga lqdsllhcvr eesipkkklr sfkqksldig
     1561 nadsllftld ehrrkscidr cdiekpptqa ayiaqrpndp grsrqnsatr pdnseipenp
     1621 amegfpdarr pvipevrlnc metfevkvds pvkpapkedl dlidlssdst sgpekhsils
     1681 tsdsdslvfe plpplrives deeeetmnqg ddgpsgknaa sspsvpshps vlslstaplv
     1741 qvsvedcskd fsskdsgnnq sagntdsali tledpmdaeg sskpeelpef scgspltlkq
     1801 krdllqksfa lpemslddhp dpgtegekpg elmpssgakt vllkvpedae nptesekpdt
     1861 saesdteqnp erkveedgae esefkiqivp rqrkqrkiav saiqreyldi sfnildklge
     1921 qkdpdpstkg lstlempres ssaptldagv petsshssis tqyrqmkrgs lgvltmsqlm
     1981 krqlehqssa phnisnwdte qiqpgkrqcn vptclnpdle gqplrmrgat kssllsapsi
     2041 vsmfvpapee ftdeqptvmt dkchdcgail eeydeetlgl aivvlstfih lspdlaapll
     2101 ldimqsvgrl assttfsnqa esmmvpgnaa gvakqflrci fhqlapngif pqlfqstikd
     2161 gtflrtlass lmdfnelssi aalsqllegl nnkknlpagg amirclenia tfmealpmds
     2221 psslwttisn qfqtffaklp cvlplkcsld sslrimicll kipstnatrs llepfsklls
     2281 fviqnavftl aylvelcglc yraftkerdk fylsrsvvle llqalklksp lpdtnllllv
     2341 qficadagtk laestilskq miasvpgcgt aamecvrqyi nevldfmadm htltklkshm
     2401 ktcsqplhed tfgghlkvgl aqiaamdisr gnhrdnkavi rylpwlyhpp samqqgpkef
     2461 iecvshirll swlllgslth navcpnassp clpipldags hvadhlivil igfpeqskts
     2521 vlhmcslfha fifaqlwtvy ceqsavatnl qnqnefsfta iltalefwsr vtpsilqlma
     2581 hnkvmvemvc lhvislmeal qecnstifvk lipmwlpmiq snikhlsagl qlrlqaiqnh
     2641 vnhhslrtlp gsgqssagla alrkwlqctq fkmaqveiqs seaasqfypl
//
LOCUS       XP_016877002            2680 aa            linear   PRI 05-AUG-2025
DEFINITION  protein unc-79 homolog isoform X12 [Homo sapiens].
ACCESSION   XP_016877002
VERSION     XP_016877002.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021513.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2680
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2680
                     /product="protein unc-79 homolog isoform X12"
                     /calculated_mol_wt=300290
     Region          159..690
                     /region_name="UNC-79"
                     /note="Cation-channel complex subunit UNC-79; pfam14776"
                     /db_xref="CDD:434201"
     CDS             1..2680
                     /gene="UNC79"
                     /gene_synonym="KIAA1409"
                     /coded_by="XM_017021513.2:3540..11582"
                     /db_xref="GeneID:57578"
                     /db_xref="HGNC:HGNC:19966"
                     /db_xref="MIM:616884"
ORIGIN      
        1 mdsvensvee etretliima pwdlqrgmtr tgsfttarsk vrsgmwtmlv tpvaskiryl
       61 qeyhnrvlhn iypvpsgtdi antlkyfsqt llsilsrtgk kenqdasnlt vpmtmclfpv
      121 pfpltpslrp qvssinptvt rsllysvlrd apsergpqsr daqlsdypsl dyqglyvtlv
      181 tlldlvpllq hgqhdlgqsi fytttcllpf lnddilstlp ytmistlatf ppflhkdiie
      241 ylstsflpma ilgssrregv pahvnlsass mlmiamqyts npvyhcqlle clmkykqevw
      301 kdllyviayg psqvkppavq mlfhywpnlk ppgaiseyrg lqytawnpih cqhiechnai
      361 nkpavkmcid pslsvalgdk ppplylceec seriagdhse wlidvllpqa eisaicqkkn
      421 csshvrravv tcfsagccgr hgnrpvryck rchsnhhsne vgaaaethly qtspppintr
      481 ecgaeelvca veavisllke aefhaeqreh elnrrrqlgl ssshhsldna dfdnkdddkh
      541 dqrllsqfgi wflvslctps entpteslar lvamvfqwfh staymmddev gslveklkpq
      601 fvtkwlktvc dvrfdvmvmc llpkpmefar vggywdkscs tvtqlkegln rilclipynv
      661 inqsvwecim pewleairte vpdnqlkefr evlskmfdie lcplpfsmee mfgfiscrft
      721 gypssvqeqa llwlhvlsel dimvplqlli smfsdgvnsv kelanqrksr vselagnlas
      781 rrvsvasdpg rrvqhnmlsp fhspfqspfr splrspfrsp fknfghpggr tidfdcedde
      841 mnlncfilmf dlllkqmelq ddgitmgleh slskdiisii nnvfqapwgg shtcqkdeka
      901 iecnlcqssi lcyqlacell erlapkeesr lveptdsled sllssrpefi igpegeeeen
      961 paskhgenpg nctepvehaa vkndterkfc yqqlpvtlrl iytifqemak feepdilfnm
     1021 lnclkilclh geclyiarkd hpqflayiqd hmliaslwrv vksefsqlss lavplllhal
     1081 slphgadifw tiingnfnsk dwkmrfeave kvavicrfld ihsvtknhll kyslahafcc
     1141 fltavedvnp avatraglll dtikrpalqg lclcldfqfd tvvkdrptil skllllhflk
     1201 qdipalswef fvnrfetlsl eaqlhldcnk efpfpttita vrtnvanlsd aalwkikrar
     1261 farnrqksvr slrdsvkgpv eskralslpe tltskirqqs pendntikdl lpedagidhq
     1321 tvhqlitvlm kfmakdessa esdissakaf ntvkrhlyvl lgydqqegcf miapqkmrls
     1381 tcfnafiagi aqvmdyninl gkhllplvvq vlkycscpql rhyfqqpprc slwslkphir
     1441 qmwlkallvi lykypyrdcd iskillhlih itvntlnaqy hsckphatag plysdnsnis
     1501 rysekekgei elaeyretga lqdsllhcvr eesipkkklr sfkqksldig nadsllftld
     1561 ehrrkscidr cdiekpptqa ayiaqrpndp grsrqnsatr pdnseipenp amegfpdarr
     1621 pvipevrlnc metfevkvds pvkpapkedl dlidlssdst sgpekhsils tsdsdslvfe
     1681 plpplrives deeeetmnqg ddgpsgknaa sspsvpshps vlslstaplv qvsvedcskd
     1741 fsskdsgnnq sagntdsali tledpmdaeg sskpeelpef scgspltlkq krdllqksfa
     1801 lpemslddhp dpgtegekpg elmpssgakt vllkvpedae nptesekpdt saesdteqnp
     1861 erkveedgae esefkiqivp rqrkqrkiav saiqreyldi sfnildklge qkdpdpstkg
     1921 lstlempres ssaptldagv petsshssis tqyrqmkrgs lgvltmsqlm krqlehqssa
     1981 phnisnwdte qiqpgkrqcn vptclnpdle gqplrmrgat kssllsapsi vsmfvpapee
     2041 ftdeqptvmt dkchdcgail eeydeetlgl aivvlstfih lspdlaapll ldimqsvgrl
     2101 assttfsnqa esmmvpgnaa gvakqflrci fhqlapngif pqlfqstikd gtflrtlass
     2161 lmdfnelssi aalsqllegl nnkknlpagg amirclenia tfmealpmds psslwttisn
     2221 qfqtffaklp cvlplkcsld sslrimicll kipstnatrs llepfsklls fviqnavftl
     2281 aylvelcglc yraftkerdk fylsrsvvle llqalklksp lpdtnllllv qficadagtk
     2341 laestilskq miasvpgcgt aamecvrqyi nevldfmadm htltklkshm ktcsqplhed
     2401 tfgghlkvgl aqiaamdisr gnhrdnkavi rylpwlyhpp samqqgpkef iecvshirll
     2461 swlllgslth navcpnassp clpipldags hvadhlivil igfpeqskts vlhmcslfha
     2521 fifaqlwtvy ceqsavatnl qnqnefsfta iltalefwsr vtpsilqlma hnkvmvemvc
     2581 lhvislmeal qecnstifvk lipmwlpmiq snikhlsagl qlrlqaiqnh vnhhslrtlp
     2641 gsgqssagla alrkwlqctq fkmaqveiqs seaasqfypl
//
LOCUS       XP_011535326            2678 aa            linear   PRI 05-AUG-2025
DEFINITION  protein unc-79 homolog isoform X13 [Homo sapiens].
ACCESSION   XP_011535326
VERSION     XP_011535326.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537024.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2678
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2678
                     /product="protein unc-79 homolog isoform X13"
                     /calculated_mol_wt=299797
     Region          159..690
                     /region_name="UNC-79"
                     /note="Cation-channel complex subunit UNC-79; pfam14776"
                     /db_xref="CDD:434201"
     CDS             1..2678
                     /gene="UNC79"
                     /gene_synonym="KIAA1409"
                     /coded_by="XM_011537024.3:3540..11576"
                     /db_xref="GeneID:57578"
                     /db_xref="HGNC:HGNC:19966"
                     /db_xref="MIM:616884"
ORIGIN      
        1 mdsvensvee etretliima pwdlqrgmtr tgsfttarsk vrsgmwtmlv tpvaskiryl
       61 qeyhnrvlhn iypvpsgtdi antlkyfsqt llsilsrtgk kenqdasnlt vpmtmclfpv
      121 pfpltpslrp qvssinptvt rsllysvlrd apsergpqsr daqlsdypsl dyqglyvtlv
      181 tlldlvpllq hgqhdlgqsi fytttcllpf lnddilstlp ytmistlatf ppflhkdiie
      241 ylstsflpma ilgssrregv pahvnlsass mlmiamqyts npvyhcqlle clmkykqevw
      301 kdllyviayg psqvkppavq mlfhywpnlk ppgaiseyrg lqytawnpih cqhiechnai
      361 nkpavkmcid pslsvalgdk ppplylceec seriagdhse wlidvllpqa eisaicqkkn
      421 csshvrravv tcfsagccgr hgnrpvryck rchsnhhsne vgaaaethly qtspppintr
      481 ecgaeelvca veavisllke aefhaeqreh elnrrrqlgl ssshhsldna dfdnkdddkh
      541 dqrllsqfgi wflvslctps entpteslar lvamvfqwfh staymmddev gslveklkpq
      601 fvtkwlktvc dvrfdvmvmc llpkpmefar vggywdkscs tvtqlkegln rilclipynv
      661 inqsvwecim pewleairte vpdnqlkefr evlskmfdie lcplpfsmee mfgfiscrft
      721 gypssvqeqa llwlhvlsel dimvplqlli smfsdgvnsv kelanqrksr vselagnlas
      781 rrmelqddgi tmglehslsk diisiinnvf qapwggshtc qkdekaiecn lcqssilcyq
      841 lacellerla pkeesrlvep tdsledslls srpefiigpe geeeenpask hgenpgncte
      901 pvehaavknd terkfcyqql pvtlrliyti fqemakfeep dilfnmlncl kilclhgecl
      961 yiarkdhpqf layiqdhmli aslwrvvkse fsqlsslavp lllhalslph gadifwtiin
     1021 gnfnskdwkm rfeavekvav icrfldihsv tknhllkysl ahafccflta vedvnpavat
     1081 ragllldtik rpalqglclc ldfqfdtvvk drptilskll llhflkqdip alsweffvnr
     1141 fetlsleaql hldcnkefpf pttitavrtn vanlsdaalw kikrarfarn rqksvrslrd
     1201 svkgpveskr alslpetlts kipmrltrhe qsapalggtp eqtpgqqspe ndntikdllp
     1261 edagidhqtv hqlitvlmkf makdessaes dissakafnt vkrhlyvllg ydqqegcfmi
     1321 apqkmrlstc fnafiagiaq vmdyninlgk hllplvvqvl kycscpqlrh yfqqpprcsl
     1381 wslkphirqm wlkallvily kypyrdcdis killhlihit vntlnaqyhs ckphatagpl
     1441 ysdnsnisry sekekeedsv fdesdihdtp tgpcnkesqt ffarlkrigg skmvkyqpve
     1501 mnvqrseiel aeyretgalq dsllhcvree sipkkklrsf kqksldigna dsllftldeh
     1561 rrkscidrcd iekpptqaay iaqrpndpgr srqnsatrpd nseipenpam egfpdarrpv
     1621 ipevrlncme tfevkvdspv kpapkedldl idlssdstsg pekhsilsts dsdslvfepl
     1681 pplrivesde eeetmnqgdd gpsgknaass psvpshpsvl slstaplvqv svedcskdfs
     1741 skdsgnnqsa gntdsalitl edpmdaegss kpeelpefsc gspltlkqkr dllqksfalp
     1801 emslddhpdp gtegekpgel mpssgaktvl lkvpedaenp tesekpdtsa esdteqnper
     1861 kveedgaees efkiqivprq rkqrkiavsa iqreyldisf nildklgeqk dpdpstkgls
     1921 tlempresss aptldagvpe tsshssistq yrqmkrgslg vltmsqlmkr qlehqssaph
     1981 nisnwdteqi qpgkrqcnvp tclnpdlegq plrmrgatks sllsapsivs mfvpapeeft
     2041 deqptvmtdk chdcgailee ydeetlglai vvlstfihls pdlaapllld imqsvgrlas
     2101 sttfsnqaes mmvpgnaagv akqflrcifh qlapngifpq lfqstikdgt flrtlasslm
     2161 dfnelssiaa lsqlleglnn kknlpaggam ircleniatf mealpmdsps slwttisnqf
     2221 qtffaklpcv lplkcsldss lrimicllki pstnatrsll epfskllsfv iqnavftlay
     2281 lvelcglcyr aftkerdkfy lsrsvvlell qalklksplp dtnllllvqf icadagtkla
     2341 estilskqmi asvpgcgtaa mecvrqyine vldfmadmht ltklkshmkt csqplhedtf
     2401 gghlkvglaq iaamdisrgn hrdnkaviry lpwlyhppsa mqqgpkefie cvshirllsw
     2461 lllgslthna vcpnasspcl pipldagshv adhlivilig fpeqsktsvl hmcslfhafi
     2521 faqlwtvyce qsavatnlqn qnefsftail talefwsrvt psilqlmahn kvmvemvclh
     2581 vislmealqe cnstifvkli pmwlpmiqsn ikhlsaglql rlqaiqnhvn hhslrtlpgs
     2641 gqssaglaal rkwlqctqfk maqveiqsse aasqfypl
//
LOCUS       XP_047287579            2677 aa            linear   PRI 05-AUG-2025
DEFINITION  protein unc-79 homolog isoform X14 [Homo sapiens].
ACCESSION   XP_047287579
VERSION     XP_047287579.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431623.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2677
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2677
                     /product="protein unc-79 homolog isoform X14"
                     /calculated_mol_wt=300218
     Region          106..637
                     /region_name="UNC-79"
                     /note="Cation-channel complex subunit UNC-79; pfam14776"
                     /db_xref="CDD:434201"
     CDS             1..2677
                     /gene="UNC79"
                     /gene_synonym="KIAA1409"
                     /coded_by="XM_047431623.1:3540..11573"
                     /db_xref="GeneID:57578"
                     /db_xref="HGNC:HGNC:19966"
                     /db_xref="MIM:616884"
ORIGIN      
        1 mdsvensvee etretliima pwdlqrgmtr tgsfttarsk vrsgmwtmlv tpvaskiryl
       61 qeyhnrvlhn iypvpsgtdi antlkyfsqt llsvlrdaps ergpqsrdaq lsdypsldyq
      121 glyvtlvtll dlvpllqhgq hdlgqsifyt ttcllpflnd dilstlpytm istlatfppf
      181 lhkdiieyls tsflpmailg ssrregvpah vnlsassmlm iamqytsnpv yhcqlleclm
      241 kykqevwkdl lyviaygpsq vkppavqmlf hywpnlkppg aiseyrglqy tawnpihcqh
      301 iechnainkp avkmcidpsl svalgdkppp lylceecser iagdhsewli dvllpqaeis
      361 aicqkkncss hvrravvtcf sagccgrhgn rpvryckrch snhhsnevga aaethlyqts
      421 pppintrecg aeelvcavea visllkeaef haeqreheln rrrqlglsss hhsldnadfd
      481 nkdddkhdqr llsqfgiwfl vslctpsent pteslarlva mvfqwfhsta ymmddevgsl
      541 veklkpqfvt kwlktvcdvr fdvmvmcllp kpmefarvgg ywdkscstvt qlkeglnril
      601 clipynvinq svwecimpew leairtevpd nqlkefrevl skmfdielcp lpfsmeemfg
      661 fiscrftgyp ssvqeqallw lhvlseldim vplqllismf sdgvnsvkel anqrksrvse
      721 lagnlasrrv svasdpgrrv qhnmlspfhs pfqspfrspl rspfrspfkn fghpggrtid
      781 fdceddemnl ncfilmfdll lkqmelqddg itmglehsls kdiisiinnv fqapwggsht
      841 cqkdekaiec nlcqssilcy qlacellerl apkeesrlve ptdsledsll ssrpefiigp
      901 egeeeenpas khgenpgnct epvehaavkn dterkfcyqq lpvtlrliyt ifqemakfee
      961 pdilfnmlnc lkilclhgec lyiarkdhpq flayiqdhml iaslwrvvks efsqlsslav
     1021 plllhalslp hgadifwtii ngnfnskdwk mrfeavekva vicrfldihs vtknhllkys
     1081 lahafccflt avedvnpava tragllldti krpalqglcl cldfqfdtvv kdrptilskl
     1141 lllhflkqdi palsweffvn rfetlsleaq lhldcnkefp fpttitavrt nvanlsdaal
     1201 wkikrarfar nrqksvrslr dsvkgpvesk ralslpetlt skirqqspen dntikdllpe
     1261 dagidhqtvh qlitvlmkfm akdessaesd issakafntv krhlyvllgy dqqegcfmia
     1321 pqkmrlstcf nafiagiaqv mdyninlgkh llplvvqvlk ycscpqlrhy fqqpprcslw
     1381 slkphirqmw lkallvilyk ypyrdcdisk illhlihitv ntlnaqyhsc kphatagply
     1441 sdnsnisrys ekekeedsvf desdihdtpt gpcnkesqtf farlkriggs kmvkyqpvem
     1501 nvqrseiela eyretgalqd sllhcvrees ipkkklrsfk qksldignad sllftldehr
     1561 rkscidrcdi ekpptqaayi aqrpndpgrs rqnsatrpdn seipenpame gfpdarrpvi
     1621 pevrlncmet fevkvdspvk papkedldli dlssdstsgp ekhsilstsd sdslvfeplp
     1681 plrivesdee eetmnqgddg psgknaassp svpshpsvls lstaplvqvs vedcskdfss
     1741 kdsgnnqsag ntdsalitle dpmdaegssk peelpefscg spltlkqkrd llqksfalpe
     1801 mslddhpdpg tegekpgelm pssgaktvll kvpedaenpt esekpdtsae sdteqnperk
     1861 veedgaeese fkiqivprqr kqrkiavsai qreyldisfn ildklgeqkd pdpstkglst
     1921 lempresssa ptldagvpet sshssistqy rqmkrgslgv ltmsqlmkrq lehqssaphn
     1981 isnwdteqiq pgkrqcnvpt clnpdlegqp lrmrgatkss llsapsivsm fvpapeeftd
     2041 eqptvmtdkc hdcgaileey deetlglaiv vlstfihlsp dlaapllldi mqsvgrlass
     2101 ttfsnqaesm mvpgnaagva kqflrcifhq lapngifpql fqstikdgtf lrtlasslmd
     2161 fnelssiaal sqlleglnnk knlpaggami rcleniatfm ealpmdspss lwttisnqfq
     2221 tffaklpcvl plkcsldssl rimicllkip stnatrslle pfskllsfvi qnavftlayl
     2281 velcglcyra ftkerdkfyl srsvvlellq alklksplpd tnllllvqfi cadagtklae
     2341 stilskqmia svpgcgtaam ecvrqyinev ldfmadmhtl tklkshmktc sqplhedtfg
     2401 ghlkvglaqi aamdisrgnh rdnkaviryl pwlyhppsam qqgpkefiec vshirllswl
     2461 llgslthnav cpnasspclp ipldagshva dhliviligf peqsktsvlh mcslfhafif
     2521 aqlwtvyceq savatnlqnq nefsftailt alefwsrvtp silqlmahnk vmvemvclhv
     2581 islmealqec nstifvklip mwlpmiqsni khlsaglqlr lqaiqnhvnh hslrtlpgsg
     2641 qssaglaalr kwlqctqfkm aqveiqssea asqfypl
//
LOCUS       XP_047287580            2673 aa            linear   PRI 05-AUG-2025
DEFINITION  protein unc-79 homolog isoform X15 [Homo sapiens].
ACCESSION   XP_047287580
VERSION     XP_047287580.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431624.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2673
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2673
                     /product="protein unc-79 homolog isoform X15"
                     /calculated_mol_wt=299169
     Region          114..645
                     /region_name="UNC-79"
                     /note="Cation-channel complex subunit UNC-79; pfam14776"
                     /db_xref="CDD:434201"
     CDS             1..2673
                     /gene="UNC79"
                     /gene_synonym="KIAA1409"
                     /coded_by="XM_047431624.1:92..8113"
                     /db_xref="GeneID:57578"
                     /db_xref="HGNC:HGNC:19966"
                     /db_xref="MIM:616884"
ORIGIN      
        1 mstkaeqfas kirylqeyhn rvlhniypvp sgtdiantlk yfsqtllsil srtgkkenqd
       61 asnltvpmtm clfpvpfplt pslrpqvssi nptvtrslly svlrdapser gpqsrdaqls
      121 dypsldyqgl yvtlvtlldl vpllqhgqhd lgqsifyttt cllpflnddi lstlpytmis
      181 tlatfppflh kdiieylsts flpmailgss rregvpahvn lsassmlmia mqytsnpvyh
      241 cqlleclmky kqevwkdlly viaygpsqvk ppavqmlfhy wpnlkppgai seyrglqyta
      301 wnpihcqhie chnainkpav kmcidpslsv algdkppply lceecseria gdhsewlidv
      361 llpqaeisai cqkkncsshv rravvtcfsa gccgrhgnrp vryckrchsn hhsnevgaaa
      421 ethlyqtspp pintrecgae elvcaveavi sllkeaefha eqrehelnrr rqlglssshh
      481 sldnadfdnk dddkhdqrll sqfgiwflvs lctpsentpt eslarlvamv fqwfhstaym
      541 mddevgslve klkpqfvtkw lktvcdvrfd vmvmcllpkp mefarvggyw dkscstvtql
      601 keglnrilcl ipynvinqsv wecimpewle airtevpdnq lkefrevlsk mfdielcplp
      661 fsmeemfgfi scrftgypss vqeqallwlh vlseldimvp lqllismfsd gvnsvkelan
      721 qrksrvsela gnlasrrvsv asdpgrrvqh nmlspfhspf qspfrsplrs pfrspfknfg
      781 hpggrtidfd ceddemnlnc filmfdlllk qmelqddgit mglehslskd iisiinnvfq
      841 apwggshtcq kdekaiecnl cqssilcyql acellerlap keesrlvept dsledsllss
      901 rpefiigpeg eeeenpaskh genpgnctep vehaavkndt erkfcyqqlp vtlrliytif
      961 qemakfeepd ilfnmlnclk ilclhgecly iarkdhpqfl ayiqdhmlia slwrvvksef
     1021 sqlsslavpl llhalslphg adifwtiing nfnskdwkmr feavekvavi crfldihsvt
     1081 knhllkysla hafccfltav edvnpavatr agllldtikr palqglclcl dfqfdtvvkd
     1141 rptilsklll lhflkqdipa lsweffvnrf etlsleaqlh ldcnkefpfp ttitavrtnv
     1201 anlsdaalwk ikrarfarnr qksvrslrds vkgpveskra lslpetltsk ipmrltrheq
     1261 sapalggtpe qtpgqqspen dntikdllpe dagidhqtvh qlitvlmkfm akdessaesd
     1321 issakafntv krhlyvllgy dqqegcfmia pqkmrlstcf nafiagiaqp prcslwslkp
     1381 hirqmwlkal lvilykypyr dcdiskillh lihitvntln aqyhsckpha tagplysdns
     1441 nisrysekek eedsvfdesd ihdtptgpcn kesqtffarl kriggskmvk yqpvemnvqr
     1501 seielaeyre tgalqdsllh cvreesipkk klrsfkqksl dignadsllf tldehrrksc
     1561 idrcdiekpp tqaayiaqrp ndpgrsrqns atrpdnseip enpamegfpd arrpvipevr
     1621 lncmetfevk vdspvkpapk edldlidlss dstsgpekhs ilstsdsdsl vfeplpplri
     1681 vesdeeeetm nqgddgpsgk naasspsvps hpsvlslsta plvqvsvedc skdfsskdsg
     1741 nnqsagntds alitledpmd aegsskpeel pefscgsplt lkqkrdllqk sfalpemsld
     1801 dhpdpgtege kpgelmpssg aktvllkvpe daenptesek pdtsaesdte qnperkveed
     1861 gaeesefkiq ivprqrkqrk iavsaiqrey ldisfnildk lgeqkdpdps tkglstlemp
     1921 resssaptld agvpetsshs sistqyrqmk rgslgvltms qlmkrqlehq ssaphnisnw
     1981 dteqiqpgkr qcnvptclnp dlegqplrmr gatkssllsa psivsmfvpa peeftdeqpt
     2041 vmtdkchdcg aileeydeet lglaivvlst fihlspdlaa pllldimqsv grlassttfs
     2101 nqaesmmvpg naagvakqfl rcifhqlapn gifpqlfqst ikdgtflrtl asslmdfnel
     2161 ssiaalsqll eglnnkknlp aggamircle niatfmealp mdspsslwtt isnqfqtffa
     2221 klpcvlplkc sldsslrimi cllkipstna trsllepfsk llsfviqnav ftlaylvelc
     2281 glcyraftke rdkfylsrsv vlellqalkl ksplpdtnll llvqficada gtklaestil
     2341 skqmiasvpg cgtaamecvr qyinevldfm admhtltklk shmktcsqpl hedtfgghlk
     2401 vglaqiaamd isrgnhrdnk avirylpwly hppsamqqgp kefiecvshi rllswlllgs
     2461 lthnavcpna sspclpipld agshvadhli viligfpeqs ktsvlhmcsl fhafifaqlw
     2521 tvyceqsava tnlqnqnefs ftailtalef wsrvtpsilq lmahnkvmve mvclhvislm
     2581 ealqecnsti fvklipmwlp miqsnikhls aglqlrlqai qnhvnhhslr tlpgsgqssa
     2641 glaalrkwlq ctqfkmaqve iqsseaasqf ypl
//
LOCUS       XP_011535327            2669 aa            linear   PRI 05-AUG-2025
DEFINITION  protein unc-79 homolog isoform X16 [Homo sapiens].
ACCESSION   XP_011535327
VERSION     XP_011535327.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537025.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2669
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2669
                     /product="protein unc-79 homolog isoform X16"
                     /calculated_mol_wt=299140
     Region          159..690
                     /region_name="UNC-79"
                     /note="Cation-channel complex subunit UNC-79; pfam14776"
                     /db_xref="CDD:434201"
     CDS             1..2669
                     /gene="UNC79"
                     /gene_synonym="KIAA1409"
                     /coded_by="XM_011537025.3:3540..11549"
                     /db_xref="GeneID:57578"
                     /db_xref="HGNC:HGNC:19966"
                     /db_xref="MIM:616884"
ORIGIN      
        1 mdsvensvee etretliima pwdlqrgmtr tgsfttarsk vrsgmwtmlv tpvaskiryl
       61 qeyhnrvlhn iypvpsgtdi antlkyfsqt llsilsrtgk kenqdasnlt vpmtmclfpv
      121 pfpltpslrp qvssinptvt rsllysvlrd apsergpqsr daqlsdypsl dyqglyvtlv
      181 tlldlvpllq hgqhdlgqsi fytttcllpf lnddilstlp ytmistlatf ppflhkdiie
      241 ylstsflpma ilgssrregv pahvnlsass mlmiamqyts npvyhcqlle clmkykqevw
      301 kdllyviayg psqvkppavq mlfhywpnlk ppgaiseyrg lqytawnpih cqhiechnai
      361 nkpavkmcid pslsvalgdk ppplylceec seriagdhse wlidvllpqa eisaicqkkn
      421 csshvrravv tcfsagccgr hgnrpvryck rchsnhhsne vgaaaethly qtspppintr
      481 ecgaeelvca veavisllke aefhaeqreh elnrrrqlgl ssshhsldna dfdnkdddkh
      541 dqrllsqfgi wflvslctps entpteslar lvamvfqwfh staymmddev gslveklkpq
      601 fvtkwlktvc dvrfdvmvmc llpkpmefar vggywdkscs tvtqlkegln rilclipynv
      661 inqsvwecim pewleairte vpdnqlkefr evlskmfdie lcplpfsmee mfgfiscrft
      721 gypssvqeqa llwlhvlsel dimvplqlli smfsdgvnsv kelanqrksr vselagnlas
      781 rrvsvasdpg rrvqhnmlsp fhspfqspfr splrspfrsp fknfghpggr tidfdcedde
      841 mnlncfilmf dlllkqmelq ddgitmgleh slskdiisii nnvfqapwgg shtcqkdeka
      901 iecnlcqssi lcyqlacell erlapkeesr lveptdsled sllssrpefi igpegeeeen
      961 paskhgenpg nctepvehaa vkndterkfc yqqlpvtlrl iytifqemak feepdilfnm
     1021 lnclkilclh geclyiarkd hpqflayiqd hmliaslwrv vksefsqlss lavplllhal
     1081 slphgadifw tiingnfnsk dwkmrfeave kvavicrfld ihsvtknhll kyslahafcc
     1141 fltavedvnp avatraglll dtikrpalqg lclcldfqfd tvvkdrptil skllllhflk
     1201 qdipalswef fvnrfetlsl eaqlhldcnk efpfpttita vrtnvanlsd aalwkikrar
     1261 farnrqksvr slrdsvkgpv eskralslpe tltskipmrl trheqsapal ggtpeqtpgq
     1321 qspendntik dllpedagid hqtvhqlitv lmkfmakdes saesdissak afntvkrhly
     1381 vllgydqqeg cfmiapqkmr lstcfnafia giaqvmdyni nlgkhllplv vqvlkycscp
     1441 qlrhyfqqpp rcslwslkph irqmwlkall vilykypyrd cdiskillhl ihitvntlna
     1501 qyhsckphat agplysdnsn isrysekeke edsvfdesdi hdtptgpcnk esqtffarlk
     1561 riggskmvky qpvemnvqrs eielaeyret galqdsllhc vreesipkkk lrsfkqksld
     1621 ignadsllft ldehrrksci drcdiekppt qaayiaqrpn dpgrsrqnsa trpdnseipe
     1681 npamegfpda rrpvipevrl ncmetfevkv dspvkpapke dldlidlssd stsgpekhsi
     1741 lstsdsdslv feplpplriv esdeeeetmn qgddgpsgkn aasspsvpsh psvlslstap
     1801 lvqvsvedcs kdfsskdsgn nqsagntdsa litledpmda egsskpeelp efscgspltl
     1861 kqkrdllqks falpemsldd hpdpgtegek pgelmpssga ktvllkvped aenptesekp
     1921 dtsaesdteq nperkveedg aeesefkiqi vprqrkqrki avsaiqreyl disfnildkl
     1981 geqkdpdpst kglstlempr esssaptlda gvpetsshss istqyrqmkr gslgvltmsq
     2041 lmkrqlehqs saphnisnwd teqiqpgkrq cnvptclnpd legqplrmrg atkssllsap
     2101 sivsmfvpap eeftdeqptv mtdkchdcga ileeydeetl glaivvlstf ihlspdlaap
     2161 llldimqsvg rlassttfsn qaesmmvpgn aagvakqflr cifhqlapng ifpqlfqsti
     2221 kdgtflrtla sslmdfnels siaalsqlle glnnkknlpa ggamirclen iatfmealpm
     2281 dspsslwtti snqfqtffak lpcvlplkcs ldsslrimic llkipstnat rsllepfskl
     2341 lsfviqnavf tlaylvelcg lcyraftker dkfylsrsvv lellqalklk splpdtnlll
     2401 lvqficadag tklaestils kqmiasvpgc gtaamecvrq yinevldfma dmhtltklks
     2461 hmktcsqplh edtfgghlkv glaqiaamdi srgnhrdnka virylpwlyh ppsamqqgpk
     2521 efiecvshir llswlllgsl thnavcpnas spclpiplda gshvadhliv iligfpeqsk
     2581 tsvlhmcslf hafifaqlwt vyceqsavat nlqnqnefsf tailtalefw srvtpsilql
     2641 mahnkvisvv rlykwigdml pykldvlla
//
LOCUS       XP_016877003            2663 aa            linear   PRI 05-AUG-2025
DEFINITION  protein unc-79 homolog isoform X17 [Homo sapiens].
ACCESSION   XP_016877003
VERSION     XP_016877003.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021514.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2663
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2663
                     /product="protein unc-79 homolog isoform X17"
                     /calculated_mol_wt=298005
     Region          159..690
                     /region_name="UNC-79"
                     /note="Cation-channel complex subunit UNC-79; pfam14776"
                     /db_xref="CDD:434201"
     CDS             1..2663
                     /gene="UNC79"
                     /gene_synonym="KIAA1409"
                     /coded_by="XM_017021514.2:3540..11531"
                     /db_xref="GeneID:57578"
                     /db_xref="HGNC:HGNC:19966"
                     /db_xref="MIM:616884"
ORIGIN      
        1 mdsvensvee etretliima pwdlqrgmtr tgsfttarsk vrsgmwtmlv tpvaskiryl
       61 qeyhnrvlhn iypvpsgtdi antlkyfsqt llsilsrtgk kenqdasnlt vpmtmclfpv
      121 pfpltpslrp qvssinptvt rsllysvlrd apsergpqsr daqlsdypsl dyqglyvtlv
      181 tlldlvpllq hgqhdlgqsi fytttcllpf lnddilstlp ytmistlatf ppflhkdiie
      241 ylstsflpma ilgssrregv pahvnlsass mlmiamqyts npvyhcqlle clmkykqevw
      301 kdllyviayg psqvkppavq mlfhywpnlk ppgaiseyrg lqytawnpih cqhiechnai
      361 nkpavkmcid pslsvalgdk ppplylceec seriagdhse wlidvllpqa eisaicqkkn
      421 csshvrravv tcfsagccgr hgnrpvryck rchsnhhsne vgaaaethly qtspppintr
      481 ecgaeelvca veavisllke aefhaeqreh elnrrrqlgl ssshhsldna dfdnkdddkh
      541 dqrllsqfgi wflvslctps entpteslar lvamvfqwfh staymmddev gslveklkpq
      601 fvtkwlktvc dvrfdvmvmc llpkpmefar vggywdkscs tvtqlkegln rilclipynv
      661 inqsvwecim pewleairte vpdnqlkefr evlskmfdie lcplpfsmee mfgfiscrft
      721 gypssvqeqa llwlhvlsel dimvplqlli smfsdgvnsv kelanqrksr vselagnlas
      781 rrvsvasdpg rrvqhnmlsp fhspfqspfr splrspfrsp fknfghpggr tidfdcedde
      841 mnlncfilmf dlllkqmelq ddgitmgleh slskdiisii nnvfqapwgg shtcqkdeka
      901 iecnlcqssi lcyqlacell erlapkeesr lveptdsled sllssrpefi igpegeeeen
      961 paskhgenpg nctepvehaa vkndterkfc yqqlpvtlrl iytifqemak feepdilfnm
     1021 lnclkilclh geclyiarkd hpqflayiqd hmliaslwrv vksefsqlss lavplllhal
     1081 slphgadifw tiingnfnsk dwkmrfeave kvavicrfld ihsvtknhll kyslahafcc
     1141 fltavedvnp avatraglll dtikrpalqg lclcldfqfd tvvkdrptil skllllhflk
     1201 qdipalswef fvnrfetlsl eaqlhldcnk efpfpttita vrtnvanlsd aalwkikrar
     1261 farnrqksvr slrdsvkgpv eskralslpe tltskipmrl trheqsapal ggtpeqtpgq
     1321 qspendntik dllpedagid hqtvhqlitv lmkfmakdes saesdissak afntvkrhly
     1381 vllgydqqeg cfmiapqkmr lstcfnafia giaqvmdyni nlgkhllplv vqvlkycscp
     1441 qlrhyfqqpp rcslwslkph irqmwlkall vilykypyrd cdiskillhl ihitvntlna
     1501 qyhsckphat agplysdnsn isrysekekg eielaeyret galqdsllhc vreesipkkk
     1561 lrsfkqksld ignadsllft ldehrrksci drcdiekppt qaayiaqrpn dpgrsrqnsa
     1621 trpdnseipe npamegfpda rrpvipevrl ncmetfevkv dspvkpapke dldlidlssd
     1681 stsgpekhsi lstsdsdslv feplpplriv esdeeeetmn qgddgpsgkn aasspsvpsh
     1741 psvlslstap lvqvsvedcs kdfsskdsgn nqsagntdsa litledpmda egsskpeelp
     1801 efscgspltl kqkrdllqks falpemsldd hpdpgtegek pgelmpssga ktvllkvped
     1861 aenptesekp dtsaesdteq nperkveedg aeesefkiqi vprqrkqrki avsaiqreyl
     1921 disfnildkl geqkdpdpst kglstlempr esssaptlda gvpetsshss iskqiqpgkr
     1981 qcnvptclnp dlegqplrmr gatkssllsa psivsmfvpa peeftdeqpt vmtdkchdcg
     2041 aileeydeet lglaivvlst fihlspdlaa pllldimqsv grlassttfs nqaesmmvpg
     2101 naagvakqfl rcifhqlapn gifpqlfqst ikdgtflrtl asslmdfnel ssiaalsqll
     2161 eglnnkknlp aggamircle niatfmealp mdspsslwtt isnqfqtffa klpcvlplkc
     2221 sldsslrimi cllkipstna trsllepfsk llsfviqnav ftlaylvelc glcyraftke
     2281 rdkfylsrsv vlellqalkl ksplpdtnll llvqficada gtklaestil skqmiasvpg
     2341 cgtaamecvr qyinevldfm admhtltklk shmktcsqpl hedtfgghlk vglaqiaamd
     2401 isrgnhrdnk avirylpwly hppsamqqgp kefiecvshi rllswlllgs lthnavcpna
     2461 sspclpipld agshvadhli viligfpeqs ktsvlhmcsl fhafifaqlw tvyceqsava
     2521 tnlqnqnefs ftailtalef wsrvtpsilq lmahnkvmve mvclhvislm ealqecnsti
     2581 fvklipmwlp miqsnikhls aglqlrlqai qnhvnhhslr tlpgsgqssa glaalrkwlq
     2641 ctqfkmaqve iqsseaasqf ypl
//
LOCUS       XP_016877004            2654 aa            linear   PRI 05-AUG-2025
DEFINITION  protein unc-79 homolog isoform X18 [Homo sapiens].
ACCESSION   XP_016877004
VERSION     XP_016877004.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021515.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2654
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2654
                     /product="protein unc-79 homolog isoform X18"
                     /calculated_mol_wt=297383
     Region          61..592
                     /region_name="UNC-79"
                     /note="Cation-channel complex subunit UNC-79; pfam14776"
                     /db_xref="CDD:434201"
     CDS             1..2654
                     /gene="UNC79"
                     /gene_synonym="KIAA1409"
                     /coded_by="XM_017021515.2:92..8056"
                     /db_xref="GeneID:57578"
                     /db_xref="HGNC:HGNC:19966"
                     /db_xref="MIM:616884"
ORIGIN      
        1 mstkaeqfas kirylqeyhn rvlhniypvp sgtdiantlk yfsqtllsvl rdapsergpq
       61 srdaqlsdyp sldyqglyvt lvtlldlvpl lqhgqhdlgq sifytttcll pflnddilst
      121 lpytmistla tfppflhkdi ieylstsflp mailgssrre gvpahvnlsa ssmlmiamqy
      181 tsnpvyhcql leclmkykqe vwkdllyvia ygpsqvkppa vqmlfhywpn lkppgaisey
      241 rglqytawnp ihcqhiechn ainkpavkmc idpslsvalg dkppplylce ecseriagdh
      301 sewlidvllp qaeisaicqk kncsshvrra vvtcfsagcc grhgnrpvry ckrchsnhhs
      361 nevgaaaeth lyqtspppin trecgaeelv caveavisll keaefhaeqr ehelnrrrql
      421 glssshhsld nadfdnkddd khdqrllsqf giwflvslct psentptesl arlvamvfqw
      481 fhstaymmdd evgslveklk pqfvtkwlkt vcdvrfdvmv mcllpkpmef arvggywdks
      541 cstvtqlkeg lnrilclipy nvinqsvwec impewleair tevpdnqlke frevlskmfd
      601 ielcplpfsm eemfgfiscr ftgypssvqe qallwlhvls eldimvplql lismfsdgvn
      661 svkelanqrk srvselagnl asrrvsvasd pgrrvqhnml spfhspfqsp frsplrspfr
      721 spfknfghpg grtidfdced demnlncfil mfdlllkqme lqddgitmgl ehslskdiis
      781 iinnvfqapw ggshtcqkde kaiecnlcqs silcyqlace llerlapkee srlveptdsl
      841 edsllssrpe fiigpegeee enpaskhgen pgnctepveh aavkndterk fcyqqlpvtl
      901 rliytifqem akfeepdilf nmlnclkilc lhgeclyiar kdhpqflayi qdhmliaslw
      961 rvvksefsql sslavplllh alslphgadi fwtiingnfn skdwkmrfea vekvavicrf
     1021 ldihsvtknh llkyslahaf ccfltavedv npavatragl lldtikrpal qglclcldfq
     1081 fdtvvkdrpt ilskllllhf lkqdipalsw effvnrfetl sleaqlhldc nkefpfptti
     1141 tavrtnvanl sdaalwkikr arfarnrqks vrslrdsvkg pveskralsl petltskipm
     1201 rltrheqsap alggtpeqtp gqqspendnt ikdllpedag idhqtvhqli tvlmkfmakd
     1261 essaesdiss akafntvkrh lyvllgydqq egcfmiapqk mrlstcfnaf iagiaqvmdy
     1321 ninlgkhllp lvvqvlkycs cpqlrhyfqq pprcslwslk phirqmwlka llvilykypy
     1381 rdcdiskill hlihitvntl naqyhsckph atagplysdn snisryseke keedsvfdes
     1441 dihdtptgpc nkesqtffar lkriggskmv kyqpvemnvq rseielaeyr etgalqdsll
     1501 hcvreesipk kklrsfkqks ldignadsll ftldehrrks cidrcdiekp ptqaayiaqr
     1561 pndpgrsrqn satrpdnsei penpamegfp darrpvipev rlncmetfev kvdspvkpap
     1621 kedldlidls sdstsgpekh silstsdsds lvfeplpplr ivesdeeeet mnqgddgpsg
     1681 knaasspsvp shpsvlslst aplvqvsved cskdfsskds gnnqsagntd salitledpm
     1741 daegsskpee lpefscgspl tlkqkrdllq ksfalpemsl ddhpdpgteg ekpgelmpss
     1801 gaktvllkvp edaenptese kpdtsaesdt eqnperkvee dgaeesefki qivprqrkqr
     1861 kiavsaiqre yldisfnild klgeqkdpdp stkglstlem presssaptl dagvpetssh
     1921 ssistqyrqm krgslgvltm sqlmkrqleh qssaphnisn wdteqiqpgk rqcnvptcln
     1981 pdlegqplrm rgatksslls apsivsmfvp apeeftdeqp tvmtdkchdc gaileeydee
     2041 tlglaivvls tfihlspdla apllldimqs vgrlassttf snqaesmmvp gnaagvakqf
     2101 lrcifhqlap ngifpqlfqs tikdgtflrt lasslmdfne lssiaalsql leglnnkknl
     2161 paggamircl eniatfmeal pmdspsslwt tisnqfqtff aklpcvlplk csldsslrim
     2221 icllkipstn atrsllepfs kllsfviqna vftlaylvel cglcyraftk erdkfylsrs
     2281 vvlellqalk lksplpdtnl lllvqficad agtklaesti lskqmiasvp gcgtaamecv
     2341 rqyinevldf madmhtltkl kshmktcsqp lhedtfgghl kvglaqiaam disrgnhrdn
     2401 kavirylpwl yhppsamqqg pkefiecvsh irllswlllg slthnavcpn asspclpipl
     2461 dagshvadhl iviligfpeq sktsvlhmcs lfhafifaql wtvyceqsav atnlqnqnef
     2521 sftailtale fwsrvtpsil qlmahnkvmv emvclhvisl mealqecnst ifvklipmwl
     2581 pmiqsnikhl saglqlrlqa iqnhvnhhsl rtlpgsgqss aglaalrkwl qctqfkmaqv
     2641 eiqsseaasq fypl
//
LOCUS       XP_047287581            2647 aa            linear   PRI 05-AUG-2025
DEFINITION  protein unc-79 homolog isoform X19 [Homo sapiens].
ACCESSION   XP_047287581
VERSION     XP_047287581.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431625.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2647
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2647
                     /product="protein unc-79 homolog isoform X19"
                     /calculated_mol_wt=296571
     Region          106..637
                     /region_name="UNC-79"
                     /note="Cation-channel complex subunit UNC-79; pfam14776"
                     /db_xref="CDD:434201"
     CDS             1..2647
                     /gene="UNC79"
                     /gene_synonym="KIAA1409"
                     /coded_by="XM_047431625.1:3540..11483"
                     /db_xref="GeneID:57578"
                     /db_xref="HGNC:HGNC:19966"
                     /db_xref="MIM:616884"
ORIGIN      
        1 mdsvensvee etretliima pwdlqrgmtr tgsfttarsk vrsgmwtmlv tpvaskiryl
       61 qeyhnrvlhn iypvpsgtdi antlkyfsqt llsvlrdaps ergpqsrdaq lsdypsldyq
      121 glyvtlvtll dlvpllqhgq hdlgqsifyt ttcllpflnd dilstlpytm istlatfppf
      181 lhkdiieyls tsflpmailg ssrregvpah vnlsassmlm iamqytsnpv yhcqlleclm
      241 kykqevwkdl lyviaygpsq vkppavqmlf hywpnlkppg aiseyrglqy tawnpihcqh
      301 iechnainkp avkmcidpsl svalgdkppp lylceecser iagdhsewli dvllpqaeis
      361 aicqkkncss hvrravvtcf sagccgrhgn rpvryckrch snhhsnevga aaethlyqts
      421 pppintrecg aeelvcavea visllkeaef haeqreheln rrrqlglsss hhsldnadfd
      481 nkdddkhdqr llsqfgiwfl vslctpsent pteslarlva mvfqwfhsta ymmddevgsl
      541 veklkpqfvt kwlktvcdvr fdvmvmcllp kpmefarvgg ywdkscstvt qlkeglnril
      601 clipynvinq svwecimpew leairtevpd nqlkefrevl skmfdielcp lpfsmeemfg
      661 fiscrftgyp ssvqeqallw lhvlseldim vplqllismf sdgvnsvkel anqrksrvse
      721 lagnlasrrv svasdpgrrv qhnmlspfhs pfqspfrspl rspfrspfkn fghpggrtid
      781 fdceddemnl ncfilmfdll lkqmelqddg itmglehsls kdiisiinnv fqapwggsht
      841 cqkdekaiec nlcqssilcy qlacellerl apkeesrlve ptdsledsll ssrpefiigp
      901 egeeeenpas khgenpgnct epvehaavkn dterkfcyqq lpvtlrliyt ifqemakfee
      961 pdilfnmlnc lkilclhgec lyiarkdhpq flayiqdhml iaslwrvvks efsqlsslav
     1021 plllhalslp hgadifwtii ngnfnskdwk mrfeavekva vicrfldihs vtknhllkys
     1081 lahafccflt avedvnpava tragllldti krpalqglcl cldfqfdtvv kdrptilskl
     1141 lllhflkqdi palsweffvn rfetlsleaq lhldcnkefp fpttitavrt nvanlsdaal
     1201 wkikrarfar nrqksvrslr dsvkgpvesk ralslpetlt skipmrltrh eqsapalggt
     1261 peqtpgqqsp endntikdll pedagidhqt vhqlitvlmk fmakdessae sdissakafn
     1321 tvkrhlyvll gydqqegcfm iapqkmrlst cfnafiagia qvmdyninlg khllplvvqv
     1381 lkycscpqlr hyfqqpprcs lwslkphirq mwlkallvil ykypyrdcdi skillhlihi
     1441 tvntlnaqyh sckphatagp lysdnsnisr ysekekeeds vfdesdihdt ptgpcnkesq
     1501 tffarlkrig gskmvkyqpv emnvqrnehr rkscidrcdi ekpptqaayi aqrpndpgrs
     1561 rqnsatrpdn seipenpame gfpdarrpvi pevrlncmet fevkvdspvk papkedldli
     1621 dlssdstsgp ekhsilstsd sdslvfeplp plrivesdee eetmnqgddg psgknaassp
     1681 svpshpsvls lstaplvqvs vedcskdfss kdsgnnqsag ntdsalitle dpmdaegssk
     1741 peelpefscg spltlkqkrd llqksfalpe mslddhpdpg tegekpgelm pssgaktvll
     1801 kvpedaenpt esekpdtsae sdteqnperk veedgaeese fkiqivprqr kqrkiavsai
     1861 qreyldisfn ildklgeqkd pdpstkglst lempresssa ptldagvpet sshssistqy
     1921 rqmkrgslgv ltmsqlmkrq lehqssaphn isnwdteqiq pgkrqcnvpt clnpdlegqp
     1981 lrmrgatkss llsapsivsm fvpapeeftd eqptvmtdkc hdcgaileey deetlglaiv
     2041 vlstfihlsp dlaapllldi mqsvgrlass ttfsnqaesm mvpgnaagva kqflrcifhq
     2101 lapngifpql fqstikdgtf lrtlasslmd fnelssiaal sqlleglnnk knlpaggami
     2161 rcleniatfm ealpmdspss lwttisnqfq tffaklpcvl plkcsldssl rimicllkip
     2221 stnatrslle pfskllsfvi qnavftlayl velcglcyra ftkerdkfyl srsvvlellq
     2281 alklksplpd tnllllvqfi cadagtklae stilskqmia svpgcgtaam ecvrqyinev
     2341 ldfmadmhtl tklkshmktc sqplhedtfg ghlkvglaqi aamdisrgnh rdnkaviryl
     2401 pwlyhppsam qqgpkefiec vshirllswl llgslthnav cpnasspclp ipldagshva
     2461 dhliviligf peqsktsvlh mcslfhafif aqlwtvyceq savatnlqnq nefsftailt
     2521 alefwsrvtp silqlmahnk vmvemvclhv islmealqec nstifvklip mwlpmiqsni
     2581 khlsaglqlr lqaiqnhvnh hslrtlpgsg qssaglaalr kwlqctqfkm aqveiqssea
     2641 asqfypl
//
LOCUS       XP_024305436            2645 aa            linear   PRI 05-AUG-2025
DEFINITION  protein unc-79 homolog isoform X20 [Homo sapiens].
ACCESSION   XP_024305436
VERSION     XP_024305436.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449668.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2645
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2645
                     /product="protein unc-79 homolog isoform X20"
                     /calculated_mol_wt=295884
     Region          114..583
                     /region_name="UNC-79"
                     /note="Cation-channel complex subunit UNC-79; pfam14776"
                     /db_xref="CDD:434201"
     CDS             1..2645
                     /gene="UNC79"
                     /gene_synonym="KIAA1409"
                     /coded_by="XM_024449668.2:92..8029"
                     /db_xref="GeneID:57578"
                     /db_xref="HGNC:HGNC:19966"
                     /db_xref="MIM:616884"
ORIGIN      
        1 mstkaeqfas kirylqeyhn rvlhniypvp sgtdiantlk yfsqtllsil srtgkkenqd
       61 asnltvpmtm clfpvpfplt pslrpqvssi nptvtrslly svlrdapser gpqsrdaqls
      121 dypsldyqgl yvtlvtlldl vpllqhgqhd lgqsifyttt cllpflnddi lstlpytmis
      181 tlatfppflh kdiieylsts flpmailgss rregvpahvn lsassmlmia mqytsnpawn
      241 pihcqhiech nainkpavkm cidpslsval gdkppplylc eecseriagd hsewlidvll
      301 pqaeisaicq kkncsshvrr avvtcfsagc cgrhgnrpvr yckrchsnhh snevgaaaet
      361 hlyqtspppi ntrecgaeel vcaveavisl lkeaefhaeq rehelnrrrq lglssshhsl
      421 dnadfdnkdd dkhdqrllsq fgiwflvslc tpsentptes larlvamvfq wfhstaymmd
      481 devgslvekl kpqfvtkwlk tvcdvrfdvm vmcllpkpme farvggywdk scstvtqlke
      541 glnrilclip ynvinqsvwe cimpewleai rtevpdnqlk efrevlskmf dielcplpfs
      601 meemfgfisc rftgypssvq eqallwlhvl seldimvplq llismfsdgv nsvkelanqr
      661 ksrvselagn lasrrvsvas dpgrrvqhnm lspfhspfqs pfrsplrspf rspfknfghp
      721 ggrtidfdce ddemnlncfi lmfdlllkqm elqddgitmg lehslskdii siinnvfqap
      781 wggshtcqkd ekaiecnlcq ssilcyqlac ellerlapke esrlveptds ledsllssrp
      841 efiigpegee eenpaskhge npgnctepve haavkndter kfcyqqlpvt lrliytifqe
      901 makfeepdil fnmlnclkil clhgeclyia rkdhpqflay iqdhmliasl wrvvksefsq
      961 lsslavplll halslphgad ifwtiingnf nskdwkmrfe avekvavicr fldihsvtkn
     1021 hllkyslaha fccfltaved vnpavatrag llldtikrpa lqglclcldf qfdtvvkdrp
     1081 tilskllllh flkqdipals weffvnrfet lsleaqlhld cnkefpfptt itavrtnvan
     1141 lsdaalwkik rarfarnrqk svrslrdsvk gpveskrals lpetltskip mrltrheqsa
     1201 palggtpeqt pgqqspendn tikdllpeda gidhqtvhql itvlmkfmak dessaesdis
     1261 sakafntvkr hlyvllgydq qegcfmiapq kmrlstcfna fiagiaqvmd yninlgkhll
     1321 plvvqvlkyc scpqlrhyfq qpprcslwsl kphirqmwlk allvilykyp yrdcdiskil
     1381 lhlihitvnt lnaqyhsckp hatagplysd nsnisrysek ekeedsvfde sdihdtptgp
     1441 cnkesqtffa rlkriggskm vkyqpvemnv qrseielaey retgalqdsl lhcvreesip
     1501 kkklrsfkqk sldignadsl lftldehrrk scidrcdiek pptqaayiaq rpndpgrsrq
     1561 nsatrpdnse ipenpamegf pdarrpvipe vrlncmetfe vkvdspvkpa pkedldlidl
     1621 ssdstsgpek hsilstsdsd slvfeplppl rivesdeeee tmnqgddgps gknaasspsv
     1681 pshpsvlsls taplvqvsve dcskdfsskd sgnnqsagnt dsalitledp mdaegsskpe
     1741 elpefscgsp ltlkqkrdll qksfalpems lddhpdpgte gekpgelmps sgaktvllkv
     1801 pedaenptes ekpdtsaesd teqnperkve edgaeesefk iqivprqrkq rkiavsaiqr
     1861 eyldisfnil dklgeqkdpd pstkglstle mpresssapt ldagvpetss hssistqyrq
     1921 mkrgslgvlt msqlmkrqle hqssaphnis nwdteqiqpg krqcnvptcl npdlegqplr
     1981 mrgatkssll sapsivsmfv papeeftdeq ptvmtdkchd cgaileeyde etlglaivvl
     2041 stfihlspdl aapllldimq svgrlasstt fsnqaesmmv pgnaagvakq flrcifhqla
     2101 pngifpqlfq stikdgtflr tlasslmdfn elssiaalsq lleglnnkkn lpaggamirc
     2161 leniatfmea lpmdspsslw ttisnqfqtf faklpcvlpl kcsldsslri micllkipst
     2221 natrsllepf skllsfviqn avftlaylve lcglcyraft kerdkfylsr svvlellqal
     2281 klksplpdtn llllvqfica dagtklaest ilskqmiasv pgcgtaamec vrqyinevld
     2341 fmadmhtltk lkshmktcsq plhedtfggh lkvglaqiaa mdisrgnhrd nkavirylpw
     2401 lyhppsamqq gpkefiecvs hirllswlll gslthnavcp nasspclpip ldagshvadh
     2461 liviligfpe qsktsvlhmc slfhafifaq lwtvyceqsa vatnlqnqne fsftailtal
     2521 efwsrvtpsi lqlmahnkvm vemvclhvis lmealqecns tifvklipmw lpmiqsnikh
     2581 lsaglqlrlq aiqnhvnhhs lrtlpgsgqs saglaalrkw lqctqfkmaq veiqsseaas
     2641 qfypl
//
LOCUS       XP_016877005            2641 aa            linear   PRI 05-AUG-2025
DEFINITION  protein unc-79 homolog isoform X21 [Homo sapiens].
ACCESSION   XP_016877005
VERSION     XP_016877005.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021516.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2641
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2641
                     /product="protein unc-79 homolog isoform X21"
                     /calculated_mol_wt=295748
     Region          159..690
                     /region_name="UNC-79"
                     /note="Cation-channel complex subunit UNC-79; pfam14776"
                     /db_xref="CDD:434201"
     CDS             1..2641
                     /gene="UNC79"
                     /gene_synonym="KIAA1409"
                     /coded_by="XM_017021516.2:3540..11465"
                     /db_xref="GeneID:57578"
                     /db_xref="HGNC:HGNC:19966"
                     /db_xref="MIM:616884"
ORIGIN      
        1 mdsvensvee etretliima pwdlqrgmtr tgsfttarsk vrsgmwtmlv tpvaskiryl
       61 qeyhnrvlhn iypvpsgtdi antlkyfsqt llsilsrtgk kenqdasnlt vpmtmclfpv
      121 pfpltpslrp qvssinptvt rsllysvlrd apsergpqsr daqlsdypsl dyqglyvtlv
      181 tlldlvpllq hgqhdlgqsi fytttcllpf lnddilstlp ytmistlatf ppflhkdiie
      241 ylstsflpma ilgssrregv pahvnlsass mlmiamqyts npvyhcqlle clmkykqevw
      301 kdllyviayg psqvkppavq mlfhywpnlk ppgaiseyrg lqytawnpih cqhiechnai
      361 nkpavkmcid pslsvalgdk ppplylceec seriagdhse wlidvllpqa eisaicqkkn
      421 csshvrravv tcfsagccgr hgnrpvryck rchsnhhsne vgaaaethly qtspppintr
      481 ecgaeelvca veavisllke aefhaeqreh elnrrrqlgl ssshhsldna dfdnkdddkh
      541 dqrllsqfgi wflvslctps entpteslar lvamvfqwfh staymmddev gslveklkpq
      601 fvtkwlktvc dvrfdvmvmc llpkpmefar vggywdkscs tvtqlkegln rilclipynv
      661 inqsvwecim pewleairte vpdnqlkefr evlskmfdie lcplpfsmee mfgfiscrft
      721 gypssvqeqa llwlhvlsel dimvplqlli smfsdgvnsv kelanqrksr vselagnlas
      781 rrvsvasdpg rrvqhnmlsp fhspfqspfr splrspfrsp fknfghpggr tidfdcedde
      841 mnlncfilmf dlllkqmelq ddgitmgleh slskdiisii nnvfqapwgg shtcqkdeka
      901 iecnlcqssi lcyqlacell erlapkeesr lveptdsled sllssrpefi igpegeeeen
      961 paskhgenpg nctepvehaa vkndterkfc yqqlpvtlrl iytifqemak feepdilfnm
     1021 lnclkilclh geclyiarkd hpqflayiqd hmliaslwrv vksefsqlss lavplllhal
     1081 slphgadifw tiingnfnsk dwkmrfeave kvavicrfld ihsvtknhll kyslahafcc
     1141 fltavedvnp avatraglll dtikrpalqg lclcldfqfd tvvkdrptil skllllhflk
     1201 qdipalswef fvnrfetlsl eaqlhldcnk efpfpttita vrtnvanlsd aalwkikrar
     1261 farnrqksvr slrdsvkgpv eskralslpe tltskirqqs pendntikdl lpedagidhq
     1321 tvhqlitvlm kfmakdessa esdissakaf ntvkrhlyvl lgydqqegcf miapqkmrls
     1381 tcfnafiagi aqvmdyninl gkhllplvvq vlkycscpql rhyfqqpprc slwslkphir
     1441 qmwlkallvi lykypyrdcd iskillhlih itvntlnaqy hsckphatag plysdnsnis
     1501 rysekekgei elaeyretga lqdsllhcvr eesipkkklr sfkqksldig nadsllftld
     1561 ehrrkscidr cdiekpptqa ayiaqrpndp grsrqnsatr pdnseipenp amegfpdarr
     1621 pvipevrlnc metfevkvds pvkpapkedl dlidlssdst sgpekhsils tsdsdslvfe
     1681 plpplrives deeeetmnqg ddgpsgknaa sspsvpshps vlslstaplv qvsvedcskd
     1741 fsskdsgnnq sagntdsali tledpmdaeg sskpeelpef scgspltlkq krdllqksfa
     1801 lpemslddhp dpgtegekpg elmpssgakt vllkvpedae nptesekpdt saesdteqnp
     1861 erkveedgae esefkiqivp rqrkqrkiav saiqreyldi sfnildklge qkdpdpstkg
     1921 lstlempres ssaptldagv petsshssis kqiqpgkrqc nvptclnpdl egqplrmrga
     1981 tkssllsaps ivsmfvpape eftdeqptvm tdkchdcgai leeydeetlg laivvlstfi
     2041 hlspdlaapl lldimqsvgr lassttfsnq aesmmvpgna agvakqflrc ifhqlapngi
     2101 fpqlfqstik dgtflrtlas slmdfnelss iaalsqlleg lnnkknlpag gamircleni
     2161 atfmealpmd spsslwttis nqfqtffakl pcvlplkcsl dsslrimicl lkipstnatr
     2221 sllepfskll sfviqnavft laylvelcgl cyraftkerd kfylsrsvvl ellqalklks
     2281 plpdtnllll vqficadagt klaestilsk qmiasvpgcg taamecvrqy inevldfmad
     2341 mhtltklksh mktcsqplhe dtfgghlkvg laqiaamdis rgnhrdnkav irylpwlyhp
     2401 psamqqgpke fiecvshirl lswlllgslt hnavcpnass pclpipldag shvadhlivi
     2461 ligfpeqskt svlhmcslfh afifaqlwtv yceqsavatn lqnqnefsft ailtalefws
     2521 rvtpsilqlm ahnkvmvemv clhvislmea lqecnstifv klipmwlpmi qsnikhlsag
     2581 lqlrlqaiqn hvnhhslrtl pgsgqssagl aalrkwlqct qfkmaqveiq sseaasqfyp
     2641 l
//
LOCUS       XP_011535328            2640 aa            linear   PRI 05-AUG-2025
DEFINITION  protein unc-79 homolog isoform X22 [Homo sapiens].
ACCESSION   XP_011535328
VERSION     XP_011535328.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537026.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2640
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2640
                     /product="protein unc-79 homolog isoform X22"
                     /calculated_mol_wt=295602
     Region          47..578
                     /region_name="UNC-79"
                     /note="Cation-channel complex subunit UNC-79; pfam14776"
                     /db_xref="CDD:434201"
     CDS             1..2640
                     /gene="UNC79"
                     /gene_synonym="KIAA1409"
                     /coded_by="XM_011537026.3:319..8241"
                     /db_xref="GeneID:57578"
                     /db_xref="HGNC:HGNC:19966"
                     /db_xref="MIM:616884"
ORIGIN      
        1 mtmclfpvpf pltpslrpqv ssinptvtrs llysvlrdap sergpqsrda qlsdypsldy
       61 qglyvtlvtl ldlvpllqhg qhdlgqsify tttcllpfln ddilstlpyt mistlatfpp
      121 flhkdiieyl stsflpmail gssrregvpa hvnlsassml miamqytsnp vyhcqllecl
      181 mkykqevwkd llyviaygps qvkppavqml fhywpnlkpp gaiseyrglq ytawnpihcq
      241 hiechnaink pavkmcidps lsvalgdkpp plylceecse riagdhsewl idvllpqaei
      301 saicqkkncs shvrravvtc fsagccgrhg nrpvryckrc hsnhhsnevg aaaethlyqt
      361 spppintrec gaeelvcave avisllkeae fhaeqrehel nrrrqlglss shhsldnadf
      421 dnkdddkhdq rllsqfgiwf lvslctpsen tpteslarlv amvfqwfhst aymmddevgs
      481 lveklkpqfv tkwlktvcdv rfdvmvmcll pkpmefarvg gywdkscstv tqlkeglnri
      541 lclipynvin qsvwecimpe wleairtevp dnqlkefrev lskmfdielc plpfsmeemf
      601 gfiscrftgy pssvqeqall wlhvlseldi mvplqllism fsdgvnsvke lanqrksrvs
      661 elagnlasrr vsvasdpgrr vqhnmlspfh spfqspfrsp lrspfrspfk nfghpggrti
      721 dfdceddemn lncfilmfdl llkqmelqdd gitmglehsl skdiisiinn vfqapwggsh
      781 tcqkdekaie cnlcqssilc yqlaceller lapkeesrlv eptdsledsl lssrpefiig
      841 pegeeeenpa skhgenpgnc tepvehaavk ndterkfcyq qlpvtlrliy tifqemakfe
      901 epdilfnmln clkilclhge clyiarkdhp qflayiqdhm liaslwrvvk sefsqlssla
      961 vplllhalsl phgadifwti ingnfnskdw kmrfeavekv avicrfldih svtknhllky
     1021 slahafccfl tavedvnpav atragllldt ikrpalqglc lcldfqfdtv vkdrptilsk
     1081 llllhflkqd ipalsweffv nrfetlslea qlhldcnkef pfpttitavr tnvanlsdaa
     1141 lwkikrarfa rnrqksvrsl rdsvkgpves kralslpetl tskipmrltr heqsapalgg
     1201 tpeqtpgqqs pendntikdl lpedagidhq tvhqlitvlm kfmakdessa esdissakaf
     1261 ntvkrhlyvl lgydqqegcf miapqkmrls tcfnafiagi aqvmdyninl gkhllplvvq
     1321 vlkycscpql rhyfqqpprc slwslkphir qmwlkallvi lykypyrdcd iskillhlih
     1381 itvntlnaqy hsckphatag plysdnsnis rysekekeed svfdesdihd tptgpcnkes
     1441 qtffarlkri ggskmvkyqp vemnvqrsei elaeyretga lqdsllhcvr eesipkkklr
     1501 sfkqksldig nadsllftld ehrrkscidr cdiekpptqa ayiaqrpndp grsrqnsatr
     1561 pdnseipenp amegfpdarr pvipevrlnc metfevkvds pvkpapkedl dlidlssdst
     1621 sgpekhsils tsdsdslvfe plpplrives deeeetmnqg ddgpsgknaa sspsvpshps
     1681 vlslstaplv qvsvedcskd fsskdsgnnq sagntdsali tledpmdaeg sskpeelpef
     1741 scgspltlkq krdllqksfa lpemslddhp dpgtegekpg elmpssgakt vllkvpedae
     1801 nptesekpdt saesdteqnp erkveedgae esefkiqivp rqrkqrkiav saiqreyldi
     1861 sfnildklge qkdpdpstkg lstlempres ssaptldagv petsshssis tqyrqmkrgs
     1921 lgvltmsqlm krqlehqssa phnisnwdte qiqpgkrqcn vptclnpdle gqplrmrgat
     1981 kssllsapsi vsmfvpapee ftdeqptvmt dkchdcgail eeydeetlgl aivvlstfih
     2041 lspdlaapll ldimqsvgrl assttfsnqa esmmvpgnaa gvakqflrci fhqlapngif
     2101 pqlfqstikd gtflrtlass lmdfnelssi aalsqllegl nnkknlpagg amirclenia
     2161 tfmealpmds psslwttisn qfqtffaklp cvlplkcsld sslrimicll kipstnatrs
     2221 llepfsklls fviqnavftl aylvelcglc yraftkerdk fylsrsvvle llqalklksp
     2281 lpdtnllllv qficadagtk laestilskq miasvpgcgt aamecvrqyi nevldfmadm
     2341 htltklkshm ktcsqplhed tfgghlkvgl aqiaamdisr gnhrdnkavi rylpwlyhpp
     2401 samqqgpkef iecvshirll swlllgslth navcpnassp clpipldags hvadhlivil
     2461 igfpeqskts vlhmcslfha fifaqlwtvy ceqsavatnl qnqnefsfta iltalefwsr
     2521 vtpsilqlma hnkvmvemvc lhvislmeal qecnstifvk lipmwlpmiq snikhlsagl
     2581 qlrlqaiqnh vnhhslrtlp gsgqssagla alrkwlqctq fkmaqveiqs seaasqfypl
//
LOCUS       XP_011535329            2640 aa            linear   PRI 05-AUG-2025
DEFINITION  protein unc-79 homolog isoform X22 [Homo sapiens].
ACCESSION   XP_011535329
VERSION     XP_011535329.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537027.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2640
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2640
                     /product="protein unc-79 homolog isoform X22"
                     /calculated_mol_wt=295602
     Region          47..578
                     /region_name="UNC-79"
                     /note="Cation-channel complex subunit UNC-79; pfam14776"
                     /db_xref="CDD:434201"
     CDS             1..2640
                     /gene="UNC79"
                     /gene_synonym="KIAA1409"
                     /coded_by="XM_011537027.3:522..8444"
                     /db_xref="GeneID:57578"
                     /db_xref="HGNC:HGNC:19966"
                     /db_xref="MIM:616884"
ORIGIN      
        1 mtmclfpvpf pltpslrpqv ssinptvtrs llysvlrdap sergpqsrda qlsdypsldy
       61 qglyvtlvtl ldlvpllqhg qhdlgqsify tttcllpfln ddilstlpyt mistlatfpp
      121 flhkdiieyl stsflpmail gssrregvpa hvnlsassml miamqytsnp vyhcqllecl
      181 mkykqevwkd llyviaygps qvkppavqml fhywpnlkpp gaiseyrglq ytawnpihcq
      241 hiechnaink pavkmcidps lsvalgdkpp plylceecse riagdhsewl idvllpqaei
      301 saicqkkncs shvrravvtc fsagccgrhg nrpvryckrc hsnhhsnevg aaaethlyqt
      361 spppintrec gaeelvcave avisllkeae fhaeqrehel nrrrqlglss shhsldnadf
      421 dnkdddkhdq rllsqfgiwf lvslctpsen tpteslarlv amvfqwfhst aymmddevgs
      481 lveklkpqfv tkwlktvcdv rfdvmvmcll pkpmefarvg gywdkscstv tqlkeglnri
      541 lclipynvin qsvwecimpe wleairtevp dnqlkefrev lskmfdielc plpfsmeemf
      601 gfiscrftgy pssvqeqall wlhvlseldi mvplqllism fsdgvnsvke lanqrksrvs
      661 elagnlasrr vsvasdpgrr vqhnmlspfh spfqspfrsp lrspfrspfk nfghpggrti
      721 dfdceddemn lncfilmfdl llkqmelqdd gitmglehsl skdiisiinn vfqapwggsh
      781 tcqkdekaie cnlcqssilc yqlaceller lapkeesrlv eptdsledsl lssrpefiig
      841 pegeeeenpa skhgenpgnc tepvehaavk ndterkfcyq qlpvtlrliy tifqemakfe
      901 epdilfnmln clkilclhge clyiarkdhp qflayiqdhm liaslwrvvk sefsqlssla
      961 vplllhalsl phgadifwti ingnfnskdw kmrfeavekv avicrfldih svtknhllky
     1021 slahafccfl tavedvnpav atragllldt ikrpalqglc lcldfqfdtv vkdrptilsk
     1081 llllhflkqd ipalsweffv nrfetlslea qlhldcnkef pfpttitavr tnvanlsdaa
     1141 lwkikrarfa rnrqksvrsl rdsvkgpves kralslpetl tskipmrltr heqsapalgg
     1201 tpeqtpgqqs pendntikdl lpedagidhq tvhqlitvlm kfmakdessa esdissakaf
     1261 ntvkrhlyvl lgydqqegcf miapqkmrls tcfnafiagi aqvmdyninl gkhllplvvq
     1321 vlkycscpql rhyfqqpprc slwslkphir qmwlkallvi lykypyrdcd iskillhlih
     1381 itvntlnaqy hsckphatag plysdnsnis rysekekeed svfdesdihd tptgpcnkes
     1441 qtffarlkri ggskmvkyqp vemnvqrsei elaeyretga lqdsllhcvr eesipkkklr
     1501 sfkqksldig nadsllftld ehrrkscidr cdiekpptqa ayiaqrpndp grsrqnsatr
     1561 pdnseipenp amegfpdarr pvipevrlnc metfevkvds pvkpapkedl dlidlssdst
     1621 sgpekhsils tsdsdslvfe plpplrives deeeetmnqg ddgpsgknaa sspsvpshps
     1681 vlslstaplv qvsvedcskd fsskdsgnnq sagntdsali tledpmdaeg sskpeelpef
     1741 scgspltlkq krdllqksfa lpemslddhp dpgtegekpg elmpssgakt vllkvpedae
     1801 nptesekpdt saesdteqnp erkveedgae esefkiqivp rqrkqrkiav saiqreyldi
     1861 sfnildklge qkdpdpstkg lstlempres ssaptldagv petsshssis tqyrqmkrgs
     1921 lgvltmsqlm krqlehqssa phnisnwdte qiqpgkrqcn vptclnpdle gqplrmrgat
     1981 kssllsapsi vsmfvpapee ftdeqptvmt dkchdcgail eeydeetlgl aivvlstfih
     2041 lspdlaapll ldimqsvgrl assttfsnqa esmmvpgnaa gvakqflrci fhqlapngif
     2101 pqlfqstikd gtflrtlass lmdfnelssi aalsqllegl nnkknlpagg amirclenia
     2161 tfmealpmds psslwttisn qfqtffaklp cvlplkcsld sslrimicll kipstnatrs
     2221 llepfsklls fviqnavftl aylvelcglc yraftkerdk fylsrsvvle llqalklksp
     2281 lpdtnllllv qficadagtk laestilskq miasvpgcgt aamecvrqyi nevldfmadm
     2341 htltklkshm ktcsqplhed tfgghlkvgl aqiaamdisr gnhrdnkavi rylpwlyhpp
     2401 samqqgpkef iecvshirll swlllgslth navcpnassp clpipldags hvadhlivil
     2461 igfpeqskts vlhmcslfha fifaqlwtvy ceqsavatnl qnqnefsfta iltalefwsr
     2521 vtpsilqlma hnkvmvemvc lhvislmeal qecnstifvk lipmwlpmiq snikhlsagl
     2581 qlrlqaiqnh vnhhslrtlp gsgqssagla alrkwlqctq fkmaqveiqs seaasqfypl
//
LOCUS       XP_047287582            2624 aa            linear   PRI 05-AUG-2025
DEFINITION  protein unc-79 homolog isoform X23 [Homo sapiens].
ACCESSION   XP_047287582
VERSION     XP_047287582.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431626.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2624
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2624
                     /product="protein unc-79 homolog isoform X23"
                     /calculated_mol_wt=294410
     Region          106..584
                     /region_name="UNC-79"
                     /note="Cation-channel complex subunit UNC-79; pfam14776"
                     /db_xref="CDD:434201"
     CDS             1..2624
                     /gene="UNC79"
                     /gene_synonym="KIAA1409"
                     /coded_by="XM_047431626.1:3540..11414"
                     /db_xref="GeneID:57578"
                     /db_xref="HGNC:HGNC:19966"
                     /db_xref="MIM:616884"
ORIGIN      
        1 mdsvensvee etretliima pwdlqrgmtr tgsfttarsk vrsgmwtmlv tpvaskiryl
       61 qeyhnrvlhn iypvpsgtdi antlkyfsqt llsvlrdaps ergpqsrdaq lsdypsldyq
      121 glyvtlvtll dlvpllqhgq hdlgqsifyt ttcllpflnd dilstlpytm istlatfppf
      181 lhkdiieyls tsflpmailg ssrregvpah vnlsassmlm iamqytsnpv yhcqlleclm
      241 kykqevwkdl lyviaygpsq vkppavqmlf hywpnlkppg aiseyrglqy tawnpihcqh
      301 iechnainkp avkncsshvr ravvtcfsag ccgrhgnrpv ryckrchsnh hsnevgaaae
      361 thlyqtsppp intrecgaee lvcaveavis llkeaefhae qrehelnrrr qlglssshhs
      421 ldnadfdnkd ddkhdqrlls qfgiwflvsl ctpsentpte slarlvamvf qwfhstaymm
      481 ddevgslvek lkpqfvtkwl ktvcdvrfdv mvmcllpkpm efarvggywd kscstvtqlk
      541 eglnrilcli pynvinqsvw ecimpewlea irtevpdnql kefrevlskm fdielcplpf
      601 smeemfgfis crftgypssv qeqallwlhv lseldimvpl qllismfsdg vnsvkelanq
      661 rksrvselag nlasrrvsva sdpgrrvqhn mlspfhspfq spfrsplrsp frspfknfgh
      721 pggrtidfdc eddemnlncf ilmfdlllkq melqddgitm glehslskdi isiinnvfqa
      781 pwggshtcqk dekaiecnlc qssilcyqla cellerlapk eesrlveptd sledsllssr
      841 pefiigpege eeenpaskhg enpgnctepv ehaavkndte rkfcyqqlpv tlrliytifq
      901 emakfeepdi lfnmlnclki lclhgeclyi arkdhpqfla yiqdhmlias lwrvvksefs
      961 qlsslavpll lhalslphga difwtiingn fnskdwkmrf eavekvavic rfldihsvtk
     1021 nhllkyslah afccfltave dvnpavatra gllldtikrp alqglclcld fqfdtvvkdr
     1081 ptilskllll hflkqdipal sweffvnrfe tlsleaqlhl dcnkefpfpt titavrtnva
     1141 nlsdaalwki krarfarnrq ksvrslrdsv kgpveskral slpetltski rqqspendnt
     1201 ikdllpedag idhqtvhqli tvlmkfmakd essaesdiss akafntvkrh lyvllgydqq
     1261 egcfmiapqk mrlstcfnaf iagiaqvmdy ninlgkhllp lvvqvlkycs cpqlrhyfqq
     1321 pprcslwslk phirqmwlka llvilykypy rdcdiskill hlihitvntl naqyhsckph
     1381 atagplysdn snisryseke keedsvfdes dihdtptgpc nkesqtffar lkriggskmv
     1441 kyqpvemnvq rseielaeyr etgalqdsll hcvreesipk kklrsfkqks ldignadsll
     1501 ftldehrrks cidrcdiekp ptqaayiaqr pndpgrsrqn satrpdnsei penpamegfp
     1561 darrpvipev rlncmetfev kvdspvkpap kedldlidls sdstsgpekh silstsdsds
     1621 lvfeplpplr ivesdeeeet mnqgddgpsg knaasspsvp shpsvlslst aplvqvsved
     1681 cskdfsskds gnnqsagntd salitledpm daegsskpee lpefscgspl tlkqkrdllq
     1741 ksfalpemsl ddhpdpgteg ekpgelmpss gaktvllkvp edaenptese kpdtsaesdt
     1801 eqnperkvee dgaeesefki qivprqrkqr kiavsaiqre yldisfnild klgeqkdpdp
     1861 stkglstlem presssaptl dagvpetssh ssistqyrqm krgslgvltm sqlmkrqleh
     1921 qssaphnisn wdteqiqpgk rqcnvptcln pdlegqplrm rgatksslls apsivsmfvp
     1981 apeeftdeqp tvmtdkchdc gaileeydee tlglaivvls tfihlspdla apllldimqs
     2041 vgrlassttf snqaesmmvp gnaagvakqf lrcifhqlap ngifpqlfqs tikdgtflrt
     2101 lasslmdfne lssiaalsql leglnnkknl paggamircl eniatfmeal pmdspsslwt
     2161 tisnqfqtff aklpcvlplk csldsslrim icllkipstn atrsllepfs kllsfviqna
     2221 vftlaylvel cglcyraftk erdkfylsrs vvlellqalk lksplpdtnl lllvqficad
     2281 agtklaesti lskqmiasvp gcgtaamecv rqyinevldf madmhtltkl kshmktcsqp
     2341 lhedtfgghl kvglaqiaam disrgnhrdn kavirylpwl yhppsamqqg pkefiecvsh
     2401 irllswlllg slthnavcpn asspclpipl dagshvadhl iviligfpeq sktsvlhmcs
     2461 lfhafifaql wtvyceqsav atnlqnqnef sftailtale fwsrvtpsil qlmahnkvmv
     2521 emvclhvisl mealqecnst ifvklipmwl pmiqsnikhl saglqlrlqa iqnhvnhhsl
     2581 rtlpgsgqss aglaalrkwl qctqfkmaqv eiqsseaasq fypl
//
LOCUS       XP_047287583            2601 aa            linear   PRI 05-AUG-2025
DEFINITION  protein unc-79 homolog isoform X24 [Homo sapiens].
ACCESSION   XP_047287583
VERSION     XP_047287583.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431627.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2601
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2601
                     /product="protein unc-79 homolog isoform X24"
                     /calculated_mol_wt=291574
     Region          61..539
                     /region_name="UNC-79"
                     /note="Cation-channel complex subunit UNC-79; pfam14776"
                     /db_xref="CDD:434201"
     CDS             1..2601
                     /gene="UNC79"
                     /gene_synonym="KIAA1409"
                     /coded_by="XM_047431627.1:92..7897"
                     /db_xref="GeneID:57578"
                     /db_xref="HGNC:HGNC:19966"
                     /db_xref="MIM:616884"
ORIGIN      
        1 mstkaeqfas kirylqeyhn rvlhniypvp sgtdiantlk yfsqtllsvl rdapsergpq
       61 srdaqlsdyp sldyqglyvt lvtlldlvpl lqhgqhdlgq sifytttcll pflnddilst
      121 lpytmistla tfppflhkdi ieylstsflp mailgssrre gvpahvnlsa ssmlmiamqy
      181 tsnpvyhcql leclmkykqe vwkdllyvia ygpsqvkppa vqmlfhywpn lkppgaisey
      241 rglqytawnp ihcqhiechn ainkpavknc sshvrravvt cfsagccgrh gnrpvryckr
      301 chsnhhsnev gaaaethlyq tspppintre cgaeelvcav eavisllkea efhaeqrehe
      361 lnrrrqlgls sshhsldnad fdnkdddkhd qrllsqfgiw flvslctpse ntpteslarl
      421 vamvfqwfhs taymmddevg slveklkpqf vtkwlktvcd vrfdvmvmcl lpkpmefarv
      481 ggywdkscst vtqlkeglnr ilclipynvi nqsvwecimp ewleairtev pdnqlkefre
      541 vlskmfdiel cplpfsmeem fgfiscrftg ypssvqeqal lwlhvlseld imvplqllis
      601 mfsdgvnsvk elanqrksrv selagnlasr rvsvasdpgr rvqhnmlspf hspfqspfrs
      661 plrspfrspf knfghpggrt idfdceddem nlncfilmfd lllkqmelqd dgitmglehs
      721 lskdiisiin nvfqapwggs htcqkdekai ecnlcqssil cyqlacelle rlapkeesrl
      781 veptdsleds llssrpefii gpegeeeenp askhgenpgn ctepvehaav kndterkfcy
      841 qqlpvtlrli ytifqemakf eepdilfnml nclkilclhg eclyiarkdh pqflayiqdh
      901 mliaslwrvv ksefsqlssl avplllhals lphgadifwt iingnfnskd wkmrfeavek
      961 vavicrfldi hsvtknhllk yslahafccf ltavedvnpa vatragllld tikrpalqgl
     1021 clcldfqfdt vvkdrptils kllllhflkq dipalsweff vnrfetlsle aqlhldcnke
     1081 fpfpttitav rtnvanlsda alwkikrarf arnrqksvrs lrdsvkgpve skralslpet
     1141 ltskipmrlt rheqsapalg gtpeqtpgqq spendntikd llpedagidh qtvhqlitvl
     1201 mkfmakdess aesdissaka fntvkrhlyv llgydqqegc fmiapqkmrl stcfnafiag
     1261 iaqvmdynin lgkhllplvv qvlkycscpq lrhyfqqppr cslwslkphi rqmwlkallv
     1321 ilykypyrdc diskillhli hitvntlnaq yhsckphata gplysdnsni srysekekee
     1381 dsvfdesdih dtptgpcnke sqtffarlkr iggskmvkyq pvemnvqrse ielaeyretg
     1441 alqdsllhcv reesipkkkl rsfkqksldi gnadsllftl dehrrkscid rcdiekpptq
     1501 aayiaqrpnd pgrsrqnsat rpdnseipen pamegfpdar rpvipevrln cmetfevkvd
     1561 spvkpapked ldlidlssds tsgpekhsil stsdsdslvf eplpplrive sdeeeetmnq
     1621 gddgpsgkna asspsvpshp svlslstapl vqvsvedcsk dfsskdsgnn qsagntdsal
     1681 itledpmdae gsskpeelpe fscgspltlk qkrdllqksf alpemslddh pdpgtegekp
     1741 gelmpssgak tvllkvpeda enptesekpd tsaesdteqn perkveedga eesefkiqiv
     1801 prqrkqrkia vsaiqreyld isfnildklg eqkdpdpstk glstlempre sssaptldag
     1861 vpetsshssi stqyrqmkrg slgvltmsql mkrqlehqss aphnisnwdt eqiqpgkrqc
     1921 nvptclnpdl egqplrmrga tkssllsaps ivsmfvpape eftdeqptvm tdkchdcgai
     1981 leeydeetlg laivvlstfi hlspdlaapl lldimqsvgr lassttfsnq aesmmvpgna
     2041 agvakqflrc ifhqlapngi fpqlfqstik dgtflrtlas slmdfnelss iaalsqlleg
     2101 lnnkknlpag gamircleni atfmealpmd spsslwttis nqfqtffakl pcvlplkcsl
     2161 dsslrimicl lkipstnatr sllepfskll sfviqnavft laylvelcgl cyraftkerd
     2221 kfylsrsvvl ellqalklks plpdtnllll vqficadagt klaestilsk qmiasvpgcg
     2281 taamecvrqy inevldfmad mhtltklksh mktcsqplhe dtfgghlkvg laqiaamdis
     2341 rgnhrdnkav irylpwlyhp psamqqgpke fiecvshirl lswlllgslt hnavcpnass
     2401 pclpipldag shvadhlivi ligfpeqskt svlhmcslfh afifaqlwtv yceqsavatn
     2461 lqnqnefsft ailtalefws rvtpsilqlm ahnkvmvemv clhvislmea lqecnstifv
     2521 klipmwlpmi qsnikhlsag lqlrlqaiqn hvnhhslrtl pgsgqssagl aalrkwlqct
     2581 qfkmaqveiq sseaasqfyp l
//
LOCUS       XP_016877006            2588 aa            linear   PRI 05-AUG-2025
DEFINITION  protein unc-79 homolog isoform X25 [Homo sapiens].
ACCESSION   XP_016877006
VERSION     XP_016877006.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021517.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2588
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2588
                     /product="protein unc-79 homolog isoform X25"
                     /calculated_mol_wt=289918
     Region          106..637
                     /region_name="UNC-79"
                     /note="Cation-channel complex subunit UNC-79; pfam14776"
                     /db_xref="CDD:434201"
     CDS             1..2588
                     /gene="UNC79"
                     /gene_synonym="KIAA1409"
                     /coded_by="XM_017021517.2:3540..11306"
                     /db_xref="GeneID:57578"
                     /db_xref="HGNC:HGNC:19966"
                     /db_xref="MIM:616884"
ORIGIN      
        1 mdsvensvee etretliima pwdlqrgmtr tgsfttarsk vrsgmwtmlv tpvaskiryl
       61 qeyhnrvlhn iypvpsgtdi antlkyfsqt llsvlrdaps ergpqsrdaq lsdypsldyq
      121 glyvtlvtll dlvpllqhgq hdlgqsifyt ttcllpflnd dilstlpytm istlatfppf
      181 lhkdiieyls tsflpmailg ssrregvpah vnlsassmlm iamqytsnpv yhcqlleclm
      241 kykqevwkdl lyviaygpsq vkppavqmlf hywpnlkppg aiseyrglqy tawnpihcqh
      301 iechnainkp avkmcidpsl svalgdkppp lylceecser iagdhsewli dvllpqaeis
      361 aicqkkncss hvrravvtcf sagccgrhgn rpvryckrch snhhsnevga aaethlyqts
      421 pppintrecg aeelvcavea visllkeaef haeqreheln rrrqlglsss hhsldnadfd
      481 nkdddkhdqr llsqfgiwfl vslctpsent pteslarlva mvfqwfhsta ymmddevgsl
      541 veklkpqfvt kwlktvcdvr fdvmvmcllp kpmefarvgg ywdkscstvt qlkeglnril
      601 clipynvinq svwecimpew leairtevpd nqlkefrevl skmfdielcp lpfsmeemfg
      661 fiscrftgyp ssvqeqallw lhvlseldim vplqllismf sdgvnsvkel anqrksrvse
      721 lagnlasrrv svasdpgrrv qhnmlspfhs pfqspfrspl rspfrspfkn fghpggrtid
      781 fdceddemnl ncfilmfdll lkqmelqddg itmglehsls kdiisiinnv fqapwggsht
      841 cqkdekaiec nlcqssilcy qlacellerl apkeesrlve ptdsledsll ssrpefiigp
      901 egeeeenpas khgenpgnct epvehaavkn dterkfcyqq lpvtlrliyt ifqemakfee
      961 pdilfnmlnc lkilclhgec lyiarkdhpq flayiqdhml iaslwrvvks efsqlsslav
     1021 plllhalslp hgadifwtii ngnfnskdwk mrfeavekva vicrfldihs vtknhllkys
     1081 lahafccflt avedvnpava tragllldti krpalqglcl cldfqfdtvv kdrptilskl
     1141 lllhflkqdi palsweffvn rfetlsleaq lhldcnkefp fpttitavrt nvanlsdaal
     1201 wkikrarfar nrqksvrslr dsvkgpvesk ralslpetlt skirqqspen dntikdllpe
     1261 dagidhqtvh qlitvlmkfm akdessaesd issakafntv krhlyvllgy dqqegcfmia
     1321 pqkmrlstcf nafiagiaqv mdyninlgkh llplvvqvlk ycscpqlrhy fqqpprcslw
     1381 slkphirqmw lkallvilyk ypyrdcdisk illhlihitv ntlnaqyhsc kphatagply
     1441 sdnsnisrys ekekgeiela eyretgalqd sllhcvrees ipkkklrsfk qksldignad
     1501 sllftldehr rkscidrcdi ekpptqaayi aqrpndpgrs rqnsatrpdn seipenpame
     1561 gfpdarrpvi pevrlncmet fevkvdspvk papkedldli dlssdstsgp ekhsilstsd
     1621 sdslvfeplp plrivesdee eetmnqgddg psgknaassp svpshpsvls lstaplvqvs
     1681 vedcskdfss kdsgnnqsag ntdsalitle dpmdaegssk peelpefscg spltlkqkrd
     1741 llqksfalpe mslddhpdpg tegekpgelm pssgaktvll kvpedaenpt esekpdtsae
     1801 sdteqnperk veedgaeese fkiqivprqr kqrkiavsai qreyldisfn ildklgeqkd
     1861 pdpstkglst lempresssa ptldagvpet sshssiskqi qpgkrqcnvp tclnpdlegq
     1921 plrmrgatks sllsapsivs mfvpapeeft deqptvmtdk chdcgailee ydeetlglai
     1981 vvlstfihls pdlaapllld imqsvgrlas sttfsnqaes mmvpgnaagv akqflrcifh
     2041 qlapngifpq lfqstikdgt flrtlasslm dfnelssiaa lsqlleglnn kknlpaggam
     2101 ircleniatf mealpmdsps slwttisnqf qtffaklpcv lplkcsldss lrimicllki
     2161 pstnatrsll epfskllsfv iqnavftlay lvelcglcyr aftkerdkfy lsrsvvlell
     2221 qalklksplp dtnllllvqf icadagtkla estilskqmi asvpgcgtaa mecvrqyine
     2281 vldfmadmht ltklkshmkt csqplhedtf gghlkvglaq iaamdisrgn hrdnkaviry
     2341 lpwlyhppsa mqqgpkefie cvshirllsw lllgslthna vcpnasspcl pipldagshv
     2401 adhlivilig fpeqsktsvl hmcslfhafi faqlwtvyce qsavatnlqn qnefsftail
     2461 talefwsrvt psilqlmahn kvmvemvclh vislmealqe cnstifvkli pmwlpmiqsn
     2521 ikhlsaglql rlqaiqnhvn hhslrtlpgs gqssaglaal rkwlqctqfk maqveiqsse
     2581 aasqfypl
//
LOCUS       XP_016877007            2386 aa            linear   PRI 05-AUG-2025
DEFINITION  protein unc-79 homolog isoform X26 [Homo sapiens].
ACCESSION   XP_016877007
VERSION     XP_016877007.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021518.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2386
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2386
                     /product="protein unc-79 homolog isoform X26"
                     /calculated_mol_wt=266918
     Region          <1..324
                     /region_name="UNC-79"
                     /note="Cation-channel complex subunit UNC-79; pfam14776"
                     /db_xref="CDD:434201"
     CDS             1..2386
                     /gene="UNC79"
                     /gene_synonym="KIAA1409"
                     /coded_by="XM_017021518.2:2880..10040"
                     /db_xref="GeneID:57578"
                     /db_xref="HGNC:HGNC:19966"
                     /db_xref="MIM:616884"
ORIGIN      
        1 mcidpslsva lgdkppplyl ceecseriag dhsewlidvl lpqaeisaic qkkncsshvr
       61 ravvtcfsag ccgrhgnrpv ryckrchsnh hsnevgaaae thlyqtsppp intrecgaee
      121 lvcaveavis llkeaefhae qrehelnrrr qlglssshhs ldnadfdnkd ddkhdqrlls
      181 qfgiwflvsl ctpsentpte slarlvamvf qwfhstaymm ddevgslvek lkpqfvtkwl
      241 ktvcdvrfdv mvmcllpkpm efarvggywd kscstvtqlk eglnrilcli pynvinqsvw
      301 ecimpewlea irtevpdnql kefrevlskm fdielcplpf smeemfgfis crftgypssv
      361 qeqallwlhv lseldimvpl qllismfsdg vnsvkelanq rksrvselag nlasrrvsva
      421 sdpgrrvqhn mlspfhspfq spfrsplrsp frspfknfgh pggrtidfdc eddemnlncf
      481 ilmfdlllkq melqddgitm glehslskdi isiinnvfqa pwggshtcqk dekaiecnlc
      541 qssilcyqla cellerlapk eesrlveptd sledsllssr pefiigpege eeenpaskhg
      601 enpgnctepv ehaavkndte rkfcyqqlpv tlrliytifq emakfeepdi lfnmlnclki
      661 lclhgeclyi arkdhpqfla yiqdhmlias lwrvvksefs qlsslavpll lhalslphga
      721 difwtiingn fnskdwkmrf eavekvavic rfldihsvtk nhllkyslah afccfltave
      781 dvnpavatra gllldtikrp alqglclcld fqfdtvvkdr ptilskllll hflkqdipal
      841 sweffvnrfe tlsleaqlhl dcnkefpfpt titavrtnva nlsdaalwki krarfarnrq
      901 ksvrslrdsv kgpveskral slpetltski pmrltrheqs apalggtpeq tpgqqspend
      961 ntikdllped agidhqtvhq litvlmkfma kdessaesdi ssakafntvk rhlyvllgyd
     1021 qqegcfmiap qkmrlstcfn afiagiaqvm dyninlgkhl lplvvqvlky cscpqlrhyf
     1081 qqpprcslws lkphirqmwl kallvilyky pyrdcdiski llhlihitvn tlnaqyhsck
     1141 phatagplys dnsnisryse kekeedsvfd esdihdtptg pcnkesqtff arlkriggsk
     1201 mvkyqpvemn vqrseielae yretgalqds llhcvreesi pkkklrsfkq ksldignads
     1261 llftldehrr kscidrcdie kpptqaayia qrpndpgrsr qnsatrpdns eipenpameg
     1321 fpdarrpvip evrlncmetf evkvdspvkp apkedldlid lssdstsgpe khsilstsds
     1381 dslvfeplpp lrivesdeee etmnqgddgp sgknaassps vpshpsvlsl staplvqvsv
     1441 edcskdfssk dsgnnqsagn tdsalitled pmdaegsskp eelpefscgs pltlkqkrdl
     1501 lqksfalpem slddhpdpgt egekpgelmp ssgaktvllk vpedaenpte sekpdtsaes
     1561 dteqnperkv eedgaeesef kiqivprqrk qrkiavsaiq reyldisfni ldklgeqkdp
     1621 dpstkglstl empresssap tldagvpets shssistqyr qmkrgslgvl tmsqlmkrql
     1681 ehqssaphni snwdteqiqp gkrqcnvptc lnpdlegqpl rmrgatkssl lsapsivsmf
     1741 vpapeeftde qptvmtdkch dcgaileeyd eetlglaivv lstfihlspd laapllldim
     1801 qsvgrlasst tfsnqaesmm vpgnaagvak qflrcifhql apngifpqlf qstikdgtfl
     1861 rtlasslmdf nelssiaals qlleglnnkk nlpaggamir cleniatfme alpmdspssl
     1921 wttisnqfqt ffaklpcvlp lkcsldsslr imicllkips tnatrsllep fskllsfviq
     1981 navftlaylv elcglcyraf tkerdkfyls rsvvlellqa lklksplpdt nllllvqfic
     2041 adagtklaes tilskqmias vpgcgtaame cvrqyinevl dfmadmhtlt klkshmktcs
     2101 qplhedtfgg hlkvglaqia amdisrgnhr dnkavirylp wlyhppsamq qgpkefiecv
     2161 shirllswll lgslthnavc pnasspclpi pldagshvad hliviligfp eqsktsvlhm
     2221 cslfhafifa qlwtvyceqs avatnlqnqn efsftailta lefwsrvtps ilqlmahnkv
     2281 mvemvclhvi slmealqecn stifvklipm wlpmiqsnik hlsaglqlrl qaiqnhvnhh
     2341 slrtlpgsgq ssaglaalrk wlqctqfkma qveiqsseaa sqfypl
//
LOCUS       XP_016877008            2348 aa            linear   PRI 05-AUG-2025
DEFINITION  protein unc-79 homolog isoform X27 [Homo sapiens].
ACCESSION   XP_016877008
VERSION     XP_016877008.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021519.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2348
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2348
                     /product="protein unc-79 homolog isoform X27"
                     /calculated_mol_wt=262916
     Region          <16..286
                     /region_name="UNC-79"
                     /note="Cation-channel complex subunit UNC-79; pfam14776"
                     /db_xref="CDD:434201"
     CDS             1..2348
                     /gene="UNC79"
                     /gene_synonym="KIAA1409"
                     /coded_by="XM_017021519.2:635..7681"
                     /db_xref="GeneID:57578"
                     /db_xref="HGNC:HGNC:19966"
                     /db_xref="MIM:616884"
ORIGIN      
        1 mwtlhtsfkl fgmlincssh vrravvtcfs agccgrhgnr pvryckrchs nhhsnevgaa
       61 aethlyqtsp ppintrecga eelvcaveav isllkeaefh aeqrehelnr rrqlglsssh
      121 hsldnadfdn kdddkhdqrl lsqfgiwflv slctpsentp teslarlvam vfqwfhstay
      181 mmddevgslv eklkpqfvtk wlktvcdvrf dvmvmcllpk pmefarvggy wdkscstvtq
      241 lkeglnrilc lipynvinqs vwecimpewl eairtevpdn qlkefrevls kmfdielcpl
      301 pfsmeemfgf iscrftgyps svqeqallwl hvlseldimv plqllismfs dgvnsvkela
      361 nqrksrvsel agnlasrrvs vasdpgrrvq hnmlspfhsp fqspfrsplr spfrspfknf
      421 ghpggrtidf dceddemnln cfilmfdlll kqmelqddgi tmglehslsk diisiinnvf
      481 qapwggshtc qkdekaiecn lcqssilcyq lacellerla pkeesrlvep tdsledslls
      541 srpefiigpe geeeenpask hgenpgncte pvehaavknd terkfcyqql pvtlrliyti
      601 fqemakfeep dilfnmlncl kilclhgecl yiarkdhpqf layiqdhmli aslwrvvkse
      661 fsqlsslavp lllhalslph gadifwtiin gnfnskdwkm rfeavekvav icrfldihsv
      721 tknhllkysl ahafccflta vedvnpavat ragllldtik rpalqglclc ldfqfdtvvk
      781 drptilskll llhflkqdip alsweffvnr fetlsleaql hldcnkefpf pttitavrtn
      841 vanlsdaalw kikrarfarn rqksvrslrd svkgpveskr alslpetlts kipmrltrhe
      901 qsapalggtp eqtpgqqspe ndntikdllp edagidhqtv hqlitvlmkf makdessaes
      961 dissakafnt vkrhlyvllg ydqqegcfmi apqkmrlstc fnafiagiaq vmdyninlgk
     1021 hllplvvqvl kycscpqlrh yfqqpprcsl wslkphirqm wlkallvily kypyrdcdis
     1081 killhlihit vntlnaqyhs ckphatagpl ysdnsnisry sekekeedsv fdesdihdtp
     1141 tgpcnkesqt ffarlkrigg skmvkyqpve mnvqrseiel aeyretgalq dsllhcvree
     1201 sipkkklrsf kqksldigna dsllftldeh rrkscidrcd iekpptqaay iaqrpndpgr
     1261 srqnsatrpd nseipenpam egfpdarrpv ipevrlncme tfevkvdspv kpapkedldl
     1321 idlssdstsg pekhsilsts dsdslvfepl pplrivesde eeetmnqgdd gpsgknaass
     1381 psvpshpsvl slstaplvqv svedcskdfs skdsgnnqsa gntdsalitl edpmdaegss
     1441 kpeelpefsc gspltlkqkr dllqksfalp emslddhpdp gtegekpgel mpssgaktvl
     1501 lkvpedaenp tesekpdtsa esdteqnper kveedgaees efkiqivprq rkqrkiavsa
     1561 iqreyldisf nildklgeqk dpdpstkgls tlempresss aptldagvpe tsshssistq
     1621 yrqmkrgslg vltmsqlmkr qlehqssaph nisnwdteqi qpgkrqcnvp tclnpdlegq
     1681 plrmrgatks sllsapsivs mfvpapeeft deqptvmtdk chdcgailee ydeetlglai
     1741 vvlstfihls pdlaapllld imqsvgrlas sttfsnqaes mmvpgnaagv akqflrcifh
     1801 qlapngifpq lfqstikdgt flrtlasslm dfnelssiaa lsqlleglnn kknlpaggam
     1861 ircleniatf mealpmdsps slwttisnqf qtffaklpcv lplkcsldss lrimicllki
     1921 pstnatrsll epfskllsfv iqnavftlay lvelcglcyr aftkerdkfy lsrsvvlell
     1981 qalklksplp dtnllllvqf icadagtkla estilskqmi asvpgcgtaa mecvrqyine
     2041 vldfmadmht ltklkshmkt csqplhedtf gghlkvglaq iaamdisrgn hrdnkaviry
     2101 lpwlyhppsa mqqgpkefie cvshirllsw lllgslthna vcpnasspcl pipldagshv
     2161 adhlivilig fpeqsktsvl hmcslfhafi faqlwtvyce qsavatnlqn qnefsftail
     2221 talefwsrvt psilqlmahn kvmvemvclh vislmealqe cnstifvkli pmwlpmiqsn
     2281 ikhlsaglql rlqaiqnhvn hhslrtlpgs gqssaglaal rkwlqctqfk maqveiqsse
     2341 aasqfypl
//
LOCUS       XP_011535331            2339 aa            linear   PRI 05-AUG-2025
DEFINITION  protein unc-79 homolog isoform X28 [Homo sapiens].
ACCESSION   XP_011535331
VERSION     XP_011535331.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537029.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2339
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2339
                     /product="protein unc-79 homolog isoform X28"
                     /calculated_mol_wt=261903
     Region          <6..277
                     /region_name="UNC-79"
                     /note="Cation-channel complex subunit UNC-79; pfam14776"
                     /db_xref="CDD:434201"
     CDS             1..2339
                     /gene="UNC79"
                     /gene_synonym="KIAA1409"
                     /coded_by="XM_011537029.3:45..7064"
                     /db_xref="GeneID:57578"
                     /db_xref="HGNC:HGNC:19966"
                     /db_xref="MIM:616884"
ORIGIN      
        1 mffchkncss hvrravvtcf sagccgrhgn rpvryckrch snhhsnevga aaethlyqts
       61 pppintrecg aeelvcavea visllkeaef haeqreheln rrrqlglsss hhsldnadfd
      121 nkdddkhdqr llsqfgiwfl vslctpsent pteslarlva mvfqwfhsta ymmddevgsl
      181 veklkpqfvt kwlktvcdvr fdvmvmcllp kpmefarvgg ywdkscstvt qlkeglnril
      241 clipynvinq svwecimpew leairtevpd nqlkefrevl skmfdielcp lpfsmeemfg
      301 fiscrftgyp ssvqeqallw lhvlseldim vplqllismf sdgvnsvkel anqrksrvse
      361 lagnlasrrv svasdpgrrv qhnmlspfhs pfqspfrspl rspfrspfkn fghpggrtid
      421 fdceddemnl ncfilmfdll lkqmelqddg itmglehsls kdiisiinnv fqapwggsht
      481 cqkdekaiec nlcqssilcy qlacellerl apkeesrlve ptdsledsll ssrpefiigp
      541 egeeeenpas khgenpgnct epvehaavkn dterkfcyqq lpvtlrliyt ifqemakfee
      601 pdilfnmlnc lkilclhgec lyiarkdhpq flayiqdhml iaslwrvvks efsqlsslav
      661 plllhalslp hgadifwtii ngnfnskdwk mrfeavekva vicrfldihs vtknhllkys
      721 lahafccflt avedvnpava tragllldti krpalqglcl cldfqfdtvv kdrptilskl
      781 lllhflkqdi palsweffvn rfetlsleaq lhldcnkefp fpttitavrt nvanlsdaal
      841 wkikrarfar nrqksvrslr dsvkgpvesk ralslpetlt skipmrltrh eqsapalggt
      901 peqtpgqqsp endntikdll pedagidhqt vhqlitvlmk fmakdessae sdissakafn
      961 tvkrhlyvll gydqqegcfm iapqkmrlst cfnafiagia qvmdyninlg khllplvvqv
     1021 lkycscpqlr hyfqqpprcs lwslkphirq mwlkallvil ykypyrdcdi skillhlihi
     1081 tvntlnaqyh sckphatagp lysdnsnisr ysekekeeds vfdesdihdt ptgpcnkesq
     1141 tffarlkrig gskmvkyqpv emnvqrseie laeyretgal qdsllhcvre esipkkklrs
     1201 fkqksldign adsllftlde hrrkscidrc diekpptqaa yiaqrpndpg rsrqnsatrp
     1261 dnseipenpa megfpdarrp vipevrlncm etfevkvdsp vkpapkedld lidlssdsts
     1321 gpekhsilst sdsdslvfep lpplrivesd eeeetmnqgd dgpsgknaas spsvpshpsv
     1381 lslstaplvq vsvedcskdf sskdsgnnqs agntdsalit ledpmdaegs skpeelpefs
     1441 cgspltlkqk rdllqksfal pemslddhpd pgtegekpge lmpssgaktv llkvpedaen
     1501 ptesekpdts aesdteqnpe rkveedgaee sefkiqivpr qrkqrkiavs aiqreyldis
     1561 fnildklgeq kdpdpstkgl stlempress saptldagvp etsshssist qyrqmkrgsl
     1621 gvltmsqlmk rqlehqssap hnisnwdteq iqpgkrqcnv ptclnpdleg qplrmrgatk
     1681 ssllsapsiv smfvpapeef tdeqptvmtd kchdcgaile eydeetlgla ivvlstfihl
     1741 spdlaaplll dimqsvgrla ssttfsnqae smmvpgnaag vakqflrcif hqlapngifp
     1801 qlfqstikdg tflrtlassl mdfnelssia alsqllegln nkknlpagga mircleniat
     1861 fmealpmdsp sslwttisnq fqtffaklpc vlplkcslds slrimicllk ipstnatrsl
     1921 lepfskllsf viqnavftla ylvelcglcy raftkerdkf ylsrsvvlel lqalklkspl
     1981 pdtnllllvq ficadagtkl aestilskqm iasvpgcgta amecvrqyin evldfmadmh
     2041 tltklkshmk tcsqplhedt fgghlkvgla qiaamdisrg nhrdnkavir ylpwlyhpps
     2101 amqqgpkefi ecvshirlls wlllgslthn avcpnasspc lpipldagsh vadhlivili
     2161 gfpeqsktsv lhmcslfhaf ifaqlwtvyc eqsavatnlq nqnefsftai ltalefwsrv
     2221 tpsilqlmah nkvmvemvcl hvislmealq ecnstifvkl ipmwlpmiqs nikhlsaglq
     2281 lrlqaiqnhv nhhslrtlpg sgqssaglaa lrkwlqctqf kmaqveiqss eaasqfypl
//
LOCUS       XP_016877009            1956 aa            linear   PRI 05-AUG-2025
DEFINITION  protein unc-79 homolog isoform X29 [Homo sapiens].
ACCESSION   XP_016877009
VERSION     XP_016877009.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021520.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1956
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1956
                     /product="protein unc-79 homolog isoform X29"
                     /calculated_mol_wt=218185
     CDS             1..1956
                     /gene="UNC79"
                     /gene_synonym="KIAA1409"
                     /coded_by="XM_017021520.2:116..5986"
                     /db_xref="GeneID:57578"
                     /db_xref="HGNC:HGNC:19966"
                     /db_xref="MIM:616884"
ORIGIN      
        1 mlspfhspfq spfrsplrsp frspfknfgh pggrtidfdc eddemnlncf ilmfdlllkq
       61 melqddgitm glehslskdi isiinnvfqa pwggshtcqk dekaiecnlc qssilcyqla
      121 cellerlapk eesrlveptd sledsllssr pefiigpege eeenpaskhg enpgnctepv
      181 ehaavkndte rkfcyqqlpv tlrliytifq emakfeepdi lfnmlnclki lclhgeclyi
      241 arkdhpqfla yiqdhmlias lwrvvksefs qlsslavpll lhalslphga difwtiingn
      301 fnskdwkmrf eavekvavic rfldihsvtk nhllkyslah afccfltave dvnpavatra
      361 gllldtikrp alqglclcld fqfdtvvkdr ptilskllll hflkqdipal sweffvnrfe
      421 tlsleaqlhl dcnkefpfpt titavrtnva nlsdaalwki krarfarnrq ksvrslrdsv
      481 kgpveskral slpetltski pmrltrheqs apalggtpeq tpgqqspend ntikdllped
      541 agidhqtvhq litvlmkfma kdessaesdi ssakafntvk rhlyvllgyd qqegcfmiap
      601 qkmrlstcfn afiagiaqvm dyninlgkhl lplvvqvlky cscpqlrhyf qqpprcslws
      661 lkphirqmwl kallvilyky pyrdcdiski llhlihitvn tlnaqyhsck phatagplys
      721 dnsnisryse kekeedsvfd esdihdtptg pcnkesqtff arlkriggsk mvkyqpvemn
      781 vqrseielae yretgalqds llhcvreesi pkkklrsfkq ksldignads llftldehrr
      841 kscidrcdie kpptqaayia qrpndpgrsr qnsatrpdns eipenpameg fpdarrpvip
      901 evrlncmetf evkvdspvkp apkedldlid lssdstsgpe khsilstsds dslvfeplpp
      961 lrivesdeee etmnqgddgp sgknaassps vpshpsvlsl staplvqvsv edcskdfssk
     1021 dsgnnqsagn tdsalitled pmdaegsskp eelpefscgs pltlkqkrdl lqksfalpem
     1081 slddhpdpgt egekpgelmp ssgaktvllk vpedaenpte sekpdtsaes dteqnperkv
     1141 eedgaeesef kiqivprqrk qrkiavsaiq reyldisfni ldklgeqkdp dpstkglstl
     1201 empresssap tldagvpets shssistqyr qmkrgslgvl tmsqlmkrql ehqssaphni
     1261 snwdteqiqp gkrqcnvptc lnpdlegqpl rmrgatkssl lsapsivsmf vpapeeftde
     1321 qptvmtdkch dcgaileeyd eetlglaivv lstfihlspd laapllldim qsvgrlasst
     1381 tfsnqaesmm vpgnaagvak qflrcifhql apngifpqlf qstikdgtfl rtlasslmdf
     1441 nelssiaals qlleglnnkk nlpaggamir cleniatfme alpmdspssl wttisnqfqt
     1501 ffaklpcvlp lkcsldsslr imicllkips tnatrsllep fskllsfviq navftlaylv
     1561 elcglcyraf tkerdkfyls rsvvlellqa lklksplpdt nllllvqfic adagtklaes
     1621 tilskqmias vpgcgtaame cvrqyinevl dfmadmhtlt klkshmktcs qplhedtfgg
     1681 hlkvglaqia amdisrgnhr dnkavirylp wlyhppsamq qgpkefiecv shirllswll
     1741 lgslthnavc pnasspclpi pldagshvad hliviligfp eqsktsvlhm cslfhafifa
     1801 qlwtvyceqs avatnlqnqn efsftailta lefwsrvtps ilqlmahnkv mvemvclhvi
     1861 slmealqecn stifvklipm wlpmiqsnik hlsaglqlrl qaiqnhvnhh slrtlpgsgq
     1921 ssaglaalrk wlqctqfkma qveiqsseaa sqfypl
//
LOCUS       XP_024305438             623 aa            linear   PRI 05-AUG-2025
DEFINITION  brain-enriched guanylate kinase-associated protein isoform X1 [Homo
            sapiens].
ACCESSION   XP_024305438
VERSION     XP_024305438.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449670.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..623
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..623
                     /product="brain-enriched guanylate kinase-associated
                     protein isoform X1"
                     /calculated_mol_wt=68099
     Region          13..>162
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     CDS             1..623
                     /gene="BEGAIN"
                     /coded_by="XM_024449670.2:382..2253"
                     /db_xref="GeneID:57596"
                     /db_xref="HGNC:HGNC:24163"
                     /db_xref="MIM:618597"
ORIGIN      
        1 meklrlrspw vplclgqprv lqgrlarssp siwdsalqeq kgelrkrlsy tthkleklet
       61 efdstrhyle ielrraqeel ekvteklrri qsnymalqri nqeledklyr mgqhyeeekr
      121 alsheivaln shlleakvti dklsednely rkdcnlaaql lqcsqtygrv hkvselpsdf
      181 qervslhmek hgcslpsplc hpayadsvpt cviakvlekp dpaslssrls dasardlafc
      241 dgvekpgprp pykgdiycsd talycpeerr rdrrpsvdap vtdvgflraq nstdsaaeee
      301 eeaeaaafpa gfqheafpsy agslptsssy ssfsatseek ehaqastlta sqqaiylnsr
      361 delfdrkppa ttyegsprfa kataavaapl eaevapgfgr tmspypaetf rfpaspgpqq
      421 almppnlwsl rakpgtarlp gedmrgqwrp lsvedigays ypvsaagras pcsfseryyg
      481 gaggspgkka dgrasplyas ykadsfsegd dlsqghlaep cflraggdls lspgrsadpl
      541 pgyapseggd gdrlgvqlcg tasspepeqg srdslepssm easpemhpaa rlspqqafpr
      601 tggsglsrkd sltkaqlygt lln
//
LOCUS       XP_047287585             623 aa            linear   PRI 05-AUG-2025
DEFINITION  brain-enriched guanylate kinase-associated protein isoform X1 [Homo
            sapiens].
ACCESSION   XP_047287585
VERSION     XP_047287585.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431629.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 19% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..623
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..623
                     /product="brain-enriched guanylate kinase-associated
                     protein isoform X1"
                     /calculated_mol_wt=68099
     Region          13..>162
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     CDS             1..623
                     /gene="BEGAIN"
                     /coded_by="XM_047431629.1:662..2533"
                     /db_xref="GeneID:57596"
                     /db_xref="HGNC:HGNC:24163"
                     /db_xref="MIM:618597"
ORIGIN      
        1 meklrlrspw vplclgqprv lqgrlarssp siwdsalqeq kgelrkrlsy tthkleklet
       61 efdstrhyle ielrraqeel ekvteklrri qsnymalqri nqeledklyr mgqhyeeekr
      121 alsheivaln shlleakvti dklsednely rkdcnlaaql lqcsqtygrv hkvselpsdf
      181 qervslhmek hgcslpsplc hpayadsvpt cviakvlekp dpaslssrls dasardlafc
      241 dgvekpgprp pykgdiycsd talycpeerr rdrrpsvdap vtdvgflraq nstdsaaeee
      301 eeaeaaafpa gfqheafpsy agslptsssy ssfsatseek ehaqastlta sqqaiylnsr
      361 delfdrkppa ttyegsprfa kataavaapl eaevapgfgr tmspypaetf rfpaspgpqq
      421 almppnlwsl rakpgtarlp gedmrgqwrp lsvedigays ypvsaagras pcsfseryyg
      481 gaggspgkka dgrasplyas ykadsfsegd dlsqghlaep cflraggdls lspgrsadpl
      541 pgyapseggd gdrlgvqlcg tasspepeqg srdslepssm easpemhpaa rlspqqafpr
      601 tggsglsrkd sltkaqlygt lln
//
LOCUS       XP_024305439             614 aa            linear   PRI 05-AUG-2025
DEFINITION  brain-enriched guanylate kinase-associated protein isoform X2 [Homo
            sapiens].
ACCESSION   XP_024305439
VERSION     XP_024305439.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449671.2
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XP_024305439.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 6% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..614
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..614
                     /product="brain-enriched guanylate kinase-associated
                     protein isoform X2"
                     /calculated_mol_wt=66931
     Region          32..>174
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     CDS             1..614
                     /gene="BEGAIN"
                     /coded_by="XM_024449671.2:128..1972"
                     /db_xref="GeneID:57596"
                     /db_xref="HGNC:HGNC:24163"
                     /db_xref="MIM:618597"
ORIGIN      
        1 mwtggrrpgr lrraasaadm eklrlrspwv plclgqprvl qgrlarssps iwdsalqeqk
       61 gelrkrlsyt thkleklete fdstrhylei elrraqeele kvteklrriq snymalqrin
      121 qeledklyrm gqhyeeekra lsheivalns hlleakvtid klsednlpsd fqervslhme
      181 khgcslpspl chpayadsvp tcviakvlek pdpaslssrl sdasardlaf cdgvekpgpr
      241 ppykgdiycs dtalycpeer rrdrrpsvda pvtdvgflra qnstdsaaee eeeaeaaafp
      301 agfqheafps yagslptsss yssfsatsee kehaqastlt asqqaiylns rdelfdrkpp
      361 attyegsprf akataavaap leaevapgfg rtmspypaet frfpaspgpq qalmppnlws
      421 lrakpgtarl pgedmrgqwr plsvedigay sypvsaagra spcsfseryy ggaggspgkk
      481 adgrasplya sykadsfseg ddlsqghlae pcflraggdl slspgrsadp lpgyapsegg
      541 dgdrlgvqlc gtasspepeq gsrdslepss measpemhpa arlspqqafp rtggsglsrk
      601 dsltkaqlyg tlln
//
LOCUS       XP_047287586             577 aa            linear   PRI 05-AUG-2025
DEFINITION  brain-enriched guanylate kinase-associated protein isoform X3 [Homo
            sapiens].
ACCESSION   XP_047287586
VERSION     XP_047287586.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431630.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..577
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..577
                     /product="brain-enriched guanylate kinase-associated
                     protein isoform X3"
                     /calculated_mol_wt=62570
     Region          14..>137
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     CDS             1..577
                     /gene="BEGAIN"
                     /coded_by="XM_047431630.1:29..1762"
                     /db_xref="GeneID:57596"
                     /db_xref="HGNC:HGNC:24163"
                     /db_xref="MIM:618597"
ORIGIN      
        1 mpspsdcasa admeklsalq eqkgelrkrl sytthklekl etefdstrhy leielrraqe
       61 elekvteklr riqsnymalq rinqeledkl yrmgqhyeee kralsheiva lnshlleakv
      121 tidklsednl psdfqervsl hmekhgcslp splchpayad svptcviakv lekpdpasls
      181 srlsdasard lafcdgvekp gprppykgdi ycsdtalycp eerrrdrrps vdapvtdvgf
      241 lraqnstdsa aeeeeeaeaa afpagfqhea fpsyagslpt sssyssfsat seekehaqas
      301 tltasqqaiy lnsrdelfdr kppattyegs prfakataav aapleaevap gfgrtmspyp
      361 aetfrfpasp gpqqalmppn lwslrakpgt arlpgedmrg qwrplsvedi gaysypvsaa
      421 graspcsfse ryyggaggsp gkkadgrasp lyasykadsf segddlsqgh laepcflrag
      481 gdlslspgrs adplpgyaps eggdgdrlgv qlcgtasspe peqgsrdsle pssmeaspem
      541 hpaarlspqq afprtggsgl srkdsltkaq lygtlln
//
LOCUS       XP_011535336            2053 aa            linear   PRI 05-AUG-2025
DEFINITION  Fanconi anemia group M protein isoform X1 [Homo sapiens].
ACCESSION   XP_011535336
VERSION     XP_011535336.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537034.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2053
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2053
                     /product="Fanconi anemia group M protein isoform X1"
                     /calculated_mol_wt=232667
     Region          89..270
                     /region_name="DEXDc_FANCM"
                     /note="DEAH-box helicase domain of FANCM; cd18033"
                     /db_xref="CDD:350791"
     Site            order(89..92,95,112..119,154,215,246)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:350791"
     Region          92..>619
                     /region_name="MPH1"
                     /note="ERCC4-related helicase [Replication, recombination
                     and repair]; COG1111"
                     /db_xref="CDD:440728"
     Site            order(142..143,169..170,190,192..193,196,221..223)
                     /site_type="other"
                     /note="nucleic acid binding site [nucleotide binding]"
                     /db_xref="CDD:350791"
     Region          675..790
                     /region_name="FANCM-MHF_bd"
                     /note="FANCM to MHF binding domain; pfam16783"
                     /db_xref="CDD:465270"
     Region          1510..>1593
                     /region_name="MRC1"
                     /note="MRC1-like domain; pfam09444"
                     /db_xref="CDD:430616"
     Region          1823..1961
                     /region_name="XPF_nuclease_FANCM"
                     /note="XPF-like nuclease domain of Fanconi anemia group M
                     protein (FANCM); cd20077"
                     /db_xref="CDD:410853"
     Site            order(1859,1869)
                     /site_type="other"
                     /note="Ca binding site [ion binding]"
                     /db_xref="CDD:410853"
     Site            order(1886,1889..1890,1893,1919,1921,1924..1925,
                     1927..1929,1931..1933,1935,1938..1939,1945,1948..1949,
                     1952..1953,1956)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:410853"
     CDS             1..2053
                     /gene="FANCM"
                     /gene_synonym="FAAP250; KIAA1596; POF15; SPGF28"
                     /coded_by="XM_011537034.3:103..6264"
                     /db_xref="GeneID:57697"
                     /db_xref="HGNC:HGNC:23168"
                     /db_xref="MIM:609644"
ORIGIN      
        1 msgrqrtlfq twgssisrss gtpgcssgte rpqspgsska plpaaaeaql esdddvllva
       61 ayeaerqlcl enggfctsag alwiyptncp vrdyqlhisr aalfcntlvc lptglgktfi
      121 aavvmynfyr wfpsgkvvfm aptkplvtqq ieacyqvmgi pqshmaemtg stqastrkei
      181 wcskrvlflt pqvmvndlsr gacpaaeikc lvideahkal gnyaycqvvr elvkytnhfr
      241 ilalsatpgs dikavqqvit nlligqielr sedspdilty sherkvekli vplgeelaai
      301 qktyiqiles farsliqrnv lmrrdipnlt kyqiilardq frknpspniv giqqgiiege
      361 faicislyhg yellqqmgmr slyfflcgim dgtkgmtrsk nelgrnedfm klynhlecmf
      421 artrstsang isaiqqgdkn kkfvyshpkl kkleevvieh fkswnaentt ekkrdetrvm
      481 ifssfrdsvq eiaemlsqhq piirvmtfvg hasgkstkgf tqkeqlevvk qfrdggyntl
      541 vstcvgeegl digevdliic fdsqkspirl vqrmgrtgrk rqgriviils egreeriynq
      601 sqsnkrsiyk aissnrqvlh fyqrsprmvp dginpklhkm fithgvyepe kpsrnlqrks
      661 sifsyrdgmr qsslkkdwfl seeefklwnr lyrlrdsdei keitlpqvqf sslqneenkp
      721 aqesttgihq lslsewrlwq dhplpthqvd hsdrcrhfig lmqmiegmrh eegecsyele
      781 vesylqmedv tstfiaprne snnlasdtfi thkkssfikn inqgssssvi esdeecaeiv
      841 kqthikptki vslkkkvske ikkdqlkken nhgiidsvdn drnstvenif qedlpndkrt
      901 sdtdeiaatc tinenvikep cvlltecqft nkstsslagn vldsgynsfn deksvssnlf
      961 lpfeeelyiv rtddqfynch sltkevlanv erflsysppp lsglsdleye iakgtalenl
     1021 lflpcaehlr sdkctcllsh savnsqqnle lnslkcinyp seksclydip ndnisdepsl
     1081 cdcdvhkhnq nenlvpnnrv qihrspaqnl vgennhdvdn sdlpvlstdq deslllfedv
     1141 ntefddvsls plnskseslp vsdktaiset plvsqflisd ellldnnsel qdqitrdans
     1201 fksrdqrgvq eekvknhedi fdcsrdlfsv tfdlgfcspd sddeilehts dsnrplddly
     1261 gryleikeis danyvsnqal iprdhsknft sgtviipsne dmqnpnyvhl plsaakneel
     1321 lspgysqfsl pvqkkvmstp lsksntlnsf skirkeilkt pdsskekvnl qrfkealnst
     1381 fdysefslek skssgpmylh kschsvedgq lltsnesedd eifrrkvkra kgnvlnsped
     1441 qknsevdspl havkkrrfpi nrvskyqsel sssdesenfp kpcsqledfk vcngnarrgi
     1501 kvpkrqshlk hvarkfldde aelseedaey vssdendese neqdsslldf lndetqlsqa
     1561 indsemraiy mkslrspmmn nkykmihkth kninifsqip eqdetyleds fcvdeeesck
     1621 gqsseeevcv dfnlitddcf anskkyktrr avmlkemmeq ncahskkkls riilpddsse
     1681 eennvndkre sniavnpstv kknkqqdhcl nsvpsgssaq skvrstprvn plakqskqts
     1741 lnlkdtisev sdfkpqnhne vqsttppftt vdsqkdcrkf pvpqkdgsal edsstsgasc
     1801 sksrphlagt htslrlpqeg kgtcilvggh eitsglevis slraihglqv evcplngcdy
     1861 ivsnrmvver rsqsemlnsv nknkfieqiq hlqsmferic vivekdrekt gdtsrmfrrt
     1921 ksydsllttl igagirilfs scqeetadll kelslveqrk nvgihvptvv nsnksealqf
     1981 ylsipnisyi talnmchqfs svkrmanssl qeismyaqvt hqkaeeiyry ihyvfdiqml
     2041 pndlnqdrlk sdi
//
LOCUS       XP_011535337            2027 aa            linear   PRI 05-AUG-2025
DEFINITION  Fanconi anemia group M protein isoform X2 [Homo sapiens].
ACCESSION   XP_011535337
VERSION     XP_011535337.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537035.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2027
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2027
                     /product="Fanconi anemia group M protein isoform X2"
                     /calculated_mol_wt=229757
     Region          92..>593
                     /region_name="MPH1"
                     /note="ERCC4-related helicase [Replication, recombination
                     and repair]; COG1111"
                     /db_xref="CDD:440728"
     Region          649..764
                     /region_name="FANCM-MHF_bd"
                     /note="FANCM to MHF binding domain; pfam16783"
                     /db_xref="CDD:465270"
     Region          1484..>1567
                     /region_name="MRC1"
                     /note="MRC1-like domain; pfam09444"
                     /db_xref="CDD:430616"
     Region          1797..1935
                     /region_name="XPF_nuclease_FANCM"
                     /note="XPF-like nuclease domain of Fanconi anemia group M
                     protein (FANCM); cd20077"
                     /db_xref="CDD:410853"
     Site            order(1833,1843)
                     /site_type="other"
                     /note="Ca binding site [ion binding]"
                     /db_xref="CDD:410853"
     Site            order(1860,1863..1864,1867,1893,1895,1898..1899,
                     1901..1903,1905..1907,1909,1912..1913,1919,1922..1923,
                     1926..1927,1930)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:410853"
     CDS             1..2027
                     /gene="FANCM"
                     /gene_synonym="FAAP250; KIAA1596; POF15; SPGF28"
                     /coded_by="XM_011537035.4:103..6186"
                     /db_xref="GeneID:57697"
                     /db_xref="HGNC:HGNC:23168"
                     /db_xref="MIM:609644"
ORIGIN      
        1 msgrqrtlfq twgssisrss gtpgcssgte rpqspgsska plpaaaeaql esdddvllva
       61 ayeaerqlcl enggfctsag alwiyptncp vrdyqlhisr aalfcntlvc lptglgktfi
      121 aavvmynfyr wfpsgkvvfm aptkplvtqq ieacyqvmgi pqshmaemtg stqastrkei
      181 wcskrvlflt pqvmvndlsr gacpaaeikc lvideahkal gnyaycqavq qvitnlligq
      241 ielrsedspd iltysherkv eklivplgee laaiqktyiq ilesfarsli qrnvlmrrdi
      301 pnltkyqiil ardqfrknps pnivgiqqgi iegefaicis lyhgyellqq mgmrslyffl
      361 cgimdgtkgm trsknelgrn edfmklynhl ecmfartrst sangisaiqq gdknkkfvys
      421 hpklkkleev viehfkswna enttekkrde trvmifssfr dsvqeiaeml sqhqpiirvm
      481 tfvghasgks tkgftqkeql evvkqfrdgg yntlvstcvg eegldigevd liicfdsqks
      541 pirlvqrmgr tgrkrqgriv iilsegreer iynqsqsnkr siykaissnr qvlhfyqrsp
      601 rmvpdginpk lhkmfithgv yepekpsrnl qrkssifsyr dgmrqsslkk dwflseeefk
      661 lwnrlyrlrd sdeikeitlp qvqfsslqne enkpaqestt gihqlslsew rlwqdhplpt
      721 hqvdhsdrcr hfiglmqmie gmrheegecs yelevesylq medvtstfia prnesnnlas
      781 dtfithkkss fikninqgss ssviesdeec aeivkqthik ptkivslkkk vskeikkdql
      841 kkennhgiid svdndrnstv enifqedlpn dkrtsdtdei aatctinenv ikepcvllte
      901 cqftnkstss lagnvldsgy nsfndeksvs snlflpfeee lyivrtddqf ynchsltkev
      961 lanverflsy sppplsglsd leyeiakgta lenllflpca ehlrsdkctc llshsavnsq
     1021 qnlelnslkc inypsekscl ydipndnisd epslcdcdvh khnqnenlvp nnrvqihrsp
     1081 aqnlvgennh dvdnsdlpvl stdqdeslll fedvntefdd vslsplnsks eslpvsdkta
     1141 isetplvsqf lisdellldn nselqdqitr dansfksrdq rgvqeekvkn hedifdcsrd
     1201 lfsvtfdlgf cspdsddeil ehtsdsnrpl ddlygrylei keisdanyvs nqaliprdhs
     1261 knftsgtvii psnedmqnpn yvhlplsaak neellspgys qfslpvqkkv mstplsksnt
     1321 lnsfskirke ilktpdsske kvnlqrfkea lnstfdysef slekskssgp mylhkschsv
     1381 edgqlltsne seddeifrrk vkrakgnvln spedqknsev dsplhavkkr rfpinrvsky
     1441 qselsssdes enfpkpcsql edfkvcngna rrgikvpkrq shlkhvarkf lddeaelsee
     1501 daeyvssden deseneqdss lldflndetq lsqaindsem raiymkslrs pmmnnkykmi
     1561 hkthkninif sqipeqdety ledsfcvdee esckgqssee evcvdfnlit ddcfanskky
     1621 ktrravmlke mmeqncahsk kklsriilpd dsseeennvn dkresniavn pstvkknkqq
     1681 dhclnsvpsg ssaqskvrst prvnplakqs kqtslnlkdt isevsdfkpq nhnevqsttp
     1741 pfttvdsqkd crkfpvpqkd gsaledssts gascsksrph lagthtslrl pqegkgtcil
     1801 vggheitsgl evisslraih glqvevcpln gcdyivsnrm vverrsqsem lnsvnknkfi
     1861 eqiqhlqsmf ericvivekd rektgdtsrm frrtksydsl lttligagir ilfsscqeet
     1921 adllkelslv eqrknvgihv ptvvnsnkse alqfylsipn isyitalnmc hqfssvkrma
     1981 nsslqeismy aqvthqkaee iyryihyvfd iqmlpndlnq drlksdi
//
LOCUS       XP_016877012            1801 aa            linear   PRI 05-AUG-2025
DEFINITION  Fanconi anemia group M protein isoform X3 [Homo sapiens].
ACCESSION   XP_016877012
VERSION     XP_016877012.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021523.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1801
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1801
                     /product="Fanconi anemia group M protein isoform X3"
                     /calculated_mol_wt=204255
     Region          89..270
                     /region_name="DEXDc_FANCM"
                     /note="DEAH-box helicase domain of FANCM; cd18033"
                     /db_xref="CDD:350791"
     Site            order(89..92,95,112..119,154,215,246)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:350791"
     Region          92..>619
                     /region_name="MPH1"
                     /note="ERCC4-related helicase [Replication, recombination
                     and repair]; COG1111"
                     /db_xref="CDD:440728"
     Site            order(142..143,169..170,190,192..193,196,221..223)
                     /site_type="other"
                     /note="nucleic acid binding site [nucleotide binding]"
                     /db_xref="CDD:350791"
     Region          675..790
                     /region_name="FANCM-MHF_bd"
                     /note="FANCM to MHF binding domain; pfam16783"
                     /db_xref="CDD:465270"
     Region          1510..>1593
                     /region_name="MRC1"
                     /note="MRC1-like domain; pfam09444"
                     /db_xref="CDD:430616"
     CDS             1..1801
                     /gene="FANCM"
                     /gene_synonym="FAAP250; KIAA1596; POF15; SPGF28"
                     /coded_by="XM_017021523.2:103..5508"
                     /db_xref="GeneID:57697"
                     /db_xref="HGNC:HGNC:23168"
                     /db_xref="MIM:609644"
ORIGIN      
        1 msgrqrtlfq twgssisrss gtpgcssgte rpqspgsska plpaaaeaql esdddvllva
       61 ayeaerqlcl enggfctsag alwiyptncp vrdyqlhisr aalfcntlvc lptglgktfi
      121 aavvmynfyr wfpsgkvvfm aptkplvtqq ieacyqvmgi pqshmaemtg stqastrkei
      181 wcskrvlflt pqvmvndlsr gacpaaeikc lvideahkal gnyaycqvvr elvkytnhfr
      241 ilalsatpgs dikavqqvit nlligqielr sedspdilty sherkvekli vplgeelaai
      301 qktyiqiles farsliqrnv lmrrdipnlt kyqiilardq frknpspniv giqqgiiege
      361 faicislyhg yellqqmgmr slyfflcgim dgtkgmtrsk nelgrnedfm klynhlecmf
      421 artrstsang isaiqqgdkn kkfvyshpkl kkleevvieh fkswnaentt ekkrdetrvm
      481 ifssfrdsvq eiaemlsqhq piirvmtfvg hasgkstkgf tqkeqlevvk qfrdggyntl
      541 vstcvgeegl digevdliic fdsqkspirl vqrmgrtgrk rqgriviils egreeriynq
      601 sqsnkrsiyk aissnrqvlh fyqrsprmvp dginpklhkm fithgvyepe kpsrnlqrks
      661 sifsyrdgmr qsslkkdwfl seeefklwnr lyrlrdsdei keitlpqvqf sslqneenkp
      721 aqesttgihq lslsewrlwq dhplpthqvd hsdrcrhfig lmqmiegmrh eegecsyele
      781 vesylqmedv tstfiaprne snnlasdtfi thkkssfikn inqgssssvi esdeecaeiv
      841 kqthikptki vslkkkvske ikkdqlkken nhgiidsvdn drnstvenif qedlpndkrt
      901 sdtdeiaatc tinenvikep cvlltecqft nkstsslagn vldsgynsfn deksvssnlf
      961 lpfeeelyiv rtddqfynch sltkevlanv erflsysppp lsglsdleye iakgtalenl
     1021 lflpcaehlr sdkctcllsh savnsqqnle lnslkcinyp seksclydip ndnisdepsl
     1081 cdcdvhkhnq nenlvpnnrv qihrspaqnl vgennhdvdn sdlpvlstdq deslllfedv
     1141 ntefddvsls plnskseslp vsdktaiset plvsqflisd ellldnnsel qdqitrdans
     1201 fksrdqrgvq eekvknhedi fdcsrdlfsv tfdlgfcspd sddeilehts dsnrplddly
     1261 gryleikeis danyvsnqal iprdhsknft sgtviipsne dmqnpnyvhl plsaakneel
     1321 lspgysqfsl pvqkkvmstp lsksntlnsf skirkeilkt pdsskekvnl qrfkealnst
     1381 fdysefslek skssgpmylh kschsvedgq lltsnesedd eifrrkvkra kgnvlnsped
     1441 qknsevdspl havkkrrfpi nrvskyqsel sssdesenfp kpcsqledfk vcngnarrgi
     1501 kvpkrqshlk hvarkfldde aelseedaey vssdendese neqdsslldf lndetqlsqa
     1561 indsemraiy mkslrspmmn nkykmihkth kninifsqip eqdetyleds fcvdeeesck
     1621 gqsseeevcv dfnlitddcf anskkyktrr avmlkemmeq ncahskkkls riilpddsse
     1681 eennvndkre sniavnpstv kknkqqdhcl nsvpsgssaq skvrstprvn plakqskqts
     1741 lnlkdtisev sdfkpqnhne vqsttppftt vdsqkdcrkf pvpqkltsrn lhvctsnsse
     1801 g
//
LOCUS       XP_047287587            1801 aa            linear   PRI 05-AUG-2025
DEFINITION  Fanconi anemia group M protein isoform X4 [Homo sapiens].
ACCESSION   XP_047287587
VERSION     XP_047287587.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431631.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1801
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1801
                     /product="Fanconi anemia group M protein isoform X4"
                     /calculated_mol_wt=204285
     Region          89..270
                     /region_name="DEXDc_FANCM"
                     /note="DEAH-box helicase domain of FANCM; cd18033"
                     /db_xref="CDD:350791"
     Site            order(89..92,95,112..119,154,215,246)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:350791"
     Region          92..>619
                     /region_name="MPH1"
                     /note="ERCC4-related helicase [Replication, recombination
                     and repair]; COG1111"
                     /db_xref="CDD:440728"
     Site            order(142..143,169..170,190,192..193,196,221..223)
                     /site_type="other"
                     /note="nucleic acid binding site [nucleotide binding]"
                     /db_xref="CDD:350791"
     Region          675..790
                     /region_name="FANCM-MHF_bd"
                     /note="FANCM to MHF binding domain; pfam16783"
                     /db_xref="CDD:465270"
     Region          1510..>1593
                     /region_name="MRC1"
                     /note="MRC1-like domain; pfam09444"
                     /db_xref="CDD:430616"
     CDS             1..1801
                     /gene="FANCM"
                     /gene_synonym="FAAP250; KIAA1596; POF15; SPGF28"
                     /coded_by="XM_047431631.1:103..5508"
                     /db_xref="GeneID:57697"
                     /db_xref="HGNC:HGNC:23168"
                     /db_xref="MIM:609644"
ORIGIN      
        1 msgrqrtlfq twgssisrss gtpgcssgte rpqspgsska plpaaaeaql esdddvllva
       61 ayeaerqlcl enggfctsag alwiyptncp vrdyqlhisr aalfcntlvc lptglgktfi
      121 aavvmynfyr wfpsgkvvfm aptkplvtqq ieacyqvmgi pqshmaemtg stqastrkei
      181 wcskrvlflt pqvmvndlsr gacpaaeikc lvideahkal gnyaycqvvr elvkytnhfr
      241 ilalsatpgs dikavqqvit nlligqielr sedspdilty sherkvekli vplgeelaai
      301 qktyiqiles farsliqrnv lmrrdipnlt kyqiilardq frknpspniv giqqgiiege
      361 faicislyhg yellqqmgmr slyfflcgim dgtkgmtrsk nelgrnedfm klynhlecmf
      421 artrstsang isaiqqgdkn kkfvyshpkl kkleevvieh fkswnaentt ekkrdetrvm
      481 ifssfrdsvq eiaemlsqhq piirvmtfvg hasgkstkgf tqkeqlevvk qfrdggyntl
      541 vstcvgeegl digevdliic fdsqkspirl vqrmgrtgrk rqgriviils egreeriynq
      601 sqsnkrsiyk aissnrqvlh fyqrsprmvp dginpklhkm fithgvyepe kpsrnlqrks
      661 sifsyrdgmr qsslkkdwfl seeefklwnr lyrlrdsdei keitlpqvqf sslqneenkp
      721 aqesttgihq lslsewrlwq dhplpthqvd hsdrcrhfig lmqmiegmrh eegecsyele
      781 vesylqmedv tstfiaprne snnlasdtfi thkkssfikn inqgssssvi esdeecaeiv
      841 kqthikptki vslkkkvske ikkdqlkken nhgiidsvdn drnstvenif qedlpndkrt
      901 sdtdeiaatc tinenvikep cvlltecqft nkstsslagn vldsgynsfn deksvssnlf
      961 lpfeeelyiv rtddqfynch sltkevlanv erflsysppp lsglsdleye iakgtalenl
     1021 lflpcaehlr sdkctcllsh savnsqqnle lnslkcinyp seksclydip ndnisdepsl
     1081 cdcdvhkhnq nenlvpnnrv qihrspaqnl vgennhdvdn sdlpvlstdq deslllfedv
     1141 ntefddvsls plnskseslp vsdktaiset plvsqflisd ellldnnsel qdqitrdans
     1201 fksrdqrgvq eekvknhedi fdcsrdlfsv tfdlgfcspd sddeilehts dsnrplddly
     1261 gryleikeis danyvsnqal iprdhsknft sgtviipsne dmqnpnyvhl plsaakneel
     1321 lspgysqfsl pvqkkvmstp lsksntlnsf skirkeilkt pdsskekvnl qrfkealnst
     1381 fdysefslek skssgpmylh kschsvedgq lltsnesedd eifrrkvkra kgnvlnsped
     1441 qknsevdspl havkkrrfpi nrvskyqsel sssdesenfp kpcsqledfk vcngnarrgi
     1501 kvpkrqshlk hvarkfldde aelseedaey vssdendese neqdsslldf lndetqlsqa
     1561 indsemraiy mkslrspmmn nkykmihkth kninifsqip eqdetyleds fcvdeeesck
     1621 gqsseeevcv dfnlitddcf anskkyktrr avmlkemmeq ncahskkkls riilpddsse
     1681 eennvndkre sniavnpstv kknkqqdhcl nsvpsgssaq skvrstprvn plakqskqts
     1741 lnlkdtisev sdfkpqnhne vqsttppftt vdsqkdcrkf pvpqkethqg clgeqramta
     1801 c
//
LOCUS       XP_047287588            1796 aa            linear   PRI 05-AUG-2025
DEFINITION  Fanconi anemia group M protein isoform X5 [Homo sapiens].
ACCESSION   XP_047287588
VERSION     XP_047287588.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431632.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1796
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1796
                     /product="Fanconi anemia group M protein isoform X5"
                     /calculated_mol_wt=203649
     Region          89..270
                     /region_name="DEXDc_FANCM"
                     /note="DEAH-box helicase domain of FANCM; cd18033"
                     /db_xref="CDD:350791"
     Site            order(89..92,95,112..119,154,215,246)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:350791"
     Region          92..>619
                     /region_name="MPH1"
                     /note="ERCC4-related helicase [Replication, recombination
                     and repair]; COG1111"
                     /db_xref="CDD:440728"
     Site            order(142..143,169..170,190,192..193,196,221..223)
                     /site_type="other"
                     /note="nucleic acid binding site [nucleotide binding]"
                     /db_xref="CDD:350791"
     Region          675..790
                     /region_name="FANCM-MHF_bd"
                     /note="FANCM to MHF binding domain; pfam16783"
                     /db_xref="CDD:465270"
     Region          1505..>1588
                     /region_name="MRC1"
                     /note="MRC1-like domain; pfam09444"
                     /db_xref="CDD:430616"
     CDS             1..1796
                     /gene="FANCM"
                     /gene_synonym="FAAP250; KIAA1596; POF15; SPGF28"
                     /coded_by="XM_047431632.1:103..5493"
                     /db_xref="GeneID:57697"
                     /db_xref="HGNC:HGNC:23168"
                     /db_xref="MIM:609644"
ORIGIN      
        1 msgrqrtlfq twgssisrss gtpgcssgte rpqspgsska plpaaaeaql esdddvllva
       61 ayeaerqlcl enggfctsag alwiyptncp vrdyqlhisr aalfcntlvc lptglgktfi
      121 aavvmynfyr wfpsgkvvfm aptkplvtqq ieacyqvmgi pqshmaemtg stqastrkei
      181 wcskrvlflt pqvmvndlsr gacpaaeikc lvideahkal gnyaycqvvr elvkytnhfr
      241 ilalsatpgs dikavqqvit nlligqielr sedspdilty sherkvekli vplgeelaai
      301 qktyiqiles farsliqrnv lmrrdipnlt kyqiilardq frknpspniv giqqgiiege
      361 faicislyhg yellqqmgmr slyfflcgim dgtkgmtrsk nelgrnedfm klynhlecmf
      421 artrstsang isaiqqgdkn kkfvyshpkl kkleevvieh fkswnaentt ekkrdetrvm
      481 ifssfrdsvq eiaemlsqhq piirvmtfvg hasgkstkgf tqkeqlevvk qfrdggyntl
      541 vstcvgeegl digevdliic fdsqkspirl vqrmgrtgrk rqgriviils egreeriynq
      601 sqsnkrsiyk aissnrqvlh fyqrsprmvp dginpklhkm fithgvyepe kpsrnlqrks
      661 sifsyrdgmr qsslkkdwfl seeefklwnr lyrlrdsdei keitlpqvqf sslqneenkp
      721 aqesttgihq lslsewrlwq dhplpthqvd hsdrcrhfig lmqmiegmrh eegecsyele
      781 vesylqmedv tstfiaprne snnlasdtfi thkkssfikn inqgssssvi esdeecaeiv
      841 kqthikptki vslkkkvske ikkdqlkken nhgiidsvdn drnstvenif qedlpndkrt
      901 sdtdeiaatc tinenvikep cvlltecqft nkstsslagn vldsgynsfn deksvssnlf
      961 lpfeeelyiv rtddqfynch sltkevlanv erflsysppp lsglsdleye iakgtalenl
     1021 lflpcaehlr sdkctcllsh savnsqqnle lnslkcinyp seksclydip ndnisdepsl
     1081 cdcdvhkhnq nenlvpnnrv qihrspaqnl vgennhdvdn sdlpvlstdq deslllfedv
     1141 ntefddvsls plnskseslp vsdktaiset plvsqflisd ellldnnsel qdqitrdans
     1201 fksrdqrgvq eekvknhedi fdcsrdlfsv tfdlgfcspd sddeilehts dsnrplddly
     1261 gryleikeis danyvsnqal iprdhsknft sgtviipsne dmqnpnyvhl plsaakneel
     1321 lspgysqfsl pvqkkvmstp lsksntlnsf skirkeilkt pdsskekvnl qrfkealnst
     1381 fdysefslek skssgpmylh kschsvedgq lltsnesedd eifrrkvkra kgnvlnsped
     1441 qknsevdspl havkkrrfpi nrselsssde senfpkpcsq ledfkvcngn arrgikvpkr
     1501 qshlkhvark flddeaelse edaeyvssde ndeseneqds slldflndet qlsqaindse
     1561 mraiymkslr spmmnnkykm ihkthknini fsqipeqdet yledsfcvde eesckgqsse
     1621 eevcvdfnli tddcfanskk yktrravmlk emmeqncahs kkklsriilp ddsseeennv
     1681 ndkresniav npstvkknkq qdhclnsvps gssaqskvrs tprvnplakq skqtslnlkd
     1741 tisevsdfkp qnhnevqstt ppfttvdsqk dcrkfpvpqk ltsrnlhvct snsseg
//
LOCUS       XP_047287589            1796 aa            linear   PRI 05-AUG-2025
DEFINITION  Fanconi anemia group M protein isoform X6 [Homo sapiens].
ACCESSION   XP_047287589
VERSION     XP_047287589.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431633.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1796
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1796
                     /product="Fanconi anemia group M protein isoform X6"
                     /calculated_mol_wt=203679
     Region          89..270
                     /region_name="DEXDc_FANCM"
                     /note="DEAH-box helicase domain of FANCM; cd18033"
                     /db_xref="CDD:350791"
     Site            order(89..92,95,112..119,154,215,246)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:350791"
     Region          92..>619
                     /region_name="MPH1"
                     /note="ERCC4-related helicase [Replication, recombination
                     and repair]; COG1111"
                     /db_xref="CDD:440728"
     Site            order(142..143,169..170,190,192..193,196,221..223)
                     /site_type="other"
                     /note="nucleic acid binding site [nucleotide binding]"
                     /db_xref="CDD:350791"
     Region          675..790
                     /region_name="FANCM-MHF_bd"
                     /note="FANCM to MHF binding domain; pfam16783"
                     /db_xref="CDD:465270"
     Region          1505..>1588
                     /region_name="MRC1"
                     /note="MRC1-like domain; pfam09444"
                     /db_xref="CDD:430616"
     CDS             1..1796
                     /gene="FANCM"
                     /gene_synonym="FAAP250; KIAA1596; POF15; SPGF28"
                     /coded_by="XM_047431633.1:103..5493"
                     /db_xref="GeneID:57697"
                     /db_xref="HGNC:HGNC:23168"
                     /db_xref="MIM:609644"
ORIGIN      
        1 msgrqrtlfq twgssisrss gtpgcssgte rpqspgsska plpaaaeaql esdddvllva
       61 ayeaerqlcl enggfctsag alwiyptncp vrdyqlhisr aalfcntlvc lptglgktfi
      121 aavvmynfyr wfpsgkvvfm aptkplvtqq ieacyqvmgi pqshmaemtg stqastrkei
      181 wcskrvlflt pqvmvndlsr gacpaaeikc lvideahkal gnyaycqvvr elvkytnhfr
      241 ilalsatpgs dikavqqvit nlligqielr sedspdilty sherkvekli vplgeelaai
      301 qktyiqiles farsliqrnv lmrrdipnlt kyqiilardq frknpspniv giqqgiiege
      361 faicislyhg yellqqmgmr slyfflcgim dgtkgmtrsk nelgrnedfm klynhlecmf
      421 artrstsang isaiqqgdkn kkfvyshpkl kkleevvieh fkswnaentt ekkrdetrvm
      481 ifssfrdsvq eiaemlsqhq piirvmtfvg hasgkstkgf tqkeqlevvk qfrdggyntl
      541 vstcvgeegl digevdliic fdsqkspirl vqrmgrtgrk rqgriviils egreeriynq
      601 sqsnkrsiyk aissnrqvlh fyqrsprmvp dginpklhkm fithgvyepe kpsrnlqrks
      661 sifsyrdgmr qsslkkdwfl seeefklwnr lyrlrdsdei keitlpqvqf sslqneenkp
      721 aqesttgihq lslsewrlwq dhplpthqvd hsdrcrhfig lmqmiegmrh eegecsyele
      781 vesylqmedv tstfiaprne snnlasdtfi thkkssfikn inqgssssvi esdeecaeiv
      841 kqthikptki vslkkkvske ikkdqlkken nhgiidsvdn drnstvenif qedlpndkrt
      901 sdtdeiaatc tinenvikep cvlltecqft nkstsslagn vldsgynsfn deksvssnlf
      961 lpfeeelyiv rtddqfynch sltkevlanv erflsysppp lsglsdleye iakgtalenl
     1021 lflpcaehlr sdkctcllsh savnsqqnle lnslkcinyp seksclydip ndnisdepsl
     1081 cdcdvhkhnq nenlvpnnrv qihrspaqnl vgennhdvdn sdlpvlstdq deslllfedv
     1141 ntefddvsls plnskseslp vsdktaiset plvsqflisd ellldnnsel qdqitrdans
     1201 fksrdqrgvq eekvknhedi fdcsrdlfsv tfdlgfcspd sddeilehts dsnrplddly
     1261 gryleikeis danyvsnqal iprdhsknft sgtviipsne dmqnpnyvhl plsaakneel
     1321 lspgysqfsl pvqkkvmstp lsksntlnsf skirkeilkt pdsskekvnl qrfkealnst
     1381 fdysefslek skssgpmylh kschsvedgq lltsnesedd eifrrkvkra kgnvlnsped
     1441 qknsevdspl havkkrrfpi nrselsssde senfpkpcsq ledfkvcngn arrgikvpkr
     1501 qshlkhvark flddeaelse edaeyvssde ndeseneqds slldflndet qlsqaindse
     1561 mraiymkslr spmmnnkykm ihkthknini fsqipeqdet yledsfcvde eesckgqsse
     1621 eevcvdfnli tddcfanskk yktrravmlk emmeqncahs kkklsriilp ddsseeennv
     1681 ndkresniav npstvkknkq qdhclnsvps gssaqskvrs tprvnplakq skqtslnlkd
     1741 tisevsdfkp qnhnevqstt ppfttvdsqk dcrkfpvpqk ethqgclgeq ramtac
//
LOCUS       XP_047287590            1658 aa            linear   PRI 05-AUG-2025
DEFINITION  Fanconi anemia group M protein isoform X7 [Homo sapiens].
ACCESSION   XP_047287590
VERSION     XP_047287590.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431634.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1658
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1658
                     /product="Fanconi anemia group M protein isoform X7"
                     /calculated_mol_wt=188844
     Region          46..194
                     /region_name="SF2_C_FANCM_Hef"
                     /note="C-terminal helicase domain of Fanconi anemia group
                     M family helicases; cd18801"
                     /db_xref="CDD:350188"
     Site            order(181,184)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:350188"
     Region          280..395
                     /region_name="FANCM-MHF_bd"
                     /note="FANCM to MHF binding domain; pfam16783"
                     /db_xref="CDD:465270"
     Region          1115..>1198
                     /region_name="MRC1"
                     /note="MRC1-like domain; pfam09444"
                     /db_xref="CDD:430616"
     Region          1428..1566
                     /region_name="XPF_nuclease_FANCM"
                     /note="XPF-like nuclease domain of Fanconi anemia group M
                     protein (FANCM); cd20077"
                     /db_xref="CDD:410853"
     Site            order(1464,1474)
                     /site_type="other"
                     /note="Ca binding site [ion binding]"
                     /db_xref="CDD:410853"
     Site            order(1491,1494..1495,1498,1524,1526,1529..1530,
                     1532..1534,1536..1538,1540,1543..1544,1550,1553..1554,
                     1557..1558,1561)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:410853"
     CDS             1..1658
                     /gene="FANCM"
                     /gene_synonym="FAAP250; KIAA1596; POF15; SPGF28"
                     /coded_by="XM_047431634.1:90..5066"
                     /db_xref="GeneID:57697"
                     /db_xref="HGNC:HGNC:23168"
                     /db_xref="MIM:609644"
ORIGIN      
        1 mtrsknelgr nedfmklynh lecmfartrs tsangisaiq qgdknkkfvy shpklkklee
       61 vviehfkswn aenttekkrd etrvmifssf rdsvqeiaem lsqhqpiirv mtfvghasgk
      121 stkgftqkeq levvkqfrdg gyntlvstcv geegldigev dliicfdsqk spirlvqrmg
      181 rtgrkrqgri viilsegree riynqsqsnk rsiykaissn rqvlhfyqrs prmvpdginp
      241 klhkmfithg vyepekpsrn lqrkssifsy rdgmrqsslk kdwflseeef klwnrlyrlr
      301 dsdeikeitl pqvqfsslqn eenkpaqest tgihqlslse wrlwqdhplp thqvdhsdrc
      361 rhfiglmqmi egmrheegec syelevesyl qmedvtstfi aprnesnnla sdtfithkks
      421 sfikninqgs sssviesdee caeivkqthi kptkivslkk kvskeikkdq lkkennhgii
      481 dsvdndrnst venifqedlp ndkrtsdtde iaatctinen vikepcvllt ecqftnksts
      541 slagnvldsg ynsfndeksv ssnlflpfee elyivrtddq fynchsltke vlanverfls
      601 ysppplsgls dleyeiakgt alenllflpc aehlrsdkct cllshsavns qqnlelnslk
      661 cinypseksc lydipndnis depslcdcdv hkhnqnenlv pnnrvqihrs paqnlvgenn
      721 hdvdnsdlpv lstdqdesll lfedvntefd dvslsplnsk seslpvsdkt aisetplvsq
      781 flisdellld nnselqdqit rdansfksrd qrgvqeekvk nhedifdcsr dlfsvtfdlg
      841 fcspdsddei lehtsdsnrp lddlygryle ikeisdanyv snqaliprdh sknftsgtvi
      901 ipsnedmqnp nyvhlplsaa kneellspgy sqfslpvqkk vmstplsksn tlnsfskirk
      961 eilktpdssk ekvnlqrfke alnstfdyse fslekskssg pmylhkschs vedgqlltsn
     1021 eseddeifrr kvkrakgnvl nspedqknse vdsplhavkk rrfpinrvsk yqselsssde
     1081 senfpkpcsq ledfkvcngn arrgikvpkr qshlkhvark flddeaelse edaeyvssde
     1141 ndeseneqds slldflndet qlsqaindse mraiymkslr spmmnnkykm ihkthknini
     1201 fsqipeqdet yledsfcvde eesckgqsse eevcvdfnli tddcfanskk yktrravmlk
     1261 emmeqncahs kkklsriilp ddsseeennv ndkresniav npstvkknkq qdhclnsvps
     1321 gssaqskvrs tprvnplakq skqtslnlkd tisevsdfkp qnhnevqstt ppfttvdsqk
     1381 dcrkfpvpqk dgsaledsst sgascsksrp hlagthtslr lpqegkgtci lvggheitsg
     1441 levisslrai hglqvevcpl ngcdyivsnr mvverrsqse mlnsvnknkf ieqiqhlqsm
     1501 fericvivek drektgdtsr mfrrtksyds llttligagi rilfsscqee tadllkelsl
     1561 veqrknvgih vptvvnsnks ealqfylsip nisyitalnm chqfssvkrm ansslqeism
     1621 yaqvthqkae eiyryihyvf diqmlpndln qdrlksdi
//
LOCUS       XP_011535339            1391 aa            linear   PRI 05-AUG-2025
DEFINITION  Fanconi anemia group M protein isoform X8 [Homo sapiens].
ACCESSION   XP_011535339
VERSION     XP_011535339.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537037.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1391
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1391
                     /product="Fanconi anemia group M protein isoform X8"
                     /calculated_mol_wt=157884
     Region          13..128
                     /region_name="FANCM-MHF_bd"
                     /note="FANCM to MHF binding domain; pfam16783"
                     /db_xref="CDD:465270"
     Region          848..>931
                     /region_name="MRC1"
                     /note="MRC1-like domain; pfam09444"
                     /db_xref="CDD:430616"
     Region          1161..1299
                     /region_name="XPF_nuclease_FANCM"
                     /note="XPF-like nuclease domain of Fanconi anemia group M
                     protein (FANCM); cd20077"
                     /db_xref="CDD:410853"
     Site            order(1197,1207)
                     /site_type="other"
                     /note="Ca binding site [ion binding]"
                     /db_xref="CDD:410853"
     Site            order(1224,1227..1228,1231,1257,1259,1262..1263,
                     1265..1267,1269..1271,1273,1276..1277,1283,1286..1287,
                     1290..1291,1294)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:410853"
     CDS             1..1391
                     /gene="FANCM"
                     /gene_synonym="FAAP250; KIAA1596; POF15; SPGF28"
                     /coded_by="XM_011537037.4:560..4735"
                     /db_xref="GeneID:57697"
                     /db_xref="HGNC:HGNC:23168"
                     /db_xref="MIM:609644"
ORIGIN      
        1 mgtfrgmrqs slkkdwflse eefklwnrly rlrdsdeike itlpqvqfss lqneenkpaq
       61 esttgihqls lsewrlwqdh plpthqvdhs drcrhfiglm qmiegmrhee gecsyeleve
      121 sylqmedvts tfiaprnesn nlasdtfith kkssfiknin qgssssvies deecaeivkq
      181 thikptkivs lkkkvskeik kdqlkkennh giidsvdndr nstvenifqe dlpndkrtsd
      241 tdeiaatcti nenvikepcv lltecqftnk stsslagnvl dsgynsfnde ksvssnlflp
      301 feeelyivrt ddqfynchsl tkevlanver flsyspppls glsdleyeia kgtalenllf
      361 lpcaehlrsd kctcllshsa vnsqqnleln slkcinypse ksclydipnd nisdepslcd
      421 cdvhkhnqne nlvpnnrvqi hrspaqnlvg ennhdvdnsd lpvlstdqde slllfedvnt
      481 efddvslspl nskseslpvs dktaisetpl vsqflisdel lldnnselqd qitrdansfk
      541 srdqrgvqee kvknhedifd csrdlfsvtf dlgfcspdsd deilehtsds nrplddlygr
      601 yleikeisda nyvsnqalip rdhsknftsg tviipsnedm qnpnyvhlpl saakneells
      661 pgysqfslpv qkkvmstpls ksntlnsfsk irkeilktpd sskekvnlqr fkealnstfd
      721 ysefsleksk ssgpmylhks chsvedgqll tsneseddei frrkvkrakg nvlnspedqk
      781 nsevdsplha vkkrrfpinr vskyqselss sdesenfpkp csqledfkvc ngnarrgikv
      841 pkrqshlkhv arkflddeae lseedaeyvs sdendesene qdsslldfln detqlsqain
      901 dsemraiymk slrspmmnnk ykmihkthkn inifsqipeq detyledsfc vdeeesckgq
      961 sseeevcvdf nlitddcfan skkyktrrav mlkemmeqnc ahskkklsri ilpddsseee
     1021 nnvndkresn iavnpstvkk nkqqdhclns vpsgssaqsk vrstprvnpl akqskqtsln
     1081 lkdtisevsd fkpqnhnevq sttppfttvd sqkdcrkfpv pqkdgsaled sstsgascsk
     1141 srphlagtht slrlpqegkg tcilvgghei tsglevissl raihglqvev cplngcdyiv
     1201 snrmvverrs qsemlnsvnk nkfieqiqhl qsmfericvi vekdrektgd tsrmfrrtks
     1261 ydsllttlig agirilfssc qeetadllke lslveqrknv gihvptvvns nksealqfyl
     1321 sipnisyita lnmchqfssv krmansslqe ismyaqvthq kaeeiyryih yvfdiqmlpn
     1381 dlnqdrlksd i
//
LOCUS       XP_024305440             792 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform
            X1 [Homo sapiens].
ACCESSION   XP_024305440
VERSION     XP_024305440.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449672.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..792
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..792
                     /product="serine/threonine-protein phosphatase 4
                     regulatory subunit 4 isoform X1"
                     /calculated_mol_wt=90252
     Region          54..78
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Site            order(70..71,74,77..78,110..111,114,117..118,121,149..150,
                     153,156..157,160,188..189,192,195..196)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          92..121
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          131..161
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          132..207
                     /region_name="HEAT_2"
                     /note="HEAT repeats; pfam13646"
                     /db_xref="CDD:433376"
     Region          170..196
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          315..341
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          352..379
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     CDS             1..792
                     /gene="PPP4R4"
                     /gene_synonym="CFAP14; KIAA1622; PP4R4"
                     /coded_by="XM_024449672.2:282..2660"
                     /db_xref="GeneID:57718"
                     /db_xref="HGNC:HGNC:23788"
                     /db_xref="MIM:616790"
ORIGIN      
        1 mrqnptetlr rvlpkvreal hvagvemqlt aamsfltilq desvsihayt hsflqvillh
       61 lehrdtgvsn awletllsvi evlpketlrh eilnplvska qlsqtvqsrl vsckilgklt
      121 nkfdahtikr eilplvkslc qdveyevrsc mcrqleniaq gigteltksv vlpelielsr
      181 degssvrlaa fetlvnlldi fdtddrsqti lplvksfcek sfkadesili slsfhlgklc
      241 hglygiftpd qhlrflefyk klctlglqqe nghnenqipp qileqekkyi svrkncaynf
      301 pamivfvdpk nfhmelystf fclchdpevp vrytiaicfy evskllnsgv ylihkelitl
      361 lqdeslevld alidhlpeil elmstggess vqenklsslp dlipaltaae qraaaslkwr
      421 thekllqkya clphvissdq iyyrflqrmf timmtnnvlp vqkaasrtlc iflrynrkqe
      481 qrheviqkli eqlgqgksyw nrlrfldtce fiieifsksf fckyfflpai elthdpvanv
      541 rmklcyllpk vkstlkipad khllqqlemc vrkllcqekd kdvlaivkrt vleldrmems
      601 mdafqkkfye kdlldqeker eellllemeq lekekqqndg rpmsdkmfek krrdtktptq
      661 slpknipisv pgpssvtpst skeikkskli rsqsfnnqaf hakygnlekc askssttgyt
      721 tsvsglgkts vlsladdsfr trnassvpss fspntplpst srgtgnsvdp kssgskdtqp
      781 rkatlksrks np
//
LOCUS       XP_016877017             786 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform
            X2 [Homo sapiens].
ACCESSION   XP_016877017
VERSION     XP_016877017.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021528.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..786
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..786
                     /product="serine/threonine-protein phosphatase 4
                     regulatory subunit 4 isoform X2"
                     /calculated_mol_wt=89477
     Region          48..72
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Site            order(64..65,68,71..72,104..105,108,111..112,115,143..144,
                     147,150..151,154,182..183,186,189..190)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          86..115
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          125..155
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          126..201
                     /region_name="HEAT_2"
                     /note="HEAT repeats; pfam13646"
                     /db_xref="CDD:433376"
     Region          164..190
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          309..335
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          346..373
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     CDS             1..786
                     /gene="PPP4R4"
                     /gene_synonym="CFAP14; KIAA1622; PP4R4"
                     /coded_by="XM_017021528.3:97..2457"
                     /db_xref="GeneID:57718"
                     /db_xref="HGNC:HGNC:23788"
                     /db_xref="MIM:616790"
ORIGIN      
        1 mllresrlsn tealhvagve mqltaamsfl tilqdesvsi haythsflqv illhlehrdt
       61 gvsnawletl lsvievlpke tlrheilnpl vskaqlsqtv qsrlvsckil gkltnkfdah
      121 tikreilplv kslcqdveye vrscmcrqle niaqgigtel tksvvlpeli elsrdegssv
      181 rlaafetlvn lldifdtddr sqtilplvks fceksfkade silislsfhl gklchglygi
      241 ftpdqhlrfl efykklctlg lqqenghnen qippqileqe kkyisvrknc aynfpamivf
      301 vdpknfhmel ystffclchd pevpvrytia icfyevskll nsgvylihke litllqdesl
      361 evldalidhl peilelmstg gessvqenkl sslpdlipal taaeqraaas lkwrthekll
      421 qkyaclphvi ssdqiyyrfl qrmftimmtn nvlpvqkaas rtlciflryn rkqeqrhevi
      481 qklieqlgqg ksywnrlrfl dtcefiieif sksffckyff lpaielthdp vanvrmklcy
      541 llpkvkstlk ipadkhllqq lemcvrkllc qekdkdvlai vkrtvleldr memsmdafqk
      601 kfyekdlldq ekereellll emeqlekekq qndgrpmsdk mfekkrrdtk tptqslpkni
      661 pisvpgpssv tpstskeikk sklirsqsfn nqafhakygn lekcasksst tgyttsvsgl
      721 gktsvlslad dsfrtrnass vpssfspntp lpstsrgtgn svdpkssgsk dtqprkatlk
      781 srksnp
//
LOCUS       XP_011535341             766 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform
            X3 [Homo sapiens].
ACCESSION   XP_011535341
VERSION     XP_011535341.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537039.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..766
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..766
                     /product="serine/threonine-protein phosphatase 4
                     regulatory subunit 4 isoform X3"
                     /calculated_mol_wt=87269
     Region          28..52
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Site            order(44..45,48,51..52,84..85,88,91..92,95,123..124,127,
                     130..131,134,162..163,166,169..170)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          66..95
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          105..135
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          106..181
                     /region_name="HEAT_2"
                     /note="HEAT repeats; pfam13646"
                     /db_xref="CDD:433376"
     Region          144..170
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          289..315
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          326..353
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     CDS             1..766
                     /gene="PPP4R4"
                     /gene_synonym="CFAP14; KIAA1622; PP4R4"
                     /coded_by="XM_011537039.3:217..2517"
                     /db_xref="GeneID:57718"
                     /db_xref="HGNC:HGNC:23788"
                     /db_xref="MIM:616790"
ORIGIN      
        1 mqltaamsfl tilqdesvsi haythsflqv illhlehrdt gvsnawletl lsvievlpke
       61 tlrheilnpl vskaqlsqtv qsrlvsckil gkltnkfdah tikreilplv kslcqdveye
      121 vrscmcrqle niaqgigtel tksvvlpeli elsrdegssv rlaafetlvn lldifdtddr
      181 sqtilplvks fceksfkade silislsfhl gklchglygi ftpdqhlrfl efykklctlg
      241 lqqenghnen qippqileqe kkyisvrknc aynfpamivf vdpknfhmel ystffclchd
      301 pevpvrytia icfyevskll nsgvylihke litllqdesl evldalidhl peilelmstg
      361 gessvqenkl sslpdlipal taaeqraaas lkwrthekll qkyaclphvi ssdqiyyrfl
      421 qrmftimmtn nvlpvqkaas rtlciflryn rkqeqrhevi qklieqlgqg ksywnrlrfl
      481 dtcefiieif sksffckyff lpaielthdp vanvrmklcy llpkvkstlk ipadkhllqq
      541 lemcvrkllc qekdkdvlai vkrtvleldr memsmdafqk kfyekdlldq ekereellll
      601 emeqlekekq qndgrpmsdk mfekkrrdtk tptqslpkni pisvpgpssv tpstskeikk
      661 sklirsqsfn nqafhakygn lekcasksst tgyttsvsgl gktsvlslad dsfrtrnass
      721 vpssfspntp lpstsrgtgn svdpkssgsk dtqprkatlk srksnp
//
LOCUS       XP_024305441             766 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform
            X3 [Homo sapiens].
ACCESSION   XP_024305441
VERSION     XP_024305441.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449673.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..766
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..766
                     /product="serine/threonine-protein phosphatase 4
                     regulatory subunit 4 isoform X3"
                     /calculated_mol_wt=87269
     Region          28..52
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Site            order(44..45,48,51..52,84..85,88,91..92,95,123..124,127,
                     130..131,134,162..163,166,169..170)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          66..95
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          105..135
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          106..181
                     /region_name="HEAT_2"
                     /note="HEAT repeats; pfam13646"
                     /db_xref="CDD:433376"
     Region          144..170
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          289..315
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          326..353
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     CDS             1..766
                     /gene="PPP4R4"
                     /gene_synonym="CFAP14; KIAA1622; PP4R4"
                     /coded_by="XM_024449673.2:112..2412"
                     /db_xref="GeneID:57718"
                     /db_xref="HGNC:HGNC:23788"
                     /db_xref="MIM:616790"
ORIGIN      
        1 mqltaamsfl tilqdesvsi haythsflqv illhlehrdt gvsnawletl lsvievlpke
       61 tlrheilnpl vskaqlsqtv qsrlvsckil gkltnkfdah tikreilplv kslcqdveye
      121 vrscmcrqle niaqgigtel tksvvlpeli elsrdegssv rlaafetlvn lldifdtddr
      181 sqtilplvks fceksfkade silislsfhl gklchglygi ftpdqhlrfl efykklctlg
      241 lqqenghnen qippqileqe kkyisvrknc aynfpamivf vdpknfhmel ystffclchd
      301 pevpvrytia icfyevskll nsgvylihke litllqdesl evldalidhl peilelmstg
      361 gessvqenkl sslpdlipal taaeqraaas lkwrthekll qkyaclphvi ssdqiyyrfl
      421 qrmftimmtn nvlpvqkaas rtlciflryn rkqeqrhevi qklieqlgqg ksywnrlrfl
      481 dtcefiieif sksffckyff lpaielthdp vanvrmklcy llpkvkstlk ipadkhllqq
      541 lemcvrkllc qekdkdvlai vkrtvleldr memsmdafqk kfyekdlldq ekereellll
      601 emeqlekekq qndgrpmsdk mfekkrrdtk tptqslpkni pisvpgpssv tpstskeikk
      661 sklirsqsfn nqafhakygn lekcasksst tgyttsvsgl gktsvlslad dsfrtrnass
      721 vpssfspntp lpstsrgtgn svdpkssgsk dtqprkatlk srksnp
//
LOCUS       XP_011535342             766 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform
            X3 [Homo sapiens].
ACCESSION   XP_011535342
VERSION     XP_011535342.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537040.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..766
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..766
                     /product="serine/threonine-protein phosphatase 4
                     regulatory subunit 4 isoform X3"
                     /calculated_mol_wt=87269
     Region          28..52
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Site            order(44..45,48,51..52,84..85,88,91..92,95,123..124,127,
                     130..131,134,162..163,166,169..170)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          66..95
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          105..135
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          106..181
                     /region_name="HEAT_2"
                     /note="HEAT repeats; pfam13646"
                     /db_xref="CDD:433376"
     Region          144..170
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          289..315
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          326..353
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     CDS             1..766
                     /gene="PPP4R4"
                     /gene_synonym="CFAP14; KIAA1622; PP4R4"
                     /coded_by="XM_011537040.3:124..2424"
                     /db_xref="GeneID:57718"
                     /db_xref="HGNC:HGNC:23788"
                     /db_xref="MIM:616790"
ORIGIN      
        1 mqltaamsfl tilqdesvsi haythsflqv illhlehrdt gvsnawletl lsvievlpke
       61 tlrheilnpl vskaqlsqtv qsrlvsckil gkltnkfdah tikreilplv kslcqdveye
      121 vrscmcrqle niaqgigtel tksvvlpeli elsrdegssv rlaafetlvn lldifdtddr
      181 sqtilplvks fceksfkade silislsfhl gklchglygi ftpdqhlrfl efykklctlg
      241 lqqenghnen qippqileqe kkyisvrknc aynfpamivf vdpknfhmel ystffclchd
      301 pevpvrytia icfyevskll nsgvylihke litllqdesl evldalidhl peilelmstg
      361 gessvqenkl sslpdlipal taaeqraaas lkwrthekll qkyaclphvi ssdqiyyrfl
      421 qrmftimmtn nvlpvqkaas rtlciflryn rkqeqrhevi qklieqlgqg ksywnrlrfl
      481 dtcefiieif sksffckyff lpaielthdp vanvrmklcy llpkvkstlk ipadkhllqq
      541 lemcvrkllc qekdkdvlai vkrtvleldr memsmdafqk kfyekdlldq ekereellll
      601 emeqlekekq qndgrpmsdk mfekkrrdtk tptqslpkni pisvpgpssv tpstskeikk
      661 sklirsqsfn nqafhakygn lekcasksst tgyttsvsgl gktsvlslad dsfrtrnass
      721 vpssfspntp lpstsrgtgn svdpkssgsk dtqprkatlk srksnp
//
LOCUS       XP_047287595             474 aa            linear   PRI 05-AUG-2025
DEFINITION  lysosomal cobalamin transporter ABCD4 isoform X4 [Homo sapiens].
ACCESSION   XP_047287595
VERSION     XP_047287595.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431639.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..474
                     /product="lysosomal cobalamin transporter ABCD4 isoform
                     X4"
                     /calculated_mol_wt=53343
     Region          27..294
                     /region_name="ABC_membrane_2"
                     /note="ABC transporter transmembrane region 2; pfam06472"
                     /db_xref="CDD:399466"
     Region          <285..>436
                     /region_name="PLN03232"
                     /note="ABC transporter C family member; Provisional"
                     /db_xref="CDD:215640"
     Region          387..>453
                     /region_name="P-loop containing Nucleoside Triphosphate
                     Hydrolases"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; cl38936"
                     /db_xref="CDD:476819"
     Site            421..428
                     /site_type="other"
                     /note="Walker A/P-loop"
                     /db_xref="CDD:213190"
     CDS             1..474
                     /gene="ABCD4"
                     /gene_synonym="ABC41; EST352188; MAHCJ; P70R; P79R; PMP69;
                     PXMP1L"
                     /coded_by="XM_047431639.1:23..1447"
                     /db_xref="GeneID:5826"
                     /db_xref="HGNC:HGNC:68"
                     /db_xref="MIM:603214"
ORIGIN      
        1 mavagpapga garprldlqf lqrflqilkv lfpswssqna lmfltllclt lleqfviyqv
       61 glipsqyygv lgnkdlegfk tltflavmli vlnstlksfd qftcnllyvs wrkdltehlh
      121 rlyfrgrayy tlnvlrddid npdqrisqdv erfcrqlssm askliispft lvyytyqcfq
      181 stgwlgpvsi fgyfilgtvv nktlmgpivm klvhqekleg dfrfkhmqir vnaepaafyr
      241 aghvehmrtd rrlqrllqtq relmskelwl yigintfdyl gsilsyvvia ipifsgvygd
      301 lspaelstlv sknafvciyl iscftqlidl sttlsdvagy thrigqlret lldmslksqd
      361 ceilgesewg ldtppgwpaa epadtaflle rvsisapssd kplikdlslk isegqsllit
      421 gntgtgktsl lrvlgglwts trgdispegg lprlrrdahw dkesdaflhp plpl
//
LOCUS       XP_005267999             468 aa            linear   PRI 05-AUG-2025
DEFINITION  lysosomal cobalamin transporter ABCD4 isoform X5 [Homo sapiens].
ACCESSION   XP_005267999
VERSION     XP_005267999.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267942.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..468
                     /product="lysosomal cobalamin transporter ABCD4 isoform
                     X5"
                     /calculated_mol_wt=51813
     Region          <53..465
                     /region_name="YddA"
                     /note="ABC-type uncharacterized transport system, permease
                     and ATPase components [General function prediction only];
                     COG4178"
                     /db_xref="CDD:443337"
     CDS             1..468
                     /gene="ABCD4"
                     /gene_synonym="ABC41; EST352188; MAHCJ; P70R; P79R; PMP69;
                     PXMP1L"
                     /coded_by="XM_005267942.5:185..1591"
                     /db_xref="GeneID:5826"
                     /db_xref="HGNC:HGNC:68"
                     /db_xref="MIM:603214"
ORIGIN      
        1 mtsitrtsas artwsdsags saawpassss prspssttlt saskgwlgpv sifgyfilgt
       61 vvnktlmgpi vmklvhqekl egdfrfkhmq irvnaepaaf yraghvehmr tdrrlqrllq
      121 tqrelmskel wlyigintfd ylgsilsyvv iaipifsgvy gdlspaelst lvsknafvci
      181 yliscftqli dlsttlsdva gythrigqlr etlldmslks qdceilgese wgldtppgwp
      241 aaepadtafl lervsisaps sdkplikdls lkisegqsll itgntgtgkt sllrvlgglw
      301 tstrgsvqml tdfgphgvlf lpqkpfftdg tlreqviypl kevypdsgsa dderilrfle
      361 laglsnlvar tegldqqvdw nwydvlspge mqrlsfarlf ylqpkyavld eatsalteev
      421 eselyrigqq lgmtfisvgh rqslekfhsl vlklcgggrw elmrikve
//
LOCUS       XP_047287596             458 aa            linear   PRI 05-AUG-2025
DEFINITION  lysosomal cobalamin transporter ABCD4 isoform X6 [Homo sapiens].
ACCESSION   XP_047287596
VERSION     XP_047287596.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431640.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..458
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..458
                     /product="lysosomal cobalamin transporter ABCD4 isoform
                     X6"
                     /calculated_mol_wt=51523
     Region          27..294
                     /region_name="ABC_membrane_2"
                     /note="ABC transporter transmembrane region 2; pfam06472"
                     /db_xref="CDD:399466"
     Region          <285..>436
                     /region_name="PLN03232"
                     /note="ABC transporter C family member; Provisional"
                     /db_xref="CDD:215640"
     Region          387..>453
                     /region_name="P-loop containing Nucleoside Triphosphate
                     Hydrolases"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; cl38936"
                     /db_xref="CDD:476819"
     Site            421..428
                     /site_type="other"
                     /note="Walker A/P-loop"
                     /db_xref="CDD:213190"
     CDS             1..458
                     /gene="ABCD4"
                     /gene_synonym="ABC41; EST352188; MAHCJ; P70R; P79R; PMP69;
                     PXMP1L"
                     /coded_by="XM_047431640.1:23..1399"
                     /db_xref="GeneID:5826"
                     /db_xref="HGNC:HGNC:68"
                     /db_xref="MIM:603214"
ORIGIN      
        1 mavagpapga garprldlqf lqrflqilkv lfpswssqna lmfltllclt lleqfviyqv
       61 glipsqyygv lgnkdlegfk tltflavmli vlnstlksfd qftcnllyvs wrkdltehlh
      121 rlyfrgrayy tlnvlrddid npdqrisqdv erfcrqlssm askliispft lvyytyqcfq
      181 stgwlgpvsi fgyfilgtvv nktlmgpivm klvhqekleg dfrfkhmqir vnaepaafyr
      241 aghvehmrtd rrlqrllqtq relmskelwl yigintfdyl gsilsyvvia ipifsgvygd
      301 lspaelstlv sknafvciyl iscftqlidl sttlsdvagy thrigqlret lldmslksqd
      361 ceilgesewg ldtppgwpaa epadtaflle rvsisapssd kplikdlslk isegqsllit
      421 gntgtgktsl lrvlgglwts trgdispegg lprlrfcr
//
LOCUS       XP_011535346             843 aa            linear   PRI 05-AUG-2025
DEFINITION  RNA-binding protein 25 isoform X1 [Homo sapiens].
ACCESSION   XP_011535346
VERSION     XP_011535346.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537044.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..843
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..843
                     /product="RNA-binding protein 25 isoform X1"
                     /calculated_mol_wt=100055
     Region          87..169
                     /region_name="RRM_RBM25"
                     /note="RNA recognition motif (RRM) found in eukaryotic
                     RNA-binding protein 25 and similar proteins; cd12446"
                     /db_xref="CDD:409880"
     Region          763..836
                     /region_name="PWI"
                     /note="domain in splicing factors; smart00311"
                     /db_xref="CDD:214609"
     CDS             1..843
                     /gene="RBM25"
                     /gene_synonym="fSAP94; NET52; RED120; RNPC7; S164; Snu71"
                     /coded_by="XM_011537044.4:310..2841"
                     /db_xref="GeneID:58517"
                     /db_xref="HGNC:HGNC:23244"
                     /db_xref="MIM:612427"
ORIGIN      
        1 msfpphlnrp pmgipalppg ipppqfpgfp ppvppgtpmi pvpmsimapa ptvlvptvsm
       61 vgkhlgarkd hpglkakend encgptttvf vgnisekasd mlirqllakc glvlswkrvq
      121 gasgklqafg fceykepest lralrllhdl qigekkllvk vdaktkaqld ewkakkkasn
      181 gnarpetvtn ddeealdeet krrdqmikga ievlireyss elnapsqesd shprkkkkek
      241 kedifrrfpv aplipyplit kedinaieme edkrdlisre iskfrdthkk leeekgkkek
      301 erqeiekerr ererererer errererere rererekeke rerererdrd rdrtkerdrd
      361 rdrerdrdrd rerssdrnkd rsrsreksrd rerererere rerererere rerererere
      421 rererekdkk rdreedeeda yerrklerkl rekeaayqer lknweirerk ktreyekeae
      481 reeerrrema keakrlkefl edydddrddp kyyrgsalqk rlrdrekeme aderdrkrek
      541 eeleeirqrl laeghpdpda elqrmeqeae rrrqpqikqe peseeeeeek qekeekreep
      601 meeeeepeqk pclkptlrpi ssapsvssas gnatpntpgd espcgiiiph enspdqqqpe
      661 ehrpkiglsl klgasnspgq pnsvkrkklp vdsvfnkfed edsddvprkr klvpldyged
      721 dknatkgtvn teekrkhiks liekiptakp elfaypldws ivdsilmerr irpwinkkii
      781 eyigeeeatl vdfvcskvma hsspqsildd vamvldeeae vfivkmwrll iyeteakkig
      841 lvk
//
LOCUS       XP_047287597             710 aa            linear   PRI 05-AUG-2025
DEFINITION  RNA-binding protein 25 isoform X2 [Homo sapiens].
ACCESSION   XP_047287597
VERSION     XP_047287597.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431641.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..710
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..710
                     /product="RNA-binding protein 25 isoform X2"
                     /calculated_mol_wt=84936
     Region          87..169
                     /region_name="RRM_RBM25"
                     /note="RNA recognition motif (RRM) found in eukaryotic
                     RNA-binding protein 25 and similar proteins; cd12446"
                     /db_xref="CDD:409880"
     CDS             1..710
                     /gene="RBM25"
                     /gene_synonym="fSAP94; NET52; RED120; RNPC7; S164; Snu71"
                     /coded_by="XM_047431641.1:188..2320"
                     /db_xref="GeneID:58517"
                     /db_xref="HGNC:HGNC:23244"
                     /db_xref="MIM:612427"
ORIGIN      
        1 msfpphlnrp pmgipalppg ipppqfpgfp ppvppgtpmi pvpmsimapa ptvlvptvsm
       61 vgkhlgarkd hpglkakend encgptttvf vgnisekasd mlirqllakc glvlswkrvq
      121 gasgklqafg fceykepest lralrllhdl qigekkllvk vdaktkaqld ewkakkkasn
      181 gnarpetvtn ddeealdeet krrdqmikga ievlireyss elnapsqesd shprkkkkek
      241 kedifrrfpv aplipyplit kedinaieme edkrdlisre iskfrdthkk leeekgkkek
      301 erqeiekerr ererererer errererere rererekeke rerererdrd rdrtkerdrd
      361 rdrerdrdrd rerssdrnkd rsrsreksrd rerererere rerererere rerererere
      421 rererekdkk rdreedeeda yerrklerkl rekeaayqer lknweirerk ktreyekeae
      481 reeerrrema keakrlkefl edydddrddp kyyrgsalqk rlrdrekeme aderdrkrek
      541 eeleeirqrl laeghpdpda elqrmeqeae rrrqpqikqe peseeeeeek qekeekreep
      601 meeeeepeqk pclkptlrpi ssapsvssas gnatpntpgd espcgiiiph enspdqqqpe
      661 ehrpkiglsl klvllvllyl qlprvlrrse kfnflalvss elfftvgifl
//
LOCUS       XP_047287598             266 aa            linear   PRI 05-AUG-2025
DEFINITION  sorting nexin-6 isoform X1 [Homo sapiens].
ACCESSION   XP_047287598
VERSION     XP_047287598.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431642.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..266
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..266
                     /product="sorting nexin-6 isoform X1"
                     /calculated_mol_wt=30394
     Region          30..170
                     /region_name="PX_SNX6"
                     /note="The phosphoinositide binding Phox Homology domain
                     of Sorting Nexin 6; cd07292"
                     /db_xref="CDD:132825"
     Site            order(69..71,96..97,140)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:132825"
     Region          186..>265
                     /region_name="BAR"
                     /note="The Bin/Amphiphysin/Rvs (BAR) domain, a
                     dimerization module that binds membranes and detects
                     membrane curvature; cl12013"
                     /db_xref="CDD:472257"
     CDS             1..266
                     /gene="SNX6"
                     /gene_synonym="MSTP010; TFAF2"
                     /coded_by="XM_047431642.1:33..833"
                     /db_xref="GeneID:58533"
                     /db_xref="HGNC:HGNC:14970"
                     /db_xref="MIM:606098"
ORIGIN      
        1 mmeglddgpd flseedrglk ainvdlqsda alqvdisdal serdkvkftv htksslpnfk
       61 qnefsvvrqh eefiwlhdsf venedyagyi ippapprpdf dasreklqkl gegegsmtke
      121 eftkmkqele aeylaifkkt vamhevflcr vaahpilrrd lnfhvfleyn qdlsvrgknk
      181 kekledffkn mvksadgviv sgvkdvddff ehertflley hnrvkdasak sdrmtrshks
      241 aaddynrigs slyalgtqds tdickk
//
LOCUS       XP_047287599             387 aa            linear   PRI 05-AUG-2025
DEFINITION  MAPK/MAK/MRK overlapping kinase isoform X1 [Homo sapiens].
ACCESSION   XP_047287599
VERSION     XP_047287599.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431643.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..387
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..387
                     /product="MAPK/MAK/MRK overlapping kinase isoform X1"
                     /calculated_mol_wt=44227
     Region          4..285
                     /region_name="STKc_MOK"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     MAPK/MAK/MRK Overlapping Kinase; cd07831"
                     /db_xref="CDD:270825"
     Site            order(10..14,18,31,33,49,64,82..85,88,90..91,128,130,
                     132..133,135,145,148,159,161..164,166,204)
                     /site_type="active"
                     /db_xref="CDD:270825"
     Site            order(10..14,18,31,33,64,82..85,88,128,130,132..133,135,
                     145)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270825"
     Site            order(49,90,128,130,148,159,161..164,166,204)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270825"
     Site            144..166
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270825"
     CDS             1..387
                     /gene="MOK"
                     /gene_synonym="RAGE; RAGE-1; RAGE1; STK30"
                     /coded_by="XM_047431643.1:197..1360"
                     /db_xref="GeneID:5891"
                     /db_xref="HGNC:HGNC:9833"
                     /db_xref="MIM:605762"
ORIGIN      
        1 mknykaigki gegtfsevmk mqslrdgnyy ackqmkqrfe sieqvnnlre iqalrrlnph
       61 pnilmlhevv fdrksgslal icelmdmniy elirgrrypl sekkimhymy qlcksldhih
      121 rngifhrdvk penilikqdv lklgdfgscr svyskqpyte yistrwyrap eclltdgfyt
      181 ykmdlwsagc vfyeiaslqp lfpgvneldq iskihdvigt paqkiltkfk qsramnfdfp
      241 fkkgsgipll ttnlspqcls llhamvaydp deriaahqal qhpyfqeqrk tekralgshr
      301 kagfpehpva peplsnscqi skegrkqvpg smpkhradia pqngpggrrq edamlaqvth
      361 pasdrsqvtv sawlqmstss hqqrnsp
//
LOCUS       XP_006720289             292 aa            linear   PRI 05-AUG-2025
DEFINITION  MAPK/MAK/MRK overlapping kinase isoform X2 [Homo sapiens].
ACCESSION   XP_006720289
VERSION     XP_006720289.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720226.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..292
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..292
                     /product="MAPK/MAK/MRK overlapping kinase isoform X2"
                     /calculated_mol_wt=33870
     Region          4..285
                     /region_name="STKc_MOK"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     MAPK/MAK/MRK Overlapping Kinase; cd07831"
                     /db_xref="CDD:270825"
     Site            order(10..14,18,31,33,49,64,82..85,88,90..91,128,130,
                     132..133,135,145,148,159,161..164,166,204)
                     /site_type="active"
                     /db_xref="CDD:270825"
     Site            order(10..14,18,31,33,64,82..85,88,128,130,132..133,135,
                     145)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270825"
     Site            order(49,90,128,130,148,159,161..164,166,204)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270825"
     Site            144..166
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270825"
     CDS             1..292
                     /gene="MOK"
                     /gene_synonym="RAGE; RAGE-1; RAGE1; STK30"
                     /coded_by="XM_006720226.4:197..1075"
                     /db_xref="GeneID:5891"
                     /db_xref="HGNC:HGNC:9833"
                     /db_xref="MIM:605762"
ORIGIN      
        1 mknykaigki gegtfsevmk mqslrdgnyy ackqmkqrfe sieqvnnlre iqalrrlnph
       61 pnilmlhevv fdrksgslal icelmdmniy elirgrrypl sekkimhymy qlcksldhih
      121 rngifhrdvk penilikqdv lklgdfgscr svyskqpyte yistrwyrap eclltdgfyt
      181 ykmdlwsagc vfyeiaslqp lfpgvneldq iskihdvigt paqkiltkfk qsramnfdfp
      241 fkkgsgipll ttnlspqcls llhamvaydp deriaahqal qhpyfqeqrn sp
//
LOCUS       XP_047287600             291 aa            linear   PRI 05-AUG-2025
DEFINITION  MAPK/MAK/MRK overlapping kinase isoform X3 [Homo sapiens].
ACCESSION   XP_047287600
VERSION     XP_047287600.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431644.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..291
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..291
                     /product="MAPK/MAK/MRK overlapping kinase isoform X3"
                     /calculated_mol_wt=33742
     Region          4..284
                     /region_name="STKc_MOK"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     MAPK/MAK/MRK Overlapping Kinase; cd07831"
                     /db_xref="CDD:270825"
     Site            order(10..14,18,31,33,49,64,82..85,88,90..91,128,130,
                     132..133,135,144,147,158,160..163,165,203)
                     /site_type="active"
                     /db_xref="CDD:270825"
     Site            order(10..14,18,31,33,64,82..85,88,128,130,132..133,135,
                     144)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270825"
     Site            order(49,90,128,130,147,158,160..163,165,203)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270825"
     Site            143..165
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270825"
     CDS             1..291
                     /gene="MOK"
                     /gene_synonym="RAGE; RAGE-1; RAGE1; STK30"
                     /coded_by="XM_047431644.1:197..1072"
                     /db_xref="GeneID:5891"
                     /db_xref="HGNC:HGNC:9833"
                     /db_xref="MIM:605762"
ORIGIN      
        1 mknykaigki gegtfsevmk mqslrdgnyy ackqmkqrfe sieqvnnlre iqalrrlnph
       61 pnilmlhevv fdrksgslal icelmdmniy elirgrrypl sekkimhymy qlcksldhih
      121 rngifhrdvk penilikdvl klgdfgscrs vyskqpytey istrwyrape clltdgfyty
      181 kmdlwsagcv fyeiaslqpl fpgvneldqi skihdvigtp aqkiltkfkq sramnfdfpf
      241 kkgsgipllt tnlspqclsl lhamvaydpd eriaahqalq hpyfqeqrns p
//
LOCUS       XP_016877045             271 aa            linear   PRI 05-AUG-2025
DEFINITION  MAPK/MAK/MRK overlapping kinase isoform X4 [Homo sapiens].
ACCESSION   XP_016877045
VERSION     XP_016877045.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021556.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..271
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..271
                     /product="MAPK/MAK/MRK overlapping kinase isoform X4"
                     /calculated_mol_wt=31183
     Region          4..231
                     /region_name="STKc_MOK"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     MAPK/MAK/MRK Overlapping Kinase; cd07831"
                     /db_xref="CDD:270825"
     Site            order(10..14,18,31,33,49,64,82..85,88,90..91,128,130,
                     132..133,135,145,148,159,161..164,166,204)
                     /site_type="active"
                     /db_xref="CDD:270825"
     Site            order(10..14,18,31,33,64,82..85,88,128,130,132..133,135,
                     145)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270825"
     Site            order(49,90,128,130,148,159,161..164,166,204)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270825"
     Site            144..166
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270825"
     CDS             1..271
                     /gene="MOK"
                     /gene_synonym="RAGE; RAGE-1; RAGE1; STK30"
                     /coded_by="XM_017021556.3:197..1012"
                     /db_xref="GeneID:5891"
                     /db_xref="HGNC:HGNC:9833"
                     /db_xref="MIM:605762"
ORIGIN      
        1 mknykaigki gegtfsevmk mqslrdgnyy ackqmkqrfe sieqvnnlre iqalrrlnph
       61 pnilmlhevv fdrksgslal icelmdmniy elirgrrypl sekkimhymy qlcksldhih
      121 rngifhrdvk penilikqdv lklgdfgscr svyskqpyte yistrwyrap eclltdgfyt
      181 ykmdlwsagc vfyeiaslqp lfpgvneldq iskihdvigt paqkiltkfk qtqngsedea
      241 savllpiqtr sslnpllstc mlpgrsvtll v
//
LOCUS       XP_047287601             268 aa            linear   PRI 05-AUG-2025
DEFINITION  MAPK/MAK/MRK overlapping kinase isoform X5 [Homo sapiens].
ACCESSION   XP_047287601
VERSION     XP_047287601.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431645.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..268
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..268
                     /product="MAPK/MAK/MRK overlapping kinase isoform X5"
                     /calculated_mol_wt=30036
     Region          <47..134
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..268
                     /gene="MOK"
                     /gene_synonym="RAGE; RAGE-1; RAGE1; STK30"
                     /coded_by="XM_047431645.1:1359..2165"
                     /db_xref="GeneID:5891"
                     /db_xref="HGNC:HGNC:9833"
                     /db_xref="MIM:605762"
ORIGIN      
        1 mweclivivi pavrvtirqt akvretfgwy snwkelhyii plqtiglqpl fpgvneldqi
       61 skihdvigtp aqkiltkfkq sramnfdfpf kkgsgipllt tnlspqclsl lhamvaydpd
      121 eriaahqalq hpyfqeqrkt ekralgshrk agfpehpvap eplsnscqis kegrkqkqsl
      181 kqeedrpkrr gpayvmelpk lklsgvvrls syssptlqsv lgsgtngrvp vlrplkcipa
      241 skktdpqkdl kpapqqcrlp tivrkggr
//
LOCUS       XP_047287602             263 aa            linear   PRI 05-AUG-2025
DEFINITION  MAPK/MAK/MRK overlapping kinase isoform X6 [Homo sapiens].
ACCESSION   XP_047287602
VERSION     XP_047287602.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431646.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..263
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..263
                     /product="MAPK/MAK/MRK overlapping kinase isoform X6"
                     /calculated_mol_wt=30450
     Region          4..255
                     /region_name="STKc_MOK"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     MAPK/MAK/MRK Overlapping Kinase; cd07831"
                     /db_xref="CDD:270825"
     Site            order(10..14,18,31,33,52..55,58,60..61,98,100,102..103,
                     105,115,118,129,131..134,136,174)
                     /site_type="active"
                     /db_xref="CDD:270825"
     Site            order(10..14,18,31,33,52..55,58,98,100,102..103,105,115)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270825"
     Site            order(60,98,100,118,129,131..134,136,174)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270825"
     Site            114..136
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270825"
     CDS             1..263
                     /gene="MOK"
                     /gene_synonym="RAGE; RAGE-1; RAGE1; STK30"
                     /coded_by="XM_047431646.1:197..988"
                     /db_xref="GeneID:5891"
                     /db_xref="HGNC:HGNC:9833"
                     /db_xref="MIM:605762"
ORIGIN      
        1 mknykaigki gegtfsevmk mqslrdgnyy ackqmkqrfe sdrksgslal icelmdmniy
       61 elirgrrypl sekkimhymy qlcksldhih rngifhrdvk penilikqdv lklgdfgscr
      121 svyskqpyte yistrwyrap eclltdgfyt ykmdlwsagc vfyeiaslqp lfpgvneldq
      181 iskihdvigt paqkiltkfk qsramnfdfp fkkgsgipll ttnlspqcls llhamvaydp
      241 deriaahqal qhpyfqeqrr ltp
//
LOCUS       XP_016877046             262 aa            linear   PRI 05-AUG-2025
DEFINITION  MAPK/MAK/MRK overlapping kinase isoform X7 [Homo sapiens].
ACCESSION   XP_016877046
VERSION     XP_016877046.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021557.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..262
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..262
                     /product="MAPK/MAK/MRK overlapping kinase isoform X7"
                     /calculated_mol_wt=30281
     Region          4..255
                     /region_name="STKc_MOK"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     MAPK/MAK/MRK Overlapping Kinase; cd07831"
                     /db_xref="CDD:270825"
     Site            order(10..14,18,31,33,52..55,58,60..61,98,100,102..103,
                     105,115,118,129,131..134,136,174)
                     /site_type="active"
                     /db_xref="CDD:270825"
     Site            order(10..14,18,31,33,52..55,58,98,100,102..103,105,115)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270825"
     Site            order(60,98,100,118,129,131..134,136,174)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270825"
     Site            114..136
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270825"
     CDS             1..262
                     /gene="MOK"
                     /gene_synonym="RAGE; RAGE-1; RAGE1; STK30"
                     /coded_by="XM_017021557.3:197..985"
                     /db_xref="GeneID:5891"
                     /db_xref="HGNC:HGNC:9833"
                     /db_xref="MIM:605762"
ORIGIN      
        1 mknykaigki gegtfsevmk mqslrdgnyy ackqmkqrfe sdrksgslal icelmdmniy
       61 elirgrrypl sekkimhymy qlcksldhih rngifhrdvk penilikqdv lklgdfgscr
      121 svyskqpyte yistrwyrap eclltdgfyt ykmdlwsagc vfyeiaslqp lfpgvneldq
      181 iskihdvigt paqkiltkfk qsramnfdfp fkkgsgipll ttnlspqcls llhamvaydp
      241 deriaahqal qhpyfqeqrn sp
//
LOCUS       XP_047287603             262 aa            linear   PRI 05-AUG-2025
DEFINITION  MAPK/MAK/MRK overlapping kinase isoform X8 [Homo sapiens].
ACCESSION   XP_047287603
VERSION     XP_047287603.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431647.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..262
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..262
                     /product="MAPK/MAK/MRK overlapping kinase isoform X8"
                     /calculated_mol_wt=30322
     Region          4..254
                     /region_name="STKc_MOK"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     MAPK/MAK/MRK Overlapping Kinase; cd07831"
                     /db_xref="CDD:270825"
     Site            order(10..14,18,31,33,52..55,58,60..61,98,100,102..103,
                     105,114,117,128,130..133,135,173)
                     /site_type="active"
                     /db_xref="CDD:270825"
     Site            order(10..14,18,31,33,52..55,58,98,100,102..103,105,114)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270825"
     Site            order(60,98,100,117,128,130..133,135,173)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270825"
     Site            113..135
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270825"
     CDS             1..262
                     /gene="MOK"
                     /gene_synonym="RAGE; RAGE-1; RAGE1; STK30"
                     /coded_by="XM_047431647.1:197..985"
                     /db_xref="GeneID:5891"
                     /db_xref="HGNC:HGNC:9833"
                     /db_xref="MIM:605762"
ORIGIN      
        1 mknykaigki gegtfsevmk mqslrdgnyy ackqmkqrfe sdrksgslal icelmdmniy
       61 elirgrrypl sekkimhymy qlcksldhih rngifhrdvk penilikdvl klgdfgscrs
      121 vyskqpytey istrwyrape clltdgfyty kmdlwsagcv fyeiaslqpl fpgvneldqi
      181 skihdvigtp aqkiltkfkq sramnfdfpf kkgsgipllt tnlspqclsl lhamvaydpd
      241 eriaahqalq hpyfqeqrrl tp
//
LOCUS       XP_016877047             261 aa            linear   PRI 05-AUG-2025
DEFINITION  MAPK/MAK/MRK overlapping kinase isoform X9 [Homo sapiens].
ACCESSION   XP_016877047
VERSION     XP_016877047.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021558.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..261
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..261
                     /product="MAPK/MAK/MRK overlapping kinase isoform X9"
                     /calculated_mol_wt=30153
     Region          4..254
                     /region_name="STKc_MOK"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     MAPK/MAK/MRK Overlapping Kinase; cd07831"
                     /db_xref="CDD:270825"
     Site            order(10..14,18,31,33,52..55,58,60..61,98,100,102..103,
                     105,114,117,128,130..133,135,173)
                     /site_type="active"
                     /db_xref="CDD:270825"
     Site            order(10..14,18,31,33,52..55,58,98,100,102..103,105,114)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270825"
     Site            order(60,98,100,117,128,130..133,135,173)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270825"
     Site            113..135
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270825"
     CDS             1..261
                     /gene="MOK"
                     /gene_synonym="RAGE; RAGE-1; RAGE1; STK30"
                     /coded_by="XM_017021558.2:197..982"
                     /db_xref="GeneID:5891"
                     /db_xref="HGNC:HGNC:9833"
                     /db_xref="MIM:605762"
ORIGIN      
        1 mknykaigki gegtfsevmk mqslrdgnyy ackqmkqrfe sdrksgslal icelmdmniy
       61 elirgrrypl sekkimhymy qlcksldhih rngifhrdvk penilikdvl klgdfgscrs
      121 vyskqpytey istrwyrape clltdgfyty kmdlwsagcv fyeiaslqpl fpgvneldqi
      181 skihdvigtp aqkiltkfkq sramnfdfpf kkgsgipllt tnlspqclsl lhamvaydpd
      241 eriaahqalq hpyfqeqrns p
//
LOCUS       XP_047287604             237 aa            linear   PRI 05-AUG-2025
DEFINITION  MAPK/MAK/MRK overlapping kinase isoform X10 [Homo sapiens].
ACCESSION   XP_047287604
VERSION     XP_047287604.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431648.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..237
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..237
                     /product="MAPK/MAK/MRK overlapping kinase isoform X10"
                     /calculated_mol_wt=27800
     Region          4..231
                     /region_name="STKc_MOK"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     MAPK/MAK/MRK Overlapping Kinase; cd07831"
                     /db_xref="CDD:270825"
     Site            order(10..14,18,31,33,49,64,82..85,88,90..91,128,130,
                     132..133,135,145,148,159,161..164,166,204)
                     /site_type="active"
                     /db_xref="CDD:270825"
     Site            order(10..14,18,31,33,64,82..85,88,128,130,132..133,135,
                     145)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270825"
     Site            order(49,90,128,130,148,159,161..164,166,204)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270825"
     Site            144..166
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270825"
     CDS             1..237
                     /gene="MOK"
                     /gene_synonym="RAGE; RAGE-1; RAGE1; STK30"
                     /coded_by="XM_047431648.1:197..910"
                     /db_xref="GeneID:5891"
                     /db_xref="HGNC:HGNC:9833"
                     /db_xref="MIM:605762"
ORIGIN      
        1 mknykaigki gegtfsevmk mqslrdgnyy ackqmkqrfe sieqvnnlre iqalrrlnph
       61 pnilmlhevv fdrksgslal icelmdmniy elirgrrypl sekkimhymy qlcksldhih
      121 rngifhrdvk penilikqdv lklgdfgscr svyskqpyte yistrwyrap eclltdgfyt
      181 ykmdlwsagc vfyeiaslqp lfpgvneldq iskihdvigt paqkiltkfk qdqeyly
//
LOCUS       XP_047287605             236 aa            linear   PRI 05-AUG-2025
DEFINITION  MAPK/MAK/MRK overlapping kinase isoform X11 [Homo sapiens].
ACCESSION   XP_047287605
VERSION     XP_047287605.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431649.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..236
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..236
                     /product="MAPK/MAK/MRK overlapping kinase isoform X11"
                     /calculated_mol_wt=27672
     Region          4..230
                     /region_name="STKc_MOK"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     MAPK/MAK/MRK Overlapping Kinase; cd07831"
                     /db_xref="CDD:270825"
     Site            order(10..14,18,31,33,49,64,82..85,88,90..91,128,130,
                     132..133,135,144,147,158,160..163,165,203)
                     /site_type="active"
                     /db_xref="CDD:270825"
     Site            order(10..14,18,31,33,64,82..85,88,128,130,132..133,135,
                     144)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270825"
     Site            order(49,90,128,130,147,158,160..163,165,203)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270825"
     Site            143..165
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270825"
     CDS             1..236
                     /gene="MOK"
                     /gene_synonym="RAGE; RAGE-1; RAGE1; STK30"
                     /coded_by="XM_047431649.1:197..907"
                     /db_xref="GeneID:5891"
                     /db_xref="HGNC:HGNC:9833"
                     /db_xref="MIM:605762"
ORIGIN      
        1 mknykaigki gegtfsevmk mqslrdgnyy ackqmkqrfe sieqvnnlre iqalrrlnph
       61 pnilmlhevv fdrksgslal icelmdmniy elirgrrypl sekkimhymy qlcksldhih
      121 rngifhrdvk penilikdvl klgdfgscrs vyskqpytey istrwyrape clltdgfyty
      181 kmdlwsagcv fyeiaslqpl fpgvneldqi skihdvigtp aqkiltkfkq dqeyly
//
LOCUS       XP_047287606             185 aa            linear   PRI 05-AUG-2025
DEFINITION  MAPK/MAK/MRK overlapping kinase isoform X12 [Homo sapiens].
ACCESSION   XP_047287606
VERSION     XP_047287606.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431650.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..185
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..185
                     /product="MAPK/MAK/MRK overlapping kinase isoform X12"
                     /calculated_mol_wt=20467
     Region          <1..51
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..185
                     /gene="MOK"
                     /gene_synonym="RAGE; RAGE-1; RAGE1; STK30"
                     /coded_by="XM_047431650.1:1989..2546"
                     /db_xref="GeneID:5891"
                     /db_xref="HGNC:HGNC:9833"
                     /db_xref="MIM:605762"
ORIGIN      
        1 mnfdfpfkkg sgipllttnl spqclsllha mvaydpderi aahqalqhpy fqeqrktekr
       61 algshrkagf pehpvapepl snscqiskeg rkqkqslkqe edrpkrrgpa yvmelpklkl
      121 sgvvrlssys sptlqsvlgs gtngrvpvlr plkcipaskk tdpqkdlkpa pqqcrlptiv
      181 rkggr
//
LOCUS       XP_005268021            1277 aa            linear   PRI 05-AUG-2025
DEFINITION  AT-rich interactive domain-containing protein 4A isoform X1 [Homo
            sapiens].
ACCESSION   XP_005268021
VERSION     XP_005268021.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267964.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1277
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1277
                     /product="AT-rich interactive domain-containing protein 4A
                     isoform X1"
                     /calculated_mol_wt=144679
     Region          4..61
                     /region_name="Tudor_ARID4A_rpt1"
                     /note="first Tudor domain found in AT-rich interactive
                     domain-containing protein 4A (ARID4A) and similar
                     proteins; cd20459"
                     /db_xref="CDD:410530"
     Site            order(20,23,25,42,45,47)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410530"
     Region          62..114
                     /region_name="Tudor_ARID4_rpt2"
                     /note="second Tudor domain found in AT-rich interactive
                     domain-containing protein ARID4 family; cd20390"
                     /db_xref="CDD:410461"
     Site            order(70,74,76,93,95,97)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410461"
     Region          170..262
                     /region_name="RBB1NT"
                     /note="RBB1NT (NUC162) domain; pfam08169"
                     /db_xref="CDD:462390"
     Region          311..397
                     /region_name="ARID_ARID4A"
                     /note="ARID/BRIGHT DNA binding domain of AT-rich
                     interactive domain-containing protein 4A (ARID4A) and
                     similar proteins; cd16882"
                     /db_xref="CDD:350646"
     Site            order(332..338,363,365..366,369,380,382..384,386)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:350646"
     Region          577..635
                     /region_name="CBD_RBP1_like"
                     /note="chromo barrel domain of retinoblastoma binding
                     protein 1, and similar proteins; cd18641"
                     /db_xref="CDD:350843"
     Site            order(592..595,610,612..615,619,621..624,626..628,
                     631..632)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:350843"
     Site            order(592,612,615,619)
                     /site_type="other"
                     /note="putative methylated histone tail binding site
                     [chemical binding]"
                     /db_xref="CDD:350843"
     Site            order(609,611..616,618..622)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:350843"
     Site            order(609,612,616,618,622)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:350843"
     CDS             1..1277
                     /gene="ARID4A"
                     /gene_synonym="RBBP-1; RBBP1; RBP-1; RBP1"
                     /coded_by="XM_005267964.3:204..4037"
                     /db_xref="GeneID:5926"
                     /db_xref="HGNC:HGNC:9885"
                     /db_xref="MIM:180201"
ORIGIN      
        1 mkaadepayl tvgtdvsaky rgafceakik tvkrlvkvkv llkqdnttql vqddqvkgpl
       61 rvgaivetrt sdgsfqeaii skltdaswyt vvfddgdert lrrtslclkg erhfaesetl
      121 dqlpltnpeh fgtpviakkt nrgrrsslpv tedekeeess eeededkrrl ndellgkvvs
      181 vvsatertew ypalvispsc ndditvkkdq clvrsfidsk fysiarkdik evdilnlpes
      241 elstkpglqk asiflktrvv pdnwkmdise ilessssdde dgpaeendee kekeakktee
      301 evpeeeldpe erdnflqqly kfmedrgtpi nkppvlgykd lnlfklfrlv yhqggcdnid
      361 sgavwkqiym dlgipilnsa asynvktayr kylygfeeyc rsaniqfrtv hhhepkvkee
      421 kkdleesmee alkldqempl tevksepeen idsnsesere eielksprgr rriardvnsi
      481 kkeieeekte dklkdndten kdvdddyeta ekkenelllg rkntpkqkek kikkqedsdk
      541 dsdeeeeksq ereeteskcd segeedeedm epcltgtkvk vkygrgktqk iyeasikste
      601 iddgevlylv hyygwnvryd ewvkadriiw pldkggpkkk qkkkaknked sekdekrdee
      661 rqkskrgrpp lkstlssnmp yglsktanse gksgtrsars nipdssplsn gmedscssds
      721 etedaleknl ineelslkde leknenlndd kldeenpkis ahilkendrt qmqpletlkl
      781 evgeneqivq ifgnkmekte evkkeaeksp kgkgrrsktk dlsleiikis sfgqneagse
      841 phieahslel ssldnknfss atedeidqcv kekklkrkil gqsspekkir iengmemtnt
      901 vsqertsdci gsegmknlnf eqhfereneg mpsliaesnq ciqqltserf dspaeetvni
      961 plkededamp ligpetlvch evdlddldek dktsiedvav essesnslvs ippalppvvq
     1021 hnfsvasplt lsqdesrsvk sesditievd siaeesqegl ceresangfe tnvasgtcsi
     1081 ivqeresrek gqkrpsdgns glmakkqkrt pkrtsaaakn ekngtgqssd sedlpvldns
     1141 skctpvkhln vskpqklars parisphikd gekdkhrekh pnssprtykw sfqlneldnm
     1201 nsterisflq eklqeirkyy mslksevati drrrkrlkkk drevshagas mssassdtgm
     1261 spssssppqn vlavecr
//
LOCUS       XP_047287608            1277 aa            linear   PRI 05-AUG-2025
DEFINITION  AT-rich interactive domain-containing protein 4A isoform X1 [Homo
            sapiens].
ACCESSION   XP_047287608
VERSION     XP_047287608.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431652.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1277
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1277
                     /product="AT-rich interactive domain-containing protein 4A
                     isoform X1"
                     /calculated_mol_wt=144679
     Region          4..61
                     /region_name="Tudor_ARID4A_rpt1"
                     /note="first Tudor domain found in AT-rich interactive
                     domain-containing protein 4A (ARID4A) and similar
                     proteins; cd20459"
                     /db_xref="CDD:410530"
     Site            order(20,23,25,42,45,47)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410530"
     Region          62..114
                     /region_name="Tudor_ARID4_rpt2"
                     /note="second Tudor domain found in AT-rich interactive
                     domain-containing protein ARID4 family; cd20390"
                     /db_xref="CDD:410461"
     Site            order(70,74,76,93,95,97)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410461"
     Region          170..262
                     /region_name="RBB1NT"
                     /note="RBB1NT (NUC162) domain; pfam08169"
                     /db_xref="CDD:462390"
     Region          311..397
                     /region_name="ARID_ARID4A"
                     /note="ARID/BRIGHT DNA binding domain of AT-rich
                     interactive domain-containing protein 4A (ARID4A) and
                     similar proteins; cd16882"
                     /db_xref="CDD:350646"
     Site            order(332..338,363,365..366,369,380,382..384,386)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:350646"
     Region          577..635
                     /region_name="CBD_RBP1_like"
                     /note="chromo barrel domain of retinoblastoma binding
                     protein 1, and similar proteins; cd18641"
                     /db_xref="CDD:350843"
     Site            order(592..595,610,612..615,619,621..624,626..628,
                     631..632)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:350843"
     Site            order(592,612,615,619)
                     /site_type="other"
                     /note="putative methylated histone tail binding site
                     [chemical binding]"
                     /db_xref="CDD:350843"
     Site            order(609,611..616,618..622)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:350843"
     Site            order(609,612,616,618,622)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:350843"
     CDS             1..1277
                     /gene="ARID4A"
                     /gene_synonym="RBBP-1; RBBP1; RBP-1; RBP1"
                     /coded_by="XM_047431652.1:559..4392"
                     /db_xref="GeneID:5926"
                     /db_xref="HGNC:HGNC:9885"
                     /db_xref="MIM:180201"
ORIGIN      
        1 mkaadepayl tvgtdvsaky rgafceakik tvkrlvkvkv llkqdnttql vqddqvkgpl
       61 rvgaivetrt sdgsfqeaii skltdaswyt vvfddgdert lrrtslclkg erhfaesetl
      121 dqlpltnpeh fgtpviakkt nrgrrsslpv tedekeeess eeededkrrl ndellgkvvs
      181 vvsatertew ypalvispsc ndditvkkdq clvrsfidsk fysiarkdik evdilnlpes
      241 elstkpglqk asiflktrvv pdnwkmdise ilessssdde dgpaeendee kekeakktee
      301 evpeeeldpe erdnflqqly kfmedrgtpi nkppvlgykd lnlfklfrlv yhqggcdnid
      361 sgavwkqiym dlgipilnsa asynvktayr kylygfeeyc rsaniqfrtv hhhepkvkee
      421 kkdleesmee alkldqempl tevksepeen idsnsesere eielksprgr rriardvnsi
      481 kkeieeekte dklkdndten kdvdddyeta ekkenelllg rkntpkqkek kikkqedsdk
      541 dsdeeeeksq ereeteskcd segeedeedm epcltgtkvk vkygrgktqk iyeasikste
      601 iddgevlylv hyygwnvryd ewvkadriiw pldkggpkkk qkkkaknked sekdekrdee
      661 rqkskrgrpp lkstlssnmp yglsktanse gksgtrsars nipdssplsn gmedscssds
      721 etedaleknl ineelslkde leknenlndd kldeenpkis ahilkendrt qmqpletlkl
      781 evgeneqivq ifgnkmekte evkkeaeksp kgkgrrsktk dlsleiikis sfgqneagse
      841 phieahslel ssldnknfss atedeidqcv kekklkrkil gqsspekkir iengmemtnt
      901 vsqertsdci gsegmknlnf eqhfereneg mpsliaesnq ciqqltserf dspaeetvni
      961 plkededamp ligpetlvch evdlddldek dktsiedvav essesnslvs ippalppvvq
     1021 hnfsvasplt lsqdesrsvk sesditievd siaeesqegl ceresangfe tnvasgtcsi
     1081 ivqeresrek gqkrpsdgns glmakkqkrt pkrtsaaakn ekngtgqssd sedlpvldns
     1141 skctpvkhln vskpqklars parisphikd gekdkhrekh pnssprtykw sfqlneldnm
     1201 nsterisflq eklqeirkyy mslksevati drrrkrlkkk drevshagas mssassdtgm
     1261 spssssppqn vlavecr
//
LOCUS       XP_005268022            1208 aa            linear   PRI 05-AUG-2025
DEFINITION  AT-rich interactive domain-containing protein 4A isoform X2 [Homo
            sapiens].
ACCESSION   XP_005268022
VERSION     XP_005268022.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267965.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1208
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1208
                     /product="AT-rich interactive domain-containing protein 4A
                     isoform X2"
                     /calculated_mol_wt=136879
     Region          4..61
                     /region_name="Tudor_ARID4A_rpt1"
                     /note="first Tudor domain found in AT-rich interactive
                     domain-containing protein 4A (ARID4A) and similar
                     proteins; cd20459"
                     /db_xref="CDD:410530"
     Site            order(20,23,25,42,45,47)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410530"
     Region          62..114
                     /region_name="Tudor_ARID4_rpt2"
                     /note="second Tudor domain found in AT-rich interactive
                     domain-containing protein ARID4 family; cd20390"
                     /db_xref="CDD:410461"
     Site            order(70,74,76,93,95,97)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410461"
     Region          170..262
                     /region_name="RBB1NT"
                     /note="RBB1NT (NUC162) domain; pfam08169"
                     /db_xref="CDD:462390"
     Region          311..397
                     /region_name="ARID_ARID4A"
                     /note="ARID/BRIGHT DNA binding domain of AT-rich
                     interactive domain-containing protein 4A (ARID4A) and
                     similar proteins; cd16882"
                     /db_xref="CDD:350646"
     Site            order(332..338,363,365..366,369,380,382..384,386)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:350646"
     Region          577..635
                     /region_name="CBD_RBP1_like"
                     /note="chromo barrel domain of retinoblastoma binding
                     protein 1, and similar proteins; cd18641"
                     /db_xref="CDD:350843"
     Site            order(592..595,610,612..615,619,621..624,626..628,
                     631..632)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:350843"
     Site            order(592,612,615,619)
                     /site_type="other"
                     /note="putative methylated histone tail binding site
                     [chemical binding]"
                     /db_xref="CDD:350843"
     Site            order(609,611..616,618..622)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:350843"
     Site            order(609,612,616,618,622)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:350843"
     CDS             1..1208
                     /gene="ARID4A"
                     /gene_synonym="RBBP-1; RBBP1; RBP-1; RBP1"
                     /coded_by="XM_005267965.3:204..3830"
                     /db_xref="GeneID:5926"
                     /db_xref="HGNC:HGNC:9885"
                     /db_xref="MIM:180201"
ORIGIN      
        1 mkaadepayl tvgtdvsaky rgafceakik tvkrlvkvkv llkqdnttql vqddqvkgpl
       61 rvgaivetrt sdgsfqeaii skltdaswyt vvfddgdert lrrtslclkg erhfaesetl
      121 dqlpltnpeh fgtpviakkt nrgrrsslpv tedekeeess eeededkrrl ndellgkvvs
      181 vvsatertew ypalvispsc ndditvkkdq clvrsfidsk fysiarkdik evdilnlpes
      241 elstkpglqk asiflktrvv pdnwkmdise ilessssdde dgpaeendee kekeakktee
      301 evpeeeldpe erdnflqqly kfmedrgtpi nkppvlgykd lnlfklfrlv yhqggcdnid
      361 sgavwkqiym dlgipilnsa asynvktayr kylygfeeyc rsaniqfrtv hhhepkvkee
      421 kkdleesmee alkldqempl tevksepeen idsnsesere eielksprgr rriardvnsi
      481 kkeieeekte dklkdndten kdvdddyeta ekkenelllg rkntpkqkek kikkqedsdk
      541 dsdeeeeksq ereeteskcd segeedeedm epcltgtkvk vkygrgktqk iyeasikste
      601 iddgevlylv hyygwnvryd ewvkadriiw pldkggpkkk qkkkaknked sekdekrdee
      661 rqkskrgrpp lkstlssnmp yglsktanse gksgtrsars nipdssplsn gmedscssds
      721 etedaleknl ineelslkde leknenlndd kldeenpkis ahilkendrt qmqpletlkl
      781 evgeneqivq ifgnkmekte evkkeaeksp kgkgrrsktk dlsleiikis sfgqneagse
      841 phieahslel ssldnknfss atedeidqcv kekklkrkil gqsspekkir iengmemtnt
      901 vsqertsdci gsegmknlnf eqhfereneg mpsliaesnq ciqqltserf dspaeetvni
      961 plkededamp ligpetlvch evdlddldek dktsiedvav essesnslvs ippalppvvq
     1021 hnfsvasplt lsqdesrsvk sesditievd siaeesqegl ceresangfe tnvasgtcsi
     1081 ivqeresrek gqkrpsdgns glmakkqkrt pkrtsaaakn ekngtdeldn mnsterisfl
     1141 qeklqeirky ymslksevat idrrrkrlkk kdrevshaga smssassdtg mspssssppq
     1201 nvlavecr
//
LOCUS       XP_047287609            1130 aa            linear   PRI 05-AUG-2025
DEFINITION  AT-rich interactive domain-containing protein 4A isoform X3 [Homo
            sapiens].
ACCESSION   XP_047287609
VERSION     XP_047287609.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431653.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1130
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1130
                     /product="AT-rich interactive domain-containing protein 4A
                     isoform X3"
                     /calculated_mol_wt=128336
     Region          23..115
                     /region_name="RBB1NT"
                     /note="RBB1NT (NUC162) domain; pfam08169"
                     /db_xref="CDD:462390"
     Region          164..250
                     /region_name="ARID_ARID4A"
                     /note="ARID/BRIGHT DNA binding domain of AT-rich
                     interactive domain-containing protein 4A (ARID4A) and
                     similar proteins; cd16882"
                     /db_xref="CDD:350646"
     Site            order(185..191,216,218..219,222,233,235..237,239)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:350646"
     Region          430..488
                     /region_name="CBD_RBP1_like"
                     /note="chromo barrel domain of retinoblastoma binding
                     protein 1, and similar proteins; cd18641"
                     /db_xref="CDD:350843"
     Site            order(445..448,463,465..468,472,474..477,479..481,
                     484..485)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:350843"
     Site            order(445,465,468,472)
                     /site_type="other"
                     /note="putative methylated histone tail binding site
                     [chemical binding]"
                     /db_xref="CDD:350843"
     Site            order(462,464..469,471..475)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:350843"
     Site            order(462,465,469,471,475)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:350843"
     CDS             1..1130
                     /gene="ARID4A"
                     /gene_synonym="RBBP-1; RBBP1; RBP-1; RBP1"
                     /coded_by="XM_047431653.1:631..4023"
                     /db_xref="GeneID:5926"
                     /db_xref="HGNC:HGNC:9885"
                     /db_xref="MIM:180201"
ORIGIN      
        1 mtstedekee esseeededk rrlndellgk vvsvvsater tewypalvis pscndditvk
       61 kdqclvrsfi dskfysiark dikevdilnl peselstkpg lqkasiflkt rvvpdnwkmd
      121 iseilessss ddedgpaeen deekekeakk teeevpeeel dpeerdnflq qlykfmedrg
      181 tpinkppvlg ykdlnlfklf rlvyhqggcd nidsgavwkq iymdlgipil nsaasynvkt
      241 ayrkylygfe eycrsaniqf rtvhhhepkv keekkdlees meealkldqe mpltevksep
      301 eenidsnses ereeielksp rgrrriardv nsikkeieee ktedklkdnd tenkdvdddy
      361 etaekkenel llgrkntpkq kekkikkqed sdkdsdeeee ksqereetes kcdsegeede
      421 edmepcltgt kvkvkygrgk tqkiyeasik steiddgevl ylvhyygwnv rydewvkadr
      481 iiwpldkggp kkkqkkkakn kedsekdekr deerqkskrg rpplkstlss nmpyglskta
      541 nsegksgtrs arsnipdssp lsngmedscs sdsetedale knlineelsl kdeleknenl
      601 nddkldeenp kisahilken drtqmqplet lklevgeneq ivqifgnkme kteevkkeae
      661 kspkgkgrrs ktkdlsleii kissfgqnea gsephieahs lelssldnkn fssatedeid
      721 qcvkekklkr kilgqsspek kiriengmem tntvsqerts dcigsegmkn lnfeqhfere
      781 negmpsliae snqciqqlts erfdspaeet vniplkeded ampligpetl vchevdlddl
      841 dekdktsied vavessesns lvsippalpp vvqhnfsvas pltlsqdesr svksesditi
      901 evdsiaeesq eglceresan gfetnvasgt csiivqeres rekgqkrpsd gnsglmakkq
      961 krtpkrtsaa aknekngtgq ssdsedlpvl dnsskctpvk hlnvskpqkl arsparisph
     1021 ikdgekdkhr ekhpnssprt ykwsfqlnel dnmnsteris flqeklqeir kyymslksev
     1081 atidrrrkrl kkkdrevsha gasmssassd tgmspssssp pqnvlavecr
//
LOCUS       XP_047287610             955 aa            linear   PRI 05-AUG-2025
DEFINITION  AT-rich interactive domain-containing protein 4A isoform X4 [Homo
            sapiens].
ACCESSION   XP_047287610
VERSION     XP_047287610.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431654.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..955
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..955
                     /product="AT-rich interactive domain-containing protein 4A
                     isoform X4"
                     /calculated_mol_wt=108152
     Region          1..75
                     /region_name="ARID"
                     /note="ARID/BRIGHT DNA binding domain family; cl28902"
                     /db_xref="CDD:355778"
     Site            order(10..16,41,43..44,47,58,60..62,64)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:350646"
     Region          255..313
                     /region_name="CBD_RBP1_like"
                     /note="chromo barrel domain of retinoblastoma binding
                     protein 1, and similar proteins; cd18641"
                     /db_xref="CDD:350843"
     Site            order(270..273,288,290..293,297,299..302,304..306,
                     309..310)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:350843"
     Site            order(270,290,293,297)
                     /site_type="other"
                     /note="putative methylated histone tail binding site
                     [chemical binding]"
                     /db_xref="CDD:350843"
     Site            order(287,289..294,296..300)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:350843"
     Site            order(287,290,294,296,300)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:350843"
     CDS             1..955
                     /gene="ARID4A"
                     /gene_synonym="RBBP-1; RBBP1; RBP-1; RBP1"
                     /coded_by="XM_047431654.1:296..3163"
                     /db_xref="GeneID:5926"
                     /db_xref="HGNC:HGNC:9885"
                     /db_xref="MIM:180201"
ORIGIN      
        1 medrgtpink ppvlgykdln lfklfrlvyh qggcdnidsg avwkqiymdl gipilnsaas
       61 ynvktayrky lygfeeycrs aniqfrtvhh hepkvkeekk dleesmeeal kldqemplte
      121 vksepeenid snsesereei elksprgrrr iardvnsikk eieeektedk lkdndtenkd
      181 vdddyetaek kenelllgrk ntpkqkekki kkqedsdkds deeeeksqer eeteskcdse
      241 geedeedmep cltgtkvkvk ygrgktqkiy easiksteid dgevlylvhy ygwnvrydew
      301 vkadriiwpl dkggpkkkqk kkaknkedse kdekrdeerq kskrgrpplk stlssnmpyg
      361 lsktansegk sgtrsarsni pdssplsngm edscssdset edaleknlin eelslkdele
      421 knenlnddkl deenpkisah ilkendrtqm qpletlklev geneqivqif gnkmekteev
      481 kkeaekspkg kgrrsktkdl sleiikissf gqneagseph ieahslelss ldnknfssat
      541 edeidqcvke kklkrkilgq sspekkirie ngmemtntvs qertsdcigs egmknlnfeq
      601 hferenegmp sliaesnqci qqltserfds paeetvnipl kededampli gpetlvchev
      661 dlddldekdk tsiedvaves sesnslvsip palppvvqhn fsvaspltls qdesrsvkse
      721 sditievdsi aeesqeglce resangfetn vasgtcsiiv qeresrekgq krpsdgnsgl
      781 makkqkrtpk rtsaaaknek ngtgqssdse dlpvldnssk ctpvkhlnvs kpqklarspa
      841 risphikdge kdkhrekhpn ssprtykwsf qlneldnmns terisflqek lqeirkyyms
      901 lksevatidr rrkrlkkkdr evshagasms sassdtgmsp ssssppqnvl avecr
//
LOCUS       XP_047287611             708 aa            linear   PRI 05-AUG-2025
DEFINITION  AT-rich interactive domain-containing protein 4A isoform X5 [Homo
            sapiens].
ACCESSION   XP_047287611
VERSION     XP_047287611.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431655.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..708
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..708
                     /product="AT-rich interactive domain-containing protein 4A
                     isoform X5"
                     /calculated_mol_wt=79195
     Region          8..66
                     /region_name="CBD_RBP1_like"
                     /note="chromo barrel domain of retinoblastoma binding
                     protein 1, and similar proteins; cd18641"
                     /db_xref="CDD:350843"
     Site            order(23..26,41,43..46,50,52..55,57..59,62..63)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:350843"
     Site            order(23,43,46,50)
                     /site_type="other"
                     /note="putative methylated histone tail binding site
                     [chemical binding]"
                     /db_xref="CDD:350843"
     Site            order(40,42..47,49..53)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:350843"
     Site            order(40,43,47,49,53)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:350843"
     CDS             1..708
                     /gene="ARID4A"
                     /gene_synonym="RBBP-1; RBBP1; RBP-1; RBP1"
                     /coded_by="XM_047431655.1:152..2278"
                     /db_xref="GeneID:5926"
                     /db_xref="HGNC:HGNC:9885"
                     /db_xref="MIM:180201"
ORIGIN      
        1 mepcltgtkv kvkygrgktq kiyeasikst eiddgevlyl vhyygwnvry dewvkadrii
       61 wpldkggpkk kqkkkaknke dsekdekrde erqkskrgrp plkstlssnm pyglsktans
      121 egksgtrsar snipdsspls ngmedscssd setedalekn lineelslkd eleknenlnd
      181 dkldeenpki sahilkendr tqmqpletlk levgeneqiv qifgnkmekt eevkkeaeks
      241 pkgkgrrskt kdlsleiiki ssfgqneags ephieahsle lssldnknfs satedeidqc
      301 vkekklkrki lgqsspekki riengmemtn tvsqertsdc igsegmknln feqhferene
      361 gmpsliaesn qciqqltser fdspaeetvn iplkededam pligpetlvc hevdlddlde
      421 kdktsiedva vessesnslv sippalppvv qhnfsvaspl tlsqdesrsv ksesditiev
      481 dsiaeesqeg lceresangf etnvasgtcs iivqeresre kgqkrpsdgn sglmakkqkr
      541 tpkrtsaaak nekngtgqss dsedlpvldn sskctpvkhl nvskpqklar sparisphik
      601 dgekdkhrek hpnssprtyk wsfqlneldn mnsterisfl qeklqeirky ymslksevat
      661 idrrrkrlkk kdrevshaga smssassdtg mspssssppq nvlavecr
//
LOCUS       XP_047287612             552 aa            linear   PRI 05-AUG-2025
DEFINITION  AT-rich interactive domain-containing protein 4A isoform X6 [Homo
            sapiens].
ACCESSION   XP_047287612
VERSION     XP_047287612.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431656.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..552
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..552
                     /product="AT-rich interactive domain-containing protein 4A
                     isoform X6"
                     /calculated_mol_wt=63430
     Region          4..61
                     /region_name="Tudor_ARID4A_rpt1"
                     /note="first Tudor domain found in AT-rich interactive
                     domain-containing protein 4A (ARID4A) and similar
                     proteins; cd20459"
                     /db_xref="CDD:410530"
     Site            order(20,23,25,42,45,47)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410530"
     Region          62..118
                     /region_name="Tudor_SF"
                     /note="Tudor domain superfamily; cl02573"
                     /db_xref="CDD:470623"
     Site            order(70,74,76,93,95,97)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410449"
     Region          170..262
                     /region_name="RBB1NT"
                     /note="RBB1NT (NUC162) domain; pfam08169"
                     /db_xref="CDD:462390"
     Region          311..397
                     /region_name="ARID_ARID4A"
                     /note="ARID/BRIGHT DNA binding domain of AT-rich
                     interactive domain-containing protein 4A (ARID4A) and
                     similar proteins; cd16882"
                     /db_xref="CDD:350646"
     Site            order(332..338,363,365..366,369,380,382..384,386)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:350646"
     CDS             1..552
                     /gene="ARID4A"
                     /gene_synonym="RBBP-1; RBBP1; RBP-1; RBP1"
                     /coded_by="XM_047431656.1:204..1862"
                     /db_xref="GeneID:5926"
                     /db_xref="HGNC:HGNC:9885"
                     /db_xref="MIM:180201"
ORIGIN      
        1 mkaadepayl tvgtdvsaky rgafceakik tvkrlvkvkv llkqdnttql vqddqvkgpl
       61 rvgaivetrt sdgsfqeaii skltdaswyt vvfddgdert lrrtslclkg erhfaesetl
      121 dqlpltnpeh fgtpviakkt nrgrrsslpv tedekeeess eeededkrrl ndellgkvvs
      181 vvsatertew ypalvispsc ndditvkkdq clvrsfidsk fysiarkdik evdilnlpes
      241 elstkpglqk asiflktrvv pdnwkmdise ilessssdde dgpaeendee kekeakktee
      301 evpeeeldpe erdnflqqly kfmedrgtpi nkppvlgykd lnlfklfrlv yhqggcdnid
      361 sgavwkqiym dlgipilnsa asynvktayr kylygfeeyc rsaniqfrtv hhhepkvkee
      421 kkdleesmee alkldqempl tevksepeen idsnsesere eielksprgr rriardvnsi
      481 kkeieeekte dklkdndten kdvdddyeta ekkenelllg rkntpkqkek kikkqedsdk
      541 dsdeeeeksq er
//
LOCUS       XP_016877055             150 aa            linear   PRI 05-AUG-2025
DEFINITION  ribonuclease K6 isoform X1 [Homo sapiens].
ACCESSION   XP_016877055
VERSION     XP_016877055.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021566.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..150
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..150
                     /product="ribonuclease K6 isoform X1"
                     /calculated_mol_wt=17065
     Region          29..147
                     /region_name="RnaseA"
                     /note="Pancreatic ribonuclease; pfam00074"
                     /db_xref="CDD:459661"
     Site            order(34..43,45,49,51..53,61,64..69,102,120,143)
                     /site_type="active"
                     /note="dimerization with domain swap [active]"
                     /db_xref="CDD:119387"
     Site            order(38,61,65,91,103,145..146)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:119387"
     Site            order(62,94,105,119,121,123..124,126)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:119387"
     CDS             1..150
                     /gene="RNASE6"
                     /gene_synonym="RAD1; RNasek6; RNS6"
                     /coded_by="XM_017021566.2:162..614"
                     /db_xref="GeneID:6039"
                     /db_xref="HGNC:HGNC:10048"
                     /db_xref="MIM:601981"
ORIGIN      
        1 mvlcfpllll llvlwgpvcp lhawpkrltk ahwfeiqhiq psplqcnram sginnytqhc
       61 khqntflhds fqnvaavcdl lsivcknrrh nchqsskpvn mtdcrltsgk ypqcrysaaa
      121 qykffivacd ppqksdppyk lvpvhldsil
//
LOCUS       XP_011535359             350 aa            linear   PRI 05-AUG-2025
DEFINITION  protein salvador homolog 1 isoform X1 [Homo sapiens].
ACCESSION   XP_011535359
VERSION     XP_011535359.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537057.4
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 32% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..350
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..350
                     /product="protein salvador homolog 1 isoform X1"
                     /calculated_mol_wt=40719
     Region          169..199
                     /region_name="WW"
                     /note="Two conserved tryptophans domain; also known as the
                     WWP or rsp5 domain; around 40 amino acids; functions as an
                     interaction module in a diverse set of signalling
                     proteins; binds specific proline-rich sequences but at low
                     affinities compared to other...; cd00201"
                     /db_xref="CDD:238122"
     Site            order(183,194)
                     /site_type="active"
                     /note="binding pocket [active]"
                     /db_xref="CDD:238122"
     Region          204..233
                     /region_name="WW"
                     /note="Two conserved tryptophans domain; also known as the
                     WWP or rsp5 domain; around 40 amino acids; functions as an
                     interaction module in a diverse set of signalling
                     proteins; binds specific proline-rich sequences but at low
                     affinities compared to other...; cd00201"
                     /db_xref="CDD:238122"
     Site            order(218,229)
                     /site_type="active"
                     /note="binding pocket [active]"
                     /db_xref="CDD:238122"
     Region          269..335
                     /region_name="SARAH_Sav"
                     /note="C-terminal SARAH domain of Drosophila melanogaster
                     scaffold protein salvador (Sav) and similar proteins;
                     cd21433"
                     /db_xref="CDD:439176"
     Site            order(275,278..287,291..292,294..296,299..300,302..303,
                     306..307,309..310,313..314,317..318,320..321,323..325,
                     327..329,331..332,335)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:439176"
     CDS             1..350
                     /gene="SAV1"
                     /gene_synonym="SAV; WW45; WWP4"
                     /coded_by="XM_011537057.4:558..1610"
                     /db_xref="GeneID:60485"
                     /db_xref="HGNC:HGNC:17795"
                     /db_xref="MIM:607203"
ORIGIN      
        1 mpsfirhgpt iprrtdiclp dsspnafsts gdvvsrnqsf lrtpiqrtph eimrresnrl
       61 sapsylarsl advpreygss qsfvtevsfa vengdsgsry yysdnffdgq rkrplgdrah
      121 edyryyeynh dlfqrmpqnq grhasgigrv aatslgnltn hgsedlplpp gwsvdwtmrg
      181 rkyyidhntn tthwshpler eglppgwerv essefgtyyv dhtnkkaqyr hpcapsvpry
      241 dqpppvtyqp qqternqsll vpanpyhtae ipdwlqvyar apvkydhilk welfqladld
      301 tyqgmlkllf mkeleqivkm yeayrqallt elenrkqrqq wyaqqhgknf
//
LOCUS       XP_047287615             205 aa            linear   PRI 05-AUG-2025
DEFINITION  protein salvador homolog 1 isoform X2 [Homo sapiens].
ACCESSION   XP_047287615
VERSION     XP_047287615.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431659.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..205
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..205
                     /product="protein salvador homolog 1 isoform X2"
                     /calculated_mol_wt=23415
     CDS             1..205
                     /gene="SAV1"
                     /gene_synonym="SAV; WW45; WWP4"
                     /coded_by="XM_047431659.1:340..957"
                     /db_xref="GeneID:60485"
                     /db_xref="HGNC:HGNC:17795"
                     /db_xref="MIM:607203"
ORIGIN      
        1 mlsrkktkne vskpaevqgk yvkketspll rnlmpsfirh gptiprrtdi clpdsspnaf
       61 stsgdvvsrn qsflrtpiqr tpheimrres nrlsapsyla rsladvprey gssqsfvtev
      121 sfavengdsg sryyysdnff dgqrkrplgd rahedyryye ynhdlfqrmp qnqgrhasdt
      181 vletgdvsvn ktkipvlrif fvgfl
//
LOCUS       XP_047287616             538 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein C14orf93 isoform X1 [Homo sapiens].
ACCESSION   XP_047287616
VERSION     XP_047287616.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431660.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..538
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..538
                     /product="uncharacterized protein C14orf93 isoform X1"
                     /calculated_mol_wt=58566
     Region          2..538
                     /region_name="DUF4616"
                     /note="Domain of unknown function (DUF4616); pfam15394"
                     /db_xref="CDD:464701"
     CDS             1..538
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
                     /coded_by="XM_047431660.1:586..2202"
                     /db_xref="GeneID:60686"
                     /db_xref="HGNC:HGNC:20162"
ORIGIN      
        1 msfsatilfs ppsgsearcc ccacksetng gntgsqggnp ppstpitvtg hglavqsseq
       61 llhviyqrvd kavglaeaal glarannell krlqeevgdl rqgkvsipde dgesrahssp
      121 peepgplkes pgeafkalsa veeecdsvgs gvqvvieelr qlgaasvgpg plgfpatqrd
      181 mrlpgctlaa seaapllnpl vddyvasega vqrvlvpaya kqlspatqla iqratpetgp
      241 engtklpppr pedmlnaaaa ldsaleesgp gstgelrhsl gltvspcrtr gsgqknsrrk
      301 rdlvlsklvh nvhnhitndk rfngsesiks swnisvvkfl leklkqelvt sphnytdkel
      361 kgacvayflt krreyrnsln pfkglkekee kklrsrryrl fanrssimrh fgpedqrlwn
      421 dvteelmsde edslnepgvw varpprfraq rltelcyhld anskhgtkan rvygppsdrl
      481 psaeaqllpp elynpnfqee edeggdenap gspsfdqphk tccpdlnsfi eikvekde
//
LOCUS       XP_016877061             538 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein C14orf93 isoform X1 [Homo sapiens].
ACCESSION   XP_016877061
VERSION     XP_016877061.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021572.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..538
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..538
                     /product="uncharacterized protein C14orf93 isoform X1"
                     /calculated_mol_wt=58566
     Region          2..538
                     /region_name="DUF4616"
                     /note="Domain of unknown function (DUF4616); pfam15394"
                     /db_xref="CDD:464701"
     CDS             1..538
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
                     /coded_by="XM_017021572.3:5498..7114"
                     /db_xref="GeneID:60686"
                     /db_xref="HGNC:HGNC:20162"
ORIGIN      
        1 msfsatilfs ppsgsearcc ccacksetng gntgsqggnp ppstpitvtg hglavqsseq
       61 llhviyqrvd kavglaeaal glarannell krlqeevgdl rqgkvsipde dgesrahssp
      121 peepgplkes pgeafkalsa veeecdsvgs gvqvvieelr qlgaasvgpg plgfpatqrd
      181 mrlpgctlaa seaapllnpl vddyvasega vqrvlvpaya kqlspatqla iqratpetgp
      241 engtklpppr pedmlnaaaa ldsaleesgp gstgelrhsl gltvspcrtr gsgqknsrrk
      301 rdlvlsklvh nvhnhitndk rfngsesiks swnisvvkfl leklkqelvt sphnytdkel
      361 kgacvayflt krreyrnsln pfkglkekee kklrsrryrl fanrssimrh fgpedqrlwn
      421 dvteelmsde edslnepgvw varpprfraq rltelcyhld anskhgtkan rvygppsdrl
      481 psaeaqllpp elynpnfqee edeggdenap gspsfdqphk tccpdlnsfi eikvekde
//
LOCUS       XP_016877062             538 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein C14orf93 isoform X1 [Homo sapiens].
ACCESSION   XP_016877062
VERSION     XP_016877062.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021573.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..538
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..538
                     /product="uncharacterized protein C14orf93 isoform X1"
                     /calculated_mol_wt=58566
     Region          2..538
                     /region_name="DUF4616"
                     /note="Domain of unknown function (DUF4616); pfam15394"
                     /db_xref="CDD:464701"
     CDS             1..538
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
                     /coded_by="XM_017021573.2:502..2118"
                     /db_xref="GeneID:60686"
                     /db_xref="HGNC:HGNC:20162"
ORIGIN      
        1 msfsatilfs ppsgsearcc ccacksetng gntgsqggnp ppstpitvtg hglavqsseq
       61 llhviyqrvd kavglaeaal glarannell krlqeevgdl rqgkvsipde dgesrahssp
      121 peepgplkes pgeafkalsa veeecdsvgs gvqvvieelr qlgaasvgpg plgfpatqrd
      181 mrlpgctlaa seaapllnpl vddyvasega vqrvlvpaya kqlspatqla iqratpetgp
      241 engtklpppr pedmlnaaaa ldsaleesgp gstgelrhsl gltvspcrtr gsgqknsrrk
      301 rdlvlsklvh nvhnhitndk rfngsesiks swnisvvkfl leklkqelvt sphnytdkel
      361 kgacvayflt krreyrnsln pfkglkekee kklrsrryrl fanrssimrh fgpedqrlwn
      421 dvteelmsde edslnepgvw varpprfraq rltelcyhld anskhgtkan rvygppsdrl
      481 psaeaqllpp elynpnfqee edeggdenap gspsfdqphk tccpdlnsfi eikvekde
//
LOCUS       XP_047287617             538 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein C14orf93 isoform X1 [Homo sapiens].
ACCESSION   XP_047287617
VERSION     XP_047287617.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431661.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..538
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..538
                     /product="uncharacterized protein C14orf93 isoform X1"
                     /calculated_mol_wt=58566
     Region          2..538
                     /region_name="DUF4616"
                     /note="Domain of unknown function (DUF4616); pfam15394"
                     /db_xref="CDD:464701"
     CDS             1..538
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
                     /coded_by="XM_047431661.1:5659..7275"
                     /db_xref="GeneID:60686"
                     /db_xref="HGNC:HGNC:20162"
ORIGIN      
        1 msfsatilfs ppsgsearcc ccacksetng gntgsqggnp ppstpitvtg hglavqsseq
       61 llhviyqrvd kavglaeaal glarannell krlqeevgdl rqgkvsipde dgesrahssp
      121 peepgplkes pgeafkalsa veeecdsvgs gvqvvieelr qlgaasvgpg plgfpatqrd
      181 mrlpgctlaa seaapllnpl vddyvasega vqrvlvpaya kqlspatqla iqratpetgp
      241 engtklpppr pedmlnaaaa ldsaleesgp gstgelrhsl gltvspcrtr gsgqknsrrk
      301 rdlvlsklvh nvhnhitndk rfngsesiks swnisvvkfl leklkqelvt sphnytdkel
      361 kgacvayflt krreyrnsln pfkglkekee kklrsrryrl fanrssimrh fgpedqrlwn
      421 dvteelmsde edslnepgvw varpprfraq rltelcyhld anskhgtkan rvygppsdrl
      481 psaeaqllpp elynpnfqee edeggdenap gspsfdqphk tccpdlnsfi eikvekde
//
LOCUS       XP_047287618             538 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein C14orf93 isoform X1 [Homo sapiens].
ACCESSION   XP_047287618
VERSION     XP_047287618.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431662.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..538
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..538
                     /product="uncharacterized protein C14orf93 isoform X1"
                     /calculated_mol_wt=58566
     Region          2..538
                     /region_name="DUF4616"
                     /note="Domain of unknown function (DUF4616); pfam15394"
                     /db_xref="CDD:464701"
     CDS             1..538
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
                     /coded_by="XM_047431662.1:546..2162"
                     /db_xref="GeneID:60686"
                     /db_xref="HGNC:HGNC:20162"
ORIGIN      
        1 msfsatilfs ppsgsearcc ccacksetng gntgsqggnp ppstpitvtg hglavqsseq
       61 llhviyqrvd kavglaeaal glarannell krlqeevgdl rqgkvsipde dgesrahssp
      121 peepgplkes pgeafkalsa veeecdsvgs gvqvvieelr qlgaasvgpg plgfpatqrd
      181 mrlpgctlaa seaapllnpl vddyvasega vqrvlvpaya kqlspatqla iqratpetgp
      241 engtklpppr pedmlnaaaa ldsaleesgp gstgelrhsl gltvspcrtr gsgqknsrrk
      301 rdlvlsklvh nvhnhitndk rfngsesiks swnisvvkfl leklkqelvt sphnytdkel
      361 kgacvayflt krreyrnsln pfkglkekee kklrsrryrl fanrssimrh fgpedqrlwn
      421 dvteelmsde edslnepgvw varpprfraq rltelcyhld anskhgtkan rvygppsdrl
      481 psaeaqllpp elynpnfqee edeggdenap gspsfdqphk tccpdlnsfi eikvekde
//
LOCUS       XP_011535361             538 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein C14orf93 isoform X1 [Homo sapiens].
ACCESSION   XP_011535361
VERSION     XP_011535361.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537059.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..538
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..538
                     /product="uncharacterized protein C14orf93 isoform X1"
                     /calculated_mol_wt=58566
     Region          2..538
                     /region_name="DUF4616"
                     /note="Domain of unknown function (DUF4616); pfam15394"
                     /db_xref="CDD:464701"
     CDS             1..538
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
                     /coded_by="XM_011537059.2:467..2083"
                     /db_xref="GeneID:60686"
                     /db_xref="HGNC:HGNC:20162"
ORIGIN      
        1 msfsatilfs ppsgsearcc ccacksetng gntgsqggnp ppstpitvtg hglavqsseq
       61 llhviyqrvd kavglaeaal glarannell krlqeevgdl rqgkvsipde dgesrahssp
      121 peepgplkes pgeafkalsa veeecdsvgs gvqvvieelr qlgaasvgpg plgfpatqrd
      181 mrlpgctlaa seaapllnpl vddyvasega vqrvlvpaya kqlspatqla iqratpetgp
      241 engtklpppr pedmlnaaaa ldsaleesgp gstgelrhsl gltvspcrtr gsgqknsrrk
      301 rdlvlsklvh nvhnhitndk rfngsesiks swnisvvkfl leklkqelvt sphnytdkel
      361 kgacvayflt krreyrnsln pfkglkekee kklrsrryrl fanrssimrh fgpedqrlwn
      421 dvteelmsde edslnepgvw varpprfraq rltelcyhld anskhgtkan rvygppsdrl
      481 psaeaqllpp elynpnfqee edeggdenap gspsfdqphk tccpdlnsfi eikvekde
//
LOCUS       XP_047287619             538 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein C14orf93 isoform X1 [Homo sapiens].
ACCESSION   XP_047287619
VERSION     XP_047287619.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431663.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..538
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..538
                     /product="uncharacterized protein C14orf93 isoform X1"
                     /calculated_mol_wt=58566
     Region          2..538
                     /region_name="DUF4616"
                     /note="Domain of unknown function (DUF4616); pfam15394"
                     /db_xref="CDD:464701"
     CDS             1..538
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
                     /coded_by="XM_047431663.1:462..2078"
                     /db_xref="GeneID:60686"
                     /db_xref="HGNC:HGNC:20162"
ORIGIN      
        1 msfsatilfs ppsgsearcc ccacksetng gntgsqggnp ppstpitvtg hglavqsseq
       61 llhviyqrvd kavglaeaal glarannell krlqeevgdl rqgkvsipde dgesrahssp
      121 peepgplkes pgeafkalsa veeecdsvgs gvqvvieelr qlgaasvgpg plgfpatqrd
      181 mrlpgctlaa seaapllnpl vddyvasega vqrvlvpaya kqlspatqla iqratpetgp
      241 engtklpppr pedmlnaaaa ldsaleesgp gstgelrhsl gltvspcrtr gsgqknsrrk
      301 rdlvlsklvh nvhnhitndk rfngsesiks swnisvvkfl leklkqelvt sphnytdkel
      361 kgacvayflt krreyrnsln pfkglkekee kklrsrryrl fanrssimrh fgpedqrlwn
      421 dvteelmsde edslnepgvw varpprfraq rltelcyhld anskhgtkan rvygppsdrl
      481 psaeaqllpp elynpnfqee edeggdenap gspsfdqphk tccpdlnsfi eikvekde
//
LOCUS       XP_047287620             538 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein C14orf93 isoform X1 [Homo sapiens].
ACCESSION   XP_047287620
VERSION     XP_047287620.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431664.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..538
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..538
                     /product="uncharacterized protein C14orf93 isoform X1"
                     /calculated_mol_wt=58566
     Region          2..538
                     /region_name="DUF4616"
                     /note="Domain of unknown function (DUF4616); pfam15394"
                     /db_xref="CDD:464701"
     CDS             1..538
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
                     /coded_by="XM_047431664.1:707..2323"
                     /db_xref="GeneID:60686"
                     /db_xref="HGNC:HGNC:20162"
ORIGIN      
        1 msfsatilfs ppsgsearcc ccacksetng gntgsqggnp ppstpitvtg hglavqsseq
       61 llhviyqrvd kavglaeaal glarannell krlqeevgdl rqgkvsipde dgesrahssp
      121 peepgplkes pgeafkalsa veeecdsvgs gvqvvieelr qlgaasvgpg plgfpatqrd
      181 mrlpgctlaa seaapllnpl vddyvasega vqrvlvpaya kqlspatqla iqratpetgp
      241 engtklpppr pedmlnaaaa ldsaleesgp gstgelrhsl gltvspcrtr gsgqknsrrk
      301 rdlvlsklvh nvhnhitndk rfngsesiks swnisvvkfl leklkqelvt sphnytdkel
      361 kgacvayflt krreyrnsln pfkglkekee kklrsrryrl fanrssimrh fgpedqrlwn
      421 dvteelmsde edslnepgvw varpprfraq rltelcyhld anskhgtkan rvygppsdrl
      481 psaeaqllpp elynpnfqee edeggdenap gspsfdqphk tccpdlnsfi eikvekde
//
LOCUS       XP_005268028             538 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein C14orf93 isoform X1 [Homo sapiens].
ACCESSION   XP_005268028
VERSION     XP_005268028.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267971.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..538
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..538
                     /product="uncharacterized protein C14orf93 isoform X1"
                     /calculated_mol_wt=58566
     Region          2..538
                     /region_name="DUF4616"
                     /note="Domain of unknown function (DUF4616); pfam15394"
                     /db_xref="CDD:464701"
     CDS             1..538
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
                     /coded_by="XM_005267971.2:383..1999"
                     /db_xref="GeneID:60686"
                     /db_xref="HGNC:HGNC:20162"
ORIGIN      
        1 msfsatilfs ppsgsearcc ccacksetng gntgsqggnp ppstpitvtg hglavqsseq
       61 llhviyqrvd kavglaeaal glarannell krlqeevgdl rqgkvsipde dgesrahssp
      121 peepgplkes pgeafkalsa veeecdsvgs gvqvvieelr qlgaasvgpg plgfpatqrd
      181 mrlpgctlaa seaapllnpl vddyvasega vqrvlvpaya kqlspatqla iqratpetgp
      241 engtklpppr pedmlnaaaa ldsaleesgp gstgelrhsl gltvspcrtr gsgqknsrrk
      301 rdlvlsklvh nvhnhitndk rfngsesiks swnisvvkfl leklkqelvt sphnytdkel
      361 kgacvayflt krreyrnsln pfkglkekee kklrsrryrl fanrssimrh fgpedqrlwn
      421 dvteelmsde edslnepgvw varpprfraq rltelcyhld anskhgtkan rvygppsdrl
      481 psaeaqllpp elynpnfqee edeggdenap gspsfdqphk tccpdlnsfi eikvekde
//
LOCUS       XP_011535362             538 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein C14orf93 isoform X1 [Homo sapiens].
ACCESSION   XP_011535362
VERSION     XP_011535362.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537060.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..538
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..538
                     /product="uncharacterized protein C14orf93 isoform X1"
                     /calculated_mol_wt=58566
     Region          2..538
                     /region_name="DUF4616"
                     /note="Domain of unknown function (DUF4616); pfam15394"
                     /db_xref="CDD:464701"
     CDS             1..538
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
                     /coded_by="XM_011537060.4:5292..6908"
                     /db_xref="GeneID:60686"
                     /db_xref="HGNC:HGNC:20162"
ORIGIN      
        1 msfsatilfs ppsgsearcc ccacksetng gntgsqggnp ppstpitvtg hglavqsseq
       61 llhviyqrvd kavglaeaal glarannell krlqeevgdl rqgkvsipde dgesrahssp
      121 peepgplkes pgeafkalsa veeecdsvgs gvqvvieelr qlgaasvgpg plgfpatqrd
      181 mrlpgctlaa seaapllnpl vddyvasega vqrvlvpaya kqlspatqla iqratpetgp
      241 engtklpppr pedmlnaaaa ldsaleesgp gstgelrhsl gltvspcrtr gsgqknsrrk
      301 rdlvlsklvh nvhnhitndk rfngsesiks swnisvvkfl leklkqelvt sphnytdkel
      361 kgacvayflt krreyrnsln pfkglkekee kklrsrryrl fanrssimrh fgpedqrlwn
      421 dvteelmsde edslnepgvw varpprfraq rltelcyhld anskhgtkan rvygppsdrl
      481 psaeaqllpp elynpnfqee edeggdenap gspsfdqphk tccpdlnsfi eikvekde
//
LOCUS       XP_016877063             538 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein C14orf93 isoform X1 [Homo sapiens].
ACCESSION   XP_016877063
VERSION     XP_016877063.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021574.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..538
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..538
                     /product="uncharacterized protein C14orf93 isoform X1"
                     /calculated_mol_wt=58566
     Region          2..538
                     /region_name="DUF4616"
                     /note="Domain of unknown function (DUF4616); pfam15394"
                     /db_xref="CDD:464701"
     CDS             1..538
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
                     /coded_by="XM_017021574.3:5453..7069"
                     /db_xref="GeneID:60686"
                     /db_xref="HGNC:HGNC:20162"
ORIGIN      
        1 msfsatilfs ppsgsearcc ccacksetng gntgsqggnp ppstpitvtg hglavqsseq
       61 llhviyqrvd kavglaeaal glarannell krlqeevgdl rqgkvsipde dgesrahssp
      121 peepgplkes pgeafkalsa veeecdsvgs gvqvvieelr qlgaasvgpg plgfpatqrd
      181 mrlpgctlaa seaapllnpl vddyvasega vqrvlvpaya kqlspatqla iqratpetgp
      241 engtklpppr pedmlnaaaa ldsaleesgp gstgelrhsl gltvspcrtr gsgqknsrrk
      301 rdlvlsklvh nvhnhitndk rfngsesiks swnisvvkfl leklkqelvt sphnytdkel
      361 kgacvayflt krreyrnsln pfkglkekee kklrsrryrl fanrssimrh fgpedqrlwn
      421 dvteelmsde edslnepgvw varpprfraq rltelcyhld anskhgtkan rvygppsdrl
      481 psaeaqllpp elynpnfqee edeggdenap gspsfdqphk tccpdlnsfi eikvekde
//
LOCUS       XP_005268029             538 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein C14orf93 isoform X1 [Homo sapiens].
ACCESSION   XP_005268029
VERSION     XP_005268029.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267972.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..538
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..538
                     /product="uncharacterized protein C14orf93 isoform X1"
                     /calculated_mol_wt=58566
     Region          2..538
                     /region_name="DUF4616"
                     /note="Domain of unknown function (DUF4616); pfam15394"
                     /db_xref="CDD:464701"
     CDS             1..538
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
                     /coded_by="XM_005267972.3:261..1877"
                     /db_xref="GeneID:60686"
                     /db_xref="HGNC:HGNC:20162"
ORIGIN      
        1 msfsatilfs ppsgsearcc ccacksetng gntgsqggnp ppstpitvtg hglavqsseq
       61 llhviyqrvd kavglaeaal glarannell krlqeevgdl rqgkvsipde dgesrahssp
      121 peepgplkes pgeafkalsa veeecdsvgs gvqvvieelr qlgaasvgpg plgfpatqrd
      181 mrlpgctlaa seaapllnpl vddyvasega vqrvlvpaya kqlspatqla iqratpetgp
      241 engtklpppr pedmlnaaaa ldsaleesgp gstgelrhsl gltvspcrtr gsgqknsrrk
      301 rdlvlsklvh nvhnhitndk rfngsesiks swnisvvkfl leklkqelvt sphnytdkel
      361 kgacvayflt krreyrnsln pfkglkekee kklrsrryrl fanrssimrh fgpedqrlwn
      421 dvteelmsde edslnepgvw varpprfraq rltelcyhld anskhgtkan rvygppsdrl
      481 psaeaqllpp elynpnfqee edeggdenap gspsfdqphk tccpdlnsfi eikvekde
//
LOCUS       XP_047287621             538 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein C14orf93 isoform X1 [Homo sapiens].
ACCESSION   XP_047287621
VERSION     XP_047287621.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431665.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..538
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..538
                     /product="uncharacterized protein C14orf93 isoform X1"
                     /calculated_mol_wt=58566
     Region          2..538
                     /region_name="DUF4616"
                     /note="Domain of unknown function (DUF4616); pfam15394"
                     /db_xref="CDD:464701"
     CDS             1..538
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
                     /coded_by="XM_047431665.1:279..1895"
                     /db_xref="GeneID:60686"
                     /db_xref="HGNC:HGNC:20162"
ORIGIN      
        1 msfsatilfs ppsgsearcc ccacksetng gntgsqggnp ppstpitvtg hglavqsseq
       61 llhviyqrvd kavglaeaal glarannell krlqeevgdl rqgkvsipde dgesrahssp
      121 peepgplkes pgeafkalsa veeecdsvgs gvqvvieelr qlgaasvgpg plgfpatqrd
      181 mrlpgctlaa seaapllnpl vddyvasega vqrvlvpaya kqlspatqla iqratpetgp
      241 engtklpppr pedmlnaaaa ldsaleesgp gstgelrhsl gltvspcrtr gsgqknsrrk
      301 rdlvlsklvh nvhnhitndk rfngsesiks swnisvvkfl leklkqelvt sphnytdkel
      361 kgacvayflt krreyrnsln pfkglkekee kklrsrryrl fanrssimrh fgpedqrlwn
      421 dvteelmsde edslnepgvw varpprfraq rltelcyhld anskhgtkan rvygppsdrl
      481 psaeaqllpp elynpnfqee edeggdenap gspsfdqphk tccpdlnsfi eikvekde
//
LOCUS       XP_011535364             538 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein C14orf93 isoform X1 [Homo sapiens].
ACCESSION   XP_011535364
VERSION     XP_011535364.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537062.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..538
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..538
                     /product="uncharacterized protein C14orf93 isoform X1"
                     /calculated_mol_wt=58566
     Region          2..538
                     /region_name="DUF4616"
                     /note="Domain of unknown function (DUF4616); pfam15394"
                     /db_xref="CDD:464701"
     CDS             1..538
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
                     /coded_by="XM_011537062.3:3443..5059"
                     /db_xref="GeneID:60686"
                     /db_xref="HGNC:HGNC:20162"
ORIGIN      
        1 msfsatilfs ppsgsearcc ccacksetng gntgsqggnp ppstpitvtg hglavqsseq
       61 llhviyqrvd kavglaeaal glarannell krlqeevgdl rqgkvsipde dgesrahssp
      121 peepgplkes pgeafkalsa veeecdsvgs gvqvvieelr qlgaasvgpg plgfpatqrd
      181 mrlpgctlaa seaapllnpl vddyvasega vqrvlvpaya kqlspatqla iqratpetgp
      241 engtklpppr pedmlnaaaa ldsaleesgp gstgelrhsl gltvspcrtr gsgqknsrrk
      301 rdlvlsklvh nvhnhitndk rfngsesiks swnisvvkfl leklkqelvt sphnytdkel
      361 kgacvayflt krreyrnsln pfkglkekee kklrsrryrl fanrssimrh fgpedqrlwn
      421 dvteelmsde edslnepgvw varpprfraq rltelcyhld anskhgtkan rvygppsdrl
      481 psaeaqllpp elynpnfqee edeggdenap gspsfdqphk tccpdlnsfi eikvekde
//
LOCUS       XP_047287622             538 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein C14orf93 isoform X1 [Homo sapiens].
ACCESSION   XP_047287622
VERSION     XP_047287622.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431666.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..538
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..538
                     /product="uncharacterized protein C14orf93 isoform X1"
                     /calculated_mol_wt=58566
     Region          2..538
                     /region_name="DUF4616"
                     /note="Domain of unknown function (DUF4616); pfam15394"
                     /db_xref="CDD:464701"
     CDS             1..538
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
                     /coded_by="XM_047431666.1:340..1956"
                     /db_xref="GeneID:60686"
                     /db_xref="HGNC:HGNC:20162"
ORIGIN      
        1 msfsatilfs ppsgsearcc ccacksetng gntgsqggnp ppstpitvtg hglavqsseq
       61 llhviyqrvd kavglaeaal glarannell krlqeevgdl rqgkvsipde dgesrahssp
      121 peepgplkes pgeafkalsa veeecdsvgs gvqvvieelr qlgaasvgpg plgfpatqrd
      181 mrlpgctlaa seaapllnpl vddyvasega vqrvlvpaya kqlspatqla iqratpetgp
      241 engtklpppr pedmlnaaaa ldsaleesgp gstgelrhsl gltvspcrtr gsgqknsrrk
      301 rdlvlsklvh nvhnhitndk rfngsesiks swnisvvkfl leklkqelvt sphnytdkel
      361 kgacvayflt krreyrnsln pfkglkekee kklrsrryrl fanrssimrh fgpedqrlwn
      421 dvteelmsde edslnepgvw varpprfraq rltelcyhld anskhgtkan rvygppsdrl
      481 psaeaqllpp elynpnfqee edeggdenap gspsfdqphk tccpdlnsfi eikvekde
//
LOCUS       XP_016877059             538 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein C14orf93 isoform X1 [Homo sapiens].
ACCESSION   XP_016877059
VERSION     XP_016877059.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021570.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..538
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..538
                     /product="uncharacterized protein C14orf93 isoform X1"
                     /calculated_mol_wt=58566
     Region          2..538
                     /region_name="DUF4616"
                     /note="Domain of unknown function (DUF4616); pfam15394"
                     /db_xref="CDD:464701"
     CDS             1..538
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
                     /coded_by="XM_017021570.3:5538..7154"
                     /db_xref="GeneID:60686"
                     /db_xref="HGNC:HGNC:20162"
ORIGIN      
        1 msfsatilfs ppsgsearcc ccacksetng gntgsqggnp ppstpitvtg hglavqsseq
       61 llhviyqrvd kavglaeaal glarannell krlqeevgdl rqgkvsipde dgesrahssp
      121 peepgplkes pgeafkalsa veeecdsvgs gvqvvieelr qlgaasvgpg plgfpatqrd
      181 mrlpgctlaa seaapllnpl vddyvasega vqrvlvpaya kqlspatqla iqratpetgp
      241 engtklpppr pedmlnaaaa ldsaleesgp gstgelrhsl gltvspcrtr gsgqknsrrk
      301 rdlvlsklvh nvhnhitndk rfngsesiks swnisvvkfl leklkqelvt sphnytdkel
      361 kgacvayflt krreyrnsln pfkglkekee kklrsrryrl fanrssimrh fgpedqrlwn
      421 dvteelmsde edslnepgvw varpprfraq rltelcyhld anskhgtkan rvygppsdrl
      481 psaeaqllpp elynpnfqee edeggdenap gspsfdqphk tccpdlnsfi eikvekde
//
LOCUS       XP_016877064             358 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein C14orf93 isoform X2 [Homo sapiens].
ACCESSION   XP_016877064
VERSION     XP_016877064.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021575.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..358
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..358
                     /product="uncharacterized protein C14orf93 isoform X2"
                     /calculated_mol_wt=40005
     Region          <11..358
                     /region_name="DUF4616"
                     /note="Domain of unknown function (DUF4616); pfam15394"
                     /db_xref="CDD:464701"
     CDS             1..358
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
                     /coded_by="XM_017021575.3:6481..7557"
                     /db_xref="GeneID:60686"
                     /db_xref="HGNC:HGNC:20162"
ORIGIN      
        1 mrlpgctlaa seaapllnpl vddyvasega vqrvlvpaya kqlspatqla iqratpetgp
       61 engtklpppr pedmlnaaaa ldsaleesgp gstgelrhsl gltvspcrtr gsgqknsrrk
      121 rdlvlsklvh nvhnhitndk rfngsesiks swnisvvkfl leklkqelvt sphnytdkel
      181 kgacvayflt krreyrnsln pfkglkekee kklrsrryrl fanrssimrh fgpedqrlwn
      241 dvteelmsde edslnepgvw varpprfraq rltelcyhld anskhgtkan rvygppsdrl
      301 psaeaqllpp elynpnfqee edeggdenap gspsfdqphk tccpdlnsfi eikvekde
//
LOCUS       XP_047287623             358 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein C14orf93 isoform X2 [Homo sapiens].
ACCESSION   XP_047287623
VERSION     XP_047287623.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431667.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..358
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..358
                     /product="uncharacterized protein C14orf93 isoform X2"
                     /calculated_mol_wt=40005
     Region          <11..358
                     /region_name="DUF4616"
                     /note="Domain of unknown function (DUF4616); pfam15394"
                     /db_xref="CDD:464701"
     CDS             1..358
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
                     /coded_by="XM_047431667.1:5726..6802"
                     /db_xref="GeneID:60686"
                     /db_xref="HGNC:HGNC:20162"
ORIGIN      
        1 mrlpgctlaa seaapllnpl vddyvasega vqrvlvpaya kqlspatqla iqratpetgp
       61 engtklpppr pedmlnaaaa ldsaleesgp gstgelrhsl gltvspcrtr gsgqknsrrk
      121 rdlvlsklvh nvhnhitndk rfngsesiks swnisvvkfl leklkqelvt sphnytdkel
      181 kgacvayflt krreyrnsln pfkglkekee kklrsrryrl fanrssimrh fgpedqrlwn
      241 dvteelmsde edslnepgvw varpprfraq rltelcyhld anskhgtkan rvygppsdrl
      301 psaeaqllpp elynpnfqee edeggdenap gspsfdqphk tccpdlnsfi eikvekde
//
LOCUS       XP_047287624             358 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein C14orf93 isoform X2 [Homo sapiens].
ACCESSION   XP_047287624
VERSION     XP_047287624.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431668.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..358
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..358
                     /product="uncharacterized protein C14orf93 isoform X2"
                     /calculated_mol_wt=40005
     Region          <11..358
                     /region_name="DUF4616"
                     /note="Domain of unknown function (DUF4616); pfam15394"
                     /db_xref="CDD:464701"
     CDS             1..358
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
                     /coded_by="XM_047431668.1:5520..6596"
                     /db_xref="GeneID:60686"
                     /db_xref="HGNC:HGNC:20162"
ORIGIN      
        1 mrlpgctlaa seaapllnpl vddyvasega vqrvlvpaya kqlspatqla iqratpetgp
       61 engtklpppr pedmlnaaaa ldsaleesgp gstgelrhsl gltvspcrtr gsgqknsrrk
      121 rdlvlsklvh nvhnhitndk rfngsesiks swnisvvkfl leklkqelvt sphnytdkel
      181 kgacvayflt krreyrnsln pfkglkekee kklrsrryrl fanrssimrh fgpedqrlwn
      241 dvteelmsde edslnepgvw varpprfraq rltelcyhld anskhgtkan rvygppsdrl
      301 psaeaqllpp elynpnfqee edeggdenap gspsfdqphk tccpdlnsfi eikvekde
//
LOCUS       XP_047287625             358 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein C14orf93 isoform X2 [Homo sapiens].
ACCESSION   XP_047287625
VERSION     XP_047287625.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431669.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..358
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..358
                     /product="uncharacterized protein C14orf93 isoform X2"
                     /calculated_mol_wt=40005
     Region          <11..358
                     /region_name="DUF4616"
                     /note="Domain of unknown function (DUF4616); pfam15394"
                     /db_xref="CDD:464701"
     CDS             1..358
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
                     /coded_by="XM_047431669.1:568..1644"
                     /db_xref="GeneID:60686"
                     /db_xref="HGNC:HGNC:20162"
ORIGIN      
        1 mrlpgctlaa seaapllnpl vddyvasega vqrvlvpaya kqlspatqla iqratpetgp
       61 engtklpppr pedmlnaaaa ldsaleesgp gstgelrhsl gltvspcrtr gsgqknsrrk
      121 rdlvlsklvh nvhnhitndk rfngsesiks swnisvvkfl leklkqelvt sphnytdkel
      181 kgacvayflt krreyrnsln pfkglkekee kklrsrryrl fanrssimrh fgpedqrlwn
      241 dvteelmsde edslnepgvw varpprfraq rltelcyhld anskhgtkan rvygppsdrl
      301 psaeaqllpp elynpnfqee edeggdenap gspsfdqphk tccpdlnsfi eikvekde
//
LOCUS       XP_006720295             358 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein C14orf93 isoform X2 [Homo sapiens].
ACCESSION   XP_006720295
VERSION     XP_006720295.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720232.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..358
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..358
                     /product="uncharacterized protein C14orf93 isoform X2"
                     /calculated_mol_wt=40005
     Region          <11..358
                     /region_name="DUF4616"
                     /note="Domain of unknown function (DUF4616); pfam15394"
                     /db_xref="CDD:464701"
     CDS             1..358
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
                     /coded_by="XM_006720232.3:484..1560"
                     /db_xref="GeneID:60686"
                     /db_xref="HGNC:HGNC:20162"
ORIGIN      
        1 mrlpgctlaa seaapllnpl vddyvasega vqrvlvpaya kqlspatqla iqratpetgp
       61 engtklpppr pedmlnaaaa ldsaleesgp gstgelrhsl gltvspcrtr gsgqknsrrk
      121 rdlvlsklvh nvhnhitndk rfngsesiks swnisvvkfl leklkqelvt sphnytdkel
      181 kgacvayflt krreyrnsln pfkglkekee kklrsrryrl fanrssimrh fgpedqrlwn
      241 dvteelmsde edslnepgvw varpprfraq rltelcyhld anskhgtkan rvygppsdrl
      301 psaeaqllpp elynpnfqee edeggdenap gspsfdqphk tccpdlnsfi eikvekde
//
LOCUS       XP_006720294             358 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein C14orf93 isoform X2 [Homo sapiens].
ACCESSION   XP_006720294
VERSION     XP_006720294.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720231.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..358
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..358
                     /product="uncharacterized protein C14orf93 isoform X2"
                     /calculated_mol_wt=40005
     Region          <11..358
                     /region_name="DUF4616"
                     /note="Domain of unknown function (DUF4616); pfam15394"
                     /db_xref="CDD:464701"
     CDS             1..358
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
                     /coded_by="XM_006720231.2:489..1565"
                     /db_xref="GeneID:60686"
                     /db_xref="HGNC:HGNC:20162"
ORIGIN      
        1 mrlpgctlaa seaapllnpl vddyvasega vqrvlvpaya kqlspatqla iqratpetgp
       61 engtklpppr pedmlnaaaa ldsaleesgp gstgelrhsl gltvspcrtr gsgqknsrrk
      121 rdlvlsklvh nvhnhitndk rfngsesiks swnisvvkfl leklkqelvt sphnytdkel
      181 kgacvayflt krreyrnsln pfkglkekee kklrsrryrl fanrssimrh fgpedqrlwn
      241 dvteelmsde edslnepgvw varpprfraq rltelcyhld anskhgtkan rvygppsdrl
      301 psaeaqllpp elynpnfqee edeggdenap gspsfdqphk tccpdlnsfi eikvekde
//
LOCUS       XP_047287627             358 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein C14orf93 isoform X2 [Homo sapiens].
ACCESSION   XP_047287627
VERSION     XP_047287627.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431671.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..358
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..358
                     /product="uncharacterized protein C14orf93 isoform X2"
                     /calculated_mol_wt=40005
     Region          <11..358
                     /region_name="DUF4616"
                     /note="Domain of unknown function (DUF4616); pfam15394"
                     /db_xref="CDD:464701"
     CDS             1..358
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
                     /coded_by="XM_047431671.1:507..1583"
                     /db_xref="GeneID:60686"
                     /db_xref="HGNC:HGNC:20162"
ORIGIN      
        1 mrlpgctlaa seaapllnpl vddyvasega vqrvlvpaya kqlspatqla iqratpetgp
       61 engtklpppr pedmlnaaaa ldsaleesgp gstgelrhsl gltvspcrtr gsgqknsrrk
      121 rdlvlsklvh nvhnhitndk rfngsesiks swnisvvkfl leklkqelvt sphnytdkel
      181 kgacvayflt krreyrnsln pfkglkekee kklrsrryrl fanrssimrh fgpedqrlwn
      241 dvteelmsde edslnepgvw varpprfraq rltelcyhld anskhgtkan rvygppsdrl
      301 psaeaqllpp elynpnfqee edeggdenap gspsfdqphk tccpdlnsfi eikvekde
//
LOCUS       XP_047287628             358 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein C14orf93 isoform X2 [Homo sapiens].
ACCESSION   XP_047287628
VERSION     XP_047287628.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431672.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..358
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..358
                     /product="uncharacterized protein C14orf93 isoform X2"
                     /calculated_mol_wt=40005
     Region          <11..358
                     /region_name="DUF4616"
                     /note="Domain of unknown function (DUF4616); pfam15394"
                     /db_xref="CDD:464701"
     CDS             1..358
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
                     /coded_by="XM_047431672.1:405..1481"
                     /db_xref="GeneID:60686"
                     /db_xref="HGNC:HGNC:20162"
ORIGIN      
        1 mrlpgctlaa seaapllnpl vddyvasega vqrvlvpaya kqlspatqla iqratpetgp
       61 engtklpppr pedmlnaaaa ldsaleesgp gstgelrhsl gltvspcrtr gsgqknsrrk
      121 rdlvlsklvh nvhnhitndk rfngsesiks swnisvvkfl leklkqelvt sphnytdkel
      181 kgacvayflt krreyrnsln pfkglkekee kklrsrryrl fanrssimrh fgpedqrlwn
      241 dvteelmsde edslnepgvw varpprfraq rltelcyhld anskhgtkan rvygppsdrl
      301 psaeaqllpp elynpnfqee edeggdenap gspsfdqphk tccpdlnsfi eikvekde
//
LOCUS       XP_016877065             358 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein C14orf93 isoform X2 [Homo sapiens].
ACCESSION   XP_016877065
VERSION     XP_016877065.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021576.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..358
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..358
                     /product="uncharacterized protein C14orf93 isoform X2"
                     /calculated_mol_wt=40005
     Region          <11..358
                     /region_name="DUF4616"
                     /note="Domain of unknown function (DUF4616); pfam15394"
                     /db_xref="CDD:464701"
     CDS             1..358
                     /gene="C14orf93"
                     /gene_synonym="RTFC"
                     /coded_by="XM_017021576.2:730..1806"
                     /db_xref="GeneID:60686"
                     /db_xref="HGNC:HGNC:20162"
ORIGIN      
        1 mrlpgctlaa seaapllnpl vddyvasega vqrvlvpaya kqlspatqla iqratpetgp
       61 engtklpppr pedmlnaaaa ldsaleesgp gstgelrhsl gltvspcrtr gsgqknsrrk
      121 rdlvlsklvh nvhnhitndk rfngsesiks swnisvvkfl leklkqelvt sphnytdkel
      181 kgacvayflt krreyrnsln pfkglkekee kklrsrryrl fanrssimrh fgpedqrlwn
      241 dvteelmsde edslnepgvw varpprfraq rltelcyhld anskhgtkan rvygppsdrl
      301 psaeaqllpp elynpnfqee edeggdenap gspsfdqphk tccpdlnsfi eikvekde
//
LOCUS       XP_011535365             620 aa            linear   PRI 05-AUG-2025
DEFINITION  reticulon-1 isoform X1 [Homo sapiens].
ACCESSION   XP_011535365
VERSION     XP_011535365.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537063.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..620
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..620
                     /product="reticulon-1 isoform X1"
                     /calculated_mol_wt=65878
     CDS             1..620
                     /gene="RTN1"
                     /gene_synonym="NSP"
                     /coded_by="XM_011537063.4:147..2009"
                     /db_xref="GeneID:6252"
                     /db_xref="HGNC:HGNC:10467"
                     /db_xref="MIM:600865"
ORIGIN      
        1 maapgdpqde llplagpgsq wlrhrgegen eavtpkgatp apqagepspg lgarareaas
       61 reagsgparq spvametast gvagvssamd htfsttskdg egscytslis dicyppqeds
      121 tyftgilqke nghvtisesp eelgtpgpsl pdvpgiesrg lfssdsgiem tpaestevnk
      181 iladpldqmk aeaykyidit rpeevkhqeq hhpeledkdl dfknkdtdis ikpegvrepd
      241 kpapvegkii kdhlleestf apyiddlsee qrrapqittp vkitlteiep svetttqekt
      301 pekqdiclkp spdtvptvtv sepeddspgs itppssgtep saaesqgkgs isedelitai
      361 keakglsyet aenprpvgql adrpevkars gpptipspld heassaesgd seielvsedp
      421 maaedalpsg yvsfghvggp ppspaspsiq ysilreerea eldseliies cdassasees
      481 pkreqdsppm kpsaldaire etgvraeera psrrglaepg sfldypstep qpgpelppgd
      541 galepetpml prkpeedsss nqspaatkgp gplgpgappp llflnkqkdi irvqeilpqk
      601 sftapdcscl mefkkgirvt
//
LOCUS       XP_047287630             600 aa            linear   PRI 05-AUG-2025
DEFINITION  reticulon-1 isoform X2 [Homo sapiens].
ACCESSION   XP_047287630
VERSION     XP_047287630.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431674.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..600
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..600
                     /product="reticulon-1 isoform X2"
                     /calculated_mol_wt=63591
     CDS             1..600
                     /gene="RTN1"
                     /gene_synonym="NSP"
                     /coded_by="XM_047431674.1:147..1949"
                     /db_xref="GeneID:6252"
                     /db_xref="HGNC:HGNC:10467"
                     /db_xref="MIM:600865"
ORIGIN      
        1 maapgdpqde llplagpgsq wlrhrgegen eavtpkgatp apqagepspg lgarareaas
       61 reagsgparq spvametast gvagvssamd htfsttskdg egscytslis dicyppqeds
      121 tyftgilqke nghvtisesp eelgtpgpsl pdvpgiesrg lfssdsgiem tpaestevnk
      181 iladpldqmk aeaykyidit rpeevkhqeq hhpeledkdl dfknkdtdis ikpegvrepd
      241 kpapvegkii kdhlleestf apyiddlsee qrrapqittp vkitlteiep svetttqekt
      301 pekqdiclkp spdtvptvtv sepeddspgs itppssgtep saaesqgkgs isedelitai
      361 keakglsyet aenprpvgql adrpevkars gpptipspld heassaesgd seielvsedp
      421 maaedalpsg yvsfghvggp ppspaspsiq ysilreerea eldseliies cdassasees
      481 pkreqdsppm kpsaldaire etgvraeera psrrglaepg sfldypstep qpgpelppgd
      541 galepetpml prkpeedsss nqspaatkgp gplgpgappp llflnkqkgv rfhlssmplh
//
LOCUS       XP_011535366            1043 aa            linear   PRI 05-AUG-2025
DEFINITION  sal-like protein 2 isoform X1 [Homo sapiens].
ACCESSION   XP_011535366
VERSION     XP_011535366.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537064.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1043
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1043
                     /product="sal-like protein 2 isoform X1"
                     /calculated_mol_wt=109187
     Region          372..459
                     /region_name="SUF4-like"
                     /note="N-terminal domain of Oryza sativa transcription
                     factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana
                     SUF4 (AtSUF4), and similar proteins; cd20908"
                     /db_xref="CDD:411020"
     Region          375..396
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:411020"
     Region          375..395
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(380,386,393,395,402,409)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:411020"
     Region          403..423
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:411020"
     Region          403..423
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          633..653
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(638,640,642,644..645,648..649,652,666,668,672..673,
                     676..677,680,698,700,702,704..705,708..709,712)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          659..681
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          661..681
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          692..713
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          693..713
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          913..933
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275370"
     Region          913..933
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Site            order(918,920,922,924..925,928..929,932,947,949..951,
                     953..954,958)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275370"
     Region          942..959
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275370"
     CDS             1..1043
                     /gene="SALL2"
                     /gene_synonym="COLB; HSAL2; p150(Sal2); Sal-2; ZNF795"
                     /coded_by="XM_011537064.2:201..3332"
                     /db_xref="GeneID:6297"
                     /db_xref="HGNC:HGNC:10526"
                     /db_xref="MIM:602219"
ORIGIN      
        1 msrrkqrkpq qlisdcegps asengdasee dhpqvcakcc aqftdptefl ahqnacstdp
       61 pvmviiggqe npnnssasse prpeghnnpq vmdtehsnpp dsgssvptdp twgperrgee
      121 ssghflvaat gtaagggggl ilaspklgat plppestpap pppppppppp gvgsghlnip
      181 lileelrvlq qrqihqmqmt eqicrqvlll gslgqtvgap aspselpgtg tasstkpllp
      241 lfspikpvqt sktlasssss sssssgaetp kqaffhlyhp lgsqhpfsag gvgrshkptp
      301 apspalpgst dqliasphla fpsttgllaa qclgaargle ataspgllkp kngsgelsyg
      361 evmgplekpg grhkcrfcak vfgsdsalqi hlrshtgerp ykcnvcgnrf ttrgnlkvhf
      421 hrhrekyphv qmnphpvpeh ldyvitssgl pygmsvppek aeeeaatpgg gverkplvas
      481 ttalsatesl tllstsagta tapglpafnk fvlmkavepk nkadentppg segsaisgva
      541 esstatrmql sklvtslpsw alltnhfkst gsfpfpyvle plgaspsets klqqlvekid
      601 rqgavavtsa asgapttsap apsssassgp nqcviclrvl scpralrlhy gqhggerpfk
      661 ckvcgrafst rgnlrahfvg hkaspaaraq nscpicqkkf tnavtlqqhv rmhlggqipn
      721 ggtalpeggg aaqengseqs tvsgarsfpq qqsqqpspee elseeeeeed eeeeedvtde
      781 dslagrgses ggekaisvrg dseeasgaee evgtvaaaat agkemdsnek ttqqsslppp
      841 pppdsldqpq pmeqgssgvl ggkeeggkpe rssspasalt pegeatsvtl veelslqeam
      901 rkepgesssr kacevcgqaf psqaaleehq kthpkegplf tcvfcrqgfl eratlkkhml
      961 lahhqnqyva flsnglpmkp wnssststtt pslappvlfg lgtvagkvpp tmgsreakek
     1021 tapllfqppa pkavpekpii dkk
//
LOCUS       XP_011535367            1041 aa            linear   PRI 05-AUG-2025
DEFINITION  sal-like protein 2 isoform X2 [Homo sapiens].
ACCESSION   XP_011535367
VERSION     XP_011535367.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537065.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1041
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1041
                     /product="sal-like protein 2 isoform X2"
                     /calculated_mol_wt=108753
     Region          370..457
                     /region_name="SUF4-like"
                     /note="N-terminal domain of Oryza sativa transcription
                     factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana
                     SUF4 (AtSUF4), and similar proteins; cd20908"
                     /db_xref="CDD:411020"
     Region          373..394
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:411020"
     Region          373..393
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(378,384,391,393,400,407)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:411020"
     Region          401..421
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:411020"
     Region          401..421
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          631..651
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(636,638,640,642..643,646..647,650,664,666,670..671,
                     674..675,678,696,698,700,702..703,706..707,710)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          657..679
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          659..679
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          690..711
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          691..711
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          911..931
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275370"
     Region          911..931
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Site            order(916,918,920,922..923,926..927,930,945,947..949,
                     951..952,956)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275370"
     Region          940..957
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275370"
     CDS             1..1041
                     /gene="SALL2"
                     /gene_synonym="COLB; HSAL2; p150(Sal2); Sal-2; ZNF795"
                     /coded_by="XM_011537065.3:220..3345"
                     /db_xref="GeneID:6297"
                     /db_xref="HGNC:HGNC:10526"
                     /db_xref="MIM:602219"
ORIGIN      
        1 maheserssr lgvpcgepae lggdaseedh pqvcakccaq ftdpteflah qnacstdppv
       61 mviiggqenp nnssassepr peghnnpqvm dtehsnppds gssvptdptw gperrgeess
      121 ghflvaatgt aaggggglil aspklgatpl ppestpappp ppppppppgv gsghlnipli
      181 leelrvlqqr qihqmqmteq icrqvlllgs lgqtvgapas pselpgtgta sstkpllplf
      241 spikpvqtsk tlasssssss sssgaetpkq affhlyhplg sqhpfsaggv grshkptpap
      301 spalpgstdq liasphlafp sttgllaaqc lgaargleat aspgllkpkn gsgelsygev
      361 mgplekpggr hkcrfcakvf gsdsalqihl rshtgerpyk cnvcgnrftt rgnlkvhfhr
      421 hrekyphvqm nphpvpehld yvitssglpy gmsvppekae eeaatpgggv erkplvastt
      481 alsatesltl lstsagtata pglpafnkfv lmkavepknk adentppgse gsaisgvaes
      541 statrmqlsk lvtslpswal ltnhfkstgs fpfpyvlepl gaspsetskl qqlvekidrq
      601 gavavtsaas gapttsapap sssassgpnq cviclrvlsc pralrlhygq hggerpfkck
      661 vcgrafstrg nlrahfvghk aspaaraqns cpicqkkftn avtlqqhvrm hlggqipngg
      721 talpegggaa qengseqstv sgarsfpqqq sqqpspeeel seeeeeedee eeedvtdeds
      781 lagrgsesgg ekaisvrgds eeasgaeeev gtvaaaatag kemdsnektt qqsslppppp
      841 pdsldqpqpm eqgssgvlgg keeggkpers sspasaltpe geatsvtlve elslqeamrk
      901 epgesssrka cevcgqafps qaaleehqkt hpkegplftc vfcrqgfler atlkkhmlla
      961 hhqnqyvafl snglpmkpwn ssststttps lappvlfglg tvagkvpptm gsreakekta
     1021 pllfqppapk avpekpiidk k
//
LOCUS       XP_016877070             409 aa            linear   PRI 05-AUG-2025
DEFINITION  spermatogenesis-defective protein 39 homolog isoform X1 [Homo
            sapiens].
ACCESSION   XP_016877070
VERSION     XP_016877070.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021581.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..409
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..409
                     /product="spermatogenesis-defective protein 39 homolog
                     isoform X1"
                     /calculated_mol_wt=46871
     CDS             1..409
                     /gene="VIPAS39"
                     /gene_synonym="C14orf133; hSPE-39; SPE-39; SPE39; VIPAR;
                     VPS16B"
                     /coded_by="XM_017021581.3:379..1608"
                     /db_xref="GeneID:63894"
                     /db_xref="HGNC:HGNC:20347"
                     /db_xref="MIM:613401"
ORIGIN      
        1 mnrtkgdeee ywnsskfkaf tfddeddels qlkeskravn slrdfvdddd dddlervsws
       61 gepvgsisws iretagnsgs thegreqlks rnsfssyaql pkptstysls sffrgrtrpg
      121 sfqslsdals dtpaksyape lgrpkgeyrd ysndwspsdt vrrlrkgkvc slerfrslqd
      181 klqlleeavs mhdgnvitav liflkrtlsk eilfrelevr qvalrhlihf lkeigdqkll
      241 ldlfrfldrt eelalshyre hlniqdpdkr keflktcvgl pfsaedsahi qdhytllerq
      301 iiieandrhl esagqteifr khprkasiln mplvttlfys cfyhyteaeg tfsspvnlkk
      361 tfkipdkqyv ltalaarakl rawndvdalf ttkantvksl mgsfpdlps
//
LOCUS       XP_005268045             773 aa            linear   PRI 05-AUG-2025
DEFINITION  protein sel-1 homolog 1 isoform X1 [Homo sapiens].
ACCESSION   XP_005268045
VERSION     XP_005268045.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267988.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..773
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..773
                     /product="protein sel-1 homolog 1 isoform X1"
                     /calculated_mol_wt=86370
     Region          <115..147
                     /region_name="FN2"
                     /note="Fibronectin type 2 domain; smart00059"
                     /db_xref="CDD:128373"
     Region          184..210
                     /region_name="SLR repeat"
                     /note="SLR repeat [structural motif]"
                     /db_xref="CDD:276807"
     Region          217..246
                     /region_name="SLR repeat"
                     /note="SLR repeat [structural motif]"
                     /db_xref="CDD:276807"
     Region          234..269
                     /region_name="SEL1"
                     /note="Sel1-like repeats; smart00671"
                     /db_xref="CDD:214772"
     Region          253..282
                     /region_name="SLR repeat"
                     /note="SLR repeat [structural motif]"
                     /db_xref="CDD:276807"
     Region          <340..492
                     /region_name="TPR"
                     /note="TPR repeat [General function prediction only];
                     COG0790"
                     /db_xref="CDD:440553"
     Region          372..401
                     /region_name="SLR repeat"
                     /note="SLR repeat [structural motif]"
                     /db_xref="CDD:276807"
     Region          409..438
                     /region_name="SLR repeat"
                     /note="SLR repeat [structural motif]"
                     /db_xref="CDD:276807"
     Region          445..687
                     /region_name="LapB"
                     /note="Lipopolysaccharide biosynthesis regulator
                     YciM/LapB, contains six TPR domains and a C-terminal
                     metal-binding domain [Cell wall/membrane/envelope
                     biogenesis]; COG2956"
                     /db_xref="CDD:442196"
     Region          445..474
                     /region_name="SLR repeat"
                     /note="SLR repeat [structural motif]"
                     /db_xref="CDD:276807"
     Region          549..578
                     /region_name="SLR repeat"
                     /note="SLR repeat [structural motif]"
                     /db_xref="CDD:276807"
     Region          589..618
                     /region_name="SLR repeat"
                     /note="SLR repeat [structural motif]"
                     /db_xref="CDD:276807"
     Region          608..641
                     /region_name="SEL1"
                     /note="Sel1-like repeats; smart00671"
                     /db_xref="CDD:214772"
     Region          625..655
                     /region_name="SLR repeat"
                     /note="SLR repeat [structural motif]"
                     /db_xref="CDD:276807"
     Region          643..676
                     /region_name="Sel1"
                     /note="Sel1 repeat; pfam08238"
                     /db_xref="CDD:429881"
     CDS             1..773
                     /gene="SEL1L"
                     /gene_synonym="Hrd3; NEDGSAF; NEDHGFA; PRO1063; SEL1-LIKE;
                     SEL1L1"
                     /coded_by="XM_005267988.4:110..2431"
                     /db_xref="GeneID:6400"
                     /db_xref="HGNC:HGNC:10717"
                     /db_xref="MIM:602329"
ORIGIN      
        1 mrvrigltll lcavllslas assdeegsqd esldskttlt sdesvkdhtt agrvvagqif
       61 ldseeseles siqeeedslk sqegesvted isflespnpe nkdyeepkkv rkpdkeydec
      121 tsdgredgrl wcattydyka dekwgfcete eeaakrrqmq eaemmyqtgm kilngsnkks
      181 qkreayrylq kaasmnhtka lervsyallf gdylpqniqa aremfeklte egspkgqtal
      241 gflyasglgv nssqakalvy ytfgalggnl iahmvlgyry wagigvlqsc esalthyrlv
      301 anhvasdisl tggsvvqrir lpdevenpgm nsgmleedli qyyqflaekg dvqaqvglgq
      361 lhlhggrgve qnhqrafdyf nlaanagnsh amaflgkmys egsdivpqsn etalhyfkka
      421 admgnpvgqs glgmaylygr gvqvnydlal kyfqkaaeqg wvdgqlqlgs myyngigvkr
      481 dykqalkyfn lasqgghila fynlaqmhas gtgvmrscht avelfknvce rgrwserlmt
      541 aynsykdgdy naaviqylll aeqgyevaqs naafildqre asivgenety prallhwnra
      601 asqgytvari klgdyhfygf gtdvdyetaf ihyrlaseqq hsaqamfnlg ymhekglgik
      661 qdihlakrfy dmaaeaspda qvpvflalck lgvvyflqyi retnirdmft qldmdqllgp
      721 ewdlylmtii alllgtviay rqrqhqdmpa prppgprpap pqqegppeqq ppq
//
LOCUS       XP_005268046             771 aa            linear   PRI 05-AUG-2025
DEFINITION  protein sel-1 homolog 1 isoform X2 [Homo sapiens].
ACCESSION   XP_005268046
VERSION     XP_005268046.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267989.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..771
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..771
                     /product="protein sel-1 homolog 1 isoform X2"
                     /calculated_mol_wt=86155
     Region          120..168
                     /region_name="FN2"
                     /note="Fibronectin type 2 domain; smart00059"
                     /db_xref="CDD:128373"
     Site            order(131,133,138,152,159,165,167)
                     /site_type="active"
                     /note="putative gelatin-binding site [active]"
                     /db_xref="CDD:238019"
     Region          <186..324
                     /region_name="TPR"
                     /note="TPR repeat [General function prediction only];
                     COG0790"
                     /db_xref="CDD:440553"
     Region          205..231
                     /region_name="SLR repeat"
                     /note="SLR repeat [structural motif]"
                     /db_xref="CDD:276807"
     Region          238..267
                     /region_name="SLR repeat"
                     /note="SLR repeat [structural motif]"
                     /db_xref="CDD:276807"
     Region          274..303
                     /region_name="SLR repeat"
                     /note="SLR repeat [structural motif]"
                     /db_xref="CDD:276807"
     Region          358..385
                     /region_name="SLR repeat"
                     /note="SLR repeat [structural motif]"
                     /db_xref="CDD:276807"
     Region          <361..529
                     /region_name="TPR"
                     /note="TPR repeat [General function prediction only];
                     COG0790"
                     /db_xref="CDD:440553"
     Region          407..436
                     /region_name="SLR repeat"
                     /note="SLR repeat [structural motif]"
                     /db_xref="CDD:276807"
     Region          443..472
                     /region_name="SLR repeat"
                     /note="SLR repeat [structural motif]"
                     /db_xref="CDD:276807"
     Region          479..508
                     /region_name="SLR repeat"
                     /note="SLR repeat [structural motif]"
                     /db_xref="CDD:276807"
     Region          547..576
                     /region_name="SLR repeat"
                     /note="SLR repeat [structural motif]"
                     /db_xref="CDD:276807"
     Region          587..616
                     /region_name="SLR repeat"
                     /note="SLR repeat [structural motif]"
                     /db_xref="CDD:276807"
     Region          606..639
                     /region_name="SEL1"
                     /note="Sel1-like repeats; smart00671"
                     /db_xref="CDD:214772"
     Region          623..653
                     /region_name="SLR repeat"
                     /note="SLR repeat [structural motif]"
                     /db_xref="CDD:276807"
     Region          641..674
                     /region_name="Sel1"
                     /note="Sel1 repeat; pfam08238"
                     /db_xref="CDD:429881"
     CDS             1..771
                     /gene="SEL1L"
                     /gene_synonym="Hrd3; NEDGSAF; NEDHGFA; PRO1063; SEL1-LIKE;
                     SEL1L1"
                     /coded_by="XM_005267989.5:110..2425"
                     /db_xref="GeneID:6400"
                     /db_xref="HGNC:HGNC:10717"
                     /db_xref="MIM:602329"
ORIGIN      
        1 mrvrigltll lcavllslas assdeegsqd esldskttlt sdesvkdhtt agrvvagqif
       61 ldseeseles siqeeedslk sqegesvted isflespnpe nkdyeepkkv rkpaltaieg
      121 tahgepchfp flfldkeyde ctsdgredgr lwcattydyk adekwgfcet eeeaakrrqm
      181 qeaemmyqtg mkilngsnkk sqkreayryl qkaasmnhtk alervsyall fgdylpqniq
      241 aaremfeklt eegspkgqta lgflyasglg vnssqakalv yytfgalggn liahmvlgyr
      301 ywagigvlqs cesalthyrl vanhvasdis ltggsvvqri rlpdevenpg mnsgmleedl
      361 iqyyqflaek gdvqaqvglg qlhlhggrgv eqnhqmyseg sdivpqsnet alhyfkkaad
      421 mgnpvgqsgl gmaylygrgv qvnydlalky fqkaaeqgwv dgqlqlgsmy yngigvkrdy
      481 kqalkyfnla sqgghilafy nlaqmhasgt gvmrschtav elfknvcerg rwserlmtay
      541 nsykdgdyna aviqylllae qgyevaqsna afildqreas ivgenetypr allhwnraas
      601 qgytvarikl gdyhfygfgt dvdyetafih yrlaseqqhs aqamfnlgym hekglgikqd
      661 ihlakrfydm aaeaspdaqv pvflalcklg vvyflqyire tnirdmftql dmdqllgpew
      721 dlylmtiial llgtviayrq rqhqdmpapr ppgprpappq qegppeqqpp q
//
LOCUS       XP_047287632             750 aa            linear   PRI 05-AUG-2025
DEFINITION  protein sel-1 homolog 1 isoform X3 [Homo sapiens].
ACCESSION   XP_047287632
VERSION     XP_047287632.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431676.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..750
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..750
                     /product="protein sel-1 homolog 1 isoform X3"
                     /calculated_mol_wt=83902
     Region          <115..147
                     /region_name="FN2"
                     /note="Fibronectin type 2 domain; smart00059"
                     /db_xref="CDD:128373"
     Region          <165..303
                     /region_name="TPR"
                     /note="TPR repeat [General function prediction only];
                     COG0790"
                     /db_xref="CDD:440553"
     Region          184..210
                     /region_name="SLR repeat"
                     /note="SLR repeat [structural motif]"
                     /db_xref="CDD:276807"
     Region          217..246
                     /region_name="SLR repeat"
                     /note="SLR repeat [structural motif]"
                     /db_xref="CDD:276807"
     Region          253..282
                     /region_name="SLR repeat"
                     /note="SLR repeat [structural motif]"
                     /db_xref="CDD:276807"
     Region          337..364
                     /region_name="SLR repeat"
                     /note="SLR repeat [structural motif]"
                     /db_xref="CDD:276807"
     Region          <340..508
                     /region_name="TPR"
                     /note="TPR repeat [General function prediction only];
                     COG0790"
                     /db_xref="CDD:440553"
     Region          386..415
                     /region_name="SLR repeat"
                     /note="SLR repeat [structural motif]"
                     /db_xref="CDD:276807"
     Region          422..451
                     /region_name="SLR repeat"
                     /note="SLR repeat [structural motif]"
                     /db_xref="CDD:276807"
     Region          458..487
                     /region_name="SLR repeat"
                     /note="SLR repeat [structural motif]"
                     /db_xref="CDD:276807"
     Region          526..555
                     /region_name="SLR repeat"
                     /note="SLR repeat [structural motif]"
                     /db_xref="CDD:276807"
     Region          566..595
                     /region_name="SLR repeat"
                     /note="SLR repeat [structural motif]"
                     /db_xref="CDD:276807"
     Region          585..618
                     /region_name="SEL1"
                     /note="Sel1-like repeats; smart00671"
                     /db_xref="CDD:214772"
     Region          602..632
                     /region_name="SLR repeat"
                     /note="SLR repeat [structural motif]"
                     /db_xref="CDD:276807"
     Region          620..653
                     /region_name="Sel1"
                     /note="Sel1 repeat; pfam08238"
                     /db_xref="CDD:429881"
     CDS             1..750
                     /gene="SEL1L"
                     /gene_synonym="Hrd3; NEDGSAF; NEDHGFA; PRO1063; SEL1-LIKE;
                     SEL1L1"
                     /coded_by="XM_047431676.1:110..2362"
                     /db_xref="GeneID:6400"
                     /db_xref="HGNC:HGNC:10717"
                     /db_xref="MIM:602329"
ORIGIN      
        1 mrvrigltll lcavllslas assdeegsqd esldskttlt sdesvkdhtt agrvvagqif
       61 ldseeseles siqeeedslk sqegesvted isflespnpe nkdyeepkkv rkpdkeydec
      121 tsdgredgrl wcattydyka dekwgfcete eeaakrrqmq eaemmyqtgm kilngsnkks
      181 qkreayrylq kaasmnhtka lervsyallf gdylpqniqa aremfeklte egspkgqtal
      241 gflyasglgv nssqakalvy ytfgalggnl iahmvlgyry wagigvlqsc esalthyrlv
      301 anhvasdisl tggsvvqrir lpdevenpgm nsgmleedli qyyqflaekg dvqaqvglgq
      361 lhlhggrgve qnhqmysegs divpqsneta lhyfkkaadm gnpvgqsglg maylygrgvq
      421 vnydlalkyf qkaaeqgwvd gqlqlgsmyy ngigvkrdyk qalkyfnlas qgghilafyn
      481 laqmhasgtg vmrschtave lfknvcergr wserlmtayn sykdgdynaa viqylllaeq
      541 gyevaqsnaa fildqreasi vgenetypra llhwnraasq gytvariklg dyhfygfgtd
      601 vdyetafihy rlaseqqhsa qamfnlgymh ekglgikqdi hlakrfydma aeaspdaqvp
      661 vflalcklgv vyflqyiret nirdmftqld mdqllgpewd lylmtiiall lgtviayrqr
      721 qhqdmpaprp pgprpappqq egppeqqppq
//
LOCUS       XP_016877071             986 aa            linear   PRI 05-AUG-2025
DEFINITION  neuronal PAS domain-containing protein 3 isoform X1 [Homo sapiens].
ACCESSION   XP_016877071
VERSION     XP_016877071.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021582.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..986
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..986
                     /product="neuronal PAS domain-containing protein 3 isoform
                     X1"
                     /calculated_mol_wt=105799
     Region          84..160
                     /region_name="bHLH-PAS_NPAS3_PASD6"
                     /note="basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS)
                     domain found in neuronal PAS domain-containing protein 3
                     (NPAS3) and similar proteins; cd19732"
                     /db_xref="CDD:381575"
     Site            order(89,91..93,97,99..100,104,125..126)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381575"
     Site            order(99,102..103,106,109..110,113,115..116,127,130..132,
                     134,136..140)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:381575"
     Region          205..263
                     /region_name="PAS"
                     /note="PAS domain; smart00091"
                     /db_xref="CDD:214512"
     Region          207..>466
                     /region_name="KinE"
                     /note="Sporulation sensor histidine kinase E [Cell cycle
                     control, cell division, chromosome partitioning, Signal
                     transduction mechanisms]; COG5809"
                     /db_xref="CDD:444511"
     Region          396..483
                     /region_name="PAS_3"
                     /note="PAS fold; pfam08447"
                     /db_xref="CDD:430001"
     Site            order(399,403,409,422..425,451,456)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:238075"
     Site            order(419,423,431,434..435,463,465)
                     /site_type="other"
                     /note="heme pocket [chemical binding]"
                     /db_xref="CDD:238075"
     Region          <489..>648
                     /region_name="MSCRAMM_ClfA"
                     /note="MSCRAMM family adhesin clumping factor ClfA;
                     NF033609"
                     /db_xref="CDD:468110"
     CDS             1..986
                     /gene="NPAS3"
                     /gene_synonym="bHLHe12; MOP6; PASD6"
                     /coded_by="XM_017021582.2:62..3022"
                     /db_xref="GeneID:64067"
                     /db_xref="HGNC:HGNC:19311"
                     /db_xref="MIM:609430"
ORIGIN      
        1 mirifpdfsv qvtaaaagga aagvpagagm gragaaangt pqnvqgitsy qqritaqhpl
       61 pnqsecrkiy rydgiycest yqnlqalrke ksrdaarsrr gkenfefyel akllplpaai
      121 tsqldkasii rltisylkmr dfanqgdppw nlrmegpppn tsvkgiqmwk selcmrktpc
      181 evigaqrrrs psalaievfe ahlgshilqs ldgfvfalnq egkflyiset vsiylglsqv
      241 eltgssvfdy vhpgdhvema eqlgmklppg rgllsqgtae dgassassss qsetpepves
      301 tspsllttdn tlersffirm kstltkrgvh ikssgykvih itgrlrlrvs lshgrtvpsq
      361 imglvvvaha lppptinevr idchmfvtrv nmdlniiyce nrisdymdlt pvdivgkrcy
      421 hfihaedveg irhshldlln kgqcvtkyyr wmqknggyiw iqssatiain aknaneknii
      481 wvnyllsnpe ykdtpmdiaq lphlpektse ssetsdsesd skdtsgited nensksdekg
      541 nqsensedpe pdrkksgnac dndmncnddg hsssnpdsrd sddsfehsdf enpkagedgf
      601 galgamqikv eryvesesdl rlqnceslts dsakdsdsag eagaqasskh qkrkkrrkrq
      661 kggsasrrrl ssasspggld aglvepprll sspnsasvlk ikteisepin fdndssiwny
      721 ppnreisrne spysmtkpps sehfpspqgg gggggggggl hvaipdsvlt ppgadgaaar
      781 ktqfgasata alapvasdpl spplsasprd khpgnggggg gggggagggg psasnsllyt
      841 gdlealqrlq agnvvlplvh rvtgtlaats taaqrvyttg tiryapaevt lamqsnllpn
      901 ahavnfvdvn spgfgldpkt pmemlyhhvh rlnmsgpfgg avsaasltqm pagnvfttae
      961 glfstlpfpv ysngihaaqt lerked
//
LOCUS       XP_047287634             984 aa            linear   PRI 05-AUG-2025
DEFINITION  neuronal PAS domain-containing protein 3 isoform X2 [Homo sapiens].
ACCESSION   XP_047287634
VERSION     XP_047287634.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431678.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..984
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..984
                     /product="neuronal PAS domain-containing protein 3 isoform
                     X2"
                     /calculated_mol_wt=105586
     Region          84..160
                     /region_name="bHLH-PAS_NPAS3_PASD6"
                     /note="basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS)
                     domain found in neuronal PAS domain-containing protein 3
                     (NPAS3) and similar proteins; cd19732"
                     /db_xref="CDD:381575"
     Site            order(89,91..93,97,99..100,104,125..126)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381575"
     Site            order(99,102..103,106,109..110,113,115..116,127,130..132,
                     134,136..140)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:381575"
     Region          203..261
                     /region_name="PAS"
                     /note="PAS domain; smart00091"
                     /db_xref="CDD:214512"
     Region          205..>464
                     /region_name="KinE"
                     /note="Sporulation sensor histidine kinase E [Cell cycle
                     control, cell division, chromosome partitioning, Signal
                     transduction mechanisms]; COG5809"
                     /db_xref="CDD:444511"
     Region          394..481
                     /region_name="PAS_3"
                     /note="PAS fold; pfam08447"
                     /db_xref="CDD:430001"
     Site            order(397,401,407,420..423,449,454)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:238075"
     Site            order(417,421,429,432..433,461,463)
                     /site_type="other"
                     /note="heme pocket [chemical binding]"
                     /db_xref="CDD:238075"
     Region          <487..>646
                     /region_name="MSCRAMM_ClfA"
                     /note="MSCRAMM family adhesin clumping factor ClfA;
                     NF033609"
                     /db_xref="CDD:468110"
     CDS             1..984
                     /gene="NPAS3"
                     /gene_synonym="bHLHe12; MOP6; PASD6"
                     /coded_by="XM_047431678.1:62..3016"
                     /db_xref="GeneID:64067"
                     /db_xref="HGNC:HGNC:19311"
                     /db_xref="MIM:609430"
ORIGIN      
        1 mirifpdfsv qvtaaaagga aagvpagagm gragaaangt pqnvqgitsy qqritaqhpl
       61 pnqsecrkiy rydgiycest yqnlqalrke ksrdaarsrr gkenfefyel akllplpaai
      121 tsqldkasii rltisylkmr dfanqgdppw nlrmegpppn tsvkgiqmwk selcmrktpc
      181 egaqrrrsps alaievfeah lgshilqsld gfvfalnqeg kflyisetvs iylglsqvel
      241 tgssvfdyvh pgdhvemaeq lgmklppgrg llsqgtaedg assassssqs etpepvests
      301 psllttdntl ersffirmks tltkrgvhik ssgykvihit grlrlrvsls hgrtvpsqim
      361 glvvvahalp pptinevrid chmfvtrvnm dlniiycenr isdymdltpv divgkrcyhf
      421 ihaedvegir hshldllnkg qcvtkyyrwm qknggyiwiq ssatiainak nanekniiwv
      481 nyllsnpeyk dtpmdiaqlp hlpektsess etsdsesdsk dtsgitedne nsksdekgnq
      541 sensedpepd rkksgnacdn dmncnddghs ssnpdsrdsd dsfehsdfen pkagedgfga
      601 lgamqikver yvesesdlrl qncesltsds akdsdsagea gaqasskhqk rkkrrkrqkg
      661 gsasrrrlss asspggldag lvepprllss pnsasvlkik teisepinfd ndssiwnypp
      721 nreisrnesp ysmtkppsse hfpspqgggg ggggggglhv aipdsvltpp gadgaaarkt
      781 qfgasataal apvasdplsp plsasprdkh pgnggggggg gggaggggps asnsllytgd
      841 lealqrlqag nvvlplvhrv tgtlaatsta aqrvyttgti ryapaevtla mqsnllpnah
      901 avnfvdvnsp gfgldpktpm emlyhhvhrl nmsgpfggav saasltqmpa gnvfttaegl
      961 fstlpfpvys ngihaaqtle rked
//
LOCUS       XP_016877072             983 aa            linear   PRI 05-AUG-2025
DEFINITION  neuronal PAS domain-containing protein 3 isoform X3 [Homo sapiens].
ACCESSION   XP_016877072
VERSION     XP_016877072.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021583.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..983
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..983
                     /product="neuronal PAS domain-containing protein 3 isoform
                     X3"
                     /calculated_mol_wt=105527
     Region          84..160
                     /region_name="bHLH-PAS_NPAS3_PASD6"
                     /note="basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS)
                     domain found in neuronal PAS domain-containing protein 3
                     (NPAS3) and similar proteins; cd19732"
                     /db_xref="CDD:381575"
     Site            order(89,91..93,97,99..100,104,125..126)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381575"
     Site            order(99,102..103,106,109..110,113,115..116,127,130..132,
                     134,136..140)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:381575"
     Region          205..263
                     /region_name="PAS"
                     /note="PAS domain; smart00091"
                     /db_xref="CDD:214512"
     Region          207..>466
                     /region_name="KinE"
                     /note="Sporulation sensor histidine kinase E [Cell cycle
                     control, cell division, chromosome partitioning, Signal
                     transduction mechanisms]; COG5809"
                     /db_xref="CDD:444511"
     Region          396..483
                     /region_name="PAS_3"
                     /note="PAS fold; pfam08447"
                     /db_xref="CDD:430001"
     Site            order(399,403,409,422..425,451,456)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:238075"
     Site            order(419,423,431,434..435,463,465)
                     /site_type="other"
                     /note="heme pocket [chemical binding]"
                     /db_xref="CDD:238075"
     Region          <525..645
                     /region_name="MSCRAMM_ClfA"
                     /note="MSCRAMM family adhesin clumping factor ClfA;
                     NF033609"
                     /db_xref="CDD:468110"
     CDS             1..983
                     /gene="NPAS3"
                     /gene_synonym="bHLHe12; MOP6; PASD6"
                     /coded_by="XM_017021583.2:62..3013"
                     /db_xref="GeneID:64067"
                     /db_xref="HGNC:HGNC:19311"
                     /db_xref="MIM:609430"
ORIGIN      
        1 mirifpdfsv qvtaaaagga aagvpagagm gragaaangt pqnvqgitsy qqritaqhpl
       61 pnqsecrkiy rydgiycest yqnlqalrke ksrdaarsrr gkenfefyel akllplpaai
      121 tsqldkasii rltisylkmr dfanqgdppw nlrmegpppn tsvkgiqmwk selcmrktpc
      181 evigaqrrrs psalaievfe ahlgshilqs ldgfvfalnq egkflyiset vsiylglsqv
      241 eltgssvfdy vhpgdhvema eqlgmklppg rgllsqgtae dgassassss qsetpepves
      301 tspsllttdn tlersffirm kstltkrgvh ikssgykvih itgrlrlrvs lshgrtvpsq
      361 imglvvvaha lppptinevr idchmfvtrv nmdlniiyce nrisdymdlt pvdivgkrcy
      421 hfihaedveg irhshldlln kgqcvtkyyr wmqknggyiw iqssatiain aknaneknii
      481 wvnyllsnpe ykdtpmdiaq lphlpektse ssetsdsesd skdtsednen sksdekgnqs
      541 ensedpepdr kksgnacdnd mncnddghss snpdsrdsdd sfehsdfenp kagedgfgal
      601 gamqikvery vesesdlrlq ncesltsdsa kdsdsageag aqasskhqkr kkrrkrqkgg
      661 sasrrrlssa sspggldagl vepprllssp nsasvlkikt eisepinfdn dssiwnyppn
      721 reisrnespy smtkppsseh fpspqggggg gggggglhva ipdsvltppg adgaaarktq
      781 fgasataala pvasdplspp lsasprdkhp gngggggggg ggaggggpsa snsllytgdl
      841 ealqrlqagn vvlplvhrvt gtlaatstaa qrvyttgtir yapaevtlam qsnllpnaha
      901 vnfvdvnspg fgldpktpme mlyhhvhrln msgpfggavs aasltqmpag nvfttaeglf
      961 stlpfpvysn gihaaqtler ked
//
LOCUS       XP_005268048             969 aa            linear   PRI 05-AUG-2025
DEFINITION  neuronal PAS domain-containing protein 3 isoform X4 [Homo sapiens].
ACCESSION   XP_005268048
VERSION     XP_005268048.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267991.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Jun 6, 2016 this sequence version replaced XP_005268048.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..969
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..969
                     /product="neuronal PAS domain-containing protein 3 isoform
                     X4"
                     /calculated_mol_wt=103776
     Region          84..160
                     /region_name="bHLH-PAS_NPAS3_PASD6"
                     /note="basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS)
                     domain found in neuronal PAS domain-containing protein 3
                     (NPAS3) and similar proteins; cd19732"
                     /db_xref="CDD:381575"
     Site            order(89,91..93,97,99..100,104,125..126)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381575"
     Site            order(99,102..103,106,109..110,113,115..116,127,130..132,
                     134,136..140)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:381575"
     Region          188..246
                     /region_name="PAS"
                     /note="PAS domain; smart00091"
                     /db_xref="CDD:214512"
     Region          190..>449
                     /region_name="KinE"
                     /note="Sporulation sensor histidine kinase E [Cell cycle
                     control, cell division, chromosome partitioning, Signal
                     transduction mechanisms]; COG5809"
                     /db_xref="CDD:444511"
     Region          379..466
                     /region_name="PAS_3"
                     /note="PAS fold; pfam08447"
                     /db_xref="CDD:430001"
     Site            order(382,386,392,405..408,434,439)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:238075"
     Site            order(402,406,414,417..418,446,448)
                     /site_type="other"
                     /note="heme pocket [chemical binding]"
                     /db_xref="CDD:238075"
     Region          <472..>631
                     /region_name="MSCRAMM_ClfA"
                     /note="MSCRAMM family adhesin clumping factor ClfA;
                     NF033609"
                     /db_xref="CDD:468110"
     CDS             1..969
                     /gene="NPAS3"
                     /gene_synonym="bHLHe12; MOP6; PASD6"
                     /coded_by="XM_005267991.4:62..2971"
                     /db_xref="GeneID:64067"
                     /db_xref="HGNC:HGNC:19311"
                     /db_xref="MIM:609430"
ORIGIN      
        1 mirifpdfsv qvtaaaagga aagvpagagm gragaaangt pqnvqgitsy qqritaqhpl
       61 pnqsecrkiy rydgiycest yqnlqalrke ksrdaarsrr gkenfefyel akllplpaai
      121 tsqldkasii rltisylkmr dfanqgdppw nlrmegpppn tsvkvigaqr rrspsalaie
      181 vfeahlgshi lqsldgfvfa lnqegkflyi setvsiylgl sqveltgssv fdyvhpgdhv
      241 emaeqlgmkl ppgrgllsqg taedgassas sssqsetpep vestspsllt tdntlersff
      301 irmkstltkr gvhikssgyk vihitgrlrl rvslshgrtv psqimglvvv ahalppptin
      361 evridchmfv trvnmdlnii ycenrisdym dltpvdivgk rcyhfihaed vegirhshld
      421 llnkgqcvtk yyrwmqkngg yiwiqssati ainaknanek niiwvnylls npeykdtpmd
      481 iaqlphlpek tsessetsds esdskdtsgi tednensksd ekgnqsense dpepdrkksg
      541 nacdndmncn ddghsssnpd srdsddsfeh sdfenpkage dgfgalgamq ikveryvese
      601 sdlrlqnces ltsdsakdsd sageagaqas skhqkrkkrr krqkggsasr rrlssasspg
      661 gldaglvepp rllsspnsas vlkikteise pinfdndssi wnyppnreis rnespysmtk
      721 ppssehfpsp qggggggggg gglhvaipds vltppgadga aarktqfgas ataalapvas
      781 dplspplsas prdkhpgngg ggggggggag gggpsasnsl lytgdlealq rlqagnvvlp
      841 lvhrvtgtla atstaaqrvy ttgtiryapa evtlamqsnl lpnahavnfv dvnspgfgld
      901 pktpmemlyh hvhrlnmsgp fggavsaasl tqmpagnvft taeglfstlp fpvysngiha
      961 aqtlerked
//
LOCUS       XP_005268049             967 aa            linear   PRI 05-AUG-2025
DEFINITION  neuronal PAS domain-containing protein 3 isoform X5 [Homo sapiens].
ACCESSION   XP_005268049
VERSION     XP_005268049.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267992.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Jun 6, 2016 this sequence version replaced XP_005268049.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..967
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..967
                     /product="neuronal PAS domain-containing protein 3 isoform
                     X5"
                     /calculated_mol_wt=103564
     Region          84..160
                     /region_name="bHLH-PAS_NPAS3_PASD6"
                     /note="basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS)
                     domain found in neuronal PAS domain-containing protein 3
                     (NPAS3) and similar proteins; cd19732"
                     /db_xref="CDD:381575"
     Site            order(89,91..93,97,99..100,104,125..126)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381575"
     Site            order(99,102..103,106,109..110,113,115..116,127,130..132,
                     134,136..140)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:381575"
     Region          186..244
                     /region_name="PAS"
                     /note="PAS domain; smart00091"
                     /db_xref="CDD:214512"
     Region          188..>447
                     /region_name="KinE"
                     /note="Sporulation sensor histidine kinase E [Cell cycle
                     control, cell division, chromosome partitioning, Signal
                     transduction mechanisms]; COG5809"
                     /db_xref="CDD:444511"
     Region          377..464
                     /region_name="PAS_3"
                     /note="PAS fold; pfam08447"
                     /db_xref="CDD:430001"
     Site            order(380,384,390,403..406,432,437)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:238075"
     Site            order(400,404,412,415..416,444,446)
                     /site_type="other"
                     /note="heme pocket [chemical binding]"
                     /db_xref="CDD:238075"
     Region          <470..>629
                     /region_name="MSCRAMM_ClfA"
                     /note="MSCRAMM family adhesin clumping factor ClfA;
                     NF033609"
                     /db_xref="CDD:468110"
     CDS             1..967
                     /gene="NPAS3"
                     /gene_synonym="bHLHe12; MOP6; PASD6"
                     /coded_by="XM_005267992.4:50..2953"
                     /db_xref="GeneID:64067"
                     /db_xref="HGNC:HGNC:19311"
                     /db_xref="MIM:609430"
ORIGIN      
        1 mirifpdfsv qvtaaaagga aagvpagagm gragaaangt pqnvqgitsy qqritaqhpl
       61 pnqsecrkiy rydgiycest yqnlqalrke ksrdaarsrr gkenfefyel akllplpaai
      121 tsqldkasii rltisylkmr dfanqgdppw nlrmegpppn tsvkgaqrrr spsalaievf
      181 eahlgshilq sldgfvfaln qegkflyise tvsiylglsq veltgssvfd yvhpgdhvem
      241 aeqlgmklpp grgllsqgta edgassasss sqsetpepve stspsllttd ntlersffir
      301 mkstltkrgv hikssgykvi hitgrlrlrv slshgrtvps qimglvvvah alppptinev
      361 ridchmfvtr vnmdlniiyc enrisdymdl tpvdivgkrc yhfihaedve girhshldll
      421 nkgqcvtkyy rwmqknggyi wiqssatiai naknanekni iwvnyllsnp eykdtpmdia
      481 qlphlpekts essetsdses dskdtsgite dnensksdek gnqsensedp epdrkksgna
      541 cdndmncndd ghsssnpdsr dsddsfehsd fenpkagedg fgalgamqik veryvesesd
      601 lrlqnceslt sdsakdsdsa geagaqassk hqkrkkrrkr qkggsasrrr lssasspggl
      661 daglvepprl lsspnsasvl kikteisepi nfdndssiwn yppnreisrn espysmtkpp
      721 ssehfpspqg gggggggggg lhvaipdsvl tppgadgaaa rktqfgasat aalapvasdp
      781 lspplsaspr dkhpgngggg ggggggaggg gpsasnslly tgdlealqrl qagnvvlplv
      841 hrvtgtlaat staaqrvytt gtiryapaev tlamqsnllp nahavnfvdv nspgfgldpk
      901 tpmemlyhhv hrlnmsgpfg gavsaasltq mpagnvftta eglfstlpfp vysngihaaq
      961 tlerked
//
LOCUS       XP_011535371             966 aa            linear   PRI 05-AUG-2025
DEFINITION  neuronal PAS domain-containing protein 3 isoform X6 [Homo sapiens].
ACCESSION   XP_011535371
VERSION     XP_011535371.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537069.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Jun 6, 2016 this sequence version replaced XP_011535371.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..966
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..966
                     /product="neuronal PAS domain-containing protein 3 isoform
                     X6"
                     /calculated_mol_wt=103505
     Region          84..160
                     /region_name="bHLH-PAS_NPAS3_PASD6"
                     /note="basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS)
                     domain found in neuronal PAS domain-containing protein 3
                     (NPAS3) and similar proteins; cd19732"
                     /db_xref="CDD:381575"
     Site            order(89,91..93,97,99..100,104,125..126)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381575"
     Site            order(99,102..103,106,109..110,113,115..116,127,130..132,
                     134,136..140)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:381575"
     Region          188..246
                     /region_name="PAS"
                     /note="PAS domain; smart00091"
                     /db_xref="CDD:214512"
     Region          190..>449
                     /region_name="KinE"
                     /note="Sporulation sensor histidine kinase E [Cell cycle
                     control, cell division, chromosome partitioning, Signal
                     transduction mechanisms]; COG5809"
                     /db_xref="CDD:444511"
     Region          379..466
                     /region_name="PAS_3"
                     /note="PAS fold; pfam08447"
                     /db_xref="CDD:430001"
     Site            order(382,386,392,405..408,434,439)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:238075"
     Site            order(402,406,414,417..418,446,448)
                     /site_type="other"
                     /note="heme pocket [chemical binding]"
                     /db_xref="CDD:238075"
     Region          <508..628
                     /region_name="MSCRAMM_ClfA"
                     /note="MSCRAMM family adhesin clumping factor ClfA;
                     NF033609"
                     /db_xref="CDD:468110"
     CDS             1..966
                     /gene="NPAS3"
                     /gene_synonym="bHLHe12; MOP6; PASD6"
                     /coded_by="XM_011537069.3:62..2962"
                     /db_xref="GeneID:64067"
                     /db_xref="HGNC:HGNC:19311"
                     /db_xref="MIM:609430"
ORIGIN      
        1 mirifpdfsv qvtaaaagga aagvpagagm gragaaangt pqnvqgitsy qqritaqhpl
       61 pnqsecrkiy rydgiycest yqnlqalrke ksrdaarsrr gkenfefyel akllplpaai
      121 tsqldkasii rltisylkmr dfanqgdppw nlrmegpppn tsvkvigaqr rrspsalaie
      181 vfeahlgshi lqsldgfvfa lnqegkflyi setvsiylgl sqveltgssv fdyvhpgdhv
      241 emaeqlgmkl ppgrgllsqg taedgassas sssqsetpep vestspsllt tdntlersff
      301 irmkstltkr gvhikssgyk vihitgrlrl rvslshgrtv psqimglvvv ahalppptin
      361 evridchmfv trvnmdlnii ycenrisdym dltpvdivgk rcyhfihaed vegirhshld
      421 llnkgqcvtk yyrwmqkngg yiwiqssati ainaknanek niiwvnylls npeykdtpmd
      481 iaqlphlpek tsessetsds esdskdtsed nensksdekg nqsensedpe pdrkksgnac
      541 dndmncnddg hsssnpdsrd sddsfehsdf enpkagedgf galgamqikv eryvesesdl
      601 rlqnceslts dsakdsdsag eagaqasskh qkrkkrrkrq kggsasrrrl ssasspggld
      661 aglvepprll sspnsasvlk ikteisepin fdndssiwny ppnreisrne spysmtkpps
      721 sehfpspqgg gggggggggl hvaipdsvlt ppgadgaaar ktqfgasata alapvasdpl
      781 spplsasprd khpgnggggg gggggagggg psasnsllyt gdlealqrlq agnvvlplvh
      841 rvtgtlaats taaqrvyttg tiryapaevt lamqsnllpn ahavnfvdvn spgfgldpkt
      901 pmemlyhhvh rlnmsgpfgg avsaasltqm pagnvfttae glfstlpfpv ysngihaaqt
      961 lerked
//
LOCUS       XP_016877073             956 aa            linear   PRI 05-AUG-2025
DEFINITION  neuronal PAS domain-containing protein 3 isoform X7 [Homo sapiens].
ACCESSION   XP_016877073
VERSION     XP_016877073.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021584.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..956
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..956
                     /product="neuronal PAS domain-containing protein 3 isoform
                     X7"
                     /calculated_mol_wt=102225
     Region          53..130
                     /region_name="bHLH-PAS_NPAS3_PASD6"
                     /note="basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS)
                     domain found in neuronal PAS domain-containing protein 3
                     (NPAS3) and similar proteins; cd19732"
                     /db_xref="CDD:381575"
     Site            order(59,61..63,67,69..70,74,95..96)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381575"
     Site            order(69,72..73,76,79..80,83,85..86,97,100..102,104,
                     106..110)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:381575"
     Region          175..233
                     /region_name="PAS"
                     /note="PAS domain; smart00091"
                     /db_xref="CDD:214512"
     Region          177..>436
                     /region_name="KinE"
                     /note="Sporulation sensor histidine kinase E [Cell cycle
                     control, cell division, chromosome partitioning, Signal
                     transduction mechanisms]; COG5809"
                     /db_xref="CDD:444511"
     Region          366..453
                     /region_name="PAS_3"
                     /note="PAS fold; pfam08447"
                     /db_xref="CDD:430001"
     Site            order(369,373,379,392..395,421,426)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:238075"
     Site            order(389,393,401,404..405,433,435)
                     /site_type="other"
                     /note="heme pocket [chemical binding]"
                     /db_xref="CDD:238075"
     Region          <459..>618
                     /region_name="MSCRAMM_ClfA"
                     /note="MSCRAMM family adhesin clumping factor ClfA;
                     NF033609"
                     /db_xref="CDD:468110"
     CDS             1..956
                     /gene="NPAS3"
                     /gene_synonym="bHLHe12; MOP6; PASD6"
                     /coded_by="XM_017021584.2:62..2932"
                     /db_xref="GeneID:64067"
                     /db_xref="HGNC:HGNC:19311"
                     /db_xref="MIM:609430"
ORIGIN      
        1 mirifpdfsv qvtaaaagga aagvpagagm gragaaangt pqnvqgitsy qqrlqalrke
       61 ksrdaarsrr gkenfefyel akllplpaai tsqldkasii rltisylkmr dfanqgdppw
      121 nlrmegpppn tsvkgiqmwk selcmrktpc evigaqrrrs psalaievfe ahlgshilqs
      181 ldgfvfalnq egkflyiset vsiylglsqv eltgssvfdy vhpgdhvema eqlgmklppg
      241 rgllsqgtae dgassassss qsetpepves tspsllttdn tlersffirm kstltkrgvh
      301 ikssgykvih itgrlrlrvs lshgrtvpsq imglvvvaha lppptinevr idchmfvtrv
      361 nmdlniiyce nrisdymdlt pvdivgkrcy hfihaedveg irhshldlln kgqcvtkyyr
      421 wmqknggyiw iqssatiain aknaneknii wvnyllsnpe ykdtpmdiaq lphlpektse
      481 ssetsdsesd skdtsgited nensksdekg nqsensedpe pdrkksgnac dndmncnddg
      541 hsssnpdsrd sddsfehsdf enpkagedgf galgamqikv eryvesesdl rlqnceslts
      601 dsakdsdsag eagaqasskh qkrkkrrkrq kggsasrrrl ssasspggld aglvepprll
      661 sspnsasvlk ikteisepin fdndssiwny ppnreisrne spysmtkpps sehfpspqgg
      721 gggggggggl hvaipdsvlt ppgadgaaar ktqfgasata alapvasdpl spplsasprd
      781 khpgnggggg gggggagggg psasnsllyt gdlealqrlq agnvvlplvh rvtgtlaats
      841 taaqrvyttg tiryapaevt lamqsnllpn ahavnfvdvn spgfgldpkt pmemlyhhvh
      901 rlnmsgpfgg avsaasltqm pagnvfttae glfstlpfpv ysngihaaqt lerked
//
LOCUS       XP_011535369             950 aa            linear   PRI 05-AUG-2025
DEFINITION  neuronal PAS domain-containing protein 3 isoform X8 [Homo sapiens].
ACCESSION   XP_011535369
VERSION     XP_011535369.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537067.3
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 10% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..950
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..950
                     /product="neuronal PAS domain-containing protein 3 isoform
                     X8"
                     /calculated_mol_wt=102697
     Region          48..124
                     /region_name="bHLH-PAS_NPAS3_PASD6"
                     /note="basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS)
                     domain found in neuronal PAS domain-containing protein 3
                     (NPAS3) and similar proteins; cd19732"
                     /db_xref="CDD:381575"
     Site            order(53,55..57,61,63..64,68,89..90)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381575"
     Site            order(63,66..67,70,73..74,77,79..80,91,94..96,98,100..104)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:381575"
     Region          169..227
                     /region_name="PAS"
                     /note="PAS domain; smart00091"
                     /db_xref="CDD:214512"
     Region          171..>430
                     /region_name="KinE"
                     /note="Sporulation sensor histidine kinase E [Cell cycle
                     control, cell division, chromosome partitioning, Signal
                     transduction mechanisms]; COG5809"
                     /db_xref="CDD:444511"
     Region          360..447
                     /region_name="PAS_3"
                     /note="PAS fold; pfam08447"
                     /db_xref="CDD:430001"
     Site            order(363,367,373,386..389,415,420)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:238075"
     Site            order(383,387,395,398..399,427,429)
                     /site_type="other"
                     /note="heme pocket [chemical binding]"
                     /db_xref="CDD:238075"
     Region          <453..>612
                     /region_name="MSCRAMM_ClfA"
                     /note="MSCRAMM family adhesin clumping factor ClfA;
                     NF033609"
                     /db_xref="CDD:468110"
     CDS             1..950
                     /gene="NPAS3"
                     /gene_synonym="bHLHe12; MOP6; PASD6"
                     /coded_by="XM_011537067.3:439..3291"
                     /db_xref="GeneID:64067"
                     /db_xref="HGNC:HGNC:19311"
                     /db_xref="MIM:609430"
ORIGIN      
        1 maptkpsfqq dpsrrerita qhplpnqsec rkiyrydgiy cestyqnlqa lrkeksrdaa
       61 rsrrgkenfe fyelakllpl paaitsqldk asiirltisy lkmrdfanqg dppwnlrmeg
      121 pppntsvkgi qmwkselcmr ktpcevigaq rrrspsalai evfeahlgsh ilqsldgfvf
      181 alnqegkfly isetvsiylg lsqveltgss vfdyvhpgdh vemaeqlgmk lppgrgllsq
      241 gtaedgassa ssssqsetpe pvestspsll ttdntlersf firmkstltk rgvhikssgy
      301 kvihitgrlr lrvslshgrt vpsqimglvv vahalpppti nevridchmf vtrvnmdlni
      361 iycenrisdy mdltpvdivg krcyhfihae dvegirhshl dllnkgqcvt kyyrwmqkng
      421 gyiwiqssat iainaknane kniiwvnyll snpeykdtpm diaqlphlpe ktsessetsd
      481 sesdskdtsg itednensks dekgnqsens edpepdrkks gnacdndmnc nddghsssnp
      541 dsrdsddsfe hsdfenpkag edgfgalgam qikveryves esdlrlqnce sltsdsakds
      601 dsageagaqa sskhqkrkkr rkrqkggsas rrrlssassp ggldaglvep prllsspnsa
      661 svlkikteis epinfdndss iwnyppnrei srnespysmt kppssehfps pqgggggggg
      721 ggglhvaipd svltppgadg aaarktqfga sataalapva sdplspplsa sprdkhpgng
      781 ggggggggga ggggpsasns llytgdleal qrlqagnvvl plvhrvtgtl aatstaaqrv
      841 yttgtiryap aevtlamqsn llpnahavnf vdvnspgfgl dpktpmemly hhvhrlnmsg
      901 pfggavsaas ltqmpagnvf ttaeglfstl pfpvysngih aaqtlerked
//
LOCUS       XP_016877074             939 aa            linear   PRI 05-AUG-2025
DEFINITION  neuronal PAS domain-containing protein 3 isoform X9 [Homo sapiens].
ACCESSION   XP_016877074
VERSION     XP_016877074.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021585.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..939
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..939
                     /product="neuronal PAS domain-containing protein 3 isoform
                     X9"
                     /calculated_mol_wt=100202
     Region          53..130
                     /region_name="bHLH-PAS_NPAS3_PASD6"
                     /note="basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS)
                     domain found in neuronal PAS domain-containing protein 3
                     (NPAS3) and similar proteins; cd19732"
                     /db_xref="CDD:381575"
     Site            order(59,61..63,67,69..70,74,95..96)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381575"
     Site            order(69,72..73,76,79..80,83,85..86,97,100..102,104,
                     106..110)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:381575"
     Region          158..216
                     /region_name="PAS"
                     /note="PAS domain; smart00091"
                     /db_xref="CDD:214512"
     Region          160..>419
                     /region_name="KinE"
                     /note="Sporulation sensor histidine kinase E [Cell cycle
                     control, cell division, chromosome partitioning, Signal
                     transduction mechanisms]; COG5809"
                     /db_xref="CDD:444511"
     Region          349..436
                     /region_name="PAS_3"
                     /note="PAS fold; pfam08447"
                     /db_xref="CDD:430001"
     Site            order(352,356,362,375..378,404,409)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:238075"
     Site            order(372,376,384,387..388,416,418)
                     /site_type="other"
                     /note="heme pocket [chemical binding]"
                     /db_xref="CDD:238075"
     Region          <442..>601
                     /region_name="MSCRAMM_ClfA"
                     /note="MSCRAMM family adhesin clumping factor ClfA;
                     NF033609"
                     /db_xref="CDD:468110"
     CDS             1..939
                     /gene="NPAS3"
                     /gene_synonym="bHLHe12; MOP6; PASD6"
                     /coded_by="XM_017021585.2:62..2881"
                     /db_xref="GeneID:64067"
                     /db_xref="HGNC:HGNC:19311"
                     /db_xref="MIM:609430"
ORIGIN      
        1 mirifpdfsv qvtaaaagga aagvpagagm gragaaangt pqnvqgitsy qqrlqalrke
       61 ksrdaarsrr gkenfefyel akllplpaai tsqldkasii rltisylkmr dfanqgdppw
      121 nlrmegpppn tsvkvigaqr rrspsalaie vfeahlgshi lqsldgfvfa lnqegkflyi
      181 setvsiylgl sqveltgssv fdyvhpgdhv emaeqlgmkl ppgrgllsqg taedgassas
      241 sssqsetpep vestspsllt tdntlersff irmkstltkr gvhikssgyk vihitgrlrl
      301 rvslshgrtv psqimglvvv ahalppptin evridchmfv trvnmdlnii ycenrisdym
      361 dltpvdivgk rcyhfihaed vegirhshld llnkgqcvtk yyrwmqkngg yiwiqssati
      421 ainaknanek niiwvnylls npeykdtpmd iaqlphlpek tsessetsds esdskdtsgi
      481 tednensksd ekgnqsense dpepdrkksg nacdndmncn ddghsssnpd srdsddsfeh
      541 sdfenpkage dgfgalgamq ikveryvese sdlrlqnces ltsdsakdsd sageagaqas
      601 skhqkrkkrr krqkggsasr rrlssasspg gldaglvepp rllsspnsas vlkikteise
      661 pinfdndssi wnyppnreis rnespysmtk ppssehfpsp qggggggggg gglhvaipds
      721 vltppgadga aarktqfgas ataalapvas dplspplsas prdkhpgngg ggggggggag
      781 gggpsasnsl lytgdlealq rlqagnvvlp lvhrvtgtla atstaaqrvy ttgtiryapa
      841 evtlamqsnl lpnahavnfv dvnspgfgld pktpmemlyh hvhrlnmsgp fggavsaasl
      901 tqmpagnvft taeglfstlp fpvysngiha aqtlerked
//
LOCUS       XP_011535373             936 aa            linear   PRI 05-AUG-2025
DEFINITION  neuronal PAS domain-containing protein 3 isoform X10 [Homo
            sapiens].
ACCESSION   XP_011535373
VERSION     XP_011535373.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537071.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Jun 6, 2016 this sequence version replaced XP_011535373.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..936
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..936
                     /product="neuronal PAS domain-containing protein 3 isoform
                     X10"
                     /calculated_mol_wt=99931
     Region          53..130
                     /region_name="bHLH-PAS_NPAS3_PASD6"
                     /note="basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS)
                     domain found in neuronal PAS domain-containing protein 3
                     (NPAS3) and similar proteins; cd19732"
                     /db_xref="CDD:381575"
     Site            order(59,61..63,67,69..70,74,95..96)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381575"
     Site            order(69,72..73,76,79..80,83,85..86,97,100..102,104,
                     106..110)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:381575"
     Region          158..216
                     /region_name="PAS"
                     /note="PAS domain; smart00091"
                     /db_xref="CDD:214512"
     Region          160..>419
                     /region_name="KinE"
                     /note="Sporulation sensor histidine kinase E [Cell cycle
                     control, cell division, chromosome partitioning, Signal
                     transduction mechanisms]; COG5809"
                     /db_xref="CDD:444511"
     Region          349..436
                     /region_name="PAS_3"
                     /note="PAS fold; pfam08447"
                     /db_xref="CDD:430001"
     Site            order(352,356,362,375..378,404,409)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:238075"
     Site            order(372,376,384,387..388,416,418)
                     /site_type="other"
                     /note="heme pocket [chemical binding]"
                     /db_xref="CDD:238075"
     Region          <478..598
                     /region_name="MSCRAMM_ClfA"
                     /note="MSCRAMM family adhesin clumping factor ClfA;
                     NF033609"
                     /db_xref="CDD:468110"
     CDS             1..936
                     /gene="NPAS3"
                     /gene_synonym="bHLHe12; MOP6; PASD6"
                     /coded_by="XM_011537071.3:47..2857"
                     /db_xref="GeneID:64067"
                     /db_xref="HGNC:HGNC:19311"
                     /db_xref="MIM:609430"
ORIGIN      
        1 mirifpdfsv qvtaaaagga aagvpagagm gragaaangt pqnvqgitsy qqrlqalrke
       61 ksrdaarsrr gkenfefyel akllplpaai tsqldkasii rltisylkmr dfanqgdppw
      121 nlrmegpppn tsvkvigaqr rrspsalaie vfeahlgshi lqsldgfvfa lnqegkflyi
      181 setvsiylgl sqveltgssv fdyvhpgdhv emaeqlgmkl ppgrgllsqg taedgassas
      241 sssqsetpep vestspsllt tdntlersff irmkstltkr gvhikssgyk vihitgrlrl
      301 rvslshgrtv psqimglvvv ahalppptin evridchmfv trvnmdlnii ycenrisdym
      361 dltpvdivgk rcyhfihaed vegirhshld llnkgqcvtk yyrwmqkngg yiwiqssati
      421 ainaknanek niiwvnylls npeykdtpmd iaqlphlpek tsessetsds esdskdtsed
      481 nensksdekg nqsensedpe pdrkksgnac dndmncnddg hsssnpdsrd sddsfehsdf
      541 enpkagedgf galgamqikv eryvesesdl rlqnceslts dsakdsdsag eagaqasskh
      601 qkrkkrrkrq kggsasrrrl ssasspggld aglvepprll sspnsasvlk ikteisepin
      661 fdndssiwny ppnreisrne spysmtkpps sehfpspqgg gggggggggl hvaipdsvlt
      721 ppgadgaaar ktqfgasata alapvasdpl spplsasprd khpgnggggg gggggagggg
      781 psasnsllyt gdlealqrlq agnvvlplvh rvtgtlaats taaqrvyttg tiryapaevt
      841 lamqsnllpn ahavnfvdvn spgfgldpkt pmemlyhhvh rlnmsgpfgg avsaasltqm
      901 pagnvfttae glfstlpfpv ysngihaaqt lerked
//
LOCUS       XP_047287636             930 aa            linear   PRI 05-AUG-2025
DEFINITION  neuronal PAS domain-containing protein 3 isoform X11 [Homo
            sapiens].
ACCESSION   XP_047287636
VERSION     XP_047287636.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431680.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 10% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..930
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..930
                     /product="neuronal PAS domain-containing protein 3 isoform
                     X11"
                     /calculated_mol_wt=100403
     Region          48..124
                     /region_name="bHLH-PAS_NPAS3_PASD6"
                     /note="basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS)
                     domain found in neuronal PAS domain-containing protein 3
                     (NPAS3) and similar proteins; cd19732"
                     /db_xref="CDD:381575"
     Site            order(53,55..57,61,63..64,68,89..90)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381575"
     Site            order(63,66..67,70,73..74,77,79..80,91,94..96,98,100..104)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:381575"
     Region          152..210
                     /region_name="PAS"
                     /note="PAS domain; smart00091"
                     /db_xref="CDD:214512"
     Region          154..>413
                     /region_name="KinE"
                     /note="Sporulation sensor histidine kinase E [Cell cycle
                     control, cell division, chromosome partitioning, Signal
                     transduction mechanisms]; COG5809"
                     /db_xref="CDD:444511"
     Region          343..430
                     /region_name="PAS_3"
                     /note="PAS fold; pfam08447"
                     /db_xref="CDD:430001"
     Site            order(346,350,356,369..372,398,403)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:238075"
     Site            order(366,370,378,381..382,410,412)
                     /site_type="other"
                     /note="heme pocket [chemical binding]"
                     /db_xref="CDD:238075"
     Region          <472..592
                     /region_name="MSCRAMM_ClfA"
                     /note="MSCRAMM family adhesin clumping factor ClfA;
                     NF033609"
                     /db_xref="CDD:468110"
     CDS             1..930
                     /gene="NPAS3"
                     /gene_synonym="bHLHe12; MOP6; PASD6"
                     /coded_by="XM_047431680.1:439..3231"
                     /db_xref="GeneID:64067"
                     /db_xref="HGNC:HGNC:19311"
                     /db_xref="MIM:609430"
ORIGIN      
        1 maptkpsfqq dpsrrerita qhplpnqsec rkiyrydgiy cestyqnlqa lrkeksrdaa
       61 rsrrgkenfe fyelakllpl paaitsqldk asiirltisy lkmrdfanqg dppwnlrmeg
      121 pppntsvkvi gaqrrrspsa laievfeahl gshilqsldg fvfalnqegk flyisetvsi
      181 ylglsqvelt gssvfdyvhp gdhvemaeql gmklppgrgl lsqgtaedga ssassssqse
      241 tpepvestsp sllttdntle rsffirmkst ltkrgvhiks sgykvihitg rlrlrvslsh
      301 grtvpsqimg lvvvahalpp ptinevridc hmfvtrvnmd lniiycenri sdymdltpvd
      361 ivgkrcyhfi haedvegirh shldllnkgq cvtkyyrwmq knggyiwiqs satiainakn
      421 anekniiwvn yllsnpeykd tpmdiaqlph lpektsesse tsdsesdskd tsednensks
      481 dekgnqsens edpepdrkks gnacdndmnc nddghsssnp dsrdsddsfe hsdfenpkag
      541 edgfgalgam qikveryves esdlrlqnce sltsdsakds dsageagaqa sskhqkrkkr
      601 rkrqkggsas rrrlssassp ggldaglvep prllsspnsa svlkikteis epinfdndss
      661 iwnyppnrei srnespysmt kppssehfps pqgggggggg ggglhvaipd svltppgadg
      721 aaarktqfga sataalapva sdplspplsa sprdkhpgng ggggggggga ggggpsasns
      781 llytgdleal qrlqagnvvl plvhrvtgtl aatstaaqrv yttgtiryap aevtlamqsn
      841 llpnahavnf vdvnspgfgl dpktpmemly hhvhrlnmsg pfggavsaas ltqmpagnvf
      901 ttaeglfstl pfpvysngih aaqtlerked
//
LOCUS       XP_016877076             831 aa            linear   PRI 05-AUG-2025
DEFINITION  neuronal PAS domain-containing protein 3 isoform X12 [Homo
            sapiens].
ACCESSION   XP_016877076
VERSION     XP_016877076.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021587.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..831
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..831
                     /product="neuronal PAS domain-containing protein 3 isoform
                     X12"
                     /calculated_mol_wt=88786
     Region          <1..22
                     /region_name="bHLH_SF"
                     /note="basic Helix Loop Helix (bHLH) domain superfamily;
                     cl00081"
                     /db_xref="CDD:469605"
     Region          50..108
                     /region_name="PAS"
                     /note="PAS domain; smart00091"
                     /db_xref="CDD:214512"
     Region          52..>311
                     /region_name="KinE"
                     /note="Sporulation sensor histidine kinase E [Cell cycle
                     control, cell division, chromosome partitioning, Signal
                     transduction mechanisms]; COG5809"
                     /db_xref="CDD:444511"
     Region          241..328
                     /region_name="PAS_3"
                     /note="PAS fold; pfam08447"
                     /db_xref="CDD:430001"
     Site            order(244,248,254,267..270,296,301)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:238075"
     Site            order(264,268,276,279..280,308,310)
                     /site_type="other"
                     /note="heme pocket [chemical binding]"
                     /db_xref="CDD:238075"
     Region          <334..>493
                     /region_name="MSCRAMM_ClfA"
                     /note="MSCRAMM family adhesin clumping factor ClfA;
                     NF033609"
                     /db_xref="CDD:468110"
     CDS             1..831
                     /gene="NPAS3"
                     /gene_synonym="bHLHe12; MOP6; PASD6"
                     /coded_by="XM_017021587.2:2525..5020"
                     /db_xref="GeneID:64067"
                     /db_xref="HGNC:HGNC:19311"
                     /db_xref="MIM:609430"
ORIGIN      
        1 mrdfanqgdp pwnlrmegpp pntsvkviga qrrrspsala ievfeahlgs hilqsldgfv
       61 falnqegkfl yisetvsiyl glsqveltgs svfdyvhpgd hvemaeqlgm klppgrglls
      121 qgtaedgass assssqsetp epvestspsl lttdntlers ffirmkstlt krgvhikssg
      181 ykvihitgrl rlrvslshgr tvpsqimglv vvahalpppt inevridchm fvtrvnmdln
      241 iiycenrisd ymdltpvdiv gkrcyhfiha edvegirhsh ldllnkgqcv tkyyrwmqkn
      301 ggyiwiqssa tiainaknan ekniiwvnyl lsnpeykdtp mdiaqlphlp ektsessets
      361 dsesdskdts gitednensk sdekgnqsen sedpepdrkk sgnacdndmn cnddghsssn
      421 pdsrdsddsf ehsdfenpka gedgfgalga mqikveryve sesdlrlqnc esltsdsakd
      481 sdsageagaq asskhqkrkk rrkrqkggsa srrrlssass pggldaglve pprllsspns
      541 asvlkiktei sepinfdnds siwnyppnre isrnespysm tkppssehfp spqggggggg
      601 gggglhvaip dsvltppgad gaaarktqfg asataalapv asdplsppls asprdkhpgn
      661 gggggggggg aggggpsasn sllytgdlea lqrlqagnvv lplvhrvtgt laatstaaqr
      721 vyttgtirya paevtlamqs nllpnahavn fvdvnspgfg ldpktpmeml yhhvhrlnms
      781 gpfggavsaa sltqmpagnv fttaeglfst lpfpvysngi haaqtlerke d
//
LOCUS       XP_016877077             831 aa            linear   PRI 05-AUG-2025
DEFINITION  neuronal PAS domain-containing protein 3 isoform X12 [Homo
            sapiens].
ACCESSION   XP_016877077
VERSION     XP_016877077.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021588.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..831
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..831
                     /product="neuronal PAS domain-containing protein 3 isoform
                     X12"
                     /calculated_mol_wt=88786
     Region          <1..22
                     /region_name="bHLH_SF"
                     /note="basic Helix Loop Helix (bHLH) domain superfamily;
                     cl00081"
                     /db_xref="CDD:469605"
     Region          50..108
                     /region_name="PAS"
                     /note="PAS domain; smart00091"
                     /db_xref="CDD:214512"
     Region          52..>311
                     /region_name="KinE"
                     /note="Sporulation sensor histidine kinase E [Cell cycle
                     control, cell division, chromosome partitioning, Signal
                     transduction mechanisms]; COG5809"
                     /db_xref="CDD:444511"
     Region          241..328
                     /region_name="PAS_3"
                     /note="PAS fold; pfam08447"
                     /db_xref="CDD:430001"
     Site            order(244,248,254,267..270,296,301)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:238075"
     Site            order(264,268,276,279..280,308,310)
                     /site_type="other"
                     /note="heme pocket [chemical binding]"
                     /db_xref="CDD:238075"
     Region          <334..>493
                     /region_name="MSCRAMM_ClfA"
                     /note="MSCRAMM family adhesin clumping factor ClfA;
                     NF033609"
                     /db_xref="CDD:468110"
     CDS             1..831
                     /gene="NPAS3"
                     /gene_synonym="bHLHe12; MOP6; PASD6"
                     /coded_by="XM_017021588.2:473..2968"
                     /db_xref="GeneID:64067"
                     /db_xref="HGNC:HGNC:19311"
                     /db_xref="MIM:609430"
ORIGIN      
        1 mrdfanqgdp pwnlrmegpp pntsvkviga qrrrspsala ievfeahlgs hilqsldgfv
       61 falnqegkfl yisetvsiyl glsqveltgs svfdyvhpgd hvemaeqlgm klppgrglls
      121 qgtaedgass assssqsetp epvestspsl lttdntlers ffirmkstlt krgvhikssg
      181 ykvihitgrl rlrvslshgr tvpsqimglv vvahalpppt inevridchm fvtrvnmdln
      241 iiycenrisd ymdltpvdiv gkrcyhfiha edvegirhsh ldllnkgqcv tkyyrwmqkn
      301 ggyiwiqssa tiainaknan ekniiwvnyl lsnpeykdtp mdiaqlphlp ektsessets
      361 dsesdskdts gitednensk sdekgnqsen sedpepdrkk sgnacdndmn cnddghsssn
      421 pdsrdsddsf ehsdfenpka gedgfgalga mqikveryve sesdlrlqnc esltsdsakd
      481 sdsageagaq asskhqkrkk rrkrqkggsa srrrlssass pggldaglve pprllsspns
      541 asvlkiktei sepinfdnds siwnyppnre isrnespysm tkppssehfp spqggggggg
      601 gggglhvaip dsvltppgad gaaarktqfg asataalapv asdplsppls asprdkhpgn
      661 gggggggggg aggggpsasn sllytgdlea lqrlqagnvv lplvhrvtgt laatstaaqr
      721 vyttgtirya paevtlamqs nllpnahavn fvdvnspgfg ldpktpmeml yhhvhrlnms
      781 gpfggavsaa sltqmpagnv fttaeglfst lpfpvysngi haaqtlerke d
//
LOCUS       XP_016877078             304 aa            linear   PRI 05-AUG-2025
DEFINITION  acyl-coenzyme A thioesterase 1 isoform X1 [Homo sapiens].
ACCESSION   XP_016877078
VERSION     XP_016877078.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021589.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..304
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..304
                     /product="acyl-coenzyme A thioesterase 1 isoform X1"
                     /calculated_mol_wt=33278
     Region          86..295
                     /region_name="BAAT_C"
                     /note="BAAT / Acyl-CoA thioester hydrolase C terminal;
                     pfam08840"
                     /db_xref="CDD:430252"
     CDS             1..304
                     /gene="ACOT1"
                     /gene_synonym="ACH2; CTE-1; LACH2"
                     /coded_by="XM_017021589.2:16..930"
                     /db_xref="GeneID:641371"
                     /db_xref="HGNC:HGNC:33128"
                     /db_xref="MIM:614313"
ORIGIN      
        1 mnkvtintcq kfldehrfsf lvgrylgvgl lghmcepgpf pgivdmfgtg gglleyrasl
       61 lagkgfavma layynyedlp ktmetlhley feeavnylls hpevkgpgvg llgiskggel
      121 clsmasflkg itaavvings vanvggtlry kgetlppvgv nrnrikvtkd gyadivdvln
      181 splegpdqks fipveraest flflvgqddh nwksefyane ackrlqahgr rkpqiicype
      241 tghyieppyf plcraslhal vgspiiwgge prahamaqvd awkqlqtffh khlgghegti
      301 pskv
//
LOCUS       XP_016877079             298 aa            linear   PRI 05-AUG-2025
DEFINITION  acyl-coenzyme A thioesterase 1 isoform X2 [Homo sapiens].
ACCESSION   XP_016877079
VERSION     XP_016877079.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021590.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..298
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..298
                     /product="acyl-coenzyme A thioesterase 1 isoform X2"
                     /calculated_mol_wt=32594
     Region          80..289
                     /region_name="BAAT_C"
                     /note="BAAT / Acyl-CoA thioester hydrolase C terminal;
                     pfam08840"
                     /db_xref="CDD:430252"
     CDS             1..298
                     /gene="ACOT1"
                     /gene_synonym="ACH2; CTE-1; LACH2"
                     /coded_by="XM_017021590.2:2543..3439"
                     /db_xref="GeneID:641371"
                     /db_xref="HGNC:HGNC:33128"
                     /db_xref="MIM:614313"
ORIGIN      
        1 mlrsgtqilv kndelvkvql fqelqvtgre pgpfpgivdm fgtggglley rasllagkgf
       61 avmalayyny edlpktmetl hleyfeeavn yllshpevkg pgvgllgisk ggelclsmas
      121 flkgitaavv ingsvanvgg tlrykgetlp pvgvnrnrik vtkdgyadiv dvlnsplegp
      181 dqksfipver aestflflvg qddhnwksef yaneackrlq ahgrrkpqii cypetghyie
      241 ppyfplcras lhalvgspii wggepraham aqvdawkqlq tffhkhlggh egtipskv
//
LOCUS       XP_005268056             271 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/arginine-rich splicing factor 5 isoform X1 [Homo sapiens].
ACCESSION   XP_005268056
VERSION     XP_005268056.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005267999.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..271
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..271
                     /product="serine/arginine-rich splicing factor 5 isoform
                     X1"
                     /calculated_mol_wt=31046
     Region          5..74
                     /region_name="RRM1_SRSF5"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     serine/arginine-rich splicing factor 5 (SRSF5); cd12595"
                     /db_xref="CDD:410008"
     Region          99..179
                     /region_name="RRM2_SRSF5"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     serine/arginine-rich splicing factor 5 (SRSF5); cd12765"
                     /db_xref="CDD:410158"
     CDS             1..271
                     /gene="SRSF5"
                     /gene_synonym="HRS; SFRS5; SRP40"
                     /coded_by="XM_005267999.3:134..949"
                     /db_xref="GeneID:6430"
                     /db_xref="HGNC:HGNC:10787"
                     /db_xref="MIM:600914"
ORIGIN      
        1 msgcrvfigr lnpaarekdv erffkgygri rdidlkrgfg fvefedprda ddavyeldgk
       61 elcservtie hararsrggr grgrysdrfs srrprndrrn appvrtenrl ivenlssrvs
      121 wqdlkdfmrq agevtfadah rpklnegvve fasygdlkna ieklsgkein grkikliegs
      181 krhrsrsrsr srtrsssrsr srsrsrsrks ysrsrsrsrs rsrsksrsvs rspvpeksqk
      241 rgsssrsksp asvdrqrsrs rsrsrsvdsg n
//
LOCUS       XP_016877082             271 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/arginine-rich splicing factor 5 isoform X1 [Homo sapiens].
ACCESSION   XP_016877082
VERSION     XP_016877082.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021593.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..271
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..271
                     /product="serine/arginine-rich splicing factor 5 isoform
                     X1"
                     /calculated_mol_wt=31046
     Region          5..74
                     /region_name="RRM1_SRSF5"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     serine/arginine-rich splicing factor 5 (SRSF5); cd12595"
                     /db_xref="CDD:410008"
     Region          99..179
                     /region_name="RRM2_SRSF5"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     serine/arginine-rich splicing factor 5 (SRSF5); cd12765"
                     /db_xref="CDD:410158"
     CDS             1..271
                     /gene="SRSF5"
                     /gene_synonym="HRS; SFRS5; SRP40"
                     /coded_by="XM_017021593.3:259..1074"
                     /db_xref="GeneID:6430"
                     /db_xref="HGNC:HGNC:10787"
                     /db_xref="MIM:600914"
ORIGIN      
        1 msgcrvfigr lnpaarekdv erffkgygri rdidlkrgfg fvefedprda ddavyeldgk
       61 elcservtie hararsrggr grgrysdrfs srrprndrrn appvrtenrl ivenlssrvs
      121 wqdlkdfmrq agevtfadah rpklnegvve fasygdlkna ieklsgkein grkikliegs
      181 krhrsrsrsr srtrsssrsr srsrsrsrks ysrsrsrsrs rsrsksrsvs rspvpeksqk
      241 rgsssrsksp asvdrqrsrs rsrsrsvdsg n
//
LOCUS       XP_005268057             271 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/arginine-rich splicing factor 5 isoform X1 [Homo sapiens].
ACCESSION   XP_005268057
VERSION     XP_005268057.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005268000.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..271
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..271
                     /product="serine/arginine-rich splicing factor 5 isoform
                     X1"
                     /calculated_mol_wt=31046
     Region          5..74
                     /region_name="RRM1_SRSF5"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     serine/arginine-rich splicing factor 5 (SRSF5); cd12595"
                     /db_xref="CDD:410008"
     Region          99..179
                     /region_name="RRM2_SRSF5"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     serine/arginine-rich splicing factor 5 (SRSF5); cd12765"
                     /db_xref="CDD:410158"
     CDS             1..271
                     /gene="SRSF5"
                     /gene_synonym="HRS; SFRS5; SRP40"
                     /coded_by="XM_005268000.3:130..945"
                     /db_xref="GeneID:6430"
                     /db_xref="HGNC:HGNC:10787"
                     /db_xref="MIM:600914"
ORIGIN      
        1 msgcrvfigr lnpaarekdv erffkgygri rdidlkrgfg fvefedprda ddavyeldgk
       61 elcservtie hararsrggr grgrysdrfs srrprndrrn appvrtenrl ivenlssrvs
      121 wqdlkdfmrq agevtfadah rpklnegvve fasygdlkna ieklsgkein grkikliegs
      181 krhrsrsrsr srtrsssrsr srsrsrsrks ysrsrsrsrs rsrsksrsvs rspvpeksqk
      241 rgsssrsksp asvdrqrsrs rsrsrsvdsg n
//
LOCUS       XP_011535379             239 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/arginine-rich splicing factor 5 isoform X2 [Homo sapiens].
ACCESSION   XP_011535379
VERSION     XP_011535379.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537077.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..239
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..239
                     /product="serine/arginine-rich splicing factor 5 isoform
                     X2"
                     /calculated_mol_wt=27208
     Region          5..66
                     /region_name="RRM1_SRSF5"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     serine/arginine-rich splicing factor 5 (SRSF5); cd12595"
                     /db_xref="CDD:410008"
     Region          66..146
                     /region_name="RRM2_SRSF5"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     serine/arginine-rich splicing factor 5 (SRSF5); cd12765"
                     /db_xref="CDD:410158"
     CDS             1..239
                     /gene="SRSF5"
                     /gene_synonym="HRS; SFRS5; SRP40"
                     /coded_by="XM_011537077.4:134..853"
                     /db_xref="GeneID:6430"
                     /db_xref="HGNC:HGNC:10787"
                     /db_xref="MIM:600914"
ORIGIN      
        1 msgcrvfigr lnpaarekdv erffkgygri rdidlkrgfg fvefedprda ddavyeldgk
       61 elcsernapp vrtenrlive nlssrvswqd lkdfmrqage vtfadahrpk lnegvvefas
      121 ygdlknaiek lsgkeingrk ikliegskrh srsrsrsrsr trsssrsrsr srsrsrksys
      181 rsrsrsrsrs rsksrsvsrs pvpeksqkrg sssrskspas vdrqrsrsrs rsrsvdsgn
//
LOCUS       XP_047287639             239 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/arginine-rich splicing factor 5 isoform X2 [Homo sapiens].
ACCESSION   XP_047287639
VERSION     XP_047287639.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431683.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..239
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..239
                     /product="serine/arginine-rich splicing factor 5 isoform
                     X2"
                     /calculated_mol_wt=27208
     Region          5..66
                     /region_name="RRM1_SRSF5"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     serine/arginine-rich splicing factor 5 (SRSF5); cd12595"
                     /db_xref="CDD:410008"
     Region          66..146
                     /region_name="RRM2_SRSF5"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     serine/arginine-rich splicing factor 5 (SRSF5); cd12765"
                     /db_xref="CDD:410158"
     CDS             1..239
                     /gene="SRSF5"
                     /gene_synonym="HRS; SFRS5; SRP40"
                     /coded_by="XM_047431683.1:130..849"
                     /db_xref="GeneID:6430"
                     /db_xref="HGNC:HGNC:10787"
                     /db_xref="MIM:600914"
ORIGIN      
        1 msgcrvfigr lnpaarekdv erffkgygri rdidlkrgfg fvefedprda ddavyeldgk
       61 elcsernapp vrtenrlive nlssrvswqd lkdfmrqage vtfadahrpk lnegvvefas
      121 ygdlknaiek lsgkeingrk ikliegskrh srsrsrsrsr trsssrsrsr srsrsrksys
      181 rsrsrsrsrs rsksrsvsrs pvpeksqkrg sssrskspas vdrqrsrsrs rsrsvdsgn
//
LOCUS       XP_016877083             145 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/arginine-rich splicing factor 5 isoform X3 [Homo sapiens].
ACCESSION   XP_016877083
VERSION     XP_016877083.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021594.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..145
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..145
                     /product="serine/arginine-rich splicing factor 5 isoform
                     X3"
                     /calculated_mol_wt=16297
     Region          <1..52
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:473069"
     CDS             1..145
                     /gene="SRSF5"
                     /gene_synonym="HRS; SFRS5; SRP40"
                     /coded_by="XM_017021594.3:575..1012"
                     /db_xref="GeneID:6430"
                     /db_xref="HGNC:HGNC:10787"
                     /db_xref="MIM:600914"
ORIGIN      
        1 mrqagevtfa dahrpklneg vvefasygdl knaieklsgk eingrkikli egskrhsrsr
       61 srsrsrtrss srsrsrsrsr srksysrsrs rsrsrsrsks rsvsrspvpe ksqkrgsssr
      121 skspasvdrq rsrsrsrsrs vdsgn
//
LOCUS       XP_047287640             138 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/arginine-rich splicing factor 5 isoform X4 [Homo sapiens].
ACCESSION   XP_047287640
VERSION     XP_047287640.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431684.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..138
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..138
                     /product="serine/arginine-rich splicing factor 5 isoform
                     X4"
                     /calculated_mol_wt=15679
     Region          5..74
                     /region_name="RRM1_SRSF5"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     serine/arginine-rich splicing factor 5 (SRSF5); cd12595"
                     /db_xref="CDD:410008"
     Region          99..>122
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:473069"
     CDS             1..138
                     /gene="SRSF5"
                     /gene_synonym="HRS; SFRS5; SRP40"
                     /coded_by="XM_047431684.1:134..550"
                     /db_xref="GeneID:6430"
                     /db_xref="HGNC:HGNC:10787"
                     /db_xref="MIM:600914"
ORIGIN      
        1 msgcrvfigr lnpaarekdv erffkgygri rdidlkrgfg fvefedprda ddavyeldgk
       61 elcservtie hararsrggr grgrysdrfs srrprndrrn appvrtenrl ivenlssrvs
      121 wqpvcvvglm trsacgls
//
LOCUS       XP_047287641             138 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/arginine-rich splicing factor 5 isoform X4 [Homo sapiens].
ACCESSION   XP_047287641
VERSION     XP_047287641.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431685.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..138
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..138
                     /product="serine/arginine-rich splicing factor 5 isoform
                     X4"
                     /calculated_mol_wt=15679
     Region          5..74
                     /region_name="RRM1_SRSF5"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     serine/arginine-rich splicing factor 5 (SRSF5); cd12595"
                     /db_xref="CDD:410008"
     Region          99..>122
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:473069"
     CDS             1..138
                     /gene="SRSF5"
                     /gene_synonym="HRS; SFRS5; SRP40"
                     /coded_by="XM_047431685.1:130..546"
                     /db_xref="GeneID:6430"
                     /db_xref="HGNC:HGNC:10787"
                     /db_xref="MIM:600914"
ORIGIN      
        1 msgcrvfigr lnpaarekdv erffkgygri rdidlkrgfg fvefedprda ddavyeldgk
       61 elcservtie hararsrggr grgrysdrfs srrprndrrn appvrtenrl ivenlssrvs
      121 wqpvcvvglm trsacgls
//
LOCUS       XP_011535380             217 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 253 isoform X1 [Homo sapiens].
ACCESSION   XP_011535380
VERSION     XP_011535380.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537078.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..217
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..217
                     /product="transmembrane protein 253 isoform X1"
                     /calculated_mol_wt=23391
     CDS             1..217
                     /gene="TMEM253"
                     /gene_synonym="C14orf176; C14orf95; NCRNA00220"
                     /coded_by="XM_011537078.3:494..1147"
                     /db_xref="GeneID:643382"
                     /db_xref="HGNC:HGNC:32545"
ORIGIN      
        1 medrageqeq erhslrlekl qhwarhrqsg hllvlavsql wlavvvvpla vsvaclnsdc
       61 hmatalplgp gasglltgtv tlelrraprl wkvrammifn tfnlilgfiv vvvevmktal
      121 gpaptassqh agllvlelsa eaftlggvlv svhalfllsq rkpgccrsqs lhyqelqegf
      181 seleevpgle ngptvastga nervgqreqt raallpp
//
LOCUS       XP_011535381             217 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 253 isoform X1 [Homo sapiens].
ACCESSION   XP_011535381
VERSION     XP_011535381.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537079.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..217
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..217
                     /product="transmembrane protein 253 isoform X1"
                     /calculated_mol_wt=23391
     CDS             1..217
                     /gene="TMEM253"
                     /gene_synonym="C14orf176; C14orf95; NCRNA00220"
                     /coded_by="XM_011537079.3:489..1142"
                     /db_xref="GeneID:643382"
                     /db_xref="HGNC:HGNC:32545"
ORIGIN      
        1 medrageqeq erhslrlekl qhwarhrqsg hllvlavsql wlavvvvpla vsvaclnsdc
       61 hmatalplgp gasglltgtv tlelrraprl wkvrammifn tfnlilgfiv vvvevmktal
      121 gpaptassqh agllvlelsa eaftlggvlv svhalfllsq rkpgccrsqs lhyqelqegf
      181 seleevpgle ngptvastga nervgqreqt raallpp
//
LOCUS       XP_011535385             180 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 253 isoform X2 [Homo sapiens].
ACCESSION   XP_011535385
VERSION     XP_011535385.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537083.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..180
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..180
                     /product="transmembrane protein 253 isoform X2"
                     /calculated_mol_wt=19442
     CDS             1..180
                     /gene="TMEM253"
                     /gene_synonym="C14orf176; C14orf95; NCRNA00220"
                     /coded_by="XM_011537083.3:131..673"
                     /db_xref="GeneID:643382"
                     /db_xref="HGNC:HGNC:32545"
ORIGIN      
        1 medrageqeq erhslrlekl qhwarhrqsg hllvlavsql wlavvvvpla vsvaclnsdc
       61 hmatalplgp gasglltgtv tlelrraprl wkhagllvle lsaeaftlgg vlvsvhalfl
      121 lsqrkpgccr sqslhyqelq egfseleevp glengptvas tganervgqr eqtraallpp
//
LOCUS       XP_011535386             168 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 253 isoform X3 [Homo sapiens].
ACCESSION   XP_011535386
VERSION     XP_011535386.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537084.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..168
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..168
                     /product="transmembrane protein 253 isoform X3"
                     /calculated_mol_wt=18059
     CDS             1..168
                     /gene="TMEM253"
                     /gene_synonym="C14orf176; C14orf95; NCRNA00220"
                     /coded_by="XM_011537084.3:131..637"
                     /db_xref="GeneID:643382"
                     /db_xref="HGNC:HGNC:32545"
ORIGIN      
        1 medrageqeq erhslrlekl qhwarhrqsg hllvlavsql wlavvvvpla vsvaclnsdc
       61 hmatalplgp gasglltgtv tlelrraprl wkvrammifn tfnlilgfiv vvvevmktal
      121 gpaptassqg fseleevpgl engptvastg anervgqreq traallpp
//
LOCUS       XP_011535387             143 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 253 isoform X4 [Homo sapiens].
ACCESSION   XP_011535387
VERSION     XP_011535387.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537085.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..143
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..143
                     /product="transmembrane protein 253 isoform X4"
                     /calculated_mol_wt=15770
     CDS             1..143
                     /gene="TMEM253"
                     /gene_synonym="C14orf176; C14orf95; NCRNA00220"
                     /coded_by="XM_011537085.3:131..562"
                     /db_xref="GeneID:643382"
                     /db_xref="HGNC:HGNC:32545"
ORIGIN      
        1 medrageqeq erhslrlekl qhwarhrqsg hllvlagllt gtvtlelrra prlwkhagll
       61 vlelsaeaft lggvlvsvha lfllsqrkpg ccrsqslhyq elqegfsele evpglengpt
      121 vastganerv gqreqtraal lpp
//
LOCUS       XP_047287645             131 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 253 isoform X5 [Homo sapiens].
ACCESSION   XP_047287645
VERSION     XP_047287645.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431689.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..131
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..131
                     /product="transmembrane protein 253 isoform X5"
                     /calculated_mol_wt=14387
     CDS             1..131
                     /gene="TMEM253"
                     /gene_synonym="C14orf176; C14orf95; NCRNA00220"
                     /coded_by="XM_047431689.1:131..526"
                     /db_xref="GeneID:643382"
                     /db_xref="HGNC:HGNC:32545"
ORIGIN      
        1 medrageqeq erhslrlekl qhwarhrqsg hllvlagllt gtvtlelrra prlwkvramm
       61 ifntfnlilg fivvvvevmk talgpaptas sqgfseleev pglengptva stganervgq
      121 reqtraallp p
//
LOCUS       XP_011535389             675 aa            linear   PRI 05-AUG-2025
DEFINITION  protein PALS1 isoform X1 [Homo sapiens].
ACCESSION   XP_011535389
VERSION     XP_011535389.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537087.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..675
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..675
                     /product="protein PALS1 isoform X1"
                     /calculated_mol_wt=77163
     Region          123..170
                     /region_name="L27_N"
                     /note="pfam09060"
                     /db_xref="CDD:462666"
     Region          189..237
                     /region_name="L27"
                     /note="domain in receptor targeting proteins Lin-2 and
                     Lin-7; smart00569"
                     /db_xref="CDD:197794"
     Region          255..334
                     /region_name="PDZ_MPP5-like"
                     /note="PDZ domain of membrane palmitoylated protein 5
                     (MPP5), Drosophila Stardust, and related domains; cd06798"
                     /db_xref="CDD:467259"
     Site            order(266..272,281,284,314,318,321..322)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467259"
     Region          349..411
                     /region_name="SH3_MPP5"
                     /note="Src Homology 3 domain of Membrane Protein,
                     Palmitoylated 5 (or MAGUK p55 subfamily member 5);
                     cd12036"
                     /db_xref="CDD:212969"
     Site            order(351,375..376)
                     /site_type="other"
                     /note="GuK domain interface [polypeptide binding]"
                     /db_xref="CDD:212969"
     Site            order(354,356,359,370,388..389,408,410..411)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212969"
     Site            order(486,492,509,516,519,528,551,556)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:238026"
     Site            order(486,492)
                     /site_type="other"
                     /note="G-X2-G-X-G-K"
                     /db_xref="CDD:238026"
     Region          491..661
                     /region_name="GuKc"
                     /note="Guanylate kinase homologues; smart00072"
                     /db_xref="CDD:214504"
     CDS             1..675
                     /gene="PALS1"
                     /gene_synonym="MPP5"
                     /coded_by="XM_011537087.3:549..2576"
                     /db_xref="GeneID:64398"
                     /db_xref="HGNC:HGNC:18669"
                     /db_xref="MIM:606958"
ORIGIN      
        1 mttshmnghv teesdsevkn vdlaspeehq khremavdcp gdlgtrmmpi rrsaqlerir
       61 qqqedmrrrr eeegkkqeld lnssmrlkkl aqippktgid npmfdteegi vlesphyavk
      121 ileiedlfss lkhiqhtlvd sqsqedisll lqlvqnkdfq nafkihnait vhmnkasppf
      181 plisnaqdla qevqtvlkpv hhkegqelta llntphiqal llahdkvaeq emqlepitde
      241 rvyesigqyg getvkivrie kardiplgat vrnemdsvii srivkggaae ksgllhegde
      301 vleingieir gkdvnevfdl lsdmhgtltf vlipsqqikp ppaketvihv kahfdydpsd
      361 dpyvpcrelg lsfqkgdilh visqedpnww qayregdedn qplaglvpgk sfqqqreamk
      421 qtieedkepe ksgklwcakk nkkkrkkvly nanknddydn eeiltyeems lyhqpanrkr
      481 piiligpqnc gqnelrqrlm nkekdrfasa vphttrsrrd qevagrdyhf vsrqafeadi
      541 aagkfiehge feknlygtsi dsvrqvinsg kicllslrtq slktlrnsdl kpyiifiapp
      601 sqerlralla kegknpkpee lreiiektre meqnnghyfd taivnsdldk ayqellrlin
      661 kldtepqwvp stwlr
//
LOCUS       XP_011535388             675 aa            linear   PRI 05-AUG-2025
DEFINITION  protein PALS1 isoform X1 [Homo sapiens].
ACCESSION   XP_011535388
VERSION     XP_011535388.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537086.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..675
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..675
                     /product="protein PALS1 isoform X1"
                     /calculated_mol_wt=77163
     Region          123..170
                     /region_name="L27_N"
                     /note="pfam09060"
                     /db_xref="CDD:462666"
     Region          189..237
                     /region_name="L27"
                     /note="domain in receptor targeting proteins Lin-2 and
                     Lin-7; smart00569"
                     /db_xref="CDD:197794"
     Region          255..334
                     /region_name="PDZ_MPP5-like"
                     /note="PDZ domain of membrane palmitoylated protein 5
                     (MPP5), Drosophila Stardust, and related domains; cd06798"
                     /db_xref="CDD:467259"
     Site            order(266..272,281,284,314,318,321..322)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467259"
     Region          349..411
                     /region_name="SH3_MPP5"
                     /note="Src Homology 3 domain of Membrane Protein,
                     Palmitoylated 5 (or MAGUK p55 subfamily member 5);
                     cd12036"
                     /db_xref="CDD:212969"
     Site            order(351,375..376)
                     /site_type="other"
                     /note="GuK domain interface [polypeptide binding]"
                     /db_xref="CDD:212969"
     Site            order(354,356,359,370,388..389,408,410..411)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212969"
     Site            order(486,492,509,516,519,528,551,556)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:238026"
     Site            order(486,492)
                     /site_type="other"
                     /note="G-X2-G-X-G-K"
                     /db_xref="CDD:238026"
     Region          491..661
                     /region_name="GuKc"
                     /note="Guanylate kinase homologues; smart00072"
                     /db_xref="CDD:214504"
     CDS             1..675
                     /gene="PALS1"
                     /gene_synonym="MPP5"
                     /coded_by="XM_011537086.3:443..2470"
                     /db_xref="GeneID:64398"
                     /db_xref="HGNC:HGNC:18669"
                     /db_xref="MIM:606958"
ORIGIN      
        1 mttshmnghv teesdsevkn vdlaspeehq khremavdcp gdlgtrmmpi rrsaqlerir
       61 qqqedmrrrr eeegkkqeld lnssmrlkkl aqippktgid npmfdteegi vlesphyavk
      121 ileiedlfss lkhiqhtlvd sqsqedisll lqlvqnkdfq nafkihnait vhmnkasppf
      181 plisnaqdla qevqtvlkpv hhkegqelta llntphiqal llahdkvaeq emqlepitde
      241 rvyesigqyg getvkivrie kardiplgat vrnemdsvii srivkggaae ksgllhegde
      301 vleingieir gkdvnevfdl lsdmhgtltf vlipsqqikp ppaketvihv kahfdydpsd
      361 dpyvpcrelg lsfqkgdilh visqedpnww qayregdedn qplaglvpgk sfqqqreamk
      421 qtieedkepe ksgklwcakk nkkkrkkvly nanknddydn eeiltyeems lyhqpanrkr
      481 piiligpqnc gqnelrqrlm nkekdrfasa vphttrsrrd qevagrdyhf vsrqafeadi
      541 aagkfiehge feknlygtsi dsvrqvinsg kicllslrtq slktlrnsdl kpyiifiapp
      601 sqerlralla kegknpkpee lreiiektre meqnnghyfd taivnsdldk ayqellrlin
      661 kldtepqwvp stwlr
//
LOCUS       XP_047287646             675 aa            linear   PRI 05-AUG-2025
DEFINITION  protein PALS1 isoform X1 [Homo sapiens].
ACCESSION   XP_047287646
VERSION     XP_047287646.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431690.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..675
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..675
                     /product="protein PALS1 isoform X1"
                     /calculated_mol_wt=77163
     Region          123..170
                     /region_name="L27_N"
                     /note="pfam09060"
                     /db_xref="CDD:462666"
     Region          189..237
                     /region_name="L27"
                     /note="domain in receptor targeting proteins Lin-2 and
                     Lin-7; smart00569"
                     /db_xref="CDD:197794"
     Region          255..334
                     /region_name="PDZ_MPP5-like"
                     /note="PDZ domain of membrane palmitoylated protein 5
                     (MPP5), Drosophila Stardust, and related domains; cd06798"
                     /db_xref="CDD:467259"
     Site            order(266..272,281,284,314,318,321..322)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467259"
     Region          349..411
                     /region_name="SH3_MPP5"
                     /note="Src Homology 3 domain of Membrane Protein,
                     Palmitoylated 5 (or MAGUK p55 subfamily member 5);
                     cd12036"
                     /db_xref="CDD:212969"
     Site            order(351,375..376)
                     /site_type="other"
                     /note="GuK domain interface [polypeptide binding]"
                     /db_xref="CDD:212969"
     Site            order(354,356,359,370,388..389,408,410..411)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212969"
     Site            order(486,492,509,516,519,528,551,556)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:238026"
     Site            order(486,492)
                     /site_type="other"
                     /note="G-X2-G-X-G-K"
                     /db_xref="CDD:238026"
     Region          491..661
                     /region_name="GuKc"
                     /note="Guanylate kinase homologues; smart00072"
                     /db_xref="CDD:214504"
     CDS             1..675
                     /gene="PALS1"
                     /gene_synonym="MPP5"
                     /coded_by="XM_047431690.1:656..2683"
                     /db_xref="GeneID:64398"
                     /db_xref="HGNC:HGNC:18669"
                     /db_xref="MIM:606958"
ORIGIN      
        1 mttshmnghv teesdsevkn vdlaspeehq khremavdcp gdlgtrmmpi rrsaqlerir
       61 qqqedmrrrr eeegkkqeld lnssmrlkkl aqippktgid npmfdteegi vlesphyavk
      121 ileiedlfss lkhiqhtlvd sqsqedisll lqlvqnkdfq nafkihnait vhmnkasppf
      181 plisnaqdla qevqtvlkpv hhkegqelta llntphiqal llahdkvaeq emqlepitde
      241 rvyesigqyg getvkivrie kardiplgat vrnemdsvii srivkggaae ksgllhegde
      301 vleingieir gkdvnevfdl lsdmhgtltf vlipsqqikp ppaketvihv kahfdydpsd
      361 dpyvpcrelg lsfqkgdilh visqedpnww qayregdedn qplaglvpgk sfqqqreamk
      421 qtieedkepe ksgklwcakk nkkkrkkvly nanknddydn eeiltyeems lyhqpanrkr
      481 piiligpqnc gqnelrqrlm nkekdrfasa vphttrsrrd qevagrdyhf vsrqafeadi
      541 aagkfiehge feknlygtsi dsvrqvinsg kicllslrtq slktlrnsdl kpyiifiapp
      601 sqerlralla kegknpkpee lreiiektre meqnnghyfd taivnsdldk ayqellrlin
      661 kldtepqwvp stwlr
//
LOCUS       XP_047287647             675 aa            linear   PRI 05-AUG-2025
DEFINITION  protein PALS1 isoform X1 [Homo sapiens].
ACCESSION   XP_047287647
VERSION     XP_047287647.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431691.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..675
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..675
                     /product="protein PALS1 isoform X1"
                     /calculated_mol_wt=77163
     Region          123..170
                     /region_name="L27_N"
                     /note="pfam09060"
                     /db_xref="CDD:462666"
     Region          189..237
                     /region_name="L27"
                     /note="domain in receptor targeting proteins Lin-2 and
                     Lin-7; smart00569"
                     /db_xref="CDD:197794"
     Region          255..334
                     /region_name="PDZ_MPP5-like"
                     /note="PDZ domain of membrane palmitoylated protein 5
                     (MPP5), Drosophila Stardust, and related domains; cd06798"
                     /db_xref="CDD:467259"
     Site            order(266..272,281,284,314,318,321..322)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467259"
     Region          349..411
                     /region_name="SH3_MPP5"
                     /note="Src Homology 3 domain of Membrane Protein,
                     Palmitoylated 5 (or MAGUK p55 subfamily member 5);
                     cd12036"
                     /db_xref="CDD:212969"
     Site            order(351,375..376)
                     /site_type="other"
                     /note="GuK domain interface [polypeptide binding]"
                     /db_xref="CDD:212969"
     Site            order(354,356,359,370,388..389,408,410..411)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212969"
     Site            order(486,492,509,516,519,528,551,556)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:238026"
     Site            order(486,492)
                     /site_type="other"
                     /note="G-X2-G-X-G-K"
                     /db_xref="CDD:238026"
     Region          491..661
                     /region_name="GuKc"
                     /note="Guanylate kinase homologues; smart00072"
                     /db_xref="CDD:214504"
     CDS             1..675
                     /gene="PALS1"
                     /gene_synonym="MPP5"
                     /coded_by="XM_047431691.1:385..2412"
                     /db_xref="GeneID:64398"
                     /db_xref="HGNC:HGNC:18669"
                     /db_xref="MIM:606958"
ORIGIN      
        1 mttshmnghv teesdsevkn vdlaspeehq khremavdcp gdlgtrmmpi rrsaqlerir
       61 qqqedmrrrr eeegkkqeld lnssmrlkkl aqippktgid npmfdteegi vlesphyavk
      121 ileiedlfss lkhiqhtlvd sqsqedisll lqlvqnkdfq nafkihnait vhmnkasppf
      181 plisnaqdla qevqtvlkpv hhkegqelta llntphiqal llahdkvaeq emqlepitde
      241 rvyesigqyg getvkivrie kardiplgat vrnemdsvii srivkggaae ksgllhegde
      301 vleingieir gkdvnevfdl lsdmhgtltf vlipsqqikp ppaketvihv kahfdydpsd
      361 dpyvpcrelg lsfqkgdilh visqedpnww qayregdedn qplaglvpgk sfqqqreamk
      421 qtieedkepe ksgklwcakk nkkkrkkvly nanknddydn eeiltyeems lyhqpanrkr
      481 piiligpqnc gqnelrqrlm nkekdrfasa vphttrsrrd qevagrdyhf vsrqafeadi
      541 aagkfiehge feknlygtsi dsvrqvinsg kicllslrtq slktlrnsdl kpyiifiapp
      601 sqerlralla kegknpkpee lreiiektre meqnnghyfd taivnsdldk ayqellrlin
      661 kldtepqwvp stwlr
//
LOCUS       XP_047287648             675 aa            linear   PRI 05-AUG-2025
DEFINITION  protein PALS1 isoform X1 [Homo sapiens].
ACCESSION   XP_047287648
VERSION     XP_047287648.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431692.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..675
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..675
                     /product="protein PALS1 isoform X1"
                     /calculated_mol_wt=77163
     Region          123..170
                     /region_name="L27_N"
                     /note="pfam09060"
                     /db_xref="CDD:462666"
     Region          189..237
                     /region_name="L27"
                     /note="domain in receptor targeting proteins Lin-2 and
                     Lin-7; smart00569"
                     /db_xref="CDD:197794"
     Region          255..334
                     /region_name="PDZ_MPP5-like"
                     /note="PDZ domain of membrane palmitoylated protein 5
                     (MPP5), Drosophila Stardust, and related domains; cd06798"
                     /db_xref="CDD:467259"
     Site            order(266..272,281,284,314,318,321..322)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467259"
     Region          349..411
                     /region_name="SH3_MPP5"
                     /note="Src Homology 3 domain of Membrane Protein,
                     Palmitoylated 5 (or MAGUK p55 subfamily member 5);
                     cd12036"
                     /db_xref="CDD:212969"
     Site            order(351,375..376)
                     /site_type="other"
                     /note="GuK domain interface [polypeptide binding]"
                     /db_xref="CDD:212969"
     Site            order(354,356,359,370,388..389,408,410..411)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212969"
     Site            order(486,492,509,516,519,528,551,556)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:238026"
     Site            order(486,492)
                     /site_type="other"
                     /note="G-X2-G-X-G-K"
                     /db_xref="CDD:238026"
     Region          491..661
                     /region_name="GuKc"
                     /note="Guanylate kinase homologues; smart00072"
                     /db_xref="CDD:214504"
     CDS             1..675
                     /gene="PALS1"
                     /gene_synonym="MPP5"
                     /coded_by="XM_047431692.1:902..2929"
                     /db_xref="GeneID:64398"
                     /db_xref="HGNC:HGNC:18669"
                     /db_xref="MIM:606958"
ORIGIN      
        1 mttshmnghv teesdsevkn vdlaspeehq khremavdcp gdlgtrmmpi rrsaqlerir
       61 qqqedmrrrr eeegkkqeld lnssmrlkkl aqippktgid npmfdteegi vlesphyavk
      121 ileiedlfss lkhiqhtlvd sqsqedisll lqlvqnkdfq nafkihnait vhmnkasppf
      181 plisnaqdla qevqtvlkpv hhkegqelta llntphiqal llahdkvaeq emqlepitde
      241 rvyesigqyg getvkivrie kardiplgat vrnemdsvii srivkggaae ksgllhegde
      301 vleingieir gkdvnevfdl lsdmhgtltf vlipsqqikp ppaketvihv kahfdydpsd
      361 dpyvpcrelg lsfqkgdilh visqedpnww qayregdedn qplaglvpgk sfqqqreamk
      421 qtieedkepe ksgklwcakk nkkkrkkvly nanknddydn eeiltyeems lyhqpanrkr
      481 piiligpqnc gqnelrqrlm nkekdrfasa vphttrsrrd qevagrdyhf vsrqafeadi
      541 aagkfiehge feknlygtsi dsvrqvinsg kicllslrtq slktlrnsdl kpyiifiapp
      601 sqerlralla kegknpkpee lreiiektre meqnnghyfd taivnsdldk ayqellrlin
      661 kldtepqwvp stwlr
//
LOCUS       XP_047287649             675 aa            linear   PRI 05-AUG-2025
DEFINITION  protein PALS1 isoform X1 [Homo sapiens].
ACCESSION   XP_047287649
VERSION     XP_047287649.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431693.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..675
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..675
                     /product="protein PALS1 isoform X1"
                     /calculated_mol_wt=77163
     Region          123..170
                     /region_name="L27_N"
                     /note="pfam09060"
                     /db_xref="CDD:462666"
     Region          189..237
                     /region_name="L27"
                     /note="domain in receptor targeting proteins Lin-2 and
                     Lin-7; smart00569"
                     /db_xref="CDD:197794"
     Region          255..334
                     /region_name="PDZ_MPP5-like"
                     /note="PDZ domain of membrane palmitoylated protein 5
                     (MPP5), Drosophila Stardust, and related domains; cd06798"
                     /db_xref="CDD:467259"
     Site            order(266..272,281,284,314,318,321..322)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467259"
     Region          349..411
                     /region_name="SH3_MPP5"
                     /note="Src Homology 3 domain of Membrane Protein,
                     Palmitoylated 5 (or MAGUK p55 subfamily member 5);
                     cd12036"
                     /db_xref="CDD:212969"
     Site            order(351,375..376)
                     /site_type="other"
                     /note="GuK domain interface [polypeptide binding]"
                     /db_xref="CDD:212969"
     Site            order(354,356,359,370,388..389,408,410..411)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212969"
     Site            order(486,492,509,516,519,528,551,556)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:238026"
     Site            order(486,492)
                     /site_type="other"
                     /note="G-X2-G-X-G-K"
                     /db_xref="CDD:238026"
     Region          491..661
                     /region_name="GuKc"
                     /note="Guanylate kinase homologues; smart00072"
                     /db_xref="CDD:214504"
     CDS             1..675
                     /gene="PALS1"
                     /gene_synonym="MPP5"
                     /coded_by="XM_047431693.1:1115..3142"
                     /db_xref="GeneID:64398"
                     /db_xref="HGNC:HGNC:18669"
                     /db_xref="MIM:606958"
ORIGIN      
        1 mttshmnghv teesdsevkn vdlaspeehq khremavdcp gdlgtrmmpi rrsaqlerir
       61 qqqedmrrrr eeegkkqeld lnssmrlkkl aqippktgid npmfdteegi vlesphyavk
      121 ileiedlfss lkhiqhtlvd sqsqedisll lqlvqnkdfq nafkihnait vhmnkasppf
      181 plisnaqdla qevqtvlkpv hhkegqelta llntphiqal llahdkvaeq emqlepitde
      241 rvyesigqyg getvkivrie kardiplgat vrnemdsvii srivkggaae ksgllhegde
      301 vleingieir gkdvnevfdl lsdmhgtltf vlipsqqikp ppaketvihv kahfdydpsd
      361 dpyvpcrelg lsfqkgdilh visqedpnww qayregdedn qplaglvpgk sfqqqreamk
      421 qtieedkepe ksgklwcakk nkkkrkkvly nanknddydn eeiltyeems lyhqpanrkr
      481 piiligpqnc gqnelrqrlm nkekdrfasa vphttrsrrd qevagrdyhf vsrqafeadi
      541 aagkfiehge feknlygtsi dsvrqvinsg kicllslrtq slktlrnsdl kpyiifiapp
      601 sqerlralla kegknpkpee lreiiektre meqnnghyfd taivnsdldk ayqellrlin
      661 kldtepqwvp stwlr
//
LOCUS       XP_024305459             641 aa            linear   PRI 05-AUG-2025
DEFINITION  protein PALS1 isoform X2 [Homo sapiens].
ACCESSION   XP_024305459
VERSION     XP_024305459.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449691.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..641
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..641
                     /product="protein PALS1 isoform X2"
                     /calculated_mol_wt=73291
     Region          89..136
                     /region_name="L27_N"
                     /note="pfam09060"
                     /db_xref="CDD:462666"
     Region          155..203
                     /region_name="L27"
                     /note="domain in receptor targeting proteins Lin-2 and
                     Lin-7; smart00569"
                     /db_xref="CDD:197794"
     Region          221..300
                     /region_name="PDZ_MPP5-like"
                     /note="PDZ domain of membrane palmitoylated protein 5
                     (MPP5), Drosophila Stardust, and related domains; cd06798"
                     /db_xref="CDD:467259"
     Site            order(232..238,247,250,280,284,287..288)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467259"
     Region          315..377
                     /region_name="SH3_MPP5"
                     /note="Src Homology 3 domain of Membrane Protein,
                     Palmitoylated 5 (or MAGUK p55 subfamily member 5);
                     cd12036"
                     /db_xref="CDD:212969"
     Site            order(317,341..342)
                     /site_type="other"
                     /note="GuK domain interface [polypeptide binding]"
                     /db_xref="CDD:212969"
     Site            order(320,322,325,336,354..355,374,376..377)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212969"
     Site            order(452,458,475,482,485,494,517,522)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:238026"
     Site            order(452,458)
                     /site_type="other"
                     /note="G-X2-G-X-G-K"
                     /db_xref="CDD:238026"
     Region          457..627
                     /region_name="GuKc"
                     /note="Guanylate kinase homologues; smart00072"
                     /db_xref="CDD:214504"
     CDS             1..641
                     /gene="PALS1"
                     /gene_synonym="MPP5"
                     /coded_by="XM_024449691.2:313..2238"
                     /db_xref="GeneID:64398"
                     /db_xref="HGNC:HGNC:18669"
                     /db_xref="MIM:606958"
ORIGIN      
        1 mavdcpgdlg trmmpirrsa qlerirqqqe dmrrrreeeg kkqeldlnss mrlkklaqip
       61 pktgidnpmf dteegivles phyavkilei edlfsslkhi qhtlvdsqsq edislllqlv
      121 qnkdfqnafk ihnaitvhmn kasppfplis naqdlaqevq tvlkpvhhke gqeltallnt
      181 phiqalllah dkvaeqemql epitdervye sigqyggetv kivriekard iplgatvrne
      241 mdsviisriv kggaaeksgl lhegdevlei ngieirgkdv nevfdllsdm hgtltfvlip
      301 sqqikpppak etvihvkahf dydpsddpyv pcrelglsfq kgdilhvisq edpnwwqayr
      361 egdednqpla glvpgksfqq qreamkqtie edkepeksgk lwcakknkkk rkkvlynank
      421 nddydneeil tyeemslyhq panrkrpiil igpqncgqne lrqrlmnkek drfasavpht
      481 trsrrdqeva grdyhfvsrq afeadiaagk fiehgefekn lygtsidsvr qvinsgkicl
      541 lslrtqslkt lrnsdlkpyi ifiappsqer lrallakegk npkpeelrei iektremeqn
      601 nghyfdtaiv nsdldkayqe llrlinkldt epqwvpstwl r
//
LOCUS       XP_005268060             641 aa            linear   PRI 05-AUG-2025
DEFINITION  protein PALS1 isoform X2 [Homo sapiens].
ACCESSION   XP_005268060
VERSION     XP_005268060.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005268003.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..641
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..641
                     /product="protein PALS1 isoform X2"
                     /calculated_mol_wt=73291
     Region          89..136
                     /region_name="L27_N"
                     /note="pfam09060"
                     /db_xref="CDD:462666"
     Region          155..203
                     /region_name="L27"
                     /note="domain in receptor targeting proteins Lin-2 and
                     Lin-7; smart00569"
                     /db_xref="CDD:197794"
     Region          221..300
                     /region_name="PDZ_MPP5-like"
                     /note="PDZ domain of membrane palmitoylated protein 5
                     (MPP5), Drosophila Stardust, and related domains; cd06798"
                     /db_xref="CDD:467259"
     Site            order(232..238,247,250,280,284,287..288)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467259"
     Region          315..377
                     /region_name="SH3_MPP5"
                     /note="Src Homology 3 domain of Membrane Protein,
                     Palmitoylated 5 (or MAGUK p55 subfamily member 5);
                     cd12036"
                     /db_xref="CDD:212969"
     Site            order(317,341..342)
                     /site_type="other"
                     /note="GuK domain interface [polypeptide binding]"
                     /db_xref="CDD:212969"
     Site            order(320,322,325,336,354..355,374,376..377)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212969"
     Site            order(452,458,475,482,485,494,517,522)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:238026"
     Site            order(452,458)
                     /site_type="other"
                     /note="G-X2-G-X-G-K"
                     /db_xref="CDD:238026"
     Region          457..627
                     /region_name="GuKc"
                     /note="Guanylate kinase homologues; smart00072"
                     /db_xref="CDD:214504"
     CDS             1..641
                     /gene="PALS1"
                     /gene_synonym="MPP5"
                     /coded_by="XM_005268003.2:419..2344"
                     /db_xref="GeneID:64398"
                     /db_xref="HGNC:HGNC:18669"
                     /db_xref="MIM:606958"
ORIGIN      
        1 mavdcpgdlg trmmpirrsa qlerirqqqe dmrrrreeeg kkqeldlnss mrlkklaqip
       61 pktgidnpmf dteegivles phyavkilei edlfsslkhi qhtlvdsqsq edislllqlv
      121 qnkdfqnafk ihnaitvhmn kasppfplis naqdlaqevq tvlkpvhhke gqeltallnt
      181 phiqalllah dkvaeqemql epitdervye sigqyggetv kivriekard iplgatvrne
      241 mdsviisriv kggaaeksgl lhegdevlei ngieirgkdv nevfdllsdm hgtltfvlip
      301 sqqikpppak etvihvkahf dydpsddpyv pcrelglsfq kgdilhvisq edpnwwqayr
      361 egdednqpla glvpgksfqq qreamkqtie edkepeksgk lwcakknkkk rkkvlynank
      421 nddydneeil tyeemslyhq panrkrpiil igpqncgqne lrqrlmnkek drfasavpht
      481 trsrrdqeva grdyhfvsrq afeadiaagk fiehgefekn lygtsidsvr qvinsgkicl
      541 lslrtqslkt lrnsdlkpyi ifiappsqer lrallakegk npkpeelrei iektremeqn
      601 nghyfdtaiv nsdldkayqe llrlinkldt epqwvpstwl r
//
LOCUS       XP_047287651             641 aa            linear   PRI 05-AUG-2025
DEFINITION  protein PALS1 isoform X2 [Homo sapiens].
ACCESSION   XP_047287651
VERSION     XP_047287651.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431695.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..641
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..641
                     /product="protein PALS1 isoform X2"
                     /calculated_mol_wt=73291
     Region          89..136
                     /region_name="L27_N"
                     /note="pfam09060"
                     /db_xref="CDD:462666"
     Region          155..203
                     /region_name="L27"
                     /note="domain in receptor targeting proteins Lin-2 and
                     Lin-7; smart00569"
                     /db_xref="CDD:197794"
     Region          221..300
                     /region_name="PDZ_MPP5-like"
                     /note="PDZ domain of membrane palmitoylated protein 5
                     (MPP5), Drosophila Stardust, and related domains; cd06798"
                     /db_xref="CDD:467259"
     Site            order(232..238,247,250,280,284,287..288)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467259"
     Region          315..377
                     /region_name="SH3_MPP5"
                     /note="Src Homology 3 domain of Membrane Protein,
                     Palmitoylated 5 (or MAGUK p55 subfamily member 5);
                     cd12036"
                     /db_xref="CDD:212969"
     Site            order(317,341..342)
                     /site_type="other"
                     /note="GuK domain interface [polypeptide binding]"
                     /db_xref="CDD:212969"
     Site            order(320,322,325,336,354..355,374,376..377)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212969"
     Site            order(452,458,475,482,485,494,517,522)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:238026"
     Site            order(452,458)
                     /site_type="other"
                     /note="G-X2-G-X-G-K"
                     /db_xref="CDD:238026"
     Region          457..627
                     /region_name="GuKc"
                     /note="Guanylate kinase homologues; smart00072"
                     /db_xref="CDD:214504"
     CDS             1..641
                     /gene="PALS1"
                     /gene_synonym="MPP5"
                     /coded_by="XM_047431695.1:526..2451"
                     /db_xref="GeneID:64398"
                     /db_xref="HGNC:HGNC:18669"
                     /db_xref="MIM:606958"
ORIGIN      
        1 mavdcpgdlg trmmpirrsa qlerirqqqe dmrrrreeeg kkqeldlnss mrlkklaqip
       61 pktgidnpmf dteegivles phyavkilei edlfsslkhi qhtlvdsqsq edislllqlv
      121 qnkdfqnafk ihnaitvhmn kasppfplis naqdlaqevq tvlkpvhhke gqeltallnt
      181 phiqalllah dkvaeqemql epitdervye sigqyggetv kivriekard iplgatvrne
      241 mdsviisriv kggaaeksgl lhegdevlei ngieirgkdv nevfdllsdm hgtltfvlip
      301 sqqikpppak etvihvkahf dydpsddpyv pcrelglsfq kgdilhvisq edpnwwqayr
      361 egdednqpla glvpgksfqq qreamkqtie edkepeksgk lwcakknkkk rkkvlynank
      421 nddydneeil tyeemslyhq panrkrpiil igpqncgqne lrqrlmnkek drfasavpht
      481 trsrrdqeva grdyhfvsrq afeadiaagk fiehgefekn lygtsidsvr qvinsgkicl
      541 lslrtqslkt lrnsdlkpyi ifiappsqer lrallakegk npkpeelrei iektremeqn
      601 nghyfdtaiv nsdldkayqe llrlinkldt epqwvpstwl r
//
LOCUS       XP_024305460             641 aa            linear   PRI 05-AUG-2025
DEFINITION  protein PALS1 isoform X2 [Homo sapiens].
ACCESSION   XP_024305460
VERSION     XP_024305460.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449692.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..641
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..641
                     /product="protein PALS1 isoform X2"
                     /calculated_mol_wt=73291
     Region          89..136
                     /region_name="L27_N"
                     /note="pfam09060"
                     /db_xref="CDD:462666"
     Region          155..203
                     /region_name="L27"
                     /note="domain in receptor targeting proteins Lin-2 and
                     Lin-7; smart00569"
                     /db_xref="CDD:197794"
     Region          221..300
                     /region_name="PDZ_MPP5-like"
                     /note="PDZ domain of membrane palmitoylated protein 5
                     (MPP5), Drosophila Stardust, and related domains; cd06798"
                     /db_xref="CDD:467259"
     Site            order(232..238,247,250,280,284,287..288)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467259"
     Region          315..377
                     /region_name="SH3_MPP5"
                     /note="Src Homology 3 domain of Membrane Protein,
                     Palmitoylated 5 (or MAGUK p55 subfamily member 5);
                     cd12036"
                     /db_xref="CDD:212969"
     Site            order(317,341..342)
                     /site_type="other"
                     /note="GuK domain interface [polypeptide binding]"
                     /db_xref="CDD:212969"
     Site            order(320,322,325,336,354..355,374,376..377)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212969"
     Site            order(452,458,475,482,485,494,517,522)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:238026"
     Site            order(452,458)
                     /site_type="other"
                     /note="G-X2-G-X-G-K"
                     /db_xref="CDD:238026"
     Region          457..627
                     /region_name="GuKc"
                     /note="Guanylate kinase homologues; smart00072"
                     /db_xref="CDD:214504"
     CDS             1..641
                     /gene="PALS1"
                     /gene_synonym="MPP5"
                     /coded_by="XM_024449692.2:154..2079"
                     /db_xref="GeneID:64398"
                     /db_xref="HGNC:HGNC:18669"
                     /db_xref="MIM:606958"
ORIGIN      
        1 mavdcpgdlg trmmpirrsa qlerirqqqe dmrrrreeeg kkqeldlnss mrlkklaqip
       61 pktgidnpmf dteegivles phyavkilei edlfsslkhi qhtlvdsqsq edislllqlv
      121 qnkdfqnafk ihnaitvhmn kasppfplis naqdlaqevq tvlkpvhhke gqeltallnt
      181 phiqalllah dkvaeqemql epitdervye sigqyggetv kivriekard iplgatvrne
      241 mdsviisriv kggaaeksgl lhegdevlei ngieirgkdv nevfdllsdm hgtltfvlip
      301 sqqikpppak etvihvkahf dydpsddpyv pcrelglsfq kgdilhvisq edpnwwqayr
      361 egdednqpla glvpgksfqq qreamkqtie edkepeksgk lwcakknkkk rkkvlynank
      421 nddydneeil tyeemslyhq panrkrpiil igpqncgqne lrqrlmnkek drfasavpht
      481 trsrrdqeva grdyhfvsrq afeadiaagk fiehgefekn lygtsidsvr qvinsgkicl
      541 lslrtqslkt lrnsdlkpyi ifiappsqer lrallakegk npkpeelrei iektremeqn
      601 nghyfdtaiv nsdldkayqe llrlinkldt epqwvpstwl r
//
LOCUS       XP_047287652             503 aa            linear   PRI 05-AUG-2025
DEFINITION  protein PALS1 isoform X3 [Homo sapiens].
ACCESSION   XP_047287652
VERSION     XP_047287652.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431696.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..503
                     /product="protein PALS1 isoform X3"
                     /calculated_mol_wt=57318
     Region          17..65
                     /region_name="L27"
                     /note="domain in receptor targeting proteins Lin-2 and
                     Lin-7; smart00569"
                     /db_xref="CDD:197794"
     Region          83..162
                     /region_name="PDZ_MPP5-like"
                     /note="PDZ domain of membrane palmitoylated protein 5
                     (MPP5), Drosophila Stardust, and related domains; cd06798"
                     /db_xref="CDD:467259"
     Site            order(94..100,109,112,142,146,149..150)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467259"
     Region          177..239
                     /region_name="SH3_MPP5"
                     /note="Src Homology 3 domain of Membrane Protein,
                     Palmitoylated 5 (or MAGUK p55 subfamily member 5);
                     cd12036"
                     /db_xref="CDD:212969"
     Site            order(179,203..204)
                     /site_type="other"
                     /note="GuK domain interface [polypeptide binding]"
                     /db_xref="CDD:212969"
     Site            order(182,184,187,198,216..217,236,238..239)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212969"
     Site            order(314,320,337,344,347,356,379,384)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:238026"
     Site            order(314,320)
                     /site_type="other"
                     /note="G-X2-G-X-G-K"
                     /db_xref="CDD:238026"
     Region          319..489
                     /region_name="GuKc"
                     /note="Guanylate kinase homologues; smart00072"
                     /db_xref="CDD:214504"
     CDS             1..503
                     /gene="PALS1"
                     /gene_synonym="MPP5"
                     /coded_by="XM_047431696.1:3752..5263"
                     /db_xref="GeneID:64398"
                     /db_xref="HGNC:HGNC:18669"
                     /db_xref="MIM:606958"
ORIGIN      
        1 mnkasppfpl isnaqdlaqe vqtvlkpvhh kegqeltall ntphiqalll ahdkvaeqem
       61 qlepitderv yesigqygge tvkivrieka rdiplgatvr nemdsviisr ivkggaaeks
      121 gllhegdevl eingieirgk dvnevfdlls dmhgtltfvl ipsqqikppp aketvihvka
      181 hfdydpsddp yvpcrelgls fqkgdilhvi sqedpnwwqa yregdednqp laglvpgksf
      241 qqqreamkqt ieedkepeks gklwcakknk kkrkkvlyna nknddydnee iltyeemsly
      301 hqpanrkrpi iligpqncgq nelrqrlmnk ekdrfasavp httrsrrdqe vagrdyhfvs
      361 rqafeadiaa gkfiehgefe knlygtsids vrqvinsgki cllslrtqsl ktlrnsdlkp
      421 yiifiappsq erlrallake gknpkpeelr eiiektreme qnnghyfdta ivnsdldkay
      481 qellrlinkl dtepqwvpst wlr
//
LOCUS       XP_011535391             510 aa            linear   PRI 05-AUG-2025
DEFINITION  cadherin-24 isoform X1 [Homo sapiens].
ACCESSION   XP_011535391
VERSION     XP_011535391.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537089.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..510
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..510
                     /product="cadherin-24 isoform X1"
                     /calculated_mol_wt=55214
     Site            order(56..57,108,110,142,144..145)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          70..148
                     /region_name="CA"
                     /note="Cadherin repeats; smart00112"
                     /db_xref="CDD:214520"
     Region          154..255
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(161..162,216,218,251,253..254)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          264..368
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Region          379..>455
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     CDS             1..510
                     /gene="CDH24"
                     /gene_synonym="CDH11L"
                     /coded_by="XM_011537089.2:243..1775"
                     /db_xref="GeneID:64403"
                     /db_xref="HGNC:HGNC:14265"
                     /db_xref="MIM:618599"
ORIGIN      
        1 mwglvrllla wlggwgcmgr laaparawag srehpgpall rtrrswvwnq ffvieeyagp
       61 epvligklhs dvdrgegrtk ylltgegagt vfvideatgn ihvtksldre ekaqyvllaq
      121 avdrasnrpl eppsefiikv qdindnppif plgpyhatvp emsnvgtsvi qvtahdaddp
      181 sygnsaklvy tvldglpffs vdpqtgvvrt aipnmdretq eeflvviqak dmgghmggls
      241 gsttvtvtls dvndnppkfp qslyqfsvve tagpgtlvgr lraqdpdlgd nalmaysild
      301 gegseafsis tdlqgrdgll tvrkpldfes qrsysfrvea tntlidpayl rrgpfkdvas
      361 vrvavqdape ppaftqaayh ltvpenkapg tlvgqisaad ldspaspiry silphsdper
      421 cfsiqpeegt ihtaapldre arawhnltvl atelgwswgp ergwvpllva ewsapaappq
      481 rspvgsavgi pqgtihlqng fihliitttl
//
LOCUS       XP_047287653             472 aa            linear   PRI 05-AUG-2025
DEFINITION  cadherin-24 isoform X2 [Homo sapiens].
ACCESSION   XP_047287653
VERSION     XP_047287653.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431697.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..472
                     /product="cadherin-24 isoform X2"
                     /calculated_mol_wt=51237
     Site            order(56..57,108,110,142,144..145)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          70..148
                     /region_name="CA"
                     /note="Cadherin repeats; smart00112"
                     /db_xref="CDD:214520"
     Region          154..255
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(161..162,216,218,251,253..254)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          264..368
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Region          379..469
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     CDS             1..472
                     /gene="CDH24"
                     /gene_synonym="CDH11L"
                     /coded_by="XM_047431697.1:243..1661"
                     /db_xref="GeneID:64403"
                     /db_xref="HGNC:HGNC:14265"
                     /db_xref="MIM:618599"
ORIGIN      
        1 mwglvrllla wlggwgcmgr laaparawag srehpgpall rtrrswvwnq ffvieeyagp
       61 epvligklhs dvdrgegrtk ylltgegagt vfvideatgn ihvtksldre ekaqyvllaq
      121 avdrasnrpl eppsefiikv qdindnppif plgpyhatvp emsnvgtsvi qvtahdaddp
      181 sygnsaklvy tvldglpffs vdpqtgvvrt aipnmdretq eeflvviqak dmgghmggls
      241 gsttvtvtls dvndnppkfp qslyqfsvve tagpgtlvgr lraqdpdlgd nalmaysild
      301 gegseafsis tdlqgrdgll tvrkpldfes qrsysfrvea tntlidpayl rrgpfkdvas
      361 vrvavqdape ppaftqaayh ltvpenkapg tlvgqisaad ldspaspiry silphsdper
      421 cfsiqpeegt ihtaapldre arawhnltvl atelgtihlq ngfihliitt tl
//
LOCUS       XP_047287655            1091 aa            linear   PRI 05-AUG-2025
DEFINITION  pecanex-like protein 4 isoform X1 [Homo sapiens].
ACCESSION   XP_047287655
VERSION     XP_047287655.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431699.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1091
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1091
                     /product="pecanex-like protein 4 isoform X1"
                     /calculated_mol_wt=123409
     CDS             1..1091
                     /gene="PCNX4"
                     /gene_synonym="C14orf135; FBP2; PCNXL4"
                     /coded_by="XM_047431699.1:563..3838"
                     /db_xref="GeneID:64430"
                     /db_xref="HGNC:HGNC:20349"
ORIGIN      
        1 mspdvpllnd ykqdfflkrf pqtvlggprf klgycappyi yvnqiilflm pwvwggvgtl
       61 lyqlgilkdy ytaalsgglm lftafviqft slyaknkstt verilttdil aeedehefts
      121 ctgaetvkfl ipgkkyvant vfhsilagla cglgtwyllp nritllygst ggtallfffg
      181 wmtlciaeys livntateta tfqtqdtyei iplmrplyif ffvsvdlahr fvvnmpaleh
      241 mnqilhilfv flpflwalgt lpppdalllw ameqvlefgl ggssmsthlr llvmfimsag
      301 taiasyfips tvgvvlfmtg fgfllslnls dmghkigtks kdlpsgpekh fswkeclfyi
      361 iilvlallet sllhhfagfs qisksnsqai vgyglmilli ilwilreiqs vyiigifrnp
      421 fypkdvqtvt vffekqtrlm kigivrrill tlvspfamia flsldsslqg lhsvsvcigf
      481 trafrmvwqn tenalletvi vstvhlisst diwwnrsldt glrlllvgii rdrliqfisk
      541 lqfavtvllt swtekkqrrk ttatlcilni vfspfvlvii vfstllsspl lplftlpvfl
      601 vgfprpiqsw pgaagttacv cadtvyyyqm vprltavlqt amaagslgll lpgshylgrf
      661 qdrlmwimil ecgytycsin ikglelqets chtaearrvd evfedafeqe ytrvcslneh
      721 fgnvltpctv lpvklysdar nvlsgiidsh enlkefkgdl ikvlvwilvq ycskrpgmke
      781 nvhntenkgk aplmlpalnt lpppkspedi dslnsetfnd wsddnifdde ptikkvieek
      841 hqlkdlpgtn lfipgsvesq rvgdhstgtv pendlykavl lgypavdkgk qedmpyiplm
      901 efscshshlv clpaewrtsc mpsskmkems slfpedwyqf vlrqlecyhs eekasnvlee
      961 iakdkvlkdf yvhtvmtcyf slfgidnmap spghilrvyg gvlpwsvald wltekpelfq
     1021 lalkafrytl klmidkaslg piedfrelik yleeyerdwy iglvsdekwk eailqekpyl
     1081 fslgydsnmy l
//
LOCUS       XP_047287656             720 aa            linear   PRI 05-AUG-2025
DEFINITION  pecanex-like protein 4 isoform X2 [Homo sapiens].
ACCESSION   XP_047287656
VERSION     XP_047287656.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431700.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..720
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..720
                     /product="pecanex-like protein 4 isoform X2"
                     /calculated_mol_wt=80885
     CDS             1..720
                     /gene="PCNX4"
                     /gene_synonym="C14orf135; FBP2; PCNXL4"
                     /coded_by="XM_047431700.1:563..2725"
                     /db_xref="GeneID:64430"
                     /db_xref="HGNC:HGNC:20349"
ORIGIN      
        1 mspdvpllnd ykqdfflkrf pqtvlggprf klgycappyi yvnqiilflm pwvwggvgtl
       61 lyqlgilkdy ytaalsgglm lftafviqft slyaknkstt verilttdil aeedehefts
      121 ctgaetvkfl ipgkkyvant vfhsilagla cglgtwyllp nritllygst ggtallfffg
      181 wmtlciaeys livntateta tfqtqdtyei iplmrplyif ffvsvdlahr fvvnmpaleh
      241 mnqilhilfv flpflwalgt lpppdalllw ameqvlefgl ggssmsthlr llvmfimsag
      301 taiasyfips tvgvvlfmtg fgfllslnls dmghkigtks kdlpsgpekh fswkeclfyi
      361 iilvlallet sllhhfagfs qisksnsqai vgyglmilli ilwilreiqs vyiigifrnp
      421 fypkdvqtvt vffekqtrlm kigivrrill tlvspfamia flsldsslqg lhsvsvcigf
      481 trafrmvwqn tenalletvi vstvhlisst diwwnrsldt glrlllvgii rdrliqfisk
      541 lqfavtvllt swtekkqrrk ttatlcilni vfspfvlvii vfstllsspl lplftlpvfl
      601 vgfprpiqsw pgaagttacv cadtvyyyqm vprltavlqt amaagslgll lpgshylgrf
      661 qdrlmwimil ecgytycsin ikglelqets chtaearrvd evfedafeqe ytrvysetnd
//
LOCUS       XP_016877085             494 aa            linear   PRI 05-AUG-2025
DEFINITION  G-protein coupled receptor 135 isoform X1 [Homo sapiens].
ACCESSION   XP_016877085
VERSION     XP_016877085.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021596.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..494
                     /product="G-protein coupled receptor 135 isoform X1"
                     /calculated_mol_wt=51605
     Region          120..398
                     /region_name="7tm_GPCRs"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; cl28897"
                     /db_xref="CDD:475119"
     Region          139..161
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:410628"
     Region          185..207
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:410628"
     Region          228..244
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:410628"
     Region          275..298
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:410628"
     Region          330..352
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:410628"
     Region          366..391
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:410628"
     CDS             1..494
                     /gene="GPR135"
                     /gene_synonym="HUMNPIIY20"
                     /coded_by="XM_017021596.3:155..1639"
                     /db_xref="GeneID:64582"
                     /db_xref="HGNC:HGNC:19991"
                     /db_xref="MIM:607970"
ORIGIN      
        1 meepqpprpp asmallgsqh sgapsaagpp ggtssaataa vlsfstvata algnlsdasg
       61 ggtaaapggg glggsgaare agaavrrplg peaapllshg aavaaqalvl llifllsslg
      121 ncavmgvivk hrqlrtvtna filslslsdl ltallclpaa fldlftppgg sapaaaagpw
      181 rgfcaasrff sscfgivstl svalisldry caivrpprek igrrralqll agawltalgf
      241 slpwellgap relaaaqsfh gclyrtspdp aqlgaafsvg lvvacyllpf llmcfchyhi
      301 cktvrlsdvr vrpvntyarv lrffsevrta ttvlimivfv iccwgpycfl vllaaarqaq
      361 tmqapsllsv vavwltwang ainpviyair npnismllgr nreegyrtrn vdaflpsqgp
      421 glqarsrsrl rnryanrlga cnrmsssnpa sgvagdvamw arknpvvlfc regppepvta
      481 vtkqpkseag dtsl
//
LOCUS       XP_024305461             494 aa            linear   PRI 05-AUG-2025
DEFINITION  G-protein coupled receptor 135 isoform X1 [Homo sapiens].
ACCESSION   XP_024305461
VERSION     XP_024305461.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449693.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..494
                     /product="G-protein coupled receptor 135 isoform X1"
                     /calculated_mol_wt=51605
     Region          120..398
                     /region_name="7tm_GPCRs"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; cl28897"
                     /db_xref="CDD:475119"
     Region          139..161
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:410628"
     Region          185..207
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:410628"
     Region          228..244
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:410628"
     Region          275..298
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:410628"
     Region          330..352
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:410628"
     Region          366..391
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:410628"
     CDS             1..494
                     /gene="GPR135"
                     /gene_synonym="HUMNPIIY20"
                     /coded_by="XM_024449693.2:155..1639"
                     /db_xref="GeneID:64582"
                     /db_xref="HGNC:HGNC:19991"
                     /db_xref="MIM:607970"
ORIGIN      
        1 meepqpprpp asmallgsqh sgapsaagpp ggtssaataa vlsfstvata algnlsdasg
       61 ggtaaapggg glggsgaare agaavrrplg peaapllshg aavaaqalvl llifllsslg
      121 ncavmgvivk hrqlrtvtna filslslsdl ltallclpaa fldlftppgg sapaaaagpw
      181 rgfcaasrff sscfgivstl svalisldry caivrpprek igrrralqll agawltalgf
      241 slpwellgap relaaaqsfh gclyrtspdp aqlgaafsvg lvvacyllpf llmcfchyhi
      301 cktvrlsdvr vrpvntyarv lrffsevrta ttvlimivfv iccwgpycfl vllaaarqaq
      361 tmqapsllsv vavwltwang ainpviyair npnismllgr nreegyrtrn vdaflpsqgp
      421 glqarsrsrl rnryanrlga cnrmsssnpa sgvagdvamw arknpvvlfc regppepvta
      481 vtkqpkseag dtsl
//
LOCUS       XP_024305462             494 aa            linear   PRI 05-AUG-2025
DEFINITION  G-protein coupled receptor 135 isoform X1 [Homo sapiens].
ACCESSION   XP_024305462
VERSION     XP_024305462.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449694.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..494
                     /product="G-protein coupled receptor 135 isoform X1"
                     /calculated_mol_wt=51605
     Region          120..398
                     /region_name="7tm_GPCRs"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; cl28897"
                     /db_xref="CDD:475119"
     Region          139..161
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:410628"
     Region          185..207
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:410628"
     Region          228..244
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:410628"
     Region          275..298
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:410628"
     Region          330..352
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:410628"
     Region          366..391
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:410628"
     CDS             1..494
                     /gene="GPR135"
                     /gene_synonym="HUMNPIIY20"
                     /coded_by="XM_024449694.2:155..1639"
                     /db_xref="GeneID:64582"
                     /db_xref="HGNC:HGNC:19991"
                     /db_xref="MIM:607970"
ORIGIN      
        1 meepqpprpp asmallgsqh sgapsaagpp ggtssaataa vlsfstvata algnlsdasg
       61 ggtaaapggg glggsgaare agaavrrplg peaapllshg aavaaqalvl llifllsslg
      121 ncavmgvivk hrqlrtvtna filslslsdl ltallclpaa fldlftppgg sapaaaagpw
      181 rgfcaasrff sscfgivstl svalisldry caivrpprek igrrralqll agawltalgf
      241 slpwellgap relaaaqsfh gclyrtspdp aqlgaafsvg lvvacyllpf llmcfchyhi
      301 cktvrlsdvr vrpvntyarv lrffsevrta ttvlimivfv iccwgpycfl vllaaarqaq
      361 tmqapsllsv vavwltwang ainpviyair npnismllgr nreegyrtrn vdaflpsqgp
      421 glqarsrsrl rnryanrlga cnrmsssnpa sgvagdvamw arknpvvlfc regppepvta
      481 vtkqpkseag dtsl
//
LOCUS       XP_016877087             494 aa            linear   PRI 05-AUG-2025
DEFINITION  G-protein coupled receptor 135 isoform X1 [Homo sapiens].
ACCESSION   XP_016877087
VERSION     XP_016877087.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021598.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..494
                     /product="G-protein coupled receptor 135 isoform X1"
                     /calculated_mol_wt=51605
     Region          120..398
                     /region_name="7tm_GPCRs"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; cl28897"
                     /db_xref="CDD:475119"
     Region          139..161
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:410628"
     Region          185..207
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:410628"
     Region          228..244
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:410628"
     Region          275..298
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:410628"
     Region          330..352
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:410628"
     Region          366..391
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:410628"
     CDS             1..494
                     /gene="GPR135"
                     /gene_synonym="HUMNPIIY20"
                     /coded_by="XM_017021598.3:155..1639"
                     /db_xref="GeneID:64582"
                     /db_xref="HGNC:HGNC:19991"
                     /db_xref="MIM:607970"
ORIGIN      
        1 meepqpprpp asmallgsqh sgapsaagpp ggtssaataa vlsfstvata algnlsdasg
       61 ggtaaapggg glggsgaare agaavrrplg peaapllshg aavaaqalvl llifllsslg
      121 ncavmgvivk hrqlrtvtna filslslsdl ltallclpaa fldlftppgg sapaaaagpw
      181 rgfcaasrff sscfgivstl svalisldry caivrpprek igrrralqll agawltalgf
      241 slpwellgap relaaaqsfh gclyrtspdp aqlgaafsvg lvvacyllpf llmcfchyhi
      301 cktvrlsdvr vrpvntyarv lrffsevrta ttvlimivfv iccwgpycfl vllaaarqaq
      361 tmqapsllsv vavwltwang ainpviyair npnismllgr nreegyrtrn vdaflpsqgp
      421 glqarsrsrl rnryanrlga cnrmsssnpa sgvagdvamw arknpvvlfc regppepvta
      481 vtkqpkseag dtsl
//
LOCUS       XP_024305463             494 aa            linear   PRI 05-AUG-2025
DEFINITION  G-protein coupled receptor 135 isoform X1 [Homo sapiens].
ACCESSION   XP_024305463
VERSION     XP_024305463.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449695.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..494
                     /product="G-protein coupled receptor 135 isoform X1"
                     /calculated_mol_wt=51605
     Region          120..398
                     /region_name="7tm_GPCRs"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; cl28897"
                     /db_xref="CDD:475119"
     Region          139..161
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:410628"
     Region          185..207
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:410628"
     Region          228..244
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:410628"
     Region          275..298
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:410628"
     Region          330..352
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:410628"
     Region          366..391
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:410628"
     CDS             1..494
                     /gene="GPR135"
                     /gene_synonym="HUMNPIIY20"
                     /coded_by="XM_024449695.2:155..1639"
                     /db_xref="GeneID:64582"
                     /db_xref="HGNC:HGNC:19991"
                     /db_xref="MIM:607970"
ORIGIN      
        1 meepqpprpp asmallgsqh sgapsaagpp ggtssaataa vlsfstvata algnlsdasg
       61 ggtaaapggg glggsgaare agaavrrplg peaapllshg aavaaqalvl llifllsslg
      121 ncavmgvivk hrqlrtvtna filslslsdl ltallclpaa fldlftppgg sapaaaagpw
      181 rgfcaasrff sscfgivstl svalisldry caivrpprek igrrralqll agawltalgf
      241 slpwellgap relaaaqsfh gclyrtspdp aqlgaafsvg lvvacyllpf llmcfchyhi
      301 cktvrlsdvr vrpvntyarv lrffsevrta ttvlimivfv iccwgpycfl vllaaarqaq
      361 tmqapsllsv vavwltwang ainpviyair npnismllgr nreegyrtrn vdaflpsqgp
      421 glqarsrsrl rnryanrlga cnrmsssnpa sgvagdvamw arknpvvlfc regppepvta
      481 vtkqpkseag dtsl
//
LOCUS       XP_024305464             494 aa            linear   PRI 05-AUG-2025
DEFINITION  G-protein coupled receptor 135 isoform X1 [Homo sapiens].
ACCESSION   XP_024305464
VERSION     XP_024305464.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449696.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..494
                     /product="G-protein coupled receptor 135 isoform X1"
                     /calculated_mol_wt=51605
     Region          120..398
                     /region_name="7tm_GPCRs"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; cl28897"
                     /db_xref="CDD:475119"
     Region          139..161
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:410628"
     Region          185..207
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:410628"
     Region          228..244
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:410628"
     Region          275..298
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:410628"
     Region          330..352
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:410628"
     Region          366..391
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:410628"
     CDS             1..494
                     /gene="GPR135"
                     /gene_synonym="HUMNPIIY20"
                     /coded_by="XM_024449696.2:155..1639"
                     /db_xref="GeneID:64582"
                     /db_xref="HGNC:HGNC:19991"
                     /db_xref="MIM:607970"
ORIGIN      
        1 meepqpprpp asmallgsqh sgapsaagpp ggtssaataa vlsfstvata algnlsdasg
       61 ggtaaapggg glggsgaare agaavrrplg peaapllshg aavaaqalvl llifllsslg
      121 ncavmgvivk hrqlrtvtna filslslsdl ltallclpaa fldlftppgg sapaaaagpw
      181 rgfcaasrff sscfgivstl svalisldry caivrpprek igrrralqll agawltalgf
      241 slpwellgap relaaaqsfh gclyrtspdp aqlgaafsvg lvvacyllpf llmcfchyhi
      301 cktvrlsdvr vrpvntyarv lrffsevrta ttvlimivfv iccwgpycfl vllaaarqaq
      361 tmqapsllsv vavwltwang ainpviyair npnismllgr nreegyrtrn vdaflpsqgp
      421 glqarsrsrl rnryanrlga cnrmsssnpa sgvagdvamw arknpvvlfc regppepvta
      481 vtkqpkseag dtsl
//
LOCUS       XP_016877088             494 aa            linear   PRI 05-AUG-2025
DEFINITION  G-protein coupled receptor 135 isoform X1 [Homo sapiens].
ACCESSION   XP_016877088
VERSION     XP_016877088.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021599.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..494
                     /product="G-protein coupled receptor 135 isoform X1"
                     /calculated_mol_wt=51605
     Region          120..398
                     /region_name="7tm_GPCRs"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; cl28897"
                     /db_xref="CDD:475119"
     Region          139..161
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:410628"
     Region          185..207
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:410628"
     Region          228..244
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:410628"
     Region          275..298
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:410628"
     Region          330..352
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:410628"
     Region          366..391
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:410628"
     CDS             1..494
                     /gene="GPR135"
                     /gene_synonym="HUMNPIIY20"
                     /coded_by="XM_017021599.3:155..1639"
                     /db_xref="GeneID:64582"
                     /db_xref="HGNC:HGNC:19991"
                     /db_xref="MIM:607970"
ORIGIN      
        1 meepqpprpp asmallgsqh sgapsaagpp ggtssaataa vlsfstvata algnlsdasg
       61 ggtaaapggg glggsgaare agaavrrplg peaapllshg aavaaqalvl llifllsslg
      121 ncavmgvivk hrqlrtvtna filslslsdl ltallclpaa fldlftppgg sapaaaagpw
      181 rgfcaasrff sscfgivstl svalisldry caivrpprek igrrralqll agawltalgf
      241 slpwellgap relaaaqsfh gclyrtspdp aqlgaafsvg lvvacyllpf llmcfchyhi
      301 cktvrlsdvr vrpvntyarv lrffsevrta ttvlimivfv iccwgpycfl vllaaarqaq
      361 tmqapsllsv vavwltwang ainpviyair npnismllgr nreegyrtrn vdaflpsqgp
      421 glqarsrsrl rnryanrlga cnrmsssnpa sgvagdvamw arknpvvlfc regppepvta
      481 vtkqpkseag dtsl
//
LOCUS       XP_016877089             238 aa            linear   PRI 05-AUG-2025
DEFINITION  synapse differentiation-inducing gene protein 1-like isoform X1
            [Homo sapiens].
ACCESSION   XP_016877089
VERSION     XP_016877089.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021600.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..238
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..238
                     /product="synapse differentiation-inducing gene protein
                     1-like isoform X1"
                     /calculated_mol_wt=25665
     Region          157..217
                     /region_name="CD225"
                     /note="Interferon-induced transmembrane protein;
                     pfam04505"
                     /db_xref="CDD:461336"
     CDS             1..238
                     /gene="SYNDIG1L"
                     /gene_synonym="CAPUCIN; DSPC1; IFITMD4; SynDIG2; TMEM90A"
                     /coded_by="XM_017021600.2:5898..6614"
                     /db_xref="GeneID:646658"
                     /db_xref="HGNC:HGNC:32388"
                     /db_xref="MIM:609999"
ORIGIN      
        1 meslselqnp llprspahlh gpypypetpp swscqeklys yllggagpag ahqlldpgsl
       61 qlaveawyrp scllgrdkvk epragscets ftedrepqeg ppeqptgpgq aaenvtiqtv
      121 sygvqeelrd qeddqeeees datstesese dnfltlpprd hlgltlfsml ccfwplgiaa
      181 fyfsqgtska iskgdfrlas ttsrralfla tlaiavgagl yvavvvalaa ymsqnghg
//
LOCUS       XP_006720297             150 aa            linear   PRI 05-AUG-2025
DEFINITION  testis-expressed protein 22 isoform X1 [Homo sapiens].
ACCESSION   XP_006720297
VERSION     XP_006720297.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720234.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..150
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..150
                     /product="testis-expressed protein 22 isoform X1"
                     /calculated_mol_wt=16749
     CDS             1..150
                     /gene="TEX22"
                     /coded_by="XM_006720234.4:328..780"
                     /db_xref="GeneID:647310"
                     /db_xref="HGNC:HGNC:40026"
ORIGIN      
        1 mdsrklsprg kkleshlsqe hrrpplglia awgqpsiqss vqqglqtqdw vcepperrrp
       61 grrwsvside rrrlatlggr erpgaagtql hcrdvvqmva qlvsedvdkd vllphplrst
      121 estnafqafl arsapfwhna tfeasrspps
//
LOCUS       XP_005268069             184 aa            linear   PRI 05-AUG-2025
DEFINITION  glucosamine 6-phosphate N-acetyltransferase isoform X1 [Homo
            sapiens].
ACCESSION   XP_005268069
VERSION     XP_005268069.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005268012.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..184
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..184
                     /product="glucosamine 6-phosphate N-acetyltransferase
                     isoform X1"
                     /calculated_mol_wt=20618
     Region          36..174
                     /region_name="N-Acyltransferase superfamily: Various
                     enyzmes that characteristicly catalyze the transfer of an
                     acyl group to a substrate"
                     /note="NAT (N-Acyltransferase) is a large superfamily of
                     enzymes that mostly catalyze the transfer of an acyl group
                     to a substrate and are implicated in a variety of
                     functions, from bacterial antibiotic resistance to
                     circadian rhythms in mammals. Members...; cl17182"
                     /db_xref="CDD:473072"
     CDS             1..184
                     /gene="GNPNAT1"
                     /gene_synonym="GNA1; GNPNAT; Gpnat1; RHZDAN"
                     /coded_by="XM_005268012.4:234..788"
                     /db_xref="GeneID:64841"
                     /db_xref="HGNC:HGNC:19980"
                     /db_xref="MIM:616510"
ORIGIN      
        1 mkpdetpmfd psllkevdws qntatfspai spthpgeglv lrplctadln rgffkvlgql
       61 tetgvvspeq fmksfehmkk sgdyyvtvve dvtlgqivat atliiehkfi hscakrgrve
      121 dvvvsdecrg kqlgklllst ltllskklnc ykitleclpq nvgfykkfgy tvseenymcr
      181 rflk
//
LOCUS       XP_006720301             184 aa            linear   PRI 05-AUG-2025
DEFINITION  glucosamine 6-phosphate N-acetyltransferase isoform X1 [Homo
            sapiens].
ACCESSION   XP_006720301
VERSION     XP_006720301.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720238.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..184
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..184
                     /product="glucosamine 6-phosphate N-acetyltransferase
                     isoform X1"
                     /calculated_mol_wt=20618
     Region          36..174
                     /region_name="N-Acyltransferase superfamily: Various
                     enyzmes that characteristicly catalyze the transfer of an
                     acyl group to a substrate"
                     /note="NAT (N-Acyltransferase) is a large superfamily of
                     enzymes that mostly catalyze the transfer of an acyl group
                     to a substrate and are implicated in a variety of
                     functions, from bacterial antibiotic resistance to
                     circadian rhythms in mammals. Members...; cl17182"
                     /db_xref="CDD:473072"
     CDS             1..184
                     /gene="GNPNAT1"
                     /gene_synonym="GNA1; GNPNAT; Gpnat1; RHZDAN"
                     /coded_by="XM_006720238.4:665..1219"
                     /db_xref="GeneID:64841"
                     /db_xref="HGNC:HGNC:19980"
                     /db_xref="MIM:616510"
ORIGIN      
        1 mkpdetpmfd psllkevdws qntatfspai spthpgeglv lrplctadln rgffkvlgql
       61 tetgvvspeq fmksfehmkk sgdyyvtvve dvtlgqivat atliiehkfi hscakrgrve
      121 dvvvsdecrg kqlgklllst ltllskklnc ykitleclpq nvgfykkfgy tvseenymcr
      181 rflk
//
LOCUS       XP_047287661             184 aa            linear   PRI 05-AUG-2025
DEFINITION  glucosamine 6-phosphate N-acetyltransferase isoform X1 [Homo
            sapiens].
ACCESSION   XP_047287661
VERSION     XP_047287661.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431705.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..184
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..184
                     /product="glucosamine 6-phosphate N-acetyltransferase
                     isoform X1"
                     /calculated_mol_wt=20618
     Region          36..174
                     /region_name="N-Acyltransferase superfamily: Various
                     enyzmes that characteristicly catalyze the transfer of an
                     acyl group to a substrate"
                     /note="NAT (N-Acyltransferase) is a large superfamily of
                     enzymes that mostly catalyze the transfer of an acyl group
                     to a substrate and are implicated in a variety of
                     functions, from bacterial antibiotic resistance to
                     circadian rhythms in mammals. Members...; cl17182"
                     /db_xref="CDD:473072"
     CDS             1..184
                     /gene="GNPNAT1"
                     /gene_synonym="GNA1; GNPNAT; Gpnat1; RHZDAN"
                     /coded_by="XM_047431705.1:585..1139"
                     /db_xref="GeneID:64841"
                     /db_xref="HGNC:HGNC:19980"
                     /db_xref="MIM:616510"
ORIGIN      
        1 mkpdetpmfd psllkevdws qntatfspai spthpgeglv lrplctadln rgffkvlgql
       61 tetgvvspeq fmksfehmkk sgdyyvtvve dvtlgqivat atliiehkfi hscakrgrve
      121 dvvvsdecrg kqlgklllst ltllskklnc ykitleclpq nvgfykkfgy tvseenymcr
      181 rflk
//
LOCUS       XP_047287663             848 aa            linear   PRI 05-AUG-2025
DEFINITION  B-cell lymphoma/leukemia 11B isoform X1 [Homo sapiens].
ACCESSION   XP_047287663
VERSION     XP_047287663.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431707.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..848
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..848
                     /product="B-cell lymphoma/leukemia 11B isoform X1"
                     /calculated_mol_wt=90283
     Region          382..403
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          383..403
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275370"
     Site            order(388,390,392,394..395,398..399,402,416,418..420,
                     422..423,427,430)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275370"
     Region          395..420
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          411..431
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275370"
     Region          751..772
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          752..772
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(757,759,761,763..764,767..768,771,785,787,791..792,
                     795..796,799,815,817,819,821..822,825..826)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          764..789
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          780..800
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          810..828
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..848
                     /gene="BCL11B"
                     /gene_synonym="ATL1; ATL1-alpha; ATL1-beta; ATL1-delta;
                     ATL1-gamma; CTIP-2; CTIP2; hRIT1-alpha; IDDFSTA; IMD49;
                     RIT1; SMARCM2; ZNF856B"
                     /coded_by="XM_047431707.1:118..2664"
                     /db_xref="GeneID:64919"
                     /db_xref="HGNC:HGNC:13222"
                     /db_xref="MIM:606558"
ORIGIN      
        1 mvggpdpdll tcgqcqmnfp lgdilvfieh krkqcggslg acydkaldkd spppssrsel
       61 rkvsepveig iqvtpdeddh llsptkgicp kqeniagpcr paqlpavapi aasshphssv
      121 itsplralga lppclplpcc sarpvsgdgt qgegqteapf gcqcqlsgkd epssyicttc
      181 kqpfnsawfl lqhaqnthgf riylepgpas ssltprltip pplgpeavaq splmnflgds
      241 npfnllrmtg pilrdhpgfg egrlpgtppl fsppprhhld phrlsaeemg lvaqhpsafd
      301 rvmrlnpmai dspamdfsrr lrelagnsst pppvspgrgn pmhrllnpfq pspkspflst
      361 pplppmppgg tpppqppaks kscefcgktf kfqsnlivhr rshtgekpyk cqlcdhacsq
      421 asklkrhmkt hmhkagslag rsddglsaas spepgtsela geglkaadgd frhhesdpsl
      481 ghepeeedee eeeeeeelll enesrpessf smdselsrnr enggggvpgv pgagggaaka
      541 ladekalvlg kvmenvglga lpqygellad kqkrgaflkr aagggdagdd ddaggcgdag
      601 aggavngrgg gfapgtepfp glfprkpapl pspglnsaak rikvekdlel ppaalipsen
      661 vysqwlvgya asrhfmkdpf lgftdarqsp fatssehsse ngslrfstpp gdlldgglsg
      721 rsgtasggst phlggpgpgr psskegrrsd tceycgkvfk ncsnltvhrr shtgerpykc
      781 elcnyacaqs skltrhmkth gqigkevyrc dicqmpfsvy stlekhmkkw hgehlltndv
      841 kieqaers
//
LOCUS       XP_047287664             771 aa            linear   PRI 05-AUG-2025
DEFINITION  B-cell lymphoma/leukemia 11B isoform X2 [Homo sapiens].
ACCESSION   XP_047287664
VERSION     XP_047287664.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431708.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..771
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..771
                     /product="B-cell lymphoma/leukemia 11B isoform X2"
                     /calculated_mol_wt=82285
     Region          305..326
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          306..326
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275370"
     Site            order(311,313,315,317..318,321..322,325,339,341..343,
                     345..346,350,353)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275370"
     Region          318..343
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          334..354
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275370"
     Region          674..695
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          675..695
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(680,682,684,686..687,690..691,694,708,710,714..715,
                     718..719,722,738,740,742,744..745,748..749)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          687..712
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          703..723
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          733..751
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..771
                     /gene="BCL11B"
                     /gene_synonym="ATL1; ATL1-alpha; ATL1-beta; ATL1-delta;
                     ATL1-gamma; CTIP-2; CTIP2; hRIT1-alpha; IDDFSTA; IMD49;
                     RIT1; SMARCM2; ZNF856B"
                     /coded_by="XM_047431708.1:980..3295"
                     /db_xref="GeneID:64919"
                     /db_xref="HGNC:HGNC:13222"
                     /db_xref="MIM:606558"
ORIGIN      
        1 msrrkqgnpq hlsqrelitr pcrpaqlpav apiaasshph ssvitsplra lgalppclpl
       61 pccsarpvsg dgtqgegqte apfgcqcqls gkdepssyic ttckqpfnsa wfllqhaqnt
      121 hgfriylepg passsltprl tippplgpea vaqsplmnfl gdsnpfnllr mtgpilrdhp
      181 gfgegrlpgt pplfsppprh hldphrlsae emglvaqhps afdrvmrlnp maidspamdf
      241 srrlrelagn sstpppvspg rgnpmhrlln pfqpspkspf lstpplppmp pggtpppqpp
      301 akskscefcg ktfkfqsnli vhrrshtgek pykcqlcdha csqasklkrh mkthmhkags
      361 lagrsddgls aasspepgts elageglkaa dgdfrhhesd pslghepeee deeeeeeeee
      421 lllenesrpe ssfsmdsels rnrenggggv pgvpgaggga akaladekal vlgkvmenvg
      481 lgalpqygel ladkqkrgaf lkraagggda gddddaggcg dagaggavng rgggfapgte
      541 pfpglfprkp aplpspglns aakrikvekd lelppaalip senvysqwlv gyaasrhfmk
      601 dpflgftdar qspfatsseh ssengslrfs tppgdlldgg lsgrsgtasg gstphlggpg
      661 pgrpsskegr rsdtceycgk vfkncsnltv hrrshtgerp ykcelcnyac aqsskltrhm
      721 kthgqigkev yrcdicqmpf svystlekhm kkwhgehllt ndvkieqaer s
//
LOCUS       XP_016877095             927 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium/calcium exchanger 3 isoform X1 [Homo sapiens].
ACCESSION   XP_016877095
VERSION     XP_016877095.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021606.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..927
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..927
                     /product="sodium/calcium exchanger 3 isoform X1"
                     /calculated_mol_wt=102879
     Region          1..927
                     /region_name="caca"
                     /note="sodium/calcium exchanger 1; TIGR00845"
                     /db_xref="CDD:273296"
     CDS             1..927
                     /gene="SLC8A3"
                     /gene_synonym="NCX3"
                     /coded_by="XM_017021606.2:160..2943"
                     /db_xref="GeneID:6547"
                     /db_xref="HGNC:HGNC:11070"
                     /db_xref="MIM:607991"
ORIGIN      
        1 mawlrlqplt saflhfglvt fvlflnglra eaggsgdvps tgqnnescsg ssdckegvil
       61 piwypenpsl gdkiarvivy fvaliymflg vsiiadrfma sievitsqer evtikkpnge
      121 tstttirvwn etvsnltlma lgssapeill slievcghgf iagdlgpsti vgsaafnmfi
      181 iigicvyvip dgetrkikhl rvffitaaws ifayiwlymi lavfspgvvq vweglltlff
      241 fpvcvllawv adkrllfyky mhkkyrtdkh rgiiietegd hpkgiemdgk mmnshfldgn
      301 lvplegkevd esrremiril kdlkqkhpek dldqlveman yyalshqqks rafyriqatr
      361 mmtgagnilk khaaeqakka ssmsevhtde pedfiskvff dpcsyqclen cgavlltvvr
      421 kggdmsktmy vdyktedgsa nagadyefte gtvvlkpget qkefsvgiid ddifeedehf
      481 fvrlsnvrie eeqpeegmpp aifnslplpr avlaspcvat vtildddhag iftfecdtih
      541 vsesigvmev kvlrtsgarg tvivpfrtve gtakgggedf edtygelefk ndetvktirv
      601 kivdeeeyer qenffialge pkwmergisa lllspdvtdr kltmeeeeak riaemgkpvl
      661 gehpklevii eesyefkttv dklikktnla lvvgthswrd qfmeaitvsa agdededesg
      721 eerlpscfdy vmhfltvfwk vlfacvppte ychgwacfav siliigmlta iigdlashfg
      781 ctiglkdsvt avvfvafgts vpdtfaskaa alqdvyadas ignvtgsnav nvflgiglaw
      841 svaaiywalq gqefhvsagt lafsvtlfti fafvcisvll yrrrphlgge lggprgckla
      901 ttwlfvslwl lyilfatlea ycyikgf
//
LOCUS       XP_016877096             926 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium/calcium exchanger 3 isoform X2 [Homo sapiens].
ACCESSION   XP_016877096
VERSION     XP_016877096.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021607.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..926
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..926
                     /product="sodium/calcium exchanger 3 isoform X2"
                     /calculated_mol_wt=102808
     Region          1..926
                     /region_name="caca"
                     /note="sodium/calcium exchanger 1; TIGR00845"
                     /db_xref="CDD:273296"
     CDS             1..926
                     /gene="SLC8A3"
                     /gene_synonym="NCX3"
                     /coded_by="XM_017021607.2:636..3416"
                     /db_xref="GeneID:6547"
                     /db_xref="HGNC:HGNC:11070"
                     /db_xref="MIM:607991"
ORIGIN      
        1 mawlrlqplt saflhfglvt fvlflnglra eaggsgdvps tgqnnescsg ssdckegvil
       61 piwypenpsl gdkiarvivy fvaliymflg vsiiadrfma sievitsqer evtikkpnge
      121 tstttirvwn etvsnltlma lgssapeill slievcghgf iagdlgpsti vgsaafnmfi
      181 iigicvyvip dgetrkikhl rvffitaaws ifayiwlymi lavfspgvvq vweglltlff
      241 fpvcvllawv adkrllfyky mhkkyrtdkh rgiiietegd hpkgiemdgk mmnshfldgn
      301 lvplegkevd esrremiril kdlkqkhpek dldqlveman yyalshqqks rafyriqatr
      361 mmtgagnilk khaaeqakka ssmsevhtde pedfiskvff dpcsyqclen cgavlltvvr
      421 kggdmsktmy vdyktedgsa nagadyefte gtvvlkpget qkefsvgiid ddifeedehf
      481 fvrlsnvrie eeqpeegmpp aifnslplpr avlaspcvat vtildddhag iftfecdtih
      541 vsesigvmev kvlrtsgarg tvivpfrtve gtakgggedf edtygelefk ndetvktirv
      601 kivdeeeyer qenffialge pkwmergisa lllspdvtdr kltmeeeeak riaemgkpvl
      661 gehpklevii eesyefkttv dklikktnla lvvgthswrd qfmeaitvsa gdededesge
      721 erlpscfdyv mhfltvfwkv lfacvpptey chgwacfavs iliigmltai igdlashfgc
      781 tiglkdsvta vvfvafgtsv pdtfaskaaa lqdvyadasi gnvtgsnavn vflgiglaws
      841 vaaiywalqg qefhvsagtl afsvtlftif afvcisvlly rrrphlggel ggprgcklat
      901 twlfvslwll yilfatleay cyikgf
//
LOCUS       XP_047287667             920 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium/calcium exchanger 3 isoform X4 [Homo sapiens].
ACCESSION   XP_047287667
VERSION     XP_047287667.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431711.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..920
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..920
                     /product="sodium/calcium exchanger 3 isoform X4"
                     /calculated_mol_wt=102213
     Region          1..920
                     /region_name="caca"
                     /note="sodium/calcium exchanger 1; TIGR00845"
                     /db_xref="CDD:273296"
     CDS             1..920
                     /gene="SLC8A3"
                     /gene_synonym="NCX3"
                     /coded_by="XM_047431711.1:160..2922"
                     /db_xref="GeneID:6547"
                     /db_xref="HGNC:HGNC:11070"
                     /db_xref="MIM:607991"
ORIGIN      
        1 mawlrlqplt saflhfglvt fvlflnglra eaggsgdvps tgqnnescsg ssdckegvil
       61 piwypenpsl gdkiarvivy fvaliymflg vsiiadrfma sievitsqer evtikkpnge
      121 tstttirvwn etvsnltlma lgssapeill slievcghgf iagdlgpsti vgsaafnmfi
      181 iigicvyvip dgetrkikhl rvffitaaws ifayiwlymi lavfspgvvq vweglltlff
      241 fpvcvllawv adkrllfyky mhkkyrtdkh rgiiietegd hpkgiemdgk mmnshfldgn
      301 lvplegkevd esrremiril kdlkqkhpek dldqlveman yyalshqqks rafyriqatr
      361 mmtgagnilk khaaeqakka ssmsevhtde pedfiskvff dpcsyqclen cgavlltvvr
      421 kggdmsktmy vdyktedgsa nagadyefte gtvvlkpget qkefsvgiid ddifeedehf
      481 fvrlsnvrie eeqpeegmpp aifnslplpr avlaspcvat vtildddhag iftfecdtih
      541 vsesigvmev kvlrtsgarg tvivpfrtve gtakgggedf edtygelefk ndetvktirv
      601 kivdeeeyer qenffialge pkwmergisd vtdrkltmee eeakriaemg kpvlgehpkl
      661 eviieesyef kttvdklikk tnlalvvgth swrdqfmeai tvsagdeded esgeerlpsc
      721 fdyvmhfltv fwkvlfacvp pteychgwac favsiliigm ltaiigdlas hfgctiglkd
      781 svtavvfvaf gtsvpdtfas kaaalqdvya dasignvtgs navnvflgig lawsvaaiyw
      841 alqgqefhvs agtlafsvtl ftifafvcis vllyrrrphl ggelggprgc klattwlfvs
      901 lwllyilfat leaycyikgf
//
LOCUS       XP_016877099             617 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium/calcium exchanger 3 isoform X5 [Homo sapiens].
ACCESSION   XP_016877099
VERSION     XP_016877099.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021610.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..617
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..617
                     /product="sodium/calcium exchanger 3 isoform X5"
                     /calculated_mol_wt=68304
     Region          1..>595
                     /region_name="caca"
                     /note="sodium/calcium exchanger 1; TIGR00845"
                     /db_xref="CDD:273296"
     CDS             1..617
                     /gene="SLC8A3"
                     /gene_synonym="NCX3"
                     /coded_by="XM_017021610.2:636..2489"
                     /db_xref="GeneID:6547"
                     /db_xref="HGNC:HGNC:11070"
                     /db_xref="MIM:607991"
ORIGIN      
        1 mawlrlqplt saflhfglvt fvlflnglra eaggsgdvps tgqnnescsg ssdckegvil
       61 piwypenpsl gdkiarvivy fvaliymflg vsiiadrfma sievitsqer evtikkpnge
      121 tstttirvwn etvsnltlma lgssapeill slievcghgf iagdlgpsti vgsaafnmfi
      181 iigicvyvip dgetrkikhl rvffitaaws ifayiwlymi lavfspgvvq vweglltlff
      241 fpvcvllawv adkrllfyky mhkkyrtdkh rgiiietegd hpkgiemdgk mmnshfldgn
      301 lvplegkevd esrremiril kdlkqkhpek dldqlveman yyalshqqks rafyriqatr
      361 mmtgagnilk khaaeqakka ssmsevhtde pedfiskvff dpcsyqclen cgavlltvvr
      421 kggdmsktmy vdyktedgsa nagadyefte gtvvlkpget qkefsvgiid ddifeedehf
      481 fvrlsnvrie eeqpeegmpp aifnslplpr avlaspcvat vtildddhag iftfecdtih
      541 vsesigvmev kvlrtsgarg tvivpfrtve gtakgggedf edtygelefk ndetvyagsa
      601 dttgqvllpn sssvfsl
//
LOCUS       XP_016877100             311 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium/calcium exchanger 3 isoform X6 [Homo sapiens].
ACCESSION   XP_016877100
VERSION     XP_016877100.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021611.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..311
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..311
                     /product="sodium/calcium exchanger 3 isoform X6"
                     /calculated_mol_wt=34075
     Region          <4..311
                     /region_name="caca"
                     /note="sodium/calcium exchanger 1; TIGR00845"
                     /db_xref="CDD:273296"
     CDS             1..311
                     /gene="SLC8A3"
                     /gene_synonym="NCX3"
                     /coded_by="XM_017021611.2:574..1509"
                     /db_xref="GeneID:6547"
                     /db_xref="HGNC:HGNC:11070"
                     /db_xref="MIM:607991"
ORIGIN      
        1 mmgprmvdms fqkalllspd vtdrkltmee eeakriaemg kpvlgehpkl eviieesyef
       61 kttvdklikk tnlalvvgth swrdqfmeai tvsaagdede desgeerlps cfdyvmhflt
      121 vfwkvlfacv ppteychgwa cfavsiliig mltaiigdla shfgctiglk dsvtavvfva
      181 fgtsvpdtfa skaaalqdvy adasignvtg snavnvflgi glawsvaaiy walqgqefhv
      241 sagtlafsvt lftifafvci svllyrrrph lggelggprg cklattwlfv slwllyilfa
      301 tleaycyikg f
//
LOCUS       XP_006720303             304 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium/calcium exchanger 3 isoform X7 [Homo sapiens].
ACCESSION   XP_006720303
VERSION     XP_006720303.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720240.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..304
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..304
                     /product="sodium/calcium exchanger 3 isoform X7"
                     /calculated_mol_wt=33209
     Region          <1..304
                     /region_name="caca"
                     /note="sodium/calcium exchanger 1; TIGR00845"
                     /db_xref="CDD:273296"
     CDS             1..304
                     /gene="SLC8A3"
                     /gene_synonym="NCX3"
                     /coded_by="XM_006720240.4:339..1253"
                     /db_xref="GeneID:6547"
                     /db_xref="HGNC:HGNC:11070"
                     /db_xref="MIM:607991"
ORIGIN      
        1 mergisalll spdvtdrklt meeeeakria emgkpvlgeh pkleviiees yefkttvdkl
       61 ikktnlalvv gthswrdqfm eaitvsaagd ededesgeer lpscfdyvmh fltvfwkvlf
      121 acvppteych gwacfavsil iigmltaiig dlashfgcti glkdsvtavv fvafgtsvpd
      181 tfaskaaalq dvyadasign vtgsnavnvf lgiglawsva aiywalqgqe fhvsagtlaf
      241 svtlftifaf vcisvllyrr rphlggelgg prgcklattw lfvslwllyi lfatleaycy
      301 ikgf
//
LOCUS       XP_047287669            1397 aa            linear   PRI 05-AUG-2025
DEFINITION  son of sevenless homolog 2 isoform X1 [Homo sapiens].
ACCESSION   XP_047287669
VERSION     XP_047287669.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431713.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1397
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1397
                     /product="son of sevenless homolog 2 isoform X1"
                     /calculated_mol_wt=159652
     Region          18..142
                     /region_name="HFD_SOS1_rpt1"
                     /note="first histone-fold domain found in son of sevenless
                     homolog 1 (SOS-1) and similar proteins; cd22914"
                     /db_xref="CDD:467039"
     Region          151..219
                     /region_name="HFD_SOS1_rpt2"
                     /note="second histone-fold domain found in son of
                     sevenless homolog 1 (SOS-1) and similar proteins; cd22915"
                     /db_xref="CDD:467040"
     Region          264..451
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
                     (DH) domain. It appears that PH domains invariably occur
                     C-terminal to RhoGEF/DH domains; cd00160"
                     /db_xref="CDD:238091"
     Site            order(270,274,375,403..404,407..408,410..411,414..415,
                     418..419,422,447,451)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          502..608
                     /region_name="PH_SOS"
                     /note="Son of Sevenless (SOS) Pleckstrin homology (PH)
                     domain; cd01261"
                     /db_xref="CDD:269963"
     Region          660..804
                     /region_name="RasGEFN"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     GTPases; N-terminal motif; smart00229"
                     /db_xref="CDD:214571"
     Site            order(679,746,750..751,754,757..758,791..792,795,802)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:100121"
     Region          839..1078
                     /region_name="RasGEF"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     small GTPases. Small GTP-binding proteins of the Ras
                     superfamily function as molecular switches in fundamental
                     events such as signal transduction, cytoskeleton dynamics
                     and intracellular trafficking; cd00155"
                     /db_xref="CDD:238087"
     Site            order(872..874,884..885,887..889,891..892,895..896,899,
                     932,935..936,938..940,942..945,947..948,968,974..976,979,
                     992..994,997..999,1001..1003,1005..1008,1026,1030,1070,
                     1073..1074)
                     /site_type="other"
                     /note="Ras interaction site [polypeptide binding]"
                     /db_xref="CDD:238087"
     CDS             1..1397
                     /gene="SOS2"
                     /gene_synonym="NS9; SOS-2"
                     /coded_by="XM_047431713.1:296..4489"
                     /db_xref="GeneID:6655"
                     /db_xref="HGNC:HGNC:11188"
                     /db_xref="MIM:601247"
ORIGIN      
        1 mqqapqpyef fseenspkwr gllvsalrkm esrffarlgc sgailahcnl hlsgssdspa
       61 sasrvagttg vchhaqvqeq vhptlsanee slyyieelif qllnklcmaq prtvqdveer
      121 vqktfphpid kwaiadaqsa iekrkrrnpl llpvdkihps lkevlgykvd yhvslyivav
      181 leyisadilk lagnyvfnir hyeisqqdik vsmcadkplv ttfysasmsl fqiphvlmdm
      241 fdqddiglvs lcedepsssg elnyydlvrt eiaeerqylr elnmiikvfr eaflsdrklf
      301 kpsdiekifs nisdiheltv kllgliedtv emtdessphp lagscfedla eeqafdpyet
      361 lsqdilspef hehfnklmar pavalhfqsi adgfkeavry vlprlmlvpv yhcwhyfell
      421 kqlkacseeq edreclnqai talmnlqgsm driykqyspr rrpgdpvcpf yshqlrskhl
      481 aikkmneiqk nidgwegkdi gqccnefime gpltrigakh erhiflfdgl misckpnhgq
      541 trlpgyssae yrlkekfvmr kiqicdkedt cehkhafelv skdensiifa aksaeeknnw
      601 maalislhyr stldrmldsv llkeeneqpl rlpspevyrf vvkdseeniv fednlqsrsg
      661 ipiikggtvv klierltyhm yadpnfvrtf lttyrsfckp qellsllier feipepeptd
      721 adklaiekge qpisadlkrf rkeyvqpvql rilnvfrhwv ehhfydferd lellerlesf
      781 issvrgkamk kwvesiakii rrkkqaqang vshnitfesp pppiewhisk pgqfetfdlm
      841 tlhpieiarq ltllesdlyr kvqpselvgs vwtkedkein spnllkmirh ttnltlwfek
      901 civeaenfee rvavlsriie ilqvfqdlnn fngvleivsa vnsvsvyrld htfealqerk
      961 rkildeavel sqdhfkkylv klksinppcv pffgiyltni lkteegnndf lkkkgkdlin
     1021 fskrrkvaei tgeiqqyqnq pyclriepdm rrffenlnpm gsasekeftd ylfnksleie
     1081 prnckqpprf prkstfslks pgirpntgrh gstsgtlrgh ptplerepck isfsriaete
     1141 lestvsapts pntpstppvs assdlsvfld vdlnsscgsn sifapvllph sksffsscgs
     1201 lhklseepli ppplpprkkf dhdasnskgn mksdddppai pprqppppkv kprvpvptga
     1261 fdgplhsppp ppprdplpdt pppvplrppe hfincpfnlq ppplghlhrd sdwlrdistc
     1321 pnspstppst psprvprrcy vlsssqnnla hppappvppr qnssphlpkl ppktykrels
     1381 hpplyrlpll enaetpq
//
LOCUS       XP_047287670            1379 aa            linear   PRI 05-AUG-2025
DEFINITION  son of sevenless homolog 2 isoform X2 [Homo sapiens].
ACCESSION   XP_047287670
VERSION     XP_047287670.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431714.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1379
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1379
                     /product="son of sevenless homolog 2 isoform X2"
                     /calculated_mol_wt=157630
     Region          18..142
                     /region_name="HFD_SOS1_rpt1"
                     /note="first histone-fold domain found in son of sevenless
                     homolog 1 (SOS-1) and similar proteins; cd22914"
                     /db_xref="CDD:467039"
     Region          151..223
                     /region_name="HFD_SOS1_rpt2"
                     /note="second histone-fold domain found in son of
                     sevenless homolog 1 (SOS-1) and similar proteins; cd22915"
                     /db_xref="CDD:467040"
     Region          246..433
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
                     (DH) domain. It appears that PH domains invariably occur
                     C-terminal to RhoGEF/DH domains; cd00160"
                     /db_xref="CDD:238091"
     Site            order(252,256,357,385..386,389..390,392..393,396..397,
                     400..401,404,429,433)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          484..590
                     /region_name="PH_SOS"
                     /note="Son of Sevenless (SOS) Pleckstrin homology (PH)
                     domain; cd01261"
                     /db_xref="CDD:269963"
     Region          642..786
                     /region_name="RasGEFN"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     GTPases; N-terminal motif; smart00229"
                     /db_xref="CDD:214571"
     Site            order(661,728,732..733,736,739..740,773..774,777,784)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:100121"
     Region          821..1060
                     /region_name="RasGEF"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     small GTPases. Small GTP-binding proteins of the Ras
                     superfamily function as molecular switches in fundamental
                     events such as signal transduction, cytoskeleton dynamics
                     and intracellular trafficking; cd00155"
                     /db_xref="CDD:238087"
     Site            order(854..856,866..867,869..871,873..874,877..878,881,
                     914,917..918,920..922,924..927,929..930,950,956..958,961,
                     974..976,979..981,983..985,987..990,1008,1012,1052,
                     1055..1056)
                     /site_type="other"
                     /note="Ras interaction site [polypeptide binding]"
                     /db_xref="CDD:238087"
     CDS             1..1379
                     /gene="SOS2"
                     /gene_synonym="NS9; SOS-2"
                     /coded_by="XM_047431714.1:296..4435"
                     /db_xref="GeneID:6655"
                     /db_xref="HGNC:HGNC:11188"
                     /db_xref="MIM:601247"
ORIGIN      
        1 mqqapqpyef fseenspkwr gllvsalrkm esrffarlgc sgailahcnl hlsgssdspa
       61 sasrvagttg vchhaqvqeq vhptlsanee slyyieelif qllnklcmaq prtvqdveer
      121 vqktfphpid kwaiadaqsa iekrkrrnpl llpvdkihps lkevlgykvd yhvslyivav
      181 leyisadilk lagnyvfnir hyeisqqdik vsmcadkvlm dmfdqddigl vslcedepss
      241 sgelnyydlv rteiaeerqy lrelnmiikv freaflsdrk lfkpsdieki fsnisdihel
      301 tvkllglied tvemtdessp hplagscfed laeeqafdpy etlsqdilsp efhehfnklm
      361 arpavalhfq siadgfkeav ryvlprlmlv pvyhcwhyfe llkqlkacse eqedreclnq
      421 aitalmnlqg smdriykqys prrrpgdpvc pfyshqlrsk hlaikkmnei qknidgwegk
      481 digqccnefi megpltriga kherhiflfd glmisckpnh gqtrlpgyss aeyrlkekfv
      541 mrkiqicdke dtcehkhafe lvskdensii faaksaeekn nwmaalislh yrstldrmld
      601 svllkeeneq plrlpspevy rfvvkdseen ivfednlqsr sgipiikggt vvklierlty
      661 hmyadpnfvr tflttyrsfc kpqellslli erfeipepep tdadklaiek geqpisadlk
      721 rfrkeyvqpv qlrilnvfrh wvehhfydfe rdlellerle sfissvrgka mkkwvesiak
      781 iirrkkqaqa ngvshnitfe sppppiewhi skpgqfetfd lmtlhpieia rqltllesdl
      841 yrkvqpselv gsvwtkedke inspnllkmi rhttnltlwf ekciveaenf eervavlsri
      901 ieilqvfqdl nnfngvleiv savnsvsvyr ldhtfealqe rkrkildeav elsqdhfkky
      961 lvklksinpp cvpffgiylt nilkteegnn dflkkkgkdl infskrrkva eitgeiqqyq
     1021 nqpyclriep dmrrffenln pmgsasekef tdylfnksle ieprnckqpp rfprkstfsl
     1081 kspgirpntg rhgstsgtlr ghptplerep ckisfsriae telestvsap tspntpstpp
     1141 vsassdlsvf ldvdlnsscg snsifapvll phsksffssc gslhklseep lippplpprk
     1201 kfdhdasnsk gnmksdddpp aipprqpppp kvkprvpvpt gafdgplhsp ppppprdplp
     1261 dtpppvplrp pehfincpfn lqppplghlh rdsdwlrdis tcpnspstpp stpsprvprr
     1321 cyvlsssqnn lahppappvp prqnssphlp klppktykre lshpplyrlp llenaetpq
//
LOCUS       XP_047287671            1364 aa            linear   PRI 05-AUG-2025
DEFINITION  son of sevenless homolog 2 isoform X3 [Homo sapiens].
ACCESSION   XP_047287671
VERSION     XP_047287671.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431715.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1364
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1364
                     /product="son of sevenless homolog 2 isoform X3"
                     /calculated_mol_wt=155675
     Region          18..142
                     /region_name="HFD_SOS1_rpt1"
                     /note="first histone-fold domain found in son of sevenless
                     homolog 1 (SOS-1) and similar proteins; cd22914"
                     /db_xref="CDD:467039"
     Region          151..219
                     /region_name="HFD_SOS1_rpt2"
                     /note="second histone-fold domain found in son of
                     sevenless homolog 1 (SOS-1) and similar proteins; cd22915"
                     /db_xref="CDD:467040"
     Region          272..419
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; smart00325"
                     /db_xref="CDD:214619"
     Region          469..575
                     /region_name="PH_SOS"
                     /note="Son of Sevenless (SOS) Pleckstrin homology (PH)
                     domain; cd01261"
                     /db_xref="CDD:269963"
     Region          627..771
                     /region_name="RasGEFN"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     GTPases; N-terminal motif; smart00229"
                     /db_xref="CDD:214571"
     Site            order(646,713,717..718,721,724..725,758..759,762,769)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:100121"
     Region          806..1045
                     /region_name="RasGEF"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     small GTPases. Small GTP-binding proteins of the Ras
                     superfamily function as molecular switches in fundamental
                     events such as signal transduction, cytoskeleton dynamics
                     and intracellular trafficking; cd00155"
                     /db_xref="CDD:238087"
     Site            order(839..841,851..852,854..856,858..859,862..863,866,
                     899,902..903,905..907,909..912,914..915,935,941..943,946,
                     959..961,964..966,968..970,972..975,993,997,1037,
                     1040..1041)
                     /site_type="other"
                     /note="Ras interaction site [polypeptide binding]"
                     /db_xref="CDD:238087"
     CDS             1..1364
                     /gene="SOS2"
                     /gene_synonym="NS9; SOS-2"
                     /coded_by="XM_047431715.1:296..4390"
                     /db_xref="GeneID:6655"
                     /db_xref="HGNC:HGNC:11188"
                     /db_xref="MIM:601247"
ORIGIN      
        1 mqqapqpyef fseenspkwr gllvsalrkm esrffarlgc sgailahcnl hlsgssdspa
       61 sasrvagttg vchhaqvqeq vhptlsanee slyyieelif qllnklcmaq prtvqdveer
      121 vqktfphpid kwaiadaqsa iekrkrrnpl llpvdkihps lkevlgykvd yhvslyivav
      181 leyisadilk lagnyvfnir hyeisqqdik vsmcadkplv ttfysasmsl fqiphvlmdm
      241 fdqddiglvs lcedepsssg elnyydlvrt eiaeerqylr elnmiikvfr eaflsdrklf
      301 kpsdiekifs nisdiheltv kllgliedtv emtdessphp lagscfedla eeqafdpyet
      361 lsqdilspef hehfnklmar pavalhfqql kacseeqedr eclnqaital mnlqgsmdri
      421 ykqysprrrp gdpvcpfysh qlrskhlaik kmneiqknid gwegkdigqc cnefimegpl
      481 trigakherh iflfdglmis ckpnhgqtrl pgyssaeyrl kekfvmrkiq icdkedtceh
      541 khafelvskd ensiifaaks aeeknnwmaa lislhyrstl drmldsvllk eeneqplrlp
      601 spevyrfvvk dseenivfed nlqsrsgipi ikggtvvkli erltyhmyad pnfvrtfltt
      661 yrsfckpqel lsllierfei pepeptdadk laiekgeqpi sadlkrfrke yvqpvqlril
      721 nvfrhwvehh fydferdlel lerlesfiss vrgkamkkwv esiakiirrk kqaqangvsh
      781 nitfespppp iewhiskpgq fetfdlmtlh pieiarqltl lesdlyrkvq pselvgsvwt
      841 kedkeinspn llkmirhttn ltlwfekciv eaenfeerva vlsriieilq vfqdlnnfng
      901 vleivsavns vsvyrldhtf ealqerkrki ldeavelsqd hfkkylvklk sinppcvpff
      961 giyltnilkt eegnndflkk kgkdlinfsk rrkvaeitge iqqyqnqpyc lriepdmrrf
     1021 fenlnpmgsa sekeftdylf nksleieprn ckqpprfprk stfslkspgi rpntgrhgst
     1081 sgtlrghptp lerepckisf sriaeteles tvsaptspnt pstppvsass dlsvfldvdl
     1141 nsscgsnsif apvllphsks ffsscgslhk lseeplippp lpprkkfdhd asnskgnmks
     1201 dddppaippr qppppkvkpr vpvptgafdg plhspppppp rdplpdtppp vplrppehfi
     1261 ncpfnlqppp lghlhrdsdw lrdistcpns pstppstpsp rvprrcyvls ssqnnlahpp
     1321 appvpprqns sphlpklppk tykrelshpp lyrlpllena etpq
//
LOCUS       XP_047287672            1350 aa            linear   PRI 05-AUG-2025
DEFINITION  son of sevenless homolog 2 isoform X4 [Homo sapiens].
ACCESSION   XP_047287672
VERSION     XP_047287672.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431716.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1350
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1350
                     /product="son of sevenless homolog 2 isoform X4"
                     /calculated_mol_wt=154870
     Region          18..95
                     /region_name="HFD_SOS1_rpt1"
                     /note="first histone-fold domain found in son of sevenless
                     homolog 1 (SOS-1) and similar proteins; cd22914"
                     /db_xref="CDD:467039"
     Region          104..172
                     /region_name="HFD_SOS1_rpt2"
                     /note="second histone-fold domain found in son of
                     sevenless homolog 1 (SOS-1) and similar proteins; cd22915"
                     /db_xref="CDD:467040"
     Region          217..404
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
                     (DH) domain. It appears that PH domains invariably occur
                     C-terminal to RhoGEF/DH domains; cd00160"
                     /db_xref="CDD:238091"
     Site            order(223,227,328,356..357,360..361,363..364,367..368,
                     371..372,375,400,404)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          455..561
                     /region_name="PH_SOS"
                     /note="Son of Sevenless (SOS) Pleckstrin homology (PH)
                     domain; cd01261"
                     /db_xref="CDD:269963"
     Region          613..757
                     /region_name="RasGEFN"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     GTPases; N-terminal motif; smart00229"
                     /db_xref="CDD:214571"
     Site            order(632,699,703..704,707,710..711,744..745,748,755)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:100121"
     Region          792..1031
                     /region_name="RasGEF"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     small GTPases. Small GTP-binding proteins of the Ras
                     superfamily function as molecular switches in fundamental
                     events such as signal transduction, cytoskeleton dynamics
                     and intracellular trafficking; cd00155"
                     /db_xref="CDD:238087"
     Site            order(825..827,837..838,840..842,844..845,848..849,852,
                     885,888..889,891..893,895..898,900..901,921,927..929,932,
                     945..947,950..952,954..956,958..961,979,983,1023,
                     1026..1027)
                     /site_type="other"
                     /note="Ras interaction site [polypeptide binding]"
                     /db_xref="CDD:238087"
     CDS             1..1350
                     /gene="SOS2"
                     /gene_synonym="NS9; SOS-2"
                     /coded_by="XM_047431716.1:296..4348"
                     /db_xref="GeneID:6655"
                     /db_xref="HGNC:HGNC:11188"
                     /db_xref="MIM:601247"
ORIGIN      
        1 mqqapqpyef fseenspkwr gllvsalrkv qeqvhptlsa neeslyyiee lifqllnklc
       61 maqprtvqdv eervqktfph pidkwaiada qsaiekrkrr nplllpvdki hpslkevlgy
      121 kvdyhvslyi vavleyisad ilklagnyvf nirhyeisqq dikvsmcadk plvttfysas
      181 mslfqiphvl mdmfdqddig lvslcedeps ssgelnyydl vrteiaeerq ylrelnmiik
      241 vfreaflsdr klfkpsdiek ifsnisdihe ltvkllglie dtvemtdess phplagscfe
      301 dlaeeqafdp yetlsqdils pefhehfnkl marpavalhf qsiadgfkea vryvlprlml
      361 vpvyhcwhyf ellkqlkacs eeqedrecln qaitalmnlq gsmdriykqy sprrrpgdpv
      421 cpfyshqlrs khlaikkmne iqknidgweg kdigqccnef imegpltrig akherhiflf
      481 dglmisckpn hgqtrlpgys saeyrlkekf vmrkiqicdk edtcehkhaf elvskdensi
      541 ifaaksaeek nnwmaalisl hyrstldrml dsvllkeene qplrlpspev yrfvvkdsee
      601 nivfednlqs rsgipiikgg tvvklierlt yhmyadpnfv rtflttyrsf ckpqellsll
      661 ierfeipepe ptdadklaie kgeqpisadl krfrkeyvqp vqlrilnvfr hwvehhfydf
      721 erdlellerl esfissvrgk amkkwvesia kiirrkkqaq angvshnitf esppppiewh
      781 iskpgqfetf dlmtlhpiei arqltllesd lyrkvqpsel vgsvwtkedk einspnllkm
      841 irhttnltlw fekciveaen feervavlsr iieilqvfqd lnnfngvlei vsavnsvsvy
      901 rldhtfealq erkrkildea velsqdhfkk ylvklksinp pcvpffgiyl tnilkteegn
      961 ndflkkkgkd linfskrrkv aeitgeiqqy qnqpyclrie pdmrrffenl npmgsaseke
     1021 ftdylfnksl eieprnckqp prfprkstfs lkspgirpnt grhgstsgtl rghptplere
     1081 pckisfsria etelestvsa ptspntpstp pvsassdlsv fldvdlnssc gsnsifapvl
     1141 lphsksffss cgslhklsee plippplppr kkfdhdasns kgnmksdddp paipprqppp
     1201 pkvkprvpvp tgafdgplhs pppppprdpl pdtpppvplr ppehfincpf nlqppplghl
     1261 hrdsdwlrdi stcpnspstp pstpsprvpr rcyvlsssqn nlahppappv pprqnssphl
     1321 pklppktykr elshpplyrl pllenaetpq
//
LOCUS       XP_047287673            1346 aa            linear   PRI 05-AUG-2025
DEFINITION  son of sevenless homolog 2 isoform X5 [Homo sapiens].
ACCESSION   XP_047287673
VERSION     XP_047287673.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431717.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1346
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1346
                     /product="son of sevenless homolog 2 isoform X5"
                     /calculated_mol_wt=153653
     Region          18..142
                     /region_name="HFD_SOS1_rpt1"
                     /note="first histone-fold domain found in son of sevenless
                     homolog 1 (SOS-1) and similar proteins; cd22914"
                     /db_xref="CDD:467039"
     Region          151..223
                     /region_name="HFD_SOS1_rpt2"
                     /note="second histone-fold domain found in son of
                     sevenless homolog 1 (SOS-1) and similar proteins; cd22915"
                     /db_xref="CDD:467040"
     Region          254..401
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; smart00325"
                     /db_xref="CDD:214619"
     Region          451..557
                     /region_name="PH_SOS"
                     /note="Son of Sevenless (SOS) Pleckstrin homology (PH)
                     domain; cd01261"
                     /db_xref="CDD:269963"
     Region          609..753
                     /region_name="RasGEFN"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     GTPases; N-terminal motif; smart00229"
                     /db_xref="CDD:214571"
     Site            order(628,695,699..700,703,706..707,740..741,744,751)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:100121"
     Region          788..1027
                     /region_name="RasGEF"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     small GTPases. Small GTP-binding proteins of the Ras
                     superfamily function as molecular switches in fundamental
                     events such as signal transduction, cytoskeleton dynamics
                     and intracellular trafficking; cd00155"
                     /db_xref="CDD:238087"
     Site            order(821..823,833..834,836..838,840..841,844..845,848,
                     881,884..885,887..889,891..894,896..897,917,923..925,928,
                     941..943,946..948,950..952,954..957,975,979,1019,
                     1022..1023)
                     /site_type="other"
                     /note="Ras interaction site [polypeptide binding]"
                     /db_xref="CDD:238087"
     CDS             1..1346
                     /gene="SOS2"
                     /gene_synonym="NS9; SOS-2"
                     /coded_by="XM_047431717.1:296..4336"
                     /db_xref="GeneID:6655"
                     /db_xref="HGNC:HGNC:11188"
                     /db_xref="MIM:601247"
ORIGIN      
        1 mqqapqpyef fseenspkwr gllvsalrkm esrffarlgc sgailahcnl hlsgssdspa
       61 sasrvagttg vchhaqvqeq vhptlsanee slyyieelif qllnklcmaq prtvqdveer
      121 vqktfphpid kwaiadaqsa iekrkrrnpl llpvdkihps lkevlgykvd yhvslyivav
      181 leyisadilk lagnyvfnir hyeisqqdik vsmcadkvlm dmfdqddigl vslcedepss
      241 sgelnyydlv rteiaeerqy lrelnmiikv freaflsdrk lfkpsdieki fsnisdihel
      301 tvkllglied tvemtdessp hplagscfed laeeqafdpy etlsqdilsp efhehfnklm
      361 arpavalhfq qlkacseeqe dreclnqait almnlqgsmd riykqysprr rpgdpvcpfy
      421 shqlrskhla ikkmneiqkn idgwegkdig qccnefimeg pltrigakhe rhiflfdglm
      481 isckpnhgqt rlpgyssaey rlkekfvmrk iqicdkedtc ehkhafelvs kdensiifaa
      541 ksaeeknnwm aalislhyrs tldrmldsvl lkeeneqplr lpspevyrfv vkdseenivf
      601 ednlqsrsgi piikggtvvk lierltyhmy adpnfvrtfl ttyrsfckpq ellsllierf
      661 eipepeptda dklaiekgeq pisadlkrfr keyvqpvqlr ilnvfrhwve hhfydferdl
      721 ellerlesfi ssvrgkamkk wvesiakiir rkkqaqangv shnitfespp ppiewhiskp
      781 gqfetfdlmt lhpieiarql tllesdlyrk vqpselvgsv wtkedkeins pnllkmirht
      841 tnltlwfekc iveaenfeer vavlsriiei lqvfqdlnnf ngvleivsav nsvsvyrldh
      901 tfealqerkr kildeavels qdhfkkylvk lksinppcvp ffgiyltnil kteegnndfl
      961 kkkgkdlinf skrrkvaeit geiqqyqnqp yclriepdmr rffenlnpmg sasekeftdy
     1021 lfnksleiep rnckqpprfp rkstfslksp girpntgrhg stsgtlrghp tplerepcki
     1081 sfsriaetel estvsaptsp ntpstppvsa ssdlsvfldv dlnsscgsns ifapvllphs
     1141 ksffsscgsl hklseeplip pplpprkkfd hdasnskgnm ksdddppaip prqppppkvk
     1201 prvpvptgaf dgplhspppp pprdplpdtp ppvplrppeh fincpfnlqp pplghlhrds
     1261 dwlrdistcp nspstppstp sprvprrcyv lsssqnnlah ppappvpprq nssphlpklp
     1321 pktykrelsh pplyrlplle naetpq
//
LOCUS       XP_047287674            1337 aa            linear   PRI 05-AUG-2025
DEFINITION  son of sevenless homolog 2 isoform X6 [Homo sapiens].
ACCESSION   XP_047287674
VERSION     XP_047287674.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431718.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 7% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1337
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1337
                     /product="son of sevenless homolog 2 isoform X6"
                     /calculated_mol_wt=153397
     Region          17..82
                     /region_name="HFD_SOS1_rpt1"
                     /note="first histone-fold domain found in son of sevenless
                     homolog 1 (SOS-1) and similar proteins; cd22914"
                     /db_xref="CDD:467039"
     Region          91..159
                     /region_name="HFD_SOS1_rpt2"
                     /note="second histone-fold domain found in son of
                     sevenless homolog 1 (SOS-1) and similar proteins; cd22915"
                     /db_xref="CDD:467040"
     Region          204..391
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
                     (DH) domain. It appears that PH domains invariably occur
                     C-terminal to RhoGEF/DH domains; cd00160"
                     /db_xref="CDD:238091"
     Site            order(210,214,315,343..344,347..348,350..351,354..355,
                     358..359,362,387,391)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          442..548
                     /region_name="PH_SOS"
                     /note="Son of Sevenless (SOS) Pleckstrin homology (PH)
                     domain; cd01261"
                     /db_xref="CDD:269963"
     Region          600..744
                     /region_name="RasGEFN"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     GTPases; N-terminal motif; smart00229"
                     /db_xref="CDD:214571"
     Site            order(619,686,690..691,694,697..698,731..732,735,742)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:100121"
     Region          779..1018
                     /region_name="RasGEF"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     small GTPases. Small GTP-binding proteins of the Ras
                     superfamily function as molecular switches in fundamental
                     events such as signal transduction, cytoskeleton dynamics
                     and intracellular trafficking; cd00155"
                     /db_xref="CDD:238087"
     Site            order(812..814,824..825,827..829,831..832,835..836,839,
                     872,875..876,878..880,882..885,887..888,908,914..916,919,
                     932..934,937..939,941..943,945..948,966,970,1010,
                     1013..1014)
                     /site_type="other"
                     /note="Ras interaction site [polypeptide binding]"
                     /db_xref="CDD:238087"
     CDS             1..1337
                     /gene="SOS2"
                     /gene_synonym="NS9; SOS-2"
                     /coded_by="XM_047431718.1:394..4407"
                     /db_xref="GeneID:6655"
                     /db_xref="HGNC:HGNC:11188"
                     /db_xref="MIM:601247"
ORIGIN      
        1 mvlfhcpldv llqhlwvqeq vhptlsanee slyyieelif qllnklcmaq prtvqdveer
       61 vqktfphpid kwaiadaqsa iekrkrrnpl llpvdkihps lkevlgykvd yhvslyivav
      121 leyisadilk lagnyvfnir hyeisqqdik vsmcadkplv ttfysasmsl fqiphvlmdm
      181 fdqddiglvs lcedepsssg elnyydlvrt eiaeerqylr elnmiikvfr eaflsdrklf
      241 kpsdiekifs nisdiheltv kllgliedtv emtdessphp lagscfedla eeqafdpyet
      301 lsqdilspef hehfnklmar pavalhfqsi adgfkeavry vlprlmlvpv yhcwhyfell
      361 kqlkacseeq edreclnqai talmnlqgsm driykqyspr rrpgdpvcpf yshqlrskhl
      421 aikkmneiqk nidgwegkdi gqccnefime gpltrigakh erhiflfdgl misckpnhgq
      481 trlpgyssae yrlkekfvmr kiqicdkedt cehkhafelv skdensiifa aksaeeknnw
      541 maalislhyr stldrmldsv llkeeneqpl rlpspevyrf vvkdseeniv fednlqsrsg
      601 ipiikggtvv klierltyhm yadpnfvrtf lttyrsfckp qellsllier feipepeptd
      661 adklaiekge qpisadlkrf rkeyvqpvql rilnvfrhwv ehhfydferd lellerlesf
      721 issvrgkamk kwvesiakii rrkkqaqang vshnitfesp pppiewhisk pgqfetfdlm
      781 tlhpieiarq ltllesdlyr kvqpselvgs vwtkedkein spnllkmirh ttnltlwfek
      841 civeaenfee rvavlsriie ilqvfqdlnn fngvleivsa vnsvsvyrld htfealqerk
      901 rkildeavel sqdhfkkylv klksinppcv pffgiyltni lkteegnndf lkkkgkdlin
      961 fskrrkvaei tgeiqqyqnq pyclriepdm rrffenlnpm gsasekeftd ylfnksleie
     1021 prnckqpprf prkstfslks pgirpntgrh gstsgtlrgh ptplerepck isfsriaete
     1081 lestvsapts pntpstppvs assdlsvfld vdlnsscgsn sifapvllph sksffsscgs
     1141 lhklseepli ppplpprkkf dhdasnskgn mksdddppai pprqppppkv kprvpvptga
     1201 fdgplhsppp ppprdplpdt pppvplrppe hfincpfnlq ppplghlhrd sdwlrdistc
     1261 pnspstppst psprvprrcy vlsssqnnla hppappvppr qnssphlpkl ppktykrels
     1321 hpplyrlpll enaetpq
//
LOCUS       XP_047287675            1319 aa            linear   PRI 05-AUG-2025
DEFINITION  son of sevenless homolog 2 isoform X7 [Homo sapiens].
ACCESSION   XP_047287675
VERSION     XP_047287675.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431719.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 7% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1319
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1319
                     /product="son of sevenless homolog 2 isoform X7"
                     /calculated_mol_wt=151375
     Region          17..82
                     /region_name="HFD_SOS1_rpt1"
                     /note="first histone-fold domain found in son of sevenless
                     homolog 1 (SOS-1) and similar proteins; cd22914"
                     /db_xref="CDD:467039"
     Region          91..163
                     /region_name="HFD_SOS1_rpt2"
                     /note="second histone-fold domain found in son of
                     sevenless homolog 1 (SOS-1) and similar proteins; cd22915"
                     /db_xref="CDD:467040"
     Region          186..373
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
                     (DH) domain. It appears that PH domains invariably occur
                     C-terminal to RhoGEF/DH domains; cd00160"
                     /db_xref="CDD:238091"
     Site            order(192,196,297,325..326,329..330,332..333,336..337,
                     340..341,344,369,373)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          424..530
                     /region_name="PH_SOS"
                     /note="Son of Sevenless (SOS) Pleckstrin homology (PH)
                     domain; cd01261"
                     /db_xref="CDD:269963"
     Region          582..726
                     /region_name="RasGEFN"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     GTPases; N-terminal motif; smart00229"
                     /db_xref="CDD:214571"
     Site            order(601,668,672..673,676,679..680,713..714,717,724)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:100121"
     Region          761..1000
                     /region_name="RasGEF"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     small GTPases. Small GTP-binding proteins of the Ras
                     superfamily function as molecular switches in fundamental
                     events such as signal transduction, cytoskeleton dynamics
                     and intracellular trafficking; cd00155"
                     /db_xref="CDD:238087"
     Site            order(794..796,806..807,809..811,813..814,817..818,821,
                     854,857..858,860..862,864..867,869..870,890,896..898,901,
                     914..916,919..921,923..925,927..930,948,952,992,995..996)
                     /site_type="other"
                     /note="Ras interaction site [polypeptide binding]"
                     /db_xref="CDD:238087"
     CDS             1..1319
                     /gene="SOS2"
                     /gene_synonym="NS9; SOS-2"
                     /coded_by="XM_047431719.1:394..4353"
                     /db_xref="GeneID:6655"
                     /db_xref="HGNC:HGNC:11188"
                     /db_xref="MIM:601247"
ORIGIN      
        1 mvlfhcpldv llqhlwvqeq vhptlsanee slyyieelif qllnklcmaq prtvqdveer
       61 vqktfphpid kwaiadaqsa iekrkrrnpl llpvdkihps lkevlgykvd yhvslyivav
      121 leyisadilk lagnyvfnir hyeisqqdik vsmcadkvlm dmfdqddigl vslcedepss
      181 sgelnyydlv rteiaeerqy lrelnmiikv freaflsdrk lfkpsdieki fsnisdihel
      241 tvkllglied tvemtdessp hplagscfed laeeqafdpy etlsqdilsp efhehfnklm
      301 arpavalhfq siadgfkeav ryvlprlmlv pvyhcwhyfe llkqlkacse eqedreclnq
      361 aitalmnlqg smdriykqys prrrpgdpvc pfyshqlrsk hlaikkmnei qknidgwegk
      421 digqccnefi megpltriga kherhiflfd glmisckpnh gqtrlpgyss aeyrlkekfv
      481 mrkiqicdke dtcehkhafe lvskdensii faaksaeekn nwmaalislh yrstldrmld
      541 svllkeeneq plrlpspevy rfvvkdseen ivfednlqsr sgipiikggt vvklierlty
      601 hmyadpnfvr tflttyrsfc kpqellslli erfeipepep tdadklaiek geqpisadlk
      661 rfrkeyvqpv qlrilnvfrh wvehhfydfe rdlellerle sfissvrgka mkkwvesiak
      721 iirrkkqaqa ngvshnitfe sppppiewhi skpgqfetfd lmtlhpieia rqltllesdl
      781 yrkvqpselv gsvwtkedke inspnllkmi rhttnltlwf ekciveaenf eervavlsri
      841 ieilqvfqdl nnfngvleiv savnsvsvyr ldhtfealqe rkrkildeav elsqdhfkky
      901 lvklksinpp cvpffgiylt nilkteegnn dflkkkgkdl infskrrkva eitgeiqqyq
      961 nqpyclriep dmrrffenln pmgsasekef tdylfnksle ieprnckqpp rfprkstfsl
     1021 kspgirpntg rhgstsgtlr ghptplerep ckisfsriae telestvsap tspntpstpp
     1081 vsassdlsvf ldvdlnsscg snsifapvll phsksffssc gslhklseep lippplpprk
     1141 kfdhdasnsk gnmksdddpp aipprqpppp kvkprvpvpt gafdgplhsp ppppprdplp
     1201 dtpppvplrp pehfincpfn lqppplghlh rdsdwlrdis tcpnspstpp stpsprvprr
     1261 cyvlsssqnn lahppappvp prqnssphlp klppktykre lshpplyrlp llenaetpq
//
LOCUS       XP_047287678            1290 aa            linear   PRI 05-AUG-2025
DEFINITION  son of sevenless homolog 2 isoform X8 [Homo sapiens].
ACCESSION   XP_047287678
VERSION     XP_047287678.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431722.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1290
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1290
                     /product="son of sevenless homolog 2 isoform X8"
                     /calculated_mol_wt=147803
     Region          <1..35
                     /region_name="HFD_SF"
                     /note="histone fold domain (HFD) superfamily; cl45933"
                     /db_xref="CDD:480273"
     Region          44..112
                     /region_name="HFD_SOS1_rpt2"
                     /note="second histone-fold domain found in son of
                     sevenless homolog 1 (SOS-1) and similar proteins; cd22915"
                     /db_xref="CDD:467040"
     Region          157..344
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
                     (DH) domain. It appears that PH domains invariably occur
                     C-terminal to RhoGEF/DH domains; cd00160"
                     /db_xref="CDD:238091"
     Site            order(163,167,268,296..297,300..301,303..304,307..308,
                     311..312,315,340,344)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          395..501
                     /region_name="PH_SOS"
                     /note="Son of Sevenless (SOS) Pleckstrin homology (PH)
                     domain; cd01261"
                     /db_xref="CDD:269963"
     Region          553..697
                     /region_name="RasGEFN"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     GTPases; N-terminal motif; smart00229"
                     /db_xref="CDD:214571"
     Site            order(572,639,643..644,647,650..651,684..685,688,695)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:100121"
     Region          732..971
                     /region_name="RasGEF"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     small GTPases. Small GTP-binding proteins of the Ras
                     superfamily function as molecular switches in fundamental
                     events such as signal transduction, cytoskeleton dynamics
                     and intracellular trafficking; cd00155"
                     /db_xref="CDD:238087"
     Site            order(765..767,777..778,780..782,784..785,788..789,792,
                     825,828..829,831..833,835..838,840..841,861,867..869,872,
                     885..887,890..892,894..896,898..901,919,923,963,966..967)
                     /site_type="other"
                     /note="Ras interaction site [polypeptide binding]"
                     /db_xref="CDD:238087"
     CDS             1..1290
                     /gene="SOS2"
                     /gene_synonym="NS9; SOS-2"
                     /coded_by="XM_047431722.1:375..4247"
                     /db_xref="GeneID:6655"
                     /db_xref="HGNC:HGNC:11188"
                     /db_xref="MIM:601247"
ORIGIN      
        1 maqprtvqdv eervqktfph pidkwaiada qsaiekrkrr nplllpvdki hpslkevlgy
       61 kvdyhvslyi vavleyisad ilklagnyvf nirhyeisqq dikvsmcadk plvttfysas
      121 mslfqiphvl mdmfdqddig lvslcedeps ssgelnyydl vrteiaeerq ylrelnmiik
      181 vfreaflsdr klfkpsdiek ifsnisdihe ltvkllglie dtvemtdess phplagscfe
      241 dlaeeqafdp yetlsqdils pefhehfnkl marpavalhf qsiadgfkea vryvlprlml
      301 vpvyhcwhyf ellkqlkacs eeqedrecln qaitalmnlq gsmdriykqy sprrrpgdpv
      361 cpfyshqlrs khlaikkmne iqknidgweg kdigqccnef imegpltrig akherhiflf
      421 dglmisckpn hgqtrlpgys saeyrlkekf vmrkiqicdk edtcehkhaf elvskdensi
      481 ifaaksaeek nnwmaalisl hyrstldrml dsvllkeene qplrlpspev yrfvvkdsee
      541 nivfednlqs rsgipiikgg tvvklierlt yhmyadpnfv rtflttyrsf ckpqellsll
      601 ierfeipepe ptdadklaie kgeqpisadl krfrkeyvqp vqlrilnvfr hwvehhfydf
      661 erdlellerl esfissvrgk amkkwvesia kiirrkkqaq angvshnitf esppppiewh
      721 iskpgqfetf dlmtlhpiei arqltllesd lyrkvqpsel vgsvwtkedk einspnllkm
      781 irhttnltlw fekciveaen feervavlsr iieilqvfqd lnnfngvlei vsavnsvsvy
      841 rldhtfealq erkrkildea velsqdhfkk ylvklksinp pcvpffgiyl tnilkteegn
      901 ndflkkkgkd linfskrrkv aeitgeiqqy qnqpyclrie pdmrrffenl npmgsaseke
      961 ftdylfnksl eieprnckqp prfprkstfs lkspgirpnt grhgstsgtl rghptplere
     1021 pckisfsria etelestvsa ptspntpstp pvsassdlsv fldvdlnssc gsnsifapvl
     1081 lphsksffss cgslhklsee plippplppr kkfdhdasns kgnmksdddp paipprqppp
     1141 pkvkprvpvp tgafdgplhs pppppprdpl pdtpppvplr ppehfincpf nlqppplghl
     1201 hrdsdwlrdi stcpnspstp pstpsprvpr rcyvlsssqn nlahppappv pprqnssphl
     1261 pklppktykr elshpplyrl pllenaetpq
//
LOCUS       XP_047287679            1290 aa            linear   PRI 05-AUG-2025
DEFINITION  son of sevenless homolog 2 isoform X8 [Homo sapiens].
ACCESSION   XP_047287679
VERSION     XP_047287679.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431723.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1290
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1290
                     /product="son of sevenless homolog 2 isoform X8"
                     /calculated_mol_wt=147803
     Region          <1..35
                     /region_name="HFD_SF"
                     /note="histone fold domain (HFD) superfamily; cl45933"
                     /db_xref="CDD:480273"
     Region          44..112
                     /region_name="HFD_SOS1_rpt2"
                     /note="second histone-fold domain found in son of
                     sevenless homolog 1 (SOS-1) and similar proteins; cd22915"
                     /db_xref="CDD:467040"
     Region          157..344
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
                     (DH) domain. It appears that PH domains invariably occur
                     C-terminal to RhoGEF/DH domains; cd00160"
                     /db_xref="CDD:238091"
     Site            order(163,167,268,296..297,300..301,303..304,307..308,
                     311..312,315,340,344)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          395..501
                     /region_name="PH_SOS"
                     /note="Son of Sevenless (SOS) Pleckstrin homology (PH)
                     domain; cd01261"
                     /db_xref="CDD:269963"
     Region          553..697
                     /region_name="RasGEFN"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     GTPases; N-terminal motif; smart00229"
                     /db_xref="CDD:214571"
     Site            order(572,639,643..644,647,650..651,684..685,688,695)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:100121"
     Region          732..971
                     /region_name="RasGEF"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     small GTPases. Small GTP-binding proteins of the Ras
                     superfamily function as molecular switches in fundamental
                     events such as signal transduction, cytoskeleton dynamics
                     and intracellular trafficking; cd00155"
                     /db_xref="CDD:238087"
     Site            order(765..767,777..778,780..782,784..785,788..789,792,
                     825,828..829,831..833,835..838,840..841,861,867..869,872,
                     885..887,890..892,894..896,898..901,919,923,963,966..967)
                     /site_type="other"
                     /note="Ras interaction site [polypeptide binding]"
                     /db_xref="CDD:238087"
     CDS             1..1290
                     /gene="SOS2"
                     /gene_synonym="NS9; SOS-2"
                     /coded_by="XM_047431723.1:204..4076"
                     /db_xref="GeneID:6655"
                     /db_xref="HGNC:HGNC:11188"
                     /db_xref="MIM:601247"
ORIGIN      
        1 maqprtvqdv eervqktfph pidkwaiada qsaiekrkrr nplllpvdki hpslkevlgy
       61 kvdyhvslyi vavleyisad ilklagnyvf nirhyeisqq dikvsmcadk plvttfysas
      121 mslfqiphvl mdmfdqddig lvslcedeps ssgelnyydl vrteiaeerq ylrelnmiik
      181 vfreaflsdr klfkpsdiek ifsnisdihe ltvkllglie dtvemtdess phplagscfe
      241 dlaeeqafdp yetlsqdils pefhehfnkl marpavalhf qsiadgfkea vryvlprlml
      301 vpvyhcwhyf ellkqlkacs eeqedrecln qaitalmnlq gsmdriykqy sprrrpgdpv
      361 cpfyshqlrs khlaikkmne iqknidgweg kdigqccnef imegpltrig akherhiflf
      421 dglmisckpn hgqtrlpgys saeyrlkekf vmrkiqicdk edtcehkhaf elvskdensi
      481 ifaaksaeek nnwmaalisl hyrstldrml dsvllkeene qplrlpspev yrfvvkdsee
      541 nivfednlqs rsgipiikgg tvvklierlt yhmyadpnfv rtflttyrsf ckpqellsll
      601 ierfeipepe ptdadklaie kgeqpisadl krfrkeyvqp vqlrilnvfr hwvehhfydf
      661 erdlellerl esfissvrgk amkkwvesia kiirrkkqaq angvshnitf esppppiewh
      721 iskpgqfetf dlmtlhpiei arqltllesd lyrkvqpsel vgsvwtkedk einspnllkm
      781 irhttnltlw fekciveaen feervavlsr iieilqvfqd lnnfngvlei vsavnsvsvy
      841 rldhtfealq erkrkildea velsqdhfkk ylvklksinp pcvpffgiyl tnilkteegn
      901 ndflkkkgkd linfskrrkv aeitgeiqqy qnqpyclrie pdmrrffenl npmgsaseke
      961 ftdylfnksl eieprnckqp prfprkstfs lkspgirpnt grhgstsgtl rghptplere
     1021 pckisfsria etelestvsa ptspntpstp pvsassdlsv fldvdlnssc gsnsifapvl
     1081 lphsksffss cgslhklsee plippplppr kkfdhdasns kgnmksdddp paipprqppp
     1141 pkvkprvpvp tgafdgplhs pppppprdpl pdtpppvplr ppehfincpf nlqppplghl
     1201 hrdsdwlrdi stcpnspstp pstpsprvpr rcyvlsssqn nlahppappv pprqnssphl
     1261 pklppktykr elshpplyrl pllenaetpq
//
LOCUS       XP_047287680            2328 aa            linear   PRI 05-AUG-2025
DEFINITION  spectrin beta chain, erythrocytic isoform X1 [Homo sapiens].
ACCESSION   XP_047287680
VERSION     XP_047287680.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431724.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2328
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2328
                     /product="spectrin beta chain, erythrocytic isoform X1"
                     /calculated_mol_wt=267696
     Region          25..156
                     /region_name="CH_SPTBN2_rpt1"
                     /note="first calponin homology (CH) domain found in
                     spectrin beta chain, non-erythrocytic 2 (SPTBN2) and
                     similar proteins; cd21317"
                     /db_xref="CDD:409166"
     Site            order(37..38,41,44..45,48..49,52..53,56,110,113..114,117,
                     124,129..137,144..145,147..148,151..152,155..156)
                     /site_type="other"
                     /note="actin binding site [polypeptide binding]"
                     /db_xref="CDD:409166"
     Region          170..281
                     /region_name="CH_SPTB_rpt2"
                     /note="second calponin homology (CH) domain found in
                     spectrin beta chain, erythrocytic (SPTB) and similar
                     proteins; cd21319"
                     /db_xref="CDD:409168"
     Site            order(175,179,229,231..232,235,242,247..255,264..265,
                     267..268,271..272,275)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409168"
     Region          302..412
                     /region_name="Spectrin"
                     /note="Spectrin repeat; pfam00435"
                     /db_xref="CDD:395348"
     Region          422..525
                     /region_name="Spectrin"
                     /note="Spectrin repeat; pfam00435"
                     /db_xref="CDD:395348"
     Region          530..742
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            636..641
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          641..848
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            742..747
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          745..954
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            847..852
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          955..1168
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1060..1065
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1170..1379
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1273..1278
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1385..1475
                     /region_name="SPEC"
                     /note="Spectrin repeats; smart00150"
                     /db_xref="CDD:197544"
     Region          1485..1690
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1583..1588
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1691..1901
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1796..1801
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1798..2005
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1902..1907
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          2013..>2070
                     /region_name="Spectrin"
                     /note="Spectrin repeat; pfam00435"
                     /db_xref="CDD:395348"
     Region          2181..2286
                     /region_name="PH_beta_spectrin"
                     /note="Beta-spectrin pleckstrin homology (PH) domain;
                     cd10571"
                     /db_xref="CDD:269975"
     Site            order(2188,2201..2203,2249)
                     /site_type="other"
                     /note="non-cannonical phosphoinositide binding site
                     [chemical binding]"
                     /db_xref="CDD:269975"
     CDS             1..2328
                     /gene="SPTB"
                     /gene_synonym="EL3; HS2; HSPTB1; SPH2"
                     /coded_by="XM_047431724.1:337..7323"
                     /db_xref="GeneID:6710"
                     /db_xref="HGNC:HGNC:11274"
                     /db_xref="MIM:182870"
ORIGIN      
        1 mtsatefenv gnqppysrin arwdapddel dndnssarlf ersrikalad erevvqkktf
       61 tkwvnshlar vscritdlyk dlrdgrmlik llevlsgeml pkptkgkmri hclenvdkal
      121 qflkeqrvhl enmgshdivd gnhrlvlgli wtiilrfqiq divvqtqegr etrsakdall
      181 lwcqmktagy phvnvtnfts swkdglafna lihkhrpdli dfdklkdsna rhnlehafnv
      241 aerqlgiipl ldpedvften pdeksiityv vafyhyfskm kvlavegkrv gkvidhaiet
      301 ekmiekysgl asdlltwieq titvlnsrkf ansltgvqqq lqafstyrtv ekppkfqekg
      361 nlevllftiq srmrannqkv ytphdgklvs dinrawesle eaeyrrelal rnelirqekl
      421 eqlarrfdrk aamretwlse nqrlvaqdnf gydlaaveaa kkkheaietd taayeervra
      481 ledlaqelek enyhdqkrit arkdnilrlw sylqellqsr rqrlettlal qklfqdmlhs
      541 idwmdeikah llsaefgkhl levedllqkh klmeadiaiq gdkvkaitaa tlkftegkgy
      601 qpcdpqviqd rishleqcfe elsnmaagrk aqleqskrlw kffwemdeae swikekeqiy
      661 ssldygkdlt svlilqrkhk afedelrgld ahleqifqea hgmvarkqfg hpqiearike
      721 vsaqwdqlkd laafckknlq daenffqfqg daddlkawlq dahrllsged vgqdegatra
      781 lgkkhkdfle eleesrgvme hleqqaqgfp eefrdspdvt hrlqalrely qqvvaqadlr
      841 qqrlqealdl ytvfgetdac elwmgekekw laemempdtl edlevvqhrf dildqemktl
      901 mtqidgvnla anslvesghp rsrevkqyqd hlntrwqafq tlvserreav dsalrvhnyc
      961 vdceetskwi tdktkvvest kdlgrdlagi iaiqrklsgl erdvaaiqar vdaleresqq
     1021 lmdshpeqke digqrqkhle elwqglqqsl qgqedllgev sqlqaflqdl ddfqawlsit
     1081 qkavasedmp eslpeaeqll qqhagikdei dghqdsyqrv kesgekviqg qtdpeylllg
     1141 qrlegldtgw nalgrmwesr shtlaqclgf qefqkdakqa eailsnqeyt lahleppdsl
     1201 eaaeagirkf edflgsmenn rdkvlspvds gnklvaegnl ysdkikekvq liedrhrknn
     1261 ekaqeasvll rdnlelqnfl qncqeltlwi ndklltsqdv sydearnlhn kwlkhqafva
     1321 elashegwle nidaegkqlm dekpqftalv sqklealhrl wdelqattke ktqhlsaars
     1381 sdlrlqthad lnkwisamed qlrsddpgkd ltsvnrmlak lkrvedqvnv rkeelgelfa
     1441 qvpsmgeegg dadlsiekrf ldlleplgrr kkqlessrak lqisrdlede tlwveerlpl
     1501 aqsadygtnl qtvqlfmkkn qtlqneilgh tprvedvlqr gqqlveaaei dcqdleerlg
     1561 hlqsswdrlr eaaagrlqrl rdaneaqqyy ldadeaeawi geqelyvisd eipkdeegai
     1621 vmlkrhlrqq ravedygrni kqlasraqgl lsaghpegeq iirlqgqvdk hyaglkdvae
     1681 erkrklenmy hlfqlkretd dleqwiseke lvasspemgq dfdhvtllrd kfrdfaretg
     1741 aigqervdnv nafierlida ghseaatiae wkdglnemwa dllelidtrm qllaasydlh
     1801 ryfytgaeil glidekhrel pedvgldast aesfhrvhta ferelhllgv qvqqfqdvat
     1861 rlqtayagek aeaiqnkeqe vsaawqalld acagrrtqlv dtadkfrffs mardllswme
     1921 siirqietqe rprdvssvel lmkyhqgina eietrsknfs aclelgesll qrqhqaseei
     1981 reklqqvmsr rkemnekwea rwerlrmlle vcqfsrdasv aeawliaqep ylasgdfght
     2041 vdsveklikr heafekstas waerfaalek pttlelkerq iaerpaeetg pqeeegetag
     2101 eapvshhaat ertspgeeeg twpqnlqqpp ppgqhkdgqk stgderptte plfkvldtpl
     2161 segdepatlp aprdhgqsvq megylgrkhd legpnkkasn rswnnlycvl rnseltfykd
     2221 aknlalgmpy hgeeplalrh aiceiaanyk kkkhvfklrl sngsewlfhg kdeeemlswl
     2281 qgvstaines qsirvkaqsl plpslsgpda slgkkdkekr fsffpkkk
//
LOCUS       XP_047287681            2328 aa            linear   PRI 05-AUG-2025
DEFINITION  spectrin beta chain, erythrocytic isoform X1 [Homo sapiens].
ACCESSION   XP_047287681
VERSION     XP_047287681.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431725.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2328
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2328
                     /product="spectrin beta chain, erythrocytic isoform X1"
                     /calculated_mol_wt=267696
     Region          25..156
                     /region_name="CH_SPTBN2_rpt1"
                     /note="first calponin homology (CH) domain found in
                     spectrin beta chain, non-erythrocytic 2 (SPTBN2) and
                     similar proteins; cd21317"
                     /db_xref="CDD:409166"
     Site            order(37..38,41,44..45,48..49,52..53,56,110,113..114,117,
                     124,129..137,144..145,147..148,151..152,155..156)
                     /site_type="other"
                     /note="actin binding site [polypeptide binding]"
                     /db_xref="CDD:409166"
     Region          170..281
                     /region_name="CH_SPTB_rpt2"
                     /note="second calponin homology (CH) domain found in
                     spectrin beta chain, erythrocytic (SPTB) and similar
                     proteins; cd21319"
                     /db_xref="CDD:409168"
     Site            order(175,179,229,231..232,235,242,247..255,264..265,
                     267..268,271..272,275)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409168"
     Region          302..412
                     /region_name="Spectrin"
                     /note="Spectrin repeat; pfam00435"
                     /db_xref="CDD:395348"
     Region          422..525
                     /region_name="Spectrin"
                     /note="Spectrin repeat; pfam00435"
                     /db_xref="CDD:395348"
     Region          530..742
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            636..641
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          641..848
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            742..747
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          745..954
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            847..852
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          955..1168
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1060..1065
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1170..1379
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1273..1278
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1385..1475
                     /region_name="SPEC"
                     /note="Spectrin repeats; smart00150"
                     /db_xref="CDD:197544"
     Region          1485..1690
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1583..1588
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1691..1901
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1796..1801
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1798..2005
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1902..1907
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          2013..>2070
                     /region_name="Spectrin"
                     /note="Spectrin repeat; pfam00435"
                     /db_xref="CDD:395348"
     Region          2181..2286
                     /region_name="PH_beta_spectrin"
                     /note="Beta-spectrin pleckstrin homology (PH) domain;
                     cd10571"
                     /db_xref="CDD:269975"
     Site            order(2188,2201..2203,2249)
                     /site_type="other"
                     /note="non-cannonical phosphoinositide binding site
                     [chemical binding]"
                     /db_xref="CDD:269975"
     CDS             1..2328
                     /gene="SPTB"
                     /gene_synonym="EL3; HS2; HSPTB1; SPH2"
                     /coded_by="XM_047431725.1:1255..8241"
                     /db_xref="GeneID:6710"
                     /db_xref="HGNC:HGNC:11274"
                     /db_xref="MIM:182870"
ORIGIN      
        1 mtsatefenv gnqppysrin arwdapddel dndnssarlf ersrikalad erevvqkktf
       61 tkwvnshlar vscritdlyk dlrdgrmlik llevlsgeml pkptkgkmri hclenvdkal
      121 qflkeqrvhl enmgshdivd gnhrlvlgli wtiilrfqiq divvqtqegr etrsakdall
      181 lwcqmktagy phvnvtnfts swkdglafna lihkhrpdli dfdklkdsna rhnlehafnv
      241 aerqlgiipl ldpedvften pdeksiityv vafyhyfskm kvlavegkrv gkvidhaiet
      301 ekmiekysgl asdlltwieq titvlnsrkf ansltgvqqq lqafstyrtv ekppkfqekg
      361 nlevllftiq srmrannqkv ytphdgklvs dinrawesle eaeyrrelal rnelirqekl
      421 eqlarrfdrk aamretwlse nqrlvaqdnf gydlaaveaa kkkheaietd taayeervra
      481 ledlaqelek enyhdqkrit arkdnilrlw sylqellqsr rqrlettlal qklfqdmlhs
      541 idwmdeikah llsaefgkhl levedllqkh klmeadiaiq gdkvkaitaa tlkftegkgy
      601 qpcdpqviqd rishleqcfe elsnmaagrk aqleqskrlw kffwemdeae swikekeqiy
      661 ssldygkdlt svlilqrkhk afedelrgld ahleqifqea hgmvarkqfg hpqiearike
      721 vsaqwdqlkd laafckknlq daenffqfqg daddlkawlq dahrllsged vgqdegatra
      781 lgkkhkdfle eleesrgvme hleqqaqgfp eefrdspdvt hrlqalrely qqvvaqadlr
      841 qqrlqealdl ytvfgetdac elwmgekekw laemempdtl edlevvqhrf dildqemktl
      901 mtqidgvnla anslvesghp rsrevkqyqd hlntrwqafq tlvserreav dsalrvhnyc
      961 vdceetskwi tdktkvvest kdlgrdlagi iaiqrklsgl erdvaaiqar vdaleresqq
     1021 lmdshpeqke digqrqkhle elwqglqqsl qgqedllgev sqlqaflqdl ddfqawlsit
     1081 qkavasedmp eslpeaeqll qqhagikdei dghqdsyqrv kesgekviqg qtdpeylllg
     1141 qrlegldtgw nalgrmwesr shtlaqclgf qefqkdakqa eailsnqeyt lahleppdsl
     1201 eaaeagirkf edflgsmenn rdkvlspvds gnklvaegnl ysdkikekvq liedrhrknn
     1261 ekaqeasvll rdnlelqnfl qncqeltlwi ndklltsqdv sydearnlhn kwlkhqafva
     1321 elashegwle nidaegkqlm dekpqftalv sqklealhrl wdelqattke ktqhlsaars
     1381 sdlrlqthad lnkwisamed qlrsddpgkd ltsvnrmlak lkrvedqvnv rkeelgelfa
     1441 qvpsmgeegg dadlsiekrf ldlleplgrr kkqlessrak lqisrdlede tlwveerlpl
     1501 aqsadygtnl qtvqlfmkkn qtlqneilgh tprvedvlqr gqqlveaaei dcqdleerlg
     1561 hlqsswdrlr eaaagrlqrl rdaneaqqyy ldadeaeawi geqelyvisd eipkdeegai
     1621 vmlkrhlrqq ravedygrni kqlasraqgl lsaghpegeq iirlqgqvdk hyaglkdvae
     1681 erkrklenmy hlfqlkretd dleqwiseke lvasspemgq dfdhvtllrd kfrdfaretg
     1741 aigqervdnv nafierlida ghseaatiae wkdglnemwa dllelidtrm qllaasydlh
     1801 ryfytgaeil glidekhrel pedvgldast aesfhrvhta ferelhllgv qvqqfqdvat
     1861 rlqtayagek aeaiqnkeqe vsaawqalld acagrrtqlv dtadkfrffs mardllswme
     1921 siirqietqe rprdvssvel lmkyhqgina eietrsknfs aclelgesll qrqhqaseei
     1981 reklqqvmsr rkemnekwea rwerlrmlle vcqfsrdasv aeawliaqep ylasgdfght
     2041 vdsveklikr heafekstas waerfaalek pttlelkerq iaerpaeetg pqeeegetag
     2101 eapvshhaat ertspgeeeg twpqnlqqpp ppgqhkdgqk stgderptte plfkvldtpl
     2161 segdepatlp aprdhgqsvq megylgrkhd legpnkkasn rswnnlycvl rnseltfykd
     2221 aknlalgmpy hgeeplalrh aiceiaanyk kkkhvfklrl sngsewlfhg kdeeemlswl
     2281 qgvstaines qsirvkaqsl plpslsgpda slgkkdkekr fsffpkkk
//
LOCUS       XP_024305467            2328 aa            linear   PRI 05-AUG-2025
DEFINITION  spectrin beta chain, erythrocytic isoform X1 [Homo sapiens].
ACCESSION   XP_024305467
VERSION     XP_024305467.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449699.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2328
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2328
                     /product="spectrin beta chain, erythrocytic isoform X1"
                     /calculated_mol_wt=267696
     Region          25..156
                     /region_name="CH_SPTBN2_rpt1"
                     /note="first calponin homology (CH) domain found in
                     spectrin beta chain, non-erythrocytic 2 (SPTBN2) and
                     similar proteins; cd21317"
                     /db_xref="CDD:409166"
     Site            order(37..38,41,44..45,48..49,52..53,56,110,113..114,117,
                     124,129..137,144..145,147..148,151..152,155..156)
                     /site_type="other"
                     /note="actin binding site [polypeptide binding]"
                     /db_xref="CDD:409166"
     Region          170..281
                     /region_name="CH_SPTB_rpt2"
                     /note="second calponin homology (CH) domain found in
                     spectrin beta chain, erythrocytic (SPTB) and similar
                     proteins; cd21319"
                     /db_xref="CDD:409168"
     Site            order(175,179,229,231..232,235,242,247..255,264..265,
                     267..268,271..272,275)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409168"
     Region          302..412
                     /region_name="Spectrin"
                     /note="Spectrin repeat; pfam00435"
                     /db_xref="CDD:395348"
     Region          422..525
                     /region_name="Spectrin"
                     /note="Spectrin repeat; pfam00435"
                     /db_xref="CDD:395348"
     Region          530..742
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            636..641
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          641..848
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            742..747
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          745..954
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            847..852
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          955..1168
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1060..1065
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1170..1379
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1273..1278
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1385..1475
                     /region_name="SPEC"
                     /note="Spectrin repeats; smart00150"
                     /db_xref="CDD:197544"
     Region          1485..1690
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1583..1588
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1691..1901
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1796..1801
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1798..2005
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1902..1907
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          2013..>2070
                     /region_name="Spectrin"
                     /note="Spectrin repeat; pfam00435"
                     /db_xref="CDD:395348"
     Region          2181..2286
                     /region_name="PH_beta_spectrin"
                     /note="Beta-spectrin pleckstrin homology (PH) domain;
                     cd10571"
                     /db_xref="CDD:269975"
     Site            order(2188,2201..2203,2249)
                     /site_type="other"
                     /note="non-cannonical phosphoinositide binding site
                     [chemical binding]"
                     /db_xref="CDD:269975"
     CDS             1..2328
                     /gene="SPTB"
                     /gene_synonym="EL3; HS2; HSPTB1; SPH2"
                     /coded_by="XM_024449699.2:409..7395"
                     /db_xref="GeneID:6710"
                     /db_xref="HGNC:HGNC:11274"
                     /db_xref="MIM:182870"
ORIGIN      
        1 mtsatefenv gnqppysrin arwdapddel dndnssarlf ersrikalad erevvqkktf
       61 tkwvnshlar vscritdlyk dlrdgrmlik llevlsgeml pkptkgkmri hclenvdkal
      121 qflkeqrvhl enmgshdivd gnhrlvlgli wtiilrfqiq divvqtqegr etrsakdall
      181 lwcqmktagy phvnvtnfts swkdglafna lihkhrpdli dfdklkdsna rhnlehafnv
      241 aerqlgiipl ldpedvften pdeksiityv vafyhyfskm kvlavegkrv gkvidhaiet
      301 ekmiekysgl asdlltwieq titvlnsrkf ansltgvqqq lqafstyrtv ekppkfqekg
      361 nlevllftiq srmrannqkv ytphdgklvs dinrawesle eaeyrrelal rnelirqekl
      421 eqlarrfdrk aamretwlse nqrlvaqdnf gydlaaveaa kkkheaietd taayeervra
      481 ledlaqelek enyhdqkrit arkdnilrlw sylqellqsr rqrlettlal qklfqdmlhs
      541 idwmdeikah llsaefgkhl levedllqkh klmeadiaiq gdkvkaitaa tlkftegkgy
      601 qpcdpqviqd rishleqcfe elsnmaagrk aqleqskrlw kffwemdeae swikekeqiy
      661 ssldygkdlt svlilqrkhk afedelrgld ahleqifqea hgmvarkqfg hpqiearike
      721 vsaqwdqlkd laafckknlq daenffqfqg daddlkawlq dahrllsged vgqdegatra
      781 lgkkhkdfle eleesrgvme hleqqaqgfp eefrdspdvt hrlqalrely qqvvaqadlr
      841 qqrlqealdl ytvfgetdac elwmgekekw laemempdtl edlevvqhrf dildqemktl
      901 mtqidgvnla anslvesghp rsrevkqyqd hlntrwqafq tlvserreav dsalrvhnyc
      961 vdceetskwi tdktkvvest kdlgrdlagi iaiqrklsgl erdvaaiqar vdaleresqq
     1021 lmdshpeqke digqrqkhle elwqglqqsl qgqedllgev sqlqaflqdl ddfqawlsit
     1081 qkavasedmp eslpeaeqll qqhagikdei dghqdsyqrv kesgekviqg qtdpeylllg
     1141 qrlegldtgw nalgrmwesr shtlaqclgf qefqkdakqa eailsnqeyt lahleppdsl
     1201 eaaeagirkf edflgsmenn rdkvlspvds gnklvaegnl ysdkikekvq liedrhrknn
     1261 ekaqeasvll rdnlelqnfl qncqeltlwi ndklltsqdv sydearnlhn kwlkhqafva
     1321 elashegwle nidaegkqlm dekpqftalv sqklealhrl wdelqattke ktqhlsaars
     1381 sdlrlqthad lnkwisamed qlrsddpgkd ltsvnrmlak lkrvedqvnv rkeelgelfa
     1441 qvpsmgeegg dadlsiekrf ldlleplgrr kkqlessrak lqisrdlede tlwveerlpl
     1501 aqsadygtnl qtvqlfmkkn qtlqneilgh tprvedvlqr gqqlveaaei dcqdleerlg
     1561 hlqsswdrlr eaaagrlqrl rdaneaqqyy ldadeaeawi geqelyvisd eipkdeegai
     1621 vmlkrhlrqq ravedygrni kqlasraqgl lsaghpegeq iirlqgqvdk hyaglkdvae
     1681 erkrklenmy hlfqlkretd dleqwiseke lvasspemgq dfdhvtllrd kfrdfaretg
     1741 aigqervdnv nafierlida ghseaatiae wkdglnemwa dllelidtrm qllaasydlh
     1801 ryfytgaeil glidekhrel pedvgldast aesfhrvhta ferelhllgv qvqqfqdvat
     1861 rlqtayagek aeaiqnkeqe vsaawqalld acagrrtqlv dtadkfrffs mardllswme
     1921 siirqietqe rprdvssvel lmkyhqgina eietrsknfs aclelgesll qrqhqaseei
     1981 reklqqvmsr rkemnekwea rwerlrmlle vcqfsrdasv aeawliaqep ylasgdfght
     2041 vdsveklikr heafekstas waerfaalek pttlelkerq iaerpaeetg pqeeegetag
     2101 eapvshhaat ertspgeeeg twpqnlqqpp ppgqhkdgqk stgderptte plfkvldtpl
     2161 segdepatlp aprdhgqsvq megylgrkhd legpnkkasn rswnnlycvl rnseltfykd
     2221 aknlalgmpy hgeeplalrh aiceiaanyk kkkhvfklrl sngsewlfhg kdeeemlswl
     2281 qgvstaines qsirvkaqsl plpslsgpda slgkkdkekr fsffpkkk
//
LOCUS       XP_016877101            2328 aa            linear   PRI 05-AUG-2025
DEFINITION  spectrin beta chain, erythrocytic isoform X1 [Homo sapiens].
ACCESSION   XP_016877101
VERSION     XP_016877101.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021612.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2328
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2328
                     /product="spectrin beta chain, erythrocytic isoform X1"
                     /calculated_mol_wt=267696
     Region          25..156
                     /region_name="CH_SPTBN2_rpt1"
                     /note="first calponin homology (CH) domain found in
                     spectrin beta chain, non-erythrocytic 2 (SPTBN2) and
                     similar proteins; cd21317"
                     /db_xref="CDD:409166"
     Site            order(37..38,41,44..45,48..49,52..53,56,110,113..114,117,
                     124,129..137,144..145,147..148,151..152,155..156)
                     /site_type="other"
                     /note="actin binding site [polypeptide binding]"
                     /db_xref="CDD:409166"
     Region          170..281
                     /region_name="CH_SPTB_rpt2"
                     /note="second calponin homology (CH) domain found in
                     spectrin beta chain, erythrocytic (SPTB) and similar
                     proteins; cd21319"
                     /db_xref="CDD:409168"
     Site            order(175,179,229,231..232,235,242,247..255,264..265,
                     267..268,271..272,275)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409168"
     Region          302..412
                     /region_name="Spectrin"
                     /note="Spectrin repeat; pfam00435"
                     /db_xref="CDD:395348"
     Region          422..525
                     /region_name="Spectrin"
                     /note="Spectrin repeat; pfam00435"
                     /db_xref="CDD:395348"
     Region          530..742
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            636..641
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          641..848
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            742..747
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          745..954
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            847..852
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          955..1168
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1060..1065
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1170..1379
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1273..1278
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1385..1475
                     /region_name="SPEC"
                     /note="Spectrin repeats; smart00150"
                     /db_xref="CDD:197544"
     Region          1485..1690
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1583..1588
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1691..1901
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1796..1801
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1798..2005
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1902..1907
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          2013..>2070
                     /region_name="Spectrin"
                     /note="Spectrin repeat; pfam00435"
                     /db_xref="CDD:395348"
     Region          2181..2286
                     /region_name="PH_beta_spectrin"
                     /note="Beta-spectrin pleckstrin homology (PH) domain;
                     cd10571"
                     /db_xref="CDD:269975"
     Site            order(2188,2201..2203,2249)
                     /site_type="other"
                     /note="non-cannonical phosphoinositide binding site
                     [chemical binding]"
                     /db_xref="CDD:269975"
     CDS             1..2328
                     /gene="SPTB"
                     /gene_synonym="EL3; HS2; HSPTB1; SPH2"
                     /coded_by="XM_017021612.3:285..7271"
                     /db_xref="GeneID:6710"
                     /db_xref="HGNC:HGNC:11274"
                     /db_xref="MIM:182870"
ORIGIN      
        1 mtsatefenv gnqppysrin arwdapddel dndnssarlf ersrikalad erevvqkktf
       61 tkwvnshlar vscritdlyk dlrdgrmlik llevlsgeml pkptkgkmri hclenvdkal
      121 qflkeqrvhl enmgshdivd gnhrlvlgli wtiilrfqiq divvqtqegr etrsakdall
      181 lwcqmktagy phvnvtnfts swkdglafna lihkhrpdli dfdklkdsna rhnlehafnv
      241 aerqlgiipl ldpedvften pdeksiityv vafyhyfskm kvlavegkrv gkvidhaiet
      301 ekmiekysgl asdlltwieq titvlnsrkf ansltgvqqq lqafstyrtv ekppkfqekg
      361 nlevllftiq srmrannqkv ytphdgklvs dinrawesle eaeyrrelal rnelirqekl
      421 eqlarrfdrk aamretwlse nqrlvaqdnf gydlaaveaa kkkheaietd taayeervra
      481 ledlaqelek enyhdqkrit arkdnilrlw sylqellqsr rqrlettlal qklfqdmlhs
      541 idwmdeikah llsaefgkhl levedllqkh klmeadiaiq gdkvkaitaa tlkftegkgy
      601 qpcdpqviqd rishleqcfe elsnmaagrk aqleqskrlw kffwemdeae swikekeqiy
      661 ssldygkdlt svlilqrkhk afedelrgld ahleqifqea hgmvarkqfg hpqiearike
      721 vsaqwdqlkd laafckknlq daenffqfqg daddlkawlq dahrllsged vgqdegatra
      781 lgkkhkdfle eleesrgvme hleqqaqgfp eefrdspdvt hrlqalrely qqvvaqadlr
      841 qqrlqealdl ytvfgetdac elwmgekekw laemempdtl edlevvqhrf dildqemktl
      901 mtqidgvnla anslvesghp rsrevkqyqd hlntrwqafq tlvserreav dsalrvhnyc
      961 vdceetskwi tdktkvvest kdlgrdlagi iaiqrklsgl erdvaaiqar vdaleresqq
     1021 lmdshpeqke digqrqkhle elwqglqqsl qgqedllgev sqlqaflqdl ddfqawlsit
     1081 qkavasedmp eslpeaeqll qqhagikdei dghqdsyqrv kesgekviqg qtdpeylllg
     1141 qrlegldtgw nalgrmwesr shtlaqclgf qefqkdakqa eailsnqeyt lahleppdsl
     1201 eaaeagirkf edflgsmenn rdkvlspvds gnklvaegnl ysdkikekvq liedrhrknn
     1261 ekaqeasvll rdnlelqnfl qncqeltlwi ndklltsqdv sydearnlhn kwlkhqafva
     1321 elashegwle nidaegkqlm dekpqftalv sqklealhrl wdelqattke ktqhlsaars
     1381 sdlrlqthad lnkwisamed qlrsddpgkd ltsvnrmlak lkrvedqvnv rkeelgelfa
     1441 qvpsmgeegg dadlsiekrf ldlleplgrr kkqlessrak lqisrdlede tlwveerlpl
     1501 aqsadygtnl qtvqlfmkkn qtlqneilgh tprvedvlqr gqqlveaaei dcqdleerlg
     1561 hlqsswdrlr eaaagrlqrl rdaneaqqyy ldadeaeawi geqelyvisd eipkdeegai
     1621 vmlkrhlrqq ravedygrni kqlasraqgl lsaghpegeq iirlqgqvdk hyaglkdvae
     1681 erkrklenmy hlfqlkretd dleqwiseke lvasspemgq dfdhvtllrd kfrdfaretg
     1741 aigqervdnv nafierlida ghseaatiae wkdglnemwa dllelidtrm qllaasydlh
     1801 ryfytgaeil glidekhrel pedvgldast aesfhrvhta ferelhllgv qvqqfqdvat
     1861 rlqtayagek aeaiqnkeqe vsaawqalld acagrrtqlv dtadkfrffs mardllswme
     1921 siirqietqe rprdvssvel lmkyhqgina eietrsknfs aclelgesll qrqhqaseei
     1981 reklqqvmsr rkemnekwea rwerlrmlle vcqfsrdasv aeawliaqep ylasgdfght
     2041 vdsveklikr heafekstas waerfaalek pttlelkerq iaerpaeetg pqeeegetag
     2101 eapvshhaat ertspgeeeg twpqnlqqpp ppgqhkdgqk stgderptte plfkvldtpl
     2161 segdepatlp aprdhgqsvq megylgrkhd legpnkkasn rswnnlycvl rnseltfykd
     2221 aknlalgmpy hgeeplalrh aiceiaanyk kkkhvfklrl sngsewlfhg kdeeemlswl
     2281 qgvstaines qsirvkaqsl plpslsgpda slgkkdkekr fsffpkkk
//
LOCUS       XP_011535407            1554 aa            linear   PRI 05-AUG-2025
DEFINITION  spectrin beta chain, erythrocytic isoform X2 [Homo sapiens].
ACCESSION   XP_011535407
VERSION     XP_011535407.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537105.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1554
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1554
                     /product="spectrin beta chain, erythrocytic isoform X2"
                     /calculated_mol_wt=178845
     Region          25..156
                     /region_name="CH_SPTBN2_rpt1"
                     /note="first calponin homology (CH) domain found in
                     spectrin beta chain, non-erythrocytic 2 (SPTBN2) and
                     similar proteins; cd21317"
                     /db_xref="CDD:409166"
     Site            order(37..38,41,44..45,48..49,52..53,56,110,113..114,117,
                     124,129..137,144..145,147..148,151..152,155..156)
                     /site_type="other"
                     /note="actin binding site [polypeptide binding]"
                     /db_xref="CDD:409166"
     Region          170..281
                     /region_name="CH_SPTB_rpt2"
                     /note="second calponin homology (CH) domain found in
                     spectrin beta chain, erythrocytic (SPTB) and similar
                     proteins; cd21319"
                     /db_xref="CDD:409168"
     Site            order(175,179,229,231..232,235,242,247..255,264..265,
                     267..268,271..272,275)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409168"
     Region          302..412
                     /region_name="Spectrin"
                     /note="Spectrin repeat; pfam00435"
                     /db_xref="CDD:395348"
     Region          422..525
                     /region_name="Spectrin"
                     /note="Spectrin repeat; pfam00435"
                     /db_xref="CDD:395348"
     Region          530..742
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            636..641
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          641..848
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            742..747
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          745..954
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            847..852
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          955..1168
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1060..1065
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1170..1379
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1273..1278
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1385..>1522
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1477..1482
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     CDS             1..1554
                     /gene="SPTB"
                     /gene_synonym="EL3; HS2; HSPTB1; SPH2"
                     /coded_by="XM_011537105.4:168..4832"
                     /db_xref="GeneID:6710"
                     /db_xref="HGNC:HGNC:11274"
                     /db_xref="MIM:182870"
ORIGIN      
        1 mtsatefenv gnqppysrin arwdapddel dndnssarlf ersrikalad erevvqkktf
       61 tkwvnshlar vscritdlyk dlrdgrmlik llevlsgeml pkptkgkmri hclenvdkal
      121 qflkeqrvhl enmgshdivd gnhrlvlgli wtiilrfqiq divvqtqegr etrsakdall
      181 lwcqmktagy phvnvtnfts swkdglafna lihkhrpdli dfdklkdsna rhnlehafnv
      241 aerqlgiipl ldpedvften pdeksiityv vafyhyfskm kvlavegkrv gkvidhaiet
      301 ekmiekysgl asdlltwieq titvlnsrkf ansltgvqqq lqafstyrtv ekppkfqekg
      361 nlevllftiq srmrannqkv ytphdgklvs dinrawesle eaeyrrelal rnelirqekl
      421 eqlarrfdrk aamretwlse nqrlvaqdnf gydlaaveaa kkkheaietd taayeervra
      481 ledlaqelek enyhdqkrit arkdnilrlw sylqellqsr rqrlettlal qklfqdmlhs
      541 idwmdeikah llsaefgkhl levedllqkh klmeadiaiq gdkvkaitaa tlkftegkgy
      601 qpcdpqviqd rishleqcfe elsnmaagrk aqleqskrlw kffwemdeae swikekeqiy
      661 ssldygkdlt svlilqrkhk afedelrgld ahleqifqea hgmvarkqfg hpqiearike
      721 vsaqwdqlkd laafckknlq daenffqfqg daddlkawlq dahrllsged vgqdegatra
      781 lgkkhkdfle eleesrgvme hleqqaqgfp eefrdspdvt hrlqalrely qqvvaqadlr
      841 qqrlqealdl ytvfgetdac elwmgekekw laemempdtl edlevvqhrf dildqemktl
      901 mtqidgvnla anslvesghp rsrevkqyqd hlntrwqafq tlvserreav dsalrvhnyc
      961 vdceetskwi tdktkvvest kdlgrdlagi iaiqrklsgl erdvaaiqar vdaleresqq
     1021 lmdshpeqke digqrqkhle elwqglqqsl qgqedllgev sqlqaflqdl ddfqawlsit
     1081 qkavasedmp eslpeaeqll qqhagikdei dghqdsyqrv kesgekviqg qtdpeylllg
     1141 qrlegldtgw nalgrmwesr shtlaqclgf qefqkdakqa eailsnqeyt lahleppdsl
     1201 eaaeagirkf edflgsmenn rdkvlspvds gnklvaegnl ysdkikekvq liedrhrknn
     1261 ekaqeasvll rdnlelqnfl qncqeltlwi ndklltsqdv sydearnlhn kwlkhqafva
     1321 elashegwle nidaegkqlm dekpqftalv sqklealhrl wdelqattke ktqhlsaars
     1381 sdlrlqthad lnkwisamed qlrsddpgkd ltsvnrmlak lkrvedqvnv rkeelgelfa
     1441 qvpsmgeegg dadlsiekrf ldlleplgrr kkqlessrak lqisrdlede tlwveerlpl
     1501 aqsadygtnl qtvqlfmkkn qesssaeaqe drgqsraqaa rsggavfnsg sate
//
LOCUS       XP_047287683             400 aa            linear   PRI 05-AUG-2025
DEFINITION  signal recognition particle subunit SRP54 isoform X2 [Homo
            sapiens].
ACCESSION   XP_047287683
VERSION     XP_047287683.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431727.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..400
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..400
                     /product="signal recognition particle subunit SRP54
                     isoform X2"
                     /calculated_mol_wt=44095
     Region          <1..326
                     /region_name="SRP54_euk"
                     /note="signal recognition particle protein SRP54;
                     TIGR01425"
                     /db_xref="CDD:273615"
     CDS             1..400
                     /gene="SRP54"
                     /gene_synonym="SCN8"
                     /coded_by="XM_047431727.1:152..1354"
                     /db_xref="GeneID:6729"
                     /db_xref="HGNC:HGNC:11301"
                     /db_xref="MIM:604857"
ORIGIN      
        1 mfvglqgsgk tttcsklayy yqrkgwktcl icadtfraga fdqlkqnatk aripfygsyt
       61 emdpviiase gvekfknenf eiiivdtsgr hkqedslfee mlqvanaiqp dnivyvmdas
      121 igqaceaqak afkdkvdvas vivtkldgha kgggalsava atkspiifig tgehiddfep
      181 fktqpfiskl lgmgdiegli dkvnelkldd nealieklkh gqftlrdmye qfqnimkmgp
      241 fsqilgmipg fgtdfmskgn eqesmarlkk lmtimdsmnd qeldstdgak vfskqpgriq
      301 rvargsgvst rdvqelltqy tkfaqmvkkm ggikglfkgg dmsknvsqsq maklnqqmak
      361 mmdprvlhhm ggmaglqsmm rqfqqgaagn mkgmmgfnnm
//
LOCUS       XP_047287684             354 aa            linear   PRI 05-AUG-2025
DEFINITION  somatostatin receptor type 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047287684
VERSION     XP_047287684.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431728.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..354
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..354
                     /product="somatostatin receptor type 1 isoform X1"
                     /calculated_mol_wt=39337
     Region          22..297
                     /region_name="7tmA_SSTR1"
                     /note="somatostatin receptor type 1, member of the class A
                     family of seven-transmembrane G protein-coupled receptors;
                     cd15970"
                     /db_xref="CDD:320636"
     Region          23..49
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:320636"
     Region          56..82
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320636"
     Site            order(77,80..81,93..98,100..101,104,149,151..155,183,
                     186..188,190..192,194..195,247,250..251,253..254,257,
                     264..265,267..269,272,275..276)
                     /site_type="other"
                     /note="putative peptide ligand binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:320636"
     Region          93..123
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320636"
     Region          135..157
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320636"
     Region          183..212
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320636"
     Region          227..257
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320636"
     Region          265..290
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320636"
     CDS             1..354
                     /gene="SSTR1"
                     /gene_synonym="SRIF-2; SS-1-R; SS1-R; SS1R; SST1"
                     /coded_by="XM_047431728.1:420..1484"
                     /db_xref="GeneID:6751"
                     /db_xref="HGNC:HGNC:11330"
                     /db_xref="MIM:182451"
ORIGIN      
        1 meepgrnasq ngtlsegqgs ailisfiysv vclvglcgns mviyvilrya kmktatniyi
       61 lnlaiadell mlsvpflvts tllrhwpfga llcrlvlsvd avnmftsiyc ltvlsvdryv
      121 avvhpikaar yrrptvakvv nlgvwvlsll vilpivvfsr taansdgtva cnmlmpepaq
      181 rwlvgfvlyt flmgfllpvg aiclcyvlii akmrmvalka gwqqrkrser kitlmvmmvv
      241 mvfvicwmpf yvvqlvnvfa eqddatvsql svilgyansc anpilygfls dnfkrsfqri
      301 lclswmdnaa eepvdyyata lksraysved fqpenlesgg vfrngtctsr ittl
//
LOCUS       XP_011535410             199 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine/tyrosine-interacting protein isoform X1 [Homo
            sapiens].
ACCESSION   XP_011535410
VERSION     XP_011535410.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537108.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..199
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..199
                     /product="serine/threonine/tyrosine-interacting protein
                     isoform X1"
                     /calculated_mol_wt=22494
     Region          1..151
                     /region_name="DSP_STYX"
                     /note="dual specificity phosphatase-like domain of
                     serine/threonine/tyrosine-interacting protein; cd14522"
                     /db_xref="CDD:350372"
     CDS             1..199
                     /gene="STYX"
                     /coded_by="XM_011537108.2:50..649"
                     /db_xref="GeneID:6815"
                     /db_xref="HGNC:HGNC:11447"
                     /db_xref="MIM:615814"
ORIGIN      
        1 mrremqeilp glflgpyssa mksklpvlqk hgithiicir qnieanfikp nfqqlfrylv
       61 ldiadnpven iirffpmtke fidgslqmgg kvlvhgnagi srsaafviay imetfgmkyr
      121 dafayvqerr fcinpnagfv hqlqeyeaiy lakltiqmms plqierslsv hsgttgslkr
      181 theeeddfgt mqvataqng
//
LOCUS       XP_047287687             123 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine/tyrosine-interacting protein isoform X2 [Homo
            sapiens].
ACCESSION   XP_047287687
VERSION     XP_047287687.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431731.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..123
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..123
                     /product="serine/threonine/tyrosine-interacting protein
                     isoform X2"
                     /calculated_mol_wt=13599
     Region          <1..75
                     /region_name="PTP_DSP_cys"
                     /note="cys-based protein tyrosine phosphatase and
                     dual-specificity phosphatase superfamily; cl28904"
                     /db_xref="CDD:475123"
     CDS             1..123
                     /gene="STYX"
                     /coded_by="XM_047431731.1:305..676"
                     /db_xref="GeneID:6815"
                     /db_xref="HGNC:HGNC:11447"
                     /db_xref="MIM:615814"
ORIGIN      
        1 mtkefidgsl qmggkvlvhg nagisrsaaf viayimetfg mkyrdafayv qerrfcinpn
       61 agfvhqlqey eaiylaklti qmmsplqier slsvhsgttg slkrtheeed dfgtmqvata
      121 qng
//
LOCUS       XP_011535411             112 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine/tyrosine-interacting protein isoform X3 [Homo
            sapiens].
ACCESSION   XP_011535411
VERSION     XP_011535411.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537109.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..112
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..112
                     /product="serine/threonine/tyrosine-interacting protein
                     isoform X3"
                     /calculated_mol_wt=12348
     Region          <1..64
                     /region_name="PTP_DSP_cys"
                     /note="cys-based protein tyrosine phosphatase and
                     dual-specificity phosphatase superfamily; cl28904"
                     /db_xref="CDD:475123"
     CDS             1..112
                     /gene="STYX"
                     /coded_by="XM_011537109.3:277..615"
                     /db_xref="GeneID:6815"
                     /db_xref="HGNC:HGNC:11447"
                     /db_xref="MIM:615814"
ORIGIN      
        1 mggkvlvhgn agisrsaafv iayimetfgm kyrdafayvq errfcinpna gfvhqlqeye
       61 aiylakltiq mmsplqiers lsvhsgttgs lkrtheeedd fgtmqvataq ng
//
LOCUS       XP_005268084            2627 aa            linear   PRI 05-AUG-2025
DEFINITION  telomerase protein component 1 isoform X1 [Homo sapiens].
ACCESSION   XP_005268084
VERSION     XP_005268084.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005268027.6
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2627
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2627
                     /product="telomerase protein component 1 isoform X1"
                     /calculated_mol_wt=290360
     Region          1..29
                     /region_name="TEP1_N"
                     /note="TEP1 N-terminal domain; pfam05386"
                     /db_xref="CDD:428450"
     Region          31..59
                     /region_name="TEP1_N"
                     /note="TEP1 N-terminal domain; pfam05386"
                     /db_xref="CDD:428450"
     Region          61..89
                     /region_name="TEP1_N"
                     /note="TEP1 N-terminal domain; pfam05386"
                     /db_xref="CDD:428450"
     Region          91..119
                     /region_name="TEP1_N"
                     /note="TEP1 N-terminal domain; pfam05386"
                     /db_xref="CDD:428450"
     Region          226..676
                     /region_name="TROVE"
                     /note="TROVE domain; pfam05731"
                     /db_xref="CDD:461724"
     Region          687..889
                     /region_name="DUF5920"
                     /note="Domain of unknown function (DUF5920); pfam19334"
                     /db_xref="CDD:466045"
     Region          900..1008
                     /region_name="DUF4062"
                     /note="Domain of unknown function (DUF4062); pfam13271"
                     /db_xref="CDD:463823"
     Region          1162..1337
                     /region_name="NACHT"
                     /note="NACHT domain; pfam05729"
                     /db_xref="CDD:428606"
     Region          <1680..1958
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          1680..1716
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1722..1757
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1762..1801
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1804..1840
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1845..1881
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1849..2268
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          1888..1923
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1972..2013
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2016..2059
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2064..2103
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2111..2145
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2151..2235
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2231..>2391
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          2241..2280
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2283..2307
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2326..2359
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2372..2418
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..2627
                     /gene="TEP1"
                     /gene_synonym="p240; TLP1; TP1; TROVE1; VAULT2"
                     /coded_by="XM_005268027.6:156..8039"
                     /db_xref="GeneID:7011"
                     /db_xref="HGNC:HGNC:11726"
                     /db_xref="MIM:601686"
ORIGIN      
        1 meklhghvsa hpdilslenr clamlpdlqp leklhqhvst hsdilslknq clatlpdlkt
       61 mekphgyvsa hpdilslenq clatlsdlkt mekphghvsa hpdilslenr clatlsslks
      121 tvsasplfqs lqishmtqad lyrvnnsncl lseppswraq hfskgldlst cpialksisa
      181 tetaqeatlg rwfdseekkg aetqmpsysl slgeeeeved lavkltsgds eshpeptdhv
      241 lqekkmalls llcstlvsev nmnntsdptl aaifeicrel allepefilk aslyarqqln
      301 vrnvannila iaaflpacrp hlrryfcaiv qlpsdwiqva elyqslaegd knklvplpac
      361 lrtamtdkfa qfdeyqlaky nprkhrakrh prrpprspgm eppfshrcfp ryigflreeq
      421 rkfekagdtv sekknpprft lkklvqrlhi hkpaqhvqal lgyrypsnlq lfsrsrlpgp
      481 wdssragkrm klsrpetwer elslrgnkas vweeliengk lpfmamlrnl cnllrvgiss
      541 rhhelilqrl qhaksvihsr qfpfrflnah daidaleaql rnqalpfpsn itlmrriltr
      601 neknrprrrf lchlsrqqlr mamripvlye qlkreklrvh karqwkydge mlnryrqale
      661 tavnlsvkhs lpllpgrtvl vyltdanadr lcpksnpqgp plnyalllig mmitraeqvd
      721 vvlcggdtlk tavlkaeegi lktaiklqaq vqefdendgw slntfgkyll slagqrvpvd
      781 rvillgqsmd dgminvakql ywqrvnskcl fvgillrrvq ylstdlnpnd vtlsgctdai
      841 lkfiaehgas hllehvgqmd kifkippppg ktgvqslrpl eedtpsplap vsqqgwrsir
      901 lfisstfrdm hgerdlllrs vlpalqaraa phrislhgid lrwgvteeet rrnrqlevcl
      961 gevenaqlfv gilgsrygyi ppsynlpdhp hfhwaqqyps grsvtemevm qflnrnqrlq
     1021 psaqaliyfr dssflssvpd awksdfvses eeaarrisel ksylsrqkgi tcrrypcewg
     1081 gvaagrpyvg gleefgqlvl qdvwnmiqkl ylqpgalleq pvsipdddlv qatfqqlqkp
     1141 psparprllq dtvqrlmlph grlslvtgqs gqgktaflas lvsalqapdg akvaslvffh
     1201 fsgarpdqgl altllrrlct ylrgqlkepg alpstyrslv welqqrllpk saeslhpgqt
     1261 qvliidgadr lvdqngqlis dwipkklprc vhlvlsvssd aglgetleqs qgahvlalgp
     1321 leasararlv reelalygkr leespfnnqm rlllvkresg rplylrlvtd hlrlftlyeq
     1381 vserlrtlpa tvplllqhil stlekehgpd vlpqaltale vtrsgltvdq lhgvlsvwrt
     1441 lpkgtkswee avaagnsgdp ypmgpfaclv qslrsllgeg plerpgarlc lpdgplrtaa
     1501 krcygkrpgl edtahiliaa qlwktcdada sgtfrscppe algdlpyhll qsgnrgllsk
     1561 fltnlhvvaa hlelglvsrl leahalyass vpkeeqklpe advavfrtfl rqqasilsqy
     1621 prllpqqaan qpldsplchq asllsrrwhl qhtlrwlnkp rtmknqqsss lslavssspt
     1681 avafstngqr aavgtangtv ylldlrtwqe eksvvsgcdg isaclflsdd tlfltafdgl
     1741 lelwdlqhgc rvlqtkahqy qitgcclspd crllatvclg gclklwdtvr gqlafqhtyp
     1801 kslncvafhp egqviatgsw agsisffqvd glkvtkdlga pgasirtlaf nvpggvvavg
     1861 rldsmvelwa wregarlaaf pahhgfvaaa lflhagcqll tagedgkvqv wsgslgrprg
     1921 hlgslslspa lsvalspdgd rvavgyradg iriykissgs qgaqgqaldv avsalawlsp
     1981 kvlvsgaedg slqgwalkec slqslwllsr fqkpvlglat sqellasase dftvqlwprq
     2041 lltrphkaed fpcgtelrgh egpvsccsfs tdggslatgg rdrsllcwdv rtpktpvlih
     2101 sfpachrdwv tgcawtkdnl liscssdgsv glwdpesgqr lgqflghqsa vsavaaveeh
     2161 vvsvsrdgtl kvwdhqgvel tsipahsgpi shcaaamepr aagqpgsell vvtvgldgat
     2221 rlwhpllvcq thtllghsgp vraaavsets glmltasedg svrlwqvpke addtciprss
     2281 aavtavawap dgsmavsgnq agelilwqea kavataqapg higaliwssa htffvlsade
     2341 kisewqvklr kgsapgnlsl hlnrilqedl gvltsldwap dghflilaka dlkllcmkpg
     2401 dapseiwssy tenpmilsth keygifvlqp kdpgvlsflr qkesgefeer lnfdinlenp
     2461 srtlisitqa kpesessflc assdgilwnl akcspegewt tgnmwqkkan tpetqtpgtd
     2521 pstcresdas mdsdasmdse ptphlktrqr rkihsgsvta lhvlpellvt askdrdvklw
     2581 erpsmqllgl frcegsvscl epwlganstl qlavgdvqgn vyflnwe
//
LOCUS       XP_047287689            2423 aa            linear   PRI 05-AUG-2025
DEFINITION  telomerase protein component 1 isoform X2 [Homo sapiens].
ACCESSION   XP_047287689
VERSION     XP_047287689.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431733.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2423
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2423
                     /product="telomerase protein component 1 isoform X2"
                     /calculated_mol_wt=267861
     Region          22..472
                     /region_name="TROVE"
                     /note="TROVE domain; pfam05731"
                     /db_xref="CDD:461724"
     Region          483..685
                     /region_name="DUF5920"
                     /note="Domain of unknown function (DUF5920); pfam19334"
                     /db_xref="CDD:466045"
     Region          696..804
                     /region_name="DUF4062"
                     /note="Domain of unknown function (DUF4062); pfam13271"
                     /db_xref="CDD:463823"
     Region          958..1133
                     /region_name="NACHT"
                     /note="NACHT domain; pfam05729"
                     /db_xref="CDD:428606"
     Region          <1476..1754
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          1476..1512
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1518..1553
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1558..1597
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1600..1636
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1641..1677
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1645..2064
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          1684..1719
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1768..1809
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1812..1855
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1860..1899
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1907..1941
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1947..2031
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2027..>2187
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          2037..2076
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2079..2103
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2122..2155
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2168..2214
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..2423
                     /gene="TEP1"
                     /gene_synonym="p240; TLP1; TP1; TROVE1; VAULT2"
                     /coded_by="XM_047431733.1:1329..8600"
                     /db_xref="GeneID:7011"
                     /db_xref="HGNC:HGNC:11726"
                     /db_xref="MIM:601686"
ORIGIN      
        1 mpsyslslge eeevedlavk ltsgdseshp eptdhvlqek kmallsllcs tlvsevnmnn
       61 tsdptlaaif eicrelalle pefilkasly arqqlnvrnv annilaiaaf lpacrphlrr
      121 yfcaivqlps dwiqvaelyq slaegdknkl vplpaclrta mtdkfaqfde yqlakynprk
      181 hrakrhprrp prspgmeppf shrcfpryig flreeqrkfe kagdtvsekk npprftlkkl
      241 vqrlhihkpa qhvqallgyr ypsnlqlfsr srlpgpwdss ragkrmklsr petwerelsl
      301 rgnkasvwee liengklpfm amlrnlcnll rvgissrhhe lilqrlqhak svihsrqfpf
      361 rflnahdaid aleaqlrnqa lpfpsnitlm rriltrnekn rprrrflchl srqqlrmamr
      421 ipvlyeqlkr eklrvhkarq wkydgemlnr yrqaletavn lsvkhslpll pgrtvlvylt
      481 danadrlcpk snpqgpplny allligmmit raeqvdvvlc ggdtlktavl kaeegilkta
      541 iklqaqvqef dendgwslnt fgkyllslag qrvpvdrvil lgqsmddgmi nvakqlywqr
      601 vnskclfvgi llrrvqylst dlnpndvtls gctdailkfi aehgashlle hvgqmdkifk
      661 ippppgktgv qslrpleedt psplapvsqq gwrsirlfis stfrdmhger dlllrsvlpa
      721 lqaraaphri slhgidlrwg vteeetrrnr qlevclgeve naqlfvgilg srygyippsy
      781 nlpdhphfhw aqqypsgrsv temevmqfln rnqrlqpsaq aliyfrdssf lssvpdawks
      841 dfvseseeaa rriselksyl srqkgitcrr ypcewggvaa grpyvgglee fgqlvlqdvw
      901 nmiqklylqp galleqpvsi pdddlvqatf qqlqkppspa rprllqdtvq rlmlphgrls
      961 lvtgqsgqgk taflaslvsa lqapdgakva slvffhfsga rpdqglaltl lrrlctylrg
     1021 qlkepgalps tyrslvwelq qrllpksaes lhpgqtqvli idgadrlvdq ngqlisdwip
     1081 kklprcvhlv lsvssdaglg etleqsqgah vlalgpleas ararlvreel alygkrlees
     1141 pfnnqmrlll vkresgrply lrlvtdhlrl ftlyeqvser lrtlpatvpl llqhilstle
     1201 kehgpdvlpq altalevtrs gltvdqlhgv lsvwrtlpkg tksweeavaa gnsgdpypmg
     1261 pfaclvqslr sllgegpler pgarlclpdg plrtaakrcy gkrpgledta hiliaaqlwk
     1321 tcdadasgtf rscppealgd lpyhllqsgn rgllskfltn lhvvaahlel glvsrlleah
     1381 alyassvpke eqklpeadva vfrtflrqqa silsqyprll pqqaanqpld splchqasll
     1441 srrwhlqhtl rwlnkprtmk nqqssslsla vsssptavaf stngqraavg tangtvylld
     1501 lrtwqeeksv vsgcdgisac lflsddtlfl tafdgllelw dlqhgcrvlq tkahqyqitg
     1561 cclspdcrll atvclggclk lwdtvrgqla fqhtypksln cvafhpegqv iatgswagsi
     1621 sffqvdglkv tkdlgapgas irtlafnvpg gvvavgrlds mvelwawreg arlaafpahh
     1681 gfvaaalflh agcqlltage dgkvqvwsgs lgrprghlgs lslspalsva lspdgdrvav
     1741 gyradgiriy kissgsqgaq gqaldvavsa lawlspkvlv sgaedgslqg walkecslqs
     1801 lwllsrfqkp vlglatsqel lasasedftv qlwprqlltr phkaedfpcg telrghegpv
     1861 sccsfstdgg slatggrdrs llcwdvrtpk tpvlihsfpa chrdwvtgca wtkdnllisc
     1921 ssdgsvglwd pesgqrlgqf lghqsavsav aaveehvvsv srdgtlkvwd hqgveltsip
     1981 ahsgpishca aamepraagq pgsellvvtv gldgatrlwh pllvcqthtl lghsgpvraa
     2041 avsetsglml tasedgsvrl wqvpkeaddt ciprssaavt avawapdgsm avsgnqagel
     2101 ilwqeakava taqapghiga liwssahtff vlsadekise wqvklrkgsa pgnlslhlnr
     2161 ilqedlgvlt sldwapdghf lilakadlkl lcmkpgdaps eiwssytenp milsthkeyg
     2221 ifvlqpkdpg vlsflrqkes gefeerlnfd inlenpsrtl isitqakpes essflcassd
     2281 gilwnlakcs pegewttgnm wqkkantpet qtpgtdpstc resdasmdsd asmdseptph
     2341 lktrqrrkih sgsvtalhvl pellvtaskd rdvklwerps mqllglfrce gsvsclepwl
     2401 ganstlqlav gdvqgnvyfl nwe
//
LOCUS       XP_047287690            2338 aa            linear   PRI 05-AUG-2025
DEFINITION  telomerase protein component 1 isoform X3 [Homo sapiens].
ACCESSION   XP_047287690
VERSION     XP_047287690.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431734.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2338
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2338
                     /product="telomerase protein component 1 isoform X3"
                     /calculated_mol_wt=257941
     Region          1..29
                     /region_name="TEP1_N"
                     /note="TEP1 N-terminal domain; pfam05386"
                     /db_xref="CDD:428450"
     Region          31..59
                     /region_name="TEP1_N"
                     /note="TEP1 N-terminal domain; pfam05386"
                     /db_xref="CDD:428450"
     Region          61..89
                     /region_name="TEP1_N"
                     /note="TEP1 N-terminal domain; pfam05386"
                     /db_xref="CDD:428450"
     Region          91..119
                     /region_name="TEP1_N"
                     /note="TEP1 N-terminal domain; pfam05386"
                     /db_xref="CDD:428450"
     Region          226..676
                     /region_name="TROVE"
                     /note="TROVE domain; pfam05731"
                     /db_xref="CDD:461724"
     Region          687..889
                     /region_name="DUF5920"
                     /note="Domain of unknown function (DUF5920); pfam19334"
                     /db_xref="CDD:466045"
     Region          900..1008
                     /region_name="DUF4062"
                     /note="Domain of unknown function (DUF4062); pfam13271"
                     /db_xref="CDD:463823"
     Region          1162..1337
                     /region_name="NACHT"
                     /note="NACHT domain; pfam05729"
                     /db_xref="CDD:428606"
     Region          <1680..1958
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          1680..1716
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1722..1757
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1762..1801
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1804..1840
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1845..1881
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1849..2268
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          1888..1923
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1972..2013
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2016..2059
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2064..2105
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2111..2146
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2151..2183
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2191..2234
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2231..>2307
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          2241..2275
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2283..2318
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..2338
                     /gene="TEP1"
                     /gene_synonym="p240; TLP1; TP1; TROVE1; VAULT2"
                     /coded_by="XM_047431734.1:156..7172"
                     /db_xref="GeneID:7011"
                     /db_xref="HGNC:HGNC:11726"
                     /db_xref="MIM:601686"
ORIGIN      
        1 meklhghvsa hpdilslenr clamlpdlqp leklhqhvst hsdilslknq clatlpdlkt
       61 mekphgyvsa hpdilslenq clatlsdlkt mekphghvsa hpdilslenr clatlsslks
      121 tvsasplfqs lqishmtqad lyrvnnsncl lseppswraq hfskgldlst cpialksisa
      181 tetaqeatlg rwfdseekkg aetqmpsysl slgeeeeved lavkltsgds eshpeptdhv
      241 lqekkmalls llcstlvsev nmnntsdptl aaifeicrel allepefilk aslyarqqln
      301 vrnvannila iaaflpacrp hlrryfcaiv qlpsdwiqva elyqslaegd knklvplpac
      361 lrtamtdkfa qfdeyqlaky nprkhrakrh prrpprspgm eppfshrcfp ryigflreeq
      421 rkfekagdtv sekknpprft lkklvqrlhi hkpaqhvqal lgyrypsnlq lfsrsrlpgp
      481 wdssragkrm klsrpetwer elslrgnkas vweeliengk lpfmamlrnl cnllrvgiss
      541 rhhelilqrl qhaksvihsr qfpfrflnah daidaleaql rnqalpfpsn itlmrriltr
      601 neknrprrrf lchlsrqqlr mamripvlye qlkreklrvh karqwkydge mlnryrqale
      661 tavnlsvkhs lpllpgrtvl vyltdanadr lcpksnpqgp plnyalllig mmitraeqvd
      721 vvlcggdtlk tavlkaeegi lktaiklqaq vqefdendgw slntfgkyll slagqrvpvd
      781 rvillgqsmd dgminvakql ywqrvnskcl fvgillrrvq ylstdlnpnd vtlsgctdai
      841 lkfiaehgas hllehvgqmd kifkippppg ktgvqslrpl eedtpsplap vsqqgwrsir
      901 lfisstfrdm hgerdlllrs vlpalqaraa phrislhgid lrwgvteeet rrnrqlevcl
      961 gevenaqlfv gilgsrygyi ppsynlpdhp hfhwaqqyps grsvtemevm qflnrnqrlq
     1021 psaqaliyfr dssflssvpd awksdfvses eeaarrisel ksylsrqkgi tcrrypcewg
     1081 gvaagrpyvg gleefgqlvl qdvwnmiqkl ylqpgalleq pvsipdddlv qatfqqlqkp
     1141 psparprllq dtvqrlmlph grlslvtgqs gqgktaflas lvsalqapdg akvaslvffh
     1201 fsgarpdqgl altllrrlct ylrgqlkepg alpstyrslv welqqrllpk saeslhpgqt
     1261 qvliidgadr lvdqngqlis dwipkklprc vhlvlsvssd aglgetleqs qgahvlalgp
     1321 leasararlv reelalygkr leespfnnqm rlllvkresg rplylrlvtd hlrlftlyeq
     1381 vserlrtlpa tvplllqhil stlekehgpd vlpqaltale vtrsgltvdq lhgvlsvwrt
     1441 lpkgtkswee avaagnsgdp ypmgpfaclv qslrsllgeg plerpgarlc lpdgplrtaa
     1501 krcygkrpgl edtahiliaa qlwktcdada sgtfrscppe algdlpyhll qsgnrgllsk
     1561 fltnlhvvaa hlelglvsrl leahalyass vpkeeqklpe advavfrtfl rqqasilsqy
     1621 prllpqqaan qpldsplchq asllsrrwhl qhtlrwlnkp rtmknqqsss lslavssspt
     1681 avafstngqr aavgtangtv ylldlrtwqe eksvvsgcdg isaclflsdd tlfltafdgl
     1741 lelwdlqhgc rvlqtkahqy qitgcclspd crllatvclg gclklwdtvr gqlafqhtyp
     1801 kslncvafhp egqviatgsw agsisffqvd glkvtkdlga pgasirtlaf nvpggvvavg
     1861 rldsmvelwa wregarlaaf pahhgfvaaa lflhagcqll tagedgkvqv wsgslgrprg
     1921 hlgslslspa lsvalspdgd rvavgyradg iriykissgs qgaqgqaldv avsalawlsp
     1981 kvlvsgaedg slqgwalkec slqslwllsr fqkpvlglat sqellasase dftvqlwprq
     2041 lltrphkaed fpcgtelrgh egpvsccsfs tdggslatgg rdrsllcwdv rtpktpvlih
     2101 sfpachrdwv tgcawtkdnl liscssdgsv glwdpesgqr lgqflghqsa vsavaaveeh
     2161 vvsvsrdgtl kvwdhqgvel tsipahsgpi shcaaamepr aagqpgsell vvtvgldgat
     2221 rlwhpllvcq thtllghsgp vraaavsets glmltasedg svrlwqvpke addtciprss
     2281 aavtavawap dgsmavsgnq agelilwqea kavataqssp epnstgglrg adksglgs
//
LOCUS       XP_011535412            2104 aa            linear   PRI 05-AUG-2025
DEFINITION  telomerase protein component 1 isoform X4 [Homo sapiens].
ACCESSION   XP_011535412
VERSION     XP_011535412.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537110.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2104
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2104
                     /product="telomerase protein component 1 isoform X4"
                     /calculated_mol_wt=231209
     Region          <1..153
                     /region_name="TROVE"
                     /note="TROVE domain; pfam05731"
                     /db_xref="CDD:461724"
     Region          164..366
                     /region_name="DUF5920"
                     /note="Domain of unknown function (DUF5920); pfam19334"
                     /db_xref="CDD:466045"
     Region          377..485
                     /region_name="DUF4062"
                     /note="Domain of unknown function (DUF4062); pfam13271"
                     /db_xref="CDD:463823"
     Region          639..814
                     /region_name="NACHT"
                     /note="NACHT domain; pfam05729"
                     /db_xref="CDD:428606"
     Region          <1157..1435
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          1157..1193
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1199..1234
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1239..1278
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1281..1317
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1322..1358
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1326..1745
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          1365..1400
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1449..1490
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1493..1536
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1541..1580
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1588..1622
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1628..1712
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1708..>1868
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          1718..1757
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1760..1784
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1803..1836
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1849..1895
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..2104
                     /gene="TEP1"
                     /gene_synonym="p240; TLP1; TP1; TROVE1; VAULT2"
                     /coded_by="XM_011537110.3:104..6418"
                     /db_xref="GeneID:7011"
                     /db_xref="HGNC:HGNC:11726"
                     /db_xref="MIM:601686"
ORIGIN      
        1 mamlrnlcnl lrvgissrhh elilqrlqha ksvihsrqfp frflnahdai daleaqlrnq
       61 alpfpsnitl mrriltrnek nrprrrflch lsrqqlrmam ripvlyeqlk reklrvhkar
      121 qwkydgemln ryrqaletav nlsvkhslpl lpgrtvlvyl tdanadrlcp ksnpqgppln
      181 yallligmmi traeqvdvvl cggdtlktav lkaeegilkt aiklqaqvqe fdendgwsln
      241 tfgkyllsla gqrvpvdrvi llgqsmddgm invakqlywq rvnskclfvg illrrvqyls
      301 tdlnpndvtl sgctdailkf iaehgashll ehvgqmdkif kippppgktg vqslrpleed
      361 tpsplapvsq qgwrsirlfi sstfrdmhge rdlllrsvlp alqaraaphr islhgidlrw
      421 gvteeetrrn rqlevclgev enaqlfvgil gsrygyipps ynlpdhphfh waqqypsgrs
      481 vtemevmqfl nrnqrlqpsa qaliyfrdss flssvpdawk sdfvseseea arriselksy
      541 lsrqkgitcr rypcewggva agrpyvggle efgqlvlqdv wnmiqklylq pgalleqpvs
      601 ipdddlvqat fqqlqkppsp arprllqdtv qrlmlphgrl slvtgqsgqg ktaflaslvs
      661 alqapdgakv aslvffhfsg arpdqglalt llrrlctylr gqlkepgalp styrslvwel
      721 qqrllpksae slhpgqtqvl iidgadrlvd qngqlisdwi pkklprcvhl vlsvssdagl
      781 getleqsqga hvlalgplea sararlvree lalygkrlee spfnnqmrll lvkresgrpl
      841 ylrlvtdhlr lftlyeqvse rlrtlpatvp lllqhilstl ekehgpdvlp qaltalevtr
      901 sgltvdqlhg vlsvwrtlpk gtksweeava agnsgdpypm gpfaclvqsl rsllgegple
      961 rpgarlclpd gplrtaakrc ygkrpgledt ahiliaaqlw ktcdadasgt frscppealg
     1021 dlpyhllqsg nrgllskflt nlhvvaahle lglvsrllea halyassvpk eeqklpeadv
     1081 avfrtflrqq asilsqyprl lpqqaanqpl dsplchqasl lsrrwhlqht lrwlnkprtm
     1141 knqqssslsl avsssptava fstngqraav gtangtvyll dlrtwqeeks vvsgcdgisa
     1201 clflsddtlf ltafdgllel wdlqhgcrvl qtkahqyqit gcclspdcrl latvclggcl
     1261 klwdtvrgql afqhtypksl ncvafhpegq viatgswags isffqvdglk vtkdlgapga
     1321 sirtlafnvp ggvvavgrld smvelwawre garlaafpah hgfvaaalfl hagcqlltag
     1381 edgkvqvwsg slgrprghlg slslspalsv alspdgdrva vgyradgiri ykissgsqga
     1441 qgqaldvavs alawlspkvl vsgaedgslq gwalkecslq slwllsrfqk pvlglatsqe
     1501 llasasedft vqlwprqllt rphkaedfpc gtelrghegp vsccsfstdg gslatggrdr
     1561 sllcwdvrtp ktpvlihsfp achrdwvtgc awtkdnllis cssdgsvglw dpesgqrlgq
     1621 flghqsavsa vaaveehvvs vsrdgtlkvw dhqgveltsi pahsgpishc aaamepraag
     1681 qpgsellvvt vgldgatrlw hpllvcqtht llghsgpvra aavsetsglm ltasedgsvr
     1741 lwqvpkeadd tciprssaav tavawapdgs mavsgnqage lilwqeakav ataqapghig
     1801 aliwssahtf fvlsadekis ewqvklrkgs apgnlslhln rilqedlgvl tsldwapdgh
     1861 flilakadlk llcmkpgdap seiwssyten pmilsthkey gifvlqpkdp gvlsflrqke
     1921 sgefeerlnf dinlenpsrt lisitqakpe sessflcass dgilwnlakc spegewttgn
     1981 mwqkkantpe tqtpgtdpst cresdasmds dasmdseptp hlktrqrrki hsgsvtalhv
     2041 lpellvtask drdvklwerp smqllglfrc egsvsclepw lganstlqla vgdvqgnvyf
     2101 lnwe
//
LOCUS       XP_047287691            1769 aa            linear   PRI 05-AUG-2025
DEFINITION  telomerase protein component 1 isoform X5 [Homo sapiens].
ACCESSION   XP_047287691
VERSION     XP_047287691.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431735.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1769
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1769
                     /product="telomerase protein component 1 isoform X5"
                     /calculated_mol_wt=198149
     Region          1..29
                     /region_name="TEP1_N"
                     /note="TEP1 N-terminal domain; pfam05386"
                     /db_xref="CDD:428450"
     Region          31..59
                     /region_name="TEP1_N"
                     /note="TEP1 N-terminal domain; pfam05386"
                     /db_xref="CDD:428450"
     Region          61..89
                     /region_name="TEP1_N"
                     /note="TEP1 N-terminal domain; pfam05386"
                     /db_xref="CDD:428450"
     Region          91..119
                     /region_name="TEP1_N"
                     /note="TEP1 N-terminal domain; pfam05386"
                     /db_xref="CDD:428450"
     Region          226..676
                     /region_name="TROVE"
                     /note="TROVE domain; pfam05731"
                     /db_xref="CDD:461724"
     Region          687..889
                     /region_name="DUF5920"
                     /note="Domain of unknown function (DUF5920); pfam19334"
                     /db_xref="CDD:466045"
     Region          900..1008
                     /region_name="DUF4062"
                     /note="Domain of unknown function (DUF4062); pfam13271"
                     /db_xref="CDD:463823"
     Region          1162..1337
                     /region_name="NACHT"
                     /note="NACHT domain; pfam05729"
                     /db_xref="CDD:428606"
     Region          <1680..>1749
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          1682..1717
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1721..1754
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..1769
                     /gene="TEP1"
                     /gene_synonym="p240; TLP1; TP1; TROVE1; VAULT2"
                     /coded_by="XM_047431735.1:156..5465"
                     /db_xref="GeneID:7011"
                     /db_xref="HGNC:HGNC:11726"
                     /db_xref="MIM:601686"
ORIGIN      
        1 meklhghvsa hpdilslenr clamlpdlqp leklhqhvst hsdilslknq clatlpdlkt
       61 mekphgyvsa hpdilslenq clatlsdlkt mekphghvsa hpdilslenr clatlsslks
      121 tvsasplfqs lqishmtqad lyrvnnsncl lseppswraq hfskgldlst cpialksisa
      181 tetaqeatlg rwfdseekkg aetqmpsysl slgeeeeved lavkltsgds eshpeptdhv
      241 lqekkmalls llcstlvsev nmnntsdptl aaifeicrel allepefilk aslyarqqln
      301 vrnvannila iaaflpacrp hlrryfcaiv qlpsdwiqva elyqslaegd knklvplpac
      361 lrtamtdkfa qfdeyqlaky nprkhrakrh prrpprspgm eppfshrcfp ryigflreeq
      421 rkfekagdtv sekknpprft lkklvqrlhi hkpaqhvqal lgyrypsnlq lfsrsrlpgp
      481 wdssragkrm klsrpetwer elslrgnkas vweeliengk lpfmamlrnl cnllrvgiss
      541 rhhelilqrl qhaksvihsr qfpfrflnah daidaleaql rnqalpfpsn itlmrriltr
      601 neknrprrrf lchlsrqqlr mamripvlye qlkreklrvh karqwkydge mlnryrqale
      661 tavnlsvkhs lpllpgrtvl vyltdanadr lcpksnpqgp plnyalllig mmitraeqvd
      721 vvlcggdtlk tavlkaeegi lktaiklqaq vqefdendgw slntfgkyll slagqrvpvd
      781 rvillgqsmd dgminvakql ywqrvnskcl fvgillrrvq ylstdlnpnd vtlsgctdai
      841 lkfiaehgas hllehvgqmd kifkippppg ktgvqslrpl eedtpsplap vsqqgwrsir
      901 lfisstfrdm hgerdlllrs vlpalqaraa phrislhgid lrwgvteeet rrnrqlevcl
      961 gevenaqlfv gilgsrygyi ppsynlpdhp hfhwaqqyps grsvtemevm qflnrnqrlq
     1021 psaqaliyfr dssflssvpd awksdfvses eeaarrisel ksylsrqkgi tcrrypcewg
     1081 gvaagrpyvg gleefgqlvl qdvwnmiqkl ylqpgalleq pvsipdddlv qatfqqlqkp
     1141 psparprllq dtvqrlmlph grlslvtgqs gqgktaflas lvsalqapdg akvaslvffh
     1201 fsgarpdqgl altllrrlct ylrgqlkepg alpstyrslv welqqrllpk saeslhpgqt
     1261 qvliidgadr lvdqngqlis dwipkklprc vhlvlsvssd aglgetleqs qgahvlalgp
     1321 leasararlv reelalygkr leespfnnqm rlllvkresg rplylrlvtd hlrlftlyeq
     1381 vserlrtlpa tvplllqhil stlekehgpd vlpqaltale vtrsgltvdq lhgvlsvwrt
     1441 lpkgtkswee avaagnsgdp ypmgpfaclv qslrsllgeg plerpgarlc lpdgplrtaa
     1501 krcygkrpgl edtahiliaa qlwktcdada sgtfrscppe algdlpyhll qsgnrgllsk
     1561 fltnlhvvaa hlelglvsrl leahalyass vpkeeqklpe advavfrtfl rqqasilsqy
     1621 prllpqqaan qpldsplchq asllsrrwhl qhtlrwlnkp rtmknqqsss lslavssspt
     1681 avafstngqr aavgtangtv ylldlrtwqe eksvvsgcdg isaclflsdd tlfltafdgl
     1741 lelwdlqhgc rcgtqsvgsw psstptpsp
//
LOCUS       XP_011535415             716 aa            linear   PRI 05-AUG-2025
DEFINITION  tumor necrosis factor alpha-induced protein 2 isoform X1 [Homo
            sapiens].
ACCESSION   XP_011535415
VERSION     XP_011535415.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537113.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..716
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..716
                     /product="tumor necrosis factor alpha-induced protein 2
                     isoform X1"
                     /calculated_mol_wt=79605
     Region          122..651
                     /region_name="Sec6"
                     /note="Exocyst complex component Sec6; pfam06046"
                     /db_xref="CDD:428738"
     CDS             1..716
                     /gene="TNFAIP2"
                     /gene_synonym="B94; EXOC3L3"
                     /coded_by="XM_011537113.3:327..2477"
                     /db_xref="GeneID:7127"
                     /db_xref="HGNC:HGNC:11895"
                     /db_xref="MIM:603300"
ORIGIN      
        1 mseassedlv ppleagaapy reeeeaakkk kekkkkskgl anvfcvftkg kkkkgqpssa
       61 epedaagsrq gldgppptve elkaalergq leaarpllal erelaaaaaa ggvseeelvr
      121 rqskvealye llrdqvlgvl rrpleapper lrqalavvae qeredrqaaa agpgtsglaa
      181 trprrwlqlw rrgvaeaaee rmgqrpaaga evpesvflhl grtmkedlea vverlkplfp
      241 aefgvvaaya esyhqhfaah laavaqfelc erdtymlllw vqnlypndii nspklvgelq
      301 gmglgsllpp rqirlleatf lsseaanvre lmdralelea rrwaedvppq rldghchsel
      361 aidiiqitsq aqakaesitl dlgsqikrvl lvelpaflrs yqrafnefle rgkqltnyra
      421 nvianinncl sfrmsmeqnw qvpqdtlsll lgplgelksh gfdtllqnlh edlkplfkrf
      481 thtrwaapve tleniiatvd trlpefselq gcfreelmea lhlhlvkeyi iqlskgrlvl
      541 ktaeqqqqla gyilanadti qhfctqhgsp atwlqpalpt laeiirlqdp saikievaty
      601 atcypdfskg hlsailaikg nlsnsevkri rsildvsmga qepsrplfsl ikpraavsgi
      661 qqwwngrqnw krkkekmssr lagafrvlwr avstasirrh iqvaprplqa gpamgp
//
LOCUS       XP_047287692             716 aa            linear   PRI 05-AUG-2025
DEFINITION  tumor necrosis factor alpha-induced protein 2 isoform X1 [Homo
            sapiens].
ACCESSION   XP_047287692
VERSION     XP_047287692.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431736.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..716
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..716
                     /product="tumor necrosis factor alpha-induced protein 2
                     isoform X1"
                     /calculated_mol_wt=79605
     Region          122..651
                     /region_name="Sec6"
                     /note="Exocyst complex component Sec6; pfam06046"
                     /db_xref="CDD:428738"
     CDS             1..716
                     /gene="TNFAIP2"
                     /gene_synonym="B94; EXOC3L3"
                     /coded_by="XM_047431736.1:227..2377"
                     /db_xref="GeneID:7127"
                     /db_xref="HGNC:HGNC:11895"
                     /db_xref="MIM:603300"
ORIGIN      
        1 mseassedlv ppleagaapy reeeeaakkk kekkkkskgl anvfcvftkg kkkkgqpssa
       61 epedaagsrq gldgppptve elkaalergq leaarpllal erelaaaaaa ggvseeelvr
      121 rqskvealye llrdqvlgvl rrpleapper lrqalavvae qeredrqaaa agpgtsglaa
      181 trprrwlqlw rrgvaeaaee rmgqrpaaga evpesvflhl grtmkedlea vverlkplfp
      241 aefgvvaaya esyhqhfaah laavaqfelc erdtymlllw vqnlypndii nspklvgelq
      301 gmglgsllpp rqirlleatf lsseaanvre lmdralelea rrwaedvppq rldghchsel
      361 aidiiqitsq aqakaesitl dlgsqikrvl lvelpaflrs yqrafnefle rgkqltnyra
      421 nvianinncl sfrmsmeqnw qvpqdtlsll lgplgelksh gfdtllqnlh edlkplfkrf
      481 thtrwaapve tleniiatvd trlpefselq gcfreelmea lhlhlvkeyi iqlskgrlvl
      541 ktaeqqqqla gyilanadti qhfctqhgsp atwlqpalpt laeiirlqdp saikievaty
      601 atcypdfskg hlsailaikg nlsnsevkri rsildvsmga qepsrplfsl ikpraavsgi
      661 qqwwngrqnw krkkekmssr lagafrvlwr avstasirrh iqvaprplqa gpamgp
//
LOCUS       XP_011535414             716 aa            linear   PRI 05-AUG-2025
DEFINITION  tumor necrosis factor alpha-induced protein 2 isoform X1 [Homo
            sapiens].
ACCESSION   XP_011535414
VERSION     XP_011535414.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537112.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..716
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..716
                     /product="tumor necrosis factor alpha-induced protein 2
                     isoform X1"
                     /calculated_mol_wt=79605
     Region          122..651
                     /region_name="Sec6"
                     /note="Exocyst complex component Sec6; pfam06046"
                     /db_xref="CDD:428738"
     CDS             1..716
                     /gene="TNFAIP2"
                     /gene_synonym="B94; EXOC3L3"
                     /coded_by="XM_011537112.3:772..2922"
                     /db_xref="GeneID:7127"
                     /db_xref="HGNC:HGNC:11895"
                     /db_xref="MIM:603300"
ORIGIN      
        1 mseassedlv ppleagaapy reeeeaakkk kekkkkskgl anvfcvftkg kkkkgqpssa
       61 epedaagsrq gldgppptve elkaalergq leaarpllal erelaaaaaa ggvseeelvr
      121 rqskvealye llrdqvlgvl rrpleapper lrqalavvae qeredrqaaa agpgtsglaa
      181 trprrwlqlw rrgvaeaaee rmgqrpaaga evpesvflhl grtmkedlea vverlkplfp
      241 aefgvvaaya esyhqhfaah laavaqfelc erdtymlllw vqnlypndii nspklvgelq
      301 gmglgsllpp rqirlleatf lsseaanvre lmdralelea rrwaedvppq rldghchsel
      361 aidiiqitsq aqakaesitl dlgsqikrvl lvelpaflrs yqrafnefle rgkqltnyra
      421 nvianinncl sfrmsmeqnw qvpqdtlsll lgplgelksh gfdtllqnlh edlkplfkrf
      481 thtrwaapve tleniiatvd trlpefselq gcfreelmea lhlhlvkeyi iqlskgrlvl
      541 ktaeqqqqla gyilanadti qhfctqhgsp atwlqpalpt laeiirlqdp saikievaty
      601 atcypdfskg hlsailaikg nlsnsevkri rsildvsmga qepsrplfsl ikpraavsgi
      661 qqwwngrqnw krkkekmssr lagafrvlwr avstasirrh iqvaprplqa gpamgp
//
LOCUS       XP_047287693             716 aa            linear   PRI 05-AUG-2025
DEFINITION  tumor necrosis factor alpha-induced protein 2 isoform X1 [Homo
            sapiens].
ACCESSION   XP_047287693
VERSION     XP_047287693.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431737.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..716
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..716
                     /product="tumor necrosis factor alpha-induced protein 2
                     isoform X1"
                     /calculated_mol_wt=79605
     Region          122..651
                     /region_name="Sec6"
                     /note="Exocyst complex component Sec6; pfam06046"
                     /db_xref="CDD:428738"
     CDS             1..716
                     /gene="TNFAIP2"
                     /gene_synonym="B94; EXOC3L3"
                     /coded_by="XM_047431737.1:459..2609"
                     /db_xref="GeneID:7127"
                     /db_xref="HGNC:HGNC:11895"
                     /db_xref="MIM:603300"
ORIGIN      
        1 mseassedlv ppleagaapy reeeeaakkk kekkkkskgl anvfcvftkg kkkkgqpssa
       61 epedaagsrq gldgppptve elkaalergq leaarpllal erelaaaaaa ggvseeelvr
      121 rqskvealye llrdqvlgvl rrpleapper lrqalavvae qeredrqaaa agpgtsglaa
      181 trprrwlqlw rrgvaeaaee rmgqrpaaga evpesvflhl grtmkedlea vverlkplfp
      241 aefgvvaaya esyhqhfaah laavaqfelc erdtymlllw vqnlypndii nspklvgelq
      301 gmglgsllpp rqirlleatf lsseaanvre lmdralelea rrwaedvppq rldghchsel
      361 aidiiqitsq aqakaesitl dlgsqikrvl lvelpaflrs yqrafnefle rgkqltnyra
      421 nvianinncl sfrmsmeqnw qvpqdtlsll lgplgelksh gfdtllqnlh edlkplfkrf
      481 thtrwaapve tleniiatvd trlpefselq gcfreelmea lhlhlvkeyi iqlskgrlvl
      541 ktaeqqqqla gyilanadti qhfctqhgsp atwlqpalpt laeiirlqdp saikievaty
      601 atcypdfskg hlsailaikg nlsnsevkri rsildvsmga qepsrplfsl ikpraavsgi
      661 qqwwngrqnw krkkekmssr lagafrvlwr avstasirrh iqvaprplqa gpamgp
//
LOCUS       XP_016877106             568 aa            linear   PRI 05-AUG-2025
DEFINITION  TNF receptor-associated factor 3 isoform X1 [Homo sapiens].
ACCESSION   XP_016877106
VERSION     XP_016877106.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021617.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..568
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..568
                     /product="TNF receptor-associated factor 3 isoform X1"
                     /calculated_mol_wt=64359
     Region          51..92
                     /region_name="RING-HC_TRAF3"
                     /note="RING finger, HC subclass, found in tumor necrosis
                     factor (TNF) receptor-associated factor 3 (TRAF3) and
                     similar proteins; cd16640"
                     /db_xref="CDD:438302"
     Region          136..192
                     /region_name="zf-TRAF"
                     /note="TRAF-type zinc finger; pfam02176"
                     /db_xref="CDD:280357"
     Region          197..247
                     /region_name="zf-TRAF"
                     /note="TRAF-type zinc finger; pfam02176"
                     /db_xref="CDD:280357"
     Region          <258..>368
                     /region_name="Mplasa_alph_rch"
                     /note="helix-rich Mycoplasma protein; TIGR04523"
                     /db_xref="CDD:275316"
     Region          378..563
                     /region_name="MATH_TRAF3"
                     /note="Tumor Necrosis Factor Receptor (TNFR)-Associated
                     Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF
                     molecules serve as adapter proteins that link TNFRs and
                     downstream kinase cascades resulting in the activation of
                     transcription factors and the...; cd03777"
                     /db_xref="CDD:239746"
     Site            order(399,402,410,412,419,421,449..450,481,484,501)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:239746"
     Site            order(457,459,463,465,474,512,515,520,530..533)
                     /site_type="active"
                     /note="TNFR binding site [active]"
                     /db_xref="CDD:239746"
     CDS             1..568
                     /gene="TRAF3"
                     /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; IMD132A;
                     IMD132B; LAP1; RNF118"
                     /coded_by="XM_017021617.2:844..2550"
                     /db_xref="GeneID:7187"
                     /db_xref="HGNC:HGNC:12033"
                     /db_xref="MIM:601896"
ORIGIN      
        1 messkkmdsp galqtnpplk lhtdrsagtp vfvpeqggyk ekfvktvedk ykcekchlvl
       61 cspkqtecgh rfcescmaal lsssspkcta cqesivkdkv fkdncckrei lalqiycrne
      121 srgcaeqlml ghllvhlknd chfeelpcvr pdckekvlrk dlrdhvekac kyreatcshc
      181 ksqvpmialq khedtdcpcv vvscphkcsv qtllrselsa hlsecvnaps tcsfkrygcv
      241 fqgtnqqika heassavqhv nllkewsnsl ekkvsllqne sveknksiqs lhnqicsfei
      301 eierqkemlr nneskilhlq rvidsqaekl keldkeirpf rqnweeadsm kssveslqnr
      361 vtelesvdks agqvarntgl lesqlsrhdq mlsvhdirla dmdlrfqvle tasyngvliw
      421 kirdykrrkq eavmgktlsl ysqpfytgyf gykmcarvyl ngdgmgkgth lslffvimrg
      481 eydallpwpf kqkvtlmlmd qgssrrhlgd afkpdpnsss fkkptgemni asgcpvfvaq
      541 tvlengtyik ddtifikviv dtsdlpdp
//
LOCUS       XP_047287694             568 aa            linear   PRI 05-AUG-2025
DEFINITION  TNF receptor-associated factor 3 isoform X1 [Homo sapiens].
ACCESSION   XP_047287694
VERSION     XP_047287694.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431738.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..568
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..568
                     /product="TNF receptor-associated factor 3 isoform X1"
                     /calculated_mol_wt=64359
     Region          51..92
                     /region_name="RING-HC_TRAF3"
                     /note="RING finger, HC subclass, found in tumor necrosis
                     factor (TNF) receptor-associated factor 3 (TRAF3) and
                     similar proteins; cd16640"
                     /db_xref="CDD:438302"
     Region          136..192
                     /region_name="zf-TRAF"
                     /note="TRAF-type zinc finger; pfam02176"
                     /db_xref="CDD:280357"
     Region          197..247
                     /region_name="zf-TRAF"
                     /note="TRAF-type zinc finger; pfam02176"
                     /db_xref="CDD:280357"
     Region          <258..>368
                     /region_name="Mplasa_alph_rch"
                     /note="helix-rich Mycoplasma protein; TIGR04523"
                     /db_xref="CDD:275316"
     Region          378..563
                     /region_name="MATH_TRAF3"
                     /note="Tumor Necrosis Factor Receptor (TNFR)-Associated
                     Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF
                     molecules serve as adapter proteins that link TNFRs and
                     downstream kinase cascades resulting in the activation of
                     transcription factors and the...; cd03777"
                     /db_xref="CDD:239746"
     Site            order(399,402,410,412,419,421,449..450,481,484,501)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:239746"
     Site            order(457,459,463,465,474,512,515,520,530..533)
                     /site_type="active"
                     /note="TNFR binding site [active]"
                     /db_xref="CDD:239746"
     CDS             1..568
                     /gene="TRAF3"
                     /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; IMD132A;
                     IMD132B; LAP1; RNF118"
                     /coded_by="XM_047431738.1:555..2261"
                     /db_xref="GeneID:7187"
                     /db_xref="HGNC:HGNC:12033"
                     /db_xref="MIM:601896"
ORIGIN      
        1 messkkmdsp galqtnpplk lhtdrsagtp vfvpeqggyk ekfvktvedk ykcekchlvl
       61 cspkqtecgh rfcescmaal lsssspkcta cqesivkdkv fkdncckrei lalqiycrne
      121 srgcaeqlml ghllvhlknd chfeelpcvr pdckekvlrk dlrdhvekac kyreatcshc
      181 ksqvpmialq khedtdcpcv vvscphkcsv qtllrselsa hlsecvnaps tcsfkrygcv
      241 fqgtnqqika heassavqhv nllkewsnsl ekkvsllqne sveknksiqs lhnqicsfei
      301 eierqkemlr nneskilhlq rvidsqaekl keldkeirpf rqnweeadsm kssveslqnr
      361 vtelesvdks agqvarntgl lesqlsrhdq mlsvhdirla dmdlrfqvle tasyngvliw
      421 kirdykrrkq eavmgktlsl ysqpfytgyf gykmcarvyl ngdgmgkgth lslffvimrg
      481 eydallpwpf kqkvtlmlmd qgssrrhlgd afkpdpnsss fkkptgemni asgcpvfvaq
      541 tvlengtyik ddtifikviv dtsdlpdp
//
LOCUS       XP_016877108             543 aa            linear   PRI 05-AUG-2025
DEFINITION  TNF receptor-associated factor 3 isoform X2 [Homo sapiens].
ACCESSION   XP_016877108
VERSION     XP_016877108.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021619.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..543
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..543
                     /product="TNF receptor-associated factor 3 isoform X2"
                     /calculated_mol_wt=61629
     Region          51..92
                     /region_name="RING-HC_TRAF3"
                     /note="RING finger, HC subclass, found in tumor necrosis
                     factor (TNF) receptor-associated factor 3 (TRAF3) and
                     similar proteins; cd16640"
                     /db_xref="CDD:438302"
     Region          136..192
                     /region_name="zf-TRAF"
                     /note="TRAF-type zinc finger; pfam02176"
                     /db_xref="CDD:280357"
     Region          <214..>343
                     /region_name="Mplasa_alph_rch"
                     /note="helix-rich Mycoplasma protein; TIGR04523"
                     /db_xref="CDD:275316"
     Region          353..538
                     /region_name="MATH_TRAF3"
                     /note="Tumor Necrosis Factor Receptor (TNFR)-Associated
                     Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF
                     molecules serve as adapter proteins that link TNFRs and
                     downstream kinase cascades resulting in the activation of
                     transcription factors and the...; cd03777"
                     /db_xref="CDD:239746"
     Site            order(374,377,385,387,394,396,424..425,456,459,476)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:239746"
     Site            order(432,434,438,440,449,487,490,495,505..508)
                     /site_type="active"
                     /note="TNFR binding site [active]"
                     /db_xref="CDD:239746"
     CDS             1..543
                     /gene="TRAF3"
                     /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; IMD132A;
                     IMD132B; LAP1; RNF118"
                     /coded_by="XM_017021619.2:8107..9738"
                     /db_xref="GeneID:7187"
                     /db_xref="HGNC:HGNC:12033"
                     /db_xref="MIM:601896"
ORIGIN      
        1 messkkmdsp galqtnpplk lhtdrsagtp vfvpeqggyk ekfvktvedk ykcekchlvl
       61 cspkqtecgh rfcescmaal lsssspkcta cqesivkdkv fkdncckrei lalqiycrne
      121 srgcaeqlml ghllvhlknd chfeelpcvr pdckekvlrk dlrdhvekac kyreatcshc
      181 ksqvpmialq khedtdcpcv vvscphkcsv qtllrsegtn qqikaheass avqhvnllke
      241 wsnslekkvs llqnesvekn ksiqslhnqi csfeieierq kemlrnnesk ilhlqrvids
      301 qaeklkeldk eirpfrqnwe eadsmkssve slqnrvtele svdksagqva rntgllesql
      361 srhdqmlsvh dirladmdlr fqvletasyn gvliwkirdy krrkqeavmg ktlslysqpf
      421 ytgyfgykmc arvylngdgm gkgthlslff vimrgeydal lpwpfkqkvt lmlmdqgssr
      481 rhlgdafkpd pnsssfkkpt gemniasgcp vfvaqtvlen gtyikddtif ikvivdtsdl
      541 pdp
//
LOCUS       XP_047287695             543 aa            linear   PRI 05-AUG-2025
DEFINITION  TNF receptor-associated factor 3 isoform X2 [Homo sapiens].
ACCESSION   XP_047287695
VERSION     XP_047287695.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431739.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..543
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..543
                     /product="TNF receptor-associated factor 3 isoform X2"
                     /calculated_mol_wt=61629
     Region          51..92
                     /region_name="RING-HC_TRAF3"
                     /note="RING finger, HC subclass, found in tumor necrosis
                     factor (TNF) receptor-associated factor 3 (TRAF3) and
                     similar proteins; cd16640"
                     /db_xref="CDD:438302"
     Region          136..192
                     /region_name="zf-TRAF"
                     /note="TRAF-type zinc finger; pfam02176"
                     /db_xref="CDD:280357"
     Region          <214..>343
                     /region_name="Mplasa_alph_rch"
                     /note="helix-rich Mycoplasma protein; TIGR04523"
                     /db_xref="CDD:275316"
     Region          353..538
                     /region_name="MATH_TRAF3"
                     /note="Tumor Necrosis Factor Receptor (TNFR)-Associated
                     Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF
                     molecules serve as adapter proteins that link TNFRs and
                     downstream kinase cascades resulting in the activation of
                     transcription factors and the...; cd03777"
                     /db_xref="CDD:239746"
     Site            order(374,377,385,387,394,396,424..425,456,459,476)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:239746"
     Site            order(432,434,438,440,449,487,490,495,505..508)
                     /site_type="active"
                     /note="TNFR binding site [active]"
                     /db_xref="CDD:239746"
     CDS             1..543
                     /gene="TRAF3"
                     /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; IMD132A;
                     IMD132B; LAP1; RNF118"
                     /coded_by="XM_047431739.1:245..1876"
                     /db_xref="GeneID:7187"
                     /db_xref="HGNC:HGNC:12033"
                     /db_xref="MIM:601896"
ORIGIN      
        1 messkkmdsp galqtnpplk lhtdrsagtp vfvpeqggyk ekfvktvedk ykcekchlvl
       61 cspkqtecgh rfcescmaal lsssspkcta cqesivkdkv fkdncckrei lalqiycrne
      121 srgcaeqlml ghllvhlknd chfeelpcvr pdckekvlrk dlrdhvekac kyreatcshc
      181 ksqvpmialq khedtdcpcv vvscphkcsv qtllrsegtn qqikaheass avqhvnllke
      241 wsnslekkvs llqnesvekn ksiqslhnqi csfeieierq kemlrnnesk ilhlqrvids
      301 qaeklkeldk eirpfrqnwe eadsmkssve slqnrvtele svdksagqva rntgllesql
      361 srhdqmlsvh dirladmdlr fqvletasyn gvliwkirdy krrkqeavmg ktlslysqpf
      421 ytgyfgykmc arvylngdgm gkgthlslff vimrgeydal lpwpfkqkvt lmlmdqgssr
      481 rhlgdafkpd pnsssfkkpt gemniasgcp vfvaqtvlen gtyikddtif ikvivdtsdl
      541 pdp
//
LOCUS       XP_047287696             516 aa            linear   PRI 05-AUG-2025
DEFINITION  TNF receptor-associated factor 3 isoform X3 [Homo sapiens].
ACCESSION   XP_047287696
VERSION     XP_047287696.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431740.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..516
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..516
                     /product="TNF receptor-associated factor 3 isoform X3"
                     /calculated_mol_wt=58633
     Region          51..92
                     /region_name="RING-HC_TRAF3"
                     /note="RING finger, HC subclass, found in tumor necrosis
                     factor (TNF) receptor-associated factor 3 (TRAF3) and
                     similar proteins; cd16640"
                     /db_xref="CDD:438302"
     Region          136..190
                     /region_name="zf-TRAF"
                     /note="TRAF-type zinc finger; pfam02176"
                     /db_xref="CDD:280357"
     Region          <181..>338
                     /region_name="Cast"
                     /note="RIM-binding protein of the cytomatrix active zone;
                     pfam10174"
                     /db_xref="CDD:431111"
     Region          326..511
                     /region_name="MATH_TRAF3"
                     /note="Tumor Necrosis Factor Receptor (TNFR)-Associated
                     Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF
                     molecules serve as adapter proteins that link TNFRs and
                     downstream kinase cascades resulting in the activation of
                     transcription factors and the...; cd03777"
                     /db_xref="CDD:239746"
     Site            order(347,350,358,360,367,369,397..398,429,432,449)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:239746"
     Site            order(405,407,411,413,422,460,463,468,478..481)
                     /site_type="active"
                     /note="TNFR binding site [active]"
                     /db_xref="CDD:239746"
     CDS             1..516
                     /gene="TRAF3"
                     /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; IMD132A;
                     IMD132B; LAP1; RNF118"
                     /coded_by="XM_047431740.1:245..1795"
                     /db_xref="GeneID:7187"
                     /db_xref="HGNC:HGNC:12033"
                     /db_xref="MIM:601896"
ORIGIN      
        1 messkkmdsp galqtnpplk lhtdrsagtp vfvpeqggyk ekfvktvedk ykcekchlvl
       61 cspkqtecgh rfcescmaal lsssspkcta cqesivkdkv fkdncckrei lalqiycrne
      121 srgcaeqlml ghllvhlknd chfeelpcvr pdckekvlrk dlrdhvekac kyreatcshc
      181 ksqvpmialq gtnqqikahe assavqhvnl lkewsnslek kvsllqnesv eknksiqslh
      241 nqicsfeiei erqkemlrnn eskilhlqrv idsqaeklke ldkeirpfrq nweeadsmks
      301 sveslqnrvt elesvdksag qvarntglle sqlsrhdqml svhdirladm dlrfqvleta
      361 syngvliwki rdykrrkqea vmgktlslys qpfytgyfgy kmcarvylng dgmgkgthls
      421 lffvimrgey dallpwpfkq kvtlmlmdqg ssrrhlgdaf kpdpnsssfk kptgemnias
      481 gcpvfvaqtv lengtyikdd tifikvivdt sdlpdp
//
LOCUS       XP_047287697             512 aa            linear   PRI 05-AUG-2025
DEFINITION  TNF receptor-associated factor 3 isoform X4 [Homo sapiens].
ACCESSION   XP_047287697
VERSION     XP_047287697.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431741.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..512
                     /product="TNF receptor-associated factor 3 isoform X4"
                     /calculated_mol_wt=58171
     Region          51..92
                     /region_name="RING-HC_TRAF3"
                     /note="RING finger, HC subclass, found in tumor necrosis
                     factor (TNF) receptor-associated factor 3 (TRAF3) and
                     similar proteins; cd16640"
                     /db_xref="CDD:438302"
     Region          136..192
                     /region_name="zf-TRAF"
                     /note="TRAF-type zinc finger; pfam02176"
                     /db_xref="CDD:280357"
     Region          <214..>312
                     /region_name="Mplasa_alph_rch"
                     /note="helix-rich Mycoplasma protein; TIGR04523"
                     /db_xref="CDD:275316"
     Region          322..507
                     /region_name="MATH_TRAF3"
                     /note="Tumor Necrosis Factor Receptor (TNFR)-Associated
                     Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF
                     molecules serve as adapter proteins that link TNFRs and
                     downstream kinase cascades resulting in the activation of
                     transcription factors and the...; cd03777"
                     /db_xref="CDD:239746"
     Site            order(343,346,354,356,363,365,393..394,425,428,445)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:239746"
     Site            order(401,403,407,409,418,456,459,464,474..477)
                     /site_type="active"
                     /note="TNFR binding site [active]"
                     /db_xref="CDD:239746"
     CDS             1..512
                     /gene="TRAF3"
                     /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; IMD132A;
                     IMD132B; LAP1; RNF118"
                     /coded_by="XM_047431741.1:8107..9645"
                     /db_xref="GeneID:7187"
                     /db_xref="HGNC:HGNC:12033"
                     /db_xref="MIM:601896"
ORIGIN      
        1 messkkmdsp galqtnpplk lhtdrsagtp vfvpeqggyk ekfvktvedk ykcekchlvl
       61 cspkqtecgh rfcescmaal lsssspkcta cqesivkdkv fkdncckrei lalqiycrne
      121 srgcaeqlml ghllvhlknd chfeelpcvr pdckekvlrk dlrdhvekac kyreatcshc
      181 ksqvpmialq khedtdcpcv vvscphkcsv qtllrsevsl lqnesveknk siqslhnqic
      241 sfeieierqk emlrnneski lhlqrvidsq aeklkeldke irpfrqnwee adsmkssves
      301 lqnrvteles vdksagqvar ntgllesqls rhdqmlsvhd irladmdlrf qvletasyng
      361 vliwkirdyk rrkqeavmgk tlslysqpfy tgyfgykmca rvylngdgmg kgthlslffv
      421 imrgeydall pwpfkqkvtl mlmdqgssrr hlgdafkpdp nsssfkkptg emniasgcpv
      481 fvaqtvleng tyikddtifi kvivdtsdlp dp
//
LOCUS       XP_047287698             512 aa            linear   PRI 05-AUG-2025
DEFINITION  TNF receptor-associated factor 3 isoform X4 [Homo sapiens].
ACCESSION   XP_047287698
VERSION     XP_047287698.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431742.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..512
                     /product="TNF receptor-associated factor 3 isoform X4"
                     /calculated_mol_wt=58171
     Region          51..92
                     /region_name="RING-HC_TRAF3"
                     /note="RING finger, HC subclass, found in tumor necrosis
                     factor (TNF) receptor-associated factor 3 (TRAF3) and
                     similar proteins; cd16640"
                     /db_xref="CDD:438302"
     Region          136..192
                     /region_name="zf-TRAF"
                     /note="TRAF-type zinc finger; pfam02176"
                     /db_xref="CDD:280357"
     Region          <214..>312
                     /region_name="Mplasa_alph_rch"
                     /note="helix-rich Mycoplasma protein; TIGR04523"
                     /db_xref="CDD:275316"
     Region          322..507
                     /region_name="MATH_TRAF3"
                     /note="Tumor Necrosis Factor Receptor (TNFR)-Associated
                     Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF
                     molecules serve as adapter proteins that link TNFRs and
                     downstream kinase cascades resulting in the activation of
                     transcription factors and the...; cd03777"
                     /db_xref="CDD:239746"
     Site            order(343,346,354,356,363,365,393..394,425,428,445)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:239746"
     Site            order(401,403,407,409,418,456,459,464,474..477)
                     /site_type="active"
                     /note="TNFR binding site [active]"
                     /db_xref="CDD:239746"
     CDS             1..512
                     /gene="TRAF3"
                     /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; IMD132A;
                     IMD132B; LAP1; RNF118"
                     /coded_by="XM_047431742.1:245..1783"
                     /db_xref="GeneID:7187"
                     /db_xref="HGNC:HGNC:12033"
                     /db_xref="MIM:601896"
ORIGIN      
        1 messkkmdsp galqtnpplk lhtdrsagtp vfvpeqggyk ekfvktvedk ykcekchlvl
       61 cspkqtecgh rfcescmaal lsssspkcta cqesivkdkv fkdncckrei lalqiycrne
      121 srgcaeqlml ghllvhlknd chfeelpcvr pdckekvlrk dlrdhvekac kyreatcshc
      181 ksqvpmialq khedtdcpcv vvscphkcsv qtllrsevsl lqnesveknk siqslhnqic
      241 sfeieierqk emlrnneski lhlqrvidsq aeklkeldke irpfrqnwee adsmkssves
      301 lqnrvteles vdksagqvar ntgllesqls rhdqmlsvhd irladmdlrf qvletasyng
      361 vliwkirdyk rrkqeavmgk tlslysqpfy tgyfgykmca rvylngdgmg kgthlslffv
      421 imrgeydall pwpfkqkvtl mlmdqgssrr hlgdafkpdp nsssfkkptg emniasgcpv
      481 fvaqtvleng tyikddtifi kvivdtsdlp dp
//
LOCUS       XP_016877109             292 aa            linear   PRI 05-AUG-2025
DEFINITION  TNF receptor-associated factor 3 isoform X6 [Homo sapiens].
ACCESSION   XP_016877109
VERSION     XP_016877109.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021620.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..292
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..292
                     /product="TNF receptor-associated factor 3 isoform X6"
                     /calculated_mol_wt=32617
     Region          44..>246
                     /region_name="rad18"
                     /note="DNA repair protein rad18; TIGR00599"
                     /db_xref="CDD:273165"
     Region          51..92
                     /region_name="RING-HC_TRAF3"
                     /note="RING finger, HC subclass, found in tumor necrosis
                     factor (TNF) receptor-associated factor 3 (TRAF3) and
                     similar proteins; cd16640"
                     /db_xref="CDD:438302"
     Region          136..192
                     /region_name="zf-TRAF"
                     /note="TRAF-type zinc finger; pfam02176"
                     /db_xref="CDD:280357"
     CDS             1..292
                     /gene="TRAF3"
                     /gene_synonym="CAP-1; CAP1; CD40bp; CRAF1; IIAE5; IMD132A;
                     IMD132B; LAP1; RNF118"
                     /coded_by="XM_017021620.3:384..1262"
                     /db_xref="GeneID:7187"
                     /db_xref="HGNC:HGNC:12033"
                     /db_xref="MIM:601896"
ORIGIN      
        1 messkkmdsp galqtnpplk lhtdrsagtp vfvpeqggyk ekfvktvedk ykcekchlvl
       61 cspkqtecgh rfcescmaal lsssspkcta cqesivkdkv fkdncckrei lalqiycrne
      121 srgcaeqlml ghllvhlknd chfeelpcvr pdckekvlrk dlrdhvekac kyreatcshc
      181 ksqvpmialq khedtdcpcv vvscphkcsv qtllrselsa hlsecvnaps tcsfkrygcv
      241 fqgtnqqika heassavqhv nllkewsnsl ekkgyenkes ensvpsltdg ne
//
LOCUS       XP_011535421             671 aa            linear   PRI 05-AUG-2025
DEFINITION  thyrotropin receptor isoform X1 [Homo sapiens].
ACCESSION   XP_011535421
VERSION     XP_011535421.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537119.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..671
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..671
                     /product="thyrotropin receptor isoform X1"
                     /calculated_mol_wt=76334
     Region          54..84
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          87..108
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          109..136
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          156..178
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          179..212
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          322..596
                     /region_name="7tmA_TSH-R"
                     /note="thyroid-stimulating hormone receptor (or
                     thyrotropin receptor), member of the class A family of
                     seven-transmembrane G protein-coupled receptors; cd15964"
                     /db_xref="CDD:320630"
     Region          323..349
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:320630"
     Region          356..381
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320630"
     Site            order(377,380..381,401..406,408..409,412,457,459..463,485,
                     488..490,492..494,496..497,544,547..548,550..551,554,
                     563..564,566..568,571,574..575)
                     /site_type="other"
                     /note="putative peptide ligand binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:320630"
     Region          401..431
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320630"
     Region          443..465
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320630"
     Region          485..514
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320630"
     Region          524..554
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320630"
     Region          564..589
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320630"
     CDS             1..671
                     /gene="TSHR"
                     /gene_synonym="CHNG1; hTSHR-I; LGR3"
                     /coded_by="XM_011537119.3:70..2085"
                     /db_xref="GeneID:7253"
                     /db_xref="HGNC:HGNC:12373"
                     /db_xref="MIM:603372"
ORIGIN      
        1 mhysdcvpcn lyreirntrn ltyidpdalk elpllkflgi fntglkmfpd ltkvystdif
       61 fileitdnpy mtsipvnafq glcnetltlk lynngftsvq gyafngtkld avylnknkyl
      121 tvidkdafgg vysgpslldv sqtsvtalps kglehlkeli arntwtlkkl plslsflhlt
      181 radlsypshc cafknqkkir gileslmcne ssmqslrqrk svnalnsplh qeyeenlgds
      241 ivgykekskf qdthnnahyy vffeeqedei igfgqelknp qeetlqafds hydyticgds
      301 edmvctpksd efnpcedimg ykflrivvwf vsllallgnv fvllilltsh yklnvprflm
      361 cnlafadfcm gmyllliasv dlythseyyn haidwqtgpg cntagfftvf aselsvytlt
      421 vitlerwyai tfamrldrki rlrhacaimv ggwvccflla llplvgissy akvsiclpmd
      481 tetplalayi vfvltlniva fvivcccyvk iyitvrnpqy npgdkdtkia krmavliftd
      541 ficmapisfy alsailnkpl itvsnskill vlfyplnsca npflyaiftk afqrdvfill
      601 skfgickrqa qayrgqrvpp knstdiqvqk vthemrqglh nmedvyelie nshltpkkqg
      661 qiseeymqtv l
//
LOCUS       XP_011535422             794 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 175 isoform X1 [Homo
            sapiens].
ACCESSION   XP_011535422
VERSION     XP_011535422.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537120.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..794
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..794
                     /product="coiled-coil domain-containing protein 175
                     isoform X1"
                     /calculated_mol_wt=93623
     Region          66..738
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..794
                     /gene="CCDC175"
                     /gene_synonym="C14orf38; c14_5395"
                     /coded_by="XM_011537120.4:38..2422"
                     /db_xref="GeneID:729665"
                     /db_xref="HGNC:HGNC:19847"
ORIGIN      
        1 malspwtpgl gageklvqaa avstgpslel ctlpstlgss vavealeqlf vveqslqsdy
       61 fkcneeakif lkdiavavkk leemrkatid lleiesmeln klyylletlp nsikreleec
      121 vrdarrlnlf eintikmrit rteneiellk kkitdltkyn ealgekqeel arkharfvls
      181 lnqtmekkat ttvyinetyt kinlkredia lqkkciqeae elmekeraey lirkqeltaq
      241 inefentrev krmetyqkkk eldklqtkms kiketvtvsa avlsdhnlei arlhesiryw
      301 eqevselkkd laileaklcf ftdnkekldd isndeknefl nkikqlvetl haarmeykdl
      361 rekmktlarq ykivlseeek aflqkqkihd enqkqltfis qkeyflsqkr vdiknmeegl
      421 itlqelqqat ktvyqqqiki lsanleresq rcvitqwkma clrkkharwt akikaeiqai
      481 tekiqnaevr riellnetsf rqqeisgfva qieklttelk eeekafvnke kmlmkelsky
      541 eeifvketqi nkekeeelve ylpqlqvaeq eykekrrkle elsniitaqr qeedllnnhi
      601 flftrdfsry isnmqedvkq elqqlrdqes kknkdhfetl knlengfyin dqkadlllle
      661 nkklkeyily lknniekyre gqealmhtss dlsrqliaqe aqykdlwaef qttvkilvdn
      721 geetlqdinn ltdklrerde kmqhvstwlr gsleglrllv eqespmdllk kkkhirtrvh
      781 fpvvkctekn tltk
//
LOCUS       XP_011535424             720 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 175 isoform X2 [Homo
            sapiens].
ACCESSION   XP_011535424
VERSION     XP_011535424.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537122.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..720
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..720
                     /product="coiled-coil domain-containing protein 175
                     isoform X2"
                     /calculated_mol_wt=84536
     Region          112..>391
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <314..>560
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          471..>709
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..720
                     /gene="CCDC175"
                     /gene_synonym="C14orf38; c14_5395"
                     /coded_by="XM_011537122.4:38..2200"
                     /db_xref="GeneID:729665"
                     /db_xref="HGNC:HGNC:19847"
ORIGIN      
        1 malspwtpgl gageklvqaa avstgpslel ctlpstlgss vavealeqlf vveqslqsdy
       61 fkcneeakif lkdiavavkk leemrkatid lleiesmeln klyylletlp nsikreleec
      121 vrdarrlnlf eintikmrit rteneiellk kkitdltkyn ealgekqeel arkharfvls
      181 lnqtmekkat ttvyinetyt kinlkredia lqkkciqeae elmekeraey lirkqeltaq
      241 inefentrev krmetyqkkk eldklqtkms kiketvtvsa avlsdhnlei arlhesiryw
      301 eqevselkkd laileaklcf ftdnkekldd isndeknefl nkikqlvetl haarmeykdl
      361 rekmktlarq ykivlseeek aflqkqkihd enqkqltfis qkeyflsqkr vdiknmeegl
      421 itlqelqqat ktvyqqqiki lsanleresq rcvitqwkma clrkkharwt akikaeiqai
      481 tekiqnaevr riellnetsf rqqeisgfva qieklttelk eeekafvnke kmlmkelsky
      541 eedvkqelqq lrdqeskknk dhfetlknle ngfyindqka dllllenkkl keyilylknn
      601 iekyregqea lmhtssdlsr qliaqeaqyk dlwaefqttv kilvdngeet lqdinnltdk
      661 lrerdekmqh vstwlrgsle glrllveqes pmdllkkkkh irtrvhfpvv kctekntltk
//
LOCUS       XP_011535426             669 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 175 isoform X3 [Homo
            sapiens].
ACCESSION   XP_011535426
VERSION     XP_011535426.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537124.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..669
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..669
                     /product="coiled-coil domain-containing protein 175
                     isoform X3"
                     /calculated_mol_wt=78394
     Region          112..>391
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <314..618
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     CDS             1..669
                     /gene="CCDC175"
                     /gene_synonym="C14orf38; c14_5395"
                     /coded_by="XM_011537124.4:38..2047"
                     /db_xref="GeneID:729665"
                     /db_xref="HGNC:HGNC:19847"
ORIGIN      
        1 malspwtpgl gageklvqaa avstgpslel ctlpstlgss vavealeqlf vveqslqsdy
       61 fkcneeakif lkdiavavkk leemrkatid lleiesmeln klyylletlp nsikreleec
      121 vrdarrlnlf eintikmrit rteneiellk kkitdltkyn ealgekqeel arkharfvls
      181 lnqtmekkat ttvyinetyt kinlkredia lqkkciqeae elmekeraey lirkqeltaq
      241 inefentrev krmetyqkkk eldklqtkms kiketvtvsa avlsdhnlei arlhesiryw
      301 eqevselkkd laileaklcf ftdnkekldd isndeknefl nkikqlvetl haarmeykdl
      361 rekmktlarq ykivlseeek aflqkqkihd enqkqltfis qkeyflsqkr vdiknmeegl
      421 itlqelqqat ktvyqqqiki lsanleresq rcvitqwkma clrkkharwt akikaeiqai
      481 tekiqnaevr riellnetsf rqqeisgfva qieklttelk eeekafvnke kmlmkelsky
      541 eyilylknni ekyregqeal mhtssdlsrq liaqeaqykd lwaefqttvk ilvdngeetl
      601 qdinnltdkl rerdekmqhv stwlrgsleg lrllveqesp mdllkkkkhi rtrvhfpvvk
      661 ctekntltk
//
LOCUS       XP_011535427             646 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 175 isoform X4 [Homo
            sapiens].
ACCESSION   XP_011535427
VERSION     XP_011535427.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537125.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..646
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..646
                     /product="coiled-coil domain-containing protein 175
                     isoform X4"
                     /calculated_mol_wt=75454
     Region          112..>391
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <220..>598
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     CDS             1..646
                     /gene="CCDC175"
                     /gene_synonym="C14orf38; c14_5395"
                     /coded_by="XM_011537125.3:38..1978"
                     /db_xref="GeneID:729665"
                     /db_xref="HGNC:HGNC:19847"
ORIGIN      
        1 malspwtpgl gageklvqaa avstgpslel ctlpstlgss vavealeqlf vveqslqsdy
       61 fkcneeakif lkdiavavkk leemrkatid lleiesmeln klyylletlp nsikreleec
      121 vrdarrlnlf eintikmrit rteneiellk kkitdltkyn ealgekqeel arkharfvls
      181 lnqtmekkat ttvyinetyt kinlkredia lqkkciqeae elmekeraey lirkqeltaq
      241 inefentrev krmetyqkkk eldklqtkms kiketvtvsa avlsdhnlei arlhesiryw
      301 eqevselkkd laileaklcf ftdnkekldd isndeknefl nkikqlvetl haarmeykdl
      361 rekmktlarq ykivlseeek aflqkqkihd enqkqltfis qkeyflsqkr vdiknmeegl
      421 itlqelqqat ktvyqqqiki lsanleresq rcvitqwkma clrkkharwt akikaeiqai
      481 tekiqnaevr riellnetsf rqqeisgfva qieklttelk eeekafvnke kmlmkelsky
      541 eeifvketqi nkekeeelve ylpqlqvaeq eykekrrkle elsniitdde rrdmgirrpg
      601 pkvterttmg tkivywlakt nmgigikiac vkmghsygtp icsnve
//
LOCUS       XP_047287702             610 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 175 isoform X5 [Homo
            sapiens].
ACCESSION   XP_047287702
VERSION     XP_047287702.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431746.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..610
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..610
                     /product="coiled-coil domain-containing protein 175
                     isoform X5"
                     /calculated_mol_wt=72795
     Region          32..>412
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          <287..554
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..610
                     /gene="CCDC175"
                     /gene_synonym="C14orf38; c14_5395"
                     /coded_by="XM_047431746.1:148..1980"
                     /db_xref="GeneID:729665"
                     /db_xref="HGNC:HGNC:19847"
ORIGIN      
        1 mekkatttvy inetytkinl kredialqkk ciqeaeelme keraeylirk qeltaqinef
       61 entrevkrme tyqkkkeldk lqtkmskike tvtvsaavls dhnleiarlh esiryweqev
      121 selkkdlail eaklcfftdn keklddisnd ekneflnkik qlvetlhaar meykdlrekm
      181 ktlarqykiv lseeekaflq kqkihdenqk qltfisqkey flsqkrvdik nmeeglitlq
      241 elqqatktvy qqqikilsan leresqrcvi tqwkmaclrk kharwtakik aeiqaiteki
      301 qnaevrriel lnetsfrqqe isgfvaqiek lttelkeeek afvnkekmlm kelskyeeif
      361 vketqinkek eeelveylpq lqvaeqeyke krrkleelsn iitaqrqeed llnnhiflft
      421 rdfsryisnm qedvkqelqq lrdqeskknk dhfetlknle ngfyindqka dllllenkkl
      481 keyilylknn iekyregqea lmhtssdlsr qliaqeaqyk dlwaefqttv kilvdngeet
      541 lqdinnltdk lrerdekmqh vstwlrgsle glrllveqes pmdllkkkkh irtrvhfpvv
      601 kctekntltk
//
LOCUS       XP_047287703             610 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 175 isoform X5 [Homo
            sapiens].
ACCESSION   XP_047287703
VERSION     XP_047287703.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431747.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..610
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..610
                     /product="coiled-coil domain-containing protein 175
                     isoform X5"
                     /calculated_mol_wt=72795
     Region          32..>412
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          <287..554
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..610
                     /gene="CCDC175"
                     /gene_synonym="C14orf38; c14_5395"
                     /coded_by="XM_047431747.1:1395..3227"
                     /db_xref="GeneID:729665"
                     /db_xref="HGNC:HGNC:19847"
ORIGIN      
        1 mekkatttvy inetytkinl kredialqkk ciqeaeelme keraeylirk qeltaqinef
       61 entrevkrme tyqkkkeldk lqtkmskike tvtvsaavls dhnleiarlh esiryweqev
      121 selkkdlail eaklcfftdn keklddisnd ekneflnkik qlvetlhaar meykdlrekm
      181 ktlarqykiv lseeekaflq kqkihdenqk qltfisqkey flsqkrvdik nmeeglitlq
      241 elqqatktvy qqqikilsan leresqrcvi tqwkmaclrk kharwtakik aeiqaiteki
      301 qnaevrriel lnetsfrqqe isgfvaqiek lttelkeeek afvnkekmlm kelskyeeif
      361 vketqinkek eeelveylpq lqvaeqeyke krrkleelsn iitaqrqeed llnnhiflft
      421 rdfsryisnm qedvkqelqq lrdqeskknk dhfetlknle ngfyindqka dllllenkkl
      481 keyilylknn iekyregqea lmhtssdlsr qliaqeaqyk dlwaefqttv kilvdngeet
      541 lqdinnltdk lrerdekmqh vstwlrgsle glrllveqes pmdllkkkkh irtrvhfpvv
      601 kctekntltk
//
LOCUS       XP_047287704             609 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 175 isoform X6 [Homo
            sapiens].
ACCESSION   XP_047287704
VERSION     XP_047287704.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431748.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..609
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..609
                     /product="coiled-coil domain-containing protein 175
                     isoform X6"
                     /calculated_mol_wt=71550
     Region          <131..>391
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <236..585
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..609
                     /gene="CCDC175"
                     /gene_synonym="C14orf38; c14_5395"
                     /coded_by="XM_047431748.1:38..1867"
                     /db_xref="GeneID:729665"
                     /db_xref="HGNC:HGNC:19847"
ORIGIN      
        1 malspwtpgl gageklvqaa avstgpslel ctlpstlgss vavealeqlf vveqslqsdy
       61 fkcneeakif lkdiavavkk leemrkatid lleiesmeln klyylletlp nsikreleec
      121 vrdarrlnlf eintikmrit rteneiellk kkitdltkyn ealgekqeel arkharfvls
      181 lnqtmekkat ttvyinetyt kinlkredia lqkkciqeae elmekeraey lirkqeltaq
      241 inefentrev krmetyqkkk eldklqtkms kiketvtvsa avlsdhnlei arlhesiryw
      301 eqevselkkd laileaklcf ftdnkekldd isndeknefl nkikqlvetl haarmeykdl
      361 rekmktlarq ykivlseeek aflqkqkihd enqkqltfis qkeyflsqkr vdiknmeegl
      421 itlqelqqat ktvyqqqiki lsanleresq rcvitqwkma clrkkharwt akikaeiqai
      481 tekiqnaevr riellnetsf rqqeisgfva qieklttelk eeekafvnke kmlmkelsky
      541 eeifvketqi nkekeeelve ylpqlqvaeq eykekrrkle elsniitgrc ktrittitrs
      601 rkqkkqrsf
//
LOCUS       XP_047287705             594 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 175 isoform X7 [Homo
            sapiens].
ACCESSION   XP_047287705
VERSION     XP_047287705.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431749.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..594
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..594
                     /product="coiled-coil domain-containing protein 175
                     isoform X7"
                     /calculated_mol_wt=69782
     Region          <131..>391
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <236..585
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..594
                     /gene="CCDC175"
                     /gene_synonym="C14orf38; c14_5395"
                     /coded_by="XM_047431749.1:38..1822"
                     /db_xref="GeneID:729665"
                     /db_xref="HGNC:HGNC:19847"
ORIGIN      
        1 malspwtpgl gageklvqaa avstgpslel ctlpstlgss vavealeqlf vveqslqsdy
       61 fkcneeakif lkdiavavkk leemrkatid lleiesmeln klyylletlp nsikreleec
      121 vrdarrlnlf eintikmrit rteneiellk kkitdltkyn ealgekqeel arkharfvls
      181 lnqtmekkat ttvyinetyt kinlkredia lqkkciqeae elmekeraey lirkqeltaq
      241 inefentrev krmetyqkkk eldklqtkms kiketvtvsa avlsdhnlei arlhesiryw
      301 eqevselkkd laileaklcf ftdnkekldd isndeknefl nkikqlvetl haarmeykdl
      361 rekmktlarq ykivlseeek aflqkqkihd enqkqltfis qkeyflsqkr vdiknmeegl
      421 itlqelqqat ktvyqqqiki lsanleresq rcvitqwkma clrkkharwt akikaeiqai
      481 tekiqnaevr riellnetsf rqqeisgfva qieklttelk eeekafvnke kmlmkelsky
      541 eeifvketqi nkekeeelve ylpqlqvaeq eykekrrkle elsniitvyf ilee
//
LOCUS       XP_047287706             567 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 175 isoform X8 [Homo
            sapiens].
ACCESSION   XP_047287706
VERSION     XP_047287706.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431750.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..567
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..567
                     /product="coiled-coil domain-containing protein 175
                     isoform X8"
                     /calculated_mol_wt=66119
     Region          112..>391
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <314..>558
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     CDS             1..567
                     /gene="CCDC175"
                     /gene_synonym="C14orf38; c14_5395"
                     /coded_by="XM_047431750.1:38..1741"
                     /db_xref="GeneID:729665"
                     /db_xref="HGNC:HGNC:19847"
ORIGIN      
        1 malspwtpgl gageklvqaa avstgpslel ctlpstlgss vavealeqlf vveqslqsdy
       61 fkcneeakif lkdiavavkk leemrkatid lleiesmeln klyylletlp nsikreleec
      121 vrdarrlnlf eintikmrit rteneiellk kkitdltkyn ealgekqeel arkharfvls
      181 lnqtmekkat ttvyinetyt kinlkredia lqkkciqeae elmekeraey lirkqeltaq
      241 inefentrev krmetyqkkk eldklqtkms kiketvtvsa avlsdhnlei arlhesiryw
      301 eqevselkkd laileaklcf ftdnkekldd isndeknefl nkikqlvetl haarmeykdl
      361 rekmktlarq ykivlseeek aflqkqkihd enqkqltfis qkeyflsqkr vdiknmeegl
      421 itlqelqqat ktvyqqqiki lsanleresq rcvitqwkma clrkkharwt akikaeiqai
      481 tekiqnaevr riellnetsf rqqeisgfva qieklttelk eeekafvnke kmlmkelsky
      541 eesetmrkdl egsedrvnlt gcptptt
//
LOCUS       XP_011535432             555 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 175 isoform X9 [Homo
            sapiens].
ACCESSION   XP_011535432
VERSION     XP_011535432.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537130.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..555
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..555
                     /product="coiled-coil domain-containing protein 175
                     isoform X9"
                     /calculated_mol_wt=64533
     Region          112..>391
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <314..>543
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     CDS             1..555
                     /gene="CCDC175"
                     /gene_synonym="C14orf38; c14_5395"
                     /coded_by="XM_011537130.3:38..1705"
                     /db_xref="GeneID:729665"
                     /db_xref="HGNC:HGNC:19847"
ORIGIN      
        1 malspwtpgl gageklvqaa avstgpslel ctlpstlgss vavealeqlf vveqslqsdy
       61 fkcneeakif lkdiavavkk leemrkatid lleiesmeln klyylletlp nsikreleec
      121 vrdarrlnlf eintikmrit rteneiellk kkitdltkyn ealgekqeel arkharfvls
      181 lnqtmekkat ttvyinetyt kinlkredia lqkkciqeae elmekeraey lirkqeltaq
      241 inefentrev krmetyqkkk eldklqtkms kiketvtvsa avlsdhnlei arlhesiryw
      301 eqevselkkd laileaklcf ftdnkekldd isndeknefl nkikqlvetl haarmeykdl
      361 rekmktlarq ykivlseeek aflqkqkihd enqkqltfis qkeyflsqkr vdiknmeegl
      421 itlqelqqat ktvyqqqiki lsanleresq rcvitqwkma clrkkharwt akikaeiqai
      481 tekiqnaevr riellnetsf rqqeisgfva qieklttelk eeekafvnke kmlmkelsky
      541 egdggpgset gachh
//
LOCUS       XP_047287707             397 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 175 isoform X10 [Homo
            sapiens].
ACCESSION   XP_047287707
VERSION     XP_047287707.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431751.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..397
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..397
                     /product="coiled-coil domain-containing protein 175
                     isoform X10"
                     /calculated_mol_wt=45754
     Region          45..>351
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     CDS             1..397
                     /gene="CCDC175"
                     /gene_synonym="C14orf38; c14_5395"
                     /coded_by="XM_047431751.1:38..1231"
                     /db_xref="GeneID:729665"
                     /db_xref="HGNC:HGNC:19847"
ORIGIN      
        1 malspwtpgl gageklvqaa avstgpslel ctlpstlgss vavealeqlf vveqslqsdy
       61 fkcneeakif lkdiavavkk leemrkatid lleiesmeln klyylletlp nsikreleec
      121 vrdarrlnlf eintikmrit rteneiellk kkitdltkyn ealgekqeel arkharfvls
      181 lnqtmekkat ttvyinetyt kinlkredia lqkkciqeae elmekeraey lirkqeltaq
      241 inefentrev krmetyqkkk eldklqtkms kiketvtvsa avlsdhnlei arlhesiryw
      301 eqevselkkd laileaklcf ftdnkekldd isndeknefl nkikqkseta diyfserils
      361 vtkesrhqky grrthhtpgt stsnknsvsa tnqnpec
//
LOCUS       XP_047287708             422 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase VRK1 isoform X1 [Homo sapiens].
ACCESSION   XP_047287708
VERSION     XP_047287708.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431752.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..422
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..422
                     /product="serine/threonine-protein kinase VRK1 isoform X1"
                     /calculated_mol_wt=48144
     Region          28..328
                     /region_name="STKc_VRK1"
                     /note="Catalytic domain of the Serine/Threonine protein
                     kinase, Vaccinia Related Kinase 1; cd14122"
                     /db_xref="CDD:271024"
     Site            order(45..49,53,71,73,113,133..136,139,141,179,181,
                     183..184,186,199,202,225..228)
                     /site_type="active"
                     /db_xref="CDD:271024"
     Site            order(45..49,53,71,73,113,133..136,139,179,181,183..184,
                     186,199)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271024"
     Site            order(49,139,141,179,181,183,202,225..228)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:271024"
     Site            198..228
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:271024"
     CDS             1..422
                     /gene="VRK1"
                     /gene_synonym="HMNR10; PCH1; PCH1A"
                     /coded_by="XM_047431752.1:26298..27566"
                     /db_xref="GeneID:7443"
                     /db_xref="HGNC:HGNC:12718"
                     /db_xref="MIM:602168"
ORIGIN      
        1 mkmprvkaaq agrqssakrh laeqfavgei itdmakkewk vglpigqggf gciyladmns
       61 sesvgsdapc vvkvepsdng plftelkfyq raakpeqiqk wirtrklkyl gvpkywgsgl
      121 hdkngksyrf mimdrfgsdl qkiyeanakr fsrktvlqls lrildileyi heheyvhgdi
      181 kasnlllnyk npdqvylvdy glayrycpeg vhkeykedpk rchdgtieft sidahngvap
      241 srrgdleilg ycmiqwltgh lpwednlkdp kyvrdskiry reniaslmdk cfpeknkpge
      301 iakymetvkl ldytekplye nlrdillqgl kaigskddgk ldlsvvengg lkaktitkkr
      361 kkeieeskep gvedtewsnt qteeaiqtrs eesqgaihrs msqpeassss ydssrtrkrv
      421 qk
//
LOCUS       XP_047287709             422 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase VRK1 isoform X1 [Homo sapiens].
ACCESSION   XP_047287709
VERSION     XP_047287709.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431753.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..422
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..422
                     /product="serine/threonine-protein kinase VRK1 isoform X1"
                     /calculated_mol_wt=48144
     Region          28..328
                     /region_name="STKc_VRK1"
                     /note="Catalytic domain of the Serine/Threonine protein
                     kinase, Vaccinia Related Kinase 1; cd14122"
                     /db_xref="CDD:271024"
     Site            order(45..49,53,71,73,113,133..136,139,141,179,181,
                     183..184,186,199,202,225..228)
                     /site_type="active"
                     /db_xref="CDD:271024"
     Site            order(45..49,53,71,73,113,133..136,139,179,181,183..184,
                     186,199)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271024"
     Site            order(49,139,141,179,181,183,202,225..228)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:271024"
     Site            198..228
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:271024"
     CDS             1..422
                     /gene="VRK1"
                     /gene_synonym="HMNR10; PCH1; PCH1A"
                     /coded_by="XM_047431753.1:25178..26446"
                     /db_xref="GeneID:7443"
                     /db_xref="HGNC:HGNC:12718"
                     /db_xref="MIM:602168"
ORIGIN      
        1 mkmprvkaaq agrqssakrh laeqfavgei itdmakkewk vglpigqggf gciyladmns
       61 sesvgsdapc vvkvepsdng plftelkfyq raakpeqiqk wirtrklkyl gvpkywgsgl
      121 hdkngksyrf mimdrfgsdl qkiyeanakr fsrktvlqls lrildileyi heheyvhgdi
      181 kasnlllnyk npdqvylvdy glayrycpeg vhkeykedpk rchdgtieft sidahngvap
      241 srrgdleilg ycmiqwltgh lpwednlkdp kyvrdskiry reniaslmdk cfpeknkpge
      301 iakymetvkl ldytekplye nlrdillqgl kaigskddgk ldlsvvengg lkaktitkkr
      361 kkeieeskep gvedtewsnt qteeaiqtrs eesqgaihrs msqpeassss ydssrtrkrv
      421 qk
//
LOCUS       XP_047287710             421 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase VRK1 isoform X2 [Homo sapiens].
ACCESSION   XP_047287710
VERSION     XP_047287710.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431754.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..421
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..421
                     /product="serine/threonine-protein kinase VRK1 isoform X2"
                     /calculated_mol_wt=48016
     Region          28..328
                     /region_name="STKc_VRK1"
                     /note="Catalytic domain of the Serine/Threonine protein
                     kinase, Vaccinia Related Kinase 1; cd14122"
                     /db_xref="CDD:271024"
     Site            order(45..49,53,71,73,113,133..136,139,141,179,181,
                     183..184,186,199,202,225..228)
                     /site_type="active"
                     /db_xref="CDD:271024"
     Site            order(45..49,53,71,73,113,133..136,139,179,181,183..184,
                     186,199)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271024"
     Site            order(49,139,141,179,181,183,202,225..228)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:271024"
     Site            198..228
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:271024"
     CDS             1..421
                     /gene="VRK1"
                     /gene_synonym="HMNR10; PCH1; PCH1A"
                     /coded_by="XM_047431754.1:26298..27563"
                     /db_xref="GeneID:7443"
                     /db_xref="HGNC:HGNC:12718"
                     /db_xref="MIM:602168"
ORIGIN      
        1 mkmprvkaaq agrqssakrh laeqfavgei itdmakkewk vglpigqggf gciyladmns
       61 sesvgsdapc vvkvepsdng plftelkfyq raakpeqiqk wirtrklkyl gvpkywgsgl
      121 hdkngksyrf mimdrfgsdl qkiyeanakr fsrktvlqls lrildileyi heheyvhgdi
      181 kasnlllnyk npdqvylvdy glayrycpeg vhkeykedpk rchdgtieft sidahngvap
      241 srrgdleilg ycmiqwltgh lpwednlkdp kyvrdskiry reniaslmdk cfpeknkpge
      301 iakymetvkl ldytekplye nlrdillqgl kaigskddgk ldlsvvengg lkaktitkrk
      361 keieeskepg vedtewsntq teeaiqtrse esqgaihrsm sqpeassssy dssrtrkrvq
      421 k
//
LOCUS       XP_047287711             419 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase VRK1 isoform X3 [Homo sapiens].
ACCESSION   XP_047287711
VERSION     XP_047287711.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431755.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..419
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..419
                     /product="serine/threonine-protein kinase VRK1 isoform X3"
                     /calculated_mol_wt=47756
     Region          26..326
                     /region_name="STKc_VRK1"
                     /note="Catalytic domain of the Serine/Threonine protein
                     kinase, Vaccinia Related Kinase 1; cd14122"
                     /db_xref="CDD:271024"
     Site            order(43..47,51,69,71,111,131..134,137,139,177,179,
                     181..182,184,197,200,223..226)
                     /site_type="active"
                     /db_xref="CDD:271024"
     Site            order(43..47,51,69,71,111,131..134,137,177,179,181..182,
                     184,197)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271024"
     Site            order(47,137,139,177,179,181,200,223..226)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:271024"
     Site            196..226
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:271024"
     CDS             1..419
                     /gene="VRK1"
                     /gene_synonym="HMNR10; PCH1; PCH1A"
                     /coded_by="XM_047431755.1:72..1331"
                     /db_xref="GeneID:7443"
                     /db_xref="HGNC:HGNC:12718"
                     /db_xref="MIM:602168"
ORIGIN      
        1 mprvkaaqag rqssakrhla eqfavgeiit dmakkewkvg lpigqggfgc iyladmnsse
       61 svgsdapcvv kvepsdngpl ftelkfyqra akpeqiqkwi rtrklkylgv pkywgsglhd
      121 kngksyrfmi mdrfgsdlqk iyeanakrfs rktvlqlslr ildileyihe heyvhgdika
      181 snlllnyknp dqvylvdygl ayrycpegvh keykedpkrc hdgtieftsi dahngvapsr
      241 rgdleilgyc miqwltghlp wednlkdpky vrdskiryre niaslmdkcf peknkpgeia
      301 kymetvklld ytekplyenl rdillqglka igskddgkld lsvvengglk aktitkrkke
      361 ieeskepgve dtewsntqte eaiqtrsees qgaihrsmsq peassssyds srtrkrvqk
//
LOCUS       XP_016877114             398 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase VRK1 isoform X4 [Homo sapiens].
ACCESSION   XP_016877114
VERSION     XP_016877114.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021625.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..398
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..398
                     /product="serine/threonine-protein kinase VRK1 isoform X4"
                     /calculated_mol_wt=45604
     Region          28..328
                     /region_name="STKc_VRK1"
                     /note="Catalytic domain of the Serine/Threonine protein
                     kinase, Vaccinia Related Kinase 1; cd14122"
                     /db_xref="CDD:271024"
     Site            order(45..49,53,71,73,113,133..136,139,141,179,181,
                     183..184,186,199,202,225..228)
                     /site_type="active"
                     /db_xref="CDD:271024"
     Site            order(45..49,53,71,73,113,133..136,139,179,181,183..184,
                     186,199)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271024"
     Site            order(49,139,141,179,181,183,202,225..228)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:271024"
     Site            198..228
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:271024"
     CDS             1..398
                     /gene="VRK1"
                     /gene_synonym="HMNR10; PCH1; PCH1A"
                     /coded_by="XM_017021625.2:26298..27494"
                     /db_xref="GeneID:7443"
                     /db_xref="HGNC:HGNC:12718"
                     /db_xref="MIM:602168"
ORIGIN      
        1 mkmprvkaaq agrqssakrh laeqfavgei itdmakkewk vglpigqggf gciyladmns
       61 sesvgsdapc vvkvepsdng plftelkfyq raakpeqiqk wirtrklkyl gvpkywgsgl
      121 hdkngksyrf mimdrfgsdl qkiyeanakr fsrktvlqls lrildileyi heheyvhgdi
      181 kasnlllnyk npdqvylvdy glayrycpeg vhkeykedpk rchdgtieft sidahngvap
      241 srrgdleilg ycmiqwltgh lpwednlkdp kyvrdskiry reniaslmdk cfpeknkpge
      301 iakymetvkl ldytekplye nlrdillqgl kaigskddgk ldlsvvengg lkaktitkkr
      361 kkeieeskep gvedtewsnt qteeaiqtrs rtrkrvqk
//
LOCUS       XP_047287712             397 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase VRK1 isoform X5 [Homo sapiens].
ACCESSION   XP_047287712
VERSION     XP_047287712.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431756.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..397
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..397
                     /product="serine/threonine-protein kinase VRK1 isoform X5"
                     /calculated_mol_wt=45476
     Region          28..328
                     /region_name="STKc_VRK1"
                     /note="Catalytic domain of the Serine/Threonine protein
                     kinase, Vaccinia Related Kinase 1; cd14122"
                     /db_xref="CDD:271024"
     Site            order(45..49,53,71,73,113,133..136,139,141,179,181,
                     183..184,186,199,202,225..228)
                     /site_type="active"
                     /db_xref="CDD:271024"
     Site            order(45..49,53,71,73,113,133..136,139,179,181,183..184,
                     186,199)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271024"
     Site            order(49,139,141,179,181,183,202,225..228)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:271024"
     Site            198..228
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:271024"
     CDS             1..397
                     /gene="VRK1"
                     /gene_synonym="HMNR10; PCH1; PCH1A"
                     /coded_by="XM_047431756.1:26298..27491"
                     /db_xref="GeneID:7443"
                     /db_xref="HGNC:HGNC:12718"
                     /db_xref="MIM:602168"
ORIGIN      
        1 mkmprvkaaq agrqssakrh laeqfavgei itdmakkewk vglpigqggf gciyladmns
       61 sesvgsdapc vvkvepsdng plftelkfyq raakpeqiqk wirtrklkyl gvpkywgsgl
      121 hdkngksyrf mimdrfgsdl qkiyeanakr fsrktvlqls lrildileyi heheyvhgdi
      181 kasnlllnyk npdqvylvdy glayrycpeg vhkeykedpk rchdgtieft sidahngvap
      241 srrgdleilg ycmiqwltgh lpwednlkdp kyvrdskiry reniaslmdk cfpeknkpge
      301 iakymetvkl ldytekplye nlrdillqgl kaigskddgk ldlsvvengg lkaktitkrk
      361 keieeskepg vedtewsntq teeaiqtrsr trkrvqk
//
LOCUS       XP_016877115             244 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase VRK1 isoform X6 [Homo sapiens].
ACCESSION   XP_016877115
VERSION     XP_016877115.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021626.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..244
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..244
                     /product="serine/threonine-protein kinase VRK1 isoform X6"
                     /calculated_mol_wt=27733
     Region          26..>236
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Site            order(43..46,49,51,69,71,111,131..134,177,181..182,184,
                     196..197)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271024"
     CDS             1..244
                     /gene="VRK1"
                     /gene_synonym="HMNR10; PCH1; PCH1A"
                     /coded_by="XM_017021626.3:72..806"
                     /db_xref="GeneID:7443"
                     /db_xref="HGNC:HGNC:12718"
                     /db_xref="MIM:602168"
ORIGIN      
        1 mprvkaaqag rqssakrhla eqfavgeiit dmakkewkvg lpigqggfgc iyladmnsse
       61 svgsdapcvv kvepsdngpl ftelkfyqra akpeqiqkwi rtrklkylgv pkywgsglhd
      121 kngksyrfmi mdrfgsdlqk iyeanakrfs rktvlqlslr ildileyihe heyvhgdika
      181 snlllnyknp dqvylvdygl ayrycpegvh keykedpkrc hdgtieftsi dahngvdtek
      241 ilqv
//
LOCUS       XP_016877116             471 aa            linear   PRI 05-AUG-2025
DEFINITION  tryptophan--tRNA ligase, cytoplasmic isoform X1 [Homo sapiens].
ACCESSION   XP_016877116
VERSION     XP_016877116.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021627.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..471
                     /product="tryptophan--tRNA ligase, cytoplasmic isoform X1"
                     /calculated_mol_wt=53035
     Region          12..61
                     /region_name="WEPRS_RNA"
                     /note="WEPRS_RNA binding domain. This short RNA-binding
                     domain is found in several higher eukaryote aminoacyl-tRNA
                     synthetases (aaRSs). It is found in multiple copies in
                     eukaryotic bifunctional glutamyl-prolyl-tRNA synthetases
                     (EPRS) in a region that separates...; cd00936"
                     /db_xref="CDD:238473"
     Site            order(19,21,24,29,34,38,46,54)
                     /site_type="other"
                     /note="tRNA binding site [nucleotide binding]"
                     /db_xref="CDD:238473"
     Region          85..466
                     /region_name="PLN02486"
                     /note="aminoacyl-tRNA ligase"
                     /db_xref="CDD:178104"
     Site            order(159..163,170,172..173,176,194,199,237,280,284,287,
                     307,309..310,312..313,316,339,349..350,352)
                     /site_type="active"
                     /db_xref="CDD:173903"
     Site            170..173
                     /site_type="other"
                     /note="HIGH motif"
                     /db_xref="CDD:173903"
     Site            order(198,201..202,247..248,250..252,255..256,258..261,
                     263..264,276,278..279,282..283)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:173903"
     Site            349..353
                     /site_type="other"
                     /note="KMSKS motif"
                     /db_xref="CDD:173903"
     CDS             1..471
                     /gene="WARS1"
                     /gene_synonym="GAMMA-2; HMN9; HMND9; IFI53; IFP53;
                     NEDMSBA; WARS"
                     /coded_by="XM_017021627.3:266..1681"
                     /db_xref="GeneID:7453"
                     /db_xref="HGNC:HGNC:12729"
                     /db_xref="MIM:191050"
ORIGIN      
        1 mpnsepasll elfnsiatqg elvrslkagn askdeidsav kmlvslkmsy kaaagedyka
       61 dcppgnpapt snhgpdatea eedfvdpwtv qtssakgidy dklivrfgss kidkelinri
      121 eratgqrphh flrrgiffsh rdmnqvlday enkkpfylyt grgpsseamh vghlipfift
      181 kwlqdvfnvp lviqmtddek ylwkdltldq aysyavenak diiacgfdin ktfifsdldy
      241 mgmssgfykn vvkiqkhvtf nqvkgifgft dsdcigkisf paiqaapsfs nsfpqifrdr
      301 tdiqclipca idqdpyfrmt rdvaprigyp kpallhstff palqgaqtkm sasdpnssif
      361 ltdtakqikt kvnkhafsgg rdtieehrqf ggncdvdvsf myltffledd dkleqirkdy
      421 tsgamltgel kkalievlqp liaehqarrk evtdeivkef mtprklsfdf q
//
LOCUS       XP_047287713             471 aa            linear   PRI 05-AUG-2025
DEFINITION  tryptophan--tRNA ligase, cytoplasmic isoform X1 [Homo sapiens].
ACCESSION   XP_047287713
VERSION     XP_047287713.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431757.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..471
                     /product="tryptophan--tRNA ligase, cytoplasmic isoform X1"
                     /calculated_mol_wt=53035
     Region          12..61
                     /region_name="WEPRS_RNA"
                     /note="WEPRS_RNA binding domain. This short RNA-binding
                     domain is found in several higher eukaryote aminoacyl-tRNA
                     synthetases (aaRSs). It is found in multiple copies in
                     eukaryotic bifunctional glutamyl-prolyl-tRNA synthetases
                     (EPRS) in a region that separates...; cd00936"
                     /db_xref="CDD:238473"
     Site            order(19,21,24,29,34,38,46,54)
                     /site_type="other"
                     /note="tRNA binding site [nucleotide binding]"
                     /db_xref="CDD:238473"
     Region          85..466
                     /region_name="PLN02486"
                     /note="aminoacyl-tRNA ligase"
                     /db_xref="CDD:178104"
     Site            order(159..163,170,172..173,176,194,199,237,280,284,287,
                     307,309..310,312..313,316,339,349..350,352)
                     /site_type="active"
                     /db_xref="CDD:173903"
     Site            170..173
                     /site_type="other"
                     /note="HIGH motif"
                     /db_xref="CDD:173903"
     Site            order(198,201..202,247..248,250..252,255..256,258..261,
                     263..264,276,278..279,282..283)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:173903"
     Site            349..353
                     /site_type="other"
                     /note="KMSKS motif"
                     /db_xref="CDD:173903"
     CDS             1..471
                     /gene="WARS1"
                     /gene_synonym="GAMMA-2; HMN9; HMND9; IFI53; IFP53;
                     NEDMSBA; WARS"
                     /coded_by="XM_047431757.1:302..1717"
                     /db_xref="GeneID:7453"
                     /db_xref="HGNC:HGNC:12729"
                     /db_xref="MIM:191050"
ORIGIN      
        1 mpnsepasll elfnsiatqg elvrslkagn askdeidsav kmlvslkmsy kaaagedyka
       61 dcppgnpapt snhgpdatea eedfvdpwtv qtssakgidy dklivrfgss kidkelinri
      121 eratgqrphh flrrgiffsh rdmnqvlday enkkpfylyt grgpsseamh vghlipfift
      181 kwlqdvfnvp lviqmtddek ylwkdltldq aysyavenak diiacgfdin ktfifsdldy
      241 mgmssgfykn vvkiqkhvtf nqvkgifgft dsdcigkisf paiqaapsfs nsfpqifrdr
      301 tdiqclipca idqdpyfrmt rdvaprigyp kpallhstff palqgaqtkm sasdpnssif
      361 ltdtakqikt kvnkhafsgg rdtieehrqf ggncdvdvsf myltffledd dkleqirkdy
      421 tsgamltgel kkalievlqp liaehqarrk evtdeivkef mtprklsfdf q
//
LOCUS       XP_047287714             471 aa            linear   PRI 05-AUG-2025
DEFINITION  tryptophan--tRNA ligase, cytoplasmic isoform X1 [Homo sapiens].
ACCESSION   XP_047287714
VERSION     XP_047287714.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431758.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..471
                     /product="tryptophan--tRNA ligase, cytoplasmic isoform X1"
                     /calculated_mol_wt=53035
     Region          12..61
                     /region_name="WEPRS_RNA"
                     /note="WEPRS_RNA binding domain. This short RNA-binding
                     domain is found in several higher eukaryote aminoacyl-tRNA
                     synthetases (aaRSs). It is found in multiple copies in
                     eukaryotic bifunctional glutamyl-prolyl-tRNA synthetases
                     (EPRS) in a region that separates...; cd00936"
                     /db_xref="CDD:238473"
     Site            order(19,21,24,29,34,38,46,54)
                     /site_type="other"
                     /note="tRNA binding site [nucleotide binding]"
                     /db_xref="CDD:238473"
     Region          85..466
                     /region_name="PLN02486"
                     /note="aminoacyl-tRNA ligase"
                     /db_xref="CDD:178104"
     Site            order(159..163,170,172..173,176,194,199,237,280,284,287,
                     307,309..310,312..313,316,339,349..350,352)
                     /site_type="active"
                     /db_xref="CDD:173903"
     Site            170..173
                     /site_type="other"
                     /note="HIGH motif"
                     /db_xref="CDD:173903"
     Site            order(198,201..202,247..248,250..252,255..256,258..261,
                     263..264,276,278..279,282..283)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:173903"
     Site            349..353
                     /site_type="other"
                     /note="KMSKS motif"
                     /db_xref="CDD:173903"
     CDS             1..471
                     /gene="WARS1"
                     /gene_synonym="GAMMA-2; HMN9; HMND9; IFI53; IFP53;
                     NEDMSBA; WARS"
                     /coded_by="XM_047431758.1:178..1593"
                     /db_xref="GeneID:7453"
                     /db_xref="HGNC:HGNC:12729"
                     /db_xref="MIM:191050"
ORIGIN      
        1 mpnsepasll elfnsiatqg elvrslkagn askdeidsav kmlvslkmsy kaaagedyka
       61 dcppgnpapt snhgpdatea eedfvdpwtv qtssakgidy dklivrfgss kidkelinri
      121 eratgqrphh flrrgiffsh rdmnqvlday enkkpfylyt grgpsseamh vghlipfift
      181 kwlqdvfnvp lviqmtddek ylwkdltldq aysyavenak diiacgfdin ktfifsdldy
      241 mgmssgfykn vvkiqkhvtf nqvkgifgft dsdcigkisf paiqaapsfs nsfpqifrdr
      301 tdiqclipca idqdpyfrmt rdvaprigyp kpallhstff palqgaqtkm sasdpnssif
      361 ltdtakqikt kvnkhafsgg rdtieehrqf ggncdvdvsf myltffledd dkleqirkdy
      421 tsgamltgel kkalievlqp liaehqarrk evtdeivkef mtprklsfdf q
//
LOCUS       XP_047287715             471 aa            linear   PRI 05-AUG-2025
DEFINITION  tryptophan--tRNA ligase, cytoplasmic isoform X1 [Homo sapiens].
ACCESSION   XP_047287715
VERSION     XP_047287715.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431759.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..471
                     /product="tryptophan--tRNA ligase, cytoplasmic isoform X1"
                     /calculated_mol_wt=53035
     Region          12..61
                     /region_name="WEPRS_RNA"
                     /note="WEPRS_RNA binding domain. This short RNA-binding
                     domain is found in several higher eukaryote aminoacyl-tRNA
                     synthetases (aaRSs). It is found in multiple copies in
                     eukaryotic bifunctional glutamyl-prolyl-tRNA synthetases
                     (EPRS) in a region that separates...; cd00936"
                     /db_xref="CDD:238473"
     Site            order(19,21,24,29,34,38,46,54)
                     /site_type="other"
                     /note="tRNA binding site [nucleotide binding]"
                     /db_xref="CDD:238473"
     Region          85..466
                     /region_name="PLN02486"
                     /note="aminoacyl-tRNA ligase"
                     /db_xref="CDD:178104"
     Site            order(159..163,170,172..173,176,194,199,237,280,284,287,
                     307,309..310,312..313,316,339,349..350,352)
                     /site_type="active"
                     /db_xref="CDD:173903"
     Site            170..173
                     /site_type="other"
                     /note="HIGH motif"
                     /db_xref="CDD:173903"
     Site            order(198,201..202,247..248,250..252,255..256,258..261,
                     263..264,276,278..279,282..283)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:173903"
     Site            349..353
                     /site_type="other"
                     /note="KMSKS motif"
                     /db_xref="CDD:173903"
     CDS             1..471
                     /gene="WARS1"
                     /gene_synonym="GAMMA-2; HMN9; HMND9; IFI53; IFP53;
                     NEDMSBA; WARS"
                     /coded_by="XM_047431759.1:351..1766"
                     /db_xref="GeneID:7453"
                     /db_xref="HGNC:HGNC:12729"
                     /db_xref="MIM:191050"
ORIGIN      
        1 mpnsepasll elfnsiatqg elvrslkagn askdeidsav kmlvslkmsy kaaagedyka
       61 dcppgnpapt snhgpdatea eedfvdpwtv qtssakgidy dklivrfgss kidkelinri
      121 eratgqrphh flrrgiffsh rdmnqvlday enkkpfylyt grgpsseamh vghlipfift
      181 kwlqdvfnvp lviqmtddek ylwkdltldq aysyavenak diiacgfdin ktfifsdldy
      241 mgmssgfykn vvkiqkhvtf nqvkgifgft dsdcigkisf paiqaapsfs nsfpqifrdr
      301 tdiqclipca idqdpyfrmt rdvaprigyp kpallhstff palqgaqtkm sasdpnssif
      361 ltdtakqikt kvnkhafsgg rdtieehrqf ggncdvdvsf myltffledd dkleqirkdy
      421 tsgamltgel kkalievlqp liaehqarrk evtdeivkef mtprklsfdf q
//
LOCUS       XP_024305475             471 aa            linear   PRI 05-AUG-2025
DEFINITION  tryptophan--tRNA ligase, cytoplasmic isoform X1 [Homo sapiens].
ACCESSION   XP_024305475
VERSION     XP_024305475.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449707.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..471
                     /product="tryptophan--tRNA ligase, cytoplasmic isoform X1"
                     /calculated_mol_wt=53035
     Region          12..61
                     /region_name="WEPRS_RNA"
                     /note="WEPRS_RNA binding domain. This short RNA-binding
                     domain is found in several higher eukaryote aminoacyl-tRNA
                     synthetases (aaRSs). It is found in multiple copies in
                     eukaryotic bifunctional glutamyl-prolyl-tRNA synthetases
                     (EPRS) in a region that separates...; cd00936"
                     /db_xref="CDD:238473"
     Site            order(19,21,24,29,34,38,46,54)
                     /site_type="other"
                     /note="tRNA binding site [nucleotide binding]"
                     /db_xref="CDD:238473"
     Region          85..466
                     /region_name="PLN02486"
                     /note="aminoacyl-tRNA ligase"
                     /db_xref="CDD:178104"
     Site            order(159..163,170,172..173,176,194,199,237,280,284,287,
                     307,309..310,312..313,316,339,349..350,352)
                     /site_type="active"
                     /db_xref="CDD:173903"
     Site            170..173
                     /site_type="other"
                     /note="HIGH motif"
                     /db_xref="CDD:173903"
     Site            order(198,201..202,247..248,250..252,255..256,258..261,
                     263..264,276,278..279,282..283)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:173903"
     Site            349..353
                     /site_type="other"
                     /note="KMSKS motif"
                     /db_xref="CDD:173903"
     CDS             1..471
                     /gene="WARS1"
                     /gene_synonym="GAMMA-2; HMN9; HMND9; IFI53; IFP53;
                     NEDMSBA; WARS"
                     /coded_by="XM_024449707.2:227..1642"
                     /db_xref="GeneID:7453"
                     /db_xref="HGNC:HGNC:12729"
                     /db_xref="MIM:191050"
ORIGIN      
        1 mpnsepasll elfnsiatqg elvrslkagn askdeidsav kmlvslkmsy kaaagedyka
       61 dcppgnpapt snhgpdatea eedfvdpwtv qtssakgidy dklivrfgss kidkelinri
      121 eratgqrphh flrrgiffsh rdmnqvlday enkkpfylyt grgpsseamh vghlipfift
      181 kwlqdvfnvp lviqmtddek ylwkdltldq aysyavenak diiacgfdin ktfifsdldy
      241 mgmssgfykn vvkiqkhvtf nqvkgifgft dsdcigkisf paiqaapsfs nsfpqifrdr
      301 tdiqclipca idqdpyfrmt rdvaprigyp kpallhstff palqgaqtkm sasdpnssif
      361 ltdtakqikt kvnkhafsgg rdtieehrqf ggncdvdvsf myltffledd dkleqirkdy
      421 tsgamltgel kkalievlqp liaehqarrk evtdeivkef mtprklsfdf q
//
LOCUS       XP_047287716             471 aa            linear   PRI 05-AUG-2025
DEFINITION  tryptophan--tRNA ligase, cytoplasmic isoform X1 [Homo sapiens].
ACCESSION   XP_047287716
VERSION     XP_047287716.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431760.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..471
                     /product="tryptophan--tRNA ligase, cytoplasmic isoform X1"
                     /calculated_mol_wt=53035
     Region          12..61
                     /region_name="WEPRS_RNA"
                     /note="WEPRS_RNA binding domain. This short RNA-binding
                     domain is found in several higher eukaryote aminoacyl-tRNA
                     synthetases (aaRSs). It is found in multiple copies in
                     eukaryotic bifunctional glutamyl-prolyl-tRNA synthetases
                     (EPRS) in a region that separates...; cd00936"
                     /db_xref="CDD:238473"
     Site            order(19,21,24,29,34,38,46,54)
                     /site_type="other"
                     /note="tRNA binding site [nucleotide binding]"
                     /db_xref="CDD:238473"
     Region          85..466
                     /region_name="PLN02486"
                     /note="aminoacyl-tRNA ligase"
                     /db_xref="CDD:178104"
     Site            order(159..163,170,172..173,176,194,199,237,280,284,287,
                     307,309..310,312..313,316,339,349..350,352)
                     /site_type="active"
                     /db_xref="CDD:173903"
     Site            170..173
                     /site_type="other"
                     /note="HIGH motif"
                     /db_xref="CDD:173903"
     Site            order(198,201..202,247..248,250..252,255..256,258..261,
                     263..264,276,278..279,282..283)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:173903"
     Site            349..353
                     /site_type="other"
                     /note="KMSKS motif"
                     /db_xref="CDD:173903"
     CDS             1..471
                     /gene="WARS1"
                     /gene_synonym="GAMMA-2; HMN9; HMND9; IFI53; IFP53;
                     NEDMSBA; WARS"
                     /coded_by="XM_047431760.1:248..1663"
                     /db_xref="GeneID:7453"
                     /db_xref="HGNC:HGNC:12729"
                     /db_xref="MIM:191050"
ORIGIN      
        1 mpnsepasll elfnsiatqg elvrslkagn askdeidsav kmlvslkmsy kaaagedyka
       61 dcppgnpapt snhgpdatea eedfvdpwtv qtssakgidy dklivrfgss kidkelinri
      121 eratgqrphh flrrgiffsh rdmnqvlday enkkpfylyt grgpsseamh vghlipfift
      181 kwlqdvfnvp lviqmtddek ylwkdltldq aysyavenak diiacgfdin ktfifsdldy
      241 mgmssgfykn vvkiqkhvtf nqvkgifgft dsdcigkisf paiqaapsfs nsfpqifrdr
      301 tdiqclipca idqdpyfrmt rdvaprigyp kpallhstff palqgaqtkm sasdpnssif
      361 ltdtakqikt kvnkhafsgg rdtieehrqf ggncdvdvsf myltffledd dkleqirkdy
      421 tsgamltgel kkalievlqp liaehqarrk evtdeivkef mtprklsfdf q
//
LOCUS       XP_047287717             471 aa            linear   PRI 05-AUG-2025
DEFINITION  tryptophan--tRNA ligase, cytoplasmic isoform X1 [Homo sapiens].
ACCESSION   XP_047287717
VERSION     XP_047287717.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431761.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..471
                     /product="tryptophan--tRNA ligase, cytoplasmic isoform X1"
                     /calculated_mol_wt=53035
     Region          12..61
                     /region_name="WEPRS_RNA"
                     /note="WEPRS_RNA binding domain. This short RNA-binding
                     domain is found in several higher eukaryote aminoacyl-tRNA
                     synthetases (aaRSs). It is found in multiple copies in
                     eukaryotic bifunctional glutamyl-prolyl-tRNA synthetases
                     (EPRS) in a region that separates...; cd00936"
                     /db_xref="CDD:238473"
     Site            order(19,21,24,29,34,38,46,54)
                     /site_type="other"
                     /note="tRNA binding site [nucleotide binding]"
                     /db_xref="CDD:238473"
     Region          85..466
                     /region_name="PLN02486"
                     /note="aminoacyl-tRNA ligase"
                     /db_xref="CDD:178104"
     Site            order(159..163,170,172..173,176,194,199,237,280,284,287,
                     307,309..310,312..313,316,339,349..350,352)
                     /site_type="active"
                     /db_xref="CDD:173903"
     Site            170..173
                     /site_type="other"
                     /note="HIGH motif"
                     /db_xref="CDD:173903"
     Site            order(198,201..202,247..248,250..252,255..256,258..261,
                     263..264,276,278..279,282..283)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:173903"
     Site            349..353
                     /site_type="other"
                     /note="KMSKS motif"
                     /db_xref="CDD:173903"
     CDS             1..471
                     /gene="WARS1"
                     /gene_synonym="GAMMA-2; HMN9; HMND9; IFI53; IFP53;
                     NEDMSBA; WARS"
                     /coded_by="XM_047431761.1:269..1684"
                     /db_xref="GeneID:7453"
                     /db_xref="HGNC:HGNC:12729"
                     /db_xref="MIM:191050"
ORIGIN      
        1 mpnsepasll elfnsiatqg elvrslkagn askdeidsav kmlvslkmsy kaaagedyka
       61 dcppgnpapt snhgpdatea eedfvdpwtv qtssakgidy dklivrfgss kidkelinri
      121 eratgqrphh flrrgiffsh rdmnqvlday enkkpfylyt grgpsseamh vghlipfift
      181 kwlqdvfnvp lviqmtddek ylwkdltldq aysyavenak diiacgfdin ktfifsdldy
      241 mgmssgfykn vvkiqkhvtf nqvkgifgft dsdcigkisf paiqaapsfs nsfpqifrdr
      301 tdiqclipca idqdpyfrmt rdvaprigyp kpallhstff palqgaqtkm sasdpnssif
      361 ltdtakqikt kvnkhafsgg rdtieehrqf ggncdvdvsf myltffledd dkleqirkdy
      421 tsgamltgel kkalievlqp liaehqarrk evtdeivkef mtprklsfdf q
//
LOCUS       XP_047287718             471 aa            linear   PRI 05-AUG-2025
DEFINITION  tryptophan--tRNA ligase, cytoplasmic isoform X1 [Homo sapiens].
ACCESSION   XP_047287718
VERSION     XP_047287718.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431762.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..471
                     /product="tryptophan--tRNA ligase, cytoplasmic isoform X1"
                     /calculated_mol_wt=53035
     Region          12..61
                     /region_name="WEPRS_RNA"
                     /note="WEPRS_RNA binding domain. This short RNA-binding
                     domain is found in several higher eukaryote aminoacyl-tRNA
                     synthetases (aaRSs). It is found in multiple copies in
                     eukaryotic bifunctional glutamyl-prolyl-tRNA synthetases
                     (EPRS) in a region that separates...; cd00936"
                     /db_xref="CDD:238473"
     Site            order(19,21,24,29,34,38,46,54)
                     /site_type="other"
                     /note="tRNA binding site [nucleotide binding]"
                     /db_xref="CDD:238473"
     Region          85..466
                     /region_name="PLN02486"
                     /note="aminoacyl-tRNA ligase"
                     /db_xref="CDD:178104"
     Site            order(159..163,170,172..173,176,194,199,237,280,284,287,
                     307,309..310,312..313,316,339,349..350,352)
                     /site_type="active"
                     /db_xref="CDD:173903"
     Site            170..173
                     /site_type="other"
                     /note="HIGH motif"
                     /db_xref="CDD:173903"
     Site            order(198,201..202,247..248,250..252,255..256,258..261,
                     263..264,276,278..279,282..283)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:173903"
     Site            349..353
                     /site_type="other"
                     /note="KMSKS motif"
                     /db_xref="CDD:173903"
     CDS             1..471
                     /gene="WARS1"
                     /gene_synonym="GAMMA-2; HMN9; HMND9; IFI53; IFP53;
                     NEDMSBA; WARS"
                     /coded_by="XM_047431762.1:251..1666"
                     /db_xref="GeneID:7453"
                     /db_xref="HGNC:HGNC:12729"
                     /db_xref="MIM:191050"
ORIGIN      
        1 mpnsepasll elfnsiatqg elvrslkagn askdeidsav kmlvslkmsy kaaagedyka
       61 dcppgnpapt snhgpdatea eedfvdpwtv qtssakgidy dklivrfgss kidkelinri
      121 eratgqrphh flrrgiffsh rdmnqvlday enkkpfylyt grgpsseamh vghlipfift
      181 kwlqdvfnvp lviqmtddek ylwkdltldq aysyavenak diiacgfdin ktfifsdldy
      241 mgmssgfykn vvkiqkhvtf nqvkgifgft dsdcigkisf paiqaapsfs nsfpqifrdr
      301 tdiqclipca idqdpyfrmt rdvaprigyp kpallhstff palqgaqtkm sasdpnssif
      361 ltdtakqikt kvnkhafsgg rdtieehrqf ggncdvdvsf myltffledd dkleqirkdy
      421 tsgamltgel kkalievlqp liaehqarrk evtdeivkef mtprklsfdf q
//
LOCUS       XP_047287719             471 aa            linear   PRI 05-AUG-2025
DEFINITION  tryptophan--tRNA ligase, cytoplasmic isoform X1 [Homo sapiens].
ACCESSION   XP_047287719
VERSION     XP_047287719.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431763.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..471
                     /product="tryptophan--tRNA ligase, cytoplasmic isoform X1"
                     /calculated_mol_wt=53035
     Region          12..61
                     /region_name="WEPRS_RNA"
                     /note="WEPRS_RNA binding domain. This short RNA-binding
                     domain is found in several higher eukaryote aminoacyl-tRNA
                     synthetases (aaRSs). It is found in multiple copies in
                     eukaryotic bifunctional glutamyl-prolyl-tRNA synthetases
                     (EPRS) in a region that separates...; cd00936"
                     /db_xref="CDD:238473"
     Site            order(19,21,24,29,34,38,46,54)
                     /site_type="other"
                     /note="tRNA binding site [nucleotide binding]"
                     /db_xref="CDD:238473"
     Region          85..466
                     /region_name="PLN02486"
                     /note="aminoacyl-tRNA ligase"
                     /db_xref="CDD:178104"
     Site            order(159..163,170,172..173,176,194,199,237,280,284,287,
                     307,309..310,312..313,316,339,349..350,352)
                     /site_type="active"
                     /db_xref="CDD:173903"
     Site            170..173
                     /site_type="other"
                     /note="HIGH motif"
                     /db_xref="CDD:173903"
     Site            order(198,201..202,247..248,250..252,255..256,258..261,
                     263..264,276,278..279,282..283)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:173903"
     Site            349..353
                     /site_type="other"
                     /note="KMSKS motif"
                     /db_xref="CDD:173903"
     CDS             1..471
                     /gene="WARS1"
                     /gene_synonym="GAMMA-2; HMN9; HMND9; IFI53; IFP53;
                     NEDMSBA; WARS"
                     /coded_by="XM_047431763.1:272..1687"
                     /db_xref="GeneID:7453"
                     /db_xref="HGNC:HGNC:12729"
                     /db_xref="MIM:191050"
ORIGIN      
        1 mpnsepasll elfnsiatqg elvrslkagn askdeidsav kmlvslkmsy kaaagedyka
       61 dcppgnpapt snhgpdatea eedfvdpwtv qtssakgidy dklivrfgss kidkelinri
      121 eratgqrphh flrrgiffsh rdmnqvlday enkkpfylyt grgpsseamh vghlipfift
      181 kwlqdvfnvp lviqmtddek ylwkdltldq aysyavenak diiacgfdin ktfifsdldy
      241 mgmssgfykn vvkiqkhvtf nqvkgifgft dsdcigkisf paiqaapsfs nsfpqifrdr
      301 tdiqclipca idqdpyfrmt rdvaprigyp kpallhstff palqgaqtkm sasdpnssif
      361 ltdtakqikt kvnkhafsgg rdtieehrqf ggncdvdvsf myltffledd dkleqirkdy
      421 tsgamltgel kkalievlqp liaehqarrk evtdeivkef mtprklsfdf q
//
LOCUS       XP_047287720             471 aa            linear   PRI 05-AUG-2025
DEFINITION  tryptophan--tRNA ligase, cytoplasmic isoform X1 [Homo sapiens].
ACCESSION   XP_047287720
VERSION     XP_047287720.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431764.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..471
                     /product="tryptophan--tRNA ligase, cytoplasmic isoform X1"
                     /calculated_mol_wt=53035
     Region          12..61
                     /region_name="WEPRS_RNA"
                     /note="WEPRS_RNA binding domain. This short RNA-binding
                     domain is found in several higher eukaryote aminoacyl-tRNA
                     synthetases (aaRSs). It is found in multiple copies in
                     eukaryotic bifunctional glutamyl-prolyl-tRNA synthetases
                     (EPRS) in a region that separates...; cd00936"
                     /db_xref="CDD:238473"
     Site            order(19,21,24,29,34,38,46,54)
                     /site_type="other"
                     /note="tRNA binding site [nucleotide binding]"
                     /db_xref="CDD:238473"
     Region          85..466
                     /region_name="PLN02486"
                     /note="aminoacyl-tRNA ligase"
                     /db_xref="CDD:178104"
     Site            order(159..163,170,172..173,176,194,199,237,280,284,287,
                     307,309..310,312..313,316,339,349..350,352)
                     /site_type="active"
                     /db_xref="CDD:173903"
     Site            170..173
                     /site_type="other"
                     /note="HIGH motif"
                     /db_xref="CDD:173903"
     Site            order(198,201..202,247..248,250..252,255..256,258..261,
                     263..264,276,278..279,282..283)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:173903"
     Site            349..353
                     /site_type="other"
                     /note="KMSKS motif"
                     /db_xref="CDD:173903"
     CDS             1..471
                     /gene="WARS1"
                     /gene_synonym="GAMMA-2; HMN9; HMND9; IFI53; IFP53;
                     NEDMSBA; WARS"
                     /coded_by="XM_047431764.1:254..1669"
                     /db_xref="GeneID:7453"
                     /db_xref="HGNC:HGNC:12729"
                     /db_xref="MIM:191050"
ORIGIN      
        1 mpnsepasll elfnsiatqg elvrslkagn askdeidsav kmlvslkmsy kaaagedyka
       61 dcppgnpapt snhgpdatea eedfvdpwtv qtssakgidy dklivrfgss kidkelinri
      121 eratgqrphh flrrgiffsh rdmnqvlday enkkpfylyt grgpsseamh vghlipfift
      181 kwlqdvfnvp lviqmtddek ylwkdltldq aysyavenak diiacgfdin ktfifsdldy
      241 mgmssgfykn vvkiqkhvtf nqvkgifgft dsdcigkisf paiqaapsfs nsfpqifrdr
      301 tdiqclipca idqdpyfrmt rdvaprigyp kpallhstff palqgaqtkm sasdpnssif
      361 ltdtakqikt kvnkhafsgg rdtieehrqf ggncdvdvsf myltffledd dkleqirkdy
      421 tsgamltgel kkalievlqp liaehqarrk evtdeivkef mtprklsfdf q
//
LOCUS       XP_047287721             458 aa            linear   PRI 05-AUG-2025
DEFINITION  tryptophan--tRNA ligase, cytoplasmic isoform X2 [Homo sapiens].
ACCESSION   XP_047287721
VERSION     XP_047287721.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431765.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..458
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..458
                     /product="tryptophan--tRNA ligase, cytoplasmic isoform X2"
                     /calculated_mol_wt=51862
     Region          <20..51
                     /region_name="WHEP-TRS"
                     /note="WHEP-TRS domain; pfam00458"
                     /db_xref="CDD:459819"
     Region          72..453
                     /region_name="PLN02486"
                     /note="aminoacyl-tRNA ligase"
                     /db_xref="CDD:178104"
     Site            order(146..150,157,159..160,163,181,186,224,267,271,274,
                     294,296..297,299..300,303,326,336..337,339)
                     /site_type="active"
                     /db_xref="CDD:173903"
     Site            157..160
                     /site_type="other"
                     /note="HIGH motif"
                     /db_xref="CDD:173903"
     Site            order(185,188..189,234..235,237..239,242..243,245..248,
                     250..251,263,265..266,269..270)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:173903"
     Site            336..340
                     /site_type="other"
                     /note="KMSKS motif"
                     /db_xref="CDD:173903"
     CDS             1..458
                     /gene="WARS1"
                     /gene_synonym="GAMMA-2; HMN9; HMND9; IFI53; IFP53;
                     NEDMSBA; WARS"
                     /coded_by="XM_047431765.1:121..1497"
                     /db_xref="GeneID:7453"
                     /db_xref="HGNC:HGNC:12729"
                     /db_xref="MIM:191050"
ORIGIN      
        1 megrwrgaqw pgppgtsfrk deidsavkml vslkmsykaa agedykadcp pgnpaptsnh
       61 gpdateaeed fvdpwtvqts sakgidydkl ivrfgsskid kelinriera tgqrphhflr
      121 rgiffshrdm nqvldayenk kpfylytgrg psseamhvgh lipfiftkwl qdvfnvplvi
      181 qmtddekylw kdltldqays yavenakdii acgfdinktf ifsdldymgm ssgfyknvvk
      241 iqkhvtfnqv kgifgftdsd cigkisfpai qaapsfsnsf pqifrdrtdi qclipcaidq
      301 dpyfrmtrdv aprigypkpa llhstffpal qgaqtkmsas dpnssifltd takqiktkvn
      361 khafsggrdt ieehrqfggn cdvdvsfmyl tffledddkl eqirkdytsg amltgelkka
      421 lievlqplia ehqarrkevt deivkefmtp rklsfdfq
//
LOCUS       XP_011535438             430 aa            linear   PRI 05-AUG-2025
DEFINITION  tryptophan--tRNA ligase, cytoplasmic isoform X3 [Homo sapiens].
ACCESSION   XP_011535438
VERSION     XP_011535438.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537136.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..430
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..430
                     /product="tryptophan--tRNA ligase, cytoplasmic isoform X3"
                     /calculated_mol_wt=48721
     Region          <2..23
                     /region_name="WHEP-TRS"
                     /note="WHEP-TRS domain; pfam00458"
                     /db_xref="CDD:459819"
     Region          44..425
                     /region_name="PLN02486"
                     /note="aminoacyl-tRNA ligase"
                     /db_xref="CDD:178104"
     Site            order(118..122,129,131..132,135,153,158,196,239,243,246,
                     266,268..269,271..272,275,298,308..309,311)
                     /site_type="active"
                     /db_xref="CDD:173903"
     Site            129..132
                     /site_type="other"
                     /note="HIGH motif"
                     /db_xref="CDD:173903"
     Site            order(157,160..161,206..207,209..211,214..215,217..220,
                     222..223,235,237..238,241..242)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:173903"
     Site            308..312
                     /site_type="other"
                     /note="KMSKS motif"
                     /db_xref="CDD:173903"
     CDS             1..430
                     /gene="WARS1"
                     /gene_synonym="GAMMA-2; HMN9; HMND9; IFI53; IFP53;
                     NEDMSBA; WARS"
                     /coded_by="XM_011537136.4:199..1491"
                     /db_xref="GeneID:7453"
                     /db_xref="HGNC:HGNC:12729"
                     /db_xref="MIM:191050"
ORIGIN      
        1 mlvslkmsyk aaagedykad cppgnpapts nhgpdateae edfvdpwtvq tssakgidyd
       61 klivrfgssk idkelinrie ratgqrphhf lrrgiffshr dmnqvldaye nkkpfylytg
      121 rgpsseamhv ghlipfiftk wlqdvfnvpl viqmtddeky lwkdltldqa ysyavenakd
      181 iiacgfdink tfifsdldym gmssgfyknv vkiqkhvtfn qvkgifgftd sdcigkisfp
      241 aiqaapsfsn sfpqifrdrt diqclipcai dqdpyfrmtr dvaprigypk pallhstffp
      301 alqgaqtkms asdpnssifl tdtakqiktk vnkhafsggr dtieehrqfg gncdvdvsfm
      361 yltffleddd kleqirkdyt sgamltgelk kalievlqpl iaehqarrke vtdeivkefm
      421 tprklsfdfq
//
LOCUS       XP_005268103             346 aa            linear   PRI 05-AUG-2025
DEFINITION  DNA repair protein XRCC3 isoform X1 [Homo sapiens].
ACCESSION   XP_005268103
VERSION     XP_005268103.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005268046.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..346
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..346
                     /product="DNA repair protein XRCC3 isoform X1"
                     /calculated_mol_wt=37719
     Region          89..325
                     /region_name="XRCC3"
                     /note="XRCC3 recombinase; cd19491"
                     /db_xref="CDD:410899"
     Site            order(110..115,143,213,258,300)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:410899"
     CDS             1..346
                     /gene="XRCC3"
                     /gene_synonym="CMM6"
                     /coded_by="XM_005268046.3:383..1423"
                     /db_xref="GeneID:7517"
                     /db_xref="HGNC:HGNC:12830"
                     /db_xref="MIM:600675"
ORIGIN      
        1 mdldlldlnp riiaaikkak lksvkevlhf sgpdlkrltn lsspevwhll rtaslhlrgs
       61 siltalqlhq qkerfptqhq rlslgcpvld allrgglpld gitelagrss agktqlalql
      121 clavqfprqh ggleagavyi ctedafphkr lqqlmaqqpr lrtdvpgell qklrfgsqif
      181 iehvadvdtl lecvnkkvpv llsrgmarlv vidsvaapfr cefdsqasap rarhlqslga
      241 tlrelssafq spvlcinqvt eameeqgaah gplgfwderv spalgitwan qllvrlladr
      301 lreeeaalgc partlrvlsa phlppsscsy tisaegvrgt pgtqsh
//
LOCUS       XP_047287722             346 aa            linear   PRI 05-AUG-2025
DEFINITION  DNA repair protein XRCC3 isoform X1 [Homo sapiens].
ACCESSION   XP_047287722
VERSION     XP_047287722.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431766.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..346
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..346
                     /product="DNA repair protein XRCC3 isoform X1"
                     /calculated_mol_wt=37719
     Region          89..325
                     /region_name="XRCC3"
                     /note="XRCC3 recombinase; cd19491"
                     /db_xref="CDD:410899"
     Site            order(110..115,143,213,258,300)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:410899"
     CDS             1..346
                     /gene="XRCC3"
                     /gene_synonym="CMM6"
                     /coded_by="XM_047431766.1:443..1483"
                     /db_xref="GeneID:7517"
                     /db_xref="HGNC:HGNC:12830"
                     /db_xref="MIM:600675"
ORIGIN      
        1 mdldlldlnp riiaaikkak lksvkevlhf sgpdlkrltn lsspevwhll rtaslhlrgs
       61 siltalqlhq qkerfptqhq rlslgcpvld allrgglpld gitelagrss agktqlalql
      121 clavqfprqh ggleagavyi ctedafphkr lqqlmaqqpr lrtdvpgell qklrfgsqif
      181 iehvadvdtl lecvnkkvpv llsrgmarlv vidsvaapfr cefdsqasap rarhlqslga
      241 tlrelssafq spvlcinqvt eameeqgaah gplgfwderv spalgitwan qllvrlladr
      301 lreeeaalgc partlrvlsa phlppsscsy tisaegvrgt pgtqsh
//
LOCUS       XP_047287723             346 aa            linear   PRI 05-AUG-2025
DEFINITION  DNA repair protein XRCC3 isoform X1 [Homo sapiens].
ACCESSION   XP_047287723
VERSION     XP_047287723.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431767.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..346
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..346
                     /product="DNA repair protein XRCC3 isoform X1"
                     /calculated_mol_wt=37719
     Region          89..325
                     /region_name="XRCC3"
                     /note="XRCC3 recombinase; cd19491"
                     /db_xref="CDD:410899"
     Site            order(110..115,143,213,258,300)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:410899"
     CDS             1..346
                     /gene="XRCC3"
                     /gene_synonym="CMM6"
                     /coded_by="XM_047431767.1:610..1650"
                     /db_xref="GeneID:7517"
                     /db_xref="HGNC:HGNC:12830"
                     /db_xref="MIM:600675"
ORIGIN      
        1 mdldlldlnp riiaaikkak lksvkevlhf sgpdlkrltn lsspevwhll rtaslhlrgs
       61 siltalqlhq qkerfptqhq rlslgcpvld allrgglpld gitelagrss agktqlalql
      121 clavqfprqh ggleagavyi ctedafphkr lqqlmaqqpr lrtdvpgell qklrfgsqif
      181 iehvadvdtl lecvnkkvpv llsrgmarlv vidsvaapfr cefdsqasap rarhlqslga
      241 tlrelssafq spvlcinqvt eameeqgaah gplgfwderv spalgitwan qllvrlladr
      301 lreeeaalgc partlrvlsa phlppsscsy tisaegvrgt pgtqsh
//
LOCUS       XP_047287724             346 aa            linear   PRI 05-AUG-2025
DEFINITION  DNA repair protein XRCC3 isoform X1 [Homo sapiens].
ACCESSION   XP_047287724
VERSION     XP_047287724.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431768.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..346
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..346
                     /product="DNA repair protein XRCC3 isoform X1"
                     /calculated_mol_wt=37719
     Region          89..325
                     /region_name="XRCC3"
                     /note="XRCC3 recombinase; cd19491"
                     /db_xref="CDD:410899"
     Site            order(110..115,143,213,258,300)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:410899"
     CDS             1..346
                     /gene="XRCC3"
                     /gene_synonym="CMM6"
                     /coded_by="XM_047431768.1:450..1490"
                     /db_xref="GeneID:7517"
                     /db_xref="HGNC:HGNC:12830"
                     /db_xref="MIM:600675"
ORIGIN      
        1 mdldlldlnp riiaaikkak lksvkevlhf sgpdlkrltn lsspevwhll rtaslhlrgs
       61 siltalqlhq qkerfptqhq rlslgcpvld allrgglpld gitelagrss agktqlalql
      121 clavqfprqh ggleagavyi ctedafphkr lqqlmaqqpr lrtdvpgell qklrfgsqif
      181 iehvadvdtl lecvnkkvpv llsrgmarlv vidsvaapfr cefdsqasap rarhlqslga
      241 tlrelssafq spvlcinqvt eameeqgaah gplgfwderv spalgitwan qllvrlladr
      301 lreeeaalgc partlrvlsa phlppsscsy tisaegvrgt pgtqsh
//
LOCUS       XP_047287726             187 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger and BTB domain-containing protein 25 isoform X1 [Homo
            sapiens].
ACCESSION   XP_047287726
VERSION     XP_047287726.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431770.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..187
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..187
                     /product="zinc finger and BTB domain-containing protein 25
                     isoform X1"
                     /calculated_mol_wt=21302
     Region          42..>125
                     /region_name="BTB_POZ"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain superfamily; cl38908"
                     /db_xref="CDD:453885"
     Region          103..123
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275370"
     CDS             1..187
                     /gene="ZBTB25"
                     /gene_synonym="C14orf51; KUP; ZNF46"
                     /coded_by="XM_047431770.1:296..859"
                     /db_xref="GeneID:7597"
                     /db_xref="HGNC:HGNC:13112"
                     /db_xref="MIM:194541"
ORIGIN      
        1 mfqqlapasp qgikfgilsl etqvlaelli lsqdsvittm dtashslvll qqlnmqrefg
       61 flcdctvaig dvyfkahrav laafsnyfkm ifihqtrkrk mscticghkf prksqllehm
      121 ythkgksyry nrcqrfgnal aqrfqpycds wsdvslkssr lsqehldlpc aleseltqen
      181 vdtilve
//
LOCUS       XP_047287728             311 aa            linear   PRI 05-AUG-2025
DEFINITION  WD repeat-containing protein 25 isoform X1 [Homo sapiens].
ACCESSION   XP_047287728
VERSION     XP_047287728.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431772.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..311
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..311
                     /product="WD repeat-containing protein 25 isoform X1"
                     /calculated_mol_wt=34738
     Region          <31..310
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          63..97
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          103..140
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          147..189
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          196..235
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          243..279
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          285..310
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..311
                     /gene="WDR25"
                     /gene_synonym="C14orf67"
                     /coded_by="XM_047431772.1:14459..15394"
                     /db_xref="GeneID:79446"
                     /db_xref="HGNC:HGNC:21064"
                     /db_xref="MIM:618059"
ORIGIN      
        1 myfkqregic kaggsrnrvs lgnaprkwra rtivmgdeag qvwnavdsgh clqtyslhte
       61 avraarwapc grrilsggfd falhltdlet gtqlfsgrsd frittlkfhp kdhniflcgg
      121 fssemkawdi rtgkvmrsyk atiqqtldil flregsefls stdastrdsa drtiiawdfr
      181 tsakisnqif herftcpsla lhprepvfla qtngnylalf stvwpyrmsr rrryeghkve
      241 gysvgcecsp ggdllvtgsa dgrvlmysfr tasractlqg htqacvgtty hpvlpsvlat
      301 cswggdmkiw h
//
LOCUS       XP_011535455             311 aa            linear   PRI 05-AUG-2025
DEFINITION  olfactory receptor 4K1 isoform X1 [Homo sapiens].
ACCESSION   XP_011535455
VERSION     XP_011535455.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537153.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..311
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..311
                     /product="olfactory receptor 4K1 isoform X1"
                     /calculated_mol_wt=35070
     Region          25..291
                     /region_name="7tmA_OR4-like"
                     /note="olfactory receptor family 4 and related proteins,
                     member of the class A family of seven-transmembrane G
                     protein-coupled receptors; cd15226"
                     /db_xref="CDD:320354"
     Region          26..52
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:320354"
     Region          59..85
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320354"
     Site            order(81,84..85,97..102,104..105,108,153,155..159,195,
                     198..200,202..204,206..207,251,254..255,257..258,261,
                     265..266,268..270,273,276..277)
                     /site_type="other"
                     /note="putative ligand binding pocket [chemical binding]"
                     /db_xref="CDD:320354"
     Region          97..127
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320354"
     Region          140..161
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320354"
     Region          195..225
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320354"
     Region          231..261
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320354"
     Region          266..291
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320354"
     CDS             1..311
                     /gene="OR4K1"
                     /gene_synonym="OR14-19"
                     /coded_by="XM_011537153.3:172..1107"
                     /db_xref="GeneID:79544"
                     /db_xref="HGNC:HGNC:14726"
ORIGIN      
        1 mahtnesmvs efvllglsns wglqlfffai fsivyvtsvl gnvliiviis fdshlnspmy
       61 fllsnlsfid icqsnfatpk mlvdffierk tisfegcmaq ifvlhsfvgs emmllvamay
      121 drfiaickpl hystimnrrl cvifvsiswa vgvlhsvshl aftvdlpfcg pnevdsffcd
      181 lplvielacm dtyemeimtl tnsglislsc flaliisyti iligvrcrss sgsskalstl
      241 tahitvvilf fgpciyfyiw pfsrlpvdkf lsvfytvctp llnpiiyslr nedvkaamwk
      301 lrnrhvnswk n
//
LOCUS       XP_005268117             272 aa            linear   PRI 05-AUG-2025
DEFINITION  protein N-lysine methyltransferase METTL21D isoform X1 [Homo
            sapiens].
ACCESSION   XP_005268117
VERSION     XP_005268117.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005268060.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..272
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..272
                     /product="protein N-lysine methyltransferase METTL21D
                     isoform X1"
                     /calculated_mol_wt=30647
     Region          22..195
                     /region_name="Methyltransf_16"
                     /note="Lysine methyltransferase; pfam10294"
                     /db_xref="CDD:313513"
     Site            order(74..80,96..97,124..126,143)
                     /site_type="other"
                     /note="S-adenosylmethionine binding site [chemical
                     binding]"
                     /db_xref="CDD:100107"
     CDS             1..272
                     /gene="VCPKMT"
                     /gene_synonym="C14orf138; METTL21D; VCP-KMT"
                     /coded_by="XM_005268060.5:21..839"
                     /db_xref="GeneID:79609"
                     /db_xref="HGNC:HGNC:20352"
                     /db_xref="MIM:615260"
ORIGIN      
        1 madtlessle dplrsfvrvl ekrdgtvlrl qqyssggvgc vvwdaaivls kyletpefsg
       61 dgahalsrrs vlelgsgtga vglmaatlga dvvvtdleel qdllkmninm nkhlvtgsvq
      121 akvlkwgeei egfpsppdfi lmadciyyee slepllktlk disgfetcii ccyeqrtmgk
      181 npeiekkyfe llqldfdfek iplekhdeey rsedihiiyi rkkksemkyn kadesikdkc
      241 tqlsriyvfs rflvhvlpci titfyagcls dt
//
LOCUS       XP_016877129             242 aa            linear   PRI 05-AUG-2025
DEFINITION  protein N-lysine methyltransferase METTL21D isoform X2 [Homo
            sapiens].
ACCESSION   XP_016877129
VERSION     XP_016877129.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021640.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..242
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..242
                     /product="protein N-lysine methyltransferase METTL21D
                     isoform X2"
                     /calculated_mol_wt=27261
     Region          22..195
                     /region_name="Methyltransf_16"
                     /note="Lysine methyltransferase; pfam10294"
                     /db_xref="CDD:313513"
     Site            order(74..80,96..97,124..126,143)
                     /site_type="other"
                     /note="S-adenosylmethionine binding site [chemical
                     binding]"
                     /db_xref="CDD:100107"
     CDS             1..242
                     /gene="VCPKMT"
                     /gene_synonym="C14orf138; METTL21D; VCP-KMT"
                     /coded_by="XM_017021640.3:21..749"
                     /db_xref="GeneID:79609"
                     /db_xref="HGNC:HGNC:20352"
                     /db_xref="MIM:615260"
ORIGIN      
        1 madtlessle dplrsfvrvl ekrdgtvlrl qqyssggvgc vvwdaaivls kyletpefsg
       61 dgahalsrrs vlelgsgtga vglmaatlga dvvvtdleel qdllkmninm nkhlvtgsvq
      121 akvlkwgeei egfpsppdfi lmadciyyee slepllktlk disgfetcii ccyeqrtmgk
      181 npeiekkyfe llqldfdfek iplekhdeey rsedihiiyi rkkksqqipk hgdrirgvmw
      241 el
//
LOCUS       XP_047287729             190 aa            linear   PRI 05-AUG-2025
DEFINITION  protein N-lysine methyltransferase METTL21D isoform X3 [Homo
            sapiens].
ACCESSION   XP_047287729
VERSION     XP_047287729.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431773.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..190
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..190
                     /product="protein N-lysine methyltransferase METTL21D
                     isoform X3"
                     /calculated_mol_wt=20844
     Region          22..190
                     /region_name="Methyltransf_16"
                     /note="Lysine methyltransferase; pfam10294"
                     /db_xref="CDD:313513"
     Site            order(74..80,96..97,124..126,143)
                     /site_type="other"
                     /note="S-adenosylmethionine binding site [chemical
                     binding]"
                     /db_xref="CDD:100107"
     CDS             1..190
                     /gene="VCPKMT"
                     /gene_synonym="C14orf138; METTL21D; VCP-KMT"
                     /coded_by="XM_047431773.1:21..593"
                     /db_xref="GeneID:79609"
                     /db_xref="HGNC:HGNC:20352"
                     /db_xref="MIM:615260"
ORIGIN      
        1 madtlessle dplrsfvrvl ekrdgtvlrl qqyssggvgc vvwdaaivls kyletpefsg
       61 dgahalsrrs vlelgsgtga vglmaatlga dvvvtdleel qdllkmninm nkhlvtgsvq
      121 akvlkwgeei egfpsppdfi lmadciyyee slepllktlk disgfetcii ccyeqrtmgk
      181 npeiekkyfe
//
LOCUS       XP_011535457             456 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger C2HC domain-containing protein 1C isoform X1 [Homo
            sapiens].
ACCESSION   XP_011535457
VERSION     XP_011535457.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537155.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..456
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..456
                     /product="zinc finger C2HC domain-containing protein 1C
                     isoform X1"
                     /calculated_mol_wt=51527
     Region          387..410
                     /region_name="zf-C2HC_2"
                     /note="zinc-finger of a C2HC-type; pfam13913"
                     /db_xref="CDD:464037"
     CDS             1..456
                     /gene="ZC2HC1C"
                     /gene_synonym="C14orf140; FAM164C"
                     /coded_by="XM_011537155.3:328..1698"
                     /db_xref="GeneID:79696"
                     /db_xref="HGNC:HGNC:20354"
ORIGIN      
        1 maglqrlash lpvgvmlphn tteapgphsa kqdsyeqgds sqqslkghlr nnfqkqllsn
       61 kelildkvyt hpkwntqtka rsysyphctg isqqdpesds qgqgnglfys sgpqswypka
      121 nnqdfipftk krvgvdrafp lkpmvhrksc stgeagtdgd hnvyprppep refssrnfgv
      181 rnqgnfsvvg tvlaatqaek avanfdrtew vqirrleaag esleeeirrk qillrgklkk
      241 teeelrriqt qkeqakenen gelqkiilpr srvkgnksnt mykpifspef efeeefsrdr
      301 redetwgrsq qnsgpfqfsd yriqrlkrer lvasnnkird pvsepsvekf sppsetpvga
      361 lqgsarnssl smapdssgss gsieepqlge cshcgrkfls frlerhsnic srmrgskrkv
      421 fdssrarakg teleqylnwk gpasakaepp qksnwr
//
LOCUS       XP_005268119             456 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger C2HC domain-containing protein 1C isoform X1 [Homo
            sapiens].
ACCESSION   XP_005268119
VERSION     XP_005268119.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005268062.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..456
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..456
                     /product="zinc finger C2HC domain-containing protein 1C
                     isoform X1"
                     /calculated_mol_wt=51527
     Region          387..410
                     /region_name="zf-C2HC_2"
                     /note="zinc-finger of a C2HC-type; pfam13913"
                     /db_xref="CDD:464037"
     CDS             1..456
                     /gene="ZC2HC1C"
                     /gene_synonym="C14orf140; FAM164C"
                     /coded_by="XM_005268062.4:305..1675"
                     /db_xref="GeneID:79696"
                     /db_xref="HGNC:HGNC:20354"
ORIGIN      
        1 maglqrlash lpvgvmlphn tteapgphsa kqdsyeqgds sqqslkghlr nnfqkqllsn
       61 kelildkvyt hpkwntqtka rsysyphctg isqqdpesds qgqgnglfys sgpqswypka
      121 nnqdfipftk krvgvdrafp lkpmvhrksc stgeagtdgd hnvyprppep refssrnfgv
      181 rnqgnfsvvg tvlaatqaek avanfdrtew vqirrleaag esleeeirrk qillrgklkk
      241 teeelrriqt qkeqakenen gelqkiilpr srvkgnksnt mykpifspef efeeefsrdr
      301 redetwgrsq qnsgpfqfsd yriqrlkrer lvasnnkird pvsepsvekf sppsetpvga
      361 lqgsarnssl smapdssgss gsieepqlge cshcgrkfls frlerhsnic srmrgskrkv
      421 fdssrarakg teleqylnwk gpasakaepp qksnwr
//
LOCUS       XP_011535458             456 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger C2HC domain-containing protein 1C isoform X1 [Homo
            sapiens].
ACCESSION   XP_011535458
VERSION     XP_011535458.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537156.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..456
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..456
                     /product="zinc finger C2HC domain-containing protein 1C
                     isoform X1"
                     /calculated_mol_wt=51527
     Region          387..410
                     /region_name="zf-C2HC_2"
                     /note="zinc-finger of a C2HC-type; pfam13913"
                     /db_xref="CDD:464037"
     CDS             1..456
                     /gene="ZC2HC1C"
                     /gene_synonym="C14orf140; FAM164C"
                     /coded_by="XM_011537156.3:65..1435"
                     /db_xref="GeneID:79696"
                     /db_xref="HGNC:HGNC:20354"
ORIGIN      
        1 maglqrlash lpvgvmlphn tteapgphsa kqdsyeqgds sqqslkghlr nnfqkqllsn
       61 kelildkvyt hpkwntqtka rsysyphctg isqqdpesds qgqgnglfys sgpqswypka
      121 nnqdfipftk krvgvdrafp lkpmvhrksc stgeagtdgd hnvyprppep refssrnfgv
      181 rnqgnfsvvg tvlaatqaek avanfdrtew vqirrleaag esleeeirrk qillrgklkk
      241 teeelrriqt qkeqakenen gelqkiilpr srvkgnksnt mykpifspef efeeefsrdr
      301 redetwgrsq qnsgpfqfsd yriqrlkrer lvasnnkird pvsepsvekf sppsetpvga
      361 lqgsarnssl smapdssgss gsieepqlge cshcgrkfls frlerhsnic srmrgskrkv
      421 fdssrarakg teleqylnwk gpasakaepp qksnwr
//
LOCUS       XP_011535460            1033 aa            linear   PRI 05-AUG-2025
DEFINITION  calmin isoform X1 [Homo sapiens].
ACCESSION   XP_011535460
VERSION     XP_011535460.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537158.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1033
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1033
                     /product="calmin isoform X1"
                     /calculated_mol_wt=115235
     Region          29..142
                     /region_name="CH_CLMN_rpt1"
                     /note="first calponin homology (CH) domain found in calmin
                     and similar proteins; cd21191"
                     /db_xref="CDD:409040"
     Site            order(34,38,92,94..95,98..99,101,110..118,123,125..126,
                     128..129,132..133,136)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409040"
     Region          186..291
                     /region_name="CH_CLMN_rpt2"
                     /note="second calponin homology (CH) domain found in
                     calmin and similar proteins; cd21245"
                     /db_xref="CDD:409094"
     Site            order(189,193,242,244..245,248..249,251,260..268,275,
                     277..278,280..281,284..285,288)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409094"
     CDS             1..1033
                     /gene="CLMN"
                     /coded_by="XM_011537158.2:117..3218"
                     /db_xref="GeneID:79789"
                     /db_xref="HGNC:HGNC:19972"
                     /db_xref="MIM:611121"
ORIGIN      
        1 maahewdwfq reeligqisd irvqnlqver envqkrtftr winlhlekcn pplevkdlfv
       61 diqdgkilma llevlsgrnl lheykssshr ifrlnniaka lkfledsnvk lvsidaaeia
      121 dgnpslvlgl iwniilffqi keltgnlsrn spssslspgs ggtdsdssfp ptptaersva
      181 isvkdqrkai kallawvqrk trkygvavqd fagswrsgla flavikaidp slvdmkqale
      241 nstrenleka fsiaqdalhi prllepedim vdtpdeqsim tyvaqflerf peleaedifd
      301 sdkevpiest fvriketpse qeskvfvlte ngertytvnh etshpppskv fvcdkpesmk
      361 efrldgvssh alsdsstefm hqiidqvlqg gpgktsdise pspessilss rkengrsnsl
      421 pikktvhfea dtykdpfcsk nlslcfegsp rvakeslrqd ghvlavevae ekeqkqessk
      481 ipesssdkva gdiflvegtn nnsqssscng alestarhde eshslsppge ntvmadsfqi
      541 kvnlmtveal eegdyfeaip lkaskfnsdl idfastsqaf nkvpsphetk pdedaeafen
      601 haeklgkrsi ksahkkkdsp epqvkmdkhe phqdsgeeae gcpsapeetp vdkkpevhek
      661 akrkstrphy eeegedddlq gvgeelsssp psscvsletl gshseegldf kpspplskvs
      721 viphdlfyfp hyevplaavl eayvedpedl kneemdleep egympdldsr eeeadgsqss
      781 ssssvpgesl psasdqvlyl srggvgttpa sepaplaphe dhqqretken dpmdshqsqe
      841 spnlenianp leenvtkesi sskkkekrkh vdhvesslfv apgsvqssdd leedssdysi
      901 psrtshsdss iylrrhthrs sesdhfsyvq lrnaadlddr rnriltryst qkltelilqf
      961 ygiradmkre skharmsmka nssgeamslg shspqsdslt qlvqqpdmmy filflwllvy
     1021 clllfpqldv srl
//
LOCUS       XP_016877135            1013 aa            linear   PRI 05-AUG-2025
DEFINITION  calmin isoform X2 [Homo sapiens].
ACCESSION   XP_016877135
VERSION     XP_016877135.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021646.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1013
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1013
                     /product="calmin isoform X2"
                     /calculated_mol_wt=112499
     Region          9..122
                     /region_name="CH_CLMN_rpt1"
                     /note="first calponin homology (CH) domain found in calmin
                     and similar proteins; cd21191"
                     /db_xref="CDD:409040"
     Site            order(14,18,72,74..75,78..79,81,90..98,103,105..106,
                     108..109,112..113,116)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409040"
     Region          166..271
                     /region_name="CH_CLMN_rpt2"
                     /note="second calponin homology (CH) domain found in
                     calmin and similar proteins; cd21245"
                     /db_xref="CDD:409094"
     Site            order(169,173,222,224..225,228..229,231,240..248,255,
                     257..258,260..261,264..265,268)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409094"
     CDS             1..1013
                     /gene="CLMN"
                     /coded_by="XM_017021646.2:347..3388"
                     /db_xref="GeneID:79789"
                     /db_xref="HGNC:HGNC:19972"
                     /db_xref="MIM:611121"
ORIGIN      
        1 mvggasgver envqkrtftr winlhlekcn pplevkdlfv diqdgkilma llevlsgrnl
       61 lheykssshr ifrlnniaka lkfledsnvk lvsidaaeia dgnpslvlgl iwniilffqi
      121 keltgnlsrn spssslspgs ggtdsdssfp ptptaersva isvkdqrkai kallawvqrk
      181 trkygvavqd fagswrsgla flavikaidp slvdmkqale nstrenleka fsiaqdalhi
      241 prllepedim vdtpdeqsim tyvaqflerf peleaedifd sdkevpiest fvriketpse
      301 qeskvfvlte ngertytvnh etshpppskv fvcdkpesmk efrldgvssh alsdsstefm
      361 hqiidqvlqg gpgktsdise pspessilss rkengrsnsl pikktvhfea dtykdpfcsk
      421 nlslcfegsp rvakeslrqd ghvlavevae ekeqkqessk ipesssdkva gdiflvegtn
      481 nnsqssscng alestarhde eshslsppge ntvmadsfqi kvnlmtveal eegdyfeaip
      541 lkaskfnsdl idfastsqaf nkvpsphetk pdedaeafen haeklgkrsi ksahkkkdsp
      601 epqvkmdkhe phqdsgeeae gcpsapeetp vdkkpevhek akrkstrphy eeegedddlq
      661 gvgeelsssp psscvsletl gshseegldf kpspplskvs viphdlfyfp hyevplaavl
      721 eayvedpedl kneemdleep egympdldsr eeeadgsqss ssssvpgesl psasdqvlyl
      781 srggvgttpa sepaplaphe dhqqretken dpmdshqsqe spnlenianp leenvtkesi
      841 sskkkekrkh vdhvesslfv apgsvqssdd leedssdysi psrtshsdss iylrrhthrs
      901 sesdhfsyvq lrnaadlddr rnriltryst qkltelilqf ygiradmkre skharmsmka
      961 nssgeamslg shspqsdslt qlvqqpdmmy filflwllvy clllfpqldv srl
//
LOCUS       XP_011535461             928 aa            linear   PRI 05-AUG-2025
DEFINITION  calmin isoform X3 [Homo sapiens].
ACCESSION   XP_011535461
VERSION     XP_011535461.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537159.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..928
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..928
                     /product="calmin isoform X3"
                     /calculated_mol_wt=103094
     Region          29..142
                     /region_name="CH_CLMN_rpt1"
                     /note="first calponin homology (CH) domain found in calmin
                     and similar proteins; cd21191"
                     /db_xref="CDD:409040"
     Site            order(34,38,92,94..95,98..99,101,110..118,123,125..126,
                     128..129,132..133,136)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409040"
     Region          186..291
                     /region_name="CH_CLMN_rpt2"
                     /note="second calponin homology (CH) domain found in
                     calmin and similar proteins; cd21245"
                     /db_xref="CDD:409094"
     Site            order(189,193,242,244..245,248..249,251,260..268,275,
                     277..278,280..281,284..285,288)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409094"
     CDS             1..928
                     /gene="CLMN"
                     /coded_by="XM_011537159.3:117..2903"
                     /db_xref="GeneID:79789"
                     /db_xref="HGNC:HGNC:19972"
                     /db_xref="MIM:611121"
ORIGIN      
        1 maahewdwfq reeligqisd irvqnlqver envqkrtftr winlhlekcn pplevkdlfv
       61 diqdgkilma llevlsgrnl lheykssshr ifrlnniaka lkfledsnvk lvsidaaeia
      121 dgnpslvlgl iwniilffqi keltgnlsrn spssslspgs ggtdsdssfp ptptaersva
      181 isvkdqrkai kallawvqrk trkygvavqd fagswrsgla flavikaidp slvdmkqale
      241 nstrenleka fsiaqdalhi prllepedim vdtpdeqsim tyvaqflerf peleaedifd
      301 sdkevpiest fvriketpse qeskvfvlte ngertytvnh etshpppskv fvcdkpesmk
      361 efrldgvssh alsdsstefm hqiidqvlqg gpgktsdise pspessilss rkengrsnsl
      421 pikktvhfea dtykdpfcsk nlslcfegsp rvakeslrqd ghvlavevae ekeqkqessk
      481 ipesssdkva gdiflvegtn nnsqssscng alestarhde eshslsppge ntvmadsfqi
      541 kvnlmtveal eegdyfeaip lkaskfnsdl idfastsqaf nkvpsphetk pdedaeafen
      601 haeklgkrsi ksahkkkdsp epqvkmdkhe phqdsgeeae gcpsapeetp vdkkpevhek
      661 akrkstrphy eeegedddlq gvgeelsssp psscvsletl gshseegldf kpspplskvs
      721 viphdlfyfp hyevplaavl eayvedpedl kneemdleep egympdldsr eeeadgsqss
      781 ssssvpgesl psasdqvlyl srggvgttpa sepaplaphe dhqqretken dpmdshqsqe
      841 spnlenianp leenvtkesi sskkkekrkh vdhvesslfv apgsvqssdd leedssdysi
      901 psrtshsdss iylrrhthrs sesrfhly
//
LOCUS       XP_047287730             906 aa            linear   PRI 05-AUG-2025
DEFINITION  calmin isoform X4 [Homo sapiens].
ACCESSION   XP_047287730
VERSION     XP_047287730.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431774.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..906
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..906
                     /product="calmin isoform X4"
                     /calculated_mol_wt=100322
     Region          29..142
                     /region_name="CH_CLMN_rpt1"
                     /note="first calponin homology (CH) domain found in calmin
                     and similar proteins; cd21191"
                     /db_xref="CDD:409040"
     Site            order(34,38,92,94..95,98..99,101,110..118,123,125..126,
                     128..129,132..133,136)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409040"
     Region          186..291
                     /region_name="CH_CLMN_rpt2"
                     /note="second calponin homology (CH) domain found in
                     calmin and similar proteins; cd21245"
                     /db_xref="CDD:409094"
     Site            order(189,193,242,244..245,248..249,251,260..268,275,
                     277..278,280..281,284..285,288)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409094"
     CDS             1..906
                     /gene="CLMN"
                     /coded_by="XM_047431774.1:117..2837"
                     /db_xref="GeneID:79789"
                     /db_xref="HGNC:HGNC:19972"
                     /db_xref="MIM:611121"
ORIGIN      
        1 maahewdwfq reeligqisd irvqnlqver envqkrtftr winlhlekcn pplevkdlfv
       61 diqdgkilma llevlsgrnl lheykssshr ifrlnniaka lkfledsnvk lvsidaaeia
      121 dgnpslvlgl iwniilffqi keltgnlsrn spssslspgs ggtdsdssfp ptptaersva
      181 isvkdqrkai kallawvqrk trkygvavqd fagswrsgla flavikaidp slvdmkqale
      241 nstrenleka fsiaqdalhi prllepedim vdtpdeqsim tyvaqflerf peleaedifd
      301 sdkevpiest fvriketpse qeskvfvlte ngertytvnh etshpppskv fvcdkpesmk
      361 efrldgvssh alsdsstefm hqiidqvlqg gpgktsdise pspessilss rkengrsnsl
      421 pikktvhfea dtykdpfcsk nlslcfegsp rvakeslrqd ghvlavevae ekeqkqessk
      481 ipesssdkva gdiflvegtn nnsqssscng alestarhde eshslsppge ntvmadsfqi
      541 kvnlmtveal eegdyfeaip lkaskfnsdl idfastsqaf nkvpsphetk pdedaeafen
      601 haeklgkrsi ksahkkkdsp epqvkmdkhe phqdsgeeae gcpsapeetp vdkkpevhek
      661 akrkstrphy eeegedddlq gvgeelsssp psscvsletl gshseegldf kpspplskvs
      721 viphdlfyfp hyevplaavl eayvedpedl kneemdleep egympdldsr eeeadgsqss
      781 ssssvpgesl psasdqvlyl srggvgttpa sepaplaphe dhqqretken dpmdshqsqe
      841 spnlenianp leenvtkesi sskkkekrkh vdhvesslfv apgsvqssdd leedssdysi
      901 psspel
//
LOCUS       XP_011535464             475 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger CCCH domain-containing protein 14 isoform X1 [Homo
            sapiens].
ACCESSION   XP_011535464
VERSION     XP_011535464.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537162.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..475
                     /product="zinc finger CCCH domain-containing protein 14
                     isoform X1"
                     /calculated_mol_wt=53647
     CDS             1..475
                     /gene="ZC3H14"
                     /gene_synonym="MRT56; MSUT-2; NY-REN-37; SUT2; UKp68"
                     /coded_by="XM_011537162.4:98..1525"
                     /db_xref="GeneID:79882"
                     /db_xref="HGNC:HGNC:20509"
                     /db_xref="MIM:613279"
ORIGIN      
        1 meigteisrk irsaikgklq elgayvdeel pdyimvmvan kksqdqmted lslflgnnti
       61 rftvwlhgvl dklrsvttep sslkssdtni fdsnvpsnks nfsrgderrh eaavpplaip
      121 sarpekrdsr vstssqeskt tnvrqtyddg aatrlmstvk plrepapsed vidikpepdd
      181 lidedlnfvq enplsqkkpt vtltygssrp sieiyrppas rnadsgvhln rlqfqqqqns
      241 ihaakqldmq sswvyetgrl cepevlnsle etyspffrnn sekmsmeden frkrklpvvs
      301 svvkvkkfnh dgeeeeeddd ygsrtgsiss svsvpakper rpslppskqa nknlilkais
      361 eaqesvtktt nystvpqkqt lpvaprtrts qeellaevvq gqsrtprisp pikeeetkgd
      421 sveknqgdls flsgcfqdll fvfdvlqfhy dvsrrgfpfi fpvwynvwkh piylk
//
LOCUS       XP_016877144             426 aa            linear   PRI 05-AUG-2025
DEFINITION  L-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X2 [Homo
            sapiens].
ACCESSION   XP_016877144
VERSION     XP_016877144.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021655.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..426
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..426
                     /product="L-2-hydroxyglutarate dehydrogenase,
                     mitochondrial isoform X2"
                     /calculated_mol_wt=46758
     Region          24..420
                     /region_name="DAO"
                     /note="FAD dependent oxidoreductase; cl40741"
                     /db_xref="CDD:477422"
     CDS             1..426
                     /gene="L2HGDH"
                     /gene_synonym="C14orf160; L2HGA"
                     /coded_by="XM_017021655.3:637..1917"
                     /db_xref="GeneID:79944"
                     /db_xref="HGNC:HGNC:20499"
                     /db_xref="MIM:609584"
ORIGIN      
        1 mtqkdyitas sfdivivggg ivglasaral ilrhpslsig vlekekdlav hqtghnsgvi
       61 hsgiyykpes lkaklcvqga allyeycqqk gisykqcgkl ivaveqeeip rlqalyekgl
      121 qngvpglrli qqedikkkep ycrglmaidc phtgivdyrq valsfaqdfq eaggsvltnf
      181 evkgiemake spsrsidgmq ypivikntkg eeircqyvvt caglysdris elsgctpdpr
      241 ivpfrgdyll lkpekcylvk gniypvpdsr fpflgvhftp rmdgsiwlgp navlafkreg
      301 yrpfdfsatd vmdiiinsgl iklasqnfsy gvtemykacf lgatvkylqk fipeitisdi
      361 lrgpagvraq aldrdgnlve dfvfdagvgd ignrilhvrn apspaatssi aisgmiadev
      421 qqrfel
//
LOCUS       XP_011535469             418 aa            linear   PRI 05-AUG-2025
DEFINITION  L-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X3 [Homo
            sapiens].
ACCESSION   XP_011535469
VERSION     XP_011535469.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537167.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..418
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..418
                     /product="L-2-hydroxyglutarate dehydrogenase,
                     mitochondrial isoform X3"
                     /calculated_mol_wt=45913
     Region          16..412
                     /region_name="DAO"
                     /note="FAD dependent oxidoreductase; cl40741"
                     /db_xref="CDD:477422"
     CDS             1..418
                     /gene="L2HGDH"
                     /gene_synonym="C14orf160; L2HGA"
                     /coded_by="XM_011537167.4:601..1857"
                     /db_xref="GeneID:79944"
                     /db_xref="HGNC:HGNC:20499"
                     /db_xref="MIM:609584"
ORIGIN      
        1 mysfdivivg ggivglasar alilrhpsls igvlekekdl avhqtghnsg vihsgiyykp
       61 eslkaklcvq gaallyeycq qkgisykqcg klivaveqee iprlqalyek glqngvpglr
      121 liqqedikkk epycrglmai dcphtgivdy rqvalsfaqd fqeaggsvlt nfevkgiema
      181 kespsrsidg mqypiviknt kgeeircqyv vtcaglysdr iselsgctpd privpfrgdy
      241 lllkpekcyl vkgniypvpd srfpflgvhf tprmdgsiwl gpnavlafkr egyrpfdfsa
      301 tdvmdiiins gliklasqnf sygvtemyka cflgatvkyl qkfipeitis dilrgpagvr
      361 aqaldrdgnl vedfvfdagv gdignrilhv rnapspaats siaisgmiad evqqrfel
//
LOCUS       XP_011535470             281 aa            linear   PRI 05-AUG-2025
DEFINITION  L-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X4 [Homo
            sapiens].
ACCESSION   XP_011535470
VERSION     XP_011535470.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537168.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..281
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..281
                     /product="L-2-hydroxyglutarate dehydrogenase,
                     mitochondrial isoform X4"
                     /calculated_mol_wt=30852
     Region          <2..275
                     /region_name="DAO"
                     /note="FAD dependent oxidoreductase; cl40741"
                     /db_xref="CDD:477422"
     CDS             1..281
                     /gene="L2HGDH"
                     /gene_synonym="C14orf160; L2HGA"
                     /coded_by="XM_011537168.4:97..942"
                     /db_xref="GeneID:79944"
                     /db_xref="HGNC:HGNC:20499"
                     /db_xref="MIM:609584"
ORIGIN      
        1 maidcphtgi vdyrqvalsf aqdfqeaggs vltnfevkgi emakespsrs idgmqypivi
       61 kntkgeeirc qyvvtcagly sdriselsgc tpdprivpfr gdylllkpek cylvkgniyp
      121 vpdsrfpflg vhftprmdgs iwlgpnavla fkregyrpfd fsatdvmdii insgliklas
      181 qnfsygvtem ykacflgatv kylqkfipei tisdilrgpa gvraqaldrd gnlvedfvfd
      241 agvgdignri lhvrnapspa atssiaisgm iadevqqrfe l
//
LOCUS       XP_011535472             601 aa            linear   PRI 05-AUG-2025
DEFINITION  basal body-orientation factor 1 isoform X1 [Homo sapiens].
ACCESSION   XP_011535472
VERSION     XP_011535472.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537170.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..601
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..601
                     /product="basal body-orientation factor 1 isoform X1"
                     /calculated_mol_wt=69684
     Region          77..264
                     /region_name="DUF4515"
                     /note="Domain of unknown function (DUF4515); pfam14988"
                     /db_xref="CDD:405647"
     CDS             1..601
                     /gene="BBOF1"
                     /gene_synonym="C14orf45; CCDC176; FBB10"
                     /coded_by="XM_011537170.3:131..1936"
                     /db_xref="GeneID:80127"
                     /db_xref="HGNC:HGNC:19855"
                     /db_xref="MIM:620496"
ORIGIN      
        1 mpskgkdkkk gkskgkdtkk liktdesvvd rakanaslwe arlevtelsr ikyrdtsril
       61 aksnedlkkk qckmekdims vlsylkkqdq ekdnmieklk qqlnetkeka qeekdkleqk
      121 ytrqineleg qfhqkakeig mihtelkavr qfqkrkiqve relddlkenl rnterihqet
      181 lrrlesrffe ekhrleqeae kkiimlaera hheaivqlnd agrnvfkend ylqkalayhl
      241 ketdalqkns qklqeshtll lhqkswslsh lgihlavsns pdisgittqg filspkggle
      301 eindllvkek imqlvqqrsq iqtlqkkvvn letalsymtk efesevlklq qhamienqag
      361 qveidklqhl lqmkdremnr vkklaknild erteverffl dalhqvkqqi lisrkhykqi
      421 aqaafnlkmr aactgrteyp kirtfdgreh stnsvnqdll eaekwthieg nvdigdltwe
      481 qkekvlrllf akmngcpsrk ynqssrppvp dyvvsdsget kefgdesklq dkifitqqia
      541 isdssgevvl ptipkepqes dtvrslylik qcillspfpm sllaksrlfs llverlqgsv
      601 e
//
LOCUS       XP_011535473             597 aa            linear   PRI 05-AUG-2025
DEFINITION  basal body-orientation factor 1 isoform X2 [Homo sapiens].
ACCESSION   XP_011535473
VERSION     XP_011535473.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537171.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..597
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..597
                     /product="basal body-orientation factor 1 isoform X2"
                     /calculated_mol_wt=69173
     Region          77..264
                     /region_name="DUF4515"
                     /note="Domain of unknown function (DUF4515); pfam14988"
                     /db_xref="CDD:405647"
     CDS             1..597
                     /gene="BBOF1"
                     /gene_synonym="C14orf45; CCDC176; FBB10"
                     /coded_by="XM_011537171.3:131..1924"
                     /db_xref="GeneID:80127"
                     /db_xref="HGNC:HGNC:19855"
                     /db_xref="MIM:620496"
ORIGIN      
        1 mpskgkdkkk gkskgkdtkk liktdesvvd rakanaslwe arlevtelsr ikyrdtsril
       61 aksnedlkkk qckmekdims vlsylkkqdq ekdnmieklk qqlnetkeka qeekdkleqk
      121 ytrqineleg qfhqkakeig mihtelkavr qfqkrkiqve relddlkenl rnterihqet
      181 lrrlesrffe ekhrleqeae kkiimlaera hheaivqlnd agrnvfkend ylqkalayhl
      241 ketdalqkns qklqeshtll lhqkswslsh lgihlavsns pdisgittqg filspkggle
      301 eindllvkek imqlvqqrsq iqtlqkkvvn letalsymtk efesevlklq qhamienqag
      361 qveidklqhl lqmkdremnr vkklaknild erteverffl dalhqvkqqi lisrkhykqi
      421 aqaafnlkmr aactgrteyp kirtfdgreh stnsvnqdll eaekwthieg nvdigdltwe
      481 qkekvlrllf akmngcpsrk ynqssrppvp dyvvsdsget kefgdesklq dkifitqqia
      541 isdssgevvl ptipkepqes dtvrrnllrs tdydltdaag spflaeslll nifkkis
//
LOCUS       XP_005268149             565 aa            linear   PRI 05-AUG-2025
DEFINITION  basal body-orientation factor 1 isoform X3 [Homo sapiens].
ACCESSION   XP_005268149
VERSION     XP_005268149.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005268092.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..565
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..565
                     /product="basal body-orientation factor 1 isoform X3"
                     /calculated_mol_wt=65982
     Region          77..270
                     /region_name="DUF4515"
                     /note="Domain of unknown function (DUF4515); pfam14988"
                     /db_xref="CDD:405647"
     CDS             1..565
                     /gene="BBOF1"
                     /gene_synonym="C14orf45; CCDC176; FBB10"
                     /coded_by="XM_005268092.4:131..1828"
                     /db_xref="GeneID:80127"
                     /db_xref="HGNC:HGNC:19855"
                     /db_xref="MIM:620496"
ORIGIN      
        1 mpskgkdkkk gkskgkdtkk liktdesvvd rakanaslwe arlevtelsr ikyrdtsril
       61 aksnedlkkk qckmekdims vlsylkkqdq ekdnmieklk qqlnetkeka qeekdkleqk
      121 ytrqineleg qfhqkakeig mihtelkavr qfqkrkiqve relddlkenl rnterihqet
      181 lrrlesrffe ekhrleqeae kkiimlaera hheaivqlnd agrnvfkend ylqkalayhl
      241 ketdalqkns qklqeshtll lhqkeindll vkekimqlvq qrsqiqtlqk kvvnletals
      301 ymtkefesev lklqqhamie nqagqveidk lqhllqmkdr emnrvkklak nilderteve
      361 rffldalhqv kqqilisrkh ykqiaqaafn lkmraactgr teypkirtfd grehstnsvn
      421 qdlleaekwt hiegnvdigd ltweqkekvl rllfakmngc psrkynqssr ppvpdyvvsd
      481 sgetkefgde sklqdkifit qqiaisdssg evvlptipke pqesdtvrsl ylikqcills
      541 pfpmsllaks rlfsllverl qgsve
//
LOCUS       XP_011535476             565 aa            linear   PRI 05-AUG-2025
DEFINITION  basal body-orientation factor 1 isoform X4 [Homo sapiens].
ACCESSION   XP_011535476
VERSION     XP_011535476.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537174.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..565
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..565
                     /product="basal body-orientation factor 1 isoform X4"
                     /calculated_mol_wt=65558
     Region          77..264
                     /region_name="DUF4515"
                     /note="Domain of unknown function (DUF4515); pfam14988"
                     /db_xref="CDD:405647"
     CDS             1..565
                     /gene="BBOF1"
                     /gene_synonym="C14orf45; CCDC176; FBB10"
                     /coded_by="XM_011537174.3:131..1828"
                     /db_xref="GeneID:80127"
                     /db_xref="HGNC:HGNC:19855"
                     /db_xref="MIM:620496"
ORIGIN      
        1 mpskgkdkkk gkskgkdtkk liktdesvvd rakanaslwe arlevtelsr ikyrdtsril
       61 aksnedlkkk qckmekdims vlsylkkqdq ekdnmieklk qqlnetkeka qeekdkleqk
      121 ytrqineleg qfhqkakeig mihtelkavr qfqkrkiqve relddlkenl rnterihqet
      181 lrrlesrffe ekhrleqeae kkiimlaera hheaivqlnd agrnvfkend ylqkalayhl
      241 ketdalqkns qklqeshtll lhqkswslsh lgihlavsns pdisgittqg filspkggle
      301 eindllvkek imqlvqqrsq iqtlqkkvvn letalsymtk efesevlklq qhamienqag
      361 qveidklqhl lqmkdremnr vkklaknild erteverffl dalhqvkqqi lisrkhykqi
      421 aqaafnlkmr aactgrteyp kirtfdgreh stnsvnqdll eaekwthieg nvdigdltwe
      481 qkekvlrllf akmngcpsrk ynqssrppvp dyvvsdsget kefgdesklq dkifitqqia
      541 isdssgevvl ptipkepqes dtgtf
//
LOCUS       XP_047287734             561 aa            linear   PRI 05-AUG-2025
DEFINITION  basal body-orientation factor 1 isoform X5 [Homo sapiens].
ACCESSION   XP_047287734
VERSION     XP_047287734.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431778.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..561
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..561
                     /product="basal body-orientation factor 1 isoform X5"
                     /calculated_mol_wt=65471
     Region          77..270
                     /region_name="DUF4515"
                     /note="Domain of unknown function (DUF4515); pfam14988"
                     /db_xref="CDD:405647"
     CDS             1..561
                     /gene="BBOF1"
                     /gene_synonym="C14orf45; CCDC176; FBB10"
                     /coded_by="XM_047431778.1:131..1816"
                     /db_xref="GeneID:80127"
                     /db_xref="HGNC:HGNC:19855"
                     /db_xref="MIM:620496"
ORIGIN      
        1 mpskgkdkkk gkskgkdtkk liktdesvvd rakanaslwe arlevtelsr ikyrdtsril
       61 aksnedlkkk qckmekdims vlsylkkqdq ekdnmieklk qqlnetkeka qeekdkleqk
      121 ytrqineleg qfhqkakeig mihtelkavr qfqkrkiqve relddlkenl rnterihqet
      181 lrrlesrffe ekhrleqeae kkiimlaera hheaivqlnd agrnvfkend ylqkalayhl
      241 ketdalqkns qklqeshtll lhqkeindll vkekimqlvq qrsqiqtlqk kvvnletals
      301 ymtkefesev lklqqhamie nqagqveidk lqhllqmkdr emnrvkklak nilderteve
      361 rffldalhqv kqqilisrkh ykqiaqaafn lkmraactgr teypkirtfd grehstnsvn
      421 qdlleaekwt hiegnvdigd ltweqkekvl rllfakmngc psrkynqssr ppvpdyvvsd
      481 sgetkefgde sklqdkifit qqiaisdssg evvlptipke pqesdtvrrn llrstdydlt
      541 daagspflae slllnifkki s
//
LOCUS       XP_011535477             553 aa            linear   PRI 05-AUG-2025
DEFINITION  basal body-orientation factor 1 isoform X6 [Homo sapiens].
ACCESSION   XP_011535477
VERSION     XP_011535477.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537175.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..553
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..553
                     /product="basal body-orientation factor 1 isoform X6"
                     /calculated_mol_wt=63834
     Region          <29..>327
                     /region_name="CCDC158"
                     /note="Coiled-coil domain-containing protein 158;
                     pfam15921"
                     /db_xref="CDD:464943"
     Region          77..216
                     /region_name="DUF4515"
                     /note="Domain of unknown function (DUF4515); pfam14988"
                     /db_xref="CDD:405647"
     CDS             1..553
                     /gene="BBOF1"
                     /gene_synonym="C14orf45; CCDC176; FBB10"
                     /coded_by="XM_011537175.3:131..1792"
                     /db_xref="GeneID:80127"
                     /db_xref="HGNC:HGNC:19855"
                     /db_xref="MIM:620496"
ORIGIN      
        1 mpskgkdkkk gkskgkdtkk liktdesvvd rakanaslwe arlevtelsr ikyrdtsril
       61 aksnedlkkk qckmekdims vlsylkkqdq ekdnmieklk qqlnetkeka qeekdkllke
      121 nlrnterihq etlrrlesrf feekhrleqe aekkiimlae rahheaivql ndagrnvfke
      181 ndylqkalay hlketdalqk nsqklqesht lllhqkswsl shlgihlavs nspdisgitt
      241 qgfilspkgg leeindllvk ekimqlvqqr sqiqtlqkkv vnletalsym tkefesevlk
      301 lqqhamienq agqveidklq hllqmkdrem nrvkklakni lderteverf fldalhqvkq
      361 qilisrkhyk qiaqaafnlk mraactgrte ypkirtfdgr ehstnsvnqd lleaekwthi
      421 egnvdigdlt weqkekvlrl lfakmngcps rkynqssrpp vpdyvvsdsg etkefgdesk
      481 lqdkifitqq iaisdssgev vlptipkepq esdtvrslyl ikqcillspf pmsllaksrl
      541 fsllverlqg sve
//
LOCUS       XP_011535478             528 aa            linear   PRI 05-AUG-2025
DEFINITION  basal body-orientation factor 1 isoform X7 [Homo sapiens].
ACCESSION   XP_011535478
VERSION     XP_011535478.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537176.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..528
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..528
                     /product="basal body-orientation factor 1 isoform X7"
                     /calculated_mol_wt=61367
     Region          4..191
                     /region_name="DUF4515"
                     /note="Domain of unknown function (DUF4515); pfam14988"
                     /db_xref="CDD:405647"
     CDS             1..528
                     /gene="BBOF1"
                     /gene_synonym="C14orf45; CCDC176; FBB10"
                     /coded_by="XM_011537176.3:401..1987"
                     /db_xref="GeneID:80127"
                     /db_xref="HGNC:HGNC:19855"
                     /db_xref="MIM:620496"
ORIGIN      
        1 mekdimsvls ylkkqdqekd nmieklkqql netkekaqee kdkleqkytr qinelegqfh
       61 qkakeigmih telkavrqfq krkiqverel ddlkenlrnt erihqetlrr lesrffeekh
      121 rleqeaekki imlaerahhe aivqlndagr nvfkendylq kalayhlket dalqknsqkl
      181 qeshtlllhq kswslshlgi hlavsnspdi sgittqgfil spkggleein dllvkekimq
      241 lvqqrsqiqt lqkkvvnlet alsymtkefe sevlklqqha mienqagqve idklqhllqm
      301 kdremnrvkk laknildert everffldal hqvkqqilis rkhykqiaqa afnlkmraac
      361 tgrteypkir tfdgrehstn svnqdlleae kwthiegnvd igdltweqke kvlrllfakm
      421 ngcpsrkynq ssrppvpdyv vsdsgetkef gdesklqdki fitqqiaisd ssgevvlpti
      481 pkepqesdtv rslylikqci llspfpmsll aksrlfsllv erlqgsve
//
LOCUS       XP_047287735             481 aa            linear   PRI 05-AUG-2025
DEFINITION  basal body-orientation factor 1 isoform X8 [Homo sapiens].
ACCESSION   XP_047287735
VERSION     XP_047287735.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431779.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..481
                     /product="basal body-orientation factor 1 isoform X8"
                     /calculated_mol_wt=56005
     Region          77..222
                     /region_name="DUF4515"
                     /note="Domain of unknown function (DUF4515); pfam14988"
                     /db_xref="CDD:405647"
     CDS             1..481
                     /gene="BBOF1"
                     /gene_synonym="C14orf45; CCDC176; FBB10"
                     /coded_by="XM_047431779.1:131..1576"
                     /db_xref="GeneID:80127"
                     /db_xref="HGNC:HGNC:19855"
                     /db_xref="MIM:620496"
ORIGIN      
        1 mpskgkdkkk gkskgkdtkk liktdesvvd rakanaslwe arlevtelsr ikyrdtsril
       61 aksnedlkkk qckmekdims vlsylkkqdq ekdnmieklk qqlnetkeka qeekdkllke
      121 nlrnterihq etlrrlesrf feekhrleqe aekkiimlae rahheaivql ndagrnvfke
      181 ndylqkalay hlketdalqk nsqklqesht lllhqkeind llvkekimql vqqrsqiqtl
      241 qkkvvnleta lsymtkefes evlklqqham ienqagqvei dklqhllqmk dremnrvkkl
      301 aknilderte verffldalh qvkqqilisr khykqiaqaa fnlkmraact grteypkirt
      361 fdgrehstns vnqdlleaek wthiegnvdi gdltweqkek vlrllfakmn gcpsrkynqs
      421 srppvpdyvv sdsgetkefg desklqdkif itqqiaisds sgevvlptip kepqesdtgt
      481 f
//
LOCUS       XP_011535479             461 aa            linear   PRI 05-AUG-2025
DEFINITION  basal body-orientation factor 1 isoform X9 [Homo sapiens].
ACCESSION   XP_011535479
VERSION     XP_011535479.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537177.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..461
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..461
                     /product="basal body-orientation factor 1 isoform X9"
                     /calculated_mol_wt=53300
     Region          <1..124
                     /region_name="DUF4515"
                     /note="Domain of unknown function (DUF4515); pfam14988"
                     /db_xref="CDD:405647"
     CDS             1..461
                     /gene="BBOF1"
                     /gene_synonym="C14orf45; CCDC176; FBB10"
                     /coded_by="XM_011537177.3:322..1707"
                     /db_xref="GeneID:80127"
                     /db_xref="HGNC:HGNC:19855"
                     /db_xref="MIM:620496"
ORIGIN      
        1 mihtelkavr qfqkrkiqve relddlkenl rnterihqet lrrlesrffe ekhrleqeae
       61 kkiimlaera hheaivqlnd agrnvfkend ylqkalayhl ketdalqkns qklqeshtll
      121 lhqkswslsh lgihlavsns pdisgittqg filspkggle eindllvkek imqlvqqrsq
      181 iqtlqkkvvn letalsymtk efesevlklq qhamienqag qveidklqhl lqmkdremnr
      241 vkklaknild erteverffl dalhqvkqqi lisrkhykqi aqaafnlkmr aactgrteyp
      301 kirtfdgreh stnsvnqdll eaekwthieg nvdigdltwe qkekvlrllf akmngcpsrk
      361 ynqssrppvp dyvvsdsget kefgdesklq dkifitqqia isdssgevvl ptipkepqes
      421 dtvrslylik qcillspfpm sllaksrlfs llverlqgsv e
//
LOCUS       XP_011535480             461 aa            linear   PRI 05-AUG-2025
DEFINITION  basal body-orientation factor 1 isoform X9 [Homo sapiens].
ACCESSION   XP_011535480
VERSION     XP_011535480.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537178.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..461
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..461
                     /product="basal body-orientation factor 1 isoform X9"
                     /calculated_mol_wt=53300
     Region          <1..124
                     /region_name="DUF4515"
                     /note="Domain of unknown function (DUF4515); pfam14988"
                     /db_xref="CDD:405647"
     CDS             1..461
                     /gene="BBOF1"
                     /gene_synonym="C14orf45; CCDC176; FBB10"
                     /coded_by="XM_011537178.3:225..1610"
                     /db_xref="GeneID:80127"
                     /db_xref="HGNC:HGNC:19855"
                     /db_xref="MIM:620496"
ORIGIN      
        1 mihtelkavr qfqkrkiqve relddlkenl rnterihqet lrrlesrffe ekhrleqeae
       61 kkiimlaera hheaivqlnd agrnvfkend ylqkalayhl ketdalqkns qklqeshtll
      121 lhqkswslsh lgihlavsns pdisgittqg filspkggle eindllvkek imqlvqqrsq
      181 iqtlqkkvvn letalsymtk efesevlklq qhamienqag qveidklqhl lqmkdremnr
      241 vkklaknild erteverffl dalhqvkqqi lisrkhykqi aqaafnlkmr aactgrteyp
      301 kirtfdgreh stnsvnqdll eaekwthieg nvdigdltwe qkekvlrllf akmngcpsrk
      361 ynqssrppvp dyvvsdsget kefgdesklq dkifitqqia isdssgevvl ptipkepqes
      421 dtvrslylik qcillspfpm sllaksrlfs llverlqgsv e
//
LOCUS       XP_047287736             425 aa            linear   PRI 05-AUG-2025
DEFINITION  basal body-orientation factor 1 isoform X10 [Homo sapiens].
ACCESSION   XP_047287736
VERSION     XP_047287736.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431780.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..425
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..425
                     /product="basal body-orientation factor 1 isoform X10"
                     /calculated_mol_wt=49598
     Region          <1..130
                     /region_name="DUF4515"
                     /note="Domain of unknown function (DUF4515); pfam14988"
                     /db_xref="CDD:405647"
     Region          12..>256
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     CDS             1..425
                     /gene="BBOF1"
                     /gene_synonym="C14orf45; CCDC176; FBB10"
                     /coded_by="XM_047431780.1:322..1599"
                     /db_xref="GeneID:80127"
                     /db_xref="HGNC:HGNC:19855"
                     /db_xref="MIM:620496"
ORIGIN      
        1 mihtelkavr qfqkrkiqve relddlkenl rnterihqet lrrlesrffe ekhrleqeae
       61 kkiimlaera hheaivqlnd agrnvfkend ylqkalayhl ketdalqkns qklqeshtll
      121 lhqkeindll vkekimqlvq qrsqiqtlqk kvvnletals ymtkefesev lklqqhamie
      181 nqagqveidk lqhllqmkdr emnrvkklak nilderteve rffldalhqv kqqilisrkh
      241 ykqiaqaafn lkmraactgr teypkirtfd grehstnsvn qdlleaekwt hiegnvdigd
      301 ltweqkekvl rllfakmngc psrkynqssr ppvpdyvvsd sgetkefgde sklqdkifit
      361 qqiaisdssg evvlptipke pqesdtvrsl ylikqcills pfpmsllaks rlfsllverl
      421 qgsve
//
LOCUS       XP_016877149             421 aa            linear   PRI 05-AUG-2025
DEFINITION  basal body-orientation factor 1 isoform X11 [Homo sapiens].
ACCESSION   XP_016877149
VERSION     XP_016877149.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021660.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..421
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..421
                     /product="basal body-orientation factor 1 isoform X11"
                     /calculated_mol_wt=49087
     Region          <1..130
                     /region_name="DUF4515"
                     /note="Domain of unknown function (DUF4515); pfam14988"
                     /db_xref="CDD:405647"
     Region          12..>256
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     CDS             1..421
                     /gene="BBOF1"
                     /gene_synonym="C14orf45; CCDC176; FBB10"
                     /coded_by="XM_017021660.2:322..1587"
                     /db_xref="GeneID:80127"
                     /db_xref="HGNC:HGNC:19855"
                     /db_xref="MIM:620496"
ORIGIN      
        1 mihtelkavr qfqkrkiqve relddlkenl rnterihqet lrrlesrffe ekhrleqeae
       61 kkiimlaera hheaivqlnd agrnvfkend ylqkalayhl ketdalqkns qklqeshtll
      121 lhqkeindll vkekimqlvq qrsqiqtlqk kvvnletals ymtkefesev lklqqhamie
      181 nqagqveidk lqhllqmkdr emnrvkklak nilderteve rffldalhqv kqqilisrkh
      241 ykqiaqaafn lkmraactgr teypkirtfd grehstnsvn qdlleaekwt hiegnvdigd
      301 ltweqkekvl rllfakmngc psrkynqssr ppvpdyvvsd sgetkefgde sklqdkifit
      361 qqiaisdssg evvlptipke pqesdtvrrn llrstdydlt daagspflae slllnifkki
      421 s
//
LOCUS       XP_011535481             397 aa            linear   PRI 05-AUG-2025
DEFINITION  basal body-orientation factor 1 isoform X12 [Homo sapiens].
ACCESSION   XP_011535481
VERSION     XP_011535481.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537179.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..397
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..397
                     /product="basal body-orientation factor 1 isoform X12"
                     /calculated_mol_wt=45276
     Region          <1..60
                     /region_name="DUF4515"
                     /note="Domain of unknown function (DUF4515); pfam14988"
                     /db_xref="CDD:405647"
     CDS             1..397
                     /gene="BBOF1"
                     /gene_synonym="C14orf45; CCDC176; FBB10"
                     /coded_by="XM_011537179.3:370..1563"
                     /db_xref="GeneID:80127"
                     /db_xref="HGNC:HGNC:19855"
                     /db_xref="MIM:620496"
ORIGIN      
        1 mlaerahhea ivqlndagrn vfkendylqk alayhlketd alqknsqklq eshtlllhqk
       61 swslshlgih lavsnspdis gittqgfils pkggleeind llvkekimql vqqrsqiqtl
      121 qkkvvnleta lsymtkefes evlklqqham ienqagqvei dklqhllqmk dremnrvkkl
      181 aknilderte verffldalh qvkqqilisr khykqiaqaa fnlkmraact grteypkirt
      241 fdgrehstns vnqdlleaek wthiegnvdi gdltweqkek vlrllfakmn gcpsrkynqs
      301 srppvpdyvv sdsgetkefg desklqdkif itqqiaisds sgevvlptip kepqesdtvr
      361 slylikqcil lspfpmslla ksrlfsllve rlqgsve
//
LOCUS       XP_016877150             389 aa            linear   PRI 05-AUG-2025
DEFINITION  basal body-orientation factor 1 isoform X13 [Homo sapiens].
ACCESSION   XP_016877150
VERSION     XP_016877150.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021661.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..389
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..389
                     /product="basal body-orientation factor 1 isoform X13"
                     /calculated_mol_wt=45472
     Region          <1..130
                     /region_name="DUF4515"
                     /note="Domain of unknown function (DUF4515); pfam14988"
                     /db_xref="CDD:405647"
     Region          12..>256
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     CDS             1..389
                     /gene="BBOF1"
                     /gene_synonym="C14orf45; CCDC176; FBB10"
                     /coded_by="XM_017021661.2:322..1491"
                     /db_xref="GeneID:80127"
                     /db_xref="HGNC:HGNC:19855"
                     /db_xref="MIM:620496"
ORIGIN      
        1 mihtelkavr qfqkrkiqve relddlkenl rnterihqet lrrlesrffe ekhrleqeae
       61 kkiimlaera hheaivqlnd agrnvfkend ylqkalayhl ketdalqkns qklqeshtll
      121 lhqkeindll vkekimqlvq qrsqiqtlqk kvvnletals ymtkefesev lklqqhamie
      181 nqagqveidk lqhllqmkdr emnrvkklak nilderteve rffldalhqv kqqilisrkh
      241 ykqiaqaafn lkmraactgr teypkirtfd grehstnsvn qdlleaekwt hiegnvdigd
      301 ltweqkekvl rllfakmngc psrkynqssr ppvpdyvvsd sgetkefgde sklqdkifit
      361 qqiaisdssg evvlptipke pqesdtgtf
//
LOCUS       XP_047287737             361 aa            linear   PRI 05-AUG-2025
DEFINITION  basal body-orientation factor 1 isoform X14 [Homo sapiens].
ACCESSION   XP_047287737
VERSION     XP_047287737.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431781.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..361
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..361
                     /product="basal body-orientation factor 1 isoform X14"
                     /calculated_mol_wt=41150
     Region          <1..60
                     /region_name="DUF4515"
                     /note="Domain of unknown function (DUF4515); pfam14988"
                     /db_xref="CDD:405647"
     CDS             1..361
                     /gene="BBOF1"
                     /gene_synonym="C14orf45; CCDC176; FBB10"
                     /coded_by="XM_047431781.1:370..1455"
                     /db_xref="GeneID:80127"
                     /db_xref="HGNC:HGNC:19855"
                     /db_xref="MIM:620496"
ORIGIN      
        1 mlaerahhea ivqlndagrn vfkendylqk alayhlketd alqknsqklq eshtlllhqk
       61 swslshlgih lavsnspdis gittqgfils pkggleeind llvkekimql vqqrsqiqtl
      121 qkkvvnleta lsymtkefes evlklqqham ienqagqvei dklqhllqmk dremnrvkkl
      181 aknilderte verffldalh qvkqqilisr khykqiaqaa fnlkmraact grteypkirt
      241 fdgrehstns vnqdlleaek wthiegnvdi gdltweqkek vlrllfakmn gcpsrkynqs
      301 srppvpdyvv sdsgetkefg desklqdkif itqqiaisds sgevvlptip kepqesdtgt
      361 f
//
LOCUS       XP_047287738             361 aa            linear   PRI 05-AUG-2025
DEFINITION  basal body-orientation factor 1 isoform X15 [Homo sapiens].
ACCESSION   XP_047287738
VERSION     XP_047287738.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431782.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..361
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..361
                     /product="basal body-orientation factor 1 isoform X15"
                     /calculated_mol_wt=41574
     Region          <1..66
                     /region_name="DUF4515"
                     /note="Domain of unknown function (DUF4515); pfam14988"
                     /db_xref="CDD:405647"
     Region          <11..>170
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..361
                     /gene="BBOF1"
                     /gene_synonym="C14orf45; CCDC176; FBB10"
                     /coded_by="XM_047431782.1:370..1455"
                     /db_xref="GeneID:80127"
                     /db_xref="HGNC:HGNC:19855"
                     /db_xref="MIM:620496"
ORIGIN      
        1 mlaerahhea ivqlndagrn vfkendylqk alayhlketd alqknsqklq eshtlllhqk
       61 eindllvkek imqlvqqrsq iqtlqkkvvn letalsymtk efesevlklq qhamienqag
      121 qveidklqhl lqmkdremnr vkklaknild erteverffl dalhqvkqqi lisrkhykqi
      181 aqaafnlkmr aactgrteyp kirtfdgreh stnsvnqdll eaekwthieg nvdigdltwe
      241 qkekvlrllf akmngcpsrk ynqssrppvp dyvvsdsget kefgdesklq dkifitqqia
      301 isdssgevvl ptipkepqes dtvrslylik qcillspfpm sllaksrlfs llverlqgsv
      361 e
//
LOCUS       XP_047287739             352 aa            linear   PRI 05-AUG-2025
DEFINITION  basal body-orientation factor 1 isoform X16 [Homo sapiens].
ACCESSION   XP_047287739
VERSION     XP_047287739.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431783.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..352
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..352
                     /product="basal body-orientation factor 1 isoform X16"
                     /calculated_mol_wt=40905
     Region          77..>213
                     /region_name="DUF4515"
                     /note="Domain of unknown function (DUF4515); pfam14988"
                     /db_xref="CDD:405647"
     CDS             1..352
                     /gene="BBOF1"
                     /gene_synonym="C14orf45; CCDC176; FBB10"
                     /coded_by="XM_047431783.1:131..1189"
                     /db_xref="GeneID:80127"
                     /db_xref="HGNC:HGNC:19855"
                     /db_xref="MIM:620496"
ORIGIN      
        1 mpskgkdkkk gkskgkdtkk liktdesvvd rakanaslwe arlevtelsr ikyrdtsril
       61 aksnedlkkk qckmekdims vlsylkkqdq ekdnmieklk qqlnetkeka qeekdkleqk
      121 ytrqineleg qfhqkakeig mihtelkavr qfqkrkiqve relddlkenl rnterihqet
      181 lrrlesrffe ekhrleqeae kkiimlaera hheaivthie gnvdigdltw eqkekvlrll
      241 fakmngcpsr kynqssrppv pdyvvsdsge tkefgdeskl qdkifitqqi aisdssgevv
      301 lptipkepqe sdtvrslyli kqcillspfp msllaksrlf sllverlqgs ve
//
LOCUS       XP_016877151             325 aa            linear   PRI 05-AUG-2025
DEFINITION  basal body-orientation factor 1 isoform X17 [Homo sapiens].
ACCESSION   XP_016877151
VERSION     XP_016877151.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021662.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..325
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..325
                     /product="basal body-orientation factor 1 isoform X17"
                     /calculated_mol_wt=37448
     Region          <1..66
                     /region_name="DUF4515"
                     /note="Domain of unknown function (DUF4515); pfam14988"
                     /db_xref="CDD:405647"
     Region          <11..>170
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..325
                     /gene="BBOF1"
                     /gene_synonym="C14orf45; CCDC176; FBB10"
                     /coded_by="XM_017021662.2:370..1347"
                     /db_xref="GeneID:80127"
                     /db_xref="HGNC:HGNC:19855"
                     /db_xref="MIM:620496"
ORIGIN      
        1 mlaerahhea ivqlndagrn vfkendylqk alayhlketd alqknsqklq eshtlllhqk
       61 eindllvkek imqlvqqrsq iqtlqkkvvn letalsymtk efesevlklq qhamienqag
      121 qveidklqhl lqmkdremnr vkklaknild erteverffl dalhqvkqqi lisrkhykqi
      181 aqaafnlkmr aactgrteyp kirtfdgreh stnsvnqdll eaekwthieg nvdigdltwe
      241 qkekvlrllf akmngcpsrk ynqssrppvp dyvvsdsget kefgdesklq dkifitqqia
      301 isdssgevvl ptipkepqes dtgtf
//
LOCUS       XP_016877152             316 aa            linear   PRI 05-AUG-2025
DEFINITION  basal body-orientation factor 1 isoform X18 [Homo sapiens].
ACCESSION   XP_016877152
VERSION     XP_016877152.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021663.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..316
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..316
                     /product="basal body-orientation factor 1 isoform X18"
                     /calculated_mol_wt=36779
     Region          77..>213
                     /region_name="DUF4515"
                     /note="Domain of unknown function (DUF4515); pfam14988"
                     /db_xref="CDD:405647"
     CDS             1..316
                     /gene="BBOF1"
                     /gene_synonym="C14orf45; CCDC176; FBB10"
                     /coded_by="XM_017021663.2:131..1081"
                     /db_xref="GeneID:80127"
                     /db_xref="HGNC:HGNC:19855"
                     /db_xref="MIM:620496"
ORIGIN      
        1 mpskgkdkkk gkskgkdtkk liktdesvvd rakanaslwe arlevtelsr ikyrdtsril
       61 aksnedlkkk qckmekdims vlsylkkqdq ekdnmieklk qqlnetkeka qeekdkleqk
      121 ytrqineleg qfhqkakeig mihtelkavr qfqkrkiqve relddlkenl rnterihqet
      181 lrrlesrffe ekhrleqeae kkiimlaera hheaivthie gnvdigdltw eqkekvlrll
      241 fakmngcpsr kynqssrppv pdyvvsdsge tkefgdeskl qdkifitqqi aisdssgevv
      301 lptipkepqe sdtgtf
//
LOCUS       XP_047287740             303 aa            linear   PRI 05-AUG-2025
DEFINITION  basal body-orientation factor 1 isoform X19 [Homo sapiens].
ACCESSION   XP_047287740
VERSION     XP_047287740.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431784.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..303
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..303
                     /product="basal body-orientation factor 1 isoform X19"
                     /calculated_mol_wt=35294
     Region          77..>192
                     /region_name="DUF4515"
                     /note="Domain of unknown function (DUF4515); pfam14988"
                     /db_xref="CDD:405647"
     CDS             1..303
                     /gene="BBOF1"
                     /gene_synonym="C14orf45; CCDC176; FBB10"
                     /coded_by="XM_047431784.1:131..1042"
                     /db_xref="GeneID:80127"
                     /db_xref="HGNC:HGNC:19855"
                     /db_xref="MIM:620496"
ORIGIN      
        1 mpskgkdkkk gkskgkdtkk liktdesvvd rakanaslwe arlevtelsr ikyrdtsril
       61 aksnedlkkk qckmekdims vlsylkkqdq ekdnmieklk qqlnetkeka qeekdkleqk
      121 ytrqineleg qfhqkakeig mihtelkavr qfqkrkiqve relddlkenl rnterihqet
      181 lrrlesrffe ekglalsprl eyigiimvhc ilhclgssdp ltsasrvagt tgmchhaqli
      241 fvffvetgfc pgwsrtpglk qstrlglpkc wdyrceslyq atflnflevk flqlkvgliy
      301 ffq
//
LOCUS       XP_047287741             267 aa            linear   PRI 05-AUG-2025
DEFINITION  basal body-orientation factor 1 isoform X20 [Homo sapiens].
ACCESSION   XP_047287741
VERSION     XP_047287741.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431785.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..267
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..267
                     /product="basal body-orientation factor 1 isoform X20"
                     /calculated_mol_wt=31636
     Region          77..264
                     /region_name="DUF4515"
                     /note="Domain of unknown function (DUF4515); pfam14988"
                     /db_xref="CDD:405647"
     CDS             1..267
                     /gene="BBOF1"
                     /gene_synonym="C14orf45; CCDC176; FBB10"
                     /coded_by="XM_047431785.1:131..934"
                     /db_xref="GeneID:80127"
                     /db_xref="HGNC:HGNC:19855"
                     /db_xref="MIM:620496"
ORIGIN      
        1 mpskgkdkkk gkskgkdtkk liktdesvvd rakanaslwe arlevtelsr ikyrdtsril
       61 aksnedlkkk qckmekdims vlsylkkqdq ekdnmieklk qqlnetkeka qeekdkleqk
      121 ytrqineleg qfhqkakeig mihtelkavr qfqkrkiqve relddlkenl rnterihqet
      181 lrrlesrffe ekhrleqeae kkiimlaera hheaivqlnd agrnvfkend ylqkalayhl
      241 ketdalqkns qklqeshtll lhqkdty
//
LOCUS       XP_011535483             214 aa            linear   PRI 05-AUG-2025
DEFINITION  iron-sulfur cluster transfer protein NUBPL isoform X1 [Homo
            sapiens].
ACCESSION   XP_011535483
VERSION     XP_011535483.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537181.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..214
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..214
                     /product="iron-sulfur cluster transfer protein NUBPL
                     isoform X1"
                     /calculated_mol_wt=23496
     Region          <37..206
                     /region_name="ParA"
                     /note="NUBPL iron-transfer P-loop NTPase; pfam10609"
                     /db_xref="CDD:431392"
     CDS             1..214
                     /gene="NUBPL"
                     /gene_synonym="C14orf127; huInd1; IND1; MC1DN21"
                     /coded_by="XM_011537181.3:95..739"
                     /db_xref="GeneID:80224"
                     /db_xref="HGNC:HGNC:20278"
                     /db_xref="MIM:613621"
ORIGIN      
        1 mnsvnvqghw farcgcvwtf sskddeserk sgiitdmsmg flveesepvv wrglmvmsai
       61 ekllrqvdwg qldylvvdmp pgtgdvqlsv sqnipitgav ivstpqdial mdahkgaemf
      121 rrvhvpvlgl vqnmsvfqcp kckhkthifg adgarklaqt lglevlgdip lhlnireasd
      181 tgqpivfsqp esdeakaylr iavevvrrlp spse
//
LOCUS       XP_016877153             197 aa            linear   PRI 05-AUG-2025
DEFINITION  iron-sulfur cluster transfer protein NUBPL isoform X2 [Homo
            sapiens].
ACCESSION   XP_016877153
VERSION     XP_016877153.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021664.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..197
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..197
                     /product="iron-sulfur cluster transfer protein NUBPL
                     isoform X2"
                     /calculated_mol_wt=20911
     Region          65..>173
                     /region_name="P-loop containing Nucleoside Triphosphate
                     Hydrolases"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; cl38936"
                     /db_xref="CDD:476819"
     CDS             1..197
                     /gene="NUBPL"
                     /gene_synonym="C14orf127; huInd1; IND1; MC1DN21"
                     /coded_by="XM_017021664.2:37..630"
                     /db_xref="GeneID:80224"
                     /db_xref="HGNC:HGNC:20278"
                     /db_xref="MIM:613621"
ORIGIN      
        1 mgiwqrlllf ggvslraggg ataplggsra mvcgrqlsga gsetlkqrrt qimsrglpkq
       61 kpiegvkqvi vvasgkggvg ksttavnlal alaandsska iglldvdvyg psvpkmmnlk
      121 gnpelsqsnl mrpllnygia cmsmgflvee sepvvwrglm vmsaiekllr qcymrvslas
      181 ksklestflf cfvkylv
//
LOCUS       XP_047287742             189 aa            linear   PRI 05-AUG-2025
DEFINITION  iron-sulfur cluster transfer protein NUBPL isoform X3 [Homo
            sapiens].
ACCESSION   XP_047287742
VERSION     XP_047287742.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431786.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..189
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..189
                     /product="iron-sulfur cluster transfer protein NUBPL
                     isoform X3"
                     /calculated_mol_wt=20655
     Region          <1..181
                     /region_name="ParA"
                     /note="NUBPL iron-transfer P-loop NTPase; pfam10609"
                     /db_xref="CDD:431392"
     CDS             1..189
                     /gene="NUBPL"
                     /gene_synonym="C14orf127; huInd1; IND1; MC1DN21"
                     /coded_by="XM_047431786.1:123..692"
                     /db_xref="GeneID:80224"
                     /db_xref="HGNC:HGNC:20278"
                     /db_xref="MIM:613621"
ORIGIN      
        1 mrpllnygia cmsmgflvee sepvvwrglm vmsaiekllr qvdwgqldyl vvdmppgtgd
       61 vqlsvsqnip itgavivstp qdialmdahk gaemfrrvhv pvlglvqnms vfqcpkckhk
      121 thifgadgar klaqtlglev lgdiplhlni reasdtgqpi vfsqpesdea kaylriavev
      181 vrrlpspse
//
LOCUS       XP_016877154             185 aa            linear   PRI 05-AUG-2025
DEFINITION  iron-sulfur cluster transfer protein NUBPL isoform X4 [Homo
            sapiens].
ACCESSION   XP_016877154
VERSION     XP_016877154.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021665.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..185
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..185
                     /product="iron-sulfur cluster transfer protein NUBPL
                     isoform X4"
                     /calculated_mol_wt=19489
     Region          65..>171
                     /region_name="P-loop containing Nucleoside Triphosphate
                     Hydrolases"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; cl38936"
                     /db_xref="CDD:476819"
     CDS             1..185
                     /gene="NUBPL"
                     /gene_synonym="C14orf127; huInd1; IND1; MC1DN21"
                     /coded_by="XM_017021665.3:37..594"
                     /db_xref="GeneID:80224"
                     /db_xref="HGNC:HGNC:20278"
                     /db_xref="MIM:613621"
ORIGIN      
        1 mgiwqrlllf ggvslraggg ataplggsra mvcgrqlsga gsetlkqrrt qimsrglpkq
       61 kpiegvkqvi vvasgkggvg ksttavnlal alaandsska iglldvdvyg psvpkmmnlk
      121 gnpelsqsnl mrpllnygia cmsmgflvee sepvvwrglm vmsaiekllr qpistrgtlr
      181 lkirm
//
LOCUS       XP_011535485             181 aa            linear   PRI 05-AUG-2025
DEFINITION  iron-sulfur cluster transfer protein NUBPL isoform X5 [Homo
            sapiens].
ACCESSION   XP_011535485
VERSION     XP_011535485.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537183.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..181
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..181
                     /product="iron-sulfur cluster transfer protein NUBPL
                     isoform X5"
                     /calculated_mol_wt=18981
     Region          65..>171
                     /region_name="P-loop containing Nucleoside Triphosphate
                     Hydrolases"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; cl38936"
                     /db_xref="CDD:476819"
     CDS             1..181
                     /gene="NUBPL"
                     /gene_synonym="C14orf127; huInd1; IND1; MC1DN21"
                     /coded_by="XM_011537183.3:37..582"
                     /db_xref="GeneID:80224"
                     /db_xref="HGNC:HGNC:20278"
                     /db_xref="MIM:613621"
ORIGIN      
        1 mgiwqrlllf ggvslraggg ataplggsra mvcgrqlsga gsetlkqrrt qimsrglpkq
       61 kpiegvkqvi vvasgkggvg ksttavnlal alaandsska iglldvdvyg psvpkmmnlk
      121 gnpelsqsnl mrpllnygia cmsmgflvee sepvvwrglm vmsaiekllr qhkgphkmlv
      181 s
//
LOCUS       XP_016877155             181 aa            linear   PRI 05-AUG-2025
DEFINITION  iron-sulfur cluster transfer protein NUBPL isoform X6 [Homo
            sapiens].
ACCESSION   XP_016877155
VERSION     XP_016877155.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021666.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..181
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..181
                     /product="iron-sulfur cluster transfer protein NUBPL
                     isoform X6"
                     /calculated_mol_wt=18950
     Region          65..>171
                     /region_name="P-loop containing Nucleoside Triphosphate
                     Hydrolases"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; cl38936"
                     /db_xref="CDD:476819"
     CDS             1..181
                     /gene="NUBPL"
                     /gene_synonym="C14orf127; huInd1; IND1; MC1DN21"
                     /coded_by="XM_017021666.2:37..582"
                     /db_xref="GeneID:80224"
                     /db_xref="HGNC:HGNC:20278"
                     /db_xref="MIM:613621"
ORIGIN      
        1 mgiwqrlllf ggvslraggg ataplggsra mvcgrqlsga gsetlkqrrt qimsrglpkq
       61 kpiegvkqvi vvasgkggvg ksttavnlal alaandsska iglldvdvyg psvpkmmnlk
      121 gnpelsqsnl mrpllnygia cmsmgflvee sepvvwrglm vmsaiekllr qpqitlttii
      181 c
//
LOCUS       XP_047287743             178 aa            linear   PRI 05-AUG-2025
DEFINITION  iron-sulfur cluster transfer protein NUBPL isoform X7 [Homo
            sapiens].
ACCESSION   XP_047287743
VERSION     XP_047287743.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431787.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..178
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..178
                     /product="iron-sulfur cluster transfer protein NUBPL
                     isoform X7"
                     /calculated_mol_wt=19423
     Region          <1..170
                     /region_name="ParA"
                     /note="NUBPL iron-transfer P-loop NTPase; pfam10609"
                     /db_xref="CDD:431392"
     CDS             1..178
                     /gene="NUBPL"
                     /gene_synonym="C14orf127; huInd1; IND1; MC1DN21"
                     /coded_by="XM_047431787.1:122..658"
                     /db_xref="GeneID:80224"
                     /db_xref="HGNC:HGNC:20278"
                     /db_xref="MIM:613621"
ORIGIN      
        1 msmgflvees epvvwrglmv msaiekllrq vdwgqldylv vdmppgtgdv qlsvsqnipi
       61 tgavivstpq dialmdahkg aemfrrvhvp vlglvqnmsv fqcpkckhkt hifgadgark
      121 laqtlglevl gdiplhlnir easdtgqpiv fsqpesdeak aylriavevv rrlpspse
//
LOCUS       XP_047287744             173 aa            linear   PRI 05-AUG-2025
DEFINITION  iron-sulfur cluster transfer protein NUBPL isoform X8 [Homo
            sapiens].
ACCESSION   XP_047287744
VERSION     XP_047287744.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431788.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..173
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..173
                     /product="iron-sulfur cluster transfer protein NUBPL
                     isoform X8"
                     /calculated_mol_wt=18077
     Region          65..>172
                     /region_name="P-loop containing Nucleoside Triphosphate
                     Hydrolases"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; cl38936"
                     /db_xref="CDD:476819"
     CDS             1..173
                     /gene="NUBPL"
                     /gene_synonym="C14orf127; huInd1; IND1; MC1DN21"
                     /coded_by="XM_047431788.1:37..558"
                     /db_xref="GeneID:80224"
                     /db_xref="HGNC:HGNC:20278"
                     /db_xref="MIM:613621"
ORIGIN      
        1 mgiwqrlllf ggvslraggg ataplggsra mvcgrqlsga gsetlkqrrt qimsrglpkq
       61 kpiegvkqvi vvasgkggvg ksttavnlal alaandsska iglldvdvyg psvpkmmnlk
      121 gnpelsqsnl mrpllnygia cmsmgflvee sepvvwrglm vmsaiekllr qvl
//
LOCUS       XP_047287745             165 aa            linear   PRI 05-AUG-2025
DEFINITION  iron-sulfur cluster transfer protein NUBPL isoform X9 [Homo
            sapiens].
ACCESSION   XP_047287745
VERSION     XP_047287745.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431789.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..165
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..165
                     /product="iron-sulfur cluster transfer protein NUBPL
                     isoform X9"
                     /calculated_mol_wt=16759
     Region          65..>129
                     /region_name="P-loop containing Nucleoside Triphosphate
                     Hydrolases"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; cl38936"
                     /db_xref="CDD:476819"
     CDS             1..165
                     /gene="NUBPL"
                     /gene_synonym="C14orf127; huInd1; IND1; MC1DN21"
                     /coded_by="XM_047431789.1:37..534"
                     /db_xref="GeneID:80224"
                     /db_xref="HGNC:HGNC:20278"
                     /db_xref="MIM:613621"
ORIGIN      
        1 mgiwqrlllf ggvslraggg ataplggsra mvcgrqlsga gsetlkqrrt qimsrglpkq
       61 kpiegvkqvi vvasgkggvg ksttavnlal alaandsska iglldvdvyg psvpkmmnlk
      121 gnpelsqsgv sllspgwsav vrsqvtatsa sqvpvqaill fqppk
//
LOCUS       XP_011535486             136 aa            linear   PRI 05-AUG-2025
DEFINITION  iron-sulfur cluster transfer protein NUBPL isoform X10 [Homo
            sapiens].
ACCESSION   XP_011535486
VERSION     XP_011535486.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537184.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..136
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..136
                     /product="iron-sulfur cluster transfer protein NUBPL
                     isoform X10"
                     /calculated_mol_wt=14570
     Region          <1..128
                     /region_name="P-loop containing Nucleoside Triphosphate
                     Hydrolases"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; cl38936"
                     /db_xref="CDD:476819"
     CDS             1..136
                     /gene="NUBPL"
                     /gene_synonym="C14orf127; huInd1; IND1; MC1DN21"
                     /coded_by="XM_011537184.4:3979..4389"
                     /db_xref="GeneID:80224"
                     /db_xref="HGNC:HGNC:20278"
                     /db_xref="MIM:613621"
ORIGIN      
        1 mppgtgdvql svsqnipitg avivstpqdi almdahkgae mfrrvhvpvl glvqnmsvfq
       61 cpkckhkthi fgadgarkla qtlglevlgd iplhlnirea sdtgqpivfs qpesdeakay
      121 lriavevvrr lpspse
//
LOCUS       XP_011535490             941 aa            linear   PRI 05-AUG-2025
DEFINITION  phospholipase DDHD1 isoform X1 [Homo sapiens].
ACCESSION   XP_011535490
VERSION     XP_011535490.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537188.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..941
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..941
                     /product="phospholipase DDHD1 isoform X1"
                     /calculated_mol_wt=105039
     Region          652..926
                     /region_name="DDHD"
                     /note="DDHD domain; pfam02862"
                     /db_xref="CDD:460725"
     CDS             1..941
                     /gene="DDHD1"
                     /gene_synonym="iPLA1alpha; iPLA1I; PA-PLA1; PAPLA1; SPG28"
                     /coded_by="XM_011537188.3:226..3051"
                     /db_xref="GeneID:80821"
                     /db_xref="HGNC:HGNC:19714"
                     /db_xref="MIM:614603"
ORIGIN      
        1 mnypgrgspr spehngrggg ggawelgsda rpafgggvcc fehlpggdpd dgdvplallr
       61 gepglhlapg tddhnhhlal dpclsdenyd fssaesgssl ryysegesgg ggsslslhpp
      121 qqpplvptns ggggatggsp gerkrtrlgg paarhryevv telgpeevrw fykedkktwk
      181 pfigydslri elafrtllqt tgarpqggdr dgdhvcsptg passsgeddd edracgfcqs
      241 ttghepemve lvniepvcvr gglyevdvtq gecypvywnq adkipvmrgq wfidgtwqpl
      301 eeeesnlieq ehlncfrgqq mqenfdievs ksidgkdgsg inysvvyhlp pfslpslfkw
      361 rrykestdat glkrkhsqav hsfklsrnhv dwhsvdevyl ysdattskia rtvtqklgfs
      421 kasssgtrlh rgyveeatle dkpsqtthiv fvvhgigqkm dqgriiknta mmreaarkie
      481 erhfsnhath veflpvewrs kltldgdtvd sitpdkvrgl rdmlnssamd imyytsplyr
      541 delvkglqqe lnrlyslfcs rnpdfeekgg kvsivshslg cvitydimtg wnpvrlyeql
      601 lqkeeelpde rwmsyeerhl ldelyitkrr lkeieerlhg lkassmtqtp alkfkvenff
      661 cmgsplavfl alrgirpgnt gsqdhilpre icnrllnifh ptdpvayrle plilkhysni
      721 spvqihwynt snplpyehmk psflnpakep tsvsenegis tipspvtspv lsrrhygesi
      781 tnigkasilg aasigkglgg mlfsrfgrss ttqssetskd smedekkpva spsattvgtq
      841 tlphsssgfl dsayfrlqes ffnlpqllfp envmqnkdna lveldhridf elreglvesr
      901 ywsavtshta ywssldvalf lltfmykheh dddakpnldp i
//
LOCUS       XP_005268159             934 aa            linear   PRI 05-AUG-2025
DEFINITION  phospholipase DDHD1 isoform X2 [Homo sapiens].
ACCESSION   XP_005268159
VERSION     XP_005268159.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005268102.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..934
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..934
                     /product="phospholipase DDHD1 isoform X2"
                     /calculated_mol_wt=104360
     Region          645..919
                     /region_name="DDHD"
                     /note="DDHD domain; pfam02862"
                     /db_xref="CDD:460725"
     CDS             1..934
                     /gene="DDHD1"
                     /gene_synonym="iPLA1alpha; iPLA1I; PA-PLA1; PAPLA1; SPG28"
                     /coded_by="XM_005268102.3:226..3030"
                     /db_xref="GeneID:80821"
                     /db_xref="HGNC:HGNC:19714"
                     /db_xref="MIM:614603"
ORIGIN      
        1 mnypgrgspr spehngrggg ggawelgsda rpafgggvcc fehlpggdpd dgdvplallr
       61 gepglhlapg tddhnhhlal dpclsdenyd fssaesgssl ryysegesgg ggsslslhpp
      121 qqpplvptns ggggatggsp gerkrtrlgg paarhryevv telgpeevrw fykedkktwk
      181 pfigydslri elafrtllqt tgarpqggdr dgdhvcsptg passsgeddd edracgfcqs
      241 ttghepemve lvniepvcvr gglyevdvtq gecypvywnq adkipvmrgq wfidgtwqpl
      301 eeeesnlieq ehlncfrgqq mqenfdievs ksidgkdvvy hlppfslpsl fkwrrykest
      361 datglkrkhs qavhsfklsr nhvdwhsvde vylysdatts kiartvtqkl gfskasssgt
      421 rlhrgyveea tledkpsqtt hivfvvhgig qkmdqgriik ntammreaar kieerhfsnh
      481 athveflpve wrskltldgd tvdsitpdkv rglrdmlnss amdimyytsp lyrdelvkgl
      541 qqelnrlysl fcsrnpdfee kggkvsivsh slgcvitydi mtgwnpvrly eqllqkeeel
      601 pderwmsyee rhlldelyit krrlkeieer lhglkassmt qtpalkfkve nffcmgspla
      661 vflalrgirp gntgsqdhil preicnrlln ifhptdpvay rleplilkhy snispvqihw
      721 yntsnplpye hmkpsflnpa keptsvsene gistipspvt spvlsrrhyg esitnigkas
      781 ilgaasigkg lggmlfsrfg rssttqsset skdsmedekk pvaspsattv gtqtlphsss
      841 gfldsayfrl qesffnlpql lfpenvmqnk dnalveldhr idfelreglv esrywsavts
      901 htaywssldv alflltfmyk hehdddakpn ldpi
//
LOCUS       XP_011535491             913 aa            linear   PRI 05-AUG-2025
DEFINITION  phospholipase DDHD1 isoform X3 [Homo sapiens].
ACCESSION   XP_011535491
VERSION     XP_011535491.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537189.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..913
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..913
                     /product="phospholipase DDHD1 isoform X3"
                     /calculated_mol_wt=101654
     Region          652..898
                     /region_name="DDHD"
                     /note="DDHD domain; pfam02862"
                     /db_xref="CDD:460725"
     CDS             1..913
                     /gene="DDHD1"
                     /gene_synonym="iPLA1alpha; iPLA1I; PA-PLA1; PAPLA1; SPG28"
                     /coded_by="XM_011537189.3:226..2967"
                     /db_xref="GeneID:80821"
                     /db_xref="HGNC:HGNC:19714"
                     /db_xref="MIM:614603"
ORIGIN      
        1 mnypgrgspr spehngrggg ggawelgsda rpafgggvcc fehlpggdpd dgdvplallr
       61 gepglhlapg tddhnhhlal dpclsdenyd fssaesgssl ryysegesgg ggsslslhpp
      121 qqpplvptns ggggatggsp gerkrtrlgg paarhryevv telgpeevrw fykedkktwk
      181 pfigydslri elafrtllqt tgarpqggdr dgdhvcsptg passsgeddd edracgfcqs
      241 ttghepemve lvniepvcvr gglyevdvtq gecypvywnq adkipvmrgq wfidgtwqpl
      301 eeeesnlieq ehlncfrgqq mqenfdievs ksidgkdgsg inysvvyhlp pfslpslfkw
      361 rrykestdat glkrkhsqav hsfklsrnhv dwhsvdevyl ysdattskia rtvtqklgfs
      421 kasssgtrlh rgyveeatle dkpsqtthiv fvvhgigqkm dqgriiknta mmreaarkie
      481 erhfsnhath veflpvewrs kltldgdtvd sitpdkvrgl rdmlnssamd imyytsplyr
      541 delvkglqqe lnrlyslfcs rnpdfeekgg kvsivshslg cvitydimtg wnpvrlyeql
      601 lqkeeelpde rwmsyeerhl ldelyitkrr lkeieerlhg lkassmtqtp alkfkvenff
      661 cmgsplavfl alrgirpgnt gsqdhilpre icnrllnifh ptdpvayrle plilkhysni
      721 spvqihwynt snplpyehmk psflnpakep tsvsenegis tipspvtspv lsrrhygesi
      781 tnigkasilg aasigkglgg mlfsrfgrss ttqssetskd smedekkpva spsattvgtq
      841 tlphsssgfl dsaleldhri dfelreglve srywsavtsh taywssldva lflltfmykh
      901 ehdddakpnl dpi
//
LOCUS       XP_005268160             907 aa            linear   PRI 05-AUG-2025
DEFINITION  phospholipase DDHD1 isoform X4 [Homo sapiens].
ACCESSION   XP_005268160
VERSION     XP_005268160.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005268103.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..907
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..907
                     /product="phospholipase DDHD1 isoform X4"
                     /calculated_mol_wt=100983
     Region          618..892
                     /region_name="DDHD"
                     /note="DDHD domain; pfam02862"
                     /db_xref="CDD:460725"
     CDS             1..907
                     /gene="DDHD1"
                     /gene_synonym="iPLA1alpha; iPLA1I; PA-PLA1; PAPLA1; SPG28"
                     /coded_by="XM_005268103.3:226..2949"
                     /db_xref="GeneID:80821"
                     /db_xref="HGNC:HGNC:19714"
                     /db_xref="MIM:614603"
ORIGIN      
        1 mnypgrgspr spehngrggg ggawelgsda rpafgggvcc fehlpggdpd dgdvplallr
       61 gepglhlapg tddhnhhlal dpclsdenyd fssaesgssl ryysegesgg ggsslslhpp
      121 qqpplvptns ggggatggsp gerkrtrlgg paarhryevv telgpeevrw fykedkktwk
      181 pfigydslri elafrtllqt tgarpqggdr dgdhvcsptg passsgeddd edracgfcqs
      241 ttghepemve lvniepvcvr gglyevdvtq gecypvywnq adkipvmrgq wfidgtwqpl
      301 eeeesnlieq ehlncfrgqq mqenfdievs ksidgkdgsg inysavhsfk lsrnhvdwhs
      361 vdevylysda ttskiartvt qklgfskass sgtrlhrgyv eeatledkps qtthivfvvh
      421 gigqkmdqgr iikntammre aarkieerhf snhathvefl pvewrskltl dgdtvdsitp
      481 dkvrglrdml nssamdimyy tsplyrdelv kglqqelnrl yslfcsrnpd feekggkvsi
      541 vshslgcvit ydimtgwnpv rlyeqllqke eelpderwms yeerhlldel yitkrrlkei
      601 eerlhglkas smtqtpalkf kvenffcmgs plavflalrg irpgntgsqd hilpreicnr
      661 llnifhptdp vayrleplil khysnispvq ihwyntsnpl pyehmkpsfl npakeptsvs
      721 enegistips pvtspvlsrr hygesitnig kasilgaasi gkglggmlfs rfgrssttqs
      781 setskdsmed ekkpvaspsa ttvgtqtlph sssgfldsay frlqesffnl pqllfpenvm
      841 qnkdnalvel dhridfelre glvesrywsa vtshtaywss ldvalflltf mykhehddda
      901 kpnldpi
//
LOCUS       XP_016877157             906 aa            linear   PRI 05-AUG-2025
DEFINITION  phospholipase DDHD1 isoform X5 [Homo sapiens].
ACCESSION   XP_016877157
VERSION     XP_016877157.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021668.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..906
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..906
                     /product="phospholipase DDHD1 isoform X5"
                     /calculated_mol_wt=100975
     Region          645..891
                     /region_name="DDHD"
                     /note="DDHD domain; pfam02862"
                     /db_xref="CDD:460725"
     CDS             1..906
                     /gene="DDHD1"
                     /gene_synonym="iPLA1alpha; iPLA1I; PA-PLA1; PAPLA1; SPG28"
                     /coded_by="XM_017021668.2:226..2946"
                     /db_xref="GeneID:80821"
                     /db_xref="HGNC:HGNC:19714"
                     /db_xref="MIM:614603"
ORIGIN      
        1 mnypgrgspr spehngrggg ggawelgsda rpafgggvcc fehlpggdpd dgdvplallr
       61 gepglhlapg tddhnhhlal dpclsdenyd fssaesgssl ryysegesgg ggsslslhpp
      121 qqpplvptns ggggatggsp gerkrtrlgg paarhryevv telgpeevrw fykedkktwk
      181 pfigydslri elafrtllqt tgarpqggdr dgdhvcsptg passsgeddd edracgfcqs
      241 ttghepemve lvniepvcvr gglyevdvtq gecypvywnq adkipvmrgq wfidgtwqpl
      301 eeeesnlieq ehlncfrgqq mqenfdievs ksidgkdvvy hlppfslpsl fkwrrykest
      361 datglkrkhs qavhsfklsr nhvdwhsvde vylysdatts kiartvtqkl gfskasssgt
      421 rlhrgyveea tledkpsqtt hivfvvhgig qkmdqgriik ntammreaar kieerhfsnh
      481 athveflpve wrskltldgd tvdsitpdkv rglrdmlnss amdimyytsp lyrdelvkgl
      541 qqelnrlysl fcsrnpdfee kggkvsivsh slgcvitydi mtgwnpvrly eqllqkeeel
      601 pderwmsyee rhlldelyit krrlkeieer lhglkassmt qtpalkfkve nffcmgspla
      661 vflalrgirp gntgsqdhil preicnrlln ifhptdpvay rleplilkhy snispvqihw
      721 yntsnplpye hmkpsflnpa keptsvsene gistipspvt spvlsrrhyg esitnigkas
      781 ilgaasigkg lggmlfsrfg rssttqsset skdsmedekk pvaspsattv gtqtlphsss
      841 gfldsaleld hridfelreg lvesrywsav tshtaywssl dvalflltfm ykhehdddak
      901 pnldpi
//
LOCUS       XP_005268162             857 aa            linear   PRI 05-AUG-2025
DEFINITION  phospholipase DDHD1 isoform X6 [Homo sapiens].
ACCESSION   XP_005268162
VERSION     XP_005268162.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005268105.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..857
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..857
                     /product="phospholipase DDHD1 isoform X6"
                     /calculated_mol_wt=95399
     Region          568..842
                     /region_name="DDHD"
                     /note="DDHD domain; pfam02862"
                     /db_xref="CDD:460725"
     CDS             1..857
                     /gene="DDHD1"
                     /gene_synonym="iPLA1alpha; iPLA1I; PA-PLA1; PAPLA1; SPG28"
                     /coded_by="XM_005268105.3:226..2799"
                     /db_xref="GeneID:80821"
                     /db_xref="HGNC:HGNC:19714"
                     /db_xref="MIM:614603"
ORIGIN      
        1 mnypgrgspr spehngrggg ggawelgsda rpafgggvcc fehlpggdpd dgdvplallr
       61 gepglhlapg tddhnhhlal dpclsdenyd fssaesgssl ryysegesgg ggsslslhpp
      121 qqpplvptns ggggatggsp gerkrtrlgg paarhryevv telgpeevrw fykedkktwk
      181 pfigydslri elafrtllqt tgarpqggdr dgdhvcsptg passsgeddd edracgfcqs
      241 ttghepemve lvniepvcvr gglyevdvtq gecypvywnq adkipvmrgq wfidgtwqpl
      301 eeeesnlieq ehlncfrgqq mqenfdievs ksidgkdass sgtrlhrgyv eeatledkps
      361 qtthivfvvh gigqkmdqgr iikntammre aarkieerhf snhathvefl pvewrskltl
      421 dgdtvdsitp dkvrglrdml nssamdimyy tsplyrdelv kglqqelnrl yslfcsrnpd
      481 feekggkvsi vshslgcvit ydimtgwnpv rlyeqllqke eelpderwms yeerhlldel
      541 yitkrrlkei eerlhglkas smtqtpalkf kvenffcmgs plavflalrg irpgntgsqd
      601 hilpreicnr llnifhptdp vayrleplil khysnispvq ihwyntsnpl pyehmkpsfl
      661 npakeptsvs enegistips pvtspvlsrr hygesitnig kasilgaasi gkglggmlfs
      721 rfgrssttqs setskdsmed ekkpvaspsa ttvgtqtlph sssgfldsay frlqesffnl
      781 pqllfpenvm qnkdnalvel dhridfelre glvesrywsa vtshtaywss ldvalflltf
      841 mykhehddda kpnldpi
//
LOCUS       XP_016877158             829 aa            linear   PRI 05-AUG-2025
DEFINITION  phospholipase DDHD1 isoform X7 [Homo sapiens].
ACCESSION   XP_016877158
VERSION     XP_016877158.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021669.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..829
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..829
                     /product="phospholipase DDHD1 isoform X7"
                     /calculated_mol_wt=92014
     Region          568..814
                     /region_name="DDHD"
                     /note="DDHD domain; pfam02862"
                     /db_xref="CDD:460725"
     CDS             1..829
                     /gene="DDHD1"
                     /gene_synonym="iPLA1alpha; iPLA1I; PA-PLA1; PAPLA1; SPG28"
                     /coded_by="XM_017021669.2:226..2715"
                     /db_xref="GeneID:80821"
                     /db_xref="HGNC:HGNC:19714"
                     /db_xref="MIM:614603"
ORIGIN      
        1 mnypgrgspr spehngrggg ggawelgsda rpafgggvcc fehlpggdpd dgdvplallr
       61 gepglhlapg tddhnhhlal dpclsdenyd fssaesgssl ryysegesgg ggsslslhpp
      121 qqpplvptns ggggatggsp gerkrtrlgg paarhryevv telgpeevrw fykedkktwk
      181 pfigydslri elafrtllqt tgarpqggdr dgdhvcsptg passsgeddd edracgfcqs
      241 ttghepemve lvniepvcvr gglyevdvtq gecypvywnq adkipvmrgq wfidgtwqpl
      301 eeeesnlieq ehlncfrgqq mqenfdievs ksidgkdass sgtrlhrgyv eeatledkps
      361 qtthivfvvh gigqkmdqgr iikntammre aarkieerhf snhathvefl pvewrskltl
      421 dgdtvdsitp dkvrglrdml nssamdimyy tsplyrdelv kglqqelnrl yslfcsrnpd
      481 feekggkvsi vshslgcvit ydimtgwnpv rlyeqllqke eelpderwms yeerhlldel
      541 yitkrrlkei eerlhglkas smtqtpalkf kvenffcmgs plavflalrg irpgntgsqd
      601 hilpreicnr llnifhptdp vayrleplil khysnispvq ihwyntsnpl pyehmkpsfl
      661 npakeptsvs enegistips pvtspvlsrr hygesitnig kasilgaasi gkglggmlfs
      721 rfgrssttqs setskdsmed ekkpvaspsa ttvgtqtlph sssgfldsal eldhridfel
      781 reglvesryw savtshtayw ssldvalfll tfmykhehdd dakpnldpi
//
LOCUS       XP_011535499             375 aa            linear   PRI 05-AUG-2025
DEFINITION  G-protein coupled receptor 68 isoform X1 [Homo sapiens].
ACCESSION   XP_011535499
VERSION     XP_011535499.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537197.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..375
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..375
                     /product="G-protein coupled receptor 68 isoform X1"
                     /calculated_mol_wt=41957
     Region          32..307
                     /region_name="7tmA_GPR68_OGR1"
                     /note="G protein-coupled receptor 68, member of the class
                     A family of seven-transmembrane G protein-coupled
                     receptors; cd15367"
                     /db_xref="CDD:320489"
     Region          32..59
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:320489"
     Region          66..91
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320489"
     Site            order(87,90..91,104..109,111..112,115,160,162..166,192,
                     195..197,199..201,203..204,251,254..255,257..258,261,
                     274..275,277..279,282,285..286)
                     /site_type="other"
                     /note="putative ligand binding pocket [chemical binding]"
                     /db_xref="CDD:320489"
     Region          104..134
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320489"
     Region          146..168
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320489"
     Region          192..221
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320489"
     Region          231..261
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320489"
     Region          275..300
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320489"
     CDS             1..375
                     /gene="GPR68"
                     /gene_synonym="AI2A6; GPR12A; OGR1"
                     /coded_by="XM_011537197.4:609..1736"
                     /db_xref="GeneID:8111"
                     /db_xref="HGNC:HGNC:4519"
                     /db_xref="MIM:601404"
ORIGIN      
        1 mrsvapsgpk mgnitadnss msctidhtih qtlapvvyvt vlvvgfpanc lslyfgylqi
       61 karnelgvyl cnltvadlfy icslpfwlqy vlqhdnwshg dlscqvcgil lyeniyisvg
      121 flccisvdry lavahpfrfh qfrtlkaavg vsvviwakel ltsiyflmhe eviedenqhr
      181 vcfehypiqa wqrainyyrf lvgflfpicl llasyqgilr avrrshgtqk srkdqiqrlv
      241 lstvviflac flpyhvlllv rsvweascdf akgvfnayhf sllltsfncv adpvlycfvs
      301 etthrdlarl rgaclafltc srtgrareay plgapeasgk sgaqgeepel ltklhpafqt
      361 pnspgsggfp tgrla
//
LOCUS       XP_047287746             375 aa            linear   PRI 05-AUG-2025
DEFINITION  G-protein coupled receptor 68 isoform X1 [Homo sapiens].
ACCESSION   XP_047287746
VERSION     XP_047287746.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431790.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..375
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..375
                     /product="G-protein coupled receptor 68 isoform X1"
                     /calculated_mol_wt=41957
     Region          32..307
                     /region_name="7tmA_GPR68_OGR1"
                     /note="G protein-coupled receptor 68, member of the class
                     A family of seven-transmembrane G protein-coupled
                     receptors; cd15367"
                     /db_xref="CDD:320489"
     Region          32..59
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:320489"
     Region          66..91
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320489"
     Site            order(87,90..91,104..109,111..112,115,160,162..166,192,
                     195..197,199..201,203..204,251,254..255,257..258,261,
                     274..275,277..279,282,285..286)
                     /site_type="other"
                     /note="putative ligand binding pocket [chemical binding]"
                     /db_xref="CDD:320489"
     Region          104..134
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320489"
     Region          146..168
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320489"
     Region          192..221
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320489"
     Region          231..261
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320489"
     Region          275..300
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320489"
     CDS             1..375
                     /gene="GPR68"
                     /gene_synonym="AI2A6; GPR12A; OGR1"
                     /coded_by="XM_047431790.1:5395..6522"
                     /db_xref="GeneID:8111"
                     /db_xref="HGNC:HGNC:4519"
                     /db_xref="MIM:601404"
ORIGIN      
        1 mrsvapsgpk mgnitadnss msctidhtih qtlapvvyvt vlvvgfpanc lslyfgylqi
       61 karnelgvyl cnltvadlfy icslpfwlqy vlqhdnwshg dlscqvcgil lyeniyisvg
      121 flccisvdry lavahpfrfh qfrtlkaavg vsvviwakel ltsiyflmhe eviedenqhr
      181 vcfehypiqa wqrainyyrf lvgflfpicl llasyqgilr avrrshgtqk srkdqiqrlv
      241 lstvviflac flpyhvlllv rsvweascdf akgvfnayhf sllltsfncv adpvlycfvs
      301 etthrdlarl rgaclafltc srtgrareay plgapeasgk sgaqgeepel ltklhpafqt
      361 pnspgsggfp tgrla
//
LOCUS       XP_047287747             375 aa            linear   PRI 05-AUG-2025
DEFINITION  G-protein coupled receptor 68 isoform X1 [Homo sapiens].
ACCESSION   XP_047287747
VERSION     XP_047287747.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431791.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..375
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..375
                     /product="G-protein coupled receptor 68 isoform X1"
                     /calculated_mol_wt=41957
     Region          32..307
                     /region_name="7tmA_GPR68_OGR1"
                     /note="G protein-coupled receptor 68, member of the class
                     A family of seven-transmembrane G protein-coupled
                     receptors; cd15367"
                     /db_xref="CDD:320489"
     Region          32..59
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:320489"
     Region          66..91
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320489"
     Site            order(87,90..91,104..109,111..112,115,160,162..166,192,
                     195..197,199..201,203..204,251,254..255,257..258,261,
                     274..275,277..279,282,285..286)
                     /site_type="other"
                     /note="putative ligand binding pocket [chemical binding]"
                     /db_xref="CDD:320489"
     Region          104..134
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320489"
     Region          146..168
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320489"
     Region          192..221
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320489"
     Region          231..261
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320489"
     Region          275..300
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320489"
     CDS             1..375
                     /gene="GPR68"
                     /gene_synonym="AI2A6; GPR12A; OGR1"
                     /coded_by="XM_047431791.1:5570..6697"
                     /db_xref="GeneID:8111"
                     /db_xref="HGNC:HGNC:4519"
                     /db_xref="MIM:601404"
ORIGIN      
        1 mrsvapsgpk mgnitadnss msctidhtih qtlapvvyvt vlvvgfpanc lslyfgylqi
       61 karnelgvyl cnltvadlfy icslpfwlqy vlqhdnwshg dlscqvcgil lyeniyisvg
      121 flccisvdry lavahpfrfh qfrtlkaavg vsvviwakel ltsiyflmhe eviedenqhr
      181 vcfehypiqa wqrainyyrf lvgflfpicl llasyqgilr avrrshgtqk srkdqiqrlv
      241 lstvviflac flpyhvlllv rsvweascdf akgvfnayhf sllltsfncv adpvlycfvs
      301 etthrdlarl rgaclafltc srtgrareay plgapeasgk sgaqgeepel ltklhpafqt
      361 pnspgsggfp tgrla
//
LOCUS       XP_011535500             375 aa            linear   PRI 05-AUG-2025
DEFINITION  G-protein coupled receptor 68 isoform X1 [Homo sapiens].
ACCESSION   XP_011535500
VERSION     XP_011535500.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537198.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..375
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..375
                     /product="G-protein coupled receptor 68 isoform X1"
                     /calculated_mol_wt=41957
     Region          32..307
                     /region_name="7tmA_GPR68_OGR1"
                     /note="G protein-coupled receptor 68, member of the class
                     A family of seven-transmembrane G protein-coupled
                     receptors; cd15367"
                     /db_xref="CDD:320489"
     Region          32..59
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:320489"
     Region          66..91
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320489"
     Site            order(87,90..91,104..109,111..112,115,160,162..166,192,
                     195..197,199..201,203..204,251,254..255,257..258,261,
                     274..275,277..279,282,285..286)
                     /site_type="other"
                     /note="putative ligand binding pocket [chemical binding]"
                     /db_xref="CDD:320489"
     Region          104..134
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320489"
     Region          146..168
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320489"
     Region          192..221
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320489"
     Region          231..261
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320489"
     Region          275..300
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320489"
     CDS             1..375
                     /gene="GPR68"
                     /gene_synonym="AI2A6; GPR12A; OGR1"
                     /coded_by="XM_011537198.3:403..1530"
                     /db_xref="GeneID:8111"
                     /db_xref="HGNC:HGNC:4519"
                     /db_xref="MIM:601404"
ORIGIN      
        1 mrsvapsgpk mgnitadnss msctidhtih qtlapvvyvt vlvvgfpanc lslyfgylqi
       61 karnelgvyl cnltvadlfy icslpfwlqy vlqhdnwshg dlscqvcgil lyeniyisvg
      121 flccisvdry lavahpfrfh qfrtlkaavg vsvviwakel ltsiyflmhe eviedenqhr
      181 vcfehypiqa wqrainyyrf lvgflfpicl llasyqgilr avrrshgtqk srkdqiqrlv
      241 lstvviflac flpyhvlllv rsvweascdf akgvfnayhf sllltsfncv adpvlycfvs
      301 etthrdlarl rgaclafltc srtgrareay plgapeasgk sgaqgeepel ltklhpafqt
      361 pnspgsggfp tgrla
//
LOCUS       XP_011535501             375 aa            linear   PRI 05-AUG-2025
DEFINITION  G-protein coupled receptor 68 isoform X1 [Homo sapiens].
ACCESSION   XP_011535501
VERSION     XP_011535501.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537199.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..375
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..375
                     /product="G-protein coupled receptor 68 isoform X1"
                     /calculated_mol_wt=41957
     Region          32..307
                     /region_name="7tmA_GPR68_OGR1"
                     /note="G protein-coupled receptor 68, member of the class
                     A family of seven-transmembrane G protein-coupled
                     receptors; cd15367"
                     /db_xref="CDD:320489"
     Region          32..59
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:320489"
     Region          66..91
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320489"
     Site            order(87,90..91,104..109,111..112,115,160,162..166,192,
                     195..197,199..201,203..204,251,254..255,257..258,261,
                     274..275,277..279,282,285..286)
                     /site_type="other"
                     /note="putative ligand binding pocket [chemical binding]"
                     /db_xref="CDD:320489"
     Region          104..134
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320489"
     Region          146..168
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320489"
     Region          192..221
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320489"
     Region          231..261
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320489"
     Region          275..300
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320489"
     CDS             1..375
                     /gene="GPR68"
                     /gene_synonym="AI2A6; GPR12A; OGR1"
                     /coded_by="XM_011537199.3:261..1388"
                     /db_xref="GeneID:8111"
                     /db_xref="HGNC:HGNC:4519"
                     /db_xref="MIM:601404"
ORIGIN      
        1 mrsvapsgpk mgnitadnss msctidhtih qtlapvvyvt vlvvgfpanc lslyfgylqi
       61 karnelgvyl cnltvadlfy icslpfwlqy vlqhdnwshg dlscqvcgil lyeniyisvg
      121 flccisvdry lavahpfrfh qfrtlkaavg vsvviwakel ltsiyflmhe eviedenqhr
      181 vcfehypiqa wqrainyyrf lvgflfpicl llasyqgilr avrrshgtqk srkdqiqrlv
      241 lstvviflac flpyhvlllv rsvweascdf akgvfnayhf sllltsfncv adpvlycfvs
      301 etthrdlarl rgaclafltc srtgrareay plgapeasgk sgaqgeepel ltklhpafqt
      361 pnspgsggfp tgrla
//
LOCUS       XP_047287748             375 aa            linear   PRI 05-AUG-2025
DEFINITION  G-protein coupled receptor 68 isoform X1 [Homo sapiens].
ACCESSION   XP_047287748
VERSION     XP_047287748.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431792.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..375
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..375
                     /product="G-protein coupled receptor 68 isoform X1"
                     /calculated_mol_wt=41957
     Region          32..307
                     /region_name="7tmA_GPR68_OGR1"
                     /note="G protein-coupled receptor 68, member of the class
                     A family of seven-transmembrane G protein-coupled
                     receptors; cd15367"
                     /db_xref="CDD:320489"
     Region          32..59
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:320489"
     Region          66..91
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320489"
     Site            order(87,90..91,104..109,111..112,115,160,162..166,192,
                     195..197,199..201,203..204,251,254..255,257..258,261,
                     274..275,277..279,282,285..286)
                     /site_type="other"
                     /note="putative ligand binding pocket [chemical binding]"
                     /db_xref="CDD:320489"
     Region          104..134
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320489"
     Region          146..168
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320489"
     Region          192..221
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320489"
     Region          231..261
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320489"
     Region          275..300
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320489"
     CDS             1..375
                     /gene="GPR68"
                     /gene_synonym="AI2A6; GPR12A; OGR1"
                     /coded_by="XM_047431792.1:117..1244"
                     /db_xref="GeneID:8111"
                     /db_xref="HGNC:HGNC:4519"
                     /db_xref="MIM:601404"
ORIGIN      
        1 mrsvapsgpk mgnitadnss msctidhtih qtlapvvyvt vlvvgfpanc lslyfgylqi
       61 karnelgvyl cnltvadlfy icslpfwlqy vlqhdnwshg dlscqvcgil lyeniyisvg
      121 flccisvdry lavahpfrfh qfrtlkaavg vsvviwakel ltsiyflmhe eviedenqhr
      181 vcfehypiqa wqrainyyrf lvgflfpicl llasyqgilr avrrshgtqk srkdqiqrlv
      241 lstvviflac flpyhvlllv rsvweascdf akgvfnayhf sllltsfncv adpvlycfvs
      301 etthrdlarl rgaclafltc srtgrareay plgapeasgk sgaqgeepel ltklhpafqt
      361 pnspgsggfp tgrla
//
LOCUS       XP_011535505             399 aa            linear   PRI 05-AUG-2025
DEFINITION  protein amnionless isoform X1 [Homo sapiens].
ACCESSION   XP_011535505
VERSION     XP_011535505.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537203.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..399
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..399
                     /product="protein amnionless isoform X1"
                     /calculated_mol_wt=41782
     Region          1..393
                     /region_name="Amnionless"
                     /note="pfam14828"
                     /db_xref="CDD:464340"
     CDS             1..399
                     /gene="AMN"
                     /gene_synonym="amnionless; IGS2; PRO1028"
                     /coded_by="XM_011537203.4:581..1780"
                     /db_xref="GeneID:81693"
                     /db_xref="HGNC:HGNC:14604"
                     /db_xref="MIM:605799"
ORIGIN      
        1 mvsvlvqegh avsdmllpld gelvlasgag fgvsdvgshl dcgagepavf rdsdrfswhd
       61 phlwrsgdea pglffvdaer vpcrhddvff ppsasfrvgl gpgaspvrvr sisalgrtft
      121 rdedlavfla sragrlrfhg pgalsvgped cadpsgcvcg naeaqpwica allqplggrc
      181 pqaachsalr pqgqccdlcg avvllthgpa fdleryrari ldtflglpqy hglqvavskv
      241 prssrlread teiqvvlven gpetggagrl aralladvae ngealgvlea tmresgahvw
      301 gssaaglagg vaaavllall vllvappllr ragrlrwrrh eaaapagapl gfrnpvfdvt
      361 aseelplprr lslvpkaaad stshsyfvnp lfagaeaea
//
LOCUS       XP_024305483             151 aa            linear   PRI 05-AUG-2025
DEFINITION  dynein axonemal light chain 1 isoform X1 [Homo sapiens].
ACCESSION   XP_024305483
VERSION     XP_024305483.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449715.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..151
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..151
                     /product="dynein axonemal light chain 1 isoform X1"
                     /calculated_mol_wt=16965
     Region          5..142
                     /region_name="PPP1R42"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     cl42388"
                     /db_xref="CDD:455733"
     Region          11..32
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          33..51
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          56..77
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275382"
     Region          78..101
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275382"
     Region          103..133
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275382"
     CDS             1..151
                     /gene="DNAL1"
                     /gene_synonym="C14orf168; CILD16; LC1"
                     /coded_by="XM_024449715.2:275..730"
                     /db_xref="GeneID:83544"
                     /db_xref="HGNC:HGNC:23247"
                     /db_xref="MIM:610062"
ORIGIN      
        1 mdaslsmlan ceklslstnc iekianlngl knlrilslgr nniknlngle avgdtleelw
       61 isynfieklk gihimkklki lymsnnlvkd waefvklael pcledlvfvg npleekhsae
      121 nnwieeatkr vpklkkldgt pvikgdeeed n
//
LOCUS       XP_016877168             151 aa            linear   PRI 05-AUG-2025
DEFINITION  dynein axonemal light chain 1 isoform X1 [Homo sapiens].
ACCESSION   XP_016877168
VERSION     XP_016877168.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021679.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..151
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..151
                     /product="dynein axonemal light chain 1 isoform X1"
                     /calculated_mol_wt=16965
     Region          5..142
                     /region_name="PPP1R42"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     cl42388"
                     /db_xref="CDD:455733"
     Region          11..32
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          33..51
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          56..77
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275382"
     Region          78..101
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275382"
     Region          103..133
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275382"
     CDS             1..151
                     /gene="DNAL1"
                     /gene_synonym="C14orf168; CILD16; LC1"
                     /coded_by="XM_017021679.3:317..772"
                     /db_xref="GeneID:83544"
                     /db_xref="HGNC:HGNC:23247"
                     /db_xref="MIM:610062"
ORIGIN      
        1 mdaslsmlan ceklslstnc iekianlngl knlrilslgr nniknlngle avgdtleelw
       61 isynfieklk gihimkklki lymsnnlvkd waefvklael pcledlvfvg npleekhsae
      121 nnwieeatkr vpklkkldgt pvikgdeeed n
//
LOCUS       XP_016877169             603 aa            linear   PRI 05-AUG-2025
DEFINITION  ribosomal protein S6 kinase-like 1 isoform X1 [Homo sapiens].
ACCESSION   XP_016877169
VERSION     XP_016877169.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021680.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..603
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..603
                     /product="ribosomal protein S6 kinase-like 1 isoform X1"
                     /calculated_mol_wt=65850
     Region          48..122
                     /region_name="MIT_SNX15"
                     /note="MIT: domain contained within Microtubule
                     Interacting and Trafficking molecules. This MIT domain
                     sub-family is found in sorting nexin 15 and related
                     proteins. The molecular function of the MIT domain is
                     unclear; cd02677"
                     /db_xref="CDD:239140"
     Region          148..555
                     /region_name="STKc_RPK118_like"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     RPK118, and similar proteins; cd05576"
                     /db_xref="CDD:270728"
     Site            order(154..158,178,191,193,217,233..234,236,240,242,428,
                     430,432..433,435,445..446,449,460..465,492,498,501)
                     /site_type="active"
                     /db_xref="CDD:270728"
     Site            order(154..158,178,191,193,217,234..236,240,428,430,
                     432..433,435,445..446)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270728"
     Site            order(158,240,242,428,430,432,449,460..465,492,498,501)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270728"
     Site            445..465
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270728"
     CDS             1..603
                     /gene="RPS6KL1"
                     /gene_synonym="RSKL2"
                     /coded_by="XM_017021680.3:610..2421"
                     /db_xref="GeneID:83694"
                     /db_xref="HGNC:HGNC:20222"
ORIGIN      
        1 mslvaceclp spglepepcs rarsqahvyl eqirnrvalg vpdmtkrdyl vdaatqirla
       61 lerdvsedye aafnhyqngv dvllrgihvd pnkerreavk lkitkylrra eeifnchlqr
      121 plssgaspsa gfsslrlrpi rtlssaveql rgcrvvgvie krdlavlprl vsnslpqvql
      181 vqdpatggtf vvkslprchm vsrerltiip hgvpymtkll ryfvsedsif lhlehvqggt
      241 lwshllsqah srhsglssgs tqermkaqln phlnlltpar lpsghapgqd rialepprts
      301 pnlllageap strpqreaeg eptartstsg ssdlpkapgg hlhlqarrag qnsdagpprg
      361 ltwvpegagp vlggcgrgmd qsclsadgag rgcgratwsv reeqvkqwaa emlvalealh
      421 eqgvlcrdlh pgnllldqag hirltyfgqw sevepqccge avdnlysape vggiseltea
      481 cdwwsfgsll yelltgmals qshpsgiqah tqlqlpewls rpaaslltel lqfeptrrlg
      541 mgeggvsklk shpffstiqw sklvgalvll sgthfppvtd lhrgmaslqe lsrqglwkrq
      601 gcv
//
LOCUS       XP_011535509             603 aa            linear   PRI 05-AUG-2025
DEFINITION  ribosomal protein S6 kinase-like 1 isoform X1 [Homo sapiens].
ACCESSION   XP_011535509
VERSION     XP_011535509.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537207.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..603
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..603
                     /product="ribosomal protein S6 kinase-like 1 isoform X1"
                     /calculated_mol_wt=65850
     Region          48..122
                     /region_name="MIT_SNX15"
                     /note="MIT: domain contained within Microtubule
                     Interacting and Trafficking molecules. This MIT domain
                     sub-family is found in sorting nexin 15 and related
                     proteins. The molecular function of the MIT domain is
                     unclear; cd02677"
                     /db_xref="CDD:239140"
     Region          148..555
                     /region_name="STKc_RPK118_like"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     RPK118, and similar proteins; cd05576"
                     /db_xref="CDD:270728"
     Site            order(154..158,178,191,193,217,233..234,236,240,242,428,
                     430,432..433,435,445..446,449,460..465,492,498,501)
                     /site_type="active"
                     /db_xref="CDD:270728"
     Site            order(154..158,178,191,193,217,234..236,240,428,430,
                     432..433,435,445..446)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270728"
     Site            order(158,240,242,428,430,432,449,460..465,492,498,501)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270728"
     Site            445..465
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270728"
     CDS             1..603
                     /gene="RPS6KL1"
                     /gene_synonym="RSKL2"
                     /coded_by="XM_011537207.3:927..2738"
                     /db_xref="GeneID:83694"
                     /db_xref="HGNC:HGNC:20222"
ORIGIN      
        1 mslvaceclp spglepepcs rarsqahvyl eqirnrvalg vpdmtkrdyl vdaatqirla
       61 lerdvsedye aafnhyqngv dvllrgihvd pnkerreavk lkitkylrra eeifnchlqr
      121 plssgaspsa gfsslrlrpi rtlssaveql rgcrvvgvie krdlavlprl vsnslpqvql
      181 vqdpatggtf vvkslprchm vsrerltiip hgvpymtkll ryfvsedsif lhlehvqggt
      241 lwshllsqah srhsglssgs tqermkaqln phlnlltpar lpsghapgqd rialepprts
      301 pnlllageap strpqreaeg eptartstsg ssdlpkapgg hlhlqarrag qnsdagpprg
      361 ltwvpegagp vlggcgrgmd qsclsadgag rgcgratwsv reeqvkqwaa emlvalealh
      421 eqgvlcrdlh pgnllldqag hirltyfgqw sevepqccge avdnlysape vggiseltea
      481 cdwwsfgsll yelltgmals qshpsgiqah tqlqlpewls rpaaslltel lqfeptrrlg
      541 mgeggvsklk shpffstiqw sklvgalvll sgthfppvtd lhrgmaslqe lsrqglwkrq
      601 gcv
//
LOCUS       XP_011535508             603 aa            linear   PRI 05-AUG-2025
DEFINITION  ribosomal protein S6 kinase-like 1 isoform X1 [Homo sapiens].
ACCESSION   XP_011535508
VERSION     XP_011535508.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537206.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..603
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..603
                     /product="ribosomal protein S6 kinase-like 1 isoform X1"
                     /calculated_mol_wt=65850
     Region          48..122
                     /region_name="MIT_SNX15"
                     /note="MIT: domain contained within Microtubule
                     Interacting and Trafficking molecules. This MIT domain
                     sub-family is found in sorting nexin 15 and related
                     proteins. The molecular function of the MIT domain is
                     unclear; cd02677"
                     /db_xref="CDD:239140"
     Region          148..555
                     /region_name="STKc_RPK118_like"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     RPK118, and similar proteins; cd05576"
                     /db_xref="CDD:270728"
     Site            order(154..158,178,191,193,217,233..234,236,240,242,428,
                     430,432..433,435,445..446,449,460..465,492,498,501)
                     /site_type="active"
                     /db_xref="CDD:270728"
     Site            order(154..158,178,191,193,217,234..236,240,428,430,
                     432..433,435,445..446)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270728"
     Site            order(158,240,242,428,430,432,449,460..465,492,498,501)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270728"
     Site            445..465
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270728"
     CDS             1..603
                     /gene="RPS6KL1"
                     /gene_synonym="RSKL2"
                     /coded_by="XM_011537206.4:578..2389"
                     /db_xref="GeneID:83694"
                     /db_xref="HGNC:HGNC:20222"
ORIGIN      
        1 mslvaceclp spglepepcs rarsqahvyl eqirnrvalg vpdmtkrdyl vdaatqirla
       61 lerdvsedye aafnhyqngv dvllrgihvd pnkerreavk lkitkylrra eeifnchlqr
      121 plssgaspsa gfsslrlrpi rtlssaveql rgcrvvgvie krdlavlprl vsnslpqvql
      181 vqdpatggtf vvkslprchm vsrerltiip hgvpymtkll ryfvsedsif lhlehvqggt
      241 lwshllsqah srhsglssgs tqermkaqln phlnlltpar lpsghapgqd rialepprts
      301 pnlllageap strpqreaeg eptartstsg ssdlpkapgg hlhlqarrag qnsdagpprg
      361 ltwvpegagp vlggcgrgmd qsclsadgag rgcgratwsv reeqvkqwaa emlvalealh
      421 eqgvlcrdlh pgnllldqag hirltyfgqw sevepqccge avdnlysape vggiseltea
      481 cdwwsfgsll yelltgmals qshpsgiqah tqlqlpewls rpaaslltel lqfeptrrlg
      541 mgeggvsklk shpffstiqw sklvgalvll sgthfppvtd lhrgmaslqe lsrqglwkrq
      601 gcv
//
LOCUS       XP_024305484             587 aa            linear   PRI 05-AUG-2025
DEFINITION  ribosomal protein S6 kinase-like 1 isoform X2 [Homo sapiens].
ACCESSION   XP_024305484
VERSION     XP_024305484.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449716.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..587
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..587
                     /product="ribosomal protein S6 kinase-like 1 isoform X2"
                     /calculated_mol_wt=64090
     Region          48..122
                     /region_name="MIT_SNX15"
                     /note="MIT: domain contained within Microtubule
                     Interacting and Trafficking molecules. This MIT domain
                     sub-family is found in sorting nexin 15 and related
                     proteins. The molecular function of the MIT domain is
                     unclear; cd02677"
                     /db_xref="CDD:239140"
     Region          148..539
                     /region_name="STKc_RPK118_like"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     RPK118, and similar proteins; cd05576"
                     /db_xref="CDD:270728"
     Site            order(154..158,162,175,177,201,217..218,220,224,226,412,
                     414,416..417,419,429..430,433,444..449,476,482,485)
                     /site_type="active"
                     /db_xref="CDD:270728"
     Site            order(154..158,162,175,177,201,218..220,224,412,414,
                     416..417,419,429..430)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270728"
     Site            order(158,224,226,412,414,416,433,444..449,476,482,485)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270728"
     Site            429..449
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270728"
     CDS             1..587
                     /gene="RPS6KL1"
                     /gene_synonym="RSKL2"
                     /coded_by="XM_024449716.2:610..2373"
                     /db_xref="GeneID:83694"
                     /db_xref="HGNC:HGNC:20222"
ORIGIN      
        1 mslvaceclp spglepepcs rarsqahvyl eqirnrvalg vpdmtkrdyl vdaatqirla
       61 lerdvsedye aafnhyqngv dvllrgihvd pnkerreavk lkitkylrra eeifnchlqr
      121 plssgaspsa gfsslrlrpi rtlssaveql rgcrvvgvie kvqlvqdpat ggtfvvkslp
      181 rchmvsrerl tiiphgvpym tkllryfvse dsiflhlehv qggtlwshll sqahsrhsgl
      241 ssgstqermk aqlnphlnll tparlpsgha pgqdrialep prtspnllla geapstrpqr
      301 eaegeptart stsgssdlpk apgghlhlqa rragqnsdag pprgltwvpe gagpvlggcg
      361 rgmdqsclsa dgagrgcgra twsvreeqvk qwaaemlval ealheqgvlc rdlhpgnlll
      421 dqaghirlty fgqwsevepq ccgeavdnly sapevggise lteacdwwsf gsllyelltg
      481 malsqshpsg iqahtqlqlp ewlsrpaasl ltellqfept rrlgmgeggv sklkshpffs
      541 tiqwsklvga lvllsgthfp pvtdlhrgma slqelsrqgl wkrqgcv
//
LOCUS       XP_024305485             587 aa            linear   PRI 05-AUG-2025
DEFINITION  ribosomal protein S6 kinase-like 1 isoform X2 [Homo sapiens].
ACCESSION   XP_024305485
VERSION     XP_024305485.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449717.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..587
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..587
                     /product="ribosomal protein S6 kinase-like 1 isoform X2"
                     /calculated_mol_wt=64090
     Region          48..122
                     /region_name="MIT_SNX15"
                     /note="MIT: domain contained within Microtubule
                     Interacting and Trafficking molecules. This MIT domain
                     sub-family is found in sorting nexin 15 and related
                     proteins. The molecular function of the MIT domain is
                     unclear; cd02677"
                     /db_xref="CDD:239140"
     Region          148..539
                     /region_name="STKc_RPK118_like"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     RPK118, and similar proteins; cd05576"
                     /db_xref="CDD:270728"
     Site            order(154..158,162,175,177,201,217..218,220,224,226,412,
                     414,416..417,419,429..430,433,444..449,476,482,485)
                     /site_type="active"
                     /db_xref="CDD:270728"
     Site            order(154..158,162,175,177,201,218..220,224,412,414,
                     416..417,419,429..430)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270728"
     Site            order(158,224,226,412,414,416,433,444..449,476,482,485)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270728"
     Site            429..449
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270728"
     CDS             1..587
                     /gene="RPS6KL1"
                     /gene_synonym="RSKL2"
                     /coded_by="XM_024449717.2:578..2341"
                     /db_xref="GeneID:83694"
                     /db_xref="HGNC:HGNC:20222"
ORIGIN      
        1 mslvaceclp spglepepcs rarsqahvyl eqirnrvalg vpdmtkrdyl vdaatqirla
       61 lerdvsedye aafnhyqngv dvllrgihvd pnkerreavk lkitkylrra eeifnchlqr
      121 plssgaspsa gfsslrlrpi rtlssaveql rgcrvvgvie kvqlvqdpat ggtfvvkslp
      181 rchmvsrerl tiiphgvpym tkllryfvse dsiflhlehv qggtlwshll sqahsrhsgl
      241 ssgstqermk aqlnphlnll tparlpsgha pgqdrialep prtspnllla geapstrpqr
      301 eaegeptart stsgssdlpk apgghlhlqa rragqnsdag pprgltwvpe gagpvlggcg
      361 rgmdqsclsa dgagrgcgra twsvreeqvk qwaaemlval ealheqgvlc rdlhpgnlll
      421 dqaghirlty fgqwsevepq ccgeavdnly sapevggise lteacdwwsf gsllyelltg
      481 malsqshpsg iqahtqlqlp ewlsrpaasl ltellqfept rrlgmgeggv sklkshpffs
      541 tiqwsklvga lvllsgthfp pvtdlhrgma slqelsrqgl wkrqgcv
//
LOCUS       XP_016877171             587 aa            linear   PRI 05-AUG-2025
DEFINITION  ribosomal protein S6 kinase-like 1 isoform X2 [Homo sapiens].
ACCESSION   XP_016877171
VERSION     XP_016877171.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021682.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..587
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..587
                     /product="ribosomal protein S6 kinase-like 1 isoform X2"
                     /calculated_mol_wt=64090
     Region          48..122
                     /region_name="MIT_SNX15"
                     /note="MIT: domain contained within Microtubule
                     Interacting and Trafficking molecules. This MIT domain
                     sub-family is found in sorting nexin 15 and related
                     proteins. The molecular function of the MIT domain is
                     unclear; cd02677"
                     /db_xref="CDD:239140"
     Region          148..539
                     /region_name="STKc_RPK118_like"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     RPK118, and similar proteins; cd05576"
                     /db_xref="CDD:270728"
     Site            order(154..158,162,175,177,201,217..218,220,224,226,412,
                     414,416..417,419,429..430,433,444..449,476,482,485)
                     /site_type="active"
                     /db_xref="CDD:270728"
     Site            order(154..158,162,175,177,201,218..220,224,412,414,
                     416..417,419,429..430)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270728"
     Site            order(158,224,226,412,414,416,433,444..449,476,482,485)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270728"
     Site            429..449
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270728"
     CDS             1..587
                     /gene="RPS6KL1"
                     /gene_synonym="RSKL2"
                     /coded_by="XM_017021682.2:102..1865"
                     /db_xref="GeneID:83694"
                     /db_xref="HGNC:HGNC:20222"
ORIGIN      
        1 mslvaceclp spglepepcs rarsqahvyl eqirnrvalg vpdmtkrdyl vdaatqirla
       61 lerdvsedye aafnhyqngv dvllrgihvd pnkerreavk lkitkylrra eeifnchlqr
      121 plssgaspsa gfsslrlrpi rtlssaveql rgcrvvgvie kvqlvqdpat ggtfvvkslp
      181 rchmvsrerl tiiphgvpym tkllryfvse dsiflhlehv qggtlwshll sqahsrhsgl
      241 ssgstqermk aqlnphlnll tparlpsgha pgqdrialep prtspnllla geapstrpqr
      301 eaegeptart stsgssdlpk apgghlhlqa rragqnsdag pprgltwvpe gagpvlggcg
      361 rgmdqsclsa dgagrgcgra twsvreeqvk qwaaemlval ealheqgvlc rdlhpgnlll
      421 dqaghirlty fgqwsevepq ccgeavdnly sapevggise lteacdwwsf gsllyelltg
      481 malsqshpsg iqahtqlqlp ewlsrpaasl ltellqfept rrlgmgeggv sklkshpffs
      541 tiqwsklvga lvllsgthfp pvtdlhrgma slqelsrqgl wkrqgcv
//
LOCUS       XP_047287752             587 aa            linear   PRI 05-AUG-2025
DEFINITION  ribosomal protein S6 kinase-like 1 isoform X2 [Homo sapiens].
ACCESSION   XP_047287752
VERSION     XP_047287752.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431796.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..587
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..587
                     /product="ribosomal protein S6 kinase-like 1 isoform X2"
                     /calculated_mol_wt=64090
     Region          48..122
                     /region_name="MIT_SNX15"
                     /note="MIT: domain contained within Microtubule
                     Interacting and Trafficking molecules. This MIT domain
                     sub-family is found in sorting nexin 15 and related
                     proteins. The molecular function of the MIT domain is
                     unclear; cd02677"
                     /db_xref="CDD:239140"
     Region          148..539
                     /region_name="STKc_RPK118_like"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     RPK118, and similar proteins; cd05576"
                     /db_xref="CDD:270728"
     Site            order(154..158,162,175,177,201,217..218,220,224,226,412,
                     414,416..417,419,429..430,433,444..449,476,482,485)
                     /site_type="active"
                     /db_xref="CDD:270728"
     Site            order(154..158,162,175,177,201,218..220,224,412,414,
                     416..417,419,429..430)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270728"
     Site            order(158,224,226,412,414,416,433,444..449,476,482,485)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270728"
     Site            429..449
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270728"
     CDS             1..587
                     /gene="RPS6KL1"
                     /gene_synonym="RSKL2"
                     /coded_by="XM_047431796.1:567..2330"
                     /db_xref="GeneID:83694"
                     /db_xref="HGNC:HGNC:20222"
ORIGIN      
        1 mslvaceclp spglepepcs rarsqahvyl eqirnrvalg vpdmtkrdyl vdaatqirla
       61 lerdvsedye aafnhyqngv dvllrgihvd pnkerreavk lkitkylrra eeifnchlqr
      121 plssgaspsa gfsslrlrpi rtlssaveql rgcrvvgvie kvqlvqdpat ggtfvvkslp
      181 rchmvsrerl tiiphgvpym tkllryfvse dsiflhlehv qggtlwshll sqahsrhsgl
      241 ssgstqermk aqlnphlnll tparlpsgha pgqdrialep prtspnllla geapstrpqr
      301 eaegeptart stsgssdlpk apgghlhlqa rragqnsdag pprgltwvpe gagpvlggcg
      361 rgmdqsclsa dgagrgcgra twsvreeqvk qwaaemlval ealheqgvlc rdlhpgnlll
      421 dqaghirlty fgqwsevepq ccgeavdnly sapevggise lteacdwwsf gsllyelltg
      481 malsqshpsg iqahtqlqlp ewlsrpaasl ltellqfept rrlgmgeggv sklkshpffs
      541 tiqwsklvga lvllsgthfp pvtdlhrgma slqelsrqgl wkrqgcv
//
LOCUS       XP_016877172             573 aa            linear   PRI 05-AUG-2025
DEFINITION  ribosomal protein S6 kinase-like 1 isoform X3 [Homo sapiens].
ACCESSION   XP_016877172
VERSION     XP_016877172.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021683.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..573
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..573
                     /product="ribosomal protein S6 kinase-like 1 isoform X3"
                     /calculated_mol_wt=62498
     Region          48..122
                     /region_name="MIT_SNX15"
                     /note="MIT: domain contained within Microtubule
                     Interacting and Trafficking molecules. This MIT domain
                     sub-family is found in sorting nexin 15 and related
                     proteins. The molecular function of the MIT domain is
                     unclear; cd02677"
                     /db_xref="CDD:239140"
     Region          148..525
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Site            order(154..157,160,178,191,193,217,233..236,428,432..433,
                     435)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270870"
     CDS             1..573
                     /gene="RPS6KL1"
                     /gene_synonym="RSKL2"
                     /coded_by="XM_017021683.3:610..2331"
                     /db_xref="GeneID:83694"
                     /db_xref="HGNC:HGNC:20222"
ORIGIN      
        1 mslvaceclp spglepepcs rarsqahvyl eqirnrvalg vpdmtkrdyl vdaatqirla
       61 lerdvsedye aafnhyqngv dvllrgihvd pnkerreavk lkitkylrra eeifnchlqr
      121 plssgaspsa gfsslrlrpi rtlssaveql rgcrvvgvie krdlavlprl vsnslpqvql
      181 vqdpatggtf vvkslprchm vsrerltiip hgvpymtkll ryfvsedsif lhlehvqggt
      241 lwshllsqah srhsglssgs tqermkaqln phlnlltpar lpsghapgqd rialepprts
      301 pnlllageap strpqreaeg eptartstsg ssdlpkapgg hlhlqarrag qnsdagpprg
      361 ltwvpegagp vlggcgrgmd qsclsadgag rgcgratwsv reeqvkqwaa emlvalealh
      421 eqgvlcrdlh pgnllldqae vggiseltea cdwwsfgsll yelltgmals qshpsgiqah
      481 tqlqlpewls rpaaslltel lqfeptrrlg mgeggvsklk shpffstiqw sklvgalvll
      541 sgthfppvtd lhrgmaslqe lsrqglwkrq gcv
//
LOCUS       XP_016877173             571 aa            linear   PRI 05-AUG-2025
DEFINITION  ribosomal protein S6 kinase-like 1 isoform X4 [Homo sapiens].
ACCESSION   XP_016877173
VERSION     XP_016877173.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021684.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..571
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..571
                     /product="ribosomal protein S6 kinase-like 1 isoform X4"
                     /calculated_mol_wt=62400
     Region          48..122
                     /region_name="MIT_SNX15"
                     /note="MIT: domain contained within Microtubule
                     Interacting and Trafficking molecules. This MIT domain
                     sub-family is found in sorting nexin 15 and related
                     proteins. The molecular function of the MIT domain is
                     unclear; cd02677"
                     /db_xref="CDD:239140"
     Region          148..523
                     /region_name="STKc_RPK118_like"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     RPK118, and similar proteins; cd05576"
                     /db_xref="CDD:270728"
     Site            order(154..158,178,191,193,217,233..234,236,240,242,428,
                     430,432..433,435,445..446,449,460..465,492)
                     /site_type="active"
                     /db_xref="CDD:270728"
     Site            order(154..158,178,191,193,217,234..236,240,428,430,
                     432..433,435,445..446)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270728"
     Site            order(158,240,242,428,430,432,449,460..465,492)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270728"
     Site            445..465
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270728"
     CDS             1..571
                     /gene="RPS6KL1"
                     /gene_synonym="RSKL2"
                     /coded_by="XM_017021684.3:610..2325"
                     /db_xref="GeneID:83694"
                     /db_xref="HGNC:HGNC:20222"
ORIGIN      
        1 mslvaceclp spglepepcs rarsqahvyl eqirnrvalg vpdmtkrdyl vdaatqirla
       61 lerdvsedye aafnhyqngv dvllrgihvd pnkerreavk lkitkylrra eeifnchlqr
      121 plssgaspsa gfsslrlrpi rtlssaveql rgcrvvgvie krdlavlprl vsnslpqvql
      181 vqdpatggtf vvkslprchm vsrerltiip hgvpymtkll ryfvsedsif lhlehvqggt
      241 lwshllsqah srhsglssgs tqermkaqln phlnlltpar lpsghapgqd rialepprts
      301 pnlllageap strpqreaeg eptartstsg ssdlpkapgg hlhlqarrag qnsdagpprg
      361 ltwvpegagp vlggcgrgmd qsclsadgag rgcgratwsv reeqvkqwaa emlvalealh
      421 eqgvlcrdlh pgnllldqag hirltyfgqw sevepqccge avdnlysape vggiseltea
      481 cdwwsfgsll yelltgmllq feptrrlgmg eggvsklksh pffstiqwsk lvgalvllsg
      541 thfppvtdlh rgmaslqels rqglwkrqgc v
//
LOCUS       XP_016877174             569 aa            linear   PRI 05-AUG-2025
DEFINITION  ribosomal protein S6 kinase-like 1 isoform X5 [Homo sapiens].
ACCESSION   XP_016877174
VERSION     XP_016877174.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021685.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..569
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..569
                     /product="ribosomal protein S6 kinase-like 1 isoform X5"
                     /calculated_mol_wt=62179
     Region          48..122
                     /region_name="MIT_SNX15"
                     /note="MIT: domain contained within Microtubule
                     Interacting and Trafficking molecules. This MIT domain
                     sub-family is found in sorting nexin 15 and related
                     proteins. The molecular function of the MIT domain is
                     unclear; cd02677"
                     /db_xref="CDD:239140"
     Region          148..555
                     /region_name="STKc_RPK118_like"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     RPK118, and similar proteins; cd05576"
                     /db_xref="CDD:270728"
     Site            order(154..158,178,191,193,217,233..234,236,240,242,428,
                     430,432..433,435,445..446,449,460..465,492,498,501)
                     /site_type="active"
                     /db_xref="CDD:270728"
     Site            order(154..158,178,191,193,217,234..236,240,428,430,
                     432..433,435,445..446)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270728"
     Site            order(158,240,242,428,430,432,449,460..465,492,498,501)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270728"
     Site            445..465
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270728"
     CDS             1..569
                     /gene="RPS6KL1"
                     /gene_synonym="RSKL2"
                     /coded_by="XM_017021685.3:610..2319"
                     /db_xref="GeneID:83694"
                     /db_xref="HGNC:HGNC:20222"
ORIGIN      
        1 mslvaceclp spglepepcs rarsqahvyl eqirnrvalg vpdmtkrdyl vdaatqirla
       61 lerdvsedye aafnhyqngv dvllrgihvd pnkerreavk lkitkylrra eeifnchlqr
      121 plssgaspsa gfsslrlrpi rtlssaveql rgcrvvgvie krdlavlprl vsnslpqvql
      181 vqdpatggtf vvkslprchm vsrerltiip hgvpymtkll ryfvsedsif lhlehvqggt
      241 lwshllsqah srhsglssgs tqermkaqln phlnlltpar lpsghapgqd rialepprts
      301 pnlllageap strpqreaeg eptartstsg ssdlpkapgg hlhlqarrag qnsdagpprg
      361 ltwvpegagp vlggcgrgmd qsclsadgag rgcgratwsv reeqvkqwaa emlvalealh
      421 eqgvlcrdlh pgnllldqag hirltyfgqw sevepqccge avdnlysape vggiseltea
      481 cdwwsfgsll yelltgmals qshpsgiqah tqlqlpewls rpaaslltel lqfeptrrlg
      541 mgeggvsklk shpffstiqw sklvgqqtr
//
LOCUS       XP_011535513             556 aa            linear   PRI 05-AUG-2025
DEFINITION  ribosomal protein S6 kinase-like 1 isoform X6 [Homo sapiens].
ACCESSION   XP_011535513
VERSION     XP_011535513.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537211.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..556
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..556
                     /product="ribosomal protein S6 kinase-like 1 isoform X6"
                     /calculated_mol_wt=60680
     Region          48..122
                     /region_name="MIT_SNX15"
                     /note="MIT: domain contained within Microtubule
                     Interacting and Trafficking molecules. This MIT domain
                     sub-family is found in sorting nexin 15 and related
                     proteins. The molecular function of the MIT domain is
                     unclear; cd02677"
                     /db_xref="CDD:239140"
     Region          131..508
                     /region_name="STKc_RPK118_like"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     RPK118, and similar proteins; cd05576"
                     /db_xref="CDD:270728"
     Site            order(131,144,146,170,186..187,189,193,195,381,383,
                     385..386,388,398..399,402,413..418,445,451,454)
                     /site_type="active"
                     /db_xref="CDD:270728"
     Site            order(193,195,381,383,385,402,413..418,445,451,454)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270728"
     Site            398..418
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270728"
     CDS             1..556
                     /gene="RPS6KL1"
                     /gene_synonym="RSKL2"
                     /coded_by="XM_011537211.4:610..2280"
                     /db_xref="GeneID:83694"
                     /db_xref="HGNC:HGNC:20222"
ORIGIN      
        1 mslvaceclp spglepepcs rarsqahvyl eqirnrvalg vpdmtkrdyl vdaatqirla
       61 lerdvsedye aafnhyqngv dvllrgihvd pnkerreavk lkitkylrra eeifnchlqr
      121 plssgaspsa vqlvqdpatg gtfvvkslpr chmvsrerlt iiphgvpymt kllryfvsed
      181 siflhlehvq ggtlwshlls qahsrhsgls sgstqermka qlnphlnllt parlpsghap
      241 gqdrialepp rtspnlllag eapstrpqre aegeptarts tsgssdlpka pgghlhlqar
      301 ragqnsdagp prgltwvpeg agpvlggcgr gmdqsclsad gagrgcgrat wsvreeqvkq
      361 waaemlvale alheqgvlcr dlhpgnllld qaghirltyf gqwsevepqc cgeavdnlys
      421 apevggisel teacdwwsfg sllyelltgm alsqshpsgi qahtqlqlpe wlsrpaasll
      481 tellqfeptr rlgmgeggvs klkshpffst iqwsklvgal vllsgthfpp vtdlhrgmas
      541 lqelsrqglw krqgcv
//
LOCUS       XP_047287753             556 aa            linear   PRI 05-AUG-2025
DEFINITION  ribosomal protein S6 kinase-like 1 isoform X6 [Homo sapiens].
ACCESSION   XP_047287753
VERSION     XP_047287753.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431797.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..556
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..556
                     /product="ribosomal protein S6 kinase-like 1 isoform X6"
                     /calculated_mol_wt=60680
     Region          48..122
                     /region_name="MIT_SNX15"
                     /note="MIT: domain contained within Microtubule
                     Interacting and Trafficking molecules. This MIT domain
                     sub-family is found in sorting nexin 15 and related
                     proteins. The molecular function of the MIT domain is
                     unclear; cd02677"
                     /db_xref="CDD:239140"
     Region          131..508
                     /region_name="STKc_RPK118_like"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     RPK118, and similar proteins; cd05576"
                     /db_xref="CDD:270728"
     Site            order(131,144,146,170,186..187,189,193,195,381,383,
                     385..386,388,398..399,402,413..418,445,451,454)
                     /site_type="active"
                     /db_xref="CDD:270728"
     Site            order(193,195,381,383,385,402,413..418,445,451,454)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270728"
     Site            398..418
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270728"
     CDS             1..556
                     /gene="RPS6KL1"
                     /gene_synonym="RSKL2"
                     /coded_by="XM_047431797.1:102..1772"
                     /db_xref="GeneID:83694"
                     /db_xref="HGNC:HGNC:20222"
ORIGIN      
        1 mslvaceclp spglepepcs rarsqahvyl eqirnrvalg vpdmtkrdyl vdaatqirla
       61 lerdvsedye aafnhyqngv dvllrgihvd pnkerreavk lkitkylrra eeifnchlqr
      121 plssgaspsa vqlvqdpatg gtfvvkslpr chmvsrerlt iiphgvpymt kllryfvsed
      181 siflhlehvq ggtlwshlls qahsrhsgls sgstqermka qlnphlnllt parlpsghap
      241 gqdrialepp rtspnlllag eapstrpqre aegeptarts tsgssdlpka pgghlhlqar
      301 ragqnsdagp prgltwvpeg agpvlggcgr gmdqsclsad gagrgcgrat wsvreeqvkq
      361 waaemlvale alheqgvlcr dlhpgnllld qaghirltyf gqwsevepqc cgeavdnlys
      421 apevggisel teacdwwsfg sllyelltgm alsqshpsgi qahtqlqlpe wlsrpaasll
      481 tellqfeptr rlgmgeggvs klkshpffst iqwsklvgal vllsgthfpp vtdlhrgmas
      541 lqelsrqglw krqgcv
//
LOCUS       XP_011535515             540 aa            linear   PRI 05-AUG-2025
DEFINITION  ribosomal protein S6 kinase-like 1 isoform X7 [Homo sapiens].
ACCESSION   XP_011535515
VERSION     XP_011535515.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537213.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..540
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..540
                     /product="ribosomal protein S6 kinase-like 1 isoform X7"
                     /calculated_mol_wt=59039
     Region          48..122
                     /region_name="MIT_SNX15"
                     /note="MIT: domain contained within Microtubule
                     Interacting and Trafficking molecules. This MIT domain
                     sub-family is found in sorting nexin 15 and related
                     proteins. The molecular function of the MIT domain is
                     unclear; cd02677"
                     /db_xref="CDD:239140"
     Region          131..492
                     /region_name="STKc_RPK118_like"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     RPK118, and similar proteins; cd05576"
                     /db_xref="CDD:270728"
     Site            order(177,179,365,367,369,386,397..402,429,435,438)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270728"
     Site            382..402
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270728"
     CDS             1..540
                     /gene="RPS6KL1"
                     /gene_synonym="RSKL2"
                     /coded_by="XM_011537213.4:610..2232"
                     /db_xref="GeneID:83694"
                     /db_xref="HGNC:HGNC:20222"
ORIGIN      
        1 mslvaceclp spglepepcs rarsqahvyl eqirnrvalg vpdmtkrdyl vdaatqirla
       61 lerdvsedye aafnhyqngv dvllrgihvd pnkerreavk lkitkylrra eeifnchlqr
      121 plssgaspsa slprchmvsr erltiiphgv pymtkllryf vsedsiflhl ehvqggtlws
      181 hllsqahsrh sglssgstqe rmkaqlnphl nlltparlps ghapgqdria lepprtspnl
      241 llageapstr pqreaegept artstsgssd lpkapgghlh lqarragqns dagpprgltw
      301 vpegagpvlg gcgrgmdqsc lsadgagrgc gratwsvree qvkqwaaeml valealheqg
      361 vlcrdlhpgn llldqaghir ltyfgqwsev epqccgeavd nlysapevgg iselteacdw
      421 wsfgsllyel ltgmalsqsh psgiqahtql qlpewlsrpa aslltellqf eptrrlgmge
      481 ggvsklkshp ffstiqwskl vgalvllsgt hfppvtdlhr gmaslqelsr qglwkrqgcv
//
LOCUS       XP_047287754             523 aa            linear   PRI 05-AUG-2025
DEFINITION  ribosomal protein S6 kinase-like 1 isoform X8 [Homo sapiens].
ACCESSION   XP_047287754
VERSION     XP_047287754.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431798.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..523
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..523
                     /product="ribosomal protein S6 kinase-like 1 isoform X8"
                     /calculated_mol_wt=57066
     Region          48..122
                     /region_name="MIT_SNX15"
                     /note="MIT: domain contained within Microtubule
                     Interacting and Trafficking molecules. This MIT domain
                     sub-family is found in sorting nexin 15 and related
                     proteins. The molecular function of the MIT domain is
                     unclear; cd02677"
                     /db_xref="CDD:239140"
     Region          148..509
                     /region_name="STKc_RPK118_like"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     RPK118, and similar proteins; cd05576"
                     /db_xref="CDD:270728"
     Site            order(154..158,162,175,177,201,218..220,224,412,414,
                     416..417,419)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270728"
     CDS             1..523
                     /gene="RPS6KL1"
                     /gene_synonym="RSKL2"
                     /coded_by="XM_047431798.1:610..2181"
                     /db_xref="GeneID:83694"
                     /db_xref="HGNC:HGNC:20222"
ORIGIN      
        1 mslvaceclp spglepepcs rarsqahvyl eqirnrvalg vpdmtkrdyl vdaatqirla
       61 lerdvsedye aafnhyqngv dvllrgihvd pnkerreavk lkitkylrra eeifnchlqr
      121 plssgaspsa gfsslrlrpi rtlssaveql rgcrvvgvie kvqlvqdpat ggtfvvkslp
      181 rchmvsrerl tiiphgvpym tkllryfvse dsiflhlehv qggtlwshll sqahsrhsgl
      241 ssgstqermk aqlnphlnll tparlpsgha pgqdrialep prtspnllla geapstrpqr
      301 eaegeptart stsgssdlpk apgghlhlqa rragqnsdag pprgltwvpe gagpvlggcg
      361 rgmdqsclsa dgagrgcgra twsvreeqvk qwaaemlval ealheqgvlc rdlhpgnlll
      421 dqaevggise lteacdwwsf gsllyelltg malsqshpsg iqahtqlqlp ewlsrpaasl
      481 ltellqfept rrlgmgeggv sklkshpffs tiqwsklvgq qtr
//
LOCUS       XP_047287755             522 aa            linear   PRI 05-AUG-2025
DEFINITION  ribosomal protein S6 kinase-like 1 isoform X9 [Homo sapiens].
ACCESSION   XP_047287755
VERSION     XP_047287755.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431799.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..522
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..522
                     /product="ribosomal protein S6 kinase-like 1 isoform X9"
                     /calculated_mol_wt=57009
     Region          48..122
                     /region_name="MIT_SNX15"
                     /note="MIT: domain contained within Microtubule
                     Interacting and Trafficking molecules. This MIT domain
                     sub-family is found in sorting nexin 15 and related
                     proteins. The molecular function of the MIT domain is
                     unclear; cd02677"
                     /db_xref="CDD:239140"
     Region          131..508
                     /region_name="STKc_RPK118_like"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     RPK118, and similar proteins; cd05576"
                     /db_xref="CDD:270728"
     Site            order(131,144,146,170,186..187,189,193,195,381,383,
                     385..386,388,398..399,402,413..418,445,451,454)
                     /site_type="active"
                     /db_xref="CDD:270728"
     Site            order(193,195,381,383,385,402,413..418,445,451,454)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270728"
     Site            398..418
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270728"
     CDS             1..522
                     /gene="RPS6KL1"
                     /gene_synonym="RSKL2"
                     /coded_by="XM_047431799.1:610..2178"
                     /db_xref="GeneID:83694"
                     /db_xref="HGNC:HGNC:20222"
ORIGIN      
        1 mslvaceclp spglepepcs rarsqahvyl eqirnrvalg vpdmtkrdyl vdaatqirla
       61 lerdvsedye aafnhyqngv dvllrgihvd pnkerreavk lkitkylrra eeifnchlqr
      121 plssgaspsa vqlvqdpatg gtfvvkslpr chmvsrerlt iiphgvpymt kllryfvsed
      181 siflhlehvq ggtlwshlls qahsrhsgls sgstqermka qlnphlnllt parlpsghap
      241 gqdrialepp rtspnlllag eapstrpqre aegeptarts tsgssdlpka pgghlhlqar
      301 ragqnsdagp prgltwvpeg agpvlggcgr gmdqsclsad gagrgcgrat wsvreeqvkq
      361 waaemlvale alheqgvlcr dlhpgnllld qaghirltyf gqwsevepqc cgeavdnlys
      421 apevggisel teacdwwsfg sllyelltgm alsqshpsgi qahtqlqlpe wlsrpaasll
      481 tellqfeptr rlgmgeggvs klkshpffst iqwsklvgqq tr
//
LOCUS       XP_016877175             471 aa            linear   PRI 05-AUG-2025
DEFINITION  ribosomal protein S6 kinase-like 1 isoform X10 [Homo sapiens].
ACCESSION   XP_016877175
VERSION     XP_016877175.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021686.3
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 1% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..471
                     /product="ribosomal protein S6 kinase-like 1 isoform X10"
                     /calculated_mol_wt=51119
     Region          48..122
                     /region_name="MIT_SNX15"
                     /note="MIT: domain contained within Microtubule
                     Interacting and Trafficking molecules. This MIT domain
                     sub-family is found in sorting nexin 15 and related
                     proteins. The molecular function of the MIT domain is
                     unclear; cd02677"
                     /db_xref="CDD:239140"
     Region          148..>439
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Site            order(154..157,160,178,191,193,217,233..236,428,432..433,
                     435)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270870"
     CDS             1..471
                     /gene="RPS6KL1"
                     /gene_synonym="RSKL2"
                     /coded_by="XM_017021686.3:610..2025"
                     /db_xref="GeneID:83694"
                     /db_xref="HGNC:HGNC:20222"
ORIGIN      
        1 mslvaceclp spglepepcs rarsqahvyl eqirnrvalg vpdmtkrdyl vdaatqirla
       61 lerdvsedye aafnhyqngv dvllrgihvd pnkerreavk lkitkylrra eeifnchlqr
      121 plssgaspsa gfsslrlrpi rtlssaveql rgcrvvgvie krdlavlprl vsnslpqvql
      181 vqdpatggtf vvkslprchm vsrerltiip hgvpymtkll ryfvsedsif lhlehvqggt
      241 lwshllsqah srhsglssgs tqermkaqln phlnlltpar lpsghapgqd rialepprts
      301 pnlllageap strpqreaeg eptartstsg ssdlpkapgg hlhlqarrag qnsdagpprg
      361 ltwvpegagp vlggcgrgmd qsclsadgag rgcgratwsv reeqvkqwaa emlvalealh
      421 eqgvlcrdlh pgnllldqav vrggapvlrg grgqslqrpr ggwdfradgs l
//
LOCUS       XP_016877177             401 aa            linear   PRI 05-AUG-2025
DEFINITION  ribosomal protein S6 kinase-like 1 isoform X11 [Homo sapiens].
ACCESSION   XP_016877177
VERSION     XP_016877177.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021688.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..401
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..401
                     /product="ribosomal protein S6 kinase-like 1 isoform X11"
                     /calculated_mol_wt=44679
     Region          48..122
                     /region_name="MIT_SNX15"
                     /note="MIT: domain contained within Microtubule
                     Interacting and Trafficking molecules. This MIT domain
                     sub-family is found in sorting nexin 15 and related
                     proteins. The molecular function of the MIT domain is
                     unclear; cd02677"
                     /db_xref="CDD:239140"
     Region          148..353
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..401
                     /gene="RPS6KL1"
                     /gene_synonym="RSKL2"
                     /coded_by="XM_017021688.3:610..1815"
                     /db_xref="GeneID:83694"
                     /db_xref="HGNC:HGNC:20222"
ORIGIN      
        1 mslvaceclp spglepepcs rarsqahvyl eqirnrvalg vpdmtkrdyl vdaatqirla
       61 lerdvsedye aafnhyqngv dvllrgihvd pnkerreavk lkitkylrra eeifnchlqr
      121 plssgaspsa gfsslrlrpi rtlssaveql rgcrvvgvie krdlavlprl vsnslpqvql
      181 vqdpatggtf vvkslprchm vsrerltiip hgvpymtkll ryfvsedsif lhlehvqghi
      241 rltyfgqwse vepqccgeav dnlysapevg giselteacd wwsfgsllye lltgmalsqs
      301 hpsgiqahtq lqlpewlsrp aaslltellq feptrrlgmg eggvsklksh pffstiqwsk
      361 lvgalvllsg thfppvtdlh rgmaslqels rqglwkrqgc v
//
LOCUS       XP_047287756             354 aa            linear   PRI 05-AUG-2025
DEFINITION  ribosomal protein S6 kinase-like 1 isoform X12 [Homo sapiens].
ACCESSION   XP_047287756
VERSION     XP_047287756.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431800.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..354
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..354
                     /product="ribosomal protein S6 kinase-like 1 isoform X12"
                     /calculated_mol_wt=39508
     Region          48..122
                     /region_name="MIT_SNX15"
                     /note="MIT: domain contained within Microtubule
                     Interacting and Trafficking molecules. This MIT domain
                     sub-family is found in sorting nexin 15 and related
                     proteins. The molecular function of the MIT domain is
                     unclear; cd02677"
                     /db_xref="CDD:239140"
     Region          131..306
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..354
                     /gene="RPS6KL1"
                     /gene_synonym="RSKL2"
                     /coded_by="XM_047431800.1:610..1674"
                     /db_xref="GeneID:83694"
                     /db_xref="HGNC:HGNC:20222"
ORIGIN      
        1 mslvaceclp spglepepcs rarsqahvyl eqirnrvalg vpdmtkrdyl vdaatqirla
       61 lerdvsedye aafnhyqngv dvllrgihvd pnkerreavk lkitkylrra eeifnchlqr
      121 plssgaspsa vqlvqdpatg gtfvvkslpr chmvsrerlt iiphgvpymt kllryfvsed
      181 siflhlehvq ghirltyfgq wsevepqccg eavdnlysap evggiselte acdwwsfgsl
      241 lyelltgmal sqshpsgiqa htqlqlpewl srpaasllte llqfeptrrl gmgeggvskl
      301 kshpffstiq wsklvgalvl lsgthfppvt dlhrgmaslq elsrqglwkr qgcv
//
LOCUS       XP_047287757             347 aa            linear   PRI 05-AUG-2025
DEFINITION  ribosomal protein S6 kinase-like 1 isoform X13 [Homo sapiens].
ACCESSION   XP_047287757
VERSION     XP_047287757.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431801.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..347
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..347
                     /product="ribosomal protein S6 kinase-like 1 isoform X13"
                     /calculated_mol_wt=38734
     Region          48..122
                     /region_name="MIT_SNX15"
                     /note="MIT: domain contained within Microtubule
                     Interacting and Trafficking molecules. This MIT domain
                     sub-family is found in sorting nexin 15 and related
                     proteins. The molecular function of the MIT domain is
                     unclear; cd02677"
                     /db_xref="CDD:239140"
     Region          148..337
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..347
                     /gene="RPS6KL1"
                     /gene_synonym="RSKL2"
                     /coded_by="XM_047431801.1:610..1653"
                     /db_xref="GeneID:83694"
                     /db_xref="HGNC:HGNC:20222"
ORIGIN      
        1 mslvaceclp spglepepcs rarsqahvyl eqirnrvalg vpdmtkrdyl vdaatqirla
       61 lerdvsedye aafnhyqngv dvllrgihvd pnkerreavk lkitkylrra eeifnchlqr
      121 plssgaspsa gfsslrlrpi rtlssaveql rgcrvvgvie kvqlvqdpat ggtfvvkslp
      181 rchmvsrerl tiiphgvpym tkllryfvse dsiflhlehv qghirltyfg qwsevepqcc
      241 geavdnlysa pevggiselt eacdwwsfgs llyelltgma lsqshpsgiq ahtqlqlpew
      301 lsrpaasllt ellqfeptrr lgmgeggvsk lkshpffsti qwsklvg
//
LOCUS       XP_016877180             324 aa            linear   PRI 05-AUG-2025
DEFINITION  ribosomal protein S6 kinase-like 1 isoform X14 [Homo sapiens].
ACCESSION   XP_016877180
VERSION     XP_016877180.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021691.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..324
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..324
                     /product="ribosomal protein S6 kinase-like 1 isoform X14"
                     /calculated_mol_wt=36156
     Region          48..122
                     /region_name="MIT_SNX15"
                     /note="MIT: domain contained within Microtubule
                     Interacting and Trafficking molecules. This MIT domain
                     sub-family is found in sorting nexin 15 and related
                     proteins. The molecular function of the MIT domain is
                     unclear; cd02677"
                     /db_xref="CDD:239140"
     Region          131..276
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..324
                     /gene="RPS6KL1"
                     /gene_synonym="RSKL2"
                     /coded_by="XM_017021691.3:610..1584"
                     /db_xref="GeneID:83694"
                     /db_xref="HGNC:HGNC:20222"
ORIGIN      
        1 mslvaceclp spglepepcs rarsqahvyl eqirnrvalg vpdmtkrdyl vdaatqirla
       61 lerdvsedye aafnhyqngv dvllrgihvd pnkerreavk lkitkylrra eeifnchlqr
      121 plssgaspsa vqlvqdpatg gtfvvkslpr chmvsrerlt iiphgvpymt kllryfvsed
      181 siflhlehvq evggiselte acdwwsfgsl lyelltgmal sqshpsgiqa htqlqlpewl
      241 srpaasllte llqfeptrrl gmgeggvskl kshpffstiq wsklvgalvl lsgthfppvt
      301 dlhrgmaslq elsrqglwkr qgcv
//
LOCUS       XP_047287758             645 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-16 isoform X1 [Homo sapiens].
ACCESSION   XP_047287758
VERSION     XP_047287758.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431802.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..645
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..645
                     /product="synaptotagmin-16 isoform X1"
                     /calculated_mol_wt=72143
     Region          350..473
                     /region_name="C2A_Synaptotagmin-14_16"
                     /note="C2A domain first repeat present in Synaptotagmins
                     14 and 16; cd08389"
                     /db_xref="CDD:176035"
     Region          506..643
                     /region_name="C2B_Synaptotagmin-14_16"
                     /note="C2 domain second repeat present in Synaptotagmins
                     14 and 16; cd08408"
                     /db_xref="CDD:176053"
     CDS             1..645
                     /gene="SYT16"
                     /gene_synonym="CHR14SYT; Strep14; SYT14L; syt14r"
                     /coded_by="XM_047431802.1:145..2082"
                     /db_xref="GeneID:83851"
                     /db_xref="HGNC:HGNC:23142"
                     /db_xref="MIM:610950"
ORIGIN      
        1 mvlamasqdv qnffqpfssw isrvyealqq agdmlsaslv niskqdskls dkldqdldni
       61 qiqetyfede eqdndwsqed anslflevdh fsccnsdlqd saqnsspsls qhakdscstm
      121 sqwpnwasdd rklphvlssi aeeehhlekq rsglqhgfds qlpgtletvn gkkqvnsfgd
      181 deelstssds deevikqfei svsrsqsfrs vtsekgkqtg leqkpkfsrs llthgedgte
      241 vsacedldga sqrrysenls ygeddhipah sqspcergda khhgtshqes svvqslrrqs
      301 tegslemeta fnsrgfedsy atdsssmwsp eeqdrtnlqv psgvsepisk cgdldvifey
      361 raasqkltvt ivraqglpdk drsgvnswqv hvvllpgkkh rgrtniqrgp npvfrekvtf
      421 akleprdvaa cavrfrlyaa rkmtrermmg eklfylshlh pegemkvtlv leprsnissg
      481 gsplspsavs hsdstsstqs lshggapell vglsynattg rlsvemikgs hfrnlavnra
      541 pdtygklfll nsvgqemsrc ktsirrgqpn pvyketfvfq valfqlsdvt lmisvynrrt
      601 mkrkemigwi algqnssgee eqdhweemke tkgqqicrwh tlles
//
LOCUS       XP_047287759             645 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-16 isoform X1 [Homo sapiens].
ACCESSION   XP_047287759
VERSION     XP_047287759.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431803.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..645
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..645
                     /product="synaptotagmin-16 isoform X1"
                     /calculated_mol_wt=72143
     Region          350..473
                     /region_name="C2A_Synaptotagmin-14_16"
                     /note="C2A domain first repeat present in Synaptotagmins
                     14 and 16; cd08389"
                     /db_xref="CDD:176035"
     Region          506..643
                     /region_name="C2B_Synaptotagmin-14_16"
                     /note="C2 domain second repeat present in Synaptotagmins
                     14 and 16; cd08408"
                     /db_xref="CDD:176053"
     CDS             1..645
                     /gene="SYT16"
                     /gene_synonym="CHR14SYT; Strep14; SYT14L; syt14r"
                     /coded_by="XM_047431803.1:145..2082"
                     /db_xref="GeneID:83851"
                     /db_xref="HGNC:HGNC:23142"
                     /db_xref="MIM:610950"
ORIGIN      
        1 mvlamasqdv qnffqpfssw isrvyealqq agdmlsaslv niskqdskls dkldqdldni
       61 qiqetyfede eqdndwsqed anslflevdh fsccnsdlqd saqnsspsls qhakdscstm
      121 sqwpnwasdd rklphvlssi aeeehhlekq rsglqhgfds qlpgtletvn gkkqvnsfgd
      181 deelstssds deevikqfei svsrsqsfrs vtsekgkqtg leqkpkfsrs llthgedgte
      241 vsacedldga sqrrysenls ygeddhipah sqspcergda khhgtshqes svvqslrrqs
      301 tegslemeta fnsrgfedsy atdsssmwsp eeqdrtnlqv psgvsepisk cgdldvifey
      361 raasqkltvt ivraqglpdk drsgvnswqv hvvllpgkkh rgrtniqrgp npvfrekvtf
      421 akleprdvaa cavrfrlyaa rkmtrermmg eklfylshlh pegemkvtlv leprsnissg
      481 gsplspsavs hsdstsstqs lshggapell vglsynattg rlsvemikgs hfrnlavnra
      541 pdtygklfll nsvgqemsrc ktsirrgqpn pvyketfvfq valfqlsdvt lmisvynrrt
      601 mkrkemigwi algqnssgee eqdhweemke tkgqqicrwh tlles
//
LOCUS       XP_024305494             551 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-16 isoform X2 [Homo sapiens].
ACCESSION   XP_024305494
VERSION     XP_024305494.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449726.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..551
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..551
                     /product="synaptotagmin-16 isoform X2"
                     /calculated_mol_wt=61009
     Region          350..473
                     /region_name="C2A_Synaptotagmin-14_16"
                     /note="C2A domain first repeat present in Synaptotagmins
                     14 and 16; cd08389"
                     /db_xref="CDD:176035"
     Region          506..>541
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     CDS             1..551
                     /gene="SYT16"
                     /gene_synonym="CHR14SYT; Strep14; SYT14L; syt14r"
                     /coded_by="XM_024449726.2:145..1800"
                     /db_xref="GeneID:83851"
                     /db_xref="HGNC:HGNC:23142"
                     /db_xref="MIM:610950"
ORIGIN      
        1 mvlamasqdv qnffqpfssw isrvyealqq agdmlsaslv niskqdskls dkldqdldni
       61 qiqetyfede eqdndwsqed anslflevdh fsccnsdlqd saqnsspsls qhakdscstm
      121 sqwpnwasdd rklphvlssi aeeehhlekq rsglqhgfds qlpgtletvn gkkqvnsfgd
      181 deelstssds deevikqfei svsrsqsfrs vtsekgkqtg leqkpkfsrs llthgedgte
      241 vsacedldga sqrrysenls ygeddhipah sqspcergda khhgtshqes svvqslrrqs
      301 tegslemeta fnsrgfedsy atdsssmwsp eeqdrtnlqv psgvsepisk cgdldvifey
      361 raasqkltvt ivraqglpdk drsgvnswqv hvvllpgkkh rgrtniqrgp npvfrekvtf
      421 akleprdvaa cavrfrlyaa rkmtrermmg eklfylshlh pegemkvtlv leprsnissg
      481 gsplspsavs hsdstsstqs lshggapell vglsynattg rlsvemikgs hfrnlavnra
      541 pakklergag r
//
LOCUS       XP_047287760             533 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-16 isoform X3 [Homo sapiens].
ACCESSION   XP_047287760
VERSION     XP_047287760.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431804.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..533
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..533
                     /product="synaptotagmin-16 isoform X3"
                     /calculated_mol_wt=59307
     Region          238..361
                     /region_name="C2A_Synaptotagmin-14_16"
                     /note="C2A domain first repeat present in Synaptotagmins
                     14 and 16; cd08389"
                     /db_xref="CDD:176035"
     Region          394..531
                     /region_name="C2B_Synaptotagmin-14_16"
                     /note="C2 domain second repeat present in Synaptotagmins
                     14 and 16; cd08408"
                     /db_xref="CDD:176053"
     CDS             1..533
                     /gene="SYT16"
                     /gene_synonym="CHR14SYT; Strep14; SYT14L; syt14r"
                     /coded_by="XM_047431804.1:2450..4051"
                     /db_xref="GeneID:83851"
                     /db_xref="HGNC:HGNC:23142"
                     /db_xref="MIM:610950"
ORIGIN      
        1 mlvtpeaigf lsavgvfivl lavlflfink klcfetiggl pflehrgkrk hskdktgihk
       61 glvnsfgdde elstssdsde evikqfeisv srsqsfrsvt sekgkqtgle qkpkfsrsll
      121 thgedgtevs acedldgasq rrysenlsyg eddhipahsq spcergdakh hgtshqessv
      181 vqslrrqste gslemetafn srgfedsyat dsssmwspee qdrtnlqvps gvsepiskcg
      241 dldvifeyra asqkltvtiv raqglpdkdr sgvnswqvhv vllpgkkhrg rtniqrgpnp
      301 vfrekvtfak leprdvaaca vrfrlyaark mtrermmgek lfylshlhpe gemkvtlvle
      361 prsnissggs plspsavshs dstsstqsls hggapellvg lsynattgrl svemikgshf
      421 rnlavnrapd tygklfllns vgqemsrckt sirrgqpnpv yketfvfqva lfqlsdvtlm
      481 isvynrrtmk rkemigwial gqnssgeeeq dhweemketk gqqicrwhtl les
//
LOCUS       XP_011535529             505 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-16 isoform X4 [Homo sapiens].
ACCESSION   XP_011535529
VERSION     XP_011535529.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537227.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Jun 6, 2016 this sequence version replaced XP_011535529.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..505
                     /product="synaptotagmin-16 isoform X4"
                     /calculated_mol_wt=56349
     Region          210..333
                     /region_name="C2A_Synaptotagmin-14_16"
                     /note="C2A domain first repeat present in Synaptotagmins
                     14 and 16; cd08389"
                     /db_xref="CDD:176035"
     Region          366..503
                     /region_name="C2B_Synaptotagmin-14_16"
                     /note="C2 domain second repeat present in Synaptotagmins
                     14 and 16; cd08408"
                     /db_xref="CDD:176053"
     CDS             1..505
                     /gene="SYT16"
                     /gene_synonym="CHR14SYT; Strep14; SYT14L; syt14r"
                     /coded_by="XM_011537227.2:15..1532"
                     /db_xref="GeneID:83851"
                     /db_xref="HGNC:HGNC:23142"
                     /db_xref="MIM:610950"
ORIGIN      
        1 mtygfelsql hrndlmlgif esprgdplgl akervnsfgd deelstssds deevikqfei
       61 svsrsqsfrs vtsekgkqtg leqkpkfsrs llthgedgte vsacedldga sqrrysenls
      121 ygeddhipah sqspcergda khhgtshqes svvqslrrqs tegslemeta fnsrgfedsy
      181 atdsssmwsp eeqdrtnlqv psgvsepisk cgdldvifey raasqkltvt ivraqglpdk
      241 drsgvnswqv hvvllpgkkh rgrtniqrgp npvfrekvtf akleprdvaa cavrfrlyaa
      301 rkmtrermmg eklfylshlh pegemkvtlv leprsnissg gsplspsavs hsdstsstqs
      361 lshggapell vglsynattg rlsvemikgs hfrnlavnra pdtygklfll nsvgqemsrc
      421 ktsirrgqpn pvyketfvfq valfqlsdvt lmisvynrrt mkrkemigwi algqnssgee
      481 eqdhweemke tkgqqicrwh tlles
//
LOCUS       XP_016877186             434 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-16 isoform X5 [Homo sapiens].
ACCESSION   XP_016877186
VERSION     XP_016877186.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021697.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..434
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..434
                     /product="synaptotagmin-16 isoform X5"
                     /calculated_mol_wt=47564
     Region          240..363
                     /region_name="C2A_Synaptotagmin-14_16"
                     /note="C2A domain first repeat present in Synaptotagmins
                     14 and 16; cd08389"
                     /db_xref="CDD:176035"
     Region          396..>431
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     CDS             1..434
                     /gene="SYT16"
                     /gene_synonym="CHR14SYT; Strep14; SYT14L; syt14r"
                     /coded_by="XM_017021697.3:96..1400"
                     /db_xref="GeneID:83851"
                     /db_xref="HGNC:HGNC:23142"
                     /db_xref="MIM:610950"
ORIGIN      
        1 matditpeai gflsavgvfi vllavlflfi nkklcfetig glpflehrgk rkhskdktgi
       61 hkglvnsfgd deelstssds deevikqfei svsrsqsfrs vtsekgkqtg leqkpkfsrs
      121 llthgedgte vsacedldga sqrrysenls ygeddhipah sqspcergda khhgtshqes
      181 svvqslrrqs tegslemeta fnsrgfedsy atdsssmwsp eeqdrtnlqv psgvsepisk
      241 cgdldvifey raasqkltvt ivraqglpdk drsgvnswqv hvvllpgkkh rgrtniqrgp
      301 npvfrekvtf akleprdvaa cavrfrlyaa rkmtrermmg eklfylshlh pegemkvtlv
      361 leprsnissg gsplspsavs hsdstsstqs lshggapell vglsynattg rlsvemikgs
      421 hfrnlavnra pgvl
//
LOCUS       XP_011535531             424 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-16 isoform X6 [Homo sapiens].
ACCESSION   XP_011535531
VERSION     XP_011535531.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537229.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..424
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..424
                     /product="synaptotagmin-16 isoform X6"
                     /calculated_mol_wt=47368
     Region          129..252
                     /region_name="C2A_Synaptotagmin-14_16"
                     /note="C2A domain first repeat present in Synaptotagmins
                     14 and 16; cd08389"
                     /db_xref="CDD:176035"
     Region          285..422
                     /region_name="C2B_Synaptotagmin-14_16"
                     /note="C2 domain second repeat present in Synaptotagmins
                     14 and 16; cd08408"
                     /db_xref="CDD:176053"
     CDS             1..424
                     /gene="SYT16"
                     /gene_synonym="CHR14SYT; Strep14; SYT14L; syt14r"
                     /coded_by="XM_011537229.3:44..1318"
                     /db_xref="GeneID:83851"
                     /db_xref="HGNC:HGNC:23142"
                     /db_xref="MIM:610950"
ORIGIN      
        1 maetgfklgs yqsktmdqge nflldldgas qrrysenlsy geddhipahs qspcergdak
       61 hhgtshqess vvqslrrqst egslemetaf nsrgfedsya tdsssmwspe eqdrtnlqvp
      121 sgvsepiskc gdldvifeyr aasqkltvti vraqglpdkd rsgvnswqvh vvllpgkkhr
      181 grtniqrgpn pvfrekvtfa kleprdvaac avrfrlyaar kmtrermmge klfylshlhp
      241 egemkvtlvl eprsnissgg splspsavsh sdstsstqsl shggapellv glsynattgr
      301 lsvemikgsh frnlavnrap dtygklflln svgqemsrck tsirrgqpnp vyketfvfqv
      361 alfqlsdvtl misvynrrtm krkemigwia lgqnssgeee qdhweemket kgqqicrwht
      421 lles
//
LOCUS       XP_024305497             339 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-16 isoform X7 [Homo sapiens].
ACCESSION   XP_024305497
VERSION     XP_024305497.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449729.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..339
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..339
                     /product="synaptotagmin-16 isoform X7"
                     /calculated_mol_wt=37944
     Region          44..167
                     /region_name="C2A_Synaptotagmin-14_16"
                     /note="C2A domain first repeat present in Synaptotagmins
                     14 and 16; cd08389"
                     /db_xref="CDD:176035"
     Region          200..337
                     /region_name="C2B_Synaptotagmin-14_16"
                     /note="C2 domain second repeat present in Synaptotagmins
                     14 and 16; cd08408"
                     /db_xref="CDD:176053"
     CDS             1..339
                     /gene="SYT16"
                     /gene_synonym="CHR14SYT; Strep14; SYT14L; syt14r"
                     /coded_by="XM_024449729.2:654..1673"
                     /db_xref="GeneID:83851"
                     /db_xref="HGNC:HGNC:23142"
                     /db_xref="MIM:610950"
ORIGIN      
        1 metafnsrgf edsyatdsss mwspeeqdrt nlqvpsgvse piskcgdldv ifeyraasqk
       61 ltvtivraqg lpdkdrsgvn swqvhvvllp gkkhrgrtni qrgpnpvfre kvtfaklepr
      121 dvaacavrfr lyaarkmtre rmmgeklfyl shlhpegemk vtlvleprsn issggsplsp
      181 savshsdsts stqslshgga pellvglsyn attgrlsvem ikgshfrnla vnrapdtygk
      241 lfllnsvgqe msrcktsirr gqpnpvyket fvfqvalfql sdvtlmisvy nrrtmkrkem
      301 igwialgqns sgeeeqdhwe emketkgqqi crwhtlles
//
LOCUS       XP_024305498             339 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-16 isoform X7 [Homo sapiens].
ACCESSION   XP_024305498
VERSION     XP_024305498.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449730.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..339
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..339
                     /product="synaptotagmin-16 isoform X7"
                     /calculated_mol_wt=37944
     Region          44..167
                     /region_name="C2A_Synaptotagmin-14_16"
                     /note="C2A domain first repeat present in Synaptotagmins
                     14 and 16; cd08389"
                     /db_xref="CDD:176035"
     Region          200..337
                     /region_name="C2B_Synaptotagmin-14_16"
                     /note="C2 domain second repeat present in Synaptotagmins
                     14 and 16; cd08408"
                     /db_xref="CDD:176053"
     CDS             1..339
                     /gene="SYT16"
                     /gene_synonym="CHR14SYT; Strep14; SYT14L; syt14r"
                     /coded_by="XM_024449730.2:4776..5795"
                     /db_xref="GeneID:83851"
                     /db_xref="HGNC:HGNC:23142"
                     /db_xref="MIM:610950"
ORIGIN      
        1 metafnsrgf edsyatdsss mwspeeqdrt nlqvpsgvse piskcgdldv ifeyraasqk
       61 ltvtivraqg lpdkdrsgvn swqvhvvllp gkkhrgrtni qrgpnpvfre kvtfaklepr
      121 dvaacavrfr lyaarkmtre rmmgeklfyl shlhpegemk vtlvleprsn issggsplsp
      181 savshsdsts stqslshgga pellvglsyn attgrlsvem ikgshfrnla vnrapdtygk
      241 lfllnsvgqe msrcktsirr gqpnpvyket fvfqvalfql sdvtlmisvy nrrtmkrkem
      301 igwialgqns sgeeeqdhwe emketkgqqi crwhtlles
//
LOCUS       XP_011535533             594 aa            linear   PRI 05-AUG-2025
DEFINITION  actin-histidine N-methyltransferase isoform X1 [Homo sapiens].
ACCESSION   XP_011535533
VERSION     XP_011535533.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537231.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Jun 6, 2016 this sequence version replaced XP_011535533.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..594
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..594
                     /product="actin-histidine N-methyltransferase isoform X1"
                     /calculated_mol_wt=67126
     Region          80..329
                     /region_name="SET_SETD3"
                     /note="SET domain found in SET domain-containing protein 3
                     (SETD3) and similar proteins; cd19176"
                     /db_xref="CDD:380953"
     Site            order(104,106,180,253..254,275..279,313,325,327,329)
                     /site_type="other"
                     /note="SAM binding site"
                     /db_xref="CDD:380953"
     Site            order(105..106,123,251..256,275..279,286,311..314)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:380953"
     Region          344..475
                     /region_name="Rubis-subs-bind"
                     /note="Rubisco LSMT substrate-binding; pfam09273"
                     /db_xref="CDD:462737"
     CDS             1..594
                     /gene="SETD3"
                     /gene_synonym="C14orf154; hSETD3"
                     /coded_by="XM_011537231.3:123..1907"
                     /db_xref="GeneID:84193"
                     /db_xref="HGNC:HGNC:20493"
                     /db_xref="MIM:615671"
ORIGIN      
        1 mgkksrvktq ksgtgatatv spkeilnlts ellqkcsspa pgpgkeweey vqirtlveki
       61 rkkqkglsvt fdgkredyfp dlmkwaseng asvegfemvn fkeegfglra trdikaeelf
      121 lwvprkllmt vesaknsvlg plysqdrilq amgnialafh llceraspns fwqpyiqtlp
      181 seydtplyfe edevrylqst qaihdvfsqy kntarqyayf ykviqthpha nklplkdsft
      241 yedyrwavss vmtrqnqipt edgsrvtlal iplwdmcnht nglittgynl eddrcecval
      301 qdfrageqiy ifygtrsnae fvihsgfffd nnshdrvkik lgvsksdrly amkaevlara
      361 giptssvfal hfteppisaq llaflrvfcm teeelkehll gdsaidrift lgnsefpvsw
      421 dnevklwtfl edraslllkt ykttieedks vlknhdlsvr akmaiklrlg ekeilekavk
      481 saavnreyyr qqmeekaplp kyeesnlgll essvgdsrlp lvlrnleeea gvqdalnire
      541 aiskakaten glvngensip ngtrsenesl nqeskraved akgsssdsta gvke
//
LOCUS       XP_016877188             594 aa            linear   PRI 05-AUG-2025
DEFINITION  actin-histidine N-methyltransferase isoform X1 [Homo sapiens].
ACCESSION   XP_016877188
VERSION     XP_016877188.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021699.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..594
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..594
                     /product="actin-histidine N-methyltransferase isoform X1"
                     /calculated_mol_wt=67126
     Region          80..329
                     /region_name="SET_SETD3"
                     /note="SET domain found in SET domain-containing protein 3
                     (SETD3) and similar proteins; cd19176"
                     /db_xref="CDD:380953"
     Site            order(104,106,180,253..254,275..279,313,325,327,329)
                     /site_type="other"
                     /note="SAM binding site"
                     /db_xref="CDD:380953"
     Site            order(105..106,123,251..256,275..279,286,311..314)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:380953"
     Region          344..475
                     /region_name="Rubis-subs-bind"
                     /note="Rubisco LSMT substrate-binding; pfam09273"
                     /db_xref="CDD:462737"
     CDS             1..594
                     /gene="SETD3"
                     /gene_synonym="C14orf154; hSETD3"
                     /coded_by="XM_017021699.2:19..1803"
                     /db_xref="GeneID:84193"
                     /db_xref="HGNC:HGNC:20493"
                     /db_xref="MIM:615671"
ORIGIN      
        1 mgkksrvktq ksgtgatatv spkeilnlts ellqkcsspa pgpgkeweey vqirtlveki
       61 rkkqkglsvt fdgkredyfp dlmkwaseng asvegfemvn fkeegfglra trdikaeelf
      121 lwvprkllmt vesaknsvlg plysqdrilq amgnialafh llceraspns fwqpyiqtlp
      181 seydtplyfe edevrylqst qaihdvfsqy kntarqyayf ykviqthpha nklplkdsft
      241 yedyrwavss vmtrqnqipt edgsrvtlal iplwdmcnht nglittgynl eddrcecval
      301 qdfrageqiy ifygtrsnae fvihsgfffd nnshdrvkik lgvsksdrly amkaevlara
      361 giptssvfal hfteppisaq llaflrvfcm teeelkehll gdsaidrift lgnsefpvsw
      421 dnevklwtfl edraslllkt ykttieedks vlknhdlsvr akmaiklrlg ekeilekavk
      481 saavnreyyr qqmeekaplp kyeesnlgll essvgdsrlp lvlrnleeea gvqdalnire
      541 aiskakaten glvngensip ngtrsenesl nqeskraved akgsssdsta gvke
//
LOCUS       XP_011535534             594 aa            linear   PRI 05-AUG-2025
DEFINITION  actin-histidine N-methyltransferase isoform X1 [Homo sapiens].
ACCESSION   XP_011535534
VERSION     XP_011535534.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537232.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..594
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..594
                     /product="actin-histidine N-methyltransferase isoform X1"
                     /calculated_mol_wt=67126
     Region          80..329
                     /region_name="SET_SETD3"
                     /note="SET domain found in SET domain-containing protein 3
                     (SETD3) and similar proteins; cd19176"
                     /db_xref="CDD:380953"
     Site            order(104,106,180,253..254,275..279,313,325,327,329)
                     /site_type="other"
                     /note="SAM binding site"
                     /db_xref="CDD:380953"
     Site            order(105..106,123,251..256,275..279,286,311..314)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:380953"
     Region          344..475
                     /region_name="Rubis-subs-bind"
                     /note="Rubisco LSMT substrate-binding; pfam09273"
                     /db_xref="CDD:462737"
     CDS             1..594
                     /gene="SETD3"
                     /gene_synonym="C14orf154; hSETD3"
                     /coded_by="XM_011537232.4:65..1849"
                     /db_xref="GeneID:84193"
                     /db_xref="HGNC:HGNC:20493"
                     /db_xref="MIM:615671"
ORIGIN      
        1 mgkksrvktq ksgtgatatv spkeilnlts ellqkcsspa pgpgkeweey vqirtlveki
       61 rkkqkglsvt fdgkredyfp dlmkwaseng asvegfemvn fkeegfglra trdikaeelf
      121 lwvprkllmt vesaknsvlg plysqdrilq amgnialafh llceraspns fwqpyiqtlp
      181 seydtplyfe edevrylqst qaihdvfsqy kntarqyayf ykviqthpha nklplkdsft
      241 yedyrwavss vmtrqnqipt edgsrvtlal iplwdmcnht nglittgynl eddrcecval
      301 qdfrageqiy ifygtrsnae fvihsgfffd nnshdrvkik lgvsksdrly amkaevlara
      361 giptssvfal hfteppisaq llaflrvfcm teeelkehll gdsaidrift lgnsefpvsw
      421 dnevklwtfl edraslllkt ykttieedks vlknhdlsvr akmaiklrlg ekeilekavk
      481 saavnreyyr qqmeekaplp kyeesnlgll essvgdsrlp lvlrnleeea gvqdalnire
      541 aiskakaten glvngensip ngtrsenesl nqeskraved akgsssdsta gvke
//
LOCUS       XP_047287761             594 aa            linear   PRI 05-AUG-2025
DEFINITION  actin-histidine N-methyltransferase isoform X1 [Homo sapiens].
ACCESSION   XP_047287761
VERSION     XP_047287761.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431805.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..594
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..594
                     /product="actin-histidine N-methyltransferase isoform X1"
                     /calculated_mol_wt=67126
     Region          80..329
                     /region_name="SET_SETD3"
                     /note="SET domain found in SET domain-containing protein 3
                     (SETD3) and similar proteins; cd19176"
                     /db_xref="CDD:380953"
     Site            order(104,106,180,253..254,275..279,313,325,327,329)
                     /site_type="other"
                     /note="SAM binding site"
                     /db_xref="CDD:380953"
     Site            order(105..106,123,251..256,275..279,286,311..314)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:380953"
     Region          344..475
                     /region_name="Rubis-subs-bind"
                     /note="Rubisco LSMT substrate-binding; pfam09273"
                     /db_xref="CDD:462737"
     CDS             1..594
                     /gene="SETD3"
                     /gene_synonym="C14orf154; hSETD3"
                     /coded_by="XM_047431805.1:139..1923"
                     /db_xref="GeneID:84193"
                     /db_xref="HGNC:HGNC:20493"
                     /db_xref="MIM:615671"
ORIGIN      
        1 mgkksrvktq ksgtgatatv spkeilnlts ellqkcsspa pgpgkeweey vqirtlveki
       61 rkkqkglsvt fdgkredyfp dlmkwaseng asvegfemvn fkeegfglra trdikaeelf
      121 lwvprkllmt vesaknsvlg plysqdrilq amgnialafh llceraspns fwqpyiqtlp
      181 seydtplyfe edevrylqst qaihdvfsqy kntarqyayf ykviqthpha nklplkdsft
      241 yedyrwavss vmtrqnqipt edgsrvtlal iplwdmcnht nglittgynl eddrcecval
      301 qdfrageqiy ifygtrsnae fvihsgfffd nnshdrvkik lgvsksdrly amkaevlara
      361 giptssvfal hfteppisaq llaflrvfcm teeelkehll gdsaidrift lgnsefpvsw
      421 dnevklwtfl edraslllkt ykttieedks vlknhdlsvr akmaiklrlg ekeilekavk
      481 saavnreyyr qqmeekaplp kyeesnlgll essvgdsrlp lvlrnleeea gvqdalnire
      541 aiskakaten glvngensip ngtrsenesl nqeskraved akgsssdsta gvke
//
LOCUS       XP_016877189             594 aa            linear   PRI 05-AUG-2025
DEFINITION  actin-histidine N-methyltransferase isoform X1 [Homo sapiens].
ACCESSION   XP_016877189
VERSION     XP_016877189.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021700.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..594
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..594
                     /product="actin-histidine N-methyltransferase isoform X1"
                     /calculated_mol_wt=67126
     Region          80..329
                     /region_name="SET_SETD3"
                     /note="SET domain found in SET domain-containing protein 3
                     (SETD3) and similar proteins; cd19176"
                     /db_xref="CDD:380953"
     Site            order(104,106,180,253..254,275..279,313,325,327,329)
                     /site_type="other"
                     /note="SAM binding site"
                     /db_xref="CDD:380953"
     Site            order(105..106,123,251..256,275..279,286,311..314)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:380953"
     Region          344..475
                     /region_name="Rubis-subs-bind"
                     /note="Rubisco LSMT substrate-binding; pfam09273"
                     /db_xref="CDD:462737"
     CDS             1..594
                     /gene="SETD3"
                     /gene_synonym="C14orf154; hSETD3"
                     /coded_by="XM_017021700.2:197..1981"
                     /db_xref="GeneID:84193"
                     /db_xref="HGNC:HGNC:20493"
                     /db_xref="MIM:615671"
ORIGIN      
        1 mgkksrvktq ksgtgatatv spkeilnlts ellqkcsspa pgpgkeweey vqirtlveki
       61 rkkqkglsvt fdgkredyfp dlmkwaseng asvegfemvn fkeegfglra trdikaeelf
      121 lwvprkllmt vesaknsvlg plysqdrilq amgnialafh llceraspns fwqpyiqtlp
      181 seydtplyfe edevrylqst qaihdvfsqy kntarqyayf ykviqthpha nklplkdsft
      241 yedyrwavss vmtrqnqipt edgsrvtlal iplwdmcnht nglittgynl eddrcecval
      301 qdfrageqiy ifygtrsnae fvihsgfffd nnshdrvkik lgvsksdrly amkaevlara
      361 giptssvfal hfteppisaq llaflrvfcm teeelkehll gdsaidrift lgnsefpvsw
      421 dnevklwtfl edraslllkt ykttieedks vlknhdlsvr akmaiklrlg ekeilekavk
      481 saavnreyyr qqmeekaplp kyeesnlgll essvgdsrlp lvlrnleeea gvqdalnire
      541 aiskakaten glvngensip ngtrsenesl nqeskraved akgsssdsta gvke
//
LOCUS       XP_011535535             536 aa            linear   PRI 05-AUG-2025
DEFINITION  actin-histidine N-methyltransferase isoform X2 [Homo sapiens].
ACCESSION   XP_011535535
VERSION     XP_011535535.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537233.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..536
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..536
                     /product="actin-histidine N-methyltransferase isoform X2"
                     /calculated_mol_wt=60474
     Region          80..271
                     /region_name="SET_SETD3"
                     /note="SET domain found in SET domain-containing protein 3
                     (SETD3) and similar proteins; cd19176"
                     /db_xref="CDD:380953"
     Region          286..417
                     /region_name="Rubis-subs-bind"
                     /note="Rubisco LSMT substrate-binding; pfam09273"
                     /db_xref="CDD:462737"
     CDS             1..536
                     /gene="SETD3"
                     /gene_synonym="C14orf154; hSETD3"
                     /coded_by="XM_011537233.3:123..1733"
                     /db_xref="GeneID:84193"
                     /db_xref="HGNC:HGNC:20493"
                     /db_xref="MIM:615671"
ORIGIN      
        1 mgkksrvktq ksgtgatatv spkeilnlts ellqkcsspa pgpgkeweey vqirtlveki
       61 rkkqkglsvt fdgkredyfp dlmkwaseng asvegfemvn fkeegfglra trdikaeelf
      121 lwvprkllmt vesaknsvlg plysqdrilq amgnialafh llceraspns fwqpyiqtlp
      181 seydtplyfe edevrylqst qaihdvfsqy kntarqyayf ykviqittgy nleddrcecv
      241 alqdfrageq iyifygtrsn aefvihsgff fdnnshdrvk iklgvsksdr lyamkaevla
      301 ragiptssvf alhfteppis aqllaflrvf cmteeelkeh llgdsaidri ftlgnsefpv
      361 swdnevklwt fledraslll ktykttieed ksvlknhdls vrakmaiklr lgekeileka
      421 vksaavnrey yrqqmeekap lpkyeesnlg llessvgdsr lplvlrnlee eagvqdalni
      481 reaiskakat englvngens ipngtrsene slnqeskrav edakgsssds tagvke
//
LOCUS       XP_011535537             296 aa            linear   PRI 05-AUG-2025
DEFINITION  actin-histidine N-methyltransferase isoform X3 [Homo sapiens].
ACCESSION   XP_011535537
VERSION     XP_011535537.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537235.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..296
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..296
                     /product="actin-histidine N-methyltransferase isoform X3"
                     /calculated_mol_wt=33570
     Region          80..282
                     /region_name="SET_SETD3"
                     /note="SET domain found in SET domain-containing protein 3
                     (SETD3) and similar proteins; cd19176"
                     /db_xref="CDD:380953"
     CDS             1..296
                     /gene="SETD3"
                     /gene_synonym="C14orf154; hSETD3"
                     /coded_by="XM_011537235.1:123..1013"
                     /db_xref="GeneID:84193"
                     /db_xref="HGNC:HGNC:20493"
                     /db_xref="MIM:615671"
ORIGIN      
        1 mgkksrvktq ksgtgatatv spkeilnlts ellqkcsspa pgpgkeweey vqirtlveki
       61 rkkqkglsvt fdgkredyfp dlmkwaseng asvegfemvn fkeegfglra trdikaeelf
      121 lwvprkllmt vesaknsvlg plysqdrilq amgnialafh llceraspns fwqpyiqtlp
      181 seydtplyfe edevrylqst qaihdvfsqy kntarqyayf ykviqthpha nklplkdsft
      241 yedyrwavss vmtrqnqipt edgsrvtlal iplwdmcnht ngltpedsfa lavasa
//
LOCUS       XP_005268185             330 aa            linear   PRI 05-AUG-2025
DEFINITION  breast cancer metastasis-suppressor 1-like protein isoform X1 [Homo
            sapiens].
ACCESSION   XP_005268185
VERSION     XP_005268185.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005268128.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..330
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..330
                     /product="breast cancer metastasis-suppressor 1-like
                     protein isoform X1"
                     /calculated_mol_wt=38298
     Region          61..>177
                     /region_name="Sds3"
                     /note="Sds3-like; pfam08598"
                     /db_xref="CDD:430099"
     CDS             1..330
                     /gene="BRMS1L"
                     /gene_synonym="BRMS1; p40"
                     /coded_by="XM_005268128.2:180..1172"
                     /db_xref="GeneID:84312"
                     /db_xref="HGNC:HGNC:20512"
                     /db_xref="MIM:618514"
ORIGIN      
        1 mpvhsrgdkk etnhhdemev dyaenegsss ededtesssv sedgdssemd dedcerrrme
       61 cldemsnlek qftdlkdqly kerlsqvdak lqeviagkap eyleplatlq enmqirtkva
      121 giyrelcles vknkyeceiq asrqhcesek lllydtvqse leekirrlee drhsiditse
      181 lwndelqsrk krkdpfspdk kkpvvvsgpy ivymlqdldi ledwttirka matlgphrvk
      241 telfelipla pvklekhlhs arseegrlyy dgewyirgqt icidkkdecp tsavittinh
      301 devwfkrpdg sksklyisql qkgkysikhs
//
LOCUS       XP_047287762             282 aa            linear   PRI 05-AUG-2025
DEFINITION  breast cancer metastasis-suppressor 1-like protein isoform X2 [Homo
            sapiens].
ACCESSION   XP_047287762
VERSION     XP_047287762.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431806.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 27% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..282
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..282
                     /product="breast cancer metastasis-suppressor 1-like
                     protein isoform X2"
                     /calculated_mol_wt=33014
     Region          13..>129
                     /region_name="Sds3"
                     /note="Sds3-like; pfam08598"
                     /db_xref="CDD:430099"
     CDS             1..282
                     /gene="BRMS1L"
                     /gene_synonym="BRMS1; p40"
                     /coded_by="XM_047431806.1:537..1385"
                     /db_xref="GeneID:84312"
                     /db_xref="HGNC:HGNC:20512"
                     /db_xref="MIM:618514"
ORIGIN      
        1 mddedcerrr mecldemsnl ekqftdlkdq lykerlsqvd aklqeviagk apeyleplat
       61 lqenmqirtk vagiyrelcl esvknkyece iqasrqhces eklllydtvq seleekirrl
      121 eedrhsidit selwndelqs rkkrkdpfsp dkkkpvvvsg pyivymlqdl diledwttir
      181 kamatlgphr vktelfelip lapvklekhl hsarseegrl yydgewyirg qticidkkde
      241 cptsavitti nhdevwfkrp dgsksklyis qlqkgkysik hs
//
LOCUS       XP_016877194             275 aa            linear   PRI 05-AUG-2025
DEFINITION  breast cancer metastasis-suppressor 1-like protein isoform X3 [Homo
            sapiens].
ACCESSION   XP_016877194
VERSION     XP_016877194.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021705.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..275
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..275
                     /product="breast cancer metastasis-suppressor 1-like
                     protein isoform X3"
                     /calculated_mol_wt=32214
     Region          13..>129
                     /region_name="Sds3"
                     /note="Sds3-like; pfam08598"
                     /db_xref="CDD:430099"
     CDS             1..275
                     /gene="BRMS1L"
                     /gene_synonym="BRMS1; p40"
                     /coded_by="XM_017021705.1:168..995"
                     /db_xref="GeneID:84312"
                     /db_xref="HGNC:HGNC:20512"
                     /db_xref="MIM:618514"
ORIGIN      
        1 mddedcerrr mecldemsnl ekqftdlkdq lykerlsqvd aklqeviagk apeyleplat
       61 lqenmqirtk vagiyrelcl esvknkyece iqasrqhces eklllydtvq seleekirrl
      121 eedrhsidit selwndelqs rkkrkdpfsp dkkkpvvvsg pyivymlqdl diledwttir
      181 kamatlgphr vkteppvkle khlhsarsee grlyydgewy irgqticidk kdecptsavi
      241 ttinhdevwf krpdgskskl yisqlqkgky sikhs
//
LOCUS       XP_011535538             717 aa            linear   PRI 05-AUG-2025
DEFINITION  HHIP-like protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_011535538
VERSION     XP_011535538.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537236.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..717
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..717
                     /product="HHIP-like protein 1 isoform X1"
                     /calculated_mol_wt=79334
     Region          <20..118
                     /region_name="Folate_rec"
                     /note="Folate receptor family; pfam03024"
                     /db_xref="CDD:397250"
     Region          119..507
                     /region_name="YliI"
                     /note="Glucose/arabinose dehydrogenase, beta-propeller
                     fold [Carbohydrate transport and metabolism]; COG2133"
                     /db_xref="CDD:441736"
     Region          608..711
                     /region_name="SR"
                     /note="Scavenger receptor Cys-rich; smart00202"
                     /db_xref="CDD:214555"
     CDS             1..717
                     /gene="HHIPL1"
                     /gene_synonym="KIAA1822; UNQ9245"
                     /coded_by="XM_011537236.3:365..2518"
                     /db_xref="GeneID:84439"
                     /db_xref="HGNC:HGNC:19710"
ORIGIN      
        1 mtgkgcsrrn lsswvplggq ecspyaahly daedpftplr tvpglcqdyc ldmwhkcrgl
       61 frhlstdqel walegnlarf crylslddtd ycfpyllvnk nlnsnlghvv adakgclqlc
      121 leevanglrn pvamvhardg thrffvaeqv glvwaylpdr srlgkpflni srvvltspwe
      181 gdergflgia fhpsfqhnrr lyvyysvgir ssewirisef rvseddenav dhsseriile
      241 vkepasnhng gqllfgddgy lyiftgdggm agdpfgtfgn aqnksallgk vlridvdrke
      301 rglpygippd npfvgdpaaq pevyalgvrn mwrcsfdrgd pssgtgrgrl fcgdvgqnkf
      361 eevdvvergg nygwraregf ecydrslcan tslndllpif ayphtvgksv tggyvyrgce
      421 ypnlnglyif gdfmsgrlms lqenpgtgqw qyseicmghg qtcefpglin nyypyiisfg
      481 edeagelyfm stgepsatap rgvvykiida srrappgkcq iqpaqvkirs rlipfvpkek
      541 fipktrstpr ptaraptrap rrgrptaapp aptprparpt qqpgsrrggg rrrgrlnsas
      601 rafrdgevrl vrpaglssgs grvevfvggr wgtvcddswn isgaavvcrq lgfayavrav
      661 kraefgqggs lpillddvrc agwernllec qhngvgthnc ehdedagvvc shqnpdl
//
LOCUS       XP_006720340             707 aa            linear   PRI 05-AUG-2025
DEFINITION  HHIP-like protein 1 isoform X2 [Homo sapiens].
ACCESSION   XP_006720340
VERSION     XP_006720340.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720277.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..707
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..707
                     /product="HHIP-like protein 1 isoform X2"
                     /calculated_mol_wt=78347
     Region          <11..108
                     /region_name="Folate_rec"
                     /note="Folate receptor family; pfam03024"
                     /db_xref="CDD:397250"
     Region          109..497
                     /region_name="YliI"
                     /note="Glucose/arabinose dehydrogenase, beta-propeller
                     fold [Carbohydrate transport and metabolism]; COG2133"
                     /db_xref="CDD:441736"
     Region          598..701
                     /region_name="SR"
                     /note="Scavenger receptor Cys-rich; smart00202"
                     /db_xref="CDD:214555"
     CDS             1..707
                     /gene="HHIPL1"
                     /gene_synonym="KIAA1822; UNQ9245"
                     /coded_by="XM_006720277.4:277..2400"
                     /db_xref="GeneID:84439"
                     /db_xref="HGNC:HGNC:19710"
ORIGIN      
        1 mkiarclpse ecspyaahly daedpftplr tvpglcqdyc ldmwhkcrgl frhlstdqel
       61 walegnlarf crylslddtd ycfpyllvnk nlnsnlghvv adakgclqlc leevanglrn
      121 pvamvhardg thrffvaeqv glvwaylpdr srlgkpflni srvvltspwe gdergflgia
      181 fhpsfqhnrr lyvyysvgir ssewirisef rvseddenav dhsseriile vkepasnhng
      241 gqllfgddgy lyiftgdggm agdpfgtfgn aqnksallgk vlridvdrke rglpygippd
      301 npfvgdpaaq pevyalgvrn mwrcsfdrgd pssgtgrgrl fcgdvgqnkf eevdvvergg
      361 nygwraregf ecydrslcan tslndllpif ayphtvgksv tggyvyrgce ypnlnglyif
      421 gdfmsgrlms lqenpgtgqw qyseicmghg qtcefpglin nyypyiisfg edeagelyfm
      481 stgepsatap rgvvykiida srrappgkcq iqpaqvkirs rlipfvpkek fipktrstpr
      541 ptaraptrap rrgrptaapp aptprparpt qqpgsrrggg rrrgrlnsas rafrdgevrl
      601 vrpaglssgs grvevfvggr wgtvcddswn isgaavvcrq lgfayavrav kraefgqggs
      661 lpillddvrc agwernllec qhngvgthnc ehdedagvvc shqnpdl
//
LOCUS       XP_016877196             665 aa            linear   PRI 05-AUG-2025
DEFINITION  HHIP-like protein 1 isoform X3 [Homo sapiens].
ACCESSION   XP_016877196
VERSION     XP_016877196.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021707.3
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 9% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..665
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..665
                     /product="HHIP-like protein 1 isoform X3"
                     /calculated_mol_wt=73631
     Region          67..455
                     /region_name="YliI"
                     /note="Glucose/arabinose dehydrogenase, beta-propeller
                     fold [Carbohydrate transport and metabolism]; COG2133"
                     /db_xref="CDD:441736"
     Region          556..659
                     /region_name="SR"
                     /note="Scavenger receptor Cys-rich; smart00202"
                     /db_xref="CDD:214555"
     CDS             1..665
                     /gene="HHIPL1"
                     /gene_synonym="KIAA1822; UNQ9245"
                     /coded_by="XM_017021707.3:617..2614"
                     /db_xref="GeneID:84439"
                     /db_xref="HGNC:HGNC:19710"
ORIGIN      
        1 mwhkcrglfr hlstdqelwa legnlarfcr ylslddtdyc fpyllvnknl nsnlghvvad
       61 akgclqlcle evanglrnpv amvhardgth rffvaeqvgl vwaylpdrsr lgkpflnisr
      121 vvltspwegd ergflgiafh psfqhnrrly vyysvgirss ewirisefrv seddenavdh
      181 sseriilevk epasnhnggq llfgddgyly iftgdggmag dpfgtfgnaq nksallgkvl
      241 ridvdrkerg lpygippdnp fvgdpaaqpe vyalgvrnmw rcsfdrgdps sgtgrgrlfc
      301 gdvgqnkfee vdvverggny gwraregfec ydrslcants lndllpifay phtvgksvtg
      361 gyvyrgceyp nlnglyifgd fmsgrlmslq enpgtgqwqy seicmghgqt cefpglinny
      421 ypyiisfged eagelyfmst gepsataprg vvykiidasr rappgkcqiq paqvkirsrl
      481 ipfvpkekfi pktrstprpt araptraprr grptaappap tprparptqq pgsrrgggrr
      541 rgrlnsasra frdgevrlvr paglssgsgr vevfvggrwg tvcddswnis gaavvcrqlg
      601 fayavravkr aefgqggslp illddvrcag wernllecqh ngvgthnceh dedagvvcsh
      661 qnpdl
//
LOCUS       XP_011535539             593 aa            linear   PRI 05-AUG-2025
DEFINITION  HHIP-like protein 1 isoform X4 [Homo sapiens].
ACCESSION   XP_011535539
VERSION     XP_011535539.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537237.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..593
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..593
                     /product="HHIP-like protein 1 isoform X4"
                     /calculated_mol_wt=66063
     Region          22..183
                     /region_name="Folate_rec"
                     /note="Folate receptor family; pfam03024"
                     /db_xref="CDD:397250"
     Region          184..572
                     /region_name="YliI"
                     /note="Glucose/arabinose dehydrogenase, beta-propeller
                     fold [Carbohydrate transport and metabolism]; COG2133"
                     /db_xref="CDD:441736"
     CDS             1..593
                     /gene="HHIPL1"
                     /gene_synonym="KIAA1822; UNQ9245"
                     /coded_by="XM_011537237.3:99..1880"
                     /db_xref="GeneID:84439"
                     /db_xref="HGNC:HGNC:19710"
ORIGIN      
        1 mararagall alwvlgaaah pqcldfrppf rptqplrlca qysdfgccde grdaeltrrf
       61 walasrvdaa ewaacagyar dllcqecspy aahlydaedp ftplrtvpgl cqdycldmwh
      121 kcrglfrhls tdqelwaleg nlarfcryls lddtdycfpy llvnknlnsn lghvvadakg
      181 clqlcleeva nglrnpvamv hardgthrff vaeqvglvwa ylpdrsrlgk pflnisrvvl
      241 tspwegderg flgiafhpsf qhnrrlyvyy svgirssewi risefrvsed denavdhsse
      301 riilevkepa snhnggqllf gddgylyift gdggmagdpf gtfgnaqnks allgkvlrid
      361 vdrkerglpy gippdnpfvg dpaaqpevya lgvrnmwrcs fdrgdpssgt grgrlfcgdv
      421 gqnkfeevdv verggnygwr aregfecydr slcantslnd llpifaypht vgksvtggyv
      481 yrgceypnln glyifgdfms grlmslqenp gtgqwqysei cmghgqtcef pglinnyypy
      541 iisfgedeag elyfmstgep sataprgvvy kiidasrgrp gagngteqrl rnt
//
LOCUS       XP_016877198             224 aa            linear   PRI 05-AUG-2025
DEFINITION  gem-associated protein 2 isoform X1 [Homo sapiens].
ACCESSION   XP_016877198
VERSION     XP_016877198.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021709.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XP_016877198.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..224
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..224
                     /product="gem-associated protein 2 isoform X1"
                     /calculated_mol_wt=25143
     Region          34..219
                     /region_name="SIP1"
                     /note="Survival motor neuron (SMN) interacting protein 1
                     (SIP1); pfam04938"
                     /db_xref="CDD:461493"
     CDS             1..224
                     /gene="GEMIN2"
                     /gene_synonym="SIP1; SIP1-delta"
                     /coded_by="XM_017021709.2:17..691"
                     /db_xref="GeneID:8487"
                     /db_xref="HGNC:HGNC:10884"
                     /db_xref="MIM:602595"
ORIGIN      
        1 mawvpaesav eelmprllpv epcdltegfd psvpprtpqe ylrrvqieaa qcpdvvvaqi
       61 dpkklkrkqs vnislsgcqp apegysptlq wqqqqvaqfs tvrqnvnkhr shwksqqlds
      121 nvtmpksede egwkkfclge klcadgavgp atnespgidy vqatvtsvle ylsnwfgerd
      181 ftpelgrwly allaclekpl lpeahslirq larrcsevrl lvvf
//
LOCUS       XP_047287763             146 aa            linear   PRI 05-AUG-2025
DEFINITION  gem-associated protein 2 isoform X2 [Homo sapiens].
ACCESSION   XP_047287763
VERSION     XP_047287763.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431807.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..146
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..146
                     /product="gem-associated protein 2 isoform X2"
                     /calculated_mol_wt=16327
     Region          <1..139
                     /region_name="SIP1"
                     /note="Survival motor neuron (SMN) interacting protein 1
                     (SIP1); pfam04938"
                     /db_xref="CDD:461493"
     CDS             1..146
                     /gene="GEMIN2"
                     /gene_synonym="SIP1; SIP1-delta"
                     /coded_by="XM_047431807.1:325..765"
                     /db_xref="GeneID:8487"
                     /db_xref="HGNC:HGNC:10884"
                     /db_xref="MIM:602595"
ORIGIN      
        1 mpksedeegw kkfclgeklc adgavgpatn espgidyvqi gfppllsivs rmnqatvtsv
       61 leylsnwfge rdftpelgrw lyallaclek pllpeahsli rqlarrcsev rllvdskdde
      121 rvpalnllic lvsryfdqrd ladeps
//
LOCUS       XP_047287765             171 aa            linear   PRI 05-AUG-2025
DEFINITION  ras-related protein Rab-2B isoform X1 [Homo sapiens].
ACCESSION   XP_047287765
VERSION     XP_047287765.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431809.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..171
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..171
                     /product="ras-related protein Rab-2B isoform X1"
                     /calculated_mol_wt=18883
     Region          <18..171
                     /region_name="PLN03108"
                     /note="Rab family protein; Provisional"
                     /db_xref="CDD:178655"
     CDS             1..171
                     /gene="RAB2B"
                     /coded_by="XM_047431809.1:88..603"
                     /db_xref="GeneID:84932"
                     /db_xref="HGNC:HGNC:20246"
                     /db_xref="MIM:607466"
ORIGIN      
        1 myanvfivfi vltgvpqagq esfrsitrsy yrgaagallv yditrretfn hltswledar
       61 qhsssnmvim lignksdles rrdvkreege afarehglif metsaktacn veeafintak
      121 eiyrkiqqgl fdvhneangi kigpqqsist svgpsasqrn srdigsnsgc c
//
LOCUS       XP_016877201             147 aa            linear   PRI 05-AUG-2025
DEFINITION  ras-related protein Rab-2B isoform X2 [Homo sapiens].
ACCESSION   XP_016877201
VERSION     XP_016877201.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021712.2
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 11% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..147
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..147
                     /product="ras-related protein Rab-2B isoform X2"
                     /calculated_mol_wt=16174
     Region          <9..147
                     /region_name="PLN03108"
                     /note="Rab family protein; Provisional"
                     /db_xref="CDD:178655"
     CDS             1..147
                     /gene="RAB2B"
                     /coded_by="XM_017021712.2:149..592"
                     /db_xref="GeneID:84932"
                     /db_xref="HGNC:HGNC:20246"
                     /db_xref="MIM:607466"
ORIGIN      
        1 mgterliwga agallvydit rretfnhlts wledarqhss snmvimlign ksdlesrrdv
       61 kreegeafar ehglifmets aktacnveea fintakeiyr kiqqglfdvh neangikigp
      121 qqsistsvgp sasqrnsrdi gsnsgcc
//
LOCUS       XP_024305502             977 aa            linear   PRI 05-AUG-2025
DEFINITION  stonin-2 isoform X1 [Homo sapiens].
ACCESSION   XP_024305502
VERSION     XP_024305502.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449734.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..977
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..977
                     /product="stonin-2 isoform X1"
                     /calculated_mol_wt=108835
     Region          1..397
                     /region_name="Stonin2_N"
                     /note="Stonin 2; pfam12016"
                     /db_xref="CDD:403289"
     Region          616..928
                     /region_name="AP_stonin-2_MHD"
                     /note="Mu homology domain (MHD) of adaptor-like protein
                     (AP-like), stonin-2; cd09263"
                     /db_xref="CDD:271169"
     CDS             1..977
                     /gene="STON2"
                     /gene_synonym="STN2; STNB; STNB2"
                     /coded_by="XM_024449734.2:785..3718"
                     /db_xref="GeneID:85439"
                     /db_xref="HGNC:HGNC:30652"
                     /db_xref="MIM:608467"
ORIGIN      
        1 mttldhviat hqsewvsfne eppfpahsqg gteehlpgls sspdqsesss genhvvdggs
       61 qdhshseqdd ssekmglise aasppgspeq pppdlasais nwvqfeddtp wastspphqe
      121 taetalpltm pcwtcpsfds lgrcpltses swtthsedts spsfgcsytd lqlinaeeqt
      181 sgqasgadst dkrtewqtgr qtavspvqac sehtstrthr ldpsppspqp krsqnpgegp
      241 egasapndns sslqedeeve meaiswqass pamnghpapp vtsarfpswv tfddnevscp
      301 lppvtsplkp ntppsasvip dvpynsmgsf kkrdrpkstl mnfskvqkld isslnrtpsv
      361 teaspwratn pflnetlqdv qpspinpfsa ffeeqerrsq nssissttgk sqrdsliviy
      421 qdaisfddss ktqshsdave klkqlqiddp dhfgsatlpd ddpvawield ahppgsarsq
      481 prdgwpmmlr ipekknimss rhwgpifvkl tdtgylqlyy eqglekpfre fkleicheis
      541 eprlqnyden grihslridr vtykekkkyq pkpavahtae reqviklgtt nyddflsfih
      601 avqdrlmdlp vlsmdlstvg lnyleeeitv dvrdefsgiv skgdnqilqh hvltrihils
      661 flsglaecrl glndilvkgn eivlrqdimp ttttkwiklh ecrfhgcvde dvfhnsrvil
      721 fnpldacrfe lmrfrtvfae ktlpftlrta tsvngaevev qswlrmstgf sanrdpltqv
      781 pcenvmiryp vpsewvknfr resvlgeksl kakvnrgasf gstsvsgsep vmrvtlgtak
      841 yehafnsivw rinrlpdkns asghphcffc hlelgsdrev psrfanhvnv efsmpttsas
      901 kasvrsisve dktdvrkwvn ysahysyqtt etdnlpnply csclphtdlk rgskrvvkir
      961 wnaslevpla ssirtmv
//
LOCUS       XP_047287767             977 aa            linear   PRI 05-AUG-2025
DEFINITION  stonin-2 isoform X1 [Homo sapiens].
ACCESSION   XP_047287767
VERSION     XP_047287767.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431811.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..977
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..977
                     /product="stonin-2 isoform X1"
                     /calculated_mol_wt=108835
     Region          1..397
                     /region_name="Stonin2_N"
                     /note="Stonin 2; pfam12016"
                     /db_xref="CDD:403289"
     Region          616..928
                     /region_name="AP_stonin-2_MHD"
                     /note="Mu homology domain (MHD) of adaptor-like protein
                     (AP-like), stonin-2; cd09263"
                     /db_xref="CDD:271169"
     CDS             1..977
                     /gene="STON2"
                     /gene_synonym="STN2; STNB; STNB2"
                     /coded_by="XM_047431811.1:894..3827"
                     /db_xref="GeneID:85439"
                     /db_xref="HGNC:HGNC:30652"
                     /db_xref="MIM:608467"
ORIGIN      
        1 mttldhviat hqsewvsfne eppfpahsqg gteehlpgls sspdqsesss genhvvdggs
       61 qdhshseqdd ssekmglise aasppgspeq pppdlasais nwvqfeddtp wastspphqe
      121 taetalpltm pcwtcpsfds lgrcpltses swtthsedts spsfgcsytd lqlinaeeqt
      181 sgqasgadst dkrtewqtgr qtavspvqac sehtstrthr ldpsppspqp krsqnpgegp
      241 egasapndns sslqedeeve meaiswqass pamnghpapp vtsarfpswv tfddnevscp
      301 lppvtsplkp ntppsasvip dvpynsmgsf kkrdrpkstl mnfskvqkld isslnrtpsv
      361 teaspwratn pflnetlqdv qpspinpfsa ffeeqerrsq nssissttgk sqrdsliviy
      421 qdaisfddss ktqshsdave klkqlqiddp dhfgsatlpd ddpvawield ahppgsarsq
      481 prdgwpmmlr ipekknimss rhwgpifvkl tdtgylqlyy eqglekpfre fkleicheis
      541 eprlqnyden grihslridr vtykekkkyq pkpavahtae reqviklgtt nyddflsfih
      601 avqdrlmdlp vlsmdlstvg lnyleeeitv dvrdefsgiv skgdnqilqh hvltrihils
      661 flsglaecrl glndilvkgn eivlrqdimp ttttkwiklh ecrfhgcvde dvfhnsrvil
      721 fnpldacrfe lmrfrtvfae ktlpftlrta tsvngaevev qswlrmstgf sanrdpltqv
      781 pcenvmiryp vpsewvknfr resvlgeksl kakvnrgasf gstsvsgsep vmrvtlgtak
      841 yehafnsivw rinrlpdkns asghphcffc hlelgsdrev psrfanhvnv efsmpttsas
      901 kasvrsisve dktdvrkwvn ysahysyqtt etdnlpnply csclphtdlk rgskrvvkir
      961 wnaslevpla ssirtmv
//
LOCUS       XP_024305503             977 aa            linear   PRI 05-AUG-2025
DEFINITION  stonin-2 isoform X1 [Homo sapiens].
ACCESSION   XP_024305503
VERSION     XP_024305503.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449735.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..977
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..977
                     /product="stonin-2 isoform X1"
                     /calculated_mol_wt=108835
     Region          1..397
                     /region_name="Stonin2_N"
                     /note="Stonin 2; pfam12016"
                     /db_xref="CDD:403289"
     Region          616..928
                     /region_name="AP_stonin-2_MHD"
                     /note="Mu homology domain (MHD) of adaptor-like protein
                     (AP-like), stonin-2; cd09263"
                     /db_xref="CDD:271169"
     CDS             1..977
                     /gene="STON2"
                     /gene_synonym="STN2; STNB; STNB2"
                     /coded_by="XM_024449735.2:869..3802"
                     /db_xref="GeneID:85439"
                     /db_xref="HGNC:HGNC:30652"
                     /db_xref="MIM:608467"
ORIGIN      
        1 mttldhviat hqsewvsfne eppfpahsqg gteehlpgls sspdqsesss genhvvdggs
       61 qdhshseqdd ssekmglise aasppgspeq pppdlasais nwvqfeddtp wastspphqe
      121 taetalpltm pcwtcpsfds lgrcpltses swtthsedts spsfgcsytd lqlinaeeqt
      181 sgqasgadst dkrtewqtgr qtavspvqac sehtstrthr ldpsppspqp krsqnpgegp
      241 egasapndns sslqedeeve meaiswqass pamnghpapp vtsarfpswv tfddnevscp
      301 lppvtsplkp ntppsasvip dvpynsmgsf kkrdrpkstl mnfskvqkld isslnrtpsv
      361 teaspwratn pflnetlqdv qpspinpfsa ffeeqerrsq nssissttgk sqrdsliviy
      421 qdaisfddss ktqshsdave klkqlqiddp dhfgsatlpd ddpvawield ahppgsarsq
      481 prdgwpmmlr ipekknimss rhwgpifvkl tdtgylqlyy eqglekpfre fkleicheis
      541 eprlqnyden grihslridr vtykekkkyq pkpavahtae reqviklgtt nyddflsfih
      601 avqdrlmdlp vlsmdlstvg lnyleeeitv dvrdefsgiv skgdnqilqh hvltrihils
      661 flsglaecrl glndilvkgn eivlrqdimp ttttkwiklh ecrfhgcvde dvfhnsrvil
      721 fnpldacrfe lmrfrtvfae ktlpftlrta tsvngaevev qswlrmstgf sanrdpltqv
      781 pcenvmiryp vpsewvknfr resvlgeksl kakvnrgasf gstsvsgsep vmrvtlgtak
      841 yehafnsivw rinrlpdkns asghphcffc hlelgsdrev psrfanhvnv efsmpttsas
      901 kasvrsisve dktdvrkwvn ysahysyqtt etdnlpnply csclphtdlk rgskrvvkir
      961 wnaslevpla ssirtmv
//
LOCUS       XP_011535542             977 aa            linear   PRI 05-AUG-2025
DEFINITION  stonin-2 isoform X1 [Homo sapiens].
ACCESSION   XP_011535542
VERSION     XP_011535542.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537240.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..977
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..977
                     /product="stonin-2 isoform X1"
                     /calculated_mol_wt=108835
     Region          1..397
                     /region_name="Stonin2_N"
                     /note="Stonin 2; pfam12016"
                     /db_xref="CDD:403289"
     Region          616..928
                     /region_name="AP_stonin-2_MHD"
                     /note="Mu homology domain (MHD) of adaptor-like protein
                     (AP-like), stonin-2; cd09263"
                     /db_xref="CDD:271169"
     CDS             1..977
                     /gene="STON2"
                     /gene_synonym="STN2; STNB; STNB2"
                     /coded_by="XM_011537240.3:743..3676"
                     /db_xref="GeneID:85439"
                     /db_xref="HGNC:HGNC:30652"
                     /db_xref="MIM:608467"
ORIGIN      
        1 mttldhviat hqsewvsfne eppfpahsqg gteehlpgls sspdqsesss genhvvdggs
       61 qdhshseqdd ssekmglise aasppgspeq pppdlasais nwvqfeddtp wastspphqe
      121 taetalpltm pcwtcpsfds lgrcpltses swtthsedts spsfgcsytd lqlinaeeqt
      181 sgqasgadst dkrtewqtgr qtavspvqac sehtstrthr ldpsppspqp krsqnpgegp
      241 egasapndns sslqedeeve meaiswqass pamnghpapp vtsarfpswv tfddnevscp
      301 lppvtsplkp ntppsasvip dvpynsmgsf kkrdrpkstl mnfskvqkld isslnrtpsv
      361 teaspwratn pflnetlqdv qpspinpfsa ffeeqerrsq nssissttgk sqrdsliviy
      421 qdaisfddss ktqshsdave klkqlqiddp dhfgsatlpd ddpvawield ahppgsarsq
      481 prdgwpmmlr ipekknimss rhwgpifvkl tdtgylqlyy eqglekpfre fkleicheis
      541 eprlqnyden grihslridr vtykekkkyq pkpavahtae reqviklgtt nyddflsfih
      601 avqdrlmdlp vlsmdlstvg lnyleeeitv dvrdefsgiv skgdnqilqh hvltrihils
      661 flsglaecrl glndilvkgn eivlrqdimp ttttkwiklh ecrfhgcvde dvfhnsrvil
      721 fnpldacrfe lmrfrtvfae ktlpftlrta tsvngaevev qswlrmstgf sanrdpltqv
      781 pcenvmiryp vpsewvknfr resvlgeksl kakvnrgasf gstsvsgsep vmrvtlgtak
      841 yehafnsivw rinrlpdkns asghphcffc hlelgsdrev psrfanhvnv efsmpttsas
      901 kasvrsisve dktdvrkwvn ysahysyqtt etdnlpnply csclphtdlk rgskrvvkir
      961 wnaslevpla ssirtmv
//
LOCUS       XP_047287768             955 aa            linear   PRI 05-AUG-2025
DEFINITION  stonin-2 isoform X2 [Homo sapiens].
ACCESSION   XP_047287768
VERSION     XP_047287768.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431812.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..955
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..955
                     /product="stonin-2 isoform X2"
                     /calculated_mol_wt=106430
     Region          1..397
                     /region_name="Stonin2_N"
                     /note="Stonin 2; pfam12016"
                     /db_xref="CDD:403289"
     Region          616..933
                     /region_name="AP_stonin-2_MHD"
                     /note="Mu homology domain (MHD) of adaptor-like protein
                     (AP-like), stonin-2; cd09263"
                     /db_xref="CDD:271169"
     CDS             1..955
                     /gene="STON2"
                     /gene_synonym="STN2; STNB; STNB2"
                     /coded_by="XM_047431812.1:894..3761"
                     /db_xref="GeneID:85439"
                     /db_xref="HGNC:HGNC:30652"
                     /db_xref="MIM:608467"
ORIGIN      
        1 mttldhviat hqsewvsfne eppfpahsqg gteehlpgls sspdqsesss genhvvdggs
       61 qdhshseqdd ssekmglise aasppgspeq pppdlasais nwvqfeddtp wastspphqe
      121 taetalpltm pcwtcpsfds lgrcpltses swtthsedts spsfgcsytd lqlinaeeqt
      181 sgqasgadst dkrtewqtgr qtavspvqac sehtstrthr ldpsppspqp krsqnpgegp
      241 egasapndns sslqedeeve meaiswqass pamnghpapp vtsarfpswv tfddnevscp
      301 lppvtsplkp ntppsasvip dvpynsmgsf kkrdrpkstl mnfskvqkld isslnrtpsv
      361 teaspwratn pflnetlqdv qpspinpfsa ffeeqerrsq nssissttgk sqrdsliviy
      421 qdaisfddss ktqshsdave klkqlqiddp dhfgsatlpd ddpvawield ahppgsarsq
      481 prdgwpmmlr ipekknimss rhwgpifvkl tdtgylqlyy eqglekpfre fkleicheis
      541 eprlqnyden grihslridr vtykekkkyq pkpavahtae reqviklgtt nyddflsfih
      601 avqdrlmdlp vlsmdlstvg lnyleeeitv dvrdefsgiv skgdnqilqh hvltrihils
      661 flsglaecrl glndilvkgn eivlrqdimp ttttkwiklh ecrfhgcvde dvfhnsrvil
      721 fnpldacrfe lmrfrtvfae ktlpftlrta tsvngaevev qswlrmstgf sanrdpltqv
      781 pcenvmiryp vpsewvknfr resvlgeksl kakvnrgasf gstsvsgsep vmrvtlgtak
      841 yehafnsivw rinrlpdkns asghphcffc hlelgsdrev psrfanhvnv efsmpttsas
      901 kasvrsisve dktdvrkwvn ysahysyqve ieqkkslkpd fegdemenpk ecgvq
//
LOCUS       XP_011535544             955 aa            linear   PRI 05-AUG-2025
DEFINITION  stonin-2 isoform X2 [Homo sapiens].
ACCESSION   XP_011535544
VERSION     XP_011535544.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537242.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..955
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..955
                     /product="stonin-2 isoform X2"
                     /calculated_mol_wt=106430
     Region          1..397
                     /region_name="Stonin2_N"
                     /note="Stonin 2; pfam12016"
                     /db_xref="CDD:403289"
     Region          616..933
                     /region_name="AP_stonin-2_MHD"
                     /note="Mu homology domain (MHD) of adaptor-like protein
                     (AP-like), stonin-2; cd09263"
                     /db_xref="CDD:271169"
     CDS             1..955
                     /gene="STON2"
                     /gene_synonym="STN2; STNB; STNB2"
                     /coded_by="XM_011537242.3:455..3322"
                     /db_xref="GeneID:85439"
                     /db_xref="HGNC:HGNC:30652"
                     /db_xref="MIM:608467"
ORIGIN      
        1 mttldhviat hqsewvsfne eppfpahsqg gteehlpgls sspdqsesss genhvvdggs
       61 qdhshseqdd ssekmglise aasppgspeq pppdlasais nwvqfeddtp wastspphqe
      121 taetalpltm pcwtcpsfds lgrcpltses swtthsedts spsfgcsytd lqlinaeeqt
      181 sgqasgadst dkrtewqtgr qtavspvqac sehtstrthr ldpsppspqp krsqnpgegp
      241 egasapndns sslqedeeve meaiswqass pamnghpapp vtsarfpswv tfddnevscp
      301 lppvtsplkp ntppsasvip dvpynsmgsf kkrdrpkstl mnfskvqkld isslnrtpsv
      361 teaspwratn pflnetlqdv qpspinpfsa ffeeqerrsq nssissttgk sqrdsliviy
      421 qdaisfddss ktqshsdave klkqlqiddp dhfgsatlpd ddpvawield ahppgsarsq
      481 prdgwpmmlr ipekknimss rhwgpifvkl tdtgylqlyy eqglekpfre fkleicheis
      541 eprlqnyden grihslridr vtykekkkyq pkpavahtae reqviklgtt nyddflsfih
      601 avqdrlmdlp vlsmdlstvg lnyleeeitv dvrdefsgiv skgdnqilqh hvltrihils
      661 flsglaecrl glndilvkgn eivlrqdimp ttttkwiklh ecrfhgcvde dvfhnsrvil
      721 fnpldacrfe lmrfrtvfae ktlpftlrta tsvngaevev qswlrmstgf sanrdpltqv
      781 pcenvmiryp vpsewvknfr resvlgeksl kakvnrgasf gstsvsgsep vmrvtlgtak
      841 yehafnsivw rinrlpdkns asghphcffc hlelgsdrev psrfanhvnv efsmpttsas
      901 kasvrsisve dktdvrkwvn ysahysyqve ieqkkslkpd fegdemenpk ecgvq
//
LOCUS       XP_047287769             955 aa            linear   PRI 05-AUG-2025
DEFINITION  stonin-2 isoform X2 [Homo sapiens].
ACCESSION   XP_047287769
VERSION     XP_047287769.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431813.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..955
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..955
                     /product="stonin-2 isoform X2"
                     /calculated_mol_wt=106430
     Region          1..397
                     /region_name="Stonin2_N"
                     /note="Stonin 2; pfam12016"
                     /db_xref="CDD:403289"
     Region          616..933
                     /region_name="AP_stonin-2_MHD"
                     /note="Mu homology domain (MHD) of adaptor-like protein
                     (AP-like), stonin-2; cd09263"
                     /db_xref="CDD:271169"
     CDS             1..955
                     /gene="STON2"
                     /gene_synonym="STN2; STNB; STNB2"
                     /coded_by="XM_047431813.1:869..3736"
                     /db_xref="GeneID:85439"
                     /db_xref="HGNC:HGNC:30652"
                     /db_xref="MIM:608467"
ORIGIN      
        1 mttldhviat hqsewvsfne eppfpahsqg gteehlpgls sspdqsesss genhvvdggs
       61 qdhshseqdd ssekmglise aasppgspeq pppdlasais nwvqfeddtp wastspphqe
      121 taetalpltm pcwtcpsfds lgrcpltses swtthsedts spsfgcsytd lqlinaeeqt
      181 sgqasgadst dkrtewqtgr qtavspvqac sehtstrthr ldpsppspqp krsqnpgegp
      241 egasapndns sslqedeeve meaiswqass pamnghpapp vtsarfpswv tfddnevscp
      301 lppvtsplkp ntppsasvip dvpynsmgsf kkrdrpkstl mnfskvqkld isslnrtpsv
      361 teaspwratn pflnetlqdv qpspinpfsa ffeeqerrsq nssissttgk sqrdsliviy
      421 qdaisfddss ktqshsdave klkqlqiddp dhfgsatlpd ddpvawield ahppgsarsq
      481 prdgwpmmlr ipekknimss rhwgpifvkl tdtgylqlyy eqglekpfre fkleicheis
      541 eprlqnyden grihslridr vtykekkkyq pkpavahtae reqviklgtt nyddflsfih
      601 avqdrlmdlp vlsmdlstvg lnyleeeitv dvrdefsgiv skgdnqilqh hvltrihils
      661 flsglaecrl glndilvkgn eivlrqdimp ttttkwiklh ecrfhgcvde dvfhnsrvil
      721 fnpldacrfe lmrfrtvfae ktlpftlrta tsvngaevev qswlrmstgf sanrdpltqv
      781 pcenvmiryp vpsewvknfr resvlgeksl kakvnrgasf gstsvsgsep vmrvtlgtak
      841 yehafnsivw rinrlpdkns asghphcffc hlelgsdrev psrfanhvnv efsmpttsas
      901 kasvrsisve dktdvrkwvn ysahysyqve ieqkkslkpd fegdemenpk ecgvq
//
LOCUS       XP_024305504             920 aa            linear   PRI 05-AUG-2025
DEFINITION  stonin-2 isoform X3 [Homo sapiens].
ACCESSION   XP_024305504
VERSION     XP_024305504.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449736.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..920
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..920
                     /product="stonin-2 isoform X3"
                     /calculated_mol_wt=102704
     Region          1..340
                     /region_name="Stonin2_N"
                     /note="Stonin 2; pfam12016"
                     /db_xref="CDD:403289"
     Region          559..871
                     /region_name="AP_stonin-2_MHD"
                     /note="Mu homology domain (MHD) of adaptor-like protein
                     (AP-like), stonin-2; cd09263"
                     /db_xref="CDD:271169"
     CDS             1..920
                     /gene="STON2"
                     /gene_synonym="STN2; STNB; STNB2"
                     /coded_by="XM_024449736.2:455..3217"
                     /db_xref="GeneID:85439"
                     /db_xref="HGNC:HGNC:30652"
                     /db_xref="MIM:608467"
ORIGIN      
        1 mttldhviat hqsewvsfne eppfpahsqg gteehlpgls sspdqsesss genhvvdggs
       61 qdhshseqdd ssekmglise aasppgspeq pppdlasais nwvqfeddtp wastspphqe
      121 taetalpltm pcwtcpsfds lgrcpltses swtthsedts spsfgcsytd lqlinaeeqt
      181 sgqasgadst dnssslqede evemeaiswq asspamnghp appvtsarfp swvtfddnev
      241 scplppvtsp lkpntppsas vipdvpynsm gsfkkrdrpk stlmnfskvq kldisslnrt
      301 psvteaspwr atnpflnetl qdvqpspinp fsaffeeqer rsqnssisst tgksqrdsli
      361 viyqdaisfd dssktqshsd aveklkqlqi ddpdhfgsat lpdddpvawi eldahppgsa
      421 rsqprdgwpm mlripekkni mssrhwgpif vkltdtgylq lyyeqglekp frefkleich
      481 eiseprlqny dengrihslr idrvtykekk kyqpkpavah taereqvikl gttnyddfls
      541 fihavqdrlm dlpvlsmdls tvglnyleee itvdvrdefs givskgdnqi lqhhvltrih
      601 ilsflsglae crlglndilv kgneivlrqd impttttkwi klhecrfhgc vdedvfhnsr
      661 vilfnpldac rfelmrfrtv faektlpftl rtatsvngae vevqswlrms tgfsanrdpl
      721 tqvpcenvmi rypvpsewvk nfrresvlge kslkakvnrg asfgstsvsg sepvmrvtlg
      781 takyehafns ivwrinrlpd knsasghphc ffchlelgsd revpsrfanh vnvefsmptt
      841 saskasvrsi svedktdvrk wvnysahysy qttetdnlpn plycsclpht dlkrgskrvv
      901 kirwnaslev plassirtmv
//
LOCUS       XP_047287771             920 aa            linear   PRI 05-AUG-2025
DEFINITION  stonin-2 isoform X3 [Homo sapiens].
ACCESSION   XP_047287771
VERSION     XP_047287771.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431815.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..920
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..920
                     /product="stonin-2 isoform X3"
                     /calculated_mol_wt=102704
     Region          1..340
                     /region_name="Stonin2_N"
                     /note="Stonin 2; pfam12016"
                     /db_xref="CDD:403289"
     Region          559..871
                     /region_name="AP_stonin-2_MHD"
                     /note="Mu homology domain (MHD) of adaptor-like protein
                     (AP-like), stonin-2; cd09263"
                     /db_xref="CDD:271169"
     CDS             1..920
                     /gene="STON2"
                     /gene_synonym="STN2; STNB; STNB2"
                     /coded_by="XM_047431815.1:564..3326"
                     /db_xref="GeneID:85439"
                     /db_xref="HGNC:HGNC:30652"
                     /db_xref="MIM:608467"
ORIGIN      
        1 mttldhviat hqsewvsfne eppfpahsqg gteehlpgls sspdqsesss genhvvdggs
       61 qdhshseqdd ssekmglise aasppgspeq pppdlasais nwvqfeddtp wastspphqe
      121 taetalpltm pcwtcpsfds lgrcpltses swtthsedts spsfgcsytd lqlinaeeqt
      181 sgqasgadst dnssslqede evemeaiswq asspamnghp appvtsarfp swvtfddnev
      241 scplppvtsp lkpntppsas vipdvpynsm gsfkkrdrpk stlmnfskvq kldisslnrt
      301 psvteaspwr atnpflnetl qdvqpspinp fsaffeeqer rsqnssisst tgksqrdsli
      361 viyqdaisfd dssktqshsd aveklkqlqi ddpdhfgsat lpdddpvawi eldahppgsa
      421 rsqprdgwpm mlripekkni mssrhwgpif vkltdtgylq lyyeqglekp frefkleich
      481 eiseprlqny dengrihslr idrvtykekk kyqpkpavah taereqvikl gttnyddfls
      541 fihavqdrlm dlpvlsmdls tvglnyleee itvdvrdefs givskgdnqi lqhhvltrih
      601 ilsflsglae crlglndilv kgneivlrqd impttttkwi klhecrfhgc vdedvfhnsr
      661 vilfnpldac rfelmrfrtv faektlpftl rtatsvngae vevqswlrms tgfsanrdpl
      721 tqvpcenvmi rypvpsewvk nfrresvlge kslkakvnrg asfgstsvsg sepvmrvtlg
      781 takyehafns ivwrinrlpd knsasghphc ffchlelgsd revpsrfanh vnvefsmptt
      841 saskasvrsi svedktdvrk wvnysahysy qttetdnlpn plycsclpht dlkrgskrvv
      901 kirwnaslev plassirtmv
//
LOCUS       XP_047287772             898 aa            linear   PRI 05-AUG-2025
DEFINITION  stonin-2 isoform X4 [Homo sapiens].
ACCESSION   XP_047287772
VERSION     XP_047287772.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431816.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..898
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..898
                     /product="stonin-2 isoform X4"
                     /calculated_mol_wt=100299
     Region          1..340
                     /region_name="Stonin2_N"
                     /note="Stonin 2; pfam12016"
                     /db_xref="CDD:403289"
     Region          559..876
                     /region_name="AP_stonin-2_MHD"
                     /note="Mu homology domain (MHD) of adaptor-like protein
                     (AP-like), stonin-2; cd09263"
                     /db_xref="CDD:271169"
     CDS             1..898
                     /gene="STON2"
                     /gene_synonym="STN2; STNB; STNB2"
                     /coded_by="XM_047431816.1:564..3260"
                     /db_xref="GeneID:85439"
                     /db_xref="HGNC:HGNC:30652"
                     /db_xref="MIM:608467"
ORIGIN      
        1 mttldhviat hqsewvsfne eppfpahsqg gteehlpgls sspdqsesss genhvvdggs
       61 qdhshseqdd ssekmglise aasppgspeq pppdlasais nwvqfeddtp wastspphqe
      121 taetalpltm pcwtcpsfds lgrcpltses swtthsedts spsfgcsytd lqlinaeeqt
      181 sgqasgadst dnssslqede evemeaiswq asspamnghp appvtsarfp swvtfddnev
      241 scplppvtsp lkpntppsas vipdvpynsm gsfkkrdrpk stlmnfskvq kldisslnrt
      301 psvteaspwr atnpflnetl qdvqpspinp fsaffeeqer rsqnssisst tgksqrdsli
      361 viyqdaisfd dssktqshsd aveklkqlqi ddpdhfgsat lpdddpvawi eldahppgsa
      421 rsqprdgwpm mlripekkni mssrhwgpif vkltdtgylq lyyeqglekp frefkleich
      481 eiseprlqny dengrihslr idrvtykekk kyqpkpavah taereqvikl gttnyddfls
      541 fihavqdrlm dlpvlsmdls tvglnyleee itvdvrdefs givskgdnqi lqhhvltrih
      601 ilsflsglae crlglndilv kgneivlrqd impttttkwi klhecrfhgc vdedvfhnsr
      661 vilfnpldac rfelmrfrtv faektlpftl rtatsvngae vevqswlrms tgfsanrdpl
      721 tqvpcenvmi rypvpsewvk nfrresvlge kslkakvnrg asfgstsvsg sepvmrvtlg
      781 takyehafns ivwrinrlpd knsasghphc ffchlelgsd revpsrfanh vnvefsmptt
      841 saskasvrsi svedktdvrk wvnysahysy qveieqkksl kpdfegdeme npkecgvq
//
LOCUS       XP_047287773             898 aa            linear   PRI 05-AUG-2025
DEFINITION  stonin-2 isoform X4 [Homo sapiens].
ACCESSION   XP_047287773
VERSION     XP_047287773.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431817.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..898
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..898
                     /product="stonin-2 isoform X4"
                     /calculated_mol_wt=100299
     Region          1..340
                     /region_name="Stonin2_N"
                     /note="Stonin 2; pfam12016"
                     /db_xref="CDD:403289"
     Region          559..876
                     /region_name="AP_stonin-2_MHD"
                     /note="Mu homology domain (MHD) of adaptor-like protein
                     (AP-like), stonin-2; cd09263"
                     /db_xref="CDD:271169"
     CDS             1..898
                     /gene="STON2"
                     /gene_synonym="STN2; STNB; STNB2"
                     /coded_by="XM_047431817.1:743..3439"
                     /db_xref="GeneID:85439"
                     /db_xref="HGNC:HGNC:30652"
                     /db_xref="MIM:608467"
ORIGIN      
        1 mttldhviat hqsewvsfne eppfpahsqg gteehlpgls sspdqsesss genhvvdggs
       61 qdhshseqdd ssekmglise aasppgspeq pppdlasais nwvqfeddtp wastspphqe
      121 taetalpltm pcwtcpsfds lgrcpltses swtthsedts spsfgcsytd lqlinaeeqt
      181 sgqasgadst dnssslqede evemeaiswq asspamnghp appvtsarfp swvtfddnev
      241 scplppvtsp lkpntppsas vipdvpynsm gsfkkrdrpk stlmnfskvq kldisslnrt
      301 psvteaspwr atnpflnetl qdvqpspinp fsaffeeqer rsqnssisst tgksqrdsli
      361 viyqdaisfd dssktqshsd aveklkqlqi ddpdhfgsat lpdddpvawi eldahppgsa
      421 rsqprdgwpm mlripekkni mssrhwgpif vkltdtgylq lyyeqglekp frefkleich
      481 eiseprlqny dengrihslr idrvtykekk kyqpkpavah taereqvikl gttnyddfls
      541 fihavqdrlm dlpvlsmdls tvglnyleee itvdvrdefs givskgdnqi lqhhvltrih
      601 ilsflsglae crlglndilv kgneivlrqd impttttkwi klhecrfhgc vdedvfhnsr
      661 vilfnpldac rfelmrfrtv faektlpftl rtatsvngae vevqswlrms tgfsanrdpl
      721 tqvpcenvmi rypvpsewvk nfrresvlge kslkakvnrg asfgstsvsg sepvmrvtlg
      781 takyehafns ivwrinrlpd knsasghphc ffchlelgsd revpsrfanh vnvefsmptt
      841 saskasvrsi svedktdvrk wvnysahysy qveieqkksl kpdfegdeme npkecgvq
//
LOCUS       XP_016877205            2576 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger homeobox protein 2 isoform X1 [Homo sapiens].
ACCESSION   XP_016877205
VERSION     XP_016877205.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021716.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2576
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2576
                     /product="zinc finger homeobox protein 2 isoform X1"
                     /calculated_mol_wt=274472
     Region          455..475
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          508..532
                     /region_name="zf-H2C2_5"
                     /note="C2H2-type zinc-finger domain; pfam13909"
                     /db_xref="CDD:404746"
     Region          510..527
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          1197..1219
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          1254..1272
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          1599..1656
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          1862..1918
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          2070..2126
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          <2211..2369
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          2457..2500
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275371"
     Site            order(2464..2466,2468..2469,2473,2499,2506,2509..2513,
                     2515..2516)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275371"
     Region          2501..2523
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275371"
     CDS             1..2576
                     /gene="ZFHX2"
                     /gene_synonym="MARSIS; ZFH-5; ZFH5; ZNF409"
                     /coded_by="XM_017021716.3:473..8203"
                     /db_xref="GeneID:85446"
                     /db_xref="HGNC:HGNC:20152"
                     /db_xref="MIM:617828"
ORIGIN      
        1 matlnsastt gttpspghna pslpsdtfss stpsdpvtkd ppaasstsen mrssepggql
       61 lesgcglvpp keigepqegp dcghfppndp gvekdkeqee eeeglppmdl snhlfftagg
      121 eaylvaklsl pggselllpk gfpwgeagik eepslpflay pppshltalh iqhgfdpiqg
      181 fsssdqilsh dtsapspaac eerhgafwsy qlapnppgdp kdgpmgnsgg nhvavfwlcl
      241 lcrlgfskpq afmdhtqshg vkltpaqyqg lsgspavlqe gdegckalis flepklparp
      301 ssdipldnss tvnmeanvaq tedgppeaev qalilldeev malsppsppt atwdpsptqa
      361 kespvaagea gpdwfpegqe edgglcppln qssptskegg tlpapvgspe dpsdppqpyr
      421 laddytpapa afqglslssh msllhsrnsc ktlkcpkcnw hykyqqtldv hmrekhpesn
      481 shcsycsagg ahprlarges yncgykpyrc dvcnystttk gnlsihmqsd khlanlqgfq
      541 agpggqgspp easlppsagd kepktksswq ckvcsyetni srnlrihmts ekhmqnvlml
      601 hqglplglpp glmgpgpppp pgatptsppe lfqyfgpqal gqpqtplagp glrpdkplea
      661 qlllngfhhv gaparkfpts apgslspdah lppsqllgss sdslptsppp ddslslkvfr
      721 clvcqafstd slelllyhcs igrslpeaew kevagdthrc klccygtqlk anfqlhlktd
      781 khaqkyqlaa hlregggamg tpspaslgdg apygsvsplh lrcnicdfes nskekmqlha
      841 rgaaheensq iykflldmeg aeagaelgly hcllcawetp srlavlqhlr tpahrdaqaq
      901 rrlqllqngp tteeglaalq silsfshgql rtpgkapvtp laepptpekd aqnkteqlas
      961 eetenktgps rdsanqttvr igvyccpycs flspessqvr ahtlsqhavq pkyrcplcqe
     1021 qlvgrpalhf hlshlhnvvp ecveklllva ttvemtfttk vlsaptlspl dngqeppthg
     1081 peptpsrdqa aegpnltpea spdplpeppl asvevpdkps gspgqppspa pspvpepdaq
     1141 aedvappptm aeeeegttge lrsaepapad srhpltyrkt tnfaldkfld parpykctvc
     1201 kesftqknil lvhynsvshl hkmkkaaidp sapargeaga pptttaatdk pfkctvcrvs
     1261 ynqsstleih mrsvlhqtrs rgtktdskie gpersqeepk egetegevgt ekkgpdtsgf
     1321 isglpflspp pppldlhrfp aplftppvlp pfplvpesll klqqqqlllp fylhdlkvgp
     1381 kltlagpapv lslpaatppp ppqppkaela erewerppma kegneagpss ppdplpneaa
     1441 rtaakallen fgfelviqyn egkqavpppp tppppealgg gdklacgacg klfsnmlilk
     1501 theehvhrrf lpfealsrya aqfrksydsl ypplaeppkp pdgsldspvp hlgppflvpe
     1561 peaggtrape ersragghwp ieeeessrgn lpplvpagrr fsrtkftefq tqalqsffet
     1621 saypkdgeve rlasllglas rvvvvwfqna rqkarknace ggsmptgggt ggasgcrrch
     1681 atfscvfelv rhlkkcyddq tleeeeeeae rgeeeeevee eeveeeqgle ppagpegplp
     1741 eppdgeelsq aeatkaggke peekatpsps pahtcdqcai sfssqdllts hrrlhflpsl
     1801 qpsappqlld lpllvfgern plvaatspmp gpplkrkhed gslsptgsea ggggegeppr
     1861 dkrlrttilp eqleilyrwy mqdsnptrkm ldciseevgl kkrvvqvwfq ntrarerkgq
     1921 frstpggvps pavkppatat paslpkfnll lgkvddgtgr eapkreapaf pyptatlasg
     1981 pqpflppgke attptpeppl pllpppppse eegpeeppka speseacsls agdlsdssas
     2041 slaepespga ggtsggpggg tgvpdgmgqr ryrtqmsslq lkimkacyea yrtptmqece
     2101 vlgeeiglpk rviqvwfqna rakekkaklq gtaagstggs segllaaqrt dcpycdvkyd
     2161 fyvscrghlf srqhlaklke avraqlkses kcydlapape appalkappa ttpasmplga
     2221 aptlprlapv llsgpalaqp plgnlapfns gpaassgllg latsvlpttt vvqtagpgrp
     2281 lpqrpmpdqt ntstagttdp vpgppteplg dkvsserkpv agptsssnda lknlkalktt
     2341 vpallggqfl pfplppaggt appavfgpql qgayfqqlyg mkkglfpmnp mipqtligll
     2401 pnallqpppq ppeptatapp kppelpapge geagevdell tgstgistvd vthrylcrqc
     2461 kmafdgeapa tahqrsfcff grgsggsmpp plrvpictyh clacevllsg realashlrs
     2521 sahrrkaapp qggppisitn aataasaava fakeearlph tdsnpktttt stllal
//
LOCUS       XP_047287774            2576 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger homeobox protein 2 isoform X1 [Homo sapiens].
ACCESSION   XP_047287774
VERSION     XP_047287774.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431818.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2576
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2576
                     /product="zinc finger homeobox protein 2 isoform X1"
                     /calculated_mol_wt=274472
     Region          455..475
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          508..532
                     /region_name="zf-H2C2_5"
                     /note="C2H2-type zinc-finger domain; pfam13909"
                     /db_xref="CDD:404746"
     Region          510..527
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          1197..1219
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          1254..1272
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          1599..1656
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          1862..1918
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          2070..2126
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          <2211..2369
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          2457..2500
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275371"
     Site            order(2464..2466,2468..2469,2473,2499,2506,2509..2513,
                     2515..2516)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275371"
     Region          2501..2523
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275371"
     CDS             1..2576
                     /gene="ZFHX2"
                     /gene_synonym="MARSIS; ZFH-5; ZFH5; ZNF409"
                     /coded_by="XM_047431818.1:280..8010"
                     /db_xref="GeneID:85446"
                     /db_xref="HGNC:HGNC:20152"
                     /db_xref="MIM:617828"
ORIGIN      
        1 matlnsastt gttpspghna pslpsdtfss stpsdpvtkd ppaasstsen mrssepggql
       61 lesgcglvpp keigepqegp dcghfppndp gvekdkeqee eeeglppmdl snhlfftagg
      121 eaylvaklsl pggselllpk gfpwgeagik eepslpflay pppshltalh iqhgfdpiqg
      181 fsssdqilsh dtsapspaac eerhgafwsy qlapnppgdp kdgpmgnsgg nhvavfwlcl
      241 lcrlgfskpq afmdhtqshg vkltpaqyqg lsgspavlqe gdegckalis flepklparp
      301 ssdipldnss tvnmeanvaq tedgppeaev qalilldeev malsppsppt atwdpsptqa
      361 kespvaagea gpdwfpegqe edgglcppln qssptskegg tlpapvgspe dpsdppqpyr
      421 laddytpapa afqglslssh msllhsrnsc ktlkcpkcnw hykyqqtldv hmrekhpesn
      481 shcsycsagg ahprlarges yncgykpyrc dvcnystttk gnlsihmqsd khlanlqgfq
      541 agpggqgspp easlppsagd kepktksswq ckvcsyetni srnlrihmts ekhmqnvlml
      601 hqglplglpp glmgpgpppp pgatptsppe lfqyfgpqal gqpqtplagp glrpdkplea
      661 qlllngfhhv gaparkfpts apgslspdah lppsqllgss sdslptsppp ddslslkvfr
      721 clvcqafstd slelllyhcs igrslpeaew kevagdthrc klccygtqlk anfqlhlktd
      781 khaqkyqlaa hlregggamg tpspaslgdg apygsvsplh lrcnicdfes nskekmqlha
      841 rgaaheensq iykflldmeg aeagaelgly hcllcawetp srlavlqhlr tpahrdaqaq
      901 rrlqllqngp tteeglaalq silsfshgql rtpgkapvtp laepptpekd aqnkteqlas
      961 eetenktgps rdsanqttvr igvyccpycs flspessqvr ahtlsqhavq pkyrcplcqe
     1021 qlvgrpalhf hlshlhnvvp ecveklllva ttvemtfttk vlsaptlspl dngqeppthg
     1081 peptpsrdqa aegpnltpea spdplpeppl asvevpdkps gspgqppspa pspvpepdaq
     1141 aedvappptm aeeeegttge lrsaepapad srhpltyrkt tnfaldkfld parpykctvc
     1201 kesftqknil lvhynsvshl hkmkkaaidp sapargeaga pptttaatdk pfkctvcrvs
     1261 ynqsstleih mrsvlhqtrs rgtktdskie gpersqeepk egetegevgt ekkgpdtsgf
     1321 isglpflspp pppldlhrfp aplftppvlp pfplvpesll klqqqqlllp fylhdlkvgp
     1381 kltlagpapv lslpaatppp ppqppkaela erewerppma kegneagpss ppdplpneaa
     1441 rtaakallen fgfelviqyn egkqavpppp tppppealgg gdklacgacg klfsnmlilk
     1501 theehvhrrf lpfealsrya aqfrksydsl ypplaeppkp pdgsldspvp hlgppflvpe
     1561 peaggtrape ersragghwp ieeeessrgn lpplvpagrr fsrtkftefq tqalqsffet
     1621 saypkdgeve rlasllglas rvvvvwfqna rqkarknace ggsmptgggt ggasgcrrch
     1681 atfscvfelv rhlkkcyddq tleeeeeeae rgeeeeevee eeveeeqgle ppagpegplp
     1741 eppdgeelsq aeatkaggke peekatpsps pahtcdqcai sfssqdllts hrrlhflpsl
     1801 qpsappqlld lpllvfgern plvaatspmp gpplkrkhed gslsptgsea ggggegeppr
     1861 dkrlrttilp eqleilyrwy mqdsnptrkm ldciseevgl kkrvvqvwfq ntrarerkgq
     1921 frstpggvps pavkppatat paslpkfnll lgkvddgtgr eapkreapaf pyptatlasg
     1981 pqpflppgke attptpeppl pllpppppse eegpeeppka speseacsls agdlsdssas
     2041 slaepespga ggtsggpggg tgvpdgmgqr ryrtqmsslq lkimkacyea yrtptmqece
     2101 vlgeeiglpk rviqvwfqna rakekkaklq gtaagstggs segllaaqrt dcpycdvkyd
     2161 fyvscrghlf srqhlaklke avraqlkses kcydlapape appalkappa ttpasmplga
     2221 aptlprlapv llsgpalaqp plgnlapfns gpaassgllg latsvlpttt vvqtagpgrp
     2281 lpqrpmpdqt ntstagttdp vpgppteplg dkvsserkpv agptsssnda lknlkalktt
     2341 vpallggqfl pfplppaggt appavfgpql qgayfqqlyg mkkglfpmnp mipqtligll
     2401 pnallqpppq ppeptatapp kppelpapge geagevdell tgstgistvd vthrylcrqc
     2461 kmafdgeapa tahqrsfcff grgsggsmpp plrvpictyh clacevllsg realashlrs
     2521 sahrrkaapp qggppisitn aataasaava fakeearlph tdsnpktttt stllal
//
LOCUS       XP_047287775            2576 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger homeobox protein 2 isoform X1 [Homo sapiens].
ACCESSION   XP_047287775
VERSION     XP_047287775.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431819.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2576
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2576
                     /product="zinc finger homeobox protein 2 isoform X1"
                     /calculated_mol_wt=274472
     Region          455..475
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          508..532
                     /region_name="zf-H2C2_5"
                     /note="C2H2-type zinc-finger domain; pfam13909"
                     /db_xref="CDD:404746"
     Region          510..527
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          1197..1219
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          1254..1272
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          1599..1656
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          1862..1918
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          2070..2126
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          <2211..2369
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          2457..2500
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275371"
     Site            order(2464..2466,2468..2469,2473,2499,2506,2509..2513,
                     2515..2516)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275371"
     Region          2501..2523
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275371"
     CDS             1..2576
                     /gene="ZFHX2"
                     /gene_synonym="MARSIS; ZFH-5; ZFH5; ZNF409"
                     /coded_by="XM_047431819.1:107..7837"
                     /db_xref="GeneID:85446"
                     /db_xref="HGNC:HGNC:20152"
                     /db_xref="MIM:617828"
ORIGIN      
        1 matlnsastt gttpspghna pslpsdtfss stpsdpvtkd ppaasstsen mrssepggql
       61 lesgcglvpp keigepqegp dcghfppndp gvekdkeqee eeeglppmdl snhlfftagg
      121 eaylvaklsl pggselllpk gfpwgeagik eepslpflay pppshltalh iqhgfdpiqg
      181 fsssdqilsh dtsapspaac eerhgafwsy qlapnppgdp kdgpmgnsgg nhvavfwlcl
      241 lcrlgfskpq afmdhtqshg vkltpaqyqg lsgspavlqe gdegckalis flepklparp
      301 ssdipldnss tvnmeanvaq tedgppeaev qalilldeev malsppsppt atwdpsptqa
      361 kespvaagea gpdwfpegqe edgglcppln qssptskegg tlpapvgspe dpsdppqpyr
      421 laddytpapa afqglslssh msllhsrnsc ktlkcpkcnw hykyqqtldv hmrekhpesn
      481 shcsycsagg ahprlarges yncgykpyrc dvcnystttk gnlsihmqsd khlanlqgfq
      541 agpggqgspp easlppsagd kepktksswq ckvcsyetni srnlrihmts ekhmqnvlml
      601 hqglplglpp glmgpgpppp pgatptsppe lfqyfgpqal gqpqtplagp glrpdkplea
      661 qlllngfhhv gaparkfpts apgslspdah lppsqllgss sdslptsppp ddslslkvfr
      721 clvcqafstd slelllyhcs igrslpeaew kevagdthrc klccygtqlk anfqlhlktd
      781 khaqkyqlaa hlregggamg tpspaslgdg apygsvsplh lrcnicdfes nskekmqlha
      841 rgaaheensq iykflldmeg aeagaelgly hcllcawetp srlavlqhlr tpahrdaqaq
      901 rrlqllqngp tteeglaalq silsfshgql rtpgkapvtp laepptpekd aqnkteqlas
      961 eetenktgps rdsanqttvr igvyccpycs flspessqvr ahtlsqhavq pkyrcplcqe
     1021 qlvgrpalhf hlshlhnvvp ecveklllva ttvemtfttk vlsaptlspl dngqeppthg
     1081 peptpsrdqa aegpnltpea spdplpeppl asvevpdkps gspgqppspa pspvpepdaq
     1141 aedvappptm aeeeegttge lrsaepapad srhpltyrkt tnfaldkfld parpykctvc
     1201 kesftqknil lvhynsvshl hkmkkaaidp sapargeaga pptttaatdk pfkctvcrvs
     1261 ynqsstleih mrsvlhqtrs rgtktdskie gpersqeepk egetegevgt ekkgpdtsgf
     1321 isglpflspp pppldlhrfp aplftppvlp pfplvpesll klqqqqlllp fylhdlkvgp
     1381 kltlagpapv lslpaatppp ppqppkaela erewerppma kegneagpss ppdplpneaa
     1441 rtaakallen fgfelviqyn egkqavpppp tppppealgg gdklacgacg klfsnmlilk
     1501 theehvhrrf lpfealsrya aqfrksydsl ypplaeppkp pdgsldspvp hlgppflvpe
     1561 peaggtrape ersragghwp ieeeessrgn lpplvpagrr fsrtkftefq tqalqsffet
     1621 saypkdgeve rlasllglas rvvvvwfqna rqkarknace ggsmptgggt ggasgcrrch
     1681 atfscvfelv rhlkkcyddq tleeeeeeae rgeeeeevee eeveeeqgle ppagpegplp
     1741 eppdgeelsq aeatkaggke peekatpsps pahtcdqcai sfssqdllts hrrlhflpsl
     1801 qpsappqlld lpllvfgern plvaatspmp gpplkrkhed gslsptgsea ggggegeppr
     1861 dkrlrttilp eqleilyrwy mqdsnptrkm ldciseevgl kkrvvqvwfq ntrarerkgq
     1921 frstpggvps pavkppatat paslpkfnll lgkvddgtgr eapkreapaf pyptatlasg
     1981 pqpflppgke attptpeppl pllpppppse eegpeeppka speseacsls agdlsdssas
     2041 slaepespga ggtsggpggg tgvpdgmgqr ryrtqmsslq lkimkacyea yrtptmqece
     2101 vlgeeiglpk rviqvwfqna rakekkaklq gtaagstggs segllaaqrt dcpycdvkyd
     2161 fyvscrghlf srqhlaklke avraqlkses kcydlapape appalkappa ttpasmplga
     2221 aptlprlapv llsgpalaqp plgnlapfns gpaassgllg latsvlpttt vvqtagpgrp
     2281 lpqrpmpdqt ntstagttdp vpgppteplg dkvsserkpv agptsssnda lknlkalktt
     2341 vpallggqfl pfplppaggt appavfgpql qgayfqqlyg mkkglfpmnp mipqtligll
     2401 pnallqpppq ppeptatapp kppelpapge geagevdell tgstgistvd vthrylcrqc
     2461 kmafdgeapa tahqrsfcff grgsggsmpp plrvpictyh clacevllsg realashlrs
     2521 sahrrkaapp qggppisitn aataasaava fakeearlph tdsnpktttt stllal
//
LOCUS       XP_047287776            2576 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger homeobox protein 2 isoform X1 [Homo sapiens].
ACCESSION   XP_047287776
VERSION     XP_047287776.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431820.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2576
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2576
                     /product="zinc finger homeobox protein 2 isoform X1"
                     /calculated_mol_wt=274472
     Region          455..475
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          508..532
                     /region_name="zf-H2C2_5"
                     /note="C2H2-type zinc-finger domain; pfam13909"
                     /db_xref="CDD:404746"
     Region          510..527
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          1197..1219
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          1254..1272
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          1599..1656
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          1862..1918
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          2070..2126
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          <2211..2369
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          2457..2500
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275371"
     Site            order(2464..2466,2468..2469,2473,2499,2506,2509..2513,
                     2515..2516)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275371"
     Region          2501..2523
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275371"
     CDS             1..2576
                     /gene="ZFHX2"
                     /gene_synonym="MARSIS; ZFH-5; ZFH5; ZNF409"
                     /coded_by="XM_047431820.1:1355..9085"
                     /db_xref="GeneID:85446"
                     /db_xref="HGNC:HGNC:20152"
                     /db_xref="MIM:617828"
ORIGIN      
        1 matlnsastt gttpspghna pslpsdtfss stpsdpvtkd ppaasstsen mrssepggql
       61 lesgcglvpp keigepqegp dcghfppndp gvekdkeqee eeeglppmdl snhlfftagg
      121 eaylvaklsl pggselllpk gfpwgeagik eepslpflay pppshltalh iqhgfdpiqg
      181 fsssdqilsh dtsapspaac eerhgafwsy qlapnppgdp kdgpmgnsgg nhvavfwlcl
      241 lcrlgfskpq afmdhtqshg vkltpaqyqg lsgspavlqe gdegckalis flepklparp
      301 ssdipldnss tvnmeanvaq tedgppeaev qalilldeev malsppsppt atwdpsptqa
      361 kespvaagea gpdwfpegqe edgglcppln qssptskegg tlpapvgspe dpsdppqpyr
      421 laddytpapa afqglslssh msllhsrnsc ktlkcpkcnw hykyqqtldv hmrekhpesn
      481 shcsycsagg ahprlarges yncgykpyrc dvcnystttk gnlsihmqsd khlanlqgfq
      541 agpggqgspp easlppsagd kepktksswq ckvcsyetni srnlrihmts ekhmqnvlml
      601 hqglplglpp glmgpgpppp pgatptsppe lfqyfgpqal gqpqtplagp glrpdkplea
      661 qlllngfhhv gaparkfpts apgslspdah lppsqllgss sdslptsppp ddslslkvfr
      721 clvcqafstd slelllyhcs igrslpeaew kevagdthrc klccygtqlk anfqlhlktd
      781 khaqkyqlaa hlregggamg tpspaslgdg apygsvsplh lrcnicdfes nskekmqlha
      841 rgaaheensq iykflldmeg aeagaelgly hcllcawetp srlavlqhlr tpahrdaqaq
      901 rrlqllqngp tteeglaalq silsfshgql rtpgkapvtp laepptpekd aqnkteqlas
      961 eetenktgps rdsanqttvr igvyccpycs flspessqvr ahtlsqhavq pkyrcplcqe
     1021 qlvgrpalhf hlshlhnvvp ecveklllva ttvemtfttk vlsaptlspl dngqeppthg
     1081 peptpsrdqa aegpnltpea spdplpeppl asvevpdkps gspgqppspa pspvpepdaq
     1141 aedvappptm aeeeegttge lrsaepapad srhpltyrkt tnfaldkfld parpykctvc
     1201 kesftqknil lvhynsvshl hkmkkaaidp sapargeaga pptttaatdk pfkctvcrvs
     1261 ynqsstleih mrsvlhqtrs rgtktdskie gpersqeepk egetegevgt ekkgpdtsgf
     1321 isglpflspp pppldlhrfp aplftppvlp pfplvpesll klqqqqlllp fylhdlkvgp
     1381 kltlagpapv lslpaatppp ppqppkaela erewerppma kegneagpss ppdplpneaa
     1441 rtaakallen fgfelviqyn egkqavpppp tppppealgg gdklacgacg klfsnmlilk
     1501 theehvhrrf lpfealsrya aqfrksydsl ypplaeppkp pdgsldspvp hlgppflvpe
     1561 peaggtrape ersragghwp ieeeessrgn lpplvpagrr fsrtkftefq tqalqsffet
     1621 saypkdgeve rlasllglas rvvvvwfqna rqkarknace ggsmptgggt ggasgcrrch
     1681 atfscvfelv rhlkkcyddq tleeeeeeae rgeeeeevee eeveeeqgle ppagpegplp
     1741 eppdgeelsq aeatkaggke peekatpsps pahtcdqcai sfssqdllts hrrlhflpsl
     1801 qpsappqlld lpllvfgern plvaatspmp gpplkrkhed gslsptgsea ggggegeppr
     1861 dkrlrttilp eqleilyrwy mqdsnptrkm ldciseevgl kkrvvqvwfq ntrarerkgq
     1921 frstpggvps pavkppatat paslpkfnll lgkvddgtgr eapkreapaf pyptatlasg
     1981 pqpflppgke attptpeppl pllpppppse eegpeeppka speseacsls agdlsdssas
     2041 slaepespga ggtsggpggg tgvpdgmgqr ryrtqmsslq lkimkacyea yrtptmqece
     2101 vlgeeiglpk rviqvwfqna rakekkaklq gtaagstggs segllaaqrt dcpycdvkyd
     2161 fyvscrghlf srqhlaklke avraqlkses kcydlapape appalkappa ttpasmplga
     2221 aptlprlapv llsgpalaqp plgnlapfns gpaassgllg latsvlpttt vvqtagpgrp
     2281 lpqrpmpdqt ntstagttdp vpgppteplg dkvsserkpv agptsssnda lknlkalktt
     2341 vpallggqfl pfplppaggt appavfgpql qgayfqqlyg mkkglfpmnp mipqtligll
     2401 pnallqpppq ppeptatapp kppelpapge geagevdell tgstgistvd vthrylcrqc
     2461 kmafdgeapa tahqrsfcff grgsggsmpp plrvpictyh clacevllsg realashlrs
     2521 sahrrkaapp qggppisitn aataasaava fakeearlph tdsnpktttt stllal
//
LOCUS       XP_047287777            2576 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger homeobox protein 2 isoform X1 [Homo sapiens].
ACCESSION   XP_047287777
VERSION     XP_047287777.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431821.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2576
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2576
                     /product="zinc finger homeobox protein 2 isoform X1"
                     /calculated_mol_wt=274472
     Region          455..475
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          508..532
                     /region_name="zf-H2C2_5"
                     /note="C2H2-type zinc-finger domain; pfam13909"
                     /db_xref="CDD:404746"
     Region          510..527
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          1197..1219
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          1254..1272
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          1599..1656
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          1862..1918
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          2070..2126
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          <2211..2369
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          2457..2500
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275371"
     Site            order(2464..2466,2468..2469,2473,2499,2506,2509..2513,
                     2515..2516)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275371"
     Region          2501..2523
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275371"
     CDS             1..2576
                     /gene="ZFHX2"
                     /gene_synonym="MARSIS; ZFH-5; ZFH5; ZNF409"
                     /coded_by="XM_047431821.1:272..8002"
                     /db_xref="GeneID:85446"
                     /db_xref="HGNC:HGNC:20152"
                     /db_xref="MIM:617828"
ORIGIN      
        1 matlnsastt gttpspghna pslpsdtfss stpsdpvtkd ppaasstsen mrssepggql
       61 lesgcglvpp keigepqegp dcghfppndp gvekdkeqee eeeglppmdl snhlfftagg
      121 eaylvaklsl pggselllpk gfpwgeagik eepslpflay pppshltalh iqhgfdpiqg
      181 fsssdqilsh dtsapspaac eerhgafwsy qlapnppgdp kdgpmgnsgg nhvavfwlcl
      241 lcrlgfskpq afmdhtqshg vkltpaqyqg lsgspavlqe gdegckalis flepklparp
      301 ssdipldnss tvnmeanvaq tedgppeaev qalilldeev malsppsppt atwdpsptqa
      361 kespvaagea gpdwfpegqe edgglcppln qssptskegg tlpapvgspe dpsdppqpyr
      421 laddytpapa afqglslssh msllhsrnsc ktlkcpkcnw hykyqqtldv hmrekhpesn
      481 shcsycsagg ahprlarges yncgykpyrc dvcnystttk gnlsihmqsd khlanlqgfq
      541 agpggqgspp easlppsagd kepktksswq ckvcsyetni srnlrihmts ekhmqnvlml
      601 hqglplglpp glmgpgpppp pgatptsppe lfqyfgpqal gqpqtplagp glrpdkplea
      661 qlllngfhhv gaparkfpts apgslspdah lppsqllgss sdslptsppp ddslslkvfr
      721 clvcqafstd slelllyhcs igrslpeaew kevagdthrc klccygtqlk anfqlhlktd
      781 khaqkyqlaa hlregggamg tpspaslgdg apygsvsplh lrcnicdfes nskekmqlha
      841 rgaaheensq iykflldmeg aeagaelgly hcllcawetp srlavlqhlr tpahrdaqaq
      901 rrlqllqngp tteeglaalq silsfshgql rtpgkapvtp laepptpekd aqnkteqlas
      961 eetenktgps rdsanqttvr igvyccpycs flspessqvr ahtlsqhavq pkyrcplcqe
     1021 qlvgrpalhf hlshlhnvvp ecveklllva ttvemtfttk vlsaptlspl dngqeppthg
     1081 peptpsrdqa aegpnltpea spdplpeppl asvevpdkps gspgqppspa pspvpepdaq
     1141 aedvappptm aeeeegttge lrsaepapad srhpltyrkt tnfaldkfld parpykctvc
     1201 kesftqknil lvhynsvshl hkmkkaaidp sapargeaga pptttaatdk pfkctvcrvs
     1261 ynqsstleih mrsvlhqtrs rgtktdskie gpersqeepk egetegevgt ekkgpdtsgf
     1321 isglpflspp pppldlhrfp aplftppvlp pfplvpesll klqqqqlllp fylhdlkvgp
     1381 kltlagpapv lslpaatppp ppqppkaela erewerppma kegneagpss ppdplpneaa
     1441 rtaakallen fgfelviqyn egkqavpppp tppppealgg gdklacgacg klfsnmlilk
     1501 theehvhrrf lpfealsrya aqfrksydsl ypplaeppkp pdgsldspvp hlgppflvpe
     1561 peaggtrape ersragghwp ieeeessrgn lpplvpagrr fsrtkftefq tqalqsffet
     1621 saypkdgeve rlasllglas rvvvvwfqna rqkarknace ggsmptgggt ggasgcrrch
     1681 atfscvfelv rhlkkcyddq tleeeeeeae rgeeeeevee eeveeeqgle ppagpegplp
     1741 eppdgeelsq aeatkaggke peekatpsps pahtcdqcai sfssqdllts hrrlhflpsl
     1801 qpsappqlld lpllvfgern plvaatspmp gpplkrkhed gslsptgsea ggggegeppr
     1861 dkrlrttilp eqleilyrwy mqdsnptrkm ldciseevgl kkrvvqvwfq ntrarerkgq
     1921 frstpggvps pavkppatat paslpkfnll lgkvddgtgr eapkreapaf pyptatlasg
     1981 pqpflppgke attptpeppl pllpppppse eegpeeppka speseacsls agdlsdssas
     2041 slaepespga ggtsggpggg tgvpdgmgqr ryrtqmsslq lkimkacyea yrtptmqece
     2101 vlgeeiglpk rviqvwfqna rakekkaklq gtaagstggs segllaaqrt dcpycdvkyd
     2161 fyvscrghlf srqhlaklke avraqlkses kcydlapape appalkappa ttpasmplga
     2221 aptlprlapv llsgpalaqp plgnlapfns gpaassgllg latsvlpttt vvqtagpgrp
     2281 lpqrpmpdqt ntstagttdp vpgppteplg dkvsserkpv agptsssnda lknlkalktt
     2341 vpallggqfl pfplppaggt appavfgpql qgayfqqlyg mkkglfpmnp mipqtligll
     2401 pnallqpppq ppeptatapp kppelpapge geagevdell tgstgistvd vthrylcrqc
     2461 kmafdgeapa tahqrsfcff grgsggsmpp plrvpictyh clacevllsg realashlrs
     2521 sahrrkaapp qggppisitn aataasaava fakeearlph tdsnpktttt stllal
//
LOCUS       XP_011535547            2572 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger homeobox protein 2 isoform X2 [Homo sapiens].
ACCESSION   XP_011535547
VERSION     XP_011535547.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537245.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2572
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2572
                     /product="zinc finger homeobox protein 2 isoform X2"
                     /calculated_mol_wt=274046
     Region          455..475
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          508..532
                     /region_name="zf-H2C2_5"
                     /note="C2H2-type zinc-finger domain; pfam13909"
                     /db_xref="CDD:404746"
     Region          510..527
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          1193..1215
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          1250..1268
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          1595..1652
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          1858..1914
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          2066..2122
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          <2207..2365
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          2453..2496
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275371"
     Site            order(2460..2462,2464..2465,2469,2495,2502,2505..2509,
                     2511..2512)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275371"
     Region          2497..2519
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275371"
     CDS             1..2572
                     /gene="ZFHX2"
                     /gene_synonym="MARSIS; ZFH-5; ZFH5; ZNF409"
                     /coded_by="XM_011537245.4:280..7998"
                     /db_xref="GeneID:85446"
                     /db_xref="HGNC:HGNC:20152"
                     /db_xref="MIM:617828"
ORIGIN      
        1 matlnsastt gttpspghna pslpsdtfss stpsdpvtkd ppaasstsen mrssepggql
       61 lesgcglvpp keigepqegp dcghfppndp gvekdkeqee eeeglppmdl snhlfftagg
      121 eaylvaklsl pggselllpk gfpwgeagik eepslpflay pppshltalh iqhgfdpiqg
      181 fsssdqilsh dtsapspaac eerhgafwsy qlapnppgdp kdgpmgnsgg nhvavfwlcl
      241 lcrlgfskpq afmdhtqshg vkltpaqyqg lsgspavlqe gdegckalis flepklparp
      301 ssdipldnss tvnmeanvaq tedgppeaev qalilldeev malsppsppt atwdpsptqa
      361 kespvaagea gpdwfpegqe edgglcppln qssptskegg tlpapvgspe dpsdppqpyr
      421 laddytpapa afqglslssh msllhsrnsc ktlkcpkcnw hykyqqtldv hmrekhpesn
      481 shcsycsagg ahprlarges yncgykpyrc dvcnystttk gnlsihmqsd khlanlqgfq
      541 agpggqgspp easlppsagd kepktksswq ckvcsyetni srnlrihmts ekhmqnvlml
      601 hqglplglpp glmgpgpppp pgatptsppe lfqyfgpqal gqpqtplagp glrpdkplea
      661 qlllngfhhv gaparkfpts apgslspdah lppsqllgss sdslptsppp ddslslkvfr
      721 clvcqafstd slelllyhcs igrslpeaew kevagdthrc klccygtqlk anfqlhlktd
      781 khaqkyqlaa hlregggamg tpspaslgdg apygsvsplh lrcnicdfes nskekmqlha
      841 rgaaheensq iykflldmeg aeagaelgly hcllcawetp srlavlqhlr tpahrdaqaq
      901 rrlqllqngp tteeglaalq silsfshgql rtpgkapvtp laepptpekd aqnkteqlas
      961 eetenktgps rdsanqttvy ccpycsflsp essqvrahtl sqhavqpkyr cplcqeqlvg
     1021 rpalhfhlsh lhnvvpecve klllvattve mtfttkvlsa ptlspldngq eppthgpept
     1081 psrdqaaegp nltpeaspdp lpepplasve vpdkpsgspg qppspapspv pepdaqaedv
     1141 appptmaeee egttgelrsa epapadsrhp ltyrkttnfa ldkfldparp ykctvckesf
     1201 tqknillvhy nsvshlhkmk kaaidpsapa rgeagapptt taatdkpfkc tvcrvsynqs
     1261 stleihmrsv lhqtrsrgtk tdskiegper sqeepkeget egevgtekkg pdtsgfisgl
     1321 pflspppppl dlhrfpaplf tppvlppfpl vpesllklqq qqlllpfylh dlkvgpkltl
     1381 agpapvlslp aatpppppqp pkaelaerew erppmakegn eagpssppdp lpneaartaa
     1441 kallenfgfe lviqynegkq avpppptppp pealgggdkl acgacgklfs nmlilkthee
     1501 hvhrrflpfe alsryaaqfr ksydslyppl aeppkppdgs ldspvphlgp pflvpepeag
     1561 gtrapeersr agghwpieee essrgnlppl vpagrrfsrt kftefqtqal qsffetsayp
     1621 kdgeverlas llglasrvvv vwfqnarqka rknaceggsm ptgggtggas gcrrchatfs
     1681 cvfelvrhlk kcyddqtlee eeeeaergee eeeveeeeve eeqgleppag pegplpeppd
     1741 geelsqaeat kaggkepeek atpspspaht cdqcaisfss qdlltshrrl hflpslqpsa
     1801 ppqlldlpll vfgernplva atspmpgppl krkhedgsls ptgseagggg egepprdkrl
     1861 rttilpeqle ilyrwymqds nptrkmldci seevglkkrv vqvwfqntra rerkgqfrst
     1921 pggvpspavk ppatatpasl pkfnlllgkv ddgtgreapk reapafpypt atlasgpqpf
     1981 lppgkeattp tpepplpllp ppppseeegp eeppkaspes eacslsagdl sdssasslae
     2041 pespgaggts ggpgggtgvp dgmgqrryrt qmsslqlkim kacyeayrtp tmqecevlge
     2101 eiglpkrviq vwfqnarake kkaklqgtaa gstggssegl laaqrtdcpy cdvkydfyvs
     2161 crghlfsrqh laklkeavra qlkseskcyd lapapeappa lkappattpa smplgaaptl
     2221 prlapvllsg palaqpplgn lapfnsgpaa ssgllglats vlptttvvqt agpgrplpqr
     2281 pmpdqtntst agttdpvpgp pteplgdkvs serkpvagpt sssndalknl kalkttvpal
     2341 lggqflpfpl ppaggtappa vfgpqlqgay fqqlygmkkg lfpmnpmipq tligllpnal
     2401 lqpppqppep tatappkppe lpapgegeag evdelltgst gistvdvthr ylcrqckmaf
     2461 dgeapatahq rsfcffgrgs ggsmppplrv pictyhclac evllsgreal ashlrssahr
     2521 rkaappqggp pisitnaata asaavafake earlphtdsn pkttttstll al
//
LOCUS       XP_047287778            2546 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger homeobox protein 2 isoform X3 [Homo sapiens].
ACCESSION   XP_047287778
VERSION     XP_047287778.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431822.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2546
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2546
                     /product="zinc finger homeobox protein 2 isoform X3"
                     /calculated_mol_wt=271580
     Region          455..475
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          508..532
                     /region_name="zf-H2C2_5"
                     /note="C2H2-type zinc-finger domain; pfam13909"
                     /db_xref="CDD:404746"
     Region          510..527
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          1167..1189
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          1224..1242
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          1569..1626
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          1832..1888
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          2040..2096
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          <2181..2339
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          2427..2470
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275371"
     Site            order(2434..2436,2438..2439,2443,2469,2476,2479..2483,
                     2485..2486)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275371"
     Region          2471..2493
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275371"
     CDS             1..2546
                     /gene="ZFHX2"
                     /gene_synonym="MARSIS; ZFH-5; ZFH5; ZNF409"
                     /coded_by="XM_047431822.1:473..8113"
                     /db_xref="GeneID:85446"
                     /db_xref="HGNC:HGNC:20152"
                     /db_xref="MIM:617828"
ORIGIN      
        1 matlnsastt gttpspghna pslpsdtfss stpsdpvtkd ppaasstsen mrssepggql
       61 lesgcglvpp keigepqegp dcghfppndp gvekdkeqee eeeglppmdl snhlfftagg
      121 eaylvaklsl pggselllpk gfpwgeagik eepslpflay pppshltalh iqhgfdpiqg
      181 fsssdqilsh dtsapspaac eerhgafwsy qlapnppgdp kdgpmgnsgg nhvavfwlcl
      241 lcrlgfskpq afmdhtqshg vkltpaqyqg lsgspavlqe gdegckalis flepklparp
      301 ssdipldnss tvnmeanvaq tedgppeaev qalilldeev malsppsppt atwdpsptqa
      361 kespvaagea gpdwfpegqe edgglcppln qssptskegg tlpapvgspe dpsdppqpyr
      421 laddytpapa afqglslssh msllhsrnsc ktlkcpkcnw hykyqqtldv hmrekhpesn
      481 shcsycsagg ahprlarges yncgykpyrc dvcnystttk gnlsihmqsd khlanlqgfq
      541 agpggqgspp easlppsagd kepktksswq ckvcsyetni srnlrihmts ekhmqnvlml
      601 hqglplglpp glmgpgpppp pgatptsppe lfqyfgpqal gqpqtplagp glrpdkplea
      661 qlllngfhhv gaparkfpts ddslslkvfr clvcqafstd slelllyhcs igrslpeaew
      721 kevagdthrc klccygtqlk anfqlhlktd khaqkyqlaa hlregggamg tpspaslgdg
      781 apygsvsplh lrcnicdfes nskekmqlha rgaaheensq iykflldmeg aeagaelgly
      841 hcllcawetp srlavlqhlr tpahrdaqaq rrlqllqngp tteeglaalq silsfshgql
      901 rtpgkapvtp laepptpekd aqnkteqlas eetenktgps rdsanqttvr igvyccpycs
      961 flspessqvr ahtlsqhavq pkyrcplcqe qlvgrpalhf hlshlhnvvp ecveklllva
     1021 ttvemtfttk vlsaptlspl dngqeppthg peptpsrdqa aegpnltpea spdplpeppl
     1081 asvevpdkps gspgqppspa pspvpepdaq aedvappptm aeeeegttge lrsaepapad
     1141 srhpltyrkt tnfaldkfld parpykctvc kesftqknil lvhynsvshl hkmkkaaidp
     1201 sapargeaga pptttaatdk pfkctvcrvs ynqsstleih mrsvlhqtrs rgtktdskie
     1261 gpersqeepk egetegevgt ekkgpdtsgf isglpflspp pppldlhrfp aplftppvlp
     1321 pfplvpesll klqqqqlllp fylhdlkvgp kltlagpapv lslpaatppp ppqppkaela
     1381 erewerppma kegneagpss ppdplpneaa rtaakallen fgfelviqyn egkqavpppp
     1441 tppppealgg gdklacgacg klfsnmlilk theehvhrrf lpfealsrya aqfrksydsl
     1501 ypplaeppkp pdgsldspvp hlgppflvpe peaggtrape ersragghwp ieeeessrgn
     1561 lpplvpagrr fsrtkftefq tqalqsffet saypkdgeve rlasllglas rvvvvwfqna
     1621 rqkarknace ggsmptgggt ggasgcrrch atfscvfelv rhlkkcyddq tleeeeeeae
     1681 rgeeeeevee eeveeeqgle ppagpegplp eppdgeelsq aeatkaggke peekatpsps
     1741 pahtcdqcai sfssqdllts hrrlhflpsl qpsappqlld lpllvfgern plvaatspmp
     1801 gpplkrkhed gslsptgsea ggggegeppr dkrlrttilp eqleilyrwy mqdsnptrkm
     1861 ldciseevgl kkrvvqvwfq ntrarerkgq frstpggvps pavkppatat paslpkfnll
     1921 lgkvddgtgr eapkreapaf pyptatlasg pqpflppgke attptpeppl pllpppppse
     1981 eegpeeppka speseacsls agdlsdssas slaepespga ggtsggpggg tgvpdgmgqr
     2041 ryrtqmsslq lkimkacyea yrtptmqece vlgeeiglpk rviqvwfqna rakekkaklq
     2101 gtaagstggs segllaaqrt dcpycdvkyd fyvscrghlf srqhlaklke avraqlkses
     2161 kcydlapape appalkappa ttpasmplga aptlprlapv llsgpalaqp plgnlapfns
     2221 gpaassgllg latsvlpttt vvqtagpgrp lpqrpmpdqt ntstagttdp vpgppteplg
     2281 dkvsserkpv agptsssnda lknlkalktt vpallggqfl pfplppaggt appavfgpql
     2341 qgayfqqlyg mkkglfpmnp mipqtligll pnallqpppq ppeptatapp kppelpapge
     2401 geagevdell tgstgistvd vthrylcrqc kmafdgeapa tahqrsfcff grgsggsmpp
     2461 plrvpictyh clacevllsg realashlrs sahrrkaapp qggppisitn aataasaava
     2521 fakeearlph tdsnpktttt stllal
//
LOCUS       XP_047287779            2542 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger homeobox protein 2 isoform X4 [Homo sapiens].
ACCESSION   XP_047287779
VERSION     XP_047287779.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431823.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2542
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2542
                     /product="zinc finger homeobox protein 2 isoform X4"
                     /calculated_mol_wt=271154
     Region          455..475
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          508..532
                     /region_name="zf-H2C2_5"
                     /note="C2H2-type zinc-finger domain; pfam13909"
                     /db_xref="CDD:404746"
     Region          510..527
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          1163..1185
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          1220..1238
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          1565..1622
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          1828..1884
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          2036..2092
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          <2177..2335
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          2423..2466
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275371"
     Site            order(2430..2432,2434..2435,2439,2465,2472,2475..2479,
                     2481..2482)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275371"
     Region          2467..2489
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275371"
     CDS             1..2542
                     /gene="ZFHX2"
                     /gene_synonym="MARSIS; ZFH-5; ZFH5; ZNF409"
                     /coded_by="XM_047431823.1:473..8101"
                     /db_xref="GeneID:85446"
                     /db_xref="HGNC:HGNC:20152"
                     /db_xref="MIM:617828"
ORIGIN      
        1 matlnsastt gttpspghna pslpsdtfss stpsdpvtkd ppaasstsen mrssepggql
       61 lesgcglvpp keigepqegp dcghfppndp gvekdkeqee eeeglppmdl snhlfftagg
      121 eaylvaklsl pggselllpk gfpwgeagik eepslpflay pppshltalh iqhgfdpiqg
      181 fsssdqilsh dtsapspaac eerhgafwsy qlapnppgdp kdgpmgnsgg nhvavfwlcl
      241 lcrlgfskpq afmdhtqshg vkltpaqyqg lsgspavlqe gdegckalis flepklparp
      301 ssdipldnss tvnmeanvaq tedgppeaev qalilldeev malsppsppt atwdpsptqa
      361 kespvaagea gpdwfpegqe edgglcppln qssptskegg tlpapvgspe dpsdppqpyr
      421 laddytpapa afqglslssh msllhsrnsc ktlkcpkcnw hykyqqtldv hmrekhpesn
      481 shcsycsagg ahprlarges yncgykpyrc dvcnystttk gnlsihmqsd khlanlqgfq
      541 agpggqgspp easlppsagd kepktksswq ckvcsyetni srnlrihmts ekhmqnvlml
      601 hqglplglpp glmgpgpppp pgatptsppe lfqyfgpqal gqpqtplagp glrpdkplea
      661 qlllngfhhv gaparkfpts ddslslkvfr clvcqafstd slelllyhcs igrslpeaew
      721 kevagdthrc klccygtqlk anfqlhlktd khaqkyqlaa hlregggamg tpspaslgdg
      781 apygsvsplh lrcnicdfes nskekmqlha rgaaheensq iykflldmeg aeagaelgly
      841 hcllcawetp srlavlqhlr tpahrdaqaq rrlqllqngp tteeglaalq silsfshgql
      901 rtpgkapvtp laepptpekd aqnkteqlas eetenktgps rdsanqttvy ccpycsflsp
      961 essqvrahtl sqhavqpkyr cplcqeqlvg rpalhfhlsh lhnvvpecve klllvattve
     1021 mtfttkvlsa ptlspldngq eppthgpept psrdqaaegp nltpeaspdp lpepplasve
     1081 vpdkpsgspg qppspapspv pepdaqaedv appptmaeee egttgelrsa epapadsrhp
     1141 ltyrkttnfa ldkfldparp ykctvckesf tqknillvhy nsvshlhkmk kaaidpsapa
     1201 rgeagapptt taatdkpfkc tvcrvsynqs stleihmrsv lhqtrsrgtk tdskiegper
     1261 sqeepkeget egevgtekkg pdtsgfisgl pflspppppl dlhrfpaplf tppvlppfpl
     1321 vpesllklqq qqlllpfylh dlkvgpkltl agpapvlslp aatpppppqp pkaelaerew
     1381 erppmakegn eagpssppdp lpneaartaa kallenfgfe lviqynegkq avpppptppp
     1441 pealgggdkl acgacgklfs nmlilkthee hvhrrflpfe alsryaaqfr ksydslyppl
     1501 aeppkppdgs ldspvphlgp pflvpepeag gtrapeersr agghwpieee essrgnlppl
     1561 vpagrrfsrt kftefqtqal qsffetsayp kdgeverlas llglasrvvv vwfqnarqka
     1621 rknaceggsm ptgggtggas gcrrchatfs cvfelvrhlk kcyddqtlee eeeeaergee
     1681 eeeveeeeve eeqgleppag pegplpeppd geelsqaeat kaggkepeek atpspspaht
     1741 cdqcaisfss qdlltshrrl hflpslqpsa ppqlldlpll vfgernplva atspmpgppl
     1801 krkhedgsls ptgseagggg egepprdkrl rttilpeqle ilyrwymqds nptrkmldci
     1861 seevglkkrv vqvwfqntra rerkgqfrst pggvpspavk ppatatpasl pkfnlllgkv
     1921 ddgtgreapk reapafpypt atlasgpqpf lppgkeattp tpepplpllp ppppseeegp
     1981 eeppkaspes eacslsagdl sdssasslae pespgaggts ggpgggtgvp dgmgqrryrt
     2041 qmsslqlkim kacyeayrtp tmqecevlge eiglpkrviq vwfqnarake kkaklqgtaa
     2101 gstggssegl laaqrtdcpy cdvkydfyvs crghlfsrqh laklkeavra qlkseskcyd
     2161 lapapeappa lkappattpa smplgaaptl prlapvllsg palaqpplgn lapfnsgpaa
     2221 ssgllglats vlptttvvqt agpgrplpqr pmpdqtntst agttdpvpgp pteplgdkvs
     2281 serkpvagpt sssndalknl kalkttvpal lggqflpfpl ppaggtappa vfgpqlqgay
     2341 fqqlygmkkg lfpmnpmipq tligllpnal lqpppqppep tatappkppe lpapgegeag
     2401 evdelltgst gistvdvthr ylcrqckmaf dgeapatahq rsfcffgrgs ggsmppplrv
     2461 pictyhclac evllsgreal ashlrssahr rkaappqggp pisitnaata asaavafake
     2521 earlphtdsn pkttttstll al
//
LOCUS       XP_047287780            2529 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger homeobox protein 2 isoform X5 [Homo sapiens].
ACCESSION   XP_047287780
VERSION     XP_047287780.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431824.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2529
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2529
                     /product="zinc finger homeobox protein 2 isoform X5"
                     /calculated_mol_wt=269670
     Region          455..475
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          508..532
                     /region_name="zf-H2C2_5"
                     /note="C2H2-type zinc-finger domain; pfam13909"
                     /db_xref="CDD:404746"
     Region          510..527
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          1150..1172
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          1207..1225
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          1552..1609
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          1815..1871
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          2023..2079
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          <2164..2322
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          2410..2453
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275371"
     Site            order(2417..2419,2421..2422,2426,2452,2459,2462..2466,
                     2468..2469)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275371"
     Region          2454..2476
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275371"
     CDS             1..2529
                     /gene="ZFHX2"
                     /gene_synonym="MARSIS; ZFH-5; ZFH5; ZNF409"
                     /coded_by="XM_047431824.1:280..7869"
                     /db_xref="GeneID:85446"
                     /db_xref="HGNC:HGNC:20152"
                     /db_xref="MIM:617828"
ORIGIN      
        1 matlnsastt gttpspghna pslpsdtfss stpsdpvtkd ppaasstsen mrssepggql
       61 lesgcglvpp keigepqegp dcghfppndp gvekdkeqee eeeglppmdl snhlfftagg
      121 eaylvaklsl pggselllpk gfpwgeagik eepslpflay pppshltalh iqhgfdpiqg
      181 fsssdqilsh dtsapspaac eerhgafwsy qlapnppgdp kdgpmgnsgg nhvavfwlcl
      241 lcrlgfskpq afmdhtqshg vkltpaqyqg lsgspavlqe gdegckalis flepklparp
      301 ssdipldnss tvnmeanvaq tedgppeaev qalilldeev malsppsppt atwdpsptqa
      361 kespvaagea gpdwfpegqe edgglcppln qssptskegg tlpapvgspe dpsdppqpyr
      421 laddytpapa afqglslssh msllhsrnsc ktlkcpkcnw hykyqqtldv hmrekhpesn
      481 shcsycsagg ahprlarges yncgykpyrc dvcnystttk gnlsihmqsd khlanlqgfq
      541 agpggqgspp easlppsagd kepktksswq ckvcsyetni srnlrihmts ekhmqnvlml
      601 hqglplglpp glmgpgpppp pgatptsppe lfqyfgpqal gqpqtplagp glrpdkplea
      661 qlllngfhhv gaparkfpts apgslspdah lppsqllgss sdslptsppp ddslslkvfr
      721 clvcqafstd slelllyhcs igrslpeaew kevagdthrc klccygtqlk anfqlhlktd
      781 khaqnkekmq lhargaahee nsqiykflld megaeagael glyhcllcaw etpsrlavlq
      841 hlrtpahrda qaqrrlqllq ngptteegla alqsilsfsh gqlrtpgkap vtplaepptp
      901 ekdaqnkteq laseetenkt gpsrdsanqt tvrigvyccp ycsflspess qvrahtlsqh
      961 avqpkyrcpl cqeqlvgrpa lhfhlshlhn vvpecvekll lvattvemtf ttkvlsaptl
     1021 spldngqepp thgpeptpsr dqaaegpnlt peaspdplpe pplasvevpd kpsgspgqpp
     1081 spapspvpep daqaedvapp ptmaeeeegt tgelrsaepa padsrhplty rkttnfaldk
     1141 fldparpykc tvckesftqk nillvhynsv shlhkmkkaa idpsaparge agapptttaa
     1201 tdkpfkctvc rvsynqsstl eihmrsvlhq trsrgtktds kiegpersqe epkegetege
     1261 vgtekkgpdt sgfisglpfl spppppldlh rfpaplftpp vlppfplvpe sllklqqqql
     1321 llpfylhdlk vgpkltlagp apvlslpaat pppppqppka elaerewerp pmakegneag
     1381 pssppdplpn eaartaakal lenfgfelvi qynegkqavp ppptppppea lgggdklacg
     1441 acgklfsnml ilktheehvh rrflpfeals ryaaqfrksy dslypplaep pkppdgslds
     1501 pvphlgppfl vpepeaggtr apeersragg hwpieeeess rgnlpplvpa grrfsrtkft
     1561 efqtqalqsf fetsaypkdg everlasllg lasrvvvvwf qnarqkarkn aceggsmptg
     1621 ggtggasgcr rchatfscvf elvrhlkkcy ddqtleeeee eaergeeeee veeeeveeeq
     1681 gleppagpeg plpeppdgee lsqaeatkag gkepeekatp spspahtcdq caisfssqdl
     1741 ltshrrlhfl pslqpsappq lldlpllvfg ernplvaats pmpgpplkrk hedgslsptg
     1801 seaggggege pprdkrlrtt ilpeqleily rwymqdsnpt rkmldcisee vglkkrvvqv
     1861 wfqntrarer kgqfrstpgg vpspavkppa tatpaslpkf nlllgkvddg tgreapkrea
     1921 pafpyptatl asgpqpflpp gkeattptpe pplpllpppp pseeegpeep pkaspeseac
     1981 slsagdlsds sasslaepes pgaggtsggp gggtgvpdgm gqrryrtqms slqlkimkac
     2041 yeayrtptmq ecevlgeeig lpkrviqvwf qnarakekka klqgtaagst ggssegllaa
     2101 qrtdcpycdv kydfyvscrg hlfsrqhlak lkeavraqlk seskcydlap apeappalka
     2161 ppattpasmp lgaaptlprl apvllsgpal aqpplgnlap fnsgpaassg llglatsvlp
     2221 tttvvqtagp grplpqrpmp dqtntstagt tdpvpgppte plgdkvsser kpvagptsss
     2281 ndalknlkal kttvpallgg qflpfplppa ggtappavfg pqlqgayfqq lygmkkglfp
     2341 mnpmipqtli gllpnallqp ppqppeptat appkppelpa pgegeagevd elltgstgis
     2401 tvdvthrylc rqckmafdge apatahqrsf cffgrgsggs mppplrvpic tyhclacevl
     2461 lsgrealash lrssahrrka appqggppis itnaataasa avafakeear lphtdsnpkt
     2521 tttstllal
//
LOCUS       XP_005268192            1602 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger homeobox protein 2 isoform X6 [Homo sapiens].
ACCESSION   XP_005268192
VERSION     XP_005268192.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005268135.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1602
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1602
                     /product="zinc finger homeobox protein 2 isoform X6"
                     /calculated_mol_wt=170704
     Region          223..245
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          280..298
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          625..682
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          888..944
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          1096..1152
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          <1237..1395
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          1483..1526
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275371"
     Site            order(1490..1492,1494..1495,1499,1525,1532,1535..1539,
                     1541..1542)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275371"
     Region          1527..1549
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275371"
     CDS             1..1602
                     /gene="ZFHX2"
                     /gene_synonym="MARSIS; ZFH-5; ZFH5; ZNF409"
                     /coded_by="XM_005268135.4:407..5215"
                     /db_xref="GeneID:85446"
                     /db_xref="HGNC:HGNC:20152"
                     /db_xref="MIM:617828"
ORIGIN      
        1 mswllsrqvy ccpycsflsp essqvrahtl sqhavqpkyr cplcqeqlvg rpalhfhlsh
       61 lhnvvpecve klllvattve mtfttkvlsa ptlspldngq eppthgpept psrdqaaegp
      121 nltpeaspdp lpepplasve vpdkpsgspg qppspapspv pepdaqaedv appptmaeee
      181 egttgelrsa epapadsrhp ltyrkttnfa ldkfldparp ykctvckesf tqknillvhy
      241 nsvshlhkmk kaaidpsapa rgeagapptt taatdkpfkc tvcrvsynqs stleihmrsv
      301 lhqtrsrgtk tdskiegper sqeepkeget egevgtekkg pdtsgfisgl pflspppppl
      361 dlhrfpaplf tppvlppfpl vpesllklqq qqlllpfylh dlkvgpkltl agpapvlslp
      421 aatpppppqp pkaelaerew erppmakegn eagpssppdp lpneaartaa kallenfgfe
      481 lviqynegkq avpppptppp pealgggdkl acgacgklfs nmlilkthee hvhrrflpfe
      541 alsryaaqfr ksydslyppl aeppkppdgs ldspvphlgp pflvpepeag gtrapeersr
      601 agghwpieee essrgnlppl vpagrrfsrt kftefqtqal qsffetsayp kdgeverlas
      661 llglasrvvv vwfqnarqka rknaceggsm ptgggtggas gcrrchatfs cvfelvrhlk
      721 kcyddqtlee eeeeaergee eeeveeeeve eeqgleppag pegplpeppd geelsqaeat
      781 kaggkepeek atpspspaht cdqcaisfss qdlltshrrl hflpslqpsa ppqlldlpll
      841 vfgernplva atspmpgppl krkhedgsls ptgseagggg egepprdkrl rttilpeqle
      901 ilyrwymqds nptrkmldci seevglkkrv vqvwfqntra rerkgqfrst pggvpspavk
      961 ppatatpasl pkfnlllgkv ddgtgreapk reapafpypt atlasgpqpf lppgkeattp
     1021 tpepplpllp ppppseeegp eeppkaspes eacslsagdl sdssasslae pespgaggts
     1081 ggpgggtgvp dgmgqrryrt qmsslqlkim kacyeayrtp tmqecevlge eiglpkrviq
     1141 vwfqnarake kkaklqgtaa gstggssegl laaqrtdcpy cdvkydfyvs crghlfsrqh
     1201 laklkeavra qlkseskcyd lapapeappa lkappattpa smplgaaptl prlapvllsg
     1261 palaqpplgn lapfnsgpaa ssgllglats vlptttvvqt agpgrplpqr pmpdqtntst
     1321 agttdpvpgp pteplgdkvs serkpvagpt sssndalknl kalkttvpal lggqflpfpl
     1381 ppaggtappa vfgpqlqgay fqqlygmkkg lfpmnpmipq tligllpnal lqpppqppep
     1441 tatappkppe lpapgegeag evdelltgst gistvdvthr ylcrqckmaf dgeapatahq
     1501 rsfcffgrgs ggsmppplrv pictyhclac evllsgreal ashlrssahr rkaappqggp
     1561 pisitnaata asaavafake earlphtdsn pkttttstll al
//
LOCUS       XP_011535554            1602 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger homeobox protein 2 isoform X6 [Homo sapiens].
ACCESSION   XP_011535554
VERSION     XP_011535554.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537252.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1602
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1602
                     /product="zinc finger homeobox protein 2 isoform X6"
                     /calculated_mol_wt=170704
     Region          223..245
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          280..298
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          625..682
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          888..944
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          1096..1152
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          <1237..1395
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          1483..1526
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275371"
     Site            order(1490..1492,1494..1495,1499,1525,1532,1535..1539,
                     1541..1542)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275371"
     Region          1527..1549
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275371"
     CDS             1..1602
                     /gene="ZFHX2"
                     /gene_synonym="MARSIS; ZFH-5; ZFH5; ZNF409"
                     /coded_by="XM_011537252.3:463..5271"
                     /db_xref="GeneID:85446"
                     /db_xref="HGNC:HGNC:20152"
                     /db_xref="MIM:617828"
ORIGIN      
        1 mswllsrqvy ccpycsflsp essqvrahtl sqhavqpkyr cplcqeqlvg rpalhfhlsh
       61 lhnvvpecve klllvattve mtfttkvlsa ptlspldngq eppthgpept psrdqaaegp
      121 nltpeaspdp lpepplasve vpdkpsgspg qppspapspv pepdaqaedv appptmaeee
      181 egttgelrsa epapadsrhp ltyrkttnfa ldkfldparp ykctvckesf tqknillvhy
      241 nsvshlhkmk kaaidpsapa rgeagapptt taatdkpfkc tvcrvsynqs stleihmrsv
      301 lhqtrsrgtk tdskiegper sqeepkeget egevgtekkg pdtsgfisgl pflspppppl
      361 dlhrfpaplf tppvlppfpl vpesllklqq qqlllpfylh dlkvgpkltl agpapvlslp
      421 aatpppppqp pkaelaerew erppmakegn eagpssppdp lpneaartaa kallenfgfe
      481 lviqynegkq avpppptppp pealgggdkl acgacgklfs nmlilkthee hvhrrflpfe
      541 alsryaaqfr ksydslyppl aeppkppdgs ldspvphlgp pflvpepeag gtrapeersr
      601 agghwpieee essrgnlppl vpagrrfsrt kftefqtqal qsffetsayp kdgeverlas
      661 llglasrvvv vwfqnarqka rknaceggsm ptgggtggas gcrrchatfs cvfelvrhlk
      721 kcyddqtlee eeeeaergee eeeveeeeve eeqgleppag pegplpeppd geelsqaeat
      781 kaggkepeek atpspspaht cdqcaisfss qdlltshrrl hflpslqpsa ppqlldlpll
      841 vfgernplva atspmpgppl krkhedgsls ptgseagggg egepprdkrl rttilpeqle
      901 ilyrwymqds nptrkmldci seevglkkrv vqvwfqntra rerkgqfrst pggvpspavk
      961 ppatatpasl pkfnlllgkv ddgtgreapk reapafpypt atlasgpqpf lppgkeattp
     1021 tpepplpllp ppppseeegp eeppkaspes eacslsagdl sdssasslae pespgaggts
     1081 ggpgggtgvp dgmgqrryrt qmsslqlkim kacyeayrtp tmqecevlge eiglpkrviq
     1141 vwfqnarake kkaklqgtaa gstggssegl laaqrtdcpy cdvkydfyvs crghlfsrqh
     1201 laklkeavra qlkseskcyd lapapeappa lkappattpa smplgaaptl prlapvllsg
     1261 palaqpplgn lapfnsgpaa ssgllglats vlptttvvqt agpgrplpqr pmpdqtntst
     1321 agttdpvpgp pteplgdkvs serkpvagpt sssndalknl kalkttvpal lggqflpfpl
     1381 ppaggtappa vfgpqlqgay fqqlygmkkg lfpmnpmipq tligllpnal lqpppqppep
     1441 tatappkppe lpapgegeag evdelltgst gistvdvthr ylcrqckmaf dgeapatahq
     1501 rsfcffgrgs ggsmppplrv pictyhclac evllsgreal ashlrssahr rkaappqggp
     1561 pisitnaata asaavafake earlphtdsn pkttttstll al
//
LOCUS       XP_047287781            1522 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger homeobox protein 2 isoform X7 [Homo sapiens].
ACCESSION   XP_047287781
VERSION     XP_047287781.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431825.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1522
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1522
                     /product="zinc finger homeobox protein 2 isoform X7"
                     /calculated_mol_wt=161578
     Region          143..165
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          200..218
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          545..602
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          719..741
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          808..864
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          1016..1072
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          <1157..1315
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          1403..1446
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275371"
     Site            order(1410..1412,1414..1415,1419,1445,1452,1455..1459,
                     1461..1462)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275371"
     Region          1447..1469
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275371"
     CDS             1..1522
                     /gene="ZFHX2"
                     /gene_synonym="MARSIS; ZFH-5; ZFH5; ZNF409"
                     /coded_by="XM_047431825.1:434..5002"
                     /db_xref="GeneID:85446"
                     /db_xref="HGNC:HGNC:20152"
                     /db_xref="MIM:617828"
ORIGIN      
        1 mtfttkvlsa ptlspldngq eppthgpept psrdqaaegp nltpeaspdp lpepplasve
       61 vpdkpsgspg qppspapspv pepdaqaedv appptmaeee egttgelrsa epapadsrhp
      121 ltyrkttnfa ldkfldparp ykctvckesf tqknillvhy nsvshlhkmk kaaidpsapa
      181 rgeagapptt taatdkpfkc tvcrvsynqs stleihmrsv lhqtrsrgtk tdskiegper
      241 sqeepkeget egevgtekkg pdtsgfisgl pflspppppl dlhrfpaplf tppvlppfpl
      301 vpesllklqq qqlllpfylh dlkvgpkltl agpapvlslp aatpppppqp pkaelaerew
      361 erppmakegn eagpssppdp lpneaartaa kallenfgfe lviqynegkq avpppptppp
      421 pealgggdkl acgacgklfs nmlilkthee hvhrrflpfe alsryaaqfr ksydslyppl
      481 aeppkppdgs ldspvphlgp pflvpepeag gtrapeersr agghwpieee essrgnlppl
      541 vpagrrfsrt kftefqtqal qsffetsayp kdgeverlas llglasrvvv vwfqnarqka
      601 rknaceggsm ptgggtggas gcrrchatfs cvfelvrhlk kcyddqtlee eeeeaergee
      661 eeeveeeeve eeqgleppag pegplpeppd geelsqaeat kaggkepeek atpspspaht
      721 cdqcaisfss qdlltshrrl hflpslqpsa ppqlldlpll vfgernplva atspmpgppl
      781 krkhedgsls ptgseagggg egepprdkrl rttilpeqle ilyrwymqds nptrkmldci
      841 seevglkkrv vqvwfqntra rerkgqfrst pggvpspavk ppatatpasl pkfnlllgkv
      901 ddgtgreapk reapafpypt atlasgpqpf lppgkeattp tpepplpllp ppppseeegp
      961 eeppkaspes eacslsagdl sdssasslae pespgaggts ggpgggtgvp dgmgqrryrt
     1021 qmsslqlkim kacyeayrtp tmqecevlge eiglpkrviq vwfqnarake kkaklqgtaa
     1081 gstggssegl laaqrtdcpy cdvkydfyvs crghlfsrqh laklkeavra qlkseskcyd
     1141 lapapeappa lkappattpa smplgaaptl prlapvllsg palaqpplgn lapfnsgpaa
     1201 ssgllglats vlptttvvqt agpgrplpqr pmpdqtntst agttdpvpgp pteplgdkvs
     1261 serkpvagpt sssndalknl kalkttvpal lggqflpfpl ppaggtappa vfgpqlqgay
     1321 fqqlygmkkg lfpmnpmipq tligllpnal lqpppqppep tatappkppe lpapgegeag
     1381 evdelltgst gistvdvthr ylcrqckmaf dgeapatahq rsfcffgrgs ggsmppplrv
     1441 pictyhclac evllsgreal ashlrssahr rkaappqggp pisitnaata asaavafake
     1501 earlphtdsn pkttttstll al
//
LOCUS       XP_016877207            1522 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger homeobox protein 2 isoform X7 [Homo sapiens].
ACCESSION   XP_016877207
VERSION     XP_016877207.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021718.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1522
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1522
                     /product="zinc finger homeobox protein 2 isoform X7"
                     /calculated_mol_wt=161578
     Region          143..165
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          200..218
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          545..602
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          719..741
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          808..864
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          1016..1072
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          <1157..1315
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          1403..1446
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275371"
     Site            order(1410..1412,1414..1415,1419,1445,1452,1455..1459,
                     1461..1462)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275371"
     Region          1447..1469
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275371"
     CDS             1..1522
                     /gene="ZFHX2"
                     /gene_synonym="MARSIS; ZFH-5; ZFH5; ZNF409"
                     /coded_by="XM_017021718.3:460..5028"
                     /db_xref="GeneID:85446"
                     /db_xref="HGNC:HGNC:20152"
                     /db_xref="MIM:617828"
ORIGIN      
        1 mtfttkvlsa ptlspldngq eppthgpept psrdqaaegp nltpeaspdp lpepplasve
       61 vpdkpsgspg qppspapspv pepdaqaedv appptmaeee egttgelrsa epapadsrhp
      121 ltyrkttnfa ldkfldparp ykctvckesf tqknillvhy nsvshlhkmk kaaidpsapa
      181 rgeagapptt taatdkpfkc tvcrvsynqs stleihmrsv lhqtrsrgtk tdskiegper
      241 sqeepkeget egevgtekkg pdtsgfisgl pflspppppl dlhrfpaplf tppvlppfpl
      301 vpesllklqq qqlllpfylh dlkvgpkltl agpapvlslp aatpppppqp pkaelaerew
      361 erppmakegn eagpssppdp lpneaartaa kallenfgfe lviqynegkq avpppptppp
      421 pealgggdkl acgacgklfs nmlilkthee hvhrrflpfe alsryaaqfr ksydslyppl
      481 aeppkppdgs ldspvphlgp pflvpepeag gtrapeersr agghwpieee essrgnlppl
      541 vpagrrfsrt kftefqtqal qsffetsayp kdgeverlas llglasrvvv vwfqnarqka
      601 rknaceggsm ptgggtggas gcrrchatfs cvfelvrhlk kcyddqtlee eeeeaergee
      661 eeeveeeeve eeqgleppag pegplpeppd geelsqaeat kaggkepeek atpspspaht
      721 cdqcaisfss qdlltshrrl hflpslqpsa ppqlldlpll vfgernplva atspmpgppl
      781 krkhedgsls ptgseagggg egepprdkrl rttilpeqle ilyrwymqds nptrkmldci
      841 seevglkkrv vqvwfqntra rerkgqfrst pggvpspavk ppatatpasl pkfnlllgkv
      901 ddgtgreapk reapafpypt atlasgpqpf lppgkeattp tpepplpllp ppppseeegp
      961 eeppkaspes eacslsagdl sdssasslae pespgaggts ggpgggtgvp dgmgqrryrt
     1021 qmsslqlkim kacyeayrtp tmqecevlge eiglpkrviq vwfqnarake kkaklqgtaa
     1081 gstggssegl laaqrtdcpy cdvkydfyvs crghlfsrqh laklkeavra qlkseskcyd
     1141 lapapeappa lkappattpa smplgaaptl prlapvllsg palaqpplgn lapfnsgpaa
     1201 ssgllglats vlptttvvqt agpgrplpqr pmpdqtntst agttdpvpgp pteplgdkvs
     1261 serkpvagpt sssndalknl kalkttvpal lggqflpfpl ppaggtappa vfgpqlqgay
     1321 fqqlygmkkg lfpmnpmipq tligllpnal lqpppqppep tatappkppe lpapgegeag
     1381 evdelltgst gistvdvthr ylcrqckmaf dgeapatahq rsfcffgrgs ggsmppplrv
     1441 pictyhclac evllsgreal ashlrssahr rkaappqggp pisitnaata asaavafake
     1501 earlphtdsn pkttttstll al
//
LOCUS       XP_047287783             462 aa            linear   PRI 05-AUG-2025
DEFINITION  corticosteroid-binding globulin isoform X1 [Homo sapiens].
ACCESSION   XP_047287783
VERSION     XP_047287783.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431827.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..462
                     /product="corticosteroid-binding globulin isoform X1"
                     /calculated_mol_wt=51301
     Region          33..461
                     /region_name="serpinA6_CBG"
                     /note="serpin family A member 6, corticosteroid-binding
                     globulin; cd19554"
                     /db_xref="CDD:381022"
     Site            order(40..41,44,311,319,321,339,342..343,346,445,447,450)
                     /site_type="other"
                     /note="cortisol binding site [polypeptide binding]"
                     /db_xref="CDD:381022"
     Site            order(414..431,433..439)
                     /site_type="other"
                     /note="reactive center loop (RCL)"
                     /db_xref="CDD:381022"
     CDS             1..462
                     /gene="SERPINA6"
                     /gene_synonym="CBG"
                     /coded_by="XM_047431827.1:90..1478"
                     /db_xref="GeneID:866"
                     /db_xref="HGNC:HGNC:1540"
                     /db_xref="MIM:122500"
ORIGIN      
        1 mplllytcll wlptsglwtv qamdpnaayv nmsnhhrgla sanvdfafsl ykhlvalspk
       61 knifispvsi smalamlslg tcghtraqll qglgfnlter seteihqgfq hlhqlfaksd
      121 tslemtmgna lfldgslell esfsadikhy yesevlamnf qdwatasrqi nsyvknktqg
      181 kivdlfsgld spailvlvny iffkgipthp hlkahplwpg itaakiqgtl lgkvfdsvkh
      241 ihiwespssp qscwtclllf lgtwtqpfdl astreenfyv dettvvkvpm mlqsstisyl
      301 hdselpcqlv qmnyvgngtv ffilpdkgkm ntviaalsrd tinrwsaglt ssqvdlyipk
      361 vtisgvydlg dvleemgiad lftnqanfsr itqdaqlkss kvvhkavlql neegvdtags
      421 tgvtlnltsk piilrfnqpf iimifdhftw sslflarvmn pv
//
LOCUS       XP_005268208             776 aa            linear   PRI 05-AUG-2025
DEFINITION  disintegrin and metalloproteinase domain-containing protein 20
            isoform X1 [Homo sapiens].
ACCESSION   XP_005268208
VERSION     XP_005268208.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005268151.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..776
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..776
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 20 isoform X1"
                     /calculated_mol_wt=86968
     Region          91..209
                     /region_name="Pep_M12B_propep"
                     /note="Reprolysin family propeptide; pfam01562"
                     /db_xref="CDD:460254"
     Region          257..446
                     /region_name="ZnMc_adamalysin_II_like"
                     /note="Zinc-dependent metalloprotease; adamalysin_II_like
                     subfamily. Adamalysin II is a snake venom zinc
                     endopeptidase. This subfamily contains other snake venom
                     metalloproteinases, as well as membrane-anchored
                     metalloproteases belonging to the ADAM family; cd04269"
                     /db_xref="CDD:239797"
     Site            order(392..393,396,402)
                     /site_type="active"
                     /db_xref="CDD:239797"
     Region          466..538
                     /region_name="Disintegrin"
                     /note="pfam00200"
                     /db_xref="CDD:459709"
     Region          542..678
                     /region_name="ACR"
                     /note="ADAM Cysteine-Rich Domain; smart00608"
                     /db_xref="CDD:214743"
     CDS             1..776
                     /gene="ADAM20"
                     /coded_by="XM_005268151.4:23852..26182"
                     /db_xref="GeneID:8748"
                     /db_xref="HGNC:HGNC:199"
                     /db_xref="MIM:603712"
ORIGIN      
        1 mvqlhqdtdp qipkgqpctl nsseggarpa vphtlfssal drwlhndsfi mavgeplvhi
       61 rvtllllwfg mflsisghsq arpsqyftsp evviplkvis rgrgakapgw lsyslrfggq
      121 ryivhmrvnk llfaahlpvf tyteqhallq dqpfiqddcy yhgyvegvpe slvalstcsg
      181 gflgmlqind lvyeikpisv satfehlvyk idsddtqfpp mrcglteeki ahqmelqlsy
      241 nftlkqssfv gwwthqrfve lvvvvdniry lfsqsnattv qhevfnvvni vdsfyhplev
      301 dviltgidiw tasnplptsg dldnvledfs iwknynlnnr lqhdvahlfi kdtqgmklgv
      361 ayvkgicqnp fntgvdvfed nrlvvfaitl ghelghnlgm qhdtqwcvce lqwcimhayr
      421 kvttkfsncs yaqywdstis sglciqpppy pgnifrlkyc gnlvveegee cdcgtirqca
      481 kdpccllnct lhpgaacafg icckdckflp sgtlcrqqvg ecdlpewcng tshqcpddvy
      541 vqdgiscnvn afcyektcnn hdiqckeifg qdarsasqsc yqeintqgnr fghcgivgtt
      601 yvkcwtpdim cgrvqcenvg vipnliehst vqqfhlndtt cwgtdyhlgm aipdigevkd
      661 gtvcgpekic irkkcasmvh lsqacqpktc nmrgicnnkq hchcnhewap pyckdkgygg
      721 sadsgpppkn nmeglnvmgk lrylsllcll plvafllfcl hvlfkkrtks kedeeg
//
LOCUS       XP_047287797             301 aa            linear   PRI 05-AUG-2025
DEFINITION  cyclin-dependent kinase-like 1 isoform X3 [Homo sapiens].
ACCESSION   XP_047287797
VERSION     XP_047287797.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431841.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..301
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..301
                     /product="cyclin-dependent kinase-like 1 isoform X3"
                     /calculated_mol_wt=34836
     Region          3..266
                     /region_name="STKc_CDKL1_4"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     Cyclin-Dependent protein Kinase Like 1 and 4; cd07847"
                     /db_xref="CDD:270837"
     Site            order(11..15,19,32,34,51,65,81..84,87,89..90,127,129,
                     131..132,134,145,148,160,162..165,167,205)
                     /site_type="active"
                     /db_xref="CDD:270837"
     Site            order(11..15,19,32,34,65,81..84,87,127,129,131..132,134,
                     145)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270837"
     Site            order(51,89,127,129,148,160,162..165,167,205)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270837"
     Site            order(144..156,158..167)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270837"
     CDS             1..301
                     /gene="CDKL1"
                     /gene_synonym="KKIALRE; P42"
                     /coded_by="XM_047431841.1:554..1459"
                     /db_xref="GeneID:8814"
                     /db_xref="HGNC:HGNC:1781"
                     /db_xref="MIM:603441"
ORIGIN      
        1 mmekyekigk igegsygvvf kcrnrdtgqi vaikkflese ddpvikkial reirmlkqlk
       61 hpnlvnllev frrkrrlhlv feycdhtvlh eldryqrgvp ehlvksitwq tlqavnfchk
      121 hncihrdvkp enilitkhsv iklcdfgfar lltgpsdyyt dyvatrwyrs pellvgdtqy
      181 gppvdvwaig cvfaellsgv plwpgksdvd qlylirktlg dliprhqqvf stnqyfsgvk
      241 ipdpedmepl elkfpnisyp algllklqyl pqltgssilp aldnkkyycd tkklnyrfpn
      301 i
//
LOCUS       XP_016877221             279 aa            linear   PRI 05-AUG-2025
DEFINITION  cyclin-dependent kinase-like 1 isoform X4 [Homo sapiens].
ACCESSION   XP_016877221
VERSION     XP_016877221.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021732.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..279
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..279
                     /product="cyclin-dependent kinase-like 1 isoform X4"
                     /calculated_mol_wt=32277
     Region          3..266
                     /region_name="STKc_CDKL1_4"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     Cyclin-Dependent protein Kinase Like 1 and 4; cd07847"
                     /db_xref="CDD:270837"
     Site            order(11..15,19,32,34,51,65,81..84,87,89..90,127,129,
                     131..132,134,145,148,160,162..165,167,205)
                     /site_type="active"
                     /db_xref="CDD:270837"
     Site            order(11..15,19,32,34,65,81..84,87,127,129,131..132,134,
                     145)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270837"
     Site            order(51,89,127,129,148,160,162..165,167,205)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270837"
     Site            order(144..156,158..167)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270837"
     CDS             1..279
                     /gene="CDKL1"
                     /gene_synonym="KKIALRE; P42"
                     /coded_by="XM_017021732.2:554..1393"
                     /db_xref="GeneID:8814"
                     /db_xref="HGNC:HGNC:1781"
                     /db_xref="MIM:603441"
ORIGIN      
        1 mmekyekigk igegsygvvf kcrnrdtgqi vaikkflese ddpvikkial reirmlkqlk
       61 hpnlvnllev frrkrrlhlv feycdhtvlh eldryqrgvp ehlvksitwq tlqavnfchk
      121 hncihrdvkp enilitkhsv iklcdfgfar lltgpsdyyt dyvatrwyrs pellvgdtqy
      181 gppvdvwaig cvfaellsgv plwpgksdvd qlylirktlg dliprhqqvf stnqyfsgvk
      241 ipdpedmepl elkfpnisyp algllkfhls kkkkmtlis
//
LOCUS       XP_005268217             244 aa            linear   PRI 05-AUG-2025
DEFINITION  cyclin-dependent kinase-like 1 isoform X6 [Homo sapiens].
ACCESSION   XP_005268217
VERSION     XP_005268217.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005268160.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..244
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..244
                     /product="cyclin-dependent kinase-like 1 isoform X6"
                     /calculated_mol_wt=28025
     Region          <9..174
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..244
                     /gene="CDKL1"
                     /gene_synonym="KKIALRE; P42"
                     /coded_by="XM_005268160.5:1875..2609"
                     /db_xref="GeneID:8814"
                     /db_xref="HGNC:HGNC:1781"
                     /db_xref="MIM:603441"
ORIGIN      
        1 miqaltgmci hrdvkpenil itkhsviklc dfgfarlltg psdyytdyva trwyrspell
       61 vgdtqygppv dvwaigcvfa ellsgvplwp gksdvdqlyl irktlgdlip rhqqvfstnq
      121 yfsgvkipdp edmeplelkf pnisypalgl lkgclhmdpt qrltceqllh hpyfenirei
      181 edlakehnkp trktlrksrk hhcftetskl qylpqltgss ilpaldnkky ycdtkklnyr
      241 fpni
//
LOCUS       XP_006720360             977 aa            linear   PRI 05-AUG-2025
DEFINITION  DDB1- and CUL4-associated factor 5 isoform X1 [Homo sapiens].
ACCESSION   XP_006720360
VERSION     XP_006720360.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720297.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..977
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..977
                     /product="DDB1- and CUL4-associated factor 5 isoform X1"
                     /calculated_mol_wt=107917
     Region          <49..250
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          57..98
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          104..139
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          146..187
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          191..228
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          280..358
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          362..396
                     /region_name="WD40"
                     /note="WD40 repeats; smart00320"
                     /db_xref="CDD:197651"
     Region          371..395
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..977
                     /gene="DCAF5"
                     /gene_synonym="BCRG2; BCRP2; D14S1461E; WDR22"
                     /coded_by="XM_006720297.3:220..3153"
                     /db_xref="GeneID:8816"
                     /db_xref="HGNC:HGNC:20224"
                     /db_xref="MIM:603812"
ORIGIN      
        1 mkrraglggs mrsvvgflsq rglhgdpllt qdfqrrrlrg crnlykkdll ghfgcvnaie
       61 fsnnggqwlv sggddrrvll whmeqaihsr vkpiqlkgeh hsnifclafn sgntkvfsgg
      121 ndeqvilhdv essetldvfa hedavyglsv spvndnifas ssddgrvliw diresphgep
      181 fclanypsaf hsvmfnpvep rllatanske gvglwdirkp qssllryggn lslqsamsvr
      241 fnsngtqlla lrrrlppvly dihsrlpvfq fdnqgyfnsc tmksccfagd rdqkpeaegk
      301 viffrlclat kpifmdlrrp rtktssqhyi lsgsddfnly mwripadpea ggigrvvnga
      361 fmvlkghrsi vnqvrfnpht ymicssgvek iikiwspykq pgctgdldgr ieddsrclyt
      421 heeyislvln sgsglshdya nqsvqedprm maffdslvrr eiegwssdsd sdlsestilq
      481 lhagvsersg ytdsessasl prsppptvde sadnafhlgp lrvtttntva stpptptced
      541 aasrqqrlsa lrryqdkrll alsnesdsee nvceveldtd lfprprspsp edesssssss
      601 sssedeeeln errastwqrn amrrrqkttr edkpsapikp tntyigedny dypqikvddl
      661 sssptssper ststleiqps rasptsdies verkiykayk wlrysyisys nnkdgetslv
      721 tgeadegrag tshkdnpaps sskeaclnia maqrnqdlpp egcskdtfke etprtpsngp
      781 ghehsshawa evpegtsqdt gnsgsvehpf etkklngkal ssraeeppsp pvpkasgstl
      841 nsgsgncprt qsddseersl eticanhnng rlhprpphph nngqnlgele vvaysspghs
      901 dtdrdnsslt gtllhkdccg semacetpna gtredptdtp atdssravhg hsglkrqrie
      961 ledtdsenss sekklkt
//
LOCUS       XP_006720361             976 aa            linear   PRI 05-AUG-2025
DEFINITION  DDB1- and CUL4-associated factor 5 isoform X2 [Homo sapiens].
ACCESSION   XP_006720361
VERSION     XP_006720361.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720298.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..976
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..976
                     /product="DDB1- and CUL4-associated factor 5 isoform X2"
                     /calculated_mol_wt=107830
     Region          <49..396
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          57..98
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          104..138
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          145..186
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          190..227
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          279..357
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          370..394
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..976
                     /gene="DCAF5"
                     /gene_synonym="BCRG2; BCRP2; D14S1461E; WDR22"
                     /coded_by="XM_006720298.3:220..3150"
                     /db_xref="GeneID:8816"
                     /db_xref="HGNC:HGNC:20224"
                     /db_xref="MIM:603812"
ORIGIN      
        1 mkrraglggs mrsvvgflsq rglhgdpllt qdfqrrrlrg crnlykkdll ghfgcvnaie
       61 fsnnggqwlv sggddrrvll whmeqaihsr vkpiqlkgeh hsnifclafn sgntkvfsgg
      121 ndeqvilhdv esetldvfah edavyglsvs pvndnifass sddgrvliwd iresphgepf
      181 clanypsafh svmfnpvepr llatanskeg vglwdirkpq ssllryggnl slqsamsvrf
      241 nsngtqllal rrrlppvlyd ihsrlpvfqf dnqgyfnsct mksccfagdr dqkpeaegkv
      301 iffrlclatk pifmdlrrpr tktssqhyil sgsddfnlym wripadpeag gigrvvngaf
      361 mvlkghrsiv nqvrfnphty micssgveki ikiwspykqp gctgdldgri eddsrclyth
      421 eeyislvlns gsglshdyan qsvqedprmm affdslvrre iegwssdsds dlsestilql
      481 hagvsersgy tdsessaslp rsppptvdes adnafhlgpl rvtttntvas tpptptceda
      541 asrqqrlsal rryqdkrlla lsnesdseen vceveldtdl fprprspspe dessssssss
      601 ssedeeelne rrastwqrna mrrrqkttre dkpsapikpt ntyigednyd ypqikvddls
      661 ssptsspers tstleiqpsr asptsdiesv erkiykaykw lrysyisysn nkdgetslvt
      721 geadegragt shkdnpapss skeaclniam aqrnqdlppe gcskdtfkee tprtpsngpg
      781 hehsshawae vpegtsqdtg nsgsvehpfe tkklngkals sraeeppspp vpkasgstln
      841 sgsgncprtq sddseersle ticanhnngr lhprpphphn ngqnlgelev vaysspghsd
      901 tdrdnssltg tllhkdccgs emacetpnag tredptdtpa tdssravhgh sglkrqriel
      961 edtdsensss ekklkt
//
LOCUS       XP_006720362             895 aa            linear   PRI 05-AUG-2025
DEFINITION  DDB1- and CUL4-associated factor 5 isoform X3 [Homo sapiens].
ACCESSION   XP_006720362
VERSION     XP_006720362.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720299.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..895
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..895
                     /product="DDB1- and CUL4-associated factor 5 isoform X3"
                     /calculated_mol_wt=98653
     Region          <10..315
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          22..58
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          64..103
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          108..150
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          155..190
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          195..233
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          241..276
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          289..313
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..895
                     /gene="DCAF5"
                     /gene_synonym="BCRG2; BCRP2; D14S1461E; WDR22"
                     /coded_by="XM_006720299.4:209..2896"
                     /db_xref="GeneID:8816"
                     /db_xref="HGNC:HGNC:20224"
                     /db_xref="MIM:603812"
ORIGIN      
        1 meqaihsrvk piqlkgehhs nifclafnsg ntkvfsggnd eqvilhdves setldvfahe
       61 davyglsvsp vndnifasss ddgrvliwdi resphgepfc lanypsafhs vmfnpveprl
      121 latanskegv glwdirkpqs sllryggnls lqsamsvrfn sngtqllalr rrlppvlydi
      181 hsrlpvfqfd nqgyfnsctm ksccfagdrd qkpeaegkvi ffrlclatkp ifmdlrrprt
      241 ktssqhyils gsddfnlymw ripadpeagg igrvvngafm vlkghrsivn qvrfnphtym
      301 icssgvekii kiwspykqpg ctgdldgrie ddsrclythe eyislvlnsg sglshdyanq
      361 svqedprmma ffdslvrrei egwssdsdsd lsestilqlh agvsersgyt dsessaslpr
      421 sppptvdesa dnafhlgplr vtttntvast pptptcedaa srqqrlsalr ryqdkrllal
      481 snesdseenv ceveldtdlf prprspsped esssssssss sedeeelner rastwqrnam
      541 rrrqkttred kpsapikptn tyigednydy pqikvddlss sptssperst stleiqpsra
      601 sptsdiesve rkiykaykwl rysyisysnn kdgetslvtg eadegragts hkdnpapsss
      661 keaclniama qrnqdlppeg cskdtfkeet prtpsngpgh ehsshawaev pegtsqdtgn
      721 sgsvehpfet kklngkalss raeeppsppv pkasgstlns gsgncprtqs ddseerslet
      781 icanhnngrl hprpphphnn gqnlgelevv aysspghsdt drdnssltgt llhkdccgse
      841 macetpnagt redptdtpat dssravhghs glkrqriele dtdsenssse kklkt
//
LOCUS       XP_011535581             895 aa            linear   PRI 05-AUG-2025
DEFINITION  DDB1- and CUL4-associated factor 5 isoform X3 [Homo sapiens].
ACCESSION   XP_011535581
VERSION     XP_011535581.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537279.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..895
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..895
                     /product="DDB1- and CUL4-associated factor 5 isoform X3"
                     /calculated_mol_wt=98653
     Region          <10..315
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          22..58
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          64..103
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          108..150
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          155..190
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          195..233
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          241..276
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          289..313
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..895
                     /gene="DCAF5"
                     /gene_synonym="BCRG2; BCRP2; D14S1461E; WDR22"
                     /coded_by="XM_011537279.3:143..2830"
                     /db_xref="GeneID:8816"
                     /db_xref="HGNC:HGNC:20224"
                     /db_xref="MIM:603812"
ORIGIN      
        1 meqaihsrvk piqlkgehhs nifclafnsg ntkvfsggnd eqvilhdves setldvfahe
       61 davyglsvsp vndnifasss ddgrvliwdi resphgepfc lanypsafhs vmfnpveprl
      121 latanskegv glwdirkpqs sllryggnls lqsamsvrfn sngtqllalr rrlppvlydi
      181 hsrlpvfqfd nqgyfnsctm ksccfagdrd qkpeaegkvi ffrlclatkp ifmdlrrprt
      241 ktssqhyils gsddfnlymw ripadpeagg igrvvngafm vlkghrsivn qvrfnphtym
      301 icssgvekii kiwspykqpg ctgdldgrie ddsrclythe eyislvlnsg sglshdyanq
      361 svqedprmma ffdslvrrei egwssdsdsd lsestilqlh agvsersgyt dsessaslpr
      421 sppptvdesa dnafhlgplr vtttntvast pptptcedaa srqqrlsalr ryqdkrllal
      481 snesdseenv ceveldtdlf prprspsped esssssssss sedeeelner rastwqrnam
      541 rrrqkttred kpsapikptn tyigednydy pqikvddlss sptssperst stleiqpsra
      601 sptsdiesve rkiykaykwl rysyisysnn kdgetslvtg eadegragts hkdnpapsss
      661 keaclniama qrnqdlppeg cskdtfkeet prtpsngpgh ehsshawaev pegtsqdtgn
      721 sgsvehpfet kklngkalss raeeppsppv pkasgstlns gsgncprtqs ddseerslet
      781 icanhnngrl hprpphphnn gqnlgelevv aysspghsdt drdnssltgt llhkdccgse
      841 macetpnagt redptdtpat dssravhghs glkrqriele dtdsenssse kklkt
//
LOCUS       XP_016877222             895 aa            linear   PRI 05-AUG-2025
DEFINITION  DDB1- and CUL4-associated factor 5 isoform X3 [Homo sapiens].
ACCESSION   XP_016877222
VERSION     XP_016877222.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021733.2
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 3% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..895
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..895
                     /product="DDB1- and CUL4-associated factor 5 isoform X3"
                     /calculated_mol_wt=98653
     Region          <10..315
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          22..58
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          64..103
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          108..150
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          155..190
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          195..233
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          241..276
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          289..313
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..895
                     /gene="DCAF5"
                     /gene_synonym="BCRG2; BCRP2; D14S1461E; WDR22"
                     /coded_by="XM_017021733.2:219..2906"
                     /db_xref="GeneID:8816"
                     /db_xref="HGNC:HGNC:20224"
                     /db_xref="MIM:603812"
ORIGIN      
        1 meqaihsrvk piqlkgehhs nifclafnsg ntkvfsggnd eqvilhdves setldvfahe
       61 davyglsvsp vndnifasss ddgrvliwdi resphgepfc lanypsafhs vmfnpveprl
      121 latanskegv glwdirkpqs sllryggnls lqsamsvrfn sngtqllalr rrlppvlydi
      181 hsrlpvfqfd nqgyfnsctm ksccfagdrd qkpeaegkvi ffrlclatkp ifmdlrrprt
      241 ktssqhyils gsddfnlymw ripadpeagg igrvvngafm vlkghrsivn qvrfnphtym
      301 icssgvekii kiwspykqpg ctgdldgrie ddsrclythe eyislvlnsg sglshdyanq
      361 svqedprmma ffdslvrrei egwssdsdsd lsestilqlh agvsersgyt dsessaslpr
      421 sppptvdesa dnafhlgplr vtttntvast pptptcedaa srqqrlsalr ryqdkrllal
      481 snesdseenv ceveldtdlf prprspsped esssssssss sedeeelner rastwqrnam
      541 rrrqkttred kpsapikptn tyigednydy pqikvddlss sptssperst stleiqpsra
      601 sptsdiesve rkiykaykwl rysyisysnn kdgetslvtg eadegragts hkdnpapsss
      661 keaclniama qrnqdlppeg cskdtfkeet prtpsngpgh ehsshawaev pegtsqdtgn
      721 sgsvehpfet kklngkalss raeeppsppv pkasgstlns gsgncprtqs ddseerslet
      781 icanhnngrl hprpphphnn gqnlgelevv aysspghsdt drdnssltgt llhkdccgse
      841 macetpnagt redptdtpat dssravhghs glkrqriele dtdsenssse kklkt
//
LOCUS       XP_047287802             895 aa            linear   PRI 05-AUG-2025
DEFINITION  DDB1- and CUL4-associated factor 5 isoform X3 [Homo sapiens].
ACCESSION   XP_047287802
VERSION     XP_047287802.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431846.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..895
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..895
                     /product="DDB1- and CUL4-associated factor 5 isoform X3"
                     /calculated_mol_wt=98653
     Region          <10..315
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          22..58
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          64..103
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          108..150
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          155..190
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          195..233
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          241..276
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          289..313
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..895
                     /gene="DCAF5"
                     /gene_synonym="BCRG2; BCRP2; D14S1461E; WDR22"
                     /coded_by="XM_047431846.1:216..2903"
                     /db_xref="GeneID:8816"
                     /db_xref="HGNC:HGNC:20224"
                     /db_xref="MIM:603812"
ORIGIN      
        1 meqaihsrvk piqlkgehhs nifclafnsg ntkvfsggnd eqvilhdves setldvfahe
       61 davyglsvsp vndnifasss ddgrvliwdi resphgepfc lanypsafhs vmfnpveprl
      121 latanskegv glwdirkpqs sllryggnls lqsamsvrfn sngtqllalr rrlppvlydi
      181 hsrlpvfqfd nqgyfnsctm ksccfagdrd qkpeaegkvi ffrlclatkp ifmdlrrprt
      241 ktssqhyils gsddfnlymw ripadpeagg igrvvngafm vlkghrsivn qvrfnphtym
      301 icssgvekii kiwspykqpg ctgdldgrie ddsrclythe eyislvlnsg sglshdyanq
      361 svqedprmma ffdslvrrei egwssdsdsd lsestilqlh agvsersgyt dsessaslpr
      421 sppptvdesa dnafhlgplr vtttntvast pptptcedaa srqqrlsalr ryqdkrllal
      481 snesdseenv ceveldtdlf prprspsped esssssssss sedeeelner rastwqrnam
      541 rrrqkttred kpsapikptn tyigednydy pqikvddlss sptssperst stleiqpsra
      601 sptsdiesve rkiykaykwl rysyisysnn kdgetslvtg eadegragts hkdnpapsss
      661 keaclniama qrnqdlppeg cskdtfkeet prtpsngpgh ehsshawaev pegtsqdtgn
      721 sgsvehpfet kklngkalss raeeppsppv pkasgstlns gsgncprtqs ddseerslet
      781 icanhnngrl hprpphphnn gqnlgelevv aysspghsdt drdnssltgt llhkdccgse
      841 macetpnagt redptdtpat dssravhghs glkrqriele dtdsenssse kklkt
//
LOCUS       XP_011535580             895 aa            linear   PRI 05-AUG-2025
DEFINITION  DDB1- and CUL4-associated factor 5 isoform X3 [Homo sapiens].
ACCESSION   XP_011535580
VERSION     XP_011535580.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537278.2
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 15% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..895
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..895
                     /product="DDB1- and CUL4-associated factor 5 isoform X3"
                     /calculated_mol_wt=98653
     Region          <10..315
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          22..58
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          64..103
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          108..150
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          155..190
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          195..233
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          241..276
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          289..313
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..895
                     /gene="DCAF5"
                     /gene_synonym="BCRG2; BCRP2; D14S1461E; WDR22"
                     /coded_by="XM_011537278.2:539..3226"
                     /db_xref="GeneID:8816"
                     /db_xref="HGNC:HGNC:20224"
                     /db_xref="MIM:603812"
ORIGIN      
        1 meqaihsrvk piqlkgehhs nifclafnsg ntkvfsggnd eqvilhdves setldvfahe
       61 davyglsvsp vndnifasss ddgrvliwdi resphgepfc lanypsafhs vmfnpveprl
      121 latanskegv glwdirkpqs sllryggnls lqsamsvrfn sngtqllalr rrlppvlydi
      181 hsrlpvfqfd nqgyfnsctm ksccfagdrd qkpeaegkvi ffrlclatkp ifmdlrrprt
      241 ktssqhyils gsddfnlymw ripadpeagg igrvvngafm vlkghrsivn qvrfnphtym
      301 icssgvekii kiwspykqpg ctgdldgrie ddsrclythe eyislvlnsg sglshdyanq
      361 svqedprmma ffdslvrrei egwssdsdsd lsestilqlh agvsersgyt dsessaslpr
      421 sppptvdesa dnafhlgplr vtttntvast pptptcedaa srqqrlsalr ryqdkrllal
      481 snesdseenv ceveldtdlf prprspsped esssssssss sedeeelner rastwqrnam
      541 rrrqkttred kpsapikptn tyigednydy pqikvddlss sptssperst stleiqpsra
      601 sptsdiesve rkiykaykwl rysyisysnn kdgetslvtg eadegragts hkdnpapsss
      661 keaclniama qrnqdlppeg cskdtfkeet prtpsngpgh ehsshawaev pegtsqdtgn
      721 sgsvehpfet kklngkalss raeeppsppv pkasgstlns gsgncprtqs ddseerslet
      781 icanhnngrl hprpphphnn gqnlgelevv aysspghsdt drdnssltgt llhkdccgse
      841 macetpnagt redptdtpat dssravhghs glkrqriele dtdsenssse kklkt
//
LOCUS       XP_047287803             895 aa            linear   PRI 05-AUG-2025
DEFINITION  DDB1- and CUL4-associated factor 5 isoform X3 [Homo sapiens].
ACCESSION   XP_047287803
VERSION     XP_047287803.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431847.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 3% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..895
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..895
                     /product="DDB1- and CUL4-associated factor 5 isoform X3"
                     /calculated_mol_wt=98653
     Region          <10..315
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          22..58
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          64..103
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          108..150
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          155..190
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          195..233
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          241..276
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          289..313
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..895
                     /gene="DCAF5"
                     /gene_synonym="BCRG2; BCRP2; D14S1461E; WDR22"
                     /coded_by="XM_047431847.1:292..2979"
                     /db_xref="GeneID:8816"
                     /db_xref="HGNC:HGNC:20224"
                     /db_xref="MIM:603812"
ORIGIN      
        1 meqaihsrvk piqlkgehhs nifclafnsg ntkvfsggnd eqvilhdves setldvfahe
       61 davyglsvsp vndnifasss ddgrvliwdi resphgepfc lanypsafhs vmfnpveprl
      121 latanskegv glwdirkpqs sllryggnls lqsamsvrfn sngtqllalr rrlppvlydi
      181 hsrlpvfqfd nqgyfnsctm ksccfagdrd qkpeaegkvi ffrlclatkp ifmdlrrprt
      241 ktssqhyils gsddfnlymw ripadpeagg igrvvngafm vlkghrsivn qvrfnphtym
      301 icssgvekii kiwspykqpg ctgdldgrie ddsrclythe eyislvlnsg sglshdyanq
      361 svqedprmma ffdslvrrei egwssdsdsd lsestilqlh agvsersgyt dsessaslpr
      421 sppptvdesa dnafhlgplr vtttntvast pptptcedaa srqqrlsalr ryqdkrllal
      481 snesdseenv ceveldtdlf prprspsped esssssssss sedeeelner rastwqrnam
      541 rrrqkttred kpsapikptn tyigednydy pqikvddlss sptssperst stleiqpsra
      601 sptsdiesve rkiykaykwl rysyisysnn kdgetslvtg eadegragts hkdnpapsss
      661 keaclniama qrnqdlppeg cskdtfkeet prtpsngpgh ehsshawaev pegtsqdtgn
      721 sgsvehpfet kklngkalss raeeppsppv pkasgstlns gsgncprtqs ddseerslet
      781 icanhnngrl hprpphphnn gqnlgelevv aysspghsdt drdnssltgt llhkdccgse
      841 macetpnagt redptdtpat dssravhghs glkrqriele dtdsenssse kklkt
//
LOCUS       XP_011535582             760 aa            linear   PRI 05-AUG-2025
DEFINITION  DDB1- and CUL4-associated factor 5 isoform X4 [Homo sapiens].
ACCESSION   XP_011535582
VERSION     XP_011535582.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537280.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..760
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..760
                     /product="DDB1- and CUL4-associated factor 5 isoform X4"
                     /calculated_mol_wt=83896
     Region          <107..>217
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     CDS             1..760
                     /gene="DCAF5"
                     /gene_synonym="BCRG2; BCRP2; D14S1461E; WDR22"
                     /coded_by="XM_011537280.4:91..2373"
                     /db_xref="GeneID:8816"
                     /db_xref="HGNC:HGNC:20224"
                     /db_xref="MIM:603812"
ORIGIN      
        1 mwewgsllry ggnlslqsam svrfnsngtq llalrrrlpp vlydihsrlp vfqfdnqgyf
       61 nsctmksccf agdrdqkpea egkviffrlc latkpifmdl rrprtktssq hyilsgsddf
      121 nlymwripad peaggigrvv ngafmvlkgh rsivnqvrfn phtymicssg vekiikiwsp
      181 ykqpgctgdl dgrieddsrc lytheeyisl vlnsgsglsh dyanqsvqed prmmaffdsl
      241 vrreiegwss dsdsdlsest ilqlhagvse rsgytdsess aslprspppt vdesadnafh
      301 lgplrvtttn tvastpptpt cedaasrqqr lsalrryqdk rllalsnesd seenvcevel
      361 dtdlfprprs pspedessss ssssssedee elnerrastw qrnamrrrqk ttredkpsap
      421 ikptntyige dnydypqikv ddlsssptss perststlei qpsrasptsd iesverkiyk
      481 aykwlrysyi sysnnkdget slvtgeadeg ragtshkdnp apssskeacl niamaqrnqd
      541 lppegcskdt fkeetprtps ngpghehssh awaevpegts qdtgnsgsve hpfetkklng
      601 kalssraeep psppvpkasg stlnsgsgnc prtqsddsee rsleticanh nngrlhprpp
      661 hphnngqnlg elevvayssp ghsdtdrdns sltgtllhkd ccgsemacet pnagtredpt
      721 dtpatdssra vhghsglkrq rieledtdse nsssekklkt
//
LOCUS       XP_016877226             725 aa            linear   PRI 05-AUG-2025
DEFINITION  DDB1- and CUL4-associated factor 5 isoform X5 [Homo sapiens].
ACCESSION   XP_016877226
VERSION     XP_016877226.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021737.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..725
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..725
                     /product="DDB1- and CUL4-associated factor 5 isoform X5"
                     /calculated_mol_wt=79811
     Region          21..55
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          61..114
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          <67..186
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     CDS             1..725
                     /gene="DCAF5"
                     /gene_synonym="BCRG2; BCRP2; D14S1461E; WDR22"
                     /coded_by="XM_017021737.2:166..2343"
                     /db_xref="GeneID:8816"
                     /db_xref="HGNC:HGNC:20224"
                     /db_xref="MIM:603812"
ORIGIN      
        1 mwewgsllry ggnlslqsam svrfnsngtq llalrrrlpp vlydihsrlp vfqfdnqgyf
       61 nsctmksccf agdrdqyils gsddfnlymw ripadpeagg igrvvngafm vlkghrsivn
      121 qvrfnphtym icssgvekii kiwspykqpg ctgdldgrie ddsrclythe eyislvlnsg
      181 sglshdyanq svqedprmma ffdslvrrei egwssdsdsd lsestilqlh agvsersgyt
      241 dsessaslpr sppptvdesa dnafhlgplr vtttntvast pptptcedaa srqqrlsalr
      301 ryqdkrllal snesdseenv ceveldtdlf prprspsped esssssssss sedeeelner
      361 rastwqrnam rrrqkttred kpsapikptn tyigednydy pqikvddlss sptssperst
      421 stleiqpsra sptsdiesve rkiykaykwl rysyisysnn kdgetslvtg eadegragts
      481 hkdnpapsss keaclniama qrnqdlppeg cskdtfkeet prtpsngpgh ehsshawaev
      541 pegtsqdtgn sgsvehpfet kklngkalss raeeppsppv pkasgstlns gsgncprtqs
      601 ddseerslet icanhnngrl hprpphphnn gqnlgelevv aysspghsdt drdnssltgt
      661 llhkdccgse macetpnagt redptdtpat dssravhghs glkrqriele dtdsenssse
      721 kklkt
//
LOCUS       XP_047287804             184 aa            linear   PRI 05-AUG-2025
DEFINITION  nucleic acid dioxygenase ALKBH1 isoform X1 [Homo sapiens].
ACCESSION   XP_047287804
VERSION     XP_047287804.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431848.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..184
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..184
                     /product="nucleic acid dioxygenase ALKBH1 isoform X1"
                     /calculated_mol_wt=20873
     Region          119..>182
                     /region_name="2OG-FeII_Oxy"
                     /note="2OG-Fe(II) oxygenase superfamily; cl21496"
                     /db_xref="CDD:473886"
     CDS             1..184
                     /gene="ALKBH1"
                     /gene_synonym="ABH; ABH1; alkB; ALKBH; hABH"
                     /coded_by="XM_047431848.1:20..574"
                     /db_xref="GeneID:8846"
                     /db_xref="HGNC:HGNC:17911"
                     /db_xref="MIM:605345"
ORIGIN      
        1 mgkmaaavgs vatlatepge dafrklfrfy rqsrpgtadl egvidfsaah aargkgpgaq
       61 kviksqlnvs svseqnayra glqpvskwqa yglkgypgfi fipnpflpgy qwhwvkqclk
      121 lysqkpnvcn ldkhmskeet qdlweqskef lrykeatkrr prslleklrw vtvgyhynwd
      181 sksk
//
LOCUS       XP_047287805             876 aa            linear   PRI 05-AUG-2025
DEFINITION  AP-1 complex subunit gamma-like 2 isoform X1 [Homo sapiens].
ACCESSION   XP_047287805
VERSION     XP_047287805.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431849.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 7% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..876
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..876
                     /product="AP-1 complex subunit gamma-like 2 isoform X1"
                     /calculated_mol_wt=97169
     Region          58..666
                     /region_name="Adaptin_N"
                     /note="Adaptin N terminal region; pfam01602"
                     /db_xref="CDD:396262"
     Region          763..871
                     /region_name="Alpha_adaptinC2"
                     /note="Adaptin C-terminal domain; smart00809"
                     /db_xref="CDD:197886"
     CDS             1..876
                     /gene="AP1G2"
                     /gene_synonym="G2AD"
                     /coded_by="XM_047431849.1:241..2871"
                     /db_xref="GeneID:8906"
                     /db_xref="HGNC:HGNC:556"
                     /db_xref="MIM:603534"
ORIGIN      
        1 mlnrkgrrwg adacvvgfsg ggvgaefgdp lrermvvpsl klqdlieeir gaktqaqere
       61 viqkecahir asfrdgdpvh rhrqlaklly vhmlgypahf gqmeclklia ssrftdkrvg
      121 ylgamlllde rhdahllitn sikndlsqgi qpvqglalct lstmgsaemc rdlapevekl
      181 llqpspyvrk kailtavhmi rkvpelssvf lppcaqllhe rhhgkavgpp ilcfrsmdrr
      241 ienrmgtpah rrrvvhthrh trnrlscpwp ppftsptltp gillgtitli telcerspaa
      301 lrhfrkvvpq lvhilrtlvt mgystehsis gvsdpflqvq ilrllrilgr nheessetmn
      361 dllaqvatnt dtsrnagnav lfetvltimd irsaaglrvl avnilgrfll nsdrniryva
      421 ltsllrlvqs dhsavqrhrp tvveclretd aslsrralel slalvnssnv rammqelqaf
      481 lescppdlra dcasgillaa erfaptkrwh idtilhvltt agthvrddav anltqligga
      541 qelhaysvrr lynalaedis qqplvqvaaw cigeygdlll agnceeiepl qvdeeevlal
      601 lekvlqshms lpatrgyalt almklstrlc gdnnrirqvv siygscldve lqqraveydt
      661 lfrkydhmra ailekmplve rdgpqadeea keskeaaqls eaapvptepq asqlldlldl
      721 ldgasgdvqh pphldpspgg alvhlldlpc vppppapipd lkvferegvq lnlsfirppe
      781 npalllitit atnfsegdvt hficqaavpk slqlqlqaps gntvparggl pitqlfriln
      841 pnkaplrlkl rltydhfhqs vqeifevnnl pveswq
//
LOCUS       XP_005268224             842 aa            linear   PRI 05-AUG-2025
DEFINITION  AP-1 complex subunit gamma-like 2 isoform X2 [Homo sapiens].
ACCESSION   XP_005268224
VERSION     XP_005268224.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005268167.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..842
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..842
                     /product="AP-1 complex subunit gamma-like 2 isoform X2"
                     /calculated_mol_wt=93565
     Region          24..632
                     /region_name="Adaptin_N"
                     /note="Adaptin N terminal region; pfam01602"
                     /db_xref="CDD:396262"
     Region          729..837
                     /region_name="Alpha_adaptinC2"
                     /note="Adaptin C-terminal domain; smart00809"
                     /db_xref="CDD:197886"
     CDS             1..842
                     /gene="AP1G2"
                     /gene_synonym="G2AD"
                     /coded_by="XM_005268167.4:59..2587"
                     /db_xref="GeneID:8906"
                     /db_xref="HGNC:HGNC:556"
                     /db_xref="MIM:603534"
ORIGIN      
        1 mvvpslklqd lieeirgakt qaqereviqk ecahirasfr dgdpvhrhrq lakllyvhml
       61 gypahfgqme clkliassrf tdkrvgylga mlllderhda hllitnsikn dlsqgiqpvq
      121 glalctlstm gsaemcrdla peveklllqp spyvrkkail tavhmirkvp elssvflppc
      181 aqllherhhg kavgppilcf rsmdrrienr mgtpahrrrv vhthrhtrnr lscpwpppft
      241 sptltpgill gtitlitelc erspaalrhf rkvvpqlvhi lrtlvtmgys tehsisgvsd
      301 pflqvqilrl lrilgrnhee ssetmndlla qvatntdtsr nagnavlfet vltimdirsa
      361 aglrvlavni lgrfllnsdr niryvaltsl lrlvqsdhsa vqrhrptvve clretdasls
      421 rralelslal vnssnvramm qelqaflesc ppdlradcas gillaaerfa ptkrwhidti
      481 lhvlttagth vrddavanlt qliggaqelh aysvrrlyna laedisqqpl vqvaawcige
      541 ygdlllagnc eeieplqvde eevlallekv lqshmslpat rgyaltalmk lstrlcgdnn
      601 rirqvvsiyg scldvelqqr aveydtlfrk ydhmraaile kmplverdgp qadeeakesk
      661 eaaqlseaap vptepqasql ldlldlldga sgdvqhpphl dpspggalvh lldlpcvppp
      721 papipdlkvf eregvqlnls firppenpal llititatnf segdvthfic qaavpkslql
      781 qlqapsgntv pargglpitq lfrilnpnka plrlklrlty dhfhqsvqei fevnnlpves
      841 wq
//
LOCUS       XP_005268225             842 aa            linear   PRI 05-AUG-2025
DEFINITION  AP-1 complex subunit gamma-like 2 isoform X2 [Homo sapiens].
ACCESSION   XP_005268225
VERSION     XP_005268225.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005268168.6
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..842
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..842
                     /product="AP-1 complex subunit gamma-like 2 isoform X2"
                     /calculated_mol_wt=93565
     Region          24..632
                     /region_name="Adaptin_N"
                     /note="Adaptin N terminal region; pfam01602"
                     /db_xref="CDD:396262"
     Region          729..837
                     /region_name="Alpha_adaptinC2"
                     /note="Adaptin C-terminal domain; smart00809"
                     /db_xref="CDD:197886"
     CDS             1..842
                     /gene="AP1G2"
                     /gene_synonym="G2AD"
                     /coded_by="XM_005268168.6:201..2729"
                     /db_xref="GeneID:8906"
                     /db_xref="HGNC:HGNC:556"
                     /db_xref="MIM:603534"
ORIGIN      
        1 mvvpslklqd lieeirgakt qaqereviqk ecahirasfr dgdpvhrhrq lakllyvhml
       61 gypahfgqme clkliassrf tdkrvgylga mlllderhda hllitnsikn dlsqgiqpvq
      121 glalctlstm gsaemcrdla peveklllqp spyvrkkail tavhmirkvp elssvflppc
      181 aqllherhhg kavgppilcf rsmdrrienr mgtpahrrrv vhthrhtrnr lscpwpppft
      241 sptltpgill gtitlitelc erspaalrhf rkvvpqlvhi lrtlvtmgys tehsisgvsd
      301 pflqvqilrl lrilgrnhee ssetmndlla qvatntdtsr nagnavlfet vltimdirsa
      361 aglrvlavni lgrfllnsdr niryvaltsl lrlvqsdhsa vqrhrptvve clretdasls
      421 rralelslal vnssnvramm qelqaflesc ppdlradcas gillaaerfa ptkrwhidti
      481 lhvlttagth vrddavanlt qliggaqelh aysvrrlyna laedisqqpl vqvaawcige
      541 ygdlllagnc eeieplqvde eevlallekv lqshmslpat rgyaltalmk lstrlcgdnn
      601 rirqvvsiyg scldvelqqr aveydtlfrk ydhmraaile kmplverdgp qadeeakesk
      661 eaaqlseaap vptepqasql ldlldlldga sgdvqhpphl dpspggalvh lldlpcvppp
      721 papipdlkvf eregvqlnls firppenpal llititatnf segdvthfic qaavpkslql
      781 qlqapsgntv pargglpitq lfrilnpnka plrlklrlty dhfhqsvqei fevnnlpves
      841 wq
//
LOCUS       XP_005268227             842 aa            linear   PRI 05-AUG-2025
DEFINITION  AP-1 complex subunit gamma-like 2 isoform X2 [Homo sapiens].
ACCESSION   XP_005268227
VERSION     XP_005268227.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005268170.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..842
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..842
                     /product="AP-1 complex subunit gamma-like 2 isoform X2"
                     /calculated_mol_wt=93565
     Region          24..632
                     /region_name="Adaptin_N"
                     /note="Adaptin N terminal region; pfam01602"
                     /db_xref="CDD:396262"
     Region          729..837
                     /region_name="Alpha_adaptinC2"
                     /note="Adaptin C-terminal domain; smart00809"
                     /db_xref="CDD:197886"
     CDS             1..842
                     /gene="AP1G2"
                     /gene_synonym="G2AD"
                     /coded_by="XM_005268170.4:55..2583"
                     /db_xref="GeneID:8906"
                     /db_xref="HGNC:HGNC:556"
                     /db_xref="MIM:603534"
ORIGIN      
        1 mvvpslklqd lieeirgakt qaqereviqk ecahirasfr dgdpvhrhrq lakllyvhml
       61 gypahfgqme clkliassrf tdkrvgylga mlllderhda hllitnsikn dlsqgiqpvq
      121 glalctlstm gsaemcrdla peveklllqp spyvrkkail tavhmirkvp elssvflppc
      181 aqllherhhg kavgppilcf rsmdrrienr mgtpahrrrv vhthrhtrnr lscpwpppft
      241 sptltpgill gtitlitelc erspaalrhf rkvvpqlvhi lrtlvtmgys tehsisgvsd
      301 pflqvqilrl lrilgrnhee ssetmndlla qvatntdtsr nagnavlfet vltimdirsa
      361 aglrvlavni lgrfllnsdr niryvaltsl lrlvqsdhsa vqrhrptvve clretdasls
      421 rralelslal vnssnvramm qelqaflesc ppdlradcas gillaaerfa ptkrwhidti
      481 lhvlttagth vrddavanlt qliggaqelh aysvrrlyna laedisqqpl vqvaawcige
      541 ygdlllagnc eeieplqvde eevlallekv lqshmslpat rgyaltalmk lstrlcgdnn
      601 rirqvvsiyg scldvelqqr aveydtlfrk ydhmraaile kmplverdgp qadeeakesk
      661 eaaqlseaap vptepqasql ldlldlldga sgdvqhpphl dpspggalvh lldlpcvppp
      721 papipdlkvf eregvqlnls firppenpal llititatnf segdvthfic qaavpkslql
      781 qlqapsgntv pargglpitq lfrilnpnka plrlklrlty dhfhqsvqei fevnnlpves
      841 wq
//
LOCUS       XP_005268226             842 aa            linear   PRI 05-AUG-2025
DEFINITION  AP-1 complex subunit gamma-like 2 isoform X2 [Homo sapiens].
ACCESSION   XP_005268226
VERSION     XP_005268226.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005268169.4
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 10% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..842
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..842
                     /product="AP-1 complex subunit gamma-like 2 isoform X2"
                     /calculated_mol_wt=93565
     Region          24..632
                     /region_name="Adaptin_N"
                     /note="Adaptin N terminal region; pfam01602"
                     /db_xref="CDD:396262"
     Region          729..837
                     /region_name="Alpha_adaptinC2"
                     /note="Adaptin C-terminal domain; smart00809"
                     /db_xref="CDD:197886"
     CDS             1..842
                     /gene="AP1G2"
                     /gene_synonym="G2AD"
                     /coded_by="XM_005268169.4:347..2875"
                     /db_xref="GeneID:8906"
                     /db_xref="HGNC:HGNC:556"
                     /db_xref="MIM:603534"
ORIGIN      
        1 mvvpslklqd lieeirgakt qaqereviqk ecahirasfr dgdpvhrhrq lakllyvhml
       61 gypahfgqme clkliassrf tdkrvgylga mlllderhda hllitnsikn dlsqgiqpvq
      121 glalctlstm gsaemcrdla peveklllqp spyvrkkail tavhmirkvp elssvflppc
      181 aqllherhhg kavgppilcf rsmdrrienr mgtpahrrrv vhthrhtrnr lscpwpppft
      241 sptltpgill gtitlitelc erspaalrhf rkvvpqlvhi lrtlvtmgys tehsisgvsd
      301 pflqvqilrl lrilgrnhee ssetmndlla qvatntdtsr nagnavlfet vltimdirsa
      361 aglrvlavni lgrfllnsdr niryvaltsl lrlvqsdhsa vqrhrptvve clretdasls
      421 rralelslal vnssnvramm qelqaflesc ppdlradcas gillaaerfa ptkrwhidti
      481 lhvlttagth vrddavanlt qliggaqelh aysvrrlyna laedisqqpl vqvaawcige
      541 ygdlllagnc eeieplqvde eevlallekv lqshmslpat rgyaltalmk lstrlcgdnn
      601 rirqvvsiyg scldvelqqr aveydtlfrk ydhmraaile kmplverdgp qadeeakesk
      661 eaaqlseaap vptepqasql ldlldlldga sgdvqhpphl dpspggalvh lldlpcvppp
      721 papipdlkvf eregvqlnls firppenpal llititatnf segdvthfic qaavpkslql
      781 qlqapsgntv pargglpitq lfrilnpnka plrlklrlty dhfhqsvqei fevnnlpves
      841 wq
//
LOCUS       XP_006720364             842 aa            linear   PRI 05-AUG-2025
DEFINITION  AP-1 complex subunit gamma-like 2 isoform X2 [Homo sapiens].
ACCESSION   XP_006720364
VERSION     XP_006720364.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720301.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..842
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..842
                     /product="AP-1 complex subunit gamma-like 2 isoform X2"
                     /calculated_mol_wt=93565
     Region          24..632
                     /region_name="Adaptin_N"
                     /note="Adaptin N terminal region; pfam01602"
                     /db_xref="CDD:396262"
     Region          729..837
                     /region_name="Alpha_adaptinC2"
                     /note="Adaptin C-terminal domain; smart00809"
                     /db_xref="CDD:197886"
     CDS             1..842
                     /gene="AP1G2"
                     /gene_synonym="G2AD"
                     /coded_by="XM_006720301.4:197..2725"
                     /db_xref="GeneID:8906"
                     /db_xref="HGNC:HGNC:556"
                     /db_xref="MIM:603534"
ORIGIN      
        1 mvvpslklqd lieeirgakt qaqereviqk ecahirasfr dgdpvhrhrq lakllyvhml
       61 gypahfgqme clkliassrf tdkrvgylga mlllderhda hllitnsikn dlsqgiqpvq
      121 glalctlstm gsaemcrdla peveklllqp spyvrkkail tavhmirkvp elssvflppc
      181 aqllherhhg kavgppilcf rsmdrrienr mgtpahrrrv vhthrhtrnr lscpwpppft
      241 sptltpgill gtitlitelc erspaalrhf rkvvpqlvhi lrtlvtmgys tehsisgvsd
      301 pflqvqilrl lrilgrnhee ssetmndlla qvatntdtsr nagnavlfet vltimdirsa
      361 aglrvlavni lgrfllnsdr niryvaltsl lrlvqsdhsa vqrhrptvve clretdasls
      421 rralelslal vnssnvramm qelqaflesc ppdlradcas gillaaerfa ptkrwhidti
      481 lhvlttagth vrddavanlt qliggaqelh aysvrrlyna laedisqqpl vqvaawcige
      541 ygdlllagnc eeieplqvde eevlallekv lqshmslpat rgyaltalmk lstrlcgdnn
      601 rirqvvsiyg scldvelqqr aveydtlfrk ydhmraaile kmplverdgp qadeeakesk
      661 eaaqlseaap vptepqasql ldlldlldga sgdvqhpphl dpspggalvh lldlpcvppp
      721 papipdlkvf eregvqlnls firppenpal llititatnf segdvthfic qaavpkslql
      781 qlqapsgntv pargglpitq lfrilnpnka plrlklrlty dhfhqsvqei fevnnlpves
      841 wq
//
LOCUS       XP_011535585             841 aa            linear   PRI 05-AUG-2025
DEFINITION  AP-1 complex subunit gamma-like 2 isoform X3 [Homo sapiens].
ACCESSION   XP_011535585
VERSION     XP_011535585.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537283.4
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XP_011535585.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 7% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..841
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..841
                     /product="AP-1 complex subunit gamma-like 2 isoform X3"
                     /calculated_mol_wt=92912
     Region          58..634
                     /region_name="Adaptin_N"
                     /note="Adaptin N terminal region; pfam01602"
                     /db_xref="CDD:396262"
     Region          728..836
                     /region_name="Alpha_adaptinC2"
                     /note="Adaptin C-terminal domain; smart00809"
                     /db_xref="CDD:197886"
     CDS             1..841
                     /gene="AP1G2"
                     /gene_synonym="G2AD"
                     /coded_by="XM_011537283.4:241..2766"
                     /db_xref="GeneID:8906"
                     /db_xref="HGNC:HGNC:556"
                     /db_xref="MIM:603534"
ORIGIN      
        1 mlnrkgrrwg adacvvgfsg ggvgaefgdp lrermvvpsl klqdlieeir gaktqaqere
       61 viqkecahir asfrdgdpvh rhrqlaklly vhmlgypahf gqmeclklia ssrftdkrvg
      121 ylgamlllde rhdahllitn sikndlsqgi qpvqglalct lstmgsaemc rdlapevekl
      181 llqpspyvrk kailtavhmi rkvpelssvf lppcaqllhe rhhgkavgpp ilcfrsmdrr
      241 ienrmgtpah rrrvvhthrh trnrlscpwp ppftsptltp gillgtitli telcerspaa
      301 lrhfrkvvpq lvhilrtlvt mgystehsis gvsdpflqvq ilrllrilgr nheessetmn
      361 dllaqvatnt dtsrnagnav lfetvltimd irsaaglrvl avnilgrfll nsdrniryva
      421 ltsllrlvqs dhsavqrhrp tvveclretd aslsrralel slalvnssnv rammqelqaf
      481 lescppdlra dcasgillaa erfaptkrwh idtilhvltt agthvrddav anltqligga
      541 qelhaysvrr lynalaedis qqplvqvaaw cigeygdlll agnceeiepl qvdeeevlal
      601 lekvlqshms lpatrgyalt almklstrlc gdnkaailek mplverdgpq adeeakeske
      661 aaqlseaapv ptepqasqll dlldlldgas gdvqhpphld pspggalvhl ldlpcvpppp
      721 apipdlkvfe regvqlnlsf irppenpall lititatnfs egdvthficq aavpkslqlq
      781 lqapsgntvp argglpitql frilnpnkap lrlklrltyd hfhqsvqeif evnnlpvesw
      841 q
//
LOCUS       XP_047287806             819 aa            linear   PRI 05-AUG-2025
DEFINITION  AP-1 complex subunit gamma-like 2 isoform X4 [Homo sapiens].
ACCESSION   XP_047287806
VERSION     XP_047287806.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431850.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 8% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..819
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..819
                     /product="AP-1 complex subunit gamma-like 2 isoform X4"
                     /calculated_mol_wt=90590
     Region          58..609
                     /region_name="Adaptin_N"
                     /note="Adaptin N terminal region; pfam01602"
                     /db_xref="CDD:396262"
     Region          706..814
                     /region_name="Alpha_adaptinC2"
                     /note="Adaptin C-terminal domain; smart00809"
                     /db_xref="CDD:197886"
     CDS             1..819
                     /gene="AP1G2"
                     /gene_synonym="G2AD"
                     /coded_by="XM_047431850.1:241..2700"
                     /db_xref="GeneID:8906"
                     /db_xref="HGNC:HGNC:556"
                     /db_xref="MIM:603534"
ORIGIN      
        1 mlnrkgrrwg adacvvgfsg ggvgaefgdp lrermvvpsl klqdlieeir gaktqaqere
       61 viqkecahir asfrdgdpvh rhrqlaklly vhmlgypahf gqmeclklia ssrftdkrvg
      121 ylgamlllde rhdahllitn sikndlsqgi qpvqglalct lstmgsaemc rdlapevekl
      181 llqpspyvrk kailtavhmi rkvpelssvf lppcaqllhe rhhgillgti tlitelcers
      241 paalrhfrkv vpqlvhilrt lvtmgysteh sisgvsdpfl qvqilrllri lgrnheesse
      301 tmndllaqva tntdtsrnag navlfetvlt imdirsaagl rvlavnilgr fllnsdrnir
      361 yvaltsllrl vqsdhsavqr hrptvveclr etdaslsrra lelslalvns snvrammqel
      421 qaflescppd lradcasgil laaerfaptk rwhidtilhv lttagthvrd davanltqli
      481 ggaqelhays vrrlynalae disqqplvqv aawcigeygd lllagnceei eplqvdeeev
      541 lallekvlqs hmslpatrgy altalmklst rlcgdnnrir qvvsiygscl dvelqqrave
      601 ydtlfrkydh mraailekmp lverdgpqad eeakeskeaa qlseaapvpt epqasqlldl
      661 ldlldgasgd vqhpphldps pggalvhlld lpcvppppap ipdlkvfere gvqlnlsfir
      721 ppenpallli titatnfseg dvthficqaa vpkslqlqlq apsgntvpar gglpitqlfr
      781 ilnpnkaplr lklrltydhf hqsvqeifev nnlpveswq
//
LOCUS       XP_047287807             807 aa            linear   PRI 05-AUG-2025
DEFINITION  AP-1 complex subunit gamma-like 2 isoform X5 [Homo sapiens].
ACCESSION   XP_047287807
VERSION     XP_047287807.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431851.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..807
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..807
                     /product="AP-1 complex subunit gamma-like 2 isoform X5"
                     /calculated_mol_wt=89308
     Region          24..600
                     /region_name="Adaptin_N"
                     /note="Adaptin N terminal region; pfam01602"
                     /db_xref="CDD:396262"
     Region          694..802
                     /region_name="Alpha_adaptinC2"
                     /note="Adaptin C-terminal domain; smart00809"
                     /db_xref="CDD:197886"
     CDS             1..807
                     /gene="AP1G2"
                     /gene_synonym="G2AD"
                     /coded_by="XM_047431851.1:59..2482"
                     /db_xref="GeneID:8906"
                     /db_xref="HGNC:HGNC:556"
                     /db_xref="MIM:603534"
ORIGIN      
        1 mvvpslklqd lieeirgakt qaqereviqk ecahirasfr dgdpvhrhrq lakllyvhml
       61 gypahfgqme clkliassrf tdkrvgylga mlllderhda hllitnsikn dlsqgiqpvq
      121 glalctlstm gsaemcrdla peveklllqp spyvrkkail tavhmirkvp elssvflppc
      181 aqllherhhg kavgppilcf rsmdrrienr mgtpahrrrv vhthrhtrnr lscpwpppft
      241 sptltpgill gtitlitelc erspaalrhf rkvvpqlvhi lrtlvtmgys tehsisgvsd
      301 pflqvqilrl lrilgrnhee ssetmndlla qvatntdtsr nagnavlfet vltimdirsa
      361 aglrvlavni lgrfllnsdr niryvaltsl lrlvqsdhsa vqrhrptvve clretdasls
      421 rralelslal vnssnvramm qelqaflesc ppdlradcas gillaaerfa ptkrwhidti
      481 lhvlttagth vrddavanlt qliggaqelh aysvrrlyna laedisqqpl vqvaawcige
      541 ygdlllagnc eeieplqvde eevlallekv lqshmslpat rgyaltalmk lstrlcgdnk
      601 aailekmplv erdgpqadee akeskeaaql seaapvptep qasqlldlld lldgasgdvq
      661 hpphldpspg galvhlldlp cvppppapip dlkvferegv qlnlsfirpp enpallliti
      721 tatnfsegdv thficqaavp kslqlqlqap sgntvpargg lpitqlfril npnkaplrlk
      781 lrltydhfhq svqeifevnn lpveswq
//
LOCUS       XP_047287808             807 aa            linear   PRI 05-AUG-2025
DEFINITION  AP-1 complex subunit gamma-like 2 isoform X5 [Homo sapiens].
ACCESSION   XP_047287808
VERSION     XP_047287808.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431852.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..807
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..807
                     /product="AP-1 complex subunit gamma-like 2 isoform X5"
                     /calculated_mol_wt=89308
     Region          24..600
                     /region_name="Adaptin_N"
                     /note="Adaptin N terminal region; pfam01602"
                     /db_xref="CDD:396262"
     Region          694..802
                     /region_name="Alpha_adaptinC2"
                     /note="Adaptin C-terminal domain; smart00809"
                     /db_xref="CDD:197886"
     CDS             1..807
                     /gene="AP1G2"
                     /gene_synonym="G2AD"
                     /coded_by="XM_047431852.1:201..2624"
                     /db_xref="GeneID:8906"
                     /db_xref="HGNC:HGNC:556"
                     /db_xref="MIM:603534"
ORIGIN      
        1 mvvpslklqd lieeirgakt qaqereviqk ecahirasfr dgdpvhrhrq lakllyvhml
       61 gypahfgqme clkliassrf tdkrvgylga mlllderhda hllitnsikn dlsqgiqpvq
      121 glalctlstm gsaemcrdla peveklllqp spyvrkkail tavhmirkvp elssvflppc
      181 aqllherhhg kavgppilcf rsmdrrienr mgtpahrrrv vhthrhtrnr lscpwpppft
      241 sptltpgill gtitlitelc erspaalrhf rkvvpqlvhi lrtlvtmgys tehsisgvsd
      301 pflqvqilrl lrilgrnhee ssetmndlla qvatntdtsr nagnavlfet vltimdirsa
      361 aglrvlavni lgrfllnsdr niryvaltsl lrlvqsdhsa vqrhrptvve clretdasls
      421 rralelslal vnssnvramm qelqaflesc ppdlradcas gillaaerfa ptkrwhidti
      481 lhvlttagth vrddavanlt qliggaqelh aysvrrlyna laedisqqpl vqvaawcige
      541 ygdlllagnc eeieplqvde eevlallekv lqshmslpat rgyaltalmk lstrlcgdnk
      601 aailekmplv erdgpqadee akeskeaaql seaapvptep qasqlldlld lldgasgdvq
      661 hpphldpspg galvhlldlp cvppppapip dlkvferegv qlnlsfirpp enpallliti
      721 tatnfsegdv thficqaavp kslqlqlqap sgntvpargg lpitqlfril npnkaplrlk
      781 lrltydhfhq svqeifevnn lpveswq
//
LOCUS       XP_047287809             807 aa            linear   PRI 05-AUG-2025
DEFINITION  AP-1 complex subunit gamma-like 2 isoform X5 [Homo sapiens].
ACCESSION   XP_047287809
VERSION     XP_047287809.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431853.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 11% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..807
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..807
                     /product="AP-1 complex subunit gamma-like 2 isoform X5"
                     /calculated_mol_wt=89308
     Region          24..600
                     /region_name="Adaptin_N"
                     /note="Adaptin N terminal region; pfam01602"
                     /db_xref="CDD:396262"
     Region          694..802
                     /region_name="Alpha_adaptinC2"
                     /note="Adaptin C-terminal domain; smart00809"
                     /db_xref="CDD:197886"
     CDS             1..807
                     /gene="AP1G2"
                     /gene_synonym="G2AD"
                     /coded_by="XM_047431853.1:347..2770"
                     /db_xref="GeneID:8906"
                     /db_xref="HGNC:HGNC:556"
                     /db_xref="MIM:603534"
ORIGIN      
        1 mvvpslklqd lieeirgakt qaqereviqk ecahirasfr dgdpvhrhrq lakllyvhml
       61 gypahfgqme clkliassrf tdkrvgylga mlllderhda hllitnsikn dlsqgiqpvq
      121 glalctlstm gsaemcrdla peveklllqp spyvrkkail tavhmirkvp elssvflppc
      181 aqllherhhg kavgppilcf rsmdrrienr mgtpahrrrv vhthrhtrnr lscpwpppft
      241 sptltpgill gtitlitelc erspaalrhf rkvvpqlvhi lrtlvtmgys tehsisgvsd
      301 pflqvqilrl lrilgrnhee ssetmndlla qvatntdtsr nagnavlfet vltimdirsa
      361 aglrvlavni lgrfllnsdr niryvaltsl lrlvqsdhsa vqrhrptvve clretdasls
      421 rralelslal vnssnvramm qelqaflesc ppdlradcas gillaaerfa ptkrwhidti
      481 lhvlttagth vrddavanlt qliggaqelh aysvrrlyna laedisqqpl vqvaawcige
      541 ygdlllagnc eeieplqvde eevlallekv lqshmslpat rgyaltalmk lstrlcgdnk
      601 aailekmplv erdgpqadee akeskeaaql seaapvptep qasqlldlld lldgasgdvq
      661 hpphldpspg galvhlldlp cvppppapip dlkvferegv qlnlsfirpp enpallliti
      721 tatnfsegdv thficqaavp kslqlqlqap sgntvpargg lpitqlfril npnkaplrlk
      781 lrltydhfhq svqeifevnn lpveswq
//
LOCUS       XP_047287810             785 aa            linear   PRI 05-AUG-2025
DEFINITION  AP-1 complex subunit gamma-like 2 isoform X6 [Homo sapiens].
ACCESSION   XP_047287810
VERSION     XP_047287810.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431854.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..785
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..785
                     /product="AP-1 complex subunit gamma-like 2 isoform X6"
                     /calculated_mol_wt=86986
     Region          24..575
                     /region_name="Adaptin_N"
                     /note="Adaptin N terminal region; pfam01602"
                     /db_xref="CDD:396262"
     Region          672..780
                     /region_name="Alpha_adaptinC2"
                     /note="Adaptin C-terminal domain; smart00809"
                     /db_xref="CDD:197886"
     CDS             1..785
                     /gene="AP1G2"
                     /gene_synonym="G2AD"
                     /coded_by="XM_047431854.1:478..2835"
                     /db_xref="GeneID:8906"
                     /db_xref="HGNC:HGNC:556"
                     /db_xref="MIM:603534"
ORIGIN      
        1 mvvpslklqd lieeirgakt qaqereviqk ecahirasfr dgdpvhrhrq lakllyvhml
       61 gypahfgqme clkliassrf tdkrvgylga mlllderhda hllitnsikn dlsqgiqpvq
      121 glalctlstm gsaemcrdla peveklllqp spyvrkkail tavhmirkvp elssvflppc
      181 aqllherhhg illgtitlit elcerspaal rhfrkvvpql vhilrtlvtm gystehsisg
      241 vsdpflqvqi lrllrilgrn heessetmnd llaqvatntd tsrnagnavl fetvltimdi
      301 rsaaglrvla vnilgrflln sdrniryval tsllrlvqsd hsavqrhrpt vveclretda
      361 slsrralels lalvnssnvr ammqelqafl escppdlrad casgillaae rfaptkrwhi
      421 dtilhvltta gthvrddava nltqliggaq elhaysvrrl ynalaedisq qplvqvaawc
      481 igeygdllla gnceeieplq vdeeevlall ekvlqshmsl patrgyalta lmklstrlcg
      541 dnnrirqvvs iygscldvel qqraveydtl frkydhmraa ilekmplver dgpqadeeak
      601 eskeaaqlse aapvptepqa sqlldlldll dgasgdvqhp phldpspgga lvhlldlpcv
      661 ppppapipdl kvferegvql nlsfirppen palllitita tnfsegdvth ficqaavpks
      721 lqlqlqapsg ntvpargglp itqlfrilnp nkaplrlklr ltydhfhqsv qeifevnnlp
      781 veswq
//
LOCUS       XP_047287811             785 aa            linear   PRI 05-AUG-2025
DEFINITION  AP-1 complex subunit gamma-like 2 isoform X6 [Homo sapiens].
ACCESSION   XP_047287811
VERSION     XP_047287811.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431855.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..785
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..785
                     /product="AP-1 complex subunit gamma-like 2 isoform X6"
                     /calculated_mol_wt=86986
     Region          24..575
                     /region_name="Adaptin_N"
                     /note="Adaptin N terminal region; pfam01602"
                     /db_xref="CDD:396262"
     Region          672..780
                     /region_name="Alpha_adaptinC2"
                     /note="Adaptin C-terminal domain; smart00809"
                     /db_xref="CDD:197886"
     CDS             1..785
                     /gene="AP1G2"
                     /gene_synonym="G2AD"
                     /coded_by="XM_047431855.1:201..2558"
                     /db_xref="GeneID:8906"
                     /db_xref="HGNC:HGNC:556"
                     /db_xref="MIM:603534"
ORIGIN      
        1 mvvpslklqd lieeirgakt qaqereviqk ecahirasfr dgdpvhrhrq lakllyvhml
       61 gypahfgqme clkliassrf tdkrvgylga mlllderhda hllitnsikn dlsqgiqpvq
      121 glalctlstm gsaemcrdla peveklllqp spyvrkkail tavhmirkvp elssvflppc
      181 aqllherhhg illgtitlit elcerspaal rhfrkvvpql vhilrtlvtm gystehsisg
      241 vsdpflqvqi lrllrilgrn heessetmnd llaqvatntd tsrnagnavl fetvltimdi
      301 rsaaglrvla vnilgrflln sdrniryval tsllrlvqsd hsavqrhrpt vveclretda
      361 slsrralels lalvnssnvr ammqelqafl escppdlrad casgillaae rfaptkrwhi
      421 dtilhvltta gthvrddava nltqliggaq elhaysvrrl ynalaedisq qplvqvaawc
      481 igeygdllla gnceeieplq vdeeevlall ekvlqshmsl patrgyalta lmklstrlcg
      541 dnnrirqvvs iygscldvel qqraveydtl frkydhmraa ilekmplver dgpqadeeak
      601 eskeaaqlse aapvptepqa sqlldlldll dgasgdvqhp phldpspgga lvhlldlpcv
      661 ppppapipdl kvferegvql nlsfirppen palllitita tnfsegdvth ficqaavpks
      721 lqlqlqapsg ntvpargglp itqlfrilnp nkaplrlklr ltydhfhqsv qeifevnnlp
      781 veswq
//
LOCUS       XP_005268230             785 aa            linear   PRI 05-AUG-2025
DEFINITION  AP-1 complex subunit gamma-like 2 isoform X6 [Homo sapiens].
ACCESSION   XP_005268230
VERSION     XP_005268230.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005268173.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..785
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..785
                     /product="AP-1 complex subunit gamma-like 2 isoform X6"
                     /calculated_mol_wt=86986
     Region          24..575
                     /region_name="Adaptin_N"
                     /note="Adaptin N terminal region; pfam01602"
                     /db_xref="CDD:396262"
     Region          672..780
                     /region_name="Alpha_adaptinC2"
                     /note="Adaptin C-terminal domain; smart00809"
                     /db_xref="CDD:197886"
     CDS             1..785
                     /gene="AP1G2"
                     /gene_synonym="G2AD"
                     /coded_by="XM_005268173.4:55..2412"
                     /db_xref="GeneID:8906"
                     /db_xref="HGNC:HGNC:556"
                     /db_xref="MIM:603534"
ORIGIN      
        1 mvvpslklqd lieeirgakt qaqereviqk ecahirasfr dgdpvhrhrq lakllyvhml
       61 gypahfgqme clkliassrf tdkrvgylga mlllderhda hllitnsikn dlsqgiqpvq
      121 glalctlstm gsaemcrdla peveklllqp spyvrkkail tavhmirkvp elssvflppc
      181 aqllherhhg illgtitlit elcerspaal rhfrkvvpql vhilrtlvtm gystehsisg
      241 vsdpflqvqi lrllrilgrn heessetmnd llaqvatntd tsrnagnavl fetvltimdi
      301 rsaaglrvla vnilgrflln sdrniryval tsllrlvqsd hsavqrhrpt vveclretda
      361 slsrralels lalvnssnvr ammqelqafl escppdlrad casgillaae rfaptkrwhi
      421 dtilhvltta gthvrddava nltqliggaq elhaysvrrl ynalaedisq qplvqvaawc
      481 igeygdllla gnceeieplq vdeeevlall ekvlqshmsl patrgyalta lmklstrlcg
      541 dnnrirqvvs iygscldvel qqraveydtl frkydhmraa ilekmplver dgpqadeeak
      601 eskeaaqlse aapvptepqa sqlldlldll dgasgdvqhp phldpspgga lvhlldlpcv
      661 ppppapipdl kvferegvql nlsfirppen palllitita tnfsegdvth ficqaavpks
      721 lqlqlqapsg ntvpargglp itqlfrilnp nkaplrlklr ltydhfhqsv qeifevnnlp
      781 veswq
//
LOCUS       XP_005268229             785 aa            linear   PRI 05-AUG-2025
DEFINITION  AP-1 complex subunit gamma-like 2 isoform X6 [Homo sapiens].
ACCESSION   XP_005268229
VERSION     XP_005268229.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005268172.4
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 11% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..785
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..785
                     /product="AP-1 complex subunit gamma-like 2 isoform X6"
                     /calculated_mol_wt=86986
     Region          24..575
                     /region_name="Adaptin_N"
                     /note="Adaptin N terminal region; pfam01602"
                     /db_xref="CDD:396262"
     Region          672..780
                     /region_name="Alpha_adaptinC2"
                     /note="Adaptin C-terminal domain; smart00809"
                     /db_xref="CDD:197886"
     CDS             1..785
                     /gene="AP1G2"
                     /gene_synonym="G2AD"
                     /coded_by="XM_005268172.4:347..2704"
                     /db_xref="GeneID:8906"
                     /db_xref="HGNC:HGNC:556"
                     /db_xref="MIM:603534"
ORIGIN      
        1 mvvpslklqd lieeirgakt qaqereviqk ecahirasfr dgdpvhrhrq lakllyvhml
       61 gypahfgqme clkliassrf tdkrvgylga mlllderhda hllitnsikn dlsqgiqpvq
      121 glalctlstm gsaemcrdla peveklllqp spyvrkkail tavhmirkvp elssvflppc
      181 aqllherhhg illgtitlit elcerspaal rhfrkvvpql vhilrtlvtm gystehsisg
      241 vsdpflqvqi lrllrilgrn heessetmnd llaqvatntd tsrnagnavl fetvltimdi
      301 rsaaglrvla vnilgrflln sdrniryval tsllrlvqsd hsavqrhrpt vveclretda
      361 slsrralels lalvnssnvr ammqelqafl escppdlrad casgillaae rfaptkrwhi
      421 dtilhvltta gthvrddava nltqliggaq elhaysvrrl ynalaedisq qplvqvaawc
      481 igeygdllla gnceeieplq vdeeevlall ekvlqshmsl patrgyalta lmklstrlcg
      541 dnnrirqvvs iygscldvel qqraveydtl frkydhmraa ilekmplver dgpqadeeak
      601 eskeaaqlse aapvptepqa sqlldlldll dgasgdvqhp phldpspgga lvhlldlpcv
      661 ppppapipdl kvferegvql nlsfirppen palllitita tnfsegdvth ficqaavpks
      721 lqlqlqapsg ntvpargglp itqlfrilnp nkaplrlklr ltydhfhqsv qeifevnnlp
      781 veswq
//
LOCUS       XP_047287812             784 aa            linear   PRI 05-AUG-2025
DEFINITION  AP-1 complex subunit gamma-like 2 isoform X7 [Homo sapiens].
ACCESSION   XP_047287812
VERSION     XP_047287812.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431856.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 8% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..784
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..784
                     /product="AP-1 complex subunit gamma-like 2 isoform X7"
                     /calculated_mol_wt=86333
     Region          58..577
                     /region_name="Adaptin_N"
                     /note="Adaptin N terminal region; pfam01602"
                     /db_xref="CDD:396262"
     Region          671..779
                     /region_name="Alpha_adaptinC2"
                     /note="Adaptin C-terminal domain; smart00809"
                     /db_xref="CDD:197886"
     CDS             1..784
                     /gene="AP1G2"
                     /gene_synonym="G2AD"
                     /coded_by="XM_047431856.1:241..2595"
                     /db_xref="GeneID:8906"
                     /db_xref="HGNC:HGNC:556"
                     /db_xref="MIM:603534"
ORIGIN      
        1 mlnrkgrrwg adacvvgfsg ggvgaefgdp lrermvvpsl klqdlieeir gaktqaqere
       61 viqkecahir asfrdgdpvh rhrqlaklly vhmlgypahf gqmeclklia ssrftdkrvg
      121 ylgamlllde rhdahllitn sikndlsqgi qpvqglalct lstmgsaemc rdlapevekl
      181 llqpspyvrk kailtavhmi rkvpelssvf lppcaqllhe rhhgillgti tlitelcers
      241 paalrhfrkv vpqlvhilrt lvtmgysteh sisgvsdpfl qvqilrllri lgrnheesse
      301 tmndllaqva tntdtsrnag navlfetvlt imdirsaagl rvlavnilgr fllnsdrnir
      361 yvaltsllrl vqsdhsavqr hrptvveclr etdaslsrra lelslalvns snvrammqel
      421 qaflescppd lradcasgil laaerfaptk rwhidtilhv lttagthvrd davanltqli
      481 ggaqelhays vrrlynalae disqqplvqv aawcigeygd lllagnceei eplqvdeeev
      541 lallekvlqs hmslpatrgy altalmklst rlcgdnkaai lekmplverd gpqadeeake
      601 skeaaqlsea apvptepqas qlldlldlld gasgdvqhpp hldpspggal vhlldlpcvp
      661 pppapipdlk vferegvqln lsfirppenp alllititat nfsegdvthf icqaavpksl
      721 qlqlqapsgn tvpargglpi tqlfrilnpn kaplrlklrl tydhfhqsvq eifevnnlpv
      781 eswq
//
LOCUS       XP_047287813             750 aa            linear   PRI 05-AUG-2025
DEFINITION  AP-1 complex subunit gamma-like 2 isoform X8 [Homo sapiens].
ACCESSION   XP_047287813
VERSION     XP_047287813.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431857.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..750
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..750
                     /product="AP-1 complex subunit gamma-like 2 isoform X8"
                     /calculated_mol_wt=82729
     Region          24..543
                     /region_name="Adaptin_N"
                     /note="Adaptin N terminal region; pfam01602"
                     /db_xref="CDD:396262"
     Region          637..745
                     /region_name="Alpha_adaptinC2"
                     /note="Adaptin C-terminal domain; smart00809"
                     /db_xref="CDD:197886"
     CDS             1..750
                     /gene="AP1G2"
                     /gene_synonym="G2AD"
                     /coded_by="XM_047431857.1:59..2311"
                     /db_xref="GeneID:8906"
                     /db_xref="HGNC:HGNC:556"
                     /db_xref="MIM:603534"
ORIGIN      
        1 mvvpslklqd lieeirgakt qaqereviqk ecahirasfr dgdpvhrhrq lakllyvhml
       61 gypahfgqme clkliassrf tdkrvgylga mlllderhda hllitnsikn dlsqgiqpvq
      121 glalctlstm gsaemcrdla peveklllqp spyvrkkail tavhmirkvp elssvflppc
      181 aqllherhhg illgtitlit elcerspaal rhfrkvvpql vhilrtlvtm gystehsisg
      241 vsdpflqvqi lrllrilgrn heessetmnd llaqvatntd tsrnagnavl fetvltimdi
      301 rsaaglrvla vnilgrflln sdrniryval tsllrlvqsd hsavqrhrpt vveclretda
      361 slsrralels lalvnssnvr ammqelqafl escppdlrad casgillaae rfaptkrwhi
      421 dtilhvltta gthvrddava nltqliggaq elhaysvrrl ynalaedisq qplvqvaawc
      481 igeygdllla gnceeieplq vdeeevlall ekvlqshmsl patrgyalta lmklstrlcg
      541 dnkaailekm plverdgpqa deeakeskea aqlseaapvp tepqasqlld lldlldgasg
      601 dvqhpphldp spggalvhll dlpcvppppa pipdlkvfer egvqlnlsfi rppenpalll
      661 ititatnfse gdvthficqa avpkslqlql qapsgntvpa rgglpitqlf rilnpnkapl
      721 rlklrltydh fhqsvqeife vnnlpveswq
//
LOCUS       XP_047287814             750 aa            linear   PRI 05-AUG-2025
DEFINITION  AP-1 complex subunit gamma-like 2 isoform X8 [Homo sapiens].
ACCESSION   XP_047287814
VERSION     XP_047287814.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431858.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..750
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..750
                     /product="AP-1 complex subunit gamma-like 2 isoform X8"
                     /calculated_mol_wt=82729
     Region          24..543
                     /region_name="Adaptin_N"
                     /note="Adaptin N terminal region; pfam01602"
                     /db_xref="CDD:396262"
     Region          637..745
                     /region_name="Alpha_adaptinC2"
                     /note="Adaptin C-terminal domain; smart00809"
                     /db_xref="CDD:197886"
     CDS             1..750
                     /gene="AP1G2"
                     /gene_synonym="G2AD"
                     /coded_by="XM_047431858.1:201..2453"
                     /db_xref="GeneID:8906"
                     /db_xref="HGNC:HGNC:556"
                     /db_xref="MIM:603534"
ORIGIN      
        1 mvvpslklqd lieeirgakt qaqereviqk ecahirasfr dgdpvhrhrq lakllyvhml
       61 gypahfgqme clkliassrf tdkrvgylga mlllderhda hllitnsikn dlsqgiqpvq
      121 glalctlstm gsaemcrdla peveklllqp spyvrkkail tavhmirkvp elssvflppc
      181 aqllherhhg illgtitlit elcerspaal rhfrkvvpql vhilrtlvtm gystehsisg
      241 vsdpflqvqi lrllrilgrn heessetmnd llaqvatntd tsrnagnavl fetvltimdi
      301 rsaaglrvla vnilgrflln sdrniryval tsllrlvqsd hsavqrhrpt vveclretda
      361 slsrralels lalvnssnvr ammqelqafl escppdlrad casgillaae rfaptkrwhi
      421 dtilhvltta gthvrddava nltqliggaq elhaysvrrl ynalaedisq qplvqvaawc
      481 igeygdllla gnceeieplq vdeeevlall ekvlqshmsl patrgyalta lmklstrlcg
      541 dnkaailekm plverdgpqa deeakeskea aqlseaapvp tepqasqlld lldlldgasg
      601 dvqhpphldp spggalvhll dlpcvppppa pipdlkvfer egvqlnlsfi rppenpalll
      661 ititatnfse gdvthficqa avpkslqlql qapsgntvpa rgglpitqlf rilnpnkapl
      721 rlklrltydh fhqsvqeife vnnlpveswq
//
LOCUS       XP_047287815             750 aa            linear   PRI 05-AUG-2025
DEFINITION  AP-1 complex subunit gamma-like 2 isoform X8 [Homo sapiens].
ACCESSION   XP_047287815
VERSION     XP_047287815.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431859.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..750
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..750
                     /product="AP-1 complex subunit gamma-like 2 isoform X8"
                     /calculated_mol_wt=82729
     Region          24..543
                     /region_name="Adaptin_N"
                     /note="Adaptin N terminal region; pfam01602"
                     /db_xref="CDD:396262"
     Region          637..745
                     /region_name="Alpha_adaptinC2"
                     /note="Adaptin C-terminal domain; smart00809"
                     /db_xref="CDD:197886"
     CDS             1..750
                     /gene="AP1G2"
                     /gene_synonym="G2AD"
                     /coded_by="XM_047431859.1:55..2307"
                     /db_xref="GeneID:8906"
                     /db_xref="HGNC:HGNC:556"
                     /db_xref="MIM:603534"
ORIGIN      
        1 mvvpslklqd lieeirgakt qaqereviqk ecahirasfr dgdpvhrhrq lakllyvhml
       61 gypahfgqme clkliassrf tdkrvgylga mlllderhda hllitnsikn dlsqgiqpvq
      121 glalctlstm gsaemcrdla peveklllqp spyvrkkail tavhmirkvp elssvflppc
      181 aqllherhhg illgtitlit elcerspaal rhfrkvvpql vhilrtlvtm gystehsisg
      241 vsdpflqvqi lrllrilgrn heessetmnd llaqvatntd tsrnagnavl fetvltimdi
      301 rsaaglrvla vnilgrflln sdrniryval tsllrlvqsd hsavqrhrpt vveclretda
      361 slsrralels lalvnssnvr ammqelqafl escppdlrad casgillaae rfaptkrwhi
      421 dtilhvltta gthvrddava nltqliggaq elhaysvrrl ynalaedisq qplvqvaawc
      481 igeygdllla gnceeieplq vdeeevlall ekvlqshmsl patrgyalta lmklstrlcg
      541 dnkaailekm plverdgpqa deeakeskea aqlseaapvp tepqasqlld lldlldgasg
      601 dvqhpphldp spggalvhll dlpcvppppa pipdlkvfer egvqlnlsfi rppenpalll
      661 ititatnfse gdvthficqa avpkslqlql qapsgntvpa rgglpitqlf rilnpnkapl
      721 rlklrltydh fhqsvqeife vnnlpveswq
//
LOCUS       XP_047287816             663 aa            linear   PRI 05-AUG-2025
DEFINITION  AP-1 complex subunit gamma-like 2 isoform X9 [Homo sapiens].
ACCESSION   XP_047287816
VERSION     XP_047287816.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431860.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 9% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..663
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..663
                     /product="AP-1 complex subunit gamma-like 2 isoform X9"
                     /calculated_mol_wt=73517
     Region          58..634
                     /region_name="Adaptin_N"
                     /note="Adaptin N terminal region; pfam01602"
                     /db_xref="CDD:396262"
     CDS             1..663
                     /gene="AP1G2"
                     /gene_synonym="G2AD"
                     /coded_by="XM_047431860.1:241..2232"
                     /db_xref="GeneID:8906"
                     /db_xref="HGNC:HGNC:556"
                     /db_xref="MIM:603534"
ORIGIN      
        1 mlnrkgrrwg adacvvgfsg ggvgaefgdp lrermvvpsl klqdlieeir gaktqaqere
       61 viqkecahir asfrdgdpvh rhrqlaklly vhmlgypahf gqmeclklia ssrftdkrvg
      121 ylgamlllde rhdahllitn sikndlsqgi qpvqglalct lstmgsaemc rdlapevekl
      181 llqpspyvrk kailtavhmi rkvpelssvf lppcaqllhe rhhgkavgpp ilcfrsmdrr
      241 ienrmgtpah rrrvvhthrh trnrlscpwp ppftsptltp gillgtitli telcerspaa
      301 lrhfrkvvpq lvhilrtlvt mgystehsis gvsdpflqvq ilrllrilgr nheessetmn
      361 dllaqvatnt dtsrnagnav lfetvltimd irsaaglrvl avnilgrfll nsdrniryva
      421 ltsllrlvqs dhsavqrhrp tvveclretd aslsrralel slalvnssnv rammqelqaf
      481 lescppdlra dcasgillaa erfaptkrwh idtilhvltt agthvrddav anltqligga
      541 qelhaysvrr lynalaedis qqplvqvaaw cigeygdlll agnceeiepl qvdeeevlal
      601 lekvlqshms lpatrgyalt almklstrlc gdnkwcpstg aawtwscssg lwsmthssgn
      661 ttt
//
LOCUS       XP_047287817             638 aa            linear   PRI 05-AUG-2025
DEFINITION  AP-1 complex subunit gamma-like 2 isoform X10 [Homo sapiens].
ACCESSION   XP_047287817
VERSION     XP_047287817.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431861.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 10% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..638
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..638
                     /product="AP-1 complex subunit gamma-like 2 isoform X10"
                     /calculated_mol_wt=70798
     Region          58..637
                     /region_name="Adaptin_N"
                     /note="Adaptin N terminal region; pfam01602"
                     /db_xref="CDD:396262"
     CDS             1..638
                     /gene="AP1G2"
                     /gene_synonym="G2AD"
                     /coded_by="XM_047431861.1:241..2157"
                     /db_xref="GeneID:8906"
                     /db_xref="HGNC:HGNC:556"
                     /db_xref="MIM:603534"
ORIGIN      
        1 mlnrkgrrwg adacvvgfsg ggvgaefgdp lrermvvpsl klqdlieeir gaktqaqere
       61 viqkecahir asfrdgdpvh rhrqlaklly vhmlgypahf gqmeclklia ssrftdkrvg
      121 ylgamlllde rhdahllitn sikndlsqgi qpvqglalct lstmgsaemc rdlapevekl
      181 llqpspyvrk kailtavhmi rkvpelssvf lppcaqllhe rhhgkavgpp ilcfrsmdrr
      241 ienrmgtpah rrrvvhthrh trnrlscpwp ppftsptltp gillgtitli telcerspaa
      301 lrhfrkvvpq lvhilrtlvt mgystehsis gvsdpflqvq ilrllrilgr nheessetmn
      361 dllaqvatnt dtsrnagnav lfetvltimd irsaaglrvl avnilgrfll nsdrniryva
      421 ltsllrlvqs dhsavqrhrp tvveclretd aslsrralel slalvnssnv rammqelqaf
      481 lescppdlra dcasgillaa erfaptkrwh idtilhvltt agthvrddav anltqligga
      541 qelhaysvrr lynalaedis qqplvqvaaw cigeygdlll agnceeiepl qvdeeevlal
      601 lekvlqshms lpatrgyalt almklstrlc gdnngtlp
//
LOCUS       XP_047287818             586 aa            linear   PRI 05-AUG-2025
DEFINITION  AP-1 complex subunit gamma-like 2 isoform X11 [Homo sapiens].
ACCESSION   XP_047287818
VERSION     XP_047287818.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431862.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 11% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..586
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..586
                     /product="AP-1 complex subunit gamma-like 2 isoform X11"
                     /calculated_mol_wt=65194
     Region          58..566
                     /region_name="Adaptin_N"
                     /note="Adaptin N terminal region; pfam01602"
                     /db_xref="CDD:396262"
     CDS             1..586
                     /gene="AP1G2"
                     /gene_synonym="G2AD"
                     /coded_by="XM_047431862.1:241..2001"
                     /db_xref="GeneID:8906"
                     /db_xref="HGNC:HGNC:556"
                     /db_xref="MIM:603534"
ORIGIN      
        1 mlnrkgrrwg adacvvgfsg ggvgaefgdp lrermvvpsl klqdlieeir gaktqaqere
       61 viqkecahir asfrdgdpvh rhrqlaklly vhmlgypahf gqmeclklia ssrftdkrvg
      121 ylgamlllde rhdahllitn sikndlsqgi qpvqglalct lstmgsaemc rdlapevekl
      181 llqpspyvrk kailtavhmi rkvpelssvf lppcaqllhe rhhgkavgpp ilcfrsmdrr
      241 ienrmgtpah rrrvvhthrh trnrlscpwp ppftsptltp gillgtitli telcerspaa
      301 lrhfrkvvpq lvhilrtlvt mgystehsis gvsdpflqvq ilrllrilgr nheessetmn
      361 dllaqvatnt dtsrnagnav lfetvltimd irsaaglrvl avnilgrfll nsdrniryva
      421 ltsllrlvqs dhsavqrhrp tvveclretd aslsrralel slalvnssnv rammqelqaf
      481 lescppdlra dcasgillaa erfaptkrwh idtilhvltt agthvrddav anltqligga
      541 qelhaysvrr lynalaedis qvtaaytvqk tsehralflr tsglls
//
LOCUS       XP_047287819             575 aa            linear   PRI 05-AUG-2025
DEFINITION  AP-1 complex subunit gamma-like 2 isoform X12 [Homo sapiens].
ACCESSION   XP_047287819
VERSION     XP_047287819.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431863.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..575
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..575
                     /product="AP-1 complex subunit gamma-like 2 isoform X12"
                     /calculated_mol_wt=63307
     Region          <7..365
                     /region_name="Adaptin_N"
                     /note="Adaptin N terminal region; pfam01602"
                     /db_xref="CDD:396262"
     Region          462..570
                     /region_name="Alpha_adaptinC2"
                     /note="Adaptin C-terminal domain; smart00809"
                     /db_xref="CDD:197886"
     CDS             1..575
                     /gene="AP1G2"
                     /gene_synonym="G2AD"
                     /coded_by="XM_047431863.1:79..1806"
                     /db_xref="GeneID:8906"
                     /db_xref="HGNC:HGNC:556"
                     /db_xref="MIM:603534"
ORIGIN      
        1 msvtmvvpql vhilrtlvtm gystehsisg vsdpflqvqi lrllrilgrn heessetmnd
       61 llaqvatntd tsrnagnavl fetvltimdi rsaaglrvla vnilgrflln sdrniryval
      121 tsllrlvqsd hsavqrhrpt vveclretda slsrralels lalvnssnvr ammqelqafl
      181 escppdlrad casgillaae rfaptkrwhi dtilhvltta gthvrddava nltqliggaq
      241 elhaysvrrl ynalaedisq qplvqvaawc igeygdllla gnceeieplq vdeeevlall
      301 ekvlqshmsl patrgyalta lmklstrlcg dnnrirqvvs iygscldvel qqraveydtl
      361 frkydhmraa ilekmplver dgpqadeeak eskeaaqlse aapvptepqa sqlldlldll
      421 dgasgdvqhp phldpspgga lvhlldlpcv ppppapipdl kvferegvql nlsfirppen
      481 palllitita tnfsegdvth ficqaavpks lqlqlqapsg ntvpargglp itqlfrilnp
      541 nkaplrlklr ltydhfhqsv qeifevnnlp veswq
//
LOCUS       XP_047287820             552 aa            linear   PRI 05-AUG-2025
DEFINITION  AP-1 complex subunit gamma-like 2 isoform X13 [Homo sapiens].
ACCESSION   XP_047287820
VERSION     XP_047287820.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431864.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..552
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..552
                     /product="AP-1 complex subunit gamma-like 2 isoform X13"
                     /calculated_mol_wt=61590
     Region          24..532
                     /region_name="Adaptin_N"
                     /note="Adaptin N terminal region; pfam01602"
                     /db_xref="CDD:396262"
     CDS             1..552
                     /gene="AP1G2"
                     /gene_synonym="G2AD"
                     /coded_by="XM_047431864.1:59..1717"
                     /db_xref="GeneID:8906"
                     /db_xref="HGNC:HGNC:556"
                     /db_xref="MIM:603534"
ORIGIN      
        1 mvvpslklqd lieeirgakt qaqereviqk ecahirasfr dgdpvhrhrq lakllyvhml
       61 gypahfgqme clkliassrf tdkrvgylga mlllderhda hllitnsikn dlsqgiqpvq
      121 glalctlstm gsaemcrdla peveklllqp spyvrkkail tavhmirkvp elssvflppc
      181 aqllherhhg kavgppilcf rsmdrrienr mgtpahrrrv vhthrhtrnr lscpwpppft
      241 sptltpgill gtitlitelc erspaalrhf rkvvpqlvhi lrtlvtmgys tehsisgvsd
      301 pflqvqilrl lrilgrnhee ssetmndlla qvatntdtsr nagnavlfet vltimdirsa
      361 aglrvlavni lgrfllnsdr niryvaltsl lrlvqsdhsa vqrhrptvve clretdasls
      421 rralelslal vnssnvramm qelqaflesc ppdlradcas gillaaerfa ptkrwhidti
      481 lhvlttagth vrddavanlt qliggaqelh aysvrrlyna laedisqvta aytvqktseh
      541 ralflrtsgl ls
//
LOCUS       XP_047287821             529 aa            linear   PRI 05-AUG-2025
DEFINITION  AP-1 complex subunit gamma-like 2 isoform X14 [Homo sapiens].
ACCESSION   XP_047287821
VERSION     XP_047287821.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431865.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 12% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..529
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..529
                     /product="AP-1 complex subunit gamma-like 2 isoform X14"
                     /calculated_mol_wt=58615
     Region          58..509
                     /region_name="Adaptin_N"
                     /note="Adaptin N terminal region; pfam01602"
                     /db_xref="CDD:396262"
     CDS             1..529
                     /gene="AP1G2"
                     /gene_synonym="G2AD"
                     /coded_by="XM_047431865.1:241..1830"
                     /db_xref="GeneID:8906"
                     /db_xref="HGNC:HGNC:556"
                     /db_xref="MIM:603534"
ORIGIN      
        1 mlnrkgrrwg adacvvgfsg ggvgaefgdp lrermvvpsl klqdlieeir gaktqaqere
       61 viqkecahir asfrdgdpvh rhrqlaklly vhmlgypahf gqmeclklia ssrftdkrvg
      121 ylgamlllde rhdahllitn sikndlsqgi qpvqglalct lstmgsaemc rdlapevekl
      181 llqpspyvrk kailtavhmi rkvpelssvf lppcaqllhe rhhgillgti tlitelcers
      241 paalrhfrkv vpqlvhilrt lvtmgysteh sisgvsdpfl qvqilrllri lgrnheesse
      301 tmndllaqva tntdtsrnag navlfetvlt imdirsaagl rvlavnilgr fllnsdrnir
      361 yvaltsllrl vqsdhsavqr hrptvveclr etdaslsrra lelslalvns snvrammqel
      421 qaflescppd lradcasgil laaerfaptk rwhidtilhv lttagthvrd davanltqli
      481 ggaqelhays vrrlynalae disqvtaayt vqktsehral flrtsglls
//
LOCUS       XP_047287822             582 aa            linear   PRI 05-AUG-2025
DEFINITION  AP-1 complex subunit gamma-like 2 isoform X15 [Homo sapiens].
ACCESSION   XP_047287822
VERSION     XP_047287822.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431866.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..582
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..582
                     /product="AP-1 complex subunit gamma-like 2 isoform X15"
                     /calculated_mol_wt=64255
     Region          64..553
                     /region_name="Adaptin_N"
                     /note="Adaptin N terminal region; pfam01602"
                     /db_xref="CDD:396262"
     CDS             1..582
                     /gene="AP1G2"
                     /gene_synonym="G2AD"
                     /coded_by="XM_047431866.1:766..2514"
                     /db_xref="GeneID:8906"
                     /db_xref="HGNC:HGNC:556"
                     /db_xref="MIM:603534"
ORIGIN      
        1 mrgtmptcsl ptasrservl aitwnqgdgr vgtleipgdc llwvlkrtdf lrgltdrppk
       61 pcsdlsqgiq pvqglalctl stmgsaemcr dlapevekll lqpspyvrkk ailtavhmir
      121 kvpelssvfl ppcaqllher hhgkavgppi lcfrsmdrri enrmgtpahr rrvvhthrht
      181 rnrlscpwpp pftsptltpg illgtitlit elcerspaal rhfrkvvpql vhilrtlvtm
      241 gystehsisg vsdpflqvqi lrllrilgrn heessetmnd llaqvatntd tsrnagnavl
      301 fetvltimdi rsaaglrvla vnilgrflln sdrniryval tsllrlvqsd hsavqrhrpt
      361 vveclretda slsrralels lalvnssnvr ammqelqafl escppdlrad casgillaae
      421 rfaptkrwhi dtilhvltta gthvrddava nltqliggaq elhaysvrrl ynalaedisq
      481 qplvqvaawc igeygdllla gnceeieplq vdeeevlall ekvlqshmsl patrgyalta
      541 lmklstrlcg dnkwcpstga awtwscssgl wsmthssgnt tt
//
LOCUS       XP_047287823             495 aa            linear   PRI 05-AUG-2025
DEFINITION  AP-1 complex subunit gamma-like 2 isoform X16 [Homo sapiens].
ACCESSION   XP_047287823
VERSION     XP_047287823.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431867.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..495
                     /product="AP-1 complex subunit gamma-like 2 isoform X16"
                     /calculated_mol_wt=55011
     Region          24..475
                     /region_name="Adaptin_N"
                     /note="Adaptin N terminal region; pfam01602"
                     /db_xref="CDD:396262"
     CDS             1..495
                     /gene="AP1G2"
                     /gene_synonym="G2AD"
                     /coded_by="XM_047431867.1:59..1546"
                     /db_xref="GeneID:8906"
                     /db_xref="HGNC:HGNC:556"
                     /db_xref="MIM:603534"
ORIGIN      
        1 mvvpslklqd lieeirgakt qaqereviqk ecahirasfr dgdpvhrhrq lakllyvhml
       61 gypahfgqme clkliassrf tdkrvgylga mlllderhda hllitnsikn dlsqgiqpvq
      121 glalctlstm gsaemcrdla peveklllqp spyvrkkail tavhmirkvp elssvflppc
      181 aqllherhhg illgtitlit elcerspaal rhfrkvvpql vhilrtlvtm gystehsisg
      241 vsdpflqvqi lrllrilgrn heessetmnd llaqvatntd tsrnagnavl fetvltimdi
      301 rsaaglrvla vnilgrflln sdrniryval tsllrlvqsd hsavqrhrpt vveclretda
      361 slsrralels lalvnssnvr ammqelqafl escppdlrad casgillaae rfaptkrwhi
      421 dtilhvltta gthvrddava nltqliggaq elhaysvrrl ynalaedisq vtaaytvqkt
      481 sehralflrt sglls
//
LOCUS       XP_047287824             495 aa            linear   PRI 05-AUG-2025
DEFINITION  AP-1 complex subunit gamma-like 2 isoform X16 [Homo sapiens].
ACCESSION   XP_047287824
VERSION     XP_047287824.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431868.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..495
                     /product="AP-1 complex subunit gamma-like 2 isoform X16"
                     /calculated_mol_wt=55011
     Region          24..475
                     /region_name="Adaptin_N"
                     /note="Adaptin N terminal region; pfam01602"
                     /db_xref="CDD:396262"
     CDS             1..495
                     /gene="AP1G2"
                     /gene_synonym="G2AD"
                     /coded_by="XM_047431868.1:55..1542"
                     /db_xref="GeneID:8906"
                     /db_xref="HGNC:HGNC:556"
                     /db_xref="MIM:603534"
ORIGIN      
        1 mvvpslklqd lieeirgakt qaqereviqk ecahirasfr dgdpvhrhrq lakllyvhml
       61 gypahfgqme clkliassrf tdkrvgylga mlllderhda hllitnsikn dlsqgiqpvq
      121 glalctlstm gsaemcrdla peveklllqp spyvrkkail tavhmirkvp elssvflppc
      181 aqllherhhg illgtitlit elcerspaal rhfrkvvpql vhilrtlvtm gystehsisg
      241 vsdpflqvqi lrllrilgrn heessetmnd llaqvatntd tsrnagnavl fetvltimdi
      301 rsaaglrvla vnilgrflln sdrniryval tsllrlvqsd hsavqrhrpt vveclretda
      361 slsrralels lalvnssnvr ammqelqafl escppdlrad casgillaae rfaptkrwhi
      421 dtilhvltta gthvrddava nltqliggaq elhaysvrrl ynalaedisq vtaaytvqkt
      481 sehralflrt sglls
//
LOCUS       XP_047287825             495 aa            linear   PRI 05-AUG-2025
DEFINITION  AP-1 complex subunit gamma-like 2 isoform X16 [Homo sapiens].
ACCESSION   XP_047287825
VERSION     XP_047287825.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431869.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 18% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..495
                     /product="AP-1 complex subunit gamma-like 2 isoform X16"
                     /calculated_mol_wt=55011
     Region          24..475
                     /region_name="Adaptin_N"
                     /note="Adaptin N terminal region; pfam01602"
                     /db_xref="CDD:396262"
     CDS             1..495
                     /gene="AP1G2"
                     /gene_synonym="G2AD"
                     /coded_by="XM_047431869.1:347..1834"
                     /db_xref="GeneID:8906"
                     /db_xref="HGNC:HGNC:556"
                     /db_xref="MIM:603534"
ORIGIN      
        1 mvvpslklqd lieeirgakt qaqereviqk ecahirasfr dgdpvhrhrq lakllyvhml
       61 gypahfgqme clkliassrf tdkrvgylga mlllderhda hllitnsikn dlsqgiqpvq
      121 glalctlstm gsaemcrdla peveklllqp spyvrkkail tavhmirkvp elssvflppc
      181 aqllherhhg illgtitlit elcerspaal rhfrkvvpql vhilrtlvtm gystehsisg
      241 vsdpflqvqi lrllrilgrn heessetmnd llaqvatntd tsrnagnavl fetvltimdi
      301 rsaaglrvla vnilgrflln sdrniryval tsllrlvqsd hsavqrhrpt vveclretda
      361 slsrralels lalvnssnvr ammqelqafl escppdlrad casgillaae rfaptkrwhi
      421 dtilhvltta gthvrddava nltqliggaq elhaysvrrl ynalaedisq vtaaytvqkt
      481 sehralflrt sglls
//
LOCUS       XP_047287826             435 aa            linear   PRI 05-AUG-2025
DEFINITION  AP-1 complex subunit gamma-like 2 isoform X17 [Homo sapiens].
ACCESSION   XP_047287826
VERSION     XP_047287826.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431870.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 15% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..435
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..435
                     /product="AP-1 complex subunit gamma-like 2 isoform X17"
                     /calculated_mol_wt=48280
     Region          58..>417
                     /region_name="Adaptin_N"
                     /note="Adaptin N terminal region; pfam01602"
                     /db_xref="CDD:396262"
     CDS             1..435
                     /gene="AP1G2"
                     /gene_synonym="G2AD"
                     /coded_by="XM_047431870.1:241..1548"
                     /db_xref="GeneID:8906"
                     /db_xref="HGNC:HGNC:556"
                     /db_xref="MIM:603534"
ORIGIN      
        1 mlnrkgrrwg adacvvgfsg ggvgaefgdp lrermvvpsl klqdlieeir gaktqaqere
       61 viqkecahir asfrdgdpvh rhrqlaklly vhmlgypahf gqmeclklia ssrftdkrvg
      121 ylgamlllde rhdahllitn sikndlsqgi qpvqglalct lstmgsaemc rdlapevekl
      181 llqpspyvrk kailtavhmi rkvpelssvf lppcaqllhe rhhgkavgpp ilcfrsmdrr
      241 ienrmgtpah rrrvvhthrh trnrlscpwp ppftsptltp gillgtitli telcerspaa
      301 lrhfrkvvpq lvhilrtlvt mgystehsis gvsdpflqvq ilrllrilgr nheessetmn
      361 dllaqvatnt dtsrnagnav lfetvltimd irsaaglrvl avnilgrfll nsdrnirtgr
      421 gvgadghgmi eppps
//
LOCUS       XP_047287827             271 aa            linear   PRI 05-AUG-2025
DEFINITION  mitochondrial 2-oxodicarboxylate carrier isoform X1 [Homo sapiens].
ACCESSION   XP_047287827
VERSION     XP_047287827.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431871.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..271
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..271
                     /product="mitochondrial 2-oxodicarboxylate carrier isoform
                     X1"
                     /calculated_mol_wt=29877
     Region          15..77
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     Region          77..169
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     Region          177..270
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     CDS             1..271
                     /gene="SLC25A21"
                     /gene_synonym="MTDPS18; ODC; ODC1"
                     /coded_by="XM_047431871.1:257..1072"
                     /db_xref="GeneID:89874"
                     /db_xref="HGNC:HGNC:14411"
                     /db_xref="MIM:607571"
ORIGIN      
        1 msakpevslv reasrqivag gsaglveicl mhpldvvktr lfgfykgilp pilaetpkra
       61 vkfftfeqyk kllgyvslsp altfaiaglg sglteaivvn pfevvkvglq anrntfaeqp
      121 stvgyarqii kkegwglqgl nkgltatlgr hgvfnmvyfg fyynvknmip vnkdpilefw
      181 rkfgigllsg tiasvinipf dvaksriqgp qpvpgeikyr tcfktmatvy qeegilalyk
      241 gllpkimrlg pggavmllvy eytyswlqen w
//
LOCUS       XP_011535590             269 aa            linear   PRI 05-AUG-2025
DEFINITION  mitochondrial 2-oxodicarboxylate carrier isoform X2 [Homo sapiens].
ACCESSION   XP_011535590
VERSION     XP_011535590.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537288.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..269
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..269
                     /product="mitochondrial 2-oxodicarboxylate carrier isoform
                     X2"
                     /calculated_mol_wt=30118
     Region          <1..75
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     Region          75..167
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     Region          175..268
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     CDS             1..269
                     /gene="SLC25A21"
                     /gene_synonym="MTDPS18; ODC; ODC1"
                     /coded_by="XM_011537288.4:294..1103"
                     /db_xref="GeneID:89874"
                     /db_xref="HGNC:HGNC:14411"
                     /db_xref="MIM:607571"
ORIGIN      
        1 mhpldvvktr fqiqrcatdp nsykslvdsf rmifqmeglf gfykgilppi laetpkravk
       61 fftfeqykkl lgyvslspal tfaiaglgsg lteaivvnpf evvkvglqan rntfaeqpst
      121 vgyarqiikk egwglqglnk gltatlgrhg vfnmvyfgfy ynvknmipvn kdpilefwrk
      181 fgigllsgti asvinipfdv aksriqgpqp vpgeikyrtc fktmatvyqe egilalykgl
      241 lpkimrlgpg gavmllvyey tyswlqenw
//
LOCUS       XP_011535591             267 aa            linear   PRI 05-AUG-2025
DEFINITION  mitochondrial 2-oxodicarboxylate carrier isoform X3 [Homo sapiens].
ACCESSION   XP_011535591
VERSION     XP_011535591.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537289.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..267
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..267
                     /product="mitochondrial 2-oxodicarboxylate carrier isoform
                     X3"
                     /calculated_mol_wt=29508
     Region          <37..73
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     Region          73..165
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     Region          173..266
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     CDS             1..267
                     /gene="SLC25A21"
                     /gene_synonym="MTDPS18; ODC; ODC1"
                     /coded_by="XM_011537289.4:190..993"
                     /db_xref="GeneID:89874"
                     /db_xref="HGNC:HGNC:14411"
                     /db_xref="MIM:607571"
ORIGIN      
        1 mclkqldgav lsrsgadlsv pqssiawiyg ksnarrlfgf ykgilppila etpkravkff
       61 tfeqykkllg yvslspaltf aiaglgsglt eaivvnpfev vkvglqanrn tfaeqpstvg
      121 yarqiikkeg wglqglnkgl tatlgrhgvf nmvyfgfyyn vknmipvnkd pilefwrkfg
      181 igllsgtias vinipfdvak sriqgpqpvp geikyrtcfk tmatvyqeeg ilalykgllp
      241 kimrlgpgga vmllvyeyty swlqenw
//
LOCUS       XP_047287828            1305 aa            linear   PRI 05-AUG-2025
DEFINITION  papilin isoform X1 [Homo sapiens].
ACCESSION   XP_047287828
VERSION     XP_047287828.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431872.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1305
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1305
                     /product="papilin isoform X1"
                     /calculated_mol_wt=140246
     Region          112..209
                     /region_name="ADAMTS_CR_3"
                     /note="ADAMTS cysteine-rich domain; pfam19236"
                     /db_xref="CDD:437068"
     Region          211..325
                     /region_name="ADAMTS_spacer1"
                     /note="ADAM-TS Spacer 1; pfam05986"
                     /db_xref="CDD:461796"
     Region          335..387
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          393..451
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          454..507
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          515..565
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          781..831
                     /region_name="Kunitz_papilin"
                     /note="Kunitz domain of papilin, and similar proteins;
                     cd22635"
                     /db_xref="CDD:438678"
     Region          841..932
                     /region_name="Papilin_u7"
                     /note="Linking region between Kunitz_BPTI and I-set on
                     papilin; pfam16626"
                     /db_xref="CDD:374683"
     Region          941..>1005
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          954..958
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          967..971
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          988..992
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          1076..1146
                     /region_name="I-set"
                     /note="Immunoglobulin I-set domain; pfam07679"
                     /db_xref="CDD:400151"
     Region          1088..1092
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          1101..1105
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          1122..1126
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          1136..1141
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          1166..1246
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          1177..1181
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          1189..1193
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          1212..1216
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          1226..1231
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          1239..1242
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          1262..1294
                     /region_name="PLAC"
                     /note="PLAC (protease and lacunin) domain; pfam08686"
                     /db_xref="CDD:462560"
     CDS             1..1305
                     /gene="PAPLN"
                     /gene_synonym="PPN"
                     /coded_by="XM_047431872.1:248..4165"
                     /db_xref="GeneID:89932"
                     /db_xref="HGNC:HGNC:19262"
                     /db_xref="MIM:617785"
ORIGIN      
        1 mqwsgpalnp nyrvgralsp asleyqhgsl tptwgiygvg sgdtlspccs hwrvpqklgp
       61 aesprtgagt lglgqvfpvl wsrrrdggss cvgparshrs crtescpdga rdfraeqcae
      121 fdgaefqgrr yrwlpyysap nkcelncipk genfyykhre avvdgtpcep gkrdvcvdgs
      181 crvvgcdhel dsskqedkcl rcggdgttcy pvagtfdand lsrgynqili vpmgatsili
      241 deaaasrnfl avknvrgeyy lnghwtieaa ralpaastil hyergaegdl aperlhargp
      301 tseplvieli sqepnpgvhy eyhlplrrps pgfswshgsw sdcsaecggg hqsrlvfcti
      361 dheaypdhmc qrqprpadrr scnlhpcpet krwkagpwap csascgggsq srsvycissd
      421 gagiqeavee aecaglpgkp paiqacnlqr caawspepwg ecsvscgvgv rkrsvtcrge
      481 rgsllhtaac sledrpplte pcvhedcpll sdqawhvgtw glcskscssg trrrqvicai
      541 gppshcgslq hskpvdvepc ntqpchlpqe vpsmqdvhtp asnpwmplgp qespasdsrg
      601 qwwaaqehps argdhrgerg dprgdqgthl salgpapslq qppyqqplrs gsgphdcrhs
      661 phgccpdght aslgpqwqgc pgapcqqsry gccpdrvsva egphhagctk syggdstggm
      721 prsravastv hnthqpqaqq nepsecrgsq fgccydnvat aagplgegcv gqpshaypvr
      781 cllpsahgsc adwaarwyfv asvgqcnrfw yggchgnann faseqecmss cqgslhgprr
      841 pqpgasgrst htdgggsspa geqepsqhrt gaavqrkpwp sgglwrqdqq pgpgeaphtq
      901 afgewpwgqe lgsrapglgg dagspappfh sssyrislag vepslvqaal gqlvrlscsd
      961 dtapesqaaw qkdgqpissd rhrlqfdgsl iihplqaeda gtyscgstrp grdsqkiqlr
     1021 iiggdmavls eaelsrfpqp rdpaqdfgqa gaagplgaip sshpqpanrl rldqnqprvv
     1081 daspgqrirm tcraegfppp aiewqrdgqp vssprhqlqp dgslvisrva vedggfytcv
     1141 afngqdrdqr wvqlrvlgel tisglpptvt vpegdtarll cvvagesvni rwsrnglpvq
     1201 adghrvhqsp dgtlliynlr ardegsytcs ayqgsqavsr stevkvvspa ptaqprdpgr
     1261 dcvdqpelan cdlilqaqlc gneyyssfcc ascsrfqpha qpiwq
//
LOCUS       XP_011535593            1278 aa            linear   PRI 05-AUG-2025
DEFINITION  papilin isoform X2 [Homo sapiens].
ACCESSION   XP_011535593
VERSION     XP_011535593.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537291.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1278
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1278
                     /product="papilin isoform X2"
                     /calculated_mol_wt=137570
     Region          29..80
                     /region_name="TSP1"
                     /note="Thrombospondin type 1 repeats; smart00209"
                     /db_xref="CDD:214559"
     Region          85..182
                     /region_name="ADAMTS_CR_3"
                     /note="ADAMTS cysteine-rich domain; pfam19236"
                     /db_xref="CDD:437068"
     Region          184..298
                     /region_name="ADAMTS_spacer1"
                     /note="ADAM-TS Spacer 1; pfam05986"
                     /db_xref="CDD:461796"
     Region          308..360
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          366..424
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          427..480
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          488..538
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          754..804
                     /region_name="Kunitz_papilin"
                     /note="Kunitz domain of papilin, and similar proteins;
                     cd22635"
                     /db_xref="CDD:438678"
     Region          814..905
                     /region_name="Papilin_u7"
                     /note="Linking region between Kunitz_BPTI and I-set on
                     papilin; pfam16626"
                     /db_xref="CDD:374683"
     Region          914..>978
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          927..931
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          940..944
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          961..965
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          1049..1119
                     /region_name="I-set"
                     /note="Immunoglobulin I-set domain; pfam07679"
                     /db_xref="CDD:400151"
     Region          1061..1065
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          1074..1078
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          1095..1099
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          1109..1114
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          1122..1125
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          1139..1219
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          1150..1154
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          1162..1166
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          1185..1189
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          1199..1204
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          1212..1215
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          1235..1267
                     /region_name="PLAC"
                     /note="PLAC (protease and lacunin) domain; pfam08686"
                     /db_xref="CDD:462560"
     CDS             1..1278
                     /gene="PAPLN"
                     /gene_synonym="PPN"
                     /coded_by="XM_011537291.4:159..3995"
                     /db_xref="GeneID:89932"
                     /db_xref="HGNC:HGNC:19262"
                     /db_xref="MIM:617785"
ORIGIN      
        1 mrllllvpll lapapgssap kvrrqsdtwg pwsqwspcsr tcgggvsfre rpcysqrrdg
       61 gsscvgpars hrscrtescp dgardfraeq caefdgaefq grryrwlpyy sapnkcelnc
      121 ipkgenfyyk hreavvdgtp cepgkrdvcv dgscrvvgcd heldsskqed kclrcggdgt
      181 tcypvagtfd andlsrgynq ilivpmgats ilideaaasr nflavknvrg eyylnghwti
      241 eaaralpaas tilhyergae gdlaperlha rgptseplvi elisqepnpg vhyeyhlplr
      301 rpspgfswsh gswsdcsaec ggghqsrlvf ctidheaypd hmcqrqprpa drrscnlhpc
      361 petkrwkagp wapcsascgg gsqsrsvyci ssdgagiqea veeaecaglp gkppaiqacn
      421 lqrcaawspe pwgecsvscg vgvrkrsvtc rgergsllht aacsledrpp ltepcvhedc
      481 pllsdqawhv gtwglcsksc ssgtrrrqvi caigppshcg slqhskpvdv epcntqpchl
      541 pqevpsmqdv htpasnpwmp lgpqespasd srgqwwaaqe hpsargdhrg ergdprgdqg
      601 thlsalgpap slqqppyqqp lrsgsgphdc rhsphgccpd ghtaslgpqw qgcpgapcqq
      661 srygccpdrv svaegphhag ctksyggdst ggmprsrava stvhnthqpq aqqnepsecr
      721 gsqfgccydn vataagplge gcvgqpshay pvrcllpsah gscadwaarw yfvasvgqcn
      781 rfwyggchgn annfaseqec msscqgslhg prrpqpgasg rsthtdgggs spageqepsq
      841 hrtgaavqrk pwpsgglwrq dqqpgpgeap htqafgewpw gqelgsrapg lggdagspap
      901 pfhsssyris lagvepslvq aalgqlvrls csddtapesq aawqkdgqpi ssdrhrlqfd
      961 gsliihplqa edagtyscgs trpgrdsqki qlriiggdma vlseaelsrf pqprdpaqdf
     1021 gqagaagplg aipsshpqpa nrlrldqnqp rvvdaspgqr irmtcraegf pppaiewqrd
     1081 gqpvssprhq lqpdgslvis rvavedggfy tcvafngqdr dqrwvqlrvl geltisglpp
     1141 tvtvpegdta rllcvvages vnirwsrngl pvqadghrvh qspdgtlliy nlrardegsy
     1201 tcsayqgsqa vsrstevkvv spaptaqprd pgrdcvdqpe lancdlilqa qlcgneyyss
     1261 fccascsrfq phaqpiwq
//
LOCUS       XP_011535594            1278 aa            linear   PRI 05-AUG-2025
DEFINITION  papilin isoform X2 [Homo sapiens].
ACCESSION   XP_011535594
VERSION     XP_011535594.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537292.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1278
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1278
                     /product="papilin isoform X2"
                     /calculated_mol_wt=137570
     Region          29..80
                     /region_name="TSP1"
                     /note="Thrombospondin type 1 repeats; smart00209"
                     /db_xref="CDD:214559"
     Region          85..182
                     /region_name="ADAMTS_CR_3"
                     /note="ADAMTS cysteine-rich domain; pfam19236"
                     /db_xref="CDD:437068"
     Region          184..298
                     /region_name="ADAMTS_spacer1"
                     /note="ADAM-TS Spacer 1; pfam05986"
                     /db_xref="CDD:461796"
     Region          308..360
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          366..424
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          427..480
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          488..538
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          754..804
                     /region_name="Kunitz_papilin"
                     /note="Kunitz domain of papilin, and similar proteins;
                     cd22635"
                     /db_xref="CDD:438678"
     Region          814..905
                     /region_name="Papilin_u7"
                     /note="Linking region between Kunitz_BPTI and I-set on
                     papilin; pfam16626"
                     /db_xref="CDD:374683"
     Region          914..>978
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          927..931
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          940..944
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          961..965
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          1049..1119
                     /region_name="I-set"
                     /note="Immunoglobulin I-set domain; pfam07679"
                     /db_xref="CDD:400151"
     Region          1061..1065
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          1074..1078
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          1095..1099
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          1109..1114
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          1122..1125
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          1139..1219
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          1150..1154
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          1162..1166
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          1185..1189
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          1199..1204
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          1212..1215
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          1235..1267
                     /region_name="PLAC"
                     /note="PLAC (protease and lacunin) domain; pfam08686"
                     /db_xref="CDD:462560"
     CDS             1..1278
                     /gene="PAPLN"
                     /gene_synonym="PPN"
                     /coded_by="XM_011537292.4:63..3899"
                     /db_xref="GeneID:89932"
                     /db_xref="HGNC:HGNC:19262"
                     /db_xref="MIM:617785"
ORIGIN      
        1 mrllllvpll lapapgssap kvrrqsdtwg pwsqwspcsr tcgggvsfre rpcysqrrdg
       61 gsscvgpars hrscrtescp dgardfraeq caefdgaefq grryrwlpyy sapnkcelnc
      121 ipkgenfyyk hreavvdgtp cepgkrdvcv dgscrvvgcd heldsskqed kclrcggdgt
      181 tcypvagtfd andlsrgynq ilivpmgats ilideaaasr nflavknvrg eyylnghwti
      241 eaaralpaas tilhyergae gdlaperlha rgptseplvi elisqepnpg vhyeyhlplr
      301 rpspgfswsh gswsdcsaec ggghqsrlvf ctidheaypd hmcqrqprpa drrscnlhpc
      361 petkrwkagp wapcsascgg gsqsrsvyci ssdgagiqea veeaecaglp gkppaiqacn
      421 lqrcaawspe pwgecsvscg vgvrkrsvtc rgergsllht aacsledrpp ltepcvhedc
      481 pllsdqawhv gtwglcsksc ssgtrrrqvi caigppshcg slqhskpvdv epcntqpchl
      541 pqevpsmqdv htpasnpwmp lgpqespasd srgqwwaaqe hpsargdhrg ergdprgdqg
      601 thlsalgpap slqqppyqqp lrsgsgphdc rhsphgccpd ghtaslgpqw qgcpgapcqq
      661 srygccpdrv svaegphhag ctksyggdst ggmprsrava stvhnthqpq aqqnepsecr
      721 gsqfgccydn vataagplge gcvgqpshay pvrcllpsah gscadwaarw yfvasvgqcn
      781 rfwyggchgn annfaseqec msscqgslhg prrpqpgasg rsthtdgggs spageqepsq
      841 hrtgaavqrk pwpsgglwrq dqqpgpgeap htqafgewpw gqelgsrapg lggdagspap
      901 pfhsssyris lagvepslvq aalgqlvrls csddtapesq aawqkdgqpi ssdrhrlqfd
      961 gsliihplqa edagtyscgs trpgrdsqki qlriiggdma vlseaelsrf pqprdpaqdf
     1021 gqagaagplg aipsshpqpa nrlrldqnqp rvvdaspgqr irmtcraegf pppaiewqrd
     1081 gqpvssprhq lqpdgslvis rvavedggfy tcvafngqdr dqrwvqlrvl geltisglpp
     1141 tvtvpegdta rllcvvages vnirwsrngl pvqadghrvh qspdgtlliy nlrardegsy
     1201 tcsayqgsqa vsrstevkvv spaptaqprd pgrdcvdqpe lancdlilqa qlcgneyyss
     1261 fccascsrfq phaqpiwq
//
LOCUS       XP_011535595            1259 aa            linear   PRI 05-AUG-2025
DEFINITION  papilin isoform X3 [Homo sapiens].
ACCESSION   XP_011535595
VERSION     XP_011535595.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537293.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XP_011535595.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1259
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1259
                     /product="papilin isoform X3"
                     /calculated_mol_wt=134750
     Region          112..209
                     /region_name="ADAMTS_CR_3"
                     /note="ADAMTS cysteine-rich domain; pfam19236"
                     /db_xref="CDD:437068"
     Region          211..325
                     /region_name="ADAMTS_spacer1"
                     /note="ADAM-TS Spacer 1; pfam05986"
                     /db_xref="CDD:461796"
     Region          335..387
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          393..451
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          454..507
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          515..565
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          781..831
                     /region_name="Kunitz_papilin"
                     /note="Kunitz domain of papilin, and similar proteins;
                     cd22635"
                     /db_xref="CDD:438678"
     Region          841..932
                     /region_name="Papilin_u7"
                     /note="Linking region between Kunitz_BPTI and I-set on
                     papilin; pfam16626"
                     /db_xref="CDD:374683"
     Region          941..>1005
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          954..958
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          967..971
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          988..992
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          1076..1146
                     /region_name="I-set"
                     /note="Immunoglobulin I-set domain; pfam07679"
                     /db_xref="CDD:400151"
     Region          1088..1092
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          1101..1105
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          1122..1126
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          1136..1141
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          1166..>1214
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     CDS             1..1259
                     /gene="PAPLN"
                     /gene_synonym="PPN"
                     /coded_by="XM_011537293.4:146..3925"
                     /db_xref="GeneID:89932"
                     /db_xref="HGNC:HGNC:19262"
                     /db_xref="MIM:617785"
ORIGIN      
        1 mqwsgpalnp nyrvgralsp asleyqhgsl tptwgiygvg sgdtlspccs hwrvpqklgp
       61 aesprtgagt lglgqvfpvl wsrrrdggss cvgparshrs crtescpdga rdfraeqcae
      121 fdgaefqgrr yrwlpyysap nkcelncipk genfyykhre avvdgtpcep gkrdvcvdgs
      181 crvvgcdhel dsskqedkcl rcggdgttcy pvagtfdand lsrgynqili vpmgatsili
      241 deaaasrnfl avknvrgeyy lnghwtieaa ralpaastil hyergaegdl aperlhargp
      301 tseplvieli sqepnpgvhy eyhlplrrps pgfswshgsw sdcsaecggg hqsrlvfcti
      361 dheaypdhmc qrqprpadrr scnlhpcpet krwkagpwap csascgggsq srsvycissd
      421 gagiqeavee aecaglpgkp paiqacnlqr caawspepwg ecsvscgvgv rkrsvtcrge
      481 rgsllhtaac sledrpplte pcvhedcpll sdqawhvgtw glcskscssg trrrqvicai
      541 gppshcgslq hskpvdvepc ntqpchlpqe vpsmqdvhtp asnpwmplgp qespasdsrg
      601 qwwaaqehps argdhrgerg dprgdqgthl salgpapslq qppyqqplrs gsgphdcrhs
      661 phgccpdght aslgpqwqgc pgapcqqsry gccpdrvsva egphhagctk syggdstggm
      721 prsravastv hnthqpqaqq nepsecrgsq fgccydnvat aagplgegcv gqpshaypvr
      781 cllpsahgsc adwaarwyfv asvgqcnrfw yggchgnann faseqecmss cqgslhgprr
      841 pqpgasgrst htdgggsspa geqepsqhrt gaavqrkpwp sgglwrqdqq pgpgeaphtq
      901 afgewpwgqe lgsrapglgg dagspappfh sssyrislag vepslvqaal gqlvrlscsd
      961 dtapesqaaw qkdgqpissd rhrlqfdgsl iihplqaeda gtyscgstrp grdsqkiqlr
     1021 iiggdmavls eaelsrfpqp rdpaqdfgqa gaagplgaip sshpqpanrl rldqnqprvv
     1081 daspgqrirm tcraegfppp aiewqrdgqp vssprhqlqp dgslvisrva vedggfytcv
     1141 afngqdrdqr wvqlrvlgel tisglpptvt vpegdtarll cvvagesvni rwsrppeald
     1201 gspsvlsppg tgylcrlmat vstspqmarc sfttcgpgmr aptravptrg arqsaaapr
//
LOCUS       XP_011535596            1234 aa            linear   PRI 05-AUG-2025
DEFINITION  papilin isoform X4 [Homo sapiens].
ACCESSION   XP_011535596
VERSION     XP_011535596.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537294.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1234
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1234
                     /product="papilin isoform X4"
                     /calculated_mol_wt=132648
     Region          41..138
                     /region_name="ADAMTS_CR_3"
                     /note="ADAMTS cysteine-rich domain; pfam19236"
                     /db_xref="CDD:437068"
     Region          140..254
                     /region_name="ADAMTS_spacer1"
                     /note="ADAM-TS Spacer 1; pfam05986"
                     /db_xref="CDD:461796"
     Region          264..316
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          322..380
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          383..436
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          444..494
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          710..760
                     /region_name="Kunitz_papilin"
                     /note="Kunitz domain of papilin, and similar proteins;
                     cd22635"
                     /db_xref="CDD:438678"
     Region          770..861
                     /region_name="Papilin_u7"
                     /note="Linking region between Kunitz_BPTI and I-set on
                     papilin; pfam16626"
                     /db_xref="CDD:374683"
     Region          870..>934
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          883..887
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          896..900
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          917..921
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          1005..1075
                     /region_name="I-set"
                     /note="Immunoglobulin I-set domain; pfam07679"
                     /db_xref="CDD:400151"
     Region          1017..1021
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          1030..1034
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          1051..1055
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          1065..1070
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          1095..1175
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          1106..1110
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          1118..1122
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          1141..1145
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          1155..1160
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          1168..1171
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          1191..1223
                     /region_name="PLAC"
                     /note="PLAC (protease and lacunin) domain; pfam08686"
                     /db_xref="CDD:462560"
     CDS             1..1234
                     /gene="PAPLN"
                     /gene_synonym="PPN"
                     /coded_by="XM_011537294.3:159..3863"
                     /db_xref="GeneID:89932"
                     /db_xref="HGNC:HGNC:19262"
                     /db_xref="MIM:617785"
ORIGIN      
        1 mscldrrmav psgrdggssc vgparshrsc rtescpdgar dfraeqcaef dgaefqgrry
       61 rwlpyysapn kcelncipkg enfyykhrea vvdgtpcepg krdvcvdgsc rvvgcdheld
      121 sskqedkclr cggdgttcyp vagtfdandl srgynqiliv pmgatsilid eaaasrnfla
      181 vknvrgeyyl nghwtieaar alpaastilh yergaegdla perlhargpt seplvielis
      241 qepnpgvhye yhlplrrpsp gfswshgsws dcsaecgggh qsrlvfctid heaypdhmcq
      301 rqprpadrrs cnlhpcpetk rwkagpwapc sascgggsqs rsvycissdg agiqeaveea
      361 ecaglpgkpp aiqacnlqrc aawspepwge csvscgvgvr krsvtcrger gsllhtaacs
      421 ledrppltep cvhedcplls dqawhvgtwg lcskscssgt rrrqvicaig ppshcgslqh
      481 skpvdvepcn tqpchlpqev psmqdvhtpa snpwmplgpq espasdsrgq wwaaqehpsa
      541 rgdhrgergd prgdqgthls algpapslqq ppyqqplrsg sgphdcrhsp hgccpdghta
      601 slgpqwqgcp gapcqqsryg ccpdrvsvae gphhagctks yggdstggmp rsravastvh
      661 nthqpqaqqn epsecrgsqf gccydnvata agplgegcvg qpshaypvrc llpsahgsca
      721 dwaarwyfva svgqcnrfwy ggchgnannf aseqecmssc qgslhgprrp qpgasgrsth
      781 tdgggsspag eqepsqhrtg aavqrkpwps gglwrqdqqp gpgeaphtqa fgewpwgqel
      841 gsrapglggd agspappfhs ssyrislagv epslvqaalg qlvrlscsdd tapesqaawq
      901 kdgqpissdr hrlqfdgsli ihplqaedag tyscgstrpg rdsqkiqlri iggdmavlse
      961 aelsrfpqpr dpaqdfgqag aagplgaips shpqpanrlr ldqnqprvvd aspgqrirmt
     1021 craegfpppa iewqrdgqpv ssprhqlqpd gslvisrvav edggfytcva fngqdrdqrw
     1081 vqlrvlgelt isglpptvtv pegdtarllc vvagesvnir wsrnglpvqa dghrvhqspd
     1141 gtlliynlra rdegsytcsa yqgsqavsrs tevkvvspap taqprdpgrd cvdqpelanc
     1201 dlilqaqlcg neyyssfcca scsrfqphaq piwq
//
LOCUS       XP_047287829            1226 aa            linear   PRI 05-AUG-2025
DEFINITION  papilin isoform X5 [Homo sapiens].
ACCESSION   XP_047287829
VERSION     XP_047287829.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431873.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1226
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1226
                     /product="papilin isoform X5"
                     /calculated_mol_wt=131614
     Region          112..209
                     /region_name="ADAMTS_CR_3"
                     /note="ADAMTS cysteine-rich domain; pfam19236"
                     /db_xref="CDD:437068"
     Region          211..325
                     /region_name="ADAMTS_spacer1"
                     /note="ADAM-TS Spacer 1; pfam05986"
                     /db_xref="CDD:461796"
     Region          335..387
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          393..451
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          454..507
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          515..565
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          781..831
                     /region_name="Kunitz_papilin"
                     /note="Kunitz domain of papilin, and similar proteins;
                     cd22635"
                     /db_xref="CDD:438678"
     Region          841..932
                     /region_name="Papilin_u7"
                     /note="Linking region between Kunitz_BPTI and I-set on
                     papilin; pfam16626"
                     /db_xref="CDD:374683"
     Region          941..>1005
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          954..958
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          967..971
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          988..992
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          1076..1167
                     /region_name="I-set"
                     /note="Immunoglobulin I-set domain; pfam07679"
                     /db_xref="CDD:400151"
     Region          1088..1092
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          1101..1105
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          1133..1137
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          1147..1152
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          1160..1163
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          1183..1215
                     /region_name="PLAC"
                     /note="PLAC (protease and lacunin) domain; pfam08686"
                     /db_xref="CDD:462560"
     CDS             1..1226
                     /gene="PAPLN"
                     /gene_synonym="PPN"
                     /coded_by="XM_047431873.1:146..3826"
                     /db_xref="GeneID:89932"
                     /db_xref="HGNC:HGNC:19262"
                     /db_xref="MIM:617785"
ORIGIN      
        1 mqwsgpalnp nyrvgralsp asleyqhgsl tptwgiygvg sgdtlspccs hwrvpqklgp
       61 aesprtgagt lglgqvfpvl wsrrrdggss cvgparshrs crtescpdga rdfraeqcae
      121 fdgaefqgrr yrwlpyysap nkcelncipk genfyykhre avvdgtpcep gkrdvcvdgs
      181 crvvgcdhel dsskqedkcl rcggdgttcy pvagtfdand lsrgynqili vpmgatsili
      241 deaaasrnfl avknvrgeyy lnghwtieaa ralpaastil hyergaegdl aperlhargp
      301 tseplvieli sqepnpgvhy eyhlplrrps pgfswshgsw sdcsaecggg hqsrlvfcti
      361 dheaypdhmc qrqprpadrr scnlhpcpet krwkagpwap csascgggsq srsvycissd
      421 gagiqeavee aecaglpgkp paiqacnlqr caawspepwg ecsvscgvgv rkrsvtcrge
      481 rgsllhtaac sledrpplte pcvhedcpll sdqawhvgtw glcskscssg trrrqvicai
      541 gppshcgslq hskpvdvepc ntqpchlpqe vpsmqdvhtp asnpwmplgp qespasdsrg
      601 qwwaaqehps argdhrgerg dprgdqgthl salgpapslq qppyqqplrs gsgphdcrhs
      661 phgccpdght aslgpqwqgc pgapcqqsry gccpdrvsva egphhagctk syggdstggm
      721 prsravastv hnthqpqaqq nepsecrgsq fgccydnvat aagplgegcv gqpshaypvr
      781 cllpsahgsc adwaarwyfv asvgqcnrfw yggchgnann faseqecmss cqgslhgprr
      841 pqpgasgrst htdgggsspa geqepsqhrt gaavqrkpwp sgglwrqdqq pgpgeaphtq
      901 afgewpwgqe lgsrapglgg dagspappfh sssyrislag vepslvqaal gqlvrlscsd
      961 dtapesqaaw qkdgqpissd rhrlqfdgsl iihplqaeda gtyscgstrp grdsqkiqlr
     1021 iiggdmavls eaelsrfpqp rdpaqdfgqa gaagplgaip sshpqpanrl rldqnqprvv
     1081 daspgqrirm tcraegfppp aiewqrdgqp vssprnglpv qadghrvhqs pdgtlliynl
     1141 rardegsytc sayqgsqavs rstevkvvsp aptaqprdpg rdcvdqpela ncdlilqaql
     1201 cgneyyssfc cascsrfqph aqpiwq
//
LOCUS       XP_047287830            1199 aa            linear   PRI 05-AUG-2025
DEFINITION  papilin isoform X6 [Homo sapiens].
ACCESSION   XP_047287830
VERSION     XP_047287830.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431874.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1199
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1199
                     /product="papilin isoform X6"
                     /calculated_mol_wt=128937
     Region          29..80
                     /region_name="TSP1"
                     /note="Thrombospondin type 1 repeats; smart00209"
                     /db_xref="CDD:214559"
     Region          85..182
                     /region_name="ADAMTS_CR_3"
                     /note="ADAMTS cysteine-rich domain; pfam19236"
                     /db_xref="CDD:437068"
     Region          184..298
                     /region_name="ADAMTS_spacer1"
                     /note="ADAM-TS Spacer 1; pfam05986"
                     /db_xref="CDD:461796"
     Region          308..360
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          366..424
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          427..480
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          488..538
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          754..804
                     /region_name="Kunitz_papilin"
                     /note="Kunitz domain of papilin, and similar proteins;
                     cd22635"
                     /db_xref="CDD:438678"
     Region          814..905
                     /region_name="Papilin_u7"
                     /note="Linking region between Kunitz_BPTI and I-set on
                     papilin; pfam16626"
                     /db_xref="CDD:374683"
     Region          914..>978
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          927..931
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          940..944
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          961..965
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          1049..1140
                     /region_name="I-set"
                     /note="Immunoglobulin I-set domain; pfam07679"
                     /db_xref="CDD:400151"
     Region          1061..1065
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          1074..1078
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          1106..1110
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          1120..1125
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          1133..1136
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          1156..1188
                     /region_name="PLAC"
                     /note="PLAC (protease and lacunin) domain; pfam08686"
                     /db_xref="CDD:462560"
     CDS             1..1199
                     /gene="PAPLN"
                     /gene_synonym="PPN"
                     /coded_by="XM_047431874.1:94..3693"
                     /db_xref="GeneID:89932"
                     /db_xref="HGNC:HGNC:19262"
                     /db_xref="MIM:617785"
ORIGIN      
        1 mrllllvpll lapapgssap kvrrqsdtwg pwsqwspcsr tcgggvsfre rpcysqrrdg
       61 gsscvgpars hrscrtescp dgardfraeq caefdgaefq grryrwlpyy sapnkcelnc
      121 ipkgenfyyk hreavvdgtp cepgkrdvcv dgscrvvgcd heldsskqed kclrcggdgt
      181 tcypvagtfd andlsrgynq ilivpmgats ilideaaasr nflavknvrg eyylnghwti
      241 eaaralpaas tilhyergae gdlaperlha rgptseplvi elisqepnpg vhyeyhlplr
      301 rpspgfswsh gswsdcsaec ggghqsrlvf ctidheaypd hmcqrqprpa drrscnlhpc
      361 petkrwkagp wapcsascgg gsqsrsvyci ssdgagiqea veeaecaglp gkppaiqacn
      421 lqrcaawspe pwgecsvscg vgvrkrsvtc rgergsllht aacsledrpp ltepcvhedc
      481 pllsdqawhv gtwglcsksc ssgtrrrqvi caigppshcg slqhskpvdv epcntqpchl
      541 pqevpsmqdv htpasnpwmp lgpqespasd srgqwwaaqe hpsargdhrg ergdprgdqg
      601 thlsalgpap slqqppyqqp lrsgsgphdc rhsphgccpd ghtaslgpqw qgcpgapcqq
      661 srygccpdrv svaegphhag ctksyggdst ggmprsrava stvhnthqpq aqqnepsecr
      721 gsqfgccydn vataagplge gcvgqpshay pvrcllpsah gscadwaarw yfvasvgqcn
      781 rfwyggchgn annfaseqec msscqgslhg prrpqpgasg rsthtdgggs spageqepsq
      841 hrtgaavqrk pwpsgglwrq dqqpgpgeap htqafgewpw gqelgsrapg lggdagspap
      901 pfhsssyris lagvepslvq aalgqlvrls csddtapesq aawqkdgqpi ssdrhrlqfd
      961 gsliihplqa edagtyscgs trpgrdsqki qlriiggdma vlseaelsrf pqprdpaqdf
     1021 gqagaagplg aipsshpqpa nrlrldqnqp rvvdaspgqr irmtcraegf pppaiewqrd
     1081 gqpvssprng lpvqadghrv hqspdgtlli ynlrardegs ytcsayqgsq avsrstevkv
     1141 vspaptaqpr dpgrdcvdqp elancdlilq aqlcgneyys sfccascsrf qphaqpiwq
//
LOCUS       XP_016877238            1180 aa            linear   PRI 05-AUG-2025
DEFINITION  papilin isoform X7 [Homo sapiens].
ACCESSION   XP_016877238
VERSION     XP_016877238.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021749.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XP_016877238.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1180
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1180
                     /product="papilin isoform X7"
                     /calculated_mol_wt=126117
     Region          112..209
                     /region_name="ADAMTS_CR_3"
                     /note="ADAMTS cysteine-rich domain; pfam19236"
                     /db_xref="CDD:437068"
     Region          211..325
                     /region_name="ADAMTS_spacer1"
                     /note="ADAM-TS Spacer 1; pfam05986"
                     /db_xref="CDD:461796"
     Region          335..387
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          393..451
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          454..507
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          515..565
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          781..831
                     /region_name="Kunitz_papilin"
                     /note="Kunitz domain of papilin, and similar proteins;
                     cd22635"
                     /db_xref="CDD:438678"
     Region          841..932
                     /region_name="Papilin_u7"
                     /note="Linking region between Kunitz_BPTI and I-set on
                     papilin; pfam16626"
                     /db_xref="CDD:374683"
     Region          941..>1005
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          954..958
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          967..971
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          988..992
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          1076..>1113
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          1088..1092
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:143224"
     Region          1101..1105
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:143224"
     CDS             1..1180
                     /gene="PAPLN"
                     /gene_synonym="PPN"
                     /coded_by="XM_017021749.3:146..3688"
                     /db_xref="GeneID:89932"
                     /db_xref="HGNC:HGNC:19262"
                     /db_xref="MIM:617785"
ORIGIN      
        1 mqwsgpalnp nyrvgralsp asleyqhgsl tptwgiygvg sgdtlspccs hwrvpqklgp
       61 aesprtgagt lglgqvfpvl wsrrrdggss cvgparshrs crtescpdga rdfraeqcae
      121 fdgaefqgrr yrwlpyysap nkcelncipk genfyykhre avvdgtpcep gkrdvcvdgs
      181 crvvgcdhel dsskqedkcl rcggdgttcy pvagtfdand lsrgynqili vpmgatsili
      241 deaaasrnfl avknvrgeyy lnghwtieaa ralpaastil hyergaegdl aperlhargp
      301 tseplvieli sqepnpgvhy eyhlplrrps pgfswshgsw sdcsaecggg hqsrlvfcti
      361 dheaypdhmc qrqprpadrr scnlhpcpet krwkagpwap csascgggsq srsvycissd
      421 gagiqeavee aecaglpgkp paiqacnlqr caawspepwg ecsvscgvgv rkrsvtcrge
      481 rgsllhtaac sledrpplte pcvhedcpll sdqawhvgtw glcskscssg trrrqvicai
      541 gppshcgslq hskpvdvepc ntqpchlpqe vpsmqdvhtp asnpwmplgp qespasdsrg
      601 qwwaaqehps argdhrgerg dprgdqgthl salgpapslq qppyqqplrs gsgphdcrhs
      661 phgccpdght aslgpqwqgc pgapcqqsry gccpdrvsva egphhagctk syggdstggm
      721 prsravastv hnthqpqaqq nepsecrgsq fgccydnvat aagplgegcv gqpshaypvr
      781 cllpsahgsc adwaarwyfv asvgqcnrfw yggchgnann faseqecmss cqgslhgprr
      841 pqpgasgrst htdgggsspa geqepsqhrt gaavqrkpwp sgglwrqdqq pgpgeaphtq
      901 afgewpwgqe lgsrapglgg dagspappfh sssyrislag vepslvqaal gqlvrlscsd
      961 dtapesqaaw qkdgqpissd rhrlqfdgsl iihplqaeda gtyscgstrp grdsqkiqlr
     1021 iiggdmavls eaelsrfpqp rdpaqdfgqa gaagplgaip sshpqpanrl rldqnqprvv
     1081 daspgqrirm tcraegfppp aiewqrdgqp vssprppeal dgspsvlspp gtgylcrlma
     1141 tvstspqmar csfttcgpgm raptravptr garqsaaapr
//
LOCUS       XP_047287831            1285 aa            linear   PRI 05-AUG-2025
DEFINITION  papilin isoform X8 [Homo sapiens].
ACCESSION   XP_047287831
VERSION     XP_047287831.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431875.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1285
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1285
                     /product="papilin isoform X8"
                     /calculated_mol_wt=138396
     Region          36..87
                     /region_name="TSP1"
                     /note="Thrombospondin type 1 repeats; smart00209"
                     /db_xref="CDD:214559"
     Region          92..189
                     /region_name="ADAMTS_CR_3"
                     /note="ADAMTS cysteine-rich domain; pfam19236"
                     /db_xref="CDD:437068"
     Region          191..305
                     /region_name="ADAMTS_spacer1"
                     /note="ADAM-TS Spacer 1; pfam05986"
                     /db_xref="CDD:461796"
     Region          315..367
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          373..431
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          434..487
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          495..545
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          761..811
                     /region_name="Kunitz_papilin"
                     /note="Kunitz domain of papilin, and similar proteins;
                     cd22635"
                     /db_xref="CDD:438678"
     Region          821..912
                     /region_name="Papilin_u7"
                     /note="Linking region between Kunitz_BPTI and I-set on
                     papilin; pfam16626"
                     /db_xref="CDD:374683"
     Region          921..>985
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          934..938
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          947..951
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          968..972
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          1056..1126
                     /region_name="I-set"
                     /note="Immunoglobulin I-set domain; pfam07679"
                     /db_xref="CDD:400151"
     Region          1068..1072
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          1081..1085
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          1102..1106
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          1116..1121
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          1146..1226
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          1157..1161
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          1169..1173
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          1192..1196
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          1206..1211
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          1219..1222
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          1242..1274
                     /region_name="PLAC"
                     /note="PLAC (protease and lacunin) domain; pfam08686"
                     /db_xref="CDD:462560"
     CDS             1..1285
                     /gene="PAPLN"
                     /gene_synonym="PPN"
                     /coded_by="XM_047431875.1:148..4005"
                     /db_xref="GeneID:89932"
                     /db_xref="HGNC:HGNC:19262"
                     /db_xref="MIM:617785"
ORIGIN      
        1 mrlpqaemrl lllvplllap apgssapkvr rqsdtwgpws qwspcsrtcg ggvsfrerpc
       61 ysqrrdggss cvgparshrs crtescpdga rdfraeqcae fdgaefqgrr yrwlpyysap
      121 nkcelncipk genfyykhre avvdgtpcep gkrdvcvdgs crvvgcdhel dsskqedkcl
      181 rcggdgttcy pvagtfdand lsrgynqili vpmgatsili deaaasrnfl avknvrgeyy
      241 lnghwtieaa ralpaastil hyergaegdl aperlhargp tseplvieli sqepnpgvhy
      301 eyhlplrrps pgfswshgsw sdcsaecggg hqsrlvfcti dheaypdhmc qrqprpadrr
      361 scnlhpcpet krwkagpwap csascgggsq srsvycissd gagiqeavee aecaglpgkp
      421 paiqacnlqr caawspepwg ecsvscgvgv rkrsvtcrge rgsllhtaac sledrpplte
      481 pcvhedcpll sdqawhvgtw glcskscssg trrrqvicai gppshcgslq hskpvdvepc
      541 ntqpchlpqe vpsmqdvhtp asnpwmplgp qespasdsrg qwwaaqehps argdhrgerg
      601 dprgdqgthl salgpapslq qppyqqplrs gsgphdcrhs phgccpdght aslgpqwqgc
      661 pgapcqqsry gccpdrvsva egphhagctk syggdstggm prsravastv hnthqpqaqq
      721 nepsecrgsq fgccydnvat aagplgegcv gqpshaypvr cllpsahgsc adwaarwyfv
      781 asvgqcnrfw yggchgnann faseqecmss cqgslhgprr pqpgasgrst htdgggsspa
      841 geqepsqhrt gaavqrkpwp sgglwrqdqq pgpgeaphtq afgewpwgqe lgsrapglgg
      901 dagspappfh sssyrislag vepslvqaal gqlvrlscsd dtapesqaaw qkdgqpissd
      961 rhrlqfdgsl iihplqaeda gtyscgstrp grdsqkiqlr iiggdmavls eaelsrfpqp
     1021 rdpaqdfgqa gaagplgaip sshpqpanrl rldqnqprvv daspgqrirm tcraegfppp
     1081 aiewqrdgqp vssprhqlqp dgslvisrva vedggfytcv afngqdrdqr wvqlrvlgel
     1141 tisglpptvt vpegdtarll cvvagesvni rwsrnglpvq adghrvhqsp dgtlliynlr
     1201 ardegsytcs ayqgsqavsr stevkvvspa ptaqprdpgr dcvdqpelan cdlilqaqlc
     1261 gneyyssfcc ascsrfqpha qpiwq
//
LOCUS       XP_011535598            1031 aa            linear   PRI 05-AUG-2025
DEFINITION  papilin isoform X9 [Homo sapiens].
ACCESSION   XP_011535598
VERSION     XP_011535598.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537296.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XP_011535598.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1031
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1031
                     /product="papilin isoform X9"
                     /calculated_mol_wt=110495
     Region          112..209
                     /region_name="ADAMTS_CR_3"
                     /note="ADAMTS cysteine-rich domain; pfam19236"
                     /db_xref="CDD:437068"
     Region          211..325
                     /region_name="ADAMTS_spacer1"
                     /note="ADAM-TS Spacer 1; pfam05986"
                     /db_xref="CDD:461796"
     Region          335..387
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          393..451
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          454..507
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          515..565
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          781..831
                     /region_name="Kunitz_papilin"
                     /note="Kunitz domain of papilin, and similar proteins;
                     cd22635"
                     /db_xref="CDD:438678"
     Region          841..932
                     /region_name="Papilin_u7"
                     /note="Linking region between Kunitz_BPTI and I-set on
                     papilin; pfam16626"
                     /db_xref="CDD:374683"
     Region          941..>1005
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          954..958
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          967..971
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          988..992
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     CDS             1..1031
                     /gene="PAPLN"
                     /gene_synonym="PPN"
                     /coded_by="XM_011537296.3:146..3241"
                     /db_xref="GeneID:89932"
                     /db_xref="HGNC:HGNC:19262"
                     /db_xref="MIM:617785"
ORIGIN      
        1 mqwsgpalnp nyrvgralsp asleyqhgsl tptwgiygvg sgdtlspccs hwrvpqklgp
       61 aesprtgagt lglgqvfpvl wsrrrdggss cvgparshrs crtescpdga rdfraeqcae
      121 fdgaefqgrr yrwlpyysap nkcelncipk genfyykhre avvdgtpcep gkrdvcvdgs
      181 crvvgcdhel dsskqedkcl rcggdgttcy pvagtfdand lsrgynqili vpmgatsili
      241 deaaasrnfl avknvrgeyy lnghwtieaa ralpaastil hyergaegdl aperlhargp
      301 tseplvieli sqepnpgvhy eyhlplrrps pgfswshgsw sdcsaecggg hqsrlvfcti
      361 dheaypdhmc qrqprpadrr scnlhpcpet krwkagpwap csascgggsq srsvycissd
      421 gagiqeavee aecaglpgkp paiqacnlqr caawspepwg ecsvscgvgv rkrsvtcrge
      481 rgsllhtaac sledrpplte pcvhedcpll sdqawhvgtw glcskscssg trrrqvicai
      541 gppshcgslq hskpvdvepc ntqpchlpqe vpsmqdvhtp asnpwmplgp qespasdsrg
      601 qwwaaqehps argdhrgerg dprgdqgthl salgpapslq qppyqqplrs gsgphdcrhs
      661 phgccpdght aslgpqwqgc pgapcqqsry gccpdrvsva egphhagctk syggdstggm
      721 prsravastv hnthqpqaqq nepsecrgsq fgccydnvat aagplgegcv gqpshaypvr
      781 cllpsahgsc adwaarwyfv asvgqcnrfw yggchgnann faseqecmss cqgslhgprr
      841 pqpgasgrst htdgggsspa geqepsqhrt gaavqrkpwp sgglwrqdqq pgpgeaphtq
      901 afgewpwgqe lgsrapglgg dagspappfh sssyrislag vepslvqaal gqlvrlscsd
      961 dtapesqaaw qkdgqpissd rhrlqfdgsl iihplqaeda gtyscgstrp grdsqkiqlr
     1021 iiahtlflla s
//
LOCUS       XP_047287832             830 aa            linear   PRI 05-AUG-2025
DEFINITION  papilin isoform X10 [Homo sapiens].
ACCESSION   XP_047287832
VERSION     XP_047287832.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431876.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..830
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..830
                     /product="papilin isoform X10"
                     /calculated_mol_wt=89253
     Region          112..209
                     /region_name="ADAMTS_CR_3"
                     /note="ADAMTS cysteine-rich domain; pfam19236"
                     /db_xref="CDD:437068"
     Region          211..325
                     /region_name="ADAMTS_spacer1"
                     /note="ADAM-TS Spacer 1; pfam05986"
                     /db_xref="CDD:461796"
     Region          335..387
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          393..451
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          454..507
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          515..565
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     CDS             1..830
                     /gene="PAPLN"
                     /gene_synonym="PPN"
                     /coded_by="XM_047431876.1:146..2638"
                     /db_xref="GeneID:89932"
                     /db_xref="HGNC:HGNC:19262"
                     /db_xref="MIM:617785"
ORIGIN      
        1 mqwsgpalnp nyrvgralsp asleyqhgsl tptwgiygvg sgdtlspccs hwrvpqklgp
       61 aesprtgagt lglgqvfpvl wsrrrdggss cvgparshrs crtescpdga rdfraeqcae
      121 fdgaefqgrr yrwlpyysap nkcelncipk genfyykhre avvdgtpcep gkrdvcvdgs
      181 crvvgcdhel dsskqedkcl rcggdgttcy pvagtfdand lsrgynqili vpmgatsili
      241 deaaasrnfl avknvrgeyy lnghwtieaa ralpaastil hyergaegdl aperlhargp
      301 tseplvieli sqepnpgvhy eyhlplrrps pgfswshgsw sdcsaecggg hqsrlvfcti
      361 dheaypdhmc qrqprpadrr scnlhpcpet krwkagpwap csascgggsq srsvycissd
      421 gagiqeavee aecaglpgkp paiqacnlqr caawspepwg ecsvscgvgv rkrsvtcrge
      481 rgsllhtaac sledrpplte pcvhedcpll sdqawhvgtw glcskscssg trrrqvicai
      541 gppshcgslq hskpvdvepc ntqpchlpqe vpsmqdvhtp asnpwmplgp qespasdsrg
      601 qwwaaqehps argdhrgerg dprgdqgthl salgpapslq qppyqqplrs gsgphdcrhs
      661 phgccpdght aslgpqwqgc pgapcqqsry gccpdrvsva egphhagctk syggdstggm
      721 prsravastv hnthqpqaqq nepsecrgsq fgccydnvat aagplgegcv gqpshglawq
      781 vwsprwcrqp wgswcgspaq ttlprnprlp grkmaspspl tgtgcsstdp
//
LOCUS       XP_047287833             732 aa            linear   PRI 05-AUG-2025
DEFINITION  papilin isoform X11 [Homo sapiens].
ACCESSION   XP_047287833
VERSION     XP_047287833.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431877.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..732
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..732
                     /product="papilin isoform X11"
                     /calculated_mol_wt=78048
     Region          208..258
                     /region_name="Kunitz_papilin"
                     /note="Kunitz domain of papilin, and similar proteins;
                     cd22635"
                     /db_xref="CDD:438678"
     Region          268..359
                     /region_name="Papilin_u7"
                     /note="Linking region between Kunitz_BPTI and I-set on
                     papilin; pfam16626"
                     /db_xref="CDD:374683"
     Region          368..>432
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          381..385
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          394..398
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          415..419
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          503..573
                     /region_name="I-set"
                     /note="Immunoglobulin I-set domain; pfam07679"
                     /db_xref="CDD:400151"
     Region          515..519
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          528..532
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          549..553
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          563..568
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          593..673
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          604..608
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          616..620
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          639..643
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          653..658
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          666..669
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          689..721
                     /region_name="PLAC"
                     /note="PLAC (protease and lacunin) domain; pfam08686"
                     /db_xref="CDD:462560"
     CDS             1..732
                     /gene="PAPLN"
                     /gene_synonym="PPN"
                     /coded_by="XM_047431877.1:709..2907"
                     /db_xref="GeneID:89932"
                     /db_xref="HGNC:HGNC:19262"
                     /db_xref="MIM:617785"
ORIGIN      
        1 mqdvhtpasn pwmplgpqes pasdsrgqww aaqehpsarg dhrgergdpr gdqgthlsal
       61 gpapslqqpp yqqplrsgsg phdcrhsphg ccpdghtasl gpqwqgcpga pcqqsrygcc
      121 pdrvsvaegp hhagctksyg gdstggmprs ravastvhnt hqpqaqqnep secrgsqfgc
      181 cydnvataag plgegcvgqp shaypvrcll psahgscadw aarwyfvasv gqcnrfwygg
      241 chgnannfas eqecmsscqg slhgprrpqp gasgrsthtd gggsspageq epsqhrtgaa
      301 vqrkpwpsgg lwrqdqqpgp geaphtqafg ewpwgqelgs rapglggdag spappfhsss
      361 yrislagvep slvqaalgql vrlscsddta pesqaawqkd gqpissdrhr lqfdgsliih
      421 plqaedagty scgstrpgrd sqkiqlriig gdmavlseae lsrfpqprdp aqdfgqagaa
      481 gplgaipssh pqpanrlrld qnqprvvdas pgqrirmtcr aegfpppaie wqrdgqpvss
      541 prhqlqpdgs lvisrvaved ggfytcvafn gqdrdqrwvq lrvlgeltis glpptvtvpe
      601 gdtarllcvv agesvnirws rnglpvqadg hrvhqspdgt lliynlrard egsytcsayq
      661 gsqavsrste vkvvspapta qprdpgrdcv dqpelancdl ilqaqlcgne yyssfccasc
      721 srfqphaqpi wq
//
LOCUS       XP_047287835             349 aa            linear   PRI 05-AUG-2025
DEFINITION  Y+L amino acid transporter 1 isoform X2 [Homo sapiens].
ACCESSION   XP_047287835
VERSION     XP_047287835.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431879.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..349
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..349
                     /product="Y+L amino acid transporter 1 isoform X2"
                     /calculated_mol_wt=38931
     Region          <4..331
                     /region_name="2A0308"
                     /note="L-type amino acid transporter; TIGR00911"
                     /db_xref="CDD:273332"
     CDS             1..349
                     /gene="SLC7A7"
                     /gene_synonym="LAT3; LPI; MOP-2; y+LAT-1; Y+LAT1"
                     /coded_by="XM_047431879.1:159..1208"
                     /db_xref="GeneID:9056"
                     /db_xref="HGNC:HGNC:11065"
                     /db_xref="MIM:603593"
ORIGIN      
        1 myflclltfi ncayvkwgtl vqdiftyakv laliavivag ivrlgqgast hfensfegss
       61 favgdialal ysalfsysgw dtlnyvteei knpernlpls igismpivti iyiltnvayy
      121 tvldmrdila sdavavtfad qifgifnwii plsvalscfg glnasivaas rlffvgsreg
      181 hlpdaicmih verftpvpsl lfngimaliy lcvedifqli nyysfsywff vglsivgqly
      241 lrwkepdrpr plklsvffpi vfclctiflv avplysdtin sligiaials glpfyfliir
      301 vpehkrplyl rrivgsatry lqvlcmsvaa emdledggem pkqrdpksn
//
LOCUS       XP_047287836            1374 aa            linear   PRI 05-AUG-2025
DEFINITION  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X1
            [Homo sapiens].
ACCESSION   XP_047287836
VERSION     XP_047287836.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431880.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1374
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1374
                     /product="capping protein, Arp2/3 and myosin-I linker
                     protein 3 isoform X1"
                     /calculated_mol_wt=150299
     Region          31..118
                     /region_name="Carm_PH"
                     /note="Carmil pleckstrin homology domain; pfam17888"
                     /db_xref="CDD:436119"
     Region          245..273
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          <274..657
                     /region_name="RNA1"
                     /note="Ran GTPase-activating protein (RanGAP) involved in
                     mRNA processing and transport [Translation, ribosomal
                     structure and biogenesis]; COG5238"
                     /db_xref="CDD:444072"
     Region          275..303
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          304..335
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          336..365
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          366..391
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          393..420
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          425..452
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          453..479
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          480..509
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          544..570
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          571..593
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          778..1067
                     /region_name="CARMIL_C"
                     /note="CARMIL C-terminus; pfam16000"
                     /db_xref="CDD:464966"
     Region          <1122..1338
                     /region_name="PRK07764"
                     /note="DNA polymerase III subunits gamma and tau;
                     Validated"
                     /db_xref="CDD:236090"
     CDS             1..1374
                     /gene="CARMIL3"
                     /gene_synonym="C14orf121; crml-1; LRRC16B"
                     /coded_by="XM_047431880.1:146..4270"
                     /db_xref="GeneID:90668"
                     /db_xref="HGNC:HGNC:20272"
                     /db_xref="MIM:614716"
ORIGIN      
        1 makpsveltr elqdsirrcl sqgavlqqhh vkletkpkkf edrvlaltsw rlhlfllkvp
       61 akvessfnvl eirafntlsq nqilveterg mvsmrlpsae svdqvtrhvs salskvcpgp
      121 gclirrgnad tpegprdtsp nsetststth svcggfsety aalcdynglh creevqwdvd
      181 tiyhaednre fnlldfshle srdlalmvaa laynqwftkl yckdlrlgse vleqvlhtls
      241 ksgsleelvl dnaglktdfv qklagvfgen gscvlhaltl shnpiedkgf lslsqqllcf
      301 psgltklcla ktaisprglq algqtfganp afasslryld lsknpgllat deanalysfl
      361 aqpnalvhld lsgtdcvidl llgallhgcc shltylnlar nscshrkgre appafkqffs
      421 saytlshvnl satklpleal rallqglsln shlsdlhldl sscelrsaga qalqeqlgav
      481 tcvgsldlsd ngfdsdlltl vpalgknksl khlflgknfn vkaktleeil hklvqliqee
      541 dcslqslsva dsrlklrtsi linalgsntc lakvdlsgng medigakmls kalqinsslr
      601 tilwdrnnts algfldiara lesnhtlrfm sfpvsdisqa yrsaperted vwqkiqwclv
      661 rnnhsqtcpq eqafrlqqgl vtssaeqmlq rlcgrvqeev ralrlcplep vqdellyard
      721 likdaknsra lfpslyelgh vlandgpvrq rlesvasevs kavdkelqvi lesmvsltqe
      781 lcpvamrvae ghnkmlsnva ervtvprnfi rgalleqagq diqnkldevk lsvvtyltss
      841 ivdeilqely hshkslarhl tqlrtlsdpp gcpgqgqdls srgrgrnhdh eettddelgt
      901 nidtmaikkq krcrkirpvs afisgspqdm esqlgnlgip pgwfsglggs qptasgsweg
      961 lselpthgyk lrhqtqgrpr pprttppgpg rpsqmpapgt rqengmatrl degledffsr
     1021 rvleesssyp rtlrtvrpgl seaplpplqk krrrglfhfr rprsfkgdrg pgspttglll
     1081 pppppppptq esppspdpps lgnnsspcws peeessllpg fgggrgpsfr rkmgtegsep
     1141 geggpapgta qqprvhgval pglerakgws fdgkregpgp dqegstqawq krrssddagp
     1201 gswkpppppq stkpsfsamr raeatwhiae esapnhscqs pspasqdgee ekegtlfper
     1261 tlparnaklq dpalapwppk pvavprgrqp pqepgvreea eagdaapgvn kprlrlssqq
     1321 dqeepevqgp pdpgrrtapl kpkrtrraqs cdklepdrrr ppdptagtse pgtd
//
LOCUS       XP_047287837            1373 aa            linear   PRI 05-AUG-2025
DEFINITION  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X2
            [Homo sapiens].
ACCESSION   XP_047287837
VERSION     XP_047287837.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431881.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1373
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1373
                     /product="capping protein, Arp2/3 and myosin-I linker
                     protein 3 isoform X2"
                     /calculated_mol_wt=150170
     Region          31..118
                     /region_name="Carm_PH"
                     /note="Carmil pleckstrin homology domain; pfam17888"
                     /db_xref="CDD:436119"
     Region          245..273
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          <274..657
                     /region_name="RNA1"
                     /note="Ran GTPase-activating protein (RanGAP) involved in
                     mRNA processing and transport [Translation, ribosomal
                     structure and biogenesis]; COG5238"
                     /db_xref="CDD:444072"
     Region          275..303
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          304..335
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          336..365
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          366..391
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          393..420
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          425..452
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          453..479
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          480..509
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          544..570
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          571..593
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          778..1066
                     /region_name="CARMIL_C"
                     /note="CARMIL C-terminus; pfam16000"
                     /db_xref="CDD:464966"
     Region          <1121..1337
                     /region_name="PRK07764"
                     /note="DNA polymerase III subunits gamma and tau;
                     Validated"
                     /db_xref="CDD:236090"
     CDS             1..1373
                     /gene="CARMIL3"
                     /gene_synonym="C14orf121; crml-1; LRRC16B"
                     /coded_by="XM_047431881.1:146..4267"
                     /db_xref="GeneID:90668"
                     /db_xref="HGNC:HGNC:20272"
                     /db_xref="MIM:614716"
ORIGIN      
        1 makpsveltr elqdsirrcl sqgavlqqhh vkletkpkkf edrvlaltsw rlhlfllkvp
       61 akvessfnvl eirafntlsq nqilveterg mvsmrlpsae svdqvtrhvs salskvcpgp
      121 gclirrgnad tpegprdtsp nsetststth svcggfsety aalcdynglh creevqwdvd
      181 tiyhaednre fnlldfshle srdlalmvaa laynqwftkl yckdlrlgse vleqvlhtls
      241 ksgsleelvl dnaglktdfv qklagvfgen gscvlhaltl shnpiedkgf lslsqqllcf
      301 psgltklcla ktaisprglq algqtfganp afasslryld lsknpgllat deanalysfl
      361 aqpnalvhld lsgtdcvidl llgallhgcc shltylnlar nscshrkgre appafkqffs
      421 saytlshvnl satklpleal rallqglsln shlsdlhldl sscelrsaga qalqeqlgav
      481 tcvgsldlsd ngfdsdlltl vpalgknksl khlflgknfn vkaktleeil hklvqliqee
      541 dcslqslsva dsrlklrtsi linalgsntc lakvdlsgng medigakmls kalqinsslr
      601 tilwdrnnts algfldiara lesnhtlrfm sfpvsdisqa yrsaperted vwqkiqwclv
      661 rnnhsqtcpq eqafrlqqgl vtssaeqmlq rlcgrvqeev ralrlcplep vqdellyard
      721 likdaknsra lfpslyelgh vlandgpvrq rlesvasevs kavdkelqvi lesmvsltqe
      781 lcpvamrvae ghnkmlsnva ervtvprnfi rgalleqagq diqnkldevk lsvvtyltss
      841 ivdeilqely hshkslarhl tqlrtlsdpp gcpgqgqdls srgrgrnhdh eettddelgt
      901 nidtmaikkq krcrkirpvs afisgspqdm esqlgnlgip pgwfsglggs qptasgsweg
      961 lselpthgyk lrhqtqgrpr pprttppgpg rpsmpapgtr qengmatrld egledffsrr
     1021 vleesssypr tlrtvrpgls eaplpplqkk rrrglfhfrr prsfkgdrgp gspttglllp
     1081 ppppppptqe sppspdppsl gnnsspcwsp eeessllpgf gggrgpsfrr kmgtegsepg
     1141 eggpapgtaq qprvhgvalp glerakgwsf dgkregpgpd qegstqawqk rrssddagpg
     1201 swkpppppqs tkpsfsamrr aeatwhiaee sapnhscqsp spasqdgeee kegtlfpert
     1261 lparnaklqd palapwppkp vavprgrqpp qepgvreeae agdaapgvnk prlrlssqqd
     1321 qeepevqgpp dpgrrtaplk pkrtrraqsc dklepdrrrp pdptagtsep gtd
//
LOCUS       XP_047287838            1373 aa            linear   PRI 05-AUG-2025
DEFINITION  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X3
            [Homo sapiens].
ACCESSION   XP_047287838
VERSION     XP_047287838.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431882.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1373
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1373
                     /product="capping protein, Arp2/3 and myosin-I linker
                     protein 3 isoform X3"
                     /calculated_mol_wt=150228
     Region          31..118
                     /region_name="Carm_PH"
                     /note="Carmil pleckstrin homology domain; pfam17888"
                     /db_xref="CDD:436119"
     Region          245..273
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          <274..657
                     /region_name="RNA1"
                     /note="Ran GTPase-activating protein (RanGAP) involved in
                     mRNA processing and transport [Translation, ribosomal
                     structure and biogenesis]; COG5238"
                     /db_xref="CDD:444072"
     Region          275..303
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          304..335
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          336..365
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          366..391
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          393..420
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          425..452
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          453..479
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          480..509
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          544..570
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          571..593
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          778..1067
                     /region_name="CARMIL_C"
                     /note="CARMIL C-terminus; pfam16000"
                     /db_xref="CDD:464966"
     Region          <1122..1338
                     /region_name="PRK07764"
                     /note="DNA polymerase III subunits gamma and tau;
                     Validated"
                     /db_xref="CDD:236090"
     CDS             1..1373
                     /gene="CARMIL3"
                     /gene_synonym="C14orf121; crml-1; LRRC16B"
                     /coded_by="XM_047431882.1:146..4267"
                     /db_xref="GeneID:90668"
                     /db_xref="HGNC:HGNC:20272"
                     /db_xref="MIM:614716"
ORIGIN      
        1 makpsveltr elqdsirrcl sqgavlqqhh vkletkpkkf edrvlaltsw rlhlfllkvp
       61 akvessfnvl eirafntlsq nqilveterg mvsmrlpsae svdqvtrhvs salskvcpgp
      121 gclirrgnad tpegprdtsp nsetststth svcggfsety aalcdynglh creevqwdvd
      181 tiyhaednre fnlldfshle srdlalmvaa laynqwftkl yckdlrlgse vleqvlhtls
      241 ksgsleelvl dnaglktdfv qklagvfgen gscvlhaltl shnpiedkgf lslsqqllcf
      301 psgltklcla ktaisprglq algqtfganp afasslryld lsknpgllat deanalysfl
      361 aqpnalvhld lsgtdcvidl llgallhgcc shltylnlar nscshrkgre appafkqffs
      421 saytlshvnl satklpleal rallqglsln shlsdlhldl sscelrsaga qalqeqlgav
      481 tcvgsldlsd ngfdsdlltl vpalgknksl khlflgknfn vkaktleeil hklvqliqee
      541 dcslqslsva dsrlklrtsi linalgsntc lakvdlsgng medigakmls kalqinsslr
      601 tilwdrnnts algfldiara lesnhtlrfm sfpvsdisqa yrsaperted vwqkiqwclv
      661 rnnhsqtcpq eqafrlqqgl vtssaeqmlq rlcgrvqeev ralrlcplep vqdellyard
      721 likdaknsra lfpslyelgh vlandgpvrq rlesvasevs kavdkelqvi lesmvsltqe
      781 lcpvamrvae ghnkmlsnva ervtvprnfi rgalleqagq diqnkldevk lsvvtyltss
      841 ivdeilqely hshkslarhl tqlrtlsdpp gcpgqgqdls srgrgrnhdh eettddelgt
      901 nidtmaikkq krcrkirpvs afisgspqdm esqlgnlgip pgwfsglggs qptasgsweg
      961 lselpthgyk lrhqtqgrpr pprttppgpg rpsqmpapgt rqengmatrl degledffsr
     1021 rvleesssyp rtlrtvrpgl seaplpplqk krrrglfhfr rprsfkgdrg pgspttglll
     1081 pppppppptq esppspdpps lgnnsspcws peeessllpg fgggrgpsfr rkmgtegsep
     1141 geggpapgta qqprvhgval pglerakgws fdgkregpgp dqegstqawq krrssddagp
     1201 gswkpppppq stkpsfsamr raeatwhiae esapnhscqs pspasqdgee ekegtlfper
     1261 tlparnaklq dpalapwppk pvavprgrqp pqepgvreea eagdaapgvn kprlrlssqq
     1321 dqeepevqgp pdpgrrtapl kpkrtrraqs cdklepdrrr ppdptgtsep gtd
//
LOCUS       XP_047287839            1372 aa            linear   PRI 05-AUG-2025
DEFINITION  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X4
            [Homo sapiens].
ACCESSION   XP_047287839
VERSION     XP_047287839.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431883.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1372
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1372
                     /product="capping protein, Arp2/3 and myosin-I linker
                     protein 3 isoform X4"
                     /calculated_mol_wt=150057
     Region          31..118
                     /region_name="Carm_PH"
                     /note="Carmil pleckstrin homology domain; pfam17888"
                     /db_xref="CDD:436119"
     Region          245..273
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          <274..657
                     /region_name="RNA1"
                     /note="Ran GTPase-activating protein (RanGAP) involved in
                     mRNA processing and transport [Translation, ribosomal
                     structure and biogenesis]; COG5238"
                     /db_xref="CDD:444072"
     Region          275..303
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          304..335
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          336..365
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          366..391
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          393..420
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          425..452
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          453..479
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          480..509
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          544..570
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          571..593
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          778..1067
                     /region_name="CARMIL_C"
                     /note="CARMIL C-terminus; pfam16000"
                     /db_xref="CDD:464966"
     Region          <1122..1336
                     /region_name="PRK07764"
                     /note="DNA polymerase III subunits gamma and tau;
                     Validated"
                     /db_xref="CDD:236090"
     CDS             1..1372
                     /gene="CARMIL3"
                     /gene_synonym="C14orf121; crml-1; LRRC16B"
                     /coded_by="XM_047431883.1:146..4264"
                     /db_xref="GeneID:90668"
                     /db_xref="HGNC:HGNC:20272"
                     /db_xref="MIM:614716"
ORIGIN      
        1 makpsveltr elqdsirrcl sqgavlqqhh vkletkpkkf edrvlaltsw rlhlfllkvp
       61 akvessfnvl eirafntlsq nqilveterg mvsmrlpsae svdqvtrhvs salskvcpgp
      121 gclirrgnad tpegprdtsp nsetststth svcggfsety aalcdynglh creevqwdvd
      181 tiyhaednre fnlldfshle srdlalmvaa laynqwftkl yckdlrlgse vleqvlhtls
      241 ksgsleelvl dnaglktdfv qklagvfgen gscvlhaltl shnpiedkgf lslsqqllcf
      301 psgltklcla ktaisprglq algqtfganp afasslryld lsknpgllat deanalysfl
      361 aqpnalvhld lsgtdcvidl llgallhgcc shltylnlar nscshrkgre appafkqffs
      421 saytlshvnl satklpleal rallqglsln shlsdlhldl sscelrsaga qalqeqlgav
      481 tcvgsldlsd ngfdsdlltl vpalgknksl khlflgknfn vkaktleeil hklvqliqee
      541 dcslqslsva dsrlklrtsi linalgsntc lakvdlsgng medigakmls kalqinsslr
      601 tilwdrnnts algfldiara lesnhtlrfm sfpvsdisqa yrsaperted vwqkiqwclv
      661 rnnhsqtcpq eqafrlqqgl vtssaeqmlq rlcgrvqeev ralrlcplep vqdellyard
      721 likdaknsra lfpslyelgh vlandgpvrq rlesvasevs kavdkelqvi lesmvsltqe
      781 lcpvamrvae ghnkmlsnva ervtvprnfi rgalleqagq diqnkldevk lsvvtyltss
      841 ivdeilqely hshkslarhl tqlrtlsdpp gcpgqgqdls srgrgrnhdh eettddelgt
      901 nidtmaikkq krcrkirpvs afisgspqdm esqlgnlgip pgwfsglggs qptasgsweg
      961 lselpthgyk lrhqtqgrpr pprttppgpg rpsqmpapgt rqengmatrl degledffsr
     1021 rvleesssyp rtlrtvrpgl seaplpplqk krrrglfhfr rprsfkgdrg pgspttglll
     1081 pppppppptq esppspdpps lgnnsspcws peeessllpg fgggrgpsfr rkmgtegsep
     1141 geggpapgta qqprvhgval pglerakgws fdgkregpgp dqegstqawq krrssddagp
     1201 gswkpppppq stkpsfsamr raeatwhiae esapnhscqs pspasqdgee ekegtlfper
     1261 tlparnakdp alapwppkpv avprgrqppq epgvreeaea gdaapgvnkp rlrlssqqdq
     1321 eepevqgppd pgrrtaplkp krtrraqscd klepdrrrpp dptagtsepg td
//
LOCUS       XP_047287840            1371 aa            linear   PRI 05-AUG-2025
DEFINITION  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X5
            [Homo sapiens].
ACCESSION   XP_047287840
VERSION     XP_047287840.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431884.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1371
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1371
                     /product="capping protein, Arp2/3 and myosin-I linker
                     protein 3 isoform X5"
                     /calculated_mol_wt=149929
     Region          31..118
                     /region_name="Carm_PH"
                     /note="Carmil pleckstrin homology domain; pfam17888"
                     /db_xref="CDD:436119"
     Region          245..273
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          <274..657
                     /region_name="RNA1"
                     /note="Ran GTPase-activating protein (RanGAP) involved in
                     mRNA processing and transport [Translation, ribosomal
                     structure and biogenesis]; COG5238"
                     /db_xref="CDD:444072"
     Region          275..303
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          304..335
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          336..365
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          366..391
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          393..420
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          425..452
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          453..479
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          480..509
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          544..570
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          571..593
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          778..1066
                     /region_name="CARMIL_C"
                     /note="CARMIL C-terminus; pfam16000"
                     /db_xref="CDD:464966"
     Region          <1121..1335
                     /region_name="PRK07764"
                     /note="DNA polymerase III subunits gamma and tau;
                     Validated"
                     /db_xref="CDD:236090"
     CDS             1..1371
                     /gene="CARMIL3"
                     /gene_synonym="C14orf121; crml-1; LRRC16B"
                     /coded_by="XM_047431884.1:146..4261"
                     /db_xref="GeneID:90668"
                     /db_xref="HGNC:HGNC:20272"
                     /db_xref="MIM:614716"
ORIGIN      
        1 makpsveltr elqdsirrcl sqgavlqqhh vkletkpkkf edrvlaltsw rlhlfllkvp
       61 akvessfnvl eirafntlsq nqilveterg mvsmrlpsae svdqvtrhvs salskvcpgp
      121 gclirrgnad tpegprdtsp nsetststth svcggfsety aalcdynglh creevqwdvd
      181 tiyhaednre fnlldfshle srdlalmvaa laynqwftkl yckdlrlgse vleqvlhtls
      241 ksgsleelvl dnaglktdfv qklagvfgen gscvlhaltl shnpiedkgf lslsqqllcf
      301 psgltklcla ktaisprglq algqtfganp afasslryld lsknpgllat deanalysfl
      361 aqpnalvhld lsgtdcvidl llgallhgcc shltylnlar nscshrkgre appafkqffs
      421 saytlshvnl satklpleal rallqglsln shlsdlhldl sscelrsaga qalqeqlgav
      481 tcvgsldlsd ngfdsdlltl vpalgknksl khlflgknfn vkaktleeil hklvqliqee
      541 dcslqslsva dsrlklrtsi linalgsntc lakvdlsgng medigakmls kalqinsslr
      601 tilwdrnnts algfldiara lesnhtlrfm sfpvsdisqa yrsaperted vwqkiqwclv
      661 rnnhsqtcpq eqafrlqqgl vtssaeqmlq rlcgrvqeev ralrlcplep vqdellyard
      721 likdaknsra lfpslyelgh vlandgpvrq rlesvasevs kavdkelqvi lesmvsltqe
      781 lcpvamrvae ghnkmlsnva ervtvprnfi rgalleqagq diqnkldevk lsvvtyltss
      841 ivdeilqely hshkslarhl tqlrtlsdpp gcpgqgqdls srgrgrnhdh eettddelgt
      901 nidtmaikkq krcrkirpvs afisgspqdm esqlgnlgip pgwfsglggs qptasgsweg
      961 lselpthgyk lrhqtqgrpr pprttppgpg rpsmpapgtr qengmatrld egledffsrr
     1021 vleesssypr tlrtvrpgls eaplpplqkk rrrglfhfrr prsfkgdrgp gspttglllp
     1081 ppppppptqe sppspdppsl gnnsspcwsp eeessllpgf gggrgpsfrr kmgtegsepg
     1141 eggpapgtaq qprvhgvalp glerakgwsf dgkregpgpd qegstqawqk rrssddagpg
     1201 swkpppppqs tkpsfsamrr aeatwhiaee sapnhscqsp spasqdgeee kegtlfpert
     1261 lparnakdpa lapwppkpva vprgrqppqe pgvreeaeag daapgvnkpr lrlssqqdqe
     1321 epevqgppdp grrtaplkpk rtrraqscdk lepdrrrppd ptagtsepgt d
//
LOCUS       XP_047287841            1371 aa            linear   PRI 05-AUG-2025
DEFINITION  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X6
            [Homo sapiens].
ACCESSION   XP_047287841
VERSION     XP_047287841.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431885.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1371
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1371
                     /product="capping protein, Arp2/3 and myosin-I linker
                     protein 3 isoform X6"
                     /calculated_mol_wt=149986
     Region          31..118
                     /region_name="Carm_PH"
                     /note="Carmil pleckstrin homology domain; pfam17888"
                     /db_xref="CDD:436119"
     Region          245..273
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          <274..657
                     /region_name="RNA1"
                     /note="Ran GTPase-activating protein (RanGAP) involved in
                     mRNA processing and transport [Translation, ribosomal
                     structure and biogenesis]; COG5238"
                     /db_xref="CDD:444072"
     Region          275..303
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          304..335
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          336..365
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          366..391
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          393..420
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          425..452
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          453..479
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          480..509
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          544..570
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          571..593
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          778..1067
                     /region_name="CARMIL_C"
                     /note="CARMIL C-terminus; pfam16000"
                     /db_xref="CDD:464966"
     Region          <1188..>1369
                     /region_name="PRK12323"
                     /note="DNA polymerase III subunit gamma/tau; cl46901"
                     /db_xref="CDD:481241"
     CDS             1..1371
                     /gene="CARMIL3"
                     /gene_synonym="C14orf121; crml-1; LRRC16B"
                     /coded_by="XM_047431885.1:146..4261"
                     /db_xref="GeneID:90668"
                     /db_xref="HGNC:HGNC:20272"
                     /db_xref="MIM:614716"
ORIGIN      
        1 makpsveltr elqdsirrcl sqgavlqqhh vkletkpkkf edrvlaltsw rlhlfllkvp
       61 akvessfnvl eirafntlsq nqilveterg mvsmrlpsae svdqvtrhvs salskvcpgp
      121 gclirrgnad tpegprdtsp nsetststth svcggfsety aalcdynglh creevqwdvd
      181 tiyhaednre fnlldfshle srdlalmvaa laynqwftkl yckdlrlgse vleqvlhtls
      241 ksgsleelvl dnaglktdfv qklagvfgen gscvlhaltl shnpiedkgf lslsqqllcf
      301 psgltklcla ktaisprglq algqtfganp afasslryld lsknpgllat deanalysfl
      361 aqpnalvhld lsgtdcvidl llgallhgcc shltylnlar nscshrkgre appafkqffs
      421 saytlshvnl satklpleal rallqglsln shlsdlhldl sscelrsaga qalqeqlgav
      481 tcvgsldlsd ngfdsdlltl vpalgknksl khlflgknfn vkaktleeil hklvqliqee
      541 dcslqslsva dsrlklrtsi linalgsntc lakvdlsgng medigakmls kalqinsslr
      601 tilwdrnnts algfldiara lesnhtlrfm sfpvsdisqa yrsaperted vwqkiqwclv
      661 rnnhsqtcpq eqafrlqqgl vtssaeqmlq rlcgrvqeev ralrlcplep vqdellyard
      721 likdaknsra lfpslyelgh vlandgpvrq rlesvasevs kavdkelqvi lesmvsltqe
      781 lcpvamrvae ghnkmlsnva ervtvprnfi rgalleqagq diqnkldevk lsvvtyltss
      841 ivdeilqely hshkslarhl tqlrtlsdpp gcpgqgqdls srgrgrnhdh eettddelgt
      901 nidtmaikkq krcrkirpvs afisgspqdm esqlgnlgip pgwfsglggs qptasgsweg
      961 lselpthgyk lrhqtqgrpr pprttppgpg rpsqmpapgt rqengmatrl degledffsr
     1021 rvleesssyp rtlrtvrpgl seaplpplqk krrrglfhfr rprsfkgdrg pgspttglll
     1081 pppppppptq esppspdpps lgnnsspcws peeessllpg fgggrgpsfr rkmgtegsep
     1141 geggpapgta qqprvhgval pglerakgws fdgkregpgp dqegstqawq krrssddagp
     1201 gswkpppppq stkpsfsamr raeatwhiae esapnhscqs pspasqdgee ekegtlfper
     1261 tlparnakdp alapwppkpv avprgrqppq epgvreeaea gdaapgvnkp rlrlssqqdq
     1321 eepevqgppd pgrrtaplkp krtrraqscd klepdrrrpp dptgtsepgt d
//
LOCUS       XP_047287842            1370 aa            linear   PRI 05-AUG-2025
DEFINITION  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X7
            [Homo sapiens].
ACCESSION   XP_047287842
VERSION     XP_047287842.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431886.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1370
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1370
                     /product="capping protein, Arp2/3 and myosin-I linker
                     protein 3 isoform X7"
                     /calculated_mol_wt=149858
     Region          31..118
                     /region_name="Carm_PH"
                     /note="Carmil pleckstrin homology domain; pfam17888"
                     /db_xref="CDD:436119"
     Region          245..273
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          <274..657
                     /region_name="RNA1"
                     /note="Ran GTPase-activating protein (RanGAP) involved in
                     mRNA processing and transport [Translation, ribosomal
                     structure and biogenesis]; COG5238"
                     /db_xref="CDD:444072"
     Region          275..303
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          304..335
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          336..365
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          366..391
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          393..420
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          425..452
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          453..479
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          480..509
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          544..570
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          571..593
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          778..1066
                     /region_name="CARMIL_C"
                     /note="CARMIL C-terminus; pfam16000"
                     /db_xref="CDD:464966"
     Region          <1122..1370
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..1370
                     /gene="CARMIL3"
                     /gene_synonym="C14orf121; crml-1; LRRC16B"
                     /coded_by="XM_047431886.1:146..4258"
                     /db_xref="GeneID:90668"
                     /db_xref="HGNC:HGNC:20272"
                     /db_xref="MIM:614716"
ORIGIN      
        1 makpsveltr elqdsirrcl sqgavlqqhh vkletkpkkf edrvlaltsw rlhlfllkvp
       61 akvessfnvl eirafntlsq nqilveterg mvsmrlpsae svdqvtrhvs salskvcpgp
      121 gclirrgnad tpegprdtsp nsetststth svcggfsety aalcdynglh creevqwdvd
      181 tiyhaednre fnlldfshle srdlalmvaa laynqwftkl yckdlrlgse vleqvlhtls
      241 ksgsleelvl dnaglktdfv qklagvfgen gscvlhaltl shnpiedkgf lslsqqllcf
      301 psgltklcla ktaisprglq algqtfganp afasslryld lsknpgllat deanalysfl
      361 aqpnalvhld lsgtdcvidl llgallhgcc shltylnlar nscshrkgre appafkqffs
      421 saytlshvnl satklpleal rallqglsln shlsdlhldl sscelrsaga qalqeqlgav
      481 tcvgsldlsd ngfdsdlltl vpalgknksl khlflgknfn vkaktleeil hklvqliqee
      541 dcslqslsva dsrlklrtsi linalgsntc lakvdlsgng medigakmls kalqinsslr
      601 tilwdrnnts algfldiara lesnhtlrfm sfpvsdisqa yrsaperted vwqkiqwclv
      661 rnnhsqtcpq eqafrlqqgl vtssaeqmlq rlcgrvqeev ralrlcplep vqdellyard
      721 likdaknsra lfpslyelgh vlandgpvrq rlesvasevs kavdkelqvi lesmvsltqe
      781 lcpvamrvae ghnkmlsnva ervtvprnfi rgalleqagq diqnkldevk lsvvtyltss
      841 ivdeilqely hshkslarhl tqlrtlsdpp gcpgqgqdls srgrgrnhdh eettddelgt
      901 nidtmaikkq krcrkirpvs afisgspqdm esqlgnlgip pgwfsglggs qptasgsweg
      961 lselpthgyk lrhqtqgrpr pprttppgpg rpsmpapgtr qengmatrld egledffsrr
     1021 vleesssypr tlrtvrpgls eaplpplqkk rrrglfhfrr prsfkgdrgp gspttglllp
     1081 ppppppptqe sppspdppsl gnnsspcwsp eeessllpgf gggrgpsfrr kmgtegsepg
     1141 eggpapgtaq qprvhgvalp glerakgwsf dgkregpgpd qegstqawqk rrssddagpg
     1201 swkpppppqs tkpsfsamrr aeatwhiaee sapnhscqsp spasqdgeee kegtlfpert
     1261 lparnakdpa lapwppkpva vprgrqppqe pgvreeaeag daapgvnkpr lrlssqqdqe
     1321 epevqgppdp grrtaplkpk rtrraqscdk lepdrrrppd ptgtsepgtd
//
LOCUS       XP_047287843            1331 aa            linear   PRI 05-AUG-2025
DEFINITION  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X8
            [Homo sapiens].
ACCESSION   XP_047287843
VERSION     XP_047287843.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431887.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1331
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1331
                     /product="capping protein, Arp2/3 and myosin-I linker
                     protein 3 isoform X8"
                     /calculated_mol_wt=145945
     Region          31..118
                     /region_name="Carm_PH"
                     /note="Carmil pleckstrin homology domain; pfam17888"
                     /db_xref="CDD:436119"
     Region          245..273
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          <274..657
                     /region_name="RNA1"
                     /note="Ran GTPase-activating protein (RanGAP) involved in
                     mRNA processing and transport [Translation, ribosomal
                     structure and biogenesis]; COG5238"
                     /db_xref="CDD:444072"
     Region          275..303
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          304..335
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          336..365
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          366..391
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          393..420
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          425..452
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          453..479
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          480..509
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          544..570
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          571..593
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          778..1067
                     /region_name="CARMIL_C"
                     /note="CARMIL C-terminus; pfam16000"
                     /db_xref="CDD:464966"
     Region          <1133..1318
                     /region_name="PspC_subgroup_2"
                     /note="pneumococcal surface protein PspC, LPXTG-anchored
                     form; NF033839"
                     /db_xref="CDD:468202"
     CDS             1..1331
                     /gene="CARMIL3"
                     /gene_synonym="C14orf121; crml-1; LRRC16B"
                     /coded_by="XM_047431887.1:146..4141"
                     /db_xref="GeneID:90668"
                     /db_xref="HGNC:HGNC:20272"
                     /db_xref="MIM:614716"
ORIGIN      
        1 makpsveltr elqdsirrcl sqgavlqqhh vkletkpkkf edrvlaltsw rlhlfllkvp
       61 akvessfnvl eirafntlsq nqilveterg mvsmrlpsae svdqvtrhvs salskvcpgp
      121 gclirrgnad tpegprdtsp nsetststth svcggfsety aalcdynglh creevqwdvd
      181 tiyhaednre fnlldfshle srdlalmvaa laynqwftkl yckdlrlgse vleqvlhtls
      241 ksgsleelvl dnaglktdfv qklagvfgen gscvlhaltl shnpiedkgf lslsqqllcf
      301 psgltklcla ktaisprglq algqtfganp afasslryld lsknpgllat deanalysfl
      361 aqpnalvhld lsgtdcvidl llgallhgcc shltylnlar nscshrkgre appafkqffs
      421 saytlshvnl satklpleal rallqglsln shlsdlhldl sscelrsaga qalqeqlgav
      481 tcvgsldlsd ngfdsdlltl vpalgknksl khlflgknfn vkaktleeil hklvqliqee
      541 dcslqslsva dsrlklrtsi linalgsntc lakvdlsgng medigakmls kalqinsslr
      601 tilwdrnnts algfldiara lesnhtlrfm sfpvsdisqa yrsaperted vwqkiqwclv
      661 rnnhsqtcpq eqafrlqqgl vtssaeqmlq rlcgrvqeev ralrlcplep vqdellyard
      721 likdaknsra lfpslyelgh vlandgpvrq rlesvasevs kavdkelqvi lesmvsltqe
      781 lcpvamrvae ghnkmlsnva ervtvprnfi rgalleqagq diqnkldevk lsvvtyltss
      841 ivdeilqely hshkslarhl tqlrtlsdpp gcpgqgqdls srgrgrnhdh eettddelgt
      901 nidtmaikkq krcrkirpvs afisgspqdm esqlgnlgip pgwfsglggs qptasgsweg
      961 lselpthgyk lrhqtqgrpr pprttppgpg rpsqmpapgt rqengmatrl degledffsr
     1021 rvleesssyp rtlrtvrpgl seaplpplqk krrrglfhfr rprsfkgdrg pgspttglll
     1081 pppppppptq esppspdpps lgnnsspcws peeessllpg fgggrgpsfr rkmgpgpdqe
     1141 gstqawqkrr ssddagpgsw kpppppqstk psfsamrrae atwhiaeesa pnhscqspsp
     1201 asqdgeeeke gtlfpertlp arnaklqdpa lapwppkpva vprgrqppqe pgvreeaeag
     1261 daapgvnkpr lrlssqqdqe epevqgppdp grrtaplkpk rtrraqscdk lepdrrrppd
     1321 ptagtsepgt d
//
LOCUS       XP_047287844            1330 aa            linear   PRI 05-AUG-2025
DEFINITION  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X9
            [Homo sapiens].
ACCESSION   XP_047287844
VERSION     XP_047287844.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431888.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1330
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1330
                     /product="capping protein, Arp2/3 and myosin-I linker
                     protein 3 isoform X9"
                     /calculated_mol_wt=145817
     Region          31..118
                     /region_name="Carm_PH"
                     /note="Carmil pleckstrin homology domain; pfam17888"
                     /db_xref="CDD:436119"
     Region          245..273
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          <274..657
                     /region_name="RNA1"
                     /note="Ran GTPase-activating protein (RanGAP) involved in
                     mRNA processing and transport [Translation, ribosomal
                     structure and biogenesis]; COG5238"
                     /db_xref="CDD:444072"
     Region          275..303
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          304..335
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          336..365
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          366..391
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          393..420
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          425..452
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          453..479
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          480..509
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          544..570
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          571..593
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          778..1066
                     /region_name="CARMIL_C"
                     /note="CARMIL C-terminus; pfam16000"
                     /db_xref="CDD:464966"
     Region          <1132..1317
                     /region_name="PspC_subgroup_2"
                     /note="pneumococcal surface protein PspC, LPXTG-anchored
                     form; NF033839"
                     /db_xref="CDD:468202"
     CDS             1..1330
                     /gene="CARMIL3"
                     /gene_synonym="C14orf121; crml-1; LRRC16B"
                     /coded_by="XM_047431888.1:146..4138"
                     /db_xref="GeneID:90668"
                     /db_xref="HGNC:HGNC:20272"
                     /db_xref="MIM:614716"
ORIGIN      
        1 makpsveltr elqdsirrcl sqgavlqqhh vkletkpkkf edrvlaltsw rlhlfllkvp
       61 akvessfnvl eirafntlsq nqilveterg mvsmrlpsae svdqvtrhvs salskvcpgp
      121 gclirrgnad tpegprdtsp nsetststth svcggfsety aalcdynglh creevqwdvd
      181 tiyhaednre fnlldfshle srdlalmvaa laynqwftkl yckdlrlgse vleqvlhtls
      241 ksgsleelvl dnaglktdfv qklagvfgen gscvlhaltl shnpiedkgf lslsqqllcf
      301 psgltklcla ktaisprglq algqtfganp afasslryld lsknpgllat deanalysfl
      361 aqpnalvhld lsgtdcvidl llgallhgcc shltylnlar nscshrkgre appafkqffs
      421 saytlshvnl satklpleal rallqglsln shlsdlhldl sscelrsaga qalqeqlgav
      481 tcvgsldlsd ngfdsdlltl vpalgknksl khlflgknfn vkaktleeil hklvqliqee
      541 dcslqslsva dsrlklrtsi linalgsntc lakvdlsgng medigakmls kalqinsslr
      601 tilwdrnnts algfldiara lesnhtlrfm sfpvsdisqa yrsaperted vwqkiqwclv
      661 rnnhsqtcpq eqafrlqqgl vtssaeqmlq rlcgrvqeev ralrlcplep vqdellyard
      721 likdaknsra lfpslyelgh vlandgpvrq rlesvasevs kavdkelqvi lesmvsltqe
      781 lcpvamrvae ghnkmlsnva ervtvprnfi rgalleqagq diqnkldevk lsvvtyltss
      841 ivdeilqely hshkslarhl tqlrtlsdpp gcpgqgqdls srgrgrnhdh eettddelgt
      901 nidtmaikkq krcrkirpvs afisgspqdm esqlgnlgip pgwfsglggs qptasgsweg
      961 lselpthgyk lrhqtqgrpr pprttppgpg rpsmpapgtr qengmatrld egledffsrr
     1021 vleesssypr tlrtvrpgls eaplpplqkk rrrglfhfrr prsfkgdrgp gspttglllp
     1081 ppppppptqe sppspdppsl gnnsspcwsp eeessllpgf gggrgpsfrr kmgpgpdqeg
     1141 stqawqkrrs sddagpgswk pppppqstkp sfsamrraea twhiaeesap nhscqspspa
     1201 sqdgeeekeg tlfpertlpa rnaklqdpal apwppkpvav prgrqppqep gvreeaeagd
     1261 aapgvnkprl rlssqqdqee pevqgppdpg rrtaplkpkr trraqscdkl epdrrrppdp
     1321 tagtsepgtd
//
LOCUS       XP_047287845            1330 aa            linear   PRI 05-AUG-2025
DEFINITION  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X10
            [Homo sapiens].
ACCESSION   XP_047287845
VERSION     XP_047287845.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431889.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1330
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1330
                     /product="capping protein, Arp2/3 and myosin-I linker
                     protein 3 isoform X10"
                     /calculated_mol_wt=145874
     Region          31..118
                     /region_name="Carm_PH"
                     /note="Carmil pleckstrin homology domain; pfam17888"
                     /db_xref="CDD:436119"
     Region          245..273
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          <274..657
                     /region_name="RNA1"
                     /note="Ran GTPase-activating protein (RanGAP) involved in
                     mRNA processing and transport [Translation, ribosomal
                     structure and biogenesis]; COG5238"
                     /db_xref="CDD:444072"
     Region          275..303
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          304..335
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          336..365
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          366..391
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          393..420
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          425..452
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          453..479
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          480..509
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          544..570
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          571..593
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          778..1067
                     /region_name="CARMIL_C"
                     /note="CARMIL C-terminus; pfam16000"
                     /db_xref="CDD:464966"
     Region          <1133..1327
                     /region_name="PspC_subgroup_2"
                     /note="pneumococcal surface protein PspC, LPXTG-anchored
                     form; NF033839"
                     /db_xref="CDD:468202"
     CDS             1..1330
                     /gene="CARMIL3"
                     /gene_synonym="C14orf121; crml-1; LRRC16B"
                     /coded_by="XM_047431889.1:146..4138"
                     /db_xref="GeneID:90668"
                     /db_xref="HGNC:HGNC:20272"
                     /db_xref="MIM:614716"
ORIGIN      
        1 makpsveltr elqdsirrcl sqgavlqqhh vkletkpkkf edrvlaltsw rlhlfllkvp
       61 akvessfnvl eirafntlsq nqilveterg mvsmrlpsae svdqvtrhvs salskvcpgp
      121 gclirrgnad tpegprdtsp nsetststth svcggfsety aalcdynglh creevqwdvd
      181 tiyhaednre fnlldfshle srdlalmvaa laynqwftkl yckdlrlgse vleqvlhtls
      241 ksgsleelvl dnaglktdfv qklagvfgen gscvlhaltl shnpiedkgf lslsqqllcf
      301 psgltklcla ktaisprglq algqtfganp afasslryld lsknpgllat deanalysfl
      361 aqpnalvhld lsgtdcvidl llgallhgcc shltylnlar nscshrkgre appafkqffs
      421 saytlshvnl satklpleal rallqglsln shlsdlhldl sscelrsaga qalqeqlgav
      481 tcvgsldlsd ngfdsdlltl vpalgknksl khlflgknfn vkaktleeil hklvqliqee
      541 dcslqslsva dsrlklrtsi linalgsntc lakvdlsgng medigakmls kalqinsslr
      601 tilwdrnnts algfldiara lesnhtlrfm sfpvsdisqa yrsaperted vwqkiqwclv
      661 rnnhsqtcpq eqafrlqqgl vtssaeqmlq rlcgrvqeev ralrlcplep vqdellyard
      721 likdaknsra lfpslyelgh vlandgpvrq rlesvasevs kavdkelqvi lesmvsltqe
      781 lcpvamrvae ghnkmlsnva ervtvprnfi rgalleqagq diqnkldevk lsvvtyltss
      841 ivdeilqely hshkslarhl tqlrtlsdpp gcpgqgqdls srgrgrnhdh eettddelgt
      901 nidtmaikkq krcrkirpvs afisgspqdm esqlgnlgip pgwfsglggs qptasgsweg
      961 lselpthgyk lrhqtqgrpr pprttppgpg rpsqmpapgt rqengmatrl degledffsr
     1021 rvleesssyp rtlrtvrpgl seaplpplqk krrrglfhfr rprsfkgdrg pgspttglll
     1081 pppppppptq esppspdpps lgnnsspcws peeessllpg fgggrgpsfr rkmgpgpdqe
     1141 gstqawqkrr ssddagpgsw kpppppqstk psfsamrrae atwhiaeesa pnhscqspsp
     1201 asqdgeeeke gtlfpertlp arnaklqdpa lapwppkpva vprgrqppqe pgvreeaeag
     1261 daapgvnkpr lrlssqqdqe epevqgppdp grrtaplkpk rtrraqscdk lepdrrrppd
     1321 ptgtsepgtd
//
LOCUS       XP_047287846            1329 aa            linear   PRI 05-AUG-2025
DEFINITION  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X11
            [Homo sapiens].
ACCESSION   XP_047287846
VERSION     XP_047287846.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431890.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1329
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1329
                     /product="capping protein, Arp2/3 and myosin-I linker
                     protein 3 isoform X11"
                     /calculated_mol_wt=145746
     Region          31..118
                     /region_name="Carm_PH"
                     /note="Carmil pleckstrin homology domain; pfam17888"
                     /db_xref="CDD:436119"
     Region          245..273
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          <274..657
                     /region_name="RNA1"
                     /note="Ran GTPase-activating protein (RanGAP) involved in
                     mRNA processing and transport [Translation, ribosomal
                     structure and biogenesis]; COG5238"
                     /db_xref="CDD:444072"
     Region          275..303
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          304..335
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          336..365
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          366..391
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          393..420
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          425..452
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          453..479
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          480..509
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          544..570
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          571..593
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          778..1066
                     /region_name="CARMIL_C"
                     /note="CARMIL C-terminus; pfam16000"
                     /db_xref="CDD:464966"
     Region          <1106..1329
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..1329
                     /gene="CARMIL3"
                     /gene_synonym="C14orf121; crml-1; LRRC16B"
                     /coded_by="XM_047431890.1:146..4135"
                     /db_xref="GeneID:90668"
                     /db_xref="HGNC:HGNC:20272"
                     /db_xref="MIM:614716"
ORIGIN      
        1 makpsveltr elqdsirrcl sqgavlqqhh vkletkpkkf edrvlaltsw rlhlfllkvp
       61 akvessfnvl eirafntlsq nqilveterg mvsmrlpsae svdqvtrhvs salskvcpgp
      121 gclirrgnad tpegprdtsp nsetststth svcggfsety aalcdynglh creevqwdvd
      181 tiyhaednre fnlldfshle srdlalmvaa laynqwftkl yckdlrlgse vleqvlhtls
      241 ksgsleelvl dnaglktdfv qklagvfgen gscvlhaltl shnpiedkgf lslsqqllcf
      301 psgltklcla ktaisprglq algqtfganp afasslryld lsknpgllat deanalysfl
      361 aqpnalvhld lsgtdcvidl llgallhgcc shltylnlar nscshrkgre appafkqffs
      421 saytlshvnl satklpleal rallqglsln shlsdlhldl sscelrsaga qalqeqlgav
      481 tcvgsldlsd ngfdsdlltl vpalgknksl khlflgknfn vkaktleeil hklvqliqee
      541 dcslqslsva dsrlklrtsi linalgsntc lakvdlsgng medigakmls kalqinsslr
      601 tilwdrnnts algfldiara lesnhtlrfm sfpvsdisqa yrsaperted vwqkiqwclv
      661 rnnhsqtcpq eqafrlqqgl vtssaeqmlq rlcgrvqeev ralrlcplep vqdellyard
      721 likdaknsra lfpslyelgh vlandgpvrq rlesvasevs kavdkelqvi lesmvsltqe
      781 lcpvamrvae ghnkmlsnva ervtvprnfi rgalleqagq diqnkldevk lsvvtyltss
      841 ivdeilqely hshkslarhl tqlrtlsdpp gcpgqgqdls srgrgrnhdh eettddelgt
      901 nidtmaikkq krcrkirpvs afisgspqdm esqlgnlgip pgwfsglggs qptasgsweg
      961 lselpthgyk lrhqtqgrpr pprttppgpg rpsmpapgtr qengmatrld egledffsrr
     1021 vleesssypr tlrtvrpgls eaplpplqkk rrrglfhfrr prsfkgdrgp gspttglllp
     1081 ppppppptqe sppspdppsl gnnsspcwsp eeessllpgf gggrgpsfrr kmgpgpdqeg
     1141 stqawqkrrs sddagpgswk pppppqstkp sfsamrraea twhiaeesap nhscqspspa
     1201 sqdgeeekeg tlfpertlpa rnaklqdpal apwppkpvav prgrqppqep gvreeaeagd
     1261 aapgvnkprl rlssqqdqee pevqgppdpg rrtaplkpkr trraqscdkl epdrrrppdp
     1321 tgtsepgtd
//
LOCUS       XP_047287847            1328 aa            linear   PRI 05-AUG-2025
DEFINITION  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X12
            [Homo sapiens].
ACCESSION   XP_047287847
VERSION     XP_047287847.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431891.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1328
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1328
                     /product="capping protein, Arp2/3 and myosin-I linker
                     protein 3 isoform X12"
                     /calculated_mol_wt=145632
     Region          31..118
                     /region_name="Carm_PH"
                     /note="Carmil pleckstrin homology domain; pfam17888"
                     /db_xref="CDD:436119"
     Region          245..273
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          <274..657
                     /region_name="RNA1"
                     /note="Ran GTPase-activating protein (RanGAP) involved in
                     mRNA processing and transport [Translation, ribosomal
                     structure and biogenesis]; COG5238"
                     /db_xref="CDD:444072"
     Region          275..303
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          304..335
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          336..365
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          366..391
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          393..420
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          425..452
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          453..479
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          480..509
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          544..570
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          571..593
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          778..1067
                     /region_name="CARMIL_C"
                     /note="CARMIL C-terminus; pfam16000"
                     /db_xref="CDD:464966"
     Region          <1145..>1326
                     /region_name="PRK12323"
                     /note="DNA polymerase III subunit gamma/tau; cl46901"
                     /db_xref="CDD:481241"
     CDS             1..1328
                     /gene="CARMIL3"
                     /gene_synonym="C14orf121; crml-1; LRRC16B"
                     /coded_by="XM_047431891.1:146..4132"
                     /db_xref="GeneID:90668"
                     /db_xref="HGNC:HGNC:20272"
                     /db_xref="MIM:614716"
ORIGIN      
        1 makpsveltr elqdsirrcl sqgavlqqhh vkletkpkkf edrvlaltsw rlhlfllkvp
       61 akvessfnvl eirafntlsq nqilveterg mvsmrlpsae svdqvtrhvs salskvcpgp
      121 gclirrgnad tpegprdtsp nsetststth svcggfsety aalcdynglh creevqwdvd
      181 tiyhaednre fnlldfshle srdlalmvaa laynqwftkl yckdlrlgse vleqvlhtls
      241 ksgsleelvl dnaglktdfv qklagvfgen gscvlhaltl shnpiedkgf lslsqqllcf
      301 psgltklcla ktaisprglq algqtfganp afasslryld lsknpgllat deanalysfl
      361 aqpnalvhld lsgtdcvidl llgallhgcc shltylnlar nscshrkgre appafkqffs
      421 saytlshvnl satklpleal rallqglsln shlsdlhldl sscelrsaga qalqeqlgav
      481 tcvgsldlsd ngfdsdlltl vpalgknksl khlflgknfn vkaktleeil hklvqliqee
      541 dcslqslsva dsrlklrtsi linalgsntc lakvdlsgng medigakmls kalqinsslr
      601 tilwdrnnts algfldiara lesnhtlrfm sfpvsdisqa yrsaperted vwqkiqwclv
      661 rnnhsqtcpq eqafrlqqgl vtssaeqmlq rlcgrvqeev ralrlcplep vqdellyard
      721 likdaknsra lfpslyelgh vlandgpvrq rlesvasevs kavdkelqvi lesmvsltqe
      781 lcpvamrvae ghnkmlsnva ervtvprnfi rgalleqagq diqnkldevk lsvvtyltss
      841 ivdeilqely hshkslarhl tqlrtlsdpp gcpgqgqdls srgrgrnhdh eettddelgt
      901 nidtmaikkq krcrkirpvs afisgspqdm esqlgnlgip pgwfsglggs qptasgsweg
      961 lselpthgyk lrhqtqgrpr pprttppgpg rpsqmpapgt rqengmatrl degledffsr
     1021 rvleesssyp rtlrtvrpgl seaplpplqk krrrglfhfr rprsfkgdrg pgspttglll
     1081 pppppppptq esppspdpps lgnnsspcws peeessllpg fgggrgpsfr rkmgpgpdqe
     1141 gstqawqkrr ssddagpgsw kpppppqstk psfsamrrae atwhiaeesa pnhscqspsp
     1201 asqdgeeeke gtlfpertlp arnakdpala pwppkpvavp rgrqppqepg vreeaeagda
     1261 apgvnkprlr lssqqdqeep evqgppdpgr rtaplkpkrt rraqscdkle pdrrrppdpt
     1321 gtsepgtd
//
LOCUS       XP_047287848            1328 aa            linear   PRI 05-AUG-2025
DEFINITION  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X13
            [Homo sapiens].
ACCESSION   XP_047287848
VERSION     XP_047287848.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431892.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1328
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1328
                     /product="capping protein, Arp2/3 and myosin-I linker
                     protein 3 isoform X13"
                     /calculated_mol_wt=145575
     Region          31..118
                     /region_name="Carm_PH"
                     /note="Carmil pleckstrin homology domain; pfam17888"
                     /db_xref="CDD:436119"
     Region          245..273
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          <274..657
                     /region_name="RNA1"
                     /note="Ran GTPase-activating protein (RanGAP) involved in
                     mRNA processing and transport [Translation, ribosomal
                     structure and biogenesis]; COG5238"
                     /db_xref="CDD:444072"
     Region          275..303
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          304..335
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          336..365
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          366..391
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          393..420
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          425..452
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          453..479
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          480..509
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          544..570
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          571..593
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          778..1066
                     /region_name="CARMIL_C"
                     /note="CARMIL C-terminus; pfam16000"
                     /db_xref="CDD:464966"
     Region          <1144..>1325
                     /region_name="PRK12323"
                     /note="DNA polymerase III subunit gamma/tau; cl46901"
                     /db_xref="CDD:481241"
     CDS             1..1328
                     /gene="CARMIL3"
                     /gene_synonym="C14orf121; crml-1; LRRC16B"
                     /coded_by="XM_047431892.1:146..4132"
                     /db_xref="GeneID:90668"
                     /db_xref="HGNC:HGNC:20272"
                     /db_xref="MIM:614716"
ORIGIN      
        1 makpsveltr elqdsirrcl sqgavlqqhh vkletkpkkf edrvlaltsw rlhlfllkvp
       61 akvessfnvl eirafntlsq nqilveterg mvsmrlpsae svdqvtrhvs salskvcpgp
      121 gclirrgnad tpegprdtsp nsetststth svcggfsety aalcdynglh creevqwdvd
      181 tiyhaednre fnlldfshle srdlalmvaa laynqwftkl yckdlrlgse vleqvlhtls
      241 ksgsleelvl dnaglktdfv qklagvfgen gscvlhaltl shnpiedkgf lslsqqllcf
      301 psgltklcla ktaisprglq algqtfganp afasslryld lsknpgllat deanalysfl
      361 aqpnalvhld lsgtdcvidl llgallhgcc shltylnlar nscshrkgre appafkqffs
      421 saytlshvnl satklpleal rallqglsln shlsdlhldl sscelrsaga qalqeqlgav
      481 tcvgsldlsd ngfdsdlltl vpalgknksl khlflgknfn vkaktleeil hklvqliqee
      541 dcslqslsva dsrlklrtsi linalgsntc lakvdlsgng medigakmls kalqinsslr
      601 tilwdrnnts algfldiara lesnhtlrfm sfpvsdisqa yrsaperted vwqkiqwclv
      661 rnnhsqtcpq eqafrlqqgl vtssaeqmlq rlcgrvqeev ralrlcplep vqdellyard
      721 likdaknsra lfpslyelgh vlandgpvrq rlesvasevs kavdkelqvi lesmvsltqe
      781 lcpvamrvae ghnkmlsnva ervtvprnfi rgalleqagq diqnkldevk lsvvtyltss
      841 ivdeilqely hshkslarhl tqlrtlsdpp gcpgqgqdls srgrgrnhdh eettddelgt
      901 nidtmaikkq krcrkirpvs afisgspqdm esqlgnlgip pgwfsglggs qptasgsweg
      961 lselpthgyk lrhqtqgrpr pprttppgpg rpsmpapgtr qengmatrld egledffsrr
     1021 vleesssypr tlrtvrpgls eaplpplqkk rrrglfhfrr prsfkgdrgp gspttglllp
     1081 ppppppptqe sppspdppsl gnnsspcwsp eeessllpgf gggrgpsfrr kmgpgpdqeg
     1141 stqawqkrrs sddagpgswk pppppqstkp sfsamrraea twhiaeesap nhscqspspa
     1201 sqdgeeekeg tlfpertlpa rnakdpalap wppkpvavpr grqppqepgv reeaeagdaa
     1261 pgvnkprlrl ssqqdqeepe vqgppdpgrr taplkpkrtr raqscdklep drrrppdpta
     1321 gtsepgtd
//
LOCUS       XP_047287849            1327 aa            linear   PRI 05-AUG-2025
DEFINITION  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X14
            [Homo sapiens].
ACCESSION   XP_047287849
VERSION     XP_047287849.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431893.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1327
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1327
                     /product="capping protein, Arp2/3 and myosin-I linker
                     protein 3 isoform X14"
                     /calculated_mol_wt=145504
     Region          31..118
                     /region_name="Carm_PH"
                     /note="Carmil pleckstrin homology domain; pfam17888"
                     /db_xref="CDD:436119"
     Region          245..273
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          <274..657
                     /region_name="RNA1"
                     /note="Ran GTPase-activating protein (RanGAP) involved in
                     mRNA processing and transport [Translation, ribosomal
                     structure and biogenesis]; COG5238"
                     /db_xref="CDD:444072"
     Region          275..303
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          304..335
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          336..365
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          366..391
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          393..420
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          425..452
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          453..479
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          480..509
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          544..570
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          571..593
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          778..1066
                     /region_name="CARMIL_C"
                     /note="CARMIL C-terminus; pfam16000"
                     /db_xref="CDD:464966"
     Region          <1106..1327
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..1327
                     /gene="CARMIL3"
                     /gene_synonym="C14orf121; crml-1; LRRC16B"
                     /coded_by="XM_047431893.1:146..4129"
                     /db_xref="GeneID:90668"
                     /db_xref="HGNC:HGNC:20272"
                     /db_xref="MIM:614716"
ORIGIN      
        1 makpsveltr elqdsirrcl sqgavlqqhh vkletkpkkf edrvlaltsw rlhlfllkvp
       61 akvessfnvl eirafntlsq nqilveterg mvsmrlpsae svdqvtrhvs salskvcpgp
      121 gclirrgnad tpegprdtsp nsetststth svcggfsety aalcdynglh creevqwdvd
      181 tiyhaednre fnlldfshle srdlalmvaa laynqwftkl yckdlrlgse vleqvlhtls
      241 ksgsleelvl dnaglktdfv qklagvfgen gscvlhaltl shnpiedkgf lslsqqllcf
      301 psgltklcla ktaisprglq algqtfganp afasslryld lsknpgllat deanalysfl
      361 aqpnalvhld lsgtdcvidl llgallhgcc shltylnlar nscshrkgre appafkqffs
      421 saytlshvnl satklpleal rallqglsln shlsdlhldl sscelrsaga qalqeqlgav
      481 tcvgsldlsd ngfdsdlltl vpalgknksl khlflgknfn vkaktleeil hklvqliqee
      541 dcslqslsva dsrlklrtsi linalgsntc lakvdlsgng medigakmls kalqinsslr
      601 tilwdrnnts algfldiara lesnhtlrfm sfpvsdisqa yrsaperted vwqkiqwclv
      661 rnnhsqtcpq eqafrlqqgl vtssaeqmlq rlcgrvqeev ralrlcplep vqdellyard
      721 likdaknsra lfpslyelgh vlandgpvrq rlesvasevs kavdkelqvi lesmvsltqe
      781 lcpvamrvae ghnkmlsnva ervtvprnfi rgalleqagq diqnkldevk lsvvtyltss
      841 ivdeilqely hshkslarhl tqlrtlsdpp gcpgqgqdls srgrgrnhdh eettddelgt
      901 nidtmaikkq krcrkirpvs afisgspqdm esqlgnlgip pgwfsglggs qptasgsweg
      961 lselpthgyk lrhqtqgrpr pprttppgpg rpsmpapgtr qengmatrld egledffsrr
     1021 vleesssypr tlrtvrpgls eaplpplqkk rrrglfhfrr prsfkgdrgp gspttglllp
     1081 ppppppptqe sppspdppsl gnnsspcwsp eeessllpgf gggrgpsfrr kmgpgpdqeg
     1141 stqawqkrrs sddagpgswk pppppqstkp sfsamrraea twhiaeesap nhscqspspa
     1201 sqdgeeekeg tlfpertlpa rnakdpalap wppkpvavpr grqppqepgv reeaeagdaa
     1261 pgvnkprlrl ssqqdqeepe vqgppdpgrr taplkpkrtr raqscdklep drrrppdptg
     1321 tsepgtd
//
LOCUS       XP_047287850            1277 aa            linear   PRI 05-AUG-2025
DEFINITION  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X15
            [Homo sapiens].
ACCESSION   XP_047287850
VERSION     XP_047287850.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431894.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1277
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1277
                     /product="capping protein, Arp2/3 and myosin-I linker
                     protein 3 isoform X15"
                     /calculated_mol_wt=139727
     Region          148..176
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          <177..560
                     /region_name="RNA1"
                     /note="Ran GTPase-activating protein (RanGAP) involved in
                     mRNA processing and transport [Translation, ribosomal
                     structure and biogenesis]; COG5238"
                     /db_xref="CDD:444072"
     Region          178..206
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          207..238
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          239..268
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          269..294
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          296..358
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          359..382
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          383..412
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          413..438
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          447..473
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          474..493
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          681..970
                     /region_name="CARMIL_C"
                     /note="CARMIL C-terminus; pfam16000"
                     /db_xref="CDD:464966"
     Region          <1025..1241
                     /region_name="PRK07764"
                     /note="DNA polymerase III subunits gamma and tau;
                     Validated"
                     /db_xref="CDD:236090"
     CDS             1..1277
                     /gene="CARMIL3"
                     /gene_synonym="C14orf121; crml-1; LRRC16B"
                     /coded_by="XM_047431894.1:108..3941"
                     /db_xref="GeneID:90668"
                     /db_xref="HGNC:HGNC:20272"
                     /db_xref="MIM:614716"
ORIGIN      
        1 mswrsvpstr svrirswwrr svawclirrg nadtpegprd tspnsetsts tthsvcggfs
       61 etyaalcdyn glhcreevqw dvdtiyhaed nrefnlldfs hlesrdlalm vaalaynqwf
      121 tklyckdlrl gsevleqvlh tlsksgslee lvldnaglkt dfvqklagvf gengscvlha
      181 ltlshnpied kgflslsqql lcfpsgltkl claktaispr glqalgqtfg anpafasslr
      241 yldlsknpgl latdeanaly sflaqpnalv hldlsgtdcv idlllgallh gccshltyln
      301 larnscshrk greappafkq ffssaytlsh vnlsatklpl ealrallqgl slnshlsdlh
      361 ldlsscelrs agaqalqeql gavtcvgsld lsdngfdsdl ltlvpalgkn kslkhlflgk
      421 nfnvkaktle eilhklvqli qeedcslqsl svadsrlklr tsilinalgs ntclakvdls
      481 gngmedigak mlskalqins slrtilwdrn ntsalgfldi aralesnhtl rfmsfpvsdi
      541 sqayrsaper tedvwqkiqw clvrnnhsqt cpqeqafrlq qglvtssaeq mlqrlcgrvq
      601 eevralrlcp lepvqdelly ardlikdakn sralfpslye lghvlandgp vrqrlesvas
      661 evskavdkel qvilesmvsl tqelcpvamr vaeghnkmls nvaervtvpr nfirgalleq
      721 agqdiqnkld evklsvvtyl tssivdeilq elyhshksla rhltqlrtls dppgcpgqgq
      781 dlssrgrgrn hdheettdde lgtnidtmai kkqkrcrkir pvsafisgsp qdmesqlgnl
      841 gippgwfsgl ggsqptasgs weglselpth gyklrhqtqg rprpprttpp gpgrpsqmpa
      901 pgtrqengma trldegledf fsrrvleess syprtlrtvr pglseaplpp lqkkrrrglf
      961 hfrrprsfkg drgpgspttg lllppppppp ptqesppspd ppslgnnssp cwspeeessl
     1021 lpgfgggrgp sfrrkmgteg sepgeggpap gtaqqprvhg valpglerak gwsfdgkreg
     1081 pgpdqegstq awqkrrssdd agpgswkppp ppqstkpsfs amrraeatwh iaeesapnhs
     1141 cqspspasqd geeekegtlf pertlparna klqdpalapw ppkpvavprg rqppqepgvr
     1201 eeaeagdaap gvnkprlrls sqqdqeepev qgppdpgrrt aplkpkrtrr aqscdklepd
     1261 rrrppdptag tsepgtd
//
LOCUS       XP_047287851            1254 aa            linear   PRI 05-AUG-2025
DEFINITION  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X16
            [Homo sapiens].
ACCESSION   XP_047287851
VERSION     XP_047287851.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431895.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1254
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1254
                     /product="capping protein, Arp2/3 and myosin-I linker
                     protein 3 isoform X16"
                     /calculated_mol_wt=136843
     Region          125..153
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          <154..537
                     /region_name="RNA1"
                     /note="Ran GTPase-activating protein (RanGAP) involved in
                     mRNA processing and transport [Translation, ribosomal
                     structure and biogenesis]; COG5238"
                     /db_xref="CDD:444072"
     Region          155..183
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          184..215
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          216..245
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          246..271
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          273..300
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          305..332
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          333..359
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          360..389
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          424..450
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          451..473
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          658..947
                     /region_name="CARMIL_C"
                     /note="CARMIL C-terminus; pfam16000"
                     /db_xref="CDD:464966"
     Region          <1002..1218
                     /region_name="PRK07764"
                     /note="DNA polymerase III subunits gamma and tau;
                     Validated"
                     /db_xref="CDD:236090"
     CDS             1..1254
                     /gene="CARMIL3"
                     /gene_synonym="C14orf121; crml-1; LRRC16B"
                     /coded_by="XM_047431895.1:74..3838"
                     /db_xref="GeneID:90668"
                     /db_xref="HGNC:HGNC:20272"
                     /db_xref="MIM:614716"
ORIGIN      
        1 mclirrgnad tpegprdtsp nsetststth svcggfsety aalcdynglh creevqwdvd
       61 tiyhaednre fnlldfshle srdlalmvaa laynqwftkl yckdlrlgse vleqvlhtls
      121 ksgsleelvl dnaglktdfv qklagvfgen gscvlhaltl shnpiedkgf lslsqqllcf
      181 psgltklcla ktaisprglq algqtfganp afasslryld lsknpgllat deanalysfl
      241 aqpnalvhld lsgtdcvidl llgallhgcc shltylnlar nscshrkgre appafkqffs
      301 saytlshvnl satklpleal rallqglsln shlsdlhldl sscelrsaga qalqeqlgav
      361 tcvgsldlsd ngfdsdlltl vpalgknksl khlflgknfn vkaktleeil hklvqliqee
      421 dcslqslsva dsrlklrtsi linalgsntc lakvdlsgng medigakmls kalqinsslr
      481 tilwdrnnts algfldiara lesnhtlrfm sfpvsdisqa yrsaperted vwqkiqwclv
      541 rnnhsqtcpq eqafrlqqgl vtssaeqmlq rlcgrvqeev ralrlcplep vqdellyard
      601 likdaknsra lfpslyelgh vlandgpvrq rlesvasevs kavdkelqvi lesmvsltqe
      661 lcpvamrvae ghnkmlsnva ervtvprnfi rgalleqagq diqnkldevk lsvvtyltss
      721 ivdeilqely hshkslarhl tqlrtlsdpp gcpgqgqdls srgrgrnhdh eettddelgt
      781 nidtmaikkq krcrkirpvs afisgspqdm esqlgnlgip pgwfsglggs qptasgsweg
      841 lselpthgyk lrhqtqgrpr pprttppgpg rpsqmpapgt rqengmatrl degledffsr
      901 rvleesssyp rtlrtvrpgl seaplpplqk krrrglfhfr rprsfkgdrg pgspttglll
      961 pppppppptq esppspdpps lgnnsspcws peeessllpg fgggrgpsfr rkmgtegsep
     1021 geggpapgta qqprvhgval pglerakgws fdgkregpgp dqegstqawq krrssddagp
     1081 gswkpppppq stkpsfsamr raeatwhiae esapnhscqs pspasqdgee ekegtlfper
     1141 tlparnaklq dpalapwppk pvavprgrqp pqepgvreea eagdaapgvn kprlrlssqq
     1201 dqeepevqgp pdpgrrtapl kpkrtrraqs cdklepdrrr ppdptagtse pgtd
//
LOCUS       XP_047287852            1079 aa            linear   PRI 05-AUG-2025
DEFINITION  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X17
            [Homo sapiens].
ACCESSION   XP_047287852
VERSION     XP_047287852.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431896.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1079
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1079
                     /product="capping protein, Arp2/3 and myosin-I linker
                     protein 3 isoform X17"
                     /calculated_mol_wt=118645
     Region          31..118
                     /region_name="Carm_PH"
                     /note="Carmil pleckstrin homology domain; pfam17888"
                     /db_xref="CDD:436119"
     Region          245..273
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          <274..657
                     /region_name="RNA1"
                     /note="Ran GTPase-activating protein (RanGAP) involved in
                     mRNA processing and transport [Translation, ribosomal
                     structure and biogenesis]; COG5238"
                     /db_xref="CDD:444072"
     Region          275..303
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          304..335
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          336..365
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          366..391
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          393..420
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          425..452
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          453..479
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          480..509
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          778..1045
                     /region_name="CARMIL_C"
                     /note="CARMIL C-terminus; pfam16000"
                     /db_xref="CDD:464966"
     CDS             1..1079
                     /gene="CARMIL3"
                     /gene_synonym="C14orf121; crml-1; LRRC16B"
                     /coded_by="XM_047431896.1:146..3385"
                     /db_xref="GeneID:90668"
                     /db_xref="HGNC:HGNC:20272"
                     /db_xref="MIM:614716"
ORIGIN      
        1 makpsveltr elqdsirrcl sqgavlqqhh vkletkpkkf edrvlaltsw rlhlfllkvp
       61 akvessfnvl eirafntlsq nqilveterg mvsmrlpsae svdqvtrhvs salskvcpgp
      121 gclirrgnad tpegprdtsp nsetststth svcggfsety aalcdynglh creevqwdvd
      181 tiyhaednre fnlldfshle srdlalmvaa laynqwftkl yckdlrlgse vleqvlhtls
      241 ksgsleelvl dnaglktdfv qklagvfgen gscvlhaltl shnpiedkgf lslsqqllcf
      301 psgltklcla ktaisprglq algqtfganp afasslryld lsknpgllat deanalysfl
      361 aqpnalvhld lsgtdcvidl llgallhgcc shltylnlar nscshrkgre appafkqffs
      421 saytlshvnl satklpleal rallqglsln shlsdlhldl sscelrsaga qalqeqlgav
      481 tcvgsldlsd ngfdsdlltl vpalgknksl khlflgknfn vkaktleeil hklvqliqee
      541 dcslqslsva dsrlklrtsi linalgsntc lakvdlsgng medigakmls kalqinsslr
      601 tilwdrnnts algfldiara lesnhtlrfm sfpvsdisqa yrsaperted vwqkiqwclv
      661 rnnhsqtcpq eqafrlqqgl vtssaeqmlq rlcgrvqeev ralrlcplep vqdellyard
      721 likdaknsra lfpslyelgh vlandgpvrq rlesvasevs kavdkelqvi lesmvsltqe
      781 lcpvamrvae ghnkmlsnva ervtvprnfi rgalleqagq diqnkldevk lsvvtyltss
      841 ivdeilqely hshkslarhl tqlrtlsdpp gcpgqgqdls srgrgrnhdh eettddelgt
      901 nidtmaikkq krcrkirpvs afisgspqdm esqlgnlgip pgwfsglggs qptasgsweg
      961 lselpthgyk lrhqtqgrpr pprttppgpg rpsqmpapgt rqengmatrl degledffsr
     1021 rvleessrlp rvcpggarsl geaerscrgg aweetsvcgk gcwrittgqe rqghhlpen
//
LOCUS       XP_024305507             238 aa            linear   PRI 05-AUG-2025
DEFINITION  type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform
            X1 [Homo sapiens].
ACCESSION   XP_024305507
VERSION     XP_024305507.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449739.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..238
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..238
                     /product="type 1 phosphatidylinositol 4,5-bisphosphate
                     4-phosphatase isoform X1"
                     /calculated_mol_wt=24328
     Region          4..>154
                     /region_name="Tmemb_55A"
                     /note="Transmembrane protein 55A; pfam09788"
                     /db_xref="CDD:462901"
     CDS             1..238
                     /gene="PIP4P1"
                     /gene_synonym="C14orf9; TMEM55B"
                     /coded_by="XM_024449739.2:110..826"
                     /db_xref="GeneID:90809"
                     /db_xref="HGNC:HGNC:19299"
                     /db_xref="MIM:609865"
ORIGIN      
        1 maadgerspl lsepidggag gnglvgpggs gagpgggltp sappygagkh appqafppfp
       61 eghpavlpge dpppysplts pdsgsapmit crvcqslinv egkmhqhvvk cgvcneatpi
      121 knappgkkyv rcpcncllic kvtsqriacp rpycgqssqt alwhvvltag kchllgadth
      181 vrdvsaascl acfwqslpla lplahgsmhg dmeasmqpgh lsscwlccvw aglfigpv
//
LOCUS       XP_024305508             231 aa            linear   PRI 05-AUG-2025
DEFINITION  type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform
            X2 [Homo sapiens].
ACCESSION   XP_024305508
VERSION     XP_024305508.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449740.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..231
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..231
                     /product="type 1 phosphatidylinositol 4,5-bisphosphate
                     4-phosphatase isoform X2"
                     /calculated_mol_wt=23612
     Region          4..>147
                     /region_name="Tmemb_55A"
                     /note="Transmembrane protein 55A; pfam09788"
                     /db_xref="CDD:462901"
     CDS             1..231
                     /gene="PIP4P1"
                     /gene_synonym="C14orf9; TMEM55B"
                     /coded_by="XM_024449740.2:110..805"
                     /db_xref="GeneID:90809"
                     /db_xref="HGNC:HGNC:19299"
                     /db_xref="MIM:609865"
ORIGIN      
        1 maadgerspl lsepidggag gnglvgpggs gagpgggltp sappygaafp pfpeghpavl
       61 pgedpppysp ltspdsgsap mitcrvcqsl invegkmhqh vvkcgvcnea tpiknappgk
      121 kyvrcpcncl lickvtsqri acprpycgqs sqtalwhvvl tagkchllga dthvrdvsaa
      181 sclacfwqsl plalplahgs mhgdmeasmq pghlsscwlc cvwaglfigp v
//
LOCUS       XP_047287854             748 aa            linear   PRI 05-AUG-2025
DEFINITION  metastasis-associated protein MTA1 isoform X1 [Homo sapiens].
ACCESSION   XP_047287854
VERSION     XP_047287854.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431898.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..748
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..748
                     /product="metastasis-associated protein MTA1 isoform X1"
                     /calculated_mol_wt=83940
     Region          50..217
                     /region_name="BAH_MTA"
                     /note="BAH, or Bromo Adjacent Homology domain, as present
                     in MTA1 and similar proteins. The Metastasis-associated
                     protein MTA1 is part of the NURD (nucleosome remodeling
                     and deacetylating) complex and plays a role in cellular
                     transformation and metastasis. BAH...; cd04709"
                     /db_xref="CDD:240060"
     Region          196..248
                     /region_name="ELM2"
                     /note="ELM2 domain; pfam01448"
                     /db_xref="CDD:460214"
     Region          316..361
                     /region_name="SANT_MTA3_like"
                     /note="Myb-Like Dna-Binding Domain of MTA3 and related
                     proteins; cd11661"
                     /db_xref="CDD:212559"
     Site            order(317,347..348,350..351,353..355,357..359)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212559"
     Region          417..470
                     /region_name="ZnF_GATA"
                     /note="zinc finger binding to DNA consensus sequence
                     [AT]GATA[AG]; smart00401"
                     /db_xref="CDD:214648"
     Region          493..570
                     /region_name="MTA_R1"
                     /note="MTA R1 domain; pfam17226"
                     /db_xref="CDD:465388"
     CDS             1..748
                     /gene="MTA1"
                     /coded_by="XM_047431898.1:210..2456"
                     /db_xref="GeneID:9112"
                     /db_xref="HGNC:HGNC:7410"
                     /db_xref="MIM:603526"
ORIGIN      
        1 mawalaclwa ghqpvrgttt lldcsgraae pdahhveknp qacdrvrpvp stprssrrgf
       61 qtangnveak vvcfyrrrdi sstlialadk hatlsvcyka gpgadngeeg eieeemenpe
      121 mvdlpeklkh qlrhrelfls rqleslpath irgkcsvtll neteslksyl eredfffysl
      181 vydpqqktll adkgeirvgn ryqaditdll kegeedgrdq srletqvwea hnpltdkqid
      241 qflvvarsvg tfaraldcss svrqpslhms aaaasrditl fhamdtlhkn iydiskaisa
      301 lvpqggpvlc rdemeewsas eanlfeeale kygkdftdiq qdflpwkslt siieyyymwk
      361 ttdryvqqkr lkaaeaeskl kqvyipnynk pnpnqisvnn vkagvvngtg apgqspgagr
      421 acescyttqs yqwyswgppn mqcrlcascw tywkkygglk mptrldgerp gpnrsnmsph
      481 glparssgsp kfamktrqaf ylhttkltri arrlcreilr pwhaarhpyl pinsaaikae
      541 ctarlpeasq splvlkqavr kpleavlryl ethprppkpd pvksvssvls sltpakvapv
      601 inngsptilg krsyeqhngv dgnmkkrllm psrgtylgla nhgqarhmgp srnlllngks
      661 yptkvrlirg gslppvkrrr mnwidapddv fymateetrk irkllssset kraarrpykp
      721 ialrqsqalp prppppapvn depivied
//
LOCUS       XP_047287855             744 aa            linear   PRI 05-AUG-2025
DEFINITION  metastasis-associated protein MTA1 isoform X2 [Homo sapiens].
ACCESSION   XP_047287855
VERSION     XP_047287855.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431899.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..744
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..744
                     /product="metastasis-associated protein MTA1 isoform X2"
                     /calculated_mol_wt=83506
     Region          50..217
                     /region_name="BAH_MTA"
                     /note="BAH, or Bromo Adjacent Homology domain, as present
                     in MTA1 and similar proteins. The Metastasis-associated
                     protein MTA1 is part of the NURD (nucleosome remodeling
                     and deacetylating) complex and plays a role in cellular
                     transformation and metastasis. BAH...; cd04709"
                     /db_xref="CDD:240060"
     Region          196..248
                     /region_name="ELM2"
                     /note="ELM2 domain; pfam01448"
                     /db_xref="CDD:460214"
     Region          316..361
                     /region_name="SANT_MTA3_like"
                     /note="Myb-Like Dna-Binding Domain of MTA3 and related
                     proteins; cd11661"
                     /db_xref="CDD:212559"
     Site            order(317,347..348,350..351,353..355,357..359)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212559"
     Region          417..470
                     /region_name="ZnF_GATA"
                     /note="zinc finger binding to DNA consensus sequence
                     [AT]GATA[AG]; smart00401"
                     /db_xref="CDD:214648"
     Region          493..570
                     /region_name="MTA_R1"
                     /note="MTA R1 domain; pfam17226"
                     /db_xref="CDD:465388"
     CDS             1..744
                     /gene="MTA1"
                     /coded_by="XM_047431899.1:206..2440"
                     /db_xref="GeneID:9112"
                     /db_xref="HGNC:HGNC:7410"
                     /db_xref="MIM:603526"
ORIGIN      
        1 mawalaclwa ghqpvrgttt lldcsgraae pdahhveknp qacdrvrpvp stprssrrgf
       61 qtangnveak vvcfyrrrdi sstlialadk hatlsvcyka gpgadngeeg eieeemenpe
      121 mvdlpeklkh qlrhrelfls rqleslpath irgkcsvtll neteslksyl eredfffysl
      181 vydpqqktll adkgeirvgn ryqaditdll kegeedgrdq srletqvwea hnpltdkqid
      241 qflvvarsvg tfaraldcss svrqpslhms aaaasrditl fhamdtlhkn iydiskaisa
      301 lvpqggpvlc rdemeewsas eanlfeeale kygkdftdiq qdflpwkslt siieyyymwk
      361 ttdryvqqkr lkaaeaeskl kqvyipnynk pnpnqisvnn vkagvvngtg apgqspgagr
      421 acescyttqs yqwyswgppn mqcrlcascw tywkkygglk mptrldgerp gpnrsnmsph
      481 glparssgsp kfamktrqaf ylhttkltri arrlcreilr pwhaarhpyl pinsaaikae
      541 ctarlpeasq splvlkqavr kpleavlryl ethprppkpd pvksvssvls sltpakvapv
      601 inngsptilg krsyeqhngv dgnmkkrllm psrglanhgq arhmgpsrnl llngksyptk
      661 vrlirggslp pvkrrrmnwi dapddvfyma teetrkirkl lsssetkraa rrpykpialr
      721 qsqalpprpp ppapvndepi vied
//
LOCUS       XP_047287856             732 aa            linear   PRI 05-AUG-2025
DEFINITION  metastasis-associated protein MTA1 isoform X3 [Homo sapiens].
ACCESSION   XP_047287856
VERSION     XP_047287856.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431900.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..732
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..732
                     /product="metastasis-associated protein MTA1 isoform X3"
                     /calculated_mol_wt=82093
     Region          50..217
                     /region_name="BAH_MTA"
                     /note="BAH, or Bromo Adjacent Homology domain, as present
                     in MTA1 and similar proteins. The Metastasis-associated
                     protein MTA1 is part of the NURD (nucleosome remodeling
                     and deacetylating) complex and plays a role in cellular
                     transformation and metastasis. BAH...; cd04709"
                     /db_xref="CDD:240060"
     Region          196..248
                     /region_name="ELM2"
                     /note="ELM2 domain; pfam01448"
                     /db_xref="CDD:460214"
     Region          316..361
                     /region_name="SANT_MTA3_like"
                     /note="Myb-Like Dna-Binding Domain of MTA3 and related
                     proteins; cd11661"
                     /db_xref="CDD:212559"
     Site            order(317,347..348,350..351,353..355,357..359)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212559"
     Region          417..470
                     /region_name="ZnF_GATA"
                     /note="zinc finger binding to DNA consensus sequence
                     [AT]GATA[AG]; smart00401"
                     /db_xref="CDD:214648"
     Region          493..570
                     /region_name="MTA_R1"
                     /note="MTA R1 domain; pfam17226"
                     /db_xref="CDD:465388"
     CDS             1..732
                     /gene="MTA1"
                     /coded_by="XM_047431900.1:208..2406"
                     /db_xref="GeneID:9112"
                     /db_xref="HGNC:HGNC:7410"
                     /db_xref="MIM:603526"
ORIGIN      
        1 mawalaclwa ghqpvrgttt lldcsgraae pdahhveknp qacdrvrpvp stprssrrgf
       61 qtangnveak vvcfyrrrdi sstlialadk hatlsvcyka gpgadngeeg eieeemenpe
      121 mvdlpeklkh qlrhrelfls rqleslpath irgkcsvtll neteslksyl eredfffysl
      181 vydpqqktll adkgeirvgn ryqaditdll kegeedgrdq srletqvwea hnpltdkqid
      241 qflvvarsvg tfaraldcss svrqpslhms aaaasrditl fhamdtlhkn iydiskaisa
      301 lvpqggpvlc rdemeewsas eanlfeeale kygkdftdiq qdflpwkslt siieyyymwk
      361 ttdryvqqkr lkaaeaeskl kqvyipnynk pnpnqisvnn vkagvvngtg apgqspgagr
      421 acescyttqs yqwyswgppn mqcrlcascw tywkkygglk mptrldgerp gpnrsnmsph
      481 glparssgsp kfamktrqaf ylhttkltri arrlcreilr pwhaarhpyl pinsaaikae
      541 ctarlpeasq splvlkqavr kpleavlryl ethprppkpd pvksvssvls sltpakvapv
      601 inngsptilg krsyeqhngv dglanhgqar hmgpsrnlll ngksyptkvr lirggslppv
      661 krrrmnwida pddvfymate etrkirklls ssetkraarr pykpialrqs qalpprpppp
      721 apvndepivi ed
//
LOCUS       XP_047287857             731 aa            linear   PRI 05-AUG-2025
DEFINITION  metastasis-associated protein MTA1 isoform X4 [Homo sapiens].
ACCESSION   XP_047287857
VERSION     XP_047287857.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431901.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..731
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..731
                     /product="metastasis-associated protein MTA1 isoform X4"
                     /calculated_mol_wt=82346
     Region          50..200
                     /region_name="BAH_MTA"
                     /note="BAH, or Bromo Adjacent Homology domain, as present
                     in MTA1 and similar proteins. The Metastasis-associated
                     protein MTA1 is part of the NURD (nucleosome remodeling
                     and deacetylating) complex and plays a role in cellular
                     transformation and metastasis. BAH...; cd04709"
                     /db_xref="CDD:240060"
     Region          179..231
                     /region_name="ELM2"
                     /note="ELM2 domain; pfam01448"
                     /db_xref="CDD:460214"
     Region          299..344
                     /region_name="SANT_MTA3_like"
                     /note="Myb-Like Dna-Binding Domain of MTA3 and related
                     proteins; cd11661"
                     /db_xref="CDD:212559"
     Site            order(300,330..331,333..334,336..338,340..342)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212559"
     Region          400..453
                     /region_name="ZnF_GATA"
                     /note="zinc finger binding to DNA consensus sequence
                     [AT]GATA[AG]; smart00401"
                     /db_xref="CDD:214648"
     Region          476..553
                     /region_name="MTA_R1"
                     /note="MTA R1 domain; pfam17226"
                     /db_xref="CDD:465388"
     CDS             1..731
                     /gene="MTA1"
                     /coded_by="XM_047431901.1:214..2409"
                     /db_xref="GeneID:9112"
                     /db_xref="HGNC:HGNC:7410"
                     /db_xref="MIM:603526"
ORIGIN      
        1 mawalaclwa ghqpvrgttt lldcsgraae pdahhveknp qacdrvrpvp stprssrrgf
       61 qtangnveak vvcfyrrrdi sstlialadk hareieeeme npemvdlpek lkhqlrhrel
      121 flsrqleslp athirgkcsv tllneteslk syleredfff yslvydpqqk tlladkgeir
      181 vgnryqadit dllkegeedg rdqsrletqv weahnpltdk qidqflvvar svgtfarald
      241 csssvrqpsl hmsaaaasrd itlfhamdtl hkniydiska isalvpqggp vlcrdemeew
      301 saseanlfee alekygkdft diqqdflpwk sltsiieyyy mwkttdryvq qkrlkaaeae
      361 sklkqvyipn ynkpnpnqis vnnvkagvvn gtgapgqspg agracescyt tqsyqwyswg
      421 ppnmqcrlca scwtywkkyg glkmptrldg erpgpnrsnm sphglparss gspkfamktr
      481 qafylhttkl triarrlcre ilrpwhaarh pylpinsaai kaectarlpe asqsplvlkq
      541 avrkpleavl rylethprpp kpdpvksvss vlssltpakv apvinngspt ilgkrsyeqh
      601 ngvdgnmkkr llmpsrgtyl glanhgqarh mgpsrnllln gksyptkvrl irggslppvk
      661 rrrmnwidap ddvfymatee trkirkllss setkraarrp ykpialrqsq alpprppppa
      721 pvndepivie d
//
LOCUS       XP_047287858             727 aa            linear   PRI 05-AUG-2025
DEFINITION  metastasis-associated protein MTA1 isoform X5 [Homo sapiens].
ACCESSION   XP_047287858
VERSION     XP_047287858.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431902.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..727
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..727
                     /product="metastasis-associated protein MTA1 isoform X5"
                     /calculated_mol_wt=81912
     Region          50..200
                     /region_name="BAH_MTA"
                     /note="BAH, or Bromo Adjacent Homology domain, as present
                     in MTA1 and similar proteins. The Metastasis-associated
                     protein MTA1 is part of the NURD (nucleosome remodeling
                     and deacetylating) complex and plays a role in cellular
                     transformation and metastasis. BAH...; cd04709"
                     /db_xref="CDD:240060"
     Region          179..231
                     /region_name="ELM2"
                     /note="ELM2 domain; pfam01448"
                     /db_xref="CDD:460214"
     Region          299..344
                     /region_name="SANT_MTA3_like"
                     /note="Myb-Like Dna-Binding Domain of MTA3 and related
                     proteins; cd11661"
                     /db_xref="CDD:212559"
     Site            order(300,330..331,333..334,336..338,340..342)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212559"
     Region          400..453
                     /region_name="ZnF_GATA"
                     /note="zinc finger binding to DNA consensus sequence
                     [AT]GATA[AG]; smart00401"
                     /db_xref="CDD:214648"
     Region          476..553
                     /region_name="MTA_R1"
                     /note="MTA R1 domain; pfam17226"
                     /db_xref="CDD:465388"
     CDS             1..727
                     /gene="MTA1"
                     /coded_by="XM_047431902.1:208..2391"
                     /db_xref="GeneID:9112"
                     /db_xref="HGNC:HGNC:7410"
                     /db_xref="MIM:603526"
ORIGIN      
        1 mawalaclwa ghqpvrgttt lldcsgraae pdahhveknp qacdrvrpvp stprssrrgf
       61 qtangnveak vvcfyrrrdi sstlialadk hareieeeme npemvdlpek lkhqlrhrel
      121 flsrqleslp athirgkcsv tllneteslk syleredfff yslvydpqqk tlladkgeir
      181 vgnryqadit dllkegeedg rdqsrletqv weahnpltdk qidqflvvar svgtfarald
      241 csssvrqpsl hmsaaaasrd itlfhamdtl hkniydiska isalvpqggp vlcrdemeew
      301 saseanlfee alekygkdft diqqdflpwk sltsiieyyy mwkttdryvq qkrlkaaeae
      361 sklkqvyipn ynkpnpnqis vnnvkagvvn gtgapgqspg agracescyt tqsyqwyswg
      421 ppnmqcrlca scwtywkkyg glkmptrldg erpgpnrsnm sphglparss gspkfamktr
      481 qafylhttkl triarrlcre ilrpwhaarh pylpinsaai kaectarlpe asqsplvlkq
      541 avrkpleavl rylethprpp kpdpvksvss vlssltpakv apvinngspt ilgkrsyeqh
      601 ngvdgnmkkr llmpsrglan hgqarhmgps rnlllngksy ptkvrlirgg slppvkrrrm
      661 nwidapddvf ymateetrki rkllsssetk raarrpykpi alrqsqalpp rppppapvnd
      721 epivied
//
LOCUS       XP_047287859             715 aa            linear   PRI 05-AUG-2025
DEFINITION  metastasis-associated protein MTA1 isoform X6 [Homo sapiens].
ACCESSION   XP_047287859
VERSION     XP_047287859.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431903.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..715
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..715
                     /product="metastasis-associated protein MTA1 isoform X6"
                     /calculated_mol_wt=80499
     Region          50..200
                     /region_name="BAH_MTA"
                     /note="BAH, or Bromo Adjacent Homology domain, as present
                     in MTA1 and similar proteins. The Metastasis-associated
                     protein MTA1 is part of the NURD (nucleosome remodeling
                     and deacetylating) complex and plays a role in cellular
                     transformation and metastasis. BAH...; cd04709"
                     /db_xref="CDD:240060"
     Region          179..231
                     /region_name="ELM2"
                     /note="ELM2 domain; pfam01448"
                     /db_xref="CDD:460214"
     Region          299..344
                     /region_name="SANT_MTA3_like"
                     /note="Myb-Like Dna-Binding Domain of MTA3 and related
                     proteins; cd11661"
                     /db_xref="CDD:212559"
     Site            order(300,330..331,333..334,336..338,340..342)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212559"
     Region          400..453
                     /region_name="ZnF_GATA"
                     /note="zinc finger binding to DNA consensus sequence
                     [AT]GATA[AG]; smart00401"
                     /db_xref="CDD:214648"
     Region          476..553
                     /region_name="MTA_R1"
                     /note="MTA R1 domain; pfam17226"
                     /db_xref="CDD:465388"
     CDS             1..715
                     /gene="MTA1"
                     /coded_by="XM_047431903.1:211..2358"
                     /db_xref="GeneID:9112"
                     /db_xref="HGNC:HGNC:7410"
                     /db_xref="MIM:603526"
ORIGIN      
        1 mawalaclwa ghqpvrgttt lldcsgraae pdahhveknp qacdrvrpvp stprssrrgf
       61 qtangnveak vvcfyrrrdi sstlialadk hareieeeme npemvdlpek lkhqlrhrel
      121 flsrqleslp athirgkcsv tllneteslk syleredfff yslvydpqqk tlladkgeir
      181 vgnryqadit dllkegeedg rdqsrletqv weahnpltdk qidqflvvar svgtfarald
      241 csssvrqpsl hmsaaaasrd itlfhamdtl hkniydiska isalvpqggp vlcrdemeew
      301 saseanlfee alekygkdft diqqdflpwk sltsiieyyy mwkttdryvq qkrlkaaeae
      361 sklkqvyipn ynkpnpnqis vnnvkagvvn gtgapgqspg agracescyt tqsyqwyswg
      421 ppnmqcrlca scwtywkkyg glkmptrldg erpgpnrsnm sphglparss gspkfamktr
      481 qafylhttkl triarrlcre ilrpwhaarh pylpinsaai kaectarlpe asqsplvlkq
      541 avrkpleavl rylethprpp kpdpvksvss vlssltpakv apvinngspt ilgkrsyeqh
      601 ngvdglanhg qarhmgpsrn lllngksypt kvrlirggsl ppvkrrrmnw idapddvfym
      661 ateetrkirk llsssetkra arrpykpial rqsqalpprp pppapvndep ivied
//
LOCUS       XP_011535607             775 aa            linear   PRI 05-AUG-2025
DEFINITION  metastasis-associated protein MTA1 isoform X7 [Homo sapiens].
ACCESSION   XP_011535607
VERSION     XP_011535607.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537305.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..775
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..775
                     /product="metastasis-associated protein MTA1 isoform X7"
                     /calculated_mol_wt=87090
     Region          64..244
                     /region_name="BAH_MTA"
                     /note="BAH, or Bromo Adjacent Homology domain, as present
                     in MTA1 and similar proteins. The Metastasis-associated
                     protein MTA1 is part of the NURD (nucleosome remodeling
                     and deacetylating) complex and plays a role in cellular
                     transformation and metastasis. BAH...; cd04709"
                     /db_xref="CDD:240060"
     Region          223..275
                     /region_name="ELM2"
                     /note="ELM2 domain; pfam01448"
                     /db_xref="CDD:460214"
     Region          343..388
                     /region_name="SANT_MTA3_like"
                     /note="Myb-Like Dna-Binding Domain of MTA3 and related
                     proteins; cd11661"
                     /db_xref="CDD:212559"
     Site            order(344,374..375,377..378,380..382,384..386)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212559"
     Region          444..497
                     /region_name="ZnF_GATA"
                     /note="zinc finger binding to DNA consensus sequence
                     [AT]GATA[AG]; smart00401"
                     /db_xref="CDD:214648"
     Region          520..597
                     /region_name="MTA_R1"
                     /note="MTA R1 domain; pfam17226"
                     /db_xref="CDD:465388"
     CDS             1..775
                     /gene="MTA1"
                     /coded_by="XM_011537305.1:16..2343"
                     /db_xref="GeneID:9112"
                     /db_xref="HGNC:HGNC:7410"
                     /db_xref="MIM:603526"
ORIGIN      
        1 mpgrdaaglf scdeehgrlg avcwqhshaw dpdcfcvcsp wslwpgvlga vrpptcpprg
       61 lplpadyvyf ensssnpyli rrieelnkta ngnveakvvc fyrrrdisst lialadkhat
      121 lsvcykagpg adngeegeie eemenpemvd lpeklkhqlr hrelflsrql eslpathirg
      181 kcsvtllnet eslksylere dfffyslvyd pqqktlladk geirvgnryq aditdllkeg
      241 eedgrdqsrl etqvweahnp ltdkqidqfl vvarsvgtfa raldcsssvr qpslhmsaaa
      301 asrditlfha mdtlhkniyd iskaisalvp qggpvlcrde meewsasean lfeealekyg
      361 kdftdiqqdf lpwksltsii eyyymwkttd ryvqqkrlka aeaesklkqv yipnynkpnp
      421 nqisvnnvka gvvngtgapg qspgagrace scyttqsyqw yswgppnmqc rlcascwtyw
      481 kkygglkmpt rldgerpgpn rsnmsphglp arssgspkfa mktrqafylh ttkltriarr
      541 lcreilrpwh aarhpylpin saaikaecta rlpeasqspl vlkqavrkpl eavlryleth
      601 prppkpdpvk svssvlsslt pakvapvinn gsptilgkrs yeqhngvdgn mkkrllmpsr
      661 gtylglanhg qarhmgpsrn lllngksypt kvrlirggsl ppvkrrrmnw idapddvfym
      721 ateetrkirk llsssetkra arrpykpial rqsqalpprp pppapvndep ivied
//
LOCUS       XP_011535608             771 aa            linear   PRI 05-AUG-2025
DEFINITION  metastasis-associated protein MTA1 isoform X8 [Homo sapiens].
ACCESSION   XP_011535608
VERSION     XP_011535608.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537306.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..771
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..771
                     /product="metastasis-associated protein MTA1 isoform X8"
                     /calculated_mol_wt=86655
     Region          64..244
                     /region_name="BAH_MTA"
                     /note="BAH, or Bromo Adjacent Homology domain, as present
                     in MTA1 and similar proteins. The Metastasis-associated
                     protein MTA1 is part of the NURD (nucleosome remodeling
                     and deacetylating) complex and plays a role in cellular
                     transformation and metastasis. BAH...; cd04709"
                     /db_xref="CDD:240060"
     Region          223..275
                     /region_name="ELM2"
                     /note="ELM2 domain; pfam01448"
                     /db_xref="CDD:460214"
     Region          343..388
                     /region_name="SANT_MTA3_like"
                     /note="Myb-Like Dna-Binding Domain of MTA3 and related
                     proteins; cd11661"
                     /db_xref="CDD:212559"
     Site            order(344,374..375,377..378,380..382,384..386)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212559"
     Region          444..497
                     /region_name="ZnF_GATA"
                     /note="zinc finger binding to DNA consensus sequence
                     [AT]GATA[AG]; smart00401"
                     /db_xref="CDD:214648"
     Region          520..597
                     /region_name="MTA_R1"
                     /note="MTA R1 domain; pfam17226"
                     /db_xref="CDD:465388"
     CDS             1..771
                     /gene="MTA1"
                     /coded_by="XM_011537306.1:16..2331"
                     /db_xref="GeneID:9112"
                     /db_xref="HGNC:HGNC:7410"
                     /db_xref="MIM:603526"
ORIGIN      
        1 mpgrdaaglf scdeehgrlg avcwqhshaw dpdcfcvcsp wslwpgvlga vrpptcpprg
       61 lplpadyvyf ensssnpyli rrieelnkta ngnveakvvc fyrrrdisst lialadkhat
      121 lsvcykagpg adngeegeie eemenpemvd lpeklkhqlr hrelflsrql eslpathirg
      181 kcsvtllnet eslksylere dfffyslvyd pqqktlladk geirvgnryq aditdllkeg
      241 eedgrdqsrl etqvweahnp ltdkqidqfl vvarsvgtfa raldcsssvr qpslhmsaaa
      301 asrditlfha mdtlhkniyd iskaisalvp qggpvlcrde meewsasean lfeealekyg
      361 kdftdiqqdf lpwksltsii eyyymwkttd ryvqqkrlka aeaesklkqv yipnynkpnp
      421 nqisvnnvka gvvngtgapg qspgagrace scyttqsyqw yswgppnmqc rlcascwtyw
      481 kkygglkmpt rldgerpgpn rsnmsphglp arssgspkfa mktrqafylh ttkltriarr
      541 lcreilrpwh aarhpylpin saaikaecta rlpeasqspl vlkqavrkpl eavlryleth
      601 prppkpdpvk svssvlsslt pakvapvinn gsptilgkrs yeqhngvdgn mkkrllmpsr
      661 glanhgqarh mgpsrnllln gksyptkvrl irggslppvk rrrmnwidap ddvfymatee
      721 trkirkllss setkraarrp ykpialrqsq alpprppppa pvndepivie d
//
LOCUS       XP_011535609             759 aa            linear   PRI 05-AUG-2025
DEFINITION  metastasis-associated protein MTA1 isoform X9 [Homo sapiens].
ACCESSION   XP_011535609
VERSION     XP_011535609.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537307.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..759
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..759
                     /product="metastasis-associated protein MTA1 isoform X9"
                     /calculated_mol_wt=85242
     Region          64..244
                     /region_name="BAH_MTA"
                     /note="BAH, or Bromo Adjacent Homology domain, as present
                     in MTA1 and similar proteins. The Metastasis-associated
                     protein MTA1 is part of the NURD (nucleosome remodeling
                     and deacetylating) complex and plays a role in cellular
                     transformation and metastasis. BAH...; cd04709"
                     /db_xref="CDD:240060"
     Region          223..275
                     /region_name="ELM2"
                     /note="ELM2 domain; pfam01448"
                     /db_xref="CDD:460214"
     Region          343..388
                     /region_name="SANT_MTA3_like"
                     /note="Myb-Like Dna-Binding Domain of MTA3 and related
                     proteins; cd11661"
                     /db_xref="CDD:212559"
     Site            order(344,374..375,377..378,380..382,384..386)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212559"
     Region          444..497
                     /region_name="ZnF_GATA"
                     /note="zinc finger binding to DNA consensus sequence
                     [AT]GATA[AG]; smart00401"
                     /db_xref="CDD:214648"
     Region          520..597
                     /region_name="MTA_R1"
                     /note="MTA R1 domain; pfam17226"
                     /db_xref="CDD:465388"
     CDS             1..759
                     /gene="MTA1"
                     /coded_by="XM_011537307.1:16..2295"
                     /db_xref="GeneID:9112"
                     /db_xref="HGNC:HGNC:7410"
                     /db_xref="MIM:603526"
ORIGIN      
        1 mpgrdaaglf scdeehgrlg avcwqhshaw dpdcfcvcsp wslwpgvlga vrpptcpprg
       61 lplpadyvyf ensssnpyli rrieelnkta ngnveakvvc fyrrrdisst lialadkhat
      121 lsvcykagpg adngeegeie eemenpemvd lpeklkhqlr hrelflsrql eslpathirg
      181 kcsvtllnet eslksylere dfffyslvyd pqqktlladk geirvgnryq aditdllkeg
      241 eedgrdqsrl etqvweahnp ltdkqidqfl vvarsvgtfa raldcsssvr qpslhmsaaa
      301 asrditlfha mdtlhkniyd iskaisalvp qggpvlcrde meewsasean lfeealekyg
      361 kdftdiqqdf lpwksltsii eyyymwkttd ryvqqkrlka aeaesklkqv yipnynkpnp
      421 nqisvnnvka gvvngtgapg qspgagrace scyttqsyqw yswgppnmqc rlcascwtyw
      481 kkygglkmpt rldgerpgpn rsnmsphglp arssgspkfa mktrqafylh ttkltriarr
      541 lcreilrpwh aarhpylpin saaikaecta rlpeasqspl vlkqavrkpl eavlryleth
      601 prppkpdpvk svssvlsslt pakvapvinn gsptilgkrs yeqhngvdgl anhgqarhmg
      661 psrnlllngk syptkvrlir ggslppvkrr rmnwidapdd vfymateetr kirkllssse
      721 tkraarrpyk pialrqsqal pprppppapv ndepivied
//
LOCUS       XP_011535610             758 aa            linear   PRI 05-AUG-2025
DEFINITION  metastasis-associated protein MTA1 isoform X10 [Homo sapiens].
ACCESSION   XP_011535610
VERSION     XP_011535610.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537308.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..758
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..758
                     /product="metastasis-associated protein MTA1 isoform X10"
                     /calculated_mol_wt=85496
     Region          64..227
                     /region_name="BAH_MTA"
                     /note="BAH, or Bromo Adjacent Homology domain, as present
                     in MTA1 and similar proteins. The Metastasis-associated
                     protein MTA1 is part of the NURD (nucleosome remodeling
                     and deacetylating) complex and plays a role in cellular
                     transformation and metastasis. BAH...; cd04709"
                     /db_xref="CDD:240060"
     Region          206..258
                     /region_name="ELM2"
                     /note="ELM2 domain; pfam01448"
                     /db_xref="CDD:460214"
     Region          326..371
                     /region_name="SANT_MTA3_like"
                     /note="Myb-Like Dna-Binding Domain of MTA3 and related
                     proteins; cd11661"
                     /db_xref="CDD:212559"
     Site            order(327,357..358,360..361,363..365,367..369)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212559"
     Region          427..480
                     /region_name="ZnF_GATA"
                     /note="zinc finger binding to DNA consensus sequence
                     [AT]GATA[AG]; smart00401"
                     /db_xref="CDD:214648"
     Region          503..580
                     /region_name="MTA_R1"
                     /note="MTA R1 domain; pfam17226"
                     /db_xref="CDD:465388"
     CDS             1..758
                     /gene="MTA1"
                     /coded_by="XM_011537308.3:16..2292"
                     /db_xref="GeneID:9112"
                     /db_xref="HGNC:HGNC:7410"
                     /db_xref="MIM:603526"
ORIGIN      
        1 mpgrdaaglf scdeehgrlg avcwqhshaw dpdcfcvcsp wslwpgvlga vrpptcpprg
       61 lplpadyvyf ensssnpyli rrieelnkta ngnveakvvc fyrrrdisst lialadkhar
      121 eieeemenpe mvdlpeklkh qlrhrelfls rqleslpath irgkcsvtll neteslksyl
      181 eredfffysl vydpqqktll adkgeirvgn ryqaditdll kegeedgrdq srletqvwea
      241 hnpltdkqid qflvvarsvg tfaraldcss svrqpslhms aaaasrditl fhamdtlhkn
      301 iydiskaisa lvpqggpvlc rdemeewsas eanlfeeale kygkdftdiq qdflpwkslt
      361 siieyyymwk ttdryvqqkr lkaaeaeskl kqvyipnynk pnpnqisvnn vkagvvngtg
      421 apgqspgagr acescyttqs yqwyswgppn mqcrlcascw tywkkygglk mptrldgerp
      481 gpnrsnmsph glparssgsp kfamktrqaf ylhttkltri arrlcreilr pwhaarhpyl
      541 pinsaaikae ctarlpeasq splvlkqavr kpleavlryl ethprppkpd pvksvssvls
      601 sltpakvapv inngsptilg krsyeqhngv dgnmkkrllm psrgtylgla nhgqarhmgp
      661 srnlllngks yptkvrlirg gslppvkrrr mnwidapddv fymateetrk irkllssset
      721 kraarrpykp ialrqsqalp prppppapvn depivied
//
LOCUS       XP_011535611             754 aa            linear   PRI 05-AUG-2025
DEFINITION  metastasis-associated protein MTA1 isoform X11 [Homo sapiens].
ACCESSION   XP_011535611
VERSION     XP_011535611.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537309.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..754
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..754
                     /product="metastasis-associated protein MTA1 isoform X11"
                     /calculated_mol_wt=85062
     Region          64..227
                     /region_name="BAH_MTA"
                     /note="BAH, or Bromo Adjacent Homology domain, as present
                     in MTA1 and similar proteins. The Metastasis-associated
                     protein MTA1 is part of the NURD (nucleosome remodeling
                     and deacetylating) complex and plays a role in cellular
                     transformation and metastasis. BAH...; cd04709"
                     /db_xref="CDD:240060"
     Region          206..258
                     /region_name="ELM2"
                     /note="ELM2 domain; pfam01448"
                     /db_xref="CDD:460214"
     Region          326..371
                     /region_name="SANT_MTA3_like"
                     /note="Myb-Like Dna-Binding Domain of MTA3 and related
                     proteins; cd11661"
                     /db_xref="CDD:212559"
     Site            order(327,357..358,360..361,363..365,367..369)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212559"
     Region          427..480
                     /region_name="ZnF_GATA"
                     /note="zinc finger binding to DNA consensus sequence
                     [AT]GATA[AG]; smart00401"
                     /db_xref="CDD:214648"
     Region          503..580
                     /region_name="MTA_R1"
                     /note="MTA R1 domain; pfam17226"
                     /db_xref="CDD:465388"
     CDS             1..754
                     /gene="MTA1"
                     /coded_by="XM_011537309.1:16..2280"
                     /db_xref="GeneID:9112"
                     /db_xref="HGNC:HGNC:7410"
                     /db_xref="MIM:603526"
ORIGIN      
        1 mpgrdaaglf scdeehgrlg avcwqhshaw dpdcfcvcsp wslwpgvlga vrpptcpprg
       61 lplpadyvyf ensssnpyli rrieelnkta ngnveakvvc fyrrrdisst lialadkhar
      121 eieeemenpe mvdlpeklkh qlrhrelfls rqleslpath irgkcsvtll neteslksyl
      181 eredfffysl vydpqqktll adkgeirvgn ryqaditdll kegeedgrdq srletqvwea
      241 hnpltdkqid qflvvarsvg tfaraldcss svrqpslhms aaaasrditl fhamdtlhkn
      301 iydiskaisa lvpqggpvlc rdemeewsas eanlfeeale kygkdftdiq qdflpwkslt
      361 siieyyymwk ttdryvqqkr lkaaeaeskl kqvyipnynk pnpnqisvnn vkagvvngtg
      421 apgqspgagr acescyttqs yqwyswgppn mqcrlcascw tywkkygglk mptrldgerp
      481 gpnrsnmsph glparssgsp kfamktrqaf ylhttkltri arrlcreilr pwhaarhpyl
      541 pinsaaikae ctarlpeasq splvlkqavr kpleavlryl ethprppkpd pvksvssvls
      601 sltpakvapv inngsptilg krsyeqhngv dgnmkkrllm psrglanhgq arhmgpsrnl
      661 llngksyptk vrlirggslp pvkrrrmnwi dapddvfyma teetrkirkl lsssetkraa
      721 rrpykpialr qsqalpprpp ppapvndepi vied
//
LOCUS       XP_011535612             742 aa            linear   PRI 05-AUG-2025
DEFINITION  metastasis-associated protein MTA1 isoform X12 [Homo sapiens].
ACCESSION   XP_011535612
VERSION     XP_011535612.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537310.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..742
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..742
                     /product="metastasis-associated protein MTA1 isoform X12"
                     /calculated_mol_wt=83649
     Region          64..227
                     /region_name="BAH_MTA"
                     /note="BAH, or Bromo Adjacent Homology domain, as present
                     in MTA1 and similar proteins. The Metastasis-associated
                     protein MTA1 is part of the NURD (nucleosome remodeling
                     and deacetylating) complex and plays a role in cellular
                     transformation and metastasis. BAH...; cd04709"
                     /db_xref="CDD:240060"
     Region          206..258
                     /region_name="ELM2"
                     /note="ELM2 domain; pfam01448"
                     /db_xref="CDD:460214"
     Region          326..371
                     /region_name="SANT_MTA3_like"
                     /note="Myb-Like Dna-Binding Domain of MTA3 and related
                     proteins; cd11661"
                     /db_xref="CDD:212559"
     Site            order(327,357..358,360..361,363..365,367..369)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212559"
     Region          427..480
                     /region_name="ZnF_GATA"
                     /note="zinc finger binding to DNA consensus sequence
                     [AT]GATA[AG]; smart00401"
                     /db_xref="CDD:214648"
     Region          503..580
                     /region_name="MTA_R1"
                     /note="MTA R1 domain; pfam17226"
                     /db_xref="CDD:465388"
     CDS             1..742
                     /gene="MTA1"
                     /coded_by="XM_011537310.1:16..2244"
                     /db_xref="GeneID:9112"
                     /db_xref="HGNC:HGNC:7410"
                     /db_xref="MIM:603526"
ORIGIN      
        1 mpgrdaaglf scdeehgrlg avcwqhshaw dpdcfcvcsp wslwpgvlga vrpptcpprg
       61 lplpadyvyf ensssnpyli rrieelnkta ngnveakvvc fyrrrdisst lialadkhar
      121 eieeemenpe mvdlpeklkh qlrhrelfls rqleslpath irgkcsvtll neteslksyl
      181 eredfffysl vydpqqktll adkgeirvgn ryqaditdll kegeedgrdq srletqvwea
      241 hnpltdkqid qflvvarsvg tfaraldcss svrqpslhms aaaasrditl fhamdtlhkn
      301 iydiskaisa lvpqggpvlc rdemeewsas eanlfeeale kygkdftdiq qdflpwkslt
      361 siieyyymwk ttdryvqqkr lkaaeaeskl kqvyipnynk pnpnqisvnn vkagvvngtg
      421 apgqspgagr acescyttqs yqwyswgppn mqcrlcascw tywkkygglk mptrldgerp
      481 gpnrsnmsph glparssgsp kfamktrqaf ylhttkltri arrlcreilr pwhaarhpyl
      541 pinsaaikae ctarlpeasq splvlkqavr kpleavlryl ethprppkpd pvksvssvls
      601 sltpakvapv inngsptilg krsyeqhngv dglanhgqar hmgpsrnlll ngksyptkvr
      661 lirggslppv krrrmnwida pddvfymate etrkirklls ssetkraarr pykpialrqs
      721 qalpprpppp apvndepivi ed
//
LOCUS       XP_047287860             719 aa            linear   PRI 05-AUG-2025
DEFINITION  metastasis-associated protein MTA1 isoform X13 [Homo sapiens].
ACCESSION   XP_047287860
VERSION     XP_047287860.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431904.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..719
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..719
                     /product="metastasis-associated protein MTA1 isoform X13"
                     /calculated_mol_wt=81090
     Region          3..188
                     /region_name="BAH_MTA"
                     /note="BAH, or Bromo Adjacent Homology domain, as present
                     in MTA1 and similar proteins. The Metastasis-associated
                     protein MTA1 is part of the NURD (nucleosome remodeling
                     and deacetylating) complex and plays a role in cellular
                     transformation and metastasis. BAH...; cd04709"
                     /db_xref="CDD:240060"
     Region          167..219
                     /region_name="ELM2"
                     /note="ELM2 domain; pfam01448"
                     /db_xref="CDD:460214"
     Region          287..332
                     /region_name="SANT_MTA3_like"
                     /note="Myb-Like Dna-Binding Domain of MTA3 and related
                     proteins; cd11661"
                     /db_xref="CDD:212559"
     Site            order(288,318..319,321..322,324..326,328..330)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212559"
     Region          388..441
                     /region_name="ZnF_GATA"
                     /note="zinc finger binding to DNA consensus sequence
                     [AT]GATA[AG]; smart00401"
                     /db_xref="CDD:214648"
     Region          464..541
                     /region_name="MTA_R1"
                     /note="MTA R1 domain; pfam17226"
                     /db_xref="CDD:465388"
     CDS             1..719
                     /gene="MTA1"
                     /coded_by="XM_047431904.1:210..2369"
                     /db_xref="GeneID:9112"
                     /db_xref="HGNC:HGNC:7410"
                     /db_xref="MIM:603526"
ORIGIN      
        1 maanmyrvgd yvyfensssn pylirrieel nktangnvea kvvcfyrrrd isstlialad
       61 khatlsvcyk agpgadngee geieeemenp emvdlpeklk hqlrhrelfl srqleslpat
      121 hirgkcsvtl lneteslksy leredfffys lvydpqqktl ladkgeirvg nryqaditdl
      181 lkegeedgrd qsrletqvwe ahnpltdkqi dqflvvarsv gtfaraldcs ssvrqpslhm
      241 saaaasrdit lfhamdtlhk niydiskais alvpqggpvl crdemeewsa seanlfeeal
      301 ekygkdftdi qqdflpwksl tsiieyyymw kttdryvqqk rlkaaeaesk lkqvyipnyn
      361 kpnpnqisvn nvkagvvngt gapgqspgag racescyttq syqwyswgpp nmqcrlcasc
      421 wtywkkyggl kmptrldger pgpnrsnmsp hglparssgs pkfamktrqa fylhttkltr
      481 iarrlcreil rpwhaarhpy lpinsaaika ectarlpeas qsplvlkqav rkpleavlry
      541 lethprppkp dpvksvssvl ssltpakvap vinngsptil gkrsyeqhng vdgnmkkrll
      601 mpsrgtylgl anhgqarhmg psrnlllngk syptkvrlir ggslppvkrr rmnwidapdd
      661 vfymateetr kirkllssse tkraarrpyk pialrqsqal pprppppapv ndepivied
//
LOCUS       XP_047287862             702 aa            linear   PRI 05-AUG-2025
DEFINITION  metastasis-associated protein MTA1 isoform X14 [Homo sapiens].
ACCESSION   XP_047287862
VERSION     XP_047287862.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431906.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..702
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..702
                     /product="metastasis-associated protein MTA1 isoform X14"
                     /calculated_mol_wt=79496
     Region          3..171
                     /region_name="BAH_MTA"
                     /note="BAH, or Bromo Adjacent Homology domain, as present
                     in MTA1 and similar proteins. The Metastasis-associated
                     protein MTA1 is part of the NURD (nucleosome remodeling
                     and deacetylating) complex and plays a role in cellular
                     transformation and metastasis. BAH...; cd04709"
                     /db_xref="CDD:240060"
     Region          150..202
                     /region_name="ELM2"
                     /note="ELM2 domain; pfam01448"
                     /db_xref="CDD:460214"
     Region          270..315
                     /region_name="SANT_MTA3_like"
                     /note="Myb-Like Dna-Binding Domain of MTA3 and related
                     proteins; cd11661"
                     /db_xref="CDD:212559"
     Site            order(271,301..302,304..305,307..309,311..313)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212559"
     Region          371..424
                     /region_name="ZnF_GATA"
                     /note="zinc finger binding to DNA consensus sequence
                     [AT]GATA[AG]; smart00401"
                     /db_xref="CDD:214648"
     Region          447..524
                     /region_name="MTA_R1"
                     /note="MTA R1 domain; pfam17226"
                     /db_xref="CDD:465388"
     CDS             1..702
                     /gene="MTA1"
                     /coded_by="XM_047431906.1:210..2318"
                     /db_xref="GeneID:9112"
                     /db_xref="HGNC:HGNC:7410"
                     /db_xref="MIM:603526"
ORIGIN      
        1 maanmyrvgd yvyfensssn pylirrieel nktangnvea kvvcfyrrrd isstlialad
       61 khareieeem enpemvdlpe klkhqlrhre lflsrqlesl pathirgkcs vtllnetesl
      121 ksyleredff fyslvydpqq ktlladkgei rvgnryqadi tdllkegeed grdqsrletq
      181 vweahnpltd kqidqflvva rsvgtfaral dcsssvrqps lhmsaaaasr ditlfhamdt
      241 lhkniydisk aisalvpqgg pvlcrdemee wsaseanlfe ealekygkdf tdiqqdflpw
      301 ksltsiieyy ymwkttdryv qqkrlkaaea esklkqvyip nynkpnpnqi svnnvkagvv
      361 ngtgapgqsp gagracescy ttqsyqwysw gppnmqcrlc ascwtywkky gglkmptrld
      421 gerpgpnrsn msphglpars sgspkfamkt rqafylhttk ltriarrlcr eilrpwhaar
      481 hpylpinsaa ikaectarlp easqsplvlk qavrkpleav lrylethprp pkpdpvksvs
      541 svlssltpak vapvinngsp tilgkrsyeq hngvdgnmkk rllmpsrgty lglanhgqar
      601 hmgpsrnlll ngksyptkvr lirggslppv krrrmnwida pddvfymate etrkirklls
      661 ssetkraarr pykpialrqs qalpprpppp apvndepivi ed
//
LOCUS       XP_047287864             686 aa            linear   PRI 05-AUG-2025
DEFINITION  metastasis-associated protein MTA1 isoform X15 [Homo sapiens].
ACCESSION   XP_047287864
VERSION     XP_047287864.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431908.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..686
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..686
                     /product="metastasis-associated protein MTA1 isoform X15"
                     /calculated_mol_wt=77649
     Region          3..171
                     /region_name="BAH_MTA"
                     /note="BAH, or Bromo Adjacent Homology domain, as present
                     in MTA1 and similar proteins. The Metastasis-associated
                     protein MTA1 is part of the NURD (nucleosome remodeling
                     and deacetylating) complex and plays a role in cellular
                     transformation and metastasis. BAH...; cd04709"
                     /db_xref="CDD:240060"
     Region          150..202
                     /region_name="ELM2"
                     /note="ELM2 domain; pfam01448"
                     /db_xref="CDD:460214"
     Region          270..315
                     /region_name="SANT_MTA3_like"
                     /note="Myb-Like Dna-Binding Domain of MTA3 and related
                     proteins; cd11661"
                     /db_xref="CDD:212559"
     Site            order(271,301..302,304..305,307..309,311..313)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212559"
     Region          371..424
                     /region_name="ZnF_GATA"
                     /note="zinc finger binding to DNA consensus sequence
                     [AT]GATA[AG]; smart00401"
                     /db_xref="CDD:214648"
     Region          447..524
                     /region_name="MTA_R1"
                     /note="MTA R1 domain; pfam17226"
                     /db_xref="CDD:465388"
     CDS             1..686
                     /gene="MTA1"
                     /coded_by="XM_047431908.1:210..2270"
                     /db_xref="GeneID:9112"
                     /db_xref="HGNC:HGNC:7410"
                     /db_xref="MIM:603526"
ORIGIN      
        1 maanmyrvgd yvyfensssn pylirrieel nktangnvea kvvcfyrrrd isstlialad
       61 khareieeem enpemvdlpe klkhqlrhre lflsrqlesl pathirgkcs vtllnetesl
      121 ksyleredff fyslvydpqq ktlladkgei rvgnryqadi tdllkegeed grdqsrletq
      181 vweahnpltd kqidqflvva rsvgtfaral dcsssvrqps lhmsaaaasr ditlfhamdt
      241 lhkniydisk aisalvpqgg pvlcrdemee wsaseanlfe ealekygkdf tdiqqdflpw
      301 ksltsiieyy ymwkttdryv qqkrlkaaea esklkqvyip nynkpnpnqi svnnvkagvv
      361 ngtgapgqsp gagracescy ttqsyqwysw gppnmqcrlc ascwtywkky gglkmptrld
      421 gerpgpnrsn msphglpars sgspkfamkt rqafylhttk ltriarrlcr eilrpwhaar
      481 hpylpinsaa ikaectarlp easqsplvlk qavrkpleav lrylethprp pkpdpvksvs
      541 svlssltpak vapvinngsp tilgkrsyeq hngvdglanh gqarhmgpsr nlllngksyp
      601 tkvrlirggs lppvkrrrmn widapddvfy mateetrkir kllsssetkr aarrpykpia
      661 lrqsqalppr ppppapvnde pivied
//
LOCUS       XP_047287865             459 aa            linear   PRI 05-AUG-2025
DEFINITION  metastasis-associated protein MTA1 isoform X16 [Homo sapiens].
ACCESSION   XP_047287865
VERSION     XP_047287865.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431909.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..459
                     /product="metastasis-associated protein MTA1 isoform X16"
                     /calculated_mol_wt=51737
     Region          50..217
                     /region_name="BAH_MTA"
                     /note="BAH, or Bromo Adjacent Homology domain, as present
                     in MTA1 and similar proteins. The Metastasis-associated
                     protein MTA1 is part of the NURD (nucleosome remodeling
                     and deacetylating) complex and plays a role in cellular
                     transformation and metastasis. BAH...; cd04709"
                     /db_xref="CDD:240060"
     Region          196..248
                     /region_name="ELM2"
                     /note="ELM2 domain; pfam01448"
                     /db_xref="CDD:460214"
     Region          316..361
                     /region_name="SANT_MTA3_like"
                     /note="Myb-Like Dna-Binding Domain of MTA3 and related
                     proteins; cd11661"
                     /db_xref="CDD:212559"
     Site            order(317,347..348,350..351,353..355,357..359)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212559"
     CDS             1..459
                     /gene="MTA1"
                     /coded_by="XM_047431909.1:172..1551"
                     /db_xref="GeneID:9112"
                     /db_xref="HGNC:HGNC:7410"
                     /db_xref="MIM:603526"
ORIGIN      
        1 mawalaclwa ghqpvrgttt lldcsgraae pdahhveknp qacdrvrpvp stprssrrgf
       61 qtangnveak vvcfyrrrdi sstlialadk hatlsvcyka gpgadngeeg eieeemenpe
      121 mvdlpeklkh qlrhrelfls rqleslpath irgkcsvtll neteslksyl eredfffysl
      181 vydpqqktll adkgeirvgn ryqaditdll kegeedgrdq srletqvwea hnpltdkqid
      241 qflvvarsvg tfaraldcss svrqpslhms aaaasrditl fhamdtlhkn iydiskaisa
      301 lvpqggpvlc rdemeewsas eanlfeeale kygkdftdiq qdflpwkslt siieyyymwk
      361 ttdryvqqkr lkaaeaeskl kqvyipnynk pnpnqisvnn vkagvvngtg apgqspgagr
      421 acescymssl rilldileei wwlenanpvr wreartkpq
//
LOCUS       XP_047287866             486 aa            linear   PRI 05-AUG-2025
DEFINITION  metastasis-associated protein MTA1 isoform X17 [Homo sapiens].
ACCESSION   XP_047287866
VERSION     XP_047287866.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431910.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..486
                     /product="metastasis-associated protein MTA1 isoform X17"
                     /calculated_mol_wt=54886
     Region          64..244
                     /region_name="BAH_MTA"
                     /note="BAH, or Bromo Adjacent Homology domain, as present
                     in MTA1 and similar proteins. The Metastasis-associated
                     protein MTA1 is part of the NURD (nucleosome remodeling
                     and deacetylating) complex and plays a role in cellular
                     transformation and metastasis. BAH...; cd04709"
                     /db_xref="CDD:240060"
     Region          223..275
                     /region_name="ELM2"
                     /note="ELM2 domain; pfam01448"
                     /db_xref="CDD:460214"
     Region          343..388
                     /region_name="SANT_MTA3_like"
                     /note="Myb-Like Dna-Binding Domain of MTA3 and related
                     proteins; cd11661"
                     /db_xref="CDD:212559"
     Site            order(344,374..375,377..378,380..382,384..386)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212559"
     CDS             1..486
                     /gene="MTA1"
                     /coded_by="XM_047431910.1:16..1476"
                     /db_xref="GeneID:9112"
                     /db_xref="HGNC:HGNC:7410"
                     /db_xref="MIM:603526"
ORIGIN      
        1 mpgrdaaglf scdeehgrlg avcwqhshaw dpdcfcvcsp wslwpgvlga vrpptcpprg
       61 lplpadyvyf ensssnpyli rrieelnkta ngnveakvvc fyrrrdisst lialadkhat
      121 lsvcykagpg adngeegeie eemenpemvd lpeklkhqlr hrelflsrql eslpathirg
      181 kcsvtllnet eslksylere dfffyslvyd pqqktlladk geirvgnryq aditdllkeg
      241 eedgrdqsrl etqvweahnp ltdkqidqfl vvarsvgtfa raldcsssvr qpslhmsaaa
      301 asrditlfha mdtlhkniyd iskaisalvp qggpvlcrde meewsasean lfeealekyg
      361 kdftdiqqdf lpwksltsii eyyymwkttd ryvqqkrlka aeaesklkqv yipnynkpnp
      421 nqisvnnvka gvvngtgapg qspgagrace scymsslril ldileeiwwl enanpvrwre
      481 artkpq
//
LOCUS       XP_047287867             993 aa            linear   PRI 05-AUG-2025
DEFINITION  ribosome quality control complex subunit NEMF isoform X1 [Homo
            sapiens].
ACCESSION   XP_047287867
VERSION     XP_047287867.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431911.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..993
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..993
                     /product="ribosome quality control complex subunit NEMF
                     isoform X1"
                     /calculated_mol_wt=113993
     Region          6..644
                     /region_name="RqcH_arch"
                     /note="ribosome rescue protein RqcH, archaeal type;
                     NF041120"
                     /db_xref="CDD:469043"
     Region          <658..776
                     /region_name="COG5137"
                     /note="Histone chaperone involved in gene silencing
                     [Transcription / Chromatin structure and dynamics]"
                     /db_xref="CDD:227466"
     CDS             1..993
                     /gene="NEMF"
                     /gene_synonym="IDDSAPN; NY-CO-1; RQC2; SDCCAG1"
                     /coded_by="XM_047431911.1:36..3017"
                     /db_xref="GeneID:9147"
                     /db_xref="HGNC:HGNC:10663"
                     /db_xref="MIM:608378"
ORIGIN      
        1 mksrfstidl ravlaelnas llgmrvnnvy dvdnktylir lqkpdfkatl llesgiriht
       61 tefewpknmm pssfamkcrk hlksrrlvsa kqlgvdrivd fqfgsdeaay hliielydrg
      121 nivltdyeyv ilnilrfrtd eaddvkfavr erypldhara aeplltlerl teivasapkg
      181 ellkrvlnpl lpygpalieh cllengfsgn vkvdekletk diekvlvslq kaedymktts
      241 nfsgkgyiiq kreikpslea dkpvedilty eefhpflfsq hsqcpyiefe sfdkavdefy
      301 skiegqkidl kalqqekqal kkldnvrkdh enrlealqqa qeidklkgel iemnlqivdr
      361 aiqvvrsala nqidwteigl ivkeaqaqgd pvasaikelk lqtnhvtmll rnpyllseee
      421 dddvdgdvnv ekneteppkg kkkkqknkql qkpqknkpll vdvdlslsay anakkyydhk
      481 ryaakktqkt veaaekafks aekktkqtlk evqtvtsiqk arkvywfekf lwfissenyl
      541 iiggrdqqqn eiivkryltp gdiyvhadlh gatscviknp tgepipprtl teagtmalcy
      601 saawdarvit sawwvyhhqv sktaptgeyl ttgsfmirgk knflppsylm mgfsflfkvd
      661 escvwrhqge rkvrvqdedm etlasctsel iseemeqldg gdtssdedke ehetpvevel
      721 mtqvdqedit lqsgrdelne eliqeessed egeyeevrkd qdsvgemkde geetlnypdt
      781 tidlshlqpq rsiqklaske essnssdsks qsrrhlsake rremkkkklp sdsgdleale
      841 gkdkekestv hiethqntsk nvaavqpmkr gqkskmkkmk ekykdqdeed relimkllgs
      901 agsnkeekgk kgkkgktkde pvkkqpqkpr ggqrvsdnik ketpflevit helqdfavdd
      961 phddkltflf lyvrnrkski winremrkty lil
//
LOCUS       XP_047287868             847 aa            linear   PRI 05-AUG-2025
DEFINITION  ribosome quality control complex subunit NEMF isoform X2 [Homo
            sapiens].
ACCESSION   XP_047287868
VERSION     XP_047287868.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431912.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..847
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..847
                     /product="ribosome quality control complex subunit NEMF
                     isoform X2"
                     /calculated_mol_wt=96754
     Region          <40..415
                     /region_name="RqcH_arch"
                     /note="ribosome rescue protein RqcH, archaeal type;
                     NF041120"
                     /db_xref="CDD:469043"
     Region          <429..547
                     /region_name="COG5137"
                     /note="Histone chaperone involved in gene silencing
                     [Transcription / Chromatin structure and dynamics]"
                     /db_xref="CDD:227466"
     Region          746..837
                     /region_name="NFACT-C"
                     /note="NFACT protein C-terminal domain; pfam11923"
                     /db_xref="CDD:432191"
     CDS             1..847
                     /gene="NEMF"
                     /gene_synonym="IDDSAPN; NY-CO-1; RQC2; SDCCAG1"
                     /coded_by="XM_047431912.1:113..2656"
                     /db_xref="GeneID:9147"
                     /db_xref="HGNC:HGNC:10663"
                     /db_xref="MIM:608378"
ORIGIN      
        1 mdsrvmskwm knlklkgyii qkreikpsle adkpvedilt yeefhpflfs qhsqcpyief
       61 esfdkavdef yskiegqkid lkalqqekqa lkkldnvrkd henrlealqq aqeidklkge
      121 liemnlqivd raiqvvrsal anqidwteig livkeaqaqg dpvasaikel klqtnhvtml
      181 lrnpyllsee edddvdgdvn vekneteppk gkkkkqknkq lqkpqknkpl lvdvdlslsa
      241 yanakkyydh kryaakktqk tveaaekafk saekktkqtl kevqtvtsiq karkvywfek
      301 flwfisseny liiggrdqqq neiivkrylt pgdiyvhadl hgatscvikn ptgepipprt
      361 lteagtmalc ysaawdarvi tsawwvyhhq vsktaptgey lttgsfmirg kknflppsyl
      421 mmgfsflfkv descvwrhqg erkvrvqded metlasctse liseemeqld ggdtssdedk
      481 eehetpveve lmtqvdqedi tlqsgrdeln eeliqeesse degeyeevrk dqdsvgemkd
      541 egeetlnypd ttidlshlqp qrsiqklask eessnssdsk sqsrrhlsak erremkkkkl
      601 psdsgdleal egkdkekest vhiethqnts knvaavqpmk rgqkskmkkm kekykdqdee
      661 drelimkllg sagsnkeekg kkgkkgktkd epvkkqpqkp rggqrvsdni kketpflevi
      721 thelqdfavd dphddkeeqd ldqqgneenl fdsltgqphp edvllfaipi capyttmtny
      781 kykvkltpgv qkkgkaakta lnsfmhskea tarekdlfrs vkdtdlsrni pgkvkvsapn
      841 llnvkrk
//
LOCUS       XP_016877250             847 aa            linear   PRI 05-AUG-2025
DEFINITION  ribosome quality control complex subunit NEMF isoform X2 [Homo
            sapiens].
ACCESSION   XP_016877250
VERSION     XP_016877250.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021761.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..847
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..847
                     /product="ribosome quality control complex subunit NEMF
                     isoform X2"
                     /calculated_mol_wt=96754
     Region          <40..415
                     /region_name="RqcH_arch"
                     /note="ribosome rescue protein RqcH, archaeal type;
                     NF041120"
                     /db_xref="CDD:469043"
     Region          <429..547
                     /region_name="COG5137"
                     /note="Histone chaperone involved in gene silencing
                     [Transcription / Chromatin structure and dynamics]"
                     /db_xref="CDD:227466"
     Region          746..837
                     /region_name="NFACT-C"
                     /note="NFACT protein C-terminal domain; pfam11923"
                     /db_xref="CDD:432191"
     CDS             1..847
                     /gene="NEMF"
                     /gene_synonym="IDDSAPN; NY-CO-1; RQC2; SDCCAG1"
                     /coded_by="XM_017021761.2:820..3363"
                     /db_xref="GeneID:9147"
                     /db_xref="HGNC:HGNC:10663"
                     /db_xref="MIM:608378"
ORIGIN      
        1 mdsrvmskwm knlklkgyii qkreikpsle adkpvedilt yeefhpflfs qhsqcpyief
       61 esfdkavdef yskiegqkid lkalqqekqa lkkldnvrkd henrlealqq aqeidklkge
      121 liemnlqivd raiqvvrsal anqidwteig livkeaqaqg dpvasaikel klqtnhvtml
      181 lrnpyllsee edddvdgdvn vekneteppk gkkkkqknkq lqkpqknkpl lvdvdlslsa
      241 yanakkyydh kryaakktqk tveaaekafk saekktkqtl kevqtvtsiq karkvywfek
      301 flwfisseny liiggrdqqq neiivkrylt pgdiyvhadl hgatscvikn ptgepipprt
      361 lteagtmalc ysaawdarvi tsawwvyhhq vsktaptgey lttgsfmirg kknflppsyl
      421 mmgfsflfkv descvwrhqg erkvrvqded metlasctse liseemeqld ggdtssdedk
      481 eehetpveve lmtqvdqedi tlqsgrdeln eeliqeesse degeyeevrk dqdsvgemkd
      541 egeetlnypd ttidlshlqp qrsiqklask eessnssdsk sqsrrhlsak erremkkkkl
      601 psdsgdleal egkdkekest vhiethqnts knvaavqpmk rgqkskmkkm kekykdqdee
      661 drelimkllg sagsnkeekg kkgkkgktkd epvkkqpqkp rggqrvsdni kketpflevi
      721 thelqdfavd dphddkeeqd ldqqgneenl fdsltgqphp edvllfaipi capyttmtny
      781 kykvkltpgv qkkgkaakta lnsfmhskea tarekdlfrs vkdtdlsrni pgkvkvsapn
      841 llnvkrk
//
LOCUS       XP_011535619             586 aa            linear   PRI 05-AUG-2025
DEFINITION  ribosome quality control complex subunit NEMF isoform X3 [Homo
            sapiens].
ACCESSION   XP_011535619
VERSION     XP_011535619.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537317.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..586
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..586
                     /product="ribosome quality control complex subunit NEMF
                     isoform X3"
                     /calculated_mol_wt=67266
     Region          6..>580
                     /region_name="RqcH_arch"
                     /note="ribosome rescue protein RqcH, archaeal type;
                     NF041120"
                     /db_xref="CDD:469043"
     CDS             1..586
                     /gene="NEMF"
                     /gene_synonym="IDDSAPN; NY-CO-1; RQC2; SDCCAG1"
                     /coded_by="XM_011537317.4:36..1796"
                     /db_xref="GeneID:9147"
                     /db_xref="HGNC:HGNC:10663"
                     /db_xref="MIM:608378"
ORIGIN      
        1 mksrfstidl ravlaelnas llgmrvnnvy dvdnktylir lqkpdfkatl llesgiriht
       61 tefewpknmm pssfamkcrk hlksrrlvsa kqlgvdrivd fqfgsdeaay hliielydrg
      121 nivltdyeyv ilnilrfrtd eaddvkfavr erypldhara aeplltlerl teivasapkg
      181 ellkrvlnpl lpygpalieh cllengfsgn vkvdekletk diekvlvslq kaedymktts
      241 nfsgkgyiiq kreikpslea dkpvedilty eefhpflfsq hsqcpyiefe sfdkavdefy
      301 skiegqkidl kalqqekqal kkldnvrkdh enrlealqqa qeidklkgel iemnlqivdr
      361 aiqvvrsala nqidwteigl ivkeaqaqgd pvasaikelk lqtnhvtmll rnpyllseee
      421 dddvdgdvnv ekneteppkg kkkkqknkql qkpqknkpll vdvdlslsay anakkyydhk
      481 ryaakktqkt veaaekafks aekktkqtlk evqtvtsiqk arkvywfekf lwfissenyl
      541 iiggrdqqqn eiivkryltp gdiyvhadlh gatscviknp tgiypr
//
LOCUS       XP_011535620             544 aa            linear   PRI 05-AUG-2025
DEFINITION  ribosome quality control complex subunit NEMF isoform X4 [Homo
            sapiens].
ACCESSION   XP_011535620
VERSION     XP_011535620.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537318.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..544
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..544
                     /product="ribosome quality control complex subunit NEMF
                     isoform X4"
                     /calculated_mol_wt=62138
     Region          5..>361
                     /region_name="RqcH"
                     /note="Ribosome quality control (RQC) protein RqcH,
                     Rqc2/NEMF/Tae2 family, contains fibronectin-(FbpA) and
                     RNA- (NFACT) binding domains [Translation, ribosomal
                     structure and biogenesis, Posttranslational modification,
                     protein turnover, chaperones]; COG1293"
                     /db_xref="CDD:440904"
     CDS             1..544
                     /gene="NEMF"
                     /gene_synonym="IDDSAPN; NY-CO-1; RQC2; SDCCAG1"
                     /coded_by="XM_011537318.4:36..1670"
                     /db_xref="GeneID:9147"
                     /db_xref="HGNC:HGNC:10663"
                     /db_xref="MIM:608378"
ORIGIN      
        1 mksrfstidl ravlaelnas llgmrvnnvy dvdnktylir lqkpdfkatl llesgiriht
       61 tefewpknmm pssfamkcrk hlksrrlvsa kqlgvdrivd fqfgsdeaay hliielydrg
      121 nivltdyeyv ilnilrfrtd eaddvkfavr erypldhara aeplltlerl teivasapkg
      181 ellkrvlnpl lpygpalieh cllengfsgn vkvdekletk diekvlvslq kaedymktts
      241 nfsgkgyiiq kreikpslea dkpvedilty eefhpflfsq hsqcpyiefe sfdkavdefy
      301 skiegqkidl kalqqekqal kkldnvrkdh enrlealqqa qeidklkgel iemnlqivdr
      361 aiqvvrsala nqidwteigl ivkeaqaqgd pvasaikelk lqtnhvtmll rnpyllseee
      421 dddvdgdvnv ekneteppkg kkkkqknkql qkpqknkpll vdvdlslsay anakkyydhk
      481 ryaakktqkt veaaekafks aekktkqtlk evqtvtsiqk arkvyclgfs flslitagrs
      541 gsrl
//
LOCUS       XP_047287869            1099 aa            linear   PRI 05-AUG-2025
DEFINITION  mitotic deacetylase-associated SANT domain protein isoform X1 [Homo
            sapiens].
ACCESSION   XP_047287869
VERSION     XP_047287869.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431913.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1099
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1099
                     /product="mitotic deacetylase-associated SANT domain
                     protein isoform X1"
                     /calculated_mol_wt=120603
     Region          723..778
                     /region_name="ELM2"
                     /note="ELM2 domain; pfam01448"
                     /db_xref="CDD:460214"
     Region          832..876
                     /region_name="SANT"
                     /note="'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains.
                     Tandem copies of the domain bind telomeric DNA tandem
                     repeatsas part of the capping complex. Binding is sequence
                     dependent for repeats which contain the G/C rich motif
                     [C2-3 A (CA)1-6]. The domain is...; cl21498"
                     /db_xref="CDD:473887"
     Site            order(833,862..863,865..866,868..870,872..874)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212559"
     CDS             1..1099
                     /gene="MIDEAS"
                     /gene_synonym="C14orf117; C14orf43; c14_5541; ELMSAN1;
                     LSR68"
                     /coded_by="XM_047431913.1:547..3846"
                     /db_xref="GeneID:91748"
                     /db_xref="HGNC:HGNC:19853"
                     /db_xref="MIM:621074"
ORIGIN      
        1 mnlqaqpkaq nkrkrclfgg qepapkeqpp plqppqqsir vkeeqylghe gpggavstsq
       61 pvelpppssl allnsvvygp ertsaamlsq qvasvkwpns vmapgrgper gggggvsdss
      121 wqqqpgqppp hstwnchsls lysatkgsph pgvgvptyyn hpealkreka ggpqldryvr
      181 pmmpqkvqle vgrpqaplns fhaakkppnq slplqpfqla fghqvnrqvf rqgppppnpv
      241 aafppqkqqq qqqpqqqqqq qqaalpqmpl fenfysmpqq psqqpqdfgl qpagplgqsh
      301 lahhsmapyp fppnpdmnpe lrkallqdsa pqpalpqvqi pfprrsrrls kegilppsal
      361 dgagtqpgqe atgnlflhhw plqqpppgsl gqphpealgf plelresqll pdgerlapng
      421 rereapamgs eegmravstg dcgqvlrggv iqstrrrrra sqeanlltla qkavelaslq
      481 nakdgsgsee krksvlastt kcgvefseps latkrareds gmvpliipvs vpvrtvdpte
      541 aaqagglded gkgpeqnpae hkpsvivtrr rstripgtda qaqaedmnvk legepsvrkp
      601 kqrprpepli iptkagtfia ppvysnitpy qshlrspvrl adhpsersfe lppytpppil
      661 spvregsgly fnaiiststi papppitpks ahrtllrtns aevtppvlsv mgeatpvsie
      721 prinvgsrfq aeiplmrdra laaadphkad lvwqpwedle ssrekqrqve dlltaacssi
      781 fpgagtnqel alhclhesrg diletlnkll lkkplrphnh platyhytgs dqwkmaerkl
      841 fnkgiaiykk dfflvqkliq tktvaqcvef yytykkqvki grngtltfgd vdtsdeksaq
      901 eevevdikts qkfprvplpr respseerle pkrevkeprk egeeevpeiq ekeeqeegre
      961 rsrraaavka tqtlqanesa sdililrshe snapgsaggq asekpregtg ksrralpfse
     1021 kkkktetfsk tqnqentfpc kkcgrvfykv ksrsahmksh aeqekkaaal rlkekeaaaa
     1081 aaaahqqalr eesgagdkg
//
LOCUS       XP_047287870            1099 aa            linear   PRI 05-AUG-2025
DEFINITION  mitotic deacetylase-associated SANT domain protein isoform X1 [Homo
            sapiens].
ACCESSION   XP_047287870
VERSION     XP_047287870.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431914.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1099
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1099
                     /product="mitotic deacetylase-associated SANT domain
                     protein isoform X1"
                     /calculated_mol_wt=120603
     Region          723..778
                     /region_name="ELM2"
                     /note="ELM2 domain; pfam01448"
                     /db_xref="CDD:460214"
     Region          832..876
                     /region_name="SANT"
                     /note="'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains.
                     Tandem copies of the domain bind telomeric DNA tandem
                     repeatsas part of the capping complex. Binding is sequence
                     dependent for repeats which contain the G/C rich motif
                     [C2-3 A (CA)1-6]. The domain is...; cl21498"
                     /db_xref="CDD:473887"
     Site            order(833,862..863,865..866,868..870,872..874)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212559"
     CDS             1..1099
                     /gene="MIDEAS"
                     /gene_synonym="C14orf117; C14orf43; c14_5541; ELMSAN1;
                     LSR68"
                     /coded_by="XM_047431914.1:643..3942"
                     /db_xref="GeneID:91748"
                     /db_xref="HGNC:HGNC:19853"
                     /db_xref="MIM:621074"
ORIGIN      
        1 mnlqaqpkaq nkrkrclfgg qepapkeqpp plqppqqsir vkeeqylghe gpggavstsq
       61 pvelpppssl allnsvvygp ertsaamlsq qvasvkwpns vmapgrgper gggggvsdss
      121 wqqqpgqppp hstwnchsls lysatkgsph pgvgvptyyn hpealkreka ggpqldryvr
      181 pmmpqkvqle vgrpqaplns fhaakkppnq slplqpfqla fghqvnrqvf rqgppppnpv
      241 aafppqkqqq qqqpqqqqqq qqaalpqmpl fenfysmpqq psqqpqdfgl qpagplgqsh
      301 lahhsmapyp fppnpdmnpe lrkallqdsa pqpalpqvqi pfprrsrrls kegilppsal
      361 dgagtqpgqe atgnlflhhw plqqpppgsl gqphpealgf plelresqll pdgerlapng
      421 rereapamgs eegmravstg dcgqvlrggv iqstrrrrra sqeanlltla qkavelaslq
      481 nakdgsgsee krksvlastt kcgvefseps latkrareds gmvpliipvs vpvrtvdpte
      541 aaqagglded gkgpeqnpae hkpsvivtrr rstripgtda qaqaedmnvk legepsvrkp
      601 kqrprpepli iptkagtfia ppvysnitpy qshlrspvrl adhpsersfe lppytpppil
      661 spvregsgly fnaiiststi papppitpks ahrtllrtns aevtppvlsv mgeatpvsie
      721 prinvgsrfq aeiplmrdra laaadphkad lvwqpwedle ssrekqrqve dlltaacssi
      781 fpgagtnqel alhclhesrg diletlnkll lkkplrphnh platyhytgs dqwkmaerkl
      841 fnkgiaiykk dfflvqkliq tktvaqcvef yytykkqvki grngtltfgd vdtsdeksaq
      901 eevevdikts qkfprvplpr respseerle pkrevkeprk egeeevpeiq ekeeqeegre
      961 rsrraaavka tqtlqanesa sdililrshe snapgsaggq asekpregtg ksrralpfse
     1021 kkkktetfsk tqnqentfpc kkcgrvfykv ksrsahmksh aeqekkaaal rlkekeaaaa
     1081 aaaahqqalr eesgagdkg
//
LOCUS       XP_005268263            1099 aa            linear   PRI 05-AUG-2025
DEFINITION  mitotic deacetylase-associated SANT domain protein isoform X1 [Homo
            sapiens].
ACCESSION   XP_005268263
VERSION     XP_005268263.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005268206.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1099
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1099
                     /product="mitotic deacetylase-associated SANT domain
                     protein isoform X1"
                     /calculated_mol_wt=120603
     Region          723..778
                     /region_name="ELM2"
                     /note="ELM2 domain; pfam01448"
                     /db_xref="CDD:460214"
     Region          832..876
                     /region_name="SANT"
                     /note="'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains.
                     Tandem copies of the domain bind telomeric DNA tandem
                     repeatsas part of the capping complex. Binding is sequence
                     dependent for repeats which contain the G/C rich motif
                     [C2-3 A (CA)1-6]. The domain is...; cl21498"
                     /db_xref="CDD:473887"
     Site            order(833,862..863,865..866,868..870,872..874)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212559"
     CDS             1..1099
                     /gene="MIDEAS"
                     /gene_synonym="C14orf117; C14orf43; c14_5541; ELMSAN1;
                     LSR68"
                     /coded_by="XM_005268206.1:557..3856"
                     /db_xref="GeneID:91748"
                     /db_xref="HGNC:HGNC:19853"
                     /db_xref="MIM:621074"
ORIGIN      
        1 mnlqaqpkaq nkrkrclfgg qepapkeqpp plqppqqsir vkeeqylghe gpggavstsq
       61 pvelpppssl allnsvvygp ertsaamlsq qvasvkwpns vmapgrgper gggggvsdss
      121 wqqqpgqppp hstwnchsls lysatkgsph pgvgvptyyn hpealkreka ggpqldryvr
      181 pmmpqkvqle vgrpqaplns fhaakkppnq slplqpfqla fghqvnrqvf rqgppppnpv
      241 aafppqkqqq qqqpqqqqqq qqaalpqmpl fenfysmpqq psqqpqdfgl qpagplgqsh
      301 lahhsmapyp fppnpdmnpe lrkallqdsa pqpalpqvqi pfprrsrrls kegilppsal
      361 dgagtqpgqe atgnlflhhw plqqpppgsl gqphpealgf plelresqll pdgerlapng
      421 rereapamgs eegmravstg dcgqvlrggv iqstrrrrra sqeanlltla qkavelaslq
      481 nakdgsgsee krksvlastt kcgvefseps latkrareds gmvpliipvs vpvrtvdpte
      541 aaqagglded gkgpeqnpae hkpsvivtrr rstripgtda qaqaedmnvk legepsvrkp
      601 kqrprpepli iptkagtfia ppvysnitpy qshlrspvrl adhpsersfe lppytpppil
      661 spvregsgly fnaiiststi papppitpks ahrtllrtns aevtppvlsv mgeatpvsie
      721 prinvgsrfq aeiplmrdra laaadphkad lvwqpwedle ssrekqrqve dlltaacssi
      781 fpgagtnqel alhclhesrg diletlnkll lkkplrphnh platyhytgs dqwkmaerkl
      841 fnkgiaiykk dfflvqkliq tktvaqcvef yytykkqvki grngtltfgd vdtsdeksaq
      901 eevevdikts qkfprvplpr respseerle pkrevkeprk egeeevpeiq ekeeqeegre
      961 rsrraaavka tqtlqanesa sdililrshe snapgsaggq asekpregtg ksrralpfse
     1021 kkkktetfsk tqnqentfpc kkcgrvfykv ksrsahmksh aeqekkaaal rlkekeaaaa
     1081 aaaahqqalr eesgagdkg
//
LOCUS       XP_047287871             620 aa            linear   PRI 05-AUG-2025
DEFINITION  mitotic deacetylase-associated SANT domain protein isoform X2 [Homo
            sapiens].
ACCESSION   XP_047287871
VERSION     XP_047287871.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431915.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..620
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..620
                     /product="mitotic deacetylase-associated SANT domain
                     protein isoform X2"
                     /calculated_mol_wt=67222
     CDS             1..620
                     /gene="MIDEAS"
                     /gene_synonym="C14orf117; C14orf43; c14_5541; ELMSAN1;
                     LSR68"
                     /coded_by="XM_047431915.1:789..2651"
                     /db_xref="GeneID:91748"
                     /db_xref="HGNC:HGNC:19853"
                     /db_xref="MIM:621074"
ORIGIN      
        1 mnlqaqpkaq nkrkrclfgg qepapkeqpp plqppqqsir vkeeqylghe gpggavstsq
       61 pvelpppssl allnsvvygp ertsaamlsq qvasvkwpns vmapgrgper gggggvsdss
      121 wqqqpgqppp hstwnchsls lysatkgsph pgvgvptyyn hpealkreka ggpqldryvr
      181 pmmpqkvqle vgrpqaplns fhaakkppnq slplqpfqla fghqvnrqvf rqgppppnpv
      241 aafppqkqqq qqqpqqqqqq qqaalpqmpl fenfysmpqq psqqpqdfgl qpagplgqsh
      301 lahhsmapyp fppnpdmnpe lrkallqdsa pqpalpqvqi pfprrsrrls kegilppsal
      361 dgagtqpgqe atgnlflhhw plqqpppgsl gqphpealgf plelresqll pdgerlapng
      421 rereapamgs eegmravstg dcgqvlrggv iqstrrrrra sqeanlltla qkavelaslq
      481 nakdgsgsee krksvlastt kcgvefseps latkrareds gmvpliipvs vpvrtvdpte
      541 aaqagglded gkgpeqnpae hkpsvivtrr rstripgtda qaqkkfadfc prgddkkgfw
      601 tcsffqaclg gcgrqtkfqr
//
LOCUS       XP_047287872             149 aa            linear   PRI 05-AUG-2025
DEFINITION  protein lin-52 homolog isoform X1 [Homo sapiens].
ACCESSION   XP_047287872
VERSION     XP_047287872.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431916.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..149
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..149
                     /product="protein lin-52 homolog isoform X1"
                     /calculated_mol_wt=16499
     Region          16..96
                     /region_name="LIN52"
                     /note="Retinal tissue protein; pfam10044"
                     /db_xref="CDD:462950"
     CDS             1..149
                     /gene="LIN52"
                     /gene_synonym="C14orf46; c14_5549"
                     /coded_by="XM_047431916.1:8..457"
                     /db_xref="GeneID:91750"
                     /db_xref="HGNC:HGNC:19856"
                     /db_xref="MIM:621288"
ORIGIN      
        1 mgwkmasptd dleasllsfe kldraspdlw peqlpgvaef aasfkspits sppkwmaeie
       61 rddidmlkel gslttanlme kvrglqnlay qlgldewsps vtqagvqwcd lgslqplppg
      121 lkqvphlsfp sswdyrcepq rparnafli
//
LOCUS       XP_011535623             112 aa            linear   PRI 05-AUG-2025
DEFINITION  protein lin-52 homolog isoform X2 [Homo sapiens].
ACCESSION   XP_011535623
VERSION     XP_011535623.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537321.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XP_011535623.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..112
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..112
                     /product="protein lin-52 homolog isoform X2"
                     /calculated_mol_wt=12262
     Region          18..98
                     /region_name="LIN52"
                     /note="Retinal tissue protein; pfam10044"
                     /db_xref="CDD:462950"
     CDS             1..112
                     /gene="LIN52"
                     /gene_synonym="C14orf46; c14_5549"
                     /coded_by="XM_011537321.4:8..346"
                     /db_xref="GeneID:91750"
                     /db_xref="HGNC:HGNC:19856"
                     /db_xref="MIM:621288"
ORIGIN      
        1 mgwkmasptd gtdleaslls fekldraspd lwpeqlpgva efaasfkspi tssppkwmae
       61 ierddidmlk elgslttanl mekvrglqnl ayqlgldeyy sstlgvgfyl tp
//
LOCUS       XP_047287873             110 aa            linear   PRI 05-AUG-2025
DEFINITION  protein lin-52 homolog isoform X3 [Homo sapiens].
ACCESSION   XP_047287873
VERSION     XP_047287873.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431917.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..110
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..110
                     /product="protein lin-52 homolog isoform X3"
                     /calculated_mol_wt=12104
     Region          16..96
                     /region_name="LIN52"
                     /note="Retinal tissue protein; pfam10044"
                     /db_xref="CDD:462950"
     CDS             1..110
                     /gene="LIN52"
                     /gene_synonym="C14orf46; c14_5549"
                     /coded_by="XM_047431917.1:8..340"
                     /db_xref="GeneID:91750"
                     /db_xref="HGNC:HGNC:19856"
                     /db_xref="MIM:621288"
ORIGIN      
        1 mgwkmasptd dleasllsfe kldraspdlw peqlpgvaef aasfkspits sppkwmaeie
       61 rddidmlkel gslttanlme kvrglqnlay qlgldeyyss tlgvgfyltp
//
LOCUS       XP_011535624             108 aa            linear   PRI 05-AUG-2025
DEFINITION  protein lin-52 homolog isoform X4 [Homo sapiens].
ACCESSION   XP_011535624
VERSION     XP_011535624.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537322.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Jun 6, 2016 this sequence version replaced XP_011535624.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..108
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..108
                     /product="protein lin-52 homolog isoform X4"
                     /calculated_mol_wt=11956
     Region          18..98
                     /region_name="LIN52"
                     /note="Retinal tissue protein; pfam10044"
                     /db_xref="CDD:462950"
     CDS             1..108
                     /gene="LIN52"
                     /gene_synonym="C14orf46; c14_5549"
                     /coded_by="XM_011537322.3:8..334"
                     /db_xref="GeneID:91750"
                     /db_xref="HGNC:HGNC:19856"
                     /db_xref="MIM:621288"
ORIGIN      
        1 mgwkmasptd gtdleaslls fekldraspd lwpeqlpgva efaasfkspi tssppkwmae
       61 ierddidmlk elgslttanl mekvrglqnl ayqlgldefg fllprkhf
//
LOCUS       XP_047287874             106 aa            linear   PRI 05-AUG-2025
DEFINITION  protein lin-52 homolog isoform X5 [Homo sapiens].
ACCESSION   XP_047287874
VERSION     XP_047287874.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431918.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..106
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..106
                     /product="protein lin-52 homolog isoform X5"
                     /calculated_mol_wt=11798
     Region          16..96
                     /region_name="LIN52"
                     /note="Retinal tissue protein; pfam10044"
                     /db_xref="CDD:462950"
     CDS             1..106
                     /gene="LIN52"
                     /gene_synonym="C14orf46; c14_5549"
                     /coded_by="XM_047431918.1:8..328"
                     /db_xref="GeneID:91750"
                     /db_xref="HGNC:HGNC:19856"
                     /db_xref="MIM:621288"
ORIGIN      
        1 mgwkmasptd dleasllsfe kldraspdlw peqlpgvaef aasfkspits sppkwmaeie
       61 rddidmlkel gslttanlme kvrglqnlay qlgldefgfl lprkhf
//
LOCUS       XP_016877253              98 aa            linear   PRI 05-AUG-2025
DEFINITION  protein lin-52 homolog isoform X6 [Homo sapiens].
ACCESSION   XP_016877253
VERSION     XP_016877253.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021764.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..98
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..98
                     /product="protein lin-52 homolog isoform X6"
                     /calculated_mol_wt=10712
     Region          18..98
                     /region_name="LIN52"
                     /note="Retinal tissue protein; pfam10044"
                     /db_xref="CDD:462950"
     CDS             1..98
                     /gene="LIN52"
                     /gene_synonym="C14orf46; c14_5549"
                     /coded_by="XM_017021764.2:8..304"
                     /db_xref="GeneID:91750"
                     /db_xref="HGNC:HGNC:19856"
                     /db_xref="MIM:621288"
ORIGIN      
        1 mgwkmasptd gtdleaslls fekldraspd lwpeqlpgva efaasfkspi tssppkwmae
       61 ierddidmlk elgslttanl mekvrglqnl ayqlglde
//
LOCUS       XP_005268266             873 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase Nek9 isoform X1 [Homo sapiens].
ACCESSION   XP_005268266
VERSION     XP_005268266.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005268209.4
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 36% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..873
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..873
                     /product="serine/threonine-protein kinase Nek9 isoform X1"
                     /calculated_mol_wt=95361
     Region          <1..190
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Region          254..645
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     CDS             1..873
                     /gene="NEK9"
                     /gene_synonym="APUG; LCCS10; NC; NERCC; NERCC1"
                     /coded_by="XM_005268209.4:280..2901"
                     /db_xref="GeneID:91754"
                     /db_xref="HGNC:HGNC:18591"
                     /db_xref="MIM:609798"
ORIGIN      
        1 mdnttlliel eycnggnlyd kilrqkdklf eeemvvwylf qivsavscih kagilhrdik
       61 tlnifltkan liklgdygla kklnseysma etlvgtpyym spelcqgvky nfksdiwavg
      121 cvifelltlk rtfdatnpln lcvkivqgir amevdssqys leliqmvhsc ldqdpeqrpt
      181 adelldrpll rkrrremeek vtllnaptkr prsstvteap iavvtsrtse vyvwgggkst
      241 pqkldviksg csarqvcagn thfavvtvek elytwvnmqg gtklhgqlgh gdkasyrqpk
      301 hveklqgkai rqvscgddft vcvtdegqly afgsdyygcm gvdkvagpev lepmqlnffl
      361 snpveqvscg dnhvvvltrn kevyswgcge ygrgslvsvh fftgrlglds eedyytpqkv
      421 dvpkaliiva vqcgcdgtfl ltqsgkvlac glnefnklgl nqcmsgiinh eayhevpytt
      481 sftlakqlsf ykirtiapgk thtaaiderg rlltfgcnkc gqlgvgnykk rlginllggp
      541 lggkqvirvs cgdeftiaat ddnhifawgn ggngrlamtp terphgsdic tswprpifgs
      601 lhhvpdlscr gwhtilivek vlnsktirsn ssglsigtvf qssspggggg ggggeeedsq
      661 qesetpdpsg gfrgtmeadr gmeglispte amgnsngass scpgwlrkel enaefipmpd
      721 spsplsaafs esekdtlpye elqglkvase aplehkpqve assprlnpav tcagkgtplt
      781 ppacacsslq veverlqglv lkclaeqqkl qqenlqiftq lqklnkkleg gqqvgmhskg
      841 tqtakeemem dpkpdldsds wcllgtdscr psl
//
LOCUS       XP_047287875             861 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase Nek9 isoform X2 [Homo sapiens].
ACCESSION   XP_047287875
VERSION     XP_047287875.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431919.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 37% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..861
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..861
                     /product="serine/threonine-protein kinase Nek9 isoform X2"
                     /calculated_mol_wt=94073
     Region          <1..190
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Region          254..633
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     CDS             1..861
                     /gene="NEK9"
                     /gene_synonym="APUG; LCCS10; NC; NERCC; NERCC1"
                     /coded_by="XM_047431919.1:217..2802"
                     /db_xref="GeneID:91754"
                     /db_xref="HGNC:HGNC:18591"
                     /db_xref="MIM:609798"
ORIGIN      
        1 mdnttlliel eycnggnlyd kilrqkdklf eeemvvwylf qivsavscih kagilhrdik
       61 tlnifltkan liklgdygla kklnseysma etlvgtpyym spelcqgvky nfksdiwavg
      121 cvifelltlk rtfdatnpln lcvkivqgir amevdssqys leliqmvhsc ldqdpeqrpt
      181 adelldrpll rkrrremeek vtllnaptkr prsstvteap iavvtsrtse vyvwgggkst
      241 pqkldviksg csarqvcagn thfavvtvek elytwvnmqg gtklhgqlgh gdkasyrqpk
      301 hveklqgkai rqvscgddft vcvtdegqly afgsdyygcm gvdkvagpev lepmqlnffl
      361 snpveqvscg dnhvvvltrn kevyswgcge ygrlgldsee dyytpqkvdv pkaliivavq
      421 cgcdgtfllt qsgkvlacgl nefnklglnq cmsgiinhea yhevpyttsf tlakqlsfyk
      481 irtiapgkth taaidergrl ltfgcnkcgq lgvgnykkrl ginllggplg gkqvirvscg
      541 deftiaatdd nhifawgngg ngrlamtpte rphgsdicts wprpifgslh hvpdlscrgw
      601 htilivekvl nsktirsnss glsigtvfqs sspggggggg ggeeedsqqe setpdpsggf
      661 rgtmeadrgm eglispteam gnsngasssc pgwlrkelen aefipmpdsp splsaafses
      721 ekdtlpyeel qglkvaseap lehkpqveas sprlnpavtc agkgtpltpp acacsslqve
      781 verlqglvlk claeqqklqq enlqiftqlq klnkkleggq qvgmhskgtq takeememdp
      841 kpdldsdswc llgtdscrps l
//
LOCUS       XP_011535625             722 aa            linear   PRI 05-AUG-2025
DEFINITION  exocyst complex component 3-like protein 4 isoform X1 [Homo
            sapiens].
ACCESSION   XP_011535625
VERSION     XP_011535625.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537323.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XP_011535625.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..722
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..722
                     /product="exocyst complex component 3-like protein 4
                     isoform X1"
                     /calculated_mol_wt=79765
     Region          180..709
                     /region_name="Sec6"
                     /note="Exocyst complex component Sec6; pfam06046"
                     /db_xref="CDD:428738"
     CDS             1..722
                     /gene="EXOC3L4"
                     /gene_synonym="C14orf73"
                     /coded_by="XM_011537323.4:126..2294"
                     /db_xref="GeneID:91828"
                     /db_xref="HGNC:HGNC:20120"
                     /db_xref="MIM:621085"
ORIGIN      
        1 mpspqtdtpg pelqspkeae epqtpaqgsr rtssrkepna hrkdgtrlgl gslrqafsra
       61 sqraltqvsk edtglfrrss cslfrsfrqa lndgpatghs qatpevpsgv mngvsqqast
      121 gaaseelkpe aegksvadli terqllaafe qllrletllv aekasrtfeq dptafarram
      181 dvcllydgla aeigaivret ldsdgvdaaa laelarvvsa eeeahpsppd dgdflrtprr
      241 wrqhweeavr rsaqervrrp gagwafgeae gasglaqlla elgglvrrdl qkvrqevqpa
      301 yaaagfpawe vylrafhsav aqrlqelard argceqlyil ldwaanvygs pdflgapgla
      361 lpaeplppll apdvwarles dytsfleaki ascfdsilql eqshwaaaev pevlqglyqa
      421 plsmdvhmlv aehvkaagai saeleattlr ictralglfv prfekaflas eavsephlga
      481 yinaceelrt sllsrfpgtq eelekplvta tcsfqkhllq glqrelqplf rvvctrdwlt
      541 qdwlhplmdk vvtfaghlqr varpraqetl qevhrfvvre ylaralrpre rfrgmermhg
      601 sqkmsldaqa isdtfqglgs eatwldqaiq cvaeilgety kddiqrhlet lirsypdirr
      661 dhilailalr rlgrqrnqhl lqhtqdllra aagaagaeap rgrvlfeeik vpsamavlit
      721 cv
//
LOCUS       XP_011535626             716 aa            linear   PRI 05-AUG-2025
DEFINITION  exocyst complex component 3-like protein 4 isoform X2 [Homo
            sapiens].
ACCESSION   XP_011535626
VERSION     XP_011535626.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537324.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XP_011535626.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..716
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..716
                     /product="exocyst complex component 3-like protein 4
                     isoform X2"
                     /calculated_mol_wt=79107
     Region          180..703
                     /region_name="Sec6"
                     /note="Exocyst complex component Sec6; pfam06046"
                     /db_xref="CDD:428738"
     CDS             1..716
                     /gene="EXOC3L4"
                     /gene_synonym="C14orf73"
                     /coded_by="XM_011537324.3:126..2276"
                     /db_xref="GeneID:91828"
                     /db_xref="HGNC:HGNC:20120"
                     /db_xref="MIM:621085"
ORIGIN      
        1 mpspqtdtpg pelqspkeae epqtpaqgsr rtssrkepna hrkdgtrlgl gslrqafsra
       61 sqraltqvsk edtglfrrss cslfrsfrqa lndgpatghs qatpevpsgv mngvsqqast
      121 gaaseelkpe aegksvadli terqllaafe qllrletllv aekasrtfeq dptafarram
      181 dvcllydgla aeigaivret ldsdgvdaaa laelarvvsa eeeahpsppd dgdflrtprr
      241 wrqhweeavr rsaqervrrp gagwafgeae gasglaqlla elgglvrrdl qkvrqevqpa
      301 yaaagfpawe vylrafhsav aqrlqelard argceqlyil ldwaanvygs pdflgapgla
      361 lpaeplppll apdvwarles dytsfleaki ascfdsilql eqshwaaaev pevlqglyqa
      421 plsmdvhmlv aehvkaagai saeleattlr ictralglfv prfekaflas eavsephlga
      481 yinaceelrf pgtqeelekp lvtatcsfqk hllqglqrel qplfrvvctr dwltqdwlhp
      541 lmdkvvtfag hlqrvarpra qetlqevhrf vvreylaral rprerfrgme rmhgsqkmsl
      601 daqaisdtfq glgseatwld qaiqcvaeil getykddiqr hletlirsyp dirrdhilai
      661 lalrrlgrqr nqhllqhtqd llraaagaag aeaprgrvlf eeikvpsama vlitcv
//
LOCUS       XP_011535635             759 aa            linear   PRI 05-AUG-2025
DEFINITION  exocyst complex component 3-like protein 4 isoform X3 [Homo
            sapiens].
ACCESSION   XP_011535635
VERSION     XP_011535635.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537333.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..759
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..759
                     /product="exocyst complex component 3-like protein 4
                     isoform X3"
                     /calculated_mol_wt=83909
     Region          217..746
                     /region_name="Sec6"
                     /note="Exocyst complex component Sec6; pfam06046"
                     /db_xref="CDD:428738"
     CDS             1..759
                     /gene="EXOC3L4"
                     /gene_synonym="C14orf73"
                     /coded_by="XM_011537333.3:401..2680"
                     /db_xref="GeneID:91828"
                     /db_xref="HGNC:HGNC:20120"
                     /db_xref="MIM:621085"
ORIGIN      
        1 meswsdclrn ekevgtslkv kllsrlwepq gsspaakmps pqtdtpgpel qspkeaeepq
       61 tpaqgsrrts srkepnahrk dgtrlglgsl rqafsrasqr altqvskedt glfrrsscsl
      121 frsfrqalnd gpatghsqat pevpsgvmng vsqqastgaa seelkpeaeg ksvadliter
      181 qllaafeqll rletllvaek asrtfeqdpt afarramdvc llydglaaei gaivretlds
      241 dgvdaaalae larvvsaeee ahpsppddgd flrtprrwrq hweeavrrsa qervrrpgag
      301 wafgeaegas glaqllaelg glvrrdlqkv rqevqpayaa agfpawevyl rafhsavaqr
      361 lqelardarg ceqlyilldw aanvygspdf lgapglalpa eplppllapd vwarlesdyt
      421 sfleakiasc fdsilqleqs hwaaaevpev lqglyqapls mdvhmlvaeh vkaagaisae
      481 leattlrict ralglfvprf ekaflaseav sephlgayin aceelrtsll srfpgtqeel
      541 ekplvtatcs fqkhllqglq relqplfrvv ctrdwltqdw lhplmdkvvt faghlqrvar
      601 praqetlqev hrfvvreyla ralrprerfr gmermhgsqk msldaqaisd tfqglgseat
      661 wldqaiqcva eilgetykdd iqrhletlir sypdirrdhi lailalrrlg rqrnqhllqh
      721 tqdllraaag aagaeaprgr vlfeeikvps amavlitcv
//
LOCUS       XP_011535631             722 aa            linear   PRI 05-AUG-2025
DEFINITION  exocyst complex component 3-like protein 4 isoform X1 [Homo
            sapiens].
ACCESSION   XP_011535631
VERSION     XP_011535631.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537329.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..722
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..722
                     /product="exocyst complex component 3-like protein 4
                     isoform X1"
                     /calculated_mol_wt=79765
     Region          180..709
                     /region_name="Sec6"
                     /note="Exocyst complex component Sec6; pfam06046"
                     /db_xref="CDD:428738"
     CDS             1..722
                     /gene="EXOC3L4"
                     /gene_synonym="C14orf73"
                     /coded_by="XM_011537329.3:650..2818"
                     /db_xref="GeneID:91828"
                     /db_xref="HGNC:HGNC:20120"
                     /db_xref="MIM:621085"
ORIGIN      
        1 mpspqtdtpg pelqspkeae epqtpaqgsr rtssrkepna hrkdgtrlgl gslrqafsra
       61 sqraltqvsk edtglfrrss cslfrsfrqa lndgpatghs qatpevpsgv mngvsqqast
      121 gaaseelkpe aegksvadli terqllaafe qllrletllv aekasrtfeq dptafarram
      181 dvcllydgla aeigaivret ldsdgvdaaa laelarvvsa eeeahpsppd dgdflrtprr
      241 wrqhweeavr rsaqervrrp gagwafgeae gasglaqlla elgglvrrdl qkvrqevqpa
      301 yaaagfpawe vylrafhsav aqrlqelard argceqlyil ldwaanvygs pdflgapgla
      361 lpaeplppll apdvwarles dytsfleaki ascfdsilql eqshwaaaev pevlqglyqa
      421 plsmdvhmlv aehvkaagai saeleattlr ictralglfv prfekaflas eavsephlga
      481 yinaceelrt sllsrfpgtq eelekplvta tcsfqkhllq glqrelqplf rvvctrdwlt
      541 qdwlhplmdk vvtfaghlqr varpraqetl qevhrfvvre ylaralrpre rfrgmermhg
      601 sqkmsldaqa isdtfqglgs eatwldqaiq cvaeilgety kddiqrhlet lirsypdirr
      661 dhilailalr rlgrqrnqhl lqhtqdllra aagaagaeap rgrvlfeeik vpsamavlit
      721 cv
//
LOCUS       XP_011535632             722 aa            linear   PRI 05-AUG-2025
DEFINITION  exocyst complex component 3-like protein 4 isoform X1 [Homo
            sapiens].
ACCESSION   XP_011535632
VERSION     XP_011535632.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537330.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..722
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..722
                     /product="exocyst complex component 3-like protein 4
                     isoform X1"
                     /calculated_mol_wt=79765
     Region          180..709
                     /region_name="Sec6"
                     /note="Exocyst complex component Sec6; pfam06046"
                     /db_xref="CDD:428738"
     CDS             1..722
                     /gene="EXOC3L4"
                     /gene_synonym="C14orf73"
                     /coded_by="XM_011537330.3:354..2522"
                     /db_xref="GeneID:91828"
                     /db_xref="HGNC:HGNC:20120"
                     /db_xref="MIM:621085"
ORIGIN      
        1 mpspqtdtpg pelqspkeae epqtpaqgsr rtssrkepna hrkdgtrlgl gslrqafsra
       61 sqraltqvsk edtglfrrss cslfrsfrqa lndgpatghs qatpevpsgv mngvsqqast
      121 gaaseelkpe aegksvadli terqllaafe qllrletllv aekasrtfeq dptafarram
      181 dvcllydgla aeigaivret ldsdgvdaaa laelarvvsa eeeahpsppd dgdflrtprr
      241 wrqhweeavr rsaqervrrp gagwafgeae gasglaqlla elgglvrrdl qkvrqevqpa
      301 yaaagfpawe vylrafhsav aqrlqelard argceqlyil ldwaanvygs pdflgapgla
      361 lpaeplppll apdvwarles dytsfleaki ascfdsilql eqshwaaaev pevlqglyqa
      421 plsmdvhmlv aehvkaagai saeleattlr ictralglfv prfekaflas eavsephlga
      481 yinaceelrt sllsrfpgtq eelekplvta tcsfqkhllq glqrelqplf rvvctrdwlt
      541 qdwlhplmdk vvtfaghlqr varpraqetl qevhrfvvre ylaralrpre rfrgmermhg
      601 sqkmsldaqa isdtfqglgs eatwldqaiq cvaeilgety kddiqrhlet lirsypdirr
      661 dhilailalr rlgrqrnqhl lqhtqdllra aagaagaeap rgrvlfeeik vpsamavlit
      721 cv
//
LOCUS       XP_011535633             722 aa            linear   PRI 05-AUG-2025
DEFINITION  exocyst complex component 3-like protein 4 isoform X1 [Homo
            sapiens].
ACCESSION   XP_011535633
VERSION     XP_011535633.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537331.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..722
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..722
                     /product="exocyst complex component 3-like protein 4
                     isoform X1"
                     /calculated_mol_wt=79765
     Region          180..709
                     /region_name="Sec6"
                     /note="Exocyst complex component Sec6; pfam06046"
                     /db_xref="CDD:428738"
     CDS             1..722
                     /gene="EXOC3L4"
                     /gene_synonym="C14orf73"
                     /coded_by="XM_011537331.2:223..2391"
                     /db_xref="GeneID:91828"
                     /db_xref="HGNC:HGNC:20120"
                     /db_xref="MIM:621085"
ORIGIN      
        1 mpspqtdtpg pelqspkeae epqtpaqgsr rtssrkepna hrkdgtrlgl gslrqafsra
       61 sqraltqvsk edtglfrrss cslfrsfrqa lndgpatghs qatpevpsgv mngvsqqast
      121 gaaseelkpe aegksvadli terqllaafe qllrletllv aekasrtfeq dptafarram
      181 dvcllydgla aeigaivret ldsdgvdaaa laelarvvsa eeeahpsppd dgdflrtprr
      241 wrqhweeavr rsaqervrrp gagwafgeae gasglaqlla elgglvrrdl qkvrqevqpa
      301 yaaagfpawe vylrafhsav aqrlqelard argceqlyil ldwaanvygs pdflgapgla
      361 lpaeplppll apdvwarles dytsfleaki ascfdsilql eqshwaaaev pevlqglyqa
      421 plsmdvhmlv aehvkaagai saeleattlr ictralglfv prfekaflas eavsephlga
      481 yinaceelrt sllsrfpgtq eelekplvta tcsfqkhllq glqrelqplf rvvctrdwlt
      541 qdwlhplmdk vvtfaghlqr varpraqetl qevhrfvvre ylaralrpre rfrgmermhg
      601 sqkmsldaqa isdtfqglgs eatwldqaiq cvaeilgety kddiqrhlet lirsypdirr
      661 dhilailalr rlgrqrnqhl lqhtqdllra aagaagaeap rgrvlfeeik vpsamavlit
      721 cv
//
LOCUS       XP_011535634             722 aa            linear   PRI 05-AUG-2025
DEFINITION  exocyst complex component 3-like protein 4 isoform X1 [Homo
            sapiens].
ACCESSION   XP_011535634
VERSION     XP_011535634.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537332.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..722
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..722
                     /product="exocyst complex component 3-like protein 4
                     isoform X1"
                     /calculated_mol_wt=79765
     Region          180..709
                     /region_name="Sec6"
                     /note="Exocyst complex component Sec6; pfam06046"
                     /db_xref="CDD:428738"
     CDS             1..722
                     /gene="EXOC3L4"
                     /gene_synonym="C14orf73"
                     /coded_by="XM_011537332.3:480..2648"
                     /db_xref="GeneID:91828"
                     /db_xref="HGNC:HGNC:20120"
                     /db_xref="MIM:621085"
ORIGIN      
        1 mpspqtdtpg pelqspkeae epqtpaqgsr rtssrkepna hrkdgtrlgl gslrqafsra
       61 sqraltqvsk edtglfrrss cslfrsfrqa lndgpatghs qatpevpsgv mngvsqqast
      121 gaaseelkpe aegksvadli terqllaafe qllrletllv aekasrtfeq dptafarram
      181 dvcllydgla aeigaivret ldsdgvdaaa laelarvvsa eeeahpsppd dgdflrtprr
      241 wrqhweeavr rsaqervrrp gagwafgeae gasglaqlla elgglvrrdl qkvrqevqpa
      301 yaaagfpawe vylrafhsav aqrlqelard argceqlyil ldwaanvygs pdflgapgla
      361 lpaeplppll apdvwarles dytsfleaki ascfdsilql eqshwaaaev pevlqglyqa
      421 plsmdvhmlv aehvkaagai saeleattlr ictralglfv prfekaflas eavsephlga
      481 yinaceelrt sllsrfpgtq eelekplvta tcsfqkhllq glqrelqplf rvvctrdwlt
      541 qdwlhplmdk vvtfaghlqr varpraqetl qevhrfvvre ylaralrpre rfrgmermhg
      601 sqkmsldaqa isdtfqglgs eatwldqaiq cvaeilgety kddiqrhlet lirsypdirr
      661 dhilailalr rlgrqrnqhl lqhtqdllra aagaagaeap rgrvlfeeik vpsamavlit
      721 cv
//
LOCUS       XP_011535636             543 aa            linear   PRI 05-AUG-2025
DEFINITION  exocyst complex component 3-like protein 4 isoform X4 [Homo
            sapiens].
ACCESSION   XP_011535636
VERSION     XP_011535636.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537334.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..543
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..543
                     /product="exocyst complex component 3-like protein 4
                     isoform X4"
                     /calculated_mol_wt=60421
     Region          1..530
                     /region_name="Sec6"
                     /note="Exocyst complex component Sec6; pfam06046"
                     /db_xref="CDD:428738"
     CDS             1..543
                     /gene="EXOC3L4"
                     /gene_synonym="C14orf73"
                     /coded_by="XM_011537334.2:972..2603"
                     /db_xref="GeneID:91828"
                     /db_xref="HGNC:HGNC:20120"
                     /db_xref="MIM:621085"
ORIGIN      
        1 mdvcllydgl aaeigaivre tldsdgvdaa alaelarvvs aeeeahpspp ddgdflrtpr
       61 rwrqhweeav rrsaqervrr pgagwafgea egasglaqll aelgglvrrd lqkvrqevqp
      121 ayaaagfpaw evylrafhsa vaqrlqelar dargceqlyi lldwaanvyg spdflgapgl
      181 alpaeplppl lapdvwarle sdytsfleak iascfdsilq leqshwaaae vpevlqglyq
      241 aplsmdvhml vaehvkaaga isaeleattl rictralglf vprfekafla seavsephlg
      301 ayinaceelr tsllsrfpgt qeelekplvt atcsfqkhll qglqrelqpl frvvctrdwl
      361 tqdwlhplmd kvvtfaghlq rvarpraqet lqevhrfvvr eylaralrpr erfrgmermh
      421 gsqkmsldaq aisdtfqglg seatwldqai qcvaeilget ykddiqrhle tlirsypdir
      481 rdhilailal rrlgrqrnqh llqhtqdllr aaagaagaea prgrvlfeei kvpsamavli
      541 tcv
//
LOCUS       XP_047287877             537 aa            linear   PRI 05-AUG-2025
DEFINITION  exocyst complex component 3-like protein 4 isoform X5 [Homo
            sapiens].
ACCESSION   XP_047287877
VERSION     XP_047287877.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431921.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..537
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..537
                     /product="exocyst complex component 3-like protein 4
                     isoform X5"
                     /calculated_mol_wt=59764
     Region          1..524
                     /region_name="Sec6"
                     /note="Exocyst complex component Sec6; cl19885"
                     /db_xref="CDD:450399"
     CDS             1..537
                     /gene="EXOC3L4"
                     /gene_synonym="C14orf73"
                     /coded_by="XM_047431921.1:1114..2727"
                     /db_xref="GeneID:91828"
                     /db_xref="HGNC:HGNC:20120"
                     /db_xref="MIM:621085"
ORIGIN      
        1 mdvcllydgl aaeigaivre tldsdgvdaa alaelarvvs aeeeahpspp ddgdflrtpr
       61 rwrqhweeav rrsaqervrr pgagwafgea egasglaqll aelgglvrrd lqkvrqevqp
      121 ayaaagfpaw evylrafhsa vaqrlqelar dargceqlyi lldwaanvyg spdflgapgl
      181 alpaeplppl lapdvwarle sdytsfleak iascfdsilq leqshwaaae vpevlqglyq
      241 aplsmdvhml vaehvkaaga isaeleattl rictralglf vprfekafla seavsephlg
      301 ayinaceelr fpgtqeelek plvtatcsfq khllqglqre lqplfrvvct rdwltqdwlh
      361 plmdkvvtfa ghlqrvarpr aqetlqevhr fvvreylara lrprerfrgm ermhgsqkms
      421 ldaqaisdtf qglgseatwl dqaiqcvaei lgetykddiq rhletlirsy pdirrdhila
      481 ilalrrlgrq rnqhllqhtq dllraaagaa gaeaprgrvl feeikvpsam avlitcv
//
LOCUS       XP_047287878             429 aa            linear   PRI 05-AUG-2025
DEFINITION  exocyst complex component 3-like protein 4 isoform X6 [Homo
            sapiens].
ACCESSION   XP_047287878
VERSION     XP_047287878.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431922.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..429
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..429
                     /product="exocyst complex component 3-like protein 4
                     isoform X6"
                     /calculated_mol_wt=46625
     Region          180..>428
                     /region_name="Sec6"
                     /note="Exocyst complex component Sec6; cl19885"
                     /db_xref="CDD:450399"
     CDS             1..429
                     /gene="EXOC3L4"
                     /gene_synonym="C14orf73"
                     /coded_by="XM_047431922.1:126..1415"
                     /db_xref="GeneID:91828"
                     /db_xref="HGNC:HGNC:20120"
                     /db_xref="MIM:621085"
ORIGIN      
        1 mpspqtdtpg pelqspkeae epqtpaqgsr rtssrkepna hrkdgtrlgl gslrqafsra
       61 sqraltqvsk edtglfrrss cslfrsfrqa lndgpatghs qatpevpsgv mngvsqqast
      121 gaaseelkpe aegksvadli terqllaafe qllrletllv aekasrtfeq dptafarram
      181 dvcllydgla aeigaivret ldsdgvdaaa laelarvvsa eeeahpsppd dgdflrtprr
      241 wrqhweeavr rsaqervrrp gagwafgeae gasglaqlla elgglvrrdl qkvrqevqpa
      301 yaaagfpawe vylrafhsav aqrlqelard argceqlyil ldwaanvygs pdflgapgla
      361 lpaeplppll apdvwarles dytsfleaki ascfdsilql eqshwaaaev pevlqglyqa
      421 plsmdvhmv
//
LOCUS       XP_011535637             634 aa            linear   PRI 05-AUG-2025
DEFINITION  WD repeat-containing protein 20 isoform X1 [Homo sapiens].
ACCESSION   XP_011535637
VERSION     XP_011535637.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537335.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..634
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..634
                     /product="WD repeat-containing protein 20 isoform X1"
                     /calculated_mol_wt=69936
     Region          196..261
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          <251..357
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          266..302
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          309..342
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..634
                     /gene="WDR20"
                     /gene_synonym="Bun107; DMR"
                     /coded_by="XM_011537335.3:28..1932"
                     /db_xref="GeneID:91833"
                     /db_xref="HGNC:HGNC:19667"
                     /db_xref="MIM:617741"
ORIGIN      
        1 mategggkem neiktqfttr eglykllphs eysrpnrvpf nsqgsnpvrv sfvnlndqsg
       61 ngdrlcfnvg relyfyiykg vrkvptrasp epasgaadls kpidkriykg tqptchdfnh
      121 ltataesvsl lvgfsagqvq lidpikkets klfneenscq hlwkvdwnee rqnegsktse
      181 ealvtvqrli dksrvtcvkw vpgseslflv ahssgnmyly nvehtcgtta phyqllkqge
      241 sfavhtcksk strnpllkwt vgegalnefa fspdgkflac vsqdgflrvf nfdsvelhgt
      301 mksyfggllc vcwspdgkyi vtggeddlvt vwsfvdcrvi arghghkswv svvafdpytt
      361 sveegdpmef sgsdedfqdl lhfgrdrans tqsrlskrns tdsrpvsvty rfgsvgqdtq
      421 lclwdltedi lfphqplsra rthtnvmnat sppagsngns vttpgnsvpp plprsnslph
      481 savsnagsks svmdgaiasg vskfatlslh drkerhhekd hkrnhsmghi sskssdklnl
      541 vtktktdpak tlgtplcprm edvpllepli ckkiaherlt vlifledciv tacqegfict
      601 wgrpgkvgsq rkstpidseq gqlphsvcfl slsr
//
LOCUS       XP_011535638             627 aa            linear   PRI 05-AUG-2025
DEFINITION  WD repeat-containing protein 20 isoform X2 [Homo sapiens].
ACCESSION   XP_011535638
VERSION     XP_011535638.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537336.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..627
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..627
                     /product="WD repeat-containing protein 20 isoform X2"
                     /calculated_mol_wt=69379
     Region          196..261
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          <251..357
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          266..302
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          309..342
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..627
                     /gene="WDR20"
                     /gene_synonym="Bun107; DMR"
                     /coded_by="XM_011537336.3:28..1911"
                     /db_xref="GeneID:91833"
                     /db_xref="HGNC:HGNC:19667"
                     /db_xref="MIM:617741"
ORIGIN      
        1 mategggkem neiktqfttr eglykllphs eysrpnrvpf nsqgsnpvrv sfvnlndqsg
       61 ngdrlcfnvg relyfyiykg vrkvptrasp epasgaadls kpidkriykg tqptchdfnh
      121 ltataesvsl lvgfsagqvq lidpikkets klfneenscq hlwkvdwnee rqnegsktse
      181 ealvtvqrli dksrvtcvkw vpgseslflv ahssgnmyly nvehtcgtta phyqllkqge
      241 sfavhtcksk strnpllkwt vgegalnefa fspdgkflac vsqdgflrvf nfdsvelhgt
      301 mksyfggllc vcwspdgkyi vtggeddlvt vwsfvdcrvi arghghkswv svvafdpytt
      361 sveegdpmef sgsdedfqdl lhfgrdrans tqsrlskrns tdsrpvsvty rfgsvgqdtq
      421 lclwdltedi lfphqplsra rthtnvmnat sppagsngns vttpgnsvpp plprsnslph
      481 savsnagsks svmdgaiasg vskfatlslh drkerhhekd hkrnhsmghi sskssdklnl
      541 vtktktdpak tlgtplcprm edvpllepli ckkiaherlt vlifledciv tacqegfict
      601 wgrpgkvpae hfcrqedrmq gvlqdqn
//
LOCUS       XP_011535639             624 aa            linear   PRI 05-AUG-2025
DEFINITION  WD repeat-containing protein 20 isoform X3 [Homo sapiens].
ACCESSION   XP_011535639
VERSION     XP_011535639.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537337.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..624
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..624
                     /product="WD repeat-containing protein 20 isoform X3"
                     /calculated_mol_wt=68495
     Region          196..261
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          <251..357
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          266..302
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          309..342
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..624
                     /gene="WDR20"
                     /gene_synonym="Bun107; DMR"
                     /coded_by="XM_011537337.3:28..1902"
                     /db_xref="GeneID:91833"
                     /db_xref="HGNC:HGNC:19667"
                     /db_xref="MIM:617741"
ORIGIN      
        1 mategggkem neiktqfttr eglykllphs eysrpnrvpf nsqgsnpvrv sfvnlndqsg
       61 ngdrlcfnvg relyfyiykg vrkvptrasp epasgaadls kpidkriykg tqptchdfnh
      121 ltataesvsl lvgfsagqvq lidpikkets klfneenscq hlwkvdwnee rqnegsktse
      181 ealvtvqrli dksrvtcvkw vpgseslflv ahssgnmyly nvehtcgtta phyqllkqge
      241 sfavhtcksk strnpllkwt vgegalnefa fspdgkflac vsqdgflrvf nfdsvelhgt
      301 mksyfggllc vcwspdgkyi vtggeddlvt vwsfvdcrvi arghghkswv svvafdpytt
      361 sveegdpmef sgsdedfqdl lhfgrdrans tqsrlskrns tdsrpvsvty rfgsvgqdtq
      421 lclwdltedi lfphqplsra rthtnvmnat sppagsngns vttpgnsvpp plprsnslph
      481 savsnagsks svmdgaiasg vskfatlslh drkerhhekd hkrnhsmghi sskssdklnl
      541 vtktktdpak tlgtplcprm edvpllepli ckkiaherlt vlifledciv tacqegfict
      601 wgrpgkvgsl sspsqasspg gtvv
//
LOCUS       XP_011535640             622 aa            linear   PRI 05-AUG-2025
DEFINITION  WD repeat-containing protein 20 isoform X4 [Homo sapiens].
ACCESSION   XP_011535640
VERSION     XP_011535640.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537338.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..622
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..622
                     /product="WD repeat-containing protein 20 isoform X4"
                     /calculated_mol_wt=68786
     Region          184..249
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          <239..345
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          254..290
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          297..330
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..622
                     /gene="WDR20"
                     /gene_synonym="Bun107; DMR"
                     /coded_by="XM_011537338.2:28..1896"
                     /db_xref="GeneID:91833"
                     /db_xref="HGNC:HGNC:19667"
                     /db_xref="MIM:617741"
ORIGIN      
        1 mategggkem neiktqfttr eglykllphs eysrpnrvpf nsqgsnpvrv sfvnlndqsg
       61 ngdrlcfnvg relyfyiykg vrkaadlskp idkriykgtq ptchdfnhlt ataesvsllv
      121 gfsagqvqli dpikketskl fneenscqhl wkvdwneerq negsktseea lvtvqrlidk
      181 srvtcvkwvp gseslflvah ssgnmylynv ehtcgttaph yqllkqgesf avhtckskst
      241 rnpllkwtvg egalnefafs pdgkflacvs qdgflrvfnf dsvelhgtmk syfggllcvc
      301 wspdgkyivt ggeddlvtvw sfvdcrviar ghghkswvsv vafdpyttsv eegdpmefsg
      361 sdedfqdllh fgrdranstq srlskrnstd srpvsvtyrf gsvgqdtqlc lwdltedilf
      421 phqplsrart htnvmnatsp pagsngnsvt tpgnsvpppl prsnslphsa vsnagskssv
      481 mdgaiasgvs kfatlslhdr kerhhekdhk rnhsmghiss kssdklnlvt ktktdpaktl
      541 gtplcprmed vplleplick kiaherltvl ifledcivta cqegfictwg rpgkvgsqrk
      601 stpidseqgq lphsvcflsl sr
//
LOCUS       XP_011535641             620 aa            linear   PRI 05-AUG-2025
DEFINITION  WD repeat-containing protein 20 isoform X5 [Homo sapiens].
ACCESSION   XP_011535641
VERSION     XP_011535641.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537339.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..620
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..620
                     /product="WD repeat-containing protein 20 isoform X5"
                     /calculated_mol_wt=68469
     Region          196..261
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          <251..357
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          266..302
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          309..342
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..620
                     /gene="WDR20"
                     /gene_synonym="Bun107; DMR"
                     /coded_by="XM_011537339.3:28..1890"
                     /db_xref="GeneID:91833"
                     /db_xref="HGNC:HGNC:19667"
                     /db_xref="MIM:617741"
ORIGIN      
        1 mategggkem neiktqfttr eglykllphs eysrpnrvpf nsqgsnpvrv sfvnlndqsg
       61 ngdrlcfnvg relyfyiykg vrkvptrasp epasgaadls kpidkriykg tqptchdfnh
      121 ltataesvsl lvgfsagqvq lidpikkets klfneenscq hlwkvdwnee rqnegsktse
      181 ealvtvqrli dksrvtcvkw vpgseslflv ahssgnmyly nvehtcgtta phyqllkqge
      241 sfavhtcksk strnpllkwt vgegalnefa fspdgkflac vsqdgflrvf nfdsvelhgt
      301 mksyfggllc vcwspdgkyi vtggeddlvt vwsfvdcrvi arghghkswv svvafdpytt
      361 sveegdpmef sgsdedfqdl lhfgrdrans tqsrlskrns tdsrpvsvty rfgsvgqdtq
      421 lclwdltedi lfphqplsra rthtnvmnat sppagsngns vttpgnsvpp plprsnslph
      481 savsnagsks svmdgaiasg vskfatlslh drkerhhekd hkrnhsmghi sskssdklnl
      541 vtktktdpak tlgtplcprm edvpllepli ckkiaherlt vlifledciv tacqegfict
      601 wgrpgkvafe gryatfspfv
//
LOCUS       XP_016877274             615 aa            linear   PRI 05-AUG-2025
DEFINITION  WD repeat-containing protein 20 isoform X6 [Homo sapiens].
ACCESSION   XP_016877274
VERSION     XP_016877274.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021785.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..615
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..615
                     /product="WD repeat-containing protein 20 isoform X6"
                     /calculated_mol_wt=68229
     Region          184..249
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          <239..345
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          254..290
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          297..330
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..615
                     /gene="WDR20"
                     /gene_synonym="Bun107; DMR"
                     /coded_by="XM_017021785.2:28..1875"
                     /db_xref="GeneID:91833"
                     /db_xref="HGNC:HGNC:19667"
                     /db_xref="MIM:617741"
ORIGIN      
        1 mategggkem neiktqfttr eglykllphs eysrpnrvpf nsqgsnpvrv sfvnlndqsg
       61 ngdrlcfnvg relyfyiykg vrkaadlskp idkriykgtq ptchdfnhlt ataesvsllv
      121 gfsagqvqli dpikketskl fneenscqhl wkvdwneerq negsktseea lvtvqrlidk
      181 srvtcvkwvp gseslflvah ssgnmylynv ehtcgttaph yqllkqgesf avhtckskst
      241 rnpllkwtvg egalnefafs pdgkflacvs qdgflrvfnf dsvelhgtmk syfggllcvc
      301 wspdgkyivt ggeddlvtvw sfvdcrviar ghghkswvsv vafdpyttsv eegdpmefsg
      361 sdedfqdllh fgrdranstq srlskrnstd srpvsvtyrf gsvgqdtqlc lwdltedilf
      421 phqplsrart htnvmnatsp pagsngnsvt tpgnsvpppl prsnslphsa vsnagskssv
      481 mdgaiasgvs kfatlslhdr kerhhekdhk rnhsmghiss kssdklnlvt ktktdpaktl
      541 gtplcprmed vplleplick kiaherltvl ifledcivta cqegfictwg rpgkvpaehf
      601 crqedrmqgv lqdqn
//
LOCUS       XP_011535642             615 aa            linear   PRI 05-AUG-2025
DEFINITION  WD repeat-containing protein 20 isoform X7 [Homo sapiens].
ACCESSION   XP_011535642
VERSION     XP_011535642.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537340.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..615
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..615
                     /product="WD repeat-containing protein 20 isoform X7"
                     /calculated_mol_wt=67887
     Region          196..261
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          <251..357
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          266..302
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          309..342
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..615
                     /gene="WDR20"
                     /gene_synonym="Bun107; DMR"
                     /coded_by="XM_011537340.4:28..1875"
                     /db_xref="GeneID:91833"
                     /db_xref="HGNC:HGNC:19667"
                     /db_xref="MIM:617741"
ORIGIN      
        1 mategggkem neiktqfttr eglykllphs eysrpnrvpf nsqgsnpvrv sfvnlndqsg
       61 ngdrlcfnvg relyfyiykg vrkvptrasp epasgaadls kpidkriykg tqptchdfnh
      121 ltataesvsl lvgfsagqvq lidpikkets klfneenscq hlwkvdwnee rqnegsktse
      181 ealvtvqrli dksrvtcvkw vpgseslflv ahssgnmyly nvehtcgtta phyqllkqge
      241 sfavhtcksk strnpllkwt vgegalnefa fspdgkflac vsqdgflrvf nfdsvelhgt
      301 mksyfggllc vcwspdgkyi vtggeddlvt vwsfvdcrvi arghghkswv svvafdpytt
      361 sveegdpmef sgsdedfqdl lhfgrdrans tqsrlskrns tdsrpvsvty rfgsvgqdtq
      421 lclwdltedi lfphqplsra rthtnvmnat sppagsngns vttpgnsvpp plprsnslph
      481 savsnagsks svmdgaiasg vskfatlslh drkerhhekd hkrnhsmghi sskssdklnl
      541 vtktktdpak tlgtplcprm edvpllepli ckkiaherlt vlifledciv tacqegfict
      601 wgrpgkvllp chchs
//
LOCUS       XP_011535643             603 aa            linear   PRI 05-AUG-2025
DEFINITION  WD repeat-containing protein 20 isoform X8 [Homo sapiens].
ACCESSION   XP_011535643
VERSION     XP_011535643.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537341.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..603
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..603
                     /product="WD repeat-containing protein 20 isoform X8"
                     /calculated_mol_wt=66308
     Region          114..155
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          165..230
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          <220..326
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          235..271
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          278..311
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..603
                     /gene="WDR20"
                     /gene_synonym="Bun107; DMR"
                     /coded_by="XM_011537341.3:28..1839"
                     /db_xref="GeneID:91833"
                     /db_xref="HGNC:HGNC:19667"
                     /db_xref="MIM:617741"
ORIGIN      
        1 mategggkem neiktqfttr eglykllphs eysrpnrvpf nsqgsnpvrv sfvnlndqsg
       61 ngdrlcfnvg relyfyiykg vrkvptrasp epasgaadls kpidkriykg tqptchdfnh
      121 ltataesvsl lvgfsagqvq lidpikkets klfneerlid ksrvtcvkwv pgseslflva
      181 hssgnmylyn vehtcgttap hyqllkqges favhtcksks trnpllkwtv gegalnefaf
      241 spdgkflacv sqdgflrvfn fdsvelhgtm ksyfggllcv cwspdgkyiv tggeddlvtv
      301 wsfvdcrvia rghghkswvs vvafdpytts veegdpmefs gsdedfqdll hfgrdranst
      361 qsrlskrnst dsrpvsvtyr fgsvgqdtql clwdltedil fphqplsrar thtnvmnats
      421 ppagsngnsv ttpgnsvppp lprsnslphs avsnagskss vmdgaiasgv skfatlslhd
      481 rkerhhekdh krnhsmghis skssdklnlv tktktdpakt lgtplcprme dvplleplic
      541 kkiaherltv lifledcivt acqegfictw grpgkvgsqr kstpidseqg qlphsvcfls
      601 lsr
//
LOCUS       XP_047287880             596 aa            linear   PRI 05-AUG-2025
DEFINITION  WD repeat-containing protein 20 isoform X9 [Homo sapiens].
ACCESSION   XP_047287880
VERSION     XP_047287880.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431924.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..596
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..596
                     /product="WD repeat-containing protein 20 isoform X9"
                     /calculated_mol_wt=65751
     Region          114..155
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          165..230
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          <220..326
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          235..271
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          278..311
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..596
                     /gene="WDR20"
                     /gene_synonym="Bun107; DMR"
                     /coded_by="XM_047431924.1:28..1818"
                     /db_xref="GeneID:91833"
                     /db_xref="HGNC:HGNC:19667"
                     /db_xref="MIM:617741"
ORIGIN      
        1 mategggkem neiktqfttr eglykllphs eysrpnrvpf nsqgsnpvrv sfvnlndqsg
       61 ngdrlcfnvg relyfyiykg vrkvptrasp epasgaadls kpidkriykg tqptchdfnh
      121 ltataesvsl lvgfsagqvq lidpikkets klfneerlid ksrvtcvkwv pgseslflva
      181 hssgnmylyn vehtcgttap hyqllkqges favhtcksks trnpllkwtv gegalnefaf
      241 spdgkflacv sqdgflrvfn fdsvelhgtm ksyfggllcv cwspdgkyiv tggeddlvtv
      301 wsfvdcrvia rghghkswvs vvafdpytts veegdpmefs gsdedfqdll hfgrdranst
      361 qsrlskrnst dsrpvsvtyr fgsvgqdtql clwdltedil fphqplsrar thtnvmnats
      421 ppagsngnsv ttpgnsvppp lprsnslphs avsnagskss vmdgaiasgv skfatlslhd
      481 rkerhhekdh krnhsmghis skssdklnlv tktktdpakt lgtplcprme dvplleplic
      541 kkiaherltv lifledcivt acqegfictw grpgkvpaeh fcrqedrmqg vlqdqn
//
LOCUS       XP_016877256             593 aa            linear   PRI 05-AUG-2025
DEFINITION  WD repeat-containing protein 20 isoform X10 [Homo sapiens].
ACCESSION   XP_016877256
VERSION     XP_016877256.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021767.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..593
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..593
                     /product="WD repeat-containing protein 20 isoform X10"
                     /calculated_mol_wt=64867
     Region          114..155
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          165..230
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          <220..326
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          235..271
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          278..311
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..593
                     /gene="WDR20"
                     /gene_synonym="Bun107; DMR"
                     /coded_by="XM_017021767.2:28..1809"
                     /db_xref="GeneID:91833"
                     /db_xref="HGNC:HGNC:19667"
                     /db_xref="MIM:617741"
ORIGIN      
        1 mategggkem neiktqfttr eglykllphs eysrpnrvpf nsqgsnpvrv sfvnlndqsg
       61 ngdrlcfnvg relyfyiykg vrkvptrasp epasgaadls kpidkriykg tqptchdfnh
      121 ltataesvsl lvgfsagqvq lidpikkets klfneerlid ksrvtcvkwv pgseslflva
      181 hssgnmylyn vehtcgttap hyqllkqges favhtcksks trnpllkwtv gegalnefaf
      241 spdgkflacv sqdgflrvfn fdsvelhgtm ksyfggllcv cwspdgkyiv tggeddlvtv
      301 wsfvdcrvia rghghkswvs vvafdpytts veegdpmefs gsdedfqdll hfgrdranst
      361 qsrlskrnst dsrpvsvtyr fgsvgqdtql clwdltedil fphqplsrar thtnvmnats
      421 ppagsngnsv ttpgnsvppp lprsnslphs avsnagskss vmdgaiasgv skfatlslhd
      481 rkerhhekdh krnhsmghis skssdklnlv tktktdpakt lgtplcprme dvplleplic
      541 kkiaherltv lifledcivt acqegfictw grpgkvgsls spsqasspgg tvv
//
LOCUS       XP_011535645             572 aa            linear   PRI 05-AUG-2025
DEFINITION  WD repeat-containing protein 20 isoform X11 [Homo sapiens].
ACCESSION   XP_011535645
VERSION     XP_011535645.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537343.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..572
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..572
                     /product="WD repeat-containing protein 20 isoform X11"
                     /calculated_mol_wt=62841
     Region          134..199
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          <189..295
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          204..240
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          247..280
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..572
                     /gene="WDR20"
                     /gene_synonym="Bun107; DMR"
                     /coded_by="XM_011537343.2:230..1948"
                     /db_xref="GeneID:91833"
                     /db_xref="HGNC:HGNC:19667"
                     /db_xref="MIM:617741"
ORIGIN      
        1 mwagsctsis trgsarqshe vgrteilisv lteaadlskp idkriykgtq ptchdfnhlt
       61 ataesvsllv gfsagqvqli dpikketskl fneenscqhl wkvdwneerq negsktseea
      121 lvtvqrlidk srvtcvkwvp gseslflvah ssgnmylynv ehtcgttaph yqllkqgesf
      181 avhtckskst rnpllkwtvg egalnefafs pdgkflacvs qdgflrvfnf dsvelhgtmk
      241 syfggllcvc wspdgkyivt ggeddlvtvw sfvdcrviar ghghkswvsv vafdpyttsv
      301 eegdpmefsg sdedfqdllh fgrdranstq srlskrnstd srpvsvtyrf gsvgqdtqlc
      361 lwdltedilf phqplsrart htnvmnatsp pagsngnsvt tpgnsvpppl prsnslphsa
      421 vsnagskssv mdgaiasgvs kfatlslhdr kerhhekdhk rnhsmghiss kssdklnlvt
      481 ktktdpaktl gtplcprmed vplleplick kiaherltvl ifledcivta cqegfictwg
      541 rpgkvgsqrk stpidseqgq lphsvcflsl sr
//
LOCUS       XP_011535646             541 aa            linear   PRI 05-AUG-2025
DEFINITION  WD repeat-containing protein 20 isoform X12 [Homo sapiens].
ACCESSION   XP_011535646
VERSION     XP_011535646.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537344.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..541
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..541
                     /product="WD repeat-containing protein 20 isoform X12"
                     /calculated_mol_wt=59213
     Region          103..168
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          <158..264
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          173..209
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          216..249
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..541
                     /gene="WDR20"
                     /gene_synonym="Bun107; DMR"
                     /coded_by="XM_011537344.4:230..1855"
                     /db_xref="GeneID:91833"
                     /db_xref="HGNC:HGNC:19667"
                     /db_xref="MIM:617741"
ORIGIN      
        1 mwagsctsis trgsarqshe vgrteilisv lteaadlskp idkriykgtq ptchdfnhlt
       61 ataesvsllv gfsagqvqli dpikketskl fneerlidks rvtcvkwvpg seslflvahs
      121 sgnmylynve htcgttaphy qllkqgesfa vhtckskstr npllkwtvge galnefafsp
      181 dgkflacvsq dgflrvfnfd svelhgtmks yfggllcvcw spdgkyivtg geddlvtvws
      241 fvdcrviarg hghkswvsvv afdpyttsve egdpmefsgs dedfqdllhf grdranstqs
      301 rlskrnstds rpvsvtyrfg svgqdtqlcl wdltedilfp hqplsrarth tnvmnatspp
      361 agsngnsvtt pgnsvppplp rsnslphsav snagskssvm dgaiasgvsk fatlslhdrk
      421 erhhekdhkr nhsmghissk ssdklnlvtk tktdpaktlg tplcprmedv plleplickk
      481 iaherltvli fledcivtac qegfictwgr pgkvgsqrks tpidseqgql phsvcflsls
      541 r
//
LOCUS       XP_006720371             530 aa            linear   PRI 05-AUG-2025
DEFINITION  WD repeat-containing protein 20 isoform X13 [Homo sapiens].
ACCESSION   XP_006720371
VERSION     XP_006720371.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720308.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..530
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..530
                     /product="WD repeat-containing protein 20 isoform X13"
                     /calculated_mol_wt=58473
     Region          92..157
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          <147..253
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          162..198
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          205..238
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..530
                     /gene="WDR20"
                     /gene_synonym="Bun107; DMR"
                     /coded_by="XM_006720308.2:28..1620"
                     /db_xref="GeneID:91833"
                     /db_xref="HGNC:HGNC:19667"
                     /db_xref="MIM:617741"
ORIGIN      
        1 mategggkem neiktqfttr eglykllphs eysrpnrvpf nsqgsnpvrv sfvnlndqsg
       61 ngdrlcfnvg relyfyiykg vrkrlidksr vtcvkwvpgs eslflvahss gnmylynveh
      121 tcgttaphyq llkqgesfav htckskstrn pllkwtvgeg alnefafspd gkflacvsqd
      181 gflrvfnfds velhgtmksy fggllcvcws pdgkyivtgg eddlvtvwsf vdcrviargh
      241 ghkswvsvva fdpyttsvee gdpmefsgsd edfqdllhfg rdranstqsr lskrnstdsr
      301 pvsvtyrfgs vgqdtqlclw dltedilfph qplsrartht nvmnatsppa gsngnsvttp
      361 gnsvppplpr snslphsavs nagskssvmd gaiasgvskf atlslhdrke rhhekdhkrn
      421 hsmghissks sdklnlvtkt ktdpaktlgt plcprmedvp lleplickki aherltvlif
      481 ledcivtacq egfictwgrp gkvgsqrkst pidseqgqlp hsvcflslsr
//
LOCUS       XP_047287881             523 aa            linear   PRI 05-AUG-2025
DEFINITION  WD repeat-containing protein 20 isoform X14 [Homo sapiens].
ACCESSION   XP_047287881
VERSION     XP_047287881.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431925.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..523
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..523
                     /product="WD repeat-containing protein 20 isoform X14"
                     /calculated_mol_wt=57917
     Region          92..157
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          <147..253
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          162..198
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          205..238
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..523
                     /gene="WDR20"
                     /gene_synonym="Bun107; DMR"
                     /coded_by="XM_047431925.1:28..1599"
                     /db_xref="GeneID:91833"
                     /db_xref="HGNC:HGNC:19667"
                     /db_xref="MIM:617741"
ORIGIN      
        1 mategggkem neiktqfttr eglykllphs eysrpnrvpf nsqgsnpvrv sfvnlndqsg
       61 ngdrlcfnvg relyfyiykg vrkrlidksr vtcvkwvpgs eslflvahss gnmylynveh
      121 tcgttaphyq llkqgesfav htckskstrn pllkwtvgeg alnefafspd gkflacvsqd
      181 gflrvfnfds velhgtmksy fggllcvcws pdgkyivtgg eddlvtvwsf vdcrviargh
      241 ghkswvsvva fdpyttsvee gdpmefsgsd edfqdllhfg rdranstqsr lskrnstdsr
      301 pvsvtyrfgs vgqdtqlclw dltedilfph qplsrartht nvmnatsppa gsngnsvttp
      361 gnsvppplpr snslphsavs nagskssvmd gaiasgvskf atlslhdrke rhhekdhkrn
      421 hsmghissks sdklnlvtkt ktdpaktlgt plcprmedvp lleplickki aherltvlif
      481 ledcivtacq egfictwgrp gkvpaehfcr qedrmqgvlq dqn
//
LOCUS       XP_047287882             520 aa            linear   PRI 05-AUG-2025
DEFINITION  WD repeat-containing protein 20 isoform X15 [Homo sapiens].
ACCESSION   XP_047287882
VERSION     XP_047287882.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431926.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..520
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..520
                     /product="WD repeat-containing protein 20 isoform X15"
                     /calculated_mol_wt=57231
     Region          53..94
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          104..169
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          <159..265
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          174..210
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          217..250
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..520
                     /gene="WDR20"
                     /gene_synonym="Bun107; DMR"
                     /coded_by="XM_047431926.1:329..1891"
                     /db_xref="GeneID:91833"
                     /db_xref="HGNC:HGNC:19667"
                     /db_xref="MIM:617741"
ORIGIN      
        1 mgkrnswlgw lllllkrqsh evgrteilis vlteaadlsk pidkriykgt qptchdfnhl
       61 tataesvsll vgfsagqvql idpikketsk lfneerlidk srvtcvkwvp gseslflvah
      121 ssgnmylynv ehtcgttaph yqllkqgesf avhtckskst rnpllkwtvg egalnefafs
      181 pdgkflacvs qdgflrvfnf dsvelhgtmk syfggllcvc wspdgkyivt ggeddlvtvw
      241 sfvdcrviar ghghkswvsv vafdpyttsv eegdpmefsg sdedfqdllh fgrdranstq
      301 srlskrnstd srpvsvtyrf gsvgqdtqlc lwdltedilf phqplsrart htnvmnatsp
      361 pagsngnsvt tpgnsvpppl prsnslphsa vsnagskssv mdgaiasgvs kfatlslhdr
      421 kerhhekdhk rnhsmghiss kssdklnlvt ktktdpaktl gtplcprmed vplleplick
      481 kiaherltvl ifledcivta cqegfictwg rpgkvvsfnp
//
LOCUS       XP_047287883             488 aa            linear   PRI 05-AUG-2025
DEFINITION  WD repeat-containing protein 20 isoform X16 [Homo sapiens].
ACCESSION   XP_047287883
VERSION     XP_047287883.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431927.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..488
                     /product="WD repeat-containing protein 20 isoform X16"
                     /calculated_mol_wt=53716
     Region          50..115
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          <105..211
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          120..156
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          163..196
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..488
                     /gene="WDR20"
                     /gene_synonym="Bun107; DMR"
                     /coded_by="XM_047431927.1:749..2215"
                     /db_xref="GeneID:91833"
                     /db_xref="HGNC:HGNC:19667"
                     /db_xref="MIM:617741"
ORIGIN      
        1 mtflpsgkdk nscqhlwkvd wneerqnegs ktseealvtv qrlidksrvt cvkwvpgses
       61 lflvahssgn mylynvehtc gttaphyqll kqgesfavht ckskstrnpl lkwtvgegal
      121 nefafspdgk flacvsqdgf lrvfnfdsve lhgtmksyfg gllcvcwspd gkyivtgged
      181 dlvtvwsfvd crviarghgh kswvsvvafd pyttsveegd pmefsgsded fqdllhfgrd
      241 ranstqsrls krnstdsrpv svtyrfgsvg qdtqlclwdl tedilfphqp lsrarthtnv
      301 mnatsppags ngnsvttpgn svppplprsn slphsavsna gskssvmdga iasgvskfat
      361 lslhdrkerh hekdhkrnhs mghisskssd klnlvtktkt dpaktlgtpl cprmedvpll
      421 eplickkiah erltvlifle dcivtacqeg fictwgrpgk vgsqrkstpi dseqgqlphs
      481 vcflslsr
//
LOCUS       XP_011535647             467 aa            linear   PRI 05-AUG-2025
DEFINITION  WD repeat-containing protein 20 isoform X17 [Homo sapiens].
ACCESSION   XP_011535647
VERSION     XP_011535647.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537345.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..467
                     /product="WD repeat-containing protein 20 isoform X17"
                     /calculated_mol_wt=51117
     Region          29..94
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          <84..190
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          99..135
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          142..175
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..467
                     /gene="WDR20"
                     /gene_synonym="Bun107; DMR"
                     /coded_by="XM_011537345.3:230..1633"
                     /db_xref="GeneID:91833"
                     /db_xref="HGNC:HGNC:19667"
                     /db_xref="MIM:617741"
ORIGIN      
        1 mwagsctsis trgsarqshe rlidksrvtc vkwvpgsesl flvahssgnm ylynvehtcg
       61 ttaphyqllk qgesfavhtc kskstrnpll kwtvgegaln efafspdgkf lacvsqdgfl
      121 rvfnfdsvel hgtmksyfgg llcvcwspdg kyivtggedd lvtvwsfvdc rviarghghk
      181 swvsvvafdp yttsveegdp mefsgsdedf qdllhfgrdr anstqsrlsk rnstdsrpvs
      241 vtyrfgsvgq dtqlclwdlt edilfphqpl srarthtnvm natsppagsn gnsvttpgns
      301 vppplprsns lphsavsnag skssvmdgai asgvskfatl slhdrkerhh ekdhkrnhsm
      361 ghisskssdk lnlvtktktd paktlgtplc prmedvplle plickkiahe rltvlifled
      421 civtacqegf ictwgrpgkv gsqrkstpid seqgqlphsv cflslsr
//
LOCUS       XP_006720373             418 aa            linear   PRI 05-AUG-2025
DEFINITION  WD repeat-containing protein 20 isoform X18 [Homo sapiens].
ACCESSION   XP_006720373
VERSION     XP_006720373.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720310.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..418
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..418
                     /product="WD repeat-containing protein 20 isoform X18"
                     /calculated_mol_wt=45814
     Region          <35..141
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          50..86
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          93..126
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..418
                     /gene="WDR20"
                     /gene_synonym="Bun107; DMR"
                     /coded_by="XM_006720310.2:873..2129"
                     /db_xref="GeneID:91833"
                     /db_xref="HGNC:HGNC:19667"
                     /db_xref="MIM:617741"
ORIGIN      
        1 mylynvehtc gttaphyqll kqgesfavht ckskstrnpl lkwtvgegal nefafspdgk
       61 flacvsqdgf lrvfnfdsve lhgtmksyfg gllcvcwspd gkyivtgged dlvtvwsfvd
      121 crviarghgh kswvsvvafd pyttsveegd pmefsgsded fqdllhfgrd ranstqsrls
      181 krnstdsrpv svtyrfgsvg qdtqlclwdl tedilfphqp lsrarthtnv mnatsppags
      241 ngnsvttpgn svppplprsn slphsavsna gskssvmdga iasgvskfat lslhdrkerh
      301 hekdhkrnhs mghisskssd klnlvtktkt dpaktlgtpl cprmedvpll eplickkiah
      361 erltvlifle dcivtacqeg fictwgrpgk vgsqrkstpi dseqgqlphs vcflslsr
//
LOCUS       XP_011535648             418 aa            linear   PRI 05-AUG-2025
DEFINITION  WD repeat-containing protein 20 isoform X18 [Homo sapiens].
ACCESSION   XP_011535648
VERSION     XP_011535648.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537346.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..418
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..418
                     /product="WD repeat-containing protein 20 isoform X18"
                     /calculated_mol_wt=45814
     Region          <35..141
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          50..86
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          93..126
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..418
                     /gene="WDR20"
                     /gene_synonym="Bun107; DMR"
                     /coded_by="XM_011537346.2:391..1647"
                     /db_xref="GeneID:91833"
                     /db_xref="HGNC:HGNC:19667"
                     /db_xref="MIM:617741"
ORIGIN      
        1 mylynvehtc gttaphyqll kqgesfavht ckskstrnpl lkwtvgegal nefafspdgk
       61 flacvsqdgf lrvfnfdsve lhgtmksyfg gllcvcwspd gkyivtgged dlvtvwsfvd
      121 crviarghgh kswvsvvafd pyttsveegd pmefsgsded fqdllhfgrd ranstqsrls
      181 krnstdsrpv svtyrfgsvg qdtqlclwdl tedilfphqp lsrarthtnv mnatsppags
      241 ngnsvttpgn svppplprsn slphsavsna gskssvmdga iasgvskfat lslhdrkerh
      301 hekdhkrnhs mghisskssd klnlvtktkt dpaktlgtpl cprmedvpll eplickkiah
      361 erltvlifle dcivtacqeg fictwgrpgk vgsqrkstpi dseqgqlphs vcflslsr
//
LOCUS       XP_024305510             418 aa            linear   PRI 05-AUG-2025
DEFINITION  WD repeat-containing protein 20 isoform X18 [Homo sapiens].
ACCESSION   XP_024305510
VERSION     XP_024305510.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449742.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..418
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..418
                     /product="WD repeat-containing protein 20 isoform X18"
                     /calculated_mol_wt=45814
     Region          <35..141
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          50..86
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          93..126
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..418
                     /gene="WDR20"
                     /gene_synonym="Bun107; DMR"
                     /coded_by="XM_024449742.2:578..1834"
                     /db_xref="GeneID:91833"
                     /db_xref="HGNC:HGNC:19667"
                     /db_xref="MIM:617741"
ORIGIN      
        1 mylynvehtc gttaphyqll kqgesfavht ckskstrnpl lkwtvgegal nefafspdgk
       61 flacvsqdgf lrvfnfdsve lhgtmksyfg gllcvcwspd gkyivtgged dlvtvwsfvd
      121 crviarghgh kswvsvvafd pyttsveegd pmefsgsded fqdllhfgrd ranstqsrls
      181 krnstdsrpv svtyrfgsvg qdtqlclwdl tedilfphqp lsrarthtnv mnatsppags
      241 ngnsvttpgn svppplprsn slphsavsna gskssvmdga iasgvskfat lslhdrkerh
      301 hekdhkrnhs mghisskssd klnlvtktkt dpaktlgtpl cprmedvpll eplickkiah
      361 erltvlifle dcivtacqeg fictwgrpgk vgsqrkstpi dseqgqlphs vcflslsr
//
LOCUS       XP_047287884             418 aa            linear   PRI 05-AUG-2025
DEFINITION  WD repeat-containing protein 20 isoform X18 [Homo sapiens].
ACCESSION   XP_047287884
VERSION     XP_047287884.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431928.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..418
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..418
                     /product="WD repeat-containing protein 20 isoform X18"
                     /calculated_mol_wt=45814
     Region          <35..141
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          50..86
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          93..126
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..418
                     /gene="WDR20"
                     /gene_synonym="Bun107; DMR"
                     /coded_by="XM_047431928.1:192..1448"
                     /db_xref="GeneID:91833"
                     /db_xref="HGNC:HGNC:19667"
                     /db_xref="MIM:617741"
ORIGIN      
        1 mylynvehtc gttaphyqll kqgesfavht ckskstrnpl lkwtvgegal nefafspdgk
       61 flacvsqdgf lrvfnfdsve lhgtmksyfg gllcvcwspd gkyivtgged dlvtvwsfvd
      121 crviarghgh kswvsvvafd pyttsveegd pmefsgsded fqdllhfgrd ranstqsrls
      181 krnstdsrpv svtyrfgsvg qdtqlclwdl tedilfphqp lsrarthtnv mnatsppags
      241 ngnsvttpgn svppplprsn slphsavsna gskssvmdga iasgvskfat lslhdrkerh
      301 hekdhkrnhs mghisskssd klnlvtktkt dpaktlgtpl cprmedvpll eplickkiah
      361 erltvlifle dcivtacqeg fictwgrpgk vgsqrkstpi dseqgqlphs vcflslsr
//
LOCUS       XP_024305511             418 aa            linear   PRI 05-AUG-2025
DEFINITION  WD repeat-containing protein 20 isoform X18 [Homo sapiens].
ACCESSION   XP_024305511
VERSION     XP_024305511.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449743.2
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 18% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..418
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..418
                     /product="WD repeat-containing protein 20 isoform X18"
                     /calculated_mol_wt=45814
     Region          <35..141
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          50..86
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          93..126
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..418
                     /gene="WDR20"
                     /gene_synonym="Bun107; DMR"
                     /coded_by="XM_024449743.2:671..1927"
                     /db_xref="GeneID:91833"
                     /db_xref="HGNC:HGNC:19667"
                     /db_xref="MIM:617741"
ORIGIN      
        1 mylynvehtc gttaphyqll kqgesfavht ckskstrnpl lkwtvgegal nefafspdgk
       61 flacvsqdgf lrvfnfdsve lhgtmksyfg gllcvcwspd gkyivtgged dlvtvwsfvd
      121 crviarghgh kswvsvvafd pyttsveegd pmefsgsded fqdllhfgrd ranstqsrls
      181 krnstdsrpv svtyrfgsvg qdtqlclwdl tedilfphqp lsrarthtnv mnatsppags
      241 ngnsvttpgn svppplprsn slphsavsna gskssvmdga iasgvskfat lslhdrkerh
      301 hekdhkrnhs mghisskssd klnlvtktkt dpaktlgtpl cprmedvpll eplickkiah
      361 erltvlifle dcivtacqeg fictwgrpgk vgsqrkstpi dseqgqlphs vcflslsr
//
LOCUS       XP_047287885             214 aa            linear   PRI 05-AUG-2025
DEFINITION  WD repeat-containing protein 20 isoform X19 [Homo sapiens].
ACCESSION   XP_047287885
VERSION     XP_047287885.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431929.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..214
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..214
                     /product="WD repeat-containing protein 20 isoform X19"
                     /calculated_mol_wt=23781
     CDS             1..214
                     /gene="WDR20"
                     /gene_synonym="Bun107; DMR"
                     /coded_by="XM_047431929.1:28..672"
                     /db_xref="GeneID:91833"
                     /db_xref="HGNC:HGNC:19667"
                     /db_xref="MIM:617741"
ORIGIN      
        1 mategggkem neiktqfttr eglykllphs eysrpnrvpf nsqgsnpvrv sfvnlndqsg
       61 ngdrlcfnvg relyfyiykg vrkvptrasp epasgaadls kpidkriykg tqptchdfnh
      121 ltataesvsl lvgfsagqvq lidpikkets klfneenscq hlwkvdwnee rqnegsktse
      181 ealvtvqgsq rkstpidseq gqlphsvcfl slsr
//
LOCUS       XP_047287886             205 aa            linear   PRI 05-AUG-2025
DEFINITION  WD repeat-containing protein 20 isoform X20 [Homo sapiens].
ACCESSION   XP_047287886
VERSION     XP_047287886.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431930.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..205
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..205
                     /product="WD repeat-containing protein 20 isoform X20"
                     /calculated_mol_wt=22801
     CDS             1..205
                     /gene="WDR20"
                     /gene_synonym="Bun107; DMR"
                     /coded_by="XM_047431930.1:28..645"
                     /db_xref="GeneID:91833"
                     /db_xref="HGNC:HGNC:19667"
                     /db_xref="MIM:617741"
ORIGIN      
        1 mategggkem neiktqfttr eglykllphs eysrpnrvpf nsqgsnpvrv sfvnlndqsg
       61 ngdrlcfnvg relyfyiykg vrkvptrasp epasgaadls kpidkriykg tqptchdfnh
      121 ltataesvsl lvgfsagqvq lidpikkets klfneenscq hlwkvdwnee rqnegsktse
      181 ealvtvqavr lrqthwvgpt spcgi
//
LOCUS       XP_011535654             204 aa            linear   PRI 05-AUG-2025
DEFINITION  WD repeat-containing protein 20 isoform X21 [Homo sapiens].
ACCESSION   XP_011535654
VERSION     XP_011535654.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537352.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..204
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..204
                     /product="WD repeat-containing protein 20 isoform X21"
                     /calculated_mol_wt=22340
     CDS             1..204
                     /gene="WDR20"
                     /gene_synonym="Bun107; DMR"
                     /coded_by="XM_011537352.4:28..642"
                     /db_xref="GeneID:91833"
                     /db_xref="HGNC:HGNC:19667"
                     /db_xref="MIM:617741"
ORIGIN      
        1 mategggkem neiktqfttr eglykllphs eysrpnrvpf nsqgsnpvrv sfvnlndqsg
       61 ngdrlcfnvg relyfyiykg vrkvptrasp epasgaadls kpidkriykg tqptchdfnh
      121 ltataesvsl lvgfsagqvq lidpikkets klfneenscq hlwkvdwnee rqnegsktse
      181 ealvtvqgsl sspsqasspg gtvv
//
LOCUS       XP_011535655             191 aa            linear   PRI 05-AUG-2025
DEFINITION  WD repeat-containing protein 20 isoform X22 [Homo sapiens].
ACCESSION   XP_011535655
VERSION     XP_011535655.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537353.4
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 48% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..191
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..191
                     /product="WD repeat-containing protein 20 isoform X22"
                     /calculated_mol_wt=21217
     CDS             1..191
                     /gene="WDR20"
                     /gene_synonym="Bun107; DMR"
                     /coded_by="XM_011537353.4:28..603"
                     /db_xref="GeneID:91833"
                     /db_xref="HGNC:HGNC:19667"
                     /db_xref="MIM:617741"
ORIGIN      
        1 mategggkem neiktqfttr eglykllphs eysrpnrvpf nsqgsnpvrv sfvnlndqsg
       61 ngdrlcfnvg relyfyiykg vrkvptrasp epasgaadls kpidkriykg tqptchdfnh
      121 ltataesvsl lvgfsagqvq lidpikkets klfneenscq hlwkvdwnee rqnegsktse
      181 ealvtvqmas s
//
LOCUS       XP_047287887             183 aa            linear   PRI 05-AUG-2025
DEFINITION  WD repeat-containing protein 20 isoform X23 [Homo sapiens].
ACCESSION   XP_047287887
VERSION     XP_047287887.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431931.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..183
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..183
                     /product="WD repeat-containing protein 20 isoform X23"
                     /calculated_mol_wt=20153
     CDS             1..183
                     /gene="WDR20"
                     /gene_synonym="Bun107; DMR"
                     /coded_by="XM_047431931.1:28..579"
                     /db_xref="GeneID:91833"
                     /db_xref="HGNC:HGNC:19667"
                     /db_xref="MIM:617741"
ORIGIN      
        1 mategggkem neiktqfttr eglykllphs eysrpnrvpf nsqgsnpvrv sfvnlndqsg
       61 ngdrlcfnvg relyfyiykg vrkvptrasp epasgaadls kpidkriykg tqptchdfnh
      121 ltataesvsl lvgfsagqvq lidpikkets klfneegsqr kstpidseqg qlphsvcfls
      181 lsr
//
LOCUS       XP_047287888             179 aa            linear   PRI 05-AUG-2025
DEFINITION  WD repeat-containing protein 20 isoform X24 [Homo sapiens].
ACCESSION   XP_047287888
VERSION     XP_047287888.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431932.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..179
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..179
                     /product="WD repeat-containing protein 20 isoform X24"
                     /calculated_mol_wt=20067
     CDS             1..179
                     /gene="WDR20"
                     /gene_synonym="Bun107; DMR"
                     /coded_by="XM_047431932.1:28..567"
                     /db_xref="GeneID:91833"
                     /db_xref="HGNC:HGNC:19667"
                     /db_xref="MIM:617741"
ORIGIN      
        1 mategggkem neiktqfttr eglykllphs eysrpnrvpf nsqgsnpvrv sfvnlndqsg
       61 ngdrlcfnvg relyfyiykg vrkaadlskp idkriykgtq ptchdfnhlt ataesvsllv
      121 gfsagqvqli dpikketskl fneenscqhl wkvdwneerq negsktseea lvtvqmass
//
LOCUS       XP_011535658             173 aa            linear   PRI 05-AUG-2025
DEFINITION  WD repeat-containing protein 20 isoform X25 [Homo sapiens].
ACCESSION   XP_011535658
VERSION     XP_011535658.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537356.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..173
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..173
                     /product="WD repeat-containing protein 20 isoform X25"
                     /calculated_mol_wt=18712
     CDS             1..173
                     /gene="WDR20"
                     /gene_synonym="Bun107; DMR"
                     /coded_by="XM_011537356.4:28..549"
                     /db_xref="GeneID:91833"
                     /db_xref="HGNC:HGNC:19667"
                     /db_xref="MIM:617741"
ORIGIN      
        1 mategggkem neiktqfttr eglykllphs eysrpnrvpf nsqgsnpvrv sfvnlndqsg
       61 ngdrlcfnvg relyfyiykg vrkvptrasp epasgaadls kpidkriykg tqptchdfnh
      121 ltataesvsl lvgfsagqvq lidpikkets klfneegsls spsqasspgg tvv
//
LOCUS       XP_047287889             148 aa            linear   PRI 05-AUG-2025
DEFINITION  WD repeat-containing protein 20 isoform X26 [Homo sapiens].
ACCESSION   XP_047287889
VERSION     XP_047287889.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431933.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..148
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..148
                     /product="WD repeat-containing protein 20 isoform X26"
                     /calculated_mol_wt=16439
     CDS             1..148
                     /gene="WDR20"
                     /gene_synonym="Bun107; DMR"
                     /coded_by="XM_047431933.1:28..474"
                     /db_xref="GeneID:91833"
                     /db_xref="HGNC:HGNC:19667"
                     /db_xref="MIM:617741"
ORIGIN      
        1 mategggkem neiktqfttr eglykllphs eysrpnrvpf nsqgsnpvrv sfvnlndqsg
       61 ngdrlcfnvg relyfyiykg vrkaadlskp idkriykgtq ptchdfnhlt ataesvsllv
      121 gfsagqvqli dpikketskl fneemass
//
LOCUS       XP_047287891            1537 aa            linear   PRI 05-AUG-2025
DEFINITION  thyroid receptor-interacting protein 11 isoform X1 [Homo sapiens].
ACCESSION   XP_047287891
VERSION     XP_047287891.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431935.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1537
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1537
                     /product="thyroid receptor-interacting protein 11 isoform
                     X1"
                     /calculated_mol_wt=177299
     Region          <8..793
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          466..1310
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          1332..1377
                     /region_name="GRAB"
                     /note="GRAB domain; pfam10375"
                     /db_xref="CDD:431241"
     CDS             1..1537
                     /gene="TRIP11"
                     /gene_synonym="ACG1A; CEV14; GMAP-210; GMAP210; ODCD;
                     ODCD1; TRIP-11; TRIP230"
                     /coded_by="XM_047431935.1:101..4714"
                     /db_xref="GeneID:9321"
                     /db_xref="HGNC:HGNC:12305"
                     /db_xref="MIM:604505"
ORIGIN      
        1 msllklnney evikstatrd isldselhdl rlnleakeqe lnqsiseket liaeieeldr
       61 qnqeatkhmi likdqlskqq negdsiiskl kqdlndekkr vhqleddkmd itkeldvqke
      121 kliqsevaln dlhltkqkle dkvenlvdql nksqesnvsi qkenlelkeh irqneeelsr
      181 irnelmqsln qdsnsnfkdt llkereaevr nlkqnlsele qlnenlkkva fdvkmenekl
      241 vlacedvrhq leeclagnnq lslekntive tlkmekgeie aelcwakkrl leeankyekt
      301 ieelsnarnl ntsalqlehe hliklnqkkd meiaelkkni eqmdtdhket kdvlssslee
      361 qkqltqlink keifieklke rssklqeeld kysqalrkne ilrqtieekd rslgsmkeen
      421 nhlqeelerl reeqsrtapv adpktldsvt elasevsqln tikehleeei khhqkiiedq
      481 nqskmqllqs lqeqkkemde fryqheqmna thtqlflekd eeikslqkti eqiktqlhee
      541 rqdiqtdnsd ifqetkvqsl niengsekhd lskaeterlv kgikerelei kllneknisl
      601 tkqidqlskd evgkltqiiq qkdleiqalh arisstshtq dvvylqqqlq ayamerekvf
      661 avlnektren shlkteyhkm mdivaakeaa liklqdenkk lstrfessgq dmfretiqnl
      721 sriirekdie idalsqkcqt llavlqtsst gneaggvnsn qfeellqerd klkqqvkkme
      781 ewkqqvmttv qnmqhesaql qeelhqlqaq vlvdsdnnsk lqvdytgliq syeqnetklk
      841 nfgqelaqvq hsigqlcntk dlllgkldii spqlssasll tpqsaeclra sksevlsess
      901 ellqqeleel rkslqekdat irtlqennhr lsdsiaatse lerkeheqtd seikqlkekq
      961 dvlqkllkek dllikaksdq llssnenftn kvnenellrq avtnlkeril ilemdigklk
     1021 genekivety rgketeyqal qetnmkfsmm lrekefechs mkekalafeq llkekeqgkt
     1081 gelnqllnav ksmqektvvf qqerdqvmla lkqkqmenta lqnevqrlrd kefrsnqele
     1141 rlrnhllese dsytrealaa edreaklrkk vtvleeklvs ssnamenash qasvqveslq
     1201 eqlnvvskqr detalqlsvs qeqvkqyals lanlqmvleh fqqeekamys aelekqkqli
     1261 aewkknaenl egkvislqec ldeanaalds asrlteqldv keeqieelkr qnelrqemld
     1321 dvqkklmsla nssegkvdkv lmrnlfighf htpknqrhev lrlmgsilgv rreemeqlfh
     1381 ddqggvtrwm tgwlgggsks vpntplrpnq qsvvnssfse lfvkfletes hpsipppkls
     1441 vhdmkpldsp grrkrdtnap esfkdtaesr sgrrtdvnpf laprsaavpl inpaglgpgg
     1501 pghlllkpis dvlptftplp alpdnsagvv lkdllkq
//
LOCUS       XP_011535664             247 aa            linear   PRI 05-AUG-2025
DEFINITION  MAPK-interacting and spindle-stabilizing protein-like isoform X1
            [Homo sapiens].
ACCESSION   XP_011535664
VERSION     XP_011535664.3
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537362.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XP_011535664.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..247
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..247
                     /product="MAPK-interacting and spindle-stabilizing
                     protein-like isoform X1"
                     /calculated_mol_wt=24397
     Region          7..244
                     /region_name="MISS"
                     /note="MAPK-interacting and spindle-stabilising
                     protein-like; pfam15822"
                     /db_xref="CDD:318115"
     CDS             1..247
                     /gene="MAPK1IP1L"
                     /gene_synonym="C14orf32; c14_5346; MISS"
                     /coded_by="XM_011537362.3:18..761"
                     /db_xref="GeneID:93487"
                     /db_xref="HGNC:HGNC:19840"
                     /db_xref="MIM:617226"
ORIGIN      
        1 mkmsdefsla dalpehspak tsavsntkpg qppqgwpgsn pwnnpsapss vpsglppsat
       61 pstvpfgpap tgmypsvppt gpppgppapf ppsgpscppp ggpypaptvp gpgptgpypt
      121 pnmpfpelpr pygaptdpaa agplgpwgsm ssgpwapgmg gqyptpnmpy pspgpypapp
      181 ppqapgaapp vpwgtvppga wgppapypap tgsyptpgly ptpsnpfqvp sgpsgappmp
      241 ggphsyh
//
LOCUS       XP_011535665            1687 aa            linear   PRI 05-AUG-2025
DEFINITION  neurexin 3 isoform X1 [Homo sapiens].
ACCESSION   XP_011535665
VERSION     XP_011535665.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537363.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1687
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1687
                     /product="neurexin 3 isoform X1"
                     /calculated_mol_wt=185623
     Region          35..181
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          202..232
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          286..425
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          482..631
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          659..692
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          720..854
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          911..1039
                     /region_name="Laminin_G_2"
                     /note="Laminin G domain; pfam02210"
                     /db_xref="CDD:460494"
     Region          1103..1282
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          1613..1669
                     /region_name="Syndecan"
                     /note="Syndecan domain; pfam01034"
                     /db_xref="CDD:460035"
     Region          1633..1651
                     /region_name="4.1m"
                     /note="putative band 4.1 homologues' binding motif;
                     smart00294"
                     /db_xref="CDD:128590"
     CDS             1..1687
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /coded_by="XM_011537363.2:1006..6069"
                     /db_xref="GeneID:9369"
                     /db_xref="HGNC:HGNC:8010"
                     /db_xref="MIM:600567"
ORIGIN      
        1 msstlhsvff tlkvsillgs llglclglef mglpnqwary lrwdastrsd lsfqfktnvs
       61 tglllylddg gvcdflclsl vdgrvqlrfs mdcaetavls nkqvndsswh flmvsrdrlr
      121 tvlmldgegq sgelqpqrpy mdvvsdlflg gvptdirpsa ltldgvqamp gfkglildlk
      181 ygnseprllg srgvqmdaeg pcgerpceng gicflldghp tcdcsttgyg gklcsedvsq
      241 dpglshlmms eqgrskaree nvatfrgsey lcydlsqnpi qsssdeitls fktwqrngli
      301 lhtgksadyv nlalkdgavs lvinlgsgaf eaivepvngk fndnawhdvk vtrnlrqhsg
      361 ighamvtisv dgiltttgyt qedytmlgsd dffyvggsps tadlpgspvs nnfmgclkev
      421 vyknndirle lsrlariadt kmkiygevvf kcenvatldp infetpeayi slpkwntkrm
      481 gsisfdfrtt epnglilfth gkpqerkdar sqkntkvdff avelldgnly llldmgsgti
      541 kvkatqkkan dgewyhvdiq rdgrsgtisv nsrrtpftas geseildleg dmylgglpen
      601 raglilptel wtamlnygyv gcirdlfidg rsknirqlae mqnaagvkss csrmsakqcd
      661 sypcknnavc kdgwnrficd ctgtgywgrt cereasilsy dgsmymkiim pmvmhteaed
      721 vsfrfmsqra ygllvattsr dsadtlrlel dggrvklmvn ldcirincns skgpetlyag
      781 qklndnewht vrvvrrgksl kltvdddvae gtmvgdhtrl efhnietgim tekryisvvp
      841 ssfighlqsl mfngllyidl ckngdidyce lkarfglrni iadpvtfktk ssylslatlq
      901 aytsmhlffq fkttspdgfi lfnsgdgndf iavelvkgyi hyvfdlgngp nvikgnsdrp
      961 lndnqwhnvv itrdnsnths lkvdtkvvtq vingaknldl kgdlymagla qgmysnlpkl
     1021 vasrdgfqgc lasvdlngrl pdlindalhr sgqiergceg psttcqedsc anqgvcmqqw
     1081 egftcdcsmt sysgnqcndp gatyifgksg glilytwpan drpstrsdrl avgfsttvkd
     1141 gilvridsap glgdflqlhi eqgkigvvfn igtvdisike ertpvndgky hvvrftrngg
     1201 natlqvdnwp vnehyptgnt dnerfqmvkq kipfkynrpv eewlqekgrq ltifntqaqi
     1261 aiggkdkgrl fqgqlsglyy dglkvlnmaa ennpniking svrlvgevps ilgttqttsm
     1321 ppemsttvme ttttmatttt rknrstasiq ptsddlvssa ecssddedfv ecepstgrsg
     1381 gelvipllve dplatppiat rapsitlppt frplltiiet tkdslsmtse aglpclsdqg
     1441 sdgcdddglv isgygsgetf dsnlpptdde dfyttfslvt dkslstsife ggykahapkw
     1501 eskdfrpnkv setsrtttts lspelirfta ssssgmvpkl pagkmnnrdl kpqpdivllp
     1561 lptayeldst klksplitsp mfrnvptanp tepgirrvpg aseviresss ttgmvvgiva
     1621 aaalcilill yamykyrnrd egsyqvdetr nyisnsaqsn gtlmkekqqs sksghkkqkn
     1681 kdreyyv
//
LOCUS       XP_005268275            1684 aa            linear   PRI 05-AUG-2025
DEFINITION  neurexin 3 isoform X2 [Homo sapiens].
ACCESSION   XP_005268275
VERSION     XP_005268275.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005268218.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1684
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1684
                     /product="neurexin 3 isoform X2"
                     /calculated_mol_wt=185323
     Region          35..181
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          202..232
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          286..425
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          482..631
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          659..692
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          720..854
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          911..1039
                     /region_name="Laminin_G_2"
                     /note="Laminin G domain; pfam02210"
                     /db_xref="CDD:460494"
     Region          1103..1282
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          1610..1666
                     /region_name="Syndecan"
                     /note="Syndecan domain; pfam01034"
                     /db_xref="CDD:460035"
     Region          1630..1648
                     /region_name="4.1m"
                     /note="putative band 4.1 homologues' binding motif;
                     smart00294"
                     /db_xref="CDD:128590"
     CDS             1..1684
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /coded_by="XM_005268218.4:1006..6060"
                     /db_xref="GeneID:9369"
                     /db_xref="HGNC:HGNC:8010"
                     /db_xref="MIM:600567"
ORIGIN      
        1 msstlhsvff tlkvsillgs llglclglef mglpnqwary lrwdastrsd lsfqfktnvs
       61 tglllylddg gvcdflclsl vdgrvqlrfs mdcaetavls nkqvndsswh flmvsrdrlr
      121 tvlmldgegq sgelqpqrpy mdvvsdlflg gvptdirpsa ltldgvqamp gfkglildlk
      181 ygnseprllg srgvqmdaeg pcgerpceng gicflldghp tcdcsttgyg gklcsedvsq
      241 dpglshlmms eqgrskaree nvatfrgsey lcydlsqnpi qsssdeitls fktwqrngli
      301 lhtgksadyv nlalkdgavs lvinlgsgaf eaivepvngk fndnawhdvk vtrnlrqhsg
      361 ighamvtisv dgiltttgyt qedytmlgsd dffyvggsps tadlpgspvs nnfmgclkev
      421 vyknndirle lsrlariadt kmkiygevvf kcenvatldp infetpeayi slpkwntkrm
      481 gsisfdfrtt epnglilfth gkpqerkdar sqkntkvdff avelldgnly llldmgsgti
      541 kvkatqkkan dgewyhvdiq rdgrsgtisv nsrrtpftas geseildleg dmylgglpen
      601 raglilptel wtamlnygyv gcirdlfidg rsknirqlae mqnaagvkss csrmsakqcd
      661 sypcknnavc kdgwnrficd ctgtgywgrt cereasilsy dgsmymkiim pmvmhteaed
      721 vsfrfmsqra ygllvattsr dsadtlrlel dggrvklmvn ldcirincns skgpetlyag
      781 qklndnewht vrvvrrgksl kltvdddvae gtmvgdhtrl efhnietgim tekryisvvp
      841 ssfighlqsl mfngllyidl ckngdidyce lkarfglrni iadpvtfktk ssylslatlq
      901 aytsmhlffq fkttspdgfi lfnsgdgndf iavelvkgyi hyvfdlgngp nvikgnsdrp
      961 lndnqwhnvv itrdnsnths lkvdtkvvtq vingaknldl kgdlymagla qgmysnlpkl
     1021 vasrdgfqgc lasvdlngrl pdlindalhr sgqiergceg psttcqedsc anqgvcmqqw
     1081 egftcdcsmt sysgnqcndp gatyifgksg glilytwpan drpstrsdrl avgfsttvkd
     1141 gilvridsap glgdflqlhi eqgkigvvfn igtvdisike ertpvndgky hvvrftrngg
     1201 natlqvdnwp vnehyptgnt dnerfqmvkq kipfkynrpv eewlqekgrq ltifntqaqi
     1261 aiggkdkgrl fqgqlsglyy dglkvlnmaa ennpniking svrlvgevps ilgttqttsm
     1321 ppemsttvme ttttmatttt rknrstasiq ptsddlvssa ecssddedfv ecepstggel
     1381 vipllvedpl atppiatrap sitlpptfrp lltiiettkd slsmtseagl pclsdqgsdg
     1441 cdddglvisg ygsgetfdsn lpptddedfy ttfslvtdks lstsifeggy kahapkwesk
     1501 dfrpnkvset srttttslsp elirftasss sgmvpklpag kmnnrdlkpq pdivllplpt
     1561 ayeldstklk splitspmfr nvptanptep girrvpgase viresssttg mvvgivaaaa
     1621 lcilillyam ykyrnrdegs yqvdetrnyi snsaqsngtl mkekqqssks ghkkqknkdr
     1681 eyyv
//
LOCUS       XP_006720385            1683 aa            linear   PRI 05-AUG-2025
DEFINITION  neurexin 3 isoform X3 [Homo sapiens].
ACCESSION   XP_006720385
VERSION     XP_006720385.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720322.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1683
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1683
                     /product="neurexin 3 isoform X3"
                     /calculated_mol_wt=185194
     Region          35..181
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          202..232
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          282..421
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          478..627
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          655..688
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          716..850
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          907..1035
                     /region_name="Laminin_G_2"
                     /note="Laminin G domain; pfam02210"
                     /db_xref="CDD:460494"
     Region          1099..1278
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          1609..1665
                     /region_name="Syndecan"
                     /note="Syndecan domain; pfam01034"
                     /db_xref="CDD:460035"
     Region          1629..1647
                     /region_name="4.1m"
                     /note="putative band 4.1 homologues' binding motif;
                     smart00294"
                     /db_xref="CDD:128590"
     CDS             1..1683
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /coded_by="XM_006720322.3:1006..6057"
                     /db_xref="GeneID:9369"
                     /db_xref="HGNC:HGNC:8010"
                     /db_xref="MIM:600567"
ORIGIN      
        1 msstlhsvff tlkvsillgs llglclglef mglpnqwary lrwdastrsd lsfqfktnvs
       61 tglllylddg gvcdflclsl vdgrvqlrfs mdcaetavls nkqvndsswh flmvsrdrlr
      121 tvlmldgegq sgelqpqrpy mdvvsdlflg gvptdirpsa ltldgvqamp gfkglildlk
      181 ygnseprllg srgvqmdaeg pcgerpceng gicflldghp tcdcsttgyg gklcsedvsq
      241 dpglshlmms eqareenvat frgseylcyd lsqnpiqsss deitlsfktw qrnglilhtg
      301 ksadyvnlal kdgavslvin lgsgafeaiv epvngkfndn awhdvkvtrn lrqhsgigha
      361 mvtisvdgil tttgytqedy tmlgsddffy vggspstadl pgspvsnnfm gclkevvykn
      421 ndirlelsrl ariadtkmki ygevvfkcen vatldpinfe tpeayislpk wntkrmgsis
      481 fdfrttepng lilfthgkpq erkdarsqkn tkvdffavel ldgnlyllld mgsgtikvka
      541 tqkkandgew yhvdiqrdgr sgtisvnsrr tpftasgese ildlegdmyl gglpenragl
      601 ilptelwtam lnygyvgcir dlfidgrskn irqlaemqna agvksscsrm sakqcdsypc
      661 knnavckdgw nrficdctgt gywgrtcere asilsydgsm ymkiimpmvm hteaedvsfr
      721 fmsqraygll vattsrdsad tlrleldggr vklmvnldci rincnsskgp etlyagqkln
      781 dnewhtvrvv rrgkslkltv dddvaegtmv gdhtrlefhn ietgimtekr yisvvpssfi
      841 ghlqslmfng llyidlckng didycelkar fglrniiadp vtfktkssyl slatlqayts
      901 mhlffqfktt spdgfilfns gdgndfiave lvkgyihyvf dlgngpnvik gnsdrplndn
      961 qwhnvvitrd nsnthslkvd tkvvtqving aknldlkgdl ymaglaqgmy snlpklvasr
     1021 dgfqgclasv dlngrlpdli ndalhrsgqi ergcegpstt cqedscanqg vcmqqwegft
     1081 cdcsmtsysg nqcndpgaty ifgksgglil ytwpandrps trsdrlavgf sttvkdgilv
     1141 ridsapglgd flqlhieqgk igvvfnigtv disikeertp vndgkyhvvr ftrnggnatl
     1201 qvdnwpvneh yptgntdner fqmvkqkipf kynrpveewl qekgrqltif ntqaqiaigg
     1261 kdkgrlfqgq lsglyydglk vlnmaaennp nikingsvrl vgevpsilgt tqttsmppem
     1321 sttvmetttt mattttrknr stasiqptsd dlvssaecss ddedfvecep stgrsggelv
     1381 ipllvedpla tppiatraps itlpptfrpl ltiiettkds lsmtseaglp clsdqgsdgc
     1441 dddglvisgy gsgetfdsnl pptddedfyt tfslvtdksl stsifeggyk ahapkweskd
     1501 frpnkvsets rttttslspe lirftassss gmvpklpagk mnnrdlkpqp divllplpta
     1561 yeldstklks plitspmfrn vptanptepg irrvpgasev iresssttgm vvgivaaaal
     1621 cilillyamy kyrnrdegsy qvdetrnyis nsaqsngtlm kekqqssksg hkkqknkdre
     1681 yyv
//
LOCUS       XP_011535668            1679 aa            linear   PRI 05-AUG-2025
DEFINITION  neurexin 3 isoform X4 [Homo sapiens].
ACCESSION   XP_011535668
VERSION     XP_011535668.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537366.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1679
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1679
                     /product="neurexin 3 isoform X4"
                     /calculated_mol_wt=184832
     Region          35..181
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          202..232
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          286..417
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          474..623
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          651..684
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          712..846
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          903..1031
                     /region_name="Laminin_G_2"
                     /note="Laminin G domain; pfam02210"
                     /db_xref="CDD:460494"
     Region          1095..1274
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          1605..1661
                     /region_name="Syndecan"
                     /note="Syndecan domain; pfam01034"
                     /db_xref="CDD:460035"
     Region          1625..1643
                     /region_name="4.1m"
                     /note="putative band 4.1 homologues' binding motif;
                     smart00294"
                     /db_xref="CDD:128590"
     CDS             1..1679
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /coded_by="XM_011537366.2:1006..6045"
                     /db_xref="GeneID:9369"
                     /db_xref="HGNC:HGNC:8010"
                     /db_xref="MIM:600567"
ORIGIN      
        1 msstlhsvff tlkvsillgs llglclglef mglpnqwary lrwdastrsd lsfqfktnvs
       61 tglllylddg gvcdflclsl vdgrvqlrfs mdcaetavls nkqvndsswh flmvsrdrlr
      121 tvlmldgegq sgelqpqrpy mdvvsdlflg gvptdirpsa ltldgvqamp gfkglildlk
      181 ygnseprllg srgvqmdaeg pcgerpceng gicflldghp tcdcsttgyg gklcsedvsq
      241 dpglshlmms eqgrskaree nvatfrgsey lcydlsqnpi qsssdeitls fktwqrngli
      301 lhtgksadyv nlalkdgavs lvinlgsgaf eaivepvngk fndnawhdvk vtrnlrqvti
      361 svdgiltttg ytqedytmlg sddffyvggs pstadlpgsp vsnnfmgclk evvyknndir
      421 lelsrlaria dtkmkiygev vfkcenvatl dpinfetpea yislpkwntk rmgsisfdfr
      481 ttepnglilf thgkpqerkd arsqkntkvd ffavelldgn lyllldmgsg tikvkatqkk
      541 andgewyhvd iqrdgrsgti svnsrrtpft asgeseildl egdmylgglp enraglilpt
      601 elwtamlnyg yvgcirdlfi dgrsknirql aemqnaagvk sscsrmsakq cdsypcknna
      661 vckdgwnrfi cdctgtgywg rtcereasil sydgsmymki impmvmhtea edvsfrfmsq
      721 raygllvatt srdsadtlrl eldggrvklm vnldcirinc nsskgpetly agqklndnew
      781 htvrvvrrgk slkltvdddv aegtmvgdht rlefhnietg imtekryisv vpssfighlq
      841 slmfngllyi dlckngdidy celkarfglr niiadpvtfk tkssylslat lqaytsmhlf
      901 fqfkttspdg filfnsgdgn dfiavelvkg yihyvfdlgn gpnvikgnsd rplndnqwhn
      961 vvitrdnsnt hslkvdtkvv tqvingaknl dlkgdlymag laqgmysnlp klvasrdgfq
     1021 gclasvdlng rlpdlindal hrsgqiergc egpsttcqed scanqgvcmq qwegftcdcs
     1081 mtsysgnqcn dpgatyifgk sgglilytwp andrpstrsd rlavgfsttv kdgilvrids
     1141 apglgdflql hieqgkigvv fnigtvdisi keertpvndg kyhvvrftrn ggnatlqvdn
     1201 wpvnehyptg ntdnerfqmv kqkipfkynr pveewlqekg rqltifntqa qiaiggkdkg
     1261 rlfqgqlsgl yydglkvlnm aaennpniki ngsvrlvgev psilgttqtt smppemsttv
     1321 mettttmatt ttrknrstas iqptsddlvs saecssdded fvecepstgr sggelvipll
     1381 vedplatppi atrapsitlp ptfrplltii ettkdslsmt seaglpclsd qgsdgcdddg
     1441 lvisgygsge tfdsnlpptd dedfyttfsl vtdkslstsi feggykahap kweskdfrpn
     1501 kvsetsrttt tslspelirf tassssgmvp klpagkmnnr dlkpqpdivl lplptayeld
     1561 stklksplit spmfrnvpta nptepgirrv pgasevires ssttgmvvgi vaaaalcili
     1621 llyamykyrn rdegsyqvde trnyisnsaq sngtlmkekq qssksghkkq knkdreyyv
//
LOCUS       XP_047287895            1676 aa            linear   PRI 05-AUG-2025
DEFINITION  neurexin 3 isoform X5 [Homo sapiens].
ACCESSION   XP_047287895
VERSION     XP_047287895.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431939.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1676
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1676
                     /product="neurexin 3 isoform X5"
                     /calculated_mol_wt=184532
     Region          35..181
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          202..232
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          286..417
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          474..623
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          651..684
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          712..846
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          903..1031
                     /region_name="Laminin_G_2"
                     /note="Laminin G domain; pfam02210"
                     /db_xref="CDD:460494"
     Region          1095..1274
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          1602..1658
                     /region_name="Syndecan"
                     /note="Syndecan domain; pfam01034"
                     /db_xref="CDD:460035"
     Region          1622..1640
                     /region_name="4.1m"
                     /note="putative band 4.1 homologues' binding motif;
                     smart00294"
                     /db_xref="CDD:128590"
     CDS             1..1676
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /coded_by="XM_047431939.1:1006..6036"
                     /db_xref="GeneID:9369"
                     /db_xref="HGNC:HGNC:8010"
                     /db_xref="MIM:600567"
ORIGIN      
        1 msstlhsvff tlkvsillgs llglclglef mglpnqwary lrwdastrsd lsfqfktnvs
       61 tglllylddg gvcdflclsl vdgrvqlrfs mdcaetavls nkqvndsswh flmvsrdrlr
      121 tvlmldgegq sgelqpqrpy mdvvsdlflg gvptdirpsa ltldgvqamp gfkglildlk
      181 ygnseprllg srgvqmdaeg pcgerpceng gicflldghp tcdcsttgyg gklcsedvsq
      241 dpglshlmms eqgrskaree nvatfrgsey lcydlsqnpi qsssdeitls fktwqrngli
      301 lhtgksadyv nlalkdgavs lvinlgsgaf eaivepvngk fndnawhdvk vtrnlrqvti
      361 svdgiltttg ytqedytmlg sddffyvggs pstadlpgsp vsnnfmgclk evvyknndir
      421 lelsrlaria dtkmkiygev vfkcenvatl dpinfetpea yislpkwntk rmgsisfdfr
      481 ttepnglilf thgkpqerkd arsqkntkvd ffavelldgn lyllldmgsg tikvkatqkk
      541 andgewyhvd iqrdgrsgti svnsrrtpft asgeseildl egdmylgglp enraglilpt
      601 elwtamlnyg yvgcirdlfi dgrsknirql aemqnaagvk sscsrmsakq cdsypcknna
      661 vckdgwnrfi cdctgtgywg rtcereasil sydgsmymki impmvmhtea edvsfrfmsq
      721 raygllvatt srdsadtlrl eldggrvklm vnldcirinc nsskgpetly agqklndnew
      781 htvrvvrrgk slkltvdddv aegtmvgdht rlefhnietg imtekryisv vpssfighlq
      841 slmfngllyi dlckngdidy celkarfglr niiadpvtfk tkssylslat lqaytsmhlf
      901 fqfkttspdg filfnsgdgn dfiavelvkg yihyvfdlgn gpnvikgnsd rplndnqwhn
      961 vvitrdnsnt hslkvdtkvv tqvingaknl dlkgdlymag laqgmysnlp klvasrdgfq
     1021 gclasvdlng rlpdlindal hrsgqiergc egpsttcqed scanqgvcmq qwegftcdcs
     1081 mtsysgnqcn dpgatyifgk sgglilytwp andrpstrsd rlavgfsttv kdgilvrids
     1141 apglgdflql hieqgkigvv fnigtvdisi keertpvndg kyhvvrftrn ggnatlqvdn
     1201 wpvnehyptg ntdnerfqmv kqkipfkynr pveewlqekg rqltifntqa qiaiggkdkg
     1261 rlfqgqlsgl yydglkvlnm aaennpniki ngsvrlvgev psilgttqtt smppemsttv
     1321 mettttmatt ttrknrstas iqptsddlvs saecssdded fvecepstgg elvipllved
     1381 platppiatr apsitlpptf rplltiiett kdslsmtsea glpclsdqgs dgcdddglvi
     1441 sgygsgetfd snlpptdded fyttfslvtd kslstsifeg gykahapkwe skdfrpnkvs
     1501 etsrttttsl spelirftas sssgmvpklp agkmnnrdlk pqpdivllpl ptayeldstk
     1561 lksplitspm frnvptanpt epgirrvpga seviressst tgmvvgivaa aalcililly
     1621 amykyrnrde gsyqvdetrn yisnsaqsng tlmkekqqss ksghkkqknk dreyyv
//
LOCUS       XP_016877283            1675 aa            linear   PRI 05-AUG-2025
DEFINITION  neurexin 3 isoform X6 [Homo sapiens].
ACCESSION   XP_016877283
VERSION     XP_016877283.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021794.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1675
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1675
                     /product="neurexin 3 isoform X6"
                     /calculated_mol_wt=184404
     Region          35..181
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          202..232
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          282..413
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          470..619
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          647..680
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          708..842
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          899..1027
                     /region_name="Laminin_G_2"
                     /note="Laminin G domain; pfam02210"
                     /db_xref="CDD:460494"
     Region          1091..1270
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          1601..1657
                     /region_name="Syndecan"
                     /note="Syndecan domain; pfam01034"
                     /db_xref="CDD:460035"
     Region          1621..1639
                     /region_name="4.1m"
                     /note="putative band 4.1 homologues' binding motif;
                     smart00294"
                     /db_xref="CDD:128590"
     CDS             1..1675
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /coded_by="XM_017021794.2:1006..6033"
                     /db_xref="GeneID:9369"
                     /db_xref="HGNC:HGNC:8010"
                     /db_xref="MIM:600567"
ORIGIN      
        1 msstlhsvff tlkvsillgs llglclglef mglpnqwary lrwdastrsd lsfqfktnvs
       61 tglllylddg gvcdflclsl vdgrvqlrfs mdcaetavls nkqvndsswh flmvsrdrlr
      121 tvlmldgegq sgelqpqrpy mdvvsdlflg gvptdirpsa ltldgvqamp gfkglildlk
      181 ygnseprllg srgvqmdaeg pcgerpceng gicflldghp tcdcsttgyg gklcsedvsq
      241 dpglshlmms eqareenvat frgseylcyd lsqnpiqsss deitlsfktw qrnglilhtg
      301 ksadyvnlal kdgavslvin lgsgafeaiv epvngkfndn awhdvkvtrn lrqvtisvdg
      361 iltttgytqe dytmlgsddf fyvggspsta dlpgspvsnn fmgclkevvy knndirlels
      421 rlariadtkm kiygevvfkc envatldpin fetpeayisl pkwntkrmgs isfdfrttep
      481 nglilfthgk pqerkdarsq kntkvdffav elldgnlyll ldmgsgtikv katqkkandg
      541 ewyhvdiqrd grsgtisvns rrtpftasge seildlegdm ylgglpenra glilptelwt
      601 amlnygyvgc irdlfidgrs knirqlaemq naagvksscs rmsakqcdsy pcknnavckd
      661 gwnrficdct gtgywgrtce reasilsydg smymkiimpm vmhteaedvs frfmsqrayg
      721 llvattsrds adtlrleldg grvklmvnld cirincnssk gpetlyagqk lndnewhtvr
      781 vvrrgkslkl tvdddvaegt mvgdhtrlef hnietgimte kryisvvpss fighlqslmf
      841 ngllyidlck ngdidycelk arfglrniia dpvtfktkss ylslatlqay tsmhlffqfk
      901 ttspdgfilf nsgdgndfia velvkgyihy vfdlgngpnv ikgnsdrpln dnqwhnvvit
      961 rdnsnthslk vdtkvvtqvi ngaknldlkg dlymaglaqg mysnlpklva srdgfqgcla
     1021 svdlngrlpd lindalhrsg qiergcegps ttcqedscan qgvcmqqweg ftcdcsmtsy
     1081 sgnqcndpga tyifgksggl ilytwpandr pstrsdrlav gfsttvkdgi lvridsapgl
     1141 gdflqlhieq gkigvvfnig tvdisikeer tpvndgkyhv vrftrnggna tlqvdnwpvn
     1201 ehyptgntdn erfqmvkqki pfkynrpvee wlqekgrqlt ifntqaqiai ggkdkgrlfq
     1261 gqlsglyydg lkvlnmaaen npnikingsv rlvgevpsil gttqttsmpp emsttvmett
     1321 ttmattttrk nrstasiqpt sddlvssaec ssddedfvec epstgrsgge lvipllvedp
     1381 latppiatra psitlpptfr plltiiettk dslsmtseag lpclsdqgsd gcdddglvis
     1441 gygsgetfds nlpptddedf yttfslvtdk slstsifegg ykahapkwes kdfrpnkvse
     1501 tsrttttsls pelirftass ssgmvpklpa gkmnnrdlkp qpdivllplp tayeldstkl
     1561 ksplitspmf rnvptanpte pgirrvpgas eviressstt gmvvgivaaa alcilillya
     1621 mykyrnrdeg syqvdetrny isnsaqsngt lmkekqqssk sghkkqknkd reyyv
//
LOCUS       XP_047287896            1672 aa            linear   PRI 05-AUG-2025
DEFINITION  neurexin 3 isoform X7 [Homo sapiens].
ACCESSION   XP_047287896
VERSION     XP_047287896.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431940.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1672
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1672
                     /product="neurexin 3 isoform X7"
                     /calculated_mol_wt=184103
     Region          35..181
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          202..232
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          282..413
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          470..619
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          647..680
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          708..842
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          899..1027
                     /region_name="Laminin_G_2"
                     /note="Laminin G domain; pfam02210"
                     /db_xref="CDD:460494"
     Region          1091..1270
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          1598..1654
                     /region_name="Syndecan"
                     /note="Syndecan domain; pfam01034"
                     /db_xref="CDD:460035"
     Region          1618..1636
                     /region_name="4.1m"
                     /note="putative band 4.1 homologues' binding motif;
                     smart00294"
                     /db_xref="CDD:128590"
     CDS             1..1672
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /coded_by="XM_047431940.1:1006..6024"
                     /db_xref="GeneID:9369"
                     /db_xref="HGNC:HGNC:8010"
                     /db_xref="MIM:600567"
ORIGIN      
        1 msstlhsvff tlkvsillgs llglclglef mglpnqwary lrwdastrsd lsfqfktnvs
       61 tglllylddg gvcdflclsl vdgrvqlrfs mdcaetavls nkqvndsswh flmvsrdrlr
      121 tvlmldgegq sgelqpqrpy mdvvsdlflg gvptdirpsa ltldgvqamp gfkglildlk
      181 ygnseprllg srgvqmdaeg pcgerpceng gicflldghp tcdcsttgyg gklcsedvsq
      241 dpglshlmms eqareenvat frgseylcyd lsqnpiqsss deitlsfktw qrnglilhtg
      301 ksadyvnlal kdgavslvin lgsgafeaiv epvngkfndn awhdvkvtrn lrqvtisvdg
      361 iltttgytqe dytmlgsddf fyvggspsta dlpgspvsnn fmgclkevvy knndirlels
      421 rlariadtkm kiygevvfkc envatldpin fetpeayisl pkwntkrmgs isfdfrttep
      481 nglilfthgk pqerkdarsq kntkvdffav elldgnlyll ldmgsgtikv katqkkandg
      541 ewyhvdiqrd grsgtisvns rrtpftasge seildlegdm ylgglpenra glilptelwt
      601 amlnygyvgc irdlfidgrs knirqlaemq naagvksscs rmsakqcdsy pcknnavckd
      661 gwnrficdct gtgywgrtce reasilsydg smymkiimpm vmhteaedvs frfmsqrayg
      721 llvattsrds adtlrleldg grvklmvnld cirincnssk gpetlyagqk lndnewhtvr
      781 vvrrgkslkl tvdddvaegt mvgdhtrlef hnietgimte kryisvvpss fighlqslmf
      841 ngllyidlck ngdidycelk arfglrniia dpvtfktkss ylslatlqay tsmhlffqfk
      901 ttspdgfilf nsgdgndfia velvkgyihy vfdlgngpnv ikgnsdrpln dnqwhnvvit
      961 rdnsnthslk vdtkvvtqvi ngaknldlkg dlymaglaqg mysnlpklva srdgfqgcla
     1021 svdlngrlpd lindalhrsg qiergcegps ttcqedscan qgvcmqqweg ftcdcsmtsy
     1081 sgnqcndpga tyifgksggl ilytwpandr pstrsdrlav gfsttvkdgi lvridsapgl
     1141 gdflqlhieq gkigvvfnig tvdisikeer tpvndgkyhv vrftrnggna tlqvdnwpvn
     1201 ehyptgntdn erfqmvkqki pfkynrpvee wlqekgrqlt ifntqaqiai ggkdkgrlfq
     1261 gqlsglyydg lkvlnmaaen npnikingsv rlvgevpsil gttqttsmpp emsttvmett
     1321 ttmattttrk nrstasiqpt sddlvssaec ssddedfvec epstggelvi pllvedplat
     1381 ppiatrapsi tlpptfrpll tiiettkdsl smtseaglpc lsdqgsdgcd ddglvisgyg
     1441 sgetfdsnlp ptddedfytt fslvtdksls tsifeggyka hapkweskdf rpnkvsetsr
     1501 ttttslspel irftassssg mvpklpagkm nnrdlkpqpd ivllplptay eldstklksp
     1561 litspmfrnv ptanptepgi rrvpgasevi resssttgmv vgivaaaalc ilillyamyk
     1621 yrnrdegsyq vdetrnyisn saqsngtlmk ekqqssksgh kkqknkdrey yv
//
LOCUS       XP_016877287            1666 aa            linear   PRI 05-AUG-2025
DEFINITION  neurexin 3 isoform X8 [Homo sapiens].
ACCESSION   XP_016877287
VERSION     XP_016877287.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021798.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1666
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1666
                     /product="neurexin 3 isoform X8"
                     /calculated_mol_wt=183354
     Region          35..181
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          202..232
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          282..413
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          470..619
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          647..680
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          708..833
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          890..1018
                     /region_name="Laminin_G_2"
                     /note="Laminin G domain; pfam02210"
                     /db_xref="CDD:460494"
     Region          1082..1261
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          1592..1648
                     /region_name="Syndecan"
                     /note="Syndecan domain; pfam01034"
                     /db_xref="CDD:460035"
     Region          1612..1630
                     /region_name="4.1m"
                     /note="putative band 4.1 homologues' binding motif;
                     smart00294"
                     /db_xref="CDD:128590"
     CDS             1..1666
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /coded_by="XM_017021798.2:1006..6006"
                     /db_xref="GeneID:9369"
                     /db_xref="HGNC:HGNC:8010"
                     /db_xref="MIM:600567"
ORIGIN      
        1 msstlhsvff tlkvsillgs llglclglef mglpnqwary lrwdastrsd lsfqfktnvs
       61 tglllylddg gvcdflclsl vdgrvqlrfs mdcaetavls nkqvndsswh flmvsrdrlr
      121 tvlmldgegq sgelqpqrpy mdvvsdlflg gvptdirpsa ltldgvqamp gfkglildlk
      181 ygnseprllg srgvqmdaeg pcgerpceng gicflldghp tcdcsttgyg gklcsedvsq
      241 dpglshlmms eqareenvat frgseylcyd lsqnpiqsss deitlsfktw qrnglilhtg
      301 ksadyvnlal kdgavslvin lgsgafeaiv epvngkfndn awhdvkvtrn lrqvtisvdg
      361 iltttgytqe dytmlgsddf fyvggspsta dlpgspvsnn fmgclkevvy knndirlels
      421 rlariadtkm kiygevvfkc envatldpin fetpeayisl pkwntkrmgs isfdfrttep
      481 nglilfthgk pqerkdarsq kntkvdffav elldgnlyll ldmgsgtikv katqkkandg
      541 ewyhvdiqrd grsgtisvns rrtpftasge seildlegdm ylgglpenra glilptelwt
      601 amlnygyvgc irdlfidgrs knirqlaemq naagvksscs rmsakqcdsy pcknnavckd
      661 gwnrficdct gtgywgrtce reasilsydg smymkiimpm vmhteaedvs frfmsqrayg
      721 llvattsrds adtlrleldg grvklmvnlg kgpetlyagq klndnewhtv rvvrrgkslk
      781 ltvdddvaeg tmvgdhtrle fhnietgimt ekryisvvps sfighlqslm fngllyidlc
      841 kngdidycel karfglrnii adpvtfktks sylslatlqa ytsmhlffqf kttspdgfil
      901 fnsgdgndfi avelvkgyih yvfdlgngpn vikgnsdrpl ndnqwhnvvi trdnsnthsl
      961 kvdtkvvtqv ingaknldlk gdlymaglaq gmysnlpklv asrdgfqgcl asvdlngrlp
     1021 dlindalhrs gqiergcegp sttcqedsca nqgvcmqqwe gftcdcsmts ysgnqcndpg
     1081 atyifgksgg lilytwpand rpstrsdrla vgfsttvkdg ilvridsapg lgdflqlhie
     1141 qgkigvvfni gtvdisikee rtpvndgkyh vvrftrnggn atlqvdnwpv nehyptgntd
     1201 nerfqmvkqk ipfkynrpve ewlqekgrql tifntqaqia iggkdkgrlf qgqlsglyyd
     1261 glkvlnmaae nnpnikings vrlvgevpsi lgttqttsmp pemsttvmet tttmattttr
     1321 knrstasiqp tsddlvssae cssddedfve cepstgrsgg elvipllved platppiatr
     1381 apsitlpptf rplltiiett kdslsmtsea glpclsdqgs dgcdddglvi sgygsgetfd
     1441 snlpptdded fyttfslvtd kslstsifeg gykahapkwe skdfrpnkvs etsrttttsl
     1501 spelirftas sssgmvpklp agkmnnrdlk pqpdivllpl ptayeldstk lksplitspm
     1561 frnvptanpt epgirrvpga seviressst tgmvvgivaa aalcililly amykyrnrde
     1621 gsyqvdetrn yisnsaqsng tlmkekqqss ksghkkqknk dreyyv
//
LOCUS       XP_047287897            1663 aa            linear   PRI 05-AUG-2025
DEFINITION  neurexin 3 isoform X9 [Homo sapiens].
ACCESSION   XP_047287897
VERSION     XP_047287897.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431941.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1663
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1663
                     /product="neurexin 3 isoform X9"
                     /calculated_mol_wt=183054
     Region          35..181
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          202..232
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          282..413
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          470..619
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          647..680
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          708..833
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          890..1018
                     /region_name="Laminin_G_2"
                     /note="Laminin G domain; pfam02210"
                     /db_xref="CDD:460494"
     Region          1082..1261
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          1589..1645
                     /region_name="Syndecan"
                     /note="Syndecan domain; pfam01034"
                     /db_xref="CDD:460035"
     Region          1609..1627
                     /region_name="4.1m"
                     /note="putative band 4.1 homologues' binding motif;
                     smart00294"
                     /db_xref="CDD:128590"
     CDS             1..1663
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /coded_by="XM_047431941.1:1006..5997"
                     /db_xref="GeneID:9369"
                     /db_xref="HGNC:HGNC:8010"
                     /db_xref="MIM:600567"
ORIGIN      
        1 msstlhsvff tlkvsillgs llglclglef mglpnqwary lrwdastrsd lsfqfktnvs
       61 tglllylddg gvcdflclsl vdgrvqlrfs mdcaetavls nkqvndsswh flmvsrdrlr
      121 tvlmldgegq sgelqpqrpy mdvvsdlflg gvptdirpsa ltldgvqamp gfkglildlk
      181 ygnseprllg srgvqmdaeg pcgerpceng gicflldghp tcdcsttgyg gklcsedvsq
      241 dpglshlmms eqareenvat frgseylcyd lsqnpiqsss deitlsfktw qrnglilhtg
      301 ksadyvnlal kdgavslvin lgsgafeaiv epvngkfndn awhdvkvtrn lrqvtisvdg
      361 iltttgytqe dytmlgsddf fyvggspsta dlpgspvsnn fmgclkevvy knndirlels
      421 rlariadtkm kiygevvfkc envatldpin fetpeayisl pkwntkrmgs isfdfrttep
      481 nglilfthgk pqerkdarsq kntkvdffav elldgnlyll ldmgsgtikv katqkkandg
      541 ewyhvdiqrd grsgtisvns rrtpftasge seildlegdm ylgglpenra glilptelwt
      601 amlnygyvgc irdlfidgrs knirqlaemq naagvksscs rmsakqcdsy pcknnavckd
      661 gwnrficdct gtgywgrtce reasilsydg smymkiimpm vmhteaedvs frfmsqrayg
      721 llvattsrds adtlrleldg grvklmvnlg kgpetlyagq klndnewhtv rvvrrgkslk
      781 ltvdddvaeg tmvgdhtrle fhnietgimt ekryisvvps sfighlqslm fngllyidlc
      841 kngdidycel karfglrnii adpvtfktks sylslatlqa ytsmhlffqf kttspdgfil
      901 fnsgdgndfi avelvkgyih yvfdlgngpn vikgnsdrpl ndnqwhnvvi trdnsnthsl
      961 kvdtkvvtqv ingaknldlk gdlymaglaq gmysnlpklv asrdgfqgcl asvdlngrlp
     1021 dlindalhrs gqiergcegp sttcqedsca nqgvcmqqwe gftcdcsmts ysgnqcndpg
     1081 atyifgksgg lilytwpand rpstrsdrla vgfsttvkdg ilvridsapg lgdflqlhie
     1141 qgkigvvfni gtvdisikee rtpvndgkyh vvrftrnggn atlqvdnwpv nehyptgntd
     1201 nerfqmvkqk ipfkynrpve ewlqekgrql tifntqaqia iggkdkgrlf qgqlsglyyd
     1261 glkvlnmaae nnpnikings vrlvgevpsi lgttqttsmp pemsttvmet tttmattttr
     1321 knrstasiqp tsddlvssae cssddedfve cepstggelv ipllvedpla tppiatraps
     1381 itlpptfrpl ltiiettkds lsmtseaglp clsdqgsdgc dddglvisgy gsgetfdsnl
     1441 pptddedfyt tfslvtdksl stsifeggyk ahapkweskd frpnkvsets rttttslspe
     1501 lirftassss gmvpklpagk mnnrdlkpqp divllplpta yeldstklks plitspmfrn
     1561 vptanptepg irrvpgasev iresssttgm vvgivaaaal cilillyamy kyrnrdegsy
     1621 qvdetrnyis nsaqsngtlm kekqqssksg hkkqknkdre yyv
//
LOCUS       XP_016877288            1654 aa            linear   PRI 05-AUG-2025
DEFINITION  neurexin 3 isoform X10 [Homo sapiens].
ACCESSION   XP_016877288
VERSION     XP_016877288.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021799.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1654
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1654
                     /product="neurexin 3 isoform X10"
                     /calculated_mol_wt=181587
     Region          35..181
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          202..232
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          286..425
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          482..631
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          659..692
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          720..854
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          911..1039
                     /region_name="Laminin_G_2"
                     /note="Laminin G domain; pfam02210"
                     /db_xref="CDD:460494"
     Region          1103..1252
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          1580..1636
                     /region_name="Syndecan"
                     /note="Syndecan domain; pfam01034"
                     /db_xref="CDD:460035"
     Region          1600..1618
                     /region_name="4.1m"
                     /note="putative band 4.1 homologues' binding motif;
                     smart00294"
                     /db_xref="CDD:128590"
     CDS             1..1654
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /coded_by="XM_017021799.3:1006..5970"
                     /db_xref="GeneID:9369"
                     /db_xref="HGNC:HGNC:8010"
                     /db_xref="MIM:600567"
ORIGIN      
        1 msstlhsvff tlkvsillgs llglclglef mglpnqwary lrwdastrsd lsfqfktnvs
       61 tglllylddg gvcdflclsl vdgrvqlrfs mdcaetavls nkqvndsswh flmvsrdrlr
      121 tvlmldgegq sgelqpqrpy mdvvsdlflg gvptdirpsa ltldgvqamp gfkglildlk
      181 ygnseprllg srgvqmdaeg pcgerpceng gicflldghp tcdcsttgyg gklcsedvsq
      241 dpglshlmms eqgrskaree nvatfrgsey lcydlsqnpi qsssdeitls fktwqrngli
      301 lhtgksadyv nlalkdgavs lvinlgsgaf eaivepvngk fndnawhdvk vtrnlrqhsg
      361 ighamvtisv dgiltttgyt qedytmlgsd dffyvggsps tadlpgspvs nnfmgclkev
      421 vyknndirle lsrlariadt kmkiygevvf kcenvatldp infetpeayi slpkwntkrm
      481 gsisfdfrtt epnglilfth gkpqerkdar sqkntkvdff avelldgnly llldmgsgti
      541 kvkatqkkan dgewyhvdiq rdgrsgtisv nsrrtpftas geseildleg dmylgglpen
      601 raglilptel wtamlnygyv gcirdlfidg rsknirqlae mqnaagvkss csrmsakqcd
      661 sypcknnavc kdgwnrficd ctgtgywgrt cereasilsy dgsmymkiim pmvmhteaed
      721 vsfrfmsqra ygllvattsr dsadtlrlel dggrvklmvn ldcirincns skgpetlyag
      781 qklndnewht vrvvrrgksl kltvdddvae gtmvgdhtrl efhnietgim tekryisvvp
      841 ssfighlqsl mfngllyidl ckngdidyce lkarfglrni iadpvtfktk ssylslatlq
      901 aytsmhlffq fkttspdgfi lfnsgdgndf iavelvkgyi hyvfdlgngp nvikgnsdrp
      961 lndnqwhnvv itrdnsnths lkvdtkvvtq vingaknldl kgdlymagla qgmysnlpkl
     1021 vasrdgfqgc lasvdlngrl pdlindalhr sgqiergceg psttcqedsc anqgvcmqqw
     1081 egftcdcsmt sysgnqcndp gatyifgksg glilytwpan drpstrsdrl avgfsttvkd
     1141 gilvridsap glgdflqlhi eqgkigvvfn igtvdisike ertpvndgky hvvrftrngg
     1201 natlqvdnwp vnehyptgrq ltifntqaqi aiggkdkgrl fqgqlsglyy dglkvlnmaa
     1261 ennpniking svrlvgevps ilgttqttsm ppemsttvme ttttmatttt rknrstasiq
     1321 ptsddlvssa ecssddedfv ecepstggel vipllvedpl atppiatrap sitlpptfrp
     1381 lltiiettkd slsmtseagl pclsdqgsdg cdddglvisg ygsgetfdsn lpptddedfy
     1441 ttfslvtdks lstsifeggy kahapkwesk dfrpnkvset srttttslsp elirftasss
     1501 sgmvpklpag kmnnrdlkpq pdivllplpt ayeldstklk splitspmfr nvptanptep
     1561 girrvpgase viresssttg mvvgivaaaa lcilillyam ykyrnrdegs yqvdetrnyi
     1621 snsaqsngtl mkekqqssks ghkkqknkdr eyyv
//
LOCUS       XP_047287898            1645 aa            linear   PRI 05-AUG-2025
DEFINITION  neurexin 3 isoform X11 [Homo sapiens].
ACCESSION   XP_047287898
VERSION     XP_047287898.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431942.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1645
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1645
                     /product="neurexin 3 isoform X11"
                     /calculated_mol_wt=180668
     Region          35..181
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          202..232
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          282..413
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          470..619
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          647..680
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          708..842
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          899..1027
                     /region_name="Laminin_G_2"
                     /note="Laminin G domain; pfam02210"
                     /db_xref="CDD:460494"
     Region          1091..1240
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          1571..1627
                     /region_name="Syndecan"
                     /note="Syndecan domain; pfam01034"
                     /db_xref="CDD:460035"
     Region          1591..1609
                     /region_name="4.1m"
                     /note="putative band 4.1 homologues' binding motif;
                     smart00294"
                     /db_xref="CDD:128590"
     CDS             1..1645
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /coded_by="XM_047431942.1:1006..5943"
                     /db_xref="GeneID:9369"
                     /db_xref="HGNC:HGNC:8010"
                     /db_xref="MIM:600567"
ORIGIN      
        1 msstlhsvff tlkvsillgs llglclglef mglpnqwary lrwdastrsd lsfqfktnvs
       61 tglllylddg gvcdflclsl vdgrvqlrfs mdcaetavls nkqvndsswh flmvsrdrlr
      121 tvlmldgegq sgelqpqrpy mdvvsdlflg gvptdirpsa ltldgvqamp gfkglildlk
      181 ygnseprllg srgvqmdaeg pcgerpceng gicflldghp tcdcsttgyg gklcsedvsq
      241 dpglshlmms eqareenvat frgseylcyd lsqnpiqsss deitlsfktw qrnglilhtg
      301 ksadyvnlal kdgavslvin lgsgafeaiv epvngkfndn awhdvkvtrn lrqvtisvdg
      361 iltttgytqe dytmlgsddf fyvggspsta dlpgspvsnn fmgclkevvy knndirlels
      421 rlariadtkm kiygevvfkc envatldpin fetpeayisl pkwntkrmgs isfdfrttep
      481 nglilfthgk pqerkdarsq kntkvdffav elldgnlyll ldmgsgtikv katqkkandg
      541 ewyhvdiqrd grsgtisvns rrtpftasge seildlegdm ylgglpenra glilptelwt
      601 amlnygyvgc irdlfidgrs knirqlaemq naagvksscs rmsakqcdsy pcknnavckd
      661 gwnrficdct gtgywgrtce reasilsydg smymkiimpm vmhteaedvs frfmsqrayg
      721 llvattsrds adtlrleldg grvklmvnld cirincnssk gpetlyagqk lndnewhtvr
      781 vvrrgkslkl tvdddvaegt mvgdhtrlef hnietgimte kryisvvpss fighlqslmf
      841 ngllyidlck ngdidycelk arfglrniia dpvtfktkss ylslatlqay tsmhlffqfk
      901 ttspdgfilf nsgdgndfia velvkgyihy vfdlgngpnv ikgnsdrpln dnqwhnvvit
      961 rdnsnthslk vdtkvvtqvi ngaknldlkg dlymaglaqg mysnlpklva srdgfqgcla
     1021 svdlngrlpd lindalhrsg qiergcegps ttcqedscan qgvcmqqweg ftcdcsmtsy
     1081 sgnqcndpga tyifgksggl ilytwpandr pstrsdrlav gfsttvkdgi lvridsapgl
     1141 gdflqlhieq gkigvvfnig tvdisikeer tpvndgkyhv vrftrnggna tlqvdnwpvn
     1201 ehyptgrqlt ifntqaqiai ggkdkgrlfq gqlsglyydg lkvlnmaaen npnikingsv
     1261 rlvgevpsil gttqttsmpp emsttvmett ttmattttrk nrstasiqpt sddlvssaec
     1321 ssddedfvec epstgrsgge lvipllvedp latppiatra psitlpptfr plltiiettk
     1381 dslsmtseag lpclsdqgsd gcdddglvis gygsgetfds nlpptddedf yttfslvtdk
     1441 slstsifegg ykahapkwes kdfrpnkvse tsrttttsls pelirftass ssgmvpklpa
     1501 gkmnnrdlkp qpdivllplp tayeldstkl ksplitspmf rnvptanpte pgirrvpgas
     1561 eviressstt gmvvgivaaa alcilillya mykyrnrdeg syqvdetrny isnsaqsngt
     1621 lmkekqqssk sghkkqknkd reyyv
//
LOCUS       XP_047287899            1642 aa            linear   PRI 05-AUG-2025
DEFINITION  neurexin 3 isoform X12 [Homo sapiens].
ACCESSION   XP_047287899
VERSION     XP_047287899.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431943.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1642
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1642
                     /product="neurexin 3 isoform X12"
                     /calculated_mol_wt=180368
     Region          35..181
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          202..232
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          282..413
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          470..619
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          647..680
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          708..842
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          899..1027
                     /region_name="Laminin_G_2"
                     /note="Laminin G domain; pfam02210"
                     /db_xref="CDD:460494"
     Region          1091..1240
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          1568..1624
                     /region_name="Syndecan"
                     /note="Syndecan domain; pfam01034"
                     /db_xref="CDD:460035"
     Region          1588..1606
                     /region_name="4.1m"
                     /note="putative band 4.1 homologues' binding motif;
                     smart00294"
                     /db_xref="CDD:128590"
     CDS             1..1642
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /coded_by="XM_047431943.1:1006..5934"
                     /db_xref="GeneID:9369"
                     /db_xref="HGNC:HGNC:8010"
                     /db_xref="MIM:600567"
ORIGIN      
        1 msstlhsvff tlkvsillgs llglclglef mglpnqwary lrwdastrsd lsfqfktnvs
       61 tglllylddg gvcdflclsl vdgrvqlrfs mdcaetavls nkqvndsswh flmvsrdrlr
      121 tvlmldgegq sgelqpqrpy mdvvsdlflg gvptdirpsa ltldgvqamp gfkglildlk
      181 ygnseprllg srgvqmdaeg pcgerpceng gicflldghp tcdcsttgyg gklcsedvsq
      241 dpglshlmms eqareenvat frgseylcyd lsqnpiqsss deitlsfktw qrnglilhtg
      301 ksadyvnlal kdgavslvin lgsgafeaiv epvngkfndn awhdvkvtrn lrqvtisvdg
      361 iltttgytqe dytmlgsddf fyvggspsta dlpgspvsnn fmgclkevvy knndirlels
      421 rlariadtkm kiygevvfkc envatldpin fetpeayisl pkwntkrmgs isfdfrttep
      481 nglilfthgk pqerkdarsq kntkvdffav elldgnlyll ldmgsgtikv katqkkandg
      541 ewyhvdiqrd grsgtisvns rrtpftasge seildlegdm ylgglpenra glilptelwt
      601 amlnygyvgc irdlfidgrs knirqlaemq naagvksscs rmsakqcdsy pcknnavckd
      661 gwnrficdct gtgywgrtce reasilsydg smymkiimpm vmhteaedvs frfmsqrayg
      721 llvattsrds adtlrleldg grvklmvnld cirincnssk gpetlyagqk lndnewhtvr
      781 vvrrgkslkl tvdddvaegt mvgdhtrlef hnietgimte kryisvvpss fighlqslmf
      841 ngllyidlck ngdidycelk arfglrniia dpvtfktkss ylslatlqay tsmhlffqfk
      901 ttspdgfilf nsgdgndfia velvkgyihy vfdlgngpnv ikgnsdrpln dnqwhnvvit
      961 rdnsnthslk vdtkvvtqvi ngaknldlkg dlymaglaqg mysnlpklva srdgfqgcla
     1021 svdlngrlpd lindalhrsg qiergcegps ttcqedscan qgvcmqqweg ftcdcsmtsy
     1081 sgnqcndpga tyifgksggl ilytwpandr pstrsdrlav gfsttvkdgi lvridsapgl
     1141 gdflqlhieq gkigvvfnig tvdisikeer tpvndgkyhv vrftrnggna tlqvdnwpvn
     1201 ehyptgrqlt ifntqaqiai ggkdkgrlfq gqlsglyydg lkvlnmaaen npnikingsv
     1261 rlvgevpsil gttqttsmpp emsttvmett ttmattttrk nrstasiqpt sddlvssaec
     1321 ssddedfvec epstggelvi pllvedplat ppiatrapsi tlpptfrpll tiiettkdsl
     1381 smtseaglpc lsdqgsdgcd ddglvisgyg sgetfdsnlp ptddedfytt fslvtdksls
     1441 tsifeggyka hapkweskdf rpnkvsetsr ttttslspel irftassssg mvpklpagkm
     1501 nnrdlkpqpd ivllplptay eldstklksp litspmfrnv ptanptepgi rrvpgasevi
     1561 resssttgmv vgivaaaalc ilillyamyk yrnrdegsyq vdetrnyisn saqsngtlmk
     1621 ekqqssksgh kkqknkdrey yv
//
LOCUS       XP_024305519            1636 aa            linear   PRI 05-AUG-2025
DEFINITION  neurexin 3 isoform X13 [Homo sapiens].
ACCESSION   XP_024305519
VERSION     XP_024305519.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449751.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1636
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1636
                     /product="neurexin 3 isoform X13"
                     /calculated_mol_wt=179619
     Region          35..181
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          202..232
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          282..413
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          470..619
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          647..680
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          708..833
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          890..1018
                     /region_name="Laminin_G_2"
                     /note="Laminin G domain; pfam02210"
                     /db_xref="CDD:460494"
     Region          1082..1231
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          1562..1618
                     /region_name="Syndecan"
                     /note="Syndecan domain; pfam01034"
                     /db_xref="CDD:460035"
     Region          1582..1600
                     /region_name="4.1m"
                     /note="putative band 4.1 homologues' binding motif;
                     smart00294"
                     /db_xref="CDD:128590"
     CDS             1..1636
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /coded_by="XM_024449751.2:1006..5916"
                     /db_xref="GeneID:9369"
                     /db_xref="HGNC:HGNC:8010"
                     /db_xref="MIM:600567"
ORIGIN      
        1 msstlhsvff tlkvsillgs llglclglef mglpnqwary lrwdastrsd lsfqfktnvs
       61 tglllylddg gvcdflclsl vdgrvqlrfs mdcaetavls nkqvndsswh flmvsrdrlr
      121 tvlmldgegq sgelqpqrpy mdvvsdlflg gvptdirpsa ltldgvqamp gfkglildlk
      181 ygnseprllg srgvqmdaeg pcgerpceng gicflldghp tcdcsttgyg gklcsedvsq
      241 dpglshlmms eqareenvat frgseylcyd lsqnpiqsss deitlsfktw qrnglilhtg
      301 ksadyvnlal kdgavslvin lgsgafeaiv epvngkfndn awhdvkvtrn lrqvtisvdg
      361 iltttgytqe dytmlgsddf fyvggspsta dlpgspvsnn fmgclkevvy knndirlels
      421 rlariadtkm kiygevvfkc envatldpin fetpeayisl pkwntkrmgs isfdfrttep
      481 nglilfthgk pqerkdarsq kntkvdffav elldgnlyll ldmgsgtikv katqkkandg
      541 ewyhvdiqrd grsgtisvns rrtpftasge seildlegdm ylgglpenra glilptelwt
      601 amlnygyvgc irdlfidgrs knirqlaemq naagvksscs rmsakqcdsy pcknnavckd
      661 gwnrficdct gtgywgrtce reasilsydg smymkiimpm vmhteaedvs frfmsqrayg
      721 llvattsrds adtlrleldg grvklmvnlg kgpetlyagq klndnewhtv rvvrrgkslk
      781 ltvdddvaeg tmvgdhtrle fhnietgimt ekryisvvps sfighlqslm fngllyidlc
      841 kngdidycel karfglrnii adpvtfktks sylslatlqa ytsmhlffqf kttspdgfil
      901 fnsgdgndfi avelvkgyih yvfdlgngpn vikgnsdrpl ndnqwhnvvi trdnsnthsl
      961 kvdtkvvtqv ingaknldlk gdlymaglaq gmysnlpklv asrdgfqgcl asvdlngrlp
     1021 dlindalhrs gqiergcegp sttcqedsca nqgvcmqqwe gftcdcsmts ysgnqcndpg
     1081 atyifgksgg lilytwpand rpstrsdrla vgfsttvkdg ilvridsapg lgdflqlhie
     1141 qgkigvvfni gtvdisikee rtpvndgkyh vvrftrnggn atlqvdnwpv nehyptgrql
     1201 tifntqaqia iggkdkgrlf qgqlsglyyd glkvlnmaae nnpnikings vrlvgevpsi
     1261 lgttqttsmp pemsttvmet tttmattttr knrstasiqp tsddlvssae cssddedfve
     1321 cepstgrsgg elvipllved platppiatr apsitlpptf rplltiiett kdslsmtsea
     1381 glpclsdqgs dgcdddglvi sgygsgetfd snlpptdded fyttfslvtd kslstsifeg
     1441 gykahapkwe skdfrpnkvs etsrttttsl spelirftas sssgmvpklp agkmnnrdlk
     1501 pqpdivllpl ptayeldstk lksplitspm frnvptanpt epgirrvpga seviressst
     1561 tgmvvgivaa aalcililly amykyrnrde gsyqvdetrn yisnsaqsng tlmkekqqss
     1621 ksghkkqknk dreyyv
//
LOCUS       XP_047287900            1633 aa            linear   PRI 05-AUG-2025
DEFINITION  neurexin 3 isoform X14 [Homo sapiens].
ACCESSION   XP_047287900
VERSION     XP_047287900.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431944.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1633
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1633
                     /product="neurexin 3 isoform X14"
                     /calculated_mol_wt=179319
     Region          35..181
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          202..232
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          282..413
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          470..619
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          647..680
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          708..833
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          890..1018
                     /region_name="Laminin_G_2"
                     /note="Laminin G domain; pfam02210"
                     /db_xref="CDD:460494"
     Region          1082..1231
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          1559..1615
                     /region_name="Syndecan"
                     /note="Syndecan domain; pfam01034"
                     /db_xref="CDD:460035"
     Region          1579..1597
                     /region_name="4.1m"
                     /note="putative band 4.1 homologues' binding motif;
                     smart00294"
                     /db_xref="CDD:128590"
     CDS             1..1633
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /coded_by="XM_047431944.1:1006..5907"
                     /db_xref="GeneID:9369"
                     /db_xref="HGNC:HGNC:8010"
                     /db_xref="MIM:600567"
ORIGIN      
        1 msstlhsvff tlkvsillgs llglclglef mglpnqwary lrwdastrsd lsfqfktnvs
       61 tglllylddg gvcdflclsl vdgrvqlrfs mdcaetavls nkqvndsswh flmvsrdrlr
      121 tvlmldgegq sgelqpqrpy mdvvsdlflg gvptdirpsa ltldgvqamp gfkglildlk
      181 ygnseprllg srgvqmdaeg pcgerpceng gicflldghp tcdcsttgyg gklcsedvsq
      241 dpglshlmms eqareenvat frgseylcyd lsqnpiqsss deitlsfktw qrnglilhtg
      301 ksadyvnlal kdgavslvin lgsgafeaiv epvngkfndn awhdvkvtrn lrqvtisvdg
      361 iltttgytqe dytmlgsddf fyvggspsta dlpgspvsnn fmgclkevvy knndirlels
      421 rlariadtkm kiygevvfkc envatldpin fetpeayisl pkwntkrmgs isfdfrttep
      481 nglilfthgk pqerkdarsq kntkvdffav elldgnlyll ldmgsgtikv katqkkandg
      541 ewyhvdiqrd grsgtisvns rrtpftasge seildlegdm ylgglpenra glilptelwt
      601 amlnygyvgc irdlfidgrs knirqlaemq naagvksscs rmsakqcdsy pcknnavckd
      661 gwnrficdct gtgywgrtce reasilsydg smymkiimpm vmhteaedvs frfmsqrayg
      721 llvattsrds adtlrleldg grvklmvnlg kgpetlyagq klndnewhtv rvvrrgkslk
      781 ltvdddvaeg tmvgdhtrle fhnietgimt ekryisvvps sfighlqslm fngllyidlc
      841 kngdidycel karfglrnii adpvtfktks sylslatlqa ytsmhlffqf kttspdgfil
      901 fnsgdgndfi avelvkgyih yvfdlgngpn vikgnsdrpl ndnqwhnvvi trdnsnthsl
      961 kvdtkvvtqv ingaknldlk gdlymaglaq gmysnlpklv asrdgfqgcl asvdlngrlp
     1021 dlindalhrs gqiergcegp sttcqedsca nqgvcmqqwe gftcdcsmts ysgnqcndpg
     1081 atyifgksgg lilytwpand rpstrsdrla vgfsttvkdg ilvridsapg lgdflqlhie
     1141 qgkigvvfni gtvdisikee rtpvndgkyh vvrftrnggn atlqvdnwpv nehyptgrql
     1201 tifntqaqia iggkdkgrlf qgqlsglyyd glkvlnmaae nnpnikings vrlvgevpsi
     1261 lgttqttsmp pemsttvmet tttmattttr knrstasiqp tsddlvssae cssddedfve
     1321 cepstggelv ipllvedpla tppiatraps itlpptfrpl ltiiettkds lsmtseaglp
     1381 clsdqgsdgc dddglvisgy gsgetfdsnl pptddedfyt tfslvtdksl stsifeggyk
     1441 ahapkweskd frpnkvsets rttttslspe lirftassss gmvpklpagk mnnrdlkpqp
     1501 divllplpta yeldstklks plitspmfrn vptanptepg irrvpgasev iresssttgm
     1561 vvgivaaaal cilillyamy kyrnrdegsy qvdetrnyis nsaqsngtlm kekqqssksg
     1621 hkkqknkdre yyv
//
LOCUS       XP_011535670            1586 aa            linear   PRI 05-AUG-2025
DEFINITION  neurexin 3 isoform X15 [Homo sapiens].
ACCESSION   XP_011535670
VERSION     XP_011535670.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537368.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1586
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1586
                     /product="neurexin 3 isoform X15"
                     /calculated_mol_wt=175049
     Region          35..181
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          202..232
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          286..425
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          482..631
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          659..692
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          720..854
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          911..1039
                     /region_name="Laminin_G_2"
                     /note="Laminin G domain; pfam02210"
                     /db_xref="CDD:460494"
     Region          1103..1282
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          1512..1568
                     /region_name="Syndecan"
                     /note="Syndecan domain; pfam01034"
                     /db_xref="CDD:460035"
     Region          1532..1550
                     /region_name="4.1m"
                     /note="putative band 4.1 homologues' binding motif;
                     smart00294"
                     /db_xref="CDD:128590"
     CDS             1..1586
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /coded_by="XM_011537368.2:1006..5766"
                     /db_xref="GeneID:9369"
                     /db_xref="HGNC:HGNC:8010"
                     /db_xref="MIM:600567"
ORIGIN      
        1 msstlhsvff tlkvsillgs llglclglef mglpnqwary lrwdastrsd lsfqfktnvs
       61 tglllylddg gvcdflclsl vdgrvqlrfs mdcaetavls nkqvndsswh flmvsrdrlr
      121 tvlmldgegq sgelqpqrpy mdvvsdlflg gvptdirpsa ltldgvqamp gfkglildlk
      181 ygnseprllg srgvqmdaeg pcgerpceng gicflldghp tcdcsttgyg gklcsedvsq
      241 dpglshlmms eqgrskaree nvatfrgsey lcydlsqnpi qsssdeitls fktwqrngli
      301 lhtgksadyv nlalkdgavs lvinlgsgaf eaivepvngk fndnawhdvk vtrnlrqhsg
      361 ighamvtisv dgiltttgyt qedytmlgsd dffyvggsps tadlpgspvs nnfmgclkev
      421 vyknndirle lsrlariadt kmkiygevvf kcenvatldp infetpeayi slpkwntkrm
      481 gsisfdfrtt epnglilfth gkpqerkdar sqkntkvdff avelldgnly llldmgsgti
      541 kvkatqkkan dgewyhvdiq rdgrsgtisv nsrrtpftas geseildleg dmylgglpen
      601 raglilptel wtamlnygyv gcirdlfidg rsknirqlae mqnaagvkss csrmsakqcd
      661 sypcknnavc kdgwnrficd ctgtgywgrt cereasilsy dgsmymkiim pmvmhteaed
      721 vsfrfmsqra ygllvattsr dsadtlrlel dggrvklmvn ldcirincns skgpetlyag
      781 qklndnewht vrvvrrgksl kltvdddvae gtmvgdhtrl efhnietgim tekryisvvp
      841 ssfighlqsl mfngllyidl ckngdidyce lkarfglrni iadpvtfktk ssylslatlq
      901 aytsmhlffq fkttspdgfi lfnsgdgndf iavelvkgyi hyvfdlgngp nvikgnsdrp
      961 lndnqwhnvv itrdnsnths lkvdtkvvtq vingaknldl kgdlymagla qgmysnlpkl
     1021 vasrdgfqgc lasvdlngrl pdlindalhr sgqiergceg psttcqedsc anqgvcmqqw
     1081 egftcdcsmt sysgnqcndp gatyifgksg glilytwpan drpstrsdrl avgfsttvkd
     1141 gilvridsap glgdflqlhi eqgkigvvfn igtvdisike ertpvndgky hvvrftrngg
     1201 natlqvdnwp vnehyptgnt dnerfqmvkq kipfkynrpv eewlqekgrq ltifntqaqi
     1261 aiggkdkgrl fqgqlsglyy dglkvlnmaa ennpniking svrlvgevps ilgttqttsm
     1321 ppemsttvme ttttmatttt rknrstasiq ptsddlvssa ecssddedfv ecepstgrsd
     1381 kslstsifeg gykahapkwe skdfrpnkvs etsrttttsl spelirftas sssgmvpklp
     1441 agkmnnrdlk pqpdivllpl ptayeldstk lksplitspm frnvptanpt epgirrvpga
     1501 seviressst tgmvvgivaa aalcililly amykyrnrde gsyqvdetrn yisnsaqsng
     1561 tlmkekqqss ksghkkqknk dreyyv
//
LOCUS       XP_011535671            1583 aa            linear   PRI 05-AUG-2025
DEFINITION  neurexin 3 isoform X16 [Homo sapiens].
ACCESSION   XP_011535671
VERSION     XP_011535671.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537369.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1583
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1583
                     /product="neurexin 3 isoform X16"
                     /calculated_mol_wt=174749
     Region          35..181
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          202..232
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          286..425
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          482..631
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          659..692
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          720..854
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          911..1039
                     /region_name="Laminin_G_2"
                     /note="Laminin G domain; pfam02210"
                     /db_xref="CDD:460494"
     Region          1103..1282
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          1509..1565
                     /region_name="Syndecan"
                     /note="Syndecan domain; pfam01034"
                     /db_xref="CDD:460035"
     Region          1529..1547
                     /region_name="4.1m"
                     /note="putative band 4.1 homologues' binding motif;
                     smart00294"
                     /db_xref="CDD:128590"
     CDS             1..1583
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /coded_by="XM_011537369.2:1006..5757"
                     /db_xref="GeneID:9369"
                     /db_xref="HGNC:HGNC:8010"
                     /db_xref="MIM:600567"
ORIGIN      
        1 msstlhsvff tlkvsillgs llglclglef mglpnqwary lrwdastrsd lsfqfktnvs
       61 tglllylddg gvcdflclsl vdgrvqlrfs mdcaetavls nkqvndsswh flmvsrdrlr
      121 tvlmldgegq sgelqpqrpy mdvvsdlflg gvptdirpsa ltldgvqamp gfkglildlk
      181 ygnseprllg srgvqmdaeg pcgerpceng gicflldghp tcdcsttgyg gklcsedvsq
      241 dpglshlmms eqgrskaree nvatfrgsey lcydlsqnpi qsssdeitls fktwqrngli
      301 lhtgksadyv nlalkdgavs lvinlgsgaf eaivepvngk fndnawhdvk vtrnlrqhsg
      361 ighamvtisv dgiltttgyt qedytmlgsd dffyvggsps tadlpgspvs nnfmgclkev
      421 vyknndirle lsrlariadt kmkiygevvf kcenvatldp infetpeayi slpkwntkrm
      481 gsisfdfrtt epnglilfth gkpqerkdar sqkntkvdff avelldgnly llldmgsgti
      541 kvkatqkkan dgewyhvdiq rdgrsgtisv nsrrtpftas geseildleg dmylgglpen
      601 raglilptel wtamlnygyv gcirdlfidg rsknirqlae mqnaagvkss csrmsakqcd
      661 sypcknnavc kdgwnrficd ctgtgywgrt cereasilsy dgsmymkiim pmvmhteaed
      721 vsfrfmsqra ygllvattsr dsadtlrlel dggrvklmvn ldcirincns skgpetlyag
      781 qklndnewht vrvvrrgksl kltvdddvae gtmvgdhtrl efhnietgim tekryisvvp
      841 ssfighlqsl mfngllyidl ckngdidyce lkarfglrni iadpvtfktk ssylslatlq
      901 aytsmhlffq fkttspdgfi lfnsgdgndf iavelvkgyi hyvfdlgngp nvikgnsdrp
      961 lndnqwhnvv itrdnsnths lkvdtkvvtq vingaknldl kgdlymagla qgmysnlpkl
     1021 vasrdgfqgc lasvdlngrl pdlindalhr sgqiergceg psttcqedsc anqgvcmqqw
     1081 egftcdcsmt sysgnqcndp gatyifgksg glilytwpan drpstrsdrl avgfsttvkd
     1141 gilvridsap glgdflqlhi eqgkigvvfn igtvdisike ertpvndgky hvvrftrngg
     1201 natlqvdnwp vnehyptgnt dnerfqmvkq kipfkynrpv eewlqekgrq ltifntqaqi
     1261 aiggkdkgrl fqgqlsglyy dglkvlnmaa ennpniking svrlvgevps ilgttqttsm
     1321 ppemsttvme ttttmatttt rknrstasiq ptsddlvssa ecssddedfv ecepstdksl
     1381 stsifeggyk ahapkweskd frpnkvsets rttttslspe lirftassss gmvpklpagk
     1441 mnnrdlkpqp divllplpta yeldstklks plitspmfrn vptanptepg irrvpgasev
     1501 iresssttgm vvgivaaaal cilillyamy kyrnrdegsy qvdetrnyis nsaqsngtlm
     1561 kekqqssksg hkkqknkdre yyv
//
LOCUS       XP_047287901            1579 aa            linear   PRI 05-AUG-2025
DEFINITION  neurexin 3 isoform X17 [Homo sapiens].
ACCESSION   XP_047287901
VERSION     XP_047287901.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431945.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1579
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1579
                     /product="neurexin 3 isoform X17"
                     /calculated_mol_wt=174320
     Region          35..181
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          202..232
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          282..421
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          478..627
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          655..688
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          716..850
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          907..1035
                     /region_name="Laminin_G_2"
                     /note="Laminin G domain; pfam02210"
                     /db_xref="CDD:460494"
     Region          1099..1278
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          1505..1561
                     /region_name="Syndecan"
                     /note="Syndecan domain; pfam01034"
                     /db_xref="CDD:460035"
     Region          1525..1543
                     /region_name="4.1m"
                     /note="putative band 4.1 homologues' binding motif;
                     smart00294"
                     /db_xref="CDD:128590"
     CDS             1..1579
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /coded_by="XM_047431945.1:1006..5745"
                     /db_xref="GeneID:9369"
                     /db_xref="HGNC:HGNC:8010"
                     /db_xref="MIM:600567"
ORIGIN      
        1 msstlhsvff tlkvsillgs llglclglef mglpnqwary lrwdastrsd lsfqfktnvs
       61 tglllylddg gvcdflclsl vdgrvqlrfs mdcaetavls nkqvndsswh flmvsrdrlr
      121 tvlmldgegq sgelqpqrpy mdvvsdlflg gvptdirpsa ltldgvqamp gfkglildlk
      181 ygnseprllg srgvqmdaeg pcgerpceng gicflldghp tcdcsttgyg gklcsedvsq
      241 dpglshlmms eqareenvat frgseylcyd lsqnpiqsss deitlsfktw qrnglilhtg
      301 ksadyvnlal kdgavslvin lgsgafeaiv epvngkfndn awhdvkvtrn lrqhsgigha
      361 mvtisvdgil tttgytqedy tmlgsddffy vggspstadl pgspvsnnfm gclkevvykn
      421 ndirlelsrl ariadtkmki ygevvfkcen vatldpinfe tpeayislpk wntkrmgsis
      481 fdfrttepng lilfthgkpq erkdarsqkn tkvdffavel ldgnlyllld mgsgtikvka
      541 tqkkandgew yhvdiqrdgr sgtisvnsrr tpftasgese ildlegdmyl gglpenragl
      601 ilptelwtam lnygyvgcir dlfidgrskn irqlaemqna agvksscsrm sakqcdsypc
      661 knnavckdgw nrficdctgt gywgrtcere asilsydgsm ymkiimpmvm hteaedvsfr
      721 fmsqraygll vattsrdsad tlrleldggr vklmvnldci rincnsskgp etlyagqkln
      781 dnewhtvrvv rrgkslkltv dddvaegtmv gdhtrlefhn ietgimtekr yisvvpssfi
      841 ghlqslmfng llyidlckng didycelkar fglrniiadp vtfktkssyl slatlqayts
      901 mhlffqfktt spdgfilfns gdgndfiave lvkgyihyvf dlgngpnvik gnsdrplndn
      961 qwhnvvitrd nsnthslkvd tkvvtqving aknldlkgdl ymaglaqgmy snlpklvasr
     1021 dgfqgclasv dlngrlpdli ndalhrsgqi ergcegpstt cqedscanqg vcmqqwegft
     1081 cdcsmtsysg nqcndpgaty ifgksgglil ytwpandrps trsdrlavgf sttvkdgilv
     1141 ridsapglgd flqlhieqgk igvvfnigtv disikeertp vndgkyhvvr ftrnggnatl
     1201 qvdnwpvneh yptgntdner fqmvkqkipf kynrpveewl qekgrqltif ntqaqiaigg
     1261 kdkgrlfqgq lsglyydglk vlnmaaennp nikingsvrl vgevpsilgt tqttsmppem
     1321 sttvmetttt mattttrknr stasiqptsd dlvssaecss ddedfvecep stdkslstsi
     1381 feggykahap kweskdfrpn kvsetsrttt tslspelirf tassssgmvp klpagkmnnr
     1441 dlkpqpdivl lplptayeld stklksplit spmfrnvpta nptepgirrv pgasevires
     1501 ssttgmvvgi vaaaalcili llyamykyrn rdegsyqvde trnyisnsaq sngtlmkekq
     1561 qssksghkkq knkdreyyv
//
LOCUS       XP_047287902            1578 aa            linear   PRI 05-AUG-2025
DEFINITION  neurexin 3 isoform X18 [Homo sapiens].
ACCESSION   XP_047287902
VERSION     XP_047287902.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431946.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1578
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1578
                     /product="neurexin 3 isoform X18"
                     /calculated_mol_wt=174258
     Region          35..181
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          202..232
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          286..417
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          474..623
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          651..684
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          712..846
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          903..1031
                     /region_name="Laminin_G_2"
                     /note="Laminin G domain; pfam02210"
                     /db_xref="CDD:460494"
     Region          1095..1274
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          1504..1560
                     /region_name="Syndecan"
                     /note="Syndecan domain; pfam01034"
                     /db_xref="CDD:460035"
     Region          1524..1542
                     /region_name="4.1m"
                     /note="putative band 4.1 homologues' binding motif;
                     smart00294"
                     /db_xref="CDD:128590"
     CDS             1..1578
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /coded_by="XM_047431946.1:1006..5742"
                     /db_xref="GeneID:9369"
                     /db_xref="HGNC:HGNC:8010"
                     /db_xref="MIM:600567"
ORIGIN      
        1 msstlhsvff tlkvsillgs llglclglef mglpnqwary lrwdastrsd lsfqfktnvs
       61 tglllylddg gvcdflclsl vdgrvqlrfs mdcaetavls nkqvndsswh flmvsrdrlr
      121 tvlmldgegq sgelqpqrpy mdvvsdlflg gvptdirpsa ltldgvqamp gfkglildlk
      181 ygnseprllg srgvqmdaeg pcgerpceng gicflldghp tcdcsttgyg gklcsedvsq
      241 dpglshlmms eqgrskaree nvatfrgsey lcydlsqnpi qsssdeitls fktwqrngli
      301 lhtgksadyv nlalkdgavs lvinlgsgaf eaivepvngk fndnawhdvk vtrnlrqvti
      361 svdgiltttg ytqedytmlg sddffyvggs pstadlpgsp vsnnfmgclk evvyknndir
      421 lelsrlaria dtkmkiygev vfkcenvatl dpinfetpea yislpkwntk rmgsisfdfr
      481 ttepnglilf thgkpqerkd arsqkntkvd ffavelldgn lyllldmgsg tikvkatqkk
      541 andgewyhvd iqrdgrsgti svnsrrtpft asgeseildl egdmylgglp enraglilpt
      601 elwtamlnyg yvgcirdlfi dgrsknirql aemqnaagvk sscsrmsakq cdsypcknna
      661 vckdgwnrfi cdctgtgywg rtcereasil sydgsmymki impmvmhtea edvsfrfmsq
      721 raygllvatt srdsadtlrl eldggrvklm vnldcirinc nsskgpetly agqklndnew
      781 htvrvvrrgk slkltvdddv aegtmvgdht rlefhnietg imtekryisv vpssfighlq
      841 slmfngllyi dlckngdidy celkarfglr niiadpvtfk tkssylslat lqaytsmhlf
      901 fqfkttspdg filfnsgdgn dfiavelvkg yihyvfdlgn gpnvikgnsd rplndnqwhn
      961 vvitrdnsnt hslkvdtkvv tqvingaknl dlkgdlymag laqgmysnlp klvasrdgfq
     1021 gclasvdlng rlpdlindal hrsgqiergc egpsttcqed scanqgvcmq qwegftcdcs
     1081 mtsysgnqcn dpgatyifgk sgglilytwp andrpstrsd rlavgfsttv kdgilvrids
     1141 apglgdflql hieqgkigvv fnigtvdisi keertpvndg kyhvvrftrn ggnatlqvdn
     1201 wpvnehyptg ntdnerfqmv kqkipfkynr pveewlqekg rqltifntqa qiaiggkdkg
     1261 rlfqgqlsgl yydglkvlnm aaennpniki ngsvrlvgev psilgttqtt smppemsttv
     1321 mettttmatt ttrknrstas iqptsddlvs saecssdded fvecepstgr sdkslstsif
     1381 eggykahapk weskdfrpnk vsetsrtttt slspelirft assssgmvpk lpagkmnnrd
     1441 lkpqpdivll plptayelds tklksplits pmfrnvptan ptepgirrvp gaseviress
     1501 sttgmvvgiv aaaalcilil lyamykyrnr degsyqvdet rnyisnsaqs ngtlmkekqq
     1561 ssksghkkqk nkdreyyv
//
LOCUS       XP_011535672            1575 aa            linear   PRI 05-AUG-2025
DEFINITION  neurexin 3 isoform X19 [Homo sapiens].
ACCESSION   XP_011535672
VERSION     XP_011535672.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537370.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1575
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1575
                     /product="neurexin 3 isoform X19"
                     /calculated_mol_wt=173958
     Region          35..181
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          202..232
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          286..417
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          474..623
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          651..684
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          712..846
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          903..1031
                     /region_name="Laminin_G_2"
                     /note="Laminin G domain; pfam02210"
                     /db_xref="CDD:460494"
     Region          1095..1274
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          1501..1557
                     /region_name="Syndecan"
                     /note="Syndecan domain; pfam01034"
                     /db_xref="CDD:460035"
     Region          1521..1539
                     /region_name="4.1m"
                     /note="putative band 4.1 homologues' binding motif;
                     smart00294"
                     /db_xref="CDD:128590"
     CDS             1..1575
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /coded_by="XM_011537370.2:1006..5733"
                     /db_xref="GeneID:9369"
                     /db_xref="HGNC:HGNC:8010"
                     /db_xref="MIM:600567"
ORIGIN      
        1 msstlhsvff tlkvsillgs llglclglef mglpnqwary lrwdastrsd lsfqfktnvs
       61 tglllylddg gvcdflclsl vdgrvqlrfs mdcaetavls nkqvndsswh flmvsrdrlr
      121 tvlmldgegq sgelqpqrpy mdvvsdlflg gvptdirpsa ltldgvqamp gfkglildlk
      181 ygnseprllg srgvqmdaeg pcgerpceng gicflldghp tcdcsttgyg gklcsedvsq
      241 dpglshlmms eqgrskaree nvatfrgsey lcydlsqnpi qsssdeitls fktwqrngli
      301 lhtgksadyv nlalkdgavs lvinlgsgaf eaivepvngk fndnawhdvk vtrnlrqvti
      361 svdgiltttg ytqedytmlg sddffyvggs pstadlpgsp vsnnfmgclk evvyknndir
      421 lelsrlaria dtkmkiygev vfkcenvatl dpinfetpea yislpkwntk rmgsisfdfr
      481 ttepnglilf thgkpqerkd arsqkntkvd ffavelldgn lyllldmgsg tikvkatqkk
      541 andgewyhvd iqrdgrsgti svnsrrtpft asgeseildl egdmylgglp enraglilpt
      601 elwtamlnyg yvgcirdlfi dgrsknirql aemqnaagvk sscsrmsakq cdsypcknna
      661 vckdgwnrfi cdctgtgywg rtcereasil sydgsmymki impmvmhtea edvsfrfmsq
      721 raygllvatt srdsadtlrl eldggrvklm vnldcirinc nsskgpetly agqklndnew
      781 htvrvvrrgk slkltvdddv aegtmvgdht rlefhnietg imtekryisv vpssfighlq
      841 slmfngllyi dlckngdidy celkarfglr niiadpvtfk tkssylslat lqaytsmhlf
      901 fqfkttspdg filfnsgdgn dfiavelvkg yihyvfdlgn gpnvikgnsd rplndnqwhn
      961 vvitrdnsnt hslkvdtkvv tqvingaknl dlkgdlymag laqgmysnlp klvasrdgfq
     1021 gclasvdlng rlpdlindal hrsgqiergc egpsttcqed scanqgvcmq qwegftcdcs
     1081 mtsysgnqcn dpgatyifgk sgglilytwp andrpstrsd rlavgfsttv kdgilvrids
     1141 apglgdflql hieqgkigvv fnigtvdisi keertpvndg kyhvvrftrn ggnatlqvdn
     1201 wpvnehyptg ntdnerfqmv kqkipfkynr pveewlqekg rqltifntqa qiaiggkdkg
     1261 rlfqgqlsgl yydglkvlnm aaennpniki ngsvrlvgev psilgttqtt smppemsttv
     1321 mettttmatt ttrknrstas iqptsddlvs saecssdded fvecepstdk slstsifegg
     1381 ykahapkwes kdfrpnkvse tsrttttsls pelirftass ssgmvpklpa gkmnnrdlkp
     1441 qpdivllplp tayeldstkl ksplitspmf rnvptanpte pgirrvpgas eviressstt
     1501 gmvvgivaaa alcilillya mykyrnrdeg syqvdetrny isnsaqsngt lmkekqqssk
     1561 sghkkqknkd reyyv
//
LOCUS       XP_047287903            1574 aa            linear   PRI 05-AUG-2025
DEFINITION  neurexin 3 isoform X20 [Homo sapiens].
ACCESSION   XP_047287903
VERSION     XP_047287903.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431947.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1574
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1574
                     /product="neurexin 3 isoform X20"
                     /calculated_mol_wt=173830
     Region          35..181
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          202..232
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          282..413
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          470..619
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          647..680
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          708..842
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          899..1027
                     /region_name="Laminin_G_2"
                     /note="Laminin G domain; pfam02210"
                     /db_xref="CDD:460494"
     Region          1091..1270
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          1500..1556
                     /region_name="Syndecan"
                     /note="Syndecan domain; pfam01034"
                     /db_xref="CDD:460035"
     Region          1520..1538
                     /region_name="4.1m"
                     /note="putative band 4.1 homologues' binding motif;
                     smart00294"
                     /db_xref="CDD:128590"
     CDS             1..1574
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /coded_by="XM_047431947.1:1006..5730"
                     /db_xref="GeneID:9369"
                     /db_xref="HGNC:HGNC:8010"
                     /db_xref="MIM:600567"
ORIGIN      
        1 msstlhsvff tlkvsillgs llglclglef mglpnqwary lrwdastrsd lsfqfktnvs
       61 tglllylddg gvcdflclsl vdgrvqlrfs mdcaetavls nkqvndsswh flmvsrdrlr
      121 tvlmldgegq sgelqpqrpy mdvvsdlflg gvptdirpsa ltldgvqamp gfkglildlk
      181 ygnseprllg srgvqmdaeg pcgerpceng gicflldghp tcdcsttgyg gklcsedvsq
      241 dpglshlmms eqareenvat frgseylcyd lsqnpiqsss deitlsfktw qrnglilhtg
      301 ksadyvnlal kdgavslvin lgsgafeaiv epvngkfndn awhdvkvtrn lrqvtisvdg
      361 iltttgytqe dytmlgsddf fyvggspsta dlpgspvsnn fmgclkevvy knndirlels
      421 rlariadtkm kiygevvfkc envatldpin fetpeayisl pkwntkrmgs isfdfrttep
      481 nglilfthgk pqerkdarsq kntkvdffav elldgnlyll ldmgsgtikv katqkkandg
      541 ewyhvdiqrd grsgtisvns rrtpftasge seildlegdm ylgglpenra glilptelwt
      601 amlnygyvgc irdlfidgrs knirqlaemq naagvksscs rmsakqcdsy pcknnavckd
      661 gwnrficdct gtgywgrtce reasilsydg smymkiimpm vmhteaedvs frfmsqrayg
      721 llvattsrds adtlrleldg grvklmvnld cirincnssk gpetlyagqk lndnewhtvr
      781 vvrrgkslkl tvdddvaegt mvgdhtrlef hnietgimte kryisvvpss fighlqslmf
      841 ngllyidlck ngdidycelk arfglrniia dpvtfktkss ylslatlqay tsmhlffqfk
      901 ttspdgfilf nsgdgndfia velvkgyihy vfdlgngpnv ikgnsdrpln dnqwhnvvit
      961 rdnsnthslk vdtkvvtqvi ngaknldlkg dlymaglaqg mysnlpklva srdgfqgcla
     1021 svdlngrlpd lindalhrsg qiergcegps ttcqedscan qgvcmqqweg ftcdcsmtsy
     1081 sgnqcndpga tyifgksggl ilytwpandr pstrsdrlav gfsttvkdgi lvridsapgl
     1141 gdflqlhieq gkigvvfnig tvdisikeer tpvndgkyhv vrftrnggna tlqvdnwpvn
     1201 ehyptgntdn erfqmvkqki pfkynrpvee wlqekgrqlt ifntqaqiai ggkdkgrlfq
     1261 gqlsglyydg lkvlnmaaen npnikingsv rlvgevpsil gttqttsmpp emsttvmett
     1321 ttmattttrk nrstasiqpt sddlvssaec ssddedfvec epstgrsdks lstsifeggy
     1381 kahapkwesk dfrpnkvset srttttslsp elirftasss sgmvpklpag kmnnrdlkpq
     1441 pdivllplpt ayeldstklk splitspmfr nvptanptep girrvpgase viresssttg
     1501 mvvgivaaaa lcilillyam ykyrnrdegs yqvdetrnyi snsaqsngtl mkekqqssks
     1561 ghkkqknkdr eyyv
//
LOCUS       XP_047287904            1565 aa            linear   PRI 05-AUG-2025
DEFINITION  neurexin 3 isoform X21 [Homo sapiens].
ACCESSION   XP_047287904
VERSION     XP_047287904.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431948.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1565
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1565
                     /product="neurexin 3 isoform X21"
                     /calculated_mol_wt=172781
     Region          35..181
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          202..232
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          282..413
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          470..619
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          647..680
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          708..833
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          890..1018
                     /region_name="Laminin_G_2"
                     /note="Laminin G domain; pfam02210"
                     /db_xref="CDD:460494"
     Region          1082..1261
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          1491..1547
                     /region_name="Syndecan"
                     /note="Syndecan domain; pfam01034"
                     /db_xref="CDD:460035"
     Region          1511..1529
                     /region_name="4.1m"
                     /note="putative band 4.1 homologues' binding motif;
                     smart00294"
                     /db_xref="CDD:128590"
     CDS             1..1565
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /coded_by="XM_047431948.1:1006..5703"
                     /db_xref="GeneID:9369"
                     /db_xref="HGNC:HGNC:8010"
                     /db_xref="MIM:600567"
ORIGIN      
        1 msstlhsvff tlkvsillgs llglclglef mglpnqwary lrwdastrsd lsfqfktnvs
       61 tglllylddg gvcdflclsl vdgrvqlrfs mdcaetavls nkqvndsswh flmvsrdrlr
      121 tvlmldgegq sgelqpqrpy mdvvsdlflg gvptdirpsa ltldgvqamp gfkglildlk
      181 ygnseprllg srgvqmdaeg pcgerpceng gicflldghp tcdcsttgyg gklcsedvsq
      241 dpglshlmms eqareenvat frgseylcyd lsqnpiqsss deitlsfktw qrnglilhtg
      301 ksadyvnlal kdgavslvin lgsgafeaiv epvngkfndn awhdvkvtrn lrqvtisvdg
      361 iltttgytqe dytmlgsddf fyvggspsta dlpgspvsnn fmgclkevvy knndirlels
      421 rlariadtkm kiygevvfkc envatldpin fetpeayisl pkwntkrmgs isfdfrttep
      481 nglilfthgk pqerkdarsq kntkvdffav elldgnlyll ldmgsgtikv katqkkandg
      541 ewyhvdiqrd grsgtisvns rrtpftasge seildlegdm ylgglpenra glilptelwt
      601 amlnygyvgc irdlfidgrs knirqlaemq naagvksscs rmsakqcdsy pcknnavckd
      661 gwnrficdct gtgywgrtce reasilsydg smymkiimpm vmhteaedvs frfmsqrayg
      721 llvattsrds adtlrleldg grvklmvnlg kgpetlyagq klndnewhtv rvvrrgkslk
      781 ltvdddvaeg tmvgdhtrle fhnietgimt ekryisvvps sfighlqslm fngllyidlc
      841 kngdidycel karfglrnii adpvtfktks sylslatlqa ytsmhlffqf kttspdgfil
      901 fnsgdgndfi avelvkgyih yvfdlgngpn vikgnsdrpl ndnqwhnvvi trdnsnthsl
      961 kvdtkvvtqv ingaknldlk gdlymaglaq gmysnlpklv asrdgfqgcl asvdlngrlp
     1021 dlindalhrs gqiergcegp sttcqedsca nqgvcmqqwe gftcdcsmts ysgnqcndpg
     1081 atyifgksgg lilytwpand rpstrsdrla vgfsttvkdg ilvridsapg lgdflqlhie
     1141 qgkigvvfni gtvdisikee rtpvndgkyh vvrftrnggn atlqvdnwpv nehyptgntd
     1201 nerfqmvkqk ipfkynrpve ewlqekgrql tifntqaqia iggkdkgrlf qgqlsglyyd
     1261 glkvlnmaae nnpnikings vrlvgevpsi lgttqttsmp pemsttvmet tttmattttr
     1321 knrstasiqp tsddlvssae cssddedfve cepstgrsdk slstsifegg ykahapkwes
     1381 kdfrpnkvse tsrttttsls pelirftass ssgmvpklpa gkmnnrdlkp qpdivllplp
     1441 tayeldstkl ksplitspmf rnvptanpte pgirrvpgas eviressstt gmvvgivaaa
     1501 alcilillya mykyrnrdeg syqvdetrny isnsaqsngt lmkekqqssk sghkkqknkd
     1561 reyyv
//
LOCUS       XP_047287905            1562 aa            linear   PRI 05-AUG-2025
DEFINITION  neurexin 3 isoform X22 [Homo sapiens].
ACCESSION   XP_047287905
VERSION     XP_047287905.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431949.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1562
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1562
                     /product="neurexin 3 isoform X22"
                     /calculated_mol_wt=172480
     Region          35..181
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          202..232
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          282..413
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          470..619
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          647..680
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          708..833
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          890..1018
                     /region_name="Laminin_G_2"
                     /note="Laminin G domain; pfam02210"
                     /db_xref="CDD:460494"
     Region          1082..1261
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          1488..1544
                     /region_name="Syndecan"
                     /note="Syndecan domain; pfam01034"
                     /db_xref="CDD:460035"
     Region          1508..1526
                     /region_name="4.1m"
                     /note="putative band 4.1 homologues' binding motif;
                     smart00294"
                     /db_xref="CDD:128590"
     CDS             1..1562
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /coded_by="XM_047431949.1:1006..5694"
                     /db_xref="GeneID:9369"
                     /db_xref="HGNC:HGNC:8010"
                     /db_xref="MIM:600567"
ORIGIN      
        1 msstlhsvff tlkvsillgs llglclglef mglpnqwary lrwdastrsd lsfqfktnvs
       61 tglllylddg gvcdflclsl vdgrvqlrfs mdcaetavls nkqvndsswh flmvsrdrlr
      121 tvlmldgegq sgelqpqrpy mdvvsdlflg gvptdirpsa ltldgvqamp gfkglildlk
      181 ygnseprllg srgvqmdaeg pcgerpceng gicflldghp tcdcsttgyg gklcsedvsq
      241 dpglshlmms eqareenvat frgseylcyd lsqnpiqsss deitlsfktw qrnglilhtg
      301 ksadyvnlal kdgavslvin lgsgafeaiv epvngkfndn awhdvkvtrn lrqvtisvdg
      361 iltttgytqe dytmlgsddf fyvggspsta dlpgspvsnn fmgclkevvy knndirlels
      421 rlariadtkm kiygevvfkc envatldpin fetpeayisl pkwntkrmgs isfdfrttep
      481 nglilfthgk pqerkdarsq kntkvdffav elldgnlyll ldmgsgtikv katqkkandg
      541 ewyhvdiqrd grsgtisvns rrtpftasge seildlegdm ylgglpenra glilptelwt
      601 amlnygyvgc irdlfidgrs knirqlaemq naagvksscs rmsakqcdsy pcknnavckd
      661 gwnrficdct gtgywgrtce reasilsydg smymkiimpm vmhteaedvs frfmsqrayg
      721 llvattsrds adtlrleldg grvklmvnlg kgpetlyagq klndnewhtv rvvrrgkslk
      781 ltvdddvaeg tmvgdhtrle fhnietgimt ekryisvvps sfighlqslm fngllyidlc
      841 kngdidycel karfglrnii adpvtfktks sylslatlqa ytsmhlffqf kttspdgfil
      901 fnsgdgndfi avelvkgyih yvfdlgngpn vikgnsdrpl ndnqwhnvvi trdnsnthsl
      961 kvdtkvvtqv ingaknldlk gdlymaglaq gmysnlpklv asrdgfqgcl asvdlngrlp
     1021 dlindalhrs gqiergcegp sttcqedsca nqgvcmqqwe gftcdcsmts ysgnqcndpg
     1081 atyifgksgg lilytwpand rpstrsdrla vgfsttvkdg ilvridsapg lgdflqlhie
     1141 qgkigvvfni gtvdisikee rtpvndgkyh vvrftrnggn atlqvdnwpv nehyptgntd
     1201 nerfqmvkqk ipfkynrpve ewlqekgrql tifntqaqia iggkdkgrlf qgqlsglyyd
     1261 glkvlnmaae nnpnikings vrlvgevpsi lgttqttsmp pemsttvmet tttmattttr
     1321 knrstasiqp tsddlvssae cssddedfve cepstdksls tsifeggyka hapkweskdf
     1381 rpnkvsetsr ttttslspel irftassssg mvpklpagkm nnrdlkpqpd ivllplptay
     1441 eldstklksp litspmfrnv ptanptepgi rrvpgasevi resssttgmv vgivaaaalc
     1501 ilillyamyk yrnrdegsyq vdetrnyisn saqsngtlmk ekqqssksgh kkqknkdrey
     1561 yv
//
LOCUS       XP_016877289            1553 aa            linear   PRI 05-AUG-2025
DEFINITION  neurexin 3 isoform X23 [Homo sapiens].
ACCESSION   XP_016877289
VERSION     XP_016877289.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021800.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1553
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1553
                     /product="neurexin 3 isoform X23"
                     /calculated_mol_wt=171014
     Region          35..181
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          202..232
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          286..425
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          482..631
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          659..692
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          720..854
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          911..1039
                     /region_name="Laminin_G_2"
                     /note="Laminin G domain; pfam02210"
                     /db_xref="CDD:460494"
     Region          1103..1252
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          1479..1535
                     /region_name="Syndecan"
                     /note="Syndecan domain; pfam01034"
                     /db_xref="CDD:460035"
     Region          1499..1517
                     /region_name="4.1m"
                     /note="putative band 4.1 homologues' binding motif;
                     smart00294"
                     /db_xref="CDD:128590"
     CDS             1..1553
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /coded_by="XM_017021800.2:1006..5667"
                     /db_xref="GeneID:9369"
                     /db_xref="HGNC:HGNC:8010"
                     /db_xref="MIM:600567"
ORIGIN      
        1 msstlhsvff tlkvsillgs llglclglef mglpnqwary lrwdastrsd lsfqfktnvs
       61 tglllylddg gvcdflclsl vdgrvqlrfs mdcaetavls nkqvndsswh flmvsrdrlr
      121 tvlmldgegq sgelqpqrpy mdvvsdlflg gvptdirpsa ltldgvqamp gfkglildlk
      181 ygnseprllg srgvqmdaeg pcgerpceng gicflldghp tcdcsttgyg gklcsedvsq
      241 dpglshlmms eqgrskaree nvatfrgsey lcydlsqnpi qsssdeitls fktwqrngli
      301 lhtgksadyv nlalkdgavs lvinlgsgaf eaivepvngk fndnawhdvk vtrnlrqhsg
      361 ighamvtisv dgiltttgyt qedytmlgsd dffyvggsps tadlpgspvs nnfmgclkev
      421 vyknndirle lsrlariadt kmkiygevvf kcenvatldp infetpeayi slpkwntkrm
      481 gsisfdfrtt epnglilfth gkpqerkdar sqkntkvdff avelldgnly llldmgsgti
      541 kvkatqkkan dgewyhvdiq rdgrsgtisv nsrrtpftas geseildleg dmylgglpen
      601 raglilptel wtamlnygyv gcirdlfidg rsknirqlae mqnaagvkss csrmsakqcd
      661 sypcknnavc kdgwnrficd ctgtgywgrt cereasilsy dgsmymkiim pmvmhteaed
      721 vsfrfmsqra ygllvattsr dsadtlrlel dggrvklmvn ldcirincns skgpetlyag
      781 qklndnewht vrvvrrgksl kltvdddvae gtmvgdhtrl efhnietgim tekryisvvp
      841 ssfighlqsl mfngllyidl ckngdidyce lkarfglrni iadpvtfktk ssylslatlq
      901 aytsmhlffq fkttspdgfi lfnsgdgndf iavelvkgyi hyvfdlgngp nvikgnsdrp
      961 lndnqwhnvv itrdnsnths lkvdtkvvtq vingaknldl kgdlymagla qgmysnlpkl
     1021 vasrdgfqgc lasvdlngrl pdlindalhr sgqiergceg psttcqedsc anqgvcmqqw
     1081 egftcdcsmt sysgnqcndp gatyifgksg glilytwpan drpstrsdrl avgfsttvkd
     1141 gilvridsap glgdflqlhi eqgkigvvfn igtvdisike ertpvndgky hvvrftrngg
     1201 natlqvdnwp vnehyptgrq ltifntqaqi aiggkdkgrl fqgqlsglyy dglkvlnmaa
     1261 ennpniking svrlvgevps ilgttqttsm ppemsttvme ttttmatttt rknrstasiq
     1321 ptsddlvssa ecssddedfv ecepstdksl stsifeggyk ahapkweskd frpnkvsets
     1381 rttttslspe lirftassss gmvpklpagk mnnrdlkpqp divllplpta yeldstklks
     1441 plitspmfrn vptanptepg irrvpgasev iresssttgm vvgivaaaal cilillyamy
     1501 kyrnrdegsy qvdetrnyis nsaqsngtlm kekqqssksg hkkqknkdre yyv
//
LOCUS       XP_047287906            1552 aa            linear   PRI 05-AUG-2025
DEFINITION  neurexin 3 isoform X24 [Homo sapiens].
ACCESSION   XP_047287906
VERSION     XP_047287906.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431950.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1552
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1552
                     /product="neurexin 3 isoform X24"
                     /calculated_mol_wt=170885
     Region          35..181
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          202..232
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          282..421
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          478..627
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          655..688
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          716..850
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          907..1035
                     /region_name="Laminin_G_2"
                     /note="Laminin G domain; pfam02210"
                     /db_xref="CDD:460494"
     Region          1099..1248
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          1478..1534
                     /region_name="Syndecan"
                     /note="Syndecan domain; pfam01034"
                     /db_xref="CDD:460035"
     Region          1498..1516
                     /region_name="4.1m"
                     /note="putative band 4.1 homologues' binding motif;
                     smart00294"
                     /db_xref="CDD:128590"
     CDS             1..1552
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /coded_by="XM_047431950.1:1006..5664"
                     /db_xref="GeneID:9369"
                     /db_xref="HGNC:HGNC:8010"
                     /db_xref="MIM:600567"
ORIGIN      
        1 msstlhsvff tlkvsillgs llglclglef mglpnqwary lrwdastrsd lsfqfktnvs
       61 tglllylddg gvcdflclsl vdgrvqlrfs mdcaetavls nkqvndsswh flmvsrdrlr
      121 tvlmldgegq sgelqpqrpy mdvvsdlflg gvptdirpsa ltldgvqamp gfkglildlk
      181 ygnseprllg srgvqmdaeg pcgerpceng gicflldghp tcdcsttgyg gklcsedvsq
      241 dpglshlmms eqareenvat frgseylcyd lsqnpiqsss deitlsfktw qrnglilhtg
      301 ksadyvnlal kdgavslvin lgsgafeaiv epvngkfndn awhdvkvtrn lrqhsgigha
      361 mvtisvdgil tttgytqedy tmlgsddffy vggspstadl pgspvsnnfm gclkevvykn
      421 ndirlelsrl ariadtkmki ygevvfkcen vatldpinfe tpeayislpk wntkrmgsis
      481 fdfrttepng lilfthgkpq erkdarsqkn tkvdffavel ldgnlyllld mgsgtikvka
      541 tqkkandgew yhvdiqrdgr sgtisvnsrr tpftasgese ildlegdmyl gglpenragl
      601 ilptelwtam lnygyvgcir dlfidgrskn irqlaemqna agvksscsrm sakqcdsypc
      661 knnavckdgw nrficdctgt gywgrtcere asilsydgsm ymkiimpmvm hteaedvsfr
      721 fmsqraygll vattsrdsad tlrleldggr vklmvnldci rincnsskgp etlyagqkln
      781 dnewhtvrvv rrgkslkltv dddvaegtmv gdhtrlefhn ietgimtekr yisvvpssfi
      841 ghlqslmfng llyidlckng didycelkar fglrniiadp vtfktkssyl slatlqayts
      901 mhlffqfktt spdgfilfns gdgndfiave lvkgyihyvf dlgngpnvik gnsdrplndn
      961 qwhnvvitrd nsnthslkvd tkvvtqving aknldlkgdl ymaglaqgmy snlpklvasr
     1021 dgfqgclasv dlngrlpdli ndalhrsgqi ergcegpstt cqedscanqg vcmqqwegft
     1081 cdcsmtsysg nqcndpgaty ifgksgglil ytwpandrps trsdrlavgf sttvkdgilv
     1141 ridsapglgd flqlhieqgk igvvfnigtv disikeertp vndgkyhvvr ftrnggnatl
     1201 qvdnwpvneh yptgrqltif ntqaqiaigg kdkgrlfqgq lsglyydglk vlnmaaennp
     1261 nikingsvrl vgevpsilgt tqttsmppem sttvmetttt mattttrknr stasiqptsd
     1321 dlvssaecss ddedfvecep stgrsdksls tsifeggyka hapkweskdf rpnkvsetsr
     1381 ttttslspel irftassssg mvpklpagkm nnrdlkpqpd ivllplptay eldstklksp
     1441 litspmfrnv ptanptepgi rrvpgasevi resssttgmv vgivaaaalc ilillyamyk
     1501 yrnrdegsyq vdetrnyisn saqsngtlmk ekqqssksgh kkqknkdrey yv
//
LOCUS       XP_047287907            1549 aa            linear   PRI 05-AUG-2025
DEFINITION  neurexin 3 isoform X25 [Homo sapiens].
ACCESSION   XP_047287907
VERSION     XP_047287907.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431951.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1549
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1549
                     /product="neurexin 3 isoform X25"
                     /calculated_mol_wt=170585
     Region          35..181
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          202..232
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          282..421
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          478..627
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          655..688
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          716..850
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          907..1035
                     /region_name="Laminin_G_2"
                     /note="Laminin G domain; pfam02210"
                     /db_xref="CDD:460494"
     Region          1099..1248
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          1475..1531
                     /region_name="Syndecan"
                     /note="Syndecan domain; pfam01034"
                     /db_xref="CDD:460035"
     Region          1495..1513
                     /region_name="4.1m"
                     /note="putative band 4.1 homologues' binding motif;
                     smart00294"
                     /db_xref="CDD:128590"
     CDS             1..1549
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /coded_by="XM_047431951.1:1006..5655"
                     /db_xref="GeneID:9369"
                     /db_xref="HGNC:HGNC:8010"
                     /db_xref="MIM:600567"
ORIGIN      
        1 msstlhsvff tlkvsillgs llglclglef mglpnqwary lrwdastrsd lsfqfktnvs
       61 tglllylddg gvcdflclsl vdgrvqlrfs mdcaetavls nkqvndsswh flmvsrdrlr
      121 tvlmldgegq sgelqpqrpy mdvvsdlflg gvptdirpsa ltldgvqamp gfkglildlk
      181 ygnseprllg srgvqmdaeg pcgerpceng gicflldghp tcdcsttgyg gklcsedvsq
      241 dpglshlmms eqareenvat frgseylcyd lsqnpiqsss deitlsfktw qrnglilhtg
      301 ksadyvnlal kdgavslvin lgsgafeaiv epvngkfndn awhdvkvtrn lrqhsgigha
      361 mvtisvdgil tttgytqedy tmlgsddffy vggspstadl pgspvsnnfm gclkevvykn
      421 ndirlelsrl ariadtkmki ygevvfkcen vatldpinfe tpeayislpk wntkrmgsis
      481 fdfrttepng lilfthgkpq erkdarsqkn tkvdffavel ldgnlyllld mgsgtikvka
      541 tqkkandgew yhvdiqrdgr sgtisvnsrr tpftasgese ildlegdmyl gglpenragl
      601 ilptelwtam lnygyvgcir dlfidgrskn irqlaemqna agvksscsrm sakqcdsypc
      661 knnavckdgw nrficdctgt gywgrtcere asilsydgsm ymkiimpmvm hteaedvsfr
      721 fmsqraygll vattsrdsad tlrleldggr vklmvnldci rincnsskgp etlyagqkln
      781 dnewhtvrvv rrgkslkltv dddvaegtmv gdhtrlefhn ietgimtekr yisvvpssfi
      841 ghlqslmfng llyidlckng didycelkar fglrniiadp vtfktkssyl slatlqayts
      901 mhlffqfktt spdgfilfns gdgndfiave lvkgyihyvf dlgngpnvik gnsdrplndn
      961 qwhnvvitrd nsnthslkvd tkvvtqving aknldlkgdl ymaglaqgmy snlpklvasr
     1021 dgfqgclasv dlngrlpdli ndalhrsgqi ergcegpstt cqedscanqg vcmqqwegft
     1081 cdcsmtsysg nqcndpgaty ifgksgglil ytwpandrps trsdrlavgf sttvkdgilv
     1141 ridsapglgd flqlhieqgk igvvfnigtv disikeertp vndgkyhvvr ftrnggnatl
     1201 qvdnwpvneh yptgrqltif ntqaqiaigg kdkgrlfqgq lsglyydglk vlnmaaennp
     1261 nikingsvrl vgevpsilgt tqttsmppem sttvmetttt mattttrknr stasiqptsd
     1321 dlvssaecss ddedfvecep stdkslstsi feggykahap kweskdfrpn kvsetsrttt
     1381 tslspelirf tassssgmvp klpagkmnnr dlkpqpdivl lplptayeld stklksplit
     1441 spmfrnvpta nptepgirrv pgasevires ssttgmvvgi vaaaalcili llyamykyrn
     1501 rdegsyqvde trnyisnsaq sngtlmkekq qssksghkkq knkdreyyv
//
LOCUS       XP_047287908            1544 aa            linear   PRI 05-AUG-2025
DEFINITION  neurexin 3 isoform X26 [Homo sapiens].
ACCESSION   XP_047287908
VERSION     XP_047287908.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431952.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1544
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1544
                     /product="neurexin 3 isoform X26"
                     /calculated_mol_wt=170094
     Region          35..181
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          202..232
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          282..413
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          470..619
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          647..680
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          708..842
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          899..1027
                     /region_name="Laminin_G_2"
                     /note="Laminin G domain; pfam02210"
                     /db_xref="CDD:460494"
     Region          1091..1240
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          1470..1526
                     /region_name="Syndecan"
                     /note="Syndecan domain; pfam01034"
                     /db_xref="CDD:460035"
     Region          1490..1508
                     /region_name="4.1m"
                     /note="putative band 4.1 homologues' binding motif;
                     smart00294"
                     /db_xref="CDD:128590"
     CDS             1..1544
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /coded_by="XM_047431952.1:1006..5640"
                     /db_xref="GeneID:9369"
                     /db_xref="HGNC:HGNC:8010"
                     /db_xref="MIM:600567"
ORIGIN      
        1 msstlhsvff tlkvsillgs llglclglef mglpnqwary lrwdastrsd lsfqfktnvs
       61 tglllylddg gvcdflclsl vdgrvqlrfs mdcaetavls nkqvndsswh flmvsrdrlr
      121 tvlmldgegq sgelqpqrpy mdvvsdlflg gvptdirpsa ltldgvqamp gfkglildlk
      181 ygnseprllg srgvqmdaeg pcgerpceng gicflldghp tcdcsttgyg gklcsedvsq
      241 dpglshlmms eqareenvat frgseylcyd lsqnpiqsss deitlsfktw qrnglilhtg
      301 ksadyvnlal kdgavslvin lgsgafeaiv epvngkfndn awhdvkvtrn lrqvtisvdg
      361 iltttgytqe dytmlgsddf fyvggspsta dlpgspvsnn fmgclkevvy knndirlels
      421 rlariadtkm kiygevvfkc envatldpin fetpeayisl pkwntkrmgs isfdfrttep
      481 nglilfthgk pqerkdarsq kntkvdffav elldgnlyll ldmgsgtikv katqkkandg
      541 ewyhvdiqrd grsgtisvns rrtpftasge seildlegdm ylgglpenra glilptelwt
      601 amlnygyvgc irdlfidgrs knirqlaemq naagvksscs rmsakqcdsy pcknnavckd
      661 gwnrficdct gtgywgrtce reasilsydg smymkiimpm vmhteaedvs frfmsqrayg
      721 llvattsrds adtlrleldg grvklmvnld cirincnssk gpetlyagqk lndnewhtvr
      781 vvrrgkslkl tvdddvaegt mvgdhtrlef hnietgimte kryisvvpss fighlqslmf
      841 ngllyidlck ngdidycelk arfglrniia dpvtfktkss ylslatlqay tsmhlffqfk
      901 ttspdgfilf nsgdgndfia velvkgyihy vfdlgngpnv ikgnsdrpln dnqwhnvvit
      961 rdnsnthslk vdtkvvtqvi ngaknldlkg dlymaglaqg mysnlpklva srdgfqgcla
     1021 svdlngrlpd lindalhrsg qiergcegps ttcqedscan qgvcmqqweg ftcdcsmtsy
     1081 sgnqcndpga tyifgksggl ilytwpandr pstrsdrlav gfsttvkdgi lvridsapgl
     1141 gdflqlhieq gkigvvfnig tvdisikeer tpvndgkyhv vrftrnggna tlqvdnwpvn
     1201 ehyptgrqlt ifntqaqiai ggkdkgrlfq gqlsglyydg lkvlnmaaen npnikingsv
     1261 rlvgevpsil gttqttsmpp emsttvmett ttmattttrk nrstasiqpt sddlvssaec
     1321 ssddedfvec epstgrsdks lstsifeggy kahapkwesk dfrpnkvset srttttslsp
     1381 elirftasss sgmvpklpag kmnnrdlkpq pdivllplpt ayeldstklk splitspmfr
     1441 nvptanptep girrvpgase viresssttg mvvgivaaaa lcilillyam ykyrnrdegs
     1501 yqvdetrnyi snsaqsngtl mkekqqssks ghkkqknkdr eyyv
//
LOCUS       XP_011535673            1479 aa            linear   PRI 05-AUG-2025
DEFINITION  neurexin 3 isoform X27 [Homo sapiens].
ACCESSION   XP_011535673
VERSION     XP_011535673.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537371.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1479
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1479
                     /product="neurexin 3 isoform X27"
                     /calculated_mol_wt=163288
     Region          35..181
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          202..232
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          286..425
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          482..631
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          659..692
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          720..854
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          911..1039
                     /region_name="Laminin_G_2"
                     /note="Laminin G domain; pfam02210"
                     /db_xref="CDD:460494"
     Region          1103..1282
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          1405..1461
                     /region_name="Syndecan"
                     /note="Syndecan domain; pfam01034"
                     /db_xref="CDD:460035"
     Region          1425..1443
                     /region_name="4.1m"
                     /note="putative band 4.1 homologues' binding motif;
                     smart00294"
                     /db_xref="CDD:128590"
     CDS             1..1479
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /coded_by="XM_011537371.2:1006..5445"
                     /db_xref="GeneID:9369"
                     /db_xref="HGNC:HGNC:8010"
                     /db_xref="MIM:600567"
ORIGIN      
        1 msstlhsvff tlkvsillgs llglclglef mglpnqwary lrwdastrsd lsfqfktnvs
       61 tglllylddg gvcdflclsl vdgrvqlrfs mdcaetavls nkqvndsswh flmvsrdrlr
      121 tvlmldgegq sgelqpqrpy mdvvsdlflg gvptdirpsa ltldgvqamp gfkglildlk
      181 ygnseprllg srgvqmdaeg pcgerpceng gicflldghp tcdcsttgyg gklcsedvsq
      241 dpglshlmms eqgrskaree nvatfrgsey lcydlsqnpi qsssdeitls fktwqrngli
      301 lhtgksadyv nlalkdgavs lvinlgsgaf eaivepvngk fndnawhdvk vtrnlrqhsg
      361 ighamvtisv dgiltttgyt qedytmlgsd dffyvggsps tadlpgspvs nnfmgclkev
      421 vyknndirle lsrlariadt kmkiygevvf kcenvatldp infetpeayi slpkwntkrm
      481 gsisfdfrtt epnglilfth gkpqerkdar sqkntkvdff avelldgnly llldmgsgti
      541 kvkatqkkan dgewyhvdiq rdgrsgtisv nsrrtpftas geseildleg dmylgglpen
      601 raglilptel wtamlnygyv gcirdlfidg rsknirqlae mqnaagvkss csrmsakqcd
      661 sypcknnavc kdgwnrficd ctgtgywgrt cereasilsy dgsmymkiim pmvmhteaed
      721 vsfrfmsqra ygllvattsr dsadtlrlel dggrvklmvn ldcirincns skgpetlyag
      781 qklndnewht vrvvrrgksl kltvdddvae gtmvgdhtrl efhnietgim tekryisvvp
      841 ssfighlqsl mfngllyidl ckngdidyce lkarfglrni iadpvtfktk ssylslatlq
      901 aytsmhlffq fkttspdgfi lfnsgdgndf iavelvkgyi hyvfdlgngp nvikgnsdrp
      961 lndnqwhnvv itrdnsnths lkvdtkvvtq vingaknldl kgdlymagla qgmysnlpkl
     1021 vasrdgfqgc lasvdlngrl pdlindalhr sgqiergceg psttcqedsc anqgvcmqqw
     1081 egftcdcsmt sysgnqcndp gatyifgksg glilytwpan drpstrsdrl avgfsttvkd
     1141 gilvridsap glgdflqlhi eqgkigvvfn igtvdisike ertpvndgky hvvrftrngg
     1201 natlqvdnwp vnehyptgnt dnerfqmvkq kipfkynrpv eewlqekgrq ltifntqaqi
     1261 aiggkdkgrl fqgqlsglyy dglkvlnmaa ennpniking svrlvgevps ilgttqttsm
     1321 ppemsttvme ttttmatttt rknrstasiq ptsddlvssa ecssddedfv ecepstgrsa
     1381 nptepgirrv pgasevires ssttgmvvgi vaaaalcili llyamykyrn rdegsyqvde
     1441 trnyisnsaq sngtlmkekq qssksghkkq knkdreyyv
//
LOCUS       XP_011535674            1476 aa            linear   PRI 05-AUG-2025
DEFINITION  neurexin 3 isoform X28 [Homo sapiens].
ACCESSION   XP_011535674
VERSION     XP_011535674.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537372.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1476
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1476
                     /product="neurexin 3 isoform X28"
                     /calculated_mol_wt=162987
     Region          35..181
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          202..232
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          286..425
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          482..631
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          659..692
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          720..854
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          911..1039
                     /region_name="Laminin_G_2"
                     /note="Laminin G domain; pfam02210"
                     /db_xref="CDD:460494"
     Region          1103..1282
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          1402..1458
                     /region_name="Syndecan"
                     /note="Syndecan domain; pfam01034"
                     /db_xref="CDD:460035"
     Region          1422..1440
                     /region_name="4.1m"
                     /note="putative band 4.1 homologues' binding motif;
                     smart00294"
                     /db_xref="CDD:128590"
     CDS             1..1476
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /coded_by="XM_011537372.2:1006..5436"
                     /db_xref="GeneID:9369"
                     /db_xref="HGNC:HGNC:8010"
                     /db_xref="MIM:600567"
ORIGIN      
        1 msstlhsvff tlkvsillgs llglclglef mglpnqwary lrwdastrsd lsfqfktnvs
       61 tglllylddg gvcdflclsl vdgrvqlrfs mdcaetavls nkqvndsswh flmvsrdrlr
      121 tvlmldgegq sgelqpqrpy mdvvsdlflg gvptdirpsa ltldgvqamp gfkglildlk
      181 ygnseprllg srgvqmdaeg pcgerpceng gicflldghp tcdcsttgyg gklcsedvsq
      241 dpglshlmms eqgrskaree nvatfrgsey lcydlsqnpi qsssdeitls fktwqrngli
      301 lhtgksadyv nlalkdgavs lvinlgsgaf eaivepvngk fndnawhdvk vtrnlrqhsg
      361 ighamvtisv dgiltttgyt qedytmlgsd dffyvggsps tadlpgspvs nnfmgclkev
      421 vyknndirle lsrlariadt kmkiygevvf kcenvatldp infetpeayi slpkwntkrm
      481 gsisfdfrtt epnglilfth gkpqerkdar sqkntkvdff avelldgnly llldmgsgti
      541 kvkatqkkan dgewyhvdiq rdgrsgtisv nsrrtpftas geseildleg dmylgglpen
      601 raglilptel wtamlnygyv gcirdlfidg rsknirqlae mqnaagvkss csrmsakqcd
      661 sypcknnavc kdgwnrficd ctgtgywgrt cereasilsy dgsmymkiim pmvmhteaed
      721 vsfrfmsqra ygllvattsr dsadtlrlel dggrvklmvn ldcirincns skgpetlyag
      781 qklndnewht vrvvrrgksl kltvdddvae gtmvgdhtrl efhnietgim tekryisvvp
      841 ssfighlqsl mfngllyidl ckngdidyce lkarfglrni iadpvtfktk ssylslatlq
      901 aytsmhlffq fkttspdgfi lfnsgdgndf iavelvkgyi hyvfdlgngp nvikgnsdrp
      961 lndnqwhnvv itrdnsnths lkvdtkvvtq vingaknldl kgdlymagla qgmysnlpkl
     1021 vasrdgfqgc lasvdlngrl pdlindalhr sgqiergceg psttcqedsc anqgvcmqqw
     1081 egftcdcsmt sysgnqcndp gatyifgksg glilytwpan drpstrsdrl avgfsttvkd
     1141 gilvridsap glgdflqlhi eqgkigvvfn igtvdisike ertpvndgky hvvrftrngg
     1201 natlqvdnwp vnehyptgnt dnerfqmvkq kipfkynrpv eewlqekgrq ltifntqaqi
     1261 aiggkdkgrl fqgqlsglyy dglkvlnmaa ennpniking svrlvgevps ilgttqttsm
     1321 ppemsttvme ttttmatttt rknrstasiq ptsddlvssa ecssddedfv ecepstanpt
     1381 epgirrvpga seviressst tgmvvgivaa aalcililly amykyrnrde gsyqvdetrn
     1441 yisnsaqsng tlmkekqqss ksghkkqknk dreyyv
//
LOCUS       XP_047287909            1471 aa            linear   PRI 05-AUG-2025
DEFINITION  neurexin 3 isoform X29 [Homo sapiens].
ACCESSION   XP_047287909
VERSION     XP_047287909.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431953.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1471
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1471
                     /product="neurexin 3 isoform X29"
                     /calculated_mol_wt=162497
     Region          35..181
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          202..232
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          286..417
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          474..623
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          651..684
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          712..846
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          903..1031
                     /region_name="Laminin_G_2"
                     /note="Laminin G domain; pfam02210"
                     /db_xref="CDD:460494"
     Region          1095..1274
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          1397..1453
                     /region_name="Syndecan"
                     /note="Syndecan domain; pfam01034"
                     /db_xref="CDD:460035"
     Region          1417..1435
                     /region_name="4.1m"
                     /note="putative band 4.1 homologues' binding motif;
                     smart00294"
                     /db_xref="CDD:128590"
     CDS             1..1471
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /coded_by="XM_047431953.1:1006..5421"
                     /db_xref="GeneID:9369"
                     /db_xref="HGNC:HGNC:8010"
                     /db_xref="MIM:600567"
ORIGIN      
        1 msstlhsvff tlkvsillgs llglclglef mglpnqwary lrwdastrsd lsfqfktnvs
       61 tglllylddg gvcdflclsl vdgrvqlrfs mdcaetavls nkqvndsswh flmvsrdrlr
      121 tvlmldgegq sgelqpqrpy mdvvsdlflg gvptdirpsa ltldgvqamp gfkglildlk
      181 ygnseprllg srgvqmdaeg pcgerpceng gicflldghp tcdcsttgyg gklcsedvsq
      241 dpglshlmms eqgrskaree nvatfrgsey lcydlsqnpi qsssdeitls fktwqrngli
      301 lhtgksadyv nlalkdgavs lvinlgsgaf eaivepvngk fndnawhdvk vtrnlrqvti
      361 svdgiltttg ytqedytmlg sddffyvggs pstadlpgsp vsnnfmgclk evvyknndir
      421 lelsrlaria dtkmkiygev vfkcenvatl dpinfetpea yislpkwntk rmgsisfdfr
      481 ttepnglilf thgkpqerkd arsqkntkvd ffavelldgn lyllldmgsg tikvkatqkk
      541 andgewyhvd iqrdgrsgti svnsrrtpft asgeseildl egdmylgglp enraglilpt
      601 elwtamlnyg yvgcirdlfi dgrsknirql aemqnaagvk sscsrmsakq cdsypcknna
      661 vckdgwnrfi cdctgtgywg rtcereasil sydgsmymki impmvmhtea edvsfrfmsq
      721 raygllvatt srdsadtlrl eldggrvklm vnldcirinc nsskgpetly agqklndnew
      781 htvrvvrrgk slkltvdddv aegtmvgdht rlefhnietg imtekryisv vpssfighlq
      841 slmfngllyi dlckngdidy celkarfglr niiadpvtfk tkssylslat lqaytsmhlf
      901 fqfkttspdg filfnsgdgn dfiavelvkg yihyvfdlgn gpnvikgnsd rplndnqwhn
      961 vvitrdnsnt hslkvdtkvv tqvingaknl dlkgdlymag laqgmysnlp klvasrdgfq
     1021 gclasvdlng rlpdlindal hrsgqiergc egpsttcqed scanqgvcmq qwegftcdcs
     1081 mtsysgnqcn dpgatyifgk sgglilytwp andrpstrsd rlavgfsttv kdgilvrids
     1141 apglgdflql hieqgkigvv fnigtvdisi keertpvndg kyhvvrftrn ggnatlqvdn
     1201 wpvnehyptg ntdnerfqmv kqkipfkynr pveewlqekg rqltifntqa qiaiggkdkg
     1261 rlfqgqlsgl yydglkvlnm aaennpniki ngsvrlvgev psilgttqtt smppemsttv
     1321 mettttmatt ttrknrstas iqptsddlvs saecssdded fvecepstgr sanptepgir
     1381 rvpgasevir esssttgmvv givaaaalci lillyamyky rnrdegsyqv detrnyisns
     1441 aqsngtlmke kqqssksghk kqknkdreyy v
//
LOCUS       XP_047287910            1467 aa            linear   PRI 05-AUG-2025
DEFINITION  neurexin 3 isoform X30 [Homo sapiens].
ACCESSION   XP_047287910
VERSION     XP_047287910.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431954.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1467
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1467
                     /product="neurexin 3 isoform X30"
                     /calculated_mol_wt=162068
     Region          35..181
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          202..232
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          282..413
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          470..619
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          647..680
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          708..842
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          899..1027
                     /region_name="Laminin_G_2"
                     /note="Laminin G domain; pfam02210"
                     /db_xref="CDD:460494"
     Region          1091..1270
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          1393..1449
                     /region_name="Syndecan"
                     /note="Syndecan domain; pfam01034"
                     /db_xref="CDD:460035"
     Region          1413..1431
                     /region_name="4.1m"
                     /note="putative band 4.1 homologues' binding motif;
                     smart00294"
                     /db_xref="CDD:128590"
     CDS             1..1467
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /coded_by="XM_047431954.1:1006..5409"
                     /db_xref="GeneID:9369"
                     /db_xref="HGNC:HGNC:8010"
                     /db_xref="MIM:600567"
ORIGIN      
        1 msstlhsvff tlkvsillgs llglclglef mglpnqwary lrwdastrsd lsfqfktnvs
       61 tglllylddg gvcdflclsl vdgrvqlrfs mdcaetavls nkqvndsswh flmvsrdrlr
      121 tvlmldgegq sgelqpqrpy mdvvsdlflg gvptdirpsa ltldgvqamp gfkglildlk
      181 ygnseprllg srgvqmdaeg pcgerpceng gicflldghp tcdcsttgyg gklcsedvsq
      241 dpglshlmms eqareenvat frgseylcyd lsqnpiqsss deitlsfktw qrnglilhtg
      301 ksadyvnlal kdgavslvin lgsgafeaiv epvngkfndn awhdvkvtrn lrqvtisvdg
      361 iltttgytqe dytmlgsddf fyvggspsta dlpgspvsnn fmgclkevvy knndirlels
      421 rlariadtkm kiygevvfkc envatldpin fetpeayisl pkwntkrmgs isfdfrttep
      481 nglilfthgk pqerkdarsq kntkvdffav elldgnlyll ldmgsgtikv katqkkandg
      541 ewyhvdiqrd grsgtisvns rrtpftasge seildlegdm ylgglpenra glilptelwt
      601 amlnygyvgc irdlfidgrs knirqlaemq naagvksscs rmsakqcdsy pcknnavckd
      661 gwnrficdct gtgywgrtce reasilsydg smymkiimpm vmhteaedvs frfmsqrayg
      721 llvattsrds adtlrleldg grvklmvnld cirincnssk gpetlyagqk lndnewhtvr
      781 vvrrgkslkl tvdddvaegt mvgdhtrlef hnietgimte kryisvvpss fighlqslmf
      841 ngllyidlck ngdidycelk arfglrniia dpvtfktkss ylslatlqay tsmhlffqfk
      901 ttspdgfilf nsgdgndfia velvkgyihy vfdlgngpnv ikgnsdrpln dnqwhnvvit
      961 rdnsnthslk vdtkvvtqvi ngaknldlkg dlymaglaqg mysnlpklva srdgfqgcla
     1021 svdlngrlpd lindalhrsg qiergcegps ttcqedscan qgvcmqqweg ftcdcsmtsy
     1081 sgnqcndpga tyifgksggl ilytwpandr pstrsdrlav gfsttvkdgi lvridsapgl
     1141 gdflqlhieq gkigvvfnig tvdisikeer tpvndgkyhv vrftrnggna tlqvdnwpvn
     1201 ehyptgntdn erfqmvkqki pfkynrpvee wlqekgrqlt ifntqaqiai ggkdkgrlfq
     1261 gqlsglyydg lkvlnmaaen npnikingsv rlvgevpsil gttqttsmpp emsttvmett
     1321 ttmattttrk nrstasiqpt sddlvssaec ssddedfvec epstgrsanp tepgirrvpg
     1381 aseviresss ttgmvvgiva aaalcilill yamykyrnrd egsyqvdetr nyisnsaqsn
     1441 gtlmkekqqs sksghkkqkn kdreyyv
//
LOCUS       XP_016877294            1464 aa            linear   PRI 05-AUG-2025
DEFINITION  neurexin 3 isoform X31 [Homo sapiens].
ACCESSION   XP_016877294
VERSION     XP_016877294.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021805.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1464
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1464
                     /product="neurexin 3 isoform X31"
                     /calculated_mol_wt=161768
     Region          35..181
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          202..232
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          282..413
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          470..619
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          647..680
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          708..842
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          899..1027
                     /region_name="Laminin_G_2"
                     /note="Laminin G domain; pfam02210"
                     /db_xref="CDD:460494"
     Region          1091..1270
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          1390..1446
                     /region_name="Syndecan"
                     /note="Syndecan domain; pfam01034"
                     /db_xref="CDD:460035"
     Region          1410..1428
                     /region_name="4.1m"
                     /note="putative band 4.1 homologues' binding motif;
                     smart00294"
                     /db_xref="CDD:128590"
     CDS             1..1464
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /coded_by="XM_017021805.2:1006..5400"
                     /db_xref="GeneID:9369"
                     /db_xref="HGNC:HGNC:8010"
                     /db_xref="MIM:600567"
ORIGIN      
        1 msstlhsvff tlkvsillgs llglclglef mglpnqwary lrwdastrsd lsfqfktnvs
       61 tglllylddg gvcdflclsl vdgrvqlrfs mdcaetavls nkqvndsswh flmvsrdrlr
      121 tvlmldgegq sgelqpqrpy mdvvsdlflg gvptdirpsa ltldgvqamp gfkglildlk
      181 ygnseprllg srgvqmdaeg pcgerpceng gicflldghp tcdcsttgyg gklcsedvsq
      241 dpglshlmms eqareenvat frgseylcyd lsqnpiqsss deitlsfktw qrnglilhtg
      301 ksadyvnlal kdgavslvin lgsgafeaiv epvngkfndn awhdvkvtrn lrqvtisvdg
      361 iltttgytqe dytmlgsddf fyvggspsta dlpgspvsnn fmgclkevvy knndirlels
      421 rlariadtkm kiygevvfkc envatldpin fetpeayisl pkwntkrmgs isfdfrttep
      481 nglilfthgk pqerkdarsq kntkvdffav elldgnlyll ldmgsgtikv katqkkandg
      541 ewyhvdiqrd grsgtisvns rrtpftasge seildlegdm ylgglpenra glilptelwt
      601 amlnygyvgc irdlfidgrs knirqlaemq naagvksscs rmsakqcdsy pcknnavckd
      661 gwnrficdct gtgywgrtce reasilsydg smymkiimpm vmhteaedvs frfmsqrayg
      721 llvattsrds adtlrleldg grvklmvnld cirincnssk gpetlyagqk lndnewhtvr
      781 vvrrgkslkl tvdddvaegt mvgdhtrlef hnietgimte kryisvvpss fighlqslmf
      841 ngllyidlck ngdidycelk arfglrniia dpvtfktkss ylslatlqay tsmhlffqfk
      901 ttspdgfilf nsgdgndfia velvkgyihy vfdlgngpnv ikgnsdrpln dnqwhnvvit
      961 rdnsnthslk vdtkvvtqvi ngaknldlkg dlymaglaqg mysnlpklva srdgfqgcla
     1021 svdlngrlpd lindalhrsg qiergcegps ttcqedscan qgvcmqqweg ftcdcsmtsy
     1081 sgnqcndpga tyifgksggl ilytwpandr pstrsdrlav gfsttvkdgi lvridsapgl
     1141 gdflqlhieq gkigvvfnig tvdisikeer tpvndgkyhv vrftrnggna tlqvdnwpvn
     1201 ehyptgntdn erfqmvkqki pfkynrpvee wlqekgrqlt ifntqaqiai ggkdkgrlfq
     1261 gqlsglyydg lkvlnmaaen npnikingsv rlvgevpsil gttqttsmpp emsttvmett
     1321 ttmattttrk nrstasiqpt sddlvssaec ssddedfvec epstanptep girrvpgase
     1381 viresssttg mvvgivaaaa lcilillyam ykyrnrdegs yqvdetrnyi snsaqsngtl
     1441 mkekqqssks ghkkqknkdr eyyv
//
LOCUS       XP_047287911            1458 aa            linear   PRI 05-AUG-2025
DEFINITION  neurexin 3 isoform X32 [Homo sapiens].
ACCESSION   XP_047287911
VERSION     XP_047287911.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431955.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1458
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1458
                     /product="neurexin 3 isoform X32"
                     /calculated_mol_wt=161019
     Region          35..181
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          202..232
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          282..413
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          470..619
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          647..680
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          708..833
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          890..1018
                     /region_name="Laminin_G_2"
                     /note="Laminin G domain; pfam02210"
                     /db_xref="CDD:460494"
     Region          1082..1261
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          1384..1440
                     /region_name="Syndecan"
                     /note="Syndecan domain; pfam01034"
                     /db_xref="CDD:460035"
     Region          1404..1422
                     /region_name="4.1m"
                     /note="putative band 4.1 homologues' binding motif;
                     smart00294"
                     /db_xref="CDD:128590"
     CDS             1..1458
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /coded_by="XM_047431955.1:1006..5382"
                     /db_xref="GeneID:9369"
                     /db_xref="HGNC:HGNC:8010"
                     /db_xref="MIM:600567"
ORIGIN      
        1 msstlhsvff tlkvsillgs llglclglef mglpnqwary lrwdastrsd lsfqfktnvs
       61 tglllylddg gvcdflclsl vdgrvqlrfs mdcaetavls nkqvndsswh flmvsrdrlr
      121 tvlmldgegq sgelqpqrpy mdvvsdlflg gvptdirpsa ltldgvqamp gfkglildlk
      181 ygnseprllg srgvqmdaeg pcgerpceng gicflldghp tcdcsttgyg gklcsedvsq
      241 dpglshlmms eqareenvat frgseylcyd lsqnpiqsss deitlsfktw qrnglilhtg
      301 ksadyvnlal kdgavslvin lgsgafeaiv epvngkfndn awhdvkvtrn lrqvtisvdg
      361 iltttgytqe dytmlgsddf fyvggspsta dlpgspvsnn fmgclkevvy knndirlels
      421 rlariadtkm kiygevvfkc envatldpin fetpeayisl pkwntkrmgs isfdfrttep
      481 nglilfthgk pqerkdarsq kntkvdffav elldgnlyll ldmgsgtikv katqkkandg
      541 ewyhvdiqrd grsgtisvns rrtpftasge seildlegdm ylgglpenra glilptelwt
      601 amlnygyvgc irdlfidgrs knirqlaemq naagvksscs rmsakqcdsy pcknnavckd
      661 gwnrficdct gtgywgrtce reasilsydg smymkiimpm vmhteaedvs frfmsqrayg
      721 llvattsrds adtlrleldg grvklmvnlg kgpetlyagq klndnewhtv rvvrrgkslk
      781 ltvdddvaeg tmvgdhtrle fhnietgimt ekryisvvps sfighlqslm fngllyidlc
      841 kngdidycel karfglrnii adpvtfktks sylslatlqa ytsmhlffqf kttspdgfil
      901 fnsgdgndfi avelvkgyih yvfdlgngpn vikgnsdrpl ndnqwhnvvi trdnsnthsl
      961 kvdtkvvtqv ingaknldlk gdlymaglaq gmysnlpklv asrdgfqgcl asvdlngrlp
     1021 dlindalhrs gqiergcegp sttcqedsca nqgvcmqqwe gftcdcsmts ysgnqcndpg
     1081 atyifgksgg lilytwpand rpstrsdrla vgfsttvkdg ilvridsapg lgdflqlhie
     1141 qgkigvvfni gtvdisikee rtpvndgkyh vvrftrnggn atlqvdnwpv nehyptgntd
     1201 nerfqmvkqk ipfkynrpve ewlqekgrql tifntqaqia iggkdkgrlf qgqlsglyyd
     1261 glkvlnmaae nnpnikings vrlvgevpsi lgttqttsmp pemsttvmet tttmattttr
     1321 knrstasiqp tsddlvssae cssddedfve cepstgrsan ptepgirrvp gaseviress
     1381 sttgmvvgiv aaaalcilil lyamykyrnr degsyqvdet rnyisnsaqs ngtlmkekqq
     1441 ssksghkkqk nkdreyyv
//
LOCUS       XP_047287912            1455 aa            linear   PRI 05-AUG-2025
DEFINITION  neurexin 3 isoform X33 [Homo sapiens].
ACCESSION   XP_047287912
VERSION     XP_047287912.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431956.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1455
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1455
                     /product="neurexin 3 isoform X33"
                     /calculated_mol_wt=160719
     Region          35..181
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          202..232
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          282..413
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          470..619
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          647..680
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          708..833
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          890..1018
                     /region_name="Laminin_G_2"
                     /note="Laminin G domain; pfam02210"
                     /db_xref="CDD:460494"
     Region          1082..1261
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          1381..1437
                     /region_name="Syndecan"
                     /note="Syndecan domain; pfam01034"
                     /db_xref="CDD:460035"
     Region          1401..1419
                     /region_name="4.1m"
                     /note="putative band 4.1 homologues' binding motif;
                     smart00294"
                     /db_xref="CDD:128590"
     CDS             1..1455
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /coded_by="XM_047431956.1:1006..5373"
                     /db_xref="GeneID:9369"
                     /db_xref="HGNC:HGNC:8010"
                     /db_xref="MIM:600567"
ORIGIN      
        1 msstlhsvff tlkvsillgs llglclglef mglpnqwary lrwdastrsd lsfqfktnvs
       61 tglllylddg gvcdflclsl vdgrvqlrfs mdcaetavls nkqvndsswh flmvsrdrlr
      121 tvlmldgegq sgelqpqrpy mdvvsdlflg gvptdirpsa ltldgvqamp gfkglildlk
      181 ygnseprllg srgvqmdaeg pcgerpceng gicflldghp tcdcsttgyg gklcsedvsq
      241 dpglshlmms eqareenvat frgseylcyd lsqnpiqsss deitlsfktw qrnglilhtg
      301 ksadyvnlal kdgavslvin lgsgafeaiv epvngkfndn awhdvkvtrn lrqvtisvdg
      361 iltttgytqe dytmlgsddf fyvggspsta dlpgspvsnn fmgclkevvy knndirlels
      421 rlariadtkm kiygevvfkc envatldpin fetpeayisl pkwntkrmgs isfdfrttep
      481 nglilfthgk pqerkdarsq kntkvdffav elldgnlyll ldmgsgtikv katqkkandg
      541 ewyhvdiqrd grsgtisvns rrtpftasge seildlegdm ylgglpenra glilptelwt
      601 amlnygyvgc irdlfidgrs knirqlaemq naagvksscs rmsakqcdsy pcknnavckd
      661 gwnrficdct gtgywgrtce reasilsydg smymkiimpm vmhteaedvs frfmsqrayg
      721 llvattsrds adtlrleldg grvklmvnlg kgpetlyagq klndnewhtv rvvrrgkslk
      781 ltvdddvaeg tmvgdhtrle fhnietgimt ekryisvvps sfighlqslm fngllyidlc
      841 kngdidycel karfglrnii adpvtfktks sylslatlqa ytsmhlffqf kttspdgfil
      901 fnsgdgndfi avelvkgyih yvfdlgngpn vikgnsdrpl ndnqwhnvvi trdnsnthsl
      961 kvdtkvvtqv ingaknldlk gdlymaglaq gmysnlpklv asrdgfqgcl asvdlngrlp
     1021 dlindalhrs gqiergcegp sttcqedsca nqgvcmqqwe gftcdcsmts ysgnqcndpg
     1081 atyifgksgg lilytwpand rpstrsdrla vgfsttvkdg ilvridsapg lgdflqlhie
     1141 qgkigvvfni gtvdisikee rtpvndgkyh vvrftrnggn atlqvdnwpv nehyptgntd
     1201 nerfqmvkqk ipfkynrpve ewlqekgrql tifntqaqia iggkdkgrlf qgqlsglyyd
     1261 glkvlnmaae nnpnikings vrlvgevpsi lgttqttsmp pemsttvmet tttmattttr
     1321 knrstasiqp tsddlvssae cssddedfve cepstanpte pgirrvpgas eviressstt
     1381 gmvvgivaaa alcilillya mykyrnrdeg syqvdetrny isnsaqsngt lmkekqqssk
     1441 sghkkqknkd reyyv
//
LOCUS       XP_047287913            1445 aa            linear   PRI 05-AUG-2025
DEFINITION  neurexin 3 isoform X34 [Homo sapiens].
ACCESSION   XP_047287913
VERSION     XP_047287913.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431957.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1445
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1445
                     /product="neurexin 3 isoform X34"
                     /calculated_mol_wt=159124
     Region          35..181
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          202..232
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          282..421
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          478..627
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          655..688
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          716..850
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          907..1035
                     /region_name="Laminin_G_2"
                     /note="Laminin G domain; pfam02210"
                     /db_xref="CDD:460494"
     Region          1099..1248
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          1371..1427
                     /region_name="Syndecan"
                     /note="Syndecan domain; pfam01034"
                     /db_xref="CDD:460035"
     Region          1391..1409
                     /region_name="4.1m"
                     /note="putative band 4.1 homologues' binding motif;
                     smart00294"
                     /db_xref="CDD:128590"
     CDS             1..1445
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /coded_by="XM_047431957.1:1006..5343"
                     /db_xref="GeneID:9369"
                     /db_xref="HGNC:HGNC:8010"
                     /db_xref="MIM:600567"
ORIGIN      
        1 msstlhsvff tlkvsillgs llglclglef mglpnqwary lrwdastrsd lsfqfktnvs
       61 tglllylddg gvcdflclsl vdgrvqlrfs mdcaetavls nkqvndsswh flmvsrdrlr
      121 tvlmldgegq sgelqpqrpy mdvvsdlflg gvptdirpsa ltldgvqamp gfkglildlk
      181 ygnseprllg srgvqmdaeg pcgerpceng gicflldghp tcdcsttgyg gklcsedvsq
      241 dpglshlmms eqareenvat frgseylcyd lsqnpiqsss deitlsfktw qrnglilhtg
      301 ksadyvnlal kdgavslvin lgsgafeaiv epvngkfndn awhdvkvtrn lrqhsgigha
      361 mvtisvdgil tttgytqedy tmlgsddffy vggspstadl pgspvsnnfm gclkevvykn
      421 ndirlelsrl ariadtkmki ygevvfkcen vatldpinfe tpeayislpk wntkrmgsis
      481 fdfrttepng lilfthgkpq erkdarsqkn tkvdffavel ldgnlyllld mgsgtikvka
      541 tqkkandgew yhvdiqrdgr sgtisvnsrr tpftasgese ildlegdmyl gglpenragl
      601 ilptelwtam lnygyvgcir dlfidgrskn irqlaemqna agvksscsrm sakqcdsypc
      661 knnavckdgw nrficdctgt gywgrtcere asilsydgsm ymkiimpmvm hteaedvsfr
      721 fmsqraygll vattsrdsad tlrleldggr vklmvnldci rincnsskgp etlyagqkln
      781 dnewhtvrvv rrgkslkltv dddvaegtmv gdhtrlefhn ietgimtekr yisvvpssfi
      841 ghlqslmfng llyidlckng didycelkar fglrniiadp vtfktkssyl slatlqayts
      901 mhlffqfktt spdgfilfns gdgndfiave lvkgyihyvf dlgngpnvik gnsdrplndn
      961 qwhnvvitrd nsnthslkvd tkvvtqving aknldlkgdl ymaglaqgmy snlpklvasr
     1021 dgfqgclasv dlngrlpdli ndalhrsgqi ergcegpstt cqedscanqg vcmqqwegft
     1081 cdcsmtsysg nqcndpgaty ifgksgglil ytwpandrps trsdrlavgf sttvkdgilv
     1141 ridsapglgd flqlhieqgk igvvfnigtv disikeertp vndgkyhvvr ftrnggnatl
     1201 qvdnwpvneh yptgrqltif ntqaqiaigg kdkgrlfqgq lsglyydglk vlnmaaennp
     1261 nikingsvrl vgevpsilgt tqttsmppem sttvmetttt mattttrknr stasiqptsd
     1321 dlvssaecss ddedfvecep stgrsanpte pgirrvpgas eviressstt gmvvgivaaa
     1381 alcilillya mykyrnrdeg syqvdetrny isnsaqsngt lmkekqqssk sghkkqknkd
     1441 reyyv
//
LOCUS       XP_047287914            1437 aa            linear   PRI 05-AUG-2025
DEFINITION  neurexin 3 isoform X35 [Homo sapiens].
ACCESSION   XP_047287914
VERSION     XP_047287914.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431958.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1437
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1437
                     /product="neurexin 3 isoform X35"
                     /calculated_mol_wt=158333
     Region          35..181
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          202..232
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          282..413
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          470..619
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          647..680
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          708..842
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          899..1027
                     /region_name="Laminin_G_2"
                     /note="Laminin G domain; pfam02210"
                     /db_xref="CDD:460494"
     Region          1091..1240
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          1363..1419
                     /region_name="Syndecan"
                     /note="Syndecan domain; pfam01034"
                     /db_xref="CDD:460035"
     Region          1383..1401
                     /region_name="4.1m"
                     /note="putative band 4.1 homologues' binding motif;
                     smart00294"
                     /db_xref="CDD:128590"
     CDS             1..1437
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /coded_by="XM_047431958.1:1006..5319"
                     /db_xref="GeneID:9369"
                     /db_xref="HGNC:HGNC:8010"
                     /db_xref="MIM:600567"
ORIGIN      
        1 msstlhsvff tlkvsillgs llglclglef mglpnqwary lrwdastrsd lsfqfktnvs
       61 tglllylddg gvcdflclsl vdgrvqlrfs mdcaetavls nkqvndsswh flmvsrdrlr
      121 tvlmldgegq sgelqpqrpy mdvvsdlflg gvptdirpsa ltldgvqamp gfkglildlk
      181 ygnseprllg srgvqmdaeg pcgerpceng gicflldghp tcdcsttgyg gklcsedvsq
      241 dpglshlmms eqareenvat frgseylcyd lsqnpiqsss deitlsfktw qrnglilhtg
      301 ksadyvnlal kdgavslvin lgsgafeaiv epvngkfndn awhdvkvtrn lrqvtisvdg
      361 iltttgytqe dytmlgsddf fyvggspsta dlpgspvsnn fmgclkevvy knndirlels
      421 rlariadtkm kiygevvfkc envatldpin fetpeayisl pkwntkrmgs isfdfrttep
      481 nglilfthgk pqerkdarsq kntkvdffav elldgnlyll ldmgsgtikv katqkkandg
      541 ewyhvdiqrd grsgtisvns rrtpftasge seildlegdm ylgglpenra glilptelwt
      601 amlnygyvgc irdlfidgrs knirqlaemq naagvksscs rmsakqcdsy pcknnavckd
      661 gwnrficdct gtgywgrtce reasilsydg smymkiimpm vmhteaedvs frfmsqrayg
      721 llvattsrds adtlrleldg grvklmvnld cirincnssk gpetlyagqk lndnewhtvr
      781 vvrrgkslkl tvdddvaegt mvgdhtrlef hnietgimte kryisvvpss fighlqslmf
      841 ngllyidlck ngdidycelk arfglrniia dpvtfktkss ylslatlqay tsmhlffqfk
      901 ttspdgfilf nsgdgndfia velvkgyihy vfdlgngpnv ikgnsdrpln dnqwhnvvit
      961 rdnsnthslk vdtkvvtqvi ngaknldlkg dlymaglaqg mysnlpklva srdgfqgcla
     1021 svdlngrlpd lindalhrsg qiergcegps ttcqedscan qgvcmqqweg ftcdcsmtsy
     1081 sgnqcndpga tyifgksggl ilytwpandr pstrsdrlav gfsttvkdgi lvridsapgl
     1141 gdflqlhieq gkigvvfnig tvdisikeer tpvndgkyhv vrftrnggna tlqvdnwpvn
     1201 ehyptgrqlt ifntqaqiai ggkdkgrlfq gqlsglyydg lkvlnmaaen npnikingsv
     1261 rlvgevpsil gttqttsmpp emsttvmett ttmattttrk nrstasiqpt sddlvssaec
     1321 ssddedfvec epstgrsanp tepgirrvpg aseviresss ttgmvvgiva aaalcilill
     1381 yamykyrnrd egsyqvdetr nyisnsaqsn gtlmkekqqs sksghkkqkn kdreyyv
//
LOCUS       XP_047287915            1434 aa            linear   PRI 05-AUG-2025
DEFINITION  neurexin 3 isoform X36 [Homo sapiens].
ACCESSION   XP_047287915
VERSION     XP_047287915.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431959.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1434
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1434
                     /product="neurexin 3 isoform X36"
                     /calculated_mol_wt=158033
     Region          35..181
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          202..232
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          282..413
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          470..619
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          647..680
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          708..842
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          899..1027
                     /region_name="Laminin_G_2"
                     /note="Laminin G domain; pfam02210"
                     /db_xref="CDD:460494"
     Region          1091..1240
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          1360..1416
                     /region_name="Syndecan"
                     /note="Syndecan domain; pfam01034"
                     /db_xref="CDD:460035"
     Region          1380..1398
                     /region_name="4.1m"
                     /note="putative band 4.1 homologues' binding motif;
                     smart00294"
                     /db_xref="CDD:128590"
     CDS             1..1434
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /coded_by="XM_047431959.1:1006..5310"
                     /db_xref="GeneID:9369"
                     /db_xref="HGNC:HGNC:8010"
                     /db_xref="MIM:600567"
ORIGIN      
        1 msstlhsvff tlkvsillgs llglclglef mglpnqwary lrwdastrsd lsfqfktnvs
       61 tglllylddg gvcdflclsl vdgrvqlrfs mdcaetavls nkqvndsswh flmvsrdrlr
      121 tvlmldgegq sgelqpqrpy mdvvsdlflg gvptdirpsa ltldgvqamp gfkglildlk
      181 ygnseprllg srgvqmdaeg pcgerpceng gicflldghp tcdcsttgyg gklcsedvsq
      241 dpglshlmms eqareenvat frgseylcyd lsqnpiqsss deitlsfktw qrnglilhtg
      301 ksadyvnlal kdgavslvin lgsgafeaiv epvngkfndn awhdvkvtrn lrqvtisvdg
      361 iltttgytqe dytmlgsddf fyvggspsta dlpgspvsnn fmgclkevvy knndirlels
      421 rlariadtkm kiygevvfkc envatldpin fetpeayisl pkwntkrmgs isfdfrttep
      481 nglilfthgk pqerkdarsq kntkvdffav elldgnlyll ldmgsgtikv katqkkandg
      541 ewyhvdiqrd grsgtisvns rrtpftasge seildlegdm ylgglpenra glilptelwt
      601 amlnygyvgc irdlfidgrs knirqlaemq naagvksscs rmsakqcdsy pcknnavckd
      661 gwnrficdct gtgywgrtce reasilsydg smymkiimpm vmhteaedvs frfmsqrayg
      721 llvattsrds adtlrleldg grvklmvnld cirincnssk gpetlyagqk lndnewhtvr
      781 vvrrgkslkl tvdddvaegt mvgdhtrlef hnietgimte kryisvvpss fighlqslmf
      841 ngllyidlck ngdidycelk arfglrniia dpvtfktkss ylslatlqay tsmhlffqfk
      901 ttspdgfilf nsgdgndfia velvkgyihy vfdlgngpnv ikgnsdrpln dnqwhnvvit
      961 rdnsnthslk vdtkvvtqvi ngaknldlkg dlymaglaqg mysnlpklva srdgfqgcla
     1021 svdlngrlpd lindalhrsg qiergcegps ttcqedscan qgvcmqqweg ftcdcsmtsy
     1081 sgnqcndpga tyifgksggl ilytwpandr pstrsdrlav gfsttvkdgi lvridsapgl
     1141 gdflqlhieq gkigvvfnig tvdisikeer tpvndgkyhv vrftrnggna tlqvdnwpvn
     1201 ehyptgrqlt ifntqaqiai ggkdkgrlfq gqlsglyydg lkvlnmaaen npnikingsv
     1261 rlvgevpsil gttqttsmpp emsttvmett ttmattttrk nrstasiqpt sddlvssaec
     1321 ssddedfvec epstanptep girrvpgase viresssttg mvvgivaaaa lcilillyam
     1381 ykyrnrdegs yqvdetrnyi snsaqsngtl mkekqqssks ghkkqknkdr eyyv
//
LOCUS       XP_024305521            1425 aa            linear   PRI 05-AUG-2025
DEFINITION  neurexin 3 isoform X37 [Homo sapiens].
ACCESSION   XP_024305521
VERSION     XP_024305521.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449753.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1425
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1425
                     /product="neurexin 3 isoform X37"
                     /calculated_mol_wt=156983
     Region          35..181
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          202..232
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          282..413
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          470..619
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          647..680
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          708..833
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          890..1018
                     /region_name="Laminin_G_2"
                     /note="Laminin G domain; pfam02210"
                     /db_xref="CDD:460494"
     Region          1082..1231
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          1351..1407
                     /region_name="Syndecan"
                     /note="Syndecan domain; pfam01034"
                     /db_xref="CDD:460035"
     Region          1371..1389
                     /region_name="4.1m"
                     /note="putative band 4.1 homologues' binding motif;
                     smart00294"
                     /db_xref="CDD:128590"
     CDS             1..1425
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /coded_by="XM_024449753.2:1006..5283"
                     /db_xref="GeneID:9369"
                     /db_xref="HGNC:HGNC:8010"
                     /db_xref="MIM:600567"
ORIGIN      
        1 msstlhsvff tlkvsillgs llglclglef mglpnqwary lrwdastrsd lsfqfktnvs
       61 tglllylddg gvcdflclsl vdgrvqlrfs mdcaetavls nkqvndsswh flmvsrdrlr
      121 tvlmldgegq sgelqpqrpy mdvvsdlflg gvptdirpsa ltldgvqamp gfkglildlk
      181 ygnseprllg srgvqmdaeg pcgerpceng gicflldghp tcdcsttgyg gklcsedvsq
      241 dpglshlmms eqareenvat frgseylcyd lsqnpiqsss deitlsfktw qrnglilhtg
      301 ksadyvnlal kdgavslvin lgsgafeaiv epvngkfndn awhdvkvtrn lrqvtisvdg
      361 iltttgytqe dytmlgsddf fyvggspsta dlpgspvsnn fmgclkevvy knndirlels
      421 rlariadtkm kiygevvfkc envatldpin fetpeayisl pkwntkrmgs isfdfrttep
      481 nglilfthgk pqerkdarsq kntkvdffav elldgnlyll ldmgsgtikv katqkkandg
      541 ewyhvdiqrd grsgtisvns rrtpftasge seildlegdm ylgglpenra glilptelwt
      601 amlnygyvgc irdlfidgrs knirqlaemq naagvksscs rmsakqcdsy pcknnavckd
      661 gwnrficdct gtgywgrtce reasilsydg smymkiimpm vmhteaedvs frfmsqrayg
      721 llvattsrds adtlrleldg grvklmvnlg kgpetlyagq klndnewhtv rvvrrgkslk
      781 ltvdddvaeg tmvgdhtrle fhnietgimt ekryisvvps sfighlqslm fngllyidlc
      841 kngdidycel karfglrnii adpvtfktks sylslatlqa ytsmhlffqf kttspdgfil
      901 fnsgdgndfi avelvkgyih yvfdlgngpn vikgnsdrpl ndnqwhnvvi trdnsnthsl
      961 kvdtkvvtqv ingaknldlk gdlymaglaq gmysnlpklv asrdgfqgcl asvdlngrlp
     1021 dlindalhrs gqiergcegp sttcqedsca nqgvcmqqwe gftcdcsmts ysgnqcndpg
     1081 atyifgksgg lilytwpand rpstrsdrla vgfsttvkdg ilvridsapg lgdflqlhie
     1141 qgkigvvfni gtvdisikee rtpvndgkyh vvrftrnggn atlqvdnwpv nehyptgrql
     1201 tifntqaqia iggkdkgrlf qgqlsglyyd glkvlnmaae nnpnikings vrlvgevpsi
     1261 lgttqttsmp pemsttvmet tttmattttr knrstasiqp tsddlvssae cssddedfve
     1321 cepstanpte pgirrvpgas eviressstt gmvvgivaaa alcilillya mykyrnrdeg
     1381 syqvdetrny isnsaqsngt lmkekqqssk sghkkqknkd reyyv
//
LOCUS       XP_047287916            1412 aa            linear   PRI 05-AUG-2025
DEFINITION  neurexin 3 isoform X38 [Homo sapiens].
ACCESSION   XP_047287916
VERSION     XP_047287916.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431960.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1412
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1412
                     /product="neurexin 3 isoform X38"
                     /calculated_mol_wt=155936
     Region          35..181
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          202..232
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          286..425
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          482..631
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          659..692
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          720..854
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          911..1039
                     /region_name="Laminin_G_2"
                     /note="Laminin G domain; pfam02210"
                     /db_xref="CDD:460494"
     Region          1103..1282
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     CDS             1..1412
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /coded_by="XM_047431960.1:1006..5244"
                     /db_xref="GeneID:9369"
                     /db_xref="HGNC:HGNC:8010"
                     /db_xref="MIM:600567"
ORIGIN      
        1 msstlhsvff tlkvsillgs llglclglef mglpnqwary lrwdastrsd lsfqfktnvs
       61 tglllylddg gvcdflclsl vdgrvqlrfs mdcaetavls nkqvndsswh flmvsrdrlr
      121 tvlmldgegq sgelqpqrpy mdvvsdlflg gvptdirpsa ltldgvqamp gfkglildlk
      181 ygnseprllg srgvqmdaeg pcgerpceng gicflldghp tcdcsttgyg gklcsedvsq
      241 dpglshlmms eqgrskaree nvatfrgsey lcydlsqnpi qsssdeitls fktwqrngli
      301 lhtgksadyv nlalkdgavs lvinlgsgaf eaivepvngk fndnawhdvk vtrnlrqhsg
      361 ighamvtisv dgiltttgyt qedytmlgsd dffyvggsps tadlpgspvs nnfmgclkev
      421 vyknndirle lsrlariadt kmkiygevvf kcenvatldp infetpeayi slpkwntkrm
      481 gsisfdfrtt epnglilfth gkpqerkdar sqkntkvdff avelldgnly llldmgsgti
      541 kvkatqkkan dgewyhvdiq rdgrsgtisv nsrrtpftas geseildleg dmylgglpen
      601 raglilptel wtamlnygyv gcirdlfidg rsknirqlae mqnaagvkss csrmsakqcd
      661 sypcknnavc kdgwnrficd ctgtgywgrt cereasilsy dgsmymkiim pmvmhteaed
      721 vsfrfmsqra ygllvattsr dsadtlrlel dggrvklmvn ldcirincns skgpetlyag
      781 qklndnewht vrvvrrgksl kltvdddvae gtmvgdhtrl efhnietgim tekryisvvp
      841 ssfighlqsl mfngllyidl ckngdidyce lkarfglrni iadpvtfktk ssylslatlq
      901 aytsmhlffq fkttspdgfi lfnsgdgndf iavelvkgyi hyvfdlgngp nvikgnsdrp
      961 lndnqwhnvv itrdnsnths lkvdtkvvtq vingaknldl kgdlymagla qgmysnlpkl
     1021 vasrdgfqgc lasvdlngrl pdlindalhr sgqiergceg psttcqedsc anqgvcmqqw
     1081 egftcdcsmt sysgnqcndp gatyifgksg glilytwpan drpstrsdrl avgfsttvkd
     1141 gilvridsap glgdflqlhi eqgkigvvfn igtvdisike ertpvndgky hvvrftrngg
     1201 natlqvdnwp vnehyptgnt dnerfqmvkq kipfkynrpv eewlqekgrq ltifntqaqi
     1261 aiggkdkgrl fqgqlsglyy dglkvlnmaa ennpniking svrlvgevps ilgttqttsm
     1321 ppemsttvme ttttmatttt rknrstasiq ptsddlvssa ecssddedfv ecepstarss
     1381 naarslraal twtwrltytf tpiifiscvv hs
//
LOCUS       XP_047287917            1408 aa            linear   PRI 05-AUG-2025
DEFINITION  neurexin 3 isoform X39 [Homo sapiens].
ACCESSION   XP_047287917
VERSION     XP_047287917.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431961.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1408
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1408
                     /product="neurexin 3 isoform X39"
                     /calculated_mol_wt=155508
     Region          35..181
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          202..232
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          282..421
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          478..627
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          655..688
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          716..850
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          907..1035
                     /region_name="Laminin_G_2"
                     /note="Laminin G domain; pfam02210"
                     /db_xref="CDD:460494"
     Region          1099..1278
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     CDS             1..1408
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /coded_by="XM_047431961.1:1006..5232"
                     /db_xref="GeneID:9369"
                     /db_xref="HGNC:HGNC:8010"
                     /db_xref="MIM:600567"
ORIGIN      
        1 msstlhsvff tlkvsillgs llglclglef mglpnqwary lrwdastrsd lsfqfktnvs
       61 tglllylddg gvcdflclsl vdgrvqlrfs mdcaetavls nkqvndsswh flmvsrdrlr
      121 tvlmldgegq sgelqpqrpy mdvvsdlflg gvptdirpsa ltldgvqamp gfkglildlk
      181 ygnseprllg srgvqmdaeg pcgerpceng gicflldghp tcdcsttgyg gklcsedvsq
      241 dpglshlmms eqareenvat frgseylcyd lsqnpiqsss deitlsfktw qrnglilhtg
      301 ksadyvnlal kdgavslvin lgsgafeaiv epvngkfndn awhdvkvtrn lrqhsgigha
      361 mvtisvdgil tttgytqedy tmlgsddffy vggspstadl pgspvsnnfm gclkevvykn
      421 ndirlelsrl ariadtkmki ygevvfkcen vatldpinfe tpeayislpk wntkrmgsis
      481 fdfrttepng lilfthgkpq erkdarsqkn tkvdffavel ldgnlyllld mgsgtikvka
      541 tqkkandgew yhvdiqrdgr sgtisvnsrr tpftasgese ildlegdmyl gglpenragl
      601 ilptelwtam lnygyvgcir dlfidgrskn irqlaemqna agvksscsrm sakqcdsypc
      661 knnavckdgw nrficdctgt gywgrtcere asilsydgsm ymkiimpmvm hteaedvsfr
      721 fmsqraygll vattsrdsad tlrleldggr vklmvnldci rincnsskgp etlyagqkln
      781 dnewhtvrvv rrgkslkltv dddvaegtmv gdhtrlefhn ietgimtekr yisvvpssfi
      841 ghlqslmfng llyidlckng didycelkar fglrniiadp vtfktkssyl slatlqayts
      901 mhlffqfktt spdgfilfns gdgndfiave lvkgyihyvf dlgngpnvik gnsdrplndn
      961 qwhnvvitrd nsnthslkvd tkvvtqving aknldlkgdl ymaglaqgmy snlpklvasr
     1021 dgfqgclasv dlngrlpdli ndalhrsgqi ergcegpstt cqedscanqg vcmqqwegft
     1081 cdcsmtsysg nqcndpgaty ifgksgglil ytwpandrps trsdrlavgf sttvkdgilv
     1141 ridsapglgd flqlhieqgk igvvfnigtv disikeertp vndgkyhvvr ftrnggnatl
     1201 qvdnwpvneh yptgntdner fqmvkqkipf kynrpveewl qekgrqltif ntqaqiaigg
     1261 kdkgrlfqgq lsglyydglk vlnmaaennp nikingsvrl vgevpsilgt tqttsmppem
     1321 sttvmetttt mattttrknr stasiqptsd dlvssaecss ddedfvecep starssnaar
     1381 slraaltwtw rltytftpii fiscvvhs
//
LOCUS       XP_047287919            1391 aa            linear   PRI 05-AUG-2025
DEFINITION  neurexin 3 isoform X40 [Homo sapiens].
ACCESSION   XP_047287919
VERSION     XP_047287919.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431963.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1391
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1391
                     /product="neurexin 3 isoform X40"
                     /calculated_mol_wt=153668
     Region          35..181
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          202..232
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          282..413
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          470..619
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          647..680
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          708..833
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          890..1018
                     /region_name="Laminin_G_2"
                     /note="Laminin G domain; pfam02210"
                     /db_xref="CDD:460494"
     Region          1082..>1201
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     CDS             1..1391
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /coded_by="XM_047431963.1:1006..5181"
                     /db_xref="GeneID:9369"
                     /db_xref="HGNC:HGNC:8010"
                     /db_xref="MIM:600567"
ORIGIN      
        1 msstlhsvff tlkvsillgs llglclglef mglpnqwary lrwdastrsd lsfqfktnvs
       61 tglllylddg gvcdflclsl vdgrvqlrfs mdcaetavls nkqvndsswh flmvsrdrlr
      121 tvlmldgegq sgelqpqrpy mdvvsdlflg gvptdirpsa ltldgvqamp gfkglildlk
      181 ygnseprllg srgvqmdaeg pcgerpceng gicflldghp tcdcsttgyg gklcsedvsq
      241 dpglshlmms eqareenvat frgseylcyd lsqnpiqsss deitlsfktw qrnglilhtg
      301 ksadyvnlal kdgavslvin lgsgafeaiv epvngkfndn awhdvkvtrn lrqvtisvdg
      361 iltttgytqe dytmlgsddf fyvggspsta dlpgspvsnn fmgclkevvy knndirlels
      421 rlariadtkm kiygevvfkc envatldpin fetpeayisl pkwntkrmgs isfdfrttep
      481 nglilfthgk pqerkdarsq kntkvdffav elldgnlyll ldmgsgtikv katqkkandg
      541 ewyhvdiqrd grsgtisvns rrtpftasge seildlegdm ylgglpenra glilptelwt
      601 amlnygyvgc irdlfidgrs knirqlaemq naagvksscs rmsakqcdsy pcknnavckd
      661 gwnrficdct gtgywgrtce reasilsydg smymkiimpm vmhteaedvs frfmsqrayg
      721 llvattsrds adtlrleldg grvklmvnlg kgpetlyagq klndnewhtv rvvrrgkslk
      781 ltvdddvaeg tmvgdhtrle fhnietgimt ekryisvvps sfighlqslm fngllyidlc
      841 kngdidycel karfglrnii adpvtfktks sylslatlqa ytsmhlffqf kttspdgfil
      901 fnsgdgndfi avelvkgyih yvfdlgngpn vikgnsdrpl ndnqwhnvvi trdnsnthsl
      961 kvdtkvvtqv ingaknldlk gdlymaglaq gmysnlpklv asrdgfqgcl asvdlngrlp
     1021 dlindalhrs gqiergcegp sttcqedsca nqgvcmqqwe gftcdcsmts ysgnqcndpg
     1081 atyifgksgg lilytwpand rpstrsdrla vgfsttvkdg ilvridsapg lgdflqlhie
     1141 qgkigvvfni gtvdisikee rtpvndgkyh vvrftrnggn atlqvdnwpv nehyptgntd
     1201 nerfqmvkqk ipfkynrpve ewlqekgrql tifntqaqia iggkdkgrlf qgqlsglyyd
     1261 glkvlnmaae nnpnikings vrlvgevpsi lgttqttsmp pemsttvmet tttmattttr
     1321 knrstasiqp tsddlvssae cssddedfve cepstarssn aarslraalt wtwrltytft
     1381 piifiscvvh s
//
LOCUS       XP_047287920            1370 aa            linear   PRI 05-AUG-2025
DEFINITION  neurexin 3 isoform X41 [Homo sapiens].
ACCESSION   XP_047287920
VERSION     XP_047287920.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431964.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1370
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1370
                     /product="neurexin 3 isoform X41"
                     /calculated_mol_wt=150982
     Region          35..181
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          202..232
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          282..413
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          470..619
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          647..680
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          708..842
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          899..1027
                     /region_name="Laminin_G_2"
                     /note="Laminin G domain; pfam02210"
                     /db_xref="CDD:460494"
     Region          1091..1240
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     CDS             1..1370
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /coded_by="XM_047431964.1:1006..5118"
                     /db_xref="GeneID:9369"
                     /db_xref="HGNC:HGNC:8010"
                     /db_xref="MIM:600567"
ORIGIN      
        1 msstlhsvff tlkvsillgs llglclglef mglpnqwary lrwdastrsd lsfqfktnvs
       61 tglllylddg gvcdflclsl vdgrvqlrfs mdcaetavls nkqvndsswh flmvsrdrlr
      121 tvlmldgegq sgelqpqrpy mdvvsdlflg gvptdirpsa ltldgvqamp gfkglildlk
      181 ygnseprllg srgvqmdaeg pcgerpceng gicflldghp tcdcsttgyg gklcsedvsq
      241 dpglshlmms eqareenvat frgseylcyd lsqnpiqsss deitlsfktw qrnglilhtg
      301 ksadyvnlal kdgavslvin lgsgafeaiv epvngkfndn awhdvkvtrn lrqvtisvdg
      361 iltttgytqe dytmlgsddf fyvggspsta dlpgspvsnn fmgclkevvy knndirlels
      421 rlariadtkm kiygevvfkc envatldpin fetpeayisl pkwntkrmgs isfdfrttep
      481 nglilfthgk pqerkdarsq kntkvdffav elldgnlyll ldmgsgtikv katqkkandg
      541 ewyhvdiqrd grsgtisvns rrtpftasge seildlegdm ylgglpenra glilptelwt
      601 amlnygyvgc irdlfidgrs knirqlaemq naagvksscs rmsakqcdsy pcknnavckd
      661 gwnrficdct gtgywgrtce reasilsydg smymkiimpm vmhteaedvs frfmsqrayg
      721 llvattsrds adtlrleldg grvklmvnld cirincnssk gpetlyagqk lndnewhtvr
      781 vvrrgkslkl tvdddvaegt mvgdhtrlef hnietgimte kryisvvpss fighlqslmf
      841 ngllyidlck ngdidycelk arfglrniia dpvtfktkss ylslatlqay tsmhlffqfk
      901 ttspdgfilf nsgdgndfia velvkgyihy vfdlgngpnv ikgnsdrpln dnqwhnvvit
      961 rdnsnthslk vdtkvvtqvi ngaknldlkg dlymaglaqg mysnlpklva srdgfqgcla
     1021 svdlngrlpd lindalhrsg qiergcegps ttcqedscan qgvcmqqweg ftcdcsmtsy
     1081 sgnqcndpga tyifgksggl ilytwpandr pstrsdrlav gfsttvkdgi lvridsapgl
     1141 gdflqlhieq gkigvvfnig tvdisikeer tpvndgkyhv vrftrnggna tlqvdnwpvn
     1201 ehyptgrqlt ifntqaqiai ggkdkgrlfq gqlsglyydg lkvlnmaaen npnikingsv
     1261 rlvgevpsil gttqttsmpp emsttvmett ttmattttrk nrstasiqpt sddlvssaec
     1321 ssddedfvec epstarssna arslraaltw twrltytftp iifiscvvhs
//
LOCUS       XP_024305520            1472 aa            linear   PRI 05-AUG-2025
DEFINITION  neurexin 3 isoform X42 [Homo sapiens].
ACCESSION   XP_024305520
VERSION     XP_024305520.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449752.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1472
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1472
                     /product="neurexin 3 isoform X42"
                     /calculated_mol_wt=162559
     Region          35..181
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          202..232
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          282..421
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          478..627
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          655..688
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          716..850
                     /region_name="LamG"
                     /note="Laminin G domain; smart00282"
                     /db_xref="CDD:214598"
     Region          907..1035
                     /region_name="Laminin_G_2"
                     /note="Laminin G domain; pfam02210"
                     /db_xref="CDD:460494"
     Region          1099..1278
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          1398..1454
                     /region_name="Syndecan"
                     /note="Syndecan domain; pfam01034"
                     /db_xref="CDD:460035"
     Region          1418..1436
                     /region_name="4.1m"
                     /note="putative band 4.1 homologues' binding motif;
                     smart00294"
                     /db_xref="CDD:128590"
     CDS             1..1472
                     /gene="NRXN3"
                     /gene_synonym="C14orf60"
                     /coded_by="XM_024449752.2:1006..5424"
                     /db_xref="GeneID:9369"
                     /db_xref="HGNC:HGNC:8010"
                     /db_xref="MIM:600567"
ORIGIN      
        1 msstlhsvff tlkvsillgs llglclglef mglpnqwary lrwdastrsd lsfqfktnvs
       61 tglllylddg gvcdflclsl vdgrvqlrfs mdcaetavls nkqvndsswh flmvsrdrlr
      121 tvlmldgegq sgelqpqrpy mdvvsdlflg gvptdirpsa ltldgvqamp gfkglildlk
      181 ygnseprllg srgvqmdaeg pcgerpceng gicflldghp tcdcsttgyg gklcsedvsq
      241 dpglshlmms eqareenvat frgseylcyd lsqnpiqsss deitlsfktw qrnglilhtg
      301 ksadyvnlal kdgavslvin lgsgafeaiv epvngkfndn awhdvkvtrn lrqhsgigha
      361 mvtisvdgil tttgytqedy tmlgsddffy vggspstadl pgspvsnnfm gclkevvykn
      421 ndirlelsrl ariadtkmki ygevvfkcen vatldpinfe tpeayislpk wntkrmgsis
      481 fdfrttepng lilfthgkpq erkdarsqkn tkvdffavel ldgnlyllld mgsgtikvka
      541 tqkkandgew yhvdiqrdgr sgtisvnsrr tpftasgese ildlegdmyl gglpenragl
      601 ilptelwtam lnygyvgcir dlfidgrskn irqlaemqna agvksscsrm sakqcdsypc
      661 knnavckdgw nrficdctgt gywgrtcere asilsydgsm ymkiimpmvm hteaedvsfr
      721 fmsqraygll vattsrdsad tlrleldggr vklmvnldci rincnsskgp etlyagqkln
      781 dnewhtvrvv rrgkslkltv dddvaegtmv gdhtrlefhn ietgimtekr yisvvpssfi
      841 ghlqslmfng llyidlckng didycelkar fglrniiadp vtfktkssyl slatlqayts
      901 mhlffqfktt spdgfilfns gdgndfiave lvkgyihyvf dlgngpnvik gnsdrplndn
      961 qwhnvvitrd nsnthslkvd tkvvtqving aknldlkgdl ymaglaqgmy snlpklvasr
     1021 dgfqgclasv dlngrlpdli ndalhrsgqi ergcegpstt cqedscanqg vcmqqwegft
     1081 cdcsmtsysg nqcndpgaty ifgksgglil ytwpandrps trsdrlavgf sttvkdgilv
     1141 ridsapglgd flqlhieqgk igvvfnigtv disikeertp vndgkyhvvr ftrnggnatl
     1201 qvdnwpvneh yptgntdner fqmvkqkipf kynrpveewl qekgrqltif ntqaqiaigg
     1261 kdkgrlfqgq lsglyydglk vlnmaaennp nikingsvrl vgevpsilgt tqttsmppem
     1321 sttvmetttt mattttrknr stasiqptsd dlvssaecss ddedfvecep stanptepgi
     1381 rrvpgasevi resssttgmv vgivaaaalc ilillyamyk yrnrdegsyq vdetrnyisn
     1441 saqsngtlmk ekqqssksgh kkqknkdrey yv
//
LOCUS       XP_016877297            2320 aa            linear   PRI 05-AUG-2025
DEFINITION  A-kinase anchor protein 6 isoform X1 [Homo sapiens].
ACCESSION   XP_016877297
VERSION     XP_016877297.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021808.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2320
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2320
                     /product="A-kinase anchor protein 6 isoform X1"
                     /calculated_mol_wt=256720
     Region          784..>888
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cl02488"
                     /db_xref="CDD:413338"
     Region          962..1190
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1060..1065
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     CDS             1..2320
                     /gene="AKAP6"
                     /gene_synonym="ADAP100; ADAP6; AKAP100; mAKAP; PRKA6"
                     /coded_by="XM_017021808.3:146..7108"
                     /db_xref="GeneID:9472"
                     /db_xref="HGNC:HGNC:376"
                     /db_xref="MIM:604691"
ORIGIN      
        1 mltmsvtlsp lrsqdldpma tdaspmainm tptveqgege eamkdmdsdq qyekppplht
       61 gadwkivlhl peietwlrmt servrdltys vqqdsdskhv dvhlvqlkdi cedisdhveq
      121 ihalletefs lkllsysvnv ivdihavqll whqlrvsvlv lrerilqglq dangnytrqt
      181 dilqafseet kegrldslte vddsgqltik csqnylsldc gitafelsdy spsedllsgl
      241 gdmtssqvkt kpfdswsyse mekefpelir svglltvaad sistngseav teevsqvsls
      301 vddkggceed nasaveeqpg ltlgvssssg ealtnaaqps setvqqesss sshhdaknqq
      361 pvpcenatpk rtirdcfnyn edsptqptlp krglflkeet fkndlkgngg krqmvdlkpe
      421 msrstpslvd ppdrsklclv lqssypnsps aasqsyeclh kvgngnlent vkfhikeiss
      481 slgrlndcyk eksrlkkphk tseevppcrt pkrgtgsgkq akntkssavp ngelsytska
      541 iegpqtnsas tsslepcnqr swnaklqlqs etssspaftq ssessvgsdn imspvpllsk
      601 hkskkgqass pshvtrngev veawygsdey lalpshlkqt evlalklenl tkllpqkprg
      661 etiqniddwe lsemnsdsei yptyhvkkkh trlgrvspss ssdiasslge siesgplsdi
      721 lsdeessmpl agmkkyadek serasssekn eshsatksal iqklmqdiqh qdnyeaiwek
      781 iegfvnklde fiqwlneame ttenwtppka emddlklyle thlsfklnvd shcalkeave
      841 eeghqlleli ashkaeglkd mlrmiasqwk elqrqikrqh swilraldti kaeilatdvs
      901 vedeegtgsp kaevqlcyle aqrdaveqms lklyseqyts sskrkeefad mskvhsvgsn
      961 glldfdseyq elwdwlidme slvmdshdlm mseeqqqhly krysvemsir hlkktellsk
     1021 vealkkggvl lpndllekvd sinekwellg ktlgekiqdt maghsgsspr dllspesgsl
     1081 vrqlevrike lkgwlrdtel fifnsclrqe kegtmntekq lqyfkslcre ikqrrrgvas
     1141 ilrlcqhlld dretcnlnad hqpmqliivn lerrweaivm qavqwqtrlq kkmgkesetl
     1201 nvidpglmdl ngmsedalew demdisnkli slneesndld qelqpvipsl klgetsnedp
     1261 gydeeadnhg gsqyasnita pssphiyqvy slhnvelyed nhmpflknnp kvtgmtqpnv
     1321 ltkslskdss fsstkslpdl lggsnlvkpc achggdmsqn sgsesgivse gdtetttnse
     1381 mcllnavdgs psnletehld pqmgdavnvl kqkftdeges iklpnssqss ispvgcvngk
     1441 vgdlnsitkh tpdclgeelq gkhdvftfyd ysylqgsklk lpmimkqsqs ekahvedpll
     1501 rgfyfdkksc kskhqttelq pdvppheril asashemdri syksgniekt ftgmqnakql
     1561 sllshsssie slspggdlfg lgifkngsds lqrstslesw ltsyksnedl fschssgdis
     1621 vssgsvgels krtldllnrl eniqspseqk ikrsvsditl qsssqkmsft gqmsldiass
     1681 inedsaaslt elsssdelsl csedivlhkn kipesnasfr krltrsvade sdvnvsmivn
     1741 vsctsactdd eddsdllsss tltlteeelc ikdedddssi atddeiyedc tlmsgldyik
     1801 nelqtwirpk lsltrdkkrc nvsdemkgsk disssemtnp sdtlnietll ngsvkrvsen
     1861 ngngknssht helgtkrenk ktifkvnkdp yvadmengni egiperqkgk pnvtskvsen
     1921 lgshgkeise sehckckalm dslddsntag kefvsqdvrh lpkkcpnhhh fenqstastp
     1981 teksfselal etrfnnrqds dalkssddap smagksagcc laleqngtee nasisniscc
     2041 ncepdvfhqk daedcsvhnf vkeiidmast alksksqpen evaaptsltq ikekvlehsh
     2101 rpiqlrkgdf ysylslsshd sdcgevtnyi eeksstplpl dttdsglddk ediecffeac
     2161 vegdsdgeep cfssappnes avpseaampl qatacssefs dsslsaddad tvalsspssq
     2221 eraevgkevn glpqtssgca enleftpskl dsekessgkp gesgmpeehn aasakskvqd
     2281 lslkanqptd kaalhpspkt ltceenllnl hekrhrnmhr
//
LOCUS       XP_024305522            2320 aa            linear   PRI 05-AUG-2025
DEFINITION  A-kinase anchor protein 6 isoform X1 [Homo sapiens].
ACCESSION   XP_024305522
VERSION     XP_024305522.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449754.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2320
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2320
                     /product="A-kinase anchor protein 6 isoform X1"
                     /calculated_mol_wt=256720
     Region          784..>888
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cl02488"
                     /db_xref="CDD:413338"
     Region          962..1190
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1060..1065
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     CDS             1..2320
                     /gene="AKAP6"
                     /gene_synonym="ADAP100; ADAP6; AKAP100; mAKAP; PRKA6"
                     /coded_by="XM_024449754.2:290..7252"
                     /db_xref="GeneID:9472"
                     /db_xref="HGNC:HGNC:376"
                     /db_xref="MIM:604691"
ORIGIN      
        1 mltmsvtlsp lrsqdldpma tdaspmainm tptveqgege eamkdmdsdq qyekppplht
       61 gadwkivlhl peietwlrmt servrdltys vqqdsdskhv dvhlvqlkdi cedisdhveq
      121 ihalletefs lkllsysvnv ivdihavqll whqlrvsvlv lrerilqglq dangnytrqt
      181 dilqafseet kegrldslte vddsgqltik csqnylsldc gitafelsdy spsedllsgl
      241 gdmtssqvkt kpfdswsyse mekefpelir svglltvaad sistngseav teevsqvsls
      301 vddkggceed nasaveeqpg ltlgvssssg ealtnaaqps setvqqesss sshhdaknqq
      361 pvpcenatpk rtirdcfnyn edsptqptlp krglflkeet fkndlkgngg krqmvdlkpe
      421 msrstpslvd ppdrsklclv lqssypnsps aasqsyeclh kvgngnlent vkfhikeiss
      481 slgrlndcyk eksrlkkphk tseevppcrt pkrgtgsgkq akntkssavp ngelsytska
      541 iegpqtnsas tsslepcnqr swnaklqlqs etssspaftq ssessvgsdn imspvpllsk
      601 hkskkgqass pshvtrngev veawygsdey lalpshlkqt evlalklenl tkllpqkprg
      661 etiqniddwe lsemnsdsei yptyhvkkkh trlgrvspss ssdiasslge siesgplsdi
      721 lsdeessmpl agmkkyadek serasssekn eshsatksal iqklmqdiqh qdnyeaiwek
      781 iegfvnklde fiqwlneame ttenwtppka emddlklyle thlsfklnvd shcalkeave
      841 eeghqlleli ashkaeglkd mlrmiasqwk elqrqikrqh swilraldti kaeilatdvs
      901 vedeegtgsp kaevqlcyle aqrdaveqms lklyseqyts sskrkeefad mskvhsvgsn
      961 glldfdseyq elwdwlidme slvmdshdlm mseeqqqhly krysvemsir hlkktellsk
     1021 vealkkggvl lpndllekvd sinekwellg ktlgekiqdt maghsgsspr dllspesgsl
     1081 vrqlevrike lkgwlrdtel fifnsclrqe kegtmntekq lqyfkslcre ikqrrrgvas
     1141 ilrlcqhlld dretcnlnad hqpmqliivn lerrweaivm qavqwqtrlq kkmgkesetl
     1201 nvidpglmdl ngmsedalew demdisnkli slneesndld qelqpvipsl klgetsnedp
     1261 gydeeadnhg gsqyasnita pssphiyqvy slhnvelyed nhmpflknnp kvtgmtqpnv
     1321 ltkslskdss fsstkslpdl lggsnlvkpc achggdmsqn sgsesgivse gdtetttnse
     1381 mcllnavdgs psnletehld pqmgdavnvl kqkftdeges iklpnssqss ispvgcvngk
     1441 vgdlnsitkh tpdclgeelq gkhdvftfyd ysylqgsklk lpmimkqsqs ekahvedpll
     1501 rgfyfdkksc kskhqttelq pdvppheril asashemdri syksgniekt ftgmqnakql
     1561 sllshsssie slspggdlfg lgifkngsds lqrstslesw ltsyksnedl fschssgdis
     1621 vssgsvgels krtldllnrl eniqspseqk ikrsvsditl qsssqkmsft gqmsldiass
     1681 inedsaaslt elsssdelsl csedivlhkn kipesnasfr krltrsvade sdvnvsmivn
     1741 vsctsactdd eddsdllsss tltlteeelc ikdedddssi atddeiyedc tlmsgldyik
     1801 nelqtwirpk lsltrdkkrc nvsdemkgsk disssemtnp sdtlnietll ngsvkrvsen
     1861 ngngknssht helgtkrenk ktifkvnkdp yvadmengni egiperqkgk pnvtskvsen
     1921 lgshgkeise sehckckalm dslddsntag kefvsqdvrh lpkkcpnhhh fenqstastp
     1981 teksfselal etrfnnrqds dalkssddap smagksagcc laleqngtee nasisniscc
     2041 ncepdvfhqk daedcsvhnf vkeiidmast alksksqpen evaaptsltq ikekvlehsh
     2101 rpiqlrkgdf ysylslsshd sdcgevtnyi eeksstplpl dttdsglddk ediecffeac
     2161 vegdsdgeep cfssappnes avpseaampl qatacssefs dsslsaddad tvalsspssq
     2221 eraevgkevn glpqtssgca enleftpskl dsekessgkp gesgmpeehn aasakskvqd
     2281 lslkanqptd kaalhpspkt ltceenllnl hekrhrnmhr
//
LOCUS       XP_024305523            2320 aa            linear   PRI 05-AUG-2025
DEFINITION  A-kinase anchor protein 6 isoform X1 [Homo sapiens].
ACCESSION   XP_024305523
VERSION     XP_024305523.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449755.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2320
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2320
                     /product="A-kinase anchor protein 6 isoform X1"
                     /calculated_mol_wt=256720
     Region          784..>888
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cl02488"
                     /db_xref="CDD:413338"
     Region          962..1190
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1060..1065
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     CDS             1..2320
                     /gene="AKAP6"
                     /gene_synonym="ADAP100; ADAP6; AKAP100; mAKAP; PRKA6"
                     /coded_by="XM_024449755.2:239..7201"
                     /db_xref="GeneID:9472"
                     /db_xref="HGNC:HGNC:376"
                     /db_xref="MIM:604691"
ORIGIN      
        1 mltmsvtlsp lrsqdldpma tdaspmainm tptveqgege eamkdmdsdq qyekppplht
       61 gadwkivlhl peietwlrmt servrdltys vqqdsdskhv dvhlvqlkdi cedisdhveq
      121 ihalletefs lkllsysvnv ivdihavqll whqlrvsvlv lrerilqglq dangnytrqt
      181 dilqafseet kegrldslte vddsgqltik csqnylsldc gitafelsdy spsedllsgl
      241 gdmtssqvkt kpfdswsyse mekefpelir svglltvaad sistngseav teevsqvsls
      301 vddkggceed nasaveeqpg ltlgvssssg ealtnaaqps setvqqesss sshhdaknqq
      361 pvpcenatpk rtirdcfnyn edsptqptlp krglflkeet fkndlkgngg krqmvdlkpe
      421 msrstpslvd ppdrsklclv lqssypnsps aasqsyeclh kvgngnlent vkfhikeiss
      481 slgrlndcyk eksrlkkphk tseevppcrt pkrgtgsgkq akntkssavp ngelsytska
      541 iegpqtnsas tsslepcnqr swnaklqlqs etssspaftq ssessvgsdn imspvpllsk
      601 hkskkgqass pshvtrngev veawygsdey lalpshlkqt evlalklenl tkllpqkprg
      661 etiqniddwe lsemnsdsei yptyhvkkkh trlgrvspss ssdiasslge siesgplsdi
      721 lsdeessmpl agmkkyadek serasssekn eshsatksal iqklmqdiqh qdnyeaiwek
      781 iegfvnklde fiqwlneame ttenwtppka emddlklyle thlsfklnvd shcalkeave
      841 eeghqlleli ashkaeglkd mlrmiasqwk elqrqikrqh swilraldti kaeilatdvs
      901 vedeegtgsp kaevqlcyle aqrdaveqms lklyseqyts sskrkeefad mskvhsvgsn
      961 glldfdseyq elwdwlidme slvmdshdlm mseeqqqhly krysvemsir hlkktellsk
     1021 vealkkggvl lpndllekvd sinekwellg ktlgekiqdt maghsgsspr dllspesgsl
     1081 vrqlevrike lkgwlrdtel fifnsclrqe kegtmntekq lqyfkslcre ikqrrrgvas
     1141 ilrlcqhlld dretcnlnad hqpmqliivn lerrweaivm qavqwqtrlq kkmgkesetl
     1201 nvidpglmdl ngmsedalew demdisnkli slneesndld qelqpvipsl klgetsnedp
     1261 gydeeadnhg gsqyasnita pssphiyqvy slhnvelyed nhmpflknnp kvtgmtqpnv
     1321 ltkslskdss fsstkslpdl lggsnlvkpc achggdmsqn sgsesgivse gdtetttnse
     1381 mcllnavdgs psnletehld pqmgdavnvl kqkftdeges iklpnssqss ispvgcvngk
     1441 vgdlnsitkh tpdclgeelq gkhdvftfyd ysylqgsklk lpmimkqsqs ekahvedpll
     1501 rgfyfdkksc kskhqttelq pdvppheril asashemdri syksgniekt ftgmqnakql
     1561 sllshsssie slspggdlfg lgifkngsds lqrstslesw ltsyksnedl fschssgdis
     1621 vssgsvgels krtldllnrl eniqspseqk ikrsvsditl qsssqkmsft gqmsldiass
     1681 inedsaaslt elsssdelsl csedivlhkn kipesnasfr krltrsvade sdvnvsmivn
     1741 vsctsactdd eddsdllsss tltlteeelc ikdedddssi atddeiyedc tlmsgldyik
     1801 nelqtwirpk lsltrdkkrc nvsdemkgsk disssemtnp sdtlnietll ngsvkrvsen
     1861 ngngknssht helgtkrenk ktifkvnkdp yvadmengni egiperqkgk pnvtskvsen
     1921 lgshgkeise sehckckalm dslddsntag kefvsqdvrh lpkkcpnhhh fenqstastp
     1981 teksfselal etrfnnrqds dalkssddap smagksagcc laleqngtee nasisniscc
     2041 ncepdvfhqk daedcsvhnf vkeiidmast alksksqpen evaaptsltq ikekvlehsh
     2101 rpiqlrkgdf ysylslsshd sdcgevtnyi eeksstplpl dttdsglddk ediecffeac
     2161 vegdsdgeep cfssappnes avpseaampl qatacssefs dsslsaddad tvalsspssq
     2221 eraevgkevn glpqtssgca enleftpskl dsekessgkp gesgmpeehn aasakskvqd
     2281 lslkanqptd kaalhpspkt ltceenllnl hekrhrnmhr
//
LOCUS       XP_047287922            2320 aa            linear   PRI 05-AUG-2025
DEFINITION  A-kinase anchor protein 6 isoform X1 [Homo sapiens].
ACCESSION   XP_047287922
VERSION     XP_047287922.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431966.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2320
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2320
                     /product="A-kinase anchor protein 6 isoform X1"
                     /calculated_mol_wt=256720
     Region          784..>888
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cl02488"
                     /db_xref="CDD:413338"
     Region          962..1190
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1060..1065
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     CDS             1..2320
                     /gene="AKAP6"
                     /gene_synonym="ADAP100; ADAP6; AKAP100; mAKAP; PRKA6"
                     /coded_by="XM_047431966.1:289..7251"
                     /db_xref="GeneID:9472"
                     /db_xref="HGNC:HGNC:376"
                     /db_xref="MIM:604691"
ORIGIN      
        1 mltmsvtlsp lrsqdldpma tdaspmainm tptveqgege eamkdmdsdq qyekppplht
       61 gadwkivlhl peietwlrmt servrdltys vqqdsdskhv dvhlvqlkdi cedisdhveq
      121 ihalletefs lkllsysvnv ivdihavqll whqlrvsvlv lrerilqglq dangnytrqt
      181 dilqafseet kegrldslte vddsgqltik csqnylsldc gitafelsdy spsedllsgl
      241 gdmtssqvkt kpfdswsyse mekefpelir svglltvaad sistngseav teevsqvsls
      301 vddkggceed nasaveeqpg ltlgvssssg ealtnaaqps setvqqesss sshhdaknqq
      361 pvpcenatpk rtirdcfnyn edsptqptlp krglflkeet fkndlkgngg krqmvdlkpe
      421 msrstpslvd ppdrsklclv lqssypnsps aasqsyeclh kvgngnlent vkfhikeiss
      481 slgrlndcyk eksrlkkphk tseevppcrt pkrgtgsgkq akntkssavp ngelsytska
      541 iegpqtnsas tsslepcnqr swnaklqlqs etssspaftq ssessvgsdn imspvpllsk
      601 hkskkgqass pshvtrngev veawygsdey lalpshlkqt evlalklenl tkllpqkprg
      661 etiqniddwe lsemnsdsei yptyhvkkkh trlgrvspss ssdiasslge siesgplsdi
      721 lsdeessmpl agmkkyadek serasssekn eshsatksal iqklmqdiqh qdnyeaiwek
      781 iegfvnklde fiqwlneame ttenwtppka emddlklyle thlsfklnvd shcalkeave
      841 eeghqlleli ashkaeglkd mlrmiasqwk elqrqikrqh swilraldti kaeilatdvs
      901 vedeegtgsp kaevqlcyle aqrdaveqms lklyseqyts sskrkeefad mskvhsvgsn
      961 glldfdseyq elwdwlidme slvmdshdlm mseeqqqhly krysvemsir hlkktellsk
     1021 vealkkggvl lpndllekvd sinekwellg ktlgekiqdt maghsgsspr dllspesgsl
     1081 vrqlevrike lkgwlrdtel fifnsclrqe kegtmntekq lqyfkslcre ikqrrrgvas
     1141 ilrlcqhlld dretcnlnad hqpmqliivn lerrweaivm qavqwqtrlq kkmgkesetl
     1201 nvidpglmdl ngmsedalew demdisnkli slneesndld qelqpvipsl klgetsnedp
     1261 gydeeadnhg gsqyasnita pssphiyqvy slhnvelyed nhmpflknnp kvtgmtqpnv
     1321 ltkslskdss fsstkslpdl lggsnlvkpc achggdmsqn sgsesgivse gdtetttnse
     1381 mcllnavdgs psnletehld pqmgdavnvl kqkftdeges iklpnssqss ispvgcvngk
     1441 vgdlnsitkh tpdclgeelq gkhdvftfyd ysylqgsklk lpmimkqsqs ekahvedpll
     1501 rgfyfdkksc kskhqttelq pdvppheril asashemdri syksgniekt ftgmqnakql
     1561 sllshsssie slspggdlfg lgifkngsds lqrstslesw ltsyksnedl fschssgdis
     1621 vssgsvgels krtldllnrl eniqspseqk ikrsvsditl qsssqkmsft gqmsldiass
     1681 inedsaaslt elsssdelsl csedivlhkn kipesnasfr krltrsvade sdvnvsmivn
     1741 vsctsactdd eddsdllsss tltlteeelc ikdedddssi atddeiyedc tlmsgldyik
     1801 nelqtwirpk lsltrdkkrc nvsdemkgsk disssemtnp sdtlnietll ngsvkrvsen
     1861 ngngknssht helgtkrenk ktifkvnkdp yvadmengni egiperqkgk pnvtskvsen
     1921 lgshgkeise sehckckalm dslddsntag kefvsqdvrh lpkkcpnhhh fenqstastp
     1981 teksfselal etrfnnrqds dalkssddap smagksagcc laleqngtee nasisniscc
     2041 ncepdvfhqk daedcsvhnf vkeiidmast alksksqpen evaaptsltq ikekvlehsh
     2101 rpiqlrkgdf ysylslsshd sdcgevtnyi eeksstplpl dttdsglddk ediecffeac
     2161 vegdsdgeep cfssappnes avpseaampl qatacssefs dsslsaddad tvalsspssq
     2221 eraevgkevn glpqtssgca enleftpskl dsekessgkp gesgmpeehn aasakskvqd
     2281 lslkanqptd kaalhpspkt ltceenllnl hekrhrnmhr
//
LOCUS       XP_024305524            2320 aa            linear   PRI 05-AUG-2025
DEFINITION  A-kinase anchor protein 6 isoform X1 [Homo sapiens].
ACCESSION   XP_024305524
VERSION     XP_024305524.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449756.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2320
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2320
                     /product="A-kinase anchor protein 6 isoform X1"
                     /calculated_mol_wt=256720
     Region          784..>888
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cl02488"
                     /db_xref="CDD:413338"
     Region          962..1190
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1060..1065
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     CDS             1..2320
                     /gene="AKAP6"
                     /gene_synonym="ADAP100; ADAP6; AKAP100; mAKAP; PRKA6"
                     /coded_by="XM_024449756.2:221..7183"
                     /db_xref="GeneID:9472"
                     /db_xref="HGNC:HGNC:376"
                     /db_xref="MIM:604691"
ORIGIN      
        1 mltmsvtlsp lrsqdldpma tdaspmainm tptveqgege eamkdmdsdq qyekppplht
       61 gadwkivlhl peietwlrmt servrdltys vqqdsdskhv dvhlvqlkdi cedisdhveq
      121 ihalletefs lkllsysvnv ivdihavqll whqlrvsvlv lrerilqglq dangnytrqt
      181 dilqafseet kegrldslte vddsgqltik csqnylsldc gitafelsdy spsedllsgl
      241 gdmtssqvkt kpfdswsyse mekefpelir svglltvaad sistngseav teevsqvsls
      301 vddkggceed nasaveeqpg ltlgvssssg ealtnaaqps setvqqesss sshhdaknqq
      361 pvpcenatpk rtirdcfnyn edsptqptlp krglflkeet fkndlkgngg krqmvdlkpe
      421 msrstpslvd ppdrsklclv lqssypnsps aasqsyeclh kvgngnlent vkfhikeiss
      481 slgrlndcyk eksrlkkphk tseevppcrt pkrgtgsgkq akntkssavp ngelsytska
      541 iegpqtnsas tsslepcnqr swnaklqlqs etssspaftq ssessvgsdn imspvpllsk
      601 hkskkgqass pshvtrngev veawygsdey lalpshlkqt evlalklenl tkllpqkprg
      661 etiqniddwe lsemnsdsei yptyhvkkkh trlgrvspss ssdiasslge siesgplsdi
      721 lsdeessmpl agmkkyadek serasssekn eshsatksal iqklmqdiqh qdnyeaiwek
      781 iegfvnklde fiqwlneame ttenwtppka emddlklyle thlsfklnvd shcalkeave
      841 eeghqlleli ashkaeglkd mlrmiasqwk elqrqikrqh swilraldti kaeilatdvs
      901 vedeegtgsp kaevqlcyle aqrdaveqms lklyseqyts sskrkeefad mskvhsvgsn
      961 glldfdseyq elwdwlidme slvmdshdlm mseeqqqhly krysvemsir hlkktellsk
     1021 vealkkggvl lpndllekvd sinekwellg ktlgekiqdt maghsgsspr dllspesgsl
     1081 vrqlevrike lkgwlrdtel fifnsclrqe kegtmntekq lqyfkslcre ikqrrrgvas
     1141 ilrlcqhlld dretcnlnad hqpmqliivn lerrweaivm qavqwqtrlq kkmgkesetl
     1201 nvidpglmdl ngmsedalew demdisnkli slneesndld qelqpvipsl klgetsnedp
     1261 gydeeadnhg gsqyasnita pssphiyqvy slhnvelyed nhmpflknnp kvtgmtqpnv
     1321 ltkslskdss fsstkslpdl lggsnlvkpc achggdmsqn sgsesgivse gdtetttnse
     1381 mcllnavdgs psnletehld pqmgdavnvl kqkftdeges iklpnssqss ispvgcvngk
     1441 vgdlnsitkh tpdclgeelq gkhdvftfyd ysylqgsklk lpmimkqsqs ekahvedpll
     1501 rgfyfdkksc kskhqttelq pdvppheril asashemdri syksgniekt ftgmqnakql
     1561 sllshsssie slspggdlfg lgifkngsds lqrstslesw ltsyksnedl fschssgdis
     1621 vssgsvgels krtldllnrl eniqspseqk ikrsvsditl qsssqkmsft gqmsldiass
     1681 inedsaaslt elsssdelsl csedivlhkn kipesnasfr krltrsvade sdvnvsmivn
     1741 vsctsactdd eddsdllsss tltlteeelc ikdedddssi atddeiyedc tlmsgldyik
     1801 nelqtwirpk lsltrdkkrc nvsdemkgsk disssemtnp sdtlnietll ngsvkrvsen
     1861 ngngknssht helgtkrenk ktifkvnkdp yvadmengni egiperqkgk pnvtskvsen
     1921 lgshgkeise sehckckalm dslddsntag kefvsqdvrh lpkkcpnhhh fenqstastp
     1981 teksfselal etrfnnrqds dalkssddap smagksagcc laleqngtee nasisniscc
     2041 ncepdvfhqk daedcsvhnf vkeiidmast alksksqpen evaaptsltq ikekvlehsh
     2101 rpiqlrkgdf ysylslsshd sdcgevtnyi eeksstplpl dttdsglddk ediecffeac
     2161 vegdsdgeep cfssappnes avpseaampl qatacssefs dsslsaddad tvalsspssq
     2221 eraevgkevn glpqtssgca enleftpskl dsekessgkp gesgmpeehn aasakskvqd
     2281 lslkanqptd kaalhpspkt ltceenllnl hekrhrnmhr
//
LOCUS       XP_024305525            2320 aa            linear   PRI 05-AUG-2025
DEFINITION  A-kinase anchor protein 6 isoform X1 [Homo sapiens].
ACCESSION   XP_024305525
VERSION     XP_024305525.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449757.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2320
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2320
                     /product="A-kinase anchor protein 6 isoform X1"
                     /calculated_mol_wt=256720
     Region          784..>888
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cl02488"
                     /db_xref="CDD:413338"
     Region          962..1190
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1060..1065
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     CDS             1..2320
                     /gene="AKAP6"
                     /gene_synonym="ADAP100; ADAP6; AKAP100; mAKAP; PRKA6"
                     /coded_by="XM_024449757.2:104..7066"
                     /db_xref="GeneID:9472"
                     /db_xref="HGNC:HGNC:376"
                     /db_xref="MIM:604691"
ORIGIN      
        1 mltmsvtlsp lrsqdldpma tdaspmainm tptveqgege eamkdmdsdq qyekppplht
       61 gadwkivlhl peietwlrmt servrdltys vqqdsdskhv dvhlvqlkdi cedisdhveq
      121 ihalletefs lkllsysvnv ivdihavqll whqlrvsvlv lrerilqglq dangnytrqt
      181 dilqafseet kegrldslte vddsgqltik csqnylsldc gitafelsdy spsedllsgl
      241 gdmtssqvkt kpfdswsyse mekefpelir svglltvaad sistngseav teevsqvsls
      301 vddkggceed nasaveeqpg ltlgvssssg ealtnaaqps setvqqesss sshhdaknqq
      361 pvpcenatpk rtirdcfnyn edsptqptlp krglflkeet fkndlkgngg krqmvdlkpe
      421 msrstpslvd ppdrsklclv lqssypnsps aasqsyeclh kvgngnlent vkfhikeiss
      481 slgrlndcyk eksrlkkphk tseevppcrt pkrgtgsgkq akntkssavp ngelsytska
      541 iegpqtnsas tsslepcnqr swnaklqlqs etssspaftq ssessvgsdn imspvpllsk
      601 hkskkgqass pshvtrngev veawygsdey lalpshlkqt evlalklenl tkllpqkprg
      661 etiqniddwe lsemnsdsei yptyhvkkkh trlgrvspss ssdiasslge siesgplsdi
      721 lsdeessmpl agmkkyadek serasssekn eshsatksal iqklmqdiqh qdnyeaiwek
      781 iegfvnklde fiqwlneame ttenwtppka emddlklyle thlsfklnvd shcalkeave
      841 eeghqlleli ashkaeglkd mlrmiasqwk elqrqikrqh swilraldti kaeilatdvs
      901 vedeegtgsp kaevqlcyle aqrdaveqms lklyseqyts sskrkeefad mskvhsvgsn
      961 glldfdseyq elwdwlidme slvmdshdlm mseeqqqhly krysvemsir hlkktellsk
     1021 vealkkggvl lpndllekvd sinekwellg ktlgekiqdt maghsgsspr dllspesgsl
     1081 vrqlevrike lkgwlrdtel fifnsclrqe kegtmntekq lqyfkslcre ikqrrrgvas
     1141 ilrlcqhlld dretcnlnad hqpmqliivn lerrweaivm qavqwqtrlq kkmgkesetl
     1201 nvidpglmdl ngmsedalew demdisnkli slneesndld qelqpvipsl klgetsnedp
     1261 gydeeadnhg gsqyasnita pssphiyqvy slhnvelyed nhmpflknnp kvtgmtqpnv
     1321 ltkslskdss fsstkslpdl lggsnlvkpc achggdmsqn sgsesgivse gdtetttnse
     1381 mcllnavdgs psnletehld pqmgdavnvl kqkftdeges iklpnssqss ispvgcvngk
     1441 vgdlnsitkh tpdclgeelq gkhdvftfyd ysylqgsklk lpmimkqsqs ekahvedpll
     1501 rgfyfdkksc kskhqttelq pdvppheril asashemdri syksgniekt ftgmqnakql
     1561 sllshsssie slspggdlfg lgifkngsds lqrstslesw ltsyksnedl fschssgdis
     1621 vssgsvgels krtldllnrl eniqspseqk ikrsvsditl qsssqkmsft gqmsldiass
     1681 inedsaaslt elsssdelsl csedivlhkn kipesnasfr krltrsvade sdvnvsmivn
     1741 vsctsactdd eddsdllsss tltlteeelc ikdedddssi atddeiyedc tlmsgldyik
     1801 nelqtwirpk lsltrdkkrc nvsdemkgsk disssemtnp sdtlnietll ngsvkrvsen
     1861 ngngknssht helgtkrenk ktifkvnkdp yvadmengni egiperqkgk pnvtskvsen
     1921 lgshgkeise sehckckalm dslddsntag kefvsqdvrh lpkkcpnhhh fenqstastp
     1981 teksfselal etrfnnrqds dalkssddap smagksagcc laleqngtee nasisniscc
     2041 ncepdvfhqk daedcsvhnf vkeiidmast alksksqpen evaaptsltq ikekvlehsh
     2101 rpiqlrkgdf ysylslsshd sdcgevtnyi eeksstplpl dttdsglddk ediecffeac
     2161 vegdsdgeep cfssappnes avpseaampl qatacssefs dsslsaddad tvalsspssq
     2221 eraevgkevn glpqtssgca enleftpskl dsekessgkp gesgmpeehn aasakskvqd
     2281 lslkanqptd kaalhpspkt ltceenllnl hekrhrnmhr
//
LOCUS       XP_047287923            2319 aa            linear   PRI 05-AUG-2025
DEFINITION  A-kinase anchor protein 6 isoform X2 [Homo sapiens].
ACCESSION   XP_047287923
VERSION     XP_047287923.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431967.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2319
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2319
                     /product="A-kinase anchor protein 6 isoform X2"
                     /calculated_mol_wt=256590
     Region          784..>887
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cl02488"
                     /db_xref="CDD:413338"
     Region          961..1189
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1059..1064
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     CDS             1..2319
                     /gene="AKAP6"
                     /gene_synonym="ADAP100; ADAP6; AKAP100; mAKAP; PRKA6"
                     /coded_by="XM_047431967.1:290..7249"
                     /db_xref="GeneID:9472"
                     /db_xref="HGNC:HGNC:376"
                     /db_xref="MIM:604691"
ORIGIN      
        1 mltmsvtlsp lrsqdldpma tdaspmainm tptveqgege eamkdmdsdq qyekppplht
       61 gadwkivlhl peietwlrmt servrdltys vqqdsdskhv dvhlvqlkdi cedisdhveq
      121 ihalletefs lkllsysvnv ivdihavqll whqlrvsvlv lrerilqglq dangnytrqt
      181 dilqafseet kegrldslte vddsgqltik csqnylsldc gitafelsdy spsedllsgl
      241 gdmtssqvkt kpfdswsyse mekefpelir svglltvaad sistngseav teevsqvsls
      301 vddkggceed nasaveeqpg ltlgvssssg ealtnaaqps setvqqesss sshhdaknqq
      361 pvpcenatpk rtirdcfnyn edsptqptlp krglflkeet fkndlkgngg krqmvdlkpe
      421 msrstpslvd ppdrsklclv lqssypnsps aasqsyeclh kvgngnlent vkfhikeiss
      481 slgrlndcyk eksrlkkphk tseevppcrt pkrgtgsgkq akntkssavp ngelsytska
      541 iegpqtnsas tsslepcnqr swnaklqlqs etssspaftq ssessvgsdn imspvpllsk
      601 hkskkgqass pshvtrngev veawygsdey lalpshlkqt evlalklenl tkllpqkprg
      661 etiqniddwe lsemnsdsei yptyhvkkkh trlgrvspss ssdiasslge siesgplsdi
      721 lsdeessmpl agmkkyadek serasssekn eshsatksal iqklmqdiqh qdnyeaiwek
      781 iegfvnklde fiqwlneame ttenwtppka emddlklyle thlsfklnvd shcalkeave
      841 eeghqlleli ashkaglkdm lrmiasqwke lqrqikrqhs wilraldtik aeilatdvsv
      901 edeegtgspk aevqlcylea qrdaveqmsl klyseqytss skrkeefadm skvhsvgsng
      961 lldfdseyqe lwdwlidmes lvmdshdlmm seeqqqhlyk rysvemsirh lkktellskv
     1021 ealkkggvll pndllekvds inekwellgk tlgekiqdtm aghsgssprd llspesgslv
     1081 rqlevrikel kgwlrdtelf ifnsclrqek egtmntekql qyfkslcrei kqrrrgvasi
     1141 lrlcqhlldd retcnlnadh qpmqliivnl errweaivmq avqwqtrlqk kmgkesetln
     1201 vidpglmdln gmsedalewd emdisnklis lneesndldq elqpvipslk lgetsnedpg
     1261 ydeeadnhgg sqyasnitap ssphiyqvys lhnvelyedn hmpflknnpk vtgmtqpnvl
     1321 tkslskdssf sstkslpdll ggsnlvkpca chggdmsqns gsesgivseg dtetttnsem
     1381 cllnavdgsp snletehldp qmgdavnvlk qkftdegesi klpnssqssi spvgcvngkv
     1441 gdlnsitkht pdclgeelqg khdvftfydy sylqgsklkl pmimkqsqse kahvedpllr
     1501 gfyfdkksck skhqttelqp dvppherila sashemdris yksgniektf tgmqnakqls
     1561 llshsssies lspggdlfgl gifkngsdsl qrstsleswl tsyksnedlf schssgdisv
     1621 ssgsvgelsk rtldllnrle niqspseqki krsvsditlq sssqkmsftg qmsldiassi
     1681 nedsaaslte lsssdelslc sedivlhknk ipesnasfrk rltrsvades dvnvsmivnv
     1741 sctsactdde ddsdllssst ltlteeelci kdedddssia tddeiyedct lmsgldyikn
     1801 elqtwirpkl sltrdkkrcn vsdemkgskd isssemtnps dtlnietlln gsvkrvsenn
     1861 gngknsshth elgtkrenkk tifkvnkdpy vadmengnie giperqkgkp nvtskvsenl
     1921 gshgkeises ehckckalmd slddsntagk efvsqdvrhl pkkcpnhhhf enqstastpt
     1981 eksfselale trfnnrqdsd alkssddaps magksagccl aleqngteen asisnisccn
     2041 cepdvfhqkd aedcsvhnfv keiidmasta lksksqpene vaaptsltqi kekvlehshr
     2101 piqlrkgdfy sylslsshds dcgevtnyie eksstplpld ttdsglddke diecffeacv
     2161 egdsdgeepc fssappnesa vpseaamplq atacssefsd sslsaddadt valsspssqe
     2221 raevgkevng lpqtssgcae nleftpskld sekessgkpg esgmpeehna asakskvqdl
     2281 slkanqptdk aalhpspktl tceenllnlh ekrhrnmhr
//
LOCUS       XP_047287924            2319 aa            linear   PRI 05-AUG-2025
DEFINITION  A-kinase anchor protein 6 isoform X2 [Homo sapiens].
ACCESSION   XP_047287924
VERSION     XP_047287924.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431968.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2319
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2319
                     /product="A-kinase anchor protein 6 isoform X2"
                     /calculated_mol_wt=256590
     Region          784..>887
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cl02488"
                     /db_xref="CDD:413338"
     Region          961..1189
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1059..1064
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     CDS             1..2319
                     /gene="AKAP6"
                     /gene_synonym="ADAP100; ADAP6; AKAP100; mAKAP; PRKA6"
                     /coded_by="XM_047431968.1:104..7063"
                     /db_xref="GeneID:9472"
                     /db_xref="HGNC:HGNC:376"
                     /db_xref="MIM:604691"
ORIGIN      
        1 mltmsvtlsp lrsqdldpma tdaspmainm tptveqgege eamkdmdsdq qyekppplht
       61 gadwkivlhl peietwlrmt servrdltys vqqdsdskhv dvhlvqlkdi cedisdhveq
      121 ihalletefs lkllsysvnv ivdihavqll whqlrvsvlv lrerilqglq dangnytrqt
      181 dilqafseet kegrldslte vddsgqltik csqnylsldc gitafelsdy spsedllsgl
      241 gdmtssqvkt kpfdswsyse mekefpelir svglltvaad sistngseav teevsqvsls
      301 vddkggceed nasaveeqpg ltlgvssssg ealtnaaqps setvqqesss sshhdaknqq
      361 pvpcenatpk rtirdcfnyn edsptqptlp krglflkeet fkndlkgngg krqmvdlkpe
      421 msrstpslvd ppdrsklclv lqssypnsps aasqsyeclh kvgngnlent vkfhikeiss
      481 slgrlndcyk eksrlkkphk tseevppcrt pkrgtgsgkq akntkssavp ngelsytska
      541 iegpqtnsas tsslepcnqr swnaklqlqs etssspaftq ssessvgsdn imspvpllsk
      601 hkskkgqass pshvtrngev veawygsdey lalpshlkqt evlalklenl tkllpqkprg
      661 etiqniddwe lsemnsdsei yptyhvkkkh trlgrvspss ssdiasslge siesgplsdi
      721 lsdeessmpl agmkkyadek serasssekn eshsatksal iqklmqdiqh qdnyeaiwek
      781 iegfvnklde fiqwlneame ttenwtppka emddlklyle thlsfklnvd shcalkeave
      841 eeghqlleli ashkaglkdm lrmiasqwke lqrqikrqhs wilraldtik aeilatdvsv
      901 edeegtgspk aevqlcylea qrdaveqmsl klyseqytss skrkeefadm skvhsvgsng
      961 lldfdseyqe lwdwlidmes lvmdshdlmm seeqqqhlyk rysvemsirh lkktellskv
     1021 ealkkggvll pndllekvds inekwellgk tlgekiqdtm aghsgssprd llspesgslv
     1081 rqlevrikel kgwlrdtelf ifnsclrqek egtmntekql qyfkslcrei kqrrrgvasi
     1141 lrlcqhlldd retcnlnadh qpmqliivnl errweaivmq avqwqtrlqk kmgkesetln
     1201 vidpglmdln gmsedalewd emdisnklis lneesndldq elqpvipslk lgetsnedpg
     1261 ydeeadnhgg sqyasnitap ssphiyqvys lhnvelyedn hmpflknnpk vtgmtqpnvl
     1321 tkslskdssf sstkslpdll ggsnlvkpca chggdmsqns gsesgivseg dtetttnsem
     1381 cllnavdgsp snletehldp qmgdavnvlk qkftdegesi klpnssqssi spvgcvngkv
     1441 gdlnsitkht pdclgeelqg khdvftfydy sylqgsklkl pmimkqsqse kahvedpllr
     1501 gfyfdkksck skhqttelqp dvppherila sashemdris yksgniektf tgmqnakqls
     1561 llshsssies lspggdlfgl gifkngsdsl qrstsleswl tsyksnedlf schssgdisv
     1621 ssgsvgelsk rtldllnrle niqspseqki krsvsditlq sssqkmsftg qmsldiassi
     1681 nedsaaslte lsssdelslc sedivlhknk ipesnasfrk rltrsvades dvnvsmivnv
     1741 sctsactdde ddsdllssst ltlteeelci kdedddssia tddeiyedct lmsgldyikn
     1801 elqtwirpkl sltrdkkrcn vsdemkgskd isssemtnps dtlnietlln gsvkrvsenn
     1861 gngknsshth elgtkrenkk tifkvnkdpy vadmengnie giperqkgkp nvtskvsenl
     1921 gshgkeises ehckckalmd slddsntagk efvsqdvrhl pkkcpnhhhf enqstastpt
     1981 eksfselale trfnnrqdsd alkssddaps magksagccl aleqngteen asisnisccn
     2041 cepdvfhqkd aedcsvhnfv keiidmasta lksksqpene vaaptsltqi kekvlehshr
     2101 piqlrkgdfy sylslsshds dcgevtnyie eksstplpld ttdsglddke diecffeacv
     2161 egdsdgeepc fssappnesa vpseaamplq atacssefsd sslsaddadt valsspssqe
     2221 raevgkevng lpqtssgcae nleftpskld sekessgkpg esgmpeehna asakskvqdl
     2281 slkanqptdk aalhpspktl tceenllnlh ekrhrnmhr
//
LOCUS       XP_047287925            2319 aa            linear   PRI 05-AUG-2025
DEFINITION  A-kinase anchor protein 6 isoform X2 [Homo sapiens].
ACCESSION   XP_047287925
VERSION     XP_047287925.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431969.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2319
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2319
                     /product="A-kinase anchor protein 6 isoform X2"
                     /calculated_mol_wt=256590
     Region          784..>887
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cl02488"
                     /db_xref="CDD:413338"
     Region          961..1189
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1059..1064
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     CDS             1..2319
                     /gene="AKAP6"
                     /gene_synonym="ADAP100; ADAP6; AKAP100; mAKAP; PRKA6"
                     /coded_by="XM_047431969.1:358..7317"
                     /db_xref="GeneID:9472"
                     /db_xref="HGNC:HGNC:376"
                     /db_xref="MIM:604691"
ORIGIN      
        1 mltmsvtlsp lrsqdldpma tdaspmainm tptveqgege eamkdmdsdq qyekppplht
       61 gadwkivlhl peietwlrmt servrdltys vqqdsdskhv dvhlvqlkdi cedisdhveq
      121 ihalletefs lkllsysvnv ivdihavqll whqlrvsvlv lrerilqglq dangnytrqt
      181 dilqafseet kegrldslte vddsgqltik csqnylsldc gitafelsdy spsedllsgl
      241 gdmtssqvkt kpfdswsyse mekefpelir svglltvaad sistngseav teevsqvsls
      301 vddkggceed nasaveeqpg ltlgvssssg ealtnaaqps setvqqesss sshhdaknqq
      361 pvpcenatpk rtirdcfnyn edsptqptlp krglflkeet fkndlkgngg krqmvdlkpe
      421 msrstpslvd ppdrsklclv lqssypnsps aasqsyeclh kvgngnlent vkfhikeiss
      481 slgrlndcyk eksrlkkphk tseevppcrt pkrgtgsgkq akntkssavp ngelsytska
      541 iegpqtnsas tsslepcnqr swnaklqlqs etssspaftq ssessvgsdn imspvpllsk
      601 hkskkgqass pshvtrngev veawygsdey lalpshlkqt evlalklenl tkllpqkprg
      661 etiqniddwe lsemnsdsei yptyhvkkkh trlgrvspss ssdiasslge siesgplsdi
      721 lsdeessmpl agmkkyadek serasssekn eshsatksal iqklmqdiqh qdnyeaiwek
      781 iegfvnklde fiqwlneame ttenwtppka emddlklyle thlsfklnvd shcalkeave
      841 eeghqlleli ashkaglkdm lrmiasqwke lqrqikrqhs wilraldtik aeilatdvsv
      901 edeegtgspk aevqlcylea qrdaveqmsl klyseqytss skrkeefadm skvhsvgsng
      961 lldfdseyqe lwdwlidmes lvmdshdlmm seeqqqhlyk rysvemsirh lkktellskv
     1021 ealkkggvll pndllekvds inekwellgk tlgekiqdtm aghsgssprd llspesgslv
     1081 rqlevrikel kgwlrdtelf ifnsclrqek egtmntekql qyfkslcrei kqrrrgvasi
     1141 lrlcqhlldd retcnlnadh qpmqliivnl errweaivmq avqwqtrlqk kmgkesetln
     1201 vidpglmdln gmsedalewd emdisnklis lneesndldq elqpvipslk lgetsnedpg
     1261 ydeeadnhgg sqyasnitap ssphiyqvys lhnvelyedn hmpflknnpk vtgmtqpnvl
     1321 tkslskdssf sstkslpdll ggsnlvkpca chggdmsqns gsesgivseg dtetttnsem
     1381 cllnavdgsp snletehldp qmgdavnvlk qkftdegesi klpnssqssi spvgcvngkv
     1441 gdlnsitkht pdclgeelqg khdvftfydy sylqgsklkl pmimkqsqse kahvedpllr
     1501 gfyfdkksck skhqttelqp dvppherila sashemdris yksgniektf tgmqnakqls
     1561 llshsssies lspggdlfgl gifkngsdsl qrstsleswl tsyksnedlf schssgdisv
     1621 ssgsvgelsk rtldllnrle niqspseqki krsvsditlq sssqkmsftg qmsldiassi
     1681 nedsaaslte lsssdelslc sedivlhknk ipesnasfrk rltrsvades dvnvsmivnv
     1741 sctsactdde ddsdllssst ltlteeelci kdedddssia tddeiyedct lmsgldyikn
     1801 elqtwirpkl sltrdkkrcn vsdemkgskd isssemtnps dtlnietlln gsvkrvsenn
     1861 gngknsshth elgtkrenkk tifkvnkdpy vadmengnie giperqkgkp nvtskvsenl
     1921 gshgkeises ehckckalmd slddsntagk efvsqdvrhl pkkcpnhhhf enqstastpt
     1981 eksfselale trfnnrqdsd alkssddaps magksagccl aleqngteen asisnisccn
     2041 cepdvfhqkd aedcsvhnfv keiidmasta lksksqpene vaaptsltqi kekvlehshr
     2101 piqlrkgdfy sylslsshds dcgevtnyie eksstplpld ttdsglddke diecffeacv
     2161 egdsdgeepc fssappnesa vpseaamplq atacssefsd sslsaddadt valsspssqe
     2221 raevgkevng lpqtssgcae nleftpskld sekessgkpg esgmpeehna asakskvqdl
     2281 slkanqptdk aalhpspktl tceenllnlh ekrhrnmhr
//
LOCUS       XP_047287926            2319 aa            linear   PRI 05-AUG-2025
DEFINITION  A-kinase anchor protein 6 isoform X2 [Homo sapiens].
ACCESSION   XP_047287926
VERSION     XP_047287926.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431970.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2319
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2319
                     /product="A-kinase anchor protein 6 isoform X2"
                     /calculated_mol_wt=256590
     Region          784..>887
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cl02488"
                     /db_xref="CDD:413338"
     Region          961..1189
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1059..1064
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     CDS             1..2319
                     /gene="AKAP6"
                     /gene_synonym="ADAP100; ADAP6; AKAP100; mAKAP; PRKA6"
                     /coded_by="XM_047431970.1:239..7198"
                     /db_xref="GeneID:9472"
                     /db_xref="HGNC:HGNC:376"
                     /db_xref="MIM:604691"
ORIGIN      
        1 mltmsvtlsp lrsqdldpma tdaspmainm tptveqgege eamkdmdsdq qyekppplht
       61 gadwkivlhl peietwlrmt servrdltys vqqdsdskhv dvhlvqlkdi cedisdhveq
      121 ihalletefs lkllsysvnv ivdihavqll whqlrvsvlv lrerilqglq dangnytrqt
      181 dilqafseet kegrldslte vddsgqltik csqnylsldc gitafelsdy spsedllsgl
      241 gdmtssqvkt kpfdswsyse mekefpelir svglltvaad sistngseav teevsqvsls
      301 vddkggceed nasaveeqpg ltlgvssssg ealtnaaqps setvqqesss sshhdaknqq
      361 pvpcenatpk rtirdcfnyn edsptqptlp krglflkeet fkndlkgngg krqmvdlkpe
      421 msrstpslvd ppdrsklclv lqssypnsps aasqsyeclh kvgngnlent vkfhikeiss
      481 slgrlndcyk eksrlkkphk tseevppcrt pkrgtgsgkq akntkssavp ngelsytska
      541 iegpqtnsas tsslepcnqr swnaklqlqs etssspaftq ssessvgsdn imspvpllsk
      601 hkskkgqass pshvtrngev veawygsdey lalpshlkqt evlalklenl tkllpqkprg
      661 etiqniddwe lsemnsdsei yptyhvkkkh trlgrvspss ssdiasslge siesgplsdi
      721 lsdeessmpl agmkkyadek serasssekn eshsatksal iqklmqdiqh qdnyeaiwek
      781 iegfvnklde fiqwlneame ttenwtppka emddlklyle thlsfklnvd shcalkeave
      841 eeghqlleli ashkaglkdm lrmiasqwke lqrqikrqhs wilraldtik aeilatdvsv
      901 edeegtgspk aevqlcylea qrdaveqmsl klyseqytss skrkeefadm skvhsvgsng
      961 lldfdseyqe lwdwlidmes lvmdshdlmm seeqqqhlyk rysvemsirh lkktellskv
     1021 ealkkggvll pndllekvds inekwellgk tlgekiqdtm aghsgssprd llspesgslv
     1081 rqlevrikel kgwlrdtelf ifnsclrqek egtmntekql qyfkslcrei kqrrrgvasi
     1141 lrlcqhlldd retcnlnadh qpmqliivnl errweaivmq avqwqtrlqk kmgkesetln
     1201 vidpglmdln gmsedalewd emdisnklis lneesndldq elqpvipslk lgetsnedpg
     1261 ydeeadnhgg sqyasnitap ssphiyqvys lhnvelyedn hmpflknnpk vtgmtqpnvl
     1321 tkslskdssf sstkslpdll ggsnlvkpca chggdmsqns gsesgivseg dtetttnsem
     1381 cllnavdgsp snletehldp qmgdavnvlk qkftdegesi klpnssqssi spvgcvngkv
     1441 gdlnsitkht pdclgeelqg khdvftfydy sylqgsklkl pmimkqsqse kahvedpllr
     1501 gfyfdkksck skhqttelqp dvppherila sashemdris yksgniektf tgmqnakqls
     1561 llshsssies lspggdlfgl gifkngsdsl qrstsleswl tsyksnedlf schssgdisv
     1621 ssgsvgelsk rtldllnrle niqspseqki krsvsditlq sssqkmsftg qmsldiassi
     1681 nedsaaslte lsssdelslc sedivlhknk ipesnasfrk rltrsvades dvnvsmivnv
     1741 sctsactdde ddsdllssst ltlteeelci kdedddssia tddeiyedct lmsgldyikn
     1801 elqtwirpkl sltrdkkrcn vsdemkgskd isssemtnps dtlnietlln gsvkrvsenn
     1861 gngknsshth elgtkrenkk tifkvnkdpy vadmengnie giperqkgkp nvtskvsenl
     1921 gshgkeises ehckckalmd slddsntagk efvsqdvrhl pkkcpnhhhf enqstastpt
     1981 eksfselale trfnnrqdsd alkssddaps magksagccl aleqngteen asisnisccn
     2041 cepdvfhqkd aedcsvhnfv keiidmasta lksksqpene vaaptsltqi kekvlehshr
     2101 piqlrkgdfy sylslsshds dcgevtnyie eksstplpld ttdsglddke diecffeacv
     2161 egdsdgeepc fssappnesa vpseaamplq atacssefsd sslsaddadt valsspssqe
     2221 raevgkevng lpqtssgcae nleftpskld sekessgkpg esgmpeehna asakskvqdl
     2281 slkanqptdk aalhpspktl tceenllnlh ekrhrnmhr
//
LOCUS       XP_047287927            2078 aa            linear   PRI 05-AUG-2025
DEFINITION  A-kinase anchor protein 6 isoform X3 [Homo sapiens].
ACCESSION   XP_047287927
VERSION     XP_047287927.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431971.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2078
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..2078
                     /product="A-kinase anchor protein 6 isoform X3"
                     /calculated_mol_wt=229464
     Region          542..>646
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cl02488"
                     /db_xref="CDD:413338"
     Region          720..948
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            818..823
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     CDS             1..2078
                     /gene="AKAP6"
                     /gene_synonym="ADAP100; ADAP6; AKAP100; mAKAP; PRKA6"
                     /coded_by="XM_047431971.1:881..7117"
                     /db_xref="GeneID:9472"
                     /db_xref="HGNC:HGNC:376"
                     /db_xref="MIM:604691"
ORIGIN      
        1 mtssqvktkp fdswsyseme kefpelirsv glltvaadsi stngseavte evsqvslsvd
       61 dkggceedna saveeqpglt lgvssssgea ltnaaqpsse tvqqesssss hhdaknqqpv
      121 pcenatpkrt irdcfnyned sptqptlpkr glflkeetfk ndlkgnggkr qmvdlkpems
      181 rstpslvdpp drsklclvlq ssypnspsaa sqsyeclhkv gngnlentvk fhikeisssl
      241 grlndcykek srlkkphkts eevppcrtpk rgtgsgkqak ntkssavpng elsytskaie
      301 gpqtnsasts slepcnqrsw naklqlqset ssspaftqss essvgsdnim spvpllskhk
      361 skkgqassps hvtrngevve awygsdeyla lpshlkqtev lalklenltk llpqkprget
      421 iqniddwels emnsdseiyp tyhvkkkhtr lgrvspssss diasslgesi esgplsdils
      481 deessmplag mkkyadekse rassseknes hsatksaliq klmqdiqhqd nyeaiwekie
      541 gfvnkldefi qwlneamett enwtppkaem ddlklyleth lsfklnvdsh calkeaveee
      601 ghqllelias hkaeglkdml rmiasqwkel qrqikrqhsw ilraldtika eilatdvsve
      661 deegtgspka evqlcyleaq rdaveqmslk lyseqytsss krkeefadms kvhsvgsngl
      721 ldfdseyqel wdwlidmesl vmdshdlmms eeqqqhlykr ysvemsirhl kktellskve
      781 alkkggvllp ndllekvdsi nekwellgkt lgekiqdtma ghsgssprdl lspesgslvr
      841 qlevrikelk gwlrdtelfi fnsclrqeke gtmntekqlq yfkslcreik qrrrgvasil
      901 rlcqhllddr etcnlnadhq pmqliivnle rrweaivmqa vqwqtrlqkk mgkesetlnv
      961 idpglmdlng msedalewde mdisnklisl neesndldqe lqpvipslkl getsnedpgy
     1021 deeadnhggs qyasnitaps sphiyqvysl hnvelyednh mpflknnpkv tgmtqpnvlt
     1081 kslskdssfs stkslpdllg gsnlvkpcac hggdmsqnsg sesgivsegd tetttnsemc
     1141 llnavdgsps nletehldpq mgdavnvlkq kftdegesik lpnssqssis pvgcvngkvg
     1201 dlnsitkhtp dclgeelqgk hdvftfydys ylqgsklklp mimkqsqsek ahvedpllrg
     1261 fyfdkkscks khqttelqpd vppherilas ashemdrisy ksgniektft gmqnakqlsl
     1321 lshsssiesl spggdlfglg ifkngsdslq rstsleswlt syksnedlfs chssgdisvs
     1381 sgsvgelskr tldllnrlen iqspseqkik rsvsditlqs ssqkmsftgq msldiassin
     1441 edsaasltel sssdelslcs edivlhknki pesnasfrkr ltrsvadesd vnvsmivnvs
     1501 ctsactdded dsdllssstl tlteeelcik dedddssiat ddeiyedctl msgldyikne
     1561 lqtwirpkls ltrdkkrcnv sdemkgskdi sssemtnpsd tlnietllng svkrvsenng
     1621 ngknsshthe lgtkrenkkt ifkvnkdpyv admengnieg iperqkgkpn vtskvsenlg
     1681 shgkeisese hckckalmds lddsntagke fvsqdvrhlp kkcpnhhhfe nqstastpte
     1741 ksfselalet rfnnrqdsda lkssddapsm agksagccla leqngteena sisnisccnc
     1801 epdvfhqkda edcsvhnfvk eiidmastal ksksqpenev aaptsltqik ekvlehshrp
     1861 iqlrkgdfys ylslsshdsd cgevtnyiee ksstplpldt tdsglddked iecffeacve
     1921 gdsdgeepcf ssappnesav pseaamplqa tacssefsds slsaddadtv alsspssqer
     1981 aevgkevngl pqtssgcaen leftpsklds ekessgkpge sgmpeehnaa sakskvqdls
     2041 lkanqptdka alhpspktlt ceenllnlhe krhrnmhr
//
LOCUS       XP_011535680            1415 aa            linear   PRI 05-AUG-2025
DEFINITION  A-kinase anchor protein 6 isoform X4 [Homo sapiens].
ACCESSION   XP_011535680
VERSION     XP_011535680.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537378.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1415
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1415
                     /product="A-kinase anchor protein 6 isoform X4"
                     /calculated_mol_wt=156389
     Region          57..285
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            155..160
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     CDS             1..1415
                     /gene="AKAP6"
                     /gene_synonym="ADAP100; ADAP6; AKAP100; mAKAP; PRKA6"
                     /coded_by="XM_011537378.4:106..4353"
                     /db_xref="GeneID:9472"
                     /db_xref="HGNC:HGNC:376"
                     /db_xref="MIM:604691"
ORIGIN      
        1 meitevaevq lcyleaqrda veqmslklys eqytssskrk eefadmskvh svgsnglldf
       61 dseyqelwdw lidmeslvmd shdlmmseeq qqhlykrysv emsirhlkkt ellskvealk
      121 kggvllpndl lekvdsinek wellgktlge kiqdtmaghs gssprdllsp esgslvrqle
      181 vrikelkgwl rdtelfifns clrqekegtm ntekqlqyfk slcreikqrr rgvasilrlc
      241 qhllddretc nlnadhqpmq liivnlerrw eaivmqavqw qtrlqkkmgk esetlnvidp
      301 glmdlngmse dalewdemdi snklislnee sndldqelqp vipslklget snedpgydee
      361 adnhggsqya snitapssph iyqvyslhnv elyednhmpf lknnpkvtgm tqpnvltksl
      421 skdssfsstk slpdllggsn lvkpcachgg dmsqnsgses givsegdtet ttnsemclln
      481 avdgspsnle tehldpqmgd avnvlkqkft degesiklpn ssqssispvg cvngkvgdln
      541 sitkhtpdcl geelqgkhdv ftfydysylq gsklklpmim kqsqsekahv edpllrgfyf
      601 dkksckskhq ttelqpdvpp herilasash emdrisyksg niektftgmq nakqlsllsh
      661 sssieslspg gdlfglgifk ngsdslqrst sleswltsyk snedlfschs sgdisvssgs
      721 vgelskrtld llnrleniqs pseqkikrsv sditlqsssq kmsftgqmsl diassineds
      781 aasltelsss delslcsedi vlhknkipes nasfrkrltr svadesdvnv smivnvscts
      841 actddeddsd llssstltlt eeelcikded ddssiatdde iyedctlmsg ldyiknelqt
      901 wirpklsltr dkkrcnvsde mkgskdisss emtnpsdtln ietllngsvk rvsenngngk
      961 nsshthelgt krenkktifk vnkdpyvadm engniegipe rqkgkpnvts kvsenlgshg
     1021 keisesehck ckalmdsldd sntagkefvs qdvrhlpkkc pnhhhfenqs tastpteksf
     1081 selaletrfn nrqdsdalks sddapsmagk sagcclaleq ngteenasis nisccncepd
     1141 vfhqkdaedc svhnfvkeii dmastalksk sqpenevaap tsltqikekv lehshrpiql
     1201 rkgdfysyls lsshdsdcge vtnyieekss tplpldttds glddkediec ffeacvegds
     1261 dgeepcfssa ppnesavpse aamplqatac ssefsdssls addadtvals spssqeraev
     1321 gkevnglpqt ssgcaenlef tpskldseke ssgkpgesgm peehnaasak skvqdlslka
     1381 nqptdkaalh pspktltcee nllnlhekrh rnmhr
//
LOCUS       XP_011535681            1392 aa            linear   PRI 05-AUG-2025
DEFINITION  A-kinase anchor protein 6 isoform X5 [Homo sapiens].
ACCESSION   XP_011535681
VERSION     XP_011535681.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537379.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1392
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1392
                     /product="A-kinase anchor protein 6 isoform X5"
                     /calculated_mol_wt=153739
     Region          34..262
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            132..137
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     CDS             1..1392
                     /gene="AKAP6"
                     /gene_synonym="ADAP100; ADAP6; AKAP100; mAKAP; PRKA6"
                     /coded_by="XM_011537379.4:113..4291"
                     /db_xref="GeneID:9472"
                     /db_xref="HGNC:HGNC:376"
                     /db_xref="MIM:604691"
ORIGIN      
        1 mslklyseqy tssskrkeef admskvhsvg snglldfdse yqelwdwlid meslvmdshd
       61 lmmseeqqqh lykrysvems irhlkktell skvealkkgg vllpndllek vdsinekwel
      121 lgktlgekiq dtmaghsgss prdllspesg slvrqlevri kelkgwlrdt elfifnsclr
      181 qekegtmnte kqlqyfkslc reikqrrrgv asilrlcqhl lddretcnln adhqpmqlii
      241 vnlerrweai vmqavqwqtr lqkkmgkese tlnvidpglm dlngmsedal ewdemdisnk
      301 lislneesnd ldqelqpvip slklgetsne dpgydeeadn hggsqyasni tapssphiyq
      361 vyslhnvely ednhmpflkn npkvtgmtqp nvltkslskd ssfsstkslp dllggsnlvk
      421 pcachggdms qnsgsesgiv segdtetttn semcllnavd gspsnleteh ldpqmgdavn
      481 vlkqkftdeg esiklpnssq ssispvgcvn gkvgdlnsit khtpdclgee lqgkhdvftf
      541 ydysylqgsk lklpmimkqs qsekahvedp llrgfyfdkk sckskhqtte lqpdvppher
      601 ilasashemd risyksgnie ktftgmqnak qlsllshsss ieslspggdl fglgifkngs
      661 dslqrstsle swltsyksne dlfschssgd isvssgsvge lskrtldlln rleniqspse
      721 qkikrsvsdi tlqsssqkms ftgqmsldia ssinedsaas ltelsssdel slcsedivlh
      781 knkipesnas frkrltrsva desdvnvsmi vnvsctsact ddeddsdlls sstltlteee
      841 lcikdeddds siatddeiye dctlmsgldy iknelqtwir pklsltrdkk rcnvsdemkg
      901 skdisssemt npsdtlniet llngsvkrvs enngngknss hthelgtkre nkktifkvnk
      961 dpyvadmeng niegiperqk gkpnvtskvs enlgshgkei sesehckcka lmdslddsnt
     1021 agkefvsqdv rhlpkkcpnh hhfenqstas tpteksfsel aletrfnnrq dsdalkssdd
     1081 apsmagksag cclaleqngt eenasisnis ccncepdvfh qkdaedcsvh nfvkeiidma
     1141 stalksksqp enevaaptsl tqikekvleh shrpiqlrkg dfysylslss hdsdcgevtn
     1201 yieeksstpl pldttdsgld dkediecffe acvegdsdge epcfssappn esavpseaam
     1261 plqatacsse fsdsslsadd adtvalssps sqeraevgke vnglpqtssg caenleftps
     1321 kldsekessg kpgesgmpee hnaasakskv qdlslkanqp tdkaalhpsp ktltceenll
     1381 nlhekrhrnm hr
//
LOCUS       XP_011535685            1314 aa            linear   PRI 05-AUG-2025
DEFINITION  A-kinase anchor protein 6 isoform X6 [Homo sapiens].
ACCESSION   XP_011535685
VERSION     XP_011535685.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537383.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1314
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1314
                     /product="A-kinase anchor protein 6 isoform X6"
                     /calculated_mol_wt=144436
     Region          <10..184
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cl02488"
                     /db_xref="CDD:413338"
     Site            54..59
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238098"
     CDS             1..1314
                     /gene="AKAP6"
                     /gene_synonym="ADAP100; ADAP6; AKAP100; mAKAP; PRKA6"
                     /coded_by="XM_011537383.4:38..3982"
                     /db_xref="GeneID:9472"
                     /db_xref="HGNC:HGNC:376"
                     /db_xref="MIM:604691"
ORIGIN      
        1 msirhlkkte llskvealkk ggvllpndll ekvdsinekw ellgktlgek iqdtmaghsg
       61 ssprdllspe sgslvrqlev rikelkgwlr dtelfifnsc lrqekegtmn tekqlqyfks
      121 lcreikqrrr gvasilrlcq hllddretcn lnadhqpmql iivnlerrwe aivmqavqwq
      181 trlqkkmgke setlnvidpg lmdlngmsed alewdemdis nklislnees ndldqelqpv
      241 ipslklgets nedpgydeea dnhggsqyas nitapssphi yqvyslhnve lyednhmpfl
      301 knnpkvtgmt qpnvltksls kdssfsstks lpdllggsnl vkpcachggd msqnsgsesg
      361 ivsegdtett tnsemcllna vdgspsnlet ehldpqmgda vnvlkqkftd egesiklpns
      421 sqssispvgc vngkvgdlns itkhtpdclg eelqgkhdvf tfydysylqg sklklpmimk
      481 qsqsekahve dpllrgfyfd kksckskhqt telqpdvpph erilasashe mdrisyksgn
      541 iektftgmqn akqlsllshs ssieslspgg dlfglgifkn gsdslqrsts leswltsyks
      601 nedlfschss gdisvssgsv gelskrtldl lnrleniqsp seqkikrsvs ditlqsssqk
      661 msftgqmsld iassinedsa asltelsssd elslcsediv lhknkipesn asfrkrltrs
      721 vadesdvnvs mivnvsctsa ctddeddsdl lssstltlte eelcikdedd dssiatddei
      781 yedctlmsgl dyiknelqtw irpklsltrd kkrcnvsdem kgskdissse mtnpsdtlni
      841 etllngsvkr vsenngngkn sshthelgtk renkktifkv nkdpyvadme ngniegiper
      901 qkgkpnvtsk vsenlgshgk eisesehckc kalmdsldds ntagkefvsq dvrhlpkkcp
      961 nhhhfenqst astpteksfs elaletrfnn rqdsdalkss ddapsmagks agcclaleqn
     1021 gteenasisn isccncepdv fhqkdaedcs vhnfvkeiid mastalksks qpenevaapt
     1081 sltqikekvl ehshrpiqlr kgdfysylsl sshdsdcgev tnyieeksst plpldttdsg
     1141 lddkediecf feacvegdsd geepcfssap pnesavpsea amplqatacs sefsdsslsa
     1201 ddadtvalss pssqeraevg kevnglpqts sgcaenleft pskldsekes sgkpgesgmp
     1261 eehnaasaks kvqdlslkan qptdkaalhp spktltceen llnlhekrhr nmhr
//
LOCUS       XP_005268284            1728 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase MRCK beta isoform X1 [Homo
            sapiens].
ACCESSION   XP_005268284
VERSION     XP_005268284.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005268227.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1728
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1728
                     /product="serine/threonine-protein kinase MRCK beta
                     isoform X1"
                     /calculated_mol_wt=195983
     Region          3..411
                     /region_name="STKc_MRCK_beta"
                     /note="Catalytic domain of the Protein Serine/Threonine
                     Kinase, DMPK-related cell division control protein 42
                     binding kinase (MRCK) beta; cd05624"
                     /db_xref="CDD:270774"
     Site            order(3..4,6..7,10..11,14..15,24..25,27,29..30,33..34,37,
                     46,51..52,55,58,62,65,68..72,75,95,98,100,113,141,393,
                     396..397,399,406..409)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:270774"
     Site            order(82..86,90,103,105,137,153..154,156,160,162,200,202,
                     204..205,207,217..218,221,236..241,273,279,282)
                     /site_type="active"
                     /db_xref="CDD:270774"
     Site            order(82..86,90,103,105,137,154..156,160,200,202,204..205,
                     207,217..218)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270774"
     Site            order(86,160,162,200,202,204,221,236..241,273,279,282)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270774"
     Site            217..241
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270774"
     Site            398..403
                     /site_type="other"
                     /note="hydrophobic motif (HM)"
                     /db_xref="CDD:270774"
     Region          <426..>937
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          527..606
                     /region_name="KELK"
                     /note="KELK-motif containing domain of MRCK Ser/Thr
                     protein kinase; pfam15796"
                     /db_xref="CDD:464876"
     Region          1043..1095
                     /region_name="C1_MRCKbeta"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in myotonic dystrophy kinase-related Cdc42-binding
                     kinase beta (MRCK beta) and similar proteins; cd20865"
                     /db_xref="CDD:410415"
     Site            order(1048..1054,1062..1066,1069)
                     /site_type="other"
                     /note="putative DAG/PE binding site [chemical binding]"
                     /db_xref="CDD:410415"
     Region          1102..1236
                     /region_name="PH_MRCK"
                     /note="MRCK (myotonic dystrophy-related Cdc42-binding
                     kinase) pleckstrin homology (PH) domain; cd01243"
                     /db_xref="CDD:269949"
     Region          1267..1526
                     /region_name="CNH"
                     /note="CNH domain; pfam00780"
                     /db_xref="CDD:459938"
     CDS             1..1728
                     /gene="CDC42BPB"
                     /gene_synonym="CHOCNS; MRCKB"
                     /coded_by="XM_005268227.2:377..5563"
                     /db_xref="GeneID:9578"
                     /db_xref="HGNC:HGNC:1738"
                     /db_xref="MIM:614062"
ORIGIN      
        1 msakvrlkkl eqllldgpwr nesalsvetl ldvlvclyte cshsalrrdk yvaeflewak
       61 pftqlvkemq lhredfeiik vigrgafgev avvkmknter iyamkilnkw emlkraetac
      121 freerdvlvn gdcqwitalh yafqdenhly lvmdyyvggd lltllskfed klpedmarfy
      181 igemvlaids ihqlhyvhrd ikpdnvlldv nghirladfg sclkmnddgt vqssvavgtp
      241 dyispeilqa medgmgkygp ecdwwslgvc myemlygetp fyaeslvety gkimnheerf
      301 qfpshvtdvs eeakdliqrl icsrerrlgq ngiedfkkha ffeglnweni rnleapyipd
      361 vsspsdtsnf dvdddvlrnt eilppgshtg fsglhlpfig ftfttescfs drgslksimq
      421 sntltkdedv qrdlehslqm eayerrirrl eqeklelsrk lqestqtvqs lhgssralsn
      481 snrdkeikkl neeierlknk iadsnrlerq ledtvalrqe redstqrlrg lekqhrvvrq
      541 ekeelhkqlv easerlksqa kelkdahqqr klalqefsel nermaelraq kqkvsrqlrd
      601 keeemevatq kvdamrqemr raeklrkele aqlddavaea skerklrehs enfckqmese
      661 lealkvkqgg rgagatlehq qeiskiksel ekkvlfyeee lvrreashvl evknvkkevh
      721 dseshqlalq keilmlkdkl ekskrerhne meeavgtikd kyereramlf denkkltaen
      781 eklcsfvdkl taqnrqlede lqdlaakkes vahweaqiae iiqwvsdekd argylqalas
      841 kmteelealr ssslgsrtld plwkvrrsqk ldmsarlelq saleaeirak qlvqeelrkv
      901 kdanltlesk lkdseaknre lleemeilkk kmeekfradt glklpdfqds ifeyfntapl
      961 ahdltfrdsl ssssasslla fweetssase qetqapkpea spsmsvaase qqedmarppq
     1021 rpsavplptt qalalagpkp kahqfsiksf ssptqcshct slmvglirqg yacevcsfac
     1081 hvsckdgapq vcpippeqsk rplgvdvqrg igtaykghvk vpkptgvkkg wqrayavvcd
     1141 cklflydlpe gkstqpgvia sqvldlrdde fsvssvlasd vihatrrdip cifrvtasll
     1201 gapsktssll iltenenekr kwvgileglq silhknrlrn qvvhvpleay dsslplikai
     1261 ltaaivdadr iavgleegly vievtrdviv raadckkvhq ielaprekiv illcgrnhhv
     1321 hlypwssldg aegsfdiklp etkgcqlmat atlkrnsgtc lfvavkrlil cyeiqrtkpf
     1381 hrkfneivap gsvqclavlr drlcvgypsg fcllsiqgdg qplnlvnpnd pslaflsqqs
     1441 fdalcavele seeyllcfsh mglyvdpqgr raraqelmwp aapvacscsp thvtvyseyg
     1501 vdvfdvrtme wvqtiglrri rplnsegtln llncepprli yfkskfsgav lnvpdtsdns
     1561 kkqmlrtrsk rrfvfkvpee erlqqrreml rdpelrskmi snptnfnhva hmgpgdgmqv
     1621 lmdlplsavp psqeerpgpa ptnlarqpps rnkpyiswps sggsepsvtv plrsmsdpdq
     1681 dfdkepdsds tkhstpsnss npsgppspns phrsqlpleg leqpacdt
//
LOCUS       XP_005268285            1702 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase MRCK beta isoform X2 [Homo
            sapiens].
ACCESSION   XP_005268285
VERSION     XP_005268285.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005268228.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1702
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1702
                     /product="serine/threonine-protein kinase MRCK beta
                     isoform X2"
                     /calculated_mol_wt=193317
     Region          3..411
                     /region_name="STKc_MRCK_beta"
                     /note="Catalytic domain of the Protein Serine/Threonine
                     Kinase, DMPK-related cell division control protein 42
                     binding kinase (MRCK) beta; cd05624"
                     /db_xref="CDD:270774"
     Site            order(3..4,6..7,10..11,14..15,24..25,27,29..30,33..34,37,
                     46,51..52,55,58,62,65,68..72,75,95,98,100,113,141,393,
                     396..397,399,406..409)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:270774"
     Site            order(82..86,90,103,105,137,153..154,156,160,162,200,202,
                     204..205,207,217..218,221,236..241,273,279,282)
                     /site_type="active"
                     /db_xref="CDD:270774"
     Site            order(82..86,90,103,105,137,154..156,160,200,202,204..205,
                     207,217..218)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270774"
     Site            order(86,160,162,200,202,204,221,236..241,273,279,282)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270774"
     Site            217..241
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270774"
     Site            398..403
                     /site_type="other"
                     /note="hydrophobic motif (HM)"
                     /db_xref="CDD:270774"
     Region          <426..>937
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          527..606
                     /region_name="KELK"
                     /note="KELK-motif containing domain of MRCK Ser/Thr
                     protein kinase; pfam15796"
                     /db_xref="CDD:464876"
     Region          1017..1069
                     /region_name="C1_MRCKbeta"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in myotonic dystrophy kinase-related Cdc42-binding
                     kinase beta (MRCK beta) and similar proteins; cd20865"
                     /db_xref="CDD:410415"
     Site            order(1022..1028,1036..1040,1043)
                     /site_type="other"
                     /note="putative DAG/PE binding site [chemical binding]"
                     /db_xref="CDD:410415"
     Region          1076..1210
                     /region_name="PH_MRCK"
                     /note="MRCK (myotonic dystrophy-related Cdc42-binding
                     kinase) pleckstrin homology (PH) domain; cd01243"
                     /db_xref="CDD:269949"
     Region          1241..1500
                     /region_name="CNH"
                     /note="CNH domain; pfam00780"
                     /db_xref="CDD:459938"
     CDS             1..1702
                     /gene="CDC42BPB"
                     /gene_synonym="CHOCNS; MRCKB"
                     /coded_by="XM_005268228.2:377..5485"
                     /db_xref="GeneID:9578"
                     /db_xref="HGNC:HGNC:1738"
                     /db_xref="MIM:614062"
ORIGIN      
        1 msakvrlkkl eqllldgpwr nesalsvetl ldvlvclyte cshsalrrdk yvaeflewak
       61 pftqlvkemq lhredfeiik vigrgafgev avvkmknter iyamkilnkw emlkraetac
      121 freerdvlvn gdcqwitalh yafqdenhly lvmdyyvggd lltllskfed klpedmarfy
      181 igemvlaids ihqlhyvhrd ikpdnvlldv nghirladfg sclkmnddgt vqssvavgtp
      241 dyispeilqa medgmgkygp ecdwwslgvc myemlygetp fyaeslvety gkimnheerf
      301 qfpshvtdvs eeakdliqrl icsrerrlgq ngiedfkkha ffeglnweni rnleapyipd
      361 vsspsdtsnf dvdddvlrnt eilppgshtg fsglhlpfig ftfttescfs drgslksimq
      421 sntltkdedv qrdlehslqm eayerrirrl eqeklelsrk lqestqtvqs lhgssralsn
      481 snrdkeikkl neeierlknk iadsnrlerq ledtvalrqe redstqrlrg lekqhrvvrq
      541 ekeelhkqlv easerlksqa kelkdahqqr klalqefsel nermaelraq kqkvsrqlrd
      601 keeemevatq kvdamrqemr raeklrkele aqlddavaea skerklrehs enfckqmese
      661 lealkvkqgg rgagatlehq qeiskiksel ekkvlfyeee lvrreashvl evknvkkevh
      721 dseshqlalq keilmlkdkl ekskrerhne meeavgtikd kyereramlf denkkltaen
      781 eklcsfvdkl taqnrqlede lqdlaakkes vahweaqiae iiqwvsdekd argylqalas
      841 kmteelealr ssslgsrtld plwkvrrsqk ldmsarlelq saleaeirak qlvqeelrkv
      901 kdanltlesk lkdseaknre lleemeilkk kmeekfradt glklpdfqds ifeyfntapl
      961 ahdltfrdsl ssssasslla fweetssase qetqapkpea spsmsvaase qqepkahqfs
     1021 iksfssptqc shctslmvgl irqgyacevc sfachvsckd gapqvcpipp eqskrplgvd
     1081 vqrgigtayk ghvkvpkptg vkkgwqraya vvcdcklfly dlpegkstqp gviasqvldl
     1141 rddefsvssv lasdvihatr rdipcifrvt asllgapskt sslliltene nekrkwvgil
     1201 eglqsilhkn rlrnqvvhvp leaydsslpl ikailtaaiv dadriavgle eglyvievtr
     1261 dvivraadck kvhqielapr ekivillcgr nhhvhlypws sldgaegsfd iklpetkgcq
     1321 lmatatlkrn sgtclfvavk rlilcyeiqr tkpfhrkfne ivapgsvqcl avlrdrlcvg
     1381 ypsgfcllsi qgdgqplnlv npndpslafl sqqsfdalca veleseeyll cfshmglyvd
     1441 pqgrraraqe lmwpaapvac scspthvtvy seygvdvfdv rtmewvqtig lrrirplnse
     1501 gtlnllncep prliyfkskf sgavlnvpdt sdnskkqmlr trskrrfvfk vpeeerlqqr
     1561 remlrdpelr skmisnptnf nhvahmgpgd gmqvlmdlpl savppsqeer pgpaptnlar
     1621 qppsrnkpyi swpssggsep svtvplrsms dpdqdfdkep dsdstkhstp snssnpsgpp
     1681 spnsphrsql plegleqpac dt
//
LOCUS       XP_005268287            1490 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase MRCK beta isoform X3 [Homo
            sapiens].
ACCESSION   XP_005268287
VERSION     XP_005268287.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005268230.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1490
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1490
                     /product="serine/threonine-protein kinase MRCK beta
                     isoform X3"
                     /calculated_mol_wt=169455
     Region          3..411
                     /region_name="STKc_MRCK_beta"
                     /note="Catalytic domain of the Protein Serine/Threonine
                     Kinase, DMPK-related cell division control protein 42
                     binding kinase (MRCK) beta; cd05624"
                     /db_xref="CDD:270774"
     Site            order(3..4,6..7,10..11,14..15,24..25,27,29..30,33..34,37,
                     46,51..52,55,58,62,65,68..72,75,95,98,100,113,141,393,
                     396..397,399,406..409)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:270774"
     Site            order(82..86,90,103,105,137,153..154,156,160,162,200,202,
                     204..205,207,217..218,221,236..241,273,279,282)
                     /site_type="active"
                     /db_xref="CDD:270774"
     Site            order(82..86,90,103,105,137,154..156,160,200,202,204..205,
                     207,217..218)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270774"
     Site            order(86,160,162,200,202,204,221,236..241,273,279,282)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270774"
     Site            217..241
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270774"
     Site            398..403
                     /site_type="other"
                     /note="hydrophobic motif (HM)"
                     /db_xref="CDD:270774"
     Region          <426..>937
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          527..606
                     /region_name="KELK"
                     /note="KELK-motif containing domain of MRCK Ser/Thr
                     protein kinase; pfam15796"
                     /db_xref="CDD:464876"
     Region          1043..1095
                     /region_name="C1_MRCKbeta"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in myotonic dystrophy kinase-related Cdc42-binding
                     kinase beta (MRCK beta) and similar proteins; cd20865"
                     /db_xref="CDD:410415"
     Site            order(1048..1054,1062..1066,1069)
                     /site_type="other"
                     /note="putative DAG/PE binding site [chemical binding]"
                     /db_xref="CDD:410415"
     Region          1102..1236
                     /region_name="PH_MRCK"
                     /note="MRCK (myotonic dystrophy-related Cdc42-binding
                     kinase) pleckstrin homology (PH) domain; cd01243"
                     /db_xref="CDD:269949"
     Region          1267..1486
                     /region_name="CNH"
                     /note="CNH domain; pfam00780"
                     /db_xref="CDD:459938"
     CDS             1..1490
                     /gene="CDC42BPB"
                     /gene_synonym="CHOCNS; MRCKB"
                     /coded_by="XM_005268230.5:377..4849"
                     /db_xref="GeneID:9578"
                     /db_xref="HGNC:HGNC:1738"
                     /db_xref="MIM:614062"
ORIGIN      
        1 msakvrlkkl eqllldgpwr nesalsvetl ldvlvclyte cshsalrrdk yvaeflewak
       61 pftqlvkemq lhredfeiik vigrgafgev avvkmknter iyamkilnkw emlkraetac
      121 freerdvlvn gdcqwitalh yafqdenhly lvmdyyvggd lltllskfed klpedmarfy
      181 igemvlaids ihqlhyvhrd ikpdnvlldv nghirladfg sclkmnddgt vqssvavgtp
      241 dyispeilqa medgmgkygp ecdwwslgvc myemlygetp fyaeslvety gkimnheerf
      301 qfpshvtdvs eeakdliqrl icsrerrlgq ngiedfkkha ffeglnweni rnleapyipd
      361 vsspsdtsnf dvdddvlrnt eilppgshtg fsglhlpfig ftfttescfs drgslksimq
      421 sntltkdedv qrdlehslqm eayerrirrl eqeklelsrk lqestqtvqs lhgssralsn
      481 snrdkeikkl neeierlknk iadsnrlerq ledtvalrqe redstqrlrg lekqhrvvrq
      541 ekeelhkqlv easerlksqa kelkdahqqr klalqefsel nermaelraq kqkvsrqlrd
      601 keeemevatq kvdamrqemr raeklrkele aqlddavaea skerklrehs enfckqmese
      661 lealkvkqgg rgagatlehq qeiskiksel ekkvlfyeee lvrreashvl evknvkkevh
      721 dseshqlalq keilmlkdkl ekskrerhne meeavgtikd kyereramlf denkkltaen
      781 eklcsfvdkl taqnrqlede lqdlaakkes vahweaqiae iiqwvsdekd argylqalas
      841 kmteelealr ssslgsrtld plwkvrrsqk ldmsarlelq saleaeirak qlvqeelrkv
      901 kdanltlesk lkdseaknre lleemeilkk kmeekfradt glklpdfqds ifeyfntapl
      961 ahdltfrdsl ssssasslla fweetssase qetqapkpea spsmsvaase qqedmarppq
     1021 rpsavplptt qalalagpkp kahqfsiksf ssptqcshct slmvglirqg yacevcsfac
     1081 hvsckdgapq vcpippeqsk rplgvdvqrg igtaykghvk vpkptgvkkg wqrayavvcd
     1141 cklflydlpe gkstqpgvia sqvldlrdde fsvssvlasd vihatrrdip cifrvtasll
     1201 gapsktssll iltenenekr kwvgileglq silhknrlrn qvvhvpleay dsslplikai
     1261 ltaaivdadr iavgleegly vievtrdviv raadckkvhq ielaprekiv illcgrnhhv
     1321 hlypwssldg aegsfdiklp etkgcqlmat atlkrnsgtc lfvavkrlil cyeiqrtkpf
     1381 hrkfneivap gsvqclavlr drlcvgypsg fcllsiqgdg qplnlvnpnd pslaflsqqs
     1441 fdalcavele seeyllcfsh mglyvdpqgr raraqelmwp aapvackeks
//
LOCUS       XP_011535689            1460 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase MRCK beta isoform X4 [Homo
            sapiens].
ACCESSION   XP_011535689
VERSION     XP_011535689.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537387.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1460
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1460
                     /product="serine/threonine-protein kinase MRCK beta
                     isoform X4"
                     /calculated_mol_wt=166216
     Region          3..411
                     /region_name="STKc_MRCK_beta"
                     /note="Catalytic domain of the Protein Serine/Threonine
                     Kinase, DMPK-related cell division control protein 42
                     binding kinase (MRCK) beta; cd05624"
                     /db_xref="CDD:270774"
     Site            order(3..4,6..7,10..11,14..15,24..25,27,29..30,33..34,37,
                     46,51..52,55,58,62,65,68..72,75,95,98,100,113,141,393,
                     396..397,399,406..409)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:270774"
     Site            order(82..86,90,103,105,137,153..154,156,160,162,200,202,
                     204..205,207,217..218,221,236..241,273,279,282)
                     /site_type="active"
                     /db_xref="CDD:270774"
     Site            order(82..86,90,103,105,137,154..156,160,200,202,204..205,
                     207,217..218)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270774"
     Site            order(86,160,162,200,202,204,221,236..241,273,279,282)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270774"
     Site            217..241
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270774"
     Site            398..403
                     /site_type="other"
                     /note="hydrophobic motif (HM)"
                     /db_xref="CDD:270774"
     Region          <426..>937
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          527..606
                     /region_name="KELK"
                     /note="KELK-motif containing domain of MRCK Ser/Thr
                     protein kinase; pfam15796"
                     /db_xref="CDD:464876"
     Region          1043..1095
                     /region_name="C1_MRCKbeta"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in myotonic dystrophy kinase-related Cdc42-binding
                     kinase beta (MRCK beta) and similar proteins; cd20865"
                     /db_xref="CDD:410415"
     Site            order(1048..1054,1062..1066,1069)
                     /site_type="other"
                     /note="putative DAG/PE binding site [chemical binding]"
                     /db_xref="CDD:410415"
     Region          1102..1236
                     /region_name="PH_MRCK"
                     /note="MRCK (myotonic dystrophy-related Cdc42-binding
                     kinase) pleckstrin homology (PH) domain; cd01243"
                     /db_xref="CDD:269949"
     Region          1267..>1438
                     /region_name="CNH"
                     /note="CNH domain; cl02434"
                     /db_xref="CDD:470577"
     CDS             1..1460
                     /gene="CDC42BPB"
                     /gene_synonym="CHOCNS; MRCKB"
                     /coded_by="XM_011537387.2:377..4759"
                     /db_xref="GeneID:9578"
                     /db_xref="HGNC:HGNC:1738"
                     /db_xref="MIM:614062"
ORIGIN      
        1 msakvrlkkl eqllldgpwr nesalsvetl ldvlvclyte cshsalrrdk yvaeflewak
       61 pftqlvkemq lhredfeiik vigrgafgev avvkmknter iyamkilnkw emlkraetac
      121 freerdvlvn gdcqwitalh yafqdenhly lvmdyyvggd lltllskfed klpedmarfy
      181 igemvlaids ihqlhyvhrd ikpdnvlldv nghirladfg sclkmnddgt vqssvavgtp
      241 dyispeilqa medgmgkygp ecdwwslgvc myemlygetp fyaeslvety gkimnheerf
      301 qfpshvtdvs eeakdliqrl icsrerrlgq ngiedfkkha ffeglnweni rnleapyipd
      361 vsspsdtsnf dvdddvlrnt eilppgshtg fsglhlpfig ftfttescfs drgslksimq
      421 sntltkdedv qrdlehslqm eayerrirrl eqeklelsrk lqestqtvqs lhgssralsn
      481 snrdkeikkl neeierlknk iadsnrlerq ledtvalrqe redstqrlrg lekqhrvvrq
      541 ekeelhkqlv easerlksqa kelkdahqqr klalqefsel nermaelraq kqkvsrqlrd
      601 keeemevatq kvdamrqemr raeklrkele aqlddavaea skerklrehs enfckqmese
      661 lealkvkqgg rgagatlehq qeiskiksel ekkvlfyeee lvrreashvl evknvkkevh
      721 dseshqlalq keilmlkdkl ekskrerhne meeavgtikd kyereramlf denkkltaen
      781 eklcsfvdkl taqnrqlede lqdlaakkes vahweaqiae iiqwvsdekd argylqalas
      841 kmteelealr ssslgsrtld plwkvrrsqk ldmsarlelq saleaeirak qlvqeelrkv
      901 kdanltlesk lkdseaknre lleemeilkk kmeekfradt glklpdfqds ifeyfntapl
      961 ahdltfrdsl ssssasslla fweetssase qetqapkpea spsmsvaase qqedmarppq
     1021 rpsavplptt qalalagpkp kahqfsiksf ssptqcshct slmvglirqg yacevcsfac
     1081 hvsckdgapq vcpippeqsk rplgvdvqrg igtaykghvk vpkptgvkkg wqrayavvcd
     1141 cklflydlpe gkstqpgvia sqvldlrdde fsvssvlasd vihatrrdip cifrvtasll
     1201 gapsktssll iltenenekr kwvgileglq silhknrlrn qvvhvpleay dsslplikai
     1261 ltaaivdadr iavgleegly vievtrdviv raadckkvhq ielaprekiv illcgrnhhv
     1321 hlypwssldg aegsfdiklp etkgcqlmat atlkrnsgtc lfvavkrlil cyeiqrtkpf
     1381 hrkfneivap gsvqclavlr drlcvgypsg fcllsiqgdg qplnlkkspd lvaclesvie
     1441 teqkafkmhl qtvrcvlmqd
//
LOCUS       XP_047287937            1458 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase MRCK beta isoform X5 [Homo
            sapiens].
ACCESSION   XP_047287937
VERSION     XP_047287937.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431981.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1458
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1458
                     /product="serine/threonine-protein kinase MRCK beta
                     isoform X5"
                     /calculated_mol_wt=165511
     Region          3..411
                     /region_name="STKc_MRCK_beta"
                     /note="Catalytic domain of the Protein Serine/Threonine
                     Kinase, DMPK-related cell division control protein 42
                     binding kinase (MRCK) beta; cd05624"
                     /db_xref="CDD:270774"
     Site            order(3..4,6..7,10..11,14..15,24..25,27,29..30,33..34,37,
                     46,51..52,55,58,62,65,68..72,75,95,98,100,113,141,393,
                     396..397,399,406..409)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:270774"
     Site            order(82..86,90,103,105,137,153..154,156,160,162,200,202,
                     204..205,207,217..218,221,236..241,273,279,282)
                     /site_type="active"
                     /db_xref="CDD:270774"
     Site            order(82..86,90,103,105,137,154..156,160,200,202,204..205,
                     207,217..218)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270774"
     Site            order(86,160,162,200,202,204,221,236..241,273,279,282)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270774"
     Site            217..241
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270774"
     Site            398..403
                     /site_type="other"
                     /note="hydrophobic motif (HM)"
                     /db_xref="CDD:270774"
     Region          <426..>934
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          527..606
                     /region_name="KELK"
                     /note="KELK-motif containing domain of MRCK Ser/Thr
                     protein kinase; pfam15796"
                     /db_xref="CDD:464876"
     Region          1043..1095
                     /region_name="C1_MRCKbeta"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in myotonic dystrophy kinase-related Cdc42-binding
                     kinase beta (MRCK beta) and similar proteins; cd20865"
                     /db_xref="CDD:410415"
     Site            order(1048..1054,1062..1066,1069)
                     /site_type="other"
                     /note="putative DAG/PE binding site [chemical binding]"
                     /db_xref="CDD:410415"
     Region          1102..1236
                     /region_name="PH_MRCK"
                     /note="MRCK (myotonic dystrophy-related Cdc42-binding
                     kinase) pleckstrin homology (PH) domain; cd01243"
                     /db_xref="CDD:269949"
     Region          1267..>1416
                     /region_name="CNH"
                     /note="CNH domain; cl02434"
                     /db_xref="CDD:470577"
     CDS             1..1458
                     /gene="CDC42BPB"
                     /gene_synonym="CHOCNS; MRCKB"
                     /coded_by="XM_047431981.1:377..4753"
                     /db_xref="GeneID:9578"
                     /db_xref="HGNC:HGNC:1738"
                     /db_xref="MIM:614062"
ORIGIN      
        1 msakvrlkkl eqllldgpwr nesalsvetl ldvlvclyte cshsalrrdk yvaeflewak
       61 pftqlvkemq lhredfeiik vigrgafgev avvkmknter iyamkilnkw emlkraetac
      121 freerdvlvn gdcqwitalh yafqdenhly lvmdyyvggd lltllskfed klpedmarfy
      181 igemvlaids ihqlhyvhrd ikpdnvlldv nghirladfg sclkmnddgt vqssvavgtp
      241 dyispeilqa medgmgkygp ecdwwslgvc myemlygetp fyaeslvety gkimnheerf
      301 qfpshvtdvs eeakdliqrl icsrerrlgq ngiedfkkha ffeglnweni rnleapyipd
      361 vsspsdtsnf dvdddvlrnt eilppgshtg fsglhlpfig ftfttescfs drgslksimq
      421 sntltkdedv qrdlehslqm eayerrirrl eqeklelsrk lqestqtvqs lhgssralsn
      481 snrdkeikkl neeierlknk iadsnrlerq ledtvalrqe redstqrlrg lekqhrvvrq
      541 ekeelhkqlv easerlksqa kelkdahqqr klalqefsel nermaelraq kqkvsrqlrd
      601 keeemevatq kvdamrqemr raeklrkele aqlddavaea skerklrehs enfckqmese
      661 lealkvkqgg rgagatlehq qeiskiksel ekkvlfyeee lvrreashvl evknvkkevh
      721 dseshqlalq keilmlkdkl ekskrerhne meeavgtikd kyereramlf denkkltaen
      781 eklcsfvdkl taqnrqlede lqdlaakkes vahweaqiae iiqwvsdekd argylqalas
      841 kmteelealr ssslgsrtld plwkvrrsqk ldmsarlelq saleaeirak qlvqeelrkv
      901 kdanltlesk lkdseaknre lleemeilkk kmeekfradt glklpdfqds ifeyfntapl
      961 ahdltfrdsl ssssasslla fweetssase qetqapkpea spsmsvaase qqedmarppq
     1021 rpsavplptt qalalagpkp kahqfsiksf ssptqcshct slmvglirqg yacevcsfac
     1081 hvsckdgapq vcpippeqsk rplgvdvqrg igtaykghvk vpkptgvkkg wqrayavvcd
     1141 cklflydlpe gkstqpgvia sqvldlrdde fsvssvlasd vihatrrdip cifrvtasll
     1201 gapsktssll iltenenekr kwvgileglq silhknrlrn qvvhvpleay dsslplikai
     1261 ltaaivdadr iavgleegly vievtrdviv raadckkvhq ielaprekiv illcgrnhhv
     1321 hlypwssldg aegsfdiklp etkgcqlmat atlkrnsgtc lfvavkrlil cyeiqrtkpf
     1381 hrkfneivap gsvqclavlr drlcvgypsg fcllsiqgdg qplnlvaapp tsrctasmaw
     1441 tslmcapwsg crpsacgg
//
LOCUS       XP_047287938            1415 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase MRCK beta isoform X6 [Homo
            sapiens].
ACCESSION   XP_047287938
VERSION     XP_047287938.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431982.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1415
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1415
                     /product="serine/threonine-protein kinase MRCK beta
                     isoform X6"
                     /calculated_mol_wt=161047
     Region          3..411
                     /region_name="STKc_MRCK_beta"
                     /note="Catalytic domain of the Protein Serine/Threonine
                     Kinase, DMPK-related cell division control protein 42
                     binding kinase (MRCK) beta; cd05624"
                     /db_xref="CDD:270774"
     Site            order(3..4,6..7,10..11,14..15,24..25,27,29..30,33..34,37,
                     46,51..52,55,58,62,65,68..72,75,95,98,100,113,141,393,
                     396..397,399,406..409)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:270774"
     Site            order(82..86,90,103,105,137,153..154,156,160,162,200,202,
                     204..205,207,217..218,221,236..241,273,279,282)
                     /site_type="active"
                     /db_xref="CDD:270774"
     Site            order(82..86,90,103,105,137,154..156,160,200,202,204..205,
                     207,217..218)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270774"
     Site            order(86,160,162,200,202,204,221,236..241,273,279,282)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270774"
     Site            217..241
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270774"
     Site            398..403
                     /site_type="other"
                     /note="hydrophobic motif (HM)"
                     /db_xref="CDD:270774"
     Region          <426..>937
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          527..606
                     /region_name="KELK"
                     /note="KELK-motif containing domain of MRCK Ser/Thr
                     protein kinase; pfam15796"
                     /db_xref="CDD:464876"
     Region          1000..1052
                     /region_name="C1_MRCKbeta"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in myotonic dystrophy kinase-related Cdc42-binding
                     kinase beta (MRCK beta) and similar proteins; cd20865"
                     /db_xref="CDD:410415"
     Site            order(1005..1011,1019..1023,1026)
                     /site_type="other"
                     /note="putative DAG/PE binding site [chemical binding]"
                     /db_xref="CDD:410415"
     Region          1059..1193
                     /region_name="PH_MRCK"
                     /note="MRCK (myotonic dystrophy-related Cdc42-binding
                     kinase) pleckstrin homology (PH) domain; cd01243"
                     /db_xref="CDD:269949"
     Region          1224..>1373
                     /region_name="CNH"
                     /note="CNH domain; cl02434"
                     /db_xref="CDD:470577"
     CDS             1..1415
                     /gene="CDC42BPB"
                     /gene_synonym="CHOCNS; MRCKB"
                     /coded_by="XM_047431982.1:377..4624"
                     /db_xref="GeneID:9578"
                     /db_xref="HGNC:HGNC:1738"
                     /db_xref="MIM:614062"
ORIGIN      
        1 msakvrlkkl eqllldgpwr nesalsvetl ldvlvclyte cshsalrrdk yvaeflewak
       61 pftqlvkemq lhredfeiik vigrgafgev avvkmknter iyamkilnkw emlkraetac
      121 freerdvlvn gdcqwitalh yafqdenhly lvmdyyvggd lltllskfed klpedmarfy
      181 igemvlaids ihqlhyvhrd ikpdnvlldv nghirladfg sclkmnddgt vqssvavgtp
      241 dyispeilqa medgmgkygp ecdwwslgvc myemlygetp fyaeslvety gkimnheerf
      301 qfpshvtdvs eeakdliqrl icsrerrlgq ngiedfkkha ffeglnweni rnleapyipd
      361 vsspsdtsnf dvdddvlrnt eilppgshtg fsglhlpfig ftfttescfs drgslksimq
      421 sntltkdedv qrdlehslqm eayerrirrl eqeklelsrk lqestqtvqs lhgssralsn
      481 snrdkeikkl neeierlknk iadsnrlerq ledtvalrqe redstqrlrg lekqhrvvrq
      541 ekeelhkqlv easerlksqa kelkdahqqr klalqefsel nermaelraq kqkvsrqlrd
      601 keeemevatq kvdamrqemr raeklrkele aqlddavaea skerklrehs enfckqmese
      661 lealkvkqgg rgagatlehq qeiskiksel ekkvlfyeee lvrreashvl evknvkkevh
      721 dseshqlalq keilmlkdkl ekskrerhne meeavgtikd kyereramlf denkkltaen
      781 eklcsfvdkl taqnrqlede lqdlaakkes vahweaqiae iiqwvsdekd argylqalas
      841 kmteelealr ssslgsrtld plwkvrrsqk ldmsarlelq saleaeirak qlvqeelrkv
      901 kdanltlesk lkdseaknre lleemeilkk kmeekfradt glklpdfqds ifeyfntapl
      961 ahdltfrtss aseqetqapk peaspsmsva aseqqepkah qfsiksfssp tqcshctslm
     1021 vglirqgyac evcsfachvs ckdgapqvcp ippeqskrpl gvdvqrgigt aykghvkvpk
     1081 ptgvkkgwqr ayavvcdckl flydlpegks tqpgviasqv ldlrddefsv ssvlasdvih
     1141 atrrdipcif rvtasllgap sktssllilt enenekrkwv gileglqsil hknrlrnqvv
     1201 hvpleaydss lplikailta aivdadriav gleeglyvie vtrdvivraa dckkvhqiel
     1261 aprekivill cgrnhhvhly pwssldgaeg sfdiklpetk gcqlmatatl krnsgtclfv
     1321 avkrlilcye iqrtkpfhrk fneivapgsv qclavlrdrl cvgypsgfcl lsiqgdgqpl
     1381 nlvaapptsr ctasmawtsl mcapwsgcrp sacgg
//
LOCUS       XP_024305527             684 aa            linear   PRI 05-AUG-2025
DEFINITION  regulator of G-protein signaling 6 isoform X1 [Homo sapiens].
ACCESSION   XP_024305527
VERSION     XP_024305527.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449759.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..684
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..684
                     /product="regulator of G-protein signaling 6 isoform X1"
                     /calculated_mol_wt=76924
     Region          31..119
                     /region_name="DEP_RGS7-like"
                     /note="DEP (Dishevelled, Egl-10, and Pleckstrin) domain
                     found in RGS (regulator of G-protein signaling) proteins
                     of the subfamily R7. This subgroup contains RGS7, RGS6,
                     RGS9 and RGS11. They share a common domain architecture,
                     containing, beside the RGS domain; cd04450"
                     /db_xref="CDD:239897"
     Region          116..217
                     /region_name="RGS_DHEX"
                     /note="Regulator of G-protein signalling DHEX domain;
                     pfam18148"
                     /db_xref="CDD:375589"
     Region          258..319
                     /region_name="GGL"
                     /note="G protein gamma subunit-like motifs; smart00224"
                     /db_xref="CDD:128520"
     Site            order(258,261,265,268,272,277,279,282..283,286..287,290,
                     299..300,309)
                     /site_type="other"
                     /note="beta subunit binding site [polypeptide binding]"
                     /db_xref="CDD:238024"
     Region          328..452
                     /region_name="RGS_RGS6"
                     /note="Regulator of G protein signaling (RGS) domain found
                     in the RGS6 protein; cd08737"
                     /db_xref="CDD:188691"
     Site            order(342,373..377,418..420,423,430,434)
                     /site_type="other"
                     /note="G-beta-5 interaction site"
                     /db_xref="CDD:188691"
     Site            order(357..359,361..362,395..397,399..401,403..405,428,
                     431..432,434..436,440)
                     /site_type="other"
                     /note="G-alpha interaction site"
                     /db_xref="CDD:188691"
     CDS             1..684
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /coded_by="XM_024449759.2:534..2588"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
ORIGIN      
        1 maqgsgdqra vgvadpeess pnmivyckie diitkmqddk tggvpirtvk sflskipsvv
       61 tgtdivqwlm knlsiedpve aihlgsliaa qgyifpisdh vltmkddgtf yrfqapyfwp
      121 sncwepentd yaiylckrtm qnkarlelad yeaenlarlq rafarkwefi fmqaeaqvki
      181 drkkdkterk ildsqerafw dvhrpvpgcv nttemdirkc rrlknpqkvk ksvygvtees
      241 qaqspvhvls qpirkttked irkqitflna qidrhclkms kvaesliayt eqyveydpli
      301 tpaepsnpwi sddvalwdie mskepsqqrv krwgfsfdei lkdqvgrdqf lrflesefss
      361 enlrfwlavq dlkkqplqdv akrveeiwqe flapgapsai nldshsyeit sqnvkdggry
      421 tfedaqehiy klmksdsyar flrsnayqdl llakkkpese qgrrtslekf trsvnvqntr
      481 pagawsifma alpmavwlrt prschglses rllglpslhd glregkvagg qaphgpdavl
      541 ltvptagpgp gpadptgrrr rstsadrvsl rgdlvtvkek dciptlhslr gpdpssfrge
      601 hvvgflsrls leiillsslp rcletvtpsg kfkrhewtes tssicitsla ppivtattsp
      661 pppviphvsv atrvslpapg taft
//
LOCUS       XP_024305529             684 aa            linear   PRI 05-AUG-2025
DEFINITION  regulator of G-protein signaling 6 isoform X1 [Homo sapiens].
ACCESSION   XP_024305529
VERSION     XP_024305529.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449761.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..684
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..684
                     /product="regulator of G-protein signaling 6 isoform X1"
                     /calculated_mol_wt=76924
     Region          31..119
                     /region_name="DEP_RGS7-like"
                     /note="DEP (Dishevelled, Egl-10, and Pleckstrin) domain
                     found in RGS (regulator of G-protein signaling) proteins
                     of the subfamily R7. This subgroup contains RGS7, RGS6,
                     RGS9 and RGS11. They share a common domain architecture,
                     containing, beside the RGS domain; cd04450"
                     /db_xref="CDD:239897"
     Region          116..217
                     /region_name="RGS_DHEX"
                     /note="Regulator of G-protein signalling DHEX domain;
                     pfam18148"
                     /db_xref="CDD:375589"
     Region          258..319
                     /region_name="GGL"
                     /note="G protein gamma subunit-like motifs; smart00224"
                     /db_xref="CDD:128520"
     Site            order(258,261,265,268,272,277,279,282..283,286..287,290,
                     299..300,309)
                     /site_type="other"
                     /note="beta subunit binding site [polypeptide binding]"
                     /db_xref="CDD:238024"
     Region          328..452
                     /region_name="RGS_RGS6"
                     /note="Regulator of G protein signaling (RGS) domain found
                     in the RGS6 protein; cd08737"
                     /db_xref="CDD:188691"
     Site            order(342,373..377,418..420,423,430,434)
                     /site_type="other"
                     /note="G-beta-5 interaction site"
                     /db_xref="CDD:188691"
     Site            order(357..359,361..362,395..397,399..401,403..405,428,
                     431..432,434..436,440)
                     /site_type="other"
                     /note="G-alpha interaction site"
                     /db_xref="CDD:188691"
     CDS             1..684
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /coded_by="XM_024449761.2:639..2693"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
ORIGIN      
        1 maqgsgdqra vgvadpeess pnmivyckie diitkmqddk tggvpirtvk sflskipsvv
       61 tgtdivqwlm knlsiedpve aihlgsliaa qgyifpisdh vltmkddgtf yrfqapyfwp
      121 sncwepentd yaiylckrtm qnkarlelad yeaenlarlq rafarkwefi fmqaeaqvki
      181 drkkdkterk ildsqerafw dvhrpvpgcv nttemdirkc rrlknpqkvk ksvygvtees
      241 qaqspvhvls qpirkttked irkqitflna qidrhclkms kvaesliayt eqyveydpli
      301 tpaepsnpwi sddvalwdie mskepsqqrv krwgfsfdei lkdqvgrdqf lrflesefss
      361 enlrfwlavq dlkkqplqdv akrveeiwqe flapgapsai nldshsyeit sqnvkdggry
      421 tfedaqehiy klmksdsyar flrsnayqdl llakkkpese qgrrtslekf trsvnvqntr
      481 pagawsifma alpmavwlrt prschglses rllglpslhd glregkvagg qaphgpdavl
      541 ltvptagpgp gpadptgrrr rstsadrvsl rgdlvtvkek dciptlhslr gpdpssfrge
      601 hvvgflsrls leiillsslp rcletvtpsg kfkrhewtes tssicitsla ppivtattsp
      661 pppviphvsv atrvslpapg taft
//
LOCUS       XP_024305528             684 aa            linear   PRI 05-AUG-2025
DEFINITION  regulator of G-protein signaling 6 isoform X1 [Homo sapiens].
ACCESSION   XP_024305528
VERSION     XP_024305528.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449760.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..684
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..684
                     /product="regulator of G-protein signaling 6 isoform X1"
                     /calculated_mol_wt=76924
     Region          31..119
                     /region_name="DEP_RGS7-like"
                     /note="DEP (Dishevelled, Egl-10, and Pleckstrin) domain
                     found in RGS (regulator of G-protein signaling) proteins
                     of the subfamily R7. This subgroup contains RGS7, RGS6,
                     RGS9 and RGS11. They share a common domain architecture,
                     containing, beside the RGS domain; cd04450"
                     /db_xref="CDD:239897"
     Region          116..217
                     /region_name="RGS_DHEX"
                     /note="Regulator of G-protein signalling DHEX domain;
                     pfam18148"
                     /db_xref="CDD:375589"
     Region          258..319
                     /region_name="GGL"
                     /note="G protein gamma subunit-like motifs; smart00224"
                     /db_xref="CDD:128520"
     Site            order(258,261,265,268,272,277,279,282..283,286..287,290,
                     299..300,309)
                     /site_type="other"
                     /note="beta subunit binding site [polypeptide binding]"
                     /db_xref="CDD:238024"
     Region          328..452
                     /region_name="RGS_RGS6"
                     /note="Regulator of G protein signaling (RGS) domain found
                     in the RGS6 protein; cd08737"
                     /db_xref="CDD:188691"
     Site            order(342,373..377,418..420,423,430,434)
                     /site_type="other"
                     /note="G-beta-5 interaction site"
                     /db_xref="CDD:188691"
     Site            order(357..359,361..362,395..397,399..401,403..405,428,
                     431..432,434..436,440)
                     /site_type="other"
                     /note="G-alpha interaction site"
                     /db_xref="CDD:188691"
     CDS             1..684
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /coded_by="XM_024449760.2:255..2309"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
ORIGIN      
        1 maqgsgdqra vgvadpeess pnmivyckie diitkmqddk tggvpirtvk sflskipsvv
       61 tgtdivqwlm knlsiedpve aihlgsliaa qgyifpisdh vltmkddgtf yrfqapyfwp
      121 sncwepentd yaiylckrtm qnkarlelad yeaenlarlq rafarkwefi fmqaeaqvki
      181 drkkdkterk ildsqerafw dvhrpvpgcv nttemdirkc rrlknpqkvk ksvygvtees
      241 qaqspvhvls qpirkttked irkqitflna qidrhclkms kvaesliayt eqyveydpli
      301 tpaepsnpwi sddvalwdie mskepsqqrv krwgfsfdei lkdqvgrdqf lrflesefss
      361 enlrfwlavq dlkkqplqdv akrveeiwqe flapgapsai nldshsyeit sqnvkdggry
      421 tfedaqehiy klmksdsyar flrsnayqdl llakkkpese qgrrtslekf trsvnvqntr
      481 pagawsifma alpmavwlrt prschglses rllglpslhd glregkvagg qaphgpdavl
      541 ltvptagpgp gpadptgrrr rstsadrvsl rgdlvtvkek dciptlhslr gpdpssfrge
      601 hvvgflsrls leiillsslp rcletvtpsg kfkrhewtes tssicitsla ppivtattsp
      661 pppviphvsv atrvslpapg taft
//
LOCUS       XP_016877309             647 aa            linear   PRI 05-AUG-2025
DEFINITION  regulator of G-protein signaling 6 isoform X2 [Homo sapiens].
ACCESSION   XP_016877309
VERSION     XP_016877309.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021820.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..647
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..647
                     /product="regulator of G-protein signaling 6 isoform X2"
                     /calculated_mol_wt=72656
     Region          31..119
                     /region_name="DEP_RGS7-like"
                     /note="DEP (Dishevelled, Egl-10, and Pleckstrin) domain
                     found in RGS (regulator of G-protein signaling) proteins
                     of the subfamily R7. This subgroup contains RGS7, RGS6,
                     RGS9 and RGS11. They share a common domain architecture,
                     containing, beside the RGS domain; cd04450"
                     /db_xref="CDD:239897"
     Region          116..217
                     /region_name="RGS_DHEX"
                     /note="Regulator of G-protein signalling DHEX domain;
                     pfam18148"
                     /db_xref="CDD:375589"
     Region          258..>285
                     /region_name="GGL"
                     /note="G protein gamma subunit-like motifs, the
                     alpha-helical G-gamma chain dimerizes with the G-beta
                     propeller subunit as part of the heterotrimeric G-protein
                     complex; involved in signal transduction via
                     G-protein-coupled receptors; cl00069"
                     /db_xref="CDD:469600"
     Region          291..415
                     /region_name="RGS_RGS6"
                     /note="Regulator of G protein signaling (RGS) domain found
                     in the RGS6 protein; cd08737"
                     /db_xref="CDD:188691"
     Site            order(305,336..340,381..383,386,393,397)
                     /site_type="other"
                     /note="G-beta-5 interaction site"
                     /db_xref="CDD:188691"
     Site            order(320..322,324..325,358..360,362..364,366..368,391,
                     394..395,397..399,403)
                     /site_type="other"
                     /note="G-alpha interaction site"
                     /db_xref="CDD:188691"
     CDS             1..647
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /coded_by="XM_017021820.3:534..2477"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
ORIGIN      
        1 maqgsgdqra vgvadpeess pnmivyckie diitkmqddk tggvpirtvk sflskipsvv
       61 tgtdivqwlm knlsiedpve aihlgsliaa qgyifpisdh vltmkddgtf yrfqapyfwp
      121 sncwepentd yaiylckrtm qnkarlelad yeaenlarlq rafarkwefi fmqaeaqvki
      181 drkkdkterk ildsqerafw dvhrpvpgcv nttemdirkc rrlknpqkvk ksvygvtees
      241 qaqspvhvls qpirkttked irkqitflna qidrhclkms kvaeskepsq qrvkrwgfsf
      301 deilkdqvgr dqflrflese fssenlrfwl avqdlkkqpl qdvakrveei wqeflapgap
      361 sainldshsy eitsqnvkdg grytfedaqe hiyklmksds yarflrsnay qdlllakkkp
      421 eseqgrrtsl ekftrsvnvq ntrpagawsi fmaalpmavw lrtprschgl sesrllglps
      481 lhdglregkv aggqaphgpd avlltvptag pgpgpadptg rrrrstsadr vslrgdlvtv
      541 kekdciptlh slrgpdpssf rgehvvgfls rlsleiills slprcletvt psgkfkrhew
      601 testssicit slappivtat tsppppviph vsvatrvslp apgtaft
//
LOCUS       XP_047287941             624 aa            linear   PRI 05-AUG-2025
DEFINITION  regulator of G-protein signaling 6 isoform X3 [Homo sapiens].
ACCESSION   XP_047287941
VERSION     XP_047287941.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431985.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..624
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..624
                     /product="regulator of G-protein signaling 6 isoform X3"
                     /calculated_mol_wt=70210
     Region          62..157
                     /region_name="RGS_DHEX"
                     /note="Regulator of G-protein signalling DHEX domain;
                     pfam18148"
                     /db_xref="CDD:375589"
     Region          198..259
                     /region_name="GGL"
                     /note="G protein gamma subunit-like motifs; smart00224"
                     /db_xref="CDD:128520"
     Site            order(198,201,205,208,212,217,219,222..223,226..227,230,
                     239..240,249)
                     /site_type="other"
                     /note="beta subunit binding site [polypeptide binding]"
                     /db_xref="CDD:238024"
     Region          268..392
                     /region_name="RGS_RGS6"
                     /note="Regulator of G protein signaling (RGS) domain found
                     in the RGS6 protein; cd08737"
                     /db_xref="CDD:188691"
     Site            order(282,313..317,358..360,363,370,374)
                     /site_type="other"
                     /note="G-beta-5 interaction site"
                     /db_xref="CDD:188691"
     Site            order(297..299,301..302,335..337,339..341,343..345,368,
                     371..372,374..376,380)
                     /site_type="other"
                     /note="G-alpha interaction site"
                     /db_xref="CDD:188691"
     CDS             1..624
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /coded_by="XM_047431985.1:133..2007"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
ORIGIN      
        1 mmapfivsrl rtsglrtagn lktltmrkaq ltercspwrg srrgkknlik ggqyvhlgam
       61 enqdptatls daiylckrtm qnkarlelad yeaenlarlq rafarkwefi fmqaeaqvki
      121 drkkdkterk ildsqerafw dvhrpvpgcv nttemdirkc rrlknpqkvk ksvygvtees
      181 qaqspvhvls qpirkttked irkqitflna qidrhclkms kvaesliayt eqyveydpli
      241 tpaepsnpwi sddvalwdie mskepsqqrv krwgfsfdei lkdqvgrdqf lrflesefss
      301 enlrfwlavq dlkkqplqdv akrveeiwqe flapgapsai nldshsyeit sqnvkdggry
      361 tfedaqehiy klmksdsyar flrsnayqdl llakkkpese qgrrtslekf trsvnvqntr
      421 pagawsifma alpmavwlrt prschglses rllglpslhd glregkvagg qaphgpdavl
      481 ltvptagpgp gpadptgrrr rstsadrvsl rgdlvtvkek dciptlhslr gpdpssfrge
      541 hvvgflsrls leiillsslp rcletvtpsg kfkrhewtes tssicitsla ppivtattsp
      601 pppviphvsv atrvslpapg taft
//
LOCUS       XP_024305531             615 aa            linear   PRI 05-AUG-2025
DEFINITION  regulator of G-protein signaling 6 isoform X4 [Homo sapiens].
ACCESSION   XP_024305531
VERSION     XP_024305531.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449763.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..615
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..615
                     /product="regulator of G-protein signaling 6 isoform X4"
                     /calculated_mol_wt=69490
     Region          <1..50
                     /region_name="DEP_RGS7-like"
                     /note="DEP (Dishevelled, Egl-10, and Pleckstrin) domain
                     found in RGS (regulator of G-protein signaling) proteins
                     of the subfamily R7. This subgroup contains RGS7, RGS6,
                     RGS9 and RGS11. They share a common domain architecture,
                     containing, beside the RGS domain; cd04450"
                     /db_xref="CDD:239897"
     Region          47..148
                     /region_name="RGS_DHEX"
                     /note="Regulator of G-protein signalling DHEX domain;
                     pfam18148"
                     /db_xref="CDD:375589"
     Region          189..250
                     /region_name="GGL"
                     /note="G protein gamma subunit-like motifs; smart00224"
                     /db_xref="CDD:128520"
     Site            order(189,192,196,199,203,208,210,213..214,217..218,221,
                     230..231,240)
                     /site_type="other"
                     /note="beta subunit binding site [polypeptide binding]"
                     /db_xref="CDD:238024"
     Region          259..383
                     /region_name="RGS_RGS6"
                     /note="Regulator of G protein signaling (RGS) domain found
                     in the RGS6 protein; cd08737"
                     /db_xref="CDD:188691"
     Site            order(273,304..308,349..351,354,361,365)
                     /site_type="other"
                     /note="G-beta-5 interaction site"
                     /db_xref="CDD:188691"
     Site            order(288..290,292..293,326..328,330..332,334..336,359,
                     362..363,365..367,371)
                     /site_type="other"
                     /note="G-alpha interaction site"
                     /db_xref="CDD:188691"
     CDS             1..615
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /coded_by="XM_024449763.2:444..2291"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
ORIGIN      
        1 mknlsiedpv eaihlgslia aqgyifpisd hvltmkddgt fyrfqapyfw psncwepent
       61 dyaiylckrt mqnkarlela dyeaenlarl qrafarkwef ifmqaeaqvk idrkkdkter
      121 kildsqeraf wdvhrpvpgc vnttemdirk crrlknpqkv kksvygvtee sqaqspvhvl
      181 sqpirkttke dirkqitfln aqidrhclkm skvaesliay teqyveydpl itpaepsnpw
      241 isddvalwdi emskepsqqr vkrwgfsfde ilkdqvgrdq flrflesefs senlrfwlav
      301 qdlkkqplqd vakrveeiwq eflapgapsa inldshsyei tsqnvkdggr ytfedaqehi
      361 yklmksdsya rflrsnayqd lllakkkpes eqgrrtslek ftrsvnvqnt rpagawsifm
      421 aalpmavwlr tprschglse srllglpslh dglregkvag gqaphgpdav lltvptagpg
      481 pgpadptgrr rrstsadrvs lrgdlvtvke kdciptlhsl rgpdpssfrg ehvvgflsrl
      541 sleiillssl prcletvtps gkfkrhewte stssicitsl appivtatts ppppviphvs
      601 vatrvslpap gtaft
//
LOCUS       XP_024305532             615 aa            linear   PRI 05-AUG-2025
DEFINITION  regulator of G-protein signaling 6 isoform X4 [Homo sapiens].
ACCESSION   XP_024305532
VERSION     XP_024305532.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449764.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..615
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..615
                     /product="regulator of G-protein signaling 6 isoform X4"
                     /calculated_mol_wt=69490
     Region          <1..50
                     /region_name="DEP_RGS7-like"
                     /note="DEP (Dishevelled, Egl-10, and Pleckstrin) domain
                     found in RGS (regulator of G-protein signaling) proteins
                     of the subfamily R7. This subgroup contains RGS7, RGS6,
                     RGS9 and RGS11. They share a common domain architecture,
                     containing, beside the RGS domain; cd04450"
                     /db_xref="CDD:239897"
     Region          47..148
                     /region_name="RGS_DHEX"
                     /note="Regulator of G-protein signalling DHEX domain;
                     pfam18148"
                     /db_xref="CDD:375589"
     Region          189..250
                     /region_name="GGL"
                     /note="G protein gamma subunit-like motifs; smart00224"
                     /db_xref="CDD:128520"
     Site            order(189,192,196,199,203,208,210,213..214,217..218,221,
                     230..231,240)
                     /site_type="other"
                     /note="beta subunit binding site [polypeptide binding]"
                     /db_xref="CDD:238024"
     Region          259..383
                     /region_name="RGS_RGS6"
                     /note="Regulator of G protein signaling (RGS) domain found
                     in the RGS6 protein; cd08737"
                     /db_xref="CDD:188691"
     Site            order(273,304..308,349..351,354,361,365)
                     /site_type="other"
                     /note="G-beta-5 interaction site"
                     /db_xref="CDD:188691"
     Site            order(288..290,292..293,326..328,330..332,334..336,359,
                     362..363,365..367,371)
                     /site_type="other"
                     /note="G-alpha interaction site"
                     /db_xref="CDD:188691"
     CDS             1..615
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /coded_by="XM_024449764.2:726..2573"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
ORIGIN      
        1 mknlsiedpv eaihlgslia aqgyifpisd hvltmkddgt fyrfqapyfw psncwepent
       61 dyaiylckrt mqnkarlela dyeaenlarl qrafarkwef ifmqaeaqvk idrkkdkter
      121 kildsqeraf wdvhrpvpgc vnttemdirk crrlknpqkv kksvygvtee sqaqspvhvl
      181 sqpirkttke dirkqitfln aqidrhclkm skvaesliay teqyveydpl itpaepsnpw
      241 isddvalwdi emskepsqqr vkrwgfsfde ilkdqvgrdq flrflesefs senlrfwlav
      301 qdlkkqplqd vakrveeiwq eflapgapsa inldshsyei tsqnvkdggr ytfedaqehi
      361 yklmksdsya rflrsnayqd lllakkkpes eqgrrtslek ftrsvnvqnt rpagawsifm
      421 aalpmavwlr tprschglse srllglpslh dglregkvag gqaphgpdav lltvptagpg
      481 pgpadptgrr rrstsadrvs lrgdlvtvke kdciptlhsl rgpdpssfrg ehvvgflsrl
      541 sleiillssl prcletvtps gkfkrhewte stssicitsl appivtatts ppppviphvs
      601 vatrvslpap gtaft
//
LOCUS       XP_011535699             545 aa            linear   PRI 05-AUG-2025
DEFINITION  regulator of G-protein signaling 6 isoform X5 [Homo sapiens].
ACCESSION   XP_011535699
VERSION     XP_011535699.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537397.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..545
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..545
                     /product="regulator of G-protein signaling 6 isoform X5"
                     /calculated_mol_wt=61374
     Region          <1..78
                     /region_name="RGS_DHEX"
                     /note="Regulator of G-protein signalling DHEX domain;
                     pfam18148"
                     /db_xref="CDD:375589"
     Region          119..180
                     /region_name="GGL"
                     /note="G protein gamma subunit-like motifs; smart00224"
                     /db_xref="CDD:128520"
     Site            order(119,122,126,129,133,138,140,143..144,147..148,151,
                     160..161,170)
                     /site_type="other"
                     /note="beta subunit binding site [polypeptide binding]"
                     /db_xref="CDD:238024"
     Region          189..313
                     /region_name="RGS_RGS6"
                     /note="Regulator of G protein signaling (RGS) domain found
                     in the RGS6 protein; cd08737"
                     /db_xref="CDD:188691"
     Site            order(203,234..238,279..281,284,291,295)
                     /site_type="other"
                     /note="G-beta-5 interaction site"
                     /db_xref="CDD:188691"
     Site            order(218..220,222..223,256..258,260..262,264..266,289,
                     292..293,295..297,301)
                     /site_type="other"
                     /note="G-alpha interaction site"
                     /db_xref="CDD:188691"
     CDS             1..545
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /coded_by="XM_011537397.2:115..1752"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
ORIGIN      
        1 mqnkarlela dyeaenlarl qrafarkwef ifmqaeaqvk idrkkdkter kildsqeraf
       61 wdvhrpvpgc vnttemdirk crrlknpqkv kksvygvtee sqaqspvhvl sqpirkttke
      121 dirkqitfln aqidrhclkm skvaesliay teqyveydpl itpaepsnpw isddvalwdi
      181 emskepsqqr vkrwgfsfde ilkdqvgrdq flrflesefs senlrfwlav qdlkkqplqd
      241 vakrveeiwq eflapgapsa inldshsyei tsqnvkdggr ytfedaqehi yklmksdsya
      301 rflrsnayqd lllakkkpes eqgrrtslek ftrsvnvqnt rpagawsifm aalpmavwlr
      361 tprschglse srllglpslh dglregkvag gqaphgpdav lltvptagpg pgpadptgrr
      421 rrstsadrvs lrgdlvtvke kdciptlhsl rgpdpssfrg ehvvgflsrl sleiillssl
      481 prcletvtps gkfkrhewte stssicitsl appivtatts ppppviphvs vatrvslpap
      541 gtaft
//
LOCUS       XP_016877311             522 aa            linear   PRI 05-AUG-2025
DEFINITION  regulator of G-protein signaling 6 isoform X6 [Homo sapiens].
ACCESSION   XP_016877311
VERSION     XP_016877311.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021822.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..522
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..522
                     /product="regulator of G-protein signaling 6 isoform X6"
                     /calculated_mol_wt=60032
     Region          31..119
                     /region_name="DEP_RGS7-like"
                     /note="DEP (Dishevelled, Egl-10, and Pleckstrin) domain
                     found in RGS (regulator of G-protein signaling) proteins
                     of the subfamily R7. This subgroup contains RGS7, RGS6,
                     RGS9 and RGS11. They share a common domain architecture,
                     containing, beside the RGS domain; cd04450"
                     /db_xref="CDD:239897"
     Region          116..217
                     /region_name="RGS_DHEX"
                     /note="Regulator of G-protein signalling DHEX domain;
                     pfam18148"
                     /db_xref="CDD:375589"
     Region          258..319
                     /region_name="GGL"
                     /note="G protein gamma subunit-like motifs; smart00224"
                     /db_xref="CDD:128520"
     Site            order(258,261,265,268,272,277,279,282..283,286..287,290,
                     299..300,309)
                     /site_type="other"
                     /note="beta subunit binding site [polypeptide binding]"
                     /db_xref="CDD:238024"
     Region          328..452
                     /region_name="RGS_RGS6"
                     /note="Regulator of G protein signaling (RGS) domain found
                     in the RGS6 protein; cd08737"
                     /db_xref="CDD:188691"
     Site            order(342,373..377,418..420,423,430,434)
                     /site_type="other"
                     /note="G-beta-5 interaction site"
                     /db_xref="CDD:188691"
     Site            order(357..359,361..362,395..397,399..401,403..405,428,
                     431..432,434..436,440)
                     /site_type="other"
                     /note="G-alpha interaction site"
                     /db_xref="CDD:188691"
     CDS             1..522
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /coded_by="XM_017021822.3:534..2102"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
ORIGIN      
        1 maqgsgdqra vgvadpeess pnmivyckie diitkmqddk tggvpirtvk sflskipsvv
       61 tgtdivqwlm knlsiedpve aihlgsliaa qgyifpisdh vltmkddgtf yrfqapyfwp
      121 sncwepentd yaiylckrtm qnkarlelad yeaenlarlq rafarkwefi fmqaeaqvki
      181 drkkdkterk ildsqerafw dvhrpvpgcv nttemdirkc rrlknpqkvk ksvygvtees
      241 qaqspvhvls qpirkttked irkqitflna qidrhclkms kvaesliayt eqyveydpli
      301 tpaepsnpwi sddvalwdie mskepsqqrv krwgfsfdei lkdqvgrdqf lrflesefss
      361 enlrfwlavq dlkkqplqdv akrveeiwqe flapgapsai nldshsyeit sqnvkdggry
      421 tfedaqehiy klmksdsyar flrsnayqdl llakkkpese qgrrtslekf trsvanyips
      481 splplklipa ptttaqqgll haiqpssiyf phcsqnhqkf qv
//
LOCUS       XP_047287943             521 aa            linear   PRI 05-AUG-2025
DEFINITION  regulator of G-protein signaling 6 isoform X7 [Homo sapiens].
ACCESSION   XP_047287943
VERSION     XP_047287943.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431987.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..521
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..521
                     /product="regulator of G-protein signaling 6 isoform X7"
                     /calculated_mol_wt=59775
     Region          31..119
                     /region_name="DEP_RGS7-like"
                     /note="DEP (Dishevelled, Egl-10, and Pleckstrin) domain
                     found in RGS (regulator of G-protein signaling) proteins
                     of the subfamily R7. This subgroup contains RGS7, RGS6,
                     RGS9 and RGS11. They share a common domain architecture,
                     containing, beside the RGS domain; cd04450"
                     /db_xref="CDD:239897"
     Region          116..217
                     /region_name="RGS_DHEX"
                     /note="Regulator of G-protein signalling DHEX domain;
                     pfam18148"
                     /db_xref="CDD:375589"
     Region          258..319
                     /region_name="GGL"
                     /note="G protein gamma subunit-like motifs; smart00224"
                     /db_xref="CDD:128520"
     Site            order(258,261,265,268,272,277,279,282..283,286..287,290,
                     299..300,309)
                     /site_type="other"
                     /note="beta subunit binding site [polypeptide binding]"
                     /db_xref="CDD:238024"
     Region          328..452
                     /region_name="RGS_RGS6"
                     /note="Regulator of G protein signaling (RGS) domain found
                     in the RGS6 protein; cd08737"
                     /db_xref="CDD:188691"
     Site            order(342,373..377,418..420,423,430,434)
                     /site_type="other"
                     /note="G-beta-5 interaction site"
                     /db_xref="CDD:188691"
     Site            order(357..359,361..362,395..397,399..401,403..405,428,
                     431..432,434..436,440)
                     /site_type="other"
                     /note="G-alpha interaction site"
                     /db_xref="CDD:188691"
     CDS             1..521
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /coded_by="XM_047431987.1:534..2099"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
ORIGIN      
        1 maqgsgdqra vgvadpeess pnmivyckie diitkmqddk tggvpirtvk sflskipsvv
       61 tgtdivqwlm knlsiedpve aihlgsliaa qgyifpisdh vltmkddgtf yrfqapyfwp
      121 sncwepentd yaiylckrtm qnkarlelad yeaenlarlq rafarkwefi fmqaeaqvki
      181 drkkdkterk ildsqerafw dvhrpvpgcv nttemdirkc rrlknpqkvk ksvygvtees
      241 qaqspvhvls qpirkttked irkqitflna qidrhclkms kvaesliayt eqyveydpli
      301 tpaepsnpwi sddvalwdie mskepsqqrv krwgfsfdei lkdqvgrdqf lrflesefss
      361 enlrfwlavq dlkkqplqdv akrveeiwqe flapgapsai nldshsyeit sqnvkdggry
      421 tfedaqehiy klmksdsyar flrsnayqdl llakkkpese qgrrtslekf trsvksecae
      481 hkacgclvyl hgcfangrva phtkklprav rvkasgtsft p
//
LOCUS       XP_016877314             476 aa            linear   PRI 05-AUG-2025
DEFINITION  regulator of G-protein signaling 6 isoform X8 [Homo sapiens].
ACCESSION   XP_016877314
VERSION     XP_016877314.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021825.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..476
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..476
                     /product="regulator of G-protein signaling 6 isoform X8"
                     /calculated_mol_wt=54993
     Region          31..119
                     /region_name="DEP_RGS7-like"
                     /note="DEP (Dishevelled, Egl-10, and Pleckstrin) domain
                     found in RGS (regulator of G-protein signaling) proteins
                     of the subfamily R7. This subgroup contains RGS7, RGS6,
                     RGS9 and RGS11. They share a common domain architecture,
                     containing, beside the RGS domain; cd04450"
                     /db_xref="CDD:239897"
     Region          116..217
                     /region_name="RGS_DHEX"
                     /note="Regulator of G-protein signalling DHEX domain;
                     pfam18148"
                     /db_xref="CDD:375589"
     Region          258..319
                     /region_name="GGL"
                     /note="G protein gamma subunit-like motifs; smart00224"
                     /db_xref="CDD:128520"
     Site            order(258,261,265,268,272,277,279,282..283,286..287,290,
                     299..300,309)
                     /site_type="other"
                     /note="beta subunit binding site [polypeptide binding]"
                     /db_xref="CDD:238024"
     Region          328..452
                     /region_name="RGS_RGS6"
                     /note="Regulator of G protein signaling (RGS) domain found
                     in the RGS6 protein; cd08737"
                     /db_xref="CDD:188691"
     Site            order(342,373..377,418..420,423,430,434)
                     /site_type="other"
                     /note="G-beta-5 interaction site"
                     /db_xref="CDD:188691"
     Site            order(357..359,361..362,395..397,399..401,403..405,428,
                     431..432,434..436,440)
                     /site_type="other"
                     /note="G-alpha interaction site"
                     /db_xref="CDD:188691"
     CDS             1..476
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /coded_by="XM_017021825.3:534..1964"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
ORIGIN      
        1 maqgsgdqra vgvadpeess pnmivyckie diitkmqddk tggvpirtvk sflskipsvv
       61 tgtdivqwlm knlsiedpve aihlgsliaa qgyifpisdh vltmkddgtf yrfqapyfwp
      121 sncwepentd yaiylckrtm qnkarlelad yeaenlarlq rafarkwefi fmqaeaqvki
      181 drkkdkterk ildsqerafw dvhrpvpgcv nttemdirkc rrlknpqkvk ksvygvtees
      241 qaqspvhvls qpirkttked irkqitflna qidrhclkms kvaesliayt eqyveydpli
      301 tpaepsnpwi sddvalwdie mskepsqqrv krwgfsfdei lkdqvgrdqf lrflesefss
      361 enlrfwlavq dlkkqplqdv akrveeiwqe flapgapsai nldshsyeit sqnvkdggry
      421 tfedaqehiy klmksdsyar flrsnayqdl llakkkpese qgrrtslekf trsvqv
//
LOCUS       XP_016877315             475 aa            linear   PRI 05-AUG-2025
DEFINITION  regulator of G-protein signaling 6 isoform X9 [Homo sapiens].
ACCESSION   XP_016877315
VERSION     XP_016877315.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021826.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..475
                     /product="regulator of G-protein signaling 6 isoform X9"
                     /calculated_mol_wt=54823
     Region          31..119
                     /region_name="DEP_RGS7-like"
                     /note="DEP (Dishevelled, Egl-10, and Pleckstrin) domain
                     found in RGS (regulator of G-protein signaling) proteins
                     of the subfamily R7. This subgroup contains RGS7, RGS6,
                     RGS9 and RGS11. They share a common domain architecture,
                     containing, beside the RGS domain; cd04450"
                     /db_xref="CDD:239897"
     Region          116..217
                     /region_name="RGS_DHEX"
                     /note="Regulator of G-protein signalling DHEX domain;
                     pfam18148"
                     /db_xref="CDD:375589"
     Region          258..319
                     /region_name="GGL"
                     /note="G protein gamma subunit-like motifs; smart00224"
                     /db_xref="CDD:128520"
     Site            order(258,261,265,268,272,277,279,282..283,286..287,290,
                     299..300,309)
                     /site_type="other"
                     /note="beta subunit binding site [polypeptide binding]"
                     /db_xref="CDD:238024"
     Region          328..452
                     /region_name="RGS_RGS6"
                     /note="Regulator of G protein signaling (RGS) domain found
                     in the RGS6 protein; cd08737"
                     /db_xref="CDD:188691"
     Site            order(342,373..377,418..420,423,430,434)
                     /site_type="other"
                     /note="G-beta-5 interaction site"
                     /db_xref="CDD:188691"
     Site            order(357..359,361..362,395..397,399..401,403..405,428,
                     431..432,434..436,440)
                     /site_type="other"
                     /note="G-alpha interaction site"
                     /db_xref="CDD:188691"
     CDS             1..475
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /coded_by="XM_017021826.3:534..1961"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
ORIGIN      
        1 maqgsgdqra vgvadpeess pnmivyckie diitkmqddk tggvpirtvk sflskipsvv
       61 tgtdivqwlm knlsiedpve aihlgsliaa qgyifpisdh vltmkddgtf yrfqapyfwp
      121 sncwepentd yaiylckrtm qnkarlelad yeaenlarlq rafarkwefi fmqaeaqvki
      181 drkkdkterk ildsqerafw dvhrpvpgcv nttemdirkc rrlknpqkvk ksvygvtees
      241 qaqspvhvls qpirkttked irkqitflna qidrhclkms kvaesliayt eqyveydpli
      301 tpaepsnpwi sddvalwdie mskepsqqrv krwgfsfdei lkdqvgrdqf lrflesefss
      361 enlrfwlavq dlkkqplqdv akrveeiwqe flapgapsai nldshsyeit sqnvkdggry
      421 tfedaqehiy klmksdsyar flrsnayqdl llakkkpese qgrrtslekf trsvg
//
LOCUS       XP_016877316             475 aa            linear   PRI 05-AUG-2025
DEFINITION  regulator of G-protein signaling 6 isoform X10 [Homo sapiens].
ACCESSION   XP_016877316
VERSION     XP_016877316.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021827.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..475
                     /product="regulator of G-protein signaling 6 isoform X10"
                     /calculated_mol_wt=54879
     Region          31..119
                     /region_name="DEP_RGS7-like"
                     /note="DEP (Dishevelled, Egl-10, and Pleckstrin) domain
                     found in RGS (regulator of G-protein signaling) proteins
                     of the subfamily R7. This subgroup contains RGS7, RGS6,
                     RGS9 and RGS11. They share a common domain architecture,
                     containing, beside the RGS domain; cd04450"
                     /db_xref="CDD:239897"
     Region          116..217
                     /region_name="RGS_DHEX"
                     /note="Regulator of G-protein signalling DHEX domain;
                     pfam18148"
                     /db_xref="CDD:375589"
     Region          258..319
                     /region_name="GGL"
                     /note="G protein gamma subunit-like motifs; smart00224"
                     /db_xref="CDD:128520"
     Site            order(258,261,265,268,272,277,279,282..283,286..287,290,
                     299..300,309)
                     /site_type="other"
                     /note="beta subunit binding site [polypeptide binding]"
                     /db_xref="CDD:238024"
     Region          328..452
                     /region_name="RGS_RGS6"
                     /note="Regulator of G protein signaling (RGS) domain found
                     in the RGS6 protein; cd08737"
                     /db_xref="CDD:188691"
     Site            order(342,373..377,418..420,423,430,434)
                     /site_type="other"
                     /note="G-beta-5 interaction site"
                     /db_xref="CDD:188691"
     Site            order(357..359,361..362,395..397,399..401,403..405,428,
                     431..432,434..436,440)
                     /site_type="other"
                     /note="G-alpha interaction site"
                     /db_xref="CDD:188691"
     CDS             1..475
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /coded_by="XM_017021827.3:534..1961"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
ORIGIN      
        1 maqgsgdqra vgvadpeess pnmivyckie diitkmqddk tggvpirtvk sflskipsvv
       61 tgtdivqwlm knlsiedpve aihlgsliaa qgyifpisdh vltmkddgtf yrfqapyfwp
      121 sncwepentd yaiylckrtm qnkarlelad yeaenlarlq rafarkwefi fmqaeaqvki
      181 drkkdkterk ildsqerafw dvhrpvpgcv nttemdirkc rrlknpqkvk ksvygvtees
      241 qaqspvhvls qpirkttked irkqitflna qidrhclkms kvaesliayt eqyveydpli
      301 tpaepsnpwi sddvalwdie mskepsqqrv krwgfsfdei lkdqvgrdqf lrflesefss
      361 enlrfwlavq dlkkqplqdv akrveeiwqe flapgapsai nldshsyeit sqnvkdggry
      421 tfedaqehiy klmksdsyar flrsnayqdl llakkkpese qgrrtslekf trsvi
//
LOCUS       XP_047287944             470 aa            linear   PRI 05-AUG-2025
DEFINITION  regulator of G-protein signaling 6 isoform X11 [Homo sapiens].
ACCESSION   XP_047287944
VERSION     XP_047287944.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431988.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..470
                     /product="regulator of G-protein signaling 6 isoform X11"
                     /calculated_mol_wt=52426
     Region          44..105
                     /region_name="GGL"
                     /note="G protein gamma subunit-like motifs; smart00224"
                     /db_xref="CDD:128520"
     Site            order(44,47,51,54,58,63,65,68..69,72..73,76,85..86,95)
                     /site_type="other"
                     /note="beta subunit binding site [polypeptide binding]"
                     /db_xref="CDD:238024"
     Region          114..238
                     /region_name="RGS_RGS6"
                     /note="Regulator of G protein signaling (RGS) domain found
                     in the RGS6 protein; cd08737"
                     /db_xref="CDD:188691"
     Site            order(128,159..163,204..206,209,216,220)
                     /site_type="other"
                     /note="G-beta-5 interaction site"
                     /db_xref="CDD:188691"
     Site            order(143..145,147..148,181..183,185..187,189..191,214,
                     217..218,220..222,226)
                     /site_type="other"
                     /note="G-alpha interaction site"
                     /db_xref="CDD:188691"
     CDS             1..470
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /coded_by="XM_047431988.1:149..1561"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
ORIGIN      
        1 mdirkcrrlk npqkvkksvy gvteesqaqs pvhvlsqpir kttkedirkq itflnaqidr
       61 hclkmskvae sliayteqyv eydplitpae psnpwisddv alwdiemske psqqrvkrwg
      121 fsfdeilkdq vgrdqflrfl esefssenlr fwlavqdlkk qplqdvakrv eeiwqeflap
      181 gapsainlds hsyeitsqnv kdggrytfed aqehiyklmk sdsyarflrs nayqdlllak
      241 kkpeseqgrr tslekftrsv nvqntrpaga wsifmaalpm avwlrtprsc hglsesrllg
      301 lpslhdglre gkvaggqaph gpdavlltvp tagpgpgpad ptgrrrrsts adrvslrgdl
      361 vtvkekdcip tlhslrgpdp ssfrgehvvg flsrlsleii llsslprcle tvtpsgkfkr
      421 hewtestssi citslappiv tattsppppv iphvsvatrv slpapgtaft
//
LOCUS       XP_016877317             468 aa            linear   PRI 05-AUG-2025
DEFINITION  regulator of G-protein signaling 6 isoform X12 [Homo sapiens].
ACCESSION   XP_016877317
VERSION     XP_016877317.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021828.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..468
                     /product="regulator of G-protein signaling 6 isoform X12"
                     /calculated_mol_wt=54052
     Region          31..119
                     /region_name="DEP_RGS7-like"
                     /note="DEP (Dishevelled, Egl-10, and Pleckstrin) domain
                     found in RGS (regulator of G-protein signaling) proteins
                     of the subfamily R7. This subgroup contains RGS7, RGS6,
                     RGS9 and RGS11. They share a common domain architecture,
                     containing, beside the RGS domain; cd04450"
                     /db_xref="CDD:239897"
     Region          116..217
                     /region_name="RGS_DHEX"
                     /note="Regulator of G-protein signalling DHEX domain;
                     pfam18148"
                     /db_xref="CDD:375589"
     Region          258..319
                     /region_name="GGL"
                     /note="G protein gamma subunit-like motifs; smart00224"
                     /db_xref="CDD:128520"
     Site            order(258,261,265,268,272,277,279,282..283,286..287,290,
                     299..300,309)
                     /site_type="other"
                     /note="beta subunit binding site [polypeptide binding]"
                     /db_xref="CDD:238024"
     Region          328..452
                     /region_name="RGS_RGS6"
                     /note="Regulator of G protein signaling (RGS) domain found
                     in the RGS6 protein; cd08737"
                     /db_xref="CDD:188691"
     Site            order(342,373..377,418..420,423,430,434)
                     /site_type="other"
                     /note="G-beta-5 interaction site"
                     /db_xref="CDD:188691"
     Site            order(357..359,361..362,395..397,399..401,403..405,428,
                     431..432,434..436,440)
                     /site_type="other"
                     /note="G-alpha interaction site"
                     /db_xref="CDD:188691"
     CDS             1..468
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /coded_by="XM_017021828.3:534..1940"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
ORIGIN      
        1 maqgsgdqra vgvadpeess pnmivyckie diitkmqddk tggvpirtvk sflskipsvv
       61 tgtdivqwlm knlsiedpve aihlgsliaa qgyifpisdh vltmkddgtf yrfqapyfwp
      121 sncwepentd yaiylckrtm qnkarlelad yeaenlarlq rafarkwefi fmqaeaqvki
      181 drkkdkterk ildsqerafw dvhrpvpgcv nttemdirkc rrlknpqkvk ksvygvtees
      241 qaqspvhvls qpirkttked irkqitflna qidrhclkms kvaesliayt eqyveydpli
      301 tpaepsnpwi sddvalwdie mskepsqqrv krwgfsfdei lkdqvgrdqf lrflesefss
      361 enlrfwlavq dlkkqplqdv akrveeiwqe flapgapsai nldshsyeit sqnvkdggry
      421 tfedaqehiy klmksdsyar flrsnayqdl llakkkgrvh riqvikgm
//
LOCUS       XP_016877319             465 aa            linear   PRI 05-AUG-2025
DEFINITION  regulator of G-protein signaling 6 isoform X13 [Homo sapiens].
ACCESSION   XP_016877319
VERSION     XP_016877319.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021830.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..465
                     /product="regulator of G-protein signaling 6 isoform X13"
                     /calculated_mol_wt=53656
     Region          31..119
                     /region_name="DEP_RGS7-like"
                     /note="DEP (Dishevelled, Egl-10, and Pleckstrin) domain
                     found in RGS (regulator of G-protein signaling) proteins
                     of the subfamily R7. This subgroup contains RGS7, RGS6,
                     RGS9 and RGS11. They share a common domain architecture,
                     containing, beside the RGS domain; cd04450"
                     /db_xref="CDD:239897"
     Region          116..217
                     /region_name="RGS_DHEX"
                     /note="Regulator of G-protein signalling DHEX domain;
                     pfam18148"
                     /db_xref="CDD:375589"
     Region          258..319
                     /region_name="GGL"
                     /note="G protein gamma subunit-like motifs; smart00224"
                     /db_xref="CDD:128520"
     Site            order(258,261,265,268,272,277,279,282..283,286..287,290,
                     299..300,309)
                     /site_type="other"
                     /note="beta subunit binding site [polypeptide binding]"
                     /db_xref="CDD:238024"
     Region          328..452
                     /region_name="RGS_RGS6"
                     /note="Regulator of G protein signaling (RGS) domain found
                     in the RGS6 protein; cd08737"
                     /db_xref="CDD:188691"
     Site            order(342,373..377,418..420,423,430,434)
                     /site_type="other"
                     /note="G-beta-5 interaction site"
                     /db_xref="CDD:188691"
     Site            order(357..359,361..362,395..397,399..401,403..405,428,
                     431..432,434..436,440)
                     /site_type="other"
                     /note="G-alpha interaction site"
                     /db_xref="CDD:188691"
     CDS             1..465
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /coded_by="XM_017021830.3:534..1931"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
ORIGIN      
        1 maqgsgdqra vgvadpeess pnmivyckie diitkmqddk tggvpirtvk sflskipsvv
       61 tgtdivqwlm knlsiedpve aihlgsliaa qgyifpisdh vltmkddgtf yrfqapyfwp
      121 sncwepentd yaiylckrtm qnkarlelad yeaenlarlq rafarkwefi fmqaeaqvki
      181 drkkdkterk ildsqerafw dvhrpvpgcv nttemdirkc rrlknpqkvk ksvygvtees
      241 qaqspvhvls qpirkttked irkqitflna qidrhclkms kvaesliayt eqyveydpli
      301 tpaepsnpwi sddvalwdie mskepsqqrv krwgfsfdei lkdqvgrdqf lrflesefss
      361 enlrfwlavq dlkkqplqdv akrveeiwqe flapgapsai nldshsyeit sqnvkdggry
      421 tfedaqehiy klmksdsyar flrsnayqdl llakkkkvsk vvelp
//
LOCUS       XP_016877320             462 aa            linear   PRI 05-AUG-2025
DEFINITION  regulator of G-protein signaling 6 isoform X14 [Homo sapiens].
ACCESSION   XP_016877320
VERSION     XP_016877320.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021831.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..462
                     /product="regulator of G-protein signaling 6 isoform X14"
                     /calculated_mol_wt=53170
     Region          31..119
                     /region_name="DEP_RGS7-like"
                     /note="DEP (Dishevelled, Egl-10, and Pleckstrin) domain
                     found in RGS (regulator of G-protein signaling) proteins
                     of the subfamily R7. This subgroup contains RGS7, RGS6,
                     RGS9 and RGS11. They share a common domain architecture,
                     containing, beside the RGS domain; cd04450"
                     /db_xref="CDD:239897"
     Region          116..217
                     /region_name="RGS_DHEX"
                     /note="Regulator of G-protein signalling DHEX domain;
                     pfam18148"
                     /db_xref="CDD:375589"
     Region          258..319
                     /region_name="GGL"
                     /note="G protein gamma subunit-like motifs; smart00224"
                     /db_xref="CDD:128520"
     Site            order(258,261,265,268,272,277,279,282..283,286..287,290,
                     299..300,309)
                     /site_type="other"
                     /note="beta subunit binding site [polypeptide binding]"
                     /db_xref="CDD:238024"
     Region          328..>426
                     /region_name="RGS"
                     /note="Regulator of G protein signaling (RGS) domain
                     superfamily; cl02565"
                     /db_xref="CDD:470619"
     CDS             1..462
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /coded_by="XM_017021831.3:534..1922"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
ORIGIN      
        1 maqgsgdqra vgvadpeess pnmivyckie diitkmqddk tggvpirtvk sflskipsvv
       61 tgtdivqwlm knlsiedpve aihlgsliaa qgyifpisdh vltmkddgtf yrfqapyfwp
      121 sncwepentd yaiylckrtm qnkarlelad yeaenlarlq rafarkwefi fmqaeaqvki
      181 drkkdkterk ildsqerafw dvhrpvpgcv nttemdirkc rrlknpqkvk ksvygvtees
      241 qaqspvhvls qpirkttked irkqitflna qidrhclkms kvaesliayt eqyveydpli
      301 tpaepsnpwi sddvalwdie mskepsqqrv krwgfsfdei lkdqvgrdqf lrflesefss
      361 enlrfwlavq dlkkqplqdv akrveeiwqe flapgapsai nldshsyeit sqnvkdggry
      421 tfedaqilic dplqvlttvl scknraeekl ifprlqltmp kv
//
LOCUS       XP_016877321             460 aa            linear   PRI 05-AUG-2025
DEFINITION  regulator of G-protein signaling 6 isoform X15 [Homo sapiens].
ACCESSION   XP_016877321
VERSION     XP_016877321.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021832.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..460
                     /product="regulator of G-protein signaling 6 isoform X15"
                     /calculated_mol_wt=53188
     Region          31..119
                     /region_name="DEP_RGS7-like"
                     /note="DEP (Dishevelled, Egl-10, and Pleckstrin) domain
                     found in RGS (regulator of G-protein signaling) proteins
                     of the subfamily R7. This subgroup contains RGS7, RGS6,
                     RGS9 and RGS11. They share a common domain architecture,
                     containing, beside the RGS domain; cd04450"
                     /db_xref="CDD:239897"
     Region          116..217
                     /region_name="RGS_DHEX"
                     /note="Regulator of G-protein signalling DHEX domain;
                     pfam18148"
                     /db_xref="CDD:375589"
     Region          258..319
                     /region_name="GGL"
                     /note="G protein gamma subunit-like motifs; smart00224"
                     /db_xref="CDD:128520"
     Site            order(258,261,265,268,272,277,279,282..283,286..287,290,
                     299..300,309)
                     /site_type="other"
                     /note="beta subunit binding site [polypeptide binding]"
                     /db_xref="CDD:238024"
     Region          328..452
                     /region_name="RGS_RGS6"
                     /note="Regulator of G protein signaling (RGS) domain found
                     in the RGS6 protein; cd08737"
                     /db_xref="CDD:188691"
     Site            order(342,373..377,418..420,423,430,434)
                     /site_type="other"
                     /note="G-beta-5 interaction site"
                     /db_xref="CDD:188691"
     Site            order(357..359,361..362,395..397,399..401,403..405,428,
                     431..432,434..436,440)
                     /site_type="other"
                     /note="G-alpha interaction site"
                     /db_xref="CDD:188691"
     CDS             1..460
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /coded_by="XM_017021832.3:534..1916"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
ORIGIN      
        1 maqgsgdqra vgvadpeess pnmivyckie diitkmqddk tggvpirtvk sflskipsvv
       61 tgtdivqwlm knlsiedpve aihlgsliaa qgyifpisdh vltmkddgtf yrfqapyfwp
      121 sncwepentd yaiylckrtm qnkarlelad yeaenlarlq rafarkwefi fmqaeaqvki
      181 drkkdkterk ildsqerafw dvhrpvpgcv nttemdirkc rrlknpqkvk ksvygvtees
      241 qaqspvhvls qpirkttked irkqitflna qidrhclkms kvaesliayt eqyveydpli
      301 tpaepsnpwi sddvalwdie mskepsqqrv krwgfsfdei lkdqvgrdqf lrflesefss
      361 enlrfwlavq dlkkqplqdv akrveeiwqe flapgapsai nldshsyeit sqnvkdggry
      421 tfedaqehiy klmksdsyar flrsnayqdl llakkkvwll
//
LOCUS       XP_024305544             453 aa            linear   PRI 05-AUG-2025
DEFINITION  regulator of G-protein signaling 6 isoform X16 [Homo sapiens].
ACCESSION   XP_024305544
VERSION     XP_024305544.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449776.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..453
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..453
                     /product="regulator of G-protein signaling 6 isoform X16"
                     /calculated_mol_wt=52114
     Region          31..119
                     /region_name="DEP_RGS7-like"
                     /note="DEP (Dishevelled, Egl-10, and Pleckstrin) domain
                     found in RGS (regulator of G-protein signaling) proteins
                     of the subfamily R7. This subgroup contains RGS7, RGS6,
                     RGS9 and RGS11. They share a common domain architecture,
                     containing, beside the RGS domain; cd04450"
                     /db_xref="CDD:239897"
     Region          116..217
                     /region_name="RGS_DHEX"
                     /note="Regulator of G-protein signalling DHEX domain;
                     pfam18148"
                     /db_xref="CDD:375589"
     Region          258..>285
                     /region_name="GGL"
                     /note="G protein gamma subunit-like motifs, the
                     alpha-helical G-gamma chain dimerizes with the G-beta
                     propeller subunit as part of the heterotrimeric G-protein
                     complex; involved in signal transduction via
                     G-protein-coupled receptors; cl00069"
                     /db_xref="CDD:469600"
     Region          291..415
                     /region_name="RGS_RGS6"
                     /note="Regulator of G protein signaling (RGS) domain found
                     in the RGS6 protein; cd08737"
                     /db_xref="CDD:188691"
     Site            order(305,336..340,381..383,386,393,397)
                     /site_type="other"
                     /note="G-beta-5 interaction site"
                     /db_xref="CDD:188691"
     Site            order(320..322,324..325,358..360,362..364,366..368,391,
                     394..395,397..399,403)
                     /site_type="other"
                     /note="G-alpha interaction site"
                     /db_xref="CDD:188691"
     CDS             1..453
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /coded_by="XM_024449776.2:534..1895"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
ORIGIN      
        1 maqgsgdqra vgvadpeess pnmivyckie diitkmqddk tggvpirtvk sflskipsvv
       61 tgtdivqwlm knlsiedpve aihlgsliaa qgyifpisdh vltmkddgtf yrfqapyfwp
      121 sncwepentd yaiylckrtm qnkarlelad yeaenlarlq rafarkwefi fmqaeaqvki
      181 drkkdkterk ildsqerafw dvhrpvpgcv nttemdirkc rrlknpqkvk ksvygvtees
      241 qaqspvhvls qpirkttked irkqitflna qidrhclkms kvaeskepsq qrvkrwgfsf
      301 deilkdqvgr dqflrflese fssenlrfwl avqdlkkqpl qdvakrveei wqeflapgap
      361 sainldshsy eitsqnvkdg grytfedaqe hiyklmksds yarflrsnay qdlllakkkp
      421 eseqgrrtsl ekftrsvgks lagkrltglm qss
//
LOCUS       XP_047287946             423 aa            linear   PRI 05-AUG-2025
DEFINITION  regulator of G-protein signaling 6 isoform X17 [Homo sapiens].
ACCESSION   XP_047287946
VERSION     XP_047287946.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047431990.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..423
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..423
                     /product="regulator of G-protein signaling 6 isoform X17"
                     /calculated_mol_wt=48920
     Region          31..119
                     /region_name="DEP_RGS7-like"
                     /note="DEP (Dishevelled, Egl-10, and Pleckstrin) domain
                     found in RGS (regulator of G-protein signaling) proteins
                     of the subfamily R7. This subgroup contains RGS7, RGS6,
                     RGS9 and RGS11. They share a common domain architecture,
                     containing, beside the RGS domain; cd04450"
                     /db_xref="CDD:239897"
     Region          116..217
                     /region_name="RGS_DHEX"
                     /note="Regulator of G-protein signalling DHEX domain;
                     pfam18148"
                     /db_xref="CDD:375589"
     Region          258..>285
                     /region_name="GGL"
                     /note="G protein gamma subunit-like motifs, the
                     alpha-helical G-gamma chain dimerizes with the G-beta
                     propeller subunit as part of the heterotrimeric G-protein
                     complex; involved in signal transduction via
                     G-protein-coupled receptors; cl00069"
                     /db_xref="CDD:469600"
     Region          291..415
                     /region_name="RGS_RGS6"
                     /note="Regulator of G protein signaling (RGS) domain found
                     in the RGS6 protein; cd08737"
                     /db_xref="CDD:188691"
     Site            order(305,336..340,381..383,386,393,397)
                     /site_type="other"
                     /note="G-beta-5 interaction site"
                     /db_xref="CDD:188691"
     Site            order(320..322,324..325,358..360,362..364,366..368,391,
                     394..395,397..399,403)
                     /site_type="other"
                     /note="G-alpha interaction site"
                     /db_xref="CDD:188691"
     CDS             1..423
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /coded_by="XM_047431990.1:534..1805"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
ORIGIN      
        1 maqgsgdqra vgvadpeess pnmivyckie diitkmqddk tggvpirtvk sflskipsvv
       61 tgtdivqwlm knlsiedpve aihlgsliaa qgyifpisdh vltmkddgtf yrfqapyfwp
      121 sncwepentd yaiylckrtm qnkarlelad yeaenlarlq rafarkwefi fmqaeaqvki
      181 drkkdkterk ildsqerafw dvhrpvpgcv nttemdirkc rrlknpqkvk ksvygvtees
      241 qaqspvhvls qpirkttked irkqitflna qidrhclkms kvaeskepsq qrvkrwgfsf
      301 deilkdqvgr dqflrflese fssenlrfwl avqdlkkqpl qdvakrveei wqeflapgap
      361 sainldshsy eitsqnvkdg grytfedaqe hiyklmksds yarflrsnay qdlllakkkv
      421 wll
//
LOCUS       XP_016877322             376 aa            linear   PRI 05-AUG-2025
DEFINITION  regulator of G-protein signaling 6 isoform X18 [Homo sapiens].
ACCESSION   XP_016877322
VERSION     XP_016877322.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021833.3
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 1% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..376
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..376
                     /product="regulator of G-protein signaling 6 isoform X18"
                     /calculated_mol_wt=43098
     Region          31..119
                     /region_name="DEP_RGS7-like"
                     /note="DEP (Dishevelled, Egl-10, and Pleckstrin) domain
                     found in RGS (regulator of G-protein signaling) proteins
                     of the subfamily R7. This subgroup contains RGS7, RGS6,
                     RGS9 and RGS11. They share a common domain architecture,
                     containing, beside the RGS domain; cd04450"
                     /db_xref="CDD:239897"
     Region          116..217
                     /region_name="RGS_DHEX"
                     /note="Regulator of G-protein signalling DHEX domain;
                     pfam18148"
                     /db_xref="CDD:375589"
     Region          258..319
                     /region_name="GGL"
                     /note="G protein gamma subunit-like motifs; smart00224"
                     /db_xref="CDD:128520"
     Site            order(258,261,265,268,272,277,279,282..283,286..287,290,
                     299..300,309)
                     /site_type="other"
                     /note="beta subunit binding site [polypeptide binding]"
                     /db_xref="CDD:238024"
     Region          328..>375
                     /region_name="RGS"
                     /note="Regulator of G protein signaling (RGS) domain
                     superfamily; cl02565"
                     /db_xref="CDD:470619"
     CDS             1..376
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /coded_by="XM_017021833.3:534..1664"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
ORIGIN      
        1 maqgsgdqra vgvadpeess pnmivyckie diitkmqddk tggvpirtvk sflskipsvv
       61 tgtdivqwlm knlsiedpve aihlgsliaa qgyifpisdh vltmkddgtf yrfqapyfwp
      121 sncwepentd yaiylckrtm qnkarlelad yeaenlarlq rafarkwefi fmqaeaqvki
      181 drkkdkterk ildsqerafw dvhrpvpgcv nttemdirkc rrlknpqkvk ksvygvtees
      241 qaqspvhvls qpirkttked irkqitflna qidrhclkms kvaesliayt eqyveydpli
      301 tpaepsnpwi sddvalwdie mskepsqqrv krwgfsfdei lkdqvgrdqf lrflesefss
      361 enlracaagk glplqs
//
LOCUS       XP_024305547            1632 aa            linear   PRI 05-AUG-2025
DEFINITION  protein TALPID3 isoform X1 [Homo sapiens].
ACCESSION   XP_024305547
VERSION     XP_024305547.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449779.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1632
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1632
                     /product="protein TALPID3 isoform X1"
                     /calculated_mol_wt=180467
     Region          116..1398
                     /region_name="TALPID3"
                     /note="Hedgehog signalling target; pfam15324"
                     /db_xref="CDD:434634"
     CDS             1..1632
                     /gene="KIAA0586"
                     /gene_synonym="JBTS23; SRTD14; Talpid3"
                     /coded_by="XM_024449779.2:547..5445"
                     /db_xref="GeneID:9786"
                     /db_xref="HGNC:HGNC:19960"
                     /db_xref="MIM:610178"
ORIGIN      
        1 mkgsevslek kkkikmpvkr lrevvsqnhg dhlvllkdel pcvppalsan krlpvgtgts
       61 lngtsrgssd ltsarncyqp llenpmvses dfskdvavqv lpldkieenn kqkandifis
      121 qytmgqkdal rtvlkqnvsl cltgwsdhsg vitthcslyl lrlmrsshls lpsswdyraq
      181 smpvfkevkv hlledagiek davtqetris psgidsattv aaataaaiat aaplikvqsd
      241 leakvnsvte llsklqetdk hlqrvteqqt siqrkqeklh chdhekqmnv fmeqhirhle
      301 klqqqqidiq thfisaalkt ssfqpvsmps sravekysvk pehpnlgscn pslyntfask
      361 qaplkevedt sfdkqksple tpaprrfapv pvsrddelsk renlleeken mevschrgnv
      421 rlleqilnnn dsltrksess nttsltrski gwtpektnrf psceelettk vtmqksddvl
      481 hdlgqkeket nsmvqpkesl smlklpdlpq nsvklqttnt trsvlkdaek ilrgvqnnkk
      541 vleenleaii rakdgaamys linalstnre msekirirkt vdewiktisa eiqdelsrtd
      601 yeqkrfdqkn qrtkkgqnmt kdirtntqdk tvnksviprk hsqkqieehf rnlpmrgmpa
      661 sslqkerkeg llkattviqd edymlqvygk pvyqghrstl kkgpylrfns pspksrpqrp
      721 kviervkgtk vksirtqtdf yatkpkkmds kmkhsvpvlp hgdqqylfsp sremptfsgt
      781 leghlipmai llgqtqsnsd tmppagvivs kphpvtvtts ippssrkvet gvkkpniaiv
      841 emksekkdpp qltvqvlpsv didsisnssa dvlsplsspk easlppvqtw iktpeimkvd
      901 eeevkfpgtn fdeiidviqe eekcdeipds epilefnrsv kadstkyngp pfppvastfq
      961 ptadildkvi erketlensl iqwveqeims riisglfpvq qqiapsisvs vsetseplts
     1021 divegtssga lqlfvdagvp vnsnvikhfv nealaetiav mlgdreakkq gpvatgvsgd
     1081 astnetylpa rvctplptpq ptppcspssp akecvlvktp dsspcdsdhd mafpvkeica
     1141 ekgddmpaim lvntptvtpt ttpppaaavf tptlsdisid klkvsspelp kpwgdgdlpl
     1201 eeenpnspqe elhpraivms vakdeepesm dfpaqppppe pvpfmpfpag tkapspsqmp
     1261 gsdsstlest lsvtvtetet ldkpisegei lfscgqklap kilediglyl tnlndslsst
     1321 lhdavemedd ppsegqvirm shkkfhadai lsfakqnqes avsqqavyhs edlensvgel
     1381 segqrpqlta aaenilmghs lymqppvtnt qsldqqcdpk plsrqfdtvs gsiyedscas
     1441 hgpmslgele lepnsklvlp ttlltaqend vnlpvaaedf sqyqlkqnqd vkqvehkpsq
     1501 sylrvrnksd iapsqqqvsp gdmdrtqiel npyltcvfsg lgvhvkkvsc igklglwrfv
     1561 iqiissprwe ssatlrftda pcqdvsdaav seprgllsvs esqhnagghg vfggryllng
     1621 krqpaqclch wf
//
LOCUS       XP_024305548            1599 aa            linear   PRI 05-AUG-2025
DEFINITION  protein TALPID3 isoform X2 [Homo sapiens].
ACCESSION   XP_024305548
VERSION     XP_024305548.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449780.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1599
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1599
                     /product="protein TALPID3 isoform X2"
                     /calculated_mol_wt=176662
     Region          116..1365
                     /region_name="TALPID3"
                     /note="Hedgehog signalling target; pfam15324"
                     /db_xref="CDD:434634"
     CDS             1..1599
                     /gene="KIAA0586"
                     /gene_synonym="JBTS23; SRTD14; Talpid3"
                     /coded_by="XM_024449780.2:547..5346"
                     /db_xref="GeneID:9786"
                     /db_xref="HGNC:HGNC:19960"
                     /db_xref="MIM:610178"
ORIGIN      
        1 mkgsevslek kkkikmpvkr lrevvsqnhg dhlvllkdel pcvppalsan krlpvgtgts
       61 lngtsrgssd ltsarncyqp llenpmvses dfskdvavqv lpldkieenn kqkandifis
      121 qytmgqkdal rtvlkqkaqs mpvfkevkvh lledagiekd avtqetrisp sgidsattva
      181 aataaaiata aplikvqsdl eakvnsvtel lsklqetdkh lqrvteqqts iqrkqeklhc
      241 hdhekqmnvf meqhirhlek lqqqqidiqt hfisaalkts sfqpvsmpss ravekysvkp
      301 ehpnlgscnp slyntfaskq aplkevedts fdkqksplet paprrfapvp vsrddelskr
      361 enlleekenm evschrgnvr lleqilnnnd sltrksessn ttsltrskig wtpektnsve
      421 tlpsqrfpsc eelettkvtm qksddvlhdl gqkeketnsm vqpkeslsml klpdlpqnsv
      481 klqttnttrs vlkdaekilr gvqnnkkvle enleaiirak dgaamyslin alstnremse
      541 kirirktvde wiktisaeiq delsrtdyeq krfdqknqrt kkgqnmtkdi rtntqdktvn
      601 ksviprkhsq kqieehfrnl pmrgmpassl qkerkegllk attviqdedy mlqvygkpvy
      661 qghrstlkkg pylrfnspsp ksrpqrpkvi ervkgtkvks irtqtdfyat kpkkmdskmk
      721 hsvpvlphgd qqylfspsre mptfsgtleg hlipmaillg qtqsnsdtmp pagvivskph
      781 pvtvttsipp ssrkvetgvk kpniaivemk sekkdppqlt vqvlpsvdid sisnssadvl
      841 splsspkeas lppvqtwikt peimkvdeee vkfpgtnfde iidviqeeek cdeipdsepi
      901 lefnrsvkad stkyngppfp pvastfqpta dildkvierk etlensliqw veqeimsrii
      961 sglfpvqqqi apsisvsvse tsepltsdiv egtssgalql fvdagvpvns nvikhfvnea
     1021 laetiavmlg dreakkqgpv atgvsgdast netylparvc tplptpqptp pcspsspake
     1081 cvlvktpdss pcdsdhdmaf pvkeicaekg ddmpaimlvn tptvtptttp ppaaavftpt
     1141 lsdisidklk vsspelpkpw gdgdlpleee npnspqeelh praivmsvak deepesmdfp
     1201 aqppppepvp fmpfpagtka pspsqmpgsd sstlestlsv tvtetetldk pisegeilfs
     1261 cgqklapkil ediglyltnl ndslsstlhd avemeddpps egqvirmshk kfhadailsf
     1321 akqnqesavs qqavyhsedl ensvgelseg qrpqltaaae nilmghslym qppvtntqsl
     1381 dqqcdpkpls rqfdtvsgsi yedscashgp mslgelelep nsklvlpttl ltaqendvnl
     1441 pvaaedfsqy qlkqnqdvkq vehkpsqsyl rvrnksdiap sqqqvspgdm drtqielnpy
     1501 ltcvfsglgv hvkkvscigk lglwrfviqi issprwessa tlrftdapcq dvsdaavsep
     1561 rgllsvsesq hnagghgvfg gryllngkrq paqclchwf
//
LOCUS       XP_047287957            1547 aa            linear   PRI 05-AUG-2025
DEFINITION  protein TALPID3 isoform X5 [Homo sapiens].
ACCESSION   XP_047287957
VERSION     XP_047287957.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432001.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1547
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1547
                     /product="protein TALPID3 isoform X5"
                     /calculated_mol_wt=170897
     Region          116..1313
                     /region_name="TALPID3"
                     /note="Hedgehog signalling target; pfam15324"
                     /db_xref="CDD:434634"
     CDS             1..1547
                     /gene="KIAA0586"
                     /gene_synonym="JBTS23; SRTD14; Talpid3"
                     /coded_by="XM_047432001.1:547..5190"
                     /db_xref="GeneID:9786"
                     /db_xref="HGNC:HGNC:19960"
                     /db_xref="MIM:610178"
ORIGIN      
        1 mkgsevslek kkkikmpvkr lrevvsqnhg dhlvllkdel pcvppalsan krlpvgtgts
       61 lngtsrgssd ltsarncyqp llenpmvses dfskdvavqv lpldkieenn kqkandifis
      121 qytmgqkdal rtvlkqkaqs mpvfkevkvh lledagiekd avtqetrisp sgidsattva
      181 aataaaiata aplikvqsdl eakvnsvtel lsklqetdkh lqrvteqqts iqrkqeklhc
      241 hdhekqmnvf meqhirhlek lqqqqidiqt hfisaalkts sfqpvsmpss ravekysvkp
      301 ehpnlgscnp slyntfaskq aplkevedts fdkqksplet paprrfapvp vsrddelskr
      361 enlleekenm evschrgnvr lleqilnnnd sltrksessn ttsltrskig wtpektnrfp
      421 sceelettkv tmqksddvlh dlgqkeketn smvqpkesls mlklpdlpqn svklqttntt
      481 rsvlkdaeki lrgvqnnkkv leenleaiir akdgaamysl inalstnrem sekirirktv
      541 dewiktisae iqdelsrtdy eqkrfdqknq rtkkgqnmtk dirtntqdkt vnksviprkh
      601 sqkqieehfr nlpmrgmpas slqkerkegl lkattviqde dymlqvygkp vyqghrstlk
      661 kgpylrfnsp spksrpqrpk viervkgtkv ksirtqtdfy atkpkkmdsk mkhsvpvlph
      721 gdqqylfsps remptfsgtl eghlipmail lgqtqsnsdt mppagvivsk phpvtvttsi
      781 ppssrkvetg vkkpniaive mksekkdppq ltvqvlpsvd idsisnssad vlsplsspke
      841 aslppvqtwi ktpeimkvde eevkfpgtnf deiidviqee ekcdeipdse pilefnrsvk
      901 adstkyngpp fppvastfqp tadildkvie rketlensli qwveqeimsr iisglfpvqq
      961 qiapsisvsv setsepltsd ivegtssgal qlfvdagvpv nsnvikhfvn ealaetiavm
     1021 lgdreakkqg pvatgvsgda stnetylpar vctplptpqp tppcspsspa kecvlvktpd
     1081 sspcdsdhdm afpvkeicae kgddmpaiml vntptvtptt tpppaaavft ptlsdisidk
     1141 lkvsspelpk pwgdgdlple eenpnspqee lhpraivmsv akdeepesmd fpaqppppep
     1201 vpfmpfpagt kapspsqmpg sdsstlestl svtvtetetl dkpisegeil fscgqklapk
     1261 ilediglylt nlndslsstl hdavemdlen svgelsegqr pqltaaaeni lmghslymqp
     1321 pvtntqsldq qcdpkplsrq fdtvsgsiye dscashgpms lgelelepns klvlpttllt
     1381 aqendvnlpv aaedfsqyql kqnqdvkqve hkpsqsylrv rnksdiapsq qqvspgdmdr
     1441 tqielnpylt cvfsglgvhv kkvscigklg lwrfviqiis sprwessatl rftdapcqdv
     1501 sdaavseprg llsvsesqhn agghgvfggr yllngkrqpa qclchwf
//
LOCUS       XP_047287958            1547 aa            linear   PRI 05-AUG-2025
DEFINITION  protein TALPID3 isoform X6 [Homo sapiens].
ACCESSION   XP_047287958
VERSION     XP_047287958.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432002.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1547
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1547
                     /product="protein TALPID3 isoform X6"
                     /calculated_mol_wt=171221
     Region          31..1313
                     /region_name="TALPID3"
                     /note="Hedgehog signalling target; pfam15324"
                     /db_xref="CDD:434634"
     CDS             1..1547
                     /gene="KIAA0586"
                     /gene_synonym="JBTS23; SRTD14; Talpid3"
                     /coded_by="XM_047432002.1:196..4839"
                     /db_xref="GeneID:9786"
                     /db_xref="HGNC:HGNC:19960"
                     /db_xref="MIM:610178"
ORIGIN      
        1 mvsesdfskd vavqvlpldk ieennkqkan difisqytmg qkdalrtvlk qnvslcltgw
       61 sdhsgvitth cslyllrlmr sshlslpssw dyraqsmpvf kevkvhlled agiekdavtq
      121 etrispsgid sattvaaata aaiataapli kvqsdleakv nsvtellskl qetdkhlqrv
      181 teqqtsiqrk qeklhchdhe kqmnvfmeqh irhleklqqq qidiqthfis aalktssfqp
      241 vsmpssrave kysvkpehpn lgscnpslyn tfaskqaplk evedtsfdkq kspletpapr
      301 rfapvpvsrd delskrenll eekenmevsc hrgnvrlleq ilnnndsltr ksessnttsl
      361 trskigwtpe ktnrfpscee lettkvtmqk sddvlhdlgq keketnsmvq pkeslsmlkl
      421 pdlpqnsvkl qttnttrsvl kdaekilrgv qnnkkvleen leaiirakdg aamyslinal
      481 stnremseki rirktvdewi ktisaeiqde lsrtdyeqkr fdqknqrtkk gqnmtkdirt
      541 ntqdktvnks viprkhsqkq ieehfrnlpm rgmpasslqk erkegllkat tviqdedyml
      601 qvygkpvyqg hrstlkkgpy lrfnspspks rpqrpkvier vkgtkvksir tqtdfyatkp
      661 kkmdskmkhs vpvlphgdqq ylfspsremp tfsgtleghl ipmaillgqt qsnsdtmppa
      721 gvivskphpv tvttsippss rkvetgvkkp niaivemkse kkdppqltvq vlpsvdidsi
      781 snssadvlsp lsspkeaslp pvqtwiktpe imkvdeeevk fpgtnfdeii dviqeeekcd
      841 eipdsepile fnrsvkadst kyngppfppv astfqptadi ldkvierket lensliqwve
      901 qeimsriisg lfpvqqqiap sisvsvsets epltsdiveg tssgalqlfv dagvpvnsnv
      961 ikhfvneala etiavmlgdr eakkqgpvat gvsgdastne tylparvctp lptpqptppc
     1021 spsspakecv lvktpdsspc dsdhdmafpv keicaekgdd mpaimlvntp tvtptttppp
     1081 aaavftptls disidklkvs spelpkpwgd gdlpleeenp nspqeelhpr aivmsvakde
     1141 epesmdfpaq ppppepvpfm pfpagtkaps psqmpgsdss tlestlsvtv tetetldkpi
     1201 segeilfscg qklapkiled iglyltnlnd slsstlhdav emeddppseg qvirmshkkf
     1261 hadailsfak qnqesavsqq avyhsedlen svgelsegqr pqltaaaeni lmghslymqp
     1321 pvtntqsldq qcdpkplsrq fdtvsgsiye dscashgpms lgelelepns klvlpttllt
     1381 aqendvnlpv aaedfsqyql kqnqdvkqve hkpsqsylrv rnksdiapsq qqvspgdmdr
     1441 tqielnpylt cvfsglgvhv kkvscigklg lwrfviqiis sprwessatl rftdapcqdv
     1501 sdaavseprg llsvsesqhn agghgvfggr yllngkrqpa qclchwf
//
LOCUS       XP_047287959            1545 aa            linear   PRI 05-AUG-2025
DEFINITION  protein TALPID3 isoform X7 [Homo sapiens].
ACCESSION   XP_047287959
VERSION     XP_047287959.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432003.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1545
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1545
                     /product="protein TALPID3 isoform X7"
                     /calculated_mol_wt=170615
     Region          116..1354
                     /region_name="TALPID3"
                     /note="Hedgehog signalling target; pfam15324"
                     /db_xref="CDD:434634"
     CDS             1..1545
                     /gene="KIAA0586"
                     /gene_synonym="JBTS23; SRTD14; Talpid3"
                     /coded_by="XM_047432003.1:547..5184"
                     /db_xref="GeneID:9786"
                     /db_xref="HGNC:HGNC:19960"
                     /db_xref="MIM:610178"
ORIGIN      
        1 mkgsevslek kkkikmpvkr lrevvsqnhg dhlvllkdel pcvppalsan krlpvgtgts
       61 lngtsrgssd ltsarncyqp llenpmvses dfskdvavqv lpldkieenn kqkandifis
      121 qytmgqkdal rtvlkqnvsl cltgwsdhsg vitthcslyl lrlmrsshls lpsswdyraq
      181 smpvfkevkv hlledagiek davtqetris psgidsattv aaataaaiat aaplikvqsd
      241 leakvnsvte llsklqetdk hlqrvteqqt siqrkqeklh chdhekqmnv fmeqhirhle
      301 klqqqqidiq thfisaalkt ssfqpvsmps sravekysvk pehpnlgscn pslyntfask
      361 qaplkevedt sfdkqksple tpaprrfapv pvsrddelsk renlleeken mevschrgnv
      421 rlleqilnnn dsltrksess nttsltrski gwtpektnrf psceelettk vtmqksddvl
      481 hdlgqkeket nsmvqpkesl smlklpdlpq nsvklqttnt trsvlkdaek ilrgvqnnkk
      541 vleenleaii rakdgaamys linalstnre msekirirkt vdewiktisa eiqdelsrtd
      601 yeqkrfdqkn qrtkkgqnmt kdirtntqdk tvnksviprk hsqkqieehf rnlpmrgmpa
      661 sslqkerkeg llkattviqd edymlqvygk pvyqghrstl kkgpylrfns pspksrpqrp
      721 kviervkgtk vksirtqtdf yatkpkkmds kmkhsvpvlp hgdqqylfsp sremptfsgt
      781 leghlipmai llgqtqsnsd tmppagvivs kphpvtvtts ippssrkvet gvkkpniaiv
      841 emksekkdpp qltvqvlpsv didsisnssa dvlsplsspk easlppvqtw iktpeimkvd
      901 eeevkfpgtn fdeiidviqe eekcdeipds epilefnrsv kadstkyngp pfppvastfq
      961 ptadildkvi erketlensl iqwveqeims riisglfpvq qqiapsisvs vsetseplts
     1021 divegtssga lqlfvdagvp vnsnvikhfv nealaetiav mlgdreakkq gpvatgvsgd
     1081 astnetylpa rvctplptpq ptppcspssp akecvlvktp dsspcdsdhd mafpvkeica
     1141 ekgddmpaim lvntptvtpt ttpppaaavf tptlsdisid klkvsspelp kpwgdgdlpl
     1201 eeenpnspqe elhpraivms vakdeepesm dfpaqppppe pvpfmpfpag tkapspsqmp
     1261 gsdsstlest lsvtvtetet ldkpisegei lfscgqklap kilediglyl tnlndslsst
     1321 lhdavemdle nsvgelsegq rpqltaaaen ilmghslymq ppvtntqsld qqcdpkplsr
     1381 qfdtvsgsiy edscashgpm slgelelepn sklvlpttll taqendvnlp vaaedfsqyq
     1441 lkqnqdvkqv ehkpsqsylr vrnksdiaps qqqvspgdmd rtqielnpyl tcvfsggkav
     1501 plsasqmppa kmsvmlpsvn ledcsqslsl stmqedmess gadtf
//
LOCUS       XP_047287962            1523 aa            linear   PRI 05-AUG-2025
DEFINITION  protein TALPID3 isoform X10 [Homo sapiens].
ACCESSION   XP_047287962
VERSION     XP_047287962.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432006.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1523
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1523
                     /product="protein TALPID3 isoform X10"
                     /calculated_mol_wt=168147
     Region          116..1354
                     /region_name="TALPID3"
                     /note="Hedgehog signalling target; pfam15324"
                     /db_xref="CDD:434634"
     CDS             1..1523
                     /gene="KIAA0586"
                     /gene_synonym="JBTS23; SRTD14; Talpid3"
                     /coded_by="XM_047432006.1:547..5118"
                     /db_xref="GeneID:9786"
                     /db_xref="HGNC:HGNC:19960"
                     /db_xref="MIM:610178"
ORIGIN      
        1 mkgsevslek kkkikmpvkr lrevvsqnhg dhlvllkdel pcvppalsan krlpvgtgts
       61 lngtsrgssd ltsarncyqp llenpmvses dfskdvavqv lpldkieenn kqkandifis
      121 qytmgqkdal rtvlkqnvsl cltgwsdhsg vitthcslyl lrlmrsshls lpsswdyraq
      181 smpvfkevkv hlledagiek davtqetris psgidsattv aaataaaiat aaplikvqsd
      241 leakvnsvte llsklqetdk hlqrvteqqt siqrkqeklh chdhekqmnv fmeqhirhle
      301 klqqqqidiq thfisaalkt ssfqpvsmps sravekysvk pehpnlgscn pslyntfask
      361 qaplkevedt sfdkqksple tpaprrfapv pvsrddelsk renlleeken mevschrgnv
      421 rlleqilnnn dsltrksess nttsltrski gwtpektnrf psceelettk vtmqksddvl
      481 hdlgqkeket nsmvqpkesl smlklpdlpq nsvklqttnt trsvlkdaek ilrgvqnnkk
      541 vleenleaii rakdgaamys linalstnre msekirirkt vdewiktisa eiqdelsrtd
      601 yeqkrfdqkn qrtkkgqnmt kdirtntqdk tvnksviprk hsqkqieehf rnlpmrgmpa
      661 sslqkerkeg llkattviqd edymlqvygk pvyqghrstl kkgpylrfns pspksrpqrp
      721 kviervkgtk vksirtqtdf yatkpkkmds kmkhsvpvlp hgdqqylfsp sremptfsgt
      781 leghlipmai llgqtqsnsd tmppagvivs kphpvtvtts ippssrkvet gvkkpniaiv
      841 emksekkdpp qltvqvlpsv didsisnssa dvlsplsspk easlppvqtw iktpeimkvd
      901 eeevkfpgtn fdeiidviqe eekcdeipds epilefnrsv kadstkyngp pfppvastfq
      961 ptadildkvi erketlensl iqwveqeims riisglfpvq qqiapsisvs vsetseplts
     1021 divegtssga lqlfvdagvp vnsnvikhfv nealaetiav mlgdreakkq gpvatgvsgd
     1081 astnetylpa rvctplptpq ptppcspssp akecvlvktp dsspcdsdhd mafpvkeica
     1141 ekgddmpaim lvntptvtpt ttpppaaavf tptlsdisid klkvsspelp kpwgdgdlpl
     1201 eeenpnspqe elhpraivms vakdeepesm dfpaqppppe pvpfmpfpag tkapspsqmp
     1261 gsdsstlest lsvtvtetet ldkpisegei lfscgqklap kilediglyl tnlndslsst
     1321 lhdavemdle nsvgelsegq rpqltaaaen ilmghslymq ppvtntqsld qqcdpkplsr
     1381 qfdtvsgsiy edscashgpm slgelelepn sklvlpttll taqendvnlp vaaedfsqyq
     1441 lkqnqdvkqv ehkpsqsylr vrnksdiaps qqqggkavpl sasqmppakm svmlpsvnle
     1501 dcsqslslst mqedmessga dtf
//
LOCUS       XP_047287963            1518 aa            linear   PRI 05-AUG-2025
DEFINITION  protein TALPID3 isoform X11 [Homo sapiens].
ACCESSION   XP_047287963
VERSION     XP_047287963.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432007.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1518
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1518
                     /product="protein TALPID3 isoform X11"
                     /calculated_mol_wt=167954
     Region          116..1398
                     /region_name="TALPID3"
                     /note="Hedgehog signalling target; pfam15324"
                     /db_xref="CDD:434634"
     CDS             1..1518
                     /gene="KIAA0586"
                     /gene_synonym="JBTS23; SRTD14; Talpid3"
                     /coded_by="XM_047432007.1:547..5103"
                     /db_xref="GeneID:9786"
                     /db_xref="HGNC:HGNC:19960"
                     /db_xref="MIM:610178"
ORIGIN      
        1 mkgsevslek kkkikmpvkr lrevvsqnhg dhlvllkdel pcvppalsan krlpvgtgts
       61 lngtsrgssd ltsarncyqp llenpmvses dfskdvavqv lpldkieenn kqkandifis
      121 qytmgqkdal rtvlkqnvsl cltgwsdhsg vitthcslyl lrlmrsshls lpsswdyraq
      181 smpvfkevkv hlledagiek davtqetris psgidsattv aaataaaiat aaplikvqsd
      241 leakvnsvte llsklqetdk hlqrvteqqt siqrkqeklh chdhekqmnv fmeqhirhle
      301 klqqqqidiq thfisaalkt ssfqpvsmps sravekysvk pehpnlgscn pslyntfask
      361 qaplkevedt sfdkqksple tpaprrfapv pvsrddelsk renlleeken mevschrgnv
      421 rlleqilnnn dsltrksess nttsltrski gwtpektnrf psceelettk vtmqksddvl
      481 hdlgqkeket nsmvqpkesl smlklpdlpq nsvklqttnt trsvlkdaek ilrgvqnnkk
      541 vleenleaii rakdgaamys linalstnre msekirirkt vdewiktisa eiqdelsrtd
      601 yeqkrfdqkn qrtkkgqnmt kdirtntqdk tvnksviprk hsqkqieehf rnlpmrgmpa
      661 sslqkerkeg llkattviqd edymlqvygk pvyqghrstl kkgpylrfns pspksrpqrp
      721 kviervkgtk vksirtqtdf yatkpkkmds kmkhsvpvlp hgdqqylfsp sremptfsgt
      781 leghlipmai llgqtqsnsd tmppagvivs kphpvtvtts ippssrkvet gvkkpniaiv
      841 emksekkdpp qltvqvlpsv didsisnssa dvlsplsspk easlppvqtw iktpeimkvd
      901 eeevkfpgtn fdeiidviqe eekcdeipds epilefnrsv kadstkyngp pfppvastfq
      961 ptadildkvi erketlensl iqwveqeims riisglfpvq qqiapsisvs vsetseplts
     1021 divegtssga lqlfvdagvp vnsnvikhfv nealaetiav mlgdreakkq gpvatgvsgd
     1081 astnetylpa rvctplptpq ptppcspssp akecvlvktp dsspcdsdhd mafpvkeica
     1141 ekgddmpaim lvntptvtpt ttpppaaavf tptlsdisid klkvsspelp kpwgdgdlpl
     1201 eeenpnspqe elhpraivms vakdeepesm dfpaqppppe pvpfmpfpag tkapspsqmp
     1261 gsdsstlest lsvtvtetet ldkpisegei lfscgqklap kilediglyl tnlndslsst
     1321 lhdavemedd ppsegqvirm shkkfhadai lsfakqnqes avsqqavyhs edlensvgel
     1381 segqrpqlta aaenilmghs lymqppvtnt qsldqqcdpk plsrqfdtvs gsiyedscas
     1441 hgpmslgele lepnsklvlp ttlltaqend vnlpvaaedf sqyqlkqnqd vkqvehkpsq
     1501 sylrvrnksd iapsqqqg
//
LOCUS       XP_047287965            1512 aa            linear   PRI 05-AUG-2025
DEFINITION  protein TALPID3 isoform X13 [Homo sapiens].
ACCESSION   XP_047287965
VERSION     XP_047287965.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432009.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1512
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1512
                     /product="protein TALPID3 isoform X13"
                     /calculated_mol_wt=166971
     Region          116..1357
                     /region_name="TALPID3"
                     /note="Hedgehog signalling target; pfam15324"
                     /db_xref="CDD:434634"
     CDS             1..1512
                     /gene="KIAA0586"
                     /gene_synonym="JBTS23; SRTD14; Talpid3"
                     /coded_by="XM_047432009.1:547..5085"
                     /db_xref="GeneID:9786"
                     /db_xref="HGNC:HGNC:19960"
                     /db_xref="MIM:610178"
ORIGIN      
        1 mkgsevslek kkkikmpvkr lrevvsqnhg dhlvllkdel pcvppalsan krlpvgtgts
       61 lngtsrgssd ltsarncyqp llenpmvses dfskdvavqv lpldkieenn kqkandifis
      121 qytmgqkdal rtvlkqkaqs mpvfkevkvh lledagiekd avtqetrisp sgidsattva
      181 aataaaiata aplikvqsdl eakvnsvtel lsklqetdkh lqrvteqqts iqrkqeklhc
      241 hdhekqmnvf meqhirhlek lqqqqidiqt hfisaalkts sfqpvsmpss ravekysvkp
      301 ehpnlgscnp slyntfaskq aplkevedts fdkqksplet paprrfapvp vsrddelskr
      361 enlleekenm evschrgnvr lleqilnnnd sltrksessn ttsltrskig wtpektnrfp
      421 sceelettkv tmqksddvlh dlgqkeketn smvqpkesls mlklpdlpqn svklqttntt
      481 rsvlkdaeki lrgvqnnkkv leenleaiir akdgaamysl inalstnrem sekirirktv
      541 dewiktisae iqdelsrtdy eqkrfdqknq rtkkgqnmtk dirtntqdkt vnksviprkh
      601 sqkqieehfr nlpmrgmpas slqkerkegl lkattviqde dymlqvygkp vyqghrstlk
      661 kgpylrfnsp spksrpqrpk viervkgtkv ksirtqtdfy atkpkkmdsk mkhsvpvlph
      721 gdqqylfsps remptfsgtl eghlipmail lgqtqsnsdt mppagvivsk phpvtvttsi
      781 ppssrkvetg vkkpniaive mksekkdppq ltvqvlpsvd idsisnssad vlsplsspke
      841 aslppvqtwi ktpeimkvde eevkfpgtnf deiidviqee ekcdeipdse pilefnrsvk
      901 adstkyngpp fppvastfqp tadildkvie rketlensli qwveqeimsr iisglfpvqq
      961 qiapsisvsv setsepltsd ivegtssgal qlfvdagvpv nsnvikhfvn ealaetiavm
     1021 lgdreakkqg pvatgvsgda stnetylpar vctplptpqp tppcspsspa kecvlvktpd
     1081 sspcdsdhdm afpvkeicae kgddmpaiml vntptvtptt tpppaaavft ptlsdisidk
     1141 lkvsspelpk pwgdgdlple eenpnspqee lhpraivmsv akdeepesmd fpaqppppep
     1201 vpfmpfpagt kapspsqmpg sdsstlestl svtvtetetl dkpisegeil fscgqklapk
     1261 ilediglylt nlndslsstl hdavemeddp psegqvirms hkkfhadail sfakqnqesa
     1321 vsqqavyhse dlensvgels egqrpqltaa aenilmghsl ymqppvtntq sldqqcdpkp
     1381 lsrqfdtvsg siyedscash gpmslgelel epnsklvlpt tlltaqendv nlpvaaedfs
     1441 qyqlkqnqdv kqvehkpsqs ylrvrnksdi apsqqqaflg aldtcsdlqa qqhchccmsv
     1501 ssmhtgngkc pg
//
LOCUS       XP_047287966            1487 aa            linear   PRI 05-AUG-2025
DEFINITION  protein TALPID3 isoform X14 [Homo sapiens].
ACCESSION   XP_047287966
VERSION     XP_047287966.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432010.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1487
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1487
                     /product="protein TALPID3 isoform X14"
                     /calculated_mol_wt=164519
     Region          116..1357
                     /region_name="TALPID3"
                     /note="Hedgehog signalling target; pfam15324"
                     /db_xref="CDD:434634"
     CDS             1..1487
                     /gene="KIAA0586"
                     /gene_synonym="JBTS23; SRTD14; Talpid3"
                     /coded_by="XM_047432010.1:547..5010"
                     /db_xref="GeneID:9786"
                     /db_xref="HGNC:HGNC:19960"
                     /db_xref="MIM:610178"
ORIGIN      
        1 mkgsevslek kkkikmpvkr lrevvsqnhg dhlvllkdel pcvppalsan krlpvgtgts
       61 lngtsrgssd ltsarncyqp llenpmvses dfskdvavqv lpldkieenn kqkandifis
      121 qytmgqkdal rtvlkqkaqs mpvfkevkvh lledagiekd avtqetrisp sgidsattva
      181 aataaaiata aplikvqsdl eakvnsvtel lsklqetdkh lqrvteqqts iqrkqeklhc
      241 hdhekqmnvf meqhirhlek lqqqqidiqt hfisaalkts sfqpvsmpss ravekysvkp
      301 ehpnlgscnp slyntfaskq aplkevedts fdkqksplet paprrfapvp vsrddelskr
      361 enlleekenm evschrgnvr lleqilnnnd sltrksessn ttsltrskig wtpektnrfp
      421 sceelettkv tmqksddvlh dlgqkeketn smvqpkesls mlklpdlpqn svklqttntt
      481 rsvlkdaeki lrgvqnnkkv leenleaiir akdgaamysl inalstnrem sekirirktv
      541 dewiktisae iqdelsrtdy eqkrfdqknq rtkkgqnmtk dirtntqdkt vnksviprkh
      601 sqkqieehfr nlpmrgmpas slqkerkegl lkattviqde dymlqvygkp vyqghrstlk
      661 kgpylrfnsp spksrpqrpk viervkgtkv ksirtqtdfy atkpkkmdsk mkhsvpvlph
      721 gdqqylfsps remptfsgtl eghlipmail lgqtqsnsdt mppagvivsk phpvtvttsi
      781 ppssrkvetg vkkpniaive mksekkdppq ltvqvlpsvd idsisnssad vlsplsspke
      841 aslppvqtwi ktpeimkvde eevkfpgtnf deiidviqee ekcdeipdse pilefnrsvk
      901 adstkyngpp fppvastfqp tadildkvie rketlensli qwveqeimsr iisglfpvqq
      961 qiapsisvsv setsepltsd ivegtssgal qlfvdagvpv nsnvikhfvn ealaetiavm
     1021 lgdreakkqg pvatgvsgda stnetylpar vctplptpqp tppcspsspa kecvlvktpd
     1081 sspcdsdhdm afpvkeicae kgddmpaiml vntptvtptt tpppaaavft ptlsdisidk
     1141 lkvsspelpk pwgdgdlple eenpnspqee lhpraivmsv akdeepesmd fpaqppppep
     1201 vpfmpfpagt kapspsqmpg sdsstlestl svtvtetetl dkpisegeil fscgqklapk
     1261 ilediglylt nlndslsstl hdavemeddp psegqvirms hkkfhadail sfakqnqesa
     1321 vsqqavyhse dlensvgels egqrpqltaa aenilmghsl ymqppvtntq sldqqcdpkp
     1381 lsrqfdtvsg siyedscash gpmslgelel epnsklvlpt tlltaqendv nlpvaaedfs
     1441 qyqlkqnqdv kqvehkpsqs ylrvrnksdi apsqqqvlis riknckn
//
LOCUS       XP_047287970            1469 aa            linear   PRI 05-AUG-2025
DEFINITION  protein TALPID3 isoform X18 [Homo sapiens].
ACCESSION   XP_047287970
VERSION     XP_047287970.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432014.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1469
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1469
                     /product="protein TALPID3 isoform X18"
                     /calculated_mol_wt=162796
     Region          116..1313
                     /region_name="TALPID3"
                     /note="Hedgehog signalling target; pfam15324"
                     /db_xref="CDD:434634"
     CDS             1..1469
                     /gene="KIAA0586"
                     /gene_synonym="JBTS23; SRTD14; Talpid3"
                     /coded_by="XM_047432014.1:547..4956"
                     /db_xref="GeneID:9786"
                     /db_xref="HGNC:HGNC:19960"
                     /db_xref="MIM:610178"
ORIGIN      
        1 mkgsevslek kkkikmpvkr lrevvsqnhg dhlvllkdel pcvppalsan krlpvgtgts
       61 lngtsrgssd ltsarncyqp llenpmvses dfskdvavqv lpldkieenn kqkandifis
      121 qytmgqkdal rtvlkqkaqs mpvfkevkvh lledagiekd avtqetrisp sgidsattva
      181 aataaaiata aplikvqsdl eakvnsvtel lsklqetdkh lqrvteqqts iqrkqeklhc
      241 hdhekqmnvf meqhirhlek lqqqqidiqt hfisaalkts sfqpvsmpss ravekysvkp
      301 ehpnlgscnp slyntfaskq aplkevedts fdkqksplet paprrfapvp vsrddelskr
      361 enlleekenm evschrgnvr lleqilnnnd sltrksessn ttsltrskig wtpektnrfp
      421 sceelettkv tmqksddvlh dlgqkeketn smvqpkesls mlklpdlpqn svklqttntt
      481 rsvlkdaeki lrgvqnnkkv leenleaiir akdgaamysl inalstnrem sekirirktv
      541 dewiktisae iqdelsrtdy eqkrfdqknq rtkkgqnmtk dirtntqdkt vnksviprkh
      601 sqkqieehfr nlpmrgmpas slqkerkegl lkattviqde dymlqvygkp vyqghrstlk
      661 kgpylrfnsp spksrpqrpk viervkgtkv ksirtqtdfy atkpkkmdsk mkhsvpvlph
      721 gdqqylfsps remptfsgtl eghlipmail lgqtqsnsdt mppagvivsk phpvtvttsi
      781 ppssrkvetg vkkpniaive mksekkdppq ltvqvlpsvd idsisnssad vlsplsspke
      841 aslppvqtwi ktpeimkvde eevkfpgtnf deiidviqee ekcdeipdse pilefnrsvk
      901 adstkyngpp fppvastfqp tadildkvie rketlensli qwveqeimsr iisglfpvqq
      961 qiapsisvsv setsepltsd ivegtssgal qlfvdagvpv nsnvikhfvn ealaetiavm
     1021 lgdreakkqg pvatgvsgda stnetylpar vctplptpqp tppcspsspa kecvlvktpd
     1081 sspcdsdhdm afpvkeicae kgddmpaiml vntptvtptt tpppaaavft ptlsdisidk
     1141 lkvsspelpk pwgdgdlple eenpnspqee lhpraivmsv akdeepesmd fpaqppppep
     1201 vpfmpfpagt kapspsqmpg sdsstlestl svtvtetetl dkpisegeil fscgqklapk
     1261 ilediglylt nlndslsstl hdavemdlen svgelsegqr pqltaaaeni lmghslymqp
     1321 pvtntqsldq qcdpkplsrq fdtvsgsiye dscashgpms lgelelepns klvlpttllt
     1381 aqendvnlpv aaedfsqyql kqnqdvkqve hkpsqsylrv rnksdiapsq qqaslyikyh
     1441 rkccgpremd ktkhllsrdk kkkghfvkr
//
LOCUS       XP_024305555            1459 aa            linear   PRI 05-AUG-2025
DEFINITION  protein TALPID3 isoform X19 [Homo sapiens].
ACCESSION   XP_024305555
VERSION     XP_024305555.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449787.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1459
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1459
                     /product="protein TALPID3 isoform X19"
                     /calculated_mol_wt=161271
     Region          5..1225
                     /region_name="TALPID3"
                     /note="Hedgehog signalling target; pfam15324"
                     /db_xref="CDD:434634"
     CDS             1..1459
                     /gene="KIAA0586"
                     /gene_synonym="JBTS23; SRTD14; Talpid3"
                     /coded_by="XM_024449787.2:511..4890"
                     /db_xref="GeneID:9786"
                     /db_xref="HGNC:HGNC:19960"
                     /db_xref="MIM:610178"
ORIGIN      
        1 mpyckaqsmp vfkevkvhll edagiekdav tqetrispsg idsattvaaa taaaiataap
       61 likvqsdlea kvnsvtells klqetdkhlq rvteqqtsiq rkqeklhchd hekqmnvfme
      121 qhirhleklq qqqidiqthf isaalktssf qpvsmpssra vekysvkpeh pnlgscnpsl
      181 yntfaskqap lkevedtsfd kqkspletpa prrfapvpvs rddelskren lleekenmev
      241 schrgnvrll eqilnnndsl trksessntt sltrskigwt pektnrfpsc eelettkvtm
      301 qksddvlhdl gqkeketnsm vqpkeslsml klpdlpqnsv klqttnttrs vlkdaekilr
      361 gvqnnkkvle enleaiirak dgaamyslin alstnremse kirirktvde wiktisaeiq
      421 delsrtdyeq krfdqknqrt kkgqnmtkdi rtntqdktvn ksviprkhsq kqieehfrnl
      481 pmrgmpassl qkerkegllk attviqdedy mlqvygkpvy qghrstlkkg pylrfnspsp
      541 ksrpqrpkvi ervkgtkvks irtqtdfyat kpkkmdskmk hsvpvlphgd qqylfspsre
      601 mptfsgtleg hlipmaillg qtqsnsdtmp pagvivskph pvtvttsipp ssrkvetgvk
      661 kpniaivemk sekkdppqlt vqvlpsvdid sisnssadvl splsspkeas lppvqtwikt
      721 peimkvdeee vkfpgtnfde iidviqeeek cdeipdsepi lefnrsvkad stkyngppfp
      781 pvastfqpta dildkvierk etlensliqw veqeimsrii sglfpvqqqi apsisvsvse
      841 tsepltsdiv egtssgalql fvdagvpvns nvikhfvnea laetiavmlg dreakkqgpv
      901 atgvsgdast netylparvc tplptpqptp pcspsspake cvlvktpdss pcdsdhdmaf
      961 pvkeicaekg ddmpaimlvn tptvtptttp ppaaavftpt lsdisidklk vsspelpkpw
     1021 gdgdlpleee npnspqeelh praivmsvak deepesmdfp aqppppepvp fmpfpagtka
     1081 pspsqmpgsd sstlestlsv tvtetetldk pisegeilfs cgqklapkil ediglyltnl
     1141 ndslsstlhd avemeddpps egqvirmshk kfhadailsf akqnqesavs qqavyhsedl
     1201 ensvgelseg qrpqltaaae nilmghslym qppvtntqsl dqqcdpkpls rqfdtvsgsi
     1261 yedscashgp mslgelelep nsklvlpttl ltaqendvnl pvaaedfsqy qlkqnqdvkq
     1321 vehkpsqsyl rvrnksdiap sqqqvspgdm drtqielnpy ltcvfsglgv hvkkvscigk
     1381 lglwrfviqi issprwessa tlrftdapcq dvsdaavsep rgllsvsesq hnagghgvfg
     1441 gryllngkrq paqclchwf
//
LOCUS       XP_024305559            1534 aa            linear   PRI 05-AUG-2025
DEFINITION  protein TALPID3 isoform X21 [Homo sapiens].
ACCESSION   XP_024305559
VERSION     XP_024305559.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449791.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1534
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..1534
                     /product="protein TALPID3 isoform X21"
                     /calculated_mol_wt=169265
     Region          116..1365
                     /region_name="TALPID3"
                     /note="Hedgehog signalling target; pfam15324"
                     /db_xref="CDD:434634"
     CDS             1..1534
                     /gene="KIAA0586"
                     /gene_synonym="JBTS23; SRTD14; Talpid3"
                     /coded_by="XM_024449791.2:547..5151"
                     /db_xref="GeneID:9786"
                     /db_xref="HGNC:HGNC:19960"
                     /db_xref="MIM:610178"
ORIGIN      
        1 mkgsevslek kkkikmpvkr lrevvsqnhg dhlvllkdel pcvppalsan krlpvgtgts
       61 lngtsrgssd ltsarncyqp llenpmvses dfskdvavqv lpldkieenn kqkandifis
      121 qytmgqkdal rtvlkqkaqs mpvfkevkvh lledagiekd avtqetrisp sgidsattva
      181 aataaaiata aplikvqsdl eakvnsvtel lsklqetdkh lqrvteqqts iqrkqeklhc
      241 hdhekqmnvf meqhirhlek lqqqqidiqt hfisaalkts sfqpvsmpss ravekysvkp
      301 ehpnlgscnp slyntfaskq aplkevedts fdkqksplet paprrfapvp vsrddelskr
      361 enlleekenm evschrgnvr lleqilnnnd sltrksessn ttsltrskig wtpektnsve
      421 tlpsqrfpsc eelettkvtm qksddvlhdl gqkeketnsm vqpkeslsml klpdlpqnsv
      481 klqttnttrs vlkdaekilr gvqnnkkvle enleaiirak dgaamyslin alstnremse
      541 kirirktvde wiktisaeiq delsrtdyeq krfdqknqrt kkgqnmtkdi rtntqdktvn
      601 ksviprkhsq kqieehfrnl pmrgmpassl qkerkegllk attviqdedy mlqvygkpvy
      661 qghrstlkkg pylrfnspsp ksrpqrpkvi ervkgtkvks irtqtdfyat kpkkmdskmk
      721 hsvpvlphgd qqylfspsre mptfsgtleg hlipmaillg qtqsnsdtmp pagvivskph
      781 pvtvttsipp ssrkvetgvk kpniaivemk sekkdppqlt vqvlpsvdid sisnssadvl
      841 splsspkeas lppvqtwikt peimkvdeee vkfpgtnfde iidviqeeek cdeipdsepi
      901 lefnrsvkad stkyngppfp pvastfqpta dildkvierk etlensliqw veqeimsrii
      961 sglfpvqqqi apsisvsvse tsepltsdiv egtssgalql fvdagvpvns nvikhfvnea
     1021 laetiavmlg dreakkqgpv atgvsgdast netylparvc tplptpqptp pcspsspake
     1081 cvlvktpdss pcdsdhdmaf pvkeicaekg ddmpaimlvn tptvtptttp ppaaavftpt
     1141 lsdisidklk vsspelpkpw gdgdlpleee npnspqeelh praivmsvak deepesmdfp
     1201 aqppppepvp fmpfpagtka pspsqmpgsd sstlestlsv tvtetetldk pisegeilfs
     1261 cgqklapkil ediglyltnl ndslsstlhd avemeddpps egqvirmshk kfhadailsf
     1321 akqnqesavs qqavyhsedl ensvgelseg qrpqltaaae nilmghslym qppvtntqsl
     1381 dqqcdpkpls rqfdtvsgsi yedscashgp mslgelelep nsklvlpttl ltaqendvnl
     1441 pvaaedfsqy qlkqnqdvkq vehkpsqsyl rvrnksdiap sqqqggkavp lsasqmppak
     1501 msvmlpsvnl edcsqslsls tmqedmessg adtf
//
LOCUS       XP_016877329             846 aa            linear   PRI 05-AUG-2025
DEFINITION  disks large-associated protein 5 isoform X1 [Homo sapiens].
ACCESSION   XP_016877329
VERSION     XP_016877329.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021840.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..846
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..846
                     /product="disks large-associated protein 5 isoform X1"
                     /calculated_mol_wt=94984
     Region          <24..>196
                     /region_name="PspC_subgroup_1"
                     /note="pneumococcal surface protein PspC, choline-binding
                     form; NF033838"
                     /db_xref="CDD:468201"
     Region          <414..601
                     /region_name="GKAP"
                     /note="Guanylate-kinase-associated protein (GKAP) protein;
                     pfam03359"
                     /db_xref="CDD:460897"
     CDS             1..846
                     /gene="DLGAP5"
                     /gene_synonym="DLG7; HURP"
                     /coded_by="XM_017021840.3:519..3059"
                     /db_xref="GeneID:9787"
                     /db_xref="HGNC:HGNC:16864"
                     /db_xref="MIM:617859"
ORIGIN      
        1 mssshfasrh rkdistemir tkiahrksls qkenrhkeye rnrhfglkdv niptlegril
       61 veldetsqgl vpektnvkpr amktilgdqr kqmlqkykee kqlqklkeqr ekakrgifkv
      121 gryrpdmpcf llsnqnavka epkkaipssv ritrskakdq meqtkidnes dvrairpgpr
      181 qtsekkvsdk ekkvvqpvmp tslrmtrsat qaakqvprtv ssttarkpvt raanenepeg
      241 kvpskgrpak nvetkpdkgi sckvdseent lnsqtnatsg mnpdgvlskm enlpeintak
      301 ikgknsfapk dfmfqpldgl ktyqvtpmtp rsanafltps ytwtplktev desqatkeil
      361 aqkcktystk tiqqdsnklp cplgpltvwh eehvlnknea ttknlnglpi kevpslerne
      421 griaqphhgv pyfrnilqse tekltshcfe wdrkleldip ddakdlirta vgqtrllmke
      481 rfkqfeglvd dceykrgike ttctdldgfw dmvsfqiedv ihkfnnlikl eesgwqvnnn
      541 mnhnmnknvf rkkvvsgias kpkqddagri aarnrlaaik namrerirqe ecaetavsvi
      601 pkevdkivfd agffrvespv klfsglsvss egpsqrlgtp ksvnkavsqs rnemgipqqt
      661 tspenagpqn tksehvkktl flsipesrss iedaqcpglp dlieenhvvn ktdlkvdcls
      721 sermslplla ggvaddintn kkegisdvve gmelnssits qdvlmsspek ntasqnsile
      781 egetkisqse lfdnksltte chlldspgln csnpftqler rhqeharhis fggnlitfsp
      841 lqpgef
//
LOCUS       XP_047287972             842 aa            linear   PRI 05-AUG-2025
DEFINITION  disks large-associated protein 5 isoform X2 [Homo sapiens].
ACCESSION   XP_047287972
VERSION     XP_047287972.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432016.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..842
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..842
                     /product="disks large-associated protein 5 isoform X2"
                     /calculated_mol_wt=94047
     Region          <24..>196
                     /region_name="PspC_subgroup_1"
                     /note="pneumococcal surface protein PspC, choline-binding
                     form; NF033838"
                     /db_xref="CDD:468201"
     Region          <414..601
                     /region_name="GKAP"
                     /note="Guanylate-kinase-associated protein (GKAP) protein;
                     pfam03359"
                     /db_xref="CDD:460897"
     CDS             1..842
                     /gene="DLGAP5"
                     /gene_synonym="DLG7; HURP"
                     /coded_by="XM_047432016.1:519..3047"
                     /db_xref="GeneID:9787"
                     /db_xref="HGNC:HGNC:16864"
                     /db_xref="MIM:617859"
ORIGIN      
        1 mssshfasrh rkdistemir tkiahrksls qkenrhkeye rnrhfglkdv niptlegril
       61 veldetsqgl vpektnvkpr amktilgdqr kqmlqkykee kqlqklkeqr ekakrgifkv
      121 gryrpdmpcf llsnqnavka epkkaipssv ritrskakdq meqtkidnes dvrairpgpr
      181 qtsekkvsdk ekkvvqpvmp tslrmtrsat qaakqvprtv ssttarkpvt raanenepeg
      241 kvpskgrpak nvetkpdkgi sckvdseent lnsqtnatsg mnpdgvlskm enlpeintak
      301 ikgknsfapk dfmfqpldgl ktyqvtpmtp rsanafltps ytwtplktev desqatkeil
      361 aqkcktystk tiqqdsnklp cplgpltvwh eehvlnknea ttknlnglpi kevpslerne
      421 griaqphhgv pyfrnilqse tekltshcfe wdrkleldip ddakdlirta vgqtrllmke
      481 rfkqfeglvd dceykrgike ttctdldgfw dmvsfqiedv ihkfnnlikl eesgwqvnnn
      541 mnhnmnknvf rkkvvsgias kpkqddagri aarnrlaaik namrerirqe ecaetavsvi
      601 pkevdkivfd agffrvespv klfsglsvss egpsqrlgtp ksvnkavsqs rnemgipqqt
      661 tspenagpqn tksehvkktl flsipesrss iedaqcpglp dlieenhvvn ktdlkvdcls
      721 sermslplla ggvaddintn kkegisdvve gmelnssits qdvlmsspek ntasqnsile
      781 egetkisqse lfdnksltte chlldsvgsc yvaraglevl gssdpttsas rvagttarsk
      841 lq
//
LOCUS       XP_011535717             823 aa            linear   PRI 05-AUG-2025
DEFINITION  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_011535717
VERSION     XP_011535717.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537415.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..823
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..823
                     /product="apoptosis-resistant E3 ubiquitin protein ligase
                     1 isoform X1"
                     /calculated_mol_wt=94092
     Region          56..154
                     /region_name="Filamin"
                     /note="Filamin/ABP280 repeat; pfam00630"
                     /db_xref="CDD:395505"
     Site            order(468,498,509,577,754,784..785,788..792,812,820)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Region          486..820
                     /region_name="HECTc"
                     /note="Domain Homologous to E6-AP Carboxyl Terminus with;
                     smart00119"
                     /db_xref="CDD:214523"
     Site            order(605,608..609,611..612,615,621,623,627..628,630,636,
                     642,659,663)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..823
                     /gene="AREL1"
                     /gene_synonym="FIEL1; KIAA0317"
                     /coded_by="XM_011537415.3:575..3046"
                     /db_xref="GeneID:9870"
                     /db_xref="HGNC:HGNC:20363"
                     /db_xref="MIM:615380"
ORIGIN      
        1 mfyviggitv svvaffftik flfelaarvv sflqnedrer rgdrtiydyv rgnyldprsc
       61 kvswdwkdpy evghsmafrv hlfykngqpf pahrpvglrv hishvelave ipvtqevlqe
      121 pnsnvvkvaf tvrkagryei tvklgglnva yspyykifqp gmvvpsktki vchfstlvlt
      181 cgqphtlqiv prdeydnptn nsmslrdehn ytlsihelgp qeeestgvsf eksvtsnrqt
      241 fqvflrltlh srgcfhacis yqnqpinnge fdiivlsede knivernvst sgvsiyfeay
      301 lynatncsst pwhlppmhmt ssqrrpstav deededspse chtpekvkkp kkvycyvspk
      361 qfsvkefylk iipwrlytfr vcpgtkfsyl gpdpvhkllt lvvddgiqpp velsckerni
      421 laatfirslh kniggsetfq dkvnffqrel rqvhmkrphs kvtlkvsrha llesslkatr
      481 nfsisdwskn fevvfqdeea ldwggprrew felickalfd ttnqlftrfs dnnqalvhpn
      541 pnrpahlrlk myefagrlvg kclyesslgg aykqlvrarf trsflaqiig lrmhykyfet
      601 ddpefykskv cfilnndmse melvfaeeky nksgqldkvv elmtggaqtp vtnankifyl
      661 nllaqyrlas qvkeevehfl kglnelvpen llaifdenel ellmcgtgdi svsdfkahav
      721 vvggswhfre kvmrwfwtvv ssltqeelar llqfttgssq lppggfaalc psfqiiaapt
      781 hstlptahtc fnqlclptyd syeevhrmlq laisegcegf gml
//
LOCUS       XP_047287974             763 aa            linear   PRI 05-AUG-2025
DEFINITION  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X3 [Homo
            sapiens].
ACCESSION   XP_047287974
VERSION     XP_047287974.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432018.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..763
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..763
                     /product="apoptosis-resistant E3 ubiquitin protein ligase
                     1 isoform X3"
                     /calculated_mol_wt=87149
     Region          56..154
                     /region_name="Filamin"
                     /note="Filamin/ABP280 repeat; pfam00630"
                     /db_xref="CDD:395505"
     Site            order(468,498,509,694,724..725,728..732,752,760)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Region          486..760
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cl27008"
                     /db_xref="CDD:474882"
     Site            order(545,548..549,551..552,555,561,563,567..568,570,576,
                     582,599,603)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..763
                     /gene="AREL1"
                     /gene_synonym="FIEL1; KIAA0317"
                     /coded_by="XM_047432018.1:575..2866"
                     /db_xref="GeneID:9870"
                     /db_xref="HGNC:HGNC:20363"
                     /db_xref="MIM:615380"
ORIGIN      
        1 mfyviggitv svvaffftik flfelaarvv sflqnedrer rgdrtiydyv rgnyldprsc
       61 kvswdwkdpy evghsmafrv hlfykngqpf pahrpvglrv hishvelave ipvtqevlqe
      121 pnsnvvkvaf tvrkagryei tvklgglnva yspyykifqp gmvvpsktki vchfstlvlt
      181 cgqphtlqiv prdeydnptn nsmslrdehn ytlsihelgp qeeestgvsf eksvtsnrqt
      241 fqvflrltlh srgcfhacis yqnqpinnge fdiivlsede knivernvst sgvsiyfeay
      301 lynatncsst pwhlppmhmt ssqrrpstav deededspse chtpekvkkp kkvycyvspk
      361 qfsvkefylk iipwrlytfr vcpgtkfsyl gpdpvhkllt lvvddgiqpp velsckerni
      421 laatfirslh kniggsetfq dkvnffqrel rqvhmkrphs kvtlkvsrha llesslkatr
      481 nfsisdwskn fevvfqdeea ldwggprrew felickalfd ttnqlftrfs dnnqalyfet
      541 ddpefykskv cfilnndmse melvfaeeky nksgqldkvv elmtggaqtp vtnankifyl
      601 nllaqyrlas qvkeevehfl kglnelvpen llaifdenel ellmcgtgdi svsdfkahav
      661 vvggswhfre kvmrwfwtvv ssltqeelar llqfttgssq lppggfaalc psfqiiaapt
      721 hstlptahtc fnqlclptyd syeevhrmlq laisegcegf gml
//
LOCUS       XP_047287975             753 aa            linear   PRI 05-AUG-2025
DEFINITION  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X4 [Homo
            sapiens].
ACCESSION   XP_047287975
VERSION     XP_047287975.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432019.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..753
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..753
                     /product="apoptosis-resistant E3 ubiquitin protein ligase
                     1 isoform X4"
                     /calculated_mol_wt=86026
     Region          56..144
                     /region_name="Filamin"
                     /note="Filamin/ABP280 repeat; pfam00630"
                     /db_xref="CDD:395505"
     Site            order(458,488,499,684,714..715,718..722,742,750)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Region          476..750
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cl27008"
                     /db_xref="CDD:474882"
     Site            order(535,538..539,541..542,545,551,553,557..558,560,566,
                     572,589,593)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..753
                     /gene="AREL1"
                     /gene_synonym="FIEL1; KIAA0317"
                     /coded_by="XM_047432019.1:482..2743"
                     /db_xref="GeneID:9870"
                     /db_xref="HGNC:HGNC:20363"
                     /db_xref="MIM:615380"
ORIGIN      
        1 mfyviggitv svvaffftik flfelaarvv sflqnedrer rgdrtiydyv rgnyldprsc
       61 kvswdwkdpy elfykngqpf pahrpvglrv hishvelave ipvtqevlqe pnsnvvkvaf
      121 tvrkagryei tvklgglnva yspyykifqp gmvvpsktki vchfstlvlt cgqphtlqiv
      181 prdeydnptn nsmslrdehn ytlsihelgp qeeestgvsf eksvtsnrqt fqvflrltlh
      241 srgcfhacis yqnqpinnge fdiivlsede knivernvst sgvsiyfeay lynatncsst
      301 pwhlppmhmt ssqrrpstav deededspse chtpekvkkp kkvycyvspk qfsvkefylk
      361 iipwrlytfr vcpgtkfsyl gpdpvhkllt lvvddgiqpp velsckerni laatfirslh
      421 kniggsetfq dkvnffqrel rqvhmkrphs kvtlkvsrha llesslkatr nfsisdwskn
      481 fevvfqdeea ldwggprrew felickalfd ttnqlftrfs dnnqalyfet ddpefykskv
      541 cfilnndmse melvfaeeky nksgqldkvv elmtggaqtp vtnankifyl nllaqyrlas
      601 qvkeevehfl kglnelvpen llaifdenel ellmcgtgdi svsdfkahav vvggswhfre
      661 kvmrwfwtvv ssltqeelar llqfttgssq lppggfaalc psfqiiaapt hstlptahtc
      721 fnqlclptyd syeevhrmlq laisegcegf gml
//
LOCUS       XP_005268301             662 aa            linear   PRI 05-AUG-2025
DEFINITION  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X5 [Homo
            sapiens].
ACCESSION   XP_005268301
VERSION     XP_005268301.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005268244.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..662
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..662
                     /product="apoptosis-resistant E3 ubiquitin protein ligase
                     1 isoform X5"
                     /calculated_mol_wt=75530
     Site            order(307,337,348,416,593,623..624,627..631,651,659)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Region          325..659
                     /region_name="HECTc"
                     /note="Domain Homologous to E6-AP Carboxyl Terminus with;
                     smart00119"
                     /db_xref="CDD:214523"
     Site            order(444,447..448,450..451,454,460,462,466..467,469,475,
                     481,498,502)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..662
                     /gene="AREL1"
                     /gene_synonym="FIEL1; KIAA0317"
                     /coded_by="XM_005268244.4:738..2726"
                     /db_xref="GeneID:9870"
                     /db_xref="HGNC:HGNC:20363"
                     /db_xref="MIM:615380"
ORIGIN      
        1 mvvpsktkiv chfstlvltc gqphtlqivp rdeydnptnn smslrdehny tlsihelgpq
       61 eeestgvsfe ksvtsnrqtf qvflrltlhs rgcfhacisy qnqpinngef diivlsedek
      121 nivernvsts gvsiyfeayl ynatncsstp whlppmhmts sqrrpstavd eededspsec
      181 htpekvkkpk kvycyvspkq fsvkefylki ipwrlytfrv cpgtkfsylg pdpvhklltl
      241 vvddgiqppv elsckernil aatfirslhk niggsetfqd kvnffqrelr qvhmkrphsk
      301 vtlkvsrhal lesslkatrn fsisdwsknf evvfqdeeal dwggprrewf elickalfdt
      361 tnqlftrfsd nnqalvhpnp nrpahlrlkm yefagrlvgk clyesslgga ykqlvrarft
      421 rsflaqiigl rmhykyfetd dpefykskvc filnndmsem elvfaeekyn ksgqldkvve
      481 lmtggaqtpv tnankifyln llaqyrlasq vkeevehflk glnelvpenl laifdenele
      541 llmcgtgdis vsdfkahavv vggswhfrek vmrwfwtvvs sltqeelarl lqfttgssql
      601 ppggfaalcp sfqiiaapth stlptahtcf nqlclptyds yeevhrmlql aisegcegfg
      661 ml
//
LOCUS       XP_047287976             546 aa            linear   PRI 05-AUG-2025
DEFINITION  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X6 [Homo
            sapiens].
ACCESSION   XP_047287976
VERSION     XP_047287976.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432020.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..546
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..546
                     /product="apoptosis-resistant E3 ubiquitin protein ligase
                     1 isoform X6"
                     /calculated_mol_wt=62642
     Region          56..154
                     /region_name="Filamin"
                     /note="Filamin/ABP280 repeat; pfam00630"
                     /db_xref="CDD:395505"
     Region          464..>542
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cl27008"
                     /db_xref="CDD:474882"
     CDS             1..546
                     /gene="AREL1"
                     /gene_synonym="FIEL1; KIAA0317"
                     /coded_by="XM_047432020.1:482..2122"
                     /db_xref="GeneID:9870"
                     /db_xref="HGNC:HGNC:20363"
                     /db_xref="MIM:615380"
ORIGIN      
        1 mfyviggitv svvaffftik flfelaarvv sflqnedrer rgdrtiydyv rgnyldprsc
       61 kvswdwkdpy evghsmafrv hlfykngqpf pahrpvglrv hishvelave ipvtqevlqe
      121 pnsnvvkvaf tvrkagryei tvklgglnva yspyykifqp gmvvpsktki vchfstlvlt
      181 cgqphtlqiv prdeydnptn nsmslrdehn ytlsihelgp qeeestgvsf eksvtsnrqt
      241 fqvflrltlh srgcfhacis yqnqpinnge fdiivlsede knivernvst sgvsiyfeay
      301 lynatncsst pwhlppmhmt ssqrrpstav deededspse chtpekvkkp kkvycyvspk
      361 qfsvkefylk iipwrlytfr vcpgtkfsyl gpdpvhkllt lvvddgiqpp velsckerni
      421 laatfirslh kniggsetfq dkvnffqrel rqvhmkrphs kvtlkvsrha llesslkatr
      481 nfsisdwskn fevvfqdeea ldwggprrew felickalfd ttnqlftrfs dnnqalslsw
      541 tgasqp
//
LOCUS       XP_047287977             731 aa            linear   PRI 05-AUG-2025
DEFINITION  golgin subfamily A member 5 isoform X1 [Homo sapiens].
ACCESSION   XP_047287977
VERSION     XP_047287977.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432021.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..731
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..731
                     /product="golgin subfamily A member 5 isoform X1"
                     /calculated_mol_wt=82894
     Region          <219..570
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          420..724
                     /region_name="Golgin_A5"
                     /note="Golgin subfamily A member 5; pfam09787"
                     /db_xref="CDD:462900"
     CDS             1..731
                     /gene="GOLGA5"
                     /gene_synonym="GOLIM5; ret-II; RFG5"
                     /coded_by="XM_047432021.1:720..2915"
                     /db_xref="GeneID:9950"
                     /db_xref="HGNC:HGNC:4428"
                     /db_xref="MIM:606918"
ORIGIN      
        1 mswfvdlagk aedllnrvdq gaatalsrkd nasniysknt dytelhqqnt dliyqtgpks
       61 tyissaadni rnqkatilag tanvkvgsrt pveashpven asvprpsshf vrrkksepdd
      121 ellfdflnss qkeptgrvei rkekgktpvf qssqtssvss vnpsvttikt ieensfgsqt
      181 heaasnsdss hegqeesske nvssnaacpd htptpnddgk shelsnlrle nqllrnevqs
      241 lnqemasllq rsketqeeln kararvekwn adhsksdrmt rglraqvddl teavaakdsq
      301 lavlkvrlqe adqllstrte alealqseks rimqdqsegn slqnqalqtf qerlheadat
      361 lkreqesykq mqsefaarln kvemerqnla eaitlaerky sdekkrvdel qqqvklykln
      421 lesskqelid ykqkatrilq skeklinslk egsgfeglds stassmelee lrhekemqre
      481 eiqklmgqih qlrselqdme aqqvneaesa reqlqdlhdq iagqkaskqe letelerlkq
      541 efhyieedly rtkntlqsri kdrdeeiqkl rnqltnktls nssqselenr lhqltetliq
      601 kqtmleslst eknslvfqle rleqqmnsas gsssngssin msgidngegt rlrnvpvlfn
      661 dtetnlagmy gkvrkaassi dqfsirlgif lrrypiarvf viiymallhl wvmivlltyt
      721 pemhhdqpyg k
//
LOCUS       XP_011535722             691 aa            linear   PRI 05-AUG-2025
DEFINITION  golgin subfamily A member 5 isoform X2 [Homo sapiens].
ACCESSION   XP_011535722
VERSION     XP_011535722.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537420.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..691
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..691
                     /product="golgin subfamily A member 5 isoform X2"
                     /calculated_mol_wt=77977
     Region          <227..>542
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          420..683
                     /region_name="Golgin_A5"
                     /note="Golgin subfamily A member 5; pfam09787"
                     /db_xref="CDD:462900"
     CDS             1..691
                     /gene="GOLGA5"
                     /gene_synonym="GOLIM5; ret-II; RFG5"
                     /coded_by="XM_011537420.4:183..2258"
                     /db_xref="GeneID:9950"
                     /db_xref="HGNC:HGNC:4428"
                     /db_xref="MIM:606918"
ORIGIN      
        1 mswfvdlagk aedllnrvdq gaatalsrkd nasniysknt dytelhqqnt dliyqtgpks
       61 tyissaadni rnqkatilag tanvkvgsrt pveashpven asvprpsshf vrrkksepdd
      121 ellfdflnss qkeptgrvei rkekgktpvf qssqtssvss vnpsvttikt ieensfgsqt
      181 heaasnsdss hegqeesske nvssnaacpd htptpnddgk shelsnlrle nqllrnevqs
      241 lnqemasllq rsketqeeln kararvekwn adhsksdrmt rglraqvddl teavaakdsq
      301 lavlkvrlqe adqllstrte alealqseks rimqdqsegn slqnqalqtf qerlheadat
      361 lkreqesykq mqsefaarln kvemerqnla eaitlaerky sdekkrvdel qqqvklykln
      421 lesskqelid ykqkatrilq skeklinslk egsgfeglds stassmelee lrhekemqre
      481 eiqklmgqih qlrselqdme aqqvneaesa reqlqdlhdq iagqkaskqe letelerlkq
      541 efhyieedly rtkntlqsri kdrdeeiqkl rnqltnktls nssqselenr lhqltetliq
      601 kqtmleslst eknslvfqle rleqqmnsas gsssngssin msgidngegt rlrnvpvlfn
      661 dtetnlagmy gkvrkaassi dqfrlcftsg s
//
LOCUS       XP_024305562             639 aa            linear   PRI 05-AUG-2025
DEFINITION  meiotic recombination protein REC8 homolog isoform X1 [Homo
            sapiens].
ACCESSION   XP_024305562
VERSION     XP_024305562.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449794.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..639
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..639
                     /product="meiotic recombination protein REC8 homolog
                     isoform X1"
                     /calculated_mol_wt=72552
     Region          1..113
                     /region_name="Rad21_Rec8_N"
                     /note="N terminus of Rad21 / Rec8 like protein; pfam04825"
                     /db_xref="CDD:461446"
     Region          306..373
                     /region_name="Rad21_Rec8_M_Rec8"
                     /note="Middle HEAT-repeat binding domain found in Homo
                     sapiens meiotic recombination protein REC8 homolog and
                     similar proteins; cd21794"
                     /db_xref="CDD:439296"
     Site            order(306,309..316,319,322..323,328..335,345,348..353,
                     365..366,368..373)
                     /site_type="other"
                     /note="putative HEAT-repeat binding site [polypeptide
                     binding]"
                     /db_xref="CDD:439296"
     Region          492..>519
                     /region_name="Rad21_Rec8"
                     /note="Conserved region of Rad21 / Rec8 like protein;
                     pfam04824"
                     /db_xref="CDD:335912"
     CDS             1..639
                     /gene="REC8"
                     /gene_synonym="HR21spB; REC8L1; Rec8p"
                     /coded_by="XM_024449794.2:373..2292"
                     /db_xref="GeneID:9985"
                     /db_xref="HGNC:HGNC:16879"
                     /db_xref="MIM:608193"
ORIGIN      
        1 mfyypnvlqr htgcfatiwl aatrgsrlvk reylrvnvvk tceeilnyvl vrvqppqpgl
       61 prprfslyls aqlqigvirv ysqqcqylve diqhilerlh raqlqiridm etelpslllp
      121 nhlammetle dapdpffgmm svdprlpspf dipqirhlle aaiperveei ppevptepre
      181 peripvtvlp peaitileae pirmleiege relpevsrre ldlliaeeee ailleiprlp
      241 ppapaevegi gealgpeelr ltgwepgall mevtppeelr lpappsperr ppvpppprrr
      301 rrrrllfwdk etqispekfq eqlqtrahcw ecpmvqpper tirgpaelfr tptlsgwlpp
      361 ellglwthca qpppkalrre lpeeaaaeee rrkievpsei evprealeps vplmvsleis
      421 leaaeeeksr islippeerw awpeveapea palpvvpelp evpmemplvl ppelellsle
      481 avhravalel qanrepdfss lvsplsprrm aarvfylllg ecmhvcvcmw grdtetrgpy
      541 rdspdlpspr lltsalsatd ssretrkaiw sppdpagaqi plrlesiyka arkpatsskp
      601 rraslgpayl isecafpafl lsellfkqkt scfyysmms
//
LOCUS       XP_011535723             639 aa            linear   PRI 05-AUG-2025
DEFINITION  meiotic recombination protein REC8 homolog isoform X1 [Homo
            sapiens].
ACCESSION   XP_011535723
VERSION     XP_011535723.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537421.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..639
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..639
                     /product="meiotic recombination protein REC8 homolog
                     isoform X1"
                     /calculated_mol_wt=72552
     Region          1..113
                     /region_name="Rad21_Rec8_N"
                     /note="N terminus of Rad21 / Rec8 like protein; pfam04825"
                     /db_xref="CDD:461446"
     Region          306..373
                     /region_name="Rad21_Rec8_M_Rec8"
                     /note="Middle HEAT-repeat binding domain found in Homo
                     sapiens meiotic recombination protein REC8 homolog and
                     similar proteins; cd21794"
                     /db_xref="CDD:439296"
     Site            order(306,309..316,319,322..323,328..335,345,348..353,
                     365..366,368..373)
                     /site_type="other"
                     /note="putative HEAT-repeat binding site [polypeptide
                     binding]"
                     /db_xref="CDD:439296"
     Region          492..>519
                     /region_name="Rad21_Rec8"
                     /note="Conserved region of Rad21 / Rec8 like protein;
                     pfam04824"
                     /db_xref="CDD:335912"
     CDS             1..639
                     /gene="REC8"
                     /gene_synonym="HR21spB; REC8L1; Rec8p"
                     /coded_by="XM_011537421.3:474..2393"
                     /db_xref="GeneID:9985"
                     /db_xref="HGNC:HGNC:16879"
                     /db_xref="MIM:608193"
ORIGIN      
        1 mfyypnvlqr htgcfatiwl aatrgsrlvk reylrvnvvk tceeilnyvl vrvqppqpgl
       61 prprfslyls aqlqigvirv ysqqcqylve diqhilerlh raqlqiridm etelpslllp
      121 nhlammetle dapdpffgmm svdprlpspf dipqirhlle aaiperveei ppevptepre
      181 peripvtvlp peaitileae pirmleiege relpevsrre ldlliaeeee ailleiprlp
      241 ppapaevegi gealgpeelr ltgwepgall mevtppeelr lpappsperr ppvpppprrr
      301 rrrrllfwdk etqispekfq eqlqtrahcw ecpmvqpper tirgpaelfr tptlsgwlpp
      361 ellglwthca qpppkalrre lpeeaaaeee rrkievpsei evprealeps vplmvsleis
      421 leaaeeeksr islippeerw awpeveapea palpvvpelp evpmemplvl ppelellsle
      481 avhravalel qanrepdfss lvsplsprrm aarvfylllg ecmhvcvcmw grdtetrgpy
      541 rdspdlpspr lltsalsatd ssretrkaiw sppdpagaqi plrlesiyka arkpatsskp
      601 rraslgpayl isecafpafl lsellfkqkt scfyysmms
//
LOCUS       XP_016877330             372 aa            linear   PRI 05-AUG-2025
DEFINITION  meiotic recombination protein REC8 homolog isoform X2 [Homo
            sapiens].
ACCESSION   XP_016877330
VERSION     XP_016877330.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021841.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..372
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..372
                     /product="meiotic recombination protein REC8 homolog
                     isoform X2"
                     /calculated_mol_wt=42243
     Region          39..106
                     /region_name="Rad21_Rec8_M_Rec8"
                     /note="Middle HEAT-repeat binding domain found in Homo
                     sapiens meiotic recombination protein REC8 homolog and
                     similar proteins; cd21794"
                     /db_xref="CDD:439296"
     Site            order(39,42..49,52,55..56,61..68,78,81..86,98..99,
                     101..106)
                     /site_type="other"
                     /note="putative HEAT-repeat binding site [polypeptide
                     binding]"
                     /db_xref="CDD:439296"
     Region          225..>252
                     /region_name="Rad21_Rec8"
                     /note="Conserved region of Rad21 / Rec8 like protein;
                     pfam04824"
                     /db_xref="CDD:335912"
     CDS             1..372
                     /gene="REC8"
                     /gene_synonym="HR21spB; REC8L1; Rec8p"
                     /coded_by="XM_017021841.3:83..1201"
                     /db_xref="GeneID:9985"
                     /db_xref="HGNC:HGNC:16879"
                     /db_xref="MIM:608193"
ORIGIN      
        1 mplstphriw ptlprwvplc krrppvpppp rrrrrrrllf wdketqispe kfqeqlqtra
       61 hcwecpmvqp pertirgpae lfrtptlsgw lppellglwt hcaqpppkal rrelpeeaaa
      121 eeerrkievp seievpreal epsvplmvsl eisleaaeee ksrislippe erwawpevea
      181 peapalpvvp elpevpmemp lvlppelell sleavhrava lelqanrepd fsslvsplsp
      241 rrmaarvfyl llgecmhvcv cmwgrdtetr gpyrdspdlp sprlltsals atdssretrk
      301 aiwsppdpag aqiplrlesi ykaarkpats skprraslgp aylisecafp afllsellfk
      361 qktscfyysm ms
//
LOCUS       XP_047287978             316 aa            linear   PRI 05-AUG-2025
DEFINITION  meiotic recombination protein REC8 homolog isoform X3 [Homo
            sapiens].
ACCESSION   XP_047287978
VERSION     XP_047287978.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432022.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..316
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..316
                     /product="meiotic recombination protein REC8 homolog
                     isoform X3"
                     /calculated_mol_wt=35502
     Region          1..113
                     /region_name="Rad21_Rec8_N"
                     /note="N terminus of Rad21 / Rec8 like protein; pfam04825"
                     /db_xref="CDD:461446"
     CDS             1..316
                     /gene="REC8"
                     /gene_synonym="HR21spB; REC8L1; Rec8p"
                     /coded_by="XM_047432022.1:373..1323"
                     /db_xref="GeneID:9985"
                     /db_xref="HGNC:HGNC:16879"
                     /db_xref="MIM:608193"
ORIGIN      
        1 mfyypnvlqr htgcfatiwl aatrgsrlvk reylrvnvvk tceeilnyvl vrvqppqpgl
       61 prprfslyls aqlqigvirv ysqqcqylve diqhilerlh raqlqiridm etelpslllp
      121 nhlammetle dapdpffgmm svdprlpspf dipqirhlle aaiperveei ppevptepre
      181 peripvtvlp peaitileae pirmleiege relpevsrre ldlliaeeee ailleiprlp
      241 ppapaevegi gealgpeelr ltgwepgall mevtppeelr lpappspevs slpsnppppp
      301 lcpppqglpp qaqghc
//
LOCUS       XP_047287979             281 aa            linear   PRI 05-AUG-2025
DEFINITION  meiotic recombination protein REC8 homolog isoform X4 [Homo
            sapiens].
ACCESSION   XP_047287979
VERSION     XP_047287979.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432023.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..281
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..281
                     /product="meiotic recombination protein REC8 homolog
                     isoform X4"
                     /calculated_mol_wt=31856
     Region          1..113
                     /region_name="Rad21_Rec8_N"
                     /note="N terminus of Rad21 / Rec8 like protein; pfam04825"
                     /db_xref="CDD:461446"
     CDS             1..281
                     /gene="REC8"
                     /gene_synonym="HR21spB; REC8L1; Rec8p"
                     /coded_by="XM_047432023.1:373..1218"
                     /db_xref="GeneID:9985"
                     /db_xref="HGNC:HGNC:16879"
                     /db_xref="MIM:608193"
ORIGIN      
        1 mfyypnvlqr htgcfatiwl aatrgsrlvk reylrvnvvk tceeilnyvl vrvqppqpgl
       61 prprfslyls aqlqigvirv ysqqcqylve diqhilerlh raqlqiridm etelpslllp
      121 nhlammetle dapdpffgmm svdprlpspf dipqirhlle aaiperveei ppevptepre
      181 peripvtvlp peaitileae pirmleiege relpevsrre ldlliaeeee ailleiprlp
      241 ppapaevegi gealgpeelr ltgwepgall mglppqaqgh c
//
LOCUS       XP_047287980             280 aa            linear   PRI 05-AUG-2025
DEFINITION  meiotic recombination protein REC8 homolog isoform X5 [Homo
            sapiens].
ACCESSION   XP_047287980
VERSION     XP_047287980.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432024.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..280
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..280
                     /product="meiotic recombination protein REC8 homolog
                     isoform X5"
                     /calculated_mol_wt=32174
     Region          39..106
                     /region_name="Rad21_Rec8_M_Rec8"
                     /note="Middle HEAT-repeat binding domain found in Homo
                     sapiens meiotic recombination protein REC8 homolog and
                     similar proteins; cd21794"
                     /db_xref="CDD:439296"
     Site            order(39,42..49,52,55..56,61..68,78,81..86,98..99,
                     101..106)
                     /site_type="other"
                     /note="putative HEAT-repeat binding site [polypeptide
                     binding]"
                     /db_xref="CDD:439296"
     Region          225..279
                     /region_name="Rad21_Rec8"
                     /note="Conserved region of Rad21 / Rec8 like protein;
                     pfam04824"
                     /db_xref="CDD:335912"
     CDS             1..280
                     /gene="REC8"
                     /gene_synonym="HR21spB; REC8L1; Rec8p"
                     /coded_by="XM_047432024.1:143..985"
                     /db_xref="GeneID:9985"
                     /db_xref="HGNC:HGNC:16879"
                     /db_xref="MIM:608193"
ORIGIN      
        1 mplstphriw ptlprwvplc krrppvpppp rrrrrrrllf wdketqispe kfqeqlqtra
       61 hcwecpmvqp pertirgpae lfrtptlsgw lppellglwt hcaqpppkal rrelpeeaaa
      121 eeerrkievp seievpreal epsvplmvsl eisleaaeee ksrislippe erwawpevea
      181 peapalpvvp elpevpmemp lvlppelell sleavhrava lelqanrepd fsslvsplsp
      241 rrmaarvfyl llvlsaqqil hvkqekpygr lliqpgprfh
//
LOCUS       XP_047287981              97 aa            linear   PRI 05-AUG-2025
DEFINITION  translation machinery-associated protein 7-like [Homo sapiens].
ACCESSION   XP_047287981
VERSION     XP_047287981.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432025.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 37% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..97
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..97
                     /product="translation machinery-associated protein 7-like"
                     /calculated_mol_wt=10553
     Region          3..61
                     /region_name="TMA7"
                     /note="Translation machinery associated TMA7; pfam09072"
                     /db_xref="CDD:462671"
     CDS             1..97
                     /gene="LOC124903276"
                     /coded_by="XM_047432025.1:1..294"
                     /db_xref="GeneID:124903276"
ORIGIN      
        1 msgheggkkk slkqpkkqak ktdgdkafkq kqkeeqkkfe glkakamgkg plttggikks
       61 gnwlgmvaht ciycvhriev dlplnnsfsq lspkdis
//
LOCUS       XP_047287991             158 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein LOC124903317 [Homo sapiens].
ACCESSION   XP_047287991
VERSION     XP_047287991.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432035.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..158
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..158
                     /product="uncharacterized protein LOC124903317"
                     /calculated_mol_wt=16681
     CDS             1..158
                     /gene="LOC124903317"
                     /coded_by="XM_047432035.1:1720..2196"
                     /db_xref="GeneID:124903317"
ORIGIN      
        1 miearflgfr kstkiargeg ascncssqal raprqlgarl gdtpldaasg aartlqrpag
       61 lrslpqnllq lgvlspsrrr sapslsldlr agsllpppal svrgsqppar gqrvqpktpq
      121 ffpttplpra slvsallprt sqsvweqcnl nknvvsig
//
LOCUS       XP_047287992             115 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein LOC124903319 [Homo sapiens].
ACCESSION   XP_047287992
VERSION     XP_047287992.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432036.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..115
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..115
                     /product="uncharacterized protein LOC124903319"
                     /calculated_mol_wt=12606
     CDS             1..115
                     /gene="LOC124903319"
                     /coded_by="XM_047432036.1:206..553"
                     /db_xref="GeneID:124903319"
ORIGIN      
        1 mtvlenatgg gqnmvdpgks eltvgqdelp rregaaqpql prkdfplsss qlisadrlal
       61 lflyhgrmcl aprltwcrcs htyqlthnps gaqtqafrsq lkyhllgeis adhtc
//
LOCUS       XP_047287998             141 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein LOC124903372 [Homo sapiens].
ACCESSION   XP_047287998
VERSION     XP_047287998.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432042.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..141
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..141
                     /product="uncharacterized protein LOC124903372"
                     /calculated_mol_wt=15724
     CDS             1..141
                     /gene="LOC124903372"
                     /coded_by="XM_047432042.1:211..636"
                     /db_xref="GeneID:124903372"
ORIGIN      
        1 meprvtqrkr pldgcmgkit gitsdilkyd hkcfklslpa kfpevcgsde vfpdpdllhv
       61 lpvagslqqs idqcclqles lcrpgllcah ptllfklhss mknrpffsli ytyvkktqqv
      121 rkrdrkprgq vaagpnptsv m
//
LOCUS       XP_047287999             308 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein LOC124903391 [Homo sapiens].
ACCESSION   XP_047287999
VERSION     XP_047287999.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432043.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..308
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..308
                     /product="uncharacterized protein LOC124903391"
                     /calculated_mol_wt=32952
     CDS             1..308
                     /gene="LOC124903391"
                     /coded_by="XM_047432043.1:854..1780"
                     /db_xref="GeneID:124903391"
ORIGIN      
        1 mnlsdslvcw alagrhlgrd qglrlahrqr ehlvhppldl grdpreragp lagprhqhla
       61 lgvpvglgah qhqqdgpgfp qpaqalaqrp hgrerglaah apehreavav advqvlerdq
      121 vlgvrrvhdf qqrgrrvcld llaepllrpr rallgerpha ncvssvvlpt srspaahpgs
      181 pggardqpav sgtrrggeer eegegkeege gawerrerrt rtvragagrg eeggdgggqe
      241 rrkeeegrgg etrgqgvagl aspvargrgg rlldllppgl ippgaaptpl srcsrtklrv
      301 grlflgaq
//
LOCUS       XP_047288000             308 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein LOC124903391 [Homo sapiens].
ACCESSION   XP_047288000
VERSION     XP_047288000.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432044.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..308
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..308
                     /product="uncharacterized protein LOC124903391"
                     /calculated_mol_wt=32952
     CDS             1..308
                     /gene="LOC124903391"
                     /coded_by="XM_047432044.1:854..1780"
                     /db_xref="GeneID:124903391"
ORIGIN      
        1 mnlsdslvcw alagrhlgrd qglrlahrqr ehlvhppldl grdpreragp lagprhqhla
       61 lgvpvglgah qhqqdgpgfp qpaqalaqrp hgrerglaah apehreavav advqvlerdq
      121 vlgvrrvhdf qqrgrrvcld llaepllrpr rallgerpha ncvssvvlpt srspaahpgs
      181 pggardqpav sgtrrggeer eegegkeege gawerrerrt rtvragagrg eeggdgggqe
      241 rrkeeegrgg etrgqgvagl aspvargrgg rlldllppgl ippgaaptpl srcsrtklrv
      301 grlflgaq
//
LOCUS       XP_047288001             102 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein LOC124903401 [Homo sapiens].
ACCESSION   XP_047288001
VERSION     XP_047288001.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432045.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..102
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..102
                     /product="uncharacterized protein LOC124903401"
                     /calculated_mol_wt=11589
     CDS             1..102
                     /gene="LOC124903401"
                     /coded_by="XM_047432045.1:72..380"
                     /db_xref="GeneID:124903401"
ORIGIN      
        1 metppppslp fqllcirqpr ylqgllshsr hlktqqdqpl pflllfnlln lksmmktfvm
       61 ihihlmkarq gtstegcdlt dgamvtqsev fcygslnrpr hq
//
LOCUS       XP_011535754             242 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein LOC105370706, partial [Homo sapiens].
ACCESSION   XP_011535754
VERSION     XP_011535754.3
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011537452.3
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XP_011535754.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 23% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: incomplete on the carboxy end.
FEATURES             Location/Qualifiers
     source          1..242
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..>242
                     /product="uncharacterized protein LOC105370706"
     CDS             1..242
                     /gene="LOC105370706"
                     /coded_by="XM_011537452.3:1..>726"
                     /db_xref="GeneID:105370706"
ORIGIN      
        1 maggqpisrr staqigshqy pflatpfskl ltqlallppq prlplsfyaa iqsslrqfri
       61 yythcylnth rkllssprpl qsisrahiiv rplfsslqpm frayrayhvy yitirhkpkq
      121 laagllniat aeifsgleee plqmstnfsn flvygmkslk ltalcstigl hdargrvgkk
      181 varslvvgih rlplkgvlpg wrmlleekre rhetgtlqsc hhgnvtqwhr acssllfsfl
      241 ff
//
LOCUS       XP_047288002             273 aa            linear   PRI 05-AUG-2025
DEFINITION  translation initiation factor IF-2-like [Homo sapiens].
ACCESSION   XP_047288002
VERSION     XP_047288002.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432046.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 12% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..273
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..273
                     /product="translation initiation factor IF-2-like"
                     /calculated_mol_wt=28663
     Region          <61..256
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..273
                     /gene="LOC124903404"
                     /coded_by="XM_047432046.1:1..822"
                     /db_xref="GeneID:124903404"
ORIGIN      
        1 mtrlgtislt vavsrfnleg asntsvreiq kppgisrfsp pranhglrlp rlweqvsraa
       61 apagraqvpv parrplpaar gpgpgagaqv paprcaghga aaplgirqra plqqlagrga
      121 erlrelgqll algparrrel rlgaaflqpp eppgaegtdr pprtladrgg qrrasgerlg
      181 arrarparsa pgtpcaprvp apcdpprvla gpglrsslae plrspprklg krrrgcgerr
      241 gdgldfpsap krlpvpgslg fssfimnlaq gwl
//
LOCUS       XP_047288003             130 aa            linear   PRI 05-AUG-2025
DEFINITION  proline-rich protein 2-like [Homo sapiens].
ACCESSION   XP_047288003
VERSION     XP_047288003.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432047.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 19% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..130
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..130
                     /product="proline-rich protein 2-like"
                     /calculated_mol_wt=13461
     CDS             1..130
                     /gene="LOC124903405"
                     /coded_by="XM_047432047.1:1..393"
                     /db_xref="GeneID:124903405"
ORIGIN      
        1 mkqllqflps hgppppprir ppgsgggtpg pgrpaapaar pasvrrsvrp patprphgas
       61 lcgaprrpvp ppglaprrrh rrtlprgmvc epgfwrqevr raspmsaprp glacgcgcgg
      121 raagpreagr
//
LOCUS       XP_047288004             273 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein LOC124903406 [Homo sapiens].
ACCESSION   XP_047288004
VERSION     XP_047288004.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432048.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 23% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..273
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..273
                     /product="uncharacterized protein LOC124903406"
                     /calculated_mol_wt=29957
     Region          <65..234
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..273
                     /gene="LOC124903406"
                     /coded_by="XM_047432048.1:1..822"
                     /db_xref="GeneID:124903406"
ORIGIN      
        1 mellkpdlqv ewapfrweda hvsiplrvqi rshtpgrvip egraglcara gagcvwrgqs
       61 alsrprraha drlsvppags asttqicapw wehrspgsal rtpsvyprrp aqeagprarr
      121 ratgwsrrsw qphgstccsv garppekaer gadlcsarrl agqgrgcqea reqsrrsgae
      181 ralpgspsaq rmrsvgarpe vgalgrrspr tplstaplsv rppwtpsipk prqpirrlgr
      241 pqaqrdtttt trrhhrrstw ggtykasrlt pvs
//
LOCUS       XP_047288005             556 aa            linear   PRI 05-AUG-2025
DEFINITION  mucin-2-like [Homo sapiens].
ACCESSION   XP_047288005
VERSION     XP_047288005.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432049.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 32% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..556
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..556
                     /product="mucin-2-like"
                     /calculated_mol_wt=60121
     Region          <176..545
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..556
                     /gene="LOC124903407"
                     /coded_by="XM_047432049.1:1..1671"
                     /db_xref="GeneID:124903407"
ORIGIN      
        1 maenkglgyp darfsvlvss qlaipmplls sgspvllcdp gpwpthlraa vlyiptpcsl
       61 qnptalqatn pkigcssele kpywrggvpk asslpsflgd cglvmmcglg ldlyceeeet
      121 ewapqqgiwk apfllltvtp ngmfpnpqni waaelralll aqptgcslls lawttphldh
      181 tpssphpiqa tlhpvhtpsr phpiqstlht vhapsrphpi qstlhpvhsl srphpiqstp
      241 hpdhtpsspc piqtthhlvh apsrphtiqt ttpssphciq tsvhlssphl tqtnlhpvht
      301 pssphpikit tpssphsils tphpvhtpss phpvqytphp vhtpsrphpi qytphpvhtp
      361 sslhsiqttp hsvhvassph piqttphpdh tpssphpiqs tphpdhtvss prpiqtiphp
      421 dhtsprpstp hpdhtpsrph ltqttphpvt lhpvhtpsrp llhpdhtpcs shspkstphp
      481 vhvpssscpt qttlhpihap prpllhpvht asspysiqst vhpdhvhlth apsspcsiws
      541 saftlqcpll sslfla
//
LOCUS       XP_047288006             283 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein LOC124903408 [Homo sapiens].
ACCESSION   XP_047288006
VERSION     XP_047288006.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432050.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000014.9) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 9% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..283
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
     Protein         1..283
                     /product="uncharacterized protein LOC124903408"
                     /calculated_mol_wt=31026
     CDS             1..283
                     /gene="LOC124903408"
                     /coded_by="XM_047432050.1:1..852"
                     /db_xref="GeneID:124903408"
ORIGIN      
        1 mcldlqggcn sawpigstmk thsvgqqttp erlkkvgsqg lpaqacchgq npgghrvprq
       61 wpqhcalppg vlaclcgagd wesracdlrp pslrvevttl dqglpqlvae drqeyvwhsc
      121 gpllgtqalp paplplegqp whghgglppg tsptqyinew vwlfqencvy thrcarpgrr
      181 alvcrplfet sgsqmctcis itqsgvrvwt pgphaellsg awalhfhrfq vlllerrprs
      241 ehpaleeemq krqaglqksl srlacwlcsn anpserpsla tll
//
LOCUS       XP_011519450             797 aa            linear   PRI 05-AUG-2025
DEFINITION  potassium/sodium hyperpolarization-activated cyclic
            nucleotide-gated channel 4 isoform X1 [Homo sapiens].
ACCESSION   XP_011519450
VERSION     XP_011519450.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521148.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..797
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..797
                     /product="potassium/sodium hyperpolarization-activated
                     cyclic nucleotide-gated channel 4 isoform X1"
                     /calculated_mol_wt=84334
     Region          <10..>334
                     /region_name="PLN03192"
                     /note="Voltage-dependent potassium channel; Provisional"
                     /db_xref="CDD:215625"
     Region          189..297
                     /region_name="CAP_ED"
                     /note="effector domain of the CAP family of transcription
                     factors; members include CAP (or cAMP receptor protein
                     (CRP)), which binds cAMP, FNR (fumarate and nitrate
                     reduction), which uses an iron-sulfur cluster to sense
                     oxygen) and CooA, a heme containing CO...; cd00038"
                     /db_xref="CDD:237999"
     Site            order(253..254,263..265)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:237999"
     Site            order(285..287,291..293)
                     /site_type="other"
                     /note="flexible hinge region"
                     /db_xref="CDD:237999"
     Region          <360..638
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          <522..794
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..797
                     /gene="HCN4"
                     /gene_synonym="BRGDA8; EIG18; SSS2"
                     /coded_by="XM_011521148.3:430..2823"
                     /db_xref="GeneID:10021"
                     /db_xref="HGNC:HGNC:16882"
                     /db_xref="MIM:605206"
ORIGIN      
        1 mtydlasavv rivnligmml llchwdgclq flvpmlqdfp ddcwvsinnm vnnswgkqys
       61 yalfkamshm lcigygrqap vgmsdvwltm lsmivgatcy amfighatal iqsldssrrq
      121 yqekykqveq ymsfhklppd trqrihdyye hryqgkmfde esilgelsep lreeiinfnc
      181 rklvasmplf anadpnfvts mltklrfevf qpgdyiireg tigkkmyfiq hgvvsvltkg
      241 nketkladgs yfgeiclltr grrtasvrad tycrlyslsv dnfnevleey pmmrrafetv
      301 aldrldrigk knsillhkvq hdlnsgvfny qeneiiqqiv qhdremahca hrvqaaasat
      361 ptptpviwtp liqaplqaaa attsvaialt hhprlpaaif rpppgsglgn lgagqtprhl
      421 krlqslipsa lgsaspassp sqvdtpssss fhiqqlagfs apaglspllp ssssspppga
      481 cgspsaptps agvaattiag fghfhkalgg slsssdspll tplqpgarsp qaaqpspapp
      541 gargglglpe hflppppssr spssspgqlg qppgelslgl atgplstpet pprqpeppsl
      601 vagasggasp vgftprggls ppghspgppr tfpsappras gshgslllpp assppppqvp
      661 qrrgtppltp grltqdlkli sasqpalpqd gaqtlrrasp hssgesmaaf plfpragggs
      721 ggsgssgglg ppgrpygaip gqhvtlprkt ssgslpppls lfgaratssg gppltagpqr
      781 epgarpepvr sklpsnl
//
LOCUS       XP_006720417             347 aa            linear   PRI 05-AUG-2025
DEFINITION  POTE ankyrin domain family member B2 isoform X1 [Homo sapiens].
ACCESSION   XP_006720417
VERSION     XP_006720417.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720354.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..347
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..347
                     /product="POTE ankyrin domain family member B2 isoform X1"
                     /calculated_mol_wt=38904
     Region          100..331
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          137..166
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          168..199
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(201,203,207..208,211..213,215..216,220,223,232,234,
                     236,240..241,244..246,248..249,253,256,265,267,269,
                     273..274,277..279,281..282,286,289,298)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          201..232
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          234..265
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          267..298
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     CDS             1..347
                     /gene="POTEB2"
                     /gene_synonym="POTE-15; POTEB"
                     /coded_by="XM_006720354.4:34..1077"
                     /db_xref="GeneID:100287399"
                     /db_xref="HGNC:HGNC:48327"
ORIGIN      
        1 mvaevcsmpa asavkkpfdl rskmgkwchh rfpccrgsgt snvgtsgdhd dsfmktlrsk
       61 mgkwcchcfp ccrgsgksnv gtwgdyddsa fmepryhvrr edldklhraa wwgkvprkdl
      121 ivmlrdtdmn krdkqkrtal hlasangnse vvqllldrrc qlnvldnkkr talikavqcq
      181 edecvlmlle hgadgniqde ygntalhyai ynedklmaka lllygadies knkcgltpll
      241 lgvheqkqev vkflikkkan lnaldrygrt alilavccgs asivnllleq nvdvssqdls
      301 gqtareyavs shhhvicell sdykekqmlk issensnpen vsrtrnk
//
LOCUS       XP_011542095             339 aa            linear   PRI 05-AUG-2025
DEFINITION  POTE ankyrin domain family member B2 isoform X2 [Homo sapiens].
ACCESSION   XP_011542095
VERSION     XP_011542095.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011543793.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..339
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..339
                     /product="POTE ankyrin domain family member B2 isoform X2"
                     /calculated_mol_wt=37918
     Region          100..331
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          137..166
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          168..199
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(201,203,207..208,211..213,215..216,220,223,232,234,
                     236,240..241,244..246,248..249,253,256,265,267,269,
                     273..274,277..279,281..282,286,289,298)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          201..232
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          234..265
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          267..298
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     CDS             1..339
                     /gene="POTEB2"
                     /gene_synonym="POTE-15; POTEB"
                     /coded_by="XM_011543793.3:34..1053"
                     /db_xref="GeneID:100287399"
                     /db_xref="HGNC:HGNC:48327"
ORIGIN      
        1 mvaevcsmpa asavkkpfdl rskmgkwchh rfpccrgsgt snvgtsgdhd dsfmktlrsk
       61 mgkwcchcfp ccrgsgksnv gtwgdyddsa fmepryhvrr edldklhraa wwgkvprkdl
      121 ivmlrdtdmn krdkqkrtal hlasangnse vvqllldrrc qlnvldnkkr talikavqcq
      181 edecvlmlle hgadgniqde ygntalhyai ynedklmaka lllygadies knkcgltpll
      241 lgvheqkqev vkflikkkan lnaldrygrt alilavccgs asivnllleq nvdvssqdls
      301 gqtareyavs shhhvicell sdykekqmlk issensnpv
//
LOCUS       XP_016877342             339 aa            linear   PRI 05-AUG-2025
DEFINITION  POTE ankyrin domain family member B2 isoform X3 [Homo sapiens].
ACCESSION   XP_016877342
VERSION     XP_016877342.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021853.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..339
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..339
                     /product="POTE ankyrin domain family member B2 isoform X3"
                     /calculated_mol_wt=37876
     Region          100..331
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          137..166
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          168..199
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(201,203,207..208,211..213,215..216,220,223,232,234,
                     236,240..241,244..246,248..249,253,256,265,267,269,
                     273..274,277..279,281..282,286,289,298)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          201..232
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          234..265
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          267..298
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     CDS             1..339
                     /gene="POTEB2"
                     /gene_synonym="POTE-15; POTEB"
                     /coded_by="XM_017021853.2:34..1053"
                     /db_xref="GeneID:100287399"
                     /db_xref="HGNC:HGNC:48327"
ORIGIN      
        1 mvaevcsmpa asavkkpfdl rskmgkwchh rfpccrgsgt snvgtsgdhd dsfmktlrsk
       61 mgkwcchcfp ccrgsgksnv gtwgdyddsa fmepryhvrr edldklhraa wwgkvprkdl
      121 ivmlrdtdmn krdkqkrtal hlasangnse vvqllldrrc qlnvldnkkr talikavqcq
      181 edecvlmlle hgadgniqde ygntalhyai ynedklmaka lllygadies knkcgltpll
      241 lgvheqkqev vkflikkkan lnaldrygrt alilavccgs asivnllleq nvdvssqdls
      301 gqtareyavs shhhvicell sdykekqmlk issensnpg
//
LOCUS       XP_011519451             153 aa            linear   PRI 05-AUG-2025
DEFINITION  putative transmembrane protein INAFM2 isoform X1 [Homo sapiens].
ACCESSION   XP_011519451
VERSION     XP_011519451.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521149.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..153
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..153
                     /product="putative transmembrane protein INAFM2 isoform
                     X1"
                     /calculated_mol_wt=15308
     Region          31..63
                     /region_name="InaF-motif"
                     /note="TRP-interacting helix; pfam15018"
                     /db_xref="CDD:464449"
     CDS             1..153
                     /gene="INAFM2"
                     /gene_synonym="LINC00984; OGU1"
                     /coded_by="XM_011521149.4:365..826"
                     /db_xref="GeneID:100505573"
                     /db_xref="HGNC:HGNC:35165"
ORIGIN      
        1 mkerdaapae rgkpatytgd kkakmaaktn kkwvrlatvf ayvlsvslaa ivlavyysli
       61 wqpvgagtsg gaagpppggs natgpsgtsg aaaagpnttg ssrreaprdv pplqaarpap
      121 peppadsppa gplerprgpd edeeetaaap gsr
//
LOCUS       XP_016877346             214 aa            linear   PRI 05-AUG-2025
DEFINITION  tetraspanin-3 isoform X1 [Homo sapiens].
ACCESSION   XP_016877346
VERSION     XP_016877346.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021857.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..214
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..214
                     /product="tetraspanin-3 isoform X1"
                     /calculated_mol_wt=23756
     Region          <23..196
                     /region_name="Tetraspanin"
                     /note="Tetraspanin family; pfam00335"
                     /db_xref="CDD:459767"
     Region          65..171
                     /region_name="TM4SF8_like_LEL"
                     /note="Tetraspanin, extracellular domain or large
                     extracellular loop (LEL), TM4SF8_like subfamily.
                     Tetraspanins are trans-membrane proteins with 4
                     trans-membrane segments. Both the N- and C-termini lie on
                     the intracellular side of the membrane. This alignment...;
                     cd03163"
                     /db_xref="CDD:239416"
     Site            order(67,72,76,78..79,82,98,101..102,105..106)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:239416"
     CDS             1..214
                     /gene="TSPAN3"
                     /gene_synonym="TM4-A; TM4SF8; TSPAN-3"
                     /coded_by="XM_017021857.2:1..645"
                     /db_xref="GeneID:10099"
                     /db_xref="HGNC:HGNC:17752"
                     /db_xref="MIM:613134"
ORIGIN      
        1 mwepmssslm mtmttslkmc trallfiigl igccatires rcglatfvii lllvfvtevv
       61 vvvlgyvyra kvenevdrsi qkvyktyngt npdaasraid yvqrqlhccg ihnysdwent
      121 dwfketknqs vplsccreta sncngslahp sdlyaegcea lvvkklqeim mhviwaalaf
      181 aaiqllgmlc acivlcrrsr dpayellitg gtya
//
LOCUS       XP_047288028             347 aa            linear   PRI 05-AUG-2025
DEFINITION  POTE ankyrin domain family member B isoform X1 [Homo sapiens].
ACCESSION   XP_047288028
VERSION     XP_047288028.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432072.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 32% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..347
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..347
                     /product="POTE ankyrin domain family member B isoform X1"
                     /calculated_mol_wt=38904
     Region          100..331
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          137..166
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          168..199
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(201,203,207..208,211..213,215..216,220,223,232,234,
                     236,240..241,244..246,248..249,253,256,265,267,269,
                     273..274,277..279,281..282,286,289,298)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          201..232
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          234..265
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          267..298
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     CDS             1..347
                     /gene="POTEB"
                     /gene_synonym="A26B1; CT104.5; POTE-15; POTE15; POTEB2"
                     /coded_by="XM_047432072.1:490..1533"
                     /db_xref="GeneID:100996331"
                     /db_xref="HGNC:HGNC:33734"
                     /db_xref="MIM:608912"
ORIGIN      
        1 mvaevcsmpa asavkkpfdl rskmgkwchh rfpccrgsgt snvgtsgdhd dsfmktlrsk
       61 mgkwcchcfp ccrgsgksnv gtwgdyddsa fmepryhvrr edldklhraa wwgkvprkdl
      121 ivmlrdtdmn krdkqkrtal hlasangnse vvqllldrrc qlnvldnkkr talikavqcq
      181 edecvlmlle hgadgniqde ygntalhyai ynedklmaka lllygadies knkcgltpll
      241 lgvheqkqev vkflikkkan lnaldrygrt alilavccgs asivnllleq nvdvssqdls
      301 gqtareyavs shhhvicell sdykekqmlk issensnpen vsrtrnk
//
LOCUS       XP_011542096             339 aa            linear   PRI 05-AUG-2025
DEFINITION  POTE ankyrin domain family member B isoform X2 [Homo sapiens].
ACCESSION   XP_011542096
VERSION     XP_011542096.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011543794.3
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 32% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..339
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..339
                     /product="POTE ankyrin domain family member B isoform X2"
                     /calculated_mol_wt=37918
     Region          100..331
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          137..166
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          168..199
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(201,203,207..208,211..213,215..216,220,223,232,234,
                     236,240..241,244..246,248..249,253,256,265,267,269,
                     273..274,277..279,281..282,286,289,298)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          201..232
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          234..265
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          267..298
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     CDS             1..339
                     /gene="POTEB"
                     /gene_synonym="A26B1; CT104.5; POTE-15; POTE15; POTEB2"
                     /coded_by="XM_011543794.3:490..1509"
                     /db_xref="GeneID:100996331"
                     /db_xref="HGNC:HGNC:33734"
                     /db_xref="MIM:608912"
ORIGIN      
        1 mvaevcsmpa asavkkpfdl rskmgkwchh rfpccrgsgt snvgtsgdhd dsfmktlrsk
       61 mgkwcchcfp ccrgsgksnv gtwgdyddsa fmepryhvrr edldklhraa wwgkvprkdl
      121 ivmlrdtdmn krdkqkrtal hlasangnse vvqllldrrc qlnvldnkkr talikavqcq
      181 edecvlmlle hgadgniqde ygntalhyai ynedklmaka lllygadies knkcgltpll
      241 lgvheqkqev vkflikkkan lnaldrygrt alilavccgs asivnllleq nvdvssqdls
      301 gqtareyavs shhhvicell sdykekqmlk issensnpv
//
LOCUS       XP_016877347             339 aa            linear   PRI 05-AUG-2025
DEFINITION  POTE ankyrin domain family member B isoform X3 [Homo sapiens].
ACCESSION   XP_016877347
VERSION     XP_016877347.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021858.2
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 32% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..339
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..339
                     /product="POTE ankyrin domain family member B isoform X3"
                     /calculated_mol_wt=37876
     Region          100..331
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          137..166
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          168..199
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(201,203,207..208,211..213,215..216,220,223,232,234,
                     236,240..241,244..246,248..249,253,256,265,267,269,
                     273..274,277..279,281..282,286,289,298)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          201..232
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          234..265
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          267..298
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     CDS             1..339
                     /gene="POTEB"
                     /gene_synonym="A26B1; CT104.5; POTE-15; POTE15; POTEB2"
                     /coded_by="XM_017021858.2:490..1509"
                     /db_xref="GeneID:100996331"
                     /db_xref="HGNC:HGNC:33734"
                     /db_xref="MIM:608912"
ORIGIN      
        1 mvaevcsmpa asavkkpfdl rskmgkwchh rfpccrgsgt snvgtsgdhd dsfmktlrsk
       61 mgkwcchcfp ccrgsgksnv gtwgdyddsa fmepryhvrr edldklhraa wwgkvprkdl
      121 ivmlrdtdmn krdkqkrtal hlasangnse vvqllldrrc qlnvldnkkr talikavqcq
      181 edecvlmlle hgadgniqde ygntalhyai ynedklmaka lllygadies knkcgltpll
      241 lgvheqkqev vkflikkkan lnaldrygrt alilavccgs asivnllleq nvdvssqdls
      301 gqtareyavs shhhvicell sdykekqmlk issensnpg
//
LOCUS       XP_047288029             826 aa            linear   PRI 05-AUG-2025
DEFINITION  RAS guanyl-releasing protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047288029
VERSION     XP_047288029.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432073.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..826
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..826
                     /product="RAS guanyl-releasing protein 1 isoform X1"
                     /calculated_mol_wt=93392
     Region          83..204
                     /region_name="RasGEFN"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     GTPases; N-terminal motif; smart00229"
                     /db_xref="CDD:214571"
     Site            order(101,152..153,156,159..160,195..196,199,206)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:100121"
     Region          230..466
                     /region_name="RasGEF"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     small GTPases; smart00147"
                     /db_xref="CDD:214539"
     Site            order(263..265,273..274,276..278,280..281,284..285,288,
                     321,324..325,327..329,331..334,336..337,357,360,365..367,
                     370,383..385,388..390,392..394,396..399,414,418,453,
                     456..457)
                     /site_type="other"
                     /note="Ras interaction site [polypeptide binding]"
                     /db_xref="CDD:238087"
     Region          <500..556
                     /region_name="FRQ1"
                     /note="Ca2+-binding protein, EF-hand superfamily [Signal
                     transduction mechanisms]; COG5126"
                     /db_xref="CDD:444056"
     Region          569..623
                     /region_name="C1_RASGRP1"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in RAS guanyl-releasing protein 1 (RASGRP1) and
                     similar proteins; cd20860"
                     /db_xref="CDD:410410"
     Site            order(576..582,590..594,597)
                     /site_type="other"
                     /note="putative DAG/PE binding site [chemical binding]"
                     /db_xref="CDD:410410"
     Region          768..822
                     /region_name="cc_RasGRP1_C"
                     /note="C-terminal coiled-coil domain of RAS
                     guanyl-releasing protein 1 (RasGRP1) and similar proteins;
                     cd22290"
                     /db_xref="CDD:412086"
     Site            order(774..777,780,783..784,787..788,790..791,794..795,
                     797..798,801,805,808..809,811)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:412086"
     CDS             1..826
                     /gene="RASGRP1"
                     /gene_synonym="CALDAG-GEFI; CALDAG-GEFII; IMD64; RASGRP"
                     /coded_by="XM_047432073.1:487..2967"
                     /db_xref="GeneID:10125"
                     /db_xref="HGNC:HGNC:9878"
                     /db_xref="MIM:603962"
ORIGIN      
        1 masispapei nclisipfls nlpsergaar lsphcllsfp rkpshgcraa skarleakpa
       61 nspfpshpsl ahitqfrmmv slghlakgas lddlidsciq sfdadgnlcr snqllqvmlt
      121 mhrivissae llqkvitlyk dalaknspgl clkicyfvry witefwvmfk mdasltdtme
      181 efqelvkakg eelhcrlidt tqinardwsr kltqriksnt skkrkvsllf dhlepeelse
      241 hltylefksf rrisfsdyqn ylvnscvken ptmersialc ngisqwvqlm vlsrptpqlr
      301 aevfikfiqv aqklhqlqnf ntlmaviggl chssisrlke tsshvphein kvlgemtell
      361 sssrnydnyr raygectdfk ipilgvhlkd lislyeampd yledgkvnvh kllalynhis
      421 elvqlqevap pleankdlvh lltlsldlyy tedeiyelsy areprnhrap pltpskppvv
      481 vdwasgvspk pdpktiskhv qrmvdsvfkn ydhdqdgyis qeefekiaas fpfsfcvmdk
      541 dreglisrde itayfmrass iysklglgfp hnfqettylk ptfcdncagf lwgvikqgyr
      601 ckdcgmnchk qckdlvvfec kkraknpvap tenntsvgpv snlcslgakd llhapeegpf
      661 tfpngeaveh geeskdrtim lmgvssqkis lrlkravahk atqtesqpwi gsegpsgpfv
      721 lssprktaqd tlyvlpspts pcpspvlvrk rafvkwenkd slikskeelr hlrlptyqel
      781 eqeintlkad ndalkiqlky aqkkieslql eksnhvlaqm eqgdcs
//
LOCUS       XP_047288030             791 aa            linear   PRI 05-AUG-2025
DEFINITION  RAS guanyl-releasing protein 1 isoform X2 [Homo sapiens].
ACCESSION   XP_047288030
VERSION     XP_047288030.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432074.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..791
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..791
                     /product="RAS guanyl-releasing protein 1 isoform X2"
                     /calculated_mol_wt=89615
     Region          83..204
                     /region_name="RasGEFN"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     GTPases; N-terminal motif; smart00229"
                     /db_xref="CDD:214571"
     Site            order(101,152..153,156,159..160,195..196,199,206)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:100121"
     Region          230..466
                     /region_name="RasGEF"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     small GTPases; smart00147"
                     /db_xref="CDD:214539"
     Site            order(263..265,273..274,276..278,280..281,284..285,288,
                     321,324..325,327..329,331..334,336..337,357,360,365..367,
                     370,383..385,388..390,392..394,396..399,414,418,453,
                     456..457)
                     /site_type="other"
                     /note="Ras interaction site [polypeptide binding]"
                     /db_xref="CDD:238087"
     Region          472..521
                     /region_name="EF-hand_7"
                     /note="EF-hand domain pair; pfam13499"
                     /db_xref="CDD:463900"
     Region          534..588
                     /region_name="C1_RASGRP1"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in RAS guanyl-releasing protein 1 (RASGRP1) and
                     similar proteins; cd20860"
                     /db_xref="CDD:410410"
     Site            order(541..547,555..559,562)
                     /site_type="other"
                     /note="putative DAG/PE binding site [chemical binding]"
                     /db_xref="CDD:410410"
     Region          733..787
                     /region_name="cc_RasGRP1_C"
                     /note="C-terminal coiled-coil domain of RAS
                     guanyl-releasing protein 1 (RasGRP1) and similar proteins;
                     cd22290"
                     /db_xref="CDD:412086"
     Site            order(739..742,745,748..749,752..753,755..756,759..760,
                     762..763,766,770,773..774,776)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:412086"
     CDS             1..791
                     /gene="RASGRP1"
                     /gene_synonym="CALDAG-GEFI; CALDAG-GEFII; IMD64; RASGRP"
                     /coded_by="XM_047432074.1:487..2862"
                     /db_xref="GeneID:10125"
                     /db_xref="HGNC:HGNC:9878"
                     /db_xref="MIM:603962"
ORIGIN      
        1 masispapei nclisipfls nlpsergaar lsphcllsfp rkpshgcraa skarleakpa
       61 nspfpshpsl ahitqfrmmv slghlakgas lddlidsciq sfdadgnlcr snqllqvmlt
      121 mhrivissae llqkvitlyk dalaknspgl clkicyfvry witefwvmfk mdasltdtme
      181 efqelvkakg eelhcrlidt tqinardwsr kltqriksnt skkrkvsllf dhlepeelse
      241 hltylefksf rrisfsdyqn ylvnscvken ptmersialc ngisqwvqlm vlsrptpqlr
      301 aevfikfiqv aqklhqlqnf ntlmaviggl chssisrlke tsshvphein kvlgemtell
      361 sssrnydnyr raygectdfk ipilgvhlkd lislyeampd yledgkvnvh kllalynhis
      421 elvqlqevap pleankdlvh lltlsldlyy tedeiyelsy areprnhrap svfknydhdq
      481 dgyisqeefe kiaasfpfsf cvmdkdregl isrdeitayf mrassiyskl glgfphnfqe
      541 ttylkptfcd ncagflwgvi kqgyrckdcg mnchkqckdl vvfeckkrak npvaptennt
      601 svgpvsnlcs lgakdllhap eegpftfpng eavehgeesk drtimlmgvs sqkislrlkr
      661 avahkatqte sqpwigsegp sgpfvlsspr ktaqdtlyvl psptspcpsp vlvrkrafvk
      721 wenkdsliks keelrhlrlp tyqeleqein tlkadndalk iqlkyaqkki eslqleksnh
      781 vlaqmeqgdc s
//
LOCUS       XP_047288031             775 aa            linear   PRI 05-AUG-2025
DEFINITION  RAS guanyl-releasing protein 1 isoform X3 [Homo sapiens].
ACCESSION   XP_047288031
VERSION     XP_047288031.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432075.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..775
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..775
                     /product="RAS guanyl-releasing protein 1 isoform X3"
                     /calculated_mol_wt=87895
     Region          83..204
                     /region_name="RasGEFN"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     GTPases; N-terminal motif; smart00229"
                     /db_xref="CDD:214571"
     Site            order(101,152..153,156,159..160,195..196,199,206)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:100121"
     Region          230..466
                     /region_name="RasGEF"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     small GTPases; smart00147"
                     /db_xref="CDD:214539"
     Site            order(263..265,273..274,276..278,280..281,284..285,288,
                     321,324..325,327..329,331..334,336..337,357,360,365..367,
                     370,383..385,388..390,392..394,396..399,414,418,453,
                     456..457)
                     /site_type="other"
                     /note="Ras interaction site [polypeptide binding]"
                     /db_xref="CDD:238087"
     Region          <500..556
                     /region_name="FRQ1"
                     /note="Ca2+-binding protein, EF-hand superfamily [Signal
                     transduction mechanisms]; COG5126"
                     /db_xref="CDD:444056"
     Region          569..>602
                     /region_name="C1"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     superfamily; cl00040"
                     /db_xref="CDD:412127"
     Region          717..771
                     /region_name="cc_RasGRP1_C"
                     /note="C-terminal coiled-coil domain of RAS
                     guanyl-releasing protein 1 (RasGRP1) and similar proteins;
                     cd22290"
                     /db_xref="CDD:412086"
     Site            order(723..726,729,732..733,736..737,739..740,743..744,
                     746..747,750,754,757..758,760)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:412086"
     CDS             1..775
                     /gene="RASGRP1"
                     /gene_synonym="CALDAG-GEFI; CALDAG-GEFII; IMD64; RASGRP"
                     /coded_by="XM_047432075.1:487..2814"
                     /db_xref="GeneID:10125"
                     /db_xref="HGNC:HGNC:9878"
                     /db_xref="MIM:603962"
ORIGIN      
        1 masispapei nclisipfls nlpsergaar lsphcllsfp rkpshgcraa skarleakpa
       61 nspfpshpsl ahitqfrmmv slghlakgas lddlidsciq sfdadgnlcr snqllqvmlt
      121 mhrivissae llqkvitlyk dalaknspgl clkicyfvry witefwvmfk mdasltdtme
      181 efqelvkakg eelhcrlidt tqinardwsr kltqriksnt skkrkvsllf dhlepeelse
      241 hltylefksf rrisfsdyqn ylvnscvken ptmersialc ngisqwvqlm vlsrptpqlr
      301 aevfikfiqv aqklhqlqnf ntlmaviggl chssisrlke tsshvphein kvlgemtell
      361 sssrnydnyr raygectdfk ipilgvhlkd lislyeampd yledgkvnvh kllalynhis
      421 elvqlqevap pleankdlvh lltlsldlyy tedeiyelsy areprnhrap pltpskppvv
      481 vdwasgvspk pdpktiskhv qrmvdsvfkn ydhdqdgyis qeefekiaas fpfsfcvmdk
      541 dreglisrde itayfmrass iysklglgfp hnfqettylk ptfcdncagf lwgvikqgyr
      601 ckapeegpft fpngeavehg eeskdrtiml mgvssqkisl rlkravahka tqtesqpwig
      661 segpsgpfvl ssprktaqdt lyvlpsptsp cpspvlvrkr afvkwenkds likskeelrh
      721 lrlptyqele qeintlkadn dalkiqlkya qkkieslqle ksnhvlaqme qgdcs
//
LOCUS       XP_047288032             661 aa            linear   PRI 05-AUG-2025
DEFINITION  RAS guanyl-releasing protein 1 isoform X4 [Homo sapiens].
ACCESSION   XP_047288032
VERSION     XP_047288032.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432076.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..661
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..661
                     /product="RAS guanyl-releasing protein 1 isoform X4"
                     /calculated_mol_wt=74937
     Region          83..204
                     /region_name="RasGEFN"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     GTPases; N-terminal motif; smart00229"
                     /db_xref="CDD:214571"
     Site            order(101,152..153,156,159..160,195..196,199,206)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:100121"
     Region          230..466
                     /region_name="RasGEF"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     small GTPases; smart00147"
                     /db_xref="CDD:214539"
     Site            order(263..265,273..274,276..278,280..281,284..285,288,
                     321,324..325,327..329,331..334,336..337,357,360,365..367,
                     370,383..385,388..390,392..394,396..399,414,418,453,
                     456..457)
                     /site_type="other"
                     /note="Ras interaction site [polypeptide binding]"
                     /db_xref="CDD:238087"
     Region          <500..556
                     /region_name="FRQ1"
                     /note="Ca2+-binding protein, EF-hand superfamily [Signal
                     transduction mechanisms]; COG5126"
                     /db_xref="CDD:444056"
     Region          569..623
                     /region_name="C1_RASGRP1"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in RAS guanyl-releasing protein 1 (RASGRP1) and
                     similar proteins; cd20860"
                     /db_xref="CDD:410410"
     Site            order(576..582,590..594,597)
                     /site_type="other"
                     /note="putative DAG/PE binding site [chemical binding]"
                     /db_xref="CDD:410410"
     CDS             1..661
                     /gene="RASGRP1"
                     /gene_synonym="CALDAG-GEFI; CALDAG-GEFII; IMD64; RASGRP"
                     /coded_by="XM_047432076.1:487..2472"
                     /db_xref="GeneID:10125"
                     /db_xref="HGNC:HGNC:9878"
                     /db_xref="MIM:603962"
ORIGIN      
        1 masispapei nclisipfls nlpsergaar lsphcllsfp rkpshgcraa skarleakpa
       61 nspfpshpsl ahitqfrmmv slghlakgas lddlidsciq sfdadgnlcr snqllqvmlt
      121 mhrivissae llqkvitlyk dalaknspgl clkicyfvry witefwvmfk mdasltdtme
      181 efqelvkakg eelhcrlidt tqinardwsr kltqriksnt skkrkvsllf dhlepeelse
      241 hltylefksf rrisfsdyqn ylvnscvken ptmersialc ngisqwvqlm vlsrptpqlr
      301 aevfikfiqv aqklhqlqnf ntlmaviggl chssisrlke tsshvphein kvlgemtell
      361 sssrnydnyr raygectdfk ipilgvhlkd lislyeampd yledgkvnvh kllalynhis
      421 elvqlqevap pleankdlvh lltlsldlyy tedeiyelsy areprnhrap pltpskppvv
      481 vdwasgvspk pdpktiskhv qrmvdsvfkn ydhdqdgyis qeefekiaas fpfsfcvmdk
      541 dreglisrde itayfmrass iysklglgfp hnfqettylk ptfcdncagf lwgvikqgyr
      601 ckdcgmnchk qckdlvvfec kkraknpvap tenntsvgpv snlcslgakd llhgnkyses
      661 r
//
LOCUS       XP_047288033             545 aa            linear   PRI 05-AUG-2025
DEFINITION  RAS guanyl-releasing protein 1 isoform X5 [Homo sapiens].
ACCESSION   XP_047288033
VERSION     XP_047288033.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432077.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..545
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..545
                     /product="RAS guanyl-releasing protein 1 isoform X5"
                     /calculated_mol_wt=61866
     Region          83..204
                     /region_name="RasGEFN"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     GTPases; N-terminal motif; smart00229"
                     /db_xref="CDD:214571"
     Site            order(101,152..153,156,159..160,195..196,199,206)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:100121"
     Region          230..466
                     /region_name="RasGEF"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     small GTPases; smart00147"
                     /db_xref="CDD:214539"
     Site            order(263..265,273..274,276..278,280..281,284..285,288,
                     321,324..325,327..329,331..334,336..337,357,360,365..367,
                     370,383..385,388..390,392..394,396..399,414,418,453,
                     456..457)
                     /site_type="other"
                     /note="Ras interaction site [polypeptide binding]"
                     /db_xref="CDD:238087"
     Region          504..531
                     /region_name="EF-hand_1"
                     /note="EF hand; pfam00036"
                     /db_xref="CDD:425435"
     CDS             1..545
                     /gene="RASGRP1"
                     /gene_synonym="CALDAG-GEFI; CALDAG-GEFII; IMD64; RASGRP"
                     /coded_by="XM_047432077.1:487..2124"
                     /db_xref="GeneID:10125"
                     /db_xref="HGNC:HGNC:9878"
                     /db_xref="MIM:603962"
ORIGIN      
        1 masispapei nclisipfls nlpsergaar lsphcllsfp rkpshgcraa skarleakpa
       61 nspfpshpsl ahitqfrmmv slghlakgas lddlidsciq sfdadgnlcr snqllqvmlt
      121 mhrivissae llqkvitlyk dalaknspgl clkicyfvry witefwvmfk mdasltdtme
      181 efqelvkakg eelhcrlidt tqinardwsr kltqriksnt skkrkvsllf dhlepeelse
      241 hltylefksf rrisfsdyqn ylvnscvken ptmersialc ngisqwvqlm vlsrptpqlr
      301 aevfikfiqv aqklhqlqnf ntlmaviggl chssisrlke tsshvphein kvlgemtell
      361 sssrnydnyr raygectdfk ipilgvhlkd lislyeampd yledgkvnvh kllalynhis
      421 elvqlqevap pleankdlvh lltlsldlyy tedeiyelsy areprnhrap pltpskppvv
      481 vdwasgvspk pdpktiskhv qrmvdsvfkn ydhdqdgyis qeefekiaas fpfsfcvmdk
      541 dssge
//
LOCUS       XP_047288034             545 aa            linear   PRI 05-AUG-2025
DEFINITION  RAS guanyl-releasing protein 1 isoform X5 [Homo sapiens].
ACCESSION   XP_047288034
VERSION     XP_047288034.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432078.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..545
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..545
                     /product="RAS guanyl-releasing protein 1 isoform X5"
                     /calculated_mol_wt=61866
     Region          83..204
                     /region_name="RasGEFN"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     GTPases; N-terminal motif; smart00229"
                     /db_xref="CDD:214571"
     Site            order(101,152..153,156,159..160,195..196,199,206)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:100121"
     Region          230..466
                     /region_name="RasGEF"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     small GTPases; smart00147"
                     /db_xref="CDD:214539"
     Site            order(263..265,273..274,276..278,280..281,284..285,288,
                     321,324..325,327..329,331..334,336..337,357,360,365..367,
                     370,383..385,388..390,392..394,396..399,414,418,453,
                     456..457)
                     /site_type="other"
                     /note="Ras interaction site [polypeptide binding]"
                     /db_xref="CDD:238087"
     Region          504..531
                     /region_name="EF-hand_1"
                     /note="EF hand; pfam00036"
                     /db_xref="CDD:425435"
     CDS             1..545
                     /gene="RASGRP1"
                     /gene_synonym="CALDAG-GEFI; CALDAG-GEFII; IMD64; RASGRP"
                     /coded_by="XM_047432078.1:487..2124"
                     /db_xref="GeneID:10125"
                     /db_xref="HGNC:HGNC:9878"
                     /db_xref="MIM:603962"
ORIGIN      
        1 masispapei nclisipfls nlpsergaar lsphcllsfp rkpshgcraa skarleakpa
       61 nspfpshpsl ahitqfrmmv slghlakgas lddlidsciq sfdadgnlcr snqllqvmlt
      121 mhrivissae llqkvitlyk dalaknspgl clkicyfvry witefwvmfk mdasltdtme
      181 efqelvkakg eelhcrlidt tqinardwsr kltqriksnt skkrkvsllf dhlepeelse
      241 hltylefksf rrisfsdyqn ylvnscvken ptmersialc ngisqwvqlm vlsrptpqlr
      301 aevfikfiqv aqklhqlqnf ntlmaviggl chssisrlke tsshvphein kvlgemtell
      361 sssrnydnyr raygectdfk ipilgvhlkd lislyeampd yledgkvnvh kllalynhis
      421 elvqlqevap pleankdlvh lltlsldlyy tedeiyelsy areprnhrap pltpskppvv
      481 vdwasgvspk pdpktiskhv qrmvdsvfkn ydhdqdgyis qeefekiaas fpfsfcvmdk
      541 dssge
//
LOCUS       XP_047288035              54 aa            linear   PRI 05-AUG-2025
DEFINITION  protein PIGBOS1 isoform X1 [Homo sapiens].
ACCESSION   XP_047288035
VERSION     XP_047288035.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432079.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..54
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..54
                     /product="protein PIGBOS1 isoform X1"
                     /calculated_mol_wt=6182
     CDS             1..54
                     /gene="PIGBOS1"
                     /gene_synonym="HP06981"
                     /coded_by="XM_047432079.1:372..536"
                     /db_xref="GeneID:101928527"
                     /db_xref="HGNC:HGNC:50696"
                     /db_xref="MIM:618809"
ORIGIN      
        1 mfrrltfaql lfatvlgiag gvyifqpvfe qyakdqkelk ekmqlvqese ekks
//
LOCUS       XP_047288042            1916 aa            linear   PRI 05-AUG-2025
DEFINITION  C-myc promoter-binding protein isoform X1 [Homo sapiens].
ACCESSION   XP_047288042
VERSION     XP_047288042.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432086.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1916
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1916
                     /product="C-myc promoter-binding protein isoform X1"
                     /calculated_mol_wt=214707
     Region          194..276
                     /region_name="uDENN"
                     /note="Domain always found upstream of DENN domain, found
                     in a variety of signalling proteins; smart00800"
                     /db_xref="CDD:214824"
     Region          308..492
                     /region_name="DENN"
                     /note="DENN (AEX-3) domain; pfam02141"
                     /db_xref="CDD:460461"
     Region          559..632
                     /region_name="dDENN"
                     /note="Domain always found downstream of DENN domain,
                     found in a variety of signalling proteins; smart00801"
                     /db_xref="CDD:129037"
     Region          808..848
                     /region_name="PPR_2"
                     /note="PPR repeat family; pfam13041"
                     /db_xref="CDD:463778"
     Region          810..839
                     /region_name="PPR repeat"
                     /note="PPR repeat [structural motif]"
                     /db_xref="CDD:276811"
     CDS             1..1916
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /coded_by="XM_047432086.1:386..6136"
                     /db_xref="GeneID:10260"
                     /db_xref="HGNC:HGNC:24321"
                     /db_xref="MIM:600382"
ORIGIN      
        1 miedkgprva dyfvvagltd vskpleeeih fndachkvak pkepitdvsv iikslgeevp
       61 qdyicidvtp tglsadlnng slvgpqiylc yrrgrdkppl tdlgvlydwk erlkqgceii
      121 qstpygrpan isgstssqri yityrrasen mtqntlavtd iciiipskge spphtfckvd
      181 knlnnsmwgs avylcykksv aktntvsyka glicrypqed yesfslpesv plfclpmgat
      241 iecwpsnsky plpvfstfvl tgasaekvyg aaiqfyepys eenltekqrl llgltsadgk
      301 sdssktihtn kcicllshwp ffdafrkflt flyrysisgp hvlpiekhis hfmhkvpfps
      361 pqrprilvql sphdnlilsq pvssplplsg gkfstllqnl gpenavtllv favtehkili
      421 hslrpsvlts vtealvsmif pfhwpcpyvp lcplaladvl sapcpfivgi dsryfdlydp
      481 ppdvscvdvd tntisqigdk knvawkilpk kpcknlmntl nnlhqqlakl qqrprddglm
      541 dlaindydfn sgkrlhmidl eiqeaflffm asilkgyrsy lrpitqapse tatdaaslfa
      601 lqaflrsrdr shqkfynmmt ktqmfirfie ecsfvsdkda slaffddcvd kvdmdksgev
      661 rlieldesfk sehtvfvtpp eiphlpngee pplqysyngf pvlrnnlfer pegflqakkn
      721 klpskssspn splpmfrrtk qeiksahkia kryssipqmw srcllrhcyg lwficlpayv
      781 kvchskvral ktaydvlkkm qskkmdppde vcyrilmqlc gqydqpvlav rvlfemqkag
      841 idpnaitygy ynkavlestw psrsrsgyfl wtkvrnvvlg vtqfkralkk hahlsqttls
      901 adgsdldavs hgsmdsghgt htveqapfnt glikvyatdd rsstggqsdl gynslskdev
      961 rrgdtstedi qeekdkkgsd csslsesest kgsadclpkl syqnsssivr ltgtsnnsag
     1021 kisgesmest pelllissle dtnetrniqs rcfrkrhksd netnlqqqvv wgnrnrnlsg
     1081 gvlmgfmlnr inqeatpgdi veklgadaki lsnviskstr pntldigkpp lrskrdslek
     1141 essdddtpfd gsnyladkvd spvifdledl dsetdvskag cvatqnpkri qrmnssfsvk
     1201 pfektdvatg fdplsllvae teqqqkeeee ededdsksis tpsarrdlae eivmymnnms
     1261 spltsrtpsi dlqracddkl nkkspplvka crrsslppns pkpvrltksk sytkseekpr
     1321 drlwsspafs ptcpfreesq dtlthsspsf nldtllvpkl dvlrnsmfta gkgvaekask
     1381 wysrftmytt sskdqssdrt slssvgaqds estsltdedv chelegpiss qetsatsgtk
     1441 ridlsrisle ssaslegsls kfalpgksev tssfnasntn ifqnyamevl isscsrcrtc
     1501 dclvhdeeim agwtaddsnl nttcpfcgni flpflnieir dlrrpgryfl ksspstenmh
     1561 fpssissqtr qscistsasg ldtsalsvqg nfdlnskskl qenfctrsiq ipanrsktam
     1621 skcpifpmar sistsgpldk edtgrqklis tgslpatlqg atdslglewh lpspdpvtvp
     1681 ylsplvvwke lesllenegd haitvadfvd hhpivfwnlv wyfrrldlps nlpglilsse
     1741 hcnkyskipr hcmsedskyv liqmlwdnmk lhqdpgqply ilwnahsqsr tllfetqkyp
     1801 mvhllqksdn sfnqellksm vksikmndvy gpmsqiletl nkcphfkrqr slyreilfls
     1861 lvalgrenid idafdkeykm aydrltpsqv ksthncdrpp stgvmecrkt fgepyl
//
LOCUS       XP_047288043            1916 aa            linear   PRI 05-AUG-2025
DEFINITION  C-myc promoter-binding protein isoform X1 [Homo sapiens].
ACCESSION   XP_047288043
VERSION     XP_047288043.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432087.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1916
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1916
                     /product="C-myc promoter-binding protein isoform X1"
                     /calculated_mol_wt=214707
     Region          194..276
                     /region_name="uDENN"
                     /note="Domain always found upstream of DENN domain, found
                     in a variety of signalling proteins; smart00800"
                     /db_xref="CDD:214824"
     Region          308..492
                     /region_name="DENN"
                     /note="DENN (AEX-3) domain; pfam02141"
                     /db_xref="CDD:460461"
     Region          559..632
                     /region_name="dDENN"
                     /note="Domain always found downstream of DENN domain,
                     found in a variety of signalling proteins; smart00801"
                     /db_xref="CDD:129037"
     Region          808..848
                     /region_name="PPR_2"
                     /note="PPR repeat family; pfam13041"
                     /db_xref="CDD:463778"
     Region          810..839
                     /region_name="PPR repeat"
                     /note="PPR repeat [structural motif]"
                     /db_xref="CDD:276811"
     CDS             1..1916
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /coded_by="XM_047432087.1:307..6057"
                     /db_xref="GeneID:10260"
                     /db_xref="HGNC:HGNC:24321"
                     /db_xref="MIM:600382"
ORIGIN      
        1 miedkgprva dyfvvagltd vskpleeeih fndachkvak pkepitdvsv iikslgeevp
       61 qdyicidvtp tglsadlnng slvgpqiylc yrrgrdkppl tdlgvlydwk erlkqgceii
      121 qstpygrpan isgstssqri yityrrasen mtqntlavtd iciiipskge spphtfckvd
      181 knlnnsmwgs avylcykksv aktntvsyka glicrypqed yesfslpesv plfclpmgat
      241 iecwpsnsky plpvfstfvl tgasaekvyg aaiqfyepys eenltekqrl llgltsadgk
      301 sdssktihtn kcicllshwp ffdafrkflt flyrysisgp hvlpiekhis hfmhkvpfps
      361 pqrprilvql sphdnlilsq pvssplplsg gkfstllqnl gpenavtllv favtehkili
      421 hslrpsvlts vtealvsmif pfhwpcpyvp lcplaladvl sapcpfivgi dsryfdlydp
      481 ppdvscvdvd tntisqigdk knvawkilpk kpcknlmntl nnlhqqlakl qqrprddglm
      541 dlaindydfn sgkrlhmidl eiqeaflffm asilkgyrsy lrpitqapse tatdaaslfa
      601 lqaflrsrdr shqkfynmmt ktqmfirfie ecsfvsdkda slaffddcvd kvdmdksgev
      661 rlieldesfk sehtvfvtpp eiphlpngee pplqysyngf pvlrnnlfer pegflqakkn
      721 klpskssspn splpmfrrtk qeiksahkia kryssipqmw srcllrhcyg lwficlpayv
      781 kvchskvral ktaydvlkkm qskkmdppde vcyrilmqlc gqydqpvlav rvlfemqkag
      841 idpnaitygy ynkavlestw psrsrsgyfl wtkvrnvvlg vtqfkralkk hahlsqttls
      901 adgsdldavs hgsmdsghgt htveqapfnt glikvyatdd rsstggqsdl gynslskdev
      961 rrgdtstedi qeekdkkgsd csslsesest kgsadclpkl syqnsssivr ltgtsnnsag
     1021 kisgesmest pelllissle dtnetrniqs rcfrkrhksd netnlqqqvv wgnrnrnlsg
     1081 gvlmgfmlnr inqeatpgdi veklgadaki lsnviskstr pntldigkpp lrskrdslek
     1141 essdddtpfd gsnyladkvd spvifdledl dsetdvskag cvatqnpkri qrmnssfsvk
     1201 pfektdvatg fdplsllvae teqqqkeeee ededdsksis tpsarrdlae eivmymnnms
     1261 spltsrtpsi dlqracddkl nkkspplvka crrsslppns pkpvrltksk sytkseekpr
     1321 drlwsspafs ptcpfreesq dtlthsspsf nldtllvpkl dvlrnsmfta gkgvaekask
     1381 wysrftmytt sskdqssdrt slssvgaqds estsltdedv chelegpiss qetsatsgtk
     1441 ridlsrisle ssaslegsls kfalpgksev tssfnasntn ifqnyamevl isscsrcrtc
     1501 dclvhdeeim agwtaddsnl nttcpfcgni flpflnieir dlrrpgryfl ksspstenmh
     1561 fpssissqtr qscistsasg ldtsalsvqg nfdlnskskl qenfctrsiq ipanrsktam
     1621 skcpifpmar sistsgpldk edtgrqklis tgslpatlqg atdslglewh lpspdpvtvp
     1681 ylsplvvwke lesllenegd haitvadfvd hhpivfwnlv wyfrrldlps nlpglilsse
     1741 hcnkyskipr hcmsedskyv liqmlwdnmk lhqdpgqply ilwnahsqsr tllfetqkyp
     1801 mvhllqksdn sfnqellksm vksikmndvy gpmsqiletl nkcphfkrqr slyreilfls
     1861 lvalgrenid idafdkeykm aydrltpsqv ksthncdrpp stgvmecrkt fgepyl
//
LOCUS       XP_047288044            1916 aa            linear   PRI 05-AUG-2025
DEFINITION  C-myc promoter-binding protein isoform X1 [Homo sapiens].
ACCESSION   XP_047288044
VERSION     XP_047288044.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432088.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1916
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1916
                     /product="C-myc promoter-binding protein isoform X1"
                     /calculated_mol_wt=214707
     Region          194..276
                     /region_name="uDENN"
                     /note="Domain always found upstream of DENN domain, found
                     in a variety of signalling proteins; smart00800"
                     /db_xref="CDD:214824"
     Region          308..492
                     /region_name="DENN"
                     /note="DENN (AEX-3) domain; pfam02141"
                     /db_xref="CDD:460461"
     Region          559..632
                     /region_name="dDENN"
                     /note="Domain always found downstream of DENN domain,
                     found in a variety of signalling proteins; smart00801"
                     /db_xref="CDD:129037"
     Region          808..848
                     /region_name="PPR_2"
                     /note="PPR repeat family; pfam13041"
                     /db_xref="CDD:463778"
     Region          810..839
                     /region_name="PPR repeat"
                     /note="PPR repeat [structural motif]"
                     /db_xref="CDD:276811"
     CDS             1..1916
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /coded_by="XM_047432088.1:255..6005"
                     /db_xref="GeneID:10260"
                     /db_xref="HGNC:HGNC:24321"
                     /db_xref="MIM:600382"
ORIGIN      
        1 miedkgprva dyfvvagltd vskpleeeih fndachkvak pkepitdvsv iikslgeevp
       61 qdyicidvtp tglsadlnng slvgpqiylc yrrgrdkppl tdlgvlydwk erlkqgceii
      121 qstpygrpan isgstssqri yityrrasen mtqntlavtd iciiipskge spphtfckvd
      181 knlnnsmwgs avylcykksv aktntvsyka glicrypqed yesfslpesv plfclpmgat
      241 iecwpsnsky plpvfstfvl tgasaekvyg aaiqfyepys eenltekqrl llgltsadgk
      301 sdssktihtn kcicllshwp ffdafrkflt flyrysisgp hvlpiekhis hfmhkvpfps
      361 pqrprilvql sphdnlilsq pvssplplsg gkfstllqnl gpenavtllv favtehkili
      421 hslrpsvlts vtealvsmif pfhwpcpyvp lcplaladvl sapcpfivgi dsryfdlydp
      481 ppdvscvdvd tntisqigdk knvawkilpk kpcknlmntl nnlhqqlakl qqrprddglm
      541 dlaindydfn sgkrlhmidl eiqeaflffm asilkgyrsy lrpitqapse tatdaaslfa
      601 lqaflrsrdr shqkfynmmt ktqmfirfie ecsfvsdkda slaffddcvd kvdmdksgev
      661 rlieldesfk sehtvfvtpp eiphlpngee pplqysyngf pvlrnnlfer pegflqakkn
      721 klpskssspn splpmfrrtk qeiksahkia kryssipqmw srcllrhcyg lwficlpayv
      781 kvchskvral ktaydvlkkm qskkmdppde vcyrilmqlc gqydqpvlav rvlfemqkag
      841 idpnaitygy ynkavlestw psrsrsgyfl wtkvrnvvlg vtqfkralkk hahlsqttls
      901 adgsdldavs hgsmdsghgt htveqapfnt glikvyatdd rsstggqsdl gynslskdev
      961 rrgdtstedi qeekdkkgsd csslsesest kgsadclpkl syqnsssivr ltgtsnnsag
     1021 kisgesmest pelllissle dtnetrniqs rcfrkrhksd netnlqqqvv wgnrnrnlsg
     1081 gvlmgfmlnr inqeatpgdi veklgadaki lsnviskstr pntldigkpp lrskrdslek
     1141 essdddtpfd gsnyladkvd spvifdledl dsetdvskag cvatqnpkri qrmnssfsvk
     1201 pfektdvatg fdplsllvae teqqqkeeee ededdsksis tpsarrdlae eivmymnnms
     1261 spltsrtpsi dlqracddkl nkkspplvka crrsslppns pkpvrltksk sytkseekpr
     1321 drlwsspafs ptcpfreesq dtlthsspsf nldtllvpkl dvlrnsmfta gkgvaekask
     1381 wysrftmytt sskdqssdrt slssvgaqds estsltdedv chelegpiss qetsatsgtk
     1441 ridlsrisle ssaslegsls kfalpgksev tssfnasntn ifqnyamevl isscsrcrtc
     1501 dclvhdeeim agwtaddsnl nttcpfcgni flpflnieir dlrrpgryfl ksspstenmh
     1561 fpssissqtr qscistsasg ldtsalsvqg nfdlnskskl qenfctrsiq ipanrsktam
     1621 skcpifpmar sistsgpldk edtgrqklis tgslpatlqg atdslglewh lpspdpvtvp
     1681 ylsplvvwke lesllenegd haitvadfvd hhpivfwnlv wyfrrldlps nlpglilsse
     1741 hcnkyskipr hcmsedskyv liqmlwdnmk lhqdpgqply ilwnahsqsr tllfetqkyp
     1801 mvhllqksdn sfnqellksm vksikmndvy gpmsqiletl nkcphfkrqr slyreilfls
     1861 lvalgrenid idafdkeykm aydrltpsqv ksthncdrpp stgvmecrkt fgepyl
//
LOCUS       XP_047288045            1916 aa            linear   PRI 05-AUG-2025
DEFINITION  C-myc promoter-binding protein isoform X1 [Homo sapiens].
ACCESSION   XP_047288045
VERSION     XP_047288045.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432089.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1916
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1916
                     /product="C-myc promoter-binding protein isoform X1"
                     /calculated_mol_wt=214707
     Region          194..276
                     /region_name="uDENN"
                     /note="Domain always found upstream of DENN domain, found
                     in a variety of signalling proteins; smart00800"
                     /db_xref="CDD:214824"
     Region          308..492
                     /region_name="DENN"
                     /note="DENN (AEX-3) domain; pfam02141"
                     /db_xref="CDD:460461"
     Region          559..632
                     /region_name="dDENN"
                     /note="Domain always found downstream of DENN domain,
                     found in a variety of signalling proteins; smart00801"
                     /db_xref="CDD:129037"
     Region          808..848
                     /region_name="PPR_2"
                     /note="PPR repeat family; pfam13041"
                     /db_xref="CDD:463778"
     Region          810..839
                     /region_name="PPR repeat"
                     /note="PPR repeat [structural motif]"
                     /db_xref="CDD:276811"
     CDS             1..1916
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /coded_by="XM_047432089.1:469..6219"
                     /db_xref="GeneID:10260"
                     /db_xref="HGNC:HGNC:24321"
                     /db_xref="MIM:600382"
ORIGIN      
        1 miedkgprva dyfvvagltd vskpleeeih fndachkvak pkepitdvsv iikslgeevp
       61 qdyicidvtp tglsadlnng slvgpqiylc yrrgrdkppl tdlgvlydwk erlkqgceii
      121 qstpygrpan isgstssqri yityrrasen mtqntlavtd iciiipskge spphtfckvd
      181 knlnnsmwgs avylcykksv aktntvsyka glicrypqed yesfslpesv plfclpmgat
      241 iecwpsnsky plpvfstfvl tgasaekvyg aaiqfyepys eenltekqrl llgltsadgk
      301 sdssktihtn kcicllshwp ffdafrkflt flyrysisgp hvlpiekhis hfmhkvpfps
      361 pqrprilvql sphdnlilsq pvssplplsg gkfstllqnl gpenavtllv favtehkili
      421 hslrpsvlts vtealvsmif pfhwpcpyvp lcplaladvl sapcpfivgi dsryfdlydp
      481 ppdvscvdvd tntisqigdk knvawkilpk kpcknlmntl nnlhqqlakl qqrprddglm
      541 dlaindydfn sgkrlhmidl eiqeaflffm asilkgyrsy lrpitqapse tatdaaslfa
      601 lqaflrsrdr shqkfynmmt ktqmfirfie ecsfvsdkda slaffddcvd kvdmdksgev
      661 rlieldesfk sehtvfvtpp eiphlpngee pplqysyngf pvlrnnlfer pegflqakkn
      721 klpskssspn splpmfrrtk qeiksahkia kryssipqmw srcllrhcyg lwficlpayv
      781 kvchskvral ktaydvlkkm qskkmdppde vcyrilmqlc gqydqpvlav rvlfemqkag
      841 idpnaitygy ynkavlestw psrsrsgyfl wtkvrnvvlg vtqfkralkk hahlsqttls
      901 adgsdldavs hgsmdsghgt htveqapfnt glikvyatdd rsstggqsdl gynslskdev
      961 rrgdtstedi qeekdkkgsd csslsesest kgsadclpkl syqnsssivr ltgtsnnsag
     1021 kisgesmest pelllissle dtnetrniqs rcfrkrhksd netnlqqqvv wgnrnrnlsg
     1081 gvlmgfmlnr inqeatpgdi veklgadaki lsnviskstr pntldigkpp lrskrdslek
     1141 essdddtpfd gsnyladkvd spvifdledl dsetdvskag cvatqnpkri qrmnssfsvk
     1201 pfektdvatg fdplsllvae teqqqkeeee ededdsksis tpsarrdlae eivmymnnms
     1261 spltsrtpsi dlqracddkl nkkspplvka crrsslppns pkpvrltksk sytkseekpr
     1321 drlwsspafs ptcpfreesq dtlthsspsf nldtllvpkl dvlrnsmfta gkgvaekask
     1381 wysrftmytt sskdqssdrt slssvgaqds estsltdedv chelegpiss qetsatsgtk
     1441 ridlsrisle ssaslegsls kfalpgksev tssfnasntn ifqnyamevl isscsrcrtc
     1501 dclvhdeeim agwtaddsnl nttcpfcgni flpflnieir dlrrpgryfl ksspstenmh
     1561 fpssissqtr qscistsasg ldtsalsvqg nfdlnskskl qenfctrsiq ipanrsktam
     1621 skcpifpmar sistsgpldk edtgrqklis tgslpatlqg atdslglewh lpspdpvtvp
     1681 ylsplvvwke lesllenegd haitvadfvd hhpivfwnlv wyfrrldlps nlpglilsse
     1741 hcnkyskipr hcmsedskyv liqmlwdnmk lhqdpgqply ilwnahsqsr tllfetqkyp
     1801 mvhllqksdn sfnqellksm vksikmndvy gpmsqiletl nkcphfkrqr slyreilfls
     1861 lvalgrenid idafdkeykm aydrltpsqv ksthncdrpp stgvmecrkt fgepyl
//
LOCUS       XP_047288046            1915 aa            linear   PRI 05-AUG-2025
DEFINITION  C-myc promoter-binding protein isoform X2 [Homo sapiens].
ACCESSION   XP_047288046
VERSION     XP_047288046.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432090.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1915
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1915
                     /product="C-myc promoter-binding protein isoform X2"
                     /calculated_mol_wt=214636
     Region          194..276
                     /region_name="uDENN"
                     /note="Domain always found upstream of DENN domain, found
                     in a variety of signalling proteins; smart00800"
                     /db_xref="CDD:214824"
     Region          308..492
                     /region_name="DENN"
                     /note="DENN (AEX-3) domain; pfam02141"
                     /db_xref="CDD:460461"
     Region          559..632
                     /region_name="dDENN"
                     /note="Domain always found downstream of DENN domain,
                     found in a variety of signalling proteins; smart00801"
                     /db_xref="CDD:129037"
     Region          808..848
                     /region_name="PPR_2"
                     /note="PPR repeat family; pfam13041"
                     /db_xref="CDD:463778"
     Region          810..839
                     /region_name="PPR repeat"
                     /note="PPR repeat [structural motif]"
                     /db_xref="CDD:276811"
     CDS             1..1915
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /coded_by="XM_047432090.1:386..6133"
                     /db_xref="GeneID:10260"
                     /db_xref="HGNC:HGNC:24321"
                     /db_xref="MIM:600382"
ORIGIN      
        1 miedkgprva dyfvvagltd vskpleeeih fndachkvak pkepitdvsv iikslgeevp
       61 qdyicidvtp tglsadlnng slvgpqiylc yrrgrdkppl tdlgvlydwk erlkqgceii
      121 qstpygrpan isgstssqri yityrrasen mtqntlavtd iciiipskge spphtfckvd
      181 knlnnsmwgs avylcykksv aktntvsyka glicrypqed yesfslpesv plfclpmgat
      241 iecwpsnsky plpvfstfvl tgasaekvyg aaiqfyepys eenltekqrl llgltsadgk
      301 sdssktihtn kcicllshwp ffdafrkflt flyrysisgp hvlpiekhis hfmhkvpfps
      361 pqrprilvql sphdnlilsq pvssplplsg gkfstllqnl gpenavtllv favtehkili
      421 hslrpsvlts vtealvsmif pfhwpcpyvp lcplaladvl sapcpfivgi dsryfdlydp
      481 ppdvscvdvd tntisqigdk knvawkilpk kpcknlmntl nnlhqqlakl qqrprddglm
      541 dlaindydfn sgkrlhmidl eiqeaflffm asilkgyrsy lrpitqapse tatdaaslfa
      601 lqaflrsrdr shqkfynmmt ktqmfirfie ecsfvsdkda slaffddcvd kvdmdksgev
      661 rlieldesfk sehtvfvtpp eiphlpngee pplqysyngf pvlrnnlfer pegflqakkn
      721 klpskssspn splpmfrrtk qeiksahkia kryssipqmw srcllrhcyg lwficlpayv
      781 kvchskvral ktaydvlkkm qskkmdppde vcyrilmqlc gqydqpvlav rvlfemqkag
      841 idpnaitygy ynkavlestw psrsrsgyfl wtkvrnvvlg vtqfkralkk hahlsqttls
      901 dgsdldavsh gsmdsghgth tveqapfntg likvyatddr sstggqsdlg ynslskdevr
      961 rgdtstediq eekdkkgsdc sslsesestk gsadclpkls yqnsssivrl tgtsnnsagk
     1021 isgesmestp elllissled tnetrniqsr cfrkrhksdn etnlqqqvvw gnrnrnlsgg
     1081 vlmgfmlnri nqeatpgdiv eklgadakil snviskstrp ntldigkppl rskrdsleke
     1141 ssdddtpfdg snyladkvds pvifdledld setdvskagc vatqnpkriq rmnssfsvkp
     1201 fektdvatgf dplsllvaet eqqqkeeeee deddsksist psarrdlaee ivmymnnmss
     1261 pltsrtpsid lqracddkln kkspplvkac rrsslppnsp kpvrltksks ytkseekprd
     1321 rlwsspafsp tcpfreesqd tlthsspsfn ldtllvpkld vlrnsmftag kgvaekaskw
     1381 ysrftmytts skdqssdrts lssvgaqdse stsltdedvc helegpissq etsatsgtkr
     1441 idlsrisles saslegslsk falpgksevt ssfnasntni fqnyamevli sscsrcrtcd
     1501 clvhdeeima gwtaddsnln ttcpfcgnif lpflnieird lrrpgryflk sspstenmhf
     1561 pssissqtrq scistsasgl dtsalsvqgn fdlnsksklq enfctrsiqi panrsktams
     1621 kcpifpmars istsgpldke dtgrqklist gslpatlqga tdslglewhl pspdpvtvpy
     1681 lsplvvwkel esllenegdh aitvadfvdh hpivfwnlvw yfrrldlpsn lpglilsseh
     1741 cnkyskiprh cmsedskyvl iqmlwdnmkl hqdpgqplyi lwnahsqsrt llfetqkypm
     1801 vhllqksdns fnqellksmv ksikmndvyg pmsqiletln kcphfkrqrs lyreilflsl
     1861 valgrenidi dafdkeykma ydrltpsqvk sthncdrpps tgvmecrktf gepyl
//
LOCUS       XP_047288047            1915 aa            linear   PRI 05-AUG-2025
DEFINITION  C-myc promoter-binding protein isoform X2 [Homo sapiens].
ACCESSION   XP_047288047
VERSION     XP_047288047.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432091.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1915
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1915
                     /product="C-myc promoter-binding protein isoform X2"
                     /calculated_mol_wt=214636
     Region          194..276
                     /region_name="uDENN"
                     /note="Domain always found upstream of DENN domain, found
                     in a variety of signalling proteins; smart00800"
                     /db_xref="CDD:214824"
     Region          308..492
                     /region_name="DENN"
                     /note="DENN (AEX-3) domain; pfam02141"
                     /db_xref="CDD:460461"
     Region          559..632
                     /region_name="dDENN"
                     /note="Domain always found downstream of DENN domain,
                     found in a variety of signalling proteins; smart00801"
                     /db_xref="CDD:129037"
     Region          808..848
                     /region_name="PPR_2"
                     /note="PPR repeat family; pfam13041"
                     /db_xref="CDD:463778"
     Region          810..839
                     /region_name="PPR repeat"
                     /note="PPR repeat [structural motif]"
                     /db_xref="CDD:276811"
     CDS             1..1915
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /coded_by="XM_047432091.1:307..6054"
                     /db_xref="GeneID:10260"
                     /db_xref="HGNC:HGNC:24321"
                     /db_xref="MIM:600382"
ORIGIN      
        1 miedkgprva dyfvvagltd vskpleeeih fndachkvak pkepitdvsv iikslgeevp
       61 qdyicidvtp tglsadlnng slvgpqiylc yrrgrdkppl tdlgvlydwk erlkqgceii
      121 qstpygrpan isgstssqri yityrrasen mtqntlavtd iciiipskge spphtfckvd
      181 knlnnsmwgs avylcykksv aktntvsyka glicrypqed yesfslpesv plfclpmgat
      241 iecwpsnsky plpvfstfvl tgasaekvyg aaiqfyepys eenltekqrl llgltsadgk
      301 sdssktihtn kcicllshwp ffdafrkflt flyrysisgp hvlpiekhis hfmhkvpfps
      361 pqrprilvql sphdnlilsq pvssplplsg gkfstllqnl gpenavtllv favtehkili
      421 hslrpsvlts vtealvsmif pfhwpcpyvp lcplaladvl sapcpfivgi dsryfdlydp
      481 ppdvscvdvd tntisqigdk knvawkilpk kpcknlmntl nnlhqqlakl qqrprddglm
      541 dlaindydfn sgkrlhmidl eiqeaflffm asilkgyrsy lrpitqapse tatdaaslfa
      601 lqaflrsrdr shqkfynmmt ktqmfirfie ecsfvsdkda slaffddcvd kvdmdksgev
      661 rlieldesfk sehtvfvtpp eiphlpngee pplqysyngf pvlrnnlfer pegflqakkn
      721 klpskssspn splpmfrrtk qeiksahkia kryssipqmw srcllrhcyg lwficlpayv
      781 kvchskvral ktaydvlkkm qskkmdppde vcyrilmqlc gqydqpvlav rvlfemqkag
      841 idpnaitygy ynkavlestw psrsrsgyfl wtkvrnvvlg vtqfkralkk hahlsqttls
      901 dgsdldavsh gsmdsghgth tveqapfntg likvyatddr sstggqsdlg ynslskdevr
      961 rgdtstediq eekdkkgsdc sslsesestk gsadclpkls yqnsssivrl tgtsnnsagk
     1021 isgesmestp elllissled tnetrniqsr cfrkrhksdn etnlqqqvvw gnrnrnlsgg
     1081 vlmgfmlnri nqeatpgdiv eklgadakil snviskstrp ntldigkppl rskrdsleke
     1141 ssdddtpfdg snyladkvds pvifdledld setdvskagc vatqnpkriq rmnssfsvkp
     1201 fektdvatgf dplsllvaet eqqqkeeeee deddsksist psarrdlaee ivmymnnmss
     1261 pltsrtpsid lqracddkln kkspplvkac rrsslppnsp kpvrltksks ytkseekprd
     1321 rlwsspafsp tcpfreesqd tlthsspsfn ldtllvpkld vlrnsmftag kgvaekaskw
     1381 ysrftmytts skdqssdrts lssvgaqdse stsltdedvc helegpissq etsatsgtkr
     1441 idlsrisles saslegslsk falpgksevt ssfnasntni fqnyamevli sscsrcrtcd
     1501 clvhdeeima gwtaddsnln ttcpfcgnif lpflnieird lrrpgryflk sspstenmhf
     1561 pssissqtrq scistsasgl dtsalsvqgn fdlnsksklq enfctrsiqi panrsktams
     1621 kcpifpmars istsgpldke dtgrqklist gslpatlqga tdslglewhl pspdpvtvpy
     1681 lsplvvwkel esllenegdh aitvadfvdh hpivfwnlvw yfrrldlpsn lpglilsseh
     1741 cnkyskiprh cmsedskyvl iqmlwdnmkl hqdpgqplyi lwnahsqsrt llfetqkypm
     1801 vhllqksdns fnqellksmv ksikmndvyg pmsqiletln kcphfkrqrs lyreilflsl
     1861 valgrenidi dafdkeykma ydrltpsqvk sthncdrpps tgvmecrktf gepyl
//
LOCUS       XP_047288048            1915 aa            linear   PRI 05-AUG-2025
DEFINITION  C-myc promoter-binding protein isoform X2 [Homo sapiens].
ACCESSION   XP_047288048
VERSION     XP_047288048.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432092.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1915
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1915
                     /product="C-myc promoter-binding protein isoform X2"
                     /calculated_mol_wt=214636
     Region          194..276
                     /region_name="uDENN"
                     /note="Domain always found upstream of DENN domain, found
                     in a variety of signalling proteins; smart00800"
                     /db_xref="CDD:214824"
     Region          308..492
                     /region_name="DENN"
                     /note="DENN (AEX-3) domain; pfam02141"
                     /db_xref="CDD:460461"
     Region          559..632
                     /region_name="dDENN"
                     /note="Domain always found downstream of DENN domain,
                     found in a variety of signalling proteins; smart00801"
                     /db_xref="CDD:129037"
     Region          808..848
                     /region_name="PPR_2"
                     /note="PPR repeat family; pfam13041"
                     /db_xref="CDD:463778"
     Region          810..839
                     /region_name="PPR repeat"
                     /note="PPR repeat [structural motif]"
                     /db_xref="CDD:276811"
     CDS             1..1915
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /coded_by="XM_047432092.1:255..6002"
                     /db_xref="GeneID:10260"
                     /db_xref="HGNC:HGNC:24321"
                     /db_xref="MIM:600382"
ORIGIN      
        1 miedkgprva dyfvvagltd vskpleeeih fndachkvak pkepitdvsv iikslgeevp
       61 qdyicidvtp tglsadlnng slvgpqiylc yrrgrdkppl tdlgvlydwk erlkqgceii
      121 qstpygrpan isgstssqri yityrrasen mtqntlavtd iciiipskge spphtfckvd
      181 knlnnsmwgs avylcykksv aktntvsyka glicrypqed yesfslpesv plfclpmgat
      241 iecwpsnsky plpvfstfvl tgasaekvyg aaiqfyepys eenltekqrl llgltsadgk
      301 sdssktihtn kcicllshwp ffdafrkflt flyrysisgp hvlpiekhis hfmhkvpfps
      361 pqrprilvql sphdnlilsq pvssplplsg gkfstllqnl gpenavtllv favtehkili
      421 hslrpsvlts vtealvsmif pfhwpcpyvp lcplaladvl sapcpfivgi dsryfdlydp
      481 ppdvscvdvd tntisqigdk knvawkilpk kpcknlmntl nnlhqqlakl qqrprddglm
      541 dlaindydfn sgkrlhmidl eiqeaflffm asilkgyrsy lrpitqapse tatdaaslfa
      601 lqaflrsrdr shqkfynmmt ktqmfirfie ecsfvsdkda slaffddcvd kvdmdksgev
      661 rlieldesfk sehtvfvtpp eiphlpngee pplqysyngf pvlrnnlfer pegflqakkn
      721 klpskssspn splpmfrrtk qeiksahkia kryssipqmw srcllrhcyg lwficlpayv
      781 kvchskvral ktaydvlkkm qskkmdppde vcyrilmqlc gqydqpvlav rvlfemqkag
      841 idpnaitygy ynkavlestw psrsrsgyfl wtkvrnvvlg vtqfkralkk hahlsqttls
      901 dgsdldavsh gsmdsghgth tveqapfntg likvyatddr sstggqsdlg ynslskdevr
      961 rgdtstediq eekdkkgsdc sslsesestk gsadclpkls yqnsssivrl tgtsnnsagk
     1021 isgesmestp elllissled tnetrniqsr cfrkrhksdn etnlqqqvvw gnrnrnlsgg
     1081 vlmgfmlnri nqeatpgdiv eklgadakil snviskstrp ntldigkppl rskrdsleke
     1141 ssdddtpfdg snyladkvds pvifdledld setdvskagc vatqnpkriq rmnssfsvkp
     1201 fektdvatgf dplsllvaet eqqqkeeeee deddsksist psarrdlaee ivmymnnmss
     1261 pltsrtpsid lqracddkln kkspplvkac rrsslppnsp kpvrltksks ytkseekprd
     1321 rlwsspafsp tcpfreesqd tlthsspsfn ldtllvpkld vlrnsmftag kgvaekaskw
     1381 ysrftmytts skdqssdrts lssvgaqdse stsltdedvc helegpissq etsatsgtkr
     1441 idlsrisles saslegslsk falpgksevt ssfnasntni fqnyamevli sscsrcrtcd
     1501 clvhdeeima gwtaddsnln ttcpfcgnif lpflnieird lrrpgryflk sspstenmhf
     1561 pssissqtrq scistsasgl dtsalsvqgn fdlnsksklq enfctrsiqi panrsktams
     1621 kcpifpmars istsgpldke dtgrqklist gslpatlqga tdslglewhl pspdpvtvpy
     1681 lsplvvwkel esllenegdh aitvadfvdh hpivfwnlvw yfrrldlpsn lpglilsseh
     1741 cnkyskiprh cmsedskyvl iqmlwdnmkl hqdpgqplyi lwnahsqsrt llfetqkypm
     1801 vhllqksdns fnqellksmv ksikmndvyg pmsqiletln kcphfkrqrs lyreilflsl
     1861 valgrenidi dafdkeykma ydrltpsqvk sthncdrpps tgvmecrktf gepyl
//
LOCUS       XP_047288049            1915 aa            linear   PRI 05-AUG-2025
DEFINITION  C-myc promoter-binding protein isoform X2 [Homo sapiens].
ACCESSION   XP_047288049
VERSION     XP_047288049.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432093.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1915
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1915
                     /product="C-myc promoter-binding protein isoform X2"
                     /calculated_mol_wt=214636
     Region          194..276
                     /region_name="uDENN"
                     /note="Domain always found upstream of DENN domain, found
                     in a variety of signalling proteins; smart00800"
                     /db_xref="CDD:214824"
     Region          308..492
                     /region_name="DENN"
                     /note="DENN (AEX-3) domain; pfam02141"
                     /db_xref="CDD:460461"
     Region          559..632
                     /region_name="dDENN"
                     /note="Domain always found downstream of DENN domain,
                     found in a variety of signalling proteins; smart00801"
                     /db_xref="CDD:129037"
     Region          808..848
                     /region_name="PPR_2"
                     /note="PPR repeat family; pfam13041"
                     /db_xref="CDD:463778"
     Region          810..839
                     /region_name="PPR repeat"
                     /note="PPR repeat [structural motif]"
                     /db_xref="CDD:276811"
     CDS             1..1915
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /coded_by="XM_047432093.1:469..6216"
                     /db_xref="GeneID:10260"
                     /db_xref="HGNC:HGNC:24321"
                     /db_xref="MIM:600382"
ORIGIN      
        1 miedkgprva dyfvvagltd vskpleeeih fndachkvak pkepitdvsv iikslgeevp
       61 qdyicidvtp tglsadlnng slvgpqiylc yrrgrdkppl tdlgvlydwk erlkqgceii
      121 qstpygrpan isgstssqri yityrrasen mtqntlavtd iciiipskge spphtfckvd
      181 knlnnsmwgs avylcykksv aktntvsyka glicrypqed yesfslpesv plfclpmgat
      241 iecwpsnsky plpvfstfvl tgasaekvyg aaiqfyepys eenltekqrl llgltsadgk
      301 sdssktihtn kcicllshwp ffdafrkflt flyrysisgp hvlpiekhis hfmhkvpfps
      361 pqrprilvql sphdnlilsq pvssplplsg gkfstllqnl gpenavtllv favtehkili
      421 hslrpsvlts vtealvsmif pfhwpcpyvp lcplaladvl sapcpfivgi dsryfdlydp
      481 ppdvscvdvd tntisqigdk knvawkilpk kpcknlmntl nnlhqqlakl qqrprddglm
      541 dlaindydfn sgkrlhmidl eiqeaflffm asilkgyrsy lrpitqapse tatdaaslfa
      601 lqaflrsrdr shqkfynmmt ktqmfirfie ecsfvsdkda slaffddcvd kvdmdksgev
      661 rlieldesfk sehtvfvtpp eiphlpngee pplqysyngf pvlrnnlfer pegflqakkn
      721 klpskssspn splpmfrrtk qeiksahkia kryssipqmw srcllrhcyg lwficlpayv
      781 kvchskvral ktaydvlkkm qskkmdppde vcyrilmqlc gqydqpvlav rvlfemqkag
      841 idpnaitygy ynkavlestw psrsrsgyfl wtkvrnvvlg vtqfkralkk hahlsqttls
      901 dgsdldavsh gsmdsghgth tveqapfntg likvyatddr sstggqsdlg ynslskdevr
      961 rgdtstediq eekdkkgsdc sslsesestk gsadclpkls yqnsssivrl tgtsnnsagk
     1021 isgesmestp elllissled tnetrniqsr cfrkrhksdn etnlqqqvvw gnrnrnlsgg
     1081 vlmgfmlnri nqeatpgdiv eklgadakil snviskstrp ntldigkppl rskrdsleke
     1141 ssdddtpfdg snyladkvds pvifdledld setdvskagc vatqnpkriq rmnssfsvkp
     1201 fektdvatgf dplsllvaet eqqqkeeeee deddsksist psarrdlaee ivmymnnmss
     1261 pltsrtpsid lqracddkln kkspplvkac rrsslppnsp kpvrltksks ytkseekprd
     1321 rlwsspafsp tcpfreesqd tlthsspsfn ldtllvpkld vlrnsmftag kgvaekaskw
     1381 ysrftmytts skdqssdrts lssvgaqdse stsltdedvc helegpissq etsatsgtkr
     1441 idlsrisles saslegslsk falpgksevt ssfnasntni fqnyamevli sscsrcrtcd
     1501 clvhdeeima gwtaddsnln ttcpfcgnif lpflnieird lrrpgryflk sspstenmhf
     1561 pssissqtrq scistsasgl dtsalsvqgn fdlnsksklq enfctrsiqi panrsktams
     1621 kcpifpmars istsgpldke dtgrqklist gslpatlqga tdslglewhl pspdpvtvpy
     1681 lsplvvwkel esllenegdh aitvadfvdh hpivfwnlvw yfrrldlpsn lpglilsseh
     1741 cnkyskiprh cmsedskyvl iqmlwdnmkl hqdpgqplyi lwnahsqsrt llfetqkypm
     1801 vhllqksdns fnqellksmv ksikmndvyg pmsqiletln kcphfkrqrs lyreilflsl
     1861 valgrenidi dafdkeykma ydrltpsqvk sthncdrpps tgvmecrktf gepyl
//
LOCUS       XP_005254177            1907 aa            linear   PRI 05-AUG-2025
DEFINITION  C-myc promoter-binding protein isoform X3 [Homo sapiens].
ACCESSION   XP_005254177
VERSION     XP_005254177.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254120.6
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1907
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1907
                     /product="C-myc promoter-binding protein isoform X3"
                     /calculated_mol_wt=213645
     Region          194..276
                     /region_name="uDENN"
                     /note="Domain always found upstream of DENN domain, found
                     in a variety of signalling proteins; smart00800"
                     /db_xref="CDD:214824"
     Region          308..492
                     /region_name="DENN"
                     /note="DENN (AEX-3) domain; pfam02141"
                     /db_xref="CDD:460461"
     Region          559..632
                     /region_name="dDENN"
                     /note="Domain always found downstream of DENN domain,
                     found in a variety of signalling proteins; smart00801"
                     /db_xref="CDD:129037"
     Region          808..848
                     /region_name="PPR_2"
                     /note="PPR repeat family; pfam13041"
                     /db_xref="CDD:463778"
     Region          810..839
                     /region_name="PPR repeat"
                     /note="PPR repeat [structural motif]"
                     /db_xref="CDD:276811"
     CDS             1..1907
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /coded_by="XM_005254120.6:307..6030"
                     /db_xref="GeneID:10260"
                     /db_xref="HGNC:HGNC:24321"
                     /db_xref="MIM:600382"
ORIGIN      
        1 miedkgprva dyfvvagltd vskpleeeih fndachkvak pkepitdvsv iikslgeevp
       61 qdyicidvtp tglsadlnng slvgpqiylc yrrgrdkppl tdlgvlydwk erlkqgceii
      121 qstpygrpan isgstssqri yityrrasen mtqntlavtd iciiipskge spphtfckvd
      181 knlnnsmwgs avylcykksv aktntvsyka glicrypqed yesfslpesv plfclpmgat
      241 iecwpsnsky plpvfstfvl tgasaekvyg aaiqfyepys eenltekqrl llgltsadgk
      301 sdssktihtn kcicllshwp ffdafrkflt flyrysisgp hvlpiekhis hfmhkvpfps
      361 pqrprilvql sphdnlilsq pvssplplsg gkfstllqnl gpenavtllv favtehkili
      421 hslrpsvlts vtealvsmif pfhwpcpyvp lcplaladvl sapcpfivgi dsryfdlydp
      481 ppdvscvdvd tntisqigdk knvawkilpk kpcknlmntl nnlhqqlakl qqrprddglm
      541 dlaindydfn sgkrlhmidl eiqeaflffm asilkgyrsy lrpitqapse tatdaaslfa
      601 lqaflrsrdr shqkfynmmt ktqmfirfie ecsfvsdkda slaffddcvd kvdmdksgev
      661 rlieldesfk sehtvfvtpp eiphlpngee pplqysyngf pvlrnnlfer pegflqakkn
      721 klpskssspn splpmfrrtk qeiksahkia kryssipqmw srcllrhcyg lwficlpayv
      781 kvchskvral ktaydvlkkm qskkmdppde vcyrilmqlc gqydqpvlav rvlfemqkag
      841 idpnaitygy ynkavlestw psrsrsgyfl wtkvrnvvlg vtqfkralkk hahlsqttls
      901 adgsdldavs hgsmdsghgt htveqapfnt glikvyatdd rsstggqsdl gynslskdev
      961 rrgdtstedi qeekdkkgsd csslsesest kgsadclpkl syqnsssivr ltgtsnnsag
     1021 kisgesmest pelllissle dtnetrniqs rcfrkrhksd netnlqqqvv wgnrnrnlsg
     1081 gvlmgfmlnr inqeatpgdi veklgadaki lsnviskstr pntldigkpp lrskrdslek
     1141 essdddtpfd gsnyladkvd spvifdledl dsetdvskag cvatqnpkri qrmnssfsvk
     1201 pfektdvatg fdplsllvae teqqqkeeee ededdsksis tpsarrdlae eivmymnnms
     1261 spltsrtpsi dlqracddkl nkkspplvka crrsslppns pkpvrltksk sytkseekpr
     1321 drlwsspafs ptcpfreesq dtlthsspsf nldtllvpkl dvlrnsmfta gkgvaekask
     1381 wysrftmytt sskdqssdrt slssvgaqds estsltdedv chelegpiss qetsatsgtk
     1441 ridlsrisle ssaslegsls kfalpgksev tssfnasntn ifqnyamevl isscsrcrtc
     1501 dclvhdeeim agwtaddsnl nttcpfcgni flpflnieir dlrrpgryfl ksspstenmh
     1561 fpssissqtr qscistsasg ldtsalsvqg nfdlnskskl qenfctrsiq ipanrsktam
     1621 skcpifpmar sistsgpldk edtgrqklis tgslpatlqg atdslglewh lpspdpvtvp
     1681 ylsplvvwke lesllenegd haitvadfvd hhpivfwnlv wyfrrldlps nlpglilsse
     1741 hcnkyskipr hcmsedskyv liqmlwdnmk lhqdpgqply ilwnahtqky pmvhllqksd
     1801 nsfnqellks mvksikmndv ygpmsqilet lnkcphfkrq rslyreilfl slvalgreni
     1861 didafdkeyk maydrltpsq vksthncdrp pstgvmecrk tfgepyl
//
LOCUS       XP_047288050            1907 aa            linear   PRI 05-AUG-2025
DEFINITION  C-myc promoter-binding protein isoform X3 [Homo sapiens].
ACCESSION   XP_047288050
VERSION     XP_047288050.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432094.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1907
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1907
                     /product="C-myc promoter-binding protein isoform X3"
                     /calculated_mol_wt=213645
     Region          194..276
                     /region_name="uDENN"
                     /note="Domain always found upstream of DENN domain, found
                     in a variety of signalling proteins; smart00800"
                     /db_xref="CDD:214824"
     Region          308..492
                     /region_name="DENN"
                     /note="DENN (AEX-3) domain; pfam02141"
                     /db_xref="CDD:460461"
     Region          559..632
                     /region_name="dDENN"
                     /note="Domain always found downstream of DENN domain,
                     found in a variety of signalling proteins; smart00801"
                     /db_xref="CDD:129037"
     Region          808..848
                     /region_name="PPR_2"
                     /note="PPR repeat family; pfam13041"
                     /db_xref="CDD:463778"
     Region          810..839
                     /region_name="PPR repeat"
                     /note="PPR repeat [structural motif]"
                     /db_xref="CDD:276811"
     CDS             1..1907
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /coded_by="XM_047432094.1:469..6192"
                     /db_xref="GeneID:10260"
                     /db_xref="HGNC:HGNC:24321"
                     /db_xref="MIM:600382"
ORIGIN      
        1 miedkgprva dyfvvagltd vskpleeeih fndachkvak pkepitdvsv iikslgeevp
       61 qdyicidvtp tglsadlnng slvgpqiylc yrrgrdkppl tdlgvlydwk erlkqgceii
      121 qstpygrpan isgstssqri yityrrasen mtqntlavtd iciiipskge spphtfckvd
      181 knlnnsmwgs avylcykksv aktntvsyka glicrypqed yesfslpesv plfclpmgat
      241 iecwpsnsky plpvfstfvl tgasaekvyg aaiqfyepys eenltekqrl llgltsadgk
      301 sdssktihtn kcicllshwp ffdafrkflt flyrysisgp hvlpiekhis hfmhkvpfps
      361 pqrprilvql sphdnlilsq pvssplplsg gkfstllqnl gpenavtllv favtehkili
      421 hslrpsvlts vtealvsmif pfhwpcpyvp lcplaladvl sapcpfivgi dsryfdlydp
      481 ppdvscvdvd tntisqigdk knvawkilpk kpcknlmntl nnlhqqlakl qqrprddglm
      541 dlaindydfn sgkrlhmidl eiqeaflffm asilkgyrsy lrpitqapse tatdaaslfa
      601 lqaflrsrdr shqkfynmmt ktqmfirfie ecsfvsdkda slaffddcvd kvdmdksgev
      661 rlieldesfk sehtvfvtpp eiphlpngee pplqysyngf pvlrnnlfer pegflqakkn
      721 klpskssspn splpmfrrtk qeiksahkia kryssipqmw srcllrhcyg lwficlpayv
      781 kvchskvral ktaydvlkkm qskkmdppde vcyrilmqlc gqydqpvlav rvlfemqkag
      841 idpnaitygy ynkavlestw psrsrsgyfl wtkvrnvvlg vtqfkralkk hahlsqttls
      901 adgsdldavs hgsmdsghgt htveqapfnt glikvyatdd rsstggqsdl gynslskdev
      961 rrgdtstedi qeekdkkgsd csslsesest kgsadclpkl syqnsssivr ltgtsnnsag
     1021 kisgesmest pelllissle dtnetrniqs rcfrkrhksd netnlqqqvv wgnrnrnlsg
     1081 gvlmgfmlnr inqeatpgdi veklgadaki lsnviskstr pntldigkpp lrskrdslek
     1141 essdddtpfd gsnyladkvd spvifdledl dsetdvskag cvatqnpkri qrmnssfsvk
     1201 pfektdvatg fdplsllvae teqqqkeeee ededdsksis tpsarrdlae eivmymnnms
     1261 spltsrtpsi dlqracddkl nkkspplvka crrsslppns pkpvrltksk sytkseekpr
     1321 drlwsspafs ptcpfreesq dtlthsspsf nldtllvpkl dvlrnsmfta gkgvaekask
     1381 wysrftmytt sskdqssdrt slssvgaqds estsltdedv chelegpiss qetsatsgtk
     1441 ridlsrisle ssaslegsls kfalpgksev tssfnasntn ifqnyamevl isscsrcrtc
     1501 dclvhdeeim agwtaddsnl nttcpfcgni flpflnieir dlrrpgryfl ksspstenmh
     1561 fpssissqtr qscistsasg ldtsalsvqg nfdlnskskl qenfctrsiq ipanrsktam
     1621 skcpifpmar sistsgpldk edtgrqklis tgslpatlqg atdslglewh lpspdpvtvp
     1681 ylsplvvwke lesllenegd haitvadfvd hhpivfwnlv wyfrrldlps nlpglilsse
     1741 hcnkyskipr hcmsedskyv liqmlwdnmk lhqdpgqply ilwnahtqky pmvhllqksd
     1801 nsfnqellks mvksikmndv ygpmsqilet lnkcphfkrq rslyreilfl slvalgreni
     1861 didafdkeyk maydrltpsq vksthncdrp pstgvmecrk tfgepyl
//
LOCUS       XP_047288051            1906 aa            linear   PRI 05-AUG-2025
DEFINITION  C-myc promoter-binding protein isoform X4 [Homo sapiens].
ACCESSION   XP_047288051
VERSION     XP_047288051.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432095.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1906
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1906
                     /product="C-myc promoter-binding protein isoform X4"
                     /calculated_mol_wt=213574
     Region          194..276
                     /region_name="uDENN"
                     /note="Domain always found upstream of DENN domain, found
                     in a variety of signalling proteins; smart00800"
                     /db_xref="CDD:214824"
     Region          308..492
                     /region_name="DENN"
                     /note="DENN (AEX-3) domain; pfam02141"
                     /db_xref="CDD:460461"
     Region          559..632
                     /region_name="dDENN"
                     /note="Domain always found downstream of DENN domain,
                     found in a variety of signalling proteins; smart00801"
                     /db_xref="CDD:129037"
     Region          808..848
                     /region_name="PPR_2"
                     /note="PPR repeat family; pfam13041"
                     /db_xref="CDD:463778"
     Region          810..839
                     /region_name="PPR repeat"
                     /note="PPR repeat [structural motif]"
                     /db_xref="CDD:276811"
     CDS             1..1906
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /coded_by="XM_047432095.1:255..5975"
                     /db_xref="GeneID:10260"
                     /db_xref="HGNC:HGNC:24321"
                     /db_xref="MIM:600382"
ORIGIN      
        1 miedkgprva dyfvvagltd vskpleeeih fndachkvak pkepitdvsv iikslgeevp
       61 qdyicidvtp tglsadlnng slvgpqiylc yrrgrdkppl tdlgvlydwk erlkqgceii
      121 qstpygrpan isgstssqri yityrrasen mtqntlavtd iciiipskge spphtfckvd
      181 knlnnsmwgs avylcykksv aktntvsyka glicrypqed yesfslpesv plfclpmgat
      241 iecwpsnsky plpvfstfvl tgasaekvyg aaiqfyepys eenltekqrl llgltsadgk
      301 sdssktihtn kcicllshwp ffdafrkflt flyrysisgp hvlpiekhis hfmhkvpfps
      361 pqrprilvql sphdnlilsq pvssplplsg gkfstllqnl gpenavtllv favtehkili
      421 hslrpsvlts vtealvsmif pfhwpcpyvp lcplaladvl sapcpfivgi dsryfdlydp
      481 ppdvscvdvd tntisqigdk knvawkilpk kpcknlmntl nnlhqqlakl qqrprddglm
      541 dlaindydfn sgkrlhmidl eiqeaflffm asilkgyrsy lrpitqapse tatdaaslfa
      601 lqaflrsrdr shqkfynmmt ktqmfirfie ecsfvsdkda slaffddcvd kvdmdksgev
      661 rlieldesfk sehtvfvtpp eiphlpngee pplqysyngf pvlrnnlfer pegflqakkn
      721 klpskssspn splpmfrrtk qeiksahkia kryssipqmw srcllrhcyg lwficlpayv
      781 kvchskvral ktaydvlkkm qskkmdppde vcyrilmqlc gqydqpvlav rvlfemqkag
      841 idpnaitygy ynkavlestw psrsrsgyfl wtkvrnvvlg vtqfkralkk hahlsqttls
      901 dgsdldavsh gsmdsghgth tveqapfntg likvyatddr sstggqsdlg ynslskdevr
      961 rgdtstediq eekdkkgsdc sslsesestk gsadclpkls yqnsssivrl tgtsnnsagk
     1021 isgesmestp elllissled tnetrniqsr cfrkrhksdn etnlqqqvvw gnrnrnlsgg
     1081 vlmgfmlnri nqeatpgdiv eklgadakil snviskstrp ntldigkppl rskrdsleke
     1141 ssdddtpfdg snyladkvds pvifdledld setdvskagc vatqnpkriq rmnssfsvkp
     1201 fektdvatgf dplsllvaet eqqqkeeeee deddsksist psarrdlaee ivmymnnmss
     1261 pltsrtpsid lqracddkln kkspplvkac rrsslppnsp kpvrltksks ytkseekprd
     1321 rlwsspafsp tcpfreesqd tlthsspsfn ldtllvpkld vlrnsmftag kgvaekaskw
     1381 ysrftmytts skdqssdrts lssvgaqdse stsltdedvc helegpissq etsatsgtkr
     1441 idlsrisles saslegslsk falpgksevt ssfnasntni fqnyamevli sscsrcrtcd
     1501 clvhdeeima gwtaddsnln ttcpfcgnif lpflnieird lrrpgryflk sspstenmhf
     1561 pssissqtrq scistsasgl dtsalsvqgn fdlnsksklq enfctrsiqi panrsktams
     1621 kcpifpmars istsgpldke dtgrqklist gslpatlqga tdslglewhl pspdpvtvpy
     1681 lsplvvwkel esllenegdh aitvadfvdh hpivfwnlvw yfrrldlpsn lpglilsseh
     1741 cnkyskiprh cmsedskyvl iqmlwdnmkl hqdpgqplyi lwnahtqkyp mvhllqksdn
     1801 sfnqellksm vksikmndvy gpmsqiletl nkcphfkrqr slyreilfls lvalgrenid
     1861 idafdkeykm aydrltpsqv ksthncdrpp stgvmecrkt fgepyl
//
LOCUS       XP_047288052            1906 aa            linear   PRI 05-AUG-2025
DEFINITION  C-myc promoter-binding protein isoform X4 [Homo sapiens].
ACCESSION   XP_047288052
VERSION     XP_047288052.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432096.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1906
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1906
                     /product="C-myc promoter-binding protein isoform X4"
                     /calculated_mol_wt=213574
     Region          194..276
                     /region_name="uDENN"
                     /note="Domain always found upstream of DENN domain, found
                     in a variety of signalling proteins; smart00800"
                     /db_xref="CDD:214824"
     Region          308..492
                     /region_name="DENN"
                     /note="DENN (AEX-3) domain; pfam02141"
                     /db_xref="CDD:460461"
     Region          559..632
                     /region_name="dDENN"
                     /note="Domain always found downstream of DENN domain,
                     found in a variety of signalling proteins; smart00801"
                     /db_xref="CDD:129037"
     Region          808..848
                     /region_name="PPR_2"
                     /note="PPR repeat family; pfam13041"
                     /db_xref="CDD:463778"
     Region          810..839
                     /region_name="PPR repeat"
                     /note="PPR repeat [structural motif]"
                     /db_xref="CDD:276811"
     CDS             1..1906
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /coded_by="XM_047432096.1:469..6189"
                     /db_xref="GeneID:10260"
                     /db_xref="HGNC:HGNC:24321"
                     /db_xref="MIM:600382"
ORIGIN      
        1 miedkgprva dyfvvagltd vskpleeeih fndachkvak pkepitdvsv iikslgeevp
       61 qdyicidvtp tglsadlnng slvgpqiylc yrrgrdkppl tdlgvlydwk erlkqgceii
      121 qstpygrpan isgstssqri yityrrasen mtqntlavtd iciiipskge spphtfckvd
      181 knlnnsmwgs avylcykksv aktntvsyka glicrypqed yesfslpesv plfclpmgat
      241 iecwpsnsky plpvfstfvl tgasaekvyg aaiqfyepys eenltekqrl llgltsadgk
      301 sdssktihtn kcicllshwp ffdafrkflt flyrysisgp hvlpiekhis hfmhkvpfps
      361 pqrprilvql sphdnlilsq pvssplplsg gkfstllqnl gpenavtllv favtehkili
      421 hslrpsvlts vtealvsmif pfhwpcpyvp lcplaladvl sapcpfivgi dsryfdlydp
      481 ppdvscvdvd tntisqigdk knvawkilpk kpcknlmntl nnlhqqlakl qqrprddglm
      541 dlaindydfn sgkrlhmidl eiqeaflffm asilkgyrsy lrpitqapse tatdaaslfa
      601 lqaflrsrdr shqkfynmmt ktqmfirfie ecsfvsdkda slaffddcvd kvdmdksgev
      661 rlieldesfk sehtvfvtpp eiphlpngee pplqysyngf pvlrnnlfer pegflqakkn
      721 klpskssspn splpmfrrtk qeiksahkia kryssipqmw srcllrhcyg lwficlpayv
      781 kvchskvral ktaydvlkkm qskkmdppde vcyrilmqlc gqydqpvlav rvlfemqkag
      841 idpnaitygy ynkavlestw psrsrsgyfl wtkvrnvvlg vtqfkralkk hahlsqttls
      901 dgsdldavsh gsmdsghgth tveqapfntg likvyatddr sstggqsdlg ynslskdevr
      961 rgdtstediq eekdkkgsdc sslsesestk gsadclpkls yqnsssivrl tgtsnnsagk
     1021 isgesmestp elllissled tnetrniqsr cfrkrhksdn etnlqqqvvw gnrnrnlsgg
     1081 vlmgfmlnri nqeatpgdiv eklgadakil snviskstrp ntldigkppl rskrdsleke
     1141 ssdddtpfdg snyladkvds pvifdledld setdvskagc vatqnpkriq rmnssfsvkp
     1201 fektdvatgf dplsllvaet eqqqkeeeee deddsksist psarrdlaee ivmymnnmss
     1261 pltsrtpsid lqracddkln kkspplvkac rrsslppnsp kpvrltksks ytkseekprd
     1321 rlwsspafsp tcpfreesqd tlthsspsfn ldtllvpkld vlrnsmftag kgvaekaskw
     1381 ysrftmytts skdqssdrts lssvgaqdse stsltdedvc helegpissq etsatsgtkr
     1441 idlsrisles saslegslsk falpgksevt ssfnasntni fqnyamevli sscsrcrtcd
     1501 clvhdeeima gwtaddsnln ttcpfcgnif lpflnieird lrrpgryflk sspstenmhf
     1561 pssissqtrq scistsasgl dtsalsvqgn fdlnsksklq enfctrsiqi panrsktams
     1621 kcpifpmars istsgpldke dtgrqklist gslpatlqga tdslglewhl pspdpvtvpy
     1681 lsplvvwkel esllenegdh aitvadfvdh hpivfwnlvw yfrrldlpsn lpglilsseh
     1741 cnkyskiprh cmsedskyvl iqmlwdnmkl hqdpgqplyi lwnahtqkyp mvhllqksdn
     1801 sfnqellksm vksikmndvy gpmsqiletl nkcphfkrqr slyreilfls lvalgrenid
     1861 idafdkeykm aydrltpsqv ksthncdrpp stgvmecrkt fgepyl
//
LOCUS       XP_047288053            1906 aa            linear   PRI 05-AUG-2025
DEFINITION  C-myc promoter-binding protein isoform X4 [Homo sapiens].
ACCESSION   XP_047288053
VERSION     XP_047288053.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432097.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1906
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1906
                     /product="C-myc promoter-binding protein isoform X4"
                     /calculated_mol_wt=213574
     Region          194..276
                     /region_name="uDENN"
                     /note="Domain always found upstream of DENN domain, found
                     in a variety of signalling proteins; smart00800"
                     /db_xref="CDD:214824"
     Region          308..492
                     /region_name="DENN"
                     /note="DENN (AEX-3) domain; pfam02141"
                     /db_xref="CDD:460461"
     Region          559..632
                     /region_name="dDENN"
                     /note="Domain always found downstream of DENN domain,
                     found in a variety of signalling proteins; smart00801"
                     /db_xref="CDD:129037"
     Region          808..848
                     /region_name="PPR_2"
                     /note="PPR repeat family; pfam13041"
                     /db_xref="CDD:463778"
     Region          810..839
                     /region_name="PPR repeat"
                     /note="PPR repeat [structural motif]"
                     /db_xref="CDD:276811"
     CDS             1..1906
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /coded_by="XM_047432097.1:307..6027"
                     /db_xref="GeneID:10260"
                     /db_xref="HGNC:HGNC:24321"
                     /db_xref="MIM:600382"
ORIGIN      
        1 miedkgprva dyfvvagltd vskpleeeih fndachkvak pkepitdvsv iikslgeevp
       61 qdyicidvtp tglsadlnng slvgpqiylc yrrgrdkppl tdlgvlydwk erlkqgceii
      121 qstpygrpan isgstssqri yityrrasen mtqntlavtd iciiipskge spphtfckvd
      181 knlnnsmwgs avylcykksv aktntvsyka glicrypqed yesfslpesv plfclpmgat
      241 iecwpsnsky plpvfstfvl tgasaekvyg aaiqfyepys eenltekqrl llgltsadgk
      301 sdssktihtn kcicllshwp ffdafrkflt flyrysisgp hvlpiekhis hfmhkvpfps
      361 pqrprilvql sphdnlilsq pvssplplsg gkfstllqnl gpenavtllv favtehkili
      421 hslrpsvlts vtealvsmif pfhwpcpyvp lcplaladvl sapcpfivgi dsryfdlydp
      481 ppdvscvdvd tntisqigdk knvawkilpk kpcknlmntl nnlhqqlakl qqrprddglm
      541 dlaindydfn sgkrlhmidl eiqeaflffm asilkgyrsy lrpitqapse tatdaaslfa
      601 lqaflrsrdr shqkfynmmt ktqmfirfie ecsfvsdkda slaffddcvd kvdmdksgev
      661 rlieldesfk sehtvfvtpp eiphlpngee pplqysyngf pvlrnnlfer pegflqakkn
      721 klpskssspn splpmfrrtk qeiksahkia kryssipqmw srcllrhcyg lwficlpayv
      781 kvchskvral ktaydvlkkm qskkmdppde vcyrilmqlc gqydqpvlav rvlfemqkag
      841 idpnaitygy ynkavlestw psrsrsgyfl wtkvrnvvlg vtqfkralkk hahlsqttls
      901 dgsdldavsh gsmdsghgth tveqapfntg likvyatddr sstggqsdlg ynslskdevr
      961 rgdtstediq eekdkkgsdc sslsesestk gsadclpkls yqnsssivrl tgtsnnsagk
     1021 isgesmestp elllissled tnetrniqsr cfrkrhksdn etnlqqqvvw gnrnrnlsgg
     1081 vlmgfmlnri nqeatpgdiv eklgadakil snviskstrp ntldigkppl rskrdsleke
     1141 ssdddtpfdg snyladkvds pvifdledld setdvskagc vatqnpkriq rmnssfsvkp
     1201 fektdvatgf dplsllvaet eqqqkeeeee deddsksist psarrdlaee ivmymnnmss
     1261 pltsrtpsid lqracddkln kkspplvkac rrsslppnsp kpvrltksks ytkseekprd
     1321 rlwsspafsp tcpfreesqd tlthsspsfn ldtllvpkld vlrnsmftag kgvaekaskw
     1381 ysrftmytts skdqssdrts lssvgaqdse stsltdedvc helegpissq etsatsgtkr
     1441 idlsrisles saslegslsk falpgksevt ssfnasntni fqnyamevli sscsrcrtcd
     1501 clvhdeeima gwtaddsnln ttcpfcgnif lpflnieird lrrpgryflk sspstenmhf
     1561 pssissqtrq scistsasgl dtsalsvqgn fdlnsksklq enfctrsiqi panrsktams
     1621 kcpifpmars istsgpldke dtgrqklist gslpatlqga tdslglewhl pspdpvtvpy
     1681 lsplvvwkel esllenegdh aitvadfvdh hpivfwnlvw yfrrldlpsn lpglilsseh
     1741 cnkyskiprh cmsedskyvl iqmlwdnmkl hqdpgqplyi lwnahtqkyp mvhllqksdn
     1801 sfnqellksm vksikmndvy gpmsqiletl nkcphfkrqr slyreilfls lvalgrenid
     1861 idafdkeykm aydrltpsqv ksthncdrpp stgvmecrkt fgepyl
//
LOCUS       XP_047288054            1872 aa            linear   PRI 05-AUG-2025
DEFINITION  C-myc promoter-binding protein isoform X5 [Homo sapiens].
ACCESSION   XP_047288054
VERSION     XP_047288054.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432098.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1872
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1872
                     /product="C-myc promoter-binding protein isoform X5"
                     /calculated_mol_wt=210176
     Region          194..276
                     /region_name="uDENN"
                     /note="Domain always found upstream of DENN domain, found
                     in a variety of signalling proteins; smart00800"
                     /db_xref="CDD:214824"
     Region          308..492
                     /region_name="DENN"
                     /note="DENN (AEX-3) domain; pfam02141"
                     /db_xref="CDD:460461"
     Region          559..632
                     /region_name="dDENN"
                     /note="Domain always found downstream of DENN domain,
                     found in a variety of signalling proteins; smart00801"
                     /db_xref="CDD:129037"
     Region          808..848
                     /region_name="PPR_2"
                     /note="PPR repeat family; pfam13041"
                     /db_xref="CDD:463778"
     Region          810..839
                     /region_name="PPR repeat"
                     /note="PPR repeat [structural motif]"
                     /db_xref="CDD:276811"
     CDS             1..1872
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /coded_by="XM_047432098.1:386..6004"
                     /db_xref="GeneID:10260"
                     /db_xref="HGNC:HGNC:24321"
                     /db_xref="MIM:600382"
ORIGIN      
        1 miedkgprva dyfvvagltd vskpleeeih fndachkvak pkepitdvsv iikslgeevp
       61 qdyicidvtp tglsadlnng slvgpqiylc yrrgrdkppl tdlgvlydwk erlkqgceii
      121 qstpygrpan isgstssqri yityrrasen mtqntlavtd iciiipskge spphtfckvd
      181 knlnnsmwgs avylcykksv aktntvsyka glicrypqed yesfslpesv plfclpmgat
      241 iecwpsnsky plpvfstfvl tgasaekvyg aaiqfyepys eenltekqrl llgltsadgk
      301 sdssktihtn kcicllshwp ffdafrkflt flyrysisgp hvlpiekhis hfmhkvpfps
      361 pqrprilvql sphdnlilsq pvssplplsg gkfstllqnl gpenavtllv favtehkili
      421 hslrpsvlts vtealvsmif pfhwpcpyvp lcplaladvl sapcpfivgi dsryfdlydp
      481 ppdvscvdvd tntisqigdk knvawkilpk kpcknlmntl nnlhqqlakl qqrprddglm
      541 dlaindydfn sgkrlhmidl eiqeaflffm asilkgyrsy lrpitqapse tatdaaslfa
      601 lqaflrsrdr shqkfynmmt ktqmfirfie ecsfvsdkda slaffddcvd kvdmdksgev
      661 rlieldesfk sehtvfvtpp eiphlpngee pplqysyngf pvlrnnlfer pegflqakkn
      721 klpskssspn splpmfrrtk qeiksahkia kryssipqmw srcllrhcyg lwficlpayv
      781 kvchskvral ktaydvlkkm qskkmdppde vcyrilmqlc gqydqpvlav rvlfemqkag
      841 idpnaitygy ynkavlestw psrsrsgyfl wtkvrnvvlg vtqfkralkk hahlsqttls
      901 ggqsdlgyns lskdevrrgd tstediqeek dkkgsdcssl sesestkgsa dclpklsyqn
      961 sssivrltgt snnsagkisg esmestpell lissledtne trniqsrcfr krhksdnetn
     1021 lqqqvvwgnr nrnlsggvlm gfmlnrinqe atpgdivekl gadakilsnv iskstrpntl
     1081 digkpplrsk rdslekessd ddtpfdgsny ladkvdspvi fdledldset dvskagcvat
     1141 qnpkriqrmn ssfsvkpfek tdvatgfdpl sllvaeteqq qkeeeeeded dsksistpsa
     1201 rrdlaeeivm ymnnmssplt srtpsidlqr acddklnkks pplvkacrrs slppnspkpv
     1261 rltksksytk seekprdrlw sspafsptcp freesqdtlt hsspsfnldt llvpkldvlr
     1321 nsmftagkgv aekaskwysr ftmyttsskd qssdrtslss vgaqdsests ltdedvchel
     1381 egpissqets atsgtkridl srislessas legslskfal pgksevtssf nasntnifqn
     1441 yamevlissc srcrtcdclv hdeeimagwt addsnlnttc pfcgniflpf lnieirdlrr
     1501 pgryflkssp stenmhfpss issqtrqsci stsasgldts alsvqgnfdl nsksklqenf
     1561 ctrsiqipan rsktamskcp ifpmarsist sgpldkedtg rqklistgsl patlqgatds
     1621 lglewhlpsp dpvtvpylsp lvvwkelesl lenegdhait vadfvdhhpi vfwnlvwyfr
     1681 rldlpsnlpg lilssehcnk yskiprhcms edskyvliqm lwdnmklhqd pgqplyilwn
     1741 ahsqsrtllf etqkypmvhl lqksdnsfnq ellksmvksi kmndvygpms qiletlnkcp
     1801 hfkrqrslyr eilflslval grenididaf dkeykmaydr ltpsqvksth ncdrppstgv
     1861 mecrktfgep yl
//
LOCUS       XP_047288055            1872 aa            linear   PRI 05-AUG-2025
DEFINITION  C-myc promoter-binding protein isoform X5 [Homo sapiens].
ACCESSION   XP_047288055
VERSION     XP_047288055.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432099.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1872
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1872
                     /product="C-myc promoter-binding protein isoform X5"
                     /calculated_mol_wt=210176
     Region          194..276
                     /region_name="uDENN"
                     /note="Domain always found upstream of DENN domain, found
                     in a variety of signalling proteins; smart00800"
                     /db_xref="CDD:214824"
     Region          308..492
                     /region_name="DENN"
                     /note="DENN (AEX-3) domain; pfam02141"
                     /db_xref="CDD:460461"
     Region          559..632
                     /region_name="dDENN"
                     /note="Domain always found downstream of DENN domain,
                     found in a variety of signalling proteins; smart00801"
                     /db_xref="CDD:129037"
     Region          808..848
                     /region_name="PPR_2"
                     /note="PPR repeat family; pfam13041"
                     /db_xref="CDD:463778"
     Region          810..839
                     /region_name="PPR repeat"
                     /note="PPR repeat [structural motif]"
                     /db_xref="CDD:276811"
     CDS             1..1872
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /coded_by="XM_047432099.1:255..5873"
                     /db_xref="GeneID:10260"
                     /db_xref="HGNC:HGNC:24321"
                     /db_xref="MIM:600382"
ORIGIN      
        1 miedkgprva dyfvvagltd vskpleeeih fndachkvak pkepitdvsv iikslgeevp
       61 qdyicidvtp tglsadlnng slvgpqiylc yrrgrdkppl tdlgvlydwk erlkqgceii
      121 qstpygrpan isgstssqri yityrrasen mtqntlavtd iciiipskge spphtfckvd
      181 knlnnsmwgs avylcykksv aktntvsyka glicrypqed yesfslpesv plfclpmgat
      241 iecwpsnsky plpvfstfvl tgasaekvyg aaiqfyepys eenltekqrl llgltsadgk
      301 sdssktihtn kcicllshwp ffdafrkflt flyrysisgp hvlpiekhis hfmhkvpfps
      361 pqrprilvql sphdnlilsq pvssplplsg gkfstllqnl gpenavtllv favtehkili
      421 hslrpsvlts vtealvsmif pfhwpcpyvp lcplaladvl sapcpfivgi dsryfdlydp
      481 ppdvscvdvd tntisqigdk knvawkilpk kpcknlmntl nnlhqqlakl qqrprddglm
      541 dlaindydfn sgkrlhmidl eiqeaflffm asilkgyrsy lrpitqapse tatdaaslfa
      601 lqaflrsrdr shqkfynmmt ktqmfirfie ecsfvsdkda slaffddcvd kvdmdksgev
      661 rlieldesfk sehtvfvtpp eiphlpngee pplqysyngf pvlrnnlfer pegflqakkn
      721 klpskssspn splpmfrrtk qeiksahkia kryssipqmw srcllrhcyg lwficlpayv
      781 kvchskvral ktaydvlkkm qskkmdppde vcyrilmqlc gqydqpvlav rvlfemqkag
      841 idpnaitygy ynkavlestw psrsrsgyfl wtkvrnvvlg vtqfkralkk hahlsqttls
      901 ggqsdlgyns lskdevrrgd tstediqeek dkkgsdcssl sesestkgsa dclpklsyqn
      961 sssivrltgt snnsagkisg esmestpell lissledtne trniqsrcfr krhksdnetn
     1021 lqqqvvwgnr nrnlsggvlm gfmlnrinqe atpgdivekl gadakilsnv iskstrpntl
     1081 digkpplrsk rdslekessd ddtpfdgsny ladkvdspvi fdledldset dvskagcvat
     1141 qnpkriqrmn ssfsvkpfek tdvatgfdpl sllvaeteqq qkeeeeeded dsksistpsa
     1201 rrdlaeeivm ymnnmssplt srtpsidlqr acddklnkks pplvkacrrs slppnspkpv
     1261 rltksksytk seekprdrlw sspafsptcp freesqdtlt hsspsfnldt llvpkldvlr
     1321 nsmftagkgv aekaskwysr ftmyttsskd qssdrtslss vgaqdsests ltdedvchel
     1381 egpissqets atsgtkridl srislessas legslskfal pgksevtssf nasntnifqn
     1441 yamevlissc srcrtcdclv hdeeimagwt addsnlnttc pfcgniflpf lnieirdlrr
     1501 pgryflkssp stenmhfpss issqtrqsci stsasgldts alsvqgnfdl nsksklqenf
     1561 ctrsiqipan rsktamskcp ifpmarsist sgpldkedtg rqklistgsl patlqgatds
     1621 lglewhlpsp dpvtvpylsp lvvwkelesl lenegdhait vadfvdhhpi vfwnlvwyfr
     1681 rldlpsnlpg lilssehcnk yskiprhcms edskyvliqm lwdnmklhqd pgqplyilwn
     1741 ahsqsrtllf etqkypmvhl lqksdnsfnq ellksmvksi kmndvygpms qiletlnkcp
     1801 hfkrqrslyr eilflslval grenididaf dkeykmaydr ltpsqvksth ncdrppstgv
     1861 mecrktfgep yl
//
LOCUS       XP_047288056            1872 aa            linear   PRI 05-AUG-2025
DEFINITION  C-myc promoter-binding protein isoform X5 [Homo sapiens].
ACCESSION   XP_047288056
VERSION     XP_047288056.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432100.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1872
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1872
                     /product="C-myc promoter-binding protein isoform X5"
                     /calculated_mol_wt=210176
     Region          194..276
                     /region_name="uDENN"
                     /note="Domain always found upstream of DENN domain, found
                     in a variety of signalling proteins; smart00800"
                     /db_xref="CDD:214824"
     Region          308..492
                     /region_name="DENN"
                     /note="DENN (AEX-3) domain; pfam02141"
                     /db_xref="CDD:460461"
     Region          559..632
                     /region_name="dDENN"
                     /note="Domain always found downstream of DENN domain,
                     found in a variety of signalling proteins; smart00801"
                     /db_xref="CDD:129037"
     Region          808..848
                     /region_name="PPR_2"
                     /note="PPR repeat family; pfam13041"
                     /db_xref="CDD:463778"
     Region          810..839
                     /region_name="PPR repeat"
                     /note="PPR repeat [structural motif]"
                     /db_xref="CDD:276811"
     CDS             1..1872
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /coded_by="XM_047432100.1:307..5925"
                     /db_xref="GeneID:10260"
                     /db_xref="HGNC:HGNC:24321"
                     /db_xref="MIM:600382"
ORIGIN      
        1 miedkgprva dyfvvagltd vskpleeeih fndachkvak pkepitdvsv iikslgeevp
       61 qdyicidvtp tglsadlnng slvgpqiylc yrrgrdkppl tdlgvlydwk erlkqgceii
      121 qstpygrpan isgstssqri yityrrasen mtqntlavtd iciiipskge spphtfckvd
      181 knlnnsmwgs avylcykksv aktntvsyka glicrypqed yesfslpesv plfclpmgat
      241 iecwpsnsky plpvfstfvl tgasaekvyg aaiqfyepys eenltekqrl llgltsadgk
      301 sdssktihtn kcicllshwp ffdafrkflt flyrysisgp hvlpiekhis hfmhkvpfps
      361 pqrprilvql sphdnlilsq pvssplplsg gkfstllqnl gpenavtllv favtehkili
      421 hslrpsvlts vtealvsmif pfhwpcpyvp lcplaladvl sapcpfivgi dsryfdlydp
      481 ppdvscvdvd tntisqigdk knvawkilpk kpcknlmntl nnlhqqlakl qqrprddglm
      541 dlaindydfn sgkrlhmidl eiqeaflffm asilkgyrsy lrpitqapse tatdaaslfa
      601 lqaflrsrdr shqkfynmmt ktqmfirfie ecsfvsdkda slaffddcvd kvdmdksgev
      661 rlieldesfk sehtvfvtpp eiphlpngee pplqysyngf pvlrnnlfer pegflqakkn
      721 klpskssspn splpmfrrtk qeiksahkia kryssipqmw srcllrhcyg lwficlpayv
      781 kvchskvral ktaydvlkkm qskkmdppde vcyrilmqlc gqydqpvlav rvlfemqkag
      841 idpnaitygy ynkavlestw psrsrsgyfl wtkvrnvvlg vtqfkralkk hahlsqttls
      901 ggqsdlgyns lskdevrrgd tstediqeek dkkgsdcssl sesestkgsa dclpklsyqn
      961 sssivrltgt snnsagkisg esmestpell lissledtne trniqsrcfr krhksdnetn
     1021 lqqqvvwgnr nrnlsggvlm gfmlnrinqe atpgdivekl gadakilsnv iskstrpntl
     1081 digkpplrsk rdslekessd ddtpfdgsny ladkvdspvi fdledldset dvskagcvat
     1141 qnpkriqrmn ssfsvkpfek tdvatgfdpl sllvaeteqq qkeeeeeded dsksistpsa
     1201 rrdlaeeivm ymnnmssplt srtpsidlqr acddklnkks pplvkacrrs slppnspkpv
     1261 rltksksytk seekprdrlw sspafsptcp freesqdtlt hsspsfnldt llvpkldvlr
     1321 nsmftagkgv aekaskwysr ftmyttsskd qssdrtslss vgaqdsests ltdedvchel
     1381 egpissqets atsgtkridl srislessas legslskfal pgksevtssf nasntnifqn
     1441 yamevlissc srcrtcdclv hdeeimagwt addsnlnttc pfcgniflpf lnieirdlrr
     1501 pgryflkssp stenmhfpss issqtrqsci stsasgldts alsvqgnfdl nsksklqenf
     1561 ctrsiqipan rsktamskcp ifpmarsist sgpldkedtg rqklistgsl patlqgatds
     1621 lglewhlpsp dpvtvpylsp lvvwkelesl lenegdhait vadfvdhhpi vfwnlvwyfr
     1681 rldlpsnlpg lilssehcnk yskiprhcms edskyvliqm lwdnmklhqd pgqplyilwn
     1741 ahsqsrtllf etqkypmvhl lqksdnsfnq ellksmvksi kmndvygpms qiletlnkcp
     1801 hfkrqrslyr eilflslval grenididaf dkeykmaydr ltpsqvksth ncdrppstgv
     1861 mecrktfgep yl
//
LOCUS       XP_047288057            1872 aa            linear   PRI 05-AUG-2025
DEFINITION  C-myc promoter-binding protein isoform X5 [Homo sapiens].
ACCESSION   XP_047288057
VERSION     XP_047288057.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432101.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1872
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1872
                     /product="C-myc promoter-binding protein isoform X5"
                     /calculated_mol_wt=210176
     Region          194..276
                     /region_name="uDENN"
                     /note="Domain always found upstream of DENN domain, found
                     in a variety of signalling proteins; smart00800"
                     /db_xref="CDD:214824"
     Region          308..492
                     /region_name="DENN"
                     /note="DENN (AEX-3) domain; pfam02141"
                     /db_xref="CDD:460461"
     Region          559..632
                     /region_name="dDENN"
                     /note="Domain always found downstream of DENN domain,
                     found in a variety of signalling proteins; smart00801"
                     /db_xref="CDD:129037"
     Region          808..848
                     /region_name="PPR_2"
                     /note="PPR repeat family; pfam13041"
                     /db_xref="CDD:463778"
     Region          810..839
                     /region_name="PPR repeat"
                     /note="PPR repeat [structural motif]"
                     /db_xref="CDD:276811"
     CDS             1..1872
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /coded_by="XM_047432101.1:469..6087"
                     /db_xref="GeneID:10260"
                     /db_xref="HGNC:HGNC:24321"
                     /db_xref="MIM:600382"
ORIGIN      
        1 miedkgprva dyfvvagltd vskpleeeih fndachkvak pkepitdvsv iikslgeevp
       61 qdyicidvtp tglsadlnng slvgpqiylc yrrgrdkppl tdlgvlydwk erlkqgceii
      121 qstpygrpan isgstssqri yityrrasen mtqntlavtd iciiipskge spphtfckvd
      181 knlnnsmwgs avylcykksv aktntvsyka glicrypqed yesfslpesv plfclpmgat
      241 iecwpsnsky plpvfstfvl tgasaekvyg aaiqfyepys eenltekqrl llgltsadgk
      301 sdssktihtn kcicllshwp ffdafrkflt flyrysisgp hvlpiekhis hfmhkvpfps
      361 pqrprilvql sphdnlilsq pvssplplsg gkfstllqnl gpenavtllv favtehkili
      421 hslrpsvlts vtealvsmif pfhwpcpyvp lcplaladvl sapcpfivgi dsryfdlydp
      481 ppdvscvdvd tntisqigdk knvawkilpk kpcknlmntl nnlhqqlakl qqrprddglm
      541 dlaindydfn sgkrlhmidl eiqeaflffm asilkgyrsy lrpitqapse tatdaaslfa
      601 lqaflrsrdr shqkfynmmt ktqmfirfie ecsfvsdkda slaffddcvd kvdmdksgev
      661 rlieldesfk sehtvfvtpp eiphlpngee pplqysyngf pvlrnnlfer pegflqakkn
      721 klpskssspn splpmfrrtk qeiksahkia kryssipqmw srcllrhcyg lwficlpayv
      781 kvchskvral ktaydvlkkm qskkmdppde vcyrilmqlc gqydqpvlav rvlfemqkag
      841 idpnaitygy ynkavlestw psrsrsgyfl wtkvrnvvlg vtqfkralkk hahlsqttls
      901 ggqsdlgyns lskdevrrgd tstediqeek dkkgsdcssl sesestkgsa dclpklsyqn
      961 sssivrltgt snnsagkisg esmestpell lissledtne trniqsrcfr krhksdnetn
     1021 lqqqvvwgnr nrnlsggvlm gfmlnrinqe atpgdivekl gadakilsnv iskstrpntl
     1081 digkpplrsk rdslekessd ddtpfdgsny ladkvdspvi fdledldset dvskagcvat
     1141 qnpkriqrmn ssfsvkpfek tdvatgfdpl sllvaeteqq qkeeeeeded dsksistpsa
     1201 rrdlaeeivm ymnnmssplt srtpsidlqr acddklnkks pplvkacrrs slppnspkpv
     1261 rltksksytk seekprdrlw sspafsptcp freesqdtlt hsspsfnldt llvpkldvlr
     1321 nsmftagkgv aekaskwysr ftmyttsskd qssdrtslss vgaqdsests ltdedvchel
     1381 egpissqets atsgtkridl srislessas legslskfal pgksevtssf nasntnifqn
     1441 yamevlissc srcrtcdclv hdeeimagwt addsnlnttc pfcgniflpf lnieirdlrr
     1501 pgryflkssp stenmhfpss issqtrqsci stsasgldts alsvqgnfdl nsksklqenf
     1561 ctrsiqipan rsktamskcp ifpmarsist sgpldkedtg rqklistgsl patlqgatds
     1621 lglewhlpsp dpvtvpylsp lvvwkelesl lenegdhait vadfvdhhpi vfwnlvwyfr
     1681 rldlpsnlpg lilssehcnk yskiprhcms edskyvliqm lwdnmklhqd pgqplyilwn
     1741 ahsqsrtllf etqkypmvhl lqksdnsfnq ellksmvksi kmndvygpms qiletlnkcp
     1801 hfkrqrslyr eilflslval grenididaf dkeykmaydr ltpsqvksth ncdrppstgv
     1861 mecrktfgep yl
//
LOCUS       XP_047288058            1863 aa            linear   PRI 05-AUG-2025
DEFINITION  C-myc promoter-binding protein isoform X6 [Homo sapiens].
ACCESSION   XP_047288058
VERSION     XP_047288058.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432102.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1863
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1863
                     /product="C-myc promoter-binding protein isoform X6"
                     /calculated_mol_wt=209114
     Region          194..276
                     /region_name="uDENN"
                     /note="Domain always found upstream of DENN domain, found
                     in a variety of signalling proteins; smart00800"
                     /db_xref="CDD:214824"
     Region          308..492
                     /region_name="DENN"
                     /note="DENN (AEX-3) domain; pfam02141"
                     /db_xref="CDD:460461"
     Region          559..632
                     /region_name="dDENN"
                     /note="Domain always found downstream of DENN domain,
                     found in a variety of signalling proteins; smart00801"
                     /db_xref="CDD:129037"
     Region          808..848
                     /region_name="PPR_2"
                     /note="PPR repeat family; pfam13041"
                     /db_xref="CDD:463778"
     Region          810..839
                     /region_name="PPR repeat"
                     /note="PPR repeat [structural motif]"
                     /db_xref="CDD:276811"
     CDS             1..1863
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /coded_by="XM_047432102.1:255..5846"
                     /db_xref="GeneID:10260"
                     /db_xref="HGNC:HGNC:24321"
                     /db_xref="MIM:600382"
ORIGIN      
        1 miedkgprva dyfvvagltd vskpleeeih fndachkvak pkepitdvsv iikslgeevp
       61 qdyicidvtp tglsadlnng slvgpqiylc yrrgrdkppl tdlgvlydwk erlkqgceii
      121 qstpygrpan isgstssqri yityrrasen mtqntlavtd iciiipskge spphtfckvd
      181 knlnnsmwgs avylcykksv aktntvsyka glicrypqed yesfslpesv plfclpmgat
      241 iecwpsnsky plpvfstfvl tgasaekvyg aaiqfyepys eenltekqrl llgltsadgk
      301 sdssktihtn kcicllshwp ffdafrkflt flyrysisgp hvlpiekhis hfmhkvpfps
      361 pqrprilvql sphdnlilsq pvssplplsg gkfstllqnl gpenavtllv favtehkili
      421 hslrpsvlts vtealvsmif pfhwpcpyvp lcplaladvl sapcpfivgi dsryfdlydp
      481 ppdvscvdvd tntisqigdk knvawkilpk kpcknlmntl nnlhqqlakl qqrprddglm
      541 dlaindydfn sgkrlhmidl eiqeaflffm asilkgyrsy lrpitqapse tatdaaslfa
      601 lqaflrsrdr shqkfynmmt ktqmfirfie ecsfvsdkda slaffddcvd kvdmdksgev
      661 rlieldesfk sehtvfvtpp eiphlpngee pplqysyngf pvlrnnlfer pegflqakkn
      721 klpskssspn splpmfrrtk qeiksahkia kryssipqmw srcllrhcyg lwficlpayv
      781 kvchskvral ktaydvlkkm qskkmdppde vcyrilmqlc gqydqpvlav rvlfemqkag
      841 idpnaitygy ynkavlestw psrsrsgyfl wtkvrnvvlg vtqfkralkk hahlsqttls
      901 ggqsdlgyns lskdevrrgd tstediqeek dkkgsdcssl sesestkgsa dclpklsyqn
      961 sssivrltgt snnsagkisg esmestpell lissledtne trniqsrcfr krhksdnetn
     1021 lqqqvvwgnr nrnlsggvlm gfmlnrinqe atpgdivekl gadakilsnv iskstrpntl
     1081 digkpplrsk rdslekessd ddtpfdgsny ladkvdspvi fdledldset dvskagcvat
     1141 qnpkriqrmn ssfsvkpfek tdvatgfdpl sllvaeteqq qkeeeeeded dsksistpsa
     1201 rrdlaeeivm ymnnmssplt srtpsidlqr acddklnkks pplvkacrrs slppnspkpv
     1261 rltksksytk seekprdrlw sspafsptcp freesqdtlt hsspsfnldt llvpkldvlr
     1321 nsmftagkgv aekaskwysr ftmyttsskd qssdrtslss vgaqdsests ltdedvchel
     1381 egpissqets atsgtkridl srislessas legslskfal pgksevtssf nasntnifqn
     1441 yamevlissc srcrtcdclv hdeeimagwt addsnlnttc pfcgniflpf lnieirdlrr
     1501 pgryflkssp stenmhfpss issqtrqsci stsasgldts alsvqgnfdl nsksklqenf
     1561 ctrsiqipan rsktamskcp ifpmarsist sgpldkedtg rqklistgsl patlqgatds
     1621 lglewhlpsp dpvtvpylsp lvvwkelesl lenegdhait vadfvdhhpi vfwnlvwyfr
     1681 rldlpsnlpg lilssehcnk yskiprhcms edskyvliqm lwdnmklhqd pgqplyilwn
     1741 ahtqkypmvh llqksdnsfn qellksmvks ikmndvygpm sqiletlnkc phfkrqrsly
     1801 reilflslva lgrenidida fdkeykmayd rltpsqvkst hncdrppstg vmecrktfge
     1861 pyl
//
LOCUS       XP_047288059            1863 aa            linear   PRI 05-AUG-2025
DEFINITION  C-myc promoter-binding protein isoform X6 [Homo sapiens].
ACCESSION   XP_047288059
VERSION     XP_047288059.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432103.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1863
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1863
                     /product="C-myc promoter-binding protein isoform X6"
                     /calculated_mol_wt=209114
     Region          194..276
                     /region_name="uDENN"
                     /note="Domain always found upstream of DENN domain, found
                     in a variety of signalling proteins; smart00800"
                     /db_xref="CDD:214824"
     Region          308..492
                     /region_name="DENN"
                     /note="DENN (AEX-3) domain; pfam02141"
                     /db_xref="CDD:460461"
     Region          559..632
                     /region_name="dDENN"
                     /note="Domain always found downstream of DENN domain,
                     found in a variety of signalling proteins; smart00801"
                     /db_xref="CDD:129037"
     Region          808..848
                     /region_name="PPR_2"
                     /note="PPR repeat family; pfam13041"
                     /db_xref="CDD:463778"
     Region          810..839
                     /region_name="PPR repeat"
                     /note="PPR repeat [structural motif]"
                     /db_xref="CDD:276811"
     CDS             1..1863
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /coded_by="XM_047432103.1:469..6060"
                     /db_xref="GeneID:10260"
                     /db_xref="HGNC:HGNC:24321"
                     /db_xref="MIM:600382"
ORIGIN      
        1 miedkgprva dyfvvagltd vskpleeeih fndachkvak pkepitdvsv iikslgeevp
       61 qdyicidvtp tglsadlnng slvgpqiylc yrrgrdkppl tdlgvlydwk erlkqgceii
      121 qstpygrpan isgstssqri yityrrasen mtqntlavtd iciiipskge spphtfckvd
      181 knlnnsmwgs avylcykksv aktntvsyka glicrypqed yesfslpesv plfclpmgat
      241 iecwpsnsky plpvfstfvl tgasaekvyg aaiqfyepys eenltekqrl llgltsadgk
      301 sdssktihtn kcicllshwp ffdafrkflt flyrysisgp hvlpiekhis hfmhkvpfps
      361 pqrprilvql sphdnlilsq pvssplplsg gkfstllqnl gpenavtllv favtehkili
      421 hslrpsvlts vtealvsmif pfhwpcpyvp lcplaladvl sapcpfivgi dsryfdlydp
      481 ppdvscvdvd tntisqigdk knvawkilpk kpcknlmntl nnlhqqlakl qqrprddglm
      541 dlaindydfn sgkrlhmidl eiqeaflffm asilkgyrsy lrpitqapse tatdaaslfa
      601 lqaflrsrdr shqkfynmmt ktqmfirfie ecsfvsdkda slaffddcvd kvdmdksgev
      661 rlieldesfk sehtvfvtpp eiphlpngee pplqysyngf pvlrnnlfer pegflqakkn
      721 klpskssspn splpmfrrtk qeiksahkia kryssipqmw srcllrhcyg lwficlpayv
      781 kvchskvral ktaydvlkkm qskkmdppde vcyrilmqlc gqydqpvlav rvlfemqkag
      841 idpnaitygy ynkavlestw psrsrsgyfl wtkvrnvvlg vtqfkralkk hahlsqttls
      901 ggqsdlgyns lskdevrrgd tstediqeek dkkgsdcssl sesestkgsa dclpklsyqn
      961 sssivrltgt snnsagkisg esmestpell lissledtne trniqsrcfr krhksdnetn
     1021 lqqqvvwgnr nrnlsggvlm gfmlnrinqe atpgdivekl gadakilsnv iskstrpntl
     1081 digkpplrsk rdslekessd ddtpfdgsny ladkvdspvi fdledldset dvskagcvat
     1141 qnpkriqrmn ssfsvkpfek tdvatgfdpl sllvaeteqq qkeeeeeded dsksistpsa
     1201 rrdlaeeivm ymnnmssplt srtpsidlqr acddklnkks pplvkacrrs slppnspkpv
     1261 rltksksytk seekprdrlw sspafsptcp freesqdtlt hsspsfnldt llvpkldvlr
     1321 nsmftagkgv aekaskwysr ftmyttsskd qssdrtslss vgaqdsests ltdedvchel
     1381 egpissqets atsgtkridl srislessas legslskfal pgksevtssf nasntnifqn
     1441 yamevlissc srcrtcdclv hdeeimagwt addsnlnttc pfcgniflpf lnieirdlrr
     1501 pgryflkssp stenmhfpss issqtrqsci stsasgldts alsvqgnfdl nsksklqenf
     1561 ctrsiqipan rsktamskcp ifpmarsist sgpldkedtg rqklistgsl patlqgatds
     1621 lglewhlpsp dpvtvpylsp lvvwkelesl lenegdhait vadfvdhhpi vfwnlvwyfr
     1681 rldlpsnlpg lilssehcnk yskiprhcms edskyvliqm lwdnmklhqd pgqplyilwn
     1741 ahtqkypmvh llqksdnsfn qellksmvks ikmndvygpm sqiletlnkc phfkrqrsly
     1801 reilflslva lgrenidida fdkeykmayd rltpsqvkst hncdrppstg vmecrktfge
     1861 pyl
//
LOCUS       XP_047288060            1863 aa            linear   PRI 05-AUG-2025
DEFINITION  C-myc promoter-binding protein isoform X6 [Homo sapiens].
ACCESSION   XP_047288060
VERSION     XP_047288060.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432104.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1863
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1863
                     /product="C-myc promoter-binding protein isoform X6"
                     /calculated_mol_wt=209114
     Region          194..276
                     /region_name="uDENN"
                     /note="Domain always found upstream of DENN domain, found
                     in a variety of signalling proteins; smart00800"
                     /db_xref="CDD:214824"
     Region          308..492
                     /region_name="DENN"
                     /note="DENN (AEX-3) domain; pfam02141"
                     /db_xref="CDD:460461"
     Region          559..632
                     /region_name="dDENN"
                     /note="Domain always found downstream of DENN domain,
                     found in a variety of signalling proteins; smart00801"
                     /db_xref="CDD:129037"
     Region          808..848
                     /region_name="PPR_2"
                     /note="PPR repeat family; pfam13041"
                     /db_xref="CDD:463778"
     Region          810..839
                     /region_name="PPR repeat"
                     /note="PPR repeat [structural motif]"
                     /db_xref="CDD:276811"
     CDS             1..1863
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /coded_by="XM_047432104.1:338..5929"
                     /db_xref="GeneID:10260"
                     /db_xref="HGNC:HGNC:24321"
                     /db_xref="MIM:600382"
ORIGIN      
        1 miedkgprva dyfvvagltd vskpleeeih fndachkvak pkepitdvsv iikslgeevp
       61 qdyicidvtp tglsadlnng slvgpqiylc yrrgrdkppl tdlgvlydwk erlkqgceii
      121 qstpygrpan isgstssqri yityrrasen mtqntlavtd iciiipskge spphtfckvd
      181 knlnnsmwgs avylcykksv aktntvsyka glicrypqed yesfslpesv plfclpmgat
      241 iecwpsnsky plpvfstfvl tgasaekvyg aaiqfyepys eenltekqrl llgltsadgk
      301 sdssktihtn kcicllshwp ffdafrkflt flyrysisgp hvlpiekhis hfmhkvpfps
      361 pqrprilvql sphdnlilsq pvssplplsg gkfstllqnl gpenavtllv favtehkili
      421 hslrpsvlts vtealvsmif pfhwpcpyvp lcplaladvl sapcpfivgi dsryfdlydp
      481 ppdvscvdvd tntisqigdk knvawkilpk kpcknlmntl nnlhqqlakl qqrprddglm
      541 dlaindydfn sgkrlhmidl eiqeaflffm asilkgyrsy lrpitqapse tatdaaslfa
      601 lqaflrsrdr shqkfynmmt ktqmfirfie ecsfvsdkda slaffddcvd kvdmdksgev
      661 rlieldesfk sehtvfvtpp eiphlpngee pplqysyngf pvlrnnlfer pegflqakkn
      721 klpskssspn splpmfrrtk qeiksahkia kryssipqmw srcllrhcyg lwficlpayv
      781 kvchskvral ktaydvlkkm qskkmdppde vcyrilmqlc gqydqpvlav rvlfemqkag
      841 idpnaitygy ynkavlestw psrsrsgyfl wtkvrnvvlg vtqfkralkk hahlsqttls
      901 ggqsdlgyns lskdevrrgd tstediqeek dkkgsdcssl sesestkgsa dclpklsyqn
      961 sssivrltgt snnsagkisg esmestpell lissledtne trniqsrcfr krhksdnetn
     1021 lqqqvvwgnr nrnlsggvlm gfmlnrinqe atpgdivekl gadakilsnv iskstrpntl
     1081 digkpplrsk rdslekessd ddtpfdgsny ladkvdspvi fdledldset dvskagcvat
     1141 qnpkriqrmn ssfsvkpfek tdvatgfdpl sllvaeteqq qkeeeeeded dsksistpsa
     1201 rrdlaeeivm ymnnmssplt srtpsidlqr acddklnkks pplvkacrrs slppnspkpv
     1261 rltksksytk seekprdrlw sspafsptcp freesqdtlt hsspsfnldt llvpkldvlr
     1321 nsmftagkgv aekaskwysr ftmyttsskd qssdrtslss vgaqdsests ltdedvchel
     1381 egpissqets atsgtkridl srislessas legslskfal pgksevtssf nasntnifqn
     1441 yamevlissc srcrtcdclv hdeeimagwt addsnlnttc pfcgniflpf lnieirdlrr
     1501 pgryflkssp stenmhfpss issqtrqsci stsasgldts alsvqgnfdl nsksklqenf
     1561 ctrsiqipan rsktamskcp ifpmarsist sgpldkedtg rqklistgsl patlqgatds
     1621 lglewhlpsp dpvtvpylsp lvvwkelesl lenegdhait vadfvdhhpi vfwnlvwyfr
     1681 rldlpsnlpg lilssehcnk yskiprhcms edskyvliqm lwdnmklhqd pgqplyilwn
     1741 ahtqkypmvh llqksdnsfn qellksmvks ikmndvygpm sqiletlnkc phfkrqrsly
     1801 reilflslva lgrenidida fdkeykmayd rltpsqvkst hncdrppstg vmecrktfge
     1861 pyl
//
LOCUS       XP_047288061            1400 aa            linear   PRI 05-AUG-2025
DEFINITION  C-myc promoter-binding protein isoform X7 [Homo sapiens].
ACCESSION   XP_047288061
VERSION     XP_047288061.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432105.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1400
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1400
                     /product="C-myc promoter-binding protein isoform X7"
                     /calculated_mol_wt=157255
     Region          43..116
                     /region_name="dDENN"
                     /note="Domain always found downstream of DENN domain,
                     found in a variety of signalling proteins; smart00801"
                     /db_xref="CDD:129037"
     Region          292..332
                     /region_name="PPR_2"
                     /note="PPR repeat family; pfam13041"
                     /db_xref="CDD:463778"
     Region          294..323
                     /region_name="PPR repeat"
                     /note="PPR repeat [structural motif]"
                     /db_xref="CDD:276811"
     CDS             1..1400
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /coded_by="XM_047432105.1:275..4477"
                     /db_xref="GeneID:10260"
                     /db_xref="HGNC:HGNC:24321"
                     /db_xref="MIM:600382"
ORIGIN      
        1 mntlnnlhqq laklqqrprd dglmdlaind ydfnsgkrlh midleiqeaf lffmasilkg
       61 yrsylrpitq apsetatdaa slfalqaflr srdrshqkfy nmmtktqmfi rfieecsfvs
      121 dkdaslaffd dcvdkvdmdk sgevrlield esfksehtvf vtppeiphlp ngeepplqys
      181 yngfpvlrnn lferpegflq akknklpsks sspnsplpmf rrtkqeiksa hkiakryssi
      241 pqmwsrcllr hcyglwficl payvkvchsk vralktaydv lkkmqskkmd ppdevcyril
      301 mqlcgqydqp vlavrvlfem qkagidpnai tygyynkavl estwpsrsrs gyflwtkvrn
      361 vvlgvtqfkr alkkhahlsq ttlsadgsdl davshgsmds ghgthtveqa pfntglikvy
      421 atddrsstgg qsdlgynsls kdevrrgdts tediqeekdk kgsdcsslse sestkgsadc
      481 lpklsyqnss sivrltgtsn nsagkisges mestpellli ssledtnetr niqsrcfrkr
      541 hksdnetnlq qqvvwgnrnr nlsggvlmgf mlnrinqeat pgdiveklga dakilsnvis
      601 kstrpntldi gkpplrskrd slekessddd tpfdgsnyla dkvdspvifd ledldsetdv
      661 skagcvatqn pkriqrmnss fsvkpfektd vatgfdplsl lvaeteqqqk eeeeededds
      721 ksistpsarr dlaeeivmym nnmsspltsr tpsidlqrac ddklnkkspp lvkacrrssl
      781 ppnspkpvrl tksksytkse ekprdrlwss pafsptcpfr eesqdtlths spsfnldtll
      841 vpkldvlrns mftagkgvae kaskwysrft myttsskdqs sdrtslssvg aqdsestslt
      901 dedvcheleg pissqetsat sgtkridlsr islessasle gslskfalpg ksevtssfna
      961 sntnifqnya mevlisscsr crtcdclvhd eeimagwtad dsnlnttcpf cgniflpfln
     1021 ieirdlrrpg ryflksspst enmhfpssis sqtrqscist sasgldtsal svqgnfdlns
     1081 ksklqenfct rsiqipanrs ktamskcpif pmarsistsg pldkedtgrq klistgslpa
     1141 tlqgatdslg lewhlpspdp vtvpylsplv vwkeleslle negdhaitva dfvdhhpivf
     1201 wnlvwyfrrl dlpsnlpgli lssehcnkys kiprhcmsed skyvliqmlw dnmklhqdpg
     1261 qplyilwnah sqsrtllfet qkypmvhllq ksdnsfnqel lksmvksikm ndvygpmsqi
     1321 letlnkcphf krqrslyrei lflslvalgr enididafdk eykmaydrlt psqvksthnc
     1381 drppstgvme crktfgepyl
//
LOCUS       XP_011519458            1393 aa            linear   PRI 05-AUG-2025
DEFINITION  C-myc promoter-binding protein isoform X8 [Homo sapiens].
ACCESSION   XP_011519458
VERSION     XP_011519458.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521156.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1393
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1393
                     /product="C-myc promoter-binding protein isoform X8"
                     /calculated_mol_wt=156059
     Region          194..276
                     /region_name="uDENN"
                     /note="Domain always found upstream of DENN domain, found
                     in a variety of signalling proteins; smart00800"
                     /db_xref="CDD:214824"
     Region          308..492
                     /region_name="DENN"
                     /note="DENN (AEX-3) domain; pfam02141"
                     /db_xref="CDD:460461"
     Region          559..632
                     /region_name="dDENN"
                     /note="Domain always found downstream of DENN domain,
                     found in a variety of signalling proteins; smart00801"
                     /db_xref="CDD:129037"
     Region          808..848
                     /region_name="PPR_2"
                     /note="PPR repeat family; pfam13041"
                     /db_xref="CDD:463778"
     Region          810..839
                     /region_name="PPR repeat"
                     /note="PPR repeat [structural motif]"
                     /db_xref="CDD:276811"
     CDS             1..1393
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /coded_by="XM_011521156.4:386..4567"
                     /db_xref="GeneID:10260"
                     /db_xref="HGNC:HGNC:24321"
                     /db_xref="MIM:600382"
ORIGIN      
        1 miedkgprva dyfvvagltd vskpleeeih fndachkvak pkepitdvsv iikslgeevp
       61 qdyicidvtp tglsadlnng slvgpqiylc yrrgrdkppl tdlgvlydwk erlkqgceii
      121 qstpygrpan isgstssqri yityrrasen mtqntlavtd iciiipskge spphtfckvd
      181 knlnnsmwgs avylcykksv aktntvsyka glicrypqed yesfslpesv plfclpmgat
      241 iecwpsnsky plpvfstfvl tgasaekvyg aaiqfyepys eenltekqrl llgltsadgk
      301 sdssktihtn kcicllshwp ffdafrkflt flyrysisgp hvlpiekhis hfmhkvpfps
      361 pqrprilvql sphdnlilsq pvssplplsg gkfstllqnl gpenavtllv favtehkili
      421 hslrpsvlts vtealvsmif pfhwpcpyvp lcplaladvl sapcpfivgi dsryfdlydp
      481 ppdvscvdvd tntisqigdk knvawkilpk kpcknlmntl nnlhqqlakl qqrprddglm
      541 dlaindydfn sgkrlhmidl eiqeaflffm asilkgyrsy lrpitqapse tatdaaslfa
      601 lqaflrsrdr shqkfynmmt ktqmfirfie ecsfvsdkda slaffddcvd kvdmdksgev
      661 rlieldesfk sehtvfvtpp eiphlpngee pplqysyngf pvlrnnlfer pegflqakkn
      721 klpskssspn splpmfrrtk qeiksahkia kryssipqmw srcllrhcyg lwficlpayv
      781 kvchskvral ktaydvlkkm qskkmdppde vcyrilmqlc gqydqpvlav rvlfemqkag
      841 idpnaitygy ynkavlestw psrsrsgyfl wtkvrnvvlg vtqfkralkk hahlsqttls
      901 adgsdldavs hgsmdsghgt htveqapfnt glikvyatdd rsstggqsdl gynslskdev
      961 rrgdtstedi qeekdkkgsd csslsesest kgsadclpkl syqnsssivr ltgtsnnsag
     1021 kisgesmest pelllissle dtnetrniqs rcfrkrhksd netnlqqqvv wgnrnrnlsg
     1081 gvlmgfmlnr inqeatpgdi veklgadaki lsnviskstr pntldigkpp lrskrdslek
     1141 essdddtpfd gsnyladkvd spvifdledl dsetdvskag cvatqnpkri qrmnssfsvk
     1201 pfektdvatg fdplsllvae teqqqkeeee ededdsksis tpsarrdlae eivmymnnms
     1261 spltsrtpsi dlqracddkl nkkspplvka crrsslppns pkpvrltksk sytkseekpr
     1321 drlwsspafs ptcpfreesq dtlthsspsf nldtllvpkl dvlrnsmfta gkgvaekask
     1381 wysrftmytt ssk
//
LOCUS       XP_047288062            1349 aa            linear   PRI 05-AUG-2025
DEFINITION  C-myc promoter-binding protein isoform X9 [Homo sapiens].
ACCESSION   XP_047288062
VERSION     XP_047288062.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432106.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1349
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1349
                     /product="C-myc promoter-binding protein isoform X9"
                     /calculated_mol_wt=151529
     Region          194..276
                     /region_name="uDENN"
                     /note="Domain always found upstream of DENN domain, found
                     in a variety of signalling proteins; smart00800"
                     /db_xref="CDD:214824"
     Region          308..492
                     /region_name="DENN"
                     /note="DENN (AEX-3) domain; pfam02141"
                     /db_xref="CDD:460461"
     Region          559..632
                     /region_name="dDENN"
                     /note="Domain always found downstream of DENN domain,
                     found in a variety of signalling proteins; smart00801"
                     /db_xref="CDD:129037"
     Region          808..848
                     /region_name="PPR_2"
                     /note="PPR repeat family; pfam13041"
                     /db_xref="CDD:463778"
     Region          810..839
                     /region_name="PPR repeat"
                     /note="PPR repeat [structural motif]"
                     /db_xref="CDD:276811"
     CDS             1..1349
                     /gene="DENND4A"
                     /gene_synonym="IRLB; MYCPBP"
                     /coded_by="XM_047432106.1:386..4435"
                     /db_xref="GeneID:10260"
                     /db_xref="HGNC:HGNC:24321"
                     /db_xref="MIM:600382"
ORIGIN      
        1 miedkgprva dyfvvagltd vskpleeeih fndachkvak pkepitdvsv iikslgeevp
       61 qdyicidvtp tglsadlnng slvgpqiylc yrrgrdkppl tdlgvlydwk erlkqgceii
      121 qstpygrpan isgstssqri yityrrasen mtqntlavtd iciiipskge spphtfckvd
      181 knlnnsmwgs avylcykksv aktntvsyka glicrypqed yesfslpesv plfclpmgat
      241 iecwpsnsky plpvfstfvl tgasaekvyg aaiqfyepys eenltekqrl llgltsadgk
      301 sdssktihtn kcicllshwp ffdafrkflt flyrysisgp hvlpiekhis hfmhkvpfps
      361 pqrprilvql sphdnlilsq pvssplplsg gkfstllqnl gpenavtllv favtehkili
      421 hslrpsvlts vtealvsmif pfhwpcpyvp lcplaladvl sapcpfivgi dsryfdlydp
      481 ppdvscvdvd tntisqigdk knvawkilpk kpcknlmntl nnlhqqlakl qqrprddglm
      541 dlaindydfn sgkrlhmidl eiqeaflffm asilkgyrsy lrpitqapse tatdaaslfa
      601 lqaflrsrdr shqkfynmmt ktqmfirfie ecsfvsdkda slaffddcvd kvdmdksgev
      661 rlieldesfk sehtvfvtpp eiphlpngee pplqysyngf pvlrnnlfer pegflqakkn
      721 klpskssspn splpmfrrtk qeiksahkia kryssipqmw srcllrhcyg lwficlpayv
      781 kvchskvral ktaydvlkkm qskkmdppde vcyrilmqlc gqydqpvlav rvlfemqkag
      841 idpnaitygy ynkavlestw psrsrsgyfl wtkvrnvvlg vtqfkralkk hahlsqttls
      901 ggqsdlgyns lskdevrrgd tstediqeek dkkgsdcssl sesestkgsa dclpklsyqn
      961 sssivrltgt snnsagkisg esmestpell lissledtne trniqsrcfr krhksdnetn
     1021 lqqqvvwgnr nrnlsggvlm gfmlnrinqe atpgdivekl gadakilsnv iskstrpntl
     1081 digkpplrsk rdslekessd ddtpfdgsny ladkvdspvi fdledldset dvskagcvat
     1141 qnpkriqrmn ssfsvkpfek tdvatgfdpl sllvaeteqq qkeeeeeded dsksistpsa
     1201 rrdlaeeivm ymnnmssplt srtpsidlqr acddklnkks pplvkacrrs slppnspkpv
     1261 rltksksytk seekprdrlw sspafsptcp freesqdtlt hsspsfnldt llvpkldvlr
     1321 nsmftagkgv aekaskwysr ftmyttssk
//
LOCUS       XP_016878267             674 aa            linear   PRI 05-AUG-2025
DEFINITION  golgin subfamily A member 6-like protein 26 isoform X1 [Homo
            sapiens].
ACCESSION   XP_016878267
VERSION     XP_016878267.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022778.2
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 2% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..674
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..674
                     /product="golgin subfamily A member 6-like protein 26
                     isoform X1"
                     /calculated_mol_wt=83353
     Region          <161..646
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     CDS             1..674
                     /gene="GOLGA6L26"
                     /coded_by="XM_017022778.2:56..2080"
                     /db_xref="GeneID:102723623"
                     /db_xref="HGNC:HGNC:56306"
ORIGIN      
        1 mlmwpqphlp thphlpthph lpthpmmske trqsklaeak eqltdhhpqt npsvgtaasd
       61 tkkkkinngt npetttsggc hspedeqkas hqhqealrre leaqvhtiri ltcqktelqm
      121 alyysqhavk qlegeardli srlhdswkfa geleqalsav atqkkkadry ieeltkerda
      181 lslelyrnti tdeelkekna klqeklqlve sekseiqlnv kelkrklera klllpqqqlq
      241 aeadhlgkel qsvsaklqaq veenelwnrl nqqqeekmwr qeekiqewee kiqeqeekir
      301 eqeekireqe ekmrrqeemm wekeekmrrq eemmwekeek mrrleemmwe keekirelee
      361 kmheqekire qeekrqeeek ireqekrqeq eakmwrqeek ireqeekire qekkmwrqee
      421 kiheqekire eekrqeqeem wrqeekireq eeiwrqkekm heqekirkqe ekvwrqeekm
      481 hdqeekireq eekmwrqeek ireqeekire qeekireqee kireqeemmq eqeekmgeqe
      541 ekmqeqekmr rqeekireqe ekireqkeki reqeekiweq eekireqeem mqeqeekmwe
      601 qeekmceqee kmqeqeekmr rqeekmweqe vrlrqqeekm qehqvelksq eaesaaaarp
      661 lpgspaaehl eaai
//
LOCUS       XP_047288063             384 aa            linear   PRI 05-AUG-2025
DEFINITION  POTE ankyrin domain family member B3 isoform X1 [Homo sapiens].
ACCESSION   XP_047288063
VERSION     XP_047288063.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432107.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 5% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..384
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..384
                     /product="POTE ankyrin domain family member B3 isoform X1"
                     /calculated_mol_wt=42935
     Region          137..368
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Site            order(174,178..179,182..184,186..187,191,194,203,205,207,
                     211..212,215..217,219..220,224,227,236,238,240,244..245,
                     248..250,252..253,257,260,269)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          174..203
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          205..236
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          238..269
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          271..302
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          304..335
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     CDS             1..384
                     /gene="POTEB3"
                     /gene_synonym="POTE-15; POTEB"
                     /coded_by="XM_047432107.1:489..1643"
                     /db_xref="GeneID:102724631"
                     /db_xref="HGNC:HGNC:51240"
ORIGIN      
        1 mvaevcsmpa asavkkpfdl rskmgkwchh rfpccrgsgk snmgtsgdhd dsfmktlrsk
       61 mgkcchhcfp ccrgsgtsnv gtsgdhdnsf mktlrskmgk wcchcfpccr gsgksnvgtw
      121 gdyddsafme pryhvrredl dklhraawwg kvprkdlivm lrdtdmnkrd kqkrtalhla
      181 sangnsevvq llldrrcqln vldnkkrtal ikavqcqede cvlmllehga dgniqdeygn
      241 talhyaiyne dklmakalll ygadiesknk cgltplllgv heqkqqvvkf likkkanlna
      301 ldrygrtali lavccgsasi vnllleqnvd vssqdlsgqt areyavsshh hvicellsdy
      361 kekqmlkiss ensnpenvsr trnk
//
LOCUS       XP_011542098             376 aa            linear   PRI 05-AUG-2025
DEFINITION  POTE ankyrin domain family member B3 isoform X2 [Homo sapiens].
ACCESSION   XP_011542098
VERSION     XP_011542098.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011543796.3
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 5% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..376
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..376
                     /product="POTE ankyrin domain family member B3 isoform X2"
                     /calculated_mol_wt=41948
     Region          137..368
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Site            order(174,178..179,182..184,186..187,191,194,203,205,207,
                     211..212,215..217,219..220,224,227,236,238,240,244..245,
                     248..250,252..253,257,260,269)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          174..203
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          205..236
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          238..269
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          271..302
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          304..335
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     CDS             1..376
                     /gene="POTEB3"
                     /gene_synonym="POTE-15; POTEB"
                     /coded_by="XM_011543796.3:489..1619"
                     /db_xref="GeneID:102724631"
                     /db_xref="HGNC:HGNC:51240"
ORIGIN      
        1 mvaevcsmpa asavkkpfdl rskmgkwchh rfpccrgsgk snmgtsgdhd dsfmktlrsk
       61 mgkcchhcfp ccrgsgtsnv gtsgdhdnsf mktlrskmgk wcchcfpccr gsgksnvgtw
      121 gdyddsafme pryhvrredl dklhraawwg kvprkdlivm lrdtdmnkrd kqkrtalhla
      181 sangnsevvq llldrrcqln vldnkkrtal ikavqcqede cvlmllehga dgniqdeygn
      241 talhyaiyne dklmakalll ygadiesknk cgltplllgv heqkqqvvkf likkkanlna
      301 ldrygrtali lavccgsasi vnllleqnvd vssqdlsgqt areyavsshh hvicellsdy
      361 kekqmlkiss ensnpv
//
LOCUS       XP_011542099             376 aa            linear   PRI 05-AUG-2025
DEFINITION  POTE ankyrin domain family member B3 isoform X3 [Homo sapiens].
ACCESSION   XP_011542099
VERSION     XP_011542099.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011543797.3
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 5% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..376
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..376
                     /product="POTE ankyrin domain family member B3 isoform X3"
                     /calculated_mol_wt=41906
     Region          137..368
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Site            order(174,178..179,182..184,186..187,191,194,203,205,207,
                     211..212,215..217,219..220,224,227,236,238,240,244..245,
                     248..250,252..253,257,260,269)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          174..203
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          205..236
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          238..269
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          271..302
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          304..335
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     CDS             1..376
                     /gene="POTEB3"
                     /gene_synonym="POTE-15; POTEB"
                     /coded_by="XM_011543797.3:489..1619"
                     /db_xref="GeneID:102724631"
                     /db_xref="HGNC:HGNC:51240"
ORIGIN      
        1 mvaevcsmpa asavkkpfdl rskmgkwchh rfpccrgsgk snmgtsgdhd dsfmktlrsk
       61 mgkcchhcfp ccrgsgtsnv gtsgdhdnsf mktlrskmgk wcchcfpccr gsgksnvgtw
      121 gdyddsafme pryhvrredl dklhraawwg kvprkdlivm lrdtdmnkrd kqkrtalhla
      181 sangnsevvq llldrrcqln vldnkkrtal ikavqcqede cvlmllehga dgniqdeygn
      241 talhyaiyne dklmakalll ygadiesknk cgltplllgv heqkqqvvkf likkkanlna
      301 ldrygrtali lavccgsasi vnllleqnvd vssqdlsgqt areyavsshh hvicellsdy
      361 kekqmlkiss ensnpg
//
LOCUS       XP_047288064             347 aa            linear   PRI 05-AUG-2025
DEFINITION  high mobility group protein 20A isoform X1 [Homo sapiens].
ACCESSION   XP_047288064
VERSION     XP_047288064.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432108.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..347
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..347
                     /product="high mobility group protein 20A isoform X1"
                     /calculated_mol_wt=40013
     Region          <59..313
                     /region_name="DUF5401"
                     /note="Family of unknown function (DUF5401); pfam17380"
                     /db_xref="CDD:375164"
     Region          83..186
                     /region_name="HMG-box_HMG20A"
                     /note="high mobility group (HMG)-box found in high
                     mobility group protein 20A (HMG20A) and similar proteins;
                     cd22017"
                     /db_xref="CDD:438833"
     Site            order(104..105,107..111,114..115,122,134..135,138,
                     141..142,149,153,156,160,163)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:438833"
     CDS             1..347
                     /gene="HMG20A"
                     /gene_synonym="HMGX1; HMGXB1"
                     /coded_by="XM_047432108.1:122..1165"
                     /db_xref="GeneID:10363"
                     /db_xref="HGNC:HGNC:5001"
                     /db_xref="MIM:605534"
ORIGIN      
        1 menlmtsstl pplfadedgs kesndlattg lnhpevpyss gatsstnnpe fvedlsqgql
       61 lqsessnaae gneqrhedeq rskrggwskg rkrkkplrds napkspltgy vrfmnerreq
      121 lrakrpevpf peitrmlgne wsklppeekq ryldeadrdk erymkeleqy qkteaykvfs
      181 rktqdrqkgk shrqdaarqa thdheketev kersvfdipi fteeflnhsk areaelrqlr
      241 ksnmefeern aalqkhvesm rtaveklevd viqersrntv lqqhletlrq vltssfasmp
      301 lpgsgetptv dtidsymnrl hsiilanpqd nenfiatvre vvnrldr
//
LOCUS       XP_047288065             347 aa            linear   PRI 05-AUG-2025
DEFINITION  high mobility group protein 20A isoform X1 [Homo sapiens].
ACCESSION   XP_047288065
VERSION     XP_047288065.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432109.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..347
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..347
                     /product="high mobility group protein 20A isoform X1"
                     /calculated_mol_wt=40013
     Region          <59..313
                     /region_name="DUF5401"
                     /note="Family of unknown function (DUF5401); pfam17380"
                     /db_xref="CDD:375164"
     Region          83..186
                     /region_name="HMG-box_HMG20A"
                     /note="high mobility group (HMG)-box found in high
                     mobility group protein 20A (HMG20A) and similar proteins;
                     cd22017"
                     /db_xref="CDD:438833"
     Site            order(104..105,107..111,114..115,122,134..135,138,
                     141..142,149,153,156,160,163)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:438833"
     CDS             1..347
                     /gene="HMG20A"
                     /gene_synonym="HMGX1; HMGXB1"
                     /coded_by="XM_047432109.1:215..1258"
                     /db_xref="GeneID:10363"
                     /db_xref="HGNC:HGNC:5001"
                     /db_xref="MIM:605534"
ORIGIN      
        1 menlmtsstl pplfadedgs kesndlattg lnhpevpyss gatsstnnpe fvedlsqgql
       61 lqsessnaae gneqrhedeq rskrggwskg rkrkkplrds napkspltgy vrfmnerreq
      121 lrakrpevpf peitrmlgne wsklppeekq ryldeadrdk erymkeleqy qkteaykvfs
      181 rktqdrqkgk shrqdaarqa thdheketev kersvfdipi fteeflnhsk areaelrqlr
      241 ksnmefeern aalqkhvesm rtaveklevd viqersrntv lqqhletlrq vltssfasmp
      301 lpgsgetptv dtidsymnrl hsiilanpqd nenfiatvre vvnrldr
//
LOCUS       XP_011519460             347 aa            linear   PRI 05-AUG-2025
DEFINITION  high mobility group protein 20A isoform X1 [Homo sapiens].
ACCESSION   XP_011519460
VERSION     XP_011519460.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521158.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..347
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..347
                     /product="high mobility group protein 20A isoform X1"
                     /calculated_mol_wt=40013
     Region          <59..313
                     /region_name="DUF5401"
                     /note="Family of unknown function (DUF5401); pfam17380"
                     /db_xref="CDD:375164"
     Region          83..186
                     /region_name="HMG-box_HMG20A"
                     /note="high mobility group (HMG)-box found in high
                     mobility group protein 20A (HMG20A) and similar proteins;
                     cd22017"
                     /db_xref="CDD:438833"
     Site            order(104..105,107..111,114..115,122,134..135,138,
                     141..142,149,153,156,160,163)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:438833"
     CDS             1..347
                     /gene="HMG20A"
                     /gene_synonym="HMGX1; HMGXB1"
                     /coded_by="XM_011521158.4:122..1165"
                     /db_xref="GeneID:10363"
                     /db_xref="HGNC:HGNC:5001"
                     /db_xref="MIM:605534"
ORIGIN      
        1 menlmtsstl pplfadedgs kesndlattg lnhpevpyss gatsstnnpe fvedlsqgql
       61 lqsessnaae gneqrhedeq rskrggwskg rkrkkplrds napkspltgy vrfmnerreq
      121 lrakrpevpf peitrmlgne wsklppeekq ryldeadrdk erymkeleqy qkteaykvfs
      181 rktqdrqkgk shrqdaarqa thdheketev kersvfdipi fteeflnhsk areaelrqlr
      241 ksnmefeern aalqkhvesm rtaveklevd viqersrntv lqqhletlrq vltssfasmp
      301 lpgsgetptv dtidsymnrl hsiilanpqd nenfiatvre vvnrldr
//
LOCUS       XP_005254183             210 aa            linear   PRI 05-AUG-2025
DEFINITION  calcium and integrin-binding family member 2 isoform X1 [Homo
            sapiens].
ACCESSION   XP_005254183
VERSION     XP_005254183.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254126.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..210
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..210
                     /product="calcium and integrin-binding family member 2
                     isoform X1"
                     /calculated_mol_wt=24017
     Region          107..173
                     /region_name="EF-hand_7"
                     /note="EF-hand domain pair; pfam13499"
                     /db_xref="CDD:463900"
     CDS             1..210
                     /gene="CIB2"
                     /gene_synonym="DFNB48; KIP2; USH1J"
                     /coded_by="XM_005254126.4:321..953"
                     /db_xref="GeneID:10518"
                     /db_xref="HGNC:HGNC:24579"
                     /db_xref="MIM:605564"
ORIGIN      
        1 mgnkqtifte eqldnyqdct ffnkkdilkl hsrfyelapn lvpmdyrksp ivhvpmslii
       61 qmpelrenpf kerivaafse dgegnltfnd fvdmfsvlce saprelkany afkiydfntd
      121 nfickedlel tlarltksel deeevvlvcd kvieeadldg dgklgfadfe dmiakapdfl
      181 rcchyrgraw agqsragrdv gaeapitryl
//
LOCUS       XP_047288066             100 aa            linear   PRI 05-AUG-2025
DEFINITION  calcium and integrin-binding family member 2 isoform X2 [Homo
            sapiens].
ACCESSION   XP_047288066
VERSION     XP_047288066.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432110.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..100
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..100
                     /product="calcium and integrin-binding family member 2
                     isoform X2"
                     /calculated_mol_wt=11361
     CDS             1..100
                     /gene="CIB2"
                     /gene_synonym="DFNB48; KIP2; USH1J"
                     /coded_by="XM_047432110.1:321..623"
                     /db_xref="GeneID:10518"
                     /db_xref="HGNC:HGNC:24579"
                     /db_xref="MIM:605564"
ORIGIN      
        1 mgnkqtifte eqldnyqdct ffnkkdilkl hsrfyelapn lvpmdyrksp ivhvpmslii
       61 qmpelrmgkp rlrgiwsllq ghtgcpqsgs galllilhpq
//
LOCUS       XP_011519463             167 aa            linear   PRI 05-AUG-2025
DEFINITION  calcium and integrin-binding family member 2 isoform X3 [Homo
            sapiens].
ACCESSION   XP_011519463
VERSION     XP_011519463.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521161.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..167
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..167
                     /product="calcium and integrin-binding family member 2
                     isoform X3"
                     /calculated_mol_wt=18884
     Region          64..130
                     /region_name="EF-hand_7"
                     /note="EF-hand domain pair; pfam13499"
                     /db_xref="CDD:463900"
     CDS             1..167
                     /gene="CIB2"
                     /gene_synonym="DFNB48; KIP2; USH1J"
                     /coded_by="XM_011521161.2:159..662"
                     /db_xref="GeneID:10518"
                     /db_xref="HGNC:HGNC:24579"
                     /db_xref="MIM:605564"
ORIGIN      
        1 mdyrkspivh vpmsliiqmp elrenpfker ivaafsedge gnltfndfvd mfsvlcesap
       61 relkanyafk iydfntdnfi ckedleltla rltkseldee evvlvcdkvi eeadldgdgk
      121 lgfadfedmi akapdflrcc hyrgrawagq sragrdvgae apitryl
//
LOCUS       XP_006720438             264 aa            linear   PRI 05-AUG-2025
DEFINITION  calcium and integrin-binding protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_006720438
VERSION     XP_006720438.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720375.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..264
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..264
                     /product="calcium and integrin-binding protein 1 isoform
                     X1"
                     /calculated_mol_wt=29284
     Region          83..132
                     /region_name="EFh"
                     /note="EF-hand, calcium binding motif; A diverse
                     superfamily of calcium sensors and calcium signal
                     modulators; most examples in this alignment model have 2
                     active canonical EF hands. Ca2+ binding induces a
                     conformational change in the EF-hand motif, leading to...;
                     cl08302"
                     /db_xref="CDD:415501"
     Region          111..178
                     /region_name="EFh"
                     /note="EF-hand, calcium binding motif; A diverse
                     superfamily of calcium sensors and calcium signal
                     modulators; most examples in this alignment model have 2
                     active canonical EF hands. Ca2+ binding induces a
                     conformational change in the EF-hand motif, leading to...;
                     cd00051"
                     /db_xref="CDD:238008"
     Site            order(116,118,120,127,161,163,165,172)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238008"
     CDS             1..264
                     /gene="CIB1"
                     /gene_synonym="CIB; CIBP; EV3; KIP1; PRKDCIP; SIP2-28"
                     /coded_by="XM_006720375.3:57..851"
                     /db_xref="GeneID:10519"
                     /db_xref="HGNC:HGNC:16920"
                     /db_xref="MIM:602293"
ORIGIN      
        1 mggsgsrlsk ellaeyqdlt fltkqeilla hrrfcellpq eqrsvesslr aqvpfeqils
       61 lpelkanpfk ericrvfsts pakdslsfed fldllsvfsd tatpdikshy afrifdfddd
      121 gtlnredlsr lvncltgege dtrlsasemk qlidnilees didrdgtinl sefqhvisrs
      181 pdfarydsgp psfwvpagsd llplglghgy rrwcqgerkp qsphtgpakl avspragaal
      241 lvktsplpta ivialclysl vikv
//
LOCUS       XP_011519464             353 aa            linear   PRI 05-AUG-2025
DEFINITION  guanine nucleotide-binding protein subunit beta-5 isoform X1 [Homo
            sapiens].
ACCESSION   XP_011519464
VERSION     XP_011519464.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521162.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..353
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..353
                     /product="guanine nucleotide-binding protein subunit
                     beta-5 isoform X1"
                     /calculated_mol_wt=38645
     Region          56..353
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cd00200"
                     /db_xref="CDD:238121"
     Site            order(62,80,84,90..91,98..99,122,126,132..133,151..152,
                     170,174,180..181,194,214,218,224..225,237..238,256,260,
                     266..267,278..279,299,304,310..311,323..324,342,346,
                     352..353)
                     /site_type="active"
                     /note="structural tetrad [active]"
                     /db_xref="CDD:238121"
     Region          66..103
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          109..151
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          156..192
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          199..236
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          242..278
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          286..322
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          328..352
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..353
                     /gene="GNB5"
                     /gene_synonym="GB5; gbeta5; HG2E; IDDCA; LADCI; LDMLS1;
                     LDMLS2"
                     /coded_by="XM_011521162.4:444..1505"
                     /db_xref="GeneID:10681"
                     /db_xref="HGNC:HGNC:4401"
                     /db_xref="MIM:604447"
ORIGIN      
        1 maylscrdsv cpsytstqlg rlrpsptstt gwlelqdmhq vaervealgq fvmktrrtlk
       61 ghgnkvlcmd wckdkrrivs ssqdgkvivw dsfttnkeha vtmpctwvma cayapsgcai
      121 acggldnkcs vypltfdkne nmaakkksva mhtnylsacs ftnsdmqilt asgdgtcalw
      181 dvesgqllqs fhghgadvlc ldlapsetgn tfvsggcdkk amvwdmrsgq cvqafethes
      241 dinsvryyps gdafasgsdd atcrlydlra drevaiyske siifgassvd fslsgrllfa
      301 gyndytinvw dvlkgsrvsi lfghenrvst lrvspdgtaf csgswdhtlr vwa
//
LOCUS       XP_011519466             619 aa            linear   PRI 05-AUG-2025
DEFINITION  ATP-dependent clpX-like chaperone, mitochondrial isoform X1 [Homo
            sapiens].
ACCESSION   XP_011519466
VERSION     XP_011519466.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521164.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..619
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..619
                     /product="ATP-dependent clpX-like chaperone, mitochondrial
                     isoform X1"
                     /calculated_mol_wt=67200
     Region          104..132
                     /region_name="Zn-ribbon"
                     /note="C-terminal zinc ribbon domain of RNA polymerase
                     intrinsic transcript cleavage subunit; cl02609"
                     /db_xref="CDD:445850"
     Site            order(105,108,127,130)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259791"
     Region          172..591
                     /region_name="ClpX"
                     /note="ATP-dependent protease Clp, ATPase subunit ClpX
                     [Posttranslational modification, protein turnover,
                     chaperones]; COG1219"
                     /db_xref="CDD:440832"
     CDS             1..619
                     /gene="CLPX"
                     /gene_synonym="EPP2"
                     /coded_by="XM_011521164.4:190..2049"
                     /db_xref="GeneID:10845"
                     /db_xref="HGNC:HGNC:2088"
                     /db_xref="MIM:615611"
ORIGIN      
        1 mpscgactcg aaavrlitss lasaqrgisg grihmsvlgr lgtfetqilq raplrsftet
       61 payfaskdgi skdgsgdgnk ksasegsskk sgsgnsgkgg nqlrcpkcgd lcthvetfvs
      121 strfvkcekc hhffvvlsea dskksiikep esaaeavkla fqqkpppppk kiynyldkyv
      181 vgqsfakkvl svavynhykr iynnipanlr qqaevekqts ltprellqia gisphgnalg
      241 asmqqqvnqq ipqekrggev ldsshddikl eksnilllgp tgsgktllaq tlakcldvpf
      301 aicdcttltq agyvgedies viakllqdan ynvekaqqgi vfldevdkig svpgihqlrd
      361 vggegvqqgl lkllegtivn vpeknsrklr getvqvdttn ilfvasgafn gldriisrrk
      421 nekylgfgtp snlgkgrraa aaadlanrsg esnthqdiee kdrllrhvea rdliefgmip
      481 efvgrlpvvv plhsldektl vqilteprna vipqyqalfs mdkcelnvte dalkaiarla
      541 lerktgargl rsimekllle pmfevpnsdi vcvevdkevv egkkepgyir aptkesseee
      601 ydsgveeegw prqadaans
//
LOCUS       XP_047288078            1689 aa            linear   PRI 05-AUG-2025
DEFINITION  A disintegrin and metalloproteinase with thrombospondin motifs 7
            isoform X1 [Homo sapiens].
ACCESSION   XP_047288078
VERSION     XP_047288078.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432122.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1689
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1689
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 7 isoform X1"
                     /calculated_mol_wt=183996
     Region          44..184
                     /region_name="Pep_M12B_propep"
                     /note="Reprolysin family propeptide; pfam01562"
                     /db_xref="CDD:460254"
     Region          242..449
                     /region_name="ZnMc_ADAMTS_like"
                     /note="Zinc-dependent metalloprotease, ADAMTS_like
                     subgroup. ADAMs (A Disintegrin And Metalloprotease) are
                     glycoproteins, which play roles in cell signaling, cell
                     fusion, and cell-cell interactions. This particular
                     subfamily represents domain architectures that...;
                     cd04273"
                     /db_xref="CDD:239801"
     Site            order(388..389,392,398)
                     /site_type="active"
                     /db_xref="CDD:239801"
     Region          464..528
                     /region_name="ADAMTS_CR_2"
                     /note="ADAMTS cysteine-rich domain 2; pfam17771"
                     /db_xref="CDD:465496"
     Region          541..593
                     /region_name="TSP1"
                     /note="Thrombospondin type 1 repeats; smart00209"
                     /db_xref="CDD:214559"
     Region          <629..697
                     /region_name="ADAMTS_CR_3"
                     /note="ADAMTS cysteine-rich domain; pfam19236"
                     /db_xref="CDD:437068"
     Region          699..809
                     /region_name="ADAMTS_spacer1"
                     /note="ADAM-TS Spacer 1; pfam05986"
                     /db_xref="CDD:461796"
     Region          825..879
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          883..942
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          946..994
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          <1027..1468
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          1415..1463
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          1466..1521
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          1524..1570
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          1573..1628
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     CDS             1..1689
                     /gene="ADAMTS7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7"
                     /coded_by="XM_047432122.1:245..5314"
                     /db_xref="GeneID:11173"
                     /db_xref="HGNC:HGNC:223"
                     /db_xref="MIM:605009"
ORIGIN      
        1 mpggpsprsp apllrpllll lcalapgapg papgrategr aaldivhpvr vdaggsflsy
       61 elwpralrkr dvsvrrdapa fyelqyrgre lrfnltanqh llapgfvset rrrgglgrah
      121 irahtpachl lgevqdpele gglaaisacd glkgvfqlsn edyfieplds aparpghaqp
      181 hvvykrqape rlaqrgdssa pstcgvqvyp elesrrerwe qrqqwrrprl rrlhqrsvsk
      241 ekwvetlvva dakmveyhgq pqvesyvlti mnmvaglfhd psignpihit ivrlvllede
      301 eedlkithha dntlksfckw qksinmkgda hplhhdtail ltrkdlcaam nrpcetlgls
      361 hvagmcqphr scsinedtgl plaftvahel ghsfgiqhdg sgndcepvgk rpfimspqll
      421 ydaapltwsr csrqyitrfl drgwglcldd ppakdiidfp svppgvlydv shqcrlqyga
      481 ysafcedmdn vchtlwcsvg ttchskldaa vdgtrcgenk wclsgecvpv gfrpeavdgg
      541 wsgwsawsic srscgmgvqs aerqctqptp kykgrycvge rkrfrlcnlq acpagrpsfr
      601 hvqcshfdam lykgqlhtwv pvvndvnpce lhcrpaneyf aeklrdavvd gtpcyqvras
      661 rdlcingick nvgcdfeids gamedrcgvc hgngstchtv sgtfeeaegl gyvdvglipa
      721 gareiriqev aeaanflalr sedpekyfln ggwtiqwngd yqvagttfty arrgnwenlt
      781 spgptkepvw iqllfqesnp gvhyeytihr eagghdevpp pvfswhygpw tkctvtcgrg
      841 vqrqnvycle rqagpvdeeh cdplgrpddq qrkcseqpcp arwwagewql cssscgpggl
      901 srravlcirs vgldeqsale ppacehlprp ptetpcnrhv pcpatwavgn wsqcsvtcge
      961 gtqrrnvlct ndtgvpcdea qqpasevtcs lplcrwplgt lgpegsgsgs sshelfnead
     1021 fiphhlaprp spasspkpgt mgnaieeeap eldlpgpvfv ddfyydynfi nfhedlsygp
     1081 seepdldlag tgdrtppphs hpaapstgsp vpateppaak eegvlgpwsp spwpsqagrs
     1141 ppppseqtpg nplinflpee dtpigapdlg lpslswprvs tdglqtpatp esqndfpvgk
     1201 dsqsqlpppw rdrtnevfkd deepkgrgap hlpprpsstl pplspvgsth sspspdvael
     1261 wtggtvawep alegglgpvd selwptvgva sllpppiapl pemkvrdssl epgtpsfptp
     1321 gpgswdlqtv avwgtflptt ltglghmpep alnpgpkgqp eslspevpls srllstpawd
     1381 spanshrvpe tqplapslae agppadplvv rnagwqagnw secsttcglg avwrpvrcss
     1441 grdedcapag rpqparrchl rpcatwhsgn wskcsrscgg gssvrdvqcv dtrdlrplrp
     1501 fhcqpgpakp pahrpcgaqp clswytsswr ecseacggge qqrlvtcpep glceealrpn
     1561 ttrpcnthpc tqwvvgpwgq csgpcgggvq rrlvkcvntq tglpeedsdq cgheawpess
     1621 rpcgtedcep vepprlslpt vrpgmslrlc enwawvspcp qpwpvhslar glprvsngtt
     1681 grasfpgsc
//
LOCUS       XP_047288079            1436 aa            linear   PRI 05-AUG-2025
DEFINITION  A disintegrin and metalloproteinase with thrombospondin motifs 7
            isoform X2 [Homo sapiens].
ACCESSION   XP_047288079
VERSION     XP_047288079.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432123.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1436
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1436
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 7 isoform X2"
                     /calculated_mol_wt=155890
     Region          1..196
                     /region_name="ZnMc_ADAMTS_like"
                     /note="Zinc-dependent metalloprotease, ADAMTS_like
                     subgroup. ADAMs (A Disintegrin And Metalloprotease) are
                     glycoproteins, which play roles in cell signaling, cell
                     fusion, and cell-cell interactions. This particular
                     subfamily represents domain architectures that...;
                     cd04273"
                     /db_xref="CDD:239801"
     Site            order(135..136,139,145)
                     /site_type="active"
                     /db_xref="CDD:239801"
     Region          211..275
                     /region_name="ADAMTS_CR_2"
                     /note="ADAMTS cysteine-rich domain 2; pfam17771"
                     /db_xref="CDD:465496"
     Region          288..340
                     /region_name="TSP1"
                     /note="Thrombospondin type 1 repeats; smart00209"
                     /db_xref="CDD:214559"
     Region          <376..444
                     /region_name="ADAMTS_CR_3"
                     /note="ADAMTS cysteine-rich domain; pfam19236"
                     /db_xref="CDD:437068"
     Region          446..556
                     /region_name="ADAMTS_spacer1"
                     /note="ADAM-TS Spacer 1; pfam05986"
                     /db_xref="CDD:461796"
     Region          572..626
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          630..689
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          693..741
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          <774..1215
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          1162..1210
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          1213..1268
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          1271..1317
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          1320..1375
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     CDS             1..1436
                     /gene="ADAMTS7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7"
                     /coded_by="XM_047432123.1:503..4813"
                     /db_xref="GeneID:11173"
                     /db_xref="HGNC:HGNC:223"
                     /db_xref="MIM:605009"
ORIGIN      
        1 mveyhgqpqv esyvltimnm vaglfhdpsi gnpihitivr lvlledeeed lkithhadnt
       61 lksfckwqks inmkgdahpl hhdtailltr kdlcaamnrp cetlglshva gmcqphrscs
      121 inedtglpla ftvahelghs fgiqhdgsgn dcepvgkrpf imspqllyda apltwsrcsr
      181 qyitrfldrg wglclddppa kdiidfpsvp pgvlydvshq crlqygaysa fcedmdnvch
      241 tlwcsvgttc hskldaavdg trcgenkwcl sgecvpvgfr peavdggwsg wsawsicsrs
      301 cgmgvqsaer qctqptpkyk grycvgerkr frlcnlqacp agrpsfrhvq cshfdamlyk
      361 gqlhtwvpvv ndvnpcelhc rpaneyfaek lrdavvdgtp cyqvrasrdl cingicknvg
      421 cdfeidsgam edrcgvchgn gstchtvsgt feeaeglgyv dvglipagar eiriqevaea
      481 anflalrsed pekyflnggw tiqwngdyqv agttftyarr gnwenltspg ptkepvwiql
      541 lfqesnpgvh yeytihreag ghdevpppvf swhygpwtkc tvtcgrgvqr qnvyclerqa
      601 gpvdeehcdp lgrpddqqrk cseqpcparw wagewqlcss scgpgglsrr avlcirsvgl
      661 deqsaleppa cehlprppte tpcnrhvpcp atwavgnwsq csvtcgegtq rrnvlctndt
      721 gvpcdeaqqp asevtcslpl crwplgtlgp egsgsgsssh elfneadfip hhlaprpspa
      781 sspkpgtmgn aieeeapeld lpgpvfvddf yydynfinfh edlsygpsee pdldlagtgd
      841 rtppphshpa apstgspvpa teppaakeeg vlgpwspspw psqagrsppp pseqtpgnpl
      901 inflpeedtp igapdlglps lswprvstdg lqtpatpesq ndfpvgkdsq sqlpppwrdr
      961 tnevfkddee pkgrgaphlp prpsstlppl spvgsthssp spdvaelwtg gtvawepale
     1021 gglgpvdsel wptvgvasll pppiaplpem kvrdsslepg tpsfptpgpg swdlqtvavw
     1081 gtflpttltg lghmpepaln pgpkgqpesl spevplssrl lstpawdspa nshrvpetqp
     1141 lapslaeagp padplvvrna gwqagnwsec sttcglgavw rpvrcssgrd edcapagrpq
     1201 parrchlrpc atwhsgnwsk csrscgggss vrdvqcvdtr dlrplrpfhc qpgpakppah
     1261 rpcgaqpcls wytsswrecs eacgggeqqr lvtcpepglc eealrpnttr pcnthpctqw
     1321 vvgpwgqcsg pcgggvqrrl vkcvntqtgl peedsdqcgh eawpessrpc gtedcepvep
     1381 prlslptvrp gmslrlcenw awvspcpqpw pvhslarglp rvsngttgra sfpgsc
//
LOCUS       XP_011519468            1107 aa            linear   PRI 05-AUG-2025
DEFINITION  A disintegrin and metalloproteinase with thrombospondin motifs 7
            isoform X3 [Homo sapiens].
ACCESSION   XP_011519468
VERSION     XP_011519468.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521166.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1107
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1107
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 7 isoform X3"
                     /calculated_mol_wt=118000
     Region          117..227
                     /region_name="ADAMTS_spacer1"
                     /note="ADAM-TS Spacer 1; pfam05986"
                     /db_xref="CDD:461796"
     Region          243..297
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          301..360
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          364..412
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          <445..886
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          833..881
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          884..939
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          942..988
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          991..1046
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     CDS             1..1107
                     /gene="ADAMTS7"
                     /gene_synonym="ADAM-TS 7; ADAM-TS7; ADAMTS-7"
                     /coded_by="XM_011521166.3:284..3607"
                     /db_xref="GeneID:11173"
                     /db_xref="HGNC:HGNC:223"
                     /db_xref="MIM:605009"
ORIGIN      
        1 mvaglagapg psahgavawa yrapsgsars lrpntkadtv wvsasasasa tcrpallaap
       61 psatssaatl tlcstrasct hgcpwsmtnv gcdfeidsga medrcgvchg ngstchtvsg
      121 tfeeaeglgy vdvglipaga reiriqevae aanflalrse dpekyflngg wtiqwngdyq
      181 vagttftyar rgnwenltsp gptkepvwiq llfqesnpgv hyeytihrea gghdevpppv
      241 fswhygpwtk ctvtcgrgvq rqnvyclerq agpvdeehcd plgrpddqqr kcseqpcpar
      301 wwagewqlcs sscgpgglsr ravlcirsvg ldeqsalepp acehlprppt etpcnrhvpc
      361 patwavgnws qcsvtcgegt qrrnvlctnd tgvpcdeaqq pasevtcslp lcrwplgtlg
      421 pegsgsgsss helfneadfi phhlaprpsp asspkpgtmg naieeeapel dlpgpvfvdd
      481 fyydynfinf hedlsygpse epdldlagtg drtppphshp aapstgspvp ateppaakee
      541 gvlgpwspsp wpsqagrspp ppseqtpgnp linflpeedt pigapdlglp slswprvstd
      601 glqtpatpes qndfpvgkds qsqlpppwrd rtnevfkdde epkgrgaphl pprpsstlpp
      661 lspvgsthss pspdvaelwt ggtvawepal egglgpvdse lwptvgvasl lpppiaplpe
      721 mkvrdsslep gtpsfptpgp gswdlqtvav wgtflpttlt glghmpepal npgpkgqpes
      781 lspevplssr llstpawdsp anshrvpetq plapslaeag ppadplvvrn agwqagnwse
      841 csttcglgav wrpvrcssgr dedcapagrp qparrchlrp catwhsgnws kcsrscgggs
      901 svrdvqcvdt rdlrplrpfh cqpgpakppa hrpcgaqpcl swytsswrec seacgggeqq
      961 rlvtcpepgl ceealrpntt rpcnthpctq wvvgpwgqcs gpcgggvqrr lvkcvntqtg
     1021 lpeedsdqcg heawpessrp cgtedcepve pprlslptvr pgmslrlcen wawvspcpqp
     1081 wpvhslargl prvsngttgr asfpgsc
//
LOCUS       XP_011519469             483 aa            linear   PRI 05-AUG-2025
DEFINITION  G-protein coupled receptor 176 isoform X1 [Homo sapiens].
ACCESSION   XP_011519469
VERSION     XP_011519469.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521167.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..483
                     /product="G-protein coupled receptor 176 isoform X1"
                     /calculated_mol_wt=53530
     Region          23..299
                     /region_name="7tm_GPCRs"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; cl28897"
                     /db_xref="CDD:475119"
     Region          45..67
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320135"
     Region          86..108
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320135"
     Region          129..145
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320135"
     Region          171..194
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320135"
     Region          233..255
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320135"
     Region          267..292
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320135"
     CDS             1..483
                     /gene="GPR176"
                     /gene_synonym="HB-954"
                     /coded_by="XM_011521167.4:604..2055"
                     /db_xref="GeneID:11245"
                     /db_xref="HGNC:HGNC:32370"
                     /db_xref="MIM:612183"
ORIGIN      
        1 mepvsghska pstiliengt yvsfsgnfmv lwstcrttvf ksvtnrfikn lacsgicasl
       61 vcvpfdiils tsphccwwiy tmlfckvvkf lhkvfcsvti lsfpaialdr yysvlypler
      121 kisdaksrel vmyiwahavv asvpvfavtn vadiyatstc tevwsnslgh lvyvlvynit
      181 tvivpvvvvf lflilirral sasqkkkvii aalrtpqnti sipyasqrea elhatllsmv
      241 mvfilcsvpy atlvvyqtvl nvpdtsvfll ltavwlpkvs llanpvlflt vnksvrkcli
      301 gtlvqlhhry srrnvvstgs gmaeasleps irsgsqllem fhigqqqifk ptedeeesea
      361 kyigsadfqa keifstcleg eqgpqfapsa pplstvdsvs qvapaapvep etfpdkyslq
      421 fgfgpfelpp qwlsetrnsk krllpplgnt peeliqtkvp kvgrverkms rnnkvsifpk
      481 vds
//
LOCUS       XP_016877362             483 aa            linear   PRI 05-AUG-2025
DEFINITION  G-protein coupled receptor 176 isoform X1 [Homo sapiens].
ACCESSION   XP_016877362
VERSION     XP_016877362.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021873.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..483
                     /product="G-protein coupled receptor 176 isoform X1"
                     /calculated_mol_wt=53530
     Region          23..299
                     /region_name="7tm_GPCRs"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; cl28897"
                     /db_xref="CDD:475119"
     Region          45..67
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320135"
     Region          86..108
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320135"
     Region          129..145
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320135"
     Region          171..194
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320135"
     Region          233..255
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320135"
     Region          267..292
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320135"
     CDS             1..483
                     /gene="GPR176"
                     /gene_synonym="HB-954"
                     /coded_by="XM_017021873.3:520..1971"
                     /db_xref="GeneID:11245"
                     /db_xref="HGNC:HGNC:32370"
                     /db_xref="MIM:612183"
ORIGIN      
        1 mepvsghska pstiliengt yvsfsgnfmv lwstcrttvf ksvtnrfikn lacsgicasl
       61 vcvpfdiils tsphccwwiy tmlfckvvkf lhkvfcsvti lsfpaialdr yysvlypler
      121 kisdaksrel vmyiwahavv asvpvfavtn vadiyatstc tevwsnslgh lvyvlvynit
      181 tvivpvvvvf lflilirral sasqkkkvii aalrtpqnti sipyasqrea elhatllsmv
      241 mvfilcsvpy atlvvyqtvl nvpdtsvfll ltavwlpkvs llanpvlflt vnksvrkcli
      301 gtlvqlhhry srrnvvstgs gmaeasleps irsgsqllem fhigqqqifk ptedeeesea
      361 kyigsadfqa keifstcleg eqgpqfapsa pplstvdsvs qvapaapvep etfpdkyslq
      421 fgfgpfelpp qwlsetrnsk krllpplgnt peeliqtkvp kvgrverkms rnnkvsifpk
      481 vds
//
LOCUS       XP_016877363             352 aa            linear   PRI 05-AUG-2025
DEFINITION  G-protein coupled receptor 176 isoform X2 [Homo sapiens].
ACCESSION   XP_016877363
VERSION     XP_016877363.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021874.3
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 8% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..352
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..352
                     /product="G-protein coupled receptor 176 isoform X2"
                     /calculated_mol_wt=38757
     Region          <1..168
                     /region_name="7tm_GPCRs"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; cl28897"
                     /db_xref="CDD:475119"
     Region          1..14
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:410628"
     Region          40..63
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:410628"
     Region          102..124
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:410628"
     Region          136..161
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:410628"
     CDS             1..352
                     /gene="GPR176"
                     /gene_synonym="HB-954"
                     /coded_by="XM_017021874.3:442..1500"
                     /db_xref="GeneID:11245"
                     /db_xref="HGNC:HGNC:32370"
                     /db_xref="MIM:612183"
ORIGIN      
        1 myiwahavva svpvfavtnv adiyatstct evwsnslghl vyvlvynitt vivpvvvvfl
       61 flilirrals asqkkkviia alrtpqntis ipyasqreae lhatllsmvm vfilcsvpya
      121 tlvvyqtvln vpdtsvflll tavwlpkvsl lanpvlfltv nksvrkclig tlvqlhhrys
      181 rrnvvstgsg maeaslepsi rsgsqllemf higqqqifkp tedeeeseak yigsadfqak
      241 eifstclege qgpqfapsap plstvdsvsq vapaapvepe tfpdkyslqf gfgpfelppq
      301 wlsetrnskk rllpplgntp eeliqtkvpk vgrverkmsr nnkvsifpkv ds
//
LOCUS       XP_024305603             352 aa            linear   PRI 05-AUG-2025
DEFINITION  G-protein coupled receptor 176 isoform X2 [Homo sapiens].
ACCESSION   XP_024305603
VERSION     XP_024305603.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449835.2
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 8% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..352
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..352
                     /product="G-protein coupled receptor 176 isoform X2"
                     /calculated_mol_wt=38757
     Region          <1..168
                     /region_name="7tm_GPCRs"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; cl28897"
                     /db_xref="CDD:475119"
     Region          1..14
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:410628"
     Region          40..63
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:410628"
     Region          102..124
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:410628"
     Region          136..161
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:410628"
     CDS             1..352
                     /gene="GPR176"
                     /gene_synonym="HB-954"
                     /coded_by="XM_024449835.2:558..1616"
                     /db_xref="GeneID:11245"
                     /db_xref="HGNC:HGNC:32370"
                     /db_xref="MIM:612183"
ORIGIN      
        1 myiwahavva svpvfavtnv adiyatstct evwsnslghl vyvlvynitt vivpvvvvfl
       61 flilirrals asqkkkviia alrtpqntis ipyasqreae lhatllsmvm vfilcsvpya
      121 tlvvyqtvln vpdtsvflll tavwlpkvsl lanpvlfltv nksvrkclig tlvqlhhrys
      181 rrnvvstgsg maeaslepsi rsgsqllemf higqqqifkp tedeeeseak yigsadfqak
      241 eifstclege qgpqfapsap plstvdsvsq vapaapvepe tfpdkyslqf gfgpfelppq
      301 wlsetrnskk rllpplgntp eeliqtkvpk vgrverkmsr nnkvsifpkv ds
//
LOCUS       XP_016877367             352 aa            linear   PRI 05-AUG-2025
DEFINITION  G-protein coupled receptor 176 isoform X2 [Homo sapiens].
ACCESSION   XP_016877367
VERSION     XP_016877367.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021878.3
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 32% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..352
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..352
                     /product="G-protein coupled receptor 176 isoform X2"
                     /calculated_mol_wt=38757
     Region          <1..168
                     /region_name="7tm_GPCRs"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; cl28897"
                     /db_xref="CDD:475119"
     Region          1..14
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:410628"
     Region          40..63
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:410628"
     Region          102..124
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:410628"
     Region          136..161
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:410628"
     CDS             1..352
                     /gene="GPR176"
                     /gene_synonym="HB-954"
                     /coded_by="XM_017021878.3:477..1535"
                     /db_xref="GeneID:11245"
                     /db_xref="HGNC:HGNC:32370"
                     /db_xref="MIM:612183"
ORIGIN      
        1 myiwahavva svpvfavtnv adiyatstct evwsnslghl vyvlvynitt vivpvvvvfl
       61 flilirrals asqkkkviia alrtpqntis ipyasqreae lhatllsmvm vfilcsvpya
      121 tlvvyqtvln vpdtsvflll tavwlpkvsl lanpvlfltv nksvrkclig tlvqlhhrys
      181 rrnvvstgsg maeaslepsi rsgsqllemf higqqqifkp tedeeeseak yigsadfqak
      241 eifstclege qgpqfapsap plstvdsvsq vapaapvepe tfpdkyslqf gfgpfelppq
      301 wlsetrnskk rllpplgntp eeliqtkvpk vgrverkmsr nnkvsifpkv ds
//
LOCUS       XP_016877368             123 aa            linear   PRI 05-AUG-2025
DEFINITION  calcineurin B homologous protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_016877368
VERSION     XP_016877368.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021879.3
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 1% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..123
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..123
                     /product="calcineurin B homologous protein 1 isoform X1"
                     /calculated_mol_wt=14139
     Region          <9..>73
                     /region_name="PPP2R3"
                     /note="serine/threonine protein phosphatase 2A regulatory
                     subunit B'; cl41751"
                     /db_xref="CDD:425382"
     CDS             1..123
                     /gene="CHP1"
                     /gene_synonym="CHP; p22; p24; Sid470p; SLC9A1BP; SPAX9"
                     /coded_by="XM_017021879.3:116..487"
                     /db_xref="GeneID:11261"
                     /db_xref="HGNC:HGNC:17433"
                     /db_xref="MIM:606988"
ORIGIN      
        1 mgsrastllr deeleeikke tgfshsqitr lysrftsldk gengtlsred fqripelain
       61 plgdriinaf fpegedqvnf rgfmrtlahf rpiedneksk dvngpeplns rsnklhleee
      121 ryi
//
LOCUS       XP_047288080             112 aa            linear   PRI 05-AUG-2025
DEFINITION  calcineurin B homologous protein 1 isoform X2 [Homo sapiens].
ACCESSION   XP_047288080
VERSION     XP_047288080.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432124.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..112
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..112
                     /product="calcineurin B homologous protein 1 isoform X2"
                     /calculated_mol_wt=12819
     Region          31..97
                     /region_name="EFh"
                     /note="EF-hand, calcium binding motif; A diverse
                     superfamily of calcium sensors and calcium signal
                     modulators; most examples in this alignment model have 2
                     active canonical EF hands. Ca2+ binding induces a
                     conformational change in the EF-hand motif, leading to...;
                     cd00051"
                     /db_xref="CDD:238008"
     Site            order(40,42,44,51,81,83,85,92)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238008"
     CDS             1..112
                     /gene="CHP1"
                     /gene_synonym="CHP; p22; p24; Sid470p; SLC9A1BP; SPAX9"
                     /coded_by="XM_047432124.1:221..559"
                     /db_xref="GeneID:11261"
                     /db_xref="HGNC:HGNC:17433"
                     /db_xref="MIM:606988"
ORIGIN      
        1 mrtlahfrpi ednekskdvn gpeplnsrsn klhfafrlyd ldkdekisrd ellqvlrmmv
       61 gvnisdeqlg siadrtiqea dqdgdsaisf tefvkvlekv dveqkmsirf lh
//
LOCUS       XP_047288081             112 aa            linear   PRI 05-AUG-2025
DEFINITION  calcineurin B homologous protein 1 isoform X2 [Homo sapiens].
ACCESSION   XP_047288081
VERSION     XP_047288081.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432125.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..112
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..112
                     /product="calcineurin B homologous protein 1 isoform X2"
                     /calculated_mol_wt=12819
     Region          31..97
                     /region_name="EFh"
                     /note="EF-hand, calcium binding motif; A diverse
                     superfamily of calcium sensors and calcium signal
                     modulators; most examples in this alignment model have 2
                     active canonical EF hands. Ca2+ binding induces a
                     conformational change in the EF-hand motif, leading to...;
                     cd00051"
                     /db_xref="CDD:238008"
     Site            order(40,42,44,51,81,83,85,92)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238008"
     CDS             1..112
                     /gene="CHP1"
                     /gene_synonym="CHP; p22; p24; Sid470p; SLC9A1BP; SPAX9"
                     /coded_by="XM_047432125.1:292..630"
                     /db_xref="GeneID:11261"
                     /db_xref="HGNC:HGNC:17433"
                     /db_xref="MIM:606988"
ORIGIN      
        1 mrtlahfrpi ednekskdvn gpeplnsrsn klhfafrlyd ldkdekisrd ellqvlrmmv
       61 gvnisdeqlg siadrtiqea dqdgdsaisf tefvkvlekv dveqkmsirf lh
//
LOCUS       XP_006720445             438 aa            linear   PRI 05-AUG-2025
DEFINITION  neuronal acetylcholine receptor subunit alpha-3 isoform X1 [Homo
            sapiens].
ACCESSION   XP_006720445
VERSION     XP_006720445.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720382.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..438
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..438
                     /product="neuronal acetylcholine receptor subunit alpha-3
                     isoform X1"
                     /calculated_mol_wt=49921
     Region          1..174
                     /region_name="LGIC_ECD"
                     /note="extracellular domain (ECD) of Cys-loop
                     neurotransmitter-gated ion channels (also known as
                     ligand-gated ion channel (LGIC)); cl28912"
                     /db_xref="CDD:475126"
     Site            order(3,5,11..12,19,41,43,52..53,55,57..58,69..71,73,83,
                     85,87,91,113,173)
                     /site_type="other"
                     /note="pentamer interface [polypeptide binding]"
                     /db_xref="CDD:349817"
     Region          181..428
                     /region_name="Neur_chan_memb"
                     /note="Neurotransmitter-gated ion-channel transmembrane
                     region; pfam02932"
                     /db_xref="CDD:460753"
     CDS             1..438
                     /gene="CHRNA3"
                     /gene_synonym="BAIPRCK; LNCR2; NACHRA3; PAOD2"
                     /coded_by="XM_006720382.4:747..2063"
                     /db_xref="GeneID:1136"
                     /db_xref="HGNC:HGNC:1957"
                     /db_xref="MIM:118503"
ORIGIN      
        1 msqlvkvdev nqimetnlwl kqiwndyklk wnpsdyggae fmrvpaqkiw kpdivlynna
       61 vgdfqvddkt kallkytgev twippaifks sckidvtyfp fdyqnctmkf gswsydkaki
      121 dlvligssmn lkdywesgew aiikapgykh dikyncceei ypdityslyi rrlplfytin
      181 liipcllisf ltvlvfylps dcgekvtlci svllsltvfl lvitetipst slvipligey
      241 llftmifvtl sivitvfvln vhyrtpttht mpswvktvfl nllprvmfmt rptsnegnaq
      301 kprplygael snlncfsrae skgckegypc qdgmcgychh rrikisnfsa nltrsssses
      361 vdavlslsal speikeaiqs vkyiaenmka qneakeiqdd wkyvamvidr iflwvftlvc
      421 ilgtaglflq plmareda
//
LOCUS       XP_011519478             486 aa            linear   PRI 05-AUG-2025
DEFINITION  neuronal acetylcholine receptor subunit alpha-7 isoform X1 [Homo
            sapiens].
ACCESSION   XP_011519478
VERSION     XP_011519478.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521176.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Jun 6, 2016 this sequence version replaced XP_011519478.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..486
                     /product="neuronal acetylcholine receptor subunit alpha-7
                     isoform X1"
                     /calculated_mol_wt=53920
     Region          50..474
                     /region_name="LIC"
                     /note="Cation transporter family protein; TIGR00860"
                     /db_xref="CDD:273305"
     CDS             1..486
                     /gene="CHRNA7"
                     /gene_synonym="CHRNA7-2; nAChR7; NACHRA7"
                     /coded_by="XM_011521176.4:478..1938"
                     /db_xref="GeneID:1139"
                     /db_xref="HGNC:HGNC:1960"
                     /db_xref="MIM:118511"
ORIGIN      
        1 mdsepafgaa sgegglflpa gqgligedta padlllpesh rtslrrgkgd eknqvlttni
       61 wlqmswtdhy lqwnvseypg vktvrfpdgq iwkpdillyn saderfdatf htnvlvnssg
      121 hcqylppgif ksscyidvrw fpfdvqhckl kfgswsyggw sldlqmqead isgyipngew
      181 dlvgipgkrs erfyecckep ypdvtftvtm rrrtlyygln llipcvlisa lallvfllpa
      241 dsgekislgi tvllsltvfm llvaeimpat sdsvpliaqy fastmiivgl svvvtvivlq
      301 yhhhdpdggk mpkwtrvill nwcawflrmk rpgedkvrpa cqhkqrrcsl asvemsavap
      361 ppasngnlly igfrgldgvh cvptpdsgvv cgrmacspth dehllhggqp pegdpdlaki
      421 leevryianr frcqdeseav csewkfaacv vdrlclmafs vftiictigi lmsapnfvea
      481 vskdfa
//
LOCUS       XP_047288082             441 aa            linear   PRI 05-AUG-2025
DEFINITION  neuronal acetylcholine receptor subunit alpha-7 isoform X2 [Homo
            sapiens].
ACCESSION   XP_047288082
VERSION     XP_047288082.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432126.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..441
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..441
                     /product="neuronal acetylcholine receptor subunit alpha-7
                     isoform X2"
                     /calculated_mol_wt=48802
     Region          <56..429
                     /region_name="LIC"
                     /note="Cation transporter family protein; cl42365"
                     /db_xref="CDD:455710"
     CDS             1..441
                     /gene="CHRNA7"
                     /gene_synonym="CHRNA7-2; nAChR7; NACHRA7"
                     /coded_by="XM_047432126.1:116..1441"
                     /db_xref="GeneID:1139"
                     /db_xref="HGNC:HGNC:1960"
                     /db_xref="MIM:118511"
ORIGIN      
        1 marfgnqtff sitavmtnsr kcwpmgctag ahsldphprl csllcigefc grdgcsader
       61 fdatfhtnvl vnssghcqyl ppgifksscy idvrwfpfdv qhcklkfgsw syggwsldlq
      121 mqeadisgyi pngewdlvgi pgkrserfye cckepypdvt ftvtmrrrtl yyglnllipc
      181 vlisalallv fllpadsgek islgitvlls ltvfmllvae impatsdsvp liaqyfastm
      241 iivglsvvvt vivlqyhhhd pdggkmpkwt rvillnwcaw flrmkrpged kvrpacqhkq
      301 rrcslasvem savapppasn gnllyigfrg ldgvhcvptp dsgvvcgrma cspthdehll
      361 hggqppegdp dlakileevr yianrfrcqd eseavcsewk faacvvdrlc lmafsvftii
      421 ctigilmsap nfveavskdf a
//
LOCUS       XP_047288083             440 aa            linear   PRI 05-AUG-2025
DEFINITION  neuronal acetylcholine receptor subunit alpha-7 isoform X3 [Homo
            sapiens].
ACCESSION   XP_047288083
VERSION     XP_047288083.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432127.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..440
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..440
                     /product="neuronal acetylcholine receptor subunit alpha-7
                     isoform X3"
                     /calculated_mol_wt=48731
     Region          <55..428
                     /region_name="LIC"
                     /note="Cation transporter family protein; cl42365"
                     /db_xref="CDD:455710"
     CDS             1..440
                     /gene="CHRNA7"
                     /gene_synonym="CHRNA7-2; nAChR7; NACHRA7"
                     /coded_by="XM_047432127.1:116..1438"
                     /db_xref="GeneID:1139"
                     /db_xref="HGNC:HGNC:1960"
                     /db_xref="MIM:118511"
ORIGIN      
        1 marfgnqtff sitvmtnsrk cwpmgctaga hsldphprlc sllcigefcg rdgcsaderf
       61 datfhtnvlv nssghcqylp pgifksscyi dvrwfpfdvq hcklkfgsws yggwsldlqm
      121 qeadisgyip ngewdlvgip gkrserfyec ckepypdvtf tvtmrrrtly yglnllipcv
      181 lisalallvf llpadsgeki slgitvllsl tvfmllvaei mpatsdsvpl iaqyfastmi
      241 ivglsvvvtv ivlqyhhhdp dggkmpkwtr villnwcawf lrmkrpgedk vrpacqhkqr
      301 rcslasvems avapppasng nllyigfrgl dgvhcvptpd sgvvcgrmac spthdehllh
      361 ggqppegdpd lakileevry ianrfrcqde seavcsewkf aacvvdrlcl mafsvftiic
      421 tigilmsapn fveavskdfa
//
LOCUS       XP_011519479             401 aa            linear   PRI 05-AUG-2025
DEFINITION  neuronal acetylcholine receptor subunit alpha-7 isoform X4 [Homo
            sapiens].
ACCESSION   XP_011519479
VERSION     XP_011519479.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521177.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..401
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..401
                     /product="neuronal acetylcholine receptor subunit alpha-7
                     isoform X4"
                     /calculated_mol_wt=44543
     Region          <17..389
                     /region_name="LIC"
                     /note="Cation transporter family protein; cl42365"
                     /db_xref="CDD:455710"
     CDS             1..401
                     /gene="CHRNA7"
                     /gene_synonym="CHRNA7-2; nAChR7; NACHRA7"
                     /coded_by="XM_011521177.3:358..1563"
                     /db_xref="GeneID:1139"
                     /db_xref="HGNC:HGNC:1960"
                     /db_xref="MIM:118511"
ORIGIN      
        1 mkniqkslsh kslshsader fdatfhtnvl vnssghcqyl ppgifksscy idvrwfpfdv
       61 qhcklkfgsw syggwsldlq mqeadisgyi pngewdlvgi pgkrserfye cckepypdvt
      121 ftvtmrrrtl yyglnllipc vlisalallv fllpadsgek islgitvlls ltvfmllvae
      181 impatsdsvp liaqyfastm iivglsvvvt vivlqyhhhd pdggkmpkwt rvillnwcaw
      241 flrmkrpged kvrpacqhkq rrcslasvem savapppasn gnllyigfrg ldgvhcvptp
      301 dsgvvcgrma cspthdehll hggqppegdp dlakileevr yianrfrcqd eseavcsewk
      361 faacvvdrlc lmafsvftii ctigilmsap nfveavskdf a
//
LOCUS       XP_011519480             380 aa            linear   PRI 05-AUG-2025
DEFINITION  neuronal acetylcholine receptor subunit alpha-7 isoform X5 [Homo
            sapiens].
ACCESSION   XP_011519480
VERSION     XP_011519480.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521178.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..380
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..380
                     /product="neuronal acetylcholine receptor subunit alpha-7
                     isoform X5"
                     /calculated_mol_wt=42561
     Region          50..229
                     /region_name="LGIC_ECD_nAChR_A7"
                     /note="extracellular domain of neuronal acetylcholine
                     receptor subunit alpha 7 (CHRNA7); cd19020"
                     /db_xref="CDD:349821"
     Site            order(61,63,69..70,77,99,101,110..111,113,115..116,120,
                     122..123,127..129,131,141,143,145,149,171,229)
                     /site_type="other"
                     /note="pentamer interface [polypeptide binding]"
                     /db_xref="CDD:349821"
     Region          150..164
                     /region_name="Cys-loop"
                     /note="Cys-loop [structural motif]"
                     /db_xref="CDD:349821"
     Region          231..>293
                     /region_name="LGIC_TM_cation"
                     /note="transmembrane domain of Cys-loop
                     neurotransmitter-gated ion channels, includes 5HT3, nAChR,
                     and ZAC; cd19051"
                     /db_xref="CDD:349853"
     Region          231..255
                     /region_name="TM1 helix"
                     /note="TM1 helix [structural motif]"
                     /db_xref="CDD:349853"
     Region          263..284
                     /region_name="TM2 helix"
                     /note="TM2 helix [structural motif]"
                     /db_xref="CDD:349853"
     CDS             1..380
                     /gene="CHRNA7"
                     /gene_synonym="CHRNA7-2; nAChR7; NACHRA7"
                     /coded_by="XM_011521178.4:81..1223"
                     /db_xref="GeneID:1139"
                     /db_xref="HGNC:HGNC:1960"
                     /db_xref="MIM:118511"
ORIGIN      
        1 mrcspggvwl alaasllhvs lqgefqrkly kelvknynpl erpvandsqp ltvyfslsll
       61 qimdvdeknq vlttniwlqm swtdhylqwn vseypgvktv rfpdgqiwkp dillynsade
      121 rfdatfhtnv lvnssghcqy lppgifkssc yidvrwfpfd vqhcklkfgs wsyggwsldl
      181 qmqeadisgy ipngewdlvg ipgkrserfy ecckepypdv tftvtmrrrt lyyglnllip
      241 cvlisalall vfllpadsge kislgitvll sltvfmllva eimpatsdsv plidqshpse
      301 lvrvvpanee arggqgapgl paqaaalqpg qcgderrgaa arqqrepavh rlprpgrral
      361 cpdprlwgsv wphgllphar
//
LOCUS       XP_047288084             420 aa            linear   PRI 05-AUG-2025
DEFINITION  serine beta-lactamase-like protein LACTB, mitochondrial isoform X1
            [Homo sapiens].
ACCESSION   XP_047288084
VERSION     XP_047288084.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432128.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..420
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..420
                     /product="serine beta-lactamase-like protein LACTB,
                     mitochondrial isoform X1"
                     /calculated_mol_wt=46381
     Region          112..>376
                     /region_name="AmpC"
                     /note="CubicO group peptidase, beta-lactamase class C
                     family [Defense mechanisms]; COG1680"
                     /db_xref="CDD:441286"
     CDS             1..420
                     /gene="LACTB"
                     /gene_synonym="G24; MRPL56"
                     /coded_by="XM_047432128.1:12..1274"
                     /db_xref="GeneID:114294"
                     /db_xref="HGNC:HGNC:16468"
                     /db_xref="MIM:608440"
ORIGIN      
        1 myrlmsavta raaapgglas scgrrgvhqr aglpplghgw vgglglglgl algvklaggl
       61 rgaapaqspa apdpeaspla eppqeqslap wspqtpappc srcfaraies srdllhrikd
      121 evgapgivvg vsvdgkevws eglgyadven rvpckpetvm riasiskslt mvalaklwea
      181 gkldldipvq hyvpefpeke yegekvsvtt rllishlsgi rhyekdikkv keekaykalk
      241 mmkenvafeq ekegksnekn dftkfkteqe neakcrnskp gkkkndfeqg elylrekfen
      301 sieslrlfkn dplffkpgsq flystfgytl laaiverasg ckyldymqki fhdldmlttv
      361 qeenepviyn raswhsiirr cgpgrwltpv ipslweaevg gshetkfets lanmakphly
//
LOCUS       XP_011519489             495 aa            linear   PRI 05-AUG-2025
DEFINITION  neuronal acetylcholine receptor subunit beta-4 isoform X1 [Homo
            sapiens].
ACCESSION   XP_011519489
VERSION     XP_011519489.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521187.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..495
                     /product="neuronal acetylcholine receptor subunit beta-4
                     isoform X1"
                     /calculated_mol_wt=55819
     Region          21..477
                     /region_name="LIC"
                     /note="Cation transporter family protein; cl42365"
                     /db_xref="CDD:455710"
     Region          51..228
                     /region_name="LGIC_ECD"
                     /note="extracellular domain (ECD) of Cys-loop
                     neurotransmitter-gated ion channels (also known as
                     ligand-gated ion channel (LGIC)); cl28912"
                     /db_xref="CDD:475126"
     Site            order(61,63,69..70,77,99,101,110..111,113,115..116,
                     127..129,131,141,143,145,149,171,228)
                     /site_type="other"
                     /note="pentamer interface [polypeptide binding]"
                     /db_xref="CDD:349828"
     CDS             1..495
                     /gene="CHRNB4"
                     /coded_by="XM_011521187.3:1356..2843"
                     /db_xref="GeneID:1143"
                     /db_xref="HGNC:HGNC:1964"
                     /db_xref="MIM:118509"
ORIGIN      
        1 mggsllapap dhivlwncrv anaeeklmdd llnktrynnl irpatsssql isiklqlsla
       61 qlisvnereq imttnvwlkq ewtdyrltwn ssryegvnil ripakriwlp divlynnadg
      121 tyevsvytnl ivrsngsvlw lppaiyksac kievkyfpfd qqnctlkfrs wtydhteidm
      181 vlmtptasmd dftpsgewdi valpgrrtvn pqdpsyvdvt ydfiikrkpl fytinliipc
      241 vlttllailv fylpsdcgek mtlcisvlla ltfflllisk ivpptsldvp ligkylmftm
      301 vlvtfsivts vcvlnvhhrs psthtmapwv krcflhklpt flfmkrpgpd ssparafpps
      361 kscvtkpeat atstspsnfy gnsmyfvnpa saaskspags tpvaiprdfw lrssgrfrqd
      421 vqealegvsf iaqhmkndde dqsvvedwky vamvvdrlfl wvfmfvcvlg tvglflpplf
      481 qthaasegpy aaqrd
//
LOCUS       XP_011519488             495 aa            linear   PRI 05-AUG-2025
DEFINITION  neuronal acetylcholine receptor subunit beta-4 isoform X1 [Homo
            sapiens].
ACCESSION   XP_011519488
VERSION     XP_011519488.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521186.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..495
                     /product="neuronal acetylcholine receptor subunit beta-4
                     isoform X1"
                     /calculated_mol_wt=55819
     Region          21..477
                     /region_name="LIC"
                     /note="Cation transporter family protein; cl42365"
                     /db_xref="CDD:455710"
     Region          51..228
                     /region_name="LGIC_ECD"
                     /note="extracellular domain (ECD) of Cys-loop
                     neurotransmitter-gated ion channels (also known as
                     ligand-gated ion channel (LGIC)); cl28912"
                     /db_xref="CDD:475126"
     Site            order(61,63,69..70,77,99,101,110..111,113,115..116,
                     127..129,131,141,143,145,149,171,228)
                     /site_type="other"
                     /note="pentamer interface [polypeptide binding]"
                     /db_xref="CDD:349828"
     CDS             1..495
                     /gene="CHRNB4"
                     /coded_by="XM_011521186.3:1450..2937"
                     /db_xref="GeneID:1143"
                     /db_xref="HGNC:HGNC:1964"
                     /db_xref="MIM:118509"
ORIGIN      
        1 mggsllapap dhivlwncrv anaeeklmdd llnktrynnl irpatsssql isiklqlsla
       61 qlisvnereq imttnvwlkq ewtdyrltwn ssryegvnil ripakriwlp divlynnadg
      121 tyevsvytnl ivrsngsvlw lppaiyksac kievkyfpfd qqnctlkfrs wtydhteidm
      181 vlmtptasmd dftpsgewdi valpgrrtvn pqdpsyvdvt ydfiikrkpl fytinliipc
      241 vlttllailv fylpsdcgek mtlcisvlla ltfflllisk ivpptsldvp ligkylmftm
      301 vlvtfsivts vcvlnvhhrs psthtmapwv krcflhklpt flfmkrpgpd ssparafpps
      361 kscvtkpeat atstspsnfy gnsmyfvnpa saaskspags tpvaiprdfw lrssgrfrqd
      421 vqealegvsf iaqhmkndde dqsvvedwky vamvvdrlfl wvfmfvcvlg tvglflpplf
      481 qthaasegpy aaqrd
//
LOCUS       XP_016877374             468 aa            linear   PRI 05-AUG-2025
DEFINITION  neuronal acetylcholine receptor subunit beta-4 isoform X2 [Homo
            sapiens].
ACCESSION   XP_016877374
VERSION     XP_016877374.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021885.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..468
                     /product="neuronal acetylcholine receptor subunit beta-4
                     isoform X2"
                     /calculated_mol_wt=52932
     Region          2..450
                     /region_name="LIC"
                     /note="Cation transporter family protein; cl42365"
                     /db_xref="CDD:455710"
     Region          24..201
                     /region_name="LGIC_ECD"
                     /note="extracellular domain (ECD) of Cys-loop
                     neurotransmitter-gated ion channels (also known as
                     ligand-gated ion channel (LGIC)); cl28912"
                     /db_xref="CDD:475126"
     Site            order(34,36,42..43,50,72,74,83..84,86,88..89,100..102,104,
                     114,116,118,122,144,201)
                     /site_type="other"
                     /note="pentamer interface [polypeptide binding]"
                     /db_xref="CDD:349828"
     CDS             1..468
                     /gene="CHRNB4"
                     /coded_by="XM_017021885.2:293..1699"
                     /db_xref="GeneID:1143"
                     /db_xref="HGNC:HGNC:1964"
                     /db_xref="MIM:118509"
ORIGIN      
        1 mddllnktry nnlirpatss sqlisiklql slaqlisvne reqimttnvw lkqewtdyrl
       61 twnssryegv nilripakri wlpdivlynn adgtyevsvy tnlivrsngs vlwlppaiyk
      121 sackievkyf pfdqqnctlk frswtydhte idmvlmtpta smddftpsge wdivalpgrr
      181 tvnpqdpsyv dvtydfiikr kplfytinli ipcvlttlla ilvfylpsdc gekmtlcisv
      241 llaltfflll iskivpptsl dvpligkylm ftmvlvtfsi vtsvcvlnvh hrspsthtma
      301 pwvkrcflhk lptflfmkrp gpdssparaf ppskscvtkp eatatstsps nfygnsmyfv
      361 npasaasksp agstpvaipr dfwlrssgrf rqdvqealeg vsfiaqhmkn ddedqsvved
      421 wkyvamvvdr lflwvfmfvc vlgtvglflp plfqthaase gpyaaqrd
//
LOCUS       XP_016877375             468 aa            linear   PRI 05-AUG-2025
DEFINITION  neuronal acetylcholine receptor subunit beta-4 isoform X2 [Homo
            sapiens].
ACCESSION   XP_016877375
VERSION     XP_016877375.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021886.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..468
                     /product="neuronal acetylcholine receptor subunit beta-4
                     isoform X2"
                     /calculated_mol_wt=52932
     Region          2..450
                     /region_name="LIC"
                     /note="Cation transporter family protein; cl42365"
                     /db_xref="CDD:455710"
     Region          24..201
                     /region_name="LGIC_ECD"
                     /note="extracellular domain (ECD) of Cys-loop
                     neurotransmitter-gated ion channels (also known as
                     ligand-gated ion channel (LGIC)); cl28912"
                     /db_xref="CDD:475126"
     Site            order(34,36,42..43,50,72,74,83..84,86,88..89,100..102,104,
                     114,116,118,122,144,201)
                     /site_type="other"
                     /note="pentamer interface [polypeptide binding]"
                     /db_xref="CDD:349828"
     CDS             1..468
                     /gene="CHRNB4"
                     /coded_by="XM_017021886.2:2105..3511"
                     /db_xref="GeneID:1143"
                     /db_xref="HGNC:HGNC:1964"
                     /db_xref="MIM:118509"
ORIGIN      
        1 mddllnktry nnlirpatss sqlisiklql slaqlisvne reqimttnvw lkqewtdyrl
       61 twnssryegv nilripakri wlpdivlynn adgtyevsvy tnlivrsngs vlwlppaiyk
      121 sackievkyf pfdqqnctlk frswtydhte idmvlmtpta smddftpsge wdivalpgrr
      181 tvnpqdpsyv dvtydfiikr kplfytinli ipcvlttlla ilvfylpsdc gekmtlcisv
      241 llaltfflll iskivpptsl dvpligkylm ftmvlvtfsi vtsvcvlnvh hrspsthtma
      301 pwvkrcflhk lptflfmkrp gpdssparaf ppskscvtkp eatatstsps nfygnsmyfv
      361 npasaasksp agstpvaipr dfwlrssgrf rqdvqealeg vsfiaqhmkn ddedqsvved
      421 wkyvamvvdr lflwvfmfvc vlgtvglflp plfqthaase gpyaaqrd
//
LOCUS       XP_016877376             463 aa            linear   PRI 05-AUG-2025
DEFINITION  neuronal acetylcholine receptor subunit beta-4 isoform X3 [Homo
            sapiens].
ACCESSION   XP_016877376
VERSION     XP_016877376.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021887.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..463
                     /product="neuronal acetylcholine receptor subunit beta-4
                     isoform X3"
                     /calculated_mol_wt=52365
     Region          5..419
                     /region_name="LIC"
                     /note="Cation transporter family protein; cl42365"
                     /db_xref="CDD:455710"
     Region          54..231
                     /region_name="LGIC_ECD"
                     /note="extracellular domain (ECD) of Cys-loop
                     neurotransmitter-gated ion channels (also known as
                     ligand-gated ion channel (LGIC)); cl28912"
                     /db_xref="CDD:475126"
     Site            order(64,66,72..73,80,102,104,113..114,116,118..119,
                     130..132,134,144,146,148,152,174,231)
                     /site_type="other"
                     /note="pentamer interface [polypeptide binding]"
                     /db_xref="CDD:349787"
     CDS             1..463
                     /gene="CHRNB4"
                     /coded_by="XM_017021887.2:78..1469"
                     /db_xref="GeneID:1143"
                     /db_xref="HGNC:HGNC:1964"
                     /db_xref="MIM:118509"
ORIGIN      
        1 mrrapslvlf flvalcgrgn crvanaeekl mddllnktry nnlirpatss sqlisiklql
       61 slaqlisvne reqimttnvw lkqewtdyrl twnssryegv nilripakri wlpdivlynn
      121 adgtyevsvy tnlivrsngs vlwlppaiyk sackievkyf pfdqqnctlk frswtydhte
      181 idmvlmtpta smddftpsge wdivalpgrr tvnpqdpsyv dvtydfiikr kplfytinli
      241 ipcvlttlla ilvfylpsdc gekmtlcisv llaltfflll iskivpptsl dvpligkylm
      301 ftmvlvtfsi vtsvcvlnvh hrspsthtma pwvkrcflhk lptflfmkrp gpdssparaf
      361 ppskscvtkp eatatstsps nfygnsmyfv npasaasksp agstpvaipr dfwlrssgrf
      421 rqdvqealeg vsfiaqhmkn ddedqsvsqk qtprwglgcr wft
//
LOCUS       XP_016877377             462 aa            linear   PRI 05-AUG-2025
DEFINITION  neuronal acetylcholine receptor subunit beta-4 isoform X4 [Homo
            sapiens].
ACCESSION   XP_016877377
VERSION     XP_016877377.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021888.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..462
                     /product="neuronal acetylcholine receptor subunit beta-4
                     isoform X4"
                     /calculated_mol_wt=52296
     Region          5..419
                     /region_name="LIC"
                     /note="Cation transporter family protein; cl42365"
                     /db_xref="CDD:455710"
     Region          54..231
                     /region_name="LGIC_ECD"
                     /note="extracellular domain (ECD) of Cys-loop
                     neurotransmitter-gated ion channels (also known as
                     ligand-gated ion channel (LGIC)); cl28912"
                     /db_xref="CDD:475126"
     Site            order(64,66,72..73,80,102,104,113..114,116,118..119,
                     130..132,134,144,146,148,152,174,231)
                     /site_type="other"
                     /note="pentamer interface [polypeptide binding]"
                     /db_xref="CDD:349787"
     CDS             1..462
                     /gene="CHRNB4"
                     /coded_by="XM_017021888.2:78..1466"
                     /db_xref="GeneID:1143"
                     /db_xref="HGNC:HGNC:1964"
                     /db_xref="MIM:118509"
ORIGIN      
        1 mrrapslvlf flvalcgrgn crvanaeekl mddllnktry nnlirpatss sqlisiklql
       61 slaqlisvne reqimttnvw lkqewtdyrl twnssryegv nilripakri wlpdivlynn
      121 adgtyevsvy tnlivrsngs vlwlppaiyk sackievkyf pfdqqnctlk frswtydhte
      181 idmvlmtpta smddftpsge wdivalpgrr tvnpqdpsyv dvtydfiikr kplfytinli
      241 ipcvlttlla ilvfylpsdc gekmtlcisv llaltfflll iskivpptsl dvpligkylm
      301 ftmvlvtfsi vtsvcvlnvh hrspsthtma pwvkrcflhk lptflfmkrp gpdssparaf
      361 ppskscvtkp eatatstsps nfygnsmyfv npasaasksp agstpvaipr dfwlrssgrf
      421 rqdvqealeg vsfiaqhmkn ddedqsvmpa cqnkhpwcwr kp
//
LOCUS       XP_016877378             449 aa            linear   PRI 05-AUG-2025
DEFINITION  neuronal acetylcholine receptor subunit beta-4 isoform X5 [Homo
            sapiens].
ACCESSION   XP_016877378
VERSION     XP_016877378.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021889.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..449
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..449
                     /product="neuronal acetylcholine receptor subunit beta-4
                     isoform X5"
                     /calculated_mol_wt=50636
     Region          5..419
                     /region_name="LIC"
                     /note="Cation transporter family protein; cl42365"
                     /db_xref="CDD:455710"
     Region          54..231
                     /region_name="LGIC_ECD"
                     /note="extracellular domain (ECD) of Cys-loop
                     neurotransmitter-gated ion channels (also known as
                     ligand-gated ion channel (LGIC)); cl28912"
                     /db_xref="CDD:475126"
     Site            order(64,66,72..73,80,102,104,113..114,116,118..119,
                     130..132,134,144,146,148,152,174,231)
                     /site_type="other"
                     /note="pentamer interface [polypeptide binding]"
                     /db_xref="CDD:349787"
     CDS             1..449
                     /gene="CHRNB4"
                     /coded_by="XM_017021889.3:78..1427"
                     /db_xref="GeneID:1143"
                     /db_xref="HGNC:HGNC:1964"
                     /db_xref="MIM:118509"
ORIGIN      
        1 mrrapslvlf flvalcgrgn crvanaeekl mddllnktry nnlirpatss sqlisiklql
       61 slaqlisvne reqimttnvw lkqewtdyrl twnssryegv nilripakri wlpdivlynn
      121 adgtyevsvy tnlivrsngs vlwlppaiyk sackievkyf pfdqqnctlk frswtydhte
      181 idmvlmtpta smddftpsge wdivalpgrr tvnpqdpsyv dvtydfiikr kplfytinli
      241 ipcvlttlla ilvfylpsdc gekmtlcisv llaltfflll iskivpptsl dvpligkylm
      301 ftmvlvtfsi vtsvcvlnvh hrspsthtma pwvkrcflhk lptflfmkrp gpdssparaf
      361 ppskscvtkp eatatstsps nfygnsmyfv npasaasksp agstpvaipr dfwlrssgrf
      421 rqdvqealeg vsfiaqhmkn ddedqsslc
//
LOCUS       XP_011519493             424 aa            linear   PRI 05-AUG-2025
DEFINITION  neuronal acetylcholine receptor subunit beta-4 isoform X6 [Homo
            sapiens].
ACCESSION   XP_011519493
VERSION     XP_011519493.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521191.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..424
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..424
                     /product="neuronal acetylcholine receptor subunit beta-4
                     isoform X6"
                     /calculated_mol_wt=47921
     Region          1..157
                     /region_name="LGIC_ECD"
                     /note="extracellular domain (ECD) of Cys-loop
                     neurotransmitter-gated ion channels (also known as
                     ligand-gated ion channel (LGIC)); cl28912"
                     /db_xref="CDD:475126"
     Site            order(6,28,30,39..40,42,44..45,56..58,60,70,72,74,78,100,
                     157)
                     /site_type="other"
                     /note="pentamer interface [polypeptide binding]"
                     /db_xref="CDD:349787"
     Region          165..404
                     /region_name="Neur_chan_memb"
                     /note="Neurotransmitter-gated ion-channel transmembrane
                     region; pfam02932"
                     /db_xref="CDD:460753"
     CDS             1..424
                     /gene="CHRNB4"
                     /coded_by="XM_011521191.3:151..1425"
                     /db_xref="GeneID:1143"
                     /db_xref="HGNC:HGNC:1964"
                     /db_xref="MIM:118509"
ORIGIN      
        1 mttnvwlkqe wtdyrltwns sryegvnilr ipakriwlpd ivlynnadgt yevsvytnli
       61 vrsngsvlwl ppaiyksack ievkyfpfdq qnctlkfrsw tydhteidmv lmtptasmdd
      121 ftpsgewdiv alpgrrtvnp qdpsyvdvty dfiikrkplf ytinliipcv lttllailvf
      181 ylpsdcgekm tlcisvllal tffllliski vpptsldvpl igkylmftmv lvtfsivtsv
      241 cvlnvhhrsp sthtmapwvk rcflhklptf lfmkrpgpds sparafppsk scvtkpeata
      301 tstspsnfyg nsmyfvnpas aaskspagst pvaiprdfwl rssgrfrqdv qealegvsfi
      361 aqhmkndded qsvvedwkyv amvvdrlflw vfmfvcvlgt vglflpplfq thaasegpya
      421 aqrd
//
LOCUS       XP_011519492             424 aa            linear   PRI 05-AUG-2025
DEFINITION  neuronal acetylcholine receptor subunit beta-4 isoform X6 [Homo
            sapiens].
ACCESSION   XP_011519492
VERSION     XP_011519492.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521190.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..424
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..424
                     /product="neuronal acetylcholine receptor subunit beta-4
                     isoform X6"
                     /calculated_mol_wt=47921
     Region          1..157
                     /region_name="LGIC_ECD"
                     /note="extracellular domain (ECD) of Cys-loop
                     neurotransmitter-gated ion channels (also known as
                     ligand-gated ion channel (LGIC)); cl28912"
                     /db_xref="CDD:475126"
     Site            order(6,28,30,39..40,42,44..45,56..58,60,70,72,74,78,100,
                     157)
                     /site_type="other"
                     /note="pentamer interface [polypeptide binding]"
                     /db_xref="CDD:349787"
     Region          165..404
                     /region_name="Neur_chan_memb"
                     /note="Neurotransmitter-gated ion-channel transmembrane
                     region; pfam02932"
                     /db_xref="CDD:460753"
     CDS             1..424
                     /gene="CHRNB4"
                     /coded_by="XM_011521190.3:504..1778"
                     /db_xref="GeneID:1143"
                     /db_xref="HGNC:HGNC:1964"
                     /db_xref="MIM:118509"
ORIGIN      
        1 mttnvwlkqe wtdyrltwns sryegvnilr ipakriwlpd ivlynnadgt yevsvytnli
       61 vrsngsvlwl ppaiyksack ievkyfpfdq qnctlkfrsw tydhteidmv lmtptasmdd
      121 ftpsgewdiv alpgrrtvnp qdpsyvdvty dfiikrkplf ytinliipcv lttllailvf
      181 ylpsdcgekm tlcisvllal tffllliski vpptsldvpl igkylmftmv lvtfsivtsv
      241 cvlnvhhrsp sthtmapwvk rcflhklptf lfmkrpgpds sparafppsk scvtkpeata
      301 tstspsnfyg nsmyfvnpas aaskspagst pvaiprdfwl rssgrfrqdv qealegvsfi
      361 aqhmkndded qsvvedwkyv amvvdrlflw vfmfvcvlgt vglflpplfq thaasegpya
      421 aqrd
//
LOCUS       XP_011519494             316 aa            linear   PRI 05-AUG-2025
DEFINITION  neuronal acetylcholine receptor subunit beta-4 isoform X7 [Homo
            sapiens].
ACCESSION   XP_011519494
VERSION     XP_011519494.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521192.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..316
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..316
                     /product="neuronal acetylcholine receptor subunit beta-4
                     isoform X7"
                     /calculated_mol_wt=35065
     Region          <1..49
                     /region_name="LGIC_ECD"
                     /note="extracellular domain (ECD) of Cys-loop
                     neurotransmitter-gated ion channels (also known as
                     ligand-gated ion channel (LGIC)); cl28912"
                     /db_xref="CDD:475126"
     Region          57..296
                     /region_name="Neur_chan_memb"
                     /note="Neurotransmitter-gated ion-channel transmembrane
                     region; pfam02932"
                     /db_xref="CDD:460753"
     CDS             1..316
                     /gene="CHRNB4"
                     /coded_by="XM_011521192.3:425..1375"
                     /db_xref="GeneID:1143"
                     /db_xref="HGNC:HGNC:1964"
                     /db_xref="MIM:118509"
ORIGIN      
        1 mvlmtptasm ddftpsgewd ivalpgrrtv npqdpsyvdv tydfiikrkp lfytinliip
       61 cvlttllail vfylpsdcge kmtlcisvll altfflllis kivpptsldv pligkylmft
      121 mvlvtfsivt svcvlnvhhr spsthtmapw vkrcflhklp tflfmkrpgp dssparafpp
      181 skscvtkpea tatstspsnf ygnsmyfvnp asaaskspag stpvaiprdf wlrssgrfrq
      241 dvqealegvs fiaqhmkndd edqsvvedwk yvamvvdrlf lwvfmfvcvl gtvglflppl
      301 fqthaasegp yaaqrd
//
LOCUS       XP_011542170            1034 aa            linear   PRI 05-AUG-2025
DEFINITION  gamma-tubulin complex component 5 isoform X1 [Homo sapiens].
ACCESSION   XP_011542170
VERSION     XP_011542170.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011543868.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1034
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1034
                     /product="gamma-tubulin complex component 5 isoform X1"
                     /calculated_mol_wt=119171
     Region          15..108
                     /region_name="GCP5_NTD"
                     /note="N-terminal domain of gamma-tubulin complex
                     component 5 (GCP-5) and similar proteins; cd22572"
                     /db_xref="CDD:439339"
     Region          272..578
                     /region_name="GCP_N_terminal"
                     /note="Gamma tubulin complex component N-terminal;
                     pfam17681"
                     /db_xref="CDD:465456"
     Region          717..1012
                     /region_name="GCP_C_terminal"
                     /note="Gamma tubulin complex component C-terminal;
                     pfam04130"
                     /db_xref="CDD:461187"
     CDS             1..1034
                     /gene="TUBGCP5"
                     /gene_synonym="GCP5"
                     /coded_by="XM_011543868.3:27..3131"
                     /db_xref="GeneID:114791"
                     /db_xref="HGNC:HGNC:18600"
                     /db_xref="MIM:608147"
ORIGIN      
        1 marhgppwsr ldaqqerdvr elvrgvaglq deadpnfqla lnfawsnfrf hrfldvnshk
       61 iektiegiye kfvihsdlsk aaswkrltee flnaplpsik eiktdahysi lslllclsds
      121 psnssyvetp rnkevekkdd fdwgkylmed eemdigpymd tpnwseesee endqqplsre
      181 dsgiqvdrtp leeqdqnrkl dpciswkade pddrswlehh vvhqywtarp sqfphslhlh
      241 snlaavwdqh lyssdplyvp ddrvlvtetq viretlwlls gvkklfifql idgkvtvrnn
      301 iivthlthsc lrsvleqiaa ygqvvfrlqe fidevmghss esmlpgsgsv pkksteapfr
      361 tyqafmwaly kyfisfkeel aeiekciinn dttitlaivv dklaprlsql kvlhkvfstg
      421 vaevppdtrn vvrashllnt lykaileydn vgeaseqtvs llfslwvetv rpylqtvdew
      481 ivhghlwdga refiiqrnkn vpvnhrdfwy atytlysvse kteneekmsd nasassgsdq
      541 gpssrqhtmv sflkpvlkqi imagksmqll knlqcaestt cqagardaer kslytlfles
      601 vqsrlrhged stpqvlteqq atkenlmkmq siaeshleld dvhdpllain farmyleqsd
      661 fhekfaggdv cvdrssesvt cqtfeltlrs clyphidkqy ldccgnlmqt lkkdyrlvey
      721 lqamrnfflm eggdtmydfy tsifdkirek etwqnvsfln vqlqeavgqr ypedssrlsi
      781 sfenvdtakk klpvhildgl tlsykvpwpv divislecqk iynqvfllll qikwakysld
      841 vllfgelvst aekprlkegl iheqdtvaqf gpqkepvrqq ihrmfllrvk lmhfvnslhn
      901 yimtrilhst glefqhqvee akdldqliki hyrylstihd rcllrekvsf vkeaimkvln
      961 lalmfadgwq aglgtwrmes iekmesdfkn chmflvtiln kavcrgsfph fsiglpvvci
     1021 rrwsllstgg lggt
//
LOCUS       XP_011542172            1031 aa            linear   PRI 05-AUG-2025
DEFINITION  gamma-tubulin complex component 5 isoform X2 [Homo sapiens].
ACCESSION   XP_011542172
VERSION     XP_011542172.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011543870.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1031
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1031
                     /product="gamma-tubulin complex component 5 isoform X2"
                     /calculated_mol_wt=118953
     Region          15..108
                     /region_name="GCP5_NTD"
                     /note="N-terminal domain of gamma-tubulin complex
                     component 5 (GCP-5) and similar proteins; cd22572"
                     /db_xref="CDD:439339"
     Region          272..578
                     /region_name="GCP_N_terminal"
                     /note="Gamma tubulin complex component N-terminal;
                     pfam17681"
                     /db_xref="CDD:465456"
     Region          717..1000
                     /region_name="GCP_C_terminal"
                     /note="Gamma tubulin complex component C-terminal;
                     pfam04130"
                     /db_xref="CDD:461187"
     CDS             1..1031
                     /gene="TUBGCP5"
                     /gene_synonym="GCP5"
                     /coded_by="XM_011543870.3:27..3122"
                     /db_xref="GeneID:114791"
                     /db_xref="HGNC:HGNC:18600"
                     /db_xref="MIM:608147"
ORIGIN      
        1 marhgppwsr ldaqqerdvr elvrgvaglq deadpnfqla lnfawsnfrf hrfldvnshk
       61 iektiegiye kfvihsdlsk aaswkrltee flnaplpsik eiktdahysi lslllclsds
      121 psnssyvetp rnkevekkdd fdwgkylmed eemdigpymd tpnwseesee endqqplsre
      181 dsgiqvdrtp leeqdqnrkl dpciswkade pddrswlehh vvhqywtarp sqfphslhlh
      241 snlaavwdqh lyssdplyvp ddrvlvtetq viretlwlls gvkklfifql idgkvtvrnn
      301 iivthlthsc lrsvleqiaa ygqvvfrlqe fidevmghss esmlpgsgsv pkksteapfr
      361 tyqafmwaly kyfisfkeel aeiekciinn dttitlaivv dklaprlsql kvlhkvfstg
      421 vaevppdtrn vvrashllnt lykaileydn vgeaseqtvs llfslwvetv rpylqtvdew
      481 ivhghlwdga refiiqrnkn vpvnhrdfwy atytlysvse kteneekmsd nasassgsdq
      541 gpssrqhtmv sflkpvlkqi imagksmqll knlqcaestt cqagardaer kslytlfles
      601 vqsrlrhged stpqvlteqq atkenlmkmq siaeshleld dvhdpllain farmyleqsd
      661 fhekfaggdv cvdrssesvt cqtfeltlrs clyphidkqy ldccgnlmqt lkkdyrlvey
      721 lqamrnfflm eggdtmydfy tsifdkirek etwqnvsfln vqlqeavgqr ypedssrlsi
      781 sfenvdtakk klpvhildgl tlsykvpwpv divislecqk iynqvfllll qikwakysld
      841 vllfgelvst aekprlkegl iheqdtvaqf gpqkepvrqq ihrmfllrvk lmhfvnslhn
      901 yimtrilhst glefqhqvee akdldqliki hyrylstihd rcllrekvsf vkeaimkvln
      961 lalmfadgwq aglgtwrmes iekmesdfkn chmflvtiln kavcrgsfph wlpvvcirrw
     1021 sllstgglgg t
//
LOCUS       XP_047288086             914 aa            linear   PRI 05-AUG-2025
DEFINITION  gamma-tubulin complex component 5 isoform X3 [Homo sapiens].
ACCESSION   XP_047288086
VERSION     XP_047288086.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432130.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..914
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..914
                     /product="gamma-tubulin complex component 5 isoform X3"
                     /calculated_mol_wt=105380
     Region          125..431
                     /region_name="GCP_N_terminal"
                     /note="Gamma tubulin complex component N-terminal;
                     pfam17681"
                     /db_xref="CDD:465456"
     Region          570..853
                     /region_name="GCP_C_terminal"
                     /note="Gamma tubulin complex component C-terminal;
                     pfam04130"
                     /db_xref="CDD:461187"
     CDS             1..914
                     /gene="TUBGCP5"
                     /gene_synonym="GCP5"
                     /coded_by="XM_047432130.1:491..3235"
                     /db_xref="GeneID:114791"
                     /db_xref="HGNC:HGNC:18600"
                     /db_xref="MIM:608147"
ORIGIN      
        1 medeemdigp ymdtpnwsee seeendqqpl sredsgiqvd rtpleeqdqn rkldpciswk
       61 adepddrswl ehhvvhqywt arpsqfphsl hlhsnlaavw dqhlyssdpl yvpddrvlvt
      121 etqviretlw llsgvkklfi fqlidgkvtv rnniivthlt hsclrsvleq iaaygqvvfr
      181 lqefidevmg hssesmlpgs gsvpkkstea pfrtyqafmw alykyfisfk eelaeiekci
      241 inndttitla ivvdklaprl sqlkvlhkvf stgvaevppd trnvvrashl lntlykaile
      301 ydnvgeaseq tvsllfslwv etvrpylqtv dewivhghlw dgarefiiqr nknvpvnhrd
      361 fwyatytlys vsekteneek msdnasassg sdqgpssrqh tmvsflkpvl kqiimagksm
      421 qllknlqcae sttcqagard aerkslytlf lesvqsrlrh gedstpqvlt eqqatkenlm
      481 kmqsiaeshl elddvhdpll ainfarmyle qsdfhekfag gdvcvdrsse svtcqtfelt
      541 lrsclyphid kqyldccgnl mqtlkkdyrl veylqamrnf flmeggdtmy dfytsifdki
      601 reketwqnvs flnvqlqeav gqrypedssr lsisfenvdt akkklpvhil dgltlsykvp
      661 wpvdivisle cqkiynqvfl lllqikwaky sldvllfgel vstaekprlk egliheqdtv
      721 aqfgpqkepv rqqihrmfll rvklmhfvns lhnyimtril hstglefqhq veeakdldql
      781 ikihyrylst ihdrcllrek vsfvkeaimk vlnlalmfad gwqaglgtwr mesiekmesd
      841 fknchmflvt ilnkavcrgs fphygislce shsiaqagvq whnlsslqpl ppelkqsahl
      901 dlpkcwdyrp vctl
//
LOCUS       XP_016877383             914 aa            linear   PRI 05-AUG-2025
DEFINITION  gamma-tubulin complex component 5 isoform X3 [Homo sapiens].
ACCESSION   XP_016877383
VERSION     XP_016877383.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021894.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..914
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..914
                     /product="gamma-tubulin complex component 5 isoform X3"
                     /calculated_mol_wt=105380
     Region          125..431
                     /region_name="GCP_N_terminal"
                     /note="Gamma tubulin complex component N-terminal;
                     pfam17681"
                     /db_xref="CDD:465456"
     Region          570..853
                     /region_name="GCP_C_terminal"
                     /note="Gamma tubulin complex component C-terminal;
                     pfam04130"
                     /db_xref="CDD:461187"
     CDS             1..914
                     /gene="TUBGCP5"
                     /gene_synonym="GCP5"
                     /coded_by="XM_017021894.2:124..2868"
                     /db_xref="GeneID:114791"
                     /db_xref="HGNC:HGNC:18600"
                     /db_xref="MIM:608147"
ORIGIN      
        1 medeemdigp ymdtpnwsee seeendqqpl sredsgiqvd rtpleeqdqn rkldpciswk
       61 adepddrswl ehhvvhqywt arpsqfphsl hlhsnlaavw dqhlyssdpl yvpddrvlvt
      121 etqviretlw llsgvkklfi fqlidgkvtv rnniivthlt hsclrsvleq iaaygqvvfr
      181 lqefidevmg hssesmlpgs gsvpkkstea pfrtyqafmw alykyfisfk eelaeiekci
      241 inndttitla ivvdklaprl sqlkvlhkvf stgvaevppd trnvvrashl lntlykaile
      301 ydnvgeaseq tvsllfslwv etvrpylqtv dewivhghlw dgarefiiqr nknvpvnhrd
      361 fwyatytlys vsekteneek msdnasassg sdqgpssrqh tmvsflkpvl kqiimagksm
      421 qllknlqcae sttcqagard aerkslytlf lesvqsrlrh gedstpqvlt eqqatkenlm
      481 kmqsiaeshl elddvhdpll ainfarmyle qsdfhekfag gdvcvdrsse svtcqtfelt
      541 lrsclyphid kqyldccgnl mqtlkkdyrl veylqamrnf flmeggdtmy dfytsifdki
      601 reketwqnvs flnvqlqeav gqrypedssr lsisfenvdt akkklpvhil dgltlsykvp
      661 wpvdivisle cqkiynqvfl lllqikwaky sldvllfgel vstaekprlk egliheqdtv
      721 aqfgpqkepv rqqihrmfll rvklmhfvns lhnyimtril hstglefqhq veeakdldql
      781 ikihyrylst ihdrcllrek vsfvkeaimk vlnlalmfad gwqaglgtwr mesiekmesd
      841 fknchmflvt ilnkavcrgs fphygislce shsiaqagvq whnlsslqpl ppelkqsahl
      901 dlpkcwdyrp vctl
//
LOCUS       XP_016877384             913 aa            linear   PRI 05-AUG-2025
DEFINITION  gamma-tubulin complex component 5 isoform X4 [Homo sapiens].
ACCESSION   XP_016877384
VERSION     XP_016877384.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021895.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..913
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..913
                     /product="gamma-tubulin complex component 5 isoform X4"
                     /calculated_mol_wt=105309
     Region          124..430
                     /region_name="GCP_N_terminal"
                     /note="Gamma tubulin complex component N-terminal;
                     pfam17681"
                     /db_xref="CDD:465456"
     Region          569..852
                     /region_name="GCP_C_terminal"
                     /note="Gamma tubulin complex component C-terminal;
                     pfam04130"
                     /db_xref="CDD:461187"
     CDS             1..913
                     /gene="TUBGCP5"
                     /gene_synonym="GCP5"
                     /coded_by="XM_017021895.2:488..3229"
                     /db_xref="GeneID:114791"
                     /db_xref="HGNC:HGNC:18600"
                     /db_xref="MIM:608147"
ORIGIN      
        1 medeemdigp ymdtpnwsee seeendqqpl sredsgiqvd rtpleeqdqn rkldpciswk
       61 depddrswle hhvvhqywta rpsqfphslh lhsnlaavwd qhlyssdply vpddrvlvte
      121 tqviretlwl lsgvkklfif qlidgkvtvr nniivthlth sclrsvleqi aaygqvvfrl
      181 qefidevmgh ssesmlpgsg svpkksteap frtyqafmwa lykyfisfke elaeiekcii
      241 nndttitlai vvdklaprls qlkvlhkvfs tgvaevppdt rnvvrashll ntlykailey
      301 dnvgeaseqt vsllfslwve tvrpylqtvd ewivhghlwd garefiiqrn knvpvnhrdf
      361 wyatytlysv sekteneekm sdnasassgs dqgpssrqht mvsflkpvlk qiimagksmq
      421 llknlqcaes ttcqagarda erkslytlfl esvqsrlrhg edstpqvlte qqatkenlmk
      481 mqsiaeshle lddvhdplla infarmyleq sdfhekfagg dvcvdrsses vtcqtfeltl
      541 rsclyphidk qyldccgnlm qtlkkdyrlv eylqamrnff lmeggdtmyd fytsifdkir
      601 eketwqnvsf lnvqlqeavg qrypedssrl sisfenvdta kkklpvhild gltlsykvpw
      661 pvdivislec qkiynqvfll llqikwakys ldvllfgelv staekprlke gliheqdtva
      721 qfgpqkepvr qqihrmfllr vklmhfvnsl hnyimtrilh stglefqhqv eeakdldqli
      781 kihyrylsti hdrcllrekv sfvkeaimkv lnlalmfadg wqaglgtwrm esiekmesdf
      841 knchmflvti lnkavcrgsf phygislces hsiaqagvqw hnlsslqplp pelkqsahld
      901 lpkcwdyrpv ctl
//
LOCUS       XP_047288087             878 aa            linear   PRI 05-AUG-2025
DEFINITION  gamma-tubulin complex component 5 isoform X5 [Homo sapiens].
ACCESSION   XP_047288087
VERSION     XP_047288087.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432131.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..878
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..878
                     /product="gamma-tubulin complex component 5 isoform X5"
                     /calculated_mol_wt=101228
     Region          125..431
                     /region_name="GCP_N_terminal"
                     /note="Gamma tubulin complex component N-terminal;
                     pfam17681"
                     /db_xref="CDD:465456"
     Region          570..871
                     /region_name="GCP_C_terminal"
                     /note="Gamma tubulin complex component C-terminal;
                     pfam04130"
                     /db_xref="CDD:461187"
     CDS             1..878
                     /gene="TUBGCP5"
                     /gene_synonym="GCP5"
                     /coded_by="XM_047432131.1:486..3122"
                     /db_xref="GeneID:114791"
                     /db_xref="HGNC:HGNC:18600"
                     /db_xref="MIM:608147"
ORIGIN      
        1 medeemdigp ymdtpnwsee seeendqqpl sredsgiqvd rtpleeqdqn rkldpciswk
       61 adepddrswl ehhvvhqywt arpsqfphsl hlhsnlaavw dqhlyssdpl yvpddrvlvt
      121 etqviretlw llsgvkklfi fqlidgkvtv rnniivthlt hsclrsvleq iaaygqvvfr
      181 lqefidevmg hssesmlpgs gsvpkkstea pfrtyqafmw alykyfisfk eelaeiekci
      241 inndttitla ivvdklaprl sqlkvlhkvf stgvaevppd trnvvrashl lntlykaile
      301 ydnvgeaseq tvsllfslwv etvrpylqtv dewivhghlw dgarefiiqr nknvpvnhrd
      361 fwyatytlys vsekteneek msdnasassg sdqgpssrqh tmvsflkpvl kqiimagksm
      421 qllknlqcae sttcqagard aerkslytlf lesvqsrlrh gedstpqvlt eqqatkenlm
      481 kmqsiaeshl elddvhdpll ainfarmyle qsdfhekfag gdvcvdrsse svtcqtfelt
      541 lrsclyphid kqyldccgnl mqtlkkdyrl veylqamrnf flmeggdtmy dfytsifdki
      601 reketwqnvs flnvqlqeav gqrypedssr lsisfenvdt akkklpvhil dgltlsykvp
      661 wpvdivisle cqkiynqvfl lllqikwaky sldvllfgel vstaekprlk egliheqdtv
      721 aqfgpqkepv rqqihrmfll rvklmhfvns lhnyimtril hstglefqhq veeakdldql
      781 ikihyrylst ihdrcllrek vsfvkeaimk vlnlalmfad gwqaglgtwr mesiekmesd
      841 fknchmflvt ilnkavcrgs fphleslals lmagmeqs
//
LOCUS       XP_016877385             754 aa            linear   PRI 05-AUG-2025
DEFINITION  gamma-tubulin complex component 5 isoform X6 [Homo sapiens].
ACCESSION   XP_016877385
VERSION     XP_016877385.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021896.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..754
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..754
                     /product="gamma-tubulin complex component 5 isoform X6"
                     /calculated_mol_wt=86590
     Region          3..271
                     /region_name="GCP_N_terminal"
                     /note="Gamma tubulin complex component N-terminal;
                     pfam17681"
                     /db_xref="CDD:465456"
     Region          410..693
                     /region_name="GCP_C_terminal"
                     /note="Gamma tubulin complex component C-terminal;
                     pfam04130"
                     /db_xref="CDD:461187"
     CDS             1..754
                     /gene="TUBGCP5"
                     /gene_synonym="GCP5"
                     /coded_by="XM_017021896.2:88..2352"
                     /db_xref="GeneID:114791"
                     /db_xref="HGNC:HGNC:18600"
                     /db_xref="MIM:608147"
ORIGIN      
        1 msclrsvleq iaaygqvvfr lqefidevmg hssesmlpgs gsvpkkstea pfrtyqafmw
       61 alykyfisfk eelaeiekci inndttitla ivvdklaprl sqlkvlhkvf stgvaevppd
      121 trnvvrashl lntlykaile ydnvgeaseq tvsllfslwv etvrpylqtv dewivhghlw
      181 dgarefiiqr nknvpvnhrd fwyatytlys vsekteneek msdnasassg sdqgpssrqh
      241 tmvsflkpvl kqiimagksm qllknlqcae sttcqagard aerkslytlf lesvqsrlrh
      301 gedstpqvlt eqqatkenlm kmqsiaeshl elddvhdpll ainfarmyle qsdfhekfag
      361 gdvcvdrsse svtcqtfelt lrsclyphid kqyldccgnl mqtlkkdyrl veylqamrnf
      421 flmeggdtmy dfytsifdki reketwqnvs flnvqlqeav gqrypedssr lsisfenvdt
      481 akkklpvhil dgltlsykvp wpvdivisle cqkiynqvfl lllqikwaky sldvllfgel
      541 vstaekprlk egliheqdtv aqfgpqkepv rqqihrmfll rvklmhfvns lhnyimtril
      601 hstglefqhq veeakdldql ikihyrylst ihdrcllrek vsfvkeaimk vlnlalmfad
      661 gwqaglgtwr mesiekmesd fknchmflvt ilnkavcrgs fphygislce shsiaqagvq
      721 whnlsslqpl ppelkqsahl dlpkcwdyrp vctl
//
LOCUS       XP_016877390             647 aa            linear   PRI 05-AUG-2025
DEFINITION  gamma-tubulin complex component 5 isoform X7 [Homo sapiens].
ACCESSION   XP_016877390
VERSION     XP_016877390.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021901.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..647
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..647
                     /product="gamma-tubulin complex component 5 isoform X7"
                     /calculated_mol_wt=74468
     Region          <40..164
                     /region_name="GCP_N_terminal"
                     /note="Gamma tubulin complex component N-terminal;
                     pfam17681"
                     /db_xref="CDD:465456"
     Region          303..586
                     /region_name="GCP_C_terminal"
                     /note="Gamma tubulin complex component C-terminal;
                     pfam04130"
                     /db_xref="CDD:461187"
     CDS             1..647
                     /gene="TUBGCP5"
                     /gene_synonym="GCP5"
                     /coded_by="XM_017021901.2:118..2061"
                     /db_xref="GeneID:114791"
                     /db_xref="HGNC:HGNC:18600"
                     /db_xref="MIM:608147"
ORIGIN      
        1 mssgpltclt pctrpflnmt mlekplskpd qgtlradrah slpqvsllfs lwvetvrpyl
       61 qtvdewivhg hlwdgarefi iqrnknvpvn hrdfwyatyt lysvsekten eekmsdnasa
      121 ssgsdqgpss rqhtmvsflk pvlkqiimag ksmqllknlq caesttcqag ardaerksly
      181 tlflesvqsr lrhgedstpq vlteqqatke nlmkmqsiae shlelddvhd pllainfarm
      241 yleqsdfhek faggdvcvdr ssesvtcqtf eltlrsclyp hidkqyldcc gnlmqtlkkd
      301 yrlveylqam rnfflmeggd tmydfytsif dkireketwq nvsflnvqlq eavgqryped
      361 ssrlsisfen vdtakkklpv hildgltlsy kvpwpvdivi slecqkiynq vfllllqikw
      421 akysldvllf gelvstaekp rlkegliheq dtvaqfgpqk epvrqqihrm fllrvklmhf
      481 vnslhnyimt rilhstglef qhqveeakdl dqlikihyry lstihdrcll rekvsfvkea
      541 imkvlnlalm fadgwqaglg twrmesiekm esdfknchmf lvtilnkavc rgsfphygis
      601 lceshsiaqa gvqwhnlssl qplppelkqs ahldlpkcwd yrpvctl
//
LOCUS       XP_005254203             848 aa            linear   PRI 05-AUG-2025
DEFINITION  DIS3-like exonuclease 1 isoform X1 [Homo sapiens].
ACCESSION   XP_005254203
VERSION     XP_005254203.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254146.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..848
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..848
                     /product="DIS3-like exonuclease 1 isoform X1"
                     /calculated_mol_wt=97329
     Region          11..188
                     /region_name="PIN_Rrp44-like"
                     /note="VapC-like PIN domain of yeast exosome subunit Rrp44
                     endoribonuclease and other eukaryotic homologs; cd09862"
                     /db_xref="CDD:350211"
     Site            order(22..26,28,30,88,92..93,100,104,118,121)
                     /site_type="other"
                     /note="exosome subunit interface [polypeptide binding]"
                     /db_xref="CDD:350211"
     Site            order(33,38,41,153)
                     /site_type="metal-binding"
                     /note="metal binding site [ion binding]"
                     /db_xref="CDD:350211"
     Region          238..843
                     /region_name="VacB"
                     /note="Exoribonuclease R [Transcription]; COG0557"
                     /db_xref="CDD:440323"
     CDS             1..848
                     /gene="DIS3L"
                     /gene_synonym="DIS3L1"
                     /coded_by="XM_005254146.5:30..2576"
                     /db_xref="GeneID:115752"
                     /db_xref="HGNC:HGNC:28698"
                     /db_xref="MIM:614183"
ORIGIN      
        1 mlqkrekvll lrtfqgrtlr ivrehylrpc vpchsplcpq paacshdgkl lssdvthyvi
       61 pdwkvvqdyl eilefpelkg iifmqtacqa vqhqrgrrqy nklrnllkda rhdcilfane
      121 fqqccylpre rgesmekwqt rsiynaavwy yhhcqdrmpi vmvtedeeai qqygsetegv
      181 fvitfknyld nfwpdlkaah elcdsilqsr rerenesqes hgkeypehlp levleagiks
      241 gryiqgilnv nkhraqieaf vrlqgasskd sdlvsdilih gmkarnrsih gdvvvvellp
      301 knewkgrtva lcendcddka sgespsepmp tgrvvgilqk nwrdyvvtfp skeevqsqgk
      361 naqkilvtpw dyripkiris tqqaetlqdf rvvvridswe stsvypnghf vrvlgrigdl
      421 egeiatilve nsisvipfse aqmcempvnt pespwkvspe eeqkrkdlrk shlvfsidpk
      481 gcedvddtls vrtlnngnle lgvhiadvth fvapnsyidi eartrattyy ladrrydmlp
      541 svlsadlcsl lggvdryavs imweldkasy eikkvwygrt iirsayklfy eaaqelldgn
      601 lsvvddipef kdldeksrqa kleelvwaig kltdiarhvr akrdgcgale legvevcvql
      661 ddkknihdli pkqplevhet vaecmilanh wvakkiwesf phqallrqhp pphqeffsel
      721 recakakgff idtrsnktla dsldnandph dpivnrllrs matqamsnal yfstgscaee
      781 efhhyglald kythftspir rysdivvhrl lmaaiskdkk meikgnlfsn kdleelcrhi
      841 nnrnqvem
//
LOCUS       XP_011519496             448 aa            linear   PRI 05-AUG-2025
DEFINITION  creatine kinase U-type, mitochondrial isoform X1 [Homo sapiens].
ACCESSION   XP_011519496
VERSION     XP_011519496.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521194.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..448
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..448
                     /product="creatine kinase U-type, mitochondrial isoform
                     X1"
                     /calculated_mol_wt=50290
     Region          80..437
                     /region_name="creatine_kinase_like"
                     /note="Phosphagen (guanidino) kinases such as creatine
                     kinase and similar enzymes; cd00716"
                     /db_xref="CDD:153076"
     Site            order(136,265,296,347,349)
                     /site_type="other"
                     /note="creatine binding site [chemical binding]"
                     /db_xref="CDD:153076"
     Site            order(192,194,196,255,292,300,356,358..360,384,386,
                     388..389,399)
                     /site_type="other"
                     /note="ADP binding site [chemical binding]"
                     /db_xref="CDD:153076"
     Site            order(381..390,393..402)
                     /site_type="active"
                     /note="substrate specificity loop [active]"
                     /db_xref="CDD:153076"
     CDS             1..448
                     /gene="CKMT1B"
                     /gene_synonym="CKMT; CKMT1; UMTCK"
                     /coded_by="XM_011521194.2:590..1936"
                     /db_xref="GeneID:1159"
                     /db_xref="HGNC:HGNC:1995"
                     /db_xref="MIM:123290"
ORIGIN      
        1 magpfsrlls arpglrllal agagslaagf llrpepvraa serrrlypps qtwptgqlpg
       61 nctrsrrlcp psmvtgyplp saeypdlrkh nncmashltp avyarlcdkt tptgwtldqc
      121 iqtgvdnpgh pfiktvgmva gdeetyevfa dlfdpviqer hngydprtmk httdldaski
      181 rsgyfderyv lssrvrtgrs irglslppac traerrever vvvdalsglk gdlagryyrl
      241 semteaeqqq liddhflfdk pvsplltaag mardwpdarg iwhnneksfl iwvneedhtr
      301 vismekggnm krvferfcrg lkeverliqe rgwefmwner lgyiltcpsn lgtglragvh
      361 iklpllskds rfpkilenlr lqkrgtggvd taatggvfdi snldrlgkse velvqlvidg
      421 vnylidcerr lergqdirip tpvihtkh
//
LOCUS       XP_011519497             448 aa            linear   PRI 05-AUG-2025
DEFINITION  creatine kinase U-type, mitochondrial isoform X1 [Homo sapiens].
ACCESSION   XP_011519497
VERSION     XP_011519497.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521195.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..448
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..448
                     /product="creatine kinase U-type, mitochondrial isoform
                     X1"
                     /calculated_mol_wt=50290
     Region          80..437
                     /region_name="creatine_kinase_like"
                     /note="Phosphagen (guanidino) kinases such as creatine
                     kinase and similar enzymes; cd00716"
                     /db_xref="CDD:153076"
     Site            order(136,265,296,347,349)
                     /site_type="other"
                     /note="creatine binding site [chemical binding]"
                     /db_xref="CDD:153076"
     Site            order(192,194,196,255,292,300,356,358..360,384,386,
                     388..389,399)
                     /site_type="other"
                     /note="ADP binding site [chemical binding]"
                     /db_xref="CDD:153076"
     Site            order(381..390,393..402)
                     /site_type="active"
                     /note="substrate specificity loop [active]"
                     /db_xref="CDD:153076"
     CDS             1..448
                     /gene="CKMT1B"
                     /gene_synonym="CKMT; CKMT1; UMTCK"
                     /coded_by="XM_011521195.3:527..1873"
                     /db_xref="GeneID:1159"
                     /db_xref="HGNC:HGNC:1995"
                     /db_xref="MIM:123290"
ORIGIN      
        1 magpfsrlls arpglrllal agagslaagf llrpepvraa serrrlypps qtwptgqlpg
       61 nctrsrrlcp psmvtgyplp saeypdlrkh nncmashltp avyarlcdkt tptgwtldqc
      121 iqtgvdnpgh pfiktvgmva gdeetyevfa dlfdpviqer hngydprtmk httdldaski
      181 rsgyfderyv lssrvrtgrs irglslppac traerrever vvvdalsglk gdlagryyrl
      241 semteaeqqq liddhflfdk pvsplltaag mardwpdarg iwhnneksfl iwvneedhtr
      301 vismekggnm krvferfcrg lkeverliqe rgwefmwner lgyiltcpsn lgtglragvh
      361 iklpllskds rfpkilenlr lqkrgtggvd taatggvfdi snldrlgkse velvqlvidg
      421 vnylidcerr lergqdirip tpvihtkh
//
LOCUS       XP_011519498             448 aa            linear   PRI 05-AUG-2025
DEFINITION  creatine kinase U-type, mitochondrial isoform X1 [Homo sapiens].
ACCESSION   XP_011519498
VERSION     XP_011519498.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521196.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..448
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..448
                     /product="creatine kinase U-type, mitochondrial isoform
                     X1"
                     /calculated_mol_wt=50290
     Region          80..437
                     /region_name="creatine_kinase_like"
                     /note="Phosphagen (guanidino) kinases such as creatine
                     kinase and similar enzymes; cd00716"
                     /db_xref="CDD:153076"
     Site            order(136,265,296,347,349)
                     /site_type="other"
                     /note="creatine binding site [chemical binding]"
                     /db_xref="CDD:153076"
     Site            order(192,194,196,255,292,300,356,358..360,384,386,
                     388..389,399)
                     /site_type="other"
                     /note="ADP binding site [chemical binding]"
                     /db_xref="CDD:153076"
     Site            order(381..390,393..402)
                     /site_type="active"
                     /note="substrate specificity loop [active]"
                     /db_xref="CDD:153076"
     CDS             1..448
                     /gene="CKMT1B"
                     /gene_synonym="CKMT; CKMT1; UMTCK"
                     /coded_by="XM_011521196.2:452..1798"
                     /db_xref="GeneID:1159"
                     /db_xref="HGNC:HGNC:1995"
                     /db_xref="MIM:123290"
ORIGIN      
        1 magpfsrlls arpglrllal agagslaagf llrpepvraa serrrlypps qtwptgqlpg
       61 nctrsrrlcp psmvtgyplp saeypdlrkh nncmashltp avyarlcdkt tptgwtldqc
      121 iqtgvdnpgh pfiktvgmva gdeetyevfa dlfdpviqer hngydprtmk httdldaski
      181 rsgyfderyv lssrvrtgrs irglslppac traerrever vvvdalsglk gdlagryyrl
      241 semteaeqqq liddhflfdk pvsplltaag mardwpdarg iwhnneksfl iwvneedhtr
      301 vismekggnm krvferfcrg lkeverliqe rgwefmwner lgyiltcpsn lgtglragvh
      361 iklpllskds rfpkilenlr lqkrgtggvd taatggvfdi snldrlgkse velvqlvidg
      421 vnylidcerr lergqdirip tpvihtkh
//
LOCUS       XP_047288088             417 aa            linear   PRI 05-AUG-2025
DEFINITION  creatine kinase U-type, mitochondrial isoform X2 [Homo sapiens].
ACCESSION   XP_047288088
VERSION     XP_047288088.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432132.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..417
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..417
                     /product="creatine kinase U-type, mitochondrial isoform
                     X2"
                     /calculated_mol_wt=46906
     Region          49..406
                     /region_name="creatine_kinase_like"
                     /note="Phosphagen (guanidino) kinases such as creatine
                     kinase and similar enzymes; cd00716"
                     /db_xref="CDD:153076"
     Site            order(105,234,265,316,318)
                     /site_type="other"
                     /note="creatine binding site [chemical binding]"
                     /db_xref="CDD:153076"
     Site            order(161,163,165,224,261,269,325,327..329,353,355,
                     357..358,368)
                     /site_type="other"
                     /note="ADP binding site [chemical binding]"
                     /db_xref="CDD:153076"
     Site            order(350..359,362..371)
                     /site_type="active"
                     /note="substrate specificity loop [active]"
                     /db_xref="CDD:153076"
     CDS             1..417
                     /gene="CKMT1B"
                     /gene_synonym="CKMT; CKMT1; UMTCK"
                     /coded_by="XM_047432132.1:527..1780"
                     /db_xref="GeneID:1159"
                     /db_xref="HGNC:HGNC:1995"
                     /db_xref="MIM:123290"
ORIGIN      
        1 magpfsrlls arpglrllal agagslaagf llrpepvraa serrrlypps aeypdlrkhn
       61 ncmashltpa vyarlcdktt ptgwtldqci qtgvdnpghp fiktvgmvag deetyevfad
      121 lfdpviqerh ngydprtmkh ttdldaskir sgyfderyvl ssrvrtgrsi rglslppact
      181 raerreverv vvdalsglkg dlagryyrls emteaeqqql iddhflfdkp vsplltaagm
      241 ardwpdargi whnneksfli wvneedhtrv ismekggnmk rvferfcrgl keverliqer
      301 gwefmwnerl gyiltcpsnl gtglragvhi klpllskdsr fpkilenlrl qkrgtggvdt
      361 aatggvfdis nldrlgksev elvqlvidgv nylidcerrl ergqdiript pvihtkh
//
LOCUS       XP_047288089             417 aa            linear   PRI 05-AUG-2025
DEFINITION  creatine kinase U-type, mitochondrial isoform X2 [Homo sapiens].
ACCESSION   XP_047288089
VERSION     XP_047288089.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432133.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..417
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..417
                     /product="creatine kinase U-type, mitochondrial isoform
                     X2"
                     /calculated_mol_wt=46906
     Region          49..406
                     /region_name="creatine_kinase_like"
                     /note="Phosphagen (guanidino) kinases such as creatine
                     kinase and similar enzymes; cd00716"
                     /db_xref="CDD:153076"
     Site            order(105,234,265,316,318)
                     /site_type="other"
                     /note="creatine binding site [chemical binding]"
                     /db_xref="CDD:153076"
     Site            order(161,163,165,224,261,269,325,327..329,353,355,
                     357..358,368)
                     /site_type="other"
                     /note="ADP binding site [chemical binding]"
                     /db_xref="CDD:153076"
     Site            order(350..359,362..371)
                     /site_type="active"
                     /note="substrate specificity loop [active]"
                     /db_xref="CDD:153076"
     CDS             1..417
                     /gene="CKMT1B"
                     /gene_synonym="CKMT; CKMT1; UMTCK"
                     /coded_by="XM_047432133.1:452..1705"
                     /db_xref="GeneID:1159"
                     /db_xref="HGNC:HGNC:1995"
                     /db_xref="MIM:123290"
ORIGIN      
        1 magpfsrlls arpglrllal agagslaagf llrpepvraa serrrlypps aeypdlrkhn
       61 ncmashltpa vyarlcdktt ptgwtldqci qtgvdnpghp fiktvgmvag deetyevfad
      121 lfdpviqerh ngydprtmkh ttdldaskir sgyfderyvl ssrvrtgrsi rglslppact
      181 raerreverv vvdalsglkg dlagryyrls emteaeqqql iddhflfdkp vsplltaagm
      241 ardwpdargi whnneksfli wvneedhtrv ismekggnmk rvferfcrgl keverliqer
      301 gwefmwnerl gyiltcpsnl gtglragvhi klpllskdsr fpkilenlrl qkrgtggvdt
      361 aatggvfdis nldrlgksev elvqlvidgv nylidcerrl ergqdiript pvihtkh
//
LOCUS       XP_005254207             258 aa            linear   PRI 05-AUG-2025
DEFINITION  creatine kinase U-type, mitochondrial isoform X3 [Homo sapiens].
ACCESSION   XP_005254207
VERSION     XP_005254207.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254150.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..258
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..258
                     /product="creatine kinase U-type, mitochondrial isoform
                     X3"
                     /calculated_mol_wt=29270
     Region          <4..247
                     /region_name="phosphagen_kinases"
                     /note="Phosphagen (guanidino) kinases; cl02823"
                     /db_xref="CDD:470681"
     Site            order(4,6,65,102,110,166,168..170,194,196,209)
                     /site_type="other"
                     /note="ADP binding site [chemical binding]"
                     /db_xref="CDD:153057"
     Site            order(106,157,159)
                     /site_type="active"
                     /note="phosphagen binding site [active]"
                     /db_xref="CDD:153057"
     Site            order(191..196,207..212)
                     /site_type="active"
                     /note="substrate specificity loop [active]"
                     /db_xref="CDD:153057"
     CDS             1..258
                     /gene="CKMT1B"
                     /gene_synonym="CKMT; CKMT1; UMTCK"
                     /coded_by="XM_005254150.5:81..857"
                     /db_xref="GeneID:1159"
                     /db_xref="HGNC:HGNC:1995"
                     /db_xref="MIM:123290"
ORIGIN      
        1 mpvkvrtgrs irglslppac traerrever vvvdalsglk gdlagryyrl semteaeqqq
       61 liddhflfdk pvsplltaag mardwpdarg iwhnneksfl iwvneedhtr vismekggnm
      121 krvferfcrg lkeverliqe rgwefmwner lgyiltcpsn lgtglragvh iklpllskds
      181 rfpkilenlr lqkrgtggvd taatggvfdi snldrlgkse velvqlvidg vnylidcerr
      241 lergqdirip tpvihtkh
//
LOCUS       XP_047288090             216 aa            linear   PRI 05-AUG-2025
DEFINITION  creatine kinase U-type, mitochondrial isoform X4 [Homo sapiens].
ACCESSION   XP_047288090
VERSION     XP_047288090.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432134.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..216
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..216
                     /product="creatine kinase U-type, mitochondrial isoform
                     X4"
                     /calculated_mol_wt=23473
     Region          80..>203
                     /region_name="phosphagen_kinases"
                     /note="Phosphagen (guanidino) kinases; cl02823"
                     /db_xref="CDD:470681"
     CDS             1..216
                     /gene="CKMT1B"
                     /gene_synonym="CKMT; CKMT1; UMTCK"
                     /coded_by="XM_047432134.1:590..1240"
                     /db_xref="GeneID:1159"
                     /db_xref="HGNC:HGNC:1995"
                     /db_xref="MIM:123290"
ORIGIN      
        1 magpfsrlls arpglrllal agagslaagf llrpepvraa serrrlypps qtwptgqlpg
       61 nctrsrrlcp psmvtgyplp saeypdlrkh nncmashltp avyarlcdkt tptgwtldqc
      121 iqtgvdnpgh pfiktvgmva gdeetyevfa dlfdpviqer hngydprtmk httdldasks
      181 qnwpkhprtq sasslhssra trggtccggc tewpeg
//
LOCUS       XP_016877392             711 aa            linear   PRI 05-AUG-2025
DEFINITION  protein-glutamine gamma-glutamyltransferase Z isoform X1 [Homo
            sapiens].
ACCESSION   XP_016877392
VERSION     XP_016877392.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021903.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 1% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..711
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..711
                     /product="protein-glutamine gamma-glutamyltransferase Z
                     isoform X1"
                     /calculated_mol_wt=79911
     Region          11..124
                     /region_name="Transglut_N"
                     /note="Transglutaminase family; pfam00868"
                     /db_xref="CDD:459971"
     Region          273..365
                     /region_name="TGc"
                     /note="Transglutaminase/protease-like homologues;
                     smart00460"
                     /db_xref="CDD:214673"
     Region          609..706
                     /region_name="Transglut_C"
                     /note="Transglutaminase family, C-terminal ig like domain;
                     pfam00927"
                     /db_xref="CDD:460002"
     CDS             1..711
                     /gene="TGM7"
                     /gene_synonym="TGMZ"
                     /coded_by="XM_017021903.1:1..2136"
                     /db_xref="GeneID:116179"
                     /db_xref="HGNC:HGNC:30790"
                     /db_xref="MIM:606776"
ORIGIN      
        1 miptmatlrl esvdlqssrn nkehhtqemg vkrltvrrgq pfylrlsfsr pfqsqndhit
       61 fvaetgpkps ellgtratff ltrvqpgnvw sasdftidsn slqvslftpa navighytlk
      121 ieisqgqghs vtyplgtfil lfnpwspedd vylpseillq eyimrdygfv ykgherfits
      181 wpwnygqfee diidicfeil nkslyhlknp akdcsqrndv vyvcrvvsam insnddngvl
      241 qgnwgedysk gvsplewkgs vailqqwsar ggqpvkygqc wvfasvmctv mrclgvptrv
      301 vsnfrsahnv drnltidtyy drnaemlstq krdkiwnfhv wnecwmirkd lppgyngwqv
      361 ldptpqqtss glfccgpasv kairegdvhl aydtpfvyae vnadeviwll gdgqaqeila
      421 hntssigkei stkmvgsdqr qsitssykyp egspeeravf mkasrkmlgp qraslpfldl
      481 lesgglrdqp aqlqlhlari pewgqdlqll lriqrvpdst hprgpiglvv rfcaqallhg
      541 ggtqkpfwrh tvrmnldfgk etqwplllpy snyrnkltde klirvsgiae veetgrsmlv
      601 lkdiclepph lsievserae vgkalrvhvt ltntlmvals sctmvlegsg lingqiakdl
      661 gtlvaghtlq iqldlyptka gprqlqvlis snevkeikgy kdifvtvaga p
//
LOCUS       XP_005254214             212 aa            linear   PRI 05-AUG-2025
DEFINITION  sentrin-specific protease 8 isoform X1 [Homo sapiens].
ACCESSION   XP_005254214
VERSION     XP_005254214.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254157.4
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 12% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..212
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..212
                     /product="sentrin-specific protease 8 isoform X1"
                     /calculated_mol_wt=23976
     Region          26..174
                     /region_name="Peptidase_C48"
                     /note="Ulp1 protease family, C-terminal catalytic domain;
                     cl23802"
                     /db_xref="CDD:420019"
     CDS             1..212
                     /gene="SENP8"
                     /gene_synonym="DEN1; NEDP1; PRSC2"
                     /coded_by="XM_005254157.4:206..844"
                     /db_xref="GeneID:123228"
                     /db_xref="HGNC:HGNC:22992"
                     /db_xref="MIM:608659"
ORIGIN      
        1 mdpvvlsymd sllrqsdvsl ldppswlndh iigfafeyfa nsqfhdcsdh vsfispevtq
       61 fikctsnpae iamflepldl pnkrvvflai ndnsnqaagg thwsllvylq dknsffhyds
      121 hsrsnsvhak qvaekleafl grkgdklafv eekapaqqns ydcgmyvicn tealcqnffr
      181 qqtesllqll tpayitkkrg ewkdlittla kk
//
LOCUS       XP_011519519             212 aa            linear   PRI 05-AUG-2025
DEFINITION  sentrin-specific protease 8 isoform X1 [Homo sapiens].
ACCESSION   XP_011519519
VERSION     XP_011519519.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521217.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..212
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..212
                     /product="sentrin-specific protease 8 isoform X1"
                     /calculated_mol_wt=23976
     Region          26..174
                     /region_name="Peptidase_C48"
                     /note="Ulp1 protease family, C-terminal catalytic domain;
                     cl23802"
                     /db_xref="CDD:420019"
     CDS             1..212
                     /gene="SENP8"
                     /gene_synonym="DEN1; NEDP1; PRSC2"
                     /coded_by="XM_011521217.3:68..706"
                     /db_xref="GeneID:123228"
                     /db_xref="HGNC:HGNC:22992"
                     /db_xref="MIM:608659"
ORIGIN      
        1 mdpvvlsymd sllrqsdvsl ldppswlndh iigfafeyfa nsqfhdcsdh vsfispevtq
       61 fikctsnpae iamflepldl pnkrvvflai ndnsnqaagg thwsllvylq dknsffhyds
      121 hsrsnsvhak qvaekleafl grkgdklafv eekapaqqns ydcgmyvicn tealcqnffr
      181 qqtesllqll tpayitkkrg ewkdlittla kk
//
LOCUS       XP_005254215             440 aa            linear   PRI 05-AUG-2025
DEFINITION  methionyl-tRNA formyltransferase, mitochondrial isoform X1 [Homo
            sapiens].
ACCESSION   XP_005254215
VERSION     XP_005254215.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254158.6
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Jun 6, 2016 this sequence version replaced XP_005254215.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..440
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..440
                     /product="methionyl-tRNA formyltransferase, mitochondrial
                     isoform X1"
                     /calculated_mol_wt=49266
     Region          49..411
                     /region_name="fmt"
                     /note="methionyl-tRNA formyltransferase; TIGR00460"
                     /db_xref="CDD:273088"
     CDS             1..440
                     /gene="MTFMT"
                     /gene_synonym="COXPD15; FMT1; MC1DN27"
                     /coded_by="XM_005254158.6:27..1349"
                     /db_xref="GeneID:123263"
                     /db_xref="HGNC:HGNC:29666"
                     /db_xref="MIM:611766"
ORIGIN      
        1 mrvlvrrcwg pplahgarrg rpspqwrala rlgwedcrds rvrekppwrv lffgtdqfar
       61 ealralhaar ypgqgsgdpa aeglqaapgr paprvldfwl rkawaaercg prsrrllapr
      121 renkeeelid klevvtmpsp spkglpvkqy avqsqlpvye wpdvgsgeyd vgvvasfgrl
      181 lnealilkfp ygilnvhpsc lprwrgpapv ihtvlhgdtv tgvtimqirp krfdvgpilk
      241 qetvpvppks takeleavls rlganmlisv lknlpeslsn grqqpmegat yapkisagts
      301 cikweeqtse qifrlyraig niiplqtlwm antiklldlv evnssvladp kltgqalipg
      361 sviyhkqsqi llvyckdgwi gvrsvmlkks ltatdfyngy lhpwyqknsq aqpsqcrfqt
      421 lrlptkkkqk ktvamqqcie
//
LOCUS       XP_005254216             128 aa            linear   PRI 05-AUG-2025
DEFINITION  organic solute transporter subunit beta isoform X1 [Homo sapiens].
ACCESSION   XP_005254216
VERSION     XP_005254216.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254159.6
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..128
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..128
                     /product="organic solute transporter subunit beta isoform
                     X1"
                     /calculated_mol_wt=14215
     Region          3..122
                     /region_name="OSTbeta"
                     /note="Organic solute transporter subunit beta protein;
                     pfam15048"
                     /db_xref="CDD:405697"
     CDS             1..128
                     /gene="SLC51B"
                     /gene_synonym="OSTB; OSTBETA; PBAM2; SLC51A1BP"
                     /coded_by="XM_005254159.6:304..690"
                     /db_xref="GeneID:123264"
                     /db_xref="HGNC:HGNC:29956"
                     /db_xref="MIM:612085"
ORIGIN      
        1 mehsegapgd pagtvvpqel leemlwffrv edaspwnhsi lalaavvvii smvllgrsiq
       61 asrkekmqpp eketpevlhl deakdhnsln nlretllsek pnlaqvelel kerdvlsvfl
      121 pdvpetes
//
LOCUS       XP_047288096             712 aa            linear   PRI 05-AUG-2025
DEFINITION  threonine--tRNA ligase 2, cytoplasmic isoform X1 [Homo sapiens].
ACCESSION   XP_047288096
VERSION     XP_047288096.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432140.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..712
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..712
                     /product="threonine--tRNA ligase 2, cytoplasmic isoform
                     X1"
                     /calculated_mol_wt=82434
     Region          122..691
                     /region_name="PLN02908"
                     /note="threonyl-tRNA synthetase"
                     /db_xref="CDD:178496"
     CDS             1..712
                     /gene="TARS3"
                     /gene_synonym="TARSL2; ThrRS-L"
                     /coded_by="XM_047432140.1:87..2225"
                     /db_xref="GeneID:123283"
                     /db_xref="HGNC:HGNC:24728"
ORIGIN      
        1 maaealaaea vasrlerqee dirwlwseve rlrdeqlnap yscqaegpcl trevaqlrae
       61 ncdlrhrlcs lrlclaeers rqatlesael eaaqeagaqp ppsqsqdkdm kkkkmkesea
      121 dsevkhqpif ikerlklfei lkkdhqllla iygkkgdtsn iitvrvadgq tvqgevwktt
      181 pyqvaaeisq elaestviak vngelwdldr plegdsslel ltfdneeaqa vywhssahil
      241 geamelyygg hlcygppien gfyydmfied ravsstelsa lenickaiik ekqpferlev
      301 skeillemfk ynkfkcriln ekvntatttv yrcgplidlc kgphvrhtgk iktikifkns
      361 stywegnpem etlqriygis fpdnkmmrdw ekfqeeaknr dhrkigkeqe lfffhdlspg
      421 scfflprgaf iyntltdfir eeyhkrdfte vlspnmynsk lweasghwqh ysenmftfei
      481 ekdtfalkpm ncpghclmfa hrprswremp irfadfgvlh rnelsgtlsg ltrvrrfqqd
      541 dahifctveq ieeeikgclq flqsvystfg fsfqlnlstr penflgeiem wneaekqlqn
      601 slmdfgepwk mnpgdgafyg pkidikikda igryhqcati qldfqlpirf nltyvskdgd
      661 dkkrpviihr ailgsvermi ailsenyggk wypvnflkkd lwltltwitv vh
//
LOCUS       XP_016877401             675 aa            linear   PRI 05-AUG-2025
DEFINITION  threonine--tRNA ligase 2, cytoplasmic isoform X2 [Homo sapiens].
ACCESSION   XP_016877401
VERSION     XP_016877401.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021912.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..675
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..675
                     /product="threonine--tRNA ligase 2, cytoplasmic isoform
                     X2"
                     /calculated_mol_wt=78062
     Region          122..>655
                     /region_name="PLN02908"
                     /note="threonyl-tRNA synthetase"
                     /db_xref="CDD:178496"
     CDS             1..675
                     /gene="TARS3"
                     /gene_synonym="TARSL2; ThrRS-L"
                     /coded_by="XM_017021912.3:87..2114"
                     /db_xref="GeneID:123283"
                     /db_xref="HGNC:HGNC:24728"
ORIGIN      
        1 maaealaaea vasrlerqee dirwlwseve rlrdeqlnap yscqaegpcl trevaqlrae
       61 ncdlrhrlcs lrlclaeers rqatlesael eaaqeagaqp ppsqsqdkdm kkkkmkesea
      121 dsevkhqpif ikerlklfei lkkdhqllla iygkkgdtsn iitvrvadgq tvqgevwktt
      181 pyqvaaeisq elaestviak vngelwdldr plegdsslel ltfdneeaqa vywhssahil
      241 geamelyygg hlcygppien gfyydmfied ravsstelsa lenickaiik ekqpferlev
      301 skeillemfk ynkfkcriln ekvntatttv yrcgplidlc kgphvrhtgk iktikifkns
      361 stywegnpem etlqriygis fpdnkmmrdw ekfqeeaknr dhrkigkeqe lfffhdlspg
      421 scfflprgaf iyntltdfir eeyhkrdfte vlspnmynsk lweasghwqh ysenmftfei
      481 ekdtfalkpm ncpghclmfa hrprswremp irfadfgvlh rnelsgtlsg ltrvrrfqqd
      541 dahifctveq ieeeikgclq flqsvystfg fsfqlnlstr penflgeiem wneaekqlqn
      601 slmdfgepwk mnpgdgafyg pkidikikda igryhqcati qldfqlpirf nltyvrmsck
      661 rshavssllr lasft
//
LOCUS       XP_047288098             559 aa            linear   PRI 05-AUG-2025
DEFINITION  threonine--tRNA ligase 2, cytoplasmic isoform X3 [Homo sapiens].
ACCESSION   XP_047288098
VERSION     XP_047288098.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432142.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..559
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..559
                     /product="threonine--tRNA ligase 2, cytoplasmic isoform
                     X3"
                     /calculated_mol_wt=65149
     Region          1..552
                     /region_name="PLN02908"
                     /note="threonyl-tRNA synthetase"
                     /db_xref="CDD:178496"
     CDS             1..559
                     /gene="TARS3"
                     /gene_synonym="TARSL2; ThrRS-L"
                     /coded_by="XM_047432142.1:112..1791"
                     /db_xref="GeneID:123283"
                     /db_xref="HGNC:HGNC:24728"
ORIGIN      
        1 melyygghlc ygppiengfy ydmfiedrav sstelsalen ickaiikekq pferlevske
       61 illemfkynk fkcrilnekv ntatttvyrc gplidlckgp hvrhtgkikt ikifknssty
      121 wegnpemetl qriygisfpd nkmmrdwekf qeeaknrdhr kigkeqelff fhdlspgscf
      181 flprgafiyn tltdfireey hkrdftevls pnmynsklwe asghwqhyse nmftfeiekd
      241 tfalkpmncp ghclmfahrp rswrempirf adfgvlhrne lsgtlsgltr vrrfqqddah
      301 ifctveqiee eikgclqflq svystfgfsf qlnlstrpen flgeiemwne aekqlqnslm
      361 dfgepwkmnp gdgafygpki dikikdaigr yhqcatiqld fqlpirfnlt yvskdgddkk
      421 rpviihrail gsvermiail senyggkwpf wlsprqvmvi pvgptcekya lqvsseffee
      481 gfmadvdldh sctlnkkirn aqlaqynfil vvgekekidn avnvrtrdnk ihgeilvtsa
      541 idklknlrkt rtlnaeeaf
//
LOCUS       XP_024305605             106 aa            linear   PRI 05-AUG-2025
DEFINITION  HIG1 domain family member 2B isoform X1 [Homo sapiens].
ACCESSION   XP_024305605
VERSION     XP_024305605.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449837.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..106
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..106
                     /product="HIG1 domain family member 2B isoform X1"
                     /calculated_mol_wt=11274
     Region          45..96
                     /region_name="HIG_1_N"
                     /note="Hypoxia induced protein conserved region;
                     pfam04588"
                     /db_xref="CDD:461361"
     CDS             1..106
                     /gene="HIGD2B"
                     /gene_synonym="HIGD2BP"
                     /coded_by="XM_024449837.2:600..920"
                     /db_xref="GeneID:123346"
                     /db_xref="HGNC:HGNC:26984"
ORIGIN      
        1 matlgfvtpe apfesskppi feglsptvys npegfkekfl rktrenpvvp igflctaavl
       61 tnglycfhqg nsqcsrlmmh tqiaaqgfti aaillglaat amkspp
//
LOCUS       XP_024305606             106 aa            linear   PRI 05-AUG-2025
DEFINITION  HIG1 domain family member 2B isoform X1 [Homo sapiens].
ACCESSION   XP_024305606
VERSION     XP_024305606.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449838.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..106
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..106
                     /product="HIG1 domain family member 2B isoform X1"
                     /calculated_mol_wt=11274
     Region          45..96
                     /region_name="HIG_1_N"
                     /note="Hypoxia induced protein conserved region;
                     pfam04588"
                     /db_xref="CDD:461361"
     CDS             1..106
                     /gene="HIGD2B"
                     /gene_synonym="HIGD2BP"
                     /coded_by="XM_024449838.2:700..1020"
                     /db_xref="GeneID:123346"
                     /db_xref="HGNC:HGNC:26984"
ORIGIN      
        1 matlgfvtpe apfesskppi feglsptvys npegfkekfl rktrenpvvp igflctaavl
       61 tnglycfhqg nsqcsrlmmh tqiaaqgfti aaillglaat amkspp
//
LOCUS       XP_024305607             106 aa            linear   PRI 05-AUG-2025
DEFINITION  HIG1 domain family member 2B isoform X1 [Homo sapiens].
ACCESSION   XP_024305607
VERSION     XP_024305607.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449839.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..106
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..106
                     /product="HIG1 domain family member 2B isoform X1"
                     /calculated_mol_wt=11274
     Region          45..96
                     /region_name="HIG_1_N"
                     /note="Hypoxia induced protein conserved region;
                     pfam04588"
                     /db_xref="CDD:461361"
     CDS             1..106
                     /gene="HIGD2B"
                     /gene_synonym="HIGD2BP"
                     /coded_by="XM_024449839.2:658..978"
                     /db_xref="GeneID:123346"
                     /db_xref="HGNC:HGNC:26984"
ORIGIN      
        1 matlgfvtpe apfesskppi feglsptvys npegfkekfl rktrenpvvp igflctaavl
       61 tnglycfhqg nsqcsrlmmh tqiaaqgfti aaillglaat amkspp
//
LOCUS       XP_024305608             106 aa            linear   PRI 05-AUG-2025
DEFINITION  HIG1 domain family member 2B isoform X1 [Homo sapiens].
ACCESSION   XP_024305608
VERSION     XP_024305608.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449840.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..106
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..106
                     /product="HIG1 domain family member 2B isoform X1"
                     /calculated_mol_wt=11274
     Region          45..96
                     /region_name="HIG_1_N"
                     /note="Hypoxia induced protein conserved region;
                     pfam04588"
                     /db_xref="CDD:461361"
     CDS             1..106
                     /gene="HIGD2B"
                     /gene_synonym="HIGD2BP"
                     /coded_by="XM_024449840.2:507..827"
                     /db_xref="GeneID:123346"
                     /db_xref="HGNC:HGNC:26984"
ORIGIN      
        1 matlgfvtpe apfesskppi feglsptvys npegfkekfl rktrenpvvp igflctaavl
       61 tnglycfhqg nsqcsrlmmh tqiaaqgfti aaillglaat amkspp
//
LOCUS       XP_024305609             106 aa            linear   PRI 05-AUG-2025
DEFINITION  HIG1 domain family member 2B isoform X1 [Homo sapiens].
ACCESSION   XP_024305609
VERSION     XP_024305609.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449841.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..106
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..106
                     /product="HIG1 domain family member 2B isoform X1"
                     /calculated_mol_wt=11274
     Region          45..96
                     /region_name="HIG_1_N"
                     /note="Hypoxia induced protein conserved region;
                     pfam04588"
                     /db_xref="CDD:461361"
     CDS             1..106
                     /gene="HIGD2B"
                     /gene_synonym="HIGD2BP"
                     /coded_by="XM_024449841.2:355..675"
                     /db_xref="GeneID:123346"
                     /db_xref="HGNC:HGNC:26984"
ORIGIN      
        1 matlgfvtpe apfesskppi feglsptvys npegfkekfl rktrenpvvp igflctaavl
       61 tnglycfhqg nsqcsrlmmh tqiaaqgfti aaillglaat amkspp
//
LOCUS       XP_024305610             106 aa            linear   PRI 05-AUG-2025
DEFINITION  HIG1 domain family member 2B isoform X1 [Homo sapiens].
ACCESSION   XP_024305610
VERSION     XP_024305610.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449842.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..106
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..106
                     /product="HIG1 domain family member 2B isoform X1"
                     /calculated_mol_wt=11274
     Region          45..96
                     /region_name="HIG_1_N"
                     /note="Hypoxia induced protein conserved region;
                     pfam04588"
                     /db_xref="CDD:461361"
     CDS             1..106
                     /gene="HIGD2B"
                     /gene_synonym="HIGD2BP"
                     /coded_by="XM_024449842.2:255..575"
                     /db_xref="GeneID:123346"
                     /db_xref="HGNC:HGNC:26984"
ORIGIN      
        1 matlgfvtpe apfesskppi feglsptvys npegfkekfl rktrenpvvp igflctaavl
       61 tnglycfhqg nsqcsrlmmh tqiaaqgfti aaillglaat amkspp
//
LOCUS       XP_011519520             367 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 28 isoform X1 [Homo
            sapiens].
ACCESSION   XP_011519520
VERSION     XP_011519520.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521218.3
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 1% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..367
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..367
                     /product="leucine-rich repeat-containing protein 28
                     isoform X1"
                     /calculated_mol_wt=41781
     Region          <38..>221
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          43..66
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          67..89
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          90..135
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          136..158
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          159..181
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          182..204
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     CDS             1..367
                     /gene="LRRC28"
                     /coded_by="XM_011521218.3:337..1440"
                     /db_xref="GeneID:123355"
                     /db_xref="HGNC:HGNC:28355"
ORIGIN      
        1 maselcktis varlekhknl flnyrnlhhf plellkdegl qylerlymkr nsltslpenl
       61 aqklpnlvel ylhsnnivvv peaigslvkl qcldlsdnal eivcpeigrl ralrhlrlan
      121 nqlqflppev gdlkelqtld istnrlltlp erlhmclslq yltvdrnrlw yvprhlcqlp
      181 slnelsmagn rlaflpldlg rsrelqyvyv dnnihlkglp sylynkvigc sgcgapiqvs
      241 evkllsfssg qrtvflpaev kaigtehdhv lplqelamrg lyhtyhsllk dlnflspisl
      301 prsllellhc plghchrcse pmftivypkl fplretpmag lhqwkttvsf vayccstqcl
      361 qtfdlls
//
LOCUS       XP_011519522             343 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 28 isoform X2 [Homo
            sapiens].
ACCESSION   XP_011519522
VERSION     XP_011519522.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521220.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..343
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..343
                     /product="leucine-rich repeat-containing protein 28
                     isoform X2"
                     /calculated_mol_wt=39054
     Region          <38..>221
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          43..66
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          67..89
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          90..135
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          136..158
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          159..181
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          182..204
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     CDS             1..343
                     /gene="LRRC28"
                     /coded_by="XM_011521220.3:122..1153"
                     /db_xref="GeneID:123355"
                     /db_xref="HGNC:HGNC:28355"
ORIGIN      
        1 maselcktis varlekhknl flnyrnlhhf plellkdegl qylerlymkr nsltslpenl
       61 aqklpnlvel ylhsnnivvv peaigslvkl qcldlsdnal eivcpeigrl ralrhlrlan
      121 nqlqflppev gdlkelqtld istnrlltlp erlhmclslq yltvdrnrlw yvprhlcqlp
      181 slnelsmagn rlaflpldlg rsrelqyvyv dnnihlkglp sylynkvigc sgcgapiqvs
      241 evkllsfssg qrtvflpaev kaigtehdhv lplqelamrg lyhtyhsllk dlnflspisl
      301 prsllellhc plghchrcse pmftivypkl fplretpmag lhq
//
LOCUS       XP_047288101             343 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 28 isoform X2 [Homo
            sapiens].
ACCESSION   XP_047288101
VERSION     XP_047288101.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432145.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..343
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..343
                     /product="leucine-rich repeat-containing protein 28
                     isoform X2"
                     /calculated_mol_wt=39054
     Region          <38..>221
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          43..66
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          67..89
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          90..135
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          136..158
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          159..181
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          182..204
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     CDS             1..343
                     /gene="LRRC28"
                     /coded_by="XM_047432145.1:337..1368"
                     /db_xref="GeneID:123355"
                     /db_xref="HGNC:HGNC:28355"
ORIGIN      
        1 maselcktis varlekhknl flnyrnlhhf plellkdegl qylerlymkr nsltslpenl
       61 aqklpnlvel ylhsnnivvv peaigslvkl qcldlsdnal eivcpeigrl ralrhlrlan
      121 nqlqflppev gdlkelqtld istnrlltlp erlhmclslq yltvdrnrlw yvprhlcqlp
      181 slnelsmagn rlaflpldlg rsrelqyvyv dnnihlkglp sylynkvigc sgcgapiqvs
      241 evkllsfssg qrtvflpaev kaigtehdhv lplqelamrg lyhtyhsllk dlnflspisl
      301 prsllellhc plghchrcse pmftivypkl fplretpmag lhq
//
LOCUS       XP_011519523             276 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 28 isoform X3 [Homo
            sapiens].
ACCESSION   XP_011519523
VERSION     XP_011519523.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521221.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..276
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..276
                     /product="leucine-rich repeat-containing protein 28
                     isoform X3"
                     /calculated_mol_wt=31807
     Region          <38..>221
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          43..66
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          67..89
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          90..135
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          136..158
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          159..181
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          182..204
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     CDS             1..276
                     /gene="LRRC28"
                     /coded_by="XM_011521221.4:122..952"
                     /db_xref="GeneID:123355"
                     /db_xref="HGNC:HGNC:28355"
ORIGIN      
        1 maselcktis varlekhknl flnyrnlhhf plellkdegl qylerlymkr nsltslpenl
       61 aqklpnlvel ylhsnnivvv peaigslvkl qcldlsdnal eivcpeigrl ralrhlrlan
      121 nqlqflppev gdlkelqtld istnrlltlp erlhmclslq yltvdrnrlw yvprhlcqlp
      181 slnelsmagn rlaflpldlg rsrelqyvyv dnnihlkglp sylynkvigc sgwrikclqs
      241 pwyiercqqa pklkalfptp kpsettlkcd lhlchn
//
LOCUS       XP_047288102             272 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 28 isoform X4 [Homo
            sapiens].
ACCESSION   XP_047288102
VERSION     XP_047288102.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432146.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..272
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..272
                     /product="leucine-rich repeat-containing protein 28
                     isoform X4"
                     /calculated_mol_wt=31603
     Region          <5..>209
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          43..66
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          67..89
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          90..112
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          113..148
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          149..177
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          178..200
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     CDS             1..272
                     /gene="LRRC28"
                     /coded_by="XM_047432146.1:122..940"
                     /db_xref="GeneID:123355"
                     /db_xref="HGNC:HGNC:28355"
ORIGIN      
        1 maselcktis varlekhknl flnyrnlhhf plellkdegl qylerlymkr nsltslpenl
       61 aqklpnlvel ylhsnnivvv peaigslvkl qcldlsdnal eivcpeigrl ralrhlrlan
      121 nqlqflppdh enialnwcsc ehswtnrylr cvlfhkyltv drnrlwyvpr hlcqlpslne
      181 lsmagnrlaf lpldlgrsre lqyvyvdnni hlkglpsyly nkvigcsgwr ikclqspwyi
      241 ercqqapklk alfptpkpse ttlkcdlhlc hn
//
LOCUS       XP_006720452             247 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 28 isoform X5 [Homo
            sapiens].
ACCESSION   XP_006720452
VERSION     XP_006720452.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720389.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..247
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..247
                     /product="leucine-rich repeat-containing protein 28
                     isoform X5"
                     /calculated_mol_wt=28243
     Region          <38..>221
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          43..66
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          67..89
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          90..135
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          136..158
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          159..181
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          182..204
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     CDS             1..247
                     /gene="LRRC28"
                     /coded_by="XM_006720389.5:122..865"
                     /db_xref="GeneID:123355"
                     /db_xref="HGNC:HGNC:28355"
ORIGIN      
        1 maselcktis varlekhknl flnyrnlhhf plellkdegl qylerlymkr nsltslpenl
       61 aqklpnlvel ylhsnnivvv peaigslvkl qcldlsdnal eivcpeigrl ralrhlrlan
      121 nqlqflppev gdlkelqtld istnrlltlp erlhmclslq yltvdrnrlw yvprhlcqlp
      181 slnelsmagn rlaflpldlg rsrelqyvyv dnnihlkglp sylynkvigc sgstlftvgg
      241 dymesdh
//
LOCUS       XP_016877403             247 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 28 isoform X5 [Homo
            sapiens].
ACCESSION   XP_016877403
VERSION     XP_016877403.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021914.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..247
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..247
                     /product="leucine-rich repeat-containing protein 28
                     isoform X5"
                     /calculated_mol_wt=28243
     Region          <38..>221
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          43..66
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          67..89
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          90..135
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          136..158
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          159..181
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          182..204
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     CDS             1..247
                     /gene="LRRC28"
                     /coded_by="XM_017021914.2:565..1308"
                     /db_xref="GeneID:123355"
                     /db_xref="HGNC:HGNC:28355"
ORIGIN      
        1 maselcktis varlekhknl flnyrnlhhf plellkdegl qylerlymkr nsltslpenl
       61 aqklpnlvel ylhsnnivvv peaigslvkl qcldlsdnal eivcpeigrl ralrhlrlan
      121 nqlqflppev gdlkelqtld istnrlltlp erlhmclslq yltvdrnrlw yvprhlcqlp
      181 slnelsmagn rlaflpldlg rsrelqyvyv dnnihlkglp sylynkvigc sgstlftvgg
      241 dymesdh
//
LOCUS       XP_047288104             247 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 28 isoform X6 [Homo
            sapiens].
ACCESSION   XP_047288104
VERSION     XP_047288104.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432148.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..247
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..247
                     /product="leucine-rich repeat-containing protein 28
                     isoform X6"
                     /calculated_mol_wt=28241
     Region          <38..>221
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          43..66
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          67..89
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          90..135
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          136..158
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          159..181
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          182..204
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     CDS             1..247
                     /gene="LRRC28"
                     /coded_by="XM_047432148.1:122..865"
                     /db_xref="GeneID:123355"
                     /db_xref="HGNC:HGNC:28355"
ORIGIN      
        1 maselcktis varlekhknl flnyrnlhhf plellkdegl qylerlymkr nsltslpenl
       61 aqklpnlvel ylhsnnivvv peaigslvkl qcldlsdnal eivcpeigrl ralrhlrlan
      121 nqlqflppev gdlkelqtld istnrlltlp erlhmclslq yltvdrnrlw yvprhlcqlp
      181 slnelsmagn rlaflpldlg rsrelqyvyv dnnihlkglp sylynkvigc sgllycctcc
      241 slclecs
//
LOCUS       XP_047288105             213 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 28 isoform X7 [Homo
            sapiens].
ACCESSION   XP_047288105
VERSION     XP_047288105.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432149.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 1% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..213
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..213
                     /product="leucine-rich repeat-containing protein 28
                     isoform X7"
                     /calculated_mol_wt=24062
     Region          <4..>71
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          5..27
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          28..50
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     CDS             1..213
                     /gene="LRRC28"
                     /coded_by="XM_047432149.1:122..763"
                     /db_xref="GeneID:123355"
                     /db_xref="HGNC:HGNC:28355"
ORIGIN      
        1 mclslqyltv drnrlwyvpr hlcqlpslne lsmagnrlaf lpldlgrsre lqyvyvdnni
       61 hlkglpsyly nkvigcsgcg apiqvsevkl lsfssgqrtv flpaevkaig tehdhvlplq
      121 elamrglyht yhsllkdlnf lspislprsl lellhcplgh chrcsepmft ivypklfplr
      181 etpmaglhqw kttvsfvayc cstqclqtfd lls
//
LOCUS       XP_047288106             213 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 28 isoform X7 [Homo
            sapiens].
ACCESSION   XP_047288106
VERSION     XP_047288106.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432150.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 1% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..213
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..213
                     /product="leucine-rich repeat-containing protein 28
                     isoform X7"
                     /calculated_mol_wt=24062
     Region          <4..>71
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          5..27
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          28..50
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     CDS             1..213
                     /gene="LRRC28"
                     /coded_by="XM_047432150.1:312..953"
                     /db_xref="GeneID:123355"
                     /db_xref="HGNC:HGNC:28355"
ORIGIN      
        1 mclslqyltv drnrlwyvpr hlcqlpslne lsmagnrlaf lpldlgrsre lqyvyvdnni
       61 hlkglpsyly nkvigcsgcg apiqvsevkl lsfssgqrtv flpaevkaig tehdhvlplq
      121 elamrglyht yhsllkdlnf lspislprsl lellhcplgh chrcsepmft ivypklfplr
      181 etpmaglhqw kttvsfvayc cstqclqtfd lls
//
LOCUS       XP_016877404             531 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 266 isoform X1 [Homo sapiens].
ACCESSION   XP_016877404
VERSION     XP_016877404.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021915.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..531
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..531
                     /product="transmembrane protein 266 isoform X1"
                     /calculated_mol_wt=58313
     Region          100..>218
                     /region_name="Ion_trans"
                     /note="Ion transport protein; pfam00520"
                     /db_xref="CDD:459842"
     CDS             1..531
                     /gene="TMEM266"
                     /gene_synonym="C15orf27; HsHVRP1; hTMEM266; HVRP1"
                     /coded_by="XM_017021915.2:371..1966"
                     /db_xref="GeneID:123591"
                     /db_xref="HGNC:HGNC:26763"
                     /db_xref="MIM:618691"
ORIGIN      
        1 mavapsfnmt npqpaieggi seveiisqqv deetksiapv qlvnfayrdl plaavdlsta
       61 gsqllsnlde dyqregsnwl kpccgkraav wqvfllsasl nsflvacvil vvilltlell
      121 idikllqfss afqfagvihw islvilsvff setvlrivvl giwdyienki evfdgaviil
      181 slapmvastv angprspwda isliimlriw rvkrvidayv lpvklememv iqqyekakvi
      241 qdeqlerltq icqeqgfeir qlrahlaqqd ldlaaereaa lqaphvlsqp rsrfkvleag
      301 twdeetaaes vveelqpsqe atmkddmnsy isqyyngpss dsgvpepavc mvttaaidih
      361 qpnissdlfs ldmplklggn gtsatsesas rssvtraqsd ssqtlgssmd cstareepss
      421 epgpsppplp sqqqveeatv qdllsslsed pcpsqkaldp aplarpspag saqtspeleh
      481 rvslfnqknq egftvfqirp vihfqptvpm ledkfrsles keqklhrvpe a
//
LOCUS       XP_047288107             531 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 266 isoform X1 [Homo sapiens].
ACCESSION   XP_047288107
VERSION     XP_047288107.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432151.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..531
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..531
                     /product="transmembrane protein 266 isoform X1"
                     /calculated_mol_wt=58313
     Region          100..>218
                     /region_name="Ion_trans"
                     /note="Ion transport protein; pfam00520"
                     /db_xref="CDD:459842"
     CDS             1..531
                     /gene="TMEM266"
                     /gene_synonym="C15orf27; HsHVRP1; hTMEM266; HVRP1"
                     /coded_by="XM_047432151.1:431..2026"
                     /db_xref="GeneID:123591"
                     /db_xref="HGNC:HGNC:26763"
                     /db_xref="MIM:618691"
ORIGIN      
        1 mavapsfnmt npqpaieggi seveiisqqv deetksiapv qlvnfayrdl plaavdlsta
       61 gsqllsnlde dyqregsnwl kpccgkraav wqvfllsasl nsflvacvil vvilltlell
      121 idikllqfss afqfagvihw islvilsvff setvlrivvl giwdyienki evfdgaviil
      181 slapmvastv angprspwda isliimlriw rvkrvidayv lpvklememv iqqyekakvi
      241 qdeqlerltq icqeqgfeir qlrahlaqqd ldlaaereaa lqaphvlsqp rsrfkvleag
      301 twdeetaaes vveelqpsqe atmkddmnsy isqyyngpss dsgvpepavc mvttaaidih
      361 qpnissdlfs ldmplklggn gtsatsesas rssvtraqsd ssqtlgssmd cstareepss
      421 epgpsppplp sqqqveeatv qdllsslsed pcpsqkaldp aplarpspag saqtspeleh
      481 rvslfnqknq egftvfqirp vihfqptvpm ledkfrsles keqklhrvpe a
//
LOCUS       XP_005254217             347 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 266 isoform X2 [Homo sapiens].
ACCESSION   XP_005254217
VERSION     XP_005254217.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254160.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..347
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..347
                     /product="transmembrane protein 266 isoform X2"
                     /calculated_mol_wt=38118
     CDS             1..347
                     /gene="TMEM266"
                     /gene_synonym="C15orf27; HsHVRP1; hTMEM266; HVRP1"
                     /coded_by="XM_005254160.4:263..1306"
                     /db_xref="GeneID:123591"
                     /db_xref="HGNC:HGNC:26763"
                     /db_xref="MIM:618691"
ORIGIN      
        1 mvastvangp rspwdaisli imlriwrvkr vidayvlpvk lememviqqy ekakviqdeq
       61 lerltqicqe qgfeirqlra hlaqqdldla aereaalqap hvlsqprsrf kvleagtwde
      121 etaaesvvee lqpsqeatmk ddmnsyisqy yngpssdsgv pepavcmvtt aaidihqpni
      181 ssdlfsldmp lklggngtsa tsesasrssv traqsdssqt lgssmdcsta reepssepgp
      241 sppplpsqqq veeatvqdll sslsedpcps qkaldpapla rpspagsaqt spelehrvsl
      301 fnqknqegft vfqirpvihf qptvpmledk frsleskeqk lhrvpea
//
LOCUS       XP_016877407            1110 aa            linear   PRI 05-AUG-2025
DEFINITION  cytosolic carboxypeptidase 4 isoform X1 [Homo sapiens].
ACCESSION   XP_016877407
VERSION     XP_016877407.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021918.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1110
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1110
                     /product="cytosolic carboxypeptidase 4 isoform X1"
                     /calculated_mol_wt=124238
     Region          585..719
                     /region_name="Pepdidase_M14_N"
                     /note="Cytosolic carboxypeptidase N-terminal domain;
                     pfam18027"
                     /db_xref="CDD:407865"
     Region          743..1008
                     /region_name="M14_Nna1"
                     /note="Peptidase M14-like domain of ATP/GTP binding
                     proteins and cytosolic carboxypeptidases; cd06906"
                     /db_xref="CDD:349477"
     Site            order(793,796,843,852..853,890..891,900,975)
                     /site_type="active"
                     /db_xref="CDD:349477"
     CDS             1..1110
                     /gene="AGBL1"
                     /gene_synonym="CCP4; FECD8"
                     /coded_by="XM_017021918.3:354..3686"
                     /db_xref="GeneID:123624"
                     /db_xref="HGNC:HGNC:26504"
                     /db_xref="MIM:615496"
ORIGIN      
        1 maeqeasglq vllhtlqsss dkesiltilk vlgdllsvgt drrihymisk ggseallqtl
       61 vdtartappd ydillplfrl lakvglrdkk igrkalelea ldvtlilark nlshgqnllh
      121 clwalrvfas svsmgamlgi ngamellfkv itpytrkrtq airaatevla allksksngr
      181 ravnrgyvts llglhqdwhs hdtanayvqi rrglllclrh iaalrsgrea flaaqgmeil
      241 fsttqncldd ksmepvisvv lqilrqcypt splplvtass ayafpvpgci ttepphdlpe
      301 edfeddgdde vdkdsdtedg kvedddletd vnklsskpgl drpeeelmqy eelqsklgdd
      361 lnsektqyan hhhipaaass kqhcyskdqs scgqereyav qtsllcrvkt grstvhlgsk
      421 knpgvnlyqn vqsnslrrds seseipdiqa spkadawdvd aifcprmsas fsnstrtrev
      481 vkvidkllqt hlkrvpfhdp ylymakarrt ssvvdfkmma fpdvwghcpp pttqpmlerk
      541 cgvqrirife dirrliqpsd vinkvvfsld epwplqdnas nclrffskfe sgnlrkaiqv
      601 refeydllvn advnstqhqq wfyfkvsgmq aaipyhfnii ncekpnsqfn ygmqptlysv
      661 keallgkptw irtgheicyy knhyrqstav aggasgkcyy tltfavtfph sedvcylayh
      721 ypytytalmt hldileksvn lkevyfrqdv lcqtlggnpc plvtitampe snsdehleqf
      781 rhrpyqvita rvhpgesnas wvmkgtlefl vssdpvarll renfifkiip mlnpdgving
      841 nhrcslsged lnrqwlspsa hlqptiyhak gllyhlssig rspvvfcdfh ghsqkknvfl
      901 ygcsiketlw qaactvgtst ileevnyrtl pkildklapa ftmsscsflv eksrastarv
      961 vvwremgvsr sytmessycg cnqgpyqglq fgtreleemg amfclgllil elksascshq
     1021 llaqaatlls aeedaldqhl qrcssssgsv pseledepac leeidystdn ssdqegslse
     1081 ldrriqecaf nkfegeeeee apgqggeaip
//
LOCUS       XP_016877408            1093 aa            linear   PRI 05-AUG-2025
DEFINITION  cytosolic carboxypeptidase 4 isoform X2 [Homo sapiens].
ACCESSION   XP_016877408
VERSION     XP_016877408.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021919.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1093
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1093
                     /product="cytosolic carboxypeptidase 4 isoform X2"
                     /calculated_mol_wt=122159
     Region          568..702
                     /region_name="Pepdidase_M14_N"
                     /note="Cytosolic carboxypeptidase N-terminal domain;
                     pfam18027"
                     /db_xref="CDD:407865"
     Region          726..991
                     /region_name="M14_Nna1"
                     /note="Peptidase M14-like domain of ATP/GTP binding
                     proteins and cytosolic carboxypeptidases; cd06906"
                     /db_xref="CDD:349477"
     Site            order(776,779,826,835..836,873..874,883,958)
                     /site_type="active"
                     /db_xref="CDD:349477"
     CDS             1..1093
                     /gene="AGBL1"
                     /gene_synonym="CCP4; FECD8"
                     /coded_by="XM_017021919.3:354..3635"
                     /db_xref="GeneID:123624"
                     /db_xref="HGNC:HGNC:26504"
                     /db_xref="MIM:615496"
ORIGIN      
        1 maeqeasglq vllhtlqsss dkesiltilk vlgdllsvgt drrihymisk ggseallqtl
       61 vdtartappd ydillplfrl lakvglrdkk igrkalelea ldvtlilark nlshgqnllh
      121 clwalrvfas svsmgamlgi ngamellfkv itpytrkrtq airaatevla allksksngr
      181 ravnrgyvts llglhqdwhs hdtanayvqi rrglllclrh iaalrsgrea flaaqgmeil
      241 fsttqncldd ksmepvisvv lqilrqcypt splplvtass ayafpvpgci ttepphdlpe
      301 edfeddgdde vdkdsdtedg kvedddletd vnklsskpgl drpeeelmqy evmclelsys
      361 feelqsklgd dlnsektqya nhhhipaaas skqhcyskdq sscgqereya vqtsllcrvk
      421 tgrstvhlgs kknpgvnlyq nvqsnslrrd sseseipdiq aspkadawdv daifcprmsa
      481 sfsnstrtre vvkvidkllq thlkrvpfhd pylymakarr tssvvdfkmm afpdvwghcp
      541 ppttqpmler kcgvqrplqd nasnclrffs kfesgnlrka iqvrefeydl lvnadvnstq
      601 hqqwfyfkvs gmqaaipyhf niincekpns qfnygmqptl ysvkeallgk ptwirtghei
      661 cyyknhyrqs tavaggasgk cyytltfavt fphsedvcyl ayhypytyta lmthldilek
      721 svnlkevyfr qdvlcqtlgg npcplvtita mpesnsdehl eqfrhrpyqv itarvhpges
      781 naswvmkgtl eflvssdpva rllrenfifk iipmlnpdgv ingnhrcsls gedlnrqwls
      841 psahlqptiy hakgllyhls sigrspvvfc dfhghsqkkn vflygcsike tlwqaactvg
      901 tstileevny rtlpkildkl apaftmsscs flveksrast arvvvwremg vsrsytmess
      961 ycgcnqgpyq glqfgtrele emgamfclgl lilelksasc shqllaqaat llsaeedald
     1021 qhlqrcssss gsvpselede pacleeidys tdnssdqegs lseldrriqe cafnkfegee
     1081 eeeapgqgge aip
//
LOCUS       XP_011519529            1057 aa            linear   PRI 05-AUG-2025
DEFINITION  cytosolic carboxypeptidase 4 isoform X3 [Homo sapiens].
ACCESSION   XP_011519529
VERSION     XP_011519529.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521227.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1057
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1057
                     /product="cytosolic carboxypeptidase 4 isoform X3"
                     /calculated_mol_wt=118661
     Region          596..730
                     /region_name="Pepdidase_M14_N"
                     /note="Cytosolic carboxypeptidase N-terminal domain;
                     pfam18027"
                     /db_xref="CDD:407865"
     Region          754..1019
                     /region_name="M14_Nna1"
                     /note="Peptidase M14-like domain of ATP/GTP binding
                     proteins and cytosolic carboxypeptidases; cd06906"
                     /db_xref="CDD:349477"
     Site            order(804,807,854,863..864,901..902,911,986)
                     /site_type="active"
                     /db_xref="CDD:349477"
     CDS             1..1057
                     /gene="AGBL1"
                     /gene_synonym="CCP4; FECD8"
                     /coded_by="XM_011521227.4:354..3527"
                     /db_xref="GeneID:123624"
                     /db_xref="HGNC:HGNC:26504"
                     /db_xref="MIM:615496"
ORIGIN      
        1 maeqeasglq vllhtlqsss dkesiltilk vlgdllsvgt drrihymisk ggseallqtl
       61 vdtartappd ydillplfrl lakvglrdkk igrkalelea ldvtlilark nlshgqnllh
      121 clwalrvfas svsmgamlgi ngamellfkv itpytrkrtq airaatevla allksksngr
      181 ravnrgyvts llglhqdwhs hdtanayvqi rrglllclrh iaalrsgrea flaaqgmeil
      241 fsttqncldd ksmepvisvv lqilrqcypt splplvtass ayafpvpgci ttepphdlpe
      301 edfeddgdde vdkdsdtedg kvedddletd vnklsskpgl drpeeelmqy evmclelsys
      361 feelqsklgd dlnsektqya nhhhipaaas skqhcyskdq sscgqereya vqtsllcrvk
      421 tgrstvhlgs kknpgvnlyq nvqsnslrrd sseseipdiq aspkadawdv daifcprmsa
      481 sfsnstrtre vvkvidkllq thlkrvpfhd pylymakarr tssvvdfkmm afpdvwghcp
      541 ppttqpmler kcgvqririf edirrliqps dvinkvvfsl depwplqdna snclrffskf
      601 esgnlrkaiq vrefeydllv nadvnstqhq qwfyfkvsgm qaaipyhfni incekpnsqf
      661 nygmqptlys vkeallgkpt wirtgheicy yknhyrqsta vaggasgkcy ytltfavtfp
      721 hsedvcylay hypytytalm thldileksv nlkevyfrqd vlcqtlggnp cplvtitamp
      781 esnsdehleq frhrpyqvit arvhpgesna swvmkgtlef lvssdpvarl lrenfifkii
      841 pmlnpdgvin gnhrcslsge dlnrqwlsps ahlqptiyha kgllyhlssi grspvvfcdf
      901 hghsqkknvf lygcsiketl wqaactvgts tileevnyrt lpkildklap aftmsscsfl
      961 veksrastar vvvwremgvs rsytmessyc gcnqgpyqgl qfgtreleem gamfclglli
     1021 lelksascsh qllaqaatll saeedaldqh lqrvcdt
//
LOCUS       XP_016877409             862 aa            linear   PRI 05-AUG-2025
DEFINITION  cytosolic carboxypeptidase 4 isoform X4 [Homo sapiens].
ACCESSION   XP_016877409
VERSION     XP_016877409.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021920.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..862
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..862
                     /product="cytosolic carboxypeptidase 4 isoform X4"
                     /calculated_mol_wt=96976
     Region          596..730
                     /region_name="Pepdidase_M14_N"
                     /note="Cytosolic carboxypeptidase N-terminal domain;
                     pfam18027"
                     /db_xref="CDD:407865"
     Region          754..>851
                     /region_name="Peptidase_M14_like"
                     /note="M14 family of metallocarboxypeptidases and related
                     proteins; cl11393"
                     /db_xref="CDD:472171"
     CDS             1..862
                     /gene="AGBL1"
                     /gene_synonym="CCP4; FECD8"
                     /coded_by="XM_017021920.3:354..2942"
                     /db_xref="GeneID:123624"
                     /db_xref="HGNC:HGNC:26504"
                     /db_xref="MIM:615496"
ORIGIN      
        1 maeqeasglq vllhtlqsss dkesiltilk vlgdllsvgt drrihymisk ggseallqtl
       61 vdtartappd ydillplfrl lakvglrdkk igrkalelea ldvtlilark nlshgqnllh
      121 clwalrvfas svsmgamlgi ngamellfkv itpytrkrtq airaatevla allksksngr
      181 ravnrgyvts llglhqdwhs hdtanayvqi rrglllclrh iaalrsgrea flaaqgmeil
      241 fsttqncldd ksmepvisvv lqilrqcypt splplvtass ayafpvpgci ttepphdlpe
      301 edfeddgdde vdkdsdtedg kvedddletd vnklsskpgl drpeeelmqy evmclelsys
      361 feelqsklgd dlnsektqya nhhhipaaas skqhcyskdq sscgqereya vqtsllcrvk
      421 tgrstvhlgs kknpgvnlyq nvqsnslrrd sseseipdiq aspkadawdv daifcprmsa
      481 sfsnstrtre vvkvidkllq thlkrvpfhd pylymakarr tssvvdfkmm afpdvwghcp
      541 ppttqpmler kcgvqririf edirrliqps dvinkvvfsl depwplqdna snclrffskf
      601 esgnlrkaiq vrefeydllv nadvnstqhq qwfyfkvsgm qaaipyhfni incekpnsqf
      661 nygmqptlys vkeallgkpt wirtgheicy yknhyrqsta vaggasgkcy ytltfavtfp
      721 hsedvcylay hypytytalm thldileksv nlkevyfrqd vlcqtlggnp cplvtitamp
      781 esnsdehleq frhrpyqvit arvhpgesna swvmkgtlef lvssdpvarl lrenfifkii
      841 pmlnpdgvin gkpkneteak gd
//
LOCUS       XP_011519530             795 aa            linear   PRI 05-AUG-2025
DEFINITION  cytosolic carboxypeptidase 4 isoform X5 [Homo sapiens].
ACCESSION   XP_011519530
VERSION     XP_011519530.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521228.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..795
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..795
                     /product="cytosolic carboxypeptidase 4 isoform X5"
                     /calculated_mol_wt=89386
     Region          596..730
                     /region_name="Pepdidase_M14_N"
                     /note="Cytosolic carboxypeptidase N-terminal domain;
                     pfam18027"
                     /db_xref="CDD:407865"
     Region          754..>795
                     /region_name="Peptidase_M14_like"
                     /note="M14 family of metallocarboxypeptidases and related
                     proteins; cl11393"
                     /db_xref="CDD:472171"
     CDS             1..795
                     /gene="AGBL1"
                     /gene_synonym="CCP4; FECD8"
                     /coded_by="XM_011521228.4:354..2741"
                     /db_xref="GeneID:123624"
                     /db_xref="HGNC:HGNC:26504"
                     /db_xref="MIM:615496"
ORIGIN      
        1 maeqeasglq vllhtlqsss dkesiltilk vlgdllsvgt drrihymisk ggseallqtl
       61 vdtartappd ydillplfrl lakvglrdkk igrkalelea ldvtlilark nlshgqnllh
      121 clwalrvfas svsmgamlgi ngamellfkv itpytrkrtq airaatevla allksksngr
      181 ravnrgyvts llglhqdwhs hdtanayvqi rrglllclrh iaalrsgrea flaaqgmeil
      241 fsttqncldd ksmepvisvv lqilrqcypt splplvtass ayafpvpgci ttepphdlpe
      301 edfeddgdde vdkdsdtedg kvedddletd vnklsskpgl drpeeelmqy evmclelsys
      361 feelqsklgd dlnsektqya nhhhipaaas skqhcyskdq sscgqereya vqtsllcrvk
      421 tgrstvhlgs kknpgvnlyq nvqsnslrrd sseseipdiq aspkadawdv daifcprmsa
      481 sfsnstrtre vvkvidkllq thlkrvpfhd pylymakarr tssvvdfkmm afpdvwghcp
      541 ppttqpmler kcgvqririf edirrliqps dvinkvvfsl depwplqdna snclrffskf
      601 esgnlrkaiq vrefeydllv nadvnstqhq qwfyfkvsgm qaaipyhfni incekpnsqf
      661 nygmqptlys vkeallgkpt wirtgheicy yknhyrqsta vaggasgkcy ytltfavtfp
      721 hsedvcylay hypytytalm thldileksv nlkevyfrqd vlcqtlggnp cplvtitamp
      781 esnsdehleq fqpgp
//
LOCUS       XP_016877410             725 aa            linear   PRI 05-AUG-2025
DEFINITION  cytosolic carboxypeptidase 4 isoform X6 [Homo sapiens].
ACCESSION   XP_016877410
VERSION     XP_016877410.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021921.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..725
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..725
                     /product="cytosolic carboxypeptidase 4 isoform X6"
                     /calculated_mol_wt=81725
     Region          596..>652
                     /region_name="Pepdidase_M14_N"
                     /note="Cytosolic carboxypeptidase N-terminal domain;
                     pfam18027"
                     /db_xref="CDD:407865"
     CDS             1..725
                     /gene="AGBL1"
                     /gene_synonym="CCP4; FECD8"
                     /coded_by="XM_017021921.3:354..2531"
                     /db_xref="GeneID:123624"
                     /db_xref="HGNC:HGNC:26504"
                     /db_xref="MIM:615496"
ORIGIN      
        1 maeqeasglq vllhtlqsss dkesiltilk vlgdllsvgt drrihymisk ggseallqtl
       61 vdtartappd ydillplfrl lakvglrdkk igrkalelea ldvtlilark nlshgqnllh
      121 clwalrvfas svsmgamlgi ngamellfkv itpytrkrtq airaatevla allksksngr
      181 ravnrgyvts llglhqdwhs hdtanayvqi rrglllclrh iaalrsgrea flaaqgmeil
      241 fsttqncldd ksmepvisvv lqilrqcypt splplvtass ayafpvpgci ttepphdlpe
      301 edfeddgdde vdkdsdtedg kvedddletd vnklsskpgl drpeeelmqy evmclelsys
      361 feelqsklgd dlnsektqya nhhhipaaas skqhcyskdq sscgqereya vqtsllcrvk
      421 tgrstvhlgs kknpgvnlyq nvqsnslrrd sseseipdiq aspkadawdv daifcprmsa
      481 sfsnstrtre vvkvidkllq thlkrvpfhd pylymakarr tssvvdfkmm afpdvwghcp
      541 ppttqpmler kcgvqririf edirrliqps dvinkvvfsl depwplqdna snclrffskf
      601 esgnlrkaiq vrefeydllv nadvnstqhq qwfyfkvsgm qaaipyhfni incekpnsqf
      661 nygmqptlys vkeallgkpt wirtgheicy ykliltswkr vstskrstsg kmfsarrweg
      721 irvpw
//
LOCUS       XP_011519532             613 aa            linear   PRI 05-AUG-2025
DEFINITION  cytosolic carboxypeptidase 4 isoform X7 [Homo sapiens].
ACCESSION   XP_011519532
VERSION     XP_011519532.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521230.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..613
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..613
                     /product="cytosolic carboxypeptidase 4 isoform X7"
                     /calculated_mol_wt=68495
     CDS             1..613
                     /gene="AGBL1"
                     /gene_synonym="CCP4; FECD8"
                     /coded_by="XM_011521230.4:354..2195"
                     /db_xref="GeneID:123624"
                     /db_xref="HGNC:HGNC:26504"
                     /db_xref="MIM:615496"
ORIGIN      
        1 maeqeasglq vllhtlqsss dkesiltilk vlgdllsvgt drrihymisk ggseallqtl
       61 vdtartappd ydillplfrl lakvglrdkk igrkalelea ldvtlilark nlshgqnllh
      121 clwalrvfas svsmgamlgi ngamellfkv itpytrkrtq airaatevla allksksngr
      181 ravnrgyvts llglhqdwhs hdtanayvqi rrglllclrh iaalrsgrea flaaqgmeil
      241 fsttqncldd ksmepvisvv lqilrqcypt splplvtass ayafpvpgci ttepphdlpe
      301 edfeddgdde vdkdsdtedg kvedddletd vnklsskpgl drpeeelmqy evmclelsys
      361 feelqsklgd dlnsektqya nhhhipaaas skqhcyskdq sscgqereya vqtsllcrvk
      421 tgrstvhlgs kknpgvnlyq nvqsnslrrd sseseipdiq aspkadawdv daifcprmsa
      481 sfsnstrtre vvkvidkllq thlkrvpfhd pylymakarr tssvvdfkmm afpdvwghcp
      541 ppttqpmler kcgvqririf edirrliqps dvinkvvfsl depwplqdna snclrffskf
      601 esgnlrkaiq vrv
//
LOCUS       XP_005272478             596 aa            linear   PRI 05-AUG-2025
DEFINITION  WASP homolog-associated protein with actin, membranes and
            microtubules isoform X1 [Homo sapiens].
ACCESSION   XP_005272478
VERSION     XP_005272478.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005272421.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..596
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..596
                     /product="WASP homolog-associated protein with actin,
                     membranes and microtubules isoform X1"
                     /calculated_mol_wt=67759
     Region          <1..229
                     /region_name="JMY"
                     /note="Junction-mediating and -regulatory protein;
                     pfam15871"
                     /db_xref="CDD:464915"
     CDS             1..596
                     /gene="WHAMM"
                     /gene_synonym="WHAMM1; WHDC1"
                     /coded_by="XM_005272421.5:279..2069"
                     /db_xref="GeneID:123720"
                     /db_xref="HGNC:HGNC:30493"
                     /db_xref="MIM:612393"
ORIGIN      
        1 mvalmnvyqe edeayqelvt vatmffqyll qpframreva tlckldilks ldeddlgprr
       61 vvalekeaee wtrraeeavv siqditvnyf ketvkalagm qkemeqdakr fgqaawatai
      121 prleklqlml aretlqlmra kelclnhkra eiqgkmedlp eqekntnvvd eleiqfyeiq
      181 lelyevkfei lkneeilltt qldslkrlik ekqdevvyyd pcenpeelkv idcvvglqdd
      241 knlevkelrr qcqqleskrg ricakraslr srkdqckenh rfrlqqaees irysrqhhsi
      301 qmkrdkikee eqkkkewinq erqktlqrlr sfkdkrlaqs vrntsgsepv apnlpsdlsq
      361 qmclpashav svihpssrkt rgvplseagn vkspkcqnch gnipvqvfvp vgdqthskss
      421 eelslppppp pppppppppp ppppplrals sssqaathqn lgfrapvkdd qprplvcesp
      481 aerprdsles fscpgsmdev laslrhgrap lrkvevpavr pphasinehi laairqgvkl
      541 kkvhpdlgpn psskptsnrr tsdlersika alqrikrvsa dseedsdeqd pgqwdg
//
LOCUS       XP_005272480             579 aa            linear   PRI 05-AUG-2025
DEFINITION  WASP homolog-associated protein with actin, membranes and
            microtubules isoform X2 [Homo sapiens].
ACCESSION   XP_005272480
VERSION     XP_005272480.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005272423.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..579
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..579
                     /product="WASP homolog-associated protein with actin,
                     membranes and microtubules isoform X2"
                     /calculated_mol_wt=65793
     Region          <27..212
                     /region_name="JMY"
                     /note="Junction-mediating and -regulatory protein;
                     pfam15871"
                     /db_xref="CDD:464915"
     CDS             1..579
                     /gene="WHAMM"
                     /gene_synonym="WHAMM1; WHDC1"
                     /coded_by="XM_005272423.5:314..2053"
                     /db_xref="GeneID:123720"
                     /db_xref="HGNC:HGNC:30493"
                     /db_xref="MIM:612393"
ORIGIN      
        1 mkhtrnwlpw qpcssstycs hlglceklql yksldeddlg prrvvaleke aeewtrraee
       61 avvsiqditv nyfketvkal agmqkemeqd akrfgqaawa taiprleklq lmlaretlql
      121 mrakelclnh kraeiqgkme dlpeqekntn vvdeleiqfy eiqlelyevk feilkneeil
      181 lttqldslkr likekqdevv yydpcenpee lkvidcvvgl qddknlevke lrrqcqqles
      241 krgricakra slrsrkdqck enhrfrlqqa eesirysrqh hsiqmkrdki keeeqkkkew
      301 inqerqktlq rlrsfkdkrl aqsvrntsgs epvapnlpsd lsqqmclpas havsvihpss
      361 rktrgvplse agnvkspkcq nchgnipvqv fvpvgdqths ksseelslpp pppppppppp
      421 pppppppplr alssssqaat hqnlgfrapv kddqprplvc espaerprds lesfscpgsm
      481 devlaslrhg raplrkvevp avrpphasin ehilaairqg vklkkvhpdl gpnpsskpts
      541 nrrtsdlers ikaalqrikr vsadseedsd eqdpgqwdg
//
LOCUS       XP_011519534             536 aa            linear   PRI 05-AUG-2025
DEFINITION  WASP homolog-associated protein with actin, membranes and
            microtubules isoform X3 [Homo sapiens].
ACCESSION   XP_011519534
VERSION     XP_011519534.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521232.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..536
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..536
                     /product="WASP homolog-associated protein with actin,
                     membranes and microtubules isoform X3"
                     /calculated_mol_wt=60943
     Region          <39..169
                     /region_name="JMY"
                     /note="Junction-mediating and -regulatory protein;
                     pfam15871"
                     /db_xref="CDD:464915"
     CDS             1..536
                     /gene="WHAMM"
                     /gene_synonym="WHAMM1; WHDC1"
                     /coded_by="XM_011521232.4:710..2320"
                     /db_xref="GeneID:123720"
                     /db_xref="HGNC:HGNC:30493"
                     /db_xref="MIM:612393"
ORIGIN      
        1 mmilvlwsny pyepvclarh rnnmeasvpk ykkqlpqlgm qkemeqdakr fgqaawatai
       61 prleklqlml aretlqlmra kelclnhkra eiqgkmedlp eqekntnvvd eleiqfyeiq
      121 lelyevkfei lkneeilltt qldslkrlik ekqdevvyyd pcenpeelkv idcvvglqdd
      181 knlevkelrr qcqqleskrg ricakraslr srkdqckenh rfrlqqaees irysrqhhsi
      241 qmkrdkikee eqkkkewinq erqktlqrlr sfkdkrlaqs vrntsgsepv apnlpsdlsq
      301 qmclpashav svihpssrkt rgvplseagn vkspkcqnch gnipvqvfvp vgdqthskss
      361 eelslppppp pppppppppp ppppplrals sssqaathqn lgfrapvkdd qprplvcesp
      421 aerprdsles fscpgsmdev laslrhgrap lrkvevpavr pphasinehi laairqgvkl
      481 kkvhpdlgpn psskptsnrr tsdlersika alqrikrvsa dseedsdeqd pgqwdg
//
LOCUS       XP_047288109             507 aa            linear   PRI 05-AUG-2025
DEFINITION  WASP homolog-associated protein with actin, membranes and
            microtubules isoform X4 [Homo sapiens].
ACCESSION   XP_047288109
VERSION     XP_047288109.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432153.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..507
                     /product="WASP homolog-associated protein with actin,
                     membranes and microtubules isoform X4"
                     /calculated_mol_wt=57080
     Region          5..53
                     /region_name="WHAMM-JMY_N"
                     /note="N-terminal of Junction-mediating and WASP
                     homolog-associated; pfam15920"
                     /db_xref="CDD:464942"
     Region          78..442
                     /region_name="JMY"
                     /note="Junction-mediating and -regulatory protein;
                     pfam15871"
                     /db_xref="CDD:464915"
     CDS             1..507
                     /gene="WHAMM"
                     /gene_synonym="WHAMM1; WHDC1"
                     /coded_by="XM_047432153.1:100..1623"
                     /db_xref="GeneID:123720"
                     /db_xref="HGNC:HGNC:30493"
                     /db_xref="MIM:612393"
ORIGIN      
        1 medeqpdsle gwvpvreglf aeperhrlrf lvawngaegk favtchdrta qqrrlregar
       61 lgpepepkpe aavspsswag llsaaglrga hrqlaalwpp lercfprlpp eldvggggaw
      121 glglglwall wptragpgea alqelcgqle rylgaaadgc ggatvrdalf paeggaadce
      181 sprefreral rarwveadar lrqviqghgk antmvalmnv yqeedeayqe lvtvatmffq
      241 yllqpframr evatlckldi lksldeddlg prrvvaleke aeewtrraee avvsiqditv
      301 nyfketvkal agmqkemeqd akrfgqaawa taiprleklq lmlaretlql mrakelclnh
      361 kraeiqgkme dlpeqekntn vvdeleiqfy eiqlelyevk feilkneeil lttqldslkr
      421 likekqdevv yydpcenpee lkvidcvvgl qddknlevke lrrqcqqles krgricakra
      481 slrsrkvici ippgsvqrks svqiatg
//
LOCUS       XP_047288110             426 aa            linear   PRI 05-AUG-2025
DEFINITION  WASP homolog-associated protein with actin, membranes and
            microtubules isoform X5 [Homo sapiens].
ACCESSION   XP_047288110
VERSION     XP_047288110.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432154.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..426
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..426
                     /product="WASP homolog-associated protein with actin,
                     membranes and microtubules isoform X5"
                     /calculated_mol_wt=47883
     Region          5..53
                     /region_name="WHAMM-JMY_N"
                     /note="N-terminal of Junction-mediating and WASP
                     homolog-associated; pfam15920"
                     /db_xref="CDD:464942"
     Region          78..426
                     /region_name="JMY"
                     /note="Junction-mediating and -regulatory protein;
                     pfam15871"
                     /db_xref="CDD:464915"
     CDS             1..426
                     /gene="WHAMM"
                     /gene_synonym="WHAMM1; WHDC1"
                     /coded_by="XM_047432154.1:100..1380"
                     /db_xref="GeneID:123720"
                     /db_xref="HGNC:HGNC:30493"
                     /db_xref="MIM:612393"
ORIGIN      
        1 medeqpdsle gwvpvreglf aeperhrlrf lvawngaegk favtchdrta qqrrlregar
       61 lgpepepkpe aavspsswag llsaaglrga hrqlaalwpp lercfprlpp eldvggggaw
      121 glglglwall wptragpgea alqelcgqle rylgaaadgc ggatvrdalf paeggaadce
      181 sprefreral rarwveadar lrqviqghgk antmvalmnv yqeedeayqe lvtvatmffq
      241 yllqpframr evatlckldi lksldeddlg prrvvaleke aeewtrraee avvsiqditv
      301 nyfketvkal agmqkemeqd akrfgqaawa taiprleklq lmlaretlql mrakelclnh
      361 kraeiqgkme dlpeqekntn vvdeleiqfy eiqlelyevk feilkneeil lttqldslkr
      421 likdei
//
LOCUS       XP_024305612             749 aa            linear   PRI 05-AUG-2025
DEFINITION  fibronectin type III and SPRY domain-containing protein 2 isoform
            X1 [Homo sapiens].
ACCESSION   XP_024305612
VERSION     XP_024305612.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449844.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..749
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..749
                     /product="fibronectin type III and SPRY domain-containing
                     protein 2 isoform X1"
                     /calculated_mol_wt=85255
     Region          188..>333
                     /region_name="PRK12704"
                     /note="phosphodiesterase; Provisional"
                     /db_xref="CDD:237177"
     Region          <371..>561
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     Region          372..457
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; smart00060"
                     /db_xref="CDD:214495"
     Site            order(372,440,455)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Site            order(456..457,459..460)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          565..740
                     /region_name="SPRY_PRY_TRIM76_like"
                     /note="PRY/SPRY domain in tripartite motif-containing
                     protein 76 (TRIM76)-like; cd12899"
                     /db_xref="CDD:293956"
     CDS             1..749
                     /gene="FSD2"
                     /gene_synonym="SPRYD1"
                     /coded_by="XM_024449844.2:291..2540"
                     /db_xref="GeneID:123722"
                     /db_xref="HGNC:HGNC:18024"
ORIGIN      
        1 meeesgeelg ldrstpkdfh fyhmdlydse drlhlfpeen trmrkvvqae manesrgagd
       61 gkaqrdlqee vdelvhlygl eddhelgdef vdeniprtgv seyppymmkr rdpareqrdw
      121 rlsgeaaeae dlgfggwgsa gqcqdlreay rythgrasee yecyvipeee deeeaadvfc
      181 vtcktpiraf qkvfdehkeh eviplneale sakdeihknm yklekqiiem enfanhleev
      241 fitveenfgk qeqnfeshyn eiletlaqky eekiqalgek kkeklealyg qlvscgenld
      301 tckelmetie emcheekvdf ikdavamadr lgkflktktd veisaqpefe dqtldfsdve
      361 qlmgsintip apsapvinpq vpnsatgssv rvcwslysdd tvesyqlsyr pvqdsspgtd
      421 qaeftvtvke tycsvtnlvp ntqyefwvta hnragpspss eravymtaps ppiiktkeir
      481 sceeavlicw esgnlnpvds ytveltqaes peasgvtesv vgiptcesvv qlqpgrsyii
      541 yvralnmggp svrsepatvh tigsyfrlnk dtchpwltis edgltavrse rrtparelsp
      601 sdthftrcva vmgnlipvrg hhywevevde hldyrvgvaf advrkqedlg anclswcmrh
      661 tfassrhkye flhnrttpdi ritvppkkig illdyehskl sffnvdlsqh lytfscqlhe
      721 fvhpcfslek pgclkvhngi smpkhvtfy
//
LOCUS       XP_005272482             749 aa            linear   PRI 05-AUG-2025
DEFINITION  fibronectin type III and SPRY domain-containing protein 2 isoform
            X1 [Homo sapiens].
ACCESSION   XP_005272482
VERSION     XP_005272482.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005272425.6
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..749
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..749
                     /product="fibronectin type III and SPRY domain-containing
                     protein 2 isoform X1"
                     /calculated_mol_wt=85255
     Region          188..>333
                     /region_name="PRK12704"
                     /note="phosphodiesterase; Provisional"
                     /db_xref="CDD:237177"
     Region          <371..>561
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     Region          372..457
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; smart00060"
                     /db_xref="CDD:214495"
     Site            order(372,440,455)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Site            order(456..457,459..460)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          565..740
                     /region_name="SPRY_PRY_TRIM76_like"
                     /note="PRY/SPRY domain in tripartite motif-containing
                     protein 76 (TRIM76)-like; cd12899"
                     /db_xref="CDD:293956"
     CDS             1..749
                     /gene="FSD2"
                     /gene_synonym="SPRYD1"
                     /coded_by="XM_005272425.6:300..2549"
                     /db_xref="GeneID:123722"
                     /db_xref="HGNC:HGNC:18024"
ORIGIN      
        1 meeesgeelg ldrstpkdfh fyhmdlydse drlhlfpeen trmrkvvqae manesrgagd
       61 gkaqrdlqee vdelvhlygl eddhelgdef vdeniprtgv seyppymmkr rdpareqrdw
      121 rlsgeaaeae dlgfggwgsa gqcqdlreay rythgrasee yecyvipeee deeeaadvfc
      181 vtcktpiraf qkvfdehkeh eviplneale sakdeihknm yklekqiiem enfanhleev
      241 fitveenfgk qeqnfeshyn eiletlaqky eekiqalgek kkeklealyg qlvscgenld
      301 tckelmetie emcheekvdf ikdavamadr lgkflktktd veisaqpefe dqtldfsdve
      361 qlmgsintip apsapvinpq vpnsatgssv rvcwslysdd tvesyqlsyr pvqdsspgtd
      421 qaeftvtvke tycsvtnlvp ntqyefwvta hnragpspss eravymtaps ppiiktkeir
      481 sceeavlicw esgnlnpvds ytveltqaes peasgvtesv vgiptcesvv qlqpgrsyii
      541 yvralnmggp svrsepatvh tigsyfrlnk dtchpwltis edgltavrse rrtparelsp
      601 sdthftrcva vmgnlipvrg hhywevevde hldyrvgvaf advrkqedlg anclswcmrh
      661 tfassrhkye flhnrttpdi ritvppkkig illdyehskl sffnvdlsqh lytfscqlhe
      721 fvhpcfslek pgclkvhngi smpkhvtfy
//
LOCUS       XP_024305613             749 aa            linear   PRI 05-AUG-2025
DEFINITION  fibronectin type III and SPRY domain-containing protein 2 isoform
            X1 [Homo sapiens].
ACCESSION   XP_024305613
VERSION     XP_024305613.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449845.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..749
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..749
                     /product="fibronectin type III and SPRY domain-containing
                     protein 2 isoform X1"
                     /calculated_mol_wt=85255
     Region          188..>333
                     /region_name="PRK12704"
                     /note="phosphodiesterase; Provisional"
                     /db_xref="CDD:237177"
     Region          <371..>561
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     Region          372..457
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; smart00060"
                     /db_xref="CDD:214495"
     Site            order(372,440,455)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Site            order(456..457,459..460)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          565..740
                     /region_name="SPRY_PRY_TRIM76_like"
                     /note="PRY/SPRY domain in tripartite motif-containing
                     protein 76 (TRIM76)-like; cd12899"
                     /db_xref="CDD:293956"
     CDS             1..749
                     /gene="FSD2"
                     /gene_synonym="SPRYD1"
                     /coded_by="XM_024449845.2:150..2399"
                     /db_xref="GeneID:123722"
                     /db_xref="HGNC:HGNC:18024"
ORIGIN      
        1 meeesgeelg ldrstpkdfh fyhmdlydse drlhlfpeen trmrkvvqae manesrgagd
       61 gkaqrdlqee vdelvhlygl eddhelgdef vdeniprtgv seyppymmkr rdpareqrdw
      121 rlsgeaaeae dlgfggwgsa gqcqdlreay rythgrasee yecyvipeee deeeaadvfc
      181 vtcktpiraf qkvfdehkeh eviplneale sakdeihknm yklekqiiem enfanhleev
      241 fitveenfgk qeqnfeshyn eiletlaqky eekiqalgek kkeklealyg qlvscgenld
      301 tckelmetie emcheekvdf ikdavamadr lgkflktktd veisaqpefe dqtldfsdve
      361 qlmgsintip apsapvinpq vpnsatgssv rvcwslysdd tvesyqlsyr pvqdsspgtd
      421 qaeftvtvke tycsvtnlvp ntqyefwvta hnragpspss eravymtaps ppiiktkeir
      481 sceeavlicw esgnlnpvds ytveltqaes peasgvtesv vgiptcesvv qlqpgrsyii
      541 yvralnmggp svrsepatvh tigsyfrlnk dtchpwltis edgltavrse rrtparelsp
      601 sdthftrcva vmgnlipvrg hhywevevde hldyrvgvaf advrkqedlg anclswcmrh
      661 tfassrhkye flhnrttpdi ritvppkkig illdyehskl sffnvdlsqh lytfscqlhe
      721 fvhpcfslek pgclkvhngi smpkhvtfy
//
LOCUS       XP_011519537             672 aa            linear   PRI 05-AUG-2025
DEFINITION  fibronectin type III and SPRY domain-containing protein 2 isoform
            X2 [Homo sapiens].
ACCESSION   XP_011519537
VERSION     XP_011519537.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521235.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..672
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..672
                     /product="fibronectin type III and SPRY domain-containing
                     protein 2 isoform X2"
                     /calculated_mol_wt=76198
     Region          <178..205
                     /region_name="Bbox_SF"
                     /note="B-box-type zinc finger superfamily; cl00034"
                     /db_xref="CDD:469587"
     Region          <294..>484
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     Region          295..380
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; smart00060"
                     /db_xref="CDD:214495"
     Site            order(295,363,378)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Site            order(379..380,382..383)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          488..663
                     /region_name="SPRY_PRY_TRIM76_like"
                     /note="PRY/SPRY domain in tripartite motif-containing
                     protein 76 (TRIM76)-like; cd12899"
                     /db_xref="CDD:293956"
     CDS             1..672
                     /gene="FSD2"
                     /gene_synonym="SPRYD1"
                     /coded_by="XM_011521235.4:300..2318"
                     /db_xref="GeneID:123722"
                     /db_xref="HGNC:HGNC:18024"
ORIGIN      
        1 meeesgeelg ldrstpkdfh fyhmdlydse drlhlfpeen trmrkvvqae manesrgagd
       61 gkaqrdlqee vdelvhlygl eddhelgdef vdeniprtgv seyppymmkr rdpareqrdw
      121 rlsgeaaeae dlgfggwgsa gqcqdlreay rythgrasee yecyvipeee deeeaadvfc
      181 vtcktpiraf qkvfdehkeh eviplneale sakdeihknm yklekqiiem enfanhleev
      241 fitvedavam adrlgkflkt ktdveisaqp efedqtldfs dveqlmgsin tipapsapvi
      301 npqvpnsatg ssvrvcwsly sddtvesyql syrpvqdssp gtdqaeftvt vketycsvtn
      361 lvpntqyefw vtahnragps psseravymt apsppiiktk eirsceeavl icwesgnlnp
      421 vdsytveltq aespeasgvt esvvgiptce svvqlqpgrs yiiyvralnm ggpsvrsepa
      481 tvhtigsyfr lnkdtchpwl tisedgltav rserrtpare lspsdthftr cvavmgnlip
      541 vrghhyweve vdehldyrvg vafadvrkqe dlganclswc mrhtfassrh kyeflhnrtt
      601 pdiritvppk kigilldyeh sklsffnvdl sqhlytfscq lhefvhpcfs lekpgclkvh
      661 ngismpkhvt fy
//
LOCUS       XP_047288112             456 aa            linear   PRI 05-AUG-2025
DEFINITION  fibronectin type III and SPRY domain-containing protein 2 isoform
            X3 [Homo sapiens].
ACCESSION   XP_047288112
VERSION     XP_047288112.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432156.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..456
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..456
                     /product="fibronectin type III and SPRY domain-containing
                     protein 2 isoform X3"
                     /calculated_mol_wt=51814
     Region          188..>333
                     /region_name="PRK12704"
                     /note="phosphodiesterase; Provisional"
                     /db_xref="CDD:237177"
     CDS             1..456
                     /gene="FSD2"
                     /gene_synonym="SPRYD1"
                     /coded_by="XM_047432156.1:300..1670"
                     /db_xref="GeneID:123722"
                     /db_xref="HGNC:HGNC:18024"
ORIGIN      
        1 meeesgeelg ldrstpkdfh fyhmdlydse drlhlfpeen trmrkvvqae manesrgagd
       61 gkaqrdlqee vdelvhlygl eddhelgdef vdeniprtgv seyppymmkr rdpareqrdw
      121 rlsgeaaeae dlgfggwgsa gqcqdlreay rythgrasee yecyvipeee deeeaadvfc
      181 vtcktpiraf qkvfdehkeh eviplneale sakdeihknm yklekqiiem enfanhleev
      241 fitveenfgk qeqnfeshyn eiletlaqky eekiqalgek kkeklealyg qlvscgenld
      301 tckelmetie emcheekvdf ikdavamadr lgkflktktd veisaqpefe dqtldfsdve
      361 qlmgsintip apsapvinpq vpnsatgssv rvcwslysdd tvesyqlsyr pvqdsspgtd
      421 qagllwasrp aspwcscsrg gatlsmceps iwgapa
//
LOCUS       XP_016877413             433 aa            linear   PRI 05-AUG-2025
DEFINITION  fibronectin type III and SPRY domain-containing protein 2 isoform
            X4 [Homo sapiens].
ACCESSION   XP_016877413
VERSION     XP_016877413.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021924.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..433
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..433
                     /product="fibronectin type III and SPRY domain-containing
                     protein 2 isoform X4"
                     /calculated_mol_wt=49350
     Region          188..>333
                     /region_name="PRK12704"
                     /note="phosphodiesterase; Provisional"
                     /db_xref="CDD:237177"
     CDS             1..433
                     /gene="FSD2"
                     /gene_synonym="SPRYD1"
                     /coded_by="XM_017021924.3:300..1601"
                     /db_xref="GeneID:123722"
                     /db_xref="HGNC:HGNC:18024"
ORIGIN      
        1 meeesgeelg ldrstpkdfh fyhmdlydse drlhlfpeen trmrkvvqae manesrgagd
       61 gkaqrdlqee vdelvhlygl eddhelgdef vdeniprtgv seyppymmkr rdpareqrdw
      121 rlsgeaaeae dlgfggwgsa gqcqdlreay rythgrasee yecyvipeee deeeaadvfc
      181 vtcktpiraf qkvfdehkeh eviplneale sakdeihknm yklekqiiem enfanhleev
      241 fitveenfgk qeqnfeshyn eiletlaqky eekiqalgek kkeklealyg qlvscgenld
      301 tckelmetie emcheekvdf ikdavamadr lgkflktktd veisaqpefe dqtldfsdve
      361 qlmgsintip apsapvinpq vpnsatgssv rvcwslysdd tvesyqlsyr pvqdsspgtd
      421 qadhagggls srs
//
LOCUS       XP_047288114             612 aa            linear   PRI 05-AUG-2025
DEFINITION  cytosolic phospholipase A2 epsilon isoform X1 [Homo sapiens].
ACCESSION   XP_047288114
VERSION     XP_047288114.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432158.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..612
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..612
                     /product="cytosolic phospholipase A2 epsilon isoform X1"
                     /calculated_mol_wt=69058
     Region          40..148
                     /region_name="C2_cPLA2"
                     /note="C2 domain present in cytosolic PhosphoLipase A2
                     (cPLA2); cd04036"
                     /db_xref="CDD:176001"
     Site            order(58,61,83,111,113)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:176001"
     Region          180..292
                     /region_name="cPLA2_C2"
                     /note="Cytosolic phospholipases A2 C2-domain; pfam18695"
                     /db_xref="CDD:465834"
     Region          291..>551
                     /region_name="Patatin_and_cPLA2"
                     /note="Patatins and Phospholipases; cl11396"
                     /db_xref="CDD:416256"
     Site            order(352..353,355,383)
                     /site_type="active"
                     /db_xref="CDD:132836"
     Site            381..385
                     /site_type="other"
                     /note="nucleophile elbow"
                     /db_xref="CDD:132836"
     CDS             1..612
                     /gene="PLA2G4E"
                     /coded_by="XM_047432158.1:13..1851"
                     /db_xref="GeneID:123745"
                     /db_xref="HGNC:HGNC:24791"
                     /db_xref="MIM:620649"
ORIGIN      
        1 mllrqmharv shslpdpcqa edsrpsatca lkeglspchl ltvrvirmkn vrqadmlsqt
       61 dcfvslwlpt asqkklrtrt isncpnpewn esfnfqiqsr vknvlelsvc dedtvtpddh
      121 lltvlydltk lcfrkkthvk fplnpqgmee levefllees psppetlvtn gvlvsrqvsc
      181 levhaqsrrr rkrekmkdll vmvnesfent qrvrpclepc cptsacfqta acfhypkyfq
      241 sqvhvevpks hwscglccrs rkkgpisqpl dclsdgqvmt lpvgesyelh mkstpcpetl
      301 dvrlgfslcp aeleflqkrk vvvakalkqv lqleedlqed evpliaimat gggtrsmtsm
      361 yghllglqkl nlldcasyit glsgatwtma tlyrdpdwss knlepaifea rrhvvkdklp
      421 slfpdqlrkf qeelrqrsqe gyrvtftdfw gllietclgd ernecklsdq raalscgqnp
      481 lpiyltinvk ddvsnqdfre wfefspyevg lqkygafips elfgseffmg rlvkripesr
      541 icymlasass vpasrgqprp gtrgsrettg pveqhllpep agclepvthl ggvfpqvdkg
      601 esaghrrrad pa
//
LOCUS       XP_047288115             525 aa            linear   PRI 05-AUG-2025
DEFINITION  cytosolic phospholipase A2 epsilon isoform X2 [Homo sapiens].
ACCESSION   XP_047288115
VERSION     XP_047288115.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432159.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..525
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..525
                     /product="cytosolic phospholipase A2 epsilon isoform X2"
                     /calculated_mol_wt=59117
     Region          40..148
                     /region_name="C2_cPLA2"
                     /note="C2 domain present in cytosolic PhosphoLipase A2
                     (cPLA2); cd04036"
                     /db_xref="CDD:176001"
     Site            order(58,61,83,111,113)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:176001"
     Region          180..292
                     /region_name="cPLA2_C2"
                     /note="Cytosolic phospholipases A2 C2-domain; pfam18695"
                     /db_xref="CDD:465834"
     Region          291..>492
                     /region_name="Patatin_and_cPLA2"
                     /note="Patatins and Phospholipases; cl11396"
                     /db_xref="CDD:416256"
     Site            order(352..353,355,383)
                     /site_type="active"
                     /db_xref="CDD:132836"
     Site            381..385
                     /site_type="other"
                     /note="nucleophile elbow"
                     /db_xref="CDD:132836"
     CDS             1..525
                     /gene="PLA2G4E"
                     /coded_by="XM_047432159.1:13..1590"
                     /db_xref="GeneID:123745"
                     /db_xref="HGNC:HGNC:24791"
                     /db_xref="MIM:620649"
ORIGIN      
        1 mllrqmharv shslpdpcqa edsrpsatca lkeglspchl ltvrvirmkn vrqadmlsqt
       61 dcfvslwlpt asqkklrtrt isncpnpewn esfnfqiqsr vknvlelsvc dedtvtpddh
      121 lltvlydltk lcfrkkthvk fplnpqgmee levefllees psppetlvtn gvlvsrqvsc
      181 levhaqsrrr rkrekmkdll vmvnesfent qrvrpclepc cptsacfqta acfhypkyfq
      241 sqvhvevpks hwscglccrs rkkgpisqpl dclsdgqvmt lpvgesyelh mkstpcpetl
      301 dvrlgfslcp aeleflqkrk vvvakalkqv lqleedlqed evpliaimat gggtrsmtsm
      361 yghllglqkl nlldcasyit glsgatwtma tlyrdpdwss knlepaifea rrhvvkdklp
      421 slfpdqlrkf qeelrqrsqe gyrvtftdfw gllietclgd ernecklsdq raalscgqnp
      481 lpiyltinvk ddsgsssppt rwacrsmgps sppsssapss swggw
//
LOCUS       XP_047288116             525 aa            linear   PRI 05-AUG-2025
DEFINITION  cytosolic phospholipase A2 epsilon isoform X2 [Homo sapiens].
ACCESSION   XP_047288116
VERSION     XP_047288116.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432160.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..525
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..525
                     /product="cytosolic phospholipase A2 epsilon isoform X2"
                     /calculated_mol_wt=59117
     Region          40..148
                     /region_name="C2_cPLA2"
                     /note="C2 domain present in cytosolic PhosphoLipase A2
                     (cPLA2); cd04036"
                     /db_xref="CDD:176001"
     Site            order(58,61,83,111,113)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:176001"
     Region          180..292
                     /region_name="cPLA2_C2"
                     /note="Cytosolic phospholipases A2 C2-domain; pfam18695"
                     /db_xref="CDD:465834"
     Region          291..>492
                     /region_name="Patatin_and_cPLA2"
                     /note="Patatins and Phospholipases; cl11396"
                     /db_xref="CDD:416256"
     Site            order(352..353,355,383)
                     /site_type="active"
                     /db_xref="CDD:132836"
     Site            381..385
                     /site_type="other"
                     /note="nucleophile elbow"
                     /db_xref="CDD:132836"
     CDS             1..525
                     /gene="PLA2G4E"
                     /coded_by="XM_047432160.1:13..1590"
                     /db_xref="GeneID:123745"
                     /db_xref="HGNC:HGNC:24791"
                     /db_xref="MIM:620649"
ORIGIN      
        1 mllrqmharv shslpdpcqa edsrpsatca lkeglspchl ltvrvirmkn vrqadmlsqt
       61 dcfvslwlpt asqkklrtrt isncpnpewn esfnfqiqsr vknvlelsvc dedtvtpddh
      121 lltvlydltk lcfrkkthvk fplnpqgmee levefllees psppetlvtn gvlvsrqvsc
      181 levhaqsrrr rkrekmkdll vmvnesfent qrvrpclepc cptsacfqta acfhypkyfq
      241 sqvhvevpks hwscglccrs rkkgpisqpl dclsdgqvmt lpvgesyelh mkstpcpetl
      301 dvrlgfslcp aeleflqkrk vvvakalkqv lqleedlqed evpliaimat gggtrsmtsm
      361 yghllglqkl nlldcasyit glsgatwtma tlyrdpdwss knlepaifea rrhvvkdklp
      421 slfpdqlrkf qeelrqrsqe gyrvtftdfw gllietclgd ernecklsdq raalscgqnp
      481 lpiyltinvk ddsgsssppt rwacrsmgps sppsssapss swggw
//
LOCUS       XP_011519540             492 aa            linear   PRI 05-AUG-2025
DEFINITION  cytosolic phospholipase A2 epsilon isoform X3 [Homo sapiens].
ACCESSION   XP_011519540
VERSION     XP_011519540.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521238.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..492
                     /product="cytosolic phospholipase A2 epsilon isoform X3"
                     /calculated_mol_wt=56585
     Region          1..487
                     /region_name="Patatin_and_cPLA2"
                     /note="Patatins and Phospholipases; cl11396"
                     /db_xref="CDD:416256"
     Site            order(5..6,8,36,324)
                     /site_type="active"
                     /db_xref="CDD:132836"
     Site            34..38
                     /site_type="other"
                     /note="nucleophile elbow"
                     /db_xref="CDD:132836"
     CDS             1..492
                     /gene="PLA2G4E"
                     /coded_by="XM_011521238.2:847..2325"
                     /db_xref="GeneID:123745"
                     /db_xref="HGNC:HGNC:24791"
                     /db_xref="MIM:620649"
ORIGIN      
        1 matgggtrsm tsmyghllgl qklnlldcas yitglsgatw tmatlyrdpd wssknlepai
       61 fearrhvvkd klpslfpdql rkfqeelrqr sqegyrvtft dfwgllietc lgderneckl
      121 sdqraalscg qnplpiylti nvkddvsnqd frewfefspy evglqkygaf ipselfgsef
      181 fmgrlvkrip esricymlgl wssifslnll dawnlshtse effhrwtrek vqdiedepil
      241 peipkcdani lettvvipgs wlsnsfreil thrsfvsefh nflsglqlht nylqngqfsr
      301 wkdtvldgfp nqltesanhl clldtaffvn ssyppllrpe rkadliihln ycagsqtkpl
      361 kqtceyctvq nipfpkyelp denenlkecy lmenpqepda pivtffplin dtfrkykapg
      421 verspeeleq gqvdiygpkt pyatkeltyt eatfdklvkl seynilnnkd tllqalrlav
      481 ekkkrlkgqc ps
//
LOCUS       XP_011519541             453 aa            linear   PRI 05-AUG-2025
DEFINITION  cytosolic phospholipase A2 epsilon isoform X4 [Homo sapiens].
ACCESSION   XP_011519541
VERSION     XP_011519541.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521239.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..453
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..453
                     /product="cytosolic phospholipase A2 epsilon isoform X4"
                     /calculated_mol_wt=52556
     Region          2..448
                     /region_name="Patatin_and_cPLA2"
                     /note="Patatins and Phospholipases; cl11396"
                     /db_xref="CDD:416256"
     CDS             1..453
                     /gene="PLA2G4E"
                     /coded_by="XM_011521239.2:92..1453"
                     /db_xref="GeneID:123745"
                     /db_xref="HGNC:HGNC:24791"
                     /db_xref="MIM:620649"
ORIGIN      
        1 mtmatlyrdp dwssknlepa ifearrhvvk dklpslfpdq lrkfqeelrq rsqegyrvtf
       61 tdfwglliet clgderneck lsdqraalsc gqnplpiylt invkddvsnq dfrewfefsp
      121 yevglqkyga fipselfgse ffmgrlvkri pesricymlg lwssifslnl ldawnlshts
      181 eeffhrwtre kvqdiedepi lpeipkcdan ilettvvipg swlsnsfrei lthrsfvsef
      241 hnflsglqlh tnylqngqfs rwkdtvldgf pnqltesanh lclldtaffv nssyppllrp
      301 erkadliihl nycagsqtkp lkqtceyctv qnipfpkyel pdenenlkec ylmenpqepd
      361 apivtffpli ndtfrkykap gverspeele qgqvdiygpk tpyatkelty teatfdklvk
      421 lseynilnnk dtllqalrla vekkkrlkgq cps
//
LOCUS       XP_011519542             126 aa            linear   PRI 05-AUG-2025
DEFINITION  telomere repeats-binding bouquet formation protein 2 isoform X1
            [Homo sapiens].
ACCESSION   XP_011519542
VERSION     XP_011519542.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521240.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..126
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..126
                     /product="telomere repeats-binding bouquet formation
                     protein 2 isoform X1"
                     /calculated_mol_wt=14268
     Region          2..>116
                     /region_name="TERB2"
                     /note="Telomere-associated protein TERB2; pfam15101"
                     /db_xref="CDD:464503"
     CDS             1..126
                     /gene="TERB2"
                     /gene_synonym="C15orf43; SPGF59"
                     /coded_by="XM_011521240.3:33..413"
                     /db_xref="GeneID:145645"
                     /db_xref="HGNC:HGNC:28520"
                     /db_xref="MIM:617131"
ORIGIN      
        1 mfqgqrgwfc gsvsqdlrqf wvaeggtisd praadflfsc dashpdtlri yqsldyiedn
       61 atvfhayyls avanakikns valghfilpp aclqkeirrk igsfiweqdq hfliekmepr
      121 svarve
//
LOCUS       XP_047288119             296 aa            linear   PRI 05-AUG-2025
DEFINITION  lysM and putative peptidoglycan-binding domain-containing protein 4
            isoform X1 [Homo sapiens].
ACCESSION   XP_047288119
VERSION     XP_047288119.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432163.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..296
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..296
                     /product="lysM and putative peptidoglycan-binding
                     domain-containing protein 4 isoform X1"
                     /calculated_mol_wt=31935
     Region          80..118
                     /region_name="LysM"
                     /note="Lysin motif; smart00257"
                     /db_xref="CDD:197609"
     CDS             1..296
                     /gene="LYSMD4"
                     /coded_by="XM_047432163.1:1439..2329"
                     /db_xref="GeneID:145748"
                     /db_xref="HGNC:HGNC:26571"
ORIGIN      
        1 mrheelltkt fqgpavvcgt ptshvymfkn gsgdsgdsse eeshrvvlrp rgkerhksgv
       61 hqppqagagd vvllqrelaq edslnklalq ygckvadikk vnnfireqdl yalksvkipv
      121 rnhgilmeth kelkpllsps settvtvelp eadragagtg aqagqlmgff kgidqdiera
      181 vqseiflhes ycmdtshqpl lpappktpmd gadcgiqwwn avfimlligi vlpvfylvyf
      241 kiqasgetpn slnttvipng smamgtvpgq aprlavavpa vtsadsqfsq ttqags
//
LOCUS       XP_011519543             204 aa            linear   PRI 05-AUG-2025
DEFINITION  lysM and putative peptidoglycan-binding domain-containing protein 4
            isoform X2 [Homo sapiens].
ACCESSION   XP_011519543
VERSION     XP_011519543.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521241.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XP_011519543.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..204
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..204
                     /product="lysM and putative peptidoglycan-binding
                     domain-containing protein 4 isoform X2"
                     /calculated_mol_wt=21841
     CDS             1..204
                     /gene="LYSMD4"
                     /coded_by="XM_011521241.2:148..762"
                     /db_xref="GeneID:145748"
                     /db_xref="HGNC:HGNC:26571"
ORIGIN      
        1 mavadikkvn nfireqdlya lksvkipvrn hgilmethke lkpllspsse ttvtvelpea
       61 dragagtgaq agqlmgffkg idqdieravq seiflhesyc mdtshqpllp appktpmdga
      121 dcgiqwwnav fimlligivl pvfylvyfki qasgetpnsl nttvipngsm amgtvpgqap
      181 rlavavpavt sadsqfsqtt qags
//
LOCUS       XP_011519544             235 aa            linear   PRI 05-AUG-2025
DEFINITION  lysM and putative peptidoglycan-binding domain-containing protein 4
            isoform X3 [Homo sapiens].
ACCESSION   XP_011519544
VERSION     XP_011519544.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521242.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..235
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..235
                     /product="lysM and putative peptidoglycan-binding
                     domain-containing protein 4 isoform X3"
                     /calculated_mol_wt=25656
     Region          80..118
                     /region_name="LysM"
                     /note="Lysin motif; smart00257"
                     /db_xref="CDD:197609"
     CDS             1..235
                     /gene="LYSMD4"
                     /coded_by="XM_011521242.4:909..1616"
                     /db_xref="GeneID:145748"
                     /db_xref="HGNC:HGNC:26571"
ORIGIN      
        1 mrheelltkt fqgpavvcgt ptshvymfkn gsgdsgdsse eeshrvvlrp rgkerhksgv
       61 hqppqagagd vvllqrelaq edslnklalq ygckvadikk vnnfireqdl yalksvkipv
      121 rnhgilmeth kelkpllsps settvtvelp eadragagtg aqagqlmgff kgidqdiera
      181 vqseiflhes ycmdtshqpl lpappktpmd gadcgiqwwn avfimlliaa falvs
//
LOCUS       XP_011519545             231 aa            linear   PRI 05-AUG-2025
DEFINITION  lysM and putative peptidoglycan-binding domain-containing protein 4
            isoform X4 [Homo sapiens].
ACCESSION   XP_011519545
VERSION     XP_011519545.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521243.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..231
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..231
                     /product="lysM and putative peptidoglycan-binding
                     domain-containing protein 4 isoform X4"
                     /calculated_mol_wt=25295
     Region          80..118
                     /region_name="LysM"
                     /note="Lysin motif; smart00257"
                     /db_xref="CDD:197609"
     CDS             1..231
                     /gene="LYSMD4"
                     /coded_by="XM_011521243.4:908..1603"
                     /db_xref="GeneID:145748"
                     /db_xref="HGNC:HGNC:26571"
ORIGIN      
        1 mrheelltkt fqgpavvcgt ptshvymfkn gsgdsgdsse eeshrvvlrp rgkerhksgv
       61 hqppqagagd vvllqrelaq edslnklalq ygckvadikk vnnfireqdl yalksvkipv
      121 rnhgilmeth kelkpllsps settvtvelp eadragagtg aqagqlmgff kgidqdiera
      181 vqseiflhes ycmdtshqpl lpappktpmd gadcgiqwwn avfimlligk i
//
LOCUS       XP_047288120             214 aa            linear   PRI 05-AUG-2025
DEFINITION  lysM and putative peptidoglycan-binding domain-containing protein 4
            isoform X5 [Homo sapiens].
ACCESSION   XP_047288120
VERSION     XP_047288120.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432164.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..214
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..214
                     /product="lysM and putative peptidoglycan-binding
                     domain-containing protein 4 isoform X5"
                     /calculated_mol_wt=23005
     CDS             1..214
                     /gene="LYSMD4"
                     /coded_by="XM_047432164.1:900..1544"
                     /db_xref="GeneID:145748"
                     /db_xref="HGNC:HGNC:26571"
ORIGIN      
        1 mfsafrvinn gkvadikkvn nfireqdlya lksvkipvrn hgilmethke lkpllspsse
       61 ttvtvelpea dragagtgaq agqlmgffkg idqdieravq seiflhesyc mdtshqpllp
      121 appktpmdga dcgiqwwnav fimlligivl pvfylvyfki qasgetpnsl nttvipngsm
      181 amgtvpgqap rlavavpavt sadsqfsqtt qags
//
LOCUS       XP_047288121             203 aa            linear   PRI 05-AUG-2025
DEFINITION  lysM and putative peptidoglycan-binding domain-containing protein 4
            isoform X6 [Homo sapiens].
ACCESSION   XP_047288121
VERSION     XP_047288121.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432165.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..203
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..203
                     /product="lysM and putative peptidoglycan-binding
                     domain-containing protein 4 isoform X6"
                     /calculated_mol_wt=21770
     CDS             1..203
                     /gene="LYSMD4"
                     /coded_by="XM_047432165.1:1491..2102"
                     /db_xref="GeneID:145748"
                     /db_xref="HGNC:HGNC:26571"
ORIGIN      
        1 mvadikkvnn fireqdlyal ksvkipvrnh gilmethkel kpllspsset tvtvelpead
       61 ragagtgaqa gqlmgffkgi dqdieravqs eiflhesycm dtshqpllpa ppktpmdgad
      121 cgiqwwnavf imlligivlp vfylvyfkiq asgetpnsln ttvipngsma mgtvpgqapr
      181 lavavpavts adsqfsqttq ags
//
LOCUS       XP_011519547             174 aa            linear   PRI 05-AUG-2025
DEFINITION  lysM and putative peptidoglycan-binding domain-containing protein 4
            isoform X7 [Homo sapiens].
ACCESSION   XP_011519547
VERSION     XP_011519547.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521245.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..174
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..174
                     /product="lysM and putative peptidoglycan-binding
                     domain-containing protein 4 isoform X7"
                     /calculated_mol_wt=19040
     CDS             1..174
                     /gene="LYSMD4"
                     /coded_by="XM_011521245.4:2..526"
                     /db_xref="GeneID:145748"
                     /db_xref="HGNC:HGNC:26571"
ORIGIN      
        1 mfvanpqarw qlrvagrgsr vagrrsrrsl gaevadikkv nnfireqdly alksvkipvr
       61 nhgilmethk elkpllspss ettvtvelpe adragagtga qagqlmgffk gidqdierav
      121 qseiflhesy cmdtshqpll pappktpmdg adcgiqwwna vfimlliaaf alvs
//
LOCUS       XP_047288122             170 aa            linear   PRI 05-AUG-2025
DEFINITION  lysM and putative peptidoglycan-binding domain-containing protein 4
            isoform X8 [Homo sapiens].
ACCESSION   XP_047288122
VERSION     XP_047288122.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432166.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..170
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..170
                     /product="lysM and putative peptidoglycan-binding
                     domain-containing protein 4 isoform X8"
                     /calculated_mol_wt=17965
     CDS             1..170
                     /gene="LYSMD4"
                     /coded_by="XM_047432166.1:1251..1763"
                     /db_xref="GeneID:145748"
                     /db_xref="HGNC:HGNC:26571"
ORIGIN      
        1 methkelkpl lspssettvt velpeadrag agtgaqagql mgffkgidqd ieravqseif
       61 lhesycmdts hqpllpappk tpmdgadcgi qwwnavfiml ligivlpvfy lvyfkiqasg
      121 etpnslnttv ipngsmamgt vpgqaprlav avpavtsads qfsqttqags
//
LOCUS       XP_047288123             170 aa            linear   PRI 05-AUG-2025
DEFINITION  lysM and putative peptidoglycan-binding domain-containing protein 4
            isoform X9 [Homo sapiens].
ACCESSION   XP_047288123
VERSION     XP_047288123.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432167.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..170
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..170
                     /product="lysM and putative peptidoglycan-binding
                     domain-containing protein 4 isoform X9"
                     /calculated_mol_wt=18679
     CDS             1..170
                     /gene="LYSMD4"
                     /coded_by="XM_047432167.1:2..514"
                     /db_xref="GeneID:145748"
                     /db_xref="HGNC:HGNC:26571"
ORIGIN      
        1 mfvanpqarw qlrvagrgsr vagrrsrrsl gaevadikkv nnfireqdly alksvkipvr
       61 nhgilmethk elkpllspss ettvtvelpe adragagtga qagqlmgffk gidqdierav
      121 qseiflhesy cmdtshqpll pappktpmdg adcgiqwwna vfimlligki
//
LOCUS       XP_016877419             297 aa            linear   PRI 05-AUG-2025
DEFINITION  lysM and putative peptidoglycan-binding domain-containing protein 4
            isoform X10 [Homo sapiens].
ACCESSION   XP_016877419
VERSION     XP_016877419.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021930.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..297
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..297
                     /product="lysM and putative peptidoglycan-binding
                     domain-containing protein 4 isoform X10"
                     /calculated_mol_wt=32177
     CDS             1..297
                     /gene="LYSMD4"
                     /coded_by="XM_017021930.3:994..1887"
                     /db_xref="GeneID:145748"
                     /db_xref="HGNC:HGNC:26571"
ORIGIN      
        1 mavgtrgtll kksltvwfcg pgarsatrav stslprreqv twcccsgswp rrtastswrc
       61 smaantfyfr pngagdtrqn lipdfyafrv inngkvadik kvnnfireqd lyalksvkip
      121 vrnhgilmet hkelkpllsp ssettvtvel peadragagt gaqagqlmgf fkgidqdier
      181 avqseiflhe sycmdtshqp llpappktpm dgadcgiqww navfimllig ivlpvfylvy
      241 fkiqasgetp nslnttvipn gsmamgtvpg qaprlavavp avtsadsqfs qttqags
//
LOCUS       XP_005254223             377 aa            linear   PRI 05-AUG-2025
DEFINITION  protein FAM81A isoform X1 [Homo sapiens].
ACCESSION   XP_005254223
VERSION     XP_005254223.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254166.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..377
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..377
                     /product="protein FAM81A isoform X1"
                     /calculated_mol_wt=43224
     Region          <88..>263
                     /region_name="COG4913"
                     /note="Uncharacterized conserved protein, contains a
                     C-terminal ATPase domain [Function unknown]"
                     /db_xref="CDD:443941"
     Region          166..>372
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..377
                     /gene="FAM81A"
                     /coded_by="XM_005254166.3:119..1252"
                     /db_xref="GeneID:145773"
                     /db_xref="HGNC:HGNC:28379"
ORIGIN      
        1 maqrstvfps rvtkerrvrt mprhsqsltm apyssvslve qledrilche kttaalveha
       61 frikddivns lqkmqnkggg drlarlflee hirnitaivk qlnrdievlq eqirardnis
      121 ygtnsalktl emrqlsglgd lrgrvarcda siarlsaehk ttyeglqhln keqqaaklil
      181 etkikdaegq isqllnrvdl siseqstklk mshrdsnhql qlldtkfkgt veelsnqils
      241 arswlqqeqe riekellqki dqlslivken sgaserdmek klsqmsarld kieegqkktf
      301 dgqrtrqeee kmhgritkle lqmnqnikem kaevnagfta vyesigslrq vleakmkldr
      361 dqlqkqiqlm qkpetpm
//
LOCUS       XP_047288124             377 aa            linear   PRI 05-AUG-2025
DEFINITION  protein FAM81A isoform X1 [Homo sapiens].
ACCESSION   XP_047288124
VERSION     XP_047288124.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432168.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..377
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..377
                     /product="protein FAM81A isoform X1"
                     /calculated_mol_wt=43224
     Region          <88..>263
                     /region_name="COG4913"
                     /note="Uncharacterized conserved protein, contains a
                     C-terminal ATPase domain [Function unknown]"
                     /db_xref="CDD:443941"
     Region          166..>372
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..377
                     /gene="FAM81A"
                     /coded_by="XM_047432168.1:160..1293"
                     /db_xref="GeneID:145773"
                     /db_xref="HGNC:HGNC:28379"
ORIGIN      
        1 maqrstvfps rvtkerrvrt mprhsqsltm apyssvslve qledrilche kttaalveha
       61 frikddivns lqkmqnkggg drlarlflee hirnitaivk qlnrdievlq eqirardnis
      121 ygtnsalktl emrqlsglgd lrgrvarcda siarlsaehk ttyeglqhln keqqaaklil
      181 etkikdaegq isqllnrvdl siseqstklk mshrdsnhql qlldtkfkgt veelsnqils
      241 arswlqqeqe riekellqki dqlslivken sgaserdmek klsqmsarld kieegqkktf
      301 dgqrtrqeee kmhgritkle lqmnqnikem kaevnagfta vyesigslrq vleakmkldr
      361 dqlqkqiqlm qkpetpm
//
LOCUS       XP_011519549             377 aa            linear   PRI 05-AUG-2025
DEFINITION  protein FAM81A isoform X1 [Homo sapiens].
ACCESSION   XP_011519549
VERSION     XP_011519549.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521247.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..377
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..377
                     /product="protein FAM81A isoform X1"
                     /calculated_mol_wt=43224
     Region          <88..>263
                     /region_name="COG4913"
                     /note="Uncharacterized conserved protein, contains a
                     C-terminal ATPase domain [Function unknown]"
                     /db_xref="CDD:443941"
     Region          166..>372
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..377
                     /gene="FAM81A"
                     /coded_by="XM_011521247.3:329..1462"
                     /db_xref="GeneID:145773"
                     /db_xref="HGNC:HGNC:28379"
ORIGIN      
        1 maqrstvfps rvtkerrvrt mprhsqsltm apyssvslve qledrilche kttaalveha
       61 frikddivns lqkmqnkggg drlarlflee hirnitaivk qlnrdievlq eqirardnis
      121 ygtnsalktl emrqlsglgd lrgrvarcda siarlsaehk ttyeglqhln keqqaaklil
      181 etkikdaegq isqllnrvdl siseqstklk mshrdsnhql qlldtkfkgt veelsnqils
      241 arswlqqeqe riekellqki dqlslivken sgaserdmek klsqmsarld kieegqkktf
      301 dgqrtrqeee kmhgritkle lqmnqnikem kaevnagfta vyesigslrq vleakmkldr
      361 dqlqkqiqlm qkpetpm
//
LOCUS       XP_016877420             377 aa            linear   PRI 05-AUG-2025
DEFINITION  protein FAM81A isoform X1 [Homo sapiens].
ACCESSION   XP_016877420
VERSION     XP_016877420.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021931.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..377
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..377
                     /product="protein FAM81A isoform X1"
                     /calculated_mol_wt=43224
     Region          <88..>263
                     /region_name="COG4913"
                     /note="Uncharacterized conserved protein, contains a
                     C-terminal ATPase domain [Function unknown]"
                     /db_xref="CDD:443941"
     Region          166..>372
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..377
                     /gene="FAM81A"
                     /coded_by="XM_017021931.2:600..1733"
                     /db_xref="GeneID:145773"
                     /db_xref="HGNC:HGNC:28379"
ORIGIN      
        1 maqrstvfps rvtkerrvrt mprhsqsltm apyssvslve qledrilche kttaalveha
       61 frikddivns lqkmqnkggg drlarlflee hirnitaivk qlnrdievlq eqirardnis
      121 ygtnsalktl emrqlsglgd lrgrvarcda siarlsaehk ttyeglqhln keqqaaklil
      181 etkikdaegq isqllnrvdl siseqstklk mshrdsnhql qlldtkfkgt veelsnqils
      241 arswlqqeqe riekellqki dqlslivken sgaserdmek klsqmsarld kieegqkktf
      301 dgqrtrqeee kmhgritkle lqmnqnikem kaevnagfta vyesigslrq vleakmkldr
      361 dqlqkqiqlm qkpetpm
//
LOCUS       XP_047288125             377 aa            linear   PRI 05-AUG-2025
DEFINITION  protein FAM81A isoform X1 [Homo sapiens].
ACCESSION   XP_047288125
VERSION     XP_047288125.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432169.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..377
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..377
                     /product="protein FAM81A isoform X1"
                     /calculated_mol_wt=43224
     Region          <88..>263
                     /region_name="COG4913"
                     /note="Uncharacterized conserved protein, contains a
                     C-terminal ATPase domain [Function unknown]"
                     /db_xref="CDD:443941"
     Region          166..>372
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..377
                     /gene="FAM81A"
                     /coded_by="XM_047432169.1:288..1421"
                     /db_xref="GeneID:145773"
                     /db_xref="HGNC:HGNC:28379"
ORIGIN      
        1 maqrstvfps rvtkerrvrt mprhsqsltm apyssvslve qledrilche kttaalveha
       61 frikddivns lqkmqnkggg drlarlflee hirnitaivk qlnrdievlq eqirardnis
      121 ygtnsalktl emrqlsglgd lrgrvarcda siarlsaehk ttyeglqhln keqqaaklil
      181 etkikdaegq isqllnrvdl siseqstklk mshrdsnhql qlldtkfkgt veelsnqils
      241 arswlqqeqe riekellqki dqlslivken sgaserdmek klsqmsarld kieegqkktf
      301 dgqrtrqeee kmhgritkle lqmnqnikem kaevnagfta vyesigslrq vleakmkldr
      361 dqlqkqiqlm qkpetpm
//
LOCUS       XP_016877421             377 aa            linear   PRI 05-AUG-2025
DEFINITION  protein FAM81A isoform X1 [Homo sapiens].
ACCESSION   XP_016877421
VERSION     XP_016877421.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021932.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..377
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..377
                     /product="protein FAM81A isoform X1"
                     /calculated_mol_wt=43224
     Region          <88..>263
                     /region_name="COG4913"
                     /note="Uncharacterized conserved protein, contains a
                     C-terminal ATPase domain [Function unknown]"
                     /db_xref="CDD:443941"
     Region          166..>372
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..377
                     /gene="FAM81A"
                     /coded_by="XM_017021932.2:297..1430"
                     /db_xref="GeneID:145773"
                     /db_xref="HGNC:HGNC:28379"
ORIGIN      
        1 maqrstvfps rvtkerrvrt mprhsqsltm apyssvslve qledrilche kttaalveha
       61 frikddivns lqkmqnkggg drlarlflee hirnitaivk qlnrdievlq eqirardnis
      121 ygtnsalktl emrqlsglgd lrgrvarcda siarlsaehk ttyeglqhln keqqaaklil
      181 etkikdaegq isqllnrvdl siseqstklk mshrdsnhql qlldtkfkgt veelsnqils
      241 arswlqqeqe riekellqki dqlslivken sgaserdmek klsqmsarld kieegqkktf
      301 dgqrtrqeee kmhgritkle lqmnqnikem kaevnagfta vyesigslrq vleakmkldr
      361 dqlqkqiqlm qkpetpm
//
LOCUS       XP_011519550             377 aa            linear   PRI 05-AUG-2025
DEFINITION  protein FAM81A isoform X1 [Homo sapiens].
ACCESSION   XP_011519550
VERSION     XP_011519550.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521248.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..377
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..377
                     /product="protein FAM81A isoform X1"
                     /calculated_mol_wt=43224
     Region          <88..>263
                     /region_name="COG4913"
                     /note="Uncharacterized conserved protein, contains a
                     C-terminal ATPase domain [Function unknown]"
                     /db_xref="CDD:443941"
     Region          166..>372
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..377
                     /gene="FAM81A"
                     /coded_by="XM_011521248.3:224..1357"
                     /db_xref="GeneID:145773"
                     /db_xref="HGNC:HGNC:28379"
ORIGIN      
        1 maqrstvfps rvtkerrvrt mprhsqsltm apyssvslve qledrilche kttaalveha
       61 frikddivns lqkmqnkggg drlarlflee hirnitaivk qlnrdievlq eqirardnis
      121 ygtnsalktl emrqlsglgd lrgrvarcda siarlsaehk ttyeglqhln keqqaaklil
      181 etkikdaegq isqllnrvdl siseqstklk mshrdsnhql qlldtkfkgt veelsnqils
      241 arswlqqeqe riekellqki dqlslivken sgaserdmek klsqmsarld kieegqkktf
      301 dgqrtrqeee kmhgritkle lqmnqnikem kaevnagfta vyesigslrq vleakmkldr
      361 dqlqkqiqlm qkpetpm
//
LOCUS       XP_006720461             368 aa            linear   PRI 05-AUG-2025
DEFINITION  protein FAM81A isoform X2 [Homo sapiens].
ACCESSION   XP_006720461
VERSION     XP_006720461.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720398.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..368
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..368
                     /product="protein FAM81A isoform X2"
                     /calculated_mol_wt=42261
     Region          <79..>254
                     /region_name="COG4913"
                     /note="Uncharacterized conserved protein, contains a
                     C-terminal ATPase domain [Function unknown]"
                     /db_xref="CDD:443941"
     Region          157..>363
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..368
                     /gene="FAM81A"
                     /coded_by="XM_006720398.4:385..1491"
                     /db_xref="GeneID:145773"
                     /db_xref="HGNC:HGNC:28379"
ORIGIN      
        1 menmhlrrvr tmprhsqslt mapyssvslv eqledrilch ekttaalveh afrikddivn
       61 slqkmqnkgg gdrlarlfle ehirnitaiv kqlnrdievl qeqirardni sygtnsalkt
      121 lemrqlsglg dlrgrvarcd asiarlsaeh kttyeglqhl nkeqqaakli letkikdaeg
      181 qisqllnrvd lsiseqstkl kmshrdsnhq lqlldtkfkg tveelsnqil sarswlqqeq
      241 eriekellqk idqlslivke nsgaserdme kklsqmsarl dkieegqkkt fdgqrtrqee
      301 ekmhgritkl elqmnqnike mkaevnagft avyesigslr qvleakmkld rdqlqkqiql
      361 mqkpetpm
//
LOCUS       XP_047288126             368 aa            linear   PRI 05-AUG-2025
DEFINITION  protein FAM81A isoform X2 [Homo sapiens].
ACCESSION   XP_047288126
VERSION     XP_047288126.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432170.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..368
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..368
                     /product="protein FAM81A isoform X2"
                     /calculated_mol_wt=42261
     Region          <79..>254
                     /region_name="COG4913"
                     /note="Uncharacterized conserved protein, contains a
                     C-terminal ATPase domain [Function unknown]"
                     /db_xref="CDD:443941"
     Region          157..>363
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..368
                     /gene="FAM81A"
                     /coded_by="XM_047432170.1:280..1386"
                     /db_xref="GeneID:145773"
                     /db_xref="HGNC:HGNC:28379"
ORIGIN      
        1 menmhlrrvr tmprhsqslt mapyssvslv eqledrilch ekttaalveh afrikddivn
       61 slqkmqnkgg gdrlarlfle ehirnitaiv kqlnrdievl qeqirardni sygtnsalkt
      121 lemrqlsglg dlrgrvarcd asiarlsaeh kttyeglqhl nkeqqaakli letkikdaeg
      181 qisqllnrvd lsiseqstkl kmshrdsnhq lqlldtkfkg tveelsnqil sarswlqqeq
      241 eriekellqk idqlslivke nsgaserdme kklsqmsarl dkieegqkkt fdgqrtrqee
      301 ekmhgritkl elqmnqnike mkaevnagft avyesigslr qvleakmkld rdqlqkqiql
      361 mqkpetpm
//
LOCUS       XP_011519551             368 aa            linear   PRI 05-AUG-2025
DEFINITION  protein FAM81A isoform X2 [Homo sapiens].
ACCESSION   XP_011519551
VERSION     XP_011519551.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521249.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..368
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..368
                     /product="protein FAM81A isoform X2"
                     /calculated_mol_wt=42261
     Region          <79..>254
                     /region_name="COG4913"
                     /note="Uncharacterized conserved protein, contains a
                     C-terminal ATPase domain [Function unknown]"
                     /db_xref="CDD:443941"
     Region          157..>363
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..368
                     /gene="FAM81A"
                     /coded_by="XM_011521249.3:344..1450"
                     /db_xref="GeneID:145773"
                     /db_xref="HGNC:HGNC:28379"
ORIGIN      
        1 menmhlrrvr tmprhsqslt mapyssvslv eqledrilch ekttaalveh afrikddivn
       61 slqkmqnkgg gdrlarlfle ehirnitaiv kqlnrdievl qeqirardni sygtnsalkt
      121 lemrqlsglg dlrgrvarcd asiarlsaeh kttyeglqhl nkeqqaakli letkikdaeg
      181 qisqllnrvd lsiseqstkl kmshrdsnhq lqlldtkfkg tveelsnqil sarswlqqeq
      241 eriekellqk idqlslivke nsgaserdme kklsqmsarl dkieegqkkt fdgqrtrqee
      301 ekmhgritkl elqmnqnike mkaevnagft avyesigslr qvleakmkld rdqlqkqiql
      361 mqkpetpm
//
LOCUS       XP_011519552             368 aa            linear   PRI 05-AUG-2025
DEFINITION  protein FAM81A isoform X2 [Homo sapiens].
ACCESSION   XP_011519552
VERSION     XP_011519552.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521250.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..368
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..368
                     /product="protein FAM81A isoform X2"
                     /calculated_mol_wt=42261
     Region          <79..>254
                     /region_name="COG4913"
                     /note="Uncharacterized conserved protein, contains a
                     C-terminal ATPase domain [Function unknown]"
                     /db_xref="CDD:443941"
     Region          157..>363
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..368
                     /gene="FAM81A"
                     /coded_by="XM_011521250.3:216..1322"
                     /db_xref="GeneID:145773"
                     /db_xref="HGNC:HGNC:28379"
ORIGIN      
        1 menmhlrrvr tmprhsqslt mapyssvslv eqledrilch ekttaalveh afrikddivn
       61 slqkmqnkgg gdrlarlfle ehirnitaiv kqlnrdievl qeqirardni sygtnsalkt
      121 lemrqlsglg dlrgrvarcd asiarlsaeh kttyeglqhl nkeqqaakli letkikdaeg
      181 qisqllnrvd lsiseqstkl kmshrdsnhq lqlldtkfkg tveelsnqil sarswlqqeq
      241 eriekellqk idqlslivke nsgaserdme kklsqmsarl dkieegqkkt fdgqrtrqee
      301 ekmhgritkl elqmnqnike mkaevnagft avyesigslr qvleakmkld rdqlqkqiql
      361 mqkpetpm
//
LOCUS       XP_047288127             368 aa            linear   PRI 05-AUG-2025
DEFINITION  protein FAM81A isoform X2 [Homo sapiens].
ACCESSION   XP_047288127
VERSION     XP_047288127.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432171.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..368
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..368
                     /product="protein FAM81A isoform X2"
                     /calculated_mol_wt=42261
     Region          <79..>254
                     /region_name="COG4913"
                     /note="Uncharacterized conserved protein, contains a
                     C-terminal ATPase domain [Function unknown]"
                     /db_xref="CDD:443941"
     Region          157..>363
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..368
                     /gene="FAM81A"
                     /coded_by="XM_047432171.1:442..1548"
                     /db_xref="GeneID:145773"
                     /db_xref="HGNC:HGNC:28379"
ORIGIN      
        1 menmhlrrvr tmprhsqslt mapyssvslv eqledrilch ekttaalveh afrikddivn
       61 slqkmqnkgg gdrlarlfle ehirnitaiv kqlnrdievl qeqirardni sygtnsalkt
      121 lemrqlsglg dlrgrvarcd asiarlsaeh kttyeglqhl nkeqqaakli letkikdaeg
      181 qisqllnrvd lsiseqstkl kmshrdsnhq lqlldtkfkg tveelsnqil sarswlqqeq
      241 eriekellqk idqlslivke nsgaserdme kklsqmsarl dkieegqkkt fdgqrtrqee
      301 ekmhgritkl elqmnqnike mkaevnagft avyesigslr qvleakmkld rdqlqkqiql
      361 mqkpetpm
//
LOCUS       XP_024305614             368 aa            linear   PRI 05-AUG-2025
DEFINITION  protein FAM81A isoform X2 [Homo sapiens].
ACCESSION   XP_024305614
VERSION     XP_024305614.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449846.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..368
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..368
                     /product="protein FAM81A isoform X2"
                     /calculated_mol_wt=42261
     Region          <79..>254
                     /region_name="COG4913"
                     /note="Uncharacterized conserved protein, contains a
                     C-terminal ATPase domain [Function unknown]"
                     /db_xref="CDD:443941"
     Region          157..>363
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     CDS             1..368
                     /gene="FAM81A"
                     /coded_by="XM_024449846.2:523..1629"
                     /db_xref="GeneID:145773"
                     /db_xref="HGNC:HGNC:28379"
ORIGIN      
        1 menmhlrrvr tmprhsqslt mapyssvslv eqledrilch ekttaalveh afrikddivn
       61 slqkmqnkgg gdrlarlfle ehirnitaiv kqlnrdievl qeqirardni sygtnsalkt
      121 lemrqlsglg dlrgrvarcd asiarlsaeh kttyeglqhl nkeqqaakli letkikdaeg
      181 qisqllnrvd lsiseqstkl kmshrdsnhq lqlldtkfkg tveelsnqil sarswlqqeq
      241 eriekellqk idqlslivke nsgaserdme kklsqmsarl dkieegqkkt fdgqrtrqee
      301 ekmhgritkl elqmnqnike mkaevnagft avyesigslr qvleakmkld rdqlqkqiql
      361 mqkpetpm
//
LOCUS       XP_011519563             404 aa            linear   PRI 05-AUG-2025
DEFINITION  hyaluronan and proteoglycan link protein 3 isoform X1 [Homo
            sapiens].
ACCESSION   XP_011519563
VERSION     XP_011519563.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521261.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..404
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..404
                     /product="hyaluronan and proteoglycan link protein 3
                     isoform X1"
                     /calculated_mol_wt=45703
     Region          96..212
                     /region_name="Ig_LP_like"
                     /note="Immunoglobulin (Ig)-like domain of human cartilage
                     link protein (LP), and similar domains; cd05877"
                     /db_xref="CDD:409461"
     Region          96..99
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409461"
     Region          102..104
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409461"
     Region          108..116
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409461"
     Region          129..135
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409461"
     Region          142..145
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409461"
     Region          153..156
                     /region_name="putative Ig strand C'"
                     /note="putative Ig strand C' [structural motif]"
                     /db_xref="CDD:409461"
     Region          161..166
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409461"
     Region          172..178
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409461"
     Region          186..193
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409461"
     Region          203..212
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409461"
     Region          210..304
                     /region_name="Link_domain_HAPLN_module_1"
                     /note="this link domain is found in the first link module
                     of proteins similar to the vertebrate HAPLN (hyaluronan/HA
                     and proteoglycan binding link) protein family which
                     includes cartilage link protein. The link domain is a
                     HA-binding domain. HAPLNs contain two...; cd03518"
                     /db_xref="CDD:239595"
     Site            220..221
                     /site_type="other"
                     /note="putative hyaluronan binding site [chemical
                     binding]"
                     /db_xref="CDD:239595"
     Region          311..401
                     /region_name="Link_domain_HAPLN_module_2"
                     /note="this link domain is found in the second link module
                     of proteins similar to the vertebrate HAPLN (hyaluronan/HA
                     and proteoglycan binding link) protein family which
                     includes cartilage link protein. The link domain is a
                     HA-binding domain. HAPLNs contain two...; cd03519"
                     /db_xref="CDD:239596"
     Site            318..319
                     /site_type="other"
                     /note="putative hyaluronan binding site [chemical
                     binding]"
                     /db_xref="CDD:239596"
     CDS             1..404
                     /gene="HAPLN3"
                     /gene_synonym="EXLD1; HsT19883"
                     /coded_by="XM_011521261.2:87..1301"
                     /db_xref="GeneID:145864"
                     /db_xref="HGNC:HGNC:21446"
ORIGIN      
        1 mrkwrhrevn lpevtqqdav cpapipspvc pgapawpgsp wheemgllll vpllllpgsy
       61 glpfyngfyy snsandqnlg nghgkdllng vklvvetpee tlftyqgasv ilpcryryep
      121 alvsprrvrv kwwklsenga pekdvlvaig lrhrsfgdyq grvhlrqdke hdvsleiqdl
      181 rledygryrc evidgledes glvelelrgv vfpyqspngr yqfnfhegqq vcaeqaavva
      241 sfeqlfrawe egldwcnagw lqdatvqypi mlprqpcggp glapgvrsyg prhrrlhryd
      301 vfcfatalkg rvyylehpek ltlteareac qeddatiakv gqlfaawkfh gldrcdagwl
      361 adgsvrypvv hphpncgppe pgvrsfgfpd pqsrlygvyc yrqh
//
LOCUS       XP_047288128             360 aa            linear   PRI 05-AUG-2025
DEFINITION  hyaluronan and proteoglycan link protein 3 isoform X2 [Homo
            sapiens].
ACCESSION   XP_047288128
VERSION     XP_047288128.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432172.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..360
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..360
                     /product="hyaluronan and proteoglycan link protein 3
                     isoform X2"
                     /calculated_mol_wt=40763
     Region          52..168
                     /region_name="Ig_LP_like"
                     /note="Immunoglobulin (Ig)-like domain of human cartilage
                     link protein (LP), and similar domains; cd05877"
                     /db_xref="CDD:409461"
     Region          52..55
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409461"
     Region          58..60
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409461"
     Region          64..72
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409461"
     Region          85..91
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409461"
     Region          98..101
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409461"
     Region          109..112
                     /region_name="putative Ig strand C'"
                     /note="putative Ig strand C' [structural motif]"
                     /db_xref="CDD:409461"
     Region          117..122
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409461"
     Region          128..134
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409461"
     Region          142..149
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409461"
     Region          159..168
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409461"
     Region          166..260
                     /region_name="Link_domain_HAPLN_module_1"
                     /note="this link domain is found in the first link module
                     of proteins similar to the vertebrate HAPLN (hyaluronan/HA
                     and proteoglycan binding link) protein family which
                     includes cartilage link protein. The link domain is a
                     HA-binding domain. HAPLNs contain two...; cd03518"
                     /db_xref="CDD:239595"
     Site            176..177
                     /site_type="other"
                     /note="putative hyaluronan binding site [chemical
                     binding]"
                     /db_xref="CDD:239595"
     Region          267..357
                     /region_name="Link_domain_HAPLN_module_2"
                     /note="this link domain is found in the second link module
                     of proteins similar to the vertebrate HAPLN (hyaluronan/HA
                     and proteoglycan binding link) protein family which
                     includes cartilage link protein. The link domain is a
                     HA-binding domain. HAPLNs contain two...; cd03519"
                     /db_xref="CDD:239596"
     Site            274..275
                     /site_type="other"
                     /note="putative hyaluronan binding site [chemical
                     binding]"
                     /db_xref="CDD:239596"
     CDS             1..360
                     /gene="HAPLN3"
                     /gene_synonym="EXLD1; HsT19883"
                     /coded_by="XM_047432172.1:2003..3085"
                     /db_xref="GeneID:145864"
                     /db_xref="HGNC:HGNC:21446"
ORIGIN      
        1 mgllllvpll llpgsyglpf yngfyysnsa ndqnlgnghg kdllngvklv vetpeetlft
       61 yqgasvilpc ryryepalvs prrvrvkwwk lsengapekd vlvaiglrhr sfgdyqgrvh
      121 lrqdkehdvs leiqdlrled ygryrcevid gledesglve lelrgvvfpy qspngryqfn
      181 fhegqqvcae qaavvasfeq lfraweegld wcnagwlqda tvqypimlpr qpcggpglap
      241 gvrsygprhr rlhrydvfcf atalkgrvyy lehpekltlt eareacqedd atiakvgqlf
      301 aawkfhgldr cdagwladgs vrypvvhphp ncgppepgvr sfgfpdpqsr lygvycyrqh
//
LOCUS       XP_016877423             321 aa            linear   PRI 05-AUG-2025
DEFINITION  hyaluronan and proteoglycan link protein 3 isoform X3 [Homo
            sapiens].
ACCESSION   XP_016877423
VERSION     XP_016877423.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021934.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..321
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..321
                     /product="hyaluronan and proteoglycan link protein 3
                     isoform X3"
                     /calculated_mol_wt=36182
     Region          114..230
                     /region_name="Ig_LP_like"
                     /note="Immunoglobulin (Ig)-like domain of human cartilage
                     link protein (LP), and similar domains; cd05877"
                     /db_xref="CDD:409461"
     Region          114..117
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409461"
     Region          120..122
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409461"
     Region          126..134
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409461"
     Region          147..153
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409461"
     Region          160..163
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409461"
     Region          171..174
                     /region_name="putative Ig strand C'"
                     /note="putative Ig strand C' [structural motif]"
                     /db_xref="CDD:409461"
     Region          179..184
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409461"
     Region          190..196
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409461"
     Region          204..211
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409461"
     Region          221..230
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409461"
     Region          228..318
                     /region_name="Link_domain_HAPLN_module_2"
                     /note="this link domain is found in the second link module
                     of proteins similar to the vertebrate HAPLN (hyaluronan/HA
                     and proteoglycan binding link) protein family which
                     includes cartilage link protein. The link domain is a
                     HA-binding domain. HAPLNs contain two...; cd03519"
                     /db_xref="CDD:239596"
     Site            235..236
                     /site_type="other"
                     /note="putative hyaluronan binding site [chemical
                     binding]"
                     /db_xref="CDD:239596"
     CDS             1..321
                     /gene="HAPLN3"
                     /gene_synonym="EXLD1; HsT19883"
                     /coded_by="XM_017021934.3:87..1052"
                     /db_xref="GeneID:145864"
                     /db_xref="HGNC:HGNC:21446"
ORIGIN      
        1 mrkwrhrevn lpevtqqdav cpapipspgl saqtglqkiw gtihcqvcpg apawpgspwh
       61 eemgllllvp llllpgsygl pfyngfyysn sandqnlgng hgkdllngvk lvvetpeetl
      121 ftyqgasvil pcryryepal vsprrvrvkw wklsengape kdvlvaiglr hrsfgdyqgr
      181 vhlrqdkehd vsleiqdlrl edygryrcev idgledesgl velelrgrvy ylehpekltl
      241 teareacqed datiakvgql faawkfhgld rcdagwladg svrypvvhph pncgppepgv
      301 rsfgfpdpqs rlygvycyrq h
//
LOCUS       XP_047288129             253 aa            linear   PRI 05-AUG-2025
DEFINITION  hyaluronan and proteoglycan link protein 3 isoform X4 [Homo
            sapiens].
ACCESSION   XP_047288129
VERSION     XP_047288129.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432173.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..253
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..253
                     /product="hyaluronan and proteoglycan link protein 3
                     isoform X4"
                     /calculated_mol_wt=28670
     Region          59..153
                     /region_name="Link_Domain"
                     /note="The link domain is a hyaluronan (HA)-binding
                     domain. It functions to mediate adhesive interactions
                     during inflammatory leukocyte homing and tumor metastasis.
                     It is found in the CD44 receptor and in human TSG-6. TSG-6
                     is the protein product of the tumor...; cl02612"
                     /db_xref="CDD:470631"
     Site            69..70
                     /site_type="other"
                     /note="putative hyaluronan binding site [chemical
                     binding]"
                     /db_xref="CDD:239595"
     Region          160..250
                     /region_name="Link_domain_HAPLN_module_2"
                     /note="this link domain is found in the second link module
                     of proteins similar to the vertebrate HAPLN (hyaluronan/HA
                     and proteoglycan binding link) protein family which
                     includes cartilage link protein. The link domain is a
                     HA-binding domain. HAPLNs contain two...; cd03519"
                     /db_xref="CDD:239596"
     Site            167..168
                     /site_type="other"
                     /note="putative hyaluronan binding site [chemical
                     binding]"
                     /db_xref="CDD:239596"
     CDS             1..253
                     /gene="HAPLN3"
                     /gene_synonym="EXLD1; HsT19883"
                     /coded_by="XM_047432173.1:99..860"
                     /db_xref="GeneID:145864"
                     /db_xref="HGNC:HGNC:21446"
ORIGIN      
        1 mtsrwrsric gwrtmgvtav rsltgwrmka vwwswscgyc cepaesqerg gngqevrgvv
       61 fpyqspngry qfnfhegqqv caeqaavvas feqlfrawee gldwcnagwl qdatvqypim
      121 lprqpcggpg lapgvrsygp rhrrlhrydv fcfatalkgr vyylehpekl tlteareacq
      181 eddatiakvg qlfaawkfhg ldrcdagwla dgsvrypvvh phpncgppep gvrsfgfpdp
      241 qsrlygvycy rqh
//
LOCUS       XP_047288130             248 aa            linear   PRI 05-AUG-2025
DEFINITION  hyaluronan and proteoglycan link protein 3 isoform X5 [Homo
            sapiens].
ACCESSION   XP_047288130
VERSION     XP_047288130.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432174.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..248
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..248
                     /product="hyaluronan and proteoglycan link protein 3
                     isoform X5"
                     /calculated_mol_wt=27880
     Region          114..227
                     /region_name="Ig_LP_like"
                     /note="Immunoglobulin (Ig)-like domain of human cartilage
                     link protein (LP), and similar domains; cd05877"
                     /db_xref="CDD:409461"
     Region          114..117
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409461"
     Region          120..122
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409461"
     Region          126..134
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409461"
     Region          147..153
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409461"
     Region          160..163
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409461"
     Region          171..174
                     /region_name="putative Ig strand C'"
                     /note="putative Ig strand C' [structural motif]"
                     /db_xref="CDD:409461"
     Region          179..184
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409461"
     Region          190..196
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409461"
     Region          204..211
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409461"
     CDS             1..248
                     /gene="HAPLN3"
                     /gene_synonym="EXLD1; HsT19883"
                     /coded_by="XM_047432174.1:87..833"
                     /db_xref="GeneID:145864"
                     /db_xref="HGNC:HGNC:21446"
ORIGIN      
        1 mrkwrhrevn lpevtqqdav cpapipspgl saqtglqkiw gtihcqvcpg apawpgspwh
       61 eemgllllvp llllpgsygl pfyngfyysn sandqnlgng hgkdllngvk lvvetpeetl
      121 ftyqgasvil pcryryepal vsprrvrvkw wklsengape kdvlvaiglr hrsfgdyqgr
      181 vhlrqdkehd vsleiqdlrl edygryrcev idgledesgl velelrgwgc vsshlshmlg
      241 rqfgdrgr
//
LOCUS       XP_047288131             229 aa            linear   PRI 05-AUG-2025
DEFINITION  hyaluronan and proteoglycan link protein 3 isoform X6 [Homo
            sapiens].
ACCESSION   XP_047288131
VERSION     XP_047288131.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432175.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..229
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..229
                     /product="hyaluronan and proteoglycan link protein 3
                     isoform X6"
                     /calculated_mol_wt=25780
     Region          114..219
                     /region_name="Ig_LP_like"
                     /note="Immunoglobulin (Ig)-like domain of human cartilage
                     link protein (LP), and similar domains; cd05877"
                     /db_xref="CDD:409461"
     Region          114..117
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409461"
     Region          120..122
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409461"
     Region          126..134
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409461"
     Region          147..153
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409461"
     Region          160..163
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409461"
     Region          171..174
                     /region_name="putative Ig strand C'"
                     /note="putative Ig strand C' [structural motif]"
                     /db_xref="CDD:409461"
     Region          179..184
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409461"
     Region          190..196
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409461"
     Region          204..211
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409461"
     CDS             1..229
                     /gene="HAPLN3"
                     /gene_synonym="EXLD1; HsT19883"
                     /coded_by="XM_047432175.1:87..776"
                     /db_xref="GeneID:145864"
                     /db_xref="HGNC:HGNC:21446"
ORIGIN      
        1 mrkwrhrevn lpevtqqdav cpapipspgl saqtglqkiw gtihcqvcpg apawpgspwh
       61 eemgllllvp llllpgsygl pfyngfyysn sandqnlgng hgkdllngvk lvvetpeetl
      121 ftyqgasvil pcryryepal vsprrvrvkw wklsengape kdvlvaiglr hrsfgdyqgr
      181 vhlrqdkehd vsleiqdlrl edygryrcev idgledesgl velelrvll
//
LOCUS       XP_047288132             239 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane and coiled-coil domain-containing protein 5A isoform
            X1 [Homo sapiens].
ACCESSION   XP_047288132
VERSION     XP_047288132.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432176.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..239
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..239
                     /product="transmembrane and coiled-coil domain-containing
                     protein 5A isoform X1"
                     /calculated_mol_wt=27904
     Region          13..>225
                     /region_name="TMCO5"
                     /note="TMCO5 family; pfam14992"
                     /db_xref="CDD:464427"
     CDS             1..239
                     /gene="TMCO5A"
                     /gene_synonym="TMCO5"
                     /coded_by="XM_047432176.1:158..877"
                     /db_xref="GeneID:145942"
                     /db_xref="HGNC:HGNC:28558"
ORIGIN      
        1 meisrlaqsk rniislnmdl erdtqridea nqklllkiqe redkiqrles eiiqtrglve
       61 deewekenrt tmereralqe leeetarler knktlvhsit elqqkltrks qkitnceqss
      121 pdgaleetkv klqqleasya cqekellkvm keyafvtqlc edqalyikky qetlkkieee
      181 lealflerev sklvsmnpve kehtsqnneg tptqktarlf skklsardep evsassqvf
//
LOCUS       XP_047288133             239 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane and coiled-coil domain-containing protein 5A isoform
            X1 [Homo sapiens].
ACCESSION   XP_047288133
VERSION     XP_047288133.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432177.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..239
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..239
                     /product="transmembrane and coiled-coil domain-containing
                     protein 5A isoform X1"
                     /calculated_mol_wt=27904
     Region          13..>225
                     /region_name="TMCO5"
                     /note="TMCO5 family; pfam14992"
                     /db_xref="CDD:464427"
     CDS             1..239
                     /gene="TMCO5A"
                     /gene_synonym="TMCO5"
                     /coded_by="XM_047432177.1:158..877"
                     /db_xref="GeneID:145942"
                     /db_xref="HGNC:HGNC:28558"
ORIGIN      
        1 meisrlaqsk rniislnmdl erdtqridea nqklllkiqe redkiqrles eiiqtrglve
       61 deewekenrt tmereralqe leeetarler knktlvhsit elqqkltrks qkitnceqss
      121 pdgaleetkv klqqleasya cqekellkvm keyafvtqlc edqalyikky qetlkkieee
      181 lealflerev sklvsmnpve kehtsqnneg tptqktarlf skklsardep evsassqvf
//
LOCUS       XP_011519564             239 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane and coiled-coil domain-containing protein 5A isoform
            X1 [Homo sapiens].
ACCESSION   XP_011519564
VERSION     XP_011519564.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521262.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..239
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..239
                     /product="transmembrane and coiled-coil domain-containing
                     protein 5A isoform X1"
                     /calculated_mol_wt=27904
     Region          13..>225
                     /region_name="TMCO5"
                     /note="TMCO5 family; pfam14992"
                     /db_xref="CDD:464427"
     CDS             1..239
                     /gene="TMCO5A"
                     /gene_synonym="TMCO5"
                     /coded_by="XM_011521262.3:158..877"
                     /db_xref="GeneID:145942"
                     /db_xref="HGNC:HGNC:28558"
ORIGIN      
        1 meisrlaqsk rniislnmdl erdtqridea nqklllkiqe redkiqrles eiiqtrglve
       61 deewekenrt tmereralqe leeetarler knktlvhsit elqqkltrks qkitnceqss
      121 pdgaleetkv klqqleasya cqekellkvm keyafvtqlc edqalyikky qetlkkieee
      181 lealflerev sklvsmnpve kehtsqnneg tptqktarlf skklsardep evsassqvf
//
LOCUS       XP_047288134             123 aa            linear   PRI 05-AUG-2025
DEFINITION  pro-neuregulin-4, membrane-bound isoform isoform X1 [Homo sapiens].
ACCESSION   XP_047288134
VERSION     XP_047288134.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432178.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..123
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..123
                     /product="pro-neuregulin-4, membrane-bound isoform isoform
                     X1"
                     /calculated_mol_wt=13541
     Region          <9..83
                     /region_name="PHA03099"
                     /note="epidermal growth factor-like protein (EGF-like
                     protein); Provisional"
                     /db_xref="CDD:165381"
     CDS             1..123
                     /gene="NRG4"
                     /gene_synonym="HRG4"
                     /coded_by="XM_047432178.1:163..534"
                     /db_xref="GeneID:145957"
                     /db_xref="HGNC:HGNC:29862"
                     /db_xref="MIM:610894"
ORIGIN      
        1 mptdheepcg pshksfclng glcyviptip spfcrcveny tgarceevfl pgssiqtksn
       61 lfeafvalav lvtliigafy flcrkghfqr assvqydinl vetsstsahh rfslsqlips
      121 fyk
//
LOCUS       XP_047288135             123 aa            linear   PRI 05-AUG-2025
DEFINITION  pro-neuregulin-4, membrane-bound isoform isoform X1 [Homo sapiens].
ACCESSION   XP_047288135
VERSION     XP_047288135.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432179.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..123
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..123
                     /product="pro-neuregulin-4, membrane-bound isoform isoform
                     X1"
                     /calculated_mol_wt=13541
     Region          <9..83
                     /region_name="PHA03099"
                     /note="epidermal growth factor-like protein (EGF-like
                     protein); Provisional"
                     /db_xref="CDD:165381"
     CDS             1..123
                     /gene="NRG4"
                     /gene_synonym="HRG4"
                     /coded_by="XM_047432179.1:180..551"
                     /db_xref="GeneID:145957"
                     /db_xref="HGNC:HGNC:29862"
                     /db_xref="MIM:610894"
ORIGIN      
        1 mptdheepcg pshksfclng glcyviptip spfcrcveny tgarceevfl pgssiqtksn
       61 lfeafvalav lvtliigafy flcrkghfqr assvqydinl vetsstsahh rfslsqlips
      121 fyk
//
LOCUS       XP_047288136             123 aa            linear   PRI 05-AUG-2025
DEFINITION  pro-neuregulin-4, membrane-bound isoform isoform X1 [Homo sapiens].
ACCESSION   XP_047288136
VERSION     XP_047288136.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432180.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..123
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..123
                     /product="pro-neuregulin-4, membrane-bound isoform isoform
                     X1"
                     /calculated_mol_wt=13541
     Region          <9..83
                     /region_name="PHA03099"
                     /note="epidermal growth factor-like protein (EGF-like
                     protein); Provisional"
                     /db_xref="CDD:165381"
     CDS             1..123
                     /gene="NRG4"
                     /gene_synonym="HRG4"
                     /coded_by="XM_047432180.1:463..834"
                     /db_xref="GeneID:145957"
                     /db_xref="HGNC:HGNC:29862"
                     /db_xref="MIM:610894"
ORIGIN      
        1 mptdheepcg pshksfclng glcyviptip spfcrcveny tgarceevfl pgssiqtksn
       61 lfeafvalav lvtliigafy flcrkghfqr assvqydinl vetsstsahh rfslsqlips
      121 fyk
//
LOCUS       XP_047288137             123 aa            linear   PRI 05-AUG-2025
DEFINITION  pro-neuregulin-4, membrane-bound isoform isoform X1 [Homo sapiens].
ACCESSION   XP_047288137
VERSION     XP_047288137.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432181.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..123
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..123
                     /product="pro-neuregulin-4, membrane-bound isoform isoform
                     X1"
                     /calculated_mol_wt=13541
     Region          <9..83
                     /region_name="PHA03099"
                     /note="epidermal growth factor-like protein (EGF-like
                     protein); Provisional"
                     /db_xref="CDD:165381"
     CDS             1..123
                     /gene="NRG4"
                     /gene_synonym="HRG4"
                     /coded_by="XM_047432181.1:461..832"
                     /db_xref="GeneID:145957"
                     /db_xref="HGNC:HGNC:29862"
                     /db_xref="MIM:610894"
ORIGIN      
        1 mptdheepcg pshksfclng glcyviptip spfcrcveny tgarceevfl pgssiqtksn
       61 lfeafvalav lvtliigafy flcrkghfqr assvqydinl vetsstsahh rfslsqlips
      121 fyk
//
LOCUS       XP_047288138             123 aa            linear   PRI 05-AUG-2025
DEFINITION  pro-neuregulin-4, membrane-bound isoform isoform X1 [Homo sapiens].
ACCESSION   XP_047288138
VERSION     XP_047288138.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432182.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..123
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..123
                     /product="pro-neuregulin-4, membrane-bound isoform isoform
                     X1"
                     /calculated_mol_wt=13541
     Region          <9..83
                     /region_name="PHA03099"
                     /note="epidermal growth factor-like protein (EGF-like
                     protein); Provisional"
                     /db_xref="CDD:165381"
     CDS             1..123
                     /gene="NRG4"
                     /gene_synonym="HRG4"
                     /coded_by="XM_047432182.1:330..701"
                     /db_xref="GeneID:145957"
                     /db_xref="HGNC:HGNC:29862"
                     /db_xref="MIM:610894"
ORIGIN      
        1 mptdheepcg pshksfclng glcyviptip spfcrcveny tgarceevfl pgssiqtksn
       61 lfeafvalav lvtliigafy flcrkghfqr assvqydinl vetsstsahh rfslsqlips
      121 fyk
//
LOCUS       XP_047288139             123 aa            linear   PRI 05-AUG-2025
DEFINITION  pro-neuregulin-4, membrane-bound isoform isoform X1 [Homo sapiens].
ACCESSION   XP_047288139
VERSION     XP_047288139.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432183.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..123
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..123
                     /product="pro-neuregulin-4, membrane-bound isoform isoform
                     X1"
                     /calculated_mol_wt=13541
     Region          <9..83
                     /region_name="PHA03099"
                     /note="epidermal growth factor-like protein (EGF-like
                     protein); Provisional"
                     /db_xref="CDD:165381"
     CDS             1..123
                     /gene="NRG4"
                     /gene_synonym="HRG4"
                     /coded_by="XM_047432183.1:462..833"
                     /db_xref="GeneID:145957"
                     /db_xref="HGNC:HGNC:29862"
                     /db_xref="MIM:610894"
ORIGIN      
        1 mptdheepcg pshksfclng glcyviptip spfcrcveny tgarceevfl pgssiqtksn
       61 lfeafvalav lvtliigafy flcrkghfqr assvqydinl vetsstsahh rfslsqlips
      121 fyk
//
LOCUS       XP_047288140             123 aa            linear   PRI 05-AUG-2025
DEFINITION  pro-neuregulin-4, membrane-bound isoform isoform X1 [Homo sapiens].
ACCESSION   XP_047288140
VERSION     XP_047288140.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432184.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..123
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..123
                     /product="pro-neuregulin-4, membrane-bound isoform isoform
                     X1"
                     /calculated_mol_wt=13541
     Region          <9..83
                     /region_name="PHA03099"
                     /note="epidermal growth factor-like protein (EGF-like
                     protein); Provisional"
                     /db_xref="CDD:165381"
     CDS             1..123
                     /gene="NRG4"
                     /gene_synonym="HRG4"
                     /coded_by="XM_047432184.1:668..1039"
                     /db_xref="GeneID:145957"
                     /db_xref="HGNC:HGNC:29862"
                     /db_xref="MIM:610894"
ORIGIN      
        1 mptdheepcg pshksfclng glcyviptip spfcrcveny tgarceevfl pgssiqtksn
       61 lfeafvalav lvtliigafy flcrkghfqr assvqydinl vetsstsahh rfslsqlips
      121 fyk
//
LOCUS       XP_047288141             115 aa            linear   PRI 05-AUG-2025
DEFINITION  pro-neuregulin-4, membrane-bound isoform isoform X2 [Homo sapiens].
ACCESSION   XP_047288141
VERSION     XP_047288141.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432185.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..115
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..115
                     /product="pro-neuregulin-4, membrane-bound isoform isoform
                     X2"
                     /calculated_mol_wt=12591
     Region          <9..83
                     /region_name="PHA03099"
                     /note="epidermal growth factor-like protein (EGF-like
                     protein); Provisional"
                     /db_xref="CDD:165381"
     CDS             1..115
                     /gene="NRG4"
                     /gene_synonym="HRG4"
                     /coded_by="XM_047432185.1:180..527"
                     /db_xref="GeneID:145957"
                     /db_xref="HGNC:HGNC:29862"
                     /db_xref="MIM:610894"
ORIGIN      
        1 mptdheepcg pshksfclng glcyviptip spfcrcveny tgarceevfl pgssiqtksn
       61 lfeafvalav lvtliigafy flcrkghfqr assvqydinl vetsstsahh sheqh
//
LOCUS       XP_047288142             115 aa            linear   PRI 05-AUG-2025
DEFINITION  pro-neuregulin-4, membrane-bound isoform isoform X2 [Homo sapiens].
ACCESSION   XP_047288142
VERSION     XP_047288142.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432186.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..115
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..115
                     /product="pro-neuregulin-4, membrane-bound isoform isoform
                     X2"
                     /calculated_mol_wt=12591
     Region          <9..83
                     /region_name="PHA03099"
                     /note="epidermal growth factor-like protein (EGF-like
                     protein); Provisional"
                     /db_xref="CDD:165381"
     CDS             1..115
                     /gene="NRG4"
                     /gene_synonym="HRG4"
                     /coded_by="XM_047432186.1:463..810"
                     /db_xref="GeneID:145957"
                     /db_xref="HGNC:HGNC:29862"
                     /db_xref="MIM:610894"
ORIGIN      
        1 mptdheepcg pshksfclng glcyviptip spfcrcveny tgarceevfl pgssiqtksn
       61 lfeafvalav lvtliigafy flcrkghfqr assvqydinl vetsstsahh sheqh
//
LOCUS       XP_024305616             115 aa            linear   PRI 05-AUG-2025
DEFINITION  pro-neuregulin-4, membrane-bound isoform isoform X2 [Homo sapiens].
ACCESSION   XP_024305616
VERSION     XP_024305616.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449848.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..115
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..115
                     /product="pro-neuregulin-4, membrane-bound isoform isoform
                     X2"
                     /calculated_mol_wt=12591
     Region          <9..83
                     /region_name="PHA03099"
                     /note="epidermal growth factor-like protein (EGF-like
                     protein); Provisional"
                     /db_xref="CDD:165381"
     CDS             1..115
                     /gene="NRG4"
                     /gene_synonym="HRG4"
                     /coded_by="XM_024449848.2:236..583"
                     /db_xref="GeneID:145957"
                     /db_xref="HGNC:HGNC:29862"
                     /db_xref="MIM:610894"
ORIGIN      
        1 mptdheepcg pshksfclng glcyviptip spfcrcveny tgarceevfl pgssiqtksn
       61 lfeafvalav lvtliigafy flcrkghfqr assvqydinl vetsstsahh sheqh
//
LOCUS       XP_016877437             115 aa            linear   PRI 05-AUG-2025
DEFINITION  pro-neuregulin-4, membrane-bound isoform isoform X2 [Homo sapiens].
ACCESSION   XP_016877437
VERSION     XP_016877437.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021948.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..115
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..115
                     /product="pro-neuregulin-4, membrane-bound isoform isoform
                     X2"
                     /calculated_mol_wt=12591
     Region          <9..83
                     /region_name="PHA03099"
                     /note="epidermal growth factor-like protein (EGF-like
                     protein); Provisional"
                     /db_xref="CDD:165381"
     CDS             1..115
                     /gene="NRG4"
                     /gene_synonym="HRG4"
                     /coded_by="XM_017021948.3:254..601"
                     /db_xref="GeneID:145957"
                     /db_xref="HGNC:HGNC:29862"
                     /db_xref="MIM:610894"
ORIGIN      
        1 mptdheepcg pshksfclng glcyviptip spfcrcveny tgarceevfl pgssiqtksn
       61 lfeafvalav lvtliigafy flcrkghfqr assvqydinl vetsstsahh sheqh
//
LOCUS       XP_047288143             852 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger and SCAN domain-containing protein 29 isoform X1 [Homo
            sapiens].
ACCESSION   XP_047288143
VERSION     XP_047288143.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432187.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..852
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..852
                     /product="zinc finger and SCAN domain-containing protein
                     29 isoform X1"
                     /calculated_mol_wt=96588
     Region          14..124
                     /region_name="SCAN"
                     /note="leucine rich region; smart00431"
                     /db_xref="CDD:128708"
     Region          245..326
                     /region_name="Myb_DNA-bind_4"
                     /note="Myb/SANT-like DNA-binding domain; pfam13837"
                     /db_xref="CDD:463994"
     Region          408..489
                     /region_name="Myb_DNA-bind_4"
                     /note="Myb/SANT-like DNA-binding domain; pfam13837"
                     /db_xref="CDD:463994"
     Region          <630..838
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          680..700
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(685,687,689,691..692,695..696,699,713,715,719..720,
                     723..724,727,741,743,745,747..748,751..752,755)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          708..728
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          736..756
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          764..784
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          792..812
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          820..840
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..852
                     /gene="ZSCAN29"
                     /gene_synonym="Zfp690; ZNF690"
                     /coded_by="XM_047432187.1:919..3477"
                     /db_xref="GeneID:146050"
                     /db_xref="HGNC:HGNC:26673"
                     /db_xref="MIM:620932"
ORIGIN      
        1 mmaksalren gtnsetfrqr frrfhyqeva gpreafsqlw elccrwlrpe vrtkeqivel
       61 lvleqfltvl pgeiqnwvqe qcpengeeav tlvedlerep grprssvtvs vkgqevrlek
      121 mtppkssqel lsvrqesvep qprgvpkker arspdlgpqe qmnpkeklkp fqrsglpfpk
      181 sgvvsrleqg epwipdllgs kekelpsgsh igdrrvhadl lpskkdrrsw veqdhwsfed
      241 ekvagvhwgy eetrtllail sqtefyealr nchrnsqvyg avaerlreyg flrtleqcrt
      301 kfkglqksyr kvksghppet cpffeemeal msaqvialps ngleaaashs glvgsdaete
      361 epgqrgwqhe egaeeavaqe sdsddmdlea tpqdpnsaap vvfrspggvh wgyeetktyl
      421 ailsetqfye alrnchrnsq lygavaerlw eygflrtpeq crtkfkslqt syrkvkngqa
      481 petcpffeem dalvsvrvaa ppndgqeeta scpvqgtsea eaqkqaeead eateedsddd
      541 eedteippga vitrapvlfq sprgfeagfe nednskrdis eevqlhrtll arserkipry
      601 lhqgkgnesd crsgrqwakt sgekrgkltl pekslsevls qqrpclgerp ykylkysksf
      661 gpnsllmhqv shqvenpykc adcgksfsrs arlirhrrih tgekpykcld cgksfrdssn
      721 fithrrihtg ekpyqcgecg kcfnqsssli ihqrthtgek pyqceecgks fnnsshfsah
      781 rrihtgerph vcpdcgksfs kssdlrahhr thtgekpygc hdcgkcfsks salnkhgeih
      841 areklltqsa pk
//
LOCUS       XP_047288144             526 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger and SCAN domain-containing protein 29 isoform X2 [Homo
            sapiens].
ACCESSION   XP_047288144
VERSION     XP_047288144.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432188.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 23% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..526
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..526
                     /product="zinc finger and SCAN domain-containing protein
                     29 isoform X2"
                     /calculated_mol_wt=58740
     Region          82..163
                     /region_name="Myb_DNA-bind_4"
                     /note="Myb/SANT-like DNA-binding domain; pfam13837"
                     /db_xref="CDD:463994"
     Region          <304..512
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          354..374
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(359,361,363,365..366,369..370,373,387,389,393..394,
                     397..398,401,415,417,419,421..422,425..426,429)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          382..402
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          410..430
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          438..458
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          466..486
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          494..514
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..526
                     /gene="ZSCAN29"
                     /gene_synonym="Zfp690; ZNF690"
                     /coded_by="XM_047432188.1:923..2503"
                     /db_xref="GeneID:146050"
                     /db_xref="HGNC:HGNC:26673"
                     /db_xref="MIM:620932"
ORIGIN      
        1 mealmsaqvi alpsngleaa ashsglvgsd aeteepgqrg wqheegaeea vaqesdsddm
       61 dleatpqdpn saapvvfrsp ggvhwgyeet ktylailset qfyealrnch rnsqlygava
      121 erlweygflr tpeqcrtkfk slqtsyrkvk ngqapetcpf feemdalvsv rvaappndgq
      181 eetascpvqg tseaeaqkqa eeadeateed sdddeedtei ppgavitrap vlfqsprgfe
      241 agfenednsk rdiseevqlh rtllarserk iprylhqgkg nesdcrsgrq waktsgekrg
      301 kltlpeksls evlsqqrpcl gerpykylky sksfgpnsll mhqvshqven pykcadcgks
      361 fsrsarlirh rrihtgekpy kcldcgksfr dssnfithrr ihtgekpyqc gecgkcfnqs
      421 ssliihqrth tgekpyqcee cgksfnnssh fsahrrihtg erphvcpdcg ksfskssdlr
      481 ahhrthtgek pygchdcgkc fskssalnkh geiharekll tqsapk
//
LOCUS       XP_005254228            1250 aa            linear   PRI 05-AUG-2025
DEFINITION  tau-tubulin kinase 2 isoform X1 [Homo sapiens].
ACCESSION   XP_005254228
VERSION     XP_005254228.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254171.6
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1250
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1250
                     /product="tau-tubulin kinase 2 isoform X1"
                     /calculated_mol_wt=138118
     Region          75..287
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..1250
                     /gene="TTBK2"
                     /gene_synonym="SCA11; TTBK"
                     /coded_by="XM_005254171.6:922..4674"
                     /db_xref="GeneID:146057"
                     /db_xref="HGNC:HGNC:19141"
                     /db_xref="MIM:611695"
ORIGIN      
        1 mfcqigevnn plgcqdtlfy sevnfvsvea tvevkwkppl gtgclcscst isvycnewgr
       61 raagypecwn pserkmesgk dhvcrfigcg rndrfnyvvm qlqgrnladl rrsqsrgtft
      121 isttlrlgrq ilesiesihs vgflhrdikp snfamgrfps tcrkcymldf glarqftnsc
      181 gdvrpprava gfrgtvryas inahrnremg rhddlwslfy mlvefvvgql pwrkikdkeq
      241 vgsikerydh rlmlkhlppe fsifldhiss ldyftkpdyq lltsvfdnsi ktfgviesdp
      301 fdwektgndg sltttttstt pqlhtrltpa aigianatpi pgdllrentd evfpdeqlsd
      361 gengipvgvs pdklpgslgh prpqekdvwe emdanknkik lgickaatee enshgqangl
      421 lnapslgspi rvrseitqpd rdiplvrklr sihsfelekr ltlepkpdtd kfletclekm
      481 qkdtsagkes ilpallhkpc vpavsrtdhi whydeeylpd askpasantp eqadgggsng
      541 fiavnlssck qeidskewvi vdkeqdlqdf rtneavghkt tgspsdeepe vlqvleaspq
      601 deklqlgpwa endhlkkets gvvlalsaeg pptaaseqyt drlelqpgaa sqfiaatpts
      661 lmeaqaegpl taitiprpsv astqstsgsf hcgqqpekkd lqpmeptvel ysprenfsgl
      721 vvtegeppsg gsrtdlglqi dhighdmlpn iresnksqdl gpkelpdhnr lvvrefenlp
      781 geteeksill esdnedekls rgqhcieiss lpgdlvivek dhsattepld vtktqtfsvv
      841 pnqdknneim klltvgtsei ssrdidphve gqigqvaemq knkiskdddi msedlpghqg
      901 dlstflhqeg krekitprng elfhcvsene hgaptrkdmv rssfvtrhsr ipvlaqeids
      961 tlessspvsa kekllqkkay qpdlvkllve krqfksflgd lssasdklle eklatvpapf
     1021 ceeevltpfs rltvdshlsr saedsflspi isqsrkskip rpvswvntdq vnsstssqff
     1081 prpppgkppt rpgvearlrr ykvlgssnsd sdlfsrlaqi lqngsqkprs ttqckspgsp
     1141 hnpktppksp vvprrspsas prssslprts ssspsragrp hhdqrsssph lgrsksppsh
     1201 sgssssrrsc qqehckpskn glkgsgslhh hsastktpqg kskpasklsr
//
LOCUS       XP_047288145            1244 aa            linear   PRI 05-AUG-2025
DEFINITION  tau-tubulin kinase 2 isoform X2 [Homo sapiens].
ACCESSION   XP_047288145
VERSION     XP_047288145.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432189.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1244
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1244
                     /product="tau-tubulin kinase 2 isoform X2"
                     /calculated_mol_wt=137282
     Region          20..281
                     /region_name="STKc_TTBK2"
                     /note="Catalytic domain of the Serine/Threonine protein
                     kinase, Tau-Tubulin Kinase 2; cd14129"
                     /db_xref="CDD:271031"
     Site            order(27..31,35,48,50,78,94..97,100,102,141,143,145..146,
                     148,163,166,188..191)
                     /site_type="active"
                     /db_xref="CDD:271031"
     Site            order(27..31,35,48,50,78,94..97,100,141,143,145..146,148,
                     163)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271031"
     Site            order(31,100,102,141,143,145,166,188..191)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:271031"
     Site            order(162..168,188..191)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:271031"
     CDS             1..1244
                     /gene="TTBK2"
                     /gene_synonym="SCA11; TTBK"
                     /coded_by="XM_047432189.1:227..3961"
                     /db_xref="GeneID:146057"
                     /db_xref="HGNC:HGNC:19141"
                     /db_xref="MIM:611695"
ORIGIN      
        1 msgggeqldi lsvgilvker wkvlrkiggg gfgeiydald mltrenvalk vesaqqpkqv
       61 lkmevavlkk lqgkdhvcrf igcgrndrfn yvvmqlqgrn ladlrrsqsr gtftisttlr
      121 lgrqilesie sihsvgflhr dikpsnfamg rfpstcrkcy mldfglarqf tnscgdvrpp
      181 ravagfrgtv ryasinahrn remgrhddlw slfymlvefv vgqlpwrkik dkeqvgsike
      241 rydhrlmlkh lppefsifld hissldyftk pdyqlltsvf dnsiktfgvi esdpfdwekt
      301 gndgsltttt tsttpqlhtr ltpaaigian atpipgdllr entdevfpde qlsdgengip
      361 vgvspdklpg slghprpqek dvweemdank nkiklgicka ateeenshgq angllnapsl
      421 gspirvrsei tqpdrdiplv rklrsihsfe lekrltlepk pdtdkfletc lekmqkdtsa
      481 gkesilpall hkpcvpavsr tdhiwhydee ylpdaskpas antpeqadgg gsngfiavnl
      541 ssckqeidsk ewvivdkeqd lqdfrtneav ghkttgspsd eepevlqvle aspqdeklql
      601 gpwaendhlk ketsgvvlal saegpptaas eqytdrlelq pgaasqfiaa tptslmeaqa
      661 egpltaitip rpsvastqst sgsfhcgqqp ekkdlqpmep tvelyspren fsglvvtege
      721 ppsggsrtdl glqidhighd mlpniresnk sqdlgpkelp dhnrlvvref enlpgeteek
      781 sillesdned eklsrgqhci eisslpgdlv ivekdhsatt epldvtktqt fsvvpnqdkn
      841 neimklltvg tseissrdid phvegqigqv aemqknkisk dddimsedlp ghqgdlstfl
      901 hqegkrekit prngelfhcv senehgaptr kdmvrssfvt rhsripvlaq eidstlesss
      961 pvsakekllq kkayqpdlvk llvekrqfks flgdlssasd klleeklatv papfceeevl
     1021 tpfsrltvds hlsrsaedsf lspiisqsrk skiprpvswv ntdqvnssts sqffprpppg
     1081 kpptrpgvea rlrrykvlgs snsdsdlfsr laqilqngsq kprsttqcks pgsphnpktp
     1141 pkspvvprrs psasprsssl prtsssspsr agrphhdqrs ssphlgrsks ppshsgssss
     1201 rrscqqehck psknglkgsg slhhhsastk tpqgkskpas klsr
//
LOCUS       XP_047288146            1244 aa            linear   PRI 05-AUG-2025
DEFINITION  tau-tubulin kinase 2 isoform X2 [Homo sapiens].
ACCESSION   XP_047288146
VERSION     XP_047288146.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432190.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1244
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1244
                     /product="tau-tubulin kinase 2 isoform X2"
                     /calculated_mol_wt=137282
     Region          20..281
                     /region_name="STKc_TTBK2"
                     /note="Catalytic domain of the Serine/Threonine protein
                     kinase, Tau-Tubulin Kinase 2; cd14129"
                     /db_xref="CDD:271031"
     Site            order(27..31,35,48,50,78,94..97,100,102,141,143,145..146,
                     148,163,166,188..191)
                     /site_type="active"
                     /db_xref="CDD:271031"
     Site            order(27..31,35,48,50,78,94..97,100,141,143,145..146,148,
                     163)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271031"
     Site            order(31,100,102,141,143,145,166,188..191)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:271031"
     Site            order(162..168,188..191)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:271031"
     CDS             1..1244
                     /gene="TTBK2"
                     /gene_synonym="SCA11; TTBK"
                     /coded_by="XM_047432190.1:84..3818"
                     /db_xref="GeneID:146057"
                     /db_xref="HGNC:HGNC:19141"
                     /db_xref="MIM:611695"
ORIGIN      
        1 msgggeqldi lsvgilvker wkvlrkiggg gfgeiydald mltrenvalk vesaqqpkqv
       61 lkmevavlkk lqgkdhvcrf igcgrndrfn yvvmqlqgrn ladlrrsqsr gtftisttlr
      121 lgrqilesie sihsvgflhr dikpsnfamg rfpstcrkcy mldfglarqf tnscgdvrpp
      181 ravagfrgtv ryasinahrn remgrhddlw slfymlvefv vgqlpwrkik dkeqvgsike
      241 rydhrlmlkh lppefsifld hissldyftk pdyqlltsvf dnsiktfgvi esdpfdwekt
      301 gndgsltttt tsttpqlhtr ltpaaigian atpipgdllr entdevfpde qlsdgengip
      361 vgvspdklpg slghprpqek dvweemdank nkiklgicka ateeenshgq angllnapsl
      421 gspirvrsei tqpdrdiplv rklrsihsfe lekrltlepk pdtdkfletc lekmqkdtsa
      481 gkesilpall hkpcvpavsr tdhiwhydee ylpdaskpas antpeqadgg gsngfiavnl
      541 ssckqeidsk ewvivdkeqd lqdfrtneav ghkttgspsd eepevlqvle aspqdeklql
      601 gpwaendhlk ketsgvvlal saegpptaas eqytdrlelq pgaasqfiaa tptslmeaqa
      661 egpltaitip rpsvastqst sgsfhcgqqp ekkdlqpmep tvelyspren fsglvvtege
      721 ppsggsrtdl glqidhighd mlpniresnk sqdlgpkelp dhnrlvvref enlpgeteek
      781 sillesdned eklsrgqhci eisslpgdlv ivekdhsatt epldvtktqt fsvvpnqdkn
      841 neimklltvg tseissrdid phvegqigqv aemqknkisk dddimsedlp ghqgdlstfl
      901 hqegkrekit prngelfhcv senehgaptr kdmvrssfvt rhsripvlaq eidstlesss
      961 pvsakekllq kkayqpdlvk llvekrqfks flgdlssasd klleeklatv papfceeevl
     1021 tpfsrltvds hlsrsaedsf lspiisqsrk skiprpvswv ntdqvnssts sqffprpppg
     1081 kpptrpgvea rlrrykvlgs snsdsdlfsr laqilqngsq kprsttqcks pgsphnpktp
     1141 pkspvvprrs psasprsssl prtsssspsr agrphhdqrs ssphlgrsks ppshsgssss
     1201 rrscqqehck psknglkgsg slhhhsastk tpqgkskpas klsr
//
LOCUS       XP_047288147            1244 aa            linear   PRI 05-AUG-2025
DEFINITION  tau-tubulin kinase 2 isoform X2 [Homo sapiens].
ACCESSION   XP_047288147
VERSION     XP_047288147.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432191.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1244
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1244
                     /product="tau-tubulin kinase 2 isoform X2"
                     /calculated_mol_wt=137282
     Region          20..281
                     /region_name="STKc_TTBK2"
                     /note="Catalytic domain of the Serine/Threonine protein
                     kinase, Tau-Tubulin Kinase 2; cd14129"
                     /db_xref="CDD:271031"
     Site            order(27..31,35,48,50,78,94..97,100,102,141,143,145..146,
                     148,163,166,188..191)
                     /site_type="active"
                     /db_xref="CDD:271031"
     Site            order(27..31,35,48,50,78,94..97,100,141,143,145..146,148,
                     163)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271031"
     Site            order(31,100,102,141,143,145,166,188..191)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:271031"
     Site            order(162..168,188..191)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:271031"
     CDS             1..1244
                     /gene="TTBK2"
                     /gene_synonym="SCA11; TTBK"
                     /coded_by="XM_047432191.1:86..3820"
                     /db_xref="GeneID:146057"
                     /db_xref="HGNC:HGNC:19141"
                     /db_xref="MIM:611695"
ORIGIN      
        1 msgggeqldi lsvgilvker wkvlrkiggg gfgeiydald mltrenvalk vesaqqpkqv
       61 lkmevavlkk lqgkdhvcrf igcgrndrfn yvvmqlqgrn ladlrrsqsr gtftisttlr
      121 lgrqilesie sihsvgflhr dikpsnfamg rfpstcrkcy mldfglarqf tnscgdvrpp
      181 ravagfrgtv ryasinahrn remgrhddlw slfymlvefv vgqlpwrkik dkeqvgsike
      241 rydhrlmlkh lppefsifld hissldyftk pdyqlltsvf dnsiktfgvi esdpfdwekt
      301 gndgsltttt tsttpqlhtr ltpaaigian atpipgdllr entdevfpde qlsdgengip
      361 vgvspdklpg slghprpqek dvweemdank nkiklgicka ateeenshgq angllnapsl
      421 gspirvrsei tqpdrdiplv rklrsihsfe lekrltlepk pdtdkfletc lekmqkdtsa
      481 gkesilpall hkpcvpavsr tdhiwhydee ylpdaskpas antpeqadgg gsngfiavnl
      541 ssckqeidsk ewvivdkeqd lqdfrtneav ghkttgspsd eepevlqvle aspqdeklql
      601 gpwaendhlk ketsgvvlal saegpptaas eqytdrlelq pgaasqfiaa tptslmeaqa
      661 egpltaitip rpsvastqst sgsfhcgqqp ekkdlqpmep tvelyspren fsglvvtege
      721 ppsggsrtdl glqidhighd mlpniresnk sqdlgpkelp dhnrlvvref enlpgeteek
      781 sillesdned eklsrgqhci eisslpgdlv ivekdhsatt epldvtktqt fsvvpnqdkn
      841 neimklltvg tseissrdid phvegqigqv aemqknkisk dddimsedlp ghqgdlstfl
      901 hqegkrekit prngelfhcv senehgaptr kdmvrssfvt rhsripvlaq eidstlesss
      961 pvsakekllq kkayqpdlvk llvekrqfks flgdlssasd klleeklatv papfceeevl
     1021 tpfsrltvds hlsrsaedsf lspiisqsrk skiprpvswv ntdqvnssts sqffprpppg
     1081 kpptrpgvea rlrrykvlgs snsdsdlfsr laqilqngsq kprsttqcks pgsphnpktp
     1141 pkspvvprrs psasprsssl prtsssspsr agrphhdqrs ssphlgrsks ppshsgssss
     1201 rrscqqehck psknglkgsg slhhhsastk tpqgkskpas klsr
//
LOCUS       XP_006720465            1239 aa            linear   PRI 05-AUG-2025
DEFINITION  tau-tubulin kinase 2 isoform X3 [Homo sapiens].
ACCESSION   XP_006720465
VERSION     XP_006720465.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720402.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1239
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1239
                     /product="tau-tubulin kinase 2 isoform X3"
                     /calculated_mol_wt=136788
     Region          64..276
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..1239
                     /gene="TTBK2"
                     /gene_synonym="SCA11; TTBK"
                     /coded_by="XM_006720402.5:69..3788"
                     /db_xref="GeneID:146057"
                     /db_xref="HGNC:HGNC:19141"
                     /db_xref="MIM:611695"
ORIGIN      
        1 mglanrrcef gthspistcs gevkwkpplg tgclcscsti svycnewgrr aagypecwnp
       61 serkmesgkd hvcrfigcgr ndrfnyvvmq lqgrnladlr rsqsrgtfti sttlrlgrqi
      121 lesiesihsv gflhrdikps nfamgrfpst crkcymldfg larqftnscg dvrppravag
      181 frgtvryasi nahrnremgr hddlwslfym lvefvvgqlp wrkikdkeqv gsikerydhr
      241 lmlkhlppef sifldhissl dyftkpdyql ltsvfdnsik tfgviesdpf dwektgndgs
      301 ltttttsttp qlhtrltpaa igianatpip gdllrentde vfpdeqlsdg engipvgvsp
      361 dklpgslghp rpqekdvwee mdanknkikl gickaateee nshgqangll napslgspir
      421 vrseitqpdr diplvrklrs ihsfelekrl tlepkpdtdk fletclekmq kdtsagkesi
      481 lpallhkpcv pavsrtdhiw hydeeylpda skpasantpe qadgggsngf iavnlssckq
      541 eidskewviv dkeqdlqdfr tneavghktt gspsdeepev lqvleaspqd eklqlgpwae
      601 ndhlkketsg vvlalsaegp ptaaseqytd rlelqpgaas qfiaatptsl meaqaegplt
      661 aitiprpsva stqstsgsfh cgqqpekkdl qpmeptvely sprenfsglv vtegeppsgg
      721 srtdlglqid highdmlpni resnksqdlg pkelpdhnrl vvrefenlpg eteeksille
      781 sdnedeklsr gqhcieissl pgdlvivekd hsattepldv tktqtfsvvp nqdknneimk
      841 lltvgtseis srdidphveg qigqvaemqk nkiskdddim sedlpghqgd lstflhqegk
      901 rekitprnge lfhcvseneh gaptrkdmvr ssfvtrhsri pvlaqeidst lessspvsak
      961 ekllqkkayq pdlvkllvek rqfksflgdl ssasdkllee klatvpapfc eeevltpfsr
     1021 ltvdshlsrs aedsflspii sqsrkskipr pvswvntdqv nsstssqffp rpppgkpptr
     1081 pgvearlrry kvlgssnsds dlfsrlaqil qngsqkprst tqckspgsph npktppkspv
     1141 vprrspsasp rssslprtss sspsragrph hdqrsssphl grsksppshs gssssrrscq
     1201 qehckpskng lkgsgslhhh sastktpqgk skpasklsr
//
LOCUS       XP_006720466            1175 aa            linear   PRI 05-AUG-2025
DEFINITION  tau-tubulin kinase 2 isoform X4 [Homo sapiens].
ACCESSION   XP_006720466
VERSION     XP_006720466.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720403.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1175
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1175
                     /product="tau-tubulin kinase 2 isoform X4"
                     /calculated_mol_wt=129730
     Region          2..212
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..1175
                     /gene="TTBK2"
                     /gene_synonym="SCA11; TTBK"
                     /coded_by="XM_006720403.5:237..3764"
                     /db_xref="GeneID:146057"
                     /db_xref="HGNC:HGNC:19141"
                     /db_xref="MIM:611695"
ORIGIN      
        1 mlpgkdhvcr figcgrndrf nyvvmqlqgr nladlrrsqs rgtftisttl rlgrqilesi
       61 esihsvgflh rdikpsnfam grfpstcrkc ymldfglarq ftnscgdvrp pravagfrgt
      121 vryasinahr nremgrhddl wslfymlvef vvgqlpwrki kdkeqvgsik erydhrlmlk
      181 hlppefsifl dhissldyft kpdyqlltsv fdnsiktfgv iesdpfdwek tgndgslttt
      241 ttsttpqlht rltpaaigia natpipgdll rentdevfpd eqlsdgengi pvgvspdklp
      301 gslghprpqe kdvweemdan knkiklgick aateeenshg qangllnaps lgspirvrse
      361 itqpdrdipl vrklrsihsf elekrltlep kpdtdkflet clekmqkdts agkesilpal
      421 lhkpcvpavs rtdhiwhyde eylpdaskpa santpeqadg ggsngfiavn lssckqeids
      481 kewvivdkeq dlqdfrtnea vghkttgsps deepevlqvl easpqdeklq lgpwaendhl
      541 kketsgvvla lsaegpptaa seqytdrlel qpgaasqfia atptslmeaq aegpltaiti
      601 prpsvastqs tsgsfhcgqq pekkdlqpme ptvelyspre nfsglvvteg eppsggsrtd
      661 lglqidhigh dmlpniresn ksqdlgpkel pdhnrlvvre fenlpgetee ksillesdne
      721 deklsrgqhc ieisslpgdl vivekdhsat tepldvtktq tfsvvpnqdk nneimklltv
      781 gtseissrdi dphvegqigq vaemqknkis kdddimsedl pghqgdlstf lhqegkreki
      841 tprngelfhc vsenehgapt rkdmvrssfv trhsripvla qeidstless spvsakekll
      901 qkkayqpdlv kllvekrqfk sflgdlssas dklleeklat vpapfceeev ltpfsrltvd
      961 shlsrsaeds flspiisqsr kskiprpvsw vntdqvnsst ssqffprppp gkpptrpgve
     1021 arlrrykvlg ssnsdsdlfs rlaqilqngs qkprsttqck spgsphnpkt ppkspvvprr
     1081 spsasprsss lprtssssps ragrphhdqr sssphlgrsk sppshsgsss srrscqqehc
     1141 kpsknglkgs gslhhhsast ktpqgkskpa sklsr
//
LOCUS       XP_016877439            1151 aa            linear   PRI 05-AUG-2025
DEFINITION  tau-tubulin kinase 2 isoform X5 [Homo sapiens].
ACCESSION   XP_016877439
VERSION     XP_016877439.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021950.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1151
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1151
                     /product="tau-tubulin kinase 2 isoform X5"
                     /calculated_mol_wt=126951
     Region          <1..188
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..1151
                     /gene="TTBK2"
                     /gene_synonym="SCA11; TTBK"
                     /coded_by="XM_017021950.3:85..3540"
                     /db_xref="GeneID:146057"
                     /db_xref="HGNC:HGNC:19141"
                     /db_xref="MIM:611695"
ORIGIN      
        1 mqlqgrnlad lrrsqsrgtf tisttlrlgr qilesiesih svgflhrdik psnfamgrfp
       61 stcrkcymld fglarqftns cgdvrpprav agfrgtvrya sinahrnrem grhddlwslf
      121 ymlvefvvgq lpwrkikdke qvgsikeryd hrlmlkhlpp efsifldhis sldyftkpdy
      181 qlltsvfdns iktfgviesd pfdwektgnd gsltttttst tpqlhtrltp aaigianatp
      241 ipgdllrent devfpdeqls dgengipvgv spdklpgslg hprpqekdvw eemdanknki
      301 klgickaate eenshgqang llnapslgsp irvrseitqp drdiplvrkl rsihsfelek
      361 rltlepkpdt dkfletclek mqkdtsagke silpallhkp cvpavsrtdh iwhydeeylp
      421 daskpasant peqadgggsn gfiavnlssc kqeidskewv ivdkeqdlqd frtneavghk
      481 ttgspsdeep evlqvleasp qdeklqlgpw aendhlkket sgvvlalsae gpptaaseqy
      541 tdrlelqpga asqfiaatpt slmeaqaegp ltaitiprps vastqstsgs fhcgqqpekk
      601 dlqpmeptve lysprenfsg lvvtegepps ggsrtdlglq idhighdmlp niresnksqd
      661 lgpkelpdhn rlvvrefenl pgeteeksil lesdnedekl srgqhcieis slpgdlvive
      721 kdhsattepl dvtktqtfsv vpnqdknnei mklltvgtse issrdidphv egqigqvaem
      781 qknkiskddd imsedlpghq gdlstflhqe gkrekitprn gelfhcvsen ehgaptrkdm
      841 vrssfvtrhs ripvlaqeid stlessspvs akekllqkka yqpdlvkllv ekrqfksflg
      901 dlssasdkll eeklatvpap fceeevltpf srltvdshls rsaedsflsp iisqsrkski
      961 prpvswvntd qvnsstssqf fprpppgkpp trpgvearlr rykvlgssns dsdlfsrlaq
     1021 ilqngsqkpr sttqckspgs phnpktppks pvvprrspsa sprssslprt sssspsragr
     1081 phhdqrsssp hlgrskspps hsgssssrrs cqqehckpsk nglkgsgslh hhsastktpq
     1141 gkskpaskls r
//
LOCUS       XP_005254230            1175 aa            linear   PRI 05-AUG-2025
DEFINITION  tau-tubulin kinase 2 isoform X6 [Homo sapiens].
ACCESSION   XP_005254230
VERSION     XP_005254230.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254173.6
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 3% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1175
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1175
                     /product="tau-tubulin kinase 2 isoform X6"
                     /calculated_mol_wt=129736
     Region          <4..212
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..1175
                     /gene="TTBK2"
                     /gene_synonym="SCA11; TTBK"
                     /coded_by="XM_005254173.6:468..3995"
                     /db_xref="GeneID:146057"
                     /db_xref="HGNC:HGNC:19141"
                     /db_xref="MIM:611695"
ORIGIN      
        1 mesgkdhvcr figcgrndrf nyvvmqlqgr nladlrrsqs rgtftisttl rlgrqilesi
       61 esihsvgflh rdikpsnfam grfpstcrkc ymldfglarq ftnscgdvrp pravagfrgt
      121 vryasinahr nremgrhddl wslfymlvef vvgqlpwrki kdkeqvgsik erydhrlmlk
      181 hlppefsifl dhissldyft kpdyqlltsv fdnsiktfgv iesdpfdwek tgndgslttt
      241 ttsttpqlht rltpaaigia natpipgdll rentdevfpd eqlsdgengi pvgvspdklp
      301 gslghprpqe kdvweemdan knkiklgick aateeenshg qangllnaps lgspirvrse
      361 itqpdrdipl vrklrsihsf elekrltlep kpdtdkflet clekmqkdts agkesilpal
      421 lhkpcvpavs rtdhiwhyde eylpdaskpa santpeqadg ggsngfiavn lssckqeids
      481 kewvivdkeq dlqdfrtnea vghkttgsps deepevlqvl easpqdeklq lgpwaendhl
      541 kketsgvvla lsaegpptaa seqytdrlel qpgaasqfia atptslmeaq aegpltaiti
      601 prpsvastqs tsgsfhcgqq pekkdlqpme ptvelyspre nfsglvvteg eppsggsrtd
      661 lglqidhigh dmlpniresn ksqdlgpkel pdhnrlvvre fenlpgetee ksillesdne
      721 deklsrgqhc ieisslpgdl vivekdhsat tepldvtktq tfsvvpnqdk nneimklltv
      781 gtseissrdi dphvegqigq vaemqknkis kdddimsedl pghqgdlstf lhqegkreki
      841 tprngelfhc vsenehgapt rkdmvrssfv trhsripvla qeidstless spvsakekll
      901 qkkayqpdlv kllvekrqfk sflgdlssas dklleeklat vpapfceeev ltpfsrltvd
      961 shlsrsaeds flspiisqsr kskiprpvsw vntdqvnsst ssqffprppp gkpptrpgve
     1021 arlrrykvlg ssnsdsdlfs rlaqilqngs qkprsttqck spgsphnpkt ppkspvvprr
     1081 spsasprsss lprtssssps ragrphhdqr sssphlgrsk sppshsgsss srrscqqehc
     1141 kpsknglkgs gslhhhsast ktpqgkskpa sklsr
//
LOCUS       XP_047288148             859 aa            linear   PRI 05-AUG-2025
DEFINITION  tau-tubulin kinase 2 isoform X7 [Homo sapiens].
ACCESSION   XP_047288148
VERSION     XP_047288148.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432192.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..859
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..859
                     /product="tau-tubulin kinase 2 isoform X7"
                     /calculated_mol_wt=93901
     CDS             1..859
                     /gene="TTBK2"
                     /gene_synonym="SCA11; TTBK"
                     /coded_by="XM_047432192.1:1830..4409"
                     /db_xref="GeneID:146057"
                     /db_xref="HGNC:HGNC:19141"
                     /db_xref="MIM:611695"
ORIGIN      
        1 mdanknkikl gickaateee nshgqangll napslgspir vrseitqpdr diplvrklrs
       61 ihsfelekrl tlepkpdtdk fletclekmq kdtsagkesi lpallhkpcv pavsrtdhiw
      121 hydeeylpda skpasantpe qadgggsngf iavnlssckq eidskewviv dkeqdlqdfr
      181 tneavghktt gspsdeepev lqvleaspqd eklqlgpwae ndhlkketsg vvlalsaegp
      241 ptaaseqytd rlelqpgaas qfiaatptsl meaqaegplt aitiprpsva stqstsgsfh
      301 cgqqpekkdl qpmeptvely sprenfsglv vtegeppsgg srtdlglqid highdmlpni
      361 resnksqdlg pkelpdhnrl vvrefenlpg eteeksille sdnedeklsr gqhcieissl
      421 pgdlvivekd hsattepldv tktqtfsvvp nqdknneimk lltvgtseis srdidphveg
      481 qigqvaemqk nkiskdddim sedlpghqgd lstflhqegk rekitprnge lfhcvseneh
      541 gaptrkdmvr ssfvtrhsri pvlaqeidst lessspvsak ekllqkkayq pdlvkllvek
      601 rqfksflgdl ssasdkllee klatvpapfc eeevltpfsr ltvdshlsrs aedsflspii
      661 sqsrkskipr pvswvntdqv nsstssqffp rpppgkpptr pgvearlrry kvlgssnsds
      721 dlfsrlaqil qngsqkprst tqckspgsph npktppkspv vprrspsasp rssslprtss
      781 sspsragrph hdqrsssphl grsksppshs gssssrrscq qehckpskng lkgsgslhhh
      841 sastktpqgk skpasklsr
//
LOCUS       XP_011519572            1236 aa            linear   PRI 05-AUG-2025
DEFINITION  codanin-1 isoform X1 [Homo sapiens].
ACCESSION   XP_011519572
VERSION     XP_011519572.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521270.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1236
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1236
                     /product="codanin-1 isoform X1"
                     /calculated_mol_wt=134998
     Region          793..908
                     /region_name="Codanin-1_C"
                     /note="Codanin-1 C-terminus; pfam15296"
                     /db_xref="CDD:464622"
     CDS             1..1236
                     /gene="CDAN1"
                     /gene_synonym="CDA1; CDAI; CDAN1A; DLT; PRO1295"
                     /coded_by="XM_011521270.3:27..3737"
                     /db_xref="GeneID:146059"
                     /db_xref="HGNC:HGNC:1713"
                     /db_xref="MIM:607465"
ORIGIN      
        1 maavlesllr eevsvaavvr wiarstqgse vtavtrpqdn ageaaalssl ralrkefvpf
       61 llnflreqss rvlpqgpptp aktpgasaal pgrpggpprg srgarsqlfp pteaqstaae
      121 aplarrggrr rgpgparerg grgleegvsg eslpgaggrr lrgsgspsrp sltlsdppnl
      181 snleefppvg svppgptgrt kpsrrinptp vseerslskp ktcftsppis cvpssqpsal
      241 dtspwglglp pgcrslqeer emlrkerskq lqqsptptcp tpelgsplps rtgsltdepa
      301 dparvssrqr lelvalvyss ciaenlvpnl flelffvfql ltarrmvtak dsdpelspav
      361 ldslesplfq sihdcvffav qvlechfqvl snldkgtlkl laenerllcf spalqgrlra
      421 ayegsvakvs lvmppstqav sfqpetdnra nfssdrafht fkkqrdvfye vlrewedhhe
      481 epgwdfekgl gsrirammgq lsaacshshf vrlfqkqllq mcqspggagg tvlgeapdvl
      541 smlgadklgr lwrlqerlma pqssggpcpp ptfpgcqgff rdfilsassf qfnqhlmdsl
      601 slkiqelngl alpqhepnde dgesdvdwqg erkqfavvll slrllakflg fvaflpyrgp
      661 eppptgelqd silalrsqvp pvldvrtllq rglqarravl tvpwlvefls fadhvvplle
      721 yyrdiftlll rlhrslvlsq esegkmcfln kllllavlgw lfqiptvped lffleegpsy
      781 afevdtvape hgldnapvvd qqllytccpy igelrkllas wvsgssgrsg gfmrkitptt
      841 ttslgaqpsq tsqglqaqla qaffhnqpps lrrtvefvae rigsncvkhi katlvadlvr
      901 qaesllqeql vtqgeeggdp aqlleilcsq lcphgaqala lgrefcqrks pgavrallpe
      961 etpaavlssa eniavglate kacawlsani talirrevka avsrtlraqg pepaargerr
     1021 gcsracehha plpshlisei kdvlslavgp rdpdegvspe hleqllgqlg qtlrcrqflc
     1081 ppaeqhlakc svelasllva dqipilgppa qyrlergqar rllhmllslw kedfqgpvpl
     1141 qlllsprnvg lladtrprew dlllfllrel vekglmgrme ieaclgslhq aqwpgdfaee
     1201 latlsnlfla ephlpepqlr acelvqpnrg tvlaqs
//
LOCUS       XP_011519573            1235 aa            linear   PRI 05-AUG-2025
DEFINITION  codanin-1 isoform X2 [Homo sapiens].
ACCESSION   XP_011519573
VERSION     XP_011519573.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521271.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1235
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1235
                     /product="codanin-1 isoform X2"
                     /calculated_mol_wt=134842
     Region          792..907
                     /region_name="Codanin-1_C"
                     /note="Codanin-1 C-terminus; pfam15296"
                     /db_xref="CDD:464622"
     CDS             1..1235
                     /gene="CDAN1"
                     /gene_synonym="CDA1; CDAI; CDAN1A; DLT; PRO1295"
                     /coded_by="XM_011521271.3:27..3734"
                     /db_xref="GeneID:146059"
                     /db_xref="HGNC:HGNC:1713"
                     /db_xref="MIM:607465"
ORIGIN      
        1 maavlesllr eevsvaavvr wiarstqgse vtavtrpqdn ageaaalssl ralrkefvpf
       61 llnflreqss rvlpqgpptp aktpgasaal pgrpggpprg srgarsqlfp pteaqstaae
      121 aplarrggrr rgpgparerg grgleegvsg eslpgaggrr lrgsgspsrp sltlsdppnl
      181 snleefppvg svppgptgtk psrrinptpv seerslskpk tcftsppisc vpssqpsald
      241 tspwglglpp gcrslqeere mlrkerskql qqsptptcpt pelgsplpsr tgsltdepad
      301 parvssrqrl elvalvyssc iaenlvpnlf lelffvfqll tarrmvtakd sdpelspavl
      361 dslesplfqs ihdcvffavq vlechfqvls nldkgtlkll aenerllcfs palqgrlraa
      421 yegsvakvsl vmppstqavs fqpetdnran fssdrafhtf kkqrdvfyev lrewedhhee
      481 pgwdfekglg srirammgql saacshshfv rlfqkqllqm cqspggaggt vlgeapdvls
      541 mlgadklgrl wrlqerlmap qssggpcppp tfpgcqgffr dfilsassfq fnqhlmdsls
      601 lkiqelngla lpqhepnded gesdvdwqge rkqfavvlls lrllakflgf vaflpyrgpe
      661 ppptgelqds ilalrsqvpp vldvrtllqr glqarravlt vpwlveflsf adhvvplley
      721 yrdiftlllr lhrslvlsqe segkmcflnk llllavlgwl fqiptvpedl ffleegpsya
      781 fevdtvapeh gldnapvvdq qllytccpyi gelrkllasw vsgssgrsgg fmrkitpttt
      841 tslgaqpsqt sqglqaqlaq affhnqppsl rrtvefvaer igsncvkhik atlvadlvrq
      901 aesllqeqlv tqgeeggdpa qlleilcsql cphgaqalal grefcqrksp gavrallpee
      961 tpaavlssae niavglatek acawlsanit alirrevkaa vsrtlraqgp epaargerrg
     1021 csracehhap lpshliseik dvlslavgpr dpdegvspeh leqllgqlgq tlrcrqflcp
     1081 paeqhlakcs velasllvad qipilgppaq yrlergqarr llhmllslwk edfqgpvplq
     1141 lllsprnvgl ladtrprewd lllfllrelv ekglmgrmei eaclgslhqa qwpgdfaeel
     1201 atlsnlflae phlpepqlra celvqpnrgt vlaqs
//
LOCUS       XP_005254233            1228 aa            linear   PRI 05-AUG-2025
DEFINITION  codanin-1 isoform X3 [Homo sapiens].
ACCESSION   XP_005254233
VERSION     XP_005254233.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254176.6
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1228
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1228
                     /product="codanin-1 isoform X3"
                     /calculated_mol_wt=134145
     Region          785..900
                     /region_name="Codanin-1_C"
                     /note="Codanin-1 C-terminus; pfam15296"
                     /db_xref="CDD:464622"
     CDS             1..1228
                     /gene="CDAN1"
                     /gene_synonym="CDA1; CDAI; CDAN1A; DLT; PRO1295"
                     /coded_by="XM_005254176.6:27..3713"
                     /db_xref="GeneID:146059"
                     /db_xref="HGNC:HGNC:1713"
                     /db_xref="MIM:607465"
ORIGIN      
        1 maavlesllr eevsvaavvr wiarstqgse dnageaaals slralrkefv pfllnflreq
       61 ssrvlpqgpp tpaktpgasa alpgrpggpp rgsrgarsql fppteaqsta aeaplarrgg
      121 rrrgpgpare rggrgleegv sgeslpgagg rrlrgsgsps rpsltlsdpp nlsnleefpp
      181 vgsvppgptg rtkpsrrinp tpvseersls kpktcftspp iscvpssqps aldtspwglg
      241 lppgcrslqe eremlrkers kqlqqsptpt cptpelgspl psrtgsltde padparvssr
      301 qrlelvalvy ssciaenlvp nlflelffvf qlltarrmvt akdsdpelsp avldslespl
      361 fqsihdcvff avqvlechfq vlsnldkgtl kllaenerll cfspalqgrl raayegsvak
      421 vslvmppstq avsfqpetdn ranfssdraf htfkkqrdvf yevlrewedh heepgwdfek
      481 glgsriramm gqlsaacshs hfvrlfqkql lqmcqspgga ggtvlgeapd vlsmlgadkl
      541 grlwrlqerl mapqssggpc ppptfpgcqg ffrdfilsas sfqfnqhlmd slslkiqeln
      601 glalpqhepn dedgesdvdw qgerkqfavv llslrllakf lgfvaflpyr gpeppptgel
      661 qdsilalrsq vppvldvrtl lqrglqarra vltvpwlvef lsfadhvvpl leyyrdiftl
      721 llrlhrslvl sqesegkmcf lnkllllavl gwlfqiptvp edlffleegp syafevdtva
      781 pehgldnapv vdqqllytcc pyigelrkll aswvsgssgr sggfmrkitp ttttslgaqp
      841 sqtsqglqaq laqaffhnqp pslrrtvefv aerigsncvk hikatlvadl vrqaesllqe
      901 qlvtqgeegg dpaqlleilc sqlcphgaqa lalgrefcqr kspgavrall peetpaavls
      961 saeniavgla tekacawlsa nitalirrev kaavsrtlra qgpepaarge rrgcsraceh
     1021 haplpshlis eikdvlslav gprdpdegvs pehleqllgq lgqtlrcrqf lcppaeqhla
     1081 kcsvelasll vadqipilgp paqyrlergq arrllhmlls lwkedfqgpv plqlllsprn
     1141 vglladtrpr ewdlllfllr elvekglmgr meieaclgsl hqaqwpgdfa eelatlsnlf
     1201 laephlpepq lracelvqpn rgtvlaqs
//
LOCUS       XP_047288149            1084 aa            linear   PRI 05-AUG-2025
DEFINITION  codanin-1 isoform X4 [Homo sapiens].
ACCESSION   XP_047288149
VERSION     XP_047288149.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432193.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1084
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1084
                     /product="codanin-1 isoform X4"
                     /calculated_mol_wt=118003
     Region          793..908
                     /region_name="Codanin-1_C"
                     /note="Codanin-1 C-terminus; pfam15296"
                     /db_xref="CDD:464622"
     CDS             1..1084
                     /gene="CDAN1"
                     /gene_synonym="CDA1; CDAI; CDAN1A; DLT; PRO1295"
                     /coded_by="XM_047432193.1:27..3281"
                     /db_xref="GeneID:146059"
                     /db_xref="HGNC:HGNC:1713"
                     /db_xref="MIM:607465"
ORIGIN      
        1 maavlesllr eevsvaavvr wiarstqgse vtavtrpqdn ageaaalssl ralrkefvpf
       61 llnflreqss rvlpqgpptp aktpgasaal pgrpggpprg srgarsqlfp pteaqstaae
      121 aplarrggrr rgpgparerg grgleegvsg eslpgaggrr lrgsgspsrp sltlsdppnl
      181 snleefppvg svppgptgrt kpsrrinptp vseerslskp ktcftsppis cvpssqpsal
      241 dtspwglglp pgcrslqeer emlrkerskq lqqsptptcp tpelgsplps rtgsltdepa
      301 dparvssrqr lelvalvyss ciaenlvpnl flelffvfql ltarrmvtak dsdpelspav
      361 ldslesplfq sihdcvffav qvlechfqvl snldkgtlkl laenerllcf spalqgrlra
      421 ayegsvakvs lvmppstqav sfqpetdnra nfssdrafht fkkqrdvfye vlrewedhhe
      481 epgwdfekgl gsrirammgq lsaacshshf vrlfqkqllq mcqspggagg tvlgeapdvl
      541 smlgadklgr lwrlqerlma pqssggpcpp ptfpgcqgff rdfilsassf qfnqhlmdsl
      601 slkiqelngl alpqhepnde dgesdvdwqg erkqfavvll slrllakflg fvaflpyrgp
      661 eppptgelqd silalrsqvp pvldvrtllq rglqarravl tvpwlvefls fadhvvplle
      721 yyrdiftlll rlhrslvlsq esegkmcfln kllllavlgw lfqiptvped lffleegpsy
      781 afevdtvape hgldnapvvd qqllytccpy igelrkllas wvsgssgrsg gfmrkitptt
      841 ttslgaqpsq tsqglqaqla qaffhnqpps lrrtvefvae rigsncvkhi katlvadlvr
      901 qaesllqeql vtqgeeggdp aqlleilcsq lcphgaqala lgrefcqrks pgavrallpe
      961 etpaavlssa eniavglate kacawlsani talirrevka avsrtlraqg pepaargerr
     1021 gcsracehha plpshlisei kdvlslavgp rdpdegvspe hleqllgqlg qtlrcrqlqi
     1081 kfls
//
LOCUS       XP_047288150            1025 aa            linear   PRI 05-AUG-2025
DEFINITION  codanin-1 isoform X5 [Homo sapiens].
ACCESSION   XP_047288150
VERSION     XP_047288150.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432194.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1025
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1025
                     /product="codanin-1 isoform X5"
                     /calculated_mol_wt=111471
     Region          793..908
                     /region_name="Codanin-1_C"
                     /note="Codanin-1 C-terminus; pfam15296"
                     /db_xref="CDD:464622"
     CDS             1..1025
                     /gene="CDAN1"
                     /gene_synonym="CDA1; CDAI; CDAN1A; DLT; PRO1295"
                     /coded_by="XM_047432194.1:27..3104"
                     /db_xref="GeneID:146059"
                     /db_xref="HGNC:HGNC:1713"
                     /db_xref="MIM:607465"
ORIGIN      
        1 maavlesllr eevsvaavvr wiarstqgse vtavtrpqdn ageaaalssl ralrkefvpf
       61 llnflreqss rvlpqgpptp aktpgasaal pgrpggpprg srgarsqlfp pteaqstaae
      121 aplarrggrr rgpgparerg grgleegvsg eslpgaggrr lrgsgspsrp sltlsdppnl
      181 snleefppvg svppgptgrt kpsrrinptp vseerslskp ktcftsppis cvpssqpsal
      241 dtspwglglp pgcrslqeer emlrkerskq lqqsptptcp tpelgsplps rtgsltdepa
      301 dparvssrqr lelvalvyss ciaenlvpnl flelffvfql ltarrmvtak dsdpelspav
      361 ldslesplfq sihdcvffav qvlechfqvl snldkgtlkl laenerllcf spalqgrlra
      421 ayegsvakvs lvmppstqav sfqpetdnra nfssdrafht fkkqrdvfye vlrewedhhe
      481 epgwdfekgl gsrirammgq lsaacshshf vrlfqkqllq mcqspggagg tvlgeapdvl
      541 smlgadklgr lwrlqerlma pqssggpcpp ptfpgcqgff rdfilsassf qfnqhlmdsl
      601 slkiqelngl alpqhepnde dgesdvdwqg erkqfavvll slrllakflg fvaflpyrgp
      661 eppptgelqd silalrsqvp pvldvrtllq rglqarravl tvpwlvefls fadhvvplle
      721 yyrdiftlll rlhrslvlsq esegkmcfln kllllavlgw lfqiptvped lffleegpsy
      781 afevdtvape hgldnapvvd qqllytccpy igelrkllas wvsgssgrsg gfmrkitptt
      841 ttslgaqpsq tsqglqaqla qaffhnqpps lrrtvefvae rigsncvkhi katlvadlvr
      901 qaesllqeql vtqgeeggdp aqlleilcsq lcphgaqala lgrefcqrks pgavrallpe
      961 etpaavlssa eniavglate kacawlsani talirrevka avsrtlraqg pepaargerr
     1021 gcsra
//
LOCUS       XP_047288151             891 aa            linear   PRI 05-AUG-2025
DEFINITION  codanin-1 isoform X6 [Homo sapiens].
ACCESSION   XP_047288151
VERSION     XP_047288151.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432195.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..891
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..891
                     /product="codanin-1 isoform X6"
                     /calculated_mol_wt=98345
     Region          448..563
                     /region_name="Codanin-1_C"
                     /note="Codanin-1 C-terminus; pfam15296"
                     /db_xref="CDD:464622"
     CDS             1..891
                     /gene="CDAN1"
                     /gene_synonym="CDA1; CDAI; CDAN1A; DLT; PRO1295"
                     /coded_by="XM_047432195.1:267..2942"
                     /db_xref="GeneID:146059"
                     /db_xref="HGNC:HGNC:1713"
                     /db_xref="MIM:607465"
ORIGIN      
        1 mvtakdsdpe lspavldsle splfqsihdc vffavqvlec hfqvlsnldk gtlkllaene
       61 rllcfspalq grlraayegs vakvslvmpp stqavsfqpe tdnranfssd rafhtfkkqr
      121 dvfyevlrew edhheepgwd fekglgsrir ammgqlsaac shshfvrlfq kqllqmcqsp
      181 ggaggtvlge apdvlsmlga dklgrlwrlq erlmapqssg gpcppptfpg cqgffrdfil
      241 sassfqfnqh lmdslslkiq elnglalpqh epndedgesd vdwqgerkqf avvllslrll
      301 akflgfvafl pyrgpepppt gelqdsilal rsqvppvldv rtllqrglqa rravltvpwl
      361 veflsfadhv vplleyyrdi ftlllrlhrs lvlsqesegk mcflnkllll avlgwlfqip
      421 tvpedlffle egpsyafevd tvapehgldn apvvdqqlly tccpyigelr kllaswvsgs
      481 sgrsggfmrk itpttttslg aqpsqtsqgl qaqlaqaffh nqppslrrtv efvaerigsn
      541 cvkhikatlv adlvrqaesl lqeqlvtqge eggdpaqlle ilcsqlcphg aqalalgref
      601 cqrkspgavr allpeetpaa vlssaeniav glatekacaw lsanitalir revkaavsrt
      661 lraqgpepaa rgerrgcsra cehhaplpsh liseikdvls lavgprdpde gvspehleql
      721 lgqlgqtlrc rqflcppaeq hlakcsvela sllvadqipi lgppaqyrle rgqarrllhm
      781 llslwkedfq gpvplqllls prnvglladt rprewdlllf llrelvekgl mgrmeieacl
      841 gslhqaqwpg dfaeelatls nlflaephlp epqlracelv qpnrgtvlaq s
//
LOCUS       XP_011519576             891 aa            linear   PRI 05-AUG-2025
DEFINITION  codanin-1 isoform X6 [Homo sapiens].
ACCESSION   XP_011519576
VERSION     XP_011519576.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521274.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..891
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..891
                     /product="codanin-1 isoform X6"
                     /calculated_mol_wt=98345
     Region          448..563
                     /region_name="Codanin-1_C"
                     /note="Codanin-1 C-terminus; pfam15296"
                     /db_xref="CDD:464622"
     CDS             1..891
                     /gene="CDAN1"
                     /gene_synonym="CDA1; CDAI; CDAN1A; DLT; PRO1295"
                     /coded_by="XM_011521274.3:112..2787"
                     /db_xref="GeneID:146059"
                     /db_xref="HGNC:HGNC:1713"
                     /db_xref="MIM:607465"
ORIGIN      
        1 mvtakdsdpe lspavldsle splfqsihdc vffavqvlec hfqvlsnldk gtlkllaene
       61 rllcfspalq grlraayegs vakvslvmpp stqavsfqpe tdnranfssd rafhtfkkqr
      121 dvfyevlrew edhheepgwd fekglgsrir ammgqlsaac shshfvrlfq kqllqmcqsp
      181 ggaggtvlge apdvlsmlga dklgrlwrlq erlmapqssg gpcppptfpg cqgffrdfil
      241 sassfqfnqh lmdslslkiq elnglalpqh epndedgesd vdwqgerkqf avvllslrll
      301 akflgfvafl pyrgpepppt gelqdsilal rsqvppvldv rtllqrglqa rravltvpwl
      361 veflsfadhv vplleyyrdi ftlllrlhrs lvlsqesegk mcflnkllll avlgwlfqip
      421 tvpedlffle egpsyafevd tvapehgldn apvvdqqlly tccpyigelr kllaswvsgs
      481 sgrsggfmrk itpttttslg aqpsqtsqgl qaqlaqaffh nqppslrrtv efvaerigsn
      541 cvkhikatlv adlvrqaesl lqeqlvtqge eggdpaqlle ilcsqlcphg aqalalgref
      601 cqrkspgavr allpeetpaa vlssaeniav glatekacaw lsanitalir revkaavsrt
      661 lraqgpepaa rgerrgcsra cehhaplpsh liseikdvls lavgprdpde gvspehleql
      721 lgqlgqtlrc rqflcppaeq hlakcsvela sllvadqipi lgppaqyrle rgqarrllhm
      781 llslwkedfq gpvplqllls prnvglladt rprewdlllf llrelvekgl mgrmeieacl
      841 gslhqaqwpg dfaeelatls nlflaephlp epqlracelv qpnrgtvlaq s
//
LOCUS       XP_047288152            1968 aa            linear   PRI 05-AUG-2025
DEFINITION  chondroitin sulfate proteoglycan 4 isoform X1 [Homo sapiens].
ACCESSION   XP_047288152
VERSION     XP_047288152.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432196.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1968
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1968
                     /product="chondroitin sulfate proteoglycan 4 isoform X1"
                     /calculated_mol_wt=212907
     Region          <82..169
                     /region_name="Cadherin_3"
                     /note="Cadherin-like; pfam16184"
                     /db_xref="CDD:465048"
     Region          182..291
                     /region_name="Cadherin_3"
                     /note="Cadherin-like; pfam16184"
                     /db_xref="CDD:465048"
     Region          <436..524
                     /region_name="Cadherin_3"
                     /note="Cadherin-like; pfam16184"
                     /db_xref="CDD:465048"
     Region          530..635
                     /region_name="Cadherin_3"
                     /note="Cadherin-like; pfam16184"
                     /db_xref="CDD:465048"
     Region          649..756
                     /region_name="Cadherin_3"
                     /note="Cadherin-like; pfam16184"
                     /db_xref="CDD:465048"
     Region          774..861
                     /region_name="Cadherin_3"
                     /note="Cadherin-like; pfam16184"
                     /db_xref="CDD:465048"
     Region          871..982
                     /region_name="Cadherin_3"
                     /note="Cadherin-like; pfam16184"
                     /db_xref="CDD:465048"
     Region          <1011..1092
                     /region_name="Cadherin_3"
                     /note="Cadherin-like; pfam16184"
                     /db_xref="CDD:465048"
     Region          1102..1209
                     /region_name="Cadherin_3"
                     /note="Cadherin-like; pfam16184"
                     /db_xref="CDD:465048"
     Region          <1356..1448
                     /region_name="Cadherin_3"
                     /note="Cadherin-like; pfam16184"
                     /db_xref="CDD:465048"
     Region          1461..1570
                     /region_name="Cadherin_3"
                     /note="Cadherin-like; pfam16184"
                     /db_xref="CDD:465048"
     Region          1687..1769
                     /region_name="Cadherin_3"
                     /note="Cadherin-like; pfam16184"
                     /db_xref="CDD:465048"
     CDS             1..1968
                     /gene="CSPG4"
                     /gene_synonym="CSPG4A; HMW-MAA; MCSP; MCSPG; MEL-CSPG;
                     MSK16; NG2"
                     /coded_by="XM_047432196.1:1061..6967"
                     /db_xref="GeneID:1464"
                     /db_xref="HGNC:HGNC:2466"
                     /db_xref="MIM:601172"
ORIGIN      
        1 medlsvngqr rglrealltr nmaagcrlee eeyeddaygh yeafstlape awpamelpep
       61 cvpepglppv fanftqllti splvvaeggt awlewrhvqp tldlmeaelr ksqvlfsvtr
      121 garhgeleld ipgaqarkmf tlldvvnrka rfihdgsedt sdqlvlevsv tarvpmpscl
      181 rrgqtyllpi qvnpvndpph iifphgslmv ilehtqkplg pevfqaydpd sacegltfqv
      241 lgtssglpve rrdqpgepat efscreleag slvyvhrggp aqdltfrvsd glqasppatl
      301 kvvairpaiq ihrstglrla qgsampilpa nlsvetnavg qdvsvlfrvt galqfgelqk
      361 qgaggvegae wwatqafhqr dveqgrvryl stdpqhhayd tvenlalevq vgqeilsnls
      421 fpvtiqratv wmlrleplht qntqqetltt ahleatleea gpspptfhye vvqaprkgnl
      481 qlqgtrlsdg qgftqddiqa grvtygatar aseavedtfr frvtappyfs plytfpihig
      541 gdpdapvltn vllvvpegge gvlsadhlfv kslnsasyly evmerprhgr lawrgtqdkt
      601 tmvtsftned llrgrlvyqh ddsetteddi pfvatrqges sgdmaweevr gvfrvaiqpv
      661 ndhapvqtis rifhvarggr rllttddvaf sdadsgfada qlvltrkdll fgsivavdep
      721 trpiyrftqe dlrkrrvlfv hsgadrgwiq lqvsdgqhqa tallevqase pylrvangss
      781 lvvpqggqgt idtavlhldt nldirsgdev hyhvtagprw gqlvragqpa tafsqqdlld
      841 gavlyshngs lsprdtmafs veagpvhtda tlqvtialeg plaplklvrh kkiyvfqgea
      901 aeirrdqlea aqeavppadi vfsvksppsa gylvmvsrga ladeppsldp vqsfsqeavd
      961 tgrvlylhsr peawsdafsl dvasglgapl egvlvelevl paaipleaqn fsvpeggslt
     1021 lappllrvsg pyfptllgls lqvleppqhg alqkedgpqa rtlsafswrm veeqliryvh
     1081 dgsetltdsf vlmanasemd rqshpvaftv tvlpvndqpp ilttntglqm wegatapipa
     1141 ealrstdgds gsedlvytie qpsngrvvlr gapgtevrsf tqaqldgglv lfshrgtldg
     1201 gfrfrlsdge htspghffrv taqkqvllsl kgsqtltvcp gsvqplssqt lrasssagtd
     1261 pqlllyrvvr gpqlgrlfha qqdstgealv nftqaevyag nilyehempp epfweahdtl
     1321 elqlssppar dvaatlavav sfeaacpqrp shlwknkglw vpegqrarit vaaldasnll
     1381 asvpspqrse hdvlfqvtqf psrgqllvse eplhagqphf lqsqlaagql vyahggggtq
     1441 qdgfhfrahl qgpagasvag pqtseafait vrdvnerppq pqasvplrlt rgsrapisra
     1501 qlsvvdpdsa pgeieyevqr aphngflslv ggglgpvtrf tqadvdsgrl afvangssva
     1561 gifqlsmsdg aspplpmsla vdilpsaiev qlraplevpq algrsslsqq qlrvvsdree
     1621 peaayrliqg pqyghllvgg rptsafsqfq idqgevvfaf tnfssshdhf rvlalargvn
     1681 asavvnvtvr allhvwaggp wpqgatlrld ptvldagela nrtgsvprfr llegprhgrv
     1741 vrvprartep ggsqlveqft qqdledgrlg levgrpegra pgpagdsltl elwaqgvppa
     1801 vasldfatep ynaarpysva llsvpeaart eagkpesstp tgepgpmass pepavakggf
     1861 lsfleanmfs viipmclvll llalilpllf ylrkrnktgk hdvqvltakp rnglagdtet
     1921 frkvepgqai pltavpgqgp ppggqpdpel lqfcrtpnpa lkngqywv
//
LOCUS       XP_016877440             317 aa            linear   PRI 05-AUG-2025
DEFINITION  pro-cathepsin H isoform X1 [Homo sapiens].
ACCESSION   XP_016877440
VERSION     XP_016877440.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021951.2
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 10% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..317
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..317
                     /product="pro-cathepsin H isoform X1"
                     /calculated_mol_wt=35558
     Region          23..72
                     /region_name="Inhibitor_I29"
                     /note="Cathepsin propeptide inhibitor domain (I29);
                     pfam08246"
                     /db_xref="CDD:462410"
     Region          99..314
                     /region_name="Peptidase_C1"
                     /note="Papain family cysteine protease; pfam00112"
                     /db_xref="CDD:425470"
     Site            order(117,123,263,283)
                     /site_type="active"
                     /db_xref="CDD:239068"
     Site            order(167..168,234,261,264,309)
                     /site_type="active"
                     /note="S2 subsite [active]"
                     /db_xref="CDD:239068"
     CDS             1..317
                     /gene="CTSH"
                     /gene_synonym="ACC-4; ACC-5; ACC4; ACC5; CPSB"
                     /coded_by="XM_017021951.2:258..1211"
                     /db_xref="GeneID:1512"
                     /db_xref="HGNC:HGNC:2535"
                     /db_xref="MIM:116820"
ORIGIN      
        1 mvifavnltq hqqwrpgvph mwqhrktyst eeyhhrlqtf asnwrkinah nngnhtfkma
       61 lnqfsdmsfa eikhkylwse pqncsatksn ylrgtgpypp svdwrkkgnf vspvknqgac
      121 gscwtfsttg alesaiaiat gkmlslaeqq lvdcaqdfnn hgcqgglpsq afeyilynkg
      181 imgedtypyq gkdgyckfqp gkaigfvkdv anitiydeea mveavalynp vsfafevtqd
      241 fmmyrtgiys stschktpdk vnhavlavgy gekngipywi vknswgpqwg mngyflierg
      301 knmcglaaca sypiplv
//
LOCUS       XP_006720471             276 aa            linear   PRI 05-AUG-2025
DEFINITION  cilia- and flagella-associated protein 161 isoform X1 [Homo
            sapiens].
ACCESSION   XP_006720471
VERSION     XP_006720471.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720408.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..276
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..276
                     /product="cilia- and flagella-associated protein 161
                     isoform X1"
                     /calculated_mol_wt=31285
     CDS             1..276
                     /gene="CFAP161"
                     /gene_synonym="C15orf26"
                     /coded_by="XM_006720408.3:256..1086"
                     /db_xref="GeneID:161502"
                     /db_xref="HGNC:HGNC:26782"
ORIGIN      
        1 mkdflekrdk gklliqrsrr lkqnllrpmq lsvtedgyih ygdkvmlvnp ddpdteadvf
       61 lrgdlslcmt pdeiqshlkd elevpcglsa vqaktpigrn tfiilsvhrd atgqvlrygq
      121 dfclgitggf dnkmlylssd hrtllksskr swlqevyltd evshvncwqa afpdpqlrle
      181 yegfpvpana kilinhchtn rglaahrhlf lstyfgkeae vvahtyldsh rvekprnhwm
      241 lvtgnprdas ssmldlpkpp tedtrameqa mgldtq
//
LOCUS       XP_016877452             276 aa            linear   PRI 05-AUG-2025
DEFINITION  cilia- and flagella-associated protein 161 isoform X1 [Homo
            sapiens].
ACCESSION   XP_016877452
VERSION     XP_016877452.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021963.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..276
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..276
                     /product="cilia- and flagella-associated protein 161
                     isoform X1"
                     /calculated_mol_wt=31285
     CDS             1..276
                     /gene="CFAP161"
                     /gene_synonym="C15orf26"
                     /coded_by="XM_017021963.2:184..1014"
                     /db_xref="GeneID:161502"
                     /db_xref="HGNC:HGNC:26782"
ORIGIN      
        1 mkdflekrdk gklliqrsrr lkqnllrpmq lsvtedgyih ygdkvmlvnp ddpdteadvf
       61 lrgdlslcmt pdeiqshlkd elevpcglsa vqaktpigrn tfiilsvhrd atgqvlrygq
      121 dfclgitggf dnkmlylssd hrtllksskr swlqevyltd evshvncwqa afpdpqlrle
      181 yegfpvpana kilinhchtn rglaahrhlf lstyfgkeae vvahtyldsh rvekprnhwm
      241 lvtgnprdas ssmldlpkpp tedtrameqa mgldtq
//
LOCUS       XP_006720472             399 aa            linear   PRI 05-AUG-2025
DEFINITION  TBC1 domain family member 21 isoform X1 [Homo sapiens].
ACCESSION   XP_006720472
VERSION     XP_006720472.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720409.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..399
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..399
                     /product="TBC1 domain family member 21 isoform X1"
                     /calculated_mol_wt=45641
     Region          62..287
                     /region_name="TBC"
                     /note="Domain in Tre-2, BUB2p, and Cdc16p. Probable
                     Rab-GAPs; smart00164"
                     /db_xref="CDD:214540"
     CDS             1..399
                     /gene="TBC1D21"
                     /gene_synonym="MgcRabGAP"
                     /coded_by="XM_006720409.5:147..1346"
                     /db_xref="GeneID:161514"
                     /db_xref="HGNC:HGNC:28536"
                     /db_xref="MIM:620387"
ORIGIN      
        1 mttlspensl sarqsasfil vkrkppidkt ewdsffdesg hlaksrdfic vnilerglhp
       61 fvrteawkfl tgyfswqssq derltvdsmr rknykalcqm yekiqpllen lhrnftetrn
      121 niardiqkiy dkdplgnvli dkkrlekill lsyvcntqae yqqgfhemmm lfqlmvehdh
      181 etfwlfqffl qktehscvin igvaknldml stlitfldpv faehlkgkga gavqslfpwf
      241 cfcfqrafks fddvwrlwev lltgkpcrnf qvlvaysmlq mvreqvlqes mggddillac
      301 nnlidldade lisaacvvya eliqkdpmag afnfrdtdca tfsttdpcml llmvfslfah
      361 vapsslsrly ylragpsspi pcvhpsgsgh peaqenvaa
//
LOCUS       XP_006720473             363 aa            linear   PRI 05-AUG-2025
DEFINITION  TBC1 domain family member 21 isoform X2 [Homo sapiens].
ACCESSION   XP_006720473
VERSION     XP_006720473.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720410.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..363
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..363
                     /product="TBC1 domain family member 21 isoform X2"
                     /calculated_mol_wt=41381
     Region          26..251
                     /region_name="TBC"
                     /note="Domain in Tre-2, BUB2p, and Cdc16p. Probable
                     Rab-GAPs; smart00164"
                     /db_xref="CDD:214540"
     CDS             1..363
                     /gene="TBC1D21"
                     /gene_synonym="MgcRabGAP"
                     /coded_by="XM_006720410.5:147..1238"
                     /db_xref="GeneID:161514"
                     /db_xref="HGNC:HGNC:28536"
                     /db_xref="MIM:620387"
ORIGIN      
        1 mttlspensl sarqsasfil glhpfvrtea wkfltgyfsw qssqderltv dsmrrknyka
       61 lcqmyekiqp llenlhrnft etrnniardi qkiydkdplg nvlidkkrle killlsyvcn
      121 tqaeyqqgfh emmmlfqlmv ehdhetfwlf qfflqktehs cvinigvakn ldmlstlitf
      181 ldpvfaehlk gkgagavqsl fpwfcfcfqr afksfddvwr lwevlltgkp crnfqvlvay
      241 smlqmvreqv lqesmggddi llacnnlidl dadelisaac vvyaeliqkd pmagafnfrd
      301 tdcatfsttd pcmlllmvfs lfahvapssl srlyylragp sspipcvhps gsghpeaqen
      361 vaa
//
LOCUS       XP_011519583             361 aa            linear   PRI 05-AUG-2025
DEFINITION  TBC1 domain family member 21 isoform X3 [Homo sapiens].
ACCESSION   XP_011519583
VERSION     XP_011519583.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521281.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..361
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..361
                     /product="TBC1 domain family member 21 isoform X3"
                     /calculated_mol_wt=41732
     Region          62..287
                     /region_name="TBC"
                     /note="Domain in Tre-2, BUB2p, and Cdc16p. Probable
                     Rab-GAPs; smart00164"
                     /db_xref="CDD:214540"
     CDS             1..361
                     /gene="TBC1D21"
                     /gene_synonym="MgcRabGAP"
                     /coded_by="XM_011521281.4:147..1232"
                     /db_xref="GeneID:161514"
                     /db_xref="HGNC:HGNC:28536"
                     /db_xref="MIM:620387"
ORIGIN      
        1 mttlspensl sarqsasfil vkrkppidkt ewdsffdesg hlaksrdfic vnilerglhp
       61 fvrteawkfl tgyfswqssq derltvdsmr rknykalcqm yekiqpllen lhrnftetrn
      121 niardiqkiy dkdplgnvli dkkrlekill lsyvcntqae yqqgfhemmm lfqlmvehdh
      181 etfwlfqffl qktehscvin igvaknldml stlitfldpv faehlkgkga gavqslfpwf
      241 cfcfqrafks fddvwrlwev lltgkpcrnf qvlvaysmlq mvreqvlqes mggddillac
      301 nnlidldade lisaacvvya eliqkdggia lflcrthhsq ggpssgvfrl kdtethfflm
      361 t
//
LOCUS       XP_011519584             337 aa            linear   PRI 05-AUG-2025
DEFINITION  TBC1 domain family member 21 isoform X4 [Homo sapiens].
ACCESSION   XP_011519584
VERSION     XP_011519584.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521282.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..337
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..337
                     /product="TBC1 domain family member 21 isoform X4"
                     /calculated_mol_wt=39271
     Region          62..287
                     /region_name="TBC"
                     /note="Domain in Tre-2, BUB2p, and Cdc16p. Probable
                     Rab-GAPs; smart00164"
                     /db_xref="CDD:214540"
     CDS             1..337
                     /gene="TBC1D21"
                     /gene_synonym="MgcRabGAP"
                     /coded_by="XM_011521282.3:147..1160"
                     /db_xref="GeneID:161514"
                     /db_xref="HGNC:HGNC:28536"
                     /db_xref="MIM:620387"
ORIGIN      
        1 mttlspensl sarqsasfil vkrkppidkt ewdsffdesg hlaksrdfic vnilerglhp
       61 fvrteawkfl tgyfswqssq derltvdsmr rknykalcqm yekiqpllen lhrnftetrn
      121 niardiqkiy dkdplgnvli dkkrlekill lsyvcntqae yqqgfhemmm lfqlmvehdh
      181 etfwlfqffl qktehscvin igvaknldml stlitfldpv faehlkgkga gavqslfpwf
      241 cfcfqrafks fddvwrlwev lltgkpcrnf qvlvaysmlq mvreqvlqes mggddillac
      301 nnlidldade lisaacvvya eliqkdgemw mhcripq
//
LOCUS       XP_011519585             335 aa            linear   PRI 05-AUG-2025
DEFINITION  TBC1 domain family member 21 isoform X5 [Homo sapiens].
ACCESSION   XP_011519585
VERSION     XP_011519585.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521283.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..335
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..335
                     /product="TBC1 domain family member 21 isoform X5"
                     /calculated_mol_wt=38807
     Region          62..287
                     /region_name="TBC"
                     /note="Domain in Tre-2, BUB2p, and Cdc16p. Probable
                     Rab-GAPs; smart00164"
                     /db_xref="CDD:214540"
     CDS             1..335
                     /gene="TBC1D21"
                     /gene_synonym="MgcRabGAP"
                     /coded_by="XM_011521283.3:147..1154"
                     /db_xref="GeneID:161514"
                     /db_xref="HGNC:HGNC:28536"
                     /db_xref="MIM:620387"
ORIGIN      
        1 mttlspensl sarqsasfil vkrkppidkt ewdsffdesg hlaksrdfic vnilerglhp
       61 fvrteawkfl tgyfswqssq derltvdsmr rknykalcqm yekiqpllen lhrnftetrn
      121 niardiqkiy dkdplgnvli dkkrlekill lsyvcntqae yqqgfhemmm lfqlmvehdh
      181 etfwlfqffl qktehscvin igvaknldml stlitfldpv faehlkgkga gavqslfpwf
      241 cfcfqrafks fddvwrlwev lltgkpcrnf qvlvaysmlq mvreqvlqes mggddillac
      301 nnlidldade lisaacvvya eliqkdksat nclst
//
LOCUS       XP_047288154             325 aa            linear   PRI 05-AUG-2025
DEFINITION  TBC1 domain family member 21 isoform X6 [Homo sapiens].
ACCESSION   XP_047288154
VERSION     XP_047288154.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432198.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..325
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..325
                     /product="TBC1 domain family member 21 isoform X6"
                     /calculated_mol_wt=37472
     Region          26..251
                     /region_name="TBC"
                     /note="Domain in Tre-2, BUB2p, and Cdc16p. Probable
                     Rab-GAPs; smart00164"
                     /db_xref="CDD:214540"
     CDS             1..325
                     /gene="TBC1D21"
                     /gene_synonym="MgcRabGAP"
                     /coded_by="XM_047432198.1:147..1124"
                     /db_xref="GeneID:161514"
                     /db_xref="HGNC:HGNC:28536"
                     /db_xref="MIM:620387"
ORIGIN      
        1 mttlspensl sarqsasfil glhpfvrtea wkfltgyfsw qssqderltv dsmrrknyka
       61 lcqmyekiqp llenlhrnft etrnniardi qkiydkdplg nvlidkkrle killlsyvcn
      121 tqaeyqqgfh emmmlfqlmv ehdhetfwlf qfflqktehs cvinigvakn ldmlstlitf
      181 ldpvfaehlk gkgagavqsl fpwfcfcfqr afksfddvwr lwevlltgkp crnfqvlvay
      241 smlqmvreqv lqesmggddi llacnnlidl dadelisaac vvyaeliqkd ggialflcrt
      301 hhsqggpssg vfrlkdteth fflmt
//
LOCUS       XP_011519586             311 aa            linear   PRI 05-AUG-2025
DEFINITION  TBC1 domain family member 21 isoform X7 [Homo sapiens].
ACCESSION   XP_011519586
VERSION     XP_011519586.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521284.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..311
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..311
                     /product="TBC1 domain family member 21 isoform X7"
                     /calculated_mol_wt=35474
     Region          <34..199
                     /region_name="TBC"
                     /note="Domain in Tre-2, BUB2p, and Cdc16p. Probable
                     Rab-GAPs; smart00164"
                     /db_xref="CDD:214540"
     CDS             1..311
                     /gene="TBC1D21"
                     /gene_synonym="MgcRabGAP"
                     /coded_by="XM_011521284.4:202..1137"
                     /db_xref="GeneID:161514"
                     /db_xref="HGNC:HGNC:28536"
                     /db_xref="MIM:620387"
ORIGIN      
        1 mrrknykalc qmyekiqpll enlhrnftet rnniardiqk iydkdplgnv lidkkrleki
       61 lllsyvcntq aeyqqgfhem mmlfqlmveh dhetfwlfqf flqktehscv inigvaknld
      121 mlstlitfld pvfaehlkgk gagavqslfp wfcfcfqraf ksfddvwrlw evlltgkpcr
      181 nfqvlvaysm lqmvreqvlq esmggddill acnnlidlda delisaacvv yaeliqkdpm
      241 agafnfrdtd catfsttdpc mlllmvfslf ahvapsslsr lyylragpss pipcvhpsgs
      301 ghpeaqenva a
//
LOCUS       XP_006720474             300 aa            linear   PRI 05-AUG-2025
DEFINITION  TBC1 domain family member 21 isoform X8 [Homo sapiens].
ACCESSION   XP_006720474
VERSION     XP_006720474.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720411.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..300
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..300
                     /product="TBC1 domain family member 21 isoform X8"
                     /calculated_mol_wt=34082
     Region          <23..188
                     /region_name="TBC"
                     /note="Domain in Tre-2, BUB2p, and Cdc16p. Probable
                     Rab-GAPs; smart00164"
                     /db_xref="CDD:214540"
     CDS             1..300
                     /gene="TBC1D21"
                     /gene_synonym="MgcRabGAP"
                     /coded_by="XM_006720411.4:232..1134"
                     /db_xref="GeneID:161514"
                     /db_xref="HGNC:HGNC:28536"
                     /db_xref="MIM:620387"
ORIGIN      
        1 myekiqplle nlhrnftetr nniardiqki ydkdplgnvl idkkrlekil llsyvcntqa
       61 eyqqgfhemm mlfqlmvehd hetfwlfqff lqktehscvi nigvaknldm lstlitfldp
      121 vfaehlkgkg agavqslfpw fcfcfqrafk sfddvwrlwe vlltgkpcrn fqvlvaysml
      181 qmvreqvlqe smggddilla cnnlidldad elisaacvvy aeliqkdpma gafnfrdtdc
      241 atfsttdpcm lllmvfslfa hvapsslsrl yylragpssp ipcvhpsgsg hpeaqenvaa
//
LOCUS       XP_005254259             456 aa            linear   PRI 05-AUG-2025
DEFINITION  sprouty-related, EVH1 domain-containing protein 1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_005254259
VERSION     XP_005254259.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254202.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..456
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..456
                     /product="sprouty-related, EVH1 domain-containing protein
                     1 isoform X1"
                     /calculated_mol_wt=51720
     Region          25..137
                     /region_name="EVH1_SPRED-like"
                     /note="Sprouty-related EVH1 domain-containing-like
                     proteins EVH1 domain; cd10574"
                     /db_xref="CDD:269978"
     Site            order(34,43,101,103)
                     /site_type="other"
                     /note="putative proline-rich peptide binding site
                     [polypeptide binding]"
                     /db_xref="CDD:269978"
     Region          344..440
                     /region_name="Sprouty"
                     /note="Sprouty protein (Spry); pfam05210"
                     /db_xref="CDD:461589"
     CDS             1..456
                     /gene="SPRED1"
                     /gene_synonym="hSpred1; LGSS; NFLS; PPP1R147; spred-1"
                     /coded_by="XM_005254202.4:351..1721"
                     /db_xref="GeneID:161742"
                     /db_xref="HGNC:HGNC:20249"
                     /db_xref="MIM:609291"
ORIGIN      
        1 mseetatsdn ecqghddgic ffhnsyarvr avvmtrddss ggwlplggsg lssvtvfkvp
       61 hqeengcadf firgerlrdk mvvlecmlkk dliynkvtpt fhhwkiddkk fgltfqspad
      121 arafdrgirr aiedisqgcp eskneaegad dlqaneedss sslvkdhlfq qetvvtsepy
      181 rssnirpspf edlnarrvym qsqanqitfg qpgldiqsrs meyvqrqisk ecgslksqnr
      241 vplksirhvs fqdedeivri nprdilirry adyrhpdmwk ndlerddads siqfskpdsk
      301 ksdylyscgd etklsspkds vvfktqpssl kikkskrrke dgersrcvyc qerfnheenv
      361 rgkcqdapdp ikrciyqvsc mlcaesmlyh cmsdsegdfs dpcscdtsdd kfclrwlalv
      421 alsfivpcmc cyvplrmchr cgeacgccgg khkaag
//
LOCUS       XP_047288155             423 aa            linear   PRI 05-AUG-2025
DEFINITION  sprouty-related, EVH1 domain-containing protein 1 isoform X2 [Homo
            sapiens].
ACCESSION   XP_047288155
VERSION     XP_047288155.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432199.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..423
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..423
                     /product="sprouty-related, EVH1 domain-containing protein
                     1 isoform X2"
                     /calculated_mol_wt=48048
     Region          1..104
                     /region_name="EVH1_SPRED-like"
                     /note="Sprouty-related EVH1 domain-containing-like
                     proteins EVH1 domain; cd10574"
                     /db_xref="CDD:269978"
     Site            order(1,10,68,70)
                     /site_type="other"
                     /note="putative proline-rich peptide binding site
                     [polypeptide binding]"
                     /db_xref="CDD:269978"
     Region          311..407
                     /region_name="Sprouty"
                     /note="Sprouty protein (Spry); pfam05210"
                     /db_xref="CDD:461589"
     CDS             1..423
                     /gene="SPRED1"
                     /gene_synonym="hSpred1; LGSS; NFLS; PPP1R147; spred-1"
                     /coded_by="XM_047432199.1:514..1785"
                     /db_xref="GeneID:161742"
                     /db_xref="HGNC:HGNC:20249"
                     /db_xref="MIM:609291"
ORIGIN      
        1 mtrddssggw lplggsglss vtvfkvphqe engcadffir gerlrdkmvv lecmlkkdli
       61 ynkvtptfhh wkiddkkfgl tfqspadara fdrgirraie disqgcpesk neaegaddlq
      121 aneedssssl vkdhlfqqet vvtsepyrss nirpspfedl narrvymqsq anqitfgqpg
      181 ldiqsrsmey vqrqiskecg slksqnrvpl ksirhvsfqd edeivrinpr dilirryady
      241 rhpdmwkndl erddadssiq fskpdskksd ylyscgdetk lsspkdsvvf ktqpsslkik
      301 kskrrkedge rsrcvycqer fnheenvrgk cqdapdpikr ciyqvscmlc aesmlyhcms
      361 dsegdfsdpc scdtsddkfc lrwlalvals fivpcmccyv plrmchrcge acgccggkhk
      421 aag
//
LOCUS       XP_047288156             423 aa            linear   PRI 05-AUG-2025
DEFINITION  sprouty-related, EVH1 domain-containing protein 1 isoform X2 [Homo
            sapiens].
ACCESSION   XP_047288156
VERSION     XP_047288156.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432200.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..423
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..423
                     /product="sprouty-related, EVH1 domain-containing protein
                     1 isoform X2"
                     /calculated_mol_wt=48048
     Region          1..104
                     /region_name="EVH1_SPRED-like"
                     /note="Sprouty-related EVH1 domain-containing-like
                     proteins EVH1 domain; cd10574"
                     /db_xref="CDD:269978"
     Site            order(1,10,68,70)
                     /site_type="other"
                     /note="putative proline-rich peptide binding site
                     [polypeptide binding]"
                     /db_xref="CDD:269978"
     Region          311..407
                     /region_name="Sprouty"
                     /note="Sprouty protein (Spry); pfam05210"
                     /db_xref="CDD:461589"
     CDS             1..423
                     /gene="SPRED1"
                     /gene_synonym="hSpred1; LGSS; NFLS; PPP1R147; spred-1"
                     /coded_by="XM_047432200.1:478..1749"
                     /db_xref="GeneID:161742"
                     /db_xref="HGNC:HGNC:20249"
                     /db_xref="MIM:609291"
ORIGIN      
        1 mtrddssggw lplggsglss vtvfkvphqe engcadffir gerlrdkmvv lecmlkkdli
       61 ynkvtptfhh wkiddkkfgl tfqspadara fdrgirraie disqgcpesk neaegaddlq
      121 aneedssssl vkdhlfqqet vvtsepyrss nirpspfedl narrvymqsq anqitfgqpg
      181 ldiqsrsmey vqrqiskecg slksqnrvpl ksirhvsfqd edeivrinpr dilirryady
      241 rhpdmwkndl erddadssiq fskpdskksd ylyscgdetk lsspkdsvvf ktqpsslkik
      301 kskrrkedge rsrcvycqer fnheenvrgk cqdapdpikr ciyqvscmlc aesmlyhcms
      361 dsegdfsdpc scdtsddkfc lrwlalvals fivpcmccyv plrmchrcge acgccggkhk
      421 aag
//
LOCUS       XP_047288157             423 aa            linear   PRI 05-AUG-2025
DEFINITION  sprouty-related, EVH1 domain-containing protein 1 isoform X2 [Homo
            sapiens].
ACCESSION   XP_047288157
VERSION     XP_047288157.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432201.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..423
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..423
                     /product="sprouty-related, EVH1 domain-containing protein
                     1 isoform X2"
                     /calculated_mol_wt=48048
     Region          1..104
                     /region_name="EVH1_SPRED-like"
                     /note="Sprouty-related EVH1 domain-containing-like
                     proteins EVH1 domain; cd10574"
                     /db_xref="CDD:269978"
     Site            order(1,10,68,70)
                     /site_type="other"
                     /note="putative proline-rich peptide binding site
                     [polypeptide binding]"
                     /db_xref="CDD:269978"
     Region          311..407
                     /region_name="Sprouty"
                     /note="Sprouty protein (Spry); pfam05210"
                     /db_xref="CDD:461589"
     CDS             1..423
                     /gene="SPRED1"
                     /gene_synonym="hSpred1; LGSS; NFLS; PPP1R147; spred-1"
                     /coded_by="XM_047432201.1:151..1422"
                     /db_xref="GeneID:161742"
                     /db_xref="HGNC:HGNC:20249"
                     /db_xref="MIM:609291"
ORIGIN      
        1 mtrddssggw lplggsglss vtvfkvphqe engcadffir gerlrdkmvv lecmlkkdli
       61 ynkvtptfhh wkiddkkfgl tfqspadara fdrgirraie disqgcpesk neaegaddlq
      121 aneedssssl vkdhlfqqet vvtsepyrss nirpspfedl narrvymqsq anqitfgqpg
      181 ldiqsrsmey vqrqiskecg slksqnrvpl ksirhvsfqd edeivrinpr dilirryady
      241 rhpdmwkndl erddadssiq fskpdskksd ylyscgdetk lsspkdsvvf ktqpsslkik
      301 kskrrkedge rsrcvycqer fnheenvrgk cqdapdpikr ciyqvscmlc aesmlyhcms
      361 dsegdfsdpc scdtsddkfc lrwlalvals fivpcmccyv plrmchrcge acgccggkhk
      421 aag
//
LOCUS       XP_006720477             291 aa            linear   PRI 05-AUG-2025
DEFINITION  protein CIMAP1C isoform X1 [Homo sapiens].
ACCESSION   XP_006720477
VERSION     XP_006720477.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720414.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..291
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..291
                     /product="protein CIMAP1C isoform X1"
                     /calculated_mol_wt=32546
     CDS             1..291
                     /gene="CIMAP1C"
                     /gene_synonym="ODF3L1"
                     /coded_by="XM_006720414.4:160..1035"
                     /db_xref="GeneID:161753"
                     /db_xref="HGNC:HGNC:28735"
ORIGIN      
        1 mklpkgtrss vyfaqhpeke plpsrqevkq tpvimakikg pgpakylrps ctgyidhdis
       61 mfkapaytlh srhsekrerc hpshpagvga vvggmvchss pgpcylldpk itrfgmsscp
      121 qvpmeerisn lrlnptlasc qyyfekihpp gerrapqytf gyrrpyrvmd lnpapnqyqm
      181 plllgpntpv sraapcysla srdknwfyke dvaggpgptt yarpepsiyq nrsptysmak
      241 rfaypldltp rpgpgshevq qvtvhkphip aftmgikhsl hlcplvidir d
//
LOCUS       XP_011519593             355 aa            linear   PRI 05-AUG-2025
DEFINITION  N6-Methyl-AMP deaminase isoform X1 [Homo sapiens].
ACCESSION   XP_011519593
VERSION     XP_011519593.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521291.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..355
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..355
                     /product="N6-Methyl-AMP deaminase isoform X1"
                     /calculated_mol_wt=40133
     Region          18..345
                     /region_name="ADA_AMPD"
                     /note="Adenosine/AMP deaminase. Adenosine deaminases
                     (ADAs) are present in pro- and eukaryotic organisms and
                     catalyze the zinc dependent irreversible deamination of
                     adenosine nucleosides to inosine nucleosides and ammonia.
                     The eukaryotic AMP deaminase...; cd00443"
                     /db_xref="CDD:238250"
     Site            order(24,26,208,211,232,293..294)
                     /site_type="active"
                     /db_xref="CDD:238250"
     CDS             1..355
                     /gene="MAPDA"
                     /gene_synonym="ADAL; HsMAPDA"
                     /coded_by="XM_011521291.3:453..1520"
                     /db_xref="GeneID:161823"
                     /db_xref="HGNC:HGNC:31853"
                     /db_xref="MIM:619346"
ORIGIN      
        1 mieaeeqqpc ktdfyselpk velhahlngs isshtmkkli aqkpdlkihd qmtvidkgkk
       61 rtleecfqmf qtihqltssp edilmvtkdv ikefaddgvk ylelrstprr enatgmtkkt
      121 yvesilegik qskqenldid vryliavdrr ggplvaketv klaeefflst egtvlgldls
      181 gdptvgqakd fleplleakk aglklalhls eipnqkketq illdllpdri ghgtflnsge
      241 ggsldlvdfv rqhriplelc ltsnvksqtv psydqhhfgf wysiahpsvi ctddkgvfat
      301 hlsqeyqlaa etfnltqsqv wdlsyesiny ifasdstrse lrkkwnhlkp rvlhi
//
LOCUS       XP_016877453             355 aa            linear   PRI 05-AUG-2025
DEFINITION  N6-Methyl-AMP deaminase isoform X1 [Homo sapiens].
ACCESSION   XP_016877453
VERSION     XP_016877453.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021964.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..355
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..355
                     /product="N6-Methyl-AMP deaminase isoform X1"
                     /calculated_mol_wt=40133
     Region          18..345
                     /region_name="ADA_AMPD"
                     /note="Adenosine/AMP deaminase. Adenosine deaminases
                     (ADAs) are present in pro- and eukaryotic organisms and
                     catalyze the zinc dependent irreversible deamination of
                     adenosine nucleosides to inosine nucleosides and ammonia.
                     The eukaryotic AMP deaminase...; cd00443"
                     /db_xref="CDD:238250"
     Site            order(24,26,208,211,232,293..294)
                     /site_type="active"
                     /db_xref="CDD:238250"
     CDS             1..355
                     /gene="MAPDA"
                     /gene_synonym="ADAL; HsMAPDA"
                     /coded_by="XM_017021964.3:436..1503"
                     /db_xref="GeneID:161823"
                     /db_xref="HGNC:HGNC:31853"
                     /db_xref="MIM:619346"
ORIGIN      
        1 mieaeeqqpc ktdfyselpk velhahlngs isshtmkkli aqkpdlkihd qmtvidkgkk
       61 rtleecfqmf qtihqltssp edilmvtkdv ikefaddgvk ylelrstprr enatgmtkkt
      121 yvesilegik qskqenldid vryliavdrr ggplvaketv klaeefflst egtvlgldls
      181 gdptvgqakd fleplleakk aglklalhls eipnqkketq illdllpdri ghgtflnsge
      241 ggsldlvdfv rqhriplelc ltsnvksqtv psydqhhfgf wysiahpsvi ctddkgvfat
      301 hlsqeyqlaa etfnltqsqv wdlsyesiny ifasdstrse lrkkwnhlkp rvlhi
//
LOCUS       XP_016877454             355 aa            linear   PRI 05-AUG-2025
DEFINITION  N6-Methyl-AMP deaminase isoform X1 [Homo sapiens].
ACCESSION   XP_016877454
VERSION     XP_016877454.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021965.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..355
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..355
                     /product="N6-Methyl-AMP deaminase isoform X1"
                     /calculated_mol_wt=40133
     Region          18..345
                     /region_name="ADA_AMPD"
                     /note="Adenosine/AMP deaminase. Adenosine deaminases
                     (ADAs) are present in pro- and eukaryotic organisms and
                     catalyze the zinc dependent irreversible deamination of
                     adenosine nucleosides to inosine nucleosides and ammonia.
                     The eukaryotic AMP deaminase...; cd00443"
                     /db_xref="CDD:238250"
     Site            order(24,26,208,211,232,293..294)
                     /site_type="active"
                     /db_xref="CDD:238250"
     CDS             1..355
                     /gene="MAPDA"
                     /gene_synonym="ADAL; HsMAPDA"
                     /coded_by="XM_017021965.2:606..1673"
                     /db_xref="GeneID:161823"
                     /db_xref="HGNC:HGNC:31853"
                     /db_xref="MIM:619346"
ORIGIN      
        1 mieaeeqqpc ktdfyselpk velhahlngs isshtmkkli aqkpdlkihd qmtvidkgkk
       61 rtleecfqmf qtihqltssp edilmvtkdv ikefaddgvk ylelrstprr enatgmtkkt
      121 yvesilegik qskqenldid vryliavdrr ggplvaketv klaeefflst egtvlgldls
      181 gdptvgqakd fleplleakk aglklalhls eipnqkketq illdllpdri ghgtflnsge
      241 ggsldlvdfv rqhriplelc ltsnvksqtv psydqhhfgf wysiahpsvi ctddkgvfat
      301 hlsqeyqlaa etfnltqsqv wdlsyesiny ifasdstrse lrkkwnhlkp rvlhi
//
LOCUS       XP_016877455             355 aa            linear   PRI 05-AUG-2025
DEFINITION  N6-Methyl-AMP deaminase isoform X1 [Homo sapiens].
ACCESSION   XP_016877455
VERSION     XP_016877455.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021966.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..355
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..355
                     /product="N6-Methyl-AMP deaminase isoform X1"
                     /calculated_mol_wt=40133
     Region          18..345
                     /region_name="ADA_AMPD"
                     /note="Adenosine/AMP deaminase. Adenosine deaminases
                     (ADAs) are present in pro- and eukaryotic organisms and
                     catalyze the zinc dependent irreversible deamination of
                     adenosine nucleosides to inosine nucleosides and ammonia.
                     The eukaryotic AMP deaminase...; cd00443"
                     /db_xref="CDD:238250"
     Site            order(24,26,208,211,232,293..294)
                     /site_type="active"
                     /db_xref="CDD:238250"
     CDS             1..355
                     /gene="MAPDA"
                     /gene_synonym="ADAL; HsMAPDA"
                     /coded_by="XM_017021966.3:476..1543"
                     /db_xref="GeneID:161823"
                     /db_xref="HGNC:HGNC:31853"
                     /db_xref="MIM:619346"
ORIGIN      
        1 mieaeeqqpc ktdfyselpk velhahlngs isshtmkkli aqkpdlkihd qmtvidkgkk
       61 rtleecfqmf qtihqltssp edilmvtkdv ikefaddgvk ylelrstprr enatgmtkkt
      121 yvesilegik qskqenldid vryliavdrr ggplvaketv klaeefflst egtvlgldls
      181 gdptvgqakd fleplleakk aglklalhls eipnqkketq illdllpdri ghgtflnsge
      241 ggsldlvdfv rqhriplelc ltsnvksqtv psydqhhfgf wysiahpsvi ctddkgvfat
      301 hlsqeyqlaa etfnltqsqv wdlsyesiny ifasdstrse lrkkwnhlkp rvlhi
//
LOCUS       XP_024305626             328 aa            linear   PRI 05-AUG-2025
DEFINITION  N6-Methyl-AMP deaminase isoform X2 [Homo sapiens].
ACCESSION   XP_024305626
VERSION     XP_024305626.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449858.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..328
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..328
                     /product="N6-Methyl-AMP deaminase isoform X2"
                     /calculated_mol_wt=37231
     Region          18..318
                     /region_name="ADA_AMPD"
                     /note="Adenosine/AMP deaminase. Adenosine deaminases
                     (ADAs) are present in pro- and eukaryotic organisms and
                     catalyze the zinc dependent irreversible deamination of
                     adenosine nucleosides to inosine nucleosides and ammonia.
                     The eukaryotic AMP deaminase...; cd00443"
                     /db_xref="CDD:238250"
     CDS             1..328
                     /gene="MAPDA"
                     /gene_synonym="ADAL; HsMAPDA"
                     /coded_by="XM_024449858.2:453..1439"
                     /db_xref="GeneID:161823"
                     /db_xref="HGNC:HGNC:31853"
                     /db_xref="MIM:619346"
ORIGIN      
        1 mieaeeqqpc ktdfyselpk velhahlngs isshtmkkli aqkpdlkihd qmtvidkgkk
       61 rtleecfqmf qtihqltssp edilmvtkdv ikefaddgvk ylelrstprr enatgmtkkt
      121 yvesilegik qskqenldid vryliavdrr ggplvaketv klaeefflst egtvlgldls
      181 gdptipnqkk etqilldllp drighgtfln sgeggsldlv dfvrqhripl elcltsnvks
      241 qtvpsydqhh fgfwysiahp svictddkgv fathlsqeyq laaetfnltq sqvwdlsyes
      301 inyifasdst rselrkkwnh lkprvlhi
//
LOCUS       XP_047288158             328 aa            linear   PRI 05-AUG-2025
DEFINITION  N6-Methyl-AMP deaminase isoform X2 [Homo sapiens].
ACCESSION   XP_047288158
VERSION     XP_047288158.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432202.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..328
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..328
                     /product="N6-Methyl-AMP deaminase isoform X2"
                     /calculated_mol_wt=37231
     Region          18..318
                     /region_name="ADA_AMPD"
                     /note="Adenosine/AMP deaminase. Adenosine deaminases
                     (ADAs) are present in pro- and eukaryotic organisms and
                     catalyze the zinc dependent irreversible deamination of
                     adenosine nucleosides to inosine nucleosides and ammonia.
                     The eukaryotic AMP deaminase...; cd00443"
                     /db_xref="CDD:238250"
     CDS             1..328
                     /gene="MAPDA"
                     /gene_synonym="ADAL; HsMAPDA"
                     /coded_by="XM_047432202.1:436..1422"
                     /db_xref="GeneID:161823"
                     /db_xref="HGNC:HGNC:31853"
                     /db_xref="MIM:619346"
ORIGIN      
        1 mieaeeqqpc ktdfyselpk velhahlngs isshtmkkli aqkpdlkihd qmtvidkgkk
       61 rtleecfqmf qtihqltssp edilmvtkdv ikefaddgvk ylelrstprr enatgmtkkt
      121 yvesilegik qskqenldid vryliavdrr ggplvaketv klaeefflst egtvlgldls
      181 gdptipnqkk etqilldllp drighgtfln sgeggsldlv dfvrqhripl elcltsnvks
      241 qtvpsydqhh fgfwysiahp svictddkgv fathlsqeyq laaetfnltq sqvwdlsyes
      301 inyifasdst rselrkkwnh lkprvlhi
//
LOCUS       XP_047288159             328 aa            linear   PRI 05-AUG-2025
DEFINITION  N6-Methyl-AMP deaminase isoform X2 [Homo sapiens].
ACCESSION   XP_047288159
VERSION     XP_047288159.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432203.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..328
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..328
                     /product="N6-Methyl-AMP deaminase isoform X2"
                     /calculated_mol_wt=37231
     Region          18..318
                     /region_name="ADA_AMPD"
                     /note="Adenosine/AMP deaminase. Adenosine deaminases
                     (ADAs) are present in pro- and eukaryotic organisms and
                     catalyze the zinc dependent irreversible deamination of
                     adenosine nucleosides to inosine nucleosides and ammonia.
                     The eukaryotic AMP deaminase...; cd00443"
                     /db_xref="CDD:238250"
     CDS             1..328
                     /gene="MAPDA"
                     /gene_synonym="ADAL; HsMAPDA"
                     /coded_by="XM_047432203.1:606..1592"
                     /db_xref="GeneID:161823"
                     /db_xref="HGNC:HGNC:31853"
                     /db_xref="MIM:619346"
ORIGIN      
        1 mieaeeqqpc ktdfyselpk velhahlngs isshtmkkli aqkpdlkihd qmtvidkgkk
       61 rtleecfqmf qtihqltssp edilmvtkdv ikefaddgvk ylelrstprr enatgmtkkt
      121 yvesilegik qskqenldid vryliavdrr ggplvaketv klaeefflst egtvlgldls
      181 gdptipnqkk etqilldllp drighgtfln sgeggsldlv dfvrqhripl elcltsnvks
      241 qtvpsydqhh fgfwysiahp svictddkgv fathlsqeyq laaetfnltq sqvwdlsyes
      301 inyifasdst rselrkkwnh lkprvlhi
//
LOCUS       XP_047288160             328 aa            linear   PRI 05-AUG-2025
DEFINITION  N6-Methyl-AMP deaminase isoform X2 [Homo sapiens].
ACCESSION   XP_047288160
VERSION     XP_047288160.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432204.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..328
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..328
                     /product="N6-Methyl-AMP deaminase isoform X2"
                     /calculated_mol_wt=37231
     Region          18..318
                     /region_name="ADA_AMPD"
                     /note="Adenosine/AMP deaminase. Adenosine deaminases
                     (ADAs) are present in pro- and eukaryotic organisms and
                     catalyze the zinc dependent irreversible deamination of
                     adenosine nucleosides to inosine nucleosides and ammonia.
                     The eukaryotic AMP deaminase...; cd00443"
                     /db_xref="CDD:238250"
     CDS             1..328
                     /gene="MAPDA"
                     /gene_synonym="ADAL; HsMAPDA"
                     /coded_by="XM_047432204.1:476..1462"
                     /db_xref="GeneID:161823"
                     /db_xref="HGNC:HGNC:31853"
                     /db_xref="MIM:619346"
ORIGIN      
        1 mieaeeqqpc ktdfyselpk velhahlngs isshtmkkli aqkpdlkihd qmtvidkgkk
       61 rtleecfqmf qtihqltssp edilmvtkdv ikefaddgvk ylelrstprr enatgmtkkt
      121 yvesilegik qskqenldid vryliavdrr ggplvaketv klaeefflst egtvlgldls
      181 gdptipnqkk etqilldllp drighgtfln sgeggsldlv dfvrqhripl elcltsnvks
      241 qtvpsydqhh fgfwysiahp svictddkgv fathlsqeyq laaetfnltq sqvwdlsyes
      301 inyifasdst rselrkkwnh lkprvlhi
//
LOCUS       XP_016877456             320 aa            linear   PRI 05-AUG-2025
DEFINITION  N6-Methyl-AMP deaminase isoform X3 [Homo sapiens].
ACCESSION   XP_016877456
VERSION     XP_016877456.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021967.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..320
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..320
                     /product="N6-Methyl-AMP deaminase isoform X3"
                     /calculated_mol_wt=36181
     Region          29..310
                     /region_name="ADA_AMPD"
                     /note="Adenosine/AMP deaminase. Adenosine deaminases
                     (ADAs) are present in pro- and eukaryotic organisms and
                     catalyze the zinc dependent irreversible deamination of
                     adenosine nucleosides to inosine nucleosides and ammonia.
                     The eukaryotic AMP deaminase...; cd00443"
                     /db_xref="CDD:238250"
     CDS             1..320
                     /gene="MAPDA"
                     /gene_synonym="ADAL; HsMAPDA"
                     /coded_by="XM_017021967.2:332..1294"
                     /db_xref="GeneID:161823"
                     /db_xref="HGNC:HGNC:31853"
                     /db_xref="MIM:619346"
ORIGIN      
        1 mkkliaqkpd lkihdqmtvi dkgkkrtlee cfqmfqtihq ltsspedilm vtkdvikefa
       61 ddgvkylelr stprrenatg mtkktyvesi legikqskqe nldidvryli avdrrggplv
      121 aketvklaee fflstegtvl gldlsgdptv gqakdflepl leakkaglkl alhlseipnq
      181 kketqilldl lpdrighgtf lnsgeggsld lvdfvrqhri plelcltsnv ksqtvpsydq
      241 hhfgfwysia hpsvictddk gvfathlsqe yqlaaetfnl tqsqvwdlsy esinyifasd
      301 strselrkkw nhlkprvlhi
//
LOCUS       XP_016877457             258 aa            linear   PRI 05-AUG-2025
DEFINITION  N6-Methyl-AMP deaminase isoform X4 [Homo sapiens].
ACCESSION   XP_016877457
VERSION     XP_016877457.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021968.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..258
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..258
                     /product="N6-Methyl-AMP deaminase isoform X4"
                     /calculated_mol_wt=28860
     Region          18..>257
                     /region_name="metallo-dependent_hydrolases"
                     /note="Superfamily of metallo-dependent hydrolases (also
                     called amidohydrolase superfamily) is a large group of
                     proteins that show conservation in their 3-dimensional
                     fold (TIM barrel) and in details of their active site. The
                     vast majority of the members have a...; cl00281"
                     /db_xref="CDD:469705"
     Site            order(24,26,208,232)
                     /site_type="active"
                     /db_xref="CDD:238250"
     CDS             1..258
                     /gene="MAPDA"
                     /gene_synonym="ADAL; HsMAPDA"
                     /coded_by="XM_017021968.2:577..1353"
                     /db_xref="GeneID:161823"
                     /db_xref="HGNC:HGNC:31853"
                     /db_xref="MIM:619346"
ORIGIN      
        1 mieaeeqqpc ktdfyselpk velhahlngs isshtmkkli aqkpdlkihd qmtvidkgkk
       61 rtleecfqmf qtihqltssp edilmvtkdv ikefaddgvk ylelrstprr enatgmtkkt
      121 yvesilegik qskqenldid vryliavdrr ggplvaketv klaeefflst egtvlgldls
      181 gdptvgqakd fleplleakk aglklalhls eipnqkketq illdllpdri ghgtflnsge
      241 ggsldlvdfv rqhripld
//
LOCUS       XP_047288161             258 aa            linear   PRI 05-AUG-2025
DEFINITION  N6-Methyl-AMP deaminase isoform X4 [Homo sapiens].
ACCESSION   XP_047288161
VERSION     XP_047288161.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432205.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..258
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..258
                     /product="N6-Methyl-AMP deaminase isoform X4"
                     /calculated_mol_wt=28860
     Region          18..>257
                     /region_name="metallo-dependent_hydrolases"
                     /note="Superfamily of metallo-dependent hydrolases (also
                     called amidohydrolase superfamily) is a large group of
                     proteins that show conservation in their 3-dimensional
                     fold (TIM barrel) and in details of their active site. The
                     vast majority of the members have a...; cl00281"
                     /db_xref="CDD:469705"
     Site            order(24,26,208,232)
                     /site_type="active"
                     /db_xref="CDD:238250"
     CDS             1..258
                     /gene="MAPDA"
                     /gene_synonym="ADAL; HsMAPDA"
                     /coded_by="XM_047432205.1:453..1229"
                     /db_xref="GeneID:161823"
                     /db_xref="HGNC:HGNC:31853"
                     /db_xref="MIM:619346"
ORIGIN      
        1 mieaeeqqpc ktdfyselpk velhahlngs isshtmkkli aqkpdlkihd qmtvidkgkk
       61 rtleecfqmf qtihqltssp edilmvtkdv ikefaddgvk ylelrstprr enatgmtkkt
      121 yvesilegik qskqenldid vryliavdrr ggplvaketv klaeefflst egtvlgldls
      181 gdptvgqakd fleplleakk aglklalhls eipnqkketq illdllpdri ghgtflnsge
      241 ggsldlvdfv rqhripld
//
LOCUS       XP_047288162             258 aa            linear   PRI 05-AUG-2025
DEFINITION  N6-Methyl-AMP deaminase isoform X4 [Homo sapiens].
ACCESSION   XP_047288162
VERSION     XP_047288162.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432206.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..258
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..258
                     /product="N6-Methyl-AMP deaminase isoform X4"
                     /calculated_mol_wt=28860
     Region          18..>257
                     /region_name="metallo-dependent_hydrolases"
                     /note="Superfamily of metallo-dependent hydrolases (also
                     called amidohydrolase superfamily) is a large group of
                     proteins that show conservation in their 3-dimensional
                     fold (TIM barrel) and in details of their active site. The
                     vast majority of the members have a...; cl00281"
                     /db_xref="CDD:469705"
     Site            order(24,26,208,232)
                     /site_type="active"
                     /db_xref="CDD:238250"
     CDS             1..258
                     /gene="MAPDA"
                     /gene_synonym="ADAL; HsMAPDA"
                     /coded_by="XM_047432206.1:436..1212"
                     /db_xref="GeneID:161823"
                     /db_xref="HGNC:HGNC:31853"
                     /db_xref="MIM:619346"
ORIGIN      
        1 mieaeeqqpc ktdfyselpk velhahlngs isshtmkkli aqkpdlkihd qmtvidkgkk
       61 rtleecfqmf qtihqltssp edilmvtkdv ikefaddgvk ylelrstprr enatgmtkkt
      121 yvesilegik qskqenldid vryliavdrr ggplvaketv klaeefflst egtvlgldls
      181 gdptvgqakd fleplleakk aglklalhls eipnqkketq illdllpdri ghgtflnsge
      241 ggsldlvdfv rqhripld
//
LOCUS       XP_047288163             258 aa            linear   PRI 05-AUG-2025
DEFINITION  N6-Methyl-AMP deaminase isoform X4 [Homo sapiens].
ACCESSION   XP_047288163
VERSION     XP_047288163.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432207.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..258
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..258
                     /product="N6-Methyl-AMP deaminase isoform X4"
                     /calculated_mol_wt=28860
     Region          18..>257
                     /region_name="metallo-dependent_hydrolases"
                     /note="Superfamily of metallo-dependent hydrolases (also
                     called amidohydrolase superfamily) is a large group of
                     proteins that show conservation in their 3-dimensional
                     fold (TIM barrel) and in details of their active site. The
                     vast majority of the members have a...; cl00281"
                     /db_xref="CDD:469705"
     Site            order(24,26,208,232)
                     /site_type="active"
                     /db_xref="CDD:238250"
     CDS             1..258
                     /gene="MAPDA"
                     /gene_synonym="ADAL; HsMAPDA"
                     /coded_by="XM_047432207.1:606..1382"
                     /db_xref="GeneID:161823"
                     /db_xref="HGNC:HGNC:31853"
                     /db_xref="MIM:619346"
ORIGIN      
        1 mieaeeqqpc ktdfyselpk velhahlngs isshtmkkli aqkpdlkihd qmtvidkgkk
       61 rtleecfqmf qtihqltssp edilmvtkdv ikefaddgvk ylelrstprr enatgmtkkt
      121 yvesilegik qskqenldid vryliavdrr ggplvaketv klaeefflst egtvlgldls
      181 gdptvgqakd fleplleakk aglklalhls eipnqkketq illdllpdri ghgtflnsge
      241 ggsldlvdfv rqhripld
//
LOCUS       XP_047288164             231 aa            linear   PRI 05-AUG-2025
DEFINITION  N6-Methyl-AMP deaminase isoform X5 [Homo sapiens].
ACCESSION   XP_047288164
VERSION     XP_047288164.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432208.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..231
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..231
                     /product="N6-Methyl-AMP deaminase isoform X5"
                     /calculated_mol_wt=25959
     Region          18..>230
                     /region_name="metallo-dependent_hydrolases"
                     /note="Superfamily of metallo-dependent hydrolases (also
                     called amidohydrolase superfamily) is a large group of
                     proteins that show conservation in their 3-dimensional
                     fold (TIM barrel) and in details of their active site. The
                     vast majority of the members have a...; cl00281"
                     /db_xref="CDD:469705"
     CDS             1..231
                     /gene="MAPDA"
                     /gene_synonym="ADAL; HsMAPDA"
                     /coded_by="XM_047432208.1:577..1272"
                     /db_xref="GeneID:161823"
                     /db_xref="HGNC:HGNC:31853"
                     /db_xref="MIM:619346"
ORIGIN      
        1 mieaeeqqpc ktdfyselpk velhahlngs isshtmkkli aqkpdlkihd qmtvidkgkk
       61 rtleecfqmf qtihqltssp edilmvtkdv ikefaddgvk ylelrstprr enatgmtkkt
      121 yvesilegik qskqenldid vryliavdrr ggplvaketv klaeefflst egtvlgldls
      181 gdptipnqkk etqilldllp drighgtfln sgeggsldlv dfvrqhripl d
//
LOCUS       XP_011519600             572 aa            linear   PRI 05-AUG-2025
DEFINITION  piRNA biogenesis protein EXD1 isoform X1 [Homo sapiens].
ACCESSION   XP_011519600
VERSION     XP_011519600.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521298.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..572
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..572
                     /product="piRNA biogenesis protein EXD1 isoform X1"
                     /calculated_mol_wt=64691
     Region          147..345
                     /region_name="Egl_like_exo"
                     /note="DEDDy 3'-5' exonuclease domain of Drosophila
                     Egalitarian (Egl) and similar proteins; cd06148"
                     /db_xref="CDD:99851"
     Site            order(162..165,216..217,219..221,261..262,306,310)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:99851"
     Site            order(162,164,221,306,310)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:99851"
     Site            order(163..165,216..217,219..220,261..262,306,310)
                     /site_type="other"
                     /note="putative substrate binding site [chemical binding]"
                     /db_xref="CDD:99851"
     CDS             1..572
                     /gene="EXD1"
                     /gene_synonym="EXDL1"
                     /coded_by="XM_011521298.3:246..1964"
                     /db_xref="GeneID:161829"
                     /db_xref="HGNC:HGNC:28507"
ORIGIN      
        1 mdpssdyhfl sqilwkrvkl tlvcgvfegv lqhvdpnkiv vlkkvknvet grsvpgvklf
       61 fgheivnvel ldeveqgsvr akassvslha ertwmekmkv edlnvcepas papeapatsl
      121 lndlkyspse eeevtytvin qfqqkfgaai lhikkqnvls vaaeganvcr hgklcwlqva
      181 tncrvylfdi fllgsrafhn glqmiledkr ilkvihdcrw lsdclshqyg illnnvfdtq
      241 vadvlqfsme tggylpncit tlqeslikhl qvapkylsfl ekrqkliqen pevwfirpvs
      301 psllkilale atyllplrla lldemmsdlt tlvdgylnty regsadrlgg teptcmelpe
      361 ellqlkdfqk qrrekaarey rvnaqgllir tvlqpkklvt etagkeekvk gflfgknfri
      421 dkapsftsqd fhgdvnllke eslnkqatnp qhlppteege tsedssnkli ctkskgsedq
      481 ritqkehfmt pkhefqasls lkeeteqllm venkedlkct kqavsmssfp qetrvspsdt
      541 fypirktvvs tlppcpalek idswispfln lp
//
LOCUS       XP_047288165             518 aa            linear   PRI 05-AUG-2025
DEFINITION  piRNA biogenesis protein EXD1 isoform X2 [Homo sapiens].
ACCESSION   XP_047288165
VERSION     XP_047288165.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432209.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..518
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..518
                     /product="piRNA biogenesis protein EXD1 isoform X2"
                     /calculated_mol_wt=58763
     Region          93..291
                     /region_name="Egl_like_exo"
                     /note="DEDDy 3'-5' exonuclease domain of Drosophila
                     Egalitarian (Egl) and similar proteins; cd06148"
                     /db_xref="CDD:99851"
     Site            order(108..111,162..163,165..167,207..208,252,256)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:99851"
     Site            order(108,110,167,252,256)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:99851"
     Site            order(109..111,162..163,165..166,207..208,252,256)
                     /site_type="other"
                     /note="putative substrate binding site [chemical binding]"
                     /db_xref="CDD:99851"
     CDS             1..518
                     /gene="EXD1"
                     /gene_synonym="EXDL1"
                     /coded_by="XM_047432209.1:208..1764"
                     /db_xref="GeneID:161829"
                     /db_xref="HGNC:HGNC:28507"
ORIGIN      
        1 msqnqeffwn fgkvelldev eqgsvrakas svslhaertw mekmkvedln vcepaspape
       61 apatsllndl kyspseeeev tytvinqfqq kfgaailhik kqnvlsvaae ganvcrhgkl
      121 cwlqvatncr vylfdifllg srafhnglqm iledkrilkv ihdcrwlsdc lshqygilln
      181 nvfdtqvadv lqfsmetggy lpncittlqe slikhlqvap kylsflekrq kliqenpevw
      241 firpvspsll kilaleatyl lplrlallde mmsdlttlvd gylntyregs adrlggtept
      301 cmelpeellq lkdfqkqrre kaareyrvna qgllirtvlq pkklvtetag keekvkgflf
      361 gknfridkap sftsqdfhgd vnllkeesln kqatnpqhlp pteegetsed ssnklictks
      421 kgsedqritq kehfmtpkhe fqaslslkee teqllmvenk edlkctkqav smssfpqetr
      481 vspsdtfypi rktvvstlpp cpalekidsw ispflnlp
//
LOCUS       XP_047288166             514 aa            linear   PRI 05-AUG-2025
DEFINITION  piRNA biogenesis protein EXD1 isoform X3 [Homo sapiens].
ACCESSION   XP_047288166
VERSION     XP_047288166.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432210.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..514
                     /product="piRNA biogenesis protein EXD1 isoform X3"
                     /calculated_mol_wt=58204
     Region          89..287
                     /region_name="Egl_like_exo"
                     /note="DEDDy 3'-5' exonuclease domain of Drosophila
                     Egalitarian (Egl) and similar proteins; cd06148"
                     /db_xref="CDD:99851"
     Site            order(104..107,158..159,161..163,203..204,248,252)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:99851"
     Site            order(104,106,163,248,252)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:99851"
     Site            order(105..107,158..159,161..162,203..204,248,252)
                     /site_type="other"
                     /note="putative substrate binding site [chemical binding]"
                     /db_xref="CDD:99851"
     CDS             1..514
                     /gene="EXD1"
                     /gene_synonym="EXDL1"
                     /coded_by="XM_047432210.1:165..1709"
                     /db_xref="GeneID:161829"
                     /db_xref="HGNC:HGNC:28507"
ORIGIN      
        1 medseflayv elldeveqgs vrakassvsl haertwmekm kvedlnvcep aspapeapat
       61 sllndlkysp seeeevtytv inqfqqkfga ailhikkqnv lsvaaeganv crhgklcwlq
      121 vatncrvylf difllgsraf hnglqmiled krilkvihdc rwlsdclshq ygillnnvfd
      181 tqvadvlqfs metggylpnc ittlqeslik hlqvapkyls flekrqkliq enpevwfirp
      241 vspsllkila leatyllplr lalldemmsd lttlvdgyln tyregsadrl ggteptcmel
      301 peellqlkdf qkqrrekaar eyrvnaqgll irtvlqpkkl vtetagkeek vkgflfgknf
      361 ridkapsfts qdfhgdvnll keeslnkqat npqhlpptee getsedssnk lictkskgse
      421 dqritqkehf mtpkhefqas lslkeeteql lmvenkedlk ctkqavsmss fpqetrvsps
      481 dtfypirktv vstlppcpal ekidswispf lnlp
//
LOCUS       XP_011519602             478 aa            linear   PRI 05-AUG-2025
DEFINITION  piRNA biogenesis protein EXD1 isoform X4 [Homo sapiens].
ACCESSION   XP_011519602
VERSION     XP_011519602.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521300.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..478
                     /product="piRNA biogenesis protein EXD1 isoform X4"
                     /calculated_mol_wt=54138
     Region          53..251
                     /region_name="Egl_like_exo"
                     /note="DEDDy 3'-5' exonuclease domain of Drosophila
                     Egalitarian (Egl) and similar proteins; cd06148"
                     /db_xref="CDD:99851"
     Site            order(68..71,122..123,125..127,167..168,212,216)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:99851"
     Site            order(68,70,127,212,216)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:99851"
     Site            order(69..71,122..123,125..126,167..168,212,216)
                     /site_type="other"
                     /note="putative substrate binding site [chemical binding]"
                     /db_xref="CDD:99851"
     CDS             1..478
                     /gene="EXD1"
                     /gene_synonym="EXDL1"
                     /coded_by="XM_011521300.3:104..1540"
                     /db_xref="GeneID:161829"
                     /db_xref="HGNC:HGNC:28507"
ORIGIN      
        1 mekmkvedln vcepaspape apatsllndl kyspseeeev tytvinqfqq kfgaailhik
       61 kqnvlsvaae ganvcrhgkl cwlqvatncr vylfdifllg srafhnglqm iledkrilkv
      121 ihdcrwlsdc lshqygilln nvfdtqvadv lqfsmetggy lpncittlqe slikhlqvap
      181 kylsflekrq kliqenpevw firpvspsll kilaleatyl lplrlallde mmsdlttlvd
      241 gylntyregs adrlggtept cmelpeellq lkdfqkqrre kaareyrvna qgllirtvlq
      301 pkklvtetag keekvkgflf gknfridkap sftsqdfhgd vnllkeesln kqatnpqhlp
      361 pteegetsed ssnklictks kgsedqritq kehfmtpkhe fqaslslkee teqllmvenk
      421 edlkctkqav smssfpqetr vspsdtfypi rktvvstlpp cpalekidsw ispflnlp
//
LOCUS       XP_016877459             478 aa            linear   PRI 05-AUG-2025
DEFINITION  piRNA biogenesis protein EXD1 isoform X4 [Homo sapiens].
ACCESSION   XP_016877459
VERSION     XP_016877459.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021970.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..478
                     /product="piRNA biogenesis protein EXD1 isoform X4"
                     /calculated_mol_wt=54138
     Region          53..251
                     /region_name="Egl_like_exo"
                     /note="DEDDy 3'-5' exonuclease domain of Drosophila
                     Egalitarian (Egl) and similar proteins; cd06148"
                     /db_xref="CDD:99851"
     Site            order(68..71,122..123,125..127,167..168,212,216)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:99851"
     Site            order(68,70,127,212,216)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:99851"
     Site            order(69..71,122..123,125..126,167..168,212,216)
                     /site_type="other"
                     /note="putative substrate binding site [chemical binding]"
                     /db_xref="CDD:99851"
     CDS             1..478
                     /gene="EXD1"
                     /gene_synonym="EXDL1"
                     /coded_by="XM_017021970.2:104..1540"
                     /db_xref="GeneID:161829"
                     /db_xref="HGNC:HGNC:28507"
ORIGIN      
        1 mekmkvedln vcepaspape apatsllndl kyspseeeev tytvinqfqq kfgaailhik
       61 kqnvlsvaae ganvcrhgkl cwlqvatncr vylfdifllg srafhnglqm iledkrilkv
      121 ihdcrwlsdc lshqygilln nvfdtqvadv lqfsmetggy lpncittlqe slikhlqvap
      181 kylsflekrq kliqenpevw firpvspsll kilaleatyl lplrlallde mmsdlttlvd
      241 gylntyregs adrlggtept cmelpeellq lkdfqkqrre kaareyrvna qgllirtvlq
      301 pkklvtetag keekvkgflf gknfridkap sftsqdfhgd vnllkeesln kqatnpqhlp
      361 pteegetsed ssnklictks kgsedqritq kehfmtpkhe fqaslslkee teqllmvenk
      421 edlkctkqav smssfpqetr vspsdtfypi rktvvstlpp cpalekidsw ispflnlp
//
LOCUS       XP_016877460             478 aa            linear   PRI 05-AUG-2025
DEFINITION  piRNA biogenesis protein EXD1 isoform X4 [Homo sapiens].
ACCESSION   XP_016877460
VERSION     XP_016877460.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021971.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..478
                     /product="piRNA biogenesis protein EXD1 isoform X4"
                     /calculated_mol_wt=54138
     Region          53..251
                     /region_name="Egl_like_exo"
                     /note="DEDDy 3'-5' exonuclease domain of Drosophila
                     Egalitarian (Egl) and similar proteins; cd06148"
                     /db_xref="CDD:99851"
     Site            order(68..71,122..123,125..127,167..168,212,216)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:99851"
     Site            order(68,70,127,212,216)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:99851"
     Site            order(69..71,122..123,125..126,167..168,212,216)
                     /site_type="other"
                     /note="putative substrate binding site [chemical binding]"
                     /db_xref="CDD:99851"
     CDS             1..478
                     /gene="EXD1"
                     /gene_synonym="EXDL1"
                     /coded_by="XM_017021971.2:102..1538"
                     /db_xref="GeneID:161829"
                     /db_xref="HGNC:HGNC:28507"
ORIGIN      
        1 mekmkvedln vcepaspape apatsllndl kyspseeeev tytvinqfqq kfgaailhik
       61 kqnvlsvaae ganvcrhgkl cwlqvatncr vylfdifllg srafhnglqm iledkrilkv
      121 ihdcrwlsdc lshqygilln nvfdtqvadv lqfsmetggy lpncittlqe slikhlqvap
      181 kylsflekrq kliqenpevw firpvspsll kilaleatyl lplrlallde mmsdlttlvd
      241 gylntyregs adrlggtept cmelpeellq lkdfqkqrre kaareyrvna qgllirtvlq
      301 pkklvtetag keekvkgflf gknfridkap sftsqdfhgd vnllkeesln kqatnpqhlp
      361 pteegetsed ssnklictks kgsedqritq kehfmtpkhe fqaslslkee teqllmvenk
      421 edlkctkqav smssfpqetr vspsdtfypi rktvvstlpp cpalekidsw ispflnlp
//
LOCUS       XP_047288167             478 aa            linear   PRI 05-AUG-2025
DEFINITION  piRNA biogenesis protein EXD1 isoform X4 [Homo sapiens].
ACCESSION   XP_047288167
VERSION     XP_047288167.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432211.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 17% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..478
                     /product="piRNA biogenesis protein EXD1 isoform X4"
                     /calculated_mol_wt=54138
     Region          53..251
                     /region_name="Egl_like_exo"
                     /note="DEDDy 3'-5' exonuclease domain of Drosophila
                     Egalitarian (Egl) and similar proteins; cd06148"
                     /db_xref="CDD:99851"
     Site            order(68..71,122..123,125..127,167..168,212,216)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:99851"
     Site            order(68,70,127,212,216)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:99851"
     Site            order(69..71,122..123,125..126,167..168,212,216)
                     /site_type="other"
                     /note="putative substrate binding site [chemical binding]"
                     /db_xref="CDD:99851"
     CDS             1..478
                     /gene="EXD1"
                     /gene_synonym="EXDL1"
                     /coded_by="XM_047432211.1:365..1801"
                     /db_xref="GeneID:161829"
                     /db_xref="HGNC:HGNC:28507"
ORIGIN      
        1 mekmkvedln vcepaspape apatsllndl kyspseeeev tytvinqfqq kfgaailhik
       61 kqnvlsvaae ganvcrhgkl cwlqvatncr vylfdifllg srafhnglqm iledkrilkv
      121 ihdcrwlsdc lshqygilln nvfdtqvadv lqfsmetggy lpncittlqe slikhlqvap
      181 kylsflekrq kliqenpevw firpvspsll kilaleatyl lplrlallde mmsdlttlvd
      241 gylntyregs adrlggtept cmelpeellq lkdfqkqrre kaareyrvna qgllirtvlq
      301 pkklvtetag keekvkgflf gknfridkap sftsqdfhgd vnllkeesln kqatnpqhlp
      361 pteegetsed ssnklictks kgsedqritq kehfmtpkhe fqaslslkee teqllmvenk
      421 edlkctkqav smssfpqetr vspsdtfypi rktvvstlpp cpalekidsw ispflnlp
//
LOCUS       XP_011519603             537 aa            linear   PRI 05-AUG-2025
DEFINITION  piRNA biogenesis protein EXD1 isoform X5 [Homo sapiens].
ACCESSION   XP_011519603
VERSION     XP_011519603.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521301.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..537
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..537
                     /product="piRNA biogenesis protein EXD1 isoform X5"
                     /calculated_mol_wt=60713
     Region          112..310
                     /region_name="Egl_like_exo"
                     /note="DEDDy 3'-5' exonuclease domain of Drosophila
                     Egalitarian (Egl) and similar proteins; cd06148"
                     /db_xref="CDD:99851"
     Site            order(127..130,181..182,184..186,226..227,271,275)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:99851"
     Site            order(127,129,186,271,275)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:99851"
     Site            order(128..130,181..182,184..185,226..227,271,275)
                     /site_type="other"
                     /note="putative substrate binding site [chemical binding]"
                     /db_xref="CDD:99851"
     CDS             1..537
                     /gene="EXD1"
                     /gene_synonym="EXDL1"
                     /coded_by="XM_011521301.3:165..1778"
                     /db_xref="GeneID:161829"
                     /db_xref="HGNC:HGNC:28507"
ORIGIN      
        1 medseflayv knvetgrsvp gvklffghei vnvelldeve qgsvrakass vslhaertwm
       61 ekmkvedlnv cepaspapea patsllndlk yspseeeevt ytvinqfqqk fgaailhikk
      121 qnvlsvaaeg anvcrhgklc wlqvatncrv ylfdifllgs rafhnglqmi ledkrilkvi
      181 hdcrwlsdcl shqygillnn vfdtqvadvl qfsmetggyl pncittlqes likhlqvapk
      241 ylsflekrqk liqenpevwf irpvspsllk ilaleatyll plrlalldem msdlttlvdg
      301 ylntyregsa drlggteptc melpeellql kdfqkqrrek aareyrvnaq gllirtvlqp
      361 kklvtetagk eekvkgflfg knfridkaps ftsqdfhgdv nllkeeslnk qatnpqhlpp
      421 teegetseds snklictksk gsedqritqk ehfmtpkhef qaslslkeet eqllmvenke
      481 dlkctkqavs mssfpqetrv spsdtfypir ktvvstlppc palekidswi spflnlp
//
LOCUS       XP_011519604             369 aa            linear   PRI 05-AUG-2025
DEFINITION  piRNA biogenesis protein EXD1 isoform X6 [Homo sapiens].
ACCESSION   XP_011519604
VERSION     XP_011519604.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521302.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..369
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..369
                     /product="piRNA biogenesis protein EXD1 isoform X6"
                     /calculated_mol_wt=42017
     Region          <1..142
                     /region_name="DnaQ_like_exo"
                     /note="DnaQ-like (or DEDD) 3'-5' exonuclease domain
                     superfamily; cl10012"
                     /db_xref="CDD:447876"
     CDS             1..369
                     /gene="EXD1"
                     /gene_synonym="EXDL1"
                     /coded_by="XM_011521302.3:246..1355"
                     /db_xref="GeneID:161829"
                     /db_xref="HGNC:HGNC:28507"
ORIGIN      
        1 miledkrilk vihdcrwlsd clshqygill nnvfdtqvad vlqfsmetgg ylpncittlq
       61 eslikhlqva pkylsflekr qkliqenpev wfirpvspsl lkilaleaty llplrlalld
      121 emmsdlttlv dgylntyreg sadrlggtep tcmelpeell qlkdfqkqrr ekaareyrvn
      181 aqgllirtvl qpkklvteta gkeekvkgfl fgknfridka psftsqdfhg dvnllkeesl
      241 nkqatnpqhl ppteegetse dssnklictk skgsedqrit qkehfmtpkh efqaslslke
      301 eteqllmven kedlkctkqa vsmssfpqet rvspsdtfyp irktvvstlp pcpalekids
      361 wispflnlp
//
LOCUS       XP_011519607             581 aa            linear   PRI 05-AUG-2025
DEFINITION  fibrous sheath-interacting protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_011519607
VERSION     XP_011519607.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521305.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..581
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..581
                     /product="fibrous sheath-interacting protein 1 isoform X1"
                     /calculated_mol_wt=65990
     Region          3..393
                     /region_name="FSIP1"
                     /note="FSIP1 family; pfam15554"
                     /db_xref="CDD:464764"
     CDS             1..581
                     /gene="FSIP1"
                     /gene_synonym="HSD10"
                     /coded_by="XM_011521305.4:222..1967"
                     /db_xref="GeneID:161835"
                     /db_xref="HGNC:HGNC:21674"
                     /db_xref="MIM:615795"
ORIGIN      
        1 mdiikgnldg iskpasnsri rpgsrssnas levlstepgs fkvdtasnln sgkedhsess
       61 ntenrrtsnd dkqescseki klaeegsded ldlvqhqiis ecsdepklke ldsqlqdaiq
      121 kmkkldkila kkqrrekeik kqglemrikl weeiksakys eawqskeeme ntkkflslta
      181 vseetvgpsh eeedtfssvf htqippeeye mqmqklnkdf tcdvernesl iksgkkpfsn
      241 tekielrgkh nqdfikrnie lakesrnpvv mvdrekkrlv ellkdldekd sglsssegdq
      301 sgwvvpvkgy elavtqhqql aeidiklqel saasptissf sprlenrnnq kpdrdgernm
      361 evtpgekilr ntkeqrdlhn rlreideklk mmkenvlest sclseeqlkc lldecilkqk
      421 siiklsserk kediedvtpv fpqlsrsiis kllnesetkv qktevedadm leseeceask
      481 gyyltkaltg hnmsealvte aenmkclqfs kdviisdtkd yfmsktlgig rlkrpsfldd
      541 plygisvsls sedqhlklss pentiadeqe tkdaaeecke p
//
LOCUS       XP_011519608             581 aa            linear   PRI 05-AUG-2025
DEFINITION  fibrous sheath-interacting protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_011519608
VERSION     XP_011519608.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521306.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..581
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..581
                     /product="fibrous sheath-interacting protein 1 isoform X1"
                     /calculated_mol_wt=65990
     Region          3..393
                     /region_name="FSIP1"
                     /note="FSIP1 family; pfam15554"
                     /db_xref="CDD:464764"
     CDS             1..581
                     /gene="FSIP1"
                     /gene_synonym="HSD10"
                     /coded_by="XM_011521306.3:508..2253"
                     /db_xref="GeneID:161835"
                     /db_xref="HGNC:HGNC:21674"
                     /db_xref="MIM:615795"
ORIGIN      
        1 mdiikgnldg iskpasnsri rpgsrssnas levlstepgs fkvdtasnln sgkedhsess
       61 ntenrrtsnd dkqescseki klaeegsded ldlvqhqiis ecsdepklke ldsqlqdaiq
      121 kmkkldkila kkqrrekeik kqglemrikl weeiksakys eawqskeeme ntkkflslta
      181 vseetvgpsh eeedtfssvf htqippeeye mqmqklnkdf tcdvernesl iksgkkpfsn
      241 tekielrgkh nqdfikrnie lakesrnpvv mvdrekkrlv ellkdldekd sglsssegdq
      301 sgwvvpvkgy elavtqhqql aeidiklqel saasptissf sprlenrnnq kpdrdgernm
      361 evtpgekilr ntkeqrdlhn rlreideklk mmkenvlest sclseeqlkc lldecilkqk
      421 siiklsserk kediedvtpv fpqlsrsiis kllnesetkv qktevedadm leseeceask
      481 gyyltkaltg hnmsealvte aenmkclqfs kdviisdtkd yfmsktlgig rlkrpsfldd
      541 plygisvsls sedqhlklss pentiadeqe tkdaaeecke p
//
LOCUS       XP_047288168             433 aa            linear   PRI 05-AUG-2025
DEFINITION  fibrous sheath-interacting protein 1 isoform X2 [Homo sapiens].
ACCESSION   XP_047288168
VERSION     XP_047288168.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432212.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..433
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..433
                     /product="fibrous sheath-interacting protein 1 isoform X2"
                     /calculated_mol_wt=49260
     Region          3..393
                     /region_name="FSIP1"
                     /note="FSIP1 family; pfam15554"
                     /db_xref="CDD:464764"
     CDS             1..433
                     /gene="FSIP1"
                     /gene_synonym="HSD10"
                     /coded_by="XM_047432212.1:125..1426"
                     /db_xref="GeneID:161835"
                     /db_xref="HGNC:HGNC:21674"
                     /db_xref="MIM:615795"
ORIGIN      
        1 mdiikgnldg iskpasnsri rpgsrssnas levlstepgs fkvdtasnln sgkedhsess
       61 ntenrrtsnd dkqescseki klaeegsded ldlvqhqiis ecsdepklke ldsqlqdaiq
      121 kmkkldkila kkqrrekeik kqglemrikl weeiksakys eawqskeeme ntkkflslta
      181 vseetvgpsh eeedtfssvf htqippeeye mqmqklnkdf tcdvernesl iksgkkpfsn
      241 tekielrgkh nqdfikrnie lakesrnpvv mvdrekkrlv ellkdldekd sglsssegdq
      301 sgwvvpvkgy elavtqhqql aeidiklqel saasptissf sprlenrnnq kpdrdgernm
      361 evtpgekilr ntkeqrdlhn rlreideklk mmkenvafln lgvtsedefg khraecltsf
      421 lyaaeldvds vci
//
LOCUS       XP_011519611             402 aa            linear   PRI 05-AUG-2025
DEFINITION  fibrous sheath-interacting protein 1 isoform X3 [Homo sapiens].
ACCESSION   XP_011519611
VERSION     XP_011519611.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521309.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..402
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..402
                     /product="fibrous sheath-interacting protein 1 isoform X3"
                     /calculated_mol_wt=45842
     Region          3..393
                     /region_name="FSIP1"
                     /note="FSIP1 family; pfam15554"
                     /db_xref="CDD:464764"
     CDS             1..402
                     /gene="FSIP1"
                     /gene_synonym="HSD10"
                     /coded_by="XM_011521309.4:222..1430"
                     /db_xref="GeneID:161835"
                     /db_xref="HGNC:HGNC:21674"
                     /db_xref="MIM:615795"
ORIGIN      
        1 mdiikgnldg iskpasnsri rpgsrssnas levlstepgs fkvdtasnln sgkedhsess
       61 ntenrrtsnd dkqescseki klaeegsded ldlvqhqiis ecsdepklke ldsqlqdaiq
      121 kmkkldkila kkqrrekeik kqglemrikl weeiksakys eawqskeeme ntkkflslta
      181 vseetvgpsh eeedtfssvf htqippeeye mqmqklnkdf tcdvernesl iksgkkpfsn
      241 tekielrgkh nqdfikrnie lakesrnpvv mvdrekkrlv ellkdldekd sglsssegdq
      301 sgwvvpvkgy elavtqhqql aeidiklqel saasptissf sprlenrnnq kpdrdgernm
      361 evtpgekilr ntkeqrdlhn rlreideklk mmkenvtklv vs
//
LOCUS       XP_011519613             371 aa            linear   PRI 05-AUG-2025
DEFINITION  fibrous sheath-interacting protein 1 isoform X4 [Homo sapiens].
ACCESSION   XP_011519613
VERSION     XP_011519613.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521311.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..371
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..371
                     /product="fibrous sheath-interacting protein 1 isoform X4"
                     /calculated_mol_wt=42217
     Region          <1..183
                     /region_name="FSIP1"
                     /note="FSIP1 family; pfam15554"
                     /db_xref="CDD:464764"
     CDS             1..371
                     /gene="FSIP1"
                     /gene_synonym="HSD10"
                     /coded_by="XM_011521311.4:1412..2527"
                     /db_xref="GeneID:161835"
                     /db_xref="HGNC:HGNC:21674"
                     /db_xref="MIM:615795"
ORIGIN      
        1 mqmqklnkdf tcdvernesl iksgkkpfsn tekielrgkh nqdfikrnie lakesrnpvv
       61 mvdrekkrlv ellkdldekd sglsssegdq sgwvvpvkgy elavtqhqql aeidiklqel
      121 saasptissf sprlenrnnq kpdrdgernm evtpgekilr ntkeqrdlhn rlreideklk
      181 mmkenvlest sclseeqlkc lldecilkqk siiklsserk kediedvtpv fpqlsrsiis
      241 kllnesetkv qktevedadm leseeceask gyyltkaltg hnmsealvte aenmkclqfs
      301 kdviisdtkd yfmsktlgig rlkrpsfldd plygisvsls sedqhlklss pentiadeqe
      361 tkdaaeecke p
//
LOCUS       XP_016877461             371 aa            linear   PRI 05-AUG-2025
DEFINITION  fibrous sheath-interacting protein 1 isoform X4 [Homo sapiens].
ACCESSION   XP_016877461
VERSION     XP_016877461.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021972.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..371
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..371
                     /product="fibrous sheath-interacting protein 1 isoform X4"
                     /calculated_mol_wt=42217
     Region          <1..183
                     /region_name="FSIP1"
                     /note="FSIP1 family; pfam15554"
                     /db_xref="CDD:464764"
     CDS             1..371
                     /gene="FSIP1"
                     /gene_synonym="HSD10"
                     /coded_by="XM_017021972.3:205..1320"
                     /db_xref="GeneID:161835"
                     /db_xref="HGNC:HGNC:21674"
                     /db_xref="MIM:615795"
ORIGIN      
        1 mqmqklnkdf tcdvernesl iksgkkpfsn tekielrgkh nqdfikrnie lakesrnpvv
       61 mvdrekkrlv ellkdldekd sglsssegdq sgwvvpvkgy elavtqhqql aeidiklqel
      121 saasptissf sprlenrnnq kpdrdgernm evtpgekilr ntkeqrdlhn rlreideklk
      181 mmkenvlest sclseeqlkc lldecilkqk siiklsserk kediedvtpv fpqlsrsiis
      241 kllnesetkv qktevedadm leseeceask gyyltkaltg hnmsealvte aenmkclqfs
      301 kdviisdtkd yfmsktlgig rlkrpsfldd plygisvsls sedqhlklss pentiadeqe
      361 tkdaaeecke p
//
LOCUS       XP_016877462            1189 aa            linear   PRI 05-AUG-2025
DEFINITION  A disintegrin and metalloproteinase with thrombospondin motifs 17
            isoform X1 [Homo sapiens].
ACCESSION   XP_016877462
VERSION     XP_016877462.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021973.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1189
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1189
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 17 isoform X1"
                     /calculated_mol_wt=131295
     Region          <81..180
                     /region_name="Pep_M12B_propep"
                     /note="Reprolysin family propeptide; pfam01562"
                     /db_xref="CDD:460254"
     Region          232..493
                     /region_name="ZnMc_ADAMTS_like"
                     /note="Zinc-dependent metalloprotease, ADAMTS_like
                     subgroup. ADAMs (A Disintegrin And Metalloprotease) are
                     glycoproteins, which play roles in cell signaling, cell
                     fusion, and cell-cell interactions. This particular
                     subfamily represents domain architectures that...;
                     cd04273"
                     /db_xref="CDD:239801"
     Site            order(433..434,437,443)
                     /site_type="active"
                     /db_xref="CDD:239801"
     Region          510..577
                     /region_name="ADAMTS_CR_2"
                     /note="ADAMTS cysteine-rich domain 2; pfam17771"
                     /db_xref="CDD:465496"
     Region          590..642
                     /region_name="TSP1"
                     /note="Thrombospondin type 1 repeats; smart00209"
                     /db_xref="CDD:214559"
     Region          <674..743
                     /region_name="ADAMTS_CR_3"
                     /note="ADAMTS cysteine-rich domain; pfam19236"
                     /db_xref="CDD:437068"
     Region          781..877
                     /region_name="ADAMTS_spacer1"
                     /note="ADAM-TS Spacer 1; pfam05986"
                     /db_xref="CDD:461796"
     Region          903..955
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          959..1015
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          1019..1061
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          1070..1117
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     CDS             1..1189
                     /gene="ADAMTS17"
                     /gene_synonym="WMS4"
                     /coded_by="XM_017021973.3:77..3646"
                     /db_xref="GeneID:170691"
                     /db_xref="HGNC:HGNC:17109"
                     /db_xref="MIM:607511"
ORIGIN      
        1 mcdgallppl vlpvllllvw gldpgtavgd aaadvevvlp wrvrpddvhl pplpaapgpr
       61 rrrrprtppa aprarpgera lllhlpafgr dlylqlrrdl rflsrgfeve eagaarrrgr
      121 paelcfysgr vlghpgslvs lsacgaaggl vgliqlgqeq vliqplnnsq gpfsgrehli
      181 rrkwsltpsp saeaqrpeql ckvltekkkp twgrpsrdwr errnairlts ehtvetlvva
      241 dadmvqyhga eaaqrfiltv mnmvynmfqh qslgikiniq vtklvllrqr paklsighhg
      301 erslesfchw qneeyggary lgnnqvpggk ddpplvdaav fvtrtdfcvh kdepcdtvvp
      361 papfdvregp gsppwwclgr elpeangsqr vipdhsiskt wegiaylggv csakrkcvla
      421 ednglnlaft iahelghnlg mnhdddhssc agrshimsge wvkgrnpsdl swsscsrddl
      481 enflkskvst cllvtdprsq htvrlphklp gmhysaneqc qilfgmnatf crnmehlmca
      541 glwclvegdt scktkldppl dgtecgadkw cragecvskt pipehvdgdw spwgawsmcs
      601 rtcgtgarfr qrkcdnpppg pggthcpgas vehavcenlp cpkglpsfrd qqcqahdrls
      661 pkkkglltav vvddkpcely csplgkespl lvadrvldgt pcgpyetdlc vhgkcqkigc
      721 dgiigsaake drcgvcsgdg ktchlvkgdf shargtvknd lctkvstcvm aeavpkcfsc
      781 yieaavipag arrirvvedk pahsflalkd sgkgsinsdw kielpgefqi agttvryvrr
      841 glwekisakg ptklplhlmv llfhdqdygi hyeytvpvnr taenqsepek pqdslfiwth
      901 sgwegcsvqc gggerrtivs ctrivnkttt lvndsdcpqa srpepqvrrc nlhpcqsrwv
      961 agpwspcsat cekgfqhrev tcvyqlqngt hvatrplycp gprpaavqsc egqdclsiwe
     1021 asewsqcsas cgkgvwkrtv actnsqgkcd astrpraeea cedysgcyew ktgdwstcss
     1081 tcgkglqsrv vqcmhkvtgr hgsecpalsk papyrqcyqe vcndrinant itsprlaalt
     1141 ykctrdqwtv ycrvireknl cqdmrwyqrc cqtcrdfyan kmrqpppns
//
LOCUS       XP_016877463            1181 aa            linear   PRI 05-AUG-2025
DEFINITION  A disintegrin and metalloproteinase with thrombospondin motifs 17
            isoform X2 [Homo sapiens].
ACCESSION   XP_016877463
VERSION     XP_016877463.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021974.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1181
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1181
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 17 isoform X2"
                     /calculated_mol_wt=128864
     Region          <81..180
                     /region_name="Pep_M12B_propep"
                     /note="Reprolysin family propeptide; pfam01562"
                     /db_xref="CDD:460254"
     Region          232..493
                     /region_name="ZnMc_ADAMTS_like"
                     /note="Zinc-dependent metalloprotease, ADAMTS_like
                     subgroup. ADAMs (A Disintegrin And Metalloprotease) are
                     glycoproteins, which play roles in cell signaling, cell
                     fusion, and cell-cell interactions. This particular
                     subfamily represents domain architectures that...;
                     cd04273"
                     /db_xref="CDD:239801"
     Site            order(433..434,437,443)
                     /site_type="active"
                     /db_xref="CDD:239801"
     Region          510..577
                     /region_name="ADAMTS_CR_2"
                     /note="ADAMTS cysteine-rich domain 2; pfam17771"
                     /db_xref="CDD:465496"
     Region          590..642
                     /region_name="TSP1"
                     /note="Thrombospondin type 1 repeats; smart00209"
                     /db_xref="CDD:214559"
     Region          <674..743
                     /region_name="ADAMTS_CR_3"
                     /note="ADAMTS cysteine-rich domain; pfam19236"
                     /db_xref="CDD:437068"
     Region          781..877
                     /region_name="ADAMTS_spacer1"
                     /note="ADAM-TS Spacer 1; pfam05986"
                     /db_xref="CDD:461796"
     Region          903..955
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          959..1015
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          1019..1061
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     CDS             1..1181
                     /gene="ADAMTS17"
                     /gene_synonym="WMS4"
                     /coded_by="XM_017021974.2:77..3622"
                     /db_xref="GeneID:170691"
                     /db_xref="HGNC:HGNC:17109"
                     /db_xref="MIM:607511"
ORIGIN      
        1 mcdgallppl vlpvllllvw gldpgtavgd aaadvevvlp wrvrpddvhl pplpaapgpr
       61 rrrrprtppa aprarpgera lllhlpafgr dlylqlrrdl rflsrgfeve eagaarrrgr
      121 paelcfysgr vlghpgslvs lsacgaaggl vgliqlgqeq vliqplnnsq gpfsgrehli
      181 rrkwsltpsp saeaqrpeql ckvltekkkp twgrpsrdwr errnairlts ehtvetlvva
      241 dadmvqyhga eaaqrfiltv mnmvynmfqh qslgikiniq vtklvllrqr paklsighhg
      301 erslesfchw qneeyggary lgnnqvpggk ddpplvdaav fvtrtdfcvh kdepcdtvvp
      361 papfdvregp gsppwwclgr elpeangsqr vipdhsiskt wegiaylggv csakrkcvla
      421 ednglnlaft iahelghnlg mnhdddhssc agrshimsge wvkgrnpsdl swsscsrddl
      481 enflkskvst cllvtdprsq htvrlphklp gmhysaneqc qilfgmnatf crnmehlmca
      541 glwclvegdt scktkldppl dgtecgadkw cragecvskt pipehvdgdw spwgawsmcs
      601 rtcgtgarfr qrkcdnpppg pggthcpgas vehavcenlp cpkglpsfrd qqcqahdrls
      661 pkkkglltav vvddkpcely csplgkespl lvadrvldgt pcgpyetdlc vhgkcqkigc
      721 dgiigsaake drcgvcsgdg ktchlvkgdf shargtvknd lctkvstcvm aeavpkcfsc
      781 yieaavipag arrirvvedk pahsflalkd sgkgsinsdw kielpgefqi agttvryvrr
      841 glwekisakg ptklplhlmv llfhdqdygi hyeytvpvnr taenqsepek pqdslfiwth
      901 sgwegcsvqc gggerrtivs ctrivnkttt lvndsdcpqa srpepqvrrc nlhpcqsrwv
      961 agpwspcsat cekgfqhrev tcvyqlqngt hvatrplycp gprpaavqsc egqdclsiwe
     1021 asewsqcsas cgkgvwkrtv actnsqgkcd astrpraeea cedysgcyew ktgdwstaap
     1081 alplgahwen ptasracrrn pkrsprqdag aldarlamlc gvlagpsllp wghlgqtslp
     1141 ftpgtpgqgp gdagtdragg hgvvagrsit eppgqhsreq g
//
LOCUS       XP_016877464            1166 aa            linear   PRI 05-AUG-2025
DEFINITION  A disintegrin and metalloproteinase with thrombospondin motifs 17
            isoform X3 [Homo sapiens].
ACCESSION   XP_016877464
VERSION     XP_016877464.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021975.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1166
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1166
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 17 isoform X3"
                     /calculated_mol_wt=128793
     Region          <81..180
                     /region_name="Pep_M12B_propep"
                     /note="Reprolysin family propeptide; pfam01562"
                     /db_xref="CDD:460254"
     Region          232..493
                     /region_name="ZnMc_ADAMTS_like"
                     /note="Zinc-dependent metalloprotease, ADAMTS_like
                     subgroup. ADAMs (A Disintegrin And Metalloprotease) are
                     glycoproteins, which play roles in cell signaling, cell
                     fusion, and cell-cell interactions. This particular
                     subfamily represents domain architectures that...;
                     cd04273"
                     /db_xref="CDD:239801"
     Site            order(433..434,437,443)
                     /site_type="active"
                     /db_xref="CDD:239801"
     Region          510..577
                     /region_name="ADAMTS_CR_2"
                     /note="ADAMTS cysteine-rich domain 2; pfam17771"
                     /db_xref="CDD:465496"
     Region          590..642
                     /region_name="TSP1"
                     /note="Thrombospondin type 1 repeats; smart00209"
                     /db_xref="CDD:214559"
     Region          <674..743
                     /region_name="ADAMTS_CR_3"
                     /note="ADAMTS cysteine-rich domain; pfam19236"
                     /db_xref="CDD:437068"
     Region          745..854
                     /region_name="ADAMTS_spacer1"
                     /note="ADAM-TS Spacer 1; pfam05986"
                     /db_xref="CDD:461796"
     Region          880..932
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          936..992
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          996..1038
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          1047..1094
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     CDS             1..1166
                     /gene="ADAMTS17"
                     /gene_synonym="WMS4"
                     /coded_by="XM_017021975.2:77..3577"
                     /db_xref="GeneID:170691"
                     /db_xref="HGNC:HGNC:17109"
                     /db_xref="MIM:607511"
ORIGIN      
        1 mcdgallppl vlpvllllvw gldpgtavgd aaadvevvlp wrvrpddvhl pplpaapgpr
       61 rrrrprtppa aprarpgera lllhlpafgr dlylqlrrdl rflsrgfeve eagaarrrgr
      121 paelcfysgr vlghpgslvs lsacgaaggl vgliqlgqeq vliqplnnsq gpfsgrehli
      181 rrkwsltpsp saeaqrpeql ckvltekkkp twgrpsrdwr errnairlts ehtvetlvva
      241 dadmvqyhga eaaqrfiltv mnmvynmfqh qslgikiniq vtklvllrqr paklsighhg
      301 erslesfchw qneeyggary lgnnqvpggk ddpplvdaav fvtrtdfcvh kdepcdtvvp
      361 papfdvregp gsppwwclgr elpeangsqr vipdhsiskt wegiaylggv csakrkcvla
      421 ednglnlaft iahelghnlg mnhdddhssc agrshimsge wvkgrnpsdl swsscsrddl
      481 enflkskvst cllvtdprsq htvrlphklp gmhysaneqc qilfgmnatf crnmehlmca
      541 glwclvegdt scktkldppl dgtecgadkw cragecvskt pipehvdgdw spwgawsmcs
      601 rtcgtgarfr qrkcdnpppg pggthcpgas vehavcenlp cpkglpsfrd qqcqahdrls
      661 pkkkglltav vvddkpcely csplgkespl lvadrvldgt pcgpyetdlc vhgkcqkigc
      721 dgiigsaake drcgvcsgdg ktchlvkgdf shargtgyie aavipagarr irvvedkpah
      781 sflalkdsgk gsinsdwkie lpgefqiagt tvryvrrglw ekisakgptk lplhlmvllf
      841 hdqdygihye ytvpvnrtae nqsepekpqd slfiwthsgw egcsvqcggg errtivsctr
      901 ivnktttlvn dsdcpqasrp epqvrrcnlh pcqsrwvagp wspcsatcek gfqhrevtcv
      961 yqlqngthva trplycpgpr paavqscegq dclsiwease wsqcsascgk gvwkrtvact
     1021 nsqgkcdast rpraeeaced ysgcyewktg dwstcsstcg kglqsrvvqc mhkvtgrhgs
     1081 ecpalskpap yrqcyqevcn drinantits prlaaltykc trdqwtvycr vireknlcqd
     1141 mrwyqrccqt crdfyankmr qpppns
//
LOCUS       XP_011519614            1145 aa            linear   PRI 05-AUG-2025
DEFINITION  A disintegrin and metalloproteinase with thrombospondin motifs 17
            isoform X4 [Homo sapiens].
ACCESSION   XP_011519614
VERSION     XP_011519614.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521312.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1145
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1145
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 17 isoform X4"
                     /calculated_mol_wt=126417
     Region          <81..180
                     /region_name="Pep_M12B_propep"
                     /note="Reprolysin family propeptide; pfam01562"
                     /db_xref="CDD:460254"
     Region          232..449
                     /region_name="ZnMc_ADAMTS_like"
                     /note="Zinc-dependent metalloprotease, ADAMTS_like
                     subgroup. ADAMs (A Disintegrin And Metalloprotease) are
                     glycoproteins, which play roles in cell signaling, cell
                     fusion, and cell-cell interactions. This particular
                     subfamily represents domain architectures that...;
                     cd04273"
                     /db_xref="CDD:239801"
     Site            order(389..390,393,399)
                     /site_type="active"
                     /db_xref="CDD:239801"
     Region          466..533
                     /region_name="ADAMTS_CR_2"
                     /note="ADAMTS cysteine-rich domain 2; pfam17771"
                     /db_xref="CDD:465496"
     Region          546..598
                     /region_name="TSP1"
                     /note="Thrombospondin type 1 repeats; smart00209"
                     /db_xref="CDD:214559"
     Region          <630..699
                     /region_name="ADAMTS_CR_3"
                     /note="ADAMTS cysteine-rich domain; pfam19236"
                     /db_xref="CDD:437068"
     Region          737..833
                     /region_name="ADAMTS_spacer1"
                     /note="ADAM-TS Spacer 1; pfam05986"
                     /db_xref="CDD:461796"
     Region          859..911
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          915..971
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          975..1017
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          1026..1073
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     CDS             1..1145
                     /gene="ADAMTS17"
                     /gene_synonym="WMS4"
                     /coded_by="XM_011521312.3:77..3514"
                     /db_xref="GeneID:170691"
                     /db_xref="HGNC:HGNC:17109"
                     /db_xref="MIM:607511"
ORIGIN      
        1 mcdgallppl vlpvllllvw gldpgtavgd aaadvevvlp wrvrpddvhl pplpaapgpr
       61 rrrrprtppa aprarpgera lllhlpafgr dlylqlrrdl rflsrgfeve eagaarrrgr
      121 paelcfysgr vlghpgslvs lsacgaaggl vgliqlgqeq vliqplnnsq gpfsgrehli
      181 rrkwsltpsp saeaqrpeql ckvltekkkp twgrpsrdwr errnairlts ehtvetlvva
      241 dadmvqyhga eaaqrfiltv mnmvynmfqh qslgikiniq vtklvllrqr paklsighhg
      301 erslesfchw qneeyggary lgnnqvpggk ddpplvdaav fvtrtdfcvh kdepcdtvgi
      361 aylggvcsak rkcvlaedng lnlaftiahe lghnlgmnhd ddhsscagrs himsgewvkg
      421 rnpsdlswss csrddlenfl kskvstcllv tdprsqhtvr lphklpgmhy saneqcqilf
      481 gmnatfcrnm ehlmcaglwc lvegdtsckt kldppldgte cgadkwcrag ecvsktpipe
      541 hvdgdwspwg awsmcsrtcg tgarfrqrkc dnpppgpggt hcpgasveha vcenlpcpkg
      601 lpsfrdqqcq ahdrlspkkk glltavvvdd kpcelycspl gkespllvad rvldgtpcgp
      661 yetdlcvhgk cqkigcdgii gsaakedrcg vcsgdgktch lvkgdfshar gtvkndlctk
      721 vstcvmaeav pkcfscyiea avipagarri rvvedkpahs flalkdsgkg sinsdwkiel
      781 pgefqiagtt vryvrrglwe kisakgptkl plhlmvllfh dqdygihyey tvpvnrtaen
      841 qsepekpqds lfiwthsgwe gcsvqcggge rrtivsctri vnktttlvnd sdcpqasrpe
      901 pqvrrcnlhp cqsrwvagpw spcsatcekg fqhrevtcvy qlqngthvat rplycpgprp
      961 aavqscegqd clsiweasew sqcsascgkg vwkrtvactn sqgkcdastr praeeacedy
     1021 sgcyewktgd wstcsstcgk glqsrvvqcm hkvtgrhgse cpalskpapy rqcyqevcnd
     1081 rinantitsp rlaaltykct rdqwtvycrv ireknlcqdm rwyqrccqtc rdfyankmrq
     1141 pppns
//
LOCUS       XP_005254929            1122 aa            linear   PRI 05-AUG-2025
DEFINITION  A disintegrin and metalloproteinase with thrombospondin motifs 17
            isoform X5 [Homo sapiens].
ACCESSION   XP_005254929
VERSION     XP_005254929.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254872.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1122
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1122
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 17 isoform X5"
                     /calculated_mol_wt=123915
     Region          <81..180
                     /region_name="Pep_M12B_propep"
                     /note="Reprolysin family propeptide; pfam01562"
                     /db_xref="CDD:460254"
     Region          232..449
                     /region_name="ZnMc_ADAMTS_like"
                     /note="Zinc-dependent metalloprotease, ADAMTS_like
                     subgroup. ADAMs (A Disintegrin And Metalloprotease) are
                     glycoproteins, which play roles in cell signaling, cell
                     fusion, and cell-cell interactions. This particular
                     subfamily represents domain architectures that...;
                     cd04273"
                     /db_xref="CDD:239801"
     Site            order(389..390,393,399)
                     /site_type="active"
                     /db_xref="CDD:239801"
     Region          466..533
                     /region_name="ADAMTS_CR_2"
                     /note="ADAMTS cysteine-rich domain 2; pfam17771"
                     /db_xref="CDD:465496"
     Region          546..598
                     /region_name="TSP1"
                     /note="Thrombospondin type 1 repeats; smart00209"
                     /db_xref="CDD:214559"
     Region          <630..699
                     /region_name="ADAMTS_CR_3"
                     /note="ADAMTS cysteine-rich domain; pfam19236"
                     /db_xref="CDD:437068"
     Region          701..810
                     /region_name="ADAMTS_spacer1"
                     /note="ADAM-TS Spacer 1; pfam05986"
                     /db_xref="CDD:461796"
     Region          836..888
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          892..948
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          952..994
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          1003..1050
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     CDS             1..1122
                     /gene="ADAMTS17"
                     /gene_synonym="WMS4"
                     /coded_by="XM_005254872.4:77..3445"
                     /db_xref="GeneID:170691"
                     /db_xref="HGNC:HGNC:17109"
                     /db_xref="MIM:607511"
ORIGIN      
        1 mcdgallppl vlpvllllvw gldpgtavgd aaadvevvlp wrvrpddvhl pplpaapgpr
       61 rrrrprtppa aprarpgera lllhlpafgr dlylqlrrdl rflsrgfeve eagaarrrgr
      121 paelcfysgr vlghpgslvs lsacgaaggl vgliqlgqeq vliqplnnsq gpfsgrehli
      181 rrkwsltpsp saeaqrpeql ckvltekkkp twgrpsrdwr errnairlts ehtvetlvva
      241 dadmvqyhga eaaqrfiltv mnmvynmfqh qslgikiniq vtklvllrqr paklsighhg
      301 erslesfchw qneeyggary lgnnqvpggk ddpplvdaav fvtrtdfcvh kdepcdtvgi
      361 aylggvcsak rkcvlaedng lnlaftiahe lghnlgmnhd ddhsscagrs himsgewvkg
      421 rnpsdlswss csrddlenfl kskvstcllv tdprsqhtvr lphklpgmhy saneqcqilf
      481 gmnatfcrnm ehlmcaglwc lvegdtsckt kldppldgte cgadkwcrag ecvsktpipe
      541 hvdgdwspwg awsmcsrtcg tgarfrqrkc dnpppgpggt hcpgasveha vcenlpcpkg
      601 lpsfrdqqcq ahdrlspkkk glltavvvdd kpcelycspl gkespllvad rvldgtpcgp
      661 yetdlcvhgk cqkigcdgii gsaakedrcg vcsgdgktch lvkgdfshar gtgyieaavi
      721 pagarrirvv edkpahsfla lkdsgkgsin sdwkielpge fqiagttvry vrrglwekis
      781 akgptklplh lmvllfhdqd ygihyeytvp vnrtaenqse pekpqdslfi wthsgwegcs
      841 vqcgggerrt ivsctrivnk tttlvndsdc pqasrpepqv rrcnlhpcqs rwvagpwspc
      901 satcekgfqh revtcvyqlq ngthvatrpl ycpgprpaav qscegqdcls iweasewsqc
      961 sascgkgvwk rtvactnsqg kcdastrpra eeacedysgc yewktgdwst csstcgkglq
     1021 srvvqcmhkv tgrhgsecpa lskpapyrqc yqevcndrin antitsprla altykctrdq
     1081 wtvycrvire knlcqdmrwy qrccqtcrdf yankmrqppp ns
//
LOCUS       XP_016877466             823 aa            linear   PRI 05-AUG-2025
DEFINITION  A disintegrin and metalloproteinase with thrombospondin motifs 17
            isoform X6 [Homo sapiens].
ACCESSION   XP_016877466
VERSION     XP_016877466.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021977.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..823
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..823
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 17 isoform X6"
                     /calculated_mol_wt=89914
     Region          <81..180
                     /region_name="Pep_M12B_propep"
                     /note="Reprolysin family propeptide; pfam01562"
                     /db_xref="CDD:460254"
     Region          232..493
                     /region_name="ZnMc_ADAMTS_like"
                     /note="Zinc-dependent metalloprotease, ADAMTS_like
                     subgroup. ADAMs (A Disintegrin And Metalloprotease) are
                     glycoproteins, which play roles in cell signaling, cell
                     fusion, and cell-cell interactions. This particular
                     subfamily represents domain architectures that...;
                     cd04273"
                     /db_xref="CDD:239801"
     Site            order(433..434,437,443)
                     /site_type="active"
                     /db_xref="CDD:239801"
     Region          510..577
                     /region_name="ADAMTS_CR_2"
                     /note="ADAMTS cysteine-rich domain 2; pfam17771"
                     /db_xref="CDD:465496"
     Region          590..642
                     /region_name="TSP1"
                     /note="Thrombospondin type 1 repeats; smart00209"
                     /db_xref="CDD:214559"
     Region          <674..743
                     /region_name="ADAMTS_CR_3"
                     /note="ADAMTS cysteine-rich domain; pfam19236"
                     /db_xref="CDD:437068"
     CDS             1..823
                     /gene="ADAMTS17"
                     /gene_synonym="WMS4"
                     /coded_by="XM_017021977.2:77..2548"
                     /db_xref="GeneID:170691"
                     /db_xref="HGNC:HGNC:17109"
                     /db_xref="MIM:607511"
ORIGIN      
        1 mcdgallppl vlpvllllvw gldpgtavgd aaadvevvlp wrvrpddvhl pplpaapgpr
       61 rrrrprtppa aprarpgera lllhlpafgr dlylqlrrdl rflsrgfeve eagaarrrgr
      121 paelcfysgr vlghpgslvs lsacgaaggl vgliqlgqeq vliqplnnsq gpfsgrehli
      181 rrkwsltpsp saeaqrpeql ckvltekkkp twgrpsrdwr errnairlts ehtvetlvva
      241 dadmvqyhga eaaqrfiltv mnmvynmfqh qslgikiniq vtklvllrqr paklsighhg
      301 erslesfchw qneeyggary lgnnqvpggk ddpplvdaav fvtrtdfcvh kdepcdtvvp
      361 papfdvregp gsppwwclgr elpeangsqr vipdhsiskt wegiaylggv csakrkcvla
      421 ednglnlaft iahelghnlg mnhdddhssc agrshimsge wvkgrnpsdl swsscsrddl
      481 enflkskvst cllvtdprsq htvrlphklp gmhysaneqc qilfgmnatf crnmehlmca
      541 glwclvegdt scktkldppl dgtecgadkw cragecvskt pipehvdgdw spwgawsmcs
      601 rtcgtgarfr qrkcdnpppg pggthcpgas vehavcenlp cpkglpsfrd qqcqahdrls
      661 pkkkglltav vvddkpcely csplgkespl lvadrvldgt pcgpyetdlc vhgkcqkigc
      721 dgiigsaake drcgvcsgdg ktchlvkgdf shargtvknd lctkvstcvm aeavpkcfsc
      781 yieaavipag arrirvvedk pahsfldkqd papvirgwqa pgp
//
LOCUS       XP_016877467             823 aa            linear   PRI 05-AUG-2025
DEFINITION  A disintegrin and metalloproteinase with thrombospondin motifs 17
            isoform X7 [Homo sapiens].
ACCESSION   XP_016877467
VERSION     XP_016877467.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021978.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..823
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..823
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 17 isoform X7"
                     /calculated_mol_wt=90789
     Region          <37..127
                     /region_name="ZnMc"
                     /note="Zinc-dependent metalloprotease. This super-family
                     of metalloproteases contains two major branches, the
                     astacin-like proteases and the adamalysin/reprolysin-like
                     proteases. Both branches have wide phylogenetic
                     distribution, and contain sub-families, which...; cl00064"
                     /db_xref="CDD:469599"
     Site            order(67..68,71,77)
                     /site_type="active"
                     /db_xref="CDD:238124"
     Region          144..211
                     /region_name="ADAMTS_CR_2"
                     /note="ADAMTS cysteine-rich domain 2; pfam17771"
                     /db_xref="CDD:465496"
     Region          224..276
                     /region_name="TSP1"
                     /note="Thrombospondin type 1 repeats; smart00209"
                     /db_xref="CDD:214559"
     Region          <308..377
                     /region_name="ADAMTS_CR_3"
                     /note="ADAMTS cysteine-rich domain; pfam19236"
                     /db_xref="CDD:437068"
     Region          415..511
                     /region_name="ADAMTS_spacer1"
                     /note="ADAM-TS Spacer 1; pfam05986"
                     /db_xref="CDD:461796"
     Region          537..589
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          593..649
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          653..695
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          704..751
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     CDS             1..823
                     /gene="ADAMTS17"
                     /gene_synonym="WMS4"
                     /coded_by="XM_017021978.2:15275..17746"
                     /db_xref="GeneID:170691"
                     /db_xref="HGNC:HGNC:17109"
                     /db_xref="MIM:607511"
ORIGIN      
        1 mlplpphlgw iyfsstkktq ealvtsrate cfplfegiay lggvcsakrk cvlaedngln
       61 laftiahelg hnlgmnhddd hsscagrshi msgewvkgrn psdlswsscs rddlenflks
      121 kvstcllvtd prsqhtvrlp hklpgmhysa neqcqilfgm natfcrnmeh lmcaglwclv
      181 egdtscktkl dppldgtecg adkwcragec vsktpipehv dgdwspwgaw smcsrtcgtg
      241 arfrqrkcdn pppgpggthc pgasvehavc enlpcpkglp sfrdqqcqah drlspkkkgl
      301 ltavvvddkp celycsplgk espllvadrv ldgtpcgpye tdlcvhgkcq kigcdgiigs
      361 aakedrcgvc sgdgktchlv kgdfshargt vkndlctkvs tcvmaeavpk cfscyieaav
      421 ipagarrirv vedkpahsfl alkdsgkgsi nsdwkielpg efqiagttvr yvrrglweki
      481 sakgptklpl hlmvllfhdq dygihyeytv pvnrtaenqs epekpqdslf iwthsgwegc
      541 svqcgggerr tivsctrivn ktttlvndsd cpqasrpepq vrrcnlhpcq srwvagpwsp
      601 csatcekgfq hrevtcvyql qngthvatrp lycpgprpaa vqscegqdcl siweasewsq
      661 csascgkgvw krtvactnsq gkcdastrpr aeeacedysg cyewktgdws tcsstcgkgl
      721 qsrvvqcmhk vtgrhgsecp alskpapyrq cyqevcndri nantitsprl aaltykctrd
      781 qwtvycrvir eknlcqdmrw yqrccqtcrd fyankmrqpp pns
//
LOCUS       XP_016877468             749 aa            linear   PRI 05-AUG-2025
DEFINITION  A disintegrin and metalloproteinase with thrombospondin motifs 17
            isoform X8 [Homo sapiens].
ACCESSION   XP_016877468
VERSION     XP_016877468.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021979.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..749
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..749
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 17 isoform X8"
                     /calculated_mol_wt=82758
     Region          <1..53
                     /region_name="ZnMc"
                     /note="Zinc-dependent metalloprotease. This super-family
                     of metalloproteases contains two major branches, the
                     astacin-like proteases and the adamalysin/reprolysin-like
                     proteases. Both branches have wide phylogenetic
                     distribution, and contain sub-families, which...; cl00064"
                     /db_xref="CDD:469599"
     Region          70..137
                     /region_name="ADAMTS_CR_2"
                     /note="ADAMTS cysteine-rich domain 2; pfam17771"
                     /db_xref="CDD:465496"
     Region          150..202
                     /region_name="TSP1"
                     /note="Thrombospondin type 1 repeats; smart00209"
                     /db_xref="CDD:214559"
     Region          <234..303
                     /region_name="ADAMTS_CR_3"
                     /note="ADAMTS cysteine-rich domain; pfam19236"
                     /db_xref="CDD:437068"
     Region          341..437
                     /region_name="ADAMTS_spacer1"
                     /note="ADAM-TS Spacer 1; pfam05986"
                     /db_xref="CDD:461796"
     Region          463..515
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          519..575
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          579..621
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          630..677
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     CDS             1..749
                     /gene="ADAMTS17"
                     /gene_synonym="WMS4"
                     /coded_by="XM_017021979.2:52..2301"
                     /db_xref="GeneID:170691"
                     /db_xref="HGNC:HGNC:17109"
                     /db_xref="MIM:607511"
ORIGIN      
        1 mnhdddhssc agrshimsge wvkgrnpsdl swsscsrddl enflkskvst cllvtdprsq
       61 htvrlphklp gmhysaneqc qilfgmnatf crnmehlmca glwclvegdt scktkldppl
      121 dgtecgadkw cragecvskt pipehvdgdw spwgawsmcs rtcgtgarfr qrkcdnpppg
      181 pggthcpgas vehavcenlp cpkglpsfrd qqcqahdrls pkkkglltav vvddkpcely
      241 csplgkespl lvadrvldgt pcgpyetdlc vhgkcqkigc dgiigsaake drcgvcsgdg
      301 ktchlvkgdf shargtvknd lctkvstcvm aeavpkcfsc yieaavipag arrirvvedk
      361 pahsflalkd sgkgsinsdw kielpgefqi agttvryvrr glwekisakg ptklplhlmv
      421 llfhdqdygi hyeytvpvnr taenqsepek pqdslfiwth sgwegcsvqc gggerrtivs
      481 ctrivnkttt lvndsdcpqa srpepqvrrc nlhpcqsrwv agpwspcsat cekgfqhrev
      541 tcvyqlqngt hvatrplycp gprpaavqsc egqdclsiwe asewsqcsas cgkgvwkrtv
      601 actnsqgkcd astrpraeea cedysgcyew ktgdwstcss tcgkglqsrv vqcmhkvtgr
      661 hgsecpalsk papyrqcyqe vcndrinant itsprlaalt ykctrdqwtv ycrvireknl
      721 cqdmrwyqrc cqtcrdfyan kmrqpppns
//
LOCUS       XP_016877469             749 aa            linear   PRI 05-AUG-2025
DEFINITION  A disintegrin and metalloproteinase with thrombospondin motifs 17
            isoform X8 [Homo sapiens].
ACCESSION   XP_016877469
VERSION     XP_016877469.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021980.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..749
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..749
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 17 isoform X8"
                     /calculated_mol_wt=82758
     Region          <1..53
                     /region_name="ZnMc"
                     /note="Zinc-dependent metalloprotease. This super-family
                     of metalloproteases contains two major branches, the
                     astacin-like proteases and the adamalysin/reprolysin-like
                     proteases. Both branches have wide phylogenetic
                     distribution, and contain sub-families, which...; cl00064"
                     /db_xref="CDD:469599"
     Region          70..137
                     /region_name="ADAMTS_CR_2"
                     /note="ADAMTS cysteine-rich domain 2; pfam17771"
                     /db_xref="CDD:465496"
     Region          150..202
                     /region_name="TSP1"
                     /note="Thrombospondin type 1 repeats; smart00209"
                     /db_xref="CDD:214559"
     Region          <234..303
                     /region_name="ADAMTS_CR_3"
                     /note="ADAMTS cysteine-rich domain; pfam19236"
                     /db_xref="CDD:437068"
     Region          341..437
                     /region_name="ADAMTS_spacer1"
                     /note="ADAM-TS Spacer 1; pfam05986"
                     /db_xref="CDD:461796"
     Region          463..515
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          519..575
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          579..621
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          630..677
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     CDS             1..749
                     /gene="ADAMTS17"
                     /gene_synonym="WMS4"
                     /coded_by="XM_017021980.2:4694..6943"
                     /db_xref="GeneID:170691"
                     /db_xref="HGNC:HGNC:17109"
                     /db_xref="MIM:607511"
ORIGIN      
        1 mnhdddhssc agrshimsge wvkgrnpsdl swsscsrddl enflkskvst cllvtdprsq
       61 htvrlphklp gmhysaneqc qilfgmnatf crnmehlmca glwclvegdt scktkldppl
      121 dgtecgadkw cragecvskt pipehvdgdw spwgawsmcs rtcgtgarfr qrkcdnpppg
      181 pggthcpgas vehavcenlp cpkglpsfrd qqcqahdrls pkkkglltav vvddkpcely
      241 csplgkespl lvadrvldgt pcgpyetdlc vhgkcqkigc dgiigsaake drcgvcsgdg
      301 ktchlvkgdf shargtvknd lctkvstcvm aeavpkcfsc yieaavipag arrirvvedk
      361 pahsflalkd sgkgsinsdw kielpgefqi agttvryvrr glwekisakg ptklplhlmv
      421 llfhdqdygi hyeytvpvnr taenqsepek pqdslfiwth sgwegcsvqc gggerrtivs
      481 ctrivnkttt lvndsdcpqa srpepqvrrc nlhpcqsrwv agpwspcsat cekgfqhrev
      541 tcvyqlqngt hvatrplycp gprpaavqsc egqdclsiwe asewsqcsas cgkgvwkrtv
      601 actnsqgkcd astrpraeea cedysgcyew ktgdwstcss tcgkglqsrv vqcmhkvtgr
      661 hgsecpalsk papyrqcyqe vcndrinant itsprlaalt ykctrdqwtv ycrvireknl
      721 cqdmrwyqrc cqtcrdfyan kmrqpppns
//
LOCUS       XP_016877470             726 aa            linear   PRI 05-AUG-2025
DEFINITION  A disintegrin and metalloproteinase with thrombospondin motifs 17
            isoform X9 [Homo sapiens].
ACCESSION   XP_016877470
VERSION     XP_016877470.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021981.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..726
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..726
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 17 isoform X9"
                     /calculated_mol_wt=79790
     Region          <81..180
                     /region_name="Pep_M12B_propep"
                     /note="Reprolysin family propeptide; pfam01562"
                     /db_xref="CDD:460254"
     Region          232..493
                     /region_name="ZnMc_ADAMTS_like"
                     /note="Zinc-dependent metalloprotease, ADAMTS_like
                     subgroup. ADAMs (A Disintegrin And Metalloprotease) are
                     glycoproteins, which play roles in cell signaling, cell
                     fusion, and cell-cell interactions. This particular
                     subfamily represents domain architectures that...;
                     cd04273"
                     /db_xref="CDD:239801"
     Site            order(433..434,437,443)
                     /site_type="active"
                     /db_xref="CDD:239801"
     Region          510..577
                     /region_name="ADAMTS_CR_2"
                     /note="ADAMTS cysteine-rich domain 2; pfam17771"
                     /db_xref="CDD:465496"
     Region          590..642
                     /region_name="TSP1"
                     /note="Thrombospondin type 1 repeats; smart00209"
                     /db_xref="CDD:214559"
     CDS             1..726
                     /gene="ADAMTS17"
                     /gene_synonym="WMS4"
                     /coded_by="XM_017021981.2:77..2257"
                     /db_xref="GeneID:170691"
                     /db_xref="HGNC:HGNC:17109"
                     /db_xref="MIM:607511"
ORIGIN      
        1 mcdgallppl vlpvllllvw gldpgtavgd aaadvevvlp wrvrpddvhl pplpaapgpr
       61 rrrrprtppa aprarpgera lllhlpafgr dlylqlrrdl rflsrgfeve eagaarrrgr
      121 paelcfysgr vlghpgslvs lsacgaaggl vgliqlgqeq vliqplnnsq gpfsgrehli
      181 rrkwsltpsp saeaqrpeql ckvltekkkp twgrpsrdwr errnairlts ehtvetlvva
      241 dadmvqyhga eaaqrfiltv mnmvynmfqh qslgikiniq vtklvllrqr paklsighhg
      301 erslesfchw qneeyggary lgnnqvpggk ddpplvdaav fvtrtdfcvh kdepcdtvvp
      361 papfdvregp gsppwwclgr elpeangsqr vipdhsiskt wegiaylggv csakrkcvla
      421 ednglnlaft iahelghnlg mnhdddhssc agrshimsge wvkgrnpsdl swsscsrddl
      481 enflkskvst cllvtdprsq htvrlphklp gmhysaneqc qilfgmnatf crnmehlmca
      541 glwclvegdt scktkldppl dgtecgadkw cragecvskt pipehvdgdw spwgawsmcs
      601 rtcgtgarfr qrkcdnpppg pggthcpgas vehavcenlp cpkglpsfrd qqcqahdrls
      661 pkkkglltav vvddkpcely csplgkespl lvadrvldgt pcgpyetdlc vhgkcqqapi
      721 nqeshh
//
LOCUS       XP_047288169             684 aa            linear   PRI 05-AUG-2025
DEFINITION  A disintegrin and metalloproteinase with thrombospondin motifs 17
            isoform X10 [Homo sapiens].
ACCESSION   XP_047288169
VERSION     XP_047288169.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432213.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..684
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..684
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 17 isoform X10"
                     /calculated_mol_wt=75251
     Region          <81..180
                     /region_name="Pep_M12B_propep"
                     /note="Reprolysin family propeptide; pfam01562"
                     /db_xref="CDD:460254"
     Region          232..493
                     /region_name="ZnMc_ADAMTS_like"
                     /note="Zinc-dependent metalloprotease, ADAMTS_like
                     subgroup. ADAMs (A Disintegrin And Metalloprotease) are
                     glycoproteins, which play roles in cell signaling, cell
                     fusion, and cell-cell interactions. This particular
                     subfamily represents domain architectures that...;
                     cd04273"
                     /db_xref="CDD:239801"
     Site            order(433..434,437,443)
                     /site_type="active"
                     /db_xref="CDD:239801"
     Region          510..577
                     /region_name="ADAMTS_CR_2"
                     /note="ADAMTS cysteine-rich domain 2; pfam17771"
                     /db_xref="CDD:465496"
     Region          590..642
                     /region_name="TSP1"
                     /note="Thrombospondin type 1 repeats; smart00209"
                     /db_xref="CDD:214559"
     CDS             1..684
                     /gene="ADAMTS17"
                     /gene_synonym="WMS4"
                     /coded_by="XM_047432213.1:77..2131"
                     /db_xref="GeneID:170691"
                     /db_xref="HGNC:HGNC:17109"
                     /db_xref="MIM:607511"
ORIGIN      
        1 mcdgallppl vlpvllllvw gldpgtavgd aaadvevvlp wrvrpddvhl pplpaapgpr
       61 rrrrprtppa aprarpgera lllhlpafgr dlylqlrrdl rflsrgfeve eagaarrrgr
      121 paelcfysgr vlghpgslvs lsacgaaggl vgliqlgqeq vliqplnnsq gpfsgrehli
      181 rrkwsltpsp saeaqrpeql ckvltekkkp twgrpsrdwr errnairlts ehtvetlvva
      241 dadmvqyhga eaaqrfiltv mnmvynmfqh qslgikiniq vtklvllrqr paklsighhg
      301 erslesfchw qneeyggary lgnnqvpggk ddpplvdaav fvtrtdfcvh kdepcdtvvp
      361 papfdvregp gsppwwclgr elpeangsqr vipdhsiskt wegiaylggv csakrkcvla
      421 ednglnlaft iahelghnlg mnhdddhssc agrshimsge wvkgrnpsdl swsscsrddl
      481 enflkskvst cllvtdprsq htvrlphklp gmhysaneqc qilfgmnatf crnmehlmca
      541 glwclvegdt scktkldppl dgtecgadkw cragecvskt pipehvdgdw spwgawsmcs
      601 rtcgtgarfr qrkcdnpppg pggthcpgas vehavcenlp cpkglpsfrd qqcqahdrls
      661 pkkkglltav vvdgnktlcy nddi
//
LOCUS       XP_016877471             652 aa            linear   PRI 05-AUG-2025
DEFINITION  A disintegrin and metalloproteinase with thrombospondin motifs 17
            isoform X11 [Homo sapiens].
ACCESSION   XP_016877471
VERSION     XP_016877471.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021982.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..652
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..652
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 17 isoform X11"
                     /calculated_mol_wt=71744
     Region          <1..40
                     /region_name="ADAMTS_CR_2"
                     /note="ADAMTS cysteine-rich domain 2; pfam17771"
                     /db_xref="CDD:465496"
     Region          53..105
                     /region_name="TSP1"
                     /note="Thrombospondin type 1 repeats; smart00209"
                     /db_xref="CDD:214559"
     Region          <137..206
                     /region_name="ADAMTS_CR_3"
                     /note="ADAMTS cysteine-rich domain; pfam19236"
                     /db_xref="CDD:437068"
     Region          244..340
                     /region_name="ADAMTS_spacer1"
                     /note="ADAM-TS Spacer 1; pfam05986"
                     /db_xref="CDD:461796"
     Region          366..418
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          422..478
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          482..524
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          533..580
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     CDS             1..652
                     /gene="ADAMTS17"
                     /gene_synonym="WMS4"
                     /coded_by="XM_017021982.2:163..2121"
                     /db_xref="GeneID:170691"
                     /db_xref="HGNC:HGNC:17109"
                     /db_xref="MIM:607511"
ORIGIN      
        1 mcaglwclve gdtscktkld ppldgtecga dkwcragecv sktpipehvd gdwspwgaws
       61 mcsrtcgtga rfrqrkcdnp ppgpggthcp gasvehavce nlpcpkglps frdqqcqahd
      121 rlspkkkgll tavvvddkpc elycsplgke spllvadrvl dgtpcgpyet dlcvhgkcqk
      181 igcdgiigsa akedrcgvcs gdgktchlvk gdfshargtv kndlctkvst cvmaeavpkc
      241 fscyieaavi pagarrirvv edkpahsfla lkdsgkgsin sdwkielpge fqiagttvry
      301 vrrglwekis akgptklplh lmvllfhdqd ygihyeytvp vnrtaenqse pekpqdslfi
      361 wthsgwegcs vqcgggerrt ivsctrivnk tttlvndsdc pqasrpepqv rrcnlhpcqs
      421 rwvagpwspc satcekgfqh revtcvyqlq ngthvatrpl ycpgprpaav qscegqdcls
      481 iweasewsqc sascgkgvwk rtvactnsqg kcdastrpra eeacedysgc yewktgdwst
      541 csstcgkglq srvvqcmhkv tgrhgsecpa lskpapyrqc yqevcndrin antitsprla
      601 altykctrdq wtvycrvire knlcqdmrwy qrccqtcrdf yankmrqppp ns
//
LOCUS       XP_016877472             580 aa            linear   PRI 05-AUG-2025
DEFINITION  A disintegrin and metalloproteinase with thrombospondin motifs 17
            isoform X12 [Homo sapiens].
ACCESSION   XP_016877472
VERSION     XP_016877472.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021983.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..580
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..580
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 17 isoform X12"
                     /calculated_mol_wt=63885
     Region          <65..134
                     /region_name="ADAMTS_CR_3"
                     /note="ADAMTS cysteine-rich domain; pfam19236"
                     /db_xref="CDD:437068"
     Region          172..268
                     /region_name="ADAMTS_spacer1"
                     /note="ADAM-TS Spacer 1; pfam05986"
                     /db_xref="CDD:461796"
     Region          294..346
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          350..406
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          410..452
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          461..508
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     CDS             1..580
                     /gene="ADAMTS17"
                     /gene_synonym="WMS4"
                     /coded_by="XM_017021983.2:108..1850"
                     /db_xref="GeneID:170691"
                     /db_xref="HGNC:HGNC:17109"
                     /db_xref="MIM:607511"
ORIGIN      
        1 mppsaetwsp gpggthcpga svehavcenl pcpkglpsfr dqqcqahdrl spkkkgllta
       61 vvvddkpcel ycsplgkesp llvadrvldg tpcgpyetdl cvhgkcqkig cdgiigsaak
      121 edrcgvcsgd gktchlvkgd fshargtvkn dlctkvstcv maeavpkcfs cyieaavipa
      181 garrirvved kpahsflalk dsgkgsinsd wkielpgefq iagttvryvr rglwekisak
      241 gptklplhlm vllfhdqdyg ihyeytvpvn rtaenqsepe kpqdslfiwt hsgwegcsvq
      301 cgggerrtiv sctrivnktt tlvndsdcpq asrpepqvrr cnlhpcqsrw vagpwspcsa
      361 tcekgfqhre vtcvyqlqng thvatrplyc pgprpaavqs cegqdclsiw easewsqcsa
      421 scgkgvwkrt vactnsqgkc dastrpraee acedysgcye wktgdwstcs stcgkglqsr
      481 vvqcmhkvtg rhgsecpals kpapyrqcyq evcndrinan titsprlaal tykctrdqwt
      541 vycrvirekn lcqdmrwyqr ccqtcrdfya nkmrqpppns
//
LOCUS       XP_016877473             502 aa            linear   PRI 05-AUG-2025
DEFINITION  A disintegrin and metalloproteinase with thrombospondin motifs 17
            isoform X13 [Homo sapiens].
ACCESSION   XP_016877473
VERSION     XP_016877473.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021984.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..502
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 17 isoform X13"
                     /calculated_mol_wt=54627
     Region          1..206
                     /region_name="ZnMc_ADAMTS_like"
                     /note="Zinc-dependent metalloprotease, ADAMTS_like
                     subgroup. ADAMs (A Disintegrin And Metalloprotease) are
                     glycoproteins, which play roles in cell signaling, cell
                     fusion, and cell-cell interactions. This particular
                     subfamily represents domain architectures that...;
                     cd04273"
                     /db_xref="CDD:239801"
     Site            order(146..147,150,156)
                     /site_type="active"
                     /db_xref="CDD:239801"
     Region          223..290
                     /region_name="ADAMTS_CR_2"
                     /note="ADAMTS cysteine-rich domain 2; pfam17771"
                     /db_xref="CDD:465496"
     Region          303..355
                     /region_name="TSP1"
                     /note="Thrombospondin type 1 repeats; smart00209"
                     /db_xref="CDD:214559"
     Region          <387..456
                     /region_name="ADAMTS_CR_3"
                     /note="ADAMTS cysteine-rich domain; pfam19236"
                     /db_xref="CDD:437068"
     Region          458..>496
                     /region_name="ADAMTS_spacer1"
                     /note="ADAM-TS Spacer 1; pfam05986"
                     /db_xref="CDD:461796"
     CDS             1..502
                     /gene="ADAMTS17"
                     /gene_synonym="WMS4"
                     /coded_by="XM_017021984.2:411..1919"
                     /db_xref="GeneID:170691"
                     /db_xref="HGNC:HGNC:17109"
                     /db_xref="MIM:607511"
ORIGIN      
        1 mvqyhgaeaa qrfiltvmnm vynmfqhqsl gikiniqvtk lvllrqrpak lsighhgers
       61 lesfchwqne eyggarylgn nqvpggkddp plvdaavfvt rtdfcvhkde pcdtvgiayl
      121 ggvcsakrkc vlaednglnl aftiahelgh nlgmnhdddh sscagrshim sgewvkgrnp
      181 sdlswsscsr ddlenflksk vstcllvtdp rsqhtvrlph klpgmhysan eqcqilfgmn
      241 atfcrnmehl mcaglwclve gdtscktkld ppldgtecga dkwcragecv sktpipehvd
      301 gdwspwgaws mcsrtcgtga rfrqrkcdnp ppgpggthcp gasvehavce nlpcpkglps
      361 frdqqcqahd rlspkkkgll tavvvddkpc elycsplgke spllvadrvl dgtpcgpyet
      421 dlcvhgkcqk igcdgiigsa akedrcgvcs gdgktchlvk gdfshargtg yieaavipag
      481 arrirvvedk pahsflgktq mt
//
LOCUS       XP_047288170            2553 aa            linear   PRI 05-AUG-2025
DEFINITION  aggrecan core protein isoform X1 [Homo sapiens].
ACCESSION   XP_047288170
VERSION     XP_047288170.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432214.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2553
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2553
                     /product="aggrecan core protein isoform X1"
                     /calculated_mol_wt=263459
     Region          33..155
                     /region_name="Ig_Aggrecan"
                     /note="Immunoglobulin (Ig)-like domain of the chondroitin
                     sulfate proteoglycan core protein (CSPG), aggrecan;
                     cd05900"
                     /db_xref="CDD:409481"
     Region          33..36
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409481"
     Region          39..41
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409481"
     Region          45..53
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409481"
     Region          72..78
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409481"
     Region          83..86
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409481"
     Region          104..109
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409481"
     Region          115..121
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409481"
     Region          129..136
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409481"
     Region          146..155
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409481"
     Region          153..247
                     /region_name="Link_domain_CSPGs_modules_1_3"
                     /note="this extracellular link domain is found in the
                     first and third link modules of the chondroitin sulfate
                     proteoglycan core protein (CSPG) aggrecan. In addition, it
                     is found in the first link module of three other CSPGs:
                     versican, neurocan, and brevican; cd03517"
                     /db_xref="CDD:239594"
     Site            163..164
                     /site_type="other"
                     /note="putative hyaluronan binding site [chemical
                     binding]"
                     /db_xref="CDD:239594"
     Region          254..349
                     /region_name="Link_domain_CSPGs_modules_2_4"
                     /note="this link domain is found in the second and fourth
                     link modules of the chondroitin sulfate proteoglycan core
                     protein (CSPG) aggrecan and, in the second link module of
                     three other CSPGs: versican, neurocan, and brevican. The
                     link domain is a hyaluronan...; cd03520"
                     /db_xref="CDD:239597"
     Site            261..262
                     /site_type="other"
                     /note="putative hyaluronan binding site [chemical
                     binding]"
                     /db_xref="CDD:239597"
     Region          478..572
                     /region_name="Link_domain_CSPGs_modules_1_3"
                     /note="this extracellular link domain is found in the
                     first and third link modules of the chondroitin sulfate
                     proteoglycan core protein (CSPG) aggrecan. In addition, it
                     is found in the first link module of three other CSPGs:
                     versican, neurocan, and brevican; cd03517"
                     /db_xref="CDD:239594"
     Site            488..489
                     /site_type="other"
                     /note="putative hyaluronan binding site [chemical
                     binding]"
                     /db_xref="CDD:239594"
     Region          579..674
                     /region_name="Link_domain_CSPGs_modules_2_4"
                     /note="this link domain is found in the second and fourth
                     link modules of the chondroitin sulfate proteoglycan core
                     protein (CSPG) aggrecan and, in the second link module of
                     three other CSPGs: versican, neurocan, and brevican. The
                     link domain is a hyaluronan...; cd03520"
                     /db_xref="CDD:239597"
     Site            586..587
                     /site_type="other"
                     /note="putative hyaluronan binding site [chemical
                     binding]"
                     /db_xref="CDD:239597"
     Region          716..>975
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          <1433..>1614
                     /region_name="PRK15387"
                     /note="type III secretion system effector E3 ubiquitin
                     transferase SspH2"
                     /db_xref="CDD:185285"
     Region          1511..2016
                     /region_name="TamB"
                     /note="Autotransporter translocation and assembly protein
                     TamB [Intracellular trafficking, secretion, and vesicular
                     transport]; COG2911"
                     /db_xref="CDD:442155"
     Region          2278..2314
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Site            order(2278,2281,2295)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          2320..2443
                     /region_name="CLECT_CSPGs"
                     /note="C-type lectin-like domain (CTLD) of the type found
                     in chondroitin sulfate proteoglycan core proteins;
                     cd03588"
                     /db_xref="CDD:153058"
     Site            order(2338,2370..2373,2402,2412,2420,2422,2428,2431,
                     2433..2435)
                     /site_type="active"
                     /note="fibronectin type III repeats 3-5 binding site
                     [active]"
                     /db_xref="CDD:153058"
     Site            order(2381,2385,2408,2414..2415)
                     /site_type="other"
                     /note="calcium binding site 1 [ion binding]"
                     /db_xref="CDD:153058"
     Site            order(2385,2415)
                     /site_type="other"
                     /note="calcium binding site 3 [ion binding]"
                     /db_xref="CDD:153058"
     Site            order(2405,2407,2414,2428..2429)
                     /site_type="other"
                     /note="carbohydrate binding site"
                     /db_xref="CDD:153058"
     Region          2447..2503
                     /region_name="CCP"
                     /note="Complement control protein (CCP) modules (aka short
                     consensus repeats SCRs or SUSHI repeats) have been
                     identified in several proteins of the complement system;
                     cd00033"
                     /db_xref="CDD:153056"
     Site            order(2457,2477)
                     /site_type="active"
                     /note="receptor-ligand interactions [active]"
                     /db_xref="CDD:153056"
     CDS             1..2553
                     /gene="ACAN"
                     /gene_synonym="AGC1; AGCAN; CSPG1; CSPGCP; MSK16; SEDK;
                     SSOAOD"
                     /coded_by="XM_047432214.1:382..8043"
                     /db_xref="GeneID:176"
                     /db_xref="HGNC:HGNC:319"
                     /db_xref="MIM:155760"
ORIGIN      
        1 mttllwvfvt lrvitaavtv etsdhdnsls vsipqpsplr vllgtsltip cyfidpmhpv
       61 ttapstapla prikwsrvsk ekevvllvat egrvrvnsay qdkvslpnyp aipsdatlev
      121 qslrsndsgv yrcevmhgie dseatlevvv kgivfhyrai strytldfdr aqraclqnsa
      181 iiatpeqlqa ayedgfhqcd agwladqtvr ypihtpregc ygdkdefpgv rtygirdtne
      241 tydvycfaee megevfyats pekftfqeaa necrrlgarl attgqlylaw qagmdmcsag
      301 wladrsvryp iskarpncgg nllgvrtvyv hanqtgypdp ssrydaicyt gedfvdipen
      361 ffgvggeedi tvqtvtwpdm elplprnite geargsvilt vkpifevsps plepeepftf
      421 apeigatafa evenetgeat rpwgfptpgl gpataftsed lvvqvtavpg qphlpggvvf
      481 hyrpgptrys ltfeeaqqac lrtgaviasp eqlqaayeag yeqcdagwlr dqtvrypivs
      541 prtpcvgdkd sspgvrtygv rpstetydvy cfvdrlegev ffatrleqft fqealefces
      601 hnatlattgq lyaawsrgld kcyagwladg slrypivtpr pacggdkpgv rtvylypnqt
      661 glpdplsrhh afcfrgisav pspgeeeggt ptspsgveew ivtqvvpgva avpveeetta
      721 vpsgettail efttepenqt ewepaytpvg tsplpgilpt wpptgaatee stegpsatev
      781 psaseepsps evpfpseeps pseepfpsvr pfpsvelfps eepfpskeps pseepsasee
      841 pytpsppvps wtelpssgee sgapdvsgdf tgsgdvsghl dfsgqlsgdr asglpsgdld
      901 ssgltstvgs glpvesglps gdeeriewps tptvgelpsg aeilegsasg vgdlsglpsg
      961 evletsasgv gdlsglpsge vlettapgve disglpsgev lettapgved isglpsgevl
     1021 ettapgvedi sglpsgevle ttapgvedis glpsgevlet tapgvedisg lpsgevlett
     1081 apgvedisgl psgevletaa pgvedisglp sgevletaap gvedisglps gevletaapg
     1141 vedisglpsg evletaapgv edisglpsge vletaapgve disglpsgev letaapgved
     1201 isglpsgevl etaapgvedi sglpsgevle taapgvedis glpsgevlet aapgvedisg
     1261 lpsgevleta apgvedisgl psgevletaa pgvedisglp sgevletaap gvedisglps
     1321 gevletaapg vedisglpsg evletaapgv edisglpsge vletaapgve disglpsgev
     1381 letaapgved isglpsgevl ettapgveei sglpsgevle ttapgvdeis glpsgevlet
     1441 tapgveeisg lpsgevlets tsavgdlsgl psggevleis vsgvedisgl psgevvetsa
     1501 sgiedvselp sgegletsas gvedlsrlps geevleisas gfgdlsglps ggegletsas
     1561 evgtdlsglp sgregletsa sgaedlsglp sgkedlvgsa sgdldlgklp sgtlgsgqap
     1621 etsglpsgfs geysgvdlgs gppsglpdfs glpsgfptvs lvdstlvevv tastaseleg
     1681 rgtigisgag eisglpssel disgrasglp sgtelsgqas gspdvsgeip glfgvsgqps
     1741 gfpdtsgets gvtelsglss gqpgisgeas gvlygtsqpf gitdlsgets gvpdlsgqps
     1801 glpgfsgats gvpdlvsgtt sgsgessgit fvdtslveva pttfkeeegl gsvelsglps
     1861 geadlsgksg mvdvsgqfsg tvdssgftsq tpefsglpsg iaevsgessr aeigsslpsg
     1921 ayygsgtpss fptvslvdrt lvesvtqapt aqeagegpsg ilelsgahsg apdmsgehsg
     1981 fldlsglqsg liepsgeppg tpyfsgdfas ttnvsgessv amgtsgeasg lpevtlitse
     2041 fvegvtepti sqelgqrppv thtpqlfess gkvstagdis gatpvlpgsg vevssvpess
     2101 setsaypeag fgasaapeas redsgspdls ettsafhean lerssglgvs gstltfqege
     2161 asaapevsge stttsdvgte apglpsatpt asgdrteisg dlsghtsqlg vvistsipes
     2221 ewtqqtqrpa ethleiesss llysgeetht vetatsptda sipaspewkr esestaadid
     2281 eclsspclng atcvdaidsf tclclpsyeg dlceidqevc eegwnkyqgh cyrhfpdret
     2341 wvdaerrcre qqshlssivt peeqefvnnn aqdyqwigln drtiegdfrw sdghpmqfen
     2401 wrpnqpdnff aagedcvvmi whekgewndv pcnyhlpftc kkgtvacgep pvvehartfg
     2461 qkkdryeins lvryqctegf vqrhmptirc qpsghweepq itctdrehhp ghlaehrvrf
     2521 cqhslppvps pgdptpstgl skgrevggll shk
//
LOCUS       XP_047288171            2553 aa            linear   PRI 05-AUG-2025
DEFINITION  aggrecan core protein isoform X2 [Homo sapiens].
ACCESSION   XP_047288171
VERSION     XP_047288171.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432215.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2553
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2553
                     /product="aggrecan core protein isoform X2"
                     /calculated_mol_wt=263335
     Region          33..155
                     /region_name="Ig_Aggrecan"
                     /note="Immunoglobulin (Ig)-like domain of the chondroitin
                     sulfate proteoglycan core protein (CSPG), aggrecan;
                     cd05900"
                     /db_xref="CDD:409481"
     Region          33..36
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409481"
     Region          39..41
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409481"
     Region          45..53
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409481"
     Region          72..78
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409481"
     Region          83..86
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409481"
     Region          104..109
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409481"
     Region          115..121
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409481"
     Region          129..136
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409481"
     Region          146..155
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409481"
     Region          153..247
                     /region_name="Link_domain_CSPGs_modules_1_3"
                     /note="this extracellular link domain is found in the
                     first and third link modules of the chondroitin sulfate
                     proteoglycan core protein (CSPG) aggrecan. In addition, it
                     is found in the first link module of three other CSPGs:
                     versican, neurocan, and brevican; cd03517"
                     /db_xref="CDD:239594"
     Site            163..164
                     /site_type="other"
                     /note="putative hyaluronan binding site [chemical
                     binding]"
                     /db_xref="CDD:239594"
     Region          254..349
                     /region_name="Link_domain_CSPGs_modules_2_4"
                     /note="this link domain is found in the second and fourth
                     link modules of the chondroitin sulfate proteoglycan core
                     protein (CSPG) aggrecan and, in the second link module of
                     three other CSPGs: versican, neurocan, and brevican. The
                     link domain is a hyaluronan...; cd03520"
                     /db_xref="CDD:239597"
     Site            261..262
                     /site_type="other"
                     /note="putative hyaluronan binding site [chemical
                     binding]"
                     /db_xref="CDD:239597"
     Region          478..572
                     /region_name="Link_domain_CSPGs_modules_1_3"
                     /note="this extracellular link domain is found in the
                     first and third link modules of the chondroitin sulfate
                     proteoglycan core protein (CSPG) aggrecan. In addition, it
                     is found in the first link module of three other CSPGs:
                     versican, neurocan, and brevican; cd03517"
                     /db_xref="CDD:239594"
     Site            488..489
                     /site_type="other"
                     /note="putative hyaluronan binding site [chemical
                     binding]"
                     /db_xref="CDD:239594"
     Region          579..674
                     /region_name="Link_domain_CSPGs_modules_2_4"
                     /note="this link domain is found in the second and fourth
                     link modules of the chondroitin sulfate proteoglycan core
                     protein (CSPG) aggrecan and, in the second link module of
                     three other CSPGs: versican, neurocan, and brevican. The
                     link domain is a hyaluronan...; cd03520"
                     /db_xref="CDD:239597"
     Site            586..587
                     /site_type="other"
                     /note="putative hyaluronan binding site [chemical
                     binding]"
                     /db_xref="CDD:239597"
     Region          716..>975
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          <1433..>1614
                     /region_name="PRK15387"
                     /note="type III secretion system effector E3 ubiquitin
                     transferase SspH2"
                     /db_xref="CDD:185285"
     Region          1511..2016
                     /region_name="TamB"
                     /note="Autotransporter translocation and assembly protein
                     TamB [Intracellular trafficking, secretion, and vesicular
                     transport]; COG2911"
                     /db_xref="CDD:442155"
     Region          2283..2313
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          2320..2443
                     /region_name="CLECT_CSPGs"
                     /note="C-type lectin-like domain (CTLD) of the type found
                     in chondroitin sulfate proteoglycan core proteins;
                     cd03588"
                     /db_xref="CDD:153058"
     Site            order(2338,2370..2373,2402,2412,2420,2422,2428,2431,
                     2433..2435)
                     /site_type="active"
                     /note="fibronectin type III repeats 3-5 binding site
                     [active]"
                     /db_xref="CDD:153058"
     Site            order(2381,2385,2408,2414..2415)
                     /site_type="other"
                     /note="calcium binding site 1 [ion binding]"
                     /db_xref="CDD:153058"
     Site            order(2385,2415)
                     /site_type="other"
                     /note="calcium binding site 3 [ion binding]"
                     /db_xref="CDD:153058"
     Site            order(2405,2407,2414,2428..2429)
                     /site_type="other"
                     /note="carbohydrate binding site"
                     /db_xref="CDD:153058"
     Region          2447..2503
                     /region_name="CCP"
                     /note="Complement control protein (CCP) modules (aka short
                     consensus repeats SCRs or SUSHI repeats) have been
                     identified in several proteins of the complement system;
                     cd00033"
                     /db_xref="CDD:153056"
     Site            order(2457,2477)
                     /site_type="active"
                     /note="receptor-ligand interactions [active]"
                     /db_xref="CDD:153056"
     CDS             1..2553
                     /gene="ACAN"
                     /gene_synonym="AGC1; AGCAN; CSPG1; CSPGCP; MSK16; SEDK;
                     SSOAOD"
                     /coded_by="XM_047432215.1:382..8043"
                     /db_xref="GeneID:176"
                     /db_xref="HGNC:HGNC:319"
                     /db_xref="MIM:155760"
ORIGIN      
        1 mttllwvfvt lrvitaavtv etsdhdnsls vsipqpsplr vllgtsltip cyfidpmhpv
       61 ttapstapla prikwsrvsk ekevvllvat egrvrvnsay qdkvslpnyp aipsdatlev
      121 qslrsndsgv yrcevmhgie dseatlevvv kgivfhyrai strytldfdr aqraclqnsa
      181 iiatpeqlqa ayedgfhqcd agwladqtvr ypihtpregc ygdkdefpgv rtygirdtne
      241 tydvycfaee megevfyats pekftfqeaa necrrlgarl attgqlylaw qagmdmcsag
      301 wladrsvryp iskarpncgg nllgvrtvyv hanqtgypdp ssrydaicyt gedfvdipen
      361 ffgvggeedi tvqtvtwpdm elplprnite geargsvilt vkpifevsps plepeepftf
      421 apeigatafa evenetgeat rpwgfptpgl gpataftsed lvvqvtavpg qphlpggvvf
      481 hyrpgptrys ltfeeaqqac lrtgaviasp eqlqaayeag yeqcdagwlr dqtvrypivs
      541 prtpcvgdkd sspgvrtygv rpstetydvy cfvdrlegev ffatrleqft fqealefces
      601 hnatlattgq lyaawsrgld kcyagwladg slrypivtpr pacggdkpgv rtvylypnqt
      661 glpdplsrhh afcfrgisav pspgeeeggt ptspsgveew ivtqvvpgva avpveeetta
      721 vpsgettail efttepenqt ewepaytpvg tsplpgilpt wpptgaatee stegpsatev
      781 psaseepsps evpfpseeps pseepfpsvr pfpsvelfps eepfpskeps pseepsasee
      841 pytpsppvps wtelpssgee sgapdvsgdf tgsgdvsghl dfsgqlsgdr asglpsgdld
      901 ssgltstvgs glpvesglps gdeeriewps tptvgelpsg aeilegsasg vgdlsglpsg
      961 evletsasgv gdlsglpsge vlettapgve disglpsgev lettapgved isglpsgevl
     1021 ettapgvedi sglpsgevle ttapgvedis glpsgevlet tapgvedisg lpsgevlett
     1081 apgvedisgl psgevletaa pgvedisglp sgevletaap gvedisglps gevletaapg
     1141 vedisglpsg evletaapgv edisglpsge vletaapgve disglpsgev letaapgved
     1201 isglpsgevl etaapgvedi sglpsgevle taapgvedis glpsgevlet aapgvedisg
     1261 lpsgevleta apgvedisgl psgevletaa pgvedisglp sgevletaap gvedisglps
     1321 gevletaapg vedisglpsg evletaapgv edisglpsge vletaapgve disglpsgev
     1381 letaapgved isglpsgevl ettapgveei sglpsgevle ttapgvdeis glpsgevlet
     1441 tapgveeisg lpsgevlets tsavgdlsgl psggevleis vsgvedisgl psgevvetsa
     1501 sgiedvselp sgegletsas gvedlsrlps geevleisas gfgdlsglps ggegletsas
     1561 evgtdlsglp sgregletsa sgaedlsglp sgkedlvgsa sgdldlgklp sgtlgsgqap
     1621 etsglpsgfs geysgvdlgs gppsglpdfs glpsgfptvs lvdstlvevv tastaseleg
     1681 rgtigisgag eisglpssel disgrasglp sgtelsgqas gspdvsgeip glfgvsgqps
     1741 gfpdtsgets gvtelsglss gqpgisgeas gvlygtsqpf gitdlsgets gvpdlsgqps
     1801 glpgfsgats gvpdlvsgtt sgsgessgit fvdtslveva pttfkeeegl gsvelsglps
     1861 geadlsgksg mvdvsgqfsg tvdssgftsq tpefsglpsg iaevsgessr aeigsslpsg
     1921 ayygsgtpss fptvslvdrt lvesvtqapt aqeagegpsg ilelsgahsg apdmsgehsg
     1981 fldlsglqsg liepsgeppg tpyfsgdfas ttnvsgessv amgtsgeasg lpevtlitse
     2041 fvegvtepti sqelgqrppv thtpqlfess gkvstagdis gatpvlpgsg vevssvpess
     2101 setsaypeag fgasaapeas redsgspdls ettsafhean lerssglgvs gstltfqege
     2161 asaapevsge stttsdvgte apglpsatpt asgdrteisg dlsghtsqlg vvistsipes
     2221 ewtqqtqrpa ethleiesss llysgeetht vetatsptda sipaspewkr esestaaapa
     2281 rscaeepcga gtcketeghv iclcppgytg ehcnidqevc eegwnkyqgh cyrhfpdret
     2341 wvdaerrcre qqshlssivt peeqefvnnn aqdyqwigln drtiegdfrw sdghpmqfen
     2401 wrpnqpdnff aagedcvvmi whekgewndv pcnyhlpftc kkgtvacgep pvvehartfg
     2461 qkkdryeins lvryqctegf vqrhmptirc qpsghweepq itctdrehhp ghlaehrvrf
     2521 cqhslppvps pgdptpstgl skgrevggll shk
//
LOCUS       XP_047288172            2515 aa            linear   PRI 05-AUG-2025
DEFINITION  aggrecan core protein isoform X3 [Homo sapiens].
ACCESSION   XP_047288172
VERSION     XP_047288172.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432216.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2515
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2515
                     /product="aggrecan core protein isoform X3"
                     /calculated_mol_wt=259447
     Region          33..155
                     /region_name="Ig_Aggrecan"
                     /note="Immunoglobulin (Ig)-like domain of the chondroitin
                     sulfate proteoglycan core protein (CSPG), aggrecan;
                     cd05900"
                     /db_xref="CDD:409481"
     Region          33..36
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409481"
     Region          39..41
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409481"
     Region          45..53
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409481"
     Region          72..78
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409481"
     Region          83..86
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409481"
     Region          104..109
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409481"
     Region          115..121
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409481"
     Region          129..136
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409481"
     Region          146..155
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409481"
     Region          153..247
                     /region_name="Link_domain_CSPGs_modules_1_3"
                     /note="this extracellular link domain is found in the
                     first and third link modules of the chondroitin sulfate
                     proteoglycan core protein (CSPG) aggrecan. In addition, it
                     is found in the first link module of three other CSPGs:
                     versican, neurocan, and brevican; cd03517"
                     /db_xref="CDD:239594"
     Site            163..164
                     /site_type="other"
                     /note="putative hyaluronan binding site [chemical
                     binding]"
                     /db_xref="CDD:239594"
     Region          254..349
                     /region_name="Link_domain_CSPGs_modules_2_4"
                     /note="this link domain is found in the second and fourth
                     link modules of the chondroitin sulfate proteoglycan core
                     protein (CSPG) aggrecan and, in the second link module of
                     three other CSPGs: versican, neurocan, and brevican. The
                     link domain is a hyaluronan...; cd03520"
                     /db_xref="CDD:239597"
     Site            261..262
                     /site_type="other"
                     /note="putative hyaluronan binding site [chemical
                     binding]"
                     /db_xref="CDD:239597"
     Region          478..572
                     /region_name="Link_domain_CSPGs_modules_1_3"
                     /note="this extracellular link domain is found in the
                     first and third link modules of the chondroitin sulfate
                     proteoglycan core protein (CSPG) aggrecan. In addition, it
                     is found in the first link module of three other CSPGs:
                     versican, neurocan, and brevican; cd03517"
                     /db_xref="CDD:239594"
     Site            488..489
                     /site_type="other"
                     /note="putative hyaluronan binding site [chemical
                     binding]"
                     /db_xref="CDD:239594"
     Region          579..674
                     /region_name="Link_domain_CSPGs_modules_2_4"
                     /note="this link domain is found in the second and fourth
                     link modules of the chondroitin sulfate proteoglycan core
                     protein (CSPG) aggrecan and, in the second link module of
                     three other CSPGs: versican, neurocan, and brevican. The
                     link domain is a hyaluronan...; cd03520"
                     /db_xref="CDD:239597"
     Site            586..587
                     /site_type="other"
                     /note="putative hyaluronan binding site [chemical
                     binding]"
                     /db_xref="CDD:239597"
     Region          716..>975
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          <1433..>1614
                     /region_name="PRK15387"
                     /note="type III secretion system effector E3 ubiquitin
                     transferase SspH2"
                     /db_xref="CDD:185285"
     Region          1511..2016
                     /region_name="TamB"
                     /note="Autotransporter translocation and assembly protein
                     TamB [Intracellular trafficking, secretion, and vesicular
                     transport]; COG2911"
                     /db_xref="CDD:442155"
     Region          2115..>2403
                     /region_name="PCC"
                     /note="polycystin cation channel protein; TIGR00864"
                     /db_xref="CDD:188093"
     Region          2282..2405
                     /region_name="CLECT_CSPGs"
                     /note="C-type lectin-like domain (CTLD) of the type found
                     in chondroitin sulfate proteoglycan core proteins;
                     cd03588"
                     /db_xref="CDD:153058"
     Site            order(2300,2332..2335,2364,2374,2382,2384,2390,2393,
                     2395..2397)
                     /site_type="active"
                     /note="fibronectin type III repeats 3-5 binding site
                     [active]"
                     /db_xref="CDD:153058"
     Site            order(2343,2347,2370,2376..2377)
                     /site_type="other"
                     /note="calcium binding site 1 [ion binding]"
                     /db_xref="CDD:153058"
     Site            order(2347,2377)
                     /site_type="other"
                     /note="calcium binding site 3 [ion binding]"
                     /db_xref="CDD:153058"
     Site            order(2367,2369,2376,2390..2391)
                     /site_type="other"
                     /note="carbohydrate binding site"
                     /db_xref="CDD:153058"
     Region          2409..2465
                     /region_name="CCP"
                     /note="Complement control protein (CCP) modules (aka short
                     consensus repeats SCRs or SUSHI repeats) have been
                     identified in several proteins of the complement system;
                     cd00033"
                     /db_xref="CDD:153056"
     Site            order(2419,2439)
                     /site_type="active"
                     /note="receptor-ligand interactions [active]"
                     /db_xref="CDD:153056"
     CDS             1..2515
                     /gene="ACAN"
                     /gene_synonym="AGC1; AGCAN; CSPG1; CSPGCP; MSK16; SEDK;
                     SSOAOD"
                     /coded_by="XM_047432216.1:580..8127"
                     /db_xref="GeneID:176"
                     /db_xref="HGNC:HGNC:319"
                     /db_xref="MIM:155760"
ORIGIN      
        1 mttllwvfvt lrvitaavtv etsdhdnsls vsipqpsplr vllgtsltip cyfidpmhpv
       61 ttapstapla prikwsrvsk ekevvllvat egrvrvnsay qdkvslpnyp aipsdatlev
      121 qslrsndsgv yrcevmhgie dseatlevvv kgivfhyrai strytldfdr aqraclqnsa
      181 iiatpeqlqa ayedgfhqcd agwladqtvr ypihtpregc ygdkdefpgv rtygirdtne
      241 tydvycfaee megevfyats pekftfqeaa necrrlgarl attgqlylaw qagmdmcsag
      301 wladrsvryp iskarpncgg nllgvrtvyv hanqtgypdp ssrydaicyt gedfvdipen
      361 ffgvggeedi tvqtvtwpdm elplprnite geargsvilt vkpifevsps plepeepftf
      421 apeigatafa evenetgeat rpwgfptpgl gpataftsed lvvqvtavpg qphlpggvvf
      481 hyrpgptrys ltfeeaqqac lrtgaviasp eqlqaayeag yeqcdagwlr dqtvrypivs
      541 prtpcvgdkd sspgvrtygv rpstetydvy cfvdrlegev ffatrleqft fqealefces
      601 hnatlattgq lyaawsrgld kcyagwladg slrypivtpr pacggdkpgv rtvylypnqt
      661 glpdplsrhh afcfrgisav pspgeeeggt ptspsgveew ivtqvvpgva avpveeetta
      721 vpsgettail efttepenqt ewepaytpvg tsplpgilpt wpptgaatee stegpsatev
      781 psaseepsps evpfpseeps pseepfpsvr pfpsvelfps eepfpskeps pseepsasee
      841 pytpsppvps wtelpssgee sgapdvsgdf tgsgdvsghl dfsgqlsgdr asglpsgdld
      901 ssgltstvgs glpvesglps gdeeriewps tptvgelpsg aeilegsasg vgdlsglpsg
      961 evletsasgv gdlsglpsge vlettapgve disglpsgev lettapgved isglpsgevl
     1021 ettapgvedi sglpsgevle ttapgvedis glpsgevlet tapgvedisg lpsgevlett
     1081 apgvedisgl psgevletaa pgvedisglp sgevletaap gvedisglps gevletaapg
     1141 vedisglpsg evletaapgv edisglpsge vletaapgve disglpsgev letaapgved
     1201 isglpsgevl etaapgvedi sglpsgevle taapgvedis glpsgevlet aapgvedisg
     1261 lpsgevleta apgvedisgl psgevletaa pgvedisglp sgevletaap gvedisglps
     1321 gevletaapg vedisglpsg evletaapgv edisglpsge vletaapgve disglpsgev
     1381 letaapgved isglpsgevl ettapgveei sglpsgevle ttapgvdeis glpsgevlet
     1441 tapgveeisg lpsgevlets tsavgdlsgl psggevleis vsgvedisgl psgevvetsa
     1501 sgiedvselp sgegletsas gvedlsrlps geevleisas gfgdlsglps ggegletsas
     1561 evgtdlsglp sgregletsa sgaedlsglp sgkedlvgsa sgdldlgklp sgtlgsgqap
     1621 etsglpsgfs geysgvdlgs gppsglpdfs glpsgfptvs lvdstlvevv tastaseleg
     1681 rgtigisgag eisglpssel disgrasglp sgtelsgqas gspdvsgeip glfgvsgqps
     1741 gfpdtsgets gvtelsglss gqpgisgeas gvlygtsqpf gitdlsgets gvpdlsgqps
     1801 glpgfsgats gvpdlvsgtt sgsgessgit fvdtslveva pttfkeeegl gsvelsglps
     1861 geadlsgksg mvdvsgqfsg tvdssgftsq tpefsglpsg iaevsgessr aeigsslpsg
     1921 ayygsgtpss fptvslvdrt lvesvtqapt aqeagegpsg ilelsgahsg apdmsgehsg
     1981 fldlsglqsg liepsgeppg tpyfsgdfas ttnvsgessv amgtsgeasg lpevtlitse
     2041 fvegvtepti sqelgqrppv thtpqlfess gkvstagdis gatpvlpgsg vevssvpess
     2101 setsaypeag fgasaapeas redsgspdls ettsafhean lerssglgvs gstltfqege
     2161 asaapevsge stttsdvgte apglpsatpt asgdrteisg dlsghtsqlg vvistsipes
     2221 ewtqqtqrpa ethleiesss llysgeetht vetatsptda sipaspewkr esestaadqe
     2281 vceegwnkyq ghcyrhfpdr etwvdaerrc reqqshlssi vtpeeqefvn nnaqdyqwig
     2341 lndrtiegdf rwsdghpmqf enwrpnqpdn ffaagedcvv miwhekgewn dvpcnyhlpf
     2401 tckkgtvacg eppvvehart fgqkkdryei nslvryqcte gfvqrhmpti rcqpsghwee
     2461 pqitctdreh hpghlaehrv rfcqhslppv pspgdptpst glskgrevgg llshk
//
LOCUS       XP_047288173            2515 aa            linear   PRI 05-AUG-2025
DEFINITION  aggrecan core protein isoform X3 [Homo sapiens].
ACCESSION   XP_047288173
VERSION     XP_047288173.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432217.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2515
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2515
                     /product="aggrecan core protein isoform X3"
                     /calculated_mol_wt=259447
     Region          33..155
                     /region_name="Ig_Aggrecan"
                     /note="Immunoglobulin (Ig)-like domain of the chondroitin
                     sulfate proteoglycan core protein (CSPG), aggrecan;
                     cd05900"
                     /db_xref="CDD:409481"
     Region          33..36
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409481"
     Region          39..41
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409481"
     Region          45..53
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409481"
     Region          72..78
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409481"
     Region          83..86
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409481"
     Region          104..109
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409481"
     Region          115..121
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409481"
     Region          129..136
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409481"
     Region          146..155
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409481"
     Region          153..247
                     /region_name="Link_domain_CSPGs_modules_1_3"
                     /note="this extracellular link domain is found in the
                     first and third link modules of the chondroitin sulfate
                     proteoglycan core protein (CSPG) aggrecan. In addition, it
                     is found in the first link module of three other CSPGs:
                     versican, neurocan, and brevican; cd03517"
                     /db_xref="CDD:239594"
     Site            163..164
                     /site_type="other"
                     /note="putative hyaluronan binding site [chemical
                     binding]"
                     /db_xref="CDD:239594"
     Region          254..349
                     /region_name="Link_domain_CSPGs_modules_2_4"
                     /note="this link domain is found in the second and fourth
                     link modules of the chondroitin sulfate proteoglycan core
                     protein (CSPG) aggrecan and, in the second link module of
                     three other CSPGs: versican, neurocan, and brevican. The
                     link domain is a hyaluronan...; cd03520"
                     /db_xref="CDD:239597"
     Site            261..262
                     /site_type="other"
                     /note="putative hyaluronan binding site [chemical
                     binding]"
                     /db_xref="CDD:239597"
     Region          478..572
                     /region_name="Link_domain_CSPGs_modules_1_3"
                     /note="this extracellular link domain is found in the
                     first and third link modules of the chondroitin sulfate
                     proteoglycan core protein (CSPG) aggrecan. In addition, it
                     is found in the first link module of three other CSPGs:
                     versican, neurocan, and brevican; cd03517"
                     /db_xref="CDD:239594"
     Site            488..489
                     /site_type="other"
                     /note="putative hyaluronan binding site [chemical
                     binding]"
                     /db_xref="CDD:239594"
     Region          579..674
                     /region_name="Link_domain_CSPGs_modules_2_4"
                     /note="this link domain is found in the second and fourth
                     link modules of the chondroitin sulfate proteoglycan core
                     protein (CSPG) aggrecan and, in the second link module of
                     three other CSPGs: versican, neurocan, and brevican. The
                     link domain is a hyaluronan...; cd03520"
                     /db_xref="CDD:239597"
     Site            586..587
                     /site_type="other"
                     /note="putative hyaluronan binding site [chemical
                     binding]"
                     /db_xref="CDD:239597"
     Region          716..>975
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          <1433..>1614
                     /region_name="PRK15387"
                     /note="type III secretion system effector E3 ubiquitin
                     transferase SspH2"
                     /db_xref="CDD:185285"
     Region          1511..2016
                     /region_name="TamB"
                     /note="Autotransporter translocation and assembly protein
                     TamB [Intracellular trafficking, secretion, and vesicular
                     transport]; COG2911"
                     /db_xref="CDD:442155"
     Region          2115..>2403
                     /region_name="PCC"
                     /note="polycystin cation channel protein; TIGR00864"
                     /db_xref="CDD:188093"
     Region          2282..2405
                     /region_name="CLECT_CSPGs"
                     /note="C-type lectin-like domain (CTLD) of the type found
                     in chondroitin sulfate proteoglycan core proteins;
                     cd03588"
                     /db_xref="CDD:153058"
     Site            order(2300,2332..2335,2364,2374,2382,2384,2390,2393,
                     2395..2397)
                     /site_type="active"
                     /note="fibronectin type III repeats 3-5 binding site
                     [active]"
                     /db_xref="CDD:153058"
     Site            order(2343,2347,2370,2376..2377)
                     /site_type="other"
                     /note="calcium binding site 1 [ion binding]"
                     /db_xref="CDD:153058"
     Site            order(2347,2377)
                     /site_type="other"
                     /note="calcium binding site 3 [ion binding]"
                     /db_xref="CDD:153058"
     Site            order(2367,2369,2376,2390..2391)
                     /site_type="other"
                     /note="carbohydrate binding site"
                     /db_xref="CDD:153058"
     Region          2409..2465
                     /region_name="CCP"
                     /note="Complement control protein (CCP) modules (aka short
                     consensus repeats SCRs or SUSHI repeats) have been
                     identified in several proteins of the complement system;
                     cd00033"
                     /db_xref="CDD:153056"
     Site            order(2419,2439)
                     /site_type="active"
                     /note="receptor-ligand interactions [active]"
                     /db_xref="CDD:153056"
     CDS             1..2515
                     /gene="ACAN"
                     /gene_synonym="AGC1; AGCAN; CSPG1; CSPGCP; MSK16; SEDK;
                     SSOAOD"
                     /coded_by="XM_047432217.1:382..7929"
                     /db_xref="GeneID:176"
                     /db_xref="HGNC:HGNC:319"
                     /db_xref="MIM:155760"
ORIGIN      
        1 mttllwvfvt lrvitaavtv etsdhdnsls vsipqpsplr vllgtsltip cyfidpmhpv
       61 ttapstapla prikwsrvsk ekevvllvat egrvrvnsay qdkvslpnyp aipsdatlev
      121 qslrsndsgv yrcevmhgie dseatlevvv kgivfhyrai strytldfdr aqraclqnsa
      181 iiatpeqlqa ayedgfhqcd agwladqtvr ypihtpregc ygdkdefpgv rtygirdtne
      241 tydvycfaee megevfyats pekftfqeaa necrrlgarl attgqlylaw qagmdmcsag
      301 wladrsvryp iskarpncgg nllgvrtvyv hanqtgypdp ssrydaicyt gedfvdipen
      361 ffgvggeedi tvqtvtwpdm elplprnite geargsvilt vkpifevsps plepeepftf
      421 apeigatafa evenetgeat rpwgfptpgl gpataftsed lvvqvtavpg qphlpggvvf
      481 hyrpgptrys ltfeeaqqac lrtgaviasp eqlqaayeag yeqcdagwlr dqtvrypivs
      541 prtpcvgdkd sspgvrtygv rpstetydvy cfvdrlegev ffatrleqft fqealefces
      601 hnatlattgq lyaawsrgld kcyagwladg slrypivtpr pacggdkpgv rtvylypnqt
      661 glpdplsrhh afcfrgisav pspgeeeggt ptspsgveew ivtqvvpgva avpveeetta
      721 vpsgettail efttepenqt ewepaytpvg tsplpgilpt wpptgaatee stegpsatev
      781 psaseepsps evpfpseeps pseepfpsvr pfpsvelfps eepfpskeps pseepsasee
      841 pytpsppvps wtelpssgee sgapdvsgdf tgsgdvsghl dfsgqlsgdr asglpsgdld
      901 ssgltstvgs glpvesglps gdeeriewps tptvgelpsg aeilegsasg vgdlsglpsg
      961 evletsasgv gdlsglpsge vlettapgve disglpsgev lettapgved isglpsgevl
     1021 ettapgvedi sglpsgevle ttapgvedis glpsgevlet tapgvedisg lpsgevlett
     1081 apgvedisgl psgevletaa pgvedisglp sgevletaap gvedisglps gevletaapg
     1141 vedisglpsg evletaapgv edisglpsge vletaapgve disglpsgev letaapgved
     1201 isglpsgevl etaapgvedi sglpsgevle taapgvedis glpsgevlet aapgvedisg
     1261 lpsgevleta apgvedisgl psgevletaa pgvedisglp sgevletaap gvedisglps
     1321 gevletaapg vedisglpsg evletaapgv edisglpsge vletaapgve disglpsgev
     1381 letaapgved isglpsgevl ettapgveei sglpsgevle ttapgvdeis glpsgevlet
     1441 tapgveeisg lpsgevlets tsavgdlsgl psggevleis vsgvedisgl psgevvetsa
     1501 sgiedvselp sgegletsas gvedlsrlps geevleisas gfgdlsglps ggegletsas
     1561 evgtdlsglp sgregletsa sgaedlsglp sgkedlvgsa sgdldlgklp sgtlgsgqap
     1621 etsglpsgfs geysgvdlgs gppsglpdfs glpsgfptvs lvdstlvevv tastaseleg
     1681 rgtigisgag eisglpssel disgrasglp sgtelsgqas gspdvsgeip glfgvsgqps
     1741 gfpdtsgets gvtelsglss gqpgisgeas gvlygtsqpf gitdlsgets gvpdlsgqps
     1801 glpgfsgats gvpdlvsgtt sgsgessgit fvdtslveva pttfkeeegl gsvelsglps
     1861 geadlsgksg mvdvsgqfsg tvdssgftsq tpefsglpsg iaevsgessr aeigsslpsg
     1921 ayygsgtpss fptvslvdrt lvesvtqapt aqeagegpsg ilelsgahsg apdmsgehsg
     1981 fldlsglqsg liepsgeppg tpyfsgdfas ttnvsgessv amgtsgeasg lpevtlitse
     2041 fvegvtepti sqelgqrppv thtpqlfess gkvstagdis gatpvlpgsg vevssvpess
     2101 setsaypeag fgasaapeas redsgspdls ettsafhean lerssglgvs gstltfqege
     2161 asaapevsge stttsdvgte apglpsatpt asgdrteisg dlsghtsqlg vvistsipes
     2221 ewtqqtqrpa ethleiesss llysgeetht vetatsptda sipaspewkr esestaadqe
     2281 vceegwnkyq ghcyrhfpdr etwvdaerrc reqqshlssi vtpeeqefvn nnaqdyqwig
     2341 lndrtiegdf rwsdghpmqf enwrpnqpdn ffaagedcvv miwhekgewn dvpcnyhlpf
     2401 tckkgtvacg eppvvehart fgqkkdryei nslvryqcte gfvqrhmpti rcqpsghwee
     2461 pqitctdreh hpghlaehrv rfcqhslppv pspgdptpst glskgrevgg llshk
//
LOCUS       XP_047288174             273 aa            linear   PRI 05-AUG-2025
DEFINITION  secretory carrier-associated membrane protein 5 isoform X1 [Homo
            sapiens].
ACCESSION   XP_047288174
VERSION     XP_047288174.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432218.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..273
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..273
                     /product="secretory carrier-associated membrane protein 5
                     isoform X1"
                     /calculated_mol_wt=29967
     Region          44..217
                     /region_name="SCAMP"
                     /note="SCAMP family; pfam04144"
                     /db_xref="CDD:461193"
     CDS             1..273
                     /gene="SCAMP5"
                     /coded_by="XM_047432218.1:164..985"
                     /db_xref="GeneID:192683"
                     /db_xref="HGNC:HGNC:30386"
                     /db_xref="MIM:613766"
ORIGIN      
        1 mpprpeprpr tdagppvaap srfrtkrcgq atgpagnima ekvnnfpplp kfiplkpcfy
       61 qdfeadippq hvsmtkrlyy lwmlnsvtla vnlvgclawl iggggatnfg laflwlilft
      121 pcsyvcwfrp iykafktdss fsfmaffftf maqlvisiiq avgipgwgvc gwiatisffg
      181 tnigsavvml iptvmftvma vfsfialsmv hkfyrgsggs fskaqeewtt gawknphvqq
      241 aaqnaamgaa qgamnqpqtq ysatpnytys nem
//
LOCUS       XP_006720483             253 aa            linear   PRI 05-AUG-2025
DEFINITION  secretory carrier-associated membrane protein 5 isoform X2 [Homo
            sapiens].
ACCESSION   XP_006720483
VERSION     XP_006720483.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720420.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..253
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..253
                     /product="secretory carrier-associated membrane protein 5
                     isoform X2"
                     /calculated_mol_wt=27893
     Region          24..197
                     /region_name="SCAMP"
                     /note="SCAMP family; pfam04144"
                     /db_xref="CDD:461193"
     CDS             1..253
                     /gene="SCAMP5"
                     /coded_by="XM_006720420.2:294..1055"
                     /db_xref="GeneID:192683"
                     /db_xref="HGNC:HGNC:30386"
                     /db_xref="MIM:613766"
ORIGIN      
        1 mefrtkrcgq atgpagnima ekvnnfpplp kfiplkpcfy qdfeadippq hvsmtkrlyy
       61 lwmlnsvtla vnlvgclawl iggggatnfg laflwlilft pcsyvcwfrp iykafktdss
      121 fsfmaffftf maqlvisiiq avgipgwgvc gwiatisffg tnigsavvml iptvmftvma
      181 vfsfialsmv hkfyrgsggs fskaqeewtt gawknphvqq aaqnaamgaa qgamnqpqtq
      241 ysatpnytys nem
//
LOCUS       XP_006720484             235 aa            linear   PRI 05-AUG-2025
DEFINITION  secretory carrier-associated membrane protein 5 isoform X3 [Homo
            sapiens].
ACCESSION   XP_006720484
VERSION     XP_006720484.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720421.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..235
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..235
                     /product="secretory carrier-associated membrane protein 5
                     isoform X3"
                     /calculated_mol_wt=25973
     Region          6..179
                     /region_name="SCAMP"
                     /note="SCAMP family; pfam04144"
                     /db_xref="CDD:461193"
     CDS             1..235
                     /gene="SCAMP5"
                     /coded_by="XM_006720421.2:228..935"
                     /db_xref="GeneID:192683"
                     /db_xref="HGNC:HGNC:30386"
                     /db_xref="MIM:613766"
ORIGIN      
        1 maekvnnfpp lpkfiplkpc fyqdfeadip pqhvsmtkrl yylwmlnsvt lavnlvgcla
       61 wliggggatn fglaflwlil ftpcsyvcwf rpiykafktd ssfsfmafff tfmaqlvisi
      121 iqavgipgwg vcgwiatisf fgtnigsavv mliptvmftv mavfsfials mvhkfyrgsg
      181 gsfskaqeew ttgawknphv qqaaqnaamg aaqgamnqpq tqysatpnyt ysnem
//
LOCUS       XP_047288175             235 aa            linear   PRI 05-AUG-2025
DEFINITION  secretory carrier-associated membrane protein 5 isoform X3 [Homo
            sapiens].
ACCESSION   XP_047288175
VERSION     XP_047288175.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432219.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..235
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..235
                     /product="secretory carrier-associated membrane protein 5
                     isoform X3"
                     /calculated_mol_wt=25973
     Region          6..179
                     /region_name="SCAMP"
                     /note="SCAMP family; pfam04144"
                     /db_xref="CDD:461193"
     CDS             1..235
                     /gene="SCAMP5"
                     /coded_by="XM_047432219.1:70..777"
                     /db_xref="GeneID:192683"
                     /db_xref="HGNC:HGNC:30386"
                     /db_xref="MIM:613766"
ORIGIN      
        1 maekvnnfpp lpkfiplkpc fyqdfeadip pqhvsmtkrl yylwmlnsvt lavnlvgcla
       61 wliggggatn fglaflwlil ftpcsyvcwf rpiykafktd ssfsfmafff tfmaqlvisi
      121 iqavgipgwg vcgwiatisf fgtnigsavv mliptvmftv mavfsfials mvhkfyrgsg
      181 gsfskaqeew ttgawknphv qqaaqnaamg aaqgamnqpq tqysatpnyt ysnem
//
LOCUS       XP_005254271             533 aa            linear   PRI 05-AUG-2025
DEFINITION  protein FAM227B isoform X1 [Homo sapiens].
ACCESSION   XP_005254271
VERSION     XP_005254271.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254214.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..533
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..533
                     /product="protein FAM227B isoform X1"
                     /calculated_mol_wt=62990
     Region          159..304
                     /region_name="FWWh"
                     /note="Protein of unknown function; pfam14922"
                     /db_xref="CDD:464378"
     Region          <423..489
                     /region_name="HOATZ-like"
                     /note="Cilia- and flagella-associated protein HOATZ-like;
                     pfam17664"
                     /db_xref="CDD:465445"
     CDS             1..533
                     /gene="FAM227B"
                     /gene_synonym="C15orf33"
                     /coded_by="XM_005254214.4:192..1793"
                     /db_xref="GeneID:196951"
                     /db_xref="HGNC:HGNC:26543"
ORIGIN      
        1 magqrtcqrr ssragpgkmq eppksieefl kfqnwdywpr eihfrdddkw sctlkkiked
       61 ssfvsiythl wenvprifea llimesklke yslilqnhts eifkwksmis etssyrkler
      121 ygeflkkyhk kkkimlsdem etekniegcs ftgfkanelt qlprhldaeq iylfilkahn
      181 fdervfkiwk thflseasia llhdsfwwwf lhkfrpdren qdclfdrise syvtlfmsip
      241 lsrkdaffqi ypdclaqaiy atfheafpes sylfndefke dlgnniflwc sglkpqkgfw
      301 ihwklkelst ttihgskkap aksvkeriad sqehistsid fniikilnnp raytlpiske
      361 esrlsrlatk shysstgpef nrvlfnfggq splilyylkm helagiskap kktkikltki
      421 fqeplpapty rdvikeakrq farnqkdfrm eklrineeik llkqqqerid keldrlqaka
      481 tkkphevkqd fekflhklrs eaeierecva slsssssssp sstdnynfee eey
//
LOCUS       XP_005254270             533 aa            linear   PRI 05-AUG-2025
DEFINITION  protein FAM227B isoform X1 [Homo sapiens].
ACCESSION   XP_005254270
VERSION     XP_005254270.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254213.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..533
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..533
                     /product="protein FAM227B isoform X1"
                     /calculated_mol_wt=62990
     Region          159..304
                     /region_name="FWWh"
                     /note="Protein of unknown function; pfam14922"
                     /db_xref="CDD:464378"
     Region          <423..489
                     /region_name="HOATZ-like"
                     /note="Cilia- and flagella-associated protein HOATZ-like;
                     pfam17664"
                     /db_xref="CDD:465445"
     CDS             1..533
                     /gene="FAM227B"
                     /gene_synonym="C15orf33"
                     /coded_by="XM_005254213.4:261..1862"
                     /db_xref="GeneID:196951"
                     /db_xref="HGNC:HGNC:26543"
ORIGIN      
        1 magqrtcqrr ssragpgkmq eppksieefl kfqnwdywpr eihfrdddkw sctlkkiked
       61 ssfvsiythl wenvprifea llimesklke yslilqnhts eifkwksmis etssyrkler
      121 ygeflkkyhk kkkimlsdem etekniegcs ftgfkanelt qlprhldaeq iylfilkahn
      181 fdervfkiwk thflseasia llhdsfwwwf lhkfrpdren qdclfdrise syvtlfmsip
      241 lsrkdaffqi ypdclaqaiy atfheafpes sylfndefke dlgnniflwc sglkpqkgfw
      301 ihwklkelst ttihgskkap aksvkeriad sqehistsid fniikilnnp raytlpiske
      361 esrlsrlatk shysstgpef nrvlfnfggq splilyylkm helagiskap kktkikltki
      421 fqeplpapty rdvikeakrq farnqkdfrm eklrineeik llkqqqerid keldrlqaka
      481 tkkphevkqd fekflhklrs eaeierecva slsssssssp sstdnynfee eey
//
LOCUS       XP_047288176             533 aa            linear   PRI 05-AUG-2025
DEFINITION  protein FAM227B isoform X1 [Homo sapiens].
ACCESSION   XP_047288176
VERSION     XP_047288176.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432220.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..533
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..533
                     /product="protein FAM227B isoform X1"
                     /calculated_mol_wt=62990
     Region          159..304
                     /region_name="FWWh"
                     /note="Protein of unknown function; pfam14922"
                     /db_xref="CDD:464378"
     Region          <423..489
                     /region_name="HOATZ-like"
                     /note="Cilia- and flagella-associated protein HOATZ-like;
                     pfam17664"
                     /db_xref="CDD:465445"
     CDS             1..533
                     /gene="FAM227B"
                     /gene_synonym="C15orf33"
                     /coded_by="XM_047432220.1:2439..4040"
                     /db_xref="GeneID:196951"
                     /db_xref="HGNC:HGNC:26543"
ORIGIN      
        1 magqrtcqrr ssragpgkmq eppksieefl kfqnwdywpr eihfrdddkw sctlkkiked
       61 ssfvsiythl wenvprifea llimesklke yslilqnhts eifkwksmis etssyrkler
      121 ygeflkkyhk kkkimlsdem etekniegcs ftgfkanelt qlprhldaeq iylfilkahn
      181 fdervfkiwk thflseasia llhdsfwwwf lhkfrpdren qdclfdrise syvtlfmsip
      241 lsrkdaffqi ypdclaqaiy atfheafpes sylfndefke dlgnniflwc sglkpqkgfw
      301 ihwklkelst ttihgskkap aksvkeriad sqehistsid fniikilnnp raytlpiske
      361 esrlsrlatk shysstgpef nrvlfnfggq splilyylkm helagiskap kktkikltki
      421 fqeplpapty rdvikeakrq farnqkdfrm eklrineeik llkqqqerid keldrlqaka
      481 tkkphevkqd fekflhklrs eaeierecva slsssssssp sstdnynfee eey
//
LOCUS       XP_006720486             533 aa            linear   PRI 05-AUG-2025
DEFINITION  protein FAM227B isoform X1 [Homo sapiens].
ACCESSION   XP_006720486
VERSION     XP_006720486.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720423.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..533
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..533
                     /product="protein FAM227B isoform X1"
                     /calculated_mol_wt=62990
     Region          159..304
                     /region_name="FWWh"
                     /note="Protein of unknown function; pfam14922"
                     /db_xref="CDD:464378"
     Region          <423..489
                     /region_name="HOATZ-like"
                     /note="Cilia- and flagella-associated protein HOATZ-like;
                     pfam17664"
                     /db_xref="CDD:465445"
     CDS             1..533
                     /gene="FAM227B"
                     /gene_synonym="C15orf33"
                     /coded_by="XM_006720423.4:249..1850"
                     /db_xref="GeneID:196951"
                     /db_xref="HGNC:HGNC:26543"
ORIGIN      
        1 magqrtcqrr ssragpgkmq eppksieefl kfqnwdywpr eihfrdddkw sctlkkiked
       61 ssfvsiythl wenvprifea llimesklke yslilqnhts eifkwksmis etssyrkler
      121 ygeflkkyhk kkkimlsdem etekniegcs ftgfkanelt qlprhldaeq iylfilkahn
      181 fdervfkiwk thflseasia llhdsfwwwf lhkfrpdren qdclfdrise syvtlfmsip
      241 lsrkdaffqi ypdclaqaiy atfheafpes sylfndefke dlgnniflwc sglkpqkgfw
      301 ihwklkelst ttihgskkap aksvkeriad sqehistsid fniikilnnp raytlpiske
      361 esrlsrlatk shysstgpef nrvlfnfggq splilyylkm helagiskap kktkikltki
      421 fqeplpapty rdvikeakrq farnqkdfrm eklrineeik llkqqqerid keldrlqaka
      481 tkkphevkqd fekflhklrs eaeierecva slsssssssp sstdnynfee eey
//
LOCUS       XP_005254272             521 aa            linear   PRI 05-AUG-2025
DEFINITION  protein FAM227B isoform X2 [Homo sapiens].
ACCESSION   XP_005254272
VERSION     XP_005254272.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254215.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..521
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..521
                     /product="protein FAM227B isoform X2"
                     /calculated_mol_wt=61571
     Region          147..292
                     /region_name="FWWh"
                     /note="Protein of unknown function; pfam14922"
                     /db_xref="CDD:464378"
     Region          <411..477
                     /region_name="HOATZ-like"
                     /note="Cilia- and flagella-associated protein HOATZ-like;
                     pfam17664"
                     /db_xref="CDD:465445"
     CDS             1..521
                     /gene="FAM227B"
                     /gene_synonym="C15orf33"
                     /coded_by="XM_005254215.4:261..1826"
                     /db_xref="GeneID:196951"
                     /db_xref="HGNC:HGNC:26543"
ORIGIN      
        1 magqrtcqrr ssragpgkmq eppksieefl kfqnwdywpr eihfrdddkw sctlkkiked
       61 ssfvsiythl wenvprifea llimesklke yslilqnhts eifkwksmis etssyrkler
      121 ygeflkkyhk kkkimgcsft gfkaneltql prhldaeqiy lfilkahnfd ervfkiwkth
      181 flseasiall hdsfwwwflh kfrpdrenqd clfdrisesy vtlfmsipls rkdaffqiyp
      241 dclaqaiyat fheafpessy lfndefkedl gnniflwcsg lkpqkgfwih wklkelsttt
      301 ihgskkapak svkeriadsq ehistsidfn iikilnnpra ytlpiskees rlsrlatksh
      361 ysstgpefnr vlfnfggqsp lilyylkmhe lagiskapkk tkikltkifq eplpaptyrd
      421 vikeakrqfa rnqkdfrmek lrineeikll kqqqeridke ldrlqakatk kphevkqdfe
      481 kflhklrsea eierecvasl ssssssspss tdnynfeeee y
//
LOCUS       XP_005254273             499 aa            linear   PRI 05-AUG-2025
DEFINITION  protein FAM227B isoform X3 [Homo sapiens].
ACCESSION   XP_005254273
VERSION     XP_005254273.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254216.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..499
                     /product="protein FAM227B isoform X3"
                     /calculated_mol_wt=58939
     Region          159..270
                     /region_name="FWWh"
                     /note="Protein of unknown function; pfam14922"
                     /db_xref="CDD:464378"
     Region          <389..455
                     /region_name="HOATZ-like"
                     /note="Cilia- and flagella-associated protein HOATZ-like;
                     pfam17664"
                     /db_xref="CDD:465445"
     CDS             1..499
                     /gene="FAM227B"
                     /gene_synonym="C15orf33"
                     /coded_by="XM_005254216.4:261..1760"
                     /db_xref="GeneID:196951"
                     /db_xref="HGNC:HGNC:26543"
ORIGIN      
        1 magqrtcqrr ssragpgkmq eppksieefl kfqnwdywpr eihfrdddkw sctlkkiked
       61 ssfvsiythl wenvprifea llimesklke yslilqnhts eifkwksmis etssyrkler
      121 ygeflkkyhk kkkimlsdem etekniegcs ftgfkanelt qlprhldaeq iylfilkahn
      181 fdervfkiwk thflseasia llhdsfwwwf lhkfriypdc laqaiyatfh eafpessylf
      241 ndefkedlgn niflwcsglk pqkgfwihwk lkelstttih gskkapaksv keriadsqeh
      301 istsidfnii kilnnprayt lpiskeesrl srlatkshys stgpefnrvl fnfggqspli
      361 lyylkmhela giskapkktk ikltkifqep lpaptyrdvi keakrqfarn qkdfrmeklr
      421 ineeikllkq qqeridkeld rlqakatkkp hevkqdfekf lhklrseaei erecvaslss
      481 ssssspsstd nynfeeeey
//
LOCUS       XP_047288177             487 aa            linear   PRI 05-AUG-2025
DEFINITION  protein FAM227B isoform X4 [Homo sapiens].
ACCESSION   XP_047288177
VERSION     XP_047288177.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432221.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..487
                     /product="protein FAM227B isoform X4"
                     /calculated_mol_wt=57519
     Region          147..258
                     /region_name="FWWh"
                     /note="Protein of unknown function; pfam14922"
                     /db_xref="CDD:464378"
     Region          <377..443
                     /region_name="HOATZ-like"
                     /note="Cilia- and flagella-associated protein HOATZ-like;
                     pfam17664"
                     /db_xref="CDD:465445"
     CDS             1..487
                     /gene="FAM227B"
                     /gene_synonym="C15orf33"
                     /coded_by="XM_047432221.1:192..1655"
                     /db_xref="GeneID:196951"
                     /db_xref="HGNC:HGNC:26543"
ORIGIN      
        1 magqrtcqrr ssragpgkmq eppksieefl kfqnwdywpr eihfrdddkw sctlkkiked
       61 ssfvsiythl wenvprifea llimesklke yslilqnhts eifkwksmis etssyrkler
      121 ygeflkkyhk kkkimgcsft gfkaneltql prhldaeqiy lfilkahnfd ervfkiwkth
      181 flseasiall hdsfwwwflh kfriypdcla qaiyatfhea fpessylfnd efkedlgnni
      241 flwcsglkpq kgfwihwklk elstttihgs kkapaksvke riadsqehis tsidfniiki
      301 lnnpraytlp iskeesrlsr latkshysst gpefnrvlfn fggqsplily ylkmhelagi
      361 skapkktkik ltkifqeplp aptyrdvike akrqfarnqk dfrmeklrin eeikllkqqq
      421 eridkeldrl qakatkkphe vkqdfekflh klrseaeier ecvaslssss ssspsstdny
      481 nfeeeey
//
LOCUS       XP_006720489             486 aa            linear   PRI 05-AUG-2025
DEFINITION  protein FAM227B isoform X5 [Homo sapiens].
ACCESSION   XP_006720489
VERSION     XP_006720489.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720426.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..486
                     /product="protein FAM227B isoform X5"
                     /calculated_mol_wt=57550
     Region          136..257
                     /region_name="FWWh"
                     /note="Protein of unknown function; pfam14922"
                     /db_xref="CDD:464378"
     Region          <376..442
                     /region_name="HOATZ-like"
                     /note="Cilia- and flagella-associated protein HOATZ-like;
                     pfam17664"
                     /db_xref="CDD:465445"
     CDS             1..486
                     /gene="FAM227B"
                     /gene_synonym="C15orf33"
                     /coded_by="XM_006720426.3:261..1721"
                     /db_xref="GeneID:196951"
                     /db_xref="HGNC:HGNC:26543"
ORIGIN      
        1 magqrtcqrr ssragpgkmq eppksieefl kfqnwdywpr eihfrdddkw sctlkkiked
       61 ssfvsiythl wenvprifea llimesklke yslilqnhts eifkwksmis etssyrkler
      121 ygeflkkyhk kkkimervfk iwkthflsea siallhdsfw wwflhkfrpd renqdclfdr
      181 isesyvtlfm siplsrkdaf fqiypdclaq aiyatfheaf pessylfnde fkedlgnnif
      241 lwcsglkpqk gfwihwklke lstttihgsk kapaksvker iadsqehist sidfniikil
      301 nnpraytlpi skeesrlsrl atkshysstg pefnrvlfnf ggqsplilyy lkmhelagis
      361 kapkktkikl tkifqeplpa ptyrdvikea krqfarnqkd frmeklrine eikllkqqqe
      421 ridkeldrlq akatkkphev kqdfekflhk lrseaeiere cvaslsssss sspsstdnyn
      481 feeeey
//
LOCUS       XP_047288178             486 aa            linear   PRI 05-AUG-2025
DEFINITION  protein FAM227B isoform X5 [Homo sapiens].
ACCESSION   XP_047288178
VERSION     XP_047288178.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432222.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..486
                     /product="protein FAM227B isoform X5"
                     /calculated_mol_wt=57550
     Region          136..257
                     /region_name="FWWh"
                     /note="Protein of unknown function; pfam14922"
                     /db_xref="CDD:464378"
     Region          <376..442
                     /region_name="HOATZ-like"
                     /note="Cilia- and flagella-associated protein HOATZ-like;
                     pfam17664"
                     /db_xref="CDD:465445"
     CDS             1..486
                     /gene="FAM227B"
                     /gene_synonym="C15orf33"
                     /coded_by="XM_047432222.1:192..1652"
                     /db_xref="GeneID:196951"
                     /db_xref="HGNC:HGNC:26543"
ORIGIN      
        1 magqrtcqrr ssragpgkmq eppksieefl kfqnwdywpr eihfrdddkw sctlkkiked
       61 ssfvsiythl wenvprifea llimesklke yslilqnhts eifkwksmis etssyrkler
      121 ygeflkkyhk kkkimervfk iwkthflsea siallhdsfw wwflhkfrpd renqdclfdr
      181 isesyvtlfm siplsrkdaf fqiypdclaq aiyatfheaf pessylfnde fkedlgnnif
      241 lwcsglkpqk gfwihwklke lstttihgsk kapaksvker iadsqehist sidfniikil
      301 nnpraytlpi skeesrlsrl atkshysstg pefnrvlfnf ggqsplilyy lkmhelagis
      361 kapkktkikl tkifqeplpa ptyrdvikea krqfarnqkd frmeklrine eikllkqqqe
      421 ridkeldrlq akatkkphev kqdfekflhk lrseaeiere cvaslsssss sspsstdnyn
      481 feeeey
//
LOCUS       XP_016877479             452 aa            linear   PRI 05-AUG-2025
DEFINITION  protein FAM227B isoform X6 [Homo sapiens].
ACCESSION   XP_016877479
VERSION     XP_016877479.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021990.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..452
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..452
                     /product="protein FAM227B isoform X6"
                     /calculated_mol_wt=53499
     Region          136..223
                     /region_name="FWWh"
                     /note="Protein of unknown function; pfam14922"
                     /db_xref="CDD:464378"
     Region          <342..408
                     /region_name="HOATZ-like"
                     /note="Cilia- and flagella-associated protein HOATZ-like;
                     pfam17664"
                     /db_xref="CDD:465445"
     CDS             1..452
                     /gene="FAM227B"
                     /gene_synonym="C15orf33"
                     /coded_by="XM_017021990.2:261..1619"
                     /db_xref="GeneID:196951"
                     /db_xref="HGNC:HGNC:26543"
ORIGIN      
        1 magqrtcqrr ssragpgkmq eppksieefl kfqnwdywpr eihfrdddkw sctlkkiked
       61 ssfvsiythl wenvprifea llimesklke yslilqnhts eifkwksmis etssyrkler
      121 ygeflkkyhk kkkimervfk iwkthflsea siallhdsfw wwflhkfriy pdclaqaiya
      181 tfheafpess ylfndefked lgnniflwcs glkpqkgfwi hwklkelstt tihgskkapa
      241 ksvkeriads qehistsidf niikilnnpr aytlpiskee srlsrlatks hysstgpefn
      301 rvlfnfggqs plilyylkmh elagiskapk ktkikltkif qeplpaptyr dvikeakrqf
      361 arnqkdfrme klrineeikl lkqqqeridk eldrlqakat kkphevkqdf ekflhklrse
      421 aeierecvas lsssssssps stdnynfeee ey
//
LOCUS       XP_047288179             450 aa            linear   PRI 05-AUG-2025
DEFINITION  protein FAM227B isoform X7 [Homo sapiens].
ACCESSION   XP_047288179
VERSION     XP_047288179.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432223.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..450
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..450
                     /product="protein FAM227B isoform X7"
                     /calculated_mol_wt=53004
     Region          76..221
                     /region_name="FWWh"
                     /note="Protein of unknown function; pfam14922"
                     /db_xref="CDD:464378"
     Region          <340..406
                     /region_name="HOATZ-like"
                     /note="Cilia- and flagella-associated protein HOATZ-like;
                     pfam17664"
                     /db_xref="CDD:465445"
     CDS             1..450
                     /gene="FAM227B"
                     /gene_synonym="C15orf33"
                     /coded_by="XM_047432223.1:301..1653"
                     /db_xref="GeneID:196951"
                     /db_xref="HGNC:HGNC:26543"
ORIGIN      
        1 mesklkeysl ilqnhtseif kwksmisets syrkleryge flkkyhkkkk imlsdemete
       61 kniegcsftg fkaneltqlp rhldaeqiyl filkahnfde rvfkiwkthf lseasiallh
      121 dsfwwwflhk frpdrenqdc lfdrisesyv tlfmsiplsr kdaffqiypd claqaiyatf
      181 heafpessyl fndefkedlg nniflwcsgl kpqkgfwihw klkelsttti hgskkapaks
      241 vkeriadsqe histsidfni ikilnnpray tlpiskeesr lsrlatkshy sstgpefnrv
      301 lfnfggqspl ilyylkmhel agiskapkkt kikltkifqe plpaptyrdv ikeakrqfar
      361 nqkdfrmekl rineeikllk qqqeridkel drlqakatkk phevkqdfek flhklrseae
      421 ierecvasls sssssspsst dnynfeeeey
//
LOCUS       XP_016877483             419 aa            linear   PRI 05-AUG-2025
DEFINITION  protein FAM227B isoform X8 [Homo sapiens].
ACCESSION   XP_016877483
VERSION     XP_016877483.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021994.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..419
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..419
                     /product="protein FAM227B isoform X8"
                     /calculated_mol_wt=49254
     Region          <135..190
                     /region_name="FWWh"
                     /note="Protein of unknown function; pfam14922"
                     /db_xref="CDD:464378"
     Region          <309..375
                     /region_name="HOATZ-like"
                     /note="Cilia- and flagella-associated protein HOATZ-like;
                     pfam17664"
                     /db_xref="CDD:465445"
     CDS             1..419
                     /gene="FAM227B"
                     /gene_synonym="C15orf33"
                     /coded_by="XM_017021994.2:261..1520"
                     /db_xref="GeneID:196951"
                     /db_xref="HGNC:HGNC:26543"
ORIGIN      
        1 magqrtcqrr ssragpgkmq eppksieefl kfqnwdywpr eihfrdddkw sctlkkiked
       61 ssfvsiythl wenvprifea llimesklke yslilqnhts eifkwksmis etssyrkler
      121 ygeflkkyhk kkkimiypdc laqaiyatfh eafpessylf ndefkedlgn niflwcsglk
      181 pqkgfwihwk lkelstttih gskkapaksv keriadsqeh istsidfnii kilnnprayt
      241 lpiskeesrl srlatkshys stgpefnrvl fnfggqspli lyylkmhela giskapkktk
      301 ikltkifqep lpaptyrdvi keakrqfarn qkdfrmeklr ineeikllkq qqeridkeld
      361 rlqakatkkp hevkqdfekf lhklrseaei erecvaslss ssssspsstd nynfeeeey
//
LOCUS       XP_047288180             419 aa            linear   PRI 05-AUG-2025
DEFINITION  protein FAM227B isoform X8 [Homo sapiens].
ACCESSION   XP_047288180
VERSION     XP_047288180.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432224.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..419
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..419
                     /product="protein FAM227B isoform X8"
                     /calculated_mol_wt=49254
     Region          <135..190
                     /region_name="FWWh"
                     /note="Protein of unknown function; pfam14922"
                     /db_xref="CDD:464378"
     Region          <309..375
                     /region_name="HOATZ-like"
                     /note="Cilia- and flagella-associated protein HOATZ-like;
                     pfam17664"
                     /db_xref="CDD:465445"
     CDS             1..419
                     /gene="FAM227B"
                     /gene_synonym="C15orf33"
                     /coded_by="XM_047432224.1:192..1451"
                     /db_xref="GeneID:196951"
                     /db_xref="HGNC:HGNC:26543"
ORIGIN      
        1 magqrtcqrr ssragpgkmq eppksieefl kfqnwdywpr eihfrdddkw sctlkkiked
       61 ssfvsiythl wenvprifea llimesklke yslilqnhts eifkwksmis etssyrkler
      121 ygeflkkyhk kkkimiypdc laqaiyatfh eafpessylf ndefkedlgn niflwcsglk
      181 pqkgfwihwk lkelstttih gskkapaksv keriadsqeh istsidfnii kilnnprayt
      241 lpiskeesrl srlatkshys stgpefnrvl fnfggqspli lyylkmhela giskapkktk
      301 ikltkifqep lpaptyrdvi keakrqfarn qkdfrmeklr ineeikllkq qqeridkeld
      361 rlqakatkkp hevkqdfekf lhklrseaei erecvaslss ssssspsstd nynfeeeey
//
LOCUS       XP_016877484             400 aa            linear   PRI 05-AUG-2025
DEFINITION  protein FAM227B isoform X9 [Homo sapiens].
ACCESSION   XP_016877484
VERSION     XP_016877484.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021995.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..400
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..400
                     /product="protein FAM227B isoform X9"
                     /calculated_mol_wt=47417
     Region          159..304
                     /region_name="FWWh"
                     /note="Protein of unknown function; pfam14922"
                     /db_xref="CDD:464378"
     CDS             1..400
                     /gene="FAM227B"
                     /gene_synonym="C15orf33"
                     /coded_by="XM_017021995.2:261..1463"
                     /db_xref="GeneID:196951"
                     /db_xref="HGNC:HGNC:26543"
ORIGIN      
        1 magqrtcqrr ssragpgkmq eppksieefl kfqnwdywpr eihfrdddkw sctlkkiked
       61 ssfvsiythl wenvprifea llimesklke yslilqnhts eifkwksmis etssyrkler
      121 ygeflkkyhk kkkimlsdem etekniegcs ftgfkanelt qlprhldaeq iylfilkahn
      181 fdervfkiwk thflseasia llhdsfwwwf lhkfrpdren qdclfdrise syvtlfmsip
      241 lsrkdaffqi ypdclaqaiy atfheafpes sylfndefke dlgnniflwc sglkpqkgfw
      301 ihwklkelst ttihgskkap aksvkeriad sqehistsid fniikilnnp raytlpiske
      361 esrlsrlatk shysstgpef nrvlfnfgds kqrlprnlmk
//
LOCUS       XP_016877485             399 aa            linear   PRI 05-AUG-2025
DEFINITION  protein FAM227B isoform X10 [Homo sapiens].
ACCESSION   XP_016877485
VERSION     XP_016877485.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017021996.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..399
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..399
                     /product="protein FAM227B isoform X10"
                     /calculated_mol_wt=46707
     Region          25..170
                     /region_name="FWWh"
                     /note="Protein of unknown function; pfam14922"
                     /db_xref="CDD:464378"
     Region          <289..355
                     /region_name="HOATZ-like"
                     /note="Cilia- and flagella-associated protein HOATZ-like;
                     pfam17664"
                     /db_xref="CDD:465445"
     CDS             1..399
                     /gene="FAM227B"
                     /gene_synonym="C15orf33"
                     /coded_by="XM_017021996.2:222..1421"
                     /db_xref="GeneID:196951"
                     /db_xref="HGNC:HGNC:26543"
ORIGIN      
        1 mlsdemetek niegcsftgf kaneltqlpr hldaeqiylf ilkahnfder vfkiwkthfl
       61 seasiallhd sfwwwflhkf rpdrenqdcl fdrisesyvt lfmsiplsrk daffqiypdc
      121 laqaiyatfh eafpessylf ndefkedlgn niflwcsglk pqkgfwihwk lkelstttih
      181 gskkapaksv keriadsqeh istsidfnii kilnnprayt lpiskeesrl srlatkshys
      241 stgpefnrvl fnfggqspli lyylkmhela giskapkktk ikltkifqep lpaptyrdvi
      301 keakrqfarn qkdfrmeklr ineeikllkq qqeridkeld rlqakatkkp hevkqdfekf
      361 lhklrseaei erecvaslss ssssspsstd nynfeeeey
//
LOCUS       XP_011519622             399 aa            linear   PRI 05-AUG-2025
DEFINITION  protein FAM227B isoform X10 [Homo sapiens].
ACCESSION   XP_011519622
VERSION     XP_011519622.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521320.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..399
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..399
                     /product="protein FAM227B isoform X10"
                     /calculated_mol_wt=46707
     Region          25..170
                     /region_name="FWWh"
                     /note="Protein of unknown function; pfam14922"
                     /db_xref="CDD:464378"
     Region          <289..355
                     /region_name="HOATZ-like"
                     /note="Cilia- and flagella-associated protein HOATZ-like;
                     pfam17664"
                     /db_xref="CDD:465445"
     CDS             1..399
                     /gene="FAM227B"
                     /gene_synonym="C15orf33"
                     /coded_by="XM_011521320.2:149..1348"
                     /db_xref="GeneID:196951"
                     /db_xref="HGNC:HGNC:26543"
ORIGIN      
        1 mlsdemetek niegcsftgf kaneltqlpr hldaeqiylf ilkahnfder vfkiwkthfl
       61 seasiallhd sfwwwflhkf rpdrenqdcl fdrisesyvt lfmsiplsrk daffqiypdc
      121 laqaiyatfh eafpessylf ndefkedlgn niflwcsglk pqkgfwihwk lkelstttih
      181 gskkapaksv keriadsqeh istsidfnii kilnnprayt lpiskeesrl srlatkshys
      241 stgpefnrvl fnfggqspli lyylkmhela giskapkktk ikltkifqep lpaptyrdvi
      301 keakrqfarn qkdfrmeklr ineeikllkq qqeridkeld rlqakatkkp hevkqdfekf
      361 lhklrseaei erecvaslss ssssspsstd nynfeeeey
//
LOCUS       XP_011519623             392 aa            linear   PRI 05-AUG-2025
DEFINITION  protein FAM227B isoform X11 [Homo sapiens].
ACCESSION   XP_011519623
VERSION     XP_011519623.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521321.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..392
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..392
                     /product="protein FAM227B isoform X11"
                     /calculated_mol_wt=46392
     Region          159..304
                     /region_name="FWWh"
                     /note="Protein of unknown function; pfam14922"
                     /db_xref="CDD:464378"
     CDS             1..392
                     /gene="FAM227B"
                     /gene_synonym="C15orf33"
                     /coded_by="XM_011521321.3:261..1439"
                     /db_xref="GeneID:196951"
                     /db_xref="HGNC:HGNC:26543"
ORIGIN      
        1 magqrtcqrr ssragpgkmq eppksieefl kfqnwdywpr eihfrdddkw sctlkkiked
       61 ssfvsiythl wenvprifea llimesklke yslilqnhts eifkwksmis etssyrkler
      121 ygeflkkyhk kkkimlsdem etekniegcs ftgfkanelt qlprhldaeq iylfilkahn
      181 fdervfkiwk thflseasia llhdsfwwwf lhkfrpdren qdclfdrise syvtlfmsip
      241 lsrkdaffqi ypdclaqaiy atfheafpes sylfndefke dlgnniflwc sglkpqkgfw
      301 ihwklkelst ttihgskkap aksvkeriad sqehistsid fniikilnnp raytlpiske
      361 esrlsrlatk shysstgpef nrvlfnfgei tv
//
LOCUS       XP_011519624             387 aa            linear   PRI 05-AUG-2025
DEFINITION  protein FAM227B isoform X12 [Homo sapiens].
ACCESSION   XP_011519624
VERSION     XP_011519624.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521322.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..387
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..387
                     /product="protein FAM227B isoform X12"
                     /calculated_mol_wt=45288
     Region          13..158
                     /region_name="FWWh"
                     /note="Protein of unknown function; pfam14922"
                     /db_xref="CDD:464378"
     Region          <277..343
                     /region_name="HOATZ-like"
                     /note="Cilia- and flagella-associated protein HOATZ-like;
                     pfam17664"
                     /db_xref="CDD:465445"
     CDS             1..387
                     /gene="FAM227B"
                     /gene_synonym="C15orf33"
                     /coded_by="XM_011521322.2:149..1312"
                     /db_xref="GeneID:196951"
                     /db_xref="HGNC:HGNC:26543"
ORIGIN      
        1 mgcsftgfka neltqlprhl daeqiylfil kahnfdervf kiwkthflse asiallhdsf
       61 wwwflhkfrp drenqdclfd risesyvtlf msiplsrkda ffqiypdcla qaiyatfhea
      121 fpessylfnd efkedlgnni flwcsglkpq kgfwihwklk elstttihgs kkapaksvke
      181 riadsqehis tsidfniiki lnnpraytlp iskeesrlsr latkshysst gpefnrvlfn
      241 fggqsplily ylkmhelagi skapkktkik ltkifqeplp aptyrdvike akrqfarnqk
      301 dfrmeklrin eeikllkqqq eridkeldrl qakatkkphe vkqdfekflh klrseaeier
      361 ecvaslssss ssspsstdny nfeeeey
//
LOCUS       XP_047288181             380 aa            linear   PRI 05-AUG-2025
DEFINITION  protein FAM227B isoform X13 [Homo sapiens].
ACCESSION   XP_047288181
VERSION     XP_047288181.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432225.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..380
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..380
                     /product="protein FAM227B isoform X13"
                     /calculated_mol_wt=44988
     Region          159..304
                     /region_name="FWWh"
                     /note="Protein of unknown function; pfam14922"
                     /db_xref="CDD:464378"
     CDS             1..380
                     /gene="FAM227B"
                     /gene_synonym="C15orf33"
                     /coded_by="XM_047432225.1:261..1403"
                     /db_xref="GeneID:196951"
                     /db_xref="HGNC:HGNC:26543"
ORIGIN      
        1 magqrtcqrr ssragpgkmq eppksieefl kfqnwdywpr eihfrdddkw sctlkkiked
       61 ssfvsiythl wenvprifea llimesklke yslilqnhts eifkwksmis etssyrkler
      121 ygeflkkyhk kkkimlsdem etekniegcs ftgfkanelt qlprhldaeq iylfilkahn
      181 fdervfkiwk thflseasia llhdsfwwwf lhkfrpdren qdclfdrise syvtlfmsip
      241 lsrkdaffqi ypdclaqaiy atfheafpes sylfndefke dlgnniflwc sglkpqkgfw
      301 ihwklkelst ttihgskkap aksvkeriad sqehistsid fniikilnnp raytlpiske
      361 esrlsrlatk tpskgyqets
//
LOCUS       XP_047288182             345 aa            linear   PRI 05-AUG-2025
DEFINITION  protein FAM227B isoform X14 [Homo sapiens].
ACCESSION   XP_047288182
VERSION     XP_047288182.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432226.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..345
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..345
                     /product="protein FAM227B isoform X14"
                     /calculated_mol_wt=41064
     Region          159..304
                     /region_name="FWWh"
                     /note="Protein of unknown function; pfam14922"
                     /db_xref="CDD:464378"
     CDS             1..345
                     /gene="FAM227B"
                     /gene_synonym="C15orf33"
                     /coded_by="XM_047432226.1:261..1298"
                     /db_xref="GeneID:196951"
                     /db_xref="HGNC:HGNC:26543"
ORIGIN      
        1 magqrtcqrr ssragpgkmq eppksieefl kfqnwdywpr eihfrdddkw sctlkkiked
       61 ssfvsiythl wenvprifea llimesklke yslilqnhts eifkwksmis etssyrkler
      121 ygeflkkyhk kkkimlsdem etekniegcs ftgfkanelt qlprhldaeq iylfilkahn
      181 fdervfkiwk thflseasia llhdsfwwwf lhkfrpdren qdclfdrise syvtlfmsip
      241 lsrkdaffqi ypdclaqaiy atfheafpes sylfndefke dlgnniflwc sglkpqkgfw
      301 ihwklkelst ttihgskkap aksvkeriad sqehistktv rektp
//
LOCUS       XP_047288183             345 aa            linear   PRI 05-AUG-2025
DEFINITION  protein FAM227B isoform X14 [Homo sapiens].
ACCESSION   XP_047288183
VERSION     XP_047288183.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432227.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..345
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..345
                     /product="protein FAM227B isoform X14"
                     /calculated_mol_wt=41064
     Region          159..304
                     /region_name="FWWh"
                     /note="Protein of unknown function; pfam14922"
                     /db_xref="CDD:464378"
     CDS             1..345
                     /gene="FAM227B"
                     /gene_synonym="C15orf33"
                     /coded_by="XM_047432227.1:261..1298"
                     /db_xref="GeneID:196951"
                     /db_xref="HGNC:HGNC:26543"
ORIGIN      
        1 magqrtcqrr ssragpgkmq eppksieefl kfqnwdywpr eihfrdddkw sctlkkiked
       61 ssfvsiythl wenvprifea llimesklke yslilqnhts eifkwksmis etssyrkler
      121 ygeflkkyhk kkkimlsdem etekniegcs ftgfkanelt qlprhldaeq iylfilkahn
      181 fdervfkiwk thflseasia llhdsfwwwf lhkfrpdren qdclfdrise syvtlfmsip
      241 lsrkdaffqi ypdclaqaiy atfheafpes sylfndefke dlgnniflwc sglkpqkgfw
      301 ihwklkelst ttihgskkap aksvkeriad sqehistktv rektp
//
LOCUS       XP_011519627             338 aa            linear   PRI 05-AUG-2025
DEFINITION  protein FAM227B isoform X15 [Homo sapiens].
ACCESSION   XP_011519627
VERSION     XP_011519627.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521325.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..338
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..338
                     /product="protein FAM227B isoform X15"
                     /calculated_mol_wt=40237
     Region          159..304
                     /region_name="FWWh"
                     /note="Protein of unknown function; pfam14922"
                     /db_xref="CDD:464378"
     CDS             1..338
                     /gene="FAM227B"
                     /gene_synonym="C15orf33"
                     /coded_by="XM_011521325.4:261..1277"
                     /db_xref="GeneID:196951"
                     /db_xref="HGNC:HGNC:26543"
ORIGIN      
        1 magqrtcqrr ssragpgkmq eppksieefl kfqnwdywpr eihfrdddkw sctlkkiked
       61 ssfvsiythl wenvprifea llimesklke yslilqnhts eifkwksmis etssyrkler
      121 ygeflkkyhk kkkimlsdem etekniegcs ftgfkanelt qlprhldaeq iylfilkahn
      181 fdervfkiwk thflseasia llhdsfwwwf lhkfrpdren qdclfdrise syvtlfmsip
      241 lsrkdaffqi ypdclaqaiy atfheafpes sylfndefke dlgnniflwc sglkpqkgfw
      301 ihwklkelst ttihgskkap aksvkeriad sqehisti
//
LOCUS       XP_011519626             338 aa            linear   PRI 05-AUG-2025
DEFINITION  protein FAM227B isoform X16 [Homo sapiens].
ACCESSION   XP_011519626
VERSION     XP_011519626.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521324.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..338
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..338
                     /product="protein FAM227B isoform X16"
                     /calculated_mol_wt=40211
     Region          159..304
                     /region_name="FWWh"
                     /note="Protein of unknown function; pfam14922"
                     /db_xref="CDD:464378"
     CDS             1..338
                     /gene="FAM227B"
                     /gene_synonym="C15orf33"
                     /coded_by="XM_011521324.2:261..1277"
                     /db_xref="GeneID:196951"
                     /db_xref="HGNC:HGNC:26543"
ORIGIN      
        1 magqrtcqrr ssragpgkmq eppksieefl kfqnwdywpr eihfrdddkw sctlkkiked
       61 ssfvsiythl wenvprifea llimesklke yslilqnhts eifkwksmis etssyrkler
      121 ygeflkkyhk kkkimlsdem etekniegcs ftgfkanelt qlprhldaeq iylfilkahn
      181 fdervfkiwk thflseasia llhdsfwwwf lhkfrpdren qdclfdrise syvtlfmsip
      241 lsrkdaffqi ypdclaqaiy atfheafpes sylfndefke dlgnniflwc sglkpqkgfw
      301 ihwklkelst ttihgskkap aksvkeriad sqehists
//
LOCUS       XP_024305631             329 aa            linear   PRI 05-AUG-2025
DEFINITION  protein FAM227B isoform X17 [Homo sapiens].
ACCESSION   XP_024305631
VERSION     XP_024305631.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449863.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..329
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..329
                     /product="protein FAM227B isoform X17"
                     /calculated_mol_wt=39319
     Region          159..270
                     /region_name="FWWh"
                     /note="Protein of unknown function; pfam14922"
                     /db_xref="CDD:464378"
     CDS             1..329
                     /gene="FAM227B"
                     /gene_synonym="C15orf33"
                     /coded_by="XM_024449863.2:192..1181"
                     /db_xref="GeneID:196951"
                     /db_xref="HGNC:HGNC:26543"
ORIGIN      
        1 magqrtcqrr ssragpgkmq eppksieefl kfqnwdywpr eihfrdddkw sctlkkiked
       61 ssfvsiythl wenvprifea llimesklke yslilqnhts eifkwksmis etssyrkler
      121 ygeflkkyhk kkkimlsdem etekniegcs ftgfkanelt qlprhldaeq iylfilkahn
      181 fdervfkiwk thflseasia llhdsfwwwf lhkfriypdc laqaiyatfh eafpessylf
      241 ndefkedlgn niflwcsglk pqkgfwihwk lkelstttih gskkapaksv keriadsqeh
      301 istrmdhavs lkeesrmfpq riyifhlfl
//
LOCUS       XP_047288184             326 aa            linear   PRI 05-AUG-2025
DEFINITION  protein FAM227B isoform X18 [Homo sapiens].
ACCESSION   XP_047288184
VERSION     XP_047288184.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432228.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..326
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..326
                     /product="protein FAM227B isoform X18"
                     /calculated_mol_wt=38792
     Region          147..292
                     /region_name="FWWh"
                     /note="Protein of unknown function; pfam14922"
                     /db_xref="CDD:464378"
     CDS             1..326
                     /gene="FAM227B"
                     /gene_synonym="C15orf33"
                     /coded_by="XM_047432228.1:261..1241"
                     /db_xref="GeneID:196951"
                     /db_xref="HGNC:HGNC:26543"
ORIGIN      
        1 magqrtcqrr ssragpgkmq eppksieefl kfqnwdywpr eihfrdddkw sctlkkiked
       61 ssfvsiythl wenvprifea llimesklke yslilqnhts eifkwksmis etssyrkler
      121 ygeflkkyhk kkkimgcsft gfkaneltql prhldaeqiy lfilkahnfd ervfkiwkth
      181 flseasiall hdsfwwwflh kfrpdrenqd clfdrisesy vtlfmsipls rkdaffqiyp
      241 dclaqaiyat fheafpessy lfndefkedl gnniflwcsg lkpqkgfwih wklkelsttt
      301 ihgskkapak svkeriadsq ehists
//
LOCUS       XP_024305633             291 aa            linear   PRI 05-AUG-2025
DEFINITION  protein FAM227B isoform X19 [Homo sapiens].
ACCESSION   XP_024305633
VERSION     XP_024305633.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449865.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..291
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..291
                     /product="protein FAM227B isoform X19"
                     /calculated_mol_wt=34771
     Region          136..257
                     /region_name="FWWh"
                     /note="Protein of unknown function; pfam14922"
                     /db_xref="CDD:464378"
     CDS             1..291
                     /gene="FAM227B"
                     /gene_synonym="C15orf33"
                     /coded_by="XM_024449865.2:192..1067"
                     /db_xref="GeneID:196951"
                     /db_xref="HGNC:HGNC:26543"
ORIGIN      
        1 magqrtcqrr ssragpgkmq eppksieefl kfqnwdywpr eihfrdddkw sctlkkiked
       61 ssfvsiythl wenvprifea llimesklke yslilqnhts eifkwksmis etssyrkler
      121 ygeflkkyhk kkkimervfk iwkthflsea siallhdsfw wwflhkfrpd renqdclfdr
      181 isesyvtlfm siplsrkdaf fqiypdclaq aiyatfheaf pessylfnde fkedlgnnif
      241 lwcsglkpqk gfwihwklke lstttihgsk kapaksvker iadsqehist s
//
LOCUS       XP_011519638             603 aa            linear   PRI 05-AUG-2025
DEFINITION  protein PAT1 homolog 2 isoform X1 [Homo sapiens].
ACCESSION   XP_011519638
VERSION     XP_011519638.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521336.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Jun 6, 2016 this sequence version replaced XP_011519638.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..603
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..603
                     /product="protein PAT1 homolog 2 isoform X1"
                     /calculated_mol_wt=67668
     Region          <301..>451
                     /region_name="PAT1"
                     /note="Topoisomerase II-associated protein PAT1;
                     pfam09770"
                     /db_xref="CDD:401645"
     CDS             1..603
                     /gene="PATL2"
                     /gene_synonym="hPat1a; OOMD4; OZEMA4; Pat1a"
                     /coded_by="XM_011521336.3:806..2617"
                     /db_xref="GeneID:197135"
                     /db_xref="HGNC:HGNC:33630"
                     /db_xref="MIM:614661"
ORIGIN      
        1 mnnlnrkdsn sqvvylpeag navsledtak kevhqpakmn clegpgktcg plaseeelvs
       61 acqlekeeen egeeeeeeed eedldpdldp dleeeendlg dpavlgavhn tqrallsspg
      121 vkapgmlgms laslhflwqt ldylspipfw ptfpstsspa qhfgprlpsp dptlfcsllt
      181 swpprfshlt qlhprhqril qqqqhsqtps ppakkpwsqq pdpyanlmtr kekdwvikvq
      241 mvqlqsakpr lddyyyqeyy qklekkqade ellgrrnrve slklvtpyip kaeayesvvr
      301 iegslgqvav stcfsprrai davphgtqeq dieaassqrl rvlyriekmf lqlleieegw
      361 kyrppppcfs eqqsnqvekl fqtlktqeqn nleeaadgfl qvlsvrkgka lvarllpflp
      421 qdqavtilla ithhlpllvr rdvadqalqm lfkplgkcis hltlhellqg lqgltllppg
      481 sserpvtvvl qnqdrhggsd clgdspnays lsgrtpsfpq qptspvlspr gqtigsaagg
      541 qdgvcldlli clfwntcmwe vessdtsyid yvyrdpeslk tflmplyige pfpifisflq
      601 ksk
//
LOCUS       XP_011519639             600 aa            linear   PRI 05-AUG-2025
DEFINITION  protein PAT1 homolog 2 isoform X2 [Homo sapiens].
ACCESSION   XP_011519639
VERSION     XP_011519639.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521337.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Jun 6, 2016 this sequence version replaced XP_011519639.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..600
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..600
                     /product="protein PAT1 homolog 2 isoform X2"
                     /calculated_mol_wt=67382
     Region          <298..>448
                     /region_name="PAT1"
                     /note="Topoisomerase II-associated protein PAT1;
                     pfam09770"
                     /db_xref="CDD:401645"
     CDS             1..600
                     /gene="PATL2"
                     /gene_synonym="hPat1a; OOMD4; OZEMA4; Pat1a"
                     /coded_by="XM_011521337.3:960..2762"
                     /db_xref="GeneID:197135"
                     /db_xref="HGNC:HGNC:33630"
                     /db_xref="MIM:614661"
ORIGIN      
        1 mnnlnrkdsn sqvvylpeag navsledtak kevhqpakmn clegpgktcg plaseeelvs
       61 acqlekeeen egeeeeeeed eedldpdldp dleeeendlg dpavlgavhn tqererdpgp
      121 adfeseggps chcpgcwntw sccflpppqk hstsspaqhf gprlpspdpt lfcslltswp
      181 prfshltqlh prhqrilqqq qhsqtpsppa kkpwsqqpdp yanlmtrkek dwvikvqmvq
      241 lqsakprldd yyyqeyyqkl ekkqadeell grrnrveslk lvtpyipkae ayesvvrieg
      301 slgqvavstc fsprraidav phgtqeqdie aassqrlrvl yriekmflql leieegwkyr
      361 ppppcfseqq snqveklfqt lktqeqnnle eaadgflqvl svrkgkalva rllpflpqdq
      421 avtillaith hlpllvrrdv adqalqmlfk plgkcishlt lhellqglqg ltllppgsse
      481 rpvtvvlqnq drhggsdclg dspnayslsg rtpsfpqqpt spvlsprgqt igsaaggqdg
      541 vcldlliclf wntcmweves sdtsyidyvy rdpeslktfl mplyigepfp ifisflqksk
//
LOCUS       XP_011519640             565 aa            linear   PRI 05-AUG-2025
DEFINITION  protein PAT1 homolog 2 isoform X3 [Homo sapiens].
ACCESSION   XP_011519640
VERSION     XP_011519640.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521338.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..565
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..565
                     /product="protein PAT1 homolog 2 isoform X3"
                     /calculated_mol_wt=63489
     Region          <263..>413
                     /region_name="PAT1"
                     /note="Topoisomerase II-associated protein PAT1;
                     pfam09770"
                     /db_xref="CDD:401645"
     CDS             1..565
                     /gene="PATL2"
                     /gene_synonym="hPat1a; OOMD4; OZEMA4; Pat1a"
                     /coded_by="XM_011521338.4:558..2255"
                     /db_xref="GeneID:197135"
                     /db_xref="HGNC:HGNC:33630"
                     /db_xref="MIM:614661"
ORIGIN      
        1 mnclegpgkt cgplaseeel vsacqlekee enegeeeeee edeedldpdl dpdleeeend
       61 lgdpavlgav hntqrallss pgvkapgmlg mslaslhflw qtldylspip fwptfpstss
      121 paqhfgprlp spdptlfcsl ltswpprfsh ltqlhprhqr ilqqqqhsqt psppakkpws
      181 qqpdpyanlm trkekdwvik vqmvqlqsak prlddyyyqe yyqklekkqa deellgrrnr
      241 veslklvtpy ipkaeayesv vriegslgqv avstcfsprr aidavphgtq eqdieaassq
      301 rlrvlyriek mflqlleiee gwkyrppppc fseqqsnqve klfqtlktqe qnnleeaadg
      361 flqvlsvrkg kalvarllpf lpqdqavtil laithhlpll vrrdvadqal qmlfkplgkc
      421 ishltlhell qglqgltllp pgsserpvtv vlqnqdrhgg sdclgdspna yslsgrtpsf
      481 pqqptspvls prgqtigsaa ggqdgvcldl liclfwntcm wevessdtsy idyvyrdpes
      541 lktflmplyi gepfpifisf lqksk
//
LOCUS       XP_047288186             565 aa            linear   PRI 05-AUG-2025
DEFINITION  protein PAT1 homolog 2 isoform X3 [Homo sapiens].
ACCESSION   XP_047288186
VERSION     XP_047288186.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432230.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..565
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..565
                     /product="protein PAT1 homolog 2 isoform X3"
                     /calculated_mol_wt=63489
     Region          <263..>413
                     /region_name="PAT1"
                     /note="Topoisomerase II-associated protein PAT1;
                     pfam09770"
                     /db_xref="CDD:401645"
     CDS             1..565
                     /gene="PATL2"
                     /gene_synonym="hPat1a; OOMD4; OZEMA4; Pat1a"
                     /coded_by="XM_047432230.1:648..2345"
                     /db_xref="GeneID:197135"
                     /db_xref="HGNC:HGNC:33630"
                     /db_xref="MIM:614661"
ORIGIN      
        1 mnclegpgkt cgplaseeel vsacqlekee enegeeeeee edeedldpdl dpdleeeend
       61 lgdpavlgav hntqrallss pgvkapgmlg mslaslhflw qtldylspip fwptfpstss
      121 paqhfgprlp spdptlfcsl ltswpprfsh ltqlhprhqr ilqqqqhsqt psppakkpws
      181 qqpdpyanlm trkekdwvik vqmvqlqsak prlddyyyqe yyqklekkqa deellgrrnr
      241 veslklvtpy ipkaeayesv vriegslgqv avstcfsprr aidavphgtq eqdieaassq
      301 rlrvlyriek mflqlleiee gwkyrppppc fseqqsnqve klfqtlktqe qnnleeaadg
      361 flqvlsvrkg kalvarllpf lpqdqavtil laithhlpll vrrdvadqal qmlfkplgkc
      421 ishltlhell qglqgltllp pgsserpvtv vlqnqdrhgg sdclgdspna yslsgrtpsf
      481 pqqptspvls prgqtigsaa ggqdgvcldl liclfwntcm wevessdtsy idyvyrdpes
      541 lktflmplyi gepfpifisf lqksk
//
LOCUS       XP_011519641             565 aa            linear   PRI 05-AUG-2025
DEFINITION  protein PAT1 homolog 2 isoform X3 [Homo sapiens].
ACCESSION   XP_011519641
VERSION     XP_011519641.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521339.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..565
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..565
                     /product="protein PAT1 homolog 2 isoform X3"
                     /calculated_mol_wt=63489
     Region          <263..>413
                     /region_name="PAT1"
                     /note="Topoisomerase II-associated protein PAT1;
                     pfam09770"
                     /db_xref="CDD:401645"
     CDS             1..565
                     /gene="PATL2"
                     /gene_synonym="hPat1a; OOMD4; OZEMA4; Pat1a"
                     /coded_by="XM_011521339.4:439..2136"
                     /db_xref="GeneID:197135"
                     /db_xref="HGNC:HGNC:33630"
                     /db_xref="MIM:614661"
ORIGIN      
        1 mnclegpgkt cgplaseeel vsacqlekee enegeeeeee edeedldpdl dpdleeeend
       61 lgdpavlgav hntqrallss pgvkapgmlg mslaslhflw qtldylspip fwptfpstss
      121 paqhfgprlp spdptlfcsl ltswpprfsh ltqlhprhqr ilqqqqhsqt psppakkpws
      181 qqpdpyanlm trkekdwvik vqmvqlqsak prlddyyyqe yyqklekkqa deellgrrnr
      241 veslklvtpy ipkaeayesv vriegslgqv avstcfsprr aidavphgtq eqdieaassq
      301 rlrvlyriek mflqlleiee gwkyrppppc fseqqsnqve klfqtlktqe qnnleeaadg
      361 flqvlsvrkg kalvarllpf lpqdqavtil laithhlpll vrrdvadqal qmlfkplgkc
      421 ishltlhell qglqgltllp pgsserpvtv vlqnqdrhgg sdclgdspna yslsgrtpsf
      481 pqqptspvls prgqtigsaa ggqdgvcldl liclfwntcm wevessdtsy idyvyrdpes
      541 lktflmplyi gepfpifisf lqksk
//
LOCUS       XP_011519643             565 aa            linear   PRI 05-AUG-2025
DEFINITION  protein PAT1 homolog 2 isoform X3 [Homo sapiens].
ACCESSION   XP_011519643
VERSION     XP_011519643.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521341.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..565
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..565
                     /product="protein PAT1 homolog 2 isoform X3"
                     /calculated_mol_wt=63489
     Region          <263..>413
                     /region_name="PAT1"
                     /note="Topoisomerase II-associated protein PAT1;
                     pfam09770"
                     /db_xref="CDD:401645"
     CDS             1..565
                     /gene="PATL2"
                     /gene_synonym="hPat1a; OOMD4; OZEMA4; Pat1a"
                     /coded_by="XM_011521341.2:224..1921"
                     /db_xref="GeneID:197135"
                     /db_xref="HGNC:HGNC:33630"
                     /db_xref="MIM:614661"
ORIGIN      
        1 mnclegpgkt cgplaseeel vsacqlekee enegeeeeee edeedldpdl dpdleeeend
       61 lgdpavlgav hntqrallss pgvkapgmlg mslaslhflw qtldylspip fwptfpstss
      121 paqhfgprlp spdptlfcsl ltswpprfsh ltqlhprhqr ilqqqqhsqt psppakkpws
      181 qqpdpyanlm trkekdwvik vqmvqlqsak prlddyyyqe yyqklekkqa deellgrrnr
      241 veslklvtpy ipkaeayesv vriegslgqv avstcfsprr aidavphgtq eqdieaassq
      301 rlrvlyriek mflqlleiee gwkyrppppc fseqqsnqve klfqtlktqe qnnleeaadg
      361 flqvlsvrkg kalvarllpf lpqdqavtil laithhlpll vrrdvadqal qmlfkplgkc
      421 ishltlhell qglqgltllp pgsserpvtv vlqnqdrhgg sdclgdspna yslsgrtpsf
      481 pqqptspvls prgqtigsaa ggqdgvcldl liclfwntcm wevessdtsy idyvyrdpes
      541 lktflmplyi gepfpifisf lqksk
//
LOCUS       XP_047288187             550 aa            linear   PRI 05-AUG-2025
DEFINITION  protein PAT1 homolog 2 isoform X4 [Homo sapiens].
ACCESSION   XP_047288187
VERSION     XP_047288187.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432231.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..550
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..550
                     /product="protein PAT1 homolog 2 isoform X4"
                     /calculated_mol_wt=61972
     Region          <270..>420
                     /region_name="PAT1"
                     /note="Topoisomerase II-associated protein PAT1;
                     pfam09770"
                     /db_xref="CDD:401645"
     CDS             1..550
                     /gene="PATL2"
                     /gene_synonym="hPat1a; OOMD4; OZEMA4; Pat1a"
                     /coded_by="XM_047432231.1:958..2610"
                     /db_xref="GeneID:197135"
                     /db_xref="HGNC:HGNC:33630"
                     /db_xref="MIM:614661"
ORIGIN      
        1 mnnlnrkdsn sqvvylpeag navsledtak kevhqpakmn clegpgktcg plaseeelvs
       61 acqlekeeen egeeeeeeed eedldpdldp dleeeendlg dpavlgavhn tqrallsspg
      121 vkapgmlgms laslhflwqt ldylspipfw ptfpstsspa qhfgprlpsp dptlfcsllt
      181 swpprfshlt qlhprhqril qqqqhsqtpr ephfllttll rkcqwweyyq klekkqadee
      241 llgrrnrves lklvtpyipk aeayesvvri egslgqvavs tcfsprraid avphgtqeqd
      301 ieaassqrlr vlyriekmfl qlleieegwk yrppppcfse qqsnqveklf qtlktqeqnn
      361 leeaadgflq vlsvrkgkal varllpflpq dqavtillai thhlpllvrr dvadqalqml
      421 fkplgkcish ltlhellqgl qgltllppgs serpvtvvlq nqfgisllya llshgeqlvs
      481 lhssleepns dhtawtdmvv liaweiaqmp taslaeplaf psnllplfch hvdkqlvqql
      541 earmefawiy
//
LOCUS       XP_011519644             491 aa            linear   PRI 05-AUG-2025
DEFINITION  protein PAT1 homolog 2 isoform X5 [Homo sapiens].
ACCESSION   XP_011519644
VERSION     XP_011519644.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521342.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..491
                     /product="protein PAT1 homolog 2 isoform X5"
                     /calculated_mol_wt=55462
     Region          <189..>339
                     /region_name="PAT1"
                     /note="Topoisomerase II-associated protein PAT1;
                     pfam09770"
                     /db_xref="CDD:401645"
     CDS             1..491
                     /gene="PATL2"
                     /gene_synonym="hPat1a; OOMD4; OZEMA4; Pat1a"
                     /coded_by="XM_011521342.3:277..1752"
                     /db_xref="GeneID:197135"
                     /db_xref="HGNC:HGNC:33630"
                     /db_xref="MIM:614661"
ORIGIN      
        1 milgiqlylv lsttprelcl aplesrplvc wechlppcif cgstsspaqh fgprlpspdp
       61 tlfcslltsw pprfshltql hprhqrilqq qqhsqtpspp akkpwsqqpd pyanlmtrke
      121 kdwvikvqmv qlqsakprld dyyyqeyyqk lekkqadeel lgrrnrvesl klvtpyipka
      181 eayesvvrie gslgqvavst cfsprraida vphgtqeqdi eaassqrlrv lyriekmflq
      241 lleieegwky rppppcfseq qsnqveklfq tlktqeqnnl eeaadgflqv lsvrkgkalv
      301 arllpflpqd qavtillait hhlpllvrrd vadqalqmlf kplgkcishl tlhellqglq
      361 gltllppgss erpvtvvlqn qdrhggsdcl gdspnaysls grtpsfpqqp tspvlsprgq
      421 tigsaaggqd gvcldllicl fwntcmweve ssdtsyidyv yrdpeslktf lmplyigepf
      481 pifisflqks k
//
LOCUS       XP_011519645             481 aa            linear   PRI 05-AUG-2025
DEFINITION  protein PAT1 homolog 2 isoform X6 [Homo sapiens].
ACCESSION   XP_011519645
VERSION     XP_011519645.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521343.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..481
                     /product="protein PAT1 homolog 2 isoform X6"
                     /calculated_mol_wt=54430
     Region          <179..>329
                     /region_name="PAT1"
                     /note="Topoisomerase II-associated protein PAT1;
                     pfam09770"
                     /db_xref="CDD:401645"
     CDS             1..481
                     /gene="PATL2"
                     /gene_synonym="hPat1a; OOMD4; OZEMA4; Pat1a"
                     /coded_by="XM_011521343.4:642..2087"
                     /db_xref="GeneID:197135"
                     /db_xref="HGNC:HGNC:33630"
                     /db_xref="MIM:614661"
ORIGIN      
        1 mlehlvlllp pttsktqtld ylspipfwpt fpstsspaqh fgprlpspdp tlfcslltsw
       61 pprfshltql hprhqrilqq qqhsqtpspp akkpwsqqpd pyanlmtrke kdwvikvqmv
      121 qlqsakprld dyyyqeyyqk lekkqadeel lgrrnrvesl klvtpyipka eayesvvrie
      181 gslgqvavst cfsprraida vphgtqeqdi eaassqrlrv lyriekmflq lleieegwky
      241 rppppcfseq qsnqveklfq tlktqeqnnl eeaadgflqv lsvrkgkalv arllpflpqd
      301 qavtillait hhlpllvrrd vadqalqmlf kplgkcishl tlhellqglq gltllppgss
      361 erpvtvvlqn qdrhggsdcl gdspnaysls grtpsfpqqp tspvlsprgq tigsaaggqd
      421 gvcldllicl fwntcmweve ssdtsyidyv yrdpeslktf lmplyigepf pifisflqks
      481 k
//
LOCUS       XP_011519646             481 aa            linear   PRI 05-AUG-2025
DEFINITION  protein PAT1 homolog 2 isoform X6 [Homo sapiens].
ACCESSION   XP_011519646
VERSION     XP_011519646.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521344.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..481
                     /product="protein PAT1 homolog 2 isoform X6"
                     /calculated_mol_wt=54430
     Region          <179..>329
                     /region_name="PAT1"
                     /note="Topoisomerase II-associated protein PAT1;
                     pfam09770"
                     /db_xref="CDD:401645"
     CDS             1..481
                     /gene="PATL2"
                     /gene_synonym="hPat1a; OOMD4; OZEMA4; Pat1a"
                     /coded_by="XM_011521344.4:157..1602"
                     /db_xref="GeneID:197135"
                     /db_xref="HGNC:HGNC:33630"
                     /db_xref="MIM:614661"
ORIGIN      
        1 mlehlvlllp pttsktqtld ylspipfwpt fpstsspaqh fgprlpspdp tlfcslltsw
       61 pprfshltql hprhqrilqq qqhsqtpspp akkpwsqqpd pyanlmtrke kdwvikvqmv
      121 qlqsakprld dyyyqeyyqk lekkqadeel lgrrnrvesl klvtpyipka eayesvvrie
      181 gslgqvavst cfsprraida vphgtqeqdi eaassqrlrv lyriekmflq lleieegwky
      241 rppppcfseq qsnqveklfq tlktqeqnnl eeaadgflqv lsvrkgkalv arllpflpqd
      301 qavtillait hhlpllvrrd vadqalqmlf kplgkcishl tlhellqglq gltllppgss
      361 erpvtvvlqn qdrhggsdcl gdspnaysls grtpsfpqqp tspvlsprgq tigsaaggqd
      421 gvcldllicl fwntcmweve ssdtsyidyv yrdpeslktf lmplyigepf pifisflqks
      481 k
//
LOCUS       XP_011519647             478 aa            linear   PRI 05-AUG-2025
DEFINITION  protein PAT1 homolog 2 isoform X7 [Homo sapiens].
ACCESSION   XP_011519647
VERSION     XP_011519647.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521345.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..478
                     /product="protein PAT1 homolog 2 isoform X7"
                     /calculated_mol_wt=54142
     Region          <176..>326
                     /region_name="PAT1"
                     /note="Topoisomerase II-associated protein PAT1;
                     pfam09770"
                     /db_xref="CDD:401645"
     CDS             1..478
                     /gene="PATL2"
                     /gene_synonym="hPat1a; OOMD4; OZEMA4; Pat1a"
                     /coded_by="XM_011521345.4:613..2049"
                     /db_xref="GeneID:197135"
                     /db_xref="HGNC:HGNC:33630"
                     /db_xref="MIM:614661"
ORIGIN      
        1 mlgmslaslh flwqtldyls pipfwptfps tsspaqhfgp rlpspdptlf cslltswppr
       61 fshltqlhpr hqrilqqqqh sqtpsppakk pwsqqpdpya nlmtrkekdw vikvqmvqlq
      121 sakprlddyy yqeyyqklek kqadeellgr rnrveslklv tpyipkaeay esvvriegsl
      181 gqvavstcfs prraidavph gtqeqdieaa ssqrlrvlyr iekmflqlle ieegwkyrpp
      241 ppcfseqqsn qveklfqtlk tqeqnnleea adgflqvlsv rkgkalvarl lpflpqdqav
      301 tillaithhl pllvrrdvad qalqmlfkpl gkcishltlh ellqglqglt llppgsserp
      361 vtvvlqnqdr hggsdclgds pnayslsgrt psfpqqptsp vlsprgqtig saaggqdgvc
      421 ldlliclfwn tcmwevessd tsyidyvyrd peslktflmp lyigepfpif isflqksk
//
LOCUS       XP_011519648             458 aa            linear   PRI 05-AUG-2025
DEFINITION  protein PAT1 homolog 2 isoform X8 [Homo sapiens].
ACCESSION   XP_011519648
VERSION     XP_011519648.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521346.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Jun 6, 2016 this sequence version replaced XP_011519648.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..458
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..458
                     /product="protein PAT1 homolog 2 isoform X8"
                     /calculated_mol_wt=51001
     Region          <156..>306
                     /region_name="PAT1"
                     /note="Topoisomerase II-associated protein PAT1;
                     pfam09770"
                     /db_xref="CDD:401645"
     CDS             1..458
                     /gene="PATL2"
                     /gene_synonym="hPat1a; OOMD4; OZEMA4; Pat1a"
                     /coded_by="XM_011521346.3:959..2335"
                     /db_xref="GeneID:197135"
                     /db_xref="HGNC:HGNC:33630"
                     /db_xref="MIM:614661"
ORIGIN      
        1 mnnlnrkdsn sqvvylpeag navsledtak kevhqpakmn clegpgktcg plaseeelvs
       61 acqlekeeen egeeeeeeed eedldpdldp dleeeendlg dpavlgavhn tqeyyqklek
      121 kqadeellgr rnrveslklv tpyipkaeay esvvriegsl gqvavstcfs prraidavph
      181 gtqeqdieaa ssqrlrvlyr iekmflqlle ieegwkyrpp ppcfseqqsn qveklfqtlk
      241 tqeqnnleea adgflqvlsv rkgkalvarl lpflpqdqav tillaithhl pllvrrdvad
      301 qalqmlfkpl gkcishltlh ellqglqglt llppgsserp vtvvlqnqdr hggsdclgds
      361 pnayslsgrt psfpqqptsp vlsprgqtig saaggqdgvc ldlliclfwn tcmwevessd
      421 tsyidyvyrd peslktflmp lyigepfpif isflqksk
//
LOCUS       XP_047288188             376 aa            linear   PRI 05-AUG-2025
DEFINITION  protein PAT1 homolog 2 isoform X9 [Homo sapiens].
ACCESSION   XP_047288188
VERSION     XP_047288188.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432232.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..376
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..376
                     /product="protein PAT1 homolog 2 isoform X9"
                     /calculated_mol_wt=42453
     Region          <74..>224
                     /region_name="PAT1"
                     /note="Topoisomerase II-associated protein PAT1;
                     pfam09770"
                     /db_xref="CDD:401645"
     CDS             1..376
                     /gene="PATL2"
                     /gene_synonym="hPat1a; OOMD4; OZEMA4; Pat1a"
                     /coded_by="XM_047432232.1:186..1316"
                     /db_xref="GeneID:197135"
                     /db_xref="HGNC:HGNC:33630"
                     /db_xref="MIM:614661"
ORIGIN      
        1 mtrkekdwvi kvqmvqlqsa kprlddyyyq eyyqklekkq adeellgrrn rveslklvtp
       61 yipkaeayes vvriegslgq vavstcfspr raidavphgt qeqdieaass qrlrvlyrie
      121 kmflqlleie egwkyrpppp cfseqqsnqv eklfqtlktq eqnnleeaad gflqvlsvrk
      181 gkalvarllp flpqdqavti llaithhlpl lvrrdvadqa lqmlfkplgk cishltlhel
      241 lqglqgltll ppgsserpvt vvlqnqdrhg gsdclgdspn ayslsgrtps fpqqptspvl
      301 sprgqtigsa aggqdgvcld lliclfwntc mwevessdts yidyvyrdpe slktflmply
      361 igepfpifis flqksk
//
LOCUS       XP_011519652             721 aa            linear   PRI 05-AUG-2025
DEFINITION  protein 4.2 isoform X1 [Homo sapiens].
ACCESSION   XP_011519652
VERSION     XP_011519652.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521350.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..721
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..721
                     /product="protein 4.2 isoform X1"
                     /calculated_mol_wt=79797
     Region          38..154
                     /region_name="Transglut_N"
                     /note="Transglutaminase family; pfam00868"
                     /db_xref="CDD:459971"
     Region          291..382
                     /region_name="TGc"
                     /note="Transglutaminase/protease-like homologues;
                     smart00460"
                     /db_xref="CDD:214673"
     Region          505..610
                     /region_name="Transglut_C"
                     /note="Transglutaminase family, C-terminal ig like domain;
                     pfam00927"
                     /db_xref="CDD:460002"
     Region          618..716
                     /region_name="Transglut_C"
                     /note="Transglutaminase family, C-terminal ig like domain;
                     pfam00927"
                     /db_xref="CDD:460002"
     CDS             1..721
                     /gene="EPB42"
                     /gene_synonym="PA; SPH5"
                     /coded_by="XM_011521350.3:642..2807"
                     /db_xref="GeneID:2038"
                     /db_xref="HGNC:HGNC:3381"
                     /db_xref="MIM:177070"
ORIGIN      
        1 mgqgepsqrs tglaglyaap aaspvfikgs gmdalgiksc dfqaarnnee hhtkalssrr
       61 lfvrrgqpft iilyfrapvr aflpalkkva ltaqtgeqps kinrtqatfp isslgdrkww
      121 savveerdaq swtisvttpa davighysll lqvsgrkqll lgqftllfnp wnredavflk
      181 neaqrmeyll nqngliylgt adciqaeswd fgqfegdvid lslrllskdk qvekwsqpvh
      241 varvlgallh flkeqrvlpt pqtqatqega llnkrrgsvp ilrqwltgrg rpvydgqawv
      301 laavactvlr clgiparvvt tfasaqgtgg rllideyyne eglqngegqr griwifqtst
      361 ecwmtrpalp qgydgwqilh psapngggvl gscdlvpvra vkegtlgltp avsdlfaain
      421 ascvvwkcce dgtleltdsn tkyvgnnist kgvgsdrced itqnykypeg slqekevler
      481 vekekmerek dngirppsle tasplylllk apsslplrgd aqisvtlvnh seqekavqla
      541 igvqavhyng vlaaklwrkk lhltlsanle kiitiglffs nfernppent flrltamath
      601 sesnlscfaq ediaicrphl aikmpekaeq yqpltasvsl qnsldapmed cvisilgrgl
      661 ihrersyrfr svwpentmca kfqftpthvg lqrltvevdc nmfqnltnyk svtvvapels
      721 a
//
LOCUS       XP_011519653             721 aa            linear   PRI 05-AUG-2025
DEFINITION  protein 4.2 isoform X1 [Homo sapiens].
ACCESSION   XP_011519653
VERSION     XP_011519653.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521351.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..721
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..721
                     /product="protein 4.2 isoform X1"
                     /calculated_mol_wt=79797
     Region          38..154
                     /region_name="Transglut_N"
                     /note="Transglutaminase family; pfam00868"
                     /db_xref="CDD:459971"
     Region          291..382
                     /region_name="TGc"
                     /note="Transglutaminase/protease-like homologues;
                     smart00460"
                     /db_xref="CDD:214673"
     Region          505..610
                     /region_name="Transglut_C"
                     /note="Transglutaminase family, C-terminal ig like domain;
                     pfam00927"
                     /db_xref="CDD:460002"
     Region          618..716
                     /region_name="Transglut_C"
                     /note="Transglutaminase family, C-terminal ig like domain;
                     pfam00927"
                     /db_xref="CDD:460002"
     CDS             1..721
                     /gene="EPB42"
                     /gene_synonym="PA; SPH5"
                     /coded_by="XM_011521351.3:504..2669"
                     /db_xref="GeneID:2038"
                     /db_xref="HGNC:HGNC:3381"
                     /db_xref="MIM:177070"
ORIGIN      
        1 mgqgepsqrs tglaglyaap aaspvfikgs gmdalgiksc dfqaarnnee hhtkalssrr
       61 lfvrrgqpft iilyfrapvr aflpalkkva ltaqtgeqps kinrtqatfp isslgdrkww
      121 savveerdaq swtisvttpa davighysll lqvsgrkqll lgqftllfnp wnredavflk
      181 neaqrmeyll nqngliylgt adciqaeswd fgqfegdvid lslrllskdk qvekwsqpvh
      241 varvlgallh flkeqrvlpt pqtqatqega llnkrrgsvp ilrqwltgrg rpvydgqawv
      301 laavactvlr clgiparvvt tfasaqgtgg rllideyyne eglqngegqr griwifqtst
      361 ecwmtrpalp qgydgwqilh psapngggvl gscdlvpvra vkegtlgltp avsdlfaain
      421 ascvvwkcce dgtleltdsn tkyvgnnist kgvgsdrced itqnykypeg slqekevler
      481 vekekmerek dngirppsle tasplylllk apsslplrgd aqisvtlvnh seqekavqla
      541 igvqavhyng vlaaklwrkk lhltlsanle kiitiglffs nfernppent flrltamath
      601 sesnlscfaq ediaicrphl aikmpekaeq yqpltasvsl qnsldapmed cvisilgrgl
      661 ihrersyrfr svwpentmca kfqftpthvg lqrltvevdc nmfqnltnyk svtvvapels
      721 a
//
LOCUS       XP_011519654             709 aa            linear   PRI 05-AUG-2025
DEFINITION  protein 4.2 isoform X2 [Homo sapiens].
ACCESSION   XP_011519654
VERSION     XP_011519654.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521352.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..709
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..709
                     /product="protein 4.2 isoform X2"
                     /calculated_mol_wt=78322
     Region          38..154
                     /region_name="Transglut_N"
                     /note="Transglutaminase family; pfam00868"
                     /db_xref="CDD:459971"
     Region          279..370
                     /region_name="TGc"
                     /note="Transglutaminase/protease-like homologues;
                     smart00460"
                     /db_xref="CDD:214673"
     Region          493..598
                     /region_name="Transglut_C"
                     /note="Transglutaminase family, C-terminal ig like domain;
                     pfam00927"
                     /db_xref="CDD:460002"
     Region          606..704
                     /region_name="Transglut_C"
                     /note="Transglutaminase family, C-terminal ig like domain;
                     pfam00927"
                     /db_xref="CDD:460002"
     CDS             1..709
                     /gene="EPB42"
                     /gene_synonym="PA; SPH5"
                     /coded_by="XM_011521352.3:194..2323"
                     /db_xref="GeneID:2038"
                     /db_xref="HGNC:HGNC:3381"
                     /db_xref="MIM:177070"
ORIGIN      
        1 mgqgepsqrs tglaglyaap aaspvfikgs gmdalgiksc dfqaarnnee hhtkalssrr
       61 lfvrrgqpft iilyfrapvr aflpalkkva ltaqtgeqps kinrtqatfp isslgdrkww
      121 savveerdaq swtisvttpa davighysll lqvsgrkqll ledavflkne aqrmeyllnq
      181 ngliylgtad ciqaeswdfg qfegdvidls lrllskdkqv ekwsqpvhva rvlgallhfl
      241 keqrvlptpq tqatqegall nkrrgsvpil rqwltgrgrp vydgqawvla avactvlrcl
      301 giparvvttf asaqgtggrl lideyyneeg lqngegqrgr iwifqtstec wmtrpalpqg
      361 ydgwqilhps apngggvlgs cdlvpvravk egtlgltpav sdlfaainas cvvwkccedg
      421 tleltdsntk yvgnnistkg vgsdrcedit qnykypegsl qekevlerve kekmerekdn
      481 girppsleta splylllkap sslplrgdaq isvtlvnhse qekavqlaig vqavhyngvl
      541 aaklwrkklh ltlsanleki itiglffsnf ernppentfl rltamathse snlscfaqed
      601 iaicrphlai kmpekaeqyq pltasvslqn sldapmedcv isilgrglih rersyrfrsv
      661 wpentmcakf qftpthvglq rltvevdcnm fqnltnyksv tvvapelsa
//
LOCUS       XP_011519655             686 aa            linear   PRI 05-AUG-2025
DEFINITION  protein 4.2 isoform X3 [Homo sapiens].
ACCESSION   XP_011519655
VERSION     XP_011519655.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521353.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..686
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..686
                     /product="protein 4.2 isoform X3"
                     /calculated_mol_wt=75867
     Region          38..154
                     /region_name="Transglut_N"
                     /note="Transglutaminase family; pfam00868"
                     /db_xref="CDD:459971"
     Region          256..347
                     /region_name="TGc"
                     /note="Transglutaminase/protease-like homologues;
                     smart00460"
                     /db_xref="CDD:214673"
     Region          470..575
                     /region_name="Transglut_C"
                     /note="Transglutaminase family, C-terminal ig like domain;
                     pfam00927"
                     /db_xref="CDD:460002"
     Region          583..681
                     /region_name="Transglut_C"
                     /note="Transglutaminase family, C-terminal ig like domain;
                     pfam00927"
                     /db_xref="CDD:460002"
     CDS             1..686
                     /gene="EPB42"
                     /gene_synonym="PA; SPH5"
                     /coded_by="XM_011521353.3:194..2254"
                     /db_xref="GeneID:2038"
                     /db_xref="HGNC:HGNC:3381"
                     /db_xref="MIM:177070"
ORIGIN      
        1 mgqgepsqrs tglaglyaap aaspvfikgs gmdalgiksc dfqaarnnee hhtkalssrr
       61 lfvrrgqpft iilyfrapvr aflpalkkva ltaqtgeqps kinrtqatfp isslgdrkww
      121 savveerdaq swtisvttpa davighysll lqvsgrkqll lgqftllfnp wnredavflk
      181 neaqrmeyll nqngliylgt adciqaeswd fgqlhflkeq rvlptpqtqa tqegallnkr
      241 rgsvpilrqw ltgrgrpvyd gqawvlaava ctvlrclgip arvvttfasa qgtggrllid
      301 eyyneeglqn gegqrgriwi fqtstecwmt rpalpqgydg wqilhpsapn gggvlgscdl
      361 vpvravkegt lgltpavsdl faainascvv wkccedgtle ltdsntkyvg nnistkgvgs
      421 drceditqny kypegslqek evlervekek merekdngir ppsletaspl ylllkapssl
      481 plrgdaqisv tlvnhseqek avqlaigvqa vhyngvlaak lwrkklhltl sanlekiiti
      541 glffsnfern ppentflrlt amathsesnl scfaqediai crphlaikmp ekaeqyqplt
      601 asvslqnsld apmedcvisi lgrglihrer syrfrsvwpe ntmcakfqft pthvglqrlt
      661 vevdcnmfqn ltnyksvtvv apelsa
//
LOCUS       XP_005254282             656 aa            linear   PRI 05-AUG-2025
DEFINITION  protein 4.2 isoform X4 [Homo sapiens].
ACCESSION   XP_005254282
VERSION     XP_005254282.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254225.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..656
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..656
                     /product="protein 4.2 isoform X4"
                     /calculated_mol_wt=72949
     Region          8..124
                     /region_name="Transglut_N"
                     /note="Transglutaminase family; pfam00868"
                     /db_xref="CDD:459971"
     Region          226..317
                     /region_name="TGc"
                     /note="Transglutaminase/protease-like homologues;
                     smart00460"
                     /db_xref="CDD:214673"
     Region          440..545
                     /region_name="Transglut_C"
                     /note="Transglutaminase family, C-terminal ig like domain;
                     pfam00927"
                     /db_xref="CDD:460002"
     Region          553..651
                     /region_name="Transglut_C"
                     /note="Transglutaminase family, C-terminal ig like domain;
                     pfam00927"
                     /db_xref="CDD:460002"
     CDS             1..656
                     /gene="EPB42"
                     /gene_synonym="PA; SPH5"
                     /coded_by="XM_005254225.2:194..2164"
                     /db_xref="GeneID:2038"
                     /db_xref="HGNC:HGNC:3381"
                     /db_xref="MIM:177070"
ORIGIN      
        1 mgqalgiksc dfqaarnnee hhtkalssrr lfvrrgqpft iilyfrapvr aflpalkkva
       61 ltaqtgeqps kinrtqatfp isslgdrkww savveerdaq swtisvttpa davighysll
      121 lqvsgrkqll lgqftllfnp wnredavflk neaqrmeyll nqngliylgt adciqaeswd
      181 fgqlhflkeq rvlptpqtqa tqegallnkr rgsvpilrqw ltgrgrpvyd gqawvlaava
      241 ctvlrclgip arvvttfasa qgtggrllid eyyneeglqn gegqrgriwi fqtstecwmt
      301 rpalpqgydg wqilhpsapn gggvlgscdl vpvravkegt lgltpavsdl faainascvv
      361 wkccedgtle ltdsntkyvg nnistkgvgs drceditqny kypegslqek evlervekek
      421 merekdngir ppsletaspl ylllkapssl plrgdaqisv tlvnhseqek avqlaigvqa
      481 vhyngvlaak lwrkklhltl sanlekiiti glffsnfern ppentflrlt amathsesnl
      541 scfaqediai crphlaikmp ekaeqyqplt asvslqnsld apmedcvisi lgrglihrer
      601 syrfrsvwpe ntmcakfqft pthvglqrlt vevdcnmfqn ltnyksvtvv apelsa
//
LOCUS       XP_011519656             536 aa            linear   PRI 05-AUG-2025
DEFINITION  protein 4.2 isoform X5 [Homo sapiens].
ACCESSION   XP_011519656
VERSION     XP_011519656.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521354.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..536
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..536
                     /product="protein 4.2 isoform X5"
                     /calculated_mol_wt=59357
     Region          106..197
                     /region_name="TGc"
                     /note="Transglutaminase/protease-like homologues;
                     smart00460"
                     /db_xref="CDD:214673"
     Region          320..425
                     /region_name="Transglut_C"
                     /note="Transglutaminase family, C-terminal ig like domain;
                     pfam00927"
                     /db_xref="CDD:460002"
     Region          433..531
                     /region_name="Transglut_C"
                     /note="Transglutaminase family, C-terminal ig like domain;
                     pfam00927"
                     /db_xref="CDD:460002"
     CDS             1..536
                     /gene="EPB42"
                     /gene_synonym="PA; SPH5"
                     /coded_by="XM_011521354.2:170..1780"
                     /db_xref="GeneID:2038"
                     /db_xref="HGNC:HGNC:3381"
                     /db_xref="MIM:177070"
ORIGIN      
        1 meyllnqngl iylgtadciq aeswdfgqfe gdvidlslrl lskdkqvekw sqpvhvarvl
       61 gallhflkeq rvlptpqtqa tqegallnkr rgsvpilrqw ltgrgrpvyd gqawvlaava
      121 ctvlrclgip arvvttfasa qgtggrllid eyyneeglqn gegqrgriwi fqtstecwmt
      181 rpalpqgydg wqilhpsapn gggvlgscdl vpvravkegt lgltpavsdl faainascvv
      241 wkccedgtle ltdsntkyvg nnistkgvgs drceditqny kypegslqek evlervekek
      301 merekdngir ppsletaspl ylllkapssl plrgdaqisv tlvnhseqek avqlaigvqa
      361 vhyngvlaak lwrkklhltl sanlekiiti glffsnfern ppentflrlt amathsesnl
      421 scfaqediai crphlaikmp ekaeqyqplt asvslqnsld apmedcvisi lgrglihrer
      481 syrfrsvwpe ntmcakfqft pthvglqrlt vevdcnmfqn ltnyksvtvv apelsa
//
LOCUS       XP_011519657             394 aa            linear   PRI 05-AUG-2025
DEFINITION  ceramide synthase 3 isoform X1 [Homo sapiens].
ACCESSION   XP_011519657
VERSION     XP_011519657.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521355.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..394
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..394
                     /product="ceramide synthase 3 isoform X1"
                     /calculated_mol_wt=47451
     Region          <93..139
                     /region_name="homeodomain"
                     /note="Homeodomain; DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; cd00086"
                     /db_xref="CDD:238039"
     Region          142..335
                     /region_name="TRAM_LAG1_CLN8"
                     /note="TLC domain; pfam03798"
                     /db_xref="CDD:461055"
     CDS             1..394
                     /gene="CERS3"
                     /gene_synonym="ARCI9; LASS3"
                     /coded_by="XM_011521355.3:624..1808"
                     /db_xref="GeneID:204219"
                     /db_xref="HGNC:HGNC:23752"
                     /db_xref="MIM:615276"
ORIGIN      
        1 mlhttarraa rmfwtfkewf wlerfwlppt ikwsdledhd glvfvkpshl yvtipyafll
       61 liirrvfekf vasplaksfg iketvrkvtp ntvlenffkh strqplqtdi yglakkcnlt
      121 erqverwfrs rrnqerpsrl kkfqeacwrf afylmitvag iaflydkpwl ydlwevwngy
      181 pkqpllpsqy wyyilemsfy wsllfrlgfd vkrkdflahi ihhlaaislm sfswcanyir
      241 sgtlvmivhd vadiwlesak mfsyagwtqt cntlffifst iffisrlivf pfwilyctli
      301 lpmyhlepff syiflnlqlm ilqvlhlywg yyilkmlnrc ifmksiqdvr sddedyeeee
      361 eeeeeeatkg kemdclkngl raerhlipng qhgh
//
LOCUS       XP_016877491             394 aa            linear   PRI 05-AUG-2025
DEFINITION  ceramide synthase 3 isoform X1 [Homo sapiens].
ACCESSION   XP_016877491
VERSION     XP_016877491.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022002.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..394
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..394
                     /product="ceramide synthase 3 isoform X1"
                     /calculated_mol_wt=47451
     Region          <93..139
                     /region_name="homeodomain"
                     /note="Homeodomain; DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; cd00086"
                     /db_xref="CDD:238039"
     Region          142..335
                     /region_name="TRAM_LAG1_CLN8"
                     /note="TLC domain; pfam03798"
                     /db_xref="CDD:461055"
     CDS             1..394
                     /gene="CERS3"
                     /gene_synonym="ARCI9; LASS3"
                     /coded_by="XM_017022002.2:639..1823"
                     /db_xref="GeneID:204219"
                     /db_xref="HGNC:HGNC:23752"
                     /db_xref="MIM:615276"
ORIGIN      
        1 mlhttarraa rmfwtfkewf wlerfwlppt ikwsdledhd glvfvkpshl yvtipyafll
       61 liirrvfekf vasplaksfg iketvrkvtp ntvlenffkh strqplqtdi yglakkcnlt
      121 erqverwfrs rrnqerpsrl kkfqeacwrf afylmitvag iaflydkpwl ydlwevwngy
      181 pkqpllpsqy wyyilemsfy wsllfrlgfd vkrkdflahi ihhlaaislm sfswcanyir
      241 sgtlvmivhd vadiwlesak mfsyagwtqt cntlffifst iffisrlivf pfwilyctli
      301 lpmyhlepff syiflnlqlm ilqvlhlywg yyilkmlnrc ifmksiqdvr sddedyeeee
      361 eeeeeeatkg kemdclkngl raerhlipng qhgh
//
LOCUS       XP_011519659             394 aa            linear   PRI 05-AUG-2025
DEFINITION  ceramide synthase 3 isoform X1 [Homo sapiens].
ACCESSION   XP_011519659
VERSION     XP_011519659.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521357.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..394
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..394
                     /product="ceramide synthase 3 isoform X1"
                     /calculated_mol_wt=47451
     Region          <93..139
                     /region_name="homeodomain"
                     /note="Homeodomain; DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; cd00086"
                     /db_xref="CDD:238039"
     Region          142..335
                     /region_name="TRAM_LAG1_CLN8"
                     /note="TLC domain; pfam03798"
                     /db_xref="CDD:461055"
     CDS             1..394
                     /gene="CERS3"
                     /gene_synonym="ARCI9; LASS3"
                     /coded_by="XM_011521357.3:498..1682"
                     /db_xref="GeneID:204219"
                     /db_xref="HGNC:HGNC:23752"
                     /db_xref="MIM:615276"
ORIGIN      
        1 mlhttarraa rmfwtfkewf wlerfwlppt ikwsdledhd glvfvkpshl yvtipyafll
       61 liirrvfekf vasplaksfg iketvrkvtp ntvlenffkh strqplqtdi yglakkcnlt
      121 erqverwfrs rrnqerpsrl kkfqeacwrf afylmitvag iaflydkpwl ydlwevwngy
      181 pkqpllpsqy wyyilemsfy wsllfrlgfd vkrkdflahi ihhlaaislm sfswcanyir
      241 sgtlvmivhd vadiwlesak mfsyagwtqt cntlffifst iffisrlivf pfwilyctli
      301 lpmyhlepff syiflnlqlm ilqvlhlywg yyilkmlnrc ifmksiqdvr sddedyeeee
      361 eeeeeeatkg kemdclkngl raerhlipng qhgh
//
LOCUS       XP_016877493             383 aa            linear   PRI 05-AUG-2025
DEFINITION  ceramide synthase 3 isoform X2 [Homo sapiens].
ACCESSION   XP_016877493
VERSION     XP_016877493.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022004.2
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 1% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..383
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..383
                     /product="ceramide synthase 3 isoform X2"
                     /calculated_mol_wt=46185
     Region          <82..128
                     /region_name="homeodomain"
                     /note="Homeodomain; DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; cd00086"
                     /db_xref="CDD:238039"
     Region          131..324
                     /region_name="TRAM_LAG1_CLN8"
                     /note="TLC domain; pfam03798"
                     /db_xref="CDD:461055"
     CDS             1..383
                     /gene="CERS3"
                     /gene_synonym="ARCI9; LASS3"
                     /coded_by="XM_017022004.2:265..1416"
                     /db_xref="GeneID:204219"
                     /db_xref="HGNC:HGNC:23752"
                     /db_xref="MIM:615276"
ORIGIN      
        1 mfwtfkewfw lerfwlppti kwsdledhdg lvfvkpshly vtipyaflll iirrvfekfv
       61 asplaksfgi ketvrkvtpn tvlenffkhs trqplqtdiy glakkcnlte rqverwfrsr
      121 rnqerpsrlk kfqeacwrfa fylmitvagi aflydkpwly dlwevwngyp kqpllpsqyw
      181 yyilemsfyw sllfrlgfdv krkdflahii hhlaaislms fswcanyirs gtlvmivhdv
      241 adiwlesakm fsyagwtqtc ntlffifsti ffisrlivfp fwilyctlil pmyhlepffs
      301 yiflnlqlmi lqvlhlywgy yilkmlnrci fmksiqdvrs ddedyeeeee eeeeeatkgk
      361 emdclknglr aerhlipngq hgh
//
LOCUS       XP_016877494             822 aa            linear   PRI 05-AUG-2025
DEFINITION  tyrosine-protein kinase Fes/Fps isoform X1 [Homo sapiens].
ACCESSION   XP_016877494
VERSION     XP_016877494.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022005.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..822
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..822
                     /product="tyrosine-protein kinase Fes/Fps isoform X1"
                     /calculated_mol_wt=93366
     Region          7..239
                     /region_name="F-BAR_Fes"
                     /note="The F-BAR (FES-CIP4 Homology and
                     Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma)
                     tyrosine kinase; cd07685"
                     /db_xref="CDD:153369"
     Site            order(12,15,22,25..26,29,32..33,36..37,40,44,47,51,79,82,
                     169,173,198,206,209,212..213,216,220,223,227,231,234..235,
                     238)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:153369"
     Region          453..537
                     /region_name="SH2_Fps_family"
                     /note="Src homology 2 (SH2) domain found in feline
                     sarcoma, Fujinami poultry sarcoma, and fes-related
                     (Fes/Fps/Fer) proteins; cd10361"
                     /db_xref="CDD:198224"
     Site            order(467,483,503,505)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198224"
     Site            order(504,530)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198224"
     Region          564..815
                     /region_name="PTKc_Fes"
                     /note="Catalytic domain of the Protein Tyrosine Kinase,
                     Fes; cd05084"
                     /db_xref="CDD:270667"
     Site            order(567..569,575,588,590,607,636..639,642..643,683,
                     687..688,690,700..701,704,719..724,726,732,766,770)
                     /site_type="active"
                     /db_xref="CDD:270667"
     Site            order(567..569,575,588,590,607,636..639,642..643,687..688,
                     690,700..701)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270667"
     Site            order(683,687..688,704,719..724,726,732,766,770)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270667"
     Site            700..725
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270667"
     CDS             1..822
                     /gene="FES"
                     /gene_synonym="FPS"
                     /coded_by="XM_017022005.2:46..2514"
                     /db_xref="GeneID:2242"
                     /db_xref="HGNC:HGNC:3657"
                     /db_xref="MIM:190030"
ORIGIN      
        1 mgfsselcsp qghgvlqqmq eaelrllegm rkwmaqrvks dreyagllhh mslqdsggqs
       61 raispdspis qswaeitsqt eglsrllrqh aedlnsgpls klsllirerq qlrktyseqw
      121 qqlqqeltkt hsqdieklks qyralardsa qakrkyqeas kdkdrdkakd kyvrslwklf
      181 ahhnryvlgv raaqlhhqhh hqlllpgllr slqdlheema cilkeilqey leisslvqde
      241 vvaihremaa aaariqpeae yqgflrqygs apdvppcvtf deslleegep lepgelqlne
      301 ltvesvqhtl tsvtdelava temvfrrqem vtqlqqelrn eeenthprer vqllgkrqvl
      361 qealqglqva lcsqaklqaq qellqtkleh lgpgepppvl llqddrhsts sseqereggr
      421 tptleilksh isgifrpkfs lppplqlipe vqkplheqlw yhgaipraev aellvhsgdf
      481 lvresqgkqe yvlsvlwdgl prhfiiqsld nlyrlegegf psipllidhl lstqqpltkk
      541 sgvvlhravp kdkwvlnhed lvlgeqigrg nfgevfsgrl radntlvavk scretlppdl
      601 kakflqeari lkqyshpniv rligvctqkq piyivmelvq ggdfltflrt egarlrvktl
      661 lqmvgdaaag meyleskcci hrdlaarncl vteknvlkis dfgmsreead gvyaasgglr
      721 qvpvkwtape alnygrysse sdvwsfgill wetfslgasp ypnlsnqqtr efvekggrlp
      781 cpelcpdavf rlmeqcwaye pgqrpsfsti yqelqsirkr hr
//
LOCUS       XP_016877495             764 aa            linear   PRI 05-AUG-2025
DEFINITION  tyrosine-protein kinase Fes/Fps isoform X2 [Homo sapiens].
ACCESSION   XP_016877495
VERSION     XP_016877495.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022006.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..764
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..764
                     /product="tyrosine-protein kinase Fes/Fps isoform X2"
                     /calculated_mol_wt=86532
     Region          7..181
                     /region_name="BAR"
                     /note="The Bin/Amphiphysin/Rvs (BAR) domain, a
                     dimerization module that binds membranes and detects
                     membrane curvature; cl12013"
                     /db_xref="CDD:472257"
     Site            order(12,15..16,20,22..23,26..27,29..30,40..41,43..44,
                     47..48,50..51,54,136,139..140,142,148,151..152,154..155,
                     158..159,162..163,165..166,169..170,172..173)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:153369"
     Region          395..479
                     /region_name="SH2_Fps_family"
                     /note="Src homology 2 (SH2) domain found in feline
                     sarcoma, Fujinami poultry sarcoma, and fes-related
                     (Fes/Fps/Fer) proteins; cd10361"
                     /db_xref="CDD:198224"
     Site            order(409,425,445,447)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198224"
     Site            order(446,472)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198224"
     Region          506..757
                     /region_name="PTKc_Fes"
                     /note="Catalytic domain of the Protein Tyrosine Kinase,
                     Fes; cd05084"
                     /db_xref="CDD:270667"
     Site            order(509..511,517,530,532,549,578..581,584..585,625,
                     629..630,632,642..643,646,661..666,668,674,708,712)
                     /site_type="active"
                     /db_xref="CDD:270667"
     Site            order(509..511,517,530,532,549,578..581,584..585,629..630,
                     632,642..643)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270667"
     Site            order(625,629..630,646,661..666,668,674,708,712)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270667"
     Site            642..667
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270667"
     CDS             1..764
                     /gene="FES"
                     /gene_synonym="FPS"
                     /coded_by="XM_017022006.2:46..2340"
                     /db_xref="GeneID:2242"
                     /db_xref="HGNC:HGNC:3657"
                     /db_xref="MIM:190030"
ORIGIN      
        1 mgfsselcsp qghgvlqqmq eaelrllegm rkwmaqrvks dreyagllhh mslqdsggqs
       61 raispdspis qthsqdiekl ksqyralard saqakrkyqe askdkdrdka kdkyvrslwk
      121 lfahhnryvl gvraaqlhhq hhhqlllpgl lrslqdlhee macilkeilq eyleisslvq
      181 devvaihrem aaaaariqpe aeyqgflrqy gsapdvppcv tfdeslleeg eplepgelql
      241 neltvesvqh tltsvtdela vatemvfrrq emvtqlqqel rneeenthpr ervqllgkrq
      301 vlqealqglq valcsqaklq aqqellqtkl ehlgpgeppp vlllqddrhs tssseqereg
      361 grtptleilk shisgifrpk fslppplqli pevqkplheq lwyhgaipra evaellvhsg
      421 dflvresqgk qeyvlsvlwd glprhfiiqs ldnlyrlege gfpsipllid hllstqqplt
      481 kksgvvlhra vpkdkwvlnh edlvlgeqig rgnfgevfsg rlradntlva vkscretlpp
      541 dlkakflqea rilkqyshpn ivrligvctq kqpiyivmel vqggdfltfl rtegarlrvk
      601 tllqmvgdaa agmeyleskc cihrdlaarn clvteknvlk isdfgmsree adgvyaasgg
      661 lrqvpvkwta pealnygrys sesdvwsfgi llwetfslga spypnlsnqq trefvekggr
      721 lpcpelcpda vfrlmeqcwa yepgqrpsfs tiyqelqsir krhr
//
LOCUS       XP_016877496             752 aa            linear   PRI 05-AUG-2025
DEFINITION  tyrosine-protein kinase Fes/Fps isoform X3 [Homo sapiens].
ACCESSION   XP_016877496
VERSION     XP_016877496.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022007.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..752
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..752
                     /product="tyrosine-protein kinase Fes/Fps isoform X3"
                     /calculated_mol_wt=85336
     Region          7..239
                     /region_name="BAR"
                     /note="The Bin/Amphiphysin/Rvs (BAR) domain, a
                     dimerization module that binds membranes and detects
                     membrane curvature; cl12013"
                     /db_xref="CDD:472257"
     Site            order(12,15..16,20,22..23,26..27,29..30,40..41,43..44,
                     47..48,50..51,54,82,85..86,194,197..198,200,206,209..210,
                     212..213,216..217,220..221,223..224,227..228,230..231)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:153369"
     Region          494..745
                     /region_name="PTKc_Fes"
                     /note="Catalytic domain of the Protein Tyrosine Kinase,
                     Fes; cd05084"
                     /db_xref="CDD:270667"
     Site            order(497..499,505,518,520,537,566..569,572..573,613,
                     617..618,620,630..631,634,649..654,656,662,696,700)
                     /site_type="active"
                     /db_xref="CDD:270667"
     Site            order(497..499,505,518,520,537,566..569,572..573,617..618,
                     620,630..631)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270667"
     Site            order(613,617..618,634,649..654,656,662,696,700)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270667"
     Site            630..655
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270667"
     CDS             1..752
                     /gene="FES"
                     /gene_synonym="FPS"
                     /coded_by="XM_017022007.2:46..2304"
                     /db_xref="GeneID:2242"
                     /db_xref="HGNC:HGNC:3657"
                     /db_xref="MIM:190030"
ORIGIN      
        1 mgfsselcsp qghgvlqqmq eaelrllegm rkwmaqrvks dreyagllhh mslqdsggqs
       61 raispdspis qswaeitsqt eglsrllrqh aedlnsgpls klsllirerq qlrktyseqw
      121 qqlqqeltkt hsqdieklks qyralardsa qakrkyqeas kdkdrdkakd kyvrslwklf
      181 ahhnryvlgv raaqlhhqhh hqlllpgllr slqdlheema cilkeilqey leisslvqde
      241 vvaihremaa aaariqpeae yqgflrqygs apdvppcvtf deslleegep lepgelqlne
      301 ltvesvqhtl tsvtdelava temvfrrqem vtqlqqelrn eeenthprer vqllgkrqvl
      361 qealqglqva lcsqaklqaq qellqtkleh lgpgepppvl llqddrhsts sseqereggr
      421 tptleilksh isgifrpkfs nlyrlegegf psipllidhl lstqqpltkk sgvvlhravp
      481 kdkwvlnhed lvlgeqigrg nfgevfsgrl radntlvavk scretlppdl kakflqeari
      541 lkqyshpniv rligvctqkq piyivmelvq ggdfltflrt egarlrvktl lqmvgdaaag
      601 meyleskcci hrdlaarncl vteknvlkis dfgmsreead gvyaasgglr qvpvkwtape
      661 alnygrysse sdvwsfgill wetfslgasp ypnlsnqqtr efvekggrlp cpelcpdavf
      721 rlmeqcwaye pgqrpsfsti yqelqsirkr hr
//
LOCUS       XP_016877497             694 aa            linear   PRI 05-AUG-2025
DEFINITION  tyrosine-protein kinase Fes/Fps isoform X4 [Homo sapiens].
ACCESSION   XP_016877497
VERSION     XP_016877497.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022008.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..694
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..694
                     /product="tyrosine-protein kinase Fes/Fps isoform X4"
                     /calculated_mol_wt=78502
     Region          7..181
                     /region_name="BAR"
                     /note="The Bin/Amphiphysin/Rvs (BAR) domain, a
                     dimerization module that binds membranes and detects
                     membrane curvature; cl12013"
                     /db_xref="CDD:472257"
     Site            order(12,15..16,20,22..23,26..27,29..30,40..41,43..44,
                     47..48,50..51,54,136,139..140,142,148,151..152,154..155,
                     158..159,162..163,165..166,169..170,172..173)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:153271"
     Region          436..687
                     /region_name="PTKc_Fes"
                     /note="Catalytic domain of the Protein Tyrosine Kinase,
                     Fes; cd05084"
                     /db_xref="CDD:270667"
     Site            order(439..441,447,460,462,479,508..511,514..515,555,
                     559..560,562,572..573,576,591..596,598,604,638,642)
                     /site_type="active"
                     /db_xref="CDD:270667"
     Site            order(439..441,447,460,462,479,508..511,514..515,559..560,
                     562,572..573)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270667"
     Site            order(555,559..560,576,591..596,598,604,638,642)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270667"
     Site            572..597
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270667"
     CDS             1..694
                     /gene="FES"
                     /gene_synonym="FPS"
                     /coded_by="XM_017022008.2:46..2130"
                     /db_xref="GeneID:2242"
                     /db_xref="HGNC:HGNC:3657"
                     /db_xref="MIM:190030"
ORIGIN      
        1 mgfsselcsp qghgvlqqmq eaelrllegm rkwmaqrvks dreyagllhh mslqdsggqs
       61 raispdspis qthsqdiekl ksqyralard saqakrkyqe askdkdrdka kdkyvrslwk
      121 lfahhnryvl gvraaqlhhq hhhqlllpgl lrslqdlhee macilkeilq eyleisslvq
      181 devvaihrem aaaaariqpe aeyqgflrqy gsapdvppcv tfdeslleeg eplepgelql
      241 neltvesvqh tltsvtdela vatemvfrrq emvtqlqqel rneeenthpr ervqllgkrq
      301 vlqealqglq valcsqaklq aqqellqtkl ehlgpgeppp vlllqddrhs tssseqereg
      361 grtptleilk shisgifrpk fsnlyrlege gfpsipllid hllstqqplt kksgvvlhra
      421 vpkdkwvlnh edlvlgeqig rgnfgevfsg rlradntlva vkscretlpp dlkakflqea
      481 rilkqyshpn ivrligvctq kqpiyivmel vqggdfltfl rtegarlrvk tllqmvgdaa
      541 agmeyleskc cihrdlaarn clvteknvlk isdfgmsree adgvyaasgg lrqvpvkwta
      601 pealnygrys sesdvwsfgi llwetfslga spypnlsnqq trefvekggr lpcpelcpda
      661 vfrlmeqcwa yepgqrpsfs tiyqelqsir krhr
//
LOCUS       XP_016877498             822 aa            linear   PRI 05-AUG-2025
DEFINITION  tyrosine-protein kinase Fes/Fps isoform X1 [Homo sapiens].
ACCESSION   XP_016877498
VERSION     XP_016877498.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022009.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..822
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..822
                     /product="tyrosine-protein kinase Fes/Fps isoform X1"
                     /calculated_mol_wt=93366
     Region          7..239
                     /region_name="F-BAR_Fes"
                     /note="The F-BAR (FES-CIP4 Homology and
                     Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma)
                     tyrosine kinase; cd07685"
                     /db_xref="CDD:153369"
     Site            order(12,15,22,25..26,29,32..33,36..37,40,44,47,51,79,82,
                     169,173,198,206,209,212..213,216,220,223,227,231,234..235,
                     238)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:153369"
     Region          453..537
                     /region_name="SH2_Fps_family"
                     /note="Src homology 2 (SH2) domain found in feline
                     sarcoma, Fujinami poultry sarcoma, and fes-related
                     (Fes/Fps/Fer) proteins; cd10361"
                     /db_xref="CDD:198224"
     Site            order(467,483,503,505)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198224"
     Site            order(504,530)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198224"
     Region          564..815
                     /region_name="PTKc_Fes"
                     /note="Catalytic domain of the Protein Tyrosine Kinase,
                     Fes; cd05084"
                     /db_xref="CDD:270667"
     Site            order(567..569,575,588,590,607,636..639,642..643,683,
                     687..688,690,700..701,704,719..724,726,732,766,770)
                     /site_type="active"
                     /db_xref="CDD:270667"
     Site            order(567..569,575,588,590,607,636..639,642..643,687..688,
                     690,700..701)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270667"
     Site            order(683,687..688,704,719..724,726,732,766,770)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270667"
     Site            700..725
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270667"
     CDS             1..822
                     /gene="FES"
                     /gene_synonym="FPS"
                     /coded_by="XM_017022009.3:146..2614"
                     /db_xref="GeneID:2242"
                     /db_xref="HGNC:HGNC:3657"
                     /db_xref="MIM:190030"
ORIGIN      
        1 mgfsselcsp qghgvlqqmq eaelrllegm rkwmaqrvks dreyagllhh mslqdsggqs
       61 raispdspis qswaeitsqt eglsrllrqh aedlnsgpls klsllirerq qlrktyseqw
      121 qqlqqeltkt hsqdieklks qyralardsa qakrkyqeas kdkdrdkakd kyvrslwklf
      181 ahhnryvlgv raaqlhhqhh hqlllpgllr slqdlheema cilkeilqey leisslvqde
      241 vvaihremaa aaariqpeae yqgflrqygs apdvppcvtf deslleegep lepgelqlne
      301 ltvesvqhtl tsvtdelava temvfrrqem vtqlqqelrn eeenthprer vqllgkrqvl
      361 qealqglqva lcsqaklqaq qellqtkleh lgpgepppvl llqddrhsts sseqereggr
      421 tptleilksh isgifrpkfs lppplqlipe vqkplheqlw yhgaipraev aellvhsgdf
      481 lvresqgkqe yvlsvlwdgl prhfiiqsld nlyrlegegf psipllidhl lstqqpltkk
      541 sgvvlhravp kdkwvlnhed lvlgeqigrg nfgevfsgrl radntlvavk scretlppdl
      601 kakflqeari lkqyshpniv rligvctqkq piyivmelvq ggdfltflrt egarlrvktl
      661 lqmvgdaaag meyleskcci hrdlaarncl vteknvlkis dfgmsreead gvyaasgglr
      721 qvpvkwtape alnygrysse sdvwsfgill wetfslgasp ypnlsnqqtr efvekggrlp
      781 cpelcpdavf rlmeqcwaye pgqrpsfsti yqelqsirkr hr
//
LOCUS       XP_047288189             822 aa            linear   PRI 05-AUG-2025
DEFINITION  tyrosine-protein kinase Fes/Fps isoform X1 [Homo sapiens].
ACCESSION   XP_047288189
VERSION     XP_047288189.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432233.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..822
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..822
                     /product="tyrosine-protein kinase Fes/Fps isoform X1"
                     /calculated_mol_wt=93366
     Region          7..239
                     /region_name="F-BAR_Fes"
                     /note="The F-BAR (FES-CIP4 Homology and
                     Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma)
                     tyrosine kinase; cd07685"
                     /db_xref="CDD:153369"
     Site            order(12,15,22,25..26,29,32..33,36..37,40,44,47,51,79,82,
                     169,173,198,206,209,212..213,216,220,223,227,231,234..235,
                     238)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:153369"
     Region          453..537
                     /region_name="SH2_Fps_family"
                     /note="Src homology 2 (SH2) domain found in feline
                     sarcoma, Fujinami poultry sarcoma, and fes-related
                     (Fes/Fps/Fer) proteins; cd10361"
                     /db_xref="CDD:198224"
     Site            order(467,483,503,505)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198224"
     Site            order(504,530)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198224"
     Region          564..815
                     /region_name="PTKc_Fes"
                     /note="Catalytic domain of the Protein Tyrosine Kinase,
                     Fes; cd05084"
                     /db_xref="CDD:270667"
     Site            order(567..569,575,588,590,607,636..639,642..643,683,
                     687..688,690,700..701,704,719..724,726,732,766,770)
                     /site_type="active"
                     /db_xref="CDD:270667"
     Site            order(567..569,575,588,590,607,636..639,642..643,687..688,
                     690,700..701)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270667"
     Site            order(683,687..688,704,719..724,726,732,766,770)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270667"
     Site            700..725
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270667"
     CDS             1..822
                     /gene="FES"
                     /gene_synonym="FPS"
                     /coded_by="XM_047432233.1:141..2609"
                     /db_xref="GeneID:2242"
                     /db_xref="HGNC:HGNC:3657"
                     /db_xref="MIM:190030"
ORIGIN      
        1 mgfsselcsp qghgvlqqmq eaelrllegm rkwmaqrvks dreyagllhh mslqdsggqs
       61 raispdspis qswaeitsqt eglsrllrqh aedlnsgpls klsllirerq qlrktyseqw
      121 qqlqqeltkt hsqdieklks qyralardsa qakrkyqeas kdkdrdkakd kyvrslwklf
      181 ahhnryvlgv raaqlhhqhh hqlllpgllr slqdlheema cilkeilqey leisslvqde
      241 vvaihremaa aaariqpeae yqgflrqygs apdvppcvtf deslleegep lepgelqlne
      301 ltvesvqhtl tsvtdelava temvfrrqem vtqlqqelrn eeenthprer vqllgkrqvl
      361 qealqglqva lcsqaklqaq qellqtkleh lgpgepppvl llqddrhsts sseqereggr
      421 tptleilksh isgifrpkfs lppplqlipe vqkplheqlw yhgaipraev aellvhsgdf
      481 lvresqgkqe yvlsvlwdgl prhfiiqsld nlyrlegegf psipllidhl lstqqpltkk
      541 sgvvlhravp kdkwvlnhed lvlgeqigrg nfgevfsgrl radntlvavk scretlppdl
      601 kakflqeari lkqyshpniv rligvctqkq piyivmelvq ggdfltflrt egarlrvktl
      661 lqmvgdaaag meyleskcci hrdlaarncl vteknvlkis dfgmsreead gvyaasgglr
      721 qvpvkwtape alnygrysse sdvwsfgill wetfslgasp ypnlsnqqtr efvekggrlp
      781 cpelcpdavf rlmeqcwaye pgqrpsfsti yqelqsirkr hr
//
LOCUS       XP_005254937             764 aa            linear   PRI 05-AUG-2025
DEFINITION  tyrosine-protein kinase Fes/Fps isoform X2 [Homo sapiens].
ACCESSION   XP_005254937
VERSION     XP_005254937.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254880.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..764
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..764
                     /product="tyrosine-protein kinase Fes/Fps isoform X2"
                     /calculated_mol_wt=86532
     Region          7..181
                     /region_name="BAR"
                     /note="The Bin/Amphiphysin/Rvs (BAR) domain, a
                     dimerization module that binds membranes and detects
                     membrane curvature; cl12013"
                     /db_xref="CDD:472257"
     Site            order(12,15..16,20,22..23,26..27,29..30,40..41,43..44,
                     47..48,50..51,54,136,139..140,142,148,151..152,154..155,
                     158..159,162..163,165..166,169..170,172..173)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:153369"
     Region          395..479
                     /region_name="SH2_Fps_family"
                     /note="Src homology 2 (SH2) domain found in feline
                     sarcoma, Fujinami poultry sarcoma, and fes-related
                     (Fes/Fps/Fer) proteins; cd10361"
                     /db_xref="CDD:198224"
     Site            order(409,425,445,447)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198224"
     Site            order(446,472)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198224"
     Region          506..757
                     /region_name="PTKc_Fes"
                     /note="Catalytic domain of the Protein Tyrosine Kinase,
                     Fes; cd05084"
                     /db_xref="CDD:270667"
     Site            order(509..511,517,530,532,549,578..581,584..585,625,
                     629..630,632,642..643,646,661..666,668,674,708,712)
                     /site_type="active"
                     /db_xref="CDD:270667"
     Site            order(509..511,517,530,532,549,578..581,584..585,629..630,
                     632,642..643)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270667"
     Site            order(625,629..630,646,661..666,668,674,708,712)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270667"
     Site            642..667
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270667"
     CDS             1..764
                     /gene="FES"
                     /gene_synonym="FPS"
                     /coded_by="XM_005254880.2:51..2345"
                     /db_xref="GeneID:2242"
                     /db_xref="HGNC:HGNC:3657"
                     /db_xref="MIM:190030"
ORIGIN      
        1 mgfsselcsp qghgvlqqmq eaelrllegm rkwmaqrvks dreyagllhh mslqdsggqs
       61 raispdspis qthsqdiekl ksqyralard saqakrkyqe askdkdrdka kdkyvrslwk
      121 lfahhnryvl gvraaqlhhq hhhqlllpgl lrslqdlhee macilkeilq eyleisslvq
      181 devvaihrem aaaaariqpe aeyqgflrqy gsapdvppcv tfdeslleeg eplepgelql
      241 neltvesvqh tltsvtdela vatemvfrrq emvtqlqqel rneeenthpr ervqllgkrq
      301 vlqealqglq valcsqaklq aqqellqtkl ehlgpgeppp vlllqddrhs tssseqereg
      361 grtptleilk shisgifrpk fslppplqli pevqkplheq lwyhgaipra evaellvhsg
      421 dflvresqgk qeyvlsvlwd glprhfiiqs ldnlyrlege gfpsipllid hllstqqplt
      481 kksgvvlhra vpkdkwvlnh edlvlgeqig rgnfgevfsg rlradntlva vkscretlpp
      541 dlkakflqea rilkqyshpn ivrligvctq kqpiyivmel vqggdfltfl rtegarlrvk
      601 tllqmvgdaa agmeyleskc cihrdlaarn clvteknvlk isdfgmsree adgvyaasgg
      661 lrqvpvkwta pealnygrys sesdvwsfgi llwetfslga spypnlsnqq trefvekggr
      721 lpcpelcpda vfrlmeqcwa yepgqrpsfs tiyqelqsir krhr
//
LOCUS       XP_016877499             764 aa            linear   PRI 05-AUG-2025
DEFINITION  tyrosine-protein kinase Fes/Fps isoform X2 [Homo sapiens].
ACCESSION   XP_016877499
VERSION     XP_016877499.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022010.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..764
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..764
                     /product="tyrosine-protein kinase Fes/Fps isoform X2"
                     /calculated_mol_wt=86532
     Region          7..181
                     /region_name="BAR"
                     /note="The Bin/Amphiphysin/Rvs (BAR) domain, a
                     dimerization module that binds membranes and detects
                     membrane curvature; cl12013"
                     /db_xref="CDD:472257"
     Site            order(12,15..16,20,22..23,26..27,29..30,40..41,43..44,
                     47..48,50..51,54,136,139..140,142,148,151..152,154..155,
                     158..159,162..163,165..166,169..170,172..173)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:153369"
     Region          395..479
                     /region_name="SH2_Fps_family"
                     /note="Src homology 2 (SH2) domain found in feline
                     sarcoma, Fujinami poultry sarcoma, and fes-related
                     (Fes/Fps/Fer) proteins; cd10361"
                     /db_xref="CDD:198224"
     Site            order(409,425,445,447)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198224"
     Site            order(446,472)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198224"
     Region          506..757
                     /region_name="PTKc_Fes"
                     /note="Catalytic domain of the Protein Tyrosine Kinase,
                     Fes; cd05084"
                     /db_xref="CDD:270667"
     Site            order(509..511,517,530,532,549,578..581,584..585,625,
                     629..630,632,642..643,646,661..666,668,674,708,712)
                     /site_type="active"
                     /db_xref="CDD:270667"
     Site            order(509..511,517,530,532,549,578..581,584..585,629..630,
                     632,642..643)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270667"
     Site            order(625,629..630,646,661..666,668,674,708,712)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270667"
     Site            642..667
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270667"
     CDS             1..764
                     /gene="FES"
                     /gene_synonym="FPS"
                     /coded_by="XM_017022010.2:146..2440"
                     /db_xref="GeneID:2242"
                     /db_xref="HGNC:HGNC:3657"
                     /db_xref="MIM:190030"
ORIGIN      
        1 mgfsselcsp qghgvlqqmq eaelrllegm rkwmaqrvks dreyagllhh mslqdsggqs
       61 raispdspis qthsqdiekl ksqyralard saqakrkyqe askdkdrdka kdkyvrslwk
      121 lfahhnryvl gvraaqlhhq hhhqlllpgl lrslqdlhee macilkeilq eyleisslvq
      181 devvaihrem aaaaariqpe aeyqgflrqy gsapdvppcv tfdeslleeg eplepgelql
      241 neltvesvqh tltsvtdela vatemvfrrq emvtqlqqel rneeenthpr ervqllgkrq
      301 vlqealqglq valcsqaklq aqqellqtkl ehlgpgeppp vlllqddrhs tssseqereg
      361 grtptleilk shisgifrpk fslppplqli pevqkplheq lwyhgaipra evaellvhsg
      421 dflvresqgk qeyvlsvlwd glprhfiiqs ldnlyrlege gfpsipllid hllstqqplt
      481 kksgvvlhra vpkdkwvlnh edlvlgeqig rgnfgevfsg rlradntlva vkscretlpp
      541 dlkakflqea rilkqyshpn ivrligvctq kqpiyivmel vqggdfltfl rtegarlrvk
      601 tllqmvgdaa agmeyleskc cihrdlaarn clvteknvlk isdfgmsree adgvyaasgg
      661 lrqvpvkwta pealnygrys sesdvwsfgi llwetfslga spypnlsnqq trefvekggr
      721 lpcpelcpda vfrlmeqcwa yepgqrpsfs tiyqelqsir krhr
//
LOCUS       XP_047288190             764 aa            linear   PRI 05-AUG-2025
DEFINITION  tyrosine-protein kinase Fes/Fps isoform X2 [Homo sapiens].
ACCESSION   XP_047288190
VERSION     XP_047288190.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432234.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..764
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..764
                     /product="tyrosine-protein kinase Fes/Fps isoform X2"
                     /calculated_mol_wt=86532
     Region          7..181
                     /region_name="BAR"
                     /note="The Bin/Amphiphysin/Rvs (BAR) domain, a
                     dimerization module that binds membranes and detects
                     membrane curvature; cl12013"
                     /db_xref="CDD:472257"
     Site            order(12,15..16,20,22..23,26..27,29..30,40..41,43..44,
                     47..48,50..51,54,136,139..140,142,148,151..152,154..155,
                     158..159,162..163,165..166,169..170,172..173)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:153369"
     Region          395..479
                     /region_name="SH2_Fps_family"
                     /note="Src homology 2 (SH2) domain found in feline
                     sarcoma, Fujinami poultry sarcoma, and fes-related
                     (Fes/Fps/Fer) proteins; cd10361"
                     /db_xref="CDD:198224"
     Site            order(409,425,445,447)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198224"
     Site            order(446,472)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198224"
     Region          506..757
                     /region_name="PTKc_Fes"
                     /note="Catalytic domain of the Protein Tyrosine Kinase,
                     Fes; cd05084"
                     /db_xref="CDD:270667"
     Site            order(509..511,517,530,532,549,578..581,584..585,625,
                     629..630,632,642..643,646,661..666,668,674,708,712)
                     /site_type="active"
                     /db_xref="CDD:270667"
     Site            order(509..511,517,530,532,549,578..581,584..585,629..630,
                     632,642..643)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270667"
     Site            order(625,629..630,646,661..666,668,674,708,712)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270667"
     Site            642..667
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270667"
     CDS             1..764
                     /gene="FES"
                     /gene_synonym="FPS"
                     /coded_by="XM_047432234.1:141..2435"
                     /db_xref="GeneID:2242"
                     /db_xref="HGNC:HGNC:3657"
                     /db_xref="MIM:190030"
ORIGIN      
        1 mgfsselcsp qghgvlqqmq eaelrllegm rkwmaqrvks dreyagllhh mslqdsggqs
       61 raispdspis qthsqdiekl ksqyralard saqakrkyqe askdkdrdka kdkyvrslwk
      121 lfahhnryvl gvraaqlhhq hhhqlllpgl lrslqdlhee macilkeilq eyleisslvq
      181 devvaihrem aaaaariqpe aeyqgflrqy gsapdvppcv tfdeslleeg eplepgelql
      241 neltvesvqh tltsvtdela vatemvfrrq emvtqlqqel rneeenthpr ervqllgkrq
      301 vlqealqglq valcsqaklq aqqellqtkl ehlgpgeppp vlllqddrhs tssseqereg
      361 grtptleilk shisgifrpk fslppplqli pevqkplheq lwyhgaipra evaellvhsg
      421 dflvresqgk qeyvlsvlwd glprhfiiqs ldnlyrlege gfpsipllid hllstqqplt
      481 kksgvvlhra vpkdkwvlnh edlvlgeqig rgnfgevfsg rlradntlva vkscretlpp
      541 dlkakflqea rilkqyshpn ivrligvctq kqpiyivmel vqggdfltfl rtegarlrvk
      601 tllqmvgdaa agmeyleskc cihrdlaarn clvteknvlk isdfgmsree adgvyaasgg
      661 lrqvpvkwta pealnygrys sesdvwsfgi llwetfslga spypnlsnqq trefvekggr
      721 lpcpelcpda vfrlmeqcwa yepgqrpsfs tiyqelqsir krhr
//
LOCUS       XP_005254939             752 aa            linear   PRI 05-AUG-2025
DEFINITION  tyrosine-protein kinase Fes/Fps isoform X3 [Homo sapiens].
ACCESSION   XP_005254939
VERSION     XP_005254939.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254882.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..752
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..752
                     /product="tyrosine-protein kinase Fes/Fps isoform X3"
                     /calculated_mol_wt=85336
     Region          7..239
                     /region_name="BAR"
                     /note="The Bin/Amphiphysin/Rvs (BAR) domain, a
                     dimerization module that binds membranes and detects
                     membrane curvature; cl12013"
                     /db_xref="CDD:472257"
     Site            order(12,15..16,20,22..23,26..27,29..30,40..41,43..44,
                     47..48,50..51,54,82,85..86,194,197..198,200,206,209..210,
                     212..213,216..217,220..221,223..224,227..228,230..231)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:153369"
     Region          494..745
                     /region_name="PTKc_Fes"
                     /note="Catalytic domain of the Protein Tyrosine Kinase,
                     Fes; cd05084"
                     /db_xref="CDD:270667"
     Site            order(497..499,505,518,520,537,566..569,572..573,613,
                     617..618,620,630..631,634,649..654,656,662,696,700)
                     /site_type="active"
                     /db_xref="CDD:270667"
     Site            order(497..499,505,518,520,537,566..569,572..573,617..618,
                     620,630..631)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270667"
     Site            order(613,617..618,634,649..654,656,662,696,700)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270667"
     Site            630..655
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270667"
     CDS             1..752
                     /gene="FES"
                     /gene_synonym="FPS"
                     /coded_by="XM_005254882.3:51..2309"
                     /db_xref="GeneID:2242"
                     /db_xref="HGNC:HGNC:3657"
                     /db_xref="MIM:190030"
ORIGIN      
        1 mgfsselcsp qghgvlqqmq eaelrllegm rkwmaqrvks dreyagllhh mslqdsggqs
       61 raispdspis qswaeitsqt eglsrllrqh aedlnsgpls klsllirerq qlrktyseqw
      121 qqlqqeltkt hsqdieklks qyralardsa qakrkyqeas kdkdrdkakd kyvrslwklf
      181 ahhnryvlgv raaqlhhqhh hqlllpgllr slqdlheema cilkeilqey leisslvqde
      241 vvaihremaa aaariqpeae yqgflrqygs apdvppcvtf deslleegep lepgelqlne
      301 ltvesvqhtl tsvtdelava temvfrrqem vtqlqqelrn eeenthprer vqllgkrqvl
      361 qealqglqva lcsqaklqaq qellqtkleh lgpgepppvl llqddrhsts sseqereggr
      421 tptleilksh isgifrpkfs nlyrlegegf psipllidhl lstqqpltkk sgvvlhravp
      481 kdkwvlnhed lvlgeqigrg nfgevfsgrl radntlvavk scretlppdl kakflqeari
      541 lkqyshpniv rligvctqkq piyivmelvq ggdfltflrt egarlrvktl lqmvgdaaag
      601 meyleskcci hrdlaarncl vteknvlkis dfgmsreead gvyaasgglr qvpvkwtape
      661 alnygrysse sdvwsfgill wetfslgasp ypnlsnqqtr efvekggrlp cpelcpdavf
      721 rlmeqcwaye pgqrpsfsti yqelqsirkr hr
//
LOCUS       XP_047288191             752 aa            linear   PRI 05-AUG-2025
DEFINITION  tyrosine-protein kinase Fes/Fps isoform X3 [Homo sapiens].
ACCESSION   XP_047288191
VERSION     XP_047288191.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432235.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..752
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..752
                     /product="tyrosine-protein kinase Fes/Fps isoform X3"
                     /calculated_mol_wt=85336
     Region          7..239
                     /region_name="BAR"
                     /note="The Bin/Amphiphysin/Rvs (BAR) domain, a
                     dimerization module that binds membranes and detects
                     membrane curvature; cl12013"
                     /db_xref="CDD:472257"
     Site            order(12,15..16,20,22..23,26..27,29..30,40..41,43..44,
                     47..48,50..51,54,82,85..86,194,197..198,200,206,209..210,
                     212..213,216..217,220..221,223..224,227..228,230..231)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:153369"
     Region          494..745
                     /region_name="PTKc_Fes"
                     /note="Catalytic domain of the Protein Tyrosine Kinase,
                     Fes; cd05084"
                     /db_xref="CDD:270667"
     Site            order(497..499,505,518,520,537,566..569,572..573,613,
                     617..618,620,630..631,634,649..654,656,662,696,700)
                     /site_type="active"
                     /db_xref="CDD:270667"
     Site            order(497..499,505,518,520,537,566..569,572..573,617..618,
                     620,630..631)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270667"
     Site            order(613,617..618,634,649..654,656,662,696,700)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270667"
     Site            630..655
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270667"
     CDS             1..752
                     /gene="FES"
                     /gene_synonym="FPS"
                     /coded_by="XM_047432235.1:146..2404"
                     /db_xref="GeneID:2242"
                     /db_xref="HGNC:HGNC:3657"
                     /db_xref="MIM:190030"
ORIGIN      
        1 mgfsselcsp qghgvlqqmq eaelrllegm rkwmaqrvks dreyagllhh mslqdsggqs
       61 raispdspis qswaeitsqt eglsrllrqh aedlnsgpls klsllirerq qlrktyseqw
      121 qqlqqeltkt hsqdieklks qyralardsa qakrkyqeas kdkdrdkakd kyvrslwklf
      181 ahhnryvlgv raaqlhhqhh hqlllpgllr slqdlheema cilkeilqey leisslvqde
      241 vvaihremaa aaariqpeae yqgflrqygs apdvppcvtf deslleegep lepgelqlne
      301 ltvesvqhtl tsvtdelava temvfrrqem vtqlqqelrn eeenthprer vqllgkrqvl
      361 qealqglqva lcsqaklqaq qellqtkleh lgpgepppvl llqddrhsts sseqereggr
      421 tptleilksh isgifrpkfs nlyrlegegf psipllidhl lstqqpltkk sgvvlhravp
      481 kdkwvlnhed lvlgeqigrg nfgevfsgrl radntlvavk scretlppdl kakflqeari
      541 lkqyshpniv rligvctqkq piyivmelvq ggdfltflrt egarlrvktl lqmvgdaaag
      601 meyleskcci hrdlaarncl vteknvlkis dfgmsreead gvyaasgglr qvpvkwtape
      661 alnygrysse sdvwsfgill wetfslgasp ypnlsnqqtr efvekggrlp cpelcpdavf
      721 rlmeqcwaye pgqrpsfsti yqelqsirkr hr
//
LOCUS       XP_047288192             542 aa            linear   PRI 05-AUG-2025
DEFINITION  tyrosine-protein kinase Fes/Fps isoform X5 [Homo sapiens].
ACCESSION   XP_047288192
VERSION     XP_047288192.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432236.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..542
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..542
                     /product="tyrosine-protein kinase Fes/Fps isoform X5"
                     /calculated_mol_wt=61132
     Region          7..239
                     /region_name="BAR"
                     /note="The Bin/Amphiphysin/Rvs (BAR) domain, a
                     dimerization module that binds membranes and detects
                     membrane curvature; cl12013"
                     /db_xref="CDD:472257"
     Site            order(12,15..16,20,22..23,26..27,29..30,40..41,43..44,
                     47..48,50..51,54,82,85..86,194,197..198,200,206,209..210,
                     212..213,216..217,220..221,223..224,227..228,230..231)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:153369"
     CDS             1..542
                     /gene="FES"
                     /gene_synonym="FPS"
                     /coded_by="XM_047432236.1:46..1674"
                     /db_xref="GeneID:2242"
                     /db_xref="HGNC:HGNC:3657"
                     /db_xref="MIM:190030"
ORIGIN      
        1 mgfsselcsp qghgvlqqmq eaelrllegm rkwmaqrvks dreyagllhh mslqdsggqs
       61 raispdspis qswaeitsqt eglsrllrqh aedlnsgpls klsllirerq qlrktyseqw
      121 qqlqqeltkt hsqdieklks qyralardsa qakrkyqeas kdkdrdkakd kyvrslwklf
      181 ahhnryvlgv raaqlhhqhh hqlllpgllr slqdlheema cilkeilqey leisslvqde
      241 vvaihremaa aaariqpeae yqgflrqygs apdvppcvtf deslleegep lepgelqlne
      301 ltvesvqhtl tsvtdelava temvfrrqem vtqlqqelrn eeenthprer vqllgkrqvl
      361 qealqglqva lcsqaklqaq qellqtkleh lgpgepppvl llqddrhsts sspghpltsv
      421 pglrsrserg eghprwrslr atsqessaps srslhrcssf rrcrspcmss cgttgpsrgq
      481 rwlscwctlg tswcgraras rstccrccgm vcpgtssssp witctdwkgk aflaflcsst
      541 ty
//
LOCUS       XP_047288193             694 aa            linear   PRI 05-AUG-2025
DEFINITION  tyrosine-protein kinase Fes/Fps isoform X4 [Homo sapiens].
ACCESSION   XP_047288193
VERSION     XP_047288193.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432237.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..694
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..694
                     /product="tyrosine-protein kinase Fes/Fps isoform X4"
                     /calculated_mol_wt=78502
     Region          7..181
                     /region_name="BAR"
                     /note="The Bin/Amphiphysin/Rvs (BAR) domain, a
                     dimerization module that binds membranes and detects
                     membrane curvature; cl12013"
                     /db_xref="CDD:472257"
     Site            order(12,15..16,20,22..23,26..27,29..30,40..41,43..44,
                     47..48,50..51,54,136,139..140,142,148,151..152,154..155,
                     158..159,162..163,165..166,169..170,172..173)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:153271"
     Region          436..687
                     /region_name="PTKc_Fes"
                     /note="Catalytic domain of the Protein Tyrosine Kinase,
                     Fes; cd05084"
                     /db_xref="CDD:270667"
     Site            order(439..441,447,460,462,479,508..511,514..515,555,
                     559..560,562,572..573,576,591..596,598,604,638,642)
                     /site_type="active"
                     /db_xref="CDD:270667"
     Site            order(439..441,447,460,462,479,508..511,514..515,559..560,
                     562,572..573)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270667"
     Site            order(555,559..560,576,591..596,598,604,638,642)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270667"
     Site            572..597
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270667"
     CDS             1..694
                     /gene="FES"
                     /gene_synonym="FPS"
                     /coded_by="XM_047432237.1:146..2230"
                     /db_xref="GeneID:2242"
                     /db_xref="HGNC:HGNC:3657"
                     /db_xref="MIM:190030"
ORIGIN      
        1 mgfsselcsp qghgvlqqmq eaelrllegm rkwmaqrvks dreyagllhh mslqdsggqs
       61 raispdspis qthsqdiekl ksqyralard saqakrkyqe askdkdrdka kdkyvrslwk
      121 lfahhnryvl gvraaqlhhq hhhqlllpgl lrslqdlhee macilkeilq eyleisslvq
      181 devvaihrem aaaaariqpe aeyqgflrqy gsapdvppcv tfdeslleeg eplepgelql
      241 neltvesvqh tltsvtdela vatemvfrrq emvtqlqqel rneeenthpr ervqllgkrq
      301 vlqealqglq valcsqaklq aqqellqtkl ehlgpgeppp vlllqddrhs tssseqereg
      361 grtptleilk shisgifrpk fsnlyrlege gfpsipllid hllstqqplt kksgvvlhra
      421 vpkdkwvlnh edlvlgeqig rgnfgevfsg rlradntlva vkscretlpp dlkakflqea
      481 rilkqyshpn ivrligvctq kqpiyivmel vqggdfltfl rtegarlrvk tllqmvgdaa
      541 agmeyleskc cihrdlaarn clvteknvlk isdfgmsree adgvyaasgg lrqvpvkwta
      601 pealnygrys sesdvwsfgi llwetfslga spypnlsnqq trefvekggr lpcpelcpda
      661 vfrlmeqcwa yepgqrpsfs tiyqelqsir krhr
//
LOCUS       XP_047288194             472 aa            linear   PRI 05-AUG-2025
DEFINITION  tyrosine-protein kinase Fes/Fps isoform X6 [Homo sapiens].
ACCESSION   XP_047288194
VERSION     XP_047288194.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432238.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..472
                     /product="tyrosine-protein kinase Fes/Fps isoform X6"
                     /calculated_mol_wt=53519
     Region          7..239
                     /region_name="BAR"
                     /note="The Bin/Amphiphysin/Rvs (BAR) domain, a
                     dimerization module that binds membranes and detects
                     membrane curvature; cl12013"
                     /db_xref="CDD:472257"
     Site            order(12,15..16,20,22..23,26..27,29..30,40..41,43..44,
                     47..48,50..51,54,82,85..86,194,197..198,200,206,209..210,
                     212..213,216..217,220..221,223..224,227..228,230..231)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:153369"
     CDS             1..472
                     /gene="FES"
                     /gene_synonym="FPS"
                     /coded_by="XM_047432238.1:46..1464"
                     /db_xref="GeneID:2242"
                     /db_xref="HGNC:HGNC:3657"
                     /db_xref="MIM:190030"
ORIGIN      
        1 mgfsselcsp qghgvlqqmq eaelrllegm rkwmaqrvks dreyagllhh mslqdsggqs
       61 raispdspis qswaeitsqt eglsrllrqh aedlnsgpls klsllirerq qlrktyseqw
      121 qqlqqeltkt hsqdieklks qyralardsa qakrkyqeas kdkdrdkakd kyvrslwklf
      181 ahhnryvlgv raaqlhhqhh hqlllpgllr slqdlheema cilkeilqey leisslvqde
      241 vvaihremaa aaariqpeae yqgflrqygs apdvppcvtf deslleegep lepgelqlne
      301 ltvesvqhtl tsvtdelava temvfrrqem vtqlqqelrn eeenthprer vqllgkrqvl
      361 qealqglqva lcsqaklqaq qellqtkleh lgpgepppvl llqddrhsts sspghpltsv
      421 pglrsrserg eghprwrslr atsqessaps srtctdwkgk aflaflcsst ty
//
LOCUS       XP_047288195             542 aa            linear   PRI 05-AUG-2025
DEFINITION  tyrosine-protein kinase Fes/Fps isoform X5 [Homo sapiens].
ACCESSION   XP_047288195
VERSION     XP_047288195.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432239.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..542
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..542
                     /product="tyrosine-protein kinase Fes/Fps isoform X5"
                     /calculated_mol_wt=61132
     Region          7..239
                     /region_name="BAR"
                     /note="The Bin/Amphiphysin/Rvs (BAR) domain, a
                     dimerization module that binds membranes and detects
                     membrane curvature; cl12013"
                     /db_xref="CDD:472257"
     Site            order(12,15..16,20,22..23,26..27,29..30,40..41,43..44,
                     47..48,50..51,54,82,85..86,194,197..198,200,206,209..210,
                     212..213,216..217,220..221,223..224,227..228,230..231)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:153369"
     CDS             1..542
                     /gene="FES"
                     /gene_synonym="FPS"
                     /coded_by="XM_047432239.1:51..1679"
                     /db_xref="GeneID:2242"
                     /db_xref="HGNC:HGNC:3657"
                     /db_xref="MIM:190030"
ORIGIN      
        1 mgfsselcsp qghgvlqqmq eaelrllegm rkwmaqrvks dreyagllhh mslqdsggqs
       61 raispdspis qswaeitsqt eglsrllrqh aedlnsgpls klsllirerq qlrktyseqw
      121 qqlqqeltkt hsqdieklks qyralardsa qakrkyqeas kdkdrdkakd kyvrslwklf
      181 ahhnryvlgv raaqlhhqhh hqlllpgllr slqdlheema cilkeilqey leisslvqde
      241 vvaihremaa aaariqpeae yqgflrqygs apdvppcvtf deslleegep lepgelqlne
      301 ltvesvqhtl tsvtdelava temvfrrqem vtqlqqelrn eeenthprer vqllgkrqvl
      361 qealqglqva lcsqaklqaq qellqtkleh lgpgepppvl llqddrhsts sspghpltsv
      421 pglrsrserg eghprwrslr atsqessaps srslhrcssf rrcrspcmss cgttgpsrgq
      481 rwlscwctlg tswcgraras rstccrccgm vcpgtssssp witctdwkgk aflaflcsst
      541 ty
//
LOCUS       XP_011519665            1119 aa            linear   PRI 05-AUG-2025
DEFINITION  integrin alpha-11 isoform X1 [Homo sapiens].
ACCESSION   XP_011519665
VERSION     XP_011519665.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521363.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1119
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1119
                     /product="integrin alpha-11 isoform X1"
                     /calculated_mol_wt=125655
     Region          39..>78
                     /region_name="Int_alpha"
                     /note="Integrin alpha (beta-propellor repeats);
                     smart00191"
                     /db_xref="CDD:214549"
     Region          94..272
                     /region_name="vWA_integrins_alpha_subunit"
                     /note="Integrins are a class of adhesion receptors that
                     link the extracellular matrix to the cytoskeleton and
                     cooperate with growth factor receptors to promote celll
                     survival, cell cycle progression and cell migration.
                     Integrins consist of an alpha and a beta...; cd01469"
                     /db_xref="CDD:238746"
     Site            order(94,96,115,196,198,226,261)
                     /site_type="active"
                     /note="integrin inhibitor binding pocket [active]"
                     /db_xref="CDD:238746"
     Site            order(101,103,105,171,202)
                     /site_type="other"
                     /note="metal ion-dependent adhesion site (MIDAS)"
                     /db_xref="CDD:238746"
     Site            order(103..105,107,171)
                     /site_type="active"
                     /note="integrin-collagen binding site [active]"
                     /db_xref="CDD:238746"
     Region          407..>449
                     /region_name="Int_alpha"
                     /note="Integrin alpha (beta-propellor repeats);
                     smart00191"
                     /db_xref="CDD:214549"
     Region          469..523
                     /region_name="Int_alpha"
                     /note="Integrin alpha (beta-propellor repeats);
                     smart00191"
                     /db_xref="CDD:214549"
     Region          567..966
                     /region_name="Integrin_alpha2"
                     /note="Integrin alpha; pfam08441"
                     /db_xref="CDD:462478"
     CDS             1..1119
                     /gene="ITGA11"
                     /gene_synonym="HsT18964"
                     /coded_by="XM_011521363.3:98..3457"
                     /db_xref="GeneID:22801"
                     /db_xref="HGNC:HGNC:6136"
                     /db_xref="MIM:604789"
ORIGIN      
        1 mdlprglvva walslwpgft dtfnmdtrkp rvipgsrtaf fgytvqqhdi sgnkwlvvga
       61 pletngyqkt gdvykcpvih gnctklnlgc qtymdivivl dgsnsiypwv evqhflinil
      121 kkfyigpgqi qvgvvqyged vvhefhlndy rsvkdvveaa shieqrggte trtafgiefa
      181 rseafqkggr kgakkvmivi tdgeshdspd lekviqqser dnvtryavav lgyynrrgin
      241 petflneiky iasdpddkhf fnvtdeaalk divdalgdri fslegtnkne tsfglemsqt
      301 gfsshvvedg vllgavgayd wngavlkets agkviplres ylkefpeelk nhgaylgytv
      361 tsvvssrqgr vyvagaprfn htgkvilftm hnnrsltihq amrgqqigsy fgseitsvdi
      421 dgdgvtdvll vgapmyfneg rergkvyvye lrqnlfvyng tlkdshsyqn arfgssiasv
      481 rdlnqdsynd vvvgapledn hagaiyifhg frgsilktpk qritaselat glqyfgcsih
      541 gqldlnedgl idlavgalgn avilwsrpvv qinaslhfep skinifhrdc krsgrdatcl
      601 aaflcftpif laphfqtttv girynatmde rrytprahld eggdrftnra vllssgqelc
      661 erinfhvldt adyvkpvtfs veysledpdh gpmlddgwpt tlrvsvpfwn gcnedehcvp
      721 dlvldarsdl ptameycqrv lrkpaqdcsa ytlsfdttvf iiestrqrva veatlenrge
      781 naystvlnis qsanlqfasl iqkedsdgsi ecvneerrlq kqvcnvsypf frakakvafr
      841 ldfefsksif lhhleielaa gsdsnerdst kednvaplrf hlkyeadvlf trssslshye
      901 vkpnsslery dgigppfsci friqnlglfp ihgmmmkiti piatrsgnrl lklrdfltde
      961 antscniwgn steyrptpve edlrrapqln hsnsdvvsin cnirlvpnqe infhllgnlw
     1021 lrslkalkyk smkimvnaal qrqfhspfif reedpsrqiv feiskqedwq vpiwiivgst
     1081 lggllllall vlalwklgff rsarrrrepg ldptpkvle
//
LOCUS       XP_005254285            1086 aa            linear   PRI 05-AUG-2025
DEFINITION  integrin alpha-11 isoform X2 [Homo sapiens].
ACCESSION   XP_005254285
VERSION     XP_005254285.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254228.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1086
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1086
                     /product="integrin alpha-11 isoform X2"
                     /calculated_mol_wt=121990
     Region          61..239
                     /region_name="vWA_integrins_alpha_subunit"
                     /note="Integrins are a class of adhesion receptors that
                     link the extracellular matrix to the cytoskeleton and
                     cooperate with growth factor receptors to promote celll
                     survival, cell cycle progression and cell migration.
                     Integrins consist of an alpha and a beta...; cd01469"
                     /db_xref="CDD:238746"
     Site            order(61,63,82,163,165,193,228)
                     /site_type="active"
                     /note="integrin inhibitor binding pocket [active]"
                     /db_xref="CDD:238746"
     Site            order(68,70,72,138,169)
                     /site_type="other"
                     /note="metal ion-dependent adhesion site (MIDAS)"
                     /db_xref="CDD:238746"
     Site            order(70..72,74,138)
                     /site_type="active"
                     /note="integrin-collagen binding site [active]"
                     /db_xref="CDD:238746"
     Region          374..>416
                     /region_name="Int_alpha"
                     /note="Integrin alpha (beta-propellor repeats);
                     smart00191"
                     /db_xref="CDD:214549"
     Region          436..490
                     /region_name="Int_alpha"
                     /note="Integrin alpha (beta-propellor repeats);
                     smart00191"
                     /db_xref="CDD:214549"
     Region          500..>524
                     /region_name="Int_alpha"
                     /note="Integrin alpha (beta-propellor repeats);
                     smart00191"
                     /db_xref="CDD:214549"
     Region          534..933
                     /region_name="Integrin_alpha2"
                     /note="Integrin alpha; pfam08441"
                     /db_xref="CDD:462478"
     CDS             1..1086
                     /gene="ITGA11"
                     /gene_synonym="HsT18964"
                     /coded_by="XM_005254228.4:4074..7334"
                     /db_xref="GeneID:22801"
                     /db_xref="HGNC:HGNC:6136"
                     /db_xref="MIM:604789"
ORIGIN      
        1 mrlglslatn pkdnsflacs plwshecgss yyttgmcsrv nsnfrfsktv apalqrcqty
       61 mdivivldgs nsiypwvevq hflinilkkf yigpgqiqvg vvqygedvvh efhlndyrsv
      121 kdvveaashi eqrggtetrt afgiefarse afqkggrkga kkvmivitdg eshdspdlek
      181 viqqserdnv tryavavlgy ynrrginpet flneikyias dpddkhffnv tdeaalkdiv
      241 dalgdrifsl egtnknetsf glemsqtgfs shvvedgvll gavgaydwng avlketsagk
      301 viplresylk efpeelknhg aylgytvtsv vssrqgrvyv agaprfnhtg kvilftmhnn
      361 rsltihqamr gqqigsyfgs eitsvdidgd gvtdvllvga pmyfnegrer gkvyvyelrq
      421 nlfvyngtlk dshsyqnarf gssiasvrdl nqdsyndvvv gaplednhag aiyifhgfrg
      481 silktpkqri taselatglq yfgcsihgql dlnedglidl avgalgnavi lwsrpvvqin
      541 aslhfepski nifhrdckrs grdatclaaf lcftpiflap hfqtttvgir ynatmderry
      601 tprahldegg drftnravll ssgqelceri nfhvldtady vkpvtfsvey sledpdhgpm
      661 lddgwpttlr vsvpfwngcn edehcvpdlv ldarsdlpta meycqrvlrk paqdcsaytl
      721 sfdttvfiie strqrvavea tlenrgenay stvlnisqsa nlqfasliqk edsdgsiecv
      781 neerrlqkqv cnvsypffra kakvafrldf efsksiflhh leielaagsd snerdstked
      841 nvaplrfhlk yeadvlftrs sslshyevkp nsslerydgi gppfscifri qnlglfpihg
      901 mmmkitipia trsgnrllkl rdfltdeant scniwgnste yrptpveedl rrapqlnhsn
      961 sdvvsincni rlvpnqeinf hllgnlwlrs lkalkyksmk imvnaalqrq fhspfifree
     1021 dpsrqivfei skqedwqvpi wiivgstlgg llllallvla lwklgffrsa rrrrepgldp
     1081 tpkvle
//
LOCUS       XP_011519666             830 aa            linear   PRI 05-AUG-2025
DEFINITION  chondroitin sulfate synthase 1 isoform X1 [Homo sapiens].
ACCESSION   XP_011519666
VERSION     XP_011519666.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521364.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..830
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..830
                     /product="chondroitin sulfate synthase 1 isoform X1"
                     /calculated_mol_wt=94697
     Region          87..>265
                     /region_name="Galactosyl_T"
                     /note="Galactosyltransferase; cl21608"
                     /db_xref="CDD:473923"
     Region          238..805
                     /region_name="CHGN"
                     /note="Chondroitin N-acetylgalactosaminyltransferase;
                     pfam05679"
                     /db_xref="CDD:461712"
     CDS             1..830
                     /gene="CHSY1"
                     /gene_synonym="CHSY; ChSy-1; CSS1; TPBS"
                     /coded_by="XM_011521364.3:593..3085"
                     /db_xref="GeneID:22856"
                     /db_xref="HGNC:HGNC:17198"
                     /db_xref="MIM:608183"
ORIGIN      
        1 maargrrawl svllglvlgf vlasrlvlpr aselkragpr rraspegcrs gqaaasqagg
       61 argdargaql wppgsdpdgg prdrnflfvg vmtaqkylqt ravaayrtws ktipgkvqff
      121 ssegsdtsvp ipvvplrgvd dsyppqkksf mmlkymhdhy ldkyewfmra dddvyikgdr
      181 lenflrslns seplflgqtg lgtteemgkl alepgenfcm ggpgvimsre vlrrmvphig
      241 kclremytth edvevgrcvr rfagvqcvws yeaspvaclc qclrhslflm iltvlrsasq
      301 mqqlfyenye qnkkgyirdl hnskihqait lhpnknppyq yrlhsymlsr kiselrhrti
      361 qlhreivlms kysnteihke dlqlgippsf mrfqprqree ilewefltgk ylysavdgqp
      421 prrgmdsaqr ealddivmqv meminanakt rgriidfkei qygyrrvnpm ygaeyildll
      481 llykkhkgkk mtvpvrrhay lqqtfskiqf veheeldaqe lakrinqesg slsflsnslk
      541 klvpfqlpgs ksehkepkdk kiniliplsg rfdmfvrfmg nfektclipn qnvklvvllf
      601 nsdsnpdkak qvelmrdyri kypkadmqil pvsgefsral alevgssqfn nesllffcdv
      661 dlvftteflq rcrantvlgq qiyfpiifsq ydpkivysgk vpsdnhfaft qktgfwrnyg
      721 fgitciykgd lvrvggfdvs iqgwgledvd lfnkvvqagl ktfrsqevgv vhvhhpvfcd
      781 pnldpkqykm clgskastyg stqqlaemwl ekndpsysks snnngsvrta
//
LOCUS       XP_024305641             595 aa            linear   PRI 05-AUG-2025
DEFINITION  chondroitin sulfate synthase 1 isoform X2 [Homo sapiens].
ACCESSION   XP_024305641
VERSION     XP_024305641.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449873.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..595
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..595
                     /product="chondroitin sulfate synthase 1 isoform X2"
                     /calculated_mol_wt=68653
     Region          66..570
                     /region_name="CHGN"
                     /note="Chondroitin N-acetylgalactosaminyltransferase;
                     pfam05679"
                     /db_xref="CDD:461712"
     CDS             1..595
                     /gene="CHSY1"
                     /gene_synonym="CHSY; ChSy-1; CSS1; TPBS"
                     /coded_by="XM_024449873.1:16..1803"
                     /db_xref="GeneID:22856"
                     /db_xref="HGNC:HGNC:17198"
                     /db_xref="MIM:608183"
ORIGIN      
        1 megapwraft gkgdggcsme gvhreggwrv lhgecsqgrr megapwrlft lraraglevp
       61 wpwslmqqlf yenyeqnkkg yirdlhnski hqaitlhpnk nppyqyrlhs ymlsrkisel
      121 rhrtiqlhre ivlmskysnt eihkedlqlg ippsfmrfqp rqreeilewe fltgkylysa
      181 vdgqpprrgm dsaqrealdd ivmqvmemin anaktrgrii dfkeiqygyr rvnpmygaey
      241 ildllllykk hkgkkmtvpv rrhaylqqtf skiqfvehee ldaqelakri nqesgslsfl
      301 snslkklvpf qlpgsksehk epkdkkinil iplsgrfdmf vrfmgnfekt clipnqnvkl
      361 vvllfnsdsn pdkakqvelm rdyrikypka dmqilpvsge fsralalevg ssqfnnesll
      421 ffcdvdlvft teflqrcran tvlgqqiyfp iifsqydpki vysgkvpsdn hfaftqktgf
      481 wrnygfgitc iykgdlvrvg gfdvsiqgwg ledvdlfnkv vqaglktfrs qevgvvhvhh
      541 pvfcdpnldp kqykmclgsk astygstqql aemwlekndp syskssnnng svrta
//
LOCUS       XP_047288196             530 aa            linear   PRI 05-AUG-2025
DEFINITION  chondroitin sulfate synthase 1 isoform X3 [Homo sapiens].
ACCESSION   XP_047288196
VERSION     XP_047288196.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432240.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..530
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..530
                     /product="chondroitin sulfate synthase 1 isoform X3"
                     /calculated_mol_wt=61403
     Region          1..505
                     /region_name="CHGN"
                     /note="Chondroitin N-acetylgalactosaminyltransferase;
                     pfam05679"
                     /db_xref="CDD:461712"
     CDS             1..530
                     /gene="CHSY1"
                     /gene_synonym="CHSY; ChSy-1; CSS1; TPBS"
                     /coded_by="XM_047432240.1:8632..10224"
                     /db_xref="GeneID:22856"
                     /db_xref="HGNC:HGNC:17198"
                     /db_xref="MIM:608183"
ORIGIN      
        1 mqqlfyenye qnkkgyirdl hnskihqait lhpnknppyq yrlhsymlsr kiselrhrti
       61 qlhreivlms kysnteihke dlqlgippsf mrfqprqree ilewefltgk ylysavdgqp
      121 prrgmdsaqr ealddivmqv meminanakt rgriidfkei qygyrrvnpm ygaeyildll
      181 llykkhkgkk mtvpvrrhay lqqtfskiqf veheeldaqe lakrinqesg slsflsnslk
      241 klvpfqlpgs ksehkepkdk kiniliplsg rfdmfvrfmg nfektclipn qnvklvvllf
      301 nsdsnpdkak qvelmrdyri kypkadmqil pvsgefsral alevgssqfn nesllffcdv
      361 dlvftteflq rcrantvlgq qiyfpiifsq ydpkivysgk vpsdnhfaft qktgfwrnyg
      421 fgitciykgd lvrvggfdvs iqgwgledvd lfnkvvqagl ktfrsqevgv vhvhhpvfcd
      481 pnldpkqykm clgskastyg stqqlaemwl ekndpsysks snnngsvrta
//
LOCUS       XP_016877500             530 aa            linear   PRI 05-AUG-2025
DEFINITION  chondroitin sulfate synthase 1 isoform X3 [Homo sapiens].
ACCESSION   XP_016877500
VERSION     XP_016877500.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022011.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..530
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..530
                     /product="chondroitin sulfate synthase 1 isoform X3"
                     /calculated_mol_wt=61403
     Region          1..505
                     /region_name="CHGN"
                     /note="Chondroitin N-acetylgalactosaminyltransferase;
                     pfam05679"
                     /db_xref="CDD:461712"
     CDS             1..530
                     /gene="CHSY1"
                     /gene_synonym="CHSY; ChSy-1; CSS1; TPBS"
                     /coded_by="XM_017022011.2:11997..13589"
                     /db_xref="GeneID:22856"
                     /db_xref="HGNC:HGNC:17198"
                     /db_xref="MIM:608183"
ORIGIN      
        1 mqqlfyenye qnkkgyirdl hnskihqait lhpnknppyq yrlhsymlsr kiselrhrti
       61 qlhreivlms kysnteihke dlqlgippsf mrfqprqree ilewefltgk ylysavdgqp
      121 prrgmdsaqr ealddivmqv meminanakt rgriidfkei qygyrrvnpm ygaeyildll
      181 llykkhkgkk mtvpvrrhay lqqtfskiqf veheeldaqe lakrinqesg slsflsnslk
      241 klvpfqlpgs ksehkepkdk kiniliplsg rfdmfvrfmg nfektclipn qnvklvvllf
      301 nsdsnpdkak qvelmrdyri kypkadmqil pvsgefsral alevgssqfn nesllffcdv
      361 dlvftteflq rcrantvlgq qiyfpiifsq ydpkivysgk vpsdnhfaft qktgfwrnyg
      421 fgitciykgd lvrvggfdvs iqgwgledvd lfnkvvqagl ktfrsqevgv vhvhhpvfcd
      481 pnldpkqykm clgskastyg stqqlaemwl ekndpsysks snnngsvrta
//
LOCUS       XP_011519668             832 aa            linear   PRI 05-AUG-2025
DEFINITION  bromo adjacent homology domain-containing 1 protein isoform X1
            [Homo sapiens].
ACCESSION   XP_011519668
VERSION     XP_011519668.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521366.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Jun 6, 2016 this sequence version replaced XP_011519668.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..832
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..832
                     /product="bromo adjacent homology domain-containing 1
                     protein isoform X1"
                     /calculated_mol_wt=90053
     Region          <329..597
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          675..785
                     /region_name="BAH_BAHCC1"
                     /note="BAH, or Bromo Adjacent Homology domain, as present
                     in mammalian BAHCC1 and similar proteins. BAHCC1 stands
                     for BAH domain and coiled-coil containing 1. BAH domains
                     are found in a variety of proteins playing roles in
                     transcriptional silencing and the...; cd04714"
                     /db_xref="CDD:240065"
     CDS             1..832
                     /gene="BAHD1"
                     /coded_by="XM_011521366.3:2053..4551"
                     /db_xref="GeneID:22893"
                     /db_xref="HGNC:HGNC:29153"
                     /db_xref="MIM:613880"
ORIGIN      
        1 mgnsqnyfhs ssplcssiqe dlcvfilsvl iplglapats glstlsqgwk ysmthtrrks
       61 lpmlssgltg rreplqmeds nmeqgvegve pgmpespghl tgrrknyplr krplvpekpk
      121 ackvlltrle nvagprsade adelppdlpk ppspapssed pglaqprkrr laslnaealn
      181 nllleredts slagtrrsra gdphrsrdrd ratggwsssk krprlgdlgg gsrdlspepa
      241 pdegprrdgd papkrlasln aaaflklsqe relplrlpra haevdgrste ppapkaprpk
      301 wpkvngknyp kawqgassge aagppgwqgc pdepwpsatp cgpsvqpshq plskalespl
      361 glrphlpllm ggqaalkpep grpgeespap kqelhqpsfp tpqlsplpmp gnpadynglc
      421 vgpeltalgs fylycgqegl qcggyspcpm lpegklspva apheegllla pssvpsgtpf
      481 qhppwgssry cssedtgvng ysicgvlpls vthagttcgg cpykmpfaae gcrslgqlef
      541 plpeaghpas pahpllgcpv psvppaaepv phlqtptsep qtvaracpqs akppsgsksg
      601 lrtgsscrht arskaarrps hpkqprvqrp rprrrrrrrt ngwvpvgaac ekavyvldep
      661 epairksyqa verhgetirv rdtvllksgp rktstpyvak isalwenpes gelmmsllwy
      721 yrpehlqggr spsmheplqn evfasrhqdq nsvacieekc yvltfaeycr fcamakrrge
      781 glpsrktalv ppsadystpp hrtvpedtdp elvflcrhvy dfrhgrilkn pq
//
LOCUS       XP_011519669             831 aa            linear   PRI 05-AUG-2025
DEFINITION  bromo adjacent homology domain-containing 1 protein isoform X2
            [Homo sapiens].
ACCESSION   XP_011519669
VERSION     XP_011519669.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521367.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Jun 6, 2016 this sequence version replaced XP_011519669.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..831
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..831
                     /product="bromo adjacent homology domain-containing 1
                     protein isoform X2"
                     /calculated_mol_wt=89924
     Region          <222..604
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          674..784
                     /region_name="BAH_BAHCC1"
                     /note="BAH, or Bromo Adjacent Homology domain, as present
                     in mammalian BAHCC1 and similar proteins. BAHCC1 stands
                     for BAH domain and coiled-coil containing 1. BAH domains
                     are found in a variety of proteins playing roles in
                     transcriptional silencing and the...; cd04714"
                     /db_xref="CDD:240065"
     CDS             1..831
                     /gene="BAHD1"
                     /coded_by="XM_011521367.4:2054..4549"
                     /db_xref="GeneID:22893"
                     /db_xref="HGNC:HGNC:29153"
                     /db_xref="MIM:613880"
ORIGIN      
        1 mgnsqnyfhs ssplcssiqe dlcvfilsvl iplglapats glstlsqgwk ysmthtrrks
       61 lpmlssgltg rreplqmeds nmeqgvegve pgmpespghl tgrrknyplr krplvpekpk
      121 ackvlltrle nvagprsade adelppdlpk ppspapssed pglaqprkrr laslnaealn
      181 nllleredts slagtrrsra gdphrsrdrd ratggwsssk krprlgdlgg gsrdlspepa
      241 pdegprrdgd papkrlasln aaaflklsqe relplrlpra haevdgrste ppapkaprpk
      301 wpkvngknyp kawqgassge aagppgwqgc pdepwpsatp cgpsvqpshq plskalespl
      361 glrphlpllm ggqaalkpep grpgeespap kqelhqpsfp tpqlsplpmp gnpadynglc
      421 vgpeltalgs fylycgqegl qcggyspcpm lpegklspva apheegllla pssvpsgtpf
      481 qhppwgssry cssedtgvng ysicgvlpls vthagttcgg cpykmpfaag crslgqlefp
      541 lpeaghpasp ahpllgcpvp svppaaepvp hlqtptsepq tvaracpqsa kppsgsksgl
      601 rtgsscrhta rskaarrpsh pkqprvqrpr prrrrrrrtn gwvpvgaace kavyvldepe
      661 pairksyqav erhgetirvr dtvllksgpr ktstpyvaki salwenpesg elmmsllwyy
      721 rpehlqggrs psmheplqne vfasrhqdqn svacieekcy vltfaeycrf camakrrgeg
      781 lpsrktalvp psadystpph rtvpedtdpe lvflcrhvyd frhgrilknp q
//
LOCUS       XP_011519670             829 aa            linear   PRI 05-AUG-2025
DEFINITION  bromo adjacent homology domain-containing 1 protein isoform X3
            [Homo sapiens].
ACCESSION   XP_011519670
VERSION     XP_011519670.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521368.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Jun 6, 2016 this sequence version replaced XP_011519670.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..829
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..829
                     /product="bromo adjacent homology domain-containing 1
                     protein isoform X3"
                     /calculated_mol_wt=89714
     Region          <329..597
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          675..782
                     /region_name="BAH_BAHCC1"
                     /note="BAH, or Bromo Adjacent Homology domain, as present
                     in mammalian BAHCC1 and similar proteins. BAHCC1 stands
                     for BAH domain and coiled-coil containing 1. BAH domains
                     are found in a variety of proteins playing roles in
                     transcriptional silencing and the...; cd04714"
                     /db_xref="CDD:240065"
     CDS             1..829
                     /gene="BAHD1"
                     /coded_by="XM_011521368.3:2053..4542"
                     /db_xref="GeneID:22893"
                     /db_xref="HGNC:HGNC:29153"
                     /db_xref="MIM:613880"
ORIGIN      
        1 mgnsqnyfhs ssplcssiqe dlcvfilsvl iplglapats glstlsqgwk ysmthtrrks
       61 lpmlssgltg rreplqmeds nmeqgvegve pgmpespghl tgrrknyplr krplvpekpk
      121 ackvlltrle nvagprsade adelppdlpk ppspapssed pglaqprkrr laslnaealn
      181 nllleredts slagtrrsra gdphrsrdrd ratggwsssk krprlgdlgg gsrdlspepa
      241 pdegprrdgd papkrlasln aaaflklsqe relplrlpra haevdgrste ppapkaprpk
      301 wpkvngknyp kawqgassge aagppgwqgc pdepwpsatp cgpsvqpshq plskalespl
      361 glrphlpllm ggqaalkpep grpgeespap kqelhqpsfp tpqlsplpmp gnpadynglc
      421 vgpeltalgs fylycgqegl qcggyspcpm lpegklspva apheegllla pssvpsgtpf
      481 qhppwgssry cssedtgvng ysicgvlpls vthagttcgg cpykmpfaae gcrslgqlef
      541 plpeaghpas pahpllgcpv psvppaaepv phlqtptsep qtvaracpqs akppsgsksg
      601 lrtgsscrht arskaarrps hpkqprvqrp rprrrrrrrt ngwvpvgaac ekavyvldep
      661 epairksyqa verhgetirv rdtvllksgp rktstpyvak isalwenpes gelmmsllwy
      721 yrpehlqggr spsmhenevf asrhqdqnsv acieekcyvl tfaeycrfca makrrgeglp
      781 srktalvpps adystpphrt vpedtdpelv flcrhvydfr hgrilknpq
//
LOCUS       XP_047288197             828 aa            linear   PRI 05-AUG-2025
DEFINITION  bromo adjacent homology domain-containing 1 protein isoform X4
            [Homo sapiens].
ACCESSION   XP_047288197
VERSION     XP_047288197.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432241.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..828
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..828
                     /product="bromo adjacent homology domain-containing 1
                     protein isoform X4"
                     /calculated_mol_wt=89585
     Region          <222..604
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          674..781
                     /region_name="BAH_BAHCC1"
                     /note="BAH, or Bromo Adjacent Homology domain, as present
                     in mammalian BAHCC1 and similar proteins. BAHCC1 stands
                     for BAH domain and coiled-coil containing 1. BAH domains
                     are found in a variety of proteins playing roles in
                     transcriptional silencing and the...; cd04714"
                     /db_xref="CDD:240065"
     CDS             1..828
                     /gene="BAHD1"
                     /coded_by="XM_047432241.1:2054..4540"
                     /db_xref="GeneID:22893"
                     /db_xref="HGNC:HGNC:29153"
                     /db_xref="MIM:613880"
ORIGIN      
        1 mgnsqnyfhs ssplcssiqe dlcvfilsvl iplglapats glstlsqgwk ysmthtrrks
       61 lpmlssgltg rreplqmeds nmeqgvegve pgmpespghl tgrrknyplr krplvpekpk
      121 ackvlltrle nvagprsade adelppdlpk ppspapssed pglaqprkrr laslnaealn
      181 nllleredts slagtrrsra gdphrsrdrd ratggwsssk krprlgdlgg gsrdlspepa
      241 pdegprrdgd papkrlasln aaaflklsqe relplrlpra haevdgrste ppapkaprpk
      301 wpkvngknyp kawqgassge aagppgwqgc pdepwpsatp cgpsvqpshq plskalespl
      361 glrphlpllm ggqaalkpep grpgeespap kqelhqpsfp tpqlsplpmp gnpadynglc
      421 vgpeltalgs fylycgqegl qcggyspcpm lpegklspva apheegllla pssvpsgtpf
      481 qhppwgssry cssedtgvng ysicgvlpls vthagttcgg cpykmpfaag crslgqlefp
      541 lpeaghpasp ahpllgcpvp svppaaepvp hlqtptsepq tvaracpqsa kppsgsksgl
      601 rtgsscrhta rskaarrpsh pkqprvqrpr prrrrrrrtn gwvpvgaace kavyvldepe
      661 pairksyqav erhgetirvr dtvllksgpr ktstpyvaki salwenpesg elmmsllwyy
      721 rpehlqggrs psmhenevfa srhqdqnsva cieekcyvlt faeycrfcam akrrgeglps
      781 rktalvppsa dystpphrtv pedtdpelvf lcrhvydfrh grilknpq
//
LOCUS       XP_047288198             795 aa            linear   PRI 05-AUG-2025
DEFINITION  bromo adjacent homology domain-containing 1 protein isoform X5
            [Homo sapiens].
ACCESSION   XP_047288198
VERSION     XP_047288198.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432242.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..795
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..795
                     /product="bromo adjacent homology domain-containing 1
                     protein isoform X5"
                     /calculated_mol_wt=86239
     Region          638..748
                     /region_name="BAH_BAHCC1"
                     /note="BAH, or Bromo Adjacent Homology domain, as present
                     in mammalian BAHCC1 and similar proteins. BAHCC1 stands
                     for BAH domain and coiled-coil containing 1. BAH domains
                     are found in a variety of proteins playing roles in
                     transcriptional silencing and the...; cd04714"
                     /db_xref="CDD:240065"
     CDS             1..795
                     /gene="BAHD1"
                     /coded_by="XM_047432242.1:33..2420"
                     /db_xref="GeneID:22893"
                     /db_xref="HGNC:HGNC:29153"
                     /db_xref="MIM:613880"
ORIGIN      
        1 mraphsasee gwkysmthtr rkslpmlssg ltgrreplqm edsnmeqgve gvepgmpesp
       61 ghltgrrkny plrkrplvpe kpkackvllt rlenvagprs adeadelppd lpkppspaps
      121 sedpglaqpr krrlaslnae alnnlllere dtsslagtrr sragdphrsr drdratggws
      181 sskkrprlgd lgggsrdlsp epapdegprr dgdpapkrla slnaaaflkl sqerelplrl
      241 prahaevdgr steppapkap rpkwpkvngk nypkawqgas sgeaagppgw qgcpdepwps
      301 atpcgpsvqp shqplskale splglrphlp llmggqaalk pepgrpgees papkqelhqp
      361 sfptpqlspl pmpgnpadyn glcvgpelta lgsfylycgq eglqcggysp cpmlpegkls
      421 pvaapheegl llapssvpsg tpfqhppwgs srycssedtg vngysicgvl plsvthagtt
      481 cggcpykmpf aaegcrslgq lefplpeagh paspahpllg cpvpsvppaa epvphlqtpt
      541 sepqtvarac pqsakppsgs ksglrtgssc rhtarskaar rpshpkqprv qrprprrrrr
      601 rrtngwvpvg aacekavyvl depepairks yqaverhget irvrdtvllk sgprktstpy
      661 vakisalwen pesgelmmsl lwyyrpehlq ggrspsmhep lqnevfasrh qdqnsvacie
      721 ekcyvltfae ycrfcamakr rgeglpsrkt alvppsadys tpphrtvped tdpelvflcr
      781 hvydfrhgri lknpq
//
LOCUS       XP_047288199             809 aa            linear   PRI 05-AUG-2025
DEFINITION  bromo adjacent homology domain-containing 1 protein isoform X6
            [Homo sapiens].
ACCESSION   XP_047288199
VERSION     XP_047288199.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432243.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..809
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..809
                     /product="bromo adjacent homology domain-containing 1
                     protein isoform X6"
                     /calculated_mol_wt=87677
     Region          652..762
                     /region_name="BAH_BAHCC1"
                     /note="BAH, or Bromo Adjacent Homology domain, as present
                     in mammalian BAHCC1 and similar proteins. BAHCC1 stands
                     for BAH domain and coiled-coil containing 1. BAH domains
                     are found in a variety of proteins playing roles in
                     transcriptional silencing and the...; cd04714"
                     /db_xref="CDD:240065"
     CDS             1..809
                     /gene="BAHD1"
                     /coded_by="XM_047432243.1:814..3243"
                     /db_xref="GeneID:22893"
                     /db_xref="HGNC:HGNC:29153"
                     /db_xref="MIM:613880"
ORIGIN      
        1 matphgppwn dldpsldgae acekgwkysm thtrrkslpm lssgltgrre plqmedsnme
       61 qgvegvepgm pespghltgr rknyplrkrp lvpekpkack vlltrlenva gprsadeade
      121 lppdlpkpps papssedpgl aqprkrrlas lnaealnnll leredtssla gtrrsragdp
      181 hrsrdrdrat ggwssskkrp rlgdlgggsr dlspepapde gprrdgdpap krlaslnaaa
      241 flklsqerel plrlprahae vdgrsteppa pkaprpkwpk vngknypkaw qgassgeaag
      301 ppgwqgcpde pwpsatpcgp svqpshqpls kalesplglr phlpllmggq aalkpepgrp
      361 geespapkqe lhqpsfptpq lsplpmpgnp adynglcvgp eltalgsfyl ycgqeglqcg
      421 gyspcpmlpe gklspvaaph eeglllapss vpsgtpfqhp pwgssrycss edtgvngysi
      481 cgvlplsvth agttcggcpy kmpfaaegcr slgqlefplp eaghpaspah pllgcpvpsv
      541 ppaaepvphl qtptsepqtv aracpqsakp psgsksglrt gsscrhtars kaarrpshpk
      601 qprvqrprpr rrrrrrtngw vpvgaaceka vyvldepepa irksyqaver hgetirvrdt
      661 vllksgprkt stpyvakisa lwenpesgel mmsllwyyrp ehlqggrsps mheplqnevf
      721 asrhqdqnsv acieekcyvl tfaeycrfca makrrgeglp srktalvpps adystpphrt
      781 vpedtdpelv flcrhvydfr hgrilknpq
//
LOCUS       XP_011519671             780 aa            linear   PRI 05-AUG-2025
DEFINITION  bromo adjacent homology domain-containing 1 protein isoform X7
            [Homo sapiens].
ACCESSION   XP_011519671
VERSION     XP_011519671.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521369.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..780
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..780
                     /product="bromo adjacent homology domain-containing 1
                     protein isoform X7"
                     /calculated_mol_wt=84521
     Region          623..733
                     /region_name="BAH_BAHCC1"
                     /note="BAH, or Bromo Adjacent Homology domain, as present
                     in mammalian BAHCC1 and similar proteins. BAHCC1 stands
                     for BAH domain and coiled-coil containing 1. BAH domains
                     are found in a variety of proteins playing roles in
                     transcriptional silencing and the...; cd04714"
                     /db_xref="CDD:240065"
     CDS             1..780
                     /gene="BAHD1"
                     /coded_by="XM_011521369.4:260..2602"
                     /db_xref="GeneID:22893"
                     /db_xref="HGNC:HGNC:29153"
                     /db_xref="MIM:613880"
ORIGIN      
        1 mthtrrkslp mlssgltgrr eplqmedsnm eqgvegvepg mpespghltg rrknyplrkr
       61 plvpekpkac kvlltrlenv agprsadead elppdlpkpp spapssedpg laqprkrrla
      121 slnaealnnl lleredtssl agtrrsragd phrsrdrdra tggwssskkr prlgdlgggs
      181 rdlspepapd egprrdgdpa pkrlaslnaa aflklsqere lplrlpraha evdgrstepp
      241 apkaprpkwp kvngknypka wqgassgeaa gppgwqgcpd epwpsatpcg psvqpshqpl
      301 skalesplgl rphlpllmgg qaalkpepgr pgeespapkq elhqpsfptp qlsplpmpgn
      361 padynglcvg peltalgsfy lycgqeglqc ggyspcpmlp egklspvaap heeglllaps
      421 svpsgtpfqh ppwgssrycs sedtgvngys icgvlplsvt hagttcggcp ykmpfaaegc
      481 rslgqlefpl peaghpaspa hpllgcpvps vppaaepvph lqtptsepqt varacpqsak
      541 ppsgsksglr tgsscrhtar skaarrpshp kqprvqrprp rrrrrrrtng wvpvgaacek
      601 avyvldepep airksyqave rhgetirvrd tvllksgprk tstpyvakis alwenpesge
      661 lmmsllwyyr pehlqggrsp smheplqnev fasrhqdqns vacieekcyv ltfaeycrfc
      721 amakrrgegl psrktalvpp sadystpphr tvpedtdpel vflcrhvydf rhgrilknpq
//
LOCUS       XP_047288200             780 aa            linear   PRI 05-AUG-2025
DEFINITION  bromo adjacent homology domain-containing 1 protein isoform X7
            [Homo sapiens].
ACCESSION   XP_047288200
VERSION     XP_047288200.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432244.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..780
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..780
                     /product="bromo adjacent homology domain-containing 1
                     protein isoform X7"
                     /calculated_mol_wt=84521
     Region          623..733
                     /region_name="BAH_BAHCC1"
                     /note="BAH, or Bromo Adjacent Homology domain, as present
                     in mammalian BAHCC1 and similar proteins. BAHCC1 stands
                     for BAH domain and coiled-coil containing 1. BAH domains
                     are found in a variety of proteins playing roles in
                     transcriptional silencing and the...; cd04714"
                     /db_xref="CDD:240065"
     CDS             1..780
                     /gene="BAHD1"
                     /coded_by="XM_047432244.1:373..2715"
                     /db_xref="GeneID:22893"
                     /db_xref="HGNC:HGNC:29153"
                     /db_xref="MIM:613880"
ORIGIN      
        1 mthtrrkslp mlssgltgrr eplqmedsnm eqgvegvepg mpespghltg rrknyplrkr
       61 plvpekpkac kvlltrlenv agprsadead elppdlpkpp spapssedpg laqprkrrla
      121 slnaealnnl lleredtssl agtrrsragd phrsrdrdra tggwssskkr prlgdlgggs
      181 rdlspepapd egprrdgdpa pkrlaslnaa aflklsqere lplrlpraha evdgrstepp
      241 apkaprpkwp kvngknypka wqgassgeaa gppgwqgcpd epwpsatpcg psvqpshqpl
      301 skalesplgl rphlpllmgg qaalkpepgr pgeespapkq elhqpsfptp qlsplpmpgn
      361 padynglcvg peltalgsfy lycgqeglqc ggyspcpmlp egklspvaap heeglllaps
      421 svpsgtpfqh ppwgssrycs sedtgvngys icgvlplsvt hagttcggcp ykmpfaaegc
      481 rslgqlefpl peaghpaspa hpllgcpvps vppaaepvph lqtptsepqt varacpqsak
      541 ppsgsksglr tgsscrhtar skaarrpshp kqprvqrprp rrrrrrrtng wvpvgaacek
      601 avyvldepep airksyqave rhgetirvrd tvllksgprk tstpyvakis alwenpesge
      661 lmmsllwyyr pehlqggrsp smheplqnev fasrhqdqns vacieekcyv ltfaeycrfc
      721 amakrrgegl psrktalvpp sadystpphr tvpedtdpel vflcrhvydf rhgrilknpq
//
LOCUS       XP_047288201             780 aa            linear   PRI 05-AUG-2025
DEFINITION  bromo adjacent homology domain-containing 1 protein isoform X7
            [Homo sapiens].
ACCESSION   XP_047288201
VERSION     XP_047288201.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432245.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..780
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..780
                     /product="bromo adjacent homology domain-containing 1
                     protein isoform X7"
                     /calculated_mol_wt=84521
     Region          623..733
                     /region_name="BAH_BAHCC1"
                     /note="BAH, or Bromo Adjacent Homology domain, as present
                     in mammalian BAHCC1 and similar proteins. BAHCC1 stands
                     for BAH domain and coiled-coil containing 1. BAH domains
                     are found in a variety of proteins playing roles in
                     transcriptional silencing and the...; cd04714"
                     /db_xref="CDD:240065"
     CDS             1..780
                     /gene="BAHD1"
                     /coded_by="XM_047432245.1:148..2490"
                     /db_xref="GeneID:22893"
                     /db_xref="HGNC:HGNC:29153"
                     /db_xref="MIM:613880"
ORIGIN      
        1 mthtrrkslp mlssgltgrr eplqmedsnm eqgvegvepg mpespghltg rrknyplrkr
       61 plvpekpkac kvlltrlenv agprsadead elppdlpkpp spapssedpg laqprkrrla
      121 slnaealnnl lleredtssl agtrrsragd phrsrdrdra tggwssskkr prlgdlgggs
      181 rdlspepapd egprrdgdpa pkrlaslnaa aflklsqere lplrlpraha evdgrstepp
      241 apkaprpkwp kvngknypka wqgassgeaa gppgwqgcpd epwpsatpcg psvqpshqpl
      301 skalesplgl rphlpllmgg qaalkpepgr pgeespapkq elhqpsfptp qlsplpmpgn
      361 padynglcvg peltalgsfy lycgqeglqc ggyspcpmlp egklspvaap heeglllaps
      421 svpsgtpfqh ppwgssrycs sedtgvngys icgvlplsvt hagttcggcp ykmpfaaegc
      481 rslgqlefpl peaghpaspa hpllgcpvps vppaaepvph lqtptsepqt varacpqsak
      541 ppsgsksglr tgsscrhtar skaarrpshp kqprvqrprp rrrrrrrtng wvpvgaacek
      601 avyvldepep airksyqave rhgetirvrd tvllksgprk tstpyvakis alwenpesge
      661 lmmsllwyyr pehlqggrsp smheplqnev fasrhqdqns vacieekcyv ltfaeycrfc
      721 amakrrgegl psrktalvpp sadystpphr tvpedtdpel vflcrhvydf rhgrilknpq
//
LOCUS       XP_047288202             779 aa            linear   PRI 05-AUG-2025
DEFINITION  bromo adjacent homology domain-containing 1 protein isoform X8
            [Homo sapiens].
ACCESSION   XP_047288202
VERSION     XP_047288202.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432246.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 5% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..779
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..779
                     /product="bromo adjacent homology domain-containing 1
                     protein isoform X8"
                     /calculated_mol_wt=84392
     Region          <170..552
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          622..732
                     /region_name="BAH_BAHCC1"
                     /note="BAH, or Bromo Adjacent Homology domain, as present
                     in mammalian BAHCC1 and similar proteins. BAHCC1 stands
                     for BAH domain and coiled-coil containing 1. BAH domains
                     are found in a variety of proteins playing roles in
                     transcriptional silencing and the...; cd04714"
                     /db_xref="CDD:240065"
     CDS             1..779
                     /gene="BAHD1"
                     /coded_by="XM_047432246.1:331..2670"
                     /db_xref="GeneID:22893"
                     /db_xref="HGNC:HGNC:29153"
                     /db_xref="MIM:613880"
ORIGIN      
        1 mthtrrkslp mlssgltgrr eplqmedsnm eqgvegvepg mpespghltg rrknyplrkr
       61 plvpekpkac kvlltrlenv agprsadead elppdlpkpp spapssedpg laqprkrrla
      121 slnaealnnl lleredtssl agtrrsragd phrsrdrdra tggwssskkr prlgdlgggs
      181 rdlspepapd egprrdgdpa pkrlaslnaa aflklsqere lplrlpraha evdgrstepp
      241 apkaprpkwp kvngknypka wqgassgeaa gppgwqgcpd epwpsatpcg psvqpshqpl
      301 skalesplgl rphlpllmgg qaalkpepgr pgeespapkq elhqpsfptp qlsplpmpgn
      361 padynglcvg peltalgsfy lycgqeglqc ggyspcpmlp egklspvaap heeglllaps
      421 svpsgtpfqh ppwgssrycs sedtgvngys icgvlplsvt hagttcggcp ykmpfaagcr
      481 slgqlefplp eaghpaspah pllgcpvpsv ppaaepvphl qtptsepqtv aracpqsakp
      541 psgsksglrt gsscrhtars kaarrpshpk qprvqrprpr rrrrrrtngw vpvgaaceka
      601 vyvldepepa irksyqaver hgetirvrdt vllksgprkt stpyvakisa lwenpesgel
      661 mmsllwyyrp ehlqggrsps mheplqnevf asrhqdqnsv acieekcyvl tfaeycrfca
      721 makrrgeglp srktalvpps adystpphrt vpedtdpelv flcrhvydfr hgrilknpq
//
LOCUS       XP_047288203             777 aa            linear   PRI 05-AUG-2025
DEFINITION  bromo adjacent homology domain-containing 1 protein isoform X9
            [Homo sapiens].
ACCESSION   XP_047288203
VERSION     XP_047288203.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432247.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 5% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..777
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..777
                     /product="bromo adjacent homology domain-containing 1
                     protein isoform X9"
                     /calculated_mol_wt=84183
     Region          623..730
                     /region_name="BAH_BAHCC1"
                     /note="BAH, or Bromo Adjacent Homology domain, as present
                     in mammalian BAHCC1 and similar proteins. BAHCC1 stands
                     for BAH domain and coiled-coil containing 1. BAH domains
                     are found in a variety of proteins playing roles in
                     transcriptional silencing and the...; cd04714"
                     /db_xref="CDD:240065"
     CDS             1..777
                     /gene="BAHD1"
                     /coded_by="XM_047432247.1:331..2664"
                     /db_xref="GeneID:22893"
                     /db_xref="HGNC:HGNC:29153"
                     /db_xref="MIM:613880"
ORIGIN      
        1 mthtrrkslp mlssgltgrr eplqmedsnm eqgvegvepg mpespghltg rrknyplrkr
       61 plvpekpkac kvlltrlenv agprsadead elppdlpkpp spapssedpg laqprkrrla
      121 slnaealnnl lleredtssl agtrrsragd phrsrdrdra tggwssskkr prlgdlgggs
      181 rdlspepapd egprrdgdpa pkrlaslnaa aflklsqere lplrlpraha evdgrstepp
      241 apkaprpkwp kvngknypka wqgassgeaa gppgwqgcpd epwpsatpcg psvqpshqpl
      301 skalesplgl rphlpllmgg qaalkpepgr pgeespapkq elhqpsfptp qlsplpmpgn
      361 padynglcvg peltalgsfy lycgqeglqc ggyspcpmlp egklspvaap heeglllaps
      421 svpsgtpfqh ppwgssrycs sedtgvngys icgvlplsvt hagttcggcp ykmpfaaegc
      481 rslgqlefpl peaghpaspa hpllgcpvps vppaaepvph lqtptsepqt varacpqsak
      541 ppsgsksglr tgsscrhtar skaarrpshp kqprvqrprp rrrrrrrtng wvpvgaacek
      601 avyvldepep airksyqave rhgetirvrd tvllksgprk tstpyvakis alwenpesge
      661 lmmsllwyyr pehlqggrsp smhenevfas rhqdqnsvac ieekcyvltf aeycrfcama
      721 krrgeglpsr ktalvppsad ystpphrtvp edtdpelvfl crhvydfrhg rilknpq
//
LOCUS       XP_047288205             776 aa            linear   PRI 05-AUG-2025
DEFINITION  bromo adjacent homology domain-containing 1 protein isoform X10
            [Homo sapiens].
ACCESSION   XP_047288205
VERSION     XP_047288205.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432249.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..776
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..776
                     /product="bromo adjacent homology domain-containing 1
                     protein isoform X10"
                     /calculated_mol_wt=84054
     Region          <170..552
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          622..729
                     /region_name="BAH_BAHCC1"
                     /note="BAH, or Bromo Adjacent Homology domain, as present
                     in mammalian BAHCC1 and similar proteins. BAHCC1 stands
                     for BAH domain and coiled-coil containing 1. BAH domains
                     are found in a variety of proteins playing roles in
                     transcriptional silencing and the...; cd04714"
                     /db_xref="CDD:240065"
     CDS             1..776
                     /gene="BAHD1"
                     /coded_by="XM_047432249.1:119..2449"
                     /db_xref="GeneID:22893"
                     /db_xref="HGNC:HGNC:29153"
                     /db_xref="MIM:613880"
ORIGIN      
        1 mthtrrkslp mlssgltgrr eplqmedsnm eqgvegvepg mpespghltg rrknyplrkr
       61 plvpekpkac kvlltrlenv agprsadead elppdlpkpp spapssedpg laqprkrrla
      121 slnaealnnl lleredtssl agtrrsragd phrsrdrdra tggwssskkr prlgdlgggs
      181 rdlspepapd egprrdgdpa pkrlaslnaa aflklsqere lplrlpraha evdgrstepp
      241 apkaprpkwp kvngknypka wqgassgeaa gppgwqgcpd epwpsatpcg psvqpshqpl
      301 skalesplgl rphlpllmgg qaalkpepgr pgeespapkq elhqpsfptp qlsplpmpgn
      361 padynglcvg peltalgsfy lycgqeglqc ggyspcpmlp egklspvaap heeglllaps
      421 svpsgtpfqh ppwgssrycs sedtgvngys icgvlplsvt hagttcggcp ykmpfaagcr
      481 slgqlefplp eaghpaspah pllgcpvpsv ppaaepvphl qtptsepqtv aracpqsakp
      541 psgsksglrt gsscrhtars kaarrpshpk qprvqrprpr rrrrrrtngw vpvgaaceka
      601 vyvldepepa irksyqaver hgetirvrdt vllksgprkt stpyvakisa lwenpesgel
      661 mmsllwyyrp ehlqggrsps mhenevfasr hqdqnsvaci eekcyvltfa eycrfcamak
      721 rrgeglpsrk talvppsady stpphrtvpe dtdpelvflc rhvydfrhgr ilknpq
//
LOCUS       XP_047288206             904 aa            linear   PRI 05-AUG-2025
DEFINITION  fanconi-associated nuclease 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047288206
VERSION     XP_047288206.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432250.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..904
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..904
                     /product="fanconi-associated nuclease 1 isoform X1"
                     /calculated_mol_wt=101796
     Region          41..62
                     /region_name="ZnF_Rad18"
                     /note="Rad18-like CCHC zinc finger; smart00734"
                     /db_xref="CDD:128973"
     Region          373..>830
                     /region_name="FAN1-like"
                     /note="repair nuclease FAN1; cd22326"
                     /db_xref="CDD:411730"
     Site            order(373..374,420,424..425,433,436,473..475,492..494,573,
                     576..578,581,620,672,675,678..679,681,706,710,713,
                     717..718,742,749,752,794..795)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:411730"
     CDS             1..904
                     /gene="FAN1"
                     /gene_synonym="hFAN1; KIAA1018; KMIN; MTMR15"
                     /coded_by="XM_047432250.1:153..2867"
                     /db_xref="GeneID:22909"
                     /db_xref="HGNC:HGNC:29170"
                     /db_xref="MIM:613534"
ORIGIN      
        1 mmsegkppdk krprrslsis knkkkasnsi iscfnnappa klacpvcskm vprydlnrhl
       61 demcanndfv qvdpgqvgli nsnvsmvdlt svtledvtpk kspppktnlt pgqsdsakre
      121 vkqkispyfk sndvvcknqd elrnrsvkvi clgslaskls rkyvkakksi dkdeefagss
      181 pqsskstvvk slidnsseie dedqilenss qkenvfkcds lkeecipehm vrgskimeae
      241 sqkatrecek saltpgfsdn aimlfspdft lrntlkstse dslvkqecik evvekreach
      301 ceevkmtvas eakiqlsdse akshssadda sawsniqeap lqddsclnnd iphsipleqg
      361 sscngpgqtt ghpyylrsfl vvlktvlene ddmllfdeqe kgivtkfyql satgqklyvr
      421 lfqrklswik mtkleyeeia ldltpvieel tnagflqtes elqelsevle llsapelksl
      481 aktfhlvnpn gqkqqlvdaf lklakqrsvc twgknkpgig avilkrakal agqsvrickg
      541 pravfsrill lfsltdsmed edaacggqgq lstvllvnlg rmefpsytin rkthifqdrd
      601 dliryaaath mlsdissama ngnweeakel aqcakrdwnr lknhpslrch edlplflrcf
      661 tvgwiytril srfveilqrl hmyeeavrel esllsqriyc pdsrgrwwdr lalnlhqhlk
      721 rleptikcit egladpevrt ghrlslyqra vrlrespsck kfkhlfqqlp emavqdvkhv
      781 titgrlcpqr gmcksvfvme ageaadpttv lcsveelala hyrrsgfdqg kgdvigedvq
      841 mpvkterysr pemvrnrrie ctfkaprdve tghsleeeag wdvgalkcfq lshepekhti
      901 pfpe
//
LOCUS       XP_011519672             623 aa            linear   PRI 05-AUG-2025
DEFINITION  fanconi-associated nuclease 1 isoform X2 [Homo sapiens].
ACCESSION   XP_011519672
VERSION     XP_011519672.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521370.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..623
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..623
                     /product="fanconi-associated nuclease 1 isoform X2"
                     /calculated_mol_wt=70544
     Region          9..623
                     /region_name="FAN1-like"
                     /note="repair nuclease FAN1; cd22326"
                     /db_xref="CDD:411730"
     Site            order(26,30..31,39,42,79..81,98..100,179,182..184,187,226,
                     278,281,284..285,287,312,316,319,323..324,348,355,358,
                     400..401,558,586,588,592)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:411730"
     Site            order(421,566,581,583,587)
                     /site_type="active"
                     /db_xref="CDD:411730"
     CDS             1..623
                     /gene="FAN1"
                     /gene_synonym="hFAN1; KIAA1018; KMIN; MTMR15"
                     /coded_by="XM_011521370.3:138..2009"
                     /db_xref="GeneID:22909"
                     /db_xref="HGNC:HGNC:29170"
                     /db_xref="MIM:613534"
ORIGIN      
        1 mrsyripllv issqeskttg qklyvrlfqr klswikmtkl eyeeialdlt pvieeltnag
       61 flqteselqe lsevlellsa pelkslaktf hlvnpngqkq qlvdaflkla kqrsvctwgk
      121 nkpgigavil krakalagqs vrickgprav fsrilllfsl tdsmededaa cggqgqlstv
      181 llvnlgrmef psytinrkth ifqdrddlir yaaathmlsd issamangnw eeakelaqca
      241 krdwnrlknh pslrchedlp lflrcftvgw iytrilsrfv eilqrlhmye eavrelesll
      301 sqriycpdsr grwwdrlaln lhqhlkrlep tikcitegla dpevrtghrl slyqravrlr
      361 espsckkfkh lfqqlpemav qdvkhvtitg rlcpqrgmck svfvmeagea adpttvlcsv
      421 eelalahyrr sgfdqgihge gstfstlygl llwdiifmdg ipdvfrnacq afpldlctds
      481 fftsrrpale arlqlihdap eeslrawvaa twheqegrva slvswdrfts lqqaqdlvsc
      541 lggpvlsgvc rhlaadfrhc rgglpdlvvw nsqsrhfklv evkgpndrls hkqmiwlael
      601 qklgaevevc hvvavgaksq sls
//
LOCUS       XP_024305642             622 aa            linear   PRI 05-AUG-2025
DEFINITION  fanconi-associated nuclease 1 isoform X3 [Homo sapiens].
ACCESSION   XP_024305642
VERSION     XP_024305642.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449874.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..622
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..622
                     /product="fanconi-associated nuclease 1 isoform X3"
                     /calculated_mol_wt=70167
     Region          19..622
                     /region_name="FAN1-like"
                     /note="repair nuclease FAN1; cd22326"
                     /db_xref="CDD:411730"
     Site            order(25,29..30,38,41,78..80,97..99,178,181..183,186,225,
                     277,280,283..284,286,311,315,318,322..323,347,354,357,
                     399..400,557,585,587,591)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:411730"
     Site            order(420,565,580,582,586)
                     /site_type="active"
                     /db_xref="CDD:411730"
     CDS             1..622
                     /gene="FAN1"
                     /gene_synonym="hFAN1; KIAA1018; KMIN; MTMR15"
                     /coded_by="XM_024449874.2:175..2043"
                     /db_xref="GeneID:22909"
                     /db_xref="HGNC:HGNC:29170"
                     /db_xref="MIM:613534"
ORIGIN      
        1 mpevlgsqgw lqassaatgq klyvrlfqrk lswikmtkle yeeialdltp vieeltnagf
       61 lqteselqel sevlellsap elkslaktfh lvnpngqkqq lvdaflklak qrsvctwgkn
      121 kpgigavilk rakalagqsv rickgpravf srilllfslt dsmededaac ggqgqlstvl
      181 lvnlgrmefp sytinrkthi fqdrddliry aaathmlsdi ssamangnwe eakelaqcak
      241 rdwnrlknhp slrchedlpl flrcftvgwi ytrilsrfve ilqrlhmyee avreleslls
      301 qriycpdsrg rwwdrlalnl hqhlkrlept ikciteglad pevrtghrls lyqravrlre
      361 spsckkfkhl fqqlpemavq dvkhvtitgr lcpqrgmcks vfvmeageaa dpttvlcsve
      421 elalahyrrs gfdqgihgeg stfstlygll lwdiifmdgi pdvfrnacqa fpldlctdsf
      481 ftsrrpalea rlqlihdape eslrawvaat wheqegrvas lvswdrftsl qqaqdlvscl
      541 ggpvlsgvcr hlaadfrhcr gglpdlvvwn sqsrhfklve vkgpndrlsh kqmiwlaelq
      601 klgaevevch vvavgaksqs ls
//
LOCUS       XP_011519674             609 aa            linear   PRI 05-AUG-2025
DEFINITION  fanconi-associated nuclease 1 isoform X4 [Homo sapiens].
ACCESSION   XP_011519674
VERSION     XP_011519674.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521372.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..609
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..609
                     /product="fanconi-associated nuclease 1 isoform X4"
                     /calculated_mol_wt=67587
     Region          41..62
                     /region_name="ZnF_Rad18"
                     /note="Rad18-like CCHC zinc finger; smart00734"
                     /db_xref="CDD:128973"
     Region          373..>604
                     /region_name="PDDEXK_nuclease-like"
                     /note="PDDEXK family nucleases; cl40440"
                     /db_xref="CDD:477358"
     CDS             1..609
                     /gene="FAN1"
                     /gene_synonym="hFAN1; KIAA1018; KMIN; MTMR15"
                     /coded_by="XM_011521372.3:153..1982"
                     /db_xref="GeneID:22909"
                     /db_xref="HGNC:HGNC:29170"
                     /db_xref="MIM:613534"
ORIGIN      
        1 mmsegkppdk krprrslsis knkkkasnsi iscfnnappa klacpvcskm vprydlnrhl
       61 demcanndfv qvdpgqvgli nsnvsmvdlt svtledvtpk kspppktnlt pgqsdsakre
      121 vkqkispyfk sndvvcknqd elrnrsvkvi clgslaskls rkyvkakksi dkdeefagss
      181 pqsskstvvk slidnsseie dedqilenss qkenvfkcds lkeecipehm vrgskimeae
      241 sqkatrecek saltpgfsdn aimlfspdft lrntlkstse dslvkqecik evvekreach
      301 ceevkmtvas eakiqlsdse akshssadda sawsniqeap lqddsclnnd iphsipleqg
      361 sscngpgqtt ghpyylrsfl vvlktvlene ddmllfdeqe kgivtkfyql satgqklyvr
      421 lfqrklswik mtkleyeeia ldltpvieel tnagflqtes elqelsevle llsapelksl
      481 aktfhlvnpn gqkqqlvdaf lklakqrsvc twgknkpgig avilkrakal agqsvrickg
      541 pravfsrill lfsltdsmed edaacggqgq lstvllvnlg rmefpsytin rkthifqdrd
      601 dlirvrssg
//
LOCUS       XP_016877502             460 aa            linear   PRI 05-AUG-2025
DEFINITION  fanconi-associated nuclease 1 isoform X5 [Homo sapiens].
ACCESSION   XP_016877502
VERSION     XP_016877502.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022013.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..460
                     /product="fanconi-associated nuclease 1 isoform X5"
                     /calculated_mol_wt=52217
     Region          <1..460
                     /region_name="FAN1-like"
                     /note="repair nuclease FAN1; cd22326"
                     /db_xref="CDD:411730"
     CDS             1..460
                     /gene="FAN1"
                     /gene_synonym="hFAN1; KIAA1018; KMIN; MTMR15"
                     /coded_by="XM_017022013.2:185..1567"
                     /db_xref="GeneID:22909"
                     /db_xref="HGNC:HGNC:29170"
                     /db_xref="MIM:613534"
ORIGIN      
        1 mededaacgg qgqlstvllv nlgrmefpsy tinrkthifq drddliryaa athmlsdiss
       61 amangnweea kelaqcakrd wnrlknhpsl rchedlplfl rcftvgwiyt rilsrfveil
      121 qrlhmyeeav relesllsqr iycpdsrgrw wdrlalnlhq hlkrleptik citegladpe
      181 vrtghrlsly qravrlresp sckkfkhlfq qlpemavqdv khvtitgrlc pqrgmcksvf
      241 vmeageaadp ttvlcsveel alahyrrsgf dqgihgegst fstlyglllw diifmdgipd
      301 vfrnacqafp ldlctdsfft srrpalearl qlihdapees lrawvaatwh eqegrvaslv
      361 swdrftslqq aqdlvsclgg pvlsgvcrhl aadfrhcrgg lpdlvvwnsq srhfklvevk
      421 gpndrlshkq miwlaelqkl gaevevchvv avgaksqsls
//
LOCUS       XP_006720500            1710 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 152 kDa isoform X1 [Homo sapiens].
ACCESSION   XP_006720500
VERSION     XP_006720500.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720437.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1710
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1710
                     /product="centrosomal protein of 152 kDa isoform X1"
                     /calculated_mol_wt=195496
     Region          <218..>781
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          <664..1236
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     CDS             1..1710
                     /gene="CEP152"
                     /gene_synonym="MCPH4; MCPH9; SCKL5"
                     /coded_by="XM_006720437.4:384..5516"
                     /db_xref="GeneID:22995"
                     /db_xref="HGNC:HGNC:29298"
                     /db_xref="MIM:613529"
ORIGIN      
        1 msldfgsval pvqnedeeyd eedyerekel qqlltdlphd mldddlsspe lqysdcsedg
       61 tdgqphhpeq lemswneqml pksqsvngyn eiqslyagek cgnvweenrs ktedrhpvyh
      121 peeggdeggs gysppskceq tdlyhlpenf rpytngqkqe fnnqatnvik fsdpqwnhfq
      181 gpscqglepy nkvtykpyqs saqnngspaq eitgsdtfeg lqqqflgane nsaenmqiiq
      241 lqvlnkaker qlenliekln eserqiryln hqlviikdek dgltlslres qklfqngker
      301 eiqleaqika letqiqalkv neeqmikksr ttemaleslk qqlvdlhhse slqrareqhe
      361 sivmgltkky eeqvlslqkn ldatvtalke qedicsrlkd hvkqlernqe aiklekteii
      421 nkltrslees qkqcahllqs gsvqevaqlq fqlqqaqkah amsanmnkal qeeltelkde
      481 islyesaakl gihpsdsege lnieltesyv dlgikkvnwk kskvtsivqe edpneelskd
      541 efilklkaev qrllgsnsmk rhlvsqlqnd lkdchkkied lhqvkkdeks ievetktdts
      601 ekpknqlwpe sstsdvvrdd illlkneiqv lqqqnqelke tegklrntnq dlcnqmrqmv
      661 qdfdhdkqea vdrcertyqq hheamktqir esllakhale kqqlfeayer thlqlrseld
      721 klnkevtavq ecylevcrek dnleltlrkt tekeqqtqek ikekliqqle kewqskldqt
      781 ikamkkktld cgsqtdqvtt sdviskkema imieeqkcti qqnleqekdi aikgamkkle
      841 ielelkhcen itkqveiavq nahqrwlgel pelaeyqalv kaeqkkweeq hevsvnkris
      901 favseakekw kselenmrkn ilpgkeleek ihslqkelel kneevpvvir aelakarsew
      961 nkekqeeihr iqeqneqdyr qflddhrnki nevlaaaked fmkqktelll qketelqtcl
     1021 dqsrrewtmq eakriqleiy qyeediltvl gvllsdtqke hisdsedkql leimstcssk
     1081 wmsvqyfekl kgciqkafqd tlpllvenad pewkkrnmae lskdsasqgt gqgdpgpaag
     1141 hhaqplalqa teaeadkkkv leikdlccgh cfqelekakq ecqdlkgkle kccrhlqhle
     1201 rkhkavveki geennkvvee lieenndmkn kleelqtlck tpprslsaga ienaclpcsg
     1261 galeelrgqy ikavkkikcd mlryiqeske raaemvkaev lrerqetark mrkyyliclq
     1321 qilqddgkeg aekkimnaas klatmaklle tpissksqsk ttqsalplts emliavkksk
     1381 rndvnqkipc ciesksnsvn titrtlceqa pkrraacnlq rllensehqs ikhvgsketh
     1441 lefqfgdgsc khlnslprnv spefvpcege ggfglhkkkd llsdngsesl phsaaypflg
     1501 tlgnkpsprc tpgpsesgcm hitfrdsner lglkvykcnp lmesenaase ksqgldvqep
     1561 pvkdggdlsd clgwpsssat lsfdsreasf vhgrpqgtle ipsesvkskq fspsgylsdt
     1621 eesnmicqtm kcqryqtpyl seettylepg kisvncghps rhkadrlksd fkklsstlps
     1681 svcqqpsrkl ivplssqqds gfdspfvnld
//
LOCUS       XP_011519675            1700 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 152 kDa isoform X2 [Homo sapiens].
ACCESSION   XP_011519675
VERSION     XP_011519675.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521373.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1700
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1700
                     /product="centrosomal protein of 152 kDa isoform X2"
                     /calculated_mol_wt=194463
     Region          <218..>781
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          <664..1236
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     CDS             1..1700
                     /gene="CEP152"
                     /gene_synonym="MCPH4; MCPH9; SCKL5"
                     /coded_by="XM_011521373.4:117..5219"
                     /db_xref="GeneID:22995"
                     /db_xref="HGNC:HGNC:29298"
                     /db_xref="MIM:613529"
ORIGIN      
        1 msldfgsval pvqnedeeyd eedyerekel qqlltdlphd mldddlsspe lqysdcsedg
       61 tdgqphhpeq lemswneqml pksqsvngyn eiqslyagek cgnvweenrs ktedrhpvyh
      121 peeggdeggs gysppskceq tdlyhlpenf rpytngqkqe fnnqatnvik fsdpqwnhfq
      181 gpscqglepy nkvtykpyqs saqnngspaq eitgsdtfeg lqqqflgane nsaenmqiiq
      241 lqvlnkaker qlenliekln eserqiryln hqlviikdek dgltlslres qklfqngker
      301 eiqleaqika letqiqalkv neeqmikksr ttemaleslk qqlvdlhhse slqrareqhe
      361 sivmgltkky eeqvlslqkn ldatvtalke qedicsrlkd hvkqlernqe aiklekteii
      421 nkltrslees qkqcahllqs gsvqevaqlq fqlqqaqkah amsanmnkal qeeltelkde
      481 islyesaakl gihpsdsege lnieltesyv dlgikkvnwk kskvtsivqe edpneelskd
      541 efilklkaev qrllgsnsmk rhlvsqlqnd lkdchkkied lhqvkkdeks ievetktdts
      601 ekpknqlwpe sstsdvvrdd illlkneiqv lqqqnqelke tegklrntnq dlcnqmrqmv
      661 qdfdhdkqea vdrcertyqq hheamktqir esllakhale kqqlfeayer thlqlrseld
      721 klnkevtavq ecylevcrek dnleltlrkt tekeqqtqek ikekliqqle kewqskldqt
      781 ikamkkktld cgsqtdqvtt sdviskkema imieeqkcti qqnleqekdi aikgamkkle
      841 ielelkhcen itkqveiavq nahqrwlgel pelaeyqalv kaeqkkweeq hevsvnkris
      901 favseakekw kselenmrkn ilpgkeleek ihslqkelel kneevpvvir aelakarsew
      961 nkekqeeihr iqeqneqdyr qflddhrnki nevlaaaked fmkqktelll qketelqtcl
     1021 dqsrrewtmq eakriqleiy qyeediltvl gvllsdtqke hisdsedkql leimstcssk
     1081 wmsvqyfekl kgciqkafqd tlpllvenad pewkkrnmae lskdsasqgt gqgdpgpaag
     1141 hhaqplalqa teaeadkkkv leikdlccgh cfqelekakq ecqdlkgkle kccrhlqhle
     1201 rkhkavveki geennkvvee lieenndmkn kleelqtlck tpprslsaga ienaclpcsg
     1261 galeelrgqy ikavkkikcd mlryiqeske raaemvkaev lrerqetark mrkyyliclq
     1321 qilqddgkeg aekkimnaas klatmaklle tpistlplts emliavkksk rndvnqkipc
     1381 ciesksnsvn titrtlceqa pkrraacnlq rllensehqs ikhvgsketh lefqfgdgsc
     1441 khlnslprnv spefvpcege ggfglhkkkd llsdngsesl phsaaypflg tlgnkpsprc
     1501 tpgpsesgcm hitfrdsner lglkvykcnp lmesenaase ksqgldvqep pvkdggdlsd
     1561 clgwpsssat lsfdsreasf vhgrpqgtle ipsesvkskq fspsgylsdt eesnmicqtm
     1621 kcqryqtpyl seettylepg kisvncghps rhkadrlksd fkklsstlps svcqqpsrkl
     1681 ivplssqqds gfdspfvnld
//
LOCUS       XP_024305643            1644 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 152 kDa isoform X3 [Homo sapiens].
ACCESSION   XP_024305643
VERSION     XP_024305643.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449875.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1644
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1644
                     /product="centrosomal protein of 152 kDa isoform X3"
                     /calculated_mol_wt=187907
     Region          <218..>781
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          714..>1024
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     CDS             1..1644
                     /gene="CEP152"
                     /gene_synonym="MCPH4; MCPH9; SCKL5"
                     /coded_by="XM_024449875.2:117..5051"
                     /db_xref="GeneID:22995"
                     /db_xref="HGNC:HGNC:29298"
                     /db_xref="MIM:613529"
ORIGIN      
        1 msldfgsval pvqnedeeyd eedyerekel qqlltdlphd mldddlsspe lqysdcsedg
       61 tdgqphhpeq lemswneqml pksqsvngyn eiqslyagek cgnvweenrs ktedrhpvyh
      121 peeggdeggs gysppskceq tdlyhlpenf rpytngqkqe fnnqatnvik fsdpqwnhfq
      181 gpscqglepy nkvtykpyqs saqnngspaq eitgsdtfeg lqqqflgane nsaenmqiiq
      241 lqvlnkaker qlenliekln eserqiryln hqlviikdek dgltlslres qklfqngker
      301 eiqleaqika letqiqalkv neeqmikksr ttemaleslk qqlvdlhhse slqrareqhe
      361 sivmgltkky eeqvlslqkn ldatvtalke qedicsrlkd hvkqlernqe aiklekteii
      421 nkltrslees qkqcahllqs gsvqevaqlq fqlqqaqkah amsanmnkal qeeltelkde
      481 islyesaakl gihpsdsege lnieltesyv dlgikkvnwk kskvtsivqe edpneelskd
      541 efilklkaev qrllgsnsmk rhlvsqlqnd lkdchkkied lhqvkkdeks ievetktdts
      601 ekpknqlwpe sstsdvvrdd illlkneiqv lqqqnqelke tegklrntnq dlcnqmrqmv
      661 qdfdhdkqea vdrcertyqq hheamktqir esllakhale kqqlfeayer thlqlrseld
      721 klnkevtavq ecylevcrek dnleltlrkt tekeqqtqek ikekliqqle kewqskldqt
      781 ikamkkktld cgsqtdqvtt sdviskkema imieeqkcti qqnleqekdi aikgamkkle
      841 ielelkhcen itkqveiavq nahqrwlgel pelaeyqalv kaeqkkweeq hevsvnkris
      901 favseakekw kselenmrkn ilpgkeleek ihslqkelel kneevpvvir aelakarsew
      961 nkekqeeihr iqeqneqdyr qflddhrnki nevlaaaked fmkqktelll qketelqtcl
     1021 dqsrrewtmq eakriqleiy qyeediltvl gvllsdtqke hisdsedkql leimstcssk
     1081 wmsvqyfekl kgciqkafqd tlpllvenad pewkkrnmae lskdsasqgt gqgdpgpaag
     1141 hhaqplalqa teaeaeennk vveelieenn dmknkleelq tlcktpprsl sagaienacl
     1201 pcsggaleel rgqyikavkk ikcdmlryiq eskeraaemv kaevlrerqe tarkmrkyyl
     1261 iclqqilqdd gkegaekkim naasklatma klletpistl pltsemliav kkskrndvnq
     1321 kipcciesks nsvntitrtl ceqapkrraa cnlqrllens ehqsikhvgs kethlefqfg
     1381 dgsckhlnsl prnvspefvp cegeggfglh kkkdllsdng seslphsaay pflgtlgnkp
     1441 sprctpgpse sgcmhitfrd snerlglkvy kcnplmesen aaseksqgld vqeppvkdgg
     1501 dlsdclgwps ssatlsfdsr easfvhgrpq gtleipsesv kskqfspsgy lsdteesnmi
     1561 cqtmkcqryq tpylseetty lepgkisvnc ghpsrhkadr lksdfkklss tlpssvcqqp
     1621 srklivplss qqdsgfdspf vnld
//
LOCUS       XP_011519676            1401 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 152 kDa isoform X4 [Homo sapiens].
ACCESSION   XP_011519676
VERSION     XP_011519676.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521374.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1401
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1401
                     /product="centrosomal protein of 152 kDa isoform X4"
                     /calculated_mol_wt=161426
     Region          <295..1045
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     CDS             1..1401
                     /gene="CEP152"
                     /gene_synonym="MCPH4; MCPH9; SCKL5"
                     /coded_by="XM_011521374.4:117..4322"
                     /db_xref="GeneID:22995"
                     /db_xref="HGNC:HGNC:29298"
                     /db_xref="MIM:613529"
ORIGIN      
        1 msldfgsval pvqnedeeyd eedyerekel qqlltdlphd mldddlsspe lqysdcsedg
       61 tdgqphhpeq lemswneqml pksqsvngyn eiqslyagek cgnvweenrs ktedrhpvyh
      121 peeggdeggs gysppskceq tdlyhlpenf rpytngqkqe fnnqatnvik fsdpqwnhfq
      181 gpscqglepy nkvtykpyqs saqnngspaq eitgsdtfeg lqqqflgane nsaenmqiiq
      241 lqvlnkaker qlenliekln eserqiryln hqlviikdek dgltlslres qklfqngker
      301 eiqleaqika letqiqalkv neeqmikksr ttemaleslk qqlvdlhhse slqrareqhe
      361 sivmgltkky eeqvlslqkn ldatvtalke qedicsrlkd hvkqlernqe aiklekteii
      421 nkltrslees qkqcahllqs gsvqevaqlq fqlqqaqkah amsanmnkal qeeltelkde
      481 islyesaakl gihpsdsege lnieltesyv dlgikkvnwk kskvtsivqe edpneelskd
      541 efilklkaev qrllgsnsmk rhlvsqlqnd lkdchkkied lhqvkkdeks ievetktdts
      601 ekpknqlwpe sstsdvvrdd illlkneiqv lqqqnqelke tegklrntnq dlcnqmrqmv
      661 qdfdhdkqea vdrcertyqq hheamktqir esllakhale kqqlfeayer thlqlrseld
      721 klnkevtavq ecylevcrek dnleltlrkt tekeqqtqek ikekliqqle kewqskldqt
      781 ikamkkktld cgsqtdqvtt sdviskkema imieeqkcti qqnleqekdi aikgamkkle
      841 ielelkhcen itkqveiavq nahqrwlgel pelaeyqalv kaeqkkweeq hevsvnkris
      901 favseakekw kselenmrkn ilpgkeleek ihslqkelel kneevpvvir aelakarsew
      961 nkekqeeihr iqeqneqdyr qflddhrnki nevlaaaked fmkqktelll qketelqtcl
     1021 dqsrrewtmq eakriqleiy qyeediltvl gvllsdtqke hisdsedkql leimstcssk
     1081 wmsvqyfekl kgciqkafqd tlpllvenad pewkkrnmae lskdsasqgt gqgdpgpaag
     1141 hhaqplalqa teaeadkkkv leikdlccgh cfqelekakq ecqdlkgkle kccrhlqhle
     1201 rkhkavveki geennkvvee lieenndmkn kleelqtlck tpprslsaga ienaclpcsg
     1261 galeelrgqy ikavkkikcd mlryiqeske raaemvkaev lrerqetark mrkyyliclq
     1321 qilqddgkeg aekkimnaas klatmaklle tpissksqsk ttqsgdgill chpgwravaq
     1381 itateprlql lgsndpprsa s
//
LOCUS       XP_011519677            1397 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 152 kDa isoform X5 [Homo sapiens].
ACCESSION   XP_011519677
VERSION     XP_011519677.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521375.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1397
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1397
                     /product="centrosomal protein of 152 kDa isoform X5"
                     /calculated_mol_wt=161089
     Region          <295..1045
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     CDS             1..1397
                     /gene="CEP152"
                     /gene_synonym="MCPH4; MCPH9; SCKL5"
                     /coded_by="XM_011521375.4:117..4310"
                     /db_xref="GeneID:22995"
                     /db_xref="HGNC:HGNC:29298"
                     /db_xref="MIM:613529"
ORIGIN      
        1 msldfgsval pvqnedeeyd eedyerekel qqlltdlphd mldddlsspe lqysdcsedg
       61 tdgqphhpeq lemswneqml pksqsvngyn eiqslyagek cgnvweenrs ktedrhpvyh
      121 peeggdeggs gysppskceq tdlyhlpenf rpytngqkqe fnnqatnvik fsdpqwnhfq
      181 gpscqglepy nkvtykpyqs saqnngspaq eitgsdtfeg lqqqflgane nsaenmqiiq
      241 lqvlnkaker qlenliekln eserqiryln hqlviikdek dgltlslres qklfqngker
      301 eiqleaqika letqiqalkv neeqmikksr ttemaleslk qqlvdlhhse slqrareqhe
      361 sivmgltkky eeqvlslqkn ldatvtalke qedicsrlkd hvkqlernqe aiklekteii
      421 nkltrslees qkqcahllqs gsvqevaqlq fqlqqaqkah amsanmnkal qeeltelkde
      481 islyesaakl gihpsdsege lnieltesyv dlgikkvnwk kskvtsivqe edpneelskd
      541 efilklkaev qrllgsnsmk rhlvsqlqnd lkdchkkied lhqvkkdeks ievetktdts
      601 ekpknqlwpe sstsdvvrdd illlkneiqv lqqqnqelke tegklrntnq dlcnqmrqmv
      661 qdfdhdkqea vdrcertyqq hheamktqir esllakhale kqqlfeayer thlqlrseld
      721 klnkevtavq ecylevcrek dnleltlrkt tekeqqtqek ikekliqqle kewqskldqt
      781 ikamkkktld cgsqtdqvtt sdviskkema imieeqkcti qqnleqekdi aikgamkkle
      841 ielelkhcen itkqveiavq nahqrwlgel pelaeyqalv kaeqkkweeq hevsvnkris
      901 favseakekw kselenmrkn ilpgkeleek ihslqkelel kneevpvvir aelakarsew
      961 nkekqeeihr iqeqneqdyr qflddhrnki nevlaaaked fmkqktelll qketelqtcl
     1021 dqsrrewtmq eakriqleiy qyeediltvl gvllsdtqke hisdsedkql leimstcssk
     1081 wmsvqyfekl kgciqkafqd tlpllvenad pewkkrnmae lskdsasqgt gqgdpgpaag
     1141 hhaqplalqa teaeadkkkv leikdlccgh cfqelekakq ecqdlkgkle kccrhlqhle
     1201 rkhkavveki geennkvvee lieenndmkn kleelqtlck tpprslsaga ienaclpcsg
     1261 galeelrgqy ikavkkikcd mlryiqeske raaemvkaev lrerqetark mrkyyliclq
     1321 qilqddgkeg aekkimnaas klatmaklle tpiskpdnlg gdgetarcil lllitisksk
     1381 nregklfglg klchlns
//
LOCUS       XP_047288208            1391 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 152 kDa isoform X6 [Homo sapiens].
ACCESSION   XP_047288208
VERSION     XP_047288208.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432252.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1391
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1391
                     /product="centrosomal protein of 152 kDa isoform X6"
                     /calculated_mol_wt=160462
     Region          <295..1045
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     CDS             1..1391
                     /gene="CEP152"
                     /gene_synonym="MCPH4; MCPH9; SCKL5"
                     /coded_by="XM_047432252.1:117..4292"
                     /db_xref="GeneID:22995"
                     /db_xref="HGNC:HGNC:29298"
                     /db_xref="MIM:613529"
ORIGIN      
        1 msldfgsval pvqnedeeyd eedyerekel qqlltdlphd mldddlsspe lqysdcsedg
       61 tdgqphhpeq lemswneqml pksqsvngyn eiqslyagek cgnvweenrs ktedrhpvyh
      121 peeggdeggs gysppskceq tdlyhlpenf rpytngqkqe fnnqatnvik fsdpqwnhfq
      181 gpscqglepy nkvtykpyqs saqnngspaq eitgsdtfeg lqqqflgane nsaenmqiiq
      241 lqvlnkaker qlenliekln eserqiryln hqlviikdek dgltlslres qklfqngker
      301 eiqleaqika letqiqalkv neeqmikksr ttemaleslk qqlvdlhhse slqrareqhe
      361 sivmgltkky eeqvlslqkn ldatvtalke qedicsrlkd hvkqlernqe aiklekteii
      421 nkltrslees qkqcahllqs gsvqevaqlq fqlqqaqkah amsanmnkal qeeltelkde
      481 islyesaakl gihpsdsege lnieltesyv dlgikkvnwk kskvtsivqe edpneelskd
      541 efilklkaev qrllgsnsmk rhlvsqlqnd lkdchkkied lhqvkkdeks ievetktdts
      601 ekpknqlwpe sstsdvvrdd illlkneiqv lqqqnqelke tegklrntnq dlcnqmrqmv
      661 qdfdhdkqea vdrcertyqq hheamktqir esllakhale kqqlfeayer thlqlrseld
      721 klnkevtavq ecylevcrek dnleltlrkt tekeqqtqek ikekliqqle kewqskldqt
      781 ikamkkktld cgsqtdqvtt sdviskkema imieeqkcti qqnleqekdi aikgamkkle
      841 ielelkhcen itkqveiavq nahqrwlgel pelaeyqalv kaeqkkweeq hevsvnkris
      901 favseakekw kselenmrkn ilpgkeleek ihslqkelel kneevpvvir aelakarsew
      961 nkekqeeihr iqeqneqdyr qflddhrnki nevlaaaked fmkqktelll qketelqtcl
     1021 dqsrrewtmq eakriqleiy qyeediltvl gvllsdtqke hisdsedkql leimstcssk
     1081 wmsvqyfekl kgciqkafqd tlpllvenad pewkkrnmae lskdsasqgt gqgdpgpaag
     1141 hhaqplalqa teaeadkkkv leikdlccgh cfqelekakq ecqdlkgkle kccrhlqhle
     1201 rkhkavveki geennkvvee lieenndmkn kleelqtlck tpprslsaga ienaclpcsg
     1261 galeelrgqy ikavkkikcd mlryiqeske raaemvkaev lrerqetark mrkyyliclq
     1321 qilqddgkeg aekkimnaas klatmaklle tpisrdgill chpgwravaq itateprlql
     1381 lgsndpprsa s
//
LOCUS       XP_047288209            1345 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 152 kDa isoform X7 [Homo sapiens].
ACCESSION   XP_047288209
VERSION     XP_047288209.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432253.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1345
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1345
                     /product="centrosomal protein of 152 kDa isoform X7"
                     /calculated_mol_wt=154870
     Region          <295..1045
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     CDS             1..1345
                     /gene="CEP152"
                     /gene_synonym="MCPH4; MCPH9; SCKL5"
                     /coded_by="XM_047432253.1:117..4154"
                     /db_xref="GeneID:22995"
                     /db_xref="HGNC:HGNC:29298"
                     /db_xref="MIM:613529"
ORIGIN      
        1 msldfgsval pvqnedeeyd eedyerekel qqlltdlphd mldddlsspe lqysdcsedg
       61 tdgqphhpeq lemswneqml pksqsvngyn eiqslyagek cgnvweenrs ktedrhpvyh
      121 peeggdeggs gysppskceq tdlyhlpenf rpytngqkqe fnnqatnvik fsdpqwnhfq
      181 gpscqglepy nkvtykpyqs saqnngspaq eitgsdtfeg lqqqflgane nsaenmqiiq
      241 lqvlnkaker qlenliekln eserqiryln hqlviikdek dgltlslres qklfqngker
      301 eiqleaqika letqiqalkv neeqmikksr ttemaleslk qqlvdlhhse slqrareqhe
      361 sivmgltkky eeqvlslqkn ldatvtalke qedicsrlkd hvkqlernqe aiklekteii
      421 nkltrslees qkqcahllqs gsvqevaqlq fqlqqaqkah amsanmnkal qeeltelkde
      481 islyesaakl gihpsdsege lnieltesyv dlgikkvnwk kskvtsivqe edpneelskd
      541 efilklkaev qrllgsnsmk rhlvsqlqnd lkdchkkied lhqvkkdeks ievetktdts
      601 ekpknqlwpe sstsdvvrdd illlkneiqv lqqqnqelke tegklrntnq dlcnqmrqmv
      661 qdfdhdkqea vdrcertyqq hheamktqir esllakhale kqqlfeayer thlqlrseld
      721 klnkevtavq ecylevcrek dnleltlrkt tekeqqtqek ikekliqqle kewqskldqt
      781 ikamkkktld cgsqtdqvtt sdviskkema imieeqkcti qqnleqekdi aikgamkkle
      841 ielelkhcen itkqveiavq nahqrwlgel pelaeyqalv kaeqkkweeq hevsvnkris
      901 favseakekw kselenmrkn ilpgkeleek ihslqkelel kneevpvvir aelakarsew
      961 nkekqeeihr iqeqneqdyr qflddhrnki nevlaaaked fmkqktelll qketelqtcl
     1021 dqsrrewtmq eakriqleiy qyeediltvl gvllsdtqke hisdsedkql leimstcssk
     1081 wmsvqyfekl kgciqkafqd tlpllvenad pewkkrnmae lskdsasqgt gqgdpgpaag
     1141 hhaqplalqa teaeaeennk vveelieenn dmknkleelq tlcktpprsl sagaienacl
     1201 pcsggaleel rgqyikavkk ikcdmlryiq eskeraaemv kaevlrerqe tarkmrkyyl
     1261 iclqqilqdd gkegaekkim naasklatma klletpissk sqskttqsgd gillchpgwr
     1321 avaqitatep rlqllgsndp prsas
//
LOCUS       XP_011519681            1341 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 152 kDa isoform X8 [Homo sapiens].
ACCESSION   XP_011519681
VERSION     XP_011519681.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521379.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1341
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1341
                     /product="centrosomal protein of 152 kDa isoform X8"
                     /calculated_mol_wt=155118
     Region          <295..1045
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     CDS             1..1341
                     /gene="CEP152"
                     /gene_synonym="MCPH4; MCPH9; SCKL5"
                     /coded_by="XM_011521379.4:117..4142"
                     /db_xref="GeneID:22995"
                     /db_xref="HGNC:HGNC:29298"
                     /db_xref="MIM:613529"
ORIGIN      
        1 msldfgsval pvqnedeeyd eedyerekel qqlltdlphd mldddlsspe lqysdcsedg
       61 tdgqphhpeq lemswneqml pksqsvngyn eiqslyagek cgnvweenrs ktedrhpvyh
      121 peeggdeggs gysppskceq tdlyhlpenf rpytngqkqe fnnqatnvik fsdpqwnhfq
      181 gpscqglepy nkvtykpyqs saqnngspaq eitgsdtfeg lqqqflgane nsaenmqiiq
      241 lqvlnkaker qlenliekln eserqiryln hqlviikdek dgltlslres qklfqngker
      301 eiqleaqika letqiqalkv neeqmikksr ttemaleslk qqlvdlhhse slqrareqhe
      361 sivmgltkky eeqvlslqkn ldatvtalke qedicsrlkd hvkqlernqe aiklekteii
      421 nkltrslees qkqcahllqs gsvqevaqlq fqlqqaqkah amsanmnkal qeeltelkde
      481 islyesaakl gihpsdsege lnieltesyv dlgikkvnwk kskvtsivqe edpneelskd
      541 efilklkaev qrllgsnsmk rhlvsqlqnd lkdchkkied lhqvkkdeks ievetktdts
      601 ekpknqlwpe sstsdvvrdd illlkneiqv lqqqnqelke tegklrntnq dlcnqmrqmv
      661 qdfdhdkqea vdrcertyqq hheamktqir esllakhale kqqlfeayer thlqlrseld
      721 klnkevtavq ecylevcrek dnleltlrkt tekeqqtqek ikekliqqle kewqskldqt
      781 ikamkkktld cgsqtdqvtt sdviskkema imieeqkcti qqnleqekdi aikgamkkle
      841 ielelkhcen itkqveiavq nahqrwlgel pelaeyqalv kaeqkkweeq hevsvnkris
      901 favseakekw kselenmrkn ilpgkeleek ihslqkelel kneevpvvir aelakarsew
      961 nkekqeeihr iqeqneqdyr qflddhrnki nevlaaaked fmkqktelll qketelqtcl
     1021 dqsrrewtmq eakriqleiy qyeediltvl gvllsdtqke hisdsedkql leimstcssk
     1081 wmsvqyfekl kgciqkafqd tlpllvenad pewkkrnmae lskdsasqgt gqgdpgpaag
     1141 hhaqplalqa teaeadkkkv leikdlccgh cfqelekakq ecqdlkgkle kccrhlqhle
     1201 rkhkavveki geennkvvee lieenndmkn kleelqtlck tpprslsaga ienaclpcsg
     1261 galeelrgqy ikavkkikcd mlryiqeske raaemvkaev lrerqetark mrkyyliclq
     1321 qilqddgkeg tapnfrdadc s
//
LOCUS       XP_047288210            1335 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 152 kDa isoform X9 [Homo sapiens].
ACCESSION   XP_047288210
VERSION     XP_047288210.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432254.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1335
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1335
                     /product="centrosomal protein of 152 kDa isoform X9"
                     /calculated_mol_wt=153906
     Region          <295..1045
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     CDS             1..1335
                     /gene="CEP152"
                     /gene_synonym="MCPH4; MCPH9; SCKL5"
                     /coded_by="XM_047432254.1:117..4124"
                     /db_xref="GeneID:22995"
                     /db_xref="HGNC:HGNC:29298"
                     /db_xref="MIM:613529"
ORIGIN      
        1 msldfgsval pvqnedeeyd eedyerekel qqlltdlphd mldddlsspe lqysdcsedg
       61 tdgqphhpeq lemswneqml pksqsvngyn eiqslyagek cgnvweenrs ktedrhpvyh
      121 peeggdeggs gysppskceq tdlyhlpenf rpytngqkqe fnnqatnvik fsdpqwnhfq
      181 gpscqglepy nkvtykpyqs saqnngspaq eitgsdtfeg lqqqflgane nsaenmqiiq
      241 lqvlnkaker qlenliekln eserqiryln hqlviikdek dgltlslres qklfqngker
      301 eiqleaqika letqiqalkv neeqmikksr ttemaleslk qqlvdlhhse slqrareqhe
      361 sivmgltkky eeqvlslqkn ldatvtalke qedicsrlkd hvkqlernqe aiklekteii
      421 nkltrslees qkqcahllqs gsvqevaqlq fqlqqaqkah amsanmnkal qeeltelkde
      481 islyesaakl gihpsdsege lnieltesyv dlgikkvnwk kskvtsivqe edpneelskd
      541 efilklkaev qrllgsnsmk rhlvsqlqnd lkdchkkied lhqvkkdeks ievetktdts
      601 ekpknqlwpe sstsdvvrdd illlkneiqv lqqqnqelke tegklrntnq dlcnqmrqmv
      661 qdfdhdkqea vdrcertyqq hheamktqir esllakhale kqqlfeayer thlqlrseld
      721 klnkevtavq ecylevcrek dnleltlrkt tekeqqtqek ikekliqqle kewqskldqt
      781 ikamkkktld cgsqtdqvtt sdviskkema imieeqkcti qqnleqekdi aikgamkkle
      841 ielelkhcen itkqveiavq nahqrwlgel pelaeyqalv kaeqkkweeq hevsvnkris
      901 favseakekw kselenmrkn ilpgkeleek ihslqkelel kneevpvvir aelakarsew
      961 nkekqeeihr iqeqneqdyr qflddhrnki nevlaaaked fmkqktelll qketelqtcl
     1021 dqsrrewtmq eakriqleiy qyeediltvl gvllsdtqke hisdsedkql leimstcssk
     1081 wmsvqyfekl kgciqkafqd tlpllvenad pewkkrnmae lskdsasqgt gqgdpgpaag
     1141 hhaqplalqa teaeaeennk vveelieenn dmknkleelq tlcktpprsl sagaienacl
     1201 pcsggaleel rgqyikavkk ikcdmlryiq eskeraaemv kaevlrerqe tarkmrkyyl
     1261 iclqqilqdd gkegaekkim naasklatma klletpisrd gillchpgwr avaqitatep
     1321 rlqllgsndp prsas
//
LOCUS       XP_011519683            1055 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 152 kDa isoform X10 [Homo sapiens].
ACCESSION   XP_011519683
VERSION     XP_011519683.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521381.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1055
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1055
                     /product="centrosomal protein of 152 kDa isoform X10"
                     /calculated_mol_wt=120231
     Region          <9..581
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     CDS             1..1055
                     /gene="CEP152"
                     /gene_synonym="MCPH4; MCPH9; SCKL5"
                     /coded_by="XM_011521381.3:1072..4239"
                     /db_xref="GeneID:22995"
                     /db_xref="HGNC:HGNC:29298"
                     /db_xref="MIM:613529"
ORIGIN      
        1 mrqmvqdfdh dkqeavdrce rtyqqhheam ktqireslla khalekqqlf eayerthlql
       61 rseldklnke vtavqecyle vcrekdnlel tlrkttekeq qtqekikekl iqqlekewqs
      121 kldqtikamk kktldcgsqt dqvttsdvis kkemaimiee qkctiqqnle qekdiaikga
      181 mkkleielel khcenitkqv eiavqnahqr wlgelpelae yqalvkaeqk kweeqhevsv
      241 nkrisfavse akekwksele nmrknilpgk eleekihslq kelelkneev pvviraelak
      301 arsewnkekq eeihriqeqn eqdyrqfldd hrnkinevla aakedfmkqk telllqkete
      361 lqtcldqsrr ewtmqeakri qleiyqyeed iltvlgvlls dtqkehisds edkqlleims
      421 tcsskwmsvq yfeklkgciq kafqdtlpll venadpewkk rnmaelskds asqgtgqgdp
      481 gpaaghhaqp lalqateaea dkkkvleikd lccghcfqel ekakqecqdl kgklekccrh
      541 lqhlerkhka vvekigeenn kvveelieen ndmknkleel qtlcktpprs lsagaienac
      601 lpcsggalee lrgqyikavk kikcdmlryi qeskeraaem vkaevlrerq etarkmrkyy
      661 liclqqilqd dgkegaekki mnaasklatm aklletpiss ksqskttqsa lpltsemlia
      721 vkkskrndvn qkipcciesk snsvntitrt lceqapkrra acnlqrllen sehqsikhvg
      781 skethlefqf gdgsckhlns lprnvspefv pcegeggfgl hkkkdllsdn gseslphsaa
      841 ypflgtlgnk psprctpgps esgcmhitfr dsnerlglkv ykcnplmese naaseksqgl
      901 dvqeppvkdg gdlsdclgwp sssatlsfds reasfvhgrp qgtleipses vkskqfspsg
      961 ylsdteesnm icqtmkcqry qtpylseett ylepgkisvn cghpsrhkad rlksdfkkls
     1021 stlpssvcqq psrklivpls sqqdsgfdsp fvnld
//
LOCUS       XP_016877504            1055 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 152 kDa isoform X10 [Homo sapiens].
ACCESSION   XP_016877504
VERSION     XP_016877504.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022015.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1055
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1055
                     /product="centrosomal protein of 152 kDa isoform X10"
                     /calculated_mol_wt=120231
     Region          <9..581
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     CDS             1..1055
                     /gene="CEP152"
                     /gene_synonym="MCPH4; MCPH9; SCKL5"
                     /coded_by="XM_017022015.2:254..3421"
                     /db_xref="GeneID:22995"
                     /db_xref="HGNC:HGNC:29298"
                     /db_xref="MIM:613529"
ORIGIN      
        1 mrqmvqdfdh dkqeavdrce rtyqqhheam ktqireslla khalekqqlf eayerthlql
       61 rseldklnke vtavqecyle vcrekdnlel tlrkttekeq qtqekikekl iqqlekewqs
      121 kldqtikamk kktldcgsqt dqvttsdvis kkemaimiee qkctiqqnle qekdiaikga
      181 mkkleielel khcenitkqv eiavqnahqr wlgelpelae yqalvkaeqk kweeqhevsv
      241 nkrisfavse akekwksele nmrknilpgk eleekihslq kelelkneev pvviraelak
      301 arsewnkekq eeihriqeqn eqdyrqfldd hrnkinevla aakedfmkqk telllqkete
      361 lqtcldqsrr ewtmqeakri qleiyqyeed iltvlgvlls dtqkehisds edkqlleims
      421 tcsskwmsvq yfeklkgciq kafqdtlpll venadpewkk rnmaelskds asqgtgqgdp
      481 gpaaghhaqp lalqateaea dkkkvleikd lccghcfqel ekakqecqdl kgklekccrh
      541 lqhlerkhka vvekigeenn kvveelieen ndmknkleel qtlcktpprs lsagaienac
      601 lpcsggalee lrgqyikavk kikcdmlryi qeskeraaem vkaevlrerq etarkmrkyy
      661 liclqqilqd dgkegaekki mnaasklatm aklletpiss ksqskttqsa lpltsemlia
      721 vkkskrndvn qkipcciesk snsvntitrt lceqapkrra acnlqrllen sehqsikhvg
      781 skethlefqf gdgsckhlns lprnvspefv pcegeggfgl hkkkdllsdn gseslphsaa
      841 ypflgtlgnk psprctpgps esgcmhitfr dsnerlglkv ykcnplmese naaseksqgl
      901 dvqeppvkdg gdlsdclgwp sssatlsfds reasfvhgrp qgtleipses vkskqfspsg
      961 ylsdteesnm icqtmkcqry qtpylseett ylepgkisvn cghpsrhkad rlksdfkkls
     1021 stlpssvcqq psrklivpls sqqdsgfdsp fvnld
//
LOCUS       XP_016877505             834 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 152 kDa isoform X11 [Homo sapiens].
ACCESSION   XP_016877505
VERSION     XP_016877505.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022016.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..834
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..834
                     /product="centrosomal protein of 152 kDa isoform X11"
                     /calculated_mol_wt=97032
     Region          <218..807
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..834
                     /gene="CEP152"
                     /gene_synonym="MCPH4; MCPH9; SCKL5"
                     /coded_by="XM_017022016.3:117..2621"
                     /db_xref="GeneID:22995"
                     /db_xref="HGNC:HGNC:29298"
                     /db_xref="MIM:613529"
ORIGIN      
        1 msldfgsval pvqnedeeyd eedyerekel qqlltdlphd mldddlsspe lqysdcsedg
       61 tdgqphhpeq lemswneqml pksqsvngyn eiqslyagek cgnvweenrs ktedrhpvyh
      121 peeggdeggs gysppskceq tdlyhlpenf rpytngqkqe fnnqatnvik fsdpqwnhfq
      181 gpscqglepy nkvtykpyqs saqnngspaq eitgsdtfeg lqqqflgane nsaenmqiiq
      241 lqvlnkaker qlenliekln eserqiryln hqlviikdek dgltlslres qklfqngker
      301 eiqleaqika letqiqalkv neeqmikksr ttemaleslk qqlvdlhhse slqrareqhe
      361 sivmgltkky eeqvlslqkn ldatvtalke qedicsrlkd hvkqlernqe aiklekteii
      421 nkltrslees qkqcahllqs gsvqevaqlq fqlqqaqkah amsanmnkal qeeltelkde
      481 islyesaakl gihpsdsege lnieltesyv dlgikkvnwk kskvtsivqe edpneelskd
      541 efilklkaev qrllgsnsmk rhlvsqlqnd lkdchkkied lhqvkkdeks ievetktdts
      601 ekpknqlwpe sstsdvvrdd illlkneiqv lqqqnqelke tegklrntnq dlcnqmrqmv
      661 qdfdhdkqea vdrcertyqq hheamktqir esllakhale kqqlfeayer thlqlrseld
      721 klnkevtavq ecylevcrek dnleltlrkt tekeqqtqek rqlleereey vsklqvelek
      781 kyqdtlmmek skwlkdqetd ikqqvesevi lakahwdkee qevwikisfw sphf
//
LOCUS       XP_047288212             460 aa            linear   PRI 05-AUG-2025
DEFINITION  golgin subfamily A member 8A isoform X1 [Homo sapiens].
ACCESSION   XP_047288212
VERSION     XP_047288212.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432256.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..460
                     /product="golgin subfamily A member 8A isoform X1"
                     /calculated_mol_wt=51263
     Region          75..>254
                     /region_name="GOLGA2L5"
                     /note="Putative golgin subfamily A member 2-like protein
                     5; pfam15070"
                     /db_xref="CDD:464485"
     Region          415..460
                     /region_name="GM130_C"
                     /note="GM130 C-terminal binding motif; pfam19046"
                     /db_xref="CDD:465957"
     CDS             1..460
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /coded_by="XM_047432256.1:2013..3395"
                     /db_xref="GeneID:23015"
                     /db_xref="HGNC:HGNC:31972"
                     /db_xref="MIM:616180"
ORIGIN      
        1 mkhslryfee eskdlagrlq rssqrigele wslcavaatq kkkpdgfssr skallkrqle
       61 qsireqillk ghvtqlkesl kevqlerdqy aeqikgeraq wqqrmrkmsq evctlkeekk
      121 hdthrveele rslsrlknqm aeplppdapa vssevelqdl rkelervage lqaqvennqc
      181 isllnrgqke rlreqeerlq eqqerlrere krlqqlaepq sdleelkhen ksalqleqqv
      241 kelqeklgqv metltsaeke peaavpasgt ggessglmdl leekadlreh veklelgfiq
      301 yrrerchqkv hrlltepgds akdaspgggh hqagpgqgge egeaagaagd gvaacgsyse
      361 ghgkflaaar npaaepspga papqelgaad khgdlceasl tnsvepaqge aregssqdnp
      421 taqpvvqllg emqdhqehpg lgsnccvpcf cwawlprrrr
//
LOCUS       XP_047288213             460 aa            linear   PRI 05-AUG-2025
DEFINITION  golgin subfamily A member 8A isoform X1 [Homo sapiens].
ACCESSION   XP_047288213
VERSION     XP_047288213.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432257.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..460
                     /product="golgin subfamily A member 8A isoform X1"
                     /calculated_mol_wt=51263
     Region          75..>254
                     /region_name="GOLGA2L5"
                     /note="Putative golgin subfamily A member 2-like protein
                     5; pfam15070"
                     /db_xref="CDD:464485"
     Region          415..460
                     /region_name="GM130_C"
                     /note="GM130 C-terminal binding motif; pfam19046"
                     /db_xref="CDD:465957"
     CDS             1..460
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /coded_by="XM_047432257.1:4563..5945"
                     /db_xref="GeneID:23015"
                     /db_xref="HGNC:HGNC:31972"
                     /db_xref="MIM:616180"
ORIGIN      
        1 mkhslryfee eskdlagrlq rssqrigele wslcavaatq kkkpdgfssr skallkrqle
       61 qsireqillk ghvtqlkesl kevqlerdqy aeqikgeraq wqqrmrkmsq evctlkeekk
      121 hdthrveele rslsrlknqm aeplppdapa vssevelqdl rkelervage lqaqvennqc
      181 isllnrgqke rlreqeerlq eqqerlrere krlqqlaepq sdleelkhen ksalqleqqv
      241 kelqeklgqv metltsaeke peaavpasgt ggessglmdl leekadlreh veklelgfiq
      301 yrrerchqkv hrlltepgds akdaspgggh hqagpgqgge egeaagaagd gvaacgsyse
      361 ghgkflaaar npaaepspga papqelgaad khgdlceasl tnsvepaqge aregssqdnp
      421 taqpvvqllg emqdhqehpg lgsnccvpcf cwawlprrrr
//
LOCUS       XP_047288214             460 aa            linear   PRI 05-AUG-2025
DEFINITION  golgin subfamily A member 8A isoform X1 [Homo sapiens].
ACCESSION   XP_047288214
VERSION     XP_047288214.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432258.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..460
                     /product="golgin subfamily A member 8A isoform X1"
                     /calculated_mol_wt=51263
     Region          75..>254
                     /region_name="GOLGA2L5"
                     /note="Putative golgin subfamily A member 2-like protein
                     5; pfam15070"
                     /db_xref="CDD:464485"
     Region          415..460
                     /region_name="GM130_C"
                     /note="GM130 C-terminal binding motif; pfam19046"
                     /db_xref="CDD:465957"
     CDS             1..460
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /coded_by="XM_047432258.1:2533..3915"
                     /db_xref="GeneID:23015"
                     /db_xref="HGNC:HGNC:31972"
                     /db_xref="MIM:616180"
ORIGIN      
        1 mkhslryfee eskdlagrlq rssqrigele wslcavaatq kkkpdgfssr skallkrqle
       61 qsireqillk ghvtqlkesl kevqlerdqy aeqikgeraq wqqrmrkmsq evctlkeekk
      121 hdthrveele rslsrlknqm aeplppdapa vssevelqdl rkelervage lqaqvennqc
      181 isllnrgqke rlreqeerlq eqqerlrere krlqqlaepq sdleelkhen ksalqleqqv
      241 kelqeklgqv metltsaeke peaavpasgt ggessglmdl leekadlreh veklelgfiq
      301 yrrerchqkv hrlltepgds akdaspgggh hqagpgqgge egeaagaagd gvaacgsyse
      361 ghgkflaaar npaaepspga papqelgaad khgdlceasl tnsvepaqge aregssqdnp
      421 taqpvvqllg emqdhqehpg lgsnccvpcf cwawlprrrr
//
LOCUS       XP_047288215             460 aa            linear   PRI 05-AUG-2025
DEFINITION  golgin subfamily A member 8A isoform X1 [Homo sapiens].
ACCESSION   XP_047288215
VERSION     XP_047288215.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432259.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..460
                     /product="golgin subfamily A member 8A isoform X1"
                     /calculated_mol_wt=51263
     Region          75..>254
                     /region_name="GOLGA2L5"
                     /note="Putative golgin subfamily A member 2-like protein
                     5; pfam15070"
                     /db_xref="CDD:464485"
     Region          415..460
                     /region_name="GM130_C"
                     /note="GM130 C-terminal binding motif; pfam19046"
                     /db_xref="CDD:465957"
     CDS             1..460
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /coded_by="XM_047432259.1:4009..5391"
                     /db_xref="GeneID:23015"
                     /db_xref="HGNC:HGNC:31972"
                     /db_xref="MIM:616180"
ORIGIN      
        1 mkhslryfee eskdlagrlq rssqrigele wslcavaatq kkkpdgfssr skallkrqle
       61 qsireqillk ghvtqlkesl kevqlerdqy aeqikgeraq wqqrmrkmsq evctlkeekk
      121 hdthrveele rslsrlknqm aeplppdapa vssevelqdl rkelervage lqaqvennqc
      181 isllnrgqke rlreqeerlq eqqerlrere krlqqlaepq sdleelkhen ksalqleqqv
      241 kelqeklgqv metltsaeke peaavpasgt ggessglmdl leekadlreh veklelgfiq
      301 yrrerchqkv hrlltepgds akdaspgggh hqagpgqgge egeaagaagd gvaacgsyse
      361 ghgkflaaar npaaepspga papqelgaad khgdlceasl tnsvepaqge aregssqdnp
      421 taqpvvqllg emqdhqehpg lgsnccvpcf cwawlprrrr
//
LOCUS       XP_047288216             460 aa            linear   PRI 05-AUG-2025
DEFINITION  golgin subfamily A member 8A isoform X1 [Homo sapiens].
ACCESSION   XP_047288216
VERSION     XP_047288216.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432260.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..460
                     /product="golgin subfamily A member 8A isoform X1"
                     /calculated_mol_wt=51263
     Region          75..>254
                     /region_name="GOLGA2L5"
                     /note="Putative golgin subfamily A member 2-like protein
                     5; pfam15070"
                     /db_xref="CDD:464485"
     Region          415..460
                     /region_name="GM130_C"
                     /note="GM130 C-terminal binding motif; pfam19046"
                     /db_xref="CDD:465957"
     CDS             1..460
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /coded_by="XM_047432260.1:4079..5461"
                     /db_xref="GeneID:23015"
                     /db_xref="HGNC:HGNC:31972"
                     /db_xref="MIM:616180"
ORIGIN      
        1 mkhslryfee eskdlagrlq rssqrigele wslcavaatq kkkpdgfssr skallkrqle
       61 qsireqillk ghvtqlkesl kevqlerdqy aeqikgeraq wqqrmrkmsq evctlkeekk
      121 hdthrveele rslsrlknqm aeplppdapa vssevelqdl rkelervage lqaqvennqc
      181 isllnrgqke rlreqeerlq eqqerlrere krlqqlaepq sdleelkhen ksalqleqqv
      241 kelqeklgqv metltsaeke peaavpasgt ggessglmdl leekadlreh veklelgfiq
      301 yrrerchqkv hrlltepgds akdaspgggh hqagpgqgge egeaagaagd gvaacgsyse
      361 ghgkflaaar npaaepspga papqelgaad khgdlceasl tnsvepaqge aregssqdnp
      421 taqpvvqllg emqdhqehpg lgsnccvpcf cwawlprrrr
//
LOCUS       XP_047288217             460 aa            linear   PRI 05-AUG-2025
DEFINITION  golgin subfamily A member 8A isoform X1 [Homo sapiens].
ACCESSION   XP_047288217
VERSION     XP_047288217.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432261.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..460
                     /product="golgin subfamily A member 8A isoform X1"
                     /calculated_mol_wt=51263
     Region          75..>254
                     /region_name="GOLGA2L5"
                     /note="Putative golgin subfamily A member 2-like protein
                     5; pfam15070"
                     /db_xref="CDD:464485"
     Region          415..460
                     /region_name="GM130_C"
                     /note="GM130 C-terminal binding motif; pfam19046"
                     /db_xref="CDD:465957"
     CDS             1..460
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /coded_by="XM_047432261.1:3739..5121"
                     /db_xref="GeneID:23015"
                     /db_xref="HGNC:HGNC:31972"
                     /db_xref="MIM:616180"
ORIGIN      
        1 mkhslryfee eskdlagrlq rssqrigele wslcavaatq kkkpdgfssr skallkrqle
       61 qsireqillk ghvtqlkesl kevqlerdqy aeqikgeraq wqqrmrkmsq evctlkeekk
      121 hdthrveele rslsrlknqm aeplppdapa vssevelqdl rkelervage lqaqvennqc
      181 isllnrgqke rlreqeerlq eqqerlrere krlqqlaepq sdleelkhen ksalqleqqv
      241 kelqeklgqv metltsaeke peaavpasgt ggessglmdl leekadlreh veklelgfiq
      301 yrrerchqkv hrlltepgds akdaspgggh hqagpgqgge egeaagaagd gvaacgsyse
      361 ghgkflaaar npaaepspga papqelgaad khgdlceasl tnsvepaqge aregssqdnp
      421 taqpvvqllg emqdhqehpg lgsnccvpcf cwawlprrrr
//
LOCUS       XP_047288218             360 aa            linear   PRI 05-AUG-2025
DEFINITION  golgin subfamily A member 8A isoform X2 [Homo sapiens].
ACCESSION   XP_047288218
VERSION     XP_047288218.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432262.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..360
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..360
                     /product="golgin subfamily A member 8A isoform X2"
                     /calculated_mol_wt=41061
     Region          75..>254
                     /region_name="GOLGA2L5"
                     /note="Putative golgin subfamily A member 2-like protein
                     5; pfam15070"
                     /db_xref="CDD:464485"
     CDS             1..360
                     /gene="GOLGA8A"
                     /gene_synonym="CFAP286; FAP286; GM88; GOLGA8B"
                     /coded_by="XM_047432262.1:3936..5018"
                     /db_xref="GeneID:23015"
                     /db_xref="HGNC:HGNC:31972"
                     /db_xref="MIM:616180"
ORIGIN      
        1 mkhslryfee eskdlagrlq rssqrigele wslcavaatq kkkpdgfssr skallkrqle
       61 qsireqillk ghvtqlkesl kevqlerdqy aeqikgeraq wqqrmrkmsq evctlkeekk
      121 hdthrveele rslsrlknqm aeplppdapa vssevelqdl rkelervage lqaqvennqc
      181 isllnrgqke rlreqeerlq eqqerlrere krlqqlaepq sdleelkhen ksalqleqqv
      241 kelqeklgqv metltsaeke peaavpasgt ggesvsgetl ralqevmekl egkrpygppg
      301 geggpegacg etgtwihpvp erempsests psnrargqcq rcvtgrrpss gwprtrrrgr
//
LOCUS       XP_016877510            1411 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 609 isoform X1 [Homo sapiens].
ACCESSION   XP_016877510
VERSION     XP_016877510.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022021.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1411
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1411
                     /product="zinc finger protein 609 isoform X1"
                     /calculated_mol_wt=151061
     Region          <412..533
                     /region_name="SFP1"
                     /note="Putative transcriptional repressor regulating G2/M
                     transition [Transcription / Cell division and chromosome
                     partitioning]; COG5189"
                     /db_xref="CDD:227516"
     CDS             1..1411
                     /gene="ZNF609"
                     /coded_by="XM_017022021.2:286..4521"
                     /db_xref="GeneID:23060"
                     /db_xref="HGNC:HGNC:29003"
                     /db_xref="MIM:617474"
ORIGIN      
        1 mslssgasgg kgvdanpvet ydsgdewdig vgnliidlda dlekdqqkle msgskevgip
       61 apnavatlpd nikfvtpvpg pqgkegksks krsksgkdts kptpgtslft psegaaskke
      121 vqgrsgdgan agglvaaiap kgsekaakas rsvagskkek enssskskke rsegvgtcse
      181 kdpgvlqpvp lggrggqydg sagvdtgave plgsiaiepg aalnplgtkp epeegenecr
      241 llkkvksekm espvstpavl pihllvpvvn ndisspceqi mvrtrsvgvn tcdvalatep
      301 eclgpcepgt svnlegivwq etedgmlvvn vtwrnktyvg tlldctrhdw apprfcdspt
      361 sdlemrngrg rgkrmrpnsn tpvnetatas dskgtsnssk traganskgr rgsqnssehr
      421 ppasstsedv kaspssankr knkplsdmel nsssedskgs krvrtnsmgs atgplpgtkv
      481 eptvldrncp spvlidcphp ncnkkykhin glkyhqahah tdddskpead gdseygeepi
      541 lhadlgscng asvsqkgsls parsatpkvr lvephspsps skfstkglck kklsgegdtd
      601 lgalsndgsd dgpsvmdets ndafdslerk cmekekckkp sslkpekips kslksarpia
      661 paippqqiyt fqtatftaas pgsssgltat vaqampnspq lkpiqpkptv mgepftvnpa
      721 ltpakdkkkk dkkkkesske lespltpgkv craeegkspf ressgdgmkm egllngssdp
      781 hqsrlasika eadkiysftd napspsiggs srlenttptq pltplhvvtq ngaeassvkt
      841 nspaysdisd agedgegkvd svkskdaeql vkegakktlf ppqpqskdsp yyqgfesyys
      901 psyaqsspga lnpssqagve sqalktkrde epesiegkvk ndiceekkpe lssssqqpsv
      961 iqqrpnmymq slyynqyayv ppygysdqsy hthllstnta yrqqyeeqqk rqsleqqqrg
     1021 vdkkaemglk ereaalkeew kqkpsipptl tkapsltdlv ksgpgkakep gadpaksvii
     1081 pklddssklp gqapeglkvk lsdashlske aseaktgaec grqaemdpil wyrqeaeprm
     1141 wtyvypakys diksederwk eerdrklkee rsrskdsvpk edgkestssd cklptseesr
     1201 lgskeprpsv hvpvsspltq hqsyipymhg ysysqsydpn hpsyrsmpav mmqnypgsyl
     1261 pssysfspyg skvsggedad karaspsvtc kssseskald ilqqhashyk sksptisdkt
     1321 sqerdrggcg vvggggscss vggasggers vdrprtspsq rlmsthhhhh hlgysllpaq
     1381 ynlpyaagls staivasqqg stpslypppr r
//
LOCUS       XP_047288219            1411 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 609 isoform X1 [Homo sapiens].
ACCESSION   XP_047288219
VERSION     XP_047288219.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432263.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1411
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1411
                     /product="zinc finger protein 609 isoform X1"
                     /calculated_mol_wt=151061
     Region          <412..533
                     /region_name="SFP1"
                     /note="Putative transcriptional repressor regulating G2/M
                     transition [Transcription / Cell division and chromosome
                     partitioning]; COG5189"
                     /db_xref="CDD:227516"
     CDS             1..1411
                     /gene="ZNF609"
                     /coded_by="XM_047432263.1:177..4412"
                     /db_xref="GeneID:23060"
                     /db_xref="HGNC:HGNC:29003"
                     /db_xref="MIM:617474"
ORIGIN      
        1 mslssgasgg kgvdanpvet ydsgdewdig vgnliidlda dlekdqqkle msgskevgip
       61 apnavatlpd nikfvtpvpg pqgkegksks krsksgkdts kptpgtslft psegaaskke
      121 vqgrsgdgan agglvaaiap kgsekaakas rsvagskkek enssskskke rsegvgtcse
      181 kdpgvlqpvp lggrggqydg sagvdtgave plgsiaiepg aalnplgtkp epeegenecr
      241 llkkvksekm espvstpavl pihllvpvvn ndisspceqi mvrtrsvgvn tcdvalatep
      301 eclgpcepgt svnlegivwq etedgmlvvn vtwrnktyvg tlldctrhdw apprfcdspt
      361 sdlemrngrg rgkrmrpnsn tpvnetatas dskgtsnssk traganskgr rgsqnssehr
      421 ppasstsedv kaspssankr knkplsdmel nsssedskgs krvrtnsmgs atgplpgtkv
      481 eptvldrncp spvlidcphp ncnkkykhin glkyhqahah tdddskpead gdseygeepi
      541 lhadlgscng asvsqkgsls parsatpkvr lvephspsps skfstkglck kklsgegdtd
      601 lgalsndgsd dgpsvmdets ndafdslerk cmekekckkp sslkpekips kslksarpia
      661 paippqqiyt fqtatftaas pgsssgltat vaqampnspq lkpiqpkptv mgepftvnpa
      721 ltpakdkkkk dkkkkesske lespltpgkv craeegkspf ressgdgmkm egllngssdp
      781 hqsrlasika eadkiysftd napspsiggs srlenttptq pltplhvvtq ngaeassvkt
      841 nspaysdisd agedgegkvd svkskdaeql vkegakktlf ppqpqskdsp yyqgfesyys
      901 psyaqsspga lnpssqagve sqalktkrde epesiegkvk ndiceekkpe lssssqqpsv
      961 iqqrpnmymq slyynqyayv ppygysdqsy hthllstnta yrqqyeeqqk rqsleqqqrg
     1021 vdkkaemglk ereaalkeew kqkpsipptl tkapsltdlv ksgpgkakep gadpaksvii
     1081 pklddssklp gqapeglkvk lsdashlske aseaktgaec grqaemdpil wyrqeaeprm
     1141 wtyvypakys diksederwk eerdrklkee rsrskdsvpk edgkestssd cklptseesr
     1201 lgskeprpsv hvpvsspltq hqsyipymhg ysysqsydpn hpsyrsmpav mmqnypgsyl
     1261 pssysfspyg skvsggedad karaspsvtc kssseskald ilqqhashyk sksptisdkt
     1321 sqerdrggcg vvggggscss vggasggers vdrprtspsq rlmsthhhhh hlgysllpaq
     1381 ynlpyaagls staivasqqg stpslypppr r
//
LOCUS       XP_047288221            1411 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 609 isoform X1 [Homo sapiens].
ACCESSION   XP_047288221
VERSION     XP_047288221.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432265.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1411
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1411
                     /product="zinc finger protein 609 isoform X1"
                     /calculated_mol_wt=151061
     Region          <412..533
                     /region_name="SFP1"
                     /note="Putative transcriptional repressor regulating G2/M
                     transition [Transcription / Cell division and chromosome
                     partitioning]; COG5189"
                     /db_xref="CDD:227516"
     CDS             1..1411
                     /gene="ZNF609"
                     /coded_by="XM_047432265.1:247..4482"
                     /db_xref="GeneID:23060"
                     /db_xref="HGNC:HGNC:29003"
                     /db_xref="MIM:617474"
ORIGIN      
        1 mslssgasgg kgvdanpvet ydsgdewdig vgnliidlda dlekdqqkle msgskevgip
       61 apnavatlpd nikfvtpvpg pqgkegksks krsksgkdts kptpgtslft psegaaskke
      121 vqgrsgdgan agglvaaiap kgsekaakas rsvagskkek enssskskke rsegvgtcse
      181 kdpgvlqpvp lggrggqydg sagvdtgave plgsiaiepg aalnplgtkp epeegenecr
      241 llkkvksekm espvstpavl pihllvpvvn ndisspceqi mvrtrsvgvn tcdvalatep
      301 eclgpcepgt svnlegivwq etedgmlvvn vtwrnktyvg tlldctrhdw apprfcdspt
      361 sdlemrngrg rgkrmrpnsn tpvnetatas dskgtsnssk traganskgr rgsqnssehr
      421 ppasstsedv kaspssankr knkplsdmel nsssedskgs krvrtnsmgs atgplpgtkv
      481 eptvldrncp spvlidcphp ncnkkykhin glkyhqahah tdddskpead gdseygeepi
      541 lhadlgscng asvsqkgsls parsatpkvr lvephspsps skfstkglck kklsgegdtd
      601 lgalsndgsd dgpsvmdets ndafdslerk cmekekckkp sslkpekips kslksarpia
      661 paippqqiyt fqtatftaas pgsssgltat vaqampnspq lkpiqpkptv mgepftvnpa
      721 ltpakdkkkk dkkkkesske lespltpgkv craeegkspf ressgdgmkm egllngssdp
      781 hqsrlasika eadkiysftd napspsiggs srlenttptq pltplhvvtq ngaeassvkt
      841 nspaysdisd agedgegkvd svkskdaeql vkegakktlf ppqpqskdsp yyqgfesyys
      901 psyaqsspga lnpssqagve sqalktkrde epesiegkvk ndiceekkpe lssssqqpsv
      961 iqqrpnmymq slyynqyayv ppygysdqsy hthllstnta yrqqyeeqqk rqsleqqqrg
     1021 vdkkaemglk ereaalkeew kqkpsipptl tkapsltdlv ksgpgkakep gadpaksvii
     1081 pklddssklp gqapeglkvk lsdashlske aseaktgaec grqaemdpil wyrqeaeprm
     1141 wtyvypakys diksederwk eerdrklkee rsrskdsvpk edgkestssd cklptseesr
     1201 lgskeprpsv hvpvsspltq hqsyipymhg ysysqsydpn hpsyrsmpav mmqnypgsyl
     1261 pssysfspyg skvsggedad karaspsvtc kssseskald ilqqhashyk sksptisdkt
     1321 sqerdrggcg vvggggscss vggasggers vdrprtspsq rlmsthhhhh hlgysllpaq
     1381 ynlpyaagls staivasqqg stpslypppr r
//
LOCUS       XP_047288222            1411 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 609 isoform X1 [Homo sapiens].
ACCESSION   XP_047288222
VERSION     XP_047288222.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432266.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1411
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1411
                     /product="zinc finger protein 609 isoform X1"
                     /calculated_mol_wt=151061
     Region          <412..533
                     /region_name="SFP1"
                     /note="Putative transcriptional repressor regulating G2/M
                     transition [Transcription / Cell division and chromosome
                     partitioning]; COG5189"
                     /db_xref="CDD:227516"
     CDS             1..1411
                     /gene="ZNF609"
                     /coded_by="XM_047432266.1:272..4507"
                     /db_xref="GeneID:23060"
                     /db_xref="HGNC:HGNC:29003"
                     /db_xref="MIM:617474"
ORIGIN      
        1 mslssgasgg kgvdanpvet ydsgdewdig vgnliidlda dlekdqqkle msgskevgip
       61 apnavatlpd nikfvtpvpg pqgkegksks krsksgkdts kptpgtslft psegaaskke
      121 vqgrsgdgan agglvaaiap kgsekaakas rsvagskkek enssskskke rsegvgtcse
      181 kdpgvlqpvp lggrggqydg sagvdtgave plgsiaiepg aalnplgtkp epeegenecr
      241 llkkvksekm espvstpavl pihllvpvvn ndisspceqi mvrtrsvgvn tcdvalatep
      301 eclgpcepgt svnlegivwq etedgmlvvn vtwrnktyvg tlldctrhdw apprfcdspt
      361 sdlemrngrg rgkrmrpnsn tpvnetatas dskgtsnssk traganskgr rgsqnssehr
      421 ppasstsedv kaspssankr knkplsdmel nsssedskgs krvrtnsmgs atgplpgtkv
      481 eptvldrncp spvlidcphp ncnkkykhin glkyhqahah tdddskpead gdseygeepi
      541 lhadlgscng asvsqkgsls parsatpkvr lvephspsps skfstkglck kklsgegdtd
      601 lgalsndgsd dgpsvmdets ndafdslerk cmekekckkp sslkpekips kslksarpia
      661 paippqqiyt fqtatftaas pgsssgltat vaqampnspq lkpiqpkptv mgepftvnpa
      721 ltpakdkkkk dkkkkesske lespltpgkv craeegkspf ressgdgmkm egllngssdp
      781 hqsrlasika eadkiysftd napspsiggs srlenttptq pltplhvvtq ngaeassvkt
      841 nspaysdisd agedgegkvd svkskdaeql vkegakktlf ppqpqskdsp yyqgfesyys
      901 psyaqsspga lnpssqagve sqalktkrde epesiegkvk ndiceekkpe lssssqqpsv
      961 iqqrpnmymq slyynqyayv ppygysdqsy hthllstnta yrqqyeeqqk rqsleqqqrg
     1021 vdkkaemglk ereaalkeew kqkpsipptl tkapsltdlv ksgpgkakep gadpaksvii
     1081 pklddssklp gqapeglkvk lsdashlske aseaktgaec grqaemdpil wyrqeaeprm
     1141 wtyvypakys diksederwk eerdrklkee rsrskdsvpk edgkestssd cklptseesr
     1201 lgskeprpsv hvpvsspltq hqsyipymhg ysysqsydpn hpsyrsmpav mmqnypgsyl
     1261 pssysfspyg skvsggedad karaspsvtc kssseskald ilqqhashyk sksptisdkt
     1321 sqerdrggcg vvggggscss vggasggers vdrprtspsq rlmsthhhhh hlgysllpaq
     1381 ynlpyaagls staivasqqg stpslypppr r
//
LOCUS       XP_011519689             926 aa            linear   PRI 05-AUG-2025
DEFINITION  TBC1 domain family member 2B isoform X1 [Homo sapiens].
ACCESSION   XP_011519689
VERSION     XP_011519689.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521387.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..926
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..926
                     /product="TBC1 domain family member 2B isoform X1"
                     /calculated_mol_wt=105305
     Region          36..144
                     /region_name="PH_TBC1D2A"
                     /note="TBC1 domain family member 2A pleckstrin homology
                     (PH) domain; cd01265"
                     /db_xref="CDD:269966"
     Region          <338..>610
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          670..839
                     /region_name="RabGAP-TBC"
                     /note="Rab-GTPase-TBC domain; pfam00566"
                     /db_xref="CDD:459855"
     CDS             1..926
                     /gene="TBC1D2B"
                     /gene_synonym="NEDSGO"
                     /coded_by="XM_011521387.3:60..2840"
                     /db_xref="GeneID:23102"
                     /db_xref="HGNC:HGNC:29183"
                     /db_xref="MIM:619152"
ORIGIN      
        1 mpgagaraee gggggegaaq gaaaepgagp areparlcgy lqklsgkgpl rgyrsrwfvf
       61 darrcylyyf kspqdalplg hldiadacfs yqgpdeaaep gteppahfqv hsagavtvlk
      121 apnrqlmtyw lqelqqkrwe ycnsldmvkw dsrtsptpgd fpkglvardn tdliyphpna
      181 saekarnvla vetvpgelvg eqaanqpapg hpnsinfysl kqwgnelkns mssfrpgrgh
      241 ndsrrtvfyt neewelldpt pkdleesivq eekkkltpeg nkgvtgsgfp fdfgrnpykg
      301 krplkdiigs yknrhssgdp ssegtsgsgs vsirkpasem qlqvqsqqee leqlkkdlss
      361 qkelvrllqq tvrssqydky ftssrlcegv pkdtlellhq kddqilglts qlerfsleke
      421 slqqevrtlk skvgelneql gmlmetiqak deviiklseg egngppptva psspsvvpva
      481 rdqleldrlk yssleaklcq ieskylillq emktpvcsed qgptreviaq lledalqves
      541 qeqpeqafvk phlvseydiy gfrtvpedde eeklvakvra ldlktlylte nqevstgvkw
      601 enyfastvnr emmcspelkn liragipheh rskvwkwcvd rhtrkfkdnt epghfqtllq
      661 kalekqnpas kqieldllrt lpnnkhyscp tsegiqklrn vllafswrnp digycqglnr
      721 lvavallyle qedafwclvt ivevfmprdy ytktllgsqv dqrvfrdlms eklprlhghf
      781 eqykvdytli tfnwflvvfv dsvvsdilfk iwdsflyegp kvifrfalal fkykeeeilk
      841 lqdsmsifky lryftrtild arklisisfg dlnpfplrqi rnrrayhlek vrleltelea
      901 iredflrerd tspdkgelvs deeedt
//
LOCUS       XP_047288223             911 aa            linear   PRI 05-AUG-2025
DEFINITION  TBC1 domain family member 2B isoform X2 [Homo sapiens].
ACCESSION   XP_047288223
VERSION     XP_047288223.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432267.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..911
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..911
                     /product="TBC1 domain family member 2B isoform X2"
                     /calculated_mol_wt=103571
     Region          36..144
                     /region_name="PH_TBC1D2A"
                     /note="TBC1 domain family member 2A pleckstrin homology
                     (PH) domain; cd01265"
                     /db_xref="CDD:269966"
     Region          342..>647
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          707..876
                     /region_name="RabGAP-TBC"
                     /note="Rab-GTPase-TBC domain; pfam00566"
                     /db_xref="CDD:459855"
     CDS             1..911
                     /gene="TBC1D2B"
                     /gene_synonym="NEDSGO"
                     /coded_by="XM_047432267.1:60..2795"
                     /db_xref="GeneID:23102"
                     /db_xref="HGNC:HGNC:29183"
                     /db_xref="MIM:619152"
ORIGIN      
        1 mpgagaraee gggggegaaq gaaaepgagp areparlcgy lqklsgkgpl rgyrsrwfvf
       61 darrcylyyf kspqdalplg hldiadacfs yqgpdeaaep gteppahfqv hsagavtvlk
      121 apnrqlmtyw lqelqqkrwe ycnsldmvkw dsrtsptpgd fpkglvardn tdliyphpna
      181 saekarnvla vetvpgelvg eqaanqpapg hpnsinfysl kqwgnelkns mssfrpgrgh
      241 ndsrrtvfyt neewelldpt pkdleesivq eekkkltpeg nkgvtgsgfp fdfgrnpykg
      301 krplkdiigs yknrhssgdp ssegtsgsgs vsirkpasem qlqvqsqqee leqlkkdlss
      361 qkelvrllqq tvrssqydky ftssrlcegv pkdtlellhq kddqilglts qlerfsleke
      421 slqqevrtlk skvgelneql gmlmetiqak deviiklseg egngppptva psspsvvpva
      481 rdqleldrlk dnlqgyktqn kflnkeilel salrrnaerr erdlmakyss leaklcqies
      541 kylillqemk tpvcsedqgp treviaqlle dalqvesqeq peqafvkphl vseydiygfr
      601 tvpeddeeek lvakvraldl ktlyltenqe vstgvkweny fastvnremm cspelknlir
      661 agiphehrsk vwkwcvdrht rkfkdntepg hfqtllqkal ekqnpaskqi eldllrtlpn
      721 nkhyscptse giqklrnvll afswrnpdig ycqglnrlva vallyleqed afwclvtive
      781 vfmprdyytk tllgsqvdqr vfrdlmsekl prlhghfeqy kvdytlitfn wflvvfvdsv
      841 vsdilfkiwd sflyegpkvi frfalalfky keeeilklqd smsifkylry ftrtildarl
      901 hldtchianw v
//
LOCUS       XP_047288224             766 aa            linear   PRI 05-AUG-2025
DEFINITION  TBC1 domain family member 2B isoform X3 [Homo sapiens].
ACCESSION   XP_047288224
VERSION     XP_047288224.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432268.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..766
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..766
                     /product="TBC1 domain family member 2B isoform X3"
                     /calculated_mol_wt=86040
     Region          36..144
                     /region_name="PH_TBC1D2A"
                     /note="TBC1 domain family member 2A pleckstrin homology
                     (PH) domain; cd01265"
                     /db_xref="CDD:269966"
     Region          342..>647
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          659..>756
                     /region_name="TBC"
                     /note="Domain in Tre-2, BUB2p, and Cdc16p. Probable
                     Rab-GAPs; smart00164"
                     /db_xref="CDD:214540"
     CDS             1..766
                     /gene="TBC1D2B"
                     /gene_synonym="NEDSGO"
                     /coded_by="XM_047432268.1:60..2360"
                     /db_xref="GeneID:23102"
                     /db_xref="HGNC:HGNC:29183"
                     /db_xref="MIM:619152"
ORIGIN      
        1 mpgagaraee gggggegaaq gaaaepgagp areparlcgy lqklsgkgpl rgyrsrwfvf
       61 darrcylyyf kspqdalplg hldiadacfs yqgpdeaaep gteppahfqv hsagavtvlk
      121 apnrqlmtyw lqelqqkrwe ycnsldmvkw dsrtsptpgd fpkglvardn tdliyphpna
      181 saekarnvla vetvpgelvg eqaanqpapg hpnsinfysl kqwgnelkns mssfrpgrgh
      241 ndsrrtvfyt neewelldpt pkdleesivq eekkkltpeg nkgvtgsgfp fdfgrnpykg
      301 krplkdiigs yknrhssgdp ssegtsgsgs vsirkpasem qlqvqsqqee leqlkkdlss
      361 qkelvrllqq tvrssqydky ftssrlcegv pkdtlellhq kddqilglts qlerfsleke
      421 slqqevrtlk skvgelneql gmlmetiqak deviiklseg egngppptva psspsvvpva
      481 rdqleldrlk dnlqgyktqn kflnkeilel salrrnaerr erdlmakyss leaklcqies
      541 kylillqemk tpvcsedqgp treviaqlle dalqvesqeq peqafvkphl vseydiygfr
      601 tvpeddeeek lvakvraldl ktlyltenqe vstgvkweny fastvnremm cspelknlir
      661 agiphehrsk vwkwcvdrht rkfkdntepg hfqtllqkal ekqnpaskqi eldllrtlpn
      721 nkhyscptse giqklrnvll afswrnpdig ycqglnrwts gcsetl
//
LOCUS       XP_047288225             733 aa            linear   PRI 05-AUG-2025
DEFINITION  TBC1 domain family member 2B isoform X4 [Homo sapiens].
ACCESSION   XP_047288225
VERSION     XP_047288225.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432269.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..733
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..733
                     /product="TBC1 domain family member 2B isoform X4"
                     /calculated_mol_wt=84826
     Region          113..>321
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     Region          477..646
                     /region_name="RabGAP-TBC"
                     /note="Rab-GTPase-TBC domain; pfam00566"
                     /db_xref="CDD:459855"
     CDS             1..733
                     /gene="TBC1D2B"
                     /gene_synonym="NEDSGO"
                     /coded_by="XM_047432269.1:596..2797"
                     /db_xref="GeneID:23102"
                     /db_xref="HGNC:HGNC:29183"
                     /db_xref="MIM:619152"
ORIGIN      
        1 mssfrpgrgh ndsrrtvfyt neewelldpt pkdleesivq eekkkltpeg nkgvtgsgfp
       61 fdfgrnpykg krplkdiigs yknrhssgdp ssegtsgsgs vsirkpasem qlqvqsqqee
      121 leqlkkdlss qkelvrllqq tvrssqydky ftssrlcegv pkdtlellhq kddqilglts
      181 qlerfsleke slqqevrtlk skvgelneql gmlmetiqak deviiklseg egngppptva
      241 psspsvvpva rdqleldrlk dnlqgyktqn kflnkeilel salrrnaerr erdlmakyss
      301 leaklcqies kylillqemk tpvcsedqgp treviaqlle dalqvesqeq peqafvkphl
      361 vseydiygfr tvpeddeeek lvakvraldl ktlyltenqe vstgvkweny fastvnremm
      421 cspelknlir agiphehrsk vwkwcvdrht rkfkdntepg hfqtllqkal ekqnpaskqi
      481 eldllrtlpn nkhyscptse giqklrnvll afswrnpdig ycqglnrlva vallyleqed
      541 afwclvtive vfmprdyytk tllgsqvdqr vfrdlmsekl prlhghfeqy kvdytlitfn
      601 wflvvfvdsv vsdilfkiwd sflyegpkvi frfalalfky keeeilklqd smsifkylry
      661 ftrtildark lisisfgdln pfplrqirnr rayhlekvrl elteleaire dflrerdtsp
      721 dkgelvsdee edt
//
LOCUS       XP_047288226             733 aa            linear   PRI 05-AUG-2025
DEFINITION  TBC1 domain family member 2B isoform X4 [Homo sapiens].
ACCESSION   XP_047288226
VERSION     XP_047288226.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432270.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..733
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..733
                     /product="TBC1 domain family member 2B isoform X4"
                     /calculated_mol_wt=84826
     Region          113..>321
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     Region          477..646
                     /region_name="RabGAP-TBC"
                     /note="Rab-GTPase-TBC domain; pfam00566"
                     /db_xref="CDD:459855"
     CDS             1..733
                     /gene="TBC1D2B"
                     /gene_synonym="NEDSGO"
                     /coded_by="XM_047432270.1:156..2357"
                     /db_xref="GeneID:23102"
                     /db_xref="HGNC:HGNC:29183"
                     /db_xref="MIM:619152"
ORIGIN      
        1 mssfrpgrgh ndsrrtvfyt neewelldpt pkdleesivq eekkkltpeg nkgvtgsgfp
       61 fdfgrnpykg krplkdiigs yknrhssgdp ssegtsgsgs vsirkpasem qlqvqsqqee
      121 leqlkkdlss qkelvrllqq tvrssqydky ftssrlcegv pkdtlellhq kddqilglts
      181 qlerfsleke slqqevrtlk skvgelneql gmlmetiqak deviiklseg egngppptva
      241 psspsvvpva rdqleldrlk dnlqgyktqn kflnkeilel salrrnaerr erdlmakyss
      301 leaklcqies kylillqemk tpvcsedqgp treviaqlle dalqvesqeq peqafvkphl
      361 vseydiygfr tvpeddeeek lvakvraldl ktlyltenqe vstgvkweny fastvnremm
      421 cspelknlir agiphehrsk vwkwcvdrht rkfkdntepg hfqtllqkal ekqnpaskqi
      481 eldllrtlpn nkhyscptse giqklrnvll afswrnpdig ycqglnrlva vallyleqed
      541 afwclvtive vfmprdyytk tllgsqvdqr vfrdlmsekl prlhghfeqy kvdytlitfn
      601 wflvvfvdsv vsdilfkiwd sflyegpkvi frfalalfky keeeilklqd smsifkylry
      661 ftrtildark lisisfgdln pfplrqirnr rayhlekvrl elteleaire dflrerdtsp
      721 dkgelvsdee edt
//
LOCUS       XP_047288227             733 aa            linear   PRI 05-AUG-2025
DEFINITION  TBC1 domain family member 2B isoform X4 [Homo sapiens].
ACCESSION   XP_047288227
VERSION     XP_047288227.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432271.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..733
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..733
                     /product="TBC1 domain family member 2B isoform X4"
                     /calculated_mol_wt=84826
     Region          113..>321
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     Region          477..646
                     /region_name="RabGAP-TBC"
                     /note="Rab-GTPase-TBC domain; pfam00566"
                     /db_xref="CDD:459855"
     CDS             1..733
                     /gene="TBC1D2B"
                     /gene_synonym="NEDSGO"
                     /coded_by="XM_047432271.1:130..2331"
                     /db_xref="GeneID:23102"
                     /db_xref="HGNC:HGNC:29183"
                     /db_xref="MIM:619152"
ORIGIN      
        1 mssfrpgrgh ndsrrtvfyt neewelldpt pkdleesivq eekkkltpeg nkgvtgsgfp
       61 fdfgrnpykg krplkdiigs yknrhssgdp ssegtsgsgs vsirkpasem qlqvqsqqee
      121 leqlkkdlss qkelvrllqq tvrssqydky ftssrlcegv pkdtlellhq kddqilglts
      181 qlerfsleke slqqevrtlk skvgelneql gmlmetiqak deviiklseg egngppptva
      241 psspsvvpva rdqleldrlk dnlqgyktqn kflnkeilel salrrnaerr erdlmakyss
      301 leaklcqies kylillqemk tpvcsedqgp treviaqlle dalqvesqeq peqafvkphl
      361 vseydiygfr tvpeddeeek lvakvraldl ktlyltenqe vstgvkweny fastvnremm
      421 cspelknlir agiphehrsk vwkwcvdrht rkfkdntepg hfqtllqkal ekqnpaskqi
      481 eldllrtlpn nkhyscptse giqklrnvll afswrnpdig ycqglnrlva vallyleqed
      541 afwclvtive vfmprdyytk tllgsqvdqr vfrdlmsekl prlhghfeqy kvdytlitfn
      601 wflvvfvdsv vsdilfkiwd sflyegpkvi frfalalfky keeeilklqd smsifkylry
      661 ftrtildark lisisfgdln pfplrqirnr rayhlekvrl elteleaire dflrerdtsp
      721 dkgelvsdee edt
//
LOCUS       XP_016877514             748 aa            linear   PRI 05-AUG-2025
DEFINITION  long-chain-fatty-acid--CoA ligase ACSBG1 isoform X1 [Homo sapiens].
ACCESSION   XP_016877514
VERSION     XP_016877514.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022025.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..748
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..748
                     /product="long-chain-fatty-acid--CoA ligase ACSBG1 isoform
                     X1"
                     /calculated_mol_wt=83530
     Region          125..713
                     /region_name="ACSBG_like"
                     /note="Bubblegum-like very long-chain fatty acid CoA
                     synthetase (VL-FACS); cd05933"
                     /db_xref="CDD:341256"
     Site            order(279,282..287,289..290)
                     /site_type="other"
                     /note="acyl-activating enzyme (AAE) consensus motif"
                     /db_xref="CDD:341256"
     Site            order(282,404..405,472..477,550,562,565,577,699)
                     /site_type="other"
                     /note="putative AMP binding site [chemical binding]"
                     /db_xref="CDD:341256"
     Site            order(282,326..327,375,377..378,381,404..405,472..477,550,
                     562,565,574..577,676)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:341256"
     Site            order(326,377..378,381,404,574..576,670,676)
                     /site_type="other"
                     /note="putative CoA binding site [chemical binding]"
                     /db_xref="CDD:341256"
     CDS             1..748
                     /gene="ACSBG1"
                     /gene_synonym="BG; BG1; BGM; GR-LACS; LPD"
                     /coded_by="XM_017022025.3:65..2311"
                     /db_xref="GeneID:23205"
                     /db_xref="HGNC:HGNC:29567"
                     /db_xref="MIM:614362"
ORIGIN      
        1 mprnsgagyg cphgdpsmld sretpqesrq dmivrttqek lktssltdrq plskeslnha
       61 lelsvpekvn naqwdapeea lwttradgrv rlridpscpq lpytvhrmfy ealdkygdli
      121 algfkrqdkw ehisysqyyl larraakgfl klglkqahsv ailgfnspew ffsavgtvfa
      181 ggivtgiytt sspeacqyia ydccanvimv dtqkqlekil kiwkqlphlk avviykeppp
      241 nkmanvytme efmelgnevp eealdaiidt qqpnqccvlv ytsgttgnpk gvmlsqdnit
      301 wtarygsqag dirpaevqqe vvvsylplsh iaaqiydlwt giqwgaqvcf aepdalkgsl
      361 vntlrevept shmgvprvwe kimeriqeva aqsgfirrkm llwamsvtle qnltcpgsdl
      421 kpfttrlady lvlakvrqal gfakcqknfy gaapmmaetq hfflglnirl yagyglsets
      481 gphfmsspyn yrlyssgklv pgcrvklvnq daegigeicl wgrtifmgyl nmedktceai
      541 deegwlhtgd agrldadgfl yitgrlkeli itaggenvpp vpieeavkme lpiisnamli
      601 gdqrkflsml ltlkctldpd tsdqtdnlte qamefcqrvg srattvseii ekkdeavyqa
      661 ieegirrvnm naaarpyhiq kwailerdfs isggelgptm klkrltvlek ykdgvslccp
      721 gwsavarsql tttsaswvqa illpqrpe
//
LOCUS       XP_047288229             732 aa            linear   PRI 05-AUG-2025
DEFINITION  long-chain-fatty-acid--CoA ligase ACSBG1 isoform X2 [Homo sapiens].
ACCESSION   XP_047288229
VERSION     XP_047288229.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432273.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..732
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..732
                     /product="long-chain-fatty-acid--CoA ligase ACSBG1 isoform
                     X2"
                     /calculated_mol_wt=82173
     Region          133..727
                     /region_name="ACSBG_like"
                     /note="Bubblegum-like very long-chain fatty acid CoA
                     synthetase (VL-FACS); cd05933"
                     /db_xref="CDD:341256"
     Site            order(287,290..295,297..298)
                     /site_type="other"
                     /note="acyl-activating enzyme (AAE) consensus motif"
                     /db_xref="CDD:341256"
     Site            order(290,412..413,480..485,558,570,573,585,707)
                     /site_type="other"
                     /note="putative AMP binding site [chemical binding]"
                     /db_xref="CDD:341256"
     Site            order(290,334..335,383,385..386,389,412..413,480..485,558,
                     570,573,582..585,684)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:341256"
     Site            order(334,385..386,389,412,582..584,678,684)
                     /site_type="other"
                     /note="putative CoA binding site [chemical binding]"
                     /db_xref="CDD:341256"
     CDS             1..732
                     /gene="ACSBG1"
                     /gene_synonym="BG; BG1; BGM; GR-LACS; LPD"
                     /coded_by="XM_047432273.1:580..2778"
                     /db_xref="GeneID:23205"
                     /db_xref="HGNC:HGNC:29567"
                     /db_xref="MIM:614362"
ORIGIN      
        1 mpevlllrsa ssilrtafls rwlpggprcv hklsfvrnlq crqgvrlnvr sssltdrqpl
       61 skeslnhale lsvpekvnna qwdapeealw ttradgrvrl ridpscpqlp ytvhrmfyea
      121 ldkygdlial gfkrqdkweh isysqyylla rraakgflkl glkqahsvai lgfnspewff
      181 savgtvfagg ivtgiyttss peacqyiayd ccanvimvdt qkqlekilki wkqlphlkav
      241 viykepppnk manvytmeef melgnevpee aldaiidtqq pnqccvlvyt sgttgnpkgv
      301 mlsqdnitwt arygsqagdi rpaevqqevv vsylplshia aqiydlwtgi qwgaqvcfae
      361 pdalkgslvn tlreveptsh mgvprvweki meriqevaaq sgfirrkmll wamsvtleqn
      421 ltcpgsdlkp fttrladylv lakvrqalgf akcqknfyga apmmaetqhf flglnirlya
      481 gyglsetsgp hfmsspynyr lyssgklvpg crvklvnqda egigeiclwg rtifmgylnm
      541 edktceaide egwlhtgdag rldadgflyi tgrlkeliit aggenvppvp ieeavkmelp
      601 iisnamligd qrkflsmllt lkctldpdts dqtdnlteqa mefcqrvgsr attvseiiek
      661 kdeavyqaie egirrvnmna aarpyhiqkw ailerdfsis ggelgptmkl krltvlekyk
      721 giidsfyqeq km
//
LOCUS       XP_011519692             702 aa            linear   PRI 05-AUG-2025
DEFINITION  long-chain-fatty-acid--CoA ligase ACSBG1 isoform X3 [Homo sapiens].
ACCESSION   XP_011519692
VERSION     XP_011519692.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521390.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..702
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..702
                     /product="long-chain-fatty-acid--CoA ligase ACSBG1 isoform
                     X3"
                     /calculated_mol_wt=78906
     Region          103..697
                     /region_name="ACSBG_like"
                     /note="Bubblegum-like very long-chain fatty acid CoA
                     synthetase (VL-FACS); cd05933"
                     /db_xref="CDD:341256"
     Site            order(257,260..265,267..268)
                     /site_type="other"
                     /note="acyl-activating enzyme (AAE) consensus motif"
                     /db_xref="CDD:341256"
     Site            order(260,382..383,450..455,528,540,543,555,677)
                     /site_type="other"
                     /note="putative AMP binding site [chemical binding]"
                     /db_xref="CDD:341256"
     Site            order(260,304..305,353,355..356,359,382..383,450..455,528,
                     540,543,552..555,654)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:341256"
     Site            order(304,355..356,359,382,552..554,648,654)
                     /site_type="other"
                     /note="putative CoA binding site [chemical binding]"
                     /db_xref="CDD:341256"
     CDS             1..702
                     /gene="ACSBG1"
                     /gene_synonym="BG; BG1; BGM; GR-LACS; LPD"
                     /coded_by="XM_011521390.4:87..2195"
                     /db_xref="GeneID:23205"
                     /db_xref="HGNC:HGNC:29567"
                     /db_xref="MIM:614362"
ORIGIN      
        1 mnrleplhla hyyslilnle issltdrqpl skeslnhale lsvpekvnna qwdapeealw
       61 ttradgrvrl ridpscpqlp ytvhrmfyea ldkygdlial gfkrqdkweh isysqyylla
      121 rraakgflkl glkqahsvai lgfnspewff savgtvfagg ivtgiyttss peacqyiayd
      181 ccanvimvdt qkqlekilki wkqlphlkav viykepppnk manvytmeef melgnevpee
      241 aldaiidtqq pnqccvlvyt sgttgnpkgv mlsqdnitwt arygsqagdi rpaevqqevv
      301 vsylplshia aqiydlwtgi qwgaqvcfae pdalkgslvn tlreveptsh mgvprvweki
      361 meriqevaaq sgfirrkmll wamsvtleqn ltcpgsdlkp fttrladylv lakvrqalgf
      421 akcqknfyga apmmaetqhf flglnirlya gyglsetsgp hfmsspynyr lyssgklvpg
      481 crvklvnqda egigeiclwg rtifmgylnm edktceaide egwlhtgdag rldadgflyi
      541 tgrlkeliit aggenvppvp ieeavkmelp iisnamligd qrkflsmllt lkctldpdts
      601 dqtdnlteqa mefcqrvgsr attvseiiek kdeavyqaie egirrvnmna aarpyhiqkw
      661 ailerdfsis ggelgptmkl krltvlekyk giidsfyqeq km
//
LOCUS       XP_011519693             677 aa            linear   PRI 05-AUG-2025
DEFINITION  long-chain-fatty-acid--CoA ligase ACSBG1 isoform X4 [Homo sapiens].
ACCESSION   XP_011519693
VERSION     XP_011519693.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521391.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Jun 6, 2016 this sequence version replaced XP_011519693.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..677
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..677
                     /product="long-chain-fatty-acid--CoA ligase ACSBG1 isoform
                     X4"
                     /calculated_mol_wt=75673
     Region          54..642
                     /region_name="ACSBG_like"
                     /note="Bubblegum-like very long-chain fatty acid CoA
                     synthetase (VL-FACS); cd05933"
                     /db_xref="CDD:341256"
     Site            order(208,211..216,218..219)
                     /site_type="other"
                     /note="acyl-activating enzyme (AAE) consensus motif"
                     /db_xref="CDD:341256"
     Site            order(211,333..334,401..406,479,491,494,506,628)
                     /site_type="other"
                     /note="putative AMP binding site [chemical binding]"
                     /db_xref="CDD:341256"
     Site            order(211,255..256,304,306..307,310,333..334,401..406,479,
                     491,494,503..506,605)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:341256"
     Site            order(255,306..307,310,333,503..505,599,605)
                     /site_type="other"
                     /note="putative CoA binding site [chemical binding]"
                     /db_xref="CDD:341256"
     CDS             1..677
                     /gene="ACSBG1"
                     /gene_synonym="BG; BG1; BGM; GR-LACS; LPD"
                     /coded_by="XM_011521391.3:7709..9742"
                     /db_xref="GeneID:23205"
                     /db_xref="HGNC:HGNC:29567"
                     /db_xref="MIM:614362"
ORIGIN      
        1 mgeekleeal wttradgrvr lridpscpql pytvhrmfye aldkygdlia lgfkrqdkwe
       61 hisysqyyll arraakgflk lglkqahsva ilgfnspewf fsavgtvfag givtgiytts
      121 speacqyiay dccanvimvd tqkqlekilk iwkqlphlka vviykepppn kmanvytmee
      181 fmelgnevpe ealdaiidtq qpnqccvlvy tsgttgnpkg vmlsqdnitw tarygsqagd
      241 irpaevqqev vvsylplshi aaqiydlwtg iqwgaqvcfa epdalkgslv ntlrevepts
      301 hmgvprvwek imeriqevaa qsgfirrkml lwamsvtleq nltcpgsdlk pfttrladyl
      361 vlakvrqalg fakcqknfyg aapmmaetqh fflglnirly agyglsetsg phfmsspyny
      421 rlyssgklvp gcrvklvnqd aegigeiclw grtifmgyln medktceaid eegwlhtgda
      481 grldadgfly itgrlkelii taggenvppv pieeavkmel piisnamlig dqrkflsmll
      541 tlkctldpdt sdqtdnlteq amefcqrvgs rattvseiie kkdeavyqai eegirrvnmn
      601 aaarpyhiqk wailerdfsi sggelgptmk lkrltvleky kdgvslccpg wsavarsqlt
      661 ttsaswvqai llpqrpe
//
LOCUS       XP_011519694             916 aa            linear   PRI 05-AUG-2025
DEFINITION  major intrinsically disordered Notch2-binding receptor 1 isoform X1
            [Homo sapiens].
ACCESSION   XP_011519694
VERSION     XP_011519694.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521392.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..916
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..916
                     /product="major intrinsically disordered Notch2-binding
                     receptor 1 isoform X1"
                     /calculated_mol_wt=102862
     Region          759..911
                     /region_name="MINAR1_C"
                     /note="MINAR1 C-terminal domain; pfam06789"
                     /db_xref="CDD:462010"
     CDS             1..916
                     /gene="MINAR1"
                     /gene_synonym="KIAA1024; UBTOR"
                     /coded_by="XM_011521392.2:1498..4248"
                     /db_xref="GeneID:23251"
                     /db_xref="HGNC:HGNC:29172"
                     /db_xref="MIM:618054"
ORIGIN      
        1 metsqetslf lvkileelds kqntvsyqdl ckslcarfdl sqlaklrsvl fytacldpnf
       61 patlfkdkmk ctvnnqqskk imvaadivti fnliqmngga akeklptgrq kvrkkeasfe
      121 scrsdteicn aaeceplnce lsersfsrgy pirqsskcrk mdckdcpqfv pasepnfllg
      181 vskevknraa sldrlqalap ysvtspqpce mqrtyfpmni enesisdqds lpinqsiket
      241 fisneepfvv qscvqkrnif kedfhnlmav spslvgpisk aenehrepqs rkephkppff
      301 nhsfempyns qylnpvyspv pdkrrakhes lddlqastyf gptpvmgtqe arrclgkpnk
      361 qtpwpaksws lnteevpdfe rsffnrnpse eklhypnass qtpnfpaper rptylvpkdq
      421 qpilpiayaa kqnglkskei sspvdlekhe pvkkfkdksi nctsgqlssd tssvgtqteh
      481 vlepkkcrdl ctsgqgkysd rhtmkhsddd seivsddisd ifrflddmsi sgstgviqss
      541 cynstgslsq lhksdcdssp ehnltkiang vpnskgdkgn rpenthhsee elktsvcklv
      601 lrigeierkl eslsgvrdei sqvlgklnkl dqkmqqpekv svqidlnslt segpsddsas
      661 prmfhahsgs hgpklennpd wccsdasgsn seslrvkalk kslftrpssr slteensate
      721 skiasisnsp rdwrtitytn rvglneeeik dtgpgdnkdw hrkskeadrq ydippqhrlp
      781 kqpkdgflve qvfsphpypa slkahmksnp lytdmrltel aevkrgqpsw tieeyarnag
      841 dkgkltaldl qtqeslnpnn leywmediyt pgydsllkrk eaefrrakvc kiaaliaaaa
      901 ctvilvivvp ictmks
//
LOCUS       XP_016877516             916 aa            linear   PRI 05-AUG-2025
DEFINITION  major intrinsically disordered Notch2-binding receptor 1 isoform X1
            [Homo sapiens].
ACCESSION   XP_016877516
VERSION     XP_016877516.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022027.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..916
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..916
                     /product="major intrinsically disordered Notch2-binding
                     receptor 1 isoform X1"
                     /calculated_mol_wt=102862
     Region          759..911
                     /region_name="MINAR1_C"
                     /note="MINAR1 C-terminal domain; pfam06789"
                     /db_xref="CDD:462010"
     CDS             1..916
                     /gene="MINAR1"
                     /gene_synonym="KIAA1024; UBTOR"
                     /coded_by="XM_017022027.2:292..3042"
                     /db_xref="GeneID:23251"
                     /db_xref="HGNC:HGNC:29172"
                     /db_xref="MIM:618054"
ORIGIN      
        1 metsqetslf lvkileelds kqntvsyqdl ckslcarfdl sqlaklrsvl fytacldpnf
       61 patlfkdkmk ctvnnqqskk imvaadivti fnliqmngga akeklptgrq kvrkkeasfe
      121 scrsdteicn aaeceplnce lsersfsrgy pirqsskcrk mdckdcpqfv pasepnfllg
      181 vskevknraa sldrlqalap ysvtspqpce mqrtyfpmni enesisdqds lpinqsiket
      241 fisneepfvv qscvqkrnif kedfhnlmav spslvgpisk aenehrepqs rkephkppff
      301 nhsfempyns qylnpvyspv pdkrrakhes lddlqastyf gptpvmgtqe arrclgkpnk
      361 qtpwpaksws lnteevpdfe rsffnrnpse eklhypnass qtpnfpaper rptylvpkdq
      421 qpilpiayaa kqnglkskei sspvdlekhe pvkkfkdksi nctsgqlssd tssvgtqteh
      481 vlepkkcrdl ctsgqgkysd rhtmkhsddd seivsddisd ifrflddmsi sgstgviqss
      541 cynstgslsq lhksdcdssp ehnltkiang vpnskgdkgn rpenthhsee elktsvcklv
      601 lrigeierkl eslsgvrdei sqvlgklnkl dqkmqqpekv svqidlnslt segpsddsas
      661 prmfhahsgs hgpklennpd wccsdasgsn seslrvkalk kslftrpssr slteensate
      721 skiasisnsp rdwrtitytn rvglneeeik dtgpgdnkdw hrkskeadrq ydippqhrlp
      781 kqpkdgflve qvfsphpypa slkahmksnp lytdmrltel aevkrgqpsw tieeyarnag
      841 dkgkltaldl qtqeslnpnn leywmediyt pgydsllkrk eaefrrakvc kiaaliaaaa
      901 ctvilvivvp ictmks
//
LOCUS       XP_011519697             916 aa            linear   PRI 05-AUG-2025
DEFINITION  major intrinsically disordered Notch2-binding receptor 1 isoform X1
            [Homo sapiens].
ACCESSION   XP_011519697
VERSION     XP_011519697.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521395.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..916
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..916
                     /product="major intrinsically disordered Notch2-binding
                     receptor 1 isoform X1"
                     /calculated_mol_wt=102862
     Region          759..911
                     /region_name="MINAR1_C"
                     /note="MINAR1 C-terminal domain; pfam06789"
                     /db_xref="CDD:462010"
     CDS             1..916
                     /gene="MINAR1"
                     /gene_synonym="KIAA1024; UBTOR"
                     /coded_by="XM_011521395.3:1302..4052"
                     /db_xref="GeneID:23251"
                     /db_xref="HGNC:HGNC:29172"
                     /db_xref="MIM:618054"
ORIGIN      
        1 metsqetslf lvkileelds kqntvsyqdl ckslcarfdl sqlaklrsvl fytacldpnf
       61 patlfkdkmk ctvnnqqskk imvaadivti fnliqmngga akeklptgrq kvrkkeasfe
      121 scrsdteicn aaeceplnce lsersfsrgy pirqsskcrk mdckdcpqfv pasepnfllg
      181 vskevknraa sldrlqalap ysvtspqpce mqrtyfpmni enesisdqds lpinqsiket
      241 fisneepfvv qscvqkrnif kedfhnlmav spslvgpisk aenehrepqs rkephkppff
      301 nhsfempyns qylnpvyspv pdkrrakhes lddlqastyf gptpvmgtqe arrclgkpnk
      361 qtpwpaksws lnteevpdfe rsffnrnpse eklhypnass qtpnfpaper rptylvpkdq
      421 qpilpiayaa kqnglkskei sspvdlekhe pvkkfkdksi nctsgqlssd tssvgtqteh
      481 vlepkkcrdl ctsgqgkysd rhtmkhsddd seivsddisd ifrflddmsi sgstgviqss
      541 cynstgslsq lhksdcdssp ehnltkiang vpnskgdkgn rpenthhsee elktsvcklv
      601 lrigeierkl eslsgvrdei sqvlgklnkl dqkmqqpekv svqidlnslt segpsddsas
      661 prmfhahsgs hgpklennpd wccsdasgsn seslrvkalk kslftrpssr slteensate
      721 skiasisnsp rdwrtitytn rvglneeeik dtgpgdnkdw hrkskeadrq ydippqhrlp
      781 kqpkdgflve qvfsphpypa slkahmksnp lytdmrltel aevkrgqpsw tieeyarnag
      841 dkgkltaldl qtqeslnpnn leywmediyt pgydsllkrk eaefrrakvc kiaaliaaaa
      901 ctvilvivvp ictmks
//
LOCUS       XP_011519698             916 aa            linear   PRI 05-AUG-2025
DEFINITION  major intrinsically disordered Notch2-binding receptor 1 isoform X1
            [Homo sapiens].
ACCESSION   XP_011519698
VERSION     XP_011519698.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521396.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..916
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..916
                     /product="major intrinsically disordered Notch2-binding
                     receptor 1 isoform X1"
                     /calculated_mol_wt=102862
     Region          759..911
                     /region_name="MINAR1_C"
                     /note="MINAR1 C-terminal domain; pfam06789"
                     /db_xref="CDD:462010"
     CDS             1..916
                     /gene="MINAR1"
                     /gene_synonym="KIAA1024; UBTOR"
                     /coded_by="XM_011521396.3:170..2920"
                     /db_xref="GeneID:23251"
                     /db_xref="HGNC:HGNC:29172"
                     /db_xref="MIM:618054"
ORIGIN      
        1 metsqetslf lvkileelds kqntvsyqdl ckslcarfdl sqlaklrsvl fytacldpnf
       61 patlfkdkmk ctvnnqqskk imvaadivti fnliqmngga akeklptgrq kvrkkeasfe
      121 scrsdteicn aaeceplnce lsersfsrgy pirqsskcrk mdckdcpqfv pasepnfllg
      181 vskevknraa sldrlqalap ysvtspqpce mqrtyfpmni enesisdqds lpinqsiket
      241 fisneepfvv qscvqkrnif kedfhnlmav spslvgpisk aenehrepqs rkephkppff
      301 nhsfempyns qylnpvyspv pdkrrakhes lddlqastyf gptpvmgtqe arrclgkpnk
      361 qtpwpaksws lnteevpdfe rsffnrnpse eklhypnass qtpnfpaper rptylvpkdq
      421 qpilpiayaa kqnglkskei sspvdlekhe pvkkfkdksi nctsgqlssd tssvgtqteh
      481 vlepkkcrdl ctsgqgkysd rhtmkhsddd seivsddisd ifrflddmsi sgstgviqss
      541 cynstgslsq lhksdcdssp ehnltkiang vpnskgdkgn rpenthhsee elktsvcklv
      601 lrigeierkl eslsgvrdei sqvlgklnkl dqkmqqpekv svqidlnslt segpsddsas
      661 prmfhahsgs hgpklennpd wccsdasgsn seslrvkalk kslftrpssr slteensate
      721 skiasisnsp rdwrtitytn rvglneeeik dtgpgdnkdw hrkskeadrq ydippqhrlp
      781 kqpkdgflve qvfsphpypa slkahmksnp lytdmrltel aevkrgqpsw tieeyarnag
      841 dkgkltaldl qtqeslnpnn leywmediyt pgydsllkrk eaefrrakvc kiaaliaaaa
      901 ctvilvivvp ictmks
//
LOCUS       XP_011519695             916 aa            linear   PRI 05-AUG-2025
DEFINITION  major intrinsically disordered Notch2-binding receptor 1 isoform X1
            [Homo sapiens].
ACCESSION   XP_011519695
VERSION     XP_011519695.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521393.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..916
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..916
                     /product="major intrinsically disordered Notch2-binding
                     receptor 1 isoform X1"
                     /calculated_mol_wt=102862
     Region          759..911
                     /region_name="MINAR1_C"
                     /note="MINAR1 C-terminal domain; pfam06789"
                     /db_xref="CDD:462010"
     CDS             1..916
                     /gene="MINAR1"
                     /gene_synonym="KIAA1024; UBTOR"
                     /coded_by="XM_011521393.4:2739..5489"
                     /db_xref="GeneID:23251"
                     /db_xref="HGNC:HGNC:29172"
                     /db_xref="MIM:618054"
ORIGIN      
        1 metsqetslf lvkileelds kqntvsyqdl ckslcarfdl sqlaklrsvl fytacldpnf
       61 patlfkdkmk ctvnnqqskk imvaadivti fnliqmngga akeklptgrq kvrkkeasfe
      121 scrsdteicn aaeceplnce lsersfsrgy pirqsskcrk mdckdcpqfv pasepnfllg
      181 vskevknraa sldrlqalap ysvtspqpce mqrtyfpmni enesisdqds lpinqsiket
      241 fisneepfvv qscvqkrnif kedfhnlmav spslvgpisk aenehrepqs rkephkppff
      301 nhsfempyns qylnpvyspv pdkrrakhes lddlqastyf gptpvmgtqe arrclgkpnk
      361 qtpwpaksws lnteevpdfe rsffnrnpse eklhypnass qtpnfpaper rptylvpkdq
      421 qpilpiayaa kqnglkskei sspvdlekhe pvkkfkdksi nctsgqlssd tssvgtqteh
      481 vlepkkcrdl ctsgqgkysd rhtmkhsddd seivsddisd ifrflddmsi sgstgviqss
      541 cynstgslsq lhksdcdssp ehnltkiang vpnskgdkgn rpenthhsee elktsvcklv
      601 lrigeierkl eslsgvrdei sqvlgklnkl dqkmqqpekv svqidlnslt segpsddsas
      661 prmfhahsgs hgpklennpd wccsdasgsn seslrvkalk kslftrpssr slteensate
      721 skiasisnsp rdwrtitytn rvglneeeik dtgpgdnkdw hrkskeadrq ydippqhrlp
      781 kqpkdgflve qvfsphpypa slkahmksnp lytdmrltel aevkrgqpsw tieeyarnag
      841 dkgkltaldl qtqeslnpnn leywmediyt pgydsllkrk eaefrrakvc kiaaliaaaa
      901 ctvilvivvp ictmks
//
LOCUS       XP_005254300            3115 aa            linear   PRI 05-AUG-2025
DEFINITION  MAX gene-associated protein isoform X1 [Homo sapiens].
ACCESSION   XP_005254300
VERSION     XP_005254300.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254243.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..3115
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..3115
                     /product="MAX gene-associated protein isoform X1"
                     /calculated_mol_wt=341332
     Region          75..260
                     /region_name="T-box_MGA-like"
                     /note="DNA-binding domain of MAX gene-associated protein
                     and related T-box proteins; cd20195"
                     /db_xref="CDD:410321"
     Site            order(102..103,136,180,183,196..197,237..240,245,248..249,
                     252..258)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410321"
     Region          1041..1082
                     /region_name="MGA_dom"
                     /note="MGA, conserved domain; pfam16059"
                     /db_xref="CDD:464998"
     Region          <1519..1820
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          1710..>2032
                     /region_name="Atrophin-1"
                     /note="Atrophin-1 family; pfam03154"
                     /db_xref="CDD:460830"
     Region          2475..2539
                     /region_name="bHLHzip_MGA"
                     /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain
                     found in MAX gene-associated protein (MGA) and similar
                     proteins; cd18911"
                     /db_xref="CDD:381481"
     Site            order(2475,2477..2479,2481..2483,2485..2486,2490,
                     2509..2510)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381481"
     Site            order(2489,2492..2493,2495..2496,2499..2501,2511,
                     2514..2515,2518,2520..2522,2524..2525,2527..2528,2531,
                     2534..2535,2538..2539)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381481"
     CDS             1..3115
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /coded_by="XM_005254243.4:189..9536"
                     /db_xref="GeneID:23269"
                     /db_xref="HGNC:HGNC:14010"
                     /db_xref="MIM:616061"
ORIGIN      
        1 meekqqiila nqdggtvaga aptffvilkq pgngktdqgi lvtnqdacal assvsspvks
       61 kgkiclpadc tvggitvtld nnsmwnefyh rstemiltkq grrmfpycry witgldsnlk
      121 yilvmdispv dnhrykwngr wwepsgkaep hvlgrvfihp espstghywm hqpvsfyklk
      181 ltnntldqeg hiilhsmhry lprlhlvpae kaveviqlng pgvhtftfpq teffavtayq
      241 niqitqlkid ynpfakgfrd dglnnkpqrd gkqknssdqe gnnissssgh rvrltegqgs
      301 eiqpgdldpl srghetsgkg lektslnikr dflgfmdtds alsevpqlkq eisecliass
      361 feddsrvasp ldqngsfnvv ikeeplddyd yelgecpegv tvkqeetdee tdvysnsddd
      421 pilekqlkrh nkvdnpeadh lsskwlpssp sgvakakmfk ldtgkmpvvy lepcavtrst
      481 vkiselpdnm lstsrkdkss mlaeleylpt yiensnetaf clgkesengl rkhspdlrvv
      541 qkypllkepq wkypdisdsi sterilddsk dsvgdslsgk edlgrkrttm lkiataakvv
      601 nanqnaspnv pgkrgrprkl klckagrppk ntgkslistk ntpvspgstf pdvkpdledv
      661 dgvlfvsfes kealdihavd gtteessslq asttndsgyr arisqlekel iedlktlrhk
      721 qvihpglqev glklnsvdpt msidlkylgv qlplapatsf pfwnltgtnp aspdagfpfv
      781 srtgktndft kikgwrgkfh sasasrnegg nsesslknrs afcsdkldey lenegklmet
      841 smgfssnapt spvvyqlptk stsyvrtlds vlkkqstisp stsyslkphs vppvsrkaks
      901 qnrqatfsgr tkssyksilp ypvspkqkys hvilgdkvtk nssgiisenq annfvvptld
      961 enifpkqisl rqaqqqqqqq qgsrppglsk sqvklmdled calwegkprt yiteeradvs
     1021 lttlltaqas lktkpihtii rkrappcnnd fcrlgcvcss lalekrqpah crrpdcmfgc
     1081 tclkrkvvlv kggsktkhfq rkaahrdpvf ydtlgeeare eeegireeee qlkekkkrkk
     1141 leyticetep eqpvrhyplw vkvegevdpe pvyiptpsvi epmkplllpq pevlsptvkg
     1201 klltgikspr sytpkpnpvi reedkdpvyl yfesmmtcar vrvyerkked qrqpsssssp
     1261 spsfqqqtsc hsspenhnna kepdseqqpl kqltcdledd sdklqekswk sscnegesss
     1321 tsymhqrspg gptklieiis dcnweedrnk ilsilsqhin snmpqslkvg sfiielasqr
     1381 ksrgeknppv yssrvkismp scqdqddmae ksgsetpdgp lspgkmedis pvqtdaldsv
     1441 rerlhggkgl pfyaglspag klvaykrkps sstsgliqvn gksypqakll lgqmgalhpa
     1501 nrlaayitgr lrpsvldlst lstviskvas nakvaasrkp rtllpstsns kmasssgtat
     1561 nrpgknlkaf vpakrpiaar pspggvftqf vmskvgalqq kipgvstpqt lagtqkfsir
     1621 pspvmvvtpv vssepvqvcs pvtaavtttt pqvflentta vtpmtaisdv etkettyssg
     1681 atttgvvevs etntstsvts tqstatvnlt kttgittpva svafpkslva spstitlpva
     1741 stastslvvv taaasssmvt tptsslgsvp iilsgingsp pvsqrpenaa qipvatpqvs
     1801 pntvkragpr lllipvqqgs ptlrpvsntq lqghrmvlqp vrspsgmnlf rhpngqivql
     1861 lplhqlrgsn tqpnlqpvmf rnpgsvmgir lpapskpset ppsstsssaf svmnpviqav
     1921 gsssavnvit qapsllssga sfvsqagtlt lrisppepqs fasktgsetk ityssggqpv
     1981 gtasliplqs gsfallqlpg qkpvpssilq hvaslqmkre sqnpdqkdet nsikreqetk
     2041 kvlqsegeav dpeanvikqn sgaatseetl ndsledrgdh ldeeclpeeg catvkpsehs
     2101 citgshtdqd ykdvneeyga rnrksskekv avlevrtise kasnktvqnl skvqhqklgd
     2161 vkveqqkgfd npeenssefp vtfkeeskfe lsgskvmeqq snlqpeakek ecgdslekdr
     2221 erwrkhlkgp ltrkcvgasq eckkeadeql iketktcqen sdvfqqeqgi sdllgksgit
     2281 edarvlktec dswsrisnps afsivprraa kssrgnghfq ghlllpgeqi qpkqekkggr
     2341 ssadftvldl eeddeddnek tddsideivd vvsdyqseev ddvekvnncv eyieddeehv
     2401 dietveelse einvahlktt aahtqsfkqp scthisadek aaersrkapp iplklkpdyw
     2461 sdklqkeaea fayyrrthta nerrrrgemr dlfeklkitl gllhsskvsk sliltrafse
     2521 iqgltdqadk ligqknlltr krnilirkvs slsgkteevv lkkleyiyak qqaleaqkrk
     2581 kkmgsdefdi spriskqqeg ssassvdlgq mfinnrrgkp lilsrkkdqa tentsplntp
     2641 htsanlvmtp qgqlltlkgp lfsgpvvavs pdllesdlkp qvagsavalp enddlfmmpr
     2701 ivnvtslate gglvdmggsk yphevpdskp sdhlkdtvrn ednsledkgr issrgnrdgr
     2761 vtlgptqvfl ankdsgypqi vdvsnmqkaq eflpkkisgd mrgiqykwke sesrgervks
     2821 kdssfhklkm kdlkdssiem elrkvtsaie eaaldssell tnmededdtd etltsllnei
     2881 aflnqqlndd svglaelpss mdtefpgdar rafiskvppg sratfqvehl gtglkelpdv
     2941 qgesdsispl llhledddfs enekqlaepa sepdvlkivi dseikdslls nkkaidggkn
     3001 tsglpaepes vsspptlhmk tglensnstd tlwrpmpkla plglkvanps sdadgqslkv
     3061 mpclapiaak vgsvghkmnl tgndqegres kvmptlapvv aklgnsgasp ssagk
//
LOCUS       XP_005254303            3115 aa            linear   PRI 05-AUG-2025
DEFINITION  MAX gene-associated protein isoform X1 [Homo sapiens].
ACCESSION   XP_005254303
VERSION     XP_005254303.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254246.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..3115
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..3115
                     /product="MAX gene-associated protein isoform X1"
                     /calculated_mol_wt=341332
     Region          75..260
                     /region_name="T-box_MGA-like"
                     /note="DNA-binding domain of MAX gene-associated protein
                     and related T-box proteins; cd20195"
                     /db_xref="CDD:410321"
     Site            order(102..103,136,180,183,196..197,237..240,245,248..249,
                     252..258)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410321"
     Region          1041..1082
                     /region_name="MGA_dom"
                     /note="MGA, conserved domain; pfam16059"
                     /db_xref="CDD:464998"
     Region          <1519..1820
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          1710..>2032
                     /region_name="Atrophin-1"
                     /note="Atrophin-1 family; pfam03154"
                     /db_xref="CDD:460830"
     Region          2475..2539
                     /region_name="bHLHzip_MGA"
                     /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain
                     found in MAX gene-associated protein (MGA) and similar
                     proteins; cd18911"
                     /db_xref="CDD:381481"
     Site            order(2475,2477..2479,2481..2483,2485..2486,2490,
                     2509..2510)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381481"
     Site            order(2489,2492..2493,2495..2496,2499..2501,2511,
                     2514..2515,2518,2520..2522,2524..2525,2527..2528,2531,
                     2534..2535,2538..2539)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381481"
     CDS             1..3115
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /coded_by="XM_005254246.4:143..9490"
                     /db_xref="GeneID:23269"
                     /db_xref="HGNC:HGNC:14010"
                     /db_xref="MIM:616061"
ORIGIN      
        1 meekqqiila nqdggtvaga aptffvilkq pgngktdqgi lvtnqdacal assvsspvks
       61 kgkiclpadc tvggitvtld nnsmwnefyh rstemiltkq grrmfpycry witgldsnlk
      121 yilvmdispv dnhrykwngr wwepsgkaep hvlgrvfihp espstghywm hqpvsfyklk
      181 ltnntldqeg hiilhsmhry lprlhlvpae kaveviqlng pgvhtftfpq teffavtayq
      241 niqitqlkid ynpfakgfrd dglnnkpqrd gkqknssdqe gnnissssgh rvrltegqgs
      301 eiqpgdldpl srghetsgkg lektslnikr dflgfmdtds alsevpqlkq eisecliass
      361 feddsrvasp ldqngsfnvv ikeeplddyd yelgecpegv tvkqeetdee tdvysnsddd
      421 pilekqlkrh nkvdnpeadh lsskwlpssp sgvakakmfk ldtgkmpvvy lepcavtrst
      481 vkiselpdnm lstsrkdkss mlaeleylpt yiensnetaf clgkesengl rkhspdlrvv
      541 qkypllkepq wkypdisdsi sterilddsk dsvgdslsgk edlgrkrttm lkiataakvv
      601 nanqnaspnv pgkrgrprkl klckagrppk ntgkslistk ntpvspgstf pdvkpdledv
      661 dgvlfvsfes kealdihavd gtteessslq asttndsgyr arisqlekel iedlktlrhk
      721 qvihpglqev glklnsvdpt msidlkylgv qlplapatsf pfwnltgtnp aspdagfpfv
      781 srtgktndft kikgwrgkfh sasasrnegg nsesslknrs afcsdkldey lenegklmet
      841 smgfssnapt spvvyqlptk stsyvrtlds vlkkqstisp stsyslkphs vppvsrkaks
      901 qnrqatfsgr tkssyksilp ypvspkqkys hvilgdkvtk nssgiisenq annfvvptld
      961 enifpkqisl rqaqqqqqqq qgsrppglsk sqvklmdled calwegkprt yiteeradvs
     1021 lttlltaqas lktkpihtii rkrappcnnd fcrlgcvcss lalekrqpah crrpdcmfgc
     1081 tclkrkvvlv kggsktkhfq rkaahrdpvf ydtlgeeare eeegireeee qlkekkkrkk
     1141 leyticetep eqpvrhyplw vkvegevdpe pvyiptpsvi epmkplllpq pevlsptvkg
     1201 klltgikspr sytpkpnpvi reedkdpvyl yfesmmtcar vrvyerkked qrqpsssssp
     1261 spsfqqqtsc hsspenhnna kepdseqqpl kqltcdledd sdklqekswk sscnegesss
     1321 tsymhqrspg gptklieiis dcnweedrnk ilsilsqhin snmpqslkvg sfiielasqr
     1381 ksrgeknppv yssrvkismp scqdqddmae ksgsetpdgp lspgkmedis pvqtdaldsv
     1441 rerlhggkgl pfyaglspag klvaykrkps sstsgliqvn gksypqakll lgqmgalhpa
     1501 nrlaayitgr lrpsvldlst lstviskvas nakvaasrkp rtllpstsns kmasssgtat
     1561 nrpgknlkaf vpakrpiaar pspggvftqf vmskvgalqq kipgvstpqt lagtqkfsir
     1621 pspvmvvtpv vssepvqvcs pvtaavtttt pqvflentta vtpmtaisdv etkettyssg
     1681 atttgvvevs etntstsvts tqstatvnlt kttgittpva svafpkslva spstitlpva
     1741 stastslvvv taaasssmvt tptsslgsvp iilsgingsp pvsqrpenaa qipvatpqvs
     1801 pntvkragpr lllipvqqgs ptlrpvsntq lqghrmvlqp vrspsgmnlf rhpngqivql
     1861 lplhqlrgsn tqpnlqpvmf rnpgsvmgir lpapskpset ppsstsssaf svmnpviqav
     1921 gsssavnvit qapsllssga sfvsqagtlt lrisppepqs fasktgsetk ityssggqpv
     1981 gtasliplqs gsfallqlpg qkpvpssilq hvaslqmkre sqnpdqkdet nsikreqetk
     2041 kvlqsegeav dpeanvikqn sgaatseetl ndsledrgdh ldeeclpeeg catvkpsehs
     2101 citgshtdqd ykdvneeyga rnrksskekv avlevrtise kasnktvqnl skvqhqklgd
     2161 vkveqqkgfd npeenssefp vtfkeeskfe lsgskvmeqq snlqpeakek ecgdslekdr
     2221 erwrkhlkgp ltrkcvgasq eckkeadeql iketktcqen sdvfqqeqgi sdllgksgit
     2281 edarvlktec dswsrisnps afsivprraa kssrgnghfq ghlllpgeqi qpkqekkggr
     2341 ssadftvldl eeddeddnek tddsideivd vvsdyqseev ddvekvnncv eyieddeehv
     2401 dietveelse einvahlktt aahtqsfkqp scthisadek aaersrkapp iplklkpdyw
     2461 sdklqkeaea fayyrrthta nerrrrgemr dlfeklkitl gllhsskvsk sliltrafse
     2521 iqgltdqadk ligqknlltr krnilirkvs slsgkteevv lkkleyiyak qqaleaqkrk
     2581 kkmgsdefdi spriskqqeg ssassvdlgq mfinnrrgkp lilsrkkdqa tentsplntp
     2641 htsanlvmtp qgqlltlkgp lfsgpvvavs pdllesdlkp qvagsavalp enddlfmmpr
     2701 ivnvtslate gglvdmggsk yphevpdskp sdhlkdtvrn ednsledkgr issrgnrdgr
     2761 vtlgptqvfl ankdsgypqi vdvsnmqkaq eflpkkisgd mrgiqykwke sesrgervks
     2821 kdssfhklkm kdlkdssiem elrkvtsaie eaaldssell tnmededdtd etltsllnei
     2881 aflnqqlndd svglaelpss mdtefpgdar rafiskvppg sratfqvehl gtglkelpdv
     2941 qgesdsispl llhledddfs enekqlaepa sepdvlkivi dseikdslls nkkaidggkn
     3001 tsglpaepes vsspptlhmk tglensnstd tlwrpmpkla plglkvanps sdadgqslkv
     3061 mpclapiaak vgsvghkmnl tgndqegres kvmptlapvv aklgnsgasp ssagk
//
LOCUS       XP_006720506            3115 aa            linear   PRI 05-AUG-2025
DEFINITION  MAX gene-associated protein isoform X1 [Homo sapiens].
ACCESSION   XP_006720506
VERSION     XP_006720506.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720443.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..3115
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..3115
                     /product="MAX gene-associated protein isoform X1"
                     /calculated_mol_wt=341332
     Region          75..260
                     /region_name="T-box_MGA-like"
                     /note="DNA-binding domain of MAX gene-associated protein
                     and related T-box proteins; cd20195"
                     /db_xref="CDD:410321"
     Site            order(102..103,136,180,183,196..197,237..240,245,248..249,
                     252..258)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410321"
     Region          1041..1082
                     /region_name="MGA_dom"
                     /note="MGA, conserved domain; pfam16059"
                     /db_xref="CDD:464998"
     Region          <1519..1820
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          1710..>2032
                     /region_name="Atrophin-1"
                     /note="Atrophin-1 family; pfam03154"
                     /db_xref="CDD:460830"
     Region          2475..2539
                     /region_name="bHLHzip_MGA"
                     /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain
                     found in MAX gene-associated protein (MGA) and similar
                     proteins; cd18911"
                     /db_xref="CDD:381481"
     Site            order(2475,2477..2479,2481..2483,2485..2486,2490,
                     2509..2510)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381481"
     Site            order(2489,2492..2493,2495..2496,2499..2501,2511,
                     2514..2515,2518,2520..2522,2524..2525,2527..2528,2531,
                     2534..2535,2538..2539)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381481"
     CDS             1..3115
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /coded_by="XM_006720443.5:165..9512"
                     /db_xref="GeneID:23269"
                     /db_xref="HGNC:HGNC:14010"
                     /db_xref="MIM:616061"
ORIGIN      
        1 meekqqiila nqdggtvaga aptffvilkq pgngktdqgi lvtnqdacal assvsspvks
       61 kgkiclpadc tvggitvtld nnsmwnefyh rstemiltkq grrmfpycry witgldsnlk
      121 yilvmdispv dnhrykwngr wwepsgkaep hvlgrvfihp espstghywm hqpvsfyklk
      181 ltnntldqeg hiilhsmhry lprlhlvpae kaveviqlng pgvhtftfpq teffavtayq
      241 niqitqlkid ynpfakgfrd dglnnkpqrd gkqknssdqe gnnissssgh rvrltegqgs
      301 eiqpgdldpl srghetsgkg lektslnikr dflgfmdtds alsevpqlkq eisecliass
      361 feddsrvasp ldqngsfnvv ikeeplddyd yelgecpegv tvkqeetdee tdvysnsddd
      421 pilekqlkrh nkvdnpeadh lsskwlpssp sgvakakmfk ldtgkmpvvy lepcavtrst
      481 vkiselpdnm lstsrkdkss mlaeleylpt yiensnetaf clgkesengl rkhspdlrvv
      541 qkypllkepq wkypdisdsi sterilddsk dsvgdslsgk edlgrkrttm lkiataakvv
      601 nanqnaspnv pgkrgrprkl klckagrppk ntgkslistk ntpvspgstf pdvkpdledv
      661 dgvlfvsfes kealdihavd gtteessslq asttndsgyr arisqlekel iedlktlrhk
      721 qvihpglqev glklnsvdpt msidlkylgv qlplapatsf pfwnltgtnp aspdagfpfv
      781 srtgktndft kikgwrgkfh sasasrnegg nsesslknrs afcsdkldey lenegklmet
      841 smgfssnapt spvvyqlptk stsyvrtlds vlkkqstisp stsyslkphs vppvsrkaks
      901 qnrqatfsgr tkssyksilp ypvspkqkys hvilgdkvtk nssgiisenq annfvvptld
      961 enifpkqisl rqaqqqqqqq qgsrppglsk sqvklmdled calwegkprt yiteeradvs
     1021 lttlltaqas lktkpihtii rkrappcnnd fcrlgcvcss lalekrqpah crrpdcmfgc
     1081 tclkrkvvlv kggsktkhfq rkaahrdpvf ydtlgeeare eeegireeee qlkekkkrkk
     1141 leyticetep eqpvrhyplw vkvegevdpe pvyiptpsvi epmkplllpq pevlsptvkg
     1201 klltgikspr sytpkpnpvi reedkdpvyl yfesmmtcar vrvyerkked qrqpsssssp
     1261 spsfqqqtsc hsspenhnna kepdseqqpl kqltcdledd sdklqekswk sscnegesss
     1321 tsymhqrspg gptklieiis dcnweedrnk ilsilsqhin snmpqslkvg sfiielasqr
     1381 ksrgeknppv yssrvkismp scqdqddmae ksgsetpdgp lspgkmedis pvqtdaldsv
     1441 rerlhggkgl pfyaglspag klvaykrkps sstsgliqvn gksypqakll lgqmgalhpa
     1501 nrlaayitgr lrpsvldlst lstviskvas nakvaasrkp rtllpstsns kmasssgtat
     1561 nrpgknlkaf vpakrpiaar pspggvftqf vmskvgalqq kipgvstpqt lagtqkfsir
     1621 pspvmvvtpv vssepvqvcs pvtaavtttt pqvflentta vtpmtaisdv etkettyssg
     1681 atttgvvevs etntstsvts tqstatvnlt kttgittpva svafpkslva spstitlpva
     1741 stastslvvv taaasssmvt tptsslgsvp iilsgingsp pvsqrpenaa qipvatpqvs
     1801 pntvkragpr lllipvqqgs ptlrpvsntq lqghrmvlqp vrspsgmnlf rhpngqivql
     1861 lplhqlrgsn tqpnlqpvmf rnpgsvmgir lpapskpset ppsstsssaf svmnpviqav
     1921 gsssavnvit qapsllssga sfvsqagtlt lrisppepqs fasktgsetk ityssggqpv
     1981 gtasliplqs gsfallqlpg qkpvpssilq hvaslqmkre sqnpdqkdet nsikreqetk
     2041 kvlqsegeav dpeanvikqn sgaatseetl ndsledrgdh ldeeclpeeg catvkpsehs
     2101 citgshtdqd ykdvneeyga rnrksskekv avlevrtise kasnktvqnl skvqhqklgd
     2161 vkveqqkgfd npeenssefp vtfkeeskfe lsgskvmeqq snlqpeakek ecgdslekdr
     2221 erwrkhlkgp ltrkcvgasq eckkeadeql iketktcqen sdvfqqeqgi sdllgksgit
     2281 edarvlktec dswsrisnps afsivprraa kssrgnghfq ghlllpgeqi qpkqekkggr
     2341 ssadftvldl eeddeddnek tddsideivd vvsdyqseev ddvekvnncv eyieddeehv
     2401 dietveelse einvahlktt aahtqsfkqp scthisadek aaersrkapp iplklkpdyw
     2461 sdklqkeaea fayyrrthta nerrrrgemr dlfeklkitl gllhsskvsk sliltrafse
     2521 iqgltdqadk ligqknlltr krnilirkvs slsgkteevv lkkleyiyak qqaleaqkrk
     2581 kkmgsdefdi spriskqqeg ssassvdlgq mfinnrrgkp lilsrkkdqa tentsplntp
     2641 htsanlvmtp qgqlltlkgp lfsgpvvavs pdllesdlkp qvagsavalp enddlfmmpr
     2701 ivnvtslate gglvdmggsk yphevpdskp sdhlkdtvrn ednsledkgr issrgnrdgr
     2761 vtlgptqvfl ankdsgypqi vdvsnmqkaq eflpkkisgd mrgiqykwke sesrgervks
     2821 kdssfhklkm kdlkdssiem elrkvtsaie eaaldssell tnmededdtd etltsllnei
     2881 aflnqqlndd svglaelpss mdtefpgdar rafiskvppg sratfqvehl gtglkelpdv
     2941 qgesdsispl llhledddfs enekqlaepa sepdvlkivi dseikdslls nkkaidggkn
     3001 tsglpaepes vsspptlhmk tglensnstd tlwrpmpkla plglkvanps sdadgqslkv
     3061 mpclapiaak vgsvghkmnl tgndqegres kvmptlapvv aklgnsgasp ssagk
//
LOCUS       XP_047288232            3114 aa            linear   PRI 05-AUG-2025
DEFINITION  MAX gene-associated protein isoform X2 [Homo sapiens].
ACCESSION   XP_047288232
VERSION     XP_047288232.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432276.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..3114
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..3114
                     /product="MAX gene-associated protein isoform X2"
                     /calculated_mol_wt=341233
     Region          75..260
                     /region_name="T-box_MGA-like"
                     /note="DNA-binding domain of MAX gene-associated protein
                     and related T-box proteins; cd20195"
                     /db_xref="CDD:410321"
     Site            order(102..103,136,180,183,196..197,237..240,245,248..249,
                     252..258)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410321"
     Region          1041..1082
                     /region_name="MGA_dom"
                     /note="MGA, conserved domain; pfam16059"
                     /db_xref="CDD:464998"
     Region          <1519..1820
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          1710..>2032
                     /region_name="Atrophin-1"
                     /note="Atrophin-1 family; pfam03154"
                     /db_xref="CDD:460830"
     Region          2474..2538
                     /region_name="bHLHzip_MGA"
                     /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain
                     found in MAX gene-associated protein (MGA) and similar
                     proteins; cd18911"
                     /db_xref="CDD:381481"
     Site            order(2474,2476..2478,2480..2482,2484..2485,2489,
                     2508..2509)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381481"
     Site            order(2488,2491..2492,2494..2495,2498..2500,2510,
                     2513..2514,2517,2519..2521,2523..2524,2526..2527,2530,
                     2533..2534,2537..2538)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381481"
     CDS             1..3114
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /coded_by="XM_047432276.1:143..9487"
                     /db_xref="GeneID:23269"
                     /db_xref="HGNC:HGNC:14010"
                     /db_xref="MIM:616061"
ORIGIN      
        1 meekqqiila nqdggtvaga aptffvilkq pgngktdqgi lvtnqdacal assvsspvks
       61 kgkiclpadc tvggitvtld nnsmwnefyh rstemiltkq grrmfpycry witgldsnlk
      121 yilvmdispv dnhrykwngr wwepsgkaep hvlgrvfihp espstghywm hqpvsfyklk
      181 ltnntldqeg hiilhsmhry lprlhlvpae kaveviqlng pgvhtftfpq teffavtayq
      241 niqitqlkid ynpfakgfrd dglnnkpqrd gkqknssdqe gnnissssgh rvrltegqgs
      301 eiqpgdldpl srghetsgkg lektslnikr dflgfmdtds alsevpqlkq eisecliass
      361 feddsrvasp ldqngsfnvv ikeeplddyd yelgecpegv tvkqeetdee tdvysnsddd
      421 pilekqlkrh nkvdnpeadh lsskwlpssp sgvakakmfk ldtgkmpvvy lepcavtrst
      481 vkiselpdnm lstsrkdkss mlaeleylpt yiensnetaf clgkesengl rkhspdlrvv
      541 qkypllkepq wkypdisdsi sterilddsk dsvgdslsgk edlgrkrttm lkiataakvv
      601 nanqnaspnv pgkrgrprkl klckagrppk ntgkslistk ntpvspgstf pdvkpdledv
      661 dgvlfvsfes kealdihavd gtteessslq asttndsgyr arisqlekel iedlktlrhk
      721 qvihpglqev glklnsvdpt msidlkylgv qlplapatsf pfwnltgtnp aspdagfpfv
      781 srtgktndft kikgwrgkfh sasasrnegg nsesslknrs afcsdkldey lenegklmet
      841 smgfssnapt spvvyqlptk stsyvrtlds vlkkqstisp stsyslkphs vppvsrkaks
      901 qnrqatfsgr tkssyksilp ypvspkqkys hvilgdkvtk nssgiisenq annfvvptld
      961 enifpkqisl rqaqqqqqqq qgsrppglsk sqvklmdled calwegkprt yiteeradvs
     1021 lttlltaqas lktkpihtii rkrappcnnd fcrlgcvcss lalekrqpah crrpdcmfgc
     1081 tclkrkvvlv kggsktkhfq rkaahrdpvf ydtlgeeare eeegireeee qlkekkkrkk
     1141 leyticetep eqpvrhyplw vkvegevdpe pvyiptpsvi epmkplllpq pevlsptvkg
     1201 klltgikspr sytpkpnpvi reedkdpvyl yfesmmtcar vrvyerkked qrqpsssssp
     1261 spsfqqqtsc hsspenhnna kepdseqqpl kqltcdledd sdklqekswk sscnegesss
     1321 tsymhqrspg gptklieiis dcnweedrnk ilsilsqhin snmpqslkvg sfiielasqr
     1381 ksrgeknppv yssrvkismp scqdqddmae ksgsetpdgp lspgkmedis pvqtdaldsv
     1441 rerlhggkgl pfyaglspag klvaykrkps sstsgliqvn gksypqakll lgqmgalhpa
     1501 nrlaayitgr lrpsvldlst lstviskvas nakvaasrkp rtllpstsns kmasssgtat
     1561 nrpgknlkaf vpakrpiaar pspggvftqf vmskvgalqq kipgvstpqt lagtqkfsir
     1621 pspvmvvtpv vssepvqvcs pvtaavtttt pqvflentta vtpmtaisdv etkettyssg
     1681 atttgvvevs etntstsvts tqstatvnlt kttgittpva svafpkslva spstitlpva
     1741 stastslvvv taaasssmvt tptsslgsvp iilsgingsp pvsqrpenaa qipvatpqvs
     1801 pntvkragpr lllipvqqgs ptlrpvsntq lqghrmvlqp vrspsgmnlf rhpngqivql
     1861 lplhqlrgsn tqpnlqpvmf rnpgsvmgir lpapskpset ppsstsssaf svmnpviqav
     1921 gsssavnvit qapsllssga sfvsqagtlt lrisppepqs fasktgsetk ityssggqpv
     1981 gtasliplqs gsfallqlpg qkpvpssilq hvaslqmkre sqnpdqkdet nsikreqetk
     2041 kvlqsegeav dpeanvikqn sgaatseetl ndsledrgdh ldeeclpeeg catvkpsehs
     2101 citgshtdqd ykdvneeyga rnrksskekv avlevrtise kasnktvqnl skvqhqklgd
     2161 vkveqqkgfd npeenssefp vtfkeeskfe lsgskvmeqq snlqpeakek ecgdslekdr
     2221 erwrkhlkgp ltrkcvgasq eckkeadeql iketktcqen sdvfqqeqgi sdllgksgit
     2281 edarvlktec dswsrisnps afsivprraa kssrgnghfq ghlllpgeqi qpkqekkggr
     2341 ssadftvldl eeddeddnek tddsideivd vvsdyqseev ddveknncve yieddeehvd
     2401 ietveelsee invahlktta ahtqsfkqps cthisadeka aersrkappi plklkpdyws
     2461 dklqkeaeaf ayyrrthtan errrrgemrd lfeklkitlg llhsskvsks liltrafsei
     2521 qgltdqadkl igqknlltrk rnilirkvss lsgkteevvl kkleyiyakq qaleaqkrkk
     2581 kmgsdefdis priskqqegs sassvdlgqm finnrrgkpl ilsrkkdqat entsplntph
     2641 tsanlvmtpq gqlltlkgpl fsgpvvavsp dllesdlkpq vagsavalpe nddlfmmpri
     2701 vnvtslateg glvdmggsky phevpdskps dhlkdtvrne dnsledkgri ssrgnrdgrv
     2761 tlgptqvfla nkdsgypqiv dvsnmqkaqe flpkkisgdm rgiqykwkes esrgervksk
     2821 dssfhklkmk dlkdssieme lrkvtsaiee aaldssellt nmededdtde tltsllneia
     2881 flnqqlndds vglaelpssm dtefpgdarr afiskvppgs ratfqvehlg tglkelpdvq
     2941 gesdsispll lhledddfse nekqlaepas epdvlkivid seikdsllsn kkaidggknt
     3001 sglpaepesv sspptlhmkt glensnstdt lwrpmpklap lglkvanpss dadgqslkvm
     3061 pclapiaakv gsvghkmnlt gndqegresk vmptlapvva klgnsgasps sagk
//
LOCUS       XP_047288234            3114 aa            linear   PRI 05-AUG-2025
DEFINITION  MAX gene-associated protein isoform X2 [Homo sapiens].
ACCESSION   XP_047288234
VERSION     XP_047288234.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432278.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..3114
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..3114
                     /product="MAX gene-associated protein isoform X2"
                     /calculated_mol_wt=341233
     Region          75..260
                     /region_name="T-box_MGA-like"
                     /note="DNA-binding domain of MAX gene-associated protein
                     and related T-box proteins; cd20195"
                     /db_xref="CDD:410321"
     Site            order(102..103,136,180,183,196..197,237..240,245,248..249,
                     252..258)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410321"
     Region          1041..1082
                     /region_name="MGA_dom"
                     /note="MGA, conserved domain; pfam16059"
                     /db_xref="CDD:464998"
     Region          <1519..1820
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          1710..>2032
                     /region_name="Atrophin-1"
                     /note="Atrophin-1 family; pfam03154"
                     /db_xref="CDD:460830"
     Region          2474..2538
                     /region_name="bHLHzip_MGA"
                     /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain
                     found in MAX gene-associated protein (MGA) and similar
                     proteins; cd18911"
                     /db_xref="CDD:381481"
     Site            order(2474,2476..2478,2480..2482,2484..2485,2489,
                     2508..2509)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381481"
     Site            order(2488,2491..2492,2494..2495,2498..2500,2510,
                     2513..2514,2517,2519..2521,2523..2524,2526..2527,2530,
                     2533..2534,2537..2538)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381481"
     CDS             1..3114
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /coded_by="XM_047432278.1:165..9509"
                     /db_xref="GeneID:23269"
                     /db_xref="HGNC:HGNC:14010"
                     /db_xref="MIM:616061"
ORIGIN      
        1 meekqqiila nqdggtvaga aptffvilkq pgngktdqgi lvtnqdacal assvsspvks
       61 kgkiclpadc tvggitvtld nnsmwnefyh rstemiltkq grrmfpycry witgldsnlk
      121 yilvmdispv dnhrykwngr wwepsgkaep hvlgrvfihp espstghywm hqpvsfyklk
      181 ltnntldqeg hiilhsmhry lprlhlvpae kaveviqlng pgvhtftfpq teffavtayq
      241 niqitqlkid ynpfakgfrd dglnnkpqrd gkqknssdqe gnnissssgh rvrltegqgs
      301 eiqpgdldpl srghetsgkg lektslnikr dflgfmdtds alsevpqlkq eisecliass
      361 feddsrvasp ldqngsfnvv ikeeplddyd yelgecpegv tvkqeetdee tdvysnsddd
      421 pilekqlkrh nkvdnpeadh lsskwlpssp sgvakakmfk ldtgkmpvvy lepcavtrst
      481 vkiselpdnm lstsrkdkss mlaeleylpt yiensnetaf clgkesengl rkhspdlrvv
      541 qkypllkepq wkypdisdsi sterilddsk dsvgdslsgk edlgrkrttm lkiataakvv
      601 nanqnaspnv pgkrgrprkl klckagrppk ntgkslistk ntpvspgstf pdvkpdledv
      661 dgvlfvsfes kealdihavd gtteessslq asttndsgyr arisqlekel iedlktlrhk
      721 qvihpglqev glklnsvdpt msidlkylgv qlplapatsf pfwnltgtnp aspdagfpfv
      781 srtgktndft kikgwrgkfh sasasrnegg nsesslknrs afcsdkldey lenegklmet
      841 smgfssnapt spvvyqlptk stsyvrtlds vlkkqstisp stsyslkphs vppvsrkaks
      901 qnrqatfsgr tkssyksilp ypvspkqkys hvilgdkvtk nssgiisenq annfvvptld
      961 enifpkqisl rqaqqqqqqq qgsrppglsk sqvklmdled calwegkprt yiteeradvs
     1021 lttlltaqas lktkpihtii rkrappcnnd fcrlgcvcss lalekrqpah crrpdcmfgc
     1081 tclkrkvvlv kggsktkhfq rkaahrdpvf ydtlgeeare eeegireeee qlkekkkrkk
     1141 leyticetep eqpvrhyplw vkvegevdpe pvyiptpsvi epmkplllpq pevlsptvkg
     1201 klltgikspr sytpkpnpvi reedkdpvyl yfesmmtcar vrvyerkked qrqpsssssp
     1261 spsfqqqtsc hsspenhnna kepdseqqpl kqltcdledd sdklqekswk sscnegesss
     1321 tsymhqrspg gptklieiis dcnweedrnk ilsilsqhin snmpqslkvg sfiielasqr
     1381 ksrgeknppv yssrvkismp scqdqddmae ksgsetpdgp lspgkmedis pvqtdaldsv
     1441 rerlhggkgl pfyaglspag klvaykrkps sstsgliqvn gksypqakll lgqmgalhpa
     1501 nrlaayitgr lrpsvldlst lstviskvas nakvaasrkp rtllpstsns kmasssgtat
     1561 nrpgknlkaf vpakrpiaar pspggvftqf vmskvgalqq kipgvstpqt lagtqkfsir
     1621 pspvmvvtpv vssepvqvcs pvtaavtttt pqvflentta vtpmtaisdv etkettyssg
     1681 atttgvvevs etntstsvts tqstatvnlt kttgittpva svafpkslva spstitlpva
     1741 stastslvvv taaasssmvt tptsslgsvp iilsgingsp pvsqrpenaa qipvatpqvs
     1801 pntvkragpr lllipvqqgs ptlrpvsntq lqghrmvlqp vrspsgmnlf rhpngqivql
     1861 lplhqlrgsn tqpnlqpvmf rnpgsvmgir lpapskpset ppsstsssaf svmnpviqav
     1921 gsssavnvit qapsllssga sfvsqagtlt lrisppepqs fasktgsetk ityssggqpv
     1981 gtasliplqs gsfallqlpg qkpvpssilq hvaslqmkre sqnpdqkdet nsikreqetk
     2041 kvlqsegeav dpeanvikqn sgaatseetl ndsledrgdh ldeeclpeeg catvkpsehs
     2101 citgshtdqd ykdvneeyga rnrksskekv avlevrtise kasnktvqnl skvqhqklgd
     2161 vkveqqkgfd npeenssefp vtfkeeskfe lsgskvmeqq snlqpeakek ecgdslekdr
     2221 erwrkhlkgp ltrkcvgasq eckkeadeql iketktcqen sdvfqqeqgi sdllgksgit
     2281 edarvlktec dswsrisnps afsivprraa kssrgnghfq ghlllpgeqi qpkqekkggr
     2341 ssadftvldl eeddeddnek tddsideivd vvsdyqseev ddveknncve yieddeehvd
     2401 ietveelsee invahlktta ahtqsfkqps cthisadeka aersrkappi plklkpdyws
     2461 dklqkeaeaf ayyrrthtan errrrgemrd lfeklkitlg llhsskvsks liltrafsei
     2521 qgltdqadkl igqknlltrk rnilirkvss lsgkteevvl kkleyiyakq qaleaqkrkk
     2581 kmgsdefdis priskqqegs sassvdlgqm finnrrgkpl ilsrkkdqat entsplntph
     2641 tsanlvmtpq gqlltlkgpl fsgpvvavsp dllesdlkpq vagsavalpe nddlfmmpri
     2701 vnvtslateg glvdmggsky phevpdskps dhlkdtvrne dnsledkgri ssrgnrdgrv
     2761 tlgptqvfla nkdsgypqiv dvsnmqkaqe flpkkisgdm rgiqykwkes esrgervksk
     2821 dssfhklkmk dlkdssieme lrkvtsaiee aaldssellt nmededdtde tltsllneia
     2881 flnqqlndds vglaelpssm dtefpgdarr afiskvppgs ratfqvehlg tglkelpdvq
     2941 gesdsispll lhledddfse nekqlaepas epdvlkivid seikdsllsn kkaidggknt
     3001 sglpaepesv sspptlhmkt glensnstdt lwrpmpklap lglkvanpss dadgqslkvm
     3061 pclapiaakv gsvghkmnlt gndqegresk vmptlapvva klgnsgasps sagk
//
LOCUS       XP_005254306            3066 aa            linear   PRI 05-AUG-2025
DEFINITION  MAX gene-associated protein isoform X3 [Homo sapiens].
ACCESSION   XP_005254306
VERSION     XP_005254306.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254249.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..3066
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..3066
                     /product="MAX gene-associated protein isoform X3"
                     /calculated_mol_wt=336129
     Region          75..260
                     /region_name="T-box_MGA-like"
                     /note="DNA-binding domain of MAX gene-associated protein
                     and related T-box proteins; cd20195"
                     /db_xref="CDD:410321"
     Site            order(102..103,136,180,183,196..197,237..240,245,248..249,
                     252..258)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410321"
     Region          1041..1082
                     /region_name="MGA_dom"
                     /note="MGA, conserved domain; pfam16059"
                     /db_xref="CDD:464998"
     Region          <1469..1771
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          1661..>1983
                     /region_name="Atrophin-1"
                     /note="Atrophin-1 family; pfam03154"
                     /db_xref="CDD:460830"
     Region          2426..2490
                     /region_name="bHLHzip_MGA"
                     /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain
                     found in MAX gene-associated protein (MGA) and similar
                     proteins; cd18911"
                     /db_xref="CDD:381481"
     Site            order(2426,2428..2430,2432..2434,2436..2437,2441,
                     2460..2461)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381481"
     Site            order(2440,2443..2444,2446..2447,2450..2452,2462,
                     2465..2466,2469,2471..2473,2475..2476,2478..2479,2482,
                     2485..2486,2489..2490)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381481"
     CDS             1..3066
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /coded_by="XM_005254249.4:189..9389"
                     /db_xref="GeneID:23269"
                     /db_xref="HGNC:HGNC:14010"
                     /db_xref="MIM:616061"
ORIGIN      
        1 meekqqiila nqdggtvaga aptffvilkq pgngktdqgi lvtnqdacal assvsspvks
       61 kgkiclpadc tvggitvtld nnsmwnefyh rstemiltkq grrmfpycry witgldsnlk
      121 yilvmdispv dnhrykwngr wwepsgkaep hvlgrvfihp espstghywm hqpvsfyklk
      181 ltnntldqeg hiilhsmhry lprlhlvpae kaveviqlng pgvhtftfpq teffavtayq
      241 niqitqlkid ynpfakgfrd dglnnkpqrd gkqknssdqe gnnissssgh rvrltegqgs
      301 eiqpgdldpl srghetsgkg lektslnikr dflgfmdtds alsevpqlkq eisecliass
      361 feddsrvasp ldqngsfnvv ikeeplddyd yelgecpegv tvkqeetdee tdvysnsddd
      421 pilekqlkrh nkvdnpeadh lsskwlpssp sgvakakmfk ldtgkmpvvy lepcavtrst
      481 vkiselpdnm lstsrkdkss mlaeleylpt yiensnetaf clgkesengl rkhspdlrvv
      541 qkypllkepq wkypdisdsi sterilddsk dsvgdslsgk edlgrkrttm lkiataakvv
      601 nanqnaspnv pgkrgrprkl klckagrppk ntgkslistk ntpvspgstf pdvkpdledv
      661 dgvlfvsfes kealdihavd gtteessslq asttndsgyr arisqlekel iedlktlrhk
      721 qvihpglqev glklnsvdpt msidlkylgv qlplapatsf pfwnltgtnp aspdagfpfv
      781 srtgktndft kikgwrgkfh sasasrnegg nsesslknrs afcsdkldey lenegklmet
      841 smgfssnapt spvvyqlptk stsyvrtlds vlkkqstisp stsyslkphs vppvsrkaks
      901 qnrqatfsgr tkssyksilp ypvspkqkys hvilgdkvtk nssgiisenq annfvvptld
      961 enifpkqisl rqaqqqqqqq qgsrppglsk sqvklmdled calwegkprt yiteeradvs
     1021 lttlltaqas lktkpihtii rkrappcnnd fcrlgcvcss lalekrqpah crrpdcmfgc
     1081 tclkrkvvlv kggsktkhfq rkaahrdpvf ydtlgeeare eeegireeee qlkekkkrkk
     1141 leyticetep eqpvrhyplw vkvegevdpe pvyiptpsvi epmkplllpq pevlsptvkg
     1201 klltgikspr sytpkpnpvi reedkdpvyl yfesmmtcar vrvyerkked qrqpsssssp
     1261 spsfqqqtsc hsspenhnna kepdseqqpl kqltcdledd sdklqekswk sscnegesss
     1321 tsymhqrspg gptklieiis dcnweedrnk ilsilsqhin snmpqslkvg sfiielasqr
     1381 ksrgeknppv yssrvkismp scqdqddmae ksgsetpdgp lspgkmedis pvqtdaldsv
     1441 rerlhggkgl pfyaglspag klvaykrkps sstsgliqva snakvaasrk prtllpstsn
     1501 skmasssgta tnrpgknlka fvpakrpiaa rpspggvftq fvmskvgalq qkipgvstpq
     1561 tlagtqkfsi rpspvmvvtp vvssepvqvc spvtaavttt tpqvflentt avtpmtaisd
     1621 vetkettyss gatttgvvev setntstsvt stqstatvnl tkttgittpv asvafpkslv
     1681 aspstitlpv astastslvv vtaaasssmv ttptsslgsv piilsgings ppvsqrpena
     1741 aqipvatpqv spntvkragp rlllipvqqg sptlrpvsnt qlqghrmvlq pvrspsgmnl
     1801 frhpngqivq llplhqlrgs ntqpnlqpvm frnpgsvmgi rlpapskpse tppsstsssa
     1861 fsvmnpviqa vgsssavnvi tqapsllssg asfvsqagtl tlrisppepq sfasktgset
     1921 kityssggqp vgtasliplq sgsfallqlp gqkpvpssil qhvaslqmkr esqnpdqkde
     1981 tnsikreqet kkvlqsegea vdpeanvikq nsgaatseet lndsledrgd hldeeclpee
     2041 gcatvkpseh scitgshtdq dykdvneeyg arnrksskek vavlevrtis ekasnktvqn
     2101 lskvqhqklg dvkveqqkgf dnpeenssef pvtfkeeskf elsgskvmeq qsnlqpeake
     2161 kecgdslekd rerwrkhlkg pltrkcvgas qeckkeadeq liketktcqe nsdvfqqeqg
     2221 isdllgksgi tedarvlkte cdswsrisnp safsivprra akssrgnghf qghlllpgeq
     2281 iqpkqekkgg rssadftvld leeddeddne ktddsideiv dvvsdyqsee vddvekvnnc
     2341 veyieddeeh vdietveels eeinvahlkt taahtqsfkq pscthisade kaaersrkap
     2401 piplklkpdy wsdklqkeae afayyrrtht anerrrrgem rdlfeklkit lgllhsskvs
     2461 ksliltrafs eiqgltdqad kligqknllt rkrnilirkv sslsgkteev vlkkleyiya
     2521 kqqaleaqkr kkkmgsdefd ispriskqqe gssassvdlg qmfinnrrgk plilsrkkdq
     2581 atentsplnt phtsanlvmt pqgqlltlkg plfsgpvvav spdllesdlk pqvagsaval
     2641 penddlfmmp rivnvtslat egglvdmggs kyphevpdsk psdhlkdtvr nednsledkg
     2701 rissrgnrdg rvtlgptqvf lankdsgypq ivdvsnmqka qeflpkkisg dmrgiqykwk
     2761 esesrgervk skdssfhklk mkdlkdssie melrkvtsai eeaaldssel ltnmededdt
     2821 detltsllne iaflnqqlnd dsvglaelps smdtefpgda rrafiskvpp gsratfqveh
     2881 lgtglkelpd vqgesdsisp lllhledddf senekqlaep asepdvlkiv idseikdsll
     2941 snkkaidggk ntsglpaepe svsspptlhm ktglensnst dtlwrpmpkl aplglkvanp
     3001 ssdadgqslk vmpclapiaa kvgsvghkmn ltgndqegre skvmptlapv vaklgnsgas
     3061 pssagk
//
LOCUS       XP_047288235            3066 aa            linear   PRI 05-AUG-2025
DEFINITION  MAX gene-associated protein isoform X3 [Homo sapiens].
ACCESSION   XP_047288235
VERSION     XP_047288235.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432279.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..3066
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..3066
                     /product="MAX gene-associated protein isoform X3"
                     /calculated_mol_wt=336129
     Region          75..260
                     /region_name="T-box_MGA-like"
                     /note="DNA-binding domain of MAX gene-associated protein
                     and related T-box proteins; cd20195"
                     /db_xref="CDD:410321"
     Site            order(102..103,136,180,183,196..197,237..240,245,248..249,
                     252..258)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410321"
     Region          1041..1082
                     /region_name="MGA_dom"
                     /note="MGA, conserved domain; pfam16059"
                     /db_xref="CDD:464998"
     Region          <1469..1771
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          1661..>1983
                     /region_name="Atrophin-1"
                     /note="Atrophin-1 family; pfam03154"
                     /db_xref="CDD:460830"
     Region          2426..2490
                     /region_name="bHLHzip_MGA"
                     /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain
                     found in MAX gene-associated protein (MGA) and similar
                     proteins; cd18911"
                     /db_xref="CDD:381481"
     Site            order(2426,2428..2430,2432..2434,2436..2437,2441,
                     2460..2461)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381481"
     Site            order(2440,2443..2444,2446..2447,2450..2452,2462,
                     2465..2466,2469,2471..2473,2475..2476,2478..2479,2482,
                     2485..2486,2489..2490)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381481"
     CDS             1..3066
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /coded_by="XM_047432279.1:143..9343"
                     /db_xref="GeneID:23269"
                     /db_xref="HGNC:HGNC:14010"
                     /db_xref="MIM:616061"
ORIGIN      
        1 meekqqiila nqdggtvaga aptffvilkq pgngktdqgi lvtnqdacal assvsspvks
       61 kgkiclpadc tvggitvtld nnsmwnefyh rstemiltkq grrmfpycry witgldsnlk
      121 yilvmdispv dnhrykwngr wwepsgkaep hvlgrvfihp espstghywm hqpvsfyklk
      181 ltnntldqeg hiilhsmhry lprlhlvpae kaveviqlng pgvhtftfpq teffavtayq
      241 niqitqlkid ynpfakgfrd dglnnkpqrd gkqknssdqe gnnissssgh rvrltegqgs
      301 eiqpgdldpl srghetsgkg lektslnikr dflgfmdtds alsevpqlkq eisecliass
      361 feddsrvasp ldqngsfnvv ikeeplddyd yelgecpegv tvkqeetdee tdvysnsddd
      421 pilekqlkrh nkvdnpeadh lsskwlpssp sgvakakmfk ldtgkmpvvy lepcavtrst
      481 vkiselpdnm lstsrkdkss mlaeleylpt yiensnetaf clgkesengl rkhspdlrvv
      541 qkypllkepq wkypdisdsi sterilddsk dsvgdslsgk edlgrkrttm lkiataakvv
      601 nanqnaspnv pgkrgrprkl klckagrppk ntgkslistk ntpvspgstf pdvkpdledv
      661 dgvlfvsfes kealdihavd gtteessslq asttndsgyr arisqlekel iedlktlrhk
      721 qvihpglqev glklnsvdpt msidlkylgv qlplapatsf pfwnltgtnp aspdagfpfv
      781 srtgktndft kikgwrgkfh sasasrnegg nsesslknrs afcsdkldey lenegklmet
      841 smgfssnapt spvvyqlptk stsyvrtlds vlkkqstisp stsyslkphs vppvsrkaks
      901 qnrqatfsgr tkssyksilp ypvspkqkys hvilgdkvtk nssgiisenq annfvvptld
      961 enifpkqisl rqaqqqqqqq qgsrppglsk sqvklmdled calwegkprt yiteeradvs
     1021 lttlltaqas lktkpihtii rkrappcnnd fcrlgcvcss lalekrqpah crrpdcmfgc
     1081 tclkrkvvlv kggsktkhfq rkaahrdpvf ydtlgeeare eeegireeee qlkekkkrkk
     1141 leyticetep eqpvrhyplw vkvegevdpe pvyiptpsvi epmkplllpq pevlsptvkg
     1201 klltgikspr sytpkpnpvi reedkdpvyl yfesmmtcar vrvyerkked qrqpsssssp
     1261 spsfqqqtsc hsspenhnna kepdseqqpl kqltcdledd sdklqekswk sscnegesss
     1321 tsymhqrspg gptklieiis dcnweedrnk ilsilsqhin snmpqslkvg sfiielasqr
     1381 ksrgeknppv yssrvkismp scqdqddmae ksgsetpdgp lspgkmedis pvqtdaldsv
     1441 rerlhggkgl pfyaglspag klvaykrkps sstsgliqva snakvaasrk prtllpstsn
     1501 skmasssgta tnrpgknlka fvpakrpiaa rpspggvftq fvmskvgalq qkipgvstpq
     1561 tlagtqkfsi rpspvmvvtp vvssepvqvc spvtaavttt tpqvflentt avtpmtaisd
     1621 vetkettyss gatttgvvev setntstsvt stqstatvnl tkttgittpv asvafpkslv
     1681 aspstitlpv astastslvv vtaaasssmv ttptsslgsv piilsgings ppvsqrpena
     1741 aqipvatpqv spntvkragp rlllipvqqg sptlrpvsnt qlqghrmvlq pvrspsgmnl
     1801 frhpngqivq llplhqlrgs ntqpnlqpvm frnpgsvmgi rlpapskpse tppsstsssa
     1861 fsvmnpviqa vgsssavnvi tqapsllssg asfvsqagtl tlrisppepq sfasktgset
     1921 kityssggqp vgtasliplq sgsfallqlp gqkpvpssil qhvaslqmkr esqnpdqkde
     1981 tnsikreqet kkvlqsegea vdpeanvikq nsgaatseet lndsledrgd hldeeclpee
     2041 gcatvkpseh scitgshtdq dykdvneeyg arnrksskek vavlevrtis ekasnktvqn
     2101 lskvqhqklg dvkveqqkgf dnpeenssef pvtfkeeskf elsgskvmeq qsnlqpeake
     2161 kecgdslekd rerwrkhlkg pltrkcvgas qeckkeadeq liketktcqe nsdvfqqeqg
     2221 isdllgksgi tedarvlkte cdswsrisnp safsivprra akssrgnghf qghlllpgeq
     2281 iqpkqekkgg rssadftvld leeddeddne ktddsideiv dvvsdyqsee vddvekvnnc
     2341 veyieddeeh vdietveels eeinvahlkt taahtqsfkq pscthisade kaaersrkap
     2401 piplklkpdy wsdklqkeae afayyrrtht anerrrrgem rdlfeklkit lgllhsskvs
     2461 ksliltrafs eiqgltdqad kligqknllt rkrnilirkv sslsgkteev vlkkleyiya
     2521 kqqaleaqkr kkkmgsdefd ispriskqqe gssassvdlg qmfinnrrgk plilsrkkdq
     2581 atentsplnt phtsanlvmt pqgqlltlkg plfsgpvvav spdllesdlk pqvagsaval
     2641 penddlfmmp rivnvtslat egglvdmggs kyphevpdsk psdhlkdtvr nednsledkg
     2701 rissrgnrdg rvtlgptqvf lankdsgypq ivdvsnmqka qeflpkkisg dmrgiqykwk
     2761 esesrgervk skdssfhklk mkdlkdssie melrkvtsai eeaaldssel ltnmededdt
     2821 detltsllne iaflnqqlnd dsvglaelps smdtefpgda rrafiskvpp gsratfqveh
     2881 lgtglkelpd vqgesdsisp lllhledddf senekqlaep asepdvlkiv idseikdsll
     2941 snkkaidggk ntsglpaepe svsspptlhm ktglensnst dtlwrpmpkl aplglkvanp
     3001 ssdadgqslk vmpclapiaa kvgsvghkmn ltgndqegre skvmptlapv vaklgnsgas
     3061 pssagk
//
LOCUS       XP_047288236            3065 aa            linear   PRI 05-AUG-2025
DEFINITION  MAX gene-associated protein isoform X4 [Homo sapiens].
ACCESSION   XP_047288236
VERSION     XP_047288236.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432280.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..3065
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..3065
                     /product="MAX gene-associated protein isoform X4"
                     /calculated_mol_wt=336030
     Region          75..260
                     /region_name="T-box_MGA-like"
                     /note="DNA-binding domain of MAX gene-associated protein
                     and related T-box proteins; cd20195"
                     /db_xref="CDD:410321"
     Site            order(102..103,136,180,183,196..197,237..240,245,248..249,
                     252..258)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410321"
     Region          1041..1082
                     /region_name="MGA_dom"
                     /note="MGA, conserved domain; pfam16059"
                     /db_xref="CDD:464998"
     Region          <1469..1771
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          1661..>1983
                     /region_name="Atrophin-1"
                     /note="Atrophin-1 family; pfam03154"
                     /db_xref="CDD:460830"
     Region          2425..2489
                     /region_name="bHLHzip_MGA"
                     /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain
                     found in MAX gene-associated protein (MGA) and similar
                     proteins; cd18911"
                     /db_xref="CDD:381481"
     Site            order(2425,2427..2429,2431..2433,2435..2436,2440,
                     2459..2460)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381481"
     Site            order(2439,2442..2443,2445..2446,2449..2451,2461,
                     2464..2465,2468,2470..2472,2474..2475,2477..2478,2481,
                     2484..2485,2488..2489)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381481"
     CDS             1..3065
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /coded_by="XM_047432280.1:143..9340"
                     /db_xref="GeneID:23269"
                     /db_xref="HGNC:HGNC:14010"
                     /db_xref="MIM:616061"
ORIGIN      
        1 meekqqiila nqdggtvaga aptffvilkq pgngktdqgi lvtnqdacal assvsspvks
       61 kgkiclpadc tvggitvtld nnsmwnefyh rstemiltkq grrmfpycry witgldsnlk
      121 yilvmdispv dnhrykwngr wwepsgkaep hvlgrvfihp espstghywm hqpvsfyklk
      181 ltnntldqeg hiilhsmhry lprlhlvpae kaveviqlng pgvhtftfpq teffavtayq
      241 niqitqlkid ynpfakgfrd dglnnkpqrd gkqknssdqe gnnissssgh rvrltegqgs
      301 eiqpgdldpl srghetsgkg lektslnikr dflgfmdtds alsevpqlkq eisecliass
      361 feddsrvasp ldqngsfnvv ikeeplddyd yelgecpegv tvkqeetdee tdvysnsddd
      421 pilekqlkrh nkvdnpeadh lsskwlpssp sgvakakmfk ldtgkmpvvy lepcavtrst
      481 vkiselpdnm lstsrkdkss mlaeleylpt yiensnetaf clgkesengl rkhspdlrvv
      541 qkypllkepq wkypdisdsi sterilddsk dsvgdslsgk edlgrkrttm lkiataakvv
      601 nanqnaspnv pgkrgrprkl klckagrppk ntgkslistk ntpvspgstf pdvkpdledv
      661 dgvlfvsfes kealdihavd gtteessslq asttndsgyr arisqlekel iedlktlrhk
      721 qvihpglqev glklnsvdpt msidlkylgv qlplapatsf pfwnltgtnp aspdagfpfv
      781 srtgktndft kikgwrgkfh sasasrnegg nsesslknrs afcsdkldey lenegklmet
      841 smgfssnapt spvvyqlptk stsyvrtlds vlkkqstisp stsyslkphs vppvsrkaks
      901 qnrqatfsgr tkssyksilp ypvspkqkys hvilgdkvtk nssgiisenq annfvvptld
      961 enifpkqisl rqaqqqqqqq qgsrppglsk sqvklmdled calwegkprt yiteeradvs
     1021 lttlltaqas lktkpihtii rkrappcnnd fcrlgcvcss lalekrqpah crrpdcmfgc
     1081 tclkrkvvlv kggsktkhfq rkaahrdpvf ydtlgeeare eeegireeee qlkekkkrkk
     1141 leyticetep eqpvrhyplw vkvegevdpe pvyiptpsvi epmkplllpq pevlsptvkg
     1201 klltgikspr sytpkpnpvi reedkdpvyl yfesmmtcar vrvyerkked qrqpsssssp
     1261 spsfqqqtsc hsspenhnna kepdseqqpl kqltcdledd sdklqekswk sscnegesss
     1321 tsymhqrspg gptklieiis dcnweedrnk ilsilsqhin snmpqslkvg sfiielasqr
     1381 ksrgeknppv yssrvkismp scqdqddmae ksgsetpdgp lspgkmedis pvqtdaldsv
     1441 rerlhggkgl pfyaglspag klvaykrkps sstsgliqva snakvaasrk prtllpstsn
     1501 skmasssgta tnrpgknlka fvpakrpiaa rpspggvftq fvmskvgalq qkipgvstpq
     1561 tlagtqkfsi rpspvmvvtp vvssepvqvc spvtaavttt tpqvflentt avtpmtaisd
     1621 vetkettyss gatttgvvev setntstsvt stqstatvnl tkttgittpv asvafpkslv
     1681 aspstitlpv astastslvv vtaaasssmv ttptsslgsv piilsgings ppvsqrpena
     1741 aqipvatpqv spntvkragp rlllipvqqg sptlrpvsnt qlqghrmvlq pvrspsgmnl
     1801 frhpngqivq llplhqlrgs ntqpnlqpvm frnpgsvmgi rlpapskpse tppsstsssa
     1861 fsvmnpviqa vgsssavnvi tqapsllssg asfvsqagtl tlrisppepq sfasktgset
     1921 kityssggqp vgtasliplq sgsfallqlp gqkpvpssil qhvaslqmkr esqnpdqkde
     1981 tnsikreqet kkvlqsegea vdpeanvikq nsgaatseet lndsledrgd hldeeclpee
     2041 gcatvkpseh scitgshtdq dykdvneeyg arnrksskek vavlevrtis ekasnktvqn
     2101 lskvqhqklg dvkveqqkgf dnpeenssef pvtfkeeskf elsgskvmeq qsnlqpeake
     2161 kecgdslekd rerwrkhlkg pltrkcvgas qeckkeadeq liketktcqe nsdvfqqeqg
     2221 isdllgksgi tedarvlkte cdswsrisnp safsivprra akssrgnghf qghlllpgeq
     2281 iqpkqekkgg rssadftvld leeddeddne ktddsideiv dvvsdyqsee vddveknncv
     2341 eyieddeehv dietveelse einvahlktt aahtqsfkqp scthisadek aaersrkapp
     2401 iplklkpdyw sdklqkeaea fayyrrthta nerrrrgemr dlfeklkitl gllhsskvsk
     2461 sliltrafse iqgltdqadk ligqknlltr krnilirkvs slsgkteevv lkkleyiyak
     2521 qqaleaqkrk kkmgsdefdi spriskqqeg ssassvdlgq mfinnrrgkp lilsrkkdqa
     2581 tentsplntp htsanlvmtp qgqlltlkgp lfsgpvvavs pdllesdlkp qvagsavalp
     2641 enddlfmmpr ivnvtslate gglvdmggsk yphevpdskp sdhlkdtvrn ednsledkgr
     2701 issrgnrdgr vtlgptqvfl ankdsgypqi vdvsnmqkaq eflpkkisgd mrgiqykwke
     2761 sesrgervks kdssfhklkm kdlkdssiem elrkvtsaie eaaldssell tnmededdtd
     2821 etltsllnei aflnqqlndd svglaelpss mdtefpgdar rafiskvppg sratfqvehl
     2881 gtglkelpdv qgesdsispl llhledddfs enekqlaepa sepdvlkivi dseikdslls
     2941 nkkaidggkn tsglpaepes vsspptlhmk tglensnstd tlwrpmpkla plglkvanps
     3001 sdadgqslkv mpclapiaak vgsvghkmnl tgndqegres kvmptlapvv aklgnsgasp
     3061 ssagk
//
LOCUS       XP_011519699            3005 aa            linear   PRI 05-AUG-2025
DEFINITION  MAX gene-associated protein isoform X5 [Homo sapiens].
ACCESSION   XP_011519699
VERSION     XP_011519699.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521397.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..3005
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..3005
                     /product="MAX gene-associated protein isoform X5"
                     /calculated_mol_wt=329614
     Region          75..260
                     /region_name="T-box_MGA-like"
                     /note="DNA-binding domain of MAX gene-associated protein
                     and related T-box proteins; cd20195"
                     /db_xref="CDD:410321"
     Site            order(102..103,136,180,183,196..197,237..240,245,248..249,
                     252..258)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410321"
     Region          1041..1082
                     /region_name="MGA_dom"
                     /note="MGA, conserved domain; pfam16059"
                     /db_xref="CDD:464998"
     Region          <1409..1710
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          1600..>1922
                     /region_name="Atrophin-1"
                     /note="Atrophin-1 family; pfam03154"
                     /db_xref="CDD:460830"
     Region          2365..2429
                     /region_name="bHLHzip_MGA"
                     /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain
                     found in MAX gene-associated protein (MGA) and similar
                     proteins; cd18911"
                     /db_xref="CDD:381481"
     Site            order(2365,2367..2369,2371..2373,2375..2376,2380,
                     2399..2400)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381481"
     Site            order(2379,2382..2383,2385..2386,2389..2391,2401,
                     2404..2405,2408,2410..2412,2414..2415,2417..2418,2421,
                     2424..2425,2428..2429)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381481"
     CDS             1..3005
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /coded_by="XM_011521397.4:189..9206"
                     /db_xref="GeneID:23269"
                     /db_xref="HGNC:HGNC:14010"
                     /db_xref="MIM:616061"
ORIGIN      
        1 meekqqiila nqdggtvaga aptffvilkq pgngktdqgi lvtnqdacal assvsspvks
       61 kgkiclpadc tvggitvtld nnsmwnefyh rstemiltkq grrmfpycry witgldsnlk
      121 yilvmdispv dnhrykwngr wwepsgkaep hvlgrvfihp espstghywm hqpvsfyklk
      181 ltnntldqeg hiilhsmhry lprlhlvpae kaveviqlng pgvhtftfpq teffavtayq
      241 niqitqlkid ynpfakgfrd dglnnkpqrd gkqknssdqe gnnissssgh rvrltegqgs
      301 eiqpgdldpl srghetsgkg lektslnikr dflgfmdtds alsevpqlkq eisecliass
      361 feddsrvasp ldqngsfnvv ikeeplddyd yelgecpegv tvkqeetdee tdvysnsddd
      421 pilekqlkrh nkvdnpeadh lsskwlpssp sgvakakmfk ldtgkmpvvy lepcavtrst
      481 vkiselpdnm lstsrkdkss mlaeleylpt yiensnetaf clgkesengl rkhspdlrvv
      541 qkypllkepq wkypdisdsi sterilddsk dsvgdslsgk edlgrkrttm lkiataakvv
      601 nanqnaspnv pgkrgrprkl klckagrppk ntgkslistk ntpvspgstf pdvkpdledv
      661 dgvlfvsfes kealdihavd gtteessslq asttndsgyr arisqlekel iedlktlrhk
      721 qvihpglqev glklnsvdpt msidlkylgv qlplapatsf pfwnltgtnp aspdagfpfv
      781 srtgktndft kikgwrgkfh sasasrnegg nsesslknrs afcsdkldey lenegklmet
      841 smgfssnapt spvvyqlptk stsyvrtlds vlkkqstisp stsyslkphs vppvsrkaks
      901 qnrqatfsgr tkssyksilp ypvspkqkys hvilgdkvtk nssgiisenq annfvvptld
      961 enifpkqisl rqaqqqqqqq qgsrppglsk sqvklmdled calwegkprt yiteeradvs
     1021 lttlltaqas lktkpihtii rkrappcnnd fcrlgcvcss lalekrqpah crrpdcmfgc
     1081 tclkrkvvlv kggsktkhfq rkaahrdpvf ydtlgeeare eeegireeee qlkekkkrkk
     1141 leyticetep eqpvrhyplw vkvegevdpe pvyiptpsvi epmkplllpq pevlsptvkg
     1201 klltgikspr sytpkpnpvi reedkdpvyl yfesmmtcar vrvyerkked qrqpsssssp
     1261 spsfqqqtsc hsspenhnna kepdseqqpl kqltcdledd sdklqekswk sscnegesss
     1321 tsymhqrspg gptklieiis dcnweedrnk ilsilsqhin snmpqslkvn gksypqakll
     1381 lgqmgalhpa nrlaayitgr lrpsvldlst lstviskvas nakvaasrkp rtllpstsns
     1441 kmasssgtat nrpgknlkaf vpakrpiaar pspggvftqf vmskvgalqq kipgvstpqt
     1501 lagtqkfsir pspvmvvtpv vssepvqvcs pvtaavtttt pqvflentta vtpmtaisdv
     1561 etkettyssg atttgvvevs etntstsvts tqstatvnlt kttgittpva svafpkslva
     1621 spstitlpva stastslvvv taaasssmvt tptsslgsvp iilsgingsp pvsqrpenaa
     1681 qipvatpqvs pntvkragpr lllipvqqgs ptlrpvsntq lqghrmvlqp vrspsgmnlf
     1741 rhpngqivql lplhqlrgsn tqpnlqpvmf rnpgsvmgir lpapskpset ppsstsssaf
     1801 svmnpviqav gsssavnvit qapsllssga sfvsqagtlt lrisppepqs fasktgsetk
     1861 ityssggqpv gtasliplqs gsfallqlpg qkpvpssilq hvaslqmkre sqnpdqkdet
     1921 nsikreqetk kvlqsegeav dpeanvikqn sgaatseetl ndsledrgdh ldeeclpeeg
     1981 catvkpsehs citgshtdqd ykdvneeyga rnrksskekv avlevrtise kasnktvqnl
     2041 skvqhqklgd vkveqqkgfd npeenssefp vtfkeeskfe lsgskvmeqq snlqpeakek
     2101 ecgdslekdr erwrkhlkgp ltrkcvgasq eckkeadeql iketktcqen sdvfqqeqgi
     2161 sdllgksgit edarvlktec dswsrisnps afsivprraa kssrgnghfq ghlllpgeqi
     2221 qpkqekkggr ssadftvldl eeddeddnek tddsideivd vvsdyqseev ddvekvnncv
     2281 eyieddeehv dietveelse einvahlktt aahtqsfkqp scthisadek aaersrkapp
     2341 iplklkpdyw sdklqkeaea fayyrrthta nerrrrgemr dlfeklkitl gllhsskvsk
     2401 sliltrafse iqgltdqadk ligqknlltr krnilirkvs slsgkteevv lkkleyiyak
     2461 qqaleaqkrk kkmgsdefdi spriskqqeg ssassvdlgq mfinnrrgkp lilsrkkdqa
     2521 tentsplntp htsanlvmtp qgqlltlkgp lfsgpvvavs pdllesdlkp qvagsavalp
     2581 enddlfmmpr ivnvtslate gglvdmggsk yphevpdskp sdhlkdtvrn ednsledkgr
     2641 issrgnrdgr vtlgptqvfl ankdsgypqi vdvsnmqkaq eflpkkisgd mrgiqykwke
     2701 sesrgervks kdssfhklkm kdlkdssiem elrkvtsaie eaaldssell tnmededdtd
     2761 etltsllnei aflnqqlndd svglaelpss mdtefpgdar rafiskvppg sratfqvehl
     2821 gtglkelpdv qgesdsispl llhledddfs enekqlaepa sepdvlkivi dseikdslls
     2881 nkkaidggkn tsglpaepes vsspptlhmk tglensnstd tlwrpmpkla plglkvanps
     2941 sdadgqslkv mpclapiaak vgsvghkmnl tgndqegres kvmptlapvv aklgnsgasp
     3001 ssagk
//
LOCUS       XP_011519700            3004 aa            linear   PRI 05-AUG-2025
DEFINITION  MAX gene-associated protein isoform X6 [Homo sapiens].
ACCESSION   XP_011519700
VERSION     XP_011519700.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521398.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..3004
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..3004
                     /product="MAX gene-associated protein isoform X6"
                     /calculated_mol_wt=329515
     Region          75..260
                     /region_name="T-box_MGA-like"
                     /note="DNA-binding domain of MAX gene-associated protein
                     and related T-box proteins; cd20195"
                     /db_xref="CDD:410321"
     Site            order(102..103,136,180,183,196..197,237..240,245,248..249,
                     252..258)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410321"
     Region          1041..1082
                     /region_name="MGA_dom"
                     /note="MGA, conserved domain; pfam16059"
                     /db_xref="CDD:464998"
     Region          <1409..1710
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          1600..>1922
                     /region_name="Atrophin-1"
                     /note="Atrophin-1 family; pfam03154"
                     /db_xref="CDD:460830"
     Region          2364..2428
                     /region_name="bHLHzip_MGA"
                     /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain
                     found in MAX gene-associated protein (MGA) and similar
                     proteins; cd18911"
                     /db_xref="CDD:381481"
     Site            order(2364,2366..2368,2370..2372,2374..2375,2379,
                     2398..2399)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381481"
     Site            order(2378,2381..2382,2384..2385,2388..2390,2400,
                     2403..2404,2407,2409..2411,2413..2414,2416..2417,2420,
                     2423..2424,2427..2428)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381481"
     CDS             1..3004
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /coded_by="XM_011521398.4:189..9203"
                     /db_xref="GeneID:23269"
                     /db_xref="HGNC:HGNC:14010"
                     /db_xref="MIM:616061"
ORIGIN      
        1 meekqqiila nqdggtvaga aptffvilkq pgngktdqgi lvtnqdacal assvsspvks
       61 kgkiclpadc tvggitvtld nnsmwnefyh rstemiltkq grrmfpycry witgldsnlk
      121 yilvmdispv dnhrykwngr wwepsgkaep hvlgrvfihp espstghywm hqpvsfyklk
      181 ltnntldqeg hiilhsmhry lprlhlvpae kaveviqlng pgvhtftfpq teffavtayq
      241 niqitqlkid ynpfakgfrd dglnnkpqrd gkqknssdqe gnnissssgh rvrltegqgs
      301 eiqpgdldpl srghetsgkg lektslnikr dflgfmdtds alsevpqlkq eisecliass
      361 feddsrvasp ldqngsfnvv ikeeplddyd yelgecpegv tvkqeetdee tdvysnsddd
      421 pilekqlkrh nkvdnpeadh lsskwlpssp sgvakakmfk ldtgkmpvvy lepcavtrst
      481 vkiselpdnm lstsrkdkss mlaeleylpt yiensnetaf clgkesengl rkhspdlrvv
      541 qkypllkepq wkypdisdsi sterilddsk dsvgdslsgk edlgrkrttm lkiataakvv
      601 nanqnaspnv pgkrgrprkl klckagrppk ntgkslistk ntpvspgstf pdvkpdledv
      661 dgvlfvsfes kealdihavd gtteessslq asttndsgyr arisqlekel iedlktlrhk
      721 qvihpglqev glklnsvdpt msidlkylgv qlplapatsf pfwnltgtnp aspdagfpfv
      781 srtgktndft kikgwrgkfh sasasrnegg nsesslknrs afcsdkldey lenegklmet
      841 smgfssnapt spvvyqlptk stsyvrtlds vlkkqstisp stsyslkphs vppvsrkaks
      901 qnrqatfsgr tkssyksilp ypvspkqkys hvilgdkvtk nssgiisenq annfvvptld
      961 enifpkqisl rqaqqqqqqq qgsrppglsk sqvklmdled calwegkprt yiteeradvs
     1021 lttlltaqas lktkpihtii rkrappcnnd fcrlgcvcss lalekrqpah crrpdcmfgc
     1081 tclkrkvvlv kggsktkhfq rkaahrdpvf ydtlgeeare eeegireeee qlkekkkrkk
     1141 leyticetep eqpvrhyplw vkvegevdpe pvyiptpsvi epmkplllpq pevlsptvkg
     1201 klltgikspr sytpkpnpvi reedkdpvyl yfesmmtcar vrvyerkked qrqpsssssp
     1261 spsfqqqtsc hsspenhnna kepdseqqpl kqltcdledd sdklqekswk sscnegesss
     1321 tsymhqrspg gptklieiis dcnweedrnk ilsilsqhin snmpqslkvn gksypqakll
     1381 lgqmgalhpa nrlaayitgr lrpsvldlst lstviskvas nakvaasrkp rtllpstsns
     1441 kmasssgtat nrpgknlkaf vpakrpiaar pspggvftqf vmskvgalqq kipgvstpqt
     1501 lagtqkfsir pspvmvvtpv vssepvqvcs pvtaavtttt pqvflentta vtpmtaisdv
     1561 etkettyssg atttgvvevs etntstsvts tqstatvnlt kttgittpva svafpkslva
     1621 spstitlpva stastslvvv taaasssmvt tptsslgsvp iilsgingsp pvsqrpenaa
     1681 qipvatpqvs pntvkragpr lllipvqqgs ptlrpvsntq lqghrmvlqp vrspsgmnlf
     1741 rhpngqivql lplhqlrgsn tqpnlqpvmf rnpgsvmgir lpapskpset ppsstsssaf
     1801 svmnpviqav gsssavnvit qapsllssga sfvsqagtlt lrisppepqs fasktgsetk
     1861 ityssggqpv gtasliplqs gsfallqlpg qkpvpssilq hvaslqmkre sqnpdqkdet
     1921 nsikreqetk kvlqsegeav dpeanvikqn sgaatseetl ndsledrgdh ldeeclpeeg
     1981 catvkpsehs citgshtdqd ykdvneeyga rnrksskekv avlevrtise kasnktvqnl
     2041 skvqhqklgd vkveqqkgfd npeenssefp vtfkeeskfe lsgskvmeqq snlqpeakek
     2101 ecgdslekdr erwrkhlkgp ltrkcvgasq eckkeadeql iketktcqen sdvfqqeqgi
     2161 sdllgksgit edarvlktec dswsrisnps afsivprraa kssrgnghfq ghlllpgeqi
     2221 qpkqekkggr ssadftvldl eeddeddnek tddsideivd vvsdyqseev ddveknncve
     2281 yieddeehvd ietveelsee invahlktta ahtqsfkqps cthisadeka aersrkappi
     2341 plklkpdyws dklqkeaeaf ayyrrthtan errrrgemrd lfeklkitlg llhsskvsks
     2401 liltrafsei qgltdqadkl igqknlltrk rnilirkvss lsgkteevvl kkleyiyakq
     2461 qaleaqkrkk kmgsdefdis priskqqegs sassvdlgqm finnrrgkpl ilsrkkdqat
     2521 entsplntph tsanlvmtpq gqlltlkgpl fsgpvvavsp dllesdlkpq vagsavalpe
     2581 nddlfmmpri vnvtslateg glvdmggsky phevpdskps dhlkdtvrne dnsledkgri
     2641 ssrgnrdgrv tlgptqvfla nkdsgypqiv dvsnmqkaqe flpkkisgdm rgiqykwkes
     2701 esrgervksk dssfhklkmk dlkdssieme lrkvtsaiee aaldssellt nmededdtde
     2761 tltsllneia flnqqlndds vglaelpssm dtefpgdarr afiskvppgs ratfqvehlg
     2821 tglkelpdvq gesdsispll lhledddfse nekqlaepas epdvlkivid seikdsllsn
     2881 kkaidggknt sglpaepesv sspptlhmkt glensnstdt lwrpmpklap lglkvanpss
     2941 dadgqslkvm pclapiaakv gsvghkmnlt gndqegresk vmptlapvva klgnsgasps
     3001 sagk
//
LOCUS       XP_047288237            3004 aa            linear   PRI 05-AUG-2025
DEFINITION  MAX gene-associated protein isoform X6 [Homo sapiens].
ACCESSION   XP_047288237
VERSION     XP_047288237.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432281.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..3004
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..3004
                     /product="MAX gene-associated protein isoform X6"
                     /calculated_mol_wt=329515
     Region          75..260
                     /region_name="T-box_MGA-like"
                     /note="DNA-binding domain of MAX gene-associated protein
                     and related T-box proteins; cd20195"
                     /db_xref="CDD:410321"
     Site            order(102..103,136,180,183,196..197,237..240,245,248..249,
                     252..258)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410321"
     Region          1041..1082
                     /region_name="MGA_dom"
                     /note="MGA, conserved domain; pfam16059"
                     /db_xref="CDD:464998"
     Region          <1409..1710
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          1600..>1922
                     /region_name="Atrophin-1"
                     /note="Atrophin-1 family; pfam03154"
                     /db_xref="CDD:460830"
     Region          2364..2428
                     /region_name="bHLHzip_MGA"
                     /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain
                     found in MAX gene-associated protein (MGA) and similar
                     proteins; cd18911"
                     /db_xref="CDD:381481"
     Site            order(2364,2366..2368,2370..2372,2374..2375,2379,
                     2398..2399)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381481"
     Site            order(2378,2381..2382,2384..2385,2388..2390,2400,
                     2403..2404,2407,2409..2411,2413..2414,2416..2417,2420,
                     2423..2424,2427..2428)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381481"
     CDS             1..3004
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /coded_by="XM_047432281.1:143..9157"
                     /db_xref="GeneID:23269"
                     /db_xref="HGNC:HGNC:14010"
                     /db_xref="MIM:616061"
ORIGIN      
        1 meekqqiila nqdggtvaga aptffvilkq pgngktdqgi lvtnqdacal assvsspvks
       61 kgkiclpadc tvggitvtld nnsmwnefyh rstemiltkq grrmfpycry witgldsnlk
      121 yilvmdispv dnhrykwngr wwepsgkaep hvlgrvfihp espstghywm hqpvsfyklk
      181 ltnntldqeg hiilhsmhry lprlhlvpae kaveviqlng pgvhtftfpq teffavtayq
      241 niqitqlkid ynpfakgfrd dglnnkpqrd gkqknssdqe gnnissssgh rvrltegqgs
      301 eiqpgdldpl srghetsgkg lektslnikr dflgfmdtds alsevpqlkq eisecliass
      361 feddsrvasp ldqngsfnvv ikeeplddyd yelgecpegv tvkqeetdee tdvysnsddd
      421 pilekqlkrh nkvdnpeadh lsskwlpssp sgvakakmfk ldtgkmpvvy lepcavtrst
      481 vkiselpdnm lstsrkdkss mlaeleylpt yiensnetaf clgkesengl rkhspdlrvv
      541 qkypllkepq wkypdisdsi sterilddsk dsvgdslsgk edlgrkrttm lkiataakvv
      601 nanqnaspnv pgkrgrprkl klckagrppk ntgkslistk ntpvspgstf pdvkpdledv
      661 dgvlfvsfes kealdihavd gtteessslq asttndsgyr arisqlekel iedlktlrhk
      721 qvihpglqev glklnsvdpt msidlkylgv qlplapatsf pfwnltgtnp aspdagfpfv
      781 srtgktndft kikgwrgkfh sasasrnegg nsesslknrs afcsdkldey lenegklmet
      841 smgfssnapt spvvyqlptk stsyvrtlds vlkkqstisp stsyslkphs vppvsrkaks
      901 qnrqatfsgr tkssyksilp ypvspkqkys hvilgdkvtk nssgiisenq annfvvptld
      961 enifpkqisl rqaqqqqqqq qgsrppglsk sqvklmdled calwegkprt yiteeradvs
     1021 lttlltaqas lktkpihtii rkrappcnnd fcrlgcvcss lalekrqpah crrpdcmfgc
     1081 tclkrkvvlv kggsktkhfq rkaahrdpvf ydtlgeeare eeegireeee qlkekkkrkk
     1141 leyticetep eqpvrhyplw vkvegevdpe pvyiptpsvi epmkplllpq pevlsptvkg
     1201 klltgikspr sytpkpnpvi reedkdpvyl yfesmmtcar vrvyerkked qrqpsssssp
     1261 spsfqqqtsc hsspenhnna kepdseqqpl kqltcdledd sdklqekswk sscnegesss
     1321 tsymhqrspg gptklieiis dcnweedrnk ilsilsqhin snmpqslkvn gksypqakll
     1381 lgqmgalhpa nrlaayitgr lrpsvldlst lstviskvas nakvaasrkp rtllpstsns
     1441 kmasssgtat nrpgknlkaf vpakrpiaar pspggvftqf vmskvgalqq kipgvstpqt
     1501 lagtqkfsir pspvmvvtpv vssepvqvcs pvtaavtttt pqvflentta vtpmtaisdv
     1561 etkettyssg atttgvvevs etntstsvts tqstatvnlt kttgittpva svafpkslva
     1621 spstitlpva stastslvvv taaasssmvt tptsslgsvp iilsgingsp pvsqrpenaa
     1681 qipvatpqvs pntvkragpr lllipvqqgs ptlrpvsntq lqghrmvlqp vrspsgmnlf
     1741 rhpngqivql lplhqlrgsn tqpnlqpvmf rnpgsvmgir lpapskpset ppsstsssaf
     1801 svmnpviqav gsssavnvit qapsllssga sfvsqagtlt lrisppepqs fasktgsetk
     1861 ityssggqpv gtasliplqs gsfallqlpg qkpvpssilq hvaslqmkre sqnpdqkdet
     1921 nsikreqetk kvlqsegeav dpeanvikqn sgaatseetl ndsledrgdh ldeeclpeeg
     1981 catvkpsehs citgshtdqd ykdvneeyga rnrksskekv avlevrtise kasnktvqnl
     2041 skvqhqklgd vkveqqkgfd npeenssefp vtfkeeskfe lsgskvmeqq snlqpeakek
     2101 ecgdslekdr erwrkhlkgp ltrkcvgasq eckkeadeql iketktcqen sdvfqqeqgi
     2161 sdllgksgit edarvlktec dswsrisnps afsivprraa kssrgnghfq ghlllpgeqi
     2221 qpkqekkggr ssadftvldl eeddeddnek tddsideivd vvsdyqseev ddveknncve
     2281 yieddeehvd ietveelsee invahlktta ahtqsfkqps cthisadeka aersrkappi
     2341 plklkpdyws dklqkeaeaf ayyrrthtan errrrgemrd lfeklkitlg llhsskvsks
     2401 liltrafsei qgltdqadkl igqknlltrk rnilirkvss lsgkteevvl kkleyiyakq
     2461 qaleaqkrkk kmgsdefdis priskqqegs sassvdlgqm finnrrgkpl ilsrkkdqat
     2521 entsplntph tsanlvmtpq gqlltlkgpl fsgpvvavsp dllesdlkpq vagsavalpe
     2581 nddlfmmpri vnvtslateg glvdmggsky phevpdskps dhlkdtvrne dnsledkgri
     2641 ssrgnrdgrv tlgptqvfla nkdsgypqiv dvsnmqkaqe flpkkisgdm rgiqykwkes
     2701 esrgervksk dssfhklkmk dlkdssieme lrkvtsaiee aaldssellt nmededdtde
     2761 tltsllneia flnqqlndds vglaelpssm dtefpgdarr afiskvppgs ratfqvehlg
     2821 tglkelpdvq gesdsispll lhledddfse nekqlaepas epdvlkivid seikdsllsn
     2881 kkaidggknt sglpaepesv sspptlhmkt glensnstdt lwrpmpklap lglkvanpss
     2941 dadgqslkvm pclapiaakv gsvghkmnlt gndqegresk vmptlapvva klgnsgasps
     3001 sagk
//
LOCUS       XP_047288238            3004 aa            linear   PRI 05-AUG-2025
DEFINITION  MAX gene-associated protein isoform X6 [Homo sapiens].
ACCESSION   XP_047288238
VERSION     XP_047288238.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432282.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..3004
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..3004
                     /product="MAX gene-associated protein isoform X6"
                     /calculated_mol_wt=329515
     Region          75..260
                     /region_name="T-box_MGA-like"
                     /note="DNA-binding domain of MAX gene-associated protein
                     and related T-box proteins; cd20195"
                     /db_xref="CDD:410321"
     Site            order(102..103,136,180,183,196..197,237..240,245,248..249,
                     252..258)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410321"
     Region          1041..1082
                     /region_name="MGA_dom"
                     /note="MGA, conserved domain; pfam16059"
                     /db_xref="CDD:464998"
     Region          <1409..1710
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          1600..>1922
                     /region_name="Atrophin-1"
                     /note="Atrophin-1 family; pfam03154"
                     /db_xref="CDD:460830"
     Region          2364..2428
                     /region_name="bHLHzip_MGA"
                     /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain
                     found in MAX gene-associated protein (MGA) and similar
                     proteins; cd18911"
                     /db_xref="CDD:381481"
     Site            order(2364,2366..2368,2370..2372,2374..2375,2379,
                     2398..2399)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381481"
     Site            order(2378,2381..2382,2384..2385,2388..2390,2400,
                     2403..2404,2407,2409..2411,2413..2414,2416..2417,2420,
                     2423..2424,2427..2428)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381481"
     CDS             1..3004
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /coded_by="XM_047432282.1:165..9179"
                     /db_xref="GeneID:23269"
                     /db_xref="HGNC:HGNC:14010"
                     /db_xref="MIM:616061"
ORIGIN      
        1 meekqqiila nqdggtvaga aptffvilkq pgngktdqgi lvtnqdacal assvsspvks
       61 kgkiclpadc tvggitvtld nnsmwnefyh rstemiltkq grrmfpycry witgldsnlk
      121 yilvmdispv dnhrykwngr wwepsgkaep hvlgrvfihp espstghywm hqpvsfyklk
      181 ltnntldqeg hiilhsmhry lprlhlvpae kaveviqlng pgvhtftfpq teffavtayq
      241 niqitqlkid ynpfakgfrd dglnnkpqrd gkqknssdqe gnnissssgh rvrltegqgs
      301 eiqpgdldpl srghetsgkg lektslnikr dflgfmdtds alsevpqlkq eisecliass
      361 feddsrvasp ldqngsfnvv ikeeplddyd yelgecpegv tvkqeetdee tdvysnsddd
      421 pilekqlkrh nkvdnpeadh lsskwlpssp sgvakakmfk ldtgkmpvvy lepcavtrst
      481 vkiselpdnm lstsrkdkss mlaeleylpt yiensnetaf clgkesengl rkhspdlrvv
      541 qkypllkepq wkypdisdsi sterilddsk dsvgdslsgk edlgrkrttm lkiataakvv
      601 nanqnaspnv pgkrgrprkl klckagrppk ntgkslistk ntpvspgstf pdvkpdledv
      661 dgvlfvsfes kealdihavd gtteessslq asttndsgyr arisqlekel iedlktlrhk
      721 qvihpglqev glklnsvdpt msidlkylgv qlplapatsf pfwnltgtnp aspdagfpfv
      781 srtgktndft kikgwrgkfh sasasrnegg nsesslknrs afcsdkldey lenegklmet
      841 smgfssnapt spvvyqlptk stsyvrtlds vlkkqstisp stsyslkphs vppvsrkaks
      901 qnrqatfsgr tkssyksilp ypvspkqkys hvilgdkvtk nssgiisenq annfvvptld
      961 enifpkqisl rqaqqqqqqq qgsrppglsk sqvklmdled calwegkprt yiteeradvs
     1021 lttlltaqas lktkpihtii rkrappcnnd fcrlgcvcss lalekrqpah crrpdcmfgc
     1081 tclkrkvvlv kggsktkhfq rkaahrdpvf ydtlgeeare eeegireeee qlkekkkrkk
     1141 leyticetep eqpvrhyplw vkvegevdpe pvyiptpsvi epmkplllpq pevlsptvkg
     1201 klltgikspr sytpkpnpvi reedkdpvyl yfesmmtcar vrvyerkked qrqpsssssp
     1261 spsfqqqtsc hsspenhnna kepdseqqpl kqltcdledd sdklqekswk sscnegesss
     1321 tsymhqrspg gptklieiis dcnweedrnk ilsilsqhin snmpqslkvn gksypqakll
     1381 lgqmgalhpa nrlaayitgr lrpsvldlst lstviskvas nakvaasrkp rtllpstsns
     1441 kmasssgtat nrpgknlkaf vpakrpiaar pspggvftqf vmskvgalqq kipgvstpqt
     1501 lagtqkfsir pspvmvvtpv vssepvqvcs pvtaavtttt pqvflentta vtpmtaisdv
     1561 etkettyssg atttgvvevs etntstsvts tqstatvnlt kttgittpva svafpkslva
     1621 spstitlpva stastslvvv taaasssmvt tptsslgsvp iilsgingsp pvsqrpenaa
     1681 qipvatpqvs pntvkragpr lllipvqqgs ptlrpvsntq lqghrmvlqp vrspsgmnlf
     1741 rhpngqivql lplhqlrgsn tqpnlqpvmf rnpgsvmgir lpapskpset ppsstsssaf
     1801 svmnpviqav gsssavnvit qapsllssga sfvsqagtlt lrisppepqs fasktgsetk
     1861 ityssggqpv gtasliplqs gsfallqlpg qkpvpssilq hvaslqmkre sqnpdqkdet
     1921 nsikreqetk kvlqsegeav dpeanvikqn sgaatseetl ndsledrgdh ldeeclpeeg
     1981 catvkpsehs citgshtdqd ykdvneeyga rnrksskekv avlevrtise kasnktvqnl
     2041 skvqhqklgd vkveqqkgfd npeenssefp vtfkeeskfe lsgskvmeqq snlqpeakek
     2101 ecgdslekdr erwrkhlkgp ltrkcvgasq eckkeadeql iketktcqen sdvfqqeqgi
     2161 sdllgksgit edarvlktec dswsrisnps afsivprraa kssrgnghfq ghlllpgeqi
     2221 qpkqekkggr ssadftvldl eeddeddnek tddsideivd vvsdyqseev ddveknncve
     2281 yieddeehvd ietveelsee invahlktta ahtqsfkqps cthisadeka aersrkappi
     2341 plklkpdyws dklqkeaeaf ayyrrthtan errrrgemrd lfeklkitlg llhsskvsks
     2401 liltrafsei qgltdqadkl igqknlltrk rnilirkvss lsgkteevvl kkleyiyakq
     2461 qaleaqkrkk kmgsdefdis priskqqegs sassvdlgqm finnrrgkpl ilsrkkdqat
     2521 entsplntph tsanlvmtpq gqlltlkgpl fsgpvvavsp dllesdlkpq vagsavalpe
     2581 nddlfmmpri vnvtslateg glvdmggsky phevpdskps dhlkdtvrne dnsledkgri
     2641 ssrgnrdgrv tlgptqvfla nkdsgypqiv dvsnmqkaqe flpkkisgdm rgiqykwkes
     2701 esrgervksk dssfhklkmk dlkdssieme lrkvtsaiee aaldssellt nmededdtde
     2761 tltsllneia flnqqlndds vglaelpssm dtefpgdarr afiskvppgs ratfqvehlg
     2821 tglkelpdvq gesdsispll lhledddfse nekqlaepas epdvlkivid seikdsllsn
     2881 kkaidggknt sglpaepesv sspptlhmkt glensnstdt lwrpmpklap lglkvanpss
     2941 dadgqslkvm pclapiaakv gsvghkmnlt gndqegresk vmptlapvva klgnsgasps
     3001 sagk
//
LOCUS       XP_005254309            2956 aa            linear   PRI 05-AUG-2025
DEFINITION  MAX gene-associated protein isoform X7 [Homo sapiens].
ACCESSION   XP_005254309
VERSION     XP_005254309.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254252.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2956
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2956
                     /product="MAX gene-associated protein isoform X7"
                     /calculated_mol_wt=324411
     Region          75..260
                     /region_name="T-box_MGA-like"
                     /note="DNA-binding domain of MAX gene-associated protein
                     and related T-box proteins; cd20195"
                     /db_xref="CDD:410321"
     Site            order(102..103,136,180,183,196..197,237..240,245,248..249,
                     252..258)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410321"
     Region          1041..1082
                     /region_name="MGA_dom"
                     /note="MGA, conserved domain; pfam16059"
                     /db_xref="CDD:464998"
     Region          1377..>1695
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          1551..>1873
                     /region_name="Atrophin-1"
                     /note="Atrophin-1 family; pfam03154"
                     /db_xref="CDD:460830"
     Region          2316..2380
                     /region_name="bHLHzip_MGA"
                     /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain
                     found in MAX gene-associated protein (MGA) and similar
                     proteins; cd18911"
                     /db_xref="CDD:381481"
     Site            order(2316,2318..2320,2322..2324,2326..2327,2331,
                     2350..2351)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381481"
     Site            order(2330,2333..2334,2336..2337,2340..2342,2352,
                     2355..2356,2359,2361..2363,2365..2366,2368..2369,2372,
                     2375..2376,2379..2380)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381481"
     CDS             1..2956
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /coded_by="XM_005254252.4:189..9059"
                     /db_xref="GeneID:23269"
                     /db_xref="HGNC:HGNC:14010"
                     /db_xref="MIM:616061"
ORIGIN      
        1 meekqqiila nqdggtvaga aptffvilkq pgngktdqgi lvtnqdacal assvsspvks
       61 kgkiclpadc tvggitvtld nnsmwnefyh rstemiltkq grrmfpycry witgldsnlk
      121 yilvmdispv dnhrykwngr wwepsgkaep hvlgrvfihp espstghywm hqpvsfyklk
      181 ltnntldqeg hiilhsmhry lprlhlvpae kaveviqlng pgvhtftfpq teffavtayq
      241 niqitqlkid ynpfakgfrd dglnnkpqrd gkqknssdqe gnnissssgh rvrltegqgs
      301 eiqpgdldpl srghetsgkg lektslnikr dflgfmdtds alsevpqlkq eisecliass
      361 feddsrvasp ldqngsfnvv ikeeplddyd yelgecpegv tvkqeetdee tdvysnsddd
      421 pilekqlkrh nkvdnpeadh lsskwlpssp sgvakakmfk ldtgkmpvvy lepcavtrst
      481 vkiselpdnm lstsrkdkss mlaeleylpt yiensnetaf clgkesengl rkhspdlrvv
      541 qkypllkepq wkypdisdsi sterilddsk dsvgdslsgk edlgrkrttm lkiataakvv
      601 nanqnaspnv pgkrgrprkl klckagrppk ntgkslistk ntpvspgstf pdvkpdledv
      661 dgvlfvsfes kealdihavd gtteessslq asttndsgyr arisqlekel iedlktlrhk
      721 qvihpglqev glklnsvdpt msidlkylgv qlplapatsf pfwnltgtnp aspdagfpfv
      781 srtgktndft kikgwrgkfh sasasrnegg nsesslknrs afcsdkldey lenegklmet
      841 smgfssnapt spvvyqlptk stsyvrtlds vlkkqstisp stsyslkphs vppvsrkaks
      901 qnrqatfsgr tkssyksilp ypvspkqkys hvilgdkvtk nssgiisenq annfvvptld
      961 enifpkqisl rqaqqqqqqq qgsrppglsk sqvklmdled calwegkprt yiteeradvs
     1021 lttlltaqas lktkpihtii rkrappcnnd fcrlgcvcss lalekrqpah crrpdcmfgc
     1081 tclkrkvvlv kggsktkhfq rkaahrdpvf ydtlgeeare eeegireeee qlkekkkrkk
     1141 leyticetep eqpvrhyplw vkvegevdpe pvyiptpsvi epmkplllpq pevlsptvkg
     1201 klltgikspr sytpkpnpvi reedkdpvyl yfesmmtcar vrvyerkked qrqpsssssp
     1261 spsfqqqtsc hsspenhnna kepdseqqpl kqltcdledd sdklqekswk sscnegesss
     1321 tsymhqrspg gptklieiis dcnweedrnk ilsilsqhin snmpqslkva snakvaasrk
     1381 prtllpstsn skmasssgta tnrpgknlka fvpakrpiaa rpspggvftq fvmskvgalq
     1441 qkipgvstpq tlagtqkfsi rpspvmvvtp vvssepvqvc spvtaavttt tpqvflentt
     1501 avtpmtaisd vetkettyss gatttgvvev setntstsvt stqstatvnl tkttgittpv
     1561 asvafpkslv aspstitlpv astastslvv vtaaasssmv ttptsslgsv piilsgings
     1621 ppvsqrpena aqipvatpqv spntvkragp rlllipvqqg sptlrpvsnt qlqghrmvlq
     1681 pvrspsgmnl frhpngqivq llplhqlrgs ntqpnlqpvm frnpgsvmgi rlpapskpse
     1741 tppsstsssa fsvmnpviqa vgsssavnvi tqapsllssg asfvsqagtl tlrisppepq
     1801 sfasktgset kityssggqp vgtasliplq sgsfallqlp gqkpvpssil qhvaslqmkr
     1861 esqnpdqkde tnsikreqet kkvlqsegea vdpeanvikq nsgaatseet lndsledrgd
     1921 hldeeclpee gcatvkpseh scitgshtdq dykdvneeyg arnrksskek vavlevrtis
     1981 ekasnktvqn lskvqhqklg dvkveqqkgf dnpeenssef pvtfkeeskf elsgskvmeq
     2041 qsnlqpeake kecgdslekd rerwrkhlkg pltrkcvgas qeckkeadeq liketktcqe
     2101 nsdvfqqeqg isdllgksgi tedarvlkte cdswsrisnp safsivprra akssrgnghf
     2161 qghlllpgeq iqpkqekkgg rssadftvld leeddeddne ktddsideiv dvvsdyqsee
     2221 vddvekvnnc veyieddeeh vdietveels eeinvahlkt taahtqsfkq pscthisade
     2281 kaaersrkap piplklkpdy wsdklqkeae afayyrrtht anerrrrgem rdlfeklkit
     2341 lgllhsskvs ksliltrafs eiqgltdqad kligqknllt rkrnilirkv sslsgkteev
     2401 vlkkleyiya kqqaleaqkr kkkmgsdefd ispriskqqe gssassvdlg qmfinnrrgk
     2461 plilsrkkdq atentsplnt phtsanlvmt pqgqlltlkg plfsgpvvav spdllesdlk
     2521 pqvagsaval penddlfmmp rivnvtslat egglvdmggs kyphevpdsk psdhlkdtvr
     2581 nednsledkg rissrgnrdg rvtlgptqvf lankdsgypq ivdvsnmqka qeflpkkisg
     2641 dmrgiqykwk esesrgervk skdssfhklk mkdlkdssie melrkvtsai eeaaldssel
     2701 ltnmededdt detltsllne iaflnqqlnd dsvglaelps smdtefpgda rrafiskvpp
     2761 gsratfqveh lgtglkelpd vqgesdsisp lllhledddf senekqlaep asepdvlkiv
     2821 idseikdsll snkkaidggk ntsglpaepe svsspptlhm ktglensnst dtlwrpmpkl
     2881 aplglkvanp ssdadgqslk vmpclapiaa kvgsvghkmn ltgndqegre skvmptlapv
     2941 vaklgnsgas pssagk
//
LOCUS       XP_047288239            2955 aa            linear   PRI 05-AUG-2025
DEFINITION  MAX gene-associated protein isoform X8 [Homo sapiens].
ACCESSION   XP_047288239
VERSION     XP_047288239.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432283.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2955
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2955
                     /product="MAX gene-associated protein isoform X8"
                     /calculated_mol_wt=324312
     Region          75..260
                     /region_name="T-box_MGA-like"
                     /note="DNA-binding domain of MAX gene-associated protein
                     and related T-box proteins; cd20195"
                     /db_xref="CDD:410321"
     Site            order(102..103,136,180,183,196..197,237..240,245,248..249,
                     252..258)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410321"
     Region          1041..1082
                     /region_name="MGA_dom"
                     /note="MGA, conserved domain; pfam16059"
                     /db_xref="CDD:464998"
     Region          1377..>1695
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          1551..>1873
                     /region_name="Atrophin-1"
                     /note="Atrophin-1 family; pfam03154"
                     /db_xref="CDD:460830"
     Region          2315..2379
                     /region_name="bHLHzip_MGA"
                     /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain
                     found in MAX gene-associated protein (MGA) and similar
                     proteins; cd18911"
                     /db_xref="CDD:381481"
     Site            order(2315,2317..2319,2321..2323,2325..2326,2330,
                     2349..2350)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381481"
     Site            order(2329,2332..2333,2335..2336,2339..2341,2351,
                     2354..2355,2358,2360..2362,2364..2365,2367..2368,2371,
                     2374..2375,2378..2379)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381481"
     CDS             1..2955
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /coded_by="XM_047432283.1:189..9056"
                     /db_xref="GeneID:23269"
                     /db_xref="HGNC:HGNC:14010"
                     /db_xref="MIM:616061"
ORIGIN      
        1 meekqqiila nqdggtvaga aptffvilkq pgngktdqgi lvtnqdacal assvsspvks
       61 kgkiclpadc tvggitvtld nnsmwnefyh rstemiltkq grrmfpycry witgldsnlk
      121 yilvmdispv dnhrykwngr wwepsgkaep hvlgrvfihp espstghywm hqpvsfyklk
      181 ltnntldqeg hiilhsmhry lprlhlvpae kaveviqlng pgvhtftfpq teffavtayq
      241 niqitqlkid ynpfakgfrd dglnnkpqrd gkqknssdqe gnnissssgh rvrltegqgs
      301 eiqpgdldpl srghetsgkg lektslnikr dflgfmdtds alsevpqlkq eisecliass
      361 feddsrvasp ldqngsfnvv ikeeplddyd yelgecpegv tvkqeetdee tdvysnsddd
      421 pilekqlkrh nkvdnpeadh lsskwlpssp sgvakakmfk ldtgkmpvvy lepcavtrst
      481 vkiselpdnm lstsrkdkss mlaeleylpt yiensnetaf clgkesengl rkhspdlrvv
      541 qkypllkepq wkypdisdsi sterilddsk dsvgdslsgk edlgrkrttm lkiataakvv
      601 nanqnaspnv pgkrgrprkl klckagrppk ntgkslistk ntpvspgstf pdvkpdledv
      661 dgvlfvsfes kealdihavd gtteessslq asttndsgyr arisqlekel iedlktlrhk
      721 qvihpglqev glklnsvdpt msidlkylgv qlplapatsf pfwnltgtnp aspdagfpfv
      781 srtgktndft kikgwrgkfh sasasrnegg nsesslknrs afcsdkldey lenegklmet
      841 smgfssnapt spvvyqlptk stsyvrtlds vlkkqstisp stsyslkphs vppvsrkaks
      901 qnrqatfsgr tkssyksilp ypvspkqkys hvilgdkvtk nssgiisenq annfvvptld
      961 enifpkqisl rqaqqqqqqq qgsrppglsk sqvklmdled calwegkprt yiteeradvs
     1021 lttlltaqas lktkpihtii rkrappcnnd fcrlgcvcss lalekrqpah crrpdcmfgc
     1081 tclkrkvvlv kggsktkhfq rkaahrdpvf ydtlgeeare eeegireeee qlkekkkrkk
     1141 leyticetep eqpvrhyplw vkvegevdpe pvyiptpsvi epmkplllpq pevlsptvkg
     1201 klltgikspr sytpkpnpvi reedkdpvyl yfesmmtcar vrvyerkked qrqpsssssp
     1261 spsfqqqtsc hsspenhnna kepdseqqpl kqltcdledd sdklqekswk sscnegesss
     1321 tsymhqrspg gptklieiis dcnweedrnk ilsilsqhin snmpqslkva snakvaasrk
     1381 prtllpstsn skmasssgta tnrpgknlka fvpakrpiaa rpspggvftq fvmskvgalq
     1441 qkipgvstpq tlagtqkfsi rpspvmvvtp vvssepvqvc spvtaavttt tpqvflentt
     1501 avtpmtaisd vetkettyss gatttgvvev setntstsvt stqstatvnl tkttgittpv
     1561 asvafpkslv aspstitlpv astastslvv vtaaasssmv ttptsslgsv piilsgings
     1621 ppvsqrpena aqipvatpqv spntvkragp rlllipvqqg sptlrpvsnt qlqghrmvlq
     1681 pvrspsgmnl frhpngqivq llplhqlrgs ntqpnlqpvm frnpgsvmgi rlpapskpse
     1741 tppsstsssa fsvmnpviqa vgsssavnvi tqapsllssg asfvsqagtl tlrisppepq
     1801 sfasktgset kityssggqp vgtasliplq sgsfallqlp gqkpvpssil qhvaslqmkr
     1861 esqnpdqkde tnsikreqet kkvlqsegea vdpeanvikq nsgaatseet lndsledrgd
     1921 hldeeclpee gcatvkpseh scitgshtdq dykdvneeyg arnrksskek vavlevrtis
     1981 ekasnktvqn lskvqhqklg dvkveqqkgf dnpeenssef pvtfkeeskf elsgskvmeq
     2041 qsnlqpeake kecgdslekd rerwrkhlkg pltrkcvgas qeckkeadeq liketktcqe
     2101 nsdvfqqeqg isdllgksgi tedarvlkte cdswsrisnp safsivprra akssrgnghf
     2161 qghlllpgeq iqpkqekkgg rssadftvld leeddeddne ktddsideiv dvvsdyqsee
     2221 vddveknncv eyieddeehv dietveelse einvahlktt aahtqsfkqp scthisadek
     2281 aaersrkapp iplklkpdyw sdklqkeaea fayyrrthta nerrrrgemr dlfeklkitl
     2341 gllhsskvsk sliltrafse iqgltdqadk ligqknlltr krnilirkvs slsgkteevv
     2401 lkkleyiyak qqaleaqkrk kkmgsdefdi spriskqqeg ssassvdlgq mfinnrrgkp
     2461 lilsrkkdqa tentsplntp htsanlvmtp qgqlltlkgp lfsgpvvavs pdllesdlkp
     2521 qvagsavalp enddlfmmpr ivnvtslate gglvdmggsk yphevpdskp sdhlkdtvrn
     2581 ednsledkgr issrgnrdgr vtlgptqvfl ankdsgypqi vdvsnmqkaq eflpkkisgd
     2641 mrgiqykwke sesrgervks kdssfhklkm kdlkdssiem elrkvtsaie eaaldssell
     2701 tnmededdtd etltsllnei aflnqqlndd svglaelpss mdtefpgdar rafiskvppg
     2761 sratfqvehl gtglkelpdv qgesdsispl llhledddfs enekqlaepa sepdvlkivi
     2821 dseikdslls nkkaidggkn tsglpaepes vsspptlhmk tglensnstd tlwrpmpkla
     2881 plglkvanps sdadgqslkv mpclapiaak vgsvghkmnl tgndqegres kvmptlapvv
     2941 aklgnsgasp ssagk
//
LOCUS       XP_047288241            2955 aa            linear   PRI 05-AUG-2025
DEFINITION  MAX gene-associated protein isoform X8 [Homo sapiens].
ACCESSION   XP_047288241
VERSION     XP_047288241.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432285.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2955
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2955
                     /product="MAX gene-associated protein isoform X8"
                     /calculated_mol_wt=324312
     Region          75..260
                     /region_name="T-box_MGA-like"
                     /note="DNA-binding domain of MAX gene-associated protein
                     and related T-box proteins; cd20195"
                     /db_xref="CDD:410321"
     Site            order(102..103,136,180,183,196..197,237..240,245,248..249,
                     252..258)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410321"
     Region          1041..1082
                     /region_name="MGA_dom"
                     /note="MGA, conserved domain; pfam16059"
                     /db_xref="CDD:464998"
     Region          1377..>1695
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          1551..>1873
                     /region_name="Atrophin-1"
                     /note="Atrophin-1 family; pfam03154"
                     /db_xref="CDD:460830"
     Region          2315..2379
                     /region_name="bHLHzip_MGA"
                     /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain
                     found in MAX gene-associated protein (MGA) and similar
                     proteins; cd18911"
                     /db_xref="CDD:381481"
     Site            order(2315,2317..2319,2321..2323,2325..2326,2330,
                     2349..2350)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381481"
     Site            order(2329,2332..2333,2335..2336,2339..2341,2351,
                     2354..2355,2358,2360..2362,2364..2365,2367..2368,2371,
                     2374..2375,2378..2379)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381481"
     CDS             1..2955
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /coded_by="XM_047432285.1:165..9032"
                     /db_xref="GeneID:23269"
                     /db_xref="HGNC:HGNC:14010"
                     /db_xref="MIM:616061"
ORIGIN      
        1 meekqqiila nqdggtvaga aptffvilkq pgngktdqgi lvtnqdacal assvsspvks
       61 kgkiclpadc tvggitvtld nnsmwnefyh rstemiltkq grrmfpycry witgldsnlk
      121 yilvmdispv dnhrykwngr wwepsgkaep hvlgrvfihp espstghywm hqpvsfyklk
      181 ltnntldqeg hiilhsmhry lprlhlvpae kaveviqlng pgvhtftfpq teffavtayq
      241 niqitqlkid ynpfakgfrd dglnnkpqrd gkqknssdqe gnnissssgh rvrltegqgs
      301 eiqpgdldpl srghetsgkg lektslnikr dflgfmdtds alsevpqlkq eisecliass
      361 feddsrvasp ldqngsfnvv ikeeplddyd yelgecpegv tvkqeetdee tdvysnsddd
      421 pilekqlkrh nkvdnpeadh lsskwlpssp sgvakakmfk ldtgkmpvvy lepcavtrst
      481 vkiselpdnm lstsrkdkss mlaeleylpt yiensnetaf clgkesengl rkhspdlrvv
      541 qkypllkepq wkypdisdsi sterilddsk dsvgdslsgk edlgrkrttm lkiataakvv
      601 nanqnaspnv pgkrgrprkl klckagrppk ntgkslistk ntpvspgstf pdvkpdledv
      661 dgvlfvsfes kealdihavd gtteessslq asttndsgyr arisqlekel iedlktlrhk
      721 qvihpglqev glklnsvdpt msidlkylgv qlplapatsf pfwnltgtnp aspdagfpfv
      781 srtgktndft kikgwrgkfh sasasrnegg nsesslknrs afcsdkldey lenegklmet
      841 smgfssnapt spvvyqlptk stsyvrtlds vlkkqstisp stsyslkphs vppvsrkaks
      901 qnrqatfsgr tkssyksilp ypvspkqkys hvilgdkvtk nssgiisenq annfvvptld
      961 enifpkqisl rqaqqqqqqq qgsrppglsk sqvklmdled calwegkprt yiteeradvs
     1021 lttlltaqas lktkpihtii rkrappcnnd fcrlgcvcss lalekrqpah crrpdcmfgc
     1081 tclkrkvvlv kggsktkhfq rkaahrdpvf ydtlgeeare eeegireeee qlkekkkrkk
     1141 leyticetep eqpvrhyplw vkvegevdpe pvyiptpsvi epmkplllpq pevlsptvkg
     1201 klltgikspr sytpkpnpvi reedkdpvyl yfesmmtcar vrvyerkked qrqpsssssp
     1261 spsfqqqtsc hsspenhnna kepdseqqpl kqltcdledd sdklqekswk sscnegesss
     1321 tsymhqrspg gptklieiis dcnweedrnk ilsilsqhin snmpqslkva snakvaasrk
     1381 prtllpstsn skmasssgta tnrpgknlka fvpakrpiaa rpspggvftq fvmskvgalq
     1441 qkipgvstpq tlagtqkfsi rpspvmvvtp vvssepvqvc spvtaavttt tpqvflentt
     1501 avtpmtaisd vetkettyss gatttgvvev setntstsvt stqstatvnl tkttgittpv
     1561 asvafpkslv aspstitlpv astastslvv vtaaasssmv ttptsslgsv piilsgings
     1621 ppvsqrpena aqipvatpqv spntvkragp rlllipvqqg sptlrpvsnt qlqghrmvlq
     1681 pvrspsgmnl frhpngqivq llplhqlrgs ntqpnlqpvm frnpgsvmgi rlpapskpse
     1741 tppsstsssa fsvmnpviqa vgsssavnvi tqapsllssg asfvsqagtl tlrisppepq
     1801 sfasktgset kityssggqp vgtasliplq sgsfallqlp gqkpvpssil qhvaslqmkr
     1861 esqnpdqkde tnsikreqet kkvlqsegea vdpeanvikq nsgaatseet lndsledrgd
     1921 hldeeclpee gcatvkpseh scitgshtdq dykdvneeyg arnrksskek vavlevrtis
     1981 ekasnktvqn lskvqhqklg dvkveqqkgf dnpeenssef pvtfkeeskf elsgskvmeq
     2041 qsnlqpeake kecgdslekd rerwrkhlkg pltrkcvgas qeckkeadeq liketktcqe
     2101 nsdvfqqeqg isdllgksgi tedarvlkte cdswsrisnp safsivprra akssrgnghf
     2161 qghlllpgeq iqpkqekkgg rssadftvld leeddeddne ktddsideiv dvvsdyqsee
     2221 vddveknncv eyieddeehv dietveelse einvahlktt aahtqsfkqp scthisadek
     2281 aaersrkapp iplklkpdyw sdklqkeaea fayyrrthta nerrrrgemr dlfeklkitl
     2341 gllhsskvsk sliltrafse iqgltdqadk ligqknlltr krnilirkvs slsgkteevv
     2401 lkkleyiyak qqaleaqkrk kkmgsdefdi spriskqqeg ssassvdlgq mfinnrrgkp
     2461 lilsrkkdqa tentsplntp htsanlvmtp qgqlltlkgp lfsgpvvavs pdllesdlkp
     2521 qvagsavalp enddlfmmpr ivnvtslate gglvdmggsk yphevpdskp sdhlkdtvrn
     2581 ednsledkgr issrgnrdgr vtlgptqvfl ankdsgypqi vdvsnmqkaq eflpkkisgd
     2641 mrgiqykwke sesrgervks kdssfhklkm kdlkdssiem elrkvtsaie eaaldssell
     2701 tnmededdtd etltsllnei aflnqqlndd svglaelpss mdtefpgdar rafiskvppg
     2761 sratfqvehl gtglkelpdv qgesdsispl llhledddfs enekqlaepa sepdvlkivi
     2821 dseikdslls nkkaidggkn tsglpaepes vsspptlhmk tglensnstd tlwrpmpkla
     2881 plglkvanps sdadgqslkv mpclapiaak vgsvghkmnl tgndqegres kvmptlapvv
     2941 aklgnsgasp ssagk
//
LOCUS       XP_005254310            2906 aa            linear   PRI 05-AUG-2025
DEFINITION  MAX gene-associated protein isoform X9 [Homo sapiens].
ACCESSION   XP_005254310
VERSION     XP_005254310.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254253.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2906
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2906
                     /product="MAX gene-associated protein isoform X9"
                     /calculated_mol_wt=320391
     Region          75..260
                     /region_name="T-box_MGA-like"
                     /note="DNA-binding domain of MAX gene-associated protein
                     and related T-box proteins; cd20195"
                     /db_xref="CDD:410321"
     Site            order(102..103,136,180,183,196..197,237..240,245,248..249,
                     252..258)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410321"
     Region          1041..1082
                     /region_name="MGA_dom"
                     /note="MGA, conserved domain; pfam16059"
                     /db_xref="CDD:464998"
     Region          2266..2330
                     /region_name="bHLHzip_MGA"
                     /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain
                     found in MAX gene-associated protein (MGA) and similar
                     proteins; cd18911"
                     /db_xref="CDD:381481"
     Site            order(2266,2268..2270,2272..2274,2276..2277,2281,
                     2300..2301)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381481"
     Site            order(2280,2283..2284,2286..2287,2290..2292,2302,
                     2305..2306,2309,2311..2313,2315..2316,2318..2319,2322,
                     2325..2326,2329..2330)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381481"
     CDS             1..2906
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /coded_by="XM_005254253.4:189..8909"
                     /db_xref="GeneID:23269"
                     /db_xref="HGNC:HGNC:14010"
                     /db_xref="MIM:616061"
ORIGIN      
        1 meekqqiila nqdggtvaga aptffvilkq pgngktdqgi lvtnqdacal assvsspvks
       61 kgkiclpadc tvggitvtld nnsmwnefyh rstemiltkq grrmfpycry witgldsnlk
      121 yilvmdispv dnhrykwngr wwepsgkaep hvlgrvfihp espstghywm hqpvsfyklk
      181 ltnntldqeg hiilhsmhry lprlhlvpae kaveviqlng pgvhtftfpq teffavtayq
      241 niqitqlkid ynpfakgfrd dglnnkpqrd gkqknssdqe gnnissssgh rvrltegqgs
      301 eiqpgdldpl srghetsgkg lektslnikr dflgfmdtds alsevpqlkq eisecliass
      361 feddsrvasp ldqngsfnvv ikeeplddyd yelgecpegv tvkqeetdee tdvysnsddd
      421 pilekqlkrh nkvdnpeadh lsskwlpssp sgvakakmfk ldtgkmpvvy lepcavtrst
      481 vkiselpdnm lstsrkdkss mlaeleylpt yiensnetaf clgkesengl rkhspdlrvv
      541 qkypllkepq wkypdisdsi sterilddsk dsvgdslsgk edlgrkrttm lkiataakvv
      601 nanqnaspnv pgkrgrprkl klckagrppk ntgkslistk ntpvspgstf pdvkpdledv
      661 dgvlfvsfes kealdihavd gtteessslq asttndsgyr arisqlekel iedlktlrhk
      721 qvihpglqev glklnsvdpt msidlkylgv qlplapatsf pfwnltgtnp aspdagfpfv
      781 srtgktndft kikgwrgkfh sasasrnegg nsesslknrs afcsdkldey lenegklmet
      841 smgfssnapt spvvyqlptk stsyvrtlds vlkkqstisp stsyslkphs vppvsrkaks
      901 qnrqatfsgr tkssyksilp ypvspkqkys hvilgdkvtk nssgiisenq annfvvptld
      961 enifpkqisl rqaqqqqqqq qgsrppglsk sqvklmdled calwegkprt yiteeradvs
     1021 lttlltaqas lktkpihtii rkrappcnnd fcrlgcvcss lalekrqpah crrpdcmfgc
     1081 tclkrkvvlv kggsktkhfq rkaahrdpvf ydtlgeeare eeegireeee qlkekkkrkk
     1141 leyticetep eqpvrhyplw vkvegevdpe pvyiptpsvi epmkplllpq pevlsptvkg
     1201 klltgikspr sytpkpnpvi reedkdpvyl yfesmmtcar vrvyerkked qrqpsssssp
     1261 spsfqqqtsc hsspenhnna kepdseqqpl kqltcdledd sdklqekswk sscnegesss
     1321 tsymhqrspg gptklieiis dcnweedrnk ilsilsqhin snmpqslkvg sfiielasqr
     1381 ksrgeknppv yssrvkismp scqdqddmae ksgsetpdgp lspgkmedis pvqtdaldsv
     1441 rerlhggkgl pfyaglspag klvaykrkps sstsgliqvn gksypqakll lgqmgalhpa
     1501 nrlaayitgr lrpsvldlst lstviskvas nakvaasrkp rtllpstsns kmasssgtat
     1561 nrpgknlkaf vpakrpiena aqipvatpqv spntvkragp rlllipvqqg sptlrpvsnt
     1621 qlqghrmvlq pvrspsgmnl frhpngqivq llplhqlrgs ntqpnlqpvm frnpgsvmgi
     1681 rlpapskpse tppsstsssa fsvmnpviqa vgsssavnvi tqapsllssg asfvsqagtl
     1741 tlrisppepq sfasktgset kityssggqp vgtasliplq sgsfallqlp gqkpvpssil
     1801 qhvaslqmkr esqnpdqkde tnsikreqet kkvlqsegea vdpeanvikq nsgaatseet
     1861 lndsledrgd hldeeclpee gcatvkpseh scitgshtdq dykdvneeyg arnrksskek
     1921 vavlevrtis ekasnktvqn lskvqhqklg dvkveqqkgf dnpeenssef pvtfkeeskf
     1981 elsgskvmeq qsnlqpeake kecgdslekd rerwrkhlkg pltrkcvgas qeckkeadeq
     2041 liketktcqe nsdvfqqeqg isdllgksgi tedarvlkte cdswsrisnp safsivprra
     2101 akssrgnghf qghlllpgeq iqpkqekkgg rssadftvld leeddeddne ktddsideiv
     2161 dvvsdyqsee vddvekvnnc veyieddeeh vdietveels eeinvahlkt taahtqsfkq
     2221 pscthisade kaaersrkap piplklkpdy wsdklqkeae afayyrrtht anerrrrgem
     2281 rdlfeklkit lgllhsskvs ksliltrafs eiqgltdqad kligqknllt rkrnilirkv
     2341 sslsgkteev vlkkleyiya kqqaleaqkr kkkmgsdefd ispriskqqe gssassvdlg
     2401 qmfinnrrgk plilsrkkdq atentsplnt phtsanlvmt pqgqlltlkg plfsgpvvav
     2461 spdllesdlk pqvagsaval penddlfmmp rivnvtslat egglvdmggs kyphevpdsk
     2521 psdhlkdtvr nednsledkg rissrgnrdg rvtlgptqvf lankdsgypq ivdvsnmqka
     2581 qeflpkkisg dmrgiqykwk esesrgervk skdssfhklk mkdlkdssie melrkvtsai
     2641 eeaaldssel ltnmededdt detltsllne iaflnqqlnd dsvglaelps smdtefpgda
     2701 rrafiskvpp gsratfqveh lgtglkelpd vqgesdsisp lllhledddf senekqlaep
     2761 asepdvlkiv idseikdsll snkkaidggk ntsglpaepe svsspptlhm ktglensnst
     2821 dtlwrpmpkl aplglkvanp ssdadgqslk vmpclapiaa kvgsvghkmn ltgndqegre
     2881 skvmptlapv vaklgnsgas pssagk
//
LOCUS       XP_047288242            2906 aa            linear   PRI 05-AUG-2025
DEFINITION  MAX gene-associated protein isoform X9 [Homo sapiens].
ACCESSION   XP_047288242
VERSION     XP_047288242.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432286.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2906
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2906
                     /product="MAX gene-associated protein isoform X9"
                     /calculated_mol_wt=320391
     Region          75..260
                     /region_name="T-box_MGA-like"
                     /note="DNA-binding domain of MAX gene-associated protein
                     and related T-box proteins; cd20195"
                     /db_xref="CDD:410321"
     Site            order(102..103,136,180,183,196..197,237..240,245,248..249,
                     252..258)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410321"
     Region          1041..1082
                     /region_name="MGA_dom"
                     /note="MGA, conserved domain; pfam16059"
                     /db_xref="CDD:464998"
     Region          2266..2330
                     /region_name="bHLHzip_MGA"
                     /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain
                     found in MAX gene-associated protein (MGA) and similar
                     proteins; cd18911"
                     /db_xref="CDD:381481"
     Site            order(2266,2268..2270,2272..2274,2276..2277,2281,
                     2300..2301)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381481"
     Site            order(2280,2283..2284,2286..2287,2290..2292,2302,
                     2305..2306,2309,2311..2313,2315..2316,2318..2319,2322,
                     2325..2326,2329..2330)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381481"
     CDS             1..2906
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /coded_by="XM_047432286.1:143..8863"
                     /db_xref="GeneID:23269"
                     /db_xref="HGNC:HGNC:14010"
                     /db_xref="MIM:616061"
ORIGIN      
        1 meekqqiila nqdggtvaga aptffvilkq pgngktdqgi lvtnqdacal assvsspvks
       61 kgkiclpadc tvggitvtld nnsmwnefyh rstemiltkq grrmfpycry witgldsnlk
      121 yilvmdispv dnhrykwngr wwepsgkaep hvlgrvfihp espstghywm hqpvsfyklk
      181 ltnntldqeg hiilhsmhry lprlhlvpae kaveviqlng pgvhtftfpq teffavtayq
      241 niqitqlkid ynpfakgfrd dglnnkpqrd gkqknssdqe gnnissssgh rvrltegqgs
      301 eiqpgdldpl srghetsgkg lektslnikr dflgfmdtds alsevpqlkq eisecliass
      361 feddsrvasp ldqngsfnvv ikeeplddyd yelgecpegv tvkqeetdee tdvysnsddd
      421 pilekqlkrh nkvdnpeadh lsskwlpssp sgvakakmfk ldtgkmpvvy lepcavtrst
      481 vkiselpdnm lstsrkdkss mlaeleylpt yiensnetaf clgkesengl rkhspdlrvv
      541 qkypllkepq wkypdisdsi sterilddsk dsvgdslsgk edlgrkrttm lkiataakvv
      601 nanqnaspnv pgkrgrprkl klckagrppk ntgkslistk ntpvspgstf pdvkpdledv
      661 dgvlfvsfes kealdihavd gtteessslq asttndsgyr arisqlekel iedlktlrhk
      721 qvihpglqev glklnsvdpt msidlkylgv qlplapatsf pfwnltgtnp aspdagfpfv
      781 srtgktndft kikgwrgkfh sasasrnegg nsesslknrs afcsdkldey lenegklmet
      841 smgfssnapt spvvyqlptk stsyvrtlds vlkkqstisp stsyslkphs vppvsrkaks
      901 qnrqatfsgr tkssyksilp ypvspkqkys hvilgdkvtk nssgiisenq annfvvptld
      961 enifpkqisl rqaqqqqqqq qgsrppglsk sqvklmdled calwegkprt yiteeradvs
     1021 lttlltaqas lktkpihtii rkrappcnnd fcrlgcvcss lalekrqpah crrpdcmfgc
     1081 tclkrkvvlv kggsktkhfq rkaahrdpvf ydtlgeeare eeegireeee qlkekkkrkk
     1141 leyticetep eqpvrhyplw vkvegevdpe pvyiptpsvi epmkplllpq pevlsptvkg
     1201 klltgikspr sytpkpnpvi reedkdpvyl yfesmmtcar vrvyerkked qrqpsssssp
     1261 spsfqqqtsc hsspenhnna kepdseqqpl kqltcdledd sdklqekswk sscnegesss
     1321 tsymhqrspg gptklieiis dcnweedrnk ilsilsqhin snmpqslkvg sfiielasqr
     1381 ksrgeknppv yssrvkismp scqdqddmae ksgsetpdgp lspgkmedis pvqtdaldsv
     1441 rerlhggkgl pfyaglspag klvaykrkps sstsgliqvn gksypqakll lgqmgalhpa
     1501 nrlaayitgr lrpsvldlst lstviskvas nakvaasrkp rtllpstsns kmasssgtat
     1561 nrpgknlkaf vpakrpiena aqipvatpqv spntvkragp rlllipvqqg sptlrpvsnt
     1621 qlqghrmvlq pvrspsgmnl frhpngqivq llplhqlrgs ntqpnlqpvm frnpgsvmgi
     1681 rlpapskpse tppsstsssa fsvmnpviqa vgsssavnvi tqapsllssg asfvsqagtl
     1741 tlrisppepq sfasktgset kityssggqp vgtasliplq sgsfallqlp gqkpvpssil
     1801 qhvaslqmkr esqnpdqkde tnsikreqet kkvlqsegea vdpeanvikq nsgaatseet
     1861 lndsledrgd hldeeclpee gcatvkpseh scitgshtdq dykdvneeyg arnrksskek
     1921 vavlevrtis ekasnktvqn lskvqhqklg dvkveqqkgf dnpeenssef pvtfkeeskf
     1981 elsgskvmeq qsnlqpeake kecgdslekd rerwrkhlkg pltrkcvgas qeckkeadeq
     2041 liketktcqe nsdvfqqeqg isdllgksgi tedarvlkte cdswsrisnp safsivprra
     2101 akssrgnghf qghlllpgeq iqpkqekkgg rssadftvld leeddeddne ktddsideiv
     2161 dvvsdyqsee vddvekvnnc veyieddeeh vdietveels eeinvahlkt taahtqsfkq
     2221 pscthisade kaaersrkap piplklkpdy wsdklqkeae afayyrrtht anerrrrgem
     2281 rdlfeklkit lgllhsskvs ksliltrafs eiqgltdqad kligqknllt rkrnilirkv
     2341 sslsgkteev vlkkleyiya kqqaleaqkr kkkmgsdefd ispriskqqe gssassvdlg
     2401 qmfinnrrgk plilsrkkdq atentsplnt phtsanlvmt pqgqlltlkg plfsgpvvav
     2461 spdllesdlk pqvagsaval penddlfmmp rivnvtslat egglvdmggs kyphevpdsk
     2521 psdhlkdtvr nednsledkg rissrgnrdg rvtlgptqvf lankdsgypq ivdvsnmqka
     2581 qeflpkkisg dmrgiqykwk esesrgervk skdssfhklk mkdlkdssie melrkvtsai
     2641 eeaaldssel ltnmededdt detltsllne iaflnqqlnd dsvglaelps smdtefpgda
     2701 rrafiskvpp gsratfqveh lgtglkelpd vqgesdsisp lllhledddf senekqlaep
     2761 asepdvlkiv idseikdsll snkkaidggk ntsglpaepe svsspptlhm ktglensnst
     2821 dtlwrpmpkl aplglkvanp ssdadgqslk vmpclapiaa kvgsvghkmn ltgndqegre
     2881 skvmptlapv vaklgnsgas pssagk
//
LOCUS       XP_047288243            2905 aa            linear   PRI 05-AUG-2025
DEFINITION  MAX gene-associated protein isoform X10 [Homo sapiens].
ACCESSION   XP_047288243
VERSION     XP_047288243.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432287.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2905
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2905
                     /product="MAX gene-associated protein isoform X10"
                     /calculated_mol_wt=320292
     Region          75..260
                     /region_name="T-box_MGA-like"
                     /note="DNA-binding domain of MAX gene-associated protein
                     and related T-box proteins; cd20195"
                     /db_xref="CDD:410321"
     Site            order(102..103,136,180,183,196..197,237..240,245,248..249,
                     252..258)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410321"
     Region          1041..1082
                     /region_name="MGA_dom"
                     /note="MGA, conserved domain; pfam16059"
                     /db_xref="CDD:464998"
     Region          2265..2329
                     /region_name="bHLHzip_MGA"
                     /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain
                     found in MAX gene-associated protein (MGA) and similar
                     proteins; cd18911"
                     /db_xref="CDD:381481"
     Site            order(2265,2267..2269,2271..2273,2275..2276,2280,
                     2299..2300)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381481"
     Site            order(2279,2282..2283,2285..2286,2289..2291,2301,
                     2304..2305,2308,2310..2312,2314..2315,2317..2318,2321,
                     2324..2325,2328..2329)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381481"
     CDS             1..2905
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /coded_by="XM_047432287.1:189..8906"
                     /db_xref="GeneID:23269"
                     /db_xref="HGNC:HGNC:14010"
                     /db_xref="MIM:616061"
ORIGIN      
        1 meekqqiila nqdggtvaga aptffvilkq pgngktdqgi lvtnqdacal assvsspvks
       61 kgkiclpadc tvggitvtld nnsmwnefyh rstemiltkq grrmfpycry witgldsnlk
      121 yilvmdispv dnhrykwngr wwepsgkaep hvlgrvfihp espstghywm hqpvsfyklk
      181 ltnntldqeg hiilhsmhry lprlhlvpae kaveviqlng pgvhtftfpq teffavtayq
      241 niqitqlkid ynpfakgfrd dglnnkpqrd gkqknssdqe gnnissssgh rvrltegqgs
      301 eiqpgdldpl srghetsgkg lektslnikr dflgfmdtds alsevpqlkq eisecliass
      361 feddsrvasp ldqngsfnvv ikeeplddyd yelgecpegv tvkqeetdee tdvysnsddd
      421 pilekqlkrh nkvdnpeadh lsskwlpssp sgvakakmfk ldtgkmpvvy lepcavtrst
      481 vkiselpdnm lstsrkdkss mlaeleylpt yiensnetaf clgkesengl rkhspdlrvv
      541 qkypllkepq wkypdisdsi sterilddsk dsvgdslsgk edlgrkrttm lkiataakvv
      601 nanqnaspnv pgkrgrprkl klckagrppk ntgkslistk ntpvspgstf pdvkpdledv
      661 dgvlfvsfes kealdihavd gtteessslq asttndsgyr arisqlekel iedlktlrhk
      721 qvihpglqev glklnsvdpt msidlkylgv qlplapatsf pfwnltgtnp aspdagfpfv
      781 srtgktndft kikgwrgkfh sasasrnegg nsesslknrs afcsdkldey lenegklmet
      841 smgfssnapt spvvyqlptk stsyvrtlds vlkkqstisp stsyslkphs vppvsrkaks
      901 qnrqatfsgr tkssyksilp ypvspkqkys hvilgdkvtk nssgiisenq annfvvptld
      961 enifpkqisl rqaqqqqqqq qgsrppglsk sqvklmdled calwegkprt yiteeradvs
     1021 lttlltaqas lktkpihtii rkrappcnnd fcrlgcvcss lalekrqpah crrpdcmfgc
     1081 tclkrkvvlv kggsktkhfq rkaahrdpvf ydtlgeeare eeegireeee qlkekkkrkk
     1141 leyticetep eqpvrhyplw vkvegevdpe pvyiptpsvi epmkplllpq pevlsptvkg
     1201 klltgikspr sytpkpnpvi reedkdpvyl yfesmmtcar vrvyerkked qrqpsssssp
     1261 spsfqqqtsc hsspenhnna kepdseqqpl kqltcdledd sdklqekswk sscnegesss
     1321 tsymhqrspg gptklieiis dcnweedrnk ilsilsqhin snmpqslkvg sfiielasqr
     1381 ksrgeknppv yssrvkismp scqdqddmae ksgsetpdgp lspgkmedis pvqtdaldsv
     1441 rerlhggkgl pfyaglspag klvaykrkps sstsgliqvn gksypqakll lgqmgalhpa
     1501 nrlaayitgr lrpsvldlst lstviskvas nakvaasrkp rtllpstsns kmasssgtat
     1561 nrpgknlkaf vpakrpiena aqipvatpqv spntvkragp rlllipvqqg sptlrpvsnt
     1621 qlqghrmvlq pvrspsgmnl frhpngqivq llplhqlrgs ntqpnlqpvm frnpgsvmgi
     1681 rlpapskpse tppsstsssa fsvmnpviqa vgsssavnvi tqapsllssg asfvsqagtl
     1741 tlrisppepq sfasktgset kityssggqp vgtasliplq sgsfallqlp gqkpvpssil
     1801 qhvaslqmkr esqnpdqkde tnsikreqet kkvlqsegea vdpeanvikq nsgaatseet
     1861 lndsledrgd hldeeclpee gcatvkpseh scitgshtdq dykdvneeyg arnrksskek
     1921 vavlevrtis ekasnktvqn lskvqhqklg dvkveqqkgf dnpeenssef pvtfkeeskf
     1981 elsgskvmeq qsnlqpeake kecgdslekd rerwrkhlkg pltrkcvgas qeckkeadeq
     2041 liketktcqe nsdvfqqeqg isdllgksgi tedarvlkte cdswsrisnp safsivprra
     2101 akssrgnghf qghlllpgeq iqpkqekkgg rssadftvld leeddeddne ktddsideiv
     2161 dvvsdyqsee vddveknncv eyieddeehv dietveelse einvahlktt aahtqsfkqp
     2221 scthisadek aaersrkapp iplklkpdyw sdklqkeaea fayyrrthta nerrrrgemr
     2281 dlfeklkitl gllhsskvsk sliltrafse iqgltdqadk ligqknlltr krnilirkvs
     2341 slsgkteevv lkkleyiyak qqaleaqkrk kkmgsdefdi spriskqqeg ssassvdlgq
     2401 mfinnrrgkp lilsrkkdqa tentsplntp htsanlvmtp qgqlltlkgp lfsgpvvavs
     2461 pdllesdlkp qvagsavalp enddlfmmpr ivnvtslate gglvdmggsk yphevpdskp
     2521 sdhlkdtvrn ednsledkgr issrgnrdgr vtlgptqvfl ankdsgypqi vdvsnmqkaq
     2581 eflpkkisgd mrgiqykwke sesrgervks kdssfhklkm kdlkdssiem elrkvtsaie
     2641 eaaldssell tnmededdtd etltsllnei aflnqqlndd svglaelpss mdtefpgdar
     2701 rafiskvppg sratfqvehl gtglkelpdv qgesdsispl llhledddfs enekqlaepa
     2761 sepdvlkivi dseikdslls nkkaidggkn tsglpaepes vsspptlhmk tglensnstd
     2821 tlwrpmpkla plglkvanps sdadgqslkv mpclapiaak vgsvghkmnl tgndqegres
     2881 kvmptlapvv aklgnsgasp ssagk
//
LOCUS       XP_047288244            2905 aa            linear   PRI 05-AUG-2025
DEFINITION  MAX gene-associated protein isoform X10 [Homo sapiens].
ACCESSION   XP_047288244
VERSION     XP_047288244.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432288.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2905
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2905
                     /product="MAX gene-associated protein isoform X10"
                     /calculated_mol_wt=320292
     Region          75..260
                     /region_name="T-box_MGA-like"
                     /note="DNA-binding domain of MAX gene-associated protein
                     and related T-box proteins; cd20195"
                     /db_xref="CDD:410321"
     Site            order(102..103,136,180,183,196..197,237..240,245,248..249,
                     252..258)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410321"
     Region          1041..1082
                     /region_name="MGA_dom"
                     /note="MGA, conserved domain; pfam16059"
                     /db_xref="CDD:464998"
     Region          2265..2329
                     /region_name="bHLHzip_MGA"
                     /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain
                     found in MAX gene-associated protein (MGA) and similar
                     proteins; cd18911"
                     /db_xref="CDD:381481"
     Site            order(2265,2267..2269,2271..2273,2275..2276,2280,
                     2299..2300)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381481"
     Site            order(2279,2282..2283,2285..2286,2289..2291,2301,
                     2304..2305,2308,2310..2312,2314..2315,2317..2318,2321,
                     2324..2325,2328..2329)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381481"
     CDS             1..2905
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /coded_by="XM_047432288.1:143..8860"
                     /db_xref="GeneID:23269"
                     /db_xref="HGNC:HGNC:14010"
                     /db_xref="MIM:616061"
ORIGIN      
        1 meekqqiila nqdggtvaga aptffvilkq pgngktdqgi lvtnqdacal assvsspvks
       61 kgkiclpadc tvggitvtld nnsmwnefyh rstemiltkq grrmfpycry witgldsnlk
      121 yilvmdispv dnhrykwngr wwepsgkaep hvlgrvfihp espstghywm hqpvsfyklk
      181 ltnntldqeg hiilhsmhry lprlhlvpae kaveviqlng pgvhtftfpq teffavtayq
      241 niqitqlkid ynpfakgfrd dglnnkpqrd gkqknssdqe gnnissssgh rvrltegqgs
      301 eiqpgdldpl srghetsgkg lektslnikr dflgfmdtds alsevpqlkq eisecliass
      361 feddsrvasp ldqngsfnvv ikeeplddyd yelgecpegv tvkqeetdee tdvysnsddd
      421 pilekqlkrh nkvdnpeadh lsskwlpssp sgvakakmfk ldtgkmpvvy lepcavtrst
      481 vkiselpdnm lstsrkdkss mlaeleylpt yiensnetaf clgkesengl rkhspdlrvv
      541 qkypllkepq wkypdisdsi sterilddsk dsvgdslsgk edlgrkrttm lkiataakvv
      601 nanqnaspnv pgkrgrprkl klckagrppk ntgkslistk ntpvspgstf pdvkpdledv
      661 dgvlfvsfes kealdihavd gtteessslq asttndsgyr arisqlekel iedlktlrhk
      721 qvihpglqev glklnsvdpt msidlkylgv qlplapatsf pfwnltgtnp aspdagfpfv
      781 srtgktndft kikgwrgkfh sasasrnegg nsesslknrs afcsdkldey lenegklmet
      841 smgfssnapt spvvyqlptk stsyvrtlds vlkkqstisp stsyslkphs vppvsrkaks
      901 qnrqatfsgr tkssyksilp ypvspkqkys hvilgdkvtk nssgiisenq annfvvptld
      961 enifpkqisl rqaqqqqqqq qgsrppglsk sqvklmdled calwegkprt yiteeradvs
     1021 lttlltaqas lktkpihtii rkrappcnnd fcrlgcvcss lalekrqpah crrpdcmfgc
     1081 tclkrkvvlv kggsktkhfq rkaahrdpvf ydtlgeeare eeegireeee qlkekkkrkk
     1141 leyticetep eqpvrhyplw vkvegevdpe pvyiptpsvi epmkplllpq pevlsptvkg
     1201 klltgikspr sytpkpnpvi reedkdpvyl yfesmmtcar vrvyerkked qrqpsssssp
     1261 spsfqqqtsc hsspenhnna kepdseqqpl kqltcdledd sdklqekswk sscnegesss
     1321 tsymhqrspg gptklieiis dcnweedrnk ilsilsqhin snmpqslkvg sfiielasqr
     1381 ksrgeknppv yssrvkismp scqdqddmae ksgsetpdgp lspgkmedis pvqtdaldsv
     1441 rerlhggkgl pfyaglspag klvaykrkps sstsgliqvn gksypqakll lgqmgalhpa
     1501 nrlaayitgr lrpsvldlst lstviskvas nakvaasrkp rtllpstsns kmasssgtat
     1561 nrpgknlkaf vpakrpiena aqipvatpqv spntvkragp rlllipvqqg sptlrpvsnt
     1621 qlqghrmvlq pvrspsgmnl frhpngqivq llplhqlrgs ntqpnlqpvm frnpgsvmgi
     1681 rlpapskpse tppsstsssa fsvmnpviqa vgsssavnvi tqapsllssg asfvsqagtl
     1741 tlrisppepq sfasktgset kityssggqp vgtasliplq sgsfallqlp gqkpvpssil
     1801 qhvaslqmkr esqnpdqkde tnsikreqet kkvlqsegea vdpeanvikq nsgaatseet
     1861 lndsledrgd hldeeclpee gcatvkpseh scitgshtdq dykdvneeyg arnrksskek
     1921 vavlevrtis ekasnktvqn lskvqhqklg dvkveqqkgf dnpeenssef pvtfkeeskf
     1981 elsgskvmeq qsnlqpeake kecgdslekd rerwrkhlkg pltrkcvgas qeckkeadeq
     2041 liketktcqe nsdvfqqeqg isdllgksgi tedarvlkte cdswsrisnp safsivprra
     2101 akssrgnghf qghlllpgeq iqpkqekkgg rssadftvld leeddeddne ktddsideiv
     2161 dvvsdyqsee vddveknncv eyieddeehv dietveelse einvahlktt aahtqsfkqp
     2221 scthisadek aaersrkapp iplklkpdyw sdklqkeaea fayyrrthta nerrrrgemr
     2281 dlfeklkitl gllhsskvsk sliltrafse iqgltdqadk ligqknlltr krnilirkvs
     2341 slsgkteevv lkkleyiyak qqaleaqkrk kkmgsdefdi spriskqqeg ssassvdlgq
     2401 mfinnrrgkp lilsrkkdqa tentsplntp htsanlvmtp qgqlltlkgp lfsgpvvavs
     2461 pdllesdlkp qvagsavalp enddlfmmpr ivnvtslate gglvdmggsk yphevpdskp
     2521 sdhlkdtvrn ednsledkgr issrgnrdgr vtlgptqvfl ankdsgypqi vdvsnmqkaq
     2581 eflpkkisgd mrgiqykwke sesrgervks kdssfhklkm kdlkdssiem elrkvtsaie
     2641 eaaldssell tnmededdtd etltsllnei aflnqqlndd svglaelpss mdtefpgdar
     2701 rafiskvppg sratfqvehl gtglkelpdv qgesdsispl llhledddfs enekqlaepa
     2761 sepdvlkivi dseikdslls nkkaidggkn tsglpaepes vsspptlhmk tglensnstd
     2821 tlwrpmpkla plglkvanps sdadgqslkv mpclapiaak vgsvghkmnl tgndqegres
     2881 kvmptlapvv aklgnsgasp ssagk
//
LOCUS       XP_047288245            2905 aa            linear   PRI 05-AUG-2025
DEFINITION  MAX gene-associated protein isoform X10 [Homo sapiens].
ACCESSION   XP_047288245
VERSION     XP_047288245.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432289.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2905
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2905
                     /product="MAX gene-associated protein isoform X10"
                     /calculated_mol_wt=320292
     Region          75..260
                     /region_name="T-box_MGA-like"
                     /note="DNA-binding domain of MAX gene-associated protein
                     and related T-box proteins; cd20195"
                     /db_xref="CDD:410321"
     Site            order(102..103,136,180,183,196..197,237..240,245,248..249,
                     252..258)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410321"
     Region          1041..1082
                     /region_name="MGA_dom"
                     /note="MGA, conserved domain; pfam16059"
                     /db_xref="CDD:464998"
     Region          2265..2329
                     /region_name="bHLHzip_MGA"
                     /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain
                     found in MAX gene-associated protein (MGA) and similar
                     proteins; cd18911"
                     /db_xref="CDD:381481"
     Site            order(2265,2267..2269,2271..2273,2275..2276,2280,
                     2299..2300)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381481"
     Site            order(2279,2282..2283,2285..2286,2289..2291,2301,
                     2304..2305,2308,2310..2312,2314..2315,2317..2318,2321,
                     2324..2325,2328..2329)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381481"
     CDS             1..2905
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /coded_by="XM_047432289.1:165..8882"
                     /db_xref="GeneID:23269"
                     /db_xref="HGNC:HGNC:14010"
                     /db_xref="MIM:616061"
ORIGIN      
        1 meekqqiila nqdggtvaga aptffvilkq pgngktdqgi lvtnqdacal assvsspvks
       61 kgkiclpadc tvggitvtld nnsmwnefyh rstemiltkq grrmfpycry witgldsnlk
      121 yilvmdispv dnhrykwngr wwepsgkaep hvlgrvfihp espstghywm hqpvsfyklk
      181 ltnntldqeg hiilhsmhry lprlhlvpae kaveviqlng pgvhtftfpq teffavtayq
      241 niqitqlkid ynpfakgfrd dglnnkpqrd gkqknssdqe gnnissssgh rvrltegqgs
      301 eiqpgdldpl srghetsgkg lektslnikr dflgfmdtds alsevpqlkq eisecliass
      361 feddsrvasp ldqngsfnvv ikeeplddyd yelgecpegv tvkqeetdee tdvysnsddd
      421 pilekqlkrh nkvdnpeadh lsskwlpssp sgvakakmfk ldtgkmpvvy lepcavtrst
      481 vkiselpdnm lstsrkdkss mlaeleylpt yiensnetaf clgkesengl rkhspdlrvv
      541 qkypllkepq wkypdisdsi sterilddsk dsvgdslsgk edlgrkrttm lkiataakvv
      601 nanqnaspnv pgkrgrprkl klckagrppk ntgkslistk ntpvspgstf pdvkpdledv
      661 dgvlfvsfes kealdihavd gtteessslq asttndsgyr arisqlekel iedlktlrhk
      721 qvihpglqev glklnsvdpt msidlkylgv qlplapatsf pfwnltgtnp aspdagfpfv
      781 srtgktndft kikgwrgkfh sasasrnegg nsesslknrs afcsdkldey lenegklmet
      841 smgfssnapt spvvyqlptk stsyvrtlds vlkkqstisp stsyslkphs vppvsrkaks
      901 qnrqatfsgr tkssyksilp ypvspkqkys hvilgdkvtk nssgiisenq annfvvptld
      961 enifpkqisl rqaqqqqqqq qgsrppglsk sqvklmdled calwegkprt yiteeradvs
     1021 lttlltaqas lktkpihtii rkrappcnnd fcrlgcvcss lalekrqpah crrpdcmfgc
     1081 tclkrkvvlv kggsktkhfq rkaahrdpvf ydtlgeeare eeegireeee qlkekkkrkk
     1141 leyticetep eqpvrhyplw vkvegevdpe pvyiptpsvi epmkplllpq pevlsptvkg
     1201 klltgikspr sytpkpnpvi reedkdpvyl yfesmmtcar vrvyerkked qrqpsssssp
     1261 spsfqqqtsc hsspenhnna kepdseqqpl kqltcdledd sdklqekswk sscnegesss
     1321 tsymhqrspg gptklieiis dcnweedrnk ilsilsqhin snmpqslkvg sfiielasqr
     1381 ksrgeknppv yssrvkismp scqdqddmae ksgsetpdgp lspgkmedis pvqtdaldsv
     1441 rerlhggkgl pfyaglspag klvaykrkps sstsgliqvn gksypqakll lgqmgalhpa
     1501 nrlaayitgr lrpsvldlst lstviskvas nakvaasrkp rtllpstsns kmasssgtat
     1561 nrpgknlkaf vpakrpiena aqipvatpqv spntvkragp rlllipvqqg sptlrpvsnt
     1621 qlqghrmvlq pvrspsgmnl frhpngqivq llplhqlrgs ntqpnlqpvm frnpgsvmgi
     1681 rlpapskpse tppsstsssa fsvmnpviqa vgsssavnvi tqapsllssg asfvsqagtl
     1741 tlrisppepq sfasktgset kityssggqp vgtasliplq sgsfallqlp gqkpvpssil
     1801 qhvaslqmkr esqnpdqkde tnsikreqet kkvlqsegea vdpeanvikq nsgaatseet
     1861 lndsledrgd hldeeclpee gcatvkpseh scitgshtdq dykdvneeyg arnrksskek
     1921 vavlevrtis ekasnktvqn lskvqhqklg dvkveqqkgf dnpeenssef pvtfkeeskf
     1981 elsgskvmeq qsnlqpeake kecgdslekd rerwrkhlkg pltrkcvgas qeckkeadeq
     2041 liketktcqe nsdvfqqeqg isdllgksgi tedarvlkte cdswsrisnp safsivprra
     2101 akssrgnghf qghlllpgeq iqpkqekkgg rssadftvld leeddeddne ktddsideiv
     2161 dvvsdyqsee vddveknncv eyieddeehv dietveelse einvahlktt aahtqsfkqp
     2221 scthisadek aaersrkapp iplklkpdyw sdklqkeaea fayyrrthta nerrrrgemr
     2281 dlfeklkitl gllhsskvsk sliltrafse iqgltdqadk ligqknlltr krnilirkvs
     2341 slsgkteevv lkkleyiyak qqaleaqkrk kkmgsdefdi spriskqqeg ssassvdlgq
     2401 mfinnrrgkp lilsrkkdqa tentsplntp htsanlvmtp qgqlltlkgp lfsgpvvavs
     2461 pdllesdlkp qvagsavalp enddlfmmpr ivnvtslate gglvdmggsk yphevpdskp
     2521 sdhlkdtvrn ednsledkgr issrgnrdgr vtlgptqvfl ankdsgypqi vdvsnmqkaq
     2581 eflpkkisgd mrgiqykwke sesrgervks kdssfhklkm kdlkdssiem elrkvtsaie
     2641 eaaldssell tnmededdtd etltsllnei aflnqqlndd svglaelpss mdtefpgdar
     2701 rafiskvppg sratfqvehl gtglkelpdv qgesdsispl llhledddfs enekqlaepa
     2761 sepdvlkivi dseikdslls nkkaidggkn tsglpaepes vsspptlhmk tglensnstd
     2821 tlwrpmpkla plglkvanps sdadgqslkv mpclapiaak vgsvghkmnl tgndqegres
     2881 kvmptlapvv aklgnsgasp ssagk
//
LOCUS       XP_047288246            2857 aa            linear   PRI 05-AUG-2025
DEFINITION  MAX gene-associated protein isoform X11 [Homo sapiens].
ACCESSION   XP_047288246
VERSION     XP_047288246.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432290.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2857
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2857
                     /product="MAX gene-associated protein isoform X11"
                     /calculated_mol_wt=315188
     Region          75..260
                     /region_name="T-box_MGA-like"
                     /note="DNA-binding domain of MAX gene-associated protein
                     and related T-box proteins; cd20195"
                     /db_xref="CDD:410321"
     Site            order(102..103,136,180,183,196..197,237..240,245,248..249,
                     252..258)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410321"
     Region          1041..1082
                     /region_name="MGA_dom"
                     /note="MGA, conserved domain; pfam16059"
                     /db_xref="CDD:464998"
     Region          2217..2281
                     /region_name="bHLHzip_MGA"
                     /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain
                     found in MAX gene-associated protein (MGA) and similar
                     proteins; cd18911"
                     /db_xref="CDD:381481"
     Site            order(2217,2219..2221,2223..2225,2227..2228,2232,
                     2251..2252)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381481"
     Site            order(2231,2234..2235,2237..2238,2241..2243,2253,
                     2256..2257,2260,2262..2264,2266..2267,2269..2270,2273,
                     2276..2277,2280..2281)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381481"
     CDS             1..2857
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /coded_by="XM_047432290.1:189..8762"
                     /db_xref="GeneID:23269"
                     /db_xref="HGNC:HGNC:14010"
                     /db_xref="MIM:616061"
ORIGIN      
        1 meekqqiila nqdggtvaga aptffvilkq pgngktdqgi lvtnqdacal assvsspvks
       61 kgkiclpadc tvggitvtld nnsmwnefyh rstemiltkq grrmfpycry witgldsnlk
      121 yilvmdispv dnhrykwngr wwepsgkaep hvlgrvfihp espstghywm hqpvsfyklk
      181 ltnntldqeg hiilhsmhry lprlhlvpae kaveviqlng pgvhtftfpq teffavtayq
      241 niqitqlkid ynpfakgfrd dglnnkpqrd gkqknssdqe gnnissssgh rvrltegqgs
      301 eiqpgdldpl srghetsgkg lektslnikr dflgfmdtds alsevpqlkq eisecliass
      361 feddsrvasp ldqngsfnvv ikeeplddyd yelgecpegv tvkqeetdee tdvysnsddd
      421 pilekqlkrh nkvdnpeadh lsskwlpssp sgvakakmfk ldtgkmpvvy lepcavtrst
      481 vkiselpdnm lstsrkdkss mlaeleylpt yiensnetaf clgkesengl rkhspdlrvv
      541 qkypllkepq wkypdisdsi sterilddsk dsvgdslsgk edlgrkrttm lkiataakvv
      601 nanqnaspnv pgkrgrprkl klckagrppk ntgkslistk ntpvspgstf pdvkpdledv
      661 dgvlfvsfes kealdihavd gtteessslq asttndsgyr arisqlekel iedlktlrhk
      721 qvihpglqev glklnsvdpt msidlkylgv qlplapatsf pfwnltgtnp aspdagfpfv
      781 srtgktndft kikgwrgkfh sasasrnegg nsesslknrs afcsdkldey lenegklmet
      841 smgfssnapt spvvyqlptk stsyvrtlds vlkkqstisp stsyslkphs vppvsrkaks
      901 qnrqatfsgr tkssyksilp ypvspkqkys hvilgdkvtk nssgiisenq annfvvptld
      961 enifpkqisl rqaqqqqqqq qgsrppglsk sqvklmdled calwegkprt yiteeradvs
     1021 lttlltaqas lktkpihtii rkrappcnnd fcrlgcvcss lalekrqpah crrpdcmfgc
     1081 tclkrkvvlv kggsktkhfq rkaahrdpvf ydtlgeeare eeegireeee qlkekkkrkk
     1141 leyticetep eqpvrhyplw vkvegevdpe pvyiptpsvi epmkplllpq pevlsptvkg
     1201 klltgikspr sytpkpnpvi reedkdpvyl yfesmmtcar vrvyerkked qrqpsssssp
     1261 spsfqqqtsc hsspenhnna kepdseqqpl kqltcdledd sdklqekswk sscnegesss
     1321 tsymhqrspg gptklieiis dcnweedrnk ilsilsqhin snmpqslkvg sfiielasqr
     1381 ksrgeknppv yssrvkismp scqdqddmae ksgsetpdgp lspgkmedis pvqtdaldsv
     1441 rerlhggkgl pfyaglspag klvaykrkps sstsgliqva snakvaasrk prtllpstsn
     1501 skmasssgta tnrpgknlka fvpakrpien aaqipvatpq vspntvkrag prlllipvqq
     1561 gsptlrpvsn tqlqghrmvl qpvrspsgmn lfrhpngqiv qllplhqlrg sntqpnlqpv
     1621 mfrnpgsvmg irlpapskps etppsstsss afsvmnpviq avgsssavnv itqapsllss
     1681 gasfvsqagt ltlrisppep qsfasktgse tkityssggq pvgtaslipl qsgsfallql
     1741 pgqkpvpssi lqhvaslqmk resqnpdqkd etnsikreqe tkkvlqsege avdpeanvik
     1801 qnsgaatsee tlndsledrg dhldeeclpe egcatvkpse hscitgshtd qdykdvneey
     1861 garnrksske kvavlevrti sekasnktvq nlskvqhqkl gdvkveqqkg fdnpeensse
     1921 fpvtfkeesk felsgskvme qqsnlqpeak ekecgdslek drerwrkhlk gpltrkcvga
     1981 sqeckkeade qliketktcq ensdvfqqeq gisdllgksg itedarvlkt ecdswsrisn
     2041 psafsivprr aakssrgngh fqghlllpge qiqpkqekkg grssadftvl dleeddeddn
     2101 ektddsidei vdvvsdyqse evddvekvnn cveyieddee hvdietveel seeinvahlk
     2161 ttaahtqsfk qpscthisad ekaaersrka ppiplklkpd ywsdklqkea eafayyrrth
     2221 tanerrrrge mrdlfeklki tlgllhsskv sksliltraf seiqgltdqa dkligqknll
     2281 trkrnilirk vsslsgktee vvlkkleyiy akqqaleaqk rkkkmgsdef dispriskqq
     2341 egssassvdl gqmfinnrrg kplilsrkkd qatentspln tphtsanlvm tpqgqlltlk
     2401 gplfsgpvva vspdllesdl kpqvagsava lpenddlfmm privnvtsla tegglvdmgg
     2461 skyphevpds kpsdhlkdtv rnednsledk grissrgnrd grvtlgptqv flankdsgyp
     2521 qivdvsnmqk aqeflpkkis gdmrgiqykw kesesrgerv kskdssfhkl kmkdlkdssi
     2581 emelrkvtsa ieeaaldsse lltnmededd tdetltslln eiaflnqqln ddsvglaelp
     2641 ssmdtefpgd arrafiskvp pgsratfqve hlgtglkelp dvqgesdsis plllhleddd
     2701 fsenekqlae pasepdvlki vidseikdsl lsnkkaidgg kntsglpaep esvsspptlh
     2761 mktglensns tdtlwrpmpk laplglkvan pssdadgqsl kvmpclapia akvgsvghkm
     2821 nltgndqegr eskvmptlap vvaklgnsga spssagk
//
LOCUS       XP_047288247            2856 aa            linear   PRI 05-AUG-2025
DEFINITION  MAX gene-associated protein isoform X12 [Homo sapiens].
ACCESSION   XP_047288247
VERSION     XP_047288247.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432291.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2856
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2856
                     /product="MAX gene-associated protein isoform X12"
                     /calculated_mol_wt=315089
     Region          75..260
                     /region_name="T-box_MGA-like"
                     /note="DNA-binding domain of MAX gene-associated protein
                     and related T-box proteins; cd20195"
                     /db_xref="CDD:410321"
     Site            order(102..103,136,180,183,196..197,237..240,245,248..249,
                     252..258)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410321"
     Region          1041..1082
                     /region_name="MGA_dom"
                     /note="MGA, conserved domain; pfam16059"
                     /db_xref="CDD:464998"
     Region          2216..2280
                     /region_name="bHLHzip_MGA"
                     /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain
                     found in MAX gene-associated protein (MGA) and similar
                     proteins; cd18911"
                     /db_xref="CDD:381481"
     Site            order(2216,2218..2220,2222..2224,2226..2227,2231,
                     2250..2251)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381481"
     Site            order(2230,2233..2234,2236..2237,2240..2242,2252,
                     2255..2256,2259,2261..2263,2265..2266,2268..2269,2272,
                     2275..2276,2279..2280)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381481"
     CDS             1..2856
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /coded_by="XM_047432291.1:143..8713"
                     /db_xref="GeneID:23269"
                     /db_xref="HGNC:HGNC:14010"
                     /db_xref="MIM:616061"
ORIGIN      
        1 meekqqiila nqdggtvaga aptffvilkq pgngktdqgi lvtnqdacal assvsspvks
       61 kgkiclpadc tvggitvtld nnsmwnefyh rstemiltkq grrmfpycry witgldsnlk
      121 yilvmdispv dnhrykwngr wwepsgkaep hvlgrvfihp espstghywm hqpvsfyklk
      181 ltnntldqeg hiilhsmhry lprlhlvpae kaveviqlng pgvhtftfpq teffavtayq
      241 niqitqlkid ynpfakgfrd dglnnkpqrd gkqknssdqe gnnissssgh rvrltegqgs
      301 eiqpgdldpl srghetsgkg lektslnikr dflgfmdtds alsevpqlkq eisecliass
      361 feddsrvasp ldqngsfnvv ikeeplddyd yelgecpegv tvkqeetdee tdvysnsddd
      421 pilekqlkrh nkvdnpeadh lsskwlpssp sgvakakmfk ldtgkmpvvy lepcavtrst
      481 vkiselpdnm lstsrkdkss mlaeleylpt yiensnetaf clgkesengl rkhspdlrvv
      541 qkypllkepq wkypdisdsi sterilddsk dsvgdslsgk edlgrkrttm lkiataakvv
      601 nanqnaspnv pgkrgrprkl klckagrppk ntgkslistk ntpvspgstf pdvkpdledv
      661 dgvlfvsfes kealdihavd gtteessslq asttndsgyr arisqlekel iedlktlrhk
      721 qvihpglqev glklnsvdpt msidlkylgv qlplapatsf pfwnltgtnp aspdagfpfv
      781 srtgktndft kikgwrgkfh sasasrnegg nsesslknrs afcsdkldey lenegklmet
      841 smgfssnapt spvvyqlptk stsyvrtlds vlkkqstisp stsyslkphs vppvsrkaks
      901 qnrqatfsgr tkssyksilp ypvspkqkys hvilgdkvtk nssgiisenq annfvvptld
      961 enifpkqisl rqaqqqqqqq qgsrppglsk sqvklmdled calwegkprt yiteeradvs
     1021 lttlltaqas lktkpihtii rkrappcnnd fcrlgcvcss lalekrqpah crrpdcmfgc
     1081 tclkrkvvlv kggsktkhfq rkaahrdpvf ydtlgeeare eeegireeee qlkekkkrkk
     1141 leyticetep eqpvrhyplw vkvegevdpe pvyiptpsvi epmkplllpq pevlsptvkg
     1201 klltgikspr sytpkpnpvi reedkdpvyl yfesmmtcar vrvyerkked qrqpsssssp
     1261 spsfqqqtsc hsspenhnna kepdseqqpl kqltcdledd sdklqekswk sscnegesss
     1321 tsymhqrspg gptklieiis dcnweedrnk ilsilsqhin snmpqslkvg sfiielasqr
     1381 ksrgeknppv yssrvkismp scqdqddmae ksgsetpdgp lspgkmedis pvqtdaldsv
     1441 rerlhggkgl pfyaglspag klvaykrkps sstsgliqva snakvaasrk prtllpstsn
     1501 skmasssgta tnrpgknlka fvpakrpien aaqipvatpq vspntvkrag prlllipvqq
     1561 gsptlrpvsn tqlqghrmvl qpvrspsgmn lfrhpngqiv qllplhqlrg sntqpnlqpv
     1621 mfrnpgsvmg irlpapskps etppsstsss afsvmnpviq avgsssavnv itqapsllss
     1681 gasfvsqagt ltlrisppep qsfasktgse tkityssggq pvgtaslipl qsgsfallql
     1741 pgqkpvpssi lqhvaslqmk resqnpdqkd etnsikreqe tkkvlqsege avdpeanvik
     1801 qnsgaatsee tlndsledrg dhldeeclpe egcatvkpse hscitgshtd qdykdvneey
     1861 garnrksske kvavlevrti sekasnktvq nlskvqhqkl gdvkveqqkg fdnpeensse
     1921 fpvtfkeesk felsgskvme qqsnlqpeak ekecgdslek drerwrkhlk gpltrkcvga
     1981 sqeckkeade qliketktcq ensdvfqqeq gisdllgksg itedarvlkt ecdswsrisn
     2041 psafsivprr aakssrgngh fqghlllpge qiqpkqekkg grssadftvl dleeddeddn
     2101 ektddsidei vdvvsdyqse evddveknnc veyieddeeh vdietveels eeinvahlkt
     2161 taahtqsfkq pscthisade kaaersrkap piplklkpdy wsdklqkeae afayyrrtht
     2221 anerrrrgem rdlfeklkit lgllhsskvs ksliltrafs eiqgltdqad kligqknllt
     2281 rkrnilirkv sslsgkteev vlkkleyiya kqqaleaqkr kkkmgsdefd ispriskqqe
     2341 gssassvdlg qmfinnrrgk plilsrkkdq atentsplnt phtsanlvmt pqgqlltlkg
     2401 plfsgpvvav spdllesdlk pqvagsaval penddlfmmp rivnvtslat egglvdmggs
     2461 kyphevpdsk psdhlkdtvr nednsledkg rissrgnrdg rvtlgptqvf lankdsgypq
     2521 ivdvsnmqka qeflpkkisg dmrgiqykwk esesrgervk skdssfhklk mkdlkdssie
     2581 melrkvtsai eeaaldssel ltnmededdt detltsllne iaflnqqlnd dsvglaelps
     2641 smdtefpgda rrafiskvpp gsratfqveh lgtglkelpd vqgesdsisp lllhledddf
     2701 senekqlaep asepdvlkiv idseikdsll snkkaidggk ntsglpaepe svsspptlhm
     2761 ktglensnst dtlwrpmpkl aplglkvanp ssdadgqslk vmpclapiaa kvgsvghkmn
     2821 ltgndqegre skvmptlapv vaklgnsgas pssagk
//
LOCUS       XP_047288248            2796 aa            linear   PRI 05-AUG-2025
DEFINITION  MAX gene-associated protein isoform X13 [Homo sapiens].
ACCESSION   XP_047288248
VERSION     XP_047288248.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432292.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2796
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2796
                     /product="MAX gene-associated protein isoform X13"
                     /calculated_mol_wt=308673
     Region          75..260
                     /region_name="T-box_MGA-like"
                     /note="DNA-binding domain of MAX gene-associated protein
                     and related T-box proteins; cd20195"
                     /db_xref="CDD:410321"
     Site            order(102..103,136,180,183,196..197,237..240,245,248..249,
                     252..258)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410321"
     Region          1041..1082
                     /region_name="MGA_dom"
                     /note="MGA, conserved domain; pfam16059"
                     /db_xref="CDD:464998"
     Region          2156..2220
                     /region_name="bHLHzip_MGA"
                     /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain
                     found in MAX gene-associated protein (MGA) and similar
                     proteins; cd18911"
                     /db_xref="CDD:381481"
     Site            order(2156,2158..2160,2162..2164,2166..2167,2171,
                     2190..2191)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381481"
     Site            order(2170,2173..2174,2176..2177,2180..2182,2192,
                     2195..2196,2199,2201..2203,2205..2206,2208..2209,2212,
                     2215..2216,2219..2220)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381481"
     CDS             1..2796
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /coded_by="XM_047432292.1:189..8579"
                     /db_xref="GeneID:23269"
                     /db_xref="HGNC:HGNC:14010"
                     /db_xref="MIM:616061"
ORIGIN      
        1 meekqqiila nqdggtvaga aptffvilkq pgngktdqgi lvtnqdacal assvsspvks
       61 kgkiclpadc tvggitvtld nnsmwnefyh rstemiltkq grrmfpycry witgldsnlk
      121 yilvmdispv dnhrykwngr wwepsgkaep hvlgrvfihp espstghywm hqpvsfyklk
      181 ltnntldqeg hiilhsmhry lprlhlvpae kaveviqlng pgvhtftfpq teffavtayq
      241 niqitqlkid ynpfakgfrd dglnnkpqrd gkqknssdqe gnnissssgh rvrltegqgs
      301 eiqpgdldpl srghetsgkg lektslnikr dflgfmdtds alsevpqlkq eisecliass
      361 feddsrvasp ldqngsfnvv ikeeplddyd yelgecpegv tvkqeetdee tdvysnsddd
      421 pilekqlkrh nkvdnpeadh lsskwlpssp sgvakakmfk ldtgkmpvvy lepcavtrst
      481 vkiselpdnm lstsrkdkss mlaeleylpt yiensnetaf clgkesengl rkhspdlrvv
      541 qkypllkepq wkypdisdsi sterilddsk dsvgdslsgk edlgrkrttm lkiataakvv
      601 nanqnaspnv pgkrgrprkl klckagrppk ntgkslistk ntpvspgstf pdvkpdledv
      661 dgvlfvsfes kealdihavd gtteessslq asttndsgyr arisqlekel iedlktlrhk
      721 qvihpglqev glklnsvdpt msidlkylgv qlplapatsf pfwnltgtnp aspdagfpfv
      781 srtgktndft kikgwrgkfh sasasrnegg nsesslknrs afcsdkldey lenegklmet
      841 smgfssnapt spvvyqlptk stsyvrtlds vlkkqstisp stsyslkphs vppvsrkaks
      901 qnrqatfsgr tkssyksilp ypvspkqkys hvilgdkvtk nssgiisenq annfvvptld
      961 enifpkqisl rqaqqqqqqq qgsrppglsk sqvklmdled calwegkprt yiteeradvs
     1021 lttlltaqas lktkpihtii rkrappcnnd fcrlgcvcss lalekrqpah crrpdcmfgc
     1081 tclkrkvvlv kggsktkhfq rkaahrdpvf ydtlgeeare eeegireeee qlkekkkrkk
     1141 leyticetep eqpvrhyplw vkvegevdpe pvyiptpsvi epmkplllpq pevlsptvkg
     1201 klltgikspr sytpkpnpvi reedkdpvyl yfesmmtcar vrvyerkked qrqpsssssp
     1261 spsfqqqtsc hsspenhnna kepdseqqpl kqltcdledd sdklqekswk sscnegesss
     1321 tsymhqrspg gptklieiis dcnweedrnk ilsilsqhin snmpqslkvn gksypqakll
     1381 lgqmgalhpa nrlaayitgr lrpsvldlst lstviskvas nakvaasrkp rtllpstsns
     1441 kmasssgtat nrpgknlkaf vpakrpiena aqipvatpqv spntvkragp rlllipvqqg
     1501 sptlrpvsnt qlqghrmvlq pvrspsgmnl frhpngqivq llplhqlrgs ntqpnlqpvm
     1561 frnpgsvmgi rlpapskpse tppsstsssa fsvmnpviqa vgsssavnvi tqapsllssg
     1621 asfvsqagtl tlrisppepq sfasktgset kityssggqp vgtasliplq sgsfallqlp
     1681 gqkpvpssil qhvaslqmkr esqnpdqkde tnsikreqet kkvlqsegea vdpeanvikq
     1741 nsgaatseet lndsledrgd hldeeclpee gcatvkpseh scitgshtdq dykdvneeyg
     1801 arnrksskek vavlevrtis ekasnktvqn lskvqhqklg dvkveqqkgf dnpeenssef
     1861 pvtfkeeskf elsgskvmeq qsnlqpeake kecgdslekd rerwrkhlkg pltrkcvgas
     1921 qeckkeadeq liketktcqe nsdvfqqeqg isdllgksgi tedarvlkte cdswsrisnp
     1981 safsivprra akssrgnghf qghlllpgeq iqpkqekkgg rssadftvld leeddeddne
     2041 ktddsideiv dvvsdyqsee vddvekvnnc veyieddeeh vdietveels eeinvahlkt
     2101 taahtqsfkq pscthisade kaaersrkap piplklkpdy wsdklqkeae afayyrrtht
     2161 anerrrrgem rdlfeklkit lgllhsskvs ksliltrafs eiqgltdqad kligqknllt
     2221 rkrnilirkv sslsgkteev vlkkleyiya kqqaleaqkr kkkmgsdefd ispriskqqe
     2281 gssassvdlg qmfinnrrgk plilsrkkdq atentsplnt phtsanlvmt pqgqlltlkg
     2341 plfsgpvvav spdllesdlk pqvagsaval penddlfmmp rivnvtslat egglvdmggs
     2401 kyphevpdsk psdhlkdtvr nednsledkg rissrgnrdg rvtlgptqvf lankdsgypq
     2461 ivdvsnmqka qeflpkkisg dmrgiqykwk esesrgervk skdssfhklk mkdlkdssie
     2521 melrkvtsai eeaaldssel ltnmededdt detltsllne iaflnqqlnd dsvglaelps
     2581 smdtefpgda rrafiskvpp gsratfqveh lgtglkelpd vqgesdsisp lllhledddf
     2641 senekqlaep asepdvlkiv idseikdsll snkkaidggk ntsglpaepe svsspptlhm
     2701 ktglensnst dtlwrpmpkl aplglkvanp ssdadgqslk vmpclapiaa kvgsvghkmn
     2761 ltgndqegre skvmptlapv vaklgnsgas pssagk
//
LOCUS       XP_047288249            2795 aa            linear   PRI 05-AUG-2025
DEFINITION  MAX gene-associated protein isoform X14 [Homo sapiens].
ACCESSION   XP_047288249
VERSION     XP_047288249.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432293.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2795
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2795
                     /product="MAX gene-associated protein isoform X14"
                     /calculated_mol_wt=308574
     Region          75..260
                     /region_name="T-box_MGA-like"
                     /note="DNA-binding domain of MAX gene-associated protein
                     and related T-box proteins; cd20195"
                     /db_xref="CDD:410321"
     Site            order(102..103,136,180,183,196..197,237..240,245,248..249,
                     252..258)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410321"
     Region          1041..1082
                     /region_name="MGA_dom"
                     /note="MGA, conserved domain; pfam16059"
                     /db_xref="CDD:464998"
     Region          2155..2219
                     /region_name="bHLHzip_MGA"
                     /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain
                     found in MAX gene-associated protein (MGA) and similar
                     proteins; cd18911"
                     /db_xref="CDD:381481"
     Site            order(2155,2157..2159,2161..2163,2165..2166,2170,
                     2189..2190)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381481"
     Site            order(2169,2172..2173,2175..2176,2179..2181,2191,
                     2194..2195,2198,2200..2202,2204..2205,2207..2208,2211,
                     2214..2215,2218..2219)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381481"
     CDS             1..2795
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /coded_by="XM_047432293.1:189..8576"
                     /db_xref="GeneID:23269"
                     /db_xref="HGNC:HGNC:14010"
                     /db_xref="MIM:616061"
ORIGIN      
        1 meekqqiila nqdggtvaga aptffvilkq pgngktdqgi lvtnqdacal assvsspvks
       61 kgkiclpadc tvggitvtld nnsmwnefyh rstemiltkq grrmfpycry witgldsnlk
      121 yilvmdispv dnhrykwngr wwepsgkaep hvlgrvfihp espstghywm hqpvsfyklk
      181 ltnntldqeg hiilhsmhry lprlhlvpae kaveviqlng pgvhtftfpq teffavtayq
      241 niqitqlkid ynpfakgfrd dglnnkpqrd gkqknssdqe gnnissssgh rvrltegqgs
      301 eiqpgdldpl srghetsgkg lektslnikr dflgfmdtds alsevpqlkq eisecliass
      361 feddsrvasp ldqngsfnvv ikeeplddyd yelgecpegv tvkqeetdee tdvysnsddd
      421 pilekqlkrh nkvdnpeadh lsskwlpssp sgvakakmfk ldtgkmpvvy lepcavtrst
      481 vkiselpdnm lstsrkdkss mlaeleylpt yiensnetaf clgkesengl rkhspdlrvv
      541 qkypllkepq wkypdisdsi sterilddsk dsvgdslsgk edlgrkrttm lkiataakvv
      601 nanqnaspnv pgkrgrprkl klckagrppk ntgkslistk ntpvspgstf pdvkpdledv
      661 dgvlfvsfes kealdihavd gtteessslq asttndsgyr arisqlekel iedlktlrhk
      721 qvihpglqev glklnsvdpt msidlkylgv qlplapatsf pfwnltgtnp aspdagfpfv
      781 srtgktndft kikgwrgkfh sasasrnegg nsesslknrs afcsdkldey lenegklmet
      841 smgfssnapt spvvyqlptk stsyvrtlds vlkkqstisp stsyslkphs vppvsrkaks
      901 qnrqatfsgr tkssyksilp ypvspkqkys hvilgdkvtk nssgiisenq annfvvptld
      961 enifpkqisl rqaqqqqqqq qgsrppglsk sqvklmdled calwegkprt yiteeradvs
     1021 lttlltaqas lktkpihtii rkrappcnnd fcrlgcvcss lalekrqpah crrpdcmfgc
     1081 tclkrkvvlv kggsktkhfq rkaahrdpvf ydtlgeeare eeegireeee qlkekkkrkk
     1141 leyticetep eqpvrhyplw vkvegevdpe pvyiptpsvi epmkplllpq pevlsptvkg
     1201 klltgikspr sytpkpnpvi reedkdpvyl yfesmmtcar vrvyerkked qrqpsssssp
     1261 spsfqqqtsc hsspenhnna kepdseqqpl kqltcdledd sdklqekswk sscnegesss
     1321 tsymhqrspg gptklieiis dcnweedrnk ilsilsqhin snmpqslkvn gksypqakll
     1381 lgqmgalhpa nrlaayitgr lrpsvldlst lstviskvas nakvaasrkp rtllpstsns
     1441 kmasssgtat nrpgknlkaf vpakrpiena aqipvatpqv spntvkragp rlllipvqqg
     1501 sptlrpvsnt qlqghrmvlq pvrspsgmnl frhpngqivq llplhqlrgs ntqpnlqpvm
     1561 frnpgsvmgi rlpapskpse tppsstsssa fsvmnpviqa vgsssavnvi tqapsllssg
     1621 asfvsqagtl tlrisppepq sfasktgset kityssggqp vgtasliplq sgsfallqlp
     1681 gqkpvpssil qhvaslqmkr esqnpdqkde tnsikreqet kkvlqsegea vdpeanvikq
     1741 nsgaatseet lndsledrgd hldeeclpee gcatvkpseh scitgshtdq dykdvneeyg
     1801 arnrksskek vavlevrtis ekasnktvqn lskvqhqklg dvkveqqkgf dnpeenssef
     1861 pvtfkeeskf elsgskvmeq qsnlqpeake kecgdslekd rerwrkhlkg pltrkcvgas
     1921 qeckkeadeq liketktcqe nsdvfqqeqg isdllgksgi tedarvlkte cdswsrisnp
     1981 safsivprra akssrgnghf qghlllpgeq iqpkqekkgg rssadftvld leeddeddne
     2041 ktddsideiv dvvsdyqsee vddveknncv eyieddeehv dietveelse einvahlktt
     2101 aahtqsfkqp scthisadek aaersrkapp iplklkpdyw sdklqkeaea fayyrrthta
     2161 nerrrrgemr dlfeklkitl gllhsskvsk sliltrafse iqgltdqadk ligqknlltr
     2221 krnilirkvs slsgkteevv lkkleyiyak qqaleaqkrk kkmgsdefdi spriskqqeg
     2281 ssassvdlgq mfinnrrgkp lilsrkkdqa tentsplntp htsanlvmtp qgqlltlkgp
     2341 lfsgpvvavs pdllesdlkp qvagsavalp enddlfmmpr ivnvtslate gglvdmggsk
     2401 yphevpdskp sdhlkdtvrn ednsledkgr issrgnrdgr vtlgptqvfl ankdsgypqi
     2461 vdvsnmqkaq eflpkkisgd mrgiqykwke sesrgervks kdssfhklkm kdlkdssiem
     2521 elrkvtsaie eaaldssell tnmededdtd etltsllnei aflnqqlndd svglaelpss
     2581 mdtefpgdar rafiskvppg sratfqvehl gtglkelpdv qgesdsispl llhledddfs
     2641 enekqlaepa sepdvlkivi dseikdslls nkkaidggkn tsglpaepes vsspptlhmk
     2701 tglensnstd tlwrpmpkla plglkvanps sdadgqslkv mpclapiaak vgsvghkmnl
     2761 tgndqegres kvmptlapvv aklgnsgasp ssagk
//
LOCUS       XP_047288251            2795 aa            linear   PRI 05-AUG-2025
DEFINITION  MAX gene-associated protein isoform X14 [Homo sapiens].
ACCESSION   XP_047288251
VERSION     XP_047288251.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432295.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2795
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2795
                     /product="MAX gene-associated protein isoform X14"
                     /calculated_mol_wt=308574
     Region          75..260
                     /region_name="T-box_MGA-like"
                     /note="DNA-binding domain of MAX gene-associated protein
                     and related T-box proteins; cd20195"
                     /db_xref="CDD:410321"
     Site            order(102..103,136,180,183,196..197,237..240,245,248..249,
                     252..258)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410321"
     Region          1041..1082
                     /region_name="MGA_dom"
                     /note="MGA, conserved domain; pfam16059"
                     /db_xref="CDD:464998"
     Region          2155..2219
                     /region_name="bHLHzip_MGA"
                     /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain
                     found in MAX gene-associated protein (MGA) and similar
                     proteins; cd18911"
                     /db_xref="CDD:381481"
     Site            order(2155,2157..2159,2161..2163,2165..2166,2170,
                     2189..2190)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381481"
     Site            order(2169,2172..2173,2175..2176,2179..2181,2191,
                     2194..2195,2198,2200..2202,2204..2205,2207..2208,2211,
                     2214..2215,2218..2219)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381481"
     CDS             1..2795
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /coded_by="XM_047432295.1:143..8530"
                     /db_xref="GeneID:23269"
                     /db_xref="HGNC:HGNC:14010"
                     /db_xref="MIM:616061"
ORIGIN      
        1 meekqqiila nqdggtvaga aptffvilkq pgngktdqgi lvtnqdacal assvsspvks
       61 kgkiclpadc tvggitvtld nnsmwnefyh rstemiltkq grrmfpycry witgldsnlk
      121 yilvmdispv dnhrykwngr wwepsgkaep hvlgrvfihp espstghywm hqpvsfyklk
      181 ltnntldqeg hiilhsmhry lprlhlvpae kaveviqlng pgvhtftfpq teffavtayq
      241 niqitqlkid ynpfakgfrd dglnnkpqrd gkqknssdqe gnnissssgh rvrltegqgs
      301 eiqpgdldpl srghetsgkg lektslnikr dflgfmdtds alsevpqlkq eisecliass
      361 feddsrvasp ldqngsfnvv ikeeplddyd yelgecpegv tvkqeetdee tdvysnsddd
      421 pilekqlkrh nkvdnpeadh lsskwlpssp sgvakakmfk ldtgkmpvvy lepcavtrst
      481 vkiselpdnm lstsrkdkss mlaeleylpt yiensnetaf clgkesengl rkhspdlrvv
      541 qkypllkepq wkypdisdsi sterilddsk dsvgdslsgk edlgrkrttm lkiataakvv
      601 nanqnaspnv pgkrgrprkl klckagrppk ntgkslistk ntpvspgstf pdvkpdledv
      661 dgvlfvsfes kealdihavd gtteessslq asttndsgyr arisqlekel iedlktlrhk
      721 qvihpglqev glklnsvdpt msidlkylgv qlplapatsf pfwnltgtnp aspdagfpfv
      781 srtgktndft kikgwrgkfh sasasrnegg nsesslknrs afcsdkldey lenegklmet
      841 smgfssnapt spvvyqlptk stsyvrtlds vlkkqstisp stsyslkphs vppvsrkaks
      901 qnrqatfsgr tkssyksilp ypvspkqkys hvilgdkvtk nssgiisenq annfvvptld
      961 enifpkqisl rqaqqqqqqq qgsrppglsk sqvklmdled calwegkprt yiteeradvs
     1021 lttlltaqas lktkpihtii rkrappcnnd fcrlgcvcss lalekrqpah crrpdcmfgc
     1081 tclkrkvvlv kggsktkhfq rkaahrdpvf ydtlgeeare eeegireeee qlkekkkrkk
     1141 leyticetep eqpvrhyplw vkvegevdpe pvyiptpsvi epmkplllpq pevlsptvkg
     1201 klltgikspr sytpkpnpvi reedkdpvyl yfesmmtcar vrvyerkked qrqpsssssp
     1261 spsfqqqtsc hsspenhnna kepdseqqpl kqltcdledd sdklqekswk sscnegesss
     1321 tsymhqrspg gptklieiis dcnweedrnk ilsilsqhin snmpqslkvn gksypqakll
     1381 lgqmgalhpa nrlaayitgr lrpsvldlst lstviskvas nakvaasrkp rtllpstsns
     1441 kmasssgtat nrpgknlkaf vpakrpiena aqipvatpqv spntvkragp rlllipvqqg
     1501 sptlrpvsnt qlqghrmvlq pvrspsgmnl frhpngqivq llplhqlrgs ntqpnlqpvm
     1561 frnpgsvmgi rlpapskpse tppsstsssa fsvmnpviqa vgsssavnvi tqapsllssg
     1621 asfvsqagtl tlrisppepq sfasktgset kityssggqp vgtasliplq sgsfallqlp
     1681 gqkpvpssil qhvaslqmkr esqnpdqkde tnsikreqet kkvlqsegea vdpeanvikq
     1741 nsgaatseet lndsledrgd hldeeclpee gcatvkpseh scitgshtdq dykdvneeyg
     1801 arnrksskek vavlevrtis ekasnktvqn lskvqhqklg dvkveqqkgf dnpeenssef
     1861 pvtfkeeskf elsgskvmeq qsnlqpeake kecgdslekd rerwrkhlkg pltrkcvgas
     1921 qeckkeadeq liketktcqe nsdvfqqeqg isdllgksgi tedarvlkte cdswsrisnp
     1981 safsivprra akssrgnghf qghlllpgeq iqpkqekkgg rssadftvld leeddeddne
     2041 ktddsideiv dvvsdyqsee vddveknncv eyieddeehv dietveelse einvahlktt
     2101 aahtqsfkqp scthisadek aaersrkapp iplklkpdyw sdklqkeaea fayyrrthta
     2161 nerrrrgemr dlfeklkitl gllhsskvsk sliltrafse iqgltdqadk ligqknlltr
     2221 krnilirkvs slsgkteevv lkkleyiyak qqaleaqkrk kkmgsdefdi spriskqqeg
     2281 ssassvdlgq mfinnrrgkp lilsrkkdqa tentsplntp htsanlvmtp qgqlltlkgp
     2341 lfsgpvvavs pdllesdlkp qvagsavalp enddlfmmpr ivnvtslate gglvdmggsk
     2401 yphevpdskp sdhlkdtvrn ednsledkgr issrgnrdgr vtlgptqvfl ankdsgypqi
     2461 vdvsnmqkaq eflpkkisgd mrgiqykwke sesrgervks kdssfhklkm kdlkdssiem
     2521 elrkvtsaie eaaldssell tnmededdtd etltsllnei aflnqqlndd svglaelpss
     2581 mdtefpgdar rafiskvppg sratfqvehl gtglkelpdv qgesdsispl llhledddfs
     2641 enekqlaepa sepdvlkivi dseikdslls nkkaidggkn tsglpaepes vsspptlhmk
     2701 tglensnstd tlwrpmpkla plglkvanps sdadgqslkv mpclapiaak vgsvghkmnl
     2761 tgndqegres kvmptlapvv aklgnsgasp ssagk
//
LOCUS       XP_047288252            2795 aa            linear   PRI 05-AUG-2025
DEFINITION  MAX gene-associated protein isoform X14 [Homo sapiens].
ACCESSION   XP_047288252
VERSION     XP_047288252.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432296.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2795
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2795
                     /product="MAX gene-associated protein isoform X14"
                     /calculated_mol_wt=308574
     Region          75..260
                     /region_name="T-box_MGA-like"
                     /note="DNA-binding domain of MAX gene-associated protein
                     and related T-box proteins; cd20195"
                     /db_xref="CDD:410321"
     Site            order(102..103,136,180,183,196..197,237..240,245,248..249,
                     252..258)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410321"
     Region          1041..1082
                     /region_name="MGA_dom"
                     /note="MGA, conserved domain; pfam16059"
                     /db_xref="CDD:464998"
     Region          2155..2219
                     /region_name="bHLHzip_MGA"
                     /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain
                     found in MAX gene-associated protein (MGA) and similar
                     proteins; cd18911"
                     /db_xref="CDD:381481"
     Site            order(2155,2157..2159,2161..2163,2165..2166,2170,
                     2189..2190)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381481"
     Site            order(2169,2172..2173,2175..2176,2179..2181,2191,
                     2194..2195,2198,2200..2202,2204..2205,2207..2208,2211,
                     2214..2215,2218..2219)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381481"
     CDS             1..2795
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /coded_by="XM_047432296.1:165..8552"
                     /db_xref="GeneID:23269"
                     /db_xref="HGNC:HGNC:14010"
                     /db_xref="MIM:616061"
ORIGIN      
        1 meekqqiila nqdggtvaga aptffvilkq pgngktdqgi lvtnqdacal assvsspvks
       61 kgkiclpadc tvggitvtld nnsmwnefyh rstemiltkq grrmfpycry witgldsnlk
      121 yilvmdispv dnhrykwngr wwepsgkaep hvlgrvfihp espstghywm hqpvsfyklk
      181 ltnntldqeg hiilhsmhry lprlhlvpae kaveviqlng pgvhtftfpq teffavtayq
      241 niqitqlkid ynpfakgfrd dglnnkpqrd gkqknssdqe gnnissssgh rvrltegqgs
      301 eiqpgdldpl srghetsgkg lektslnikr dflgfmdtds alsevpqlkq eisecliass
      361 feddsrvasp ldqngsfnvv ikeeplddyd yelgecpegv tvkqeetdee tdvysnsddd
      421 pilekqlkrh nkvdnpeadh lsskwlpssp sgvakakmfk ldtgkmpvvy lepcavtrst
      481 vkiselpdnm lstsrkdkss mlaeleylpt yiensnetaf clgkesengl rkhspdlrvv
      541 qkypllkepq wkypdisdsi sterilddsk dsvgdslsgk edlgrkrttm lkiataakvv
      601 nanqnaspnv pgkrgrprkl klckagrppk ntgkslistk ntpvspgstf pdvkpdledv
      661 dgvlfvsfes kealdihavd gtteessslq asttndsgyr arisqlekel iedlktlrhk
      721 qvihpglqev glklnsvdpt msidlkylgv qlplapatsf pfwnltgtnp aspdagfpfv
      781 srtgktndft kikgwrgkfh sasasrnegg nsesslknrs afcsdkldey lenegklmet
      841 smgfssnapt spvvyqlptk stsyvrtlds vlkkqstisp stsyslkphs vppvsrkaks
      901 qnrqatfsgr tkssyksilp ypvspkqkys hvilgdkvtk nssgiisenq annfvvptld
      961 enifpkqisl rqaqqqqqqq qgsrppglsk sqvklmdled calwegkprt yiteeradvs
     1021 lttlltaqas lktkpihtii rkrappcnnd fcrlgcvcss lalekrqpah crrpdcmfgc
     1081 tclkrkvvlv kggsktkhfq rkaahrdpvf ydtlgeeare eeegireeee qlkekkkrkk
     1141 leyticetep eqpvrhyplw vkvegevdpe pvyiptpsvi epmkplllpq pevlsptvkg
     1201 klltgikspr sytpkpnpvi reedkdpvyl yfesmmtcar vrvyerkked qrqpsssssp
     1261 spsfqqqtsc hsspenhnna kepdseqqpl kqltcdledd sdklqekswk sscnegesss
     1321 tsymhqrspg gptklieiis dcnweedrnk ilsilsqhin snmpqslkvn gksypqakll
     1381 lgqmgalhpa nrlaayitgr lrpsvldlst lstviskvas nakvaasrkp rtllpstsns
     1441 kmasssgtat nrpgknlkaf vpakrpiena aqipvatpqv spntvkragp rlllipvqqg
     1501 sptlrpvsnt qlqghrmvlq pvrspsgmnl frhpngqivq llplhqlrgs ntqpnlqpvm
     1561 frnpgsvmgi rlpapskpse tppsstsssa fsvmnpviqa vgsssavnvi tqapsllssg
     1621 asfvsqagtl tlrisppepq sfasktgset kityssggqp vgtasliplq sgsfallqlp
     1681 gqkpvpssil qhvaslqmkr esqnpdqkde tnsikreqet kkvlqsegea vdpeanvikq
     1741 nsgaatseet lndsledrgd hldeeclpee gcatvkpseh scitgshtdq dykdvneeyg
     1801 arnrksskek vavlevrtis ekasnktvqn lskvqhqklg dvkveqqkgf dnpeenssef
     1861 pvtfkeeskf elsgskvmeq qsnlqpeake kecgdslekd rerwrkhlkg pltrkcvgas
     1921 qeckkeadeq liketktcqe nsdvfqqeqg isdllgksgi tedarvlkte cdswsrisnp
     1981 safsivprra akssrgnghf qghlllpgeq iqpkqekkgg rssadftvld leeddeddne
     2041 ktddsideiv dvvsdyqsee vddveknncv eyieddeehv dietveelse einvahlktt
     2101 aahtqsfkqp scthisadek aaersrkapp iplklkpdyw sdklqkeaea fayyrrthta
     2161 nerrrrgemr dlfeklkitl gllhsskvsk sliltrafse iqgltdqadk ligqknlltr
     2221 krnilirkvs slsgkteevv lkkleyiyak qqaleaqkrk kkmgsdefdi spriskqqeg
     2281 ssassvdlgq mfinnrrgkp lilsrkkdqa tentsplntp htsanlvmtp qgqlltlkgp
     2341 lfsgpvvavs pdllesdlkp qvagsavalp enddlfmmpr ivnvtslate gglvdmggsk
     2401 yphevpdskp sdhlkdtvrn ednsledkgr issrgnrdgr vtlgptqvfl ankdsgypqi
     2461 vdvsnmqkaq eflpkkisgd mrgiqykwke sesrgervks kdssfhklkm kdlkdssiem
     2521 elrkvtsaie eaaldssell tnmededdtd etltsllnei aflnqqlndd svglaelpss
     2581 mdtefpgdar rafiskvppg sratfqvehl gtglkelpdv qgesdsispl llhledddfs
     2641 enekqlaepa sepdvlkivi dseikdslls nkkaidggkn tsglpaepes vsspptlhmk
     2701 tglensnstd tlwrpmpkla plglkvanps sdadgqslkv mpclapiaak vgsvghkmnl
     2761 tgndqegres kvmptlapvv aklgnsgasp ssagk
//
LOCUS       XP_047288253            2746 aa            linear   PRI 05-AUG-2025
DEFINITION  MAX gene-associated protein isoform X15 [Homo sapiens].
ACCESSION   XP_047288253
VERSION     XP_047288253.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432297.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2746
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2746
                     /product="MAX gene-associated protein isoform X15"
                     /calculated_mol_wt=303371
     Region          75..260
                     /region_name="T-box_MGA-like"
                     /note="DNA-binding domain of MAX gene-associated protein
                     and related T-box proteins; cd20195"
                     /db_xref="CDD:410321"
     Site            order(102..103,136,180,183,196..197,237..240,245,248..249,
                     252..258)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410321"
     Region          1041..1082
                     /region_name="MGA_dom"
                     /note="MGA, conserved domain; pfam16059"
                     /db_xref="CDD:464998"
     Region          2106..2170
                     /region_name="bHLHzip_MGA"
                     /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain
                     found in MAX gene-associated protein (MGA) and similar
                     proteins; cd18911"
                     /db_xref="CDD:381481"
     Site            order(2106,2108..2110,2112..2114,2116..2117,2121,
                     2140..2141)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381481"
     Site            order(2120,2123..2124,2126..2127,2130..2132,2142,
                     2145..2146,2149,2151..2153,2155..2156,2158..2159,2162,
                     2165..2166,2169..2170)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381481"
     CDS             1..2746
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /coded_by="XM_047432297.1:189..8429"
                     /db_xref="GeneID:23269"
                     /db_xref="HGNC:HGNC:14010"
                     /db_xref="MIM:616061"
ORIGIN      
        1 meekqqiila nqdggtvaga aptffvilkq pgngktdqgi lvtnqdacal assvsspvks
       61 kgkiclpadc tvggitvtld nnsmwnefyh rstemiltkq grrmfpycry witgldsnlk
      121 yilvmdispv dnhrykwngr wwepsgkaep hvlgrvfihp espstghywm hqpvsfyklk
      181 ltnntldqeg hiilhsmhry lprlhlvpae kaveviqlng pgvhtftfpq teffavtayq
      241 niqitqlkid ynpfakgfrd dglnnkpqrd gkqknssdqe gnnissssgh rvrltegqgs
      301 eiqpgdldpl srghetsgkg lektslnikr dflgfmdtds alsevpqlkq eisecliass
      361 feddsrvasp ldqngsfnvv ikeeplddyd yelgecpegv tvkqeetdee tdvysnsddd
      421 pilekqlkrh nkvdnpeadh lsskwlpssp sgvakakmfk ldtgkmpvvy lepcavtrst
      481 vkiselpdnm lstsrkdkss mlaeleylpt yiensnetaf clgkesengl rkhspdlrvv
      541 qkypllkepq wkypdisdsi sterilddsk dsvgdslsgk edlgrkrttm lkiataakvv
      601 nanqnaspnv pgkrgrprkl klckagrppk ntgkslistk ntpvspgstf pdvkpdledv
      661 dgvlfvsfes kealdihavd gtteessslq asttndsgyr arisqlekel iedlktlrhk
      721 qvihpglqev glklnsvdpt msidlkylgv qlplapatsf pfwnltgtnp aspdagfpfv
      781 srtgktndft kikgwrgkfh sasasrnegg nsesslknrs afcsdkldey lenegklmet
      841 smgfssnapt spvvyqlptk stsyvrtlds vlkkqstisp stsyslkphs vppvsrkaks
      901 qnrqatfsgr tkssyksilp ypvspkqkys hvilgdkvtk nssgiisenq annfvvptld
      961 enifpkqisl rqaqqqqqqq qgsrppglsk sqvklmdled calwegkprt yiteeradvs
     1021 lttlltaqas lktkpihtii rkrappcnnd fcrlgcvcss lalekrqpah crrpdcmfgc
     1081 tclkrkvvlv kggsktkhfq rkaahrdpvf ydtlgeeare eeegireeee qlkekkkrkk
     1141 leyticetep eqpvrhyplw vkvegevdpe pvyiptpsvi epmkplllpq pevlsptvkg
     1201 klltgikspr sytpkpnpvi reedkdpvyl yfesmmtcar vrvyerkked qrqpsssssp
     1261 spsfqqqtsc hsspenhnna kepdseqqpl kqltcdledd sdklqekswk sscnegesss
     1321 tsymhqrspg gptklieiis dcnweedrnk ilsilsqhin snmpqslkva snakvaasrk
     1381 prtllpstsn skmasssgta tnrpgknlka fvpakrpien aaqipvatpq vspntvkrag
     1441 prlllipvqq gsptlrpvsn tqlqghrmvl qpvrspsgmn lfrhpngqiv qllplhqlrg
     1501 sntqpnlqpv mfrnpgsvmg irlpapskps etppsstsss afsvmnpviq avgsssavnv
     1561 itqapsllss gasfvsqagt ltlrisppep qsfasktgse tkityssggq pvgtaslipl
     1621 qsgsfallql pgqkpvpssi lqhvaslqmk resqnpdqkd etnsikreqe tkkvlqsege
     1681 avdpeanvik qnsgaatsee tlndsledrg dhldeeclpe egcatvkpse hscitgshtd
     1741 qdykdvneey garnrksske kvavlevrti sekasnktvq nlskvqhqkl gdvkveqqkg
     1801 fdnpeensse fpvtfkeesk felsgskvme qqsnlqpeak ekecgdslek drerwrkhlk
     1861 gpltrkcvga sqeckkeade qliketktcq ensdvfqqeq gisdllgksg itedarvlkt
     1921 ecdswsrisn psafsivprr aakssrgngh fqghlllpge qiqpkqekkg grssadftvl
     1981 dleeddeddn ektddsidei vdvvsdyqse evddveknnc veyieddeeh vdietveels
     2041 eeinvahlkt taahtqsfkq pscthisade kaaersrkap piplklkpdy wsdklqkeae
     2101 afayyrrtht anerrrrgem rdlfeklkit lgllhsskvs ksliltrafs eiqgltdqad
     2161 kligqknllt rkrnilirkv sslsgkteev vlkkleyiya kqqaleaqkr kkkmgsdefd
     2221 ispriskqqe gssassvdlg qmfinnrrgk plilsrkkdq atentsplnt phtsanlvmt
     2281 pqgqlltlkg plfsgpvvav spdllesdlk pqvagsaval penddlfmmp rivnvtslat
     2341 egglvdmggs kyphevpdsk psdhlkdtvr nednsledkg rissrgnrdg rvtlgptqvf
     2401 lankdsgypq ivdvsnmqka qeflpkkisg dmrgiqykwk esesrgervk skdssfhklk
     2461 mkdlkdssie melrkvtsai eeaaldssel ltnmededdt detltsllne iaflnqqlnd
     2521 dsvglaelps smdtefpgda rrafiskvpp gsratfqveh lgtglkelpd vqgesdsisp
     2581 lllhledddf senekqlaep asepdvlkiv idseikdsll snkkaidggk ntsglpaepe
     2641 svsspptlhm ktglensnst dtlwrpmpkl aplglkvanp ssdadgqslk vmpclapiaa
     2701 kvgsvghkmn ltgndqegre skvmptlapv vaklgnsgas pssagk
//
LOCUS       XP_047288254            2746 aa            linear   PRI 05-AUG-2025
DEFINITION  MAX gene-associated protein isoform X15 [Homo sapiens].
ACCESSION   XP_047288254
VERSION     XP_047288254.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432298.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2746
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2746
                     /product="MAX gene-associated protein isoform X15"
                     /calculated_mol_wt=303371
     Region          75..260
                     /region_name="T-box_MGA-like"
                     /note="DNA-binding domain of MAX gene-associated protein
                     and related T-box proteins; cd20195"
                     /db_xref="CDD:410321"
     Site            order(102..103,136,180,183,196..197,237..240,245,248..249,
                     252..258)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410321"
     Region          1041..1082
                     /region_name="MGA_dom"
                     /note="MGA, conserved domain; pfam16059"
                     /db_xref="CDD:464998"
     Region          2106..2170
                     /region_name="bHLHzip_MGA"
                     /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain
                     found in MAX gene-associated protein (MGA) and similar
                     proteins; cd18911"
                     /db_xref="CDD:381481"
     Site            order(2106,2108..2110,2112..2114,2116..2117,2121,
                     2140..2141)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381481"
     Site            order(2120,2123..2124,2126..2127,2130..2132,2142,
                     2145..2146,2149,2151..2153,2155..2156,2158..2159,2162,
                     2165..2166,2169..2170)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381481"
     CDS             1..2746
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /coded_by="XM_047432298.1:143..8383"
                     /db_xref="GeneID:23269"
                     /db_xref="HGNC:HGNC:14010"
                     /db_xref="MIM:616061"
ORIGIN      
        1 meekqqiila nqdggtvaga aptffvilkq pgngktdqgi lvtnqdacal assvsspvks
       61 kgkiclpadc tvggitvtld nnsmwnefyh rstemiltkq grrmfpycry witgldsnlk
      121 yilvmdispv dnhrykwngr wwepsgkaep hvlgrvfihp espstghywm hqpvsfyklk
      181 ltnntldqeg hiilhsmhry lprlhlvpae kaveviqlng pgvhtftfpq teffavtayq
      241 niqitqlkid ynpfakgfrd dglnnkpqrd gkqknssdqe gnnissssgh rvrltegqgs
      301 eiqpgdldpl srghetsgkg lektslnikr dflgfmdtds alsevpqlkq eisecliass
      361 feddsrvasp ldqngsfnvv ikeeplddyd yelgecpegv tvkqeetdee tdvysnsddd
      421 pilekqlkrh nkvdnpeadh lsskwlpssp sgvakakmfk ldtgkmpvvy lepcavtrst
      481 vkiselpdnm lstsrkdkss mlaeleylpt yiensnetaf clgkesengl rkhspdlrvv
      541 qkypllkepq wkypdisdsi sterilddsk dsvgdslsgk edlgrkrttm lkiataakvv
      601 nanqnaspnv pgkrgrprkl klckagrppk ntgkslistk ntpvspgstf pdvkpdledv
      661 dgvlfvsfes kealdihavd gtteessslq asttndsgyr arisqlekel iedlktlrhk
      721 qvihpglqev glklnsvdpt msidlkylgv qlplapatsf pfwnltgtnp aspdagfpfv
      781 srtgktndft kikgwrgkfh sasasrnegg nsesslknrs afcsdkldey lenegklmet
      841 smgfssnapt spvvyqlptk stsyvrtlds vlkkqstisp stsyslkphs vppvsrkaks
      901 qnrqatfsgr tkssyksilp ypvspkqkys hvilgdkvtk nssgiisenq annfvvptld
      961 enifpkqisl rqaqqqqqqq qgsrppglsk sqvklmdled calwegkprt yiteeradvs
     1021 lttlltaqas lktkpihtii rkrappcnnd fcrlgcvcss lalekrqpah crrpdcmfgc
     1081 tclkrkvvlv kggsktkhfq rkaahrdpvf ydtlgeeare eeegireeee qlkekkkrkk
     1141 leyticetep eqpvrhyplw vkvegevdpe pvyiptpsvi epmkplllpq pevlsptvkg
     1201 klltgikspr sytpkpnpvi reedkdpvyl yfesmmtcar vrvyerkked qrqpsssssp
     1261 spsfqqqtsc hsspenhnna kepdseqqpl kqltcdledd sdklqekswk sscnegesss
     1321 tsymhqrspg gptklieiis dcnweedrnk ilsilsqhin snmpqslkva snakvaasrk
     1381 prtllpstsn skmasssgta tnrpgknlka fvpakrpien aaqipvatpq vspntvkrag
     1441 prlllipvqq gsptlrpvsn tqlqghrmvl qpvrspsgmn lfrhpngqiv qllplhqlrg
     1501 sntqpnlqpv mfrnpgsvmg irlpapskps etppsstsss afsvmnpviq avgsssavnv
     1561 itqapsllss gasfvsqagt ltlrisppep qsfasktgse tkityssggq pvgtaslipl
     1621 qsgsfallql pgqkpvpssi lqhvaslqmk resqnpdqkd etnsikreqe tkkvlqsege
     1681 avdpeanvik qnsgaatsee tlndsledrg dhldeeclpe egcatvkpse hscitgshtd
     1741 qdykdvneey garnrksske kvavlevrti sekasnktvq nlskvqhqkl gdvkveqqkg
     1801 fdnpeensse fpvtfkeesk felsgskvme qqsnlqpeak ekecgdslek drerwrkhlk
     1861 gpltrkcvga sqeckkeade qliketktcq ensdvfqqeq gisdllgksg itedarvlkt
     1921 ecdswsrisn psafsivprr aakssrgngh fqghlllpge qiqpkqekkg grssadftvl
     1981 dleeddeddn ektddsidei vdvvsdyqse evddveknnc veyieddeeh vdietveels
     2041 eeinvahlkt taahtqsfkq pscthisade kaaersrkap piplklkpdy wsdklqkeae
     2101 afayyrrtht anerrrrgem rdlfeklkit lgllhsskvs ksliltrafs eiqgltdqad
     2161 kligqknllt rkrnilirkv sslsgkteev vlkkleyiya kqqaleaqkr kkkmgsdefd
     2221 ispriskqqe gssassvdlg qmfinnrrgk plilsrkkdq atentsplnt phtsanlvmt
     2281 pqgqlltlkg plfsgpvvav spdllesdlk pqvagsaval penddlfmmp rivnvtslat
     2341 egglvdmggs kyphevpdsk psdhlkdtvr nednsledkg rissrgnrdg rvtlgptqvf
     2401 lankdsgypq ivdvsnmqka qeflpkkisg dmrgiqykwk esesrgervk skdssfhklk
     2461 mkdlkdssie melrkvtsai eeaaldssel ltnmededdt detltsllne iaflnqqlnd
     2521 dsvglaelps smdtefpgda rrafiskvpp gsratfqveh lgtglkelpd vqgesdsisp
     2581 lllhledddf senekqlaep asepdvlkiv idseikdsll snkkaidggk ntsglpaepe
     2641 svsspptlhm ktglensnst dtlwrpmpkl aplglkvanp ssdadgqslk vmpclapiaa
     2701 kvgsvghkmn ltgndqegre skvmptlapv vaklgnsgas pssagk
//
LOCUS       XP_016877518            2658 aa            linear   PRI 05-AUG-2025
DEFINITION  MAX gene-associated protein isoform X16 [Homo sapiens].
ACCESSION   XP_016877518
VERSION     XP_016877518.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022029.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2658
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2658
                     /product="MAX gene-associated protein isoform X16"
                     /calculated_mol_wt=290227
     Region          584..625
                     /region_name="MGA_dom"
                     /note="MGA, conserved domain; pfam16059"
                     /db_xref="CDD:464998"
     Region          <1062..1363
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          1253..>1575
                     /region_name="Atrophin-1"
                     /note="Atrophin-1 family; pfam03154"
                     /db_xref="CDD:460830"
     Region          2018..2082
                     /region_name="bHLHzip_MGA"
                     /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain
                     found in MAX gene-associated protein (MGA) and similar
                     proteins; cd18911"
                     /db_xref="CDD:381481"
     Site            order(2018,2020..2022,2024..2026,2028..2029,2033,
                     2052..2053)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381481"
     Site            order(2032,2035..2036,2038..2039,2042..2044,2054,
                     2057..2058,2061,2063..2065,2067..2068,2070..2071,2074,
                     2077..2078,2081..2082)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381481"
     CDS             1..2658
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /coded_by="XM_017022029.3:674..8650"
                     /db_xref="GeneID:23269"
                     /db_xref="HGNC:HGNC:14010"
                     /db_xref="MIM:616061"
ORIGIN      
        1 mfkldtgkmp vvylepcavt rstvkiselp dnmlstsrkd kssmlaeley lptyiensne
       61 tafclgkese nglrkhspdl rvvqkypllk epqwkypdis dsisterild dskdsvgdsl
      121 sgkedlgrkr ttmlkiataa kvvnanqnas pnvpgkrgrp rklklckagr ppkntgksli
      181 stkntpvspg stfpdvkpdl edvdgvlfvs feskealdih avdgtteess slqasttnds
      241 gyrarisqle keliedlktl rhkqvihpgl qevglklnsv dptmsidlky lgvqlplapa
      301 tsfpfwnltg tnpaspdagf pfvsrtgktn dftkikgwrg kfhsasasrn eggnsesslk
      361 nrsafcsdkl deylenegkl metsmgfssn aptspvvyql ptkstsyvrt ldsvlkkqst
      421 ispstsyslk phsvppvsrk aksqnrqatf sgrtkssyks ilpypvspkq kyshvilgdk
      481 vtknssgiis enqannfvvp tldenifpkq islrqaqqqq qqqqgsrppg lsksqvklmd
      541 ledcalwegk prtyiteera dvslttllta qaslktkpih tiirkrappc nndfcrlgcv
      601 csslalekrq pahcrrpdcm fgctclkrkv vlvkggsktk hfqrkaahrd pvfydtlgee
      661 areeeegire eeeqlkekkk rkkleytice tepeqpvrhy plwvkvegev dpepvyiptp
      721 sviepmkpll lpqpevlspt vkgklltgik sprsytpkpn pvireedkdp vylyfesmmt
      781 carvrvyerk kedqrqpsss sspspsfqqq tschsspenh nnakepdseq qplkqltcdl
      841 eddsdklqek swksscnege ssstsymhqr spggptklie iisdcnweed rnkilsilsq
      901 hinsnmpqsl kvgsfiiela sqrksrgekn ppvyssrvki smpscqdqdd maeksgsetp
      961 dgplspgkme dispvqtdal dsvrerlhgg kglpfyagls pagklvaykr kpssstsgli
     1021 qvngksypqa klllgqmgal hpanrlaayi tgrlrpsvld lstlstvisk vasnakvaas
     1081 rkprtllpst snskmasssg tatnrpgknl kafvpakrpi aarpspggvf tqfvmskvga
     1141 lqqkipgvst pqtlagtqkf sirpspvmvv tpvvssepvq vcspvtaavt tttpqvflen
     1201 ttavtpmtai sdvetketty ssgatttgvv evsetntsts vtstqstatv nltkttgitt
     1261 pvasvafpks lvaspstitl pvastastsl vvvtaaasss mvttptsslg svpiilsgin
     1321 gsppvsqrpe naaqipvatp qvspntvkra gprlllipvq qgsptlrpvs ntqlqghrmv
     1381 lqpvrspsgm nlfrhpngqi vqllplhqlr gsntqpnlqp vmfrnpgsvm girlpapskp
     1441 setppsstss safsvmnpvi qavgsssavn vitqapslls sgasfvsqag tltlrisppe
     1501 pqsfasktgs etkityssgg qpvgtaslip lqsgsfallq lpgqkpvpss ilqhvaslqm
     1561 kresqnpdqk detnsikreq etkkvlqseg eavdpeanvi kqnsgaatse etlndsledr
     1621 gdhldeeclp eegcatvkps ehscitgsht dqdykdvnee ygarnrkssk ekvavlevrt
     1681 isekasnktv qnlskvqhqk lgdvkveqqk gfdnpeenss efpvtfkees kfelsgskvm
     1741 eqqsnlqpea kekecgdsle kdrerwrkhl kgpltrkcvg asqeckkead eqliketktc
     1801 qensdvfqqe qgisdllgks gitedarvlk tecdswsris npsafsivpr raakssrgng
     1861 hfqghlllpg eqiqpkqekk ggrssadftv ldleeddedd nektddside ivdvvsdyqs
     1921 eevddvekvn ncveyiedde ehvdietvee lseeinvahl kttaahtqsf kqpscthisa
     1981 dekaaersrk appiplklkp dywsdklqke aeafayyrrt htanerrrrg emrdlfeklk
     2041 itlgllhssk vsksliltra fseiqgltdq adkligqknl ltrkrnilir kvsslsgkte
     2101 evvlkkleyi yakqqaleaq krkkkmgsde fdispriskq qegssassvd lgqmfinnrr
     2161 gkplilsrkk dqatentspl ntphtsanlv mtpqgqlltl kgplfsgpvv avspdllesd
     2221 lkpqvagsav alpenddlfm mprivnvtsl ategglvdmg gskyphevpd skpsdhlkdt
     2281 vrnednsled kgrissrgnr dgrvtlgptq vflankdsgy pqivdvsnmq kaqeflpkki
     2341 sgdmrgiqyk wkesesrger vkskdssfhk lkmkdlkdss iemelrkvts aieeaaldss
     2401 elltnmeded dtdetltsll neiaflnqql nddsvglael pssmdtefpg darrafiskv
     2461 ppgsratfqv ehlgtglkel pdvqgesdsi splllhledd dfsenekqla epasepdvlk
     2521 ividseikds llsnkkaidg gkntsglpae pesvsspptl hmktglensn stdtlwrpmp
     2581 klaplglkva npssdadgqs lkvmpclapi aakvgsvghk mnltgndqeg reskvmptla
     2641 pvvaklgnsg aspssagk
//
LOCUS       XP_006720508            2658 aa            linear   PRI 05-AUG-2025
DEFINITION  MAX gene-associated protein isoform X16 [Homo sapiens].
ACCESSION   XP_006720508
VERSION     XP_006720508.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720445.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2658
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2658
                     /product="MAX gene-associated protein isoform X16"
                     /calculated_mol_wt=290227
     Region          584..625
                     /region_name="MGA_dom"
                     /note="MGA, conserved domain; pfam16059"
                     /db_xref="CDD:464998"
     Region          <1062..1363
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          1253..>1575
                     /region_name="Atrophin-1"
                     /note="Atrophin-1 family; pfam03154"
                     /db_xref="CDD:460830"
     Region          2018..2082
                     /region_name="bHLHzip_MGA"
                     /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain
                     found in MAX gene-associated protein (MGA) and similar
                     proteins; cd18911"
                     /db_xref="CDD:381481"
     Site            order(2018,2020..2022,2024..2026,2028..2029,2033,
                     2052..2053)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381481"
     Site            order(2032,2035..2036,2038..2039,2042..2044,2054,
                     2057..2058,2061,2063..2065,2067..2068,2070..2071,2074,
                     2077..2078,2081..2082)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381481"
     CDS             1..2658
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /coded_by="XM_006720445.5:383..8359"
                     /db_xref="GeneID:23269"
                     /db_xref="HGNC:HGNC:14010"
                     /db_xref="MIM:616061"
ORIGIN      
        1 mfkldtgkmp vvylepcavt rstvkiselp dnmlstsrkd kssmlaeley lptyiensne
       61 tafclgkese nglrkhspdl rvvqkypllk epqwkypdis dsisterild dskdsvgdsl
      121 sgkedlgrkr ttmlkiataa kvvnanqnas pnvpgkrgrp rklklckagr ppkntgksli
      181 stkntpvspg stfpdvkpdl edvdgvlfvs feskealdih avdgtteess slqasttnds
      241 gyrarisqle keliedlktl rhkqvihpgl qevglklnsv dptmsidlky lgvqlplapa
      301 tsfpfwnltg tnpaspdagf pfvsrtgktn dftkikgwrg kfhsasasrn eggnsesslk
      361 nrsafcsdkl deylenegkl metsmgfssn aptspvvyql ptkstsyvrt ldsvlkkqst
      421 ispstsyslk phsvppvsrk aksqnrqatf sgrtkssyks ilpypvspkq kyshvilgdk
      481 vtknssgiis enqannfvvp tldenifpkq islrqaqqqq qqqqgsrppg lsksqvklmd
      541 ledcalwegk prtyiteera dvslttllta qaslktkpih tiirkrappc nndfcrlgcv
      601 csslalekrq pahcrrpdcm fgctclkrkv vlvkggsktk hfqrkaahrd pvfydtlgee
      661 areeeegire eeeqlkekkk rkkleytice tepeqpvrhy plwvkvegev dpepvyiptp
      721 sviepmkpll lpqpevlspt vkgklltgik sprsytpkpn pvireedkdp vylyfesmmt
      781 carvrvyerk kedqrqpsss sspspsfqqq tschsspenh nnakepdseq qplkqltcdl
      841 eddsdklqek swksscnege ssstsymhqr spggptklie iisdcnweed rnkilsilsq
      901 hinsnmpqsl kvgsfiiela sqrksrgekn ppvyssrvki smpscqdqdd maeksgsetp
      961 dgplspgkme dispvqtdal dsvrerlhgg kglpfyagls pagklvaykr kpssstsgli
     1021 qvngksypqa klllgqmgal hpanrlaayi tgrlrpsvld lstlstvisk vasnakvaas
     1081 rkprtllpst snskmasssg tatnrpgknl kafvpakrpi aarpspggvf tqfvmskvga
     1141 lqqkipgvst pqtlagtqkf sirpspvmvv tpvvssepvq vcspvtaavt tttpqvflen
     1201 ttavtpmtai sdvetketty ssgatttgvv evsetntsts vtstqstatv nltkttgitt
     1261 pvasvafpks lvaspstitl pvastastsl vvvtaaasss mvttptsslg svpiilsgin
     1321 gsppvsqrpe naaqipvatp qvspntvkra gprlllipvq qgsptlrpvs ntqlqghrmv
     1381 lqpvrspsgm nlfrhpngqi vqllplhqlr gsntqpnlqp vmfrnpgsvm girlpapskp
     1441 setppsstss safsvmnpvi qavgsssavn vitqapslls sgasfvsqag tltlrisppe
     1501 pqsfasktgs etkityssgg qpvgtaslip lqsgsfallq lpgqkpvpss ilqhvaslqm
     1561 kresqnpdqk detnsikreq etkkvlqseg eavdpeanvi kqnsgaatse etlndsledr
     1621 gdhldeeclp eegcatvkps ehscitgsht dqdykdvnee ygarnrkssk ekvavlevrt
     1681 isekasnktv qnlskvqhqk lgdvkveqqk gfdnpeenss efpvtfkees kfelsgskvm
     1741 eqqsnlqpea kekecgdsle kdrerwrkhl kgpltrkcvg asqeckkead eqliketktc
     1801 qensdvfqqe qgisdllgks gitedarvlk tecdswsris npsafsivpr raakssrgng
     1861 hfqghlllpg eqiqpkqekk ggrssadftv ldleeddedd nektddside ivdvvsdyqs
     1921 eevddvekvn ncveyiedde ehvdietvee lseeinvahl kttaahtqsf kqpscthisa
     1981 dekaaersrk appiplklkp dywsdklqke aeafayyrrt htanerrrrg emrdlfeklk
     2041 itlgllhssk vsksliltra fseiqgltdq adkligqknl ltrkrnilir kvsslsgkte
     2101 evvlkkleyi yakqqaleaq krkkkmgsde fdispriskq qegssassvd lgqmfinnrr
     2161 gkplilsrkk dqatentspl ntphtsanlv mtpqgqlltl kgplfsgpvv avspdllesd
     2221 lkpqvagsav alpenddlfm mprivnvtsl ategglvdmg gskyphevpd skpsdhlkdt
     2281 vrnednsled kgrissrgnr dgrvtlgptq vflankdsgy pqivdvsnmq kaqeflpkki
     2341 sgdmrgiqyk wkesesrger vkskdssfhk lkmkdlkdss iemelrkvts aieeaaldss
     2401 elltnmeded dtdetltsll neiaflnqql nddsvglael pssmdtefpg darrafiskv
     2461 ppgsratfqv ehlgtglkel pdvqgesdsi splllhledd dfsenekqla epasepdvlk
     2521 ividseikds llsnkkaidg gkntsglpae pesvsspptl hmktglensn stdtlwrpmp
     2581 klaplglkva npssdadgqs lkvmpclapi aakvgsvghk mnltgndqeg reskvmptla
     2641 pvvaklgnsg aspssagk
//
LOCUS       XP_047288255            2657 aa            linear   PRI 05-AUG-2025
DEFINITION  MAX gene-associated protein isoform X17 [Homo sapiens].
ACCESSION   XP_047288255
VERSION     XP_047288255.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432299.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2657
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2657
                     /product="MAX gene-associated protein isoform X17"
                     /calculated_mol_wt=290128
     Region          584..625
                     /region_name="MGA_dom"
                     /note="MGA, conserved domain; pfam16059"
                     /db_xref="CDD:464998"
     Region          <1062..1363
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          1253..>1575
                     /region_name="Atrophin-1"
                     /note="Atrophin-1 family; pfam03154"
                     /db_xref="CDD:460830"
     Region          2017..2081
                     /region_name="bHLHzip_MGA"
                     /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain
                     found in MAX gene-associated protein (MGA) and similar
                     proteins; cd18911"
                     /db_xref="CDD:381481"
     Site            order(2017,2019..2021,2023..2025,2027..2028,2032,
                     2051..2052)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381481"
     Site            order(2031,2034..2035,2037..2038,2041..2043,2053,
                     2056..2057,2060,2062..2064,2066..2067,2069..2070,2073,
                     2076..2077,2080..2081)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381481"
     CDS             1..2657
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /coded_by="XM_047432299.1:383..8356"
                     /db_xref="GeneID:23269"
                     /db_xref="HGNC:HGNC:14010"
                     /db_xref="MIM:616061"
ORIGIN      
        1 mfkldtgkmp vvylepcavt rstvkiselp dnmlstsrkd kssmlaeley lptyiensne
       61 tafclgkese nglrkhspdl rvvqkypllk epqwkypdis dsisterild dskdsvgdsl
      121 sgkedlgrkr ttmlkiataa kvvnanqnas pnvpgkrgrp rklklckagr ppkntgksli
      181 stkntpvspg stfpdvkpdl edvdgvlfvs feskealdih avdgtteess slqasttnds
      241 gyrarisqle keliedlktl rhkqvihpgl qevglklnsv dptmsidlky lgvqlplapa
      301 tsfpfwnltg tnpaspdagf pfvsrtgktn dftkikgwrg kfhsasasrn eggnsesslk
      361 nrsafcsdkl deylenegkl metsmgfssn aptspvvyql ptkstsyvrt ldsvlkkqst
      421 ispstsyslk phsvppvsrk aksqnrqatf sgrtkssyks ilpypvspkq kyshvilgdk
      481 vtknssgiis enqannfvvp tldenifpkq islrqaqqqq qqqqgsrppg lsksqvklmd
      541 ledcalwegk prtyiteera dvslttllta qaslktkpih tiirkrappc nndfcrlgcv
      601 csslalekrq pahcrrpdcm fgctclkrkv vlvkggsktk hfqrkaahrd pvfydtlgee
      661 areeeegire eeeqlkekkk rkkleytice tepeqpvrhy plwvkvegev dpepvyiptp
      721 sviepmkpll lpqpevlspt vkgklltgik sprsytpkpn pvireedkdp vylyfesmmt
      781 carvrvyerk kedqrqpsss sspspsfqqq tschsspenh nnakepdseq qplkqltcdl
      841 eddsdklqek swksscnege ssstsymhqr spggptklie iisdcnweed rnkilsilsq
      901 hinsnmpqsl kvgsfiiela sqrksrgekn ppvyssrvki smpscqdqdd maeksgsetp
      961 dgplspgkme dispvqtdal dsvrerlhgg kglpfyagls pagklvaykr kpssstsgli
     1021 qvngksypqa klllgqmgal hpanrlaayi tgrlrpsvld lstlstvisk vasnakvaas
     1081 rkprtllpst snskmasssg tatnrpgknl kafvpakrpi aarpspggvf tqfvmskvga
     1141 lqqkipgvst pqtlagtqkf sirpspvmvv tpvvssepvq vcspvtaavt tttpqvflen
     1201 ttavtpmtai sdvetketty ssgatttgvv evsetntsts vtstqstatv nltkttgitt
     1261 pvasvafpks lvaspstitl pvastastsl vvvtaaasss mvttptsslg svpiilsgin
     1321 gsppvsqrpe naaqipvatp qvspntvkra gprlllipvq qgsptlrpvs ntqlqghrmv
     1381 lqpvrspsgm nlfrhpngqi vqllplhqlr gsntqpnlqp vmfrnpgsvm girlpapskp
     1441 setppsstss safsvmnpvi qavgsssavn vitqapslls sgasfvsqag tltlrisppe
     1501 pqsfasktgs etkityssgg qpvgtaslip lqsgsfallq lpgqkpvpss ilqhvaslqm
     1561 kresqnpdqk detnsikreq etkkvlqseg eavdpeanvi kqnsgaatse etlndsledr
     1621 gdhldeeclp eegcatvkps ehscitgsht dqdykdvnee ygarnrkssk ekvavlevrt
     1681 isekasnktv qnlskvqhqk lgdvkveqqk gfdnpeenss efpvtfkees kfelsgskvm
     1741 eqqsnlqpea kekecgdsle kdrerwrkhl kgpltrkcvg asqeckkead eqliketktc
     1801 qensdvfqqe qgisdllgks gitedarvlk tecdswsris npsafsivpr raakssrgng
     1861 hfqghlllpg eqiqpkqekk ggrssadftv ldleeddedd nektddside ivdvvsdyqs
     1921 eevddveknn cveyieddee hvdietveel seeinvahlk ttaahtqsfk qpscthisad
     1981 ekaaersrka ppiplklkpd ywsdklqkea eafayyrrth tanerrrrge mrdlfeklki
     2041 tlgllhsskv sksliltraf seiqgltdqa dkligqknll trkrnilirk vsslsgktee
     2101 vvlkkleyiy akqqaleaqk rkkkmgsdef dispriskqq egssassvdl gqmfinnrrg
     2161 kplilsrkkd qatentspln tphtsanlvm tpqgqlltlk gplfsgpvva vspdllesdl
     2221 kpqvagsava lpenddlfmm privnvtsla tegglvdmgg skyphevpds kpsdhlkdtv
     2281 rnednsledk grissrgnrd grvtlgptqv flankdsgyp qivdvsnmqk aqeflpkkis
     2341 gdmrgiqykw kesesrgerv kskdssfhkl kmkdlkdssi emelrkvtsa ieeaaldsse
     2401 lltnmededd tdetltslln eiaflnqqln ddsvglaelp ssmdtefpgd arrafiskvp
     2461 pgsratfqve hlgtglkelp dvqgesdsis plllhleddd fsenekqlae pasepdvlki
     2521 vidseikdsl lsnkkaidgg kntsglpaep esvsspptlh mktglensns tdtlwrpmpk
     2581 laplglkvan pssdadgqsl kvmpclapia akvgsvghkm nltgndqegr eskvmptlap
     2641 vvaklgnsga spssagk
//
LOCUS       XP_047288256            2609 aa            linear   PRI 05-AUG-2025
DEFINITION  MAX gene-associated protein isoform X18 [Homo sapiens].
ACCESSION   XP_047288256
VERSION     XP_047288256.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432300.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2609
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2609
                     /product="MAX gene-associated protein isoform X18"
                     /calculated_mol_wt=285024
     Region          584..625
                     /region_name="MGA_dom"
                     /note="MGA, conserved domain; pfam16059"
                     /db_xref="CDD:464998"
     Region          <1012..1314
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          1204..>1526
                     /region_name="Atrophin-1"
                     /note="Atrophin-1 family; pfam03154"
                     /db_xref="CDD:460830"
     Region          1969..2033
                     /region_name="bHLHzip_MGA"
                     /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain
                     found in MAX gene-associated protein (MGA) and similar
                     proteins; cd18911"
                     /db_xref="CDD:381481"
     Site            order(1969,1971..1973,1975..1977,1979..1980,1984,
                     2003..2004)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381481"
     Site            order(1983,1986..1987,1989..1990,1993..1995,2005,
                     2008..2009,2012,2014..2016,2018..2019,2021..2022,2025,
                     2028..2029,2032..2033)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381481"
     CDS             1..2609
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /coded_by="XM_047432300.1:674..8503"
                     /db_xref="GeneID:23269"
                     /db_xref="HGNC:HGNC:14010"
                     /db_xref="MIM:616061"
ORIGIN      
        1 mfkldtgkmp vvylepcavt rstvkiselp dnmlstsrkd kssmlaeley lptyiensne
       61 tafclgkese nglrkhspdl rvvqkypllk epqwkypdis dsisterild dskdsvgdsl
      121 sgkedlgrkr ttmlkiataa kvvnanqnas pnvpgkrgrp rklklckagr ppkntgksli
      181 stkntpvspg stfpdvkpdl edvdgvlfvs feskealdih avdgtteess slqasttnds
      241 gyrarisqle keliedlktl rhkqvihpgl qevglklnsv dptmsidlky lgvqlplapa
      301 tsfpfwnltg tnpaspdagf pfvsrtgktn dftkikgwrg kfhsasasrn eggnsesslk
      361 nrsafcsdkl deylenegkl metsmgfssn aptspvvyql ptkstsyvrt ldsvlkkqst
      421 ispstsyslk phsvppvsrk aksqnrqatf sgrtkssyks ilpypvspkq kyshvilgdk
      481 vtknssgiis enqannfvvp tldenifpkq islrqaqqqq qqqqgsrppg lsksqvklmd
      541 ledcalwegk prtyiteera dvslttllta qaslktkpih tiirkrappc nndfcrlgcv
      601 csslalekrq pahcrrpdcm fgctclkrkv vlvkggsktk hfqrkaahrd pvfydtlgee
      661 areeeegire eeeqlkekkk rkkleytice tepeqpvrhy plwvkvegev dpepvyiptp
      721 sviepmkpll lpqpevlspt vkgklltgik sprsytpkpn pvireedkdp vylyfesmmt
      781 carvrvyerk kedqrqpsss sspspsfqqq tschsspenh nnakepdseq qplkqltcdl
      841 eddsdklqek swksscnege ssstsymhqr spggptklie iisdcnweed rnkilsilsq
      901 hinsnmpqsl kvgsfiiela sqrksrgekn ppvyssrvki smpscqdqdd maeksgsetp
      961 dgplspgkme dispvqtdal dsvrerlhgg kglpfyagls pagklvaykr kpssstsgli
     1021 qvasnakvaa srkprtllps tsnskmasss gtatnrpgkn lkafvpakrp iaarpspggv
     1081 ftqfvmskvg alqqkipgvs tpqtlagtqk fsirpspvmv vtpvvssepv qvcspvtaav
     1141 ttttpqvfle nttavtpmta isdvetkett yssgatttgv vevsetntst svtstqstat
     1201 vnltkttgit tpvasvafpk slvaspstit lpvastasts lvvvtaaass smvttptssl
     1261 gsvpiilsgi ngsppvsqrp enaaqipvat pqvspntvkr agprlllipv qqgsptlrpv
     1321 sntqlqghrm vlqpvrspsg mnlfrhpngq ivqllplhql rgsntqpnlq pvmfrnpgsv
     1381 mgirlpapsk psetppssts ssafsvmnpv iqavgsssav nvitqapsll ssgasfvsqa
     1441 gtltlrispp epqsfasktg setkityssg gqpvgtasli plqsgsfall qlpgqkpvps
     1501 silqhvaslq mkresqnpdq kdetnsikre qetkkvlqse geavdpeanv ikqnsgaats
     1561 eetlndsled rgdhldeecl peegcatvkp sehscitgsh tdqdykdvne eygarnrkss
     1621 kekvavlevr tisekasnkt vqnlskvqhq klgdvkveqq kgfdnpeens sefpvtfkee
     1681 skfelsgskv meqqsnlqpe akekecgdsl ekdrerwrkh lkgpltrkcv gasqeckkea
     1741 deqliketkt cqensdvfqq eqgisdllgk sgitedarvl ktecdswsri snpsafsivp
     1801 rraakssrgn ghfqghlllp geqiqpkqek kggrssadft vldleedded dnektddsid
     1861 eivdvvsdyq seevddvekv nncveyiedd eehvdietve elseeinvah lkttaahtqs
     1921 fkqpscthis adekaaersr kappiplklk pdywsdklqk eaeafayyrr thtanerrrr
     1981 gemrdlfekl kitlgllhss kvsksliltr afseiqgltd qadkligqkn lltrkrnili
     2041 rkvsslsgkt eevvlkkley iyakqqalea qkrkkkmgsd efdisprisk qqegssassv
     2101 dlgqmfinnr rgkplilsrk kdqatentsp lntphtsanl vmtpqgqllt lkgplfsgpv
     2161 vavspdlles dlkpqvagsa valpenddlf mmprivnvts lategglvdm ggskyphevp
     2221 dskpsdhlkd tvrnednsle dkgrissrgn rdgrvtlgpt qvflankdsg ypqivdvsnm
     2281 qkaqeflpkk isgdmrgiqy kwkesesrge rvkskdssfh klkmkdlkds siemelrkvt
     2341 saieeaalds selltnmede ddtdetltsl lneiaflnqq lnddsvglae lpssmdtefp
     2401 gdarrafisk vppgsratfq vehlgtglke lpdvqgesds isplllhled ddfsenekql
     2461 aepasepdvl kividseikd sllsnkkaid ggkntsglpa epesvssppt lhmktglens
     2521 nstdtlwrpm pklaplglkv anpssdadgq slkvmpclap iaakvgsvgh kmnltgndqe
     2581 greskvmptl apvvaklgns gaspssagk
//
LOCUS       XP_047288257            2608 aa            linear   PRI 05-AUG-2025
DEFINITION  MAX gene-associated protein isoform X19 [Homo sapiens].
ACCESSION   XP_047288257
VERSION     XP_047288257.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432301.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2608
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2608
                     /product="MAX gene-associated protein isoform X19"
                     /calculated_mol_wt=284925
     Region          584..625
                     /region_name="MGA_dom"
                     /note="MGA, conserved domain; pfam16059"
                     /db_xref="CDD:464998"
     Region          <1012..1314
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          1204..>1526
                     /region_name="Atrophin-1"
                     /note="Atrophin-1 family; pfam03154"
                     /db_xref="CDD:460830"
     Region          1968..2032
                     /region_name="bHLHzip_MGA"
                     /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain
                     found in MAX gene-associated protein (MGA) and similar
                     proteins; cd18911"
                     /db_xref="CDD:381481"
     Site            order(1968,1970..1972,1974..1976,1978..1979,1983,
                     2002..2003)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381481"
     Site            order(1982,1985..1986,1988..1989,1992..1994,2004,
                     2007..2008,2011,2013..2015,2017..2018,2020..2021,2024,
                     2027..2028,2031..2032)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381481"
     CDS             1..2608
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /coded_by="XM_047432301.1:383..8209"
                     /db_xref="GeneID:23269"
                     /db_xref="HGNC:HGNC:14010"
                     /db_xref="MIM:616061"
ORIGIN      
        1 mfkldtgkmp vvylepcavt rstvkiselp dnmlstsrkd kssmlaeley lptyiensne
       61 tafclgkese nglrkhspdl rvvqkypllk epqwkypdis dsisterild dskdsvgdsl
      121 sgkedlgrkr ttmlkiataa kvvnanqnas pnvpgkrgrp rklklckagr ppkntgksli
      181 stkntpvspg stfpdvkpdl edvdgvlfvs feskealdih avdgtteess slqasttnds
      241 gyrarisqle keliedlktl rhkqvihpgl qevglklnsv dptmsidlky lgvqlplapa
      301 tsfpfwnltg tnpaspdagf pfvsrtgktn dftkikgwrg kfhsasasrn eggnsesslk
      361 nrsafcsdkl deylenegkl metsmgfssn aptspvvyql ptkstsyvrt ldsvlkkqst
      421 ispstsyslk phsvppvsrk aksqnrqatf sgrtkssyks ilpypvspkq kyshvilgdk
      481 vtknssgiis enqannfvvp tldenifpkq islrqaqqqq qqqqgsrppg lsksqvklmd
      541 ledcalwegk prtyiteera dvslttllta qaslktkpih tiirkrappc nndfcrlgcv
      601 csslalekrq pahcrrpdcm fgctclkrkv vlvkggsktk hfqrkaahrd pvfydtlgee
      661 areeeegire eeeqlkekkk rkkleytice tepeqpvrhy plwvkvegev dpepvyiptp
      721 sviepmkpll lpqpevlspt vkgklltgik sprsytpkpn pvireedkdp vylyfesmmt
      781 carvrvyerk kedqrqpsss sspspsfqqq tschsspenh nnakepdseq qplkqltcdl
      841 eddsdklqek swksscnege ssstsymhqr spggptklie iisdcnweed rnkilsilsq
      901 hinsnmpqsl kvgsfiiela sqrksrgekn ppvyssrvki smpscqdqdd maeksgsetp
      961 dgplspgkme dispvqtdal dsvrerlhgg kglpfyagls pagklvaykr kpssstsgli
     1021 qvasnakvaa srkprtllps tsnskmasss gtatnrpgkn lkafvpakrp iaarpspggv
     1081 ftqfvmskvg alqqkipgvs tpqtlagtqk fsirpspvmv vtpvvssepv qvcspvtaav
     1141 ttttpqvfle nttavtpmta isdvetkett yssgatttgv vevsetntst svtstqstat
     1201 vnltkttgit tpvasvafpk slvaspstit lpvastasts lvvvtaaass smvttptssl
     1261 gsvpiilsgi ngsppvsqrp enaaqipvat pqvspntvkr agprlllipv qqgsptlrpv
     1321 sntqlqghrm vlqpvrspsg mnlfrhpngq ivqllplhql rgsntqpnlq pvmfrnpgsv
     1381 mgirlpapsk psetppssts ssafsvmnpv iqavgsssav nvitqapsll ssgasfvsqa
     1441 gtltlrispp epqsfasktg setkityssg gqpvgtasli plqsgsfall qlpgqkpvps
     1501 silqhvaslq mkresqnpdq kdetnsikre qetkkvlqse geavdpeanv ikqnsgaats
     1561 eetlndsled rgdhldeecl peegcatvkp sehscitgsh tdqdykdvne eygarnrkss
     1621 kekvavlevr tisekasnkt vqnlskvqhq klgdvkveqq kgfdnpeens sefpvtfkee
     1681 skfelsgskv meqqsnlqpe akekecgdsl ekdrerwrkh lkgpltrkcv gasqeckkea
     1741 deqliketkt cqensdvfqq eqgisdllgk sgitedarvl ktecdswsri snpsafsivp
     1801 rraakssrgn ghfqghlllp geqiqpkqek kggrssadft vldleedded dnektddsid
     1861 eivdvvsdyq seevddvekn ncveyiedde ehvdietvee lseeinvahl kttaahtqsf
     1921 kqpscthisa dekaaersrk appiplklkp dywsdklqke aeafayyrrt htanerrrrg
     1981 emrdlfeklk itlgllhssk vsksliltra fseiqgltdq adkligqknl ltrkrnilir
     2041 kvsslsgkte evvlkkleyi yakqqaleaq krkkkmgsde fdispriskq qegssassvd
     2101 lgqmfinnrr gkplilsrkk dqatentspl ntphtsanlv mtpqgqlltl kgplfsgpvv
     2161 avspdllesd lkpqvagsav alpenddlfm mprivnvtsl ategglvdmg gskyphevpd
     2221 skpsdhlkdt vrnednsled kgrissrgnr dgrvtlgptq vflankdsgy pqivdvsnmq
     2281 kaqeflpkki sgdmrgiqyk wkesesrger vkskdssfhk lkmkdlkdss iemelrkvts
     2341 aieeaaldss elltnmeded dtdetltsll neiaflnqql nddsvglael pssmdtefpg
     2401 darrafiskv ppgsratfqv ehlgtglkel pdvqgesdsi splllhledd dfsenekqla
     2461 epasepdvlk ividseikds llsnkkaidg gkntsglpae pesvsspptl hmktglensn
     2521 stdtlwrpmp klaplglkva npssdadgqs lkvmpclapi aakvgsvghk mnltgndqeg
     2581 reskvmptla pvvaklgnsg aspssagk
//
LOCUS       XP_047288258            2608 aa            linear   PRI 05-AUG-2025
DEFINITION  MAX gene-associated protein isoform X19 [Homo sapiens].
ACCESSION   XP_047288258
VERSION     XP_047288258.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432302.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2608
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2608
                     /product="MAX gene-associated protein isoform X19"
                     /calculated_mol_wt=284925
     Region          584..625
                     /region_name="MGA_dom"
                     /note="MGA, conserved domain; pfam16059"
                     /db_xref="CDD:464998"
     Region          <1012..1314
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          1204..>1526
                     /region_name="Atrophin-1"
                     /note="Atrophin-1 family; pfam03154"
                     /db_xref="CDD:460830"
     Region          1968..2032
                     /region_name="bHLHzip_MGA"
                     /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain
                     found in MAX gene-associated protein (MGA) and similar
                     proteins; cd18911"
                     /db_xref="CDD:381481"
     Site            order(1968,1970..1972,1974..1976,1978..1979,1983,
                     2002..2003)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381481"
     Site            order(1982,1985..1986,1988..1989,1992..1994,2004,
                     2007..2008,2011,2013..2015,2017..2018,2020..2021,2024,
                     2027..2028,2031..2032)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381481"
     CDS             1..2608
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /coded_by="XM_047432302.1:674..8500"
                     /db_xref="GeneID:23269"
                     /db_xref="HGNC:HGNC:14010"
                     /db_xref="MIM:616061"
ORIGIN      
        1 mfkldtgkmp vvylepcavt rstvkiselp dnmlstsrkd kssmlaeley lptyiensne
       61 tafclgkese nglrkhspdl rvvqkypllk epqwkypdis dsisterild dskdsvgdsl
      121 sgkedlgrkr ttmlkiataa kvvnanqnas pnvpgkrgrp rklklckagr ppkntgksli
      181 stkntpvspg stfpdvkpdl edvdgvlfvs feskealdih avdgtteess slqasttnds
      241 gyrarisqle keliedlktl rhkqvihpgl qevglklnsv dptmsidlky lgvqlplapa
      301 tsfpfwnltg tnpaspdagf pfvsrtgktn dftkikgwrg kfhsasasrn eggnsesslk
      361 nrsafcsdkl deylenegkl metsmgfssn aptspvvyql ptkstsyvrt ldsvlkkqst
      421 ispstsyslk phsvppvsrk aksqnrqatf sgrtkssyks ilpypvspkq kyshvilgdk
      481 vtknssgiis enqannfvvp tldenifpkq islrqaqqqq qqqqgsrppg lsksqvklmd
      541 ledcalwegk prtyiteera dvslttllta qaslktkpih tiirkrappc nndfcrlgcv
      601 csslalekrq pahcrrpdcm fgctclkrkv vlvkggsktk hfqrkaahrd pvfydtlgee
      661 areeeegire eeeqlkekkk rkkleytice tepeqpvrhy plwvkvegev dpepvyiptp
      721 sviepmkpll lpqpevlspt vkgklltgik sprsytpkpn pvireedkdp vylyfesmmt
      781 carvrvyerk kedqrqpsss sspspsfqqq tschsspenh nnakepdseq qplkqltcdl
      841 eddsdklqek swksscnege ssstsymhqr spggptklie iisdcnweed rnkilsilsq
      901 hinsnmpqsl kvgsfiiela sqrksrgekn ppvyssrvki smpscqdqdd maeksgsetp
      961 dgplspgkme dispvqtdal dsvrerlhgg kglpfyagls pagklvaykr kpssstsgli
     1021 qvasnakvaa srkprtllps tsnskmasss gtatnrpgkn lkafvpakrp iaarpspggv
     1081 ftqfvmskvg alqqkipgvs tpqtlagtqk fsirpspvmv vtpvvssepv qvcspvtaav
     1141 ttttpqvfle nttavtpmta isdvetkett yssgatttgv vevsetntst svtstqstat
     1201 vnltkttgit tpvasvafpk slvaspstit lpvastasts lvvvtaaass smvttptssl
     1261 gsvpiilsgi ngsppvsqrp enaaqipvat pqvspntvkr agprlllipv qqgsptlrpv
     1321 sntqlqghrm vlqpvrspsg mnlfrhpngq ivqllplhql rgsntqpnlq pvmfrnpgsv
     1381 mgirlpapsk psetppssts ssafsvmnpv iqavgsssav nvitqapsll ssgasfvsqa
     1441 gtltlrispp epqsfasktg setkityssg gqpvgtasli plqsgsfall qlpgqkpvps
     1501 silqhvaslq mkresqnpdq kdetnsikre qetkkvlqse geavdpeanv ikqnsgaats
     1561 eetlndsled rgdhldeecl peegcatvkp sehscitgsh tdqdykdvne eygarnrkss
     1621 kekvavlevr tisekasnkt vqnlskvqhq klgdvkveqq kgfdnpeens sefpvtfkee
     1681 skfelsgskv meqqsnlqpe akekecgdsl ekdrerwrkh lkgpltrkcv gasqeckkea
     1741 deqliketkt cqensdvfqq eqgisdllgk sgitedarvl ktecdswsri snpsafsivp
     1801 rraakssrgn ghfqghlllp geqiqpkqek kggrssadft vldleedded dnektddsid
     1861 eivdvvsdyq seevddvekn ncveyiedde ehvdietvee lseeinvahl kttaahtqsf
     1921 kqpscthisa dekaaersrk appiplklkp dywsdklqke aeafayyrrt htanerrrrg
     1981 emrdlfeklk itlgllhssk vsksliltra fseiqgltdq adkligqknl ltrkrnilir
     2041 kvsslsgkte evvlkkleyi yakqqaleaq krkkkmgsde fdispriskq qegssassvd
     2101 lgqmfinnrr gkplilsrkk dqatentspl ntphtsanlv mtpqgqlltl kgplfsgpvv
     2161 avspdllesd lkpqvagsav alpenddlfm mprivnvtsl ategglvdmg gskyphevpd
     2221 skpsdhlkdt vrnednsled kgrissrgnr dgrvtlgptq vflankdsgy pqivdvsnmq
     2281 kaqeflpkki sgdmrgiqyk wkesesrger vkskdssfhk lkmkdlkdss iemelrkvts
     2341 aieeaaldss elltnmeded dtdetltsll neiaflnqql nddsvglael pssmdtefpg
     2401 darrafiskv ppgsratfqv ehlgtglkel pdvqgesdsi splllhledd dfsenekqla
     2461 epasepdvlk ividseikds llsnkkaidg gkntsglpae pesvsspptl hmktglensn
     2521 stdtlwrpmp klaplglkva npssdadgqs lkvmpclapi aakvgsvghk mnltgndqeg
     2581 reskvmptla pvvaklgnsg aspssagk
//
LOCUS       XP_047288259            2547 aa            linear   PRI 05-AUG-2025
DEFINITION  MAX gene-associated protein isoform X20 [Homo sapiens].
ACCESSION   XP_047288259
VERSION     XP_047288259.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432303.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2547
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2547
                     /product="MAX gene-associated protein isoform X20"
                     /calculated_mol_wt=278409
     Region          584..625
                     /region_name="MGA_dom"
                     /note="MGA, conserved domain; pfam16059"
                     /db_xref="CDD:464998"
     Region          <952..1253
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          1143..>1465
                     /region_name="Atrophin-1"
                     /note="Atrophin-1 family; pfam03154"
                     /db_xref="CDD:460830"
     Region          1907..1971
                     /region_name="bHLHzip_MGA"
                     /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain
                     found in MAX gene-associated protein (MGA) and similar
                     proteins; cd18911"
                     /db_xref="CDD:381481"
     Site            order(1907,1909..1911,1913..1915,1917..1918,1922,
                     1941..1942)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381481"
     Site            order(1921,1924..1925,1927..1928,1931..1933,1943,
                     1946..1947,1950,1952..1954,1956..1957,1959..1960,1963,
                     1966..1967,1970..1971)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381481"
     CDS             1..2547
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /coded_by="XM_047432303.1:383..8026"
                     /db_xref="GeneID:23269"
                     /db_xref="HGNC:HGNC:14010"
                     /db_xref="MIM:616061"
ORIGIN      
        1 mfkldtgkmp vvylepcavt rstvkiselp dnmlstsrkd kssmlaeley lptyiensne
       61 tafclgkese nglrkhspdl rvvqkypllk epqwkypdis dsisterild dskdsvgdsl
      121 sgkedlgrkr ttmlkiataa kvvnanqnas pnvpgkrgrp rklklckagr ppkntgksli
      181 stkntpvspg stfpdvkpdl edvdgvlfvs feskealdih avdgtteess slqasttnds
      241 gyrarisqle keliedlktl rhkqvihpgl qevglklnsv dptmsidlky lgvqlplapa
      301 tsfpfwnltg tnpaspdagf pfvsrtgktn dftkikgwrg kfhsasasrn eggnsesslk
      361 nrsafcsdkl deylenegkl metsmgfssn aptspvvyql ptkstsyvrt ldsvlkkqst
      421 ispstsyslk phsvppvsrk aksqnrqatf sgrtkssyks ilpypvspkq kyshvilgdk
      481 vtknssgiis enqannfvvp tldenifpkq islrqaqqqq qqqqgsrppg lsksqvklmd
      541 ledcalwegk prtyiteera dvslttllta qaslktkpih tiirkrappc nndfcrlgcv
      601 csslalekrq pahcrrpdcm fgctclkrkv vlvkggsktk hfqrkaahrd pvfydtlgee
      661 areeeegire eeeqlkekkk rkkleytice tepeqpvrhy plwvkvegev dpepvyiptp
      721 sviepmkpll lpqpevlspt vkgklltgik sprsytpkpn pvireedkdp vylyfesmmt
      781 carvrvyerk kedqrqpsss sspspsfqqq tschsspenh nnakepdseq qplkqltcdl
      841 eddsdklqek swksscnege ssstsymhqr spggptklie iisdcnweed rnkilsilsq
      901 hinsnmpqsl kvngksypqa klllgqmgal hpanrlaayi tgrlrpsvld lstlstvisk
      961 vasnakvaas rkprtllpst snskmasssg tatnrpgknl kafvpakrpi aarpspggvf
     1021 tqfvmskvga lqqkipgvst pqtlagtqkf sirpspvmvv tpvvssepvq vcspvtaavt
     1081 tttpqvflen ttavtpmtai sdvetketty ssgatttgvv evsetntsts vtstqstatv
     1141 nltkttgitt pvasvafpks lvaspstitl pvastastsl vvvtaaasss mvttptsslg
     1201 svpiilsgin gsppvsqrpe naaqipvatp qvspntvkra gprlllipvq qgsptlrpvs
     1261 ntqlqghrmv lqpvrspsgm nlfrhpngqi vqllplhqlr gsntqpnlqp vmfrnpgsvm
     1321 girlpapskp setppsstss safsvmnpvi qavgsssavn vitqapslls sgasfvsqag
     1381 tltlrisppe pqsfasktgs etkityssgg qpvgtaslip lqsgsfallq lpgqkpvpss
     1441 ilqhvaslqm kresqnpdqk detnsikreq etkkvlqseg eavdpeanvi kqnsgaatse
     1501 etlndsledr gdhldeeclp eegcatvkps ehscitgsht dqdykdvnee ygarnrkssk
     1561 ekvavlevrt isekasnktv qnlskvqhqk lgdvkveqqk gfdnpeenss efpvtfkees
     1621 kfelsgskvm eqqsnlqpea kekecgdsle kdrerwrkhl kgpltrkcvg asqeckkead
     1681 eqliketktc qensdvfqqe qgisdllgks gitedarvlk tecdswsris npsafsivpr
     1741 raakssrgng hfqghlllpg eqiqpkqekk ggrssadftv ldleeddedd nektddside
     1801 ivdvvsdyqs eevddveknn cveyieddee hvdietveel seeinvahlk ttaahtqsfk
     1861 qpscthisad ekaaersrka ppiplklkpd ywsdklqkea eafayyrrth tanerrrrge
     1921 mrdlfeklki tlgllhsskv sksliltraf seiqgltdqa dkligqknll trkrnilirk
     1981 vsslsgktee vvlkkleyiy akqqaleaqk rkkkmgsdef dispriskqq egssassvdl
     2041 gqmfinnrrg kplilsrkkd qatentspln tphtsanlvm tpqgqlltlk gplfsgpvva
     2101 vspdllesdl kpqvagsava lpenddlfmm privnvtsla tegglvdmgg skyphevpds
     2161 kpsdhlkdtv rnednsledk grissrgnrd grvtlgptqv flankdsgyp qivdvsnmqk
     2221 aqeflpkkis gdmrgiqykw kesesrgerv kskdssfhkl kmkdlkdssi emelrkvtsa
     2281 ieeaaldsse lltnmededd tdetltslln eiaflnqqln ddsvglaelp ssmdtefpgd
     2341 arrafiskvp pgsratfqve hlgtglkelp dvqgesdsis plllhleddd fsenekqlae
     2401 pasepdvlki vidseikdsl lsnkkaidgg kntsglpaep esvsspptlh mktglensns
     2461 tdtlwrpmpk laplglkvan pssdadgqsl kvmpclapia akvgsvghkm nltgndqegr
     2521 eskvmptlap vvaklgnsga spssagk
//
LOCUS       XP_047288260            2498 aa            linear   PRI 05-AUG-2025
DEFINITION  MAX gene-associated protein isoform X21 [Homo sapiens].
ACCESSION   XP_047288260
VERSION     XP_047288260.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432304.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2498
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2498
                     /product="MAX gene-associated protein isoform X21"
                     /calculated_mol_wt=273206
     Region          584..625
                     /region_name="MGA_dom"
                     /note="MGA, conserved domain; pfam16059"
                     /db_xref="CDD:464998"
     Region          920..>1238
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          1094..>1416
                     /region_name="Atrophin-1"
                     /note="Atrophin-1 family; pfam03154"
                     /db_xref="CDD:460830"
     Region          1858..1922
                     /region_name="bHLHzip_MGA"
                     /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain
                     found in MAX gene-associated protein (MGA) and similar
                     proteins; cd18911"
                     /db_xref="CDD:381481"
     Site            order(1858,1860..1862,1864..1866,1868..1869,1873,
                     1892..1893)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381481"
     Site            order(1872,1875..1876,1878..1879,1882..1884,1894,
                     1897..1898,1901,1903..1905,1907..1908,1910..1911,1914,
                     1917..1918,1921..1922)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381481"
     CDS             1..2498
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /coded_by="XM_047432304.1:383..7879"
                     /db_xref="GeneID:23269"
                     /db_xref="HGNC:HGNC:14010"
                     /db_xref="MIM:616061"
ORIGIN      
        1 mfkldtgkmp vvylepcavt rstvkiselp dnmlstsrkd kssmlaeley lptyiensne
       61 tafclgkese nglrkhspdl rvvqkypllk epqwkypdis dsisterild dskdsvgdsl
      121 sgkedlgrkr ttmlkiataa kvvnanqnas pnvpgkrgrp rklklckagr ppkntgksli
      181 stkntpvspg stfpdvkpdl edvdgvlfvs feskealdih avdgtteess slqasttnds
      241 gyrarisqle keliedlktl rhkqvihpgl qevglklnsv dptmsidlky lgvqlplapa
      301 tsfpfwnltg tnpaspdagf pfvsrtgktn dftkikgwrg kfhsasasrn eggnsesslk
      361 nrsafcsdkl deylenegkl metsmgfssn aptspvvyql ptkstsyvrt ldsvlkkqst
      421 ispstsyslk phsvppvsrk aksqnrqatf sgrtkssyks ilpypvspkq kyshvilgdk
      481 vtknssgiis enqannfvvp tldenifpkq islrqaqqqq qqqqgsrppg lsksqvklmd
      541 ledcalwegk prtyiteera dvslttllta qaslktkpih tiirkrappc nndfcrlgcv
      601 csslalekrq pahcrrpdcm fgctclkrkv vlvkggsktk hfqrkaahrd pvfydtlgee
      661 areeeegire eeeqlkekkk rkkleytice tepeqpvrhy plwvkvegev dpepvyiptp
      721 sviepmkpll lpqpevlspt vkgklltgik sprsytpkpn pvireedkdp vylyfesmmt
      781 carvrvyerk kedqrqpsss sspspsfqqq tschsspenh nnakepdseq qplkqltcdl
      841 eddsdklqek swksscnege ssstsymhqr spggptklie iisdcnweed rnkilsilsq
      901 hinsnmpqsl kvasnakvaa srkprtllps tsnskmasss gtatnrpgkn lkafvpakrp
      961 iaarpspggv ftqfvmskvg alqqkipgvs tpqtlagtqk fsirpspvmv vtpvvssepv
     1021 qvcspvtaav ttttpqvfle nttavtpmta isdvetkett yssgatttgv vevsetntst
     1081 svtstqstat vnltkttgit tpvasvafpk slvaspstit lpvastasts lvvvtaaass
     1141 smvttptssl gsvpiilsgi ngsppvsqrp enaaqipvat pqvspntvkr agprlllipv
     1201 qqgsptlrpv sntqlqghrm vlqpvrspsg mnlfrhpngq ivqllplhql rgsntqpnlq
     1261 pvmfrnpgsv mgirlpapsk psetppssts ssafsvmnpv iqavgsssav nvitqapsll
     1321 ssgasfvsqa gtltlrispp epqsfasktg setkityssg gqpvgtasli plqsgsfall
     1381 qlpgqkpvps silqhvaslq mkresqnpdq kdetnsikre qetkkvlqse geavdpeanv
     1441 ikqnsgaats eetlndsled rgdhldeecl peegcatvkp sehscitgsh tdqdykdvne
     1501 eygarnrkss kekvavlevr tisekasnkt vqnlskvqhq klgdvkveqq kgfdnpeens
     1561 sefpvtfkee skfelsgskv meqqsnlqpe akekecgdsl ekdrerwrkh lkgpltrkcv
     1621 gasqeckkea deqliketkt cqensdvfqq eqgisdllgk sgitedarvl ktecdswsri
     1681 snpsafsivp rraakssrgn ghfqghlllp geqiqpkqek kggrssadft vldleedded
     1741 dnektddsid eivdvvsdyq seevddvekn ncveyiedde ehvdietvee lseeinvahl
     1801 kttaahtqsf kqpscthisa dekaaersrk appiplklkp dywsdklqke aeafayyrrt
     1861 htanerrrrg emrdlfeklk itlgllhssk vsksliltra fseiqgltdq adkligqknl
     1921 ltrkrnilir kvsslsgkte evvlkkleyi yakqqaleaq krkkkmgsde fdispriskq
     1981 qegssassvd lgqmfinnrr gkplilsrkk dqatentspl ntphtsanlv mtpqgqlltl
     2041 kgplfsgpvv avspdllesd lkpqvagsav alpenddlfm mprivnvtsl ategglvdmg
     2101 gskyphevpd skpsdhlkdt vrnednsled kgrissrgnr dgrvtlgptq vflankdsgy
     2161 pqivdvsnmq kaqeflpkki sgdmrgiqyk wkesesrger vkskdssfhk lkmkdlkdss
     2221 iemelrkvts aieeaaldss elltnmeded dtdetltsll neiaflnqql nddsvglael
     2281 pssmdtefpg darrafiskv ppgsratfqv ehlgtglkel pdvqgesdsi splllhledd
     2341 dfsenekqla epasepdvlk ividseikds llsnkkaidg gkntsglpae pesvsspptl
     2401 hmktglensn stdtlwrpmp klaplglkva npssdadgqs lkvmpclapi aakvgsvghk
     2461 mnltgndqeg reskvmptla pvvaklgnsg aspssagk
//
LOCUS       XP_047288261            2449 aa            linear   PRI 05-AUG-2025
DEFINITION  MAX gene-associated protein isoform X22 [Homo sapiens].
ACCESSION   XP_047288261
VERSION     XP_047288261.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432305.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2449
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2449
                     /product="MAX gene-associated protein isoform X22"
                     /calculated_mol_wt=269286
     Region          584..625
                     /region_name="MGA_dom"
                     /note="MGA, conserved domain; pfam16059"
                     /db_xref="CDD:464998"
     Region          1809..1873
                     /region_name="bHLHzip_MGA"
                     /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain
                     found in MAX gene-associated protein (MGA) and similar
                     proteins; cd18911"
                     /db_xref="CDD:381481"
     Site            order(1809,1811..1813,1815..1817,1819..1820,1824,
                     1843..1844)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381481"
     Site            order(1823,1826..1827,1829..1830,1833..1835,1845,
                     1848..1849,1852,1854..1856,1858..1859,1861..1862,1865,
                     1868..1869,1872..1873)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381481"
     CDS             1..2449
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /coded_by="XM_047432305.1:383..7732"
                     /db_xref="GeneID:23269"
                     /db_xref="HGNC:HGNC:14010"
                     /db_xref="MIM:616061"
ORIGIN      
        1 mfkldtgkmp vvylepcavt rstvkiselp dnmlstsrkd kssmlaeley lptyiensne
       61 tafclgkese nglrkhspdl rvvqkypllk epqwkypdis dsisterild dskdsvgdsl
      121 sgkedlgrkr ttmlkiataa kvvnanqnas pnvpgkrgrp rklklckagr ppkntgksli
      181 stkntpvspg stfpdvkpdl edvdgvlfvs feskealdih avdgtteess slqasttnds
      241 gyrarisqle keliedlktl rhkqvihpgl qevglklnsv dptmsidlky lgvqlplapa
      301 tsfpfwnltg tnpaspdagf pfvsrtgktn dftkikgwrg kfhsasasrn eggnsesslk
      361 nrsafcsdkl deylenegkl metsmgfssn aptspvvyql ptkstsyvrt ldsvlkkqst
      421 ispstsyslk phsvppvsrk aksqnrqatf sgrtkssyks ilpypvspkq kyshvilgdk
      481 vtknssgiis enqannfvvp tldenifpkq islrqaqqqq qqqqgsrppg lsksqvklmd
      541 ledcalwegk prtyiteera dvslttllta qaslktkpih tiirkrappc nndfcrlgcv
      601 csslalekrq pahcrrpdcm fgctclkrkv vlvkggsktk hfqrkaahrd pvfydtlgee
      661 areeeegire eeeqlkekkk rkkleytice tepeqpvrhy plwvkvegev dpepvyiptp
      721 sviepmkpll lpqpevlspt vkgklltgik sprsytpkpn pvireedkdp vylyfesmmt
      781 carvrvyerk kedqrqpsss sspspsfqqq tschsspenh nnakepdseq qplkqltcdl
      841 eddsdklqek swksscnege ssstsymhqr spggptklie iisdcnweed rnkilsilsq
      901 hinsnmpqsl kvgsfiiela sqrksrgekn ppvyssrvki smpscqdqdd maeksgsetp
      961 dgplspgkme dispvqtdal dsvrerlhgg kglpfyagls pagklvaykr kpssstsgli
     1021 qvngksypqa klllgqmgal hpanrlaayi tgrlrpsvld lstlstvisk vasnakvaas
     1081 rkprtllpst snskmasssg tatnrpgknl kafvpakrpi enaaqipvat pqvspntvkr
     1141 agprlllipv qqgsptlrpv sntqlqghrm vlqpvrspsg mnlfrhpngq ivqllplhql
     1201 rgsntqpnlq pvmfrnpgsv mgirlpapsk psetppssts ssafsvmnpv iqavgsssav
     1261 nvitqapsll ssgasfvsqa gtltlrispp epqsfasktg setkityssg gqpvgtasli
     1321 plqsgsfall qlpgqkpvps silqhvaslq mkresqnpdq kdetnsikre qetkkvlqse
     1381 geavdpeanv ikqnsgaats eetlndsled rgdhldeecl peegcatvkp sehscitgsh
     1441 tdqdykdvne eygarnrkss kekvavlevr tisekasnkt vqnlskvqhq klgdvkveqq
     1501 kgfdnpeens sefpvtfkee skfelsgskv meqqsnlqpe akekecgdsl ekdrerwrkh
     1561 lkgpltrkcv gasqeckkea deqliketkt cqensdvfqq eqgisdllgk sgitedarvl
     1621 ktecdswsri snpsafsivp rraakssrgn ghfqghlllp geqiqpkqek kggrssadft
     1681 vldleedded dnektddsid eivdvvsdyq seevddvekv nncveyiedd eehvdietve
     1741 elseeinvah lkttaahtqs fkqpscthis adekaaersr kappiplklk pdywsdklqk
     1801 eaeafayyrr thtanerrrr gemrdlfekl kitlgllhss kvsksliltr afseiqgltd
     1861 qadkligqkn lltrkrnili rkvsslsgkt eevvlkkley iyakqqalea qkrkkkmgsd
     1921 efdisprisk qqegssassv dlgqmfinnr rgkplilsrk kdqatentsp lntphtsanl
     1981 vmtpqgqllt lkgplfsgpv vavspdlles dlkpqvagsa valpenddlf mmprivnvts
     2041 lategglvdm ggskyphevp dskpsdhlkd tvrnednsle dkgrissrgn rdgrvtlgpt
     2101 qvflankdsg ypqivdvsnm qkaqeflpkk isgdmrgiqy kwkesesrge rvkskdssfh
     2161 klkmkdlkds siemelrkvt saieeaalds selltnmede ddtdetltsl lneiaflnqq
     2221 lnddsvglae lpssmdtefp gdarrafisk vppgsratfq vehlgtglke lpdvqgesds
     2281 isplllhled ddfsenekql aepasepdvl kividseikd sllsnkkaid ggkntsglpa
     2341 epesvssppt lhmktglens nstdtlwrpm pklaplglkv anpssdadgq slkvmpclap
     2401 iaakvgsvgh kmnltgndqe greskvmptl apvvaklgns gaspssagk
//
LOCUS       XP_047288262            2448 aa            linear   PRI 05-AUG-2025
DEFINITION  MAX gene-associated protein isoform X23 [Homo sapiens].
ACCESSION   XP_047288262
VERSION     XP_047288262.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432306.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2448
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2448
                     /product="MAX gene-associated protein isoform X23"
                     /calculated_mol_wt=269187
     Region          584..625
                     /region_name="MGA_dom"
                     /note="MGA, conserved domain; pfam16059"
                     /db_xref="CDD:464998"
     Region          1808..1872
                     /region_name="bHLHzip_MGA"
                     /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain
                     found in MAX gene-associated protein (MGA) and similar
                     proteins; cd18911"
                     /db_xref="CDD:381481"
     Site            order(1808,1810..1812,1814..1816,1818..1819,1823,
                     1842..1843)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381481"
     Site            order(1822,1825..1826,1828..1829,1832..1834,1844,
                     1847..1848,1851,1853..1855,1857..1858,1860..1861,1864,
                     1867..1868,1871..1872)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381481"
     CDS             1..2448
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /coded_by="XM_047432306.1:383..7729"
                     /db_xref="GeneID:23269"
                     /db_xref="HGNC:HGNC:14010"
                     /db_xref="MIM:616061"
ORIGIN      
        1 mfkldtgkmp vvylepcavt rstvkiselp dnmlstsrkd kssmlaeley lptyiensne
       61 tafclgkese nglrkhspdl rvvqkypllk epqwkypdis dsisterild dskdsvgdsl
      121 sgkedlgrkr ttmlkiataa kvvnanqnas pnvpgkrgrp rklklckagr ppkntgksli
      181 stkntpvspg stfpdvkpdl edvdgvlfvs feskealdih avdgtteess slqasttnds
      241 gyrarisqle keliedlktl rhkqvihpgl qevglklnsv dptmsidlky lgvqlplapa
      301 tsfpfwnltg tnpaspdagf pfvsrtgktn dftkikgwrg kfhsasasrn eggnsesslk
      361 nrsafcsdkl deylenegkl metsmgfssn aptspvvyql ptkstsyvrt ldsvlkkqst
      421 ispstsyslk phsvppvsrk aksqnrqatf sgrtkssyks ilpypvspkq kyshvilgdk
      481 vtknssgiis enqannfvvp tldenifpkq islrqaqqqq qqqqgsrppg lsksqvklmd
      541 ledcalwegk prtyiteera dvslttllta qaslktkpih tiirkrappc nndfcrlgcv
      601 csslalekrq pahcrrpdcm fgctclkrkv vlvkggsktk hfqrkaahrd pvfydtlgee
      661 areeeegire eeeqlkekkk rkkleytice tepeqpvrhy plwvkvegev dpepvyiptp
      721 sviepmkpll lpqpevlspt vkgklltgik sprsytpkpn pvireedkdp vylyfesmmt
      781 carvrvyerk kedqrqpsss sspspsfqqq tschsspenh nnakepdseq qplkqltcdl
      841 eddsdklqek swksscnege ssstsymhqr spggptklie iisdcnweed rnkilsilsq
      901 hinsnmpqsl kvgsfiiela sqrksrgekn ppvyssrvki smpscqdqdd maeksgsetp
      961 dgplspgkme dispvqtdal dsvrerlhgg kglpfyagls pagklvaykr kpssstsgli
     1021 qvngksypqa klllgqmgal hpanrlaayi tgrlrpsvld lstlstvisk vasnakvaas
     1081 rkprtllpst snskmasssg tatnrpgknl kafvpakrpi enaaqipvat pqvspntvkr
     1141 agprlllipv qqgsptlrpv sntqlqghrm vlqpvrspsg mnlfrhpngq ivqllplhql
     1201 rgsntqpnlq pvmfrnpgsv mgirlpapsk psetppssts ssafsvmnpv iqavgsssav
     1261 nvitqapsll ssgasfvsqa gtltlrispp epqsfasktg setkityssg gqpvgtasli
     1321 plqsgsfall qlpgqkpvps silqhvaslq mkresqnpdq kdetnsikre qetkkvlqse
     1381 geavdpeanv ikqnsgaats eetlndsled rgdhldeecl peegcatvkp sehscitgsh
     1441 tdqdykdvne eygarnrkss kekvavlevr tisekasnkt vqnlskvqhq klgdvkveqq
     1501 kgfdnpeens sefpvtfkee skfelsgskv meqqsnlqpe akekecgdsl ekdrerwrkh
     1561 lkgpltrkcv gasqeckkea deqliketkt cqensdvfqq eqgisdllgk sgitedarvl
     1621 ktecdswsri snpsafsivp rraakssrgn ghfqghlllp geqiqpkqek kggrssadft
     1681 vldleedded dnektddsid eivdvvsdyq seevddvekn ncveyiedde ehvdietvee
     1741 lseeinvahl kttaahtqsf kqpscthisa dekaaersrk appiplklkp dywsdklqke
     1801 aeafayyrrt htanerrrrg emrdlfeklk itlgllhssk vsksliltra fseiqgltdq
     1861 adkligqknl ltrkrnilir kvsslsgkte evvlkkleyi yakqqaleaq krkkkmgsde
     1921 fdispriskq qegssassvd lgqmfinnrr gkplilsrkk dqatentspl ntphtsanlv
     1981 mtpqgqlltl kgplfsgpvv avspdllesd lkpqvagsav alpenddlfm mprivnvtsl
     2041 ategglvdmg gskyphevpd skpsdhlkdt vrnednsled kgrissrgnr dgrvtlgptq
     2101 vflankdsgy pqivdvsnmq kaqeflpkki sgdmrgiqyk wkesesrger vkskdssfhk
     2161 lkmkdlkdss iemelrkvts aieeaaldss elltnmeded dtdetltsll neiaflnqql
     2221 nddsvglael pssmdtefpg darrafiskv ppgsratfqv ehlgtglkel pdvqgesdsi
     2281 splllhledd dfsenekqla epasepdvlk ividseikds llsnkkaidg gkntsglpae
     2341 pesvsspptl hmktglensn stdtlwrpmp klaplglkva npssdadgqs lkvmpclapi
     2401 aakvgsvghk mnltgndqeg reskvmptla pvvaklgnsg aspssagk
//
LOCUS       XP_047288263            2399 aa            linear   PRI 05-AUG-2025
DEFINITION  MAX gene-associated protein isoform X24 [Homo sapiens].
ACCESSION   XP_047288263
VERSION     XP_047288263.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432307.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2399
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2399
                     /product="MAX gene-associated protein isoform X24"
                     /calculated_mol_wt=263984
     Region          584..625
                     /region_name="MGA_dom"
                     /note="MGA, conserved domain; pfam16059"
                     /db_xref="CDD:464998"
     Region          1759..1823
                     /region_name="bHLHzip_MGA"
                     /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain
                     found in MAX gene-associated protein (MGA) and similar
                     proteins; cd18911"
                     /db_xref="CDD:381481"
     Site            order(1759,1761..1763,1765..1767,1769..1770,1774,
                     1793..1794)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381481"
     Site            order(1773,1776..1777,1779..1780,1783..1785,1795,
                     1798..1799,1802,1804..1806,1808..1809,1811..1812,1815,
                     1818..1819,1822..1823)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381481"
     CDS             1..2399
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /coded_by="XM_047432307.1:383..7582"
                     /db_xref="GeneID:23269"
                     /db_xref="HGNC:HGNC:14010"
                     /db_xref="MIM:616061"
ORIGIN      
        1 mfkldtgkmp vvylepcavt rstvkiselp dnmlstsrkd kssmlaeley lptyiensne
       61 tafclgkese nglrkhspdl rvvqkypllk epqwkypdis dsisterild dskdsvgdsl
      121 sgkedlgrkr ttmlkiataa kvvnanqnas pnvpgkrgrp rklklckagr ppkntgksli
      181 stkntpvspg stfpdvkpdl edvdgvlfvs feskealdih avdgtteess slqasttnds
      241 gyrarisqle keliedlktl rhkqvihpgl qevglklnsv dptmsidlky lgvqlplapa
      301 tsfpfwnltg tnpaspdagf pfvsrtgktn dftkikgwrg kfhsasasrn eggnsesslk
      361 nrsafcsdkl deylenegkl metsmgfssn aptspvvyql ptkstsyvrt ldsvlkkqst
      421 ispstsyslk phsvppvsrk aksqnrqatf sgrtkssyks ilpypvspkq kyshvilgdk
      481 vtknssgiis enqannfvvp tldenifpkq islrqaqqqq qqqqgsrppg lsksqvklmd
      541 ledcalwegk prtyiteera dvslttllta qaslktkpih tiirkrappc nndfcrlgcv
      601 csslalekrq pahcrrpdcm fgctclkrkv vlvkggsktk hfqrkaahrd pvfydtlgee
      661 areeeegire eeeqlkekkk rkkleytice tepeqpvrhy plwvkvegev dpepvyiptp
      721 sviepmkpll lpqpevlspt vkgklltgik sprsytpkpn pvireedkdp vylyfesmmt
      781 carvrvyerk kedqrqpsss sspspsfqqq tschsspenh nnakepdseq qplkqltcdl
      841 eddsdklqek swksscnege ssstsymhqr spggptklie iisdcnweed rnkilsilsq
      901 hinsnmpqsl kvgsfiiela sqrksrgekn ppvyssrvki smpscqdqdd maeksgsetp
      961 dgplspgkme dispvqtdal dsvrerlhgg kglpfyagls pagklvaykr kpssstsgli
     1021 qvasnakvaa srkprtllps tsnskmasss gtatnrpgkn lkafvpakrp ienaaqipva
     1081 tpqvspntvk ragprlllip vqqgsptlrp vsntqlqghr mvlqpvrsps gmnlfrhpng
     1141 qivqllplhq lrgsntqpnl qpvmfrnpgs vmgirlpaps kpsetppsst sssafsvmnp
     1201 viqavgsssa vnvitqapsl lssgasfvsq agtltlrisp pepqsfaskt gsetkityss
     1261 ggqpvgtasl iplqsgsfal lqlpgqkpvp ssilqhvasl qmkresqnpd qkdetnsikr
     1321 eqetkkvlqs egeavdpean vikqnsgaat seetlndsle drgdhldeec lpeegcatvk
     1381 psehscitgs htdqdykdvn eeygarnrks skekvavlev rtisekasnk tvqnlskvqh
     1441 qklgdvkveq qkgfdnpeen ssefpvtfke eskfelsgsk vmeqqsnlqp eakekecgds
     1501 lekdrerwrk hlkgpltrkc vgasqeckke adeqliketk tcqensdvfq qeqgisdllg
     1561 ksgitedarv lktecdswsr isnpsafsiv prraakssrg nghfqghlll pgeqiqpkqe
     1621 kkggrssadf tvldleedde ddnektddsi deivdvvsdy qseevddvek nncveyiedd
     1681 eehvdietve elseeinvah lkttaahtqs fkqpscthis adekaaersr kappiplklk
     1741 pdywsdklqk eaeafayyrr thtanerrrr gemrdlfekl kitlgllhss kvsksliltr
     1801 afseiqgltd qadkligqkn lltrkrnili rkvsslsgkt eevvlkkley iyakqqalea
     1861 qkrkkkmgsd efdisprisk qqegssassv dlgqmfinnr rgkplilsrk kdqatentsp
     1921 lntphtsanl vmtpqgqllt lkgplfsgpv vavspdlles dlkpqvagsa valpenddlf
     1981 mmprivnvts lategglvdm ggskyphevp dskpsdhlkd tvrnednsle dkgrissrgn
     2041 rdgrvtlgpt qvflankdsg ypqivdvsnm qkaqeflpkk isgdmrgiqy kwkesesrge
     2101 rvkskdssfh klkmkdlkds siemelrkvt saieeaalds selltnmede ddtdetltsl
     2161 lneiaflnqq lnddsvglae lpssmdtefp gdarrafisk vppgsratfq vehlgtglke
     2221 lpdvqgesds isplllhled ddfsenekql aepasepdvl kividseikd sllsnkkaid
     2281 ggkntsglpa epesvssppt lhmktglens nstdtlwrpm pklaplglkv anpssdadgq
     2341 slkvmpclap iaakvgsvgh kmnltgndqe greskvmptl apvvaklgns gaspssagk
//
LOCUS       XP_047288264            2338 aa            linear   PRI 05-AUG-2025
DEFINITION  MAX gene-associated protein isoform X25 [Homo sapiens].
ACCESSION   XP_047288264
VERSION     XP_047288264.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432308.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2338
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2338
                     /product="MAX gene-associated protein isoform X25"
                     /calculated_mol_wt=257469
     Region          584..625
                     /region_name="MGA_dom"
                     /note="MGA, conserved domain; pfam16059"
                     /db_xref="CDD:464998"
     Region          1698..1762
                     /region_name="bHLHzip_MGA"
                     /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain
                     found in MAX gene-associated protein (MGA) and similar
                     proteins; cd18911"
                     /db_xref="CDD:381481"
     Site            order(1698,1700..1702,1704..1706,1708..1709,1713,
                     1732..1733)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381481"
     Site            order(1712,1715..1716,1718..1719,1722..1724,1734,
                     1737..1738,1741,1743..1745,1747..1748,1750..1751,1754,
                     1757..1758,1761..1762)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381481"
     CDS             1..2338
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /coded_by="XM_047432308.1:383..7399"
                     /db_xref="GeneID:23269"
                     /db_xref="HGNC:HGNC:14010"
                     /db_xref="MIM:616061"
ORIGIN      
        1 mfkldtgkmp vvylepcavt rstvkiselp dnmlstsrkd kssmlaeley lptyiensne
       61 tafclgkese nglrkhspdl rvvqkypllk epqwkypdis dsisterild dskdsvgdsl
      121 sgkedlgrkr ttmlkiataa kvvnanqnas pnvpgkrgrp rklklckagr ppkntgksli
      181 stkntpvspg stfpdvkpdl edvdgvlfvs feskealdih avdgtteess slqasttnds
      241 gyrarisqle keliedlktl rhkqvihpgl qevglklnsv dptmsidlky lgvqlplapa
      301 tsfpfwnltg tnpaspdagf pfvsrtgktn dftkikgwrg kfhsasasrn eggnsesslk
      361 nrsafcsdkl deylenegkl metsmgfssn aptspvvyql ptkstsyvrt ldsvlkkqst
      421 ispstsyslk phsvppvsrk aksqnrqatf sgrtkssyks ilpypvspkq kyshvilgdk
      481 vtknssgiis enqannfvvp tldenifpkq islrqaqqqq qqqqgsrppg lsksqvklmd
      541 ledcalwegk prtyiteera dvslttllta qaslktkpih tiirkrappc nndfcrlgcv
      601 csslalekrq pahcrrpdcm fgctclkrkv vlvkggsktk hfqrkaahrd pvfydtlgee
      661 areeeegire eeeqlkekkk rkkleytice tepeqpvrhy plwvkvegev dpepvyiptp
      721 sviepmkpll lpqpevlspt vkgklltgik sprsytpkpn pvireedkdp vylyfesmmt
      781 carvrvyerk kedqrqpsss sspspsfqqq tschsspenh nnakepdseq qplkqltcdl
      841 eddsdklqek swksscnege ssstsymhqr spggptklie iisdcnweed rnkilsilsq
      901 hinsnmpqsl kvngksypqa klllgqmgal hpanrlaayi tgrlrpsvld lstlstvisk
      961 vasnakvaas rkprtllpst snskmasssg tatnrpgknl kafvpakrpi enaaqipvat
     1021 pqvspntvkr agprlllipv qqgsptlrpv sntqlqghrm vlqpvrspsg mnlfrhpngq
     1081 ivqllplhql rgsntqpnlq pvmfrnpgsv mgirlpapsk psetppssts ssafsvmnpv
     1141 iqavgsssav nvitqapsll ssgasfvsqa gtltlrispp epqsfasktg setkityssg
     1201 gqpvgtasli plqsgsfall qlpgqkpvps silqhvaslq mkresqnpdq kdetnsikre
     1261 qetkkvlqse geavdpeanv ikqnsgaats eetlndsled rgdhldeecl peegcatvkp
     1321 sehscitgsh tdqdykdvne eygarnrkss kekvavlevr tisekasnkt vqnlskvqhq
     1381 klgdvkveqq kgfdnpeens sefpvtfkee skfelsgskv meqqsnlqpe akekecgdsl
     1441 ekdrerwrkh lkgpltrkcv gasqeckkea deqliketkt cqensdvfqq eqgisdllgk
     1501 sgitedarvl ktecdswsri snpsafsivp rraakssrgn ghfqghlllp geqiqpkqek
     1561 kggrssadft vldleedded dnektddsid eivdvvsdyq seevddvekn ncveyiedde
     1621 ehvdietvee lseeinvahl kttaahtqsf kqpscthisa dekaaersrk appiplklkp
     1681 dywsdklqke aeafayyrrt htanerrrrg emrdlfeklk itlgllhssk vsksliltra
     1741 fseiqgltdq adkligqknl ltrkrnilir kvsslsgkte evvlkkleyi yakqqaleaq
     1801 krkkkmgsde fdispriskq qegssassvd lgqmfinnrr gkplilsrkk dqatentspl
     1861 ntphtsanlv mtpqgqlltl kgplfsgpvv avspdllesd lkpqvagsav alpenddlfm
     1921 mprivnvtsl ategglvdmg gskyphevpd skpsdhlkdt vrnednsled kgrissrgnr
     1981 dgrvtlgptq vflankdsgy pqivdvsnmq kaqeflpkki sgdmrgiqyk wkesesrger
     2041 vkskdssfhk lkmkdlkdss iemelrkvts aieeaaldss elltnmeded dtdetltsll
     2101 neiaflnqql nddsvglael pssmdtefpg darrafiskv ppgsratfqv ehlgtglkel
     2161 pdvqgesdsi splllhledd dfsenekqla epasepdvlk ividseikds llsnkkaidg
     2221 gkntsglpae pesvsspptl hmktglensn stdtlwrpmp klaplglkva npssdadgqs
     2281 lkvmpclapi aakvgsvghk mnltgndqeg reskvmptla pvvaklgnsg aspssagk
//
LOCUS       XP_005254311            1627 aa            linear   PRI 05-AUG-2025
DEFINITION  MAX gene-associated protein isoform X26 [Homo sapiens].
ACCESSION   XP_005254311
VERSION     XP_005254311.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254254.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1627
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1627
                     /product="MAX gene-associated protein isoform X26"
                     /calculated_mol_wt=175744
     Region          48..>366
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          222..>544
                     /region_name="Atrophin-1"
                     /note="Atrophin-1 family; pfam03154"
                     /db_xref="CDD:460830"
     Region          987..1051
                     /region_name="bHLHzip_MGA"
                     /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain
                     found in MAX gene-associated protein (MGA) and similar
                     proteins; cd18911"
                     /db_xref="CDD:381481"
     Site            order(987,989..991,993..995,997..998,1002,1021..1022)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381481"
     Site            order(1001,1004..1005,1007..1008,1011..1013,1023,
                     1026..1027,1030,1032..1034,1036..1037,1039..1040,1043,
                     1046..1047,1050..1051)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381481"
     CDS             1..1627
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /coded_by="XM_005254254.5:101..4984"
                     /db_xref="GeneID:23269"
                     /db_xref="HGNC:HGNC:14010"
                     /db_xref="MIM:616061"
ORIGIN      
        1 meakvclfmq gfllqgslwp invnpvqvhl glsstviskv asnakvaasr kprtllpsts
       61 nskmasssgt atnrpgknlk afvpakrpia arpspggvft qfvmskvgal qqkipgvstp
      121 qtlagtqkfs irpspvmvvt pvvssepvqv cspvtaavtt ttpqvflent tavtpmtais
      181 dvetkettys sgatttgvve vsetntstsv tstqstatvn ltkttgittp vasvafpksl
      241 vaspstitlp vastastslv vvtaaasssm vttptsslgs vpiilsging sppvsqrpen
      301 aaqipvatpq vspntvkrag prlllipvqq gsptlrpvsn tqlqghrmvl qpvrspsgmn
      361 lfrhpngqiv qllplhqlrg sntqpnlqpv mfrnpgsvmg irlpapskps etppsstsss
      421 afsvmnpviq avgsssavnv itqapsllss gasfvsqagt ltlrisppep qsfasktgse
      481 tkityssggq pvgtaslipl qsgsfallql pgqkpvpssi lqhvaslqmk resqnpdqkd
      541 etnsikreqe tkkvlqsege avdpeanvik qnsgaatsee tlndsledrg dhldeeclpe
      601 egcatvkpse hscitgshtd qdykdvneey garnrksske kvavlevrti sekasnktvq
      661 nlskvqhqkl gdvkveqqkg fdnpeensse fpvtfkeesk felsgskvme qqsnlqpeak
      721 ekecgdslek drerwrkhlk gpltrkcvga sqeckkeade qliketktcq ensdvfqqeq
      781 gisdllgksg itedarvlkt ecdswsrisn psafsivprr aakssrgngh fqghlllpge
      841 qiqpkqekkg grssadftvl dleeddeddn ektddsidei vdvvsdyqse evddvekvnn
      901 cveyieddee hvdietveel seeinvahlk ttaahtqsfk qpscthisad ekaaersrka
      961 ppiplklkpd ywsdklqkea eafayyrrth tanerrrrge mrdlfeklki tlgllhsskv
     1021 sksliltraf seiqgltdqa dkligqknll trkrnilirk vsslsgktee vvlkkleyiy
     1081 akqqaleaqk rkkkmgsdef dispriskqq egssassvdl gqmfinnrrg kplilsrkkd
     1141 qatentspln tphtsanlvm tpqgqlltlk gplfsgpvva vspdllesdl kpqvagsava
     1201 lpenddlfmm privnvtsla tegglvdmgg skyphevpds kpsdhlkdtv rnednsledk
     1261 grissrgnrd grvtlgptqv flankdsgyp qivdvsnmqk aqeflpkkis gdmrgiqykw
     1321 kesesrgerv kskdssfhkl kmkdlkdssi emelrkvtsa ieeaaldsse lltnmededd
     1381 tdetltslln eiaflnqqln ddsvglaelp ssmdtefpgd arrafiskvp pgsratfqve
     1441 hlgtglkelp dvqgesdsis plllhleddd fsenekqlae pasepdvlki vidseikdsl
     1501 lsnkkaidgg kntsglpaep esvsspptlh mktglensns tdtlwrpmpk laplglkvan
     1561 pssdadgqsl kvmpclapia akvgsvghkm nltgndqegr eskvmptlap vvaklgnsga
     1621 spssagk
//
LOCUS       XP_011519701            1564 aa            linear   PRI 05-AUG-2025
DEFINITION  MAX gene-associated protein isoform X27 [Homo sapiens].
ACCESSION   XP_011519701
VERSION     XP_011519701.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521399.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1564
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1564
                     /product="MAX gene-associated protein isoform X27"
                     /calculated_mol_wt=169010
     Region          <52..>303
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          159..>481
                     /region_name="Atrophin-1"
                     /note="Atrophin-1 family; pfam03154"
                     /db_xref="CDD:460830"
     Region          924..988
                     /region_name="bHLHzip_MGA"
                     /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain
                     found in MAX gene-associated protein (MGA) and similar
                     proteins; cd18911"
                     /db_xref="CDD:381481"
     Site            order(924,926..928,930..932,934..935,939,958..959)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381481"
     Site            order(938,941..942,944..945,948..950,960,963..964,967,
                     969..971,973..974,976..977,980,983..984,987..988)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381481"
     CDS             1..1564
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /coded_by="XM_011521399.4:177..4871"
                     /db_xref="GeneID:23269"
                     /db_xref="HGNC:HGNC:14010"
                     /db_xref="MIM:616061"
ORIGIN      
        1 masssgtatn rpgknlkafv pakrpiaarp spggvftqfv mskvgalqqk ipgvstpqtl
       61 agtqkfsirp spvmvvtpvv ssepvqvcsp vtaavttttp qvflenttav tpmtaisdve
      121 tkettyssga tttgvvevse tntstsvtst qstatvnltk ttgittpvas vafpkslvas
      181 pstitlpvas tastslvvvt aaasssmvtt ptsslgsvpi ilsgingspp vsqrpenaaq
      241 ipvatpqvsp ntvkragprl llipvqqgsp tlrpvsntql qghrmvlqpv rspsgmnlfr
      301 hpngqivqll plhqlrgsnt qpnlqpvmfr npgsvmgirl papskpsetp psstsssafs
      361 vmnpviqavg sssavnvitq apsllssgas fvsqagtltl risppepqsf asktgsetki
      421 tyssggqpvg tasliplqsg sfallqlpgq kpvpssilqh vaslqmkres qnpdqkdetn
      481 sikreqetkk vlqsegeavd peanvikqns gaatseetln dsledrgdhl deeclpeegc
      541 atvkpsehsc itgshtdqdy kdvneeygar nrksskekva vlevrtisek asnktvqnls
      601 kvqhqklgdv kveqqkgfdn peenssefpv tfkeeskfel sgskvmeqqs nlqpeakeke
      661 cgdslekdre rwrkhlkgpl trkcvgasqe ckkeadeqli ketktcqens dvfqqeqgis
      721 dllgksgite darvlktecd swsrisnpsa fsivprraak ssrgnghfqg hlllpgeqiq
      781 pkqekkggrs sadftvldle eddeddnekt ddsideivdv vsdyqseevd dvekvnncve
      841 yieddeehvd ietveelsee invahlktta ahtqsfkqps cthisadeka aersrkappi
      901 plklkpdyws dklqkeaeaf ayyrrthtan errrrgemrd lfeklkitlg llhsskvsks
      961 liltrafsei qgltdqadkl igqknlltrk rnilirkvss lsgkteevvl kkleyiyakq
     1021 qaleaqkrkk kmgsdefdis priskqqegs sassvdlgqm finnrrgkpl ilsrkkdqat
     1081 entsplntph tsanlvmtpq gqlltlkgpl fsgpvvavsp dllesdlkpq vagsavalpe
     1141 nddlfmmpri vnvtslateg glvdmggsky phevpdskps dhlkdtvrne dnsledkgri
     1201 ssrgnrdgrv tlgptqvfla nkdsgypqiv dvsnmqkaqe flpkkisgdm rgiqykwkes
     1261 esrgervksk dssfhklkmk dlkdssieme lrkvtsaiee aaldssellt nmededdtde
     1321 tltsllneia flnqqlndds vglaelpssm dtefpgdarr afiskvppgs ratfqvehlg
     1381 tglkelpdvq gesdsispll lhledddfse nekqlaepas epdvlkivid seikdsllsn
     1441 kkaidggknt sglpaepesv sspptlhmkt glensnstdt lwrpmpklap lglkvanpss
     1501 dadgqslkvm pclapiaakv gsvghkmnlt gndqegresk vmptlapvva klgnsgasps
     1561 sagk
//
LOCUS       XP_047288265            1549 aa            linear   PRI 05-AUG-2025
DEFINITION  MAX gene-associated protein isoform X28 [Homo sapiens].
ACCESSION   XP_047288265
VERSION     XP_047288265.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432309.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1549
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1549
                     /product="MAX gene-associated protein isoform X28"
                     /calculated_mol_wt=172490
     Region          75..260
                     /region_name="T-box_MGA-like"
                     /note="DNA-binding domain of MAX gene-associated protein
                     and related T-box proteins; cd20195"
                     /db_xref="CDD:410321"
     Site            order(102..103,136,180,183,196..197,237..240,245,248..249,
                     252..258)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410321"
     Region          1041..1082
                     /region_name="MGA_dom"
                     /note="MGA, conserved domain; pfam16059"
                     /db_xref="CDD:464998"
     CDS             1..1549
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /coded_by="XM_047432309.1:189..4838"
                     /db_xref="GeneID:23269"
                     /db_xref="HGNC:HGNC:14010"
                     /db_xref="MIM:616061"
ORIGIN      
        1 meekqqiila nqdggtvaga aptffvilkq pgngktdqgi lvtnqdacal assvsspvks
       61 kgkiclpadc tvggitvtld nnsmwnefyh rstemiltkq grrmfpycry witgldsnlk
      121 yilvmdispv dnhrykwngr wwepsgkaep hvlgrvfihp espstghywm hqpvsfyklk
      181 ltnntldqeg hiilhsmhry lprlhlvpae kaveviqlng pgvhtftfpq teffavtayq
      241 niqitqlkid ynpfakgfrd dglnnkpqrd gkqknssdqe gnnissssgh rvrltegqgs
      301 eiqpgdldpl srghetsgkg lektslnikr dflgfmdtds alsevpqlkq eisecliass
      361 feddsrvasp ldqngsfnvv ikeeplddyd yelgecpegv tvkqeetdee tdvysnsddd
      421 pilekqlkrh nkvdnpeadh lsskwlpssp sgvakakmfk ldtgkmpvvy lepcavtrst
      481 vkiselpdnm lstsrkdkss mlaeleylpt yiensnetaf clgkesengl rkhspdlrvv
      541 qkypllkepq wkypdisdsi sterilddsk dsvgdslsgk edlgrkrttm lkiataakvv
      601 nanqnaspnv pgkrgrprkl klckagrppk ntgkslistk ntpvspgstf pdvkpdledv
      661 dgvlfvsfes kealdihavd gtteessslq asttndsgyr arisqlekel iedlktlrhk
      721 qvihpglqev glklnsvdpt msidlkylgv qlplapatsf pfwnltgtnp aspdagfpfv
      781 srtgktndft kikgwrgkfh sasasrnegg nsesslknrs afcsdkldey lenegklmet
      841 smgfssnapt spvvyqlptk stsyvrtlds vlkkqstisp stsyslkphs vppvsrkaks
      901 qnrqatfsgr tkssyksilp ypvspkqkys hvilgdkvtk nssgiisenq annfvvptld
      961 enifpkqisl rqaqqqqqqq qgsrppglsk sqvklmdled calwegkprt yiteeradvs
     1021 lttlltaqas lktkpihtii rkrappcnnd fcrlgcvcss lalekrqpah crrpdcmfgc
     1081 tclkrkvvlv kggsktkhfq rkaahrdpvf ydtlgeeare eeegireeee qlkekkkrkk
     1141 leyticetep eqpvrhyplw vkvegevdpe pvyiptpsvi epmkplllpq pevlsptvkg
     1201 klltgikspr sytpkpnpvi reedkdpvyl yfesmmtcar vrvyerkked qrqpsssssp
     1261 spsfqqqtsc hsspenhnna kepdseqqpl kqltcdledd sdklqekswk sscnegesss
     1321 tsymhqrspg gptklieiis dcnweedrnk ilsilsqhin snmpqslkvg sfiielasqr
     1381 ksrgeknppv yssrvkismp scqdqddmae ksgsetpdgp lspgkmedis pvqtdaldsv
     1441 rerlhggkgl pfyaglspag klvaykrkps sstsgliqyc hlqgsiqcqg gciqettypv
     1501 afniqfqngi llwhcnkspw eesegvcpsk tancgstlsw wcvhtvcde
//
LOCUS       XP_047288266            1533 aa            linear   PRI 05-AUG-2025
DEFINITION  MAX gene-associated protein isoform X29 [Homo sapiens].
ACCESSION   XP_047288266
VERSION     XP_047288266.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432310.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1533
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1533
                     /product="MAX gene-associated protein isoform X29"
                     /calculated_mol_wt=170682
     Region          75..260
                     /region_name="T-box_MGA-like"
                     /note="DNA-binding domain of MAX gene-associated protein
                     and related T-box proteins; cd20195"
                     /db_xref="CDD:410321"
     Site            order(102..103,136,180,183,196..197,237..240,245,248..249,
                     252..258)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410321"
     Region          1041..1082
                     /region_name="MGA_dom"
                     /note="MGA, conserved domain; pfam16059"
                     /db_xref="CDD:464998"
     CDS             1..1533
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /coded_by="XM_047432310.1:189..4790"
                     /db_xref="GeneID:23269"
                     /db_xref="HGNC:HGNC:14010"
                     /db_xref="MIM:616061"
ORIGIN      
        1 meekqqiila nqdggtvaga aptffvilkq pgngktdqgi lvtnqdacal assvsspvks
       61 kgkiclpadc tvggitvtld nnsmwnefyh rstemiltkq grrmfpycry witgldsnlk
      121 yilvmdispv dnhrykwngr wwepsgkaep hvlgrvfihp espstghywm hqpvsfyklk
      181 ltnntldqeg hiilhsmhry lprlhlvpae kaveviqlng pgvhtftfpq teffavtayq
      241 niqitqlkid ynpfakgfrd dglnnkpqrd gkqknssdqe gnnissssgh rvrltegqgs
      301 eiqpgdldpl srghetsgkg lektslnikr dflgfmdtds alsevpqlkq eisecliass
      361 feddsrvasp ldqngsfnvv ikeeplddyd yelgecpegv tvkqeetdee tdvysnsddd
      421 pilekqlkrh nkvdnpeadh lsskwlpssp sgvakakmfk ldtgkmpvvy lepcavtrst
      481 vkiselpdnm lstsrkdkss mlaeleylpt yiensnetaf clgkesengl rkhspdlrvv
      541 qkypllkepq wkypdisdsi sterilddsk dsvgdslsgk edlgrkrttm lkiataakvv
      601 nanqnaspnv pgkrgrprkl klckagrppk ntgkslistk ntpvspgstf pdvkpdledv
      661 dgvlfvsfes kealdihavd gtteessslq asttndsgyr arisqlekel iedlktlrhk
      721 qvihpglqev glklnsvdpt msidlkylgv qlplapatsf pfwnltgtnp aspdagfpfv
      781 srtgktndft kikgwrgkfh sasasrnegg nsesslknrs afcsdkldey lenegklmet
      841 smgfssnapt spvvyqlptk stsyvrtlds vlkkqstisp stsyslkphs vppvsrkaks
      901 qnrqatfsgr tkssyksilp ypvspkqkys hvilgdkvtk nssgiisenq annfvvptld
      961 enifpkqisl rqaqqqqqqq qgsrppglsk sqvklmdled calwegkprt yiteeradvs
     1021 lttlltaqas lktkpihtii rkrappcnnd fcrlgcvcss lalekrqpah crrpdcmfgc
     1081 tclkrkvvlv kggsktkhfq rkaahrdpvf ydtlgeeare eeegireeee qlkekkkrkk
     1141 leyticetep eqpvrhyplw vkvegevdpe pvyiptpsvi epmkplllpq pevlsptvkg
     1201 klltgikspr sytpkpnpvi reedkdpvyl yfesmmtcar vrvyerkked qrqpsssssp
     1261 spsfqqqtsc hsspenhnna kepdseqqpl kqltcdledd sdklqekswk sscnegesss
     1321 tsymhqrspg gptklieiis dcnweedrnk ilsilsqhin snmpqslkvg sfiielasqr
     1381 ksrgeknppv yssrvkismp scqdqddmae ksgsetpdgp lspgkmedis pvqtdaldsv
     1441 rerlhggkgl pfyaglspag klvaykrkps sstsgliqyc hlqgsiqcqg gciqettypv
     1501 afniqfqngi llwhcnkspw eesegvcpsk tan
//
LOCUS       XP_047288267            1516 aa            linear   PRI 05-AUG-2025
DEFINITION  MAX gene-associated protein isoform X30 [Homo sapiens].
ACCESSION   XP_047288267
VERSION     XP_047288267.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432311.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1516
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1516
                     /product="MAX gene-associated protein isoform X30"
                     /calculated_mol_wt=168913
     Region          75..260
                     /region_name="T-box_MGA-like"
                     /note="DNA-binding domain of MAX gene-associated protein
                     and related T-box proteins; cd20195"
                     /db_xref="CDD:410321"
     Site            order(102..103,136,180,183,196..197,237..240,245,248..249,
                     252..258)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410321"
     Region          1041..1082
                     /region_name="MGA_dom"
                     /note="MGA, conserved domain; pfam16059"
                     /db_xref="CDD:464998"
     CDS             1..1516
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /coded_by="XM_047432311.1:189..4739"
                     /db_xref="GeneID:23269"
                     /db_xref="HGNC:HGNC:14010"
                     /db_xref="MIM:616061"
ORIGIN      
        1 meekqqiila nqdggtvaga aptffvilkq pgngktdqgi lvtnqdacal assvsspvks
       61 kgkiclpadc tvggitvtld nnsmwnefyh rstemiltkq grrmfpycry witgldsnlk
      121 yilvmdispv dnhrykwngr wwepsgkaep hvlgrvfihp espstghywm hqpvsfyklk
      181 ltnntldqeg hiilhsmhry lprlhlvpae kaveviqlng pgvhtftfpq teffavtayq
      241 niqitqlkid ynpfakgfrd dglnnkpqrd gkqknssdqe gnnissssgh rvrltegqgs
      301 eiqpgdldpl srghetsgkg lektslnikr dflgfmdtds alsevpqlkq eisecliass
      361 feddsrvasp ldqngsfnvv ikeeplddyd yelgecpegv tvkqeetdee tdvysnsddd
      421 pilekqlkrh nkvdnpeadh lsskwlpssp sgvakakmfk ldtgkmpvvy lepcavtrst
      481 vkiselpdnm lstsrkdkss mlaeleylpt yiensnetaf clgkesengl rkhspdlrvv
      541 qkypllkepq wkypdisdsi sterilddsk dsvgdslsgk edlgrkrttm lkiataakvv
      601 nanqnaspnv pgkrgrprkl klckagrppk ntgkslistk ntpvspgstf pdvkpdledv
      661 dgvlfvsfes kealdihavd gtteessslq asttndsgyr arisqlekel iedlktlrhk
      721 qvihpglqev glklnsvdpt msidlkylgv qlplapatsf pfwnltgtnp aspdagfpfv
      781 srtgktndft kikgwrgkfh sasasrnegg nsesslknrs afcsdkldey lenegklmet
      841 smgfssnapt spvvyqlptk stsyvrtlds vlkkqstisp stsyslkphs vppvsrkaks
      901 qnrqatfsgr tkssyksilp ypvspkqkys hvilgdkvtk nssgiisenq annfvvptld
      961 enifpkqisl rqaqqqqqqq qgsrppglsk sqvklmdled calwegkprt yiteeradvs
     1021 lttlltaqas lktkpihtii rkrappcnnd fcrlgcvcss lalekrqpah crrpdcmfgc
     1081 tclkrkvvlv kggsktkhfq rkaahrdpvf ydtlgeeare eeegireeee qlkekkkrkk
     1141 leyticetep eqpvrhyplw vkvegevdpe pvyiptpsvi epmkplllpq pevlsptvkg
     1201 klltgikspr sytpkpnpvi reedkdpvyl yfesmmtcar vrvyerkked qrqpsssssp
     1261 spsfqqqtsc hsspenhnna kepdseqqpl kqltcdledd sdklqekswk sscnegesss
     1321 tsymhqrspg gptklieiis dcnweedrnk ilsilsqhin snmpqslkvg sfiielasqr
     1381 ksrgeknppv yssrvkismp scqdqddmae ksgsetpdgp lspgkmedis pvqtdaldsv
     1441 rerlhggkgl pfyaglspag klvaykrkps sstsgliqhp mprwlhpgnh vpcclqhpip
     1501 kwhpplalqq ialgri
//
LOCUS       XP_047288268            1516 aa            linear   PRI 05-AUG-2025
DEFINITION  MAX gene-associated protein isoform X30 [Homo sapiens].
ACCESSION   XP_047288268
VERSION     XP_047288268.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432312.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1516
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1516
                     /product="MAX gene-associated protein isoform X30"
                     /calculated_mol_wt=168913
     Region          75..260
                     /region_name="T-box_MGA-like"
                     /note="DNA-binding domain of MAX gene-associated protein
                     and related T-box proteins; cd20195"
                     /db_xref="CDD:410321"
     Site            order(102..103,136,180,183,196..197,237..240,245,248..249,
                     252..258)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410321"
     Region          1041..1082
                     /region_name="MGA_dom"
                     /note="MGA, conserved domain; pfam16059"
                     /db_xref="CDD:464998"
     CDS             1..1516
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /coded_by="XM_047432312.1:189..4739"
                     /db_xref="GeneID:23269"
                     /db_xref="HGNC:HGNC:14010"
                     /db_xref="MIM:616061"
ORIGIN      
        1 meekqqiila nqdggtvaga aptffvilkq pgngktdqgi lvtnqdacal assvsspvks
       61 kgkiclpadc tvggitvtld nnsmwnefyh rstemiltkq grrmfpycry witgldsnlk
      121 yilvmdispv dnhrykwngr wwepsgkaep hvlgrvfihp espstghywm hqpvsfyklk
      181 ltnntldqeg hiilhsmhry lprlhlvpae kaveviqlng pgvhtftfpq teffavtayq
      241 niqitqlkid ynpfakgfrd dglnnkpqrd gkqknssdqe gnnissssgh rvrltegqgs
      301 eiqpgdldpl srghetsgkg lektslnikr dflgfmdtds alsevpqlkq eisecliass
      361 feddsrvasp ldqngsfnvv ikeeplddyd yelgecpegv tvkqeetdee tdvysnsddd
      421 pilekqlkrh nkvdnpeadh lsskwlpssp sgvakakmfk ldtgkmpvvy lepcavtrst
      481 vkiselpdnm lstsrkdkss mlaeleylpt yiensnetaf clgkesengl rkhspdlrvv
      541 qkypllkepq wkypdisdsi sterilddsk dsvgdslsgk edlgrkrttm lkiataakvv
      601 nanqnaspnv pgkrgrprkl klckagrppk ntgkslistk ntpvspgstf pdvkpdledv
      661 dgvlfvsfes kealdihavd gtteessslq asttndsgyr arisqlekel iedlktlrhk
      721 qvihpglqev glklnsvdpt msidlkylgv qlplapatsf pfwnltgtnp aspdagfpfv
      781 srtgktndft kikgwrgkfh sasasrnegg nsesslknrs afcsdkldey lenegklmet
      841 smgfssnapt spvvyqlptk stsyvrtlds vlkkqstisp stsyslkphs vppvsrkaks
      901 qnrqatfsgr tkssyksilp ypvspkqkys hvilgdkvtk nssgiisenq annfvvptld
      961 enifpkqisl rqaqqqqqqq qgsrppglsk sqvklmdled calwegkprt yiteeradvs
     1021 lttlltaqas lktkpihtii rkrappcnnd fcrlgcvcss lalekrqpah crrpdcmfgc
     1081 tclkrkvvlv kggsktkhfq rkaahrdpvf ydtlgeeare eeegireeee qlkekkkrkk
     1141 leyticetep eqpvrhyplw vkvegevdpe pvyiptpsvi epmkplllpq pevlsptvkg
     1201 klltgikspr sytpkpnpvi reedkdpvyl yfesmmtcar vrvyerkked qrqpsssssp
     1261 spsfqqqtsc hsspenhnna kepdseqqpl kqltcdledd sdklqekswk sscnegesss
     1321 tsymhqrspg gptklieiis dcnweedrnk ilsilsqhin snmpqslkvg sfiielasqr
     1381 ksrgeknppv yssrvkismp scqdqddmae ksgsetpdgp lspgkmedis pvqtdaldsv
     1441 rerlhggkgl pfyaglspag klvaykrkps sstsgliqhp mprwlhpgnh vpcclqhpip
     1501 kwhpplalqq ialgri
//
LOCUS       XP_047288269            1406 aa            linear   PRI 05-AUG-2025
DEFINITION  MAX gene-associated protein isoform X31 [Homo sapiens].
ACCESSION   XP_047288269
VERSION     XP_047288269.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432313.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1406
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1406
                     /product="MAX gene-associated protein isoform X31"
                     /calculated_mol_wt=157194
     Region          75..260
                     /region_name="T-box_MGA-like"
                     /note="DNA-binding domain of MAX gene-associated protein
                     and related T-box proteins; cd20195"
                     /db_xref="CDD:410321"
     Site            order(102..103,136,180,183,196..197,237..240,245,248..249,
                     252..258)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410321"
     Region          1041..1082
                     /region_name="MGA_dom"
                     /note="MGA, conserved domain; pfam16059"
                     /db_xref="CDD:464998"
     CDS             1..1406
                     /gene="MGA"
                     /gene_synonym="MAD5; MXD5; POF26"
                     /coded_by="XM_047432313.1:189..4409"
                     /db_xref="GeneID:23269"
                     /db_xref="HGNC:HGNC:14010"
                     /db_xref="MIM:616061"
ORIGIN      
        1 meekqqiila nqdggtvaga aptffvilkq pgngktdqgi lvtnqdacal assvsspvks
       61 kgkiclpadc tvggitvtld nnsmwnefyh rstemiltkq grrmfpycry witgldsnlk
      121 yilvmdispv dnhrykwngr wwepsgkaep hvlgrvfihp espstghywm hqpvsfyklk
      181 ltnntldqeg hiilhsmhry lprlhlvpae kaveviqlng pgvhtftfpq teffavtayq
      241 niqitqlkid ynpfakgfrd dglnnkpqrd gkqknssdqe gnnissssgh rvrltegqgs
      301 eiqpgdldpl srghetsgkg lektslnikr dflgfmdtds alsevpqlkq eisecliass
      361 feddsrvasp ldqngsfnvv ikeeplddyd yelgecpegv tvkqeetdee tdvysnsddd
      421 pilekqlkrh nkvdnpeadh lsskwlpssp sgvakakmfk ldtgkmpvvy lepcavtrst
      481 vkiselpdnm lstsrkdkss mlaeleylpt yiensnetaf clgkesengl rkhspdlrvv
      541 qkypllkepq wkypdisdsi sterilddsk dsvgdslsgk edlgrkrttm lkiataakvv
      601 nanqnaspnv pgkrgrprkl klckagrppk ntgkslistk ntpvspgstf pdvkpdledv
      661 dgvlfvsfes kealdihavd gtteessslq asttndsgyr arisqlekel iedlktlrhk
      721 qvihpglqev glklnsvdpt msidlkylgv qlplapatsf pfwnltgtnp aspdagfpfv
      781 srtgktndft kikgwrgkfh sasasrnegg nsesslknrs afcsdkldey lenegklmet
      841 smgfssnapt spvvyqlptk stsyvrtlds vlkkqstisp stsyslkphs vppvsrkaks
      901 qnrqatfsgr tkssyksilp ypvspkqkys hvilgdkvtk nssgiisenq annfvvptld
      961 enifpkqisl rqaqqqqqqq qgsrppglsk sqvklmdled calwegkprt yiteeradvs
     1021 lttlltaqas lktkpihtii rkrappcnnd fcrlgcvcss lalekrqpah crrpdcmfgc
     1081 tclkrkvvlv kggsktkhfq rkaahrdpvf ydtlgeeare eeegireeee qlkekkkrkk
     1141 leyticetep eqpvrhyplw vkvegevdpe pvyiptpsvi epmkplllpq pevlsptvkg
     1201 klltgikspr sytpkpnpvi reedkdpvyl yfesmmtcar vrvyerkked qrqpsssssp
     1261 spsfqqqtsc hsspenhnna kepdseqqpl kqltcdledd sdklqekswk sscnegesss
     1321 tsymhqrspg gptklieiis dcnweedrnk ilsilsqhin snmpqslkhp mprwlhpgnh
     1381 vpcclqhpip kwhpplalqq ialgri
//
LOCUS       XP_047288270            2923 aa            linear   PRI 05-AUG-2025
DEFINITION  dmX-like protein 2 isoform X1 [Homo sapiens].
ACCESSION   XP_047288270
VERSION     XP_047288270.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432314.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2923
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2923
                     /product="dmX-like protein 2 isoform X1"
                     /calculated_mol_wt=326929
     Region          <45..268
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          61..102
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          109..171
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          174..225
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          235..268
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1171..1902
                     /region_name="Rav1p_C"
                     /note="RAVE protein 1 C terminal; pfam12234"
                     /db_xref="CDD:432413"
     CDS             1..2923
                     /gene="DMXL2"
                     /gene_synonym="DEE81; DFNA71; EIEE81; PEPNS; RC3"
                     /coded_by="XM_047432314.1:227..8998"
                     /db_xref="GeneID:23312"
                     /db_xref="HGNC:HGNC:2938"
                     /db_xref="MIM:612186"
ORIGIN      
        1 mhlhqvltga vnpgdncysv gsvgdvpfta ygsgcdivil andfecvqii pgakhgniqv
       61 scvecsnqqg riaasygnav cifeplgins hkrncqlkcq wlktgqffls svtynlawdp
      121 qdnrlltatd siqlwappgd dileeeeeid ntvppvlndw kcvwqcktsv svhlmewspd
      181 geyfatagkd dcllkvwypm tgwkssiipq dhhevkrrqs stqfsfvyla hpravtgfsw
      241 rktskymprg svcnvlltsc hdgvcrlwae tllpedcllg eqicetttss iasslshagr
      301 hkdriqhale tihhlknlrk gqrrssvlvt haelmpdqta mhevqrhish hanalchfhi
      361 aasinpatdi pnvlvgtafn vddgnggfvv hwlnnkefhf tsstevfmhq lrklsdkqvd
      421 henddadred eehsqedrer glhmkldhdl sldreseagt gssehedger egsprtysrl
      481 svpmplptvl ldrkietllt ewnknpdmlf tihpvdgtfl vwhvkyldey npgifrqvqv
      541 sfssripvaf psgdasslsk nimmyacina tkdshhtllh qegmsvgsph gsqphsrshs
      601 thmnilaptv mmiskhidgs lnqwavtfad ksafttvltv shkfrycghr fhlndlachs
      661 vlpllltssh hnalltpeld cqwdsdnkls rlmdpvkhik gsskqplrna atrtfhdpna
      721 iyselilwrv dpigplsytg gvselarins lhtsafsnva wlptlipsyc lgtycnsasa
      781 cfvasdgknl rlyqavvdar klldelsdpe sskligevfn ivsqqstarp gciieldait
      841 nqcgsntqll hvfqedfiig ykphkedmek keteiffqps qgyrpppfse kfflvviekd
      901 snnnsilhmw hlhlksvqac lakasegass esllsvpgqk nvdsspetsp svspmphsss
      961 ianlqtaskl ilssrlvysq pldlpesvev iratpsaghl ssssiypvcl apylvvttcs
     1021 dnkvrfwkcc meanpecnks dekeiyhwkr wplmndeged nsstvsivgr pvavscsytg
     1081 rlavaykqpi hhngfvskef smhvcifece stggsewvle qtihlddlvk vgsvldsrvs
     1141 vdsnlfvysk sdallskdry lipnikhlvh ldwvskedgs hiltvgvgan ifmygrlsgi
     1201 vteqtnskdg vavitlplgg sikqgvksrw vllrsidlvs svdgtpslpv slswvrdgil
     1261 vvgmdcemhv yaqwkhavkf gdteadssna eeaamqdhst fksnmlarks vvegtaisdd
     1321 vfcsptviqd gglfeaahvl sptlpqyhpt qllelmdlgk vrrakailsh lvkciageva
     1381 ivrdpdageg tkrhlsrtis vsgstaketv tvgkdgtrdy teidsipplp lyallaadqd
     1441 tsyriseest kipqsyedqt vsqpedqyse lfqiqdiptd didlepekre nkskvinlsq
     1501 ygpayfgqeh arvlsshlmh sslpgltrle qmflvaladt vattstelde srdkscsgrd
     1561 tldecglryl lamrlhtcll tslpplyrvq llhqgvstch fawafhseae eelinmipai
     1621 qrgdpqwsel ramgigwwvr nintlrrcie kvakasfqrn ndaldaalfy lsmkkkavvw
     1681 glfrsqhdek mttffshnfn edrwrkaalk nafsllgkqr feqsaaffll agslkdaiev
     1741 clekmediql amviarlyes efetsstyis ilnqkilgcq kdgsgfsckr lhpdpflrsl
     1801 aywvmkdytr aldtlleqtp keddehqvii kscnpvafsf ynylrthpll irrnlaspeg
     1861 tlatlglkte knfvdkinli erklffttan ahfkvgcpvl alevlskipk vtktsalsak
     1921 kdqpdfishr mddvpshska lsdgngssgi ewsnvtssqy dwsqpivkvd eeplnldwge
     1981 dhdsaldeee ddavglvmks tdarekdkqs dqkasdpnml ltpqeeddpe gdtevdviae
     2041 qlkfraclki lmtelrtlat gyevdggklr fqlynwleke iaalheicnh esvikeyssk
     2101 tyskvesdll dqeemvdkpd igsyerhqie rrrlqakreh aerrkswlqk nqdllrvfls
     2161 ycslhgaqgg glasvrmelk fllqesqqet tvkqlqsplp lpttlpllsa siastktvia
     2221 npvlylnnhi hdilytivqm ktpphpsied vkvhtlhsla aslsasiyqa lcdshsyssq
     2281 tegnqftgma yqglllsdrr rlrtesieeh atpnsspaqw pgvsslinll ssaqdedqpk
     2341 lnillceavv avylslliha latnssself rlaahplnnr mwaavfgggv klvvkprrqs
     2401 enisappvls edidkhrrrf nmrmlvpgrp vkdatpppvp aerpsykekf ippelsmwdy
     2461 fvakpflpls dsgviydsde sihsdeedda ffsdtqiqeh qdpnsyswal lhltmvklal
     2521 hnvknffpia glefselpvt splgiavikn lenweqilqe kmdqfegppp nyintyptdl
     2581 svgagpailr nkamlepent pfksrdssaf pvkrlwhflv kqevlqetfi ryiftkkrkq
     2641 sesieehveq vnqnciaedc hikveadlgy pggkakvihk esdmimafsv nkancneivl
     2701 asthdvqeld vtsllacqsy iwigeeydre skssddvdyr gstttlyqps atsysasqvh
     2761 ppsslpwlgt gqtstgasvl mkrnlhnvkr mtshpvhqyy ltgaqdgsvr mfewtrpqql
     2821 vcfrqagnar vtrlyfnsqg nkcgvadgeg flsiwqvnqt asnpkpymsw qchskatsdf
     2881 afitssslva tsghsndnrf hvprswchgt avctqtatpn lgg
//
LOCUS       XP_047288271            2888 aa            linear   PRI 05-AUG-2025
DEFINITION  dmX-like protein 2 isoform X2 [Homo sapiens].
ACCESSION   XP_047288271
VERSION     XP_047288271.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432315.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2888
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2888
                     /product="dmX-like protein 2 isoform X2"
                     /calculated_mol_wt=323315
     Region          <45..268
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          61..102
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          109..171
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          174..225
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          235..268
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1171..1902
                     /region_name="Rav1p_C"
                     /note="RAVE protein 1 C terminal; pfam12234"
                     /db_xref="CDD:432413"
     CDS             1..2888
                     /gene="DMXL2"
                     /gene_synonym="DEE81; DFNA71; EIEE81; PEPNS; RC3"
                     /coded_by="XM_047432315.1:227..8893"
                     /db_xref="GeneID:23312"
                     /db_xref="HGNC:HGNC:2938"
                     /db_xref="MIM:612186"
ORIGIN      
        1 mhlhqvltga vnpgdncysv gsvgdvpfta ygsgcdivil andfecvqii pgakhgniqv
       61 scvecsnqqg riaasygnav cifeplgins hkrncqlkcq wlktgqffls svtynlawdp
      121 qdnrlltatd siqlwappgd dileeeeeid ntvppvlndw kcvwqcktsv svhlmewspd
      181 geyfatagkd dcllkvwypm tgwkssiipq dhhevkrrqs stqfsfvyla hpravtgfsw
      241 rktskymprg svcnvlltsc hdgvcrlwae tllpedcllg eqicetttss iasslshagr
      301 hkdriqhale tihhlknlrk gqrrssvlvt haelmpdqta mhevqrhish hanalchfhi
      361 aasinpatdi pnvlvgtafn vddgnggfvv hwlnnkefhf tsstevfmhq lrklsdkqvd
      421 henddadred eehsqedrer glhmkldhdl sldreseagt gssehedger egsprtysrl
      481 svpmplptvl ldrkietllt ewnknpdmlf tihpvdgtfl vwhvkyldey npgifrqvqv
      541 sfssripvaf psgdasslsk nimmyacina tkdshhtllh qegmsvgsph gsqphsrshs
      601 thmnilaptv mmiskhidgs lnqwavtfad ksafttvltv shkfrycghr fhlndlachs
      661 vlpllltssh hnalltpeld cqwdsdnkls rlmdpvkhik gsskqplrna atrtfhdpna
      721 iyselilwrv dpigplsytg gvselarins lhtsafsnva wlptlipsyc lgtycnsasa
      781 cfvasdgknl rlyqavvdar klldelsdpe sskligevfn ivsqqstarp gciieldait
      841 nqcgsntqll hvfqedfiig ykphkedmek keteiffqps qgyrpppfse kfflvviekd
      901 snnnsilhmw hlhlksvqac lakasegass esllsvpgqk nvdsspetsp svspmphsss
      961 ianlqtaskl ilssrlvysq pldlpesvev iratpsaghl ssssiypvcl apylvvttcs
     1021 dnkvrfwkcc meanpecnks dekeiyhwkr wplmndeged nsstvsivgr pvavscsytg
     1081 rlavaykqpi hhngfvskef smhvcifece stggsewvle qtihlddlvk vgsvldsrvs
     1141 vdsnlfvysk sdallskdry lipnikhlvh ldwvskedgs hiltvgvgan ifmygrlsgi
     1201 vteqtnskdg vavitlplgg sikqgvksrw vllrsidlvs svdgtpslpv slswvrdgil
     1261 vvgmdcemhv yaqwkhavkf gdteadssna eeaamqdhst fksnmlarks vvegtaisdd
     1321 vfcsptviqd gglfeaahvl sptlpqyhpt qllelmdlgk vrrakailsh lvkciageva
     1381 ivrdpdageg tkrhlsrtis vsgstaketv tvgkdgtrdy teidsipplp lyallaadqd
     1441 tsyriseest kipqsyedqt vsqpedqyse lfqiqdiptd didlepekre nkskvinlsq
     1501 ygpayfgqeh arvlsshlmh sslpgltrle qmflvaladt vattstelde srdkscsgrd
     1561 tldecglryl lamrlhtcll tslpplyrvq llhqgvstch fawafhseae eelinmipai
     1621 qrgdpqwsel ramgigwwvr nintlrrcie kvakasfqrn ndaldaalfy lsmkkkavvw
     1681 glfrsqhdek mttffshnfn edrwrkaalk nafsllgkqr feqsaaffll agslkdaiev
     1741 clekmediql amviarlyes efetsstyis ilnqkilgcq kdgsgfsckr lhpdpflrsl
     1801 aywvmkdytr aldtlleqtp keddehqvii kscnpvafsf ynylrthpll irrnlaspeg
     1861 tlatlglkte knfvdkinli erklffttan ahfkvgcpvl alevlskipk vtktsalsak
     1921 kdqpdfishr mddvpshska lsdgngssgi ewsnvtssqy dwsqpivkvd eeplnldwge
     1981 dhdsaldeee ddavglvmks tdarekdkqs dqkasdpnml ltpqeeddpe gdtevdviae
     2041 qlkfraclki lmtelrtlat gyevdggklr fqlynwleke iaalheicnh esvikeyssk
     2101 tyskvesdll dqeemvdkpd igsyerhqie rrrlqakreh aerrkswlqk nqdllrvfls
     2161 ycslhgaqgg glasvrmelk fllqesqqet tvkqlqsplp lpttlpllsa siastktvia
     2221 npvlylnnhi hdilytivqm ktpphpsied vkvhtlhsla aslsasiyqa lcdshsyssq
     2281 tegnqftgma yqglllsdrr rlrtesieeh atpnsspaqw pgvsslinll ssaqdedqpk
     2341 lnillceavv avylslliha latnssself rlaahplnnr mwaavfgggv klvvkprrqs
     2401 enisappvls edidkhrrrf nmrmlvpgrp vkdatpppvp aerpsykekf ippelsmwdy
     2461 fvakpflpls dsgviydsde sihsdeedda ffsdtqiqeh qdpnsyswal lhltmvklal
     2521 hnvknffpia glefselpvt splgiavikn lenweqilqe kmdqfegppp nyintyptdl
     2581 svgagpailr nkamlepent pfksrdssaf pvkrlwhflv kqevlqetfi ryiftkkrkq
     2641 sesieehveq vnqnciaedc hikveadlgy pggkakvihk esdmimafsv nkancneivl
     2701 asthdvqeld vtsllacqsy iwigeeydre skssddvdyr gstttlyqps atsysasqvh
     2761 ppsslpwlgt gqtstgasvl mkrnlhnvkr mtshpvhqyy ltgaqdgsvr mfewtrpqql
     2821 vcfrqagnar vtrlyfnsqg nkcgvadgeg flsiwqvnqt asnpkpymvs ratimvpryc
     2881 smhpnsns
//
LOCUS       XP_047288272            2884 aa            linear   PRI 05-AUG-2025
DEFINITION  dmX-like protein 2 isoform X3 [Homo sapiens].
ACCESSION   XP_047288272
VERSION     XP_047288272.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432316.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2884
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2884
                     /product="dmX-like protein 2 isoform X3"
                     /calculated_mol_wt=322941
     Region          997..1728
                     /region_name="Rav1p_C"
                     /note="RAVE protein 1 C terminal; pfam12234"
                     /db_xref="CDD:432413"
     Region          2614..2866
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          2658..2698
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2703..2745
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2752..2787
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2793..2829
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..2884
                     /gene="DMXL2"
                     /gene_synonym="DEE81; DFNA71; EIEE81; PEPNS; RC3"
                     /coded_by="XM_047432316.1:474..9128"
                     /db_xref="GeneID:23312"
                     /db_xref="HGNC:HGNC:2938"
                     /db_xref="MIM:612186"
ORIGIN      
        1 mewspdgeyf atagkddcll kvwypmtgwk ssiipqdhhe vkrrqsstqf sfvylahpra
       61 vtgfswrkts kymprgsvcn vlltschdgv crlwaetllp edcllgeqic etttssiass
      121 lshagrhkdr iqhaletihh lknlrkgqrr ssvlvthael mpdqtamhev qrhishhana
      181 lchfhiaasi npatdipnvl vgtafnvddg nggfvvhwln nkefhftsst evfmhqlrkl
      241 sdkqvdhend dadredeehs qedrerglhm kldhdlsldr eseagtgsse hedgeregsp
      301 rtysrlsvpm plptvlldrk ietlltewnk npdmlftihp vdgtflvwhv kyldeynpgi
      361 frqvqvsfss ripvafpsgd asslsknimm yacinatkds hhtllhqegm svgsphgsqp
      421 hsrshsthmn ilaptvmmis khidgslnqw avtfadksaf ttvltvshkf rycghrfhln
      481 dlachsvlpl lltsshhnal ltpeldcqwd sdnklsrlmd pvkhikgssk qplrnaatrt
      541 fhdpnaiyse lilwrvdpig plsytggvse larinslhts afsnvawlpt lipsyclgty
      601 cnsasacfva sdgknlrlyq avvdarklld elsdpesskl igevfnivsq qstarpgcii
      661 eldaitnqcg sntqllhvfq edfiigykph kedmekkete iffqpsqgyr pppfsekffl
      721 vviekdsnnn silhmwhlhl ksvqaclaka segassesll svpgqknvds spetspsvsp
      781 mphsssianl qtasklilss rlvysqpldl pesvevirat psaghlssss iypvclapyl
      841 vvttcsdnkv rfwkccmean pecnksdeke iyhwkrwplm ndegednsst vsivgrpvav
      901 scsytgrlav aykqpihhng fvskefsmhv cifecestgg sewvleqtih lddlvkvgsv
      961 ldsrvsvdsn lfvysksdal lskdrylipn ikhlvhldwv skedgshilt vgvganifmy
     1021 grlsgivteq tnskdgvavi tlplggsikq gvksrwvllr sidlvssvdg tpslpvslsw
     1081 vrdgilvvgm dcemhvyaqw khavkfgdte adssnaeeaa mqdhstfksn mlarksvveg
     1141 taisddvfcs ptviqdgglf eaahvlsptl pqyhptqlle lmdlgkvrra kailshlvkc
     1201 iagevaivrd pdagegtkrh lsrtisvsgs taketvtvgk dgtrdyteid sipplplyal
     1261 laadqdtsyr iseestkipq syedqtvsqp edqyselfqi qdiptddidl epekrenksk
     1321 vinlsqygpa yfgqeharvl sshlmhsslp gltrleqmfl valadtvatt steldesrdk
     1381 scsgrdtlde cglryllamr lhtclltslp plyrvqllhq gvstchfawa fhseaeeeli
     1441 nmipaiqrgd pqwselramg igwwvrnint lrrciekvak asfqrnndal daalfylsmk
     1501 kkavvwglfr sqhdekmttf fshnfnedrw rkaalknafs llgkqrfeqs aaffllagsl
     1561 kdaievclek mediqlamvi arlyesefet sstyisilnq kilgcqkdgs gfsckrlhpd
     1621 pflrslaywv mkdytraldt lleqtpkedd ehqviikscn pvafsfynyl rthpllirrn
     1681 laspegtlat lglkteknfv dkinlierkl ffttanahfk vgcpvlalev lskipkvtkt
     1741 salsakkdqp dfishrmddv pshskalsdg ngssgiewsn vtssqydwsq pivkvdeepl
     1801 nldwgedhds aldeeeddav glvmkstdar ekdkqsdqka sdpnmlltpq eeddpegdte
     1861 vdviaeqlkf raclkilmte lrtlatgyev dggklrfqly nwlekeiaal heicnhesvi
     1921 keyssktysk vesdlldqee mvdkpdigsy erhqierrrl qakrehaerr kswlqknqdl
     1981 lrvflsycsl hgaqggglas vrmelkfllq esqqettvkq lqsplplptt lpllsasias
     2041 tktvianpvl ylnnhihdil ytivqmktpp hpsiedvkvh tlhslaasls asiyqalcds
     2101 hsyssqtegn qftgmayqgl llsdrrrlrt esieehatpn sspaqwpgvs slinllssaq
     2161 dedqpklnil lceavvavyl sllihalatn ssselfrlaa hplnnrmwaa vfgggvklvv
     2221 kprrqsenis appvlsedid khrrrfnmrm lvpgrpvkda tpppvpaerp sykekfippe
     2281 lsmwdyfvak pflplsdsgv iydsdesihs deeddaffsd tqiqehqdpn syswallhlt
     2341 mvklalhnvk nffpiaglef selpvtsplg iaviknlenw eqilqekmdq fegpppnyin
     2401 typtdlsvga gpailrnkam lepentpfks rdssafpvkr lwhflvkqev lqetfiryif
     2461 tkkrkqsesi eehveqvnqn ciaedchikv eadlgypggk akvihkesdm imafsvnkan
     2521 cneivlasth dvqeldvtsl lacqsyiwig eeydreskss ddvdyrgstt tlyqpsatsy
     2581 sasqvhppss lpwlgtgqts tgasvlmkrn lhnvkrmtsh pvhqyyltga qdgsvrmfew
     2641 trpqqlvcfr qagnarvtrl yfnsqgnkcg vadgegflsi wqvnqtasnp kpymswqchs
     2701 katsdfafit ssslvatsgh sndnrnvclw dtlispgnsl ihgftchdhg atvlqyapkq
     2761 qllisggrkg hvcifdirqr qlihtfqahd saikalaldp yeeyfttgsa egnikvwrlt
     2821 ghglihsfks ehakqsifrn igagvmqidi iqgnrlfscg adgtlktrvl pnafnipnri
     2881 ldil
//
LOCUS       XP_047288273            2884 aa            linear   PRI 05-AUG-2025
DEFINITION  dmX-like protein 2 isoform X3 [Homo sapiens].
ACCESSION   XP_047288273
VERSION     XP_047288273.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432317.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2884
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2884
                     /product="dmX-like protein 2 isoform X3"
                     /calculated_mol_wt=322941
     Region          997..1728
                     /region_name="Rav1p_C"
                     /note="RAVE protein 1 C terminal; pfam12234"
                     /db_xref="CDD:432413"
     Region          2614..2866
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          2658..2698
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2703..2745
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2752..2787
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          2793..2829
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..2884
                     /gene="DMXL2"
                     /gene_synonym="DEE81; DFNA71; EIEE81; PEPNS; RC3"
                     /coded_by="XM_047432317.1:599..9253"
                     /db_xref="GeneID:23312"
                     /db_xref="HGNC:HGNC:2938"
                     /db_xref="MIM:612186"
ORIGIN      
        1 mewspdgeyf atagkddcll kvwypmtgwk ssiipqdhhe vkrrqsstqf sfvylahpra
       61 vtgfswrkts kymprgsvcn vlltschdgv crlwaetllp edcllgeqic etttssiass
      121 lshagrhkdr iqhaletihh lknlrkgqrr ssvlvthael mpdqtamhev qrhishhana
      181 lchfhiaasi npatdipnvl vgtafnvddg nggfvvhwln nkefhftsst evfmhqlrkl
      241 sdkqvdhend dadredeehs qedrerglhm kldhdlsldr eseagtgsse hedgeregsp
      301 rtysrlsvpm plptvlldrk ietlltewnk npdmlftihp vdgtflvwhv kyldeynpgi
      361 frqvqvsfss ripvafpsgd asslsknimm yacinatkds hhtllhqegm svgsphgsqp
      421 hsrshsthmn ilaptvmmis khidgslnqw avtfadksaf ttvltvshkf rycghrfhln
      481 dlachsvlpl lltsshhnal ltpeldcqwd sdnklsrlmd pvkhikgssk qplrnaatrt
      541 fhdpnaiyse lilwrvdpig plsytggvse larinslhts afsnvawlpt lipsyclgty
      601 cnsasacfva sdgknlrlyq avvdarklld elsdpesskl igevfnivsq qstarpgcii
      661 eldaitnqcg sntqllhvfq edfiigykph kedmekkete iffqpsqgyr pppfsekffl
      721 vviekdsnnn silhmwhlhl ksvqaclaka segassesll svpgqknvds spetspsvsp
      781 mphsssianl qtasklilss rlvysqpldl pesvevirat psaghlssss iypvclapyl
      841 vvttcsdnkv rfwkccmean pecnksdeke iyhwkrwplm ndegednsst vsivgrpvav
      901 scsytgrlav aykqpihhng fvskefsmhv cifecestgg sewvleqtih lddlvkvgsv
      961 ldsrvsvdsn lfvysksdal lskdrylipn ikhlvhldwv skedgshilt vgvganifmy
     1021 grlsgivteq tnskdgvavi tlplggsikq gvksrwvllr sidlvssvdg tpslpvslsw
     1081 vrdgilvvgm dcemhvyaqw khavkfgdte adssnaeeaa mqdhstfksn mlarksvveg
     1141 taisddvfcs ptviqdgglf eaahvlsptl pqyhptqlle lmdlgkvrra kailshlvkc
     1201 iagevaivrd pdagegtkrh lsrtisvsgs taketvtvgk dgtrdyteid sipplplyal
     1261 laadqdtsyr iseestkipq syedqtvsqp edqyselfqi qdiptddidl epekrenksk
     1321 vinlsqygpa yfgqeharvl sshlmhsslp gltrleqmfl valadtvatt steldesrdk
     1381 scsgrdtlde cglryllamr lhtclltslp plyrvqllhq gvstchfawa fhseaeeeli
     1441 nmipaiqrgd pqwselramg igwwvrnint lrrciekvak asfqrnndal daalfylsmk
     1501 kkavvwglfr sqhdekmttf fshnfnedrw rkaalknafs llgkqrfeqs aaffllagsl
     1561 kdaievclek mediqlamvi arlyesefet sstyisilnq kilgcqkdgs gfsckrlhpd
     1621 pflrslaywv mkdytraldt lleqtpkedd ehqviikscn pvafsfynyl rthpllirrn
     1681 laspegtlat lglkteknfv dkinlierkl ffttanahfk vgcpvlalev lskipkvtkt
     1741 salsakkdqp dfishrmddv pshskalsdg ngssgiewsn vtssqydwsq pivkvdeepl
     1801 nldwgedhds aldeeeddav glvmkstdar ekdkqsdqka sdpnmlltpq eeddpegdte
     1861 vdviaeqlkf raclkilmte lrtlatgyev dggklrfqly nwlekeiaal heicnhesvi
     1921 keyssktysk vesdlldqee mvdkpdigsy erhqierrrl qakrehaerr kswlqknqdl
     1981 lrvflsycsl hgaqggglas vrmelkfllq esqqettvkq lqsplplptt lpllsasias
     2041 tktvianpvl ylnnhihdil ytivqmktpp hpsiedvkvh tlhslaasls asiyqalcds
     2101 hsyssqtegn qftgmayqgl llsdrrrlrt esieehatpn sspaqwpgvs slinllssaq
     2161 dedqpklnil lceavvavyl sllihalatn ssselfrlaa hplnnrmwaa vfgggvklvv
     2221 kprrqsenis appvlsedid khrrrfnmrm lvpgrpvkda tpppvpaerp sykekfippe
     2281 lsmwdyfvak pflplsdsgv iydsdesihs deeddaffsd tqiqehqdpn syswallhlt
     2341 mvklalhnvk nffpiaglef selpvtsplg iaviknlenw eqilqekmdq fegpppnyin
     2401 typtdlsvga gpailrnkam lepentpfks rdssafpvkr lwhflvkqev lqetfiryif
     2461 tkkrkqsesi eehveqvnqn ciaedchikv eadlgypggk akvihkesdm imafsvnkan
     2521 cneivlasth dvqeldvtsl lacqsyiwig eeydreskss ddvdyrgstt tlyqpsatsy
     2581 sasqvhppss lpwlgtgqts tgasvlmkrn lhnvkrmtsh pvhqyyltga qdgsvrmfew
     2641 trpqqlvcfr qagnarvtrl yfnsqgnkcg vadgegflsi wqvnqtasnp kpymswqchs
     2701 katsdfafit ssslvatsgh sndnrnvclw dtlispgnsl ihgftchdhg atvlqyapkq
     2761 qllisggrkg hvcifdirqr qlihtfqahd saikalaldp yeeyfttgsa egnikvwrlt
     2821 ghglihsfks ehakqsifrn igagvmqidi iqgnrlfscg adgtlktrvl pnafnipnri
     2881 ldil
//
LOCUS       XP_047288274            2862 aa            linear   PRI 05-AUG-2025
DEFINITION  dmX-like protein 2 isoform X4 [Homo sapiens].
ACCESSION   XP_047288274
VERSION     XP_047288274.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432318.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2862
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2862
                     /product="dmX-like protein 2 isoform X4"
                     /calculated_mol_wt=320519
     Region          <45..268
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          61..102
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          109..171
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          174..225
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          235..268
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1171..1902
                     /region_name="Rav1p_C"
                     /note="RAVE protein 1 C terminal; pfam12234"
                     /db_xref="CDD:432413"
     CDS             1..2862
                     /gene="DMXL2"
                     /gene_synonym="DEE81; DFNA71; EIEE81; PEPNS; RC3"
                     /coded_by="XM_047432318.1:227..8815"
                     /db_xref="GeneID:23312"
                     /db_xref="HGNC:HGNC:2938"
                     /db_xref="MIM:612186"
ORIGIN      
        1 mhlhqvltga vnpgdncysv gsvgdvpfta ygsgcdivil andfecvqii pgakhgniqv
       61 scvecsnqqg riaasygnav cifeplgins hkrncqlkcq wlktgqffls svtynlawdp
      121 qdnrlltatd siqlwappgd dileeeeeid ntvppvlndw kcvwqcktsv svhlmewspd
      181 geyfatagkd dcllkvwypm tgwkssiipq dhhevkrrqs stqfsfvyla hpravtgfsw
      241 rktskymprg svcnvlltsc hdgvcrlwae tllpedcllg eqicetttss iasslshagr
      301 hkdriqhale tihhlknlrk gqrrssvlvt haelmpdqta mhevqrhish hanalchfhi
      361 aasinpatdi pnvlvgtafn vddgnggfvv hwlnnkefhf tsstevfmhq lrklsdkqvd
      421 henddadred eehsqedrer glhmkldhdl sldreseagt gssehedger egsprtysrl
      481 svpmplptvl ldrkietllt ewnknpdmlf tihpvdgtfl vwhvkyldey npgifrqvqv
      541 sfssripvaf psgdasslsk nimmyacina tkdshhtllh qegmsvgsph gsqphsrshs
      601 thmnilaptv mmiskhidgs lnqwavtfad ksafttvltv shkfrycghr fhlndlachs
      661 vlpllltssh hnalltpeld cqwdsdnkls rlmdpvkhik gsskqplrna atrtfhdpna
      721 iyselilwrv dpigplsytg gvselarins lhtsafsnva wlptlipsyc lgtycnsasa
      781 cfvasdgknl rlyqavvdar klldelsdpe sskligevfn ivsqqstarp gciieldait
      841 nqcgsntqll hvfqedfiig ykphkedmek keteiffqps qgyrpppfse kfflvviekd
      901 snnnsilhmw hlhlksvqac lakasegass esllsvpgqk nvdsspetsp svspmphsss
      961 ianlqtaskl ilssrlvysq pldlpesvev iratpsaghl ssssiypvcl apylvvttcs
     1021 dnkvrfwkcc meanpecnks dekeiyhwkr wplmndeged nsstvsivgr pvavscsytg
     1081 rlavaykqpi hhngfvskef smhvcifece stggsewvle qtihlddlvk vgsvldsrvs
     1141 vdsnlfvysk sdallskdry lipnikhlvh ldwvskedgs hiltvgvgan ifmygrlsgi
     1201 vteqtnskdg vavitlplgg sikqgvksrw vllrsidlvs svdgtpslpv slswvrdgil
     1261 vvgmdcemhv yaqwkhavkf gdteadssna eeaamqdhst fksnmlarks vvegtaisdd
     1321 vfcsptviqd gglfeaahvl sptlpqyhpt qllelmdlgk vrrakailsh lvkciageva
     1381 ivrdpdageg tkrhlsrtis vsgstaketv tvgkdgtrdy teidsipplp lyallaadqd
     1441 tsyriseest kipqsyedqt vsqpedqyse lfqiqdiptd didlepekre nkskvinlsq
     1501 ygpayfgqeh arvlsshlmh sslpgltrle qmflvaladt vattstelde srdkscsgrd
     1561 tldecglryl lamrlhtcll tslpplyrvq llhqgvstch fawafhseae eelinmipai
     1621 qrgdpqwsel ramgigwwvr nintlrrcie kvakasfqrn ndaldaalfy lsmkkkavvw
     1681 glfrsqhdek mttffshnfn edrwrkaalk nafsllgkqr feqsaaffll agslkdaiev
     1741 clekmediql amviarlyes efetsstyis ilnqkilgcq kdgsgfsckr lhpdpflrsl
     1801 aywvmkdytr aldtlleqtp keddehqvii kscnpvafsf ynylrthpll irrnlaspeg
     1861 tlatlglkte knfvdkinli erklffttan ahfkvgcpvl alevlskipk vtktsalsak
     1921 kdqpdfishr mddvpshska lsdgngssgi ewsnvtssqy dwsqpivkvd eeplnldwge
     1981 dhdsaldeee ddavglvmks tdarekdkqs dqkasdpnml ltpqeeddpe gdtevdviae
     2041 qlkfraclki lmtelrtlat gyevdggklr fqlynwleke iaalheicnh esvikeyssk
     2101 tyskvesdll dqeemvdkpd igsyerhqie rrrlqakreh aerrkswlqk nqdllrvfls
     2161 ycslhgaqgg glasvrmelk fllqesqqet tvkqlqsplp lpttlpllsa siastktvia
     2221 npvlylnnhi hdilytivqm ktpphpsied vkvhtlhsla aslsasiyqa lcdshsyssq
     2281 tegnqftgma yqglllsdrr rlrtesieeh atpnsspaqw pgvsslinll ssaqdedqpk
     2341 lnillceavv avylslliha latnssself rlaahplnnr mwaavfgggv klvvkprrqs
     2401 enisappvls edidkhrrrf nmrmlvpgrp vkdatpppvp aerpsykekf ippelsmwdy
     2461 fvakpflpls dsgviydsde sihsdeedda ffsdtqiqeh qdpnsyswal lhltmvklal
     2521 hnvknffpia glefselpvt splgiavikn lenweqilqe kmdqfegppp nyintyptdl
     2581 svgagpailr nkamlepent pfksrdssaf pvkrlwhflv kqevlqetfi ryiftkkrkq
     2641 sesieehveq vnqnciaedc hikveadlgy pggkakvihk esdmimafsv nkancneivl
     2701 asthdvqeld vtsllacqsy iwigeeydre skssddvdyr gstttlyqps atsysasqvh
     2761 ppsslpwlgt gqtstgasvl mkrnlhnvkr mtshpvhqyy ltgaqdgsvr mfewtrpqql
     2821 vcfrqagnar vtrlyfnsqg nkvsratimv prycsmhpns ns
//
LOCUS       XP_047288275            2595 aa            linear   PRI 05-AUG-2025
DEFINITION  dmX-like protein 2 isoform X5 [Homo sapiens].
ACCESSION   XP_047288275
VERSION     XP_047288275.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432319.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2595
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2595
                     /product="dmX-like protein 2 isoform X5"
                     /calculated_mol_wt=290668
     Region          <45..268
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          61..102
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          109..171
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          174..225
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          235..268
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1171..1902
                     /region_name="Rav1p_C"
                     /note="RAVE protein 1 C terminal; pfam12234"
                     /db_xref="CDD:432413"
     CDS             1..2595
                     /gene="DMXL2"
                     /gene_synonym="DEE81; DFNA71; EIEE81; PEPNS; RC3"
                     /coded_by="XM_047432319.1:227..8014"
                     /db_xref="GeneID:23312"
                     /db_xref="HGNC:HGNC:2938"
                     /db_xref="MIM:612186"
ORIGIN      
        1 mhlhqvltga vnpgdncysv gsvgdvpfta ygsgcdivil andfecvqii pgakhgniqv
       61 scvecsnqqg riaasygnav cifeplgins hkrncqlkcq wlktgqffls svtynlawdp
      121 qdnrlltatd siqlwappgd dileeeeeid ntvppvlndw kcvwqcktsv svhlmewspd
      181 geyfatagkd dcllkvwypm tgwkssiipq dhhevkrrqs stqfsfvyla hpravtgfsw
      241 rktskymprg svcnvlltsc hdgvcrlwae tllpedcllg eqicetttss iasslshagr
      301 hkdriqhale tihhlknlrk gqrrssvlvt haelmpdqta mhevqrhish hanalchfhi
      361 aasinpatdi pnvlvgtafn vddgnggfvv hwlnnkefhf tsstevfmhq lrklsdkqvd
      421 henddadred eehsqedrer glhmkldhdl sldreseagt gssehedger egsprtysrl
      481 svpmplptvl ldrkietllt ewnknpdmlf tihpvdgtfl vwhvkyldey npgifrqvqv
      541 sfssripvaf psgdasslsk nimmyacina tkdshhtllh qegmsvgsph gsqphsrshs
      601 thmnilaptv mmiskhidgs lnqwavtfad ksafttvltv shkfrycghr fhlndlachs
      661 vlpllltssh hnalltpeld cqwdsdnkls rlmdpvkhik gsskqplrna atrtfhdpna
      721 iyselilwrv dpigplsytg gvselarins lhtsafsnva wlptlipsyc lgtycnsasa
      781 cfvasdgknl rlyqavvdar klldelsdpe sskligevfn ivsqqstarp gciieldait
      841 nqcgsntqll hvfqedfiig ykphkedmek keteiffqps qgyrpppfse kfflvviekd
      901 snnnsilhmw hlhlksvqac lakasegass esllsvpgqk nvdsspetsp svspmphsss
      961 ianlqtaskl ilssrlvysq pldlpesvev iratpsaghl ssssiypvcl apylvvttcs
     1021 dnkvrfwkcc meanpecnks dekeiyhwkr wplmndeged nsstvsivgr pvavscsytg
     1081 rlavaykqpi hhngfvskef smhvcifece stggsewvle qtihlddlvk vgsvldsrvs
     1141 vdsnlfvysk sdallskdry lipnikhlvh ldwvskedgs hiltvgvgan ifmygrlsgi
     1201 vteqtnskdg vavitlplgg sikqgvksrw vllrsidlvs svdgtpslpv slswvrdgil
     1261 vvgmdcemhv yaqwkhavkf gdteadssna eeaamqdhst fksnmlarks vvegtaisdd
     1321 vfcsptviqd gglfeaahvl sptlpqyhpt qllelmdlgk vrrakailsh lvkciageva
     1381 ivrdpdageg tkrhlsrtis vsgstaketv tvgkdgtrdy teidsipplp lyallaadqd
     1441 tsyriseest kipqsyedqt vsqpedqyse lfqiqdiptd didlepekre nkskvinlsq
     1501 ygpayfgqeh arvlsshlmh sslpgltrle qmflvaladt vattstelde srdkscsgrd
     1561 tldecglryl lamrlhtcll tslpplyrvq llhqgvstch fawafhseae eelinmipai
     1621 qrgdpqwsel ramgigwwvr nintlrrcie kvakasfqrn ndaldaalfy lsmkkkavvw
     1681 glfrsqhdek mttffshnfn edrwrkaalk nafsllgkqr feqsaaffll agslkdaiev
     1741 clekmediql amviarlyes efetsstyis ilnqkilgcq kdgsgfsckr lhpdpflrsl
     1801 aywvmkdytr aldtlleqtp keddehqvii kscnpvafsf ynylrthpll irrnlaspeg
     1861 tlatlglkte knfvdkinli erklffttan ahfkvgcpvl alevlskipk vtktsalsak
     1921 kdqpdfishr mddvpshska lsdgngssgi ewsnvtssqy dwsqpivkvd eeplnldwge
     1981 dhdsaldeee ddavglvmks tdarekdkqs dqkasdpnml ltpqeeddpe gdtevdviae
     2041 qlkfraclki lmtelrtlat gyevdggklr fqlynwleke iaalheicnh esvikeyssk
     2101 tyskvesdll dqeemvdkpd igsyerhqie rrrlqakreh aerrkswlqk nqdllrvfls
     2161 ycslhgaqgg glasvrmelk fllqesqqet tvkqlqsplp lpttlpllsa siastktvia
     2221 npvlylnnhi hdilytivqm ktpphpsied vkvhtlhsla aslsasiyqa lcdshsyssq
     2281 tegnqftgma yqglllsdrr rlrtesieeh atpnsspaqw pgvsslinll ssaqdedqpk
     2341 lnillceavv avylslliha latnssself rlaahplnnr mwaavfgggv klvvkprrqs
     2401 enisappvls edidkhrrrf nmrmlvpgrp vkdatpppvp aerpsykekf ippelsmwdy
     2461 fvakpflpls dsgviydsde sihsdeedda ffsdtqiqeh qdpnsyswal lhltmvklal
     2521 hnvknffpia glefsgpgil lhfqsndfgi sllnkrsfkr hlldifslrk esrvrlkliw
     2581 aiqverrkss irnli
//
LOCUS       XP_047288276            2594 aa            linear   PRI 05-AUG-2025
DEFINITION  dmX-like protein 2 isoform X6 [Homo sapiens].
ACCESSION   XP_047288276
VERSION     XP_047288276.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432320.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2594
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2594
                     /product="dmX-like protein 2 isoform X6"
                     /calculated_mol_wt=290581
     Region          <45..268
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          61..102
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          109..171
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          174..225
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          235..268
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1171..1902
                     /region_name="Rav1p_C"
                     /note="RAVE protein 1 C terminal; pfam12234"
                     /db_xref="CDD:432413"
     CDS             1..2594
                     /gene="DMXL2"
                     /gene_synonym="DEE81; DFNA71; EIEE81; PEPNS; RC3"
                     /coded_by="XM_047432320.1:227..8011"
                     /db_xref="GeneID:23312"
                     /db_xref="HGNC:HGNC:2938"
                     /db_xref="MIM:612186"
ORIGIN      
        1 mhlhqvltga vnpgdncysv gsvgdvpfta ygsgcdivil andfecvqii pgakhgniqv
       61 scvecsnqqg riaasygnav cifeplgins hkrncqlkcq wlktgqffls svtynlawdp
      121 qdnrlltatd siqlwappgd dileeeeeid ntvppvlndw kcvwqcktsv svhlmewspd
      181 geyfatagkd dcllkvwypm tgwkssiipq dhhevkrrqs stqfsfvyla hpravtgfsw
      241 rktskymprg svcnvlltsc hdgvcrlwae tllpedcllg eqicetttss iasslshagr
      301 hkdriqhale tihhlknlrk gqrrssvlvt haelmpdqta mhevqrhish hanalchfhi
      361 aasinpatdi pnvlvgtafn vddgnggfvv hwlnnkefhf tsstevfmhq lrklsdkqvd
      421 henddadred eehsqedrer glhmkldhdl sldreseagt gssehedger egsprtysrl
      481 svpmplptvl ldrkietllt ewnknpdmlf tihpvdgtfl vwhvkyldey npgifrqvqv
      541 sfssripvaf psgdasslsk nimmyacina tkdshhtllh qegmsvgsph gsqphsrshs
      601 thmnilaptv mmiskhidgs lnqwavtfad ksafttvltv shkfrycghr fhlndlachs
      661 vlpllltssh hnalltpeld cqwdsdnkls rlmdpvkhik gsskqplrna atrtfhdpna
      721 iyselilwrv dpigplsytg gvselarins lhtsafsnva wlptlipsyc lgtycnsasa
      781 cfvasdgknl rlyqavvdar klldelsdpe sskligevfn ivsqqstarp gciieldait
      841 nqcgsntqll hvfqedfiig ykphkedmek keteiffqps qgyrpppfse kfflvviekd
      901 snnnsilhmw hlhlksvqac lakasegass esllsvpgqk nvdsspetsp svspmphsss
      961 ianlqtaskl ilssrlvysq pldlpesvev iratpsaghl ssssiypvcl apylvvttcs
     1021 dnkvrfwkcc meanpecnks dekeiyhwkr wplmndeged nsstvsivgr pvavscsytg
     1081 rlavaykqpi hhngfvskef smhvcifece stggsewvle qtihlddlvk vgsvldsrvs
     1141 vdsnlfvysk sdallskdry lipnikhlvh ldwvskedgs hiltvgvgan ifmygrlsgi
     1201 vteqtnskdg vavitlplgg sikqgvksrw vllrsidlvs svdgtpslpv slswvrdgil
     1261 vvgmdcemhv yaqwkhavkf gdteadssna eeaamqdhst fksnmlarks vvegtaisdd
     1321 vfcsptviqd gglfeaahvl sptlpqyhpt qllelmdlgk vrrakailsh lvkciageva
     1381 ivrdpdageg tkrhlsrtis vsgstaketv tvgkdgtrdy teidsipplp lyallaadqd
     1441 tsyriseest kipqsyedqt vsqpedqyse lfqiqdiptd didlepekre nkskvinlsq
     1501 ygpayfgqeh arvlsshlmh sslpgltrle qmflvaladt vattstelde srdkscsgrd
     1561 tldecglryl lamrlhtcll tslpplyrvq llhqgvstch fawafhseae eelinmipai
     1621 qrgdpqwsel ramgigwwvr nintlrrcie kvakasfqrn ndaldaalfy lsmkkkavvw
     1681 glfrsqhdek mttffshnfn edrwrkaalk nafsllgkqr feqsaaffll agslkdaiev
     1741 clekmediql amviarlyes efetsstyis ilnqkilgcq kdgsgfsckr lhpdpflrsl
     1801 aywvmkdytr aldtlleqtp keddehqvii kscnpvafsf ynylrthpll irrnlaspeg
     1861 tlatlglkte knfvdkinli erklffttan ahfkvgcpvl alevlskipk vtktsalsak
     1921 kdqpdfishr mddvpshska lsdgngssgi ewsnvtssqy dwsqpivkvd eeplnldwge
     1981 dhdsaldeee ddavglvmks tdarekdkqs dqkasdpnml ltpqeeddpe gdtevdviae
     2041 qlkfraclki lmtelrtlat gyevdggklr fqlynwleke iaalheicnh esvikeyssk
     2101 tyskvesdll dqeemvdkpd igsyerhqie rrrlqakreh aerrkswlqk nqdllrvfls
     2161 ycslhgaqgg glasvrmelk fllqesqqet tvkqlqsplp lpttlpllsa siastktvia
     2221 npvlylnnhi hdilytivqm ktpphpsied vkvhtlhsla aslsasiyqa lcdshsysqt
     2281 egnqftgmay qglllsdrrr lrtesieeha tpnsspaqwp gvsslinlls saqdedqpkl
     2341 nillceavva vylsllihal atnssselfr laahplnnrm waavfgggvk lvvkprrqse
     2401 nisappvlse didkhrrrfn mrmlvpgrpv kdatpppvpa erpsykekfi ppelsmwdyf
     2461 vakpflplsd sgviydsdes ihsdeeddaf fsdtqiqehq dpnsyswall hltmvklalh
     2521 nvknffpiag lefsgpgill hfqsndfgis llnkrsfkrh lldifslrke srvrlkliwa
     2581 iqverrkssi rnli
//
LOCUS       XP_047288277            1585 aa            linear   PRI 05-AUG-2025
DEFINITION  dmX-like protein 2 isoform X7 [Homo sapiens].
ACCESSION   XP_047288277
VERSION     XP_047288277.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432321.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1585
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1585
                     /product="dmX-like protein 2 isoform X7"
                     /calculated_mol_wt=175962
     Region          <45..268
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          61..102
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          109..171
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          174..225
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          235..268
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..1585
                     /gene="DMXL2"
                     /gene_synonym="DEE81; DFNA71; EIEE81; PEPNS; RC3"
                     /coded_by="XM_047432321.1:227..4984"
                     /db_xref="GeneID:23312"
                     /db_xref="HGNC:HGNC:2938"
                     /db_xref="MIM:612186"
ORIGIN      
        1 mhlhqvltga vnpgdncysv gsvgdvpfta ygsgcdivil andfecvqii pgakhgniqv
       61 scvecsnqqg riaasygnav cifeplgins hkrncqlkcq wlktgqffls svtynlawdp
      121 qdnrlltatd siqlwappgd dileeeeeid ntvppvlndw kcvwqcktsv svhlmewspd
      181 geyfatagkd dcllkvwypm tgwkssiipq dhhevkrrqs stqfsfvyla hpravtgfsw
      241 rktskymprg svcnvlltsc hdgvcrlwae tllpedcllg eqicetttss iasslshagr
      301 hkdriqhale tihhlknlrk gqrrssvlvt haelmpdqta mhevqrhish hanalchfhi
      361 aasinpatdi pnvlvgtafn vddgnggfvv hwlnnkefhf tsstevfmhq lrklsdkqvd
      421 henddadred eehsqedrer glhmkldhdl sldreseagt gssehedger egsprtysrl
      481 svpmplptvl ldrkietllt ewnknpdmlf tihpvdgtfl vwhvkyldey npgifrqvqv
      541 sfssripvaf psgdasslsk nimmyacina tkdshhtllh qegmsvgsph gsqphsrshs
      601 thmnilaptv mmiskhidgs lnqwavtfad ksafttvltv shkfrycghr fhlndlachs
      661 vlpllltssh hnalltpeld cqwdsdnkls rlmdpvkhik gsskqplrna atrtfhdpna
      721 iyselilwrv dpigplsytg gvselarins lhtsafsnva wlptlipsyc lgtycnsasa
      781 cfvasdgknl rlyqavvdar klldelsdpe sskligevfn ivsqqstarp gciieldait
      841 nqcgsntqll hvfqedfiig ykphkedmek keteiffqps qgyrpppfse kfflvviekd
      901 snnnsilhmw hlhlksvqac lakasegass esllsvpgqk nvdsspetsp svspmphsss
      961 ianlqtaskl ilssrlvysq pldlpesvev iratpsaghl ssssiypvcl apylvvttcs
     1021 dnkvrfwkcc meanpecnks dekeiyhwkr wplmndeged nsstvsivgr pvavscsytg
     1081 rlavaykqpi hhngfvskef smhvcifece stggsewvle qtihlddlvk vgsvldsrvs
     1141 vdsnlfvysk sdallskdry lipnikhlvh ldwvskedgs hiltvgvgan ifmygrlsgi
     1201 vteqtnskdg vavitlplgg sikqgvksrw vllrsidlvs svdgtpslpv slswvrdgil
     1261 vvgmdcemhv yaqwkhavkf gdteadssna eeaamqdhst fksnmlarks vvegtaisdd
     1321 vfcsptviqd gglfeaahvl sptlpqyhpt qllelmdlgk vrrakailsh lvkciageva
     1381 ivrdpdageg tkrhlsrtis vsgstaketv tvgkdgtrdy teidsipplp lyallaadqd
     1441 tsyriseest kipqsyedqt vsqpedqyse lfqiqdiptd didlepekre nkskvinlsq
     1501 ygpayfgqeh arvlsshlmh sslpgltrle qmflvaladt vattstelde srdkscsvst
     1561 fklcrektsl ignyyyiics vrkdg
//
LOCUS       XP_016877524            1200 aa            linear   PRI 05-AUG-2025
DEFINITION  synemin isoform X1 [Homo sapiens].
ACCESSION   XP_016877524
VERSION     XP_016877524.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022035.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1200
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1200
                     /product="synemin isoform X1"
                     /calculated_mol_wt=133939
     Region          11..318
                     /region_name="Filament"
                     /note="Intermediate filament protein; pfam00038"
                     /db_xref="CDD:459643"
     Region          <192..>576
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     CDS             1..1200
                     /gene="SYNM"
                     /gene_synonym="DMN; SYN"
                     /coded_by="XM_017022035.2:121..3723"
                     /db_xref="GeneID:23336"
                     /db_xref="HGNC:HGNC:24466"
                     /db_xref="MIM:606087"
ORIGIN      
        1 mlswrlqtgp ekaelqelna rlydyvcrvr elerenllle eelrgrrgre glwaegqarc
       61 aeearslrqq ldelswatal aegerdalrr elrelqrlda eeraargrld aelgaqqrel
      121 qealgaraal eallgrlqae rrgldaaher dvrelraraa sltmhfrara tgpaappprl
      181 revhdsyall vaeswretvq lyedevrele ealrrgqesr lqaeeetrlc aqeaealrre
      241 algleqlrar ledallrmre eygiqaeerq rvidcledek atltlamadw lrdyqdllqv
      301 ktglslevat yrallegesn peiviwaehv enmpsefrnk syhytdsllq renernlfsr
      361 qkaplasfnh ssalysnlsg hrgsqtgtsi ggdarrgflg sgysssattq qensygkavs
      421 sqtnvrtfsp tygllrntea qvktfpdrpk agdtrevpvy igedstiare syrdrrdkva
      481 agasestrsn ertvilgkkt evkatreqer nrpetirtkp eekmfdskek aseernlrwe
      541 eltkldkear qresqqmkek akekdspkek svrerevpis levsqdrrae vspkglqtpv
      601 kdagggtgre aearelrfrl gtsdatgslq gdsmtetvae nivtsilkqf tqspeteasa
      661 dsfpdtkvty vdrkelpger ktkteivves kltedvdvsd eagldyllsk dikevglkgk
      721 saeqmigdii nlglkgregr akvvnveive epvsyvsgek peefsvpfkv eevedvspgp
      781 wglvkeeegy gesdvtfsvn qhrrtkqpqe ntthveevte agdsegeqsy fvstpdehpg
      841 ghdrddgsvy gqihieeest iryswqdeiv qgtrrrtqkd gavgekvvkp ldvpapsleg
      901 dlgsthwkeq arsgefhaep tviekeikip hefhtsmkgi sskeprqqlv evigqleetl
      961 permreelsa ltregqggpg svsvdvkkvq gaggssvtlv aevnvsqtvd adrldleels
     1021 kdeasemeka vesvvresls rqrspapgsp deeggaeapa agirfrrwat relyipsges
     1081 evaggashss gqrtpqgpvs atvevssptg faqsqvledv sqaarhiklg psevwrterm
     1141 syegptaevv efwklgslkv ptvsfpgegs lpglqtavfs lcphmverei islvsllikh
//
LOCUS       XP_011519705             907 aa            linear   PRI 05-AUG-2025
DEFINITION  vam6/Vps39-like protein isoform X1 [Homo sapiens].
ACCESSION   XP_011519705
VERSION     XP_011519705.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521403.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..907
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..907
                     /product="vam6/Vps39-like protein isoform X1"
                     /calculated_mol_wt=104187
     Region          24..290
                     /region_name="CNH"
                     /note="CNH domain; cl02434"
                     /db_xref="CDD:470577"
     Region          460..562
                     /region_name="Vps39_1"
                     /note="Vacuolar sorting protein 39 domain 1; pfam10366"
                     /db_xref="CDD:371008"
     Region          595..746
                     /region_name="Clathrin"
                     /note="Region in Clathrin and VPS; pfam00637"
                     /db_xref="CDD:459884"
     Region          772..862
                     /region_name="Vps39_2"
                     /note="Vacuolar sorting protein 39 domain 2; pfam10367"
                     /db_xref="CDD:402126"
     CDS             1..907
                     /gene="VPS39"
                     /gene_synonym="hVam6p; TLP; VAM6"
                     /coded_by="XM_011521403.3:152..2875"
                     /db_xref="GeneID:23339"
                     /db_xref="HGNC:HGNC:20593"
                     /db_xref="MIM:612188"
ORIGIN      
        1 mhdafepvpi leklplqidc laaweewllv gtkqghllly rirkdvvpad vaspesgscn
       61 rfevtleksn knfskkiqqi hvvsqfkilv sllenniyvh dlltfqqitt vskakgaslf
      121 tcdlqhtetg eevlrmcvav kkklqlyfwk drefhelqgd fsvpdvpksm awcensicvg
      181 fkrdyylirv dgkgsikelf ptgkqleplv apladgkvav gqddltvvln eegictqkca
      241 lnwtdipvam ehqppyiiav lpryveirtf eprllvqsie lqrprfitsg gsniiyvasn
      301 hfvwrlipvp matqiqqllq dkqfelalql aemkddsdse kqqqihhikn lyafnlfcqk
      361 rfdesmqvfa klgtdpthvm glypdllptd yrkqlqypnp lpvlsgaele kahlalidyl
      421 tqkrsqlvkk lndsdhqsst splmegtpti kskkkllqii dttllkcylh tnvalvapll
      481 rlennhchie esehvlkkah kyseliilye kkglhekalq vlvdqskkan splkghertv
      541 qylqhlgten lhlifsysvw vlrdfpedgl kiftedlpev eslprdrvlg flienfkgla
      601 ipylehiihv weetgsrfhn cliqlycekv qglmkeylls fpagktpvpa geeegelgey
      661 rqkllmflei ssyydpgrli cdfpfdglle eralllgrmg kheqalfiyv hilkdtrmae
      721 eychkhydrn kdgnkdvyls llrmylspps ihclgpikle llepkanlqa alqvlelhhs
      781 kldttkalnl lpantqindi riflekvlee naqkkrfnqv lknllhaefl rvqeerilhq
      841 qvkciiteek vcmvckkkig nrrcrcqrsg hleavltpkp fsslqcicki pqwsgrplll
      901 fqrgkps
//
LOCUS       XP_011519706             896 aa            linear   PRI 05-AUG-2025
DEFINITION  vam6/Vps39-like protein isoform X2 [Homo sapiens].
ACCESSION   XP_011519706
VERSION     XP_011519706.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521404.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..896
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..896
                     /product="vam6/Vps39-like protein isoform X2"
                     /calculated_mol_wt=103147
     Region          24..279
                     /region_name="CNH"
                     /note="CNH domain; cl02434"
                     /db_xref="CDD:470577"
     Region          449..551
                     /region_name="Vps39_1"
                     /note="Vacuolar sorting protein 39 domain 1; pfam10366"
                     /db_xref="CDD:371008"
     Region          584..735
                     /region_name="Clathrin"
                     /note="Region in Clathrin and VPS; pfam00637"
                     /db_xref="CDD:459884"
     Region          761..851
                     /region_name="Vps39_2"
                     /note="Vacuolar sorting protein 39 domain 2; pfam10367"
                     /db_xref="CDD:402126"
     CDS             1..896
                     /gene="VPS39"
                     /gene_synonym="hVam6p; TLP; VAM6"
                     /coded_by="XM_011521404.3:152..2842"
                     /db_xref="GeneID:23339"
                     /db_xref="HGNC:HGNC:20593"
                     /db_xref="MIM:612188"
ORIGIN      
        1 mhdafepvpi leklplqidc laaweewllv gtkqghllly rirkdvgcnr fevtleksnk
       61 nfskkiqqih vvsqfkilvs llenniyvhd lltfqqittv skakgaslft cdlqhtetge
      121 evlrmcvavk kklqlyfwkd refhelqgdf svpdvpksma wcensicvgf krdyylirvd
      181 gkgsikelfp tgkqleplva pladgkvavg qddltvvlne egictqkcal nwtdipvame
      241 hqppyiiavl pryveirtfe prllvqsiel qrprfitsgg sniiyvasnh fvwrlipvpm
      301 atqiqqllqd kqfelalqla emkddsdsek qqqihhiknl yafnlfcqkr fdesmqvfak
      361 lgtdpthvmg lypdllptdy rkqlqypnpl pvlsgaelek ahlalidylt qkrsqlvkkl
      421 ndsdhqssts plmegtptik skkkllqiid ttllkcylht nvalvapllr lennhchiee
      481 sehvlkkahk yseliilyek kglhekalqv lvdqskkans plkghertvq ylqhlgtenl
      541 hlifsysvwv lrdfpedglk iftedlpeve slprdrvlgf lienfkglai pylehiihvw
      601 eetgsrfhnc liqlycekvq glmkeyllsf pagktpvpag eeegelgeyr qkllmfleis
      661 syydpgrlic dfpfdgllee ralllgrmgk heqalfiyvh ilkdtrmaee ychkhydrnk
      721 dgnkdvylsl lrmylsppsi hclgpiklel lepkanlqaa lqvlelhhsk ldttkalnll
      781 pantqindir iflekvleen aqkkrfnqvl knllhaeflr vqeerilhqq vkciiteekv
      841 cmvckkkign rrcrcqrsgh leavltpkpf sslqcickip qwsgrplllf qrgkps
//
LOCUS       XP_047288278             648 aa            linear   PRI 05-AUG-2025
DEFINITION  vam6/Vps39-like protein isoform X3 [Homo sapiens].
ACCESSION   XP_047288278
VERSION     XP_047288278.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432322.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..648
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..648
                     /product="vam6/Vps39-like protein isoform X3"
                     /calculated_mol_wt=74195
     Region          24..290
                     /region_name="CNH"
                     /note="CNH domain; cl02434"
                     /db_xref="CDD:470577"
     Region          460..562
                     /region_name="Vps39_1"
                     /note="Vacuolar sorting protein 39 domain 1; pfam10366"
                     /db_xref="CDD:371008"
     CDS             1..648
                     /gene="VPS39"
                     /gene_synonym="hVam6p; TLP; VAM6"
                     /coded_by="XM_047432322.1:152..2098"
                     /db_xref="GeneID:23339"
                     /db_xref="HGNC:HGNC:20593"
                     /db_xref="MIM:612188"
ORIGIN      
        1 mhdafepvpi leklplqidc laaweewllv gtkqghllly rirkdvvpad vaspesgscn
       61 rfevtleksn knfskkiqqi hvvsqfkilv sllenniyvh dlltfqqitt vskakgaslf
      121 tcdlqhtetg eevlrmcvav kkklqlyfwk drefhelqgd fsvpdvpksm awcensicvg
      181 fkrdyylirv dgkgsikelf ptgkqleplv apladgkvav gqddltvvln eegictqkca
      241 lnwtdipvam ehqppyiiav lpryveirtf eprllvqsie lqrprfitsg gsniiyvasn
      301 hfvwrlipvp matqiqqllq dkqfelalql aemkddsdse kqqqihhikn lyafnlfcqk
      361 rfdesmqvfa klgtdpthvm glypdllptd yrkqlqypnp lpvlsgaele kahlalidyl
      421 tqkrsqlvkk lndsdhqsst splmegtpti kskkkllqii dttllkcylh tnvalvapll
      481 rlennhchie esehvlkkah kyseliilye kkglhekalq vlvdqskkan splkghertv
      541 qylqhlgten lhlifsysvw vlrdfpedgl kiftedlpev eslprdrvlg flienfkgla
      601 ipylehiihv weetgsrfhn cliqlycekv qglmkeylls fpagaqkf
//
LOCUS       XP_011519709             615 aa            linear   PRI 05-AUG-2025
DEFINITION  protein ENTREP2 isoform X1 [Homo sapiens].
ACCESSION   XP_011519709
VERSION     XP_011519709.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521407.3
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XP_011519709.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 17% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..615
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..615
                     /product="protein ENTREP2 isoform X1"
                     /calculated_mol_wt=64600
     Region          34..159
                     /region_name="CD20"
                     /note="CD20-like family; pfam04103"
                     /db_xref="CDD:461174"
     Region          <347..554
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..615
                     /gene="ENTREP2"
                     /gene_synonym="FAM189A1; TMEM228"
                     /coded_by="XM_011521407.3:257..2104"
                     /db_xref="GeneID:23359"
                     /db_xref="HGNC:HGNC:29075"
                     /db_xref="MIM:620052"
ORIGIN      
        1 mppaggprap rpaalprsls rlrecpgrsr ivlalgatqm algclivavs faalalttsa
       61 rvrhscpfwa gfsvllsgli gvvswkrpls lvitffmlls avcvmlnlag silscqnaql
      121 vnslegcqli kfdsvevcvc celqhqssgc snlgetlkln plqencnavr ltlkssmggl
      181 rlvdkqrcte redaahlhgr ttpgsqrlsc farrngpswm vpaahqsdrc sgvggikncs
      241 tpgpipswdq dllfsvcaln vlstivcala tamccmqmvs sdvlqmflpq rshpanptcv
      301 tphgtvlhqt ldfdefippl ppppyyppey tctpsteaqr glhldfapsp fgtlydvain
      361 spgllypael pppyeavvgq ppasqvtsig qqvaesssgd pntsagfstp vpadstsllv
      421 segtatpgss pspdgpvgap apsepalppg hvspedpgmg sqvqpgpgrv srstsdptlc
      481 tssmagdass hrpscsqdle aglseavpgs asmsrsataa craqlspagd pdtwktdqrp
      541 tpepfpatsk erprslvdsk ayadarvlva kflehshcal pteaqhmvga mrlavtneer
      601 leeeavfgad vldqv
//
LOCUS       XP_047288279             545 aa            linear   PRI 05-AUG-2025
DEFINITION  protein ENTREP2 isoform X2 [Homo sapiens].
ACCESSION   XP_047288279
VERSION     XP_047288279.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432323.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 15% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..545
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..545
                     /product="protein ENTREP2 isoform X2"
                     /calculated_mol_wt=57051
     Region          34..199
                     /region_name="CD20"
                     /note="CD20-like family; pfam04103"
                     /db_xref="CDD:461174"
     Region          <271..478
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..545
                     /gene="ENTREP2"
                     /gene_synonym="FAM189A1; TMEM228"
                     /coded_by="XM_047432323.1:257..1894"
                     /db_xref="GeneID:23359"
                     /db_xref="HGNC:HGNC:29075"
                     /db_xref="MIM:620052"
ORIGIN      
        1 mppaggprap rpaalprsls rlrecpgrsr ivlalgatqm algclivavs faalalttsa
       61 rvrhscpfwa gfsvllsgli gvvswkrpls lvitffmlls avcvmlnlag silscqnaql
      121 vnslegcqli kfdsvevcvc celqhqssgc snlgetlkln plqencnavr ltlkdllfsv
      181 calnvlstiv calatamccm qmvssdvlqm flpqrshpan ptcvtphgtv lhqtldfdef
      241 ipplppppyy ppeytctpst eaqrglhldf apspfgtlyd vainspglly paelpppyea
      301 vvgqppasqv tsigqqvaes ssgdpntsag fstpvpadst sllvsegtat pgsspspdgp
      361 vgapapsepa lppghvsped pgmgsqvqpg pgrvsrstsd ptlctssmag dasshrpscs
      421 qdleaglsea vpgsasmsrs ataacraqls pagdpdtwkt dqrptpepfp atskerprsl
      481 vdskayadar vlvakflehs hcalpteaqh mvgamrlavt neerleeeav fgadvldqfp
      541 knpgp
//
LOCUS       XP_047288280            1062 aa            linear   PRI 05-AUG-2025
DEFINITION  AP-4 complex subunit epsilon-1 isoform X1 [Homo sapiens].
ACCESSION   XP_047288280
VERSION     XP_047288280.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432324.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1062
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1062
                     /product="AP-4 complex subunit epsilon-1 isoform X1"
                     /calculated_mol_wt=119352
     Region          3..521
                     /region_name="Adaptin_N"
                     /note="Adaptin N terminal region; pfam01602"
                     /db_xref="CDD:396262"
     Region          958..1058
                     /region_name="AP4E_app_platf"
                     /note="Adaptin AP4 complex epsilon appendage platform;
                     pfam14807"
                     /db_xref="CDD:464326"
     CDS             1..1062
                     /gene="AP4E1"
                     /gene_synonym="CPSQ4; SPG51; STUT1"
                     /coded_by="XM_047432324.1:213..3401"
                     /db_xref="GeneID:23431"
                     /db_xref="HGNC:HGNC:573"
                     /db_xref="MIM:607244"
ORIGIN      
        1 mmkecmvrli ycemlgydas fgyihaikla qqgnllekrv gylavslflh eshelllllv
       61 ntvvkdlqst nlvevcmalt vvsqifpcem ipavlplied klqhskeivr rkavlalykf
      121 hliapnqvqh ihikfrkalc drdvgvmaas lhiylrmike nssgykdltg sfvtilkqvv
      181 ggklpvefny hsvpapwlqi qllrilgllg kddqrtselm ydvldeslrr aelnhnvtya
      241 ilfecvhtvy siypkselle kaakcigkfv lspkinlkyl glkaltyviq qdptlalqhq
      301 mtiiecldhp dpiikretle llyritnaqn itvivqkmle ylhqskeeyv ivnlvgkiae
      361 laekyapdna wfiqtmnavf svggdvmhpd ipnnflrlla egfddetedq qlrlyavqsy
      421 ltlldmenvf ypqrflqvms wvlgeysyll dketpeevia klykllmnds vssetkawli
      481 aavtkltsqa hssntverli heftisldtc mrqhafelkh lhenvelmks llpvdrsced
      541 lvvdaslsfl dgfvaeglsq gaapykpphq rqeeklsqek vlnfepygls fsssgftgrq
      601 spagislgsd vsgnsaetgl ketnslkleg ikklwgkegy lpkkesktgd esgalpvpqe
      661 simenvdqai tkkdqsqvlt qskeekekql lasslfvglg sestinllgk adtvshkfrr
      721 kskvkeaksg ettsthnmtc ssfsslsnva yeddyysntl hdtgdkelkk fsltsellds
      781 esltelplve kfsycslstp slfannnmei fhppqstaas vakesslass fleetteyih
      841 snamevcnne tisvssykiw kddcllmvws vtnksglelk sadleifpae nfkvteqpgc
      901 clpvmeaest ksfqysvqie kpftegnltg fisyhmmdth saqlefsvnl slldfirplk
      961 issddfgklw lsfandvkqn vkmsesqaal psalktlqqk lrlhiieiig negllacqll
     1021 psipcllhcr vhadvlalwf rsscstlpdy llyqcqkvme gs
//
LOCUS       XP_006720510            1062 aa            linear   PRI 05-AUG-2025
DEFINITION  AP-4 complex subunit epsilon-1 isoform X1 [Homo sapiens].
ACCESSION   XP_006720510
VERSION     XP_006720510.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720447.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1062
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1062
                     /product="AP-4 complex subunit epsilon-1 isoform X1"
                     /calculated_mol_wt=119352
     Region          3..521
                     /region_name="Adaptin_N"
                     /note="Adaptin N terminal region; pfam01602"
                     /db_xref="CDD:396262"
     Region          958..1058
                     /region_name="AP4E_app_platf"
                     /note="Adaptin AP4 complex epsilon appendage platform;
                     pfam14807"
                     /db_xref="CDD:464326"
     CDS             1..1062
                     /gene="AP4E1"
                     /gene_synonym="CPSQ4; SPG51; STUT1"
                     /coded_by="XM_006720447.5:511..3699"
                     /db_xref="GeneID:23431"
                     /db_xref="HGNC:HGNC:573"
                     /db_xref="MIM:607244"
ORIGIN      
        1 mmkecmvrli ycemlgydas fgyihaikla qqgnllekrv gylavslflh eshelllllv
       61 ntvvkdlqst nlvevcmalt vvsqifpcem ipavlplied klqhskeivr rkavlalykf
      121 hliapnqvqh ihikfrkalc drdvgvmaas lhiylrmike nssgykdltg sfvtilkqvv
      181 ggklpvefny hsvpapwlqi qllrilgllg kddqrtselm ydvldeslrr aelnhnvtya
      241 ilfecvhtvy siypkselle kaakcigkfv lspkinlkyl glkaltyviq qdptlalqhq
      301 mtiiecldhp dpiikretle llyritnaqn itvivqkmle ylhqskeeyv ivnlvgkiae
      361 laekyapdna wfiqtmnavf svggdvmhpd ipnnflrlla egfddetedq qlrlyavqsy
      421 ltlldmenvf ypqrflqvms wvlgeysyll dketpeevia klykllmnds vssetkawli
      481 aavtkltsqa hssntverli heftisldtc mrqhafelkh lhenvelmks llpvdrsced
      541 lvvdaslsfl dgfvaeglsq gaapykpphq rqeeklsqek vlnfepygls fsssgftgrq
      601 spagislgsd vsgnsaetgl ketnslkleg ikklwgkegy lpkkesktgd esgalpvpqe
      661 simenvdqai tkkdqsqvlt qskeekekql lasslfvglg sestinllgk adtvshkfrr
      721 kskvkeaksg ettsthnmtc ssfsslsnva yeddyysntl hdtgdkelkk fsltsellds
      781 esltelplve kfsycslstp slfannnmei fhppqstaas vakesslass fleetteyih
      841 snamevcnne tisvssykiw kddcllmvws vtnksglelk sadleifpae nfkvteqpgc
      901 clpvmeaest ksfqysvqie kpftegnltg fisyhmmdth saqlefsvnl slldfirplk
      961 issddfgklw lsfandvkqn vkmsesqaal psalktlqqk lrlhiieiig negllacqll
     1021 psipcllhcr vhadvlalwf rsscstlpdy llyqcqkvme gs
//
LOCUS       XP_005254321            1062 aa            linear   PRI 05-AUG-2025
DEFINITION  AP-4 complex subunit epsilon-1 isoform X1 [Homo sapiens].
ACCESSION   XP_005254321
VERSION     XP_005254321.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254264.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1062
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1062
                     /product="AP-4 complex subunit epsilon-1 isoform X1"
                     /calculated_mol_wt=119352
     Region          3..521
                     /region_name="Adaptin_N"
                     /note="Adaptin N terminal region; pfam01602"
                     /db_xref="CDD:396262"
     Region          958..1058
                     /region_name="AP4E_app_platf"
                     /note="Adaptin AP4 complex epsilon appendage platform;
                     pfam14807"
                     /db_xref="CDD:464326"
     CDS             1..1062
                     /gene="AP4E1"
                     /gene_synonym="CPSQ4; SPG51; STUT1"
                     /coded_by="XM_005254264.5:1228..4416"
                     /db_xref="GeneID:23431"
                     /db_xref="HGNC:HGNC:573"
                     /db_xref="MIM:607244"
ORIGIN      
        1 mmkecmvrli ycemlgydas fgyihaikla qqgnllekrv gylavslflh eshelllllv
       61 ntvvkdlqst nlvevcmalt vvsqifpcem ipavlplied klqhskeivr rkavlalykf
      121 hliapnqvqh ihikfrkalc drdvgvmaas lhiylrmike nssgykdltg sfvtilkqvv
      181 ggklpvefny hsvpapwlqi qllrilgllg kddqrtselm ydvldeslrr aelnhnvtya
      241 ilfecvhtvy siypkselle kaakcigkfv lspkinlkyl glkaltyviq qdptlalqhq
      301 mtiiecldhp dpiikretle llyritnaqn itvivqkmle ylhqskeeyv ivnlvgkiae
      361 laekyapdna wfiqtmnavf svggdvmhpd ipnnflrlla egfddetedq qlrlyavqsy
      421 ltlldmenvf ypqrflqvms wvlgeysyll dketpeevia klykllmnds vssetkawli
      481 aavtkltsqa hssntverli heftisldtc mrqhafelkh lhenvelmks llpvdrsced
      541 lvvdaslsfl dgfvaeglsq gaapykpphq rqeeklsqek vlnfepygls fsssgftgrq
      601 spagislgsd vsgnsaetgl ketnslkleg ikklwgkegy lpkkesktgd esgalpvpqe
      661 simenvdqai tkkdqsqvlt qskeekekql lasslfvglg sestinllgk adtvshkfrr
      721 kskvkeaksg ettsthnmtc ssfsslsnva yeddyysntl hdtgdkelkk fsltsellds
      781 esltelplve kfsycslstp slfannnmei fhppqstaas vakesslass fleetteyih
      841 snamevcnne tisvssykiw kddcllmvws vtnksglelk sadleifpae nfkvteqpgc
      901 clpvmeaest ksfqysvqie kpftegnltg fisyhmmdth saqlefsvnl slldfirplk
      961 issddfgklw lsfandvkqn vkmsesqaal psalktlqqk lrlhiieiig negllacqll
     1021 psipcllhcr vhadvlalwf rsscstlpdy llyqcqkvme gs
//
LOCUS       XP_047288281            1062 aa            linear   PRI 05-AUG-2025
DEFINITION  AP-4 complex subunit epsilon-1 isoform X1 [Homo sapiens].
ACCESSION   XP_047288281
VERSION     XP_047288281.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432325.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1062
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1062
                     /product="AP-4 complex subunit epsilon-1 isoform X1"
                     /calculated_mol_wt=119352
     Region          3..521
                     /region_name="Adaptin_N"
                     /note="Adaptin N terminal region; pfam01602"
                     /db_xref="CDD:396262"
     Region          958..1058
                     /region_name="AP4E_app_platf"
                     /note="Adaptin AP4 complex epsilon appendage platform;
                     pfam14807"
                     /db_xref="CDD:464326"
     CDS             1..1062
                     /gene="AP4E1"
                     /gene_synonym="CPSQ4; SPG51; STUT1"
                     /coded_by="XM_047432325.1:534..3722"
                     /db_xref="GeneID:23431"
                     /db_xref="HGNC:HGNC:573"
                     /db_xref="MIM:607244"
ORIGIN      
        1 mmkecmvrli ycemlgydas fgyihaikla qqgnllekrv gylavslflh eshelllllv
       61 ntvvkdlqst nlvevcmalt vvsqifpcem ipavlplied klqhskeivr rkavlalykf
      121 hliapnqvqh ihikfrkalc drdvgvmaas lhiylrmike nssgykdltg sfvtilkqvv
      181 ggklpvefny hsvpapwlqi qllrilgllg kddqrtselm ydvldeslrr aelnhnvtya
      241 ilfecvhtvy siypkselle kaakcigkfv lspkinlkyl glkaltyviq qdptlalqhq
      301 mtiiecldhp dpiikretle llyritnaqn itvivqkmle ylhqskeeyv ivnlvgkiae
      361 laekyapdna wfiqtmnavf svggdvmhpd ipnnflrlla egfddetedq qlrlyavqsy
      421 ltlldmenvf ypqrflqvms wvlgeysyll dketpeevia klykllmnds vssetkawli
      481 aavtkltsqa hssntverli heftisldtc mrqhafelkh lhenvelmks llpvdrsced
      541 lvvdaslsfl dgfvaeglsq gaapykpphq rqeeklsqek vlnfepygls fsssgftgrq
      601 spagislgsd vsgnsaetgl ketnslkleg ikklwgkegy lpkkesktgd esgalpvpqe
      661 simenvdqai tkkdqsqvlt qskeekekql lasslfvglg sestinllgk adtvshkfrr
      721 kskvkeaksg ettsthnmtc ssfsslsnva yeddyysntl hdtgdkelkk fsltsellds
      781 esltelplve kfsycslstp slfannnmei fhppqstaas vakesslass fleetteyih
      841 snamevcnne tisvssykiw kddcllmvws vtnksglelk sadleifpae nfkvteqpgc
      901 clpvmeaest ksfqysvqie kpftegnltg fisyhmmdth saqlefsvnl slldfirplk
      961 issddfgklw lsfandvkqn vkmsesqaal psalktlqqk lrlhiieiig negllacqll
     1021 psipcllhcr vhadvlalwf rsscstlpdy llyqcqkvme gs
//
LOCUS       XP_047288282             899 aa            linear   PRI 05-AUG-2025
DEFINITION  AP-4 complex subunit epsilon-1 isoform X2 [Homo sapiens].
ACCESSION   XP_047288282
VERSION     XP_047288282.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432326.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..899
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..899
                     /product="AP-4 complex subunit epsilon-1 isoform X2"
                     /calculated_mol_wt=101098
     Region          3..521
                     /region_name="Adaptin_N"
                     /note="Adaptin N terminal region; pfam01602"
                     /db_xref="CDD:396262"
     CDS             1..899
                     /gene="AP4E1"
                     /gene_synonym="CPSQ4; SPG51; STUT1"
                     /coded_by="XM_047432326.1:213..2912"
                     /db_xref="GeneID:23431"
                     /db_xref="HGNC:HGNC:573"
                     /db_xref="MIM:607244"
ORIGIN      
        1 mmkecmvrli ycemlgydas fgyihaikla qqgnllekrv gylavslflh eshelllllv
       61 ntvvkdlqst nlvevcmalt vvsqifpcem ipavlplied klqhskeivr rkavlalykf
      121 hliapnqvqh ihikfrkalc drdvgvmaas lhiylrmike nssgykdltg sfvtilkqvv
      181 ggklpvefny hsvpapwlqi qllrilgllg kddqrtselm ydvldeslrr aelnhnvtya
      241 ilfecvhtvy siypkselle kaakcigkfv lspkinlkyl glkaltyviq qdptlalqhq
      301 mtiiecldhp dpiikretle llyritnaqn itvivqkmle ylhqskeeyv ivnlvgkiae
      361 laekyapdna wfiqtmnavf svggdvmhpd ipnnflrlla egfddetedq qlrlyavqsy
      421 ltlldmenvf ypqrflqvms wvlgeysyll dketpeevia klykllmnds vssetkawli
      481 aavtkltsqa hssntverli heftisldtc mrqhafelkh lhenvelmks llpvdrsced
      541 lvvdaslsfl dgfvaeglsq gaapykpphq rqeeklsqek vlnfepygls fsssgftgrq
      601 spagislgsd vsgnsaetgl ketnslkleg ikklwgkegy lpkkesktgd esgalpvpqe
      661 simenvdqai tkkdqsqvlt qskeekekql lasslfvglg sestinllgk adtvshkfrr
      721 kskvkeaksg ettsthnmtc ssfsslsnva yeddyysntl hdtgdkelkk fsltsellds
      781 esltelplve kfsycslstp slfannnmei fhppqstaas vakesslass fleetteyih
      841 snamevcnne tisvssykiw kddcllmvws vtnksglelk sadleifpae nfktiknlk
//
LOCUS       XP_047288283             687 aa            linear   PRI 05-AUG-2025
DEFINITION  AP-4 complex subunit epsilon-1 isoform X3 [Homo sapiens].
ACCESSION   XP_047288283
VERSION     XP_047288283.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432327.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..687
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..687
                     /product="AP-4 complex subunit epsilon-1 isoform X3"
                     /calculated_mol_wt=76466
     Region          583..683
                     /region_name="AP4E_app_platf"
                     /note="Adaptin AP4 complex epsilon appendage platform;
                     pfam14807"
                     /db_xref="CDD:464326"
     CDS             1..687
                     /gene="AP4E1"
                     /gene_synonym="CPSQ4; SPG51; STUT1"
                     /coded_by="XM_047432327.1:122..2185"
                     /db_xref="GeneID:23431"
                     /db_xref="HGNC:HGNC:573"
                     /db_xref="MIM:607244"
ORIGIN      
        1 mnavfsvggd vmhpdipnnf lrllaegfdd etedqqlrly avqsyltlld menvfypqrf
       61 lqvmswvlge ysylldketp eeviaklykl lmndsvsset kawliaavtk ltsqahssnt
      121 verlihefti sldtcmrqha felkhlhenv elmksllpvd rscedlvvda slsfldgfva
      181 eglsqgaapy kpphqrqeek lsqekvlnfe pyglsfsssg ftgrqspagi slgsdvsgns
      241 aetglketns lklegikklw gkegylpkke sktgdesgal pvpqesimen vdqaitkkdq
      301 sqvltqskee kekqllassl fvglgsesti nllgkadtvs hkfrrkskvk eaksgettst
      361 hnmtcssfss lsnvayeddy ysntlhdtgd kelkkfslts elldseslte lplvekfsyc
      421 slstpslfan nnmeifhppq staasvakes slassfleet teyihsname vcnnetisvs
      481 sykiwkddcl lmvwsvtnks glelksadle ifpaenfkvt eqpgcclpvm eaestksfqy
      541 svqiekpfte gnltgfisyh mmdthsaqle fsvnlslldf irplkissdd fgklwlsfan
      601 dvkqnvkmse sqaalpsalk tlqqklrlhi ieiignegll acqllpsipc llhcrvhadv
      661 lalwfrsscs tlpdyllyqc qkvmegs
//
LOCUS       XP_047288284             199 aa            linear   PRI 05-AUG-2025
DEFINITION  cyclin-D1-binding protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047288284
VERSION     XP_047288284.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432328.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..199
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..199
                     /product="cyclin-D1-binding protein 1 isoform X1"
                     /calculated_mol_wt=22227
     Region          <1..159
                     /region_name="GCIP"
                     /note="Grap2 and cyclin-D-interacting; pfam13324"
                     /db_xref="CDD:463844"
     CDS             1..199
                     /gene="CCNDBP1"
                     /gene_synonym="DIP1; GCIP; HHM"
                     /coded_by="XM_047432328.1:143..742"
                     /db_xref="GeneID:23582"
                     /db_xref="HGNC:HGNC:1587"
                     /db_xref="MIM:607089"
ORIGIN      
        1 mpqiprdnka aallmltknv dfvkdaheem eqaveecdpy sgllndteen nsdnhnhedd
       61 vlgfpsnqdl ywseddqeli ipclalvras kaclkkirml vaengkkdqv aqlddivdis
      121 deispsvddl alsiyppmch ltvrinsakl vsvlkkalei tkashvtpqp edswipllin
      181 aidhcmnrik eltqselel
//
LOCUS       XP_047288290             433 aa            linear   PRI 05-AUG-2025
DEFINITION  lysophospholipid acyltransferase LPCAT4 isoform X1 [Homo sapiens].
ACCESSION   XP_047288290
VERSION     XP_047288290.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432334.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..433
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..433
                     /product="lysophospholipid acyltransferase LPCAT4 isoform
                     X1"
                     /calculated_mol_wt=47309
     Region          109..306
                     /region_name="LPLAT_LPCAT1-like"
                     /note="Lysophospholipid Acyltransferases (LPLATs) of
                     Glycerophospholipid Biosynthesis: LPCAT1-like; cd07991"
                     /db_xref="CDD:153253"
     Site            order(129,132,134,148..151,204..206)
                     /site_type="active"
                     /note="putative acyl-acceptor binding pocket [active]"
                     /db_xref="CDD:153253"
     CDS             1..433
                     /gene="LPCAT4"
                     /gene_synonym="AGPAT7; AYTL3; LPAAT-eta; LPEAT2; LPLAT10"
                     /coded_by="XM_047432334.1:97..1398"
                     /db_xref="GeneID:254531"
                     /db_xref="HGNC:HGNC:30059"
                     /db_xref="MIM:612039"
ORIGIN      
        1 msqgspgdwa pldptpgppa spnpfvhelh lsrlqrvkfc llgallapir vllafivlfl
       61 lwpfawlqva glseeqlqep itgwrktvch ngvlglsrll ffllgflrir vrgqrasrlq
      121 apvlvaaphs tffdpivllp cdlpkvvsra enlsvpviga llrfnqailv srhdpasrrr
      181 vveevrrrat sggkwpqvlf fpegtcsnkk allkfkpgaf iagvpvqpvl irypnsldtt
      241 swawrgpgvl kvlwltasqp csivdveflp vyhpspeesr dptlyannvq rvmaqalgip
      301 atecefvgsl pvivvgrlkv alepqlwelg kvlrkaglsa gyvdagaepg rsrmisqeef
      361 arqlqlsdpq tvagafgyfq qassalksnv iimrrnkgei iryqgfgglp rcgpctsssg
      421 wgqepgrans sgl
//
LOCUS       XP_006720517             409 aa            linear   PRI 05-AUG-2025
DEFINITION  lysophospholipid acyltransferase LPCAT4 isoform X2 [Homo sapiens].
ACCESSION   XP_006720517
VERSION     XP_006720517.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720454.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..409
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..409
                     /product="lysophospholipid acyltransferase LPCAT4 isoform
                     X2"
                     /calculated_mol_wt=45001
     Region          109..306
                     /region_name="LPLAT_LPCAT1-like"
                     /note="Lysophospholipid Acyltransferases (LPLATs) of
                     Glycerophospholipid Biosynthesis: LPCAT1-like; cd07991"
                     /db_xref="CDD:153253"
     Site            order(129,132,134,148..151,204..206)
                     /site_type="active"
                     /note="putative acyl-acceptor binding pocket [active]"
                     /db_xref="CDD:153253"
     CDS             1..409
                     /gene="LPCAT4"
                     /gene_synonym="AGPAT7; AYTL3; LPAAT-eta; LPEAT2; LPLAT10"
                     /coded_by="XM_006720454.2:97..1326"
                     /db_xref="GeneID:254531"
                     /db_xref="HGNC:HGNC:30059"
                     /db_xref="MIM:612039"
ORIGIN      
        1 msqgspgdwa pldptpgppa spnpfvhelh lsrlqrvkfc llgallapir vllafivlfl
       61 lwpfawlqva glseeqlqep itgwrktvch ngvlglsrll ffllgflrir vrgqrasrlq
      121 apvlvaaphs tffdpivllp cdlpkvvsra enlsvpviga llrfnqailv srhdpasrrr
      181 vveevrrrat sggkwpqvlf fpegtcsnkk allkfkpgaf iagvpvqpvl irypnsldtt
      241 swawrgpgvl kvlwltasqp csivdveflp vyhpspeesr dptlyannvq rvmaqalgip
      301 atecefvgsl pvivvgrlkv alepqlwelg kvlrkaglsa gyvdagaepg rsrmisqeef
      361 arqlqlsdpq tvagafgyfq qassalksnv iimrrnkgei imvprsfli
//
LOCUS       XP_011519725             235 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 57 isoform X1 [Homo
            sapiens].
ACCESSION   XP_011519725
VERSION     XP_011519725.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521423.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..235
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..235
                     /product="leucine-rich repeat-containing protein 57
                     isoform X1"
                     /calculated_mol_wt=25881
     Region          <38..>225
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          40..63
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          64..86
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          87..109
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          110..132
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          133..154
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          155..177
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     CDS             1..235
                     /gene="LRRC57"
                     /coded_by="XM_011521423.4:124..831"
                     /db_xref="GeneID:255252"
                     /db_xref="HGNC:HGNC:26719"
ORIGIN      
        1 mgnsalrahv etaqktgvfq lkdrgltefp adlqkltsnl rtidlsnnki eslpplligk
       61 ftllkslsln nnkltvlpde icnlkkletl slnnnhlrel pstfgqlsal ktlslsgnql
      121 galppqlcsl rhldvmdlsk nqirsipdsv gelqvielnl nqnqisqisv kisccprlki
      181 lrleenclel smlpqsilsd sqicllaveg nlfeikklre legydkgsct aklis
//
LOCUS       XP_011519726             233 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 57 isoform X2 [Homo
            sapiens].
ACCESSION   XP_011519726
VERSION     XP_011519726.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521424.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..233
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..233
                     /product="leucine-rich repeat-containing protein 57
                     isoform X2"
                     /calculated_mol_wt=25736
     Region          <38..>229
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          40..63
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          64..86
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          87..109
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          110..132
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          133..154
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          155..177
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     CDS             1..233
                     /gene="LRRC57"
                     /coded_by="XM_011521424.4:124..825"
                     /db_xref="GeneID:255252"
                     /db_xref="HGNC:HGNC:26719"
ORIGIN      
        1 mgnsalrahv etaqktgvfq lkdrgltefp adlqkltsnl rtidlsnnki eslpplligk
       61 ftllkslsln nnkltvlpde icnlkkletl slnnnhlrel pstfgqlsal ktlslsgnql
      121 galppqlcsl rhldvmdlsk nqirsipdsv gelqvielnl nqnqisqisv kisccprlki
      181 lrleenclel smlpqsilsd sqicllaveg nlfeikklre legydkillc clg
//
LOCUS       XP_047288291             239 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 57 isoform X3 [Homo
            sapiens].
ACCESSION   XP_047288291
VERSION     XP_047288291.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432335.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..239
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..239
                     /product="leucine-rich repeat-containing protein 57
                     isoform X3"
                     /calculated_mol_wt=26623
     Region          <38..>225
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          40..63
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          64..86
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          87..109
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          110..132
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          133..154
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          155..177
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          178..199
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     CDS             1..239
                     /gene="LRRC57"
                     /coded_by="XM_047432335.1:40..759"
                     /db_xref="GeneID:255252"
                     /db_xref="HGNC:HGNC:26719"
ORIGIN      
        1 mgnsalrahv etaqktgvfq lkdrgltefp adlqkltsnl rtidlsnnki eslpplligk
       61 ftllkslsln nnkltvlpde icnlkkletl slnnnhlrel pstfgqlsal ktlslsgnql
      121 galppqlcsl rhldvmdlsk nqirsipdsv gelqvielnl nqnqisqisv kisccprlki
      181 lrleenclel smlpqsilsd sqicllaveg nlfeikklre legydkymer ftatkkkfa
//
LOCUS       XP_047288292             419 aa            linear   PRI 05-AUG-2025
DEFINITION  GA-binding protein subunit beta-1 isoform X1 [Homo sapiens].
ACCESSION   XP_047288292
VERSION     XP_047288292.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432336.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..419
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..419
                     /product="GA-binding protein subunit beta-1 isoform X1"
                     /calculated_mol_wt=45552
     Region          <34..203
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          34..59
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          62..92
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(63,67..68,71..73,75..76,80,83,92,94,96,100..101,
                     104..106,108..109,113,116,125,127,129,133..134,137..139,
                     141..142,146,149)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          94..125
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          127..157
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          <365..411
                     /region_name="ERM_helical"
                     /note="Ezrin/radixin/moesin, alpha-helical domain;
                     pfam20492"
                     /db_xref="CDD:466641"
     CDS             1..419
                     /gene="GABPB1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4TF1B;
                     GABPB; GABPB-1; GABPB2; NRF2B1; NRF2B2"
                     /coded_by="XM_047432336.1:2726..3985"
                     /db_xref="GeneID:2553"
                     /db_xref="HGNC:HGNC:4074"
                     /db_xref="MIM:600610"
ORIGIN      
        1 mwwdvlrlwl lkesyprrkf fisfmslvdl gkklleaara gqddevrilm angapfttdw
       61 lgtsplhlaa qyghysttev llragvsrda rtkvdrtplh maaseghasi vevllkhgad
      121 vnakdmlkmt alhwatehnh qevvelliky gadvhtqskf cktafdisid ngnedlaeil
      181 qiamqnqint npespdtvti haatpqfiig pggvvnltgl vssensskat detgvsavqf
      241 gnsstsvlat laalaeasap lsnssetpvv ateevvtaes vdgaiqqvvs sggqqvitiv
      301 tdgiqlgnlh siptsgigqp iivtmpdgqq vltvpatdia eetviseepp akrqcieiie
      361 nrvesaeiee realqkqlde anreaqkyrq qllkkeqeae ayrqkleamt rlqtnkeav
//
LOCUS       XP_024305651             400 aa            linear   PRI 05-AUG-2025
DEFINITION  GA-binding protein subunit beta-1 isoform X2 [Homo sapiens].
ACCESSION   XP_024305651
VERSION     XP_024305651.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449883.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..400
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..400
                     /product="GA-binding protein subunit beta-1 isoform X2"
                     /calculated_mol_wt=42952
     Region          <15..184
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          15..40
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          43..73
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(44,48..49,52..54,56..57,61,64,73,75,77,81..82,
                     85..87,89..90,94,97,106,108,110,114..115,118..120,
                     122..123,127,130)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          75..106
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          108..138
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          340..387
                     /region_name="MobB_NDR_LATS-like"
                     /note="Mob-binding domain found in the NDR/LATS family
                     serine/threonine protein kinases; cl45907"
                     /db_xref="CDD:459252"
     CDS             1..400
                     /gene="GABPB1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4TF1B;
                     GABPB; GABPB-1; GABPB2; NRF2B1; NRF2B2"
                     /coded_by="XM_024449883.2:258..1460"
                     /db_xref="GeneID:2553"
                     /db_xref="HGNC:HGNC:4074"
                     /db_xref="MIM:600610"
ORIGIN      
        1 mklvkmslvd lgkklleaar agqddevril mangapfttd wlgtsplhla aqyghystte
       61 vllragvsrd artkvdrtpl hmaaseghas ivevllkhga dvnakdmlkm talhwatehn
      121 hqevvellik ygadvhtqsk fcktafdisi dngnedlaei lqiamqnqin tnpespdtvt
      181 ihaatpqfii gpggvvnltg lvssensska tdetgvsavq fgnsstsvla tlaalaeasa
      241 plsnssetpv vateevvtae svdgaiqqvv ssggqqviti vtdgiqlgnl hsiptsgigq
      301 piivtmpdgq qvltvpatdi aeetviseep pakrqcieii enrvesaeie erealqkqld
      361 eanreaqkyr qqllkkeqea eayrqkleam trlqtnkeav
//
LOCUS       XP_005254331             395 aa            linear   PRI 05-AUG-2025
DEFINITION  GA-binding protein subunit beta-1 isoform X3 [Homo sapiens].
ACCESSION   XP_005254331
VERSION     XP_005254331.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254274.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..395
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..395
                     /product="GA-binding protein subunit beta-1 isoform X3"
                     /calculated_mol_wt=42352
     Region          <10..179
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          10..35
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          38..68
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(39,43..44,47..49,51..52,56,59,68,70,72,76..77,
                     80..82,84..85,89,92,101,103,105,109..110,113..115,
                     117..118,122,125)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          70..101
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          103..133
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          335..382
                     /region_name="MobB_NDR_LATS-like"
                     /note="Mob-binding domain found in the NDR/LATS family
                     serine/threonine protein kinases; cl45907"
                     /db_xref="CDD:459252"
     CDS             1..395
                     /gene="GABPB1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4TF1B;
                     GABPB; GABPB-1; GABPB2; NRF2B1; NRF2B2"
                     /coded_by="XM_005254274.5:160..1347"
                     /db_xref="GeneID:2553"
                     /db_xref="HGNC:HGNC:4074"
                     /db_xref="MIM:600610"
ORIGIN      
        1 mslvdlgkkl leaaragqdd evrilmanga pfttdwlgts plhlaaqygh ysttevllra
       61 gvsrdartkv drtplhmaas eghasivevl lkhgadvnak dmlkmtalhw atehnhqevv
      121 ellikygadv htqskfckta fdisidngne dlaeilqiam qnqintnpes pdtvtihaat
      181 pqfiigpggv vnltglvsse nsskatdetg vsavqfgnss tsvlatlaal aeasaplsns
      241 setpvvatee vvtaesvdga iqqvvssggq qvitivtdgi qlgnlhsipt sgigqpiivt
      301 mpdgqqvltv patdiaeetv iseeppakrq cieiienrve saeieereal qkqldeanre
      361 aqkyrqqllk keqeaeayrq kleamtrlqt nkeav
//
LOCUS       XP_024305654             394 aa            linear   PRI 05-AUG-2025
DEFINITION  GA-binding protein subunit beta-1 isoform X4 [Homo sapiens].
ACCESSION   XP_024305654
VERSION     XP_024305654.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449886.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..394
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..394
                     /product="GA-binding protein subunit beta-1 isoform X4"
                     /calculated_mol_wt=42253
     Region          <10..179
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          10..35
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          38..68
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(39,43..44,47..49,51..52,56,59,68,70,72,76..77,
                     80..82,84..85,89,92,101,103,105,109..110,113..115,
                     117..118,122,125)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          70..101
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          103..133
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          334..381
                     /region_name="MobB_NDR_LATS-like"
                     /note="Mob-binding domain found in the NDR/LATS family
                     serine/threonine protein kinases; cl45907"
                     /db_xref="CDD:459252"
     CDS             1..394
                     /gene="GABPB1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4TF1B;
                     GABPB; GABPB-1; GABPB2; NRF2B1; NRF2B2"
                     /coded_by="XM_024449886.2:215..1399"
                     /db_xref="GeneID:2553"
                     /db_xref="HGNC:HGNC:4074"
                     /db_xref="MIM:600610"
ORIGIN      
        1 mslvdlgkkl leaaragqdd evrilmanga pfttdwlgts plhlaaqygh ysttevllra
       61 gvsrdartkv drtplhmaas eghasivevl lkhgadvnak dmlkmtalhw atehnhqevv
      121 ellikygadv htqskfckta fdisidngne dlaeilqiam qnqintnpes pdtvtihaat
      181 pqfiigpggv vnltglvsse nsskatdetg vsavqfgnss tsvlatlaal aeasaplsns
      241 setpvateev vtaesvdgai qqvvssggqq vitivtdgiq lgnlhsipts gigqpiivtm
      301 pdgqqvltvp atdiaeetvi seeppakrqc ieiienrves aeieerealq kqldeanrea
      361 qkyrqqllkk eqeaeayrqk leamtrlqtn keav
//
LOCUS       XP_047288293             386 aa            linear   PRI 05-AUG-2025
DEFINITION  GA-binding protein subunit beta-1 isoform X5 [Homo sapiens].
ACCESSION   XP_047288293
VERSION     XP_047288293.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432337.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..386
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..386
                     /product="GA-binding protein subunit beta-1 isoform X5"
                     /calculated_mol_wt=41553
     Region          <13..182
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          13..38
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          41..71
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(42,46..47,50..52,54..55,59,62,71,73,75,79..80,
                     83..85,87..88,92,95,104,106,108,112..113,116..118,
                     120..121,125,128)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          73..104
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          106..136
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          326..373
                     /region_name="MobB_NDR_LATS-like"
                     /note="Mob-binding domain found in the NDR/LATS family
                     serine/threonine protein kinases; cl45907"
                     /db_xref="CDD:459252"
     CDS             1..386
                     /gene="GABPB1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4TF1B;
                     GABPB; GABPB-1; GABPB2; NRF2B1; NRF2B2"
                     /coded_by="XM_047432337.1:228..1388"
                     /db_xref="GeneID:2553"
                     /db_xref="HGNC:HGNC:4074"
                     /db_xref="MIM:600610"
ORIGIN      
        1 mckmslvdlg kklleaarag qddevrilma ngapfttdwl gtsplhlaaq yghysttevl
       61 lragvsrdar tkvdrtplhm aaseghasiv evllkhgadv nakdmlkmta lhwatehnhq
      121 evvellikyg advhtqskfc ktafdisidn gnedlaeilq iamqnqintn pespdtvtih
      181 aatpqfiigp ggvvnltdet gvsavqfgns stsvlatlaa laeasaplsn ssetpvvate
      241 evvtaesvdg aiqqvvssgg qqvitivtdg iqlgnlhsip tsgigqpiiv tmpdgqqvlt
      301 vpatdiaeet viseeppakr qcieiienrv esaeieerea lqkqldeanr eaqkyrqqll
      361 kkeqeaeayr qkleamtrlq tnkeav
//
LOCUS       XP_016877542             383 aa            linear   PRI 05-AUG-2025
DEFINITION  GA-binding protein subunit beta-1 isoform X6 [Homo sapiens].
ACCESSION   XP_016877542
VERSION     XP_016877542.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022053.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..383
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..383
                     /product="GA-binding protein subunit beta-1 isoform X6"
                     /calculated_mol_wt=41190
     Region          <10..179
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          10..35
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          38..68
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(39,43..44,47..49,51..52,56,59,68,70,72,76..77,
                     80..82,84..85,89,92,101,103,105,109..110,113..115,
                     117..118,122,125)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          70..101
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          103..133
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          323..370
                     /region_name="MobB_NDR_LATS-like"
                     /note="Mob-binding domain found in the NDR/LATS family
                     serine/threonine protein kinases; cl45907"
                     /db_xref="CDD:459252"
     CDS             1..383
                     /gene="GABPB1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4TF1B;
                     GABPB; GABPB-1; GABPB2; NRF2B1; NRF2B2"
                     /coded_by="XM_017022053.3:239..1390"
                     /db_xref="GeneID:2553"
                     /db_xref="HGNC:HGNC:4074"
                     /db_xref="MIM:600610"
ORIGIN      
        1 mslvdlgkkl leaaragqdd evrilmanga pfttdwlgts plhlaaqygh ysttevllra
       61 gvsrdartkv drtplhmaas eghasivevl lkhgadvnak dmlkmtalhw atehnhqevv
      121 ellikygadv htqskfckta fdisidngne dlaeilqiam qnqintnpes pdtvtihaat
      181 pqfiigpggv vnltdetgvs avqfgnssts vlatlaalae asaplsnsse tpvvateevv
      241 taesvdgaiq qvvssggqqv itivtdgiql gnlhsiptsg igqpiivtmp dgqqvltvpa
      301 tdiaeetvis eeppakrqci eiienrvesa eieerealqk qldeanreaq kyrqqllkke
      361 qeaeayrqkl eamtrlqtnk eav
//
LOCUS       XP_011519728             382 aa            linear   PRI 05-AUG-2025
DEFINITION  GA-binding protein subunit beta-1 isoform X7 [Homo sapiens].
ACCESSION   XP_011519728
VERSION     XP_011519728.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521426.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..382
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..382
                     /product="GA-binding protein subunit beta-1 isoform X7"
                     /calculated_mol_wt=41091
     Region          <10..179
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          10..35
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          38..68
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(39,43..44,47..49,51..52,56,59,68,70,72,76..77,
                     80..82,84..85,89,92,101,103,105,109..110,113..115,
                     117..118,122,125)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          70..101
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          103..133
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          322..369
                     /region_name="MobB_NDR_LATS-like"
                     /note="Mob-binding domain found in the NDR/LATS family
                     serine/threonine protein kinases; cl45907"
                     /db_xref="CDD:459252"
     CDS             1..382
                     /gene="GABPB1"
                     /gene_synonym="BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4TF1B;
                     GABPB; GABPB-1; GABPB2; NRF2B1; NRF2B2"
                     /coded_by="XM_011521426.4:215..1363"
                     /db_xref="GeneID:2553"
                     /db_xref="HGNC:HGNC:4074"
                     /db_xref="MIM:600610"
ORIGIN      
        1 mslvdlgkkl leaaragqdd evrilmanga pfttdwlgts plhlaaqygh ysttevllra
       61 gvsrdartkv drtplhmaas eghasivevl lkhgadvnak dmlkmtalhw atehnhqevv
      121 ellikygadv htqskfckta fdisidngne dlaeilqiam qnqintnpes pdtvtihaat
      181 pqfiigpggv vnltdetgvs avqfgnssts vlatlaalae asaplsnsse tpvateevvt
      241 aesvdgaiqq vvssggqqvi tivtdgiqlg nlhsiptsgi gqpiivtmpd gqqvltvpat
      301 diaeetvise eppakrqcie iienrvesae ieerealqkq ldeanreaqk yrqqllkkeq
      361 eaeayrqkle amtrlqtnke av
//
LOCUS       XP_005268315             462 aa            linear   PRI 05-AUG-2025
DEFINITION  gamma-aminobutyric acid receptor subunit alpha-5 isoform X1 [Homo
            sapiens].
ACCESSION   XP_005268315
VERSION     XP_005268315.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005268258.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..462
                     /product="gamma-aminobutyric acid receptor subunit alpha-5
                     isoform X1"
                     /calculated_mol_wt=52015
     Region          58..256
                     /region_name="LGIC_ECD_GABAAR_A5"
                     /note="extracellular domain of gamma-aminobutyric acid
                     receptor subunit alpha-5 (GABAAR-A5 or GABRA5); cd19038"
                     /db_xref="CDD:349839"
     Site            order(71,99)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:349839"
     Site            order(83,85..86,91..92,99,101..102,119,121..122,131..136,
                     139,141,143..144,150..152,154,164..166,194,256)
                     /site_type="other"
                     /note="pentamer interface [polypeptide binding]"
                     /db_xref="CDD:349839"
     Region          173..187
                     /region_name="Cys-loop"
                     /note="Cys-loop [structural motif]"
                     /db_xref="CDD:349839"
     Region          259..445
                     /region_name="LGIC_TM_GABAAR_alpha"
                     /note="transmembrane domain of alpha subunits of type-A
                     gamma-aminobutyric acid receptor (GABAAR); cd19052"
                     /db_xref="CDD:349854"
     Site            order(259,262..263,270..271,273..274,277,280..282,
                     285..288,290..292,294..295,298..299,305..306,308..309,
                     316..317,328,332,335,339,342..343,430)
                     /site_type="other"
                     /note="pentamer interface [polypeptide binding]"
                     /db_xref="CDD:349854"
     Region          259..282
                     /region_name="TM1 helix"
                     /note="TM1 helix [structural motif]"
                     /db_xref="CDD:349854"
     Site            order(273,276..277,280,336,339..340,434)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:349854"
     Region          286..310
                     /region_name="TM2 helix"
                     /note="TM2 helix [structural motif]"
                     /db_xref="CDD:349854"
     Region          318..344
                     /region_name="TM3 helix"
                     /note="TM3 helix [structural motif]"
                     /db_xref="CDD:349854"
     Region          421..445
                     /region_name="TM4 helix"
                     /note="TM4 helix [structural motif]"
                     /db_xref="CDD:349854"
     CDS             1..462
                     /gene="GABRA5"
                     /gene_synonym="DEE79; EIEE79"
                     /coded_by="XM_005268258.3:425..1813"
                     /db_xref="GeneID:2558"
                     /db_xref="HGNC:HGNC:4079"
                     /db_xref="MIM:137142"
ORIGIN      
        1 mdngmfsgfi miknlllfci smnlsshfgf sqmptssvkd etndnitift rildglldgy
       61 dnrlrpglge ritqvrtdiy vtsfgpvsdt emeytidvff rqswkderlr fkgpmqrlpl
      121 nnllaskiwt pdtffhngkk siahnmttpn kllrleddgt llytmrltis aecpmqledf
      181 pmdahacplk fgsyaypnse vvyvwtngst ksvvvaedgs rlnqyhlmgq tvgtenists
      241 tgeytimtah fhlkrkigyf viqtylpcim tvilsqvsfw lnresvpart vfgvttvltm
      301 ttlsisarns lpkvayatam dwfiavcyaf vfsaliefat vnyftkrgwa wdgkkaleaa
      361 kikkkrevil nkstnafttg kmshppnipk eqtpagtsnt tsvsvkpsee ktseskktyn
      421 siskidkmsr ivfpvlfgtf nlvywatyln repvikgaas pk
//
LOCUS       XP_006720522             462 aa            linear   PRI 05-AUG-2025
DEFINITION  gamma-aminobutyric acid receptor subunit alpha-5 isoform X1 [Homo
            sapiens].
ACCESSION   XP_006720522
VERSION     XP_006720522.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720459.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..462
                     /product="gamma-aminobutyric acid receptor subunit alpha-5
                     isoform X1"
                     /calculated_mol_wt=52015
     Region          58..256
                     /region_name="LGIC_ECD_GABAAR_A5"
                     /note="extracellular domain of gamma-aminobutyric acid
                     receptor subunit alpha-5 (GABAAR-A5 or GABRA5); cd19038"
                     /db_xref="CDD:349839"
     Site            order(71,99)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:349839"
     Site            order(83,85..86,91..92,99,101..102,119,121..122,131..136,
                     139,141,143..144,150..152,154,164..166,194,256)
                     /site_type="other"
                     /note="pentamer interface [polypeptide binding]"
                     /db_xref="CDD:349839"
     Region          173..187
                     /region_name="Cys-loop"
                     /note="Cys-loop [structural motif]"
                     /db_xref="CDD:349839"
     Region          259..445
                     /region_name="LGIC_TM_GABAAR_alpha"
                     /note="transmembrane domain of alpha subunits of type-A
                     gamma-aminobutyric acid receptor (GABAAR); cd19052"
                     /db_xref="CDD:349854"
     Site            order(259,262..263,270..271,273..274,277,280..282,
                     285..288,290..292,294..295,298..299,305..306,308..309,
                     316..317,328,332,335,339,342..343,430)
                     /site_type="other"
                     /note="pentamer interface [polypeptide binding]"
                     /db_xref="CDD:349854"
     Region          259..282
                     /region_name="TM1 helix"
                     /note="TM1 helix [structural motif]"
                     /db_xref="CDD:349854"
     Site            order(273,276..277,280,336,339..340,434)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:349854"
     Region          286..310
                     /region_name="TM2 helix"
                     /note="TM2 helix [structural motif]"
                     /db_xref="CDD:349854"
     Region          318..344
                     /region_name="TM3 helix"
                     /note="TM3 helix [structural motif]"
                     /db_xref="CDD:349854"
     Region          421..445
                     /region_name="TM4 helix"
                     /note="TM4 helix [structural motif]"
                     /db_xref="CDD:349854"
     CDS             1..462
                     /gene="GABRA5"
                     /gene_synonym="DEE79; EIEE79"
                     /coded_by="XM_006720459.3:400..1788"
                     /db_xref="GeneID:2558"
                     /db_xref="HGNC:HGNC:4079"
                     /db_xref="MIM:137142"
ORIGIN      
        1 mdngmfsgfi miknlllfci smnlsshfgf sqmptssvkd etndnitift rildglldgy
       61 dnrlrpglge ritqvrtdiy vtsfgpvsdt emeytidvff rqswkderlr fkgpmqrlpl
      121 nnllaskiwt pdtffhngkk siahnmttpn kllrleddgt llytmrltis aecpmqledf
      181 pmdahacplk fgsyaypnse vvyvwtngst ksvvvaedgs rlnqyhlmgq tvgtenists
      241 tgeytimtah fhlkrkigyf viqtylpcim tvilsqvsfw lnresvpart vfgvttvltm
      301 ttlsisarns lpkvayatam dwfiavcyaf vfsaliefat vnyftkrgwa wdgkkaleaa
      361 kikkkrevil nkstnafttg kmshppnipk eqtpagtsnt tsvsvkpsee ktseskktyn
      421 siskidkmsr ivfpvlfgtf nlvywatyln repvikgaas pk
//
LOCUS       XP_047288294             306 aa            linear   PRI 05-AUG-2025
DEFINITION  gamma-aminobutyric acid receptor subunit alpha-5 isoform X2 [Homo
            sapiens].
ACCESSION   XP_047288294
VERSION     XP_047288294.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432338.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..306
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..306
                     /product="gamma-aminobutyric acid receptor subunit alpha-5
                     isoform X2"
                     /calculated_mol_wt=34713
     Region          58..256
                     /region_name="LGIC_ECD_GABAAR_A5"
                     /note="extracellular domain of gamma-aminobutyric acid
                     receptor subunit alpha-5 (GABAAR-A5 or GABRA5); cd19038"
                     /db_xref="CDD:349839"
     Site            order(71,99)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:349839"
     Site            order(83,85..86,91..92,99,101..102,119,121..122,131..136,
                     139,141,143..144,150..152,154,164..166,194,256)
                     /site_type="other"
                     /note="pentamer interface [polypeptide binding]"
                     /db_xref="CDD:349839"
     Region          173..187
                     /region_name="Cys-loop"
                     /note="Cys-loop [structural motif]"
                     /db_xref="CDD:349839"
     Region          259..>293
                     /region_name="LGIC_TM"
                     /note="transmembrane domain of Cys-loop
                     neurotransmitter-gated ion channels; cl38911"
                     /db_xref="CDD:476813"
     Region          262..282
                     /region_name="TM1 helix"
                     /note="TM1 helix [structural motif]"
                     /db_xref="CDD:349850"
     CDS             1..306
                     /gene="GABRA5"
                     /gene_synonym="DEE79; EIEE79"
                     /coded_by="XM_047432338.1:190..1110"
                     /db_xref="GeneID:2558"
                     /db_xref="HGNC:HGNC:4079"
                     /db_xref="MIM:137142"
ORIGIN      
        1 mdngmfsgfi miknlllfci smnlsshfgf sqmptssvkd etndnitift rildglldgy
       61 dnrlrpglge ritqvrtdiy vtsfgpvsdt emeytidvff rqswkderlr fkgpmqrlpl
      121 nnllaskiwt pdtffhngkk siahnmttpn kllrleddgt llytmrltis aecpmqledf
      181 pmdahacplk fgsyaypnse vvyvwtngst ksvvvaedgs rlnqyhlmgq tvgtenists
      241 tgeytimtah fhlkrkigyf viqtylpcim tvilsqvsfw lnresvpart vfgpldresv
      301 pdsiqt
//
LOCUS       XP_016877544             306 aa            linear   PRI 05-AUG-2025
DEFINITION  gamma-aminobutyric acid receptor subunit alpha-5 isoform X2 [Homo
            sapiens].
ACCESSION   XP_016877544
VERSION     XP_016877544.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022055.2
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 37% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..306
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..306
                     /product="gamma-aminobutyric acid receptor subunit alpha-5
                     isoform X2"
                     /calculated_mol_wt=34713
     Region          58..256
                     /region_name="LGIC_ECD_GABAAR_A5"
                     /note="extracellular domain of gamma-aminobutyric acid
                     receptor subunit alpha-5 (GABAAR-A5 or GABRA5); cd19038"
                     /db_xref="CDD:349839"
     Site            order(71,99)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:349839"
     Site            order(83,85..86,91..92,99,101..102,119,121..122,131..136,
                     139,141,143..144,150..152,154,164..166,194,256)
                     /site_type="other"
                     /note="pentamer interface [polypeptide binding]"
                     /db_xref="CDD:349839"
     Region          173..187
                     /region_name="Cys-loop"
                     /note="Cys-loop [structural motif]"
                     /db_xref="CDD:349839"
     Region          259..>293
                     /region_name="LGIC_TM"
                     /note="transmembrane domain of Cys-loop
                     neurotransmitter-gated ion channels; cl38911"
                     /db_xref="CDD:476813"
     Region          262..282
                     /region_name="TM1 helix"
                     /note="TM1 helix [structural motif]"
                     /db_xref="CDD:349850"
     CDS             1..306
                     /gene="GABRA5"
                     /gene_synonym="DEE79; EIEE79"
                     /coded_by="XM_017022055.2:806..1726"
                     /db_xref="GeneID:2558"
                     /db_xref="HGNC:HGNC:4079"
                     /db_xref="MIM:137142"
ORIGIN      
        1 mdngmfsgfi miknlllfci smnlsshfgf sqmptssvkd etndnitift rildglldgy
       61 dnrlrpglge ritqvrtdiy vtsfgpvsdt emeytidvff rqswkderlr fkgpmqrlpl
      121 nnllaskiwt pdtffhngkk siahnmttpn kllrleddgt llytmrltis aecpmqledf
      181 pmdahacplk fgsyaypnse vvyvwtngst ksvvvaedgs rlnqyhlmgq tvgtenists
      241 tgeytimtah fhlkrkigyf viqtylpcim tvilsqvsfw lnresvpart vfgpldresv
      301 pdsiqt
//
LOCUS       XP_047288295             306 aa            linear   PRI 05-AUG-2025
DEFINITION  gamma-aminobutyric acid receptor subunit alpha-5 isoform X2 [Homo
            sapiens].
ACCESSION   XP_047288295
VERSION     XP_047288295.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432339.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..306
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..306
                     /product="gamma-aminobutyric acid receptor subunit alpha-5
                     isoform X2"
                     /calculated_mol_wt=34713
     Region          58..256
                     /region_name="LGIC_ECD_GABAAR_A5"
                     /note="extracellular domain of gamma-aminobutyric acid
                     receptor subunit alpha-5 (GABAAR-A5 or GABRA5); cd19038"
                     /db_xref="CDD:349839"
     Site            order(71,99)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:349839"
     Site            order(83,85..86,91..92,99,101..102,119,121..122,131..136,
                     139,141,143..144,150..152,154,164..166,194,256)
                     /site_type="other"
                     /note="pentamer interface [polypeptide binding]"
                     /db_xref="CDD:349839"
     Region          173..187
                     /region_name="Cys-loop"
                     /note="Cys-loop [structural motif]"
                     /db_xref="CDD:349839"
     Region          259..>293
                     /region_name="LGIC_TM"
                     /note="transmembrane domain of Cys-loop
                     neurotransmitter-gated ion channels; cl38911"
                     /db_xref="CDD:476813"
     Region          262..282
                     /region_name="TM1 helix"
                     /note="TM1 helix [structural motif]"
                     /db_xref="CDD:349850"
     CDS             1..306
                     /gene="GABRA5"
                     /gene_synonym="DEE79; EIEE79"
                     /coded_by="XM_047432339.1:425..1345"
                     /db_xref="GeneID:2558"
                     /db_xref="HGNC:HGNC:4079"
                     /db_xref="MIM:137142"
ORIGIN      
        1 mdngmfsgfi miknlllfci smnlsshfgf sqmptssvkd etndnitift rildglldgy
       61 dnrlrpglge ritqvrtdiy vtsfgpvsdt emeytidvff rqswkderlr fkgpmqrlpl
      121 nnllaskiwt pdtffhngkk siahnmttpn kllrleddgt llytmrltis aecpmqledf
      181 pmdahacplk fgsyaypnse vvyvwtngst ksvvvaedgs rlnqyhlmgq tvgtenists
      241 tgeytimtah fhlkrkigyf viqtylpcim tvilsqvsfw lnresvpart vfgpldresv
      301 pdsiqt
//
LOCUS       XP_016877545             306 aa            linear   PRI 05-AUG-2025
DEFINITION  gamma-aminobutyric acid receptor subunit alpha-5 isoform X2 [Homo
            sapiens].
ACCESSION   XP_016877545
VERSION     XP_016877545.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022056.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..306
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..306
                     /product="gamma-aminobutyric acid receptor subunit alpha-5
                     isoform X2"
                     /calculated_mol_wt=34713
     Region          58..256
                     /region_name="LGIC_ECD_GABAAR_A5"
                     /note="extracellular domain of gamma-aminobutyric acid
                     receptor subunit alpha-5 (GABAAR-A5 or GABRA5); cd19038"
                     /db_xref="CDD:349839"
     Site            order(71,99)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:349839"
     Site            order(83,85..86,91..92,99,101..102,119,121..122,131..136,
                     139,141,143..144,150..152,154,164..166,194,256)
                     /site_type="other"
                     /note="pentamer interface [polypeptide binding]"
                     /db_xref="CDD:349839"
     Region          173..187
                     /region_name="Cys-loop"
                     /note="Cys-loop [structural motif]"
                     /db_xref="CDD:349839"
     Region          259..>293
                     /region_name="LGIC_TM"
                     /note="transmembrane domain of Cys-loop
                     neurotransmitter-gated ion channels; cl38911"
                     /db_xref="CDD:476813"
     Region          262..282
                     /region_name="TM1 helix"
                     /note="TM1 helix [structural motif]"
                     /db_xref="CDD:349850"
     CDS             1..306
                     /gene="GABRA5"
                     /gene_synonym="DEE79; EIEE79"
                     /coded_by="XM_017022056.2:396..1316"
                     /db_xref="GeneID:2558"
                     /db_xref="HGNC:HGNC:4079"
                     /db_xref="MIM:137142"
ORIGIN      
        1 mdngmfsgfi miknlllfci smnlsshfgf sqmptssvkd etndnitift rildglldgy
       61 dnrlrpglge ritqvrtdiy vtsfgpvsdt emeytidvff rqswkderlr fkgpmqrlpl
      121 nnllaskiwt pdtffhngkk siahnmttpn kllrleddgt llytmrltis aecpmqledf
      181 pmdahacplk fgsyaypnse vvyvwtngst ksvvvaedgs rlnqyhlmgq tvgtenists
      241 tgeytimtah fhlkrkigyf viqtylpcim tvilsqvsfw lnresvpart vfgpldresv
      301 pdsiqt
//
LOCUS       XP_011519730             414 aa            linear   PRI 05-AUG-2025
DEFINITION  gamma-aminobutyric acid receptor subunit beta-3 isoform X1 [Homo
            sapiens].
ACCESSION   XP_011519730
VERSION     XP_011519730.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521428.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..414
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..414
                     /product="gamma-aminobutyric acid receptor subunit beta-3
                     isoform X1"
                     /calculated_mol_wt=47714
     Region          22..412
                     /region_name="LIC"
                     /note="Cation transporter family protein; cl42365"
                     /db_xref="CDD:455710"
     CDS             1..414
                     /gene="GABRB3"
                     /gene_synonym="DEE43; ECA5; EIEE43"
                     /coded_by="XM_011521428.4:38..1282"
                     /db_xref="GeneID:2562"
                     /db_xref="HGNC:HGNC:4083"
                     /db_xref="MIM:137192"
ORIGIN      
        1 mqipslcdca llfgschiia kdytltmyfq qywrdkrlay sgiplnltld nrvadqlwvp
       61 dtyflndkks fvhgvtvknr mirlhpdgtv lyglrittta acmmdlrryp ldeqnctlei
      121 esygyttddi efywrggdka vtgverielp qfsivehrlv srnvvfatga yprlslsfrl
      181 krnigyfilq tympsiliti lswvsfwiny dasaarvalg ittvltmtti nthlretlpk
      241 ipyvkaidmy lmgcfvfvfl alleyafvny iffgrgpqrq kklaektaka kndrsksesn
      301 rvdahgnill tslevhnemn evsggigdtr nsaisfdnsg iqyrkqsmpr eghgrflgdr
      361 slphkkthlr rrssqlkiki pdltdvnaid rwsrivfpft fslfnlvywl yyvn
//
LOCUS       XP_047288296             138 aa            linear   PRI 05-AUG-2025
DEFINITION  lysM and putative peptidoglycan-binding domain-containing protein 2
            isoform X1 [Homo sapiens].
ACCESSION   XP_047288296
VERSION     XP_047288296.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432340.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..138
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..138
                     /product="lysM and putative peptidoglycan-binding
                     domain-containing protein 2 isoform X1"
                     /calculated_mol_wt=15394
     Region          <24..129
                     /region_name="Nup88"
                     /note="Nuclear pore component; pfam10168"
                     /db_xref="CDD:462975"
     CDS             1..138
                     /gene="LYSMD2"
                     /coded_by="XM_047432340.1:1224..1640"
                     /db_xref="GeneID:256586"
                     /db_xref="HGNC:HGNC:28571"
ORIGIN      
        1 mgrvldltqq palkmeqikr anklftndci flkktlnipv isekpllfng lnsidspene
       61 tadnsfsqee epvvagedlp ppspqesdvq pvqpeevsar dflqrldlqi klstqaakkl
      121 keesrdeesp yatslyhs
//
LOCUS       XP_047288297            1132 aa            linear   PRI 05-AUG-2025
DEFINITION  NUT family member 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047288297
VERSION     XP_047288297.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432341.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1132
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1132
                     /product="NUT family member 1 isoform X1"
                     /calculated_mol_wt=120184
     Region          14..>574
                     /region_name="NUT"
                     /note="NUT protein; pfam12881"
                     /db_xref="CDD:432850"
     Region          <907..1129
                     /region_name="NUT"
                     /note="NUT protein; pfam12881"
                     /db_xref="CDD:432850"
     CDS             1..1132
                     /gene="NUTM1"
                     /gene_synonym="C15orf55; FAM22H; NUT"
                     /coded_by="XM_047432341.1:555..3953"
                     /db_xref="GeneID:256646"
                     /db_xref="HGNC:HGNC:29919"
                     /db_xref="MIM:608963"
ORIGIN      
        1 masdgasalp gpdmsmkpsa apspspalpf lpptsdppdh pprepppqpi mpsvfspdnp
       61 lmlsafpssl lvtgdggpcl sgagagkviv kvkteggsae psqtqnfilt qtalnstapg
      121 tpcgglegpa ppfvtasnvk tilpskavgv sqegppglpp qppppvaqlv pivplekawp
      181 gphgttgegg pvatlskpsl gdrskiskdv yenfrqwqry kalarrhlsq spdtealscf
      241 lipvlrslar lkptmtleeg lplavqeweh tsnfdrmify emaerfmefe aeemqiqntq
      301 lmngsqglsp atplkldplg plasevcqqp vyipkkaask traprrrqrk aqrppapeap
      361 keippeavke yvdimewlvg thlatgesdg kqeeegqqqe eegmypdpgl lsyinelcsq
      421 kvfvskveav ihpqfladll spekqrdpla lieeleqeeg ltlaqlvqkr lmaleeeeda
      481 eappsfsgaq ldsspsgsve dedgdgrlrp spglqgagga aclgkvsssg krarevhggq
      541 eqaldsprgm hrdgntlpsp sswdlqpela apqgtpgplg verrgsgkvi nqvslhqdgh
      601 lggagppghc lvadrtseal plcwqggfqp estpsldagl aelaplqgqg lekqvlglqk
      661 gqqtggrgvl pqgkeplavp wegssgamwg ddrgtpmaqs ydqnpspraa gerddvclsp
      721 gvwlssemda vglelpvqie eviesfqvek cvteyqegcq glgsrgnisl gpgetlvpgd
      781 tessvipcgg tvaaaalekr nycslpgplr anspplrske nqeqscetvg hpsdlwaegc
      841 fpllesgdst lgssketlpp tcqgnllimg tedasslpea sqeagsrgns fsplletiep
      901 vnildvkddc glqlrvsedt cplnvhsydp qgegrvdpdl skpknlaplq esqesyttgt
      961 pkatsshqgl gstlprrgtr naivpretsv skthrsadra kgkekkkkea eeedeelsnf
     1021 ayllasklsl sprehplsph hasggqgsqr ashllpagak gpsklpypva ksgkralagg
     1081 paptektphs gaqlgvprek plalgvvrps qprkrrcdsf vtgrrkkrrr sq
//
LOCUS       XP_047288298            1102 aa            linear   PRI 05-AUG-2025
DEFINITION  WD repeat-containing protein 72 isoform X1 [Homo sapiens].
ACCESSION   XP_047288298
VERSION     XP_047288298.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432342.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1102
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1102
                     /product="WD repeat-containing protein 72 isoform X1"
                     /calculated_mol_wt=123295
     Region          13..>191
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          20..60
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          66..107
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          112..151
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          160..206
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          213..259
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          267..315
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          323..352
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          404..>595
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          407..459
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          465..502
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          512..554
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          561..596
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..1102
                     /gene="WDR72"
                     /gene_synonym="AI2A3"
                     /coded_by="XM_047432342.1:276..3584"
                     /db_xref="GeneID:256764"
                     /db_xref="HGNC:HGNC:26790"
                     /db_xref="MIM:613214"
ORIGIN      
        1 mrtslqaval wgqkapphsi taimitddqr tivtgsqegq lclwnlshel kisakellfg
       61 hsasvtclar ardfskqpyi vsaaengemc vwnvtngqcm ekatlpyrht aicyyhcsfr
      121 mtgegwllcc geyqdvliid aktlavvhsf rssqfpdwin cmcivhsmri qedsllvvsv
      181 agelkvwdls ssinsiqekq dvyekeskfl eslncqtirf ctyterlllv vfskcwkvyd
      241 ycdfslllte vsrngqffag geviaahril iwtedghsyi yqllnsglsk siypadgrvl
      301 ketiyphllc stsvqenkeq srpfvmgymn erkepfykvl fsgevsgrit lwhipdvpvs
      361 kfdgspreip vtatwtlqdn fdkhdtmsqs iidyfsglkd gagtavvtss eyipsldkli
      421 cgcedgtiii tqalnaakar lleggslvkd spphkvlkgh hqsvtsllyp hglsskldqs
      481 wmlsgdldsc vilwdiftee ilhkffleag pvtsllmspe kfklrgeqii ccvcgdhsva
      541 llhlegkscl lharkhlfpv rmikwhpven flivgcadds vyiweietgt lerhetgera
      601 riilnccdds qlvksvlpia setlkhksie qrssspyqlg plpcpglqve ssckvtdakf
      661 cprpfnvlpv ktkwsnvgfh illfdlenlv elllptplsd vdssssfygg evlrrakstv
      721 ekktltlrks ktacgplsae alakpitesl aqgdntikfs eendgikrqk kmkiskkmqp
      781 kpsrkvdasl tidtaklfls cllpwgvdkd ldylcikhln ilklqgpisl gislnednfs
      841 lmlpgwdlcn sgmikdysgv nlfsrkvldl sdkytatlpn qvgiprglen ncdslresdt
      901 ivyllsrlfl vnklvnmple lacrvgssfr mesihnkmrg agndilnmss fysclrngkn
      961 eshvpeadls llkliscwrd qsvqvteaiq avllaevqqh mkslgkipvn sqpvsmaeng
     1021 ncemkqmlpk lewteelelq cvrntlplqt pvspvkhdsn snsanfqdve dmpdrcalee
     1081 sespgeprhh swiakvcpck vs
//
LOCUS       XP_047288299            1102 aa            linear   PRI 05-AUG-2025
DEFINITION  WD repeat-containing protein 72 isoform X1 [Homo sapiens].
ACCESSION   XP_047288299
VERSION     XP_047288299.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432343.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1102
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1102
                     /product="WD repeat-containing protein 72 isoform X1"
                     /calculated_mol_wt=123295
     Region          13..>191
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          20..60
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          66..107
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          112..151
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          160..206
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          213..259
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          267..315
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          323..352
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          404..>595
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          407..459
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          465..502
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          512..554
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          561..596
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..1102
                     /gene="WDR72"
                     /gene_synonym="AI2A3"
                     /coded_by="XM_047432343.1:125..3433"
                     /db_xref="GeneID:256764"
                     /db_xref="HGNC:HGNC:26790"
                     /db_xref="MIM:613214"
ORIGIN      
        1 mrtslqaval wgqkapphsi taimitddqr tivtgsqegq lclwnlshel kisakellfg
       61 hsasvtclar ardfskqpyi vsaaengemc vwnvtngqcm ekatlpyrht aicyyhcsfr
      121 mtgegwllcc geyqdvliid aktlavvhsf rssqfpdwin cmcivhsmri qedsllvvsv
      181 agelkvwdls ssinsiqekq dvyekeskfl eslncqtirf ctyterlllv vfskcwkvyd
      241 ycdfslllte vsrngqffag geviaahril iwtedghsyi yqllnsglsk siypadgrvl
      301 ketiyphllc stsvqenkeq srpfvmgymn erkepfykvl fsgevsgrit lwhipdvpvs
      361 kfdgspreip vtatwtlqdn fdkhdtmsqs iidyfsglkd gagtavvtss eyipsldkli
      421 cgcedgtiii tqalnaakar lleggslvkd spphkvlkgh hqsvtsllyp hglsskldqs
      481 wmlsgdldsc vilwdiftee ilhkffleag pvtsllmspe kfklrgeqii ccvcgdhsva
      541 llhlegkscl lharkhlfpv rmikwhpven flivgcadds vyiweietgt lerhetgera
      601 riilnccdds qlvksvlpia setlkhksie qrssspyqlg plpcpglqve ssckvtdakf
      661 cprpfnvlpv ktkwsnvgfh illfdlenlv elllptplsd vdssssfygg evlrrakstv
      721 ekktltlrks ktacgplsae alakpitesl aqgdntikfs eendgikrqk kmkiskkmqp
      781 kpsrkvdasl tidtaklfls cllpwgvdkd ldylcikhln ilklqgpisl gislnednfs
      841 lmlpgwdlcn sgmikdysgv nlfsrkvldl sdkytatlpn qvgiprglen ncdslresdt
      901 ivyllsrlfl vnklvnmple lacrvgssfr mesihnkmrg agndilnmss fysclrngkn
      961 eshvpeadls llkliscwrd qsvqvteaiq avllaevqqh mkslgkipvn sqpvsmaeng
     1021 ncemkqmlpk lewteelelq cvrntlplqt pvspvkhdsn snsanfqdve dmpdrcalee
     1081 sespgeprhh swiakvcpck vs
//
LOCUS       XP_047288300            1102 aa            linear   PRI 05-AUG-2025
DEFINITION  WD repeat-containing protein 72 isoform X1 [Homo sapiens].
ACCESSION   XP_047288300
VERSION     XP_047288300.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432344.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1102
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1102
                     /product="WD repeat-containing protein 72 isoform X1"
                     /calculated_mol_wt=123295
     Region          13..>191
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          20..60
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          66..107
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          112..151
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          160..206
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          213..259
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          267..315
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          323..352
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          404..>595
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          407..459
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          465..502
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          512..554
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          561..596
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..1102
                     /gene="WDR72"
                     /gene_synonym="AI2A3"
                     /coded_by="XM_047432344.1:195..3503"
                     /db_xref="GeneID:256764"
                     /db_xref="HGNC:HGNC:26790"
                     /db_xref="MIM:613214"
ORIGIN      
        1 mrtslqaval wgqkapphsi taimitddqr tivtgsqegq lclwnlshel kisakellfg
       61 hsasvtclar ardfskqpyi vsaaengemc vwnvtngqcm ekatlpyrht aicyyhcsfr
      121 mtgegwllcc geyqdvliid aktlavvhsf rssqfpdwin cmcivhsmri qedsllvvsv
      181 agelkvwdls ssinsiqekq dvyekeskfl eslncqtirf ctyterlllv vfskcwkvyd
      241 ycdfslllte vsrngqffag geviaahril iwtedghsyi yqllnsglsk siypadgrvl
      301 ketiyphllc stsvqenkeq srpfvmgymn erkepfykvl fsgevsgrit lwhipdvpvs
      361 kfdgspreip vtatwtlqdn fdkhdtmsqs iidyfsglkd gagtavvtss eyipsldkli
      421 cgcedgtiii tqalnaakar lleggslvkd spphkvlkgh hqsvtsllyp hglsskldqs
      481 wmlsgdldsc vilwdiftee ilhkffleag pvtsllmspe kfklrgeqii ccvcgdhsva
      541 llhlegkscl lharkhlfpv rmikwhpven flivgcadds vyiweietgt lerhetgera
      601 riilnccdds qlvksvlpia setlkhksie qrssspyqlg plpcpglqve ssckvtdakf
      661 cprpfnvlpv ktkwsnvgfh illfdlenlv elllptplsd vdssssfygg evlrrakstv
      721 ekktltlrks ktacgplsae alakpitesl aqgdntikfs eendgikrqk kmkiskkmqp
      781 kpsrkvdasl tidtaklfls cllpwgvdkd ldylcikhln ilklqgpisl gislnednfs
      841 lmlpgwdlcn sgmikdysgv nlfsrkvldl sdkytatlpn qvgiprglen ncdslresdt
      901 ivyllsrlfl vnklvnmple lacrvgssfr mesihnkmrg agndilnmss fysclrngkn
      961 eshvpeadls llkliscwrd qsvqvteaiq avllaevqqh mkslgkipvn sqpvsmaeng
     1021 ncemkqmlpk lewteelelq cvrntlplqt pvspvkhdsn snsanfqdve dmpdrcalee
     1081 sespgeprhh swiakvcpck vs
//
LOCUS       XP_016877550            1102 aa            linear   PRI 05-AUG-2025
DEFINITION  WD repeat-containing protein 72 isoform X1 [Homo sapiens].
ACCESSION   XP_016877550
VERSION     XP_016877550.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022061.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1102
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1102
                     /product="WD repeat-containing protein 72 isoform X1"
                     /calculated_mol_wt=123295
     Region          13..>191
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          20..60
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          66..107
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          112..151
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          160..206
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          213..259
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          267..315
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          323..352
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          404..>595
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          407..459
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          465..502
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          512..554
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          561..596
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..1102
                     /gene="WDR72"
                     /gene_synonym="AI2A3"
                     /coded_by="XM_017022061.2:202..3510"
                     /db_xref="GeneID:256764"
                     /db_xref="HGNC:HGNC:26790"
                     /db_xref="MIM:613214"
ORIGIN      
        1 mrtslqaval wgqkapphsi taimitddqr tivtgsqegq lclwnlshel kisakellfg
       61 hsasvtclar ardfskqpyi vsaaengemc vwnvtngqcm ekatlpyrht aicyyhcsfr
      121 mtgegwllcc geyqdvliid aktlavvhsf rssqfpdwin cmcivhsmri qedsllvvsv
      181 agelkvwdls ssinsiqekq dvyekeskfl eslncqtirf ctyterlllv vfskcwkvyd
      241 ycdfslllte vsrngqffag geviaahril iwtedghsyi yqllnsglsk siypadgrvl
      301 ketiyphllc stsvqenkeq srpfvmgymn erkepfykvl fsgevsgrit lwhipdvpvs
      361 kfdgspreip vtatwtlqdn fdkhdtmsqs iidyfsglkd gagtavvtss eyipsldkli
      421 cgcedgtiii tqalnaakar lleggslvkd spphkvlkgh hqsvtsllyp hglsskldqs
      481 wmlsgdldsc vilwdiftee ilhkffleag pvtsllmspe kfklrgeqii ccvcgdhsva
      541 llhlegkscl lharkhlfpv rmikwhpven flivgcadds vyiweietgt lerhetgera
      601 riilnccdds qlvksvlpia setlkhksie qrssspyqlg plpcpglqve ssckvtdakf
      661 cprpfnvlpv ktkwsnvgfh illfdlenlv elllptplsd vdssssfygg evlrrakstv
      721 ekktltlrks ktacgplsae alakpitesl aqgdntikfs eendgikrqk kmkiskkmqp
      781 kpsrkvdasl tidtaklfls cllpwgvdkd ldylcikhln ilklqgpisl gislnednfs
      841 lmlpgwdlcn sgmikdysgv nlfsrkvldl sdkytatlpn qvgiprglen ncdslresdt
      901 ivyllsrlfl vnklvnmple lacrvgssfr mesihnkmrg agndilnmss fysclrngkn
      961 eshvpeadls llkliscwrd qsvqvteaiq avllaevqqh mkslgkipvn sqpvsmaeng
     1021 ncemkqmlpk lewteelelq cvrntlplqt pvspvkhdsn snsanfqdve dmpdrcalee
     1081 sespgeprhh swiakvcpck vs
//
LOCUS       XP_011519738            1096 aa            linear   PRI 05-AUG-2025
DEFINITION  WD repeat-containing protein 72 isoform X2 [Homo sapiens].
ACCESSION   XP_011519738
VERSION     XP_011519738.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521436.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1096
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1096
                     /product="WD repeat-containing protein 72 isoform X2"
                     /calculated_mol_wt=122753
     Region          13..>191
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          20..60
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          66..107
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          112..151
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          160..206
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          213..259
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          267..315
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          323..352
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          404..>589
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          407..453
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          459..496
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          506..548
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          555..590
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..1096
                     /gene="WDR72"
                     /gene_synonym="AI2A3"
                     /coded_by="XM_011521436.3:44..3334"
                     /db_xref="GeneID:256764"
                     /db_xref="HGNC:HGNC:26790"
                     /db_xref="MIM:613214"
ORIGIN      
        1 mrtslqaval wgqkapphsi taimitddqr tivtgsqegq lclwnlshel kisakellfg
       61 hsasvtclar ardfskqpyi vsaaengemc vwnvtngqcm ekatlpyrht aicyyhcsfr
      121 mtgegwllcc geyqdvliid aktlavvhsf rssqfpdwin cmcivhsmri qedsllvvsv
      181 agelkvwdls ssinsiqekq dvyekeskfl eslncqtirf ctyterlllv vfskcwkvyd
      241 ycdfslllte vsrngqffag geviaahril iwtedghsyi yqllnsglsk siypadgrvl
      301 ketiyphllc stsvqenkeq srpfvmgymn erkepfykvl fsgevsgrit lwhipdvpvs
      361 kfdgspreip vtatwtlqdn fdkhdtmsqs iidyfsglkd gagtavvtss eyipsldkli
      421 cgcedgtiii tqalnaakar lledspphkv lkghhqsvts llyphglssk ldqswmlsgd
      481 ldscvilwdi fteeilhkff leagpvtsll mspekfklrg eqiiccvcgd hsvallhleg
      541 kscllharkh lfpvrmikwh pvenflivgc addsvyiwei etgtlerhet gerariilnc
      601 cddsqlvksv lpiasetlkh ksieqrsssp yqlgplpcpg lqvessckvt dakfcprpfn
      661 vlpvktkwsn vgfhillfdl enlvelllpt plsdvdssss fyggevlrra kstvekktlt
      721 lrksktacgp lsaealakpi teslaqgdnt ikfseendgi krqkkmkisk kmqpkpsrkv
      781 dasltidtak lflscllpwg vdkdldylci khlnilklqg pislgislne dnfslmlpgw
      841 dlcnsgmikd ysgvnlfsrk vldlsdkyta tlpnqvgipr glenncdslr esdtivylls
      901 rlflvnklvn mplelacrvg ssfrmesihn kmrgagndil nmssfysclr ngkneshvpe
      961 adlsllklis cwrdqsvqvt eaiqavllae vqqhmkslgk ipvnsqpvsm aengncemkq
     1021 mlpklewtee lelqcvrntl plqtpvspvk hdsnsnsanf qdvedmpdrc aleesespge
     1081 prhhswiakv cpckvs
//
LOCUS       XP_047288301            1062 aa            linear   PRI 05-AUG-2025
DEFINITION  WD repeat-containing protein 72 isoform X3 [Homo sapiens].
ACCESSION   XP_047288301
VERSION     XP_047288301.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432345.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1062
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1062
                     /product="WD repeat-containing protein 72 isoform X3"
                     /calculated_mol_wt=118406
     Region          13..259
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          20..60
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          66..107
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          112..151
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          160..199
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          206..235
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          240..275
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          283..312
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          364..>555
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          367..419
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          425..462
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          472..514
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          521..556
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..1062
                     /gene="WDR72"
                     /gene_synonym="AI2A3"
                     /coded_by="XM_047432345.1:276..3464"
                     /db_xref="GeneID:256764"
                     /db_xref="HGNC:HGNC:26790"
                     /db_xref="MIM:613214"
ORIGIN      
        1 mrtslqaval wgqkapphsi taimitddqr tivtgsqegq lclwnlshel kisakellfg
       61 hsasvtclar ardfskqpyi vsaaengemc vwnvtngqcm ekatlpyrht aicyyhcsfr
      121 mtgegwllcc geyqdvliid aktlavvhsf rssqfpdwin cmcivhsmri qedsllvvsv
      181 agelkvwdls ssinsiqvyd ycdfslllte vsrngqffag geviaahril iwtedghsyi
      241 yqllnsglsk siypadgrvl ketiyphllc stsvqenkeq srpfvmgymn erkepfykvl
      301 fsgevsgrit lwhipdvpvs kfdgspreip vtatwtlqdn fdkhdtmsqs iidyfsglkd
      361 gagtavvtss eyipsldkli cgcedgtiii tqalnaakar lleggslvkd spphkvlkgh
      421 hqsvtsllyp hglsskldqs wmlsgdldsc vilwdiftee ilhkffleag pvtsllmspe
      481 kfklrgeqii ccvcgdhsva llhlegkscl lharkhlfpv rmikwhpven flivgcadds
      541 vyiweietgt lerhetgera riilnccdds qlvksvlpia setlkhksie qrssspyqlg
      601 plpcpglqve ssckvtdakf cprpfnvlpv ktkwsnvgfh illfdlenlv elllptplsd
      661 vdssssfygg evlrrakstv ekktltlrks ktacgplsae alakpitesl aqgdntikfs
      721 eendgikrqk kmkiskkmqp kpsrkvdasl tidtaklfls cllpwgvdkd ldylcikhln
      781 ilklqgpisl gislnednfs lmlpgwdlcn sgmikdysgv nlfsrkvldl sdkytatlpn
      841 qvgiprglen ncdslresdt ivyllsrlfl vnklvnmple lacrvgssfr mesihnkmrg
      901 agndilnmss fysclrngkn eshvpeadls llkliscwrd qsvqvteaiq avllaevqqh
      961 mkslgkipvn sqpvsmaeng ncemkqmlpk lewteelelq cvrntlplqt pvspvkhdsn
     1021 snsanfqdve dmpdrcalee sespgeprhh swiakvcpck vs
//
LOCUS       XP_047288303             477 aa            linear   PRI 05-AUG-2025
DEFINITION  N-acetylgalactosamine kinase isoform X1 [Homo sapiens].
ACCESSION   XP_047288303
VERSION     XP_047288303.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432347.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..477
                     /product="N-acetylgalactosamine kinase isoform X1"
                     /calculated_mol_wt=52575
     Region          2..466
                     /region_name="PLN02521"
                     /note="galactokinase"
                     /db_xref="CDD:215285"
     CDS             1..477
                     /gene="GALK2"
                     /gene_synonym="GK2"
                     /coded_by="XM_047432347.1:363..1796"
                     /db_xref="GeneID:2585"
                     /db_xref="HGNC:HGNC:4119"
                     /db_xref="MIM:137028"
ORIGIN      
        1 mfnskfgsip kfyvrapgrv niigehidyc gysvlpmave qdvliavepv ktyalqlant
       61 nplypdfsts anniqidktk plwhnyflcg lkgiqehfgl snltgmnclv dgnippssgl
      121 ssssalvcca glvtltvlgr nlskvelaei cakseryigt egggmdqsis flaeegtakl
      181 iefsplratd vklpsgavfv ianscvemnk aatshfnirv mecrlaakll akykslqwdk
      241 vlrleevqak lgisleemll vtedalhpep ynpeeicrcl gisleelrtq ilspntqdgi
      301 ilhipqccde nfmrfkqfsh fslsnswdym hppsscpvli fklyqrakhv yseaarvlqf
      361 kkiceeapen mvqllgelmn qshmscrdmy ecscpeldql vdicrkfgaq gsrltgagwg
      421 gctvsmvpad klpsflanvh kayyqrsdgs lapekqslfa tkpggaleip asscilr
//
LOCUS       XP_047288304             477 aa            linear   PRI 05-AUG-2025
DEFINITION  N-acetylgalactosamine kinase isoform X1 [Homo sapiens].
ACCESSION   XP_047288304
VERSION     XP_047288304.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432348.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 5% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..477
                     /product="N-acetylgalactosamine kinase isoform X1"
                     /calculated_mol_wt=52575
     Region          2..466
                     /region_name="PLN02521"
                     /note="galactokinase"
                     /db_xref="CDD:215285"
     CDS             1..477
                     /gene="GALK2"
                     /gene_synonym="GK2"
                     /coded_by="XM_047432348.1:150..1583"
                     /db_xref="GeneID:2585"
                     /db_xref="HGNC:HGNC:4119"
                     /db_xref="MIM:137028"
ORIGIN      
        1 mfnskfgsip kfyvrapgrv niigehidyc gysvlpmave qdvliavepv ktyalqlant
       61 nplypdfsts anniqidktk plwhnyflcg lkgiqehfgl snltgmnclv dgnippssgl
      121 ssssalvcca glvtltvlgr nlskvelaei cakseryigt egggmdqsis flaeegtakl
      181 iefsplratd vklpsgavfv ianscvemnk aatshfnirv mecrlaakll akykslqwdk
      241 vlrleevqak lgisleemll vtedalhpep ynpeeicrcl gisleelrtq ilspntqdgi
      301 ilhipqccde nfmrfkqfsh fslsnswdym hppsscpvli fklyqrakhv yseaarvlqf
      361 kkiceeapen mvqllgelmn qshmscrdmy ecscpeldql vdicrkfgaq gsrltgagwg
      421 gctvsmvpad klpsflanvh kayyqrsdgs lapekqslfa tkpggaleip asscilr
//
LOCUS       XP_006720524             458 aa            linear   PRI 05-AUG-2025
DEFINITION  N-acetylgalactosamine kinase isoform X2 [Homo sapiens].
ACCESSION   XP_006720524
VERSION     XP_006720524.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720461.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..458
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..458
                     /product="N-acetylgalactosamine kinase isoform X2"
                     /calculated_mol_wt=50488
     Region          18..448
                     /region_name="PLN02521"
                     /note="galactokinase"
                     /db_xref="CDD:215285"
     CDS             1..458
                     /gene="GALK2"
                     /gene_synonym="GK2"
                     /coded_by="XM_006720461.5:77..1453"
                     /db_xref="GeneID:2585"
                     /db_xref="HGNC:HGNC:4119"
                     /db_xref="MIM:137028"
ORIGIN      
        1 matespatrr vqvaehprll klkemfnskf gsipkfyvra pgrvniigeh idycgysvlp
       61 maveqdvlia vepvktyalq lantnplypd fstsanniqi dktkplwhny flcglkgiqe
      121 hfglsnltgm nclvdgnipp ssglssssal vccaglvtlt vlgrnlskve laeicakser
      181 yigtegggmd qsisflaeeg takliefspl ratdvklpsg avfvianscv emnkaatshf
      241 nirvmecrla akllakyksl qwdkvlrlee vqaklgisle emllvtedal hpepynpeei
      301 crclgislee lrtqilspnt qdvlifklyq rakhvyseaa rvlqfkkice eapenmvqll
      361 gelmnqshms crdmyecscp eldqlvdicr kfgaqgsrlt gagwggctvs mvpadklpsf
      421 lanvhkayyq rsdgslapek qslfatkpga seryennt
//
LOCUS       XP_047288305             447 aa            linear   PRI 05-AUG-2025
DEFINITION  N-acetylgalactosamine kinase isoform X3 [Homo sapiens].
ACCESSION   XP_047288305
VERSION     XP_047288305.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432349.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..447
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..447
                     /product="N-acetylgalactosamine kinase isoform X3"
                     /calculated_mol_wt=49345
     Region          7..437
                     /region_name="PLN02521"
                     /note="galactokinase"
                     /db_xref="CDD:215285"
     CDS             1..447
                     /gene="GALK2"
                     /gene_synonym="GK2"
                     /coded_by="XM_047432349.1:224..1567"
                     /db_xref="GeneID:2585"
                     /db_xref="HGNC:HGNC:4119"
                     /db_xref="MIM:137028"
ORIGIN      
        1 mpvlydrllk lkemfnskfg sipkfyvrap grvniigehi dycgysvlpm aveqdvliav
       61 epvktyalql antnplypdf stsanniqid ktkplwhnyf lcglkgiqeh fglsnltgmn
      121 clvdgnipps sglssssalv ccaglvtltv lgrnlskvel aeicaksery igtegggmdq
      181 sisflaeegt akliefsplr atdvklpsga vfvianscve mnkaatshfn irvmecrlaa
      241 kllakykslq wdkvlrleev qaklgislee mllvtedalh pepynpeeic rclgisleel
      301 rtqilspntq dvlifklyqr akhvyseaar vlqfkkicee apenmvqllg elmnqshmsc
      361 rdmyecscpe ldqlvdicrk fgaqgsrltg agwggctvsm vpadklpsfl anvhkayyqr
      421 sdgslapekq slfatkpgas eryennt
//
LOCUS       XP_024305660             438 aa            linear   PRI 05-AUG-2025
DEFINITION  N-acetylgalactosamine kinase isoform X4 [Homo sapiens].
ACCESSION   XP_024305660
VERSION     XP_024305660.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449892.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..438
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..438
                     /product="N-acetylgalactosamine kinase isoform X4"
                     /calculated_mol_wt=47992
     Region          2..427
                     /region_name="PLN02521"
                     /note="galactokinase"
                     /db_xref="CDD:215285"
     CDS             1..438
                     /gene="GALK2"
                     /gene_synonym="GK2"
                     /coded_by="XM_024449892.2:363..1679"
                     /db_xref="GeneID:2585"
                     /db_xref="HGNC:HGNC:4119"
                     /db_xref="MIM:137028"
ORIGIN      
        1 mfnskfgsip kfyvrapgrv niigehidyc gysvlpmave qdvliavepv ktyalqlant
       61 nplypdfsts anniqidktk plwhnyflcg lkgiqehfgl snltgmnclv dgnippssgl
      121 ssssalvcca glvtltvlgr nlskvelaei cakseryigt egggmdqsis flaeegtakl
      181 iefsplratd vklpsgavfv ianscvemnk aatshfnirv mecrlaakll akykslqwdk
      241 vlrleevqak lgisleemll vtedalhpep ynpeeicrcl gisleelrtq ilspntqdvl
      301 ifklyqrakh vyseaarvlq fkkiceeape nmvqllgelm nqshmscrdm yecscpeldq
      361 lvdicrkfga qgsrltgagw ggctvsmvpa dklpsflanv hkayyqrsdg slapekqslf
      421 atkpggalei passcilr
//
LOCUS       XP_047288306             434 aa            linear   PRI 05-AUG-2025
DEFINITION  N-acetylgalactosamine kinase isoform X5 [Homo sapiens].
ACCESSION   XP_047288306
VERSION     XP_047288306.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432350.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..434
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..434
                     /product="N-acetylgalactosamine kinase isoform X5"
                     /calculated_mol_wt=47745
     Region          2..424
                     /region_name="PLN02521"
                     /note="galactokinase"
                     /db_xref="CDD:215285"
     CDS             1..434
                     /gene="GALK2"
                     /gene_synonym="GK2"
                     /coded_by="XM_047432350.1:363..1667"
                     /db_xref="GeneID:2585"
                     /db_xref="HGNC:HGNC:4119"
                     /db_xref="MIM:137028"
ORIGIN      
        1 mfnskfgsip kfyvrapgrv niigehidyc gysvlpmave qdvliavepv ktyalqlant
       61 nplypdfsts anniqidktk plwhnyflcg lkgiqehfgl snltgmnclv dgnippssgl
      121 ssssalvcca glvtltvlgr nlskvelaei cakseryigt egggmdqsis flaeegtakl
      181 iefsplratd vklpsgavfv ianscvemnk aatshfnirv mecrlaakll akykslqwdk
      241 vlrleevqak lgisleemll vtedalhpep ynpeeicrcl gisleelrtq ilspntqdvl
      301 ifklyqrakh vyseaarvlq fkkiceeape nmvqllgelm nqshmscrdm yecscpeldq
      361 lvdicrkfga qgsrltgagw ggctvsmvpa dklpsflanv hkayyqrsdg slapekqslf
      421 atkpgasery ennt
//
LOCUS       XP_024305662             405 aa            linear   PRI 05-AUG-2025
DEFINITION  N-acetylgalactosamine kinase isoform X6 [Homo sapiens].
ACCESSION   XP_024305662
VERSION     XP_024305662.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449894.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..405
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..405
                     /product="N-acetylgalactosamine kinase isoform X6"
                     /calculated_mol_wt=44518
     Region          2..394
                     /region_name="PLN02521"
                     /note="galactokinase"
                     /db_xref="CDD:215285"
     CDS             1..405
                     /gene="GALK2"
                     /gene_synonym="GK2"
                     /coded_by="XM_024449894.2:363..1580"
                     /db_xref="GeneID:2585"
                     /db_xref="HGNC:HGNC:4119"
                     /db_xref="MIM:137028"
ORIGIN      
        1 mfnskfgsip kfyvrapgrv niigehidyc gysvlpmave qdvliavepv ktyalqlant
       61 nplypdfsts anniqidktk plwhnyflcg lkgiqehfgl snltgmnclv dgnippssgl
      121 ssssalvcca glvtltvlgr nlskaklief splratdvkl psgavfvian scvemnkaat
      181 shfnirvmec rlaakllaky kslqwdkvlr leevqaklgi sleemllvte dalhpepynp
      241 eeicrclgis leelrtqils pntqdvlifk lyqrakhvys eaarvlqfkk iceeapenmv
      301 qllgelmnqs hmscrdmyec scpeldqlvd icrkfgaqgs rltgagwggc tvsmvpadkl
      361 psflanvhka yyqrsdgsla pekqslfatk pggaleipas scilr
//
LOCUS       XP_047288307             372 aa            linear   PRI 05-AUG-2025
DEFINITION  N-acetylgalactosamine kinase isoform X7 [Homo sapiens].
ACCESSION   XP_047288307
VERSION     XP_047288307.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432351.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..372
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..372
                     /product="N-acetylgalactosamine kinase isoform X7"
                     /calculated_mol_wt=40841
     Region          <1..361
                     /region_name="PLN02521"
                     /note="galactokinase"
                     /db_xref="CDD:215285"
     CDS             1..372
                     /gene="GALK2"
                     /gene_synonym="GK2"
                     /coded_by="XM_047432351.1:355..1473"
                     /db_xref="GeneID:2585"
                     /db_xref="HGNC:HGNC:4119"
                     /db_xref="MIM:137028"
ORIGIN      
        1 mnclvdgnip pssglssssa lvccaglvtl tvlgrnlskv elaeicakse ryigtegggm
       61 dqsisflaee gtakliefsp lratdvklps gavfviansc vemnkaatsh fnirvmecrl
      121 aakllakyks lqwdkvlrle evqaklgisl eemllvteda lhpepynpee icrclgisle
      181 elrtqilspn tqdgiilhip qccdenfmrf kqfshfslsn swdymhppss cpvlifklyq
      241 rakhvyseaa rvlqfkkice eapenmvqll gelmnqshms crdmyecscp eldqlvdicr
      301 kfgaqgsrlt gagwggctvs mvpadklpsf lanvhkayyq rsdgslapek qslfatkpgg
      361 aleipassci lr
//
LOCUS       XP_047288308             372 aa            linear   PRI 05-AUG-2025
DEFINITION  N-acetylgalactosamine kinase isoform X7 [Homo sapiens].
ACCESSION   XP_047288308
VERSION     XP_047288308.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432352.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..372
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..372
                     /product="N-acetylgalactosamine kinase isoform X7"
                     /calculated_mol_wt=40841
     Region          <1..361
                     /region_name="PLN02521"
                     /note="galactokinase"
                     /db_xref="CDD:215285"
     CDS             1..372
                     /gene="GALK2"
                     /gene_synonym="GK2"
                     /coded_by="XM_047432352.1:6842..7960"
                     /db_xref="GeneID:2585"
                     /db_xref="HGNC:HGNC:4119"
                     /db_xref="MIM:137028"
ORIGIN      
        1 mnclvdgnip pssglssssa lvccaglvtl tvlgrnlskv elaeicakse ryigtegggm
       61 dqsisflaee gtakliefsp lratdvklps gavfviansc vemnkaatsh fnirvmecrl
      121 aakllakyks lqwdkvlrle evqaklgisl eemllvteda lhpepynpee icrclgisle
      181 elrtqilspn tqdgiilhip qccdenfmrf kqfshfslsn swdymhppss cpvlifklyq
      241 rakhvyseaa rvlqfkkice eapenmvqll gelmnqshms crdmyecscp eldqlvdicr
      301 kfgaqgsrlt gagwggctvs mvpadklpsf lanvhkayyq rsdgslapek qslfatkpgg
      361 aleipassci lr
//
LOCUS       XP_047288309             350 aa            linear   PRI 05-AUG-2025
DEFINITION  N-acetylgalactosamine kinase isoform X8 [Homo sapiens].
ACCESSION   XP_047288309
VERSION     XP_047288309.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432353.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..350
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..350
                     /product="N-acetylgalactosamine kinase isoform X8"
                     /calculated_mol_wt=38499
     Region          2..347
                     /region_name="PLN02521"
                     /note="galactokinase"
                     /db_xref="CDD:215285"
     CDS             1..350
                     /gene="GALK2"
                     /gene_synonym="GK2"
                     /coded_by="XM_047432353.1:363..1415"
                     /db_xref="GeneID:2585"
                     /db_xref="HGNC:HGNC:4119"
                     /db_xref="MIM:137028"
ORIGIN      
        1 mfnskfgsip kfyvrapgrv niigehidyc gysvlpmave qdvliavepv ktyalqlant
       61 nplypdfsts anniqidktk plwhnyflcg lkgiqehfgl snltgmnclv dgnippssgl
      121 ssssalvcca glvtltvlgr nlskllakyk slqwdkvlrl eevqaklgis leemllvted
      181 alhpepynpe eicrclgisl eelrtqilsp ntqdvlifkl yqrakhvyse aarvlqfkki
      241 ceeapenmvq llgelmnqsh mscrdmyecs cpeldqlvdi crkfgaqgsr ltgagwggct
      301 vsmvpadklp sflanvhkay yqrsdgslap ekqslfatkp gggalvllea
//
LOCUS       XP_047288310             300 aa            linear   PRI 05-AUG-2025
DEFINITION  N-acetylgalactosamine kinase isoform X9 [Homo sapiens].
ACCESSION   XP_047288310
VERSION     XP_047288310.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432354.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..300
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..300
                     /product="N-acetylgalactosamine kinase isoform X9"
                     /calculated_mol_wt=32819
     Region          2..>299
                     /region_name="PLN02521"
                     /note="galactokinase"
                     /db_xref="CDD:215285"
     CDS             1..300
                     /gene="GALK2"
                     /gene_synonym="GK2"
                     /coded_by="XM_047432354.1:363..1265"
                     /db_xref="GeneID:2585"
                     /db_xref="HGNC:HGNC:4119"
                     /db_xref="MIM:137028"
ORIGIN      
        1 mfnskfgsip kfyvrapgrv niigehidyc gysvlpmave qdvliavepv ktyalqlant
       61 nplypdfsts anniqidktk plwhnyflcg lkgiqehfgl snltgmnclv dgnippssgl
      121 ssssalvcca glvtltvlgr nlskvelaei cakseryigt egggmdqsis flaeegtakl
      181 iefsplratd vklpsgavfv ianscvemnk aatshfnirv mecrlaakll akykslqwdk
      241 vlrleevqak lgisleemll vtedalhpep ynpeeicrcl gisleelrtq ilspntqdvw
//
LOCUS       XP_047288311            1273 aa            linear   PRI 05-AUG-2025
DEFINITION  paired amphipathic helix protein Sin3a isoform X1 [Homo sapiens].
ACCESSION   XP_047288311
VERSION     XP_047288311.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432355.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1273
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1273
                     /product="paired amphipathic helix protein Sin3a isoform
                     X1"
                     /calculated_mol_wt=145045
     Region          5..1213
                     /region_name="Sin3"
                     /note="Histone deacetylase complex, regulatory component
                     SIN3 [Chromatin structure and dynamics]; COG5602"
                     /db_xref="CDD:227889"
     CDS             1..1273
                     /gene="SIN3A"
                     /gene_synonym="CHR15DELq24; DEL15Q24; WITKOS"
                     /coded_by="XM_047432355.1:465..4286"
                     /db_xref="GeneID:25942"
                     /db_xref="HGNC:HGNC:19353"
                     /db_xref="MIM:607776"
ORIGIN      
        1 mkrrlddqes pvyaaqqrri pgsteafphq hrvlapappv yeavsetmqs atgiqysvtp
       61 syqvsampqs sgshgpaiaa vhsshhhpta vqphggqvvq shahpappva pvqgqqqfqr
      121 lkvedalsyl dqvklqfgsq pqvyndfldi mkefksqsid tpgvisrvsq lfkghpdlim
      181 gfntflppgy kievqtndmv nvttpgqvhq ipthgiqpqp qpppqhpsqp saqsapapaq
      241 papqpppakv skpsqlqaht pasqqtpplp pyasprsppv qphtpvtisl gtapslqnnq
      301 pvefnhainy vnkiknrfqg qpdiykafle ilhtyqkeqr nakeaggnyt palteqevya
      361 qvarlfknqe dllsefgqfl pdanssvlls kttaekvdsv rndhggtvkk pqlnnkpqrp
      421 sqngcqirrh ptgttppvkk kpkllnlkds smadaskhgg gteslffdkv rkalrsaeay
      481 enflrclvif nqevisrael vqlvspflgk fpelfnwfkn flgykesvhl etypkerate
      541 giameidyas ckrlgssyra lpksyqqpkc tgrtplckev lndtwvsfps wsedstfvss
      601 kktqyeehiy rcederfeld vvletnlati rvleaiqkkl srlsaeeqak frldntlggt
      661 sevihrkalq riyadkaadi idglrknpsi avpivlkrlk mkeeewreaq rgfnkvwreq
      721 nekyylksld hqginfkqnd tkvlrsksll neiesiyder qeqateenag vpvgphlsla
      781 yedkqileda aaliihhvkr qtgiqkedky kikqimhhfi pdllfaqrgd lsdveeeeee
      841 emdvdeatga vkkhngvggs ppkskllfsn taaqklrgmd evynlfyvnn nwyifmrlhq
      901 ilclrllric sqaerqieee nrerewerev lgikrdksds paiqlrlkep mdvdvedyyp
      961 afldmvrsll dgnidssqye dslremftih ayiaftmdkl iqsivrqlqh ivsdeicvqv
     1021 tdlylaennn gatggqlntq nsrsllesty qrkaeqlmsd encfklmfiq sqgqvqltie
     1081 lldteeensd dpveaerwsd yverymnsdt tspelrehla qkpvflprnl rrirkcqrgr
     1141 eqqekegkeg nskktmenvd sldklecrfk lnsykmvyvi ksedymyrrt allrahqshe
     1201 rvskrlhqrf qawvdkwtke hvpremaaet skwlmgegle glvpctttcd tetlhfvsin
     1261 kyrvkygtvf kap
//
LOCUS       XP_047288312            1273 aa            linear   PRI 05-AUG-2025
DEFINITION  paired amphipathic helix protein Sin3a isoform X1 [Homo sapiens].
ACCESSION   XP_047288312
VERSION     XP_047288312.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432356.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1273
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1273
                     /product="paired amphipathic helix protein Sin3a isoform
                     X1"
                     /calculated_mol_wt=145045
     Region          5..1213
                     /region_name="Sin3"
                     /note="Histone deacetylase complex, regulatory component
                     SIN3 [Chromatin structure and dynamics]; COG5602"
                     /db_xref="CDD:227889"
     CDS             1..1273
                     /gene="SIN3A"
                     /gene_synonym="CHR15DELq24; DEL15Q24; WITKOS"
                     /coded_by="XM_047432356.1:80..3901"
                     /db_xref="GeneID:25942"
                     /db_xref="HGNC:HGNC:19353"
                     /db_xref="MIM:607776"
ORIGIN      
        1 mkrrlddqes pvyaaqqrri pgsteafphq hrvlapappv yeavsetmqs atgiqysvtp
       61 syqvsampqs sgshgpaiaa vhsshhhpta vqphggqvvq shahpappva pvqgqqqfqr
      121 lkvedalsyl dqvklqfgsq pqvyndfldi mkefksqsid tpgvisrvsq lfkghpdlim
      181 gfntflppgy kievqtndmv nvttpgqvhq ipthgiqpqp qpppqhpsqp saqsapapaq
      241 papqpppakv skpsqlqaht pasqqtpplp pyasprsppv qphtpvtisl gtapslqnnq
      301 pvefnhainy vnkiknrfqg qpdiykafle ilhtyqkeqr nakeaggnyt palteqevya
      361 qvarlfknqe dllsefgqfl pdanssvlls kttaekvdsv rndhggtvkk pqlnnkpqrp
      421 sqngcqirrh ptgttppvkk kpkllnlkds smadaskhgg gteslffdkv rkalrsaeay
      481 enflrclvif nqevisrael vqlvspflgk fpelfnwfkn flgykesvhl etypkerate
      541 giameidyas ckrlgssyra lpksyqqpkc tgrtplckev lndtwvsfps wsedstfvss
      601 kktqyeehiy rcederfeld vvletnlati rvleaiqkkl srlsaeeqak frldntlggt
      661 sevihrkalq riyadkaadi idglrknpsi avpivlkrlk mkeeewreaq rgfnkvwreq
      721 nekyylksld hqginfkqnd tkvlrsksll neiesiyder qeqateenag vpvgphlsla
      781 yedkqileda aaliihhvkr qtgiqkedky kikqimhhfi pdllfaqrgd lsdveeeeee
      841 emdvdeatga vkkhngvggs ppkskllfsn taaqklrgmd evynlfyvnn nwyifmrlhq
      901 ilclrllric sqaerqieee nrerewerev lgikrdksds paiqlrlkep mdvdvedyyp
      961 afldmvrsll dgnidssqye dslremftih ayiaftmdkl iqsivrqlqh ivsdeicvqv
     1021 tdlylaennn gatggqlntq nsrsllesty qrkaeqlmsd encfklmfiq sqgqvqltie
     1081 lldteeensd dpveaerwsd yverymnsdt tspelrehla qkpvflprnl rrirkcqrgr
     1141 eqqekegkeg nskktmenvd sldklecrfk lnsykmvyvi ksedymyrrt allrahqshe
     1201 rvskrlhqrf qawvdkwtke hvpremaaet skwlmgegle glvpctttcd tetlhfvsin
     1261 kyrvkygtvf kap
//
LOCUS       XP_047288314            1273 aa            linear   PRI 05-AUG-2025
DEFINITION  paired amphipathic helix protein Sin3a isoform X1 [Homo sapiens].
ACCESSION   XP_047288314
VERSION     XP_047288314.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432358.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1273
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1273
                     /product="paired amphipathic helix protein Sin3a isoform
                     X1"
                     /calculated_mol_wt=145045
     Region          5..1213
                     /region_name="Sin3"
                     /note="Histone deacetylase complex, regulatory component
                     SIN3 [Chromatin structure and dynamics]; COG5602"
                     /db_xref="CDD:227889"
     CDS             1..1273
                     /gene="SIN3A"
                     /gene_synonym="CHR15DELq24; DEL15Q24; WITKOS"
                     /coded_by="XM_047432358.1:152..3973"
                     /db_xref="GeneID:25942"
                     /db_xref="HGNC:HGNC:19353"
                     /db_xref="MIM:607776"
ORIGIN      
        1 mkrrlddqes pvyaaqqrri pgsteafphq hrvlapappv yeavsetmqs atgiqysvtp
       61 syqvsampqs sgshgpaiaa vhsshhhpta vqphggqvvq shahpappva pvqgqqqfqr
      121 lkvedalsyl dqvklqfgsq pqvyndfldi mkefksqsid tpgvisrvsq lfkghpdlim
      181 gfntflppgy kievqtndmv nvttpgqvhq ipthgiqpqp qpppqhpsqp saqsapapaq
      241 papqpppakv skpsqlqaht pasqqtpplp pyasprsppv qphtpvtisl gtapslqnnq
      301 pvefnhainy vnkiknrfqg qpdiykafle ilhtyqkeqr nakeaggnyt palteqevya
      361 qvarlfknqe dllsefgqfl pdanssvlls kttaekvdsv rndhggtvkk pqlnnkpqrp
      421 sqngcqirrh ptgttppvkk kpkllnlkds smadaskhgg gteslffdkv rkalrsaeay
      481 enflrclvif nqevisrael vqlvspflgk fpelfnwfkn flgykesvhl etypkerate
      541 giameidyas ckrlgssyra lpksyqqpkc tgrtplckev lndtwvsfps wsedstfvss
      601 kktqyeehiy rcederfeld vvletnlati rvleaiqkkl srlsaeeqak frldntlggt
      661 sevihrkalq riyadkaadi idglrknpsi avpivlkrlk mkeeewreaq rgfnkvwreq
      721 nekyylksld hqginfkqnd tkvlrsksll neiesiyder qeqateenag vpvgphlsla
      781 yedkqileda aaliihhvkr qtgiqkedky kikqimhhfi pdllfaqrgd lsdveeeeee
      841 emdvdeatga vkkhngvggs ppkskllfsn taaqklrgmd evynlfyvnn nwyifmrlhq
      901 ilclrllric sqaerqieee nrerewerev lgikrdksds paiqlrlkep mdvdvedyyp
      961 afldmvrsll dgnidssqye dslremftih ayiaftmdkl iqsivrqlqh ivsdeicvqv
     1021 tdlylaennn gatggqlntq nsrsllesty qrkaeqlmsd encfklmfiq sqgqvqltie
     1081 lldteeensd dpveaerwsd yverymnsdt tspelrehla qkpvflprnl rrirkcqrgr
     1141 eqqekegkeg nskktmenvd sldklecrfk lnsykmvyvi ksedymyrrt allrahqshe
     1201 rvskrlhqrf qawvdkwtke hvpremaaet skwlmgegle glvpctttcd tetlhfvsin
     1261 kyrvkygtvf kap
//
LOCUS       XP_047288315            1273 aa            linear   PRI 05-AUG-2025
DEFINITION  paired amphipathic helix protein Sin3a isoform X1 [Homo sapiens].
ACCESSION   XP_047288315
VERSION     XP_047288315.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432359.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1273
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1273
                     /product="paired amphipathic helix protein Sin3a isoform
                     X1"
                     /calculated_mol_wt=145045
     Region          5..1213
                     /region_name="Sin3"
                     /note="Histone deacetylase complex, regulatory component
                     SIN3 [Chromatin structure and dynamics]; COG5602"
                     /db_xref="CDD:227889"
     CDS             1..1273
                     /gene="SIN3A"
                     /gene_synonym="CHR15DELq24; DEL15Q24; WITKOS"
                     /coded_by="XM_047432359.1:247..4068"
                     /db_xref="GeneID:25942"
                     /db_xref="HGNC:HGNC:19353"
                     /db_xref="MIM:607776"
ORIGIN      
        1 mkrrlddqes pvyaaqqrri pgsteafphq hrvlapappv yeavsetmqs atgiqysvtp
       61 syqvsampqs sgshgpaiaa vhsshhhpta vqphggqvvq shahpappva pvqgqqqfqr
      121 lkvedalsyl dqvklqfgsq pqvyndfldi mkefksqsid tpgvisrvsq lfkghpdlim
      181 gfntflppgy kievqtndmv nvttpgqvhq ipthgiqpqp qpppqhpsqp saqsapapaq
      241 papqpppakv skpsqlqaht pasqqtpplp pyasprsppv qphtpvtisl gtapslqnnq
      301 pvefnhainy vnkiknrfqg qpdiykafle ilhtyqkeqr nakeaggnyt palteqevya
      361 qvarlfknqe dllsefgqfl pdanssvlls kttaekvdsv rndhggtvkk pqlnnkpqrp
      421 sqngcqirrh ptgttppvkk kpkllnlkds smadaskhgg gteslffdkv rkalrsaeay
      481 enflrclvif nqevisrael vqlvspflgk fpelfnwfkn flgykesvhl etypkerate
      541 giameidyas ckrlgssyra lpksyqqpkc tgrtplckev lndtwvsfps wsedstfvss
      601 kktqyeehiy rcederfeld vvletnlati rvleaiqkkl srlsaeeqak frldntlggt
      661 sevihrkalq riyadkaadi idglrknpsi avpivlkrlk mkeeewreaq rgfnkvwreq
      721 nekyylksld hqginfkqnd tkvlrsksll neiesiyder qeqateenag vpvgphlsla
      781 yedkqileda aaliihhvkr qtgiqkedky kikqimhhfi pdllfaqrgd lsdveeeeee
      841 emdvdeatga vkkhngvggs ppkskllfsn taaqklrgmd evynlfyvnn nwyifmrlhq
      901 ilclrllric sqaerqieee nrerewerev lgikrdksds paiqlrlkep mdvdvedyyp
      961 afldmvrsll dgnidssqye dslremftih ayiaftmdkl iqsivrqlqh ivsdeicvqv
     1021 tdlylaennn gatggqlntq nsrsllesty qrkaeqlmsd encfklmfiq sqgqvqltie
     1081 lldteeensd dpveaerwsd yverymnsdt tspelrehla qkpvflprnl rrirkcqrgr
     1141 eqqekegkeg nskktmenvd sldklecrfk lnsykmvyvi ksedymyrrt allrahqshe
     1201 rvskrlhqrf qawvdkwtke hvpremaaet skwlmgegle glvpctttcd tetlhfvsin
     1261 kyrvkygtvf kap
//
LOCUS       XP_047288316            1273 aa            linear   PRI 05-AUG-2025
DEFINITION  paired amphipathic helix protein Sin3a isoform X1 [Homo sapiens].
ACCESSION   XP_047288316
VERSION     XP_047288316.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432360.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1273
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1273
                     /product="paired amphipathic helix protein Sin3a isoform
                     X1"
                     /calculated_mol_wt=145045
     Region          5..1213
                     /region_name="Sin3"
                     /note="Histone deacetylase complex, regulatory component
                     SIN3 [Chromatin structure and dynamics]; COG5602"
                     /db_xref="CDD:227889"
     CDS             1..1273
                     /gene="SIN3A"
                     /gene_synonym="CHR15DELq24; DEL15Q24; WITKOS"
                     /coded_by="XM_047432360.1:2106..5927"
                     /db_xref="GeneID:25942"
                     /db_xref="HGNC:HGNC:19353"
                     /db_xref="MIM:607776"
ORIGIN      
        1 mkrrlddqes pvyaaqqrri pgsteafphq hrvlapappv yeavsetmqs atgiqysvtp
       61 syqvsampqs sgshgpaiaa vhsshhhpta vqphggqvvq shahpappva pvqgqqqfqr
      121 lkvedalsyl dqvklqfgsq pqvyndfldi mkefksqsid tpgvisrvsq lfkghpdlim
      181 gfntflppgy kievqtndmv nvttpgqvhq ipthgiqpqp qpppqhpsqp saqsapapaq
      241 papqpppakv skpsqlqaht pasqqtpplp pyasprsppv qphtpvtisl gtapslqnnq
      301 pvefnhainy vnkiknrfqg qpdiykafle ilhtyqkeqr nakeaggnyt palteqevya
      361 qvarlfknqe dllsefgqfl pdanssvlls kttaekvdsv rndhggtvkk pqlnnkpqrp
      421 sqngcqirrh ptgttppvkk kpkllnlkds smadaskhgg gteslffdkv rkalrsaeay
      481 enflrclvif nqevisrael vqlvspflgk fpelfnwfkn flgykesvhl etypkerate
      541 giameidyas ckrlgssyra lpksyqqpkc tgrtplckev lndtwvsfps wsedstfvss
      601 kktqyeehiy rcederfeld vvletnlati rvleaiqkkl srlsaeeqak frldntlggt
      661 sevihrkalq riyadkaadi idglrknpsi avpivlkrlk mkeeewreaq rgfnkvwreq
      721 nekyylksld hqginfkqnd tkvlrsksll neiesiyder qeqateenag vpvgphlsla
      781 yedkqileda aaliihhvkr qtgiqkedky kikqimhhfi pdllfaqrgd lsdveeeeee
      841 emdvdeatga vkkhngvggs ppkskllfsn taaqklrgmd evynlfyvnn nwyifmrlhq
      901 ilclrllric sqaerqieee nrerewerev lgikrdksds paiqlrlkep mdvdvedyyp
      961 afldmvrsll dgnidssqye dslremftih ayiaftmdkl iqsivrqlqh ivsdeicvqv
     1021 tdlylaennn gatggqlntq nsrsllesty qrkaeqlmsd encfklmfiq sqgqvqltie
     1081 lldteeensd dpveaerwsd yverymnsdt tspelrehla qkpvflprnl rrirkcqrgr
     1141 eqqekegkeg nskktmenvd sldklecrfk lnsykmvyvi ksedymyrrt allrahqshe
     1201 rvskrlhqrf qawvdkwtke hvpremaaet skwlmgegle glvpctttcd tetlhfvsin
     1261 kyrvkygtvf kap
//
LOCUS       XP_047288317            1273 aa            linear   PRI 05-AUG-2025
DEFINITION  paired amphipathic helix protein Sin3a isoform X1 [Homo sapiens].
ACCESSION   XP_047288317
VERSION     XP_047288317.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432361.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1273
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1273
                     /product="paired amphipathic helix protein Sin3a isoform
                     X1"
                     /calculated_mol_wt=145045
     Region          5..1213
                     /region_name="Sin3"
                     /note="Histone deacetylase complex, regulatory component
                     SIN3 [Chromatin structure and dynamics]; COG5602"
                     /db_xref="CDD:227889"
     CDS             1..1273
                     /gene="SIN3A"
                     /gene_synonym="CHR15DELq24; DEL15Q24; WITKOS"
                     /coded_by="XM_047432361.1:563..4384"
                     /db_xref="GeneID:25942"
                     /db_xref="HGNC:HGNC:19353"
                     /db_xref="MIM:607776"
ORIGIN      
        1 mkrrlddqes pvyaaqqrri pgsteafphq hrvlapappv yeavsetmqs atgiqysvtp
       61 syqvsampqs sgshgpaiaa vhsshhhpta vqphggqvvq shahpappva pvqgqqqfqr
      121 lkvedalsyl dqvklqfgsq pqvyndfldi mkefksqsid tpgvisrvsq lfkghpdlim
      181 gfntflppgy kievqtndmv nvttpgqvhq ipthgiqpqp qpppqhpsqp saqsapapaq
      241 papqpppakv skpsqlqaht pasqqtpplp pyasprsppv qphtpvtisl gtapslqnnq
      301 pvefnhainy vnkiknrfqg qpdiykafle ilhtyqkeqr nakeaggnyt palteqevya
      361 qvarlfknqe dllsefgqfl pdanssvlls kttaekvdsv rndhggtvkk pqlnnkpqrp
      421 sqngcqirrh ptgttppvkk kpkllnlkds smadaskhgg gteslffdkv rkalrsaeay
      481 enflrclvif nqevisrael vqlvspflgk fpelfnwfkn flgykesvhl etypkerate
      541 giameidyas ckrlgssyra lpksyqqpkc tgrtplckev lndtwvsfps wsedstfvss
      601 kktqyeehiy rcederfeld vvletnlati rvleaiqkkl srlsaeeqak frldntlggt
      661 sevihrkalq riyadkaadi idglrknpsi avpivlkrlk mkeeewreaq rgfnkvwreq
      721 nekyylksld hqginfkqnd tkvlrsksll neiesiyder qeqateenag vpvgphlsla
      781 yedkqileda aaliihhvkr qtgiqkedky kikqimhhfi pdllfaqrgd lsdveeeeee
      841 emdvdeatga vkkhngvggs ppkskllfsn taaqklrgmd evynlfyvnn nwyifmrlhq
      901 ilclrllric sqaerqieee nrerewerev lgikrdksds paiqlrlkep mdvdvedyyp
      961 afldmvrsll dgnidssqye dslremftih ayiaftmdkl iqsivrqlqh ivsdeicvqv
     1021 tdlylaennn gatggqlntq nsrsllesty qrkaeqlmsd encfklmfiq sqgqvqltie
     1081 lldteeensd dpveaerwsd yverymnsdt tspelrehla qkpvflprnl rrirkcqrgr
     1141 eqqekegkeg nskktmenvd sldklecrfk lnsykmvyvi ksedymyrrt allrahqshe
     1201 rvskrlhqrf qawvdkwtke hvpremaaet skwlmgegle glvpctttcd tetlhfvsin
     1261 kyrvkygtvf kap
//
LOCUS       XP_047288318            1273 aa            linear   PRI 05-AUG-2025
DEFINITION  paired amphipathic helix protein Sin3a isoform X1 [Homo sapiens].
ACCESSION   XP_047288318
VERSION     XP_047288318.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432362.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1273
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1273
                     /product="paired amphipathic helix protein Sin3a isoform
                     X1"
                     /calculated_mol_wt=145045
     Region          5..1213
                     /region_name="Sin3"
                     /note="Histone deacetylase complex, regulatory component
                     SIN3 [Chromatin structure and dynamics]; COG5602"
                     /db_xref="CDD:227889"
     CDS             1..1273
                     /gene="SIN3A"
                     /gene_synonym="CHR15DELq24; DEL15Q24; WITKOS"
                     /coded_by="XM_047432362.1:443..4264"
                     /db_xref="GeneID:25942"
                     /db_xref="HGNC:HGNC:19353"
                     /db_xref="MIM:607776"
ORIGIN      
        1 mkrrlddqes pvyaaqqrri pgsteafphq hrvlapappv yeavsetmqs atgiqysvtp
       61 syqvsampqs sgshgpaiaa vhsshhhpta vqphggqvvq shahpappva pvqgqqqfqr
      121 lkvedalsyl dqvklqfgsq pqvyndfldi mkefksqsid tpgvisrvsq lfkghpdlim
      181 gfntflppgy kievqtndmv nvttpgqvhq ipthgiqpqp qpppqhpsqp saqsapapaq
      241 papqpppakv skpsqlqaht pasqqtpplp pyasprsppv qphtpvtisl gtapslqnnq
      301 pvefnhainy vnkiknrfqg qpdiykafle ilhtyqkeqr nakeaggnyt palteqevya
      361 qvarlfknqe dllsefgqfl pdanssvlls kttaekvdsv rndhggtvkk pqlnnkpqrp
      421 sqngcqirrh ptgttppvkk kpkllnlkds smadaskhgg gteslffdkv rkalrsaeay
      481 enflrclvif nqevisrael vqlvspflgk fpelfnwfkn flgykesvhl etypkerate
      541 giameidyas ckrlgssyra lpksyqqpkc tgrtplckev lndtwvsfps wsedstfvss
      601 kktqyeehiy rcederfeld vvletnlati rvleaiqkkl srlsaeeqak frldntlggt
      661 sevihrkalq riyadkaadi idglrknpsi avpivlkrlk mkeeewreaq rgfnkvwreq
      721 nekyylksld hqginfkqnd tkvlrsksll neiesiyder qeqateenag vpvgphlsla
      781 yedkqileda aaliihhvkr qtgiqkedky kikqimhhfi pdllfaqrgd lsdveeeeee
      841 emdvdeatga vkkhngvggs ppkskllfsn taaqklrgmd evynlfyvnn nwyifmrlhq
      901 ilclrllric sqaerqieee nrerewerev lgikrdksds paiqlrlkep mdvdvedyyp
      961 afldmvrsll dgnidssqye dslremftih ayiaftmdkl iqsivrqlqh ivsdeicvqv
     1021 tdlylaennn gatggqlntq nsrsllesty qrkaeqlmsd encfklmfiq sqgqvqltie
     1081 lldteeensd dpveaerwsd yverymnsdt tspelrehla qkpvflprnl rrirkcqrgr
     1141 eqqekegkeg nskktmenvd sldklecrfk lnsykmvyvi ksedymyrrt allrahqshe
     1201 rvskrlhqrf qawvdkwtke hvpremaaet skwlmgegle glvpctttcd tetlhfvsin
     1261 kyrvkygtvf kap
//
LOCUS       XP_047288319             656 aa            linear   PRI 05-AUG-2025
DEFINITION  paired amphipathic helix protein Sin3a isoform X2 [Homo sapiens].
ACCESSION   XP_047288319
VERSION     XP_047288319.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432363.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..656
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..656
                     /product="paired amphipathic helix protein Sin3a isoform
                     X2"
                     /calculated_mol_wt=76409
     Region          269..569
                     /region_name="Sin3a_C"
                     /note="C-terminal domain of Sin3a protein; pfam16879"
                     /db_xref="CDD:465294"
     CDS             1..656
                     /gene="SIN3A"
                     /gene_synonym="CHR15DELq24; DEL15Q24; WITKOS"
                     /coded_by="XM_047432363.1:21..1991"
                     /db_xref="GeneID:25942"
                     /db_xref="HGNC:HGNC:19353"
                     /db_xref="MIM:607776"
ORIGIN      
        1 mldvvletnl atirvleaiq kklsrlsaee qakfrldntl ggtsevihrk alqriyadka
       61 adiidglrkn psiavpivlk rlkmkeeewr eaqrgfnkvw reqnekyylk sldhqginfk
      121 qndtkvlrsk sllneiesiy derqeqatee nagvpvgphl slayedkqil edaaaliihh
      181 vkrqtgiqke dkykikqimh hfipdllfaq rgdlsdveee eeeemdvdea tgavkkhngv
      241 ggsppkskll fsntaaqklr gmdevynlfy vnnnwyifmr lhqilclrll ricsqaerqi
      301 eeenrerewe revlgikrdk sdspaiqlrl kepmdvdved yypafldmvr slldgnidss
      361 qyedslremf tihayiaftm dkliqsivrq lqhivsdeic vqvtdlylae nnngatggql
      421 ntqnsrslle styqrkaeql msdencfklm fiqsqgqvql tielldteee nsddpveaer
      481 wsdyverymn sdttspelre hlaqkpvflp rnlrrirkcq rgreqqekeg kegnskktme
      541 nvdsldklec rfklnsykmv yviksedymy rrtallrahq shervskrlh qrfqawvdkw
      601 tkehvprema aetskwlmge gleglvpctt tcdtetlhfv sinkyrvkyg tvfkap
//
LOCUS       XP_011519746             354 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 87A isoform X4 [Homo sapiens].
ACCESSION   XP_011519746
VERSION     XP_011519746.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521444.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..354
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..354
                     /product="transmembrane protein 87A isoform X4"
                     /calculated_mol_wt=39791
     Region          206..>354
                     /region_name="Lung_7-TM_R"
                     /note="Lung seven transmembrane receptor; cl21735"
                     /db_xref="CDD:473945"
     CDS             1..354
                     /gene="TMEM87A"
                     /gene_synonym="ELKIN1"
                     /coded_by="XM_011521444.4:187..1251"
                     /db_xref="GeneID:25963"
                     /db_xref="HGNC:HGNC:24522"
ORIGIN      
        1 maaaawlqvl pvillllgah psplsffsag patvaaadrs kwhipipsgk nyfsfgkilf
       61 rnttiflkfd gepcdlslni twylksadcy neiynfkaee velyleklke krglsgkyqt
      121 ssklfqncse lfktqtfsgd fmhrlpllge kqeakengtn ltfigdktam heplqtwqda
      181 pyifivhigi ssskessken slsnlftmtv evkgpyeylt ledyplmiff mvmcivyvlf
      241 gvlwlawsac ywrdllriqf wigaviflgm lekavfyaef qnirykgesv qgalilaell
      301 savkrslart lviivslgyg ivkprlgvtl hkvvvagaly llfsgmegvl rvtg
//
LOCUS       XP_005254346             483 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase ULK3 isoform X1 [Homo sapiens].
ACCESSION   XP_005254346
VERSION     XP_005254346.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254289.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..483
                     /product="serine/threonine-protein kinase ULK3 isoform X1"
                     /calculated_mol_wt=54866
     Region          46..280
                     /region_name="STKc_ULK3"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Unc-51-like kinase 3; cd14121"
                     /db_xref="CDD:271023"
     Site            order(109,111,148,150,152,171,186..189)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:271023"
     Site            order(167..177,179..189)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:271023"
     Region          290..364
                     /region_name="MIT_2"
                     /note="MIT: domain contained within Microtubule
                     Interacting and Trafficking molecules. This sub-family of
                     MIT domains is found in proteins with an n-terminal
                     serine/threonine kinase domain. The molecular function of
                     the MIT domain is unclear; cd02684"
                     /db_xref="CDD:239147"
     Region          385..460
                     /region_name="MIT"
                     /note="domain contained within Microtubule Interacting and
                     Trafficking molecules. The MIT domain is found in sorting
                     nexins, the nuclear thiol protease PalBH, the AAA protein
                     spastin and archaebacterial proteins with similar domain
                     architecture, vacuolar...; cl00299"
                     /db_xref="CDD:469712"
     CDS             1..483
                     /gene="ULK3"
                     /coded_by="XM_005254289.3:155..1606"
                     /db_xref="GeneID:25989"
                     /db_xref="HGNC:HGNC:19703"
                     /db_xref="MIM:613472"
ORIGIN      
        1 mqrngsasrg lektrlrlcr earipesafl tgltreswea rcwcakdtre vvaikcvakk
       61 slnkasvenl lteieilkgi rhphivqlkd fqwdsdniyl imefcaggdl srfihtrril
      121 pekvarvfmq qlasalqflh ernishldlk pqnillssle kphlkladfg faqhmspwde
      181 khvlrgsply mapemvcqrq ydarvdlwsm gvilyealfg qppfasrsfs eleekirsnr
      241 vielplrpll srdcrdllqr llerdpsrri sfqdffahpw vdlehmpsge slgratalvv
      301 qavkkdqegd saaalslyck aldffvpalh yevdaqrkea ikakvgqyvs raeelkaivs
      361 ssnqallrqg tsardllrem ardkprllaa levasaamak eeaaggeqda ldlyqhslge
      421 lllllaaepp grrrellhte vqnlmaraey lkeqvkmres rweadtldke glsesvrssc
      481 tlq
//
LOCUS       XP_047288324             481 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase ULK3 isoform X2 [Homo sapiens].
ACCESSION   XP_047288324
VERSION     XP_047288324.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432368.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..481
                     /product="serine/threonine-protein kinase ULK3 isoform X2"
                     /calculated_mol_wt=54639
     Region          46..280
                     /region_name="STKc_ULK3"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Unc-51-like kinase 3; cd14121"
                     /db_xref="CDD:271023"
     Site            order(109,111,148,150,152,171,186..189)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:271023"
     Site            order(167..177,179..189)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:271023"
     Region          290..364
                     /region_name="MIT_2"
                     /note="MIT: domain contained within Microtubule
                     Interacting and Trafficking molecules. This sub-family of
                     MIT domains is found in proteins with an n-terminal
                     serine/threonine kinase domain. The molecular function of
                     the MIT domain is unclear; cd02684"
                     /db_xref="CDD:239147"
     Region          385..453
                     /region_name="MIT"
                     /note="domain contained within Microtubule Interacting and
                     Trafficking molecules. The MIT domain is found in sorting
                     nexins, the nuclear thiol protease PalBH, the AAA protein
                     spastin and archaebacterial proteins with similar domain
                     architecture, vacuolar...; cl00299"
                     /db_xref="CDD:469712"
     CDS             1..481
                     /gene="ULK3"
                     /coded_by="XM_047432368.1:4..1449"
                     /db_xref="GeneID:25989"
                     /db_xref="HGNC:HGNC:19703"
                     /db_xref="MIM:613472"
ORIGIN      
        1 mqrngsasrg lektrlrlcr earipesafl tgltreswea rcwcakdtre vvaikcvakk
       61 slnkasvenl lteieilkgi rhphivqlkd fqwdsdniyl imefcaggdl srfihtrril
      121 pekvarvfmq qlasalqflh ernishldlk pqnillssle kphlkladfg faqhmspwde
      181 khvlrgsply mapemvcqrq ydarvdlwsm gvilyealfg qppfasrsfs eleekirsnr
      241 vielplrpll srdcrdllqr llerdpsrri sfqdffahpw vdlehmpsge slgratalvv
      301 qavkkdqegd saaalslyck aldffvpalh yevdaqrkea ikakvgqyvs raeelkaivs
      361 ssnqallrqg tsardllrem ardkprllaa levasaamak eeaaggeqda ldlyqhslge
      421 lllllaaepp grrrellhte vqnlmaraey lkeqmresrw eadtldkegl sesvrssctl
      481 q
//
LOCUS       XP_016877557             481 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase ULK3 isoform X2 [Homo sapiens].
ACCESSION   XP_016877557
VERSION     XP_016877557.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022068.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..481
                     /product="serine/threonine-protein kinase ULK3 isoform X2"
                     /calculated_mol_wt=54639
     Region          46..280
                     /region_name="STKc_ULK3"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Unc-51-like kinase 3; cd14121"
                     /db_xref="CDD:271023"
     Site            order(109,111,148,150,152,171,186..189)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:271023"
     Site            order(167..177,179..189)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:271023"
     Region          290..364
                     /region_name="MIT_2"
                     /note="MIT: domain contained within Microtubule
                     Interacting and Trafficking molecules. This sub-family of
                     MIT domains is found in proteins with an n-terminal
                     serine/threonine kinase domain. The molecular function of
                     the MIT domain is unclear; cd02684"
                     /db_xref="CDD:239147"
     Region          385..453
                     /region_name="MIT"
                     /note="domain contained within Microtubule Interacting and
                     Trafficking molecules. The MIT domain is found in sorting
                     nexins, the nuclear thiol protease PalBH, the AAA protein
                     spastin and archaebacterial proteins with similar domain
                     architecture, vacuolar...; cl00299"
                     /db_xref="CDD:469712"
     CDS             1..481
                     /gene="ULK3"
                     /coded_by="XM_017022068.2:155..1600"
                     /db_xref="GeneID:25989"
                     /db_xref="HGNC:HGNC:19703"
                     /db_xref="MIM:613472"
ORIGIN      
        1 mqrngsasrg lektrlrlcr earipesafl tgltreswea rcwcakdtre vvaikcvakk
       61 slnkasvenl lteieilkgi rhphivqlkd fqwdsdniyl imefcaggdl srfihtrril
      121 pekvarvfmq qlasalqflh ernishldlk pqnillssle kphlkladfg faqhmspwde
      181 khvlrgsply mapemvcqrq ydarvdlwsm gvilyealfg qppfasrsfs eleekirsnr
      241 vielplrpll srdcrdllqr llerdpsrri sfqdffahpw vdlehmpsge slgratalvv
      301 qavkkdqegd saaalslyck aldffvpalh yevdaqrkea ikakvgqyvs raeelkaivs
      361 ssnqallrqg tsardllrem ardkprllaa levasaamak eeaaggeqda ldlyqhslge
      421 lllllaaepp grrrellhte vqnlmaraey lkeqmresrw eadtldkegl sesvrssctl
      481 q
//
LOCUS       XP_047288325             438 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase ULK3 isoform X3 [Homo sapiens].
ACCESSION   XP_047288325
VERSION     XP_047288325.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432369.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..438
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..438
                     /product="serine/threonine-protein kinase ULK3 isoform X3"
                     /calculated_mol_wt=49280
     Region          18..269
                     /region_name="STKc_ULK3"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Unc-51-like kinase 3; cd14121"
                     /db_xref="CDD:271023"
     Site            order(20..24,28,42,44,75,91..94,98,100,137,139,141..142,
                     144,157,160,175..178)
                     /site_type="active"
                     /db_xref="CDD:271023"
     Site            order(20..24,28,42,44,75,91..94,98,137,139,141..142,144,
                     157)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271023"
     Site            order(24,98,100,137,139,141,160,175..178)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:271023"
     Site            order(156..166,168..178)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:271023"
     Region          279..353
                     /region_name="MIT_2"
                     /note="MIT: domain contained within Microtubule
                     Interacting and Trafficking molecules. This sub-family of
                     MIT domains is found in proteins with an n-terminal
                     serine/threonine kinase domain. The molecular function of
                     the MIT domain is unclear; cd02684"
                     /db_xref="CDD:239147"
     CDS             1..438
                     /gene="ULK3"
                     /coded_by="XM_047432369.1:52..1368"
                     /db_xref="GeneID:25989"
                     /db_xref="HGNC:HGNC:19703"
                     /db_xref="MIM:613472"
ORIGIN      
        1 magpgwgppr ldgfilterl gsgtyatvyk ayakkdtrev vaikcvakks lnkasvenll
       61 teieilkgir hphivqlkdf qwdsdniyli mefcaggdls rfihtrrilp ekvarvfmqq
      121 lasalqflhe rnishldlkp qnillsslek phlkladfgf aqhmspwdek hvlrgsplym
      181 apemvcqrqy darvdlwsmg vilyealfgq ppfasrsfse leekirsnrv ielplrplls
      241 rdcrdllqrl lerdpsrris fqdffahpwv dlehmpsges lgratalvvq avkkdqegds
      301 aaalslycka ldffvpalhy evdaqrkeai kakvgqyvsr aeelkaivss snqallrqgt
      361 sardllrema rdkprllaal evasaamake eaaggeqdal dlyqhslgel llllrsprag
      421 ggscftlrfr tswpelnt
//
LOCUS       XP_047288326             438 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase ULK3 isoform X3 [Homo sapiens].
ACCESSION   XP_047288326
VERSION     XP_047288326.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432370.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..438
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..438
                     /product="serine/threonine-protein kinase ULK3 isoform X3"
                     /calculated_mol_wt=49280
     Region          18..269
                     /region_name="STKc_ULK3"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Unc-51-like kinase 3; cd14121"
                     /db_xref="CDD:271023"
     Site            order(20..24,28,42,44,75,91..94,98,100,137,139,141..142,
                     144,157,160,175..178)
                     /site_type="active"
                     /db_xref="CDD:271023"
     Site            order(20..24,28,42,44,75,91..94,98,137,139,141..142,144,
                     157)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271023"
     Site            order(24,98,100,137,139,141,160,175..178)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:271023"
     Site            order(156..166,168..178)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:271023"
     Region          279..353
                     /region_name="MIT_2"
                     /note="MIT: domain contained within Microtubule
                     Interacting and Trafficking molecules. This sub-family of
                     MIT domains is found in proteins with an n-terminal
                     serine/threonine kinase domain. The molecular function of
                     the MIT domain is unclear; cd02684"
                     /db_xref="CDD:239147"
     CDS             1..438
                     /gene="ULK3"
                     /coded_by="XM_047432370.1:52..1368"
                     /db_xref="GeneID:25989"
                     /db_xref="HGNC:HGNC:19703"
                     /db_xref="MIM:613472"
ORIGIN      
        1 magpgwgppr ldgfilterl gsgtyatvyk ayakkdtrev vaikcvakks lnkasvenll
       61 teieilkgir hphivqlkdf qwdsdniyli mefcaggdls rfihtrrilp ekvarvfmqq
      121 lasalqflhe rnishldlkp qnillsslek phlkladfgf aqhmspwdek hvlrgsplym
      181 apemvcqrqy darvdlwsmg vilyealfgq ppfasrsfse leekirsnrv ielplrplls
      241 rdcrdllqrl lerdpsrris fqdffahpwv dlehmpsges lgratalvvq avkkdqegds
      301 aaalslycka ldffvpalhy evdaqrkeai kakvgqyvsr aeelkaivss snqallrqgt
      361 sardllrema rdkprllaal evasaamake eaaggeqdal dlyqhslgel llllrsprag
      421 ggscftlrfr tswpelnt
//
LOCUS       XP_047288327             413 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase ULK3 isoform X4 [Homo sapiens].
ACCESSION   XP_047288327
VERSION     XP_047288327.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432371.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..413
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..413
                     /product="serine/threonine-protein kinase ULK3 isoform X4"
                     /calculated_mol_wt=46600
     Region          18..269
                     /region_name="STKc_ULK3"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Unc-51-like kinase 3; cd14121"
                     /db_xref="CDD:271023"
     Site            order(20..24,28,42,44,75,91..94,98,100,137,139,141..142,
                     144,157,160,175..178)
                     /site_type="active"
                     /db_xref="CDD:271023"
     Site            order(20..24,28,42,44,75,91..94,98,137,139,141..142,144,
                     157)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271023"
     Site            order(24,98,100,137,139,141,160,175..178)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:271023"
     Site            order(156..166,168..178)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:271023"
     Region          279..353
                     /region_name="MIT_2"
                     /note="MIT: domain contained within Microtubule
                     Interacting and Trafficking molecules. This sub-family of
                     MIT domains is found in proteins with an n-terminal
                     serine/threonine kinase domain. The molecular function of
                     the MIT domain is unclear; cd02684"
                     /db_xref="CDD:239147"
     CDS             1..413
                     /gene="ULK3"
                     /coded_by="XM_047432371.1:52..1293"
                     /db_xref="GeneID:25989"
                     /db_xref="HGNC:HGNC:19703"
                     /db_xref="MIM:613472"
ORIGIN      
        1 magpgwgppr ldgfilterl gsgtyatvyk ayakkdtrev vaikcvakks lnkasvenll
       61 teieilkgir hphivqlkdf qwdsdniyli mefcaggdls rfihtrrilp ekvarvfmqq
      121 lasalqflhe rnishldlkp qnillsslek phlkladfgf aqhmspwdek hvlrgsplym
      181 apemvcqrqy darvdlwsmg vilyealfgq ppfasrsfse leekirsnrv ielplrplls
      241 rdcrdllqrl lerdpsrris fqdffahpwv dlehmpsges lgratalvvq avkkdqegds
      301 aaalslycka ldffvpalhy evdaqrkeai kakvgqyvsr aeelkaivss snqallrqgt
      361 sardllrema rdkprllaal evasaamakr spragggscf tlrfrtswpe lnt
//
LOCUS       XP_047288328             342 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase ULK3 isoform X5 [Homo sapiens].
ACCESSION   XP_047288328
VERSION     XP_047288328.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432372.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..342
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..342
                     /product="serine/threonine-protein kinase ULK3 isoform X5"
                     /calculated_mol_wt=38877
     Region          18..269
                     /region_name="STKc_ULK3"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Unc-51-like kinase 3; cd14121"
                     /db_xref="CDD:271023"
     Site            order(20..24,28,42,44,75,91..94,98,100,137,139,141..142,
                     144,157,160,175..178)
                     /site_type="active"
                     /db_xref="CDD:271023"
     Site            order(20..24,28,42,44,75,91..94,98,137,139,141..142,144,
                     157)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271023"
     Site            order(24,98,100,137,139,141,160,175..178)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:271023"
     Site            order(156..166,168..178)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:271023"
     Region          279..>333
                     /region_name="MIT"
                     /note="domain contained within Microtubule Interacting and
                     Trafficking molecules. The MIT domain is found in sorting
                     nexins, the nuclear thiol protease PalBH, the AAA protein
                     spastin and archaebacterial proteins with similar domain
                     architecture, vacuolar...; cl00299"
                     /db_xref="CDD:469712"
     CDS             1..342
                     /gene="ULK3"
                     /coded_by="XM_047432372.1:52..1080"
                     /db_xref="GeneID:25989"
                     /db_xref="HGNC:HGNC:19703"
                     /db_xref="MIM:613472"
ORIGIN      
        1 magpgwgppr ldgfilterl gsgtyatvyk ayakkdtrev vaikcvakks lnkasvenll
       61 teieilkgir hphivqlkdf qwdsdniyli mefcaggdls rfihtrrilp ekvarvfmqq
      121 lasalqflhe rnishldlkp qnillsslek phlkladfgf aqhmspwdek hvlrgsplym
      181 apemvcqrqy darvdlwsmg vilyealfgq ppfasrsfse leekirsnrv ielplrplls
      241 rdcrdllqrl lerdpsrris fqdffahpwv dlehmpsges lgratalvvq avkkdqegds
      301 aaalslycka ldffvpalhy evdaqrkeai kakrwpgtsh as
//
LOCUS       XP_047288329             382 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase ULK3 isoform X6 [Homo sapiens].
ACCESSION   XP_047288329
VERSION     XP_047288329.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432373.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..382
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..382
                     /product="serine/threonine-protein kinase ULK3 isoform X6"
                     /calculated_mol_wt=43230
     Region          <1..179
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Region          189..263
                     /region_name="MIT_2"
                     /note="MIT: domain contained within Microtubule
                     Interacting and Trafficking molecules. This sub-family of
                     MIT domains is found in proteins with an n-terminal
                     serine/threonine kinase domain. The molecular function of
                     the MIT domain is unclear; cd02684"
                     /db_xref="CDD:239147"
     Region          284..359
                     /region_name="MIT"
                     /note="domain contained within Microtubule Interacting and
                     Trafficking molecules. The MIT domain is found in sorting
                     nexins, the nuclear thiol protease PalBH, the AAA protein
                     spastin and archaebacterial proteins with similar domain
                     architecture, vacuolar...; cl00299"
                     /db_xref="CDD:469712"
     CDS             1..382
                     /gene="ULK3"
                     /coded_by="XM_047432373.1:300..1448"
                     /db_xref="GeneID:25989"
                     /db_xref="HGNC:HGNC:19703"
                     /db_xref="MIM:613472"
ORIGIN      
        1 mefcaggdls rfihtrrilp ekvarvfmqq lasalqflhe rnishldlkp qnillsslek
       61 phlkladfgf aqhmspwdek hvlrgsplym apemvcqrqy darvdlwsmg vilyealfgq
      121 ppfasrsfse leekirsnrv ielplrplls rdcrdllqrl lerdpsrris fqdffahpwv
      181 dlehmpsges lgratalvvq avkkdqegds aaalslycka ldffvpalhy evdaqrkeai
      241 kakvgqyvsr aeelkaivss snqallrqgt sardllrema rdkprllaal evasaamake
      301 eaaggeqdal dlyqhslgel llllaaeppg rrrellhtev qnlmaraeyl keqvkmresr
      361 weadtldkeg lsesvrssct lq
//
LOCUS       XP_005254354            1393 aa            linear   PRI 05-AUG-2025
DEFINITION  RNA polymerase II-associated protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_005254354
VERSION     XP_005254354.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254297.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1393
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1393
                     /product="RNA polymerase II-associated protein 1 isoform
                     X1"
                     /calculated_mol_wt=152624
     Region          225..270
                     /region_name="RPAP1_N"
                     /note="RPAP1-like, N-terminal; pfam08621"
                     /db_xref="CDD:462539"
     Region          356..421
                     /region_name="RPAP1_C"
                     /note="RPAP1-like, C-terminal; pfam08620"
                     /db_xref="CDD:462538"
     CDS             1..1393
                     /gene="RPAP1"
                     /coded_by="XM_005254297.2:422..4603"
                     /db_xref="GeneID:26015"
                     /db_xref="HGNC:HGNC:24567"
                     /db_xref="MIM:611475"
ORIGIN      
        1 mlsrpkpges evdllhfqsq flaagaapav qlvkkgnrgg gdansdrppl qdhrdvvmld
       61 nlpdlppalv psppkrarps pghclpeded peerlrrhdq hitavltkii erdtssvavn
      121 lpvpsgvafp avflrsrdtq gksatsgkrs ifaqeiaarr iaeakgpsvg evvpnvgppe
      181 gavtcetptp rnqgcqlpgs shsfqgpnlv tgkglrdqea eqeaqtihee niarlqamap
      241 eeilqeqqrl laqldpslva flrshshtqe qtgetaseeq rpggpsanvt keeplmsafa
      301 seprkrdkle peapalalpv tpqkewlhmd tveleklhwt qdlppvrrqq tqermqarfs
      361 lqgellapdv dlpthlglhh hgeeaeragy slqelfhltr sqvsqqrala lhvlaqvisr
      421 aqagefgdrl agsvlsllld agflfllrfs lddrvdgvia tairalrall vapgdeelld
      481 stfswyhgal tfplmpsqed kedededeec pagkakrksp eeesrpppdl arhdvikgll
      541 atsllprlry vlevtypgpa vvldilavli rlarhslesa trvlecprli etivreflpt
      601 swspvgagpt pslykvpcat amkllrvlas agrniaarll ssfdlrsrlc riiaeapqel
      661 alppeeaeml stealrlwav aasygqggyl yrelypvlmr alqvvprels thppqplsmq
      721 riaslltllt qltlaagstp aetisdsaea slsatpslvt wtqvsglqpl vepclrqtlk
      781 llsrpemwra vgpvpvacll flgayyqaws qqpsscpedw lqdmqrlsee lllpllsqpt
      841 lgslwdslrh csllcnplsc vpaleappsl vslgcsggcp rlslagsasp fpfltallsl
      901 lntlaqihkg lcgqlaaila apglqnyflq cvapgaaphl tpfsawalrh eyhlqylala
      961 laqkaaalqp lpathaalyh gmalallsrl lpgseylthe lllscvfrle flpertsggp
     1021 eaadfsdqls lgssrvprcg qgtllaqacq dlpsirncyl thcsparasl lasqalhrge
     1081 lqrvptlllp mptepllptd wpflplirly hrasdtpsgl sptdtmgtam rvlqwvlvle
     1141 swrpqalwav ppaarlarlm cvflvdself respvqhlva allaqlcqpq vlpnlnldcr
     1201 lpgltsfpdl yanfldhfea vsfgdhlfga lvllplqrrf svtlrlalfg ehvgalrals
     1261 lpltqlpvsl ecytvppedn lallqlyfrt lvtgalrprw cpvlyavava hvnsfifsqd
     1321 pqssdevkaa rrsmlqktwl ladeglrqhl lhyklpnstl pegfelysql pplrqhylqr
     1381 ltstvlqngv set
//
LOCUS       XP_047288330            1333 aa            linear   PRI 05-AUG-2025
DEFINITION  RNA polymerase II-associated protein 1 isoform X2 [Homo sapiens].
ACCESSION   XP_047288330
VERSION     XP_047288330.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432374.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1333
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1333
                     /product="RNA polymerase II-associated protein 1 isoform
                     X2"
                     /calculated_mol_wt=146082
     Region          225..>246
                     /region_name="RPAP1_N"
                     /note="RPAP1-like, N-terminal; pfam08621"
                     /db_xref="CDD:462539"
     Region          296..361
                     /region_name="RPAP1_C"
                     /note="RPAP1-like, C-terminal; pfam08620"
                     /db_xref="CDD:462538"
     CDS             1..1333
                     /gene="RPAP1"
                     /coded_by="XM_047432374.1:116..4117"
                     /db_xref="GeneID:26015"
                     /db_xref="HGNC:HGNC:24567"
                     /db_xref="MIM:611475"
ORIGIN      
        1 mlsrpkpges evdllhfqsq flaagaapav qlvkkgnrgg gdansdrppl qdhrdvvmld
       61 nlpdlppalv psppkrarps pghclpeded peerlrrhdq hitavltkii erdtssvavn
      121 lpvpsgvafp avflrsrdtq gksatsgkrs ifaqeiaarr iaeakgpsvg evvpnvgppe
      181 gavtcetptp rnqgcqlpgs shsfqgpnlv tgkglrdqea eqeaqtihee niarlqamap
      241 eeilqeqqrl laqlalalpv tpqkewlhmd tveleklhwt qdlppvrrqq tqermqarfs
      301 lqgellapdv dlpthlglhh hgeeaeragy slqelfhltr sqvsqqrala lhvlaqvisr
      361 aqagefgdrl agsvlsllld agflfllrfs lddrvdgvia tairalrall vapgdeelld
      421 stfswyhgal tfplmpsqed kedededeec pagkakrksp eeesrpppdl arhdvikgll
      481 atsllprlry vlevtypgpa vvldilavli rlarhslesa trvlecprli etivreflpt
      541 swspvgagpt pslykvpcat amkllrvlas agrniaarll ssfdlrsrlc riiaeapqel
      601 alppeeaeml stealrlwav aasygqggyl yrelypvlmr alqvvprels thppqplsmq
      661 riaslltllt qltlaagstp aetisdsaea slsatpslvt wtqvsglqpl vepclrqtlk
      721 llsrpemwra vgpvpvacll flgayyqaws qqpsscpedw lqdmqrlsee lllpllsqpt
      781 lgslwdslrh csllcnplsc vpaleappsl vslgcsggcp rlslagsasp fpfltallsl
      841 lntlaqihkg lcgqlaaila apglqnyflq cvapgaaphl tpfsawalrh eyhlqylala
      901 laqkaaalqp lpathaalyh gmalallsrl lpgseylthe lllscvfrle flpertsggp
      961 eaadfsdqls lgssrvprcg qgtllaqacq dlpsirncyl thcsparasl lasqalhrge
     1021 lqrvptlllp mptepllptd wpflplirly hrasdtpsgl sptdtmgtam rvlqwvlvle
     1081 swrpqalwav ppaarlarlm cvflvdself respvqhlva allaqlcqpq vlpnlnldcr
     1141 lpgltsfpdl yanfldhfea vsfgdhlfga lvllplqrrf svtlrlalfg ehvgalrals
     1201 lpltqlpvsl ecytvppedn lallqlyfrt lvtgalrprw cpvlyavava hvnsfifsqd
     1261 pqssdevkaa rrsmlqktwl ladeglrqhl lhyklpnstl pegfelysql pplrqhylqr
     1321 ltstvlqngv set
//
LOCUS       XP_047288331            1333 aa            linear   PRI 05-AUG-2025
DEFINITION  RNA polymerase II-associated protein 1 isoform X2 [Homo sapiens].
ACCESSION   XP_047288331
VERSION     XP_047288331.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432375.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1333
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1333
                     /product="RNA polymerase II-associated protein 1 isoform
                     X2"
                     /calculated_mol_wt=146082
     Region          225..>246
                     /region_name="RPAP1_N"
                     /note="RPAP1-like, N-terminal; pfam08621"
                     /db_xref="CDD:462539"
     Region          296..361
                     /region_name="RPAP1_C"
                     /note="RPAP1-like, C-terminal; pfam08620"
                     /db_xref="CDD:462538"
     CDS             1..1333
                     /gene="RPAP1"
                     /coded_by="XM_047432375.1:422..4423"
                     /db_xref="GeneID:26015"
                     /db_xref="HGNC:HGNC:24567"
                     /db_xref="MIM:611475"
ORIGIN      
        1 mlsrpkpges evdllhfqsq flaagaapav qlvkkgnrgg gdansdrppl qdhrdvvmld
       61 nlpdlppalv psppkrarps pghclpeded peerlrrhdq hitavltkii erdtssvavn
      121 lpvpsgvafp avflrsrdtq gksatsgkrs ifaqeiaarr iaeakgpsvg evvpnvgppe
      181 gavtcetptp rnqgcqlpgs shsfqgpnlv tgkglrdqea eqeaqtihee niarlqamap
      241 eeilqeqqrl laqlalalpv tpqkewlhmd tveleklhwt qdlppvrrqq tqermqarfs
      301 lqgellapdv dlpthlglhh hgeeaeragy slqelfhltr sqvsqqrala lhvlaqvisr
      361 aqagefgdrl agsvlsllld agflfllrfs lddrvdgvia tairalrall vapgdeelld
      421 stfswyhgal tfplmpsqed kedededeec pagkakrksp eeesrpppdl arhdvikgll
      481 atsllprlry vlevtypgpa vvldilavli rlarhslesa trvlecprli etivreflpt
      541 swspvgagpt pslykvpcat amkllrvlas agrniaarll ssfdlrsrlc riiaeapqel
      601 alppeeaeml stealrlwav aasygqggyl yrelypvlmr alqvvprels thppqplsmq
      661 riaslltllt qltlaagstp aetisdsaea slsatpslvt wtqvsglqpl vepclrqtlk
      721 llsrpemwra vgpvpvacll flgayyqaws qqpsscpedw lqdmqrlsee lllpllsqpt
      781 lgslwdslrh csllcnplsc vpaleappsl vslgcsggcp rlslagsasp fpfltallsl
      841 lntlaqihkg lcgqlaaila apglqnyflq cvapgaaphl tpfsawalrh eyhlqylala
      901 laqkaaalqp lpathaalyh gmalallsrl lpgseylthe lllscvfrle flpertsggp
      961 eaadfsdqls lgssrvprcg qgtllaqacq dlpsirncyl thcsparasl lasqalhrge
     1021 lqrvptlllp mptepllptd wpflplirly hrasdtpsgl sptdtmgtam rvlqwvlvle
     1081 swrpqalwav ppaarlarlm cvflvdself respvqhlva allaqlcqpq vlpnlnldcr
     1141 lpgltsfpdl yanfldhfea vsfgdhlfga lvllplqrrf svtlrlalfg ehvgalrals
     1201 lpltqlpvsl ecytvppedn lallqlyfrt lvtgalrprw cpvlyavava hvnsfifsqd
     1261 pqssdevkaa rrsmlqktwl ladeglrqhl lhyklpnstl pegfelysql pplrqhylqr
     1321 ltstvlqngv set
//
LOCUS       XP_047288332             645 aa            linear   PRI 05-AUG-2025
DEFINITION  D-glucuronyl C5-epimerase isoform X1 [Homo sapiens].
ACCESSION   XP_047288332
VERSION     XP_047288332.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432376.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..645
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..645
                     /product="D-glucuronyl C5-epimerase isoform X1"
                     /calculated_mol_wt=73528
     Region          444..635
                     /region_name="C5-epim_C"
                     /note="D-glucuronyl C5-epimerase C-terminus; pfam06662"
                     /db_xref="CDD:461978"
     CDS             1..645
                     /gene="GLCE"
                     /gene_synonym="HSEPI"
                     /coded_by="XM_047432376.1:990..2927"
                     /db_xref="GeneID:26035"
                     /db_xref="HGNC:HGNC:17855"
                     /db_xref="MIM:612134"
ORIGIN      
        1 mtrnenyirw kfastkinee pwkwyglnmr claarvnykt liiicalftl vtvllwnkcs
       61 sdkaiqfprr sssgfrvdgf ekraaasesn nymnhvakqq seeafpqeqq kappvvggfn
      121 snvgskvlgl kyeeidclin dehtikgrre gnevflpftw vekyfdvygk vvqydgydrf
      181 efshsyskvy aqrapyhpdg vfmsfegynv evrdrvkcis gvegvplstq wgpqgyfypi
      241 qiaqyglshy sknltekpph ievyetaedr dknkpndwtv pkgcfmanva dksrftnvkq
      301 fiapetsegv slqlgntkdf iisfdlkflt ngsvsvvlet teknqlftih yvsnaqliaf
      361 kerdiyygig prtswstvtr dlvtdlrkgv glsntkavkp tkimpkkvvr liakgkgfld
      421 nitisttahm aaffaasdwl vrnqdekggw pimvtrklge gfkslepgwy samaqgqais
      481 tlvraylltk dhiflnsalr atapykflse qhgvkavfmn khdwyeeypt tpssfvlngf
      541 mysliglydl ketageklgk earslyergm eslkamlply dtgsgtiydl rhfmlgiapn
      601 larwdyhtth inqlqllsti despvfkefv krwksylkgs rakhn
//
LOCUS       XP_047288333             645 aa            linear   PRI 05-AUG-2025
DEFINITION  D-glucuronyl C5-epimerase isoform X1 [Homo sapiens].
ACCESSION   XP_047288333
VERSION     XP_047288333.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432377.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..645
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..645
                     /product="D-glucuronyl C5-epimerase isoform X1"
                     /calculated_mol_wt=73528
     Region          444..635
                     /region_name="C5-epim_C"
                     /note="D-glucuronyl C5-epimerase C-terminus; pfam06662"
                     /db_xref="CDD:461978"
     CDS             1..645
                     /gene="GLCE"
                     /gene_synonym="HSEPI"
                     /coded_by="XM_047432377.1:1462..3399"
                     /db_xref="GeneID:26035"
                     /db_xref="HGNC:HGNC:17855"
                     /db_xref="MIM:612134"
ORIGIN      
        1 mtrnenyirw kfastkinee pwkwyglnmr claarvnykt liiicalftl vtvllwnkcs
       61 sdkaiqfprr sssgfrvdgf ekraaasesn nymnhvakqq seeafpqeqq kappvvggfn
      121 snvgskvlgl kyeeidclin dehtikgrre gnevflpftw vekyfdvygk vvqydgydrf
      181 efshsyskvy aqrapyhpdg vfmsfegynv evrdrvkcis gvegvplstq wgpqgyfypi
      241 qiaqyglshy sknltekpph ievyetaedr dknkpndwtv pkgcfmanva dksrftnvkq
      301 fiapetsegv slqlgntkdf iisfdlkflt ngsvsvvlet teknqlftih yvsnaqliaf
      361 kerdiyygig prtswstvtr dlvtdlrkgv glsntkavkp tkimpkkvvr liakgkgfld
      421 nitisttahm aaffaasdwl vrnqdekggw pimvtrklge gfkslepgwy samaqgqais
      481 tlvraylltk dhiflnsalr atapykflse qhgvkavfmn khdwyeeypt tpssfvlngf
      541 mysliglydl ketageklgk earslyergm eslkamlply dtgsgtiydl rhfmlgiapn
      601 larwdyhtth inqlqllsti despvfkefv krwksylkgs rakhn
//
LOCUS       XP_047288335             645 aa            linear   PRI 05-AUG-2025
DEFINITION  D-glucuronyl C5-epimerase isoform X1 [Homo sapiens].
ACCESSION   XP_047288335
VERSION     XP_047288335.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432379.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..645
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..645
                     /product="D-glucuronyl C5-epimerase isoform X1"
                     /calculated_mol_wt=73528
     Region          444..635
                     /region_name="C5-epim_C"
                     /note="D-glucuronyl C5-epimerase C-terminus; pfam06662"
                     /db_xref="CDD:461978"
     CDS             1..645
                     /gene="GLCE"
                     /gene_synonym="HSEPI"
                     /coded_by="XM_047432379.1:9648..11585"
                     /db_xref="GeneID:26035"
                     /db_xref="HGNC:HGNC:17855"
                     /db_xref="MIM:612134"
ORIGIN      
        1 mtrnenyirw kfastkinee pwkwyglnmr claarvnykt liiicalftl vtvllwnkcs
       61 sdkaiqfprr sssgfrvdgf ekraaasesn nymnhvakqq seeafpqeqq kappvvggfn
      121 snvgskvlgl kyeeidclin dehtikgrre gnevflpftw vekyfdvygk vvqydgydrf
      181 efshsyskvy aqrapyhpdg vfmsfegynv evrdrvkcis gvegvplstq wgpqgyfypi
      241 qiaqyglshy sknltekpph ievyetaedr dknkpndwtv pkgcfmanva dksrftnvkq
      301 fiapetsegv slqlgntkdf iisfdlkflt ngsvsvvlet teknqlftih yvsnaqliaf
      361 kerdiyygig prtswstvtr dlvtdlrkgv glsntkavkp tkimpkkvvr liakgkgfld
      421 nitisttahm aaffaasdwl vrnqdekggw pimvtrklge gfkslepgwy samaqgqais
      481 tlvraylltk dhiflnsalr atapykflse qhgvkavfmn khdwyeeypt tpssfvlngf
      541 mysliglydl ketageklgk earslyergm eslkamlply dtgsgtiydl rhfmlgiapn
      601 larwdyhtth inqlqllsti despvfkefv krwksylkgs rakhn
//
LOCUS       XP_016877562             623 aa            linear   PRI 05-AUG-2025
DEFINITION  D-glucuronyl C5-epimerase isoform X2 [Homo sapiens].
ACCESSION   XP_016877562
VERSION     XP_016877562.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022073.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..623
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..623
                     /product="D-glucuronyl C5-epimerase isoform X2"
                     /calculated_mol_wt=70705
     Region          422..613
                     /region_name="C5-epim_C"
                     /note="D-glucuronyl C5-epimerase C-terminus; pfam06662"
                     /db_xref="CDD:461978"
     CDS             1..623
                     /gene="GLCE"
                     /gene_synonym="HSEPI"
                     /coded_by="XM_017022073.2:317..2188"
                     /db_xref="GeneID:26035"
                     /db_xref="HGNC:HGNC:17855"
                     /db_xref="MIM:612134"
ORIGIN      
        1 mryglnmrcl aarvnyktli iicalftlvt vllwnkcssd kaiqfprrss sgfrvdgfek
       61 raaasesnny mnhvakqqse eafpqeqqka ppvvggfnsn vgskvlglky eeidclinde
      121 htikgrregn evflpftwve kyfdvygkvv qydgydrfef shsyskvyaq rapyhpdgvf
      181 msfegynvev rdrvkcisgv egvplstqwg pqgyfypiqi aqyglshysk nltekpphie
      241 vyetaedrdk nkpndwtvpk gcfmanvadk srftnvkqfi apetsegvsl qlgntkdfii
      301 sfdlkfltng svsvvlette knqlftihyv snaqliafke rdiyygigpr tswstvtrdl
      361 vtdlrkgvgl sntkavkptk impkkvvrli akgkgfldni tisttahmaa ffaasdwlvr
      421 nqdekggwpi mvtrklgegf kslepgwysa maqgqaistl vraylltkdh iflnsalrat
      481 apykflseqh gvkavfmnkh dwyeeypttp ssfvlngfmy sliglydlke tageklgkea
      541 rslyergmes lkamlplydt gsgtiydlrh fmlgiapnla rwdyhtthin qlqllstide
      601 spvfkefvkr wksylkgsra khn
//
LOCUS       XP_047288336             305 aa            linear   PRI 05-AUG-2025
DEFINITION  D-glucuronyl C5-epimerase isoform X3 [Homo sapiens].
ACCESSION   XP_047288336
VERSION     XP_047288336.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432380.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..305
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..305
                     /product="D-glucuronyl C5-epimerase isoform X3"
                     /calculated_mol_wt=35110
     CDS             1..305
                     /gene="GLCE"
                     /gene_synonym="HSEPI"
                     /coded_by="XM_047432380.1:990..1907"
                     /db_xref="GeneID:26035"
                     /db_xref="HGNC:HGNC:17855"
                     /db_xref="MIM:612134"
ORIGIN      
        1 mtrnenyirw kfastkinee pwkwyglnmr claarvnykt liiicalftl vtvllwnkcs
       61 sdkaiqfprr sssgfrvdgf ekraaasesn nymnhvakqq seeafpqeqq kappvvggfn
      121 snvgskvlgl kyeeidclin dehtikgrre gnevflpftw vekyfdvygk vvqydgydrf
      181 efshsyskvy aqrapyhpdg vfmsfegynv evrdrvkcis gvegvplstq wgpqgyfypi
      241 qiaqyglshy sknltekpph ievyetaedr dknkpndwtv pkgcfmanva dksrftnvkq
      301 fiapv
//
LOCUS       XP_016877563             283 aa            linear   PRI 05-AUG-2025
DEFINITION  D-glucuronyl C5-epimerase isoform X4 [Homo sapiens].
ACCESSION   XP_016877563
VERSION     XP_016877563.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022074.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..283
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..283
                     /product="D-glucuronyl C5-epimerase isoform X4"
                     /calculated_mol_wt=32287
     CDS             1..283
                     /gene="GLCE"
                     /gene_synonym="HSEPI"
                     /coded_by="XM_017022074.3:232..1083"
                     /db_xref="GeneID:26035"
                     /db_xref="HGNC:HGNC:17855"
                     /db_xref="MIM:612134"
ORIGIN      
        1 mryglnmrcl aarvnyktli iicalftlvt vllwnkcssd kaiqfprrss sgfrvdgfek
       61 raaasesnny mnhvakqqse eafpqeqqka ppvvggfnsn vgskvlglky eeidclinde
      121 htikgrregn evflpftwve kyfdvygkvv qydgydrfef shsyskvyaq rapyhpdgvf
      181 msfegynvev rdrvkcisgv egvplstqwg pqgyfypiqi aqyglshysk nltekpphie
      241 vyetaedrdk nkpndwtvpk gcfmanvadk srftnvkqfi apv
//
LOCUS       XP_047288337             314 aa            linear   PRI 05-AUG-2025
DEFINITION  pygopus homolog 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047288337
VERSION     XP_047288337.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432381.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..314
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..314
                     /product="pygopus homolog 1 isoform X1"
                     /calculated_mol_wt=34054
     Region          <40..>252
                     /region_name="PTZ00395"
                     /note="Sec24-related protein; Provisional"
                     /db_xref="CDD:185594"
     Region          236..292
                     /region_name="PHD_PYGO1"
                     /note="PHD finger found in pygopus homolog 1 (PYGO1);
                     cd15635"
                     /db_xref="CDD:277105"
     Site            order(236,245..247,249,251..253,255,261,274,277..278,280,
                     283)
                     /site_type="other"
                     /note="H3K4me binding site [polypeptide binding]"
                     /db_xref="CDD:277105"
     Site            order(267..270,273,276..277,280,282..286,291)
                     /site_type="other"
                     /note="BCL9 HD1 interface [polypeptide binding]"
                     /db_xref="CDD:277105"
     CDS             1..314
                     /gene="PYGO1"
                     /coded_by="XM_047432381.1:424..1368"
                     /db_xref="GeneID:26108"
                     /db_xref="HGNC:HGNC:30256"
                     /db_xref="MIM:606902"
ORIGIN      
        1 mpphvpprms spycgpyslr nqphpfpqnp lgmgfnrpha fnfgphdnss fgnpsynnal
       61 sqnvnmpnqh frqnpaenfs qippqnasqv snpdlasnfv pgnnsnftsp lesnhsfipp
      121 pntfgqakap ppkqdftqga tkntnqnssa hpphlnmddt vnqsnielkn vnrnnavnqe
      181 nsrsssteat nnnpangtqn kprqprgaad actteksnks slhpnrhghs ssdpvypcgi
      241 ctnevnddqd ailceascqk wfhrictgmt etayglltae asavwgcdtc madkdvqlmr
      301 tretfgpsav gsda
//
LOCUS       XP_047288338             299 aa            linear   PRI 05-AUG-2025
DEFINITION  F-box only protein 22 isoform X1 [Homo sapiens].
ACCESSION   XP_047288338
VERSION     XP_047288338.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432382.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..299
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..299
                     /product="F-box only protein 22 isoform X1"
                     /calculated_mol_wt=32785
     Region          <194..292
                     /region_name="FIST"
                     /note="Small ligand-binding sensory domain FIST [Signal
                     transduction mechanisms]; COG4398"
                     /db_xref="CDD:443524"
     CDS             1..299
                     /gene="FBXO22"
                     /gene_synonym="FBX22; FISTC1; TYMAS"
                     /coded_by="XM_047432382.1:116..1015"
                     /db_xref="GeneID:26263"
                     /db_xref="HGNC:HGNC:13593"
                     /db_xref="MIM:609096"
ORIGIN      
        1 madsetfisl eecrghkrar krtsmetala leklfpkqcq vlgivtpgiv vtpmgsgsnr
       61 pqeieigesg fallfpqieg ikiqpfhfik dpknltlerh qltevglldn pelrvvlvfg
      121 yncckvgasn ylqqvvstfs dmniilaggq vdnlssltse knpldidasg vvglsfsghr
      181 iqsatvllne dvsdektaea amqrlkaani pehntigfmf acvgrgfqyy rakgnveada
      241 frkffpsvpl fgffgngeig cdrivtgnfi lrkcnevkdd dlfhsyttim alihlgssk
//
LOCUS       XP_047288339             526 aa            linear   PRI 05-AUG-2025
DEFINITION  vacuolar protein sorting-associated protein 33B isoform X1 [Homo
            sapiens].
ACCESSION   XP_047288339
VERSION     XP_047288339.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432383.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..526
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..526
                     /product="vacuolar protein sorting-associated protein 33B
                     isoform X1"
                     /calculated_mol_wt=59901
     Region          12..519
                     /region_name="Sec1"
                     /note="Sec1 family; pfam00995"
                     /db_xref="CDD:460020"
     CDS             1..526
                     /gene="VPS33B"
                     /gene_synonym="KDIDAR; PFIC12"
                     /coded_by="XM_047432383.1:209..1789"
                     /db_xref="GeneID:26276"
                     /db_xref="HGNC:HGNC:12712"
                     /db_xref="MIM:608552"
ORIGIN      
        1 mryiaslvna dklagrtrky kvifspqkfy acemvleeeg iygdvscdew afsllpldvd
       61 llsmelpeff rdyflegdqr wintvaqalh llstlygpfp ncygigrcak mayelwrnle
      121 eeedgetkgr rpeighifll drdvdfvtal csqvvyeglv ddtfrikcgs vdfgpevtss
      181 dkslkvllna edkvfneirn ehfsnvfgfl sqkarnlqaq ydrrrgmdik qmknfvsqel
      241 kglkqehrll slhigacesi mkkktkqdfq eliktehall egfnirests yieehidrqv
      301 spieslrlmc llsitengli pkdyrslktq ylqsygpehl ltfsnlrrag llteqapgdt
      361 ltaveskvsk lvtdkaagki tdafsslakr snfraiskkl nliprvdgey dlkvprdmay
      421 vfggayvpls criieqvler rswqgldevv rllncsdfaf tdmtkedkas seslrlilvv
      481 flggctfsei salrflgrek gyrfifltta vtnsarlmea msevka
//
LOCUS       XP_005254944             526 aa            linear   PRI 05-AUG-2025
DEFINITION  vacuolar protein sorting-associated protein 33B isoform X1 [Homo
            sapiens].
ACCESSION   XP_005254944
VERSION     XP_005254944.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254887.2
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 26% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..526
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..526
                     /product="vacuolar protein sorting-associated protein 33B
                     isoform X1"
                     /calculated_mol_wt=59901
     Region          12..519
                     /region_name="Sec1"
                     /note="Sec1 family; pfam00995"
                     /db_xref="CDD:460020"
     CDS             1..526
                     /gene="VPS33B"
                     /gene_synonym="KDIDAR; PFIC12"
                     /coded_by="XM_005254887.2:503..2083"
                     /db_xref="GeneID:26276"
                     /db_xref="HGNC:HGNC:12712"
                     /db_xref="MIM:608552"
ORIGIN      
        1 mryiaslvna dklagrtrky kvifspqkfy acemvleeeg iygdvscdew afsllpldvd
       61 llsmelpeff rdyflegdqr wintvaqalh llstlygpfp ncygigrcak mayelwrnle
      121 eeedgetkgr rpeighifll drdvdfvtal csqvvyeglv ddtfrikcgs vdfgpevtss
      181 dkslkvllna edkvfneirn ehfsnvfgfl sqkarnlqaq ydrrrgmdik qmknfvsqel
      241 kglkqehrll slhigacesi mkkktkqdfq eliktehall egfnirests yieehidrqv
      301 spieslrlmc llsitengli pkdyrslktq ylqsygpehl ltfsnlrrag llteqapgdt
      361 ltaveskvsk lvtdkaagki tdafsslakr snfraiskkl nliprvdgey dlkvprdmay
      421 vfggayvpls criieqvler rswqgldevv rllncsdfaf tdmtkedkas seslrlilvv
      481 flggctfsei salrflgrek gyrfifltta vtnsarlmea msevka
//
LOCUS       XP_011519751             509 aa            linear   PRI 05-AUG-2025
DEFINITION  vacuolar protein sorting-associated protein 33B isoform X2 [Homo
            sapiens].
ACCESSION   XP_011519751
VERSION     XP_011519751.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521449.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..509
                     /product="vacuolar protein sorting-associated protein 33B
                     isoform X2"
                     /calculated_mol_wt=57842
     Region          30..502
                     /region_name="Sec1"
                     /note="Sec1 family; pfam00995"
                     /db_xref="CDD:460020"
     CDS             1..509
                     /gene="VPS33B"
                     /gene_synonym="KDIDAR; PFIC12"
                     /coded_by="XM_011521449.3:16..1545"
                     /db_xref="GeneID:26276"
                     /db_xref="HGNC:HGNC:12712"
                     /db_xref="MIM:608552"
ORIGIN      
        1 mnphrvllps pdsppssqrd fthafpdvsc dewafsllpl dvdllsmelp effrdyfleg
       61 dqrwintvaq alhllstlyg pfpncygigr cakmayelwr nleeeedget kgrrpeighi
      121 flldrdvdfv talcsqvvye glvddtfrik cgsvdfgpev tssdkslkvl lnaedkvfne
      181 irnehfsnvf gflsqkarnl qaqydrrrgm dikqmknfvs qelkglkqeh rllslhigac
      241 esimkkktkq dfqelikteh allegfnire stsyieehid rqvspieslr lmcllsiten
      301 glipkdyrsl ktqylqsygp ehlltfsnlr ragllteqap gdtltavesk vsklvtdkaa
      361 gkitdafssl akrsnfrais kklnliprvd geydlkvprd mayvfggayv plscriieqv
      421 lerrswqgld evvrllncsd faftdmtked kasseslrli lvvflggctf seisalrflg
      481 rekgyrfifl ttavtnsarl meamsevka
//
LOCUS       XP_047288340             386 aa            linear   PRI 05-AUG-2025
DEFINITION  vacuolar protein sorting-associated protein 33B isoform X3 [Homo
            sapiens].
ACCESSION   XP_047288340
VERSION     XP_047288340.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432384.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 1% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..386
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..386
                     /product="vacuolar protein sorting-associated protein 33B
                     isoform X3"
                     /calculated_mol_wt=44513
     Region          37..>368
                     /region_name="Sec1"
                     /note="Sec1 family; pfam00995"
                     /db_xref="CDD:460020"
     CDS             1..386
                     /gene="VPS33B"
                     /gene_synonym="KDIDAR; PFIC12"
                     /coded_by="XM_047432384.1:373..1533"
                     /db_xref="GeneID:26276"
                     /db_xref="HGNC:HGNC:12712"
                     /db_xref="MIM:608552"
ORIGIN      
        1 mafphrpdap elpdfsmlkr lardqliyll eqlpgkkdlf ieadlmspld rianvsilkq
       61 hevdklykve nkpalssneq lcflvrprik nmryiaslvn adklagrtrk ykvifspqkf
      121 yacemvleee giygdvscde wafsllpldv dllsmelpef frdyflegdq rwintvaqal
      181 hllstlygpf pncygigrca kmayelwrnl eeeedgetkg rrpeighifl ldrdvdfvta
      241 lcsqvvyegl vddtfrikcg svdfgpevts sdkslkvlln aedkvfneir nehfsnvfgf
      301 lsqkarnlqa qydrrrgmdi kqmknfvsqe lkglkqehrl lslhigaces imkkktkqdf
      361 qeliktehad tgyvecwfll evlgvp
//
LOCUS       XP_047288341             476 aa            linear   PRI 05-AUG-2025
DEFINITION  glycine amidinotransferase, mitochondrial isoform X1 [Homo
            sapiens].
ACCESSION   XP_047288341
VERSION     XP_047288341.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432385.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..476
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..476
                     /product="glycine amidinotransferase, mitochondrial
                     isoform X1"
                     /calculated_mol_wt=54067
     Region          118..468
                     /region_name="amidinotransferase_AGAT-like"
                     /note="L-arginine:glycine amidinotransferase and similar
                     proteins; cd21136"
                     /db_xref="CDD:439148"
     Site            order(220,222..223,309,356,358..359,375,407..408,414,455,
                     459..460)
                     /site_type="other"
                     /note="chemical substrate binding site [chemical binding]"
                     /db_xref="CDD:439148"
     CDS             1..476
                     /gene="GATM"
                     /gene_synonym="AGAT; AT; CCDS3; FRTS; FRTS1; RFS"
                     /coded_by="XM_047432385.1:1597..3027"
                     /db_xref="GeneID:2628"
                     /db_xref="HGNC:HGNC:4175"
                     /db_xref="MIM:602360"
ORIGIN      
        1 mgprgaagae rgykrprapr arpprsgral gkawtdaaqr pgtfrawtsr aramlrvrcl
       61 rggsrgaeav hyigsrlgrt ltgwvqrtfq stqaatassr nscaaddkat eplpkdcpvs
      121 synewdplee vivgraenac vppftievka ntyekywpfy qkqgghyfpk dhlkkavaei
      181 eemcnilkte gvtvrrpdpi dwslkyktpd festglysam prdilivvgn eiieapmawr
      241 srffeyrayr siikdyfhrg akwttapkpt madelynqdy pihsvedrhk laaqgkfvtt
      301 efepcfdaad firagrdifa qrsqvtnylg iewmrrhlap dyrvhiisfk dpnpmhidat
      361 fniigpgivl snpdrpchqi dlfkkagwti itpptpiipd dhplwmsskw lsmnvlmlde
      421 krvmvdanev piqkmfeklg ittikvnirn anslgggfhc wtcdvrrrgt lqsyld
//
LOCUS       XP_047288342             439 aa            linear   PRI 05-AUG-2025
DEFINITION  glycine amidinotransferase, mitochondrial isoform X2 [Homo
            sapiens].
ACCESSION   XP_047288342
VERSION     XP_047288342.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432386.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..439
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..439
                     /product="glycine amidinotransferase, mitochondrial
                     isoform X2"
                     /calculated_mol_wt=50136
     Region          81..431
                     /region_name="amidinotransferase_AGAT-like"
                     /note="L-arginine:glycine amidinotransferase and similar
                     proteins; cd21136"
                     /db_xref="CDD:439148"
     Site            order(183,185..186,272,319,321..322,338,370..371,377,418,
                     422..423)
                     /site_type="other"
                     /note="chemical substrate binding site [chemical binding]"
                     /db_xref="CDD:439148"
     CDS             1..439
                     /gene="GATM"
                     /gene_synonym="AGAT; AT; CCDS3; FRTS; FRTS1; RFS"
                     /coded_by="XM_047432386.1:510..1829"
                     /db_xref="GeneID:2628"
                     /db_xref="HGNC:HGNC:4175"
                     /db_xref="MIM:602360"
ORIGIN      
        1 mlfvfkklte vlfrrstsla alstlresdl rggcilllgl grtltgwvqr tfqstqaata
       61 ssrnscaadd kateplpkdc pvssynewdp leevivgrae nacvppftie vkantyekyw
      121 pfyqkqgghy fpkdhlkkav aeieemcnil ktegvtvrrp dpidwslkyk tpdfestgly
      181 samprdiliv vgneiieapm awrsrffeyr ayrsiikdyf hrgakwttap kptmadelyn
      241 qdypihsved rhklaaqgkf vttefepcfd aadfiragrd ifaqrsqvtn ylgiewmrrh
      301 lapdyrvhii sfkdpnpmhi datfniigpg ivlsnpdrpc hqidlfkkag wtiitpptpi
      361 ipddhplwms skwlsmnvlm ldekrvmvda nevpiqkmfe klgittikvn irnanslggg
      421 fhcwtcdvrr rgtlqsyld
//
LOCUS       XP_047288343             439 aa            linear   PRI 05-AUG-2025
DEFINITION  glycine amidinotransferase, mitochondrial isoform X2 [Homo
            sapiens].
ACCESSION   XP_047288343
VERSION     XP_047288343.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432387.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..439
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..439
                     /product="glycine amidinotransferase, mitochondrial
                     isoform X2"
                     /calculated_mol_wt=50136
     Region          81..431
                     /region_name="amidinotransferase_AGAT-like"
                     /note="L-arginine:glycine amidinotransferase and similar
                     proteins; cd21136"
                     /db_xref="CDD:439148"
     Site            order(183,185..186,272,319,321..322,338,370..371,377,418,
                     422..423)
                     /site_type="other"
                     /note="chemical substrate binding site [chemical binding]"
                     /db_xref="CDD:439148"
     CDS             1..439
                     /gene="GATM"
                     /gene_synonym="AGAT; AT; CCDS3; FRTS; FRTS1; RFS"
                     /coded_by="XM_047432387.1:470..1789"
                     /db_xref="GeneID:2628"
                     /db_xref="HGNC:HGNC:4175"
                     /db_xref="MIM:602360"
ORIGIN      
        1 mlfvfkklte vlfrrstsla alstlresdl rggcilllgl grtltgwvqr tfqstqaata
       61 ssrnscaadd kateplpkdc pvssynewdp leevivgrae nacvppftie vkantyekyw
      121 pfyqkqgghy fpkdhlkkav aeieemcnil ktegvtvrrp dpidwslkyk tpdfestgly
      181 samprdiliv vgneiieapm awrsrffeyr ayrsiikdyf hrgakwttap kptmadelyn
      241 qdypihsved rhklaaqgkf vttefepcfd aadfiragrd ifaqrsqvtn ylgiewmrrh
      301 lapdyrvhii sfkdpnpmhi datfniigpg ivlsnpdrpc hqidlfkkag wtiitpptpi
      361 ipddhplwms skwlsmnvlm ldekrvmvda nevpiqkmfe klgittikvn irnanslggg
      421 fhcwtcdvrr rgtlqsyld
//
LOCUS       XP_047288344             294 aa            linear   PRI 05-AUG-2025
DEFINITION  glycine amidinotransferase, mitochondrial isoform X3 [Homo
            sapiens].
ACCESSION   XP_047288344
VERSION     XP_047288344.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432388.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..294
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..294
                     /product="glycine amidinotransferase, mitochondrial
                     isoform X3"
                     /calculated_mol_wt=33862
     Region          1..286
                     /region_name="amidinotransferase_AGAT-like"
                     /note="L-arginine:glycine amidinotransferase and similar
                     proteins; cd21136"
                     /db_xref="CDD:439148"
     Site            order(38,40..41,127,174,176..177,193,225..226,232,273,
                     277..278)
                     /site_type="other"
                     /note="chemical substrate binding site [chemical binding]"
                     /db_xref="CDD:439148"
     CDS             1..294
                     /gene="GATM"
                     /gene_synonym="AGAT; AT; CCDS3; FRTS; FRTS1; RFS"
                     /coded_by="XM_047432388.1:744..1628"
                     /db_xref="GeneID:2628"
                     /db_xref="HGNC:HGNC:4175"
                     /db_xref="MIM:602360"
ORIGIN      
        1 mcnilktegv tvrrpdpidw slkyktpdfe stglysampr dilivvgnei ieapmawrsr
       61 ffeyrayrsi ikdyfhrgak wttapkptma delynqdypi hsvedrhkla aqgkfvttef
      121 epcfdaadfi ragrdifaqr sqvtnylgie wmrrhlapdy rvhiisfkdp npmhidatfn
      181 iigpgivlsn pdrpchqidl fkkagwtiit pptpiipddh plwmsskwls mnvlmldekr
      241 vmvdanevpi qkmfeklgit tikvnirnan slgggfhcwt cdvrrrgtlq syld
//
LOCUS       XP_047288345             260 aa            linear   PRI 05-AUG-2025
DEFINITION  neuroplastin isoform X1 [Homo sapiens].
ACCESSION   XP_047288345
VERSION     XP_047288345.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432389.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..260
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..260
                     /product="neuroplastin isoform X1"
                     /calculated_mol_wt=28649
     Region          52..103
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          64..69
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409408"
     Region          85..89
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409408"
     Region          99..103
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409408"
     Region          129..217
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          139..143
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          152..158
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          181..186
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          197..202
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          210..213
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     CDS             1..260
                     /gene="NPTN"
                     /gene_synonym="GP55; GP65; np55; np65; SDFR1; SDR1"
                     /coded_by="XM_047432389.1:175..957"
                     /db_xref="GeneID:27020"
                     /db_xref="HGNC:HGNC:17867"
                     /db_xref="MIM:612820"
ORIGIN      
        1 msgsslpsal alslllvsgs llpgpgaaqn eprivtseev iirdspvlpv tlqcnltsss
       61 htltysywtk ngvelsatrk nasnmeyrin kpraedsgey hcvyhfvsap kanatievka
      121 apditghkrs enknegqdat mycksvgyph pdwiwrkken gmpmdivnts grffiinken
      181 ytelnivnlq itedpgeyec natnaigsas vvtvlrvrsh laplwpflgi laeiiilvvi
      241 ivvyekrkrp devpddhqad
//
LOCUS       XP_047288346             650 aa            linear   PRI 05-AUG-2025
DEFINITION  gamma-tubulin complex component 4 isoform X1 [Homo sapiens].
ACCESSION   XP_047288346
VERSION     XP_047288346.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432390.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..650
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..650
                     /product="gamma-tubulin complex component 4 isoform X1"
                     /calculated_mol_wt=73937
     Region          2..338
                     /region_name="GCP_N_terminal"
                     /note="Gamma tubulin complex component N-terminal;
                     pfam17681"
                     /db_xref="CDD:465456"
     Region          339..638
                     /region_name="GCP_C_terminal"
                     /note="Gamma tubulin complex component C-terminal;
                     pfam04130"
                     /db_xref="CDD:461187"
     CDS             1..650
                     /gene="TUBGCP4"
                     /gene_synonym="76P; GCP-4; GCP4; Grip76; MCCRP3"
                     /coded_by="XM_047432390.1:255..2207"
                     /db_xref="GeneID:27229"
                     /db_xref="HGNC:HGNC:16691"
                     /db_xref="MIM:609610"
ORIGIN      
        1 mihelllals gypgsiftwn krsglqvsqd fpflhpsets vlnrlcrlgt dyirftefie
       61 qytghvqqqd hhpsqqgqgg lhgiylrafc tgldsvlqpy rqalldleqe flgdphlsis
      121 hvnyfldqfq llfpsvmvvv eqiksqkihg cqiletvykh scgglppvrs alekilavch
      181 gvmykqlsaw mlhgllldqh eeffikqgps sgnvsaqpee deedlgiggl tgkqlrelqd
      241 lrlieeenml apslkqfslr veilpsyipv rvaekilfvg esvqmfenqn vnltrkgsil
      301 knqedtfaae lhrlkqqplf slvdfeqvvd rirstvaeii kdfyllgrge lfqafidtaq
      361 hmlktpptav tehdvnvafq qsahkvlldd dnllpllhlt ieyhgkehka datqaregps
      421 retspreapa sgwaalglsy kvqwplhilf tpavlekynv vfkyllsvrr vqaelqhcwa
      481 lqmqrkhlks nqtdaikwrl rnhmaflvdn lqyylqvdvl esqfsqllhq instrdfesi
      541 rlahdhflsn llaqsfillk pvfhclneil dlchsfcslv sqnlgplder gaaqlsilvk
      601 gfsrqssllf kilssvrnhq insdlaqlll rldynkyytq aggtlgsfgm
//
LOCUS       XP_047288347             649 aa            linear   PRI 05-AUG-2025
DEFINITION  gamma-tubulin complex component 4 isoform X2 [Homo sapiens].
ACCESSION   XP_047288347
VERSION     XP_047288347.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432391.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..649
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..649
                     /product="gamma-tubulin complex component 4 isoform X2"
                     /calculated_mol_wt=73866
     Region          2..338
                     /region_name="GCP_N_terminal"
                     /note="Gamma tubulin complex component N-terminal;
                     pfam17681"
                     /db_xref="CDD:465456"
     Region          339..637
                     /region_name="GCP_C_terminal"
                     /note="Gamma tubulin complex component C-terminal;
                     pfam04130"
                     /db_xref="CDD:461187"
     CDS             1..649
                     /gene="TUBGCP4"
                     /gene_synonym="76P; GCP-4; GCP4; Grip76; MCCRP3"
                     /coded_by="XM_047432391.1:255..2204"
                     /db_xref="GeneID:27229"
                     /db_xref="HGNC:HGNC:16691"
                     /db_xref="MIM:609610"
ORIGIN      
        1 mihelllals gypgsiftwn krsglqvsqd fpflhpsets vlnrlcrlgt dyirftefie
       61 qytghvqqqd hhpsqqgqgg lhgiylrafc tgldsvlqpy rqalldleqe flgdphlsis
      121 hvnyfldqfq llfpsvmvvv eqiksqkihg cqiletvykh scgglppvrs alekilavch
      181 gvmykqlsaw mlhgllldqh eeffikqgps sgnvsaqpee deedlgiggl tgkqlrelqd
      241 lrlieeenml apslkqfslr veilpsyipv rvaekilfvg esvqmfenqn vnltrkgsil
      301 knqedtfaae lhrlkqqplf slvdfeqvvd rirstvaeii kdfyllgrge lfqafidtaq
      361 hmlktpptav tehdvnvafq qsahkvlldd dnllpllhlt ieyhgkehkd atqaregpsr
      421 etspreapas gwaalglsyk vqwplhilft pavlekynvv fkyllsvrrv qaelqhcwal
      481 qmqrkhlksn qtdaikwrlr nhmaflvdnl qyylqvdvle sqfsqllhqi nstrdfesir
      541 lahdhflsnl laqsfillkp vfhclneild lchsfcslvs qnlgplderg aaqlsilvkg
      601 fsrqssllfk ilssvrnhqi nsdlaqlllr ldynkyytqa ggtlgsfgm
//
LOCUS       XP_011519756             628 aa            linear   PRI 05-AUG-2025
DEFINITION  gamma-tubulin complex component 4 isoform X3 [Homo sapiens].
ACCESSION   XP_011519756
VERSION     XP_011519756.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521454.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..628
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..628
                     /product="gamma-tubulin complex component 4 isoform X3"
                     /calculated_mol_wt=71692
     Region          2..347
                     /region_name="GCP_N_terminal"
                     /note="Gamma tubulin complex component N-terminal;
                     pfam17681"
                     /db_xref="CDD:465456"
     Region          350..616
                     /region_name="GCP_C_terminal"
                     /note="Gamma tubulin complex component C-terminal;
                     pfam04130"
                     /db_xref="CDD:461187"
     CDS             1..628
                     /gene="TUBGCP4"
                     /gene_synonym="76P; GCP-4; GCP4; Grip76; MCCRP3"
                     /coded_by="XM_011521454.4:255..2141"
                     /db_xref="GeneID:27229"
                     /db_xref="HGNC:HGNC:16691"
                     /db_xref="MIM:609610"
ORIGIN      
        1 mihelllals gypgsiftwn krsglqvsqd fpflhpsets vlnrlcrlgt dyirftefie
       61 qytghvqqqd hhpsqqgqgg lhgiylrafc tgldsvlqpy rqalldleqe flgdphlsis
      121 hvnyfldqfq llfpsvmvvv eqiksqkihg cqiletvykh scgglppvrs alekilavch
      181 gvmykqlsaw mlhgllldqh eeffikqgps sgnvsaqpee deedlgiggl tgkqlrelqd
      241 lrlieeenml apslkqfslr veilpsyipv rvaekilfvg esvqmfenqn vnltrkgsil
      301 knqedtfaae lhrlkqqplf slvdfeqvvd rirstvaehl wklmveesdl lgqlkiikdf
      361 yllgrgelfq afidtaqhml ktpptavteh dvnvafqqsa hkvlldddnl lpllhltiey
      421 hgkehkadat qaregpsret spreapasgw aalglsykvq wplhilftpa vlekynvvfk
      481 yllsvrrvqa elqhcwalqm qrkhlksnqt daikwrlrnh maflvdnlqy ylqvdvlesq
      541 fsqllhqins trdfesirla hdhflsnlla qsfillkpgf srqssllfki lssvrnhqin
      601 sdlaqlllrl dynkyytqag gtlgsfgm
//
LOCUS       XP_016877567             627 aa            linear   PRI 05-AUG-2025
DEFINITION  gamma-tubulin complex component 4 isoform X4 [Homo sapiens].
ACCESSION   XP_016877567
VERSION     XP_016877567.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022078.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..627
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..627
                     /product="gamma-tubulin complex component 4 isoform X4"
                     /calculated_mol_wt=71621
     Region          2..347
                     /region_name="GCP_N_terminal"
                     /note="Gamma tubulin complex component N-terminal;
                     pfam17681"
                     /db_xref="CDD:465456"
     Region          350..615
                     /region_name="GCP_C_terminal"
                     /note="Gamma tubulin complex component C-terminal;
                     pfam04130"
                     /db_xref="CDD:461187"
     CDS             1..627
                     /gene="TUBGCP4"
                     /gene_synonym="76P; GCP-4; GCP4; Grip76; MCCRP3"
                     /coded_by="XM_017022078.3:255..2138"
                     /db_xref="GeneID:27229"
                     /db_xref="HGNC:HGNC:16691"
                     /db_xref="MIM:609610"
ORIGIN      
        1 mihelllals gypgsiftwn krsglqvsqd fpflhpsets vlnrlcrlgt dyirftefie
       61 qytghvqqqd hhpsqqgqgg lhgiylrafc tgldsvlqpy rqalldleqe flgdphlsis
      121 hvnyfldqfq llfpsvmvvv eqiksqkihg cqiletvykh scgglppvrs alekilavch
      181 gvmykqlsaw mlhgllldqh eeffikqgps sgnvsaqpee deedlgiggl tgkqlrelqd
      241 lrlieeenml apslkqfslr veilpsyipv rvaekilfvg esvqmfenqn vnltrkgsil
      301 knqedtfaae lhrlkqqplf slvdfeqvvd rirstvaehl wklmveesdl lgqlkiikdf
      361 yllgrgelfq afidtaqhml ktpptavteh dvnvafqqsa hkvlldddnl lpllhltiey
      421 hgkehkdatq aregpsrets preapasgwa alglsykvqw plhilftpav lekynvvfky
      481 llsvrrvqae lqhcwalqmq rkhlksnqtd aikwrlrnhm aflvdnlqyy lqvdvlesqf
      541 sqllhqinst rdfesirlah dhflsnllaq sfillkpgfs rqssllfkil ssvrnhqins
      601 dlaqlllrld ynkyytqagg tlgsfgm
//
LOCUS       XP_011519757             531 aa            linear   PRI 05-AUG-2025
DEFINITION  gamma-tubulin complex component 4 isoform X5 [Homo sapiens].
ACCESSION   XP_011519757
VERSION     XP_011519757.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521455.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..531
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..531
                     /product="gamma-tubulin complex component 4 isoform X5"
                     /calculated_mol_wt=60370
     Region          <2..211
                     /region_name="GCP_N_terminal"
                     /note="Gamma tubulin complex component N-terminal;
                     pfam17681"
                     /db_xref="CDD:465456"
     Region          214..519
                     /region_name="GCP_C_terminal"
                     /note="Gamma tubulin complex component C-terminal;
                     pfam04130"
                     /db_xref="CDD:461187"
     CDS             1..531
                     /gene="TUBGCP4"
                     /gene_synonym="76P; GCP-4; GCP4; Grip76; MCCRP3"
                     /coded_by="XM_011521455.3:322..1917"
                     /db_xref="GeneID:27229"
                     /db_xref="HGNC:HGNC:16691"
                     /db_xref="MIM:609610"
ORIGIN      
        1 mvvveqiksq kihgcqilet vykhscgglp pvrsalekil avchgvmykq lsawmlhgll
       61 ldqheeffik qgpssgnvsa qpeedeedlg iggltgkqlr elqdlrliee enmlapslkq
      121 fslrveilps yipvrvaeki lfvgesvqmf enqnvnltrk gsilknqedt faaelhrlkq
      181 qplfslvdfe qvvdrirstv aehlwklmve esdllgqlki ikdfyllgrg elfqafidta
      241 qhmlktppta vtehdvnvaf qqsahkvlld ddnllpllhl tieyhgkehk adatqaregp
      301 sretspreap asgwaalgls ykvqwplhil ftpavlekyn vvfkyllsvr rvqaelqhcw
      361 alqmqrkhlk snqtdaikwr lrnhmaflvd nlqyylqvdv lesqfsqllh qinstrdfes
      421 irlahdhfls nllaqsfill kpvfhclnei ldlchsfcsl vsqnlgplde rgaaqlsilv
      481 kgfsrqssll fkilssvrnh qinsdlaqll lrldynkyyt qaggtlgsfg m
//
LOCUS       XP_047288348             478 aa            linear   PRI 05-AUG-2025
DEFINITION  gamma-tubulin complex component 4 isoform X6 [Homo sapiens].
ACCESSION   XP_047288348
VERSION     XP_047288348.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432392.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..478
                     /product="gamma-tubulin complex component 4 isoform X6"
                     /calculated_mol_wt=54152
     Region          2..347
                     /region_name="GCP_N_terminal"
                     /note="Gamma tubulin complex component N-terminal;
                     pfam17681"
                     /db_xref="CDD:465456"
     Region          350..>474
                     /region_name="GCP_C_terminal"
                     /note="Gamma tubulin complex component C-terminal;
                     pfam04130"
                     /db_xref="CDD:461187"
     CDS             1..478
                     /gene="TUBGCP4"
                     /gene_synonym="76P; GCP-4; GCP4; Grip76; MCCRP3"
                     /coded_by="XM_047432392.1:255..1691"
                     /db_xref="GeneID:27229"
                     /db_xref="HGNC:HGNC:16691"
                     /db_xref="MIM:609610"
ORIGIN      
        1 mihelllals gypgsiftwn krsglqvsqd fpflhpsets vlnrlcrlgt dyirftefie
       61 qytghvqqqd hhpsqqgqgg lhgiylrafc tgldsvlqpy rqalldleqe flgdphlsis
      121 hvnyfldqfq llfpsvmvvv eqiksqkihg cqiletvykh scgglppvrs alekilavch
      181 gvmykqlsaw mlhgllldqh eeffikqgps sgnvsaqpee deedlgiggl tgkqlrelqd
      241 lrlieeenml apslkqfslr veilpsyipv rvaekilfvg esvqmfenqn vnltrkgsil
      301 knqedtfaae lhrlkqqplf slvdfeqvvd rirstvaehl wklmveesdl lgqlkiikdf
      361 yllgrgelfq afidtaqhml ktpptavteh dvnvafqqsa hkvlldddnl lpllhltiey
      421 hgkehkadat qaregpsret spreapasgw aalglsykvq wplhilftpa vleknrqf
//
LOCUS       XP_047288349             477 aa            linear   PRI 05-AUG-2025
DEFINITION  gamma-tubulin complex component 4 isoform X7 [Homo sapiens].
ACCESSION   XP_047288349
VERSION     XP_047288349.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432393.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..477
                     /product="gamma-tubulin complex component 4 isoform X7"
                     /calculated_mol_wt=54081
     Region          2..347
                     /region_name="GCP_N_terminal"
                     /note="Gamma tubulin complex component N-terminal;
                     pfam17681"
                     /db_xref="CDD:465456"
     Region          350..>473
                     /region_name="GCP_C_terminal"
                     /note="Gamma tubulin complex component C-terminal;
                     pfam04130"
                     /db_xref="CDD:461187"
     CDS             1..477
                     /gene="TUBGCP4"
                     /gene_synonym="76P; GCP-4; GCP4; Grip76; MCCRP3"
                     /coded_by="XM_047432393.1:255..1688"
                     /db_xref="GeneID:27229"
                     /db_xref="HGNC:HGNC:16691"
                     /db_xref="MIM:609610"
ORIGIN      
        1 mihelllals gypgsiftwn krsglqvsqd fpflhpsets vlnrlcrlgt dyirftefie
       61 qytghvqqqd hhpsqqgqgg lhgiylrafc tgldsvlqpy rqalldleqe flgdphlsis
      121 hvnyfldqfq llfpsvmvvv eqiksqkihg cqiletvykh scgglppvrs alekilavch
      181 gvmykqlsaw mlhgllldqh eeffikqgps sgnvsaqpee deedlgiggl tgkqlrelqd
      241 lrlieeenml apslkqfslr veilpsyipv rvaekilfvg esvqmfenqn vnltrkgsil
      301 knqedtfaae lhrlkqqplf slvdfeqvvd rirstvaehl wklmveesdl lgqlkiikdf
      361 yllgrgelfq afidtaqhml ktpptavteh dvnvafqqsa hkvlldddnl lpllhltiey
      421 hgkehkdatq aregpsrets preapasgwa alglsykvqw plhilftpav leknrqf
//
LOCUS       XP_047288350             531 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium/potassium/calcium exchanger 5 isoform X1 [Homo sapiens].
ACCESSION   XP_047288350
VERSION     XP_047288350.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432394.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..531
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..531
                     /product="sodium/potassium/calcium exchanger 5 isoform X1"
                     /calculated_mol_wt=58340
     Region          <20..>255
                     /region_name="2A1904"
                     /note="K+-dependent Na+/Ca+ exchanger; TIGR00927"
                     /db_xref="CDD:273344"
     Region          <321..521
                     /region_name="2A1904"
                     /note="K+-dependent Na+/Ca+ exchanger; TIGR00927"
                     /db_xref="CDD:273344"
     CDS             1..531
                     /gene="SLC24A5"
                     /gene_synonym="JSX; NCKX5; OCA6; SHEP4"
                     /coded_by="XM_047432394.1:56..1651"
                     /db_xref="GeneID:283652"
                     /db_xref="HGNC:HGNC:20611"
                     /db_xref="MIM:609802"
ORIGIN      
        1 mqtkggqtwa rralllgilw atahlplsgt slpqrlprat gnstqcvisp ssefpegfft
       61 rqerrdggii iyfliivymf maisivcdey flpsleiise slglsqdvag ttfmaagssa
      121 pelvtaflgk ycslyflltq cdfyflqvnt nlagtilhig vfitkgdigi stilgsaiyn
      181 llgicaacgl lsntvstlsc wplfrdcaay tisaaavlgi iydnqvywye galllliygl
      241 yvlvlcfdik inqyiikkcs pccaclakam erseqqplmg wedegqpfir rqsrtdsgif
      301 yedsgysqls islhglsqvs edppsvfnmp eadlkrifwv lslpiitllf lttpdcrkkf
      361 wknyfvitff msaiwisaft yilvwmvtit getleipdtv mgltllaagt sipdtiasvl
      421 varkgkgdma msnivgsnvf dmlclgipwf iktafingsa paevnsrglt yitislnisi
      481 iflflavhfn gwkldrklgi vcllsylgla tlsvlyelgi ignnkirgcg g
//
LOCUS       XP_024305669             387 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium/potassium/calcium exchanger 5 isoform X2 [Homo sapiens].
ACCESSION   XP_024305669
VERSION     XP_024305669.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449901.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XP_024305669.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..387
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..387
                     /product="sodium/potassium/calcium exchanger 5 isoform X2"
                     /calculated_mol_wt=42273
     Region          <1..>111
                     /region_name="2A1904"
                     /note="K+-dependent Na+/Ca+ exchanger; TIGR00927"
                     /db_xref="CDD:273344"
     Region          <177..377
                     /region_name="2A1904"
                     /note="K+-dependent Na+/Ca+ exchanger; TIGR00927"
                     /db_xref="CDD:273344"
     CDS             1..387
                     /gene="SLC24A5"
                     /gene_synonym="JSX; NCKX5; OCA6; SHEP4"
                     /coded_by="XM_024449901.2:230..1393"
                     /db_xref="GeneID:283652"
                     /db_xref="HGNC:HGNC:20611"
                     /db_xref="MIM:609802"
ORIGIN      
        1 maagssapel vtaflgvfit kgdigistil gsaiynllgi caacgllsnt vstlscwplf
       61 rdcaaytisa aavlgiiydn qvywyegall lliyglyvlv lcfdikinqy iikkcspcca
      121 clakamerse qqplmgwede gqpfirrqsr tdsgifyeds gysqlsislh glsqvsedpp
      181 svfnmpeadl krifwvlslp iitllflttp dcrkkfwkny fvitffmsai wisaftyilv
      241 wmvtitgetl eipdtvmglt llaagtsipd tiasvlvark gkgdmamsni vgsnvfdmlc
      301 lgipwfikta fingsapaev nsrgltyiti slnisiiflf lavhfngwkl drklgivcll
      361 sylglatlsv lyelgiignn kirgcgg
//
LOCUS       XP_047288351             387 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium/potassium/calcium exchanger 5 isoform X2 [Homo sapiens].
ACCESSION   XP_047288351
VERSION     XP_047288351.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432395.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..387
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..387
                     /product="sodium/potassium/calcium exchanger 5 isoform X2"
                     /calculated_mol_wt=42273
     Region          <1..>111
                     /region_name="2A1904"
                     /note="K+-dependent Na+/Ca+ exchanger; TIGR00927"
                     /db_xref="CDD:273344"
     Region          <177..377
                     /region_name="2A1904"
                     /note="K+-dependent Na+/Ca+ exchanger; TIGR00927"
                     /db_xref="CDD:273344"
     CDS             1..387
                     /gene="SLC24A5"
                     /gene_synonym="JSX; NCKX5; OCA6; SHEP4"
                     /coded_by="XM_047432395.1:314..1477"
                     /db_xref="GeneID:283652"
                     /db_xref="HGNC:HGNC:20611"
                     /db_xref="MIM:609802"
ORIGIN      
        1 maagssapel vtaflgvfit kgdigistil gsaiynllgi caacgllsnt vstlscwplf
       61 rdcaaytisa aavlgiiydn qvywyegall lliyglyvlv lcfdikinqy iikkcspcca
      121 clakamerse qqplmgwede gqpfirrqsr tdsgifyeds gysqlsislh glsqvsedpp
      181 svfnmpeadl krifwvlslp iitllflttp dcrkkfwkny fvitffmsai wisaftyilv
      241 wmvtitgetl eipdtvmglt llaagtsipd tiasvlvark gkgdmamsni vgsnvfdmlc
      301 lgipwfikta fingsapaev nsrgltyiti slnisiiflf lavhfngwkl drklgivcll
      361 sylglatlsv lyelgiignn kirgcgg
//
LOCUS       XP_016877570            1072 aa            linear   PRI 05-AUG-2025
DEFINITION  protogenin isoform X1 [Homo sapiens].
ACCESSION   XP_016877570
VERSION     XP_016877570.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022081.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1072
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1072
                     /product="protogenin isoform X1"
                     /calculated_mol_wt=118312
     Region          <1..52
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          13..17
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          32..37
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          46..49
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          63..145
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          74..78
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          87..91
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          110..114
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          124..129
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          157..229
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     Region          249..334
                     /region_name="I-set"
                     /note="Immunoglobulin I-set domain; pfam07679"
                     /db_xref="CDD:400151"
     Region          267..270
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          279..283
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          300..304
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          314..319
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          327..330
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          341..434
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(341,407,422)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Site            order(423..424,426..427)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          439..532
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(439,505,520)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Site            order(521..522,524..525)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Site            order(541,604,619)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          546..621
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Region          <650..>858
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     Region          743..833
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(825..826,828..829)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     CDS             1..1072
                     /gene="PRTG"
                     /gene_synonym="IGDCC5"
                     /coded_by="XM_017022081.3:283..3501"
                     /db_xref="GeneID:283659"
                     /db_xref="HGNC:HGNC:26373"
                     /db_xref="MIM:613261"
ORIGIN      
        1 msenkrievl sngslyisev egrrgeqsde gfyqclamnk ygailsqkah lalstisafe
       61 vqpistevhe ggvarfacki sshppavitw efnrttlpmt mdritalptg vlqiydvsqr
      121 dsgnyrciaa tvahrrksme asltvipake sksfhtptii agpqnittsl hqtvvlecma
      181 tgnpkpiisw srldhksidv fntrvlgngn lmisdvrlqh agvyvcratt pgtrnftvam
      241 atltvlapps fvewpesltr pragtarfvc qaegipspkm swlkngrkih sngrikmyns
      301 klvinqiipe ddaiyqcmae nsqgsilsra rltvvmsedr psapynvhae tmsssailla
      361 werplynsdk viaysvhymk aeglnneeyq vvigndtthy iiddlepasn ytfyivaymp
      421 mgasqmsdhv tqntledvpl rppeisltsr sptdiliswl pipakyrrgq vvlyrlsfrl
      481 stensiqvle lpgttheyll eglkpdsvyl vritaatrvg lgessvwtsh rtpkatsvka
      541 pkspelhlep lncttisvrw qqdvedtaai qgyklyykee gqqengpifl dtkdllytls
      601 gldprrkyhv rllaynnidd gyqadqtvst pgcvsvrdrm vpppppphhl yakantsssi
      661 flhwrrpaft aaqiinytir cnpvglqnas lvlylqtset hmlvqglepn tkyefavrlh
      721 vdqlsspwsp vvyhstlpea pagppvgvkv tlieddtalv swkppdgpet vvtrytilya
      781 srkawiagew qvlhregait mallenlvag nvyivkisas nevgegpfsn svelavlpke
      841 tsesnqrpkr ldsadakvys gyyhldqksm tgiavgvgia ltcilicvli liyrskarks
      901 sasktaqngt qqlprtsasl asgnevgknl egavgneesl mpmimpnsfi dakggtdlii
      961 nsygpiiknn skkkwfffqd skkiqveqpq rrftpavcfy qpgttvlisd edspsspgqt
     1021 tsfsrpfgva adtehsanse gshetgdsgr fshesndeih lssvisttpp nl
//
LOCUS       XP_016877571             927 aa            linear   PRI 05-AUG-2025
DEFINITION  protogenin isoform X2 [Homo sapiens].
ACCESSION   XP_016877571
VERSION     XP_016877571.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022082.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..927
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..927
                     /product="protogenin isoform X2"
                     /calculated_mol_wt=102836
     Region          38..130
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          56..60
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          69..73
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          91..95
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          110..115
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          124..127
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          141..223
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          152..156
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          165..169
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          188..192
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          202..207
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          235..307
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     Region          327..412
                     /region_name="I-set"
                     /note="Immunoglobulin I-set domain; pfam07679"
                     /db_xref="CDD:400151"
     Region          345..348
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:143205"
     Region          357..361
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:143205"
     Region          378..382
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:143205"
     Region          392..397
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:143205"
     Region          405..408
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:143205"
     Region          419..512
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(419,485,500)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          <481..>710
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     Site            order(501..502,504..505)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          726..814
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(803..804,806..807)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          821..>890
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     CDS             1..927
                     /gene="PRTG"
                     /gene_synonym="IGDCC5"
                     /coded_by="XM_017022082.3:222..3005"
                     /db_xref="GeneID:283659"
                     /db_xref="HGNC:HGNC:26373"
                     /db_xref="MIM:613261"
ORIGIN      
        1 mapplrplar lrppgmllra lllllllspl pgvwcfsels fvkepqdvtv trkdpvvldc
       61 qahgevpikv twlkngakms enkrievlsn gslyiseveg rrgeqsdegf yqclamnkyg
      121 ailsqkahla lstisafevq pistevhegg varfackiss hppavitwef nrttlpmtmd
      181 ritalptgvl qiydvsqrds gnyrciaatv ahrrksmeas ltvipakesk sfhtptiiag
      241 pqnittslhq tvvlecmatg npkpiiswsr ldhksidvfn trvlgngnlm isdvrlqhag
      301 vyvcrattpg trnftvamat ltvlappsfv ewpesltrpr agtarfvcqa egipspkmsw
      361 lkngrkihsn grikmynskl vinqiipedd aiyqcmaens qgsilsrarl tvvmsedrps
      421 apynvhaetm sssaillawe rplynsdkvi aysvhymkae glnneeyqvv igndtthyii
      481 ddlepasnyt fyivaympmg asqmsdhvtq ntledvplrp peisltsrsp tdiliswlpi
      541 pakyrrgqvv lyrlsfrlst ensiqvlelp gttheylleg lkpdsvylvr itaatrvglg
      601 essvwtshrt pkatsvkapk spelhlepln cttisvrwqq dvedtaaiqg yklyykeegq
      661 qengpifldt kdllytlsgl dprrkyhvrl laynniddgy qadqtvstpg cvsvrdrmvp
      721 ppppphhlya kantsssifl hwrrpaftaa qiinytircn pvglqnaslv lylqtsethm
      781 lvqglepntk yefavrlhvd qlsspwspvv yhstlpeapa gppvgvkvtl ieddtalvsw
      841 kppdgpetvv trytilyasr kawiagewqv lhrevvysss shslqaklkp enmktscvla
      901 pgiaagglaa shrvtcrdgl rlmtsal
//
LOCUS       XP_011519761             701 aa            linear   PRI 05-AUG-2025
DEFINITION  protogenin isoform X3 [Homo sapiens].
ACCESSION   XP_011519761
VERSION     XP_011519761.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521459.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..701
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..701
                     /product="protogenin isoform X3"
                     /calculated_mol_wt=77860
     Region          38..130
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          56..60
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          69..73
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          91..95
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          110..115
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          124..127
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          141..223
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          152..156
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          165..169
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          188..192
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          202..207
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          235..307
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     Region          327..412
                     /region_name="I-set"
                     /note="Immunoglobulin I-set domain; pfam07679"
                     /db_xref="CDD:400151"
     Region          345..348
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          357..361
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          378..382
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          392..397
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          405..408
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          419..512
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(419,485,500)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Site            order(501..502,504..505)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          517..610
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(517,583,598)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Site            order(599..600,602..603)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          619..>681
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     CDS             1..701
                     /gene="PRTG"
                     /gene_synonym="IGDCC5"
                     /coded_by="XM_011521459.3:222..2327"
                     /db_xref="GeneID:283659"
                     /db_xref="HGNC:HGNC:26373"
                     /db_xref="MIM:613261"
ORIGIN      
        1 mapplrplar lrppgmllra lllllllspl pgvwcfsels fvkepqdvtv trkdpvvldc
       61 qahgevpikv twlkngakms enkrievlsn gslyiseveg rrgeqsdegf yqclamnkyg
      121 ailsqkahla lstisafevq pistevhegg varfackiss hppavitwef nrttlpmtmd
      181 ritalptgvl qiydvsqrds gnyrciaatv ahrrksmeas ltvipakesk sfhtptiiag
      241 pqnittslhq tvvlecmatg npkpiiswsr ldhksidvfn trvlgngnlm isdvrlqhag
      301 vyvcrattpg trnftvamat ltvlappsfv ewpesltrpr agtarfvcqa egipspkmsw
      361 lkngrkihsn grikmynskl vinqiipedd aiyqcmaens qgsilsrarl tvvmsedrps
      421 apynvhaetm sssaillawe rplynsdkvi aysvhymkae glnneeyqvv igndtthyii
      481 ddlepasnyt fyivaympmg asqmsdhvtq ntledvplrp peisltsrsp tdiliswlpi
      541 pakyrrgqvv lyrlsfrlst ensiqvlelp gttheylleg lkpdsvylvr itaatrvglg
      601 essvwtshrt pkatsvkapk spelhlepln cttisvrwqq dvedtaaiqg yklyykeegq
      661 qengpifldt kdllytlsgl vflskmfspn limkpsdksg l
//
LOCUS       XP_011519762             683 aa            linear   PRI 05-AUG-2025
DEFINITION  protogenin isoform X4 [Homo sapiens].
ACCESSION   XP_011519762
VERSION     XP_011519762.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521460.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..683
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..683
                     /product="protogenin isoform X4"
                     /calculated_mol_wt=75879
     Region          38..130
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          56..60
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          69..73
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          91..95
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          110..115
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          124..127
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          141..223
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          152..156
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          165..169
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          188..192
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          202..207
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          235..307
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     Region          327..412
                     /region_name="I-set"
                     /note="Immunoglobulin I-set domain; pfam07679"
                     /db_xref="CDD:400151"
     Region          345..348
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          357..361
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          378..382
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          392..397
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          405..408
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          419..512
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(419,485,500)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Site            order(501..502,504..505)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          517..610
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(517,583,598)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Site            order(599..600,602..603)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          619..>680
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     CDS             1..683
                     /gene="PRTG"
                     /gene_synonym="IGDCC5"
                     /coded_by="XM_011521460.3:222..2273"
                     /db_xref="GeneID:283659"
                     /db_xref="HGNC:HGNC:26373"
                     /db_xref="MIM:613261"
ORIGIN      
        1 mapplrplar lrppgmllra lllllllspl pgvwcfsels fvkepqdvtv trkdpvvldc
       61 qahgevpikv twlkngakms enkrievlsn gslyiseveg rrgeqsdegf yqclamnkyg
      121 ailsqkahla lstisafevq pistevhegg varfackiss hppavitwef nrttlpmtmd
      181 ritalptgvl qiydvsqrds gnyrciaatv ahrrksmeas ltvipakesk sfhtptiiag
      241 pqnittslhq tvvlecmatg npkpiiswsr ldhksidvfn trvlgngnlm isdvrlqhag
      301 vyvcrattpg trnftvamat ltvlappsfv ewpesltrpr agtarfvcqa egipspkmsw
      361 lkngrkihsn grikmynskl vinqiipedd aiyqcmaens qgsilsrarl tvvmsedrps
      421 apynvhaetm sssaillawe rplynsdkvi aysvhymkae glnneeyqvv igndtthyii
      481 ddlepasnyt fyivaympmg asqmsdhvtq ntledvplrp peisltsrsp tdiliswlpi
      541 pakyrrgqvv lyrlsfrlst ensiqvlelp gttheylleg lkpdsvylvr itaatrvglg
      601 essvwtshrt pkatsvkapk spelhlepln cttisvrwqq dvedtaaiqg yklyykeegq
      661 qengpifldt kdllytlsgl ari
//
LOCUS       XP_047288352             856 aa            linear   PRI 05-AUG-2025
DEFINITION  golgin subfamily A member 6-like protein 2 isoform X1 [Homo
            sapiens].
ACCESSION   XP_047288352
VERSION     XP_047288352.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432396.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 26% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..856
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..856
                     /product="golgin subfamily A member 6-like protein 2
                     isoform X1"
                     /calculated_mol_wt=94530
     Region          <140..391
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          <244..>737
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     CDS             1..856
                     /gene="GOLGA6L2"
                     /gene_synonym="CT105"
                     /coded_by="XM_047432396.1:63..2633"
                     /db_xref="GeneID:283685"
                     /db_xref="HGNC:HGNC:26695"
ORIGIN      
        1 mwpqphlpph pmmsektrqn klaeakkkek kashqhqeal rreieaqdht iriltcqkte
       61 letalyysqd aarkfedgnl gtpssfnlal sqafrgsplg cvstslipge skdlagrlhh
      121 swhfagelqr alsavstwhk kadryieelt kerdalslel yrntitneel kkknaelqek
      181 lrlaesekse iqlnvkelkr klerakfllp qvqtntlqee mwrqeeelre qekkirkqee
      241 kmwrqeerlr eqegkmreqe ekmrrqekrl reqekelreq ekelreqkkl reqeeqmqeq
      301 eekmweqeek mreqeekmwr qeerlweqek qmreqeqkmr dqeermweqd erlrekeerm
      361 reqekmweqv ekmreekkmq eqekktrdqe ekmqeeerir erekkmreee etmreqeekm
      421 qkqeenmweq eekewqqqrl peqkeklweq ekmqeqeeki weqeekirdq eemwgqekkm
      481 wrqekmreqe dvetggeaag ageadvgagg edagsgaedv gpggedvgag reaageggen
      541 agaeedvaag gedaggeeda gageedmgpg gedarggeda gageedaggg gddagagged
      601 agagredaga ggedvgagre dagaggedvg aggedvgagr rrcgssrgcr nrrrscgntr
      661 rcrsrrsgae dvgpegedvg agreaagegg enagaedvaa ggedageeed aggedagaar
      721 edagaggddv gagredagag gedvgagged agaggedaga ggedagpgge dagaggedag
      781 pggedagagg edagpggedv gpggedvgag gedvgaggda reggedtrse redageaara
      841 rgavlralpp slqssl
//
LOCUS       XP_047288353             675 aa            linear   PRI 05-AUG-2025
DEFINITION  golgin subfamily A member 6-like protein 2 isoform X2 [Homo
            sapiens].
ACCESSION   XP_047288353
VERSION     XP_047288353.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432397.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..675
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..675
                     /product="golgin subfamily A member 6-like protein 2
                     isoform X2"
                     /calculated_mol_wt=82186
     Region          <221..584
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          627..669
                     /region_name="GM130_C"
                     /note="GM130 C-terminal binding motif; pfam19046"
                     /db_xref="CDD:465957"
     CDS             1..675
                     /gene="GOLGA6L2"
                     /gene_synonym="CT105"
                     /coded_by="XM_047432397.1:63..2090"
                     /db_xref="GeneID:283685"
                     /db_xref="HGNC:HGNC:26695"
ORIGIN      
        1 mwpqphlpph pmmsektrqn klaeakkkft dyrqwniagv gtratdtkkk kinngtnpet
       61 ttsegchspe dtqqnraqlk eekkashqhq ealrreieaq dhtiriltcq kteletalyy
      121 sqdaarkfed gnlgtpssfn lalsqafrgs plgcvstsli pgeskdlagr lhhswhfage
      181 lqralsavst whkkadryie eltkerdals lelyrntitn eelkkknael qeklrlaese
      241 kseiqlnvke lkrklerakf llpqvqtntl qeemwrqeee lreqekkirk qeekmwrqee
      301 rlreqegkmr eqeekmrrqe krlreqekel reqekelreq kklreqeeqm qeqeekmweq
      361 eekmreqeek mwrqeerlwe qekqmreqeq kmlrekeerm reqekmweqe ekmqeqeekm
      421 reqeekmweq eekmqeqeek mweqeekmwe qeeedmrekk ktqeekmqeq qekmqeqeem
      481 mweqeekmqe qeekmweqee kmreqeekmr eqeekmqgqe ekmreqeekm qgqeekmreq
      541 eekmrgqeek mwgqeekmwg qeekmwgqee mrekeerird qkekmqerlp eheercsepc
      601 lppskvlcnm shtgsvepag geagegspqd nptaqeimql fcgmknaqqc pglgstscip
      661 ffyrgdkrkm kiini
//
LOCUS       XP_024305670             453 aa            linear   PRI 05-AUG-2025
DEFINITION  stabilizer of axonemal microtubules 2 isoform X1 [Homo sapiens].
ACCESSION   XP_024305670
VERSION     XP_024305670.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449902.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..453
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..453
                     /product="stabilizer of axonemal microtubules 2 isoform
                     X1"
                     /calculated_mol_wt=52347
     CDS             1..453
                     /gene="SAXO2"
                     /gene_synonym="FAM154B"
                     /coded_by="XM_024449902.2:344..1705"
                     /db_xref="GeneID:283726"
                     /db_xref="HGNC:HGNC:33727"
ORIGIN      
        1 mqskmppgpg diivhvepqg fmkilgcfal qlniwknilc mtmffhlrvl kpskkfeham
       61 afqfwispvd lfksdycpye ivkqprhvpe eykpkqgkid lgttykrdln sykvqpvaiv
      121 rplerqvkkg kldtvptykd dyrawdlhks elykpeqtyh pptvkfgnst tfqddfvpqe
      181 ikprqsfkps svvkrstapf ngitshrldy iphqlelkfe rpkevykptd qrfedltthr
      241 cdfqgliget aklcrpvhtr vtqnalfegs tefresfqpw eipppevkkv peyvpptgsm
      301 llnstshldy vpyqanhvvp irpvsqkrsn nfpfqgksim kedfpawesc rqglikkqqq
      361 ipnpsgkfdg lstfrshyvp heliptesck plniafkssv pfddvtmysv eytpkrqeic
      421 pasypsppgy ifdntnsqgh kffrkiipav kaf
//
LOCUS       XP_047288354             453 aa            linear   PRI 05-AUG-2025
DEFINITION  stabilizer of axonemal microtubules 2 isoform X1 [Homo sapiens].
ACCESSION   XP_047288354
VERSION     XP_047288354.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432398.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..453
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..453
                     /product="stabilizer of axonemal microtubules 2 isoform
                     X1"
                     /calculated_mol_wt=52347
     CDS             1..453
                     /gene="SAXO2"
                     /gene_synonym="FAM154B"
                     /coded_by="XM_047432398.1:138..1499"
                     /db_xref="GeneID:283726"
                     /db_xref="HGNC:HGNC:33727"
ORIGIN      
        1 mqskmppgpg diivhvepqg fmkilgcfal qlniwknilc mtmffhlrvl kpskkfeham
       61 afqfwispvd lfksdycpye ivkqprhvpe eykpkqgkid lgttykrdln sykvqpvaiv
      121 rplerqvkkg kldtvptykd dyrawdlhks elykpeqtyh pptvkfgnst tfqddfvpqe
      181 ikprqsfkps svvkrstapf ngitshrldy iphqlelkfe rpkevykptd qrfedltthr
      241 cdfqgliget aklcrpvhtr vtqnalfegs tefresfqpw eipppevkkv peyvpptgsm
      301 llnstshldy vpyqanhvvp irpvsqkrsn nfpfqgksim kedfpawesc rqglikkqqq
      361 ipnpsgkfdg lstfrshyvp heliptesck plniafkssv pfddvtmysv eytpkrqeic
      421 pasypsppgy ifdntnsqgh kffrkiipav kaf
//
LOCUS       XP_047288355             751 aa            linear   PRI 05-AUG-2025
DEFINITION  cytosolic phospholipase A2 delta isoform X1 [Homo sapiens].
ACCESSION   XP_047288355
VERSION     XP_047288355.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432399.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..751
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..751
                     /product="cytosolic phospholipase A2 delta isoform X1"
                     /calculated_mol_wt=84415
     Region          23..141
                     /region_name="C2_cPLA2"
                     /note="C2 domain present in cytosolic PhosphoLipase A2
                     (cPLA2); cd04036"
                     /db_xref="CDD:176001"
     Site            order(41,44,66,94,96)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:176001"
     Region          163..268
                     /region_name="cPLA2_C2"
                     /note="Cytosolic phospholipases A2 C2-domain; pfam18695"
                     /db_xref="CDD:465834"
     Region          269..743
                     /region_name="Patatin_and_cPLA2"
                     /note="Patatins and Phospholipases; cl11396"
                     /db_xref="CDD:416256"
     Site            order(330..331,333,361,647)
                     /site_type="active"
                     /db_xref="CDD:132836"
     Site            359..363
                     /site_type="other"
                     /note="nucleophile elbow"
                     /db_xref="CDD:132836"
     CDS             1..751
                     /gene="PLA2G4D"
                     /gene_synonym="cPLA2delta"
                     /coded_by="XM_047432399.1:104..2359"
                     /db_xref="GeneID:283748"
                     /db_xref="HGNC:HGNC:30038"
                     /db_xref="MIM:612864"
ORIGIN      
        1 meslspggpp ghpyqgeast cwqltvrvle arnlrwadll seadpyvilq lstapgmkfk
       61 tktltdtshp vwneafrfli qsqvknvlel siydedsvte ddicfkvlyd isevlpgkll
      121 rktfsqspqg eeeldveflm eetsdrpenl itnkvivare lscldvhlds tgstavvadq
      181 dklelelvlk gsyedtqtsf lgtasafrfh ymaaletels grlrssrsng wngdnsagyl
      241 tvplrpltig kevtmdvpap napgvrlqlk aegcpeelav hlgfnlcaee qaflsrrkqv
      301 vakalkqalq ldrdlqedev pvvgimatgg garamtslyg hllalqklgl ldcvtyfsgi
      361 sgstwtmahl ygdpewsqrd legpiryare hlaksklevf sperlasyrr elelraeqgh
      421 pttfvdlwal vlesmlhgqv mdqklsgqra alergqnplp lylslnvken nletldfkew
      481 vefspyevgf lkygafvppe lfgseffmgr lmrripepri cfleaiwsni fslnlldawy
      541 dltssgeswk qhikdktrsl ekeplttsgt ssrleaswlq pgtalaqafk gfltgrplhq
      601 rspnflqglq lhqdycshkd fstwadyqld smpsqltpke prlclvdaay fintsspsmf
      661 rpgrrldlil sfdyslsapf ealqqtelyc rarglpfprv epspqdqhqp rechlfsdpa
      721 cpeapillhf plvnasfkdh sapafqflps f
//
LOCUS       XP_024305672             669 aa            linear   PRI 05-AUG-2025
DEFINITION  golgin subfamily A member 8G isoform X1 [Homo sapiens].
ACCESSION   XP_024305672
VERSION     XP_024305672.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449904.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..669
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..669
                     /product="golgin subfamily A member 8G isoform X1"
                     /calculated_mol_wt=75072
     Region          107..>352
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          239..>490
                     /region_name="GOLGA2L5"
                     /note="Putative golgin subfamily A member 2-like protein
                     5; pfam15070"
                     /db_xref="CDD:464485"
     Region          630..669
                     /region_name="GM130_C"
                     /note="GM130 C-terminal binding motif; pfam19046"
                     /db_xref="CDD:465957"
     CDS             1..669
                     /gene="GOLGA8G"
                     /gene_synonym="GOLGA8F"
                     /coded_by="XM_024449904.2:63..2072"
                     /db_xref="GeneID:283768"
                     /db_xref="HGNC:HGNC:25328"
ORIGIN      
        1 mwpqarlpph pamaeetrqs klaaakrklk eywqrnspgv pagakrnrkt ngsihetats
       61 ggchspgdsa tgihgespts satlkdlesp cqelavvpds rsvkvsqlkn tikslkqqnk
      121 qvehqleeek kannekqkae relevqiqrl niqkgklntd lyhtkrslry feeeskdlav
      181 rlqhslqrkg eleralsavt atqkkkaerq fssrskarme wkleqsmreq allkaqltql
      241 keslkevqle rdeyaehlkg erarwqqrmr kmsqevcslk kekkhdkyrv eklerslskl
      301 khqmaeplpp eppavpseve lqhlrkeler vagelqaqve ynqrisllne gqkerlreqe
      361 erlqeqqerl peqeerlqql aepqnsfkel nnenksvlql eqqvkelqek lgkerleaas
      421 qqkqqltaql slmalpgegd ggghldsege eaprpipsip qdlesreamv affksagasa
      481 qekqaqlqeq sgfmdhleek adlselveke elgffqyyre rchqkvyhpi tkpggsakda
      541 apggghhqag pgqggdegea agaagdgvaa ggdykghskf lvtaqnpahe pspgapapqe
      601 lgaahkhgdl cevsltdsve pvqgearegs phdnptaqpi vqdhqehpgl gsnccvpffc
      661 wawlprrrr
//
LOCUS       XP_024305673             668 aa            linear   PRI 05-AUG-2025
DEFINITION  golgin subfamily A member 8G isoform X2 [Homo sapiens].
ACCESSION   XP_024305673
VERSION     XP_024305673.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449905.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..668
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..668
                     /product="golgin subfamily A member 8G isoform X2"
                     /calculated_mol_wt=74944
     Region          107..>351
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          238..>489
                     /region_name="GOLGA2L5"
                     /note="Putative golgin subfamily A member 2-like protein
                     5; pfam15070"
                     /db_xref="CDD:464485"
     Region          629..668
                     /region_name="GM130_C"
                     /note="GM130 C-terminal binding motif; pfam19046"
                     /db_xref="CDD:465957"
     CDS             1..668
                     /gene="GOLGA8G"
                     /gene_synonym="GOLGA8F"
                     /coded_by="XM_024449905.2:63..2069"
                     /db_xref="GeneID:283768"
                     /db_xref="HGNC:HGNC:25328"
ORIGIN      
        1 mwpqarlpph pamaeetrqs klaaakrklk eywqrnspgv pagakrnrkt ngsihetats
       61 ggchspgdsa tgihgespts satlkdlesp cqelavvpds rsvkvsqlkn tikslkqqnk
      121 qvehqleeek kannekqkae relevqiqrl niqkgklntd lyhtkrslry feeeskdlav
      181 rlqhslqrkg eleralsavt atqkkkaerf ssrskarmew kleqsmreqa llkaqltqlk
      241 eslkevqler deyaehlkge rarwqqrmrk msqevcslkk ekkhdkyrve klerslsklk
      301 hqmaeplppe ppavpsevel qhlrkelerv agelqaqvey nqrisllneg qkerlreqee
      361 rlqeqqerlp eqeerlqqla epqnsfkeln nenksvlqle qqvkelqekl gkerleaasq
      421 qkqqltaqls lmalpgegdg gghldsegee aprpipsipq dlesreamva ffksagasaq
      481 ekqaqlqeqs gfmdhleeka dlselvekee lgffqyyrer chqkvyhpit kpggsakdaa
      541 pggghhqagp gqggdegeaa gaagdgvaag gdykghskfl vtaqnpahep spgapapqel
      601 gaahkhgdlc evsltdsvep vqgearegsp hdnptaqpiv qdhqehpglg snccvpffcw
      661 awlprrrr
//
LOCUS       XP_024305674             451 aa            linear   PRI 05-AUG-2025
DEFINITION  golgin subfamily A member 8G isoform X3 [Homo sapiens].
ACCESSION   XP_024305674
VERSION     XP_024305674.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449906.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..451
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..451
                     /product="golgin subfamily A member 8G isoform X3"
                     /calculated_mol_wt=50523
     Region          21..>272
                     /region_name="GOLGA2L5"
                     /note="Putative golgin subfamily A member 2-like protein
                     5; pfam15070"
                     /db_xref="CDD:464485"
     Region          412..451
                     /region_name="GM130_C"
                     /note="GM130 C-terminal binding motif; pfam19046"
                     /db_xref="CDD:465957"
     CDS             1..451
                     /gene="GOLGA8G"
                     /gene_synonym="GOLGA8F"
                     /coded_by="XM_024449906.2:614..1969"
                     /db_xref="GeneID:283768"
                     /db_xref="HGNC:HGNC:25328"
ORIGIN      
        1 mewkleqsmr eqallkaqlt qlkeslkevq lerdeyaehl kgerarwqqr mrkmsqevcs
       61 lkkekkhdky rveklersls klkhqmaepl ppeppavpse velqhlrkel ervagelqaq
      121 veynqrisll negqkerlre qeerlqeqqe rlpeqeerlq qlaepqnsfk elnnenksvl
      181 qleqqvkelq eklgkerlea asqqkqqlta qlslmalpge gdggghldse geeaprpips
      241 ipqdlesrea mvaffksaga saqekqaqlq eqsgfmdhle ekadlselve keelgffqyy
      301 rerchqkvyh pitkpggsak daapggghhq agpgqggdeg eaagaagdgv aaggdykghs
      361 kflvtaqnpa hepspgapap qelgaahkhg dlcevsltds vepvqgeare gsphdnptaq
      421 pivqdhqehp glgsnccvpf fcwawlprrr r
//
LOCUS       XP_047288356             142 aa            linear   PRI 05-AUG-2025
DEFINITION  F-box and leucine-rich protein 22 isoform X1 [Homo sapiens].
ACCESSION   XP_047288356
VERSION     XP_047288356.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432400.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..142
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..142
                     /product="F-box and leucine-rich protein 22 isoform X1"
                     /calculated_mol_wt=16487
     Region          9..51
                     /region_name="F-box_FBXL22"
                     /note="F-box domain found in F-box/LRR-repeat protein 22
                     (FBXL22) and similar proteins; cd22129"
                     /db_xref="CDD:438901"
     Site            order(12,16,19..20,23..24,28,30..31,35..37,39)
                     /site_type="other"
                     /note="putative Skp1 binding site [polypeptide binding]"
                     /db_xref="CDD:438901"
     CDS             1..142
                     /gene="FBXL22"
                     /gene_synonym="Fbl22"
                     /coded_by="XM_047432400.1:7..435"
                     /db_xref="GeneID:283807"
                     /db_xref="HGNC:HGNC:27537"
                     /db_xref="MIM:609088"
ORIGIN      
        1 mwplltmhit qlnrecllhl fsfldkdsrk slartcsqlh dvfedpalws llhfrsltel
       61 qkdnfllgpa lrslsicwhs srvqvcsied wlksafqrsi csrheslvnd fllrvcdrff
      121 igrarwhycg plppclvesp st
//
LOCUS       XP_047288357             222 aa            linear   PRI 05-AUG-2025
DEFINITION  annexin A2 isoform X1 [Homo sapiens].
ACCESSION   XP_047288357
VERSION     XP_047288357.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432401.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..222
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..222
                     /product="annexin A2 isoform X1"
                     /calculated_mol_wt=25741
     Region          1..57
                     /region_name="Annexin"
                     /note="pfam00191"
                     /db_xref="CDD:395139"
     Region          76..142
                     /region_name="Annexin"
                     /note="pfam00191"
                     /db_xref="CDD:395139"
     Region          152..217
                     /region_name="Annexin"
                     /note="pfam00191"
                     /db_xref="CDD:395139"
     CDS             1..222
                     /gene="ANXA2"
                     /gene_synonym="ANX2; ANX2L4; CAL1H; HEL-S-270; LIP2; LPC2;
                     LPC2D; P36; PAP-IV"
                     /coded_by="XM_047432401.1:3893..4561"
                     /db_xref="GeneID:302"
                     /db_xref="HGNC:HGNC:537"
                     /db_xref="MIM:151740"
ORIGIN      
        1 mkglgtdeds lieiicsrtn qelqeinrvy kemyktdlek diisdtsgdf rklmvalakg
       61 rraedgsvid yelidqdard lydagvkrkg tdvpkwisim tersvphlqk vfdryksysp
      121 ydmlesirke vkgdlenafl nlvqciqnkp lyfadrlyds mkgkgtrdkv lirimvsrse
      181 vdmlkirsef krkygkslyy yiqqdtkgdy qkallylcgg dd
//
LOCUS       XP_047288358             222 aa            linear   PRI 05-AUG-2025
DEFINITION  annexin A2 isoform X1 [Homo sapiens].
ACCESSION   XP_047288358
VERSION     XP_047288358.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432402.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..222
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..222
                     /product="annexin A2 isoform X1"
                     /calculated_mol_wt=25741
     Region          1..57
                     /region_name="Annexin"
                     /note="pfam00191"
                     /db_xref="CDD:395139"
     Region          76..142
                     /region_name="Annexin"
                     /note="pfam00191"
                     /db_xref="CDD:395139"
     Region          152..217
                     /region_name="Annexin"
                     /note="pfam00191"
                     /db_xref="CDD:395139"
     CDS             1..222
                     /gene="ANXA2"
                     /gene_synonym="ANX2; ANX2L4; CAL1H; HEL-S-270; LIP2; LPC2;
                     LPC2D; P36; PAP-IV"
                     /coded_by="XM_047432402.1:3764..4432"
                     /db_xref="GeneID:302"
                     /db_xref="HGNC:HGNC:537"
                     /db_xref="MIM:151740"
ORIGIN      
        1 mkglgtdeds lieiicsrtn qelqeinrvy kemyktdlek diisdtsgdf rklmvalakg
       61 rraedgsvid yelidqdard lydagvkrkg tdvpkwisim tersvphlqk vfdryksysp
      121 ydmlesirke vkgdlenafl nlvqciqnkp lyfadrlyds mkgkgtrdkv lirimvsrse
      181 vdmlkirsef krkygkslyy yiqqdtkgdy qkallylcgg dd
//
LOCUS       XP_047288359             222 aa            linear   PRI 05-AUG-2025
DEFINITION  annexin A2 isoform X1 [Homo sapiens].
ACCESSION   XP_047288359
VERSION     XP_047288359.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432403.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..222
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..222
                     /product="annexin A2 isoform X1"
                     /calculated_mol_wt=25741
     Region          1..57
                     /region_name="Annexin"
                     /note="pfam00191"
                     /db_xref="CDD:395139"
     Region          76..142
                     /region_name="Annexin"
                     /note="pfam00191"
                     /db_xref="CDD:395139"
     Region          152..217
                     /region_name="Annexin"
                     /note="pfam00191"
                     /db_xref="CDD:395139"
     CDS             1..222
                     /gene="ANXA2"
                     /gene_synonym="ANX2; ANX2L4; CAL1H; HEL-S-270; LIP2; LPC2;
                     LPC2D; P36; PAP-IV"
                     /coded_by="XM_047432403.1:770..1438"
                     /db_xref="GeneID:302"
                     /db_xref="HGNC:HGNC:537"
                     /db_xref="MIM:151740"
ORIGIN      
        1 mkglgtdeds lieiicsrtn qelqeinrvy kemyktdlek diisdtsgdf rklmvalakg
       61 rraedgsvid yelidqdard lydagvkrkg tdvpkwisim tersvphlqk vfdryksysp
      121 ydmlesirke vkgdlenafl nlvqciqnkp lyfadrlyds mkgkgtrdkv lirimvsrse
      181 vdmlkirsef krkygkslyy yiqqdtkgdy qkallylcgg dd
//
LOCUS       XP_047288360             222 aa            linear   PRI 05-AUG-2025
DEFINITION  annexin A2 isoform X1 [Homo sapiens].
ACCESSION   XP_047288360
VERSION     XP_047288360.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432404.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..222
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..222
                     /product="annexin A2 isoform X1"
                     /calculated_mol_wt=25741
     Region          1..57
                     /region_name="Annexin"
                     /note="pfam00191"
                     /db_xref="CDD:395139"
     Region          76..142
                     /region_name="Annexin"
                     /note="pfam00191"
                     /db_xref="CDD:395139"
     Region          152..217
                     /region_name="Annexin"
                     /note="pfam00191"
                     /db_xref="CDD:395139"
     CDS             1..222
                     /gene="ANXA2"
                     /gene_synonym="ANX2; ANX2L4; CAL1H; HEL-S-270; LIP2; LPC2;
                     LPC2D; P36; PAP-IV"
                     /coded_by="XM_047432404.1:641..1309"
                     /db_xref="GeneID:302"
                     /db_xref="HGNC:HGNC:537"
                     /db_xref="MIM:151740"
ORIGIN      
        1 mkglgtdeds lieiicsrtn qelqeinrvy kemyktdlek diisdtsgdf rklmvalakg
       61 rraedgsvid yelidqdard lydagvkrkg tdvpkwisim tersvphlqk vfdryksysp
      121 ydmlesirke vkgdlenafl nlvqciqnkp lyfadrlyds mkgkgtrdkv lirimvsrse
      181 vdmlkirsef krkygkslyy yiqqdtkgdy qkallylcgg dd
//
LOCUS       XP_047288361             222 aa            linear   PRI 05-AUG-2025
DEFINITION  annexin A2 isoform X1 [Homo sapiens].
ACCESSION   XP_047288361
VERSION     XP_047288361.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432405.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..222
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..222
                     /product="annexin A2 isoform X1"
                     /calculated_mol_wt=25741
     Region          1..57
                     /region_name="Annexin"
                     /note="pfam00191"
                     /db_xref="CDD:395139"
     Region          76..142
                     /region_name="Annexin"
                     /note="pfam00191"
                     /db_xref="CDD:395139"
     Region          152..217
                     /region_name="Annexin"
                     /note="pfam00191"
                     /db_xref="CDD:395139"
     CDS             1..222
                     /gene="ANXA2"
                     /gene_synonym="ANX2; ANX2L4; CAL1H; HEL-S-270; LIP2; LPC2;
                     LPC2D; P36; PAP-IV"
                     /coded_by="XM_047432405.1:5586..6254"
                     /db_xref="GeneID:302"
                     /db_xref="HGNC:HGNC:537"
                     /db_xref="MIM:151740"
ORIGIN      
        1 mkglgtdeds lieiicsrtn qelqeinrvy kemyktdlek diisdtsgdf rklmvalakg
       61 rraedgsvid yelidqdard lydagvkrkg tdvpkwisim tersvphlqk vfdryksysp
      121 ydmlesirke vkgdlenafl nlvqciqnkp lyfadrlyds mkgkgtrdkv lirimvsrse
      181 vdmlkirsef krkygkslyy yiqqdtkgdy qkallylcgg dd
//
LOCUS       XP_047288362             222 aa            linear   PRI 05-AUG-2025
DEFINITION  annexin A2 isoform X1 [Homo sapiens].
ACCESSION   XP_047288362
VERSION     XP_047288362.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432406.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..222
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..222
                     /product="annexin A2 isoform X1"
                     /calculated_mol_wt=25741
     Region          1..57
                     /region_name="Annexin"
                     /note="pfam00191"
                     /db_xref="CDD:395139"
     Region          76..142
                     /region_name="Annexin"
                     /note="pfam00191"
                     /db_xref="CDD:395139"
     Region          152..217
                     /region_name="Annexin"
                     /note="pfam00191"
                     /db_xref="CDD:395139"
     CDS             1..222
                     /gene="ANXA2"
                     /gene_synonym="ANX2; ANX2L4; CAL1H; HEL-S-270; LIP2; LPC2;
                     LPC2D; P36; PAP-IV"
                     /coded_by="XM_047432406.1:548..1216"
                     /db_xref="GeneID:302"
                     /db_xref="HGNC:HGNC:537"
                     /db_xref="MIM:151740"
ORIGIN      
        1 mkglgtdeds lieiicsrtn qelqeinrvy kemyktdlek diisdtsgdf rklmvalakg
       61 rraedgsvid yelidqdard lydagvkrkg tdvpkwisim tersvphlqk vfdryksysp
      121 ydmlesirke vkgdlenafl nlvqciqnkp lyfadrlyds mkgkgtrdkv lirimvsrse
      181 vdmlkirsef krkygkslyy yiqqdtkgdy qkallylcgg dd
//
LOCUS       XP_016877581             222 aa            linear   PRI 05-AUG-2025
DEFINITION  annexin A2 isoform X1 [Homo sapiens].
ACCESSION   XP_016877581
VERSION     XP_016877581.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022092.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..222
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..222
                     /product="annexin A2 isoform X1"
                     /calculated_mol_wt=25741
     Region          1..57
                     /region_name="Annexin"
                     /note="pfam00191"
                     /db_xref="CDD:395139"
     Region          76..142
                     /region_name="Annexin"
                     /note="pfam00191"
                     /db_xref="CDD:395139"
     Region          152..217
                     /region_name="Annexin"
                     /note="pfam00191"
                     /db_xref="CDD:395139"
     CDS             1..222
                     /gene="ANXA2"
                     /gene_synonym="ANX2; ANX2L4; CAL1H; HEL-S-270; LIP2; LPC2;
                     LPC2D; P36; PAP-IV"
                     /coded_by="XM_017022092.2:388..1056"
                     /db_xref="GeneID:302"
                     /db_xref="HGNC:HGNC:537"
                     /db_xref="MIM:151740"
ORIGIN      
        1 mkglgtdeds lieiicsrtn qelqeinrvy kemyktdlek diisdtsgdf rklmvalakg
       61 rraedgsvid yelidqdard lydagvkrkg tdvpkwisim tersvphlqk vfdryksysp
      121 ydmlesirke vkgdlenafl nlvqciqnkp lyfadrlyds mkgkgtrdkv lirimvsrse
      181 vdmlkirsef krkygkslyy yiqqdtkgdy qkallylcgg dd
//
LOCUS       XP_047288363             222 aa            linear   PRI 05-AUG-2025
DEFINITION  annexin A2 isoform X1 [Homo sapiens].
ACCESSION   XP_047288363
VERSION     XP_047288363.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432407.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..222
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..222
                     /product="annexin A2 isoform X1"
                     /calculated_mol_wt=25741
     Region          1..57
                     /region_name="Annexin"
                     /note="pfam00191"
                     /db_xref="CDD:395139"
     Region          76..142
                     /region_name="Annexin"
                     /note="pfam00191"
                     /db_xref="CDD:395139"
     Region          152..217
                     /region_name="Annexin"
                     /note="pfam00191"
                     /db_xref="CDD:395139"
     CDS             1..222
                     /gene="ANXA2"
                     /gene_synonym="ANX2; ANX2L4; CAL1H; HEL-S-270; LIP2; LPC2;
                     LPC2D; P36; PAP-IV"
                     /coded_by="XM_047432407.1:467..1135"
                     /db_xref="GeneID:302"
                     /db_xref="HGNC:HGNC:537"
                     /db_xref="MIM:151740"
ORIGIN      
        1 mkglgtdeds lieiicsrtn qelqeinrvy kemyktdlek diisdtsgdf rklmvalakg
       61 rraedgsvid yelidqdard lydagvkrkg tdvpkwisim tersvphlqk vfdryksysp
      121 ydmlesirke vkgdlenafl nlvqciqnkp lyfadrlyds mkgkgtrdkv lirimvsrse
      181 vdmlkirsef krkygkslyy yiqqdtkgdy qkallylcgg dd
//
LOCUS       XP_016877583             697 aa            linear   PRI 05-AUG-2025
DEFINITION  histidine decarboxylase isoform X1 [Homo sapiens].
ACCESSION   XP_016877583
VERSION     XP_016877583.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022094.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..697
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..697
                     /product="histidine decarboxylase isoform X1"
                     /calculated_mol_wt=77668
     Region          36..449
                     /region_name="Pyridoxal_deC"
                     /note="Pyridoxal-dependent decarboxylase conserved domain;
                     pfam00282"
                     /db_xref="CDD:395219"
     Site            order(150..151,154,244,308,311,337,340)
                     /site_type="other"
                     /note="pyridoxal 5'-phosphate binding site [chemical
                     binding]"
                     /db_xref="CDD:99743"
     Site            340
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:99743"
     CDS             1..697
                     /gene="HDC"
                     /coded_by="XM_017022094.2:104..2197"
                     /db_xref="GeneID:3067"
                     /db_xref="HGNC:HGNC:4855"
                     /db_xref="MIM:142704"
ORIGIN      
        1 mmepeeyrer gremvdyicq ylstvrerrv tpdvqpgylr aqlpesaped pdswdsifgd
       61 ieriimpgvv hwqsphmhay ypaltswpsl lgdmladain clgftwassp actelemnvm
      121 dwlakmlglp ehflhhhpss qgggvlqstv sestlialla arknkilemk tsepdadesc
      181 lnarlvayas dqahssveka glislvkmkf lpvddnfslr gealqkaiee dkqrglvpvf
      241 vcatlgttgv cafdclselg piskahhpcs pplslarcet sfptsylpsg qvmfassgar
      301 eglwlhidaa yagtaflcpe frgflkgiey adsftfnpsk wmmvhfdctg fwvkdkyklq
      361 qtfsvnpiyl rhansgvatd fmhwqiplsr rfrsvklwfv irsfgvknlq ahvrhgtema
      421 kyfeslvrnd psfeipakrh lglvvfrlkg pncltenvlk eiakagrlfl ipatiqdkli
      481 irftvtsqft trddilrdwn lirdaatlil sqhctsqpsp rvgnlisqir garawacgts
      541 lqsvsgagdd pvqarkiikq pqrvgagpmk renglhletl ldpvddcfse eapdatkhkl
      601 ssflfsylsv qtkkktvrsl scnsvpvsaq kplpteasvk nggssrvrif srfpedmmml
      661 kksafkklik fysvpsfpec ssqcglqlpc cplqamv
//
LOCUS       XP_016877584             664 aa            linear   PRI 05-AUG-2025
DEFINITION  histidine decarboxylase isoform X2 [Homo sapiens].
ACCESSION   XP_016877584
VERSION     XP_016877584.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022095.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..664
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..664
                     /product="histidine decarboxylase isoform X2"
                     /calculated_mol_wt=73586
     Region          36..416
                     /region_name="Pyridoxal_deC"
                     /note="Pyridoxal-dependent decarboxylase conserved domain;
                     pfam00282"
                     /db_xref="CDD:395219"
     Site            order(150..151,154,244,308,311,337,340)
                     /site_type="other"
                     /note="pyridoxal 5'-phosphate binding site [chemical
                     binding]"
                     /db_xref="CDD:99743"
     Site            340
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:99743"
     CDS             1..664
                     /gene="HDC"
                     /coded_by="XM_017022095.2:104..2098"
                     /db_xref="GeneID:3067"
                     /db_xref="HGNC:HGNC:4855"
                     /db_xref="MIM:142704"
ORIGIN      
        1 mmepeeyrer gremvdyicq ylstvrerrv tpdvqpgylr aqlpesaped pdswdsifgd
       61 ieriimpgvv hwqsphmhay ypaltswpsl lgdmladain clgftwassp actelemnvm
      121 dwlakmlglp ehflhhhpss qgggvlqstv sestlialla arknkilemk tsepdadesc
      181 lnarlvayas dqahssveka glislvkmkf lpvddnfslr gealqkaiee dkqrglvpvf
      241 vcatlgttgv cafdclselg piskahhpcs pplslarcet sfptsylpsg qvmfassgar
      301 eglwlhidaa yagtaflcpe frgflkgiey adsftfnpsk wmmvhfdctg fwvkdkyklq
      361 qtfsvnpiyl rhansgvatd fmgtemakyf eslvrndpsf eipakrhlgl vvfrlkgpnc
      421 ltenvlkeia kagrlflipa tiqdkliirf tvtsqfttrd dilrdwnlir daatlilsqh
      481 ctsqpsprvg nlisqirgar awacgtslqs vsgagddpvq arkiikqpqr vgagpmkren
      541 glhletlldp vddcfseeap datkhklssf lfsylsvqtk kktvrslscn svpvsaqkpl
      601 pteasvkngg ssrvrifsrf pedmmmlkks afkklikfys vpsfpecssq cglqlpccpl
      661 qamv
//
LOCUS       XP_016877586             618 aa            linear   PRI 05-AUG-2025
DEFINITION  histidine decarboxylase isoform X3 [Homo sapiens].
ACCESSION   XP_016877586
VERSION     XP_016877586.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022097.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..618
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..618
                     /product="histidine decarboxylase isoform X3"
                     /calculated_mol_wt=68917
     Region          36..370
                     /region_name="Pyridoxal_deC"
                     /note="Pyridoxal-dependent decarboxylase conserved domain;
                     pfam00282"
                     /db_xref="CDD:395219"
     Site            order(71..72,75,165,229,232,258,261)
                     /site_type="other"
                     /note="pyridoxal 5'-phosphate binding pocket [chemical
                     binding]"
                     /db_xref="CDD:99743"
     Site            261
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:99743"
     CDS             1..618
                     /gene="HDC"
                     /coded_by="XM_017022097.2:104..1960"
                     /db_xref="GeneID:3067"
                     /db_xref="HGNC:HGNC:4855"
                     /db_xref="MIM:142704"
ORIGIN      
        1 mmepeeyrer gremvdyicq ylstvrerrv tpdvqpgylr aqlpesaped pdswdsifgd
       61 ieriimpgst vsestliall aarknkilem ktsepdades clnarlvaya sdqahssvek
      121 aglislvkmk flpvddnfsl rgealqkaie edkqrglvpv fvcatlgttg vcafdclsel
      181 gpiskahhpc spplslarce tsfptsylps gqvmfassga reglwlhida ayagtaflcp
      241 efrgflkgie yadsftfnps kwmmvhfdct gfwvkdkykl qqtfsvnpiy lrhansgvat
      301 dfmhwqipls rrfrsvklwf virsfgvknl qahvrhgtem akyfeslvrn dpsfeipakr
      361 hlglvvfrlk gpncltenvl keiakagrlf lipatiqdkl iirftvtsqf ttrddilrdw
      421 nlirdaatli lsqhctsqps prvgnlisqi rgarawacgt slqsvsgagd dpvqarkiik
      481 qpqrvgagpm krenglhlet lldpvddcfs eeapdatkhk lssflfsyls vqtkkktvrs
      541 lscnsvpvsa qkplpteasv knggssrvri fsrfpedmmm lkksafkkli kfysvpsfpe
      601 cssqcglqlp ccplqamv
//
LOCUS       XP_016877587             553 aa            linear   PRI 05-AUG-2025
DEFINITION  histidine decarboxylase isoform X4 [Homo sapiens].
ACCESSION   XP_016877587
VERSION     XP_016877587.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022098.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..553
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..553
                     /product="histidine decarboxylase isoform X4"
                     /calculated_mol_wt=61203
     Region          <3..305
                     /region_name="Pyridoxal_deC"
                     /note="Pyridoxal-dependent decarboxylase conserved domain;
                     pfam00282"
                     /db_xref="CDD:395219"
     Site            order(6..7,10,100,164,167,193,196)
                     /site_type="other"
                     /note="pyridoxal 5'-phosphate binding pocket [chemical
                     binding]"
                     /db_xref="CDD:99743"
     Site            196
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:99743"
     CDS             1..553
                     /gene="HDC"
                     /coded_by="XM_017022098.2:141..1802"
                     /db_xref="GeneID:3067"
                     /db_xref="HGNC:HGNC:4855"
                     /db_xref="MIM:142704"
ORIGIN      
        1 msastvsest liallaarkn kilemktsep dadesclnar lvayasdqah ssvekaglis
       61 lvkmkflpvd dnfslrgeal qkaieedkqr glvpvfvcat lgttgvcafd clselgpisk
      121 ahhpcsppls larcetsfpt sylpsgqvmf assgareglw lhidaayagt aflcpefrgf
      181 lkgieyadsf tfnpskwmmv hfdctgfwvk dkyklqqtfs vnpiylrhan sgvatdfmhw
      241 qiplsrrfrs vklwfvirsf gvknlqahvr hgtemakyfe slvrndpsfe ipakrhlglv
      301 vfrlkgpncl tenvlkeiak agrlflipat iqdkliirft vtsqfttrdd ilrdwnlird
      361 aatlilsqhc tsqpsprvgn lisqirgara wacgtslqsv sgagddpvqa rkiikqpqrv
      421 gagpmkreng lhletlldpv ddcfseeapd atkhklssfl fsylsvqtkk ktvrslscns
      481 vpvsaqkplp teasvknggs srvrifsrfp edmmmlkksa fkklikfysv psfpecssqc
      541 glqlpccplq amv
//
LOCUS       XP_016877588             437 aa            linear   PRI 05-AUG-2025
DEFINITION  histidine decarboxylase isoform X5 [Homo sapiens].
ACCESSION   XP_016877588
VERSION     XP_016877588.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022099.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..437
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..437
                     /product="histidine decarboxylase isoform X5"
                     /calculated_mol_wt=48193
     Region          36..382
                     /region_name="Pyridoxal_deC"
                     /note="Pyridoxal-dependent decarboxylase conserved domain;
                     pfam00282"
                     /db_xref="CDD:395219"
     Site            order(150..151,154,244,308,311,337,340)
                     /site_type="other"
                     /note="pyridoxal 5'-phosphate binding pocket [chemical
                     binding]"
                     /db_xref="CDD:99743"
     Site            340
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:99743"
     CDS             1..437
                     /gene="HDC"
                     /coded_by="XM_017022099.2:104..1417"
                     /db_xref="GeneID:3067"
                     /db_xref="HGNC:HGNC:4855"
                     /db_xref="MIM:142704"
ORIGIN      
        1 mmepeeyrer gremvdyicq ylstvrerrv tpdvqpgylr aqlpesaped pdswdsifgd
       61 ieriimpgvv hwqsphmhay ypaltswpsl lgdmladain clgftwassp actelemnvm
      121 dwlakmlglp ehflhhhpss qgggvlqstv sestlialla arknkilemk tsepdadesc
      181 lnarlvayas dqahssveka glislvkmkf lpvddnfslr gealqkaiee dkqrglvpvf
      241 vcatlgttgv cafdclselg piskahhpcs pplslarcet sfptsylpsg qvmfassgar
      301 eglwlhidaa yagtaflcpe frgflkgiey adsftfnpsk wmmvhfdctg fwvkdkyklq
      361 qtfsvnpiyl rhansgvatd fmvlmpsagt kapkllpstt efcleikglv vfcwgnivhq
      421 qrgniptvpg sgnwgeg
//
LOCUS       XP_047288364             453 aa            linear   PRI 05-AUG-2025
DEFINITION  EH domain-containing protein 4 isoform X1 [Homo sapiens].
ACCESSION   XP_047288364
VERSION     XP_047288364.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432408.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..453
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..453
                     /product="EH domain-containing protein 4 isoform X1"
                     /calculated_mol_wt=51121
     Region          1..215
                     /region_name="EHD"
                     /note="Eps15 homology domain (EHD), C-terminal domain;
                     cd09913"
                     /db_xref="CDD:206740"
     Site            9
                     /site_type="other"
                     /note="G2 box"
                     /db_xref="CDD:206740"
     Site            13..15
                     /site_type="other"
                     /note="Switch I region"
                     /db_xref="CDD:206740"
     Site            68..71
                     /site_type="other"
                     /note="G3 box"
                     /db_xref="CDD:206740"
     Site            order(70..71,98..99)
                     /site_type="other"
                     /note="Switch II region"
                     /db_xref="CDD:206740"
     Site            134..137
                     /site_type="other"
                     /note="G4 box"
                     /db_xref="CDD:206740"
     Site            171..173
                     /site_type="other"
                     /note="G5 box"
                     /db_xref="CDD:206740"
     Region          204..309
                     /region_name="DUF5600"
                     /note="Domain of unknown function (DUF5600); pfam18150"
                     /db_xref="CDD:465667"
     Region          353..446
                     /region_name="EH"
                     /note="Eps15 homology domain; smart00027"
                     /db_xref="CDD:197477"
     CDS             1..453
                     /gene="EHD4"
                     /gene_synonym="PAST4"
                     /coded_by="XM_047432408.1:157..1518"
                     /db_xref="GeneID:30844"
                     /db_xref="HGNC:HGNC:3245"
                     /db_xref="MIM:605892"
ORIGIN      
        1 mrigpepttd sfiavmyget egstpgnalv vdpkkpfrkl srfgnaflnr fmcsqlpnqv
       61 lksisvidsp gilsgekqri srgydfcqvl qwfaervdri illfdahkld isdefseaik
      121 afrgqddkir vvlnkadqvd tqqlmrvyga lmwslgkvin tpevlrvyig sfwaqplqnt
      181 dnrrlfeaea qdlfrdiqsl pqkaavrkln dlikrarlak vhayiisylk kempsvfgke
      241 nkkrelisrl peiyiqlqre yqisagdfpe vkamqeqlen ydftkfhslk pklieavdnm
      301 lsnkisplmn lisqeetstp tqlvqggafd gttegpfnqg ygegakegad eeewvvakdk
      361 pvydelfytl spingkisgv nakkemvtsk lpnsvlgkiw kladcdcdgm ldeeefalak
      421 hlikikldgy elpsslpphl vppshrkslp kad
//
LOCUS       XP_011519790             749 aa            linear   PRI 05-AUG-2025
DEFINITION  amyloid-beta A4 precursor protein-binding family A member 2 isoform
            X1 [Homo sapiens].
ACCESSION   XP_011519790
VERSION     XP_011519790.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521488.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..749
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..749
                     /product="amyloid-beta A4 precursor protein-binding family
                     A member 2 isoform X1"
                     /calculated_mol_wt=82381
     Region          363..535
                     /region_name="PTB_X11"
                     /note="X11-like Phosphotyrosine-binding (PTB) domain;
                     cd01208"
                     /db_xref="CDD:269919"
     Site            order(375,465,505)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:269919"
     Site            order(393,454,457..462,513,524,527)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:269919"
     Region          567..652
                     /region_name="PDZ1_APBA1_3-like"
                     /note="PDZ domain 1 of amyloid-beta A4 precursor
                     protein-binding family A member 1 (APBA1), APBA2, APBA3,
                     and related domains; cd06720"
                     /db_xref="CDD:467203"
     Site            order(578..584,598,601,631,635,638..639)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467203"
     Region          656..733
                     /region_name="PDZ2_APBA1_3-like"
                     /note="PDZ domain 2 of amyloid-beta A4 precursor
                     protein-binding family A member 1 (APBA1), APBA2, APBA3,
                     and related domains; cd06793"
                     /db_xref="CDD:467255"
     Site            order(670..676,681,684,713,717,720..721)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467255"
     CDS             1..749
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /coded_by="XM_011521488.4:268..2517"
                     /db_xref="GeneID:321"
                     /db_xref="HGNC:HGNC:579"
                     /db_xref="MIM:602712"
ORIGIN      
        1 mahrklesvg sgmldhrvrp gpvphsqepe sedmelpleg yvpeglelaa lrpespapee
       61 qechnhspdg dsssdyvnnt seeedydegl peeeegityy irycpeddsy legmdcngee
      121 ylahsahpvd tdecqeavee wtdsagphph gheaegsqdy pdgqlpiped epsvleahdq
      181 eedghycask egyqdyypee angntgaspy rlrrgdgdle dqeedidqiv aeikmslsmt
      241 sitsaseasp ehgpepgped sveacppika scspsrhear pkslnllpea khpgdpqrgf
      301 kpktrtpeer lkwpheqvcn gleqprkqqr sdlngpvdnn nipetkkvas fpsfvavpgp
      361 cepedlidgi ifaanylgst qllsernpsk nirmmqaqea vsrvkrmqka akikkkanse
      421 gdaqtltevd lfistqrikv lnadtqetmm dhalrtisyi adignivvlm arrrmprsas
      481 qdciettpga qegkkqykmi chvfesedaq liaqsigqaf svayqeflra nginpedlsq
      541 keysdiintq emynddlihf snsenckelq lekhkgeilg vvvvesgwgs ilptvilanm
      601 mnggpaarsg klsigdqims ingtslvglp latcqgiikg lknqtqvkln ivscppvttv
      661 likrpdlkyq lgfsvqngii cslmrggiae rggvrvghri ieingqsvva tahekivqal
      721 snsvgeihmk tmpaamfrll tgqetplyi
//
LOCUS       XP_047288365             749 aa            linear   PRI 05-AUG-2025
DEFINITION  amyloid-beta A4 precursor protein-binding family A member 2 isoform
            X1 [Homo sapiens].
ACCESSION   XP_047288365
VERSION     XP_047288365.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432409.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..749
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..749
                     /product="amyloid-beta A4 precursor protein-binding family
                     A member 2 isoform X1"
                     /calculated_mol_wt=82381
     Region          363..535
                     /region_name="PTB_X11"
                     /note="X11-like Phosphotyrosine-binding (PTB) domain;
                     cd01208"
                     /db_xref="CDD:269919"
     Site            order(375,465,505)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:269919"
     Site            order(393,454,457..462,513,524,527)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:269919"
     Region          567..652
                     /region_name="PDZ1_APBA1_3-like"
                     /note="PDZ domain 1 of amyloid-beta A4 precursor
                     protein-binding family A member 1 (APBA1), APBA2, APBA3,
                     and related domains; cd06720"
                     /db_xref="CDD:467203"
     Site            order(578..584,598,601,631,635,638..639)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467203"
     Region          656..733
                     /region_name="PDZ2_APBA1_3-like"
                     /note="PDZ domain 2 of amyloid-beta A4 precursor
                     protein-binding family A member 1 (APBA1), APBA2, APBA3,
                     and related domains; cd06793"
                     /db_xref="CDD:467255"
     Site            order(670..676,681,684,713,717,720..721)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467255"
     CDS             1..749
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /coded_by="XM_047432409.1:506..2755"
                     /db_xref="GeneID:321"
                     /db_xref="HGNC:HGNC:579"
                     /db_xref="MIM:602712"
ORIGIN      
        1 mahrklesvg sgmldhrvrp gpvphsqepe sedmelpleg yvpeglelaa lrpespapee
       61 qechnhspdg dsssdyvnnt seeedydegl peeeegityy irycpeddsy legmdcngee
      121 ylahsahpvd tdecqeavee wtdsagphph gheaegsqdy pdgqlpiped epsvleahdq
      181 eedghycask egyqdyypee angntgaspy rlrrgdgdle dqeedidqiv aeikmslsmt
      241 sitsaseasp ehgpepgped sveacppika scspsrhear pkslnllpea khpgdpqrgf
      301 kpktrtpeer lkwpheqvcn gleqprkqqr sdlngpvdnn nipetkkvas fpsfvavpgp
      361 cepedlidgi ifaanylgst qllsernpsk nirmmqaqea vsrvkrmqka akikkkanse
      421 gdaqtltevd lfistqrikv lnadtqetmm dhalrtisyi adignivvlm arrrmprsas
      481 qdciettpga qegkkqykmi chvfesedaq liaqsigqaf svayqeflra nginpedlsq
      541 keysdiintq emynddlihf snsenckelq lekhkgeilg vvvvesgwgs ilptvilanm
      601 mnggpaarsg klsigdqims ingtslvglp latcqgiikg lknqtqvkln ivscppvttv
      661 likrpdlkyq lgfsvqngii cslmrggiae rggvrvghri ieingqsvva tahekivqal
      721 snsvgeihmk tmpaamfrll tgqetplyi
//
LOCUS       XP_011519793             749 aa            linear   PRI 05-AUG-2025
DEFINITION  amyloid-beta A4 precursor protein-binding family A member 2 isoform
            X1 [Homo sapiens].
ACCESSION   XP_011519793
VERSION     XP_011519793.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521491.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..749
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..749
                     /product="amyloid-beta A4 precursor protein-binding family
                     A member 2 isoform X1"
                     /calculated_mol_wt=82381
     Region          363..535
                     /region_name="PTB_X11"
                     /note="X11-like Phosphotyrosine-binding (PTB) domain;
                     cd01208"
                     /db_xref="CDD:269919"
     Site            order(375,465,505)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:269919"
     Site            order(393,454,457..462,513,524,527)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:269919"
     Region          567..652
                     /region_name="PDZ1_APBA1_3-like"
                     /note="PDZ domain 1 of amyloid-beta A4 precursor
                     protein-binding family A member 1 (APBA1), APBA2, APBA3,
                     and related domains; cd06720"
                     /db_xref="CDD:467203"
     Site            order(578..584,598,601,631,635,638..639)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467203"
     Region          656..733
                     /region_name="PDZ2_APBA1_3-like"
                     /note="PDZ domain 2 of amyloid-beta A4 precursor
                     protein-binding family A member 1 (APBA1), APBA2, APBA3,
                     and related domains; cd06793"
                     /db_xref="CDD:467255"
     Site            order(670..676,681,684,713,717,720..721)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467255"
     CDS             1..749
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /coded_by="XM_011521491.2:209..2458"
                     /db_xref="GeneID:321"
                     /db_xref="HGNC:HGNC:579"
                     /db_xref="MIM:602712"
ORIGIN      
        1 mahrklesvg sgmldhrvrp gpvphsqepe sedmelpleg yvpeglelaa lrpespapee
       61 qechnhspdg dsssdyvnnt seeedydegl peeeegityy irycpeddsy legmdcngee
      121 ylahsahpvd tdecqeavee wtdsagphph gheaegsqdy pdgqlpiped epsvleahdq
      181 eedghycask egyqdyypee angntgaspy rlrrgdgdle dqeedidqiv aeikmslsmt
      241 sitsaseasp ehgpepgped sveacppika scspsrhear pkslnllpea khpgdpqrgf
      301 kpktrtpeer lkwpheqvcn gleqprkqqr sdlngpvdnn nipetkkvas fpsfvavpgp
      361 cepedlidgi ifaanylgst qllsernpsk nirmmqaqea vsrvkrmqka akikkkanse
      421 gdaqtltevd lfistqrikv lnadtqetmm dhalrtisyi adignivvlm arrrmprsas
      481 qdciettpga qegkkqykmi chvfesedaq liaqsigqaf svayqeflra nginpedlsq
      541 keysdiintq emynddlihf snsenckelq lekhkgeilg vvvvesgwgs ilptvilanm
      601 mnggpaarsg klsigdqims ingtslvglp latcqgiikg lknqtqvkln ivscppvttv
      661 likrpdlkyq lgfsvqngii cslmrggiae rggvrvghri ieingqsvva tahekivqal
      721 snsvgeihmk tmpaamfrll tgqetplyi
//
LOCUS       XP_016877601             749 aa            linear   PRI 05-AUG-2025
DEFINITION  amyloid-beta A4 precursor protein-binding family A member 2 isoform
            X1 [Homo sapiens].
ACCESSION   XP_016877601
VERSION     XP_016877601.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022112.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..749
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..749
                     /product="amyloid-beta A4 precursor protein-binding family
                     A member 2 isoform X1"
                     /calculated_mol_wt=82381
     Region          363..535
                     /region_name="PTB_X11"
                     /note="X11-like Phosphotyrosine-binding (PTB) domain;
                     cd01208"
                     /db_xref="CDD:269919"
     Site            order(375,465,505)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:269919"
     Site            order(393,454,457..462,513,524,527)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:269919"
     Region          567..652
                     /region_name="PDZ1_APBA1_3-like"
                     /note="PDZ domain 1 of amyloid-beta A4 precursor
                     protein-binding family A member 1 (APBA1), APBA2, APBA3,
                     and related domains; cd06720"
                     /db_xref="CDD:467203"
     Site            order(578..584,598,601,631,635,638..639)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467203"
     Region          656..733
                     /region_name="PDZ2_APBA1_3-like"
                     /note="PDZ domain 2 of amyloid-beta A4 precursor
                     protein-binding family A member 1 (APBA1), APBA2, APBA3,
                     and related domains; cd06793"
                     /db_xref="CDD:467255"
     Site            order(670..676,681,684,713,717,720..721)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467255"
     CDS             1..749
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /coded_by="XM_017022112.3:399..2648"
                     /db_xref="GeneID:321"
                     /db_xref="HGNC:HGNC:579"
                     /db_xref="MIM:602712"
ORIGIN      
        1 mahrklesvg sgmldhrvrp gpvphsqepe sedmelpleg yvpeglelaa lrpespapee
       61 qechnhspdg dsssdyvnnt seeedydegl peeeegityy irycpeddsy legmdcngee
      121 ylahsahpvd tdecqeavee wtdsagphph gheaegsqdy pdgqlpiped epsvleahdq
      181 eedghycask egyqdyypee angntgaspy rlrrgdgdle dqeedidqiv aeikmslsmt
      241 sitsaseasp ehgpepgped sveacppika scspsrhear pkslnllpea khpgdpqrgf
      301 kpktrtpeer lkwpheqvcn gleqprkqqr sdlngpvdnn nipetkkvas fpsfvavpgp
      361 cepedlidgi ifaanylgst qllsernpsk nirmmqaqea vsrvkrmqka akikkkanse
      421 gdaqtltevd lfistqrikv lnadtqetmm dhalrtisyi adignivvlm arrrmprsas
      481 qdciettpga qegkkqykmi chvfesedaq liaqsigqaf svayqeflra nginpedlsq
      541 keysdiintq emynddlihf snsenckelq lekhkgeilg vvvvesgwgs ilptvilanm
      601 mnggpaarsg klsigdqims ingtslvglp latcqgiikg lknqtqvkln ivscppvttv
      661 likrpdlkyq lgfsvqngii cslmrggiae rggvrvghri ieingqsvva tahekivqal
      721 snsvgeihmk tmpaamfrll tgqetplyi
//
LOCUS       XP_047288366             749 aa            linear   PRI 05-AUG-2025
DEFINITION  amyloid-beta A4 precursor protein-binding family A member 2 isoform
            X1 [Homo sapiens].
ACCESSION   XP_047288366
VERSION     XP_047288366.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432410.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..749
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..749
                     /product="amyloid-beta A4 precursor protein-binding family
                     A member 2 isoform X1"
                     /calculated_mol_wt=82381
     Region          363..535
                     /region_name="PTB_X11"
                     /note="X11-like Phosphotyrosine-binding (PTB) domain;
                     cd01208"
                     /db_xref="CDD:269919"
     Site            order(375,465,505)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:269919"
     Site            order(393,454,457..462,513,524,527)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:269919"
     Region          567..652
                     /region_name="PDZ1_APBA1_3-like"
                     /note="PDZ domain 1 of amyloid-beta A4 precursor
                     protein-binding family A member 1 (APBA1), APBA2, APBA3,
                     and related domains; cd06720"
                     /db_xref="CDD:467203"
     Site            order(578..584,598,601,631,635,638..639)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467203"
     Region          656..733
                     /region_name="PDZ2_APBA1_3-like"
                     /note="PDZ domain 2 of amyloid-beta A4 precursor
                     protein-binding family A member 1 (APBA1), APBA2, APBA3,
                     and related domains; cd06793"
                     /db_xref="CDD:467255"
     Site            order(670..676,681,684,713,717,720..721)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467255"
     CDS             1..749
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /coded_by="XM_047432410.1:378..2627"
                     /db_xref="GeneID:321"
                     /db_xref="HGNC:HGNC:579"
                     /db_xref="MIM:602712"
ORIGIN      
        1 mahrklesvg sgmldhrvrp gpvphsqepe sedmelpleg yvpeglelaa lrpespapee
       61 qechnhspdg dsssdyvnnt seeedydegl peeeegityy irycpeddsy legmdcngee
      121 ylahsahpvd tdecqeavee wtdsagphph gheaegsqdy pdgqlpiped epsvleahdq
      181 eedghycask egyqdyypee angntgaspy rlrrgdgdle dqeedidqiv aeikmslsmt
      241 sitsaseasp ehgpepgped sveacppika scspsrhear pkslnllpea khpgdpqrgf
      301 kpktrtpeer lkwpheqvcn gleqprkqqr sdlngpvdnn nipetkkvas fpsfvavpgp
      361 cepedlidgi ifaanylgst qllsernpsk nirmmqaqea vsrvkrmqka akikkkanse
      421 gdaqtltevd lfistqrikv lnadtqetmm dhalrtisyi adignivvlm arrrmprsas
      481 qdciettpga qegkkqykmi chvfesedaq liaqsigqaf svayqeflra nginpedlsq
      541 keysdiintq emynddlihf snsenckelq lekhkgeilg vvvvesgwgs ilptvilanm
      601 mnggpaarsg klsigdqims ingtslvglp latcqgiikg lknqtqvkln ivscppvttv
      661 likrpdlkyq lgfsvqngii cslmrggiae rggvrvghri ieingqsvva tahekivqal
      721 snsvgeihmk tmpaamfrll tgqetplyi
//
LOCUS       XP_047288367             749 aa            linear   PRI 05-AUG-2025
DEFINITION  amyloid-beta A4 precursor protein-binding family A member 2 isoform
            X1 [Homo sapiens].
ACCESSION   XP_047288367
VERSION     XP_047288367.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432411.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..749
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..749
                     /product="amyloid-beta A4 precursor protein-binding family
                     A member 2 isoform X1"
                     /calculated_mol_wt=82381
     Region          363..535
                     /region_name="PTB_X11"
                     /note="X11-like Phosphotyrosine-binding (PTB) domain;
                     cd01208"
                     /db_xref="CDD:269919"
     Site            order(375,465,505)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:269919"
     Site            order(393,454,457..462,513,524,527)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:269919"
     Region          567..652
                     /region_name="PDZ1_APBA1_3-like"
                     /note="PDZ domain 1 of amyloid-beta A4 precursor
                     protein-binding family A member 1 (APBA1), APBA2, APBA3,
                     and related domains; cd06720"
                     /db_xref="CDD:467203"
     Site            order(578..584,598,601,631,635,638..639)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467203"
     Region          656..733
                     /region_name="PDZ2_APBA1_3-like"
                     /note="PDZ domain 2 of amyloid-beta A4 precursor
                     protein-binding family A member 1 (APBA1), APBA2, APBA3,
                     and related domains; cd06793"
                     /db_xref="CDD:467255"
     Site            order(670..676,681,684,713,717,720..721)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467255"
     CDS             1..749
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /coded_by="XM_047432411.1:475..2724"
                     /db_xref="GeneID:321"
                     /db_xref="HGNC:HGNC:579"
                     /db_xref="MIM:602712"
ORIGIN      
        1 mahrklesvg sgmldhrvrp gpvphsqepe sedmelpleg yvpeglelaa lrpespapee
       61 qechnhspdg dsssdyvnnt seeedydegl peeeegityy irycpeddsy legmdcngee
      121 ylahsahpvd tdecqeavee wtdsagphph gheaegsqdy pdgqlpiped epsvleahdq
      181 eedghycask egyqdyypee angntgaspy rlrrgdgdle dqeedidqiv aeikmslsmt
      241 sitsaseasp ehgpepgped sveacppika scspsrhear pkslnllpea khpgdpqrgf
      301 kpktrtpeer lkwpheqvcn gleqprkqqr sdlngpvdnn nipetkkvas fpsfvavpgp
      361 cepedlidgi ifaanylgst qllsernpsk nirmmqaqea vsrvkrmqka akikkkanse
      421 gdaqtltevd lfistqrikv lnadtqetmm dhalrtisyi adignivvlm arrrmprsas
      481 qdciettpga qegkkqykmi chvfesedaq liaqsigqaf svayqeflra nginpedlsq
      541 keysdiintq emynddlihf snsenckelq lekhkgeilg vvvvesgwgs ilptvilanm
      601 mnggpaarsg klsigdqims ingtslvglp latcqgiikg lknqtqvkln ivscppvttv
      661 likrpdlkyq lgfsvqngii cslmrggiae rggvrvghri ieingqsvva tahekivqal
      721 snsvgeihmk tmpaamfrll tgqetplyi
//
LOCUS       XP_011519791             749 aa            linear   PRI 05-AUG-2025
DEFINITION  amyloid-beta A4 precursor protein-binding family A member 2 isoform
            X1 [Homo sapiens].
ACCESSION   XP_011519791
VERSION     XP_011519791.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521489.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..749
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..749
                     /product="amyloid-beta A4 precursor protein-binding family
                     A member 2 isoform X1"
                     /calculated_mol_wt=82381
     Region          363..535
                     /region_name="PTB_X11"
                     /note="X11-like Phosphotyrosine-binding (PTB) domain;
                     cd01208"
                     /db_xref="CDD:269919"
     Site            order(375,465,505)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:269919"
     Site            order(393,454,457..462,513,524,527)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:269919"
     Region          567..652
                     /region_name="PDZ1_APBA1_3-like"
                     /note="PDZ domain 1 of amyloid-beta A4 precursor
                     protein-binding family A member 1 (APBA1), APBA2, APBA3,
                     and related domains; cd06720"
                     /db_xref="CDD:467203"
     Site            order(578..584,598,601,631,635,638..639)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467203"
     Region          656..733
                     /region_name="PDZ2_APBA1_3-like"
                     /note="PDZ domain 2 of amyloid-beta A4 precursor
                     protein-binding family A member 1 (APBA1), APBA2, APBA3,
                     and related domains; cd06793"
                     /db_xref="CDD:467255"
     Site            order(670..676,681,684,713,717,720..721)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467255"
     CDS             1..749
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /coded_by="XM_011521489.3:700..2949"
                     /db_xref="GeneID:321"
                     /db_xref="HGNC:HGNC:579"
                     /db_xref="MIM:602712"
ORIGIN      
        1 mahrklesvg sgmldhrvrp gpvphsqepe sedmelpleg yvpeglelaa lrpespapee
       61 qechnhspdg dsssdyvnnt seeedydegl peeeegityy irycpeddsy legmdcngee
      121 ylahsahpvd tdecqeavee wtdsagphph gheaegsqdy pdgqlpiped epsvleahdq
      181 eedghycask egyqdyypee angntgaspy rlrrgdgdle dqeedidqiv aeikmslsmt
      241 sitsaseasp ehgpepgped sveacppika scspsrhear pkslnllpea khpgdpqrgf
      301 kpktrtpeer lkwpheqvcn gleqprkqqr sdlngpvdnn nipetkkvas fpsfvavpgp
      361 cepedlidgi ifaanylgst qllsernpsk nirmmqaqea vsrvkrmqka akikkkanse
      421 gdaqtltevd lfistqrikv lnadtqetmm dhalrtisyi adignivvlm arrrmprsas
      481 qdciettpga qegkkqykmi chvfesedaq liaqsigqaf svayqeflra nginpedlsq
      541 keysdiintq emynddlihf snsenckelq lekhkgeilg vvvvesgwgs ilptvilanm
      601 mnggpaarsg klsigdqims ingtslvglp latcqgiikg lknqtqvkln ivscppvttv
      661 likrpdlkyq lgfsvqngii cslmrggiae rggvrvghri ieingqsvva tahekivqal
      721 snsvgeihmk tmpaamfrll tgqetplyi
//
LOCUS       XP_047288368             749 aa            linear   PRI 05-AUG-2025
DEFINITION  amyloid-beta A4 precursor protein-binding family A member 2 isoform
            X1 [Homo sapiens].
ACCESSION   XP_047288368
VERSION     XP_047288368.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432412.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..749
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..749
                     /product="amyloid-beta A4 precursor protein-binding family
                     A member 2 isoform X1"
                     /calculated_mol_wt=82381
     Region          363..535
                     /region_name="PTB_X11"
                     /note="X11-like Phosphotyrosine-binding (PTB) domain;
                     cd01208"
                     /db_xref="CDD:269919"
     Site            order(375,465,505)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:269919"
     Site            order(393,454,457..462,513,524,527)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:269919"
     Region          567..652
                     /region_name="PDZ1_APBA1_3-like"
                     /note="PDZ domain 1 of amyloid-beta A4 precursor
                     protein-binding family A member 1 (APBA1), APBA2, APBA3,
                     and related domains; cd06720"
                     /db_xref="CDD:467203"
     Site            order(578..584,598,601,631,635,638..639)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467203"
     Region          656..733
                     /region_name="PDZ2_APBA1_3-like"
                     /note="PDZ domain 2 of amyloid-beta A4 precursor
                     protein-binding family A member 1 (APBA1), APBA2, APBA3,
                     and related domains; cd06793"
                     /db_xref="CDD:467255"
     Site            order(670..676,681,684,713,717,720..721)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467255"
     CDS             1..749
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /coded_by="XM_047432412.1:291..2540"
                     /db_xref="GeneID:321"
                     /db_xref="HGNC:HGNC:579"
                     /db_xref="MIM:602712"
ORIGIN      
        1 mahrklesvg sgmldhrvrp gpvphsqepe sedmelpleg yvpeglelaa lrpespapee
       61 qechnhspdg dsssdyvnnt seeedydegl peeeegityy irycpeddsy legmdcngee
      121 ylahsahpvd tdecqeavee wtdsagphph gheaegsqdy pdgqlpiped epsvleahdq
      181 eedghycask egyqdyypee angntgaspy rlrrgdgdle dqeedidqiv aeikmslsmt
      241 sitsaseasp ehgpepgped sveacppika scspsrhear pkslnllpea khpgdpqrgf
      301 kpktrtpeer lkwpheqvcn gleqprkqqr sdlngpvdnn nipetkkvas fpsfvavpgp
      361 cepedlidgi ifaanylgst qllsernpsk nirmmqaqea vsrvkrmqka akikkkanse
      421 gdaqtltevd lfistqrikv lnadtqetmm dhalrtisyi adignivvlm arrrmprsas
      481 qdciettpga qegkkqykmi chvfesedaq liaqsigqaf svayqeflra nginpedlsq
      541 keysdiintq emynddlihf snsenckelq lekhkgeilg vvvvesgwgs ilptvilanm
      601 mnggpaarsg klsigdqims ingtslvglp latcqgiikg lknqtqvkln ivscppvttv
      661 likrpdlkyq lgfsvqngii cslmrggiae rggvrvghri ieingqsvva tahekivqal
      721 snsvgeihmk tmpaamfrll tgqetplyi
//
LOCUS       XP_011519792             749 aa            linear   PRI 05-AUG-2025
DEFINITION  amyloid-beta A4 precursor protein-binding family A member 2 isoform
            X1 [Homo sapiens].
ACCESSION   XP_011519792
VERSION     XP_011519792.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521490.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..749
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..749
                     /product="amyloid-beta A4 precursor protein-binding family
                     A member 2 isoform X1"
                     /calculated_mol_wt=82381
     Region          363..535
                     /region_name="PTB_X11"
                     /note="X11-like Phosphotyrosine-binding (PTB) domain;
                     cd01208"
                     /db_xref="CDD:269919"
     Site            order(375,465,505)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:269919"
     Site            order(393,454,457..462,513,524,527)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:269919"
     Region          567..652
                     /region_name="PDZ1_APBA1_3-like"
                     /note="PDZ domain 1 of amyloid-beta A4 precursor
                     protein-binding family A member 1 (APBA1), APBA2, APBA3,
                     and related domains; cd06720"
                     /db_xref="CDD:467203"
     Site            order(578..584,598,601,631,635,638..639)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467203"
     Region          656..733
                     /region_name="PDZ2_APBA1_3-like"
                     /note="PDZ domain 2 of amyloid-beta A4 precursor
                     protein-binding family A member 1 (APBA1), APBA2, APBA3,
                     and related domains; cd06793"
                     /db_xref="CDD:467255"
     Site            order(670..676,681,684,713,717,720..721)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467255"
     CDS             1..749
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /coded_by="XM_011521490.3:669..2918"
                     /db_xref="GeneID:321"
                     /db_xref="HGNC:HGNC:579"
                     /db_xref="MIM:602712"
ORIGIN      
        1 mahrklesvg sgmldhrvrp gpvphsqepe sedmelpleg yvpeglelaa lrpespapee
       61 qechnhspdg dsssdyvnnt seeedydegl peeeegityy irycpeddsy legmdcngee
      121 ylahsahpvd tdecqeavee wtdsagphph gheaegsqdy pdgqlpiped epsvleahdq
      181 eedghycask egyqdyypee angntgaspy rlrrgdgdle dqeedidqiv aeikmslsmt
      241 sitsaseasp ehgpepgped sveacppika scspsrhear pkslnllpea khpgdpqrgf
      301 kpktrtpeer lkwpheqvcn gleqprkqqr sdlngpvdnn nipetkkvas fpsfvavpgp
      361 cepedlidgi ifaanylgst qllsernpsk nirmmqaqea vsrvkrmqka akikkkanse
      421 gdaqtltevd lfistqrikv lnadtqetmm dhalrtisyi adignivvlm arrrmprsas
      481 qdciettpga qegkkqykmi chvfesedaq liaqsigqaf svayqeflra nginpedlsq
      541 keysdiintq emynddlihf snsenckelq lekhkgeilg vvvvesgwgs ilptvilanm
      601 mnggpaarsg klsigdqims ingtslvglp latcqgiikg lknqtqvkln ivscppvttv
      661 likrpdlkyq lgfsvqngii cslmrggiae rggvrvghri ieingqsvva tahekivqal
      721 snsvgeihmk tmpaamfrll tgqetplyi
//
LOCUS       XP_011519794             749 aa            linear   PRI 05-AUG-2025
DEFINITION  amyloid-beta A4 precursor protein-binding family A member 2 isoform
            X1 [Homo sapiens].
ACCESSION   XP_011519794
VERSION     XP_011519794.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521492.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..749
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..749
                     /product="amyloid-beta A4 precursor protein-binding family
                     A member 2 isoform X1"
                     /calculated_mol_wt=82381
     Region          363..535
                     /region_name="PTB_X11"
                     /note="X11-like Phosphotyrosine-binding (PTB) domain;
                     cd01208"
                     /db_xref="CDD:269919"
     Site            order(375,465,505)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:269919"
     Site            order(393,454,457..462,513,524,527)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:269919"
     Region          567..652
                     /region_name="PDZ1_APBA1_3-like"
                     /note="PDZ domain 1 of amyloid-beta A4 precursor
                     protein-binding family A member 1 (APBA1), APBA2, APBA3,
                     and related domains; cd06720"
                     /db_xref="CDD:467203"
     Site            order(578..584,598,601,631,635,638..639)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467203"
     Region          656..733
                     /region_name="PDZ2_APBA1_3-like"
                     /note="PDZ domain 2 of amyloid-beta A4 precursor
                     protein-binding family A member 1 (APBA1), APBA2, APBA3,
                     and related domains; cd06793"
                     /db_xref="CDD:467255"
     Site            order(670..676,681,684,713,717,720..721)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467255"
     CDS             1..749
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /coded_by="XM_011521492.3:474..2723"
                     /db_xref="GeneID:321"
                     /db_xref="HGNC:HGNC:579"
                     /db_xref="MIM:602712"
ORIGIN      
        1 mahrklesvg sgmldhrvrp gpvphsqepe sedmelpleg yvpeglelaa lrpespapee
       61 qechnhspdg dsssdyvnnt seeedydegl peeeegityy irycpeddsy legmdcngee
      121 ylahsahpvd tdecqeavee wtdsagphph gheaegsqdy pdgqlpiped epsvleahdq
      181 eedghycask egyqdyypee angntgaspy rlrrgdgdle dqeedidqiv aeikmslsmt
      241 sitsaseasp ehgpepgped sveacppika scspsrhear pkslnllpea khpgdpqrgf
      301 kpktrtpeer lkwpheqvcn gleqprkqqr sdlngpvdnn nipetkkvas fpsfvavpgp
      361 cepedlidgi ifaanylgst qllsernpsk nirmmqaqea vsrvkrmqka akikkkanse
      421 gdaqtltevd lfistqrikv lnadtqetmm dhalrtisyi adignivvlm arrrmprsas
      481 qdciettpga qegkkqykmi chvfesedaq liaqsigqaf svayqeflra nginpedlsq
      541 keysdiintq emynddlihf snsenckelq lekhkgeilg vvvvesgwgs ilptvilanm
      601 mnggpaarsg klsigdqims ingtslvglp latcqgiikg lknqtqvkln ivscppvttv
      661 likrpdlkyq lgfsvqngii cslmrggiae rggvrvghri ieingqsvva tahekivqal
      721 snsvgeihmk tmpaamfrll tgqetplyi
//
LOCUS       XP_047288369             739 aa            linear   PRI 05-AUG-2025
DEFINITION  amyloid-beta A4 precursor protein-binding family A member 2 isoform
            X2 [Homo sapiens].
ACCESSION   XP_047288369
VERSION     XP_047288369.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432413.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..739
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..739
                     /product="amyloid-beta A4 precursor protein-binding family
                     A member 2 isoform X2"
                     /calculated_mol_wt=81227
     Region          363..525
                     /region_name="PTB_X11"
                     /note="X11-like Phosphotyrosine-binding (PTB) domain;
                     cd01208"
                     /db_xref="CDD:269919"
     Site            order(375,455,495)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:269919"
     Site            order(393,444,447..452,503,514,517)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:269919"
     Region          557..642
                     /region_name="PDZ1_APBA1_3-like"
                     /note="PDZ domain 1 of amyloid-beta A4 precursor
                     protein-binding family A member 1 (APBA1), APBA2, APBA3,
                     and related domains; cd06720"
                     /db_xref="CDD:467203"
     Site            order(568..574,588,591,621,625,628..629)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467203"
     Region          646..723
                     /region_name="PDZ2_APBA1_3-like"
                     /note="PDZ domain 2 of amyloid-beta A4 precursor
                     protein-binding family A member 1 (APBA1), APBA2, APBA3,
                     and related domains; cd06793"
                     /db_xref="CDD:467255"
     Site            order(660..666,671,674,703,707,710..711)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467255"
     CDS             1..739
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /coded_by="XM_047432413.1:378..2597"
                     /db_xref="GeneID:321"
                     /db_xref="HGNC:HGNC:579"
                     /db_xref="MIM:602712"
ORIGIN      
        1 mahrklesvg sgmldhrvrp gpvphsqepe sedmelpleg yvpeglelaa lrpespapee
       61 qechnhspdg dsssdyvnnt seeedydegl peeeegityy irycpeddsy legmdcngee
      121 ylahsahpvd tdecqeavee wtdsagphph gheaegsqdy pdgqlpiped epsvleahdq
      181 eedghycask egyqdyypee angntgaspy rlrrgdgdle dqeedidqiv aeikmslsmt
      241 sitsaseasp ehgpepgped sveacppika scspsrhear pkslnllpea khpgdpqrgf
      301 kpktrtpeer lkwpheqvcn gleqprkqqr sdlngpvdnn nipetkkvas fpsfvavpgp
      361 cepedlidgi ifaanylgst qllsernpsk nirmmqaqea vsrvkvense gdaqtltevd
      421 lfistqrikv lnadtqetmm dhalrtisyi adignivvlm arrrmprsas qdciettpga
      481 qegkkqykmi chvfesedaq liaqsigqaf svayqeflra nginpedlsq keysdiintq
      541 emynddlihf snsenckelq lekhkgeilg vvvvesgwgs ilptvilanm mnggpaarsg
      601 klsigdqims ingtslvglp latcqgiikg lknqtqvkln ivscppvttv likrpdlkyq
      661 lgfsvqngii cslmrggiae rggvrvghri ieingqsvva tahekivqal snsvgeihmk
      721 tmpaamfrll tgqetplyi
//
LOCUS       XP_024305677             739 aa            linear   PRI 05-AUG-2025
DEFINITION  amyloid-beta A4 precursor protein-binding family A member 2 isoform
            X2 [Homo sapiens].
ACCESSION   XP_024305677
VERSION     XP_024305677.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449909.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..739
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..739
                     /product="amyloid-beta A4 precursor protein-binding family
                     A member 2 isoform X2"
                     /calculated_mol_wt=81227
     Region          363..525
                     /region_name="PTB_X11"
                     /note="X11-like Phosphotyrosine-binding (PTB) domain;
                     cd01208"
                     /db_xref="CDD:269919"
     Site            order(375,455,495)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:269919"
     Site            order(393,444,447..452,503,514,517)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:269919"
     Region          557..642
                     /region_name="PDZ1_APBA1_3-like"
                     /note="PDZ domain 1 of amyloid-beta A4 precursor
                     protein-binding family A member 1 (APBA1), APBA2, APBA3,
                     and related domains; cd06720"
                     /db_xref="CDD:467203"
     Site            order(568..574,588,591,621,625,628..629)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467203"
     Region          646..723
                     /region_name="PDZ2_APBA1_3-like"
                     /note="PDZ domain 2 of amyloid-beta A4 precursor
                     protein-binding family A member 1 (APBA1), APBA2, APBA3,
                     and related domains; cd06793"
                     /db_xref="CDD:467255"
     Site            order(660..666,671,674,703,707,710..711)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467255"
     CDS             1..739
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /coded_by="XM_024449909.2:479..2698"
                     /db_xref="GeneID:321"
                     /db_xref="HGNC:HGNC:579"
                     /db_xref="MIM:602712"
ORIGIN      
        1 mahrklesvg sgmldhrvrp gpvphsqepe sedmelpleg yvpeglelaa lrpespapee
       61 qechnhspdg dsssdyvnnt seeedydegl peeeegityy irycpeddsy legmdcngee
      121 ylahsahpvd tdecqeavee wtdsagphph gheaegsqdy pdgqlpiped epsvleahdq
      181 eedghycask egyqdyypee angntgaspy rlrrgdgdle dqeedidqiv aeikmslsmt
      241 sitsaseasp ehgpepgped sveacppika scspsrhear pkslnllpea khpgdpqrgf
      301 kpktrtpeer lkwpheqvcn gleqprkqqr sdlngpvdnn nipetkkvas fpsfvavpgp
      361 cepedlidgi ifaanylgst qllsernpsk nirmmqaqea vsrvkvense gdaqtltevd
      421 lfistqrikv lnadtqetmm dhalrtisyi adignivvlm arrrmprsas qdciettpga
      481 qegkkqykmi chvfesedaq liaqsigqaf svayqeflra nginpedlsq keysdiintq
      541 emynddlihf snsenckelq lekhkgeilg vvvvesgwgs ilptvilanm mnggpaarsg
      601 klsigdqims ingtslvglp latcqgiikg lknqtqvkln ivscppvttv likrpdlkyq
      661 lgfsvqngii cslmrggiae rggvrvghri ieingqsvva tahekivqal snsvgeihmk
      721 tmpaamfrll tgqetplyi
//
LOCUS       XP_047288370             737 aa            linear   PRI 05-AUG-2025
DEFINITION  amyloid-beta A4 precursor protein-binding family A member 2 isoform
            X3 [Homo sapiens].
ACCESSION   XP_047288370
VERSION     XP_047288370.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432414.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..737
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..737
                     /product="amyloid-beta A4 precursor protein-binding family
                     A member 2 isoform X3"
                     /calculated_mol_wt=80999
     Region          363..523
                     /region_name="PTB_X11"
                     /note="X11-like Phosphotyrosine-binding (PTB) domain;
                     cd01208"
                     /db_xref="CDD:269919"
     Site            order(375,453,493)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:269919"
     Site            order(393,442,445..450,501,512,515)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:269919"
     Region          555..640
                     /region_name="PDZ1_APBA1_3-like"
                     /note="PDZ domain 1 of amyloid-beta A4 precursor
                     protein-binding family A member 1 (APBA1), APBA2, APBA3,
                     and related domains; cd06720"
                     /db_xref="CDD:467203"
     Site            order(566..572,586,589,619,623,626..627)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467203"
     Region          644..721
                     /region_name="PDZ2_APBA1_3-like"
                     /note="PDZ domain 2 of amyloid-beta A4 precursor
                     protein-binding family A member 1 (APBA1), APBA2, APBA3,
                     and related domains; cd06793"
                     /db_xref="CDD:467255"
     Site            order(658..664,669,672,701,705,708..709)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467255"
     CDS             1..737
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /coded_by="XM_047432414.1:268..2481"
                     /db_xref="GeneID:321"
                     /db_xref="HGNC:HGNC:579"
                     /db_xref="MIM:602712"
ORIGIN      
        1 mahrklesvg sgmldhrvrp gpvphsqepe sedmelpleg yvpeglelaa lrpespapee
       61 qechnhspdg dsssdyvnnt seeedydegl peeeegityy irycpeddsy legmdcngee
      121 ylahsahpvd tdecqeavee wtdsagphph gheaegsqdy pdgqlpiped epsvleahdq
      181 eedghycask egyqdyypee angntgaspy rlrrgdgdle dqeedidqiv aeikmslsmt
      241 sitsaseasp ehgpepgped sveacppika scspsrhear pkslnllpea khpgdpqrgf
      301 kpktrtpeer lkwpheqvcn gleqprkqqr sdlngpvdnn nipetkkvas fpsfvavpgp
      361 cepedlidgi ifaanylgst qllsernpsk nirmmqaqea vsrvknsegd aqtltevdlf
      421 istqrikvln adtqetmmdh alrtisyiad ignivvlmar rrmprsasqd ciettpgaqe
      481 gkkqykmich vfesedaqli aqsigqafsv ayqeflrang inpedlsqke ysdiintqem
      541 ynddlihfsn senckelqle khkgeilgvv vvesgwgsil ptvilanmmn ggpaarsgkl
      601 sigdqimsin gtslvglpla tcqgiikglk nqtqvklniv scppvttvli krpdlkyqlg
      661 fsvqngiics lmrggiaerg gvrvghriie ingqsvvata hekivqalsn svgeihmktm
      721 paamfrlltg qetplyi
//
LOCUS       XP_047288371             737 aa            linear   PRI 05-AUG-2025
DEFINITION  amyloid-beta A4 precursor protein-binding family A member 2 isoform
            X3 [Homo sapiens].
ACCESSION   XP_047288371
VERSION     XP_047288371.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432415.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..737
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..737
                     /product="amyloid-beta A4 precursor protein-binding family
                     A member 2 isoform X3"
                     /calculated_mol_wt=80999
     Region          363..523
                     /region_name="PTB_X11"
                     /note="X11-like Phosphotyrosine-binding (PTB) domain;
                     cd01208"
                     /db_xref="CDD:269919"
     Site            order(375,453,493)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:269919"
     Site            order(393,442,445..450,501,512,515)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:269919"
     Region          555..640
                     /region_name="PDZ1_APBA1_3-like"
                     /note="PDZ domain 1 of amyloid-beta A4 precursor
                     protein-binding family A member 1 (APBA1), APBA2, APBA3,
                     and related domains; cd06720"
                     /db_xref="CDD:467203"
     Site            order(566..572,586,589,619,623,626..627)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467203"
     Region          644..721
                     /region_name="PDZ2_APBA1_3-like"
                     /note="PDZ domain 2 of amyloid-beta A4 precursor
                     protein-binding family A member 1 (APBA1), APBA2, APBA3,
                     and related domains; cd06793"
                     /db_xref="CDD:467255"
     Site            order(658..664,669,672,701,705,708..709)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467255"
     CDS             1..737
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /coded_by="XM_047432415.1:378..2591"
                     /db_xref="GeneID:321"
                     /db_xref="HGNC:HGNC:579"
                     /db_xref="MIM:602712"
ORIGIN      
        1 mahrklesvg sgmldhrvrp gpvphsqepe sedmelpleg yvpeglelaa lrpespapee
       61 qechnhspdg dsssdyvnnt seeedydegl peeeegityy irycpeddsy legmdcngee
      121 ylahsahpvd tdecqeavee wtdsagphph gheaegsqdy pdgqlpiped epsvleahdq
      181 eedghycask egyqdyypee angntgaspy rlrrgdgdle dqeedidqiv aeikmslsmt
      241 sitsaseasp ehgpepgped sveacppika scspsrhear pkslnllpea khpgdpqrgf
      301 kpktrtpeer lkwpheqvcn gleqprkqqr sdlngpvdnn nipetkkvas fpsfvavpgp
      361 cepedlidgi ifaanylgst qllsernpsk nirmmqaqea vsrvknsegd aqtltevdlf
      421 istqrikvln adtqetmmdh alrtisyiad ignivvlmar rrmprsasqd ciettpgaqe
      481 gkkqykmich vfesedaqli aqsigqafsv ayqeflrang inpedlsqke ysdiintqem
      541 ynddlihfsn senckelqle khkgeilgvv vvesgwgsil ptvilanmmn ggpaarsgkl
      601 sigdqimsin gtslvglpla tcqgiikglk nqtqvklniv scppvttvli krpdlkyqlg
      661 fsvqngiics lmrggiaerg gvrvghriie ingqsvvata hekivqalsn svgeihmktm
      721 paamfrlltg qetplyi
//
LOCUS       XP_047288372             737 aa            linear   PRI 05-AUG-2025
DEFINITION  amyloid-beta A4 precursor protein-binding family A member 2 isoform
            X3 [Homo sapiens].
ACCESSION   XP_047288372
VERSION     XP_047288372.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432416.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..737
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..737
                     /product="amyloid-beta A4 precursor protein-binding family
                     A member 2 isoform X3"
                     /calculated_mol_wt=80999
     Region          363..523
                     /region_name="PTB_X11"
                     /note="X11-like Phosphotyrosine-binding (PTB) domain;
                     cd01208"
                     /db_xref="CDD:269919"
     Site            order(375,453,493)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:269919"
     Site            order(393,442,445..450,501,512,515)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:269919"
     Region          555..640
                     /region_name="PDZ1_APBA1_3-like"
                     /note="PDZ domain 1 of amyloid-beta A4 precursor
                     protein-binding family A member 1 (APBA1), APBA2, APBA3,
                     and related domains; cd06720"
                     /db_xref="CDD:467203"
     Site            order(566..572,586,589,619,623,626..627)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467203"
     Region          644..721
                     /region_name="PDZ2_APBA1_3-like"
                     /note="PDZ domain 2 of amyloid-beta A4 precursor
                     protein-binding family A member 1 (APBA1), APBA2, APBA3,
                     and related domains; cd06793"
                     /db_xref="CDD:467255"
     Site            order(658..664,669,672,701,705,708..709)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467255"
     CDS             1..737
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /coded_by="XM_047432416.1:700..2913"
                     /db_xref="GeneID:321"
                     /db_xref="HGNC:HGNC:579"
                     /db_xref="MIM:602712"
ORIGIN      
        1 mahrklesvg sgmldhrvrp gpvphsqepe sedmelpleg yvpeglelaa lrpespapee
       61 qechnhspdg dsssdyvnnt seeedydegl peeeegityy irycpeddsy legmdcngee
      121 ylahsahpvd tdecqeavee wtdsagphph gheaegsqdy pdgqlpiped epsvleahdq
      181 eedghycask egyqdyypee angntgaspy rlrrgdgdle dqeedidqiv aeikmslsmt
      241 sitsaseasp ehgpepgped sveacppika scspsrhear pkslnllpea khpgdpqrgf
      301 kpktrtpeer lkwpheqvcn gleqprkqqr sdlngpvdnn nipetkkvas fpsfvavpgp
      361 cepedlidgi ifaanylgst qllsernpsk nirmmqaqea vsrvknsegd aqtltevdlf
      421 istqrikvln adtqetmmdh alrtisyiad ignivvlmar rrmprsasqd ciettpgaqe
      481 gkkqykmich vfesedaqli aqsigqafsv ayqeflrang inpedlsqke ysdiintqem
      541 ynddlihfsn senckelqle khkgeilgvv vvesgwgsil ptvilanmmn ggpaarsgkl
      601 sigdqimsin gtslvglpla tcqgiikglk nqtqvklniv scppvttvli krpdlkyqlg
      661 fsvqngiics lmrggiaerg gvrvghriie ingqsvvata hekivqalsn svgeihmktm
      721 paamfrlltg qetplyi
//
LOCUS       XP_047288373             737 aa            linear   PRI 05-AUG-2025
DEFINITION  amyloid-beta A4 precursor protein-binding family A member 2 isoform
            X3 [Homo sapiens].
ACCESSION   XP_047288373
VERSION     XP_047288373.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432417.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..737
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..737
                     /product="amyloid-beta A4 precursor protein-binding family
                     A member 2 isoform X3"
                     /calculated_mol_wt=80999
     Region          363..523
                     /region_name="PTB_X11"
                     /note="X11-like Phosphotyrosine-binding (PTB) domain;
                     cd01208"
                     /db_xref="CDD:269919"
     Site            order(375,453,493)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:269919"
     Site            order(393,442,445..450,501,512,515)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:269919"
     Region          555..640
                     /region_name="PDZ1_APBA1_3-like"
                     /note="PDZ domain 1 of amyloid-beta A4 precursor
                     protein-binding family A member 1 (APBA1), APBA2, APBA3,
                     and related domains; cd06720"
                     /db_xref="CDD:467203"
     Site            order(566..572,586,589,619,623,626..627)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467203"
     Region          644..721
                     /region_name="PDZ2_APBA1_3-like"
                     /note="PDZ domain 2 of amyloid-beta A4 precursor
                     protein-binding family A member 1 (APBA1), APBA2, APBA3,
                     and related domains; cd06793"
                     /db_xref="CDD:467255"
     Site            order(658..664,669,672,701,705,708..709)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467255"
     CDS             1..737
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /coded_by="XM_047432417.1:479..2692"
                     /db_xref="GeneID:321"
                     /db_xref="HGNC:HGNC:579"
                     /db_xref="MIM:602712"
ORIGIN      
        1 mahrklesvg sgmldhrvrp gpvphsqepe sedmelpleg yvpeglelaa lrpespapee
       61 qechnhspdg dsssdyvnnt seeedydegl peeeegityy irycpeddsy legmdcngee
      121 ylahsahpvd tdecqeavee wtdsagphph gheaegsqdy pdgqlpiped epsvleahdq
      181 eedghycask egyqdyypee angntgaspy rlrrgdgdle dqeedidqiv aeikmslsmt
      241 sitsaseasp ehgpepgped sveacppika scspsrhear pkslnllpea khpgdpqrgf
      301 kpktrtpeer lkwpheqvcn gleqprkqqr sdlngpvdnn nipetkkvas fpsfvavpgp
      361 cepedlidgi ifaanylgst qllsernpsk nirmmqaqea vsrvknsegd aqtltevdlf
      421 istqrikvln adtqetmmdh alrtisyiad ignivvlmar rrmprsasqd ciettpgaqe
      481 gkkqykmich vfesedaqli aqsigqafsv ayqeflrang inpedlsqke ysdiintqem
      541 ynddlihfsn senckelqle khkgeilgvv vvesgwgsil ptvilanmmn ggpaarsgkl
      601 sigdqimsin gtslvglpla tcqgiikglk nqtqvklniv scppvttvli krpdlkyqlg
      661 fsvqngiics lmrggiaerg gvrvghriie ingqsvvata hekivqalsn svgeihmktm
      721 paamfrlltg qetplyi
//
LOCUS       XP_047288374             737 aa            linear   PRI 05-AUG-2025
DEFINITION  amyloid-beta A4 precursor protein-binding family A member 2 isoform
            X3 [Homo sapiens].
ACCESSION   XP_047288374
VERSION     XP_047288374.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432418.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..737
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..737
                     /product="amyloid-beta A4 precursor protein-binding family
                     A member 2 isoform X3"
                     /calculated_mol_wt=80999
     Region          363..523
                     /region_name="PTB_X11"
                     /note="X11-like Phosphotyrosine-binding (PTB) domain;
                     cd01208"
                     /db_xref="CDD:269919"
     Site            order(375,453,493)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:269919"
     Site            order(393,442,445..450,501,512,515)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:269919"
     Region          555..640
                     /region_name="PDZ1_APBA1_3-like"
                     /note="PDZ domain 1 of amyloid-beta A4 precursor
                     protein-binding family A member 1 (APBA1), APBA2, APBA3,
                     and related domains; cd06720"
                     /db_xref="CDD:467203"
     Site            order(566..572,586,589,619,623,626..627)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467203"
     Region          644..721
                     /region_name="PDZ2_APBA1_3-like"
                     /note="PDZ domain 2 of amyloid-beta A4 precursor
                     protein-binding family A member 1 (APBA1), APBA2, APBA3,
                     and related domains; cd06793"
                     /db_xref="CDD:467255"
     Site            order(658..664,669,672,701,705,708..709)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467255"
     CDS             1..737
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /coded_by="XM_047432418.1:237..2450"
                     /db_xref="GeneID:321"
                     /db_xref="HGNC:HGNC:579"
                     /db_xref="MIM:602712"
ORIGIN      
        1 mahrklesvg sgmldhrvrp gpvphsqepe sedmelpleg yvpeglelaa lrpespapee
       61 qechnhspdg dsssdyvnnt seeedydegl peeeegityy irycpeddsy legmdcngee
      121 ylahsahpvd tdecqeavee wtdsagphph gheaegsqdy pdgqlpiped epsvleahdq
      181 eedghycask egyqdyypee angntgaspy rlrrgdgdle dqeedidqiv aeikmslsmt
      241 sitsaseasp ehgpepgped sveacppika scspsrhear pkslnllpea khpgdpqrgf
      301 kpktrtpeer lkwpheqvcn gleqprkqqr sdlngpvdnn nipetkkvas fpsfvavpgp
      361 cepedlidgi ifaanylgst qllsernpsk nirmmqaqea vsrvknsegd aqtltevdlf
      421 istqrikvln adtqetmmdh alrtisyiad ignivvlmar rrmprsasqd ciettpgaqe
      481 gkkqykmich vfesedaqli aqsigqafsv ayqeflrang inpedlsqke ysdiintqem
      541 ynddlihfsn senckelqle khkgeilgvv vvesgwgsil ptvilanmmn ggpaarsgkl
      601 sigdqimsin gtslvglpla tcqgiikglk nqtqvklniv scppvttvli krpdlkyqlg
      661 fsvqngiics lmrggiaerg gvrvghriie ingqsvvata hekivqalsn svgeihmktm
      721 paamfrlltg qetplyi
//
LOCUS       XP_047288375             737 aa            linear   PRI 05-AUG-2025
DEFINITION  amyloid-beta A4 precursor protein-binding family A member 2 isoform
            X3 [Homo sapiens].
ACCESSION   XP_047288375
VERSION     XP_047288375.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432419.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..737
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..737
                     /product="amyloid-beta A4 precursor protein-binding family
                     A member 2 isoform X3"
                     /calculated_mol_wt=80999
     Region          363..523
                     /region_name="PTB_X11"
                     /note="X11-like Phosphotyrosine-binding (PTB) domain;
                     cd01208"
                     /db_xref="CDD:269919"
     Site            order(375,453,493)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:269919"
     Site            order(393,442,445..450,501,512,515)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:269919"
     Region          555..640
                     /region_name="PDZ1_APBA1_3-like"
                     /note="PDZ domain 1 of amyloid-beta A4 precursor
                     protein-binding family A member 1 (APBA1), APBA2, APBA3,
                     and related domains; cd06720"
                     /db_xref="CDD:467203"
     Site            order(566..572,586,589,619,623,626..627)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467203"
     Region          644..721
                     /region_name="PDZ2_APBA1_3-like"
                     /note="PDZ domain 2 of amyloid-beta A4 precursor
                     protein-binding family A member 1 (APBA1), APBA2, APBA3,
                     and related domains; cd06793"
                     /db_xref="CDD:467255"
     Site            order(658..664,669,672,701,705,708..709)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467255"
     CDS             1..737
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /coded_by="XM_047432419.1:347..2560"
                     /db_xref="GeneID:321"
                     /db_xref="HGNC:HGNC:579"
                     /db_xref="MIM:602712"
ORIGIN      
        1 mahrklesvg sgmldhrvrp gpvphsqepe sedmelpleg yvpeglelaa lrpespapee
       61 qechnhspdg dsssdyvnnt seeedydegl peeeegityy irycpeddsy legmdcngee
      121 ylahsahpvd tdecqeavee wtdsagphph gheaegsqdy pdgqlpiped epsvleahdq
      181 eedghycask egyqdyypee angntgaspy rlrrgdgdle dqeedidqiv aeikmslsmt
      241 sitsaseasp ehgpepgped sveacppika scspsrhear pkslnllpea khpgdpqrgf
      301 kpktrtpeer lkwpheqvcn gleqprkqqr sdlngpvdnn nipetkkvas fpsfvavpgp
      361 cepedlidgi ifaanylgst qllsernpsk nirmmqaqea vsrvknsegd aqtltevdlf
      421 istqrikvln adtqetmmdh alrtisyiad ignivvlmar rrmprsasqd ciettpgaqe
      481 gkkqykmich vfesedaqli aqsigqafsv ayqeflrang inpedlsqke ysdiintqem
      541 ynddlihfsn senckelqle khkgeilgvv vvesgwgsil ptvilanmmn ggpaarsgkl
      601 sigdqimsin gtslvglpla tcqgiikglk nqtqvklniv scppvttvli krpdlkyqlg
      661 fsvqngiics lmrggiaerg gvrvghriie ingqsvvata hekivqalsn svgeihmktm
      721 paamfrlltg qetplyi
//
LOCUS       XP_047288376             737 aa            linear   PRI 05-AUG-2025
DEFINITION  amyloid-beta A4 precursor protein-binding family A member 2 isoform
            X3 [Homo sapiens].
ACCESSION   XP_047288376
VERSION     XP_047288376.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432420.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..737
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..737
                     /product="amyloid-beta A4 precursor protein-binding family
                     A member 2 isoform X3"
                     /calculated_mol_wt=80999
     Region          363..523
                     /region_name="PTB_X11"
                     /note="X11-like Phosphotyrosine-binding (PTB) domain;
                     cd01208"
                     /db_xref="CDD:269919"
     Site            order(375,453,493)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:269919"
     Site            order(393,442,445..450,501,512,515)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:269919"
     Region          555..640
                     /region_name="PDZ1_APBA1_3-like"
                     /note="PDZ domain 1 of amyloid-beta A4 precursor
                     protein-binding family A member 1 (APBA1), APBA2, APBA3,
                     and related domains; cd06720"
                     /db_xref="CDD:467203"
     Site            order(566..572,586,589,619,623,626..627)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467203"
     Region          644..721
                     /region_name="PDZ2_APBA1_3-like"
                     /note="PDZ domain 2 of amyloid-beta A4 precursor
                     protein-binding family A member 1 (APBA1), APBA2, APBA3,
                     and related domains; cd06793"
                     /db_xref="CDD:467255"
     Site            order(658..664,669,672,701,705,708..709)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467255"
     CDS             1..737
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /coded_by="XM_047432420.1:506..2719"
                     /db_xref="GeneID:321"
                     /db_xref="HGNC:HGNC:579"
                     /db_xref="MIM:602712"
ORIGIN      
        1 mahrklesvg sgmldhrvrp gpvphsqepe sedmelpleg yvpeglelaa lrpespapee
       61 qechnhspdg dsssdyvnnt seeedydegl peeeegityy irycpeddsy legmdcngee
      121 ylahsahpvd tdecqeavee wtdsagphph gheaegsqdy pdgqlpiped epsvleahdq
      181 eedghycask egyqdyypee angntgaspy rlrrgdgdle dqeedidqiv aeikmslsmt
      241 sitsaseasp ehgpepgped sveacppika scspsrhear pkslnllpea khpgdpqrgf
      301 kpktrtpeer lkwpheqvcn gleqprkqqr sdlngpvdnn nipetkkvas fpsfvavpgp
      361 cepedlidgi ifaanylgst qllsernpsk nirmmqaqea vsrvknsegd aqtltevdlf
      421 istqrikvln adtqetmmdh alrtisyiad ignivvlmar rrmprsasqd ciettpgaqe
      481 gkkqykmich vfesedaqli aqsigqafsv ayqeflrang inpedlsqke ysdiintqem
      541 ynddlihfsn senckelqle khkgeilgvv vvesgwgsil ptvilanmmn ggpaarsgkl
      601 sigdqimsin gtslvglpla tcqgiikglk nqtqvklniv scppvttvli krpdlkyqlg
      661 fsvqngiics lmrggiaerg gvrvghriie ingqsvvata hekivqalsn svgeihmktm
      721 paamfrlltg qetplyi
//
LOCUS       XP_047288377             737 aa            linear   PRI 05-AUG-2025
DEFINITION  amyloid-beta A4 precursor protein-binding family A member 2 isoform
            X3 [Homo sapiens].
ACCESSION   XP_047288377
VERSION     XP_047288377.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432421.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..737
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..737
                     /product="amyloid-beta A4 precursor protein-binding family
                     A member 2 isoform X3"
                     /calculated_mol_wt=80999
     Region          363..523
                     /region_name="PTB_X11"
                     /note="X11-like Phosphotyrosine-binding (PTB) domain;
                     cd01208"
                     /db_xref="CDD:269919"
     Site            order(375,453,493)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:269919"
     Site            order(393,442,445..450,501,512,515)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:269919"
     Region          555..640
                     /region_name="PDZ1_APBA1_3-like"
                     /note="PDZ domain 1 of amyloid-beta A4 precursor
                     protein-binding family A member 1 (APBA1), APBA2, APBA3,
                     and related domains; cd06720"
                     /db_xref="CDD:467203"
     Site            order(566..572,586,589,619,623,626..627)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467203"
     Region          644..721
                     /region_name="PDZ2_APBA1_3-like"
                     /note="PDZ domain 2 of amyloid-beta A4 precursor
                     protein-binding family A member 1 (APBA1), APBA2, APBA3,
                     and related domains; cd06793"
                     /db_xref="CDD:467255"
     Site            order(658..664,669,672,701,705,708..709)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467255"
     CDS             1..737
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /coded_by="XM_047432421.1:264..2477"
                     /db_xref="GeneID:321"
                     /db_xref="HGNC:HGNC:579"
                     /db_xref="MIM:602712"
ORIGIN      
        1 mahrklesvg sgmldhrvrp gpvphsqepe sedmelpleg yvpeglelaa lrpespapee
       61 qechnhspdg dsssdyvnnt seeedydegl peeeegityy irycpeddsy legmdcngee
      121 ylahsahpvd tdecqeavee wtdsagphph gheaegsqdy pdgqlpiped epsvleahdq
      181 eedghycask egyqdyypee angntgaspy rlrrgdgdle dqeedidqiv aeikmslsmt
      241 sitsaseasp ehgpepgped sveacppika scspsrhear pkslnllpea khpgdpqrgf
      301 kpktrtpeer lkwpheqvcn gleqprkqqr sdlngpvdnn nipetkkvas fpsfvavpgp
      361 cepedlidgi ifaanylgst qllsernpsk nirmmqaqea vsrvknsegd aqtltevdlf
      421 istqrikvln adtqetmmdh alrtisyiad ignivvlmar rrmprsasqd ciettpgaqe
      481 gkkqykmich vfesedaqli aqsigqafsv ayqeflrang inpedlsqke ysdiintqem
      541 ynddlihfsn senckelqle khkgeilgvv vvesgwgsil ptvilanmmn ggpaarsgkl
      601 sigdqimsin gtslvglpla tcqgiikglk nqtqvklniv scppvttvli krpdlkyqlg
      661 fsvqngiics lmrggiaerg gvrvghriie ingqsvvata hekivqalsn svgeihmktm
      721 paamfrlltg qetplyi
//
LOCUS       XP_047288378             737 aa            linear   PRI 05-AUG-2025
DEFINITION  amyloid-beta A4 precursor protein-binding family A member 2 isoform
            X3 [Homo sapiens].
ACCESSION   XP_047288378
VERSION     XP_047288378.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432422.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..737
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..737
                     /product="amyloid-beta A4 precursor protein-binding family
                     A member 2 isoform X3"
                     /calculated_mol_wt=80999
     Region          363..523
                     /region_name="PTB_X11"
                     /note="X11-like Phosphotyrosine-binding (PTB) domain;
                     cd01208"
                     /db_xref="CDD:269919"
     Site            order(375,453,493)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:269919"
     Site            order(393,442,445..450,501,512,515)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:269919"
     Region          555..640
                     /region_name="PDZ1_APBA1_3-like"
                     /note="PDZ domain 1 of amyloid-beta A4 precursor
                     protein-binding family A member 1 (APBA1), APBA2, APBA3,
                     and related domains; cd06720"
                     /db_xref="CDD:467203"
     Site            order(566..572,586,589,619,623,626..627)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467203"
     Region          644..721
                     /region_name="PDZ2_APBA1_3-like"
                     /note="PDZ domain 2 of amyloid-beta A4 precursor
                     protein-binding family A member 1 (APBA1), APBA2, APBA3,
                     and related domains; cd06793"
                     /db_xref="CDD:467255"
     Site            order(658..664,669,672,701,705,708..709)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467255"
     CDS             1..737
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /coded_by="XM_047432422.1:233..2446"
                     /db_xref="GeneID:321"
                     /db_xref="HGNC:HGNC:579"
                     /db_xref="MIM:602712"
ORIGIN      
        1 mahrklesvg sgmldhrvrp gpvphsqepe sedmelpleg yvpeglelaa lrpespapee
       61 qechnhspdg dsssdyvnnt seeedydegl peeeegityy irycpeddsy legmdcngee
      121 ylahsahpvd tdecqeavee wtdsagphph gheaegsqdy pdgqlpiped epsvleahdq
      181 eedghycask egyqdyypee angntgaspy rlrrgdgdle dqeedidqiv aeikmslsmt
      241 sitsaseasp ehgpepgped sveacppika scspsrhear pkslnllpea khpgdpqrgf
      301 kpktrtpeer lkwpheqvcn gleqprkqqr sdlngpvdnn nipetkkvas fpsfvavpgp
      361 cepedlidgi ifaanylgst qllsernpsk nirmmqaqea vsrvknsegd aqtltevdlf
      421 istqrikvln adtqetmmdh alrtisyiad ignivvlmar rrmprsasqd ciettpgaqe
      481 gkkqykmich vfesedaqli aqsigqafsv ayqeflrang inpedlsqke ysdiintqem
      541 ynddlihfsn senckelqle khkgeilgvv vvesgwgsil ptvilanmmn ggpaarsgkl
      601 sigdqimsin gtslvglpla tcqgiikglk nqtqvklniv scppvttvli krpdlkyqlg
      661 fsvqngiics lmrggiaerg gvrvghriie ingqsvvata hekivqalsn svgeihmktm
      721 paamfrlltg qetplyi
//
LOCUS       XP_047288379             737 aa            linear   PRI 05-AUG-2025
DEFINITION  amyloid-beta A4 precursor protein-binding family A member 2 isoform
            X3 [Homo sapiens].
ACCESSION   XP_047288379
VERSION     XP_047288379.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432423.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..737
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..737
                     /product="amyloid-beta A4 precursor protein-binding family
                     A member 2 isoform X3"
                     /calculated_mol_wt=80999
     Region          363..523
                     /region_name="PTB_X11"
                     /note="X11-like Phosphotyrosine-binding (PTB) domain;
                     cd01208"
                     /db_xref="CDD:269919"
     Site            order(375,453,493)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:269919"
     Site            order(393,442,445..450,501,512,515)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:269919"
     Region          555..640
                     /region_name="PDZ1_APBA1_3-like"
                     /note="PDZ domain 1 of amyloid-beta A4 precursor
                     protein-binding family A member 1 (APBA1), APBA2, APBA3,
                     and related domains; cd06720"
                     /db_xref="CDD:467203"
     Site            order(566..572,586,589,619,623,626..627)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467203"
     Region          644..721
                     /region_name="PDZ2_APBA1_3-like"
                     /note="PDZ domain 2 of amyloid-beta A4 precursor
                     protein-binding family A member 1 (APBA1), APBA2, APBA3,
                     and related domains; cd06793"
                     /db_xref="CDD:467255"
     Site            order(658..664,669,672,701,705,708..709)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467255"
     CDS             1..737
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /coded_by="XM_047432423.1:474..2687"
                     /db_xref="GeneID:321"
                     /db_xref="HGNC:HGNC:579"
                     /db_xref="MIM:602712"
ORIGIN      
        1 mahrklesvg sgmldhrvrp gpvphsqepe sedmelpleg yvpeglelaa lrpespapee
       61 qechnhspdg dsssdyvnnt seeedydegl peeeegityy irycpeddsy legmdcngee
      121 ylahsahpvd tdecqeavee wtdsagphph gheaegsqdy pdgqlpiped epsvleahdq
      181 eedghycask egyqdyypee angntgaspy rlrrgdgdle dqeedidqiv aeikmslsmt
      241 sitsaseasp ehgpepgped sveacppika scspsrhear pkslnllpea khpgdpqrgf
      301 kpktrtpeer lkwpheqvcn gleqprkqqr sdlngpvdnn nipetkkvas fpsfvavpgp
      361 cepedlidgi ifaanylgst qllsernpsk nirmmqaqea vsrvknsegd aqtltevdlf
      421 istqrikvln adtqetmmdh alrtisyiad ignivvlmar rrmprsasqd ciettpgaqe
      481 gkkqykmich vfesedaqli aqsigqafsv ayqeflrang inpedlsqke ysdiintqem
      541 ynddlihfsn senckelqle khkgeilgvv vvesgwgsil ptvilanmmn ggpaarsgkl
      601 sigdqimsin gtslvglpla tcqgiikglk nqtqvklniv scppvttvli krpdlkyqlg
      661 fsvqngiics lmrggiaerg gvrvghriie ingqsvvata hekivqalsn svgeihmktm
      721 paamfrlltg qetplyi
//
LOCUS       XP_047288380             737 aa            linear   PRI 05-AUG-2025
DEFINITION  amyloid-beta A4 precursor protein-binding family A member 2 isoform
            X3 [Homo sapiens].
ACCESSION   XP_047288380
VERSION     XP_047288380.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432424.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..737
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..737
                     /product="amyloid-beta A4 precursor protein-binding family
                     A member 2 isoform X3"
                     /calculated_mol_wt=80999
     Region          363..523
                     /region_name="PTB_X11"
                     /note="X11-like Phosphotyrosine-binding (PTB) domain;
                     cd01208"
                     /db_xref="CDD:269919"
     Site            order(375,453,493)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:269919"
     Site            order(393,442,445..450,501,512,515)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:269919"
     Region          555..640
                     /region_name="PDZ1_APBA1_3-like"
                     /note="PDZ domain 1 of amyloid-beta A4 precursor
                     protein-binding family A member 1 (APBA1), APBA2, APBA3,
                     and related domains; cd06720"
                     /db_xref="CDD:467203"
     Site            order(566..572,586,589,619,623,626..627)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467203"
     Region          644..721
                     /region_name="PDZ2_APBA1_3-like"
                     /note="PDZ domain 2 of amyloid-beta A4 precursor
                     protein-binding family A member 1 (APBA1), APBA2, APBA3,
                     and related domains; cd06793"
                     /db_xref="CDD:467255"
     Site            order(658..664,669,672,701,705,708..709)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467255"
     CDS             1..737
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /coded_by="XM_047432424.1:656..2869"
                     /db_xref="GeneID:321"
                     /db_xref="HGNC:HGNC:579"
                     /db_xref="MIM:602712"
ORIGIN      
        1 mahrklesvg sgmldhrvrp gpvphsqepe sedmelpleg yvpeglelaa lrpespapee
       61 qechnhspdg dsssdyvnnt seeedydegl peeeegityy irycpeddsy legmdcngee
      121 ylahsahpvd tdecqeavee wtdsagphph gheaegsqdy pdgqlpiped epsvleahdq
      181 eedghycask egyqdyypee angntgaspy rlrrgdgdle dqeedidqiv aeikmslsmt
      241 sitsaseasp ehgpepgped sveacppika scspsrhear pkslnllpea khpgdpqrgf
      301 kpktrtpeer lkwpheqvcn gleqprkqqr sdlngpvdnn nipetkkvas fpsfvavpgp
      361 cepedlidgi ifaanylgst qllsernpsk nirmmqaqea vsrvknsegd aqtltevdlf
      421 istqrikvln adtqetmmdh alrtisyiad ignivvlmar rrmprsasqd ciettpgaqe
      481 gkkqykmich vfesedaqli aqsigqafsv ayqeflrang inpedlsqke ysdiintqem
      541 ynddlihfsn senckelqle khkgeilgvv vvesgwgsil ptvilanmmn ggpaarsgkl
      601 sigdqimsin gtslvglpla tcqgiikglk nqtqvklniv scppvttvli krpdlkyqlg
      661 fsvqngiics lmrggiaerg gvrvghriie ingqsvvata hekivqalsn svgeihmktm
      721 paamfrlltg qetplyi
//
LOCUS       XP_047288381             737 aa            linear   PRI 05-AUG-2025
DEFINITION  amyloid-beta A4 precursor protein-binding family A member 2 isoform
            X3 [Homo sapiens].
ACCESSION   XP_047288381
VERSION     XP_047288381.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432425.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..737
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..737
                     /product="amyloid-beta A4 precursor protein-binding family
                     A member 2 isoform X3"
                     /calculated_mol_wt=80999
     Region          363..523
                     /region_name="PTB_X11"
                     /note="X11-like Phosphotyrosine-binding (PTB) domain;
                     cd01208"
                     /db_xref="CDD:269919"
     Site            order(375,453,493)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:269919"
     Site            order(393,442,445..450,501,512,515)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:269919"
     Region          555..640
                     /region_name="PDZ1_APBA1_3-like"
                     /note="PDZ domain 1 of amyloid-beta A4 precursor
                     protein-binding family A member 1 (APBA1), APBA2, APBA3,
                     and related domains; cd06720"
                     /db_xref="CDD:467203"
     Site            order(566..572,586,589,619,623,626..627)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467203"
     Region          644..721
                     /region_name="PDZ2_APBA1_3-like"
                     /note="PDZ domain 2 of amyloid-beta A4 precursor
                     protein-binding family A member 1 (APBA1), APBA2, APBA3,
                     and related domains; cd06793"
                     /db_xref="CDD:467255"
     Site            order(658..664,669,672,701,705,708..709)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467255"
     CDS             1..737
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /coded_by="XM_047432425.1:669..2882"
                     /db_xref="GeneID:321"
                     /db_xref="HGNC:HGNC:579"
                     /db_xref="MIM:602712"
ORIGIN      
        1 mahrklesvg sgmldhrvrp gpvphsqepe sedmelpleg yvpeglelaa lrpespapee
       61 qechnhspdg dsssdyvnnt seeedydegl peeeegityy irycpeddsy legmdcngee
      121 ylahsahpvd tdecqeavee wtdsagphph gheaegsqdy pdgqlpiped epsvleahdq
      181 eedghycask egyqdyypee angntgaspy rlrrgdgdle dqeedidqiv aeikmslsmt
      241 sitsaseasp ehgpepgped sveacppika scspsrhear pkslnllpea khpgdpqrgf
      301 kpktrtpeer lkwpheqvcn gleqprkqqr sdlngpvdnn nipetkkvas fpsfvavpgp
      361 cepedlidgi ifaanylgst qllsernpsk nirmmqaqea vsrvknsegd aqtltevdlf
      421 istqrikvln adtqetmmdh alrtisyiad ignivvlmar rrmprsasqd ciettpgaqe
      481 gkkqykmich vfesedaqli aqsigqafsv ayqeflrang inpedlsqke ysdiintqem
      541 ynddlihfsn senckelqle khkgeilgvv vvesgwgsil ptvilanmmn ggpaarsgkl
      601 sigdqimsin gtslvglpla tcqgiikglk nqtqvklniv scppvttvli krpdlkyqlg
      661 fsvqngiics lmrggiaerg gvrvghriie ingqsvvata hekivqalsn svgeihmktm
      721 paamfrlltg qetplyi
//
LOCUS       XP_047288382             690 aa            linear   PRI 05-AUG-2025
DEFINITION  amyloid-beta A4 precursor protein-binding family A member 2 isoform
            X4 [Homo sapiens].
ACCESSION   XP_047288382
VERSION     XP_047288382.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432426.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..690
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..690
                     /product="amyloid-beta A4 precursor protein-binding family
                     A member 2 isoform X4"
                     /calculated_mol_wt=76039
     Region          363..523
                     /region_name="PTB_X11"
                     /note="X11-like Phosphotyrosine-binding (PTB) domain;
                     cd01208"
                     /db_xref="CDD:269919"
     Site            order(375,453,493)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:269919"
     Site            order(393,442,445..450,501,512,515)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:269919"
     Region          555..640
                     /region_name="PDZ1_APBA1_3-like"
                     /note="PDZ domain 1 of amyloid-beta A4 precursor
                     protein-binding family A member 1 (APBA1), APBA2, APBA3,
                     and related domains; cd06720"
                     /db_xref="CDD:467203"
     Site            order(566..572,586,589,619,623,626..627)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467203"
     Region          644..>667
                     /region_name="PDZ_canonical"
                     /note="canonical PDZ domain; cl49608"
                     /db_xref="CDD:483948"
     CDS             1..690
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /coded_by="XM_047432426.1:510..2582"
                     /db_xref="GeneID:321"
                     /db_xref="HGNC:HGNC:579"
                     /db_xref="MIM:602712"
ORIGIN      
        1 mahrklesvg sgmldhrvrp gpvphsqepe sedmelpleg yvpeglelaa lrpespapee
       61 qechnhspdg dsssdyvnnt seeedydegl peeeegityy irycpeddsy legmdcngee
      121 ylahsahpvd tdecqeavee wtdsagphph gheaegsqdy pdgqlpiped epsvleahdq
      181 eedghycask egyqdyypee angntgaspy rlrrgdgdle dqeedidqiv aeikmslsmt
      241 sitsaseasp ehgpepgped sveacppika scspsrhear pkslnllpea khpgdpqrgf
      301 kpktrtpeer lkwpheqvcn gleqprkqqr sdlngpvdnn nipetkkvas fpsfvavpgp
      361 cepedlidgi ifaanylgst qllsernpsk nirmmqaqea vsrvknsegd aqtltevdlf
      421 istqrikvln adtqetmmdh alrtisyiad ignivvlmar rrmprsasqd ciettpgaqe
      481 gkkqykmich vfesedaqli aqsigqafsv ayqeflrang inpedlsqke ysdiintqem
      541 ynddlihfsn senckelqle khkgeilgvv vvesgwgsil ptvilanmmn ggpaarsgkl
      601 sigdqimsin gtslvglpla tcqgiikglk nqtqvklniv scppvttvli krpdlkyqlg
      661 fsvqngitqr aemwplsgvk kkragntqiv
//
LOCUS       XP_047288383             394 aa            linear   PRI 05-AUG-2025
DEFINITION  amyloid-beta A4 precursor protein-binding family A member 2 isoform
            X5 [Homo sapiens].
ACCESSION   XP_047288383
VERSION     XP_047288383.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432427.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..394
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..394
                     /product="amyloid-beta A4 precursor protein-binding family
                     A member 2 isoform X5"
                     /calculated_mol_wt=43117
     Region          67..227
                     /region_name="PTB_X11"
                     /note="X11-like Phosphotyrosine-binding (PTB) domain;
                     cd01208"
                     /db_xref="CDD:269919"
     Site            order(79,157,197)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:269919"
     Site            order(97,146,149..154,205,216,219)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:269919"
     Region          259..344
                     /region_name="PDZ1_APBA1_3-like"
                     /note="PDZ domain 1 of amyloid-beta A4 precursor
                     protein-binding family A member 1 (APBA1), APBA2, APBA3,
                     and related domains; cd06720"
                     /db_xref="CDD:467203"
     Site            order(270..276,290,293,323,327,330..331)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467203"
     Region          348..>371
                     /region_name="PDZ_canonical"
                     /note="canonical PDZ domain; cl49608"
                     /db_xref="CDD:483948"
     CDS             1..394
                     /gene="APBA2"
                     /gene_synonym="D15S1518E; HsT16821; LIN-10; MGC:14091;
                     MINT2; X11-BETA; X11L"
                     /coded_by="XM_047432427.1:380..1564"
                     /db_xref="GeneID:321"
                     /db_xref="HGNC:HGNC:579"
                     /db_xref="MIM:602712"
ORIGIN      
        1 mavipesawk hpdyvddgls gvcngleqpr kqqrsdlngp vdnnnipetk kvasfpsfva
       61 vpgpcepedl idgiifaany lgstqllser npsknirmmq aqeavsrvkn segdaqtlte
      121 vdlfistqri kvlnadtqet mmdhalrtis yiadignivv lmarrrmprs asqdciettp
      181 gaqegkkqyk michvfesed aqliaqsigq afsvayqefl ranginpedl sqkeysdiin
      241 tqemynddli hfsnsencke lqlekhkgei lgvvvvesgw gsilptvila nmmnggpaar
      301 sgklsigdqi msingtslvg lplatcqgii kglknqtqvk lnivscppvt tvlikrpdlk
      361 yqlgfsvqng itqraemwpl sgvkkkragn tqiv
//
LOCUS       XP_011519799             234 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 202 isoform X1 [Homo sapiens].
ACCESSION   XP_011519799
VERSION     XP_011519799.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521497.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..234
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..234
                     /product="transmembrane protein 202 isoform X1"
                     /calculated_mol_wt=26686
     CDS             1..234
                     /gene="TMEM202"
                     /coded_by="XM_011521497.3:148..852"
                     /db_xref="GeneID:338949"
                     /db_xref="HGNC:HGNC:33733"
ORIGIN      
        1 mscqrqqqlm dqahiyirtl cgslcsfsll mliamsplnw vqflvikngl elyaglwtlc
       61 nhelcwshtp kppyylqysr afflisvfti ltglgwlfss wilnrgsmtt nldlkvsmls
      121 fisatclllc lnlfvaqvhw htrdamesdl lwtyylnwcs difymfagii sllnyltsrs
      181 pacdenvtvi ptersrlgvg pvttvspakd egprsemesl svreknlpks glww
//
LOCUS       XP_024305678             229 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 202 isoform X2 [Homo sapiens].
ACCESSION   XP_024305678
VERSION     XP_024305678.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449910.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..229
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..229
                     /product="transmembrane protein 202 isoform X2"
                     /calculated_mol_wt=25920
     CDS             1..229
                     /gene="TMEM202"
                     /coded_by="XM_024449910.2:23..712"
                     /db_xref="GeneID:338949"
                     /db_xref="HGNC:HGNC:33733"
ORIGIN      
        1 merrehltlt fhspevpkik gnrkyqrptv pakkhpsasm scqrqqqlmd qahiyirtlc
       61 gslcsfsllm liamsplnwv qflvikngle lyaglwtlcn helcwshtpk ppyylqysra
      121 fflisvftil tglgwlfssw ilnrgsmttn ldlkvsmlsf isgiisllny ltsrspacde
      181 nvtvipters rlgvgpvttv spakdegprs emeslsvrek nlpksglww
//
LOCUS       XP_011519801             162 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 202 isoform X3 [Homo sapiens].
ACCESSION   XP_011519801
VERSION     XP_011519801.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521499.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..162
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..162
                     /product="transmembrane protein 202 isoform X3"
                     /calculated_mol_wt=18364
     CDS             1..162
                     /gene="TMEM202"
                     /coded_by="XM_011521499.3:170..658"
                     /db_xref="GeneID:338949"
                     /db_xref="HGNC:HGNC:33733"
ORIGIN      
        1 mdylqysraf flisvftilt glgwlfsswi lnrgsmttnl dlkvsmlsfi satclllcln
       61 lfvaqvhwht rdamesdllw tyylnwcsdi fymfagiisl lnyltsrspa cdenvtvipt
      121 ersrlgvgpv ttvspakdeg prsemeslsv reknlpksgl ww
//
LOCUS       XP_047288384             316 aa            linear   PRI 05-AUG-2025
DEFINITION  isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial isoform
            X1 [Homo sapiens].
ACCESSION   XP_047288384
VERSION     XP_047288384.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432428.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..316
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..316
                     /product="isocitrate dehydrogenase [NAD] subunit alpha,
                     mitochondrial isoform X1"
                     /calculated_mol_wt=34375
     Region          1..312
                     /region_name="Iso_dh"
                     /note="Isocitrate/isopropylmalate dehydrogenase; cl00445"
                     /db_xref="CDD:444908"
     CDS             1..316
                     /gene="IDH3A"
                     /gene_synonym="RP90"
                     /coded_by="XM_047432428.1:705..1655"
                     /db_xref="GeneID:3419"
                     /db_xref="HGNC:HGNC:5384"
                     /db_xref="MIM:601149"
ORIGIN      
        1 mkifdaakap iqweernvta iqgpggkwmi pseakesmdk nkmglkgplk tpiaaghpsm
       61 nlllrktfdl yanvrpcvsi egyktpytdv nivtirente geysgiehvi vdgvvqsikl
      121 itegaskria efafeyarnn hrsnvtavhk animrmsdgl flqkcrevae sckdikfnem
      181 yldtvclnmv qdpsqfdvlv mpnlygdils dlcagliggl gvtpsgniga ngvaifesvh
      241 gtapdiagkd manptallls avmmlrhmgl fdhaarieaa cfatikdgks ltkdlggnak
      301 csdfteeicr rvkdld
//
LOCUS       XP_024305679             316 aa            linear   PRI 05-AUG-2025
DEFINITION  isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial isoform
            X1 [Homo sapiens].
ACCESSION   XP_024305679
VERSION     XP_024305679.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449911.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..316
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..316
                     /product="isocitrate dehydrogenase [NAD] subunit alpha,
                     mitochondrial isoform X1"
                     /calculated_mol_wt=34375
     Region          1..312
                     /region_name="Iso_dh"
                     /note="Isocitrate/isopropylmalate dehydrogenase; cl00445"
                     /db_xref="CDD:444908"
     CDS             1..316
                     /gene="IDH3A"
                     /gene_synonym="RP90"
                     /coded_by="XM_024449911.2:448..1398"
                     /db_xref="GeneID:3419"
                     /db_xref="HGNC:HGNC:5384"
                     /db_xref="MIM:601149"
ORIGIN      
        1 mkifdaakap iqweernvta iqgpggkwmi pseakesmdk nkmglkgplk tpiaaghpsm
       61 nlllrktfdl yanvrpcvsi egyktpytdv nivtirente geysgiehvi vdgvvqsikl
      121 itegaskria efafeyarnn hrsnvtavhk animrmsdgl flqkcrevae sckdikfnem
      181 yldtvclnmv qdpsqfdvlv mpnlygdils dlcagliggl gvtpsgniga ngvaifesvh
      241 gtapdiagkd manptallls avmmlrhmgl fdhaarieaa cfatikdgks ltkdlggnak
      301 csdfteeicr rvkdld
//
LOCUS       XP_047288385             316 aa            linear   PRI 05-AUG-2025
DEFINITION  isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial isoform
            X1 [Homo sapiens].
ACCESSION   XP_047288385
VERSION     XP_047288385.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432429.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..316
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..316
                     /product="isocitrate dehydrogenase [NAD] subunit alpha,
                     mitochondrial isoform X1"
                     /calculated_mol_wt=34375
     Region          1..312
                     /region_name="Iso_dh"
                     /note="Isocitrate/isopropylmalate dehydrogenase; cl00445"
                     /db_xref="CDD:444908"
     CDS             1..316
                     /gene="IDH3A"
                     /gene_synonym="RP90"
                     /coded_by="XM_047432429.1:960..1910"
                     /db_xref="GeneID:3419"
                     /db_xref="HGNC:HGNC:5384"
                     /db_xref="MIM:601149"
ORIGIN      
        1 mkifdaakap iqweernvta iqgpggkwmi pseakesmdk nkmglkgplk tpiaaghpsm
       61 nlllrktfdl yanvrpcvsi egyktpytdv nivtirente geysgiehvi vdgvvqsikl
      121 itegaskria efafeyarnn hrsnvtavhk animrmsdgl flqkcrevae sckdikfnem
      181 yldtvclnmv qdpsqfdvlv mpnlygdils dlcagliggl gvtpsgniga ngvaifesvh
      241 gtapdiagkd manptallls avmmlrhmgl fdhaarieaa cfatikdgks ltkdlggnak
      301 csdfteeicr rvkdld
//
LOCUS       XP_047288386             257 aa            linear   PRI 05-AUG-2025
DEFINITION  isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial isoform
            X2 [Homo sapiens].
ACCESSION   XP_047288386
VERSION     XP_047288386.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432430.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..257
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..257
                     /product="isocitrate dehydrogenase [NAD] subunit alpha,
                     mitochondrial isoform X2"
                     /calculated_mol_wt=28003
     Region          <1..253
                     /region_name="Iso_dh"
                     /note="Isocitrate/isopropylmalate dehydrogenase; cl00445"
                     /db_xref="CDD:444908"
     CDS             1..257
                     /gene="IDH3A"
                     /gene_synonym="RP90"
                     /coded_by="XM_047432430.1:767..1540"
                     /db_xref="GeneID:3419"
                     /db_xref="HGNC:HGNC:5384"
                     /db_xref="MIM:601149"
ORIGIN      
        1 mnlllrktfd lyanvrpcvs iegyktpytd vnivtirent egeysgiehv ivdgvvqsik
       61 litegaskri aefafeyarn nhrsnvtavh kanimrmsdg lflqkcreva esckdikfne
      121 myldtvclnm vqdpsqfdvl vmpnlygdil sdlcagligg lgvtpsgnig angvaifesv
      181 hgtapdiagk dmanptalll savmmlrhmg lfdhaariea acfatikdgk sltkdlggna
      241 kcsdfteeic rrvkdld
//
LOCUS       XP_016877610             545 aa            linear   PRI 05-AUG-2025
DEFINITION  gliomedin isoform X1 [Homo sapiens].
ACCESSION   XP_016877610
VERSION     XP_016877610.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022121.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..545
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..545
                     /product="gliomedin isoform X1"
                     /calculated_mol_wt=58334
     Region          <151..>285
                     /region_name="gly_rich_SclB"
                     /note="LPXTG-anchored collagen-like adhesin Scl2/SclB;
                     NF038329"
                     /db_xref="CDD:468478"
     Region          151..206
                     /region_name="Collagen"
                     /note="Collagen triple helix repeat (20 copies);
                     pfam01391"
                     /db_xref="CDD:460189"
     Region          298..538
                     /region_name="OLF"
                     /note="Olfactomedin-like domain; pfam02191"
                     /db_xref="CDD:460482"
     CDS             1..545
                     /gene="GLDN"
                     /gene_synonym="CLOM; COLM; CRG-L2; CRGL2; LCCS11; UNC-112;
                     UNC-122"
                     /coded_by="XM_017022121.2:31..1668"
                     /db_xref="GeneID:342035"
                     /db_xref="HGNC:HGNC:29514"
                     /db_xref="MIM:608603"
ORIGIN      
        1 margaeggrg dagwglrgal aavallsaln aagtvfalcq wrglssalra leaqrgreqr
       61 edsalrsfla elsraprgas appqdpassa rnkrshsgep aphiraeshd mlmmmtysmv
      121 pirvmvdlcn stkgicltgp pgagglpghn gldgqpgpqg pkgekgangk rgkmgipgaa
      181 gnpgergekg dhgelglqgn egppgqkgek gdkgdvsndv llagakgdqg ppgppgppgp
      241 pgppgppgsr rakgprqpsm fngqcpgetc aipnddtlvg kadekasehh spqaesmits
      301 ignpvqvlkv tetfgtwire sanksddriw vtehfsgimv kefkdqpsll ngsytfihlp
      361 yyfhgcghvv ynnslyyhkg gsntlvrfef gqetsqtlkl enalyfdrky lfansktyfn
      421 lavdekglwi iyassvdgss ilvaqldert fsvvqhvntt ypkskagnaf iargilyvtd
      481 tkdmrvtfaf dllggkqina nfdlrtsqsv lamlaynmrd qhlyswedgh lmlypvqfls
      541 ttlnq
//
LOCUS       XP_011519803             431 aa            linear   PRI 05-AUG-2025
DEFINITION  gliomedin isoform X2 [Homo sapiens].
ACCESSION   XP_011519803
VERSION     XP_011519803.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521501.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..431
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..431
                     /product="gliomedin isoform X2"
                     /calculated_mol_wt=46191
     Region          <37..>171
                     /region_name="gly_rich_SclB"
                     /note="LPXTG-anchored collagen-like adhesin Scl2/SclB;
                     NF038329"
                     /db_xref="CDD:468478"
     Region          37..92
                     /region_name="Collagen"
                     /note="Collagen triple helix repeat (20 copies);
                     pfam01391"
                     /db_xref="CDD:460189"
     Region          184..424
                     /region_name="OLF"
                     /note="Olfactomedin-like domain; pfam02191"
                     /db_xref="CDD:460482"
     CDS             1..431
                     /gene="GLDN"
                     /gene_synonym="CLOM; COLM; CRG-L2; CRGL2; LCCS11; UNC-112;
                     UNC-122"
                     /coded_by="XM_011521501.3:6656..7951"
                     /db_xref="GeneID:342035"
                     /db_xref="HGNC:HGNC:29514"
                     /db_xref="MIM:608603"
ORIGIN      
        1 mirvmvdlcn stkgicltgp sgppgppgag glpghngldg qpgpqgpkge kgangkrgkm
       61 gipgaagnpg ergekgdhge lglqgnegpp gqkgekgdkg dvsndvllag akgdqgppgp
      121 pgppgppgpp gppgsrrakg prqpsmfngq cpgetcaipn ddtlvgkade kasehhspqa
      181 esmitsignp vqvlkvtetf gtwiresank sddriwvteh fsgimvkefk dqpsllngsy
      241 tfihlpyyfh gcghvvynns lyyhkggsnt lvrfefgqet sqtlklenal yfdrkylfan
      301 sktyfnlavd ekglwiiyas svdgssilva qldertfsvv qhvnttypks kagnafiarg
      361 ilyvtdtkdm rvtfafdllg gkqinanfdl rtsqsvlaml aynmrdqhly swedghlmly
      421 pvqflsttln q
//
LOCUS       XP_016877611             427 aa            linear   PRI 05-AUG-2025
DEFINITION  gliomedin isoform X3 [Homo sapiens].
ACCESSION   XP_016877611
VERSION     XP_016877611.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022122.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..427
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..427
                     /product="gliomedin isoform X3"
                     /calculated_mol_wt=45691
     Region          <33..>167
                     /region_name="gly_rich_SclB"
                     /note="LPXTG-anchored collagen-like adhesin Scl2/SclB;
                     NF038329"
                     /db_xref="CDD:468478"
     Region          33..88
                     /region_name="Collagen"
                     /note="Collagen triple helix repeat (20 copies);
                     pfam01391"
                     /db_xref="CDD:460189"
     Region          180..420
                     /region_name="OLF"
                     /note="Olfactomedin-like domain; pfam02191"
                     /db_xref="CDD:460482"
     CDS             1..427
                     /gene="GLDN"
                     /gene_synonym="CLOM; COLM; CRG-L2; CRGL2; LCCS11; UNC-112;
                     UNC-122"
                     /coded_by="XM_017022122.3:307..1590"
                     /db_xref="GeneID:342035"
                     /db_xref="HGNC:HGNC:29514"
                     /db_xref="MIM:608603"
ORIGIN      
        1 mvdlcnstkg icltgpsgpp gppgagglpg hngldgqpgp qgpkgekgan gkrgkmgipg
       61 aagnpgerge kgdhgelglq gnegppgqkg ekgdkgdvsn dvllagakgd qgppgppgpp
      121 gppgppgppg srrakgprqp smfngqcpge tcaipnddtl vgkadekase hhspqaesmi
      181 tsignpvqvl kvtetfgtwi resanksddr iwvtehfsgi mvkefkdqps llngsytfih
      241 lpyyfhgcgh vvynnslyyh kggsntlvrf efgqetsqtl klenalyfdr kylfanskty
      301 fnlavdekgl wiiyassvdg ssilvaqlde rtfsvvqhvn ttypkskagn afiargilyv
      361 tdtkdmrvtf afdllggkqi nanfdlrtsq svlamlaynm rdqhlyswed ghlmlypvqf
      421 lsttlnq
//
LOCUS       XP_016877613             427 aa            linear   PRI 05-AUG-2025
DEFINITION  gliomedin isoform X3 [Homo sapiens].
ACCESSION   XP_016877613
VERSION     XP_016877613.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022124.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..427
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..427
                     /product="gliomedin isoform X3"
                     /calculated_mol_wt=45691
     Region          <33..>167
                     /region_name="gly_rich_SclB"
                     /note="LPXTG-anchored collagen-like adhesin Scl2/SclB;
                     NF038329"
                     /db_xref="CDD:468478"
     Region          33..88
                     /region_name="Collagen"
                     /note="Collagen triple helix repeat (20 copies);
                     pfam01391"
                     /db_xref="CDD:460189"
     Region          180..420
                     /region_name="OLF"
                     /note="Olfactomedin-like domain; pfam02191"
                     /db_xref="CDD:460482"
     CDS             1..427
                     /gene="GLDN"
                     /gene_synonym="CLOM; COLM; CRG-L2; CRGL2; LCCS11; UNC-112;
                     UNC-122"
                     /coded_by="XM_017022124.3:29..1312"
                     /db_xref="GeneID:342035"
                     /db_xref="HGNC:HGNC:29514"
                     /db_xref="MIM:608603"
ORIGIN      
        1 mvdlcnstkg icltgpsgpp gppgagglpg hngldgqpgp qgpkgekgan gkrgkmgipg
       61 aagnpgerge kgdhgelglq gnegppgqkg ekgdkgdvsn dvllagakgd qgppgppgpp
      121 gppgppgppg srrakgprqp smfngqcpge tcaipnddtl vgkadekase hhspqaesmi
      181 tsignpvqvl kvtetfgtwi resanksddr iwvtehfsgi mvkefkdqps llngsytfih
      241 lpyyfhgcgh vvynnslyyh kggsntlvrf efgqetsqtl klenalyfdr kylfanskty
      301 fnlavdekgl wiiyassvdg ssilvaqlde rtfsvvqhvn ttypkskagn afiargilyv
      361 tdtkdmrvtf afdllggkqi nanfdlrtsq svlamlaynm rdqhlyswed ghlmlypvqf
      421 lsttlnq
//
LOCUS       XP_047288387             427 aa            linear   PRI 05-AUG-2025
DEFINITION  gliomedin isoform X3 [Homo sapiens].
ACCESSION   XP_047288387
VERSION     XP_047288387.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432431.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..427
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..427
                     /product="gliomedin isoform X3"
                     /calculated_mol_wt=45691
     Region          <33..>167
                     /region_name="gly_rich_SclB"
                     /note="LPXTG-anchored collagen-like adhesin Scl2/SclB;
                     NF038329"
                     /db_xref="CDD:468478"
     Region          33..88
                     /region_name="Collagen"
                     /note="Collagen triple helix repeat (20 copies);
                     pfam01391"
                     /db_xref="CDD:460189"
     Region          180..420
                     /region_name="OLF"
                     /note="Olfactomedin-like domain; pfam02191"
                     /db_xref="CDD:460482"
     CDS             1..427
                     /gene="GLDN"
                     /gene_synonym="CLOM; COLM; CRG-L2; CRGL2; LCCS11; UNC-112;
                     UNC-122"
                     /coded_by="XM_047432431.1:102..1385"
                     /db_xref="GeneID:342035"
                     /db_xref="HGNC:HGNC:29514"
                     /db_xref="MIM:608603"
ORIGIN      
        1 mvdlcnstkg icltgpsgpp gppgagglpg hngldgqpgp qgpkgekgan gkrgkmgipg
       61 aagnpgerge kgdhgelglq gnegppgqkg ekgdkgdvsn dvllagakgd qgppgppgpp
      121 gppgppgppg srrakgprqp smfngqcpge tcaipnddtl vgkadekase hhspqaesmi
      181 tsignpvqvl kvtetfgtwi resanksddr iwvtehfsgi mvkefkdqps llngsytfih
      241 lpyyfhgcgh vvynnslyyh kggsntlvrf efgqetsqtl klenalyfdr kylfanskty
      301 fnlavdekgl wiiyassvdg ssilvaqlde rtfsvvqhvn ttypkskagn afiargilyv
      361 tdtkdmrvtf afdllggkqi nanfdlrtsq svlamlaynm rdqhlyswed ghlmlypvqf
      421 lsttlnq
//
LOCUS       XP_047288388             421 aa            linear   PRI 05-AUG-2025
DEFINITION  gliomedin isoform X4 [Homo sapiens].
ACCESSION   XP_047288388
VERSION     XP_047288388.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432432.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..421
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..421
                     /product="gliomedin isoform X4"
                     /calculated_mol_wt=45199
     Region          <27..>161
                     /region_name="gly_rich_SclB"
                     /note="LPXTG-anchored collagen-like adhesin Scl2/SclB;
                     NF038329"
                     /db_xref="CDD:468478"
     Region          27..82
                     /region_name="Collagen"
                     /note="Collagen triple helix repeat (20 copies);
                     pfam01391"
                     /db_xref="CDD:460189"
     Region          174..414
                     /region_name="OLF"
                     /note="Olfactomedin-like domain; pfam02191"
                     /db_xref="CDD:460482"
     CDS             1..421
                     /gene="GLDN"
                     /gene_synonym="CLOM; COLM; CRG-L2; CRGL2; LCCS11; UNC-112;
                     UNC-122"
                     /coded_by="XM_047432432.1:47..1312"
                     /db_xref="GeneID:342035"
                     /db_xref="HGNC:HGNC:29514"
                     /db_xref="MIM:608603"
ORIGIN      
        1 mvdlcnstkg icltgppgag glpghngldg qpgpqgpkge kgangkrgkm gipgaagnpg
       61 ergekgdhge lglqgnegpp gqkgekgdkg dvsndvllag akgdqgppgp pgppgppgpp
      121 gppgsrrakg prqpsmfngq cpgetcaipn ddtlvgkade kasehhspqa esmitsignp
      181 vqvlkvtetf gtwiresank sddriwvteh fsgimvkefk dqpsllngsy tfihlpyyfh
      241 gcghvvynns lyyhkggsnt lvrfefgqet sqtlklenal yfdrkylfan sktyfnlavd
      301 ekglwiiyas svdgssilva qldertfsvv qhvnttypks kagnafiarg ilyvtdtkdm
      361 rvtfafdllg gkqinanfdl rtsqsvlaml aynmrdqhly swedghlmly pvqflsttln
      421 q
//
LOCUS       XP_047288389             421 aa            linear   PRI 05-AUG-2025
DEFINITION  gliomedin isoform X4 [Homo sapiens].
ACCESSION   XP_047288389
VERSION     XP_047288389.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432433.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..421
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..421
                     /product="gliomedin isoform X4"
                     /calculated_mol_wt=45199
     Region          <27..>161
                     /region_name="gly_rich_SclB"
                     /note="LPXTG-anchored collagen-like adhesin Scl2/SclB;
                     NF038329"
                     /db_xref="CDD:468478"
     Region          27..82
                     /region_name="Collagen"
                     /note="Collagen triple helix repeat (20 copies);
                     pfam01391"
                     /db_xref="CDD:460189"
     Region          174..414
                     /region_name="OLF"
                     /note="Olfactomedin-like domain; pfam02191"
                     /db_xref="CDD:460482"
     CDS             1..421
                     /gene="GLDN"
                     /gene_synonym="CLOM; COLM; CRG-L2; CRGL2; LCCS11; UNC-112;
                     UNC-122"
                     /coded_by="XM_047432433.1:102..1367"
                     /db_xref="GeneID:342035"
                     /db_xref="HGNC:HGNC:29514"
                     /db_xref="MIM:608603"
ORIGIN      
        1 mvdlcnstkg icltgppgag glpghngldg qpgpqgpkge kgangkrgkm gipgaagnpg
       61 ergekgdhge lglqgnegpp gqkgekgdkg dvsndvllag akgdqgppgp pgppgppgpp
      121 gppgsrrakg prqpsmfngq cpgetcaipn ddtlvgkade kasehhspqa esmitsignp
      181 vqvlkvtetf gtwiresank sddriwvteh fsgimvkefk dqpsllngsy tfihlpyyfh
      241 gcghvvynns lyyhkggsnt lvrfefgqet sqtlklenal yfdrkylfan sktyfnlavd
      301 ekglwiiyas svdgssilva qldertfsvv qhvnttypks kagnafiarg ilyvtdtkdm
      361 rvtfafdllg gkqinanfdl rtsqsvlaml aynmrdqhly swedghlmly pvqflsttln
      421 q
//
LOCUS       XP_016877614             408 aa            linear   PRI 05-AUG-2025
DEFINITION  gliomedin isoform X5 [Homo sapiens].
ACCESSION   XP_016877614
VERSION     XP_016877614.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022125.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..408
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..408
                     /product="gliomedin isoform X5"
                     /calculated_mol_wt=42429
     Region          <157..>270
                     /region_name="gly_rich_SclB"
                     /note="LPXTG-anchored collagen-like adhesin Scl2/SclB;
                     NF038329"
                     /db_xref="CDD:468478"
     Region          157..212
                     /region_name="Collagen"
                     /note="Collagen triple helix repeat (20 copies);
                     pfam01391"
                     /db_xref="CDD:460189"
     Region          304..>402
                     /region_name="OLF"
                     /note="Olfactomedin-like domain; cl02549"
                     /db_xref="CDD:470611"
     CDS             1..408
                     /gene="GLDN"
                     /gene_synonym="CLOM; COLM; CRG-L2; CRGL2; LCCS11; UNC-112;
                     UNC-122"
                     /coded_by="XM_017022125.1:31..1257"
                     /db_xref="GeneID:342035"
                     /db_xref="HGNC:HGNC:29514"
                     /db_xref="MIM:608603"
ORIGIN      
        1 margaeggrg dagwglrgal aavallsaln aagtvfalcq wrglssalra leaqrgreqr
       61 edsalrsfla elsraprgas appqdpassa rnkrshsgep aphiraeshd mlmmmtysmv
      121 pirvmvdlcn stkgicltgp sgppgppgag glpghngldg qpgpqgpkge kgangkrgkm
      181 gipgaagnpg ergekgdhge lglqgnegpp gqkgekgdkg dvsndvllag akgdqgppgp
      241 pgppgppgpp gppgsrrakg prqpsmfngq cpgetcaipn ddtlvgkade kasehhspqa
      301 esmitsignp vqvlkvtetf gtwiresank sddriwvteh fsgimvkefk dqpsllngsy
      361 tfihlpyyfh gcghvvynns lyyhkggsnt lvraflktnf legggarw
//
LOCUS       XP_016877615             284 aa            linear   PRI 05-AUG-2025
DEFINITION  gliomedin isoform X6 [Homo sapiens].
ACCESSION   XP_016877615
VERSION     XP_016877615.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022126.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..284
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..284
                     /product="gliomedin isoform X6"
                     /calculated_mol_wt=29294
     Region          <33..>146
                     /region_name="gly_rich_SclB"
                     /note="LPXTG-anchored collagen-like adhesin Scl2/SclB;
                     NF038329"
                     /db_xref="CDD:468478"
     Region          33..88
                     /region_name="Collagen"
                     /note="Collagen triple helix repeat (20 copies);
                     pfam01391"
                     /db_xref="CDD:460189"
     Region          180..>278
                     /region_name="OLF"
                     /note="Olfactomedin-like domain; cl02549"
                     /db_xref="CDD:470611"
     CDS             1..284
                     /gene="GLDN"
                     /gene_synonym="CLOM; COLM; CRG-L2; CRGL2; LCCS11; UNC-112;
                     UNC-122"
                     /coded_by="XM_017022126.3:47..901"
                     /db_xref="GeneID:342035"
                     /db_xref="HGNC:HGNC:29514"
                     /db_xref="MIM:608603"
ORIGIN      
        1 mvdlcnstkg icltgpsgpp gppgagglpg hngldgqpgp qgpkgekgan gkrgkmgipg
       61 aagnpgerge kgdhgelglq gnegppgqkg ekgdkgdvsn dvllagakgd qgppgppgpp
      121 gppgppgppg srrakgprqp smfngqcpge tcaipnddtl vgkadekase hhspqaesmi
      181 tsignpvqvl kvtetfgtwi resanksddr iwvtehfsgi mvkefkdqps llngsytfih
      241 lpyyfhgcgh vvynnslyyh kggsntlvra flktnflegg garw
//
LOCUS       XP_011519806            1419 aa            linear   PRI 05-AUG-2025
DEFINITION  formin-1 isoform X1 [Homo sapiens].
ACCESSION   XP_011519806
VERSION     XP_011519806.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521504.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1419
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1419
                     /product="formin-1 isoform X1"
                     /calculated_mol_wt=157447
     Region          222..>633
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          973..1370
                     /region_name="FH2"
                     /note="Formin Homology 2 Domain; smart00498"
                     /db_xref="CDD:214697"
     CDS             1..1419
                     /gene="FMN1"
                     /gene_synonym="FMN; LD"
                     /coded_by="XM_011521504.4:337..4596"
                     /db_xref="GeneID:342184"
                     /db_xref="HGNC:HGNC:3768"
                     /db_xref="MIM:136535"
ORIGIN      
        1 megthctlql hkpitelcyi sfclpkgevr gfsykgtvtl drsnkgfhnc yqvreesdii
       61 slsqepdehp gdiffkqtpt kdiltelykl ttererlltn llssdhilgi tmgnqegklq
      121 elsvslaped dcfqsagdwq gelpvgplnk rsthgnkkpr rssgrresfg alpqkrtkrk
      181 grggresapl mgkdkicssh slplsrtrpn lwvleekgnl lpngalacsl qrrescppdi
      241 pktpdtdlgf gsfetafkdt glgrevlppd cssteaggdg irrppsgleh qqtglseshq
      301 dpekhpeaek demekpakrt ckqkpvskvv akvqdlssqv qrvvkthskg ketiairpaa
      361 haefvpkadl ltlpgaeaga hgsrrqgker qgdrssqspa getasissvs asaegavnkv
      421 plkviesekl deapegkrlg fpvhtsvpht rpetrnkrra glplgghksl fldlphkvgp
      481 dssqprgdkk kpsppapaal gkvfnnsasq ssthkqtspv psplsprlps pqqhhrilrl
      541 palpgereaa lndspcrksr vfsgcvsadt leppssakvt etkgaspafl ragqprlvpg
      601 etlekslgpg kttaepqhqs ppgissegfp wdgfneqtpk dlpnrdggaw vlgyragpac
      661 pfllheerek snrselyldl hpdhslteqd drtpgrlqav wpppktkdte ekvglkytea
      721 eyqaailhlk rehkeeienl qaqfelrafh irgehamita rleetienlk helehrwrgg
      781 ceerkdvcis tdddcppktf rnvcvqtdre tflkpceses kttrsnqlvp kklnisslsq
      841 lsppndhkdi haalqpmegm asnqqkalpp ppasippppp lpsglgslsp appmppvsag
      901 pplppppppp pplpppssag pppppppppl pnspappnpg gpppappppg lapppppglf
      961 fglgssssqc prkpaiepsc pmkplywtri qisdrsqnat ptlwdsleep dirdpsefey
     1021 lfskdttqqk kkplsetyek knkvkkiikl ldgkrsqtvg ilisslhlem kdiqqaifnv
     1081 ddsvvdletl aalyenraqe delvkirkyy etskeeelkl ldkpeqflhe laqipnfaer
     1141 aqciifrsvf segitslhrk veiitraskd llhvksvkdi lalilafgny mnggnrtrgq
     1201 adgysleilp klkdvksrdn ginlvdyvvk yylryydqea gteksvfplp epqdfflasq
     1261 vkfedlikdl rklkrqleas ekqmvvvcke spkeylqpfk dkleeffqka kkehkmeesh
     1321 lenaqksfet tvryfgmkpk sgekeitpsy vfmvwyefcs dfktiwkres kniskerlkm
     1381 aqesvsklts ekkvetkkin ptaslkerlr qkeasvttn
//
LOCUS       XP_011519807            1364 aa            linear   PRI 05-AUG-2025
DEFINITION  formin-1 isoform X2 [Homo sapiens].
ACCESSION   XP_011519807
VERSION     XP_011519807.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521505.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1364
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1364
                     /product="formin-1 isoform X2"
                     /calculated_mol_wt=150448
     Region          973..1309
                     /region_name="FH2"
                     /note="Formin Homology 2 Domain; smart00498"
                     /db_xref="CDD:214697"
     CDS             1..1364
                     /gene="FMN1"
                     /gene_synonym="FMN; LD"
                     /coded_by="XM_011521505.3:215..4309"
                     /db_xref="GeneID:342184"
                     /db_xref="HGNC:HGNC:3768"
                     /db_xref="MIM:136535"
ORIGIN      
        1 megthctlql hkpitelcyi sfclpkgevr gfsykgtvtl drsnkgfhnc yqvreesdii
       61 slsqepdehp gdiffkqtpt kdiltelykl ttererlltn llssdhilgi tmgnqegklq
      121 elsvslaped dcfqsagdwq gelpvgplnk rsthgnkkpr rssgrresfg alpqkrtkrk
      181 grggresapl mgkdkicssh slplsrtrpn lwvleekgnl lpngalacsl qrrescppdi
      241 pktpdtdlgf gsfetafkdt glgrevlppd cssteaggdg irrppsgleh qqtglseshq
      301 dpekhpeaek demekpakrt ckqkpvskvv akvqdlssqv qrvvkthskg ketiairpaa
      361 haefvpkadl ltlpgaeaga hgsrrqgker qgdrssqspa getasissvs asaegavnkv
      421 plkviesekl deapegkrlg fpvhtsvpht rpetrnkrra glplgghksl fldlphkvgp
      481 dssqprgdkk kpsppapaal gkvfnnsasq ssthkqtspv psplsprlps pqqhhrilrl
      541 palpgereaa lndspcrksr vfsgcvsadt leppssakvt etkgaspafl ragqprlvpg
      601 etlekslgpg kttaepqhqs ppgissegfp wdgfneqtpk dlpnrdggaw vlgyragpac
      661 pfllheerek snrselyldl hpdhslteqd drtpgrlqav wpppktkdte ekvglkytea
      721 eyqaailhlk rehkeeienl qaqfelrafh irgehamita rleetienlk helehrwrgg
      781 ceerkdvcis tdddcppktf rnvcvqtdre tflkpceses kttrsnqlvp kklnisslsq
      841 lsppndhkdi haalqpmegm asnqqkalpp ppasippppp lpsglgslsp appmppvsag
      901 pplppppppp pplpppssag pppppppppl pnspappnpg gpppappppg lapppppglf
      961 fglgssssqc prkpaiepsc pmkplywtri qisdrsqnat ptlwdsleep dirdpsefey
     1021 lfskdttqqk kkplsetyek knkvkkiikl ldgkrsqtvg ilisslhlem kdiqqaifnv
     1081 ddsvvdletl aalyenraqe delvkirkyy etskeeelkl ldkpeqflhe laqipnfaer
     1141 aqciifrsvf segitslhrk veiitraskd llhvksvkdi lalilafgny mnggnrtrgq
     1201 adgysleilp klkdvksrdn ginlvdyvvk yylryydqea gteksvfplp epqdfflasq
     1261 vkfedlikdl rklkrqleas ekqmvvvcke spkeylqpfk dkleeffqkg hpfpmsacca
     1321 svgvkhlfll esaqrgfskk wktiatltsd gshvkqsavp lfpr
//
LOCUS       XP_016877620            1343 aa            linear   PRI 05-AUG-2025
DEFINITION  formin-1 isoform X3 [Homo sapiens].
ACCESSION   XP_016877620
VERSION     XP_016877620.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022131.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1343
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1343
                     /product="formin-1 isoform X3"
                     /calculated_mol_wt=148029
     Region          973..1310
                     /region_name="FH2"
                     /note="Formin Homology 2 Domain; smart00498"
                     /db_xref="CDD:214697"
     CDS             1..1343
                     /gene="FMN1"
                     /gene_synonym="FMN; LD"
                     /coded_by="XM_017022131.2:215..4246"
                     /db_xref="GeneID:342184"
                     /db_xref="HGNC:HGNC:3768"
                     /db_xref="MIM:136535"
ORIGIN      
        1 megthctlql hkpitelcyi sfclpkgevr gfsykgtvtl drsnkgfhnc yqvreesdii
       61 slsqepdehp gdiffkqtpt kdiltelykl ttererlltn llssdhilgi tmgnqegklq
      121 elsvslaped dcfqsagdwq gelpvgplnk rsthgnkkpr rssgrresfg alpqkrtkrk
      181 grggresapl mgkdkicssh slplsrtrpn lwvleekgnl lpngalacsl qrrescppdi
      241 pktpdtdlgf gsfetafkdt glgrevlppd cssteaggdg irrppsgleh qqtglseshq
      301 dpekhpeaek demekpakrt ckqkpvskvv akvqdlssqv qrvvkthskg ketiairpaa
      361 haefvpkadl ltlpgaeaga hgsrrqgker qgdrssqspa getasissvs asaegavnkv
      421 plkviesekl deapegkrlg fpvhtsvpht rpetrnkrra glplgghksl fldlphkvgp
      481 dssqprgdkk kpsppapaal gkvfnnsasq ssthkqtspv psplsprlps pqqhhrilrl
      541 palpgereaa lndspcrksr vfsgcvsadt leppssakvt etkgaspafl ragqprlvpg
      601 etlekslgpg kttaepqhqs ppgissegfp wdgfneqtpk dlpnrdggaw vlgyragpac
      661 pfllheerek snrselyldl hpdhslteqd drtpgrlqav wpppktkdte ekvglkytea
      721 eyqaailhlk rehkeeienl qaqfelrafh irgehamita rleetienlk helehrwrgg
      781 ceerkdvcis tdddcppktf rnvcvqtdre tflkpceses kttrsnqlvp kklnisslsq
      841 lsppndhkdi haalqpmegm asnqqkalpp ppasippppp lpsglgslsp appmppvsag
      901 pplppppppp pplpppssag pppppppppl pnspappnpg gpppappppg lapppppglf
      961 fglgssssqc prkpaiepsc pmkplywtri qisdrsqnat ptlwdsleep dirdpsefey
     1021 lfskdttqqk kkplsetyek knkvkkiikl ldgkrsqtvg ilisslhlem kdiqqaifnv
     1081 ddsvvdletl aalyenraqe delvkirkyy etskeeelkl ldkpeqflhe laqipnfaer
     1141 aqciifrsvf segitslhrk veiitraskd llhvksvkdi lalilafgny mnggnrtrgq
     1201 adgysleilp klkdvksrdn ginlvdyvvk yylryydqea gteksvfplp epqdfflasq
     1261 vkfedlikdl rklkrqleas ekqmvvvcke spkeylqpfk dkleeffqka gssssqslnt
     1321 rglqdsvhep lalslgllrc iep
//
LOCUS       XP_047288392            1321 aa            linear   PRI 05-AUG-2025
DEFINITION  formin-1 isoform X4 [Homo sapiens].
ACCESSION   XP_047288392
VERSION     XP_047288392.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432436.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1321
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1321
                     /product="formin-1 isoform X4"
                     /calculated_mol_wt=146374
     Region          875..1272
                     /region_name="FH2"
                     /note="Formin Homology 2 Domain; smart00498"
                     /db_xref="CDD:214697"
     CDS             1..1321
                     /gene="FMN1"
                     /gene_synonym="FMN; LD"
                     /coded_by="XM_047432436.1:215..4180"
                     /db_xref="GeneID:342184"
                     /db_xref="HGNC:HGNC:3768"
                     /db_xref="MIM:136535"
ORIGIN      
        1 megthctlql hkpitelcyi sfclpkgevr gfsykgtvtl drsnkgfhnc yqvreesdii
       61 slsqepdehp gdiffkqtpt kdiltelykl ttererlltn llssdhilgi tmgnqegklq
      121 elsvslaped dcfqsagdwq gelpvgplnk rsthgnkkpr rssgrresfg alpqkrtkrk
      181 grggresapl mgkdkicssh slplsrtrpn lwvleekgnl lpngalacsl qrrescppdi
      241 pktpdtdlgf gsfetafkdt glgrevlppd cssteaggdg irrppsgleh qqtglseshq
      301 dpekhpeaek demekpakrt ckqkpvskvv akvqdlssqv qrvvkthskg ketiairpaa
      361 haefvpkadl ltlpgaeaga hgsrrqgker qgdrssqspa getasissvs asaegavnkv
      421 plkviesekl deapegkrlg fpvhtsvpht rpetrnkrra glplgghksl fldlphkvgp
      481 dssqprgdkk kpsppapaal gkvfnnsasq ssthkqtspv psplsprlps pqqhhrilrl
      541 palpgereaa lndspcrksr vfsgcvsadt leppssakvt etkgaspafl ragqprlvpg
      601 etlekslgpg kttaepqhqs ppeyqaailh lkrehkeeie nlqaqfelra fhirgehami
      661 tarleetien lkhelehrwr ggceerkdvc istdddcppk tfrnvcvqtd retflkpces
      721 eskttrsnql vpkklnissl sqlsppndhk dihaalqpme gmasnqqkal ppppasippp
      781 pplpsglgsl spappmppvs agpplppppp pppplpppss agpppppppp plpnspappn
      841 pggpppappp pglapppppg lffglgssss qcprkpaiep scpmkplywt riqisdrsqn
      901 atptlwdsle epdirdpsef eylfskdttq qkkkplsety ekknkvkkii klldgkrsqt
      961 vgilisslhl emkdiqqaif nvddsvvdle tlaalyenra qedelvkirk yyetskeeel
     1021 klldkpeqfl helaqipnfa eraqciifrs vfsegitslh rkveiitras kdllhvksvk
     1081 dilalilafg nymnggnrtr gqadgyslei lpklkdvksr dnginlvdyv vkyylryydq
     1141 eagteksvfp lpepqdffla sqvkfedlik dlrklkrqle asekqmvvvc kespkeylqp
     1201 fkdkleeffq kakkehkmee shlenaqksf ettvryfgmk pksgekeitp syvfmvwyef
     1261 csdfktiwkr eskniskerl kmaqesvskl tsekkvetkk inptaslker lrqkeasvtt
     1321 n
//
LOCUS       XP_011519809            1291 aa            linear   PRI 05-AUG-2025
DEFINITION  formin-1 isoform X5 [Homo sapiens].
ACCESSION   XP_011519809
VERSION     XP_011519809.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521507.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1291
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1291
                     /product="formin-1 isoform X5"
                     /calculated_mol_wt=142359
     Region          973..>1284
                     /region_name="FH2"
                     /note="Formin Homology 2 Domain; smart00498"
                     /db_xref="CDD:214697"
     CDS             1..1291
                     /gene="FMN1"
                     /gene_synonym="FMN; LD"
                     /coded_by="XM_011521507.3:215..4090"
                     /db_xref="GeneID:342184"
                     /db_xref="HGNC:HGNC:3768"
                     /db_xref="MIM:136535"
ORIGIN      
        1 megthctlql hkpitelcyi sfclpkgevr gfsykgtvtl drsnkgfhnc yqvreesdii
       61 slsqepdehp gdiffkqtpt kdiltelykl ttererlltn llssdhilgi tmgnqegklq
      121 elsvslaped dcfqsagdwq gelpvgplnk rsthgnkkpr rssgrresfg alpqkrtkrk
      181 grggresapl mgkdkicssh slplsrtrpn lwvleekgnl lpngalacsl qrrescppdi
      241 pktpdtdlgf gsfetafkdt glgrevlppd cssteaggdg irrppsgleh qqtglseshq
      301 dpekhpeaek demekpakrt ckqkpvskvv akvqdlssqv qrvvkthskg ketiairpaa
      361 haefvpkadl ltlpgaeaga hgsrrqgker qgdrssqspa getasissvs asaegavnkv
      421 plkviesekl deapegkrlg fpvhtsvpht rpetrnkrra glplgghksl fldlphkvgp
      481 dssqprgdkk kpsppapaal gkvfnnsasq ssthkqtspv psplsprlps pqqhhrilrl
      541 palpgereaa lndspcrksr vfsgcvsadt leppssakvt etkgaspafl ragqprlvpg
      601 etlekslgpg kttaepqhqs ppgissegfp wdgfneqtpk dlpnrdggaw vlgyragpac
      661 pfllheerek snrselyldl hpdhslteqd drtpgrlqav wpppktkdte ekvglkytea
      721 eyqaailhlk rehkeeienl qaqfelrafh irgehamita rleetienlk helehrwrgg
      781 ceerkdvcis tdddcppktf rnvcvqtdre tflkpceses kttrsnqlvp kklnisslsq
      841 lsppndhkdi haalqpmegm asnqqkalpp ppasippppp lpsglgslsp appmppvsag
      901 pplppppppp pplpppssag pppppppppl pnspappnpg gpppappppg lapppppglf
      961 fglgssssqc prkpaiepsc pmkplywtri qisdrsqnat ptlwdsleep dirdpsefey
     1021 lfskdttqqk kkplsetyek knkvkkiikl ldgkrsqtvg ilisslhlem kdiqqaifnv
     1081 ddsvvdletl aalyenraqe delvkirkyy etskeeelkl ldkpeqflhe laqipnfaer
     1141 aqciifrsvf segitslhrk veiitraskd llhvksvkdi lalilafgny mnggnrtrgq
     1201 adgysleilp klkdvksrdn ginlvdyvvk yylryydqea gteksvfplp epqdfflasq
     1261 vkfedlikdl rklkrqlevi frmllkkvls h
//
LOCUS       XP_047288393            1266 aa            linear   PRI 05-AUG-2025
DEFINITION  formin-1 isoform X6 [Homo sapiens].
ACCESSION   XP_047288393
VERSION     XP_047288393.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432437.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1266
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1266
                     /product="formin-1 isoform X6"
                     /calculated_mol_wt=139374
     Region          875..1211
                     /region_name="FH2"
                     /note="Formin Homology 2 Domain; smart00498"
                     /db_xref="CDD:214697"
     CDS             1..1266
                     /gene="FMN1"
                     /gene_synonym="FMN; LD"
                     /coded_by="XM_047432437.1:215..4015"
                     /db_xref="GeneID:342184"
                     /db_xref="HGNC:HGNC:3768"
                     /db_xref="MIM:136535"
ORIGIN      
        1 megthctlql hkpitelcyi sfclpkgevr gfsykgtvtl drsnkgfhnc yqvreesdii
       61 slsqepdehp gdiffkqtpt kdiltelykl ttererlltn llssdhilgi tmgnqegklq
      121 elsvslaped dcfqsagdwq gelpvgplnk rsthgnkkpr rssgrresfg alpqkrtkrk
      181 grggresapl mgkdkicssh slplsrtrpn lwvleekgnl lpngalacsl qrrescppdi
      241 pktpdtdlgf gsfetafkdt glgrevlppd cssteaggdg irrppsgleh qqtglseshq
      301 dpekhpeaek demekpakrt ckqkpvskvv akvqdlssqv qrvvkthskg ketiairpaa
      361 haefvpkadl ltlpgaeaga hgsrrqgker qgdrssqspa getasissvs asaegavnkv
      421 plkviesekl deapegkrlg fpvhtsvpht rpetrnkrra glplgghksl fldlphkvgp
      481 dssqprgdkk kpsppapaal gkvfnnsasq ssthkqtspv psplsprlps pqqhhrilrl
      541 palpgereaa lndspcrksr vfsgcvsadt leppssakvt etkgaspafl ragqprlvpg
      601 etlekslgpg kttaepqhqs ppeyqaailh lkrehkeeie nlqaqfelra fhirgehami
      661 tarleetien lkhelehrwr ggceerkdvc istdddcppk tfrnvcvqtd retflkpces
      721 eskttrsnql vpkklnissl sqlsppndhk dihaalqpme gmasnqqkal ppppasippp
      781 pplpsglgsl spappmppvs agpplppppp pppplpppss agpppppppp plpnspappn
      841 pggpppappp pglapppppg lffglgssss qcprkpaiep scpmkplywt riqisdrsqn
      901 atptlwdsle epdirdpsef eylfskdttq qkkkplsety ekknkvkkii klldgkrsqt
      961 vgilisslhl emkdiqqaif nvddsvvdle tlaalyenra qedelvkirk yyetskeeel
     1021 klldkpeqfl helaqipnfa eraqciifrs vfsegitslh rkveiitras kdllhvksvk
     1081 dilalilafg nymnggnrtr gqadgyslei lpklkdvksr dnginlvdyv vkyylryydq
     1141 eagteksvfp lpepqdffla sqvkfedlik dlrklkrqle asekqmvvvc kespkeylqp
     1201 fkdkleeffq kghpfpmsac casvgvkhlf llesaqrgfs kkwktiatlt sdgshvkqsa
     1261 vplfpr
//
LOCUS       XP_047288394            1141 aa            linear   PRI 05-AUG-2025
DEFINITION  formin-1 isoform X7 [Homo sapiens].
ACCESSION   XP_047288394
VERSION     XP_047288394.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432438.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1141
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1141
                     /product="formin-1 isoform X7"
                     /calculated_mol_wt=125026
     Region          73..>295
                     /region_name="PTZ00459"
                     /note="mucin-associated surface protein (MASP);
                     Provisional"
                     /db_xref="CDD:185638"
     Region          750..1086
                     /region_name="FH2"
                     /note="Formin Homology 2 Domain; smart00498"
                     /db_xref="CDD:214697"
     CDS             1..1141
                     /gene="FMN1"
                     /gene_synonym="FMN; LD"
                     /coded_by="XM_047432438.1:291..3716"
                     /db_xref="GeneID:342184"
                     /db_xref="HGNC:HGNC:3768"
                     /db_xref="MIM:136535"
ORIGIN      
        1 menvdnsldg sdvsepakpe aglevaqsil skfsmkslfg ftsklesvnp eeedavlkaf
       61 hsldvnptsq qddssngldp qeagsrvspd lgndekiasv etesegsqrk eagtsllaqe
      121 llplstlkgt kddvicvrgt lvhttsdsds ddggqepeeg sstngpksps gvlsepsqes
      181 kenpggfren tvtgemngae lcaedpqrip pemsskleag ngglqterrp sqdqvgeegs
      241 qdlpavtnqn ssvgitesas skkevsgeks fqlpaffsgl rvlkkgatae ggetiteikp
      301 kdgdlallkl tqpvqkslvq aglqtvksek katdpkatpt lleqlsllln idmpktepkg
      361 adpesprree mgcnadqesq sgpgvpqtqg gevkpkspet aleafkalfi rpprkgttad
      421 tselealkrk mrhekeslra vfersnskpa dgpsdskspd hslteqddrt pgrlqavwpp
      481 pktkdteekv glkyteaeyq aailhlkreh keeienlqaq felrafhirg ehamitarle
      541 etienlkhel ehrwrggcee rkdvcistdd dcppktfrnv cvqtdretfl kpcesesktt
      601 rsnqlvpkkl nisslsqlsp pndhkdihaa lqpmegmasn qqkalppppa sippppplps
      661 glgslspapp mppvsagppl pppppppppl pppssagppp pppppplpns pappnpggpp
      721 pappppglap ppppglffgl gssssqcprk paiepscpmk plywtriqis drsqnatptl
      781 wdsleepdir dpsefeylfs kdttqqkkkp lsetyekknk vkkiiklldg krsqtvgili
      841 sslhlemkdi qqaifnvdds vvdletlaal yenraqedel vkirkyyets keeelklldk
      901 peqflhelaq ipnfaeraqc iifrsvfseg itslhrkvei itraskdllh vksvkdilal
      961 ilafgnymng gnrtrgqadg ysleilpklk dvksrdngin lvdyvvkyyl ryydqeagte
     1021 ksvfplpepq dfflasqvkf edlikdlrkl krqleasekq mvvvckespk eylqpfkdkl
     1081 eeffqkghpf pmsaccasvg vkhlfllesa qrgfskkwkt iatltsdgsh vkqsavplfp
     1141 r
//
LOCUS       XP_047288395            1120 aa            linear   PRI 05-AUG-2025
DEFINITION  formin-1 isoform X8 [Homo sapiens].
ACCESSION   XP_047288395
VERSION     XP_047288395.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432439.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1120
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1120
                     /product="formin-1 isoform X8"
                     /calculated_mol_wt=122607
     Region          73..>295
                     /region_name="PTZ00459"
                     /note="mucin-associated surface protein (MASP);
                     Provisional"
                     /db_xref="CDD:185638"
     Region          750..1087
                     /region_name="FH2"
                     /note="Formin Homology 2 Domain; smart00498"
                     /db_xref="CDD:214697"
     CDS             1..1120
                     /gene="FMN1"
                     /gene_synonym="FMN; LD"
                     /coded_by="XM_047432439.1:291..3653"
                     /db_xref="GeneID:342184"
                     /db_xref="HGNC:HGNC:3768"
                     /db_xref="MIM:136535"
ORIGIN      
        1 menvdnsldg sdvsepakpe aglevaqsil skfsmkslfg ftsklesvnp eeedavlkaf
       61 hsldvnptsq qddssngldp qeagsrvspd lgndekiasv etesegsqrk eagtsllaqe
      121 llplstlkgt kddvicvrgt lvhttsdsds ddggqepeeg sstngpksps gvlsepsqes
      181 kenpggfren tvtgemngae lcaedpqrip pemsskleag ngglqterrp sqdqvgeegs
      241 qdlpavtnqn ssvgitesas skkevsgeks fqlpaffsgl rvlkkgatae ggetiteikp
      301 kdgdlallkl tqpvqkslvq aglqtvksek katdpkatpt lleqlsllln idmpktepkg
      361 adpesprree mgcnadqesq sgpgvpqtqg gevkpkspet aleafkalfi rpprkgttad
      421 tselealkrk mrhekeslra vfersnskpa dgpsdskspd hslteqddrt pgrlqavwpp
      481 pktkdteekv glkyteaeyq aailhlkreh keeienlqaq felrafhirg ehamitarle
      541 etienlkhel ehrwrggcee rkdvcistdd dcppktfrnv cvqtdretfl kpcesesktt
      601 rsnqlvpkkl nisslsqlsp pndhkdihaa lqpmegmasn qqkalppppa sippppplps
      661 glgslspapp mppvsagppl pppppppppl pppssagppp pppppplpns pappnpggpp
      721 pappppglap ppppglffgl gssssqcprk paiepscpmk plywtriqis drsqnatptl
      781 wdsleepdir dpsefeylfs kdttqqkkkp lsetyekknk vkkiiklldg krsqtvgili
      841 sslhlemkdi qqaifnvdds vvdletlaal yenraqedel vkirkyyets keeelklldk
      901 peqflhelaq ipnfaeraqc iifrsvfseg itslhrkvei itraskdllh vksvkdilal
      961 ilafgnymng gnrtrgqadg ysleilpklk dvksrdngin lvdyvvkyyl ryydqeagte
     1021 ksvfplpepq dfflasqvkf edlikdlrkl krqleasekq mvvvckespk eylqpfkdkl
     1081 eeffqkagss ssqslntrgl qdsvheplal slgllrciep
//
LOCUS       XP_011519811             869 aa            linear   PRI 05-AUG-2025
DEFINITION  formin-1 isoform X9 [Homo sapiens].
ACCESSION   XP_011519811
VERSION     XP_011519811.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521509.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..869
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..869
                     /product="formin-1 isoform X9"
                     /calculated_mol_wt=98427
     Region          423..820
                     /region_name="FH2"
                     /note="Formin Homology 2 Domain; smart00498"
                     /db_xref="CDD:214697"
     CDS             1..869
                     /gene="FMN1"
                     /gene_synonym="FMN; LD"
                     /coded_by="XM_011521509.4:138..2747"
                     /db_xref="GeneID:342184"
                     /db_xref="HGNC:HGNC:3768"
                     /db_xref="MIM:136535"
ORIGIN      
        1 mtftitvfff fhhhhhhhch yhhlqghyhh sisvppself kfckgrfskg mpggitffts
       61 phldpaqaka dlgissegfp wdgfneqtpk dlpnrdggaw vlgyragpac pfllheerek
      121 snrselyldl hpdhslteqd drtpgrlqav wpppktkdte ekvglkytea eyqaailhlk
      181 rehkeeienl qaqfelrafh irgehamita rleetienlk helehrwrgg ceerkdvcis
      241 tdddcppktf rnvcvqtdre tflkpceses kttrsnqlvp kklnisslsq lsppndhkdi
      301 haalqpmegm asnqqkalpp ppasippppp lpsglgslsp appmppvsag pplppppppp
      361 pplpppssag pppppppppl pnspappnpg gpppappppg lapppppglf fglgssssqc
      421 prkpaiepsc pmkplywtri qisdrsqnat ptlwdsleep dirdpsefey lfskdttqqk
      481 kkplsetyek knkvkkiikl ldgkrsqtvg ilisslhlem kdiqqaifnv ddsvvdletl
      541 aalyenraqe delvkirkyy etskeeelkl ldkpeqflhe laqipnfaer aqciifrsvf
      601 segitslhrk veiitraskd llhvksvkdi lalilafgny mnggnrtrgq adgysleilp
      661 klkdvksrdn ginlvdyvvk yylryydqea gteksvfplp epqdfflasq vkfedlikdl
      721 rklkrqleas ekqmvvvcke spkeylqpfk dkleeffqka kkehkmeesh lenaqksfet
      781 tvryfgmkpk sgekeitpsy vfmvwyefcs dfktiwkres kniskerlkm aqesvsklts
      841 ekkvetkkin ptaslkerlr qkeasvttn
//
LOCUS       XP_016877621             841 aa            linear   PRI 05-AUG-2025
DEFINITION  formin-1 isoform X10 [Homo sapiens].
ACCESSION   XP_016877621
VERSION     XP_016877621.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022132.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..841
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..841
                     /product="formin-1 isoform X10"
                     /calculated_mol_wt=95038
     Region          395..792
                     /region_name="FH2"
                     /note="Formin Homology 2 Domain; smart00498"
                     /db_xref="CDD:214697"
     CDS             1..841
                     /gene="FMN1"
                     /gene_synonym="FMN; LD"
                     /coded_by="XM_017022132.3:80..2605"
                     /db_xref="GeneID:342184"
                     /db_xref="HGNC:HGNC:3768"
                     /db_xref="MIM:136535"
ORIGIN      
        1 mfttgsppfg tmgacyhcsp rygqsisvpr iwkcrhrrsv tpeegisseg fpwdgfneqt
       61 pkdlpnrdgg awvlgyragp acpfllheer eksnrselyl dlhpdhslte qddrtpgrlq
      121 avwpppktkd teekvglkyt eaeyqaailh lkrehkeeie nlqaqfelra fhirgehami
      181 tarleetien lkhelehrwr ggceerkdvc istdddcppk tfrnvcvqtd retflkpces
      241 eskttrsnql vpkklnissl sqlsppndhk dihaalqpme gmasnqqkal ppppasippp
      301 pplpsglgsl spappmppvs agpplppppp pppplpppss agpppppppp plpnspappn
      361 pggpppappp pglapppppg lffglgssss qcprkpaiep scpmkplywt riqisdrsqn
      421 atptlwdsle epdirdpsef eylfskdttq qkkkplsety ekknkvkkii klldgkrsqt
      481 vgilisslhl emkdiqqaif nvddsvvdle tlaalyenra qedelvkirk yyetskeeel
      541 klldkpeqfl helaqipnfa eraqciifrs vfsegitslh rkveiitras kdllhvksvk
      601 dilalilafg nymnggnrtr gqadgyslei lpklkdvksr dnginlvdyv vkyylryydq
      661 eagteksvfp lpepqdffla sqvkfedlik dlrklkrqle asekqmvvvc kespkeylqp
      721 fkdkleeffq kakkehkmee shlenaqksf ettvryfgmk pksgekeitp syvfmvwyef
      781 csdfktiwkr eskniskerl kmaqesvskl tsekkvetkk inptaslker lrqkeasvtt
      841 n
//
LOCUS       XP_011519813             827 aa            linear   PRI 05-AUG-2025
DEFINITION  formin-1 isoform X11 [Homo sapiens].
ACCESSION   XP_011519813
VERSION     XP_011519813.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521511.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..827
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..827
                     /product="formin-1 isoform X11"
                     /calculated_mol_wt=93218
     Region          381..778
                     /region_name="FH2"
                     /note="Formin Homology 2 Domain; smart00498"
                     /db_xref="CDD:214697"
     CDS             1..827
                     /gene="FMN1"
                     /gene_synonym="FMN; LD"
                     /coded_by="XM_011521511.4:382..2865"
                     /db_xref="GeneID:342184"
                     /db_xref="HGNC:HGNC:3768"
                     /db_xref="MIM:136535"
ORIGIN      
        1 meagsevehq esnaqcstwg pcleggevte gissegfpwd gfneqtpkdl pnrdggawvl
       61 gyragpacpf llheereksn rselyldlhp dhslteqddr tpgrlqavwp ppktkdteek
      121 vglkyteaey qaailhlkre hkeeienlqa qfelrafhir gehamitarl eetienlkhe
      181 lehrwrggce erkdvcistd ddcppktfrn vcvqtdretf lkpceseskt trsnqlvpkk
      241 lnisslsqls ppndhkdiha alqpmegmas nqqkalpppp asippppplp sglgslspap
      301 pmppvsagpp lppppppppp lpppssagpp ppppppplpn spappnpggp ppappppgla
      361 pppppglffg lgssssqcpr kpaiepscpm kplywtriqi sdrsqnatpt lwdsleepdi
      421 rdpsefeylf skdttqqkkk plsetyekkn kvkkiiklld gkrsqtvgil isslhlemkd
      481 iqqaifnvdd svvdletlaa lyenraqede lvkirkyyet skeeelklld kpeqflhela
      541 qipnfaeraq ciifrsvfse gitslhrkve iitraskdll hvksvkdila lilafgnymn
      601 ggnrtrgqad gysleilpkl kdvksrdngi nlvdyvvkyy lryydqeagt eksvfplpep
      661 qdfflasqvk fedlikdlrk lkrqleasek qmvvvckesp keylqpfkdk leeffqkakk
      721 ehkmeeshle naqksfettv ryfgmkpksg ekeitpsyvf mvwyefcsdf ktiwkreskn
      781 iskerlkmaq esvskltsek kvetkkinpt aslkerlrqk easvttn
//
LOCUS       XP_047288396             809 aa            linear   PRI 05-AUG-2025
DEFINITION  formin-1 isoform X12 [Homo sapiens].
ACCESSION   XP_047288396
VERSION     XP_047288396.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432440.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..809
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..809
                     /product="formin-1 isoform X12"
                     /calculated_mol_wt=91332
     Region          363..760
                     /region_name="FH2"
                     /note="Formin Homology 2 Domain; smart00498"
                     /db_xref="CDD:214697"
     CDS             1..809
                     /gene="FMN1"
                     /gene_synonym="FMN; LD"
                     /coded_by="XM_047432440.1:1485..3914"
                     /db_xref="GeneID:342184"
                     /db_xref="HGNC:HGNC:3768"
                     /db_xref="MIM:136535"
ORIGIN      
        1 mtllveravs slgaslltpw shhplqrsrr pkeparpsse qanlgwclgk lwkrawgqgr
       61 pqlspstshl qpdhslteqd drtpgrlqav wpppktkdte ekvglkytea eyqaailhlk
      121 rehkeeienl qaqfelrafh irgehamita rleetienlk helehrwrgg ceerkdvcis
      181 tdddcppktf rnvcvqtdre tflkpceses kttrsnqlvp kklnisslsq lsppndhkdi
      241 haalqpmegm asnqqkalpp ppasippppp lpsglgslsp appmppvsag pplppppppp
      301 pplpppssag pppppppppl pnspappnpg gpppappppg lapppppglf fglgssssqc
      361 prkpaiepsc pmkplywtri qisdrsqnat ptlwdsleep dirdpsefey lfskdttqqk
      421 kkplsetyek knkvkkiikl ldgkrsqtvg ilisslhlem kdiqqaifnv ddsvvdletl
      481 aalyenraqe delvkirkyy etskeeelkl ldkpeqflhe laqipnfaer aqciifrsvf
      541 segitslhrk veiitraskd llhvksvkdi lalilafgny mnggnrtrgq adgysleilp
      601 klkdvksrdn ginlvdyvvk yylryydqea gteksvfplp epqdfflasq vkfedlikdl
      661 rklkrqleas ekqmvvvcke spkeylqpfk dkleeffqka kkehkmeesh lenaqksfet
      721 tvryfgmkpk sgekeitpsy vfmvwyefcs dfktiwkres kniskerlkm aqesvsklts
      781 ekkvetkkin ptaslkerlr qkeasvttn
//
LOCUS       XP_016877623             808 aa            linear   PRI 05-AUG-2025
DEFINITION  formin-1 isoform X13 [Homo sapiens].
ACCESSION   XP_016877623
VERSION     XP_016877623.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022134.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..808
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..808
                     /product="formin-1 isoform X13"
                     /calculated_mol_wt=91319
     Region          362..759
                     /region_name="FH2"
                     /note="Formin Homology 2 Domain; smart00498"
                     /db_xref="CDD:214697"
     CDS             1..808
                     /gene="FMN1"
                     /gene_synonym="FMN; LD"
                     /coded_by="XM_017022134.3:2236..4662"
                     /db_xref="GeneID:342184"
                     /db_xref="HGNC:HGNC:3768"
                     /db_xref="MIM:136535"
ORIGIN      
        1 msqrpamhll lgissegfpw dgfneqtpkd lpnrdggawv lgyragpacp fllheereks
       61 nrselyldlh pdhslteqdd rtpgrlqavw pppktkdtee kvglkyteae yqaailhlkr
      121 ehkeeienlq aqfelrafhi rgehamitar leetienlkh elehrwrggc eerkdvcist
      181 dddcppktfr nvcvqtdret flkpcesesk ttrsnqlvpk klnisslsql sppndhkdih
      241 aalqpmegma snqqkalppp pasipppppl psglgslspa ppmppvsagp plpppppppp
      301 plpppssagp pppppppplp nspappnpgg pppappppgl apppppglff glgssssqcp
      361 rkpaiepscp mkplywtriq isdrsqnatp tlwdsleepd irdpsefeyl fskdttqqkk
      421 kplsetyekk nkvkkiikll dgkrsqtvgi lisslhlemk diqqaifnvd dsvvdletla
      481 alyenraqed elvkirkyye tskeeelkll dkpeqflhel aqipnfaera qciifrsvfs
      541 egitslhrkv eiitraskdl lhvksvkdil alilafgnym nggnrtrgqa dgysleilpk
      601 lkdvksrdng inlvdyvvky ylryydqeag teksvfplpe pqdfflasqv kfedlikdlr
      661 klkrqlease kqmvvvckes pkeylqpfkd kleeffqkak kehkmeeshl enaqksfett
      721 vryfgmkpks gekeitpsyv fmvwyefcsd fktiwkresk niskerlkma qesvskltse
      781 kkvetkkinp taslkerlrq keasvttn
//
LOCUS       XP_047288397             734 aa            linear   PRI 05-AUG-2025
DEFINITION  formin-1 isoform X14 [Homo sapiens].
ACCESSION   XP_047288397
VERSION     XP_047288397.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432441.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..734
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..734
                     /product="formin-1 isoform X14"
                     /calculated_mol_wt=83027
     Region          288..685
                     /region_name="FH2"
                     /note="Formin Homology 2 Domain; smart00498"
                     /db_xref="CDD:214697"
     CDS             1..734
                     /gene="FMN1"
                     /gene_synonym="FMN; LD"
                     /coded_by="XM_047432441.1:348..2552"
                     /db_xref="GeneID:342184"
                     /db_xref="HGNC:HGNC:3768"
                     /db_xref="MIM:136535"
ORIGIN      
        1 marvrsfile vsetkntpip dtmvqriqmk rcigqeyqaa ilhlkrehke eienlqaqfe
       61 lrafhirgeh amitarleet ienlkheleh rwrggceerk dvcistdddc ppktfrnvcv
      121 qtdretflkp ceseskttrs nqlvpkklni sslsqlsppn dhkdihaalq pmegmasnqq
      181 kalppppasi ppppplpsgl gslspappmp pvsagpplpp ppppppplpp pssagppppp
      241 pppplpnspa ppnpggpppa ppppglappp ppglffglgs sssqcprkpa iepscpmkpl
      301 ywtriqisdr sqnatptlwd sleepdirdp sefeylfskd ttqqkkkpls etyekknkvk
      361 kiiklldgkr sqtvgiliss lhlemkdiqq aifnvddsvv dletlaalye nraqedelvk
      421 irkyyetske eelklldkpe qflhelaqip nfaeraqcii frsvfsegit slhrkveiit
      481 raskdllhvk svkdilalil afgnymnggn rtrgqadgys leilpklkdv ksrdnginlv
      541 dyvvkyylry ydqeagteks vfplpepqdf flasqvkfed likdlrklkr qleasekqmv
      601 vvckespkey lqpfkdklee ffqkakkehk meeshlenaq ksfettvryf gmkpksgeke
      661 itpsyvfmvw yefcsdfkti wkresknisk erlkmaqesv skltsekkve tkkinptasl
      721 kerlrqkeas vttn
//
LOCUS       XP_016877626            1392 aa            linear   PRI 05-AUG-2025
DEFINITION  insulin-like growth factor 1 receptor isoform X1 [Homo sapiens].
ACCESSION   XP_016877626
VERSION     XP_016877626.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022137.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1392
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1392
                     /product="insulin-like growth factor 1 receptor isoform
                     X1"
                     /calculated_mol_wt=157796
     Region          76..186
                     /region_name="Recep_L_domain"
                     /note="Receptor L domain; pfam01030"
                     /db_xref="CDD:460032"
     Region          200..355
                     /region_name="Furin-like"
                     /note="Furin-like cysteine rich region; pfam00757"
                     /db_xref="CDD:395614"
     Region          377..492
                     /region_name="Recep_L_domain"
                     /note="Receptor L domain; pfam01030"
                     /db_xref="CDD:460032"
     Region          519..631
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(620..621,623..624)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          636..>680
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Region          860..949
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(938..939,941..942)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1017..1293
                     /region_name="PTKc_InsR_like"
                     /note="Catalytic domain of Insulin Receptor-like Protein
                     Tyrosine Kinases; cd05032"
                     /db_xref="CDD:173625"
     Site            order(1030,1032..1034,1038,1056,1058,1105,1107,1111,1160,
                     1164..1165,1167,1178,1195..1197,1199..1200,1209,1211,1243)
                     /site_type="active"
                     /db_xref="CDD:173625"
     Site            order(1030,1032..1034,1038,1056,1058,1105,1107,1111,1165,
                     1167,1178)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:173625"
     Site            order(1160,1164,1195..1197,1199..1200,1209,1211,1243)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:173625"
     Site            1177..1202
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:173625"
     CDS             1..1392
                     /gene="IGF1R"
                     /gene_synonym="CD221; IGFIR; IGFR; JTK13"
                     /coded_by="XM_017022137.2:754..4932"
                     /db_xref="GeneID:3480"
                     /db_xref="HGNC:HGNC:5465"
                     /db_xref="MIM:147370"
ORIGIN      
        1 msipswsgpw lpeqekasvr weascsvlpd agwcekells csapwiaqgl petriqvcgp
       61 gidirndyqq lkrlenctvi egylhillis kaedyrsyrf pkltviteyl llfrvagles
      121 lgdlfpnltv irgwklfyny alvifemtnl kdiglynlrn itrgairiek nadlcylstv
      181 dwslildavs nnyivgnkpp kecgdlcpgt meekpmcekt tinneynyrc wttnrcqkmc
      241 pstcgkract ennecchpec lgscsapdnd tacvacrhyy yagvcvpacp pntyrfegwr
      301 cvdrdfcani lsaessdseg fvihdgecmq ecpsgfirng sqsmycipce gpcpkvceee
      361 kktktidsvt saqmlqgcti fkgnllinir rgnniasele nfmglievvt gyvkirhsha
      421 lvslsflknl rlilgeeqle gnysfyvldn qnlqqlwdwd hrnltikagk myfafnpklc
      481 vseiyrmeev tgtkgrqskg dintrnnger ascesdvlhf tstttsknri iitwhryrpp
      541 dyrdlisftv yykeapfknv teydgqdacg snswnmvdvd lppnkdvepg illhglkpwt
      601 qyavyvkavt ltmvendhir gakseilyir tnasvpsipl dvlsasnsss qlivkwnpps
      661 lpngnlsyyi vrwqrqpqdg ylyrhnycsk dkipirkyad gtidieevte npktevcgge
      721 kgpccacpkt eaekqaekee aeyrkvfenf lhnsifvprp erkrrdvmqv anttmssrsr
      781 nttaadtyni tdpeeletey pffesrvdnk ertvisnlrp ftlyridihs cnheaeklgc
      841 sasnfvfart mpaegaddip gpvtweprpe nsiflkwpep enpnglilmy eikygsqved
      901 qrecvsrqey rkyggaklnr lnpgnytari qatslsgngs wtdpvffyvq aktgyenfih
      961 liialpvavl livgglviml yvfhrkrnns rlgngvlyas vnpeyfsaad vyvpdeweva
     1021 rekitmsrel gqgsfgmvye gvakgvvkde petrvaiktv neaasmreri eflneasvmk
     1081 efnchhvvrl lgvvsqgqpt lvimelmtrg dlksylrslr pemennpvla ppslskmiqm
     1141 ageiadgmay lnankfvhrd laarncmvae dftvkigdfg mtrdiyetdy yrkggkgllp
     1201 vrwmspeslk dgvfttysdv wsfgvvlwei atlaeqpyqg lsneqvlrfv megglldkpd
     1261 ncpdmlfelm rmcwqynpkm rpsfleiiss ikeemepgfr evsfyyseen klpepeeldl
     1321 epenmesvpl dpsasssslp lpdrhsghka engpgpgvlv lrasfderqp yahmnggrkn
     1381 eralplpqss tc
//
LOCUS       XP_047288398            1391 aa            linear   PRI 05-AUG-2025
DEFINITION  insulin-like growth factor 1 receptor isoform X2 [Homo sapiens].
ACCESSION   XP_047288398
VERSION     XP_047288398.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432442.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1391
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1391
                     /product="insulin-like growth factor 1 receptor isoform
                     X2"
                     /calculated_mol_wt=157794
     Region          76..186
                     /region_name="Recep_L_domain"
                     /note="Receptor L domain; pfam01030"
                     /db_xref="CDD:460032"
     Region          200..355
                     /region_name="Furin-like"
                     /note="Furin-like cysteine rich region; pfam00757"
                     /db_xref="CDD:395614"
     Region          377..492
                     /region_name="Recep_L_domain"
                     /note="Receptor L domain; pfam01030"
                     /db_xref="CDD:460032"
     Region          519..631
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(620..621,623..624)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          636..>680
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Region          860..949
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(938..939,941..942)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1016..1292
                     /region_name="PTKc_InsR_like"
                     /note="Catalytic domain of Insulin Receptor-like Protein
                     Tyrosine Kinases; cd05032"
                     /db_xref="CDD:173625"
     Site            order(1029,1031..1033,1037,1055,1057,1104,1106,1110,1159,
                     1163..1164,1166,1177,1194..1196,1198..1199,1208,1210,1242)
                     /site_type="active"
                     /db_xref="CDD:173625"
     Site            order(1029,1031..1033,1037,1055,1057,1104,1106,1110,1164,
                     1166,1177)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:173625"
     Site            order(1159,1163,1194..1196,1198..1199,1208,1210,1242)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:173625"
     Site            1176..1201
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:173625"
     CDS             1..1391
                     /gene="IGF1R"
                     /gene_synonym="CD221; IGFIR; IGFR; JTK13"
                     /coded_by="XM_047432442.1:474..4649"
                     /db_xref="GeneID:3480"
                     /db_xref="HGNC:HGNC:5465"
                     /db_xref="MIM:147370"
ORIGIN      
        1 msipswsgpw lpeqekasvr weascsvlpd agwcekells csapwiaqgl petriqvcgp
       61 gidirndyqq lkrlenctvi egylhillis kaedyrsyrf pkltviteyl llfrvagles
      121 lgdlfpnltv irgwklfyny alvifemtnl kdiglynlrn itrgairiek nadlcylstv
      181 dwslildavs nnyivgnkpp kecgdlcpgt meekpmcekt tinneynyrc wttnrcqkmc
      241 pstcgkract ennecchpec lgscsapdnd tacvacrhyy yagvcvpacp pntyrfegwr
      301 cvdrdfcani lsaessdseg fvihdgecmq ecpsgfirng sqsmycipce gpcpkvceee
      361 kktktidsvt saqmlqgcti fkgnllinir rgnniasele nfmglievvt gyvkirhsha
      421 lvslsflknl rlilgeeqle gnysfyvldn qnlqqlwdwd hrnltikagk myfafnpklc
      481 vseiyrmeev tgtkgrqskg dintrnnger ascesdvlhf tstttsknri iitwhryrpp
      541 dyrdlisftv yykeapfknv teydgqdacg snswnmvdvd lppnkdvepg illhglkpwt
      601 qyavyvkavt ltmvendhir gakseilyir tnasvpsipl dvlsasnsss qlivkwnpps
      661 lpngnlsyyi vrwqrqpqdg ylyrhnycsk dkipirkyad gtidieevte npktevcgge
      721 kgpccacpkt eaekqaekee aeyrkvfenf lhnsifvprp erkrrdvmqv anttmssrsr
      781 nttaadtyni tdpeeletey pffesrvdnk ertvisnlrp ftlyridihs cnheaeklgc
      841 sasnfvfart mpaegaddip gpvtweprpe nsiflkwpep enpnglilmy eikygsqved
      901 qrecvsrqey rkyggaklnr lnpgnytari qatslsgngs wtdpvffyvq akryenfihl
      961 iialpvavll ivgglvimly vfhrkrnnsr lgngvlyasv npeyfsaadv yvpdewevar
     1021 ekitmsrelg qgsfgmvyeg vakgvvkdep etrvaiktvn eaasmrerie flneasvmke
     1081 fnchhvvrll gvvsqgqptl vimelmtrgd lksylrslrp emennpvlap pslskmiqma
     1141 geiadgmayl nankfvhrdl aarncmvaed ftvkigdfgm trdiyetdyy rkggkgllpv
     1201 rwmspeslkd gvfttysdvw sfgvvlweia tlaeqpyqgl sneqvlrfvm egglldkpdn
     1261 cpdmlfelmr mcwqynpkmr psfleiissi keemepgfre vsfyyseenk lpepeeldle
     1321 penmesvpld psasssslpl pdrhsghkae ngpgpgvlvl rasfderqpy ahmnggrkne
     1381 ralplpqsst c
//
LOCUS       XP_047288399            1367 aa            linear   PRI 05-AUG-2025
DEFINITION  insulin-like growth factor 1 receptor isoform X3 [Homo sapiens].
ACCESSION   XP_047288399
VERSION     XP_047288399.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432443.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1367
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1367
                     /product="insulin-like growth factor 1 receptor isoform
                     X3"
                     /calculated_mol_wt=154663
     Region          51..161
                     /region_name="Recep_L_domain"
                     /note="Receptor L domain; pfam01030"
                     /db_xref="CDD:460032"
     Region          175..330
                     /region_name="Furin-like"
                     /note="Furin-like cysteine rich region; pfam00757"
                     /db_xref="CDD:395614"
     Region          352..467
                     /region_name="Recep_L_domain"
                     /note="Receptor L domain; pfam01030"
                     /db_xref="CDD:460032"
     Region          494..606
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(595..596,598..599)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          611..>655
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Region          835..924
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(913..914,916..917)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          992..1268
                     /region_name="PTKc_InsR_like"
                     /note="Catalytic domain of Insulin Receptor-like Protein
                     Tyrosine Kinases; cd05032"
                     /db_xref="CDD:173625"
     Site            order(1005,1007..1009,1013,1031,1033,1080,1082,1086,1135,
                     1139..1140,1142,1153,1170..1172,1174..1175,1184,1186,1218)
                     /site_type="active"
                     /db_xref="CDD:173625"
     Site            order(1005,1007..1009,1013,1031,1033,1080,1082,1086,1140,
                     1142,1153)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:173625"
     Site            order(1135,1139,1170..1172,1174..1175,1184,1186,1218)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:173625"
     Site            1152..1177
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:173625"
     CDS             1..1367
                     /gene="IGF1R"
                     /gene_synonym="CD221; IGFIR; IGFR; JTK13"
                     /coded_by="XM_047432443.1:1044..5147"
                     /db_xref="GeneID:3480"
                     /db_xref="HGNC:HGNC:5465"
                     /db_xref="MIM:147370"
ORIGIN      
        1 mksgsgggsp tslwgllfls aalslwptsg eicgpgidir ndyqqlkrle nctviegylh
       61 illiskaedy rsyrfpkltv iteylllfrv agleslgdlf pnltvirgwk lfynyalvif
      121 emtnlkdigl ynlrnitrga irieknadlc ylstvdwsli ldavsnnyiv gnkppkecgd
      181 lcpgtmeekp mcekttinne ynyrcwttnr cqkmcpstcg kractennec chpeclgscs
      241 apdndtacva crhyyyagvc vpacppntyr fegwrcvdrd fcanilsaes sdsegfvihd
      301 gecmqecpsg firngsqsmy cipcegpcpk vceeekktkt idsvtsaqml qgctifkgnl
      361 linirrgnni aselenfmgl ievvtgyvki rhshalvsls flknlrlilg eeqlegnysf
      421 yvldnqnlqq lwdwdhrnlt ikagkmyfaf npklcvseiy rmeevtgtkg rqskgdintr
      481 nngerasces dvlhftsttt sknriiitwh ryrppdyrdl isftvyykea pfknvteydg
      541 qdacgsnswn mvdvdlppnk dvepgillhg lkpwtqyavy vkavtltmve ndhirgakse
      601 ilyirtnasv psipldvlsa snsssqlivk wnppslpngn lsyyivrwqr qpqdgylyrh
      661 nycskdkipi rkyadgtidi eevtenpkte vcggekgpcc acpkteaekq aekeeaeyrk
      721 vfenflhnsi fvprperkrr dvmqvanttm ssrsrnttaa dtynitdpee leteypffes
      781 rvdnkertvi snlrpftlyr idihscnhea eklgcsasnf vfartmpaeg addipgpvtw
      841 eprpensifl kwpepenpng lilmyeikyg sqvedqrecv srqeyrkygg aklnrlnpgn
      901 ytariqatsl sgngswtdpv ffyvqaktgy enfihliial pvavllivgg lvimlyvfhr
      961 krnnsrlgng vlyasvnpey fsaadvyvpd ewevarekit msrelgqgsf gmvyegvakg
     1021 vvkdepetrv aiktvneaas mrerieflne asvmkefnch hvvrllgvvs qgqptlvime
     1081 lmtrgdlksy lrslrpemen npvlappsls kmiqmageia dgmaylnank fvhrdlaarn
     1141 cmvaedftvk igdfgmtrdi yetdyyrkgg kgllpvrwms peslkdgvft tysdvwsfgv
     1201 vlweiatlae qpyqglsneq vlrfvmeggl ldkpdncpdm lfelmrmcwq ynpkmrpsfl
     1261 eiissikeem epgfrevsfy yseenklpep eeldlepenm esvpldpsas ssslplpdrh
     1321 sghkaengpg pgvlvlrasf derqpyahmn ggrkneralp lpqsstc
//
LOCUS       XP_047288400            1366 aa            linear   PRI 05-AUG-2025
DEFINITION  insulin-like growth factor 1 receptor isoform X4 [Homo sapiens].
ACCESSION   XP_047288400
VERSION     XP_047288400.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432444.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1366
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1366
                     /product="insulin-like growth factor 1 receptor isoform
                     X4"
                     /calculated_mol_wt=154661
     Region          51..161
                     /region_name="Recep_L_domain"
                     /note="Receptor L domain; pfam01030"
                     /db_xref="CDD:460032"
     Region          175..330
                     /region_name="Furin-like"
                     /note="Furin-like cysteine rich region; pfam00757"
                     /db_xref="CDD:395614"
     Region          352..467
                     /region_name="Recep_L_domain"
                     /note="Receptor L domain; pfam01030"
                     /db_xref="CDD:460032"
     Region          494..606
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(595..596,598..599)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          611..>655
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Region          835..924
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(913..914,916..917)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          991..1267
                     /region_name="PTKc_InsR_like"
                     /note="Catalytic domain of Insulin Receptor-like Protein
                     Tyrosine Kinases; cd05032"
                     /db_xref="CDD:173625"
     Site            order(1004,1006..1008,1012,1030,1032,1079,1081,1085,1134,
                     1138..1139,1141,1152,1169..1171,1173..1174,1183,1185,1217)
                     /site_type="active"
                     /db_xref="CDD:173625"
     Site            order(1004,1006..1008,1012,1030,1032,1079,1081,1085,1139,
                     1141,1152)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:173625"
     Site            order(1134,1138,1169..1171,1173..1174,1183,1185,1217)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:173625"
     Site            1151..1176
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:173625"
     CDS             1..1366
                     /gene="IGF1R"
                     /gene_synonym="CD221; IGFIR; IGFR; JTK13"
                     /coded_by="XM_047432444.1:1044..5144"
                     /db_xref="GeneID:3480"
                     /db_xref="HGNC:HGNC:5465"
                     /db_xref="MIM:147370"
ORIGIN      
        1 mksgsgggsp tslwgllfls aalslwptsg eicgpgidir ndyqqlkrle nctviegylh
       61 illiskaedy rsyrfpkltv iteylllfrv agleslgdlf pnltvirgwk lfynyalvif
      121 emtnlkdigl ynlrnitrga irieknadlc ylstvdwsli ldavsnnyiv gnkppkecgd
      181 lcpgtmeekp mcekttinne ynyrcwttnr cqkmcpstcg kractennec chpeclgscs
      241 apdndtacva crhyyyagvc vpacppntyr fegwrcvdrd fcanilsaes sdsegfvihd
      301 gecmqecpsg firngsqsmy cipcegpcpk vceeekktkt idsvtsaqml qgctifkgnl
      361 linirrgnni aselenfmgl ievvtgyvki rhshalvsls flknlrlilg eeqlegnysf
      421 yvldnqnlqq lwdwdhrnlt ikagkmyfaf npklcvseiy rmeevtgtkg rqskgdintr
      481 nngerasces dvlhftsttt sknriiitwh ryrppdyrdl isftvyykea pfknvteydg
      541 qdacgsnswn mvdvdlppnk dvepgillhg lkpwtqyavy vkavtltmve ndhirgakse
      601 ilyirtnasv psipldvlsa snsssqlivk wnppslpngn lsyyivrwqr qpqdgylyrh
      661 nycskdkipi rkyadgtidi eevtenpkte vcggekgpcc acpkteaekq aekeeaeyrk
      721 vfenflhnsi fvprperkrr dvmqvanttm ssrsrnttaa dtynitdpee leteypffes
      781 rvdnkertvi snlrpftlyr idihscnhea eklgcsasnf vfartmpaeg addipgpvtw
      841 eprpensifl kwpepenpng lilmyeikyg sqvedqrecv srqeyrkygg aklnrlnpgn
      901 ytariqatsl sgngswtdpv ffyvqakrye nfihliialp vavllivggl vimlyvfhrk
      961 rnnsrlgngv lyasvnpeyf saadvyvpde wevarekitm srelgqgsfg mvyegvakgv
     1021 vkdepetrva iktvneaasm rerieflnea svmkefnchh vvrllgvvsq gqptlvimel
     1081 mtrgdlksyl rslrpemenn pvlappslsk miqmageiad gmaylnankf vhrdlaarnc
     1141 mvaedftvki gdfgmtrdiy etdyyrkggk gllpvrwmsp eslkdgvftt ysdvwsfgvv
     1201 lweiatlaeq pyqglsneqv lrfvmeggll dkpdncpdml felmrmcwqy npkmrpsfle
     1261 iissikeeme pgfrevsfyy seenklpepe eldlepenme svpldpsass sslplpdrhs
     1321 ghkaengpgp gvlvlrasfd erqpyahmng grkneralpl pqsstc
//
LOCUS       XP_047288401            1246 aa            linear   PRI 05-AUG-2025
DEFINITION  insulin-like growth factor 1 receptor isoform X5 [Homo sapiens].
ACCESSION   XP_047288401
VERSION     XP_047288401.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432445.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1246
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1246
                     /product="insulin-like growth factor 1 receptor isoform
                     X5"
                     /calculated_mol_wt=141056
     Region          <1..40
                     /region_name="Recep_L_domain"
                     /note="Receptor L domain; pfam01030"
                     /db_xref="CDD:460032"
     Region          54..209
                     /region_name="Furin-like"
                     /note="Furin-like cysteine rich region; pfam00757"
                     /db_xref="CDD:395614"
     Region          231..346
                     /region_name="Recep_L_domain"
                     /note="Receptor L domain; pfam01030"
                     /db_xref="CDD:460032"
     Region          373..485
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(474..475,477..478)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          490..>534
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Region          714..803
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(792..793,795..796)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          871..1147
                     /region_name="PTKc_InsR_like"
                     /note="Catalytic domain of Insulin Receptor-like Protein
                     Tyrosine Kinases; cd05032"
                     /db_xref="CDD:173625"
     Site            order(884,886..888,892,910,912,959,961,965,1014,
                     1018..1019,1021,1032,1049..1051,1053..1054,1063,1065,1097)
                     /site_type="active"
                     /db_xref="CDD:173625"
     Site            order(884,886..888,892,910,912,959,961,965,1019,1021,1032)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:173625"
     Site            order(1014,1018,1049..1051,1053..1054,1063,1065,1097)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:173625"
     Site            1031..1056
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:173625"
     CDS             1..1246
                     /gene="IGF1R"
                     /gene_synonym="CD221; IGFIR; IGFR; JTK13"
                     /coded_by="XM_047432445.1:380..4120"
                     /db_xref="GeneID:3480"
                     /db_xref="HGNC:HGNC:5465"
                     /db_xref="MIM:147370"
ORIGIN      
        1 mtnlkdigly nlrnitrgai rieknadlcy lstvdwslil davsnnyivg nkppkecgdl
       61 cpgtmeekpm cekttinney nyrcwttnrc qkmcpstcgk ractennecc hpeclgscsa
      121 pdndtacvac rhyyyagvcv pacppntyrf egwrcvdrdf canilsaess dsegfvihdg
      181 ecmqecpsgf irngsqsmyc ipcegpcpkv ceeekktkti dsvtsaqmlq gctifkgnll
      241 inirrgnnia selenfmgli evvtgyvkir hshalvslsf lknlrlilge eqlegnysfy
      301 vldnqnlqql wdwdhrnlti kagkmyfafn pklcvseiyr meevtgtkgr qskgdintrn
      361 ngerascesd vlhftsttts knriiitwhr yrppdyrdli sftvyykeap fknvteydgq
      421 dacgsnswnm vdvdlppnkd vepgillhgl kpwtqyavyv kavtltmven dhirgaksei
      481 lyirtnasvp sipldvlsas nsssqlivkw nppslpngnl syyivrwqrq pqdgylyrhn
      541 ycskdkipir kyadgtidie evtenpktev cggekgpcca cpkteaekqa ekeeaeyrkv
      601 fenflhnsif vprperkrrd vmqvanttms srsrnttaad tynitdpeel eteypffesr
      661 vdnkertvis nlrpftlyri dihscnheae klgcsasnfv fartmpaega ddipgpvtwe
      721 prpensiflk wpepenpngl ilmyeikygs qvedqrecvs rqeyrkygga klnrlnpgny
      781 tariqatsls gngswtdpvf fyvqaktgye nfihliialp vavllivggl vimlyvfhrk
      841 rnnsrlgngv lyasvnpeyf saadvyvpde wevarekitm srelgqgsfg mvyegvakgv
      901 vkdepetrva iktvneaasm rerieflnea svmkefnchh vvrllgvvsq gqptlvimel
      961 mtrgdlksyl rslrpemenn pvlappslsk miqmageiad gmaylnankf vhrdlaarnc
     1021 mvaedftvki gdfgmtrdiy etdyyrkggk gllpvrwmsp eslkdgvftt ysdvwsfgvv
     1081 lweiatlaeq pyqglsneqv lrfvmeggll dkpdncpdml felmrmcwqy npkmrpsfle
     1141 iissikeeme pgfrevsfyy seenklpepe eldlepenme svpldpsass sslplpdrhs
     1201 ghkaengpgp gvlvlrasfd erqpyahmng grkneralpl pqsstc
//
LOCUS       XP_011519818            1064 aa            linear   PRI 05-AUG-2025
DEFINITION  insulin-like growth factor 1 receptor isoform X6 [Homo sapiens].
ACCESSION   XP_011519818
VERSION     XP_011519818.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521516.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1064
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1064
                     /product="insulin-like growth factor 1 receptor isoform
                     X6"
                     /calculated_mol_wt=120695
     Region          <1..27
                     /region_name="Furin-like"
                     /note="Furin-like cysteine rich region; pfam00757"
                     /db_xref="CDD:395614"
     Region          49..164
                     /region_name="Recep_L_domain"
                     /note="Receptor L domain; pfam01030"
                     /db_xref="CDD:460032"
     Region          191..303
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(292..293,295..296)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          308..>352
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Region          532..621
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(610..611,613..614)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          689..965
                     /region_name="PTKc_InsR_like"
                     /note="Catalytic domain of Insulin Receptor-like Protein
                     Tyrosine Kinases; cd05032"
                     /db_xref="CDD:173625"
     Site            order(702,704..706,710,728,730,777,779,783,832,836..837,
                     839,850,867..869,871..872,881,883,915)
                     /site_type="active"
                     /db_xref="CDD:173625"
     Site            order(702,704..706,710,728,730,777,779,783,837,839,850)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:173625"
     Site            order(832,836,867..869,871..872,881,883,915)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:173625"
     Site            849..874
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:173625"
     CDS             1..1064
                     /gene="IGF1R"
                     /gene_synonym="CD221; IGFIR; IGFR; JTK13"
                     /coded_by="XM_011521516.3:36806..40000"
                     /db_xref="GeneID:3480"
                     /db_xref="HGNC:HGNC:5465"
                     /db_xref="MIM:147370"
ORIGIN      
        1 mqecpsgfir ngsqsmycip cegpcpkvce eekktktids vtsaqmlqgc tifkgnllin
       61 irrgnniase lenfmgliev vtgyvkirhs halvslsflk nlrlilgeeq legnysfyvl
      121 dnqnlqqlwd wdhrnltika gkmyfafnpk lcvseiyrme evtgtkgrqs kgdintrnng
      181 erascesdvl hftstttskn riiitwhryr ppdyrdlisf tvyykeapfk nvteydgqda
      241 cgsnswnmvd vdlppnkdve pgillhglkp wtqyavyvka vtltmvendh irgakseily
      301 irtnasvpsi pldvlsasns ssqlivkwnp pslpngnlsy yivrwqrqpq dgylyrhnyc
      361 skdkipirky adgtidieev tenpktevcg gekgpccacp kteaekqaek eeaeyrkvfe
      421 nflhnsifvp rperkrrdvm qvanttmssr srnttaadty nitdpeelet eypffesrvd
      481 nkertvisnl rpftlyridi hscnheaekl gcsasnfvfa rtmpaegadd ipgpvtwepr
      541 pensiflkwp epenpnglil myeikygsqv edqrecvsrq eyrkyggakl nrlnpgnyta
      601 riqatslsgn gswtdpvffy vqaktgyenf ihliialpva vllivgglvi mlyvfhrkrn
      661 nsrlgngvly asvnpeyfsa advyvpdewe varekitmsr elgqgsfgmv yegvakgvvk
      721 depetrvaik tvneaasmre rieflneasv mkefnchhvv rllgvvsqgq ptlvimelmt
      781 rgdlksylrs lrpemennpv lappslskmi qmageiadgm aylnankfvh rdlaarncmv
      841 aedftvkigd fgmtrdiyet dyyrkggkgl lpvrwmspes lkdgvfttys dvwsfgvvlw
      901 eiatlaeqpy qglsneqvlr fvmegglldk pdncpdmlfe lmrmcwqynp kmrpsfleii
      961 ssikeemepg frevsfyyse enklpepeel dlepenmesv pldpsassss lplpdrhsgh
     1021 kaengpgpgv lvlrasfder qpyahmnggr kneralplpq sstc
//
LOCUS       XP_011519819             922 aa            linear   PRI 05-AUG-2025
DEFINITION  insulin-like growth factor 1 receptor isoform X7 [Homo sapiens].
ACCESSION   XP_011519819
VERSION     XP_011519819.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521517.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..922
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..922
                     /product="insulin-like growth factor 1 receptor isoform
                     X7"
                     /calculated_mol_wt=104600
     Region          49..161
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(150..151,153..154)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          166..>210
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Region          390..479
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(468..469,471..472)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          547..823
                     /region_name="PTKc_InsR_like"
                     /note="Catalytic domain of Insulin Receptor-like Protein
                     Tyrosine Kinases; cd05032"
                     /db_xref="CDD:173625"
     Site            order(560,562..564,568,586,588,635,637,641,690,694..695,
                     697,708,725..727,729..730,739,741,773)
                     /site_type="active"
                     /db_xref="CDD:173625"
     Site            order(560,562..564,568,586,588,635,637,641,695,697,708)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:173625"
     Site            order(690,694,725..727,729..730,739,741,773)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:173625"
     Site            707..732
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:173625"
     CDS             1..922
                     /gene="IGF1R"
                     /gene_synonym="CD221; IGFIR; IGFR; JTK13"
                     /coded_by="XM_011521517.3:913..3681"
                     /db_xref="GeneID:3480"
                     /db_xref="HGNC:HGNC:5465"
                     /db_xref="MIM:147370"
ORIGIN      
        1 myfafnpklc vseiyrmeev tgtkgrqskg dintrnnger ascesdvlhf tstttsknri
       61 iitwhryrpp dyrdlisftv yykeapfknv teydgqdacg snswnmvdvd lppnkdvepg
      121 illhglkpwt qyavyvkavt ltmvendhir gakseilyir tnasvpsipl dvlsasnsss
      181 qlivkwnpps lpngnlsyyi vrwqrqpqdg ylyrhnycsk dkipirkyad gtidieevte
      241 npktevcgge kgpccacpkt eaekqaekee aeyrkvfenf lhnsifvprp erkrrdvmqv
      301 anttmssrsr nttaadtyni tdpeeletey pffesrvdnk ertvisnlrp ftlyridihs
      361 cnheaeklgc sasnfvfart mpaegaddip gpvtweprpe nsiflkwpep enpnglilmy
      421 eikygsqved qrecvsrqey rkyggaklnr lnpgnytari qatslsgngs wtdpvffyvq
      481 aktgyenfih liialpvavl livgglviml yvfhrkrnns rlgngvlyas vnpeyfsaad
      541 vyvpdeweva rekitmsrel gqgsfgmvye gvakgvvkde petrvaiktv neaasmreri
      601 eflneasvmk efnchhvvrl lgvvsqgqpt lvimelmtrg dlksylrslr pemennpvla
      661 ppslskmiqm ageiadgmay lnankfvhrd laarncmvae dftvkigdfg mtrdiyetdy
      721 yrkggkgllp vrwmspeslk dgvfttysdv wsfgvvlwei atlaeqpyqg lsneqvlrfv
      781 megglldkpd ncpdmlfelm rmcwqynpkm rpsfleiiss ikeemepgfr evsfyyseen
      841 klpepeeldl epenmesvpl dpsasssslp lpdrhsghka engpgpgvlv lrasfderqp
      901 yahmnggrkn eralplpqss tc
//
LOCUS       XP_047288402             181 aa            linear   PRI 05-AUG-2025
DEFINITION  RNA-binding protein with multiple splicing 2 isoform X1 [Homo
            sapiens].
ACCESSION   XP_047288402
VERSION     XP_047288402.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432446.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..181
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..181
                     /product="RNA-binding protein with multiple splicing 2
                     isoform X1"
                     /calculated_mol_wt=19825
     Region          2..77
                     /region_name="RRM_RBPMS2"
                     /note="RNA recognition motif (RRM) found in vertebrate
                     RNA-binding protein with multiple splicing 2 (RBP-MS2);
                     cd12683"
                     /db_xref="CDD:410084"
     CDS             1..181
                     /gene="RBPMS2"
                     /coded_by="XM_047432446.1:16..561"
                     /db_xref="GeneID:348093"
                     /db_xref="HGNC:HGNC:19098"
                     /db_xref="MIM:619034"
ORIGIN      
        1 mvrtlfvsgl pvdikprely llfrpfkgye gslikltarq pvgfvifdsr agaeaaknal
       61 ngirfdpenp qtlrlefaka ntkmaksklm atpnpsnvhp algahfiard pydlmgaali
      121 paspeawapy plytteltpa ishaaftypt ataaaaalha qvrwypssdt tqqgwkyrqf
      181 c
//
LOCUS       XP_047288403            1396 aa            linear   PRI 05-AUG-2025
DEFINITION  pro-interleukin-16 isoform X1 [Homo sapiens].
ACCESSION   XP_047288403
VERSION     XP_047288403.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432447.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1396
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1396
                     /product="pro-interleukin-16 isoform X1"
                     /calculated_mol_wt=148872
     Region          279..364
                     /region_name="PDZ3_PDZD2-PDZ1_hPro-IL-16-like"
                     /note="PDZ domain 3 of PDZ domain containing 2 (PDZD2),
                     PDZ domain 1 of human pro-interleukin-16 (isoform 1, 1332
                     AA), and related domains; cd06759"
                     /db_xref="CDD:467240"
     Site            order(290..296,311,314,344,348,351..352)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467240"
     Region          414..503
                     /region_name="PDZ4_PDZD2-PDZ2_hPro-IL-16-like"
                     /note="PDZ domain 4 of PDZ domain containing 2 (PDZD2),
                     PDZ domain 2 of human pro-interleukin-16 (isoform 1, 1332
                     AA), and related domains; cd06760"
                     /db_xref="CDD:467241"
     Site            order(429..435,449,452,482,486,489..490)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467241"
     Region          1175..1260
                     /region_name="PDZ6_PDZD2-PDZ3_hPro-IL-16-like"
                     /note="PDZ domain 6 of PDZ domain containing 2 (PDZD2),
                     PDZ domain 3 of human pro-interleukin-16 (isoform 1, 1332
                     AA), and related domains; cd06762"
                     /db_xref="CDD:467243"
     Site            order(1187..1193,1206,1209,1239,1243,1246..1247)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467243"
     Region          1296..1381
                     /region_name="PDZ7_PDZD2-PDZ4_hPro-IL-16-like"
                     /note="PDZ domain 7 of PDZ domain containing 2 (PDZD2),
                     PDZ domain 4 of human pro-interleukin-16 (isoform 1, 1332
                     AA), and related domains; cd06763"
                     /db_xref="CDD:467244"
     Site            order(1307..1313,1328,1331,1361,1365,1368..1369)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467244"
     CDS             1..1396
                     /gene="IL16"
                     /gene_synonym="LCF; NIL16; prIL-16; PRIL16"
                     /coded_by="XM_047432447.1:146..4336"
                     /db_xref="GeneID:3603"
                     /db_xref="HGNC:HGNC:5980"
                     /db_xref="MIM:603035"
ORIGIN      
        1 mslqkrvfpr rqnegvwsta gemelregra gthevaakpc pvatrqprar dqerkkgsft
       61 sslrmeshsr agksrksakf rsisrslmlc naktsddgss pdekypdpfe islaqgkegi
      121 fhssvqladt seagpssvpd lalaseaaql qaagndrgkt crriffmkes stassrekpg
      181 kleaqssnfl fpkachqrar snstsvnpyc treidfpmtk ksaaptdrqp yslcsnrksl
      241 sqqldcpagk aagtsrptrs lstaqlvqps gglqasvisn ivlmkgqakg lgfsivggkd
      301 siygpigiyv ktifaggaaa adgrlqegde ilelngesma glthqdalqk fkqakkgllt
      361 ltvrtrltap pslcshlspp lcrslssstc itkdsssfal espsapista kpnyrimvev
      421 slqkeagvgl giglcsvpyf qcisgifvht lspgsvahld grlrcgdeiv eisdspvhcl
      481 tlnevytils hcdpgpvpii vsrhpdpqvs eqqlkeavaq aventkfgke rhqwslegvk
      541 rlesswhgrp tlekerekns apphrraqkv mirsssdssy msgspggspg sgsaekpssd
      601 vdisthspsl plarepvvls iassrlpqes pplpesrdsh pplrlkksfe ilvrkpmssk
      661 pkppprkyfk sdsdpqksle erensscssg htpptcgqea rellplllpq edtagrspsa
      721 sagcpgpgig pqtksstege pgwrraspvt qtspikhpll krqarmdysf dttaedpwvr
      781 isdciknlfs pimsenhghm plqpnaslne eegtqghpdg tppkldtang tpkvyksads
      841 stvkkgppva pkpawfrqsl kglrnrasdp rglpdpalst qpapasrehl gshirassss
      901 ssirqrissf etfgssqlpd kgaqrlslqp ssgeaakplg kheegrfsgl lgrgaaptlv
      961 pqqpeqvlss gspaaseard pgvsespppg rqpnqktlpp gpdpllrlls tqaeesqgpv
     1021 lkmpsqrars fpltrsqsce tklldektsk lysissqvss avmksllclp ssiscaqtpc
     1081 ipkegaspts ssnedsaang saetsaldtg fslnlselre yteglteake dddgdhsslq
     1141 sgqsvislls seelkkliee vkvldeatlk qldgihvtil hkeegaglgf slaggadlen
     1201 kvitvhrvfp nglasqegti qkgnevlsin gkslkgtthh dalailrqar eprqavivtr
     1261 kltpeampdl nsstdsaasa saasdvsves taeatvctvt lekmsaglgf sleggkgslh
     1321 gdkpltinri fkgaaseqse tvqpgdeilq lggtamqglt rfeawniika lpdgpvtivi
     1381 rrkslqsket taagds
//
LOCUS       XP_047288404            1395 aa            linear   PRI 05-AUG-2025
DEFINITION  pro-interleukin-16 isoform X2 [Homo sapiens].
ACCESSION   XP_047288404
VERSION     XP_047288404.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432448.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1395
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1395
                     /product="pro-interleukin-16 isoform X2"
                     /calculated_mol_wt=148801
     Region          279..364
                     /region_name="PDZ3_PDZD2-PDZ1_hPro-IL-16-like"
                     /note="PDZ domain 3 of PDZ domain containing 2 (PDZD2),
                     PDZ domain 1 of human pro-interleukin-16 (isoform 1, 1332
                     AA), and related domains; cd06759"
                     /db_xref="CDD:467240"
     Site            order(290..296,311,314,344,348,351..352)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467240"
     Region          414..503
                     /region_name="PDZ4_PDZD2-PDZ2_hPro-IL-16-like"
                     /note="PDZ domain 4 of PDZ domain containing 2 (PDZD2),
                     PDZ domain 2 of human pro-interleukin-16 (isoform 1, 1332
                     AA), and related domains; cd06760"
                     /db_xref="CDD:467241"
     Site            order(429..435,449,452,482,486,489..490)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467241"
     Region          1175..1260
                     /region_name="PDZ6_PDZD2-PDZ3_hPro-IL-16-like"
                     /note="PDZ domain 6 of PDZ domain containing 2 (PDZD2),
                     PDZ domain 3 of human pro-interleukin-16 (isoform 1, 1332
                     AA), and related domains; cd06762"
                     /db_xref="CDD:467243"
     Site            order(1187..1193,1206,1209,1239,1243,1246..1247)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467243"
     Region          1295..1380
                     /region_name="PDZ7_PDZD2-PDZ4_hPro-IL-16-like"
                     /note="PDZ domain 7 of PDZ domain containing 2 (PDZD2),
                     PDZ domain 4 of human pro-interleukin-16 (isoform 1, 1332
                     AA), and related domains; cd06763"
                     /db_xref="CDD:467244"
     Site            order(1306..1312,1327,1330,1360,1364,1367..1368)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467244"
     CDS             1..1395
                     /gene="IL16"
                     /gene_synonym="LCF; NIL16; prIL-16; PRIL16"
                     /coded_by="XM_047432448.1:146..4333"
                     /db_xref="GeneID:3603"
                     /db_xref="HGNC:HGNC:5980"
                     /db_xref="MIM:603035"
ORIGIN      
        1 mslqkrvfpr rqnegvwsta gemelregra gthevaakpc pvatrqprar dqerkkgsft
       61 sslrmeshsr agksrksakf rsisrslmlc naktsddgss pdekypdpfe islaqgkegi
      121 fhssvqladt seagpssvpd lalaseaaql qaagndrgkt crriffmkes stassrekpg
      181 kleaqssnfl fpkachqrar snstsvnpyc treidfpmtk ksaaptdrqp yslcsnrksl
      241 sqqldcpagk aagtsrptrs lstaqlvqps gglqasvisn ivlmkgqakg lgfsivggkd
      301 siygpigiyv ktifaggaaa adgrlqegde ilelngesma glthqdalqk fkqakkgllt
      361 ltvrtrltap pslcshlspp lcrslssstc itkdsssfal espsapista kpnyrimvev
      421 slqkeagvgl giglcsvpyf qcisgifvht lspgsvahld grlrcgdeiv eisdspvhcl
      481 tlnevytils hcdpgpvpii vsrhpdpqvs eqqlkeavaq aventkfgke rhqwslegvk
      541 rlesswhgrp tlekerekns apphrraqkv mirsssdssy msgspggspg sgsaekpssd
      601 vdisthspsl plarepvvls iassrlpqes pplpesrdsh pplrlkksfe ilvrkpmssk
      661 pkppprkyfk sdsdpqksle erensscssg htpptcgqea rellplllpq edtagrspsa
      721 sagcpgpgig pqtksstege pgwrraspvt qtspikhpll krqarmdysf dttaedpwvr
      781 isdciknlfs pimsenhghm plqpnaslne eegtqghpdg tppkldtang tpkvyksads
      841 stvkkgppva pkpawfrqsl kglrnrasdp rglpdpalst qpapasrehl gshirassss
      901 ssirqrissf etfgssqlpd kgaqrlslqp ssgeaakplg kheegrfsgl lgrgaaptlv
      961 pqqpeqvlss gspaaseard pgvsespppg rqpnqktlpp gpdpllrlls tqaeesqgpv
     1021 lkmpsqrars fpltrsqsce tklldektsk lysissqvss avmksllclp ssiscaqtpc
     1081 ipkegaspts ssnedsaang saetsaldtg fslnlselre yteglteake dddgdhsslq
     1141 sgqsvislls seelkkliee vkvldeatlk qldgihvtil hkeegaglgf slaggadlen
     1201 kvitvhrvfp nglasqegti qkgnevlsin gkslkgtthh dalailrqar eprqavivtr
     1261 kltpeampdl nsstdsaasa saasdvsves teatvctvtl ekmsaglgfs leggkgslhg
     1321 dkpltinrif kgaaseqset vqpgdeilql ggtamqgltr feawniikal pdgpvtivir
     1381 rkslqskett aagds
//
LOCUS       XP_047288406            1378 aa            linear   PRI 05-AUG-2025
DEFINITION  pro-interleukin-16 isoform X4 [Homo sapiens].
ACCESSION   XP_047288406
VERSION     XP_047288406.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432450.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1378
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1378
                     /product="pro-interleukin-16 isoform X4"
                     /calculated_mol_wt=146941
     Region          262..347
                     /region_name="PDZ3_PDZD2-PDZ1_hPro-IL-16-like"
                     /note="PDZ domain 3 of PDZ domain containing 2 (PDZD2),
                     PDZ domain 1 of human pro-interleukin-16 (isoform 1, 1332
                     AA), and related domains; cd06759"
                     /db_xref="CDD:467240"
     Site            order(273..279,294,297,327,331,334..335)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467240"
     Region          397..486
                     /region_name="PDZ4_PDZD2-PDZ2_hPro-IL-16-like"
                     /note="PDZ domain 4 of PDZ domain containing 2 (PDZD2),
                     PDZ domain 2 of human pro-interleukin-16 (isoform 1, 1332
                     AA), and related domains; cd06760"
                     /db_xref="CDD:467241"
     Site            order(412..418,432,435,465,469,472..473)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467241"
     Region          <907..1002
                     /region_name="PRK12438"
                     /note="hypothetical protein; Provisional"
                     /db_xref="CDD:171499"
     Region          1158..1243
                     /region_name="PDZ6_PDZD2-PDZ3_hPro-IL-16-like"
                     /note="PDZ domain 6 of PDZ domain containing 2 (PDZD2),
                     PDZ domain 3 of human pro-interleukin-16 (isoform 1, 1332
                     AA), and related domains; cd06762"
                     /db_xref="CDD:467243"
     Site            order(1170..1176,1189,1192,1222,1226,1229..1230)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467243"
     Region          1278..1363
                     /region_name="PDZ7_PDZD2-PDZ4_hPro-IL-16-like"
                     /note="PDZ domain 7 of PDZ domain containing 2 (PDZD2),
                     PDZ domain 4 of human pro-interleukin-16 (isoform 1, 1332
                     AA), and related domains; cd06763"
                     /db_xref="CDD:467244"
     Site            order(1289..1295,1310,1313,1343,1347,1350..1351)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467244"
     CDS             1..1378
                     /gene="IL16"
                     /gene_synonym="LCF; NIL16; prIL-16; PRIL16"
                     /coded_by="XM_047432450.1:146..4282"
                     /db_xref="GeneID:3603"
                     /db_xref="HGNC:HGNC:5980"
                     /db_xref="MIM:603035"
ORIGIN      
        1 mslqkrvfpr rqngthevaa kpcpvatrqp rardqerkkg sftsslrmes hsragksrks
       61 akfrsisrsl mlcnaktsdd gsspdekypd pfeislaqgk egifhssvql adtseagpss
      121 vpdlalasea aqlqaagndr gktcrriffm kesstassre kpgkleaqss nflfpkachq
      181 rarsnstsvn pyctreidfp mtkksaaptd rqpyslcsnr kslsqqldcp agkaagtsrp
      241 trslstaqlv qpsgglqasv isnivlmkgq akglgfsivg gkdsiygpig iyvktifagg
      301 aaaadgrlqe gdeilelnge smaglthqda lqkfkqakkg lltltvrtrl tappslcshl
      361 spplcrslss stcitkdsss falespsapi stakpnyrim vevslqkeag vglgiglcsv
      421 pyfqcisgif vhtlspgsva hldgrlrcgd eiveisdspv hcltlnevyt ilshcdpgpv
      481 piivsrhpdp qvseqqlkea vaqaventkf gkerhqwsle gvkrlesswh grptlekere
      541 knsapphrra qkvmirsssd ssymsgspgg spgsgsaekp ssdvdisths pslplarepv
      601 vlsiassrlp qespplpesr dshpplrlkk sfeilvrkpm sskpkppprk yfksdsdpqk
      661 sleerenssc ssghtpptcg qearellpll lpqedtagrs psasagcpgp gigpqtksst
      721 egepgwrras pvtqtspikh pllkrqarmd ysfdttaedp wvrisdcikn lfspimsenh
      781 ghmplqpnas lneeegtqgh pdgtppkldt angtpkvyks adsstvkkgp pvapkpawfr
      841 qslkglrnra sdprglpdpa lstqpapasr ehlgshiras sssssirqri ssfetfgssq
      901 lpdkgaqrls lqpssgeaak plgkheegrf sgllgrgaap tlvpqqpeqv lssgspaase
      961 ardpgvsesp ppgrqpnqkt lppgpdpllr llstqaeesq gpvlkmpsqr arsfpltrsq
     1021 scetklldek tsklysissq vssavmksll clpssiscaq tpcipkegas ptsssnedsa
     1081 angsaetsal dtgfslnlse lreyteglte akedddgdhs slqsgqsvis llsseelkkl
     1141 ieevkvldea tlkqldgihv tilhkeegag lgfslaggad lenkvitvhr vfpnglasqe
     1201 gtiqkgnevl singkslkgt thhdalailr qareprqavi vtrkltpeam pdlnsstdsa
     1261 asasaasdvs vesteatvct vtlekmsagl gfsleggkgs lhgdkpltin rifkgaaseq
     1321 setvqpgdei lqlggtamqg ltrfeawnii kalpdgpvti virrkslqsk ettaagds
//
LOCUS       XP_047288407            1335 aa            linear   PRI 05-AUG-2025
DEFINITION  pro-interleukin-16 isoform X5 [Homo sapiens].
ACCESSION   XP_047288407
VERSION     XP_047288407.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432451.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1335
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1335
                     /product="pro-interleukin-16 isoform X5"
                     /calculated_mol_wt=142462
     Region          279..364
                     /region_name="PDZ3_PDZD2-PDZ1_hPro-IL-16-like"
                     /note="PDZ domain 3 of PDZ domain containing 2 (PDZD2),
                     PDZ domain 1 of human pro-interleukin-16 (isoform 1, 1332
                     AA), and related domains; cd06759"
                     /db_xref="CDD:467240"
     Site            order(290..296,311,314,344,348,351..352)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467240"
     Region          414..503
                     /region_name="PDZ4_PDZD2-PDZ2_hPro-IL-16-like"
                     /note="PDZ domain 4 of PDZ domain containing 2 (PDZD2),
                     PDZ domain 2 of human pro-interleukin-16 (isoform 1, 1332
                     AA), and related domains; cd06760"
                     /db_xref="CDD:467241"
     Site            order(429..435,449,452,482,486,489..490)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467241"
     Region          <924..1019
                     /region_name="PRK12438"
                     /note="hypothetical protein; Provisional"
                     /db_xref="CDD:171499"
     Region          1175..1260
                     /region_name="PDZ6_PDZD2-PDZ3_hPro-IL-16-like"
                     /note="PDZ domain 6 of PDZ domain containing 2 (PDZD2),
                     PDZ domain 3 of human pro-interleukin-16 (isoform 1, 1332
                     AA), and related domains; cd06762"
                     /db_xref="CDD:467243"
     Site            order(1187..1193,1206,1209,1239,1243,1246..1247)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467243"
     Region          1296..>1332
                     /region_name="PDZ_canonical"
                     /note="canonical PDZ domain; cl49608"
                     /db_xref="CDD:483948"
     CDS             1..1335
                     /gene="IL16"
                     /gene_synonym="LCF; NIL16; prIL-16; PRIL16"
                     /coded_by="XM_047432451.1:146..4153"
                     /db_xref="GeneID:3603"
                     /db_xref="HGNC:HGNC:5980"
                     /db_xref="MIM:603035"
ORIGIN      
        1 mslqkrvfpr rqnegvwsta gemelregra gthevaakpc pvatrqprar dqerkkgsft
       61 sslrmeshsr agksrksakf rsisrslmlc naktsddgss pdekypdpfe islaqgkegi
      121 fhssvqladt seagpssvpd lalaseaaql qaagndrgkt crriffmkes stassrekpg
      181 kleaqssnfl fpkachqrar snstsvnpyc treidfpmtk ksaaptdrqp yslcsnrksl
      241 sqqldcpagk aagtsrptrs lstaqlvqps gglqasvisn ivlmkgqakg lgfsivggkd
      301 siygpigiyv ktifaggaaa adgrlqegde ilelngesma glthqdalqk fkqakkgllt
      361 ltvrtrltap pslcshlspp lcrslssstc itkdsssfal espsapista kpnyrimvev
      421 slqkeagvgl giglcsvpyf qcisgifvht lspgsvahld grlrcgdeiv eisdspvhcl
      481 tlnevytils hcdpgpvpii vsrhpdpqvs eqqlkeavaq aventkfgke rhqwslegvk
      541 rlesswhgrp tlekerekns apphrraqkv mirsssdssy msgspggspg sgsaekpssd
      601 vdisthspsl plarepvvls iassrlpqes pplpesrdsh pplrlkksfe ilvrkpmssk
      661 pkppprkyfk sdsdpqksle erensscssg htpptcgqea rellplllpq edtagrspsa
      721 sagcpgpgig pqtksstege pgwrraspvt qtspikhpll krqarmdysf dttaedpwvr
      781 isdciknlfs pimsenhghm plqpnaslne eegtqghpdg tppkldtang tpkvyksads
      841 stvkkgppva pkpawfrqsl kglrnrasdp rglpdpalst qpapasrehl gshirassss
      901 ssirqrissf etfgssqlpd kgaqrlslqp ssgeaakplg kheegrfsgl lgrgaaptlv
      961 pqqpeqvlss gspaaseard pgvsespppg rqpnqktlpp gpdpllrlls tqaeesqgpv
     1021 lkmpsqrars fpltrsqsce tklldektsk lysissqvss avmksllclp ssiscaqtpc
     1081 ipkegaspts ssnedsaang saetsaldtg fslnlselre yteglteake dddgdhsslq
     1141 sgqsvislls seelkkliee vkvldeatlk qldgihvtil hkeegaglgf slaggadlen
     1201 kvitvhrvfp nglasqegti qkgnevlsin gkslkgtthh dalailrqar eprqavivtr
     1261 kltpeampdl nsstdsaasa saasdvsves taeatvctvt lekmsaglgf sleggkgslh
     1321 gdkpltinri fkalk
//
LOCUS       XP_047288408            1334 aa            linear   PRI 05-AUG-2025
DEFINITION  pro-interleukin-16 isoform X6 [Homo sapiens].
ACCESSION   XP_047288408
VERSION     XP_047288408.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432452.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1334
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1334
                     /product="pro-interleukin-16 isoform X6"
                     /calculated_mol_wt=142391
     Region          279..364
                     /region_name="PDZ3_PDZD2-PDZ1_hPro-IL-16-like"
                     /note="PDZ domain 3 of PDZ domain containing 2 (PDZD2),
                     PDZ domain 1 of human pro-interleukin-16 (isoform 1, 1332
                     AA), and related domains; cd06759"
                     /db_xref="CDD:467240"
     Site            order(290..296,311,314,344,348,351..352)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467240"
     Region          414..503
                     /region_name="PDZ4_PDZD2-PDZ2_hPro-IL-16-like"
                     /note="PDZ domain 4 of PDZ domain containing 2 (PDZD2),
                     PDZ domain 2 of human pro-interleukin-16 (isoform 1, 1332
                     AA), and related domains; cd06760"
                     /db_xref="CDD:467241"
     Site            order(429..435,449,452,482,486,489..490)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467241"
     Region          <924..1019
                     /region_name="PRK12438"
                     /note="hypothetical protein; Provisional"
                     /db_xref="CDD:171499"
     Region          1175..1260
                     /region_name="PDZ6_PDZD2-PDZ3_hPro-IL-16-like"
                     /note="PDZ domain 6 of PDZ domain containing 2 (PDZD2),
                     PDZ domain 3 of human pro-interleukin-16 (isoform 1, 1332
                     AA), and related domains; cd06762"
                     /db_xref="CDD:467243"
     Site            order(1187..1193,1206,1209,1239,1243,1246..1247)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467243"
     Region          1295..>1331
                     /region_name="PDZ_canonical"
                     /note="canonical PDZ domain; cl49608"
                     /db_xref="CDD:483948"
     CDS             1..1334
                     /gene="IL16"
                     /gene_synonym="LCF; NIL16; prIL-16; PRIL16"
                     /coded_by="XM_047432452.1:146..4150"
                     /db_xref="GeneID:3603"
                     /db_xref="HGNC:HGNC:5980"
                     /db_xref="MIM:603035"
ORIGIN      
        1 mslqkrvfpr rqnegvwsta gemelregra gthevaakpc pvatrqprar dqerkkgsft
       61 sslrmeshsr agksrksakf rsisrslmlc naktsddgss pdekypdpfe islaqgkegi
      121 fhssvqladt seagpssvpd lalaseaaql qaagndrgkt crriffmkes stassrekpg
      181 kleaqssnfl fpkachqrar snstsvnpyc treidfpmtk ksaaptdrqp yslcsnrksl
      241 sqqldcpagk aagtsrptrs lstaqlvqps gglqasvisn ivlmkgqakg lgfsivggkd
      301 siygpigiyv ktifaggaaa adgrlqegde ilelngesma glthqdalqk fkqakkgllt
      361 ltvrtrltap pslcshlspp lcrslssstc itkdsssfal espsapista kpnyrimvev
      421 slqkeagvgl giglcsvpyf qcisgifvht lspgsvahld grlrcgdeiv eisdspvhcl
      481 tlnevytils hcdpgpvpii vsrhpdpqvs eqqlkeavaq aventkfgke rhqwslegvk
      541 rlesswhgrp tlekerekns apphrraqkv mirsssdssy msgspggspg sgsaekpssd
      601 vdisthspsl plarepvvls iassrlpqes pplpesrdsh pplrlkksfe ilvrkpmssk
      661 pkppprkyfk sdsdpqksle erensscssg htpptcgqea rellplllpq edtagrspsa
      721 sagcpgpgig pqtksstege pgwrraspvt qtspikhpll krqarmdysf dttaedpwvr
      781 isdciknlfs pimsenhghm plqpnaslne eegtqghpdg tppkldtang tpkvyksads
      841 stvkkgppva pkpawfrqsl kglrnrasdp rglpdpalst qpapasrehl gshirassss
      901 ssirqrissf etfgssqlpd kgaqrlslqp ssgeaakplg kheegrfsgl lgrgaaptlv
      961 pqqpeqvlss gspaaseard pgvsespppg rqpnqktlpp gpdpllrlls tqaeesqgpv
     1021 lkmpsqrars fpltrsqsce tklldektsk lysissqvss avmksllclp ssiscaqtpc
     1081 ipkegaspts ssnedsaang saetsaldtg fslnlselre yteglteake dddgdhsslq
     1141 sgqsvislls seelkkliee vkvldeatlk qldgihvtil hkeegaglgf slaggadlen
     1201 kvitvhrvfp nglasqegti qkgnevlsin gkslkgtthh dalailrqar eprqavivtr
     1261 kltpeampdl nsstdsaasa saasdvsves teatvctvtl ekmsaglgfs leggkgslhg
     1321 dkpltinrif kalk
//
LOCUS       XP_047288409            1332 aa            linear   PRI 05-AUG-2025
DEFINITION  pro-interleukin-16 isoform X7 [Homo sapiens].
ACCESSION   XP_047288409
VERSION     XP_047288409.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432453.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1332
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1332
                     /product="pro-interleukin-16 isoform X7"
                     /calculated_mol_wt=141622
     Region          215..300
                     /region_name="PDZ3_PDZD2-PDZ1_hPro-IL-16-like"
                     /note="PDZ domain 3 of PDZ domain containing 2 (PDZD2),
                     PDZ domain 1 of human pro-interleukin-16 (isoform 1, 1332
                     AA), and related domains; cd06759"
                     /db_xref="CDD:467240"
     Site            order(226..232,247,250,280,284,287..288)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467240"
     Region          350..439
                     /region_name="PDZ4_PDZD2-PDZ2_hPro-IL-16-like"
                     /note="PDZ domain 4 of PDZ domain containing 2 (PDZD2),
                     PDZ domain 2 of human pro-interleukin-16 (isoform 1, 1332
                     AA), and related domains; cd06760"
                     /db_xref="CDD:467241"
     Site            order(365..371,385,388,418,422,425..426)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467241"
     Region          <860..955
                     /region_name="PRK12438"
                     /note="hypothetical protein; Provisional"
                     /db_xref="CDD:171499"
     Region          1111..1196
                     /region_name="PDZ6_PDZD2-PDZ3_hPro-IL-16-like"
                     /note="PDZ domain 6 of PDZ domain containing 2 (PDZD2),
                     PDZ domain 3 of human pro-interleukin-16 (isoform 1, 1332
                     AA), and related domains; cd06762"
                     /db_xref="CDD:467243"
     Site            order(1123..1129,1142,1145,1175,1179,1182..1183)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467243"
     Region          1232..1317
                     /region_name="PDZ7_PDZD2-PDZ4_hPro-IL-16-like"
                     /note="PDZ domain 7 of PDZ domain containing 2 (PDZD2),
                     PDZ domain 4 of human pro-interleukin-16 (isoform 1, 1332
                     AA), and related domains; cd06763"
                     /db_xref="CDD:467244"
     Site            order(1243..1249,1264,1267,1297,1301,1304..1305)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467244"
     CDS             1..1332
                     /gene="IL16"
                     /gene_synonym="LCF; NIL16; prIL-16; PRIL16"
                     /coded_by="XM_047432453.1:172..4170"
                     /db_xref="GeneID:3603"
                     /db_xref="HGNC:HGNC:5980"
                     /db_xref="MIM:603035"
ORIGIN      
        1 meshsragks rksakfrsis rslmlcnakt sddgsspdek ypdpfeisla qgkegifhss
       61 vqladtseag pssvpdlala seaaqlqaag ndrgktcrri ffmkesstas srekpgklea
      121 qssnflfpka chqrarsnst svnpyctrei dfpmtkksaa ptdrqpyslc snrkslsqql
      181 dcpagkaagt srptrslsta qlvqpsgglq asvisnivlm kgqakglgfs ivggkdsiyg
      241 pigiyvktif aggaaaadgr lqegdeilel ngesmaglth qdalqkfkqa kkglltltvr
      301 trltappslc shlspplcrs lssstcitkd sssfalesps apistakpny rimvevslqk
      361 eagvglgigl csvpyfqcis gifvhtlspg svahldgrlr cgdeiveisd spvhcltlne
      421 vytilshcdp gpvpiivsrh pdpqvseqql keavaqaven tkfgkerhqw slegvkrles
      481 swhgrptlek ereknsapph rraqkvmirs ssdssymsgs pggspgsgsa ekpssdvdis
      541 thspslplar epvvlsiass rlpqespplp esrdshpplr lkksfeilvr kpmsskpkpp
      601 prkyfksdsd pqksleeren sscssghtpp tcgqearell plllpqedta grspsasagc
      661 pgpgigpqtk sstegepgwr raspvtqtsp ikhpllkrqa rmdysfdtta edpwvrisdc
      721 iknlfspims enhghmplqp naslneeegt qghpdgtppk ldtangtpkv yksadsstvk
      781 kgppvapkpa wfrqslkglr nrasdprglp dpalstqpap asrehlgshi rassssssir
      841 qrissfetfg ssqlpdkgaq rlslqpssge aakplgkhee grfsgllgrg aaptlvpqqp
      901 eqvlssgspa aseardpgvs espppgrqpn qktlppgpdp llrllstqae esqgpvlkmp
      961 sqrarsfplt rsqscetkll dektsklysi ssqvssavmk sllclpssis caqtpcipke
     1021 gasptsssne dsaangsaet saldtgfsln lselreyteg lteakedddg dhsslqsgqs
     1081 visllsseel kklieevkvl deatlkqldg ihvtilhkee gaglgfslag gadlenkvit
     1141 vhrvfpngla sqegtiqkgn evlsingksl kgtthhdala ilrqareprq avivtrkltp
     1201 eampdlnsst dsaasasaas dvsvestaea tvctvtlekm saglgfsleg gkgslhgdkp
     1261 ltinrifkga aseqsetvqp gdeilqlggt amqgltrfea wniikalpdg pvtivirrks
     1321 lqskettaag ds
//
LOCUS       XP_047288410            1162 aa            linear   PRI 05-AUG-2025
DEFINITION  pro-interleukin-16 isoform X8 [Homo sapiens].
ACCESSION   XP_047288410
VERSION     XP_047288410.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432454.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1162
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1162
                     /product="pro-interleukin-16 isoform X8"
                     /calculated_mol_wt=123261
     Region          45..130
                     /region_name="PDZ3_PDZD2-PDZ1_hPro-IL-16-like"
                     /note="PDZ domain 3 of PDZ domain containing 2 (PDZD2),
                     PDZ domain 1 of human pro-interleukin-16 (isoform 1, 1332
                     AA), and related domains; cd06759"
                     /db_xref="CDD:467240"
     Site            order(56..62,77,80,110,114,117..118)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467240"
     Region          180..269
                     /region_name="PDZ4_PDZD2-PDZ2_hPro-IL-16-like"
                     /note="PDZ domain 4 of PDZ domain containing 2 (PDZD2),
                     PDZ domain 2 of human pro-interleukin-16 (isoform 1, 1332
                     AA), and related domains; cd06760"
                     /db_xref="CDD:467241"
     Site            order(195..201,215,218,248,252,255..256)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467241"
     Region          <690..785
                     /region_name="PRK12438"
                     /note="hypothetical protein; Provisional"
                     /db_xref="CDD:171499"
     Region          941..1026
                     /region_name="PDZ6_PDZD2-PDZ3_hPro-IL-16-like"
                     /note="PDZ domain 6 of PDZ domain containing 2 (PDZD2),
                     PDZ domain 3 of human pro-interleukin-16 (isoform 1, 1332
                     AA), and related domains; cd06762"
                     /db_xref="CDD:467243"
     Site            order(953..959,972,975,1005,1009,1012..1013)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467243"
     Region          1062..1147
                     /region_name="PDZ7_PDZD2-PDZ4_hPro-IL-16-like"
                     /note="PDZ domain 7 of PDZ domain containing 2 (PDZD2),
                     PDZ domain 4 of human pro-interleukin-16 (isoform 1, 1332
                     AA), and related domains; cd06763"
                     /db_xref="CDD:467244"
     Site            order(1073..1079,1094,1097,1127,1131,1134..1135)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467244"
     CDS             1..1162
                     /gene="IL16"
                     /gene_synonym="LCF; NIL16; prIL-16; PRIL16"
                     /coded_by="XM_047432454.1:56..3544"
                     /db_xref="GeneID:3603"
                     /db_xref="HGNC:HGNC:5980"
                     /db_xref="MIM:603035"
ORIGIN      
        1 mpirkqlhss hsahpaclgt srptrslsta qlvqpsgglq asvisnivlm kgqakglgfs
       61 ivggkdsiyg pigiyvktif aggaaaadgr lqegdeilel ngesmaglth qdalqkfkqa
      121 kkglltltvr trltappslc shlspplcrs lssstcitkd sssfalesps apistakpny
      181 rimvevslqk eagvglgigl csvpyfqcis gifvhtlspg svahldgrlr cgdeiveisd
      241 spvhcltlne vytilshcdp gpvpiivsrh pdpqvseqql keavaqaven tkfgkerhqw
      301 slegvkrles swhgrptlek ereknsapph rraqkvmirs ssdssymsgs pggspgsgsa
      361 ekpssdvdis thspslplar epvvlsiass rlpqespplp esrdshpplr lkksfeilvr
      421 kpmsskpkpp prkyfksdsd pqksleeren sscssghtpp tcgqearell plllpqedta
      481 grspsasagc pgpgigpqtk sstegepgwr raspvtqtsp ikhpllkrqa rmdysfdtta
      541 edpwvrisdc iknlfspims enhghmplqp naslneeegt qghpdgtppk ldtangtpkv
      601 yksadsstvk kgppvapkpa wfrqslkglr nrasdprglp dpalstqpap asrehlgshi
      661 rassssssir qrissfetfg ssqlpdkgaq rlslqpssge aakplgkhee grfsgllgrg
      721 aaptlvpqqp eqvlssgspa aseardpgvs espppgrqpn qktlppgpdp llrllstqae
      781 esqgpvlkmp sqrarsfplt rsqscetkll dektsklysi ssqvssavmk sllclpssis
      841 caqtpcipke gasptsssne dsaangsaet saldtgfsln lselreyteg lteakedddg
      901 dhsslqsgqs visllsseel kklieevkvl deatlkqldg ihvtilhkee gaglgfslag
      961 gadlenkvit vhrvfpngla sqegtiqkgn evlsingksl kgtthhdala ilrqareprq
     1021 avivtrkltp eampdlnsst dsaasasaas dvsvestaea tvctvtlekm saglgfsleg
     1081 gkgslhgdkp ltinrifkga aseqsetvqp gdeilqlggt amqgltrfea wniikalpdg
     1141 pvtivirrks lqskettaag ds
//
LOCUS       XP_047288411             762 aa            linear   PRI 05-AUG-2025
DEFINITION  pro-interleukin-16 isoform X9 [Homo sapiens].
ACCESSION   XP_047288411
VERSION     XP_047288411.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432455.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..762
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..762
                     /product="pro-interleukin-16 isoform X9"
                     /calculated_mol_wt=82065
     Region          279..364
                     /region_name="PDZ3_PDZD2-PDZ1_hPro-IL-16-like"
                     /note="PDZ domain 3 of PDZ domain containing 2 (PDZD2),
                     PDZ domain 1 of human pro-interleukin-16 (isoform 1, 1332
                     AA), and related domains; cd06759"
                     /db_xref="CDD:467240"
     Site            order(290..296,311,314,344,348,351..352)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467240"
     Region          414..503
                     /region_name="PDZ4_PDZD2-PDZ2_hPro-IL-16-like"
                     /note="PDZ domain 4 of PDZ domain containing 2 (PDZD2),
                     PDZ domain 2 of human pro-interleukin-16 (isoform 1, 1332
                     AA), and related domains; cd06760"
                     /db_xref="CDD:467241"
     Site            order(429..435,449,452,482,486,489..490)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467241"
     CDS             1..762
                     /gene="IL16"
                     /gene_synonym="LCF; NIL16; prIL-16; PRIL16"
                     /coded_by="XM_047432455.1:146..2434"
                     /db_xref="GeneID:3603"
                     /db_xref="HGNC:HGNC:5980"
                     /db_xref="MIM:603035"
ORIGIN      
        1 mslqkrvfpr rqnegvwsta gemelregra gthevaakpc pvatrqprar dqerkkgsft
       61 sslrmeshsr agksrksakf rsisrslmlc naktsddgss pdekypdpfe islaqgkegi
      121 fhssvqladt seagpssvpd lalaseaaql qaagndrgkt crriffmkes stassrekpg
      181 kleaqssnfl fpkachqrar snstsvnpyc treidfpmtk ksaaptdrqp yslcsnrksl
      241 sqqldcpagk aagtsrptrs lstaqlvqps gglqasvisn ivlmkgqakg lgfsivggkd
      301 siygpigiyv ktifaggaaa adgrlqegde ilelngesma glthqdalqk fkqakkgllt
      361 ltvrtrltap pslcshlspp lcrslssstc itkdsssfal espsapista kpnyrimvev
      421 slqkeagvgl giglcsvpyf qcisgifvht lspgsvahld grlrcgdeiv eisdspvhcl
      481 tlnevytils hcdpgpvpii vsrhpdpqvs eqqlkeavaq aventkfgke rhqwslegvk
      541 rlesswhgrp tlekerekns apphrraqkv mirsssdssy msgspggspg sgsaekpssd
      601 vdisthspsl plarepvvls iassrlpqes pplpesrdsh pplrlkksfe ilvrkpmssk
      661 pkppprkyfk sdsdpqksle erensscssg htpptcgqea rellplllpq edtagrspsa
      721 sagcpgpgig pqtksstege pgwrraspaw klefrkkshc mm
//
LOCUS       XP_047288412             722 aa            linear   PRI 05-AUG-2025
DEFINITION  pro-interleukin-16 isoform X10 [Homo sapiens].
ACCESSION   XP_047288412
VERSION     XP_047288412.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432456.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..722
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..722
                     /product="pro-interleukin-16 isoform X10"
                     /calculated_mol_wt=76453
     Region          <250..345
                     /region_name="PRK12438"
                     /note="hypothetical protein; Provisional"
                     /db_xref="CDD:171499"
     Region          501..586
                     /region_name="PDZ6_PDZD2-PDZ3_hPro-IL-16-like"
                     /note="PDZ domain 6 of PDZ domain containing 2 (PDZD2),
                     PDZ domain 3 of human pro-interleukin-16 (isoform 1, 1332
                     AA), and related domains; cd06762"
                     /db_xref="CDD:467243"
     Site            order(513..519,532,535,565,569,572..573)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467243"
     Region          622..707
                     /region_name="PDZ7_PDZD2-PDZ4_hPro-IL-16-like"
                     /note="PDZ domain 7 of PDZ domain containing 2 (PDZD2),
                     PDZ domain 4 of human pro-interleukin-16 (isoform 1, 1332
                     AA), and related domains; cd06763"
                     /db_xref="CDD:467244"
     Site            order(633..639,654,657,687,691,694..695)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467244"
     CDS             1..722
                     /gene="IL16"
                     /gene_synonym="LCF; NIL16; prIL-16; PRIL16"
                     /coded_by="XM_047432456.1:432..2600"
                     /db_xref="GeneID:3603"
                     /db_xref="HGNC:HGNC:5980"
                     /db_xref="MIM:603035"
ORIGIN      
        1 mwlpvkelti hecqqmstyr apnqearell plllpqedta grspsasagc pgpgigpqtk
       61 sstegepgwr raspvtqtsp ikhpllkrqa rmdysfdtta edpwvrisdc iknlfspims
      121 enhghmplqp naslneeegt qghpdgtppk ldtangtpkv yksadsstvk kgppvapkpa
      181 wfrqslkglr nrasdprglp dpalstqpap asrehlgshi rassssssir qrissfetfg
      241 ssqlpdkgaq rlslqpssge aakplgkhee grfsgllgrg aaptlvpqqp eqvlssgspa
      301 aseardpgvs espppgrqpn qktlppgpdp llrllstqae esqgpvlkmp sqrarsfplt
      361 rsqscetkll dektsklysi ssqvssavmk sllclpssis caqtpcipke gasptsssne
      421 dsaangsaet saldtgfsln lselreyteg lteakedddg dhsslqsgqs visllsseel
      481 kklieevkvl deatlkqldg ihvtilhkee gaglgfslag gadlenkvit vhrvfpngla
      541 sqegtiqkgn evlsingksl kgtthhdala ilrqareprq avivtrkltp eampdlnsst
      601 dsaasasaas dvsvestaea tvctvtlekm saglgfsleg gkgslhgdkp ltinrifkga
      661 aseqsetvqp gdeilqlggt amqgltrfea wniikalpdg pvtivirrks lqskettaag
      721 ds
//
LOCUS       XP_047288413             721 aa            linear   PRI 05-AUG-2025
DEFINITION  pro-interleukin-16 isoform X11 [Homo sapiens].
ACCESSION   XP_047288413
VERSION     XP_047288413.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432457.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..721
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..721
                     /product="pro-interleukin-16 isoform X11"
                     /calculated_mol_wt=76382
     Region          <250..345
                     /region_name="PRK12438"
                     /note="hypothetical protein; Provisional"
                     /db_xref="CDD:171499"
     Region          501..586
                     /region_name="PDZ6_PDZD2-PDZ3_hPro-IL-16-like"
                     /note="PDZ domain 6 of PDZ domain containing 2 (PDZD2),
                     PDZ domain 3 of human pro-interleukin-16 (isoform 1, 1332
                     AA), and related domains; cd06762"
                     /db_xref="CDD:467243"
     Site            order(513..519,532,535,565,569,572..573)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467243"
     Region          621..706
                     /region_name="PDZ7_PDZD2-PDZ4_hPro-IL-16-like"
                     /note="PDZ domain 7 of PDZ domain containing 2 (PDZD2),
                     PDZ domain 4 of human pro-interleukin-16 (isoform 1, 1332
                     AA), and related domains; cd06763"
                     /db_xref="CDD:467244"
     Site            order(632..638,653,656,686,690,693..694)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467244"
     CDS             1..721
                     /gene="IL16"
                     /gene_synonym="LCF; NIL16; prIL-16; PRIL16"
                     /coded_by="XM_047432457.1:432..2597"
                     /db_xref="GeneID:3603"
                     /db_xref="HGNC:HGNC:5980"
                     /db_xref="MIM:603035"
ORIGIN      
        1 mwlpvkelti hecqqmstyr apnqearell plllpqedta grspsasagc pgpgigpqtk
       61 sstegepgwr raspvtqtsp ikhpllkrqa rmdysfdtta edpwvrisdc iknlfspims
      121 enhghmplqp naslneeegt qghpdgtppk ldtangtpkv yksadsstvk kgppvapkpa
      181 wfrqslkglr nrasdprglp dpalstqpap asrehlgshi rassssssir qrissfetfg
      241 ssqlpdkgaq rlslqpssge aakplgkhee grfsgllgrg aaptlvpqqp eqvlssgspa
      301 aseardpgvs espppgrqpn qktlppgpdp llrllstqae esqgpvlkmp sqrarsfplt
      361 rsqscetkll dektsklysi ssqvssavmk sllclpssis caqtpcipke gasptsssne
      421 dsaangsaet saldtgfsln lselreyteg lteakedddg dhsslqsgqs visllsseel
      481 kklieevkvl deatlkqldg ihvtilhkee gaglgfslag gadlenkvit vhrvfpngla
      541 sqegtiqkgn evlsingksl kgtthhdala ilrqareprq avivtrkltp eampdlnsst
      601 dsaasasaas dvsvesteat vctvtlekms aglgfslegg kgslhgdkpl tinrifkgaa
      661 seqsetvqpg deilqlggta mqgltrfeaw niikalpdgp vtivirrksl qskettaagd
      721 s
//
LOCUS       XP_047288414             714 aa            linear   PRI 05-AUG-2025
DEFINITION  pro-interleukin-16 isoform X12 [Homo sapiens].
ACCESSION   XP_047288414
VERSION     XP_047288414.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432458.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..714
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..714
                     /product="pro-interleukin-16 isoform X12"
                     /calculated_mol_wt=77160
     Region          279..364
                     /region_name="PDZ3_PDZD2-PDZ1_hPro-IL-16-like"
                     /note="PDZ domain 3 of PDZ domain containing 2 (PDZD2),
                     PDZ domain 1 of human pro-interleukin-16 (isoform 1, 1332
                     AA), and related domains; cd06759"
                     /db_xref="CDD:467240"
     Site            order(290..296,311,314,344,348,351..352)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467240"
     Region          414..503
                     /region_name="PDZ4_PDZD2-PDZ2_hPro-IL-16-like"
                     /note="PDZ domain 4 of PDZ domain containing 2 (PDZD2),
                     PDZ domain 2 of human pro-interleukin-16 (isoform 1, 1332
                     AA), and related domains; cd06760"
                     /db_xref="CDD:467241"
     Site            order(429..435,449,452,482,486,489..490)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467241"
     CDS             1..714
                     /gene="IL16"
                     /gene_synonym="LCF; NIL16; prIL-16; PRIL16"
                     /coded_by="XM_047432458.1:146..2290"
                     /db_xref="GeneID:3603"
                     /db_xref="HGNC:HGNC:5980"
                     /db_xref="MIM:603035"
ORIGIN      
        1 mslqkrvfpr rqnegvwsta gemelregra gthevaakpc pvatrqprar dqerkkgsft
       61 sslrmeshsr agksrksakf rsisrslmlc naktsddgss pdekypdpfe islaqgkegi
      121 fhssvqladt seagpssvpd lalaseaaql qaagndrgkt crriffmkes stassrekpg
      181 kleaqssnfl fpkachqrar snstsvnpyc treidfpmtk ksaaptdrqp yslcsnrksl
      241 sqqldcpagk aagtsrptrs lstaqlvqps gglqasvisn ivlmkgqakg lgfsivggkd
      301 siygpigiyv ktifaggaaa adgrlqegde ilelngesma glthqdalqk fkqakkgllt
      361 ltvrtrltap pslcshlspp lcrslssstc itkdsssfal espsapista kpnyrimvev
      421 slqkeagvgl giglcsvpyf qcisgifvht lspgsvahld grlrcgdeiv eisdspvhcl
      481 tlnevytils hcdpgpvpii vsrhpdpqvs eqqlkeavaq aventkfgke rhqwslegvk
      541 rlesswhgrp tlekerekns apphrraqkv mirsssdssy msgspggspg sgsaekpssd
      601 vdisthspsl plarepvvls iassrlpqes pplpesrdsh pplrlkksfe ilvrkpmssk
      661 pkppprkyfk sdsdpqksle erensscssg htpptcgqgl ilkspmkrmq ywmc
//
LOCUS       XP_047288415             289 aa            linear   PRI 05-AUG-2025
DEFINITION  inositol-trisphosphate 3-kinase A isoform X1 [Homo sapiens].
ACCESSION   XP_047288415
VERSION     XP_047288415.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432459.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..289
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..289
                     /product="inositol-trisphosphate 3-kinase A isoform X1"
                     /calculated_mol_wt=32943
     Region          73..283
                     /region_name="IPK"
                     /note="Inositol polyphosphate kinase; pfam03770"
                     /db_xref="CDD:397715"
     CDS             1..289
                     /gene="ITPKA"
                     /gene_synonym="IP3-3KA; IP3KA"
                     /coded_by="XM_047432459.1:3230..4099"
                     /db_xref="GeneID:3706"
                     /db_xref="HGNC:HGNC:6178"
                     /db_xref="MIM:147521"
ORIGIN      
        1 mvnlpvispf kkryawvqla ghtgsfkaag tsglilkrcs eperyclarl madalrgcvp
       61 afhgvverdg esylqlqdll dgfdgpcvld ckmgvrtyle eeltkarerp klrkdmykkm
      121 lavdpeapte eehaqravtk prymqwregi sssttlgfri egikkadgsc stdfkttrsr
      181 eqvlrvfeef vqgdeevlrr ylnrlqqird tlevseffrr hevigssllf vhdhchragv
      241 wlidfgkttp lpdgqildhr rpweegnred gyllgldnli gilaslaer
//
LOCUS       XP_016877638             516 aa            linear   PRI 05-AUG-2025
DEFINITION  isovaleryl-CoA dehydrogenase, mitochondrial isoform X1 [Homo
            sapiens].
ACCESSION   XP_016877638
VERSION     XP_016877638.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022149.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..516
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..516
                     /product="isovaleryl-CoA dehydrogenase, mitochondrial
                     isoform X1"
                     /calculated_mol_wt=56329
     Region          44..412
                     /region_name="IVD"
                     /note="Isovaleryl-CoA dehydrogenase; cd01156"
                     /db_xref="CDD:173845"
     Site            315
                     /site_type="active"
                     /note="catalytic base [active]"
                     /db_xref="CDD:173845"
     CDS             1..516
                     /gene="IVD"
                     /gene_synonym="ACAD2; IVDH"
                     /coded_by="XM_017022149.2:25..1575"
                     /db_xref="GeneID:3712"
                     /db_xref="HGNC:HGNC:6186"
                     /db_xref="MIM:607036"
ORIGIN      
        1 maematatrl lgwrvaswrl rpplagfvsq rahsllpvdd ainglseeqr qlrqtmakfl
       61 qehlapkaqe idrsnefknl rvswevravg gsqgvglsct aawksshsfl efwkqlgnlg
      121 vlgitapvqy ggsglgyleh vlvmeeisra sgavglsyga hsnlcinqlv rngneaqkek
      181 ylpklisgey igalamsepn agsdvvsmkl kaekkgnhyi lngnkfwitn gpdadvlivy
      241 aktdlaavpa srgitafive kgmpgfstsk kldklgmrgs ntcelifedc kipaanilgh
      301 enkgvyvlms gldlerlvla ggplglmqav ldhtipylhv reafgqkigh fqlmqgkmad
      361 mytrlmacrq yvynvakacd eghctakdca gvilysaeca tqvaldgiqc fgqtfsaqhp
      421 pgregetrgq tsleqvstar elrckillpe ltprvllpql aswisdqklp flkillcspt
      481 slgqsslagf tklrwpypll qphllphpyt talhlc
//
LOCUS       XP_047288416             497 aa            linear   PRI 05-AUG-2025
DEFINITION  isovaleryl-CoA dehydrogenase, mitochondrial isoform X2 [Homo
            sapiens].
ACCESSION   XP_047288416
VERSION     XP_047288416.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432460.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..497
                     /product="isovaleryl-CoA dehydrogenase, mitochondrial
                     isoform X2"
                     /calculated_mol_wt=54419
     Region          26..393
                     /region_name="IVD"
                     /note="Isovaleryl-CoA dehydrogenase; cd01156"
                     /db_xref="CDD:173845"
     Site            296
                     /site_type="active"
                     /note="catalytic base [active]"
                     /db_xref="CDD:173845"
     CDS             1..497
                     /gene="IVD"
                     /gene_synonym="ACAD2; IVDH"
                     /coded_by="XM_047432460.1:461..1954"
                     /db_xref="GeneID:3712"
                     /db_xref="HGNC:HGNC:6186"
                     /db_xref="MIM:607036"
ORIGIN      
        1 mvfwwrigqa tyrlwhkgpq svcssltpeq aelrqtmakf lqehlapkaq eidrsnefkn
       61 lrvswevrav ggsqgvglsc taawksshsf lefwkqlgnl gvlgitapvq yggsglgyle
      121 hvlvmeeisr asgavglsyg ahsnlcinql vrngneaqke kylpklisge yigalamsep
      181 nagsdvvsmk lkaekkgnhy ilngnkfwit ngpdadvliv yaktdlaavp asrgitafiv
      241 ekgmpgfsts kkldklgmrg sntcelifed ckipaanilg henkgvyvlm sgldlerlvl
      301 aggplglmqa vldhtipylh vreafgqkig hfqlmqgkma dmytrlmacr qyvynvakac
      361 deghctakdc agvilysaec atqvaldgiq cfgqtfsaqh ppgregetrg qtsleqvsta
      421 relrckillp eltprvllpq laswisdqkl pflkillcsp tslgqsslag ftklrwpypl
      481 lqphllphpy ttalhlc
//
LOCUS       XP_047288417             468 aa            linear   PRI 05-AUG-2025
DEFINITION  isovaleryl-CoA dehydrogenase, mitochondrial isoform X3 [Homo
            sapiens].
ACCESSION   XP_047288417
VERSION     XP_047288417.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432461.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..468
                     /product="isovaleryl-CoA dehydrogenase, mitochondrial
                     isoform X3"
                     /calculated_mol_wt=51430
     Region          26..364
                     /region_name="IVD"
                     /note="Isovaleryl-CoA dehydrogenase; cd01156"
                     /db_xref="CDD:173845"
     Site            267
                     /site_type="active"
                     /note="catalytic base [active]"
                     /db_xref="CDD:173845"
     CDS             1..468
                     /gene="IVD"
                     /gene_synonym="ACAD2; IVDH"
                     /coded_by="XM_047432461.1:461..1867"
                     /db_xref="GeneID:3712"
                     /db_xref="HGNC:HGNC:6186"
                     /db_xref="MIM:607036"
ORIGIN      
        1 mvfwwrigqa tyrlwhkgpq svcssltpeq aelrqtmakf lqehlapkaq eidrsnefkn
       61 lrefwkqlgn lgvlgitapv qyggsglgyl ehvlvmeeis rasgavglsy gahsnlcinq
      121 lvrngneaqk ekylpklisg eyigalamse pnagsdvvsm klkaekkgnh yilngnkfwi
      181 tngpdadvli vyaktdlaav pasrgitafi vekgmpgfst skkldklgmr gsntcelife
      241 dckipaanil ghenkgvyvl msgldlerlv laggplglmq avldhtipyl hvreafgqki
      301 ghfqlmqgkm admytrlmac rqyvynvaka cdeghctakd cagvilysae catqvaldgi
      361 qcfgqtfsaq hppgregetr gqtsleqvst arelrckill peltprvllp qlaswisdqk
      421 lpflkillcs ptslgqssla gftklrwpyp llqphllphp yttalhlc
//
LOCUS       XP_016877642             447 aa            linear   PRI 05-AUG-2025
DEFINITION  isovaleryl-CoA dehydrogenase, mitochondrial isoform X4 [Homo
            sapiens].
ACCESSION   XP_016877642
VERSION     XP_016877642.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022153.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..447
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..447
                     /product="isovaleryl-CoA dehydrogenase, mitochondrial
                     isoform X4"
                     /calculated_mol_wt=48516
     Region          44..411
                     /region_name="IVD"
                     /note="Isovaleryl-CoA dehydrogenase; cd01156"
                     /db_xref="CDD:173845"
     Site            315
                     /site_type="active"
                     /note="catalytic base [active]"
                     /db_xref="CDD:173845"
     CDS             1..447
                     /gene="IVD"
                     /gene_synonym="ACAD2; IVDH"
                     /coded_by="XM_017022153.2:25..1368"
                     /db_xref="GeneID:3712"
                     /db_xref="HGNC:HGNC:6186"
                     /db_xref="MIM:607036"
ORIGIN      
        1 maematatrl lgwrvaswrl rpplagfvsq rahsllpvdd ainglseeqr qlrqtmakfl
       61 qehlapkaqe idrsnefknl rvswevravg gsqgvglsct aawksshsfl efwkqlgnlg
      121 vlgitapvqy ggsglgyleh vlvmeeisra sgavglsyga hsnlcinqlv rngneaqkek
      181 ylpklisgey igalamsepn agsdvvsmkl kaekkgnhyi lngnkfwitn gpdadvlivy
      241 aktdlaavpa srgitafive kgmpgfstsk kldklgmrgs ntcelifedc kipaanilgh
      301 enkgvyvlms gldlerlvla ggplglmqav ldhtipylhv reafgqkigh fqlmqgkmad
      361 mytrlmacrq yvynvakacd eghctakdca gvilysaeca tqvaldgiqc fdlfrptptw
      421 eggrdprsdv pgagehcegt emqdppa
//
LOCUS       XP_016877643             436 aa            linear   PRI 05-AUG-2025
DEFINITION  isovaleryl-CoA dehydrogenase, mitochondrial isoform X5 [Homo
            sapiens].
ACCESSION   XP_016877643
VERSION     XP_016877643.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022154.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..436
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..436
                     /product="isovaleryl-CoA dehydrogenase, mitochondrial
                     isoform X5"
                     /calculated_mol_wt=47599
     Region          26..433
                     /region_name="IVD"
                     /note="Isovaleryl-CoA dehydrogenase; cd01156"
                     /db_xref="CDD:173845"
     Site            order(137,141,145,184,210,233,287,294,297,300,412..413,
                     416..418)
                     /site_type="other"
                     /note="substrate binding site [chemical binding]"
                     /db_xref="CDD:173845"
     Site            order(175,177..178,183..184,208,210,419,421)
                     /site_type="other"
                     /note="FAD binding site [chemical binding]"
                     /db_xref="CDD:173845"
     Site            296
                     /site_type="active"
                     /note="catalytic base [active]"
                     /db_xref="CDD:173845"
     CDS             1..436
                     /gene="IVD"
                     /gene_synonym="ACAD2; IVDH"
                     /coded_by="XM_017022154.3:461..1771"
                     /db_xref="GeneID:3712"
                     /db_xref="HGNC:HGNC:6186"
                     /db_xref="MIM:607036"
ORIGIN      
        1 mvfwwrigqa tyrlwhkgpq svcssltpeq aelrqtmakf lqehlapkaq eidrsnefkn
       61 lrvswevrav ggsqgvglsc taawksshsf lefwkqlgnl gvlgitapvq yggsglgyle
      121 hvlvmeeisr asgavglsyg ahsnlcinql vrngneaqke kylpklisge yigalamsep
      181 nagsdvvsmk lkaekkgnhy ilngnkfwit ngpdadvliv yaktdlaavp asrgitafiv
      241 ekgmpgfsts kkldklgmrg sntcelifed ckipaanilg henkgvyvlm sgldlerlvl
      301 aggplglmqa vldhtipylh vreafgqkig hfqlmqgkma dmytrlmacr qyvynvakac
      361 deghctakdc agvilysaec atqvaldgiq cfggngyind fpmgrflrda klyeigagts
      421 evrrlvigra fnadfh
//
LOCUS       XP_016877644             418 aa            linear   PRI 05-AUG-2025
DEFINITION  isovaleryl-CoA dehydrogenase, mitochondrial isoform X6 [Homo
            sapiens].
ACCESSION   XP_016877644
VERSION     XP_016877644.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022155.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..418
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..418
                     /product="isovaleryl-CoA dehydrogenase, mitochondrial
                     isoform X6"
                     /calculated_mol_wt=45311
     Region          44..411
                     /region_name="IVD"
                     /note="Isovaleryl-CoA dehydrogenase; cd01156"
                     /db_xref="CDD:173845"
     Site            315
                     /site_type="active"
                     /note="catalytic base [active]"
                     /db_xref="CDD:173845"
     CDS             1..418
                     /gene="IVD"
                     /gene_synonym="ACAD2; IVDH"
                     /coded_by="XM_017022155.3:25..1281"
                     /db_xref="GeneID:3712"
                     /db_xref="HGNC:HGNC:6186"
                     /db_xref="MIM:607036"
ORIGIN      
        1 maematatrl lgwrvaswrl rpplagfvsq rahsllpvdd ainglseeqr qlrqtmakfl
       61 qehlapkaqe idrsnefknl rvswevravg gsqgvglsct aawksshsfl efwkqlgnlg
      121 vlgitapvqy ggsglgyleh vlvmeeisra sgavglsyga hsnlcinqlv rngneaqkek
      181 ylpklisgey igalamsepn agsdvvsmkl kaekkgnhyi lngnkfwitn gpdadvlivy
      241 aktdlaavpa srgitafive kgmpgfstsk kldklgmrgs ntcelifedc kipaanilgh
      301 enkgvyvlms gldlerlvla ggplglmqav ldhtipylhv reafgqkigh fqlmqgkmad
      361 mytrlmacrq yvynvakacd eghctakdca gvilysaeca tqvaldgiqc fvsrgiss
//
LOCUS       XP_047288418             418 aa            linear   PRI 05-AUG-2025
DEFINITION  isovaleryl-CoA dehydrogenase, mitochondrial isoform X7 [Homo
            sapiens].
ACCESSION   XP_047288418
VERSION     XP_047288418.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432462.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..418
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..418
                     /product="isovaleryl-CoA dehydrogenase, mitochondrial
                     isoform X7"
                     /calculated_mol_wt=45527
     Region          44..382
                     /region_name="IVD"
                     /note="Isovaleryl-CoA dehydrogenase; cd01156"
                     /db_xref="CDD:173845"
     Site            286
                     /site_type="active"
                     /note="catalytic base [active]"
                     /db_xref="CDD:173845"
     CDS             1..418
                     /gene="IVD"
                     /gene_synonym="ACAD2; IVDH"
                     /coded_by="XM_047432462.1:25..1281"
                     /db_xref="GeneID:3712"
                     /db_xref="HGNC:HGNC:6186"
                     /db_xref="MIM:607036"
ORIGIN      
        1 maematatrl lgwrvaswrl rpplagfvsq rahsllpvdd ainglseeqr qlrqtmakfl
       61 qehlapkaqe idrsnefknl refwkqlgnl gvlgitapvq yggsglgyle hvlvmeeisr
      121 asgavglsyg ahsnlcinql vrngneaqke kylpklisge yigalamsep nagsdvvsmk
      181 lkaekkgnhy ilngnkfwit ngpdadvliv yaktdlaavp asrgitafiv ekgmpgfsts
      241 kkldklgmrg sntcelifed ckipaanilg henkgvyvlm sgldlerlvl aggplglmqa
      301 vldhtipylh vreafgqkig hfqlmqgkma dmytrlmacr qyvynvakac deghctakdc
      361 agvilysaec atqvaldgiq cfdlfrptpt weggrdprsd vpgagehceg temqdppa
//
LOCUS       XP_047288419             389 aa            linear   PRI 05-AUG-2025
DEFINITION  isovaleryl-CoA dehydrogenase, mitochondrial isoform X8 [Homo
            sapiens].
ACCESSION   XP_047288419
VERSION     XP_047288419.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432463.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..389
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..389
                     /product="isovaleryl-CoA dehydrogenase, mitochondrial
                     isoform X8"
                     /calculated_mol_wt=42322
     Region          44..382
                     /region_name="IVD"
                     /note="Isovaleryl-CoA dehydrogenase; cd01156"
                     /db_xref="CDD:173845"
     Site            286
                     /site_type="active"
                     /note="catalytic base [active]"
                     /db_xref="CDD:173845"
     CDS             1..389
                     /gene="IVD"
                     /gene_synonym="ACAD2; IVDH"
                     /coded_by="XM_047432463.1:25..1194"
                     /db_xref="GeneID:3712"
                     /db_xref="HGNC:HGNC:6186"
                     /db_xref="MIM:607036"
ORIGIN      
        1 maematatrl lgwrvaswrl rpplagfvsq rahsllpvdd ainglseeqr qlrqtmakfl
       61 qehlapkaqe idrsnefknl refwkqlgnl gvlgitapvq yggsglgyle hvlvmeeisr
      121 asgavglsyg ahsnlcinql vrngneaqke kylpklisge yigalamsep nagsdvvsmk
      181 lkaekkgnhy ilngnkfwit ngpdadvliv yaktdlaavp asrgitafiv ekgmpgfsts
      241 kkldklgmrg sntcelifed ckipaanilg henkgvyvlm sgldlerlvl aggplglmqa
      301 vldhtipylh vreafgqkig hfqlmqgkma dmytrlmacr qyvynvakac deghctakdc
      361 agvilysaec atqvaldgiq cfvsrgiss
//
LOCUS       XP_016877646             376 aa            linear   PRI 05-AUG-2025
DEFINITION  isovaleryl-CoA dehydrogenase, mitochondrial isoform X9 [Homo
            sapiens].
ACCESSION   XP_016877646
VERSION     XP_016877646.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022157.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..376
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..376
                     /product="isovaleryl-CoA dehydrogenase, mitochondrial
                     isoform X9"
                     /calculated_mol_wt=40947
     Region          44..>352
                     /region_name="ACAD"
                     /note="Acyl-CoA dehydrogenase; cl09933"
                     /db_xref="CDD:447864"
     CDS             1..376
                     /gene="IVD"
                     /gene_synonym="ACAD2; IVDH"
                     /coded_by="XM_017022157.2:25..1155"
                     /db_xref="GeneID:3712"
                     /db_xref="HGNC:HGNC:6186"
                     /db_xref="MIM:607036"
ORIGIN      
        1 maematatrl lgwrvaswrl rpplagfvsq rahsllpvdd ainglseeqr qlrqtmakfl
       61 qehlapkaqe idrsnefknl rvswevravg gsqgvglsct aawksshsfl efwkqlgnlg
      121 vlgitapvqy ggsglgyleh vlvmeeisra sgavglsyga hsnlcinqlv rngneaqkek
      181 ylpklisgey igalamsepn agsdvvsmkl kaekkgnhyi lngnkfwitn gpdadvlivy
      241 aktdlaavpa srgitafive kgmpgfstsk kldklgmrgs ntcelifedc kipaanilgh
      301 enkgvyvlms gldlerlvla ggplglmqav ldhtipylhv reafgqkigh fqgrpfppnt
      361 hlggrarpev rrpwsr
//
LOCUS       XP_047288420             370 aa            linear   PRI 05-AUG-2025
DEFINITION  isovaleryl-CoA dehydrogenase, mitochondrial isoform X10 [Homo
            sapiens].
ACCESSION   XP_047288420
VERSION     XP_047288420.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432464.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..370
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..370
                     /product="isovaleryl-CoA dehydrogenase, mitochondrial
                     isoform X10"
                     /calculated_mol_wt=40412
     Region          26..363
                     /region_name="IVD"
                     /note="Isovaleryl-CoA dehydrogenase; cd01156"
                     /db_xref="CDD:173845"
     Site            267
                     /site_type="active"
                     /note="catalytic base [active]"
                     /db_xref="CDD:173845"
     CDS             1..370
                     /gene="IVD"
                     /gene_synonym="ACAD2; IVDH"
                     /coded_by="XM_047432464.1:461..1573"
                     /db_xref="GeneID:3712"
                     /db_xref="HGNC:HGNC:6186"
                     /db_xref="MIM:607036"
ORIGIN      
        1 mvfwwrigqa tyrlwhkgpq svcssltpeq aelrqtmakf lqehlapkaq eidrsnefkn
       61 lrefwkqlgn lgvlgitapv qyggsglgyl ehvlvmeeis rasgavglsy gahsnlcinq
      121 lvrngneaqk ekylpklisg eyigalamse pnagsdvvsm klkaekkgnh yilngnkfwi
      181 tngpdadvli vyaktdlaav pasrgitafi vekgmpgfst skkldklgmr gsntcelife
      241 dckipaanil ghenkgvyvl msgldlerlv laggplglmq avldhtipyl hvreafgqki
      301 ghfqlmqgkm admytrlmac rqyvynvaka cdeghctakd cagvilysae catqvaldgi
      361 qcfvsrgiss
//
LOCUS       XP_006720558             347 aa            linear   PRI 05-AUG-2025
DEFINITION  isovaleryl-CoA dehydrogenase, mitochondrial isoform X11 [Homo
            sapiens].
ACCESSION   XP_006720558
VERSION     XP_006720558.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720495.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..347
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..347
                     /product="isovaleryl-CoA dehydrogenase, mitochondrial
                     isoform X11"
                     /calculated_mol_wt=37958
     Region          44..>323
                     /region_name="ACAD"
                     /note="Acyl-CoA dehydrogenase; cl09933"
                     /db_xref="CDD:447864"
     CDS             1..347
                     /gene="IVD"
                     /gene_synonym="ACAD2; IVDH"
                     /coded_by="XM_006720495.4:25..1068"
                     /db_xref="GeneID:3712"
                     /db_xref="HGNC:HGNC:6186"
                     /db_xref="MIM:607036"
ORIGIN      
        1 maematatrl lgwrvaswrl rpplagfvsq rahsllpvdd ainglseeqr qlrqtmakfl
       61 qehlapkaqe idrsnefknl refwkqlgnl gvlgitapvq yggsglgyle hvlvmeeisr
      121 asgavglsyg ahsnlcinql vrngneaqke kylpklisge yigalamsep nagsdvvsmk
      181 lkaekkgnhy ilngnkfwit ngpdadvliv yaktdlaavp asrgitafiv ekgmpgfsts
      241 kkldklgmrg sntcelifed ckipaanilg henkgvyvlm sgldlerlvl aggplglmqa
      301 vldhtipylh vreafgqkig hfqgrpfppn thlggrarpe vrrpwsr
//
LOCUS       XP_016877647             308 aa            linear   PRI 05-AUG-2025
DEFINITION  isovaleryl-CoA dehydrogenase, mitochondrial isoform X12 [Homo
            sapiens].
ACCESSION   XP_016877647
VERSION     XP_016877647.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022158.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..308
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..308
                     /product="isovaleryl-CoA dehydrogenase, mitochondrial
                     isoform X12"
                     /calculated_mol_wt=33524
     Region          44..>293
                     /region_name="ACAD"
                     /note="Acyl-CoA dehydrogenase; cl09933"
                     /db_xref="CDD:447864"
     CDS             1..308
                     /gene="IVD"
                     /gene_synonym="ACAD2; IVDH"
                     /coded_by="XM_017022158.3:25..951"
                     /db_xref="GeneID:3712"
                     /db_xref="HGNC:HGNC:6186"
                     /db_xref="MIM:607036"
ORIGIN      
        1 maematatrl lgwrvaswrl rpplagfvsq rahsllpvdd ainglseeqr qlrqtmakfl
       61 qehlapkaqe idrsnefknl rvswevravg gsqgvglsct aawksshsfl efwkqlgnlg
      121 vlgitapvqy ggsglgyleh vlvmeeisra sgavglsyga hsnlcinqlv rngneaqkek
      181 ylpklisgey igalamsepn agsdvvsmkl kaekkgnhyi lngnkfwitn gpdadvlivy
      241 aktdlaavpa srgitafive kgmpgfstsk kldklgmrgs ntcelifedc kipvplikvr
      301 rlwtalsl
//
LOCUS       XP_047288421             301 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin carboxyl-terminal hydrolase 50 isoform X1 [Homo sapiens].
ACCESSION   XP_047288421
VERSION     XP_047288421.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432465.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..301
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..301
                     /product="ubiquitin carboxyl-terminal hydrolase 50 isoform
                     X1"
                     /calculated_mol_wt=34778
     Region          32..300
                     /region_name="UCH"
                     /note="Ubiquitin carboxyl-terminal hydrolase; pfam00443"
                     /db_xref="CDD:425685"
     CDS             1..301
                     /gene="USP50"
                     /coded_by="XM_047432465.1:217..1122"
                     /db_xref="GeneID:373509"
                     /db_xref="HGNC:HGNC:20079"
                     /db_xref="MIM:620563"
ORIGIN      
        1 mwhqhsaect dyydtlpvke adgnqphfqg vtglwnlgnt ccvnaisqcl csilplveyf
       61 ltgkyitalq ndcsevataf aylmtdmwlg dsdcvspeif wsalgnlypa ftkkmqqdaq
      121 eflicvlnel healkkyhys rrrsyekgst qrccrkwitt etsiitqlfe eqlnysivcl
      181 kcekctykne vftvfslpip skyecslrdc lqcffqqdal twnneihcsf cetkqetavr
      241 asiskapkii ifhlkrfdiq gttkrklrtd ihypltnldl tpyicsifrk ypkynlcavv
      301 d
//
LOCUS       XP_011519832             391 aa            linear   PRI 05-AUG-2025
DEFINITION  testis-expressed protein 9 isoform X1 [Homo sapiens].
ACCESSION   XP_011519832
VERSION     XP_011519832.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521530.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..391
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..391
                     /product="testis-expressed protein 9 isoform X1"
                     /calculated_mol_wt=44695
     Region          <190..>348
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..391
                     /gene="TEX9"
                     /coded_by="XM_011521530.4:26..1201"
                     /db_xref="GeneID:374618"
                     /db_xref="HGNC:HGNC:29585"
                     /db_xref="MIM:620935"
ORIGIN      
        1 magrslcltr ssvpgtpfpp pvqqpstpgp dllaleeeyk rlnaelqakt advvqqakei
       61 irdrqevrsr pvstqmkscd deddyslrgl lpsegivhlh setkpktkni dpvnkvqnkl
      121 hsankgrktn ssvklkysdv qtaddvaipe dfsdfslakt iskiegqlee eglpeyiddi
      181 fsgvsndigt eaqirflkak lhvmqeeldn vvcecnkked eiqnlksqvk nfeedfmrqq
      241 rtinmqqsqv ekyktlfeea nkkydglqqq lssverelen krrlqkqaas sqsatevrln
      301 raleeaekyk lelsklrqnn kdianeehkk ievlksenkk lekqkgelmi gfkkqlklid
      361 vlkrqkmhie aakmlsftee efmkalewgn s
//
LOCUS       XP_005254416             391 aa            linear   PRI 05-AUG-2025
DEFINITION  testis-expressed protein 9 isoform X1 [Homo sapiens].
ACCESSION   XP_005254416
VERSION     XP_005254416.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254359.6
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..391
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..391
                     /product="testis-expressed protein 9 isoform X1"
                     /calculated_mol_wt=44695
     Region          <190..>348
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..391
                     /gene="TEX9"
                     /coded_by="XM_005254359.6:26..1201"
                     /db_xref="GeneID:374618"
                     /db_xref="HGNC:HGNC:29585"
                     /db_xref="MIM:620935"
ORIGIN      
        1 magrslcltr ssvpgtpfpp pvqqpstpgp dllaleeeyk rlnaelqakt advvqqakei
       61 irdrqevrsr pvstqmkscd deddyslrgl lpsegivhlh setkpktkni dpvnkvqnkl
      121 hsankgrktn ssvklkysdv qtaddvaipe dfsdfslakt iskiegqlee eglpeyiddi
      181 fsgvsndigt eaqirflkak lhvmqeeldn vvcecnkked eiqnlksqvk nfeedfmrqq
      241 rtinmqqsqv ekyktlfeea nkkydglqqq lssverelen krrlqkqaas sqsatevrln
      301 raleeaekyk lelsklrqnn kdianeehkk ievlksenkk lekqkgelmi gfkkqlklid
      361 vlkrqkmhie aakmlsftee efmkalewgn s
//
LOCUS       XP_047288422             391 aa            linear   PRI 05-AUG-2025
DEFINITION  testis-expressed protein 9 isoform X1 [Homo sapiens].
ACCESSION   XP_047288422
VERSION     XP_047288422.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432466.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..391
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..391
                     /product="testis-expressed protein 9 isoform X1"
                     /calculated_mol_wt=44695
     Region          <190..>348
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..391
                     /gene="TEX9"
                     /coded_by="XM_047432466.1:26..1201"
                     /db_xref="GeneID:374618"
                     /db_xref="HGNC:HGNC:29585"
                     /db_xref="MIM:620935"
ORIGIN      
        1 magrslcltr ssvpgtpfpp pvqqpstpgp dllaleeeyk rlnaelqakt advvqqakei
       61 irdrqevrsr pvstqmkscd deddyslrgl lpsegivhlh setkpktkni dpvnkvqnkl
      121 hsankgrktn ssvklkysdv qtaddvaipe dfsdfslakt iskiegqlee eglpeyiddi
      181 fsgvsndigt eaqirflkak lhvmqeeldn vvcecnkked eiqnlksqvk nfeedfmrqq
      241 rtinmqqsqv ekyktlfeea nkkydglqqq lssverelen krrlqkqaas sqsatevrln
      301 raleeaekyk lelsklrqnn kdianeehkk ievlksenkk lekqkgelmi gfkkqlklid
      361 vlkrqkmhie aakmlsftee efmkalewgn s
//
LOCUS       XP_047288423             346 aa            linear   PRI 05-AUG-2025
DEFINITION  testis-expressed protein 9 isoform X2 [Homo sapiens].
ACCESSION   XP_047288423
VERSION     XP_047288423.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432467.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..346
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..346
                     /product="testis-expressed protein 9 isoform X2"
                     /calculated_mol_wt=39365
     Region          <190..>328
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..346
                     /gene="TEX9"
                     /coded_by="XM_047432467.1:26..1066"
                     /db_xref="GeneID:374618"
                     /db_xref="HGNC:HGNC:29585"
                     /db_xref="MIM:620935"
ORIGIN      
        1 magrslcltr ssvpgtpfpp pvqqpstpgp dllaleeeyk rlnaelqakt advvqqakei
       61 irdrqevrsr pvstqmkscd deddyslrgl lpsegivhlh setkpktkni dpvnkvqnkl
      121 hsankgrktn ssvklkysdv qtaddvaipe dfsdfslakt iskiegqlee eglpeyiddi
      181 fsgvsndigt eaqirflkak lhvmqeeldn vvcecnkked eiqnlksqvk nfeedfmrqq
      241 rtinmqqsqv ekyktlfeea nkkydglqqq lssverelen krrlqkqaas sqsatevrln
      301 raleeaekyk lelsklrqnn kmhieaakml sfteeefmka lewgns
//
LOCUS       XP_047288424             346 aa            linear   PRI 05-AUG-2025
DEFINITION  testis-expressed protein 9 isoform X2 [Homo sapiens].
ACCESSION   XP_047288424
VERSION     XP_047288424.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432468.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..346
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..346
                     /product="testis-expressed protein 9 isoform X2"
                     /calculated_mol_wt=39365
     Region          <190..>328
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..346
                     /gene="TEX9"
                     /coded_by="XM_047432468.1:26..1066"
                     /db_xref="GeneID:374618"
                     /db_xref="HGNC:HGNC:29585"
                     /db_xref="MIM:620935"
ORIGIN      
        1 magrslcltr ssvpgtpfpp pvqqpstpgp dllaleeeyk rlnaelqakt advvqqakei
       61 irdrqevrsr pvstqmkscd deddyslrgl lpsegivhlh setkpktkni dpvnkvqnkl
      121 hsankgrktn ssvklkysdv qtaddvaipe dfsdfslakt iskiegqlee eglpeyiddi
      181 fsgvsndigt eaqirflkak lhvmqeeldn vvcecnkked eiqnlksqvk nfeedfmrqq
      241 rtinmqqsqv ekyktlfeea nkkydglqqq lssverelen krrlqkqaas sqsatevrln
      301 raleeaekyk lelsklrqnn kmhieaakml sfteeefmka lewgns
//
LOCUS       XP_047288425             316 aa            linear   PRI 05-AUG-2025
DEFINITION  testis-expressed protein 9 isoform X3 [Homo sapiens].
ACCESSION   XP_047288425
VERSION     XP_047288425.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432469.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..316
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..316
                     /product="testis-expressed protein 9 isoform X3"
                     /calculated_mol_wt=36428
     Region          <115..>273
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..316
                     /gene="TEX9"
                     /coded_by="XM_047432469.1:152..1102"
                     /db_xref="GeneID:374618"
                     /db_xref="HGNC:HGNC:29585"
                     /db_xref="MIM:620935"
ORIGIN      
        1 mkscddeddy slrgllpseg ivhlhsetkp ktknidpvnk vqnklhsank grktnssvkl
       61 kysdvqtadd vaipedfsdf slaktiskie gqleeeglpe yiddifsgvs ndigteaqir
      121 flkaklhvmq eeldnvvcec nkkedeiqnl ksqvknfeed fmrqqrtinm qqsqvekykt
      181 lfeeankkyd glqqqlssve relenkrrlq kqaassqsat evrlnralee aekyklelsk
      241 lrqnnkdian eehkkievlk senkklekqk gelmigfkkq lklidvlkrq kmhieaakml
      301 sfteeefmka lewgns
//
LOCUS       XP_047288426             188 aa            linear   PRI 05-AUG-2025
DEFINITION  testis-expressed protein 9 isoform X4 [Homo sapiens].
ACCESSION   XP_047288426
VERSION     XP_047288426.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432470.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..188
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..188
                     /product="testis-expressed protein 9 isoform X4"
                     /calculated_mol_wt=22213
     Region          <2..>145
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..188
                     /gene="TEX9"
                     /coded_by="XM_047432470.1:870..1436"
                     /db_xref="GeneID:374618"
                     /db_xref="HGNC:HGNC:29585"
                     /db_xref="MIM:620935"
ORIGIN      
        1 mqeeldnvvc ecnkkedeiq nlksqvknfe edfmrqqrti nmqqsqveky ktlfeeankk
       61 ydglqqqlss verelenkrr lqkqaassqs atevrlnral eeaekyklel sklrqnnkdi
      121 aneehkkiev lksenkklek qkgelmigfk kqlklidvlk rqkmhieaak mlsfteeefm
      181 kalewgns
//
LOCUS       XP_047288427             188 aa            linear   PRI 05-AUG-2025
DEFINITION  testis-expressed protein 9 isoform X4 [Homo sapiens].
ACCESSION   XP_047288427
VERSION     XP_047288427.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432471.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 1% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..188
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..188
                     /product="testis-expressed protein 9 isoform X4"
                     /calculated_mol_wt=22213
     Region          <2..>145
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..188
                     /gene="TEX9"
                     /coded_by="XM_047432471.1:598..1164"
                     /db_xref="GeneID:374618"
                     /db_xref="HGNC:HGNC:29585"
                     /db_xref="MIM:620935"
ORIGIN      
        1 mqeeldnvvc ecnkkedeiq nlksqvknfe edfmrqqrti nmqqsqveky ktlfeeankk
       61 ydglqqqlss verelenkrr lqkqaassqs atevrlnral eeaekyklel sklrqnnkdi
      121 aneehkkiev lksenkklek qkgelmigfk kqlklidvlk rqkmhieaak mlsfteeefm
      181 kalewgns
//
LOCUS       XP_047288428             188 aa            linear   PRI 05-AUG-2025
DEFINITION  testis-expressed protein 9 isoform X4 [Homo sapiens].
ACCESSION   XP_047288428
VERSION     XP_047288428.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432472.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..188
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..188
                     /product="testis-expressed protein 9 isoform X4"
                     /calculated_mol_wt=22213
     Region          <2..>145
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..188
                     /gene="TEX9"
                     /coded_by="XM_047432472.1:324..890"
                     /db_xref="GeneID:374618"
                     /db_xref="HGNC:HGNC:29585"
                     /db_xref="MIM:620935"
ORIGIN      
        1 mqeeldnvvc ecnkkedeiq nlksqvknfe edfmrqqrti nmqqsqveky ktlfeeankk
       61 ydglqqqlss verelenkrr lqkqaassqs atevrlnral eeaekyklel sklrqnnkdi
      121 aneehkkiev lksenkklek qkgelmigfk kqlklidvlk rqkmhieaak mlsfteeefm
      181 kalewgns
//
LOCUS       XP_047288429             188 aa            linear   PRI 05-AUG-2025
DEFINITION  testis-expressed protein 9 isoform X4 [Homo sapiens].
ACCESSION   XP_047288429
VERSION     XP_047288429.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432473.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 1% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..188
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..188
                     /product="testis-expressed protein 9 isoform X4"
                     /calculated_mol_wt=22213
     Region          <2..>145
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..188
                     /gene="TEX9"
                     /coded_by="XM_047432473.1:119..685"
                     /db_xref="GeneID:374618"
                     /db_xref="HGNC:HGNC:29585"
                     /db_xref="MIM:620935"
ORIGIN      
        1 mqeeldnvvc ecnkkedeiq nlksqvknfe edfmrqqrti nmqqsqveky ktlfeeankk
       61 ydglqqqlss verelenkrr lqkqaassqs atevrlnral eeaekyklel sklrqnnkdi
      121 aneehkkiev lksenkklek qkgelmigfk kqlklidvlk rqkmhieaak mlsfteeefm
      181 kalewgns
//
LOCUS       XP_047288430             176 aa            linear   PRI 05-AUG-2025
DEFINITION  testis-expressed protein 9 isoform X5 [Homo sapiens].
ACCESSION   XP_047288430
VERSION     XP_047288430.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432474.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..176
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..176
                     /product="testis-expressed protein 9 isoform X5"
                     /calculated_mol_wt=19981
     Region          <32..>158
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     CDS             1..176
                     /gene="TEX9"
                     /coded_by="XM_047432474.1:26..556"
                     /db_xref="GeneID:374618"
                     /db_xref="HGNC:HGNC:29585"
                     /db_xref="MIM:620935"
ORIGIN      
        1 magrslcltr ssvpgtpfpp pvqqpstpgp dllaleeeyk rlnaelqakt advvqqakei
       61 ielenkrrlq kqaassqsat evrlnralee aekyklelsk lrqnnkdian eehkkievlk
      121 senkklekqk gelmigfkkq lklidvlkrq kmhieaakml sfteeefmka lewgns
//
LOCUS       XP_047288431             176 aa            linear   PRI 05-AUG-2025
DEFINITION  testis-expressed protein 9 isoform X5 [Homo sapiens].
ACCESSION   XP_047288431
VERSION     XP_047288431.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432475.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..176
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..176
                     /product="testis-expressed protein 9 isoform X5"
                     /calculated_mol_wt=19981
     Region          <32..>158
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     CDS             1..176
                     /gene="TEX9"
                     /coded_by="XM_047432475.1:26..556"
                     /db_xref="GeneID:374618"
                     /db_xref="HGNC:HGNC:29585"
                     /db_xref="MIM:620935"
ORIGIN      
        1 magrslcltr ssvpgtpfpp pvqqpstpgp dllaleeeyk rlnaelqakt advvqqakei
       61 ielenkrrlq kqaassqsat evrlnralee aekyklelsk lrqnnkdian eehkkievlk
      121 senkklekqk gelmigfkkq lklidvlkrq kmhieaakml sfteeefmka lewgns
//
LOCUS       XP_047288432             176 aa            linear   PRI 05-AUG-2025
DEFINITION  testis-expressed protein 9 isoform X5 [Homo sapiens].
ACCESSION   XP_047288432
VERSION     XP_047288432.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432476.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..176
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..176
                     /product="testis-expressed protein 9 isoform X5"
                     /calculated_mol_wt=19981
     Region          <32..>158
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     CDS             1..176
                     /gene="TEX9"
                     /coded_by="XM_047432476.1:26..556"
                     /db_xref="GeneID:374618"
                     /db_xref="HGNC:HGNC:29585"
                     /db_xref="MIM:620935"
ORIGIN      
        1 magrslcltr ssvpgtpfpp pvqqpstpgp dllaleeeyk rlnaelqakt advvqqakei
       61 ielenkrrlq kqaassqsat evrlnralee aekyklelsk lrqnnkdian eehkkievlk
      121 senkklekqk gelmigfkkq lklidvlkrq kmhieaakml sfteeefmka lewgns
//
LOCUS       XP_011519833            1384 aa            linear   PRI 05-AUG-2025
DEFINITION  kinesin-like protein KIF7 isoform X1 [Homo sapiens].
ACCESSION   XP_011519833
VERSION     XP_011519833.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521531.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1384
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1384
                     /product="kinesin-like protein KIF7 isoform X1"
                     /calculated_mol_wt=154603
     Region          56..391
                     /region_name="KISc_KIF4"
                     /note="Kinesin motor domain, KIF4-like subfamily; cd01372"
                     /db_xref="CDD:276823"
     Site            order(64,135,138,140..143,293)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276823"
     Site            order(343,346,349)
                     /site_type="other"
                     /note="microtubule interaction site [polypeptide binding]"
                     /db_xref="CDD:276823"
     Region          <743..>1239
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     CDS             1..1384
                     /gene="KIF7"
                     /gene_synonym="ACLS; AGBK; HLS2; JBTS12; MMEDF; UNQ340"
                     /coded_by="XM_011521531.3:28..4182"
                     /db_xref="GeneID:374654"
                     /db_xref="HGNC:HGNC:30497"
                     /db_xref="MIM:611254"
ORIGIN      
        1 mpagqaqflh palglstgag griwnrtaqe ansgpeqssl gmgleaqrlp gaeeapvrva
       61 lrvrpllpke llhghqsclq vepglgrvtl grdrhfgfhv vlaedagqea vyqacvqpll
      121 eaffegfnat vfaygqtgsg ktytmgeasv aslledeqgi vpramaeafk lidendlldc
      181 lvhvsylevy keefrdllev gtasrdiqlr edergnvvlc gvkevdvegl devlsllemg
      241 naarhtgath lnhlssrsht vftvtleqrg rapsrlprpa pgqllvskfh fvdlagserv
      301 lktgstgerl kesiqinssl lalgnvisal gdpqrrgshi pyrdskitri lkdslggnak
      361 tvmiacvsps ssdfdetlnt lnyasraqni rnratvnwrp eaerppeeta sgargpprhr
      421 setriihrgr rapgpatasa aaamrlgaec aryractdaa ysllrelqae pglpgaaark
      481 vrdwlcaveg ersalssasg pdsgiesasv edqaaqgagg rkedegaqql ltlqnqvarl
      541 eeenrdflaa ledameqykl qsdrlreqqe emvelrlrle lvrpgwggpr llnglppgsf
      601 vprphtaplg gahahvlgmv ppaclpgdev gseqrgeqvt ngreagaell tevnrlgsgs
      661 saaseeeeee eepprrtlhl rrnrisncsq ragarpgslp erkgpelcle eldaaipgsr
      721 avggskarvq arqvppatas ewrlaqaqqk irelainirm keeligelvr tgkaaqalnr
      781 qhsqrirele qeaeqvrael segqrqlrel egkelqdage rsrlqefrrr vaaaqsqvqv
      841 lkekkqater lvslsaqsek rlqelernvq lmrqqqgqlq rrlreeteqk rrleaemskr
      901 qhrvkelelk heqqqkilki kteeiaafqr krrsgsngsv vsleqqqkie eqkkwldqem
      961 ekvlqqrral eelgeelhkr eailakkeal mqektglesk rlrssqalne divrvssrle
     1021 hlekelseks gqlrqgsaqs qqqirgeids lrqekdsllk qrleidgklr qgsllspeee
     1081 rtlfqldeai ealdaaieyk neaitcrqrv lrasasllsq cemnlmakls ylsssetral
     1141 lckyfdkvvt lreeqhqqqi afselemqle eqqrlvywle valerqrlem drqltlqqke
     1201 heqnmqlllq qsrdhlgegl adsrrqyear iqalekelgr ymwinqelkq klggvnavgh
     1261 srggekrslc segrqapgne delhlapell wlspltegap rtreetrdlv haplpltwkr
     1321 sslcgeeqgs peelrqreaa eplvgrvlpv geaglpwnfg plskprrelr raspgmidvr
     1381 knpl
//
LOCUS       XP_047288433            1382 aa            linear   PRI 05-AUG-2025
DEFINITION  kinesin-like protein KIF7 isoform X2 [Homo sapiens].
ACCESSION   XP_047288433
VERSION     XP_047288433.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432477.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1382
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1382
                     /product="kinesin-like protein KIF7 isoform X2"
                     /calculated_mol_wt=154404
     Region          56..391
                     /region_name="KISc_KIF4"
                     /note="Kinesin motor domain, KIF4-like subfamily; cd01372"
                     /db_xref="CDD:276823"
     Site            order(64,135,138,140..143,293)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276823"
     Site            order(343,346,349)
                     /site_type="other"
                     /note="microtubule interaction site [polypeptide binding]"
                     /db_xref="CDD:276823"
     Region          <741..>1237
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     CDS             1..1382
                     /gene="KIF7"
                     /gene_synonym="ACLS; AGBK; HLS2; JBTS12; MMEDF; UNQ340"
                     /coded_by="XM_047432477.1:28..4176"
                     /db_xref="GeneID:374654"
                     /db_xref="HGNC:HGNC:30497"
                     /db_xref="MIM:611254"
ORIGIN      
        1 mpagqaqflh palglstgag griwnrtaqe ansgpeqssl gmgleaqrlp gaeeapvrva
       61 lrvrpllpke llhghqsclq vepglgrvtl grdrhfgfhv vlaedagqea vyqacvqpll
      121 eaffegfnat vfaygqtgsg ktytmgeasv aslledeqgi vpramaeafk lidendlldc
      181 lvhvsylevy keefrdllev gtasrdiqlr edergnvvlc gvkevdvegl devlsllemg
      241 naarhtgath lnhlssrsht vftvtleqrg rapsrlprpa pgqllvskfh fvdlagserv
      301 lktgstgerl kesiqinssl lalgnvisal gdpqrrgshi pyrdskitri lkdslggnak
      361 tvmiacvsps ssdfdetlnt lnyasraqni rnratvnwrp eaerppeeta sgargpprhr
      421 setriihrgr rapgpatasa aaamrlgaec aryractdaa ysllrelqae pglpgaaark
      481 vrdwlcaveg ersalssasg pdsgiesasv edqaaqgagg rkedegaqql ltlqnqvarl
      541 eeenrdflaa ledameqykl qsdrlreqqe emvelrlrle lvrpgwggpr llnglppgsf
      601 vprphtaplg gahahvlgmv ppaclpgdev gseqrgevtn greagaellt evnrlgsgss
      661 aaseeeeeee epprrtlhlr rnrisncsqr agarpgslpe rkgpelclee ldaaipgsrv
      721 ggskarvqar qvppatasew rlaqaqqkir elainirmke eligelvrtg kaaqalnrqh
      781 sqrireleqe aeqvraelse gqrqlreleg kelqdagers rlqefrrrva aaqsqvqvlk
      841 ekkqaterlv slsaqsekrl qelernvqlm rqqqgqlqrr lreeteqkrr leaemskrqh
      901 rvkelelkhe qqqkilkikt eeiaafqrkr rsgsngsvvs leqqqkieeq kkwldqemek
      961 vlqqrralee lgeelhkrea ilakkealmq ektgleskrl rssqalnedi vrvssrlehl
     1021 ekelseksgq lrqgsaqsqq qirgeidslr qekdsllkqr leidgklrqg sllspeeert
     1081 lfqldeaiea ldaaieykne aitcrqrvlr asasllsqce mnlmaklsyl sssetrallc
     1141 kyfdkvvtlr eeqhqqqiaf selemqleeq qrlvywleva lerqrlemdr qltlqqkehe
     1201 qnmqlllqqs rdhlgeglad srrqyeariq alekelgrym winqelkqkl ggvnavghsr
     1261 ggekrslcse grqapgnede lhlapellwl spltegaprt reetrdlvha plpltwkrss
     1321 lcgeeqgspe elrqreaaep lvgrvlpvge aglpwnfgpl skprrelrra spgmidvrkn
     1381 pl
//
LOCUS       XP_047288434            1342 aa            linear   PRI 05-AUG-2025
DEFINITION  kinesin-like protein KIF7 isoform X3 [Homo sapiens].
ACCESSION   XP_047288434
VERSION     XP_047288434.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432478.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1342
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1342
                     /product="kinesin-like protein KIF7 isoform X3"
                     /calculated_mol_wt=150385
     Region          15..350
                     /region_name="KISc_KIF4"
                     /note="Kinesin motor domain, KIF4-like subfamily; cd01372"
                     /db_xref="CDD:276823"
     Site            order(23,94,97,99..102,252)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276823"
     Site            order(302,305,308)
                     /site_type="other"
                     /note="microtubule interaction site [polypeptide binding]"
                     /db_xref="CDD:276823"
     Region          <701..>1197
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     CDS             1..1342
                     /gene="KIF7"
                     /gene_synonym="ACLS; AGBK; HLS2; JBTS12; MMEDF; UNQ340"
                     /coded_by="XM_047432478.1:94..4122"
                     /db_xref="GeneID:374654"
                     /db_xref="HGNC:HGNC:30497"
                     /db_xref="MIM:611254"
ORIGIN      
        1 mgleaqrlpg aeeapvrval rvrpllpkel lhghqsclqv epglgrvtlg rdrhfgfhvv
       61 laedagqeav yqacvqplle affegfnatv faygqtgsgk tytmgeasva slledeqgiv
      121 pramaeafkl idendlldcl vhvsylevyk eefrdllevg tasrdiqlre dergnvvlcg
      181 vkevdvegld evlsllemgn aarhtgathl nhlssrshtv ftvtleqrgr apsrlprpap
      241 gqllvskfhf vdlagservl ktgstgerlk esiqinssll algnvisalg dpqrrgship
      301 yrdskitril kdslggnakt vmiacvspss sdfdetlntl nyasraqnir nratvnwrpe
      361 aerppeetas gargpprhrs etriihrgrr apgpatasaa aamrlgaeca ryractdaay
      421 sllrelqaep glpgaaarkv rdwlcavege rsalssasgp dsgiesasve dqaaqgaggr
      481 kedegaqqll tlqnqvarle eenrdflaal edameqyklq sdrlreqqee mvelrlrlel
      541 vrpgwggprl lnglppgsfv prphtaplgg ahahvlgmvp paclpgdevg seqrgeqvtn
      601 greagaellt evnrlgsgss aaseeeeeee epprrtlhlr rnrisncsqr agarpgslpe
      661 rkgpelclee ldaaipgsrv ggskarvqar qvppatasew rlaqaqqkir elainirmke
      721 eligelvrtg kaaqalnrqh sqrireleqe aeqvraelse gqrqlreleg kelqdagers
      781 rlqefrrrva aaqsqvqvlk ekkqaterlv slsaqsekrl qelernvqlm rqqqgqlqrr
      841 lreeteqkrr leaemskrqh rvkelelkhe qqqkilkikt eeiaafqrkr rsgsngsvvs
      901 leqqqkieeq kkwldqemek vlqqrralee lgeelhkrea ilakkealmq ektgleskrl
      961 rssqalnedi vrvssrlehl ekelseksgq lrqgsaqsqq qirgeidslr qekdsllkqr
     1021 leidgklrqg sllspeeert lfqldeaiea ldaaieykne aitcrqrvlr asasllsqce
     1081 mnlmaklsyl sssetrallc kyfdkvvtlr eeqhqqqiaf selemqleeq qrlvywleva
     1141 lerqrlemdr qltlqqkehe qnmqlllqqs rdhlgeglad srrqyeariq alekelgrym
     1201 winqelkqkl ggvnavghsr ggekrslcse grqapgnede lhlapellwl spltegaprt
     1261 reetrdlvha plpltwkrss lcgeeqgspe elrqreaaep lvgrvlpvge aglpwnfgpl
     1321 skprrelrra spgmidvrkn pl
//
LOCUS       XP_047288435            1342 aa            linear   PRI 05-AUG-2025
DEFINITION  kinesin-like protein KIF7 isoform X4 [Homo sapiens].
ACCESSION   XP_047288435
VERSION     XP_047288435.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432479.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1342
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1342
                     /product="kinesin-like protein KIF7 isoform X4"
                     /calculated_mol_wt=150328
     Region          15..350
                     /region_name="KISc_KIF4"
                     /note="Kinesin motor domain, KIF4-like subfamily; cd01372"
                     /db_xref="CDD:276823"
     Site            order(23,94,97,99..102,252)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276823"
     Site            order(302,305,308)
                     /site_type="other"
                     /note="microtubule interaction site [polypeptide binding]"
                     /db_xref="CDD:276823"
     Region          <701..>1197
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     CDS             1..1342
                     /gene="KIF7"
                     /gene_synonym="ACLS; AGBK; HLS2; JBTS12; MMEDF; UNQ340"
                     /coded_by="XM_047432479.1:94..4122"
                     /db_xref="GeneID:374654"
                     /db_xref="HGNC:HGNC:30497"
                     /db_xref="MIM:611254"
ORIGIN      
        1 mgleaqrlpg aeeapvrval rvrpllpkel lhghqsclqv epglgrvtlg rdrhfgfhvv
       61 laedagqeav yqacvqplle affegfnatv faygqtgsgk tytmgeasva slledeqgiv
      121 pramaeafkl idendlldcl vhvsylevyk eefrdllevg tasrdiqlre dergnvvlcg
      181 vkevdvegld evlsllemgn aarhtgathl nhlssrshtv ftvtleqrgr apsrlprpap
      241 gqllvskfhf vdlagservl ktgstgerlk esiqinssll algnvisalg dpqrrgship
      301 yrdskitril kdslggnakt vmiacvspss sdfdetlntl nyasraqnir nratvnwrpe
      361 aerppeetas gargpprhrs etriihrgrr apgpatasaa aamrlgaeca ryractdaay
      421 sllrelqaep glpgaaarkv rdwlcavege rsalssasgp dsgiesasve dqaaqgaggr
      481 kedegaqqll tlqnqvarle eenrdflaal edameqyklq sdrlreqqee mvelrlrlel
      541 vrpgwggprl lnglppgsfv prphtaplgg ahahvlgmvp paclpgdevg seqrgevtng
      601 reagaellte vnrlgsgssa aseeeeeeee pprrtlhlrr nrisncsqra garpgslper
      661 kgpelcleel daaipgsrav ggskarvqar qvppatasew rlaqaqqkir elainirmke
      721 eligelvrtg kaaqalnrqh sqrireleqe aeqvraelse gqrqlreleg kelqdagers
      781 rlqefrrrva aaqsqvqvlk ekkqaterlv slsaqsekrl qelernvqlm rqqqgqlqrr
      841 lreeteqkrr leaemskrqh rvkelelkhe qqqkilkikt eeiaafqrkr rsgsngsvvs
      901 leqqqkieeq kkwldqemek vlqqrralee lgeelhkrea ilakkealmq ektgleskrl
      961 rssqalnedi vrvssrlehl ekelseksgq lrqgsaqsqq qirgeidslr qekdsllkqr
     1021 leidgklrqg sllspeeert lfqldeaiea ldaaieykne aitcrqrvlr asasllsqce
     1081 mnlmaklsyl sssetrallc kyfdkvvtlr eeqhqqqiaf selemqleeq qrlvywleva
     1141 lerqrlemdr qltlqqkehe qnmqlllqqs rdhlgeglad srrqyeariq alekelgrym
     1201 winqelkqkl ggvnavghsr ggekrslcse grqapgnede lhlapellwl spltegaprt
     1261 reetrdlvha plpltwkrss lcgeeqgspe elrqreaaep lvgrvlpvge aglpwnfgpl
     1321 skprrelrra spgmidvrkn pl
//
LOCUS       XP_047288436            1341 aa            linear   PRI 05-AUG-2025
DEFINITION  kinesin-like protein KIF7 isoform X5 [Homo sapiens].
ACCESSION   XP_047288436
VERSION     XP_047288436.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432480.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1341
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1341
                     /product="kinesin-like protein KIF7 isoform X5"
                     /calculated_mol_wt=150257
     Region          15..350
                     /region_name="KISc_KIF4"
                     /note="Kinesin motor domain, KIF4-like subfamily; cd01372"
                     /db_xref="CDD:276823"
     Site            order(23,94,97,99..102,252)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276823"
     Site            order(302,305,308)
                     /site_type="other"
                     /note="microtubule interaction site [polypeptide binding]"
                     /db_xref="CDD:276823"
     Region          <700..>1196
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     CDS             1..1341
                     /gene="KIF7"
                     /gene_synonym="ACLS; AGBK; HLS2; JBTS12; MMEDF; UNQ340"
                     /coded_by="XM_047432480.1:94..4119"
                     /db_xref="GeneID:374654"
                     /db_xref="HGNC:HGNC:30497"
                     /db_xref="MIM:611254"
ORIGIN      
        1 mgleaqrlpg aeeapvrval rvrpllpkel lhghqsclqv epglgrvtlg rdrhfgfhvv
       61 laedagqeav yqacvqplle affegfnatv faygqtgsgk tytmgeasva slledeqgiv
      121 pramaeafkl idendlldcl vhvsylevyk eefrdllevg tasrdiqlre dergnvvlcg
      181 vkevdvegld evlsllemgn aarhtgathl nhlssrshtv ftvtleqrgr apsrlprpap
      241 gqllvskfhf vdlagservl ktgstgerlk esiqinssll algnvisalg dpqrrgship
      301 yrdskitril kdslggnakt vmiacvspss sdfdetlntl nyasraqnir nratvnwrpe
      361 aerppeetas gargpprhrs etriihrgrr apgpatasaa aamrlgaeca ryractdaay
      421 sllrelqaep glpgaaarkv rdwlcavege rsalssasgp dsgiesasve dqaaqgaggr
      481 kedegaqqll tlqnqvarle eenrdflaal edameqyklq sdrlreqqee mvelrlrlel
      541 vrpgwggprl lnglppgsfv prphtaplgg ahahvlgmvp paclpgdevg seqrgevtng
      601 reagaellte vnrlgsgssa aseeeeeeee pprrtlhlrr nrisncsqra garpgslper
      661 kgpelcleel daaipgsrvg gskarvqarq vppatasewr laqaqqkire lainirmkee
      721 ligelvrtgk aaqalnrqhs qrireleqea eqvraelseg qrqlrelegk elqdagersr
      781 lqefrrrvaa aqsqvqvlke kkqaterlvs lsaqsekrlq elernvqlmr qqqgqlqrrl
      841 reeteqkrrl eaemskrqhr vkelelkheq qqkilkikte eiaafqrkrr sgsngsvvsl
      901 eqqqkieeqk kwldqemekv lqqrraleel geelhkreai lakkealmqe ktgleskrlr
      961 ssqalnediv rvssrlehle kelseksgql rqgsaqsqqq irgeidslrq ekdsllkqrl
     1021 eidgklrqgs llspeeertl fqldeaieal daaieyknea itcrqrvlra sasllsqcem
     1081 nlmaklsyls ssetrallck yfdkvvtlre eqhqqqiafs elemqleeqq rlvywleval
     1141 erqrlemdrq ltlqqkeheq nmqlllqqsr dhlgeglads rrqyeariqa lekelgrymw
     1201 inqelkqklg gvnavghsrg gekrslcseg rqapgnedel hlapellwls pltegaprtr
     1261 eetrdlvhap lpltwkrssl cgeeqgspee lrqreaaepl vgrvlpvgea glpwnfgpls
     1321 kprrelrras pgmidvrknp l
//
LOCUS       XP_047288437            1312 aa            linear   PRI 05-AUG-2025
DEFINITION  kinesin-like protein KIF7 isoform X6 [Homo sapiens].
ACCESSION   XP_047288437
VERSION     XP_047288437.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432481.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1312
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1312
                     /product="kinesin-like protein KIF7 isoform X6"
                     /calculated_mol_wt=146735
     Region          15..350
                     /region_name="KISc_KIF4"
                     /note="Kinesin motor domain, KIF4-like subfamily; cd01372"
                     /db_xref="CDD:276823"
     Site            order(23,94,97,99..102,252)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276823"
     Site            order(302,305,308)
                     /site_type="other"
                     /note="microtubule interaction site [polypeptide binding]"
                     /db_xref="CDD:276823"
     Region          <701..>1197
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     CDS             1..1312
                     /gene="KIF7"
                     /gene_synonym="ACLS; AGBK; HLS2; JBTS12; MMEDF; UNQ340"
                     /coded_by="XM_047432481.1:94..4032"
                     /db_xref="GeneID:374654"
                     /db_xref="HGNC:HGNC:30497"
                     /db_xref="MIM:611254"
ORIGIN      
        1 mgleaqrlpg aeeapvrval rvrpllpkel lhghqsclqv epglgrvtlg rdrhfgfhvv
       61 laedagqeav yqacvqplle affegfnatv faygqtgsgk tytmgeasva slledeqgiv
      121 pramaeafkl idendlldcl vhvsylevyk eefrdllevg tasrdiqlre dergnvvlcg
      181 vkevdvegld evlsllemgn aarhtgathl nhlssrshtv ftvtleqrgr apsrlprpap
      241 gqllvskfhf vdlagservl ktgstgerlk esiqinssll algnvisalg dpqrrgship
      301 yrdskitril kdslggnakt vmiacvspss sdfdetlntl nyasraqnir nratvnwrpe
      361 aerppeetas gargpprhrs etriihrgrr apgpatasaa aamrlgaeca ryractdaay
      421 sllrelqaep glpgaaarkv rdwlcavege rsalssasgp dsgiesasve dqaaqgaggr
      481 kedegaqqll tlqnqvarle eenrdflaal edameqyklq sdrlreqqee mvelrlrlel
      541 vrpgwggprl lnglppgsfv prphtaplgg ahahvlgmvp paclpgdevg seqrgevtng
      601 reagaellte vnrlgsgssa aseeeeeeee pprrtlhlrr nrisncsqra garpgslper
      661 kgpelcleel daaipgsrav ggskarvqar qvppatasew rlaqaqqkir elainirmke
      721 eligelvrtg kaaqalnrqh sqrireleqe aeqvraelse gqrqlreleg kelqdagers
      781 rlqefrrrva aaqsqvqvlk ekkqaterlv slsaqsekrl qelernvqlm rqqqgqlqrr
      841 lreeteqkrr leaemskrqh rvkelelkhe qqqkilkikt eeiaafqrkr rsgsngsvvs
      901 leqqqkieeq kkwldqemek vlqqrralee lgeelhkrea ilakkealmq ektgleskrl
      961 rssqalnedi vrvssrlehl ekelseksgq lrqgsaqsqq qirgeidslr qekdsllkqr
     1021 leidgklrqg sllspeeert lfqldeaiea ldaaieykne aitcrqrvlr asasllsqce
     1081 mnlmaklsyl sssetrallc kyfdkvvtlr eeqhqqqiaf selemqleeq qrlvywleva
     1141 lerqrlemdr qltlqqkehe qnmqlllqqs rdhlgeglad srrqyeariq alekelgrym
     1201 winqelkqkl ggvnavghsr ggekrslcse grqapgnede lhlapellwl spltegaprt
     1261 reetrdlvha plpltwkrss lcgdssttpi sgpgsedlee phaqgllhtt cn
//
LOCUS       XP_047288438             702 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 710 isoform X1 [Homo sapiens].
ACCESSION   XP_047288438
VERSION     XP_047288438.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432482.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..702
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..702
                     /product="zinc finger protein 710 isoform X1"
                     /calculated_mol_wt=77903
     Region          320..340
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(325,327,329,331..332,335..336,339,353,355,359..360,
                     363..364,367,381,383,385,387..388,391..392,395)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          348..368
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          <358..616
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          376..396
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          404..424
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          432..452
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          460..480
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          488..508
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          516..536
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(521,523,525,527..528,531..532,535,549,551,555..556,
                     559..560,563,577,579,581,583..584,587..588,591)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          544..564
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          572..592
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          600..619
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..702
                     /gene="ZNF710"
                     /coded_by="XM_047432482.1:98..2206"
                     /db_xref="GeneID:374655"
                     /db_xref="HGNC:HGNC:25352"
ORIGIN      
        1 mirssaastf agtgdallas rhgmegfmds gtqtdavvvl slaqaavlgl vsenelfgat
       61 isaeafypdl gpelsgaamg epeppgpdvy qlacngrale epaeeevlev eaacekhtrr
      121 ktrppvrlvp kvkfekveee eqevyevsvp gddkdagpae apaeaasggc dalvqssavk
      181 midlsafsrk prtlrhlprt prpelnvapy dphfpapard gfpepsmalp gpealptecg
      241 fepphlapls dpeapsmesp epvkpeqgfv wqeasefead tagstverhk kaqldrldin
      301 vqiddsylve agdrqkrwqc rmceksytsk ynlvthilgh ngikphscph csklfkqpsh
      361 lqthllthqg trphkcqvch kaftqtshlk rhmllhsevk pyschfcgrg faypselkah
      421 evkhesgrch vcvecgldfs tltqlkrhla shqgptlyqc lecdksfhyr sqlqnhmlkh
      481 qnvrpfvcte cgmefsqihh lkqhslthkg vkefkcevcg reftlqanmk rhmlihtsvr
      541 pyqchicfkt fvqkqtlkth mivhspvkpf kckvcgksfn rmynllghmh lhagskpfkc
      601 pycsskfnlk gnlsrhmkvk hgvmdiglds qggwakrngq srndtnmths gascpvrgvg
      661 rlakaetslg waqvwkggtl eghddnndgi fmssskdlne it
//
LOCUS       XP_047288439             687 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 710 isoform X2 [Homo sapiens].
ACCESSION   XP_047288439
VERSION     XP_047288439.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432483.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..687
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..687
                     /product="zinc finger protein 710 isoform X2"
                     /calculated_mol_wt=76590
     Region          320..340
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(325,327,329,331..332,335..336,339,353,355,359..360,
                     363..364,367,381,383,385,387..388,391..392,395)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          348..368
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          <358..616
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          376..396
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          404..424
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          432..452
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          460..480
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          488..508
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          516..536
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(521,523,525,527..528,531..532,535,549,551,555..556,
                     559..560,563,577,579,581,583..584,587..588,591)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          544..564
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          572..592
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          600..619
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..687
                     /gene="ZNF710"
                     /coded_by="XM_047432483.1:98..2161"
                     /db_xref="GeneID:374655"
                     /db_xref="HGNC:HGNC:25352"
ORIGIN      
        1 mirssaastf agtgdallas rhgmegfmds gtqtdavvvl slaqaavlgl vsenelfgat
       61 isaeafypdl gpelsgaamg epeppgpdvy qlacngrale epaeeevlev eaacekhtrr
      121 ktrppvrlvp kvkfekveee eqevyevsvp gddkdagpae apaeaasggc dalvqssavk
      181 midlsafsrk prtlrhlprt prpelnvapy dphfpapard gfpepsmalp gpealptecg
      241 fepphlapls dpeapsmesp epvkpeqgfv wqeasefead tagstverhk kaqldrldin
      301 vqiddsylve agdrqkrwqc rmceksytsk ynlvthilgh ngikphscph csklfkqpsh
      361 lqthllthqg trphkcqvch kaftqtshlk rhmllhsevk pyschfcgrg faypselkah
      421 evkhesgrch vcvecgldfs tltqlkrhla shqgptlyqc lecdksfhyr sqlqnhmlkh
      481 qnvrpfvcte cgmefsqihh lkqhslthkg vkefkcevcg reftlqanmk rhmlihtsvr
      541 pyqchicfkt fvqkqtlkth mivhspvkpf kckvcgksfn rmynllghmh lhagskpfkc
      601 pycsskfnlk gnlsrhmkvk hgvmdiglds qdpmmeltgt dpseldgqqe medfeenays
      661 yasvdssaea svlteqamke mayynvl
//
LOCUS       XP_005254964             679 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 710 isoform X3 [Homo sapiens].
ACCESSION   XP_005254964
VERSION     XP_005254964.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254907.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..679
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..679
                     /product="zinc finger protein 710 isoform X3"
                     /calculated_mol_wt=75644
     Region          297..317
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(302,304,306,308..309,312..313,316,330,332,336..337,
                     340..341,344,358,360,362,364..365,368..369,372)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          325..345
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          <335..593
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          353..373
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          381..401
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          409..429
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          437..457
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          465..485
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          493..513
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(498,500,502,504..505,508..509,512,526,528,532..533,
                     536..537,540,554,556,558,560..561,564..565,568)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          521..541
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          549..569
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          577..596
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..679
                     /gene="ZNF710"
                     /coded_by="XM_005254907.5:320..2359"
                     /db_xref="GeneID:374655"
                     /db_xref="HGNC:HGNC:25352"
ORIGIN      
        1 megfmdsgtq tdavvvlsla qaavlglvse nelfgatisa eafypdlgpe lsgaamgepe
       61 ppgpdvyqla cngraleepa eeevleveaa cekhtrrktr ppvrlvpkvk fekveeeeqe
      121 vyevsvpgdd kdagpaeapa eaasggcdal vqssavkmid lsafsrkprt lrhlprtprp
      181 elnvapydph fpapardgfp epsmalpgpe alptecgfep phlaplsdpe apsmespepv
      241 kpeqgfvwqe asefeadtag stverhkkaq ldrldinvqi ddsylveagd rqkrwqcrmc
      301 eksytskynl vthilghngi kphscphcsk lfkqpshlqt hllthqgtrp hkcqvchkaf
      361 tqtshlkrhm llhsevkpys chfcgrgfay pselkahevk hesgrchvcv ecgldfstlt
      421 qlkrhlashq gptlyqclec dksfhyrsql qnhmlkhqnv rpfvctecgm efsqihhlkq
      481 hslthkgvke fkcevcgref tlqanmkrhm lihtsvrpyq chicfktfvq kqtlkthmiv
      541 hspvkpfkck vcgksfnrmy nllghmhlha gskpfkcpyc sskfnlkgnl srhmkvkhgv
      601 mdigldsqgg wakrngqsrn dtnmthsgas cpvrgvgrla kaetslgwaq vwkggtlegh
      661 ddnndgifms sskdlneit
//
LOCUS       XP_047288440             679 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 710 isoform X3 [Homo sapiens].
ACCESSION   XP_047288440
VERSION     XP_047288440.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432484.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..679
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..679
                     /product="zinc finger protein 710 isoform X3"
                     /calculated_mol_wt=75644
     Region          297..317
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(302,304,306,308..309,312..313,316,330,332,336..337,
                     340..341,344,358,360,362,364..365,368..369,372)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          325..345
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          <335..593
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          353..373
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          381..401
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          409..429
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          437..457
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          465..485
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          493..513
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(498,500,502,504..505,508..509,512,526,528,532..533,
                     536..537,540,554,556,558,560..561,564..565,568)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          521..541
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          549..569
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          577..596
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..679
                     /gene="ZNF710"
                     /coded_by="XM_047432484.1:77..2116"
                     /db_xref="GeneID:374655"
                     /db_xref="HGNC:HGNC:25352"
ORIGIN      
        1 megfmdsgtq tdavvvlsla qaavlglvse nelfgatisa eafypdlgpe lsgaamgepe
       61 ppgpdvyqla cngraleepa eeevleveaa cekhtrrktr ppvrlvpkvk fekveeeeqe
      121 vyevsvpgdd kdagpaeapa eaasggcdal vqssavkmid lsafsrkprt lrhlprtprp
      181 elnvapydph fpapardgfp epsmalpgpe alptecgfep phlaplsdpe apsmespepv
      241 kpeqgfvwqe asefeadtag stverhkkaq ldrldinvqi ddsylveagd rqkrwqcrmc
      301 eksytskynl vthilghngi kphscphcsk lfkqpshlqt hllthqgtrp hkcqvchkaf
      361 tqtshlkrhm llhsevkpys chfcgrgfay pselkahevk hesgrchvcv ecgldfstlt
      421 qlkrhlashq gptlyqclec dksfhyrsql qnhmlkhqnv rpfvctecgm efsqihhlkq
      481 hslthkgvke fkcevcgref tlqanmkrhm lihtsvrpyq chicfktfvq kqtlkthmiv
      541 hspvkpfkck vcgksfnrmy nllghmhlha gskpfkcpyc sskfnlkgnl srhmkvkhgv
      601 mdigldsqgg wakrngqsrn dtnmthsgas cpvrgvgrla kaetslgwaq vwkggtlegh
      661 ddnndgifms sskdlneit
//
LOCUS       XP_005254963             679 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 710 isoform X3 [Homo sapiens].
ACCESSION   XP_005254963
VERSION     XP_005254963.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254906.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..679
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..679
                     /product="zinc finger protein 710 isoform X3"
                     /calculated_mol_wt=75644
     Region          297..317
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(302,304,306,308..309,312..313,316,330,332,336..337,
                     340..341,344,358,360,362,364..365,368..369,372)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          325..345
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          <335..593
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          353..373
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          381..401
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          409..429
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          437..457
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          465..485
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          493..513
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(498,500,502,504..505,508..509,512,526,528,532..533,
                     536..537,540,554,556,558,560..561,564..565,568)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          521..541
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          549..569
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          577..596
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..679
                     /gene="ZNF710"
                     /coded_by="XM_005254906.5:177..2216"
                     /db_xref="GeneID:374655"
                     /db_xref="HGNC:HGNC:25352"
ORIGIN      
        1 megfmdsgtq tdavvvlsla qaavlglvse nelfgatisa eafypdlgpe lsgaamgepe
       61 ppgpdvyqla cngraleepa eeevleveaa cekhtrrktr ppvrlvpkvk fekveeeeqe
      121 vyevsvpgdd kdagpaeapa eaasggcdal vqssavkmid lsafsrkprt lrhlprtprp
      181 elnvapydph fpapardgfp epsmalpgpe alptecgfep phlaplsdpe apsmespepv
      241 kpeqgfvwqe asefeadtag stverhkkaq ldrldinvqi ddsylveagd rqkrwqcrmc
      301 eksytskynl vthilghngi kphscphcsk lfkqpshlqt hllthqgtrp hkcqvchkaf
      361 tqtshlkrhm llhsevkpys chfcgrgfay pselkahevk hesgrchvcv ecgldfstlt
      421 qlkrhlashq gptlyqclec dksfhyrsql qnhmlkhqnv rpfvctecgm efsqihhlkq
      481 hslthkgvke fkcevcgref tlqanmkrhm lihtsvrpyq chicfktfvq kqtlkthmiv
      541 hspvkpfkck vcgksfnrmy nllghmhlha gskpfkcpyc sskfnlkgnl srhmkvkhgv
      601 mdigldsqgg wakrngqsrn dtnmthsgas cpvrgvgrla kaetslgwaq vwkggtlegh
      661 ddnndgifms sskdlneit
//
LOCUS       XP_011519844             679 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 710 isoform X3 [Homo sapiens].
ACCESSION   XP_011519844
VERSION     XP_011519844.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521542.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..679
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..679
                     /product="zinc finger protein 710 isoform X3"
                     /calculated_mol_wt=75644
     Region          297..317
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(302,304,306,308..309,312..313,316,330,332,336..337,
                     340..341,344,358,360,362,364..365,368..369,372)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          325..345
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          <335..593
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          353..373
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          381..401
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          409..429
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          437..457
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          465..485
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          493..513
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(498,500,502,504..505,508..509,512,526,528,532..533,
                     536..537,540,554,556,558,560..561,564..565,568)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          521..541
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          549..569
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          577..596
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..679
                     /gene="ZNF710"
                     /coded_by="XM_011521542.4:142..2181"
                     /db_xref="GeneID:374655"
                     /db_xref="HGNC:HGNC:25352"
ORIGIN      
        1 megfmdsgtq tdavvvlsla qaavlglvse nelfgatisa eafypdlgpe lsgaamgepe
       61 ppgpdvyqla cngraleepa eeevleveaa cekhtrrktr ppvrlvpkvk fekveeeeqe
      121 vyevsvpgdd kdagpaeapa eaasggcdal vqssavkmid lsafsrkprt lrhlprtprp
      181 elnvapydph fpapardgfp epsmalpgpe alptecgfep phlaplsdpe apsmespepv
      241 kpeqgfvwqe asefeadtag stverhkkaq ldrldinvqi ddsylveagd rqkrwqcrmc
      301 eksytskynl vthilghngi kphscphcsk lfkqpshlqt hllthqgtrp hkcqvchkaf
      361 tqtshlkrhm llhsevkpys chfcgrgfay pselkahevk hesgrchvcv ecgldfstlt
      421 qlkrhlashq gptlyqclec dksfhyrsql qnhmlkhqnv rpfvctecgm efsqihhlkq
      481 hslthkgvke fkcevcgref tlqanmkrhm lihtsvrpyq chicfktfvq kqtlkthmiv
      541 hspvkpfkck vcgksfnrmy nllghmhlha gskpfkcpyc sskfnlkgnl srhmkvkhgv
      601 mdigldsqgg wakrngqsrn dtnmthsgas cpvrgvgrla kaetslgwaq vwkggtlegh
      661 ddnndgifms sskdlneit
//
LOCUS       XP_047288441             679 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 710 isoform X3 [Homo sapiens].
ACCESSION   XP_047288441
VERSION     XP_047288441.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432485.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..679
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..679
                     /product="zinc finger protein 710 isoform X3"
                     /calculated_mol_wt=75644
     Region          297..317
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(302,304,306,308..309,312..313,316,330,332,336..337,
                     340..341,344,358,360,362,364..365,368..369,372)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          325..345
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          <335..593
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          353..373
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          381..401
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          409..429
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          437..457
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          465..485
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          493..513
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(498,500,502,504..505,508..509,512,526,528,532..533,
                     536..537,540,554,556,558,560..561,564..565,568)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          521..541
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          549..569
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          577..596
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..679
                     /gene="ZNF710"
                     /coded_by="XM_047432485.1:448..2487"
                     /db_xref="GeneID:374655"
                     /db_xref="HGNC:HGNC:25352"
ORIGIN      
        1 megfmdsgtq tdavvvlsla qaavlglvse nelfgatisa eafypdlgpe lsgaamgepe
       61 ppgpdvyqla cngraleepa eeevleveaa cekhtrrktr ppvrlvpkvk fekveeeeqe
      121 vyevsvpgdd kdagpaeapa eaasggcdal vqssavkmid lsafsrkprt lrhlprtprp
      181 elnvapydph fpapardgfp epsmalpgpe alptecgfep phlaplsdpe apsmespepv
      241 kpeqgfvwqe asefeadtag stverhkkaq ldrldinvqi ddsylveagd rqkrwqcrmc
      301 eksytskynl vthilghngi kphscphcsk lfkqpshlqt hllthqgtrp hkcqvchkaf
      361 tqtshlkrhm llhsevkpys chfcgrgfay pselkahevk hesgrchvcv ecgldfstlt
      421 qlkrhlashq gptlyqclec dksfhyrsql qnhmlkhqnv rpfvctecgm efsqihhlkq
      481 hslthkgvke fkcevcgref tlqanmkrhm lihtsvrpyq chicfktfvq kqtlkthmiv
      541 hspvkpfkck vcgksfnrmy nllghmhlha gskpfkcpyc sskfnlkgnl srhmkvkhgv
      601 mdigldsqgg wakrngqsrn dtnmthsgas cpvrgvgrla kaetslgwaq vwkggtlegh
      661 ddnndgifms sskdlneit
//
LOCUS       XP_047288442             678 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 710 isoform X4 [Homo sapiens].
ACCESSION   XP_047288442
VERSION     XP_047288442.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432486.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..678
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..678
                     /product="zinc finger protein 710 isoform X4"
                     /calculated_mol_wt=75845
     Region          311..331
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(316,318,320,322..323,326..327,330,344,346,350..351,
                     354..355,358,372,374,376,378..379,382..383,386)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          339..359
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          <349..607
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          367..387
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          395..415
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          423..443
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          451..471
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          479..499
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          507..527
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(512,514,516,518..519,522..523,526,540,542,546..547,
                     550..551,554,568,570,572,574..575,578..579,582)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          535..555
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          563..583
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          591..610
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..678
                     /gene="ZNF710"
                     /coded_by="XM_047432486.1:241..2277"
                     /db_xref="GeneID:374655"
                     /db_xref="HGNC:HGNC:25352"
ORIGIN      
        1 mflvcdalla srhgmegfmd sgtqtdavvv lslaqaavlg lvsenelfga tisaeafypd
       61 lgpelsgaam gepeppgpdv yqlacngral eepaeeevle veaacekhtr rktrppvrlv
      121 pkvkfekvee eeqevyevsv pgddkdagpa eapaeaasgg cdalvqssav kmidlsafsr
      181 kprtlrhlpr tprpelnvap ydphfpapar dgfpepsmal pgpealptec gfepphlapl
      241 sdpeapsmes pepvkpeqgf vwqeasefea dtagstverh kkaqldrldi nvqiddsylv
      301 eagdrqkrwq crmceksyts kynlvthilg hngikphscp hcsklfkqps hlqthllthq
      361 gtrphkcqvc hkaftqtshl krhmllhsev kpyschfcgr gfaypselka hevkhesgrc
      421 hvcvecgldf stltqlkrhl ashqgptlyq clecdksfhy rsqlqnhmlk hqnvrpfvct
      481 ecgmefsqih hlkqhslthk gvkefkcevc greftlqanm krhmlihtsv rpyqchicfk
      541 tfvqkqtlkt hmivhspvkp fkckvcgksf nrmynllghm hlhagskpfk cpycsskfnl
      601 kgnlsrhmkv khgvmdigld sqdpmmeltg tdpseldgqq emedfeenay syasvdssae
      661 asvlteqamk emayynvl
//
LOCUS       XP_047288443             664 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 710 isoform X5 [Homo sapiens].
ACCESSION   XP_047288443
VERSION     XP_047288443.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432487.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..664
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..664
                     /product="zinc finger protein 710 isoform X5"
                     /calculated_mol_wt=74330
     Region          297..317
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(302,304,306,308..309,312..313,316,330,332,336..337,
                     340..341,344,358,360,362,364..365,368..369,372)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          325..345
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          <335..593
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          353..373
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          381..401
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          409..429
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          437..457
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          465..485
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          493..513
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(498,500,502,504..505,508..509,512,526,528,532..533,
                     536..537,540,554,556,558,560..561,564..565,568)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          521..541
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          549..569
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          577..596
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..664
                     /gene="ZNF710"
                     /coded_by="XM_047432487.1:294..2288"
                     /db_xref="GeneID:374655"
                     /db_xref="HGNC:HGNC:25352"
ORIGIN      
        1 megfmdsgtq tdavvvlsla qaavlglvse nelfgatisa eafypdlgpe lsgaamgepe
       61 ppgpdvyqla cngraleepa eeevleveaa cekhtrrktr ppvrlvpkvk fekveeeeqe
      121 vyevsvpgdd kdagpaeapa eaasggcdal vqssavkmid lsafsrkprt lrhlprtprp
      181 elnvapydph fpapardgfp epsmalpgpe alptecgfep phlaplsdpe apsmespepv
      241 kpeqgfvwqe asefeadtag stverhkkaq ldrldinvqi ddsylveagd rqkrwqcrmc
      301 eksytskynl vthilghngi kphscphcsk lfkqpshlqt hllthqgtrp hkcqvchkaf
      361 tqtshlkrhm llhsevkpys chfcgrgfay pselkahevk hesgrchvcv ecgldfstlt
      421 qlkrhlashq gptlyqclec dksfhyrsql qnhmlkhqnv rpfvctecgm efsqihhlkq
      481 hslthkgvke fkcevcgref tlqanmkrhm lihtsvrpyq chicfktfvq kqtlkthmiv
      541 hspvkpfkck vcgksfnrmy nllghmhlha gskpfkcpyc sskfnlkgnl srhmkvkhgv
      601 mdigldsqdp mmeltgtdps eldgqqemed feenaysyas vdssaeasvl teqamkemay
      661 ynvl
//
LOCUS       XP_047288444             664 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 710 isoform X5 [Homo sapiens].
ACCESSION   XP_047288444
VERSION     XP_047288444.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432488.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..664
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..664
                     /product="zinc finger protein 710 isoform X5"
                     /calculated_mol_wt=74330
     Region          297..317
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(302,304,306,308..309,312..313,316,330,332,336..337,
                     340..341,344,358,360,362,364..365,368..369,372)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          325..345
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          <335..593
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          353..373
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          381..401
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          409..429
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          437..457
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          465..485
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          493..513
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(498,500,502,504..505,508..509,512,526,528,532..533,
                     536..537,540,554,556,558,560..561,564..565,568)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          521..541
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          549..569
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          577..596
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..664
                     /gene="ZNF710"
                     /coded_by="XM_047432488.1:177..2171"
                     /db_xref="GeneID:374655"
                     /db_xref="HGNC:HGNC:25352"
ORIGIN      
        1 megfmdsgtq tdavvvlsla qaavlglvse nelfgatisa eafypdlgpe lsgaamgepe
       61 ppgpdvyqla cngraleepa eeevleveaa cekhtrrktr ppvrlvpkvk fekveeeeqe
      121 vyevsvpgdd kdagpaeapa eaasggcdal vqssavkmid lsafsrkprt lrhlprtprp
      181 elnvapydph fpapardgfp epsmalpgpe alptecgfep phlaplsdpe apsmespepv
      241 kpeqgfvwqe asefeadtag stverhkkaq ldrldinvqi ddsylveagd rqkrwqcrmc
      301 eksytskynl vthilghngi kphscphcsk lfkqpshlqt hllthqgtrp hkcqvchkaf
      361 tqtshlkrhm llhsevkpys chfcgrgfay pselkahevk hesgrchvcv ecgldfstlt
      421 qlkrhlashq gptlyqclec dksfhyrsql qnhmlkhqnv rpfvctecgm efsqihhlkq
      481 hslthkgvke fkcevcgref tlqanmkrhm lihtsvrpyq chicfktfvq kqtlkthmiv
      541 hspvkpfkck vcgksfnrmy nllghmhlha gskpfkcpyc sskfnlkgnl srhmkvkhgv
      601 mdigldsqdp mmeltgtdps eldgqqemed feenaysyas vdssaeasvl teqamkemay
      661 ynvl
//
LOCUS       XP_011519845             640 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 710 isoform X6 [Homo sapiens].
ACCESSION   XP_011519845
VERSION     XP_011519845.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521543.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XP_011519845.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..640
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..640
                     /product="zinc finger protein 710 isoform X6"
                     /calculated_mol_wt=71405
     Region          320..340
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(325,327,329,331..332,335..336,339,353,355,359..360,
                     363..364,367,381,383,385,387..388,391..392,395)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          348..368
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          <358..616
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          376..396
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          404..424
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          432..452
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          460..480
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          488..508
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          516..536
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(521,523,525,527..528,531..532,535,549,551,555..556,
                     559..560,563,577,579,581,583..584,587..588,591)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          544..564
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          572..592
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          600..619
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..640
                     /gene="ZNF710"
                     /coded_by="XM_011521543.4:98..2020"
                     /db_xref="GeneID:374655"
                     /db_xref="HGNC:HGNC:25352"
ORIGIN      
        1 mirssaastf agtgdallas rhgmegfmds gtqtdavvvl slaqaavlgl vsenelfgat
       61 isaeafypdl gpelsgaamg epeppgpdvy qlacngrale epaeeevlev eaacekhtrr
      121 ktrppvrlvp kvkfekveee eqevyevsvp gddkdagpae apaeaasggc dalvqssavk
      181 midlsafsrk prtlrhlprt prpelnvapy dphfpapard gfpepsmalp gpealptecg
      241 fepphlapls dpeapsmesp epvkpeqgfv wqeasefead tagstverhk kaqldrldin
      301 vqiddsylve agdrqkrwqc rmceksytsk ynlvthilgh ngikphscph csklfkqpsh
      361 lqthllthqg trphkcqvch kaftqtshlk rhmllhsevk pyschfcgrg faypselkah
      421 evkhesgrch vcvecgldfs tltqlkrhla shqgptlyqc lecdksfhyr sqlqnhmlkh
      481 qnvrpfvcte cgmefsqihh lkqhslthkg vkefkcevcg reftlqanmk rhmlihtsvr
      541 pyqchicfkt fvqkqtlkth mivhspvkpf kckvcgksfn rmynllghmh lhagskpfkc
      601 pycsskfnlk gnlsrhmkvk hgvmdiglds qdaeteeqrt
//
LOCUS       XP_047288445             152 aa            linear   PRI 05-AUG-2025
DEFINITION  inhibitory synaptic factor 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047288445
VERSION     XP_047288445.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432489.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..152
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..152
                     /product="inhibitory synaptic factor 1 isoform X1"
                     /calculated_mol_wt=16370
     Region          <1..139
                     /region_name="DUF4589"
                     /note="Domain of unknown function (DUF4589); pfam15252"
                     /db_xref="CDD:464592"
     CDS             1..152
                     /gene="INSYN1"
                     /gene_synonym="C15orf59"
                     /coded_by="XM_047432489.1:177..635"
                     /db_xref="GeneID:388135"
                     /db_xref="HGNC:HGNC:33753"
                     /db_xref="MIM:617128"
ORIGIN      
        1 mnggtpipng prvetpdsss eeafgagptv ksqlpqrtpg trervrfsdk vlyhalccdd
       61 eegdgeqeve eeevglppep ahteahagph kpspapyksr rspltsrhsg stlapeqtrr
      121 vtrnsstqtv sdkstqtvlp ytatrqkarg kn
//
LOCUS       XP_011519849             455 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin-associated protein 1-like isoform X1 [Homo sapiens].
ACCESSION   XP_011519849
VERSION     XP_011519849.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521547.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..455
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..455
                     /product="ubiquitin-associated protein 1-like isoform X1"
                     /calculated_mol_wt=47969
     CDS             1..455
                     /gene="UBAP1L"
                     /gene_synonym="UBAP-1L"
                     /coded_by="XM_011521547.4:174..1541"
                     /db_xref="GeneID:390595"
                     /db_xref="HGNC:HGNC:40028"
ORIGIN      
        1 mnaldgvpfk lpkgfvigte plpgpelsvp acgevllgsm hdfslertal fwveaagqgp
       61 spyqcgdpgt asappawlll vspehglapa pttirdpeag hqerpeeege deaeassgse
      121 eepapsslqp gspaspgpgr rlcsldvlrg vrlelagarr rlsegklvsr prallhglrg
      181 hralslcpsp aqsprsaspp gpapqhpaap aspprpstag aipplrshkp tvaslspytc
      241 lpplggapqp lnphkshpdt aadllsalsq eeqdligpvv algyplrrai ialqktgrqs
      301 lsqflsylsa cdrllrqgye eglvdeamem fqfsesqvsr ascqgprgwk gwgctqepgv
      361 qghtspqsqs vgpacgsvgr lpdssalrrr wprelqqgqr qgsscasgss svtwassrtg
      421 srrccwsmat aeskpwrsww pvpsdhggtp rclgi
//
LOCUS       XP_016877661             314 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin-associated protein 1-like isoform X2 [Homo sapiens].
ACCESSION   XP_016877661
VERSION     XP_016877661.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022172.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..314
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..314
                     /product="ubiquitin-associated protein 1-like isoform X2"
                     /calculated_mol_wt=32586
     CDS             1..314
                     /gene="UBAP1L"
                     /gene_synonym="UBAP-1L"
                     /coded_by="XM_017022172.3:174..1118"
                     /db_xref="GeneID:390595"
                     /db_xref="HGNC:HGNC:40028"
ORIGIN      
        1 mnaldgvpfk lpkgfvigte plpgpelsvp acgevllgsm hdfslertal fwveaagqgp
       61 spyqcgdpgt asappawlll vspehglapa pttirdpeag hqerpeeege deaeassgse
      121 eepapsslqp gspaspgpgr rlcsldvlrg vrlelagarr rlsegklvsr prallhglrg
      181 hralslcpsp aqsprsaspp gpapqhpaap aspprpstag aipplrshkp tvaslspytc
      241 lpplggapqp lnphkshpdt aadllsalsq eeqdligpvv algyplrrai ialqktgrqs
      301 lsqsslywky ggds
//
LOCUS       XP_005254432             447 aa            linear   PRI 05-AUG-2025
DEFINITION  SHC-transforming protein 4 isoform X1 [Homo sapiens].
ACCESSION   XP_005254432
VERSION     XP_005254432.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254375.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..447
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..447
                     /product="SHC-transforming protein 4 isoform X1"
                     /calculated_mol_wt=49149
     Region          13..164
                     /region_name="PTB_Shc"
                     /note="Shc-like phosphotyrosine-binding (PTB) domain;
                     cd01209"
                     /db_xref="CDD:269920"
     Site            order(23..26,31,106..114,126,132,145,148..149,151..152,
                     155..156,159..162,164)
                     /site_type="other"
                     /note="phosphopeptide binding site [polypeptide binding]"
                     /db_xref="CDD:269920"
     Site            order(69,73,96)
                     /site_type="other"
                     /note="phosphoinositide binding site [chemical binding]"
                     /db_xref="CDD:269920"
     Region          335..435
                     /region_name="SH2_SHC"
                     /note="Src homology 2 (SH2) domain found in SH2 adaptor
                     protein C (SHC); cd09925"
                     /db_xref="CDD:198179"
     Site            order(350,366,368,373,378,387..389)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198179"
     Site            order(377,388,390,392,397..399,404,410,421..423)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198179"
     CDS             1..447
                     /gene="SHC4"
                     /gene_synonym="RaLP; SHCD"
                     /coded_by="XM_005254375.4:137..1480"
                     /db_xref="GeneID:399694"
                     /db_xref="HGNC:HGNC:16743"
                     /db_xref="MIM:617372"
ORIGIN      
        1 mcdkspnfss enymgcvevl qsmrsldfgm rtqvtreais rlceavpgan gaikkrkppv
       61 kflstvlgks nlqfsgmnik ltistcsltl mnldnqqiia nhhmqsisfa sggdpdttdy
      121 vayvakdpvn qrachilech ngmaqdvist igqafelrfk qylknpslnt sceseevhid
      181 shaeeredhe yyneipgkqp pvggvsdmri kvqateqmay cpiqceklcy lpgnskcssv
      241 yencleqsra ignvhprgvq sqrdtsllkh tcrvdlfddp cyintqalqs tpgsagnqrs
      301 aqplgspwhc gkapetvqpg ataqpasshs lphikqqlws eecyhgklsr kaaesllvkd
      361 gdflvresat spgqyvlsgl qggqakhlll vdpegkvrtk dhvfdnvghl iryhmdnslp
      421 iissgsevsl kqpvrkdnnp allhsnk
//
LOCUS       XP_047288448             344 aa            linear   PRI 05-AUG-2025
DEFINITION  SHC-transforming protein 4 isoform X2 [Homo sapiens].
ACCESSION   XP_047288448
VERSION     XP_047288448.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432492.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..344
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..344
                     /product="SHC-transforming protein 4 isoform X2"
                     /calculated_mol_wt=37773
     Region          <1..61
                     /region_name="PH-like"
                     /note="Pleckstrin homology-like domain; cl17171"
                     /db_xref="CDD:473070"
     Region          232..332
                     /region_name="SH2_SHC"
                     /note="Src homology 2 (SH2) domain found in SH2 adaptor
                     protein C (SHC); cd09925"
                     /db_xref="CDD:198179"
     Site            order(247,263,265,270,275,284..286)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198179"
     Site            order(274,285,287,289,294..296,301,307,318..320)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198179"
     CDS             1..344
                     /gene="SHC4"
                     /gene_synonym="RaLP; SHCD"
                     /coded_by="XM_047432492.1:494..1528"
                     /db_xref="GeneID:399694"
                     /db_xref="HGNC:HGNC:16743"
                     /db_xref="MIM:617372"
ORIGIN      
        1 mqsisfasgg dpdttdyvay vakdpvnqra chilechngm aqdvistigq afelrfkqyl
       61 knpslntsce seevhidsha eeredheyyn eipgkqppvg gvsdmrikvq ateqmaycpi
      121 qceklcylpg nskcssvyen cleqsraign vhprgvqsqr dtsllkhtcr vdlfddpcyi
      181 ntqalqstpg sagnqrsaqp lgspwhcgka petvqpgata qpasshslph ikqqlwseec
      241 yhgklsrkaa esllvkdgdf lvresatspg qyvlsglqgg qakhlllvdp egkvrtkdhv
      301 fdnvghliry hmdnslpiis sgsevslkqp vrkdnnpall hsnk
//
LOCUS       XP_047288449             344 aa            linear   PRI 05-AUG-2025
DEFINITION  SHC-transforming protein 4 isoform X2 [Homo sapiens].
ACCESSION   XP_047288449
VERSION     XP_047288449.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432493.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..344
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..344
                     /product="SHC-transforming protein 4 isoform X2"
                     /calculated_mol_wt=37773
     Region          <1..61
                     /region_name="PH-like"
                     /note="Pleckstrin homology-like domain; cl17171"
                     /db_xref="CDD:473070"
     Region          232..332
                     /region_name="SH2_SHC"
                     /note="Src homology 2 (SH2) domain found in SH2 adaptor
                     protein C (SHC); cd09925"
                     /db_xref="CDD:198179"
     Site            order(247,263,265,270,275,284..286)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198179"
     Site            order(274,285,287,289,294..296,301,307,318..320)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198179"
     CDS             1..344
                     /gene="SHC4"
                     /gene_synonym="RaLP; SHCD"
                     /coded_by="XM_047432493.1:209..1243"
                     /db_xref="GeneID:399694"
                     /db_xref="HGNC:HGNC:16743"
                     /db_xref="MIM:617372"
ORIGIN      
        1 mqsisfasgg dpdttdyvay vakdpvnqra chilechngm aqdvistigq afelrfkqyl
       61 knpslntsce seevhidsha eeredheyyn eipgkqppvg gvsdmrikvq ateqmaycpi
      121 qceklcylpg nskcssvyen cleqsraign vhprgvqsqr dtsllkhtcr vdlfddpcyi
      181 ntqalqstpg sagnqrsaqp lgspwhcgka petvqpgata qpasshslph ikqqlwseec
      241 yhgklsrkaa esllvkdgdf lvresatspg qyvlsglqgg qakhlllvdp egkvrtkdhv
      301 fdnvghliry hmdnslpiis sgsevslkqp vrkdnnpall hsnk
//
LOCUS       XP_016877667              81 aa            linear   PRI 05-AUG-2025
DEFINITION  cortexin-2 isoform X1 [Homo sapiens].
ACCESSION   XP_016877667
VERSION     XP_016877667.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022178.2
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 3% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..81
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..81
                     /product="cortexin-2 isoform X1"
                     /calculated_mol_wt=8849
     Region          9..81
                     /region_name="Cortexin"
                     /note="Cortexin of kidney; pfam11057"
                     /db_xref="CDD:314086"
     CDS             1..81
                     /gene="CTXN2"
                     /coded_by="XM_017022178.2:381..626"
                     /db_xref="GeneID:399697"
                     /db_xref="HGNC:HGNC:31109"
ORIGIN      
        1 msstycgnss akmsvnevsa fsltleqktg fafvgilcif lglliircfk illdpyssmp
       61 sstwedevee fdkgtfeyal a
//
LOCUS       XP_047288450              81 aa            linear   PRI 05-AUG-2025
DEFINITION  cortexin-2 isoform X1 [Homo sapiens].
ACCESSION   XP_047288450
VERSION     XP_047288450.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432494.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 3% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..81
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..81
                     /product="cortexin-2 isoform X1"
                     /calculated_mol_wt=8849
     Region          9..81
                     /region_name="Cortexin"
                     /note="Cortexin of kidney; pfam11057"
                     /db_xref="CDD:314086"
     CDS             1..81
                     /gene="CTXN2"
                     /coded_by="XM_047432494.1:664..909"
                     /db_xref="GeneID:399697"
                     /db_xref="HGNC:HGNC:31109"
ORIGIN      
        1 msstycgnss akmsvnevsa fsltleqktg fafvgilcif lglliircfk illdpyssmp
       61 sstwedevee fdkgtfeyal a
//
LOCUS       XP_006720567              81 aa            linear   PRI 05-AUG-2025
DEFINITION  cortexin-2 isoform X1 [Homo sapiens].
ACCESSION   XP_006720567
VERSION     XP_006720567.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720504.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..81
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..81
                     /product="cortexin-2 isoform X1"
                     /calculated_mol_wt=8849
     Region          9..81
                     /region_name="Cortexin"
                     /note="Cortexin of kidney; pfam11057"
                     /db_xref="CDD:314086"
     CDS             1..81
                     /gene="CTXN2"
                     /coded_by="XM_006720504.3:124..369"
                     /db_xref="GeneID:399697"
                     /db_xref="HGNC:HGNC:31109"
ORIGIN      
        1 msstycgnss akmsvnevsa fsltleqktg fafvgilcif lglliircfk illdpyssmp
       61 sstwedevee fdkgtfeyal a
//
LOCUS       XP_011519857             445 aa            linear   PRI 05-AUG-2025
DEFINITION  lysyl oxidase homolog 1 isoform X1 [Homo sapiens].
ACCESSION   XP_011519857
VERSION     XP_011519857.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521555.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..445
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..445
                     /product="lysyl oxidase homolog 1 isoform X1"
                     /calculated_mol_wt=47610
     Region          240..>435
                     /region_name="dnaA"
                     /note="chromosomal replication initiator protein DnaA;
                     cl42516"
                     /db_xref="CDD:455861"
     CDS             1..445
                     /gene="LOXL1"
                     /gene_synonym="LOL; LOXL"
                     /coded_by="XM_011521555.3:323..1660"
                     /db_xref="GeneID:4016"
                     /db_xref="HGNC:HGNC:6665"
                     /db_xref="MIM:153456"
ORIGIN      
        1 malargsrql galvwgaclc vlvhgqqaqp gqgsdparwr qliqwenngq vysllnsgse
       61 yvpagpqrse sssrvllaga pqaqqrrshg sprrrqapsl plpgrvgsdt vrgqarhpfg
      121 fgqvpdnwre vavgdstgma rartsvsqqr hggsassvsa safastyrqq psypqqfpyp
      181 qapfvsqyen ydpasrtydq gfvyyrpagg gvgagaaava sagviypyqp raryeeyggg
      241 eelpeyppqg fypaperpyv pppppppdgl drryshslys egtpgfeqay pdpgpeaaqa
      301 hggdprlgwy ppyanpppea ygppralepp ylpvrssdtp ppggerngaq qgrlsvgsvy
      361 rpnqngrvtp aqtpacpgrk vegqeqdgqa pgsgtswgtr dhkdggslqt spgrltpgla
      421 geraraslrs lfmlfslpwt pfpal
//
LOCUS       XP_047288454             431 aa            linear   PRI 05-AUG-2025
DEFINITION  lysyl oxidase homolog 1 isoform X2 [Homo sapiens].
ACCESSION   XP_047288454
VERSION     XP_047288454.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432498.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..431
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..431
                     /product="lysyl oxidase homolog 1 isoform X2"
                     /calculated_mol_wt=45945
     Region          240..>417
                     /region_name="dnaA"
                     /note="chromosomal replication initiator protein DnaA;
                     cl42516"
                     /db_xref="CDD:455861"
     CDS             1..431
                     /gene="LOXL1"
                     /gene_synonym="LOL; LOXL"
                     /coded_by="XM_047432498.1:323..1618"
                     /db_xref="GeneID:4016"
                     /db_xref="HGNC:HGNC:6665"
                     /db_xref="MIM:153456"
ORIGIN      
        1 malargsrql galvwgaclc vlvhgqqaqp gqgsdparwr qliqwenngq vysllnsgse
       61 yvpagpqrse sssrvllaga pqaqqrrshg sprrrqapsl plpgrvgsdt vrgqarhpfg
      121 fgqvpdnwre vavgdstgma rartsvsqqr hggsassvsa safastyrqq psypqqfpyp
      181 qapfvsqyen ydpasrtydq gfvyyrpagg gvgagaaava sagviypyqp raryeeyggg
      241 eelpeyppqg fypaperpyv pppppppdgl drryshslys egtpgfeqay pdpgpeaaqa
      301 hggdprlgwy ppyanpppea ygppralepp ylpvrssdtp ppggerngaq qgrlsvgsvy
      361 rpnqngrvtp aqtpacpgrk vegqeqdgqa pgsgtswgtr dhkdggslqt spgrltpgla
      421 geraraslrs p
//
LOCUS       XP_016877668             225 aa            linear   PRI 05-AUG-2025
DEFINITION  lysyl oxidase homolog 1 isoform X3 [Homo sapiens].
ACCESSION   XP_016877668
VERSION     XP_016877668.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022179.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..225
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..225
                     /product="lysyl oxidase homolog 1 isoform X3"
                     /calculated_mol_wt=25447
     Region          21..220
                     /region_name="Lysyl_oxidase"
                     /note="Lysyl oxidase; pfam01186"
                     /db_xref="CDD:460102"
     CDS             1..225
                     /gene="LOXL1"
                     /gene_synonym="LOL; LOXL"
                     /coded_by="XM_017022179.2:387..1064"
                     /db_xref="GeneID:4016"
                     /db_xref="HGNC:HGNC:6665"
                     /db_xref="MIM:153456"
ORIGIN      
        1 msklfqevla aptpqssrcl pdlvpdpnyv qastyvqrah lyslrcaaee kclastayap
       61 eatdydvrvl lrfpqrvknq gtadflpnrp rhtwewhsch qhyhsmdefs hydlldaatg
      121 kkvaeghkas fcledstcdf gnlkryacts htqglspgcy dtynadidcq widitdvqpg
      181 nyilkvhvnp kyivlesdft nnvvrcnihy tgryvsatnc kivqs
//
LOCUS       XP_016877669             337 aa            linear   PRI 05-AUG-2025
DEFINITION  dual oxidase maturation factor 2 isoform X1 [Homo sapiens].
ACCESSION   XP_016877669
VERSION     XP_016877669.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022180.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..337
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..337
                     /product="dual oxidase maturation factor 2 isoform X1"
                     /calculated_mol_wt=36327
     Region          10..302
                     /region_name="DuoxA"
                     /note="Dual oxidase maturation factor; pfam10204"
                     /db_xref="CDD:462995"
     CDS             1..337
                     /gene="DUOXA2"
                     /gene_synonym="SIMNIPHOM; TDH5"
                     /coded_by="XM_017022180.2:281..1294"
                     /db_xref="GeneID:405753"
                     /db_xref="HGNC:HGNC:32698"
                     /db_xref="MIM:612772"
ORIGIN      
        1 mtlwngvlpf ypqprhaagf svpllivilv flalaasfll ilpgirghsr wfwlvrvlls
       61 lfigaeivav hfsaewfvgt vntntsykaf saarvtarvr llvglegini tltvarspta
      121 gspmspphpt gtpvhqlnet idyneqftwr lkenyaaeya nalekglpdp vlylaekftp
      181 sspcglyhqy hlaghyasat lwvafcfwll snvllstpap lygglalltt gafalfgvfa
      241 lasissvplc plrlgssalt tqygaafwvt latgvlclfl ggavvslqyv rpsalrtlld
      301 qsakdcsqer ggsplilgdp lhkqaalpdl kcittnl
//
LOCUS       XP_011519859             824 aa            linear   PRI 05-AUG-2025
DEFINITION  leukocyte tyrosine kinase receptor isoform X1 [Homo sapiens].
ACCESSION   XP_011519859
VERSION     XP_011519859.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521557.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..824
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..824
                     /product="leukocyte tyrosine kinase receptor isoform X1"
                     /calculated_mol_wt=88324
     Region          463..739
                     /region_name="PTKc_ALK_LTK"
                     /note="Catalytic domain of the Protein Tyrosine Kinases,
                     Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase;
                     cd05036"
                     /db_xref="CDD:270632"
     Site            order(476,478..479,484,502,504,550..554,556..557,603,
                     607..608,610,623..624,642..646,655,689)
                     /site_type="active"
                     /db_xref="CDD:270632"
     Site            order(476,478..479,484,502,504,550..554,556..557,607..608,
                     610,623..624)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270632"
     Site            order(603,607,642..646,655,689)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270632"
     Site            623..648
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270632"
     CDS             1..824
                     /gene="LTK"
                     /gene_synonym="TYK1"
                     /coded_by="XM_011521557.3:119..2593"
                     /db_xref="GeneID:4058"
                     /db_xref="HGNC:HGNC:6721"
                     /db_xref="MIM:151520"
ORIGIN      
        1 mgcwgqllvw fgaagailcs spgsqetflr ssplplasps prdpkvsapp silepaspln
       61 spgtegswlf stcgasgrhg ptqtqcdgay agtsvvvtvg aagqlrgvql wrvpgpgqyl
      121 isaygaaggk gaknhlsrah gvfvsaifsl glgeslyilv gqqgedacpg gspesqlvcl
      181 gesraveeha amdgsegvpg srrwaggggg gggatyvfrv ragelepllv aaggggrayl
      241 rprdrgrtqa speklenrse apgsggrgga aggdasetdn lwadgedgvs fihpsselfl
      301 qplavllltv tenhgeveir rhlncshcpl rdcqwqaelq laeclcpegm elavdnvtcm
      361 dlhkppgplv lmvavvatst lsllmvcgvl ilgtkrlagt vdsrlllsmk qkkwqglqem
      421 rlpspelels klrtsairta pnpyycqvgl gpaqswplpp gvtevspanv tllralghga
      481 fgevyeglvi glpgdssplq vaiktlpelc spqdeldflm ealiiskfrh qnivrcvgls
      541 lratprlill elmsggdmks flrhsrphlg qpsplvmrdl lqlaqdiaqg chyleenhfi
      601 hrdiaarncl lscagpsrva kigdfgmard iyrasyyrrg drallpvkwm ppeaflegif
      661 tsktdswsfg vllweifslg ympypgrtnq evldfvvggg rmdpprgcpg pvyrimtqcw
      721 qhepelrpsf asilerlqyc tqdpdvlnsl lpmelgptpe eegtsglgnr sleclrppqp
      781 qelspeklks wggsplgpwl ssglkplksr glqpqnlwnp tyrs
//
LOCUS       XP_047288455             819 aa            linear   PRI 05-AUG-2025
DEFINITION  leukocyte tyrosine kinase receptor isoform X2 [Homo sapiens].
ACCESSION   XP_047288455
VERSION     XP_047288455.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432499.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..819
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..819
                     /product="leukocyte tyrosine kinase receptor isoform X2"
                     /calculated_mol_wt=87784
     Region          458..734
                     /region_name="PTKc_ALK_LTK"
                     /note="Catalytic domain of the Protein Tyrosine Kinases,
                     Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase;
                     cd05036"
                     /db_xref="CDD:270632"
     Site            order(471,473..474,479,497,499,545..549,551..552,598,
                     602..603,605,618..619,637..641,650,684)
                     /site_type="active"
                     /db_xref="CDD:270632"
     Site            order(471,473..474,479,497,499,545..549,551..552,602..603,
                     605,618..619)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270632"
     Site            order(598,602,637..641,650,684)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270632"
     Site            618..643
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270632"
     CDS             1..819
                     /gene="LTK"
                     /gene_synonym="TYK1"
                     /coded_by="XM_047432499.1:119..2578"
                     /db_xref="GeneID:4058"
                     /db_xref="HGNC:HGNC:6721"
                     /db_xref="MIM:151520"
ORIGIN      
        1 mgcwgqllvw fgaagailcs spgsqetflr ssplplasps prdpkvsapp silepaspln
       61 spgtegswlf stcgasgrhg ptqtqcdgay agtsvvvtvg aagqlrgvql wrvpgpgqyl
      121 isaygaaggk gaknhlsrah gvfvsaifsl glgeslyilv gqqgedacpg gspesqlvcl
      181 gesraveeha amdgsegvpg srrwaggggg gggatyvfrv ragelepllv aaggggrayl
      241 rprdrgrtqa speklenrse apgsggrgga aggdasetdn lwadgedgvs fihpsselfl
      301 qplavtenhg eveirrhlnc shcplrdcqw qaelqlaecl cpegmelavd nvtcmdlhkp
      361 pgplvlmvav vatstlsllm vcgvlilgtk rlagtvdsrl llsmkqkkwq glqemrlpsp
      421 elelsklrts airtapnpyy cqvglgpaqs wplppgvtev spanvtllra lghgafgevy
      481 eglviglpgd ssplqvaikt lpelcspqde ldflmealii skfrhqnivr cvglslratp
      541 rlillelmsg gdmksflrhs rphlgqpspl vmrdllqlaq diaqgchyle enhfihrdia
      601 arncllscag psrvakigdf gmardiyras yyrrgdrall pvkwmppeaf legiftsktd
      661 swsfgvllwe ifslgympyp grtnqevldf vvgggrmdpp rgcpgpvyri mtqcwqhepe
      721 lrpsfasile rlqyctqdpd vlnsllpmel gptpeeegts glgnrslecl rppqpqelsp
      781 eklkswggsp lgpwlssglk plksrglqpq nlwnptyrs
//
LOCUS       XP_047288456             808 aa            linear   PRI 05-AUG-2025
DEFINITION  leukocyte tyrosine kinase receptor isoform X3 [Homo sapiens].
ACCESSION   XP_047288456
VERSION     XP_047288456.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432500.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..808
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..808
                     /product="leukocyte tyrosine kinase receptor isoform X3"
                     /calculated_mol_wt=86622
     Region          447..723
                     /region_name="PTKc_ALK_LTK"
                     /note="Catalytic domain of the Protein Tyrosine Kinases,
                     Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase;
                     cd05036"
                     /db_xref="CDD:270632"
     Site            order(460,462..463,468,486,488,534..538,540..541,587,
                     591..592,594,607..608,626..630,639,673)
                     /site_type="active"
                     /db_xref="CDD:270632"
     Site            order(460,462..463,468,486,488,534..538,540..541,591..592,
                     594,607..608)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270632"
     Site            order(587,591,626..630,639,673)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270632"
     Site            607..632
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270632"
     CDS             1..808
                     /gene="LTK"
                     /gene_synonym="TYK1"
                     /coded_by="XM_047432500.1:119..2545"
                     /db_xref="GeneID:4058"
                     /db_xref="HGNC:HGNC:6721"
                     /db_xref="MIM:151520"
ORIGIN      
        1 mgcwgqllvw fgaagailcs spgsqetflr ssplplasps prdpkvsapp silepaspln
       61 spgtegswlf stcgasgrhg ptqtqcdgay agtsvvvtvg aagqlrgvql wrvpgpgqyl
      121 isaygaaggk gaknhlsrah gvfvsaifsl glgeslyilv gqqgedacpg gspesqlvcl
      181 gesraveeha amdgsegvpg srrwaggggg gggatyvfrv ragelepllv aaggggrayl
      241 rprdrgrtqa speklenrse apgsggrgga aggdasetdn lwadgedgvs fihpsselfl
      301 qplavllltv tenhgeveir rhlncshcpl rdcqwqaelq laeclcpegm elavdnvtcm
      361 dlhkppgplv lmvavvatst lsllmvcgvl ilvkqkkwqg lqemrlpspe lelsklrtsa
      421 irtapnpyyc qvglgpaqsw plppgvtevs panvtllral ghgafgevye glviglpgds
      481 splqvaiktl pelcspqdel dflmealiis kfrhqnivrc vglslratpr lillelmsgg
      541 dmksflrhsr phlgqpsplv mrdllqlaqd iaqgchylee nhfihrdiaa rncllscagp
      601 srvakigdfg mardiyrasy yrrgdrallp vkwmppeafl egiftsktds wsfgvllwei
      661 fslgympypg rtnqevldfv vgggrmdppr gcpgpvyrim tqcwqhepel rpsfasiler
      721 lqyctqdpdv lnsllpmelg ptpeeegtsg lgnrsleclr ppqpqelspe klkswggspl
      781 gpwlssglkp lksrglqpqn lwnptyrs
//
LOCUS       XP_047288457             776 aa            linear   PRI 05-AUG-2025
DEFINITION  leukocyte tyrosine kinase receptor isoform X4 [Homo sapiens].
ACCESSION   XP_047288457
VERSION     XP_047288457.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432501.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..776
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..776
                     /product="leukocyte tyrosine kinase receptor isoform X4"
                     /calculated_mol_wt=83339
     Region          415..691
                     /region_name="PTKc_ALK_LTK"
                     /note="Catalytic domain of the Protein Tyrosine Kinases,
                     Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase;
                     cd05036"
                     /db_xref="CDD:270632"
     Site            order(428,430..431,436,454,456,502..506,508..509,555,
                     559..560,562,575..576,594..598,607,641)
                     /site_type="active"
                     /db_xref="CDD:270632"
     Site            order(428,430..431,436,454,456,502..506,508..509,559..560,
                     562,575..576)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270632"
     Site            order(555,559,594..598,607,641)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270632"
     Site            575..600
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270632"
     CDS             1..776
                     /gene="LTK"
                     /gene_synonym="TYK1"
                     /coded_by="XM_047432501.1:119..2449"
                     /db_xref="GeneID:4058"
                     /db_xref="HGNC:HGNC:6721"
                     /db_xref="MIM:151520"
ORIGIN      
        1 mgcwgqllvw fgaagailcs spgsqetflr ssplplasps prdpkvsapp silepaspln
       61 spgtegswlf stcgasgrhg ptqtqcdgay agtsvvvtvg aagqlrgvql wrvpgpgqyl
      121 isaygaaggk gaknhlsrah gvfvsaifsl glgeslyilv gqqgedacpg gspesqlvcl
      181 gesraveeha amdgsegvpg srrwaggggg gggatyvfrv ragelepllv aaggggrayl
      241 rprdrgrtqa speklenrse apgsggrgga aggdasetdn lwadgedgvs fihpsselfl
      301 qplavllltv tenhgeveir rhlncshcpl rdcqwqaelq laeclcpegm elavdnvtcm
      361 vkqkkwqglq emrlpspele lsklrtsair tapnpyycqv glgpaqswpl ppgvtevspa
      421 nvtllralgh gafgevyegl viglpgdssp lqvaiktlpe lcspqdeldf lmealiiskf
      481 rhqnivrcvg lslratprli llelmsggdm ksflrhsrph lgqpsplvmr dllqlaqdia
      541 qgchyleenh fihrdiaarn cllscagpsr vakigdfgma rdiyrasyyr rgdrallpvk
      601 wmppeafleg iftsktdsws fgvllweifs lgympypgrt nqevldfvvg ggrmdpprgc
      661 pgpvyrimtq cwqhepelrp sfasilerlq yctqdpdvln sllpmelgpt peeegtsglg
      721 nrsleclrpp qpqelspekl kswggsplgp wlssglkplk srglqpqnlw nptyrs
//
LOCUS       XP_047288458             739 aa            linear   PRI 05-AUG-2025
DEFINITION  leukocyte tyrosine kinase receptor isoform X5 [Homo sapiens].
ACCESSION   XP_047288458
VERSION     XP_047288458.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432502.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..739
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..739
                     /product="leukocyte tyrosine kinase receptor isoform X5"
                     /calculated_mol_wt=79123
     Region          419..654
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..739
                     /gene="LTK"
                     /gene_synonym="TYK1"
                     /coded_by="XM_047432502.1:119..2338"
                     /db_xref="GeneID:4058"
                     /db_xref="HGNC:HGNC:6721"
                     /db_xref="MIM:151520"
ORIGIN      
        1 mgcwgqllvw fgaagailcs spgsqetflr ssplplasps prdpkvsapp silepaspln
       61 spgtegswlf stcgasgrhg ptqtqcdgay agtsvvvtvg aagqlrgvql wrvpgpgqyl
      121 isaygaaggk gaknhlsrah gvfvsaifsl glgeslyilv gqqgedacpg gspesqlvcl
      181 gesraveeha amdgsegvpg srrwaggggg gggatyvfrv ragelepllv aaggggrayl
      241 rprdrgrtqa speklenrse apgsggrgga aggdasetdn lwadgedgvs fihpsselfl
      301 qplavllltv tenhgeveir rhlncshcpl rdcqwqaelq laeclcpegm elavdnvtcm
      361 dlhkppgplv lmvavvatst lsllmvcgvl ilggawpgpv lasatrchrg fpsqcysaqt
      421 lpelcspqde ldflmealii skfrhqnivr cvglslratp rlillelmsg gdmksflrhs
      481 rphlgqpspl vmrdllqlaq diaqgchyle enhfihrdia arncllscag psrvakigdf
      541 gmardiyras yyrrgdrall pvkwmppeaf legiftsktd swsfgvllwe ifslgympyp
      601 grtnqevldf vvgggrmdpp rgcpgpvyri mtqcwqhepe lrpsfasile rlqyctqdpd
      661 vlnsllpmel gptpeeegts glgnrslecl rppqpqelsp eklkswggsp lgpwlssglk
      721 plksrglqpq nlwnptyrs
//
LOCUS       XP_047288459             475 aa            linear   PRI 05-AUG-2025
DEFINITION  leukocyte tyrosine kinase receptor isoform X6 [Homo sapiens].
ACCESSION   XP_047288459
VERSION     XP_047288459.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432503.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..475
                     /product="leukocyte tyrosine kinase receptor isoform X6"
                     /calculated_mol_wt=52447
     Region          114..390
                     /region_name="PTKc_ALK_LTK"
                     /note="Catalytic domain of the Protein Tyrosine Kinases,
                     Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase;
                     cd05036"
                     /db_xref="CDD:270632"
     Site            order(127,129..130,135,153,155,201..205,207..208,254,
                     258..259,261,274..275,293..297,306,340)
                     /site_type="active"
                     /db_xref="CDD:270632"
     Site            order(127,129..130,135,153,155,201..205,207..208,258..259,
                     261,274..275)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270632"
     Site            order(254,258,293..297,306,340)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270632"
     Site            274..299
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270632"
     CDS             1..475
                     /gene="LTK"
                     /gene_synonym="TYK1"
                     /coded_by="XM_047432503.1:223..1650"
                     /db_xref="GeneID:4058"
                     /db_xref="HGNC:HGNC:6721"
                     /db_xref="MIM:151520"
ORIGIN      
        1 melavdnvtc mdlhkppgpl vlmvavvats tlsllmvcgv lilgtkrlag tvdsrlllsm
       61 kqkkwqglqe mrlpspelel sklrtsairt apnpyycqvg lgpaqswplp pgvtevspan
      121 vtllralghg afgevyeglv iglpgdsspl qvaiktlpel cspqdeldfl mealiiskfr
      181 hqnivrcvgl slratprlil lelmsggdmk sflrhsrphl gqpsplvmrd llqlaqdiaq
      241 gchyleenhf ihrdiaarnc llscagpsrv akigdfgmar diyrasyyrr gdrallpvkw
      301 mppeaflegi ftsktdswsf gvllweifsl gympypgrtn qevldfvvgg grmdpprgcp
      361 gpvyrimtqc wqhepelrps fasilerlqy ctqdpdvlns llpmelgptp eeegtsglgn
      421 rsleclrppq pqelspeklk swggsplgpw lssglkplks rglqpqnlwn ptyrs
//
LOCUS       XP_024305687             475 aa            linear   PRI 05-AUG-2025
DEFINITION  leukocyte tyrosine kinase receptor isoform X6 [Homo sapiens].
ACCESSION   XP_024305687
VERSION     XP_024305687.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449919.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XP_024305687.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..475
                     /product="leukocyte tyrosine kinase receptor isoform X6"
                     /calculated_mol_wt=52447
     Region          114..390
                     /region_name="PTKc_ALK_LTK"
                     /note="Catalytic domain of the Protein Tyrosine Kinases,
                     Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase;
                     cd05036"
                     /db_xref="CDD:270632"
     Site            order(127,129..130,135,153,155,201..205,207..208,254,
                     258..259,261,274..275,293..297,306,340)
                     /site_type="active"
                     /db_xref="CDD:270632"
     Site            order(127,129..130,135,153,155,201..205,207..208,258..259,
                     261,274..275)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270632"
     Site            order(254,258,293..297,306,340)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270632"
     Site            274..299
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270632"
     CDS             1..475
                     /gene="LTK"
                     /gene_synonym="TYK1"
                     /coded_by="XM_024449919.2:479..1906"
                     /db_xref="GeneID:4058"
                     /db_xref="HGNC:HGNC:6721"
                     /db_xref="MIM:151520"
ORIGIN      
        1 melavdnvtc mdlhkppgpl vlmvavvats tlsllmvcgv lilgtkrlag tvdsrlllsm
       61 kqkkwqglqe mrlpspelel sklrtsairt apnpyycqvg lgpaqswplp pgvtevspan
      121 vtllralghg afgevyeglv iglpgdsspl qvaiktlpel cspqdeldfl mealiiskfr
      181 hqnivrcvgl slratprlil lelmsggdmk sflrhsrphl gqpsplvmrd llqlaqdiaq
      241 gchyleenhf ihrdiaarnc llscagpsrv akigdfgmar diyrasyyrr gdrallpvkw
      301 mppeaflegi ftsktdswsf gvllweifsl gympypgrtn qevldfvvgg grmdpprgcp
      361 gpvyrimtqc wqhepelrps fasilerlqy ctqdpdvlns llpmelgptp eeegtsglgn
      421 rsleclrppq pqelspeklk swggsplgpw lssglkplks rglqpqnlwn ptyrs
//
LOCUS       XP_047288461             459 aa            linear   PRI 05-AUG-2025
DEFINITION  leukocyte tyrosine kinase receptor isoform X7 [Homo sapiens].
ACCESSION   XP_047288461
VERSION     XP_047288461.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432505.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..459
                     /product="leukocyte tyrosine kinase receptor isoform X7"
                     /calculated_mol_wt=50746
     Region          98..374
                     /region_name="PTKc_ALK_LTK"
                     /note="Catalytic domain of the Protein Tyrosine Kinases,
                     Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase;
                     cd05036"
                     /db_xref="CDD:270632"
     Site            order(111,113..114,119,137,139,185..189,191..192,238,
                     242..243,245,258..259,277..281,290,324)
                     /site_type="active"
                     /db_xref="CDD:270632"
     Site            order(111,113..114,119,137,139,185..189,191..192,242..243,
                     245,258..259)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270632"
     Site            order(238,242,277..281,290,324)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270632"
     Site            258..283
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270632"
     CDS             1..459
                     /gene="LTK"
                     /gene_synonym="TYK1"
                     /coded_by="XM_047432505.1:464..1843"
                     /db_xref="GeneID:4058"
                     /db_xref="HGNC:HGNC:6721"
                     /db_xref="MIM:151520"
ORIGIN      
        1 melavdnvtc mdlhkppgpl vlmvavvats tlsllmvcgv lilvkqkkwq glqemrlpsp
       61 elelsklrts airtapnpyy cqvglgpaqs wplppgvtev spanvtllra lghgafgevy
      121 eglviglpgd ssplqvaikt lpelcspqde ldflmealii skfrhqnivr cvglslratp
      181 rlillelmsg gdmksflrhs rphlgqpspl vmrdllqlaq diaqgchyle enhfihrdia
      241 arncllscag psrvakigdf gmardiyras yyrrgdrall pvkwmppeaf legiftsktd
      301 swsfgvllwe ifslgympyp grtnqevldf vvgggrmdpp rgcpgpvyri mtqcwqhepe
      361 lrpsfasile rlqyctqdpd vlnsllpmel gptpeeegts glgnrslecl rppqpqelsp
      421 eklkswggsp lgpwlssglk plksrglqpq nlwnptyrs
//
LOCUS       XP_047288462             405 aa            linear   PRI 05-AUG-2025
DEFINITION  leukocyte tyrosine kinase receptor isoform X8 [Homo sapiens].
ACCESSION   XP_047288462
VERSION     XP_047288462.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432506.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..405
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..405
                     /product="leukocyte tyrosine kinase receptor isoform X8"
                     /calculated_mol_wt=44902
     Region          44..320
                     /region_name="PTKc_ALK_LTK"
                     /note="Catalytic domain of the Protein Tyrosine Kinases,
                     Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase;
                     cd05036"
                     /db_xref="CDD:270632"
     Site            order(57,59..60,65,83,85,131..135,137..138,184,188..189,
                     191,204..205,223..227,236,270)
                     /site_type="active"
                     /db_xref="CDD:270632"
     Site            order(57,59..60,65,83,85,131..135,137..138,188..189,191,
                     204..205)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270632"
     Site            order(184,188,223..227,236,270)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270632"
     Site            204..229
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270632"
     CDS             1..405
                     /gene="LTK"
                     /gene_synonym="TYK1"
                     /coded_by="XM_047432506.1:52..1269"
                     /db_xref="GeneID:4058"
                     /db_xref="HGNC:HGNC:6721"
                     /db_xref="MIM:151520"
ORIGIN      
        1 mrlpspelel sklrtsairt apnpyycqvg lgpaqswplp pgvtevspan vtllralghg
       61 afgevyeglv iglpgdsspl qvaiktlpel cspqdeldfl mealiiskfr hqnivrcvgl
      121 slratprlil lelmsggdmk sflrhsrphl gqpsplvmrd llqlaqdiaq gchyleenhf
      181 ihrdiaarnc llscagpsrv akigdfgmar diyrasyyrr gdrallpvkw mppeaflegi
      241 ftsktdswsf gvllweifsl gympypgrtn qevldfvvgg grmdpprgcp gpvyrimtqc
      301 wqhepelrps fasilerlqy ctqdpdvlns llpmelgptp eeegtsglgn rsleclrppq
      361 pqelspeklk swggsplgpw lssglkplks rglqpqnlwn ptyrs
//
LOCUS       XP_011519863             235 aa            linear   PRI 05-AUG-2025
DEFINITION  mothers against decapentaplegic homolog 6 isoform X1 [Homo
            sapiens].
ACCESSION   XP_011519863
VERSION     XP_011519863.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521561.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..235
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..235
                     /product="mothers against decapentaplegic homolog 6
                     isoform X1"
                     /calculated_mol_wt=26104
     Region          61..233
                     /region_name="MH2_SMAD_6"
                     /note="C-terminal Mad Homology 2 (MH2) domain in SMAD6;
                     cd10499"
                     /db_xref="CDD:199824"
     Site            order(76,84..85,87,96..100,104,108..111,113..114,120,
                     124..125,127,197,221,228,230,232)
                     /site_type="other"
                     /note="putative trimer interface [polypeptide binding]"
                     /db_xref="CDD:199824"
     CDS             1..235
                     /gene="SMAD6"
                     /gene_synonym="AOVD2; HsT17432; MADH6; MADH7"
                     /coded_by="XM_011521561.3:4614..5321"
                     /db_xref="GeneID:4091"
                     /db_xref="HGNC:HGNC:6772"
                     /db_xref="MIM:602931"
ORIGIN      
        1 msrmgkpiet qksppppysr lsprdeykpl dlsdstlsyt eteatnslit apgefsdasm
       61 spdatkpshw csvaywehrt rvgrlyavyd qavsifydlp qgsgfclgql nleqrsesvr
      121 rtrskigfgi llskepdgvw aynrgehpif vnsptldapg gralvvrkvp pgysikvfdf
      181 ersglqhape pdaadgpydp nsvrisfakg wgpcysrqfi tscpcwleil lnnpr
//
LOCUS       XP_024305689            1175 aa            linear   PRI 05-AUG-2025
DEFINITION  alpha-mannosidase 2x isoform X1 [Homo sapiens].
ACCESSION   XP_024305689
VERSION     XP_024305689.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449921.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1175
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1175
                     /product="alpha-mannosidase 2x isoform X1"
                     /calculated_mol_wt=133261
     Region          136..1174
                     /region_name="PLN02701"
                     /note="alpha-mannosidase"
                     /db_xref="CDD:178304"
     CDS             1..1175
                     /gene="MAN2A2"
                     /gene_synonym="alpha-MIIx; MANA2X"
                     /coded_by="XM_024449921.2:330..3857"
                     /db_xref="GeneID:4122"
                     /db_xref="HGNC:HGNC:6825"
                     /db_xref="MIM:600988"
ORIGIN      
        1 mklkkqvtvc gaaifcvavf slylmldrvq hdptrhqngg nfprsqisvl qnrieqleql
       61 leenheiish ikdsvlelta naegppamlp yytvngswvv ppeprpsffs ispqdcqfal
      121 ggrgqkpelq mltvseelpf dnvdggvwrq gfdisydphd wdaedlqvfv vphshndpgw
      181 iktfdkyyte qtqhilnsmv sklqedprrr flwaevsffa kwwdninvqk raavrrlvgn
      241 gqleiatggw vmpdeanshy falidqlieg hqwlernlga tprsgwavdp fgysstmpyl
      301 lrranltsml iqrvhyaikk hfaathslef mwrqtwdsds stdifchmmp fysydvphtc
      361 gpdpkiccqf dfkrlpggri ncpwkvppra iteanvaera allldqyrkk sqlfrsnvll
      421 vplgddfryd kpqewdaqff nyqrlfdffn srpnlhvqaq fgtlsdyfda lykrtgvepg
      481 arppgfpvls gdffsyadre dhywtgyyts rpfyksldrv leahlrgaev lyslaaahar
      541 rsglagrypl sdftlltear rtlglfqhhd aitgtakeav vvdygvrllr slvnlkqvii
      601 haahylvlgd ketyhfdpea pflqvddtrl shdalpertv iqldssprfv vlfnpleqer
      661 fsmvsllvns prvrvlseeg qplavqisah wssateavpd vyqvsvpvrl palglgvlql
      721 qlgldghrtl pssvriylhg rqlsvsrhea fplrvidsgt sdfalsnrym qvwfsgltgl
      781 lksirrvdee heqqvdmqvl vygtrtskdk sgaylflpdg eakpyvpkep pvlrvtegpf
      841 fsevvayyeh ihqavrlynl pgveglsldi sslvdirdyv nkelalhiht didsqgifft
      901 dlngfqvqpr rylkklplqa nfypmpvmay iqdaqkrltl htaqalgvss lkdgqlevil
      961 drrlmqddnr glgqglkdnk rtcnrfrlll errtvgsepd ffsklaamfr glifhssrsg
     1021 nrevqdshst sypsllshlt smylnapala lpvarmqlpg pglrsfhpla sslpcdfhll
     1081 nlrtlqaeed tlpsaetali lhrkgfdcgl eaknlgfnct tsqgkvalgs lfhgldvvfl
     1141 qptsltllyp laspsnstdv ylepmeiatf rlrlg
//
LOCUS       XP_005254967            1175 aa            linear   PRI 05-AUG-2025
DEFINITION  alpha-mannosidase 2x isoform X1 [Homo sapiens].
ACCESSION   XP_005254967
VERSION     XP_005254967.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254910.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1175
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1175
                     /product="alpha-mannosidase 2x isoform X1"
                     /calculated_mol_wt=133261
     Region          136..1174
                     /region_name="PLN02701"
                     /note="alpha-mannosidase"
                     /db_xref="CDD:178304"
     CDS             1..1175
                     /gene="MAN2A2"
                     /gene_synonym="alpha-MIIx; MANA2X"
                     /coded_by="XM_005254910.4:164..3691"
                     /db_xref="GeneID:4122"
                     /db_xref="HGNC:HGNC:6825"
                     /db_xref="MIM:600988"
ORIGIN      
        1 mklkkqvtvc gaaifcvavf slylmldrvq hdptrhqngg nfprsqisvl qnrieqleql
       61 leenheiish ikdsvlelta naegppamlp yytvngswvv ppeprpsffs ispqdcqfal
      121 ggrgqkpelq mltvseelpf dnvdggvwrq gfdisydphd wdaedlqvfv vphshndpgw
      181 iktfdkyyte qtqhilnsmv sklqedprrr flwaevsffa kwwdninvqk raavrrlvgn
      241 gqleiatggw vmpdeanshy falidqlieg hqwlernlga tprsgwavdp fgysstmpyl
      301 lrranltsml iqrvhyaikk hfaathslef mwrqtwdsds stdifchmmp fysydvphtc
      361 gpdpkiccqf dfkrlpggri ncpwkvppra iteanvaera allldqyrkk sqlfrsnvll
      421 vplgddfryd kpqewdaqff nyqrlfdffn srpnlhvqaq fgtlsdyfda lykrtgvepg
      481 arppgfpvls gdffsyadre dhywtgyyts rpfyksldrv leahlrgaev lyslaaahar
      541 rsglagrypl sdftlltear rtlglfqhhd aitgtakeav vvdygvrllr slvnlkqvii
      601 haahylvlgd ketyhfdpea pflqvddtrl shdalpertv iqldssprfv vlfnpleqer
      661 fsmvsllvns prvrvlseeg qplavqisah wssateavpd vyqvsvpvrl palglgvlql
      721 qlgldghrtl pssvriylhg rqlsvsrhea fplrvidsgt sdfalsnrym qvwfsgltgl
      781 lksirrvdee heqqvdmqvl vygtrtskdk sgaylflpdg eakpyvpkep pvlrvtegpf
      841 fsevvayyeh ihqavrlynl pgveglsldi sslvdirdyv nkelalhiht didsqgifft
      901 dlngfqvqpr rylkklplqa nfypmpvmay iqdaqkrltl htaqalgvss lkdgqlevil
      961 drrlmqddnr glgqglkdnk rtcnrfrlll errtvgsepd ffsklaamfr glifhssrsg
     1021 nrevqdshst sypsllshlt smylnapala lpvarmqlpg pglrsfhpla sslpcdfhll
     1081 nlrtlqaeed tlpsaetali lhrkgfdcgl eaknlgfnct tsqgkvalgs lfhgldvvfl
     1141 qptsltllyp laspsnstdv ylepmeiatf rlrlg
//
LOCUS       XP_024305688            1175 aa            linear   PRI 05-AUG-2025
DEFINITION  alpha-mannosidase 2x isoform X1 [Homo sapiens].
ACCESSION   XP_024305688
VERSION     XP_024305688.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449920.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1175
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1175
                     /product="alpha-mannosidase 2x isoform X1"
                     /calculated_mol_wt=133261
     Region          136..1174
                     /region_name="PLN02701"
                     /note="alpha-mannosidase"
                     /db_xref="CDD:178304"
     CDS             1..1175
                     /gene="MAN2A2"
                     /gene_synonym="alpha-MIIx; MANA2X"
                     /coded_by="XM_024449920.2:532..4059"
                     /db_xref="GeneID:4122"
                     /db_xref="HGNC:HGNC:6825"
                     /db_xref="MIM:600988"
ORIGIN      
        1 mklkkqvtvc gaaifcvavf slylmldrvq hdptrhqngg nfprsqisvl qnrieqleql
       61 leenheiish ikdsvlelta naegppamlp yytvngswvv ppeprpsffs ispqdcqfal
      121 ggrgqkpelq mltvseelpf dnvdggvwrq gfdisydphd wdaedlqvfv vphshndpgw
      181 iktfdkyyte qtqhilnsmv sklqedprrr flwaevsffa kwwdninvqk raavrrlvgn
      241 gqleiatggw vmpdeanshy falidqlieg hqwlernlga tprsgwavdp fgysstmpyl
      301 lrranltsml iqrvhyaikk hfaathslef mwrqtwdsds stdifchmmp fysydvphtc
      361 gpdpkiccqf dfkrlpggri ncpwkvppra iteanvaera allldqyrkk sqlfrsnvll
      421 vplgddfryd kpqewdaqff nyqrlfdffn srpnlhvqaq fgtlsdyfda lykrtgvepg
      481 arppgfpvls gdffsyadre dhywtgyyts rpfyksldrv leahlrgaev lyslaaahar
      541 rsglagrypl sdftlltear rtlglfqhhd aitgtakeav vvdygvrllr slvnlkqvii
      601 haahylvlgd ketyhfdpea pflqvddtrl shdalpertv iqldssprfv vlfnpleqer
      661 fsmvsllvns prvrvlseeg qplavqisah wssateavpd vyqvsvpvrl palglgvlql
      721 qlgldghrtl pssvriylhg rqlsvsrhea fplrvidsgt sdfalsnrym qvwfsgltgl
      781 lksirrvdee heqqvdmqvl vygtrtskdk sgaylflpdg eakpyvpkep pvlrvtegpf
      841 fsevvayyeh ihqavrlynl pgveglsldi sslvdirdyv nkelalhiht didsqgifft
      901 dlngfqvqpr rylkklplqa nfypmpvmay iqdaqkrltl htaqalgvss lkdgqlevil
      961 drrlmqddnr glgqglkdnk rtcnrfrlll errtvgsepd ffsklaamfr glifhssrsg
     1021 nrevqdshst sypsllshlt smylnapala lpvarmqlpg pglrsfhpla sslpcdfhll
     1081 nlrtlqaeed tlpsaetali lhrkgfdcgl eaknlgfnct tsqgkvalgs lfhgldvvfl
     1141 qptsltllyp laspsnstdv ylepmeiatf rlrlg
//
LOCUS       XP_047288463            1175 aa            linear   PRI 05-AUG-2025
DEFINITION  alpha-mannosidase 2x isoform X1 [Homo sapiens].
ACCESSION   XP_047288463
VERSION     XP_047288463.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432507.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1175
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1175
                     /product="alpha-mannosidase 2x isoform X1"
                     /calculated_mol_wt=133261
     Region          136..1174
                     /region_name="PLN02701"
                     /note="alpha-mannosidase"
                     /db_xref="CDD:178304"
     CDS             1..1175
                     /gene="MAN2A2"
                     /gene_synonym="alpha-MIIx; MANA2X"
                     /coded_by="XM_047432507.1:575..4102"
                     /db_xref="GeneID:4122"
                     /db_xref="HGNC:HGNC:6825"
                     /db_xref="MIM:600988"
ORIGIN      
        1 mklkkqvtvc gaaifcvavf slylmldrvq hdptrhqngg nfprsqisvl qnrieqleql
       61 leenheiish ikdsvlelta naegppamlp yytvngswvv ppeprpsffs ispqdcqfal
      121 ggrgqkpelq mltvseelpf dnvdggvwrq gfdisydphd wdaedlqvfv vphshndpgw
      181 iktfdkyyte qtqhilnsmv sklqedprrr flwaevsffa kwwdninvqk raavrrlvgn
      241 gqleiatggw vmpdeanshy falidqlieg hqwlernlga tprsgwavdp fgysstmpyl
      301 lrranltsml iqrvhyaikk hfaathslef mwrqtwdsds stdifchmmp fysydvphtc
      361 gpdpkiccqf dfkrlpggri ncpwkvppra iteanvaera allldqyrkk sqlfrsnvll
      421 vplgddfryd kpqewdaqff nyqrlfdffn srpnlhvqaq fgtlsdyfda lykrtgvepg
      481 arppgfpvls gdffsyadre dhywtgyyts rpfyksldrv leahlrgaev lyslaaahar
      541 rsglagrypl sdftlltear rtlglfqhhd aitgtakeav vvdygvrllr slvnlkqvii
      601 haahylvlgd ketyhfdpea pflqvddtrl shdalpertv iqldssprfv vlfnpleqer
      661 fsmvsllvns prvrvlseeg qplavqisah wssateavpd vyqvsvpvrl palglgvlql
      721 qlgldghrtl pssvriylhg rqlsvsrhea fplrvidsgt sdfalsnrym qvwfsgltgl
      781 lksirrvdee heqqvdmqvl vygtrtskdk sgaylflpdg eakpyvpkep pvlrvtegpf
      841 fsevvayyeh ihqavrlynl pgveglsldi sslvdirdyv nkelalhiht didsqgifft
      901 dlngfqvqpr rylkklplqa nfypmpvmay iqdaqkrltl htaqalgvss lkdgqlevil
      961 drrlmqddnr glgqglkdnk rtcnrfrlll errtvgsepd ffsklaamfr glifhssrsg
     1021 nrevqdshst sypsllshlt smylnapala lpvarmqlpg pglrsfhpla sslpcdfhll
     1081 nlrtlqaeed tlpsaetali lhrkgfdcgl eaknlgfnct tsqgkvalgs lfhgldvvfl
     1141 qptsltllyp laspsnstdv ylepmeiatf rlrlg
//
LOCUS       XP_016877673            1175 aa            linear   PRI 05-AUG-2025
DEFINITION  alpha-mannosidase 2x isoform X1 [Homo sapiens].
ACCESSION   XP_016877673
VERSION     XP_016877673.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022184.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1175
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1175
                     /product="alpha-mannosidase 2x isoform X1"
                     /calculated_mol_wt=133261
     Region          136..1174
                     /region_name="PLN02701"
                     /note="alpha-mannosidase"
                     /db_xref="CDD:178304"
     CDS             1..1175
                     /gene="MAN2A2"
                     /gene_synonym="alpha-MIIx; MANA2X"
                     /coded_by="XM_017022184.2:203..3730"
                     /db_xref="GeneID:4122"
                     /db_xref="HGNC:HGNC:6825"
                     /db_xref="MIM:600988"
ORIGIN      
        1 mklkkqvtvc gaaifcvavf slylmldrvq hdptrhqngg nfprsqisvl qnrieqleql
       61 leenheiish ikdsvlelta naegppamlp yytvngswvv ppeprpsffs ispqdcqfal
      121 ggrgqkpelq mltvseelpf dnvdggvwrq gfdisydphd wdaedlqvfv vphshndpgw
      181 iktfdkyyte qtqhilnsmv sklqedprrr flwaevsffa kwwdninvqk raavrrlvgn
      241 gqleiatggw vmpdeanshy falidqlieg hqwlernlga tprsgwavdp fgysstmpyl
      301 lrranltsml iqrvhyaikk hfaathslef mwrqtwdsds stdifchmmp fysydvphtc
      361 gpdpkiccqf dfkrlpggri ncpwkvppra iteanvaera allldqyrkk sqlfrsnvll
      421 vplgddfryd kpqewdaqff nyqrlfdffn srpnlhvqaq fgtlsdyfda lykrtgvepg
      481 arppgfpvls gdffsyadre dhywtgyyts rpfyksldrv leahlrgaev lyslaaahar
      541 rsglagrypl sdftlltear rtlglfqhhd aitgtakeav vvdygvrllr slvnlkqvii
      601 haahylvlgd ketyhfdpea pflqvddtrl shdalpertv iqldssprfv vlfnpleqer
      661 fsmvsllvns prvrvlseeg qplavqisah wssateavpd vyqvsvpvrl palglgvlql
      721 qlgldghrtl pssvriylhg rqlsvsrhea fplrvidsgt sdfalsnrym qvwfsgltgl
      781 lksirrvdee heqqvdmqvl vygtrtskdk sgaylflpdg eakpyvpkep pvlrvtegpf
      841 fsevvayyeh ihqavrlynl pgveglsldi sslvdirdyv nkelalhiht didsqgifft
      901 dlngfqvqpr rylkklplqa nfypmpvmay iqdaqkrltl htaqalgvss lkdgqlevil
      961 drrlmqddnr glgqglkdnk rtcnrfrlll errtvgsepd ffsklaamfr glifhssrsg
     1021 nrevqdshst sypsllshlt smylnapala lpvarmqlpg pglrsfhpla sslpcdfhll
     1081 nlrtlqaeed tlpsaetali lhrkgfdcgl eaknlgfnct tsqgkvalgs lfhgldvvfl
     1141 qptsltllyp laspsnstdv ylepmeiatf rlrlg
//
LOCUS       XP_024305691            1150 aa            linear   PRI 05-AUG-2025
DEFINITION  alpha-mannosidase 2x isoform X2 [Homo sapiens].
ACCESSION   XP_024305691
VERSION     XP_024305691.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449923.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1150
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1150
                     /product="alpha-mannosidase 2x isoform X2"
                     /calculated_mol_wt=130408
     Region          136..1149
                     /region_name="PLN02701"
                     /note="alpha-mannosidase"
                     /db_xref="CDD:178304"
     CDS             1..1150
                     /gene="MAN2A2"
                     /gene_synonym="alpha-MIIx; MANA2X"
                     /coded_by="XM_024449923.2:366..3818"
                     /db_xref="GeneID:4122"
                     /db_xref="HGNC:HGNC:6825"
                     /db_xref="MIM:600988"
ORIGIN      
        1 mklkkqvtvc gaaifcvavf slylmldrvq hdptrhqngg nfprsqisvl qnrieqleql
       61 leenheiish ikdsvlelta naegppamlp yytvngswvv ppeprpsffs ispqdcqfal
      121 ggrgqkpelq mltvseelpf dnvdggvwrq gfdisydphd wdaedlqvfv vphshndpgw
      181 iktfdkyyte qtqhilnsmv sklqedprrr flwaevsffa kwwdninvqk raavrrlvgn
      241 gqleiatggw vmpdeanshy falidqlieg hqwlernlga tprsgwavdp fgysstmpyl
      301 lrranltsml iqrvhyaikk hfaathslef mwrqtwdsds stdifchmmp fysydvphtc
      361 gpdpkiccqf dfkrlpggri ncpwkvppra iteanvaera allldqyrkk sqlfrsnvll
      421 vplgddfryd kpqewdaqff nyqrlfdffn srpnlhvqaq fgtlsdyfda lykrtgvepg
      481 arppgfpvls gdffsyadre dhywtgyyts rpfyksldrv leahlrgaev lyslaaahar
      541 rsglagrypl sdftlltear rtlglfqhhd aitgtakeav vvdygvrllr slvnlkqvii
      601 haahylvlgd ketyhfdpea pflqvddtrl shdalpertv iqldssprfv vlfnpleqer
      661 fsmvsllvns prvrvlseeg qplavqisah wssateavpd vyqvsvpvrl palglgvlql
      721 qlgldghrtl pssvriylhg rqlsvsrhea fplrvidsgt sdfalsnrym qvwfsgltgl
      781 lksirrvdee heqqvdmqvl vygtrtskdk sgaylflpdg eakpyvpkep pvlrvtegpf
      841 fsevvayyeh ihqavrlynl pgveglsldi sslvdirdyv nkelalhiht didsqgifft
      901 dlngfqvqpr rylkklplqa nfypmpvmay iqdaqkrltl htaqalgvss lkdgqlevil
      961 drrlmqddnr glgqglkdnk rtcnrfrlll errtvgsevq dshstsypsl lshltsmyln
     1021 apalalpvar mqlpgpglrs fhplasslpc dfhllnlrtl qaeedtlpsa etalilhrkg
     1081 fdcgleaknl gfncttsqgk valgslfhgl dvvflqptsl tllyplasps nstdvylepm
     1141 eiatfrlrlg
//
LOCUS       XP_024305690            1150 aa            linear   PRI 05-AUG-2025
DEFINITION  alpha-mannosidase 2x isoform X2 [Homo sapiens].
ACCESSION   XP_024305690
VERSION     XP_024305690.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449922.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1150
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1150
                     /product="alpha-mannosidase 2x isoform X2"
                     /calculated_mol_wt=130408
     Region          136..1149
                     /region_name="PLN02701"
                     /note="alpha-mannosidase"
                     /db_xref="CDD:178304"
     CDS             1..1150
                     /gene="MAN2A2"
                     /gene_synonym="alpha-MIIx; MANA2X"
                     /coded_by="XM_024449922.2:532..3984"
                     /db_xref="GeneID:4122"
                     /db_xref="HGNC:HGNC:6825"
                     /db_xref="MIM:600988"
ORIGIN      
        1 mklkkqvtvc gaaifcvavf slylmldrvq hdptrhqngg nfprsqisvl qnrieqleql
       61 leenheiish ikdsvlelta naegppamlp yytvngswvv ppeprpsffs ispqdcqfal
      121 ggrgqkpelq mltvseelpf dnvdggvwrq gfdisydphd wdaedlqvfv vphshndpgw
      181 iktfdkyyte qtqhilnsmv sklqedprrr flwaevsffa kwwdninvqk raavrrlvgn
      241 gqleiatggw vmpdeanshy falidqlieg hqwlernlga tprsgwavdp fgysstmpyl
      301 lrranltsml iqrvhyaikk hfaathslef mwrqtwdsds stdifchmmp fysydvphtc
      361 gpdpkiccqf dfkrlpggri ncpwkvppra iteanvaera allldqyrkk sqlfrsnvll
      421 vplgddfryd kpqewdaqff nyqrlfdffn srpnlhvqaq fgtlsdyfda lykrtgvepg
      481 arppgfpvls gdffsyadre dhywtgyyts rpfyksldrv leahlrgaev lyslaaahar
      541 rsglagrypl sdftlltear rtlglfqhhd aitgtakeav vvdygvrllr slvnlkqvii
      601 haahylvlgd ketyhfdpea pflqvddtrl shdalpertv iqldssprfv vlfnpleqer
      661 fsmvsllvns prvrvlseeg qplavqisah wssateavpd vyqvsvpvrl palglgvlql
      721 qlgldghrtl pssvriylhg rqlsvsrhea fplrvidsgt sdfalsnrym qvwfsgltgl
      781 lksirrvdee heqqvdmqvl vygtrtskdk sgaylflpdg eakpyvpkep pvlrvtegpf
      841 fsevvayyeh ihqavrlynl pgveglsldi sslvdirdyv nkelalhiht didsqgifft
      901 dlngfqvqpr rylkklplqa nfypmpvmay iqdaqkrltl htaqalgvss lkdgqlevil
      961 drrlmqddnr glgqglkdnk rtcnrfrlll errtvgsevq dshstsypsl lshltsmyln
     1021 apalalpvar mqlpgpglrs fhplasslpc dfhllnlrtl qaeedtlpsa etalilhrkg
     1081 fdcgleaknl gfncttsqgk valgslfhgl dvvflqptsl tllyplasps nstdvylepm
     1141 eiatfrlrlg
//
LOCUS       XP_024305692            1150 aa            linear   PRI 05-AUG-2025
DEFINITION  alpha-mannosidase 2x isoform X2 [Homo sapiens].
ACCESSION   XP_024305692
VERSION     XP_024305692.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449924.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1150
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1150
                     /product="alpha-mannosidase 2x isoform X2"
                     /calculated_mol_wt=130408
     Region          136..1149
                     /region_name="PLN02701"
                     /note="alpha-mannosidase"
                     /db_xref="CDD:178304"
     CDS             1..1150
                     /gene="MAN2A2"
                     /gene_synonym="alpha-MIIx; MANA2X"
                     /coded_by="XM_024449924.2:330..3782"
                     /db_xref="GeneID:4122"
                     /db_xref="HGNC:HGNC:6825"
                     /db_xref="MIM:600988"
ORIGIN      
        1 mklkkqvtvc gaaifcvavf slylmldrvq hdptrhqngg nfprsqisvl qnrieqleql
       61 leenheiish ikdsvlelta naegppamlp yytvngswvv ppeprpsffs ispqdcqfal
      121 ggrgqkpelq mltvseelpf dnvdggvwrq gfdisydphd wdaedlqvfv vphshndpgw
      181 iktfdkyyte qtqhilnsmv sklqedprrr flwaevsffa kwwdninvqk raavrrlvgn
      241 gqleiatggw vmpdeanshy falidqlieg hqwlernlga tprsgwavdp fgysstmpyl
      301 lrranltsml iqrvhyaikk hfaathslef mwrqtwdsds stdifchmmp fysydvphtc
      361 gpdpkiccqf dfkrlpggri ncpwkvppra iteanvaera allldqyrkk sqlfrsnvll
      421 vplgddfryd kpqewdaqff nyqrlfdffn srpnlhvqaq fgtlsdyfda lykrtgvepg
      481 arppgfpvls gdffsyadre dhywtgyyts rpfyksldrv leahlrgaev lyslaaahar
      541 rsglagrypl sdftlltear rtlglfqhhd aitgtakeav vvdygvrllr slvnlkqvii
      601 haahylvlgd ketyhfdpea pflqvddtrl shdalpertv iqldssprfv vlfnpleqer
      661 fsmvsllvns prvrvlseeg qplavqisah wssateavpd vyqvsvpvrl palglgvlql
      721 qlgldghrtl pssvriylhg rqlsvsrhea fplrvidsgt sdfalsnrym qvwfsgltgl
      781 lksirrvdee heqqvdmqvl vygtrtskdk sgaylflpdg eakpyvpkep pvlrvtegpf
      841 fsevvayyeh ihqavrlynl pgveglsldi sslvdirdyv nkelalhiht didsqgifft
      901 dlngfqvqpr rylkklplqa nfypmpvmay iqdaqkrltl htaqalgvss lkdgqlevil
      961 drrlmqddnr glgqglkdnk rtcnrfrlll errtvgsevq dshstsypsl lshltsmyln
     1021 apalalpvar mqlpgpglrs fhplasslpc dfhllnlrtl qaeedtlpsa etalilhrkg
     1081 fdcgleaknl gfncttsqgk valgslfhgl dvvflqptsl tllyplasps nstdvylepm
     1141 eiatfrlrlg
//
LOCUS       XP_016877674            1150 aa            linear   PRI 05-AUG-2025
DEFINITION  alpha-mannosidase 2x isoform X2 [Homo sapiens].
ACCESSION   XP_016877674
VERSION     XP_016877674.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022185.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1150
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1150
                     /product="alpha-mannosidase 2x isoform X2"
                     /calculated_mol_wt=130408
     Region          136..1149
                     /region_name="PLN02701"
                     /note="alpha-mannosidase"
                     /db_xref="CDD:178304"
     CDS             1..1150
                     /gene="MAN2A2"
                     /gene_synonym="alpha-MIIx; MANA2X"
                     /coded_by="XM_017022185.2:164..3616"
                     /db_xref="GeneID:4122"
                     /db_xref="HGNC:HGNC:6825"
                     /db_xref="MIM:600988"
ORIGIN      
        1 mklkkqvtvc gaaifcvavf slylmldrvq hdptrhqngg nfprsqisvl qnrieqleql
       61 leenheiish ikdsvlelta naegppamlp yytvngswvv ppeprpsffs ispqdcqfal
      121 ggrgqkpelq mltvseelpf dnvdggvwrq gfdisydphd wdaedlqvfv vphshndpgw
      181 iktfdkyyte qtqhilnsmv sklqedprrr flwaevsffa kwwdninvqk raavrrlvgn
      241 gqleiatggw vmpdeanshy falidqlieg hqwlernlga tprsgwavdp fgysstmpyl
      301 lrranltsml iqrvhyaikk hfaathslef mwrqtwdsds stdifchmmp fysydvphtc
      361 gpdpkiccqf dfkrlpggri ncpwkvppra iteanvaera allldqyrkk sqlfrsnvll
      421 vplgddfryd kpqewdaqff nyqrlfdffn srpnlhvqaq fgtlsdyfda lykrtgvepg
      481 arppgfpvls gdffsyadre dhywtgyyts rpfyksldrv leahlrgaev lyslaaahar
      541 rsglagrypl sdftlltear rtlglfqhhd aitgtakeav vvdygvrllr slvnlkqvii
      601 haahylvlgd ketyhfdpea pflqvddtrl shdalpertv iqldssprfv vlfnpleqer
      661 fsmvsllvns prvrvlseeg qplavqisah wssateavpd vyqvsvpvrl palglgvlql
      721 qlgldghrtl pssvriylhg rqlsvsrhea fplrvidsgt sdfalsnrym qvwfsgltgl
      781 lksirrvdee heqqvdmqvl vygtrtskdk sgaylflpdg eakpyvpkep pvlrvtegpf
      841 fsevvayyeh ihqavrlynl pgveglsldi sslvdirdyv nkelalhiht didsqgifft
      901 dlngfqvqpr rylkklplqa nfypmpvmay iqdaqkrltl htaqalgvss lkdgqlevil
      961 drrlmqddnr glgqglkdnk rtcnrfrlll errtvgsevq dshstsypsl lshltsmyln
     1021 apalalpvar mqlpgpglrs fhplasslpc dfhllnlrtl qaeedtlpsa etalilhrkg
     1081 fdcgleaknl gfncttsqgk valgslfhgl dvvflqptsl tllyplasps nstdvylepm
     1141 eiatfrlrlg
//
LOCUS       XP_047288464            1150 aa            linear   PRI 05-AUG-2025
DEFINITION  alpha-mannosidase 2x isoform X2 [Homo sapiens].
ACCESSION   XP_047288464
VERSION     XP_047288464.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432508.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1150
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1150
                     /product="alpha-mannosidase 2x isoform X2"
                     /calculated_mol_wt=130408
     Region          136..1149
                     /region_name="PLN02701"
                     /note="alpha-mannosidase"
                     /db_xref="CDD:178304"
     CDS             1..1150
                     /gene="MAN2A2"
                     /gene_synonym="alpha-MIIx; MANA2X"
                     /coded_by="XM_047432508.1:575..4027"
                     /db_xref="GeneID:4122"
                     /db_xref="HGNC:HGNC:6825"
                     /db_xref="MIM:600988"
ORIGIN      
        1 mklkkqvtvc gaaifcvavf slylmldrvq hdptrhqngg nfprsqisvl qnrieqleql
       61 leenheiish ikdsvlelta naegppamlp yytvngswvv ppeprpsffs ispqdcqfal
      121 ggrgqkpelq mltvseelpf dnvdggvwrq gfdisydphd wdaedlqvfv vphshndpgw
      181 iktfdkyyte qtqhilnsmv sklqedprrr flwaevsffa kwwdninvqk raavrrlvgn
      241 gqleiatggw vmpdeanshy falidqlieg hqwlernlga tprsgwavdp fgysstmpyl
      301 lrranltsml iqrvhyaikk hfaathslef mwrqtwdsds stdifchmmp fysydvphtc
      361 gpdpkiccqf dfkrlpggri ncpwkvppra iteanvaera allldqyrkk sqlfrsnvll
      421 vplgddfryd kpqewdaqff nyqrlfdffn srpnlhvqaq fgtlsdyfda lykrtgvepg
      481 arppgfpvls gdffsyadre dhywtgyyts rpfyksldrv leahlrgaev lyslaaahar
      541 rsglagrypl sdftlltear rtlglfqhhd aitgtakeav vvdygvrllr slvnlkqvii
      601 haahylvlgd ketyhfdpea pflqvddtrl shdalpertv iqldssprfv vlfnpleqer
      661 fsmvsllvns prvrvlseeg qplavqisah wssateavpd vyqvsvpvrl palglgvlql
      721 qlgldghrtl pssvriylhg rqlsvsrhea fplrvidsgt sdfalsnrym qvwfsgltgl
      781 lksirrvdee heqqvdmqvl vygtrtskdk sgaylflpdg eakpyvpkep pvlrvtegpf
      841 fsevvayyeh ihqavrlynl pgveglsldi sslvdirdyv nkelalhiht didsqgifft
      901 dlngfqvqpr rylkklplqa nfypmpvmay iqdaqkrltl htaqalgvss lkdgqlevil
      961 drrlmqddnr glgqglkdnk rtcnrfrlll errtvgsevq dshstsypsl lshltsmyln
     1021 apalalpvar mqlpgpglrs fhplasslpc dfhllnlrtl qaeedtlpsa etalilhrkg
     1081 fdcgleaknl gfncttsqgk valgslfhgl dvvflqptsl tllyplasps nstdvylepm
     1141 eiatfrlrlg
//
LOCUS       XP_047288465            1150 aa            linear   PRI 05-AUG-2025
DEFINITION  alpha-mannosidase 2x isoform X2 [Homo sapiens].
ACCESSION   XP_047288465
VERSION     XP_047288465.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432509.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1150
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1150
                     /product="alpha-mannosidase 2x isoform X2"
                     /calculated_mol_wt=130408
     Region          136..1149
                     /region_name="PLN02701"
                     /note="alpha-mannosidase"
                     /db_xref="CDD:178304"
     CDS             1..1150
                     /gene="MAN2A2"
                     /gene_synonym="alpha-MIIx; MANA2X"
                     /coded_by="XM_047432509.1:585..4037"
                     /db_xref="GeneID:4122"
                     /db_xref="HGNC:HGNC:6825"
                     /db_xref="MIM:600988"
ORIGIN      
        1 mklkkqvtvc gaaifcvavf slylmldrvq hdptrhqngg nfprsqisvl qnrieqleql
       61 leenheiish ikdsvlelta naegppamlp yytvngswvv ppeprpsffs ispqdcqfal
      121 ggrgqkpelq mltvseelpf dnvdggvwrq gfdisydphd wdaedlqvfv vphshndpgw
      181 iktfdkyyte qtqhilnsmv sklqedprrr flwaevsffa kwwdninvqk raavrrlvgn
      241 gqleiatggw vmpdeanshy falidqlieg hqwlernlga tprsgwavdp fgysstmpyl
      301 lrranltsml iqrvhyaikk hfaathslef mwrqtwdsds stdifchmmp fysydvphtc
      361 gpdpkiccqf dfkrlpggri ncpwkvppra iteanvaera allldqyrkk sqlfrsnvll
      421 vplgddfryd kpqewdaqff nyqrlfdffn srpnlhvqaq fgtlsdyfda lykrtgvepg
      481 arppgfpvls gdffsyadre dhywtgyyts rpfyksldrv leahlrgaev lyslaaahar
      541 rsglagrypl sdftlltear rtlglfqhhd aitgtakeav vvdygvrllr slvnlkqvii
      601 haahylvlgd ketyhfdpea pflqvddtrl shdalpertv iqldssprfv vlfnpleqer
      661 fsmvsllvns prvrvlseeg qplavqisah wssateavpd vyqvsvpvrl palglgvlql
      721 qlgldghrtl pssvriylhg rqlsvsrhea fplrvidsgt sdfalsnrym qvwfsgltgl
      781 lksirrvdee heqqvdmqvl vygtrtskdk sgaylflpdg eakpyvpkep pvlrvtegpf
      841 fsevvayyeh ihqavrlynl pgveglsldi sslvdirdyv nkelalhiht didsqgifft
      901 dlngfqvqpr rylkklplqa nfypmpvmay iqdaqkrltl htaqalgvss lkdgqlevil
      961 drrlmqddnr glgqglkdnk rtcnrfrlll errtvgsevq dshstsypsl lshltsmyln
     1021 apalalpvar mqlpgpglrs fhplasslpc dfhllnlrtl qaeedtlpsa etalilhrkg
     1081 fdcgleaknl gfncttsqgk valgslfhgl dvvflqptsl tllyplasps nstdvylepm
     1141 eiatfrlrlg
//
LOCUS       XP_047288466            1150 aa            linear   PRI 05-AUG-2025
DEFINITION  alpha-mannosidase 2x isoform X2 [Homo sapiens].
ACCESSION   XP_047288466
VERSION     XP_047288466.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432510.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1150
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1150
                     /product="alpha-mannosidase 2x isoform X2"
                     /calculated_mol_wt=130408
     Region          136..1149
                     /region_name="PLN02701"
                     /note="alpha-mannosidase"
                     /db_xref="CDD:178304"
     CDS             1..1150
                     /gene="MAN2A2"
                     /gene_synonym="alpha-MIIx; MANA2X"
                     /coded_by="XM_047432510.1:419..3871"
                     /db_xref="GeneID:4122"
                     /db_xref="HGNC:HGNC:6825"
                     /db_xref="MIM:600988"
ORIGIN      
        1 mklkkqvtvc gaaifcvavf slylmldrvq hdptrhqngg nfprsqisvl qnrieqleql
       61 leenheiish ikdsvlelta naegppamlp yytvngswvv ppeprpsffs ispqdcqfal
      121 ggrgqkpelq mltvseelpf dnvdggvwrq gfdisydphd wdaedlqvfv vphshndpgw
      181 iktfdkyyte qtqhilnsmv sklqedprrr flwaevsffa kwwdninvqk raavrrlvgn
      241 gqleiatggw vmpdeanshy falidqlieg hqwlernlga tprsgwavdp fgysstmpyl
      301 lrranltsml iqrvhyaikk hfaathslef mwrqtwdsds stdifchmmp fysydvphtc
      361 gpdpkiccqf dfkrlpggri ncpwkvppra iteanvaera allldqyrkk sqlfrsnvll
      421 vplgddfryd kpqewdaqff nyqrlfdffn srpnlhvqaq fgtlsdyfda lykrtgvepg
      481 arppgfpvls gdffsyadre dhywtgyyts rpfyksldrv leahlrgaev lyslaaahar
      541 rsglagrypl sdftlltear rtlglfqhhd aitgtakeav vvdygvrllr slvnlkqvii
      601 haahylvlgd ketyhfdpea pflqvddtrl shdalpertv iqldssprfv vlfnpleqer
      661 fsmvsllvns prvrvlseeg qplavqisah wssateavpd vyqvsvpvrl palglgvlql
      721 qlgldghrtl pssvriylhg rqlsvsrhea fplrvidsgt sdfalsnrym qvwfsgltgl
      781 lksirrvdee heqqvdmqvl vygtrtskdk sgaylflpdg eakpyvpkep pvlrvtegpf
      841 fsevvayyeh ihqavrlynl pgveglsldi sslvdirdyv nkelalhiht didsqgifft
      901 dlngfqvqpr rylkklplqa nfypmpvmay iqdaqkrltl htaqalgvss lkdgqlevil
      961 drrlmqddnr glgqglkdnk rtcnrfrlll errtvgsevq dshstsypsl lshltsmyln
     1021 apalalpvar mqlpgpglrs fhplasslpc dfhllnlrtl qaeedtlpsa etalilhrkg
     1081 fdcgleaknl gfncttsqgk valgslfhgl dvvflqptsl tllyplasps nstdvylepm
     1141 eiatfrlrlg
//
LOCUS       XP_047288467            1003 aa            linear   PRI 05-AUG-2025
DEFINITION  alpha-mannosidase 2x isoform X3 [Homo sapiens].
ACCESSION   XP_047288467
VERSION     XP_047288467.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432511.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1003
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1003
                     /product="alpha-mannosidase 2x isoform X3"
                     /calculated_mol_wt=114390
     Region          136..999
                     /region_name="PLN02701"
                     /note="alpha-mannosidase"
                     /db_xref="CDD:178304"
     CDS             1..1003
                     /gene="MAN2A2"
                     /gene_synonym="alpha-MIIx; MANA2X"
                     /coded_by="XM_047432511.1:150..3161"
                     /db_xref="GeneID:4122"
                     /db_xref="HGNC:HGNC:6825"
                     /db_xref="MIM:600988"
ORIGIN      
        1 mklkkqvtvc gaaifcvavf slylmldrvq hdptrhqngg nfprsqisvl qnrieqleql
       61 leenheiish ikdsvlelta naegppamlp yytvngswvv ppeprpsffs ispqdcqfal
      121 ggrgqkpelq mltvseelpf dnvdggvwrq gfdisydphd wdaedlqvfv vphshndpgw
      181 iktfdkyyte qtqhilnsmv sklqedprrr flwaevsffa kwwdninvqk raavrrlvgn
      241 gqleiatggw vmpdeanshy falidqlieg hqwlernlga tprsgwavdp fgysstmpyl
      301 lrranltsml iqrvhyaikk hfaathslef mwrqtwdsds stdifchmmp fysydvphtc
      361 gpdpkiccqf dfkrlpggri ncpwkvppra iteanvaera allldqyrkk sqlfrsnvll
      421 vplgddfryd kpqewdaqff nyqrlfdffn srpnlhvqaq fgtlsdyfda lykrtgvepg
      481 arppgfpvls gdffsyadre dhywtgyyts rpfyksldrv leahlrgaev lyslaaahar
      541 rsglagrypl sdftlltear rtlglfqhhd aitgtakeav vvdygvrllr slvnlkqvii
      601 haahylvlgd ketyhfdpea pflqvddtrl shdalpertv iqldssprfv vlfnpleqer
      661 fsmvsllvns prvrvlseeg qplavqisah wssateavpd vyqvsvpvrl palglgvlql
      721 qlgldghrtl pssvriylhg rqlsvsrhea fplrvidsgt sdfalsnrym qvwfsgltgl
      781 lksirrvdee heqqvdmqvl vygtrtskdk sgaylflpdg eakpyvpkep pvlrvtegpf
      841 fsevvayyeh ihqavrlynl pgveglsldi sslvdirdyv nkelalhiht didsqgifft
      901 dlngfqvqpr rylkklplqa nfypmpvmay iqdaqkrltl htaqalgvss lkdgqlevil
      961 drrlmqddnr glgqglkdnk rtcnrfrlll errtvgsepc lga
//
LOCUS       XP_047288468             938 aa            linear   PRI 05-AUG-2025
DEFINITION  alpha-mannosidase 2x isoform X4 [Homo sapiens].
ACCESSION   XP_047288468
VERSION     XP_047288468.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432512.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..938
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..938
                     /product="alpha-mannosidase 2x isoform X4"
                     /calculated_mol_wt=106304
     Region          136..>896
                     /region_name="PLN02701"
                     /note="alpha-mannosidase"
                     /db_xref="CDD:178304"
     Region          165..508
                     /region_name="GH38-57_N_LamB_YdjC_SF"
                     /note="Catalytic domain of glycoside hydrolase (GH)
                     families 38 and 57, lactam utilization protein LamB/YcsF
                     family proteins, YdjC-family proteins, and similar
                     proteins; cl49606"
                     /db_xref="CDD:483946"
     CDS             1..938
                     /gene="MAN2A2"
                     /gene_synonym="alpha-MIIx; MANA2X"
                     /coded_by="XM_047432512.1:150..2966"
                     /db_xref="GeneID:4122"
                     /db_xref="HGNC:HGNC:6825"
                     /db_xref="MIM:600988"
ORIGIN      
        1 mklkkqvtvc gaaifcvavf slylmldrvq hdptrhqngg nfprsqisvl qnrieqleql
       61 leenheiish ikdsvlelta naegppamlp yytvngswvv ppeprpsffs ispqdcqfal
      121 ggrgqkpelq mltvseelpf dnvdggvwrq gfdisydphd wdaedlqvfv vphshndpgw
      181 iktfdkyyte qtqhilnsmv sklqedprrr flwaevsffa kwwdninvqk raavrrlvgn
      241 gqleiatggw vmpdeanshy falidqlieg hqwlernlga tprsgwavdp fgysstmpyl
      301 lrranltsml iqrvhyaikk hfaathslef mwrqtwdsds stdifchmmp fysydvphtc
      361 gpdpkiccqf dfkrlpggri ncpwkvppra iteanvaera allldqyrkk sqlfrsnvll
      421 vplgddfryd kpqewdaqff nyqrlfdffn srpnlhvqaq fgtlsdyfda lykrtgvepg
      481 arppgfpvls gdffsyadre dhywtgyyts rpfyksldrv leahlrgaev lyslaaahar
      541 rsglagrypl sdftlltear rtlglfqhhd aitgtakeav vvdygvrllr slvnlkqvii
      601 haahylvlgd ketyhfdpea pflqvddtrl shdalpertv iqldssprfv vlfnpleqer
      661 fsmvsllvns prvrvlseeg qplavqisah wssateavpd vyqvsvpvrl palglgvlql
      721 qlgldghrtl pssvriylhg rqlsvsrhea fplrvidsgt sdfalsnrym qvwfsgltgl
      781 lksirrvdee heqqvdmqvl vygtrtskdk sgaylflpdg eakpyvpkep pvlrvtegpf
      841 fsevvayyeh ihqavrlynl pgveglsldi sslvdirdyv nkelalhiht didsqgaapt
      901 vseeapppgq llphashgly pgrteaphaa hcpgpgcl
//
LOCUS       XP_047288469             796 aa            linear   PRI 05-AUG-2025
DEFINITION  alpha-mannosidase 2x isoform X5 [Homo sapiens].
ACCESSION   XP_047288469
VERSION     XP_047288469.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432513.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..796
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..796
                     /product="alpha-mannosidase 2x isoform X5"
                     /calculated_mol_wt=90561
     Region          165..508
                     /region_name="GH38-57_N_LamB_YdjC_SF"
                     /note="Catalytic domain of glycoside hydrolase (GH)
                     families 38 and 57, lactam utilization protein LamB/YcsF
                     family proteins, YdjC-family proteins, and similar
                     proteins; cl49606"
                     /db_xref="CDD:483946"
     Region          502..606
                     /region_name="Alpha-mann_mid"
                     /note="Alpha mannosidase middle domain; pfam09261"
                     /db_xref="CDD:462728"
     CDS             1..796
                     /gene="MAN2A2"
                     /gene_synonym="alpha-MIIx; MANA2X"
                     /coded_by="XM_047432513.1:150..2540"
                     /db_xref="GeneID:4122"
                     /db_xref="HGNC:HGNC:6825"
                     /db_xref="MIM:600988"
ORIGIN      
        1 mklkkqvtvc gaaifcvavf slylmldrvq hdptrhqngg nfprsqisvl qnrieqleql
       61 leenheiish ikdsvlelta naegppamlp yytvngswvv ppeprpsffs ispqdcqfal
      121 ggrgqkpelq mltvseelpf dnvdggvwrq gfdisydphd wdaedlqvfv vphshndpgw
      181 iktfdkyyte qtqhilnsmv sklqedprrr flwaevsffa kwwdninvqk raavrrlvgn
      241 gqleiatggw vmpdeanshy falidqlieg hqwlernlga tprsgwavdp fgysstmpyl
      301 lrranltsml iqrvhyaikk hfaathslef mwrqtwdsds stdifchmmp fysydvphtc
      361 gpdpkiccqf dfkrlpggri ncpwkvppra iteanvaera allldqyrkk sqlfrsnvll
      421 vplgddfryd kpqewdaqff nyqrlfdffn srpnlhvqaq fgtlsdyfda lykrtgvepg
      481 arppgfpvls gdffsyadre dhywtgyyts rpfyksldrv leahlrgaev lyslaaahar
      541 rsglagrypl sdftlltear rtlglfqhhd aitgtakeav vvdygvrllr slvnlkqvii
      601 haahylvlgd ketyhfdpea pflqvddtrl shdalpertv iqldssprfv vlfnpleqer
      661 fsmvsllvns prvrvlseeg qplavqisah wssateavpd vyqvsvpvrl palglgvlql
      721 qlgldghrtl pssvriylhg rqlsvsrhea fplrvidsgt sdfalsnrym qvwfsgltgl
      781 lkgsglcfla ehpkgg
//
LOCUS       XP_047288470             785 aa            linear   PRI 05-AUG-2025
DEFINITION  alpha-mannosidase 2x isoform X6 [Homo sapiens].
ACCESSION   XP_047288470
VERSION     XP_047288470.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432514.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..785
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..785
                     /product="alpha-mannosidase 2x isoform X6"
                     /calculated_mol_wt=89359
     Region          165..508
                     /region_name="GH38-57_N_LamB_YdjC_SF"
                     /note="Catalytic domain of glycoside hydrolase (GH)
                     families 38 and 57, lactam utilization protein LamB/YcsF
                     family proteins, YdjC-family proteins, and similar
                     proteins; cl49606"
                     /db_xref="CDD:483946"
     Region          502..606
                     /region_name="Alpha-mann_mid"
                     /note="Alpha mannosidase middle domain; pfam09261"
                     /db_xref="CDD:462728"
     CDS             1..785
                     /gene="MAN2A2"
                     /gene_synonym="alpha-MIIx; MANA2X"
                     /coded_by="XM_047432514.1:150..2507"
                     /db_xref="GeneID:4122"
                     /db_xref="HGNC:HGNC:6825"
                     /db_xref="MIM:600988"
ORIGIN      
        1 mklkkqvtvc gaaifcvavf slylmldrvq hdptrhqngg nfprsqisvl qnrieqleql
       61 leenheiish ikdsvlelta naegppamlp yytvngswvv ppeprpsffs ispqdcqfal
      121 ggrgqkpelq mltvseelpf dnvdggvwrq gfdisydphd wdaedlqvfv vphshndpgw
      181 iktfdkyyte qtqhilnsmv sklqedprrr flwaevsffa kwwdninvqk raavrrlvgn
      241 gqleiatggw vmpdeanshy falidqlieg hqwlernlga tprsgwavdp fgysstmpyl
      301 lrranltsml iqrvhyaikk hfaathslef mwrqtwdsds stdifchmmp fysydvphtc
      361 gpdpkiccqf dfkrlpggri ncpwkvppra iteanvaera allldqyrkk sqlfrsnvll
      421 vplgddfryd kpqewdaqff nyqrlfdffn srpnlhvqaq fgtlsdyfda lykrtgvepg
      481 arppgfpvls gdffsyadre dhywtgyyts rpfyksldrv leahlrgaev lyslaaahar
      541 rsglagrypl sdftlltear rtlglfqhhd aitgtakeav vvdygvrllr slvnlkqvii
      601 haahylvlgd ketyhfdpea pflqvddtrl shdalpertv iqldssprfv vlfnpleqer
      661 fsmvsllvns prvrvlseeg qplavqisah wssateavpd vyqvsvpvrl palglgvlql
      721 qlgldghrtl pssvriylhg rqlsvsrhea fplrvidsgt sdfalsnrym qgsglcflae
      781 hpkgg
//
LOCUS       XP_047288471             754 aa            linear   PRI 05-AUG-2025
DEFINITION  alpha-mannosidase 2x isoform X7 [Homo sapiens].
ACCESSION   XP_047288471
VERSION     XP_047288471.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432515.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..754
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..754
                     /product="alpha-mannosidase 2x isoform X7"
                     /calculated_mol_wt=83239
     Region          <105..753
                     /region_name="PLN02701"
                     /note="alpha-mannosidase"
                     /db_xref="CDD:178304"
     CDS             1..754
                     /gene="MAN2A2"
                     /gene_synonym="alpha-MIIx; MANA2X"
                     /coded_by="XM_047432515.1:223..2487"
                     /db_xref="GeneID:4122"
                     /db_xref="HGNC:HGNC:6825"
                     /db_xref="MIM:600988"
ORIGIN      
        1 mtspipvaqi prsaanlisn aclvgastal grchpgpsqr ptwqrgqpcf wtntgrspsc
       61 seatsswcll emtsdmtspr sgmpsssttn gsltsstagl tsmcrgaevl yslaaaharr
      121 sglagrypls dftlltearr tlglfqhhda itgtakeavv vdygvrllrs lvnlkqviih
      181 aahylvlgdk etyhfdpeap flqvddtrls hdalpertvi qldssprfvv lfnpleqerf
      241 smvsllvnsp rvrvlseegq plavqisahw ssateavpdv yqvsvpvrlp alglgvlqlq
      301 lgldghrtlp ssvriylhgr qlsvsrheaf plrvidsgts dfalsnrymq vwfsgltgll
      361 ksirrvdeeh eqqvdmqvlv ygtrtskdks gaylflpdge akpyvpkepp vlrvtegpff
      421 sevvayyehi hqavrlynlp gveglsldis slvdirdyvn kelalhihtd idsqgifftd
      481 lngfqvqprr ylkklplqan fypmpvmayi qdaqkrltlh taqalgvssl kdgqlevild
      541 rrlmqddnrg lgqglkdnkr tcnrfrllle rrtvgsepdf fsklaamfrg lifhssrsgn
      601 revqdshsts ypsllshlts mylnapalal pvarmqlpgp glrsfhplas slpcdfhlln
      661 lrtlqaeedt lpsaetalil hrkgfdcgle aknlgfnctt sqgkvalgsl fhgldvvflq
      721 ptsltllypl aspsnstdvy lepmeiatfr lrlg
//
LOCUS       XP_047288472             729 aa            linear   PRI 05-AUG-2025
DEFINITION  alpha-mannosidase 2x isoform X8 [Homo sapiens].
ACCESSION   XP_047288472
VERSION     XP_047288472.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432516.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..729
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..729
                     /product="alpha-mannosidase 2x isoform X8"
                     /calculated_mol_wt=80386
     Region          <105..728
                     /region_name="PLN02701"
                     /note="alpha-mannosidase"
                     /db_xref="CDD:178304"
     CDS             1..729
                     /gene="MAN2A2"
                     /gene_synonym="alpha-MIIx; MANA2X"
                     /coded_by="XM_047432516.1:223..2412"
                     /db_xref="GeneID:4122"
                     /db_xref="HGNC:HGNC:6825"
                     /db_xref="MIM:600988"
ORIGIN      
        1 mtspipvaqi prsaanlisn aclvgastal grchpgpsqr ptwqrgqpcf wtntgrspsc
       61 seatsswcll emtsdmtspr sgmpsssttn gsltsstagl tsmcrgaevl yslaaaharr
      121 sglagrypls dftlltearr tlglfqhhda itgtakeavv vdygvrllrs lvnlkqviih
      181 aahylvlgdk etyhfdpeap flqvddtrls hdalpertvi qldssprfvv lfnpleqerf
      241 smvsllvnsp rvrvlseegq plavqisahw ssateavpdv yqvsvpvrlp alglgvlqlq
      301 lgldghrtlp ssvriylhgr qlsvsrheaf plrvidsgts dfalsnrymq vwfsgltgll
      361 ksirrvdeeh eqqvdmqvlv ygtrtskdks gaylflpdge akpyvpkepp vlrvtegpff
      421 sevvayyehi hqavrlynlp gveglsldis slvdirdyvn kelalhihtd idsqgifftd
      481 lngfqvqprr ylkklplqan fypmpvmayi qdaqkrltlh taqalgvssl kdgqlevild
      541 rrlmqddnrg lgqglkdnkr tcnrfrllle rrtvgsevqd shstsypsll shltsmylna
      601 palalpvarm qlpgpglrsf hplasslpcd fhllnlrtlq aeedtlpsae talilhrkgf
      661 dcgleaknlg fncttsqgkv algslfhgld vvflqptslt llyplaspsn stdvylepme
      721 iatfrlrlg
//
LOCUS       XP_011519874             511 aa            linear   PRI 05-AUG-2025
DEFINITION  myocyte-specific enhancer factor 2A isoform X1 [Homo sapiens].
ACCESSION   XP_011519874
VERSION     XP_011519874.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521572.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..511
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..511
                     /product="myocyte-specific enhancer factor 2A isoform X1"
                     /calculated_mol_wt=55096
     Region          2..78
                     /region_name="MADS_MEF2_like"
                     /note="MEF2 (myocyte enhancer factor 2)-like/Type II
                     subfamily of MADS (MCM1, Agamous, Deficiens, and SRF
                     (serum response factor) box family of eukaryotic
                     transcriptional regulators. Binds DNA and exists as hetero
                     and homo-dimers. Differs from SRF-like/Type I...; cd00265"
                     /db_xref="CDD:238165"
     Site            order(2..4,6,8,13,15,19..20,23..24,26..27,30..31,33..34,
                     38)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238165"
     Site            order(21,28..29,32..33,35..36,39,44,46,48,54,56,62,65..66,
                     69,72..73)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:238165"
     Site            59
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:238165"
     Region          97..158
                     /region_name="HJURP_C"
                     /note="Holliday junction regulator protein family
                     C-terminal repeat; pfam12347"
                     /db_xref="CDD:463543"
     CDS             1..511
                     /gene="MEF2A"
                     /gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
                     /coded_by="XM_011521572.3:478..2013"
                     /db_xref="GeneID:4205"
                     /db_xref="HGNC:HGNC:6993"
                     /db_xref="MIM:600660"
ORIGIN      
        1 mgrkkiqitr imdernrqvt ftkrkfglmk kayelsvlcd ceialiifns snklfqyast
       61 dmdkvllkyt eynephesrt nsdivealnk kehrgcdspd pdtsyvltph teekykkine
      121 efdnmmrnhk iavstkpglp pqnfsmsvtv pvtspnalsy tnpgsslvsp slaasstltd
      181 ssmlsppqtt lhrnvspgap qrppstgnag gmlsttdltv pngagsspvg ngfvnsrasp
      241 nligatgans lgkvmptksp pppgggnlgm nsrkpdlrvv ippsskgmmp plseeeelel
      301 ntqrisssqa tqplatpvvs vttpslppqg lvysamptay ntdysltsad lsalqgfnsp
      361 gmlslgqvsa wqqhhlgqaa lsslvaggql sqgsnlsint nqnisiksep ispprdrmtp
      421 sgfqqqqqqq qqqqpppppq pqpqppqpqp rqemgrspvd slssssssyd gsdredprgd
      481 fhspivlgrp pntedresps vkrmrmdawv t
//
LOCUS       XP_011519875             511 aa            linear   PRI 05-AUG-2025
DEFINITION  myocyte-specific enhancer factor 2A isoform X1 [Homo sapiens].
ACCESSION   XP_011519875
VERSION     XP_011519875.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521573.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..511
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..511
                     /product="myocyte-specific enhancer factor 2A isoform X1"
                     /calculated_mol_wt=55096
     Region          2..78
                     /region_name="MADS_MEF2_like"
                     /note="MEF2 (myocyte enhancer factor 2)-like/Type II
                     subfamily of MADS (MCM1, Agamous, Deficiens, and SRF
                     (serum response factor) box family of eukaryotic
                     transcriptional regulators. Binds DNA and exists as hetero
                     and homo-dimers. Differs from SRF-like/Type I...; cd00265"
                     /db_xref="CDD:238165"
     Site            order(2..4,6,8,13,15,19..20,23..24,26..27,30..31,33..34,
                     38)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238165"
     Site            order(21,28..29,32..33,35..36,39,44,46,48,54,56,62,65..66,
                     69,72..73)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:238165"
     Site            59
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:238165"
     Region          97..158
                     /region_name="HJURP_C"
                     /note="Holliday junction regulator protein family
                     C-terminal repeat; pfam12347"
                     /db_xref="CDD:463543"
     CDS             1..511
                     /gene="MEF2A"
                     /gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
                     /coded_by="XM_011521573.3:342..1877"
                     /db_xref="GeneID:4205"
                     /db_xref="HGNC:HGNC:6993"
                     /db_xref="MIM:600660"
ORIGIN      
        1 mgrkkiqitr imdernrqvt ftkrkfglmk kayelsvlcd ceialiifns snklfqyast
       61 dmdkvllkyt eynephesrt nsdivealnk kehrgcdspd pdtsyvltph teekykkine
      121 efdnmmrnhk iavstkpglp pqnfsmsvtv pvtspnalsy tnpgsslvsp slaasstltd
      181 ssmlsppqtt lhrnvspgap qrppstgnag gmlsttdltv pngagsspvg ngfvnsrasp
      241 nligatgans lgkvmptksp pppgggnlgm nsrkpdlrvv ippsskgmmp plseeeelel
      301 ntqrisssqa tqplatpvvs vttpslppqg lvysamptay ntdysltsad lsalqgfnsp
      361 gmlslgqvsa wqqhhlgqaa lsslvaggql sqgsnlsint nqnisiksep ispprdrmtp
      421 sgfqqqqqqq qqqqpppppq pqpqppqpqp rqemgrspvd slssssssyd gsdredprgd
      481 fhspivlgrp pntedresps vkrmrmdawv t
//
LOCUS       XP_011519879             511 aa            linear   PRI 05-AUG-2025
DEFINITION  myocyte-specific enhancer factor 2A isoform X1 [Homo sapiens].
ACCESSION   XP_011519879
VERSION     XP_011519879.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521577.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..511
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..511
                     /product="myocyte-specific enhancer factor 2A isoform X1"
                     /calculated_mol_wt=55096
     Region          2..78
                     /region_name="MADS_MEF2_like"
                     /note="MEF2 (myocyte enhancer factor 2)-like/Type II
                     subfamily of MADS (MCM1, Agamous, Deficiens, and SRF
                     (serum response factor) box family of eukaryotic
                     transcriptional regulators. Binds DNA and exists as hetero
                     and homo-dimers. Differs from SRF-like/Type I...; cd00265"
                     /db_xref="CDD:238165"
     Site            order(2..4,6,8,13,15,19..20,23..24,26..27,30..31,33..34,
                     38)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238165"
     Site            order(21,28..29,32..33,35..36,39,44,46,48,54,56,62,65..66,
                     69,72..73)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:238165"
     Site            59
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:238165"
     Region          97..158
                     /region_name="HJURP_C"
                     /note="Holliday junction regulator protein family
                     C-terminal repeat; pfam12347"
                     /db_xref="CDD:463543"
     CDS             1..511
                     /gene="MEF2A"
                     /gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
                     /coded_by="XM_011521577.3:360..1895"
                     /db_xref="GeneID:4205"
                     /db_xref="HGNC:HGNC:6993"
                     /db_xref="MIM:600660"
ORIGIN      
        1 mgrkkiqitr imdernrqvt ftkrkfglmk kayelsvlcd ceialiifns snklfqyast
       61 dmdkvllkyt eynephesrt nsdivealnk kehrgcdspd pdtsyvltph teekykkine
      121 efdnmmrnhk iavstkpglp pqnfsmsvtv pvtspnalsy tnpgsslvsp slaasstltd
      181 ssmlsppqtt lhrnvspgap qrppstgnag gmlsttdltv pngagsspvg ngfvnsrasp
      241 nligatgans lgkvmptksp pppgggnlgm nsrkpdlrvv ippsskgmmp plseeeelel
      301 ntqrisssqa tqplatpvvs vttpslppqg lvysamptay ntdysltsad lsalqgfnsp
      361 gmlslgqvsa wqqhhlgqaa lsslvaggql sqgsnlsint nqnisiksep ispprdrmtp
      421 sgfqqqqqqq qqqqpppppq pqpqppqpqp rqemgrspvd slssssssyd gsdredprgd
      481 fhspivlgrp pntedresps vkrmrmdawv t
//
LOCUS       XP_011519881             511 aa            linear   PRI 05-AUG-2025
DEFINITION  myocyte-specific enhancer factor 2A isoform X1 [Homo sapiens].
ACCESSION   XP_011519881
VERSION     XP_011519881.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521579.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..511
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..511
                     /product="myocyte-specific enhancer factor 2A isoform X1"
                     /calculated_mol_wt=55096
     Region          2..78
                     /region_name="MADS_MEF2_like"
                     /note="MEF2 (myocyte enhancer factor 2)-like/Type II
                     subfamily of MADS (MCM1, Agamous, Deficiens, and SRF
                     (serum response factor) box family of eukaryotic
                     transcriptional regulators. Binds DNA and exists as hetero
                     and homo-dimers. Differs from SRF-like/Type I...; cd00265"
                     /db_xref="CDD:238165"
     Site            order(2..4,6,8,13,15,19..20,23..24,26..27,30..31,33..34,
                     38)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238165"
     Site            order(21,28..29,32..33,35..36,39,44,46,48,54,56,62,65..66,
                     69,72..73)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:238165"
     Site            59
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:238165"
     Region          97..158
                     /region_name="HJURP_C"
                     /note="Holliday junction regulator protein family
                     C-terminal repeat; pfam12347"
                     /db_xref="CDD:463543"
     CDS             1..511
                     /gene="MEF2A"
                     /gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
                     /coded_by="XM_011521579.3:396..1931"
                     /db_xref="GeneID:4205"
                     /db_xref="HGNC:HGNC:6993"
                     /db_xref="MIM:600660"
ORIGIN      
        1 mgrkkiqitr imdernrqvt ftkrkfglmk kayelsvlcd ceialiifns snklfqyast
       61 dmdkvllkyt eynephesrt nsdivealnk kehrgcdspd pdtsyvltph teekykkine
      121 efdnmmrnhk iavstkpglp pqnfsmsvtv pvtspnalsy tnpgsslvsp slaasstltd
      181 ssmlsppqtt lhrnvspgap qrppstgnag gmlsttdltv pngagsspvg ngfvnsrasp
      241 nligatgans lgkvmptksp pppgggnlgm nsrkpdlrvv ippsskgmmp plseeeelel
      301 ntqrisssqa tqplatpvvs vttpslppqg lvysamptay ntdysltsad lsalqgfnsp
      361 gmlslgqvsa wqqhhlgqaa lsslvaggql sqgsnlsint nqnisiksep ispprdrmtp
      421 sgfqqqqqqq qqqqpppppq pqpqppqpqp rqemgrspvd slssssssyd gsdredprgd
      481 fhspivlgrp pntedresps vkrmrmdawv t
//
LOCUS       XP_047288475             511 aa            linear   PRI 05-AUG-2025
DEFINITION  myocyte-specific enhancer factor 2A isoform X1 [Homo sapiens].
ACCESSION   XP_047288475
VERSION     XP_047288475.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432519.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..511
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..511
                     /product="myocyte-specific enhancer factor 2A isoform X1"
                     /calculated_mol_wt=55096
     Region          2..78
                     /region_name="MADS_MEF2_like"
                     /note="MEF2 (myocyte enhancer factor 2)-like/Type II
                     subfamily of MADS (MCM1, Agamous, Deficiens, and SRF
                     (serum response factor) box family of eukaryotic
                     transcriptional regulators. Binds DNA and exists as hetero
                     and homo-dimers. Differs from SRF-like/Type I...; cd00265"
                     /db_xref="CDD:238165"
     Site            order(2..4,6,8,13,15,19..20,23..24,26..27,30..31,33..34,
                     38)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238165"
     Site            order(21,28..29,32..33,35..36,39,44,46,48,54,56,62,65..66,
                     69,72..73)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:238165"
     Site            59
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:238165"
     Region          97..158
                     /region_name="HJURP_C"
                     /note="Holliday junction regulator protein family
                     C-terminal repeat; pfam12347"
                     /db_xref="CDD:463543"
     CDS             1..511
                     /gene="MEF2A"
                     /gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
                     /coded_by="XM_047432519.1:260..1795"
                     /db_xref="GeneID:4205"
                     /db_xref="HGNC:HGNC:6993"
                     /db_xref="MIM:600660"
ORIGIN      
        1 mgrkkiqitr imdernrqvt ftkrkfglmk kayelsvlcd ceialiifns snklfqyast
       61 dmdkvllkyt eynephesrt nsdivealnk kehrgcdspd pdtsyvltph teekykkine
      121 efdnmmrnhk iavstkpglp pqnfsmsvtv pvtspnalsy tnpgsslvsp slaasstltd
      181 ssmlsppqtt lhrnvspgap qrppstgnag gmlsttdltv pngagsspvg ngfvnsrasp
      241 nligatgans lgkvmptksp pppgggnlgm nsrkpdlrvv ippsskgmmp plseeeelel
      301 ntqrisssqa tqplatpvvs vttpslppqg lvysamptay ntdysltsad lsalqgfnsp
      361 gmlslgqvsa wqqhhlgqaa lsslvaggql sqgsnlsint nqnisiksep ispprdrmtp
      421 sgfqqqqqqq qqqqpppppq pqpqppqpqp rqemgrspvd slssssssyd gsdredprgd
      481 fhspivlgrp pntedresps vkrmrmdawv t
//
LOCUS       XP_047288476             511 aa            linear   PRI 05-AUG-2025
DEFINITION  myocyte-specific enhancer factor 2A isoform X1 [Homo sapiens].
ACCESSION   XP_047288476
VERSION     XP_047288476.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432520.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..511
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..511
                     /product="myocyte-specific enhancer factor 2A isoform X1"
                     /calculated_mol_wt=55096
     Region          2..78
                     /region_name="MADS_MEF2_like"
                     /note="MEF2 (myocyte enhancer factor 2)-like/Type II
                     subfamily of MADS (MCM1, Agamous, Deficiens, and SRF
                     (serum response factor) box family of eukaryotic
                     transcriptional regulators. Binds DNA and exists as hetero
                     and homo-dimers. Differs from SRF-like/Type I...; cd00265"
                     /db_xref="CDD:238165"
     Site            order(2..4,6,8,13,15,19..20,23..24,26..27,30..31,33..34,
                     38)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238165"
     Site            order(21,28..29,32..33,35..36,39,44,46,48,54,56,62,65..66,
                     69,72..73)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:238165"
     Site            59
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:238165"
     Region          97..158
                     /region_name="HJURP_C"
                     /note="Holliday junction regulator protein family
                     C-terminal repeat; pfam12347"
                     /db_xref="CDD:463543"
     CDS             1..511
                     /gene="MEF2A"
                     /gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
                     /coded_by="XM_047432520.1:451..1986"
                     /db_xref="GeneID:4205"
                     /db_xref="HGNC:HGNC:6993"
                     /db_xref="MIM:600660"
ORIGIN      
        1 mgrkkiqitr imdernrqvt ftkrkfglmk kayelsvlcd ceialiifns snklfqyast
       61 dmdkvllkyt eynephesrt nsdivealnk kehrgcdspd pdtsyvltph teekykkine
      121 efdnmmrnhk iavstkpglp pqnfsmsvtv pvtspnalsy tnpgsslvsp slaasstltd
      181 ssmlsppqtt lhrnvspgap qrppstgnag gmlsttdltv pngagsspvg ngfvnsrasp
      241 nligatgans lgkvmptksp pppgggnlgm nsrkpdlrvv ippsskgmmp plseeeelel
      301 ntqrisssqa tqplatpvvs vttpslppqg lvysamptay ntdysltsad lsalqgfnsp
      361 gmlslgqvsa wqqhhlgqaa lsslvaggql sqgsnlsint nqnisiksep ispprdrmtp
      421 sgfqqqqqqq qqqqpppppq pqpqppqpqp rqemgrspvd slssssssyd gsdredprgd
      481 fhspivlgrp pntedresps vkrmrmdawv t
//
LOCUS       XP_011519884             507 aa            linear   PRI 05-AUG-2025
DEFINITION  myocyte-specific enhancer factor 2A isoform X2 [Homo sapiens].
ACCESSION   XP_011519884
VERSION     XP_011519884.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521582.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..507
                     /product="myocyte-specific enhancer factor 2A isoform X2"
                     /calculated_mol_wt=54681
     Region          2..78
                     /region_name="MADS_MEF2_like"
                     /note="MEF2 (myocyte enhancer factor 2)-like/Type II
                     subfamily of MADS (MCM1, Agamous, Deficiens, and SRF
                     (serum response factor) box family of eukaryotic
                     transcriptional regulators. Binds DNA and exists as hetero
                     and homo-dimers. Differs from SRF-like/Type I...; cd00265"
                     /db_xref="CDD:238165"
     Site            order(2..4,6,8,13,15,19..20,23..24,26..27,30..31,33..34,
                     38)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238165"
     Site            order(21,28..29,32..33,35..36,39,44,46,48,54,56,62,65..66,
                     69,72..73)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:238165"
     Site            59
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:238165"
     Region          97..154
                     /region_name="HJURP_C"
                     /note="Holliday junction regulator protein family
                     C-terminal repeat; pfam12347"
                     /db_xref="CDD:463543"
     CDS             1..507
                     /gene="MEF2A"
                     /gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
                     /coded_by="XM_011521582.3:563..2086"
                     /db_xref="GeneID:4205"
                     /db_xref="HGNC:HGNC:6993"
                     /db_xref="MIM:600660"
ORIGIN      
        1 mgrkkiqitr imdernrqvt ftkrkfglmk kayelsvlcd ceialiifns snklfqyast
       61 dmdkvllkyt eynephesrt nsdivealnk kehrgcdspd pdtsyvltph teekykkine
      121 efdnmmrnhk iapglppqnf smsvtvpvts pnalsytnpg sslvspslaa sstltdssml
      181 sppqttlhrn vspgapqrpp stgnaggmls ttdltvpnga gsspvgngfv nsraspnlig
      241 atganslgkv mptksppppg ggnlgmnsrk pdlrvvipps skgmmpplse eeelelntqr
      301 isssqatqpl atpvvsvttp slppqglvys amptayntdy sltsadlsal qgfnspgmls
      361 lgqvsawqqh hlgqaalssl vaggqlsqgs nlsintnqni siksepispp rdrmtpsgfq
      421 qqqqqqqqqq pppppqpqpq ppqpqprqem grspvdslss ssssydgsdr edprgdfhsp
      481 ivlgrppnte drespsvkrm rmdawvt
//
LOCUS       XP_047288477             507 aa            linear   PRI 05-AUG-2025
DEFINITION  myocyte-specific enhancer factor 2A isoform X2 [Homo sapiens].
ACCESSION   XP_047288477
VERSION     XP_047288477.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432521.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..507
                     /product="myocyte-specific enhancer factor 2A isoform X2"
                     /calculated_mol_wt=54681
     Region          2..78
                     /region_name="MADS_MEF2_like"
                     /note="MEF2 (myocyte enhancer factor 2)-like/Type II
                     subfamily of MADS (MCM1, Agamous, Deficiens, and SRF
                     (serum response factor) box family of eukaryotic
                     transcriptional regulators. Binds DNA and exists as hetero
                     and homo-dimers. Differs from SRF-like/Type I...; cd00265"
                     /db_xref="CDD:238165"
     Site            order(2..4,6,8,13,15,19..20,23..24,26..27,30..31,33..34,
                     38)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238165"
     Site            order(21,28..29,32..33,35..36,39,44,46,48,54,56,62,65..66,
                     69,72..73)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:238165"
     Site            59
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:238165"
     Region          97..154
                     /region_name="HJURP_C"
                     /note="Holliday junction regulator protein family
                     C-terminal repeat; pfam12347"
                     /db_xref="CDD:463543"
     CDS             1..507
                     /gene="MEF2A"
                     /gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
                     /coded_by="XM_047432521.1:451..1974"
                     /db_xref="GeneID:4205"
                     /db_xref="HGNC:HGNC:6993"
                     /db_xref="MIM:600660"
ORIGIN      
        1 mgrkkiqitr imdernrqvt ftkrkfglmk kayelsvlcd ceialiifns snklfqyast
       61 dmdkvllkyt eynephesrt nsdivealnk kehrgcdspd pdtsyvltph teekykkine
      121 efdnmmrnhk iapglppqnf smsvtvpvts pnalsytnpg sslvspslaa sstltdssml
      181 sppqttlhrn vspgapqrpp stgnaggmls ttdltvpnga gsspvgngfv nsraspnlig
      241 atganslgkv mptksppppg ggnlgmnsrk pdlrvvipps skgmmpplse eeelelntqr
      301 isssqatqpl atpvvsvttp slppqglvys amptayntdy sltsadlsal qgfnspgmls
      361 lgqvsawqqh hlgqaalssl vaggqlsqgs nlsintnqni siksepispp rdrmtpsgfq
      421 qqqqqqqqqq pppppqpqpq ppqpqprqem grspvdslss ssssydgsdr edprgdfhsp
      481 ivlgrppnte drespsvkrm rmdawvt
//
LOCUS       XP_047288478             505 aa            linear   PRI 05-AUG-2025
DEFINITION  myocyte-specific enhancer factor 2A isoform X3 [Homo sapiens].
ACCESSION   XP_047288478
VERSION     XP_047288478.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432522.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..505
                     /product="myocyte-specific enhancer factor 2A isoform X3"
                     /calculated_mol_wt=54311
     Region          1..>235
                     /region_name="ARG80"
                     /note="Regulator of arginine metabolism and related MADS
                     box-containing transcription factors [Transcription];
                     COG5068"
                     /db_xref="CDD:227400"
     Region          2..78
                     /region_name="MADS_MEF2_like"
                     /note="MEF2 (myocyte enhancer factor 2)-like/Type II
                     subfamily of MADS (MCM1, Agamous, Deficiens, and SRF
                     (serum response factor) box family of eukaryotic
                     transcriptional regulators. Binds DNA and exists as hetero
                     and homo-dimers. Differs from SRF-like/Type I...; cd00265"
                     /db_xref="CDD:238165"
     Site            order(2..4,6,8,13,15,19..20,23..24,26..27,30..31,33..34,
                     38)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238165"
     Site            order(21,28..29,32..33,35..36,39,44,46,48,54,56,62,65..66,
                     69,72..73)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:238165"
     Site            59
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:238165"
     CDS             1..505
                     /gene="MEF2A"
                     /gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
                     /coded_by="XM_047432522.1:360..1877"
                     /db_xref="GeneID:4205"
                     /db_xref="HGNC:HGNC:6993"
                     /db_xref="MIM:600660"
ORIGIN      
        1 mgrkkiqitr imdernrqvt ftkrkfglmk kayelsvlcd ceialiifns snklfqyast
       61 dmdkvllkyt eynephesrt nsdivetlrk kglngcespd addyfehspl sedrfsklne
      121 dsdfifkrgp pglppqnfsm svtvpvtspn alsytnpgss lvspslaass tltdssmlsp
      181 pqttlhrnvs pgapqrppst gnaggmlstt dltvpngags spvgngfvns raspnligat
      241 ganslgkvmp tksppppggg nlgmnsrkpd lrvvippssk gmmpplseee elelntqris
      301 ssqatqplat pvvsvttpsl ppqglvysam ptayntdysl tsadlsalqg fnspgmlslg
      361 qvsawqqhhl gqaalsslva ggqlsqgsnl sintnqnisi ksepispprd rmtpsgfqqq
      421 qqqqqqqqpp pppqpqpqpp qpqprqemgr spvdslssss ssydgsdred prgdfhspiv
      481 lgrppntedr espsvkrmrm dawvt
//
LOCUS       XP_047288479             503 aa            linear   PRI 05-AUG-2025
DEFINITION  myocyte-specific enhancer factor 2A isoform X4 [Homo sapiens].
ACCESSION   XP_047288479
VERSION     XP_047288479.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432523.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..503
                     /product="myocyte-specific enhancer factor 2A isoform X4"
                     /calculated_mol_wt=54137
     Region          2..78
                     /region_name="MADS_MEF2_like"
                     /note="MEF2 (myocyte enhancer factor 2)-like/Type II
                     subfamily of MADS (MCM1, Agamous, Deficiens, and SRF
                     (serum response factor) box family of eukaryotic
                     transcriptional regulators. Binds DNA and exists as hetero
                     and homo-dimers. Differs from SRF-like/Type I...; cd00265"
                     /db_xref="CDD:238165"
     Site            order(2..4,6,8,13,15,19..20,23..24,26..27,30..31,33..34,
                     38)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238165"
     Site            order(21,28..29,32..33,35..36,39,44,46,48,54,56,62,65..66,
                     69,72..73)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:238165"
     Site            59
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:238165"
     Region          97..158
                     /region_name="HJURP_C"
                     /note="Holliday junction regulator protein family
                     C-terminal repeat; pfam12347"
                     /db_xref="CDD:463543"
     CDS             1..503
                     /gene="MEF2A"
                     /gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
                     /coded_by="XM_047432523.1:451..1962"
                     /db_xref="GeneID:4205"
                     /db_xref="HGNC:HGNC:6993"
                     /db_xref="MIM:600660"
ORIGIN      
        1 mgrkkiqitr imdernrqvt ftkrkfglmk kayelsvlcd ceialiifns snklfqyast
       61 dmdkvllkyt eynephesrt nsdivealnk kehrgcdspd pdtsyvltph teekykkine
      121 efdnmmrnhk iavstkpglp pqnfsmsvtv pvtspnalsy tnpgsslvsp slaasstltd
      181 ssmlsppqtt lhrnvspgap qrppstgnag gmlsttdltv pngagsspvg ngfvnsrasp
      241 nligatgans lgkvmptksp pppgggnlgm nsrkpdlrvv ippsskgmmp plntqrisss
      301 qatqplatpv vsvttpslpp qglvysampt ayntdyslts adlsalqgfn spgmlslgqv
      361 sawqqhhlgq aalsslvagg qlsqgsnlsi ntnqnisiks epispprdrm tpsgfqqqqq
      421 qqqqqqpppp pqpqpqppqp qprqemgrsp vdslssssss ydgsdredpr gdfhspivlg
      481 rppntedres psvkrmrmda wvt
//
LOCUS       XP_047288480             499 aa            linear   PRI 05-AUG-2025
DEFINITION  myocyte-specific enhancer factor 2A isoform X5 [Homo sapiens].
ACCESSION   XP_047288480
VERSION     XP_047288480.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432524.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..499
                     /product="myocyte-specific enhancer factor 2A isoform X5"
                     /calculated_mol_wt=53722
     Region          2..78
                     /region_name="MADS_MEF2_like"
                     /note="MEF2 (myocyte enhancer factor 2)-like/Type II
                     subfamily of MADS (MCM1, Agamous, Deficiens, and SRF
                     (serum response factor) box family of eukaryotic
                     transcriptional regulators. Binds DNA and exists as hetero
                     and homo-dimers. Differs from SRF-like/Type I...; cd00265"
                     /db_xref="CDD:238165"
     Site            order(2..4,6,8,13,15,19..20,23..24,26..27,30..31,33..34,
                     38)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238165"
     Site            order(21,28..29,32..33,35..36,39,44,46,48,54,56,62,65..66,
                     69,72..73)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:238165"
     Site            59
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:238165"
     Region          97..154
                     /region_name="HJURP_C"
                     /note="Holliday junction regulator protein family
                     C-terminal repeat; pfam12347"
                     /db_xref="CDD:463543"
     CDS             1..499
                     /gene="MEF2A"
                     /gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
                     /coded_by="XM_047432524.1:360..1859"
                     /db_xref="GeneID:4205"
                     /db_xref="HGNC:HGNC:6993"
                     /db_xref="MIM:600660"
ORIGIN      
        1 mgrkkiqitr imdernrqvt ftkrkfglmk kayelsvlcd ceialiifns snklfqyast
       61 dmdkvllkyt eynephesrt nsdivealnk kehrgcdspd pdtsyvltph teekykkine
      121 efdnmmrnhk iapglppqnf smsvtvpvts pnalsytnpg sslvspslaa sstltdssml
      181 sppqttlhrn vspgapqrpp stgnaggmls ttdltvpnga gsspvgngfv nsraspnlig
      241 atganslgkv mptksppppg ggnlgmnsrk pdlrvvipps skgmmpplnt qrisssqatq
      301 platpvvsvt tpslppqglv ysamptaynt dysltsadls alqgfnspgm lslgqvsawq
      361 qhhlgqaals slvaggqlsq gsnlsintnq nisiksepis pprdrmtpsg fqqqqqqqqq
      421 qqpppppqpq pqppqpqprq emgrspvdsl ssssssydgs dredprgdfh spivlgrppn
      481 tedrespsvk rmrmdawvt
//
LOCUS       XP_047288481             497 aa            linear   PRI 05-AUG-2025
DEFINITION  myocyte-specific enhancer factor 2A isoform X6 [Homo sapiens].
ACCESSION   XP_047288481
VERSION     XP_047288481.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432525.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..497
                     /product="myocyte-specific enhancer factor 2A isoform X6"
                     /calculated_mol_wt=53352
     Region          1..>235
                     /region_name="ARG80"
                     /note="Regulator of arginine metabolism and related MADS
                     box-containing transcription factors [Transcription];
                     COG5068"
                     /db_xref="CDD:227400"
     Region          2..78
                     /region_name="MADS_MEF2_like"
                     /note="MEF2 (myocyte enhancer factor 2)-like/Type II
                     subfamily of MADS (MCM1, Agamous, Deficiens, and SRF
                     (serum response factor) box family of eukaryotic
                     transcriptional regulators. Binds DNA and exists as hetero
                     and homo-dimers. Differs from SRF-like/Type I...; cd00265"
                     /db_xref="CDD:238165"
     Site            order(2..4,6,8,13,15,19..20,23..24,26..27,30..31,33..34,
                     38)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238165"
     Site            order(21,28..29,32..33,35..36,39,44,46,48,54,56,62,65..66,
                     69,72..73)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:238165"
     Site            59
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:238165"
     CDS             1..497
                     /gene="MEF2A"
                     /gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
                     /coded_by="XM_047432525.1:360..1853"
                     /db_xref="GeneID:4205"
                     /db_xref="HGNC:HGNC:6993"
                     /db_xref="MIM:600660"
ORIGIN      
        1 mgrkkiqitr imdernrqvt ftkrkfglmk kayelsvlcd ceialiifns snklfqyast
       61 dmdkvllkyt eynephesrt nsdivetlrk kglngcespd addyfehspl sedrfsklne
      121 dsdfifkrgp pglppqnfsm svtvpvtspn alsytnpgss lvspslaass tltdssmlsp
      181 pqttlhrnvs pgapqrppst gnaggmlstt dltvpngags spvgngfvns raspnligat
      241 ganslgkvmp tksppppggg nlgmnsrkpd lrvvippssk gmmpplntqr isssqatqpl
      301 atpvvsvttp slppqglvys amptayntdy sltsadlsal qgfnspgmls lgqvsawqqh
      361 hlgqaalssl vaggqlsqgs nlsintnqni siksepispp rdrmtpsgfq qqqqqqqqqq
      421 pppppqpqpq ppqpqprqem grspvdslss ssssydgsdr edprgdfhsp ivlgrppnte
      481 drespsvkrm rmdawvt
//
LOCUS       XP_047288482             507 aa            linear   PRI 05-AUG-2025
DEFINITION  myocyte-specific enhancer factor 2A isoform X2 [Homo sapiens].
ACCESSION   XP_047288482
VERSION     XP_047288482.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432526.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..507
                     /product="myocyte-specific enhancer factor 2A isoform X2"
                     /calculated_mol_wt=54681
     Region          2..78
                     /region_name="MADS_MEF2_like"
                     /note="MEF2 (myocyte enhancer factor 2)-like/Type II
                     subfamily of MADS (MCM1, Agamous, Deficiens, and SRF
                     (serum response factor) box family of eukaryotic
                     transcriptional regulators. Binds DNA and exists as hetero
                     and homo-dimers. Differs from SRF-like/Type I...; cd00265"
                     /db_xref="CDD:238165"
     Site            order(2..4,6,8,13,15,19..20,23..24,26..27,30..31,33..34,
                     38)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238165"
     Site            order(21,28..29,32..33,35..36,39,44,46,48,54,56,62,65..66,
                     69,72..73)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:238165"
     Site            59
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:238165"
     Region          97..154
                     /region_name="HJURP_C"
                     /note="Holliday junction regulator protein family
                     C-terminal repeat; pfam12347"
                     /db_xref="CDD:463543"
     CDS             1..507
                     /gene="MEF2A"
                     /gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
                     /coded_by="XM_047432526.1:260..1783"
                     /db_xref="GeneID:4205"
                     /db_xref="HGNC:HGNC:6993"
                     /db_xref="MIM:600660"
ORIGIN      
        1 mgrkkiqitr imdernrqvt ftkrkfglmk kayelsvlcd ceialiifns snklfqyast
       61 dmdkvllkyt eynephesrt nsdivealnk kehrgcdspd pdtsyvltph teekykkine
      121 efdnmmrnhk iapglppqnf smsvtvpvts pnalsytnpg sslvspslaa sstltdssml
      181 sppqttlhrn vspgapqrpp stgnaggmls ttdltvpnga gsspvgngfv nsraspnlig
      241 atganslgkv mptksppppg ggnlgmnsrk pdlrvvipps skgmmpplse eeelelntqr
      301 isssqatqpl atpvvsvttp slppqglvys amptayntdy sltsadlsal qgfnspgmls
      361 lgqvsawqqh hlgqaalssl vaggqlsqgs nlsintnqni siksepispp rdrmtpsgfq
      421 qqqqqqqqqq pppppqpqpq ppqpqprqem grspvdslss ssssydgsdr edprgdfhsp
      481 ivlgrppnte drespsvkrm rmdawvt
//
LOCUS       XP_047288483             503 aa            linear   PRI 05-AUG-2025
DEFINITION  myocyte-specific enhancer factor 2A isoform X4 [Homo sapiens].
ACCESSION   XP_047288483
VERSION     XP_047288483.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432527.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..503
                     /product="myocyte-specific enhancer factor 2A isoform X4"
                     /calculated_mol_wt=54137
     Region          2..78
                     /region_name="MADS_MEF2_like"
                     /note="MEF2 (myocyte enhancer factor 2)-like/Type II
                     subfamily of MADS (MCM1, Agamous, Deficiens, and SRF
                     (serum response factor) box family of eukaryotic
                     transcriptional regulators. Binds DNA and exists as hetero
                     and homo-dimers. Differs from SRF-like/Type I...; cd00265"
                     /db_xref="CDD:238165"
     Site            order(2..4,6,8,13,15,19..20,23..24,26..27,30..31,33..34,
                     38)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238165"
     Site            order(21,28..29,32..33,35..36,39,44,46,48,54,56,62,65..66,
                     69,72..73)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:238165"
     Site            59
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:238165"
     Region          97..158
                     /region_name="HJURP_C"
                     /note="Holliday junction regulator protein family
                     C-terminal repeat; pfam12347"
                     /db_xref="CDD:463543"
     CDS             1..503
                     /gene="MEF2A"
                     /gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
                     /coded_by="XM_047432527.1:342..1853"
                     /db_xref="GeneID:4205"
                     /db_xref="HGNC:HGNC:6993"
                     /db_xref="MIM:600660"
ORIGIN      
        1 mgrkkiqitr imdernrqvt ftkrkfglmk kayelsvlcd ceialiifns snklfqyast
       61 dmdkvllkyt eynephesrt nsdivealnk kehrgcdspd pdtsyvltph teekykkine
      121 efdnmmrnhk iavstkpglp pqnfsmsvtv pvtspnalsy tnpgsslvsp slaasstltd
      181 ssmlsppqtt lhrnvspgap qrppstgnag gmlsttdltv pngagsspvg ngfvnsrasp
      241 nligatgans lgkvmptksp pppgggnlgm nsrkpdlrvv ippsskgmmp plntqrisss
      301 qatqplatpv vsvttpslpp qglvysampt ayntdyslts adlsalqgfn spgmlslgqv
      361 sawqqhhlgq aalsslvagg qlsqgsnlsi ntnqnisiks epispprdrm tpsgfqqqqq
      421 qqqqqqpppp pqpqpqppqp qprqemgrsp vdslssssss ydgsdredpr gdfhspivlg
      481 rppntedres psvkrmrmda wvt
//
LOCUS       XP_047288484             499 aa            linear   PRI 05-AUG-2025
DEFINITION  myocyte-specific enhancer factor 2A isoform X5 [Homo sapiens].
ACCESSION   XP_047288484
VERSION     XP_047288484.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432528.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..499
                     /product="myocyte-specific enhancer factor 2A isoform X5"
                     /calculated_mol_wt=53722
     Region          2..78
                     /region_name="MADS_MEF2_like"
                     /note="MEF2 (myocyte enhancer factor 2)-like/Type II
                     subfamily of MADS (MCM1, Agamous, Deficiens, and SRF
                     (serum response factor) box family of eukaryotic
                     transcriptional regulators. Binds DNA and exists as hetero
                     and homo-dimers. Differs from SRF-like/Type I...; cd00265"
                     /db_xref="CDD:238165"
     Site            order(2..4,6,8,13,15,19..20,23..24,26..27,30..31,33..34,
                     38)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238165"
     Site            order(21,28..29,32..33,35..36,39,44,46,48,54,56,62,65..66,
                     69,72..73)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:238165"
     Site            59
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:238165"
     Region          97..154
                     /region_name="HJURP_C"
                     /note="Holliday junction regulator protein family
                     C-terminal repeat; pfam12347"
                     /db_xref="CDD:463543"
     CDS             1..499
                     /gene="MEF2A"
                     /gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
                     /coded_by="XM_047432528.1:439..1938"
                     /db_xref="GeneID:4205"
                     /db_xref="HGNC:HGNC:6993"
                     /db_xref="MIM:600660"
ORIGIN      
        1 mgrkkiqitr imdernrqvt ftkrkfglmk kayelsvlcd ceialiifns snklfqyast
       61 dmdkvllkyt eynephesrt nsdivealnk kehrgcdspd pdtsyvltph teekykkine
      121 efdnmmrnhk iapglppqnf smsvtvpvts pnalsytnpg sslvspslaa sstltdssml
      181 sppqttlhrn vspgapqrpp stgnaggmls ttdltvpnga gsspvgngfv nsraspnlig
      241 atganslgkv mptksppppg ggnlgmnsrk pdlrvvipps skgmmpplnt qrisssqatq
      301 platpvvsvt tpslppqglv ysamptaynt dysltsadls alqgfnspgm lslgqvsawq
      361 qhhlgqaals slvaggqlsq gsnlsintnq nisiksepis pprdrmtpsg fqqqqqqqqq
      421 qqpppppqpq pqppqpqprq emgrspvdsl ssssssydgs dredprgdfh spivlgrppn
      481 tedrespsvk rmrmdawvt
//
LOCUS       XP_047288485             499 aa            linear   PRI 05-AUG-2025
DEFINITION  myocyte-specific enhancer factor 2A isoform X5 [Homo sapiens].
ACCESSION   XP_047288485
VERSION     XP_047288485.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432529.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..499
                     /product="myocyte-specific enhancer factor 2A isoform X5"
                     /calculated_mol_wt=53722
     Region          2..78
                     /region_name="MADS_MEF2_like"
                     /note="MEF2 (myocyte enhancer factor 2)-like/Type II
                     subfamily of MADS (MCM1, Agamous, Deficiens, and SRF
                     (serum response factor) box family of eukaryotic
                     transcriptional regulators. Binds DNA and exists as hetero
                     and homo-dimers. Differs from SRF-like/Type I...; cd00265"
                     /db_xref="CDD:238165"
     Site            order(2..4,6,8,13,15,19..20,23..24,26..27,30..31,33..34,
                     38)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238165"
     Site            order(21,28..29,32..33,35..36,39,44,46,48,54,56,62,65..66,
                     69,72..73)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:238165"
     Site            59
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:238165"
     Region          97..154
                     /region_name="HJURP_C"
                     /note="Holliday junction regulator protein family
                     C-terminal repeat; pfam12347"
                     /db_xref="CDD:463543"
     CDS             1..499
                     /gene="MEF2A"
                     /gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
                     /coded_by="XM_047432529.1:451..1950"
                     /db_xref="GeneID:4205"
                     /db_xref="HGNC:HGNC:6993"
                     /db_xref="MIM:600660"
ORIGIN      
        1 mgrkkiqitr imdernrqvt ftkrkfglmk kayelsvlcd ceialiifns snklfqyast
       61 dmdkvllkyt eynephesrt nsdivealnk kehrgcdspd pdtsyvltph teekykkine
      121 efdnmmrnhk iapglppqnf smsvtvpvts pnalsytnpg sslvspslaa sstltdssml
      181 sppqttlhrn vspgapqrpp stgnaggmls ttdltvpnga gsspvgngfv nsraspnlig
      241 atganslgkv mptksppppg ggnlgmnsrk pdlrvvipps skgmmpplnt qrisssqatq
      301 platpvvsvt tpslppqglv ysamptaynt dysltsadls alqgfnspgm lslgqvsawq
      361 qhhlgqaals slvaggqlsq gsnlsintnq nisiksepis pprdrmtpsg fqqqqqqqqq
      421 qqpppppqpq pqppqpqprq emgrspvdsl ssssssydgs dredprgdfh spivlgrppn
      481 tedrespsvk rmrmdawvt
//
LOCUS       XP_047288486             497 aa            linear   PRI 05-AUG-2025
DEFINITION  myocyte-specific enhancer factor 2A isoform X6 [Homo sapiens].
ACCESSION   XP_047288486
VERSION     XP_047288486.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432530.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..497
                     /product="myocyte-specific enhancer factor 2A isoform X6"
                     /calculated_mol_wt=53352
     Region          1..>235
                     /region_name="ARG80"
                     /note="Regulator of arginine metabolism and related MADS
                     box-containing transcription factors [Transcription];
                     COG5068"
                     /db_xref="CDD:227400"
     Region          2..78
                     /region_name="MADS_MEF2_like"
                     /note="MEF2 (myocyte enhancer factor 2)-like/Type II
                     subfamily of MADS (MCM1, Agamous, Deficiens, and SRF
                     (serum response factor) box family of eukaryotic
                     transcriptional regulators. Binds DNA and exists as hetero
                     and homo-dimers. Differs from SRF-like/Type I...; cd00265"
                     /db_xref="CDD:238165"
     Site            order(2..4,6,8,13,15,19..20,23..24,26..27,30..31,33..34,
                     38)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238165"
     Site            order(21,28..29,32..33,35..36,39,44,46,48,54,56,62,65..66,
                     69,72..73)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:238165"
     Site            59
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:238165"
     CDS             1..497
                     /gene="MEF2A"
                     /gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
                     /coded_by="XM_047432530.1:588..2081"
                     /db_xref="GeneID:4205"
                     /db_xref="HGNC:HGNC:6993"
                     /db_xref="MIM:600660"
ORIGIN      
        1 mgrkkiqitr imdernrqvt ftkrkfglmk kayelsvlcd ceialiifns snklfqyast
       61 dmdkvllkyt eynephesrt nsdivetlrk kglngcespd addyfehspl sedrfsklne
      121 dsdfifkrgp pglppqnfsm svtvpvtspn alsytnpgss lvspslaass tltdssmlsp
      181 pqttlhrnvs pgapqrppst gnaggmlstt dltvpngags spvgngfvns raspnligat
      241 ganslgkvmp tksppppggg nlgmnsrkpd lrvvippssk gmmpplntqr isssqatqpl
      301 atpvvsvttp slppqglvys amptayntdy sltsadlsal qgfnspgmls lgqvsawqqh
      361 hlgqaalssl vaggqlsqgs nlsintnqni siksepispp rdrmtpsgfq qqqqqqqqqq
      421 pppppqpqpq ppqpqprqem grspvdslss ssssydgsdr edprgdfhsp ivlgrppnte
      481 drespsvkrm rmdawvt
//
LOCUS       XP_047288487             497 aa            linear   PRI 05-AUG-2025
DEFINITION  myocyte-specific enhancer factor 2A isoform X6 [Homo sapiens].
ACCESSION   XP_047288487
VERSION     XP_047288487.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432531.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..497
                     /product="myocyte-specific enhancer factor 2A isoform X6"
                     /calculated_mol_wt=53352
     Region          1..>235
                     /region_name="ARG80"
                     /note="Regulator of arginine metabolism and related MADS
                     box-containing transcription factors [Transcription];
                     COG5068"
                     /db_xref="CDD:227400"
     Region          2..78
                     /region_name="MADS_MEF2_like"
                     /note="MEF2 (myocyte enhancer factor 2)-like/Type II
                     subfamily of MADS (MCM1, Agamous, Deficiens, and SRF
                     (serum response factor) box family of eukaryotic
                     transcriptional regulators. Binds DNA and exists as hetero
                     and homo-dimers. Differs from SRF-like/Type I...; cd00265"
                     /db_xref="CDD:238165"
     Site            order(2..4,6,8,13,15,19..20,23..24,26..27,30..31,33..34,
                     38)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238165"
     Site            order(21,28..29,32..33,35..36,39,44,46,48,54,56,62,65..66,
                     69,72..73)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:238165"
     Site            59
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:238165"
     CDS             1..497
                     /gene="MEF2A"
                     /gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
                     /coded_by="XM_047432531.1:439..1932"
                     /db_xref="GeneID:4205"
                     /db_xref="HGNC:HGNC:6993"
                     /db_xref="MIM:600660"
ORIGIN      
        1 mgrkkiqitr imdernrqvt ftkrkfglmk kayelsvlcd ceialiifns snklfqyast
       61 dmdkvllkyt eynephesrt nsdivetlrk kglngcespd addyfehspl sedrfsklne
      121 dsdfifkrgp pglppqnfsm svtvpvtspn alsytnpgss lvspslaass tltdssmlsp
      181 pqttlhrnvs pgapqrppst gnaggmlstt dltvpngags spvgngfvns raspnligat
      241 ganslgkvmp tksppppggg nlgmnsrkpd lrvvippssk gmmpplntqr isssqatqpl
      301 atpvvsvttp slppqglvys amptayntdy sltsadlsal qgfnspgmls lgqvsawqqh
      361 hlgqaalssl vaggqlsqgs nlsintnqni siksepispp rdrmtpsgfq qqqqqqqqqq
      421 pppppqpqpq ppqpqprqem grspvdslss ssssydgsdr edprgdfhsp ivlgrppnte
      481 drespsvkrm rmdawvt
//
LOCUS       XP_011519887             443 aa            linear   PRI 05-AUG-2025
DEFINITION  myocyte-specific enhancer factor 2A isoform X7 [Homo sapiens].
ACCESSION   XP_011519887
VERSION     XP_011519887.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521585.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..443
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..443
                     /product="myocyte-specific enhancer factor 2A isoform X7"
                     /calculated_mol_wt=47183
     Region          29..90
                     /region_name="HJURP_C"
                     /note="Holliday junction regulator protein family
                     C-terminal repeat; pfam12347"
                     /db_xref="CDD:463543"
     CDS             1..443
                     /gene="MEF2A"
                     /gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
                     /coded_by="XM_011521585.3:346..1677"
                     /db_xref="GeneID:4205"
                     /db_xref="HGNC:HGNC:6993"
                     /db_xref="MIM:600660"
ORIGIN      
        1 mgrkkiqitr imdernrqal nkkehrgcds pdpdtsyvlt phteekykki neefdnmmrn
       61 hkiavstkpg lppqnfsmsv tvpvtspnal sytnpgsslv spslaasstl tdssmlsppq
      121 ttlhrnvspg apqrppstgn aggmlsttdl tvpngagssp vgngfvnsra spnligatga
      181 nslgkvmptk sppppgggnl gmnsrkpdlr vvippsskgm mpplseeeel elntqrisss
      241 qatqplatpv vsvttpslpp qglvysampt ayntdyslts adlsalqgfn spgmlslgqv
      301 sawqqhhlgq aalsslvagg qlsqgsnlsi ntnqnisiks epispprdrm tpsgfqqqqq
      361 qqqqqqpppp pqpqpqppqp qprqemgrsp vdslssssss ydgsdredpr gdfhspivlg
      421 rppntedres psvkrmrmda wvt
//
LOCUS       XP_047288488             439 aa            linear   PRI 05-AUG-2025
DEFINITION  myocyte-specific enhancer factor 2A isoform X8 [Homo sapiens].
ACCESSION   XP_047288488
VERSION     XP_047288488.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432532.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..439
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..439
                     /product="myocyte-specific enhancer factor 2A isoform X8"
                     /calculated_mol_wt=46767
     Region          29..86
                     /region_name="HJURP_C"
                     /note="Holliday junction regulator protein family
                     C-terminal repeat; pfam12347"
                     /db_xref="CDD:463543"
     CDS             1..439
                     /gene="MEF2A"
                     /gene_synonym="ADCAD1; mef2; RSRFC4; RSRFC9"
                     /coded_by="XM_047432532.1:346..1665"
                     /db_xref="GeneID:4205"
                     /db_xref="HGNC:HGNC:6993"
                     /db_xref="MIM:600660"
ORIGIN      
        1 mgrkkiqitr imdernrqal nkkehrgcds pdpdtsyvlt phteekykki neefdnmmrn
       61 hkiapglppq nfsmsvtvpv tspnalsytn pgsslvspsl aasstltdss mlsppqttlh
      121 rnvspgapqr ppstgnaggm lsttdltvpn gagsspvgng fvnsraspnl igatganslg
      181 kvmptksppp pgggnlgmns rkpdlrvvip psskgmmppl seeeelelnt qrisssqatq
      241 platpvvsvt tpslppqglv ysamptaynt dysltsadls alqgfnspgm lslgqvsawq
      301 qhhlgqaals slvaggqlsq gsnlsintnq nisiksepis pprdrmtpsg fqqqqqqqqq
      361 qqpppppqpq pqppqpqprq emgrspvdsl ssssssydgs dredprgdfh spivlgrppn
      421 tedrespsvk rmrmdawvt
//
LOCUS       XP_047288489             387 aa            linear   PRI 05-AUG-2025
DEFINITION  lactadherin isoform X1 [Homo sapiens].
ACCESSION   XP_047288489
VERSION     XP_047288489.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432533.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..387
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..387
                     /product="lactadherin isoform X1"
                     /calculated_mol_wt=43179
     Region          28..67
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          72..224
                     /region_name="FA58C"
                     /note="Coagulation factor 5/8 C-terminal domain, discoidin
                     domain; Cell surface-attached carbohydrate-binding domain,
                     present in eukaryotes and assumed to have horizontally
                     transferred to eubacterial genomes; cd00057"
                     /db_xref="CDD:238014"
     Site            order(118,146,153)
                     /site_type="other"
                     /note="sugar binding site [chemical binding]"
                     /db_xref="CDD:238014"
     Region          232..386
                     /region_name="FA58C"
                     /note="Coagulation factor 5/8 C-terminal domain, discoidin
                     domain; Cell surface-attached carbohydrate-binding domain,
                     present in eukaryotes and assumed to have horizontally
                     transferred to eubacterial genomes; cd00057"
                     /db_xref="CDD:238014"
     Site            order(279,307,314)
                     /site_type="other"
                     /note="sugar binding site [chemical binding]"
                     /db_xref="CDD:238014"
     CDS             1..387
                     /gene="MFGE8"
                     /gene_synonym="BA46; EDIL1; HMFG; hP47; HsT19888; MFG-E8;
                     MFGM; OAcGD3S; SED1; SPAG10"
                     /coded_by="XM_047432533.1:722..1885"
                     /db_xref="GeneID:4240"
                     /db_xref="HGNC:HGNC:7036"
                     /db_xref="MIM:602281"
ORIGIN      
        1 mgltearvmw pfpeggntip ilhtdicskn pchngglcee isqevrgdvf psytctclkg
       61 yagnhcetkc veplglengn iansqiaass vrvtflglqh wvpelarlnr agmvnawtps
      121 snddnpwiqv nllrrmwvtg vvtqgasrla sheylkafkv ayslnghefd fihdvnkkhk
      181 efvgnwnkna vhvnlfetpv eaqyvrlypt schtactlrf ellgcelngc anplglknns
      241 ipdkqitass syktwglhlf swnpsyarld kqgnfnawva gsygndqwlq vdlgsskevt
      301 giitqgarnf gsvqfvasyk vaysndsanw teyqdprtgs skifpgnwdn hshkknlfet
      361 pilaryvril pvawhnrial rlellgc
//
LOCUS       XP_047288490             327 aa            linear   PRI 05-AUG-2025
DEFINITION  lactadherin isoform X2 [Homo sapiens].
ACCESSION   XP_047288490
VERSION     XP_047288490.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432534.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..327
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..327
                     /product="lactadherin isoform X2"
                     /calculated_mol_wt=36721
     Region          20..59
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          64..216
                     /region_name="FA58C"
                     /note="Coagulation factor 5/8 C-terminal domain, discoidin
                     domain; Cell surface-attached carbohydrate-binding domain,
                     present in eukaryotes and assumed to have horizontally
                     transferred to eubacterial genomes; cd00057"
                     /db_xref="CDD:238014"
     Site            order(110,138,145)
                     /site_type="other"
                     /note="sugar binding site [chemical binding]"
                     /db_xref="CDD:238014"
     Region          221..327
                     /region_name="FA58C"
                     /note="Coagulation factor 5/8 C-terminal domain, discoidin
                     domain; smart00231"
                     /db_xref="CDD:214572"
     CDS             1..327
                     /gene="MFGE8"
                     /gene_synonym="BA46; EDIL1; HMFG; hP47; HsT19888; MFG-E8;
                     MFGM; OAcGD3S; SED1; SPAG10"
                     /coded_by="XM_047432534.1:5..988"
                     /db_xref="GeneID:4240"
                     /db_xref="HGNC:HGNC:7036"
                     /db_xref="MIM:602281"
ORIGIN      
        1 mwpfpeggnt ipilhtdics knpchngglc eeisqevrgd vfpsytctcl kgyagnhcet
       61 kcveplglen gniansqiaa ssvrvtflgl qhwvpelarl nragmvnawt pssnddnpwi
      121 qvnllrrmwv tgvvtqgasr lasheylkaf kvayslnghe fdfihdvnkk hkefvgnwnk
      181 navhvnlfet pveaqyvrly ptschtactl rfellgceln gcanplglkn nsipdkqita
      241 sssyktwglh lfswnpsyar ldkqgnfnaw vagsygndqw lqifpgnwdn hshkknlfet
      301 pilaryvril pvawhnrial rlellgc
//
LOCUS       XP_016877695             243 aa            linear   PRI 05-AUG-2025
DEFINITION  lactadherin isoform X3 [Homo sapiens].
ACCESSION   XP_016877695
VERSION     XP_016877695.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022206.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..243
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..243
                     /product="lactadherin isoform X3"
                     /calculated_mol_wt=26908
     Region          28..67
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          72..224
                     /region_name="FA58C"
                     /note="Coagulation factor 5/8 C-terminal domain, discoidin
                     domain; Cell surface-attached carbohydrate-binding domain,
                     present in eukaryotes and assumed to have horizontally
                     transferred to eubacterial genomes; cd00057"
                     /db_xref="CDD:238014"
     Site            order(118,146,153)
                     /site_type="other"
                     /note="sugar binding site [chemical binding]"
                     /db_xref="CDD:238014"
     CDS             1..243
                     /gene="MFGE8"
                     /gene_synonym="BA46; EDIL1; HMFG; hP47; HsT19888; MFG-E8;
                     MFGM; OAcGD3S; SED1; SPAG10"
                     /coded_by="XM_017022206.3:61..792"
                     /db_xref="GeneID:4240"
                     /db_xref="HGNC:HGNC:7036"
                     /db_xref="MIM:602281"
ORIGIN      
        1 mprprllaal cgallcapsl lvaldicskn pchngglcee isqevrgdvf psytctclkg
       61 yagnhcetkc veplglengn iansqiaass vrvtflglqh wvpelarlnr agmvnawtps
      121 snddnpwiqv nllrrmwvtg vvtqgasrla sheylkafkv ayslnghefd fihdvnkkhk
      181 efvgnwnkna vhvnlfetpv eaqyvrlypt schtactlrf ellgcelnar kadlrrgadd
      241 req
//
LOCUS       XP_047288491             235 aa            linear   PRI 05-AUG-2025
DEFINITION  lactadherin isoform X4 [Homo sapiens].
ACCESSION   XP_047288491
VERSION     XP_047288491.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432535.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..235
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..235
                     /product="lactadherin isoform X4"
                     /calculated_mol_wt=26255
     Region          20..59
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          64..216
                     /region_name="FA58C"
                     /note="Coagulation factor 5/8 C-terminal domain, discoidin
                     domain; Cell surface-attached carbohydrate-binding domain,
                     present in eukaryotes and assumed to have horizontally
                     transferred to eubacterial genomes; cd00057"
                     /db_xref="CDD:238014"
     Site            order(110,138,145)
                     /site_type="other"
                     /note="sugar binding site [chemical binding]"
                     /db_xref="CDD:238014"
     CDS             1..235
                     /gene="MFGE8"
                     /gene_synonym="BA46; EDIL1; HMFG; hP47; HsT19888; MFG-E8;
                     MFGM; OAcGD3S; SED1; SPAG10"
                     /coded_by="XM_047432535.1:5..712"
                     /db_xref="GeneID:4240"
                     /db_xref="HGNC:HGNC:7036"
                     /db_xref="MIM:602281"
ORIGIN      
        1 mwpfpeggnt ipilhtdics knpchngglc eeisqevrgd vfpsytctcl kgyagnhcet
       61 kcveplglen gniansqiaa ssvrvtflgl qhwvpelarl nragmvnawt pssnddnpwi
      121 qvnllrrmwv tgvvtqgasr lasheylkaf kvayslnghe fdfihdvnkk hkefvgnwnk
      181 navhvnlfet pveaqyvrly ptschtactl rfellgceln arkadlrrga ddreq
//
LOCUS       XP_047288492             419 aa            linear   PRI 05-AUG-2025
DEFINITION  mannose-6-phosphate isomerase isoform X1 [Homo sapiens].
ACCESSION   XP_047288492
VERSION     XP_047288492.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432536.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..419
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..419
                     /product="mannose-6-phosphate isomerase isoform X1"
                     /calculated_mol_wt=46130
     Region          5..402
                     /region_name="cupin_RmlC-like"
                     /note="RmlC-like cupin superfamily; cl40423"
                     /db_xref="CDD:477354"
     Site            order(14,44,46,95,103..104,106,108,131,133,135,272,274,
                     281,283,287,291)
                     /site_type="active"
                     /db_xref="CDD:380414"
     CDS             1..419
                     /gene="MPI"
                     /gene_synonym="CDG1B; PMI; PMI1"
                     /coded_by="XM_047432536.1:157..1416"
                     /db_xref="GeneID:4351"
                     /db_xref="HGNC:HGNC:7216"
                     /db_xref="MIM:154550"
ORIGIN      
        1 mvfplscavq qyawgkmgsn sevarllass dplaqiaedk pyaelwmgth prgdakildn
       61 risqktlsqw iaenqdslgs kvkdtfngnl pflfkvlsve tplsiqahpn kelaeklhlq
      121 apqhypdanh kpemaialtp fqglcgfrpv eeivtflkkv pefqfligde aathlkqtms
      181 hdsqavassl qscfshlmks ekkvvveqln llvkrisqqa aagnnmedif gelllqlhqq
      241 ypgdigcfai yflnlltlkp geamfleanv phaylkgdcv ecmacsdntv ragltpkfid
      301 vptlcemlsy tpssskdrlf lptrsqedpy lsiydppvpd ftimktevpg svteykvlal
      361 dsasillmvq gtviastptt qtpiplqrgg vlfiganesv slkltepkdl lifraccll
//
LOCUS       XP_047288493             283 aa            linear   PRI 05-AUG-2025
DEFINITION  mannose-6-phosphate isomerase isoform X2 [Homo sapiens].
ACCESSION   XP_047288493
VERSION     XP_047288493.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432537.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..283
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..283
                     /product="mannose-6-phosphate isomerase isoform X2"
                     /calculated_mol_wt=31378
     Region          5..>277
                     /region_name="cupin_RmlC-like"
                     /note="RmlC-like cupin superfamily; cl40423"
                     /db_xref="CDD:477354"
     CDS             1..283
                     /gene="MPI"
                     /gene_synonym="CDG1B; PMI; PMI1"
                     /coded_by="XM_047432537.1:157..1008"
                     /db_xref="GeneID:4351"
                     /db_xref="HGNC:HGNC:7216"
                     /db_xref="MIM:154550"
ORIGIN      
        1 mvfplscavq qyawgkmgsn sevarllass dplaqiaedk pyaelwmgth prgdakildn
       61 risqktlsqw iaenqdslgs kvkdtfngnl pflfkvlsve tplsiqahpn kelaeklhlq
      121 apqhypdanh kpemaialtp fqglcgfrpv eeivtflkkv pefqfligde aathlkqtms
      181 hdsqavassl qscfshlmks ekkvvveqln llvkrisqqa aagnnmedif gelllqlhqq
      241 ypgdigcfai yflnlltlkp geamfleanv phaylkggpw lch
//
LOCUS       XP_047288494            2214 aa            linear   PRI 05-AUG-2025
DEFINITION  protein unc-13 homolog C isoform X1 [Homo sapiens].
ACCESSION   XP_047288494
VERSION     XP_047288494.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432538.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 24% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2214
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2214
                     /product="protein unc-13 homolog C isoform X1"
                     /calculated_mol_wt=250782
     Region          1079..1160
                     /region_name="C1_Munc13-2-like"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in Munc13-2, Munc13-3 and similar proteins; cd20859"
                     /db_xref="CDD:410409"
     Site            order(1103..1109,1117..1121,1124)
                     /site_type="other"
                     /note="putative DAG/PE binding site [chemical binding]"
                     /db_xref="CDD:410409"
     Region          1220..1346
                     /region_name="C2B_Munc13"
                     /note="C2 domain second repeat in Munc13 (mammalian
                     uncoordinated) proteins; cd04027"
                     /db_xref="CDD:175993"
     Site            order(1236,1242,1288,1290,1307)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:175993"
     Region          1540..2028
                     /region_name="MUN"
                     /note="MUN domain; pfam06292"
                     /db_xref="CDD:461870"
     Region          2062..2181
                     /region_name="C2C_Munc13"
                     /note="C2 domain third repeat in Munc13 (mammalian
                     uncoordinated) proteins; cd08395"
                     /db_xref="CDD:176041"
     CDS             1..2214
                     /gene="UNC13C"
                     /coded_by="XM_047432538.1:5194..11838"
                     /db_xref="GeneID:440279"
                     /db_xref="HGNC:HGNC:23149"
                     /db_xref="MIM:614568"
ORIGIN      
        1 mvanffksli lpyihklckg mftkklgntn knkeyrqqkk dqdfptagqt kspkfsytfk
       61 stvkkiakcs sthnlsteed easkefslsp tfsyrvaian glqknakvtn sdnedllqel
      121 ssiessyses lnelrssten qaqsthtmpv rrnrkssssl apsegssdge rtlhglklga
      181 lrklrkwkks qecvssdsel stmkkswgir sksldrtvrn pktnalepgf sssgcisqth
      241 dvmemifkel qgisqietel selrghvnal khsideisss vevvqseieq lrtgfvqsrr
      301 etrdihdyik hlghmgskas lrflnvteer feyvesvvyq ilidkmgfsd apnaikiefa
      361 qrighqrdcp nakprpilvy fetpqqrdsv lkksyklkgt gigistdilt hdirerkekg
      421 ipssqtyesm aiklstpepk ikknnwqspd dsdedlesdl nrnsyavlsk selltkgsts
      481 kpsskshsar sknktanssr isnksdydki ssqlpesdil ekqttthyad atplwhsqsd
      541 fftaklsrse sdfsklcqsy sedfsenqff trtngsslls ssdrelwqrk qegtatlyds
      601 pkdqhlnggv qgiqgqtete ntetvdsgms ngmvcasgdr shysdsqlsl hedlspwkew
      661 nqgadlglds stqegfdyet nslfdqqldv ynkdleylgk chsdlqddse sydltqddns
      721 spcpgldnep qgqwvgqyds yqgansnely qnqnqlsmmy rsqselqsdd sedappkswh
      781 srlsidlsdk tfsfpkfgst lqraksalev vwnkstqsls gyedsgsslm grfrtlsqst
      841 anessttlds dvytepyyyk aedeedytep vadnetdyve vmeqvlakle nrtsitetde
      901 qmqaydhlsy etpyetpqde gydgpaddmv seegleplne tsaemeired enqnipeqpv
      961 eitkpkrirp sfkeaalray kkqmaeleek ilagdsssvd ekarivsgnd ldaskfsalq
     1021 vcggagggly gidsmpdlrr kktlpivrdv amtlaarksg lslamvirts lnneelkmhv
     1081 fkktlqaliy pmsstiphnf evwtattpty cyecegllwg iarqgmkcle cgvkchekcq
     1141 dllnadclqr aaeksskhga edktqtiita mkermkirek nrpevfeviq emfqiskedf
     1201 vqftkaakqs vldgtskwsa kititvvsaq glqakdktgs sdpyvtvqvg knkrrtktif
     1261 gnlnpvwdek fyfechnstd rikvrvwded ddiksrvkqh fkkesddflg qtivevrtls
     1321 gemdvwynle krtdksavsg airlkinvei kgeekvapyh iqytclhenl fhyltevksn
     1381 ggvkipevkg deawkvffdd asqeivdefa mrygiesiyq amthfsclss kymcpgvpav
     1441 mstllanina fyahttvstn iqvsasdrfa atnfgrekfi klldqlhnsl ridlskyren
     1501 fpasnterlq dlkstvdllt sitffrmkvl elqsppkasm vvkdcvracl dstykyifdn
     1561 chelysqltd pskkqdipre dqgpttknld fwpqlitlmv tiidedktay tpvlnqfpqe
     1621 lnmgkisaei mwtlfaldmk yaleehenqr lckstdymnl hfkvkwfyne yvrelpafkd
     1681 avpeyslwfe pfvmqwlden edvsmeflhg algrdkkdgf qqtsehalfs csvvdvfaql
     1741 nqsfeiikkl ecpnpealsh lmrrfaktin kvllqyaaiv ssdfsshcdk envpcilmnn
     1801 iqqlrvqlek mfesmggkel dseastilke lqvklsgvld elsvtygesf qviieecikq
     1861 msfelnqmra ngnttsnkns aamdaeivlr slmdfldktl slsakicekt vlkrvlkelw
     1921 klvlnkiekq ivlppltdqt gpqmifiaak dlgqlsklke hmiredargl tprqcaimev
     1981 vlatikqyfh aggnglkknf lekspdlqsl ryalslytqt tdalikkfid tqtsqsrssk
     2041 davgqisvhv ditatpgtgd hkvtvkviai ndlnwqttam frpfvevcil gpnlgdkkrk
     2101 qgtktksntw spkynetfqf ilgkenrpga yelhlsvkdy cfaredriig mtviqlqnia
     2161 ekgsygawyp llknismdet gltilrilsq rtsddvakef vrlksetrst eesa
//
LOCUS       XP_016877710            2214 aa            linear   PRI 05-AUG-2025
DEFINITION  protein unc-13 homolog C isoform X1 [Homo sapiens].
ACCESSION   XP_016877710
VERSION     XP_016877710.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022221.2
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 24% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2214
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2214
                     /product="protein unc-13 homolog C isoform X1"
                     /calculated_mol_wt=250782
     Region          1079..1160
                     /region_name="C1_Munc13-2-like"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in Munc13-2, Munc13-3 and similar proteins; cd20859"
                     /db_xref="CDD:410409"
     Site            order(1103..1109,1117..1121,1124)
                     /site_type="other"
                     /note="putative DAG/PE binding site [chemical binding]"
                     /db_xref="CDD:410409"
     Region          1220..1346
                     /region_name="C2B_Munc13"
                     /note="C2 domain second repeat in Munc13 (mammalian
                     uncoordinated) proteins; cd04027"
                     /db_xref="CDD:175993"
     Site            order(1236,1242,1288,1290,1307)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:175993"
     Region          1540..2028
                     /region_name="MUN"
                     /note="MUN domain; pfam06292"
                     /db_xref="CDD:461870"
     Region          2062..2181
                     /region_name="C2C_Munc13"
                     /note="C2 domain third repeat in Munc13 (mammalian
                     uncoordinated) proteins; cd08395"
                     /db_xref="CDD:176041"
     CDS             1..2214
                     /gene="UNC13C"
                     /coded_by="XM_017022221.2:723..7367"
                     /db_xref="GeneID:440279"
                     /db_xref="HGNC:HGNC:23149"
                     /db_xref="MIM:614568"
ORIGIN      
        1 mvanffksli lpyihklckg mftkklgntn knkeyrqqkk dqdfptagqt kspkfsytfk
       61 stvkkiakcs sthnlsteed easkefslsp tfsyrvaian glqknakvtn sdnedllqel
      121 ssiessyses lnelrssten qaqsthtmpv rrnrkssssl apsegssdge rtlhglklga
      181 lrklrkwkks qecvssdsel stmkkswgir sksldrtvrn pktnalepgf sssgcisqth
      241 dvmemifkel qgisqietel selrghvnal khsideisss vevvqseieq lrtgfvqsrr
      301 etrdihdyik hlghmgskas lrflnvteer feyvesvvyq ilidkmgfsd apnaikiefa
      361 qrighqrdcp nakprpilvy fetpqqrdsv lkksyklkgt gigistdilt hdirerkekg
      421 ipssqtyesm aiklstpepk ikknnwqspd dsdedlesdl nrnsyavlsk selltkgsts
      481 kpsskshsar sknktanssr isnksdydki ssqlpesdil ekqttthyad atplwhsqsd
      541 fftaklsrse sdfsklcqsy sedfsenqff trtngsslls ssdrelwqrk qegtatlyds
      601 pkdqhlnggv qgiqgqtete ntetvdsgms ngmvcasgdr shysdsqlsl hedlspwkew
      661 nqgadlglds stqegfdyet nslfdqqldv ynkdleylgk chsdlqddse sydltqddns
      721 spcpgldnep qgqwvgqyds yqgansnely qnqnqlsmmy rsqselqsdd sedappkswh
      781 srlsidlsdk tfsfpkfgst lqraksalev vwnkstqsls gyedsgsslm grfrtlsqst
      841 anessttlds dvytepyyyk aedeedytep vadnetdyve vmeqvlakle nrtsitetde
      901 qmqaydhlsy etpyetpqde gydgpaddmv seegleplne tsaemeired enqnipeqpv
      961 eitkpkrirp sfkeaalray kkqmaeleek ilagdsssvd ekarivsgnd ldaskfsalq
     1021 vcggagggly gidsmpdlrr kktlpivrdv amtlaarksg lslamvirts lnneelkmhv
     1081 fkktlqaliy pmsstiphnf evwtattpty cyecegllwg iarqgmkcle cgvkchekcq
     1141 dllnadclqr aaeksskhga edktqtiita mkermkirek nrpevfeviq emfqiskedf
     1201 vqftkaakqs vldgtskwsa kititvvsaq glqakdktgs sdpyvtvqvg knkrrtktif
     1261 gnlnpvwdek fyfechnstd rikvrvwded ddiksrvkqh fkkesddflg qtivevrtls
     1321 gemdvwynle krtdksavsg airlkinvei kgeekvapyh iqytclhenl fhyltevksn
     1381 ggvkipevkg deawkvffdd asqeivdefa mrygiesiyq amthfsclss kymcpgvpav
     1441 mstllanina fyahttvstn iqvsasdrfa atnfgrekfi klldqlhnsl ridlskyren
     1501 fpasnterlq dlkstvdllt sitffrmkvl elqsppkasm vvkdcvracl dstykyifdn
     1561 chelysqltd pskkqdipre dqgpttknld fwpqlitlmv tiidedktay tpvlnqfpqe
     1621 lnmgkisaei mwtlfaldmk yaleehenqr lckstdymnl hfkvkwfyne yvrelpafkd
     1681 avpeyslwfe pfvmqwlden edvsmeflhg algrdkkdgf qqtsehalfs csvvdvfaql
     1741 nqsfeiikkl ecpnpealsh lmrrfaktin kvllqyaaiv ssdfsshcdk envpcilmnn
     1801 iqqlrvqlek mfesmggkel dseastilke lqvklsgvld elsvtygesf qviieecikq
     1861 msfelnqmra ngnttsnkns aamdaeivlr slmdfldktl slsakicekt vlkrvlkelw
     1921 klvlnkiekq ivlppltdqt gpqmifiaak dlgqlsklke hmiredargl tprqcaimev
     1981 vlatikqyfh aggnglkknf lekspdlqsl ryalslytqt tdalikkfid tqtsqsrssk
     2041 davgqisvhv ditatpgtgd hkvtvkviai ndlnwqttam frpfvevcil gpnlgdkkrk
     2101 qgtktksntw spkynetfqf ilgkenrpga yelhlsvkdy cfaredriig mtviqlqnia
     2161 ekgsygawyp llknismdet gltilrilsq rtsddvakef vrlksetrst eesa
//
LOCUS       XP_016877709            2214 aa            linear   PRI 05-AUG-2025
DEFINITION  protein unc-13 homolog C isoform X1 [Homo sapiens].
ACCESSION   XP_016877709
VERSION     XP_016877709.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022220.2
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 24% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2214
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2214
                     /product="protein unc-13 homolog C isoform X1"
                     /calculated_mol_wt=250782
     Region          1079..1160
                     /region_name="C1_Munc13-2-like"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in Munc13-2, Munc13-3 and similar proteins; cd20859"
                     /db_xref="CDD:410409"
     Site            order(1103..1109,1117..1121,1124)
                     /site_type="other"
                     /note="putative DAG/PE binding site [chemical binding]"
                     /db_xref="CDD:410409"
     Region          1220..1346
                     /region_name="C2B_Munc13"
                     /note="C2 domain second repeat in Munc13 (mammalian
                     uncoordinated) proteins; cd04027"
                     /db_xref="CDD:175993"
     Site            order(1236,1242,1288,1290,1307)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:175993"
     Region          1540..2028
                     /region_name="MUN"
                     /note="MUN domain; pfam06292"
                     /db_xref="CDD:461870"
     Region          2062..2181
                     /region_name="C2C_Munc13"
                     /note="C2 domain third repeat in Munc13 (mammalian
                     uncoordinated) proteins; cd08395"
                     /db_xref="CDD:176041"
     CDS             1..2214
                     /gene="UNC13C"
                     /coded_by="XM_017022220.2:843..7487"
                     /db_xref="GeneID:440279"
                     /db_xref="HGNC:HGNC:23149"
                     /db_xref="MIM:614568"
ORIGIN      
        1 mvanffksli lpyihklckg mftkklgntn knkeyrqqkk dqdfptagqt kspkfsytfk
       61 stvkkiakcs sthnlsteed easkefslsp tfsyrvaian glqknakvtn sdnedllqel
      121 ssiessyses lnelrssten qaqsthtmpv rrnrkssssl apsegssdge rtlhglklga
      181 lrklrkwkks qecvssdsel stmkkswgir sksldrtvrn pktnalepgf sssgcisqth
      241 dvmemifkel qgisqietel selrghvnal khsideisss vevvqseieq lrtgfvqsrr
      301 etrdihdyik hlghmgskas lrflnvteer feyvesvvyq ilidkmgfsd apnaikiefa
      361 qrighqrdcp nakprpilvy fetpqqrdsv lkksyklkgt gigistdilt hdirerkekg
      421 ipssqtyesm aiklstpepk ikknnwqspd dsdedlesdl nrnsyavlsk selltkgsts
      481 kpsskshsar sknktanssr isnksdydki ssqlpesdil ekqttthyad atplwhsqsd
      541 fftaklsrse sdfsklcqsy sedfsenqff trtngsslls ssdrelwqrk qegtatlyds
      601 pkdqhlnggv qgiqgqtete ntetvdsgms ngmvcasgdr shysdsqlsl hedlspwkew
      661 nqgadlglds stqegfdyet nslfdqqldv ynkdleylgk chsdlqddse sydltqddns
      721 spcpgldnep qgqwvgqyds yqgansnely qnqnqlsmmy rsqselqsdd sedappkswh
      781 srlsidlsdk tfsfpkfgst lqraksalev vwnkstqsls gyedsgsslm grfrtlsqst
      841 anessttlds dvytepyyyk aedeedytep vadnetdyve vmeqvlakle nrtsitetde
      901 qmqaydhlsy etpyetpqde gydgpaddmv seegleplne tsaemeired enqnipeqpv
      961 eitkpkrirp sfkeaalray kkqmaeleek ilagdsssvd ekarivsgnd ldaskfsalq
     1021 vcggagggly gidsmpdlrr kktlpivrdv amtlaarksg lslamvirts lnneelkmhv
     1081 fkktlqaliy pmsstiphnf evwtattpty cyecegllwg iarqgmkcle cgvkchekcq
     1141 dllnadclqr aaeksskhga edktqtiita mkermkirek nrpevfeviq emfqiskedf
     1201 vqftkaakqs vldgtskwsa kititvvsaq glqakdktgs sdpyvtvqvg knkrrtktif
     1261 gnlnpvwdek fyfechnstd rikvrvwded ddiksrvkqh fkkesddflg qtivevrtls
     1321 gemdvwynle krtdksavsg airlkinvei kgeekvapyh iqytclhenl fhyltevksn
     1381 ggvkipevkg deawkvffdd asqeivdefa mrygiesiyq amthfsclss kymcpgvpav
     1441 mstllanina fyahttvstn iqvsasdrfa atnfgrekfi klldqlhnsl ridlskyren
     1501 fpasnterlq dlkstvdllt sitffrmkvl elqsppkasm vvkdcvracl dstykyifdn
     1561 chelysqltd pskkqdipre dqgpttknld fwpqlitlmv tiidedktay tpvlnqfpqe
     1621 lnmgkisaei mwtlfaldmk yaleehenqr lckstdymnl hfkvkwfyne yvrelpafkd
     1681 avpeyslwfe pfvmqwlden edvsmeflhg algrdkkdgf qqtsehalfs csvvdvfaql
     1741 nqsfeiikkl ecpnpealsh lmrrfaktin kvllqyaaiv ssdfsshcdk envpcilmnn
     1801 iqqlrvqlek mfesmggkel dseastilke lqvklsgvld elsvtygesf qviieecikq
     1861 msfelnqmra ngnttsnkns aamdaeivlr slmdfldktl slsakicekt vlkrvlkelw
     1921 klvlnkiekq ivlppltdqt gpqmifiaak dlgqlsklke hmiredargl tprqcaimev
     1981 vlatikqyfh aggnglkknf lekspdlqsl ryalslytqt tdalikkfid tqtsqsrssk
     2041 davgqisvhv ditatpgtgd hkvtvkviai ndlnwqttam frpfvevcil gpnlgdkkrk
     2101 qgtktksntw spkynetfqf ilgkenrpga yelhlsvkdy cfaredriig mtviqlqnia
     2161 ekgsygawyp llknismdet gltilrilsq rtsddvakef vrlksetrst eesa
//
LOCUS       XP_016877711            2214 aa            linear   PRI 05-AUG-2025
DEFINITION  protein unc-13 homolog C isoform X1 [Homo sapiens].
ACCESSION   XP_016877711
VERSION     XP_016877711.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022222.2
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 24% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2214
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2214
                     /product="protein unc-13 homolog C isoform X1"
                     /calculated_mol_wt=250782
     Region          1079..1160
                     /region_name="C1_Munc13-2-like"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in Munc13-2, Munc13-3 and similar proteins; cd20859"
                     /db_xref="CDD:410409"
     Site            order(1103..1109,1117..1121,1124)
                     /site_type="other"
                     /note="putative DAG/PE binding site [chemical binding]"
                     /db_xref="CDD:410409"
     Region          1220..1346
                     /region_name="C2B_Munc13"
                     /note="C2 domain second repeat in Munc13 (mammalian
                     uncoordinated) proteins; cd04027"
                     /db_xref="CDD:175993"
     Site            order(1236,1242,1288,1290,1307)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:175993"
     Region          1540..2028
                     /region_name="MUN"
                     /note="MUN domain; pfam06292"
                     /db_xref="CDD:461870"
     Region          2062..2181
                     /region_name="C2C_Munc13"
                     /note="C2 domain third repeat in Munc13 (mammalian
                     uncoordinated) proteins; cd08395"
                     /db_xref="CDD:176041"
     CDS             1..2214
                     /gene="UNC13C"
                     /coded_by="XM_017022222.2:621..7265"
                     /db_xref="GeneID:440279"
                     /db_xref="HGNC:HGNC:23149"
                     /db_xref="MIM:614568"
ORIGIN      
        1 mvanffksli lpyihklckg mftkklgntn knkeyrqqkk dqdfptagqt kspkfsytfk
       61 stvkkiakcs sthnlsteed easkefslsp tfsyrvaian glqknakvtn sdnedllqel
      121 ssiessyses lnelrssten qaqsthtmpv rrnrkssssl apsegssdge rtlhglklga
      181 lrklrkwkks qecvssdsel stmkkswgir sksldrtvrn pktnalepgf sssgcisqth
      241 dvmemifkel qgisqietel selrghvnal khsideisss vevvqseieq lrtgfvqsrr
      301 etrdihdyik hlghmgskas lrflnvteer feyvesvvyq ilidkmgfsd apnaikiefa
      361 qrighqrdcp nakprpilvy fetpqqrdsv lkksyklkgt gigistdilt hdirerkekg
      421 ipssqtyesm aiklstpepk ikknnwqspd dsdedlesdl nrnsyavlsk selltkgsts
      481 kpsskshsar sknktanssr isnksdydki ssqlpesdil ekqttthyad atplwhsqsd
      541 fftaklsrse sdfsklcqsy sedfsenqff trtngsslls ssdrelwqrk qegtatlyds
      601 pkdqhlnggv qgiqgqtete ntetvdsgms ngmvcasgdr shysdsqlsl hedlspwkew
      661 nqgadlglds stqegfdyet nslfdqqldv ynkdleylgk chsdlqddse sydltqddns
      721 spcpgldnep qgqwvgqyds yqgansnely qnqnqlsmmy rsqselqsdd sedappkswh
      781 srlsidlsdk tfsfpkfgst lqraksalev vwnkstqsls gyedsgsslm grfrtlsqst
      841 anessttlds dvytepyyyk aedeedytep vadnetdyve vmeqvlakle nrtsitetde
      901 qmqaydhlsy etpyetpqde gydgpaddmv seegleplne tsaemeired enqnipeqpv
      961 eitkpkrirp sfkeaalray kkqmaeleek ilagdsssvd ekarivsgnd ldaskfsalq
     1021 vcggagggly gidsmpdlrr kktlpivrdv amtlaarksg lslamvirts lnneelkmhv
     1081 fkktlqaliy pmsstiphnf evwtattpty cyecegllwg iarqgmkcle cgvkchekcq
     1141 dllnadclqr aaeksskhga edktqtiita mkermkirek nrpevfeviq emfqiskedf
     1201 vqftkaakqs vldgtskwsa kititvvsaq glqakdktgs sdpyvtvqvg knkrrtktif
     1261 gnlnpvwdek fyfechnstd rikvrvwded ddiksrvkqh fkkesddflg qtivevrtls
     1321 gemdvwynle krtdksavsg airlkinvei kgeekvapyh iqytclhenl fhyltevksn
     1381 ggvkipevkg deawkvffdd asqeivdefa mrygiesiyq amthfsclss kymcpgvpav
     1441 mstllanina fyahttvstn iqvsasdrfa atnfgrekfi klldqlhnsl ridlskyren
     1501 fpasnterlq dlkstvdllt sitffrmkvl elqsppkasm vvkdcvracl dstykyifdn
     1561 chelysqltd pskkqdipre dqgpttknld fwpqlitlmv tiidedktay tpvlnqfpqe
     1621 lnmgkisaei mwtlfaldmk yaleehenqr lckstdymnl hfkvkwfyne yvrelpafkd
     1681 avpeyslwfe pfvmqwlden edvsmeflhg algrdkkdgf qqtsehalfs csvvdvfaql
     1741 nqsfeiikkl ecpnpealsh lmrrfaktin kvllqyaaiv ssdfsshcdk envpcilmnn
     1801 iqqlrvqlek mfesmggkel dseastilke lqvklsgvld elsvtygesf qviieecikq
     1861 msfelnqmra ngnttsnkns aamdaeivlr slmdfldktl slsakicekt vlkrvlkelw
     1921 klvlnkiekq ivlppltdqt gpqmifiaak dlgqlsklke hmiredargl tprqcaimev
     1981 vlatikqyfh aggnglkknf lekspdlqsl ryalslytqt tdalikkfid tqtsqsrssk
     2041 davgqisvhv ditatpgtgd hkvtvkviai ndlnwqttam frpfvevcil gpnlgdkkrk
     2101 qgtktksntw spkynetfqf ilgkenrpga yelhlsvkdy cfaredriig mtviqlqnia
     2161 ekgsygawyp llknismdet gltilrilsq rtsddvakef vrlksetrst eesa
//
LOCUS       XP_016877714            1180 aa            linear   PRI 05-AUG-2025
DEFINITION  protein unc-13 homolog C isoform X2 [Homo sapiens].
ACCESSION   XP_016877714
VERSION     XP_016877714.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022225.2
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 45% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1180
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1180
                     /product="protein unc-13 homolog C isoform X2"
                     /calculated_mol_wt=134600
     Region          45..126
                     /region_name="C1_Munc13-2-like"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in Munc13-2, Munc13-3 and similar proteins; cd20859"
                     /db_xref="CDD:410409"
     Site            order(69..75,83..87,90)
                     /site_type="other"
                     /note="putative DAG/PE binding site [chemical binding]"
                     /db_xref="CDD:410409"
     Region          186..312
                     /region_name="C2B_Munc13"
                     /note="C2 domain second repeat in Munc13 (mammalian
                     uncoordinated) proteins; cd04027"
                     /db_xref="CDD:175993"
     Site            order(202,208,254,256,273)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:175993"
     Region          506..994
                     /region_name="MUN"
                     /note="MUN domain; pfam06292"
                     /db_xref="CDD:461870"
     Region          1028..1147
                     /region_name="C2C_Munc13"
                     /note="C2 domain third repeat in Munc13 (mammalian
                     uncoordinated) proteins; cd08395"
                     /db_xref="CDD:176041"
     CDS             1..1180
                     /gene="UNC13C"
                     /coded_by="XM_017022225.2:51..3593"
                     /db_xref="GeneID:440279"
                     /db_xref="HGNC:HGNC:23149"
                     /db_xref="MIM:614568"
ORIGIN      
        1 mpdlrrkktl pivrdvamtl aarksglsla mvirtslnne elkmhvfkkt lqaliypmss
       61 tiphnfevwt attptycyec egllwgiarq gmkclecgvk chekcqdlln adclqraaek
      121 sskhgaedkt qtiitamker mkireknrpe vfeviqemfq iskedfvqft kaakqsvldg
      181 tskwsakiti tvvsaqglqa kdktgssdpy vtvqvgknkr rtktifgnln pvwdekfyfe
      241 chnstdrikv rvwdedddik srvkqhfkke sddflgqtiv evrtlsgemd vwynlekrtd
      301 ksavsgairl kinveikgee kvapyhiqyt clhenlfhyl tevksnggvk ipevkgdeaw
      361 kvffddasqe ivdefamryg iesiyqamth fsclsskymc pgvpavmstl laninafyah
      421 ttvstniqvs asdrfaatnf grekfiklld qlhnslridl skyrenfpas nterlqdlks
      481 tvdlltsitf frmkvlelqs ppkasmvvkd cvracldsty kyifdnchel ysqltdpskk
      541 qdipredqgp ttknldfwpq litlmvtiid edktaytpvl nqfpqelnmg kisaeimwtl
      601 faldmkyale ehenqrlcks tdymnlhfkv kwfyneyvre lpafkdavpe yslwfepfvm
      661 qwldenedvs meflhgalgr dkkdgfqqts ehalfscsvv dvfaqlnqsf eiikklecpn
      721 pealshlmrr faktinkvll qyaaivssdf sshcdkenvp cilmnniqql rvqlekmfes
      781 mggkeldsea stilkelqvk lsgvldelsv tygesfqvii eecikqmsfe lnqmrangnt
      841 tsnknsaamd aeivlrslmd fldktlslsa kicektvlkr vlkelwklvl nkiekqivlp
      901 pltdqtgpqm ifiaakdlgq lsklkehmir edargltprq caimevvlat ikqyfhaggn
      961 glkknfleks pdlqslryal slytqttdal ikkfidtqts qsrsskdavg qisvhvdita
     1021 tpgtgdhkvt vkviaindln wqttamfrpf vevcilgpnl gdkkrkqgtk tksntwspky
     1081 netfqfilgk enrpgayelh lsvkdycfar edriigmtvi qlqniaekgs ygawypllkn
     1141 ismdetglti lrilsqrtsd dvakefvrlk setrsteesa
//
LOCUS       XP_011519903             412 aa            linear   PRI 05-AUG-2025
DEFINITION  golgin subfamily A member 6-like protein 9 isoform X1 [Homo
            sapiens].
ACCESSION   XP_011519903
VERSION     XP_011519903.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521601.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..412
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..412
                     /product="golgin subfamily A member 6-like protein 9
                     isoform X1"
                     /calculated_mol_wt=47024
     Region          75..>178
                     /region_name="GOLGA2L5"
                     /note="Putative golgin subfamily A member 2-like protein
                     5; pfam15070"
                     /db_xref="CDD:464485"
     CDS             1..412
                     /gene="GOLGA6L9"
                     /gene_synonym="GOLGA6L20"
                     /coded_by="XM_011521601.3:265..1503"
                     /db_xref="GeneID:440295"
                     /db_xref="HGNC:HGNC:37229"
ORIGIN      
        1 mwpqprlpph pamsektqqg klaaakkklk aywqrkspgi paganrkkki ngsspdtfts
       61 ggyhspgdsq yqelavalds ssaiisqlte ninslvrtsk eekkheihlv qklgrslfkl
      121 knqtaeplap qppagpskme qlqdetnhlr kelesvgrql qaevennqml sllnrrqeer
      181 lreqeerlre qeerlceqee rlceqeerlr eqeerlceqe klpgqerlle eveklleqer
      241 rqeeqerlle rerlldevee lleqerlrqq derlwqqetl relerlrele rmlelgweal
      301 yeqraeprsg feelnnenks tlqleqqvke leksggaeep rgsesaaaar pvagapvpqg
      361 awmcgqagwt pqehpglsge avgtgeaagg ageaachsfr aaenrelnit ii
//
LOCUS       XP_047288495             274 aa            linear   PRI 05-AUG-2025
DEFINITION  golgin subfamily A member 6-like protein 9 isoform X2 [Homo
            sapiens].
ACCESSION   XP_047288495
VERSION     XP_047288495.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432539.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..274
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..274
                     /product="golgin subfamily A member 6-like protein 9
                     isoform X2"
                     /calculated_mol_wt=31951
     CDS             1..274
                     /gene="GOLGA6L9"
                     /gene_synonym="GOLGA6L20"
                     /coded_by="XM_047432539.1:4262..5086"
                     /db_xref="GeneID:440295"
                     /db_xref="HGNC:HGNC:37229"
ORIGIN      
        1 meqlqdetnh lrkelesvgr qlqaevennq mlsllnrrqe erlreqeerl reqeerlceq
       61 eerlceqeer lreqeerlce qeklpgqerl leeveklleq errqeeqerl lererlldev
      121 eelleqerlr qqderlwqqe tlrelerlre lermlelgwe alyeqraepr sgfeelnnen
      181 kstlqleqqv keleksggae eprgsesaaa arpvagapvp qgawmcgqag wtpqehpgls
      241 geavgtgeaa ggageaachs fraaenreln itii
//
LOCUS       XP_016877715             222 aa            linear   PRI 05-AUG-2025
DEFINITION  golgin subfamily A member 6-like protein 9 isoform X3 [Homo
            sapiens].
ACCESSION   XP_016877715
VERSION     XP_016877715.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022226.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..222
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..222
                     /product="golgin subfamily A member 6-like protein 9
                     isoform X3"
                     /calculated_mol_wt=23291
     Region          <80..145
                     /region_name="Spc7"
                     /note="Spc7 kinetochore protein; smart00787"
                     /db_xref="CDD:197874"
     CDS             1..222
                     /gene="GOLGA6L9"
                     /gene_synonym="GOLGA6L20"
                     /coded_by="XM_017022226.2:265..933"
                     /db_xref="GeneID:440295"
                     /db_xref="HGNC:HGNC:37229"
ORIGIN      
        1 mwpqprlpph pamsektqqg klaaakkklk aywqrkspgi paganrkkki ngsspdtfts
       61 ggyhspgdsa tgiygegras sttlqdlesq yqelavalds ssaiisqlte ninslvrtsk
      121 eekkheihlv qklgrslfkl knqtggaeep rgsesaaaar pvagapvpqg awmcgqagwt
      181 pqehpglsge avgtgeaagg ageaachsfr aaenrelnit ii
//
LOCUS       XP_047288496            1877 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-Va isoform X1 [Homo sapiens].
ACCESSION   XP_047288496
VERSION     XP_047288496.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432540.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1877
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1877
                     /product="unconventional myosin-Va isoform X1"
                     /calculated_mol_wt=218119
     Region          7..1445
                     /region_name="COG5022"
                     /note="Myosin heavy chain [General function prediction
                     only]"
                     /db_xref="CDD:227355"
     Region          83..751
                     /region_name="MYSc_Myo5"
                     /note="class V myosin, motor domain; cd01380"
                     /db_xref="CDD:276831"
     Site            order(111..119,163..170,209..219,437..442)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276831"
     Site            111..119
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276831"
     Site            163..170
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276831"
     Site            209..219
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276831"
     Site            437..445
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276831"
     Site            order(466..477,480..489)
                     /site_type="active"
                     /note="relay loop [active]"
                     /db_xref="CDD:276831"
     Site            685..695
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276831"
     Site            order(706..716,736..751)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276831"
     Region          1503..1877
                     /region_name="Myo5a_CBD"
                     /note="Cargo binding domain of myosin 5a; cd15478"
                     /db_xref="CDD:271262"
     Site            order(1520..1522,1525..1528,1698..1699,1857,1862,1864,
                     1866..1868)
                     /site_type="other"
                     /note="RILPL2 interface [polypeptide binding]"
                     /db_xref="CDD:271262"
     Site            order(1548,1551..1552,1555..1556,1559..1560,1563,1594,
                     1612..1617,1619..1620,1623)
                     /site_type="other"
                     /note="melanophilin interface [polypeptide binding]"
                     /db_xref="CDD:271262"
     CDS             1..1877
                     /gene="MYO5A"
                     /gene_synonym="GS1; MYH12; MYO5; MYR12"
                     /coded_by="XM_047432540.1:245..5878"
                     /db_xref="GeneID:4644"
                     /db_xref="HGNC:HGNC:7602"
                     /db_xref="MIM:160777"
ORIGIN      
        1 maaselytkf arvwipdpee vwksaellkd ykpgdkvlll hleegkdley hldpktkelp
       61 hlrnpdilvg endltalsyl hepavlhnlr vrfidskliy tycgivlvai npyeqlpiyg
      121 ediinaysgq nmgdmdphif avaeeaykqm ardernqsii vsgesgagkt vsakyamryf
      181 atvsgsasea nveekvlasn pimesignak ttrndnssrf gkyieigfdk ryriiganmr
      241 tylleksrvv fqaeeernyh ifyqlcasak lpefkmlrlg nadnfnytkq ggspviegvd
      301 dakemahtrq actllgises hqmgifrila gilhlgnvgf tsrdadscti ppkheplcif
      361 celmgvdyee mchwlchrkl atatetyikp isklqatnar dalakhiyak lfnwivdnvn
      421 qalhsavkqh sfigvldiyg fetfeinsfe qfcinyanek lqqqfnmhvf kleqeeymke
      481 qipwtlidfy dnqpcinlie sklgildlld eeckmpkgtd dtwaqklynt hlnkcalfek
      541 prlsnkafii qhfadkveyq cegfleknkd tvfeeqikvl ksskfkmlpe lfqddekais
      601 ptsatssgrt pltrtpakpt kgrpgqmake hkktvghqfr nslhllmetl nattphyvrc
      661 ikpndfkfpf tfdekravqq lracgvleti risaagfpsr wtyqeffsry rvlmkqkdvl
      721 sdrkqtcknv leklildkdk yqfgktkiff ragqvaylek lradklraac iriqktirgw
      781 llrkkylrmr kaaitmqryv rgyqarcyak flrrtkaati iqkywrmyvv rrrykirraa
      841 tivlqsylrg flarnryrki lrehkaviiq krvrgwlart hykrsmhaii ylqccfrrmm
      901 akrelkklki earsverykk lhigmenkim qlqrkvdeqn kdykclvekl tnlegiynse
      961 teklrsdler lqlseeeakv atgrvlslqe eiaklrkdle qtrsekkcie ehadrykqet
     1021 eqlvsnlkee ntllkqekea lnhrivqqak emtetmekkl veetkqleld lnderlryqn
     1081 llnefsrlee ryddlkeemt lmvhvpkpgh krtdsthssn eseyifssei aemedipsrt
     1141 eepsekkvpl dmslflklqk rvteleqekq vmqdeldrke eqvlrskake eerpqirgae
     1201 leyeslkrqe lesenkklkn elnelrkals eksapevtap gapayrvlme qltsvseeld
     1261 vrkeevlilr sqlvsqkeai qpkntmtdst illedvqkmk dkgeiaqayi glketnrssa
     1321 ldyhelnedg elwlvyeglk qanrllesql qsqkrshene aealrgeiqs lkeennrqqq
     1381 llaqnlqlpp earieaslqh eitrltnenl yfeelyaddp kkyqsyrisl ykrmidlmeq
     1441 lekqdktvrk lkkqlkvfak kigelevgqm enispgqiid epirpvnipr kekdfqgmle
     1501 ykkedeqklv knlilelkpr gvavnlipgl payilfmcvr hadylnddqk vrslltstin
     1561 sikkvlkkrg ddfetvsfwl sntcrflhcl kqysgeegfm khntsrqneh cltnfdlaey
     1621 rqvlsdlaiq iyqqlvrvle nilqpmivsg mlehetiqgv sgvkptglrk rtssiadegt
     1681 ytldsilrql nsfhsvmcqh gmdpelikqv vkqmfyiiga itlnnlllrk dmcswskgmq
     1741 irynvsqlee wlrdknlmns gaketlepli qaaqllqvkk ktdddaeaic smcnalttaq
     1801 ivkvlnlytp vnefeervsv sfirtiqmrl rdrkdspqll mdakhifpvt fpfnpsslal
     1861 etiqipaslg lgfisrv
//
LOCUS       XP_047288497            1853 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-Va isoform X2 [Homo sapiens].
ACCESSION   XP_047288497
VERSION     XP_047288497.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432541.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1853
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1853
                     /product="unconventional myosin-Va isoform X2"
                     /calculated_mol_wt=215345
     Region          83..751
                     /region_name="MYSc_Myo5"
                     /note="class V myosin, motor domain; cd01380"
                     /db_xref="CDD:276831"
     Site            order(111..119,163..170,209..219,437..442)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276831"
     Site            111..119
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276831"
     Site            163..170
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276831"
     Site            209..219
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276831"
     Site            437..445
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276831"
     Site            order(466..477,480..489)
                     /site_type="active"
                     /note="relay loop [active]"
                     /db_xref="CDD:276831"
     Site            685..695
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276831"
     Site            order(706..716,736..751)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276831"
     Region          765..786
                     /region_name="IQ"
                     /note="Calmodulin-binding motif; smart00015"
                     /db_xref="CDD:197470"
     Region          788..810
                     /region_name="IQ"
                     /note="Calmodulin-binding motif; smart00015"
                     /db_xref="CDD:197470"
     Region          813..835
                     /region_name="IQ"
                     /note="Calmodulin-binding motif; smart00015"
                     /db_xref="CDD:197470"
     Region          <829..>862
                     /region_name="CBD_MYO6-like"
                     /note="calmodulin binding domain found in unconventional
                     myosin-VI and similar proteins; cd21759"
                     /db_xref="CDD:409646"
     Site            844..854
                     /site_type="other"
                     /note="IQ motif"
                     /db_xref="CDD:409646"
     Region          862..883
                     /region_name="IQ"
                     /note="Calmodulin-binding motif; smart00015"
                     /db_xref="CDD:197470"
     Region          902..>1281
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          1156..>1441
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          1479..1853
                     /region_name="Myo5a_CBD"
                     /note="Cargo binding domain of myosin 5a; cd15478"
                     /db_xref="CDD:271262"
     Site            order(1496..1498,1501..1504,1674..1675,1833,1838,1840,
                     1842..1844)
                     /site_type="other"
                     /note="RILPL2 interface [polypeptide binding]"
                     /db_xref="CDD:271262"
     Site            order(1524,1527..1528,1531..1532,1535..1536,1539,1570,
                     1588..1593,1595..1596,1599)
                     /site_type="other"
                     /note="melanophilin interface [polypeptide binding]"
                     /db_xref="CDD:271262"
     CDS             1..1853
                     /gene="MYO5A"
                     /gene_synonym="GS1; MYH12; MYO5; MYR12"
                     /coded_by="XM_047432541.1:245..5806"
                     /db_xref="GeneID:4644"
                     /db_xref="HGNC:HGNC:7602"
                     /db_xref="MIM:160777"
ORIGIN      
        1 maaselytkf arvwipdpee vwksaellkd ykpgdkvlll hleegkdley hldpktkelp
       61 hlrnpdilvg endltalsyl hepavlhnlr vrfidskliy tycgivlvai npyeqlpiyg
      121 ediinaysgq nmgdmdphif avaeeaykqm ardernqsii vsgesgagkt vsakyamryf
      181 atvsgsasea nveekvlasn pimesignak ttrndnssrf gkyieigfdk ryriiganmr
      241 tylleksrvv fqaeeernyh ifyqlcasak lpefkmlrlg nadnfnytkq ggspviegvd
      301 dakemahtrq actllgises hqmgifrila gilhlgnvgf tsrdadscti ppkheplcif
      361 celmgvdyee mchwlchrkl atatetyikp isklqatnar dalakhiyak lfnwivdnvn
      421 qalhsavkqh sfigvldiyg fetfeinsfe qfcinyanek lqqqfnmhvf kleqeeymke
      481 qipwtlidfy dnqpcinlie sklgildlld eeckmpkgtd dtwaqklynt hlnkcalfek
      541 prlsnkafii qhfadkveyq cegfleknkd tvfeeqikvl ksskfkmlpe lfqddekais
      601 ptsatssgrt pltrtpakpt kgrpgqmake hkktvghqfr nslhllmetl nattphyvrc
      661 ikpndfkfpf tfdekravqq lracgvleti risaagfpsr wtyqeffsry rvlmkqkdvl
      721 sdrkqtcknv leklildkdk yqfgktkiff ragqvaylek lradklraac iriqktirgw
      781 llrkkylrmr kaaitmqryv rgyqarcyak flrrtkaati iqkywrmyvv rrrykirraa
      841 tivlqsylrg flarnryrki lrehkaviiq krvrgwlart hykrsmhaii ylqccfrrmm
      901 akrelkklki earsverykk lhigmenkim qlqrkvdeqn kdykclvekl tnlegiynse
      961 teklrsdler lqlseeeakv atgrvlslqe eiaklrkdle qtrsekkcie ehadrykqet
     1021 eqlvsnlkee ntllkqekea lnhrivqqak emtetmekkl veetkqleld lnderlryqn
     1081 llnefsrlee ryddlkeemt lmvhvpkpgh krtdsthssn eseyifssei aemedipsrt
     1141 eepsekkvpl dmslflklqk rvteleqekq vmqdeldrke eqvlrskake eerpqirgae
     1201 leyeslkrqe lesenkklkn elnelrkals eksapevtap gapayrvlme qltsvseeld
     1261 vrkeevlilr sqlvsqkeai qpkddkntmt dstilledvq kmkdkgeiaq ayiglketnr
     1321 llesqlqsqk rsheneaeal rgeiqslkee nnrqqqllaq nlqlppeari easlqheitr
     1381 ltnenlyfee lyaddpkkyq syrislykrm idlmeqlekq dktvrklkkq lkvfakkige
     1441 levgqmenis pgqiidepir pvniprkekd fqgmleykke deqklvknli lelkprgvav
     1501 nlipglpayi lfmcvrhady lnddqkvrsl ltstinsikk vlkkrgddfe tvsfwlsntc
     1561 rflhclkqys geegfmkhnt srqnehcltn fdlaeyrqvl sdlaiqiyqq lvrvlenilq
     1621 pmivsgmleh etiqgvsgvk ptglrkrtss iadegtytld silrqlnsfh svmcqhgmdp
     1681 elikqvvkqm fyiigaitln nlllrkdmcs wskgmqiryn vsqleewlrd knlmnsgake
     1741 tlepliqaaq llqvkkktdd daeaicsmcn alttaqivkv lnlytpvnef eervsvsfir
     1801 tiqmrlrdrk dspqllmdak hifpvtfpfn psslaletiq ipaslglgfi srv
//
LOCUS       XP_047288499            1850 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-Va isoform X3 [Homo sapiens].
ACCESSION   XP_047288499
VERSION     XP_047288499.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432543.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1850
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1850
                     /product="unconventional myosin-Va isoform X3"
                     /calculated_mol_wt=214987
     Region          7..1291
                     /region_name="COG5022"
                     /note="Myosin heavy chain [General function prediction
                     only]"
                     /db_xref="CDD:227355"
     Region          83..751
                     /region_name="MYSc_Myo5"
                     /note="class V myosin, motor domain; cd01380"
                     /db_xref="CDD:276831"
     Site            order(111..119,163..170,209..219,437..442)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276831"
     Site            111..119
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276831"
     Site            163..170
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276831"
     Site            209..219
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276831"
     Site            437..445
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276831"
     Site            order(466..477,480..489)
                     /site_type="active"
                     /note="relay loop [active]"
                     /db_xref="CDD:276831"
     Site            685..695
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276831"
     Site            order(706..716,736..751)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276831"
     Region          1156..>1438
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          1476..1850
                     /region_name="Myo5a_CBD"
                     /note="Cargo binding domain of myosin 5a; cd15478"
                     /db_xref="CDD:271262"
     Site            order(1493..1495,1498..1501,1671..1672,1830,1835,1837,
                     1839..1841)
                     /site_type="other"
                     /note="RILPL2 interface [polypeptide binding]"
                     /db_xref="CDD:271262"
     Site            order(1521,1524..1525,1528..1529,1532..1533,1536,1567,
                     1585..1590,1592..1593,1596)
                     /site_type="other"
                     /note="melanophilin interface [polypeptide binding]"
                     /db_xref="CDD:271262"
     CDS             1..1850
                     /gene="MYO5A"
                     /gene_synonym="GS1; MYH12; MYO5; MYR12"
                     /coded_by="XM_047432543.1:245..5797"
                     /db_xref="GeneID:4644"
                     /db_xref="HGNC:HGNC:7602"
                     /db_xref="MIM:160777"
ORIGIN      
        1 maaselytkf arvwipdpee vwksaellkd ykpgdkvlll hleegkdley hldpktkelp
       61 hlrnpdilvg endltalsyl hepavlhnlr vrfidskliy tycgivlvai npyeqlpiyg
      121 ediinaysgq nmgdmdphif avaeeaykqm ardernqsii vsgesgagkt vsakyamryf
      181 atvsgsasea nveekvlasn pimesignak ttrndnssrf gkyieigfdk ryriiganmr
      241 tylleksrvv fqaeeernyh ifyqlcasak lpefkmlrlg nadnfnytkq ggspviegvd
      301 dakemahtrq actllgises hqmgifrila gilhlgnvgf tsrdadscti ppkheplcif
      361 celmgvdyee mchwlchrkl atatetyikp isklqatnar dalakhiyak lfnwivdnvn
      421 qalhsavkqh sfigvldiyg fetfeinsfe qfcinyanek lqqqfnmhvf kleqeeymke
      481 qipwtlidfy dnqpcinlie sklgildlld eeckmpkgtd dtwaqklynt hlnkcalfek
      541 prlsnkafii qhfadkveyq cegfleknkd tvfeeqikvl ksskfkmlpe lfqddekais
      601 ptsatssgrt pltrtpakpt kgrpgqmake hkktvghqfr nslhllmetl nattphyvrc
      661 ikpndfkfpf tfdekravqq lracgvleti risaagfpsr wtyqeffsry rvlmkqkdvl
      721 sdrkqtcknv leklildkdk yqfgktkiff ragqvaylek lradklraac iriqktirgw
      781 llrkkylrmr kaaitmqryv rgyqarcyak flrrtkaati iqkywrmyvv rrrykirraa
      841 tivlqsylrg flarnryrki lrehkaviiq krvrgwlart hykrsmhaii ylqccfrrmm
      901 akrelkklki earsverykk lhigmenkim qlqrkvdeqn kdykclvekl tnlegiynse
      961 teklrsdler lqlseeeakv atgrvlslqe eiaklrkdle qtrsekkcie ehadrykqet
     1021 eqlvsnlkee ntllkqekea lnhrivqqak emtetmekkl veetkqleld lnderlryqn
     1081 llnefsrlee ryddlkeemt lmvhvpkpgh krtdsthssn eseyifssei aemedipsrt
     1141 eepsekkvpl dmslflklqk rvteleqekq vmqdeldrke eqvlrskake eerpqirgae
     1201 leyeslkrqe lesenkklkn elnelrkals eksapevtap gapayrvlme qltsvseeld
     1261 vrkeevlilr sqlvsqkeai qpkntmtdst illedvqkmk dkgeiaqayi glketnrlle
     1321 sqlqsqkrsh eneaealrge iqslkeennr qqqllaqnlq lppearieas lqheitrltn
     1381 enlyfeelya ddpkkyqsyr islykrmidl meqlekqdkt vrklkkqlkv fakkigelev
     1441 gqmenispgq iidepirpvn iprkekdfqg mleykkedeq klvknlilel kprgvavnli
     1501 pglpayilfm cvrhadylnd dqkvrsllts tinsikkvlk krgddfetvs fwlsntcrfl
     1561 hclkqysgee gfmkhntsrq nehcltnfdl aeyrqvlsdl aiqiyqqlvr vlenilqpmi
     1621 vsgmleheti qgvsgvkptg lrkrtssiad egtytldsil rqlnsfhsvm cqhgmdpeli
     1681 kqvvkqmfyi igaitlnnll lrkdmcswsk gmqirynvsq leewlrdknl mnsgaketle
     1741 pliqaaqllq vkkktdddae aicsmcnalt taqivkvlnl ytpvnefeer vsvsfirtiq
     1801 mrlrdrkdsp qllmdakhif pvtfpfnpss laletiqipa slglgfisrv
//
LOCUS       XP_047288500            1825 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-Va isoform X4 [Homo sapiens].
ACCESSION   XP_047288500
VERSION     XP_047288500.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432544.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1825
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1825
                     /product="unconventional myosin-Va isoform X4"
                     /calculated_mol_wt=211784
     Region          7..1291
                     /region_name="COG5022"
                     /note="Myosin heavy chain [General function prediction
                     only]"
                     /db_xref="CDD:227355"
     Region          83..751
                     /region_name="MYSc_Myo5"
                     /note="class V myosin, motor domain; cd01380"
                     /db_xref="CDD:276831"
     Site            order(111..119,163..170,209..219,437..442)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276831"
     Site            111..119
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276831"
     Site            163..170
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276831"
     Site            209..219
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276831"
     Site            437..445
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276831"
     Site            order(466..477,480..489)
                     /site_type="active"
                     /note="relay loop [active]"
                     /db_xref="CDD:276831"
     Site            685..695
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276831"
     Site            order(706..716,736..751)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276831"
     Region          <1158..>1433
                     /region_name="GumC"
                     /note="Exopolysaccharide export protein/domain GumC/Wzc1
                     [Cell wall/membrane/envelope biogenesis]; COG3206"
                     /db_xref="CDD:442439"
     Region          1451..1825
                     /region_name="Myo5a_CBD"
                     /note="Cargo binding domain of myosin 5a; cd15478"
                     /db_xref="CDD:271262"
     Site            order(1468..1470,1473..1476,1646..1647,1805,1810,1812,
                     1814..1816)
                     /site_type="other"
                     /note="RILPL2 interface [polypeptide binding]"
                     /db_xref="CDD:271262"
     Site            order(1496,1499..1500,1503..1504,1507..1508,1511,1542,
                     1560..1565,1567..1568,1571)
                     /site_type="other"
                     /note="melanophilin interface [polypeptide binding]"
                     /db_xref="CDD:271262"
     CDS             1..1825
                     /gene="MYO5A"
                     /gene_synonym="GS1; MYH12; MYO5; MYR12"
                     /coded_by="XM_047432544.1:245..5722"
                     /db_xref="GeneID:4644"
                     /db_xref="HGNC:HGNC:7602"
                     /db_xref="MIM:160777"
ORIGIN      
        1 maaselytkf arvwipdpee vwksaellkd ykpgdkvlll hleegkdley hldpktkelp
       61 hlrnpdilvg endltalsyl hepavlhnlr vrfidskliy tycgivlvai npyeqlpiyg
      121 ediinaysgq nmgdmdphif avaeeaykqm ardernqsii vsgesgagkt vsakyamryf
      181 atvsgsasea nveekvlasn pimesignak ttrndnssrf gkyieigfdk ryriiganmr
      241 tylleksrvv fqaeeernyh ifyqlcasak lpefkmlrlg nadnfnytkq ggspviegvd
      301 dakemahtrq actllgises hqmgifrila gilhlgnvgf tsrdadscti ppkheplcif
      361 celmgvdyee mchwlchrkl atatetyikp isklqatnar dalakhiyak lfnwivdnvn
      421 qalhsavkqh sfigvldiyg fetfeinsfe qfcinyanek lqqqfnmhvf kleqeeymke
      481 qipwtlidfy dnqpcinlie sklgildlld eeckmpkgtd dtwaqklynt hlnkcalfek
      541 prlsnkafii qhfadkveyq cegfleknkd tvfeeqikvl ksskfkmlpe lfqddekais
      601 ptsatssgrt pltrtpakpt kgrpgqmake hkktvghqfr nslhllmetl nattphyvrc
      661 ikpndfkfpf tfdekravqq lracgvleti risaagfpsr wtyqeffsry rvlmkqkdvl
      721 sdrkqtcknv leklildkdk yqfgktkiff ragqvaylek lradklraac iriqktirgw
      781 llrkkylrmr kaaitmqryv rgyqarcyak flrrtkaati iqkywrmyvv rrrykirraa
      841 tivlqsylrg flarnryrki lrehkaviiq krvrgwlart hykrsmhaii ylqccfrrmm
      901 akrelkklki earsverykk lhigmenkim qlqrkvdeqn kdykclvekl tnlegiynse
      961 teklrsdler lqlseeeakv atgrvlslqe eiaklrkdle qtrsekkcie ehadrykqet
     1021 eqlvsnlkee ntllkqekea lnhrivqqak emtetmekkl veetkqleld lnderlryqn
     1081 llnefsrlee ryddlkeemt lmvhvpkpgh krtdsthssn eseyifssei aemedipsrt
     1141 eepsekkvpl dmslflklqk rvteleqekq vmqdeldrke eqvlrskake eerpqirgae
     1201 leyeslkrqe lesenkklkn elnelrkals eksapevtap gapayrvlme qltsvseeld
     1261 vrkeevlilr sqlvsqkeai qpkntmtdst illedvqkmk dkgeiaqayi glketnrlle
     1321 sqlqsqkrsh eneaealrge iqslkeennr qqqllaqnlq lppearieas lqheitrltn
     1381 enldlmeqle kqdktvrklk kqlkvfakki gelevgqmen ispgqiidep irpvniprke
     1441 kdfqgmleyk kedeqklvkn lilelkprgv avnlipglpa yilfmcvrha dylnddqkvr
     1501 slltstinsi kkvlkkrgdd fetvsfwlsn tcrflhclkq ysgeegfmkh ntsrqnehcl
     1561 tnfdlaeyrq vlsdlaiqiy qqlvrvleni lqpmivsgml ehetiqgvsg vkptglrkrt
     1621 ssiadegtyt ldsilrqlns fhsvmcqhgm dpelikqvvk qmfyiigait lnnlllrkdm
     1681 cswskgmqir ynvsqleewl rdknlmnsga ketlepliqa aqllqvkkkt dddaeaicsm
     1741 cnalttaqiv kvlnlytpvn efeervsvsf irtiqmrlrd rkdspqllmd akhifpvtfp
     1801 fnpsslalet iqipaslglg fisrv
//
LOCUS       XP_047288501            1749 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-Va isoform X5 [Homo sapiens].
ACCESSION   XP_047288501
VERSION     XP_047288501.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432545.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1749
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1749
                     /product="unconventional myosin-Va isoform X5"
                     /calculated_mol_wt=203418
     Region          1..620
                     /region_name="MYSc_Myo5"
                     /note="class V myosin, motor domain; cd01380"
                     /db_xref="CDD:276831"
     Region          5..1317
                     /region_name="COG5022"
                     /note="Myosin heavy chain [General function prediction
                     only]"
                     /db_xref="CDD:227355"
     Site            32..39
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276831"
     Site            78..88
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276831"
     Site            306..314
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276831"
     Site            order(335..346,349..358)
                     /site_type="active"
                     /note="relay loop [active]"
                     /db_xref="CDD:276831"
     Site            554..564
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276831"
     Site            order(575..585,605..620)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276831"
     Region          1375..1749
                     /region_name="Myo5a_CBD"
                     /note="Cargo binding domain of myosin 5a; cd15478"
                     /db_xref="CDD:271262"
     Site            order(1392..1394,1397..1400,1570..1571,1729,1734,1736,
                     1738..1740)
                     /site_type="other"
                     /note="RILPL2 interface [polypeptide binding]"
                     /db_xref="CDD:271262"
     Site            order(1420,1423..1424,1427..1428,1431..1432,1435,1466,
                     1484..1489,1491..1492,1495)
                     /site_type="other"
                     /note="melanophilin interface [polypeptide binding]"
                     /db_xref="CDD:271262"
     CDS             1..1749
                     /gene="MYO5A"
                     /gene_synonym="GS1; MYH12; MYO5; MYR12"
                     /coded_by="XM_047432545.1:383..5632"
                     /db_xref="GeneID:4644"
                     /db_xref="HGNC:HGNC:7602"
                     /db_xref="MIM:160777"
ORIGIN      
        1 mgdmdphifa vaeeaykqma rdernqsiiv sgesgagktv sakyamryfa tvsgsasean
       61 veekvlasnp imesignakt trndnssrfg kyieigfdkr yriiganmrt ylleksrvvf
      121 qaeeernyhi fyqlcasakl pefkmlrlgn adnfnytkqg gspviegvdd akemahtrqa
      181 ctllgisesh qmgifrilag ilhlgnvgft srdadsctip pkheplcifc elmgvdyeem
      241 chwlchrkla tatetyikpi sklqatnard alakhiyakl fnwivdnvnq alhsavkqhs
      301 figvldiygf etfeinsfeq fcinyanekl qqqfnmhvfk leqeeymkeq ipwtlidfyd
      361 nqpcinlies klgildllde eckmpkgtdd twaqklynth lnkcalfekp rlsnkafiiq
      421 hfadkveyqc egfleknkdt vfeeqikvlk sskfkmlpel fqddekaisp tsatssgrtp
      481 ltrtpakptk grpgqmakeh kktvghqfrn slhllmetln attphyvrci kpndfkfpft
      541 fdekravqql racgvletir isaagfpsrw tyqeffsryr vlmkqkdvls drkqtcknvl
      601 eklildkdky qfgktkiffr agqvaylekl radklraaci riqktirgwl lrkkylrmrk
      661 aaitmqryvr gyqarcyakf lrrtkaatii qkywrmyvvr rrykirraat ivlqsylrgf
      721 larnryrkil rehkaviiqk rvrgwlarth ykrsmhaiiy lqccfrrmma krelkklkie
      781 arsverykkl higmenkimq lqrkvdeqnk dykclveklt nlegiynset eklrsdlerl
      841 qlseeeakva tgrvlslqee iaklrkdleq trsekkciee hadrykqete qlvsnlkeen
      901 tllkqekeal nhrivqqake mtetmekklv eetkqleldl nderlryqnl lnefsrleer
      961 yddlkeemtl mvhvpkpghk rtdsthssne seyifsseia emedipsrte epsekkvpld
     1021 mslflklqkr vteleqekqv mqdeldrkee qvlrskakee erpqirgael eyeslkrqel
     1081 esenkklkne lnelrkalse ksapevtapg apayrvlmeq ltsvseeldv rkeevlilrs
     1141 qlvsqkeaiq pkddkntmtd stilledvqk mkdkgeiaqa yiglketnrs saldyhelne
     1201 dgelwlvyeg lkqanrlles qlqsqkrshe neaealrgei qslkeennrq qqllaqnlql
     1261 ppearieasl qheitrltne nlyfeelyad dpkkyqsyri slykrmidlm eqlekqdktv
     1321 rklkkqlkvf akkigelevg qmenispgqi idepirpvni prkekdfqgm leykkedeqk
     1381 lvknlilelk prgvavnlip glpayilfmc vrhadylndd qkvrslltst insikkvlkk
     1441 rgddfetvsf wlsntcrflh clkqysgeeg fmkhntsrqn ehcltnfdla eyrqvlsdla
     1501 iqiyqqlvrv lenilqpmiv sgmlehetiq gvsgvkptgl rkrtssiade gtytldsilr
     1561 qlnsfhsvmc qhgmdpelik qvvkqmfyii gaitlnnlll rkdmcswskg mqirynvsql
     1621 eewlrdknlm nsgaketlep liqaaqllqv kkktdddaea icsmcnaltt aqivkvlnly
     1681 tpvnefeerv svsfirtiqm rlrdrkdspq llmdakhifp vtfpfnpssl aletiqipas
     1741 lglgfisrv
//
LOCUS       XP_047288502            1642 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-Va isoform X6 [Homo sapiens].
ACCESSION   XP_047288502
VERSION     XP_047288502.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432546.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1642
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1642
                     /product="unconventional myosin-Va isoform X6"
                     /calculated_mol_wt=191717
     Region          <1..513
                     /region_name="Motor_domain"
                     /note="Myosin and Kinesin motor domain; cl22853"
                     /db_xref="CDD:473979"
     Region          2..1210
                     /region_name="COG5022"
                     /note="Myosin heavy chain [General function prediction
                     only]"
                     /db_xref="CDD:227355"
     Region          1268..1642
                     /region_name="Myo5a_CBD"
                     /note="Cargo binding domain of myosin 5a; cd15478"
                     /db_xref="CDD:271262"
     Site            order(1285..1287,1290..1293,1463..1464,1622,1627,1629,
                     1631..1633)
                     /site_type="other"
                     /note="RILPL2 interface [polypeptide binding]"
                     /db_xref="CDD:271262"
     Site            order(1313,1316..1317,1320..1321,1324..1325,1328,1359,
                     1377..1382,1384..1385,1388)
                     /site_type="other"
                     /note="melanophilin interface [polypeptide binding]"
                     /db_xref="CDD:271262"
     CDS             1..1642
                     /gene="MYO5A"
                     /gene_synonym="GS1; MYH12; MYO5; MYR12"
                     /coded_by="XM_047432546.1:1094..6022"
                     /db_xref="GeneID:4644"
                     /db_xref="HGNC:HGNC:7602"
                     /db_xref="MIM:160777"
ORIGIN      
        1 mrtylleksr vvfqaeeern yhifyqlcas aklpefkmlr lgnadnfnyt kqggspvieg
       61 vddakemaht rqactllgis eshqmgifri lagilhlgnv gftsrdadsc tippkheplc
      121 ifcelmgvdy eemchwlchr klatatetyi kpisklqatn ardalakhiy aklfnwivdn
      181 vnqalhsavk qhsfigvldi ygfetfeins feqfcinyan eklqqqfnmh vfkleqeeym
      241 keqipwtlid fydnqpcinl iesklgildl ldeeckmpkg tddtwaqkly nthlnkcalf
      301 ekprlsnkaf iiqhfadkve yqcegflekn kdtvfeeqik vlksskfkml pelfqddeka
      361 isptsatssg rtpltrtpak ptkgrpgqma kehkktvghq frnslhllme tlnattphyv
      421 rcikpndfkf pftfdekrav qqlracgvle tirisaagfp srwtyqeffs ryrvlmkqkd
      481 vlsdrkqtck nvleklildk dkyqfgktki ffragqvayl eklradklra aciriqktir
      541 gwllrkkylr mrkaaitmqr yvrgyqarcy akflrrtkaa tiiqkywrmy vvrrrykirr
      601 aativlqsyl rgflarnryr kilrehkavi iqkrvrgwla rthykrsmha iiylqccfrr
      661 mmakrelkkl kiearsvery kklhigmenk imqlqrkvde qnkdykclve kltnlegiyn
      721 seteklrsdl erlqlseeea kvatgrvlsl qeeiaklrkd leqtrsekkc ieehadrykq
      781 eteqlvsnlk eentllkqek ealnhrivqq akemtetmek klveetkqle ldlnderlry
      841 qnllnefsrl eeryddlkee mtlmvhvpkp ghkrtdsths sneseyifss eiaemedips
      901 rteepsekkv pldmslflkl qkrvteleqe kqvmqdeldr keeqvlrska keeerpqirg
      961 aeleyeslkr qelesenkkl knelnelrka lseksapevt apgapayrvl meqltsvsee
     1021 ldvrkeevli lrsqlvsqke aiqpkddknt mtdstilled vqkmkdkgei aqayiglket
     1081 nrssaldyhe lnedgelwlv yeglkqanrl lesqlqsqkr sheneaealr geiqslkeen
     1141 nrqqqllaqn lqlppearie aslqheitrl tnenlyfeel yaddpkkyqs yrislykrmi
     1201 dlmeqlekqd ktvrklkkql kvfakkigel evgqmenisp gqiidepirp vniprkekdf
     1261 qgmleykked eqklvknlil elkprgvavn lipglpayil fmcvrhadyl nddqkvrsll
     1321 tstinsikkv lkkrgddfet vsfwlsntcr flhclkqysg eegfmkhnts rqnehcltnf
     1381 dlaeyrqvls dlaiqiyqql vrvlenilqp mivsgmlehe tiqgvsgvkp tglrkrtssi
     1441 adegtytlds ilrqlnsfhs vmcqhgmdpe likqvvkqmf yiigaitlnn lllrkdmcsw
     1501 skgmqirynv sqleewlrdk nlmnsgaket lepliqaaql lqvkkktddd aeaicsmcna
     1561 lttaqivkvl nlytpvnefe ervsvsfirt iqmrlrdrkd spqllmdakh ifpvtfpfnp
     1621 sslaletiqi paslglgfis rv
//
LOCUS       XP_011519915            2638 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-IXa isoform X1 [Homo sapiens].
ACCESSION   XP_011519915
VERSION     XP_011519915.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521613.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2638
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2638
                     /product="unconventional myosin-IXa isoform X1"
                     /calculated_mol_wt=302459
     Region          15..110
                     /region_name="RA_Myosin-IXa"
                     /note="Ras-associating (RA) domain found in Myosin-IXa;
                     cd17216"
                     /db_xref="CDD:340736"
     Region          160..1004
                     /region_name="MYSc_Myo9"
                     /note="class IX myosin, motor domain; cd01385"
                     /db_xref="CDD:276836"
     Site            order(187..195,239..246,285..295,537..542)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276836"
     Site            187..195
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276836"
     Site            239..246
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276836"
     Site            285..295
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276836"
     Site            480
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:276836"
     Site            537..542
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276836"
     Site            order(566..577,580..589)
                     /site_type="active"
                     /note="relay loop [active]"
                     /db_xref="CDD:276836"
     Site            940..949
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276836"
     Site            order(952..979,983..1004)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276836"
     Region          2067..2124
                     /region_name="C1_Myosin-IXa"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in unconventional myosin-IXa and similar proteins;
                     cd20883"
                     /db_xref="CDD:410433"
     Region          2133..2318
                     /region_name="RhoGAP_myosin_IX"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain present in class IX myosins. Class
                     IX myosins contain a characteristic head domain, a neck
                     domain, a tail domain which contains a C6H2-zinc binding
                     motif and a RhoGAP domain. Class...; cd04377"
                     /db_xref="CDD:239842"
     Site            order(2170,2207,2211,2280,2283..2284,2309)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239842"
     Site            2170
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239842"
     CDS             1..2638
                     /gene="MYO9A"
                     /gene_synonym="CMS24"
                     /coded_by="XM_011521613.4:543..8459"
                     /db_xref="GeneID:4649"
                     /db_xref="HGNC:HGNC:7608"
                     /db_xref="MIM:604875"
ORIGIN      
        1 mnindggrrr fednehtlri ypgaisegti ycpiparkns taaeviesli nklhldktkc
       61 yvlaevkefg geewilnptd cpvqrmmlwp rmalenrlsg edyrfllrek nldgsihygs
      121 lqswlrvtee rrrmmergfl pqpqqkdfdd lcslpdlnek tllenlrnrf khekiytyvg
      181 silivinpfk flpiynpkyv kmydnhqlgk lephiyavad vayhamlqrk knqcivisge
      241 sgsgktqstn flihhltals qkgfasgveq iilgagpvle afgnaktahn nnssrfgkfi
      301 qvnyqetgtv lgayvekyll eksrlvyqeh nernyhvfyy llagaseder safhlkqpee
      361 yhylnqitkk plrqswddyc ydsepdcftv egedlrhdfe rlqlamemvg flpktrrqif
      421 sllsailhlg nicykkktyr ddsidicnpe vlpivselle vkeemlfeal vtrktvtvge
      481 klilpyklae avtvrnsmak slysalfdwi vfrinhalln skdlehntkt lsigvldifg
      541 fedyennsfe qfcinfaner lqhyfnqhif kleqeeyrte giswhnidyi dntccinlis
      601 kkptgllhll deesnfpqat nqtlldkfkh qhednsyief pavmepafii khyagkvkyg
      661 vkdfrekntd hmrpdivall rssknafisg migidpvavf rwailraffr amvafreagk
      721 rnihrktghd dtapcailks mdsfsflqhp vhqrsleilq rckeekysit rknprtplsd
      781 lqgmnalnek nqhdtfdiaw ngrtgirqsr lssgtslldk dgifanstss kllerahgil
      841 trnknfkskp alpkhllevn slkhltrltl qdritksllh lhkkkkppsi saqfqaslsk
      901 lmetlgqaep yfvkcirsna eklplrfsdv lvlrqlrytg mletvrirqs gysskysfqd
      961 fvshfhvllp rniipskfni qdffrkinln pdnyqvgktm vflkeqerqh lqdllhqevl
     1021 rriillqrwf rvllcrqhfl hlrqasviiq rfwrnylnqk qvrdaavqkd afvmasaaal
     1081 lqaswrahle rqrylelraa aiviqqkwrd yyrrrhmaai ciqarwkayr eskryqeqrk
     1141 kiillqstcr gfrarqrfka lkeqrlretk pevglvnikg ygsleiqgsd psgwedcsfd
     1201 nrikaieeck sviesnrisr essvdclkes pnkqqeraqs qsgvdlqedv lvrerprsle
     1261 dlhqkkvgra kresrrmrel eqaifslell kvrslggisp sedrrwstel vpeglqsprg
     1321 tpdsessqgs lellsyeesq ksklesvisd egdlqfpspk issspkfdsr dnalsasnet
     1381 ssaehlkdgt mkemvvcsse sitckpqlkd sfisnslptf fyipqqdplk tnsqldtsiq
     1441 rnkllenedt agealtldin retrryhcsg kdqivpslnt essnpvlkkl eklntekeer
     1501 qkqlqqqnek emmeqirqqt dilekerkaf ktiekprige clvapssyqs kqrverpssl
     1561 lslntsnkge lnvlgslslk daalaqkdss sahlppkdrp vtvfferkgs pcqsstvkel
     1621 sktdrmgtql nvacklsnnr iskrehfrpt qsyshnsddl sregnarpif ftpkdnmsip
     1681 lvskealnsk npqlhkedep awkpvklagp gqreqvarpa hkkkarmart rsdfltrgtf
     1741 adgegdteed dyddiiepll sldqashcel gpapslgqas hsdsemtsqr fssvdeqakl
     1801 hktmsqgeit klavrqkasd sdirpqrakm rfwakgkqge kkttrvkptt qsevsplfag
     1861 tdvipahqfp delaayhptp plspelpgsc rkefkenkep spkakrkrsv kisnvaldsm
     1921 hwqndsvqii asvsdlksmd efllkkvndl dnedskkdtl vdvvfkkalk efrqnifsfy
     1981 ssalamddgk sirykdlyal feqilektmr leqrdslges pvrvwvntfk vfldeymnef
     2041 ktsdctatkv pkterkkrrk ketdlveehn ghifkatqys iptyceycss liwimdrasv
     2101 cklckyachk kcclkttakc skkydpelss rqfgvelsrl tsedrtvplv veklinyiem
     2161 hglytegiyr ksgstnkike lrqgldtdae svnlddynih viasvfkqwl rdlpnplmtf
     2221 elyeeflram glqerketir gvysvidqls rthlntlerl ifhlvrialq edtnrmsana
     2281 laivfapcil rcpdttdplq svqdiskttt cvelivveqm nkykarlkdi sslefaenka
     2341 ktrlslirrs mkpvliavrf mnitrnsvsg kgrirrgnyp gpsspvvvrl psvsdvseet
     2401 ltseaametd iteqqqaamq qeervlteqi enlqkekeel tfemlvlepr asddetlese
     2461 asigtadsse nlnmeseyai sekserslal sslktagkse pssklrkqlk kqqdsldvvd
     2521 ssvsslclsn tasshgtrkl fqiyskspfy raasgnealg megplgqtkf ledkpqfisr
     2581 gtfnpekgkq klknvknspq ktketpegtv msgrrktvdp dctsnqqlal fgnnefmv
//
LOCUS       XP_011519918            2638 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-IXa isoform X1 [Homo sapiens].
ACCESSION   XP_011519918
VERSION     XP_011519918.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521616.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2638
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2638
                     /product="unconventional myosin-IXa isoform X1"
                     /calculated_mol_wt=302459
     Region          15..110
                     /region_name="RA_Myosin-IXa"
                     /note="Ras-associating (RA) domain found in Myosin-IXa;
                     cd17216"
                     /db_xref="CDD:340736"
     Region          160..1004
                     /region_name="MYSc_Myo9"
                     /note="class IX myosin, motor domain; cd01385"
                     /db_xref="CDD:276836"
     Site            order(187..195,239..246,285..295,537..542)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276836"
     Site            187..195
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276836"
     Site            239..246
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276836"
     Site            285..295
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276836"
     Site            480
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:276836"
     Site            537..542
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276836"
     Site            order(566..577,580..589)
                     /site_type="active"
                     /note="relay loop [active]"
                     /db_xref="CDD:276836"
     Site            940..949
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276836"
     Site            order(952..979,983..1004)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276836"
     Region          2067..2124
                     /region_name="C1_Myosin-IXa"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in unconventional myosin-IXa and similar proteins;
                     cd20883"
                     /db_xref="CDD:410433"
     Region          2133..2318
                     /region_name="RhoGAP_myosin_IX"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain present in class IX myosins. Class
                     IX myosins contain a characteristic head domain, a neck
                     domain, a tail domain which contains a C6H2-zinc binding
                     motif and a RhoGAP domain. Class...; cd04377"
                     /db_xref="CDD:239842"
     Site            order(2170,2207,2211,2280,2283..2284,2309)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239842"
     Site            2170
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239842"
     CDS             1..2638
                     /gene="MYO9A"
                     /gene_synonym="CMS24"
                     /coded_by="XM_011521616.4:140..8056"
                     /db_xref="GeneID:4649"
                     /db_xref="HGNC:HGNC:7608"
                     /db_xref="MIM:604875"
ORIGIN      
        1 mnindggrrr fednehtlri ypgaisegti ycpiparkns taaeviesli nklhldktkc
       61 yvlaevkefg geewilnptd cpvqrmmlwp rmalenrlsg edyrfllrek nldgsihygs
      121 lqswlrvtee rrrmmergfl pqpqqkdfdd lcslpdlnek tllenlrnrf khekiytyvg
      181 silivinpfk flpiynpkyv kmydnhqlgk lephiyavad vayhamlqrk knqcivisge
      241 sgsgktqstn flihhltals qkgfasgveq iilgagpvle afgnaktahn nnssrfgkfi
      301 qvnyqetgtv lgayvekyll eksrlvyqeh nernyhvfyy llagaseder safhlkqpee
      361 yhylnqitkk plrqswddyc ydsepdcftv egedlrhdfe rlqlamemvg flpktrrqif
      421 sllsailhlg nicykkktyr ddsidicnpe vlpivselle vkeemlfeal vtrktvtvge
      481 klilpyklae avtvrnsmak slysalfdwi vfrinhalln skdlehntkt lsigvldifg
      541 fedyennsfe qfcinfaner lqhyfnqhif kleqeeyrte giswhnidyi dntccinlis
      601 kkptgllhll deesnfpqat nqtlldkfkh qhednsyief pavmepafii khyagkvkyg
      661 vkdfrekntd hmrpdivall rssknafisg migidpvavf rwailraffr amvafreagk
      721 rnihrktghd dtapcailks mdsfsflqhp vhqrsleilq rckeekysit rknprtplsd
      781 lqgmnalnek nqhdtfdiaw ngrtgirqsr lssgtslldk dgifanstss kllerahgil
      841 trnknfkskp alpkhllevn slkhltrltl qdritksllh lhkkkkppsi saqfqaslsk
      901 lmetlgqaep yfvkcirsna eklplrfsdv lvlrqlrytg mletvrirqs gysskysfqd
      961 fvshfhvllp rniipskfni qdffrkinln pdnyqvgktm vflkeqerqh lqdllhqevl
     1021 rriillqrwf rvllcrqhfl hlrqasviiq rfwrnylnqk qvrdaavqkd afvmasaaal
     1081 lqaswrahle rqrylelraa aiviqqkwrd yyrrrhmaai ciqarwkayr eskryqeqrk
     1141 kiillqstcr gfrarqrfka lkeqrlretk pevglvnikg ygsleiqgsd psgwedcsfd
     1201 nrikaieeck sviesnrisr essvdclkes pnkqqeraqs qsgvdlqedv lvrerprsle
     1261 dlhqkkvgra kresrrmrel eqaifslell kvrslggisp sedrrwstel vpeglqsprg
     1321 tpdsessqgs lellsyeesq ksklesvisd egdlqfpspk issspkfdsr dnalsasnet
     1381 ssaehlkdgt mkemvvcsse sitckpqlkd sfisnslptf fyipqqdplk tnsqldtsiq
     1441 rnkllenedt agealtldin retrryhcsg kdqivpslnt essnpvlkkl eklntekeer
     1501 qkqlqqqnek emmeqirqqt dilekerkaf ktiekprige clvapssyqs kqrverpssl
     1561 lslntsnkge lnvlgslslk daalaqkdss sahlppkdrp vtvfferkgs pcqsstvkel
     1621 sktdrmgtql nvacklsnnr iskrehfrpt qsyshnsddl sregnarpif ftpkdnmsip
     1681 lvskealnsk npqlhkedep awkpvklagp gqreqvarpa hkkkarmart rsdfltrgtf
     1741 adgegdteed dyddiiepll sldqashcel gpapslgqas hsdsemtsqr fssvdeqakl
     1801 hktmsqgeit klavrqkasd sdirpqrakm rfwakgkqge kkttrvkptt qsevsplfag
     1861 tdvipahqfp delaayhptp plspelpgsc rkefkenkep spkakrkrsv kisnvaldsm
     1921 hwqndsvqii asvsdlksmd efllkkvndl dnedskkdtl vdvvfkkalk efrqnifsfy
     1981 ssalamddgk sirykdlyal feqilektmr leqrdslges pvrvwvntfk vfldeymnef
     2041 ktsdctatkv pkterkkrrk ketdlveehn ghifkatqys iptyceycss liwimdrasv
     2101 cklckyachk kcclkttakc skkydpelss rqfgvelsrl tsedrtvplv veklinyiem
     2161 hglytegiyr ksgstnkike lrqgldtdae svnlddynih viasvfkqwl rdlpnplmtf
     2221 elyeeflram glqerketir gvysvidqls rthlntlerl ifhlvrialq edtnrmsana
     2281 laivfapcil rcpdttdplq svqdiskttt cvelivveqm nkykarlkdi sslefaenka
     2341 ktrlslirrs mkpvliavrf mnitrnsvsg kgrirrgnyp gpsspvvvrl psvsdvseet
     2401 ltseaametd iteqqqaamq qeervlteqi enlqkekeel tfemlvlepr asddetlese
     2461 asigtadsse nlnmeseyai sekserslal sslktagkse pssklrkqlk kqqdsldvvd
     2521 ssvsslclsn tasshgtrkl fqiyskspfy raasgnealg megplgqtkf ledkpqfisr
     2581 gtfnpekgkq klknvknspq ktketpegtv msgrrktvdp dctsnqqlal fgnnefmv
//
LOCUS       XP_011519916            2638 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-IXa isoform X1 [Homo sapiens].
ACCESSION   XP_011519916
VERSION     XP_011519916.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521614.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2638
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2638
                     /product="unconventional myosin-IXa isoform X1"
                     /calculated_mol_wt=302459
     Region          15..110
                     /region_name="RA_Myosin-IXa"
                     /note="Ras-associating (RA) domain found in Myosin-IXa;
                     cd17216"
                     /db_xref="CDD:340736"
     Region          160..1004
                     /region_name="MYSc_Myo9"
                     /note="class IX myosin, motor domain; cd01385"
                     /db_xref="CDD:276836"
     Site            order(187..195,239..246,285..295,537..542)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276836"
     Site            187..195
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276836"
     Site            239..246
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276836"
     Site            285..295
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276836"
     Site            480
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:276836"
     Site            537..542
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276836"
     Site            order(566..577,580..589)
                     /site_type="active"
                     /note="relay loop [active]"
                     /db_xref="CDD:276836"
     Site            940..949
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276836"
     Site            order(952..979,983..1004)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276836"
     Region          2067..2124
                     /region_name="C1_Myosin-IXa"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in unconventional myosin-IXa and similar proteins;
                     cd20883"
                     /db_xref="CDD:410433"
     Region          2133..2318
                     /region_name="RhoGAP_myosin_IX"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain present in class IX myosins. Class
                     IX myosins contain a characteristic head domain, a neck
                     domain, a tail domain which contains a C6H2-zinc binding
                     motif and a RhoGAP domain. Class...; cd04377"
                     /db_xref="CDD:239842"
     Site            order(2170,2207,2211,2280,2283..2284,2309)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239842"
     Site            2170
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239842"
     CDS             1..2638
                     /gene="MYO9A"
                     /gene_synonym="CMS24"
                     /coded_by="XM_011521614.4:588..8504"
                     /db_xref="GeneID:4649"
                     /db_xref="HGNC:HGNC:7608"
                     /db_xref="MIM:604875"
ORIGIN      
        1 mnindggrrr fednehtlri ypgaisegti ycpiparkns taaeviesli nklhldktkc
       61 yvlaevkefg geewilnptd cpvqrmmlwp rmalenrlsg edyrfllrek nldgsihygs
      121 lqswlrvtee rrrmmergfl pqpqqkdfdd lcslpdlnek tllenlrnrf khekiytyvg
      181 silivinpfk flpiynpkyv kmydnhqlgk lephiyavad vayhamlqrk knqcivisge
      241 sgsgktqstn flihhltals qkgfasgveq iilgagpvle afgnaktahn nnssrfgkfi
      301 qvnyqetgtv lgayvekyll eksrlvyqeh nernyhvfyy llagaseder safhlkqpee
      361 yhylnqitkk plrqswddyc ydsepdcftv egedlrhdfe rlqlamemvg flpktrrqif
      421 sllsailhlg nicykkktyr ddsidicnpe vlpivselle vkeemlfeal vtrktvtvge
      481 klilpyklae avtvrnsmak slysalfdwi vfrinhalln skdlehntkt lsigvldifg
      541 fedyennsfe qfcinfaner lqhyfnqhif kleqeeyrte giswhnidyi dntccinlis
      601 kkptgllhll deesnfpqat nqtlldkfkh qhednsyief pavmepafii khyagkvkyg
      661 vkdfrekntd hmrpdivall rssknafisg migidpvavf rwailraffr amvafreagk
      721 rnihrktghd dtapcailks mdsfsflqhp vhqrsleilq rckeekysit rknprtplsd
      781 lqgmnalnek nqhdtfdiaw ngrtgirqsr lssgtslldk dgifanstss kllerahgil
      841 trnknfkskp alpkhllevn slkhltrltl qdritksllh lhkkkkppsi saqfqaslsk
      901 lmetlgqaep yfvkcirsna eklplrfsdv lvlrqlrytg mletvrirqs gysskysfqd
      961 fvshfhvllp rniipskfni qdffrkinln pdnyqvgktm vflkeqerqh lqdllhqevl
     1021 rriillqrwf rvllcrqhfl hlrqasviiq rfwrnylnqk qvrdaavqkd afvmasaaal
     1081 lqaswrahle rqrylelraa aiviqqkwrd yyrrrhmaai ciqarwkayr eskryqeqrk
     1141 kiillqstcr gfrarqrfka lkeqrlretk pevglvnikg ygsleiqgsd psgwedcsfd
     1201 nrikaieeck sviesnrisr essvdclkes pnkqqeraqs qsgvdlqedv lvrerprsle
     1261 dlhqkkvgra kresrrmrel eqaifslell kvrslggisp sedrrwstel vpeglqsprg
     1321 tpdsessqgs lellsyeesq ksklesvisd egdlqfpspk issspkfdsr dnalsasnet
     1381 ssaehlkdgt mkemvvcsse sitckpqlkd sfisnslptf fyipqqdplk tnsqldtsiq
     1441 rnkllenedt agealtldin retrryhcsg kdqivpslnt essnpvlkkl eklntekeer
     1501 qkqlqqqnek emmeqirqqt dilekerkaf ktiekprige clvapssyqs kqrverpssl
     1561 lslntsnkge lnvlgslslk daalaqkdss sahlppkdrp vtvfferkgs pcqsstvkel
     1621 sktdrmgtql nvacklsnnr iskrehfrpt qsyshnsddl sregnarpif ftpkdnmsip
     1681 lvskealnsk npqlhkedep awkpvklagp gqreqvarpa hkkkarmart rsdfltrgtf
     1741 adgegdteed dyddiiepll sldqashcel gpapslgqas hsdsemtsqr fssvdeqakl
     1801 hktmsqgeit klavrqkasd sdirpqrakm rfwakgkqge kkttrvkptt qsevsplfag
     1861 tdvipahqfp delaayhptp plspelpgsc rkefkenkep spkakrkrsv kisnvaldsm
     1921 hwqndsvqii asvsdlksmd efllkkvndl dnedskkdtl vdvvfkkalk efrqnifsfy
     1981 ssalamddgk sirykdlyal feqilektmr leqrdslges pvrvwvntfk vfldeymnef
     2041 ktsdctatkv pkterkkrrk ketdlveehn ghifkatqys iptyceycss liwimdrasv
     2101 cklckyachk kcclkttakc skkydpelss rqfgvelsrl tsedrtvplv veklinyiem
     2161 hglytegiyr ksgstnkike lrqgldtdae svnlddynih viasvfkqwl rdlpnplmtf
     2221 elyeeflram glqerketir gvysvidqls rthlntlerl ifhlvrialq edtnrmsana
     2281 laivfapcil rcpdttdplq svqdiskttt cvelivveqm nkykarlkdi sslefaenka
     2341 ktrlslirrs mkpvliavrf mnitrnsvsg kgrirrgnyp gpsspvvvrl psvsdvseet
     2401 ltseaametd iteqqqaamq qeervlteqi enlqkekeel tfemlvlepr asddetlese
     2461 asigtadsse nlnmeseyai sekserslal sslktagkse pssklrkqlk kqqdsldvvd
     2521 ssvsslclsn tasshgtrkl fqiyskspfy raasgnealg megplgqtkf ledkpqfisr
     2581 gtfnpekgkq klknvknspq ktketpegtv msgrrktvdp dctsnqqlal fgnnefmv
//
LOCUS       XP_011519917            2638 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-IXa isoform X1 [Homo sapiens].
ACCESSION   XP_011519917
VERSION     XP_011519917.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521615.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2638
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2638
                     /product="unconventional myosin-IXa isoform X1"
                     /calculated_mol_wt=302459
     Region          15..110
                     /region_name="RA_Myosin-IXa"
                     /note="Ras-associating (RA) domain found in Myosin-IXa;
                     cd17216"
                     /db_xref="CDD:340736"
     Region          160..1004
                     /region_name="MYSc_Myo9"
                     /note="class IX myosin, motor domain; cd01385"
                     /db_xref="CDD:276836"
     Site            order(187..195,239..246,285..295,537..542)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276836"
     Site            187..195
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276836"
     Site            239..246
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276836"
     Site            285..295
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276836"
     Site            480
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:276836"
     Site            537..542
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276836"
     Site            order(566..577,580..589)
                     /site_type="active"
                     /note="relay loop [active]"
                     /db_xref="CDD:276836"
     Site            940..949
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276836"
     Site            order(952..979,983..1004)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276836"
     Region          2067..2124
                     /region_name="C1_Myosin-IXa"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in unconventional myosin-IXa and similar proteins;
                     cd20883"
                     /db_xref="CDD:410433"
     Region          2133..2318
                     /region_name="RhoGAP_myosin_IX"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain present in class IX myosins. Class
                     IX myosins contain a characteristic head domain, a neck
                     domain, a tail domain which contains a C6H2-zinc binding
                     motif and a RhoGAP domain. Class...; cd04377"
                     /db_xref="CDD:239842"
     Site            order(2170,2207,2211,2280,2283..2284,2309)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239842"
     Site            2170
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239842"
     CDS             1..2638
                     /gene="MYO9A"
                     /gene_synonym="CMS24"
                     /coded_by="XM_011521615.4:346..8262"
                     /db_xref="GeneID:4649"
                     /db_xref="HGNC:HGNC:7608"
                     /db_xref="MIM:604875"
ORIGIN      
        1 mnindggrrr fednehtlri ypgaisegti ycpiparkns taaeviesli nklhldktkc
       61 yvlaevkefg geewilnptd cpvqrmmlwp rmalenrlsg edyrfllrek nldgsihygs
      121 lqswlrvtee rrrmmergfl pqpqqkdfdd lcslpdlnek tllenlrnrf khekiytyvg
      181 silivinpfk flpiynpkyv kmydnhqlgk lephiyavad vayhamlqrk knqcivisge
      241 sgsgktqstn flihhltals qkgfasgveq iilgagpvle afgnaktahn nnssrfgkfi
      301 qvnyqetgtv lgayvekyll eksrlvyqeh nernyhvfyy llagaseder safhlkqpee
      361 yhylnqitkk plrqswddyc ydsepdcftv egedlrhdfe rlqlamemvg flpktrrqif
      421 sllsailhlg nicykkktyr ddsidicnpe vlpivselle vkeemlfeal vtrktvtvge
      481 klilpyklae avtvrnsmak slysalfdwi vfrinhalln skdlehntkt lsigvldifg
      541 fedyennsfe qfcinfaner lqhyfnqhif kleqeeyrte giswhnidyi dntccinlis
      601 kkptgllhll deesnfpqat nqtlldkfkh qhednsyief pavmepafii khyagkvkyg
      661 vkdfrekntd hmrpdivall rssknafisg migidpvavf rwailraffr amvafreagk
      721 rnihrktghd dtapcailks mdsfsflqhp vhqrsleilq rckeekysit rknprtplsd
      781 lqgmnalnek nqhdtfdiaw ngrtgirqsr lssgtslldk dgifanstss kllerahgil
      841 trnknfkskp alpkhllevn slkhltrltl qdritksllh lhkkkkppsi saqfqaslsk
      901 lmetlgqaep yfvkcirsna eklplrfsdv lvlrqlrytg mletvrirqs gysskysfqd
      961 fvshfhvllp rniipskfni qdffrkinln pdnyqvgktm vflkeqerqh lqdllhqevl
     1021 rriillqrwf rvllcrqhfl hlrqasviiq rfwrnylnqk qvrdaavqkd afvmasaaal
     1081 lqaswrahle rqrylelraa aiviqqkwrd yyrrrhmaai ciqarwkayr eskryqeqrk
     1141 kiillqstcr gfrarqrfka lkeqrlretk pevglvnikg ygsleiqgsd psgwedcsfd
     1201 nrikaieeck sviesnrisr essvdclkes pnkqqeraqs qsgvdlqedv lvrerprsle
     1261 dlhqkkvgra kresrrmrel eqaifslell kvrslggisp sedrrwstel vpeglqsprg
     1321 tpdsessqgs lellsyeesq ksklesvisd egdlqfpspk issspkfdsr dnalsasnet
     1381 ssaehlkdgt mkemvvcsse sitckpqlkd sfisnslptf fyipqqdplk tnsqldtsiq
     1441 rnkllenedt agealtldin retrryhcsg kdqivpslnt essnpvlkkl eklntekeer
     1501 qkqlqqqnek emmeqirqqt dilekerkaf ktiekprige clvapssyqs kqrverpssl
     1561 lslntsnkge lnvlgslslk daalaqkdss sahlppkdrp vtvfferkgs pcqsstvkel
     1621 sktdrmgtql nvacklsnnr iskrehfrpt qsyshnsddl sregnarpif ftpkdnmsip
     1681 lvskealnsk npqlhkedep awkpvklagp gqreqvarpa hkkkarmart rsdfltrgtf
     1741 adgegdteed dyddiiepll sldqashcel gpapslgqas hsdsemtsqr fssvdeqakl
     1801 hktmsqgeit klavrqkasd sdirpqrakm rfwakgkqge kkttrvkptt qsevsplfag
     1861 tdvipahqfp delaayhptp plspelpgsc rkefkenkep spkakrkrsv kisnvaldsm
     1921 hwqndsvqii asvsdlksmd efllkkvndl dnedskkdtl vdvvfkkalk efrqnifsfy
     1981 ssalamddgk sirykdlyal feqilektmr leqrdslges pvrvwvntfk vfldeymnef
     2041 ktsdctatkv pkterkkrrk ketdlveehn ghifkatqys iptyceycss liwimdrasv
     2101 cklckyachk kcclkttakc skkydpelss rqfgvelsrl tsedrtvplv veklinyiem
     2161 hglytegiyr ksgstnkike lrqgldtdae svnlddynih viasvfkqwl rdlpnplmtf
     2221 elyeeflram glqerketir gvysvidqls rthlntlerl ifhlvrialq edtnrmsana
     2281 laivfapcil rcpdttdplq svqdiskttt cvelivveqm nkykarlkdi sslefaenka
     2341 ktrlslirrs mkpvliavrf mnitrnsvsg kgrirrgnyp gpsspvvvrl psvsdvseet
     2401 ltseaametd iteqqqaamq qeervlteqi enlqkekeel tfemlvlepr asddetlese
     2461 asigtadsse nlnmeseyai sekserslal sslktagkse pssklrkqlk kqqdsldvvd
     2521 ssvsslclsn tasshgtrkl fqiyskspfy raasgnealg megplgqtkf ledkpqfisr
     2581 gtfnpekgkq klknvknspq ktketpegtv msgrrktvdp dctsnqqlal fgnnefmv
//
LOCUS       XP_011519919            2637 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-IXa isoform X2 [Homo sapiens].
ACCESSION   XP_011519919
VERSION     XP_011519919.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521617.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2637
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2637
                     /product="unconventional myosin-IXa isoform X2"
                     /calculated_mol_wt=302331
     Region          15..110
                     /region_name="RA_Myosin-IXa"
                     /note="Ras-associating (RA) domain found in Myosin-IXa;
                     cd17216"
                     /db_xref="CDD:340736"
     Region          160..1004
                     /region_name="MYSc_Myo9"
                     /note="class IX myosin, motor domain; cd01385"
                     /db_xref="CDD:276836"
     Site            order(187..195,239..246,285..295,537..542)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276836"
     Site            187..195
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276836"
     Site            239..246
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276836"
     Site            285..295
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276836"
     Site            480
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:276836"
     Site            537..542
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276836"
     Site            order(566..577,580..589)
                     /site_type="active"
                     /note="relay loop [active]"
                     /db_xref="CDD:276836"
     Site            940..949
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276836"
     Site            order(952..979,983..1004)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276836"
     Region          2066..2123
                     /region_name="C1_Myosin-IXa"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in unconventional myosin-IXa and similar proteins;
                     cd20883"
                     /db_xref="CDD:410433"
     Region          2132..2317
                     /region_name="RhoGAP_myosin_IX"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain present in class IX myosins. Class
                     IX myosins contain a characteristic head domain, a neck
                     domain, a tail domain which contains a C6H2-zinc binding
                     motif and a RhoGAP domain. Class...; cd04377"
                     /db_xref="CDD:239842"
     Site            order(2169,2206,2210,2279,2282..2283,2308)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239842"
     Site            2169
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239842"
     CDS             1..2637
                     /gene="MYO9A"
                     /gene_synonym="CMS24"
                     /coded_by="XM_011521617.4:543..8456"
                     /db_xref="GeneID:4649"
                     /db_xref="HGNC:HGNC:7608"
                     /db_xref="MIM:604875"
ORIGIN      
        1 mnindggrrr fednehtlri ypgaisegti ycpiparkns taaeviesli nklhldktkc
       61 yvlaevkefg geewilnptd cpvqrmmlwp rmalenrlsg edyrfllrek nldgsihygs
      121 lqswlrvtee rrrmmergfl pqpqqkdfdd lcslpdlnek tllenlrnrf khekiytyvg
      181 silivinpfk flpiynpkyv kmydnhqlgk lephiyavad vayhamlqrk knqcivisge
      241 sgsgktqstn flihhltals qkgfasgveq iilgagpvle afgnaktahn nnssrfgkfi
      301 qvnyqetgtv lgayvekyll eksrlvyqeh nernyhvfyy llagaseder safhlkqpee
      361 yhylnqitkk plrqswddyc ydsepdcftv egedlrhdfe rlqlamemvg flpktrrqif
      421 sllsailhlg nicykkktyr ddsidicnpe vlpivselle vkeemlfeal vtrktvtvge
      481 klilpyklae avtvrnsmak slysalfdwi vfrinhalln skdlehntkt lsigvldifg
      541 fedyennsfe qfcinfaner lqhyfnqhif kleqeeyrte giswhnidyi dntccinlis
      601 kkptgllhll deesnfpqat nqtlldkfkh qhednsyief pavmepafii khyagkvkyg
      661 vkdfrekntd hmrpdivall rssknafisg migidpvavf rwailraffr amvafreagk
      721 rnihrktghd dtapcailks mdsfsflqhp vhqrsleilq rckeekysit rknprtplsd
      781 lqgmnalnek nqhdtfdiaw ngrtgirqsr lssgtslldk dgifanstss kllerahgil
      841 trnknfkskp alpkhllevn slkhltrltl qdritksllh lhkkkkppsi saqfqaslsk
      901 lmetlgqaep yfvkcirsna eklplrfsdv lvlrqlrytg mletvrirqs gysskysfqd
      961 fvshfhvllp rniipskfni qdffrkinln pdnyqvgktm vflkeqerqh lqdllhqevl
     1021 rriillqrwf rvllcrqhfl hlrqasviiq rfwrnylnqk qvrdaavqkd afvmasaaal
     1081 lqaswrahle rqrylelraa aiviqqkwrd yyrrrhmaai ciqarwkayr eskryqeqrk
     1141 kiillqstcr gfrarqrfka lkeqrlretk pevglvnikg ygsleiqgsd psgwedcsfd
     1201 nrikaieeck sviesnrisr essvdclkes pnkqqeraqs qsgvdlqedv lvrerprsle
     1261 dlhqkkvgra kresrrmrel eqaifslell kvrslggisp sedrrwstel vpeglqsprg
     1321 tpdsessqgs lellsyeesq ksklesvisd egdlqfpspk issspkfdsr dnalsasnet
     1381 ssaehlkdgt mkemvvcsse sitckpqlkd sfisnslptf fyipqqdplk tnsqldtsiq
     1441 rnkllenedt agealtldin retrryhcsg kdqivpslnt essnpvlkkl eklntekeer
     1501 qkqlqqqnek emmeqirqqt dilekerkaf ktiekprige clvapssyqs kqrverpssl
     1561 lslntsnkge lnvlgslslk daalaqkdss sahlppkdrp vtvfferkgs pcqsstvkel
     1621 sktdrmgtql nvacklsnnr iskrehfrpt qsyshnsddl sregnarpif ftpkdnmsip
     1681 lvskealnsk npqlhkedep awkpvklagp gqrevarpah kkkarmartr sdfltrgtfa
     1741 dgegdteedd yddiieplls ldqashcelg papslgqash sdsemtsqrf ssvdeqaklh
     1801 ktmsqgeitk lavrqkasds dirpqrakmr fwakgkqgek kttrvkpttq sevsplfagt
     1861 dvipahqfpd elaayhptpp lspelpgscr kefkenkeps pkakrkrsvk isnvaldsmh
     1921 wqndsvqiia svsdlksmde fllkkvndld nedskkdtlv dvvfkkalke frqnifsfys
     1981 salamddgks irykdlyalf eqilektmrl eqrdslgesp vrvwvntfkv fldeymnefk
     2041 tsdctatkvp kterkkrrkk etdlveehng hifkatqysi ptyceycssl iwimdrasvc
     2101 klckyachkk cclkttakcs kkydpelssr qfgvelsrlt sedrtvplvv eklinyiemh
     2161 glytegiyrk sgstnkikel rqgldtdaes vnlddynihv iasvfkqwlr dlpnplmtfe
     2221 lyeeflramg lqerketirg vysvidqlsr thlntlerli fhlvrialqe dtnrmsanal
     2281 aivfapcilr cpdttdplqs vqdisktttc velivveqmn kykarlkdis slefaenkak
     2341 trlslirrsm kpvliavrfm nitrnsvsgk grirrgnypg psspvvvrlp svsdvseetl
     2401 tseaametdi teqqqaamqq eervlteqie nlqkekeelt femlvlepra sddetlesea
     2461 sigtadssen lnmeseyais ekserslals slktagksep ssklrkqlkk qqdsldvvds
     2521 svsslclsnt asshgtrklf qiyskspfyr aasgnealgm egplgqtkfl edkpqfisrg
     2581 tfnpekgkqk lknvknspqk tketpegtvm sgrrktvdpd ctsnqqlalf gnnefmv
//
LOCUS       XP_047288503            2637 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-IXa isoform X2 [Homo sapiens].
ACCESSION   XP_047288503
VERSION     XP_047288503.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432547.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2637
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2637
                     /product="unconventional myosin-IXa isoform X2"
                     /calculated_mol_wt=302331
     Region          15..110
                     /region_name="RA_Myosin-IXa"
                     /note="Ras-associating (RA) domain found in Myosin-IXa;
                     cd17216"
                     /db_xref="CDD:340736"
     Region          160..1004
                     /region_name="MYSc_Myo9"
                     /note="class IX myosin, motor domain; cd01385"
                     /db_xref="CDD:276836"
     Site            order(187..195,239..246,285..295,537..542)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276836"
     Site            187..195
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276836"
     Site            239..246
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276836"
     Site            285..295
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276836"
     Site            480
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:276836"
     Site            537..542
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276836"
     Site            order(566..577,580..589)
                     /site_type="active"
                     /note="relay loop [active]"
                     /db_xref="CDD:276836"
     Site            940..949
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276836"
     Site            order(952..979,983..1004)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276836"
     Region          2066..2123
                     /region_name="C1_Myosin-IXa"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in unconventional myosin-IXa and similar proteins;
                     cd20883"
                     /db_xref="CDD:410433"
     Region          2132..2317
                     /region_name="RhoGAP_myosin_IX"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain present in class IX myosins. Class
                     IX myosins contain a characteristic head domain, a neck
                     domain, a tail domain which contains a C6H2-zinc binding
                     motif and a RhoGAP domain. Class...; cd04377"
                     /db_xref="CDD:239842"
     Site            order(2169,2206,2210,2279,2282..2283,2308)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239842"
     Site            2169
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239842"
     CDS             1..2637
                     /gene="MYO9A"
                     /gene_synonym="CMS24"
                     /coded_by="XM_047432547.1:140..8053"
                     /db_xref="GeneID:4649"
                     /db_xref="HGNC:HGNC:7608"
                     /db_xref="MIM:604875"
ORIGIN      
        1 mnindggrrr fednehtlri ypgaisegti ycpiparkns taaeviesli nklhldktkc
       61 yvlaevkefg geewilnptd cpvqrmmlwp rmalenrlsg edyrfllrek nldgsihygs
      121 lqswlrvtee rrrmmergfl pqpqqkdfdd lcslpdlnek tllenlrnrf khekiytyvg
      181 silivinpfk flpiynpkyv kmydnhqlgk lephiyavad vayhamlqrk knqcivisge
      241 sgsgktqstn flihhltals qkgfasgveq iilgagpvle afgnaktahn nnssrfgkfi
      301 qvnyqetgtv lgayvekyll eksrlvyqeh nernyhvfyy llagaseder safhlkqpee
      361 yhylnqitkk plrqswddyc ydsepdcftv egedlrhdfe rlqlamemvg flpktrrqif
      421 sllsailhlg nicykkktyr ddsidicnpe vlpivselle vkeemlfeal vtrktvtvge
      481 klilpyklae avtvrnsmak slysalfdwi vfrinhalln skdlehntkt lsigvldifg
      541 fedyennsfe qfcinfaner lqhyfnqhif kleqeeyrte giswhnidyi dntccinlis
      601 kkptgllhll deesnfpqat nqtlldkfkh qhednsyief pavmepafii khyagkvkyg
      661 vkdfrekntd hmrpdivall rssknafisg migidpvavf rwailraffr amvafreagk
      721 rnihrktghd dtapcailks mdsfsflqhp vhqrsleilq rckeekysit rknprtplsd
      781 lqgmnalnek nqhdtfdiaw ngrtgirqsr lssgtslldk dgifanstss kllerahgil
      841 trnknfkskp alpkhllevn slkhltrltl qdritksllh lhkkkkppsi saqfqaslsk
      901 lmetlgqaep yfvkcirsna eklplrfsdv lvlrqlrytg mletvrirqs gysskysfqd
      961 fvshfhvllp rniipskfni qdffrkinln pdnyqvgktm vflkeqerqh lqdllhqevl
     1021 rriillqrwf rvllcrqhfl hlrqasviiq rfwrnylnqk qvrdaavqkd afvmasaaal
     1081 lqaswrahle rqrylelraa aiviqqkwrd yyrrrhmaai ciqarwkayr eskryqeqrk
     1141 kiillqstcr gfrarqrfka lkeqrlretk pevglvnikg ygsleiqgsd psgwedcsfd
     1201 nrikaieeck sviesnrisr essvdclkes pnkqqeraqs qsgvdlqedv lvrerprsle
     1261 dlhqkkvgra kresrrmrel eqaifslell kvrslggisp sedrrwstel vpeglqsprg
     1321 tpdsessqgs lellsyeesq ksklesvisd egdlqfpspk issspkfdsr dnalsasnet
     1381 ssaehlkdgt mkemvvcsse sitckpqlkd sfisnslptf fyipqqdplk tnsqldtsiq
     1441 rnkllenedt agealtldin retrryhcsg kdqivpslnt essnpvlkkl eklntekeer
     1501 qkqlqqqnek emmeqirqqt dilekerkaf ktiekprige clvapssyqs kqrverpssl
     1561 lslntsnkge lnvlgslslk daalaqkdss sahlppkdrp vtvfferkgs pcqsstvkel
     1621 sktdrmgtql nvacklsnnr iskrehfrpt qsyshnsddl sregnarpif ftpkdnmsip
     1681 lvskealnsk npqlhkedep awkpvklagp gqrevarpah kkkarmartr sdfltrgtfa
     1741 dgegdteedd yddiieplls ldqashcelg papslgqash sdsemtsqrf ssvdeqaklh
     1801 ktmsqgeitk lavrqkasds dirpqrakmr fwakgkqgek kttrvkpttq sevsplfagt
     1861 dvipahqfpd elaayhptpp lspelpgscr kefkenkeps pkakrkrsvk isnvaldsmh
     1921 wqndsvqiia svsdlksmde fllkkvndld nedskkdtlv dvvfkkalke frqnifsfys
     1981 salamddgks irykdlyalf eqilektmrl eqrdslgesp vrvwvntfkv fldeymnefk
     2041 tsdctatkvp kterkkrrkk etdlveehng hifkatqysi ptyceycssl iwimdrasvc
     2101 klckyachkk cclkttakcs kkydpelssr qfgvelsrlt sedrtvplvv eklinyiemh
     2161 glytegiyrk sgstnkikel rqgldtdaes vnlddynihv iasvfkqwlr dlpnplmtfe
     2221 lyeeflramg lqerketirg vysvidqlsr thlntlerli fhlvrialqe dtnrmsanal
     2281 aivfapcilr cpdttdplqs vqdisktttc velivveqmn kykarlkdis slefaenkak
     2341 trlslirrsm kpvliavrfm nitrnsvsgk grirrgnypg psspvvvrlp svsdvseetl
     2401 tseaametdi teqqqaamqq eervlteqie nlqkekeelt femlvlepra sddetlesea
     2461 sigtadssen lnmeseyais ekserslals slktagksep ssklrkqlkk qqdsldvvds
     2521 svsslclsnt asshgtrklf qiyskspfyr aasgnealgm egplgqtkfl edkpqfisrg
     2581 tfnpekgkqk lknvknspqk tketpegtvm sgrrktvdpd ctsnqqlalf gnnefmv
//
LOCUS       XP_047288504            2637 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-IXa isoform X2 [Homo sapiens].
ACCESSION   XP_047288504
VERSION     XP_047288504.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432548.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2637
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2637
                     /product="unconventional myosin-IXa isoform X2"
                     /calculated_mol_wt=302331
     Region          15..110
                     /region_name="RA_Myosin-IXa"
                     /note="Ras-associating (RA) domain found in Myosin-IXa;
                     cd17216"
                     /db_xref="CDD:340736"
     Region          160..1004
                     /region_name="MYSc_Myo9"
                     /note="class IX myosin, motor domain; cd01385"
                     /db_xref="CDD:276836"
     Site            order(187..195,239..246,285..295,537..542)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276836"
     Site            187..195
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276836"
     Site            239..246
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276836"
     Site            285..295
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276836"
     Site            480
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:276836"
     Site            537..542
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276836"
     Site            order(566..577,580..589)
                     /site_type="active"
                     /note="relay loop [active]"
                     /db_xref="CDD:276836"
     Site            940..949
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276836"
     Site            order(952..979,983..1004)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276836"
     Region          2066..2123
                     /region_name="C1_Myosin-IXa"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in unconventional myosin-IXa and similar proteins;
                     cd20883"
                     /db_xref="CDD:410433"
     Region          2132..2317
                     /region_name="RhoGAP_myosin_IX"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain present in class IX myosins. Class
                     IX myosins contain a characteristic head domain, a neck
                     domain, a tail domain which contains a C6H2-zinc binding
                     motif and a RhoGAP domain. Class...; cd04377"
                     /db_xref="CDD:239842"
     Site            order(2169,2206,2210,2279,2282..2283,2308)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239842"
     Site            2169
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239842"
     CDS             1..2637
                     /gene="MYO9A"
                     /gene_synonym="CMS24"
                     /coded_by="XM_047432548.1:588..8501"
                     /db_xref="GeneID:4649"
                     /db_xref="HGNC:HGNC:7608"
                     /db_xref="MIM:604875"
ORIGIN      
        1 mnindggrrr fednehtlri ypgaisegti ycpiparkns taaeviesli nklhldktkc
       61 yvlaevkefg geewilnptd cpvqrmmlwp rmalenrlsg edyrfllrek nldgsihygs
      121 lqswlrvtee rrrmmergfl pqpqqkdfdd lcslpdlnek tllenlrnrf khekiytyvg
      181 silivinpfk flpiynpkyv kmydnhqlgk lephiyavad vayhamlqrk knqcivisge
      241 sgsgktqstn flihhltals qkgfasgveq iilgagpvle afgnaktahn nnssrfgkfi
      301 qvnyqetgtv lgayvekyll eksrlvyqeh nernyhvfyy llagaseder safhlkqpee
      361 yhylnqitkk plrqswddyc ydsepdcftv egedlrhdfe rlqlamemvg flpktrrqif
      421 sllsailhlg nicykkktyr ddsidicnpe vlpivselle vkeemlfeal vtrktvtvge
      481 klilpyklae avtvrnsmak slysalfdwi vfrinhalln skdlehntkt lsigvldifg
      541 fedyennsfe qfcinfaner lqhyfnqhif kleqeeyrte giswhnidyi dntccinlis
      601 kkptgllhll deesnfpqat nqtlldkfkh qhednsyief pavmepafii khyagkvkyg
      661 vkdfrekntd hmrpdivall rssknafisg migidpvavf rwailraffr amvafreagk
      721 rnihrktghd dtapcailks mdsfsflqhp vhqrsleilq rckeekysit rknprtplsd
      781 lqgmnalnek nqhdtfdiaw ngrtgirqsr lssgtslldk dgifanstss kllerahgil
      841 trnknfkskp alpkhllevn slkhltrltl qdritksllh lhkkkkppsi saqfqaslsk
      901 lmetlgqaep yfvkcirsna eklplrfsdv lvlrqlrytg mletvrirqs gysskysfqd
      961 fvshfhvllp rniipskfni qdffrkinln pdnyqvgktm vflkeqerqh lqdllhqevl
     1021 rriillqrwf rvllcrqhfl hlrqasviiq rfwrnylnqk qvrdaavqkd afvmasaaal
     1081 lqaswrahle rqrylelraa aiviqqkwrd yyrrrhmaai ciqarwkayr eskryqeqrk
     1141 kiillqstcr gfrarqrfka lkeqrlretk pevglvnikg ygsleiqgsd psgwedcsfd
     1201 nrikaieeck sviesnrisr essvdclkes pnkqqeraqs qsgvdlqedv lvrerprsle
     1261 dlhqkkvgra kresrrmrel eqaifslell kvrslggisp sedrrwstel vpeglqsprg
     1321 tpdsessqgs lellsyeesq ksklesvisd egdlqfpspk issspkfdsr dnalsasnet
     1381 ssaehlkdgt mkemvvcsse sitckpqlkd sfisnslptf fyipqqdplk tnsqldtsiq
     1441 rnkllenedt agealtldin retrryhcsg kdqivpslnt essnpvlkkl eklntekeer
     1501 qkqlqqqnek emmeqirqqt dilekerkaf ktiekprige clvapssyqs kqrverpssl
     1561 lslntsnkge lnvlgslslk daalaqkdss sahlppkdrp vtvfferkgs pcqsstvkel
     1621 sktdrmgtql nvacklsnnr iskrehfrpt qsyshnsddl sregnarpif ftpkdnmsip
     1681 lvskealnsk npqlhkedep awkpvklagp gqrevarpah kkkarmartr sdfltrgtfa
     1741 dgegdteedd yddiieplls ldqashcelg papslgqash sdsemtsqrf ssvdeqaklh
     1801 ktmsqgeitk lavrqkasds dirpqrakmr fwakgkqgek kttrvkpttq sevsplfagt
     1861 dvipahqfpd elaayhptpp lspelpgscr kefkenkeps pkakrkrsvk isnvaldsmh
     1921 wqndsvqiia svsdlksmde fllkkvndld nedskkdtlv dvvfkkalke frqnifsfys
     1981 salamddgks irykdlyalf eqilektmrl eqrdslgesp vrvwvntfkv fldeymnefk
     2041 tsdctatkvp kterkkrrkk etdlveehng hifkatqysi ptyceycssl iwimdrasvc
     2101 klckyachkk cclkttakcs kkydpelssr qfgvelsrlt sedrtvplvv eklinyiemh
     2161 glytegiyrk sgstnkikel rqgldtdaes vnlddynihv iasvfkqwlr dlpnplmtfe
     2221 lyeeflramg lqerketirg vysvidqlsr thlntlerli fhlvrialqe dtnrmsanal
     2281 aivfapcilr cpdttdplqs vqdisktttc velivveqmn kykarlkdis slefaenkak
     2341 trlslirrsm kpvliavrfm nitrnsvsgk grirrgnypg psspvvvrlp svsdvseetl
     2401 tseaametdi teqqqaamqq eervlteqie nlqkekeelt femlvlepra sddetlesea
     2461 sigtadssen lnmeseyais ekserslals slktagksep ssklrkqlkk qqdsldvvds
     2521 svsslclsnt asshgtrklf qiyskspfyr aasgnealgm egplgqtkfl edkpqfisrg
     2581 tfnpekgkqk lknvknspqk tketpegtvm sgrrktvdpd ctsnqqlalf gnnefmv
//
LOCUS       XP_011519920            2620 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-IXa isoform X3 [Homo sapiens].
ACCESSION   XP_011519920
VERSION     XP_011519920.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521618.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2620
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2620
                     /product="unconventional myosin-IXa isoform X3"
                     /calculated_mol_wt=300432
     Region          15..110
                     /region_name="RA_Myosin-IXa"
                     /note="Ras-associating (RA) domain found in Myosin-IXa;
                     cd17216"
                     /db_xref="CDD:340736"
     Region          160..1004
                     /region_name="MYSc_Myo9"
                     /note="class IX myosin, motor domain; cd01385"
                     /db_xref="CDD:276836"
     Site            order(187..195,239..246,285..295,537..542)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276836"
     Site            187..195
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276836"
     Site            239..246
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276836"
     Site            285..295
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276836"
     Site            480
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:276836"
     Site            537..542
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276836"
     Site            order(566..577,580..589)
                     /site_type="active"
                     /note="relay loop [active]"
                     /db_xref="CDD:276836"
     Site            940..949
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276836"
     Site            order(952..979,983..1004)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276836"
     Region          2067..2124
                     /region_name="C1_Myosin-IXa"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in unconventional myosin-IXa and similar proteins;
                     cd20883"
                     /db_xref="CDD:410433"
     Region          2133..2318
                     /region_name="RhoGAP_myosin_IX"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain present in class IX myosins. Class
                     IX myosins contain a characteristic head domain, a neck
                     domain, a tail domain which contains a C6H2-zinc binding
                     motif and a RhoGAP domain. Class...; cd04377"
                     /db_xref="CDD:239842"
     Site            order(2170,2207,2211,2280,2283..2284,2309)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239842"
     Site            2170
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239842"
     CDS             1..2620
                     /gene="MYO9A"
                     /gene_synonym="CMS24"
                     /coded_by="XM_011521618.4:543..8405"
                     /db_xref="GeneID:4649"
                     /db_xref="HGNC:HGNC:7608"
                     /db_xref="MIM:604875"
ORIGIN      
        1 mnindggrrr fednehtlri ypgaisegti ycpiparkns taaeviesli nklhldktkc
       61 yvlaevkefg geewilnptd cpvqrmmlwp rmalenrlsg edyrfllrek nldgsihygs
      121 lqswlrvtee rrrmmergfl pqpqqkdfdd lcslpdlnek tllenlrnrf khekiytyvg
      181 silivinpfk flpiynpkyv kmydnhqlgk lephiyavad vayhamlqrk knqcivisge
      241 sgsgktqstn flihhltals qkgfasgveq iilgagpvle afgnaktahn nnssrfgkfi
      301 qvnyqetgtv lgayvekyll eksrlvyqeh nernyhvfyy llagaseder safhlkqpee
      361 yhylnqitkk plrqswddyc ydsepdcftv egedlrhdfe rlqlamemvg flpktrrqif
      421 sllsailhlg nicykkktyr ddsidicnpe vlpivselle vkeemlfeal vtrktvtvge
      481 klilpyklae avtvrnsmak slysalfdwi vfrinhalln skdlehntkt lsigvldifg
      541 fedyennsfe qfcinfaner lqhyfnqhif kleqeeyrte giswhnidyi dntccinlis
      601 kkptgllhll deesnfpqat nqtlldkfkh qhednsyief pavmepafii khyagkvkyg
      661 vkdfrekntd hmrpdivall rssknafisg migidpvavf rwailraffr amvafreagk
      721 rnihrktghd dtapcailks mdsfsflqhp vhqrsleilq rckeekysit rknprtplsd
      781 lqgmnalnek nqhdtfdiaw ngrtgirqsr lssgtslldk dgifanstss kllerahgil
      841 trnknfkskp alpkhllevn slkhltrltl qdritksllh lhkkkkppsi saqfqaslsk
      901 lmetlgqaep yfvkcirsna eklplrfsdv lvlrqlrytg mletvrirqs gysskysfqd
      961 fvshfhvllp rniipskfni qdffrkinln pdnyqvgktm vflkeqerqh lqdllhqevl
     1021 rriillqrwf rvllcrqhfl hlrqasviiq rfwrnylnqk qvrdaavqkd afvmasaaal
     1081 lqaswrahle rqrylelraa aiviqqkwrd yyrrrhmaai ciqarwkayr eskryqeqrk
     1141 kiillqstcr gfrarqrfka lkeqrlretk pevglvnikg ygsleiqgsd psgwedcsfd
     1201 nrikaieeck sviesnrisr essvdclkes pnkqqeraqs qsgvdlqedv lvrerprsle
     1261 dlhqkkvgra kresrrmrel eqaifslell kvrslggisp sedrrwstel vpeglqsprg
     1321 tpdsessqgs lellsyeesq ksklesvisd egdlqfpspk issspkfdsr dnalsasnet
     1381 ssaehlkdgt mkemvvcsse sitckpqlkd sfisnslptf fyipqqdplk tnsqldtsiq
     1441 rnkllenedt agealtldin retrryhcsg kdqivpslnt essnpvlkkl eklntekeer
     1501 qkqlqqqnek emmeqirqqt dilekerkaf ktiekprige clvapssyqs kqrverpssl
     1561 lslntsnkge lnvlgslslk daalaqkdss sahlppkdrp vtvfferkgs pcqsstvkel
     1621 sktdrmgtql nvacklsnnr iskrehfrpt qsyshnsddl sregnarpif ftpkdnmsip
     1681 lvskealnsk npqlhkedep awkpvklagp gqreqvarpa hkkkarmart rsdfltrgtf
     1741 adgegdteed dyddiiepll sldqashcel gpapslgqas hsdsemtsqr fssvdeqakl
     1801 hktmsqgeit klavrqkasd sdirpqrakm rfwakgkqge kkttrvkptt qsevsplfag
     1861 tdvipahqfp delaayhptp plspelpgsc rkefkenkep spkakrkrsv kisnvaldsm
     1921 hwqndsvqii asvsdlksmd efllkkvndl dnedskkdtl vdvvfkkalk efrqnifsfy
     1981 ssalamddgk sirykdlyal feqilektmr leqrdslges pvrvwvntfk vfldeymnef
     2041 ktsdctatkv pkterkkrrk ketdlveehn ghifkatqys iptyceycss liwimdrasv
     2101 cklckyachk kcclkttakc skkydpelss rqfgvelsrl tsedrtvplv veklinyiem
     2161 hglytegiyr ksgstnkike lrqgldtdae svnlddynih viasvfkqwl rdlpnplmtf
     2221 elyeeflram glqerketir gvysvidqls rthlntlerl ifhlvrialq edtnrmsana
     2281 laivfapcil rcpdttdplq svqdiskttt cvelivveqm nkykarlkdi sslefaenka
     2341 ktrlslirrs mgkgrirrgn ypgpsspvvv rlpsvsdvse etltseaame tditeqqqaa
     2401 mqqeervlte qienlqkeke eltfemlvle prasddetle seasigtads senlnmesey
     2461 aiseksersl alsslktagk sepssklrkq lkkqqdsldv vdssvsslcl sntasshgtr
     2521 klfqiysksp fyraasgnea lgmegplgqt kfledkpqfi srgtfnpekg kqklknvkns
     2581 pqktketpeg tvmsgrrktv dpdctsnqql alfgnnefmv
//
LOCUS       XP_006720602            2619 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-IXa isoform X4 [Homo sapiens].
ACCESSION   XP_006720602
VERSION     XP_006720602.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720539.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2619
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2619
                     /product="unconventional myosin-IXa isoform X4"
                     /calculated_mol_wt=300303
     Region          15..110
                     /region_name="RA_Myosin-IXa"
                     /note="Ras-associating (RA) domain found in Myosin-IXa;
                     cd17216"
                     /db_xref="CDD:340736"
     Region          160..1004
                     /region_name="MYSc_Myo9"
                     /note="class IX myosin, motor domain; cd01385"
                     /db_xref="CDD:276836"
     Site            order(187..195,239..246,285..295,537..542)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276836"
     Site            187..195
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276836"
     Site            239..246
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276836"
     Site            285..295
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276836"
     Site            480
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:276836"
     Site            537..542
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276836"
     Site            order(566..577,580..589)
                     /site_type="active"
                     /note="relay loop [active]"
                     /db_xref="CDD:276836"
     Site            940..949
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276836"
     Site            order(952..979,983..1004)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276836"
     Region          2066..2123
                     /region_name="C1_Myosin-IXa"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in unconventional myosin-IXa and similar proteins;
                     cd20883"
                     /db_xref="CDD:410433"
     Region          2132..2317
                     /region_name="RhoGAP_myosin_IX"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain present in class IX myosins. Class
                     IX myosins contain a characteristic head domain, a neck
                     domain, a tail domain which contains a C6H2-zinc binding
                     motif and a RhoGAP domain. Class...; cd04377"
                     /db_xref="CDD:239842"
     Site            order(2169,2206,2210,2279,2282..2283,2308)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239842"
     Site            2169
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239842"
     CDS             1..2619
                     /gene="MYO9A"
                     /gene_synonym="CMS24"
                     /coded_by="XM_006720539.4:543..8402"
                     /db_xref="GeneID:4649"
                     /db_xref="HGNC:HGNC:7608"
                     /db_xref="MIM:604875"
ORIGIN      
        1 mnindggrrr fednehtlri ypgaisegti ycpiparkns taaeviesli nklhldktkc
       61 yvlaevkefg geewilnptd cpvqrmmlwp rmalenrlsg edyrfllrek nldgsihygs
      121 lqswlrvtee rrrmmergfl pqpqqkdfdd lcslpdlnek tllenlrnrf khekiytyvg
      181 silivinpfk flpiynpkyv kmydnhqlgk lephiyavad vayhamlqrk knqcivisge
      241 sgsgktqstn flihhltals qkgfasgveq iilgagpvle afgnaktahn nnssrfgkfi
      301 qvnyqetgtv lgayvekyll eksrlvyqeh nernyhvfyy llagaseder safhlkqpee
      361 yhylnqitkk plrqswddyc ydsepdcftv egedlrhdfe rlqlamemvg flpktrrqif
      421 sllsailhlg nicykkktyr ddsidicnpe vlpivselle vkeemlfeal vtrktvtvge
      481 klilpyklae avtvrnsmak slysalfdwi vfrinhalln skdlehntkt lsigvldifg
      541 fedyennsfe qfcinfaner lqhyfnqhif kleqeeyrte giswhnidyi dntccinlis
      601 kkptgllhll deesnfpqat nqtlldkfkh qhednsyief pavmepafii khyagkvkyg
      661 vkdfrekntd hmrpdivall rssknafisg migidpvavf rwailraffr amvafreagk
      721 rnihrktghd dtapcailks mdsfsflqhp vhqrsleilq rckeekysit rknprtplsd
      781 lqgmnalnek nqhdtfdiaw ngrtgirqsr lssgtslldk dgifanstss kllerahgil
      841 trnknfkskp alpkhllevn slkhltrltl qdritksllh lhkkkkppsi saqfqaslsk
      901 lmetlgqaep yfvkcirsna eklplrfsdv lvlrqlrytg mletvrirqs gysskysfqd
      961 fvshfhvllp rniipskfni qdffrkinln pdnyqvgktm vflkeqerqh lqdllhqevl
     1021 rriillqrwf rvllcrqhfl hlrqasviiq rfwrnylnqk qvrdaavqkd afvmasaaal
     1081 lqaswrahle rqrylelraa aiviqqkwrd yyrrrhmaai ciqarwkayr eskryqeqrk
     1141 kiillqstcr gfrarqrfka lkeqrlretk pevglvnikg ygsleiqgsd psgwedcsfd
     1201 nrikaieeck sviesnrisr essvdclkes pnkqqeraqs qsgvdlqedv lvrerprsle
     1261 dlhqkkvgra kresrrmrel eqaifslell kvrslggisp sedrrwstel vpeglqsprg
     1321 tpdsessqgs lellsyeesq ksklesvisd egdlqfpspk issspkfdsr dnalsasnet
     1381 ssaehlkdgt mkemvvcsse sitckpqlkd sfisnslptf fyipqqdplk tnsqldtsiq
     1441 rnkllenedt agealtldin retrryhcsg kdqivpslnt essnpvlkkl eklntekeer
     1501 qkqlqqqnek emmeqirqqt dilekerkaf ktiekprige clvapssyqs kqrverpssl
     1561 lslntsnkge lnvlgslslk daalaqkdss sahlppkdrp vtvfferkgs pcqsstvkel
     1621 sktdrmgtql nvacklsnnr iskrehfrpt qsyshnsddl sregnarpif ftpkdnmsip
     1681 lvskealnsk npqlhkedep awkpvklagp gqrevarpah kkkarmartr sdfltrgtfa
     1741 dgegdteedd yddiieplls ldqashcelg papslgqash sdsemtsqrf ssvdeqaklh
     1801 ktmsqgeitk lavrqkasds dirpqrakmr fwakgkqgek kttrvkpttq sevsplfagt
     1861 dvipahqfpd elaayhptpp lspelpgscr kefkenkeps pkakrkrsvk isnvaldsmh
     1921 wqndsvqiia svsdlksmde fllkkvndld nedskkdtlv dvvfkkalke frqnifsfys
     1981 salamddgks irykdlyalf eqilektmrl eqrdslgesp vrvwvntfkv fldeymnefk
     2041 tsdctatkvp kterkkrrkk etdlveehng hifkatqysi ptyceycssl iwimdrasvc
     2101 klckyachkk cclkttakcs kkydpelssr qfgvelsrlt sedrtvplvv eklinyiemh
     2161 glytegiyrk sgstnkikel rqgldtdaes vnlddynihv iasvfkqwlr dlpnplmtfe
     2221 lyeeflramg lqerketirg vysvidqlsr thlntlerli fhlvrialqe dtnrmsanal
     2281 aivfapcilr cpdttdplqs vqdisktttc velivveqmn kykarlkdis slefaenkak
     2341 trlslirrsm gkgrirrgny pgpsspvvvr lpsvsdvsee tltseaamet diteqqqaam
     2401 qqeervlteq ienlqkekee ltfemlvlep rasddetles easigtadss enlnmeseya
     2461 iseksersla lsslktagks epssklrkql kkqqdsldvv dssvsslcls ntasshgtrk
     2521 lfqiyskspf yraasgneal gmegplgqtk fledkpqfis rgtfnpekgk qklknvknsp
     2581 qktketpegt vmsgrrktvd pdctsnqqla lfgnnefmv
//
LOCUS       XP_047288505            2619 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-IXa isoform X4 [Homo sapiens].
ACCESSION   XP_047288505
VERSION     XP_047288505.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432549.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2619
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2619
                     /product="unconventional myosin-IXa isoform X4"
                     /calculated_mol_wt=300303
     Region          15..110
                     /region_name="RA_Myosin-IXa"
                     /note="Ras-associating (RA) domain found in Myosin-IXa;
                     cd17216"
                     /db_xref="CDD:340736"
     Region          160..1004
                     /region_name="MYSc_Myo9"
                     /note="class IX myosin, motor domain; cd01385"
                     /db_xref="CDD:276836"
     Site            order(187..195,239..246,285..295,537..542)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276836"
     Site            187..195
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276836"
     Site            239..246
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276836"
     Site            285..295
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276836"
     Site            480
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:276836"
     Site            537..542
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276836"
     Site            order(566..577,580..589)
                     /site_type="active"
                     /note="relay loop [active]"
                     /db_xref="CDD:276836"
     Site            940..949
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276836"
     Site            order(952..979,983..1004)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276836"
     Region          2066..2123
                     /region_name="C1_Myosin-IXa"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in unconventional myosin-IXa and similar proteins;
                     cd20883"
                     /db_xref="CDD:410433"
     Region          2132..2317
                     /region_name="RhoGAP_myosin_IX"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain present in class IX myosins. Class
                     IX myosins contain a characteristic head domain, a neck
                     domain, a tail domain which contains a C6H2-zinc binding
                     motif and a RhoGAP domain. Class...; cd04377"
                     /db_xref="CDD:239842"
     Site            order(2169,2206,2210,2279,2282..2283,2308)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239842"
     Site            2169
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239842"
     CDS             1..2619
                     /gene="MYO9A"
                     /gene_synonym="CMS24"
                     /coded_by="XM_047432549.1:140..7999"
                     /db_xref="GeneID:4649"
                     /db_xref="HGNC:HGNC:7608"
                     /db_xref="MIM:604875"
ORIGIN      
        1 mnindggrrr fednehtlri ypgaisegti ycpiparkns taaeviesli nklhldktkc
       61 yvlaevkefg geewilnptd cpvqrmmlwp rmalenrlsg edyrfllrek nldgsihygs
      121 lqswlrvtee rrrmmergfl pqpqqkdfdd lcslpdlnek tllenlrnrf khekiytyvg
      181 silivinpfk flpiynpkyv kmydnhqlgk lephiyavad vayhamlqrk knqcivisge
      241 sgsgktqstn flihhltals qkgfasgveq iilgagpvle afgnaktahn nnssrfgkfi
      301 qvnyqetgtv lgayvekyll eksrlvyqeh nernyhvfyy llagaseder safhlkqpee
      361 yhylnqitkk plrqswddyc ydsepdcftv egedlrhdfe rlqlamemvg flpktrrqif
      421 sllsailhlg nicykkktyr ddsidicnpe vlpivselle vkeemlfeal vtrktvtvge
      481 klilpyklae avtvrnsmak slysalfdwi vfrinhalln skdlehntkt lsigvldifg
      541 fedyennsfe qfcinfaner lqhyfnqhif kleqeeyrte giswhnidyi dntccinlis
      601 kkptgllhll deesnfpqat nqtlldkfkh qhednsyief pavmepafii khyagkvkyg
      661 vkdfrekntd hmrpdivall rssknafisg migidpvavf rwailraffr amvafreagk
      721 rnihrktghd dtapcailks mdsfsflqhp vhqrsleilq rckeekysit rknprtplsd
      781 lqgmnalnek nqhdtfdiaw ngrtgirqsr lssgtslldk dgifanstss kllerahgil
      841 trnknfkskp alpkhllevn slkhltrltl qdritksllh lhkkkkppsi saqfqaslsk
      901 lmetlgqaep yfvkcirsna eklplrfsdv lvlrqlrytg mletvrirqs gysskysfqd
      961 fvshfhvllp rniipskfni qdffrkinln pdnyqvgktm vflkeqerqh lqdllhqevl
     1021 rriillqrwf rvllcrqhfl hlrqasviiq rfwrnylnqk qvrdaavqkd afvmasaaal
     1081 lqaswrahle rqrylelraa aiviqqkwrd yyrrrhmaai ciqarwkayr eskryqeqrk
     1141 kiillqstcr gfrarqrfka lkeqrlretk pevglvnikg ygsleiqgsd psgwedcsfd
     1201 nrikaieeck sviesnrisr essvdclkes pnkqqeraqs qsgvdlqedv lvrerprsle
     1261 dlhqkkvgra kresrrmrel eqaifslell kvrslggisp sedrrwstel vpeglqsprg
     1321 tpdsessqgs lellsyeesq ksklesvisd egdlqfpspk issspkfdsr dnalsasnet
     1381 ssaehlkdgt mkemvvcsse sitckpqlkd sfisnslptf fyipqqdplk tnsqldtsiq
     1441 rnkllenedt agealtldin retrryhcsg kdqivpslnt essnpvlkkl eklntekeer
     1501 qkqlqqqnek emmeqirqqt dilekerkaf ktiekprige clvapssyqs kqrverpssl
     1561 lslntsnkge lnvlgslslk daalaqkdss sahlppkdrp vtvfferkgs pcqsstvkel
     1621 sktdrmgtql nvacklsnnr iskrehfrpt qsyshnsddl sregnarpif ftpkdnmsip
     1681 lvskealnsk npqlhkedep awkpvklagp gqrevarpah kkkarmartr sdfltrgtfa
     1741 dgegdteedd yddiieplls ldqashcelg papslgqash sdsemtsqrf ssvdeqaklh
     1801 ktmsqgeitk lavrqkasds dirpqrakmr fwakgkqgek kttrvkpttq sevsplfagt
     1861 dvipahqfpd elaayhptpp lspelpgscr kefkenkeps pkakrkrsvk isnvaldsmh
     1921 wqndsvqiia svsdlksmde fllkkvndld nedskkdtlv dvvfkkalke frqnifsfys
     1981 salamddgks irykdlyalf eqilektmrl eqrdslgesp vrvwvntfkv fldeymnefk
     2041 tsdctatkvp kterkkrrkk etdlveehng hifkatqysi ptyceycssl iwimdrasvc
     2101 klckyachkk cclkttakcs kkydpelssr qfgvelsrlt sedrtvplvv eklinyiemh
     2161 glytegiyrk sgstnkikel rqgldtdaes vnlddynihv iasvfkqwlr dlpnplmtfe
     2221 lyeeflramg lqerketirg vysvidqlsr thlntlerli fhlvrialqe dtnrmsanal
     2281 aivfapcilr cpdttdplqs vqdisktttc velivveqmn kykarlkdis slefaenkak
     2341 trlslirrsm gkgrirrgny pgpsspvvvr lpsvsdvsee tltseaamet diteqqqaam
     2401 qqeervlteq ienlqkekee ltfemlvlep rasddetles easigtadss enlnmeseya
     2461 iseksersla lsslktagks epssklrkql kkqqdsldvv dssvsslcls ntasshgtrk
     2521 lfqiyskspf yraasgneal gmegplgqtk fledkpqfis rgtfnpekgk qklknvknsp
     2581 qktketpegt vmsgrrktvd pdctsnqqla lfgnnefmv
//
LOCUS       XP_047288506            2619 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-IXa isoform X4 [Homo sapiens].
ACCESSION   XP_047288506
VERSION     XP_047288506.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432550.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2619
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2619
                     /product="unconventional myosin-IXa isoform X4"
                     /calculated_mol_wt=300303
     Region          15..110
                     /region_name="RA_Myosin-IXa"
                     /note="Ras-associating (RA) domain found in Myosin-IXa;
                     cd17216"
                     /db_xref="CDD:340736"
     Region          160..1004
                     /region_name="MYSc_Myo9"
                     /note="class IX myosin, motor domain; cd01385"
                     /db_xref="CDD:276836"
     Site            order(187..195,239..246,285..295,537..542)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276836"
     Site            187..195
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276836"
     Site            239..246
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276836"
     Site            285..295
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276836"
     Site            480
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:276836"
     Site            537..542
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276836"
     Site            order(566..577,580..589)
                     /site_type="active"
                     /note="relay loop [active]"
                     /db_xref="CDD:276836"
     Site            940..949
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276836"
     Site            order(952..979,983..1004)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276836"
     Region          2066..2123
                     /region_name="C1_Myosin-IXa"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in unconventional myosin-IXa and similar proteins;
                     cd20883"
                     /db_xref="CDD:410433"
     Region          2132..2317
                     /region_name="RhoGAP_myosin_IX"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain present in class IX myosins. Class
                     IX myosins contain a characteristic head domain, a neck
                     domain, a tail domain which contains a C6H2-zinc binding
                     motif and a RhoGAP domain. Class...; cd04377"
                     /db_xref="CDD:239842"
     Site            order(2169,2206,2210,2279,2282..2283,2308)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239842"
     Site            2169
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239842"
     CDS             1..2619
                     /gene="MYO9A"
                     /gene_synonym="CMS24"
                     /coded_by="XM_047432550.1:588..8447"
                     /db_xref="GeneID:4649"
                     /db_xref="HGNC:HGNC:7608"
                     /db_xref="MIM:604875"
ORIGIN      
        1 mnindggrrr fednehtlri ypgaisegti ycpiparkns taaeviesli nklhldktkc
       61 yvlaevkefg geewilnptd cpvqrmmlwp rmalenrlsg edyrfllrek nldgsihygs
      121 lqswlrvtee rrrmmergfl pqpqqkdfdd lcslpdlnek tllenlrnrf khekiytyvg
      181 silivinpfk flpiynpkyv kmydnhqlgk lephiyavad vayhamlqrk knqcivisge
      241 sgsgktqstn flihhltals qkgfasgveq iilgagpvle afgnaktahn nnssrfgkfi
      301 qvnyqetgtv lgayvekyll eksrlvyqeh nernyhvfyy llagaseder safhlkqpee
      361 yhylnqitkk plrqswddyc ydsepdcftv egedlrhdfe rlqlamemvg flpktrrqif
      421 sllsailhlg nicykkktyr ddsidicnpe vlpivselle vkeemlfeal vtrktvtvge
      481 klilpyklae avtvrnsmak slysalfdwi vfrinhalln skdlehntkt lsigvldifg
      541 fedyennsfe qfcinfaner lqhyfnqhif kleqeeyrte giswhnidyi dntccinlis
      601 kkptgllhll deesnfpqat nqtlldkfkh qhednsyief pavmepafii khyagkvkyg
      661 vkdfrekntd hmrpdivall rssknafisg migidpvavf rwailraffr amvafreagk
      721 rnihrktghd dtapcailks mdsfsflqhp vhqrsleilq rckeekysit rknprtplsd
      781 lqgmnalnek nqhdtfdiaw ngrtgirqsr lssgtslldk dgifanstss kllerahgil
      841 trnknfkskp alpkhllevn slkhltrltl qdritksllh lhkkkkppsi saqfqaslsk
      901 lmetlgqaep yfvkcirsna eklplrfsdv lvlrqlrytg mletvrirqs gysskysfqd
      961 fvshfhvllp rniipskfni qdffrkinln pdnyqvgktm vflkeqerqh lqdllhqevl
     1021 rriillqrwf rvllcrqhfl hlrqasviiq rfwrnylnqk qvrdaavqkd afvmasaaal
     1081 lqaswrahle rqrylelraa aiviqqkwrd yyrrrhmaai ciqarwkayr eskryqeqrk
     1141 kiillqstcr gfrarqrfka lkeqrlretk pevglvnikg ygsleiqgsd psgwedcsfd
     1201 nrikaieeck sviesnrisr essvdclkes pnkqqeraqs qsgvdlqedv lvrerprsle
     1261 dlhqkkvgra kresrrmrel eqaifslell kvrslggisp sedrrwstel vpeglqsprg
     1321 tpdsessqgs lellsyeesq ksklesvisd egdlqfpspk issspkfdsr dnalsasnet
     1381 ssaehlkdgt mkemvvcsse sitckpqlkd sfisnslptf fyipqqdplk tnsqldtsiq
     1441 rnkllenedt agealtldin retrryhcsg kdqivpslnt essnpvlkkl eklntekeer
     1501 qkqlqqqnek emmeqirqqt dilekerkaf ktiekprige clvapssyqs kqrverpssl
     1561 lslntsnkge lnvlgslslk daalaqkdss sahlppkdrp vtvfferkgs pcqsstvkel
     1621 sktdrmgtql nvacklsnnr iskrehfrpt qsyshnsddl sregnarpif ftpkdnmsip
     1681 lvskealnsk npqlhkedep awkpvklagp gqrevarpah kkkarmartr sdfltrgtfa
     1741 dgegdteedd yddiieplls ldqashcelg papslgqash sdsemtsqrf ssvdeqaklh
     1801 ktmsqgeitk lavrqkasds dirpqrakmr fwakgkqgek kttrvkpttq sevsplfagt
     1861 dvipahqfpd elaayhptpp lspelpgscr kefkenkeps pkakrkrsvk isnvaldsmh
     1921 wqndsvqiia svsdlksmde fllkkvndld nedskkdtlv dvvfkkalke frqnifsfys
     1981 salamddgks irykdlyalf eqilektmrl eqrdslgesp vrvwvntfkv fldeymnefk
     2041 tsdctatkvp kterkkrrkk etdlveehng hifkatqysi ptyceycssl iwimdrasvc
     2101 klckyachkk cclkttakcs kkydpelssr qfgvelsrlt sedrtvplvv eklinyiemh
     2161 glytegiyrk sgstnkikel rqgldtdaes vnlddynihv iasvfkqwlr dlpnplmtfe
     2221 lyeeflramg lqerketirg vysvidqlsr thlntlerli fhlvrialqe dtnrmsanal
     2281 aivfapcilr cpdttdplqs vqdisktttc velivveqmn kykarlkdis slefaenkak
     2341 trlslirrsm gkgrirrgny pgpsspvvvr lpsvsdvsee tltseaamet diteqqqaam
     2401 qqeervlteq ienlqkekee ltfemlvlep rasddetles easigtadss enlnmeseya
     2461 iseksersla lsslktagks epssklrkql kkqqdsldvv dssvsslcls ntasshgtrk
     2521 lfqiyskspf yraasgneal gmegplgqtk fledkpqfis rgtfnpekgk qklknvknsp
     2581 qktketpegt vmsgrrktvd pdctsnqqla lfgnnefmv
//
LOCUS       XP_011519921            2619 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-IXa isoform X5 [Homo sapiens].
ACCESSION   XP_011519921
VERSION     XP_011519921.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521619.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2619
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2619
                     /product="unconventional myosin-IXa isoform X5"
                     /calculated_mol_wt=300132
     Region          15..110
                     /region_name="RA_Myosin-IXa"
                     /note="Ras-associating (RA) domain found in Myosin-IXa;
                     cd17216"
                     /db_xref="CDD:340736"
     Region          160..985
                     /region_name="MYSc_Myo9"
                     /note="class IX myosin, motor domain; cd01385"
                     /db_xref="CDD:276836"
     Site            order(187..195,239..246,285..295,518..523)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276836"
     Site            187..195
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276836"
     Site            239..246
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276836"
     Site            285..295
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276836"
     Site            461
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:276836"
     Site            518..523
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276836"
     Site            order(547..558,561..570)
                     /site_type="active"
                     /note="relay loop [active]"
                     /db_xref="CDD:276836"
     Site            921..930
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276836"
     Site            order(933..960,964..985)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276836"
     Region          2048..2105
                     /region_name="C1_Myosin-IXa"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in unconventional myosin-IXa and similar proteins;
                     cd20883"
                     /db_xref="CDD:410433"
     Region          2114..2299
                     /region_name="RhoGAP_myosin_IX"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain present in class IX myosins. Class
                     IX myosins contain a characteristic head domain, a neck
                     domain, a tail domain which contains a C6H2-zinc binding
                     motif and a RhoGAP domain. Class...; cd04377"
                     /db_xref="CDD:239842"
     Site            order(2151,2188,2192,2261,2264..2265,2290)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239842"
     Site            2151
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239842"
     CDS             1..2619
                     /gene="MYO9A"
                     /gene_synonym="CMS24"
                     /coded_by="XM_011521619.4:543..8402"
                     /db_xref="GeneID:4649"
                     /db_xref="HGNC:HGNC:7608"
                     /db_xref="MIM:604875"
ORIGIN      
        1 mnindggrrr fednehtlri ypgaisegti ycpiparkns taaeviesli nklhldktkc
       61 yvlaevkefg geewilnptd cpvqrmmlwp rmalenrlsg edyrfllrek nldgsihygs
      121 lqswlrvtee rrrmmergfl pqpqqkdfdd lcslpdlnek tllenlrnrf khekiytyvg
      181 silivinpfk flpiynpkyv kmydnhqlgk lephiyavad vayhamlqrk knqcivisge
      241 sgsgktqstn flihhltals qkgfasgveq iilgagpvle afgnaktahn nnssrfgkfi
      301 qvnyqetgtv lgayvekyll eksrlvyqeh nernyhvfyy llagaseder safhlkqpee
      361 yhylnqdcft vegedlrhdf erlqlamemv gflpktrrqi fsllsailhl gnicykkkty
      421 rddsidicnp evlpivsell evkeemlfea lvtrktvtvg eklilpykla eavtvrnsma
      481 kslysalfdw ivfrinhall nskdlehntk tlsigvldif gfedyennsf eqfcinfane
      541 rlqhyfnqhi fkleqeeyrt egiswhnidy idntccinli skkptgllhl ldeesnfpqa
      601 tnqtlldkfk hqhednsyie fpavmepafi ikhyagkvky gvkdfreknt dhmrpdival
      661 lrssknafis gmigidpvav frwailraff ramvafreag krnihrktgh ddtapcailk
      721 smdsfsflqh pvhqrsleil qrckeekysi trknprtpls dlqgmnalne knqhdtfdia
      781 wngrtgirqs rlssgtslld kdgifansts skllerahgi ltrnknfksk palpkhllev
      841 nslkhltrlt lqdritksll hlhkkkkpps isaqfqasls klmetlgqae pyfvkcirsn
      901 aeklplrfsd vlvlrqlryt gmletvrirq sgysskysfq dfvshfhvll prniipskfn
      961 iqdffrkinl npdnyqvgkt mvflkeqerq hlqdllhqev lrriillqrw frvllcrqhf
     1021 lhlrqasvii qrfwrnylnq kqvrdaavqk dafvmasaaa llqaswrahl erqrylelra
     1081 aaiviqqkwr dyyrrrhmaa iciqarwkay reskryqeqr kkiillqstc rgfrarqrfk
     1141 alkeqrlret kpevglvnik gygsleiqgs dpsgwedcsf dnrikaieec ksviesnris
     1201 ressvdclke spnkqqeraq sqsgvdlqed vlvrerprsl edlhqkkvgr akresrrmre
     1261 leqaifslel lkvrslggis psedrrwste lvpeglqspr gtpdsessqg slellsyees
     1321 qksklesvis degdlqfpsp kissspkfds rdnalsasne tssaehlkdg tmkemvvcss
     1381 esitckpqlk dsfisnslpt ffyipqqdpl ktnsqldtsi qrnkllened tagealtldi
     1441 nretrryhcs gkdqivpsln tessnpvlkk leklntekee rqkqlqqqne kemmeqirqq
     1501 tdilekerka fktiekprig eclvapssyq skqrverpss llslntsnkg elnvlgslsl
     1561 kdaalaqkds ssahlppkdr pvtvfferkg spcqsstvke lsktdrmgtq lnvacklsnn
     1621 riskrehfrp tqsyshnsdd lsregnarpi fftpkdnmsi plvskealns knpqlhkede
     1681 pawkpvklag pgqreqvarp ahkkkarmar trsdfltrgt fadgegdtee ddyddiiepl
     1741 lsldqashce lgpapslgqa shsdsemtsq rfssvdeqak lhktmsqgei tklavrqkas
     1801 dsdirpqrak mrfwakgkqg ekkttrvkpt tqsevsplfa gtdvipahqf pdelaayhpt
     1861 pplspelpgs crkefkenke pspkakrkrs vkisnvalds mhwqndsvqi iasvsdlksm
     1921 defllkkvnd ldnedskkdt lvdvvfkkal kefrqnifsf yssalamddg ksirykdlya
     1981 lfeqilektm rleqrdslge spvrvwvntf kvfldeymne fktsdctatk vpkterkkrr
     2041 kketdlveeh nghifkatqy siptyceycs sliwimdras vcklckyach kkcclkttak
     2101 cskkydpels srqfgvelsr ltsedrtvpl vveklinyie mhglytegiy rksgstnkik
     2161 elrqgldtda esvnlddyni hviasvfkqw lrdlpnplmt felyeeflra mglqerketi
     2221 rgvysvidql srthlntler lifhlvrial qedtnrmsan alaivfapci lrcpdttdpl
     2281 qsvqdisktt tcvelivveq mnkykarlkd isslefaenk aktrlslirr smkpvliavr
     2341 fmnitrnsvs gkgrirrgny pgpsspvvvr lpsvsdvsee tltseaamet diteqqqaam
     2401 qqeervlteq ienlqkekee ltfemlvlep rasddetles easigtadss enlnmeseya
     2461 iseksersla lsslktagks epssklrkql kkqqdsldvv dssvsslcls ntasshgtrk
     2521 lfqiyskspf yraasgneal gmegplgqtk fledkpqfis rgtfnpekgk qklknvknsp
     2581 qktketpegt vmsgrrktvd pdctsnqqla lfgnnefmv
//
LOCUS       XP_047288507            2619 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-IXa isoform X5 [Homo sapiens].
ACCESSION   XP_047288507
VERSION     XP_047288507.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432551.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2619
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2619
                     /product="unconventional myosin-IXa isoform X5"
                     /calculated_mol_wt=300132
     Region          15..110
                     /region_name="RA_Myosin-IXa"
                     /note="Ras-associating (RA) domain found in Myosin-IXa;
                     cd17216"
                     /db_xref="CDD:340736"
     Region          160..985
                     /region_name="MYSc_Myo9"
                     /note="class IX myosin, motor domain; cd01385"
                     /db_xref="CDD:276836"
     Site            order(187..195,239..246,285..295,518..523)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276836"
     Site            187..195
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276836"
     Site            239..246
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276836"
     Site            285..295
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276836"
     Site            461
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:276836"
     Site            518..523
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276836"
     Site            order(547..558,561..570)
                     /site_type="active"
                     /note="relay loop [active]"
                     /db_xref="CDD:276836"
     Site            921..930
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276836"
     Site            order(933..960,964..985)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276836"
     Region          2048..2105
                     /region_name="C1_Myosin-IXa"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in unconventional myosin-IXa and similar proteins;
                     cd20883"
                     /db_xref="CDD:410433"
     Region          2114..2299
                     /region_name="RhoGAP_myosin_IX"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain present in class IX myosins. Class
                     IX myosins contain a characteristic head domain, a neck
                     domain, a tail domain which contains a C6H2-zinc binding
                     motif and a RhoGAP domain. Class...; cd04377"
                     /db_xref="CDD:239842"
     Site            order(2151,2188,2192,2261,2264..2265,2290)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239842"
     Site            2151
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239842"
     CDS             1..2619
                     /gene="MYO9A"
                     /gene_synonym="CMS24"
                     /coded_by="XM_047432551.1:140..7999"
                     /db_xref="GeneID:4649"
                     /db_xref="HGNC:HGNC:7608"
                     /db_xref="MIM:604875"
ORIGIN      
        1 mnindggrrr fednehtlri ypgaisegti ycpiparkns taaeviesli nklhldktkc
       61 yvlaevkefg geewilnptd cpvqrmmlwp rmalenrlsg edyrfllrek nldgsihygs
      121 lqswlrvtee rrrmmergfl pqpqqkdfdd lcslpdlnek tllenlrnrf khekiytyvg
      181 silivinpfk flpiynpkyv kmydnhqlgk lephiyavad vayhamlqrk knqcivisge
      241 sgsgktqstn flihhltals qkgfasgveq iilgagpvle afgnaktahn nnssrfgkfi
      301 qvnyqetgtv lgayvekyll eksrlvyqeh nernyhvfyy llagaseder safhlkqpee
      361 yhylnqdcft vegedlrhdf erlqlamemv gflpktrrqi fsllsailhl gnicykkkty
      421 rddsidicnp evlpivsell evkeemlfea lvtrktvtvg eklilpykla eavtvrnsma
      481 kslysalfdw ivfrinhall nskdlehntk tlsigvldif gfedyennsf eqfcinfane
      541 rlqhyfnqhi fkleqeeyrt egiswhnidy idntccinli skkptgllhl ldeesnfpqa
      601 tnqtlldkfk hqhednsyie fpavmepafi ikhyagkvky gvkdfreknt dhmrpdival
      661 lrssknafis gmigidpvav frwailraff ramvafreag krnihrktgh ddtapcailk
      721 smdsfsflqh pvhqrsleil qrckeekysi trknprtpls dlqgmnalne knqhdtfdia
      781 wngrtgirqs rlssgtslld kdgifansts skllerahgi ltrnknfksk palpkhllev
      841 nslkhltrlt lqdritksll hlhkkkkpps isaqfqasls klmetlgqae pyfvkcirsn
      901 aeklplrfsd vlvlrqlryt gmletvrirq sgysskysfq dfvshfhvll prniipskfn
      961 iqdffrkinl npdnyqvgkt mvflkeqerq hlqdllhqev lrriillqrw frvllcrqhf
     1021 lhlrqasvii qrfwrnylnq kqvrdaavqk dafvmasaaa llqaswrahl erqrylelra
     1081 aaiviqqkwr dyyrrrhmaa iciqarwkay reskryqeqr kkiillqstc rgfrarqrfk
     1141 alkeqrlret kpevglvnik gygsleiqgs dpsgwedcsf dnrikaieec ksviesnris
     1201 ressvdclke spnkqqeraq sqsgvdlqed vlvrerprsl edlhqkkvgr akresrrmre
     1261 leqaifslel lkvrslggis psedrrwste lvpeglqspr gtpdsessqg slellsyees
     1321 qksklesvis degdlqfpsp kissspkfds rdnalsasne tssaehlkdg tmkemvvcss
     1381 esitckpqlk dsfisnslpt ffyipqqdpl ktnsqldtsi qrnkllened tagealtldi
     1441 nretrryhcs gkdqivpsln tessnpvlkk leklntekee rqkqlqqqne kemmeqirqq
     1501 tdilekerka fktiekprig eclvapssyq skqrverpss llslntsnkg elnvlgslsl
     1561 kdaalaqkds ssahlppkdr pvtvfferkg spcqsstvke lsktdrmgtq lnvacklsnn
     1621 riskrehfrp tqsyshnsdd lsregnarpi fftpkdnmsi plvskealns knpqlhkede
     1681 pawkpvklag pgqreqvarp ahkkkarmar trsdfltrgt fadgegdtee ddyddiiepl
     1741 lsldqashce lgpapslgqa shsdsemtsq rfssvdeqak lhktmsqgei tklavrqkas
     1801 dsdirpqrak mrfwakgkqg ekkttrvkpt tqsevsplfa gtdvipahqf pdelaayhpt
     1861 pplspelpgs crkefkenke pspkakrkrs vkisnvalds mhwqndsvqi iasvsdlksm
     1921 defllkkvnd ldnedskkdt lvdvvfkkal kefrqnifsf yssalamddg ksirykdlya
     1981 lfeqilektm rleqrdslge spvrvwvntf kvfldeymne fktsdctatk vpkterkkrr
     2041 kketdlveeh nghifkatqy siptyceycs sliwimdras vcklckyach kkcclkttak
     2101 cskkydpels srqfgvelsr ltsedrtvpl vveklinyie mhglytegiy rksgstnkik
     2161 elrqgldtda esvnlddyni hviasvfkqw lrdlpnplmt felyeeflra mglqerketi
     2221 rgvysvidql srthlntler lifhlvrial qedtnrmsan alaivfapci lrcpdttdpl
     2281 qsvqdisktt tcvelivveq mnkykarlkd isslefaenk aktrlslirr smkpvliavr
     2341 fmnitrnsvs gkgrirrgny pgpsspvvvr lpsvsdvsee tltseaamet diteqqqaam
     2401 qqeervlteq ienlqkekee ltfemlvlep rasddetles easigtadss enlnmeseya
     2461 iseksersla lsslktagks epssklrkql kkqqdsldvv dssvsslcls ntasshgtrk
     2521 lfqiyskspf yraasgneal gmegplgqtk fledkpqfis rgtfnpekgk qklknvknsp
     2581 qktketpegt vmsgrrktvd pdctsnqqla lfgnnefmv
//
LOCUS       XP_047288508            2619 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-IXa isoform X5 [Homo sapiens].
ACCESSION   XP_047288508
VERSION     XP_047288508.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432552.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2619
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2619
                     /product="unconventional myosin-IXa isoform X5"
                     /calculated_mol_wt=300132
     Region          15..110
                     /region_name="RA_Myosin-IXa"
                     /note="Ras-associating (RA) domain found in Myosin-IXa;
                     cd17216"
                     /db_xref="CDD:340736"
     Region          160..985
                     /region_name="MYSc_Myo9"
                     /note="class IX myosin, motor domain; cd01385"
                     /db_xref="CDD:276836"
     Site            order(187..195,239..246,285..295,518..523)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276836"
     Site            187..195
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276836"
     Site            239..246
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276836"
     Site            285..295
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276836"
     Site            461
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:276836"
     Site            518..523
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276836"
     Site            order(547..558,561..570)
                     /site_type="active"
                     /note="relay loop [active]"
                     /db_xref="CDD:276836"
     Site            921..930
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276836"
     Site            order(933..960,964..985)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276836"
     Region          2048..2105
                     /region_name="C1_Myosin-IXa"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in unconventional myosin-IXa and similar proteins;
                     cd20883"
                     /db_xref="CDD:410433"
     Region          2114..2299
                     /region_name="RhoGAP_myosin_IX"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain present in class IX myosins. Class
                     IX myosins contain a characteristic head domain, a neck
                     domain, a tail domain which contains a C6H2-zinc binding
                     motif and a RhoGAP domain. Class...; cd04377"
                     /db_xref="CDD:239842"
     Site            order(2151,2188,2192,2261,2264..2265,2290)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239842"
     Site            2151
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239842"
     CDS             1..2619
                     /gene="MYO9A"
                     /gene_synonym="CMS24"
                     /coded_by="XM_047432552.1:588..8447"
                     /db_xref="GeneID:4649"
                     /db_xref="HGNC:HGNC:7608"
                     /db_xref="MIM:604875"
ORIGIN      
        1 mnindggrrr fednehtlri ypgaisegti ycpiparkns taaeviesli nklhldktkc
       61 yvlaevkefg geewilnptd cpvqrmmlwp rmalenrlsg edyrfllrek nldgsihygs
      121 lqswlrvtee rrrmmergfl pqpqqkdfdd lcslpdlnek tllenlrnrf khekiytyvg
      181 silivinpfk flpiynpkyv kmydnhqlgk lephiyavad vayhamlqrk knqcivisge
      241 sgsgktqstn flihhltals qkgfasgveq iilgagpvle afgnaktahn nnssrfgkfi
      301 qvnyqetgtv lgayvekyll eksrlvyqeh nernyhvfyy llagaseder safhlkqpee
      361 yhylnqdcft vegedlrhdf erlqlamemv gflpktrrqi fsllsailhl gnicykkkty
      421 rddsidicnp evlpivsell evkeemlfea lvtrktvtvg eklilpykla eavtvrnsma
      481 kslysalfdw ivfrinhall nskdlehntk tlsigvldif gfedyennsf eqfcinfane
      541 rlqhyfnqhi fkleqeeyrt egiswhnidy idntccinli skkptgllhl ldeesnfpqa
      601 tnqtlldkfk hqhednsyie fpavmepafi ikhyagkvky gvkdfreknt dhmrpdival
      661 lrssknafis gmigidpvav frwailraff ramvafreag krnihrktgh ddtapcailk
      721 smdsfsflqh pvhqrsleil qrckeekysi trknprtpls dlqgmnalne knqhdtfdia
      781 wngrtgirqs rlssgtslld kdgifansts skllerahgi ltrnknfksk palpkhllev
      841 nslkhltrlt lqdritksll hlhkkkkpps isaqfqasls klmetlgqae pyfvkcirsn
      901 aeklplrfsd vlvlrqlryt gmletvrirq sgysskysfq dfvshfhvll prniipskfn
      961 iqdffrkinl npdnyqvgkt mvflkeqerq hlqdllhqev lrriillqrw frvllcrqhf
     1021 lhlrqasvii qrfwrnylnq kqvrdaavqk dafvmasaaa llqaswrahl erqrylelra
     1081 aaiviqqkwr dyyrrrhmaa iciqarwkay reskryqeqr kkiillqstc rgfrarqrfk
     1141 alkeqrlret kpevglvnik gygsleiqgs dpsgwedcsf dnrikaieec ksviesnris
     1201 ressvdclke spnkqqeraq sqsgvdlqed vlvrerprsl edlhqkkvgr akresrrmre
     1261 leqaifslel lkvrslggis psedrrwste lvpeglqspr gtpdsessqg slellsyees
     1321 qksklesvis degdlqfpsp kissspkfds rdnalsasne tssaehlkdg tmkemvvcss
     1381 esitckpqlk dsfisnslpt ffyipqqdpl ktnsqldtsi qrnkllened tagealtldi
     1441 nretrryhcs gkdqivpsln tessnpvlkk leklntekee rqkqlqqqne kemmeqirqq
     1501 tdilekerka fktiekprig eclvapssyq skqrverpss llslntsnkg elnvlgslsl
     1561 kdaalaqkds ssahlppkdr pvtvfferkg spcqsstvke lsktdrmgtq lnvacklsnn
     1621 riskrehfrp tqsyshnsdd lsregnarpi fftpkdnmsi plvskealns knpqlhkede
     1681 pawkpvklag pgqreqvarp ahkkkarmar trsdfltrgt fadgegdtee ddyddiiepl
     1741 lsldqashce lgpapslgqa shsdsemtsq rfssvdeqak lhktmsqgei tklavrqkas
     1801 dsdirpqrak mrfwakgkqg ekkttrvkpt tqsevsplfa gtdvipahqf pdelaayhpt
     1861 pplspelpgs crkefkenke pspkakrkrs vkisnvalds mhwqndsvqi iasvsdlksm
     1921 defllkkvnd ldnedskkdt lvdvvfkkal kefrqnifsf yssalamddg ksirykdlya
     1981 lfeqilektm rleqrdslge spvrvwvntf kvfldeymne fktsdctatk vpkterkkrr
     2041 kketdlveeh nghifkatqy siptyceycs sliwimdras vcklckyach kkcclkttak
     2101 cskkydpels srqfgvelsr ltsedrtvpl vveklinyie mhglytegiy rksgstnkik
     2161 elrqgldtda esvnlddyni hviasvfkqw lrdlpnplmt felyeeflra mglqerketi
     2221 rgvysvidql srthlntler lifhlvrial qedtnrmsan alaivfapci lrcpdttdpl
     2281 qsvqdisktt tcvelivveq mnkykarlkd isslefaenk aktrlslirr smkpvliavr
     2341 fmnitrnsvs gkgrirrgny pgpsspvvvr lpsvsdvsee tltseaamet diteqqqaam
     2401 qqeervlteq ienlqkekee ltfemlvlep rasddetles easigtadss enlnmeseya
     2461 iseksersla lsslktagks epssklrkql kkqqdsldvv dssvsslcls ntasshgtrk
     2521 lfqiyskspf yraasgneal gmegplgqtk fledkpqfis rgtfnpekgk qklknvknsp
     2581 qktketpegt vmsgrrktvd pdctsnqqla lfgnnefmv
//
LOCUS       XP_047288509            2619 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-IXa isoform X5 [Homo sapiens].
ACCESSION   XP_047288509
VERSION     XP_047288509.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432553.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2619
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2619
                     /product="unconventional myosin-IXa isoform X5"
                     /calculated_mol_wt=300132
     Region          15..110
                     /region_name="RA_Myosin-IXa"
                     /note="Ras-associating (RA) domain found in Myosin-IXa;
                     cd17216"
                     /db_xref="CDD:340736"
     Region          160..985
                     /region_name="MYSc_Myo9"
                     /note="class IX myosin, motor domain; cd01385"
                     /db_xref="CDD:276836"
     Site            order(187..195,239..246,285..295,518..523)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276836"
     Site            187..195
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276836"
     Site            239..246
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276836"
     Site            285..295
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276836"
     Site            461
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:276836"
     Site            518..523
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276836"
     Site            order(547..558,561..570)
                     /site_type="active"
                     /note="relay loop [active]"
                     /db_xref="CDD:276836"
     Site            921..930
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276836"
     Site            order(933..960,964..985)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276836"
     Region          2048..2105
                     /region_name="C1_Myosin-IXa"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in unconventional myosin-IXa and similar proteins;
                     cd20883"
                     /db_xref="CDD:410433"
     Region          2114..2299
                     /region_name="RhoGAP_myosin_IX"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain present in class IX myosins. Class
                     IX myosins contain a characteristic head domain, a neck
                     domain, a tail domain which contains a C6H2-zinc binding
                     motif and a RhoGAP domain. Class...; cd04377"
                     /db_xref="CDD:239842"
     Site            order(2151,2188,2192,2261,2264..2265,2290)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239842"
     Site            2151
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239842"
     CDS             1..2619
                     /gene="MYO9A"
                     /gene_synonym="CMS24"
                     /coded_by="XM_047432553.1:362..8221"
                     /db_xref="GeneID:4649"
                     /db_xref="HGNC:HGNC:7608"
                     /db_xref="MIM:604875"
ORIGIN      
        1 mnindggrrr fednehtlri ypgaisegti ycpiparkns taaeviesli nklhldktkc
       61 yvlaevkefg geewilnptd cpvqrmmlwp rmalenrlsg edyrfllrek nldgsihygs
      121 lqswlrvtee rrrmmergfl pqpqqkdfdd lcslpdlnek tllenlrnrf khekiytyvg
      181 silivinpfk flpiynpkyv kmydnhqlgk lephiyavad vayhamlqrk knqcivisge
      241 sgsgktqstn flihhltals qkgfasgveq iilgagpvle afgnaktahn nnssrfgkfi
      301 qvnyqetgtv lgayvekyll eksrlvyqeh nernyhvfyy llagaseder safhlkqpee
      361 yhylnqdcft vegedlrhdf erlqlamemv gflpktrrqi fsllsailhl gnicykkkty
      421 rddsidicnp evlpivsell evkeemlfea lvtrktvtvg eklilpykla eavtvrnsma
      481 kslysalfdw ivfrinhall nskdlehntk tlsigvldif gfedyennsf eqfcinfane
      541 rlqhyfnqhi fkleqeeyrt egiswhnidy idntccinli skkptgllhl ldeesnfpqa
      601 tnqtlldkfk hqhednsyie fpavmepafi ikhyagkvky gvkdfreknt dhmrpdival
      661 lrssknafis gmigidpvav frwailraff ramvafreag krnihrktgh ddtapcailk
      721 smdsfsflqh pvhqrsleil qrckeekysi trknprtpls dlqgmnalne knqhdtfdia
      781 wngrtgirqs rlssgtslld kdgifansts skllerahgi ltrnknfksk palpkhllev
      841 nslkhltrlt lqdritksll hlhkkkkpps isaqfqasls klmetlgqae pyfvkcirsn
      901 aeklplrfsd vlvlrqlryt gmletvrirq sgysskysfq dfvshfhvll prniipskfn
      961 iqdffrkinl npdnyqvgkt mvflkeqerq hlqdllhqev lrriillqrw frvllcrqhf
     1021 lhlrqasvii qrfwrnylnq kqvrdaavqk dafvmasaaa llqaswrahl erqrylelra
     1081 aaiviqqkwr dyyrrrhmaa iciqarwkay reskryqeqr kkiillqstc rgfrarqrfk
     1141 alkeqrlret kpevglvnik gygsleiqgs dpsgwedcsf dnrikaieec ksviesnris
     1201 ressvdclke spnkqqeraq sqsgvdlqed vlvrerprsl edlhqkkvgr akresrrmre
     1261 leqaifslel lkvrslggis psedrrwste lvpeglqspr gtpdsessqg slellsyees
     1321 qksklesvis degdlqfpsp kissspkfds rdnalsasne tssaehlkdg tmkemvvcss
     1381 esitckpqlk dsfisnslpt ffyipqqdpl ktnsqldtsi qrnkllened tagealtldi
     1441 nretrryhcs gkdqivpsln tessnpvlkk leklntekee rqkqlqqqne kemmeqirqq
     1501 tdilekerka fktiekprig eclvapssyq skqrverpss llslntsnkg elnvlgslsl
     1561 kdaalaqkds ssahlppkdr pvtvfferkg spcqsstvke lsktdrmgtq lnvacklsnn
     1621 riskrehfrp tqsyshnsdd lsregnarpi fftpkdnmsi plvskealns knpqlhkede
     1681 pawkpvklag pgqreqvarp ahkkkarmar trsdfltrgt fadgegdtee ddyddiiepl
     1741 lsldqashce lgpapslgqa shsdsemtsq rfssvdeqak lhktmsqgei tklavrqkas
     1801 dsdirpqrak mrfwakgkqg ekkttrvkpt tqsevsplfa gtdvipahqf pdelaayhpt
     1861 pplspelpgs crkefkenke pspkakrkrs vkisnvalds mhwqndsvqi iasvsdlksm
     1921 defllkkvnd ldnedskkdt lvdvvfkkal kefrqnifsf yssalamddg ksirykdlya
     1981 lfeqilektm rleqrdslge spvrvwvntf kvfldeymne fktsdctatk vpkterkkrr
     2041 kketdlveeh nghifkatqy siptyceycs sliwimdras vcklckyach kkcclkttak
     2101 cskkydpels srqfgvelsr ltsedrtvpl vveklinyie mhglytegiy rksgstnkik
     2161 elrqgldtda esvnlddyni hviasvfkqw lrdlpnplmt felyeeflra mglqerketi
     2221 rgvysvidql srthlntler lifhlvrial qedtnrmsan alaivfapci lrcpdttdpl
     2281 qsvqdisktt tcvelivveq mnkykarlkd isslefaenk aktrlslirr smkpvliavr
     2341 fmnitrnsvs gkgrirrgny pgpsspvvvr lpsvsdvsee tltseaamet diteqqqaam
     2401 qqeervlteq ienlqkekee ltfemlvlep rasddetles easigtadss enlnmeseya
     2461 iseksersla lsslktagks epssklrkql kkqqdsldvv dssvsslcls ntasshgtrk
     2521 lfqiyskspf yraasgneal gmegplgqtk fledkpqfis rgtfnpekgk qklknvknsp
     2581 qktketpegt vmsgrrktvd pdctsnqqla lfgnnefmv
//
LOCUS       XP_011519922            2618 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-IXa isoform X6 [Homo sapiens].
ACCESSION   XP_011519922
VERSION     XP_011519922.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521620.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2618
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2618
                     /product="unconventional myosin-IXa isoform X6"
                     /calculated_mol_wt=300004
     Region          15..110
                     /region_name="RA_Myosin-IXa"
                     /note="Ras-associating (RA) domain found in Myosin-IXa;
                     cd17216"
                     /db_xref="CDD:340736"
     Region          160..985
                     /region_name="MYSc_Myo9"
                     /note="class IX myosin, motor domain; cd01385"
                     /db_xref="CDD:276836"
     Site            order(187..195,239..246,285..295,518..523)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276836"
     Site            187..195
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276836"
     Site            239..246
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276836"
     Site            285..295
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276836"
     Site            461
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:276836"
     Site            518..523
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276836"
     Site            order(547..558,561..570)
                     /site_type="active"
                     /note="relay loop [active]"
                     /db_xref="CDD:276836"
     Site            921..930
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276836"
     Site            order(933..960,964..985)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276836"
     Region          2047..2104
                     /region_name="C1_Myosin-IXa"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in unconventional myosin-IXa and similar proteins;
                     cd20883"
                     /db_xref="CDD:410433"
     Region          2113..2298
                     /region_name="RhoGAP_myosin_IX"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain present in class IX myosins. Class
                     IX myosins contain a characteristic head domain, a neck
                     domain, a tail domain which contains a C6H2-zinc binding
                     motif and a RhoGAP domain. Class...; cd04377"
                     /db_xref="CDD:239842"
     Site            order(2150,2187,2191,2260,2263..2264,2289)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239842"
     Site            2150
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239842"
     CDS             1..2618
                     /gene="MYO9A"
                     /gene_synonym="CMS24"
                     /coded_by="XM_011521620.4:543..8399"
                     /db_xref="GeneID:4649"
                     /db_xref="HGNC:HGNC:7608"
                     /db_xref="MIM:604875"
ORIGIN      
        1 mnindggrrr fednehtlri ypgaisegti ycpiparkns taaeviesli nklhldktkc
       61 yvlaevkefg geewilnptd cpvqrmmlwp rmalenrlsg edyrfllrek nldgsihygs
      121 lqswlrvtee rrrmmergfl pqpqqkdfdd lcslpdlnek tllenlrnrf khekiytyvg
      181 silivinpfk flpiynpkyv kmydnhqlgk lephiyavad vayhamlqrk knqcivisge
      241 sgsgktqstn flihhltals qkgfasgveq iilgagpvle afgnaktahn nnssrfgkfi
      301 qvnyqetgtv lgayvekyll eksrlvyqeh nernyhvfyy llagaseder safhlkqpee
      361 yhylnqdcft vegedlrhdf erlqlamemv gflpktrrqi fsllsailhl gnicykkkty
      421 rddsidicnp evlpivsell evkeemlfea lvtrktvtvg eklilpykla eavtvrnsma
      481 kslysalfdw ivfrinhall nskdlehntk tlsigvldif gfedyennsf eqfcinfane
      541 rlqhyfnqhi fkleqeeyrt egiswhnidy idntccinli skkptgllhl ldeesnfpqa
      601 tnqtlldkfk hqhednsyie fpavmepafi ikhyagkvky gvkdfreknt dhmrpdival
      661 lrssknafis gmigidpvav frwailraff ramvafreag krnihrktgh ddtapcailk
      721 smdsfsflqh pvhqrsleil qrckeekysi trknprtpls dlqgmnalne knqhdtfdia
      781 wngrtgirqs rlssgtslld kdgifansts skllerahgi ltrnknfksk palpkhllev
      841 nslkhltrlt lqdritksll hlhkkkkpps isaqfqasls klmetlgqae pyfvkcirsn
      901 aeklplrfsd vlvlrqlryt gmletvrirq sgysskysfq dfvshfhvll prniipskfn
      961 iqdffrkinl npdnyqvgkt mvflkeqerq hlqdllhqev lrriillqrw frvllcrqhf
     1021 lhlrqasvii qrfwrnylnq kqvrdaavqk dafvmasaaa llqaswrahl erqrylelra
     1081 aaiviqqkwr dyyrrrhmaa iciqarwkay reskryqeqr kkiillqstc rgfrarqrfk
     1141 alkeqrlret kpevglvnik gygsleiqgs dpsgwedcsf dnrikaieec ksviesnris
     1201 ressvdclke spnkqqeraq sqsgvdlqed vlvrerprsl edlhqkkvgr akresrrmre
     1261 leqaifslel lkvrslggis psedrrwste lvpeglqspr gtpdsessqg slellsyees
     1321 qksklesvis degdlqfpsp kissspkfds rdnalsasne tssaehlkdg tmkemvvcss
     1381 esitckpqlk dsfisnslpt ffyipqqdpl ktnsqldtsi qrnkllened tagealtldi
     1441 nretrryhcs gkdqivpsln tessnpvlkk leklntekee rqkqlqqqne kemmeqirqq
     1501 tdilekerka fktiekprig eclvapssyq skqrverpss llslntsnkg elnvlgslsl
     1561 kdaalaqkds ssahlppkdr pvtvfferkg spcqsstvke lsktdrmgtq lnvacklsnn
     1621 riskrehfrp tqsyshnsdd lsregnarpi fftpkdnmsi plvskealns knpqlhkede
     1681 pawkpvklag pgqrevarpa hkkkarmart rsdfltrgtf adgegdteed dyddiiepll
     1741 sldqashcel gpapslgqas hsdsemtsqr fssvdeqakl hktmsqgeit klavrqkasd
     1801 sdirpqrakm rfwakgkqge kkttrvkptt qsevsplfag tdvipahqfp delaayhptp
     1861 plspelpgsc rkefkenkep spkakrkrsv kisnvaldsm hwqndsvqii asvsdlksmd
     1921 efllkkvndl dnedskkdtl vdvvfkkalk efrqnifsfy ssalamddgk sirykdlyal
     1981 feqilektmr leqrdslges pvrvwvntfk vfldeymnef ktsdctatkv pkterkkrrk
     2041 ketdlveehn ghifkatqys iptyceycss liwimdrasv cklckyachk kcclkttakc
     2101 skkydpelss rqfgvelsrl tsedrtvplv veklinyiem hglytegiyr ksgstnkike
     2161 lrqgldtdae svnlddynih viasvfkqwl rdlpnplmtf elyeeflram glqerketir
     2221 gvysvidqls rthlntlerl ifhlvrialq edtnrmsana laivfapcil rcpdttdplq
     2281 svqdiskttt cvelivveqm nkykarlkdi sslefaenka ktrlslirrs mkpvliavrf
     2341 mnitrnsvsg kgrirrgnyp gpsspvvvrl psvsdvseet ltseaametd iteqqqaamq
     2401 qeervlteqi enlqkekeel tfemlvlepr asddetlese asigtadsse nlnmeseyai
     2461 sekserslal sslktagkse pssklrkqlk kqqdsldvvd ssvsslclsn tasshgtrkl
     2521 fqiyskspfy raasgnealg megplgqtkf ledkpqfisr gtfnpekgkq klknvknspq
     2581 ktketpegtv msgrrktvdp dctsnqqlal fgnnefmv
//
LOCUS       XP_047288510            2618 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-IXa isoform X6 [Homo sapiens].
ACCESSION   XP_047288510
VERSION     XP_047288510.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432554.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2618
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2618
                     /product="unconventional myosin-IXa isoform X6"
                     /calculated_mol_wt=300004
     Region          15..110
                     /region_name="RA_Myosin-IXa"
                     /note="Ras-associating (RA) domain found in Myosin-IXa;
                     cd17216"
                     /db_xref="CDD:340736"
     Region          160..985
                     /region_name="MYSc_Myo9"
                     /note="class IX myosin, motor domain; cd01385"
                     /db_xref="CDD:276836"
     Site            order(187..195,239..246,285..295,518..523)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276836"
     Site            187..195
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276836"
     Site            239..246
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276836"
     Site            285..295
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276836"
     Site            461
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:276836"
     Site            518..523
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276836"
     Site            order(547..558,561..570)
                     /site_type="active"
                     /note="relay loop [active]"
                     /db_xref="CDD:276836"
     Site            921..930
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276836"
     Site            order(933..960,964..985)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276836"
     Region          2047..2104
                     /region_name="C1_Myosin-IXa"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in unconventional myosin-IXa and similar proteins;
                     cd20883"
                     /db_xref="CDD:410433"
     Region          2113..2298
                     /region_name="RhoGAP_myosin_IX"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain present in class IX myosins. Class
                     IX myosins contain a characteristic head domain, a neck
                     domain, a tail domain which contains a C6H2-zinc binding
                     motif and a RhoGAP domain. Class...; cd04377"
                     /db_xref="CDD:239842"
     Site            order(2150,2187,2191,2260,2263..2264,2289)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239842"
     Site            2150
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239842"
     CDS             1..2618
                     /gene="MYO9A"
                     /gene_synonym="CMS24"
                     /coded_by="XM_047432554.1:140..7996"
                     /db_xref="GeneID:4649"
                     /db_xref="HGNC:HGNC:7608"
                     /db_xref="MIM:604875"
ORIGIN      
        1 mnindggrrr fednehtlri ypgaisegti ycpiparkns taaeviesli nklhldktkc
       61 yvlaevkefg geewilnptd cpvqrmmlwp rmalenrlsg edyrfllrek nldgsihygs
      121 lqswlrvtee rrrmmergfl pqpqqkdfdd lcslpdlnek tllenlrnrf khekiytyvg
      181 silivinpfk flpiynpkyv kmydnhqlgk lephiyavad vayhamlqrk knqcivisge
      241 sgsgktqstn flihhltals qkgfasgveq iilgagpvle afgnaktahn nnssrfgkfi
      301 qvnyqetgtv lgayvekyll eksrlvyqeh nernyhvfyy llagaseder safhlkqpee
      361 yhylnqdcft vegedlrhdf erlqlamemv gflpktrrqi fsllsailhl gnicykkkty
      421 rddsidicnp evlpivsell evkeemlfea lvtrktvtvg eklilpykla eavtvrnsma
      481 kslysalfdw ivfrinhall nskdlehntk tlsigvldif gfedyennsf eqfcinfane
      541 rlqhyfnqhi fkleqeeyrt egiswhnidy idntccinli skkptgllhl ldeesnfpqa
      601 tnqtlldkfk hqhednsyie fpavmepafi ikhyagkvky gvkdfreknt dhmrpdival
      661 lrssknafis gmigidpvav frwailraff ramvafreag krnihrktgh ddtapcailk
      721 smdsfsflqh pvhqrsleil qrckeekysi trknprtpls dlqgmnalne knqhdtfdia
      781 wngrtgirqs rlssgtslld kdgifansts skllerahgi ltrnknfksk palpkhllev
      841 nslkhltrlt lqdritksll hlhkkkkpps isaqfqasls klmetlgqae pyfvkcirsn
      901 aeklplrfsd vlvlrqlryt gmletvrirq sgysskysfq dfvshfhvll prniipskfn
      961 iqdffrkinl npdnyqvgkt mvflkeqerq hlqdllhqev lrriillqrw frvllcrqhf
     1021 lhlrqasvii qrfwrnylnq kqvrdaavqk dafvmasaaa llqaswrahl erqrylelra
     1081 aaiviqqkwr dyyrrrhmaa iciqarwkay reskryqeqr kkiillqstc rgfrarqrfk
     1141 alkeqrlret kpevglvnik gygsleiqgs dpsgwedcsf dnrikaieec ksviesnris
     1201 ressvdclke spnkqqeraq sqsgvdlqed vlvrerprsl edlhqkkvgr akresrrmre
     1261 leqaifslel lkvrslggis psedrrwste lvpeglqspr gtpdsessqg slellsyees
     1321 qksklesvis degdlqfpsp kissspkfds rdnalsasne tssaehlkdg tmkemvvcss
     1381 esitckpqlk dsfisnslpt ffyipqqdpl ktnsqldtsi qrnkllened tagealtldi
     1441 nretrryhcs gkdqivpsln tessnpvlkk leklntekee rqkqlqqqne kemmeqirqq
     1501 tdilekerka fktiekprig eclvapssyq skqrverpss llslntsnkg elnvlgslsl
     1561 kdaalaqkds ssahlppkdr pvtvfferkg spcqsstvke lsktdrmgtq lnvacklsnn
     1621 riskrehfrp tqsyshnsdd lsregnarpi fftpkdnmsi plvskealns knpqlhkede
     1681 pawkpvklag pgqrevarpa hkkkarmart rsdfltrgtf adgegdteed dyddiiepll
     1741 sldqashcel gpapslgqas hsdsemtsqr fssvdeqakl hktmsqgeit klavrqkasd
     1801 sdirpqrakm rfwakgkqge kkttrvkptt qsevsplfag tdvipahqfp delaayhptp
     1861 plspelpgsc rkefkenkep spkakrkrsv kisnvaldsm hwqndsvqii asvsdlksmd
     1921 efllkkvndl dnedskkdtl vdvvfkkalk efrqnifsfy ssalamddgk sirykdlyal
     1981 feqilektmr leqrdslges pvrvwvntfk vfldeymnef ktsdctatkv pkterkkrrk
     2041 ketdlveehn ghifkatqys iptyceycss liwimdrasv cklckyachk kcclkttakc
     2101 skkydpelss rqfgvelsrl tsedrtvplv veklinyiem hglytegiyr ksgstnkike
     2161 lrqgldtdae svnlddynih viasvfkqwl rdlpnplmtf elyeeflram glqerketir
     2221 gvysvidqls rthlntlerl ifhlvrialq edtnrmsana laivfapcil rcpdttdplq
     2281 svqdiskttt cvelivveqm nkykarlkdi sslefaenka ktrlslirrs mkpvliavrf
     2341 mnitrnsvsg kgrirrgnyp gpsspvvvrl psvsdvseet ltseaametd iteqqqaamq
     2401 qeervlteqi enlqkekeel tfemlvlepr asddetlese asigtadsse nlnmeseyai
     2461 sekserslal sslktagkse pssklrkqlk kqqdsldvvd ssvsslclsn tasshgtrkl
     2521 fqiyskspfy raasgnealg megplgqtkf ledkpqfisr gtfnpekgkq klknvknspq
     2581 ktketpegtv msgrrktvdp dctsnqqlal fgnnefmv
//
LOCUS       XP_047288511            2618 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-IXa isoform X6 [Homo sapiens].
ACCESSION   XP_047288511
VERSION     XP_047288511.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432555.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2618
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2618
                     /product="unconventional myosin-IXa isoform X6"
                     /calculated_mol_wt=300004
     Region          15..110
                     /region_name="RA_Myosin-IXa"
                     /note="Ras-associating (RA) domain found in Myosin-IXa;
                     cd17216"
                     /db_xref="CDD:340736"
     Region          160..985
                     /region_name="MYSc_Myo9"
                     /note="class IX myosin, motor domain; cd01385"
                     /db_xref="CDD:276836"
     Site            order(187..195,239..246,285..295,518..523)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276836"
     Site            187..195
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276836"
     Site            239..246
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276836"
     Site            285..295
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276836"
     Site            461
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:276836"
     Site            518..523
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276836"
     Site            order(547..558,561..570)
                     /site_type="active"
                     /note="relay loop [active]"
                     /db_xref="CDD:276836"
     Site            921..930
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276836"
     Site            order(933..960,964..985)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276836"
     Region          2047..2104
                     /region_name="C1_Myosin-IXa"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in unconventional myosin-IXa and similar proteins;
                     cd20883"
                     /db_xref="CDD:410433"
     Region          2113..2298
                     /region_name="RhoGAP_myosin_IX"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain present in class IX myosins. Class
                     IX myosins contain a characteristic head domain, a neck
                     domain, a tail domain which contains a C6H2-zinc binding
                     motif and a RhoGAP domain. Class...; cd04377"
                     /db_xref="CDD:239842"
     Site            order(2150,2187,2191,2260,2263..2264,2289)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239842"
     Site            2150
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239842"
     CDS             1..2618
                     /gene="MYO9A"
                     /gene_synonym="CMS24"
                     /coded_by="XM_047432555.1:588..8444"
                     /db_xref="GeneID:4649"
                     /db_xref="HGNC:HGNC:7608"
                     /db_xref="MIM:604875"
ORIGIN      
        1 mnindggrrr fednehtlri ypgaisegti ycpiparkns taaeviesli nklhldktkc
       61 yvlaevkefg geewilnptd cpvqrmmlwp rmalenrlsg edyrfllrek nldgsihygs
      121 lqswlrvtee rrrmmergfl pqpqqkdfdd lcslpdlnek tllenlrnrf khekiytyvg
      181 silivinpfk flpiynpkyv kmydnhqlgk lephiyavad vayhamlqrk knqcivisge
      241 sgsgktqstn flihhltals qkgfasgveq iilgagpvle afgnaktahn nnssrfgkfi
      301 qvnyqetgtv lgayvekyll eksrlvyqeh nernyhvfyy llagaseder safhlkqpee
      361 yhylnqdcft vegedlrhdf erlqlamemv gflpktrrqi fsllsailhl gnicykkkty
      421 rddsidicnp evlpivsell evkeemlfea lvtrktvtvg eklilpykla eavtvrnsma
      481 kslysalfdw ivfrinhall nskdlehntk tlsigvldif gfedyennsf eqfcinfane
      541 rlqhyfnqhi fkleqeeyrt egiswhnidy idntccinli skkptgllhl ldeesnfpqa
      601 tnqtlldkfk hqhednsyie fpavmepafi ikhyagkvky gvkdfreknt dhmrpdival
      661 lrssknafis gmigidpvav frwailraff ramvafreag krnihrktgh ddtapcailk
      721 smdsfsflqh pvhqrsleil qrckeekysi trknprtpls dlqgmnalne knqhdtfdia
      781 wngrtgirqs rlssgtslld kdgifansts skllerahgi ltrnknfksk palpkhllev
      841 nslkhltrlt lqdritksll hlhkkkkpps isaqfqasls klmetlgqae pyfvkcirsn
      901 aeklplrfsd vlvlrqlryt gmletvrirq sgysskysfq dfvshfhvll prniipskfn
      961 iqdffrkinl npdnyqvgkt mvflkeqerq hlqdllhqev lrriillqrw frvllcrqhf
     1021 lhlrqasvii qrfwrnylnq kqvrdaavqk dafvmasaaa llqaswrahl erqrylelra
     1081 aaiviqqkwr dyyrrrhmaa iciqarwkay reskryqeqr kkiillqstc rgfrarqrfk
     1141 alkeqrlret kpevglvnik gygsleiqgs dpsgwedcsf dnrikaieec ksviesnris
     1201 ressvdclke spnkqqeraq sqsgvdlqed vlvrerprsl edlhqkkvgr akresrrmre
     1261 leqaifslel lkvrslggis psedrrwste lvpeglqspr gtpdsessqg slellsyees
     1321 qksklesvis degdlqfpsp kissspkfds rdnalsasne tssaehlkdg tmkemvvcss
     1381 esitckpqlk dsfisnslpt ffyipqqdpl ktnsqldtsi qrnkllened tagealtldi
     1441 nretrryhcs gkdqivpsln tessnpvlkk leklntekee rqkqlqqqne kemmeqirqq
     1501 tdilekerka fktiekprig eclvapssyq skqrverpss llslntsnkg elnvlgslsl
     1561 kdaalaqkds ssahlppkdr pvtvfferkg spcqsstvke lsktdrmgtq lnvacklsnn
     1621 riskrehfrp tqsyshnsdd lsregnarpi fftpkdnmsi plvskealns knpqlhkede
     1681 pawkpvklag pgqrevarpa hkkkarmart rsdfltrgtf adgegdteed dyddiiepll
     1741 sldqashcel gpapslgqas hsdsemtsqr fssvdeqakl hktmsqgeit klavrqkasd
     1801 sdirpqrakm rfwakgkqge kkttrvkptt qsevsplfag tdvipahqfp delaayhptp
     1861 plspelpgsc rkefkenkep spkakrkrsv kisnvaldsm hwqndsvqii asvsdlksmd
     1921 efllkkvndl dnedskkdtl vdvvfkkalk efrqnifsfy ssalamddgk sirykdlyal
     1981 feqilektmr leqrdslges pvrvwvntfk vfldeymnef ktsdctatkv pkterkkrrk
     2041 ketdlveehn ghifkatqys iptyceycss liwimdrasv cklckyachk kcclkttakc
     2101 skkydpelss rqfgvelsrl tsedrtvplv veklinyiem hglytegiyr ksgstnkike
     2161 lrqgldtdae svnlddynih viasvfkqwl rdlpnplmtf elyeeflram glqerketir
     2221 gvysvidqls rthlntlerl ifhlvrialq edtnrmsana laivfapcil rcpdttdplq
     2281 svqdiskttt cvelivveqm nkykarlkdi sslefaenka ktrlslirrs mkpvliavrf
     2341 mnitrnsvsg kgrirrgnyp gpsspvvvrl psvsdvseet ltseaametd iteqqqaamq
     2401 qeervlteqi enlqkekeel tfemlvlepr asddetlese asigtadsse nlnmeseyai
     2461 sekserslal sslktagkse pssklrkqlk kqqdsldvvd ssvsslclsn tasshgtrkl
     2521 fqiyskspfy raasgnealg megplgqtkf ledkpqfisr gtfnpekgkq klknvknspq
     2581 ktketpegtv msgrrktvdp dctsnqqlal fgnnefmv
//
LOCUS       XP_047288512            2618 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-IXa isoform X6 [Homo sapiens].
ACCESSION   XP_047288512
VERSION     XP_047288512.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432556.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2618
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2618
                     /product="unconventional myosin-IXa isoform X6"
                     /calculated_mol_wt=300004
     Region          15..110
                     /region_name="RA_Myosin-IXa"
                     /note="Ras-associating (RA) domain found in Myosin-IXa;
                     cd17216"
                     /db_xref="CDD:340736"
     Region          160..985
                     /region_name="MYSc_Myo9"
                     /note="class IX myosin, motor domain; cd01385"
                     /db_xref="CDD:276836"
     Site            order(187..195,239..246,285..295,518..523)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276836"
     Site            187..195
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276836"
     Site            239..246
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276836"
     Site            285..295
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276836"
     Site            461
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:276836"
     Site            518..523
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276836"
     Site            order(547..558,561..570)
                     /site_type="active"
                     /note="relay loop [active]"
                     /db_xref="CDD:276836"
     Site            921..930
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276836"
     Site            order(933..960,964..985)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276836"
     Region          2047..2104
                     /region_name="C1_Myosin-IXa"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in unconventional myosin-IXa and similar proteins;
                     cd20883"
                     /db_xref="CDD:410433"
     Region          2113..2298
                     /region_name="RhoGAP_myosin_IX"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain present in class IX myosins. Class
                     IX myosins contain a characteristic head domain, a neck
                     domain, a tail domain which contains a C6H2-zinc binding
                     motif and a RhoGAP domain. Class...; cd04377"
                     /db_xref="CDD:239842"
     Site            order(2150,2187,2191,2260,2263..2264,2289)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239842"
     Site            2150
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239842"
     CDS             1..2618
                     /gene="MYO9A"
                     /gene_synonym="CMS24"
                     /coded_by="XM_047432556.1:346..8202"
                     /db_xref="GeneID:4649"
                     /db_xref="HGNC:HGNC:7608"
                     /db_xref="MIM:604875"
ORIGIN      
        1 mnindggrrr fednehtlri ypgaisegti ycpiparkns taaeviesli nklhldktkc
       61 yvlaevkefg geewilnptd cpvqrmmlwp rmalenrlsg edyrfllrek nldgsihygs
      121 lqswlrvtee rrrmmergfl pqpqqkdfdd lcslpdlnek tllenlrnrf khekiytyvg
      181 silivinpfk flpiynpkyv kmydnhqlgk lephiyavad vayhamlqrk knqcivisge
      241 sgsgktqstn flihhltals qkgfasgveq iilgagpvle afgnaktahn nnssrfgkfi
      301 qvnyqetgtv lgayvekyll eksrlvyqeh nernyhvfyy llagaseder safhlkqpee
      361 yhylnqdcft vegedlrhdf erlqlamemv gflpktrrqi fsllsailhl gnicykkkty
      421 rddsidicnp evlpivsell evkeemlfea lvtrktvtvg eklilpykla eavtvrnsma
      481 kslysalfdw ivfrinhall nskdlehntk tlsigvldif gfedyennsf eqfcinfane
      541 rlqhyfnqhi fkleqeeyrt egiswhnidy idntccinli skkptgllhl ldeesnfpqa
      601 tnqtlldkfk hqhednsyie fpavmepafi ikhyagkvky gvkdfreknt dhmrpdival
      661 lrssknafis gmigidpvav frwailraff ramvafreag krnihrktgh ddtapcailk
      721 smdsfsflqh pvhqrsleil qrckeekysi trknprtpls dlqgmnalne knqhdtfdia
      781 wngrtgirqs rlssgtslld kdgifansts skllerahgi ltrnknfksk palpkhllev
      841 nslkhltrlt lqdritksll hlhkkkkpps isaqfqasls klmetlgqae pyfvkcirsn
      901 aeklplrfsd vlvlrqlryt gmletvrirq sgysskysfq dfvshfhvll prniipskfn
      961 iqdffrkinl npdnyqvgkt mvflkeqerq hlqdllhqev lrriillqrw frvllcrqhf
     1021 lhlrqasvii qrfwrnylnq kqvrdaavqk dafvmasaaa llqaswrahl erqrylelra
     1081 aaiviqqkwr dyyrrrhmaa iciqarwkay reskryqeqr kkiillqstc rgfrarqrfk
     1141 alkeqrlret kpevglvnik gygsleiqgs dpsgwedcsf dnrikaieec ksviesnris
     1201 ressvdclke spnkqqeraq sqsgvdlqed vlvrerprsl edlhqkkvgr akresrrmre
     1261 leqaifslel lkvrslggis psedrrwste lvpeglqspr gtpdsessqg slellsyees
     1321 qksklesvis degdlqfpsp kissspkfds rdnalsasne tssaehlkdg tmkemvvcss
     1381 esitckpqlk dsfisnslpt ffyipqqdpl ktnsqldtsi qrnkllened tagealtldi
     1441 nretrryhcs gkdqivpsln tessnpvlkk leklntekee rqkqlqqqne kemmeqirqq
     1501 tdilekerka fktiekprig eclvapssyq skqrverpss llslntsnkg elnvlgslsl
     1561 kdaalaqkds ssahlppkdr pvtvfferkg spcqsstvke lsktdrmgtq lnvacklsnn
     1621 riskrehfrp tqsyshnsdd lsregnarpi fftpkdnmsi plvskealns knpqlhkede
     1681 pawkpvklag pgqrevarpa hkkkarmart rsdfltrgtf adgegdteed dyddiiepll
     1741 sldqashcel gpapslgqas hsdsemtsqr fssvdeqakl hktmsqgeit klavrqkasd
     1801 sdirpqrakm rfwakgkqge kkttrvkptt qsevsplfag tdvipahqfp delaayhptp
     1861 plspelpgsc rkefkenkep spkakrkrsv kisnvaldsm hwqndsvqii asvsdlksmd
     1921 efllkkvndl dnedskkdtl vdvvfkkalk efrqnifsfy ssalamddgk sirykdlyal
     1981 feqilektmr leqrdslges pvrvwvntfk vfldeymnef ktsdctatkv pkterkkrrk
     2041 ketdlveehn ghifkatqys iptyceycss liwimdrasv cklckyachk kcclkttakc
     2101 skkydpelss rqfgvelsrl tsedrtvplv veklinyiem hglytegiyr ksgstnkike
     2161 lrqgldtdae svnlddynih viasvfkqwl rdlpnplmtf elyeeflram glqerketir
     2221 gvysvidqls rthlntlerl ifhlvrialq edtnrmsana laivfapcil rcpdttdplq
     2281 svqdiskttt cvelivveqm nkykarlkdi sslefaenka ktrlslirrs mkpvliavrf
     2341 mnitrnsvsg kgrirrgnyp gpsspvvvrl psvsdvseet ltseaametd iteqqqaamq
     2401 qeervlteqi enlqkekeel tfemlvlepr asddetlese asigtadsse nlnmeseyai
     2461 sekserslal sslktagkse pssklrkqlk kqqdsldvvd ssvsslclsn tasshgtrkl
     2521 fqiyskspfy raasgnealg megplgqtkf ledkpqfisr gtfnpekgkq klknvknspq
     2581 ktketpegtv msgrrktvdp dctsnqqlal fgnnefmv
//
LOCUS       XP_047288513            2601 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-IXa isoform X7 [Homo sapiens].
ACCESSION   XP_047288513
VERSION     XP_047288513.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432557.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2601
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2601
                     /product="unconventional myosin-IXa isoform X7"
                     /calculated_mol_wt=298105
     Region          15..110
                     /region_name="RA_Myosin-IXa"
                     /note="Ras-associating (RA) domain found in Myosin-IXa;
                     cd17216"
                     /db_xref="CDD:340736"
     Region          160..985
                     /region_name="MYSc_Myo9"
                     /note="class IX myosin, motor domain; cd01385"
                     /db_xref="CDD:276836"
     Site            order(187..195,239..246,285..295,518..523)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276836"
     Site            187..195
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276836"
     Site            239..246
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276836"
     Site            285..295
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276836"
     Site            461
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:276836"
     Site            518..523
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276836"
     Site            order(547..558,561..570)
                     /site_type="active"
                     /note="relay loop [active]"
                     /db_xref="CDD:276836"
     Site            921..930
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276836"
     Site            order(933..960,964..985)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276836"
     Region          2048..2105
                     /region_name="C1_Myosin-IXa"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in unconventional myosin-IXa and similar proteins;
                     cd20883"
                     /db_xref="CDD:410433"
     Region          2114..2299
                     /region_name="RhoGAP_myosin_IX"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain present in class IX myosins. Class
                     IX myosins contain a characteristic head domain, a neck
                     domain, a tail domain which contains a C6H2-zinc binding
                     motif and a RhoGAP domain. Class...; cd04377"
                     /db_xref="CDD:239842"
     Site            order(2151,2188,2192,2261,2264..2265,2290)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239842"
     Site            2151
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239842"
     CDS             1..2601
                     /gene="MYO9A"
                     /gene_synonym="CMS24"
                     /coded_by="XM_047432557.1:543..8348"
                     /db_xref="GeneID:4649"
                     /db_xref="HGNC:HGNC:7608"
                     /db_xref="MIM:604875"
ORIGIN      
        1 mnindggrrr fednehtlri ypgaisegti ycpiparkns taaeviesli nklhldktkc
       61 yvlaevkefg geewilnptd cpvqrmmlwp rmalenrlsg edyrfllrek nldgsihygs
      121 lqswlrvtee rrrmmergfl pqpqqkdfdd lcslpdlnek tllenlrnrf khekiytyvg
      181 silivinpfk flpiynpkyv kmydnhqlgk lephiyavad vayhamlqrk knqcivisge
      241 sgsgktqstn flihhltals qkgfasgveq iilgagpvle afgnaktahn nnssrfgkfi
      301 qvnyqetgtv lgayvekyll eksrlvyqeh nernyhvfyy llagaseder safhlkqpee
      361 yhylnqdcft vegedlrhdf erlqlamemv gflpktrrqi fsllsailhl gnicykkkty
      421 rddsidicnp evlpivsell evkeemlfea lvtrktvtvg eklilpykla eavtvrnsma
      481 kslysalfdw ivfrinhall nskdlehntk tlsigvldif gfedyennsf eqfcinfane
      541 rlqhyfnqhi fkleqeeyrt egiswhnidy idntccinli skkptgllhl ldeesnfpqa
      601 tnqtlldkfk hqhednsyie fpavmepafi ikhyagkvky gvkdfreknt dhmrpdival
      661 lrssknafis gmigidpvav frwailraff ramvafreag krnihrktgh ddtapcailk
      721 smdsfsflqh pvhqrsleil qrckeekysi trknprtpls dlqgmnalne knqhdtfdia
      781 wngrtgirqs rlssgtslld kdgifansts skllerahgi ltrnknfksk palpkhllev
      841 nslkhltrlt lqdritksll hlhkkkkpps isaqfqasls klmetlgqae pyfvkcirsn
      901 aeklplrfsd vlvlrqlryt gmletvrirq sgysskysfq dfvshfhvll prniipskfn
      961 iqdffrkinl npdnyqvgkt mvflkeqerq hlqdllhqev lrriillqrw frvllcrqhf
     1021 lhlrqasvii qrfwrnylnq kqvrdaavqk dafvmasaaa llqaswrahl erqrylelra
     1081 aaiviqqkwr dyyrrrhmaa iciqarwkay reskryqeqr kkiillqstc rgfrarqrfk
     1141 alkeqrlret kpevglvnik gygsleiqgs dpsgwedcsf dnrikaieec ksviesnris
     1201 ressvdclke spnkqqeraq sqsgvdlqed vlvrerprsl edlhqkkvgr akresrrmre
     1261 leqaifslel lkvrslggis psedrrwste lvpeglqspr gtpdsessqg slellsyees
     1321 qksklesvis degdlqfpsp kissspkfds rdnalsasne tssaehlkdg tmkemvvcss
     1381 esitckpqlk dsfisnslpt ffyipqqdpl ktnsqldtsi qrnkllened tagealtldi
     1441 nretrryhcs gkdqivpsln tessnpvlkk leklntekee rqkqlqqqne kemmeqirqq
     1501 tdilekerka fktiekprig eclvapssyq skqrverpss llslntsnkg elnvlgslsl
     1561 kdaalaqkds ssahlppkdr pvtvfferkg spcqsstvke lsktdrmgtq lnvacklsnn
     1621 riskrehfrp tqsyshnsdd lsregnarpi fftpkdnmsi plvskealns knpqlhkede
     1681 pawkpvklag pgqreqvarp ahkkkarmar trsdfltrgt fadgegdtee ddyddiiepl
     1741 lsldqashce lgpapslgqa shsdsemtsq rfssvdeqak lhktmsqgei tklavrqkas
     1801 dsdirpqrak mrfwakgkqg ekkttrvkpt tqsevsplfa gtdvipahqf pdelaayhpt
     1861 pplspelpgs crkefkenke pspkakrkrs vkisnvalds mhwqndsvqi iasvsdlksm
     1921 defllkkvnd ldnedskkdt lvdvvfkkal kefrqnifsf yssalamddg ksirykdlya
     1981 lfeqilektm rleqrdslge spvrvwvntf kvfldeymne fktsdctatk vpkterkkrr
     2041 kketdlveeh nghifkatqy siptyceycs sliwimdras vcklckyach kkcclkttak
     2101 cskkydpels srqfgvelsr ltsedrtvpl vveklinyie mhglytegiy rksgstnkik
     2161 elrqgldtda esvnlddyni hviasvfkqw lrdlpnplmt felyeeflra mglqerketi
     2221 rgvysvidql srthlntler lifhlvrial qedtnrmsan alaivfapci lrcpdttdpl
     2281 qsvqdisktt tcvelivveq mnkykarlkd isslefaenk aktrlslirr smgkgrirrg
     2341 nypgpsspvv vrlpsvsdvs eetltseaam etditeqqqa amqqeervlt eqienlqkek
     2401 eeltfemlvl eprasddetl eseasigtad ssenlnmese yaiseksers lalsslktag
     2461 ksepssklrk qlkkqqdsld vvdssvsslc lsntasshgt rklfqiysks pfyraasgne
     2521 algmegplgq tkfledkpqf isrgtfnpek gkqklknvkn spqktketpe gtvmsgrrkt
     2581 vdpdctsnqq lalfgnnefm v
//
LOCUS       XP_047288514            2600 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-IXa isoform X8 [Homo sapiens].
ACCESSION   XP_047288514
VERSION     XP_047288514.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432558.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2600
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2600
                     /product="unconventional myosin-IXa isoform X8"
                     /calculated_mol_wt=297977
     Region          15..110
                     /region_name="RA_Myosin-IXa"
                     /note="Ras-associating (RA) domain found in Myosin-IXa;
                     cd17216"
                     /db_xref="CDD:340736"
     Region          160..985
                     /region_name="MYSc_Myo9"
                     /note="class IX myosin, motor domain; cd01385"
                     /db_xref="CDD:276836"
     Site            order(187..195,239..246,285..295,518..523)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276836"
     Site            187..195
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276836"
     Site            239..246
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276836"
     Site            285..295
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276836"
     Site            461
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:276836"
     Site            518..523
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276836"
     Site            order(547..558,561..570)
                     /site_type="active"
                     /note="relay loop [active]"
                     /db_xref="CDD:276836"
     Site            921..930
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276836"
     Site            order(933..960,964..985)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276836"
     Region          2047..2104
                     /region_name="C1_Myosin-IXa"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in unconventional myosin-IXa and similar proteins;
                     cd20883"
                     /db_xref="CDD:410433"
     Region          2113..2298
                     /region_name="RhoGAP_myosin_IX"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain present in class IX myosins. Class
                     IX myosins contain a characteristic head domain, a neck
                     domain, a tail domain which contains a C6H2-zinc binding
                     motif and a RhoGAP domain. Class...; cd04377"
                     /db_xref="CDD:239842"
     Site            order(2150,2187,2191,2260,2263..2264,2289)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239842"
     Site            2150
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239842"
     CDS             1..2600
                     /gene="MYO9A"
                     /gene_synonym="CMS24"
                     /coded_by="XM_047432558.1:543..8345"
                     /db_xref="GeneID:4649"
                     /db_xref="HGNC:HGNC:7608"
                     /db_xref="MIM:604875"
ORIGIN      
        1 mnindggrrr fednehtlri ypgaisegti ycpiparkns taaeviesli nklhldktkc
       61 yvlaevkefg geewilnptd cpvqrmmlwp rmalenrlsg edyrfllrek nldgsihygs
      121 lqswlrvtee rrrmmergfl pqpqqkdfdd lcslpdlnek tllenlrnrf khekiytyvg
      181 silivinpfk flpiynpkyv kmydnhqlgk lephiyavad vayhamlqrk knqcivisge
      241 sgsgktqstn flihhltals qkgfasgveq iilgagpvle afgnaktahn nnssrfgkfi
      301 qvnyqetgtv lgayvekyll eksrlvyqeh nernyhvfyy llagaseder safhlkqpee
      361 yhylnqdcft vegedlrhdf erlqlamemv gflpktrrqi fsllsailhl gnicykkkty
      421 rddsidicnp evlpivsell evkeemlfea lvtrktvtvg eklilpykla eavtvrnsma
      481 kslysalfdw ivfrinhall nskdlehntk tlsigvldif gfedyennsf eqfcinfane
      541 rlqhyfnqhi fkleqeeyrt egiswhnidy idntccinli skkptgllhl ldeesnfpqa
      601 tnqtlldkfk hqhednsyie fpavmepafi ikhyagkvky gvkdfreknt dhmrpdival
      661 lrssknafis gmigidpvav frwailraff ramvafreag krnihrktgh ddtapcailk
      721 smdsfsflqh pvhqrsleil qrckeekysi trknprtpls dlqgmnalne knqhdtfdia
      781 wngrtgirqs rlssgtslld kdgifansts skllerahgi ltrnknfksk palpkhllev
      841 nslkhltrlt lqdritksll hlhkkkkpps isaqfqasls klmetlgqae pyfvkcirsn
      901 aeklplrfsd vlvlrqlryt gmletvrirq sgysskysfq dfvshfhvll prniipskfn
      961 iqdffrkinl npdnyqvgkt mvflkeqerq hlqdllhqev lrriillqrw frvllcrqhf
     1021 lhlrqasvii qrfwrnylnq kqvrdaavqk dafvmasaaa llqaswrahl erqrylelra
     1081 aaiviqqkwr dyyrrrhmaa iciqarwkay reskryqeqr kkiillqstc rgfrarqrfk
     1141 alkeqrlret kpevglvnik gygsleiqgs dpsgwedcsf dnrikaieec ksviesnris
     1201 ressvdclke spnkqqeraq sqsgvdlqed vlvrerprsl edlhqkkvgr akresrrmre
     1261 leqaifslel lkvrslggis psedrrwste lvpeglqspr gtpdsessqg slellsyees
     1321 qksklesvis degdlqfpsp kissspkfds rdnalsasne tssaehlkdg tmkemvvcss
     1381 esitckpqlk dsfisnslpt ffyipqqdpl ktnsqldtsi qrnkllened tagealtldi
     1441 nretrryhcs gkdqivpsln tessnpvlkk leklntekee rqkqlqqqne kemmeqirqq
     1501 tdilekerka fktiekprig eclvapssyq skqrverpss llslntsnkg elnvlgslsl
     1561 kdaalaqkds ssahlppkdr pvtvfferkg spcqsstvke lsktdrmgtq lnvacklsnn
     1621 riskrehfrp tqsyshnsdd lsregnarpi fftpkdnmsi plvskealns knpqlhkede
     1681 pawkpvklag pgqrevarpa hkkkarmart rsdfltrgtf adgegdteed dyddiiepll
     1741 sldqashcel gpapslgqas hsdsemtsqr fssvdeqakl hktmsqgeit klavrqkasd
     1801 sdirpqrakm rfwakgkqge kkttrvkptt qsevsplfag tdvipahqfp delaayhptp
     1861 plspelpgsc rkefkenkep spkakrkrsv kisnvaldsm hwqndsvqii asvsdlksmd
     1921 efllkkvndl dnedskkdtl vdvvfkkalk efrqnifsfy ssalamddgk sirykdlyal
     1981 feqilektmr leqrdslges pvrvwvntfk vfldeymnef ktsdctatkv pkterkkrrk
     2041 ketdlveehn ghifkatqys iptyceycss liwimdrasv cklckyachk kcclkttakc
     2101 skkydpelss rqfgvelsrl tsedrtvplv veklinyiem hglytegiyr ksgstnkike
     2161 lrqgldtdae svnlddynih viasvfkqwl rdlpnplmtf elyeeflram glqerketir
     2221 gvysvidqls rthlntlerl ifhlvrialq edtnrmsana laivfapcil rcpdttdplq
     2281 svqdiskttt cvelivveqm nkykarlkdi sslefaenka ktrlslirrs mgkgrirrgn
     2341 ypgpsspvvv rlpsvsdvse etltseaame tditeqqqaa mqqeervlte qienlqkeke
     2401 eltfemlvle prasddetle seasigtads senlnmesey aiseksersl alsslktagk
     2461 sepssklrkq lkkqqdsldv vdssvsslcl sntasshgtr klfqiysksp fyraasgnea
     2521 lgmegplgqt kfledkpqfi srgtfnpekg kqklknvkns pqktketpeg tvmsgrrktv
     2581 dpdctsnqql alfgnnefmv
//
LOCUS       XP_047288515            2600 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-IXa isoform X8 [Homo sapiens].
ACCESSION   XP_047288515
VERSION     XP_047288515.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432559.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2600
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2600
                     /product="unconventional myosin-IXa isoform X8"
                     /calculated_mol_wt=297977
     Region          15..110
                     /region_name="RA_Myosin-IXa"
                     /note="Ras-associating (RA) domain found in Myosin-IXa;
                     cd17216"
                     /db_xref="CDD:340736"
     Region          160..985
                     /region_name="MYSc_Myo9"
                     /note="class IX myosin, motor domain; cd01385"
                     /db_xref="CDD:276836"
     Site            order(187..195,239..246,285..295,518..523)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276836"
     Site            187..195
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276836"
     Site            239..246
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276836"
     Site            285..295
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276836"
     Site            461
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:276836"
     Site            518..523
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276836"
     Site            order(547..558,561..570)
                     /site_type="active"
                     /note="relay loop [active]"
                     /db_xref="CDD:276836"
     Site            921..930
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276836"
     Site            order(933..960,964..985)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276836"
     Region          2047..2104
                     /region_name="C1_Myosin-IXa"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in unconventional myosin-IXa and similar proteins;
                     cd20883"
                     /db_xref="CDD:410433"
     Region          2113..2298
                     /region_name="RhoGAP_myosin_IX"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain present in class IX myosins. Class
                     IX myosins contain a characteristic head domain, a neck
                     domain, a tail domain which contains a C6H2-zinc binding
                     motif and a RhoGAP domain. Class...; cd04377"
                     /db_xref="CDD:239842"
     Site            order(2150,2187,2191,2260,2263..2264,2289)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239842"
     Site            2150
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239842"
     CDS             1..2600
                     /gene="MYO9A"
                     /gene_synonym="CMS24"
                     /coded_by="XM_047432559.1:140..7942"
                     /db_xref="GeneID:4649"
                     /db_xref="HGNC:HGNC:7608"
                     /db_xref="MIM:604875"
ORIGIN      
        1 mnindggrrr fednehtlri ypgaisegti ycpiparkns taaeviesli nklhldktkc
       61 yvlaevkefg geewilnptd cpvqrmmlwp rmalenrlsg edyrfllrek nldgsihygs
      121 lqswlrvtee rrrmmergfl pqpqqkdfdd lcslpdlnek tllenlrnrf khekiytyvg
      181 silivinpfk flpiynpkyv kmydnhqlgk lephiyavad vayhamlqrk knqcivisge
      241 sgsgktqstn flihhltals qkgfasgveq iilgagpvle afgnaktahn nnssrfgkfi
      301 qvnyqetgtv lgayvekyll eksrlvyqeh nernyhvfyy llagaseder safhlkqpee
      361 yhylnqdcft vegedlrhdf erlqlamemv gflpktrrqi fsllsailhl gnicykkkty
      421 rddsidicnp evlpivsell evkeemlfea lvtrktvtvg eklilpykla eavtvrnsma
      481 kslysalfdw ivfrinhall nskdlehntk tlsigvldif gfedyennsf eqfcinfane
      541 rlqhyfnqhi fkleqeeyrt egiswhnidy idntccinli skkptgllhl ldeesnfpqa
      601 tnqtlldkfk hqhednsyie fpavmepafi ikhyagkvky gvkdfreknt dhmrpdival
      661 lrssknafis gmigidpvav frwailraff ramvafreag krnihrktgh ddtapcailk
      721 smdsfsflqh pvhqrsleil qrckeekysi trknprtpls dlqgmnalne knqhdtfdia
      781 wngrtgirqs rlssgtslld kdgifansts skllerahgi ltrnknfksk palpkhllev
      841 nslkhltrlt lqdritksll hlhkkkkpps isaqfqasls klmetlgqae pyfvkcirsn
      901 aeklplrfsd vlvlrqlryt gmletvrirq sgysskysfq dfvshfhvll prniipskfn
      961 iqdffrkinl npdnyqvgkt mvflkeqerq hlqdllhqev lrriillqrw frvllcrqhf
     1021 lhlrqasvii qrfwrnylnq kqvrdaavqk dafvmasaaa llqaswrahl erqrylelra
     1081 aaiviqqkwr dyyrrrhmaa iciqarwkay reskryqeqr kkiillqstc rgfrarqrfk
     1141 alkeqrlret kpevglvnik gygsleiqgs dpsgwedcsf dnrikaieec ksviesnris
     1201 ressvdclke spnkqqeraq sqsgvdlqed vlvrerprsl edlhqkkvgr akresrrmre
     1261 leqaifslel lkvrslggis psedrrwste lvpeglqspr gtpdsessqg slellsyees
     1321 qksklesvis degdlqfpsp kissspkfds rdnalsasne tssaehlkdg tmkemvvcss
     1381 esitckpqlk dsfisnslpt ffyipqqdpl ktnsqldtsi qrnkllened tagealtldi
     1441 nretrryhcs gkdqivpsln tessnpvlkk leklntekee rqkqlqqqne kemmeqirqq
     1501 tdilekerka fktiekprig eclvapssyq skqrverpss llslntsnkg elnvlgslsl
     1561 kdaalaqkds ssahlppkdr pvtvfferkg spcqsstvke lsktdrmgtq lnvacklsnn
     1621 riskrehfrp tqsyshnsdd lsregnarpi fftpkdnmsi plvskealns knpqlhkede
     1681 pawkpvklag pgqrevarpa hkkkarmart rsdfltrgtf adgegdteed dyddiiepll
     1741 sldqashcel gpapslgqas hsdsemtsqr fssvdeqakl hktmsqgeit klavrqkasd
     1801 sdirpqrakm rfwakgkqge kkttrvkptt qsevsplfag tdvipahqfp delaayhptp
     1861 plspelpgsc rkefkenkep spkakrkrsv kisnvaldsm hwqndsvqii asvsdlksmd
     1921 efllkkvndl dnedskkdtl vdvvfkkalk efrqnifsfy ssalamddgk sirykdlyal
     1981 feqilektmr leqrdslges pvrvwvntfk vfldeymnef ktsdctatkv pkterkkrrk
     2041 ketdlveehn ghifkatqys iptyceycss liwimdrasv cklckyachk kcclkttakc
     2101 skkydpelss rqfgvelsrl tsedrtvplv veklinyiem hglytegiyr ksgstnkike
     2161 lrqgldtdae svnlddynih viasvfkqwl rdlpnplmtf elyeeflram glqerketir
     2221 gvysvidqls rthlntlerl ifhlvrialq edtnrmsana laivfapcil rcpdttdplq
     2281 svqdiskttt cvelivveqm nkykarlkdi sslefaenka ktrlslirrs mgkgrirrgn
     2341 ypgpsspvvv rlpsvsdvse etltseaame tditeqqqaa mqqeervlte qienlqkeke
     2401 eltfemlvle prasddetle seasigtads senlnmesey aiseksersl alsslktagk
     2461 sepssklrkq lkkqqdsldv vdssvsslcl sntasshgtr klfqiysksp fyraasgnea
     2521 lgmegplgqt kfledkpqfi srgtfnpekg kqklknvkns pqktketpeg tvmsgrrktv
     2581 dpdctsnqql alfgnnefmv
//
LOCUS       XP_047288516            2600 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-IXa isoform X8 [Homo sapiens].
ACCESSION   XP_047288516
VERSION     XP_047288516.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432560.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2600
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2600
                     /product="unconventional myosin-IXa isoform X8"
                     /calculated_mol_wt=297977
     Region          15..110
                     /region_name="RA_Myosin-IXa"
                     /note="Ras-associating (RA) domain found in Myosin-IXa;
                     cd17216"
                     /db_xref="CDD:340736"
     Region          160..985
                     /region_name="MYSc_Myo9"
                     /note="class IX myosin, motor domain; cd01385"
                     /db_xref="CDD:276836"
     Site            order(187..195,239..246,285..295,518..523)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276836"
     Site            187..195
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276836"
     Site            239..246
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276836"
     Site            285..295
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276836"
     Site            461
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:276836"
     Site            518..523
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276836"
     Site            order(547..558,561..570)
                     /site_type="active"
                     /note="relay loop [active]"
                     /db_xref="CDD:276836"
     Site            921..930
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276836"
     Site            order(933..960,964..985)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276836"
     Region          2047..2104
                     /region_name="C1_Myosin-IXa"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in unconventional myosin-IXa and similar proteins;
                     cd20883"
                     /db_xref="CDD:410433"
     Region          2113..2298
                     /region_name="RhoGAP_myosin_IX"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain present in class IX myosins. Class
                     IX myosins contain a characteristic head domain, a neck
                     domain, a tail domain which contains a C6H2-zinc binding
                     motif and a RhoGAP domain. Class...; cd04377"
                     /db_xref="CDD:239842"
     Site            order(2150,2187,2191,2260,2263..2264,2289)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239842"
     Site            2150
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239842"
     CDS             1..2600
                     /gene="MYO9A"
                     /gene_synonym="CMS24"
                     /coded_by="XM_047432560.1:588..8390"
                     /db_xref="GeneID:4649"
                     /db_xref="HGNC:HGNC:7608"
                     /db_xref="MIM:604875"
ORIGIN      
        1 mnindggrrr fednehtlri ypgaisegti ycpiparkns taaeviesli nklhldktkc
       61 yvlaevkefg geewilnptd cpvqrmmlwp rmalenrlsg edyrfllrek nldgsihygs
      121 lqswlrvtee rrrmmergfl pqpqqkdfdd lcslpdlnek tllenlrnrf khekiytyvg
      181 silivinpfk flpiynpkyv kmydnhqlgk lephiyavad vayhamlqrk knqcivisge
      241 sgsgktqstn flihhltals qkgfasgveq iilgagpvle afgnaktahn nnssrfgkfi
      301 qvnyqetgtv lgayvekyll eksrlvyqeh nernyhvfyy llagaseder safhlkqpee
      361 yhylnqdcft vegedlrhdf erlqlamemv gflpktrrqi fsllsailhl gnicykkkty
      421 rddsidicnp evlpivsell evkeemlfea lvtrktvtvg eklilpykla eavtvrnsma
      481 kslysalfdw ivfrinhall nskdlehntk tlsigvldif gfedyennsf eqfcinfane
      541 rlqhyfnqhi fkleqeeyrt egiswhnidy idntccinli skkptgllhl ldeesnfpqa
      601 tnqtlldkfk hqhednsyie fpavmepafi ikhyagkvky gvkdfreknt dhmrpdival
      661 lrssknafis gmigidpvav frwailraff ramvafreag krnihrktgh ddtapcailk
      721 smdsfsflqh pvhqrsleil qrckeekysi trknprtpls dlqgmnalne knqhdtfdia
      781 wngrtgirqs rlssgtslld kdgifansts skllerahgi ltrnknfksk palpkhllev
      841 nslkhltrlt lqdritksll hlhkkkkpps isaqfqasls klmetlgqae pyfvkcirsn
      901 aeklplrfsd vlvlrqlryt gmletvrirq sgysskysfq dfvshfhvll prniipskfn
      961 iqdffrkinl npdnyqvgkt mvflkeqerq hlqdllhqev lrriillqrw frvllcrqhf
     1021 lhlrqasvii qrfwrnylnq kqvrdaavqk dafvmasaaa llqaswrahl erqrylelra
     1081 aaiviqqkwr dyyrrrhmaa iciqarwkay reskryqeqr kkiillqstc rgfrarqrfk
     1141 alkeqrlret kpevglvnik gygsleiqgs dpsgwedcsf dnrikaieec ksviesnris
     1201 ressvdclke spnkqqeraq sqsgvdlqed vlvrerprsl edlhqkkvgr akresrrmre
     1261 leqaifslel lkvrslggis psedrrwste lvpeglqspr gtpdsessqg slellsyees
     1321 qksklesvis degdlqfpsp kissspkfds rdnalsasne tssaehlkdg tmkemvvcss
     1381 esitckpqlk dsfisnslpt ffyipqqdpl ktnsqldtsi qrnkllened tagealtldi
     1441 nretrryhcs gkdqivpsln tessnpvlkk leklntekee rqkqlqqqne kemmeqirqq
     1501 tdilekerka fktiekprig eclvapssyq skqrverpss llslntsnkg elnvlgslsl
     1561 kdaalaqkds ssahlppkdr pvtvfferkg spcqsstvke lsktdrmgtq lnvacklsnn
     1621 riskrehfrp tqsyshnsdd lsregnarpi fftpkdnmsi plvskealns knpqlhkede
     1681 pawkpvklag pgqrevarpa hkkkarmart rsdfltrgtf adgegdteed dyddiiepll
     1741 sldqashcel gpapslgqas hsdsemtsqr fssvdeqakl hktmsqgeit klavrqkasd
     1801 sdirpqrakm rfwakgkqge kkttrvkptt qsevsplfag tdvipahqfp delaayhptp
     1861 plspelpgsc rkefkenkep spkakrkrsv kisnvaldsm hwqndsvqii asvsdlksmd
     1921 efllkkvndl dnedskkdtl vdvvfkkalk efrqnifsfy ssalamddgk sirykdlyal
     1981 feqilektmr leqrdslges pvrvwvntfk vfldeymnef ktsdctatkv pkterkkrrk
     2041 ketdlveehn ghifkatqys iptyceycss liwimdrasv cklckyachk kcclkttakc
     2101 skkydpelss rqfgvelsrl tsedrtvplv veklinyiem hglytegiyr ksgstnkike
     2161 lrqgldtdae svnlddynih viasvfkqwl rdlpnplmtf elyeeflram glqerketir
     2221 gvysvidqls rthlntlerl ifhlvrialq edtnrmsana laivfapcil rcpdttdplq
     2281 svqdiskttt cvelivveqm nkykarlkdi sslefaenka ktrlslirrs mgkgrirrgn
     2341 ypgpsspvvv rlpsvsdvse etltseaame tditeqqqaa mqqeervlte qienlqkeke
     2401 eltfemlvle prasddetle seasigtads senlnmesey aiseksersl alsslktagk
     2461 sepssklrkq lkkqqdsldv vdssvsslcl sntasshgtr klfqiysksp fyraasgnea
     2521 lgmegplgqt kfledkpqfi srgtfnpekg kqklknvkns pqktketpeg tvmsgrrktv
     2581 dpdctsnqql alfgnnefmv
//
LOCUS       XP_011519923            2598 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-IXa isoform X9 [Homo sapiens].
ACCESSION   XP_011519923
VERSION     XP_011519923.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521621.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2598
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2598
                     /product="unconventional myosin-IXa isoform X9"
                     /calculated_mol_wt=297788
     Region          15..110
                     /region_name="RA_Myosin-IXa"
                     /note="Ras-associating (RA) domain found in Myosin-IXa;
                     cd17216"
                     /db_xref="CDD:340736"
     Region          160..964
                     /region_name="MYSc_Myo9"
                     /note="class IX myosin, motor domain; cd01385"
                     /db_xref="CDD:276836"
     Site            order(187..195,239..246,285..295,537..542)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276836"
     Site            187..195
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276836"
     Site            239..246
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276836"
     Site            285..295
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276836"
     Site            480
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:276836"
     Site            537..542
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276836"
     Site            order(566..577,580..589)
                     /site_type="active"
                     /note="relay loop [active]"
                     /db_xref="CDD:276836"
     Site            900..909
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276836"
     Site            order(912..939,943..964)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276836"
     Region          2027..2084
                     /region_name="C1_Myosin-IXa"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in unconventional myosin-IXa and similar proteins;
                     cd20883"
                     /db_xref="CDD:410433"
     Region          2093..2278
                     /region_name="RhoGAP_myosin_IX"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain present in class IX myosins. Class
                     IX myosins contain a characteristic head domain, a neck
                     domain, a tail domain which contains a C6H2-zinc binding
                     motif and a RhoGAP domain. Class...; cd04377"
                     /db_xref="CDD:239842"
     Site            order(2130,2167,2171,2240,2243..2244,2269)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239842"
     Site            2130
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239842"
     CDS             1..2598
                     /gene="MYO9A"
                     /gene_synonym="CMS24"
                     /coded_by="XM_011521621.4:543..8339"
                     /db_xref="GeneID:4649"
                     /db_xref="HGNC:HGNC:7608"
                     /db_xref="MIM:604875"
ORIGIN      
        1 mnindggrrr fednehtlri ypgaisegti ycpiparkns taaeviesli nklhldktkc
       61 yvlaevkefg geewilnptd cpvqrmmlwp rmalenrlsg edyrfllrek nldgsihygs
      121 lqswlrvtee rrrmmergfl pqpqqkdfdd lcslpdlnek tllenlrnrf khekiytyvg
      181 silivinpfk flpiynpkyv kmydnhqlgk lephiyavad vayhamlqrk knqcivisge
      241 sgsgktqstn flihhltals qkgfasgveq iilgagpvle afgnaktahn nnssrfgkfi
      301 qvnyqetgtv lgayvekyll eksrlvyqeh nernyhvfyy llagaseder safhlkqpee
      361 yhylnqitkk plrqswddyc ydsepdcftv egedlrhdfe rlqlamemvg flpktrrqif
      421 sllsailhlg nicykkktyr ddsidicnpe vlpivselle vkeemlfeal vtrktvtvge
      481 klilpyklae avtvrnsmak slysalfdwi vfrinhalln skdlehntkt lsigvldifg
      541 fedyennsfe qfcinfaner lqhyfnqhif kleqeeyrte giswhnidyi dntccinlis
      601 kkptgllhll deesnfpqat nqtlldkfkh qhednsyief pavmepafii khyagkvkyg
      661 vkdfrekntd hmrpdivall rssknafisg migidpvavf rwailraffr amvafreagk
      721 rnihrktgit rknprtplsd lqgmnalnek nqhdtfdiaw ngrtgirqsr lssgtslldk
      781 dgifanstss kllerahgil trnknfkskp alpkhllevn slkhltrltl qdritksllh
      841 lhkkkkppsi saqfqaslsk lmetlgqaep yfvkcirsna eklplrfsdv lvlrqlrytg
      901 mletvrirqs gysskysfqd fvshfhvllp rniipskfni qdffrkinln pdnyqvgktm
      961 vflkeqerqh lqdllhqevl rriillqrwf rvllcrqhfl hlrqasviiq rfwrnylnqk
     1021 qvrdaavqkd afvmasaaal lqaswrahle rqrylelraa aiviqqkwrd yyrrrhmaai
     1081 ciqarwkayr eskryqeqrk kiillqstcr gfrarqrfka lkeqrlretk pevglvnikg
     1141 ygsleiqgsd psgwedcsfd nrikaieeck sviesnrisr essvdclkes pnkqqeraqs
     1201 qsgvdlqedv lvrerprsle dlhqkkvgra kresrrmrel eqaifslell kvrslggisp
     1261 sedrrwstel vpeglqsprg tpdsessqgs lellsyeesq ksklesvisd egdlqfpspk
     1321 issspkfdsr dnalsasnet ssaehlkdgt mkemvvcsse sitckpqlkd sfisnslptf
     1381 fyipqqdplk tnsqldtsiq rnkllenedt agealtldin retrryhcsg kdqivpslnt
     1441 essnpvlkkl eklntekeer qkqlqqqnek emmeqirqqt dilekerkaf ktiekprige
     1501 clvapssyqs kqrverpssl lslntsnkge lnvlgslslk daalaqkdss sahlppkdrp
     1561 vtvfferkgs pcqsstvkel sktdrmgtql nvacklsnnr iskrehfrpt qsyshnsddl
     1621 sregnarpif ftpkdnmsip lvskealnsk npqlhkedep awkpvklagp gqreqvarpa
     1681 hkkkarmart rsdfltrgtf adgegdteed dyddiiepll sldqashcel gpapslgqas
     1741 hsdsemtsqr fssvdeqakl hktmsqgeit klavrqkasd sdirpqrakm rfwakgkqge
     1801 kkttrvkptt qsevsplfag tdvipahqfp delaayhptp plspelpgsc rkefkenkep
     1861 spkakrkrsv kisnvaldsm hwqndsvqii asvsdlksmd efllkkvndl dnedskkdtl
     1921 vdvvfkkalk efrqnifsfy ssalamddgk sirykdlyal feqilektmr leqrdslges
     1981 pvrvwvntfk vfldeymnef ktsdctatkv pkterkkrrk ketdlveehn ghifkatqys
     2041 iptyceycss liwimdrasv cklckyachk kcclkttakc skkydpelss rqfgvelsrl
     2101 tsedrtvplv veklinyiem hglytegiyr ksgstnkike lrqgldtdae svnlddynih
     2161 viasvfkqwl rdlpnplmtf elyeeflram glqerketir gvysvidqls rthlntlerl
     2221 ifhlvrialq edtnrmsana laivfapcil rcpdttdplq svqdiskttt cvelivveqm
     2281 nkykarlkdi sslefaenka ktrlslirrs mkpvliavrf mnitrnsvsg kgrirrgnyp
     2341 gpsspvvvrl psvsdvseet ltseaametd iteqqqaamq qeervlteqi enlqkekeel
     2401 tfemlvlepr asddetlese asigtadsse nlnmeseyai sekserslal sslktagkse
     2461 pssklrkqlk kqqdsldvvd ssvsslclsn tasshgtrkl fqiyskspfy raasgnealg
     2521 megplgqtkf ledkpqfisr gtfnpekgkq klknvknspq ktketpegtv msgrrktvdp
     2581 dctsnqqlal fgnnefmv
//
LOCUS       XP_047288517            2598 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-IXa isoform X9 [Homo sapiens].
ACCESSION   XP_047288517
VERSION     XP_047288517.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432561.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2598
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2598
                     /product="unconventional myosin-IXa isoform X9"
                     /calculated_mol_wt=297788
     Region          15..110
                     /region_name="RA_Myosin-IXa"
                     /note="Ras-associating (RA) domain found in Myosin-IXa;
                     cd17216"
                     /db_xref="CDD:340736"
     Region          160..964
                     /region_name="MYSc_Myo9"
                     /note="class IX myosin, motor domain; cd01385"
                     /db_xref="CDD:276836"
     Site            order(187..195,239..246,285..295,537..542)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276836"
     Site            187..195
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276836"
     Site            239..246
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276836"
     Site            285..295
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276836"
     Site            480
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:276836"
     Site            537..542
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276836"
     Site            order(566..577,580..589)
                     /site_type="active"
                     /note="relay loop [active]"
                     /db_xref="CDD:276836"
     Site            900..909
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276836"
     Site            order(912..939,943..964)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276836"
     Region          2027..2084
                     /region_name="C1_Myosin-IXa"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in unconventional myosin-IXa and similar proteins;
                     cd20883"
                     /db_xref="CDD:410433"
     Region          2093..2278
                     /region_name="RhoGAP_myosin_IX"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain present in class IX myosins. Class
                     IX myosins contain a characteristic head domain, a neck
                     domain, a tail domain which contains a C6H2-zinc binding
                     motif and a RhoGAP domain. Class...; cd04377"
                     /db_xref="CDD:239842"
     Site            order(2130,2167,2171,2240,2243..2244,2269)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239842"
     Site            2130
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239842"
     CDS             1..2598
                     /gene="MYO9A"
                     /gene_synonym="CMS24"
                     /coded_by="XM_047432561.1:140..7936"
                     /db_xref="GeneID:4649"
                     /db_xref="HGNC:HGNC:7608"
                     /db_xref="MIM:604875"
ORIGIN      
        1 mnindggrrr fednehtlri ypgaisegti ycpiparkns taaeviesli nklhldktkc
       61 yvlaevkefg geewilnptd cpvqrmmlwp rmalenrlsg edyrfllrek nldgsihygs
      121 lqswlrvtee rrrmmergfl pqpqqkdfdd lcslpdlnek tllenlrnrf khekiytyvg
      181 silivinpfk flpiynpkyv kmydnhqlgk lephiyavad vayhamlqrk knqcivisge
      241 sgsgktqstn flihhltals qkgfasgveq iilgagpvle afgnaktahn nnssrfgkfi
      301 qvnyqetgtv lgayvekyll eksrlvyqeh nernyhvfyy llagaseder safhlkqpee
      361 yhylnqitkk plrqswddyc ydsepdcftv egedlrhdfe rlqlamemvg flpktrrqif
      421 sllsailhlg nicykkktyr ddsidicnpe vlpivselle vkeemlfeal vtrktvtvge
      481 klilpyklae avtvrnsmak slysalfdwi vfrinhalln skdlehntkt lsigvldifg
      541 fedyennsfe qfcinfaner lqhyfnqhif kleqeeyrte giswhnidyi dntccinlis
      601 kkptgllhll deesnfpqat nqtlldkfkh qhednsyief pavmepafii khyagkvkyg
      661 vkdfrekntd hmrpdivall rssknafisg migidpvavf rwailraffr amvafreagk
      721 rnihrktgit rknprtplsd lqgmnalnek nqhdtfdiaw ngrtgirqsr lssgtslldk
      781 dgifanstss kllerahgil trnknfkskp alpkhllevn slkhltrltl qdritksllh
      841 lhkkkkppsi saqfqaslsk lmetlgqaep yfvkcirsna eklplrfsdv lvlrqlrytg
      901 mletvrirqs gysskysfqd fvshfhvllp rniipskfni qdffrkinln pdnyqvgktm
      961 vflkeqerqh lqdllhqevl rriillqrwf rvllcrqhfl hlrqasviiq rfwrnylnqk
     1021 qvrdaavqkd afvmasaaal lqaswrahle rqrylelraa aiviqqkwrd yyrrrhmaai
     1081 ciqarwkayr eskryqeqrk kiillqstcr gfrarqrfka lkeqrlretk pevglvnikg
     1141 ygsleiqgsd psgwedcsfd nrikaieeck sviesnrisr essvdclkes pnkqqeraqs
     1201 qsgvdlqedv lvrerprsle dlhqkkvgra kresrrmrel eqaifslell kvrslggisp
     1261 sedrrwstel vpeglqsprg tpdsessqgs lellsyeesq ksklesvisd egdlqfpspk
     1321 issspkfdsr dnalsasnet ssaehlkdgt mkemvvcsse sitckpqlkd sfisnslptf
     1381 fyipqqdplk tnsqldtsiq rnkllenedt agealtldin retrryhcsg kdqivpslnt
     1441 essnpvlkkl eklntekeer qkqlqqqnek emmeqirqqt dilekerkaf ktiekprige
     1501 clvapssyqs kqrverpssl lslntsnkge lnvlgslslk daalaqkdss sahlppkdrp
     1561 vtvfferkgs pcqsstvkel sktdrmgtql nvacklsnnr iskrehfrpt qsyshnsddl
     1621 sregnarpif ftpkdnmsip lvskealnsk npqlhkedep awkpvklagp gqreqvarpa
     1681 hkkkarmart rsdfltrgtf adgegdteed dyddiiepll sldqashcel gpapslgqas
     1741 hsdsemtsqr fssvdeqakl hktmsqgeit klavrqkasd sdirpqrakm rfwakgkqge
     1801 kkttrvkptt qsevsplfag tdvipahqfp delaayhptp plspelpgsc rkefkenkep
     1861 spkakrkrsv kisnvaldsm hwqndsvqii asvsdlksmd efllkkvndl dnedskkdtl
     1921 vdvvfkkalk efrqnifsfy ssalamddgk sirykdlyal feqilektmr leqrdslges
     1981 pvrvwvntfk vfldeymnef ktsdctatkv pkterkkrrk ketdlveehn ghifkatqys
     2041 iptyceycss liwimdrasv cklckyachk kcclkttakc skkydpelss rqfgvelsrl
     2101 tsedrtvplv veklinyiem hglytegiyr ksgstnkike lrqgldtdae svnlddynih
     2161 viasvfkqwl rdlpnplmtf elyeeflram glqerketir gvysvidqls rthlntlerl
     2221 ifhlvrialq edtnrmsana laivfapcil rcpdttdplq svqdiskttt cvelivveqm
     2281 nkykarlkdi sslefaenka ktrlslirrs mkpvliavrf mnitrnsvsg kgrirrgnyp
     2341 gpsspvvvrl psvsdvseet ltseaametd iteqqqaamq qeervlteqi enlqkekeel
     2401 tfemlvlepr asddetlese asigtadsse nlnmeseyai sekserslal sslktagkse
     2461 pssklrkqlk kqqdsldvvd ssvsslclsn tasshgtrkl fqiyskspfy raasgnealg
     2521 megplgqtkf ledkpqfisr gtfnpekgkq klknvknspq ktketpegtv msgrrktvdp
     2581 dctsnqqlal fgnnefmv
//
LOCUS       XP_047288518            2598 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-IXa isoform X9 [Homo sapiens].
ACCESSION   XP_047288518
VERSION     XP_047288518.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432562.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2598
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2598
                     /product="unconventional myosin-IXa isoform X9"
                     /calculated_mol_wt=297788
     Region          15..110
                     /region_name="RA_Myosin-IXa"
                     /note="Ras-associating (RA) domain found in Myosin-IXa;
                     cd17216"
                     /db_xref="CDD:340736"
     Region          160..964
                     /region_name="MYSc_Myo9"
                     /note="class IX myosin, motor domain; cd01385"
                     /db_xref="CDD:276836"
     Site            order(187..195,239..246,285..295,537..542)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276836"
     Site            187..195
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276836"
     Site            239..246
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276836"
     Site            285..295
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276836"
     Site            480
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:276836"
     Site            537..542
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276836"
     Site            order(566..577,580..589)
                     /site_type="active"
                     /note="relay loop [active]"
                     /db_xref="CDD:276836"
     Site            900..909
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276836"
     Site            order(912..939,943..964)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276836"
     Region          2027..2084
                     /region_name="C1_Myosin-IXa"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in unconventional myosin-IXa and similar proteins;
                     cd20883"
                     /db_xref="CDD:410433"
     Region          2093..2278
                     /region_name="RhoGAP_myosin_IX"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain present in class IX myosins. Class
                     IX myosins contain a characteristic head domain, a neck
                     domain, a tail domain which contains a C6H2-zinc binding
                     motif and a RhoGAP domain. Class...; cd04377"
                     /db_xref="CDD:239842"
     Site            order(2130,2167,2171,2240,2243..2244,2269)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239842"
     Site            2130
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239842"
     CDS             1..2598
                     /gene="MYO9A"
                     /gene_synonym="CMS24"
                     /coded_by="XM_047432562.1:588..8384"
                     /db_xref="GeneID:4649"
                     /db_xref="HGNC:HGNC:7608"
                     /db_xref="MIM:604875"
ORIGIN      
        1 mnindggrrr fednehtlri ypgaisegti ycpiparkns taaeviesli nklhldktkc
       61 yvlaevkefg geewilnptd cpvqrmmlwp rmalenrlsg edyrfllrek nldgsihygs
      121 lqswlrvtee rrrmmergfl pqpqqkdfdd lcslpdlnek tllenlrnrf khekiytyvg
      181 silivinpfk flpiynpkyv kmydnhqlgk lephiyavad vayhamlqrk knqcivisge
      241 sgsgktqstn flihhltals qkgfasgveq iilgagpvle afgnaktahn nnssrfgkfi
      301 qvnyqetgtv lgayvekyll eksrlvyqeh nernyhvfyy llagaseder safhlkqpee
      361 yhylnqitkk plrqswddyc ydsepdcftv egedlrhdfe rlqlamemvg flpktrrqif
      421 sllsailhlg nicykkktyr ddsidicnpe vlpivselle vkeemlfeal vtrktvtvge
      481 klilpyklae avtvrnsmak slysalfdwi vfrinhalln skdlehntkt lsigvldifg
      541 fedyennsfe qfcinfaner lqhyfnqhif kleqeeyrte giswhnidyi dntccinlis
      601 kkptgllhll deesnfpqat nqtlldkfkh qhednsyief pavmepafii khyagkvkyg
      661 vkdfrekntd hmrpdivall rssknafisg migidpvavf rwailraffr amvafreagk
      721 rnihrktgit rknprtplsd lqgmnalnek nqhdtfdiaw ngrtgirqsr lssgtslldk
      781 dgifanstss kllerahgil trnknfkskp alpkhllevn slkhltrltl qdritksllh
      841 lhkkkkppsi saqfqaslsk lmetlgqaep yfvkcirsna eklplrfsdv lvlrqlrytg
      901 mletvrirqs gysskysfqd fvshfhvllp rniipskfni qdffrkinln pdnyqvgktm
      961 vflkeqerqh lqdllhqevl rriillqrwf rvllcrqhfl hlrqasviiq rfwrnylnqk
     1021 qvrdaavqkd afvmasaaal lqaswrahle rqrylelraa aiviqqkwrd yyrrrhmaai
     1081 ciqarwkayr eskryqeqrk kiillqstcr gfrarqrfka lkeqrlretk pevglvnikg
     1141 ygsleiqgsd psgwedcsfd nrikaieeck sviesnrisr essvdclkes pnkqqeraqs
     1201 qsgvdlqedv lvrerprsle dlhqkkvgra kresrrmrel eqaifslell kvrslggisp
     1261 sedrrwstel vpeglqsprg tpdsessqgs lellsyeesq ksklesvisd egdlqfpspk
     1321 issspkfdsr dnalsasnet ssaehlkdgt mkemvvcsse sitckpqlkd sfisnslptf
     1381 fyipqqdplk tnsqldtsiq rnkllenedt agealtldin retrryhcsg kdqivpslnt
     1441 essnpvlkkl eklntekeer qkqlqqqnek emmeqirqqt dilekerkaf ktiekprige
     1501 clvapssyqs kqrverpssl lslntsnkge lnvlgslslk daalaqkdss sahlppkdrp
     1561 vtvfferkgs pcqsstvkel sktdrmgtql nvacklsnnr iskrehfrpt qsyshnsddl
     1621 sregnarpif ftpkdnmsip lvskealnsk npqlhkedep awkpvklagp gqreqvarpa
     1681 hkkkarmart rsdfltrgtf adgegdteed dyddiiepll sldqashcel gpapslgqas
     1741 hsdsemtsqr fssvdeqakl hktmsqgeit klavrqkasd sdirpqrakm rfwakgkqge
     1801 kkttrvkptt qsevsplfag tdvipahqfp delaayhptp plspelpgsc rkefkenkep
     1861 spkakrkrsv kisnvaldsm hwqndsvqii asvsdlksmd efllkkvndl dnedskkdtl
     1921 vdvvfkkalk efrqnifsfy ssalamddgk sirykdlyal feqilektmr leqrdslges
     1981 pvrvwvntfk vfldeymnef ktsdctatkv pkterkkrrk ketdlveehn ghifkatqys
     2041 iptyceycss liwimdrasv cklckyachk kcclkttakc skkydpelss rqfgvelsrl
     2101 tsedrtvplv veklinyiem hglytegiyr ksgstnkike lrqgldtdae svnlddynih
     2161 viasvfkqwl rdlpnplmtf elyeeflram glqerketir gvysvidqls rthlntlerl
     2221 ifhlvrialq edtnrmsana laivfapcil rcpdttdplq svqdiskttt cvelivveqm
     2281 nkykarlkdi sslefaenka ktrlslirrs mkpvliavrf mnitrnsvsg kgrirrgnyp
     2341 gpsspvvvrl psvsdvseet ltseaametd iteqqqaamq qeervlteqi enlqkekeel
     2401 tfemlvlepr asddetlese asigtadsse nlnmeseyai sekserslal sslktagkse
     2461 pssklrkqlk kqqdsldvvd ssvsslclsn tasshgtrkl fqiyskspfy raasgnealg
     2521 megplgqtkf ledkpqfisr gtfnpekgkq klknvknspq ktketpegtv msgrrktvdp
     2581 dctsnqqlal fgnnefmv
//
LOCUS       XP_047288520            2597 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-IXa isoform X10 [Homo sapiens].
ACCESSION   XP_047288520
VERSION     XP_047288520.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432564.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2597
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2597
                     /product="unconventional myosin-IXa isoform X10"
                     /calculated_mol_wt=297660
     Region          15..110
                     /region_name="RA_Myosin-IXa"
                     /note="Ras-associating (RA) domain found in Myosin-IXa;
                     cd17216"
                     /db_xref="CDD:340736"
     Region          160..964
                     /region_name="MYSc_Myo9"
                     /note="class IX myosin, motor domain; cd01385"
                     /db_xref="CDD:276836"
     Site            order(187..195,239..246,285..295,537..542)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276836"
     Site            187..195
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276836"
     Site            239..246
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276836"
     Site            285..295
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276836"
     Site            480
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:276836"
     Site            537..542
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276836"
     Site            order(566..577,580..589)
                     /site_type="active"
                     /note="relay loop [active]"
                     /db_xref="CDD:276836"
     Site            900..909
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276836"
     Site            order(912..939,943..964)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276836"
     Region          2026..2083
                     /region_name="C1_Myosin-IXa"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in unconventional myosin-IXa and similar proteins;
                     cd20883"
                     /db_xref="CDD:410433"
     Region          2092..2277
                     /region_name="RhoGAP_myosin_IX"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain present in class IX myosins. Class
                     IX myosins contain a characteristic head domain, a neck
                     domain, a tail domain which contains a C6H2-zinc binding
                     motif and a RhoGAP domain. Class...; cd04377"
                     /db_xref="CDD:239842"
     Site            order(2129,2166,2170,2239,2242..2243,2268)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239842"
     Site            2129
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239842"
     CDS             1..2597
                     /gene="MYO9A"
                     /gene_synonym="CMS24"
                     /coded_by="XM_047432564.1:543..8336"
                     /db_xref="GeneID:4649"
                     /db_xref="HGNC:HGNC:7608"
                     /db_xref="MIM:604875"
ORIGIN      
        1 mnindggrrr fednehtlri ypgaisegti ycpiparkns taaeviesli nklhldktkc
       61 yvlaevkefg geewilnptd cpvqrmmlwp rmalenrlsg edyrfllrek nldgsihygs
      121 lqswlrvtee rrrmmergfl pqpqqkdfdd lcslpdlnek tllenlrnrf khekiytyvg
      181 silivinpfk flpiynpkyv kmydnhqlgk lephiyavad vayhamlqrk knqcivisge
      241 sgsgktqstn flihhltals qkgfasgveq iilgagpvle afgnaktahn nnssrfgkfi
      301 qvnyqetgtv lgayvekyll eksrlvyqeh nernyhvfyy llagaseder safhlkqpee
      361 yhylnqitkk plrqswddyc ydsepdcftv egedlrhdfe rlqlamemvg flpktrrqif
      421 sllsailhlg nicykkktyr ddsidicnpe vlpivselle vkeemlfeal vtrktvtvge
      481 klilpyklae avtvrnsmak slysalfdwi vfrinhalln skdlehntkt lsigvldifg
      541 fedyennsfe qfcinfaner lqhyfnqhif kleqeeyrte giswhnidyi dntccinlis
      601 kkptgllhll deesnfpqat nqtlldkfkh qhednsyief pavmepafii khyagkvkyg
      661 vkdfrekntd hmrpdivall rssknafisg migidpvavf rwailraffr amvafreagk
      721 rnihrktgit rknprtplsd lqgmnalnek nqhdtfdiaw ngrtgirqsr lssgtslldk
      781 dgifanstss kllerahgil trnknfkskp alpkhllevn slkhltrltl qdritksllh
      841 lhkkkkppsi saqfqaslsk lmetlgqaep yfvkcirsna eklplrfsdv lvlrqlrytg
      901 mletvrirqs gysskysfqd fvshfhvllp rniipskfni qdffrkinln pdnyqvgktm
      961 vflkeqerqh lqdllhqevl rriillqrwf rvllcrqhfl hlrqasviiq rfwrnylnqk
     1021 qvrdaavqkd afvmasaaal lqaswrahle rqrylelraa aiviqqkwrd yyrrrhmaai
     1081 ciqarwkayr eskryqeqrk kiillqstcr gfrarqrfka lkeqrlretk pevglvnikg
     1141 ygsleiqgsd psgwedcsfd nrikaieeck sviesnrisr essvdclkes pnkqqeraqs
     1201 qsgvdlqedv lvrerprsle dlhqkkvgra kresrrmrel eqaifslell kvrslggisp
     1261 sedrrwstel vpeglqsprg tpdsessqgs lellsyeesq ksklesvisd egdlqfpspk
     1321 issspkfdsr dnalsasnet ssaehlkdgt mkemvvcsse sitckpqlkd sfisnslptf
     1381 fyipqqdplk tnsqldtsiq rnkllenedt agealtldin retrryhcsg kdqivpslnt
     1441 essnpvlkkl eklntekeer qkqlqqqnek emmeqirqqt dilekerkaf ktiekprige
     1501 clvapssyqs kqrverpssl lslntsnkge lnvlgslslk daalaqkdss sahlppkdrp
     1561 vtvfferkgs pcqsstvkel sktdrmgtql nvacklsnnr iskrehfrpt qsyshnsddl
     1621 sregnarpif ftpkdnmsip lvskealnsk npqlhkedep awkpvklagp gqrevarpah
     1681 kkkarmartr sdfltrgtfa dgegdteedd yddiieplls ldqashcelg papslgqash
     1741 sdsemtsqrf ssvdeqaklh ktmsqgeitk lavrqkasds dirpqrakmr fwakgkqgek
     1801 kttrvkpttq sevsplfagt dvipahqfpd elaayhptpp lspelpgscr kefkenkeps
     1861 pkakrkrsvk isnvaldsmh wqndsvqiia svsdlksmde fllkkvndld nedskkdtlv
     1921 dvvfkkalke frqnifsfys salamddgks irykdlyalf eqilektmrl eqrdslgesp
     1981 vrvwvntfkv fldeymnefk tsdctatkvp kterkkrrkk etdlveehng hifkatqysi
     2041 ptyceycssl iwimdrasvc klckyachkk cclkttakcs kkydpelssr qfgvelsrlt
     2101 sedrtvplvv eklinyiemh glytegiyrk sgstnkikel rqgldtdaes vnlddynihv
     2161 iasvfkqwlr dlpnplmtfe lyeeflramg lqerketirg vysvidqlsr thlntlerli
     2221 fhlvrialqe dtnrmsanal aivfapcilr cpdttdplqs vqdisktttc velivveqmn
     2281 kykarlkdis slefaenkak trlslirrsm kpvliavrfm nitrnsvsgk grirrgnypg
     2341 psspvvvrlp svsdvseetl tseaametdi teqqqaamqq eervlteqie nlqkekeelt
     2401 femlvlepra sddetlesea sigtadssen lnmeseyais ekserslals slktagksep
     2461 ssklrkqlkk qqdsldvvds svsslclsnt asshgtrklf qiyskspfyr aasgnealgm
     2521 egplgqtkfl edkpqfisrg tfnpekgkqk lknvknspqk tketpegtvm sgrrktvdpd
     2581 ctsnqqlalf gnnefmv
//
LOCUS       XP_047288521            2597 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-IXa isoform X10 [Homo sapiens].
ACCESSION   XP_047288521
VERSION     XP_047288521.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432565.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2597
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2597
                     /product="unconventional myosin-IXa isoform X10"
                     /calculated_mol_wt=297660
     Region          15..110
                     /region_name="RA_Myosin-IXa"
                     /note="Ras-associating (RA) domain found in Myosin-IXa;
                     cd17216"
                     /db_xref="CDD:340736"
     Region          160..964
                     /region_name="MYSc_Myo9"
                     /note="class IX myosin, motor domain; cd01385"
                     /db_xref="CDD:276836"
     Site            order(187..195,239..246,285..295,537..542)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276836"
     Site            187..195
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276836"
     Site            239..246
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276836"
     Site            285..295
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276836"
     Site            480
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:276836"
     Site            537..542
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276836"
     Site            order(566..577,580..589)
                     /site_type="active"
                     /note="relay loop [active]"
                     /db_xref="CDD:276836"
     Site            900..909
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276836"
     Site            order(912..939,943..964)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276836"
     Region          2026..2083
                     /region_name="C1_Myosin-IXa"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in unconventional myosin-IXa and similar proteins;
                     cd20883"
                     /db_xref="CDD:410433"
     Region          2092..2277
                     /region_name="RhoGAP_myosin_IX"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain present in class IX myosins. Class
                     IX myosins contain a characteristic head domain, a neck
                     domain, a tail domain which contains a C6H2-zinc binding
                     motif and a RhoGAP domain. Class...; cd04377"
                     /db_xref="CDD:239842"
     Site            order(2129,2166,2170,2239,2242..2243,2268)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239842"
     Site            2129
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239842"
     CDS             1..2597
                     /gene="MYO9A"
                     /gene_synonym="CMS24"
                     /coded_by="XM_047432565.1:140..7933"
                     /db_xref="GeneID:4649"
                     /db_xref="HGNC:HGNC:7608"
                     /db_xref="MIM:604875"
ORIGIN      
        1 mnindggrrr fednehtlri ypgaisegti ycpiparkns taaeviesli nklhldktkc
       61 yvlaevkefg geewilnptd cpvqrmmlwp rmalenrlsg edyrfllrek nldgsihygs
      121 lqswlrvtee rrrmmergfl pqpqqkdfdd lcslpdlnek tllenlrnrf khekiytyvg
      181 silivinpfk flpiynpkyv kmydnhqlgk lephiyavad vayhamlqrk knqcivisge
      241 sgsgktqstn flihhltals qkgfasgveq iilgagpvle afgnaktahn nnssrfgkfi
      301 qvnyqetgtv lgayvekyll eksrlvyqeh nernyhvfyy llagaseder safhlkqpee
      361 yhylnqitkk plrqswddyc ydsepdcftv egedlrhdfe rlqlamemvg flpktrrqif
      421 sllsailhlg nicykkktyr ddsidicnpe vlpivselle vkeemlfeal vtrktvtvge
      481 klilpyklae avtvrnsmak slysalfdwi vfrinhalln skdlehntkt lsigvldifg
      541 fedyennsfe qfcinfaner lqhyfnqhif kleqeeyrte giswhnidyi dntccinlis
      601 kkptgllhll deesnfpqat nqtlldkfkh qhednsyief pavmepafii khyagkvkyg
      661 vkdfrekntd hmrpdivall rssknafisg migidpvavf rwailraffr amvafreagk
      721 rnihrktgit rknprtplsd lqgmnalnek nqhdtfdiaw ngrtgirqsr lssgtslldk
      781 dgifanstss kllerahgil trnknfkskp alpkhllevn slkhltrltl qdritksllh
      841 lhkkkkppsi saqfqaslsk lmetlgqaep yfvkcirsna eklplrfsdv lvlrqlrytg
      901 mletvrirqs gysskysfqd fvshfhvllp rniipskfni qdffrkinln pdnyqvgktm
      961 vflkeqerqh lqdllhqevl rriillqrwf rvllcrqhfl hlrqasviiq rfwrnylnqk
     1021 qvrdaavqkd afvmasaaal lqaswrahle rqrylelraa aiviqqkwrd yyrrrhmaai
     1081 ciqarwkayr eskryqeqrk kiillqstcr gfrarqrfka lkeqrlretk pevglvnikg
     1141 ygsleiqgsd psgwedcsfd nrikaieeck sviesnrisr essvdclkes pnkqqeraqs
     1201 qsgvdlqedv lvrerprsle dlhqkkvgra kresrrmrel eqaifslell kvrslggisp
     1261 sedrrwstel vpeglqsprg tpdsessqgs lellsyeesq ksklesvisd egdlqfpspk
     1321 issspkfdsr dnalsasnet ssaehlkdgt mkemvvcsse sitckpqlkd sfisnslptf
     1381 fyipqqdplk tnsqldtsiq rnkllenedt agealtldin retrryhcsg kdqivpslnt
     1441 essnpvlkkl eklntekeer qkqlqqqnek emmeqirqqt dilekerkaf ktiekprige
     1501 clvapssyqs kqrverpssl lslntsnkge lnvlgslslk daalaqkdss sahlppkdrp
     1561 vtvfferkgs pcqsstvkel sktdrmgtql nvacklsnnr iskrehfrpt qsyshnsddl
     1621 sregnarpif ftpkdnmsip lvskealnsk npqlhkedep awkpvklagp gqrevarpah
     1681 kkkarmartr sdfltrgtfa dgegdteedd yddiieplls ldqashcelg papslgqash
     1741 sdsemtsqrf ssvdeqaklh ktmsqgeitk lavrqkasds dirpqrakmr fwakgkqgek
     1801 kttrvkpttq sevsplfagt dvipahqfpd elaayhptpp lspelpgscr kefkenkeps
     1861 pkakrkrsvk isnvaldsmh wqndsvqiia svsdlksmde fllkkvndld nedskkdtlv
     1921 dvvfkkalke frqnifsfys salamddgks irykdlyalf eqilektmrl eqrdslgesp
     1981 vrvwvntfkv fldeymnefk tsdctatkvp kterkkrrkk etdlveehng hifkatqysi
     2041 ptyceycssl iwimdrasvc klckyachkk cclkttakcs kkydpelssr qfgvelsrlt
     2101 sedrtvplvv eklinyiemh glytegiyrk sgstnkikel rqgldtdaes vnlddynihv
     2161 iasvfkqwlr dlpnplmtfe lyeeflramg lqerketirg vysvidqlsr thlntlerli
     2221 fhlvrialqe dtnrmsanal aivfapcilr cpdttdplqs vqdisktttc velivveqmn
     2281 kykarlkdis slefaenkak trlslirrsm kpvliavrfm nitrnsvsgk grirrgnypg
     2341 psspvvvrlp svsdvseetl tseaametdi teqqqaamqq eervlteqie nlqkekeelt
     2401 femlvlepra sddetlesea sigtadssen lnmeseyais ekserslals slktagksep
     2461 ssklrkqlkk qqdsldvvds svsslclsnt asshgtrklf qiyskspfyr aasgnealgm
     2521 egplgqtkfl edkpqfisrg tfnpekgkqk lknvknspqk tketpegtvm sgrrktvdpd
     2581 ctsnqqlalf gnnefmv
//
LOCUS       XP_047288522            2597 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-IXa isoform X10 [Homo sapiens].
ACCESSION   XP_047288522
VERSION     XP_047288522.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432566.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2597
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2597
                     /product="unconventional myosin-IXa isoform X10"
                     /calculated_mol_wt=297660
     Region          15..110
                     /region_name="RA_Myosin-IXa"
                     /note="Ras-associating (RA) domain found in Myosin-IXa;
                     cd17216"
                     /db_xref="CDD:340736"
     Region          160..964
                     /region_name="MYSc_Myo9"
                     /note="class IX myosin, motor domain; cd01385"
                     /db_xref="CDD:276836"
     Site            order(187..195,239..246,285..295,537..542)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276836"
     Site            187..195
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276836"
     Site            239..246
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276836"
     Site            285..295
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276836"
     Site            480
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:276836"
     Site            537..542
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276836"
     Site            order(566..577,580..589)
                     /site_type="active"
                     /note="relay loop [active]"
                     /db_xref="CDD:276836"
     Site            900..909
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276836"
     Site            order(912..939,943..964)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276836"
     Region          2026..2083
                     /region_name="C1_Myosin-IXa"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in unconventional myosin-IXa and similar proteins;
                     cd20883"
                     /db_xref="CDD:410433"
     Region          2092..2277
                     /region_name="RhoGAP_myosin_IX"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain present in class IX myosins. Class
                     IX myosins contain a characteristic head domain, a neck
                     domain, a tail domain which contains a C6H2-zinc binding
                     motif and a RhoGAP domain. Class...; cd04377"
                     /db_xref="CDD:239842"
     Site            order(2129,2166,2170,2239,2242..2243,2268)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239842"
     Site            2129
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239842"
     CDS             1..2597
                     /gene="MYO9A"
                     /gene_synonym="CMS24"
                     /coded_by="XM_047432566.1:588..8381"
                     /db_xref="GeneID:4649"
                     /db_xref="HGNC:HGNC:7608"
                     /db_xref="MIM:604875"
ORIGIN      
        1 mnindggrrr fednehtlri ypgaisegti ycpiparkns taaeviesli nklhldktkc
       61 yvlaevkefg geewilnptd cpvqrmmlwp rmalenrlsg edyrfllrek nldgsihygs
      121 lqswlrvtee rrrmmergfl pqpqqkdfdd lcslpdlnek tllenlrnrf khekiytyvg
      181 silivinpfk flpiynpkyv kmydnhqlgk lephiyavad vayhamlqrk knqcivisge
      241 sgsgktqstn flihhltals qkgfasgveq iilgagpvle afgnaktahn nnssrfgkfi
      301 qvnyqetgtv lgayvekyll eksrlvyqeh nernyhvfyy llagaseder safhlkqpee
      361 yhylnqitkk plrqswddyc ydsepdcftv egedlrhdfe rlqlamemvg flpktrrqif
      421 sllsailhlg nicykkktyr ddsidicnpe vlpivselle vkeemlfeal vtrktvtvge
      481 klilpyklae avtvrnsmak slysalfdwi vfrinhalln skdlehntkt lsigvldifg
      541 fedyennsfe qfcinfaner lqhyfnqhif kleqeeyrte giswhnidyi dntccinlis
      601 kkptgllhll deesnfpqat nqtlldkfkh qhednsyief pavmepafii khyagkvkyg
      661 vkdfrekntd hmrpdivall rssknafisg migidpvavf rwailraffr amvafreagk
      721 rnihrktgit rknprtplsd lqgmnalnek nqhdtfdiaw ngrtgirqsr lssgtslldk
      781 dgifanstss kllerahgil trnknfkskp alpkhllevn slkhltrltl qdritksllh
      841 lhkkkkppsi saqfqaslsk lmetlgqaep yfvkcirsna eklplrfsdv lvlrqlrytg
      901 mletvrirqs gysskysfqd fvshfhvllp rniipskfni qdffrkinln pdnyqvgktm
      961 vflkeqerqh lqdllhqevl rriillqrwf rvllcrqhfl hlrqasviiq rfwrnylnqk
     1021 qvrdaavqkd afvmasaaal lqaswrahle rqrylelraa aiviqqkwrd yyrrrhmaai
     1081 ciqarwkayr eskryqeqrk kiillqstcr gfrarqrfka lkeqrlretk pevglvnikg
     1141 ygsleiqgsd psgwedcsfd nrikaieeck sviesnrisr essvdclkes pnkqqeraqs
     1201 qsgvdlqedv lvrerprsle dlhqkkvgra kresrrmrel eqaifslell kvrslggisp
     1261 sedrrwstel vpeglqsprg tpdsessqgs lellsyeesq ksklesvisd egdlqfpspk
     1321 issspkfdsr dnalsasnet ssaehlkdgt mkemvvcsse sitckpqlkd sfisnslptf
     1381 fyipqqdplk tnsqldtsiq rnkllenedt agealtldin retrryhcsg kdqivpslnt
     1441 essnpvlkkl eklntekeer qkqlqqqnek emmeqirqqt dilekerkaf ktiekprige
     1501 clvapssyqs kqrverpssl lslntsnkge lnvlgslslk daalaqkdss sahlppkdrp
     1561 vtvfferkgs pcqsstvkel sktdrmgtql nvacklsnnr iskrehfrpt qsyshnsddl
     1621 sregnarpif ftpkdnmsip lvskealnsk npqlhkedep awkpvklagp gqrevarpah
     1681 kkkarmartr sdfltrgtfa dgegdteedd yddiieplls ldqashcelg papslgqash
     1741 sdsemtsqrf ssvdeqaklh ktmsqgeitk lavrqkasds dirpqrakmr fwakgkqgek
     1801 kttrvkpttq sevsplfagt dvipahqfpd elaayhptpp lspelpgscr kefkenkeps
     1861 pkakrkrsvk isnvaldsmh wqndsvqiia svsdlksmde fllkkvndld nedskkdtlv
     1921 dvvfkkalke frqnifsfys salamddgks irykdlyalf eqilektmrl eqrdslgesp
     1981 vrvwvntfkv fldeymnefk tsdctatkvp kterkkrrkk etdlveehng hifkatqysi
     2041 ptyceycssl iwimdrasvc klckyachkk cclkttakcs kkydpelssr qfgvelsrlt
     2101 sedrtvplvv eklinyiemh glytegiyrk sgstnkikel rqgldtdaes vnlddynihv
     2161 iasvfkqwlr dlpnplmtfe lyeeflramg lqerketirg vysvidqlsr thlntlerli
     2221 fhlvrialqe dtnrmsanal aivfapcilr cpdttdplqs vqdisktttc velivveqmn
     2281 kykarlkdis slefaenkak trlslirrsm kpvliavrfm nitrnsvsgk grirrgnypg
     2341 psspvvvrlp svsdvseetl tseaametdi teqqqaamqq eervlteqie nlqkekeelt
     2401 femlvlepra sddetlesea sigtadssen lnmeseyais ekserslals slktagksep
     2461 ssklrkqlkk qqdsldvvds svsslclsnt asshgtrklf qiyskspfyr aasgnealgm
     2521 egplgqtkfl edkpqfisrg tfnpekgkqk lknvknspqk tketpegtvm sgrrktvdpd
     2581 ctsnqqlalf gnnefmv
//
LOCUS       XP_047288523            2579 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-IXa isoform X11 [Homo sapiens].
ACCESSION   XP_047288523
VERSION     XP_047288523.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432567.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2579
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2579
                     /product="unconventional myosin-IXa isoform X11"
                     /calculated_mol_wt=295632
     Region          15..110
                     /region_name="RA_Myosin-IXa"
                     /note="Ras-associating (RA) domain found in Myosin-IXa;
                     cd17216"
                     /db_xref="CDD:340736"
     Region          160..964
                     /region_name="MYSc_Myo9"
                     /note="class IX myosin, motor domain; cd01385"
                     /db_xref="CDD:276836"
     Site            order(187..195,239..246,285..295,537..542)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276836"
     Site            187..195
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276836"
     Site            239..246
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276836"
     Site            285..295
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276836"
     Site            480
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:276836"
     Site            537..542
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276836"
     Site            order(566..577,580..589)
                     /site_type="active"
                     /note="relay loop [active]"
                     /db_xref="CDD:276836"
     Site            900..909
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276836"
     Site            order(912..939,943..964)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276836"
     Region          2026..2083
                     /region_name="C1_Myosin-IXa"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in unconventional myosin-IXa and similar proteins;
                     cd20883"
                     /db_xref="CDD:410433"
     Region          2092..2277
                     /region_name="RhoGAP_myosin_IX"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain present in class IX myosins. Class
                     IX myosins contain a characteristic head domain, a neck
                     domain, a tail domain which contains a C6H2-zinc binding
                     motif and a RhoGAP domain. Class...; cd04377"
                     /db_xref="CDD:239842"
     Site            order(2129,2166,2170,2239,2242..2243,2268)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239842"
     Site            2129
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239842"
     CDS             1..2579
                     /gene="MYO9A"
                     /gene_synonym="CMS24"
                     /coded_by="XM_047432567.1:543..8282"
                     /db_xref="GeneID:4649"
                     /db_xref="HGNC:HGNC:7608"
                     /db_xref="MIM:604875"
ORIGIN      
        1 mnindggrrr fednehtlri ypgaisegti ycpiparkns taaeviesli nklhldktkc
       61 yvlaevkefg geewilnptd cpvqrmmlwp rmalenrlsg edyrfllrek nldgsihygs
      121 lqswlrvtee rrrmmergfl pqpqqkdfdd lcslpdlnek tllenlrnrf khekiytyvg
      181 silivinpfk flpiynpkyv kmydnhqlgk lephiyavad vayhamlqrk knqcivisge
      241 sgsgktqstn flihhltals qkgfasgveq iilgagpvle afgnaktahn nnssrfgkfi
      301 qvnyqetgtv lgayvekyll eksrlvyqeh nernyhvfyy llagaseder safhlkqpee
      361 yhylnqitkk plrqswddyc ydsepdcftv egedlrhdfe rlqlamemvg flpktrrqif
      421 sllsailhlg nicykkktyr ddsidicnpe vlpivselle vkeemlfeal vtrktvtvge
      481 klilpyklae avtvrnsmak slysalfdwi vfrinhalln skdlehntkt lsigvldifg
      541 fedyennsfe qfcinfaner lqhyfnqhif kleqeeyrte giswhnidyi dntccinlis
      601 kkptgllhll deesnfpqat nqtlldkfkh qhednsyief pavmepafii khyagkvkyg
      661 vkdfrekntd hmrpdivall rssknafisg migidpvavf rwailraffr amvafreagk
      721 rnihrktgit rknprtplsd lqgmnalnek nqhdtfdiaw ngrtgirqsr lssgtslldk
      781 dgifanstss kllerahgil trnknfkskp alpkhllevn slkhltrltl qdritksllh
      841 lhkkkkppsi saqfqaslsk lmetlgqaep yfvkcirsna eklplrfsdv lvlrqlrytg
      901 mletvrirqs gysskysfqd fvshfhvllp rniipskfni qdffrkinln pdnyqvgktm
      961 vflkeqerqh lqdllhqevl rriillqrwf rvllcrqhfl hlrqasviiq rfwrnylnqk
     1021 qvrdaavqkd afvmasaaal lqaswrahle rqrylelraa aiviqqkwrd yyrrrhmaai
     1081 ciqarwkayr eskryqeqrk kiillqstcr gfrarqrfka lkeqrlretk pevglvnikg
     1141 ygsleiqgsd psgwedcsfd nrikaieeck sviesnrisr essvdclkes pnkqqeraqs
     1201 qsgvdlqedv lvrerprsle dlhqkkvgra kresrrmrel eqaifslell kvrslggisp
     1261 sedrrwstel vpeglqsprg tpdsessqgs lellsyeesq ksklesvisd egdlqfpspk
     1321 issspkfdsr dnalsasnet ssaehlkdgt mkemvvcsse sitckpqlkd sfisnslptf
     1381 fyipqqdplk tnsqldtsiq rnkllenedt agealtldin retrryhcsg kdqivpslnt
     1441 essnpvlkkl eklntekeer qkqlqqqnek emmeqirqqt dilekerkaf ktiekprige
     1501 clvapssyqs kqrverpssl lslntsnkge lnvlgslslk daalaqkdss sahlppkdrp
     1561 vtvfferkgs pcqsstvkel sktdrmgtql nvacklsnnr iskrehfrpt qsyshnsddl
     1621 sregnarpif ftpkdnmsip lvskealnsk npqlhkedep awkpvklagp gqrevarpah
     1681 kkkarmartr sdfltrgtfa dgegdteedd yddiieplls ldqashcelg papslgqash
     1741 sdsemtsqrf ssvdeqaklh ktmsqgeitk lavrqkasds dirpqrakmr fwakgkqgek
     1801 kttrvkpttq sevsplfagt dvipahqfpd elaayhptpp lspelpgscr kefkenkeps
     1861 pkakrkrsvk isnvaldsmh wqndsvqiia svsdlksmde fllkkvndld nedskkdtlv
     1921 dvvfkkalke frqnifsfys salamddgks irykdlyalf eqilektmrl eqrdslgesp
     1981 vrvwvntfkv fldeymnefk tsdctatkvp kterkkrrkk etdlveehng hifkatqysi
     2041 ptyceycssl iwimdrasvc klckyachkk cclkttakcs kkydpelssr qfgvelsrlt
     2101 sedrtvplvv eklinyiemh glytegiyrk sgstnkikel rqgldtdaes vnlddynihv
     2161 iasvfkqwlr dlpnplmtfe lyeeflramg lqerketirg vysvidqlsr thlntlerli
     2221 fhlvrialqe dtnrmsanal aivfapcilr cpdttdplqs vqdisktttc velivveqmn
     2281 kykarlkdis slefaenkak trlslirrsm gkgrirrgny pgpsspvvvr lpsvsdvsee
     2341 tltseaamet diteqqqaam qqeervlteq ienlqkekee ltfemlvlep rasddetles
     2401 easigtadss enlnmeseya iseksersla lsslktagks epssklrkql kkqqdsldvv
     2461 dssvsslcls ntasshgtrk lfqiyskspf yraasgneal gmegplgqtk fledkpqfis
     2521 rgtfnpekgk qklknvknsp qktketpegt vmsgrrktvd pdctsnqqla lfgnnefmv
//
LOCUS       XP_047288524            2579 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-IXa isoform X12 [Homo sapiens].
ACCESSION   XP_047288524
VERSION     XP_047288524.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432568.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2579
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2579
                     /product="unconventional myosin-IXa isoform X12"
                     /calculated_mol_wt=295461
     Region          15..110
                     /region_name="RA_Myosin-IXa"
                     /note="Ras-associating (RA) domain found in Myosin-IXa;
                     cd17216"
                     /db_xref="CDD:340736"
     Region          160..945
                     /region_name="MYSc_Myo9"
                     /note="class IX myosin, motor domain; cd01385"
                     /db_xref="CDD:276836"
     Site            order(187..195,239..246,285..295,518..523)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276836"
     Site            187..195
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276836"
     Site            239..246
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276836"
     Site            285..295
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276836"
     Site            461
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:276836"
     Site            518..523
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276836"
     Site            order(547..558,561..570)
                     /site_type="active"
                     /note="relay loop [active]"
                     /db_xref="CDD:276836"
     Site            881..890
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276836"
     Site            order(893..920,924..945)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276836"
     Region          2008..2065
                     /region_name="C1_Myosin-IXa"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in unconventional myosin-IXa and similar proteins;
                     cd20883"
                     /db_xref="CDD:410433"
     Region          2074..2259
                     /region_name="RhoGAP_myosin_IX"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain present in class IX myosins. Class
                     IX myosins contain a characteristic head domain, a neck
                     domain, a tail domain which contains a C6H2-zinc binding
                     motif and a RhoGAP domain. Class...; cd04377"
                     /db_xref="CDD:239842"
     Site            order(2111,2148,2152,2221,2224..2225,2250)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239842"
     Site            2111
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239842"
     CDS             1..2579
                     /gene="MYO9A"
                     /gene_synonym="CMS24"
                     /coded_by="XM_047432568.1:543..8282"
                     /db_xref="GeneID:4649"
                     /db_xref="HGNC:HGNC:7608"
                     /db_xref="MIM:604875"
ORIGIN      
        1 mnindggrrr fednehtlri ypgaisegti ycpiparkns taaeviesli nklhldktkc
       61 yvlaevkefg geewilnptd cpvqrmmlwp rmalenrlsg edyrfllrek nldgsihygs
      121 lqswlrvtee rrrmmergfl pqpqqkdfdd lcslpdlnek tllenlrnrf khekiytyvg
      181 silivinpfk flpiynpkyv kmydnhqlgk lephiyavad vayhamlqrk knqcivisge
      241 sgsgktqstn flihhltals qkgfasgveq iilgagpvle afgnaktahn nnssrfgkfi
      301 qvnyqetgtv lgayvekyll eksrlvyqeh nernyhvfyy llagaseder safhlkqpee
      361 yhylnqdcft vegedlrhdf erlqlamemv gflpktrrqi fsllsailhl gnicykkkty
      421 rddsidicnp evlpivsell evkeemlfea lvtrktvtvg eklilpykla eavtvrnsma
      481 kslysalfdw ivfrinhall nskdlehntk tlsigvldif gfedyennsf eqfcinfane
      541 rlqhyfnqhi fkleqeeyrt egiswhnidy idntccinli skkptgllhl ldeesnfpqa
      601 tnqtlldkfk hqhednsyie fpavmepafi ikhyagkvky gvkdfreknt dhmrpdival
      661 lrssknafis gmigidpvav frwailraff ramvafreag krnihrktgi trknprtpls
      721 dlqgmnalne knqhdtfdia wngrtgirqs rlssgtslld kdgifansts skllerahgi
      781 ltrnknfksk palpkhllev nslkhltrlt lqdritksll hlhkkkkpps isaqfqasls
      841 klmetlgqae pyfvkcirsn aeklplrfsd vlvlrqlryt gmletvrirq sgysskysfq
      901 dfvshfhvll prniipskfn iqdffrkinl npdnyqvgkt mvflkeqerq hlqdllhqev
      961 lrriillqrw frvllcrqhf lhlrqasvii qrfwrnylnq kqvrdaavqk dafvmasaaa
     1021 llqaswrahl erqrylelra aaiviqqkwr dyyrrrhmaa iciqarwkay reskryqeqr
     1081 kkiillqstc rgfrarqrfk alkeqrlret kpevglvnik gygsleiqgs dpsgwedcsf
     1141 dnrikaieec ksviesnris ressvdclke spnkqqeraq sqsgvdlqed vlvrerprsl
     1201 edlhqkkvgr akresrrmre leqaifslel lkvrslggis psedrrwste lvpeglqspr
     1261 gtpdsessqg slellsyees qksklesvis degdlqfpsp kissspkfds rdnalsasne
     1321 tssaehlkdg tmkemvvcss esitckpqlk dsfisnslpt ffyipqqdpl ktnsqldtsi
     1381 qrnkllened tagealtldi nretrryhcs gkdqivpsln tessnpvlkk leklntekee
     1441 rqkqlqqqne kemmeqirqq tdilekerka fktiekprig eclvapssyq skqrverpss
     1501 llslntsnkg elnvlgslsl kdaalaqkds ssahlppkdr pvtvfferkg spcqsstvke
     1561 lsktdrmgtq lnvacklsnn riskrehfrp tqsyshnsdd lsregnarpi fftpkdnmsi
     1621 plvskealns knpqlhkede pawkpvklag pgqreqvarp ahkkkarmar trsdfltrgt
     1681 fadgegdtee ddyddiiepl lsldqashce lgpapslgqa shsdsemtsq rfssvdeqak
     1741 lhktmsqgei tklavrqkas dsdirpqrak mrfwakgkqg ekkttrvkpt tqsevsplfa
     1801 gtdvipahqf pdelaayhpt pplspelpgs crkefkenke pspkakrkrs vkisnvalds
     1861 mhwqndsvqi iasvsdlksm defllkkvnd ldnedskkdt lvdvvfkkal kefrqnifsf
     1921 yssalamddg ksirykdlya lfeqilektm rleqrdslge spvrvwvntf kvfldeymne
     1981 fktsdctatk vpkterkkrr kketdlveeh nghifkatqy siptyceycs sliwimdras
     2041 vcklckyach kkcclkttak cskkydpels srqfgvelsr ltsedrtvpl vveklinyie
     2101 mhglytegiy rksgstnkik elrqgldtda esvnlddyni hviasvfkqw lrdlpnplmt
     2161 felyeeflra mglqerketi rgvysvidql srthlntler lifhlvrial qedtnrmsan
     2221 alaivfapci lrcpdttdpl qsvqdisktt tcvelivveq mnkykarlkd isslefaenk
     2281 aktrlslirr smkpvliavr fmnitrnsvs gkgrirrgny pgpsspvvvr lpsvsdvsee
     2341 tltseaamet diteqqqaam qqeervlteq ienlqkekee ltfemlvlep rasddetles
     2401 easigtadss enlnmeseya iseksersla lsslktagks epssklrkql kkqqdsldvv
     2461 dssvsslcls ntasshgtrk lfqiyskspf yraasgneal gmegplgqtk fledkpqfis
     2521 rgtfnpekgk qklknvknsp qktketpegt vmsgrrktvd pdctsnqqla lfgnnefmv
//
LOCUS       XP_047288525            2579 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-IXa isoform X12 [Homo sapiens].
ACCESSION   XP_047288525
VERSION     XP_047288525.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432569.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2579
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2579
                     /product="unconventional myosin-IXa isoform X12"
                     /calculated_mol_wt=295461
     Region          15..110
                     /region_name="RA_Myosin-IXa"
                     /note="Ras-associating (RA) domain found in Myosin-IXa;
                     cd17216"
                     /db_xref="CDD:340736"
     Region          160..945
                     /region_name="MYSc_Myo9"
                     /note="class IX myosin, motor domain; cd01385"
                     /db_xref="CDD:276836"
     Site            order(187..195,239..246,285..295,518..523)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276836"
     Site            187..195
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276836"
     Site            239..246
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276836"
     Site            285..295
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276836"
     Site            461
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:276836"
     Site            518..523
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276836"
     Site            order(547..558,561..570)
                     /site_type="active"
                     /note="relay loop [active]"
                     /db_xref="CDD:276836"
     Site            881..890
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276836"
     Site            order(893..920,924..945)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276836"
     Region          2008..2065
                     /region_name="C1_Myosin-IXa"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in unconventional myosin-IXa and similar proteins;
                     cd20883"
                     /db_xref="CDD:410433"
     Region          2074..2259
                     /region_name="RhoGAP_myosin_IX"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain present in class IX myosins. Class
                     IX myosins contain a characteristic head domain, a neck
                     domain, a tail domain which contains a C6H2-zinc binding
                     motif and a RhoGAP domain. Class...; cd04377"
                     /db_xref="CDD:239842"
     Site            order(2111,2148,2152,2221,2224..2225,2250)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239842"
     Site            2111
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239842"
     CDS             1..2579
                     /gene="MYO9A"
                     /gene_synonym="CMS24"
                     /coded_by="XM_047432569.1:140..7879"
                     /db_xref="GeneID:4649"
                     /db_xref="HGNC:HGNC:7608"
                     /db_xref="MIM:604875"
ORIGIN      
        1 mnindggrrr fednehtlri ypgaisegti ycpiparkns taaeviesli nklhldktkc
       61 yvlaevkefg geewilnptd cpvqrmmlwp rmalenrlsg edyrfllrek nldgsihygs
      121 lqswlrvtee rrrmmergfl pqpqqkdfdd lcslpdlnek tllenlrnrf khekiytyvg
      181 silivinpfk flpiynpkyv kmydnhqlgk lephiyavad vayhamlqrk knqcivisge
      241 sgsgktqstn flihhltals qkgfasgveq iilgagpvle afgnaktahn nnssrfgkfi
      301 qvnyqetgtv lgayvekyll eksrlvyqeh nernyhvfyy llagaseder safhlkqpee
      361 yhylnqdcft vegedlrhdf erlqlamemv gflpktrrqi fsllsailhl gnicykkkty
      421 rddsidicnp evlpivsell evkeemlfea lvtrktvtvg eklilpykla eavtvrnsma
      481 kslysalfdw ivfrinhall nskdlehntk tlsigvldif gfedyennsf eqfcinfane
      541 rlqhyfnqhi fkleqeeyrt egiswhnidy idntccinli skkptgllhl ldeesnfpqa
      601 tnqtlldkfk hqhednsyie fpavmepafi ikhyagkvky gvkdfreknt dhmrpdival
      661 lrssknafis gmigidpvav frwailraff ramvafreag krnihrktgi trknprtpls
      721 dlqgmnalne knqhdtfdia wngrtgirqs rlssgtslld kdgifansts skllerahgi
      781 ltrnknfksk palpkhllev nslkhltrlt lqdritksll hlhkkkkpps isaqfqasls
      841 klmetlgqae pyfvkcirsn aeklplrfsd vlvlrqlryt gmletvrirq sgysskysfq
      901 dfvshfhvll prniipskfn iqdffrkinl npdnyqvgkt mvflkeqerq hlqdllhqev
      961 lrriillqrw frvllcrqhf lhlrqasvii qrfwrnylnq kqvrdaavqk dafvmasaaa
     1021 llqaswrahl erqrylelra aaiviqqkwr dyyrrrhmaa iciqarwkay reskryqeqr
     1081 kkiillqstc rgfrarqrfk alkeqrlret kpevglvnik gygsleiqgs dpsgwedcsf
     1141 dnrikaieec ksviesnris ressvdclke spnkqqeraq sqsgvdlqed vlvrerprsl
     1201 edlhqkkvgr akresrrmre leqaifslel lkvrslggis psedrrwste lvpeglqspr
     1261 gtpdsessqg slellsyees qksklesvis degdlqfpsp kissspkfds rdnalsasne
     1321 tssaehlkdg tmkemvvcss esitckpqlk dsfisnslpt ffyipqqdpl ktnsqldtsi
     1381 qrnkllened tagealtldi nretrryhcs gkdqivpsln tessnpvlkk leklntekee
     1441 rqkqlqqqne kemmeqirqq tdilekerka fktiekprig eclvapssyq skqrverpss
     1501 llslntsnkg elnvlgslsl kdaalaqkds ssahlppkdr pvtvfferkg spcqsstvke
     1561 lsktdrmgtq lnvacklsnn riskrehfrp tqsyshnsdd lsregnarpi fftpkdnmsi
     1621 plvskealns knpqlhkede pawkpvklag pgqreqvarp ahkkkarmar trsdfltrgt
     1681 fadgegdtee ddyddiiepl lsldqashce lgpapslgqa shsdsemtsq rfssvdeqak
     1741 lhktmsqgei tklavrqkas dsdirpqrak mrfwakgkqg ekkttrvkpt tqsevsplfa
     1801 gtdvipahqf pdelaayhpt pplspelpgs crkefkenke pspkakrkrs vkisnvalds
     1861 mhwqndsvqi iasvsdlksm defllkkvnd ldnedskkdt lvdvvfkkal kefrqnifsf
     1921 yssalamddg ksirykdlya lfeqilektm rleqrdslge spvrvwvntf kvfldeymne
     1981 fktsdctatk vpkterkkrr kketdlveeh nghifkatqy siptyceycs sliwimdras
     2041 vcklckyach kkcclkttak cskkydpels srqfgvelsr ltsedrtvpl vveklinyie
     2101 mhglytegiy rksgstnkik elrqgldtda esvnlddyni hviasvfkqw lrdlpnplmt
     2161 felyeeflra mglqerketi rgvysvidql srthlntler lifhlvrial qedtnrmsan
     2221 alaivfapci lrcpdttdpl qsvqdisktt tcvelivveq mnkykarlkd isslefaenk
     2281 aktrlslirr smkpvliavr fmnitrnsvs gkgrirrgny pgpsspvvvr lpsvsdvsee
     2341 tltseaamet diteqqqaam qqeervlteq ienlqkekee ltfemlvlep rasddetles
     2401 easigtadss enlnmeseya iseksersla lsslktagks epssklrkql kkqqdsldvv
     2461 dssvsslcls ntasshgtrk lfqiyskspf yraasgneal gmegplgqtk fledkpqfis
     2521 rgtfnpekgk qklknvknsp qktketpegt vmsgrrktvd pdctsnqqla lfgnnefmv
//
LOCUS       XP_047288526            2579 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-IXa isoform X12 [Homo sapiens].
ACCESSION   XP_047288526
VERSION     XP_047288526.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432570.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2579
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2579
                     /product="unconventional myosin-IXa isoform X12"
                     /calculated_mol_wt=295461
     Region          15..110
                     /region_name="RA_Myosin-IXa"
                     /note="Ras-associating (RA) domain found in Myosin-IXa;
                     cd17216"
                     /db_xref="CDD:340736"
     Region          160..945
                     /region_name="MYSc_Myo9"
                     /note="class IX myosin, motor domain; cd01385"
                     /db_xref="CDD:276836"
     Site            order(187..195,239..246,285..295,518..523)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276836"
     Site            187..195
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276836"
     Site            239..246
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276836"
     Site            285..295
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276836"
     Site            461
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:276836"
     Site            518..523
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276836"
     Site            order(547..558,561..570)
                     /site_type="active"
                     /note="relay loop [active]"
                     /db_xref="CDD:276836"
     Site            881..890
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276836"
     Site            order(893..920,924..945)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276836"
     Region          2008..2065
                     /region_name="C1_Myosin-IXa"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in unconventional myosin-IXa and similar proteins;
                     cd20883"
                     /db_xref="CDD:410433"
     Region          2074..2259
                     /region_name="RhoGAP_myosin_IX"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain present in class IX myosins. Class
                     IX myosins contain a characteristic head domain, a neck
                     domain, a tail domain which contains a C6H2-zinc binding
                     motif and a RhoGAP domain. Class...; cd04377"
                     /db_xref="CDD:239842"
     Site            order(2111,2148,2152,2221,2224..2225,2250)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239842"
     Site            2111
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239842"
     CDS             1..2579
                     /gene="MYO9A"
                     /gene_synonym="CMS24"
                     /coded_by="XM_047432570.1:588..8327"
                     /db_xref="GeneID:4649"
                     /db_xref="HGNC:HGNC:7608"
                     /db_xref="MIM:604875"
ORIGIN      
        1 mnindggrrr fednehtlri ypgaisegti ycpiparkns taaeviesli nklhldktkc
       61 yvlaevkefg geewilnptd cpvqrmmlwp rmalenrlsg edyrfllrek nldgsihygs
      121 lqswlrvtee rrrmmergfl pqpqqkdfdd lcslpdlnek tllenlrnrf khekiytyvg
      181 silivinpfk flpiynpkyv kmydnhqlgk lephiyavad vayhamlqrk knqcivisge
      241 sgsgktqstn flihhltals qkgfasgveq iilgagpvle afgnaktahn nnssrfgkfi
      301 qvnyqetgtv lgayvekyll eksrlvyqeh nernyhvfyy llagaseder safhlkqpee
      361 yhylnqdcft vegedlrhdf erlqlamemv gflpktrrqi fsllsailhl gnicykkkty
      421 rddsidicnp evlpivsell evkeemlfea lvtrktvtvg eklilpykla eavtvrnsma
      481 kslysalfdw ivfrinhall nskdlehntk tlsigvldif gfedyennsf eqfcinfane
      541 rlqhyfnqhi fkleqeeyrt egiswhnidy idntccinli skkptgllhl ldeesnfpqa
      601 tnqtlldkfk hqhednsyie fpavmepafi ikhyagkvky gvkdfreknt dhmrpdival
      661 lrssknafis gmigidpvav frwailraff ramvafreag krnihrktgi trknprtpls
      721 dlqgmnalne knqhdtfdia wngrtgirqs rlssgtslld kdgifansts skllerahgi
      781 ltrnknfksk palpkhllev nslkhltrlt lqdritksll hlhkkkkpps isaqfqasls
      841 klmetlgqae pyfvkcirsn aeklplrfsd vlvlrqlryt gmletvrirq sgysskysfq
      901 dfvshfhvll prniipskfn iqdffrkinl npdnyqvgkt mvflkeqerq hlqdllhqev
      961 lrriillqrw frvllcrqhf lhlrqasvii qrfwrnylnq kqvrdaavqk dafvmasaaa
     1021 llqaswrahl erqrylelra aaiviqqkwr dyyrrrhmaa iciqarwkay reskryqeqr
     1081 kkiillqstc rgfrarqrfk alkeqrlret kpevglvnik gygsleiqgs dpsgwedcsf
     1141 dnrikaieec ksviesnris ressvdclke spnkqqeraq sqsgvdlqed vlvrerprsl
     1201 edlhqkkvgr akresrrmre leqaifslel lkvrslggis psedrrwste lvpeglqspr
     1261 gtpdsessqg slellsyees qksklesvis degdlqfpsp kissspkfds rdnalsasne
     1321 tssaehlkdg tmkemvvcss esitckpqlk dsfisnslpt ffyipqqdpl ktnsqldtsi
     1381 qrnkllened tagealtldi nretrryhcs gkdqivpsln tessnpvlkk leklntekee
     1441 rqkqlqqqne kemmeqirqq tdilekerka fktiekprig eclvapssyq skqrverpss
     1501 llslntsnkg elnvlgslsl kdaalaqkds ssahlppkdr pvtvfferkg spcqsstvke
     1561 lsktdrmgtq lnvacklsnn riskrehfrp tqsyshnsdd lsregnarpi fftpkdnmsi
     1621 plvskealns knpqlhkede pawkpvklag pgqreqvarp ahkkkarmar trsdfltrgt
     1681 fadgegdtee ddyddiiepl lsldqashce lgpapslgqa shsdsemtsq rfssvdeqak
     1741 lhktmsqgei tklavrqkas dsdirpqrak mrfwakgkqg ekkttrvkpt tqsevsplfa
     1801 gtdvipahqf pdelaayhpt pplspelpgs crkefkenke pspkakrkrs vkisnvalds
     1861 mhwqndsvqi iasvsdlksm defllkkvnd ldnedskkdt lvdvvfkkal kefrqnifsf
     1921 yssalamddg ksirykdlya lfeqilektm rleqrdslge spvrvwvntf kvfldeymne
     1981 fktsdctatk vpkterkkrr kketdlveeh nghifkatqy siptyceycs sliwimdras
     2041 vcklckyach kkcclkttak cskkydpels srqfgvelsr ltsedrtvpl vveklinyie
     2101 mhglytegiy rksgstnkik elrqgldtda esvnlddyni hviasvfkqw lrdlpnplmt
     2161 felyeeflra mglqerketi rgvysvidql srthlntler lifhlvrial qedtnrmsan
     2221 alaivfapci lrcpdttdpl qsvqdisktt tcvelivveq mnkykarlkd isslefaenk
     2281 aktrlslirr smkpvliavr fmnitrnsvs gkgrirrgny pgpsspvvvr lpsvsdvsee
     2341 tltseaamet diteqqqaam qqeervlteq ienlqkekee ltfemlvlep rasddetles
     2401 easigtadss enlnmeseya iseksersla lsslktagks epssklrkql kkqqdsldvv
     2461 dssvsslcls ntasshgtrk lfqiyskspf yraasgneal gmegplgqtk fledkpqfis
     2521 rgtfnpekgk qklknvknsp qktketpegt vmsgrrktvd pdctsnqqla lfgnnefmv
//
LOCUS       XP_047288527            2579 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-IXa isoform X12 [Homo sapiens].
ACCESSION   XP_047288527
VERSION     XP_047288527.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432571.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2579
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2579
                     /product="unconventional myosin-IXa isoform X12"
                     /calculated_mol_wt=295461
     Region          15..110
                     /region_name="RA_Myosin-IXa"
                     /note="Ras-associating (RA) domain found in Myosin-IXa;
                     cd17216"
                     /db_xref="CDD:340736"
     Region          160..945
                     /region_name="MYSc_Myo9"
                     /note="class IX myosin, motor domain; cd01385"
                     /db_xref="CDD:276836"
     Site            order(187..195,239..246,285..295,518..523)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276836"
     Site            187..195
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276836"
     Site            239..246
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276836"
     Site            285..295
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276836"
     Site            461
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:276836"
     Site            518..523
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276836"
     Site            order(547..558,561..570)
                     /site_type="active"
                     /note="relay loop [active]"
                     /db_xref="CDD:276836"
     Site            881..890
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276836"
     Site            order(893..920,924..945)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276836"
     Region          2008..2065
                     /region_name="C1_Myosin-IXa"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in unconventional myosin-IXa and similar proteins;
                     cd20883"
                     /db_xref="CDD:410433"
     Region          2074..2259
                     /region_name="RhoGAP_myosin_IX"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain present in class IX myosins. Class
                     IX myosins contain a characteristic head domain, a neck
                     domain, a tail domain which contains a C6H2-zinc binding
                     motif and a RhoGAP domain. Class...; cd04377"
                     /db_xref="CDD:239842"
     Site            order(2111,2148,2152,2221,2224..2225,2250)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239842"
     Site            2111
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239842"
     CDS             1..2579
                     /gene="MYO9A"
                     /gene_synonym="CMS24"
                     /coded_by="XM_047432571.1:346..8085"
                     /db_xref="GeneID:4649"
                     /db_xref="HGNC:HGNC:7608"
                     /db_xref="MIM:604875"
ORIGIN      
        1 mnindggrrr fednehtlri ypgaisegti ycpiparkns taaeviesli nklhldktkc
       61 yvlaevkefg geewilnptd cpvqrmmlwp rmalenrlsg edyrfllrek nldgsihygs
      121 lqswlrvtee rrrmmergfl pqpqqkdfdd lcslpdlnek tllenlrnrf khekiytyvg
      181 silivinpfk flpiynpkyv kmydnhqlgk lephiyavad vayhamlqrk knqcivisge
      241 sgsgktqstn flihhltals qkgfasgveq iilgagpvle afgnaktahn nnssrfgkfi
      301 qvnyqetgtv lgayvekyll eksrlvyqeh nernyhvfyy llagaseder safhlkqpee
      361 yhylnqdcft vegedlrhdf erlqlamemv gflpktrrqi fsllsailhl gnicykkkty
      421 rddsidicnp evlpivsell evkeemlfea lvtrktvtvg eklilpykla eavtvrnsma
      481 kslysalfdw ivfrinhall nskdlehntk tlsigvldif gfedyennsf eqfcinfane
      541 rlqhyfnqhi fkleqeeyrt egiswhnidy idntccinli skkptgllhl ldeesnfpqa
      601 tnqtlldkfk hqhednsyie fpavmepafi ikhyagkvky gvkdfreknt dhmrpdival
      661 lrssknafis gmigidpvav frwailraff ramvafreag krnihrktgi trknprtpls
      721 dlqgmnalne knqhdtfdia wngrtgirqs rlssgtslld kdgifansts skllerahgi
      781 ltrnknfksk palpkhllev nslkhltrlt lqdritksll hlhkkkkpps isaqfqasls
      841 klmetlgqae pyfvkcirsn aeklplrfsd vlvlrqlryt gmletvrirq sgysskysfq
      901 dfvshfhvll prniipskfn iqdffrkinl npdnyqvgkt mvflkeqerq hlqdllhqev
      961 lrriillqrw frvllcrqhf lhlrqasvii qrfwrnylnq kqvrdaavqk dafvmasaaa
     1021 llqaswrahl erqrylelra aaiviqqkwr dyyrrrhmaa iciqarwkay reskryqeqr
     1081 kkiillqstc rgfrarqrfk alkeqrlret kpevglvnik gygsleiqgs dpsgwedcsf
     1141 dnrikaieec ksviesnris ressvdclke spnkqqeraq sqsgvdlqed vlvrerprsl
     1201 edlhqkkvgr akresrrmre leqaifslel lkvrslggis psedrrwste lvpeglqspr
     1261 gtpdsessqg slellsyees qksklesvis degdlqfpsp kissspkfds rdnalsasne
     1321 tssaehlkdg tmkemvvcss esitckpqlk dsfisnslpt ffyipqqdpl ktnsqldtsi
     1381 qrnkllened tagealtldi nretrryhcs gkdqivpsln tessnpvlkk leklntekee
     1441 rqkqlqqqne kemmeqirqq tdilekerka fktiekprig eclvapssyq skqrverpss
     1501 llslntsnkg elnvlgslsl kdaalaqkds ssahlppkdr pvtvfferkg spcqsstvke
     1561 lsktdrmgtq lnvacklsnn riskrehfrp tqsyshnsdd lsregnarpi fftpkdnmsi
     1621 plvskealns knpqlhkede pawkpvklag pgqreqvarp ahkkkarmar trsdfltrgt
     1681 fadgegdtee ddyddiiepl lsldqashce lgpapslgqa shsdsemtsq rfssvdeqak
     1741 lhktmsqgei tklavrqkas dsdirpqrak mrfwakgkqg ekkttrvkpt tqsevsplfa
     1801 gtdvipahqf pdelaayhpt pplspelpgs crkefkenke pspkakrkrs vkisnvalds
     1861 mhwqndsvqi iasvsdlksm defllkkvnd ldnedskkdt lvdvvfkkal kefrqnifsf
     1921 yssalamddg ksirykdlya lfeqilektm rleqrdslge spvrvwvntf kvfldeymne
     1981 fktsdctatk vpkterkkrr kketdlveeh nghifkatqy siptyceycs sliwimdras
     2041 vcklckyach kkcclkttak cskkydpels srqfgvelsr ltsedrtvpl vveklinyie
     2101 mhglytegiy rksgstnkik elrqgldtda esvnlddyni hviasvfkqw lrdlpnplmt
     2161 felyeeflra mglqerketi rgvysvidql srthlntler lifhlvrial qedtnrmsan
     2221 alaivfapci lrcpdttdpl qsvqdisktt tcvelivveq mnkykarlkd isslefaenk
     2281 aktrlslirr smkpvliavr fmnitrnsvs gkgrirrgny pgpsspvvvr lpsvsdvsee
     2341 tltseaamet diteqqqaam qqeervlteq ienlqkekee ltfemlvlep rasddetles
     2401 easigtadss enlnmeseya iseksersla lsslktagks epssklrkql kkqqdsldvv
     2461 dssvsslcls ntasshgtrk lfqiyskspf yraasgneal gmegplgqtk fledkpqfis
     2521 rgtfnpekgk qklknvknsp qktketpegt vmsgrrktvd pdctsnqqla lfgnnefmv
//
LOCUS       XP_047288528            2578 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-IXa isoform X13 [Homo sapiens].
ACCESSION   XP_047288528
VERSION     XP_047288528.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432572.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2578
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2578
                     /product="unconventional myosin-IXa isoform X13"
                     /calculated_mol_wt=295333
     Region          15..110
                     /region_name="RA_Myosin-IXa"
                     /note="Ras-associating (RA) domain found in Myosin-IXa;
                     cd17216"
                     /db_xref="CDD:340736"
     Region          160..945
                     /region_name="MYSc_Myo9"
                     /note="class IX myosin, motor domain; cd01385"
                     /db_xref="CDD:276836"
     Site            order(187..195,239..246,285..295,518..523)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276836"
     Site            187..195
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276836"
     Site            239..246
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276836"
     Site            285..295
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276836"
     Site            461
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:276836"
     Site            518..523
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276836"
     Site            order(547..558,561..570)
                     /site_type="active"
                     /note="relay loop [active]"
                     /db_xref="CDD:276836"
     Site            881..890
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276836"
     Site            order(893..920,924..945)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276836"
     Region          2007..2064
                     /region_name="C1_Myosin-IXa"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in unconventional myosin-IXa and similar proteins;
                     cd20883"
                     /db_xref="CDD:410433"
     Region          2073..2258
                     /region_name="RhoGAP_myosin_IX"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain present in class IX myosins. Class
                     IX myosins contain a characteristic head domain, a neck
                     domain, a tail domain which contains a C6H2-zinc binding
                     motif and a RhoGAP domain. Class...; cd04377"
                     /db_xref="CDD:239842"
     Site            order(2110,2147,2151,2220,2223..2224,2249)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239842"
     Site            2110
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239842"
     CDS             1..2578
                     /gene="MYO9A"
                     /gene_synonym="CMS24"
                     /coded_by="XM_047432572.1:543..8279"
                     /db_xref="GeneID:4649"
                     /db_xref="HGNC:HGNC:7608"
                     /db_xref="MIM:604875"
ORIGIN      
        1 mnindggrrr fednehtlri ypgaisegti ycpiparkns taaeviesli nklhldktkc
       61 yvlaevkefg geewilnptd cpvqrmmlwp rmalenrlsg edyrfllrek nldgsihygs
      121 lqswlrvtee rrrmmergfl pqpqqkdfdd lcslpdlnek tllenlrnrf khekiytyvg
      181 silivinpfk flpiynpkyv kmydnhqlgk lephiyavad vayhamlqrk knqcivisge
      241 sgsgktqstn flihhltals qkgfasgveq iilgagpvle afgnaktahn nnssrfgkfi
      301 qvnyqetgtv lgayvekyll eksrlvyqeh nernyhvfyy llagaseder safhlkqpee
      361 yhylnqdcft vegedlrhdf erlqlamemv gflpktrrqi fsllsailhl gnicykkkty
      421 rddsidicnp evlpivsell evkeemlfea lvtrktvtvg eklilpykla eavtvrnsma
      481 kslysalfdw ivfrinhall nskdlehntk tlsigvldif gfedyennsf eqfcinfane
      541 rlqhyfnqhi fkleqeeyrt egiswhnidy idntccinli skkptgllhl ldeesnfpqa
      601 tnqtlldkfk hqhednsyie fpavmepafi ikhyagkvky gvkdfreknt dhmrpdival
      661 lrssknafis gmigidpvav frwailraff ramvafreag krnihrktgi trknprtpls
      721 dlqgmnalne knqhdtfdia wngrtgirqs rlssgtslld kdgifansts skllerahgi
      781 ltrnknfksk palpkhllev nslkhltrlt lqdritksll hlhkkkkpps isaqfqasls
      841 klmetlgqae pyfvkcirsn aeklplrfsd vlvlrqlryt gmletvrirq sgysskysfq
      901 dfvshfhvll prniipskfn iqdffrkinl npdnyqvgkt mvflkeqerq hlqdllhqev
      961 lrriillqrw frvllcrqhf lhlrqasvii qrfwrnylnq kqvrdaavqk dafvmasaaa
     1021 llqaswrahl erqrylelra aaiviqqkwr dyyrrrhmaa iciqarwkay reskryqeqr
     1081 kkiillqstc rgfrarqrfk alkeqrlret kpevglvnik gygsleiqgs dpsgwedcsf
     1141 dnrikaieec ksviesnris ressvdclke spnkqqeraq sqsgvdlqed vlvrerprsl
     1201 edlhqkkvgr akresrrmre leqaifslel lkvrslggis psedrrwste lvpeglqspr
     1261 gtpdsessqg slellsyees qksklesvis degdlqfpsp kissspkfds rdnalsasne
     1321 tssaehlkdg tmkemvvcss esitckpqlk dsfisnslpt ffyipqqdpl ktnsqldtsi
     1381 qrnkllened tagealtldi nretrryhcs gkdqivpsln tessnpvlkk leklntekee
     1441 rqkqlqqqne kemmeqirqq tdilekerka fktiekprig eclvapssyq skqrverpss
     1501 llslntsnkg elnvlgslsl kdaalaqkds ssahlppkdr pvtvfferkg spcqsstvke
     1561 lsktdrmgtq lnvacklsnn riskrehfrp tqsyshnsdd lsregnarpi fftpkdnmsi
     1621 plvskealns knpqlhkede pawkpvklag pgqrevarpa hkkkarmart rsdfltrgtf
     1681 adgegdteed dyddiiepll sldqashcel gpapslgqas hsdsemtsqr fssvdeqakl
     1741 hktmsqgeit klavrqkasd sdirpqrakm rfwakgkqge kkttrvkptt qsevsplfag
     1801 tdvipahqfp delaayhptp plspelpgsc rkefkenkep spkakrkrsv kisnvaldsm
     1861 hwqndsvqii asvsdlksmd efllkkvndl dnedskkdtl vdvvfkkalk efrqnifsfy
     1921 ssalamddgk sirykdlyal feqilektmr leqrdslges pvrvwvntfk vfldeymnef
     1981 ktsdctatkv pkterkkrrk ketdlveehn ghifkatqys iptyceycss liwimdrasv
     2041 cklckyachk kcclkttakc skkydpelss rqfgvelsrl tsedrtvplv veklinyiem
     2101 hglytegiyr ksgstnkike lrqgldtdae svnlddynih viasvfkqwl rdlpnplmtf
     2161 elyeeflram glqerketir gvysvidqls rthlntlerl ifhlvrialq edtnrmsana
     2221 laivfapcil rcpdttdplq svqdiskttt cvelivveqm nkykarlkdi sslefaenka
     2281 ktrlslirrs mkpvliavrf mnitrnsvsg kgrirrgnyp gpsspvvvrl psvsdvseet
     2341 ltseaametd iteqqqaamq qeervlteqi enlqkekeel tfemlvlepr asddetlese
     2401 asigtadsse nlnmeseyai sekserslal sslktagkse pssklrkqlk kqqdsldvvd
     2461 ssvsslclsn tasshgtrkl fqiyskspfy raasgnealg megplgqtkf ledkpqfisr
     2521 gtfnpekgkq klknvknspq ktketpegtv msgrrktvdp dctsnqqlal fgnnefmv
//
LOCUS       XP_047288529            2578 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-IXa isoform X13 [Homo sapiens].
ACCESSION   XP_047288529
VERSION     XP_047288529.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432573.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2578
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2578
                     /product="unconventional myosin-IXa isoform X13"
                     /calculated_mol_wt=295333
     Region          15..110
                     /region_name="RA_Myosin-IXa"
                     /note="Ras-associating (RA) domain found in Myosin-IXa;
                     cd17216"
                     /db_xref="CDD:340736"
     Region          160..945
                     /region_name="MYSc_Myo9"
                     /note="class IX myosin, motor domain; cd01385"
                     /db_xref="CDD:276836"
     Site            order(187..195,239..246,285..295,518..523)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276836"
     Site            187..195
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276836"
     Site            239..246
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276836"
     Site            285..295
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276836"
     Site            461
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:276836"
     Site            518..523
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276836"
     Site            order(547..558,561..570)
                     /site_type="active"
                     /note="relay loop [active]"
                     /db_xref="CDD:276836"
     Site            881..890
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276836"
     Site            order(893..920,924..945)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276836"
     Region          2007..2064
                     /region_name="C1_Myosin-IXa"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in unconventional myosin-IXa and similar proteins;
                     cd20883"
                     /db_xref="CDD:410433"
     Region          2073..2258
                     /region_name="RhoGAP_myosin_IX"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain present in class IX myosins. Class
                     IX myosins contain a characteristic head domain, a neck
                     domain, a tail domain which contains a C6H2-zinc binding
                     motif and a RhoGAP domain. Class...; cd04377"
                     /db_xref="CDD:239842"
     Site            order(2110,2147,2151,2220,2223..2224,2249)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239842"
     Site            2110
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239842"
     CDS             1..2578
                     /gene="MYO9A"
                     /gene_synonym="CMS24"
                     /coded_by="XM_047432573.1:140..7876"
                     /db_xref="GeneID:4649"
                     /db_xref="HGNC:HGNC:7608"
                     /db_xref="MIM:604875"
ORIGIN      
        1 mnindggrrr fednehtlri ypgaisegti ycpiparkns taaeviesli nklhldktkc
       61 yvlaevkefg geewilnptd cpvqrmmlwp rmalenrlsg edyrfllrek nldgsihygs
      121 lqswlrvtee rrrmmergfl pqpqqkdfdd lcslpdlnek tllenlrnrf khekiytyvg
      181 silivinpfk flpiynpkyv kmydnhqlgk lephiyavad vayhamlqrk knqcivisge
      241 sgsgktqstn flihhltals qkgfasgveq iilgagpvle afgnaktahn nnssrfgkfi
      301 qvnyqetgtv lgayvekyll eksrlvyqeh nernyhvfyy llagaseder safhlkqpee
      361 yhylnqdcft vegedlrhdf erlqlamemv gflpktrrqi fsllsailhl gnicykkkty
      421 rddsidicnp evlpivsell evkeemlfea lvtrktvtvg eklilpykla eavtvrnsma
      481 kslysalfdw ivfrinhall nskdlehntk tlsigvldif gfedyennsf eqfcinfane
      541 rlqhyfnqhi fkleqeeyrt egiswhnidy idntccinli skkptgllhl ldeesnfpqa
      601 tnqtlldkfk hqhednsyie fpavmepafi ikhyagkvky gvkdfreknt dhmrpdival
      661 lrssknafis gmigidpvav frwailraff ramvafreag krnihrktgi trknprtpls
      721 dlqgmnalne knqhdtfdia wngrtgirqs rlssgtslld kdgifansts skllerahgi
      781 ltrnknfksk palpkhllev nslkhltrlt lqdritksll hlhkkkkpps isaqfqasls
      841 klmetlgqae pyfvkcirsn aeklplrfsd vlvlrqlryt gmletvrirq sgysskysfq
      901 dfvshfhvll prniipskfn iqdffrkinl npdnyqvgkt mvflkeqerq hlqdllhqev
      961 lrriillqrw frvllcrqhf lhlrqasvii qrfwrnylnq kqvrdaavqk dafvmasaaa
     1021 llqaswrahl erqrylelra aaiviqqkwr dyyrrrhmaa iciqarwkay reskryqeqr
     1081 kkiillqstc rgfrarqrfk alkeqrlret kpevglvnik gygsleiqgs dpsgwedcsf
     1141 dnrikaieec ksviesnris ressvdclke spnkqqeraq sqsgvdlqed vlvrerprsl
     1201 edlhqkkvgr akresrrmre leqaifslel lkvrslggis psedrrwste lvpeglqspr
     1261 gtpdsessqg slellsyees qksklesvis degdlqfpsp kissspkfds rdnalsasne
     1321 tssaehlkdg tmkemvvcss esitckpqlk dsfisnslpt ffyipqqdpl ktnsqldtsi
     1381 qrnkllened tagealtldi nretrryhcs gkdqivpsln tessnpvlkk leklntekee
     1441 rqkqlqqqne kemmeqirqq tdilekerka fktiekprig eclvapssyq skqrverpss
     1501 llslntsnkg elnvlgslsl kdaalaqkds ssahlppkdr pvtvfferkg spcqsstvke
     1561 lsktdrmgtq lnvacklsnn riskrehfrp tqsyshnsdd lsregnarpi fftpkdnmsi
     1621 plvskealns knpqlhkede pawkpvklag pgqrevarpa hkkkarmart rsdfltrgtf
     1681 adgegdteed dyddiiepll sldqashcel gpapslgqas hsdsemtsqr fssvdeqakl
     1741 hktmsqgeit klavrqkasd sdirpqrakm rfwakgkqge kkttrvkptt qsevsplfag
     1801 tdvipahqfp delaayhptp plspelpgsc rkefkenkep spkakrkrsv kisnvaldsm
     1861 hwqndsvqii asvsdlksmd efllkkvndl dnedskkdtl vdvvfkkalk efrqnifsfy
     1921 ssalamddgk sirykdlyal feqilektmr leqrdslges pvrvwvntfk vfldeymnef
     1981 ktsdctatkv pkterkkrrk ketdlveehn ghifkatqys iptyceycss liwimdrasv
     2041 cklckyachk kcclkttakc skkydpelss rqfgvelsrl tsedrtvplv veklinyiem
     2101 hglytegiyr ksgstnkike lrqgldtdae svnlddynih viasvfkqwl rdlpnplmtf
     2161 elyeeflram glqerketir gvysvidqls rthlntlerl ifhlvrialq edtnrmsana
     2221 laivfapcil rcpdttdplq svqdiskttt cvelivveqm nkykarlkdi sslefaenka
     2281 ktrlslirrs mkpvliavrf mnitrnsvsg kgrirrgnyp gpsspvvvrl psvsdvseet
     2341 ltseaametd iteqqqaamq qeervlteqi enlqkekeel tfemlvlepr asddetlese
     2401 asigtadsse nlnmeseyai sekserslal sslktagkse pssklrkqlk kqqdsldvvd
     2461 ssvsslclsn tasshgtrkl fqiyskspfy raasgnealg megplgqtkf ledkpqfisr
     2521 gtfnpekgkq klknvknspq ktketpegtv msgrrktvdp dctsnqqlal fgnnefmv
//
LOCUS       XP_011519924            2566 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-IXa isoform X14 [Homo sapiens].
ACCESSION   XP_011519924
VERSION     XP_011519924.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521622.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2566
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2566
                     /product="unconventional myosin-IXa isoform X14"
                     /calculated_mol_wt=294603
     Region          15..110
                     /region_name="RA_Myosin-IXa"
                     /note="Ras-associating (RA) domain found in Myosin-IXa;
                     cd17216"
                     /db_xref="CDD:340736"
     Region          160..1004
                     /region_name="MYSc_Myo9"
                     /note="class IX myosin, motor domain; cd01385"
                     /db_xref="CDD:276836"
     Site            order(187..195,239..246,285..295,537..542)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276836"
     Site            187..195
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276836"
     Site            239..246
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276836"
     Site            285..295
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276836"
     Site            480
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:276836"
     Site            537..542
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276836"
     Site            order(566..577,580..589)
                     /site_type="active"
                     /note="relay loop [active]"
                     /db_xref="CDD:276836"
     Site            940..949
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276836"
     Site            order(952..979,983..1004)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276836"
     Region          1995..2052
                     /region_name="C1_Myosin-IXa"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in unconventional myosin-IXa and similar proteins;
                     cd20883"
                     /db_xref="CDD:410433"
     Region          2061..2246
                     /region_name="RhoGAP_myosin_IX"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain present in class IX myosins. Class
                     IX myosins contain a characteristic head domain, a neck
                     domain, a tail domain which contains a C6H2-zinc binding
                     motif and a RhoGAP domain. Class...; cd04377"
                     /db_xref="CDD:239842"
     Site            order(2098,2135,2139,2208,2211..2212,2237)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239842"
     Site            2098
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239842"
     CDS             1..2566
                     /gene="MYO9A"
                     /gene_synonym="CMS24"
                     /coded_by="XM_011521622.4:543..8243"
                     /db_xref="GeneID:4649"
                     /db_xref="HGNC:HGNC:7608"
                     /db_xref="MIM:604875"
ORIGIN      
        1 mnindggrrr fednehtlri ypgaisegti ycpiparkns taaeviesli nklhldktkc
       61 yvlaevkefg geewilnptd cpvqrmmlwp rmalenrlsg edyrfllrek nldgsihygs
      121 lqswlrvtee rrrmmergfl pqpqqkdfdd lcslpdlnek tllenlrnrf khekiytyvg
      181 silivinpfk flpiynpkyv kmydnhqlgk lephiyavad vayhamlqrk knqcivisge
      241 sgsgktqstn flihhltals qkgfasgveq iilgagpvle afgnaktahn nnssrfgkfi
      301 qvnyqetgtv lgayvekyll eksrlvyqeh nernyhvfyy llagaseder safhlkqpee
      361 yhylnqitkk plrqswddyc ydsepdcftv egedlrhdfe rlqlamemvg flpktrrqif
      421 sllsailhlg nicykkktyr ddsidicnpe vlpivselle vkeemlfeal vtrktvtvge
      481 klilpyklae avtvrnsmak slysalfdwi vfrinhalln skdlehntkt lsigvldifg
      541 fedyennsfe qfcinfaner lqhyfnqhif kleqeeyrte giswhnidyi dntccinlis
      601 kkptgllhll deesnfpqat nqtlldkfkh qhednsyief pavmepafii khyagkvkyg
      661 vkdfrekntd hmrpdivall rssknafisg migidpvavf rwailraffr amvafreagk
      721 rnihrktghd dtapcailks mdsfsflqhp vhqrsleilq rckeekysit rknprtplsd
      781 lqgmnalnek nqhdtfdiaw ngrtgirqsr lssgtslldk dgifanstss kllerahgil
      841 trnknfkskp alpkhllevn slkhltrltl qdritksllh lhkkkkppsi saqfqaslsk
      901 lmetlgqaep yfvkcirsna eklplrfsdv lvlrqlrytg mletvrirqs gysskysfqd
      961 fvshfhvllp rniipskfni qdffrkinln pdnyqvgktm vflkeqerqh lqdllhqevl
     1021 rriillqrwf rvllcrqhfl hlrqasviiq rfwrnylnqk qvrdaavqkd afvmasaaal
     1081 lqaswrahle rqrylelraa aiviqqkwrd yyrrrhmaai ciqarwkayr eskryqeqrk
     1141 kiillqstcr gfrarqrfka lkeqrlretk pevglvnikg ygsleiqgsd psgwedcsfd
     1201 nrikaieeck sviesnrisr essvdclkes pnkqqeraqs qsgvdlqedv lvrerprsle
     1261 dlhqkkvgra kresrrmrel eqaifslell kvrslggisp sedrrwstel vpeglqsprg
     1321 tpdsessqgs lellsyeesq ksklesvisd egdlqfpspk issspkfdsr dnalsasnet
     1381 ssaehlkdgt mkemvvcsse sitckpqlkd sfisnslptf fyipqqdplk tnsqldtsiq
     1441 rnkllenedt agealtldin retrryhcsg kdqivpslnt essnpvlkkl eklntekeer
     1501 qkqlqqqnek emmeqirqqt dilekerkaf ktiekprige clvapssyqs kqrverpssl
     1561 lslntsnkge lnvlgslslk daalaqkdss sahlppkdrp vtvfferkgs pcqsstvkel
     1621 sktdrmgtql nvacklsnnr iskrehfrpt qsyshnsddl sregnarpif ftpkdnmsip
     1681 lvskealnsk npqlhkedep awkpvklagp gqretsqrfs svdeqaklhk tmsqgeitkl
     1741 avrqkasdsd irpqrakmrf wakgkqgekk ttrvkpttqs evsplfagtd vipahqfpde
     1801 laayhptppl spelpgscrk efkenkepsp kakrkrsvki snvaldsmhw qndsvqiias
     1861 vsdlksmdef llkkvndldn edskkdtlvd vvfkkalkef rqnifsfyss alamddgksi
     1921 rykdlyalfe qilektmrle qrdslgespv rvwvntfkvf ldeymnefkt sdctatkvpk
     1981 terkkrrkke tdlveehngh ifkatqysip tyceycssli wimdrasvck lckyachkkc
     2041 clkttakcsk kydpelssrq fgvelsrlts edrtvplvve klinyiemhg lytegiyrks
     2101 gstnkikelr qgldtdaesv nlddynihvi asvfkqwlrd lpnplmtfel yeeflramgl
     2161 qerketirgv ysvidqlsrt hlntlerlif hlvrialqed tnrmsanala ivfapcilrc
     2221 pdttdplqsv qdisktttcv elivveqmnk ykarlkdiss lefaenkakt rlslirrsmk
     2281 pvliavrfmn itrnsvsgkg rirrgnypgp sspvvvrlps vsdvseetlt seaametdit
     2341 eqqqaamqqe ervlteqien lqkekeeltf emlvlepras ddetleseas igtadssenl
     2401 nmeseyaise kserslalss lktagkseps sklrkqlkkq qdsldvvdss vsslclsnta
     2461 sshgtrklfq iyskspfyra asgnealgme gplgqtkfle dkpqfisrgt fnpekgkqkl
     2521 knvknspqkt ketpegtvms grrktvdpdc tsnqqlalfg nnefmv
//
LOCUS       XP_047288531            2566 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-IXa isoform X14 [Homo sapiens].
ACCESSION   XP_047288531
VERSION     XP_047288531.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432575.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2566
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2566
                     /product="unconventional myosin-IXa isoform X14"
                     /calculated_mol_wt=294603
     Region          15..110
                     /region_name="RA_Myosin-IXa"
                     /note="Ras-associating (RA) domain found in Myosin-IXa;
                     cd17216"
                     /db_xref="CDD:340736"
     Region          160..1004
                     /region_name="MYSc_Myo9"
                     /note="class IX myosin, motor domain; cd01385"
                     /db_xref="CDD:276836"
     Site            order(187..195,239..246,285..295,537..542)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276836"
     Site            187..195
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276836"
     Site            239..246
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276836"
     Site            285..295
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276836"
     Site            480
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:276836"
     Site            537..542
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276836"
     Site            order(566..577,580..589)
                     /site_type="active"
                     /note="relay loop [active]"
                     /db_xref="CDD:276836"
     Site            940..949
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276836"
     Site            order(952..979,983..1004)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276836"
     Region          1995..2052
                     /region_name="C1_Myosin-IXa"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in unconventional myosin-IXa and similar proteins;
                     cd20883"
                     /db_xref="CDD:410433"
     Region          2061..2246
                     /region_name="RhoGAP_myosin_IX"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain present in class IX myosins. Class
                     IX myosins contain a characteristic head domain, a neck
                     domain, a tail domain which contains a C6H2-zinc binding
                     motif and a RhoGAP domain. Class...; cd04377"
                     /db_xref="CDD:239842"
     Site            order(2098,2135,2139,2208,2211..2212,2237)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239842"
     Site            2098
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239842"
     CDS             1..2566
                     /gene="MYO9A"
                     /gene_synonym="CMS24"
                     /coded_by="XM_047432575.1:140..7840"
                     /db_xref="GeneID:4649"
                     /db_xref="HGNC:HGNC:7608"
                     /db_xref="MIM:604875"
ORIGIN      
        1 mnindggrrr fednehtlri ypgaisegti ycpiparkns taaeviesli nklhldktkc
       61 yvlaevkefg geewilnptd cpvqrmmlwp rmalenrlsg edyrfllrek nldgsihygs
      121 lqswlrvtee rrrmmergfl pqpqqkdfdd lcslpdlnek tllenlrnrf khekiytyvg
      181 silivinpfk flpiynpkyv kmydnhqlgk lephiyavad vayhamlqrk knqcivisge
      241 sgsgktqstn flihhltals qkgfasgveq iilgagpvle afgnaktahn nnssrfgkfi
      301 qvnyqetgtv lgayvekyll eksrlvyqeh nernyhvfyy llagaseder safhlkqpee
      361 yhylnqitkk plrqswddyc ydsepdcftv egedlrhdfe rlqlamemvg flpktrrqif
      421 sllsailhlg nicykkktyr ddsidicnpe vlpivselle vkeemlfeal vtrktvtvge
      481 klilpyklae avtvrnsmak slysalfdwi vfrinhalln skdlehntkt lsigvldifg
      541 fedyennsfe qfcinfaner lqhyfnqhif kleqeeyrte giswhnidyi dntccinlis
      601 kkptgllhll deesnfpqat nqtlldkfkh qhednsyief pavmepafii khyagkvkyg
      661 vkdfrekntd hmrpdivall rssknafisg migidpvavf rwailraffr amvafreagk
      721 rnihrktghd dtapcailks mdsfsflqhp vhqrsleilq rckeekysit rknprtplsd
      781 lqgmnalnek nqhdtfdiaw ngrtgirqsr lssgtslldk dgifanstss kllerahgil
      841 trnknfkskp alpkhllevn slkhltrltl qdritksllh lhkkkkppsi saqfqaslsk
      901 lmetlgqaep yfvkcirsna eklplrfsdv lvlrqlrytg mletvrirqs gysskysfqd
      961 fvshfhvllp rniipskfni qdffrkinln pdnyqvgktm vflkeqerqh lqdllhqevl
     1021 rriillqrwf rvllcrqhfl hlrqasviiq rfwrnylnqk qvrdaavqkd afvmasaaal
     1081 lqaswrahle rqrylelraa aiviqqkwrd yyrrrhmaai ciqarwkayr eskryqeqrk
     1141 kiillqstcr gfrarqrfka lkeqrlretk pevglvnikg ygsleiqgsd psgwedcsfd
     1201 nrikaieeck sviesnrisr essvdclkes pnkqqeraqs qsgvdlqedv lvrerprsle
     1261 dlhqkkvgra kresrrmrel eqaifslell kvrslggisp sedrrwstel vpeglqsprg
     1321 tpdsessqgs lellsyeesq ksklesvisd egdlqfpspk issspkfdsr dnalsasnet
     1381 ssaehlkdgt mkemvvcsse sitckpqlkd sfisnslptf fyipqqdplk tnsqldtsiq
     1441 rnkllenedt agealtldin retrryhcsg kdqivpslnt essnpvlkkl eklntekeer
     1501 qkqlqqqnek emmeqirqqt dilekerkaf ktiekprige clvapssyqs kqrverpssl
     1561 lslntsnkge lnvlgslslk daalaqkdss sahlppkdrp vtvfferkgs pcqsstvkel
     1621 sktdrmgtql nvacklsnnr iskrehfrpt qsyshnsddl sregnarpif ftpkdnmsip
     1681 lvskealnsk npqlhkedep awkpvklagp gqretsqrfs svdeqaklhk tmsqgeitkl
     1741 avrqkasdsd irpqrakmrf wakgkqgekk ttrvkpttqs evsplfagtd vipahqfpde
     1801 laayhptppl spelpgscrk efkenkepsp kakrkrsvki snvaldsmhw qndsvqiias
     1861 vsdlksmdef llkkvndldn edskkdtlvd vvfkkalkef rqnifsfyss alamddgksi
     1921 rykdlyalfe qilektmrle qrdslgespv rvwvntfkvf ldeymnefkt sdctatkvpk
     1981 terkkrrkke tdlveehngh ifkatqysip tyceycssli wimdrasvck lckyachkkc
     2041 clkttakcsk kydpelssrq fgvelsrlts edrtvplvve klinyiemhg lytegiyrks
     2101 gstnkikelr qgldtdaesv nlddynihvi asvfkqwlrd lpnplmtfel yeeflramgl
     2161 qerketirgv ysvidqlsrt hlntlerlif hlvrialqed tnrmsanala ivfapcilrc
     2221 pdttdplqsv qdisktttcv elivveqmnk ykarlkdiss lefaenkakt rlslirrsmk
     2281 pvliavrfmn itrnsvsgkg rirrgnypgp sspvvvrlps vsdvseetlt seaametdit
     2341 eqqqaamqqe ervlteqien lqkekeeltf emlvlepras ddetleseas igtadssenl
     2401 nmeseyaise kserslalss lktagkseps sklrkqlkkq qdsldvvdss vsslclsnta
     2461 sshgtrklfq iyskspfyra asgnealgme gplgqtkfle dkpqfisrgt fnpekgkqkl
     2521 knvknspqkt ketpegtvms grrktvdpdc tsnqqlalfg nnefmv
//
LOCUS       XP_016877718            2566 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-IXa isoform X14 [Homo sapiens].
ACCESSION   XP_016877718
VERSION     XP_016877718.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022229.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2566
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2566
                     /product="unconventional myosin-IXa isoform X14"
                     /calculated_mol_wt=294603
     Region          15..110
                     /region_name="RA_Myosin-IXa"
                     /note="Ras-associating (RA) domain found in Myosin-IXa;
                     cd17216"
                     /db_xref="CDD:340736"
     Region          160..1004
                     /region_name="MYSc_Myo9"
                     /note="class IX myosin, motor domain; cd01385"
                     /db_xref="CDD:276836"
     Site            order(187..195,239..246,285..295,537..542)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276836"
     Site            187..195
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276836"
     Site            239..246
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276836"
     Site            285..295
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276836"
     Site            480
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:276836"
     Site            537..542
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276836"
     Site            order(566..577,580..589)
                     /site_type="active"
                     /note="relay loop [active]"
                     /db_xref="CDD:276836"
     Site            940..949
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276836"
     Site            order(952..979,983..1004)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276836"
     Region          1995..2052
                     /region_name="C1_Myosin-IXa"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in unconventional myosin-IXa and similar proteins;
                     cd20883"
                     /db_xref="CDD:410433"
     Region          2061..2246
                     /region_name="RhoGAP_myosin_IX"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain present in class IX myosins. Class
                     IX myosins contain a characteristic head domain, a neck
                     domain, a tail domain which contains a C6H2-zinc binding
                     motif and a RhoGAP domain. Class...; cd04377"
                     /db_xref="CDD:239842"
     Site            order(2098,2135,2139,2208,2211..2212,2237)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239842"
     Site            2098
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239842"
     CDS             1..2566
                     /gene="MYO9A"
                     /gene_synonym="CMS24"
                     /coded_by="XM_017022229.2:588..8288"
                     /db_xref="GeneID:4649"
                     /db_xref="HGNC:HGNC:7608"
                     /db_xref="MIM:604875"
ORIGIN      
        1 mnindggrrr fednehtlri ypgaisegti ycpiparkns taaeviesli nklhldktkc
       61 yvlaevkefg geewilnptd cpvqrmmlwp rmalenrlsg edyrfllrek nldgsihygs
      121 lqswlrvtee rrrmmergfl pqpqqkdfdd lcslpdlnek tllenlrnrf khekiytyvg
      181 silivinpfk flpiynpkyv kmydnhqlgk lephiyavad vayhamlqrk knqcivisge
      241 sgsgktqstn flihhltals qkgfasgveq iilgagpvle afgnaktahn nnssrfgkfi
      301 qvnyqetgtv lgayvekyll eksrlvyqeh nernyhvfyy llagaseder safhlkqpee
      361 yhylnqitkk plrqswddyc ydsepdcftv egedlrhdfe rlqlamemvg flpktrrqif
      421 sllsailhlg nicykkktyr ddsidicnpe vlpivselle vkeemlfeal vtrktvtvge
      481 klilpyklae avtvrnsmak slysalfdwi vfrinhalln skdlehntkt lsigvldifg
      541 fedyennsfe qfcinfaner lqhyfnqhif kleqeeyrte giswhnidyi dntccinlis
      601 kkptgllhll deesnfpqat nqtlldkfkh qhednsyief pavmepafii khyagkvkyg
      661 vkdfrekntd hmrpdivall rssknafisg migidpvavf rwailraffr amvafreagk
      721 rnihrktghd dtapcailks mdsfsflqhp vhqrsleilq rckeekysit rknprtplsd
      781 lqgmnalnek nqhdtfdiaw ngrtgirqsr lssgtslldk dgifanstss kllerahgil
      841 trnknfkskp alpkhllevn slkhltrltl qdritksllh lhkkkkppsi saqfqaslsk
      901 lmetlgqaep yfvkcirsna eklplrfsdv lvlrqlrytg mletvrirqs gysskysfqd
      961 fvshfhvllp rniipskfni qdffrkinln pdnyqvgktm vflkeqerqh lqdllhqevl
     1021 rriillqrwf rvllcrqhfl hlrqasviiq rfwrnylnqk qvrdaavqkd afvmasaaal
     1081 lqaswrahle rqrylelraa aiviqqkwrd yyrrrhmaai ciqarwkayr eskryqeqrk
     1141 kiillqstcr gfrarqrfka lkeqrlretk pevglvnikg ygsleiqgsd psgwedcsfd
     1201 nrikaieeck sviesnrisr essvdclkes pnkqqeraqs qsgvdlqedv lvrerprsle
     1261 dlhqkkvgra kresrrmrel eqaifslell kvrslggisp sedrrwstel vpeglqsprg
     1321 tpdsessqgs lellsyeesq ksklesvisd egdlqfpspk issspkfdsr dnalsasnet
     1381 ssaehlkdgt mkemvvcsse sitckpqlkd sfisnslptf fyipqqdplk tnsqldtsiq
     1441 rnkllenedt agealtldin retrryhcsg kdqivpslnt essnpvlkkl eklntekeer
     1501 qkqlqqqnek emmeqirqqt dilekerkaf ktiekprige clvapssyqs kqrverpssl
     1561 lslntsnkge lnvlgslslk daalaqkdss sahlppkdrp vtvfferkgs pcqsstvkel
     1621 sktdrmgtql nvacklsnnr iskrehfrpt qsyshnsddl sregnarpif ftpkdnmsip
     1681 lvskealnsk npqlhkedep awkpvklagp gqretsqrfs svdeqaklhk tmsqgeitkl
     1741 avrqkasdsd irpqrakmrf wakgkqgekk ttrvkpttqs evsplfagtd vipahqfpde
     1801 laayhptppl spelpgscrk efkenkepsp kakrkrsvki snvaldsmhw qndsvqiias
     1861 vsdlksmdef llkkvndldn edskkdtlvd vvfkkalkef rqnifsfyss alamddgksi
     1921 rykdlyalfe qilektmrle qrdslgespv rvwvntfkvf ldeymnefkt sdctatkvpk
     1981 terkkrrkke tdlveehngh ifkatqysip tyceycssli wimdrasvck lckyachkkc
     2041 clkttakcsk kydpelssrq fgvelsrlts edrtvplvve klinyiemhg lytegiyrks
     2101 gstnkikelr qgldtdaesv nlddynihvi asvfkqwlrd lpnplmtfel yeeflramgl
     2161 qerketirgv ysvidqlsrt hlntlerlif hlvrialqed tnrmsanala ivfapcilrc
     2221 pdttdplqsv qdisktttcv elivveqmnk ykarlkdiss lefaenkakt rlslirrsmk
     2281 pvliavrfmn itrnsvsgkg rirrgnypgp sspvvvrlps vsdvseetlt seaametdit
     2341 eqqqaamqqe ervlteqien lqkekeeltf emlvlepras ddetleseas igtadssenl
     2401 nmeseyaise kserslalss lktagkseps sklrkqlkkq qdsldvvdss vsslclsnta
     2461 sshgtrklfq iyskspfyra asgnealgme gplgqtkfle dkpqfisrgt fnpekgkqkl
     2521 knvknspqkt ketpegtvms grrktvdpdc tsnqqlalfg nnefmv
//
LOCUS       XP_047288532            2566 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-IXa isoform X14 [Homo sapiens].
ACCESSION   XP_047288532
VERSION     XP_047288532.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432576.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2566
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2566
                     /product="unconventional myosin-IXa isoform X14"
                     /calculated_mol_wt=294603
     Region          15..110
                     /region_name="RA_Myosin-IXa"
                     /note="Ras-associating (RA) domain found in Myosin-IXa;
                     cd17216"
                     /db_xref="CDD:340736"
     Region          160..1004
                     /region_name="MYSc_Myo9"
                     /note="class IX myosin, motor domain; cd01385"
                     /db_xref="CDD:276836"
     Site            order(187..195,239..246,285..295,537..542)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276836"
     Site            187..195
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276836"
     Site            239..246
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276836"
     Site            285..295
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276836"
     Site            480
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:276836"
     Site            537..542
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276836"
     Site            order(566..577,580..589)
                     /site_type="active"
                     /note="relay loop [active]"
                     /db_xref="CDD:276836"
     Site            940..949
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276836"
     Site            order(952..979,983..1004)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276836"
     Region          1995..2052
                     /region_name="C1_Myosin-IXa"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in unconventional myosin-IXa and similar proteins;
                     cd20883"
                     /db_xref="CDD:410433"
     Region          2061..2246
                     /region_name="RhoGAP_myosin_IX"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain present in class IX myosins. Class
                     IX myosins contain a characteristic head domain, a neck
                     domain, a tail domain which contains a C6H2-zinc binding
                     motif and a RhoGAP domain. Class...; cd04377"
                     /db_xref="CDD:239842"
     Site            order(2098,2135,2139,2208,2211..2212,2237)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239842"
     Site            2098
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239842"
     CDS             1..2566
                     /gene="MYO9A"
                     /gene_synonym="CMS24"
                     /coded_by="XM_047432576.1:368..8068"
                     /db_xref="GeneID:4649"
                     /db_xref="HGNC:HGNC:7608"
                     /db_xref="MIM:604875"
ORIGIN      
        1 mnindggrrr fednehtlri ypgaisegti ycpiparkns taaeviesli nklhldktkc
       61 yvlaevkefg geewilnptd cpvqrmmlwp rmalenrlsg edyrfllrek nldgsihygs
      121 lqswlrvtee rrrmmergfl pqpqqkdfdd lcslpdlnek tllenlrnrf khekiytyvg
      181 silivinpfk flpiynpkyv kmydnhqlgk lephiyavad vayhamlqrk knqcivisge
      241 sgsgktqstn flihhltals qkgfasgveq iilgagpvle afgnaktahn nnssrfgkfi
      301 qvnyqetgtv lgayvekyll eksrlvyqeh nernyhvfyy llagaseder safhlkqpee
      361 yhylnqitkk plrqswddyc ydsepdcftv egedlrhdfe rlqlamemvg flpktrrqif
      421 sllsailhlg nicykkktyr ddsidicnpe vlpivselle vkeemlfeal vtrktvtvge
      481 klilpyklae avtvrnsmak slysalfdwi vfrinhalln skdlehntkt lsigvldifg
      541 fedyennsfe qfcinfaner lqhyfnqhif kleqeeyrte giswhnidyi dntccinlis
      601 kkptgllhll deesnfpqat nqtlldkfkh qhednsyief pavmepafii khyagkvkyg
      661 vkdfrekntd hmrpdivall rssknafisg migidpvavf rwailraffr amvafreagk
      721 rnihrktghd dtapcailks mdsfsflqhp vhqrsleilq rckeekysit rknprtplsd
      781 lqgmnalnek nqhdtfdiaw ngrtgirqsr lssgtslldk dgifanstss kllerahgil
      841 trnknfkskp alpkhllevn slkhltrltl qdritksllh lhkkkkppsi saqfqaslsk
      901 lmetlgqaep yfvkcirsna eklplrfsdv lvlrqlrytg mletvrirqs gysskysfqd
      961 fvshfhvllp rniipskfni qdffrkinln pdnyqvgktm vflkeqerqh lqdllhqevl
     1021 rriillqrwf rvllcrqhfl hlrqasviiq rfwrnylnqk qvrdaavqkd afvmasaaal
     1081 lqaswrahle rqrylelraa aiviqqkwrd yyrrrhmaai ciqarwkayr eskryqeqrk
     1141 kiillqstcr gfrarqrfka lkeqrlretk pevglvnikg ygsleiqgsd psgwedcsfd
     1201 nrikaieeck sviesnrisr essvdclkes pnkqqeraqs qsgvdlqedv lvrerprsle
     1261 dlhqkkvgra kresrrmrel eqaifslell kvrslggisp sedrrwstel vpeglqsprg
     1321 tpdsessqgs lellsyeesq ksklesvisd egdlqfpspk issspkfdsr dnalsasnet
     1381 ssaehlkdgt mkemvvcsse sitckpqlkd sfisnslptf fyipqqdplk tnsqldtsiq
     1441 rnkllenedt agealtldin retrryhcsg kdqivpslnt essnpvlkkl eklntekeer
     1501 qkqlqqqnek emmeqirqqt dilekerkaf ktiekprige clvapssyqs kqrverpssl
     1561 lslntsnkge lnvlgslslk daalaqkdss sahlppkdrp vtvfferkgs pcqsstvkel
     1621 sktdrmgtql nvacklsnnr iskrehfrpt qsyshnsddl sregnarpif ftpkdnmsip
     1681 lvskealnsk npqlhkedep awkpvklagp gqretsqrfs svdeqaklhk tmsqgeitkl
     1741 avrqkasdsd irpqrakmrf wakgkqgekk ttrvkpttqs evsplfagtd vipahqfpde
     1801 laayhptppl spelpgscrk efkenkepsp kakrkrsvki snvaldsmhw qndsvqiias
     1861 vsdlksmdef llkkvndldn edskkdtlvd vvfkkalkef rqnifsfyss alamddgksi
     1921 rykdlyalfe qilektmrle qrdslgespv rvwvntfkvf ldeymnefkt sdctatkvpk
     1981 terkkrrkke tdlveehngh ifkatqysip tyceycssli wimdrasvck lckyachkkc
     2041 clkttakcsk kydpelssrq fgvelsrlts edrtvplvve klinyiemhg lytegiyrks
     2101 gstnkikelr qgldtdaesv nlddynihvi asvfkqwlrd lpnplmtfel yeeflramgl
     2161 qerketirgv ysvidqlsrt hlntlerlif hlvrialqed tnrmsanala ivfapcilrc
     2221 pdttdplqsv qdisktttcv elivveqmnk ykarlkdiss lefaenkakt rlslirrsmk
     2281 pvliavrfmn itrnsvsgkg rirrgnypgp sspvvvrlps vsdvseetlt seaametdit
     2341 eqqqaamqqe ervlteqien lqkekeeltf emlvlepras ddetleseas igtadssenl
     2401 nmeseyaise kserslalss lktagkseps sklrkqlkkq qdsldvvdss vsslclsnta
     2461 sshgtrklfq iyskspfyra asgnealgme gplgqtkfle dkpqfisrgt fnpekgkqkl
     2521 knvknspqkt ketpegtvms grrktvdpdc tsnqqlalfg nnefmv
//
LOCUS       XP_047288533            2560 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-IXa isoform X15 [Homo sapiens].
ACCESSION   XP_047288533
VERSION     XP_047288533.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432577.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2560
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2560
                     /product="unconventional myosin-IXa isoform X15"
                     /calculated_mol_wt=293306
     Region          15..110
                     /region_name="RA_Myosin-IXa"
                     /note="Ras-associating (RA) domain found in Myosin-IXa;
                     cd17216"
                     /db_xref="CDD:340736"
     Region          160..945
                     /region_name="MYSc_Myo9"
                     /note="class IX myosin, motor domain; cd01385"
                     /db_xref="CDD:276836"
     Site            order(187..195,239..246,285..295,518..523)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276836"
     Site            187..195
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276836"
     Site            239..246
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276836"
     Site            285..295
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276836"
     Site            461
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:276836"
     Site            518..523
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276836"
     Site            order(547..558,561..570)
                     /site_type="active"
                     /note="relay loop [active]"
                     /db_xref="CDD:276836"
     Site            881..890
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276836"
     Site            order(893..920,924..945)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276836"
     Region          2007..2064
                     /region_name="C1_Myosin-IXa"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in unconventional myosin-IXa and similar proteins;
                     cd20883"
                     /db_xref="CDD:410433"
     Region          2073..2258
                     /region_name="RhoGAP_myosin_IX"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain present in class IX myosins. Class
                     IX myosins contain a characteristic head domain, a neck
                     domain, a tail domain which contains a C6H2-zinc binding
                     motif and a RhoGAP domain. Class...; cd04377"
                     /db_xref="CDD:239842"
     Site            order(2110,2147,2151,2220,2223..2224,2249)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239842"
     Site            2110
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239842"
     CDS             1..2560
                     /gene="MYO9A"
                     /gene_synonym="CMS24"
                     /coded_by="XM_047432577.1:543..8225"
                     /db_xref="GeneID:4649"
                     /db_xref="HGNC:HGNC:7608"
                     /db_xref="MIM:604875"
ORIGIN      
        1 mnindggrrr fednehtlri ypgaisegti ycpiparkns taaeviesli nklhldktkc
       61 yvlaevkefg geewilnptd cpvqrmmlwp rmalenrlsg edyrfllrek nldgsihygs
      121 lqswlrvtee rrrmmergfl pqpqqkdfdd lcslpdlnek tllenlrnrf khekiytyvg
      181 silivinpfk flpiynpkyv kmydnhqlgk lephiyavad vayhamlqrk knqcivisge
      241 sgsgktqstn flihhltals qkgfasgveq iilgagpvle afgnaktahn nnssrfgkfi
      301 qvnyqetgtv lgayvekyll eksrlvyqeh nernyhvfyy llagaseder safhlkqpee
      361 yhylnqdcft vegedlrhdf erlqlamemv gflpktrrqi fsllsailhl gnicykkkty
      421 rddsidicnp evlpivsell evkeemlfea lvtrktvtvg eklilpykla eavtvrnsma
      481 kslysalfdw ivfrinhall nskdlehntk tlsigvldif gfedyennsf eqfcinfane
      541 rlqhyfnqhi fkleqeeyrt egiswhnidy idntccinli skkptgllhl ldeesnfpqa
      601 tnqtlldkfk hqhednsyie fpavmepafi ikhyagkvky gvkdfreknt dhmrpdival
      661 lrssknafis gmigidpvav frwailraff ramvafreag krnihrktgi trknprtpls
      721 dlqgmnalne knqhdtfdia wngrtgirqs rlssgtslld kdgifansts skllerahgi
      781 ltrnknfksk palpkhllev nslkhltrlt lqdritksll hlhkkkkpps isaqfqasls
      841 klmetlgqae pyfvkcirsn aeklplrfsd vlvlrqlryt gmletvrirq sgysskysfq
      901 dfvshfhvll prniipskfn iqdffrkinl npdnyqvgkt mvflkeqerq hlqdllhqev
      961 lrriillqrw frvllcrqhf lhlrqasvii qrfwrnylnq kqvrdaavqk dafvmasaaa
     1021 llqaswrahl erqrylelra aaiviqqkwr dyyrrrhmaa iciqarwkay reskryqeqr
     1081 kkiillqstc rgfrarqrfk alkeqrlret kpevglvnik gygsleiqgs dpsgwedcsf
     1141 dnrikaieec ksviesnris ressvdclke spnkqqeraq sqsgvdlqed vlvrerprsl
     1201 edlhqkkvgr akresrrmre leqaifslel lkvrslggis psedrrwste lvpeglqspr
     1261 gtpdsessqg slellsyees qksklesvis degdlqfpsp kissspkfds rdnalsasne
     1321 tssaehlkdg tmkemvvcss esitckpqlk dsfisnslpt ffyipqqdpl ktnsqldtsi
     1381 qrnkllened tagealtldi nretrryhcs gkdqivpsln tessnpvlkk leklntekee
     1441 rqkqlqqqne kemmeqirqq tdilekerka fktiekprig eclvapssyq skqrverpss
     1501 llslntsnkg elnvlgslsl kdaalaqkds ssahlppkdr pvtvfferkg spcqsstvke
     1561 lsktdrmgtq lnvacklsnn riskrehfrp tqsyshnsdd lsregnarpi fftpkdnmsi
     1621 plvskealns knpqlhkede pawkpvklag pgqrevarpa hkkkarmart rsdfltrgtf
     1681 adgegdteed dyddiiepll sldqashcel gpapslgqas hsdsemtsqr fssvdeqakl
     1741 hktmsqgeit klavrqkasd sdirpqrakm rfwakgkqge kkttrvkptt qsevsplfag
     1801 tdvipahqfp delaayhptp plspelpgsc rkefkenkep spkakrkrsv kisnvaldsm
     1861 hwqndsvqii asvsdlksmd efllkkvndl dnedskkdtl vdvvfkkalk efrqnifsfy
     1921 ssalamddgk sirykdlyal feqilektmr leqrdslges pvrvwvntfk vfldeymnef
     1981 ktsdctatkv pkterkkrrk ketdlveehn ghifkatqys iptyceycss liwimdrasv
     2041 cklckyachk kcclkttakc skkydpelss rqfgvelsrl tsedrtvplv veklinyiem
     2101 hglytegiyr ksgstnkike lrqgldtdae svnlddynih viasvfkqwl rdlpnplmtf
     2161 elyeeflram glqerketir gvysvidqls rthlntlerl ifhlvrialq edtnrmsana
     2221 laivfapcil rcpdttdplq svqdiskttt cvelivveqm nkykarlkdi sslefaenka
     2281 ktrlslirrs mgkgrirrgn ypgpsspvvv rlpsvsdvse etltseaame tditeqqqaa
     2341 mqqeervlte qienlqkeke eltfemlvle prasddetle seasigtads senlnmesey
     2401 aiseksersl alsslktagk sepssklrkq lkkqqdsldv vdssvsslcl sntasshgtr
     2461 klfqiysksp fyraasgnea lgmegplgqt kfledkpqfi srgtfnpekg kqklknvkns
     2521 pqktketpeg tvmsgrrktv dpdctsnqql alfgnnefmv
//
LOCUS       XP_047288534            2548 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-IXa isoform X16 [Homo sapiens].
ACCESSION   XP_047288534
VERSION     XP_047288534.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432578.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2548
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2548
                     /product="unconventional myosin-IXa isoform X16"
                     /calculated_mol_wt=292576
     Region          15..110
                     /region_name="RA_Myosin-IXa"
                     /note="Ras-associating (RA) domain found in Myosin-IXa;
                     cd17216"
                     /db_xref="CDD:340736"
     Region          160..1004
                     /region_name="MYSc_Myo9"
                     /note="class IX myosin, motor domain; cd01385"
                     /db_xref="CDD:276836"
     Site            order(187..195,239..246,285..295,537..542)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276836"
     Site            187..195
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276836"
     Site            239..246
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276836"
     Site            285..295
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276836"
     Site            480
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:276836"
     Site            537..542
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276836"
     Site            order(566..577,580..589)
                     /site_type="active"
                     /note="relay loop [active]"
                     /db_xref="CDD:276836"
     Site            940..949
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276836"
     Site            order(952..979,983..1004)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276836"
     Region          1995..2052
                     /region_name="C1_Myosin-IXa"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in unconventional myosin-IXa and similar proteins;
                     cd20883"
                     /db_xref="CDD:410433"
     Region          2061..2246
                     /region_name="RhoGAP_myosin_IX"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain present in class IX myosins. Class
                     IX myosins contain a characteristic head domain, a neck
                     domain, a tail domain which contains a C6H2-zinc binding
                     motif and a RhoGAP domain. Class...; cd04377"
                     /db_xref="CDD:239842"
     Site            order(2098,2135,2139,2208,2211..2212,2237)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239842"
     Site            2098
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239842"
     CDS             1..2548
                     /gene="MYO9A"
                     /gene_synonym="CMS24"
                     /coded_by="XM_047432578.1:346..7992"
                     /db_xref="GeneID:4649"
                     /db_xref="HGNC:HGNC:7608"
                     /db_xref="MIM:604875"
ORIGIN      
        1 mnindggrrr fednehtlri ypgaisegti ycpiparkns taaeviesli nklhldktkc
       61 yvlaevkefg geewilnptd cpvqrmmlwp rmalenrlsg edyrfllrek nldgsihygs
      121 lqswlrvtee rrrmmergfl pqpqqkdfdd lcslpdlnek tllenlrnrf khekiytyvg
      181 silivinpfk flpiynpkyv kmydnhqlgk lephiyavad vayhamlqrk knqcivisge
      241 sgsgktqstn flihhltals qkgfasgveq iilgagpvle afgnaktahn nnssrfgkfi
      301 qvnyqetgtv lgayvekyll eksrlvyqeh nernyhvfyy llagaseder safhlkqpee
      361 yhylnqitkk plrqswddyc ydsepdcftv egedlrhdfe rlqlamemvg flpktrrqif
      421 sllsailhlg nicykkktyr ddsidicnpe vlpivselle vkeemlfeal vtrktvtvge
      481 klilpyklae avtvrnsmak slysalfdwi vfrinhalln skdlehntkt lsigvldifg
      541 fedyennsfe qfcinfaner lqhyfnqhif kleqeeyrte giswhnidyi dntccinlis
      601 kkptgllhll deesnfpqat nqtlldkfkh qhednsyief pavmepafii khyagkvkyg
      661 vkdfrekntd hmrpdivall rssknafisg migidpvavf rwailraffr amvafreagk
      721 rnihrktghd dtapcailks mdsfsflqhp vhqrsleilq rckeekysit rknprtplsd
      781 lqgmnalnek nqhdtfdiaw ngrtgirqsr lssgtslldk dgifanstss kllerahgil
      841 trnknfkskp alpkhllevn slkhltrltl qdritksllh lhkkkkppsi saqfqaslsk
      901 lmetlgqaep yfvkcirsna eklplrfsdv lvlrqlrytg mletvrirqs gysskysfqd
      961 fvshfhvllp rniipskfni qdffrkinln pdnyqvgktm vflkeqerqh lqdllhqevl
     1021 rriillqrwf rvllcrqhfl hlrqasviiq rfwrnylnqk qvrdaavqkd afvmasaaal
     1081 lqaswrahle rqrylelraa aiviqqkwrd yyrrrhmaai ciqarwkayr eskryqeqrk
     1141 kiillqstcr gfrarqrfka lkeqrlretk pevglvnikg ygsleiqgsd psgwedcsfd
     1201 nrikaieeck sviesnrisr essvdclkes pnkqqeraqs qsgvdlqedv lvrerprsle
     1261 dlhqkkvgra kresrrmrel eqaifslell kvrslggisp sedrrwstel vpeglqsprg
     1321 tpdsessqgs lellsyeesq ksklesvisd egdlqfpspk issspkfdsr dnalsasnet
     1381 ssaehlkdgt mkemvvcsse sitckpqlkd sfisnslptf fyipqqdplk tnsqldtsiq
     1441 rnkllenedt agealtldin retrryhcsg kdqivpslnt essnpvlkkl eklntekeer
     1501 qkqlqqqnek emmeqirqqt dilekerkaf ktiekprige clvapssyqs kqrverpssl
     1561 lslntsnkge lnvlgslslk daalaqkdss sahlppkdrp vtvfferkgs pcqsstvkel
     1621 sktdrmgtql nvacklsnnr iskrehfrpt qsyshnsddl sregnarpif ftpkdnmsip
     1681 lvskealnsk npqlhkedep awkpvklagp gqretsqrfs svdeqaklhk tmsqgeitkl
     1741 avrqkasdsd irpqrakmrf wakgkqgekk ttrvkpttqs evsplfagtd vipahqfpde
     1801 laayhptppl spelpgscrk efkenkepsp kakrkrsvki snvaldsmhw qndsvqiias
     1861 vsdlksmdef llkkvndldn edskkdtlvd vvfkkalkef rqnifsfyss alamddgksi
     1921 rykdlyalfe qilektmrle qrdslgespv rvwvntfkvf ldeymnefkt sdctatkvpk
     1981 terkkrrkke tdlveehngh ifkatqysip tyceycssli wimdrasvck lckyachkkc
     2041 clkttakcsk kydpelssrq fgvelsrlts edrtvplvve klinyiemhg lytegiyrks
     2101 gstnkikelr qgldtdaesv nlddynihvi asvfkqwlrd lpnplmtfel yeeflramgl
     2161 qerketirgv ysvidqlsrt hlntlerlif hlvrialqed tnrmsanala ivfapcilrc
     2221 pdttdplqsv qdisktttcv elivveqmnk ykarlkdiss lefaenkakt rlslirrsmg
     2281 kgrirrgnyp gpsspvvvrl psvsdvseet ltseaametd iteqqqaamq qeervlteqi
     2341 enlqkekeel tfemlvlepr asddetlese asigtadsse nlnmeseyai sekserslal
     2401 sslktagkse pssklrkqlk kqqdsldvvd ssvsslclsn tasshgtrkl fqiyskspfy
     2461 raasgnealg megplgqtkf ledkpqfisr gtfnpekgkq klknvknspq ktketpegtv
     2521 msgrrktvdp dctsnqqlal fgnnefmv
//
LOCUS       XP_016877719            2547 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-IXa isoform X17 [Homo sapiens].
ACCESSION   XP_016877719
VERSION     XP_016877719.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022230.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2547
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2547
                     /product="unconventional myosin-IXa isoform X17"
                     /calculated_mol_wt=292277
     Region          15..110
                     /region_name="RA_Myosin-IXa"
                     /note="Ras-associating (RA) domain found in Myosin-IXa;
                     cd17216"
                     /db_xref="CDD:340736"
     Region          160..985
                     /region_name="MYSc_Myo9"
                     /note="class IX myosin, motor domain; cd01385"
                     /db_xref="CDD:276836"
     Site            order(187..195,239..246,285..295,518..523)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276836"
     Site            187..195
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276836"
     Site            239..246
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276836"
     Site            285..295
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276836"
     Site            461
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:276836"
     Site            518..523
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276836"
     Site            order(547..558,561..570)
                     /site_type="active"
                     /note="relay loop [active]"
                     /db_xref="CDD:276836"
     Site            921..930
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276836"
     Site            order(933..960,964..985)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276836"
     Region          1976..2033
                     /region_name="C1_Myosin-IXa"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in unconventional myosin-IXa and similar proteins;
                     cd20883"
                     /db_xref="CDD:410433"
     Region          2042..2227
                     /region_name="RhoGAP_myosin_IX"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain present in class IX myosins. Class
                     IX myosins contain a characteristic head domain, a neck
                     domain, a tail domain which contains a C6H2-zinc binding
                     motif and a RhoGAP domain. Class...; cd04377"
                     /db_xref="CDD:239842"
     Site            order(2079,2116,2120,2189,2192..2193,2218)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239842"
     Site            2079
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239842"
     CDS             1..2547
                     /gene="MYO9A"
                     /gene_synonym="CMS24"
                     /coded_by="XM_017022230.3:543..8186"
                     /db_xref="GeneID:4649"
                     /db_xref="HGNC:HGNC:7608"
                     /db_xref="MIM:604875"
ORIGIN      
        1 mnindggrrr fednehtlri ypgaisegti ycpiparkns taaeviesli nklhldktkc
       61 yvlaevkefg geewilnptd cpvqrmmlwp rmalenrlsg edyrfllrek nldgsihygs
      121 lqswlrvtee rrrmmergfl pqpqqkdfdd lcslpdlnek tllenlrnrf khekiytyvg
      181 silivinpfk flpiynpkyv kmydnhqlgk lephiyavad vayhamlqrk knqcivisge
      241 sgsgktqstn flihhltals qkgfasgveq iilgagpvle afgnaktahn nnssrfgkfi
      301 qvnyqetgtv lgayvekyll eksrlvyqeh nernyhvfyy llagaseder safhlkqpee
      361 yhylnqdcft vegedlrhdf erlqlamemv gflpktrrqi fsllsailhl gnicykkkty
      421 rddsidicnp evlpivsell evkeemlfea lvtrktvtvg eklilpykla eavtvrnsma
      481 kslysalfdw ivfrinhall nskdlehntk tlsigvldif gfedyennsf eqfcinfane
      541 rlqhyfnqhi fkleqeeyrt egiswhnidy idntccinli skkptgllhl ldeesnfpqa
      601 tnqtlldkfk hqhednsyie fpavmepafi ikhyagkvky gvkdfreknt dhmrpdival
      661 lrssknafis gmigidpvav frwailraff ramvafreag krnihrktgh ddtapcailk
      721 smdsfsflqh pvhqrsleil qrckeekysi trknprtpls dlqgmnalne knqhdtfdia
      781 wngrtgirqs rlssgtslld kdgifansts skllerahgi ltrnknfksk palpkhllev
      841 nslkhltrlt lqdritksll hlhkkkkpps isaqfqasls klmetlgqae pyfvkcirsn
      901 aeklplrfsd vlvlrqlryt gmletvrirq sgysskysfq dfvshfhvll prniipskfn
      961 iqdffrkinl npdnyqvgkt mvflkeqerq hlqdllhqev lrriillqrw frvllcrqhf
     1021 lhlrqasvii qrfwrnylnq kqvrdaavqk dafvmasaaa llqaswrahl erqrylelra
     1081 aaiviqqkwr dyyrrrhmaa iciqarwkay reskryqeqr kkiillqstc rgfrarqrfk
     1141 alkeqrlret kpevglvnik gygsleiqgs dpsgwedcsf dnrikaieec ksviesnris
     1201 ressvdclke spnkqqeraq sqsgvdlqed vlvrerprsl edlhqkkvgr akresrrmre
     1261 leqaifslel lkvrslggis psedrrwste lvpeglqspr gtpdsessqg slellsyees
     1321 qksklesvis degdlqfpsp kissspkfds rdnalsasne tssaehlkdg tmkemvvcss
     1381 esitckpqlk dsfisnslpt ffyipqqdpl ktnsqldtsi qrnkllened tagealtldi
     1441 nretrryhcs gkdqivpsln tessnpvlkk leklntekee rqkqlqqqne kemmeqirqq
     1501 tdilekerka fktiekprig eclvapssyq skqrverpss llslntsnkg elnvlgslsl
     1561 kdaalaqkds ssahlppkdr pvtvfferkg spcqsstvke lsktdrmgtq lnvacklsnn
     1621 riskrehfrp tqsyshnsdd lsregnarpi fftpkdnmsi plvskealns knpqlhkede
     1681 pawkpvklag pgqretsqrf ssvdeqaklh ktmsqgeitk lavrqkasds dirpqrakmr
     1741 fwakgkqgek kttrvkpttq sevsplfagt dvipahqfpd elaayhptpp lspelpgscr
     1801 kefkenkeps pkakrkrsvk isnvaldsmh wqndsvqiia svsdlksmde fllkkvndld
     1861 nedskkdtlv dvvfkkalke frqnifsfys salamddgks irykdlyalf eqilektmrl
     1921 eqrdslgesp vrvwvntfkv fldeymnefk tsdctatkvp kterkkrrkk etdlveehng
     1981 hifkatqysi ptyceycssl iwimdrasvc klckyachkk cclkttakcs kkydpelssr
     2041 qfgvelsrlt sedrtvplvv eklinyiemh glytegiyrk sgstnkikel rqgldtdaes
     2101 vnlddynihv iasvfkqwlr dlpnplmtfe lyeeflramg lqerketirg vysvidqlsr
     2161 thlntlerli fhlvrialqe dtnrmsanal aivfapcilr cpdttdplqs vqdisktttc
     2221 velivveqmn kykarlkdis slefaenkak trlslirrsm kpvliavrfm nitrnsvsgk
     2281 grirrgnypg psspvvvrlp svsdvseetl tseaametdi teqqqaamqq eervlteqie
     2341 nlqkekeelt femlvlepra sddetlesea sigtadssen lnmeseyais ekserslals
     2401 slktagksep ssklrkqlkk qqdsldvvds svsslclsnt asshgtrklf qiyskspfyr
     2461 aasgnealgm egplgqtkfl edkpqfisrg tfnpekgkqk lknvknspqk tketpegtvm
     2521 sgrrktvdpd ctsnqqlalf gnnefmv
//
LOCUS       XP_047288535            2547 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-IXa isoform X17 [Homo sapiens].
ACCESSION   XP_047288535
VERSION     XP_047288535.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432579.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2547
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2547
                     /product="unconventional myosin-IXa isoform X17"
                     /calculated_mol_wt=292277
     Region          15..110
                     /region_name="RA_Myosin-IXa"
                     /note="Ras-associating (RA) domain found in Myosin-IXa;
                     cd17216"
                     /db_xref="CDD:340736"
     Region          160..985
                     /region_name="MYSc_Myo9"
                     /note="class IX myosin, motor domain; cd01385"
                     /db_xref="CDD:276836"
     Site            order(187..195,239..246,285..295,518..523)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276836"
     Site            187..195
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276836"
     Site            239..246
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276836"
     Site            285..295
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276836"
     Site            461
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:276836"
     Site            518..523
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276836"
     Site            order(547..558,561..570)
                     /site_type="active"
                     /note="relay loop [active]"
                     /db_xref="CDD:276836"
     Site            921..930
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276836"
     Site            order(933..960,964..985)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276836"
     Region          1976..2033
                     /region_name="C1_Myosin-IXa"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in unconventional myosin-IXa and similar proteins;
                     cd20883"
                     /db_xref="CDD:410433"
     Region          2042..2227
                     /region_name="RhoGAP_myosin_IX"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain present in class IX myosins. Class
                     IX myosins contain a characteristic head domain, a neck
                     domain, a tail domain which contains a C6H2-zinc binding
                     motif and a RhoGAP domain. Class...; cd04377"
                     /db_xref="CDD:239842"
     Site            order(2079,2116,2120,2189,2192..2193,2218)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239842"
     Site            2079
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239842"
     CDS             1..2547
                     /gene="MYO9A"
                     /gene_synonym="CMS24"
                     /coded_by="XM_047432579.1:588..8231"
                     /db_xref="GeneID:4649"
                     /db_xref="HGNC:HGNC:7608"
                     /db_xref="MIM:604875"
ORIGIN      
        1 mnindggrrr fednehtlri ypgaisegti ycpiparkns taaeviesli nklhldktkc
       61 yvlaevkefg geewilnptd cpvqrmmlwp rmalenrlsg edyrfllrek nldgsihygs
      121 lqswlrvtee rrrmmergfl pqpqqkdfdd lcslpdlnek tllenlrnrf khekiytyvg
      181 silivinpfk flpiynpkyv kmydnhqlgk lephiyavad vayhamlqrk knqcivisge
      241 sgsgktqstn flihhltals qkgfasgveq iilgagpvle afgnaktahn nnssrfgkfi
      301 qvnyqetgtv lgayvekyll eksrlvyqeh nernyhvfyy llagaseder safhlkqpee
      361 yhylnqdcft vegedlrhdf erlqlamemv gflpktrrqi fsllsailhl gnicykkkty
      421 rddsidicnp evlpivsell evkeemlfea lvtrktvtvg eklilpykla eavtvrnsma
      481 kslysalfdw ivfrinhall nskdlehntk tlsigvldif gfedyennsf eqfcinfane
      541 rlqhyfnqhi fkleqeeyrt egiswhnidy idntccinli skkptgllhl ldeesnfpqa
      601 tnqtlldkfk hqhednsyie fpavmepafi ikhyagkvky gvkdfreknt dhmrpdival
      661 lrssknafis gmigidpvav frwailraff ramvafreag krnihrktgh ddtapcailk
      721 smdsfsflqh pvhqrsleil qrckeekysi trknprtpls dlqgmnalne knqhdtfdia
      781 wngrtgirqs rlssgtslld kdgifansts skllerahgi ltrnknfksk palpkhllev
      841 nslkhltrlt lqdritksll hlhkkkkpps isaqfqasls klmetlgqae pyfvkcirsn
      901 aeklplrfsd vlvlrqlryt gmletvrirq sgysskysfq dfvshfhvll prniipskfn
      961 iqdffrkinl npdnyqvgkt mvflkeqerq hlqdllhqev lrriillqrw frvllcrqhf
     1021 lhlrqasvii qrfwrnylnq kqvrdaavqk dafvmasaaa llqaswrahl erqrylelra
     1081 aaiviqqkwr dyyrrrhmaa iciqarwkay reskryqeqr kkiillqstc rgfrarqrfk
     1141 alkeqrlret kpevglvnik gygsleiqgs dpsgwedcsf dnrikaieec ksviesnris
     1201 ressvdclke spnkqqeraq sqsgvdlqed vlvrerprsl edlhqkkvgr akresrrmre
     1261 leqaifslel lkvrslggis psedrrwste lvpeglqspr gtpdsessqg slellsyees
     1321 qksklesvis degdlqfpsp kissspkfds rdnalsasne tssaehlkdg tmkemvvcss
     1381 esitckpqlk dsfisnslpt ffyipqqdpl ktnsqldtsi qrnkllened tagealtldi
     1441 nretrryhcs gkdqivpsln tessnpvlkk leklntekee rqkqlqqqne kemmeqirqq
     1501 tdilekerka fktiekprig eclvapssyq skqrverpss llslntsnkg elnvlgslsl
     1561 kdaalaqkds ssahlppkdr pvtvfferkg spcqsstvke lsktdrmgtq lnvacklsnn
     1621 riskrehfrp tqsyshnsdd lsregnarpi fftpkdnmsi plvskealns knpqlhkede
     1681 pawkpvklag pgqretsqrf ssvdeqaklh ktmsqgeitk lavrqkasds dirpqrakmr
     1741 fwakgkqgek kttrvkpttq sevsplfagt dvipahqfpd elaayhptpp lspelpgscr
     1801 kefkenkeps pkakrkrsvk isnvaldsmh wqndsvqiia svsdlksmde fllkkvndld
     1861 nedskkdtlv dvvfkkalke frqnifsfys salamddgks irykdlyalf eqilektmrl
     1921 eqrdslgesp vrvwvntfkv fldeymnefk tsdctatkvp kterkkrrkk etdlveehng
     1981 hifkatqysi ptyceycssl iwimdrasvc klckyachkk cclkttakcs kkydpelssr
     2041 qfgvelsrlt sedrtvplvv eklinyiemh glytegiyrk sgstnkikel rqgldtdaes
     2101 vnlddynihv iasvfkqwlr dlpnplmtfe lyeeflramg lqerketirg vysvidqlsr
     2161 thlntlerli fhlvrialqe dtnrmsanal aivfapcilr cpdttdplqs vqdisktttc
     2221 velivveqmn kykarlkdis slefaenkak trlslirrsm kpvliavrfm nitrnsvsgk
     2281 grirrgnypg psspvvvrlp svsdvseetl tseaametdi teqqqaamqq eervlteqie
     2341 nlqkekeelt femlvlepra sddetlesea sigtadssen lnmeseyais ekserslals
     2401 slktagksep ssklrkqlkk qqdsldvvds svsslclsnt asshgtrklf qiyskspfyr
     2461 aasgnealgm egplgqtkfl edkpqfisrg tfnpekgkqk lknvknspqk tketpegtvm
     2521 sgrrktvdpd ctsnqqlalf gnnefmv
//
LOCUS       XP_047288536            2547 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-IXa isoform X17 [Homo sapiens].
ACCESSION   XP_047288536
VERSION     XP_047288536.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432580.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2547
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2547
                     /product="unconventional myosin-IXa isoform X17"
                     /calculated_mol_wt=292277
     Region          15..110
                     /region_name="RA_Myosin-IXa"
                     /note="Ras-associating (RA) domain found in Myosin-IXa;
                     cd17216"
                     /db_xref="CDD:340736"
     Region          160..985
                     /region_name="MYSc_Myo9"
                     /note="class IX myosin, motor domain; cd01385"
                     /db_xref="CDD:276836"
     Site            order(187..195,239..246,285..295,518..523)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276836"
     Site            187..195
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276836"
     Site            239..246
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276836"
     Site            285..295
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276836"
     Site            461
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:276836"
     Site            518..523
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276836"
     Site            order(547..558,561..570)
                     /site_type="active"
                     /note="relay loop [active]"
                     /db_xref="CDD:276836"
     Site            921..930
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276836"
     Site            order(933..960,964..985)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276836"
     Region          1976..2033
                     /region_name="C1_Myosin-IXa"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in unconventional myosin-IXa and similar proteins;
                     cd20883"
                     /db_xref="CDD:410433"
     Region          2042..2227
                     /region_name="RhoGAP_myosin_IX"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain present in class IX myosins. Class
                     IX myosins contain a characteristic head domain, a neck
                     domain, a tail domain which contains a C6H2-zinc binding
                     motif and a RhoGAP domain. Class...; cd04377"
                     /db_xref="CDD:239842"
     Site            order(2079,2116,2120,2189,2192..2193,2218)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239842"
     Site            2079
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239842"
     CDS             1..2547
                     /gene="MYO9A"
                     /gene_synonym="CMS24"
                     /coded_by="XM_047432580.1:140..7783"
                     /db_xref="GeneID:4649"
                     /db_xref="HGNC:HGNC:7608"
                     /db_xref="MIM:604875"
ORIGIN      
        1 mnindggrrr fednehtlri ypgaisegti ycpiparkns taaeviesli nklhldktkc
       61 yvlaevkefg geewilnptd cpvqrmmlwp rmalenrlsg edyrfllrek nldgsihygs
      121 lqswlrvtee rrrmmergfl pqpqqkdfdd lcslpdlnek tllenlrnrf khekiytyvg
      181 silivinpfk flpiynpkyv kmydnhqlgk lephiyavad vayhamlqrk knqcivisge
      241 sgsgktqstn flihhltals qkgfasgveq iilgagpvle afgnaktahn nnssrfgkfi
      301 qvnyqetgtv lgayvekyll eksrlvyqeh nernyhvfyy llagaseder safhlkqpee
      361 yhylnqdcft vegedlrhdf erlqlamemv gflpktrrqi fsllsailhl gnicykkkty
      421 rddsidicnp evlpivsell evkeemlfea lvtrktvtvg eklilpykla eavtvrnsma
      481 kslysalfdw ivfrinhall nskdlehntk tlsigvldif gfedyennsf eqfcinfane
      541 rlqhyfnqhi fkleqeeyrt egiswhnidy idntccinli skkptgllhl ldeesnfpqa
      601 tnqtlldkfk hqhednsyie fpavmepafi ikhyagkvky gvkdfreknt dhmrpdival
      661 lrssknafis gmigidpvav frwailraff ramvafreag krnihrktgh ddtapcailk
      721 smdsfsflqh pvhqrsleil qrckeekysi trknprtpls dlqgmnalne knqhdtfdia
      781 wngrtgirqs rlssgtslld kdgifansts skllerahgi ltrnknfksk palpkhllev
      841 nslkhltrlt lqdritksll hlhkkkkpps isaqfqasls klmetlgqae pyfvkcirsn
      901 aeklplrfsd vlvlrqlryt gmletvrirq sgysskysfq dfvshfhvll prniipskfn
      961 iqdffrkinl npdnyqvgkt mvflkeqerq hlqdllhqev lrriillqrw frvllcrqhf
     1021 lhlrqasvii qrfwrnylnq kqvrdaavqk dafvmasaaa llqaswrahl erqrylelra
     1081 aaiviqqkwr dyyrrrhmaa iciqarwkay reskryqeqr kkiillqstc rgfrarqrfk
     1141 alkeqrlret kpevglvnik gygsleiqgs dpsgwedcsf dnrikaieec ksviesnris
     1201 ressvdclke spnkqqeraq sqsgvdlqed vlvrerprsl edlhqkkvgr akresrrmre
     1261 leqaifslel lkvrslggis psedrrwste lvpeglqspr gtpdsessqg slellsyees
     1321 qksklesvis degdlqfpsp kissspkfds rdnalsasne tssaehlkdg tmkemvvcss
     1381 esitckpqlk dsfisnslpt ffyipqqdpl ktnsqldtsi qrnkllened tagealtldi
     1441 nretrryhcs gkdqivpsln tessnpvlkk leklntekee rqkqlqqqne kemmeqirqq
     1501 tdilekerka fktiekprig eclvapssyq skqrverpss llslntsnkg elnvlgslsl
     1561 kdaalaqkds ssahlppkdr pvtvfferkg spcqsstvke lsktdrmgtq lnvacklsnn
     1621 riskrehfrp tqsyshnsdd lsregnarpi fftpkdnmsi plvskealns knpqlhkede
     1681 pawkpvklag pgqretsqrf ssvdeqaklh ktmsqgeitk lavrqkasds dirpqrakmr
     1741 fwakgkqgek kttrvkpttq sevsplfagt dvipahqfpd elaayhptpp lspelpgscr
     1801 kefkenkeps pkakrkrsvk isnvaldsmh wqndsvqiia svsdlksmde fllkkvndld
     1861 nedskkdtlv dvvfkkalke frqnifsfys salamddgks irykdlyalf eqilektmrl
     1921 eqrdslgesp vrvwvntfkv fldeymnefk tsdctatkvp kterkkrrkk etdlveehng
     1981 hifkatqysi ptyceycssl iwimdrasvc klckyachkk cclkttakcs kkydpelssr
     2041 qfgvelsrlt sedrtvplvv eklinyiemh glytegiyrk sgstnkikel rqgldtdaes
     2101 vnlddynihv iasvfkqwlr dlpnplmtfe lyeeflramg lqerketirg vysvidqlsr
     2161 thlntlerli fhlvrialqe dtnrmsanal aivfapcilr cpdttdplqs vqdisktttc
     2221 velivveqmn kykarlkdis slefaenkak trlslirrsm kpvliavrfm nitrnsvsgk
     2281 grirrgnypg psspvvvrlp svsdvseetl tseaametdi teqqqaamqq eervlteqie
     2341 nlqkekeelt femlvlepra sddetlesea sigtadssen lnmeseyais ekserslals
     2401 slktagksep ssklrkqlkk qqdsldvvds svsslclsnt asshgtrklf qiyskspfyr
     2461 aasgnealgm egplgqtkfl edkpqfisrg tfnpekgkqk lknvknspqk tketpegtvm
     2521 sgrrktvdpd ctsnqqlalf gnnefmv
//
LOCUS       XP_047288537            2529 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-IXa isoform X18 [Homo sapiens].
ACCESSION   XP_047288537
VERSION     XP_047288537.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432581.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2529
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2529
                     /product="unconventional myosin-IXa isoform X18"
                     /calculated_mol_wt=290249
     Region          15..110
                     /region_name="RA_Myosin-IXa"
                     /note="Ras-associating (RA) domain found in Myosin-IXa;
                     cd17216"
                     /db_xref="CDD:340736"
     Region          160..985
                     /region_name="MYSc_Myo9"
                     /note="class IX myosin, motor domain; cd01385"
                     /db_xref="CDD:276836"
     Site            order(187..195,239..246,285..295,518..523)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276836"
     Site            187..195
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276836"
     Site            239..246
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276836"
     Site            285..295
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276836"
     Site            461
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:276836"
     Site            518..523
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276836"
     Site            order(547..558,561..570)
                     /site_type="active"
                     /note="relay loop [active]"
                     /db_xref="CDD:276836"
     Site            921..930
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276836"
     Site            order(933..960,964..985)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276836"
     Region          1976..2033
                     /region_name="C1_Myosin-IXa"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in unconventional myosin-IXa and similar proteins;
                     cd20883"
                     /db_xref="CDD:410433"
     Region          2042..2227
                     /region_name="RhoGAP_myosin_IX"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain present in class IX myosins. Class
                     IX myosins contain a characteristic head domain, a neck
                     domain, a tail domain which contains a C6H2-zinc binding
                     motif and a RhoGAP domain. Class...; cd04377"
                     /db_xref="CDD:239842"
     Site            order(2079,2116,2120,2189,2192..2193,2218)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239842"
     Site            2079
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239842"
     CDS             1..2529
                     /gene="MYO9A"
                     /gene_synonym="CMS24"
                     /coded_by="XM_047432581.1:543..8132"
                     /db_xref="GeneID:4649"
                     /db_xref="HGNC:HGNC:7608"
                     /db_xref="MIM:604875"
ORIGIN      
        1 mnindggrrr fednehtlri ypgaisegti ycpiparkns taaeviesli nklhldktkc
       61 yvlaevkefg geewilnptd cpvqrmmlwp rmalenrlsg edyrfllrek nldgsihygs
      121 lqswlrvtee rrrmmergfl pqpqqkdfdd lcslpdlnek tllenlrnrf khekiytyvg
      181 silivinpfk flpiynpkyv kmydnhqlgk lephiyavad vayhamlqrk knqcivisge
      241 sgsgktqstn flihhltals qkgfasgveq iilgagpvle afgnaktahn nnssrfgkfi
      301 qvnyqetgtv lgayvekyll eksrlvyqeh nernyhvfyy llagaseder safhlkqpee
      361 yhylnqdcft vegedlrhdf erlqlamemv gflpktrrqi fsllsailhl gnicykkkty
      421 rddsidicnp evlpivsell evkeemlfea lvtrktvtvg eklilpykla eavtvrnsma
      481 kslysalfdw ivfrinhall nskdlehntk tlsigvldif gfedyennsf eqfcinfane
      541 rlqhyfnqhi fkleqeeyrt egiswhnidy idntccinli skkptgllhl ldeesnfpqa
      601 tnqtlldkfk hqhednsyie fpavmepafi ikhyagkvky gvkdfreknt dhmrpdival
      661 lrssknafis gmigidpvav frwailraff ramvafreag krnihrktgh ddtapcailk
      721 smdsfsflqh pvhqrsleil qrckeekysi trknprtpls dlqgmnalne knqhdtfdia
      781 wngrtgirqs rlssgtslld kdgifansts skllerahgi ltrnknfksk palpkhllev
      841 nslkhltrlt lqdritksll hlhkkkkpps isaqfqasls klmetlgqae pyfvkcirsn
      901 aeklplrfsd vlvlrqlryt gmletvrirq sgysskysfq dfvshfhvll prniipskfn
      961 iqdffrkinl npdnyqvgkt mvflkeqerq hlqdllhqev lrriillqrw frvllcrqhf
     1021 lhlrqasvii qrfwrnylnq kqvrdaavqk dafvmasaaa llqaswrahl erqrylelra
     1081 aaiviqqkwr dyyrrrhmaa iciqarwkay reskryqeqr kkiillqstc rgfrarqrfk
     1141 alkeqrlret kpevglvnik gygsleiqgs dpsgwedcsf dnrikaieec ksviesnris
     1201 ressvdclke spnkqqeraq sqsgvdlqed vlvrerprsl edlhqkkvgr akresrrmre
     1261 leqaifslel lkvrslggis psedrrwste lvpeglqspr gtpdsessqg slellsyees
     1321 qksklesvis degdlqfpsp kissspkfds rdnalsasne tssaehlkdg tmkemvvcss
     1381 esitckpqlk dsfisnslpt ffyipqqdpl ktnsqldtsi qrnkllened tagealtldi
     1441 nretrryhcs gkdqivpsln tessnpvlkk leklntekee rqkqlqqqne kemmeqirqq
     1501 tdilekerka fktiekprig eclvapssyq skqrverpss llslntsnkg elnvlgslsl
     1561 kdaalaqkds ssahlppkdr pvtvfferkg spcqsstvke lsktdrmgtq lnvacklsnn
     1621 riskrehfrp tqsyshnsdd lsregnarpi fftpkdnmsi plvskealns knpqlhkede
     1681 pawkpvklag pgqretsqrf ssvdeqaklh ktmsqgeitk lavrqkasds dirpqrakmr
     1741 fwakgkqgek kttrvkpttq sevsplfagt dvipahqfpd elaayhptpp lspelpgscr
     1801 kefkenkeps pkakrkrsvk isnvaldsmh wqndsvqiia svsdlksmde fllkkvndld
     1861 nedskkdtlv dvvfkkalke frqnifsfys salamddgks irykdlyalf eqilektmrl
     1921 eqrdslgesp vrvwvntfkv fldeymnefk tsdctatkvp kterkkrrkk etdlveehng
     1981 hifkatqysi ptyceycssl iwimdrasvc klckyachkk cclkttakcs kkydpelssr
     2041 qfgvelsrlt sedrtvplvv eklinyiemh glytegiyrk sgstnkikel rqgldtdaes
     2101 vnlddynihv iasvfkqwlr dlpnplmtfe lyeeflramg lqerketirg vysvidqlsr
     2161 thlntlerli fhlvrialqe dtnrmsanal aivfapcilr cpdttdplqs vqdisktttc
     2221 velivveqmn kykarlkdis slefaenkak trlslirrsm gkgrirrgny pgpsspvvvr
     2281 lpsvsdvsee tltseaamet diteqqqaam qqeervlteq ienlqkekee ltfemlvlep
     2341 rasddetles easigtadss enlnmeseya iseksersla lsslktagks epssklrkql
     2401 kkqqdsldvv dssvsslcls ntasshgtrk lfqiyskspf yraasgneal gmegplgqtk
     2461 fledkpqfis rgtfnpekgk qklknvknsp qktketpegt vmsgrrktvd pdctsnqqla
     2521 lfgnnefmv
//
LOCUS       XP_047288539            2526 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-IXa isoform X19 [Homo sapiens].
ACCESSION   XP_047288539
VERSION     XP_047288539.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432583.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2526
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2526
                     /product="unconventional myosin-IXa isoform X19"
                     /calculated_mol_wt=289932
     Region          15..110
                     /region_name="RA_Myosin-IXa"
                     /note="Ras-associating (RA) domain found in Myosin-IXa;
                     cd17216"
                     /db_xref="CDD:340736"
     Region          160..964
                     /region_name="MYSc_Myo9"
                     /note="class IX myosin, motor domain; cd01385"
                     /db_xref="CDD:276836"
     Site            order(187..195,239..246,285..295,537..542)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276836"
     Site            187..195
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276836"
     Site            239..246
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276836"
     Site            285..295
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276836"
     Site            480
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:276836"
     Site            537..542
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276836"
     Site            order(566..577,580..589)
                     /site_type="active"
                     /note="relay loop [active]"
                     /db_xref="CDD:276836"
     Site            900..909
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276836"
     Site            order(912..939,943..964)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276836"
     Region          1955..2012
                     /region_name="C1_Myosin-IXa"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in unconventional myosin-IXa and similar proteins;
                     cd20883"
                     /db_xref="CDD:410433"
     Region          2021..2206
                     /region_name="RhoGAP_myosin_IX"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain present in class IX myosins. Class
                     IX myosins contain a characteristic head domain, a neck
                     domain, a tail domain which contains a C6H2-zinc binding
                     motif and a RhoGAP domain. Class...; cd04377"
                     /db_xref="CDD:239842"
     Site            order(2058,2095,2099,2168,2171..2172,2197)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239842"
     Site            2058
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239842"
     CDS             1..2526
                     /gene="MYO9A"
                     /gene_synonym="CMS24"
                     /coded_by="XM_047432583.1:543..8123"
                     /db_xref="GeneID:4649"
                     /db_xref="HGNC:HGNC:7608"
                     /db_xref="MIM:604875"
ORIGIN      
        1 mnindggrrr fednehtlri ypgaisegti ycpiparkns taaeviesli nklhldktkc
       61 yvlaevkefg geewilnptd cpvqrmmlwp rmalenrlsg edyrfllrek nldgsihygs
      121 lqswlrvtee rrrmmergfl pqpqqkdfdd lcslpdlnek tllenlrnrf khekiytyvg
      181 silivinpfk flpiynpkyv kmydnhqlgk lephiyavad vayhamlqrk knqcivisge
      241 sgsgktqstn flihhltals qkgfasgveq iilgagpvle afgnaktahn nnssrfgkfi
      301 qvnyqetgtv lgayvekyll eksrlvyqeh nernyhvfyy llagaseder safhlkqpee
      361 yhylnqitkk plrqswddyc ydsepdcftv egedlrhdfe rlqlamemvg flpktrrqif
      421 sllsailhlg nicykkktyr ddsidicnpe vlpivselle vkeemlfeal vtrktvtvge
      481 klilpyklae avtvrnsmak slysalfdwi vfrinhalln skdlehntkt lsigvldifg
      541 fedyennsfe qfcinfaner lqhyfnqhif kleqeeyrte giswhnidyi dntccinlis
      601 kkptgllhll deesnfpqat nqtlldkfkh qhednsyief pavmepafii khyagkvkyg
      661 vkdfrekntd hmrpdivall rssknafisg migidpvavf rwailraffr amvafreagk
      721 rnihrktgit rknprtplsd lqgmnalnek nqhdtfdiaw ngrtgirqsr lssgtslldk
      781 dgifanstss kllerahgil trnknfkskp alpkhllevn slkhltrltl qdritksllh
      841 lhkkkkppsi saqfqaslsk lmetlgqaep yfvkcirsna eklplrfsdv lvlrqlrytg
      901 mletvrirqs gysskysfqd fvshfhvllp rniipskfni qdffrkinln pdnyqvgktm
      961 vflkeqerqh lqdllhqevl rriillqrwf rvllcrqhfl hlrqasviiq rfwrnylnqk
     1021 qvrdaavqkd afvmasaaal lqaswrahle rqrylelraa aiviqqkwrd yyrrrhmaai
     1081 ciqarwkayr eskryqeqrk kiillqstcr gfrarqrfka lkeqrlretk pevglvnikg
     1141 ygsleiqgsd psgwedcsfd nrikaieeck sviesnrisr essvdclkes pnkqqeraqs
     1201 qsgvdlqedv lvrerprsle dlhqkkvgra kresrrmrel eqaifslell kvrslggisp
     1261 sedrrwstel vpeglqsprg tpdsessqgs lellsyeesq ksklesvisd egdlqfpspk
     1321 issspkfdsr dnalsasnet ssaehlkdgt mkemvvcsse sitckpqlkd sfisnslptf
     1381 fyipqqdplk tnsqldtsiq rnkllenedt agealtldin retrryhcsg kdqivpslnt
     1441 essnpvlkkl eklntekeer qkqlqqqnek emmeqirqqt dilekerkaf ktiekprige
     1501 clvapssyqs kqrverpssl lslntsnkge lnvlgslslk daalaqkdss sahlppkdrp
     1561 vtvfferkgs pcqsstvkel sktdrmgtql nvacklsnnr iskrehfrpt qsyshnsddl
     1621 sregnarpif ftpkdnmsip lvskealnsk npqlhkedep awkpvklagp gqretsqrfs
     1681 svdeqaklhk tmsqgeitkl avrqkasdsd irpqrakmrf wakgkqgekk ttrvkpttqs
     1741 evsplfagtd vipahqfpde laayhptppl spelpgscrk efkenkepsp kakrkrsvki
     1801 snvaldsmhw qndsvqiias vsdlksmdef llkkvndldn edskkdtlvd vvfkkalkef
     1861 rqnifsfyss alamddgksi rykdlyalfe qilektmrle qrdslgespv rvwvntfkvf
     1921 ldeymnefkt sdctatkvpk terkkrrkke tdlveehngh ifkatqysip tyceycssli
     1981 wimdrasvck lckyachkkc clkttakcsk kydpelssrq fgvelsrlts edrtvplvve
     2041 klinyiemhg lytegiyrks gstnkikelr qgldtdaesv nlddynihvi asvfkqwlrd
     2101 lpnplmtfel yeeflramgl qerketirgv ysvidqlsrt hlntlerlif hlvrialqed
     2161 tnrmsanala ivfapcilrc pdttdplqsv qdisktttcv elivveqmnk ykarlkdiss
     2221 lefaenkakt rlslirrsmk pvliavrfmn itrnsvsgkg rirrgnypgp sspvvvrlps
     2281 vsdvseetlt seaametdit eqqqaamqqe ervlteqien lqkekeeltf emlvlepras
     2341 ddetleseas igtadssenl nmeseyaise kserslalss lktagkseps sklrkqlkkq
     2401 qdsldvvdss vsslclsnta sshgtrklfq iyskspfyra asgnealgme gplgqtkfle
     2461 dkpqfisrgt fnpekgkqkl knvknspqkt ketpegtvms grrktvdpdc tsnqqlalfg
     2521 nnefmv
//
LOCUS       XP_047288540            2526 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-IXa isoform X19 [Homo sapiens].
ACCESSION   XP_047288540
VERSION     XP_047288540.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432584.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2526
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2526
                     /product="unconventional myosin-IXa isoform X19"
                     /calculated_mol_wt=289932
     Region          15..110
                     /region_name="RA_Myosin-IXa"
                     /note="Ras-associating (RA) domain found in Myosin-IXa;
                     cd17216"
                     /db_xref="CDD:340736"
     Region          160..964
                     /region_name="MYSc_Myo9"
                     /note="class IX myosin, motor domain; cd01385"
                     /db_xref="CDD:276836"
     Site            order(187..195,239..246,285..295,537..542)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276836"
     Site            187..195
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276836"
     Site            239..246
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276836"
     Site            285..295
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276836"
     Site            480
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:276836"
     Site            537..542
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276836"
     Site            order(566..577,580..589)
                     /site_type="active"
                     /note="relay loop [active]"
                     /db_xref="CDD:276836"
     Site            900..909
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276836"
     Site            order(912..939,943..964)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276836"
     Region          1955..2012
                     /region_name="C1_Myosin-IXa"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in unconventional myosin-IXa and similar proteins;
                     cd20883"
                     /db_xref="CDD:410433"
     Region          2021..2206
                     /region_name="RhoGAP_myosin_IX"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain present in class IX myosins. Class
                     IX myosins contain a characteristic head domain, a neck
                     domain, a tail domain which contains a C6H2-zinc binding
                     motif and a RhoGAP domain. Class...; cd04377"
                     /db_xref="CDD:239842"
     Site            order(2058,2095,2099,2168,2171..2172,2197)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239842"
     Site            2058
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239842"
     CDS             1..2526
                     /gene="MYO9A"
                     /gene_synonym="CMS24"
                     /coded_by="XM_047432584.1:140..7720"
                     /db_xref="GeneID:4649"
                     /db_xref="HGNC:HGNC:7608"
                     /db_xref="MIM:604875"
ORIGIN      
        1 mnindggrrr fednehtlri ypgaisegti ycpiparkns taaeviesli nklhldktkc
       61 yvlaevkefg geewilnptd cpvqrmmlwp rmalenrlsg edyrfllrek nldgsihygs
      121 lqswlrvtee rrrmmergfl pqpqqkdfdd lcslpdlnek tllenlrnrf khekiytyvg
      181 silivinpfk flpiynpkyv kmydnhqlgk lephiyavad vayhamlqrk knqcivisge
      241 sgsgktqstn flihhltals qkgfasgveq iilgagpvle afgnaktahn nnssrfgkfi
      301 qvnyqetgtv lgayvekyll eksrlvyqeh nernyhvfyy llagaseder safhlkqpee
      361 yhylnqitkk plrqswddyc ydsepdcftv egedlrhdfe rlqlamemvg flpktrrqif
      421 sllsailhlg nicykkktyr ddsidicnpe vlpivselle vkeemlfeal vtrktvtvge
      481 klilpyklae avtvrnsmak slysalfdwi vfrinhalln skdlehntkt lsigvldifg
      541 fedyennsfe qfcinfaner lqhyfnqhif kleqeeyrte giswhnidyi dntccinlis
      601 kkptgllhll deesnfpqat nqtlldkfkh qhednsyief pavmepafii khyagkvkyg
      661 vkdfrekntd hmrpdivall rssknafisg migidpvavf rwailraffr amvafreagk
      721 rnihrktgit rknprtplsd lqgmnalnek nqhdtfdiaw ngrtgirqsr lssgtslldk
      781 dgifanstss kllerahgil trnknfkskp alpkhllevn slkhltrltl qdritksllh
      841 lhkkkkppsi saqfqaslsk lmetlgqaep yfvkcirsna eklplrfsdv lvlrqlrytg
      901 mletvrirqs gysskysfqd fvshfhvllp rniipskfni qdffrkinln pdnyqvgktm
      961 vflkeqerqh lqdllhqevl rriillqrwf rvllcrqhfl hlrqasviiq rfwrnylnqk
     1021 qvrdaavqkd afvmasaaal lqaswrahle rqrylelraa aiviqqkwrd yyrrrhmaai
     1081 ciqarwkayr eskryqeqrk kiillqstcr gfrarqrfka lkeqrlretk pevglvnikg
     1141 ygsleiqgsd psgwedcsfd nrikaieeck sviesnrisr essvdclkes pnkqqeraqs
     1201 qsgvdlqedv lvrerprsle dlhqkkvgra kresrrmrel eqaifslell kvrslggisp
     1261 sedrrwstel vpeglqsprg tpdsessqgs lellsyeesq ksklesvisd egdlqfpspk
     1321 issspkfdsr dnalsasnet ssaehlkdgt mkemvvcsse sitckpqlkd sfisnslptf
     1381 fyipqqdplk tnsqldtsiq rnkllenedt agealtldin retrryhcsg kdqivpslnt
     1441 essnpvlkkl eklntekeer qkqlqqqnek emmeqirqqt dilekerkaf ktiekprige
     1501 clvapssyqs kqrverpssl lslntsnkge lnvlgslslk daalaqkdss sahlppkdrp
     1561 vtvfferkgs pcqsstvkel sktdrmgtql nvacklsnnr iskrehfrpt qsyshnsddl
     1621 sregnarpif ftpkdnmsip lvskealnsk npqlhkedep awkpvklagp gqretsqrfs
     1681 svdeqaklhk tmsqgeitkl avrqkasdsd irpqrakmrf wakgkqgekk ttrvkpttqs
     1741 evsplfagtd vipahqfpde laayhptppl spelpgscrk efkenkepsp kakrkrsvki
     1801 snvaldsmhw qndsvqiias vsdlksmdef llkkvndldn edskkdtlvd vvfkkalkef
     1861 rqnifsfyss alamddgksi rykdlyalfe qilektmrle qrdslgespv rvwvntfkvf
     1921 ldeymnefkt sdctatkvpk terkkrrkke tdlveehngh ifkatqysip tyceycssli
     1981 wimdrasvck lckyachkkc clkttakcsk kydpelssrq fgvelsrlts edrtvplvve
     2041 klinyiemhg lytegiyrks gstnkikelr qgldtdaesv nlddynihvi asvfkqwlrd
     2101 lpnplmtfel yeeflramgl qerketirgv ysvidqlsrt hlntlerlif hlvrialqed
     2161 tnrmsanala ivfapcilrc pdttdplqsv qdisktttcv elivveqmnk ykarlkdiss
     2221 lefaenkakt rlslirrsmk pvliavrfmn itrnsvsgkg rirrgnypgp sspvvvrlps
     2281 vsdvseetlt seaametdit eqqqaamqqe ervlteqien lqkekeeltf emlvlepras
     2341 ddetleseas igtadssenl nmeseyaise kserslalss lktagkseps sklrkqlkkq
     2401 qdsldvvdss vsslclsnta sshgtrklfq iyskspfyra asgnealgme gplgqtkfle
     2461 dkpqfisrgt fnpekgkqkl knvknspqkt ketpegtvms grrktvdpdc tsnqqlalfg
     2521 nnefmv
//
LOCUS       XP_047288541            2507 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-IXa isoform X20 [Homo sapiens].
ACCESSION   XP_047288541
VERSION     XP_047288541.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432585.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2507
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2507
                     /product="unconventional myosin-IXa isoform X20"
                     /calculated_mol_wt=287606
     Region          15..110
                     /region_name="RA_Myosin-IXa"
                     /note="Ras-associating (RA) domain found in Myosin-IXa;
                     cd17216"
                     /db_xref="CDD:340736"
     Region          160..945
                     /region_name="MYSc_Myo9"
                     /note="class IX myosin, motor domain; cd01385"
                     /db_xref="CDD:276836"
     Site            order(187..195,239..246,285..295,518..523)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276836"
     Site            187..195
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276836"
     Site            239..246
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276836"
     Site            285..295
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276836"
     Site            461
                     /site_type="other"
                     /note="putative phosphorylation site [posttranslational
                     modification]"
                     /db_xref="CDD:276836"
     Site            518..523
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276836"
     Site            order(547..558,561..570)
                     /site_type="active"
                     /note="relay loop [active]"
                     /db_xref="CDD:276836"
     Site            881..890
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276836"
     Site            order(893..920,924..945)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276836"
     Region          1936..1993
                     /region_name="C1_Myosin-IXa"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in unconventional myosin-IXa and similar proteins;
                     cd20883"
                     /db_xref="CDD:410433"
     Region          2002..2187
                     /region_name="RhoGAP_myosin_IX"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain present in class IX myosins. Class
                     IX myosins contain a characteristic head domain, a neck
                     domain, a tail domain which contains a C6H2-zinc binding
                     motif and a RhoGAP domain. Class...; cd04377"
                     /db_xref="CDD:239842"
     Site            order(2039,2076,2080,2149,2152..2153,2178)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239842"
     Site            2039
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239842"
     CDS             1..2507
                     /gene="MYO9A"
                     /gene_synonym="CMS24"
                     /coded_by="XM_047432585.1:346..7869"
                     /db_xref="GeneID:4649"
                     /db_xref="HGNC:HGNC:7608"
                     /db_xref="MIM:604875"
ORIGIN      
        1 mnindggrrr fednehtlri ypgaisegti ycpiparkns taaeviesli nklhldktkc
       61 yvlaevkefg geewilnptd cpvqrmmlwp rmalenrlsg edyrfllrek nldgsihygs
      121 lqswlrvtee rrrmmergfl pqpqqkdfdd lcslpdlnek tllenlrnrf khekiytyvg
      181 silivinpfk flpiynpkyv kmydnhqlgk lephiyavad vayhamlqrk knqcivisge
      241 sgsgktqstn flihhltals qkgfasgveq iilgagpvle afgnaktahn nnssrfgkfi
      301 qvnyqetgtv lgayvekyll eksrlvyqeh nernyhvfyy llagaseder safhlkqpee
      361 yhylnqdcft vegedlrhdf erlqlamemv gflpktrrqi fsllsailhl gnicykkkty
      421 rddsidicnp evlpivsell evkeemlfea lvtrktvtvg eklilpykla eavtvrnsma
      481 kslysalfdw ivfrinhall nskdlehntk tlsigvldif gfedyennsf eqfcinfane
      541 rlqhyfnqhi fkleqeeyrt egiswhnidy idntccinli skkptgllhl ldeesnfpqa
      601 tnqtlldkfk hqhednsyie fpavmepafi ikhyagkvky gvkdfreknt dhmrpdival
      661 lrssknafis gmigidpvav frwailraff ramvafreag krnihrktgi trknprtpls
      721 dlqgmnalne knqhdtfdia wngrtgirqs rlssgtslld kdgifansts skllerahgi
      781 ltrnknfksk palpkhllev nslkhltrlt lqdritksll hlhkkkkpps isaqfqasls
      841 klmetlgqae pyfvkcirsn aeklplrfsd vlvlrqlryt gmletvrirq sgysskysfq
      901 dfvshfhvll prniipskfn iqdffrkinl npdnyqvgkt mvflkeqerq hlqdllhqev
      961 lrriillqrw frvllcrqhf lhlrqasvii qrfwrnylnq kqvrdaavqk dafvmasaaa
     1021 llqaswrahl erqrylelra aaiviqqkwr dyyrrrhmaa iciqarwkay reskryqeqr
     1081 kkiillqstc rgfrarqrfk alkeqrlret kpevglvnik gygsleiqgs dpsgwedcsf
     1141 dnrikaieec ksviesnris ressvdclke spnkqqeraq sqsgvdlqed vlvrerprsl
     1201 edlhqkkvgr akresrrmre leqaifslel lkvrslggis psedrrwste lvpeglqspr
     1261 gtpdsessqg slellsyees qksklesvis degdlqfpsp kissspkfds rdnalsasne
     1321 tssaehlkdg tmkemvvcss esitckpqlk dsfisnslpt ffyipqqdpl ktnsqldtsi
     1381 qrnkllened tagealtldi nretrryhcs gkdqivpsln tessnpvlkk leklntekee
     1441 rqkqlqqqne kemmeqirqq tdilekerka fktiekprig eclvapssyq skqrverpss
     1501 llslntsnkg elnvlgslsl kdaalaqkds ssahlppkdr pvtvfferkg spcqsstvke
     1561 lsktdrmgtq lnvacklsnn riskrehfrp tqsyshnsdd lsregnarpi fftpkdnmsi
     1621 plvskealns knpqlhkede pawkpvklag pgqretsqrf ssvdeqaklh ktmsqgeitk
     1681 lavrqkasds dirpqrakmr fwakgkqgek kttrvkpttq sevsplfagt dvipahqfpd
     1741 elaayhptpp lspelpgscr kefkenkeps pkakrkrsvk isnvaldsmh wqndsvqiia
     1801 svsdlksmde fllkkvndld nedskkdtlv dvvfkkalke frqnifsfys salamddgks
     1861 irykdlyalf eqilektmrl eqrdslgesp vrvwvntfkv fldeymnefk tsdctatkvp
     1921 kterkkrrkk etdlveehng hifkatqysi ptyceycssl iwimdrasvc klckyachkk
     1981 cclkttakcs kkydpelssr qfgvelsrlt sedrtvplvv eklinyiemh glytegiyrk
     2041 sgstnkikel rqgldtdaes vnlddynihv iasvfkqwlr dlpnplmtfe lyeeflramg
     2101 lqerketirg vysvidqlsr thlntlerli fhlvrialqe dtnrmsanal aivfapcilr
     2161 cpdttdplqs vqdisktttc velivveqmn kykarlkdis slefaenkak trlslirrsm
     2221 kpvliavrfm nitrnsvsgk grirrgnypg psspvvvrlp svsdvseetl tseaametdi
     2281 teqqqaamqq eervlteqie nlqkekeelt femlvlepra sddetlesea sigtadssen
     2341 lnmeseyais ekserslals slktagksep ssklrkqlkk qqdsldvvds svsslclsnt
     2401 asshgtrklf qiyskspfyr aasgnealgm egplgqtkfl edkpqfisrg tfnpekgkqk
     2461 lknvknspqk tketpegtvm sgrrktvdpd ctsnqqlalf gnnefmv
//
LOCUS       XP_011519926             875 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase NEDD4 isoform X1 [Homo sapiens].
ACCESSION   XP_011519926
VERSION     XP_011519926.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521624.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..875
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..875
                     /product="E3 ubiquitin-protein ligase NEDD4 isoform X1"
                     /calculated_mol_wt=101776
     Region          15..126
                     /region_name="C2_NEDD4_NEDD4L"
                     /note="C2 domain present in the Human neural precursor
                     cell-expressed, developmentally down-regulated 4 (NEDD4)
                     and NEDD4-like (NEDD4L/NEDD42); cd04033"
                     /db_xref="CDD:175999"
     Site            order(16,68,70,75)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:175999"
     Region          167..199
                     /region_name="WW"
                     /note="Domain with 2 conserved Trp (W) residues;
                     smart00456"
                     /db_xref="CDD:197736"
     Site            order(183,194)
                     /site_type="active"
                     /note="binding pocket [active]"
                     /db_xref="CDD:238122"
     Region          325..354
                     /region_name="WW"
                     /note="WW domain; pfam00397"
                     /db_xref="CDD:459800"
     Region          398..427
                     /region_name="WW"
                     /note="WW domain; pfam00397"
                     /db_xref="CDD:459800"
     Region          449..481
                     /region_name="WW"
                     /note="Domain with 2 conserved Trp (W) residues;
                     smart00456"
                     /db_xref="CDD:197736"
     Site            order(465,476)
                     /site_type="active"
                     /note="binding pocket [active]"
                     /db_xref="CDD:238122"
     Site            order(524,555,566,628,801,836..837,840..844,864,871)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Region          542..871
                     /region_name="HECTc"
                     /note="Domain Homologous to E6-AP Carboxyl Terminus with;
                     smart00119"
                     /db_xref="CDD:214523"
     Site            order(656,659..660,662..663,666,671,673,677..678,679,685,
                     690,707,711)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..875
                     /gene="NEDD4"
                     /gene_synonym="NEDD4-1; RPF1"
                     /coded_by="XM_011521624.4:64..2691"
                     /db_xref="GeneID:4734"
                     /db_xref="HGNC:HGNC:7727"
                     /db_xref="MIM:602278"
ORIGIN      
        1 mlrvfwclrv wpiksdpyvr vtlydpmngv ltsvqtktik kslnpkwnee ilfrvhpqqh
       61 rllfevfden rltrddflgq vdvplyplpt enprlerpyt fkdfvlhprs hksrvkgylr
      121 lkmtylpkts gseddnaeqa eelepgwvvl dqpdaachlq qqqepsplpp gweerqdilg
      181 rtyyvnhesr rtqwkrptpq dnltdaengn iqlqaqraft trrqiseete svdnressen
      241 weiiredeat mysnqafpsp ppssnldvpt hlaeelnarl tifgnsavsq passsnhssr
      301 rgslqaytfe eqptlpvllp tssglppgwe ekqdergrsy yvdhnsrttt wtkptvqatv
      361 etsqltssqs sagpqsqast sdsgqqvtqp seieqgflpk gwevrhapng rpffidhntk
      421 tttwedprlk ipahlrgkts ldtsndlgpl ppgweertht dgrifyinhn ikrtqwedpr
      481 lenvaitgpa vpysrdykrk yeffrrklkk qndipnkfem klrratvled syrrimgvkr
      541 adflkarlwi efdgekgldy ggvarewffl iskemfnpyy glfeysatdn ytlqinpnsg
      601 lcnedhlsyf kfigrvagma vyhgklldgf firpfykmml hkpitlhdme svdseyynsl
      661 rwilendpte ldlrfiidee lfgqthqhel knggseivvt nknkkeyiyl viqwrfvnri
      721 qkqmaafkeg ffelipqdli kifdenelel lmcglgdvdv ndwrehtkyk ngysanhqvi
      781 qwfwkavlmm dsekrirllq fvtgtsrvpm ngfaelygsn gpqsftveqw gtpeklprah
      841 tcfnrldlpp yesfeelwdk lqmaientqg fdgvd
//
LOCUS       XP_011519927             849 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase NEDD4 isoform X2 [Homo sapiens].
ACCESSION   XP_011519927
VERSION     XP_011519927.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521625.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..849
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..849
                     /product="E3 ubiquitin-protein ligase NEDD4 isoform X2"
                     /calculated_mol_wt=98540
     Region          <1..100
                     /region_name="C2_NEDD4_NEDD4L"
                     /note="C2 domain present in the Human neural precursor
                     cell-expressed, developmentally down-regulated 4 (NEDD4)
                     and NEDD4-like (NEDD4L/NEDD42); cd04033"
                     /db_xref="CDD:175999"
     Region          141..173
                     /region_name="WW"
                     /note="Domain with 2 conserved Trp (W) residues;
                     smart00456"
                     /db_xref="CDD:197736"
     Site            order(157,168)
                     /site_type="active"
                     /note="binding pocket [active]"
                     /db_xref="CDD:238122"
     Region          299..328
                     /region_name="WW"
                     /note="WW domain; pfam00397"
                     /db_xref="CDD:459800"
     Region          372..401
                     /region_name="WW"
                     /note="WW domain; pfam00397"
                     /db_xref="CDD:459800"
     Region          423..455
                     /region_name="WW"
                     /note="Domain with 2 conserved Trp (W) residues;
                     smart00456"
                     /db_xref="CDD:197736"
     Site            order(439,450)
                     /site_type="active"
                     /note="binding pocket [active]"
                     /db_xref="CDD:238122"
     Site            order(498,529,540,602,775,810..811,814..818,838,845)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Region          516..845
                     /region_name="HECTc"
                     /note="Domain Homologous to E6-AP Carboxyl Terminus with;
                     smart00119"
                     /db_xref="CDD:214523"
     Site            order(630,633..634,636..637,640,645,647,651..652,653,659,
                     664,681,685)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..849
                     /gene="NEDD4"
                     /gene_synonym="NEDD4-1; RPF1"
                     /coded_by="XM_011521625.4:291..2840"
                     /db_xref="GeneID:4734"
                     /db_xref="HGNC:HGNC:7727"
                     /db_xref="MIM:602278"
ORIGIN      
        1 mngvltsvqt ktikkslnpk wneeilfrvh pqqhrllfev fdenrltrdd flgqvdvply
       61 plptenprle rpytfkdfvl hprshksrvk gylrlkmtyl pktsgseddn aeqaeelepg
      121 wvvldqpdaa chlqqqqeps plppgweerq dilgrtyyvn hesrrtqwkr ptpqdnltda
      181 engniqlqaq rafttrrqis eetesvdnre ssenweiire deatmysnqa fpspppssnl
      241 dvpthlaeel narltifgns avsqpasssn hssrrgslqa ytfeeqptlp vllptssglp
      301 pgweekqder grsyyvdhns rtttwtkptv qatvetsqlt ssqssagpqs qastsdsgqq
      361 vtqpseieqg flpkgwevrh apngrpffid hntktttwed prlkipahlr gktsldtsnd
      421 lgplppgwee rthtdgrify inhnikrtqw edprlenvai tgpavpysrd ykrkyeffrr
      481 klkkqndipn kfemklrrat vledsyrrim gvkradflka rlwiefdgek gldyggvare
      541 wffliskemf npyyglfeys atdnytlqin pnsglcnedh lsyfkfigrv agmavyhgkl
      601 ldgffirpfy kmmlhkpitl hdmesvdsey ynslrwilen dpteldlrfi ideelfgqth
      661 qhelknggse ivvtnknkke yiylviqwrf vnriqkqmaa fkegffelip qdlikifden
      721 elellmcglg dvdvndwreh tkykngysan hqviqwfwka vlmmdsekri rllqfvtgts
      781 rvpmngfael ygsngpqsft veqwgtpekl prahtcfnrl dlppyesfee lwdklqmaie
      841 ntqgfdgvd
//
LOCUS       XP_011519928             849 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase NEDD4 isoform X2 [Homo sapiens].
ACCESSION   XP_011519928
VERSION     XP_011519928.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521626.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..849
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..849
                     /product="E3 ubiquitin-protein ligase NEDD4 isoform X2"
                     /calculated_mol_wt=98540
     Region          <1..100
                     /region_name="C2_NEDD4_NEDD4L"
                     /note="C2 domain present in the Human neural precursor
                     cell-expressed, developmentally down-regulated 4 (NEDD4)
                     and NEDD4-like (NEDD4L/NEDD42); cd04033"
                     /db_xref="CDD:175999"
     Region          141..173
                     /region_name="WW"
                     /note="Domain with 2 conserved Trp (W) residues;
                     smart00456"
                     /db_xref="CDD:197736"
     Site            order(157,168)
                     /site_type="active"
                     /note="binding pocket [active]"
                     /db_xref="CDD:238122"
     Region          299..328
                     /region_name="WW"
                     /note="WW domain; pfam00397"
                     /db_xref="CDD:459800"
     Region          372..401
                     /region_name="WW"
                     /note="WW domain; pfam00397"
                     /db_xref="CDD:459800"
     Region          423..455
                     /region_name="WW"
                     /note="Domain with 2 conserved Trp (W) residues;
                     smart00456"
                     /db_xref="CDD:197736"
     Site            order(439,450)
                     /site_type="active"
                     /note="binding pocket [active]"
                     /db_xref="CDD:238122"
     Site            order(498,529,540,602,775,810..811,814..818,838,845)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Region          516..845
                     /region_name="HECTc"
                     /note="Domain Homologous to E6-AP Carboxyl Terminus with;
                     smart00119"
                     /db_xref="CDD:214523"
     Site            order(630,633..634,636..637,640,645,647,651..652,653,659,
                     664,681,685)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..849
                     /gene="NEDD4"
                     /gene_synonym="NEDD4-1; RPF1"
                     /coded_by="XM_011521626.2:70..2619"
                     /db_xref="GeneID:4734"
                     /db_xref="HGNC:HGNC:7727"
                     /db_xref="MIM:602278"
ORIGIN      
        1 mngvltsvqt ktikkslnpk wneeilfrvh pqqhrllfev fdenrltrdd flgqvdvply
       61 plptenprle rpytfkdfvl hprshksrvk gylrlkmtyl pktsgseddn aeqaeelepg
      121 wvvldqpdaa chlqqqqeps plppgweerq dilgrtyyvn hesrrtqwkr ptpqdnltda
      181 engniqlqaq rafttrrqis eetesvdnre ssenweiire deatmysnqa fpspppssnl
      241 dvpthlaeel narltifgns avsqpasssn hssrrgslqa ytfeeqptlp vllptssglp
      301 pgweekqder grsyyvdhns rtttwtkptv qatvetsqlt ssqssagpqs qastsdsgqq
      361 vtqpseieqg flpkgwevrh apngrpffid hntktttwed prlkipahlr gktsldtsnd
      421 lgplppgwee rthtdgrify inhnikrtqw edprlenvai tgpavpysrd ykrkyeffrr
      481 klkkqndipn kfemklrrat vledsyrrim gvkradflka rlwiefdgek gldyggvare
      541 wffliskemf npyyglfeys atdnytlqin pnsglcnedh lsyfkfigrv agmavyhgkl
      601 ldgffirpfy kmmlhkpitl hdmesvdsey ynslrwilen dpteldlrfi ideelfgqth
      661 qhelknggse ivvtnknkke yiylviqwrf vnriqkqmaa fkegffelip qdlikifden
      721 elellmcglg dvdvndwreh tkykngysan hqviqwfwka vlmmdsekri rllqfvtgts
      781 rvpmngfael ygsngpqsft veqwgtpekl prahtcfnrl dlppyesfee lwdklqmaie
      841 ntqgfdgvd
//
LOCUS       XP_011519930            1481 aa            linear   PRI 05-AUG-2025
DEFINITION  neogenin isoform X1 [Homo sapiens].
ACCESSION   XP_011519930
VERSION     XP_011519930.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521628.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1481
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1481
                     /product="neogenin isoform X1"
                     /calculated_mol_wt=161918
     Region          52..148
                     /region_name="IgI_1_Neogenin_like"
                     /note="First immunoglobulin (Ig)-like domain in neogenin,
                     and similar domains; member of the I-set of Ig superfamily
                     (IgSF) domains; cd05722"
                     /db_xref="CDD:409387"
     Region          52..55
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409387"
     Region          58..64
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409387"
     Region          68..78
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409387"
     Region          82..88
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409387"
     Region          90..93
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409387"
     Region          100..105
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409387"
     Region          107..113
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409387"
     Region          125..132
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409387"
     Region          137..148
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409387"
     Region          158..239
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          169..173
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          182..186
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          204..208
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          218..223
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          250..337
                     /region_name="I-set"
                     /note="Immunoglobulin I-set domain; pfam07679"
                     /db_xref="CDD:400151"
     Region          266..270
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          279..283
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          303..307
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          317..322
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          330..333
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          344..427
                     /region_name="IgI_4_Neogenin_like"
                     /note="Fourth immunoglobulin (Ig)-like domain in neogenin,
                     and similar domains; member of the I-set of Ig superfamily
                     (IgSF) domains; cd05723"
                     /db_xref="CDD:409388"
     Region          344..347
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409388"
     Region          349..353
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409388"
     Region          356..365
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409388"
     Region          370..376
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409388"
     Region          378..381
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409388"
     Region          386..390
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409388"
     Region          394..398
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409388"
     Region          406..414
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409388"
     Region          417..427
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409388"
     Region          459..552
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(459,525,540)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          <522..944
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     Site            order(541..542,544..545)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          976..1071
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(1060..1061,1063..1064)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1178..1481
                     /region_name="Neogenin_C"
                     /note="Neogenin C-terminus; pfam06583"
                     /db_xref="CDD:461954"
     CDS             1..1481
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /coded_by="XM_011521628.3:284..4729"
                     /db_xref="GeneID:4756"
                     /db_xref="HGNC:HGNC:7754"
                     /db_xref="MIM:601907"
ORIGIN      
        1 maaergarrl lstpsfwlyc llllgrrapg aaaarsgsap qspgasirtf tpfyflvepv
       61 dtlsvrgssv ilncsaysep spkiewkkdg tflnlvsddr rqllpdgslf isnvvhskhn
      121 kpdegyyqcv atveslgtii srtaklivag lprftsqpep ssvyagnnai lncevnadlv
      181 pfvrweqnrq plllddrvik lpsgmlvisn ategdgglyr cvvesggppk ysdevelkvl
      241 pdpevisdlv flkqpsplvr vigqdvvlpc vasglptpti kwmkneeald tesserlvll
      301 aggsleisdv teddagtyfc iadngnetie aqaeltvqaq peflkqptni yahesmdivf
      361 ecevtgkptp tvkwvkngdm vipsdyfkiv kehnlqvlgl vksdegfyqc iaendvgnaq
      421 agaqliileh dvaiptlppt sltsattdhl apattgplps aprdvvaslv strfikltwr
      481 tpasdphgdn ltysvfytke giarervent shpgemqvti qnlmpatvyi frvmaqnkhg
      541 sgessaplrv etqpevqlpg papnlrayaa sptsitvtwe tpvsgngeiq nyklyymekg
      601 tdkeqdvdvs shsytinglk kyteysfrvv aynkhgpgvs tpdvavrtls dvpsaapqnl
      661 slevrnsksi mihwqppapa tqngqitgyk iryrkasrks dvtetlvsgt qlsqliegld
      721 rgteynfrva altingtgpa tdwlsaetfe sdldetrvpe vpsslhvrpl vtsivvswtp
      781 penqnivvrg yaigygigsp haqtikvdyk qryytienld psshyvitlk afnnvgegip
      841 lyesavtrph tdtsevdlfv inapytpvpd ptpmmppvgv qasilshdti ritwadnslp
      901 khqkitdsry ytvrwktnip antkyknana ttlsylvtgl kpntlyefsv mvtkgrrsst
      961 wsmtahgttf elvptsppkd vtvvskegkp ktiivnwqpp seangkitgy iiyystdvna
     1021 eihdwviepv vgnrlthqiq eltldtpyyf kiqarnskgm gpmseavqfr tpkadssdkm
     1081 pndqasgsgg kgsrlpdlgs dykppmsgsn sphgsptspl dsnmllviiv svgvitivvv
     1141 viiavfctrr ttshqkkkra acksvngshk ykgnskdvkp pdlwihherl elkpidkspd
     1201 pnpimtdtpi prnsqditpv dnsmdsnihq rrnsyrghes edsmstlagr rgmrpkmmmp
     1261 fdsqppqpvi sahpihsldn phhhfhsssl asparshlyh pgspwpigts mslsdranst
     1321 esvrntpstd tmpasssqtc ctdhqdpega tsssylassq eedsgqslpt ahvrpshplk
     1381 sfavpaippp gpptydpalp stpllsqqal nhhihsvkta sigtlgrsrp pmpvvvpsap
     1441 evqettrmle dsessyepde ltkemahleg lmkdlnaitt a
//
LOCUS       XP_011519931            1470 aa            linear   PRI 05-AUG-2025
DEFINITION  neogenin isoform X2 [Homo sapiens].
ACCESSION   XP_011519931
VERSION     XP_011519931.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521629.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1470
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1470
                     /product="neogenin isoform X2"
                     /calculated_mol_wt=160729
     Region          52..148
                     /region_name="IgI_1_Neogenin_like"
                     /note="First immunoglobulin (Ig)-like domain in neogenin,
                     and similar domains; member of the I-set of Ig superfamily
                     (IgSF) domains; cd05722"
                     /db_xref="CDD:409387"
     Region          52..55
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409387"
     Region          58..64
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409387"
     Region          68..78
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409387"
     Region          82..88
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409387"
     Region          90..93
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409387"
     Region          100..105
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409387"
     Region          107..113
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409387"
     Region          125..132
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409387"
     Region          137..148
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409387"
     Region          158..239
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          169..173
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          182..186
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          204..208
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          218..223
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          250..337
                     /region_name="I-set"
                     /note="Immunoglobulin I-set domain; pfam07679"
                     /db_xref="CDD:400151"
     Region          266..270
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          279..283
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          303..307
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          317..322
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          330..333
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          344..427
                     /region_name="IgI_4_Neogenin_like"
                     /note="Fourth immunoglobulin (Ig)-like domain in neogenin,
                     and similar domains; member of the I-set of Ig superfamily
                     (IgSF) domains; cd05723"
                     /db_xref="CDD:409388"
     Region          344..347
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409388"
     Region          349..353
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409388"
     Region          356..365
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409388"
     Region          370..376
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409388"
     Region          378..381
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409388"
     Region          386..390
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409388"
     Region          394..398
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409388"
     Region          406..414
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409388"
     Region          417..427
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409388"
     Region          459..552
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(459,525,540)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          <522..944
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     Site            order(541..542,544..545)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          976..1071
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(1060..1061,1063..1064)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1167..1470
                     /region_name="Neogenin_C"
                     /note="Neogenin C-terminus; pfam06583"
                     /db_xref="CDD:461954"
     CDS             1..1470
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /coded_by="XM_011521629.3:284..4696"
                     /db_xref="GeneID:4756"
                     /db_xref="HGNC:HGNC:7754"
                     /db_xref="MIM:601907"
ORIGIN      
        1 maaergarrl lstpsfwlyc llllgrrapg aaaarsgsap qspgasirtf tpfyflvepv
       61 dtlsvrgssv ilncsaysep spkiewkkdg tflnlvsddr rqllpdgslf isnvvhskhn
      121 kpdegyyqcv atveslgtii srtaklivag lprftsqpep ssvyagnnai lncevnadlv
      181 pfvrweqnrq plllddrvik lpsgmlvisn ategdgglyr cvvesggppk ysdevelkvl
      241 pdpevisdlv flkqpsplvr vigqdvvlpc vasglptpti kwmkneeald tesserlvll
      301 aggsleisdv teddagtyfc iadngnetie aqaeltvqaq peflkqptni yahesmdivf
      361 ecevtgkptp tvkwvkngdm vipsdyfkiv kehnlqvlgl vksdegfyqc iaendvgnaq
      421 agaqliileh dvaiptlppt sltsattdhl apattgplps aprdvvaslv strfikltwr
      481 tpasdphgdn ltysvfytke giarervent shpgemqvti qnlmpatvyi frvmaqnkhg
      541 sgessaplrv etqpevqlpg papnlrayaa sptsitvtwe tpvsgngeiq nyklyymekg
      601 tdkeqdvdvs shsytinglk kyteysfrvv aynkhgpgvs tpdvavrtls dvpsaapqnl
      661 slevrnsksi mihwqppapa tqngqitgyk iryrkasrks dvtetlvsgt qlsqliegld
      721 rgteynfrva altingtgpa tdwlsaetfe sdldetrvpe vpsslhvrpl vtsivvswtp
      781 penqnivvrg yaigygigsp haqtikvdyk qryytienld psshyvitlk afnnvgegip
      841 lyesavtrph tdtsevdlfv inapytpvpd ptpmmppvgv qasilshdti ritwadnslp
      901 khqkitdsry ytvrwktnip antkyknana ttlsylvtgl kpntlyefsv mvtkgrrsst
      961 wsmtahgttf elvptsppkd vtvvskegkp ktiivnwqpp seangkitgy iiyystdvna
     1021 eihdwviepv vgnrlthqiq eltldtpyyf kiqarnskgm gpmseavqfr tpkasgsggk
     1081 gsrlpdlgsd ykppmsgsns phgsptspld snmllviivs vgvitivvvv iiavfctrrt
     1141 tshqkkkraa cksvngshky kgnskdvkpp dlwihherle lkpidkspdp npimtdtpip
     1201 rnsqditpvd nsmdsnihqr rnsyrghese dsmstlagrr gmrpkmmmpf dsqppqpvis
     1261 ahpihsldnp hhhfhsssla sparshlyhp gspwpigtsm slsdranste svrntpstdt
     1321 mpasssqtcc tdhqdpegat sssylassqe edsgqslpta hvrpshplks favpaipppg
     1381 pptydpalps tpllsqqaln hhihsvktas igtlgrsrpp mpvvvpsape vqettrmled
     1441 sessyepdel tkemahlegl mkdlnaitta
//
LOCUS       XP_011519932            1465 aa            linear   PRI 05-AUG-2025
DEFINITION  neogenin isoform X3 [Homo sapiens].
ACCESSION   XP_011519932
VERSION     XP_011519932.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521630.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1465
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1465
                     /product="neogenin isoform X3"
                     /calculated_mol_wt=160155
     Region          52..148
                     /region_name="IgI_1_Neogenin_like"
                     /note="First immunoglobulin (Ig)-like domain in neogenin,
                     and similar domains; member of the I-set of Ig superfamily
                     (IgSF) domains; cd05722"
                     /db_xref="CDD:409387"
     Region          52..55
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409387"
     Region          58..64
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409387"
     Region          68..78
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409387"
     Region          82..88
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409387"
     Region          90..93
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409387"
     Region          100..105
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409387"
     Region          107..113
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409387"
     Region          125..132
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409387"
     Region          137..148
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409387"
     Region          158..239
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          169..173
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          182..186
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          204..208
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          218..223
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          250..337
                     /region_name="I-set"
                     /note="Immunoglobulin I-set domain; pfam07679"
                     /db_xref="CDD:400151"
     Region          266..270
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          279..283
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          303..307
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          317..322
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          330..333
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          344..427
                     /region_name="IgI_4_Neogenin_like"
                     /note="Fourth immunoglobulin (Ig)-like domain in neogenin,
                     and similar domains; member of the I-set of Ig superfamily
                     (IgSF) domains; cd05723"
                     /db_xref="CDD:409388"
     Region          344..347
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409388"
     Region          349..353
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409388"
     Region          356..365
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409388"
     Region          370..376
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409388"
     Region          378..381
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409388"
     Region          386..390
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409388"
     Region          394..398
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409388"
     Region          406..414
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409388"
     Region          417..427
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409388"
     Region          459..552
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(459,525,540)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          <522..928
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     Site            order(541..542,544..545)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          960..1055
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(1044..1045,1047..1048)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1162..1465
                     /region_name="Neogenin_C"
                     /note="Neogenin C-terminus; pfam06583"
                     /db_xref="CDD:461954"
     CDS             1..1465
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /coded_by="XM_011521630.3:284..4681"
                     /db_xref="GeneID:4756"
                     /db_xref="HGNC:HGNC:7754"
                     /db_xref="MIM:601907"
ORIGIN      
        1 maaergarrl lstpsfwlyc llllgrrapg aaaarsgsap qspgasirtf tpfyflvepv
       61 dtlsvrgssv ilncsaysep spkiewkkdg tflnlvsddr rqllpdgslf isnvvhskhn
      121 kpdegyyqcv atveslgtii srtaklivag lprftsqpep ssvyagnnai lncevnadlv
      181 pfvrweqnrq plllddrvik lpsgmlvisn ategdgglyr cvvesggppk ysdevelkvl
      241 pdpevisdlv flkqpsplvr vigqdvvlpc vasglptpti kwmkneeald tesserlvll
      301 aggsleisdv teddagtyfc iadngnetie aqaeltvqaq peflkqptni yahesmdivf
      361 ecevtgkptp tvkwvkngdm vipsdyfkiv kehnlqvlgl vksdegfyqc iaendvgnaq
      421 agaqliileh dvaiptlppt sltsattdhl apattgplps aprdvvaslv strfikltwr
      481 tpasdphgdn ltysvfytke giarervent shpgemqvti qnlmpatvyi frvmaqnkhg
      541 sgessaplrv etqpevqlpg papnlrayaa sptsitvtwe tpvsgngeiq nyklyymekg
      601 tdkeqdvdvs shsytinglk kyteysfrvv aynkhgpgvs tpdvavrtls dvpsaapqnl
      661 slevrnsksi mihwqppapa tqngqitgyk iryrkasrks dvtetlvsgt qlsqliegld
      721 rgteynfrva altingtgpa tdwlsaetfe sdldetrvpe vpsslhvrpl vtsivvswtp
      781 penqnivvrg yaigygigsp haqtikvdyk qryytienld psshyvitlk afnnvgegip
      841 lyesavtrph tvpdptpmmp pvgvqasils hdtiritwad nslpkhqkit dsryytvrwk
      901 tnipantkyk nanattlsyl vtglkpntly efsvmvtkgr rsstwsmtah gttfelvpts
      961 ppkdvtvvsk egkpktiivn wqppseangk itgyiiyyst dvnaeihdwv iepvvgnrlt
     1021 hqiqeltldt pyyfkiqarn skgmgpmsea vqfrtpkads sdkmpndqas gsggkgsrlp
     1081 dlgsdykppm sgsnsphgsp tspldsnmll viivsvgvit ivvvviiavf ctrrttshqk
     1141 kkraacksvn gshkykgnsk dvkppdlwih herlelkpid kspdpnpimt dtpiprnsqd
     1201 itpvdnsmds nihqrrnsyr ghesedsmst lagrrgmrpk mmmpfdsqpp qpvisahpih
     1261 sldnphhhfh ssslaspars hlyhpgspwp igtsmslsdr anstesvrnt pstdtmpass
     1321 sqtcctdhqd pegatsssyl assqeedsgq slptahvrps hplksfavpa ipppgpptyd
     1381 palpstplls qqalnhhihs vktasigtlg rsrppmpvvv psapevqett rmledsessy
     1441 epdeltkema hleglmkdln aitta
//
LOCUS       XP_047288542            1461 aa            linear   PRI 05-AUG-2025
DEFINITION  neogenin isoform X4 [Homo sapiens].
ACCESSION   XP_047288542
VERSION     XP_047288542.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432586.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1461
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1461
                     /product="neogenin isoform X4"
                     /calculated_mol_wt=159886
     Region          52..148
                     /region_name="IgI_1_Neogenin_like"
                     /note="First immunoglobulin (Ig)-like domain in neogenin,
                     and similar domains; member of the I-set of Ig superfamily
                     (IgSF) domains; cd05722"
                     /db_xref="CDD:409387"
     Region          52..55
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409387"
     Region          58..64
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409387"
     Region          68..78
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409387"
     Region          82..88
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409387"
     Region          90..93
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409387"
     Region          100..105
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409387"
     Region          107..113
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409387"
     Region          125..132
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409387"
     Region          137..148
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409387"
     Region          158..239
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          169..173
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          182..186
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          204..208
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          218..223
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          250..337
                     /region_name="I-set"
                     /note="Immunoglobulin I-set domain; pfam07679"
                     /db_xref="CDD:400151"
     Region          266..270
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          279..283
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          303..307
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          317..322
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          330..333
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          344..427
                     /region_name="IgI_4_Neogenin_like"
                     /note="Fourth immunoglobulin (Ig)-like domain in neogenin,
                     and similar domains; member of the I-set of Ig superfamily
                     (IgSF) domains; cd05723"
                     /db_xref="CDD:409388"
     Region          344..347
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409388"
     Region          349..353
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409388"
     Region          356..365
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409388"
     Region          370..376
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409388"
     Region          378..381
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409388"
     Region          386..390
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409388"
     Region          394..398
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409388"
     Region          406..414
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409388"
     Region          417..427
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409388"
     Region          439..532
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(439,505,520)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          <502..924
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     Site            order(521..522,524..525)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          956..1051
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(1040..1041,1043..1044)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1158..1461
                     /region_name="Neogenin_C"
                     /note="Neogenin C-terminus; pfam06583"
                     /db_xref="CDD:461954"
     CDS             1..1461
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /coded_by="XM_047432586.1:284..4669"
                     /db_xref="GeneID:4756"
                     /db_xref="HGNC:HGNC:7754"
                     /db_xref="MIM:601907"
ORIGIN      
        1 maaergarrl lstpsfwlyc llllgrrapg aaaarsgsap qspgasirtf tpfyflvepv
       61 dtlsvrgssv ilncsaysep spkiewkkdg tflnlvsddr rqllpdgslf isnvvhskhn
      121 kpdegyyqcv atveslgtii srtaklivag lprftsqpep ssvyagnnai lncevnadlv
      181 pfvrweqnrq plllddrvik lpsgmlvisn ategdgglyr cvvesggppk ysdevelkvl
      241 pdpevisdlv flkqpsplvr vigqdvvlpc vasglptpti kwmkneeald tesserlvll
      301 aggsleisdv teddagtyfc iadngnetie aqaeltvqaq peflkqptni yahesmdivf
      361 ecevtgkptp tvkwvkngdm vipsdyfkiv kehnlqvlgl vksdegfyqc iaendvgnaq
      421 agaqliileh apattgplps aprdvvaslv strfikltwr tpasdphgdn ltysvfytke
      481 giarervent shpgemqvti qnlmpatvyi frvmaqnkhg sgessaplrv etqpevqlpg
      541 papnlrayaa sptsitvtwe tpvsgngeiq nyklyymekg tdkeqdvdvs shsytinglk
      601 kyteysfrvv aynkhgpgvs tpdvavrtls dvpsaapqnl slevrnsksi mihwqppapa
      661 tqngqitgyk iryrkasrks dvtetlvsgt qlsqliegld rgteynfrva altingtgpa
      721 tdwlsaetfe sdldetrvpe vpsslhvrpl vtsivvswtp penqnivvrg yaigygigsp
      781 haqtikvdyk qryytienld psshyvitlk afnnvgegip lyesavtrph tdtsevdlfv
      841 inapytpvpd ptpmmppvgv qasilshdti ritwadnslp khqkitdsry ytvrwktnip
      901 antkyknana ttlsylvtgl kpntlyefsv mvtkgrrsst wsmtahgttf elvptsppkd
      961 vtvvskegkp ktiivnwqpp seangkitgy iiyystdvna eihdwviepv vgnrlthqiq
     1021 eltldtpyyf kiqarnskgm gpmseavqfr tpkadssdkm pndqasgsgg kgsrlpdlgs
     1081 dykppmsgsn sphgsptspl dsnmllviiv svgvitivvv viiavfctrr ttshqkkkra
     1141 acksvngshk ykgnskdvkp pdlwihherl elkpidkspd pnpimtdtpi prnsqditpv
     1201 dnsmdsnihq rrnsyrghes edsmstlagr rgmrpkmmmp fdsqppqpvi sahpihsldn
     1261 phhhfhsssl asparshlyh pgspwpigts mslsdranst esvrntpstd tmpasssqtc
     1321 ctdhqdpega tsssylassq eedsgqslpt ahvrpshplk sfavpaippp gpptydpalp
     1381 stpllsqqal nhhihsvkta sigtlgrsrp pmpvvvpsap evqettrmle dsessyepde
     1441 ltkemahleg lmkdlnaitt a
//
LOCUS       XP_047288543            1454 aa            linear   PRI 05-AUG-2025
DEFINITION  neogenin isoform X5 [Homo sapiens].
ACCESSION   XP_047288543
VERSION     XP_047288543.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432587.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1454
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1454
                     /product="neogenin isoform X5"
                     /calculated_mol_wt=158966
     Region          52..148
                     /region_name="IgI_1_Neogenin_like"
                     /note="First immunoglobulin (Ig)-like domain in neogenin,
                     and similar domains; member of the I-set of Ig superfamily
                     (IgSF) domains; cd05722"
                     /db_xref="CDD:409387"
     Region          52..55
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409387"
     Region          58..64
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409387"
     Region          68..78
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409387"
     Region          82..88
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409387"
     Region          90..93
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409387"
     Region          100..105
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409387"
     Region          107..113
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409387"
     Region          125..132
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409387"
     Region          137..148
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409387"
     Region          158..239
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          169..173
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          182..186
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          204..208
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          218..223
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          250..337
                     /region_name="I-set"
                     /note="Immunoglobulin I-set domain; pfam07679"
                     /db_xref="CDD:400151"
     Region          266..270
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          279..283
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          303..307
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          317..322
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          330..333
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          344..427
                     /region_name="IgI_4_Neogenin_like"
                     /note="Fourth immunoglobulin (Ig)-like domain in neogenin,
                     and similar domains; member of the I-set of Ig superfamily
                     (IgSF) domains; cd05723"
                     /db_xref="CDD:409388"
     Region          344..347
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409388"
     Region          349..353
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409388"
     Region          356..365
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409388"
     Region          370..376
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409388"
     Region          378..381
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409388"
     Region          386..390
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409388"
     Region          394..398
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409388"
     Region          406..414
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409388"
     Region          417..427
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409388"
     Region          459..552
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(459,525,540)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          <522..928
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     Site            order(541..542,544..545)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          960..1055
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(1044..1045,1047..1048)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1151..1454
                     /region_name="Neogenin_C"
                     /note="Neogenin C-terminus; pfam06583"
                     /db_xref="CDD:461954"
     CDS             1..1454
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /coded_by="XM_047432587.1:284..4648"
                     /db_xref="GeneID:4756"
                     /db_xref="HGNC:HGNC:7754"
                     /db_xref="MIM:601907"
ORIGIN      
        1 maaergarrl lstpsfwlyc llllgrrapg aaaarsgsap qspgasirtf tpfyflvepv
       61 dtlsvrgssv ilncsaysep spkiewkkdg tflnlvsddr rqllpdgslf isnvvhskhn
      121 kpdegyyqcv atveslgtii srtaklivag lprftsqpep ssvyagnnai lncevnadlv
      181 pfvrweqnrq plllddrvik lpsgmlvisn ategdgglyr cvvesggppk ysdevelkvl
      241 pdpevisdlv flkqpsplvr vigqdvvlpc vasglptpti kwmkneeald tesserlvll
      301 aggsleisdv teddagtyfc iadngnetie aqaeltvqaq peflkqptni yahesmdivf
      361 ecevtgkptp tvkwvkngdm vipsdyfkiv kehnlqvlgl vksdegfyqc iaendvgnaq
      421 agaqliileh dvaiptlppt sltsattdhl apattgplps aprdvvaslv strfikltwr
      481 tpasdphgdn ltysvfytke giarervent shpgemqvti qnlmpatvyi frvmaqnkhg
      541 sgessaplrv etqpevqlpg papnlrayaa sptsitvtwe tpvsgngeiq nyklyymekg
      601 tdkeqdvdvs shsytinglk kyteysfrvv aynkhgpgvs tpdvavrtls dvpsaapqnl
      661 slevrnsksi mihwqppapa tqngqitgyk iryrkasrks dvtetlvsgt qlsqliegld
      721 rgteynfrva altingtgpa tdwlsaetfe sdldetrvpe vpsslhvrpl vtsivvswtp
      781 penqnivvrg yaigygigsp haqtikvdyk qryytienld psshyvitlk afnnvgegip
      841 lyesavtrph tvpdptpmmp pvgvqasils hdtiritwad nslpkhqkit dsryytvrwk
      901 tnipantkyk nanattlsyl vtglkpntly efsvmvtkgr rsstwsmtah gttfelvpts
      961 ppkdvtvvsk egkpktiivn wqppseangk itgyiiyyst dvnaeihdwv iepvvgnrlt
     1021 hqiqeltldt pyyfkiqarn skgmgpmsea vqfrtpkasg sggkgsrlpd lgsdykppms
     1081 gsnsphgspt spldsnmllv iivsvgviti vvvviiavfc trrttshqkk kraacksvng
     1141 shkykgnskd vkppdlwihh erlelkpidk spdpnpimtd tpiprnsqdi tpvdnsmdsn
     1201 ihqrrnsyrg hesedsmstl agrrgmrpkm mmpfdsqppq pvisahpihs ldnphhhfhs
     1261 sslasparsh lyhpgspwpi gtsmslsdra nstesvrntp stdtmpasss qtcctdhqdp
     1321 egatsssyla ssqeedsgqs lptahvrpsh plksfavpai pppgpptydp alpstpllsq
     1381 qalnhhihsv ktasigtlgr srppmpvvvp sapevqettr mledsessye pdeltkemah
     1441 leglmkdlna itta
//
LOCUS       XP_011519934            1447 aa            linear   PRI 05-AUG-2025
DEFINITION  neogenin isoform X7 [Homo sapiens].
ACCESSION   XP_011519934
VERSION     XP_011519934.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521632.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1447
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1447
                     /product="neogenin isoform X7"
                     /calculated_mol_wt=158483
     Region          52..148
                     /region_name="IgI_1_Neogenin_like"
                     /note="First immunoglobulin (Ig)-like domain in neogenin,
                     and similar domains; member of the I-set of Ig superfamily
                     (IgSF) domains; cd05722"
                     /db_xref="CDD:409387"
     Region          52..55
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409387"
     Region          58..64
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409387"
     Region          68..78
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409387"
     Region          82..88
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409387"
     Region          90..93
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409387"
     Region          100..105
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409387"
     Region          107..113
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409387"
     Region          125..132
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409387"
     Region          137..148
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409387"
     Region          158..239
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          169..173
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          182..186
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          204..208
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          218..223
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          250..337
                     /region_name="I-set"
                     /note="Immunoglobulin I-set domain; pfam07679"
                     /db_xref="CDD:400151"
     Region          266..270
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          279..283
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          303..307
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          317..322
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          330..333
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          344..427
                     /region_name="IgI_4_Neogenin_like"
                     /note="Fourth immunoglobulin (Ig)-like domain in neogenin,
                     and similar domains; member of the I-set of Ig superfamily
                     (IgSF) domains; cd05723"
                     /db_xref="CDD:409388"
     Region          344..347
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409388"
     Region          349..353
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409388"
     Region          356..365
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409388"
     Region          370..376
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409388"
     Region          378..381
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409388"
     Region          386..390
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409388"
     Region          394..398
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409388"
     Region          406..414
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409388"
     Region          417..427
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409388"
     Region          459..552
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(459,525,540)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          <522..944
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     Site            order(541..542,544..545)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          976..1071
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(1060..1061,1063..1064)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1144..1447
                     /region_name="Neogenin_C"
                     /note="Neogenin C-terminus; pfam06583"
                     /db_xref="CDD:461954"
     CDS             1..1447
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /coded_by="XM_011521632.3:284..4627"
                     /db_xref="GeneID:4756"
                     /db_xref="HGNC:HGNC:7754"
                     /db_xref="MIM:601907"
ORIGIN      
        1 maaergarrl lstpsfwlyc llllgrrapg aaaarsgsap qspgasirtf tpfyflvepv
       61 dtlsvrgssv ilncsaysep spkiewkkdg tflnlvsddr rqllpdgslf isnvvhskhn
      121 kpdegyyqcv atveslgtii srtaklivag lprftsqpep ssvyagnnai lncevnadlv
      181 pfvrweqnrq plllddrvik lpsgmlvisn ategdgglyr cvvesggppk ysdevelkvl
      241 pdpevisdlv flkqpsplvr vigqdvvlpc vasglptpti kwmkneeald tesserlvll
      301 aggsleisdv teddagtyfc iadngnetie aqaeltvqaq peflkqptni yahesmdivf
      361 ecevtgkptp tvkwvkngdm vipsdyfkiv kehnlqvlgl vksdegfyqc iaendvgnaq
      421 agaqliileh dvaiptlppt sltsattdhl apattgplps aprdvvaslv strfikltwr
      481 tpasdphgdn ltysvfytke giarervent shpgemqvti qnlmpatvyi frvmaqnkhg
      541 sgessaplrv etqpevqlpg papnlrayaa sptsitvtwe tpvsgngeiq nyklyymekg
      601 tdkeqdvdvs shsytinglk kyteysfrvv aynkhgpgvs tpdvavrtls dvpsaapqnl
      661 slevrnsksi mihwqppapa tqngqitgyk iryrkasrks dvtetlvsgt qlsqliegld
      721 rgteynfrva altingtgpa tdwlsaetfe sdldetrvpe vpsslhvrpl vtsivvswtp
      781 penqnivvrg yaigygigsp haqtikvdyk qryytienld psshyvitlk afnnvgegip
      841 lyesavtrph tdtsevdlfv inapytpvpd ptpmmppvgv qasilshdti ritwadnslp
      901 khqkitdsry ytvrwktnip antkyknana ttlsylvtgl kpntlyefsv mvtkgrrsst
      961 wsmtahgttf elvptsppkd vtvvskegkp ktiivnwqpp seangkitgy iiyystdvna
     1021 eihdwviepv vgnrlthqiq eltldtpyyf kiqarnskgm gpmseavqfr tpkgsnsphg
     1081 sptspldsnm llviivsvgv itivvvviia vfctrrttsh qkkkraacks vngshkykgn
     1141 skdvkppdlw ihherlelkp idkspdpnpi mtdtpiprns qditpvdnsm dsnihqrrns
     1201 yrghesedsm stlagrrgmr pkmmmpfdsq ppqpvisahp ihsldnphhh fhssslaspa
     1261 rshlyhpgsp wpigtsmsls dranstesvr ntpstdtmpa sssqtcctdh qdpegatsss
     1321 ylassqeeds gqslptahvr pshplksfav paipppgppt ydpalpstpl lsqqalnhhi
     1381 hsvktasigt lgrsrppmpv vvpsapevqe ttrmledses syepdeltke mahleglmkd
     1441 lnaitta
//
LOCUS       XP_047288545            1445 aa            linear   PRI 05-AUG-2025
DEFINITION  neogenin isoform X8 [Homo sapiens].
ACCESSION   XP_047288545
VERSION     XP_047288545.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432589.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1445
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1445
                     /product="neogenin isoform X8"
                     /calculated_mol_wt=158123
     Region          52..148
                     /region_name="IgI_1_Neogenin_like"
                     /note="First immunoglobulin (Ig)-like domain in neogenin,
                     and similar domains; member of the I-set of Ig superfamily
                     (IgSF) domains; cd05722"
                     /db_xref="CDD:409387"
     Region          52..55
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409387"
     Region          58..64
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409387"
     Region          68..78
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409387"
     Region          82..88
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409387"
     Region          90..93
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409387"
     Region          100..105
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409387"
     Region          107..113
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409387"
     Region          125..132
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409387"
     Region          137..148
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409387"
     Region          158..239
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          169..173
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          182..186
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          204..208
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          218..223
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          250..337
                     /region_name="I-set"
                     /note="Immunoglobulin I-set domain; pfam07679"
                     /db_xref="CDD:400151"
     Region          266..270
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          279..283
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          303..307
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          317..322
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          330..333
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          344..427
                     /region_name="IgI_4_Neogenin_like"
                     /note="Fourth immunoglobulin (Ig)-like domain in neogenin,
                     and similar domains; member of the I-set of Ig superfamily
                     (IgSF) domains; cd05723"
                     /db_xref="CDD:409388"
     Region          344..347
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409388"
     Region          349..353
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409388"
     Region          356..365
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409388"
     Region          370..376
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409388"
     Region          378..381
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409388"
     Region          386..390
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409388"
     Region          394..398
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409388"
     Region          406..414
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409388"
     Region          417..427
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409388"
     Region          439..532
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(439,505,520)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          <502..908
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     Site            order(521..522,524..525)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          940..1035
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(1024..1025,1027..1028)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1142..1445
                     /region_name="Neogenin_C"
                     /note="Neogenin C-terminus; pfam06583"
                     /db_xref="CDD:461954"
     CDS             1..1445
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /coded_by="XM_047432589.1:284..4621"
                     /db_xref="GeneID:4756"
                     /db_xref="HGNC:HGNC:7754"
                     /db_xref="MIM:601907"
ORIGIN      
        1 maaergarrl lstpsfwlyc llllgrrapg aaaarsgsap qspgasirtf tpfyflvepv
       61 dtlsvrgssv ilncsaysep spkiewkkdg tflnlvsddr rqllpdgslf isnvvhskhn
      121 kpdegyyqcv atveslgtii srtaklivag lprftsqpep ssvyagnnai lncevnadlv
      181 pfvrweqnrq plllddrvik lpsgmlvisn ategdgglyr cvvesggppk ysdevelkvl
      241 pdpevisdlv flkqpsplvr vigqdvvlpc vasglptpti kwmkneeald tesserlvll
      301 aggsleisdv teddagtyfc iadngnetie aqaeltvqaq peflkqptni yahesmdivf
      361 ecevtgkptp tvkwvkngdm vipsdyfkiv kehnlqvlgl vksdegfyqc iaendvgnaq
      421 agaqliileh apattgplps aprdvvaslv strfikltwr tpasdphgdn ltysvfytke
      481 giarervent shpgemqvti qnlmpatvyi frvmaqnkhg sgessaplrv etqpevqlpg
      541 papnlrayaa sptsitvtwe tpvsgngeiq nyklyymekg tdkeqdvdvs shsytinglk
      601 kyteysfrvv aynkhgpgvs tpdvavrtls dvpsaapqnl slevrnsksi mihwqppapa
      661 tqngqitgyk iryrkasrks dvtetlvsgt qlsqliegld rgteynfrva altingtgpa
      721 tdwlsaetfe sdldetrvpe vpsslhvrpl vtsivvswtp penqnivvrg yaigygigsp
      781 haqtikvdyk qryytienld psshyvitlk afnnvgegip lyesavtrph tvpdptpmmp
      841 pvgvqasils hdtiritwad nslpkhqkit dsryytvrwk tnipantkyk nanattlsyl
      901 vtglkpntly efsvmvtkgr rsstwsmtah gttfelvpts ppkdvtvvsk egkpktiivn
      961 wqppseangk itgyiiyyst dvnaeihdwv iepvvgnrlt hqiqeltldt pyyfkiqarn
     1021 skgmgpmsea vqfrtpkads sdkmpndqas gsggkgsrlp dlgsdykppm sgsnsphgsp
     1081 tspldsnmll viivsvgvit ivvvviiavf ctrrttshqk kkraacksvn gshkykgnsk
     1141 dvkppdlwih herlelkpid kspdpnpimt dtpiprnsqd itpvdnsmds nihqrrnsyr
     1201 ghesedsmst lagrrgmrpk mmmpfdsqpp qpvisahpih sldnphhhfh ssslaspars
     1261 hlyhpgspwp igtsmslsdr anstesvrnt pstdtmpass sqtcctdhqd pegatsssyl
     1321 assqeedsgq slptahvrps hplksfavpa ipppgpptyd palpstplls qqalnhhihs
     1381 vktasigtlg rsrppmpvvv psapevqett rmledsessy epdeltkema hleglmkdln
     1441 aitta
//
LOCUS       XP_016877720            1434 aa            linear   PRI 05-AUG-2025
DEFINITION  neogenin isoform X9 [Homo sapiens].
ACCESSION   XP_016877720
VERSION     XP_016877720.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022231.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1434
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1434
                     /product="neogenin isoform X9"
                     /calculated_mol_wt=156934
     Region          52..148
                     /region_name="IgI_1_Neogenin_like"
                     /note="First immunoglobulin (Ig)-like domain in neogenin,
                     and similar domains; member of the I-set of Ig superfamily
                     (IgSF) domains; cd05722"
                     /db_xref="CDD:409387"
     Region          52..55
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409387"
     Region          58..64
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409387"
     Region          68..78
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409387"
     Region          82..88
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409387"
     Region          90..93
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409387"
     Region          100..105
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409387"
     Region          107..113
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409387"
     Region          125..132
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409387"
     Region          137..148
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409387"
     Region          158..239
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          169..173
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          182..186
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          204..208
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          218..223
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          250..337
                     /region_name="I-set"
                     /note="Immunoglobulin I-set domain; pfam07679"
                     /db_xref="CDD:400151"
     Region          266..270
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          279..283
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          303..307
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          317..322
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          330..333
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          344..427
                     /region_name="IgI_4_Neogenin_like"
                     /note="Fourth immunoglobulin (Ig)-like domain in neogenin,
                     and similar domains; member of the I-set of Ig superfamily
                     (IgSF) domains; cd05723"
                     /db_xref="CDD:409388"
     Region          344..347
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409388"
     Region          349..353
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409388"
     Region          356..365
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409388"
     Region          370..376
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409388"
     Region          378..381
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409388"
     Region          386..390
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409388"
     Region          394..398
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409388"
     Region          406..414
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409388"
     Region          417..427
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409388"
     Region          439..532
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(439,505,520)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          <502..908
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     Site            order(521..522,524..525)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          940..1035
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(1024..1025,1027..1028)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1131..1434
                     /region_name="Neogenin_C"
                     /note="Neogenin C-terminus; pfam06583"
                     /db_xref="CDD:461954"
     CDS             1..1434
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /coded_by="XM_017022231.2:284..4588"
                     /db_xref="GeneID:4756"
                     /db_xref="HGNC:HGNC:7754"
                     /db_xref="MIM:601907"
ORIGIN      
        1 maaergarrl lstpsfwlyc llllgrrapg aaaarsgsap qspgasirtf tpfyflvepv
       61 dtlsvrgssv ilncsaysep spkiewkkdg tflnlvsddr rqllpdgslf isnvvhskhn
      121 kpdegyyqcv atveslgtii srtaklivag lprftsqpep ssvyagnnai lncevnadlv
      181 pfvrweqnrq plllddrvik lpsgmlvisn ategdgglyr cvvesggppk ysdevelkvl
      241 pdpevisdlv flkqpsplvr vigqdvvlpc vasglptpti kwmkneeald tesserlvll
      301 aggsleisdv teddagtyfc iadngnetie aqaeltvqaq peflkqptni yahesmdivf
      361 ecevtgkptp tvkwvkngdm vipsdyfkiv kehnlqvlgl vksdegfyqc iaendvgnaq
      421 agaqliileh apattgplps aprdvvaslv strfikltwr tpasdphgdn ltysvfytke
      481 giarervent shpgemqvti qnlmpatvyi frvmaqnkhg sgessaplrv etqpevqlpg
      541 papnlrayaa sptsitvtwe tpvsgngeiq nyklyymekg tdkeqdvdvs shsytinglk
      601 kyteysfrvv aynkhgpgvs tpdvavrtls dvpsaapqnl slevrnsksi mihwqppapa
      661 tqngqitgyk iryrkasrks dvtetlvsgt qlsqliegld rgteynfrva altingtgpa
      721 tdwlsaetfe sdldetrvpe vpsslhvrpl vtsivvswtp penqnivvrg yaigygigsp
      781 haqtikvdyk qryytienld psshyvitlk afnnvgegip lyesavtrph tvpdptpmmp
      841 pvgvqasils hdtiritwad nslpkhqkit dsryytvrwk tnipantkyk nanattlsyl
      901 vtglkpntly efsvmvtkgr rsstwsmtah gttfelvpts ppkdvtvvsk egkpktiivn
      961 wqppseangk itgyiiyyst dvnaeihdwv iepvvgnrlt hqiqeltldt pyyfkiqarn
     1021 skgmgpmsea vqfrtpkasg sggkgsrlpd lgsdykppms gsnsphgspt spldsnmllv
     1081 iivsvgviti vvvviiavfc trrttshqkk kraacksvng shkykgnskd vkppdlwihh
     1141 erlelkpidk spdpnpimtd tpiprnsqdi tpvdnsmdsn ihqrrnsyrg hesedsmstl
     1201 agrrgmrpkm mmpfdsqppq pvisahpihs ldnphhhfhs sslasparsh lyhpgspwpi
     1261 gtsmslsdra nstesvrntp stdtmpasss qtcctdhqdp egatsssyla ssqeedsgqs
     1321 lptahvrpsh plksfavpai pppgpptydp alpstpllsq qalnhhihsv ktasigtlgr
     1381 srppmpvvvp sapevqettr mledsessye pdeltkemah leglmkdlna itta
//
LOCUS       XP_047288546            1431 aa            linear   PRI 05-AUG-2025
DEFINITION  neogenin isoform X10 [Homo sapiens].
ACCESSION   XP_047288546
VERSION     XP_047288546.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432590.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1431
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1431
                     /product="neogenin isoform X10"
                     /calculated_mol_wt=156720
     Region          52..148
                     /region_name="IgI_1_Neogenin_like"
                     /note="First immunoglobulin (Ig)-like domain in neogenin,
                     and similar domains; member of the I-set of Ig superfamily
                     (IgSF) domains; cd05722"
                     /db_xref="CDD:409387"
     Region          52..55
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409387"
     Region          58..64
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409387"
     Region          68..78
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409387"
     Region          82..88
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409387"
     Region          90..93
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409387"
     Region          100..105
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409387"
     Region          107..113
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409387"
     Region          125..132
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409387"
     Region          137..148
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409387"
     Region          158..239
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          169..173
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          182..186
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          204..208
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          218..223
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          250..337
                     /region_name="I-set"
                     /note="Immunoglobulin I-set domain; pfam07679"
                     /db_xref="CDD:400151"
     Region          266..270
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          279..283
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          303..307
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          317..322
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          330..333
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          344..427
                     /region_name="IgI_4_Neogenin_like"
                     /note="Fourth immunoglobulin (Ig)-like domain in neogenin,
                     and similar domains; member of the I-set of Ig superfamily
                     (IgSF) domains; cd05723"
                     /db_xref="CDD:409388"
     Region          344..347
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409388"
     Region          349..353
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409388"
     Region          356..365
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409388"
     Region          370..376
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409388"
     Region          378..381
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409388"
     Region          386..390
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409388"
     Region          394..398
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409388"
     Region          406..414
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409388"
     Region          417..427
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409388"
     Region          459..552
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(459,525,540)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          <522..928
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     Site            order(541..542,544..545)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          960..1055
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(1044..1045,1047..1048)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1128..1431
                     /region_name="Neogenin_C"
                     /note="Neogenin C-terminus; pfam06583"
                     /db_xref="CDD:461954"
     CDS             1..1431
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /coded_by="XM_047432590.1:284..4579"
                     /db_xref="GeneID:4756"
                     /db_xref="HGNC:HGNC:7754"
                     /db_xref="MIM:601907"
ORIGIN      
        1 maaergarrl lstpsfwlyc llllgrrapg aaaarsgsap qspgasirtf tpfyflvepv
       61 dtlsvrgssv ilncsaysep spkiewkkdg tflnlvsddr rqllpdgslf isnvvhskhn
      121 kpdegyyqcv atveslgtii srtaklivag lprftsqpep ssvyagnnai lncevnadlv
      181 pfvrweqnrq plllddrvik lpsgmlvisn ategdgglyr cvvesggppk ysdevelkvl
      241 pdpevisdlv flkqpsplvr vigqdvvlpc vasglptpti kwmkneeald tesserlvll
      301 aggsleisdv teddagtyfc iadngnetie aqaeltvqaq peflkqptni yahesmdivf
      361 ecevtgkptp tvkwvkngdm vipsdyfkiv kehnlqvlgl vksdegfyqc iaendvgnaq
      421 agaqliileh dvaiptlppt sltsattdhl apattgplps aprdvvaslv strfikltwr
      481 tpasdphgdn ltysvfytke giarervent shpgemqvti qnlmpatvyi frvmaqnkhg
      541 sgessaplrv etqpevqlpg papnlrayaa sptsitvtwe tpvsgngeiq nyklyymekg
      601 tdkeqdvdvs shsytinglk kyteysfrvv aynkhgpgvs tpdvavrtls dvpsaapqnl
      661 slevrnsksi mihwqppapa tqngqitgyk iryrkasrks dvtetlvsgt qlsqliegld
      721 rgteynfrva altingtgpa tdwlsaetfe sdldetrvpe vpsslhvrpl vtsivvswtp
      781 penqnivvrg yaigygigsp haqtikvdyk qryytienld psshyvitlk afnnvgegip
      841 lyesavtrph tvpdptpmmp pvgvqasils hdtiritwad nslpkhqkit dsryytvrwk
      901 tnipantkyk nanattlsyl vtglkpntly efsvmvtkgr rsstwsmtah gttfelvpts
      961 ppkdvtvvsk egkpktiivn wqppseangk itgyiiyyst dvnaeihdwv iepvvgnrlt
     1021 hqiqeltldt pyyfkiqarn skgmgpmsea vqfrtpkgsn sphgsptspl dsnmllviiv
     1081 svgvitivvv viiavfctrr ttshqkkkra acksvngshk ykgnskdvkp pdlwihherl
     1141 elkpidkspd pnpimtdtpi prnsqditpv dnsmdsnihq rrnsyrghes edsmstlagr
     1201 rgmrpkmmmp fdsqppqpvi sahpihsldn phhhfhsssl asparshlyh pgspwpigts
     1261 mslsdranst esvrntpstd tmpasssqtc ctdhqdpega tsssylassq eedsgqslpt
     1321 ahvrpshplk sfavpaippp gpptydpalp stpllsqqal nhhihsvkta sigtlgrsrp
     1381 pmpvvvpsap evqettrmle dsessyepde ltkemahleg lmkdlnaitt a
//
LOCUS       XP_011519935            1428 aa            linear   PRI 05-AUG-2025
DEFINITION  neogenin isoform X11 [Homo sapiens].
ACCESSION   XP_011519935
VERSION     XP_011519935.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521633.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1428
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1428
                     /product="neogenin isoform X11"
                     /calculated_mol_wt=156205
     Region          52..148
                     /region_name="IgI_1_Neogenin_like"
                     /note="First immunoglobulin (Ig)-like domain in neogenin,
                     and similar domains; member of the I-set of Ig superfamily
                     (IgSF) domains; cd05722"
                     /db_xref="CDD:409387"
     Region          52..55
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409387"
     Region          58..64
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409387"
     Region          68..78
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409387"
     Region          82..88
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409387"
     Region          90..93
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409387"
     Region          100..105
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409387"
     Region          107..113
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409387"
     Region          125..132
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409387"
     Region          137..148
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409387"
     Region          158..239
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          169..173
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          182..186
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          204..208
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          218..223
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          250..337
                     /region_name="I-set"
                     /note="Immunoglobulin I-set domain; pfam07679"
                     /db_xref="CDD:400151"
     Region          266..270
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          279..283
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          303..307
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          317..322
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          330..333
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          344..427
                     /region_name="IgI_4_Neogenin_like"
                     /note="Fourth immunoglobulin (Ig)-like domain in neogenin,
                     and similar domains; member of the I-set of Ig superfamily
                     (IgSF) domains; cd05723"
                     /db_xref="CDD:409388"
     Region          344..347
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409388"
     Region          349..353
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409388"
     Region          356..365
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409388"
     Region          370..376
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409388"
     Region          378..381
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409388"
     Region          386..390
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409388"
     Region          394..398
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409388"
     Region          406..414
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409388"
     Region          417..427
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409388"
     Region          459..552
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(459,525,540)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          <522..944
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     Site            order(541..542,544..545)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          976..1071
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(1060..1061,1063..1064)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1178..1428
                     /region_name="Neogenin_C"
                     /note="Neogenin C-terminus; pfam06583"
                     /db_xref="CDD:461954"
     CDS             1..1428
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /coded_by="XM_011521633.4:284..4570"
                     /db_xref="GeneID:4756"
                     /db_xref="HGNC:HGNC:7754"
                     /db_xref="MIM:601907"
ORIGIN      
        1 maaergarrl lstpsfwlyc llllgrrapg aaaarsgsap qspgasirtf tpfyflvepv
       61 dtlsvrgssv ilncsaysep spkiewkkdg tflnlvsddr rqllpdgslf isnvvhskhn
      121 kpdegyyqcv atveslgtii srtaklivag lprftsqpep ssvyagnnai lncevnadlv
      181 pfvrweqnrq plllddrvik lpsgmlvisn ategdgglyr cvvesggppk ysdevelkvl
      241 pdpevisdlv flkqpsplvr vigqdvvlpc vasglptpti kwmkneeald tesserlvll
      301 aggsleisdv teddagtyfc iadngnetie aqaeltvqaq peflkqptni yahesmdivf
      361 ecevtgkptp tvkwvkngdm vipsdyfkiv kehnlqvlgl vksdegfyqc iaendvgnaq
      421 agaqliileh dvaiptlppt sltsattdhl apattgplps aprdvvaslv strfikltwr
      481 tpasdphgdn ltysvfytke giarervent shpgemqvti qnlmpatvyi frvmaqnkhg
      541 sgessaplrv etqpevqlpg papnlrayaa sptsitvtwe tpvsgngeiq nyklyymekg
      601 tdkeqdvdvs shsytinglk kyteysfrvv aynkhgpgvs tpdvavrtls dvpsaapqnl
      661 slevrnsksi mihwqppapa tqngqitgyk iryrkasrks dvtetlvsgt qlsqliegld
      721 rgteynfrva altingtgpa tdwlsaetfe sdldetrvpe vpsslhvrpl vtsivvswtp
      781 penqnivvrg yaigygigsp haqtikvdyk qryytienld psshyvitlk afnnvgegip
      841 lyesavtrph tdtsevdlfv inapytpvpd ptpmmppvgv qasilshdti ritwadnslp
      901 khqkitdsry ytvrwktnip antkyknana ttlsylvtgl kpntlyefsv mvtkgrrsst
      961 wsmtahgttf elvptsppkd vtvvskegkp ktiivnwqpp seangkitgy iiyystdvna
     1021 eihdwviepv vgnrlthqiq eltldtpyyf kiqarnskgm gpmseavqfr tpkadssdkm
     1081 pndqasgsgg kgsrlpdlgs dykppmsgsn sphgsptspl dsnmllviiv svgvitivvv
     1141 viiavfctrr ttshqkkkra acksvngshk ykgnskdvkp pdlwihherl elkpidkspd
     1201 pnpimtdtpi prnsqditpv dnsmdsnihq rrnsyrghes edsmstlagr rgmrpkmmmp
     1261 fdsqppqqsv rntpstdtmp asssqtcctd hqdpegatss sylassqeed sgqslptahv
     1321 rpshplksfa vpaipppgpp tydpalpstp llsqqalnhh ihsvktasig tlgrsrppmp
     1381 vvvpsapevq ettrmledse ssyepdeltk emahleglmk dlnaitta
//
LOCUS       XP_047288547            1454 aa            linear   PRI 05-AUG-2025
DEFINITION  neogenin isoform X5 [Homo sapiens].
ACCESSION   XP_047288547
VERSION     XP_047288547.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432591.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1454
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1454
                     /product="neogenin isoform X5"
                     /calculated_mol_wt=158966
     Region          52..148
                     /region_name="IgI_1_Neogenin_like"
                     /note="First immunoglobulin (Ig)-like domain in neogenin,
                     and similar domains; member of the I-set of Ig superfamily
                     (IgSF) domains; cd05722"
                     /db_xref="CDD:409387"
     Region          52..55
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409387"
     Region          58..64
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409387"
     Region          68..78
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409387"
     Region          82..88
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409387"
     Region          90..93
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409387"
     Region          100..105
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409387"
     Region          107..113
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409387"
     Region          125..132
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409387"
     Region          137..148
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409387"
     Region          158..239
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          169..173
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          182..186
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          204..208
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          218..223
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          250..337
                     /region_name="I-set"
                     /note="Immunoglobulin I-set domain; pfam07679"
                     /db_xref="CDD:400151"
     Region          266..270
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          279..283
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          303..307
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          317..322
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          330..333
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          344..427
                     /region_name="IgI_4_Neogenin_like"
                     /note="Fourth immunoglobulin (Ig)-like domain in neogenin,
                     and similar domains; member of the I-set of Ig superfamily
                     (IgSF) domains; cd05723"
                     /db_xref="CDD:409388"
     Region          344..347
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409388"
     Region          349..353
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409388"
     Region          356..365
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409388"
     Region          370..376
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409388"
     Region          378..381
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409388"
     Region          386..390
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409388"
     Region          394..398
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409388"
     Region          406..414
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409388"
     Region          417..427
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409388"
     Region          459..552
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(459,525,540)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          <522..928
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     Site            order(541..542,544..545)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          960..1055
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(1044..1045,1047..1048)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1151..1454
                     /region_name="Neogenin_C"
                     /note="Neogenin C-terminus; pfam06583"
                     /db_xref="CDD:461954"
     CDS             1..1454
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /coded_by="XM_047432591.1:407..4771"
                     /db_xref="GeneID:4756"
                     /db_xref="HGNC:HGNC:7754"
                     /db_xref="MIM:601907"
ORIGIN      
        1 maaergarrl lstpsfwlyc llllgrrapg aaaarsgsap qspgasirtf tpfyflvepv
       61 dtlsvrgssv ilncsaysep spkiewkkdg tflnlvsddr rqllpdgslf isnvvhskhn
      121 kpdegyyqcv atveslgtii srtaklivag lprftsqpep ssvyagnnai lncevnadlv
      181 pfvrweqnrq plllddrvik lpsgmlvisn ategdgglyr cvvesggppk ysdevelkvl
      241 pdpevisdlv flkqpsplvr vigqdvvlpc vasglptpti kwmkneeald tesserlvll
      301 aggsleisdv teddagtyfc iadngnetie aqaeltvqaq peflkqptni yahesmdivf
      361 ecevtgkptp tvkwvkngdm vipsdyfkiv kehnlqvlgl vksdegfyqc iaendvgnaq
      421 agaqliileh dvaiptlppt sltsattdhl apattgplps aprdvvaslv strfikltwr
      481 tpasdphgdn ltysvfytke giarervent shpgemqvti qnlmpatvyi frvmaqnkhg
      541 sgessaplrv etqpevqlpg papnlrayaa sptsitvtwe tpvsgngeiq nyklyymekg
      601 tdkeqdvdvs shsytinglk kyteysfrvv aynkhgpgvs tpdvavrtls dvpsaapqnl
      661 slevrnsksi mihwqppapa tqngqitgyk iryrkasrks dvtetlvsgt qlsqliegld
      721 rgteynfrva altingtgpa tdwlsaetfe sdldetrvpe vpsslhvrpl vtsivvswtp
      781 penqnivvrg yaigygigsp haqtikvdyk qryytienld psshyvitlk afnnvgegip
      841 lyesavtrph tvpdptpmmp pvgvqasils hdtiritwad nslpkhqkit dsryytvrwk
      901 tnipantkyk nanattlsyl vtglkpntly efsvmvtkgr rsstwsmtah gttfelvpts
      961 ppkdvtvvsk egkpktiivn wqppseangk itgyiiyyst dvnaeihdwv iepvvgnrlt
     1021 hqiqeltldt pyyfkiqarn skgmgpmsea vqfrtpkasg sggkgsrlpd lgsdykppms
     1081 gsnsphgspt spldsnmllv iivsvgviti vvvviiavfc trrttshqkk kraacksvng
     1141 shkykgnskd vkppdlwihh erlelkpidk spdpnpimtd tpiprnsqdi tpvdnsmdsn
     1201 ihqrrnsyrg hesedsmstl agrrgmrpkm mmpfdsqppq pvisahpihs ldnphhhfhs
     1261 sslasparsh lyhpgspwpi gtsmslsdra nstesvrntp stdtmpasss qtcctdhqdp
     1321 egatsssyla ssqeedsgqs lptahvrpsh plksfavpai pppgpptydp alpstpllsq
     1381 qalnhhihsv ktasigtlgr srppmpvvvp sapevqettr mledsessye pdeltkemah
     1441 leglmkdlna itta
//
LOCUS       XP_016877722            1417 aa            linear   PRI 05-AUG-2025
DEFINITION  neogenin isoform X12 [Homo sapiens].
ACCESSION   XP_016877722
VERSION     XP_016877722.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022233.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1417
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1417
                     /product="neogenin isoform X12"
                     /calculated_mol_wt=155016
     Region          52..148
                     /region_name="IgI_1_Neogenin_like"
                     /note="First immunoglobulin (Ig)-like domain in neogenin,
                     and similar domains; member of the I-set of Ig superfamily
                     (IgSF) domains; cd05722"
                     /db_xref="CDD:409387"
     Region          52..55
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409387"
     Region          58..64
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409387"
     Region          68..78
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409387"
     Region          82..88
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409387"
     Region          90..93
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409387"
     Region          100..105
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409387"
     Region          107..113
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409387"
     Region          125..132
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409387"
     Region          137..148
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409387"
     Region          158..239
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          169..173
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          182..186
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          204..208
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          218..223
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          250..337
                     /region_name="I-set"
                     /note="Immunoglobulin I-set domain; pfam07679"
                     /db_xref="CDD:400151"
     Region          266..270
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          279..283
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          303..307
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          317..322
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          330..333
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          344..427
                     /region_name="IgI_4_Neogenin_like"
                     /note="Fourth immunoglobulin (Ig)-like domain in neogenin,
                     and similar domains; member of the I-set of Ig superfamily
                     (IgSF) domains; cd05723"
                     /db_xref="CDD:409388"
     Region          344..347
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409388"
     Region          349..353
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409388"
     Region          356..365
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409388"
     Region          370..376
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409388"
     Region          378..381
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409388"
     Region          386..390
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409388"
     Region          394..398
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409388"
     Region          406..414
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409388"
     Region          417..427
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409388"
     Region          459..552
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(459,525,540)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          <522..944
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     Site            order(541..542,544..545)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          976..1071
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(1060..1061,1063..1064)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1167..1417
                     /region_name="Neogenin_C"
                     /note="Neogenin C-terminus; pfam06583"
                     /db_xref="CDD:461954"
     CDS             1..1417
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /coded_by="XM_017022233.2:284..4537"
                     /db_xref="GeneID:4756"
                     /db_xref="HGNC:HGNC:7754"
                     /db_xref="MIM:601907"
ORIGIN      
        1 maaergarrl lstpsfwlyc llllgrrapg aaaarsgsap qspgasirtf tpfyflvepv
       61 dtlsvrgssv ilncsaysep spkiewkkdg tflnlvsddr rqllpdgslf isnvvhskhn
      121 kpdegyyqcv atveslgtii srtaklivag lprftsqpep ssvyagnnai lncevnadlv
      181 pfvrweqnrq plllddrvik lpsgmlvisn ategdgglyr cvvesggppk ysdevelkvl
      241 pdpevisdlv flkqpsplvr vigqdvvlpc vasglptpti kwmkneeald tesserlvll
      301 aggsleisdv teddagtyfc iadngnetie aqaeltvqaq peflkqptni yahesmdivf
      361 ecevtgkptp tvkwvkngdm vipsdyfkiv kehnlqvlgl vksdegfyqc iaendvgnaq
      421 agaqliileh dvaiptlppt sltsattdhl apattgplps aprdvvaslv strfikltwr
      481 tpasdphgdn ltysvfytke giarervent shpgemqvti qnlmpatvyi frvmaqnkhg
      541 sgessaplrv etqpevqlpg papnlrayaa sptsitvtwe tpvsgngeiq nyklyymekg
      601 tdkeqdvdvs shsytinglk kyteysfrvv aynkhgpgvs tpdvavrtls dvpsaapqnl
      661 slevrnsksi mihwqppapa tqngqitgyk iryrkasrks dvtetlvsgt qlsqliegld
      721 rgteynfrva altingtgpa tdwlsaetfe sdldetrvpe vpsslhvrpl vtsivvswtp
      781 penqnivvrg yaigygigsp haqtikvdyk qryytienld psshyvitlk afnnvgegip
      841 lyesavtrph tdtsevdlfv inapytpvpd ptpmmppvgv qasilshdti ritwadnslp
      901 khqkitdsry ytvrwktnip antkyknana ttlsylvtgl kpntlyefsv mvtkgrrsst
      961 wsmtahgttf elvptsppkd vtvvskegkp ktiivnwqpp seangkitgy iiyystdvna
     1021 eihdwviepv vgnrlthqiq eltldtpyyf kiqarnskgm gpmseavqfr tpkasgsggk
     1081 gsrlpdlgsd ykppmsgsns phgsptspld snmllviivs vgvitivvvv iiavfctrrt
     1141 tshqkkkraa cksvngshky kgnskdvkpp dlwihherle lkpidkspdp npimtdtpip
     1201 rnsqditpvd nsmdsnihqr rnsyrghese dsmstlagrr gmrpkmmmpf dsqppqqsvr
     1261 ntpstdtmpa sssqtcctdh qdpegatsss ylassqeeds gqslptahvr pshplksfav
     1321 paipppgppt ydpalpstpl lsqqalnhhi hsvktasigt lgrsrppmpv vvpsapevqe
     1381 ttrmledses syepdeltke mahleglmkd lnaitta
//
LOCUS       XP_016877721            1454 aa            linear   PRI 05-AUG-2025
DEFINITION  neogenin isoform X5 [Homo sapiens].
ACCESSION   XP_016877721
VERSION     XP_016877721.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022232.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1454
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1454
                     /product="neogenin isoform X5"
                     /calculated_mol_wt=158966
     Region          52..148
                     /region_name="IgI_1_Neogenin_like"
                     /note="First immunoglobulin (Ig)-like domain in neogenin,
                     and similar domains; member of the I-set of Ig superfamily
                     (IgSF) domains; cd05722"
                     /db_xref="CDD:409387"
     Region          52..55
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409387"
     Region          58..64
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409387"
     Region          68..78
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409387"
     Region          82..88
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409387"
     Region          90..93
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409387"
     Region          100..105
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409387"
     Region          107..113
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409387"
     Region          125..132
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409387"
     Region          137..148
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409387"
     Region          158..239
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          169..173
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          182..186
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          204..208
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          218..223
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          250..337
                     /region_name="I-set"
                     /note="Immunoglobulin I-set domain; pfam07679"
                     /db_xref="CDD:400151"
     Region          266..270
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          279..283
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          303..307
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          317..322
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          330..333
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          344..427
                     /region_name="IgI_4_Neogenin_like"
                     /note="Fourth immunoglobulin (Ig)-like domain in neogenin,
                     and similar domains; member of the I-set of Ig superfamily
                     (IgSF) domains; cd05723"
                     /db_xref="CDD:409388"
     Region          344..347
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409388"
     Region          349..353
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409388"
     Region          356..365
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409388"
     Region          370..376
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409388"
     Region          378..381
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409388"
     Region          386..390
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409388"
     Region          394..398
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409388"
     Region          406..414
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409388"
     Region          417..427
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409388"
     Region          459..552
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(459,525,540)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          <522..928
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     Site            order(541..542,544..545)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          960..1055
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(1044..1045,1047..1048)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1151..1454
                     /region_name="Neogenin_C"
                     /note="Neogenin C-terminus; pfam06583"
                     /db_xref="CDD:461954"
     CDS             1..1454
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /coded_by="XM_017022232.2:256..4620"
                     /db_xref="GeneID:4756"
                     /db_xref="HGNC:HGNC:7754"
                     /db_xref="MIM:601907"
ORIGIN      
        1 maaergarrl lstpsfwlyc llllgrrapg aaaarsgsap qspgasirtf tpfyflvepv
       61 dtlsvrgssv ilncsaysep spkiewkkdg tflnlvsddr rqllpdgslf isnvvhskhn
      121 kpdegyyqcv atveslgtii srtaklivag lprftsqpep ssvyagnnai lncevnadlv
      181 pfvrweqnrq plllddrvik lpsgmlvisn ategdgglyr cvvesggppk ysdevelkvl
      241 pdpevisdlv flkqpsplvr vigqdvvlpc vasglptpti kwmkneeald tesserlvll
      301 aggsleisdv teddagtyfc iadngnetie aqaeltvqaq peflkqptni yahesmdivf
      361 ecevtgkptp tvkwvkngdm vipsdyfkiv kehnlqvlgl vksdegfyqc iaendvgnaq
      421 agaqliileh dvaiptlppt sltsattdhl apattgplps aprdvvaslv strfikltwr
      481 tpasdphgdn ltysvfytke giarervent shpgemqvti qnlmpatvyi frvmaqnkhg
      541 sgessaplrv etqpevqlpg papnlrayaa sptsitvtwe tpvsgngeiq nyklyymekg
      601 tdkeqdvdvs shsytinglk kyteysfrvv aynkhgpgvs tpdvavrtls dvpsaapqnl
      661 slevrnsksi mihwqppapa tqngqitgyk iryrkasrks dvtetlvsgt qlsqliegld
      721 rgteynfrva altingtgpa tdwlsaetfe sdldetrvpe vpsslhvrpl vtsivvswtp
      781 penqnivvrg yaigygigsp haqtikvdyk qryytienld psshyvitlk afnnvgegip
      841 lyesavtrph tvpdptpmmp pvgvqasils hdtiritwad nslpkhqkit dsryytvrwk
      901 tnipantkyk nanattlsyl vtglkpntly efsvmvtkgr rsstwsmtah gttfelvpts
      961 ppkdvtvvsk egkpktiivn wqppseangk itgyiiyyst dvnaeihdwv iepvvgnrlt
     1021 hqiqeltldt pyyfkiqarn skgmgpmsea vqfrtpkasg sggkgsrlpd lgsdykppms
     1081 gsnsphgspt spldsnmllv iivsvgviti vvvviiavfc trrttshqkk kraacksvng
     1141 shkykgnskd vkppdlwihh erlelkpidk spdpnpimtd tpiprnsqdi tpvdnsmdsn
     1201 ihqrrnsyrg hesedsmstl agrrgmrpkm mmpfdsqppq pvisahpihs ldnphhhfhs
     1261 sslasparsh lyhpgspwpi gtsmslsdra nstesvrntp stdtmpasss qtcctdhqdp
     1321 egatsssyla ssqeedsgqs lptahvrpsh plksfavpai pppgpptydp alpstpllsq
     1381 qalnhhihsv ktasigtlgr srppmpvvvp sapevqettr mledsessye pdeltkemah
     1441 leglmkdlna itta
//
LOCUS       XP_016877723            1412 aa            linear   PRI 05-AUG-2025
DEFINITION  neogenin isoform X13 [Homo sapiens].
ACCESSION   XP_016877723
VERSION     XP_016877723.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022234.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1412
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1412
                     /product="neogenin isoform X13"
                     /calculated_mol_wt=154442
     Region          52..148
                     /region_name="IgI_1_Neogenin_like"
                     /note="First immunoglobulin (Ig)-like domain in neogenin,
                     and similar domains; member of the I-set of Ig superfamily
                     (IgSF) domains; cd05722"
                     /db_xref="CDD:409387"
     Region          52..55
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409387"
     Region          58..64
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409387"
     Region          68..78
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409387"
     Region          82..88
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409387"
     Region          90..93
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409387"
     Region          100..105
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409387"
     Region          107..113
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409387"
     Region          125..132
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409387"
     Region          137..148
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409387"
     Region          158..239
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          169..173
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          182..186
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          204..208
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          218..223
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          250..337
                     /region_name="I-set"
                     /note="Immunoglobulin I-set domain; pfam07679"
                     /db_xref="CDD:400151"
     Region          266..270
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          279..283
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          303..307
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          317..322
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          330..333
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          344..427
                     /region_name="IgI_4_Neogenin_like"
                     /note="Fourth immunoglobulin (Ig)-like domain in neogenin,
                     and similar domains; member of the I-set of Ig superfamily
                     (IgSF) domains; cd05723"
                     /db_xref="CDD:409388"
     Region          344..347
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409388"
     Region          349..353
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409388"
     Region          356..365
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409388"
     Region          370..376
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409388"
     Region          378..381
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409388"
     Region          386..390
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409388"
     Region          394..398
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409388"
     Region          406..414
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409388"
     Region          417..427
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409388"
     Region          459..552
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(459,525,540)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          <522..928
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     Site            order(541..542,544..545)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          960..1055
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(1044..1045,1047..1048)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1162..1412
                     /region_name="Neogenin_C"
                     /note="Neogenin C-terminus; pfam06583"
                     /db_xref="CDD:461954"
     CDS             1..1412
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /coded_by="XM_017022234.2:284..4522"
                     /db_xref="GeneID:4756"
                     /db_xref="HGNC:HGNC:7754"
                     /db_xref="MIM:601907"
ORIGIN      
        1 maaergarrl lstpsfwlyc llllgrrapg aaaarsgsap qspgasirtf tpfyflvepv
       61 dtlsvrgssv ilncsaysep spkiewkkdg tflnlvsddr rqllpdgslf isnvvhskhn
      121 kpdegyyqcv atveslgtii srtaklivag lprftsqpep ssvyagnnai lncevnadlv
      181 pfvrweqnrq plllddrvik lpsgmlvisn ategdgglyr cvvesggppk ysdevelkvl
      241 pdpevisdlv flkqpsplvr vigqdvvlpc vasglptpti kwmkneeald tesserlvll
      301 aggsleisdv teddagtyfc iadngnetie aqaeltvqaq peflkqptni yahesmdivf
      361 ecevtgkptp tvkwvkngdm vipsdyfkiv kehnlqvlgl vksdegfyqc iaendvgnaq
      421 agaqliileh dvaiptlppt sltsattdhl apattgplps aprdvvaslv strfikltwr
      481 tpasdphgdn ltysvfytke giarervent shpgemqvti qnlmpatvyi frvmaqnkhg
      541 sgessaplrv etqpevqlpg papnlrayaa sptsitvtwe tpvsgngeiq nyklyymekg
      601 tdkeqdvdvs shsytinglk kyteysfrvv aynkhgpgvs tpdvavrtls dvpsaapqnl
      661 slevrnsksi mihwqppapa tqngqitgyk iryrkasrks dvtetlvsgt qlsqliegld
      721 rgteynfrva altingtgpa tdwlsaetfe sdldetrvpe vpsslhvrpl vtsivvswtp
      781 penqnivvrg yaigygigsp haqtikvdyk qryytienld psshyvitlk afnnvgegip
      841 lyesavtrph tvpdptpmmp pvgvqasils hdtiritwad nslpkhqkit dsryytvrwk
      901 tnipantkyk nanattlsyl vtglkpntly efsvmvtkgr rsstwsmtah gttfelvpts
      961 ppkdvtvvsk egkpktiivn wqppseangk itgyiiyyst dvnaeihdwv iepvvgnrlt
     1021 hqiqeltldt pyyfkiqarn skgmgpmsea vqfrtpkads sdkmpndqas gsggkgsrlp
     1081 dlgsdykppm sgsnsphgsp tspldsnmll viivsvgvit ivvvviiavf ctrrttshqk
     1141 kkraacksvn gshkykgnsk dvkppdlwih herlelkpid kspdpnpimt dtpiprnsqd
     1201 itpvdnsmds nihqrrnsyr ghesedsmst lagrrgmrpk mmmpfdsqpp qqsvrntpst
     1261 dtmpasssqt cctdhqdpeg atsssylass qeedsgqslp tahvrpshpl ksfavpaipp
     1321 pgpptydpal pstpllsqqa lnhhihsvkt asigtlgrsr ppmpvvvpsa pevqettrml
     1381 edsessyepd eltkemahle glmkdlnait ta
//
LOCUS       XP_047288548            1411 aa            linear   PRI 05-AUG-2025
DEFINITION  neogenin isoform X14 [Homo sapiens].
ACCESSION   XP_047288548
VERSION     XP_047288548.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432592.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1411
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1411
                     /product="neogenin isoform X14"
                     /calculated_mol_wt=154687
     Region          52..148
                     /region_name="IgI_1_Neogenin_like"
                     /note="First immunoglobulin (Ig)-like domain in neogenin,
                     and similar domains; member of the I-set of Ig superfamily
                     (IgSF) domains; cd05722"
                     /db_xref="CDD:409387"
     Region          52..55
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409387"
     Region          58..64
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409387"
     Region          68..78
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409387"
     Region          82..88
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409387"
     Region          90..93
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409387"
     Region          100..105
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409387"
     Region          107..113
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409387"
     Region          125..132
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409387"
     Region          137..148
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409387"
     Region          158..239
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          169..173
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          182..186
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          204..208
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          218..223
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          250..337
                     /region_name="I-set"
                     /note="Immunoglobulin I-set domain; pfam07679"
                     /db_xref="CDD:400151"
     Region          266..270
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          279..283
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          303..307
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          317..322
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          330..333
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          344..427
                     /region_name="IgI_4_Neogenin_like"
                     /note="Fourth immunoglobulin (Ig)-like domain in neogenin,
                     and similar domains; member of the I-set of Ig superfamily
                     (IgSF) domains; cd05723"
                     /db_xref="CDD:409388"
     Region          344..347
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409388"
     Region          349..353
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409388"
     Region          356..365
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409388"
     Region          370..376
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409388"
     Region          378..381
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409388"
     Region          386..390
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409388"
     Region          394..398
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409388"
     Region          406..414
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409388"
     Region          417..427
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409388"
     Region          439..532
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(439,505,520)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          <502..908
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     Site            order(521..522,524..525)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          940..1035
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(1024..1025,1027..1028)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1108..1411
                     /region_name="Neogenin_C"
                     /note="Neogenin C-terminus; pfam06583"
                     /db_xref="CDD:461954"
     CDS             1..1411
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /coded_by="XM_047432592.1:284..4519"
                     /db_xref="GeneID:4756"
                     /db_xref="HGNC:HGNC:7754"
                     /db_xref="MIM:601907"
ORIGIN      
        1 maaergarrl lstpsfwlyc llllgrrapg aaaarsgsap qspgasirtf tpfyflvepv
       61 dtlsvrgssv ilncsaysep spkiewkkdg tflnlvsddr rqllpdgslf isnvvhskhn
      121 kpdegyyqcv atveslgtii srtaklivag lprftsqpep ssvyagnnai lncevnadlv
      181 pfvrweqnrq plllddrvik lpsgmlvisn ategdgglyr cvvesggppk ysdevelkvl
      241 pdpevisdlv flkqpsplvr vigqdvvlpc vasglptpti kwmkneeald tesserlvll
      301 aggsleisdv teddagtyfc iadngnetie aqaeltvqaq peflkqptni yahesmdivf
      361 ecevtgkptp tvkwvkngdm vipsdyfkiv kehnlqvlgl vksdegfyqc iaendvgnaq
      421 agaqliileh apattgplps aprdvvaslv strfikltwr tpasdphgdn ltysvfytke
      481 giarervent shpgemqvti qnlmpatvyi frvmaqnkhg sgessaplrv etqpevqlpg
      541 papnlrayaa sptsitvtwe tpvsgngeiq nyklyymekg tdkeqdvdvs shsytinglk
      601 kyteysfrvv aynkhgpgvs tpdvavrtls dvpsaapqnl slevrnsksi mihwqppapa
      661 tqngqitgyk iryrkasrks dvtetlvsgt qlsqliegld rgteynfrva altingtgpa
      721 tdwlsaetfe sdldetrvpe vpsslhvrpl vtsivvswtp penqnivvrg yaigygigsp
      781 haqtikvdyk qryytienld psshyvitlk afnnvgegip lyesavtrph tvpdptpmmp
      841 pvgvqasils hdtiritwad nslpkhqkit dsryytvrwk tnipantkyk nanattlsyl
      901 vtglkpntly efsvmvtkgr rsstwsmtah gttfelvpts ppkdvtvvsk egkpktiivn
      961 wqppseangk itgyiiyyst dvnaeihdwv iepvvgnrlt hqiqeltldt pyyfkiqarn
     1021 skgmgpmsea vqfrtpkgsn sphgsptspl dsnmllviiv svgvitivvv viiavfctrr
     1081 ttshqkkkra acksvngshk ykgnskdvkp pdlwihherl elkpidkspd pnpimtdtpi
     1141 prnsqditpv dnsmdsnihq rrnsyrghes edsmstlagr rgmrpkmmmp fdsqppqpvi
     1201 sahpihsldn phhhfhsssl asparshlyh pgspwpigts mslsdranst esvrntpstd
     1261 tmpasssqtc ctdhqdpega tsssylassq eedsgqslpt ahvrpshplk sfavpaippp
     1321 gpptydpalp stpllsqqal nhhihsvkta sigtlgrsrp pmpvvvpsap evqettrmle
     1381 dsessyepde ltkemahleg lmkdlnaitt a
//
LOCUS       XP_047288549            1408 aa            linear   PRI 05-AUG-2025
DEFINITION  neogenin isoform X15 [Homo sapiens].
ACCESSION   XP_047288549
VERSION     XP_047288549.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432593.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1408
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1408
                     /product="neogenin isoform X15"
                     /calculated_mol_wt=154173
     Region          52..148
                     /region_name="IgI_1_Neogenin_like"
                     /note="First immunoglobulin (Ig)-like domain in neogenin,
                     and similar domains; member of the I-set of Ig superfamily
                     (IgSF) domains; cd05722"
                     /db_xref="CDD:409387"
     Region          52..55
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409387"
     Region          58..64
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409387"
     Region          68..78
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409387"
     Region          82..88
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409387"
     Region          90..93
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409387"
     Region          100..105
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409387"
     Region          107..113
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409387"
     Region          125..132
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409387"
     Region          137..148
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409387"
     Region          158..239
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          169..173
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          182..186
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          204..208
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          218..223
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          250..337
                     /region_name="I-set"
                     /note="Immunoglobulin I-set domain; pfam07679"
                     /db_xref="CDD:400151"
     Region          266..270
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          279..283
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          303..307
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          317..322
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          330..333
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          344..427
                     /region_name="IgI_4_Neogenin_like"
                     /note="Fourth immunoglobulin (Ig)-like domain in neogenin,
                     and similar domains; member of the I-set of Ig superfamily
                     (IgSF) domains; cd05723"
                     /db_xref="CDD:409388"
     Region          344..347
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409388"
     Region          349..353
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409388"
     Region          356..365
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409388"
     Region          370..376
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409388"
     Region          378..381
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409388"
     Region          386..390
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409388"
     Region          394..398
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409388"
     Region          406..414
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409388"
     Region          417..427
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409388"
     Region          439..532
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(439,505,520)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          <502..924
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     Site            order(521..522,524..525)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          956..1051
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(1040..1041,1043..1044)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1158..1408
                     /region_name="Neogenin_C"
                     /note="Neogenin C-terminus; pfam06583"
                     /db_xref="CDD:461954"
     CDS             1..1408
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /coded_by="XM_047432593.1:284..4510"
                     /db_xref="GeneID:4756"
                     /db_xref="HGNC:HGNC:7754"
                     /db_xref="MIM:601907"
ORIGIN      
        1 maaergarrl lstpsfwlyc llllgrrapg aaaarsgsap qspgasirtf tpfyflvepv
       61 dtlsvrgssv ilncsaysep spkiewkkdg tflnlvsddr rqllpdgslf isnvvhskhn
      121 kpdegyyqcv atveslgtii srtaklivag lprftsqpep ssvyagnnai lncevnadlv
      181 pfvrweqnrq plllddrvik lpsgmlvisn ategdgglyr cvvesggppk ysdevelkvl
      241 pdpevisdlv flkqpsplvr vigqdvvlpc vasglptpti kwmkneeald tesserlvll
      301 aggsleisdv teddagtyfc iadngnetie aqaeltvqaq peflkqptni yahesmdivf
      361 ecevtgkptp tvkwvkngdm vipsdyfkiv kehnlqvlgl vksdegfyqc iaendvgnaq
      421 agaqliileh apattgplps aprdvvaslv strfikltwr tpasdphgdn ltysvfytke
      481 giarervent shpgemqvti qnlmpatvyi frvmaqnkhg sgessaplrv etqpevqlpg
      541 papnlrayaa sptsitvtwe tpvsgngeiq nyklyymekg tdkeqdvdvs shsytinglk
      601 kyteysfrvv aynkhgpgvs tpdvavrtls dvpsaapqnl slevrnsksi mihwqppapa
      661 tqngqitgyk iryrkasrks dvtetlvsgt qlsqliegld rgteynfrva altingtgpa
      721 tdwlsaetfe sdldetrvpe vpsslhvrpl vtsivvswtp penqnivvrg yaigygigsp
      781 haqtikvdyk qryytienld psshyvitlk afnnvgegip lyesavtrph tdtsevdlfv
      841 inapytpvpd ptpmmppvgv qasilshdti ritwadnslp khqkitdsry ytvrwktnip
      901 antkyknana ttlsylvtgl kpntlyefsv mvtkgrrsst wsmtahgttf elvptsppkd
      961 vtvvskegkp ktiivnwqpp seangkitgy iiyystdvna eihdwviepv vgnrlthqiq
     1021 eltldtpyyf kiqarnskgm gpmseavqfr tpkadssdkm pndqasgsgg kgsrlpdlgs
     1081 dykppmsgsn sphgsptspl dsnmllviiv svgvitivvv viiavfctrr ttshqkkkra
     1141 acksvngshk ykgnskdvkp pdlwihherl elkpidkspd pnpimtdtpi prnsqditpv
     1201 dnsmdsnihq rrnsyrghes edsmstlagr rgmrpkmmmp fdsqppqqsv rntpstdtmp
     1261 asssqtcctd hqdpegatss sylassqeed sgqslptahv rpshplksfa vpaipppgpp
     1321 tydpalpstp llsqqalnhh ihsvktasig tlgrsrppmp vvvpsapevq ettrmledse
     1381 ssyepdeltk emahleglmk dlnaitta
//
LOCUS       XP_047288550            1445 aa            linear   PRI 05-AUG-2025
DEFINITION  neogenin isoform X8 [Homo sapiens].
ACCESSION   XP_047288550
VERSION     XP_047288550.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432594.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1445
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1445
                     /product="neogenin isoform X8"
                     /calculated_mol_wt=158123
     Region          52..148
                     /region_name="IgI_1_Neogenin_like"
                     /note="First immunoglobulin (Ig)-like domain in neogenin,
                     and similar domains; member of the I-set of Ig superfamily
                     (IgSF) domains; cd05722"
                     /db_xref="CDD:409387"
     Region          52..55
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409387"
     Region          58..64
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409387"
     Region          68..78
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409387"
     Region          82..88
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409387"
     Region          90..93
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409387"
     Region          100..105
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409387"
     Region          107..113
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409387"
     Region          125..132
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409387"
     Region          137..148
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409387"
     Region          158..239
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          169..173
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          182..186
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          204..208
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          218..223
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          250..337
                     /region_name="I-set"
                     /note="Immunoglobulin I-set domain; pfam07679"
                     /db_xref="CDD:400151"
     Region          266..270
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          279..283
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          303..307
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          317..322
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          330..333
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          344..427
                     /region_name="IgI_4_Neogenin_like"
                     /note="Fourth immunoglobulin (Ig)-like domain in neogenin,
                     and similar domains; member of the I-set of Ig superfamily
                     (IgSF) domains; cd05723"
                     /db_xref="CDD:409388"
     Region          344..347
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409388"
     Region          349..353
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409388"
     Region          356..365
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409388"
     Region          370..376
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409388"
     Region          378..381
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409388"
     Region          386..390
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409388"
     Region          394..398
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409388"
     Region          406..414
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409388"
     Region          417..427
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409388"
     Region          439..532
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(439,505,520)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          <502..908
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     Site            order(521..522,524..525)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          940..1035
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(1024..1025,1027..1028)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1142..1445
                     /region_name="Neogenin_C"
                     /note="Neogenin C-terminus; pfam06583"
                     /db_xref="CDD:461954"
     CDS             1..1445
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /coded_by="XM_047432594.1:256..4593"
                     /db_xref="GeneID:4756"
                     /db_xref="HGNC:HGNC:7754"
                     /db_xref="MIM:601907"
ORIGIN      
        1 maaergarrl lstpsfwlyc llllgrrapg aaaarsgsap qspgasirtf tpfyflvepv
       61 dtlsvrgssv ilncsaysep spkiewkkdg tflnlvsddr rqllpdgslf isnvvhskhn
      121 kpdegyyqcv atveslgtii srtaklivag lprftsqpep ssvyagnnai lncevnadlv
      181 pfvrweqnrq plllddrvik lpsgmlvisn ategdgglyr cvvesggppk ysdevelkvl
      241 pdpevisdlv flkqpsplvr vigqdvvlpc vasglptpti kwmkneeald tesserlvll
      301 aggsleisdv teddagtyfc iadngnetie aqaeltvqaq peflkqptni yahesmdivf
      361 ecevtgkptp tvkwvkngdm vipsdyfkiv kehnlqvlgl vksdegfyqc iaendvgnaq
      421 agaqliileh apattgplps aprdvvaslv strfikltwr tpasdphgdn ltysvfytke
      481 giarervent shpgemqvti qnlmpatvyi frvmaqnkhg sgessaplrv etqpevqlpg
      541 papnlrayaa sptsitvtwe tpvsgngeiq nyklyymekg tdkeqdvdvs shsytinglk
      601 kyteysfrvv aynkhgpgvs tpdvavrtls dvpsaapqnl slevrnsksi mihwqppapa
      661 tqngqitgyk iryrkasrks dvtetlvsgt qlsqliegld rgteynfrva altingtgpa
      721 tdwlsaetfe sdldetrvpe vpsslhvrpl vtsivvswtp penqnivvrg yaigygigsp
      781 haqtikvdyk qryytienld psshyvitlk afnnvgegip lyesavtrph tvpdptpmmp
      841 pvgvqasils hdtiritwad nslpkhqkit dsryytvrwk tnipantkyk nanattlsyl
      901 vtglkpntly efsvmvtkgr rsstwsmtah gttfelvpts ppkdvtvvsk egkpktiivn
      961 wqppseangk itgyiiyyst dvnaeihdwv iepvvgnrlt hqiqeltldt pyyfkiqarn
     1021 skgmgpmsea vqfrtpkads sdkmpndqas gsggkgsrlp dlgsdykppm sgsnsphgsp
     1081 tspldsnmll viivsvgvit ivvvviiavf ctrrttshqk kkraacksvn gshkykgnsk
     1141 dvkppdlwih herlelkpid kspdpnpimt dtpiprnsqd itpvdnsmds nihqrrnsyr
     1201 ghesedsmst lagrrgmrpk mmmpfdsqpp qpvisahpih sldnphhhfh ssslaspars
     1261 hlyhpgspwp igtsmslsdr anstesvrnt pstdtmpass sqtcctdhqd pegatsssyl
     1321 assqeedsgq slptahvrps hplksfavpa ipppgpptyd palpstplls qqalnhhihs
     1381 vktasigtlg rsrppmpvvv psapevqett rmledsessy epdeltkema hleglmkdln
     1441 aitta
//
LOCUS       XP_047288551            1401 aa            linear   PRI 05-AUG-2025
DEFINITION  neogenin isoform X16 [Homo sapiens].
ACCESSION   XP_047288551
VERSION     XP_047288551.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432595.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1401
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1401
                     /product="neogenin isoform X16"
                     /calculated_mol_wt=153253
     Region          52..148
                     /region_name="IgI_1_Neogenin_like"
                     /note="First immunoglobulin (Ig)-like domain in neogenin,
                     and similar domains; member of the I-set of Ig superfamily
                     (IgSF) domains; cd05722"
                     /db_xref="CDD:409387"
     Region          52..55
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409387"
     Region          58..64
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409387"
     Region          68..78
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409387"
     Region          82..88
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409387"
     Region          90..93
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409387"
     Region          100..105
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409387"
     Region          107..113
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409387"
     Region          125..132
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409387"
     Region          137..148
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409387"
     Region          158..239
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          169..173
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          182..186
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          204..208
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          218..223
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          250..337
                     /region_name="I-set"
                     /note="Immunoglobulin I-set domain; pfam07679"
                     /db_xref="CDD:400151"
     Region          266..270
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          279..283
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          303..307
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          317..322
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          330..333
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          344..427
                     /region_name="IgI_4_Neogenin_like"
                     /note="Fourth immunoglobulin (Ig)-like domain in neogenin,
                     and similar domains; member of the I-set of Ig superfamily
                     (IgSF) domains; cd05723"
                     /db_xref="CDD:409388"
     Region          344..347
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409388"
     Region          349..353
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409388"
     Region          356..365
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409388"
     Region          370..376
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409388"
     Region          378..381
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409388"
     Region          386..390
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409388"
     Region          394..398
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409388"
     Region          406..414
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409388"
     Region          417..427
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409388"
     Region          459..552
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(459,525,540)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          <522..928
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     Site            order(541..542,544..545)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          960..1055
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(1044..1045,1047..1048)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1151..1401
                     /region_name="Neogenin_C"
                     /note="Neogenin C-terminus; pfam06583"
                     /db_xref="CDD:461954"
     CDS             1..1401
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /coded_by="XM_047432595.1:284..4489"
                     /db_xref="GeneID:4756"
                     /db_xref="HGNC:HGNC:7754"
                     /db_xref="MIM:601907"
ORIGIN      
        1 maaergarrl lstpsfwlyc llllgrrapg aaaarsgsap qspgasirtf tpfyflvepv
       61 dtlsvrgssv ilncsaysep spkiewkkdg tflnlvsddr rqllpdgslf isnvvhskhn
      121 kpdegyyqcv atveslgtii srtaklivag lprftsqpep ssvyagnnai lncevnadlv
      181 pfvrweqnrq plllddrvik lpsgmlvisn ategdgglyr cvvesggppk ysdevelkvl
      241 pdpevisdlv flkqpsplvr vigqdvvlpc vasglptpti kwmkneeald tesserlvll
      301 aggsleisdv teddagtyfc iadngnetie aqaeltvqaq peflkqptni yahesmdivf
      361 ecevtgkptp tvkwvkngdm vipsdyfkiv kehnlqvlgl vksdegfyqc iaendvgnaq
      421 agaqliileh dvaiptlppt sltsattdhl apattgplps aprdvvaslv strfikltwr
      481 tpasdphgdn ltysvfytke giarervent shpgemqvti qnlmpatvyi frvmaqnkhg
      541 sgessaplrv etqpevqlpg papnlrayaa sptsitvtwe tpvsgngeiq nyklyymekg
      601 tdkeqdvdvs shsytinglk kyteysfrvv aynkhgpgvs tpdvavrtls dvpsaapqnl
      661 slevrnsksi mihwqppapa tqngqitgyk iryrkasrks dvtetlvsgt qlsqliegld
      721 rgteynfrva altingtgpa tdwlsaetfe sdldetrvpe vpsslhvrpl vtsivvswtp
      781 penqnivvrg yaigygigsp haqtikvdyk qryytienld psshyvitlk afnnvgegip
      841 lyesavtrph tvpdptpmmp pvgvqasils hdtiritwad nslpkhqkit dsryytvrwk
      901 tnipantkyk nanattlsyl vtglkpntly efsvmvtkgr rsstwsmtah gttfelvpts
      961 ppkdvtvvsk egkpktiivn wqppseangk itgyiiyyst dvnaeihdwv iepvvgnrlt
     1021 hqiqeltldt pyyfkiqarn skgmgpmsea vqfrtpkasg sggkgsrlpd lgsdykppms
     1081 gsnsphgspt spldsnmllv iivsvgviti vvvviiavfc trrttshqkk kraacksvng
     1141 shkykgnskd vkppdlwihh erlelkpidk spdpnpimtd tpiprnsqdi tpvdnsmdsn
     1201 ihqrrnsyrg hesedsmstl agrrgmrpkm mmpfdsqppq qsvrntpstd tmpasssqtc
     1261 ctdhqdpega tsssylassq eedsgqslpt ahvrpshplk sfavpaippp gpptydpalp
     1321 stpllsqqal nhhihsvkta sigtlgrsrp pmpvvvpsap evqettrmle dsessyepde
     1381 ltkemahleg lmkdlnaitt a
//
LOCUS       XP_047288552            1397 aa            linear   PRI 05-AUG-2025
DEFINITION  neogenin isoform X17 [Homo sapiens].
ACCESSION   XP_047288552
VERSION     XP_047288552.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432596.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1397
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1397
                     /product="neogenin isoform X17"
                     /calculated_mol_wt=152984
     Region          52..148
                     /region_name="IgI_1_Neogenin_like"
                     /note="First immunoglobulin (Ig)-like domain in neogenin,
                     and similar domains; member of the I-set of Ig superfamily
                     (IgSF) domains; cd05722"
                     /db_xref="CDD:409387"
     Region          52..55
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409387"
     Region          58..64
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409387"
     Region          68..78
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409387"
     Region          82..88
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409387"
     Region          90..93
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409387"
     Region          100..105
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409387"
     Region          107..113
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409387"
     Region          125..132
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409387"
     Region          137..148
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409387"
     Region          158..239
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          169..173
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          182..186
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          204..208
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          218..223
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          250..337
                     /region_name="I-set"
                     /note="Immunoglobulin I-set domain; pfam07679"
                     /db_xref="CDD:400151"
     Region          266..270
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          279..283
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          303..307
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          317..322
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          330..333
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          344..427
                     /region_name="IgI_4_Neogenin_like"
                     /note="Fourth immunoglobulin (Ig)-like domain in neogenin,
                     and similar domains; member of the I-set of Ig superfamily
                     (IgSF) domains; cd05723"
                     /db_xref="CDD:409388"
     Region          344..347
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409388"
     Region          349..353
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409388"
     Region          356..365
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409388"
     Region          370..376
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409388"
     Region          378..381
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409388"
     Region          386..390
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409388"
     Region          394..398
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409388"
     Region          406..414
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409388"
     Region          417..427
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409388"
     Region          439..532
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(439,505,520)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          <502..924
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     Site            order(521..522,524..525)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          956..1051
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(1040..1041,1043..1044)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1147..1397
                     /region_name="Neogenin_C"
                     /note="Neogenin C-terminus; pfam06583"
                     /db_xref="CDD:461954"
     CDS             1..1397
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /coded_by="XM_047432596.1:284..4477"
                     /db_xref="GeneID:4756"
                     /db_xref="HGNC:HGNC:7754"
                     /db_xref="MIM:601907"
ORIGIN      
        1 maaergarrl lstpsfwlyc llllgrrapg aaaarsgsap qspgasirtf tpfyflvepv
       61 dtlsvrgssv ilncsaysep spkiewkkdg tflnlvsddr rqllpdgslf isnvvhskhn
      121 kpdegyyqcv atveslgtii srtaklivag lprftsqpep ssvyagnnai lncevnadlv
      181 pfvrweqnrq plllddrvik lpsgmlvisn ategdgglyr cvvesggppk ysdevelkvl
      241 pdpevisdlv flkqpsplvr vigqdvvlpc vasglptpti kwmkneeald tesserlvll
      301 aggsleisdv teddagtyfc iadngnetie aqaeltvqaq peflkqptni yahesmdivf
      361 ecevtgkptp tvkwvkngdm vipsdyfkiv kehnlqvlgl vksdegfyqc iaendvgnaq
      421 agaqliileh apattgplps aprdvvaslv strfikltwr tpasdphgdn ltysvfytke
      481 giarervent shpgemqvti qnlmpatvyi frvmaqnkhg sgessaplrv etqpevqlpg
      541 papnlrayaa sptsitvtwe tpvsgngeiq nyklyymekg tdkeqdvdvs shsytinglk
      601 kyteysfrvv aynkhgpgvs tpdvavrtls dvpsaapqnl slevrnsksi mihwqppapa
      661 tqngqitgyk iryrkasrks dvtetlvsgt qlsqliegld rgteynfrva altingtgpa
      721 tdwlsaetfe sdldetrvpe vpsslhvrpl vtsivvswtp penqnivvrg yaigygigsp
      781 haqtikvdyk qryytienld psshyvitlk afnnvgegip lyesavtrph tdtsevdlfv
      841 inapytpvpd ptpmmppvgv qasilshdti ritwadnslp khqkitdsry ytvrwktnip
      901 antkyknana ttlsylvtgl kpntlyefsv mvtkgrrsst wsmtahgttf elvptsppkd
      961 vtvvskegkp ktiivnwqpp seangkitgy iiyystdvna eihdwviepv vgnrlthqiq
     1021 eltldtpyyf kiqarnskgm gpmseavqfr tpkasgsggk gsrlpdlgsd ykppmsgsns
     1081 phgsptspld snmllviivs vgvitivvvv iiavfctrrt tshqkkkraa cksvngshky
     1141 kgnskdvkpp dlwihherle lkpidkspdp npimtdtpip rnsqditpvd nsmdsnihqr
     1201 rnsyrghese dsmstlagrr gmrpkmmmpf dsqppqqsvr ntpstdtmpa sssqtcctdh
     1261 qdpegatsss ylassqeeds gqslptahvr pshplksfav paipppgppt ydpalpstpl
     1321 lsqqalnhhi hsvktasigt lgrsrppmpv vvpsapevqe ttrmledses syepdeltke
     1381 mahleglmkd lnaitta
//
LOCUS       XP_047288553            1434 aa            linear   PRI 05-AUG-2025
DEFINITION  neogenin isoform X9 [Homo sapiens].
ACCESSION   XP_047288553
VERSION     XP_047288553.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432597.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1434
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1434
                     /product="neogenin isoform X9"
                     /calculated_mol_wt=156934
     Region          52..148
                     /region_name="IgI_1_Neogenin_like"
                     /note="First immunoglobulin (Ig)-like domain in neogenin,
                     and similar domains; member of the I-set of Ig superfamily
                     (IgSF) domains; cd05722"
                     /db_xref="CDD:409387"
     Region          52..55
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409387"
     Region          58..64
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409387"
     Region          68..78
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409387"
     Region          82..88
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409387"
     Region          90..93
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409387"
     Region          100..105
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409387"
     Region          107..113
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409387"
     Region          125..132
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409387"
     Region          137..148
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409387"
     Region          158..239
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          169..173
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          182..186
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          204..208
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          218..223
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          250..337
                     /region_name="I-set"
                     /note="Immunoglobulin I-set domain; pfam07679"
                     /db_xref="CDD:400151"
     Region          266..270
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          279..283
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          303..307
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          317..322
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          330..333
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          344..427
                     /region_name="IgI_4_Neogenin_like"
                     /note="Fourth immunoglobulin (Ig)-like domain in neogenin,
                     and similar domains; member of the I-set of Ig superfamily
                     (IgSF) domains; cd05723"
                     /db_xref="CDD:409388"
     Region          344..347
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409388"
     Region          349..353
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409388"
     Region          356..365
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409388"
     Region          370..376
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409388"
     Region          378..381
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409388"
     Region          386..390
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409388"
     Region          394..398
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409388"
     Region          406..414
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409388"
     Region          417..427
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409388"
     Region          439..532
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(439,505,520)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          <502..908
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     Site            order(521..522,524..525)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          940..1035
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(1024..1025,1027..1028)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1131..1434
                     /region_name="Neogenin_C"
                     /note="Neogenin C-terminus; pfam06583"
                     /db_xref="CDD:461954"
     CDS             1..1434
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /coded_by="XM_047432597.1:256..4560"
                     /db_xref="GeneID:4756"
                     /db_xref="HGNC:HGNC:7754"
                     /db_xref="MIM:601907"
ORIGIN      
        1 maaergarrl lstpsfwlyc llllgrrapg aaaarsgsap qspgasirtf tpfyflvepv
       61 dtlsvrgssv ilncsaysep spkiewkkdg tflnlvsddr rqllpdgslf isnvvhskhn
      121 kpdegyyqcv atveslgtii srtaklivag lprftsqpep ssvyagnnai lncevnadlv
      181 pfvrweqnrq plllddrvik lpsgmlvisn ategdgglyr cvvesggppk ysdevelkvl
      241 pdpevisdlv flkqpsplvr vigqdvvlpc vasglptpti kwmkneeald tesserlvll
      301 aggsleisdv teddagtyfc iadngnetie aqaeltvqaq peflkqptni yahesmdivf
      361 ecevtgkptp tvkwvkngdm vipsdyfkiv kehnlqvlgl vksdegfyqc iaendvgnaq
      421 agaqliileh apattgplps aprdvvaslv strfikltwr tpasdphgdn ltysvfytke
      481 giarervent shpgemqvti qnlmpatvyi frvmaqnkhg sgessaplrv etqpevqlpg
      541 papnlrayaa sptsitvtwe tpvsgngeiq nyklyymekg tdkeqdvdvs shsytinglk
      601 kyteysfrvv aynkhgpgvs tpdvavrtls dvpsaapqnl slevrnsksi mihwqppapa
      661 tqngqitgyk iryrkasrks dvtetlvsgt qlsqliegld rgteynfrva altingtgpa
      721 tdwlsaetfe sdldetrvpe vpsslhvrpl vtsivvswtp penqnivvrg yaigygigsp
      781 haqtikvdyk qryytienld psshyvitlk afnnvgegip lyesavtrph tvpdptpmmp
      841 pvgvqasils hdtiritwad nslpkhqkit dsryytvrwk tnipantkyk nanattlsyl
      901 vtglkpntly efsvmvtkgr rsstwsmtah gttfelvpts ppkdvtvvsk egkpktiivn
      961 wqppseangk itgyiiyyst dvnaeihdwv iepvvgnrlt hqiqeltldt pyyfkiqarn
     1021 skgmgpmsea vqfrtpkasg sggkgsrlpd lgsdykppms gsnsphgspt spldsnmllv
     1081 iivsvgviti vvvviiavfc trrttshqkk kraacksvng shkykgnskd vkppdlwihh
     1141 erlelkpidk spdpnpimtd tpiprnsqdi tpvdnsmdsn ihqrrnsyrg hesedsmstl
     1201 agrrgmrpkm mmpfdsqppq pvisahpihs ldnphhhfhs sslasparsh lyhpgspwpi
     1261 gtsmslsdra nstesvrntp stdtmpasss qtcctdhqdp egatsssyla ssqeedsgqs
     1321 lptahvrpsh plksfavpai pppgpptydp alpstpllsq qalnhhihsv ktasigtlgr
     1381 srppmpvvvp sapevqettr mledsessye pdeltkemah leglmkdlna itta
//
LOCUS       XP_016877726            1394 aa            linear   PRI 05-AUG-2025
DEFINITION  neogenin isoform X18 [Homo sapiens].
ACCESSION   XP_016877726
VERSION     XP_016877726.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022237.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1394
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1394
                     /product="neogenin isoform X18"
                     /calculated_mol_wt=152769
     Region          52..148
                     /region_name="IgI_1_Neogenin_like"
                     /note="First immunoglobulin (Ig)-like domain in neogenin,
                     and similar domains; member of the I-set of Ig superfamily
                     (IgSF) domains; cd05722"
                     /db_xref="CDD:409387"
     Region          52..55
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409387"
     Region          58..64
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409387"
     Region          68..78
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409387"
     Region          82..88
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409387"
     Region          90..93
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409387"
     Region          100..105
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409387"
     Region          107..113
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409387"
     Region          125..132
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409387"
     Region          137..148
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409387"
     Region          158..239
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          169..173
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          182..186
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          204..208
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          218..223
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          250..337
                     /region_name="I-set"
                     /note="Immunoglobulin I-set domain; pfam07679"
                     /db_xref="CDD:400151"
     Region          266..270
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          279..283
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          303..307
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          317..322
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          330..333
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          344..427
                     /region_name="IgI_4_Neogenin_like"
                     /note="Fourth immunoglobulin (Ig)-like domain in neogenin,
                     and similar domains; member of the I-set of Ig superfamily
                     (IgSF) domains; cd05723"
                     /db_xref="CDD:409388"
     Region          344..347
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409388"
     Region          349..353
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409388"
     Region          356..365
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409388"
     Region          370..376
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409388"
     Region          378..381
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409388"
     Region          386..390
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409388"
     Region          394..398
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409388"
     Region          406..414
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409388"
     Region          417..427
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409388"
     Region          459..552
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(459,525,540)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          <522..944
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     Site            order(541..542,544..545)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          976..1071
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(1060..1061,1063..1064)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1144..1394
                     /region_name="Neogenin_C"
                     /note="Neogenin C-terminus; pfam06583"
                     /db_xref="CDD:461954"
     CDS             1..1394
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /coded_by="XM_017022237.2:284..4468"
                     /db_xref="GeneID:4756"
                     /db_xref="HGNC:HGNC:7754"
                     /db_xref="MIM:601907"
ORIGIN      
        1 maaergarrl lstpsfwlyc llllgrrapg aaaarsgsap qspgasirtf tpfyflvepv
       61 dtlsvrgssv ilncsaysep spkiewkkdg tflnlvsddr rqllpdgslf isnvvhskhn
      121 kpdegyyqcv atveslgtii srtaklivag lprftsqpep ssvyagnnai lncevnadlv
      181 pfvrweqnrq plllddrvik lpsgmlvisn ategdgglyr cvvesggppk ysdevelkvl
      241 pdpevisdlv flkqpsplvr vigqdvvlpc vasglptpti kwmkneeald tesserlvll
      301 aggsleisdv teddagtyfc iadngnetie aqaeltvqaq peflkqptni yahesmdivf
      361 ecevtgkptp tvkwvkngdm vipsdyfkiv kehnlqvlgl vksdegfyqc iaendvgnaq
      421 agaqliileh dvaiptlppt sltsattdhl apattgplps aprdvvaslv strfikltwr
      481 tpasdphgdn ltysvfytke giarervent shpgemqvti qnlmpatvyi frvmaqnkhg
      541 sgessaplrv etqpevqlpg papnlrayaa sptsitvtwe tpvsgngeiq nyklyymekg
      601 tdkeqdvdvs shsytinglk kyteysfrvv aynkhgpgvs tpdvavrtls dvpsaapqnl
      661 slevrnsksi mihwqppapa tqngqitgyk iryrkasrks dvtetlvsgt qlsqliegld
      721 rgteynfrva altingtgpa tdwlsaetfe sdldetrvpe vpsslhvrpl vtsivvswtp
      781 penqnivvrg yaigygigsp haqtikvdyk qryytienld psshyvitlk afnnvgegip
      841 lyesavtrph tdtsevdlfv inapytpvpd ptpmmppvgv qasilshdti ritwadnslp
      901 khqkitdsry ytvrwktnip antkyknana ttlsylvtgl kpntlyefsv mvtkgrrsst
      961 wsmtahgttf elvptsppkd vtvvskegkp ktiivnwqpp seangkitgy iiyystdvna
     1021 eihdwviepv vgnrlthqiq eltldtpyyf kiqarnskgm gpmseavqfr tpkgsnsphg
     1081 sptspldsnm llviivsvgv itivvvviia vfctrrttsh qkkkraacks vngshkykgn
     1141 skdvkppdlw ihherlelkp idkspdpnpi mtdtpiprns qditpvdnsm dsnihqrrns
     1201 yrghesedsm stlagrrgmr pkmmmpfdsq ppqqsvrntp stdtmpasss qtcctdhqdp
     1261 egatsssyla ssqeedsgqs lptahvrpsh plksfavpai pppgpptydp alpstpllsq
     1321 qalnhhihsv ktasigtlgr srppmpvvvp sapevqettr mledsessye pdeltkemah
     1381 leglmkdlna itta
//
LOCUS       XP_047288554            1381 aa            linear   PRI 05-AUG-2025
DEFINITION  neogenin isoform X19 [Homo sapiens].
ACCESSION   XP_047288554
VERSION     XP_047288554.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432598.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1381
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1381
                     /product="neogenin isoform X19"
                     /calculated_mol_wt=151221
     Region          52..148
                     /region_name="IgI_1_Neogenin_like"
                     /note="First immunoglobulin (Ig)-like domain in neogenin,
                     and similar domains; member of the I-set of Ig superfamily
                     (IgSF) domains; cd05722"
                     /db_xref="CDD:409387"
     Region          52..55
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409387"
     Region          58..64
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409387"
     Region          68..78
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409387"
     Region          82..88
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409387"
     Region          90..93
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409387"
     Region          100..105
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409387"
     Region          107..113
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409387"
     Region          125..132
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409387"
     Region          137..148
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409387"
     Region          158..239
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          169..173
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          182..186
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          204..208
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          218..223
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          250..337
                     /region_name="I-set"
                     /note="Immunoglobulin I-set domain; pfam07679"
                     /db_xref="CDD:400151"
     Region          266..270
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          279..283
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          303..307
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          317..322
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          330..333
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          344..427
                     /region_name="IgI_4_Neogenin_like"
                     /note="Fourth immunoglobulin (Ig)-like domain in neogenin,
                     and similar domains; member of the I-set of Ig superfamily
                     (IgSF) domains; cd05723"
                     /db_xref="CDD:409388"
     Region          344..347
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409388"
     Region          349..353
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409388"
     Region          356..365
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409388"
     Region          370..376
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409388"
     Region          378..381
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409388"
     Region          386..390
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409388"
     Region          394..398
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409388"
     Region          406..414
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409388"
     Region          417..427
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409388"
     Region          439..532
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(439,505,520)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          <502..908
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     Site            order(521..522,524..525)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          940..1035
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(1024..1025,1027..1028)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1131..1381
                     /region_name="Neogenin_C"
                     /note="Neogenin C-terminus; pfam06583"
                     /db_xref="CDD:461954"
     CDS             1..1381
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /coded_by="XM_047432598.1:284..4429"
                     /db_xref="GeneID:4756"
                     /db_xref="HGNC:HGNC:7754"
                     /db_xref="MIM:601907"
ORIGIN      
        1 maaergarrl lstpsfwlyc llllgrrapg aaaarsgsap qspgasirtf tpfyflvepv
       61 dtlsvrgssv ilncsaysep spkiewkkdg tflnlvsddr rqllpdgslf isnvvhskhn
      121 kpdegyyqcv atveslgtii srtaklivag lprftsqpep ssvyagnnai lncevnadlv
      181 pfvrweqnrq plllddrvik lpsgmlvisn ategdgglyr cvvesggppk ysdevelkvl
      241 pdpevisdlv flkqpsplvr vigqdvvlpc vasglptpti kwmkneeald tesserlvll
      301 aggsleisdv teddagtyfc iadngnetie aqaeltvqaq peflkqptni yahesmdivf
      361 ecevtgkptp tvkwvkngdm vipsdyfkiv kehnlqvlgl vksdegfyqc iaendvgnaq
      421 agaqliileh apattgplps aprdvvaslv strfikltwr tpasdphgdn ltysvfytke
      481 giarervent shpgemqvti qnlmpatvyi frvmaqnkhg sgessaplrv etqpevqlpg
      541 papnlrayaa sptsitvtwe tpvsgngeiq nyklyymekg tdkeqdvdvs shsytinglk
      601 kyteysfrvv aynkhgpgvs tpdvavrtls dvpsaapqnl slevrnsksi mihwqppapa
      661 tqngqitgyk iryrkasrks dvtetlvsgt qlsqliegld rgteynfrva altingtgpa
      721 tdwlsaetfe sdldetrvpe vpsslhvrpl vtsivvswtp penqnivvrg yaigygigsp
      781 haqtikvdyk qryytienld psshyvitlk afnnvgegip lyesavtrph tvpdptpmmp
      841 pvgvqasils hdtiritwad nslpkhqkit dsryytvrwk tnipantkyk nanattlsyl
      901 vtglkpntly efsvmvtkgr rsstwsmtah gttfelvpts ppkdvtvvsk egkpktiivn
      961 wqppseangk itgyiiyyst dvnaeihdwv iepvvgnrlt hqiqeltldt pyyfkiqarn
     1021 skgmgpmsea vqfrtpkasg sggkgsrlpd lgsdykppms gsnsphgspt spldsnmllv
     1081 iivsvgviti vvvviiavfc trrttshqkk kraacksvng shkykgnskd vkppdlwihh
     1141 erlelkpidk spdpnpimtd tpiprnsqdi tpvdnsmdsn ihqrrnsyrg hesedsmstl
     1201 agrrgmrpkm mmpfdsqppq qsvrntpstd tmpasssqtc ctdhqdpega tsssylassq
     1261 eedsgqslpt ahvrpshplk sfavpaippp gpptydpalp stpllsqqal nhhihsvkta
     1321 sigtlgrsrp pmpvvvpsap evqettrmle dsessyepde ltkemahleg lmkdlnaitt
     1381 a
//
LOCUS       XP_047288555            1401 aa            linear   PRI 05-AUG-2025
DEFINITION  neogenin isoform X16 [Homo sapiens].
ACCESSION   XP_047288555
VERSION     XP_047288555.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432599.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1401
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1401
                     /product="neogenin isoform X16"
                     /calculated_mol_wt=153253
     Region          52..148
                     /region_name="IgI_1_Neogenin_like"
                     /note="First immunoglobulin (Ig)-like domain in neogenin,
                     and similar domains; member of the I-set of Ig superfamily
                     (IgSF) domains; cd05722"
                     /db_xref="CDD:409387"
     Region          52..55
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409387"
     Region          58..64
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409387"
     Region          68..78
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409387"
     Region          82..88
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409387"
     Region          90..93
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409387"
     Region          100..105
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409387"
     Region          107..113
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409387"
     Region          125..132
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409387"
     Region          137..148
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409387"
     Region          158..239
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          169..173
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          182..186
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          204..208
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          218..223
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          250..337
                     /region_name="I-set"
                     /note="Immunoglobulin I-set domain; pfam07679"
                     /db_xref="CDD:400151"
     Region          266..270
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          279..283
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          303..307
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          317..322
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          330..333
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          344..427
                     /region_name="IgI_4_Neogenin_like"
                     /note="Fourth immunoglobulin (Ig)-like domain in neogenin,
                     and similar domains; member of the I-set of Ig superfamily
                     (IgSF) domains; cd05723"
                     /db_xref="CDD:409388"
     Region          344..347
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409388"
     Region          349..353
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409388"
     Region          356..365
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409388"
     Region          370..376
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409388"
     Region          378..381
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409388"
     Region          386..390
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409388"
     Region          394..398
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409388"
     Region          406..414
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409388"
     Region          417..427
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409388"
     Region          459..552
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(459,525,540)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          <522..928
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     Site            order(541..542,544..545)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          960..1055
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(1044..1045,1047..1048)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1151..1401
                     /region_name="Neogenin_C"
                     /note="Neogenin C-terminus; pfam06583"
                     /db_xref="CDD:461954"
     CDS             1..1401
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /coded_by="XM_047432599.1:256..4461"
                     /db_xref="GeneID:4756"
                     /db_xref="HGNC:HGNC:7754"
                     /db_xref="MIM:601907"
ORIGIN      
        1 maaergarrl lstpsfwlyc llllgrrapg aaaarsgsap qspgasirtf tpfyflvepv
       61 dtlsvrgssv ilncsaysep spkiewkkdg tflnlvsddr rqllpdgslf isnvvhskhn
      121 kpdegyyqcv atveslgtii srtaklivag lprftsqpep ssvyagnnai lncevnadlv
      181 pfvrweqnrq plllddrvik lpsgmlvisn ategdgglyr cvvesggppk ysdevelkvl
      241 pdpevisdlv flkqpsplvr vigqdvvlpc vasglptpti kwmkneeald tesserlvll
      301 aggsleisdv teddagtyfc iadngnetie aqaeltvqaq peflkqptni yahesmdivf
      361 ecevtgkptp tvkwvkngdm vipsdyfkiv kehnlqvlgl vksdegfyqc iaendvgnaq
      421 agaqliileh dvaiptlppt sltsattdhl apattgplps aprdvvaslv strfikltwr
      481 tpasdphgdn ltysvfytke giarervent shpgemqvti qnlmpatvyi frvmaqnkhg
      541 sgessaplrv etqpevqlpg papnlrayaa sptsitvtwe tpvsgngeiq nyklyymekg
      601 tdkeqdvdvs shsytinglk kyteysfrvv aynkhgpgvs tpdvavrtls dvpsaapqnl
      661 slevrnsksi mihwqppapa tqngqitgyk iryrkasrks dvtetlvsgt qlsqliegld
      721 rgteynfrva altingtgpa tdwlsaetfe sdldetrvpe vpsslhvrpl vtsivvswtp
      781 penqnivvrg yaigygigsp haqtikvdyk qryytienld psshyvitlk afnnvgegip
      841 lyesavtrph tvpdptpmmp pvgvqasils hdtiritwad nslpkhqkit dsryytvrwk
      901 tnipantkyk nanattlsyl vtglkpntly efsvmvtkgr rsstwsmtah gttfelvpts
      961 ppkdvtvvsk egkpktiivn wqppseangk itgyiiyyst dvnaeihdwv iepvvgnrlt
     1021 hqiqeltldt pyyfkiqarn skgmgpmsea vqfrtpkasg sggkgsrlpd lgsdykppms
     1081 gsnsphgspt spldsnmllv iivsvgviti vvvviiavfc trrttshqkk kraacksvng
     1141 shkykgnskd vkppdlwihh erlelkpidk spdpnpimtd tpiprnsqdi tpvdnsmdsn
     1201 ihqrrnsyrg hesedsmstl agrrgmrpkm mmpfdsqppq qsvrntpstd tmpasssqtc
     1261 ctdhqdpega tsssylassq eedsgqslpt ahvrpshplk sfavpaippp gpptydpalp
     1321 stpllsqqal nhhihsvkta sigtlgrsrp pmpvvvpsap evqettrmle dsessyepde
     1381 ltkemahleg lmkdlnaitt a
//
LOCUS       XP_047288556            1358 aa            linear   PRI 05-AUG-2025
DEFINITION  neogenin isoform X20 [Homo sapiens].
ACCESSION   XP_047288556
VERSION     XP_047288556.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432600.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1358
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1358
                     /product="neogenin isoform X20"
                     /calculated_mol_wt=148974
     Region          52..148
                     /region_name="IgI_1_Neogenin_like"
                     /note="First immunoglobulin (Ig)-like domain in neogenin,
                     and similar domains; member of the I-set of Ig superfamily
                     (IgSF) domains; cd05722"
                     /db_xref="CDD:409387"
     Region          52..55
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409387"
     Region          58..64
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409387"
     Region          68..78
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409387"
     Region          82..88
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409387"
     Region          90..93
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409387"
     Region          100..105
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409387"
     Region          107..113
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409387"
     Region          125..132
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409387"
     Region          137..148
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409387"
     Region          158..239
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          169..173
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          182..186
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          204..208
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          218..223
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          250..337
                     /region_name="I-set"
                     /note="Immunoglobulin I-set domain; pfam07679"
                     /db_xref="CDD:400151"
     Region          266..270
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          279..283
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          303..307
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          317..322
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          330..333
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          344..427
                     /region_name="IgI_4_Neogenin_like"
                     /note="Fourth immunoglobulin (Ig)-like domain in neogenin,
                     and similar domains; member of the I-set of Ig superfamily
                     (IgSF) domains; cd05723"
                     /db_xref="CDD:409388"
     Region          344..347
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409388"
     Region          349..353
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409388"
     Region          356..365
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409388"
     Region          370..376
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409388"
     Region          378..381
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409388"
     Region          386..390
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409388"
     Region          394..398
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409388"
     Region          406..414
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409388"
     Region          417..427
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409388"
     Region          439..532
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(439,505,520)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          <502..908
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     Site            order(521..522,524..525)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          940..1035
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(1024..1025,1027..1028)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1108..1358
                     /region_name="Neogenin_C"
                     /note="Neogenin C-terminus; pfam06583"
                     /db_xref="CDD:461954"
     CDS             1..1358
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /coded_by="XM_047432600.1:284..4360"
                     /db_xref="GeneID:4756"
                     /db_xref="HGNC:HGNC:7754"
                     /db_xref="MIM:601907"
ORIGIN      
        1 maaergarrl lstpsfwlyc llllgrrapg aaaarsgsap qspgasirtf tpfyflvepv
       61 dtlsvrgssv ilncsaysep spkiewkkdg tflnlvsddr rqllpdgslf isnvvhskhn
      121 kpdegyyqcv atveslgtii srtaklivag lprftsqpep ssvyagnnai lncevnadlv
      181 pfvrweqnrq plllddrvik lpsgmlvisn ategdgglyr cvvesggppk ysdevelkvl
      241 pdpevisdlv flkqpsplvr vigqdvvlpc vasglptpti kwmkneeald tesserlvll
      301 aggsleisdv teddagtyfc iadngnetie aqaeltvqaq peflkqptni yahesmdivf
      361 ecevtgkptp tvkwvkngdm vipsdyfkiv kehnlqvlgl vksdegfyqc iaendvgnaq
      421 agaqliileh apattgplps aprdvvaslv strfikltwr tpasdphgdn ltysvfytke
      481 giarervent shpgemqvti qnlmpatvyi frvmaqnkhg sgessaplrv etqpevqlpg
      541 papnlrayaa sptsitvtwe tpvsgngeiq nyklyymekg tdkeqdvdvs shsytinglk
      601 kyteysfrvv aynkhgpgvs tpdvavrtls dvpsaapqnl slevrnsksi mihwqppapa
      661 tqngqitgyk iryrkasrks dvtetlvsgt qlsqliegld rgteynfrva altingtgpa
      721 tdwlsaetfe sdldetrvpe vpsslhvrpl vtsivvswtp penqnivvrg yaigygigsp
      781 haqtikvdyk qryytienld psshyvitlk afnnvgegip lyesavtrph tvpdptpmmp
      841 pvgvqasils hdtiritwad nslpkhqkit dsryytvrwk tnipantkyk nanattlsyl
      901 vtglkpntly efsvmvtkgr rsstwsmtah gttfelvpts ppkdvtvvsk egkpktiivn
      961 wqppseangk itgyiiyyst dvnaeihdwv iepvvgnrlt hqiqeltldt pyyfkiqarn
     1021 skgmgpmsea vqfrtpkgsn sphgsptspl dsnmllviiv svgvitivvv viiavfctrr
     1081 ttshqkkkra acksvngshk ykgnskdvkp pdlwihherl elkpidkspd pnpimtdtpi
     1141 prnsqditpv dnsmdsnihq rrnsyrghes edsmstlagr rgmrpkmmmp fdsqppqqsv
     1201 rntpstdtmp asssqtcctd hqdpegatss sylassqeed sgqslptahv rpshplksfa
     1261 vpaipppgpp tydpalpstp llsqqalnhh ihsvktasig tlgrsrppmp vvvpsapevq
     1321 ettrmledse ssyepdeltk emahleglmk dlnaitta
//
LOCUS       XP_047288557            1392 aa            linear   PRI 05-AUG-2025
DEFINITION  neogenin isoform X21 [Homo sapiens].
ACCESSION   XP_047288557
VERSION     XP_047288557.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432601.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1392
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1392
                     /product="neogenin isoform X21"
                     /calculated_mol_wt=152410
     Region          52..148
                     /region_name="IgI_1_Neogenin_like"
                     /note="First immunoglobulin (Ig)-like domain in neogenin,
                     and similar domains; member of the I-set of Ig superfamily
                     (IgSF) domains; cd05722"
                     /db_xref="CDD:409387"
     Region          52..55
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409387"
     Region          58..64
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409387"
     Region          68..78
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409387"
     Region          82..88
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409387"
     Region          90..93
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409387"
     Region          100..105
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409387"
     Region          107..113
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409387"
     Region          125..132
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409387"
     Region          137..148
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409387"
     Region          158..239
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          169..173
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          182..186
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          204..208
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          218..223
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          250..337
                     /region_name="I-set"
                     /note="Immunoglobulin I-set domain; pfam07679"
                     /db_xref="CDD:400151"
     Region          266..270
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          279..283
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          303..307
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          317..322
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          330..333
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          344..427
                     /region_name="IgI_4_Neogenin_like"
                     /note="Fourth immunoglobulin (Ig)-like domain in neogenin,
                     and similar domains; member of the I-set of Ig superfamily
                     (IgSF) domains; cd05723"
                     /db_xref="CDD:409388"
     Region          344..347
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409388"
     Region          349..353
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409388"
     Region          356..365
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409388"
     Region          370..376
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409388"
     Region          378..381
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409388"
     Region          386..390
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409388"
     Region          394..398
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409388"
     Region          406..414
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409388"
     Region          417..427
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409388"
     Region          439..532
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(439,505,520)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          <502..908
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     Site            order(521..522,524..525)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          940..1035
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(1024..1025,1027..1028)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1142..1392
                     /region_name="Neogenin_C"
                     /note="Neogenin C-terminus; pfam06583"
                     /db_xref="CDD:461954"
     CDS             1..1392
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /coded_by="XM_047432601.1:214..4392"
                     /db_xref="GeneID:4756"
                     /db_xref="HGNC:HGNC:7754"
                     /db_xref="MIM:601907"
ORIGIN      
        1 maaergarrl lstpsfwlyc llllgrrapg aaaarsgsap qspgasirtf tpfyflvepv
       61 dtlsvrgssv ilncsaysep spkiewkkdg tflnlvsddr rqllpdgslf isnvvhskhn
      121 kpdegyyqcv atveslgtii srtaklivag lprftsqpep ssvyagnnai lncevnadlv
      181 pfvrweqnrq plllddrvik lpsgmlvisn ategdgglyr cvvesggppk ysdevelkvl
      241 pdpevisdlv flkqpsplvr vigqdvvlpc vasglptpti kwmkneeald tesserlvll
      301 aggsleisdv teddagtyfc iadngnetie aqaeltvqaq peflkqptni yahesmdivf
      361 ecevtgkptp tvkwvkngdm vipsdyfkiv kehnlqvlgl vksdegfyqc iaendvgnaq
      421 agaqliileh apattgplps aprdvvaslv strfikltwr tpasdphgdn ltysvfytke
      481 giarervent shpgemqvti qnlmpatvyi frvmaqnkhg sgessaplrv etqpevqlpg
      541 papnlrayaa sptsitvtwe tpvsgngeiq nyklyymekg tdkeqdvdvs shsytinglk
      601 kyteysfrvv aynkhgpgvs tpdvavrtls dvpsaapqnl slevrnsksi mihwqppapa
      661 tqngqitgyk iryrkasrks dvtetlvsgt qlsqliegld rgteynfrva altingtgpa
      721 tdwlsaetfe sdldetrvpe vpsslhvrpl vtsivvswtp penqnivvrg yaigygigsp
      781 haqtikvdyk qryytienld psshyvitlk afnnvgegip lyesavtrph tvpdptpmmp
      841 pvgvqasils hdtiritwad nslpkhqkit dsryytvrwk tnipantkyk nanattlsyl
      901 vtglkpntly efsvmvtkgr rsstwsmtah gttfelvpts ppkdvtvvsk egkpktiivn
      961 wqppseangk itgyiiyyst dvnaeihdwv iepvvgnrlt hqiqeltldt pyyfkiqarn
     1021 skgmgpmsea vqfrtpkads sdkmpndqas gsggkgsrlp dlgsdykppm sgsnsphgsp
     1081 tspldsnmll viivsvgvit ivvvviiavf ctrrttshqk kkraacksvn gshkykgnsk
     1141 dvkppdlwih herlelkpid kspdpnpimt dtpiprnsqd itpvdnsmds nihqrrnsyr
     1201 ghesedsmst lagrrgmrpk mmmpfdsqpp qqsvrntpst dtmpasssqt cctdhqdpeg
     1261 atsssylass qeedsgqslp tahvrpshpl ksfavpaipp pgpptydpal pstpllsqqa
     1321 lnhhihsvkt asigtlgrsr ppmpvvvpsa pevqettrml edsessyepd eltkemahle
     1381 glmkdlnait ta
//
LOCUS       XP_016877728             145 aa            linear   PRI 05-AUG-2025
DEFINITION  neuromedin-B isoform X1 [Homo sapiens].
ACCESSION   XP_016877728
VERSION     XP_016877728.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022239.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..145
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..145
                     /product="neuromedin-B isoform X1"
                     /calculated_mol_wt=15339
     CDS             1..145
                     /gene="NMB"
                     /coded_by="XM_017022239.2:48..485"
                     /db_xref="GeneID:4828"
                     /db_xref="HGNC:HGNC:7842"
                     /db_xref="MIM:162340"
ORIGIN      
        1 marraggarm fgslllfall aagvaplswd lpeprsrask irvhsrgnlw atgasslsts
       61 ypalfrplsk qptqlaeflp gpgpshlpas cailstcsgk aegagfattq tplwllgeve
      121 aprggrlsvf plqerkrgrd eelfl
//
LOCUS       XP_016877729             825 aa            linear   PRI 05-AUG-2025
DEFINITION  NT-3 growth factor receptor isoform X1 [Homo sapiens].
ACCESSION   XP_016877729
VERSION     XP_016877729.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022240.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..825
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..825
                     /product="NT-3 growth factor receptor isoform X1"
                     /calculated_mol_wt=92671
     Region          103..160
                     /region_name="LRR_8"
                     /note="Leucine rich repeat; pfam13855"
                     /db_xref="CDD:404697"
     Region          105..128
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          129..151
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          152..164
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          163..208
                     /region_name="LRRCT_2"
                     /note="Leucine rich repeat C-terminal motif; pfam16920"
                     /db_xref="CDD:465313"
     Region          214..299
                     /region_name="ig"
                     /note="Immunoglobulin domain; pfam00047"
                     /db_xref="CDD:395002"
     Region          227..231
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409568"
     Region          240..244
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409568"
     Region          266..270
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409568"
     Region          281..286
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409568"
     Region          294..297
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409568"
     Region          304..396
                     /region_name="IgI_TrKABC_d5"
                     /note="Fifth domain (immunoglobulin-like) of Trk receptors
                     TrkA, TrkB, and TrkC; member of the I-set of Ig
                     superfamily (IgSF) domains; cd04971"
                     /db_xref="CDD:409360"
     Region          305..311
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409360"
     Region          313..316
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409360"
     Region          319..327
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409360"
     Site            328
                     /site_type="other"
                     /note="interdomain interface [polypeptide binding]"
                     /db_xref="CDD:409360"
     Region          330..337
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409360"
     Region          340..343
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409360"
     Region          348..354
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409360"
     Site            order(353,366..367,370)
                     /site_type="other"
                     /note="receptor binding site [polypeptide binding]"
                     /db_xref="CDD:409360"
     Region          358..366
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409360"
     Region          374..382
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409360"
     Region          385..393
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409360"
     Region          532..818
                     /region_name="PTKc_TrkC"
                     /note="Catalytic domain of the Protein Tyrosine Kinase,
                     Tropomyosin Related Kinase C; cd05094"
                     /db_xref="CDD:270676"
     Site            order(544..548,552,570,572,617..620,623..624,679,683..684,
                     686,697,715..719,728,762)
                     /site_type="active"
                     /db_xref="CDD:270676"
     Site            order(544..545,547..548,552,570,572,617..620,623..624,
                     683..684,686,697)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270676"
     Site            order(679,683,715..719,728,762)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270676"
     Site            696..721
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270676"
     CDS             1..825
                     /gene="NTRK3"
                     /gene_synonym="gp145(trkC); GP145-TrkC; TRKC"
                     /coded_by="XM_017022240.2:430..2907"
                     /db_xref="GeneID:4916"
                     /db_xref="HGNC:HGNC:8033"
                     /db_xref="MIM:191316"
ORIGIN      
        1 mdvslcpakc sfwrifllgs vwldyvgsvl acpancvcsk teincrrpdd gnlfpllegq
       61 dsgnsngnas initdisrni tsihienwrs lhtlnavdme lytglqklti knsglrsiqp
      121 rafaknphlr yinlssnrlt tlswqlfqtl slrelqleqn ffncscdirw mqlwqeqgea
      181 klnsqnlyci nadgsqlplf rmnisqcdlp eisvshvnlt vregdnavit cngsgsplpd
      241 vdwivtglqs inthqtnlnw tnvhainltl vnvtsedngf tltciaenvv gmsnasvalt
      301 vyypprvvsl eepelrlehc iefvvrgnpp ptlhwlhngq plreskiihv eyyqegeise
      361 gcllfnkpth ynngnytlia knplgtanqt inghflkepf pestdnfilf devsptppit
      421 vthkpeedtf gvsiavglaa facvllvvlf vminkygrrs kfgmkgpvav isgeedsasp
      481 lhhinhgitt pssldagpdt vvigmtripv ienpqyfrqg hnchkpdtyv qhikrrdivl
      541 krelgegafg kvflaecynl sptkdkmlva vkalkdptla arkdfqreae lltnlqhehi
      601 vkfygvcgdg dplimvfeym khgdlnkflr ahgpdamilv dgqprqakge lglsqmlhia
      661 sqiasgmvyl asqhfvhrdl atrnclvgan llvkigdfgm srdvystdyy rvgghtmlpi
      721 rwmppesimy rkfttesdvw sfgvilweif tygkqpwfql snteviecit qgrvlerprv
      781 cpkevydvml gcwqrepqqr lnikeiykil halgkatpiy ldilg
//
LOCUS       XP_016877730             763 aa            linear   PRI 05-AUG-2025
DEFINITION  NT-3 growth factor receptor isoform X2 [Homo sapiens].
ACCESSION   XP_016877730
VERSION     XP_016877730.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022241.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..763
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..763
                     /product="NT-3 growth factor receptor isoform X2"
                     /calculated_mol_wt=85889
     Region          41..98
                     /region_name="LRR_8"
                     /note="Leucine rich repeat; pfam13855"
                     /db_xref="CDD:404697"
     Region          43..66
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          67..89
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          101..146
                     /region_name="LRRCT_2"
                     /note="Leucine rich repeat C-terminal motif; pfam16920"
                     /db_xref="CDD:465313"
     Region          152..237
                     /region_name="ig"
                     /note="Immunoglobulin domain; pfam00047"
                     /db_xref="CDD:395002"
     Region          165..169
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          178..182
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          204..208
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          219..224
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          232..235
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          242..334
                     /region_name="IgI_TrKABC_d5"
                     /note="Fifth domain (immunoglobulin-like) of Trk receptors
                     TrkA, TrkB, and TrkC; member of the I-set of Ig
                     superfamily (IgSF) domains; cd04971"
                     /db_xref="CDD:409360"
     Region          243..249
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409360"
     Region          251..254
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409360"
     Region          257..265
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409360"
     Site            266
                     /site_type="other"
                     /note="interdomain interface [polypeptide binding]"
                     /db_xref="CDD:409360"
     Region          268..275
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409360"
     Region          278..281
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409360"
     Region          286..292
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409360"
     Site            order(291,304..305,308)
                     /site_type="other"
                     /note="receptor binding site [polypeptide binding]"
                     /db_xref="CDD:409360"
     Region          296..304
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409360"
     Region          312..320
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409360"
     Region          323..331
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409360"
     Region          470..756
                     /region_name="PTKc_TrkC"
                     /note="Catalytic domain of the Protein Tyrosine Kinase,
                     Tropomyosin Related Kinase C; cd05094"
                     /db_xref="CDD:270676"
     Site            order(482..486,490,508,510,555..558,561..562,617,621..622,
                     624,635,653..657,666,700)
                     /site_type="active"
                     /db_xref="CDD:270676"
     Site            order(482..483,485..486,490,508,510,555..558,561..562,
                     621..622,624,635)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270676"
     Site            order(617,621,653..657,666,700)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270676"
     Site            634..659
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270676"
     CDS             1..763
                     /gene="NTRK3"
                     /gene_synonym="gp145(trkC); GP145-TrkC; TRKC"
                     /coded_by="XM_017022241.2:153..2444"
                     /db_xref="GeneID:4916"
                     /db_xref="HGNC:HGNC:8033"
                     /db_xref="MIM:191316"
ORIGIN      
        1 mflsptdrvp vlpsaqgssa rhienwrslh tlnavdmely tglqkltikn sglrsiqpra
       61 faknphlryi nlssnrlttl swqlfqtlsl relqleqnff ncscdirwmq lwqeqgeakl
      121 nsqnlycina dgsqlplfrm nisqcdlpei svshvnltvr egdnavitcn gsgsplpdvd
      181 wivtglqsin thqtnlnwtn vhainltlvn vtsedngftl tciaenvvgm snasvaltvy
      241 ypprvvslee pelrlehcie fvvrgnpppt lhwlhngqpl reskiihvey yqegeisegc
      301 llfnkpthyn ngnytliakn plgtanqtin ghflkepfpe stdnfilfde vsptppitvt
      361 hkpeedtfgv siavglaafa cvllvvlfvm inkygrrskf gmkgpvavis geedsasplh
      421 hinhgittps sldagpdtvv igmtripvie npqyfrqghn chkpdtyvqh ikrrdivlkr
      481 elgegafgkv flaecynlsp tkdkmlvavk alkdptlaar kdfqreaell tnlqhehivk
      541 fygvcgdgdp limvfeymkh gdlnkflrah gpdamilvdg qprqakgelg lsqmlhiasq
      601 iasgmvylas qhfvhrdlat rnclvganll vkigdfgmsr dvystdyyrv gghtmlpirw
      661 mppesimyrk fttesdvwsf gvilweifty gkqpwfqlsn teviecitqg rvlerprvcp
      721 kevydvmlgc wqrepqqrln ikeiykilha lgkatpiyld ilg
//
LOCUS       XP_016877731             750 aa            linear   PRI 05-AUG-2025
DEFINITION  NT-3 growth factor receptor isoform X3 [Homo sapiens].
ACCESSION   XP_016877731
VERSION     XP_016877731.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022242.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..750
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..750
                     /product="NT-3 growth factor receptor isoform X3"
                     /calculated_mol_wt=83760
     Region          31..>51
                     /region_name="LRRNT"
                     /note="Leucine rich repeat N-terminal domain; pfam01462"
                     /db_xref="CDD:396168"
     Region          103..160
                     /region_name="LRR_8"
                     /note="Leucine rich repeat; pfam13855"
                     /db_xref="CDD:404697"
     Region          105..128
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          129..151
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          152..164
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          163..208
                     /region_name="LRRCT_2"
                     /note="Leucine rich repeat C-terminal motif; pfam16920"
                     /db_xref="CDD:465313"
     Region          214..299
                     /region_name="ig"
                     /note="Immunoglobulin domain; pfam00047"
                     /db_xref="CDD:395002"
     Region          227..231
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          240..244
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          266..270
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          281..286
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          294..297
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          304..396
                     /region_name="IgI_TrKABC_d5"
                     /note="Fifth domain (immunoglobulin-like) of Trk receptors
                     TrkA, TrkB, and TrkC; member of the I-set of Ig
                     superfamily (IgSF) domains; cd04971"
                     /db_xref="CDD:409360"
     Region          305..311
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409360"
     Region          313..316
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409360"
     Region          319..327
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409360"
     Site            328
                     /site_type="other"
                     /note="interdomain interface [polypeptide binding]"
                     /db_xref="CDD:409360"
     Region          330..337
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409360"
     Region          340..343
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409360"
     Region          348..354
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409360"
     Site            order(353,366..367,370)
                     /site_type="other"
                     /note="receptor binding site [polypeptide binding]"
                     /db_xref="CDD:409360"
     Region          358..366
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409360"
     Region          374..382
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409360"
     Region          385..393
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409360"
     Region          532..>711
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Site            order(544..547,550,552,570,572,601,617..620,679,683..684,
                     686,696..697)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270676"
     CDS             1..750
                     /gene="NTRK3"
                     /gene_synonym="gp145(trkC); GP145-TrkC; TRKC"
                     /coded_by="XM_017022242.3:27..2279"
                     /db_xref="GeneID:4916"
                     /db_xref="HGNC:HGNC:8033"
                     /db_xref="MIM:191316"
ORIGIN      
        1 mdvslcpakc sfwrifllgs vwldyvgsvl acpancvcsk teincrrpdd gnlfpllegq
       61 dsgnsngnas initdisrni tsihienwrs lhtlnavdme lytglqklti knsglrsiqp
      121 rafaknphlr yinlssnrlt tlswqlfqtl slrelqleqn ffncscdirw mqlwqeqgea
      181 klnsqnlyci nadgsqlplf rmnisqcdlp eisvshvnlt vregdnavit cngsgsplpd
      241 vdwivtglqs inthqtnlnw tnvhainltl vnvtsedngf tltciaenvv gmsnasvalt
      301 vyypprvvsl eepelrlehc iefvvrgnpp ptlhwlhngq plreskiihv eyyqegeise
      361 gcllfnkpth ynngnytlia knplgtanqt inghflkepf pestdnfilf devsptppit
      421 vthkpeedtf gvsiavglaa facvllvvlf vminkygrrs kfgmkgpvav isgeedsasp
      481 lhhinhgitt pssldagpdt vvigmtripv ienpqyfrqg hnchkpdtyv qhikrrdivl
      541 krelgegafg kvflaecynl sptkdkmlva vkalkdptla arkdfqreae lltnlqhehi
      601 vkfygvcgdg dplimvfeym khgdlnkflr ahgpdamilv dgqprqakge lglsqmlhia
      661 sqiasgmvyl asqhfvhrdl atrnclvgan llvkigdfgm srdvystdyy rytsakalee
      721 csdlsdrent vkdslyelip pdrfvplcyh
//
LOCUS       XP_016877733             727 aa            linear   PRI 05-AUG-2025
DEFINITION  NT-3 growth factor receptor isoform X4 [Homo sapiens].
ACCESSION   XP_016877733
VERSION     XP_016877733.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022244.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..727
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..727
                     /product="NT-3 growth factor receptor isoform X4"
                     /calculated_mol_wt=81903
     Region          5..62
                     /region_name="LRR_8"
                     /note="Leucine rich repeat; pfam13855"
                     /db_xref="CDD:404697"
     Region          7..30
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          31..53
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          65..110
                     /region_name="LRRCT_2"
                     /note="Leucine rich repeat C-terminal motif; pfam16920"
                     /db_xref="CDD:465313"
     Region          116..201
                     /region_name="ig"
                     /note="Immunoglobulin domain; pfam00047"
                     /db_xref="CDD:395002"
     Region          129..133
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          142..146
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          168..172
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          183..188
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          196..199
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          206..298
                     /region_name="IgI_TrKABC_d5"
                     /note="Fifth domain (immunoglobulin-like) of Trk receptors
                     TrkA, TrkB, and TrkC; member of the I-set of Ig
                     superfamily (IgSF) domains; cd04971"
                     /db_xref="CDD:409360"
     Region          207..213
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409360"
     Region          215..218
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409360"
     Region          221..229
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409360"
     Site            230
                     /site_type="other"
                     /note="interdomain interface [polypeptide binding]"
                     /db_xref="CDD:409360"
     Region          232..239
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409360"
     Region          242..245
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409360"
     Region          250..256
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409360"
     Site            order(255,268..269,272)
                     /site_type="other"
                     /note="receptor binding site [polypeptide binding]"
                     /db_xref="CDD:409360"
     Region          260..268
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409360"
     Region          276..284
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409360"
     Region          287..295
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409360"
     Region          434..720
                     /region_name="PTKc_TrkC"
                     /note="Catalytic domain of the Protein Tyrosine Kinase,
                     Tropomyosin Related Kinase C; cd05094"
                     /db_xref="CDD:270676"
     Site            order(446..450,454,472,474,519..522,525..526,581,585..586,
                     588,599,617..621,630,664)
                     /site_type="active"
                     /db_xref="CDD:270676"
     Site            order(446..447,449..450,454,472,474,519..522,525..526,
                     585..586,588,599)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270676"
     Site            order(581,585,617..621,630,664)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270676"
     Site            598..623
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270676"
     CDS             1..727
                     /gene="NTRK3"
                     /gene_synonym="gp145(trkC); GP145-TrkC; TRKC"
                     /coded_by="XM_017022244.3:139..2322"
                     /db_xref="GeneID:4916"
                     /db_xref="HGNC:HGNC:8033"
                     /db_xref="MIM:191316"
ORIGIN      
        1 melytglqkl tiknsglrsi qprafaknph lryinlssnr lttlswqlfq tlslrelqle
       61 qnffncscdi rwmqlwqeqg eaklnsqnly cinadgsqlp lfrmnisqcd lpeisvshvn
      121 ltvregdnav itcngsgspl pdvdwivtgl qsinthqtnl nwtnvhainl tlvnvtsedn
      181 gftltciaen vvgmsnasva ltvyypprvv sleepelrle hciefvvrgn ppptlhwlhn
      241 gqplreskii hveyyqegei segcllfnkp thynngnytl iaknplgtan qtinghflke
      301 pfpestdnfi lfdevsptpp itvthkpeed tfgvsiavgl aafacvllvv lfvminkygr
      361 rskfgmkgpv avisgeedsa splhhinhgi ttpssldagp dtvvigmtri pvienpqyfr
      421 qghnchkpdt yvqhikrrdi vlkrelgega fgkvflaecy nlsptkdkml vavkalkdpt
      481 laarkdfqre aelltnlqhe hivkfygvcg dgdplimvfe ymkhgdlnkf lrahgpdami
      541 lvdgqprqak gelglsqmlh iasqiasgmv ylasqhfvhr dlatrnclvg anllvkigdf
      601 gmsrdvystd yyrvgghtml pirwmppesi myrkfttesd vwsfgvilwe iftygkqpwf
      661 qlsnteviec itqgrvlerp rvcpkevydv mlgcwqrepq qrlnikeiyk ilhalgkatp
      721 iyldilg
//
LOCUS       XP_016877732             727 aa            linear   PRI 05-AUG-2025
DEFINITION  NT-3 growth factor receptor isoform X4 [Homo sapiens].
ACCESSION   XP_016877732
VERSION     XP_016877732.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022243.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..727
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..727
                     /product="NT-3 growth factor receptor isoform X4"
                     /calculated_mol_wt=81903
     Region          5..62
                     /region_name="LRR_8"
                     /note="Leucine rich repeat; pfam13855"
                     /db_xref="CDD:404697"
     Region          7..30
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          31..53
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          65..110
                     /region_name="LRRCT_2"
                     /note="Leucine rich repeat C-terminal motif; pfam16920"
                     /db_xref="CDD:465313"
     Region          116..201
                     /region_name="ig"
                     /note="Immunoglobulin domain; pfam00047"
                     /db_xref="CDD:395002"
     Region          129..133
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          142..146
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          168..172
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          183..188
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          196..199
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          206..298
                     /region_name="IgI_TrKABC_d5"
                     /note="Fifth domain (immunoglobulin-like) of Trk receptors
                     TrkA, TrkB, and TrkC; member of the I-set of Ig
                     superfamily (IgSF) domains; cd04971"
                     /db_xref="CDD:409360"
     Region          207..213
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409360"
     Region          215..218
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409360"
     Region          221..229
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409360"
     Site            230
                     /site_type="other"
                     /note="interdomain interface [polypeptide binding]"
                     /db_xref="CDD:409360"
     Region          232..239
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409360"
     Region          242..245
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409360"
     Region          250..256
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409360"
     Site            order(255,268..269,272)
                     /site_type="other"
                     /note="receptor binding site [polypeptide binding]"
                     /db_xref="CDD:409360"
     Region          260..268
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409360"
     Region          276..284
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409360"
     Region          287..295
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409360"
     Region          434..720
                     /region_name="PTKc_TrkC"
                     /note="Catalytic domain of the Protein Tyrosine Kinase,
                     Tropomyosin Related Kinase C; cd05094"
                     /db_xref="CDD:270676"
     Site            order(446..450,454,472,474,519..522,525..526,581,585..586,
                     588,599,617..621,630,664)
                     /site_type="active"
                     /db_xref="CDD:270676"
     Site            order(446..447,449..450,454,472,474,519..522,525..526,
                     585..586,588,599)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270676"
     Site            order(581,585,617..621,630,664)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270676"
     Site            598..623
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270676"
     CDS             1..727
                     /gene="NTRK3"
                     /gene_synonym="gp145(trkC); GP145-TrkC; TRKC"
                     /coded_by="XM_017022243.2:202..2385"
                     /db_xref="GeneID:4916"
                     /db_xref="HGNC:HGNC:8033"
                     /db_xref="MIM:191316"
ORIGIN      
        1 melytglqkl tiknsglrsi qprafaknph lryinlssnr lttlswqlfq tlslrelqle
       61 qnffncscdi rwmqlwqeqg eaklnsqnly cinadgsqlp lfrmnisqcd lpeisvshvn
      121 ltvregdnav itcngsgspl pdvdwivtgl qsinthqtnl nwtnvhainl tlvnvtsedn
      181 gftltciaen vvgmsnasva ltvyypprvv sleepelrle hciefvvrgn ppptlhwlhn
      241 gqplreskii hveyyqegei segcllfnkp thynngnytl iaknplgtan qtinghflke
      301 pfpestdnfi lfdevsptpp itvthkpeed tfgvsiavgl aafacvllvv lfvminkygr
      361 rskfgmkgpv avisgeedsa splhhinhgi ttpssldagp dtvvigmtri pvienpqyfr
      421 qghnchkpdt yvqhikrrdi vlkrelgega fgkvflaecy nlsptkdkml vavkalkdpt
      481 laarkdfqre aelltnlqhe hivkfygvcg dgdplimvfe ymkhgdlnkf lrahgpdami
      541 lvdgqprqak gelglsqmlh iasqiasgmv ylasqhfvhr dlatrnclvg anllvkigdf
      601 gmsrdvystd yyrvgghtml pirwmppesi myrkfttesd vwsfgvilwe iftygkqpwf
      661 qlsnteviec itqgrvlerp rvcpkevydv mlgcwqrepq qrlnikeiyk ilhalgkatp
      721 iyldilg
//
LOCUS       XP_016877734             727 aa            linear   PRI 05-AUG-2025
DEFINITION  NT-3 growth factor receptor isoform X4 [Homo sapiens].
ACCESSION   XP_016877734
VERSION     XP_016877734.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022245.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..727
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..727
                     /product="NT-3 growth factor receptor isoform X4"
                     /calculated_mol_wt=81903
     Region          5..62
                     /region_name="LRR_8"
                     /note="Leucine rich repeat; pfam13855"
                     /db_xref="CDD:404697"
     Region          7..30
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          31..53
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          65..110
                     /region_name="LRRCT_2"
                     /note="Leucine rich repeat C-terminal motif; pfam16920"
                     /db_xref="CDD:465313"
     Region          116..201
                     /region_name="ig"
                     /note="Immunoglobulin domain; pfam00047"
                     /db_xref="CDD:395002"
     Region          129..133
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          142..146
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          168..172
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          183..188
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          196..199
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          206..298
                     /region_name="IgI_TrKABC_d5"
                     /note="Fifth domain (immunoglobulin-like) of Trk receptors
                     TrkA, TrkB, and TrkC; member of the I-set of Ig
                     superfamily (IgSF) domains; cd04971"
                     /db_xref="CDD:409360"
     Region          207..213
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409360"
     Region          215..218
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409360"
     Region          221..229
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409360"
     Site            230
                     /site_type="other"
                     /note="interdomain interface [polypeptide binding]"
                     /db_xref="CDD:409360"
     Region          232..239
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409360"
     Region          242..245
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409360"
     Region          250..256
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409360"
     Site            order(255,268..269,272)
                     /site_type="other"
                     /note="receptor binding site [polypeptide binding]"
                     /db_xref="CDD:409360"
     Region          260..268
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409360"
     Region          276..284
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409360"
     Region          287..295
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409360"
     Region          434..720
                     /region_name="PTKc_TrkC"
                     /note="Catalytic domain of the Protein Tyrosine Kinase,
                     Tropomyosin Related Kinase C; cd05094"
                     /db_xref="CDD:270676"
     Site            order(446..450,454,472,474,519..522,525..526,581,585..586,
                     588,599,617..621,630,664)
                     /site_type="active"
                     /db_xref="CDD:270676"
     Site            order(446..447,449..450,454,472,474,519..522,525..526,
                     585..586,588,599)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270676"
     Site            order(581,585,617..621,630,664)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270676"
     Site            598..623
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270676"
     CDS             1..727
                     /gene="NTRK3"
                     /gene_synonym="gp145(trkC); GP145-TrkC; TRKC"
                     /coded_by="XM_017022245.3:194..2377"
                     /db_xref="GeneID:4916"
                     /db_xref="HGNC:HGNC:8033"
                     /db_xref="MIM:191316"
ORIGIN      
        1 melytglqkl tiknsglrsi qprafaknph lryinlssnr lttlswqlfq tlslrelqle
       61 qnffncscdi rwmqlwqeqg eaklnsqnly cinadgsqlp lfrmnisqcd lpeisvshvn
      121 ltvregdnav itcngsgspl pdvdwivtgl qsinthqtnl nwtnvhainl tlvnvtsedn
      181 gftltciaen vvgmsnasva ltvyypprvv sleepelrle hciefvvrgn ppptlhwlhn
      241 gqplreskii hveyyqegei segcllfnkp thynngnytl iaknplgtan qtinghflke
      301 pfpestdnfi lfdevsptpp itvthkpeed tfgvsiavgl aafacvllvv lfvminkygr
      361 rskfgmkgpv avisgeedsa splhhinhgi ttpssldagp dtvvigmtri pvienpqyfr
      421 qghnchkpdt yvqhikrrdi vlkrelgega fgkvflaecy nlsptkdkml vavkalkdpt
      481 laarkdfqre aelltnlqhe hivkfygvcg dgdplimvfe ymkhgdlnkf lrahgpdami
      541 lvdgqprqak gelglsqmlh iasqiasgmv ylasqhfvhr dlatrnclvg anllvkigdf
      601 gmsrdvystd yyrvgghtml pirwmppesi myrkfttesd vwsfgvilwe iftygkqpwf
      661 qlsnteviec itqgrvlerp rvcpkevydv mlgcwqrepq qrlnikeiyk ilhalgkatp
      721 iyldilg
//
LOCUS       XP_006720608             715 aa            linear   PRI 05-AUG-2025
DEFINITION  NT-3 growth factor receptor isoform X5 [Homo sapiens].
ACCESSION   XP_006720608
VERSION     XP_006720608.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720545.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..715
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..715
                     /product="NT-3 growth factor receptor isoform X5"
                     /calculated_mol_wt=79656
     Region          31..>51
                     /region_name="LRRNT"
                     /note="Leucine rich repeat N-terminal domain; pfam01462"
                     /db_xref="CDD:396168"
     Region          103..160
                     /region_name="LRR_8"
                     /note="Leucine rich repeat; pfam13855"
                     /db_xref="CDD:404697"
     Region          105..128
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          129..151
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          152..164
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          163..208
                     /region_name="LRRCT_2"
                     /note="Leucine rich repeat C-terminal motif; pfam16920"
                     /db_xref="CDD:465313"
     Region          214..299
                     /region_name="ig"
                     /note="Immunoglobulin domain; pfam00047"
                     /db_xref="CDD:395002"
     Region          227..231
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409568"
     Region          240..244
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409568"
     Region          266..270
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409568"
     Region          281..286
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409568"
     Region          294..297
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409568"
     Region          304..396
                     /region_name="IgI_TrKABC_d5"
                     /note="Fifth domain (immunoglobulin-like) of Trk receptors
                     TrkA, TrkB, and TrkC; member of the I-set of Ig
                     superfamily (IgSF) domains; cd04971"
                     /db_xref="CDD:409360"
     Region          305..311
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409360"
     Region          313..316
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409360"
     Region          319..327
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409360"
     Site            328
                     /site_type="other"
                     /note="interdomain interface [polypeptide binding]"
                     /db_xref="CDD:409360"
     Region          330..337
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409360"
     Region          340..343
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409360"
     Region          348..354
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409360"
     Site            order(353,366..367,370)
                     /site_type="other"
                     /note="receptor binding site [polypeptide binding]"
                     /db_xref="CDD:409360"
     Region          358..366
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409360"
     Region          374..382
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409360"
     Region          385..393
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409360"
     Region          532..>712
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Site            order(544..547,550,552,570,572,601,617..620,679,683..684,
                     686,696..697)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270870"
     CDS             1..715
                     /gene="NTRK3"
                     /gene_synonym="gp145(trkC); GP145-TrkC; TRKC"
                     /coded_by="XM_006720545.5:27..2174"
                     /db_xref="GeneID:4916"
                     /db_xref="HGNC:HGNC:8033"
                     /db_xref="MIM:191316"
ORIGIN      
        1 mdvslcpakc sfwrifllgs vwldyvgsvl acpancvcsk teincrrpdd gnlfpllegq
       61 dsgnsngnas initdisrni tsihienwrs lhtlnavdme lytglqklti knsglrsiqp
      121 rafaknphlr yinlssnrlt tlswqlfqtl slrelqleqn ffncscdirw mqlwqeqgea
      181 klnsqnlyci nadgsqlplf rmnisqcdlp eisvshvnlt vregdnavit cngsgsplpd
      241 vdwivtglqs inthqtnlnw tnvhainltl vnvtsedngf tltciaenvv gmsnasvalt
      301 vyypprvvsl eepelrlehc iefvvrgnpp ptlhwlhngq plreskiihv eyyqegeise
      361 gcllfnkpth ynngnytlia knplgtanqt inghflkepf pestdnfilf devsptppit
      421 vthkpeedtf gvsiavglaa facvllvvlf vminkygrrs kfgmkgpvav isgeedsasp
      481 lhhinhgitt pssldagpdt vvigmtripv ienpqyfrqg hnchkpdtyv qhikrrdivl
      541 krelgegafg kvflaecynl sptkdkmlva vkalkdptla arkdfqreae lltnlqhehi
      601 vkfygvcgdg dplimvfeym khgdlnkflr ahgpdamilv dgqprqakge lglsqmlhia
      661 sqiasgmvyl asqhfvhrdl atrnclvgan llvkigdfgm srdvystdyy rvvqa
//
LOCUS       XP_024305702             612 aa            linear   PRI 05-AUG-2025
DEFINITION  NT-3 growth factor receptor isoform X6 [Homo sapiens].
ACCESSION   XP_024305702
VERSION     XP_024305702.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449934.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..612
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..612
                     /product="NT-3 growth factor receptor isoform X6"
                     /calculated_mol_wt=68322
     Region          31..>51
                     /region_name="LRRNT"
                     /note="Leucine rich repeat N-terminal domain; pfam01462"
                     /db_xref="CDD:396168"
     Region          103..160
                     /region_name="LRR_8"
                     /note="Leucine rich repeat; pfam13855"
                     /db_xref="CDD:404697"
     Region          105..128
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          129..151
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          152..164
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          163..208
                     /region_name="LRRCT_2"
                     /note="Leucine rich repeat C-terminal motif; pfam16920"
                     /db_xref="CDD:465313"
     Region          214..299
                     /region_name="ig"
                     /note="Immunoglobulin domain; pfam00047"
                     /db_xref="CDD:395002"
     Region          227..231
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409568"
     Region          240..244
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409568"
     Region          266..270
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409568"
     Region          281..286
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409568"
     Region          294..297
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409568"
     Region          304..396
                     /region_name="IgI_TrKABC_d5"
                     /note="Fifth domain (immunoglobulin-like) of Trk receptors
                     TrkA, TrkB, and TrkC; member of the I-set of Ig
                     superfamily (IgSF) domains; cd04971"
                     /db_xref="CDD:409360"
     Region          305..311
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409360"
     Region          313..316
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409360"
     Region          319..327
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409360"
     Site            328
                     /site_type="other"
                     /note="interdomain interface [polypeptide binding]"
                     /db_xref="CDD:409360"
     Region          330..337
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409360"
     Region          340..343
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409360"
     Region          348..354
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409360"
     Site            order(353,366..367,370)
                     /site_type="other"
                     /note="receptor binding site [polypeptide binding]"
                     /db_xref="CDD:409360"
     Region          358..366
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409360"
     Region          374..382
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409360"
     Region          385..393
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409360"
     CDS             1..612
                     /gene="NTRK3"
                     /gene_synonym="gp145(trkC); GP145-TrkC; TRKC"
                     /coded_by="XM_024449934.2:430..2268"
                     /db_xref="GeneID:4916"
                     /db_xref="HGNC:HGNC:8033"
                     /db_xref="MIM:191316"
ORIGIN      
        1 mdvslcpakc sfwrifllgs vwldyvgsvl acpancvcsk teincrrpdd gnlfpllegq
       61 dsgnsngnas initdisrni tsihienwrs lhtlnavdme lytglqklti knsglrsiqp
      121 rafaknphlr yinlssnrlt tlswqlfqtl slrelqleqn ffncscdirw mqlwqeqgea
      181 klnsqnlyci nadgsqlplf rmnisqcdlp eisvshvnlt vregdnavit cngsgsplpd
      241 vdwivtglqs inthqtnlnw tnvhainltl vnvtsedngf tltciaenvv gmsnasvalt
      301 vyypprvvsl eepelrlehc iefvvrgnpp ptlhwlhngq plreskiihv eyyqegeise
      361 gcllfnkpth ynngnytlia knplgtanqt inghflkepf pestdnfilf devsptppit
      421 vthkpeedtf gvsiavglaa facvllvvlf vminkygrrs kfgmkgpvav isgeedsasp
      481 lhhinhgitt pssldagpdt vvigmtripv ienpqyfrqg hnchkpdtwv fsnidnhgil
      541 nlkdnrdhlv psthyiyeep evqsgevsyp rshgfreiml npislpghsk plnhgiyved
      601 vnvyfskgrh gf
//
LOCUS       XP_047288558             604 aa            linear   PRI 05-AUG-2025
DEFINITION  NT-3 growth factor receptor isoform X7 [Homo sapiens].
ACCESSION   XP_047288558
VERSION     XP_047288558.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432602.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..604
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..604
                     /product="NT-3 growth factor receptor isoform X7"
                     /calculated_mol_wt=67354
     Region          31..>51
                     /region_name="LRRNT"
                     /note="Leucine rich repeat N-terminal domain; pfam01462"
                     /db_xref="CDD:396168"
     Region          103..160
                     /region_name="LRR_8"
                     /note="Leucine rich repeat; pfam13855"
                     /db_xref="CDD:404697"
     Region          105..128
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          129..151
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          152..164
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          163..208
                     /region_name="LRRCT_2"
                     /note="Leucine rich repeat C-terminal motif; pfam16920"
                     /db_xref="CDD:465313"
     Region          214..299
                     /region_name="ig"
                     /note="Immunoglobulin domain; pfam00047"
                     /db_xref="CDD:395002"
     Region          227..231
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          240..244
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          266..270
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          281..286
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          294..297
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          304..396
                     /region_name="IgI_TrKABC_d5"
                     /note="Fifth domain (immunoglobulin-like) of Trk receptors
                     TrkA, TrkB, and TrkC; member of the I-set of Ig
                     superfamily (IgSF) domains; cd04971"
                     /db_xref="CDD:409360"
     Region          305..311
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409360"
     Region          313..316
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409360"
     Region          319..327
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409360"
     Site            328
                     /site_type="other"
                     /note="interdomain interface [polypeptide binding]"
                     /db_xref="CDD:409360"
     Region          330..337
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409360"
     Region          340..343
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409360"
     Region          348..354
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409360"
     Site            order(353,366..367,370)
                     /site_type="other"
                     /note="receptor binding site [polypeptide binding]"
                     /db_xref="CDD:409360"
     Region          358..366
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409360"
     Region          374..382
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409360"
     Region          385..393
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409360"
     CDS             1..604
                     /gene="NTRK3"
                     /gene_synonym="gp145(trkC); GP145-TrkC; TRKC"
                     /coded_by="XM_047432602.1:430..2244"
                     /db_xref="GeneID:4916"
                     /db_xref="HGNC:HGNC:8033"
                     /db_xref="MIM:191316"
ORIGIN      
        1 mdvslcpakc sfwrifllgs vwldyvgsvl acpancvcsk teincrrpdd gnlfpllegq
       61 dsgnsngnas initdisrni tsihienwrs lhtlnavdme lytglqklti knsglrsiqp
      121 rafaknphlr yinlssnrlt tlswqlfqtl slrelqleqn ffncscdirw mqlwqeqgea
      181 klnsqnlyci nadgsqlplf rmnisqcdlp eisvshvnlt vregdnavit cngsgsplpd
      241 vdwivtglqs inthqtnlnw tnvhainltl vnvtsedngf tltciaenvv gmsnasvalt
      301 vyypprvvsl eepelrlehc iefvvrgnpp ptlhwlhngq plreskiihv eyyqegeise
      361 gcllfnkpth ynngnytlia knplgtanqt inghflkepf pvdevsptpp itvthkpeed
      421 tfgvsiavgl aafacvllvv lfvminkygr rskfgmkgpv avisgeedsa splhhinhgi
      481 ttpssldagp dtvvigmtri pvienpqyfr qghnchkpdt wvfsnidnhg ilnlkdnrdh
      541 lvpsthyiye epevqsgevs yprshgfrei mlnpislpgh skplnhgiyv edvnvyfskg
      601 rhgf
//
LOCUS       XP_047288559             559 aa            linear   PRI 05-AUG-2025
DEFINITION  NT-3 growth factor receptor isoform X8 [Homo sapiens].
ACCESSION   XP_047288559
VERSION     XP_047288559.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432603.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..559
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..559
                     /product="NT-3 growth factor receptor isoform X8"
                     /calculated_mol_wt=62124
     Region          31..>51
                     /region_name="LRRNT"
                     /note="Leucine rich repeat N-terminal domain; pfam01462"
                     /db_xref="CDD:396168"
     Region          103..160
                     /region_name="LRR_8"
                     /note="Leucine rich repeat; pfam13855"
                     /db_xref="CDD:404697"
     Region          105..128
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          129..151
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          152..164
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          163..208
                     /region_name="LRRCT_2"
                     /note="Leucine rich repeat C-terminal motif; pfam16920"
                     /db_xref="CDD:465313"
     Region          214..299
                     /region_name="ig"
                     /note="Immunoglobulin domain; pfam00047"
                     /db_xref="CDD:395002"
     Region          227..231
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          240..244
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          266..270
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          281..286
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          294..297
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          304..396
                     /region_name="IgI_TrKABC_d5"
                     /note="Fifth domain (immunoglobulin-like) of Trk receptors
                     TrkA, TrkB, and TrkC; member of the I-set of Ig
                     superfamily (IgSF) domains; cd04971"
                     /db_xref="CDD:409360"
     Region          305..311
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409360"
     Region          313..316
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409360"
     Region          319..327
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409360"
     Site            328
                     /site_type="other"
                     /note="interdomain interface [polypeptide binding]"
                     /db_xref="CDD:409360"
     Region          330..337
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409360"
     Region          340..343
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409360"
     Region          348..354
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409360"
     Site            order(353,366..367,370)
                     /site_type="other"
                     /note="receptor binding site [polypeptide binding]"
                     /db_xref="CDD:409360"
     Region          358..366
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409360"
     Region          374..382
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409360"
     Region          385..393
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409360"
     CDS             1..559
                     /gene="NTRK3"
                     /gene_synonym="gp145(trkC); GP145-TrkC; TRKC"
                     /coded_by="XM_047432603.1:430..2109"
                     /db_xref="GeneID:4916"
                     /db_xref="HGNC:HGNC:8033"
                     /db_xref="MIM:191316"
ORIGIN      
        1 mdvslcpakc sfwrifllgs vwldyvgsvl acpancvcsk teincrrpdd gnlfpllegq
       61 dsgnsngnas initdisrni tsihienwrs lhtlnavdme lytglqklti knsglrsiqp
      121 rafaknphlr yinlssnrlt tlswqlfqtl slrelqleqn ffncscdirw mqlwqeqgea
      181 klnsqnlyci nadgsqlplf rmnisqcdlp eisvshvnlt vregdnavit cngsgsplpd
      241 vdwivtglqs inthqtnlnw tnvhainltl vnvtsedngf tltciaenvv gmsnasvalt
      301 vyypprvvsl eepelrlehc iefvvrgnpp ptlhwlhngq plreskiihv eyyqegeise
      361 gcllfnkpth ynngnytlia knplgtanqt inghflkepf pvdevsptpp itvthkpeed
      421 tfgvsiavgl aafacvllvv lfvminkygr rskfgmkgpv avisgeedsa splhhinhgi
      481 ttpssldagp dtvvigmtri pvienpqyfr qghnchkpdt cfreimlnpi slpghskpln
      541 hgiyvedvnv yfskgrhgf
//
LOCUS       XP_024305703             550 aa            linear   PRI 05-AUG-2025
DEFINITION  NT-3 growth factor receptor isoform X9 [Homo sapiens].
ACCESSION   XP_024305703
VERSION     XP_024305703.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449935.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..550
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..550
                     /product="NT-3 growth factor receptor isoform X9"
                     /calculated_mol_wt=61255
     Region          31..>51
                     /region_name="LRRNT"
                     /note="Leucine rich repeat N-terminal domain; pfam01462"
                     /db_xref="CDD:396168"
     Region          103..160
                     /region_name="LRR_8"
                     /note="Leucine rich repeat; pfam13855"
                     /db_xref="CDD:404697"
     Region          105..128
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          129..151
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          152..164
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          163..208
                     /region_name="LRRCT_2"
                     /note="Leucine rich repeat C-terminal motif; pfam16920"
                     /db_xref="CDD:465313"
     Region          214..299
                     /region_name="ig"
                     /note="Immunoglobulin domain; pfam00047"
                     /db_xref="CDD:395002"
     Region          227..231
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409568"
     Region          240..244
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409568"
     Region          266..270
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409568"
     Region          281..286
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409568"
     Region          294..297
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409568"
     Region          304..396
                     /region_name="IgI_TrKABC_d5"
                     /note="Fifth domain (immunoglobulin-like) of Trk receptors
                     TrkA, TrkB, and TrkC; member of the I-set of Ig
                     superfamily (IgSF) domains; cd04971"
                     /db_xref="CDD:409360"
     Region          305..311
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409360"
     Region          313..316
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409360"
     Region          319..327
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409360"
     Site            328
                     /site_type="other"
                     /note="interdomain interface [polypeptide binding]"
                     /db_xref="CDD:409360"
     Region          330..337
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409360"
     Region          340..343
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409360"
     Region          348..354
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409360"
     Site            order(353,366..367,370)
                     /site_type="other"
                     /note="receptor binding site [polypeptide binding]"
                     /db_xref="CDD:409360"
     Region          358..366
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409360"
     Region          374..382
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409360"
     Region          385..393
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409360"
     CDS             1..550
                     /gene="NTRK3"
                     /gene_synonym="gp145(trkC); GP145-TrkC; TRKC"
                     /coded_by="XM_024449935.2:27..1679"
                     /db_xref="GeneID:4916"
                     /db_xref="HGNC:HGNC:8033"
                     /db_xref="MIM:191316"
ORIGIN      
        1 mdvslcpakc sfwrifllgs vwldyvgsvl acpancvcsk teincrrpdd gnlfpllegq
       61 dsgnsngnas initdisrni tsihienwrs lhtlnavdme lytglqklti knsglrsiqp
      121 rafaknphlr yinlssnrlt tlswqlfqtl slrelqleqn ffncscdirw mqlwqeqgea
      181 klnsqnlyci nadgsqlplf rmnisqcdlp eisvshvnlt vregdnavit cngsgsplpd
      241 vdwivtglqs inthqtnlnw tnvhainltl vnvtsedngf tltciaenvv gmsnasvalt
      301 vyypprvvsl eepelrlehc iefvvrgnpp ptlhwlhngq plreskiihv eyyqegeise
      361 gcllfnkpth ynngnytlia knplgtanqt inghflkepf pestdnfilf devsptppit
      421 vthkpeedtf gvsiavglaa facvllvvlf vminkygrrs kfgmkgpvav isgeedsasp
      481 lhhinhgitt pssldagpdt vvigmtripv ienpqyfrqg hnchkpdtss wrlsfllvmn
      541 rnsrqqearg
//
LOCUS       XP_006720611             528 aa            linear   PRI 05-AUG-2025
DEFINITION  NT-3 growth factor receptor isoform X10 [Homo sapiens].
ACCESSION   XP_006720611
VERSION     XP_006720611.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720548.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..528
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..528
                     /product="NT-3 growth factor receptor isoform X10"
                     /calculated_mol_wt=58637
     Region          31..>51
                     /region_name="LRRNT"
                     /note="Leucine rich repeat N-terminal domain; pfam01462"
                     /db_xref="CDD:396168"
     Region          103..160
                     /region_name="LRR_8"
                     /note="Leucine rich repeat; pfam13855"
                     /db_xref="CDD:404697"
     Region          105..128
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          129..151
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          152..164
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          163..208
                     /region_name="LRRCT_2"
                     /note="Leucine rich repeat C-terminal motif; pfam16920"
                     /db_xref="CDD:465313"
     Region          214..299
                     /region_name="ig"
                     /note="Immunoglobulin domain; pfam00047"
                     /db_xref="CDD:395002"
     Region          227..231
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409568"
     Region          240..244
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409568"
     Region          266..270
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409568"
     Region          281..286
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409568"
     Region          294..297
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409568"
     Region          304..396
                     /region_name="IgI_TrKABC_d5"
                     /note="Fifth domain (immunoglobulin-like) of Trk receptors
                     TrkA, TrkB, and TrkC; member of the I-set of Ig
                     superfamily (IgSF) domains; cd04971"
                     /db_xref="CDD:409360"
     Region          305..311
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409360"
     Region          313..316
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409360"
     Region          319..327
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409360"
     Site            328
                     /site_type="other"
                     /note="interdomain interface [polypeptide binding]"
                     /db_xref="CDD:409360"
     Region          330..337
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409360"
     Region          340..343
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409360"
     Region          348..354
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409360"
     Site            order(353,366..367,370)
                     /site_type="other"
                     /note="receptor binding site [polypeptide binding]"
                     /db_xref="CDD:409360"
     Region          358..366
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409360"
     Region          374..382
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409360"
     Region          385..393
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409360"
     CDS             1..528
                     /gene="NTRK3"
                     /gene_synonym="gp145(trkC); GP145-TrkC; TRKC"
                     /coded_by="XM_006720548.5:430..2016"
                     /db_xref="GeneID:4916"
                     /db_xref="HGNC:HGNC:8033"
                     /db_xref="MIM:191316"
ORIGIN      
        1 mdvslcpakc sfwrifllgs vwldyvgsvl acpancvcsk teincrrpdd gnlfpllegq
       61 dsgnsngnas initdisrni tsihienwrs lhtlnavdme lytglqklti knsglrsiqp
      121 rafaknphlr yinlssnrlt tlswqlfqtl slrelqleqn ffncscdirw mqlwqeqgea
      181 klnsqnlyci nadgsqlplf rmnisqcdlp eisvshvnlt vregdnavit cngsgsplpd
      241 vdwivtglqs inthqtnlnw tnvhainltl vnvtsedngf tltciaenvv gmsnasvalt
      301 vyypprvvsl eepelrlehc iefvvrgnpp ptlhwlhngq plreskiihv eyyqegeise
      361 gcllfnkpth ynngnytlia knplgtanqt inghflkepf pestdnfilf devsptppit
      421 vthkpeedtf gvsiavglaa facvllvvlf vminkygrrs kfgmkgpvav isgeedsasp
      481 lhhinhgitt pssldagpdt vvigmtripv ienpqyfrqg hnchkpdt
//
LOCUS       XP_006720612             503 aa            linear   PRI 05-AUG-2025
DEFINITION  NT-3 growth factor receptor isoform X11 [Homo sapiens].
ACCESSION   XP_006720612
VERSION     XP_006720612.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720549.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..503
                     /product="NT-3 growth factor receptor isoform X11"
                     /calculated_mol_wt=56111
     Region          31..>51
                     /region_name="LRRNT"
                     /note="Leucine rich repeat N-terminal domain; pfam01462"
                     /db_xref="CDD:396168"
     Region          103..160
                     /region_name="LRR_8"
                     /note="Leucine rich repeat; pfam13855"
                     /db_xref="CDD:404697"
     Region          105..128
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          129..151
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          152..164
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          163..208
                     /region_name="LRRCT_2"
                     /note="Leucine rich repeat C-terminal motif; pfam16920"
                     /db_xref="CDD:465313"
     Region          214..299
                     /region_name="ig"
                     /note="Immunoglobulin domain; pfam00047"
                     /db_xref="CDD:395002"
     Region          227..231
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409568"
     Region          240..244
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409568"
     Region          266..270
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409568"
     Region          281..286
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409568"
     Region          294..297
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409568"
     Region          304..396
                     /region_name="IgI_TrKABC_d5"
                     /note="Fifth domain (immunoglobulin-like) of Trk receptors
                     TrkA, TrkB, and TrkC; member of the I-set of Ig
                     superfamily (IgSF) domains; cd04971"
                     /db_xref="CDD:409360"
     Region          305..311
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409360"
     Region          313..316
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409360"
     Region          319..327
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409360"
     Site            328
                     /site_type="other"
                     /note="interdomain interface [polypeptide binding]"
                     /db_xref="CDD:409360"
     Region          330..337
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409360"
     Region          340..343
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409360"
     Region          348..354
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409360"
     Site            order(353,366..367,370)
                     /site_type="other"
                     /note="receptor binding site [polypeptide binding]"
                     /db_xref="CDD:409360"
     Region          358..366
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409360"
     Region          374..382
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409360"
     Region          385..393
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409360"
     CDS             1..503
                     /gene="NTRK3"
                     /gene_synonym="gp145(trkC); GP145-TrkC; TRKC"
                     /coded_by="XM_006720549.5:27..1538"
                     /db_xref="GeneID:4916"
                     /db_xref="HGNC:HGNC:8033"
                     /db_xref="MIM:191316"
ORIGIN      
        1 mdvslcpakc sfwrifllgs vwldyvgsvl acpancvcsk teincrrpdd gnlfpllegq
       61 dsgnsngnas initdisrni tsihienwrs lhtlnavdme lytglqklti knsglrsiqp
      121 rafaknphlr yinlssnrlt tlswqlfqtl slrelqleqn ffncscdirw mqlwqeqgea
      181 klnsqnlyci nadgsqlplf rmnisqcdlp eisvshvnlt vregdnavit cngsgsplpd
      241 vdwivtglqs inthqtnlnw tnvhainltl vnvtsedngf tltciaenvv gmsnasvalt
      301 vyypprvvsl eepelrlehc iefvvrgnpp ptlhwlhngq plreskiihv eyyqegeise
      361 gcllfnkpth ynngnytlia knplgtanqt inghflkepf pestdnfilf devsptppit
      421 vthkpeedtf gvsiavglaa facvllvvlf vminkygrrs kfgmkdglel lavllkcdsk
      481 qlknkegnkm knnngkkkra tsa
//
LOCUS       XP_006720613             495 aa            linear   PRI 05-AUG-2025
DEFINITION  NT-3 growth factor receptor isoform X12 [Homo sapiens].
ACCESSION   XP_006720613
VERSION     XP_006720613.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720550.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..495
                     /product="NT-3 growth factor receptor isoform X12"
                     /calculated_mol_wt=55143
     Region          31..>51
                     /region_name="LRRNT"
                     /note="Leucine rich repeat N-terminal domain; pfam01462"
                     /db_xref="CDD:396168"
     Region          103..160
                     /region_name="LRR_8"
                     /note="Leucine rich repeat; pfam13855"
                     /db_xref="CDD:404697"
     Region          105..128
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          129..151
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          152..164
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          163..208
                     /region_name="LRRCT_2"
                     /note="Leucine rich repeat C-terminal motif; pfam16920"
                     /db_xref="CDD:465313"
     Region          214..299
                     /region_name="ig"
                     /note="Immunoglobulin domain; pfam00047"
                     /db_xref="CDD:395002"
     Region          227..231
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409568"
     Region          240..244
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409568"
     Region          266..270
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409568"
     Region          281..286
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409568"
     Region          294..297
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409568"
     Region          304..396
                     /region_name="IgI_TrKABC_d5"
                     /note="Fifth domain (immunoglobulin-like) of Trk receptors
                     TrkA, TrkB, and TrkC; member of the I-set of Ig
                     superfamily (IgSF) domains; cd04971"
                     /db_xref="CDD:409360"
     Region          305..311
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409360"
     Region          313..316
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409360"
     Region          319..327
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409360"
     Site            328
                     /site_type="other"
                     /note="interdomain interface [polypeptide binding]"
                     /db_xref="CDD:409360"
     Region          330..337
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409360"
     Region          340..343
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409360"
     Region          348..354
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409360"
     Site            order(353,366..367,370)
                     /site_type="other"
                     /note="receptor binding site [polypeptide binding]"
                     /db_xref="CDD:409360"
     Region          358..366
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409360"
     Region          374..382
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409360"
     Region          385..393
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409360"
     CDS             1..495
                     /gene="NTRK3"
                     /gene_synonym="gp145(trkC); GP145-TrkC; TRKC"
                     /coded_by="XM_006720550.5:27..1514"
                     /db_xref="GeneID:4916"
                     /db_xref="HGNC:HGNC:8033"
                     /db_xref="MIM:191316"
ORIGIN      
        1 mdvslcpakc sfwrifllgs vwldyvgsvl acpancvcsk teincrrpdd gnlfpllegq
       61 dsgnsngnas initdisrni tsihienwrs lhtlnavdme lytglqklti knsglrsiqp
      121 rafaknphlr yinlssnrlt tlswqlfqtl slrelqleqn ffncscdirw mqlwqeqgea
      181 klnsqnlyci nadgsqlplf rmnisqcdlp eisvshvnlt vregdnavit cngsgsplpd
      241 vdwivtglqs inthqtnlnw tnvhainltl vnvtsedngf tltciaenvv gmsnasvalt
      301 vyypprvvsl eepelrlehc iefvvrgnpp ptlhwlhngq plreskiihv eyyqegeise
      361 gcllfnkpth ynngnytlia knplgtanqt inghflkepf pvdevsptpp itvthkpeed
      421 tfgvsiavgl aafacvllvv lfvminkygr rskfgmkdgl ellavllkcd skqlknkegn
      481 kmknnngkkk ratsa
//
LOCUS       XP_016877739             482 aa            linear   PRI 05-AUG-2025
DEFINITION  NT-3 growth factor receptor isoform X13 [Homo sapiens].
ACCESSION   XP_016877739
VERSION     XP_016877739.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022250.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..482
                     /product="NT-3 growth factor receptor isoform X13"
                     /calculated_mol_wt=53775
     Region          31..>51
                     /region_name="LRRNT"
                     /note="Leucine rich repeat N-terminal domain; pfam01462"
                     /db_xref="CDD:396168"
     Region          103..160
                     /region_name="LRR_8"
                     /note="Leucine rich repeat; pfam13855"
                     /db_xref="CDD:404697"
     Region          105..128
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          129..151
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          152..164
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          163..208
                     /region_name="LRRCT_2"
                     /note="Leucine rich repeat C-terminal motif; pfam16920"
                     /db_xref="CDD:465313"
     Region          214..299
                     /region_name="ig"
                     /note="Immunoglobulin domain; pfam00047"
                     /db_xref="CDD:395002"
     Region          227..231
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409568"
     Region          240..244
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409568"
     Region          266..270
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409568"
     Region          281..286
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409568"
     Region          294..297
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409568"
     Region          304..396
                     /region_name="IgI_TrKABC_d5"
                     /note="Fifth domain (immunoglobulin-like) of Trk receptors
                     TrkA, TrkB, and TrkC; member of the I-set of Ig
                     superfamily (IgSF) domains; cd04971"
                     /db_xref="CDD:409360"
     Region          305..311
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409360"
     Region          313..316
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409360"
     Region          319..327
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409360"
     Site            328
                     /site_type="other"
                     /note="interdomain interface [polypeptide binding]"
                     /db_xref="CDD:409360"
     Region          330..337
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409360"
     Region          340..343
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409360"
     Region          348..354
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409360"
     Site            order(353,366..367,370)
                     /site_type="other"
                     /note="receptor binding site [polypeptide binding]"
                     /db_xref="CDD:409360"
     Region          358..366
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409360"
     Region          374..382
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409360"
     Region          385..393
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409360"
     CDS             1..482
                     /gene="NTRK3"
                     /gene_synonym="gp145(trkC); GP145-TrkC; TRKC"
                     /coded_by="XM_017022250.3:27..1475"
                     /db_xref="GeneID:4916"
                     /db_xref="HGNC:HGNC:8033"
                     /db_xref="MIM:191316"
ORIGIN      
        1 mdvslcpakc sfwrifllgs vwldyvgsvl acpancvcsk teincrrpdd gnlfpllegq
       61 dsgnsngnas initdisrni tsihienwrs lhtlnavdme lytglqklti knsglrsiqp
      121 rafaknphlr yinlssnrlt tlswqlfqtl slrelqleqn ffncscdirw mqlwqeqgea
      181 klnsqnlyci nadgsqlplf rmnisqcdlp eisvshvnlt vregdnavit cngsgsplpd
      241 vdwivtglqs inthqtnlnw tnvhainltl vnvtsedngf tltciaenvv gmsnasvalt
      301 vyypprvvsl eepelrlehc iefvvrgnpp ptlhwlhngq plreskiihv eyyqegeise
      361 gcllfnkpth ynngnytlia knplgtanqt inghflkepf pestdnfilf devsptppit
      421 vthkpeedtf gvsiavglaa facvllvvlf vminkygrrs kfgmkagpcf pfpfqsqscs
      481 tf
//
LOCUS       XP_011519940             469 aa            linear   PRI 05-AUG-2025
DEFINITION  NT-3 growth factor receptor isoform X14 [Homo sapiens].
ACCESSION   XP_011519940
VERSION     XP_011519940.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521638.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..469
                     /product="NT-3 growth factor receptor isoform X14"
                     /calculated_mol_wt=52329
     Region          31..>51
                     /region_name="LRRNT"
                     /note="Leucine rich repeat N-terminal domain; pfam01462"
                     /db_xref="CDD:396168"
     Region          103..160
                     /region_name="LRR_8"
                     /note="Leucine rich repeat; pfam13855"
                     /db_xref="CDD:404697"
     Region          105..128
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          129..151
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          152..164
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          163..208
                     /region_name="LRRCT_2"
                     /note="Leucine rich repeat C-terminal motif; pfam16920"
                     /db_xref="CDD:465313"
     Region          214..299
                     /region_name="ig"
                     /note="Immunoglobulin domain; pfam00047"
                     /db_xref="CDD:395002"
     Region          227..231
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          240..244
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          266..270
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          281..286
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          294..297
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          304..396
                     /region_name="IgI_TrKABC_d5"
                     /note="Fifth domain (immunoglobulin-like) of Trk receptors
                     TrkA, TrkB, and TrkC; member of the I-set of Ig
                     superfamily (IgSF) domains; cd04971"
                     /db_xref="CDD:409360"
     Region          305..311
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409360"
     Region          313..316
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409360"
     Region          319..327
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409360"
     Site            328
                     /site_type="other"
                     /note="interdomain interface [polypeptide binding]"
                     /db_xref="CDD:409360"
     Region          330..337
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409360"
     Region          340..343
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409360"
     Region          348..354
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409360"
     Site            order(353,366..367,370)
                     /site_type="other"
                     /note="receptor binding site [polypeptide binding]"
                     /db_xref="CDD:409360"
     Region          358..366
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409360"
     Region          374..382
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409360"
     Region          385..393
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409360"
     CDS             1..469
                     /gene="NTRK3"
                     /gene_synonym="gp145(trkC); GP145-TrkC; TRKC"
                     /coded_by="XM_011521638.4:27..1436"
                     /db_xref="GeneID:4916"
                     /db_xref="HGNC:HGNC:8033"
                     /db_xref="MIM:191316"
ORIGIN      
        1 mdvslcpakc sfwrifllgs vwldyvgsvl acpancvcsk teincrrpdd gnlfpllegq
       61 dsgnsngnas initdisrni tsihienwrs lhtlnavdme lytglqklti knsglrsiqp
      121 rafaknphlr yinlssnrlt tlswqlfqtl slrelqleqn ffncscdirw mqlwqeqgea
      181 klnsqnlyci nadgsqlplf rmnisqcdlp eisvshvnlt vregdnavit cngsgsplpd
      241 vdwivtglqs inthqtnlnw tnvhainltl vnvtsedngf tltciaenvv gmsnasvalt
      301 vyypprvvsl eepelrlehc iefvvrgnpp ptlhwlhngq plreskiihv eyyqegeise
      361 gcllfnkpth ynngnytlia knplgtanqt inghflkepf pestdnfilf devsptppit
      421 vthkpeedtf gvsiavglaa facvllvvlf vminkygrrs kfgmkgels
//
LOCUS       XP_047288560             461 aa            linear   PRI 05-AUG-2025
DEFINITION  NT-3 growth factor receptor isoform X15 [Homo sapiens].
ACCESSION   XP_047288560
VERSION     XP_047288560.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432604.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..461
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..461
                     /product="NT-3 growth factor receptor isoform X15"
                     /calculated_mol_wt=51361
     Region          31..>51
                     /region_name="LRRNT"
                     /note="Leucine rich repeat N-terminal domain; pfam01462"
                     /db_xref="CDD:396168"
     Region          103..160
                     /region_name="LRR_8"
                     /note="Leucine rich repeat; pfam13855"
                     /db_xref="CDD:404697"
     Region          105..128
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          129..151
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          152..164
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          163..208
                     /region_name="LRRCT_2"
                     /note="Leucine rich repeat C-terminal motif; pfam16920"
                     /db_xref="CDD:465313"
     Region          214..299
                     /region_name="ig"
                     /note="Immunoglobulin domain; pfam00047"
                     /db_xref="CDD:395002"
     Region          227..231
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          240..244
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          266..270
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          281..286
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          294..297
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          304..396
                     /region_name="IgI_TrKABC_d5"
                     /note="Fifth domain (immunoglobulin-like) of Trk receptors
                     TrkA, TrkB, and TrkC; member of the I-set of Ig
                     superfamily (IgSF) domains; cd04971"
                     /db_xref="CDD:409360"
     Region          305..311
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409360"
     Region          313..316
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409360"
     Region          319..327
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409360"
     Site            328
                     /site_type="other"
                     /note="interdomain interface [polypeptide binding]"
                     /db_xref="CDD:409360"
     Region          330..337
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409360"
     Region          340..343
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409360"
     Region          348..354
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409360"
     Site            order(353,366..367,370)
                     /site_type="other"
                     /note="receptor binding site [polypeptide binding]"
                     /db_xref="CDD:409360"
     Region          358..366
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409360"
     Region          374..382
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409360"
     Region          385..393
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409360"
     CDS             1..461
                     /gene="NTRK3"
                     /gene_synonym="gp145(trkC); GP145-TrkC; TRKC"
                     /coded_by="XM_047432604.1:27..1412"
                     /db_xref="GeneID:4916"
                     /db_xref="HGNC:HGNC:8033"
                     /db_xref="MIM:191316"
ORIGIN      
        1 mdvslcpakc sfwrifllgs vwldyvgsvl acpancvcsk teincrrpdd gnlfpllegq
       61 dsgnsngnas initdisrni tsihienwrs lhtlnavdme lytglqklti knsglrsiqp
      121 rafaknphlr yinlssnrlt tlswqlfqtl slrelqleqn ffncscdirw mqlwqeqgea
      181 klnsqnlyci nadgsqlplf rmnisqcdlp eisvshvnlt vregdnavit cngsgsplpd
      241 vdwivtglqs inthqtnlnw tnvhainltl vnvtsedngf tltciaenvv gmsnasvalt
      301 vyypprvvsl eepelrlehc iefvvrgnpp ptlhwlhngq plreskiihv eyyqegeise
      361 gcllfnkpth ynngnytlia knplgtanqt inghflkepf pvdevsptpp itvthkpeed
      421 tfgvsiavgl aafacvllvv lfvminkygr rskfgmkgel s
//
LOCUS       XP_016877740             456 aa            linear   PRI 05-AUG-2025
DEFINITION  NT-3 growth factor receptor isoform X16 [Homo sapiens].
ACCESSION   XP_016877740
VERSION     XP_016877740.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022251.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..456
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..456
                     /product="NT-3 growth factor receptor isoform X16"
                     /calculated_mol_wt=51211
     Region          163..449
                     /region_name="PTKc_TrkC"
                     /note="Catalytic domain of the Protein Tyrosine Kinase,
                     Tropomyosin Related Kinase C; cd05094"
                     /db_xref="CDD:270676"
     Site            order(175..179,183,201,203,248..251,254..255,310,314..315,
                     317,328,346..350,359,393)
                     /site_type="active"
                     /db_xref="CDD:270676"
     Site            order(175..176,178..179,183,201,203,248..251,254..255,
                     314..315,317,328)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270676"
     Site            order(310,314,346..350,359,393)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270676"
     Site            327..352
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270676"
     CDS             1..456
                     /gene="NTRK3"
                     /gene_synonym="gp145(trkC); GP145-TrkC; TRKC"
                     /coded_by="XM_017022251.3:597..1967"
                     /db_xref="GeneID:4916"
                     /db_xref="HGNC:HGNC:8033"
                     /db_xref="MIM:191316"
ORIGIN      
        1 mcipfmaqpq fmsrlflgvl dkrssqpaga vrestdnfil fdevsptppi tvthkpeedt
       61 fgvsiavgla afacvllvvl fvminkygrr skfgmkgpva visgeedsas plhhinhgit
      121 tpssldagpd tvvigmtrip vienpqyfrq ghnchkpdty vqhikrrdiv lkrelgegaf
      181 gkvflaecyn lsptkdkmlv avkalkdptl aarkdfqrea elltnlqheh ivkfygvcgd
      241 gdplimvfey mkhgdlnkfl rahgpdamil vdgqprqakg elglsqmlhi asqiasgmvy
      301 lasqhfvhrd latrnclvga nllvkigdfg msrdvystdy yrvgghtmlp irwmppesim
      361 yrkfttesdv wsfgvilwei ftygkqpwfq lsntevieci tqgrvlerpr vcpkevydvm
      421 lgcwqrepqq rlnikeiyki lhalgkatpi yldilg
//
LOCUS       XP_016877741             448 aa            linear   PRI 05-AUG-2025
DEFINITION  NT-3 growth factor receptor isoform X17 [Homo sapiens].
ACCESSION   XP_016877741
VERSION     XP_016877741.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022252.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..448
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..448
                     /product="NT-3 growth factor receptor isoform X17"
                     /calculated_mol_wt=50243
     Region          155..441
                     /region_name="PTKc_TrkC"
                     /note="Catalytic domain of the Protein Tyrosine Kinase,
                     Tropomyosin Related Kinase C; cd05094"
                     /db_xref="CDD:270676"
     Site            order(167..171,175,193,195,240..243,246..247,302,306..307,
                     309,320,338..342,351,385)
                     /site_type="active"
                     /db_xref="CDD:270676"
     Site            order(167..168,170..171,175,193,195,240..243,246..247,
                     306..307,309,320)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270676"
     Site            order(302,306,338..342,351,385)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270676"
     Site            319..344
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270676"
     CDS             1..448
                     /gene="NTRK3"
                     /gene_synonym="gp145(trkC); GP145-TrkC; TRKC"
                     /coded_by="XM_017022252.3:597..1943"
                     /db_xref="GeneID:4916"
                     /db_xref="HGNC:HGNC:8033"
                     /db_xref="MIM:191316"
ORIGIN      
        1 mcipfmaqpq fmsrlflgvl dkrssqpaga vrvdevsptp pitvthkpee dtfgvsiavg
       61 laafacvllv vlfvminkyg rrskfgmkgp vavisgeeds asplhhinhg ittpssldag
      121 pdtvvigmtr ipvienpqyf rqghnchkpd tyvqhikrrd ivlkrelgeg afgkvflaec
      181 ynlsptkdkm lvavkalkdp tlaarkdfqr eaelltnlqh ehivkfygvc gdgdplimvf
      241 eymkhgdlnk flrahgpdam ilvdgqprqa kgelglsqml hiasqiasgm vylasqhfvh
      301 rdlatrnclv ganllvkigd fgmsrdvyst dyyrvgghtm lpirwmppes imyrkfttes
      361 dvwsfgvilw eiftygkqpw fqlsntevie citqgrvler prvcpkevyd vmlgcwqrep
      421 qqrlnikeiy kilhalgkat piyldilg
//
LOCUS       XP_016877743             850 aa            linear   PRI 05-AUG-2025
DEFINITION  NT-3 growth factor receptor isoform X18 [Homo sapiens].
ACCESSION   XP_016877743
VERSION     XP_016877743.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022254.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..850
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..850
                     /product="NT-3 growth factor receptor isoform X18"
                     /calculated_mol_wt=95342
     Region          103..160
                     /region_name="LRR_8"
                     /note="Leucine rich repeat; pfam13855"
                     /db_xref="CDD:404697"
     Region          105..128
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          129..151
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          152..164
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          163..208
                     /region_name="LRRCT_2"
                     /note="Leucine rich repeat C-terminal motif; pfam16920"
                     /db_xref="CDD:465313"
     Region          214..299
                     /region_name="ig"
                     /note="Immunoglobulin domain; pfam00047"
                     /db_xref="CDD:395002"
     Region          227..231
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409568"
     Region          240..244
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409568"
     Region          266..270
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409568"
     Region          281..286
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409568"
     Region          294..297
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409568"
     Region          304..396
                     /region_name="IgI_TrKABC_d5"
                     /note="Fifth domain (immunoglobulin-like) of Trk receptors
                     TrkA, TrkB, and TrkC; member of the I-set of Ig
                     superfamily (IgSF) domains; cd04971"
                     /db_xref="CDD:409360"
     Region          305..311
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409360"
     Region          313..316
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409360"
     Region          319..327
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409360"
     Site            328
                     /site_type="other"
                     /note="interdomain interface [polypeptide binding]"
                     /db_xref="CDD:409360"
     Region          330..337
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409360"
     Region          340..343
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409360"
     Region          348..354
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409360"
     Site            order(353,366..367,370)
                     /site_type="other"
                     /note="receptor binding site [polypeptide binding]"
                     /db_xref="CDD:409360"
     Region          358..366
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409360"
     Region          374..382
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409360"
     Region          385..393
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409360"
     Region          532..843
                     /region_name="PTKc_TrkC"
                     /note="Catalytic domain of the Protein Tyrosine Kinase,
                     Tropomyosin Related Kinase C; cd05094"
                     /db_xref="CDD:270676"
     Site            order(544..548,552,570,572,617..620,623..624,679,683..684,
                     686,697,740..744,753,787)
                     /site_type="active"
                     /db_xref="CDD:270676"
     Site            order(544..545,547..548,552,570,572,617..620,623..624,
                     683..684,686,697)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270676"
     Site            order(679,683,740..744,753,787)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270676"
     Site            order(696..711,737..746)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270676"
     CDS             1..850
                     /gene="NTRK3"
                     /gene_synonym="gp145(trkC); GP145-TrkC; TRKC"
                     /coded_by="XM_017022254.3:27..2579"
                     /db_xref="GeneID:4916"
                     /db_xref="HGNC:HGNC:8033"
                     /db_xref="MIM:191316"
ORIGIN      
        1 mdvslcpakc sfwrifllgs vwldyvgsvl acpancvcsk teincrrpdd gnlfpllegq
       61 dsgnsngnas initdisrni tsihienwrs lhtlnavdme lytglqklti knsglrsiqp
      121 rafaknphlr yinlssnrlt tlswqlfqtl slrelqleqn ffncscdirw mqlwqeqgea
      181 klnsqnlyci nadgsqlplf rmnisqcdlp eisvshvnlt vregdnavit cngsgsplpd
      241 vdwivtglqs inthqtnlnw tnvhainltl vnvtsedngf tltciaenvv gmsnasvalt
      301 vyypprvvsl eepelrlehc iefvvrgnpp ptlhwlhngq plreskiihv eyyqegeise
      361 gcllfnkpth ynngnytlia knplgtanqt inghflkepf pestdnfilf devsptppit
      421 vthkpeedtf gvsiavglaa facvllvvlf vminkygrrs kfgmkgpvav isgeedsasp
      481 lhhinhgitt pssldagpdt vvigmtripv ienpqyfrqg hnchkpdtyv qhikrrdivl
      541 krelgegafg kvflaecynl sptkdkmlva vkalkdptla arkdfqreae lltnlqhehi
      601 vkfygvcgdg dplimvfeym khgdlnkflr ahgpdamilv dgqprqakge lglsqmlhia
      661 sqiasgmvyl asqhfvhrdl atrnclvgan llvkigdfgm srdvystdyy regpcqkgpf
      721 svvwqrqrla ataastvggh tmlpirwmpp esimyrkftt esdvwsfgvi lweiftygkq
      781 pwfqlsntev iecitqgrvl erprvcpkev ydvmlgcwqr epqqrlnike iykilhalgk
      841 atpiyldilg
//
LOCUS       XP_016877744             860 aa            linear   PRI 05-AUG-2025
DEFINITION  P protein isoform X1 [Homo sapiens].
ACCESSION   XP_016877744
VERSION     XP_016877744.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022255.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..860
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..860
                     /product="P protein isoform X1"
                     /calculated_mol_wt=95519
     Region          346..851
                     /region_name="P_permease"
                     /note="Permease P (pink-eyed dilution). Mutations in the
                     human melanosomal P gene were responsible for classic
                     phenotype of oculocutaneous albinism type 2 (OCA2).
                     Although the precise function of the P protein is unknown,
                     it was predicted to regulate the...; cd01116"
                     /db_xref="CDD:238536"
     Site            order(350..353,360..373,393..410,433..449,451..468,
                     473..496,523..537,631..643,659..673,685..703,732..747,
                     791..810,836..848)
                     /site_type="other"
                     /note="transmembrane helices"
                     /db_xref="CDD:238536"
     CDS             1..860
                     /gene="OCA2"
                     /gene_synonym="BEY; BEY1; BEY2; BOCA; D15S12; EYCL; EYCL2;
                     EYCL3; HCL3; P; PED; SHEP1; SLC13B1"
                     /coded_by="XM_017022255.2:1343..3925"
                     /db_xref="GeneID:4948"
                     /db_xref="HGNC:HGNC:8101"
                     /db_xref="MIM:611409"
ORIGIN      
        1 mredwqwsmh legrdgrryp gapavellqt svpsglaelv agkrrlprga ggadpshscp
       61 rgaagqsswa pagqefasfl tkgrshsslp qmsssrskds cftentpllr nslqekgsrc
      121 ipvyhpefit aeeswedssa dwerryllsr evsglsasas sekgdlldsp hirlrlsklr
      181 rcvqwlkvmg lfafvvlcsi lfslypdqgk lwqllalspl enysvnlssh vdstllqvdl
      241 agalvasgps rpgreehivv eltqadalgs rwrrpqqvth nwtvylnprr sehsvmsrtf
      301 evltretvsi siraslqqtq avpllmahqy lrgsvetqvt iatailagvy aliifeivhr
      361 tlaamlgsla alaalavigd rpslthvvew idfetlallf gmmilvaifs etgffdycav
      421 kayrlsrgrv wamiimlcli aavlsafldn vttmllftpv tirlcevlnl dprqvliaev
      481 iftniggaat aigdppnvii vsnqelrkmg ldfagftahm figiclvllv cfpllrllyw
      541 nrklynkeps eivelkheih vwrltaqris pasreetavr rlllgkvlal ehllarrlht
      601 fhrqisqedk nwetniqelq kkhrisdgil lakcltvlgf vifmfflnsf vpgihldlgw
      661 iailgaiwll iladihdfei ilhrvewatl lffaalfvlm ealahlhlie yvgeqtalli
      721 kmvpeeqrli aaivlvvwvs alasslidni pftatmidts ylrihqlvlk ipvllnlshd
      781 pevglpappl myalafgacl ggngtligas anvvcagiae qhgygfsfme ffrlgfpmmv
      841 vsctvgmcyl lvahvvvgwn
//
LOCUS       XP_011519942             852 aa            linear   PRI 05-AUG-2025
DEFINITION  P protein isoform X2 [Homo sapiens].
ACCESSION   XP_011519942
VERSION     XP_011519942.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521640.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..852
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..852
                     /product="P protein isoform X2"
                     /calculated_mol_wt=94400
     Region          338..843
                     /region_name="P_permease"
                     /note="Permease P (pink-eyed dilution). Mutations in the
                     human melanosomal P gene were responsible for classic
                     phenotype of oculocutaneous albinism type 2 (OCA2).
                     Although the precise function of the P protein is unknown,
                     it was predicted to regulate the...; cd01116"
                     /db_xref="CDD:238536"
     Site            order(342..345,352..365,385..402,425..441,443..460,
                     465..488,515..529,623..635,651..665,677..695,724..739,
                     783..802,828..840)
                     /site_type="other"
                     /note="transmembrane helices"
                     /db_xref="CDD:238536"
     CDS             1..852
                     /gene="OCA2"
                     /gene_synonym="BEY; BEY1; BEY2; BOCA; D15S12; EYCL; EYCL2;
                     EYCL3; HCL3; P; PED; SHEP1; SLC13B1"
                     /coded_by="XM_011521640.3:114..2672"
                     /db_xref="GeneID:4948"
                     /db_xref="HGNC:HGNC:8101"
                     /db_xref="MIM:611409"
ORIGIN      
        1 mhlegrdgrr ypgapavell qtsvpsglae lvagkrrlpr gaggadpshs cprgaagqss
       61 wapagqefas fltkgrshss lpqmsssrsk dscftentpl lrnslqekgs rcipvyhpef
      121 itaeesweds sadwerryll srevsglsas assekgdlld sphirlrlsk lrrcvqwlkv
      181 mglfafvvlc silfslypdq gklwqllals plenysvnls shvdstllqv dlagalvasg
      241 psrpgreehi vveltqadal gsrwrrpqqv thnwtvylnp rrsehsvmsr tfevltretv
      301 sisiraslqq tqavpllmah qylrgsvetq vtiatailag vyaliifeiv hrtlaamlgs
      361 laalaalavi gdrpslthvv ewidfetlal lfgmmilvai fsetgffdyc avkayrlsrg
      421 rvwamiimlc liaavlsafl dnvttmllft pvtirlcevl nldprqvlia eviftnigga
      481 ataigdppnv iivsnqelrk mgldfagfta hmfigiclvl lvcfpllrll ywnrklynke
      541 pseivelkhe ihvwrltaqr ispasreeta vrrlllgkvl alehllarrl htfhrqisqe
      601 dknwetniqe lqkkhrisdg illakcltvl gfvifmffln sfvpgihldl gwiailgaiw
      661 lliladihdf eiilhrvewa tllffaalfv lmealahlhl ieyvgeqtal likmvpeeqr
      721 liaaivlvvw vsalasslid nipftatmid tsylrihqlv lkipvllnls hdpevglpap
      781 plmyalafga clggngtlig asanvvcagi aeqhgygfsf meffrlgfpm mvvsctvgmc
      841 yllvahvvvg wn
//
LOCUS       XP_016877745             846 aa            linear   PRI 05-AUG-2025
DEFINITION  P protein isoform X3 [Homo sapiens].
ACCESSION   XP_016877745
VERSION     XP_016877745.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022256.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..846
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..846
                     /product="P protein isoform X3"
                     /calculated_mol_wt=93838
     Region          346..837
                     /region_name="P_permease"
                     /note="Permease P (pink-eyed dilution). Mutations in the
                     human melanosomal P gene were responsible for classic
                     phenotype of oculocutaneous albinism type 2 (OCA2).
                     Although the precise function of the P protein is unknown,
                     it was predicted to regulate the...; cd01116"
                     /db_xref="CDD:238536"
     Site            order(350..353,360..373,393..410,433..449,451..468,
                     473..496,523..537,631..643,659..673,685..703,732..747,
                     777..796,822..834)
                     /site_type="other"
                     /note="transmembrane helices"
                     /db_xref="CDD:238536"
     CDS             1..846
                     /gene="OCA2"
                     /gene_synonym="BEY; BEY1; BEY2; BOCA; D15S12; EYCL; EYCL2;
                     EYCL3; HCL3; P; PED; SHEP1; SLC13B1"
                     /coded_by="XM_017022256.2:2295..4835"
                     /db_xref="GeneID:4948"
                     /db_xref="HGNC:HGNC:8101"
                     /db_xref="MIM:611409"
ORIGIN      
        1 mredwqwsmh legrdgrryp gapavellqt svpsglaelv agkrrlprga ggadpshscp
       61 rgaagqsswa pagqefasfl tkgrshsslp qmsssrskds cftentpllr nslqekgsrc
      121 ipvyhpefit aeeswedssa dwerryllsr evsglsasas sekgdlldsp hirlrlsklr
      181 rcvqwlkvmg lfafvvlcsi lfslypdqgk lwqllalspl enysvnlssh vdstllqvdl
      241 agalvasgps rpgreehivv eltqadalgs rwrrpqqvth nwtvylnprr sehsvmsrtf
      301 evltretvsi siraslqqtq avpllmahqy lrgsvetqvt iatailagvy aliifeivhr
      361 tlaamlgsla alaalavigd rpslthvvew idfetlallf gmmilvaifs etgffdycav
      421 kayrlsrgrv wamiimlcli aavlsafldn vttmllftpv tirlcevlnl dprqvliaev
      481 iftniggaat aigdppnvii vsnqelrkmg ldfagftahm figiclvllv cfpllrllyw
      541 nrklynkeps eivelkheih vwrltaqris pasreetavr rlllgkvlal ehllarrlht
      601 fhrqisqedk nwetniqelq kkhrisdgil lakcltvlgf vifmfflnsf vpgihldlgw
      661 iailgaiwll iladihdfei ilhrvewatl lffaalfvlm ealahlhlie yvgeqtalli
      721 kmvpeeqrli aaivlvvwvs alasslidni pftatmipvl lnlshdpevg lpapplmyal
      781 afgaclggng tligasanvv cagiaeqhgy gfsfmeffrl gfpmmvvsct vgmcyllvah
      841 vvvgwn
//
LOCUS       XP_016877746             836 aa            linear   PRI 05-AUG-2025
DEFINITION  P protein isoform X4 [Homo sapiens].
ACCESSION   XP_016877746
VERSION     XP_016877746.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022257.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..836
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..836
                     /product="P protein isoform X4"
                     /calculated_mol_wt=93189
     Region          346..827
                     /region_name="P_permease"
                     /note="Permease P (pink-eyed dilution). Mutations in the
                     human melanosomal P gene were responsible for classic
                     phenotype of oculocutaneous albinism type 2 (OCA2).
                     Although the precise function of the P protein is unknown,
                     it was predicted to regulate the...; cd01116"
                     /db_xref="CDD:238536"
     Site            order(350..353,369..386,409..425,427..444,449..472,
                     499..513,607..619,635..649,661..679,708..723,767..786,
                     812..824)
                     /site_type="other"
                     /note="transmembrane helices"
                     /db_xref="CDD:238536"
     CDS             1..836
                     /gene="OCA2"
                     /gene_synonym="BEY; BEY1; BEY2; BOCA; D15S12; EYCL; EYCL2;
                     EYCL3; HCL3; P; PED; SHEP1; SLC13B1"
                     /coded_by="XM_017022257.2:2296..4806"
                     /db_xref="GeneID:4948"
                     /db_xref="HGNC:HGNC:8101"
                     /db_xref="MIM:611409"
ORIGIN      
        1 mredwqwsmh legrdgrryp gapavellqt svpsglaelv agkrrlprga ggadpshscp
       61 rgaagqsswa pagqefasfl tkgrshsslp qmsssrskds cftentpllr nslqekgsrc
      121 ipvyhpefit aeeswedssa dwerryllsr evsglsasas sekgdlldsp hirlrlsklr
      181 rcvqwlkvmg lfafvvlcsi lfslypdqgk lwqllalspl enysvnlssh vdstllqvdl
      241 agalvasgps rpgreehivv eltqadalgs rwrrpqqvth nwtvylnprr sehsvmsrtf
      301 evltretvsi siraslqqtq avpllmahqy lrgsvetqvt iatailagvy aliiferpsl
      361 thvvewidfe tlallfgmmi lvaifsetgf fdycavkayr lsrgrvwami imlcliaavl
      421 safldnvttm llftpvtirl cevlnldprq vliaeviftn iggaataigd ppnviivsnq
      481 elrkmgldfa gftahmfigi clvllvcfpl lrllywnrkl ynkepseive lkheihvwrl
      541 taqrispasr eetavrrlll gkvlalehll arrlhtfhrq isqedknwet niqelqkkhr
      601 isdgillakc ltvlgfvifm fflnsfvpgi hldlgwiail gaiwllilad ihdfeiilhr
      661 vewatllffa alfvlmeala hlhlieyvge qtallikmvp eeqrliaaiv lvvwvsalas
      721 slidnipfta tmidtsylri hqlvlkipvl lnlshdpevg lpapplmyal afgaclggng
      781 tligasanvv cagiaeqhgy gfsfmeffrl gfpmmvvsct vgmcyllvah vvvgwn
//
LOCUS       XP_016877747             835 aa            linear   PRI 05-AUG-2025
DEFINITION  P protein isoform X5 [Homo sapiens].
ACCESSION   XP_016877747
VERSION     XP_016877747.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022258.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..835
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..835
                     /product="P protein isoform X5"
                     /calculated_mol_wt=92881
     Region          346..819
                     /region_name="P_permease"
                     /note="Permease P (pink-eyed dilution). Mutations in the
                     human melanosomal P gene were responsible for classic
                     phenotype of oculocutaneous albinism type 2 (OCA2).
                     Although the precise function of the P protein is unknown,
                     it was predicted to regulate the...; cd01116"
                     /db_xref="CDD:238536"
     Site            order(350..353,360..373,393..410,433..449,451..468,
                     473..496,523..537,631..643,659..673,685..703,732..747,
                     777..796)
                     /site_type="other"
                     /note="transmembrane helices"
                     /db_xref="CDD:238536"
     CDS             1..835
                     /gene="OCA2"
                     /gene_synonym="BEY; BEY1; BEY2; BOCA; D15S12; EYCL; EYCL2;
                     EYCL3; HCL3; P; PED; SHEP1; SLC13B1"
                     /coded_by="XM_017022258.2:2298..4805"
                     /db_xref="GeneID:4948"
                     /db_xref="HGNC:HGNC:8101"
                     /db_xref="MIM:611409"
ORIGIN      
        1 mredwqwsmh legrdgrryp gapavellqt svpsglaelv agkrrlprga ggadpshscp
       61 rgaagqsswa pagqefasfl tkgrshsslp qmsssrskds cftentpllr nslqekgsrc
      121 ipvyhpefit aeeswedssa dwerryllsr evsglsasas sekgdlldsp hirlrlsklr
      181 rcvqwlkvmg lfafvvlcsi lfslypdqgk lwqllalspl enysvnlssh vdstllqvdl
      241 agalvasgps rpgreehivv eltqadalgs rwrrpqqvth nwtvylnprr sehsvmsrtf
      301 evltretvsi siraslqqtq avpllmahqy lrgsvetqvt iatailagvy aliifeivhr
      361 tlaamlgsla alaalavigd rpslthvvew idfetlallf gmmilvaifs etgffdycav
      421 kayrlsrgrv wamiimlcli aavlsafldn vttmllftpv tirlcevlnl dprqvliaev
      481 iftniggaat aigdppnvii vsnqelrkmg ldfagftahm figiclvllv cfpllrllyw
      541 nrklynkeps eivelkheih vwrltaqris pasreetavr rlllgkvlal ehllarrlht
      601 fhrqisqedk nwetniqelq kkhrisdgil lakcltvlgf vifmfflnsf vpgihldlgw
      661 iailgaiwll iladihdfei ilhrvewatl lffaalfvlm ealahlhlie yvgeqtalli
      721 kmvpeeqrli aaivlvvwvs alasslidni pftatmipvl lnlshdpevg lpapplmyal
      781 afgaclggng tligasanvv cagiaeqhgy gfsfmeffrk reretrdvla qrkal
//
LOCUS       XP_047288561             828 aa            linear   PRI 05-AUG-2025
DEFINITION  P protein isoform X6 [Homo sapiens].
ACCESSION   XP_047288561
VERSION     XP_047288561.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432605.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..828
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..828
                     /product="P protein isoform X6"
                     /calculated_mol_wt=92070
     Region          338..819
                     /region_name="P_permease"
                     /note="Permease P (pink-eyed dilution). Mutations in the
                     human melanosomal P gene were responsible for classic
                     phenotype of oculocutaneous albinism type 2 (OCA2).
                     Although the precise function of the P protein is unknown,
                     it was predicted to regulate the...; cd01116"
                     /db_xref="CDD:238536"
     Site            order(342..345,361..378,401..417,419..436,441..464,
                     491..505,599..611,627..641,653..671,700..715,759..778,
                     804..816)
                     /site_type="other"
                     /note="transmembrane helices"
                     /db_xref="CDD:238536"
     CDS             1..828
                     /gene="OCA2"
                     /gene_synonym="BEY; BEY1; BEY2; BOCA; D15S12; EYCL; EYCL2;
                     EYCL3; HCL3; P; PED; SHEP1; SLC13B1"
                     /coded_by="XM_047432605.1:114..2600"
                     /db_xref="GeneID:4948"
                     /db_xref="HGNC:HGNC:8101"
                     /db_xref="MIM:611409"
ORIGIN      
        1 mhlegrdgrr ypgapavell qtsvpsglae lvagkrrlpr gaggadpshs cprgaagqss
       61 wapagqefas fltkgrshss lpqmsssrsk dscftentpl lrnslqekgs rcipvyhpef
      121 itaeesweds sadwerryll srevsglsas assekgdlld sphirlrlsk lrrcvqwlkv
      181 mglfafvvlc silfslypdq gklwqllals plenysvnls shvdstllqv dlagalvasg
      241 psrpgreehi vveltqadal gsrwrrpqqv thnwtvylnp rrsehsvmsr tfevltretv
      301 sisiraslqq tqavpllmah qylrgsvetq vtiatailag vyaliiferp slthvvewid
      361 fetlallfgm milvaifset gffdycavka yrlsrgrvwa miimlcliaa vlsafldnvt
      421 tmllftpvti rlcevlnldp rqvliaevif tniggaatai gdppnviivs nqelrkmgld
      481 fagftahmfi giclvllvcf pllrllywnr klynkepsei velkheihvw rltaqrispa
      541 sreetavrrl llgkvlaleh llarrlhtfh rqisqedknw etniqelqkk hrisdgilla
      601 kcltvlgfvi fmfflnsfvp gihldlgwia ilgaiwllil adihdfeiil hrvewatllf
      661 faalfvlmea lahlhlieyv geqtallikm vpeeqrliaa ivlvvwvsal asslidnipf
      721 tatmidtsyl rihqlvlkip vllnlshdpe vglpapplmy alafgaclgg ngtligasan
      781 vvcagiaeqh gygfsfmeff rlgfpmmvvs ctvgmcyllv ahvvvgwn
//
LOCUS       XP_047288562             827 aa            linear   PRI 05-AUG-2025
DEFINITION  P protein isoform X7 [Homo sapiens].
ACCESSION   XP_047288562
VERSION     XP_047288562.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432606.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..827
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..827
                     /product="P protein isoform X7"
                     /calculated_mol_wt=91762
     Region          338..811
                     /region_name="P_permease"
                     /note="Permease P (pink-eyed dilution). Mutations in the
                     human melanosomal P gene were responsible for classic
                     phenotype of oculocutaneous albinism type 2 (OCA2).
                     Although the precise function of the P protein is unknown,
                     it was predicted to regulate the...; cd01116"
                     /db_xref="CDD:238536"
     Site            order(342..345,352..365,385..402,425..441,443..460,
                     465..488,515..529,623..635,651..665,677..695,724..739,
                     769..788)
                     /site_type="other"
                     /note="transmembrane helices"
                     /db_xref="CDD:238536"
     CDS             1..827
                     /gene="OCA2"
                     /gene_synonym="BEY; BEY1; BEY2; BOCA; D15S12; EYCL; EYCL2;
                     EYCL3; HCL3; P; PED; SHEP1; SLC13B1"
                     /coded_by="XM_047432606.1:114..2597"
                     /db_xref="GeneID:4948"
                     /db_xref="HGNC:HGNC:8101"
                     /db_xref="MIM:611409"
ORIGIN      
        1 mhlegrdgrr ypgapavell qtsvpsglae lvagkrrlpr gaggadpshs cprgaagqss
       61 wapagqefas fltkgrshss lpqmsssrsk dscftentpl lrnslqekgs rcipvyhpef
      121 itaeesweds sadwerryll srevsglsas assekgdlld sphirlrlsk lrrcvqwlkv
      181 mglfafvvlc silfslypdq gklwqllals plenysvnls shvdstllqv dlagalvasg
      241 psrpgreehi vveltqadal gsrwrrpqqv thnwtvylnp rrsehsvmsr tfevltretv
      301 sisiraslqq tqavpllmah qylrgsvetq vtiatailag vyaliifeiv hrtlaamlgs
      361 laalaalavi gdrpslthvv ewidfetlal lfgmmilvai fsetgffdyc avkayrlsrg
      421 rvwamiimlc liaavlsafl dnvttmllft pvtirlcevl nldprqvlia eviftnigga
      481 ataigdppnv iivsnqelrk mgldfagfta hmfigiclvl lvcfpllrll ywnrklynke
      541 pseivelkhe ihvwrltaqr ispasreeta vrrlllgkvl alehllarrl htfhrqisqe
      601 dknwetniqe lqkkhrisdg illakcltvl gfvifmffln sfvpgihldl gwiailgaiw
      661 lliladihdf eiilhrvewa tllffaalfv lmealahlhl ieyvgeqtal likmvpeeqr
      721 liaaivlvvw vsalasslid nipftatmip vllnlshdpe vglpapplmy alafgaclgg
      781 ngtligasan vvcagiaeqh gygfsfmeff rkreretrdv laqrkal
//
LOCUS       XP_016877748             822 aa            linear   PRI 05-AUG-2025
DEFINITION  P protein isoform X8 [Homo sapiens].
ACCESSION   XP_016877748
VERSION     XP_016877748.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022259.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..822
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..822
                     /product="P protein isoform X8"
                     /calculated_mol_wt=91508
     Region          346..813
                     /region_name="P_permease"
                     /note="Permease P (pink-eyed dilution). Mutations in the
                     human melanosomal P gene were responsible for classic
                     phenotype of oculocutaneous albinism type 2 (OCA2).
                     Although the precise function of the P protein is unknown,
                     it was predicted to regulate the...; cd01116"
                     /db_xref="CDD:238536"
     Site            order(350..353,369..386,409..425,427..444,449..472,
                     499..513,607..619,635..649,661..679,708..723,753..772,
                     798..810)
                     /site_type="other"
                     /note="transmembrane helices"
                     /db_xref="CDD:238536"
     CDS             1..822
                     /gene="OCA2"
                     /gene_synonym="BEY; BEY1; BEY2; BOCA; D15S12; EYCL; EYCL2;
                     EYCL3; HCL3; P; PED; SHEP1; SLC13B1"
                     /coded_by="XM_017022259.2:2294..4762"
                     /db_xref="GeneID:4948"
                     /db_xref="HGNC:HGNC:8101"
                     /db_xref="MIM:611409"
ORIGIN      
        1 mredwqwsmh legrdgrryp gapavellqt svpsglaelv agkrrlprga ggadpshscp
       61 rgaagqsswa pagqefasfl tkgrshsslp qmsssrskds cftentpllr nslqekgsrc
      121 ipvyhpefit aeeswedssa dwerryllsr evsglsasas sekgdlldsp hirlrlsklr
      181 rcvqwlkvmg lfafvvlcsi lfslypdqgk lwqllalspl enysvnlssh vdstllqvdl
      241 agalvasgps rpgreehivv eltqadalgs rwrrpqqvth nwtvylnprr sehsvmsrtf
      301 evltretvsi siraslqqtq avpllmahqy lrgsvetqvt iatailagvy aliiferpsl
      361 thvvewidfe tlallfgmmi lvaifsetgf fdycavkayr lsrgrvwami imlcliaavl
      421 safldnvttm llftpvtirl cevlnldprq vliaeviftn iggaataigd ppnviivsnq
      481 elrkmgldfa gftahmfigi clvllvcfpl lrllywnrkl ynkepseive lkheihvwrl
      541 taqrispasr eetavrrlll gkvlalehll arrlhtfhrq isqedknwet niqelqkkhr
      601 isdgillakc ltvlgfvifm fflnsfvpgi hldlgwiail gaiwllilad ihdfeiilhr
      661 vewatllffa alfvlmeala hlhlieyvge qtallikmvp eeqrliaaiv lvvwvsalas
      721 slidnipfta tmipvllnls hdpevglpap plmyalafga clggngtlig asanvvcagi
      781 aeqhgygfsf meffrlgfpm mvvsctvgmc yllvahvvvg wn
//
LOCUS       XP_016877749             814 aa            linear   PRI 05-AUG-2025
DEFINITION  P protein isoform X9 [Homo sapiens].
ACCESSION   XP_016877749
VERSION     XP_016877749.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022260.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..814
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..814
                     /product="P protein isoform X9"
                     /calculated_mol_wt=90632
     Region          351..805
                     /region_name="P_permease"
                     /note="Permease P (pink-eyed dilution). Mutations in the
                     human melanosomal P gene were responsible for classic
                     phenotype of oculocutaneous albinism type 2 (OCA2).
                     Although the precise function of the P protein is unknown,
                     it was predicted to regulate the...; cd01116"
                     /db_xref="CDD:238536"
     Site            order(351..364,387..403,405..422,427..450,477..491,
                     585..597,613..627,639..657,686..701,745..764,790..802)
                     /site_type="other"
                     /note="transmembrane helices"
                     /db_xref="CDD:238536"
     CDS             1..814
                     /gene="OCA2"
                     /gene_synonym="BEY; BEY1; BEY2; BOCA; D15S12; EYCL; EYCL2;
                     EYCL3; HCL3; P; PED; SHEP1; SLC13B1"
                     /coded_by="XM_017022260.2:2297..4741"
                     /db_xref="GeneID:4948"
                     /db_xref="HGNC:HGNC:8101"
                     /db_xref="MIM:611409"
ORIGIN      
        1 mredwqwsmh legrdgrryp gapavellqt svpsglaelv agkrrlprga ggadpshscp
       61 rgaagqsswa pagqefasfl tkgrshsslp qmsssrskds cftentpllr nslqekgsrc
      121 ipvyhpefit aeeswedssa dwerryllsr evsglsasas sekgdlldsp hirlrlsklr
      181 rcvqwlkvmg lfafvvlcsi lfslypdqgk lwqllalspl enysvnlssh vdstllqvdl
      241 agalvasgps rpgreehivv eltqadalgs rwrrpqqvth nwtvylnprr sehsvmsrtf
      301 evltretvsi siraslqqtq avpllmahqy lrgsvetqvt iatailagvy aliifemilv
      361 aifsetgffd ycavkayrls rgrvwamiim lcliaavlsa fldnvttmll ftpvtirlce
      421 vlnldprqvl iaeviftnig gaataigdpp nviivsnqel rkmgldfagf tahmfigicl
      481 vllvcfpllr llywnrklyn kepseivelk heihvwrlta qrispasree tavrrlllgk
      541 vlalehllar rlhtfhrqis qedknwetni qelqkkhris dgillakclt vlgfvifmff
      601 lnsfvpgihl dlgwiailga iwlliladih dfeiilhrve watllffaal fvlmealahl
      661 hlieyvgeqt allikmvpee qrliaaivlv vwvsalassl idnipftatm idtsylrihq
      721 lvlkipvlln lshdpevglp applmyalaf gaclggngtl igasanvvca giaeqhgygf
      781 sfmeffrlgf pmmvvsctvg mcyllvahvv vgwn
//
LOCUS       XP_047288563             811 aa            linear   PRI 05-AUG-2025
DEFINITION  P protein isoform X10 [Homo sapiens].
ACCESSION   XP_047288563
VERSION     XP_047288563.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432607.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..811
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..811
                     /product="P protein isoform X10"
                     /calculated_mol_wt=90551
     Region          346..795
                     /region_name="P_permease"
                     /note="Permease P (pink-eyed dilution). Mutations in the
                     human melanosomal P gene were responsible for classic
                     phenotype of oculocutaneous albinism type 2 (OCA2).
                     Although the precise function of the P protein is unknown,
                     it was predicted to regulate the...; cd01116"
                     /db_xref="CDD:238536"
     Site            order(350..353,369..386,409..425,427..444,449..472,
                     499..513,607..619,635..649,661..679,708..723,753..772)
                     /site_type="other"
                     /note="transmembrane helices"
                     /db_xref="CDD:238536"
     CDS             1..811
                     /gene="OCA2"
                     /gene_synonym="BEY; BEY1; BEY2; BOCA; D15S12; EYCL; EYCL2;
                     EYCL3; HCL3; P; PED; SHEP1; SLC13B1"
                     /coded_by="XM_047432607.1:2297..4732"
                     /db_xref="GeneID:4948"
                     /db_xref="HGNC:HGNC:8101"
                     /db_xref="MIM:611409"
ORIGIN      
        1 mredwqwsmh legrdgrryp gapavellqt svpsglaelv agkrrlprga ggadpshscp
       61 rgaagqsswa pagqefasfl tkgrshsslp qmsssrskds cftentpllr nslqekgsrc
      121 ipvyhpefit aeeswedssa dwerryllsr evsglsasas sekgdlldsp hirlrlsklr
      181 rcvqwlkvmg lfafvvlcsi lfslypdqgk lwqllalspl enysvnlssh vdstllqvdl
      241 agalvasgps rpgreehivv eltqadalgs rwrrpqqvth nwtvylnprr sehsvmsrtf
      301 evltretvsi siraslqqtq avpllmahqy lrgsvetqvt iatailagvy aliiferpsl
      361 thvvewidfe tlallfgmmi lvaifsetgf fdycavkayr lsrgrvwami imlcliaavl
      421 safldnvttm llftpvtirl cevlnldprq vliaeviftn iggaataigd ppnviivsnq
      481 elrkmgldfa gftahmfigi clvllvcfpl lrllywnrkl ynkepseive lkheihvwrl
      541 taqrispasr eetavrrlll gkvlalehll arrlhtfhrq isqedknwet niqelqkkhr
      601 isdgillakc ltvlgfvifm fflnsfvpgi hldlgwiail gaiwllilad ihdfeiilhr
      661 vewatllffa alfvlmeala hlhlieyvge qtallikmvp eeqrliaaiv lvvwvsalas
      721 slidnipfta tmipvllnls hdpevglpap plmyalafga clggngtlig asanvvcagi
      781 aeqhgygfsf meffrkrere trdvlaqrka l
//
LOCUS       XP_047288564             806 aa            linear   PRI 05-AUG-2025
DEFINITION  P protein isoform X11 [Homo sapiens].
ACCESSION   XP_047288564
VERSION     XP_047288564.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432608.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..806
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..806
                     /product="P protein isoform X11"
                     /calculated_mol_wt=89513
     Region          343..797
                     /region_name="P_permease"
                     /note="Permease P (pink-eyed dilution). Mutations in the
                     human melanosomal P gene were responsible for classic
                     phenotype of oculocutaneous albinism type 2 (OCA2).
                     Although the precise function of the P protein is unknown,
                     it was predicted to regulate the...; cd01116"
                     /db_xref="CDD:238536"
     Site            order(343..356,379..395,397..414,419..442,469..483,
                     577..589,605..619,631..649,678..693,737..756,782..794)
                     /site_type="other"
                     /note="transmembrane helices"
                     /db_xref="CDD:238536"
     CDS             1..806
                     /gene="OCA2"
                     /gene_synonym="BEY; BEY1; BEY2; BOCA; D15S12; EYCL; EYCL2;
                     EYCL3; HCL3; P; PED; SHEP1; SLC13B1"
                     /coded_by="XM_047432608.1:114..2534"
                     /db_xref="GeneID:4948"
                     /db_xref="HGNC:HGNC:8101"
                     /db_xref="MIM:611409"
ORIGIN      
        1 mhlegrdgrr ypgapavell qtsvpsglae lvagkrrlpr gaggadpshs cprgaagqss
       61 wapagqefas fltkgrshss lpqmsssrsk dscftentpl lrnslqekgs rcipvyhpef
      121 itaeesweds sadwerryll srevsglsas assekgdlld sphirlrlsk lrrcvqwlkv
      181 mglfafvvlc silfslypdq gklwqllals plenysvnls shvdstllqv dlagalvasg
      241 psrpgreehi vveltqadal gsrwrrpqqv thnwtvylnp rrsehsvmsr tfevltretv
      301 sisiraslqq tqavpllmah qylrgsvetq vtiatailag vyaliifemi lvaifsetgf
      361 fdycavkayr lsrgrvwami imlcliaavl safldnvttm llftpvtirl cevlnldprq
      421 vliaeviftn iggaataigd ppnviivsnq elrkmgldfa gftahmfigi clvllvcfpl
      481 lrllywnrkl ynkepseive lkheihvwrl taqrispasr eetavrrlll gkvlalehll
      541 arrlhtfhrq isqedknwet niqelqkkhr isdgillakc ltvlgfvifm fflnsfvpgi
      601 hldlgwiail gaiwllilad ihdfeiilhr vewatllffa alfvlmeala hlhlieyvge
      661 qtallikmvp eeqrliaaiv lvvwvsalas slidnipfta tmidtsylri hqlvlkipvl
      721 lnlshdpevg lpapplmyal afgaclggng tligasanvv cagiaeqhgy gfsfmeffrl
      781 gfpmmvvsct vgmcyllvah vvvgwn
//
LOCUS       XP_047288565             803 aa            linear   PRI 05-AUG-2025
DEFINITION  P protein isoform X12 [Homo sapiens].
ACCESSION   XP_047288565
VERSION     XP_047288565.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432609.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..803
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..803
                     /product="P protein isoform X12"
                     /calculated_mol_wt=89432
     Region          338..787
                     /region_name="P_permease"
                     /note="Permease P (pink-eyed dilution). Mutations in the
                     human melanosomal P gene were responsible for classic
                     phenotype of oculocutaneous albinism type 2 (OCA2).
                     Although the precise function of the P protein is unknown,
                     it was predicted to regulate the...; cd01116"
                     /db_xref="CDD:238536"
     Site            order(342..345,361..378,401..417,419..436,441..464,
                     491..505,599..611,627..641,653..671,700..715,745..764)
                     /site_type="other"
                     /note="transmembrane helices"
                     /db_xref="CDD:238536"
     CDS             1..803
                     /gene="OCA2"
                     /gene_synonym="BEY; BEY1; BEY2; BOCA; D15S12; EYCL; EYCL2;
                     EYCL3; HCL3; P; PED; SHEP1; SLC13B1"
                     /coded_by="XM_047432609.1:114..2525"
                     /db_xref="GeneID:4948"
                     /db_xref="HGNC:HGNC:8101"
                     /db_xref="MIM:611409"
ORIGIN      
        1 mhlegrdgrr ypgapavell qtsvpsglae lvagkrrlpr gaggadpshs cprgaagqss
       61 wapagqefas fltkgrshss lpqmsssrsk dscftentpl lrnslqekgs rcipvyhpef
      121 itaeesweds sadwerryll srevsglsas assekgdlld sphirlrlsk lrrcvqwlkv
      181 mglfafvvlc silfslypdq gklwqllals plenysvnls shvdstllqv dlagalvasg
      241 psrpgreehi vveltqadal gsrwrrpqqv thnwtvylnp rrsehsvmsr tfevltretv
      301 sisiraslqq tqavpllmah qylrgsvetq vtiatailag vyaliiferp slthvvewid
      361 fetlallfgm milvaifset gffdycavka yrlsrgrvwa miimlcliaa vlsafldnvt
      421 tmllftpvti rlcevlnldp rqvliaevif tniggaatai gdppnviivs nqelrkmgld
      481 fagftahmfi giclvllvcf pllrllywnr klynkepsei velkheihvw rltaqrispa
      541 sreetavrrl llgkvlaleh llarrlhtfh rqisqedknw etniqelqkk hrisdgilla
      601 kcltvlgfvi fmfflnsfvp gihldlgwia ilgaiwllil adihdfeiil hrvewatllf
      661 faalfvlmea lahlhlieyv geqtallikm vpeeqrliaa ivlvvwvsal asslidnipf
      721 tatmipvlln lshdpevglp applmyalaf gaclggngtl igasanvvca giaeqhgygf
      781 sfmeffrkre retrdvlaqr kal
//
LOCUS       XP_047288566             800 aa            linear   PRI 05-AUG-2025
DEFINITION  P protein isoform X13 [Homo sapiens].
ACCESSION   XP_047288566
VERSION     XP_047288566.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432610.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..800
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..800
                     /product="P protein isoform X13"
                     /calculated_mol_wt=88951
     Region          351..791
                     /region_name="P_permease"
                     /note="Permease P (pink-eyed dilution). Mutations in the
                     human melanosomal P gene were responsible for classic
                     phenotype of oculocutaneous albinism type 2 (OCA2).
                     Although the precise function of the P protein is unknown,
                     it was predicted to regulate the...; cd01116"
                     /db_xref="CDD:238536"
     Site            order(351..364,387..403,405..422,427..450,477..491,
                     585..597,613..627,639..657,686..701,731..750,776..788)
                     /site_type="other"
                     /note="transmembrane helices"
                     /db_xref="CDD:238536"
     CDS             1..800
                     /gene="OCA2"
                     /gene_synonym="BEY; BEY1; BEY2; BOCA; D15S12; EYCL; EYCL2;
                     EYCL3; HCL3; P; PED; SHEP1; SLC13B1"
                     /coded_by="XM_047432610.1:2294..4696"
                     /db_xref="GeneID:4948"
                     /db_xref="HGNC:HGNC:8101"
                     /db_xref="MIM:611409"
ORIGIN      
        1 mredwqwsmh legrdgrryp gapavellqt svpsglaelv agkrrlprga ggadpshscp
       61 rgaagqsswa pagqefasfl tkgrshsslp qmsssrskds cftentpllr nslqekgsrc
      121 ipvyhpefit aeeswedssa dwerryllsr evsglsasas sekgdlldsp hirlrlsklr
      181 rcvqwlkvmg lfafvvlcsi lfslypdqgk lwqllalspl enysvnlssh vdstllqvdl
      241 agalvasgps rpgreehivv eltqadalgs rwrrpqqvth nwtvylnprr sehsvmsrtf
      301 evltretvsi siraslqqtq avpllmahqy lrgsvetqvt iatailagvy aliifemilv
      361 aifsetgffd ycavkayrls rgrvwamiim lcliaavlsa fldnvttmll ftpvtirlce
      421 vlnldprqvl iaeviftnig gaataigdpp nviivsnqel rkmgldfagf tahmfigicl
      481 vllvcfpllr llywnrklyn kepseivelk heihvwrlta qrispasree tavrrlllgk
      541 vlalehllar rlhtfhrqis qedknwetni qelqkkhris dgillakclt vlgfvifmff
      601 lnsfvpgihl dlgwiailga iwlliladih dfeiilhrve watllffaal fvlmealahl
      661 hlieyvgeqt allikmvpee qrliaaivlv vwvsalassl idnipftatm ipvllnlshd
      721 pevglpappl myalafgacl ggngtligas anvvcagiae qhgygfsfme ffrlgfpmmv
      781 vsctvgmcyl lvahvvvgwn
//
LOCUS       XP_016877750             795 aa            linear   PRI 05-AUG-2025
DEFINITION  P protein isoform X14 [Homo sapiens].
ACCESSION   XP_016877750
VERSION     XP_016877750.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022261.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..795
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..795
                     /product="P protein isoform X14"
                     /calculated_mol_wt=88739
     Region          281..786
                     /region_name="P_permease"
                     /note="Permease P (pink-eyed dilution). Mutations in the
                     human melanosomal P gene were responsible for classic
                     phenotype of oculocutaneous albinism type 2 (OCA2).
                     Although the precise function of the P protein is unknown,
                     it was predicted to regulate the...; cd01116"
                     /db_xref="CDD:238536"
     Site            order(285..288,295..308,328..345,368..384,386..403,
                     408..431,458..472,566..578,594..608,620..638,667..682,
                     726..745,771..783)
                     /site_type="other"
                     /note="transmembrane helices"
                     /db_xref="CDD:238536"
     CDS             1..795
                     /gene="OCA2"
                     /gene_synonym="BEY; BEY1; BEY2; BOCA; D15S12; EYCL; EYCL2;
                     EYCL3; HCL3; P; PED; SHEP1; SLC13B1"
                     /coded_by="XM_017022261.2:778..3165"
                     /db_xref="GeneID:4948"
                     /db_xref="HGNC:HGNC:8101"
                     /db_xref="MIM:611409"
ORIGIN      
        1 mgrqmrqqdc psqdvsdgrs hsslpqmsss rskdscften tpllrnslqe kgsrcipvyh
       61 pefitaeesw edssadwerr yllsrevsgl sasassekgd lldsphirlr lsklrrcvqw
      121 lkvmglfafv vlcsilfsly pdqgklwqll alsplenysv nlsshvdstl lqvdlagalv
      181 asgpsrpgre ehivveltqa dalgsrwrrp qqvthnwtvy lnprrsehsv msrtfevltr
      241 etvsisiras lqqtqavpll mahqylrgsv etqvtiatai lagvyaliif eivhrtlaam
      301 lgslaalaal avigdrpslt hvvewidfet lallfgmmil vaifsetgff dycavkayrl
      361 srgrvwamii mlcliaavls afldnvttml lftpvtirlc evlnldprqv liaeviftni
      421 ggaataigdp pnviivsnqe lrkmgldfag ftahmfigic lvllvcfpll rllywnrkly
      481 nkepseivel kheihvwrlt aqrispasre etavrrlllg kvlalehlla rrlhtfhrqi
      541 sqedknwetn iqelqkkhri sdgillakcl tvlgfvifmf flnsfvpgih ldlgwiailg
      601 aiwlliladi hdfeiilhrv ewatllffaa lfvlmealah lhlieyvgeq tallikmvpe
      661 eqrliaaivl vvwvsalass lidnipftat midtsylrih qlvlkipvll nlshdpevgl
      721 papplmyala fgaclggngt ligasanvvc agiaeqhgyg fsfmeffrlg fpmmvvsctv
      781 gmcyllvahv vvgwn
//
LOCUS       XP_016877751             793 aa            linear   PRI 05-AUG-2025
DEFINITION  P protein isoform X15 [Homo sapiens].
ACCESSION   XP_016877751
VERSION     XP_016877751.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022262.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..793
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..793
                     /product="P protein isoform X15"
                     /calculated_mol_wt=88259
     Region          346..785
                     /region_name="P_permease"
                     /note="Permease P (pink-eyed dilution). Mutations in the
                     human melanosomal P gene were responsible for classic
                     phenotype of oculocutaneous albinism type 2 (OCA2).
                     Although the precise function of the P protein is unknown,
                     it was predicted to regulate the...; cd01116"
                     /db_xref="CDD:238536"
     Site            order(350..353,360..373,393..410,433..449,451..468,
                     473..496,523..537,631..643,659..673,685..703,732..747,
                     769..785)
                     /site_type="other"
                     /note="transmembrane helices"
                     /db_xref="CDD:238536"
     CDS             1..793
                     /gene="OCA2"
                     /gene_synonym="BEY; BEY1; BEY2; BOCA; D15S12; EYCL; EYCL2;
                     EYCL3; HCL3; P; PED; SHEP1; SLC13B1"
                     /coded_by="XM_017022262.2:2299..4680"
                     /db_xref="GeneID:4948"
                     /db_xref="HGNC:HGNC:8101"
                     /db_xref="MIM:611409"
ORIGIN      
        1 mredwqwsmh legrdgrryp gapavellqt svpsglaelv agkrrlprga ggadpshscp
       61 rgaagqsswa pagqefasfl tkgrshsslp qmsssrskds cftentpllr nslqekgsrc
      121 ipvyhpefit aeeswedssa dwerryllsr evsglsasas sekgdlldsp hirlrlsklr
      181 rcvqwlkvmg lfafvvlcsi lfslypdqgk lwqllalspl enysvnlssh vdstllqvdl
      241 agalvasgps rpgreehivv eltqadalgs rwrrpqqvth nwtvylnprr sehsvmsrtf
      301 evltretvsi siraslqqtq avpllmahqy lrgsvetqvt iatailagvy aliifeivhr
      361 tlaamlgsla alaalavigd rpslthvvew idfetlallf gmmilvaifs etgffdycav
      421 kayrlsrgrv wamiimlcli aavlsafldn vttmllftpv tirlcevlnl dprqvliaev
      481 iftniggaat aigdppnvii vsnqelrkmg ldfagftahm figiclvllv cfpllrllyw
      541 nrklynkeps eivelkheih vwrltaqris pasreetavr rlllgkvlal ehllarrlht
      601 fhrqisqedk nwetniqelq kkhrisdgil lakcltvlgf vifmfflnsf vpgihldlgw
      661 iailgaiwll iladihdfei ilhrvewatl lffaalfvlm ealahlhlie yvgeqtalli
      721 kmvpeeqrli aaivlvvwvs alasslidni pftatmaglp ndgcvlhcwd vlspcgscgg
      781 gmelidihll led
//
LOCUS       XP_047288567             792 aa            linear   PRI 05-AUG-2025
DEFINITION  P protein isoform X16 [Homo sapiens].
ACCESSION   XP_047288567
VERSION     XP_047288567.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432611.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..792
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..792
                     /product="P protein isoform X16"
                     /calculated_mol_wt=87832
     Region          343..783
                     /region_name="P_permease"
                     /note="Permease P (pink-eyed dilution). Mutations in the
                     human melanosomal P gene were responsible for classic
                     phenotype of oculocutaneous albinism type 2 (OCA2).
                     Although the precise function of the P protein is unknown,
                     it was predicted to regulate the...; cd01116"
                     /db_xref="CDD:238536"
     Site            order(343..356,379..395,397..414,419..442,469..483,
                     577..589,605..619,631..649,678..693,723..742,768..780)
                     /site_type="other"
                     /note="transmembrane helices"
                     /db_xref="CDD:238536"
     CDS             1..792
                     /gene="OCA2"
                     /gene_synonym="BEY; BEY1; BEY2; BOCA; D15S12; EYCL; EYCL2;
                     EYCL3; HCL3; P; PED; SHEP1; SLC13B1"
                     /coded_by="XM_047432611.1:114..2492"
                     /db_xref="GeneID:4948"
                     /db_xref="HGNC:HGNC:8101"
                     /db_xref="MIM:611409"
ORIGIN      
        1 mhlegrdgrr ypgapavell qtsvpsglae lvagkrrlpr gaggadpshs cprgaagqss
       61 wapagqefas fltkgrshss lpqmsssrsk dscftentpl lrnslqekgs rcipvyhpef
      121 itaeesweds sadwerryll srevsglsas assekgdlld sphirlrlsk lrrcvqwlkv
      181 mglfafvvlc silfslypdq gklwqllals plenysvnls shvdstllqv dlagalvasg
      241 psrpgreehi vveltqadal gsrwrrpqqv thnwtvylnp rrsehsvmsr tfevltretv
      301 sisiraslqq tqavpllmah qylrgsvetq vtiatailag vyaliifemi lvaifsetgf
      361 fdycavkayr lsrgrvwami imlcliaavl safldnvttm llftpvtirl cevlnldprq
      421 vliaeviftn iggaataigd ppnviivsnq elrkmgldfa gftahmfigi clvllvcfpl
      481 lrllywnrkl ynkepseive lkheihvwrl taqrispasr eetavrrlll gkvlalehll
      541 arrlhtfhrq isqedknwet niqelqkkhr isdgillakc ltvlgfvifm fflnsfvpgi
      601 hldlgwiail gaiwllilad ihdfeiilhr vewatllffa alfvlmeala hlhlieyvge
      661 qtallikmvp eeqrliaaiv lvvwvsalas slidnipfta tmipvllnls hdpevglpap
      721 plmyalafga clggngtlig asanvvcagi aeqhgygfsf meffrlgfpm mvvsctvgmc
      781 yllvahvvvg wn
//
LOCUS       XP_016877752             791 aa            linear   PRI 05-AUG-2025
DEFINITION  P protein isoform X17 [Homo sapiens].
ACCESSION   XP_016877752
VERSION     XP_016877752.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022263.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..791
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..791
                     /product="P protein isoform X17"
                     /calculated_mol_wt=87842
     Region          346..782
                     /region_name="P_permease"
                     /note="Permease P (pink-eyed dilution). Mutations in the
                     human melanosomal P gene were responsible for classic
                     phenotype of oculocutaneous albinism type 2 (OCA2).
                     Although the precise function of the P protein is unknown,
                     it was predicted to regulate the...; cd01116"
                     /db_xref="CDD:238536"
     Site            order(350..353,360..373,393..410,433..449,451..468,
                     473..496,523..537,631..643,659..673,685..701,722..741,
                     767..779)
                     /site_type="other"
                     /note="transmembrane helices"
                     /db_xref="CDD:238536"
     CDS             1..791
                     /gene="OCA2"
                     /gene_synonym="BEY; BEY1; BEY2; BOCA; D15S12; EYCL; EYCL2;
                     EYCL3; HCL3; P; PED; SHEP1; SLC13B1"
                     /coded_by="XM_017022263.2:2296..4671"
                     /db_xref="GeneID:4948"
                     /db_xref="HGNC:HGNC:8101"
                     /db_xref="MIM:611409"
ORIGIN      
        1 mredwqwsmh legrdgrryp gapavellqt svpsglaelv agkrrlprga ggadpshscp
       61 rgaagqsswa pagqefasfl tkgrshsslp qmsssrskds cftentpllr nslqekgsrc
      121 ipvyhpefit aeeswedssa dwerryllsr evsglsasas sekgdlldsp hirlrlsklr
      181 rcvqwlkvmg lfafvvlcsi lfslypdqgk lwqllalspl enysvnlssh vdstllqvdl
      241 agalvasgps rpgreehivv eltqadalgs rwrrpqqvth nwtvylnprr sehsvmsrtf
      301 evltretvsi siraslqqtq avpllmahqy lrgsvetqvt iatailagvy aliifeivhr
      361 tlaamlgsla alaalavigd rpslthvvew idfetlallf gmmilvaifs etgffdycav
      421 kayrlsrgrv wamiimlcli aavlsafldn vttmllftpv tirlcevlnl dprqvliaev
      481 iftniggaat aigdppnvii vsnqelrkmg ldfagftahm figiclvllv cfpllrllyw
      541 nrklynkeps eivelkheih vwrltaqris pasreetavr rlllgkvlal ehllarrlht
      601 fhrqisqedk nwetniqelq kkhrisdgil lakcltvlgf vifmfflnsf vpgihldlgw
      661 iailgaiwll iladihdfei ilhrvewatl lffaalfvlm eipvllnlsh dpevglpapp
      721 lmyalafgac lggngtliga sanvvcagia eqhgygfsfm effrlgfpmm vvsctvgmcy
      781 llvahvvvgw n
//
LOCUS       XP_047288568             785 aa            linear   PRI 05-AUG-2025
DEFINITION  P protein isoform X18 [Homo sapiens].
ACCESSION   XP_047288568
VERSION     XP_047288568.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432612.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..785
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..785
                     /product="P protein isoform X18"
                     /calculated_mol_wt=87140
     Region          338..777
                     /region_name="P_permease"
                     /note="Permease P (pink-eyed dilution). Mutations in the
                     human melanosomal P gene were responsible for classic
                     phenotype of oculocutaneous albinism type 2 (OCA2).
                     Although the precise function of the P protein is unknown,
                     it was predicted to regulate the...; cd01116"
                     /db_xref="CDD:238536"
     Site            order(342..345,352..365,385..402,425..441,443..460,
                     465..488,515..529,623..635,651..665,677..695,724..739,
                     761..777)
                     /site_type="other"
                     /note="transmembrane helices"
                     /db_xref="CDD:238536"
     CDS             1..785
                     /gene="OCA2"
                     /gene_synonym="BEY; BEY1; BEY2; BOCA; D15S12; EYCL; EYCL2;
                     EYCL3; HCL3; P; PED; SHEP1; SLC13B1"
                     /coded_by="XM_047432612.1:114..2471"
                     /db_xref="GeneID:4948"
                     /db_xref="HGNC:HGNC:8101"
                     /db_xref="MIM:611409"
ORIGIN      
        1 mhlegrdgrr ypgapavell qtsvpsglae lvagkrrlpr gaggadpshs cprgaagqss
       61 wapagqefas fltkgrshss lpqmsssrsk dscftentpl lrnslqekgs rcipvyhpef
      121 itaeesweds sadwerryll srevsglsas assekgdlld sphirlrlsk lrrcvqwlkv
      181 mglfafvvlc silfslypdq gklwqllals plenysvnls shvdstllqv dlagalvasg
      241 psrpgreehi vveltqadal gsrwrrpqqv thnwtvylnp rrsehsvmsr tfevltretv
      301 sisiraslqq tqavpllmah qylrgsvetq vtiatailag vyaliifeiv hrtlaamlgs
      361 laalaalavi gdrpslthvv ewidfetlal lfgmmilvai fsetgffdyc avkayrlsrg
      421 rvwamiimlc liaavlsafl dnvttmllft pvtirlcevl nldprqvlia eviftnigga
      481 ataigdppnv iivsnqelrk mgldfagfta hmfigiclvl lvcfpllrll ywnrklynke
      541 pseivelkhe ihvwrltaqr ispasreeta vrrlllgkvl alehllarrl htfhrqisqe
      601 dknwetniqe lqkkhrisdg illakcltvl gfvifmffln sfvpgihldl gwiailgaiw
      661 lliladihdf eiilhrvewa tllffaalfv lmealahlhl ieyvgeqtal likmvpeeqr
      721 liaaivlvvw vsalasslid nipftatmag lpndgcvlhc wdvlspcgsc gggmelidih
      781 llled
//
LOCUS       XP_047288569             783 aa            linear   PRI 05-AUG-2025
DEFINITION  P protein isoform X19 [Homo sapiens].
ACCESSION   XP_047288569
VERSION     XP_047288569.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432613.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..783
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..783
                     /product="P protein isoform X19"
                     /calculated_mol_wt=86723
     Region          338..774
                     /region_name="P_permease"
                     /note="Permease P (pink-eyed dilution). Mutations in the
                     human melanosomal P gene were responsible for classic
                     phenotype of oculocutaneous albinism type 2 (OCA2).
                     Although the precise function of the P protein is unknown,
                     it was predicted to regulate the...; cd01116"
                     /db_xref="CDD:238536"
     Site            order(342..345,352..365,385..402,425..441,443..460,
                     465..488,515..529,623..635,651..665,677..693,714..733,
                     759..771)
                     /site_type="other"
                     /note="transmembrane helices"
                     /db_xref="CDD:238536"
     CDS             1..783
                     /gene="OCA2"
                     /gene_synonym="BEY; BEY1; BEY2; BOCA; D15S12; EYCL; EYCL2;
                     EYCL3; HCL3; P; PED; SHEP1; SLC13B1"
                     /coded_by="XM_047432613.1:114..2465"
                     /db_xref="GeneID:4948"
                     /db_xref="HGNC:HGNC:8101"
                     /db_xref="MIM:611409"
ORIGIN      
        1 mhlegrdgrr ypgapavell qtsvpsglae lvagkrrlpr gaggadpshs cprgaagqss
       61 wapagqefas fltkgrshss lpqmsssrsk dscftentpl lrnslqekgs rcipvyhpef
      121 itaeesweds sadwerryll srevsglsas assekgdlld sphirlrlsk lrrcvqwlkv
      181 mglfafvvlc silfslypdq gklwqllals plenysvnls shvdstllqv dlagalvasg
      241 psrpgreehi vveltqadal gsrwrrpqqv thnwtvylnp rrsehsvmsr tfevltretv
      301 sisiraslqq tqavpllmah qylrgsvetq vtiatailag vyaliifeiv hrtlaamlgs
      361 laalaalavi gdrpslthvv ewidfetlal lfgmmilvai fsetgffdyc avkayrlsrg
      421 rvwamiimlc liaavlsafl dnvttmllft pvtirlcevl nldprqvlia eviftnigga
      481 ataigdppnv iivsnqelrk mgldfagfta hmfigiclvl lvcfpllrll ywnrklynke
      541 pseivelkhe ihvwrltaqr ispasreeta vrrlllgkvl alehllarrl htfhrqisqe
      601 dknwetniqe lqkkhrisdg illakcltvl gfvifmffln sfvpgihldl gwiailgaiw
      661 lliladihdf eiilhrvewa tllffaalfv lmeipvllnl shdpevglpa pplmyalafg
      721 aclggngtli gasanvvcag iaeqhgygfs fmeffrlgfp mmvvsctvgm cyllvahvvv
      781 gwn
//
LOCUS       XP_016877753             780 aa            linear   PRI 05-AUG-2025
DEFINITION  P protein isoform X20 [Homo sapiens].
ACCESSION   XP_016877753
VERSION     XP_016877753.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022264.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..780
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..780
                     /product="P protein isoform X20"
                     /calculated_mol_wt=86885
     Region          346..764
                     /region_name="P_permease"
                     /note="Permease P (pink-eyed dilution). Mutations in the
                     human melanosomal P gene were responsible for classic
                     phenotype of oculocutaneous albinism type 2 (OCA2).
                     Although the precise function of the P protein is unknown,
                     it was predicted to regulate the...; cd01116"
                     /db_xref="CDD:238536"
     Site            order(350..353,360..373,393..410,433..449,451..468,
                     473..496,523..537,631..643,659..673,685..701,722..741)
                     /site_type="other"
                     /note="transmembrane helices"
                     /db_xref="CDD:238536"
     CDS             1..780
                     /gene="OCA2"
                     /gene_synonym="BEY; BEY1; BEY2; BOCA; D15S12; EYCL; EYCL2;
                     EYCL3; HCL3; P; PED; SHEP1; SLC13B1"
                     /coded_by="XM_017022264.2:2300..4642"
                     /db_xref="GeneID:4948"
                     /db_xref="HGNC:HGNC:8101"
                     /db_xref="MIM:611409"
ORIGIN      
        1 mredwqwsmh legrdgrryp gapavellqt svpsglaelv agkrrlprga ggadpshscp
       61 rgaagqsswa pagqefasfl tkgrshsslp qmsssrskds cftentpllr nslqekgsrc
      121 ipvyhpefit aeeswedssa dwerryllsr evsglsasas sekgdlldsp hirlrlsklr
      181 rcvqwlkvmg lfafvvlcsi lfslypdqgk lwqllalspl enysvnlssh vdstllqvdl
      241 agalvasgps rpgreehivv eltqadalgs rwrrpqqvth nwtvylnprr sehsvmsrtf
      301 evltretvsi siraslqqtq avpllmahqy lrgsvetqvt iatailagvy aliifeivhr
      361 tlaamlgsla alaalavigd rpslthvvew idfetlallf gmmilvaifs etgffdycav
      421 kayrlsrgrv wamiimlcli aavlsafldn vttmllftpv tirlcevlnl dprqvliaev
      481 iftniggaat aigdppnvii vsnqelrkmg ldfagftahm figiclvllv cfpllrllyw
      541 nrklynkeps eivelkheih vwrltaqris pasreetavr rlllgkvlal ehllarrlht
      601 fhrqisqedk nwetniqelq kkhrisdgil lakcltvlgf vifmfflnsf vpgihldlgw
      661 iailgaiwll iladihdfei ilhrvewatl lffaalfvlm eipvllnlsh dpevglpapp
      721 lmyalafgac lggngtliga sanvvcagia eqhgygfsfm effrkreret rdvlaqrkal
//
LOCUS       XP_047288570             772 aa            linear   PRI 05-AUG-2025
DEFINITION  P protein isoform X21 [Homo sapiens].
ACCESSION   XP_047288570
VERSION     XP_047288570.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432614.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..772
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..772
                     /product="P protein isoform X21"
                     /calculated_mol_wt=85765
     Region          338..756
                     /region_name="P_permease"
                     /note="Permease P (pink-eyed dilution). Mutations in the
                     human melanosomal P gene were responsible for classic
                     phenotype of oculocutaneous albinism type 2 (OCA2).
                     Although the precise function of the P protein is unknown,
                     it was predicted to regulate the...; cd01116"
                     /db_xref="CDD:238536"
     Site            order(342..345,352..365,385..402,425..441,443..460,
                     465..488,515..529,623..635,651..665,677..693,714..733)
                     /site_type="other"
                     /note="transmembrane helices"
                     /db_xref="CDD:238536"
     CDS             1..772
                     /gene="OCA2"
                     /gene_synonym="BEY; BEY1; BEY2; BOCA; D15S12; EYCL; EYCL2;
                     EYCL3; HCL3; P; PED; SHEP1; SLC13B1"
                     /coded_by="XM_047432614.1:114..2432"
                     /db_xref="GeneID:4948"
                     /db_xref="HGNC:HGNC:8101"
                     /db_xref="MIM:611409"
ORIGIN      
        1 mhlegrdgrr ypgapavell qtsvpsglae lvagkrrlpr gaggadpshs cprgaagqss
       61 wapagqefas fltkgrshss lpqmsssrsk dscftentpl lrnslqekgs rcipvyhpef
      121 itaeesweds sadwerryll srevsglsas assekgdlld sphirlrlsk lrrcvqwlkv
      181 mglfafvvlc silfslypdq gklwqllals plenysvnls shvdstllqv dlagalvasg
      241 psrpgreehi vveltqadal gsrwrrpqqv thnwtvylnp rrsehsvmsr tfevltretv
      301 sisiraslqq tqavpllmah qylrgsvetq vtiatailag vyaliifeiv hrtlaamlgs
      361 laalaalavi gdrpslthvv ewidfetlal lfgmmilvai fsetgffdyc avkayrlsrg
      421 rvwamiimlc liaavlsafl dnvttmllft pvtirlcevl nldprqvlia eviftnigga
      481 ataigdppnv iivsnqelrk mgldfagfta hmfigiclvl lvcfpllrll ywnrklynke
      541 pseivelkhe ihvwrltaqr ispasreeta vrrlllgkvl alehllarrl htfhrqisqe
      601 dknwetniqe lqkkhrisdg illakcltvl gfvifmffln sfvpgihldl gwiailgaiw
      661 lliladihdf eiilhrvewa tllffaalfv lmeipvllnl shdpevglpa pplmyalafg
      721 aclggngtli gasanvvcag iaeqhgygfs fmeffrkrer etrdvlaqrk al
//
LOCUS       XP_047288571             769 aa            linear   PRI 05-AUG-2025
DEFINITION  P protein isoform X22 [Homo sapiens].
ACCESSION   XP_047288571
VERSION     XP_047288571.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432615.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..769
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..769
                     /product="P protein isoform X22"
                     /calculated_mol_wt=85930
     Region          346..761
                     /region_name="P_permease"
                     /note="Permease P (pink-eyed dilution). Mutations in the
                     human melanosomal P gene were responsible for classic
                     phenotype of oculocutaneous albinism type 2 (OCA2).
                     Although the precise function of the P protein is unknown,
                     it was predicted to regulate the...; cd01116"
                     /db_xref="CDD:238536"
     Site            order(350..353,369..386,409..425,427..444,449..472,
                     499..513,607..619,635..649,661..679,708..723,745..761)
                     /site_type="other"
                     /note="transmembrane helices"
                     /db_xref="CDD:238536"
     CDS             1..769
                     /gene="OCA2"
                     /gene_synonym="BEY; BEY1; BEY2; BOCA; D15S12; EYCL; EYCL2;
                     EYCL3; HCL3; P; PED; SHEP1; SLC13B1"
                     /coded_by="XM_047432615.1:2297..4606"
                     /db_xref="GeneID:4948"
                     /db_xref="HGNC:HGNC:8101"
                     /db_xref="MIM:611409"
ORIGIN      
        1 mredwqwsmh legrdgrryp gapavellqt svpsglaelv agkrrlprga ggadpshscp
       61 rgaagqsswa pagqefasfl tkgrshsslp qmsssrskds cftentpllr nslqekgsrc
      121 ipvyhpefit aeeswedssa dwerryllsr evsglsasas sekgdlldsp hirlrlsklr
      181 rcvqwlkvmg lfafvvlcsi lfslypdqgk lwqllalspl enysvnlssh vdstllqvdl
      241 agalvasgps rpgreehivv eltqadalgs rwrrpqqvth nwtvylnprr sehsvmsrtf
      301 evltretvsi siraslqqtq avpllmahqy lrgsvetqvt iatailagvy aliiferpsl
      361 thvvewidfe tlallfgmmi lvaifsetgf fdycavkayr lsrgrvwami imlcliaavl
      421 safldnvttm llftpvtirl cevlnldprq vliaeviftn iggaataigd ppnviivsnq
      481 elrkmgldfa gftahmfigi clvllvcfpl lrllywnrkl ynkepseive lkheihvwrl
      541 taqrispasr eetavrrlll gkvlalehll arrlhtfhrq isqedknwet niqelqkkhr
      601 isdgillakc ltvlgfvifm fflnsfvpgi hldlgwiail gaiwllilad ihdfeiilhr
      661 vewatllffa alfvlmeala hlhlieyvge qtallikmvp eeqrliaaiv lvvwvsalas
      721 slidnipfta tmaglpndgc vlhcwdvlsp cgscgggmel idihllled
//
LOCUS       XP_047288572             767 aa            linear   PRI 05-AUG-2025
DEFINITION  P protein isoform X23 [Homo sapiens].
ACCESSION   XP_047288572
VERSION     XP_047288572.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432616.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..767
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..767
                     /product="P protein isoform X23"
                     /calculated_mol_wt=85512
     Region          346..758
                     /region_name="P_permease"
                     /note="Permease P (pink-eyed dilution). Mutations in the
                     human melanosomal P gene were responsible for classic
                     phenotype of oculocutaneous albinism type 2 (OCA2).
                     Although the precise function of the P protein is unknown,
                     it was predicted to regulate the...; cd01116"
                     /db_xref="CDD:238536"
     Site            order(350..353,369..386,409..425,427..444,449..472,
                     499..513,607..619,635..649,661..677,698..717,743..755)
                     /site_type="other"
                     /note="transmembrane helices"
                     /db_xref="CDD:238536"
     CDS             1..767
                     /gene="OCA2"
                     /gene_synonym="BEY; BEY1; BEY2; BOCA; D15S12; EYCL; EYCL2;
                     EYCL3; HCL3; P; PED; SHEP1; SLC13B1"
                     /coded_by="XM_047432616.1:2295..4598"
                     /db_xref="GeneID:4948"
                     /db_xref="HGNC:HGNC:8101"
                     /db_xref="MIM:611409"
ORIGIN      
        1 mredwqwsmh legrdgrryp gapavellqt svpsglaelv agkrrlprga ggadpshscp
       61 rgaagqsswa pagqefasfl tkgrshsslp qmsssrskds cftentpllr nslqekgsrc
      121 ipvyhpefit aeeswedssa dwerryllsr evsglsasas sekgdlldsp hirlrlsklr
      181 rcvqwlkvmg lfafvvlcsi lfslypdqgk lwqllalspl enysvnlssh vdstllqvdl
      241 agalvasgps rpgreehivv eltqadalgs rwrrpqqvth nwtvylnprr sehsvmsrtf
      301 evltretvsi siraslqqtq avpllmahqy lrgsvetqvt iatailagvy aliiferpsl
      361 thvvewidfe tlallfgmmi lvaifsetgf fdycavkayr lsrgrvwami imlcliaavl
      421 safldnvttm llftpvtirl cevlnldprq vliaeviftn iggaataigd ppnviivsnq
      481 elrkmgldfa gftahmfigi clvllvcfpl lrllywnrkl ynkepseive lkheihvwrl
      541 taqrispasr eetavrrlll gkvlalehll arrlhtfhrq isqedknwet niqelqkkhr
      601 isdgillakc ltvlgfvifm fflnsfvpgi hldlgwiail gaiwllilad ihdfeiilhr
      661 vewatllffa alfvlmeipv llnlshdpev glpapplmya lafgaclggn gtligasanv
      721 vcagiaeqhg ygfsfmeffr lgfpmmvvsc tvgmcyllva hvvvgwn
//
LOCUS       XP_047288573             759 aa            linear   PRI 05-AUG-2025
DEFINITION  P protein isoform X24 [Homo sapiens].
ACCESSION   XP_047288573
VERSION     XP_047288573.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432617.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..759
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..759
                     /product="P protein isoform X24"
                     /calculated_mol_wt=84393
     Region          338..750
                     /region_name="P_permease"
                     /note="Permease P (pink-eyed dilution). Mutations in the
                     human melanosomal P gene were responsible for classic
                     phenotype of oculocutaneous albinism type 2 (OCA2).
                     Although the precise function of the P protein is unknown,
                     it was predicted to regulate the...; cd01116"
                     /db_xref="CDD:238536"
     Site            order(342..345,361..378,401..417,419..436,441..464,
                     491..505,599..611,627..641,653..669,690..709,735..747)
                     /site_type="other"
                     /note="transmembrane helices"
                     /db_xref="CDD:238536"
     CDS             1..759
                     /gene="OCA2"
                     /gene_synonym="BEY; BEY1; BEY2; BOCA; D15S12; EYCL; EYCL2;
                     EYCL3; HCL3; P; PED; SHEP1; SLC13B1"
                     /coded_by="XM_047432617.1:114..2393"
                     /db_xref="GeneID:4948"
                     /db_xref="HGNC:HGNC:8101"
                     /db_xref="MIM:611409"
ORIGIN      
        1 mhlegrdgrr ypgapavell qtsvpsglae lvagkrrlpr gaggadpshs cprgaagqss
       61 wapagqefas fltkgrshss lpqmsssrsk dscftentpl lrnslqekgs rcipvyhpef
      121 itaeesweds sadwerryll srevsglsas assekgdlld sphirlrlsk lrrcvqwlkv
      181 mglfafvvlc silfslypdq gklwqllals plenysvnls shvdstllqv dlagalvasg
      241 psrpgreehi vveltqadal gsrwrrpqqv thnwtvylnp rrsehsvmsr tfevltretv
      301 sisiraslqq tqavpllmah qylrgsvetq vtiatailag vyaliiferp slthvvewid
      361 fetlallfgm milvaifset gffdycavka yrlsrgrvwa miimlcliaa vlsafldnvt
      421 tmllftpvti rlcevlnldp rqvliaevif tniggaatai gdppnviivs nqelrkmgld
      481 fagftahmfi giclvllvcf pllrllywnr klynkepsei velkheihvw rltaqrispa
      541 sreetavrrl llgkvlaleh llarrlhtfh rqisqedknw etniqelqkk hrisdgilla
      601 kcltvlgfvi fmfflnsfvp gihldlgwia ilgaiwllil adihdfeiil hrvewatllf
      661 faalfvlmei pvllnlshdp evglpapplm yalafgaclg gngtligasa nvvcagiaeq
      721 hgygfsfmef frlgfpmmvv sctvgmcyll vahvvvgwn
//
LOCUS       XP_047288574             748 aa            linear   PRI 05-AUG-2025
DEFINITION  P protein isoform X25 [Homo sapiens].
ACCESSION   XP_047288574
VERSION     XP_047288574.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432618.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..748
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..748
                     /product="P protein isoform X25"
                     /calculated_mol_wt=83435
     Region          338..732
                     /region_name="P_permease"
                     /note="Permease P (pink-eyed dilution). Mutations in the
                     human melanosomal P gene were responsible for classic
                     phenotype of oculocutaneous albinism type 2 (OCA2).
                     Although the precise function of the P protein is unknown,
                     it was predicted to regulate the...; cd01116"
                     /db_xref="CDD:238536"
     CDS             1..748
                     /gene="OCA2"
                     /gene_synonym="BEY; BEY1; BEY2; BOCA; D15S12; EYCL; EYCL2;
                     EYCL3; HCL3; P; PED; SHEP1; SLC13B1"
                     /coded_by="XM_047432618.1:114..2360"
                     /db_xref="GeneID:4948"
                     /db_xref="HGNC:HGNC:8101"
                     /db_xref="MIM:611409"
ORIGIN      
        1 mhlegrdgrr ypgapavell qtsvpsglae lvagkrrlpr gaggadpshs cprgaagqss
       61 wapagqefas fltkgrshss lpqmsssrsk dscftentpl lrnslqekgs rcipvyhpef
      121 itaeesweds sadwerryll srevsglsas assekgdlld sphirlrlsk lrrcvqwlkv
      181 mglfafvvlc silfslypdq gklwqllals plenysvnls shvdstllqv dlagalvasg
      241 psrpgreehi vveltqadal gsrwrrpqqv thnwtvylnp rrsehsvmsr tfevltretv
      301 sisiraslqq tqavpllmah qylrgsvetq vtiatailag vyaliiferp slthvvewid
      361 fetlallfgm milvaifset gffdycavka yrlsrgrvwa miimlcliaa vlsafldnvt
      421 tmllftpvti rlcevlnldp rqvliaevif tniggaatai gdppnviivs nqelrkmgld
      481 fagftahmfi giclvllvcf pllrllywnr klynkepsei velkheihvw rltaqrispa
      541 sreetavrrl llgkvlaleh llarrlhtfh rqisqedknw etniqelqkk hrisdgilla
      601 kcltvlgfvi fmfflnsfvp gihldlgwia ilgaiwllil adihdfeiil hrvewatllf
      661 faalfvlmei pvllnlshdp evglpapplm yalafgaclg gngtligasa nvvcagiaeq
      721 hgygfsfmef frkreretrd vlaqrkal
//
LOCUS       XP_047288575             726 aa            linear   PRI 05-AUG-2025
DEFINITION  P protein isoform X26 [Homo sapiens].
ACCESSION   XP_047288575
VERSION     XP_047288575.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432619.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..726
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..726
                     /product="P protein isoform X26"
                     /calculated_mol_wt=80878
     Region          343..710
                     /region_name="P_permease"
                     /note="Permease P (pink-eyed dilution). Mutations in the
                     human melanosomal P gene were responsible for classic
                     phenotype of oculocutaneous albinism type 2 (OCA2).
                     Although the precise function of the P protein is unknown,
                     it was predicted to regulate the...; cd01116"
                     /db_xref="CDD:238536"
     CDS             1..726
                     /gene="OCA2"
                     /gene_synonym="BEY; BEY1; BEY2; BOCA; D15S12; EYCL; EYCL2;
                     EYCL3; HCL3; P; PED; SHEP1; SLC13B1"
                     /coded_by="XM_047432619.1:114..2294"
                     /db_xref="GeneID:4948"
                     /db_xref="HGNC:HGNC:8101"
                     /db_xref="MIM:611409"
ORIGIN      
        1 mhlegrdgrr ypgapavell qtsvpsglae lvagkrrlpr gaggadpshs cprgaagqss
       61 wapagqefas fltkgrshss lpqmsssrsk dscftentpl lrnslqekgs rcipvyhpef
      121 itaeesweds sadwerryll srevsglsas assekgdlld sphirlrlsk lrrcvqwlkv
      181 mglfafvvlc silfslypdq gklwqllals plenysvnls shvdstllqv dlagalvasg
      241 psrpgreehi vveltqadal gsrwrrpqqv thnwtvylnp rrsehsvmsr tfevltretv
      301 sisiraslqq tqavpllmah qylrgsvetq vtiatailag vyaliifemi lvaifsetgf
      361 fdycavkayr lsrgrvwami imlcliaavl safldnvttm llftpvtirl cevlnldprq
      421 vliaeviftn iggaataigd ppnviivsnq elrkmgldfa gftahmfigi clvllvcfpl
      481 lrllywnrkl ynkepseive lkheihvwrl taqrispasr eetavrrlll gkvlalehll
      541 arrlhtfhrq isqedknwet niqelqkkhr isdgillakc ltvlgfvifm fflnsfvpgi
      601 hldlgwiail gaiwllilad ihdfeiilhr vewatllffa alfvlmeipv llnlshdpev
      661 glpapplmya lafgaclggn gtligasanv vcagiaeqhg ygfsfmeffr kreretrdvl
      721 aqrkal
//
LOCUS       XP_016877754             676 aa            linear   PRI 05-AUG-2025
DEFINITION  P protein isoform X27 [Homo sapiens].
ACCESSION   XP_016877754
VERSION     XP_016877754.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022265.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..676
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..676
                     /product="P protein isoform X27"
                     /calculated_mol_wt=75301
     Region          346..>652
                     /region_name="ArsB_NhaD_permease"
                     /note="Anion permease ArsB/NhaD. These permeases have been
                     shown to translocate sodium, arsenate, antimonite, sulfate
                     and organic anions across biological membranes in all
                     three kingdoms of life. A typical anion permease contains
                     8-13 transmembrane helices...; cl21473"
                     /db_xref="CDD:473875"
     CDS             1..676
                     /gene="OCA2"
                     /gene_synonym="BEY; BEY1; BEY2; BOCA; D15S12; EYCL; EYCL2;
                     EYCL3; HCL3; P; PED; SHEP1; SLC13B1"
                     /coded_by="XM_017022265.2:2301..4331"
                     /db_xref="GeneID:4948"
                     /db_xref="HGNC:HGNC:8101"
                     /db_xref="MIM:611409"
ORIGIN      
        1 mredwqwsmh legrdgrryp gapavellqt svpsglaelv agkrrlprga ggadpshscp
       61 rgaagqsswa pagqefasfl tkgrshsslp qmsssrskds cftentpllr nslqekgsrc
      121 ipvyhpefit aeeswedssa dwerryllsr evsglsasas sekgdlldsp hirlrlsklr
      181 rcvqwlkvmg lfafvvlcsi lfslypdqgk lwqllalspl enysvnlssh vdstllqvdl
      241 agalvasgps rpgreehivv eltqadalgs rwrrpqqvth nwtvylnprr sehsvmsrtf
      301 evltretvsi siraslqqtq avpllmahqy lrgsvetqvt iatailagvy aliifeivhr
      361 tlaamlgsla alaalavigd rpslthvvew idfetlallf gmmilvaifs etgffdycav
      421 kayrlsrgrv wamiimlcli aavlsafldn vttmllftpv tirlcevlnl dprqvliaev
      481 iftniggaat aigdppnvii vsnqelrkmg ldfagftahm figiclvllv cfpllrllyw
      541 nrklynkeps eivelkheih vwrltaqris pasreetavr rlllgkvlal ehllarrlht
      601 fhrqisqedk nwetniqelq kkhrisdgil lakcltvlgf vifmfflnsf vpgihldlgg
      661 lglvqagryy lstpes
//
LOCUS       XP_047288576            1431 aa            linear   PRI 05-AUG-2025
DEFINITION  S phase cyclin A-associated protein in the endoplasmic reticulum
            isoform X1 [Homo sapiens].
ACCESSION   XP_047288576
VERSION     XP_047288576.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432620.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1431
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1431
                     /product="S phase cyclin A-associated protein in the
                     endoplasmic reticulum isoform X1"
                     /calculated_mol_wt=161264
     Region          114..211
                     /region_name="SCAPER_N"
                     /note="S phase cyclin A-associated protein in the
                     endoplasmic reticulum; pfam16501"
                     /db_xref="CDD:406813"
     Region          <370..742
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <568..>802
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          821..853
                     /region_name="ZnF_U1"
                     /note="U1-like zinc finger; smart00451"
                     /db_xref="CDD:197732"
     CDS             1..1431
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /coded_by="XM_047432620.1:87..4382"
                     /db_xref="GeneID:49855"
                     /db_xref="HGNC:HGNC:13081"
                     /db_xref="MIM:611611"
ORIGIN      
        1 mralrpggak slshlgvvgp sllpllllfs ktalpwrlss tpfsrshtpw vyvindlgie
       61 enlkndgkpk cqtggkskrt iqgthkttkq stavdckits sttgdkhfdk sptktrhprk
      121 idlrarywaf lfdnlrravd eiyvtcesdq svveckevlm mldnyvrdfk alidwiqlqe
      181 klektdaqsr ptslawevkk mspgrhvips pstdrinvts narrslnfgg stgtvpaprl
      241 aptgvswadk vkahhtgsta sseitpaqsc ppmtvqkasr knerkdaegw etvqrgrpir
      301 srstavmpkv slateatrsk ddsdkenvcl lpdesiqkgq fvgdgtsnti eshpkdslhs
      361 cdhplaektq ftvstlddvk nsgsirdnyv rtseisavhi dtecvsvmlq agtpplqvne
      421 ekfpaekari enemdpsdis nvsaanlsma evlakkeela drlekaneea iasaiaeeeq
      481 ltreieaeen ndinietdnd sdfsasmgsg svsfcgmsmd wndvladyea reswrqntsw
      541 gdiveeepar ppghgihmhe klsspsrkrt iaeskkkhee kqmkaqqlre klreektlkl
      601 qkllerekdv rkwkeelldq rrrmmeekll haefkrevql qaivkkaqee eakvneiafi
      661 ntleaqnkrh dvlsklkeye qrlnelqeer qrrqeekqar deavqerkra leaerqarve
      721 ellmkrkeqe arieqqrqek ekaredaare rardreerla altaaqqeam eelqkkiqlk
      781 hdesirrhme qieqrkekaa elssgrhant dyapkltpye rkkqcslcnv lissevylfs
      841 hvkgrkhqqa vrentsiqgr elsdeevehl slkkyiidiv vestapaeal kdgeerqknk
      901 kkakkikarm nfrakeyesl metknsgsds pykaklqrla kdllkqvqvq dsgswannkv
      961 saldrtlgei trilekenva dqiafqaagg ltalehilqa vvpatnvntv lrippkslcn
     1021 ainvynltcn ncsencsdvl fsnkitflmd llihqltvyv pdenntilgr ntnkqvfegl
     1081 ttgllkvsav vlgclianrp dgncqpatpk iptqemknkp sqgdpfnnrv qdlisyvvnm
     1141 glidklcacf lsvqgpvden pkmaiflqha agllhamctl cfavtgrsys ifdnnrqdpt
     1201 gltaalqatd lagvlhmlyc vlfhgtildp staspkenyt qntiqvaiqs lrffnsfaal
     1261 hlpafqsivg aeglslafrh massllghcs qvscesllhe vivcvgyftv nhpdnqvivq
     1321 sgrhptvlqk lcqlpfqyfs dprlikvlfp sliaacynnh qnkiileqem scvllatfiq
     1381 dlaqtpgqae nqpyqpkgkc lgsqdylela nrfpqqawee arqfflkkek k
//
LOCUS       XP_047288577            1425 aa            linear   PRI 05-AUG-2025
DEFINITION  S phase cyclin A-associated protein in the endoplasmic reticulum
            isoform X2 [Homo sapiens].
ACCESSION   XP_047288577
VERSION     XP_047288577.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432621.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1425
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1425
                     /product="S phase cyclin A-associated protein in the
                     endoplasmic reticulum isoform X2"
                     /calculated_mol_wt=160708
     Region          114..211
                     /region_name="SCAPER_N"
                     /note="S phase cyclin A-associated protein in the
                     endoplasmic reticulum; pfam16501"
                     /db_xref="CDD:406813"
     Region          <370..736
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <562..>796
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          815..847
                     /region_name="ZnF_U1"
                     /note="U1-like zinc finger; smart00451"
                     /db_xref="CDD:197732"
     CDS             1..1425
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /coded_by="XM_047432621.1:87..4364"
                     /db_xref="GeneID:49855"
                     /db_xref="HGNC:HGNC:13081"
                     /db_xref="MIM:611611"
ORIGIN      
        1 mralrpggak slshlgvvgp sllpllllfs ktalpwrlss tpfsrshtpw vyvindlgie
       61 enlkndgkpk cqtggkskrt iqgthkttkq stavdckits sttgdkhfdk sptktrhprk
      121 idlrarywaf lfdnlrravd eiyvtcesdq svveckevlm mldnyvrdfk alidwiqlqe
      181 klektdaqsr ptslawevkk mspgrhvips pstdrinvts narrslnfgg stgtvpaprl
      241 aptgvswadk vkahhtgsta sseitpaqsc ppmtvqkasr knerkdaegw etvqrgrpir
      301 srstavmpkv slateatrsk ddsdkenvcl lpdesiqkgq fvgdgtsnti eshpkdslhs
      361 cdhplaektq ftvstlddvk nsgsirdnyv rtseisavhi dtecvsvmlq agtpplqvne
      421 ekfpaekari enemdpsdis nsmaevlakk eeladrleka neeaiasaia eeeqltreie
      481 aeenndinie tdndsdfsas mgsgsvsfcg msmdwndvla dyeareswrq ntswgdivee
      541 eparppghgi hmheklssps rkrtiaeskk kheekqmkaq qlreklreek tlklqkller
      601 ekdvrkwkee lldqrrrmme ekllhaefkr evqlqaivkk aqeeeakvne iafintleaq
      661 nkrhdvlskl keyeqrlnel qeerqrrqee kqardeavqe rkraleaerq arveellmkr
      721 keqearieqq rqekekared aarerardre erlaaltaaq qeameelqkk iqlkhdesir
      781 rhmeqieqrk ekaaelssgr hantdyapkl tpyerkkqcs lcnvlissev ylfshvkgrk
      841 hqqavrents iqgrelsdee vehlslkkyi idivvestap aealkdgeer qknkkkakki
      901 karmnfrake yeslmetkns gsdspykakl qrlakdllkq vqvqdsgswa nnkvsaldrt
      961 lgeitrilek envadqiafq aaggltaleh ilqavvpatn vntvlrippk slcnainvyn
     1021 ltcnncsenc sdvlfsnkit flmdllihql tvyvpdennt ilgrntnkqv feglttgllk
     1081 vsavvlgcli anrpdgncqp atpkiptqem knkpsqgdpf nnrvqdlisy vvnmglidkl
     1141 cacflsvqgp vdenpkmaif lqhaagllha mctlcfavtg rsysifdnnr qdptgltaal
     1201 qatdlagvlh mlycvlfhgt ildpstaspk enytqntiqv aiqslrffns faalhlpafq
     1261 sivgaeglsl afrhmassll ghcsqvsces llhevivcvg yftvnhpdnq vivqsgrhpt
     1321 vlqklcqlpf qyfsdprlik vlfpsliaac ynnhqnkiil eqemscvlla tfiqdlaqtp
     1381 gqaenqpyqp kgkclgsqdy lelanrfpqq aweearqffl kkekk
//
LOCUS       XP_047288578            1390 aa            linear   PRI 05-AUG-2025
DEFINITION  S phase cyclin A-associated protein in the endoplasmic reticulum
            isoform X3 [Homo sapiens].
ACCESSION   XP_047288578
VERSION     XP_047288578.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432622.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1390
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1390
                     /product="S phase cyclin A-associated protein in the
                     endoplasmic reticulum isoform X3"
                     /calculated_mol_wt=156782
     Region          73..170
                     /region_name="SCAPER_N"
                     /note="S phase cyclin A-associated protein in the
                     endoplasmic reticulum; pfam16501"
                     /db_xref="CDD:406813"
     Region          <329..701
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <527..>761
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          780..812
                     /region_name="ZnF_U1"
                     /note="U1-like zinc finger; smart00451"
                     /db_xref="CDD:197732"
     CDS             1..1390
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /coded_by="XM_047432622.1:138..4310"
                     /db_xref="GeneID:49855"
                     /db_xref="HGNC:HGNC:13081"
                     /db_xref="MIM:611611"
ORIGIN      
        1 maagshtpwv yvindlgiee nlkndgkpkc qtggkskrti qgthkttkqs tavdckitss
       61 ttgdkhfdks ptktrhprki dlrarywafl fdnlrravde iyvtcesdqs vveckevlmm
      121 ldnyvrdfka lidwiqlqek lektdaqsrp tslawevkkm spgrhvipsp stdrinvtsn
      181 arrslnfggs tgtvpaprla ptgvswadkv kahhtgstas seitpaqscp pmtvqkasrk
      241 nerkdaegwe tvqrgrpirs rstavmpkvs lateatrskd dsdkenvcll pdesiqkgqf
      301 vgdgtsntie shpkdslhsc dhplaektqf tvstlddvkn sgsirdnyvr tseisavhid
      361 tecvsvmlqa gtpplqvnee kfpaekarie nemdpsdisn vsaanlsmae vlakkeelad
      421 rlekaneeai asaiaeeeql treieaeenn dinietdnds dfsasmgsgs vsfcgmsmdw
      481 ndvladyear eswrqntswg diveeeparp pghgihmhek lsspsrkrti aeskkkheek
      541 qmkaqqlrek lreektlklq kllerekdvr kwkeelldqr rrmmeekllh aefkrevqlq
      601 aivkkaqeee akvneiafin tleaqnkrhd vlsklkeyeq rlnelqeerq rrqeekqard
      661 eavqerkral eaerqarvee llmkrkeqea rieqqrqeke karedaarer ardreerlaa
      721 ltaaqqeame elqkkiqlkh desirrhmeq ieqrkekaae lssgrhantd yapkltpyer
      781 kkqcslcnvl issevylfsh vkgrkhqqav rentsiqgre lsdeevehls lkkyiidivv
      841 estapaealk dgeerqknkk kakkikarmn frakeyeslm etknsgsdsp ykaklqrlak
      901 dllkqvqvqd sgswannkvs aldrtlgeit rilekenvad qiafqaaggl talehilqav
      961 vpatnvntvl rippkslcna invynltcnn csencsdvlf snkitflmdl lihqltvyvp
     1021 denntilgrn tnkqvfeglt tgllkvsavv lgclianrpd gncqpatpki ptqemknkps
     1081 qgdpfnnrvq dlisyvvnmg lidklcacfl svqgpvdenp kmaiflqhaa gllhamctlc
     1141 favtgrsysi fdnnrqdptg ltaalqatdl agvlhmlycv lfhgtildps taspkenytq
     1201 ntiqvaiqsl rffnsfaalh lpafqsivga eglslafrhm assllghcsq vscesllhev
     1261 ivcvgyftvn hpdnqvivqs grhptvlqkl cqlpfqyfsd prlikvlfps liaacynnhq
     1321 nkiileqems cvllatfiqd laqtpgqaen qpyqpkgkcl gsqdylelan rfpqqaweea
     1381 rqfflkkekk
//
LOCUS       XP_047288579            1384 aa            linear   PRI 05-AUG-2025
DEFINITION  S phase cyclin A-associated protein in the endoplasmic reticulum
            isoform X4 [Homo sapiens].
ACCESSION   XP_047288579
VERSION     XP_047288579.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432623.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1384
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1384
                     /product="S phase cyclin A-associated protein in the
                     endoplasmic reticulum isoform X4"
                     /calculated_mol_wt=156227
     Region          73..170
                     /region_name="SCAPER_N"
                     /note="S phase cyclin A-associated protein in the
                     endoplasmic reticulum; pfam16501"
                     /db_xref="CDD:406813"
     Region          <329..695
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <521..>755
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          774..806
                     /region_name="ZnF_U1"
                     /note="U1-like zinc finger; smart00451"
                     /db_xref="CDD:197732"
     CDS             1..1384
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /coded_by="XM_047432623.1:138..4292"
                     /db_xref="GeneID:49855"
                     /db_xref="HGNC:HGNC:13081"
                     /db_xref="MIM:611611"
ORIGIN      
        1 maagshtpwv yvindlgiee nlkndgkpkc qtggkskrti qgthkttkqs tavdckitss
       61 ttgdkhfdks ptktrhprki dlrarywafl fdnlrravde iyvtcesdqs vveckevlmm
      121 ldnyvrdfka lidwiqlqek lektdaqsrp tslawevkkm spgrhvipsp stdrinvtsn
      181 arrslnfggs tgtvpaprla ptgvswadkv kahhtgstas seitpaqscp pmtvqkasrk
      241 nerkdaegwe tvqrgrpirs rstavmpkvs lateatrskd dsdkenvcll pdesiqkgqf
      301 vgdgtsntie shpkdslhsc dhplaektqf tvstlddvkn sgsirdnyvr tseisavhid
      361 tecvsvmlqa gtpplqvnee kfpaekarie nemdpsdisn smaevlakke eladrlekan
      421 eeaiasaiae eeqltreiea eenndiniet dndsdfsasm gsgsvsfcgm smdwndvlad
      481 yeareswrqn tswgdiveee parppghgih mheklsspsr krtiaeskkk heekqmkaqq
      541 lreklreekt lklqkllere kdvrkwkeel ldqrrrmmee kllhaefkre vqlqaivkka
      601 qeeeakvnei afintleaqn krhdvlsklk eyeqrlnelq eerqrrqeek qardeavqer
      661 kraleaerqa rveellmkrk eqearieqqr qekekareda arerardree rlaaltaaqq
      721 eameelqkki qlkhdesirr hmeqieqrke kaaelssgrh antdyapklt pyerkkqcsl
      781 cnvlissevy lfshvkgrkh qqavrentsi qgrelsdeev ehlslkkyii divvestapa
      841 ealkdgeerq knkkkakkik armnfrakey eslmetknsg sdspykaklq rlakdllkqv
      901 qvqdsgswan nkvsaldrtl geitrileke nvadqiafqa aggltalehi lqavvpatnv
      961 ntvlrippks lcnainvynl tcnncsencs dvlfsnkitf lmdllihqlt vyvpdennti
     1021 lgrntnkqvf eglttgllkv savvlgclia nrpdgncqpa tpkiptqemk nkpsqgdpfn
     1081 nrvqdlisyv vnmglidklc acflsvqgpv denpkmaifl qhaagllham ctlcfavtgr
     1141 sysifdnnrq dptgltaalq atdlagvlhm lycvlfhgti ldpstaspke nytqntiqva
     1201 iqslrffnsf aalhlpafqs ivgaeglsla frhmassllg hcsqvscesl lhevivcvgy
     1261 ftvnhpdnqv ivqsgrhptv lqklcqlpfq yfsdprlikv lfpsliaacy nnhqnkiile
     1321 qemscvllat fiqdlaqtpg qaenqpyqpk gkclgsqdyl elanrfpqqa weearqfflk
     1381 kekk
//
LOCUS       XP_047288580            1379 aa            linear   PRI 05-AUG-2025
DEFINITION  S phase cyclin A-associated protein in the endoplasmic reticulum
            isoform X5 [Homo sapiens].
ACCESSION   XP_047288580
VERSION     XP_047288580.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432624.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1379
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1379
                     /product="S phase cyclin A-associated protein in the
                     endoplasmic reticulum isoform X5"
                     /calculated_mol_wt=155739
     Region          114..211
                     /region_name="SCAPER_N"
                     /note="S phase cyclin A-associated protein in the
                     endoplasmic reticulum; pfam16501"
                     /db_xref="CDD:406813"
     Region          <370..742
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <568..>802
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          821..853
                     /region_name="ZnF_U1"
                     /note="U1-like zinc finger; smart00451"
                     /db_xref="CDD:197732"
     CDS             1..1379
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /coded_by="XM_047432624.1:87..4226"
                     /db_xref="GeneID:49855"
                     /db_xref="HGNC:HGNC:13081"
                     /db_xref="MIM:611611"
ORIGIN      
        1 mralrpggak slshlgvvgp sllpllllfs ktalpwrlss tpfsrshtpw vyvindlgie
       61 enlkndgkpk cqtggkskrt iqgthkttkq stavdckits sttgdkhfdk sptktrhprk
      121 idlrarywaf lfdnlrravd eiyvtcesdq svveckevlm mldnyvrdfk alidwiqlqe
      181 klektdaqsr ptslawevkk mspgrhvips pstdrinvts narrslnfgg stgtvpaprl
      241 aptgvswadk vkahhtgsta sseitpaqsc ppmtvqkasr knerkdaegw etvqrgrpir
      301 srstavmpkv slateatrsk ddsdkenvcl lpdesiqkgq fvgdgtsnti eshpkdslhs
      361 cdhplaektq ftvstlddvk nsgsirdnyv rtseisavhi dtecvsvmlq agtpplqvne
      421 ekfpaekari enemdpsdis nvsaanlsma evlakkeela drlekaneea iasaiaeeeq
      481 ltreieaeen ndinietdnd sdfsasmgsg svsfcgmsmd wndvladyea reswrqntsw
      541 gdiveeepar ppghgihmhe klsspsrkrt iaeskkkhee kqmkaqqlre klreektlkl
      601 qkllerekdv rkwkeelldq rrrmmeekll haefkrevql qaivkkaqee eakvneiafi
      661 ntleaqnkrh dvlsklkeye qrlnelqeer qrrqeekqar deavqerkra leaerqarve
      721 ellmkrkeqe arieqqrqek ekaredaare rardreerla altaaqqeam eelqkkiqlk
      781 hdesirrhme qieqrkekaa elssgrhant dyapkltpye rkkqcslcnv lissevylfs
      841 hvkgrkhqqa vrentsiqgr elsdeevehl slkkyiidiv vestapaeal kdgeerqknk
      901 kkakkikarm nfrakeyesl metknsgsds pykaklqrla kdllkqvqvq dsgswannkv
      961 saldrtlgei trilekenva dqiafqaagg ltalehilqa vvpatnvntv lrippkslcn
     1021 ainvynltcn ncsencsdvl fsnkitflmd llihqltvyv pdenntilgr ntnkqvfegl
     1081 ttgllkvsav vlgclianrp dgncqpatpk iptqemknkp sqgdpfnnrv qdlirsysif
     1141 dnnrqdptgl taalqatdla gvlhmlycvl fhgtildpst aspkenytqn tiqvaiqslr
     1201 ffnsfaalhl pafqsivgae glslafrhma ssllghcsqv scesllhevi vcvgyftvnh
     1261 pdnqvivqsg rhptvlqklc qlpfqyfsdp rlikvlfpsl iaacynnhqn kiileqemsc
     1321 vllatfiqdl aqtpgqaenq pyqpkgkclg sqdylelanr fpqqaweear qfflkkekk
//
LOCUS       XP_047288581            1373 aa            linear   PRI 05-AUG-2025
DEFINITION  S phase cyclin A-associated protein in the endoplasmic reticulum
            isoform X6 [Homo sapiens].
ACCESSION   XP_047288581
VERSION     XP_047288581.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432625.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1373
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1373
                     /product="S phase cyclin A-associated protein in the
                     endoplasmic reticulum isoform X6"
                     /calculated_mol_wt=155184
     Region          114..211
                     /region_name="SCAPER_N"
                     /note="S phase cyclin A-associated protein in the
                     endoplasmic reticulum; pfam16501"
                     /db_xref="CDD:406813"
     Region          <370..736
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <562..>796
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          815..847
                     /region_name="ZnF_U1"
                     /note="U1-like zinc finger; smart00451"
                     /db_xref="CDD:197732"
     CDS             1..1373
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /coded_by="XM_047432625.1:87..4208"
                     /db_xref="GeneID:49855"
                     /db_xref="HGNC:HGNC:13081"
                     /db_xref="MIM:611611"
ORIGIN      
        1 mralrpggak slshlgvvgp sllpllllfs ktalpwrlss tpfsrshtpw vyvindlgie
       61 enlkndgkpk cqtggkskrt iqgthkttkq stavdckits sttgdkhfdk sptktrhprk
      121 idlrarywaf lfdnlrravd eiyvtcesdq svveckevlm mldnyvrdfk alidwiqlqe
      181 klektdaqsr ptslawevkk mspgrhvips pstdrinvts narrslnfgg stgtvpaprl
      241 aptgvswadk vkahhtgsta sseitpaqsc ppmtvqkasr knerkdaegw etvqrgrpir
      301 srstavmpkv slateatrsk ddsdkenvcl lpdesiqkgq fvgdgtsnti eshpkdslhs
      361 cdhplaektq ftvstlddvk nsgsirdnyv rtseisavhi dtecvsvmlq agtpplqvne
      421 ekfpaekari enemdpsdis nsmaevlakk eeladrleka neeaiasaia eeeqltreie
      481 aeenndinie tdndsdfsas mgsgsvsfcg msmdwndvla dyeareswrq ntswgdivee
      541 eparppghgi hmheklssps rkrtiaeskk kheekqmkaq qlreklreek tlklqkller
      601 ekdvrkwkee lldqrrrmme ekllhaefkr evqlqaivkk aqeeeakvne iafintleaq
      661 nkrhdvlskl keyeqrlnel qeerqrrqee kqardeavqe rkraleaerq arveellmkr
      721 keqearieqq rqekekared aarerardre erlaaltaaq qeameelqkk iqlkhdesir
      781 rhmeqieqrk ekaaelssgr hantdyapkl tpyerkkqcs lcnvlissev ylfshvkgrk
      841 hqqavrents iqgrelsdee vehlslkkyi idivvestap aealkdgeer qknkkkakki
      901 karmnfrake yeslmetkns gsdspykakl qrlakdllkq vqvqdsgswa nnkvsaldrt
      961 lgeitrilek envadqiafq aaggltaleh ilqavvpatn vntvlrippk slcnainvyn
     1021 ltcnncsenc sdvlfsnkit flmdllihql tvyvpdennt ilgrntnkqv feglttgllk
     1081 vsavvlgcli anrpdgncqp atpkiptqem knkpsqgdpf nnrvqdlirs ysifdnnrqd
     1141 ptgltaalqa tdlagvlhml ycvlfhgtil dpstaspken ytqntiqvai qslrffnsfa
     1201 alhlpafqsi vgaeglslaf rhmassllgh csqvscesll hevivcvgyf tvnhpdnqvi
     1261 vqsgrhptvl qklcqlpfqy fsdprlikvl fpsliaacyn nhqnkiileq emscvllatf
     1321 iqdlaqtpgq aenqpyqpkg kclgsqdyle lanrfpqqaw eearqfflkk ekk
//
LOCUS       XP_047288582            1348 aa            linear   PRI 05-AUG-2025
DEFINITION  S phase cyclin A-associated protein in the endoplasmic reticulum
            isoform X7 [Homo sapiens].
ACCESSION   XP_047288582
VERSION     XP_047288582.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432626.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1348
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1348
                     /product="S phase cyclin A-associated protein in the
                     endoplasmic reticulum isoform X7"
                     /calculated_mol_wt=152632
     Region          89..186
                     /region_name="SCAPER_N"
                     /note="S phase cyclin A-associated protein in the
                     endoplasmic reticulum; pfam16501"
                     /db_xref="CDD:406813"
     Region          <357..711
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <537..>771
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          790..822
                     /region_name="ZnF_U1"
                     /note="U1-like zinc finger; smart00451"
                     /db_xref="CDD:197732"
     CDS             1..1348
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /coded_by="XM_047432626.1:60..4106"
                     /db_xref="GeneID:49855"
                     /db_xref="HGNC:HGNC:13081"
                     /db_xref="MIM:611611"
ORIGIN      
        1 mmasfqrsns hdkvrrivae egrtarnlia wsvpleskdd dgkpkcqtgg kskrtiqgth
       61 kttkqstavd ckitssttgd khfdksptkt rhprkidlra rywaflfdnl rravdeiyvt
      121 cesdqsvvec kevlmmldny vrdfkalidw iqlqeklekt daqsrptsla wevkkmspgr
      181 hvipspstdr invtsnarrs lnfggstgtv paprlaptgv swadkvkahh tgstasseit
      241 paqscppmtv qkasrknerk daegwetvqr grpirsrsta vmpkvslate atrskddsdk
      301 envcllpdes iqkgqfvgdg tsntieshpk dslhscdhpl aektqftvst lddvknsgsi
      361 rdnyvrtsei savhidtecv svmlqagtpp lqvneekfpa ekarienemd psdisnsmae
      421 vlakkeelad rlekaneeai asaiaeeeql treieaeenn dinietdnds dfsasmgsgs
      481 vsfcgmsmdw ndvladyear eswrqntswg diveeeparp pghgihmhek lsspsrkrti
      541 aeskkkheek qmkaqqlrek lreektlklq kllerekdvr kwkeelldqr rrmmeekllh
      601 aefkrevqlq aivkkaqeee akvneiafin tleaqnkrhd vlsklkeyeq rlnelqeerq
      661 rrqeekqard eavqerkral eaerqarvee llmkrkeqea rieqqrqeke karedaarer
      721 ardreerlaa ltaaqqeame elqkkiqlkh desirrhmeq ieqrkekaae lssgrhantd
      781 yapkltpyer kkqcslcnvl issevylfsh vkgrkhqqav rentsiqgre lsdeevehls
      841 lkkyiidivv estapaealk dgeerqknkk kakkikarmn frakeyeslm etknsgsdsp
      901 ykaklqrlak dllkqvqvqd sgswannkvs aldrtlgeit rilekenvad qiafqaaggl
      961 talehilqav vpatnvntvl rippkslcna invynltcnn csencsdvlf snkitflmdl
     1021 lihqltvyvp denntilgrn tnkqvfeglt tgllkvsavv lgclianrpd gncqpatpki
     1081 ptqemknkps qgdpfnnrvq dlirsysifd nnrqdptglt aalqatdlag vlhmlycvlf
     1141 hgtildpsta spkenytqnt iqvaiqslrf fnsfaalhlp afqsivgaeg lslafrhmas
     1201 sllghcsqvs cesllheviv cvgyftvnhp dnqvivqsgr hptvlqklcq lpfqyfsdpr
     1261 likvlfpsli aacynnhqnk iileqemscv llatfiqdla qtpgqaenqp yqpkgkclgs
     1321 qdylelanrf pqqaweearq fflkkekk
//
LOCUS       XP_011519955            1272 aa            linear   PRI 05-AUG-2025
DEFINITION  S phase cyclin A-associated protein in the endoplasmic reticulum
            isoform X8 [Homo sapiens].
ACCESSION   XP_011519955
VERSION     XP_011519955.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521653.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1272
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1272
                     /product="S phase cyclin A-associated protein in the
                     endoplasmic reticulum isoform X8"
                     /calculated_mol_wt=143471
     Region          <1..52
                     /region_name="SCAPER_N"
                     /note="S phase cyclin A-associated protein in the
                     endoplasmic reticulum; pfam16501"
                     /db_xref="CDD:406813"
     Region          <211..583
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <409..>643
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          662..694
                     /region_name="ZnF_U1"
                     /note="U1-like zinc finger; smart00451"
                     /db_xref="CDD:197732"
     CDS             1..1272
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /coded_by="XM_011521653.4:386..4204"
                     /db_xref="GeneID:49855"
                     /db_xref="HGNC:HGNC:13081"
                     /db_xref="MIM:611611"
ORIGIN      
        1 mmldnyvrdf kalidwiqlq eklektdaqs rptslawevk kmspgrhvip spstdrinvt
       61 snarrslnfg gstgtvpapr laptgvswad kvkahhtgst asseitpaqs cppmtvqkas
      121 rknerkdaeg wetvqrgrpi rsrstavmpk vslateatrs kddsdkenvc llpdesiqkg
      181 qfvgdgtsnt ieshpkdslh scdhplaekt qftvstlddv knsgsirdny vrtseisavh
      241 idtecvsvml qagtpplqvn eekfpaekar ienemdpsdi snvsaanlsm aevlakkeel
      301 adrlekanee aiasaiaeee qltreieaee nndinietdn dsdfsasmgs gsvsfcgmsm
      361 dwndvladye areswrqnts wgdiveeepa rppghgihmh eklsspsrkr tiaeskkkhe
      421 ekqmkaqqlr eklreektlk lqkllerekd vrkwkeelld qrrrmmeekl lhaefkrevq
      481 lqaivkkaqe eeakvneiaf intleaqnkr hdvlsklkey eqrlnelqee rqrrqeekqa
      541 rdeavqerkr aleaerqarv eellmkrkeq earieqqrqe kekaredaar erardreerl
      601 aaltaaqqea meelqkkiql khdesirrhm eqieqrkeka aelssgrhan tdyapkltpy
      661 erkkqcslcn vlissevylf shvkgrkhqq avrentsiqg relsdeeveh lslkkyiidi
      721 vvestapaea lkdgeerqkn kkkakkikar mnfrakeyes lmetknsgsd spykaklqrl
      781 akdllkqvqv qdsgswannk vsaldrtlge itrilekenv adqiafqaag gltalehilq
      841 avvpatnvnt vlrippkslc nainvynltc nncsencsdv lfsnkitflm dllihqltvy
      901 vpdenntilg rntnkqvfeg lttgllkvsa vvlgclianr pdgncqpatp kiptqemknk
      961 psqgdpfnnr vqdlisyvvn mglidklcac flsvqgpvde npkmaiflqh aagllhamct
     1021 lcfavtgrsy sifdnnrqdp tgltaalqat dlagvlhmly cvlfhgtild pstaspkeny
     1081 tqntiqvaiq slrffnsfaa lhlpafqsiv gaeglslafr hmassllghc sqvscesllh
     1141 evivcvgyft vnhpdnqviv qsgrhptvlq klcqlpfqyf sdprlikvlf psliaacynn
     1201 hqnkiileqe mscvllatfi qdlaqtpgqa enqpyqpkgk clgsqdylel anrfpqqawe
     1261 earqfflkke kk
//
LOCUS       XP_016877762            1266 aa            linear   PRI 05-AUG-2025
DEFINITION  S phase cyclin A-associated protein in the endoplasmic reticulum
            isoform X9 [Homo sapiens].
ACCESSION   XP_016877762
VERSION     XP_016877762.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022273.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1266
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1266
                     /product="S phase cyclin A-associated protein in the
                     endoplasmic reticulum isoform X9"
                     /calculated_mol_wt=142916
     Region          <1..52
                     /region_name="SCAPER_N"
                     /note="S phase cyclin A-associated protein in the
                     endoplasmic reticulum; pfam16501"
                     /db_xref="CDD:406813"
     Region          <211..577
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <403..>637
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          656..688
                     /region_name="ZnF_U1"
                     /note="U1-like zinc finger; smart00451"
                     /db_xref="CDD:197732"
     CDS             1..1266
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /coded_by="XM_017022273.2:386..4186"
                     /db_xref="GeneID:49855"
                     /db_xref="HGNC:HGNC:13081"
                     /db_xref="MIM:611611"
ORIGIN      
        1 mmldnyvrdf kalidwiqlq eklektdaqs rptslawevk kmspgrhvip spstdrinvt
       61 snarrslnfg gstgtvpapr laptgvswad kvkahhtgst asseitpaqs cppmtvqkas
      121 rknerkdaeg wetvqrgrpi rsrstavmpk vslateatrs kddsdkenvc llpdesiqkg
      181 qfvgdgtsnt ieshpkdslh scdhplaekt qftvstlddv knsgsirdny vrtseisavh
      241 idtecvsvml qagtpplqvn eekfpaekar ienemdpsdi snsmaevlak keeladrlek
      301 aneeaiasai aeeeqltrei eaeenndini etdndsdfsa smgsgsvsfc gmsmdwndvl
      361 adyeareswr qntswgdive eeparppghg ihmheklssp srkrtiaesk kkheekqmka
      421 qqlreklree ktlklqklle rekdvrkwke elldqrrrmm eekllhaefk revqlqaivk
      481 kaqeeeakvn eiafintlea qnkrhdvlsk lkeyeqrlne lqeerqrrqe ekqardeavq
      541 erkraleaer qarveellmk rkeqearieq qrqekekare daarerardr eerlaaltaa
      601 qqeameelqk kiqlkhdesi rrhmeqieqr kekaaelssg rhantdyapk ltpyerkkqc
      661 slcnvlisse vylfshvkgr khqqavrent siqgrelsde evehlslkky iidivvesta
      721 paealkdgee rqknkkkakk ikarmnfrak eyeslmetkn sgsdspykak lqrlakdllk
      781 qvqvqdsgsw annkvsaldr tlgeitrile kenvadqiaf qaaggltale hilqavvpat
      841 nvntvlripp kslcnainvy nltcnncsen csdvlfsnki tflmdllihq ltvyvpdenn
      901 tilgrntnkq vfeglttgll kvsavvlgcl ianrpdgncq patpkiptqe mknkpsqgdp
      961 fnnrvqdlis yvvnmglidk lcacflsvqg pvdenpkmai flqhaagllh amctlcfavt
     1021 grsysifdnn rqdptgltaa lqatdlagvl hmlycvlfhg tildpstasp kenytqntiq
     1081 vaiqslrffn sfaalhlpaf qsivgaegls lafrhmassl lghcsqvsce sllhevivcv
     1141 gyftvnhpdn qvivqsgrhp tvlqklcqlp fqyfsdprli kvlfpsliaa cynnhqnkii
     1201 leqemscvll atfiqdlaqt pgqaenqpyq pkgkclgsqd ylelanrfpq qaweearqff
     1261 lkkekk
//
LOCUS       XP_047288583            1160 aa            linear   PRI 05-AUG-2025
DEFINITION  S phase cyclin A-associated protein in the endoplasmic reticulum
            isoform X10 [Homo sapiens].
ACCESSION   XP_047288583
VERSION     XP_047288583.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432627.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1160
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1160
                     /product="S phase cyclin A-associated protein in the
                     endoplasmic reticulum isoform X10"
                     /calculated_mol_wt=131361
     Region          <111..471
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <297..>531
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          550..582
                     /region_name="ZnF_U1"
                     /note="U1-like zinc finger; smart00451"
                     /db_xref="CDD:197732"
     CDS             1..1160
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /coded_by="XM_047432627.1:97..3579"
                     /db_xref="GeneID:49855"
                     /db_xref="HGNC:HGNC:13081"
                     /db_xref="MIM:611611"
ORIGIN      
        1 mktkyifcni terkdaegwe tvqrgrpirs rstavmpkvs lateatrskd dsdkenvcll
       61 pdesiqkgqf vgdgtsntie shpkdslhsc dhplaektqf tvstlddvkn sgsirdnyvr
      121 tseisavhid tecvsvmlqa gtpplqvnee kfpaekarie nemdpsdisn vsaanlsmae
      181 vlakkeelad rlekaneeai asaiaeeeql treieaeenn dinietdnds dfsasmgsgs
      241 vsfcgmsmdw ndvladyear eswrqntswg diveeeparp pghgihmhek lsspsrkrti
      301 aeskkkheek qmkaqqlrek lreektlklq kllerekdvr kwkeelldqr rrmmeekllh
      361 aefkrevqlq aivkkaqeee akvneiafin tleaqnkrhd vlsklkeyeq rlnelqeerq
      421 rrqeekqard eavqerkral eaerqarvee llmkrkeqea rieqqrqeke karedaarer
      481 ardreerlaa ltaaqqeame elqkkiqlkh desirrhmeq ieqrkekaae lssgrhantd
      541 yapkltpyer kkqcslcnvl issevylfsh vkgrkhqqav rentsiqgre lsdeevehls
      601 lkkyiidivv estapaealk dgeerqknkk kakkikarmn frakeyeslm etknsgsdsp
      661 ykaklqrlak dllkqvqvqd sgswannkvs aldrtlgeit rilekenvad qiafqaaggl
      721 talehilqav vpatnvntvl rippkslcna invynltcnn csencsdvlf snkitflmdl
      781 lihqltvyvp denntilgrn tnkqvfeglt tgllkvsavv lgclianrpd gncqpatpki
      841 ptqemknkps qgdpfnnrvq dlisyvvnmg lidklcacfl svqgpvdenp kmaiflqhaa
      901 gllhamctlc favtgrsysi fdnnrqdptg ltaalqatdl agvlhmlycv lfhgtildps
      961 taspkenytq ntiqvaiqsl rffnsfaalh lpafqsivga eglslafrhm assllghcsq
     1021 vscesllhev ivcvgyftvn hpdnqvivqs grhptvlqkl cqlpfqyfsd prlikvlfps
     1081 liaacynnhq nkiileqems cvllatfiqd laqtpgqaen qpyqpkgkcl gsqdylelan
     1141 rfpqqaweea rqfflkkekk
//
LOCUS       XP_024305708            1066 aa            linear   PRI 05-AUG-2025
DEFINITION  S phase cyclin A-associated protein in the endoplasmic reticulum
            isoform X11 [Homo sapiens].
ACCESSION   XP_024305708
VERSION     XP_024305708.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449940.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XP_024305708.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1066
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1066
                     /product="S phase cyclin A-associated protein in the
                     endoplasmic reticulum isoform X11"
                     /calculated_mol_wt=120978
     Region          114..211
                     /region_name="SCAPER_N"
                     /note="S phase cyclin A-associated protein in the
                     endoplasmic reticulum; pfam16501"
                     /db_xref="CDD:406813"
     Region          <382..739
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <568..>802
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          821..853
                     /region_name="ZnF_U1"
                     /note="U1-like zinc finger; smart00451"
                     /db_xref="CDD:197732"
     CDS             1..1066
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /coded_by="XM_024449940.2:87..3287"
                     /db_xref="GeneID:49855"
                     /db_xref="HGNC:HGNC:13081"
                     /db_xref="MIM:611611"
ORIGIN      
        1 mralrpggak slshlgvvgp sllpllllfs ktalpwrlss tpfsrshtpw vyvindlgie
       61 enlkndgkpk cqtggkskrt iqgthkttkq stavdckits sttgdkhfdk sptktrhprk
      121 idlrarywaf lfdnlrravd eiyvtcesdq svveckevlm mldnyvrdfk alidwiqlqe
      181 klektdaqsr ptslawevkk mspgrhvips pstdrinvts narrslnfgg stgtvpaprl
      241 aptgvswadk vkahhtgsta sseitpaqsc ppmtvqkasr knerkdaegw etvqrgrpir
      301 srstavmpkv slateatrsk ddsdkenvcl lpdesiqkgq fvgdgtsnti eshpkdslhs
      361 cdhplaektq ftvstlddvk nsgsirdnyv rtseisavhi dtecvsvmlq agtpplqvne
      421 ekfpaekari enemdpsdis nvsaanlsma evlakkeela drlekaneea iasaiaeeeq
      481 ltreieaeen ndinietdnd sdfsasmgsg svsfcgmsmd wndvladyea reswrqntsw
      541 gdiveeepar ppghgihmhe klsspsrkrt iaeskkkhee kqmkaqqlre klreektlkl
      601 qkllerekdv rkwkeelldq rrrmmeekll haefkrevql qaivkkaqee eakvneiafi
      661 ntleaqnkrh dvlsklkeye qrlnelqeer qrrqeekqar deavqerkra leaerqarve
      721 ellmkrkeqe arieqqrqek ekaredaare rardreerla altaaqqeam eelqkkiqlk
      781 hdesirrhme qieqrkekaa elssgrhant dyapkltpye rkkqcslcnv lissevylfs
      841 hvkgrkhqqa vrentsiqgr elsdeevehl slkkyiidiv vestapaeal kdgeerqknk
      901 kkakkikarm nfrakeyesl metknsgsds pykaklqrla kdllkqvqvq dsgswannkv
      961 saldrtlgei trilekenva dqiafqaagg ltalehilqa vvpatnvntv lrippkslcn
     1021 ainvynltcn ncsencsdvl fsnkitflmd llihqltmrk lesqrg
//
LOCUS       XP_024305709            1066 aa            linear   PRI 05-AUG-2025
DEFINITION  S phase cyclin A-associated protein in the endoplasmic reticulum
            isoform X12 [Homo sapiens].
ACCESSION   XP_024305709
VERSION     XP_024305709.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449941.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XP_024305709.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1066
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1066
                     /product="S phase cyclin A-associated protein in the
                     endoplasmic reticulum isoform X12"
                     /calculated_mol_wt=120970
     Region          114..211
                     /region_name="SCAPER_N"
                     /note="S phase cyclin A-associated protein in the
                     endoplasmic reticulum; pfam16501"
                     /db_xref="CDD:406813"
     Region          <382..739
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <568..>802
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          821..853
                     /region_name="ZnF_U1"
                     /note="U1-like zinc finger; smart00451"
                     /db_xref="CDD:197732"
     CDS             1..1066
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /coded_by="XM_024449941.2:87..3287"
                     /db_xref="GeneID:49855"
                     /db_xref="HGNC:HGNC:13081"
                     /db_xref="MIM:611611"
ORIGIN      
        1 mralrpggak slshlgvvgp sllpllllfs ktalpwrlss tpfsrshtpw vyvindlgie
       61 enlkndgkpk cqtggkskrt iqgthkttkq stavdckits sttgdkhfdk sptktrhprk
      121 idlrarywaf lfdnlrravd eiyvtcesdq svveckevlm mldnyvrdfk alidwiqlqe
      181 klektdaqsr ptslawevkk mspgrhvips pstdrinvts narrslnfgg stgtvpaprl
      241 aptgvswadk vkahhtgsta sseitpaqsc ppmtvqkasr knerkdaegw etvqrgrpir
      301 srstavmpkv slateatrsk ddsdkenvcl lpdesiqkgq fvgdgtsnti eshpkdslhs
      361 cdhplaektq ftvstlddvk nsgsirdnyv rtseisavhi dtecvsvmlq agtpplqvne
      421 ekfpaekari enemdpsdis nvsaanlsma evlakkeela drlekaneea iasaiaeeeq
      481 ltreieaeen ndinietdnd sdfsasmgsg svsfcgmsmd wndvladyea reswrqntsw
      541 gdiveeepar ppghgihmhe klsspsrkrt iaeskkkhee kqmkaqqlre klreektlkl
      601 qkllerekdv rkwkeelldq rrrmmeekll haefkrevql qaivkkaqee eakvneiafi
      661 ntleaqnkrh dvlsklkeye qrlnelqeer qrrqeekqar deavqerkra leaerqarve
      721 ellmkrkeqe arieqqrqek ekaredaare rardreerla altaaqqeam eelqkkiqlk
      781 hdesirrhme qieqrkekaa elssgrhant dyapkltpye rkkqcslcnv lissevylfs
      841 hvkgrkhqqa vrentsiqgr elsdeevehl slkkyiidiv vestapaeal kdgeerqknk
      901 kkakkikarm nfrakeyesl metknsgsds pykaklqrla kdllkqvqvq dsgswannkv
      961 saldrtlgei trilekenva dqiafqaagg ltalehilqa vvpatnvntv lrippkslcn
     1021 ainvynltcn ncsencsdvl fsnkitflmd llihqltqrp edsdhl
//
LOCUS       XP_024305710            1065 aa            linear   PRI 05-AUG-2025
DEFINITION  S phase cyclin A-associated protein in the endoplasmic reticulum
            isoform X13 [Homo sapiens].
ACCESSION   XP_024305710
VERSION     XP_024305710.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449942.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XP_024305710.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1065
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1065
                     /product="S phase cyclin A-associated protein in the
                     endoplasmic reticulum isoform X13"
                     /calculated_mol_wt=120842
     Region          114..211
                     /region_name="SCAPER_N"
                     /note="S phase cyclin A-associated protein in the
                     endoplasmic reticulum; pfam16501"
                     /db_xref="CDD:406813"
     Region          <382..739
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <568..>802
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          821..853
                     /region_name="ZnF_U1"
                     /note="U1-like zinc finger; smart00451"
                     /db_xref="CDD:197732"
     CDS             1..1065
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /coded_by="XM_024449942.2:87..3284"
                     /db_xref="GeneID:49855"
                     /db_xref="HGNC:HGNC:13081"
                     /db_xref="MIM:611611"
ORIGIN      
        1 mralrpggak slshlgvvgp sllpllllfs ktalpwrlss tpfsrshtpw vyvindlgie
       61 enlkndgkpk cqtggkskrt iqgthkttkq stavdckits sttgdkhfdk sptktrhprk
      121 idlrarywaf lfdnlrravd eiyvtcesdq svveckevlm mldnyvrdfk alidwiqlqe
      181 klektdaqsr ptslawevkk mspgrhvips pstdrinvts narrslnfgg stgtvpaprl
      241 aptgvswadk vkahhtgsta sseitpaqsc ppmtvqkasr knerkdaegw etvqrgrpir
      301 srstavmpkv slateatrsk ddsdkenvcl lpdesiqkgq fvgdgtsnti eshpkdslhs
      361 cdhplaektq ftvstlddvk nsgsirdnyv rtseisavhi dtecvsvmlq agtpplqvne
      421 ekfpaekari enemdpsdis nvsaanlsma evlakkeela drlekaneea iasaiaeeeq
      481 ltreieaeen ndinietdnd sdfsasmgsg svsfcgmsmd wndvladyea reswrqntsw
      541 gdiveeepar ppghgihmhe klsspsrkrt iaeskkkhee kqmkaqqlre klreektlkl
      601 qkllerekdv rkwkeelldq rrrmmeekll haefkrevql qaivkkaqee eakvneiafi
      661 ntleaqnkrh dvlsklkeye qrlnelqeer qrrqeekqar deavqerkra leaerqarve
      721 ellmkrkeqe arieqqrqek ekaredaare rardreerla altaaqqeam eelqkkiqlk
      781 hdesirrhme qieqrkekaa elssgrhant dyapkltpye rkkqcslcnv lissevylfs
      841 hvkgrkhqqa vrentsiqgr elsdeevehl slkkyiidiv vestapaeal kdgeerqknk
      901 kkakkikarm nfrakeyesl metknsgsds pykaklqrla kdllkqvqvq dsgswannkv
      961 saldrtlgei trilekenva dqiafqaagg ltalehilqa vvpatnvntv lrippkslcn
     1021 ainvynltcn ncsencsdvl fsnkitflmd llihqltrpe dsdhl
//
LOCUS       XP_047288584            1060 aa            linear   PRI 05-AUG-2025
DEFINITION  S phase cyclin A-associated protein in the endoplasmic reticulum
            isoform X14 [Homo sapiens].
ACCESSION   XP_047288584
VERSION     XP_047288584.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432628.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1060
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1060
                     /product="S phase cyclin A-associated protein in the
                     endoplasmic reticulum isoform X14"
                     /calculated_mol_wt=120414
     Region          114..211
                     /region_name="SCAPER_N"
                     /note="S phase cyclin A-associated protein in the
                     endoplasmic reticulum; pfam16501"
                     /db_xref="CDD:406813"
     Region          <382..733
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <562..>796
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          815..847
                     /region_name="ZnF_U1"
                     /note="U1-like zinc finger; smart00451"
                     /db_xref="CDD:197732"
     CDS             1..1060
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /coded_by="XM_047432628.1:87..3269"
                     /db_xref="GeneID:49855"
                     /db_xref="HGNC:HGNC:13081"
                     /db_xref="MIM:611611"
ORIGIN      
        1 mralrpggak slshlgvvgp sllpllllfs ktalpwrlss tpfsrshtpw vyvindlgie
       61 enlkndgkpk cqtggkskrt iqgthkttkq stavdckits sttgdkhfdk sptktrhprk
      121 idlrarywaf lfdnlrravd eiyvtcesdq svveckevlm mldnyvrdfk alidwiqlqe
      181 klektdaqsr ptslawevkk mspgrhvips pstdrinvts narrslnfgg stgtvpaprl
      241 aptgvswadk vkahhtgsta sseitpaqsc ppmtvqkasr knerkdaegw etvqrgrpir
      301 srstavmpkv slateatrsk ddsdkenvcl lpdesiqkgq fvgdgtsnti eshpkdslhs
      361 cdhplaektq ftvstlddvk nsgsirdnyv rtseisavhi dtecvsvmlq agtpplqvne
      421 ekfpaekari enemdpsdis nsmaevlakk eeladrleka neeaiasaia eeeqltreie
      481 aeenndinie tdndsdfsas mgsgsvsfcg msmdwndvla dyeareswrq ntswgdivee
      541 eparppghgi hmheklssps rkrtiaeskk kheekqmkaq qlreklreek tlklqkller
      601 ekdvrkwkee lldqrrrmme ekllhaefkr evqlqaivkk aqeeeakvne iafintleaq
      661 nkrhdvlskl keyeqrlnel qeerqrrqee kqardeavqe rkraleaerq arveellmkr
      721 keqearieqq rqekekared aarerardre erlaaltaaq qeameelqkk iqlkhdesir
      781 rhmeqieqrk ekaaelssgr hantdyapkl tpyerkkqcs lcnvlissev ylfshvkgrk
      841 hqqavrents iqgrelsdee vehlslkkyi idivvestap aealkdgeer qknkkkakki
      901 karmnfrake yeslmetkns gsdspykakl qrlakdllkq vqvqdsgswa nnkvsaldrt
      961 lgeitrilek envadqiafq aaggltaleh ilqavvpatn vntvlrippk slcnainvyn
     1021 ltcnncsenc sdvlfsnkit flmdllihql tqrpedsdhl
//
LOCUS       XP_047288585            1058 aa            linear   PRI 05-AUG-2025
DEFINITION  S phase cyclin A-associated protein in the endoplasmic reticulum
            isoform X15 [Homo sapiens].
ACCESSION   XP_047288585
VERSION     XP_047288585.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432629.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1058
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1058
                     /product="S phase cyclin A-associated protein in the
                     endoplasmic reticulum isoform X15"
                     /calculated_mol_wt=120006
     Region          114..211
                     /region_name="SCAPER_N"
                     /note="S phase cyclin A-associated protein in the
                     endoplasmic reticulum; pfam16501"
                     /db_xref="CDD:406813"
     Region          <382..739
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <568..>802
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          821..853
                     /region_name="ZnF_U1"
                     /note="U1-like zinc finger; smart00451"
                     /db_xref="CDD:197732"
     CDS             1..1058
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /coded_by="XM_047432629.1:87..3263"
                     /db_xref="GeneID:49855"
                     /db_xref="HGNC:HGNC:13081"
                     /db_xref="MIM:611611"
ORIGIN      
        1 mralrpggak slshlgvvgp sllpllllfs ktalpwrlss tpfsrshtpw vyvindlgie
       61 enlkndgkpk cqtggkskrt iqgthkttkq stavdckits sttgdkhfdk sptktrhprk
      121 idlrarywaf lfdnlrravd eiyvtcesdq svveckevlm mldnyvrdfk alidwiqlqe
      181 klektdaqsr ptslawevkk mspgrhvips pstdrinvts narrslnfgg stgtvpaprl
      241 aptgvswadk vkahhtgsta sseitpaqsc ppmtvqkasr knerkdaegw etvqrgrpir
      301 srstavmpkv slateatrsk ddsdkenvcl lpdesiqkgq fvgdgtsnti eshpkdslhs
      361 cdhplaektq ftvstlddvk nsgsirdnyv rtseisavhi dtecvsvmlq agtpplqvne
      421 ekfpaekari enemdpsdis nvsaanlsma evlakkeela drlekaneea iasaiaeeeq
      481 ltreieaeen ndinietdnd sdfsasmgsg svsfcgmsmd wndvladyea reswrqntsw
      541 gdiveeepar ppghgihmhe klsspsrkrt iaeskkkhee kqmkaqqlre klreektlkl
      601 qkllerekdv rkwkeelldq rrrmmeekll haefkrevql qaivkkaqee eakvneiafi
      661 ntleaqnkrh dvlsklkeye qrlnelqeer qrrqeekqar deavqerkra leaerqarve
      721 ellmkrkeqe arieqqrqek ekaredaare rardreerla altaaqqeam eelqkkiqlk
      781 hdesirrhme qieqrkekaa elssgrhant dyapkltpye rkkqcslcnv lissevylfs
      841 hvkgrkhqqa vrentsiqgr elsdeevehl slkkyiidiv vestapaeal kdgeerqknk
      901 kkakkikarm nfrakeyesl metknsgsds pykaklqrla kdllkqvqvq dsgswannkv
      961 saldrtlgei trilekenva dqiafqaagg ltalehilqa vvpatnvntv lrippkslcn
     1021 ainvynltcn ncsencsdvl fsnkitflmd llihqltn
//
LOCUS       XP_047288586            1009 aa            linear   PRI 05-AUG-2025
DEFINITION  S phase cyclin A-associated protein in the endoplasmic reticulum
            isoform X16 [Homo sapiens].
ACCESSION   XP_047288586
VERSION     XP_047288586.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432630.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1009
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1009
                     /product="S phase cyclin A-associated protein in the
                     endoplasmic reticulum isoform X16"
                     /calculated_mol_wt=114949
     Region          114..211
                     /region_name="SCAPER_N"
                     /note="S phase cyclin A-associated protein in the
                     endoplasmic reticulum; pfam16501"
                     /db_xref="CDD:406813"
     Region          <382..739
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <568..>802
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          821..853
                     /region_name="ZnF_U1"
                     /note="U1-like zinc finger; smart00451"
                     /db_xref="CDD:197732"
     CDS             1..1009
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /coded_by="XM_047432630.1:87..3116"
                     /db_xref="GeneID:49855"
                     /db_xref="HGNC:HGNC:13081"
                     /db_xref="MIM:611611"
ORIGIN      
        1 mralrpggak slshlgvvgp sllpllllfs ktalpwrlss tpfsrshtpw vyvindlgie
       61 enlkndgkpk cqtggkskrt iqgthkttkq stavdckits sttgdkhfdk sptktrhprk
      121 idlrarywaf lfdnlrravd eiyvtcesdq svveckevlm mldnyvrdfk alidwiqlqe
      181 klektdaqsr ptslawevkk mspgrhvips pstdrinvts narrslnfgg stgtvpaprl
      241 aptgvswadk vkahhtgsta sseitpaqsc ppmtvqkasr knerkdaegw etvqrgrpir
      301 srstavmpkv slateatrsk ddsdkenvcl lpdesiqkgq fvgdgtsnti eshpkdslhs
      361 cdhplaektq ftvstlddvk nsgsirdnyv rtseisavhi dtecvsvmlq agtpplqvne
      421 ekfpaekari enemdpsdis nvsaanlsma evlakkeela drlekaneea iasaiaeeeq
      481 ltreieaeen ndinietdnd sdfsasmgsg svsfcgmsmd wndvladyea reswrqntsw
      541 gdiveeepar ppghgihmhe klsspsrkrt iaeskkkhee kqmkaqqlre klreektlkl
      601 qkllerekdv rkwkeelldq rrrmmeekll haefkrevql qaivkkaqee eakvneiafi
      661 ntleaqnkrh dvlsklkeye qrlnelqeer qrrqeekqar deavqerkra leaerqarve
      721 ellmkrkeqe arieqqrqek ekaredaare rardreerla altaaqqeam eelqkkiqlk
      781 hdesirrhme qieqrkekaa elssgrhant dyapkltpye rkkqcslcnv lissevylfs
      841 hvkgrkhqqa vrentsiqgr elsdeevehl slkkyiidiv vestapaeal kdgeerqknk
      901 kkakkikarm nfrakeyesl metknsgsds pykaklqrla kdllkqvqvq dsgswannkv
      961 saldrtlgei trilekevyt vwkamhistr qdihkcsmaa lfiittygk
//
LOCUS       XP_024305712             892 aa            linear   PRI 05-AUG-2025
DEFINITION  S phase cyclin A-associated protein in the endoplasmic reticulum
            isoform X17 [Homo sapiens].
ACCESSION   XP_024305712
VERSION     XP_024305712.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449944.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XP_024305712.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..892
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..892
                     /product="S phase cyclin A-associated protein in the
                     endoplasmic reticulum isoform X17"
                     /calculated_mol_wt=101767
     Region          114..211
                     /region_name="SCAPER_N"
                     /note="S phase cyclin A-associated protein in the
                     endoplasmic reticulum; pfam16501"
                     /db_xref="CDD:406813"
     Region          <382..739
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <568..>802
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          821..853
                     /region_name="ZnF_U1"
                     /note="U1-like zinc finger; smart00451"
                     /db_xref="CDD:197732"
     CDS             1..892
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /coded_by="XM_024449944.2:87..2765"
                     /db_xref="GeneID:49855"
                     /db_xref="HGNC:HGNC:13081"
                     /db_xref="MIM:611611"
ORIGIN      
        1 mralrpggak slshlgvvgp sllpllllfs ktalpwrlss tpfsrshtpw vyvindlgie
       61 enlkndgkpk cqtggkskrt iqgthkttkq stavdckits sttgdkhfdk sptktrhprk
      121 idlrarywaf lfdnlrravd eiyvtcesdq svveckevlm mldnyvrdfk alidwiqlqe
      181 klektdaqsr ptslawevkk mspgrhvips pstdrinvts narrslnfgg stgtvpaprl
      241 aptgvswadk vkahhtgsta sseitpaqsc ppmtvqkasr knerkdaegw etvqrgrpir
      301 srstavmpkv slateatrsk ddsdkenvcl lpdesiqkgq fvgdgtsnti eshpkdslhs
      361 cdhplaektq ftvstlddvk nsgsirdnyv rtseisavhi dtecvsvmlq agtpplqvne
      421 ekfpaekari enemdpsdis nvsaanlsma evlakkeela drlekaneea iasaiaeeeq
      481 ltreieaeen ndinietdnd sdfsasmgsg svsfcgmsmd wndvladyea reswrqntsw
      541 gdiveeepar ppghgihmhe klsspsrkrt iaeskkkhee kqmkaqqlre klreektlkl
      601 qkllerekdv rkwkeelldq rrrmmeekll haefkrevql qaivkkaqee eakvneiafi
      661 ntleaqnkrh dvlsklkeye qrlnelqeer qrrqeekqar deavqerkra leaerqarve
      721 ellmkrkeqe arieqqrqek ekaredaare rardreerla altaaqqeam eelqkkiqlk
      781 hdesirrhme qieqrkekaa elssgrhant dyapkltpye rkkqcslcnv lissevylfs
      841 hvkgrkhqqa vrentsiqgr elsdeevvwh slvksinlky iadeflhmyk li
//
LOCUS       XP_047288587             886 aa            linear   PRI 05-AUG-2025
DEFINITION  S phase cyclin A-associated protein in the endoplasmic reticulum
            isoform X18 [Homo sapiens].
ACCESSION   XP_047288587
VERSION     XP_047288587.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432631.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..886
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..886
                     /product="S phase cyclin A-associated protein in the
                     endoplasmic reticulum isoform X18"
                     /calculated_mol_wt=101211
     Region          114..211
                     /region_name="SCAPER_N"
                     /note="S phase cyclin A-associated protein in the
                     endoplasmic reticulum; pfam16501"
                     /db_xref="CDD:406813"
     Region          <382..733
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <562..>796
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          815..847
                     /region_name="ZnF_U1"
                     /note="U1-like zinc finger; smart00451"
                     /db_xref="CDD:197732"
     CDS             1..886
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /coded_by="XM_047432631.1:87..2747"
                     /db_xref="GeneID:49855"
                     /db_xref="HGNC:HGNC:13081"
                     /db_xref="MIM:611611"
ORIGIN      
        1 mralrpggak slshlgvvgp sllpllllfs ktalpwrlss tpfsrshtpw vyvindlgie
       61 enlkndgkpk cqtggkskrt iqgthkttkq stavdckits sttgdkhfdk sptktrhprk
      121 idlrarywaf lfdnlrravd eiyvtcesdq svveckevlm mldnyvrdfk alidwiqlqe
      181 klektdaqsr ptslawevkk mspgrhvips pstdrinvts narrslnfgg stgtvpaprl
      241 aptgvswadk vkahhtgsta sseitpaqsc ppmtvqkasr knerkdaegw etvqrgrpir
      301 srstavmpkv slateatrsk ddsdkenvcl lpdesiqkgq fvgdgtsnti eshpkdslhs
      361 cdhplaektq ftvstlddvk nsgsirdnyv rtseisavhi dtecvsvmlq agtpplqvne
      421 ekfpaekari enemdpsdis nsmaevlakk eeladrleka neeaiasaia eeeqltreie
      481 aeenndinie tdndsdfsas mgsgsvsfcg msmdwndvla dyeareswrq ntswgdivee
      541 eparppghgi hmheklssps rkrtiaeskk kheekqmkaq qlreklreek tlklqkller
      601 ekdvrkwkee lldqrrrmme ekllhaefkr evqlqaivkk aqeeeakvne iafintleaq
      661 nkrhdvlskl keyeqrlnel qeerqrrqee kqardeavqe rkraleaerq arveellmkr
      721 keqearieqq rqekekared aarerardre erlaaltaaq qeameelqkk iqlkhdesir
      781 rhmeqieqrk ekaaelssgr hantdyapkl tpyerkkqcs lcnvlissev ylfshvkgrk
      841 hqqavrents iqgrelsdee vvwhslvksi nlkyiadefl hmykli
//
LOCUS       XP_016877772             861 aa            linear   PRI 05-AUG-2025
DEFINITION  S phase cyclin A-associated protein in the endoplasmic reticulum
            isoform X19 [Homo sapiens].
ACCESSION   XP_016877772
VERSION     XP_016877772.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022283.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..861
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..861
                     /product="S phase cyclin A-associated protein in the
                     endoplasmic reticulum isoform X19"
                     /calculated_mol_wt=98660
     Region          89..186
                     /region_name="SCAPER_N"
                     /note="S phase cyclin A-associated protein in the
                     endoplasmic reticulum; pfam16501"
                     /db_xref="CDD:406813"
     Region          <357..708
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <537..>771
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          790..822
                     /region_name="ZnF_U1"
                     /note="U1-like zinc finger; smart00451"
                     /db_xref="CDD:197732"
     CDS             1..861
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /coded_by="XM_017022283.2:60..2645"
                     /db_xref="GeneID:49855"
                     /db_xref="HGNC:HGNC:13081"
                     /db_xref="MIM:611611"
ORIGIN      
        1 mmasfqrsns hdkvrrivae egrtarnlia wsvpleskdd dgkpkcqtgg kskrtiqgth
       61 kttkqstavd ckitssttgd khfdksptkt rhprkidlra rywaflfdnl rravdeiyvt
      121 cesdqsvvec kevlmmldny vrdfkalidw iqlqeklekt daqsrptsla wevkkmspgr
      181 hvipspstdr invtsnarrs lnfggstgtv paprlaptgv swadkvkahh tgstasseit
      241 paqscppmtv qkasrknerk daegwetvqr grpirsrsta vmpkvslate atrskddsdk
      301 envcllpdes iqkgqfvgdg tsntieshpk dslhscdhpl aektqftvst lddvknsgsi
      361 rdnyvrtsei savhidtecv svmlqagtpp lqvneekfpa ekarienemd psdisnsmae
      421 vlakkeelad rlekaneeai asaiaeeeql treieaeenn dinietdnds dfsasmgsgs
      481 vsfcgmsmdw ndvladyear eswrqntswg diveeeparp pghgihmhek lsspsrkrti
      541 aeskkkheek qmkaqqlrek lreektlklq kllerekdvr kwkeelldqr rrmmeekllh
      601 aefkrevqlq aivkkaqeee akvneiafin tleaqnkrhd vlsklkeyeq rlnelqeerq
      661 rrqeekqard eavqerkral eaerqarvee llmkrkeqea rieqqrqeke karedaarer
      721 ardreerlaa ltaaqqeame elqkkiqlkh desirrhmeq ieqrkekaae lssgrhantd
      781 yapkltpyer kkqcslcnvl issevylfsh vkgrkhqqav rentsiqgre lsdeevvwhs
      841 lvksinlkyi adeflhmykl i
//
LOCUS       XP_011519958             786 aa            linear   PRI 05-AUG-2025
DEFINITION  S phase cyclin A-associated protein in the endoplasmic reticulum
            isoform X20 [Homo sapiens].
ACCESSION   XP_011519958
VERSION     XP_011519958.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521656.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..786
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..786
                     /product="S phase cyclin A-associated protein in the
                     endoplasmic reticulum isoform X20"
                     /calculated_mol_wt=88860
     Region          <19..>156
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          176..208
                     /region_name="ZnF_U1"
                     /note="U1-like zinc finger; smart00451"
                     /db_xref="CDD:197732"
     CDS             1..786
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /coded_by="XM_011521656.4:87..2447"
                     /db_xref="GeneID:49855"
                     /db_xref="HGNC:HGNC:13081"
                     /db_xref="MIM:611611"
ORIGIN      
        1 mlrllksvvn eiafintlea qnkrhdvlsk lkeyeqrlne lqeerqrrqe ekqardeavq
       61 erkraleaer qarveellmk rkeqearieq qrqekekare daarerardr eerlaaltaa
      121 qqeameelqk kiqlkhdesi rrhmeqieqr kekaaelssg rhantdyapk ltpyerkkqc
      181 slcnvlisse vylfshvkgr khqqavrent siqgrelsde evehlslkky iidivvesta
      241 paealkdgee rqknkkkakk ikarmnfrak eyeslmetkn sgsdspykak lqrlakdllk
      301 qvqvqdsgsw annkvsaldr tlgeitrile kenvadqiaf qaaggltale hilqavvpat
      361 nvntvlripp kslcnainvy nltcnncsen csdvlfsnki tflmdllihq ltvyvpdenn
      421 tilgrntnkq vfeglttgll kvsavvlgcl ianrpdgncq patpkiptqe mknkpsqgdp
      481 fnnrvqdlis yvvnmglidk lcacflsvqg pvdenpkmai flqhaagllh amctlcfavt
      541 grsysifdnn rqdptgltaa lqatdlagvl hmlycvlfhg tildpstasp kenytqntiq
      601 vaiqslrffn sfaalhlpaf qsivgaegls lafrhmassl lghcsqvsce sllhevivcv
      661 gyftvnhpdn qvivqsgrhp tvlqklcqlp fqyfsdprli kvlfpsliaa cynnhqnkii
      721 leqemscvll atfiqdlaqt pgqaenqpyq pkgkclgsqd ylelanrfpq qaweearqff
      781 lkkekk
//
LOCUS       XP_047288588             727 aa            linear   PRI 05-AUG-2025
DEFINITION  S phase cyclin A-associated protein in the endoplasmic reticulum
            isoform X21 [Homo sapiens].
ACCESSION   XP_047288588
VERSION     XP_047288588.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432632.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..727
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..727
                     /product="S phase cyclin A-associated protein in the
                     endoplasmic reticulum isoform X21"
                     /calculated_mol_wt=83419
     Region          <1..52
                     /region_name="SCAPER_N"
                     /note="S phase cyclin A-associated protein in the
                     endoplasmic reticulum; pfam16501"
                     /db_xref="CDD:406813"
     Region          <223..574
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <403..>637
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          656..688
                     /region_name="ZnF_U1"
                     /note="U1-like zinc finger; smart00451"
                     /db_xref="CDD:197732"
     CDS             1..727
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /coded_by="XM_047432632.1:386..2569"
                     /db_xref="GeneID:49855"
                     /db_xref="HGNC:HGNC:13081"
                     /db_xref="MIM:611611"
ORIGIN      
        1 mmldnyvrdf kalidwiqlq eklektdaqs rptslawevk kmspgrhvip spstdrinvt
       61 snarrslnfg gstgtvpapr laptgvswad kvkahhtgst asseitpaqs cppmtvqkas
      121 rknerkdaeg wetvqrgrpi rsrstavmpk vslateatrs kddsdkenvc llpdesiqkg
      181 qfvgdgtsnt ieshpkdslh scdhplaekt qftvstlddv knsgsirdny vrtseisavh
      241 idtecvsvml qagtpplqvn eekfpaekar ienemdpsdi snsmaevlak keeladrlek
      301 aneeaiasai aeeeqltrei eaeenndini etdndsdfsa smgsgsvsfc gmsmdwndvl
      361 adyeareswr qntswgdive eeparppghg ihmheklssp srkrtiaesk kkheekqmka
      421 qqlreklree ktlklqklle rekdvrkwke elldqrrrmm eekllhaefk revqlqaivk
      481 kaqeeeakvn eiafintlea qnkrhdvlsk lkeyeqrlne lqeerqrrqe ekqardeavq
      541 erkraleaer qarveellmk rkeqearieq qrqekekare daarerardr eerlaaltaa
      601 qqeameelqk kiqlkhdesi rrhmeqieqr kekaaelssg rhantdyapk ltpyerkkqc
      661 slcnvlisse vylfshvkgr khqqavrent siqgrelsde evvwhslvks inlkyiadef
      721 lhmykli
//
LOCUS       XP_047288589             708 aa            linear   PRI 05-AUG-2025
DEFINITION  S phase cyclin A-associated protein in the endoplasmic reticulum
            isoform X22 [Homo sapiens].
ACCESSION   XP_047288589
VERSION     XP_047288589.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432633.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..708
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..708
                     /product="S phase cyclin A-associated protein in the
                     endoplasmic reticulum isoform X22"
                     /calculated_mol_wt=79406
     Region          <2..101
                     /region_name="DUF4670"
                     /note="Domain of unknown function (DUF4670); pfam15709"
                     /db_xref="CDD:464815"
     Region          98..130
                     /region_name="ZnF_U1"
                     /note="U1-like zinc finger; smart00451"
                     /db_xref="CDD:197732"
     CDS             1..708
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /coded_by="XM_047432633.1:1107..3233"
                     /db_xref="GeneID:49855"
                     /db_xref="HGNC:HGNC:13081"
                     /db_xref="MIM:611611"
ORIGIN      
        1 mkrkeqeari eqqrqekeka redaarerar dreerlaalt aaqqeameel qkkiqlkhde
       61 sirrhmeqie qrkekaaels sgrhantdya pkltpyerkk qcslcnvlis sevylfshvk
      121 grkhqqavre ntsiqgrels deevehlslk kyiidivves tapaealkdg eerqknkkka
      181 kkikarmnfr akeyeslmet knsgsdspyk aklqrlakdl lkqvqvqdsg swannkvsal
      241 drtlgeitri lekenvadqi afqaagglta lehilqavvp atnvntvlri ppkslcnain
      301 vynltcnncs encsdvlfsn kitflmdlli hqltvyvpde nntilgrntn kqvfeglttg
      361 llkvsavvlg clianrpdgn cqpatpkipt qemknkpsqg dpfnnrvqdl isyvvnmgli
      421 dklcacflsv qgpvdenpkm aiflqhaagl lhamctlcfa vtgrsysifd nnrqdptglt
      481 aalqatdlag vlhmlycvlf hgtildpsta spkenytqnt iqvaiqslrf fnsfaalhlp
      541 afqsivgaeg lslafrhmas sllghcsqvs cesllheviv cvgyftvnhp dnqvivqsgr
      601 hptvlqklcq lpfqyfsdpr likvlfpsli aacynnhqnk iileqemscv llatfiqdla
      661 qtpgqaenqp yqpkgkclgs qdylelanrf pqqaweearq fflkkekk
//
LOCUS       XP_047288590             700 aa            linear   PRI 05-AUG-2025
DEFINITION  S phase cyclin A-associated protein in the endoplasmic reticulum
            isoform X23 [Homo sapiens].
ACCESSION   XP_047288590
VERSION     XP_047288590.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432634.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..700
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..700
                     /product="S phase cyclin A-associated protein in the
                     endoplasmic reticulum isoform X23"
                     /calculated_mol_wt=78441
     Region          114..211
                     /region_name="SCAPER_N"
                     /note="S phase cyclin A-associated protein in the
                     endoplasmic reticulum; pfam16501"
                     /db_xref="CDD:406813"
     Region          <370..>658
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     CDS             1..700
                     /gene="SCAPER"
                     /gene_synonym="IDDRP; MSTP063; Zfp291; ZNF291"
                     /coded_by="XM_047432634.1:87..2189"
                     /db_xref="GeneID:49855"
                     /db_xref="HGNC:HGNC:13081"
                     /db_xref="MIM:611611"
ORIGIN      
        1 mralrpggak slshlgvvgp sllpllllfs ktalpwrlss tpfsrshtpw vyvindlgie
       61 enlkndgkpk cqtggkskrt iqgthkttkq stavdckits sttgdkhfdk sptktrhprk
      121 idlrarywaf lfdnlrravd eiyvtcesdq svveckevlm mldnyvrdfk alidwiqlqe
      181 klektdaqsr ptslawevkk mspgrhvips pstdrinvts narrslnfgg stgtvpaprl
      241 aptgvswadk vkahhtgsta sseitpaqsc ppmtvqkasr knerkdaegw etvqrgrpir
      301 srstavmpkv slateatrsk ddsdkenvcl lpdesiqkgq fvgdgtsnti eshpkdslhs
      361 cdhplaektq ftvstlddvk nsgsirdnyv rtseisavhi dtecvsvmlq agtpplqvne
      421 ekfpaekari enemdpsdis nvsaanlsma evlakkeela drlekaneea iasaiaeeeq
      481 ltreieaeen ndinietdnd sdfsasmgsg svsfcgmsmd wndvladyea reswrqntsw
      541 gdiveeepar ppghgihmhe klsspsrkrt iaeskkkhee kqmkaqqlre klreektlkl
      601 qkllerekdv rkwkeelldq rrrmmeekll haefkrevql qaivkkaqee eakhkksdas
      661 nldmpnrsck vlplnesvkv lnllrkgkks yaevteisgk
//
LOCUS       XP_005254479             583 aa            linear   PRI 05-AUG-2025
DEFINITION  myelin expression factor 2 isoform X1 [Homo sapiens].
ACCESSION   XP_005254479
VERSION     XP_005254479.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254422.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Feb 3, 2014 this sequence version replaced XP_005254479.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..583
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..583
                     /product="myelin expression factor 2 isoform X1"
                     /calculated_mol_wt=62426
     Region          101..176
                     /region_name="RRM1_MYEF2"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     myelin expression factor 2 (MEF-2); cd12658"
                     /db_xref="CDD:410059"
     Region          124..>579
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     Region          233..308
                     /region_name="RRM2_MYEF2"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     myelin expression factor 2 (MEF-2); cd12660"
                     /db_xref="CDD:410061"
     Region          507..583
                     /region_name="RRM3_MYEF2"
                     /note="RNA recognition motif 3 (RRM3) found in vertebrate
                     myelin expression factor 2 (MEF-2); cd12662"
                     /db_xref="CDD:410063"
     CDS             1..583
                     /gene="MYEF2"
                     /gene_synonym="HsT18564; MEF-2; MST156; MSTP156; myEF-2"
                     /coded_by="XM_005254422.5:59..1810"
                     /db_xref="GeneID:50804"
                     /db_xref="HGNC:HGNC:17940"
                     /db_xref="MIM:619395"
ORIGIN      
        1 madankaevp gatggdsphl qpaeppgepr rephpaeaek qqpqhssssn gvkmendesa
       61 keeksdlkek stgskkanrf hpyskdknsg agekkgpnrn rvfisnipyd mkwqaikdlm
      121 rekvgevtyv elfkdaegks rgcgvvefkd eefvkkalet mnkydlsgrp lnikedpdge
      181 narralqrtg gsfpgghvpd mgsglmnlpp silnnpnipp evisnlqagr lgstifvanl
      241 dfkvgwkklk evfsiagtvk radikedkdg ksrgmgtvtf eqaieavqai smfngqflfd
      301 rpmhvkmddk svpheeyrsh dgktpqlprg lggigmglgp ggqpisasql niggvmgnlg
      361 pggigfggle amnsmggfgg vgrmgelyrg amtssmerdf grgdiginrg fgdsfgrlgs
      421 amiggfagri gssnmgpvgs gisggmgsmn svtggmgmgl drmsssfdrm gpgigailer
      481 sidmdrgfls gpmgsgmrer igskgnqifv rnlpfdltwq klkekfsqcg hvmfaeikme
      541 ngkskgcgtv rfdspesaek acrimngiki sgreidvrld rna
//
LOCUS       XP_005254481             559 aa            linear   PRI 05-AUG-2025
DEFINITION  myelin expression factor 2 isoform X2 [Homo sapiens].
ACCESSION   XP_005254481
VERSION     XP_005254481.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254424.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Feb 3, 2014 this sequence version replaced XP_005254481.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..559
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..559
                     /product="myelin expression factor 2 isoform X2"
                     /calculated_mol_wt=60234
     Region          101..176
                     /region_name="RRM1_MYEF2"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     myelin expression factor 2 (MEF-2); cd12658"
                     /db_xref="CDD:410059"
     Region          124..>555
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     Region          233..308
                     /region_name="RRM2_MYEF2"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     myelin expression factor 2 (MEF-2); cd12660"
                     /db_xref="CDD:410061"
     Region          483..559
                     /region_name="RRM3_MYEF2"
                     /note="RNA recognition motif 3 (RRM3) found in vertebrate
                     myelin expression factor 2 (MEF-2); cd12662"
                     /db_xref="CDD:410063"
     CDS             1..559
                     /gene="MYEF2"
                     /gene_synonym="HsT18564; MEF-2; MST156; MSTP156; myEF-2"
                     /coded_by="XM_005254424.5:59..1738"
                     /db_xref="GeneID:50804"
                     /db_xref="HGNC:HGNC:17940"
                     /db_xref="MIM:619395"
ORIGIN      
        1 madankaevp gatggdsphl qpaeppgepr rephpaeaek qqpqhssssn gvkmendesa
       61 keeksdlkek stgskkanrf hpyskdknsg agekkgpnrn rvfisnipyd mkwqaikdlm
      121 rekvgevtyv elfkdaegks rgcgvvefkd eefvkkalet mnkydlsgrp lnikedpdge
      181 narralqrtg gsfpgghvpd mgsglmnlpp silnnpnipp evisnlqagr lgstifvanl
      241 dfkvgwkklk evfsiagtvk radikedkdg ksrgmgtvtf eqaieavqai smfngqflfd
      301 rpmhvkmddk svpheeyrsh dgktpqlprg lggigmglgp ggqpisasql niggvmgnlg
      361 pggigfggle amnsmggfgg vgrmgelyrg amtssmerdf grgdiginrg fgdsfgrlgg
      421 gmgsmnsvtg gmgmgldrms ssfdrmgpgi gailersidm drgflsgpmg sgmrerigsk
      481 gnqifvrnlp fdltwqklke kfsqcghvmf aeikmengks kgcgtvrfds pesaekacri
      541 mngikisgre idvrldrna
//
LOCUS       XP_005254482             531 aa            linear   PRI 05-AUG-2025
DEFINITION  myelin expression factor 2 isoform X3 [Homo sapiens].
ACCESSION   XP_005254482
VERSION     XP_005254482.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254425.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Feb 3, 2014 this sequence version replaced XP_005254482.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..531
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..531
                     /product="myelin expression factor 2 isoform X3"
                     /calculated_mol_wt=56220
     Region          101..176
                     /region_name="RRM1_MYEF2"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     myelin expression factor 2 (MEF-2); cd12658"
                     /db_xref="CDD:410059"
     Region          233..308
                     /region_name="RRM2_MYEF2"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     myelin expression factor 2 (MEF-2); cd12660"
                     /db_xref="CDD:410061"
     CDS             1..531
                     /gene="MYEF2"
                     /gene_synonym="HsT18564; MEF-2; MST156; MSTP156; myEF-2"
                     /coded_by="XM_005254425.5:59..1654"
                     /db_xref="GeneID:50804"
                     /db_xref="HGNC:HGNC:17940"
                     /db_xref="MIM:619395"
ORIGIN      
        1 madankaevp gatggdsphl qpaeppgepr rephpaeaek qqpqhssssn gvkmendesa
       61 keeksdlkek stgskkanrf hpyskdknsg agekkgpnrn rvfisnipyd mkwqaikdlm
      121 rekvgevtyv elfkdaegks rgcgvvefkd eefvkkalet mnkydlsgrp lnikedpdge
      181 narralqrtg gsfpgghvpd mgsglmnlpp silnnpnipp evisnlqagr lgstifvanl
      241 dfkvgwkklk evfsiagtvk radikedkdg ksrgmgtvtf eqaieavqai smfngqflfd
      301 rpmhvkmddk svpheeyrsh dgktpqlprg lggigmglgp ggqpisasql niggvmgnlg
      361 pggmgmdgpg fggmnriggg igfggleamn smggfggvgr mgelyrgamt ssmerdfgrg
      421 diginrgfgd sfgrlgsami ggfagrigss nmgpvgsgis ggmgsmnsvt ggmgmgldrm
      481 sssfdrmgpg igailersid mdrgflsgpm gsgmrerigs kgnqifvrnv m
//
LOCUS       XP_016877774             514 aa            linear   PRI 05-AUG-2025
DEFINITION  myelin expression factor 2 isoform X4 [Homo sapiens].
ACCESSION   XP_016877774
VERSION     XP_016877774.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022285.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..514
                     /product="myelin expression factor 2 isoform X4"
                     /calculated_mol_wt=54627
     Region          101..176
                     /region_name="RRM1_MYEF2"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     myelin expression factor 2 (MEF-2); cd12658"
                     /db_xref="CDD:410059"
     Region          233..308
                     /region_name="RRM2_MYEF2"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     myelin expression factor 2 (MEF-2); cd12660"
                     /db_xref="CDD:410061"
     CDS             1..514
                     /gene="MYEF2"
                     /gene_synonym="HsT18564; MEF-2; MST156; MSTP156; myEF-2"
                     /coded_by="XM_017022285.2:59..1603"
                     /db_xref="GeneID:50804"
                     /db_xref="HGNC:HGNC:17940"
                     /db_xref="MIM:619395"
ORIGIN      
        1 madankaevp gatggdsphl qpaeppgepr rephpaeaek qqpqhssssn gvkmendesa
       61 keeksdlkek stgskkanrf hpyskdknsg agekkgpnrn rvfisnipyd mkwqaikdlm
      121 rekvgevtyv elfkdaegks rgcgvvefkd eefvkkalet mnkydlsgrp lnikedpdge
      181 narralqrtg gsfpgghvpd mgsglmnlpp silnnpnipp evisnlqagr lgstifvanl
      241 dfkvgwkklk evfsiagtvk radikedkdg ksrgmgtvtf eqaieavqai smfngqflfd
      301 rpmhvkmddk svpheeyrsh dgktpqlprg lggigmglgp ggqpisasql niggvmgnlg
      361 pggigfggle amnsmggfgg vgrmgelyrg amtssmerdf grgdiginrg fgdsfgrlgs
      421 amiggfagri gssnmgpvgs gisggmgsmn svtggmgmgl drmsssfdrm gpgigailer
      481 sidmdrgfls gpmgsgmrer igskgnqifv rnvm
//
LOCUS       XP_016877775             507 aa            linear   PRI 05-AUG-2025
DEFINITION  myelin expression factor 2 isoform X5 [Homo sapiens].
ACCESSION   XP_016877775
VERSION     XP_016877775.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022286.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..507
                     /product="myelin expression factor 2 isoform X5"
                     /calculated_mol_wt=54027
     Region          101..176
                     /region_name="RRM1_MYEF2"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     myelin expression factor 2 (MEF-2); cd12658"
                     /db_xref="CDD:410059"
     Region          233..308
                     /region_name="RRM2_MYEF2"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     myelin expression factor 2 (MEF-2); cd12660"
                     /db_xref="CDD:410061"
     CDS             1..507
                     /gene="MYEF2"
                     /gene_synonym="HsT18564; MEF-2; MST156; MSTP156; myEF-2"
                     /coded_by="XM_017022286.2:59..1582"
                     /db_xref="GeneID:50804"
                     /db_xref="HGNC:HGNC:17940"
                     /db_xref="MIM:619395"
ORIGIN      
        1 madankaevp gatggdsphl qpaeppgepr rephpaeaek qqpqhssssn gvkmendesa
       61 keeksdlkek stgskkanrf hpyskdknsg agekkgpnrn rvfisnipyd mkwqaikdlm
      121 rekvgevtyv elfkdaegks rgcgvvefkd eefvkkalet mnkydlsgrp lnikedpdge
      181 narralqrtg gsfpgghvpd mgsglmnlpp silnnpnipp evisnlqagr lgstifvanl
      241 dfkvgwkklk evfsiagtvk radikedkdg ksrgmgtvtf eqaieavqai smfngqflfd
      301 rpmhvkmddk svpheeyrsh dgktpqlprg lggigmglgp ggqpisasql niggvmgnlg
      361 pggmgmdgpg fggmnriggg igfggleamn smggfggvgr mgelyrgamt ssmerdfgrg
      421 diginrgfgd sfgrlgggmg smnsvtggmg mgldrmsssf drmgpgigai lersidmdrg
      481 flsgpmgsgm rerigskgnq ifvrnvm
//
LOCUS       XP_016877776             490 aa            linear   PRI 05-AUG-2025
DEFINITION  myelin expression factor 2 isoform X6 [Homo sapiens].
ACCESSION   XP_016877776
VERSION     XP_016877776.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022287.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..490
                     /product="myelin expression factor 2 isoform X6"
                     /calculated_mol_wt=52435
     Region          101..176
                     /region_name="RRM1_MYEF2"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     myelin expression factor 2 (MEF-2); cd12658"
                     /db_xref="CDD:410059"
     Region          233..308
                     /region_name="RRM2_MYEF2"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     myelin expression factor 2 (MEF-2); cd12660"
                     /db_xref="CDD:410061"
     CDS             1..490
                     /gene="MYEF2"
                     /gene_synonym="HsT18564; MEF-2; MST156; MSTP156; myEF-2"
                     /coded_by="XM_017022287.2:59..1531"
                     /db_xref="GeneID:50804"
                     /db_xref="HGNC:HGNC:17940"
                     /db_xref="MIM:619395"
ORIGIN      
        1 madankaevp gatggdsphl qpaeppgepr rephpaeaek qqpqhssssn gvkmendesa
       61 keeksdlkek stgskkanrf hpyskdknsg agekkgpnrn rvfisnipyd mkwqaikdlm
      121 rekvgevtyv elfkdaegks rgcgvvefkd eefvkkalet mnkydlsgrp lnikedpdge
      181 narralqrtg gsfpgghvpd mgsglmnlpp silnnpnipp evisnlqagr lgstifvanl
      241 dfkvgwkklk evfsiagtvk radikedkdg ksrgmgtvtf eqaieavqai smfngqflfd
      301 rpmhvkmddk svpheeyrsh dgktpqlprg lggigmglgp ggqpisasql niggvmgnlg
      361 pggigfggle amnsmggfgg vgrmgelyrg amtssmerdf grgdiginrg fgdsfgrlgg
      421 gmgsmnsvtg gmgmgldrms ssfdrmgpgi gailersidm drgflsgpmg sgmrerigsk
      481 gnqifvrnvm
//
LOCUS       XP_047288591             440 aa            linear   PRI 05-AUG-2025
DEFINITION  myelin expression factor 2 isoform X7 [Homo sapiens].
ACCESSION   XP_047288591
VERSION     XP_047288591.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432635.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..440
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..440
                     /product="myelin expression factor 2 isoform X7"
                     /calculated_mol_wt=46309
     Region          <1..16
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:473069"
     Region          73..148
                     /region_name="RRM2_MYEF2"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     myelin expression factor 2 (MEF-2); cd12660"
                     /db_xref="CDD:410061"
     Region          364..440
                     /region_name="RRM3_MYEF2"
                     /note="RNA recognition motif 3 (RRM3) found in vertebrate
                     myelin expression factor 2 (MEF-2); cd12662"
                     /db_xref="CDD:410063"
     CDS             1..440
                     /gene="MYEF2"
                     /gene_synonym="HsT18564; MEF-2; MST156; MSTP156; myEF-2"
                     /coded_by="XM_047432635.1:143..1465"
                     /db_xref="GeneID:50804"
                     /db_xref="HGNC:HGNC:17940"
                     /db_xref="MIM:619395"
ORIGIN      
        1 mnkydlsgrp lnikedpdge narralqrtg gsfpgghvpd mgsglmnlpp silnnpnipp
       61 evisnlqagr lgstifvanl dfkvgwkklk evfsiagtvk radikedkdg ksrgmgtvtf
      121 eqaieavqai smfngqflfd rpmhvkmddk svpheeyrsh dgktpqlprg lggigmglgp
      181 ggqpisasql niggvmgnlg pggmgmdgpg fggmnriggg igfggleamn smggfggvgr
      241 mgelyrgamt ssmerdfgrg diginrgfgd sfgrlgsami ggfagrigss nmgpvgsgis
      301 ggmgsmnsvt ggmgmgldrm sssfdrmgpg igailersid mdrgflsgpm gsgmrerigs
      361 kgnqifvrnl pfdltwqklk ekfsqcghvm faeikmengk skgcgtvrfd spesaekacr
      421 imngikisgr eidvrldrna
//
LOCUS       XP_011519959             436 aa            linear   PRI 05-AUG-2025
DEFINITION  myelin expression factor 2 isoform X8 [Homo sapiens].
ACCESSION   XP_011519959
VERSION     XP_011519959.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521657.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..436
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..436
                     /product="myelin expression factor 2 isoform X8"
                     /calculated_mol_wt=45990
     Region          69..144
                     /region_name="RRM2_MYEF2"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     myelin expression factor 2 (MEF-2); cd12660"
                     /db_xref="CDD:410061"
     Region          360..436
                     /region_name="RRM3_MYEF2"
                     /note="RNA recognition motif 3 (RRM3) found in vertebrate
                     myelin expression factor 2 (MEF-2); cd12662"
                     /db_xref="CDD:410063"
     CDS             1..436
                     /gene="MYEF2"
                     /gene_synonym="HsT18564; MEF-2; MST156; MSTP156; myEF-2"
                     /coded_by="XM_011521657.3:105..1415"
                     /db_xref="GeneID:50804"
                     /db_xref="HGNC:HGNC:17940"
                     /db_xref="MIM:619395"
ORIGIN      
        1 mnyqnvirrh kdpdgenarr alqrtggsfp gghvpdmgsg lmnlppsiln npnippevis
       61 nlqagrlgst ifvanldfkv gwkklkevfs iagtvkradi kedkdgksrg mgtvtfeqai
      121 eavqaismfn gqflfdrpmh vkmddksvph eeyrshdgkt pqlprglggi gmglgpggqp
      181 isasqlnigg vmgnlgpggm gmdgpgfggm nrigggigfg gleamnsmgg fggvgrmgel
      241 yrgamtssme rdfgrgdigi nrgfgdsfgr lgsamiggfa grigssnmgp vgsgisggmg
      301 smnsvtggmg mgldrmsssf drmgpgigai lersidmdrg flsgpmgsgm rerigskgnq
      361 ifvrnlpfdl twqklkekfs qcghvmfaei kmengkskgc gtvrfdspes aekacrimng
      421 ikisgreidv rldrna
//
LOCUS       XP_047288592             419 aa            linear   PRI 05-AUG-2025
DEFINITION  myelin expression factor 2 isoform X9 [Homo sapiens].
ACCESSION   XP_047288592
VERSION     XP_047288592.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432636.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..419
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..419
                     /product="myelin expression factor 2 isoform X9"
                     /calculated_mol_wt=44397
     Region          69..144
                     /region_name="RRM2_MYEF2"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     myelin expression factor 2 (MEF-2); cd12660"
                     /db_xref="CDD:410061"
     Region          71..>415
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     Region          343..419
                     /region_name="RRM3_MYEF2"
                     /note="RNA recognition motif 3 (RRM3) found in vertebrate
                     myelin expression factor 2 (MEF-2); cd12662"
                     /db_xref="CDD:410063"
     CDS             1..419
                     /gene="MYEF2"
                     /gene_synonym="HsT18564; MEF-2; MST156; MSTP156; myEF-2"
                     /coded_by="XM_047432636.1:105..1364"
                     /db_xref="GeneID:50804"
                     /db_xref="HGNC:HGNC:17940"
                     /db_xref="MIM:619395"
ORIGIN      
        1 mnyqnvirrh kdpdgenarr alqrtggsfp gghvpdmgsg lmnlppsiln npnippevis
       61 nlqagrlgst ifvanldfkv gwkklkevfs iagtvkradi kedkdgksrg mgtvtfeqai
      121 eavqaismfn gqflfdrpmh vkmddksvph eeyrshdgkt pqlprglggi gmglgpggqp
      181 isasqlnigg vmgnlgpggi gfggleamns mggfggvgrm gelyrgamts smerdfgrgd
      241 iginrgfgds fgrlgsamig gfagrigssn mgpvgsgisg gmgsmnsvtg gmgmgldrms
      301 ssfdrmgpgi gailersidm drgflsgpmg sgmrerigsk gnqifvrnlp fdltwqklke
      361 kfsqcghvmf aeikmengks kgcgtvrfds pesaekacri mngikisgre idvrldrna
//
LOCUS       XP_005254484             367 aa            linear   PRI 05-AUG-2025
DEFINITION  myelin expression factor 2 isoform X10 [Homo sapiens].
ACCESSION   XP_005254484
VERSION     XP_005254484.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254427.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..367
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..367
                     /product="myelin expression factor 2 isoform X10"
                     /calculated_mol_wt=40599
     Region          101..176
                     /region_name="RRM1_MYEF2"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     myelin expression factor 2 (MEF-2); cd12658"
                     /db_xref="CDD:410059"
     Region          233..308
                     /region_name="RRM2_MYEF2"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     myelin expression factor 2 (MEF-2); cd12660"
                     /db_xref="CDD:410061"
     CDS             1..367
                     /gene="MYEF2"
                     /gene_synonym="HsT18564; MEF-2; MST156; MSTP156; myEF-2"
                     /coded_by="XM_005254427.5:59..1162"
                     /db_xref="GeneID:50804"
                     /db_xref="HGNC:HGNC:17940"
                     /db_xref="MIM:619395"
ORIGIN      
        1 madankaevp gatggdsphl qpaeppgepr rephpaeaek qqpqhssssn gvkmendesa
       61 keeksdlkek stgskkanrf hpyskdknsg agekkgpnrn rvfisnipyd mkwqaikdlm
      121 rekvgevtyv elfkdaegks rgcgvvefkd eefvkkalet mnkydlsgrp lnikedpdge
      181 narralqrtg gsfpgghvpd mgsglmnlpp silnnpnipp evisnlqagr lgstifvanl
      241 dfkvgwkklk evfsiagtvk radikedkdg ksrgmgtvtf eqaieavqai smfngqflfd
      301 rpmhvkmddk svpheeyrsh dgktpqlpls hnlglvwsye dslallirkt ekisvtchff
      361 flfgnfs
//
LOCUS       XP_006720617             212 aa            linear   PRI 05-AUG-2025
DEFINITION  hepatoma-derived growth factor-related protein 3 isoform X1 [Homo
            sapiens].
ACCESSION   XP_006720617
VERSION     XP_006720617.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720554.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..212
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..212
                     /product="hepatoma-derived growth factor-related protein 3
                     isoform X1"
                     /calculated_mol_wt=23631
     Region          4..96
                     /region_name="PWWP_HDGFL3"
                     /note="PWWP domain found in Hepatoma-derived growth
                     factor-related protein 3 (HDGFL3); cd20150"
                     /db_xref="CDD:438978"
     Site            order(18,20..23,76,78)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:438978"
     Site            order(22,25,48)
                     /site_type="other"
                     /note="putative methyl-histone binding site [polypeptide
                     binding]"
                     /db_xref="CDD:438978"
     Site            23..26
                     /site_type="other"
                     /note="PWWP sequence motif"
                     /db_xref="CDD:438978"
     Site            order(33..37,39..40,56)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:438978"
     CDS             1..212
                     /gene="HDGFL3"
                     /gene_synonym="CGI-142; HDGF-2; HDGF2; HDGFRP3; HRP-3"
                     /coded_by="XM_006720554.5:410..1048"
                     /db_xref="GeneID:50810"
                     /db_xref="HGNC:HGNC:24937"
                     /db_xref="MIM:616643"
ORIGIN      
        1 marprpreyk agdlvfakmk gyphwparid elpegavkpp ankypifffg thetaflgpk
       61 dlfpykeykd kfgksnkrkg fneglweien npgvkftgyq aiqqqssset egeggntada
      121 sseeegdrve edgkgkrkne kagskrkksy tskksskqsr kspgdeddkd ckeeenksss
      181 eggdagndtr nttsdlqkts egkmlwtiie id
//
LOCUS       XP_047288593             327 aa            linear   PRI 05-AUG-2025
DEFINITION  complex I intermediate-associated protein 30, mitochondrial isoform
            X1 [Homo sapiens].
ACCESSION   XP_047288593
VERSION     XP_047288593.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432637.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..327
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..327
                     /product="complex I intermediate-associated protein 30,
                     mitochondrial isoform X1"
                     /calculated_mol_wt=37633
     Region          125..298
                     /region_name="CIA30"
                     /note="Complex I intermediate-associated protein 30
                     (CIA30); pfam08547"
                     /db_xref="CDD:462515"
     CDS             1..327
                     /gene="NDUFAF1"
                     /gene_synonym="CGI-65; CGI65; CIA30; MC1DN11"
                     /coded_by="XM_047432637.1:618..1601"
                     /db_xref="GeneID:51103"
                     /db_xref="HGNC:HGNC:18828"
                     /db_xref="MIM:606934"
ORIGIN      
        1 malvhkllrg tyflrkfskp tsalypflgi rfaeyssslq kpvaspgkas sqrktegdlq
       61 gdhqkevald itsseekpdv sfdkairdea iyhfrllkde ivdhwrgpeg hplhevlleq
      121 akvvwqfrgk edldkwtvts dktiggrsev flkmgknnqs allygtlsse apqdgestrs
      181 gycamisrip rgaferkmsy dwsqfntlyl rvrgdgrpwm vnikedtdff qrtnqmysyf
      241 mftrggpywq evkipfskff fsnrgrirdv qhelpldkis sigftladkv dgpffleidf
      301 igvftdpaht eefayenspe lnprlfk
//
LOCUS       XP_006720622             447 aa            linear   PRI 05-AUG-2025
DEFINITION  nucleolar and spindle-associated protein 1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_006720622
VERSION     XP_006720622.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720559.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..447
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..447
                     /product="nucleolar and spindle-associated protein 1
                     isoform X1"
                     /calculated_mol_wt=49947
     Region          164..442
                     /region_name="NUSAP"
                     /note="Nucleolar and spindle-associated protein;
                     pfam16006"
                     /db_xref="CDD:464970"
     CDS             1..447
                     /gene="NUSAP1"
                     /gene_synonym="ANKT; BM037; LNP; NUSAP; PRO0310p1; Q0310;
                     SAPL"
                     /coded_by="XM_006720559.4:78..1421"
                     /db_xref="GeneID:51203"
                     /db_xref="HGNC:HGNC:18538"
                     /db_xref="MIM:612818"
ORIGIN      
        1 miipsleeld slkysdlqnl akslglranl ratkllkalk gyikhearkg nenqdesqts
       61 asscdeteiq isnqeeaerq plghvtktrr rcktvrvdpd sqqnhseiki snptefqnhe
      121 kqesqdlrat akvpsppdeh qeaenavssg krgingnrds kvpsegkksl ytdesskpgk
      181 nkrtaittpn fkklheahfk emesidqyie rkkkhfeehn smnelkqqpi nkggvrtpvp
      241 prgrlsvast pisqrrsqgr scgpasqstl glkgslkrsa isaaktgvrf saatkdnehk
      301 rsltktpark sahvtvsggt pkgeavlgth klktitgnsa avitpfkltt eatqtpvsnk
      361 kpvfdlkasl srplnyephk gklkpwgqsk ennylnqhvn rinfykktyk qphlqtkeeq
      421 rkkreqerke kkakvlgmrr glilaed
//
LOCUS       XP_005254485             446 aa            linear   PRI 05-AUG-2025
DEFINITION  nucleolar and spindle-associated protein 1 isoform X2 [Homo
            sapiens].
ACCESSION   XP_005254485
VERSION     XP_005254485.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254428.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..446
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..446
                     /product="nucleolar and spindle-associated protein 1
                     isoform X2"
                     /calculated_mol_wt=49818
     Region          164..441
                     /region_name="NUSAP"
                     /note="Nucleolar and spindle-associated protein;
                     pfam16006"
                     /db_xref="CDD:464970"
     CDS             1..446
                     /gene="NUSAP1"
                     /gene_synonym="ANKT; BM037; LNP; NUSAP; PRO0310p1; Q0310;
                     SAPL"
                     /coded_by="XM_005254428.4:78..1418"
                     /db_xref="GeneID:51203"
                     /db_xref="HGNC:HGNC:18538"
                     /db_xref="MIM:612818"
ORIGIN      
        1 miipsleeld slkysdlqnl akslglranl ratkllkalk gyikhearkg nenqdesqts
       61 asscdeteiq isnqeeaerq plghvtktrr rcktvrvdpd sqqnhseiki snptefqnhe
      121 kqesqdlrat akvpsppdeh qeaenavssg krgingnrds kvpsegkksl ytdesskpgk
      181 nkrtaittpn fkklheahfk emesidqyie rkkkhfeehn smnelkqpin kggvrtpvpp
      241 rgrlsvastp isqrrsqgrs cgpasqstlg lkgslkrsai saaktgvrfs aatkdnehkr
      301 sltktparks ahvtvsggtp kgeavlgthk lktitgnsaa vitpfkltte atqtpvsnkk
      361 pvfdlkasls rplnyephkg klkpwgqske nnylnqhvnr infykktykq phlqtkeeqr
      421 kkreqerkek kakvlgmrrg lilaed
//
LOCUS       XP_006720623             446 aa            linear   PRI 05-AUG-2025
DEFINITION  nucleolar and spindle-associated protein 1 isoform X3 [Homo
            sapiens].
ACCESSION   XP_006720623
VERSION     XP_006720623.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720560.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..446
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..446
                     /product="nucleolar and spindle-associated protein 1
                     isoform X3"
                     /calculated_mol_wt=49818
     Region          163..441
                     /region_name="NUSAP"
                     /note="Nucleolar and spindle-associated protein;
                     pfam16006"
                     /db_xref="CDD:464970"
     CDS             1..446
                     /gene="NUSAP1"
                     /gene_synonym="ANKT; BM037; LNP; NUSAP; PRO0310p1; Q0310;
                     SAPL"
                     /coded_by="XM_006720560.5:78..1418"
                     /db_xref="GeneID:51203"
                     /db_xref="HGNC:HGNC:18538"
                     /db_xref="MIM:612818"
ORIGIN      
        1 miipsleeld slkysdlqnl akslglranl ratkllkalk gyikhearkg nenqdesqts
       61 asscdeteiq isnqeeaerq plghvtktrr rcktvrvdpd sqnhseikis nptefqnhek
      121 qesqdlrata kvpsppdehq eaenavssgk rgingnrdsk vpsegkksly tdesskpgkn
      181 krtaittpnf kklheahfke mesidqyier kkkhfeehns mnelkqqpin kggvrtpvpp
      241 rgrlsvastp isqrrsqgrs cgpasqstlg lkgslkrsai saaktgvrfs aatkdnehkr
      301 sltktparks ahvtvsggtp kgeavlgthk lktitgnsaa vitpfkltte atqtpvsnkk
      361 pvfdlkasls rplnyephkg klkpwgqske nnylnqhvnr infykktykq phlqtkeeqr
      421 kkreqerkek kakvlgmrrg lilaed
//
LOCUS       XP_047288595             445 aa            linear   PRI 05-AUG-2025
DEFINITION  nucleolar and spindle-associated protein 1 isoform X4 [Homo
            sapiens].
ACCESSION   XP_047288595
VERSION     XP_047288595.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432639.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..445
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..445
                     /product="nucleolar and spindle-associated protein 1
                     isoform X4"
                     /calculated_mol_wt=49690
     Region          163..440
                     /region_name="NUSAP"
                     /note="Nucleolar and spindle-associated protein;
                     pfam16006"
                     /db_xref="CDD:464970"
     CDS             1..445
                     /gene="NUSAP1"
                     /gene_synonym="ANKT; BM037; LNP; NUSAP; PRO0310p1; Q0310;
                     SAPL"
                     /coded_by="XM_047432639.1:78..1415"
                     /db_xref="GeneID:51203"
                     /db_xref="HGNC:HGNC:18538"
                     /db_xref="MIM:612818"
ORIGIN      
        1 miipsleeld slkysdlqnl akslglranl ratkllkalk gyikhearkg nenqdesqts
       61 asscdeteiq isnqeeaerq plghvtktrr rcktvrvdpd sqnhseikis nptefqnhek
      121 qesqdlrata kvpsppdehq eaenavssgk rgingnrdsk vpsegkksly tdesskpgkn
      181 krtaittpnf kklheahfke mesidqyier kkkhfeehns mnelkqpink ggvrtpvppr
      241 grlsvastpi sqrrsqgrsc gpasqstlgl kgslkrsais aaktgvrfsa atkdnehkrs
      301 ltktparksa hvtvsggtpk geavlgthkl ktitgnsaav itpfklttea tqtpvsnkkp
      361 vfdlkaslsr plnyephkgk lkpwgqsken nylnqhvnri nfykktykqp hlqtkeeqrk
      421 kreqerkekk akvlgmrrgl ilaed
//
LOCUS       XP_006720624             432 aa            linear   PRI 05-AUG-2025
DEFINITION  nucleolar and spindle-associated protein 1 isoform X5 [Homo
            sapiens].
ACCESSION   XP_006720624
VERSION     XP_006720624.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720561.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..432
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..432
                     /product="nucleolar and spindle-associated protein 1
                     isoform X5"
                     /calculated_mol_wt=48193
     Region          7..>170
                     /region_name="PRK12678"
                     /note="transcription termination factor Rho; Provisional"
                     /db_xref="CDD:237171"
     Region          149..427
                     /region_name="NUSAP"
                     /note="Nucleolar and spindle-associated protein;
                     pfam16006"
                     /db_xref="CDD:464970"
     CDS             1..432
                     /gene="NUSAP1"
                     /gene_synonym="ANKT; BM037; LNP; NUSAP; PRO0310p1; Q0310;
                     SAPL"
                     /coded_by="XM_006720561.4:78..1376"
                     /db_xref="GeneID:51203"
                     /db_xref="HGNC:HGNC:18538"
                     /db_xref="MIM:612818"
ORIGIN      
        1 miipsleeld slkysdlqnl akslglranl ratkllkalk gyikhearkg nenqdesqts
       61 asscdeteiq isnqeeaerq plghvtktrr rcktvrvdpd sqnhekqesq dlratakvps
      121 ppdehqeaen avssgkrgin gnrdskvpse gkkslytdes skpgknkrta ittpnfkklh
      181 eahfkemesi dqyierkkkh feehnsmnel kqqpinkggv rtpvpprgrl svastpisqr
      241 rsqgrscgpa sqstlglkgs lkrsaisaak tgvrfsaatk dnehkrsltk tparksahvt
      301 vsggtpkgea vlgthklkti tgnsaavitp fkltteatqt pvsnkkpvfd lkaslsrpln
      361 yephkgklkp wgqskennyl nqhvnrinfy kktykqphlq tkeeqrkkre qerkekkakv
      421 lgmrrglila ed
//
LOCUS       XP_047288596             431 aa            linear   PRI 05-AUG-2025
DEFINITION  nucleolar and spindle-associated protein 1 isoform X6 [Homo
            sapiens].
ACCESSION   XP_047288596
VERSION     XP_047288596.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432640.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..431
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..431
                     /product="nucleolar and spindle-associated protein 1
                     isoform X6"
                     /calculated_mol_wt=48065
     Region          7..>170
                     /region_name="PRK12678"
                     /note="transcription termination factor Rho; Provisional"
                     /db_xref="CDD:237171"
     Region          149..426
                     /region_name="NUSAP"
                     /note="Nucleolar and spindle-associated protein;
                     pfam16006"
                     /db_xref="CDD:464970"
     CDS             1..431
                     /gene="NUSAP1"
                     /gene_synonym="ANKT; BM037; LNP; NUSAP; PRO0310p1; Q0310;
                     SAPL"
                     /coded_by="XM_047432640.1:78..1373"
                     /db_xref="GeneID:51203"
                     /db_xref="HGNC:HGNC:18538"
                     /db_xref="MIM:612818"
ORIGIN      
        1 miipsleeld slkysdlqnl akslglranl ratkllkalk gyikhearkg nenqdesqts
       61 asscdeteiq isnqeeaerq plghvtktrr rcktvrvdpd sqnhekqesq dlratakvps
      121 ppdehqeaen avssgkrgin gnrdskvpse gkkslytdes skpgknkrta ittpnfkklh
      181 eahfkemesi dqyierkkkh feehnsmnel kqpinkggvr tpvpprgrls vastpisqrr
      241 sqgrscgpas qstlglkgsl krsaisaakt gvrfsaatkd nehkrsltkt parksahvtv
      301 sggtpkgeav lgthklktit gnsaavitpf kltteatqtp vsnkkpvfdl kaslsrplny
      361 ephkgklkpw gqskennyln qhvnrinfyk ktykqphlqt keeqrkkreq erkekkakvl
      421 gmrrglilae d
//
LOCUS       XP_005254487             425 aa            linear   PRI 05-AUG-2025
DEFINITION  nucleolar and spindle-associated protein 1 isoform X7 [Homo
            sapiens].
ACCESSION   XP_005254487
VERSION     XP_005254487.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254430.6
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..425
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..425
                     /product="nucleolar and spindle-associated protein 1
                     isoform X7"
                     /calculated_mol_wt=47439
     Region          143..420
                     /region_name="NUSAP"
                     /note="Nucleolar and spindle-associated protein;
                     pfam16006"
                     /db_xref="CDD:464970"
     CDS             1..425
                     /gene="NUSAP1"
                     /gene_synonym="ANKT; BM037; LNP; NUSAP; PRO0310p1; Q0310;
                     SAPL"
                     /coded_by="XM_005254430.6:78..1355"
                     /db_xref="GeneID:51203"
                     /db_xref="HGNC:HGNC:18538"
                     /db_xref="MIM:612818"
ORIGIN      
        1 miipsleeld slkysdlqnl akslglranl ratkllkalk gyikhearkg nenqdesqts
       61 asscdeteiq isnqeeaerq plghvtktrr rcktvrvdpd sqnhekqesq dlratakvps
      121 ppdehqeaen avssgnrdsk vpsegkksly tdesskpgkn krtaittpnf kklheahfke
      181 mesidqyier kkkhfeehns mnelkqpink ggvrtpvppr grlsvastpi sqrrsqgrsc
      241 gpasqstlgl kgslkrsais aaktgvrfsa atkdnehkrs ltktparksa hvtvsggtpk
      301 geavlgthkl ktitgnsaav itpfklttea tqtpvsnkkp vfdlkaslsr plnyephkgk
      361 lkpwgqsken nylnqhvnri nfykktykqp hlqtkeeqrk kreqerkekk akvlgmrrgl
      421 ilaed
//
LOCUS       XP_006720625             408 aa            linear   PRI 05-AUG-2025
DEFINITION  nucleolar and spindle-associated protein 1 isoform X8 [Homo
            sapiens].
ACCESSION   XP_006720625
VERSION     XP_006720625.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720562.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..408
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..408
                     /product="nucleolar and spindle-associated protein 1
                     isoform X8"
                     /calculated_mol_wt=45567
     Region          164..403
                     /region_name="NUSAP"
                     /note="Nucleolar and spindle-associated protein;
                     pfam16006"
                     /db_xref="CDD:464970"
     CDS             1..408
                     /gene="NUSAP1"
                     /gene_synonym="ANKT; BM037; LNP; NUSAP; PRO0310p1; Q0310;
                     SAPL"
                     /coded_by="XM_006720562.4:78..1304"
                     /db_xref="GeneID:51203"
                     /db_xref="HGNC:HGNC:18538"
                     /db_xref="MIM:612818"
ORIGIN      
        1 miipsleeld slkysdlqnl akslglranl ratkllkalk gyikhearkg nenqdesqts
       61 asscdeteiq isnqeeaerq plghvtktrr rcktvrvdpd sqqnhseiki snptefqnhe
      121 kqesqdlrat akvpsppdeh qeaenavssg krgingnrds kvpsegkksl ytdesskpgk
      181 nkrtaittpn fkklheahfk emesidqyie rkkkhfeehn smnelkqqpi nkggvrtpvp
      241 prgrlsvast pisqrrsqgr scgpasqstl glkgslkrsa isaaktgvrf saatkdnehk
      301 rsltktpark sahvtvsggt pkgeavlgth klktitgnsa agklkpwgqs kennylnqhv
      361 nrinfykkty kqphlqtkee qrkkreqerk ekkakvlgmr rglilaed
//
LOCUS       XP_005254488             407 aa            linear   PRI 05-AUG-2025
DEFINITION  nucleolar and spindle-associated protein 1 isoform X9 [Homo
            sapiens].
ACCESSION   XP_005254488
VERSION     XP_005254488.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254431.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..407
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..407
                     /product="nucleolar and spindle-associated protein 1
                     isoform X9"
                     /calculated_mol_wt=45439
     Region          164..402
                     /region_name="NUSAP"
                     /note="Nucleolar and spindle-associated protein;
                     pfam16006"
                     /db_xref="CDD:464970"
     CDS             1..407
                     /gene="NUSAP1"
                     /gene_synonym="ANKT; BM037; LNP; NUSAP; PRO0310p1; Q0310;
                     SAPL"
                     /coded_by="XM_005254431.4:78..1301"
                     /db_xref="GeneID:51203"
                     /db_xref="HGNC:HGNC:18538"
                     /db_xref="MIM:612818"
ORIGIN      
        1 miipsleeld slkysdlqnl akslglranl ratkllkalk gyikhearkg nenqdesqts
       61 asscdeteiq isnqeeaerq plghvtktrr rcktvrvdpd sqqnhseiki snptefqnhe
      121 kqesqdlrat akvpsppdeh qeaenavssg krgingnrds kvpsegkksl ytdesskpgk
      181 nkrtaittpn fkklheahfk emesidqyie rkkkhfeehn smnelkqpin kggvrtpvpp
      241 rgrlsvastp isqrrsqgrs cgpasqstlg lkgslkrsai saaktgvrfs aatkdnehkr
      301 sltktparks ahvtvsggtp kgeavlgthk lktitgnsaa gklkpwgqsk ennylnqhvn
      361 rinfykktyk qphlqtkeeq rkkreqerke kkakvlgmrr glilaed
//
LOCUS       XP_047288597             402 aa            linear   PRI 05-AUG-2025
DEFINITION  nucleolar and spindle-associated protein 1 isoform X10 [Homo
            sapiens].
ACCESSION   XP_047288597
VERSION     XP_047288597.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432641.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..402
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..402
                     /product="nucleolar and spindle-associated protein 1
                     isoform X10"
                     /calculated_mol_wt=44942
     Region          158..397
                     /region_name="NUSAP"
                     /note="Nucleolar and spindle-associated protein;
                     pfam16006"
                     /db_xref="CDD:464970"
     CDS             1..402
                     /gene="NUSAP1"
                     /gene_synonym="ANKT; BM037; LNP; NUSAP; PRO0310p1; Q0310;
                     SAPL"
                     /coded_by="XM_047432641.1:78..1286"
                     /db_xref="GeneID:51203"
                     /db_xref="HGNC:HGNC:18538"
                     /db_xref="MIM:612818"
ORIGIN      
        1 miipsleeld slkysdlqnl akslglranl ratkllkalk gyikhearkg nenqdesqts
       61 asscdeteiq isnqeeaerq plghvtktrr rcktvrvdpd sqqnhseiki snptefqnhe
      121 kqesqdlrat akvpsppdeh qeaenavssg nrdskvpseg kkslytdess kpgknkrtai
      181 ttpnfkklhe ahfkemesid qyierkkkhf eehnsmnelk qqpinkggvr tpvpprgrls
      241 vastpisqrr sqgrscgpas qstlglkgsl krsaisaakt gvrfsaatkd nehkrsltkt
      301 parksahvtv sggtpkgeav lgthklktit gnsaagklkp wgqskennyl nqhvnrinfy
      361 kktykqphlq tkeeqrkkre qerkekkakv lgmrrglila ed
//
LOCUS       XP_006720626             401 aa            linear   PRI 05-AUG-2025
DEFINITION  nucleolar and spindle-associated protein 1 isoform X11 [Homo
            sapiens].
ACCESSION   XP_006720626
VERSION     XP_006720626.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720563.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..401
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..401
                     /product="nucleolar and spindle-associated protein 1
                     isoform X11"
                     /calculated_mol_wt=44814
     Region          158..396
                     /region_name="NUSAP"
                     /note="Nucleolar and spindle-associated protein;
                     pfam16006"
                     /db_xref="CDD:464970"
     CDS             1..401
                     /gene="NUSAP1"
                     /gene_synonym="ANKT; BM037; LNP; NUSAP; PRO0310p1; Q0310;
                     SAPL"
                     /coded_by="XM_006720563.4:78..1283"
                     /db_xref="GeneID:51203"
                     /db_xref="HGNC:HGNC:18538"
                     /db_xref="MIM:612818"
ORIGIN      
        1 miipsleeld slkysdlqnl akslglranl ratkllkalk gyikhearkg nenqdesqts
       61 asscdeteiq isnqeeaerq plghvtktrr rcktvrvdpd sqqnhseiki snptefqnhe
      121 kqesqdlrat akvpsppdeh qeaenavssg nrdskvpseg kkslytdess kpgknkrtai
      181 ttpnfkklhe ahfkemesid qyierkkkhf eehnsmnelk qpinkggvrt pvpprgrlsv
      241 astpisqrrs qgrscgpasq stlglkgslk rsaisaaktg vrfsaatkdn ehkrsltktp
      301 arksahvtvs ggtpkgeavl gthklktitg nsaagklkpw gqskennyln qhvnrinfyk
      361 ktykqphlqt keeqrkkreq erkekkakvl gmrrglilae d
//
LOCUS       XP_047288598             401 aa            linear   PRI 05-AUG-2025
DEFINITION  nucleolar and spindle-associated protein 1 isoform X12 [Homo
            sapiens].
ACCESSION   XP_047288598
VERSION     XP_047288598.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432642.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..401
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..401
                     /product="nucleolar and spindle-associated protein 1
                     isoform X12"
                     /calculated_mol_wt=44814
     Region          157..396
                     /region_name="NUSAP"
                     /note="Nucleolar and spindle-associated protein;
                     pfam16006"
                     /db_xref="CDD:464970"
     CDS             1..401
                     /gene="NUSAP1"
                     /gene_synonym="ANKT; BM037; LNP; NUSAP; PRO0310p1; Q0310;
                     SAPL"
                     /coded_by="XM_047432642.1:78..1283"
                     /db_xref="GeneID:51203"
                     /db_xref="HGNC:HGNC:18538"
                     /db_xref="MIM:612818"
ORIGIN      
        1 miipsleeld slkysdlqnl akslglranl ratkllkalk gyikhearkg nenqdesqts
       61 asscdeteiq isnqeeaerq plghvtktrr rcktvrvdpd sqnhseikis nptefqnhek
      121 qesqdlrata kvpsppdehq eaenavssgn rdskvpsegk kslytdessk pgknkrtait
      181 tpnfkklhea hfkemesidq yierkkkhfe ehnsmnelkq qpinkggvrt pvpprgrlsv
      241 astpisqrrs qgrscgpasq stlglkgslk rsaisaaktg vrfsaatkdn ehkrsltktp
      301 arksahvtvs ggtpkgeavl gthklktitg nsaagklkpw gqskennyln qhvnrinfyk
      361 ktykqphlqt keeqrkkreq erkekkakvl gmrrglilae d
//
LOCUS       XP_047288599             400 aa            linear   PRI 05-AUG-2025
DEFINITION  nucleolar and spindle-associated protein 1 isoform X13 [Homo
            sapiens].
ACCESSION   XP_047288599
VERSION     XP_047288599.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432643.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..400
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..400
                     /product="nucleolar and spindle-associated protein 1
                     isoform X13"
                     /calculated_mol_wt=44685
     Region          157..395
                     /region_name="NUSAP"
                     /note="Nucleolar and spindle-associated protein;
                     pfam16006"
                     /db_xref="CDD:464970"
     CDS             1..400
                     /gene="NUSAP1"
                     /gene_synonym="ANKT; BM037; LNP; NUSAP; PRO0310p1; Q0310;
                     SAPL"
                     /coded_by="XM_047432643.1:78..1280"
                     /db_xref="GeneID:51203"
                     /db_xref="HGNC:HGNC:18538"
                     /db_xref="MIM:612818"
ORIGIN      
        1 miipsleeld slkysdlqnl akslglranl ratkllkalk gyikhearkg nenqdesqts
       61 asscdeteiq isnqeeaerq plghvtktrr rcktvrvdpd sqnhseikis nptefqnhek
      121 qesqdlrata kvpsppdehq eaenavssgn rdskvpsegk kslytdessk pgknkrtait
      181 tpnfkklhea hfkemesidq yierkkkhfe ehnsmnelkq pinkggvrtp vpprgrlsva
      241 stpisqrrsq grscgpasqs tlglkgslkr saisaaktgv rfsaatkdne hkrsltktpa
      301 rksahvtvsg gtpkgeavlg thklktitgn saagklkpwg qskennylnq hvnrinfykk
      361 tykqphlqtk eeqrkkreqe rkekkakvlg mrrglilaed
//
LOCUS       XP_047288600             393 aa            linear   PRI 05-AUG-2025
DEFINITION  nucleolar and spindle-associated protein 1 isoform X14 [Homo
            sapiens].
ACCESSION   XP_047288600
VERSION     XP_047288600.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432644.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..393
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..393
                     /product="nucleolar and spindle-associated protein 1
                     isoform X14"
                     /calculated_mol_wt=43814
     Region          149..388
                     /region_name="NUSAP"
                     /note="Nucleolar and spindle-associated protein;
                     pfam16006"
                     /db_xref="CDD:464970"
     CDS             1..393
                     /gene="NUSAP1"
                     /gene_synonym="ANKT; BM037; LNP; NUSAP; PRO0310p1; Q0310;
                     SAPL"
                     /coded_by="XM_047432644.1:78..1259"
                     /db_xref="GeneID:51203"
                     /db_xref="HGNC:HGNC:18538"
                     /db_xref="MIM:612818"
ORIGIN      
        1 miipsleeld slkysdlqnl akslglranl ratkllkalk gyikhearkg nenqdesqts
       61 asscdeteiq isnqeeaerq plghvtktrr rcktvrvdpd sqnhekqesq dlratakvps
      121 ppdehqeaen avssgkrgin gnrdskvpse gkkslytdes skpgknkrta ittpnfkklh
      181 eahfkemesi dqyierkkkh feehnsmnel kqqpinkggv rtpvpprgrl svastpisqr
      241 rsqgrscgpa sqstlglkgs lkrsaisaak tgvrfsaatk dnehkrsltk tparksahvt
      301 vsggtpkgea vlgthklkti tgnsaagklk pwgqskenny lnqhvnrinf ykktykqphl
      361 qtkeeqrkkr eqerkekkak vlgmrrglil aed
//
LOCUS       XP_047288601             392 aa            linear   PRI 05-AUG-2025
DEFINITION  nucleolar and spindle-associated protein 1 isoform X15 [Homo
            sapiens].
ACCESSION   XP_047288601
VERSION     XP_047288601.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432645.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..392
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..392
                     /product="nucleolar and spindle-associated protein 1
                     isoform X15"
                     /calculated_mol_wt=43685
     Region          149..387
                     /region_name="NUSAP"
                     /note="Nucleolar and spindle-associated protein;
                     pfam16006"
                     /db_xref="CDD:464970"
     CDS             1..392
                     /gene="NUSAP1"
                     /gene_synonym="ANKT; BM037; LNP; NUSAP; PRO0310p1; Q0310;
                     SAPL"
                     /coded_by="XM_047432645.1:78..1256"
                     /db_xref="GeneID:51203"
                     /db_xref="HGNC:HGNC:18538"
                     /db_xref="MIM:612818"
ORIGIN      
        1 miipsleeld slkysdlqnl akslglranl ratkllkalk gyikhearkg nenqdesqts
       61 asscdeteiq isnqeeaerq plghvtktrr rcktvrvdpd sqnhekqesq dlratakvps
      121 ppdehqeaen avssgkrgin gnrdskvpse gkkslytdes skpgknkrta ittpnfkklh
      181 eahfkemesi dqyierkkkh feehnsmnel kqpinkggvr tpvpprgrls vastpisqrr
      241 sqgrscgpas qstlglkgsl krsaisaakt gvrfsaatkd nehkrsltkt parksahvtv
      301 sggtpkgeav lgthklktit gnsaagklkp wgqskennyl nqhvnrinfy kktykqphlq
      361 tkeeqrkkre qerkekkakv lgmrrglila ed
//
LOCUS       XP_047288602             387 aa            linear   PRI 05-AUG-2025
DEFINITION  nucleolar and spindle-associated protein 1 isoform X16 [Homo
            sapiens].
ACCESSION   XP_047288602
VERSION     XP_047288602.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432646.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..387
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..387
                     /product="nucleolar and spindle-associated protein 1
                     isoform X16"
                     /calculated_mol_wt=43188
     Region          143..382
                     /region_name="NUSAP"
                     /note="Nucleolar and spindle-associated protein;
                     pfam16006"
                     /db_xref="CDD:464970"
     CDS             1..387
                     /gene="NUSAP1"
                     /gene_synonym="ANKT; BM037; LNP; NUSAP; PRO0310p1; Q0310;
                     SAPL"
                     /coded_by="XM_047432646.1:78..1241"
                     /db_xref="GeneID:51203"
                     /db_xref="HGNC:HGNC:18538"
                     /db_xref="MIM:612818"
ORIGIN      
        1 miipsleeld slkysdlqnl akslglranl ratkllkalk gyikhearkg nenqdesqts
       61 asscdeteiq isnqeeaerq plghvtktrr rcktvrvdpd sqnhekqesq dlratakvps
      121 ppdehqeaen avssgnrdsk vpsegkksly tdesskpgkn krtaittpnf kklheahfke
      181 mesidqyier kkkhfeehns mnelkqqpin kggvrtpvpp rgrlsvastp isqrrsqgrs
      241 cgpasqstlg lkgslkrsai saaktgvrfs aatkdnehkr sltktparks ahvtvsggtp
      301 kgeavlgthk lktitgnsaa gklkpwgqsk ennylnqhvn rinfykktyk qphlqtkeeq
      361 rkkreqerke kkakvlgmrr glilaed
//
LOCUS       XP_016877783             386 aa            linear   PRI 05-AUG-2025
DEFINITION  nucleolar and spindle-associated protein 1 isoform X17 [Homo
            sapiens].
ACCESSION   XP_016877783
VERSION     XP_016877783.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022294.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..386
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..386
                     /product="nucleolar and spindle-associated protein 1
                     isoform X17"
                     /calculated_mol_wt=43060
     Region          143..381
                     /region_name="NUSAP"
                     /note="Nucleolar and spindle-associated protein;
                     pfam16006"
                     /db_xref="CDD:464970"
     CDS             1..386
                     /gene="NUSAP1"
                     /gene_synonym="ANKT; BM037; LNP; NUSAP; PRO0310p1; Q0310;
                     SAPL"
                     /coded_by="XM_017022294.3:78..1238"
                     /db_xref="GeneID:51203"
                     /db_xref="HGNC:HGNC:18538"
                     /db_xref="MIM:612818"
ORIGIN      
        1 miipsleeld slkysdlqnl akslglranl ratkllkalk gyikhearkg nenqdesqts
       61 asscdeteiq isnqeeaerq plghvtktrr rcktvrvdpd sqnhekqesq dlratakvps
      121 ppdehqeaen avssgnrdsk vpsegkksly tdesskpgkn krtaittpnf kklheahfke
      181 mesidqyier kkkhfeehns mnelkqpink ggvrtpvppr grlsvastpi sqrrsqgrsc
      241 gpasqstlgl kgslkrsais aaktgvrfsa atkdnehkrs ltktparksa hvtvsggtpk
      301 geavlgthkl ktitgnsaag klkpwgqske nnylnqhvnr infykktykq phlqtkeeqr
      361 kkreqerkek kakvlgmrrg lilaed
//
LOCUS       XP_011519962             261 aa            linear   PRI 05-AUG-2025
DEFINITION  ras-like protein family member 12 isoform X1 [Homo sapiens].
ACCESSION   XP_011519962
VERSION     XP_011519962.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521660.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..261
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..261
                     /product="ras-like protein family member 12 isoform X1"
                     /calculated_mol_wt=29553
     Region          27..180
                     /region_name="P-loop containing Nucleoside Triphosphate
                     Hydrolases"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; cl38936"
                     /db_xref="CDD:476819"
     Site            47
                     /site_type="other"
                     /note="G2 box"
                     /db_xref="CDD:206713"
     Site            50..52
                     /site_type="other"
                     /note="Switch I region"
                     /db_xref="CDD:206713"
     Site            69..72
                     /site_type="other"
                     /note="G3 box"
                     /db_xref="CDD:206713"
     Site            order(71..72,87..88)
                     /site_type="other"
                     /note="Switch II region"
                     /db_xref="CDD:206713"
     Site            129..132
                     /site_type="other"
                     /note="G4 box"
                     /db_xref="CDD:206713"
     Site            159..161
                     /site_type="other"
                     /note="G5 box"
                     /db_xref="CDD:206713"
     CDS             1..261
                     /gene="RASL12"
                     /gene_synonym="RIS"
                     /coded_by="XM_011521660.4:107..892"
                     /db_xref="GeneID:51285"
                     /db_xref="HGNC:HGNC:30289"
ORIGIN      
        1 mkprtlemgl fscrrtssgh pwilhygkls ltvkfltkrf iseydpnled tysseetvdh
       61 qpvhlrvmdt adldtprnce rylnwahafl vvysvdsrqs fdssssylel lalhaketqr
      121 sipalllgnk ldmaqyrqvt kaegvalagr fgclffevsa cldfehvqhv fheavrearr
      181 elekspltrp lfiseeralp hqapltarhg lasctfntls tinlkemptv aqaklvtvks
      241 sraqskrkap tltllkgfki f
//
LOCUS       XP_016877785             166 aa            linear   PRI 05-AUG-2025
DEFINITION  ras-like protein family member 12 isoform X2 [Homo sapiens].
ACCESSION   XP_016877785
VERSION     XP_016877785.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022296.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..166
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..166
                     /product="ras-like protein family member 12 isoform X2"
                     /calculated_mol_wt=18199
     Region          22..>144
                     /region_name="P-loop containing Nucleoside Triphosphate
                     Hydrolases"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; cl38936"
                     /db_xref="CDD:476819"
     Site            27..34
                     /site_type="other"
                     /note="G1 box"
                     /db_xref="CDD:206648"
     Site            52
                     /site_type="other"
                     /note="G2 box"
                     /db_xref="CDD:206648"
     Site            55..57
                     /site_type="other"
                     /note="Switch I region"
                     /db_xref="CDD:206648"
     Site            74..77
                     /site_type="other"
                     /note="G3 box"
                     /db_xref="CDD:206648"
     Site            order(76..77,92..93)
                     /site_type="other"
                     /note="Switch II region"
                     /db_xref="CDD:206648"
     Site            134..137
                     /site_type="other"
                     /note="G4 box"
                     /db_xref="CDD:206648"
     CDS             1..166
                     /gene="RASL12"
                     /gene_synonym="RIS"
                     /coded_by="XM_017022296.2:157..657"
                     /db_xref="GeneID:51285"
                     /db_xref="HGNC:HGNC:30289"
ORIGIN      
        1 mssvfgkpra gsgpqsaple vnlailgrrg agksaltvkf ltkrfiseyd pnledtysse
       61 etvdhqpvhl rvmdtadldt prncerylnw ahaflvvysv dsrqsfdsss sylellalha
      121 ketqrsipal llgnkldmaq yrlvlfkvpl dflaivegps ggklsa
//
LOCUS       XP_005254491             151 aa            linear   PRI 05-AUG-2025
DEFINITION  ras-like protein family member 12 isoform X3 [Homo sapiens].
ACCESSION   XP_005254491
VERSION     XP_005254491.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254434.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..151
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..151
                     /product="ras-like protein family member 12 isoform X3"
                     /calculated_mol_wt=16857
     Region          22..>142
                     /region_name="P-loop containing Nucleoside Triphosphate
                     Hydrolases"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; cl38936"
                     /db_xref="CDD:476819"
     Site            27..34
                     /site_type="other"
                     /note="G1 box"
                     /db_xref="CDD:206713"
     Site            52
                     /site_type="other"
                     /note="G2 box"
                     /db_xref="CDD:206713"
     Site            55..57
                     /site_type="other"
                     /note="Switch I region"
                     /db_xref="CDD:206713"
     Site            74..77
                     /site_type="other"
                     /note="G3 box"
                     /db_xref="CDD:206713"
     Site            order(76..77,92..93)
                     /site_type="other"
                     /note="Switch II region"
                     /db_xref="CDD:206713"
     Site            134..137
                     /site_type="other"
                     /note="G4 box"
                     /db_xref="CDD:206713"
     CDS             1..151
                     /gene="RASL12"
                     /gene_synonym="RIS"
                     /coded_by="XM_005254434.5:157..612"
                     /db_xref="GeneID:51285"
                     /db_xref="HGNC:HGNC:30289"
ORIGIN      
        1 mssvfgkpra gsgpqsaple vnlailgrrg agksaltvkf ltkrfiseyd pnledtysse
       61 etvdhqpvhl rvmdtadldt prncerylnw ahaflvvysv dsrqsfdsss sylellalha
      121 ketqrsipal llgnkldmaq yripfrmsyc i
//
LOCUS       XP_016877788            3734 aa            linear   PRI 05-AUG-2025
DEFINITION  spectrin beta chain, non-erythrocytic 5 isoform X1 [Homo sapiens].
ACCESSION   XP_016877788
VERSION     XP_016877788.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022299.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..3734
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..3734
                     /product="spectrin beta chain, non-erythrocytic 5 isoform
                     X1"
                     /calculated_mol_wt=423185
     Region          56..180
                     /region_name="CH_SPTBN5_rpt1"
                     /note="first calponin homology (CH) domain found in
                     spectrin beta chain, non-erythrocytic 5 (SPTBN5) and
                     similar proteins; cd21247"
                     /db_xref="CDD:409096"
     Site            order(57..58,61,64..65,68..69,72..73,76,132,135..136,139,
                     146,150..158,165..166,168..169,172..173,176..177)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409096"
     Region          195..303
                     /region_name="CH_SPTBN5_rpt2"
                     /note="second calponin homology (CH) domain found in
                     spectrin beta chain, non-erythrocytic 5 (SPTBN5) and
                     similar proteins; cd21249"
                     /db_xref="CDD:409098"
     Site            order(199,203,253,255..256,259,266,271..279,288..289,
                     291..292,295..296,299)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409098"
     Region          331..552
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cl02488"
                     /db_xref="CDD:413338"
     Site            order(437..441,450)
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          447..659
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            552..557
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          663..>830
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            764..769
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          769..1019
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            915..920
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1025..1226
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1121..1126
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1229..1438
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1333..1338
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1450..1537
                     /region_name="SPEC"
                     /note="Spectrin repeats; smart00150"
                     /db_xref="CDD:197544"
     Region          1541..1747
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1645..1650
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1648..1855
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1749..1754
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1861..2068
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1962..1967
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          2070..2273
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            2168..2173
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          2277..2490
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            2383..2388
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          2491..2700
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            2595..2600
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          2703..2911
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            2806..2811
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          2914..3107
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            3018..3023
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          3027..3272
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            3164..3169
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          3273..3475
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            3373..3378
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          3483..>3542
                     /region_name="SPEC"
                     /note="Spectrin repeats; smart00150"
                     /db_xref="CDD:197544"
     Region          3596..3696
                     /region_name="PH-like"
                     /note="Pleckstrin homology-like domain; cl17171"
                     /db_xref="CDD:473070"
     CDS             1..3734
                     /gene="SPTBN5"
                     /gene_synonym="BSPECV; HUBSPECV; HUSPECV"
                     /coded_by="XM_017022299.2:1..11205"
                     /db_xref="GeneID:51332"
                     /db_xref="HGNC:HGNC:15680"
                     /db_xref="MIM:605916"
ORIGIN      
        1 mpsrfrepss sssspksagl magqphspre llgaaghrsr rpstelrvpp spsltmdsqy
       61 etghirklqa rhmqmqektf tkwinnvfqc gqagikirnl yteladgihl lrllelisge
      121 alpppsrgrl rvhflenssr alaflrakvp vpligpeniv dgdqtlilgl iwviilrfqi
      181 shisldkeef gasaallstk eallvwcqrk tasytnvnit dfsrswsdgl gfnalihahr
      241 pdlldygslr pdrplhnlaf aflvaeqelg iaqlldpedv aaaqpdersi mtyvslyyhy
      301 csrlhqgqtv qrrltkillq lqetellqtq yeqlvadllr wiaekqmqle ardfpdslpa
      361 mrqllaafti frtqekpprl qqrgaaeall frlqtalqaq nrrpflpheg lglaelsqcw
      421 aglewaeaar sqalqqrllq lqrletlarr fqhkaalres flkdaeqvld qarappasla
      481 tveaavqrlg mleagilpqe grfqalaeia dilrqeqyhs wadvarrqee vtvrwqrllq
      541 hlqgqrkqva dmqavlsllq eveaashqle elqeparsta cgqqlaevve llqrhdllea
      601 qvsahgahvs hlaqqtaeld sslgtsvevl qakartlaql qqslvalvra rralleqtlq
      661 raeflrncee eeawlkecgq rvgnaalgrd lsqiagalqk hkaleaevhr hqavcvdlvr
      721 rgrdlsarrp ptqpdpgera eavqggwqll qtrvvgrgar lqtallvlqy fadaaeaasw
      781 lrerrssler ascgqdqaaa etllrrhvrl ervlrafaae lrrleeqgra asaraslftv
      841 nsalsppges lrnpgpwsea schpgpgdaw kmalpaepdp dfdpntilqt qdhlsqdyes
      901 lralaqlrra rleeamalfg fcsscgelql wlekqtvllq rvqpqadtle vmqlkyenfl
      961 talavgkglw aevsssaeql rqrypgnstq iqrqqeelsq rwgqlealkr ekavqlahsv
     1021 evcsflqecg ptqvqlrdvl lqlealqpgs sedtchalql aqkktlvler rvhflqsvvv
     1081 kveepgyaes qplqgqvetl qgllkqvqeq vaqrarrqae tqarqsflqe sqqlllwaes
     1141 vqaqlrskev svdvasaqrl lrehqdllee ihlwqerlqq ldaqsqpmaa ldcpdsqevp
     1201 ntlrvlgqqg qelkvlweqr qqwlqeglel qkfgrevdgf tatcanhqaw lhldnlgedv
     1261 realsllqqh refgrllstl gpraealrah geklvqsqhp aahtvreqlq siqaqwtrlq
     1321 grseqrrrql laslqlqewk qdvaelmqwm eekglmaahe psgarrnilq tlkrheaaes
     1381 ellatrrhve alqqvgrell srrpcgqedi qtrlqglrsk wealnrkmte rgdelqqagq
     1441 qeqllrqlqd akeqleqleg alqssetgqd lrssqrlqkr hqqlesesrt laakmaalas
     1501 mahgmaaspa ileetqkhlr rlellqghla irglqlqasv elhqfchlsn melswvaehm
     1561 phgsptsyte clngaqslhr khkelqvevk ahqgqvqrvl ssgrslaasg hpqaqhiveq
     1621 cqeleghwae leracearaq clqqavtfqq yfldvseleg wveekrplvs srdygrdeaa
     1681 tlrlinkhqa lqeelaiyws smeeldqtaq tltgpevpeq qrvvqerlre qlralqelaa
     1741 trdrelegtl rlheflreae dlqgwlasqk qaakggeslg edpehalhlc tkfakfqhqv
     1801 emgsqrvaac rllaesller ghsagpmvrq rqqdlqtaws elweltqarg halrdtettl
     1861 rvhrdllevl tqvqekatsl pnnvardlcg leaqlrshqg lerelvgter qlqelletag
     1921 rvqklcpgpq ahavqqrqqa vtqawavlqr rmeqrraqle rarllarfrt avrdyaswaa
     1981 rvrqdlqvee ssqepssgpl klsahqwlra eleareklwq qatqlgqqal laagtptkev
     2041 qeelralqdq rdqvyqtwar kqerlqaeqq eqlflrecgr leeilaaqev slktsalgss
     2101 veeveqlirk hevflkvlta qdkkeaalre rlktlrrprv rdrlpillqr rmrvkelaes
     2161 rghalhasll masftqaatq aedwiqawaq qlkepvppgd lrdklkpllk hqafeaevqa
     2221 heevmtsvak kgeallaqsh pragevsqrl qglrkhwedl rqamalrgqe ledrrnflef
     2281 lqrvdlaeaw iqekevkmnv gdlgqdlehc lqlrrrlref rgnsagdtvg dacirsisdl
     2341 slqlknrdpe evkiicqrrs qlnnrwasfh gnllryqqql egaleihvls reldnvtkri
     2401 qekealiqal dcgkdlesvq rllrkheele revhpiqaqv eslerevgrl cqrspeaahg
     2461 lrhrqqevae swwqlrsraq krrealdalh qaqklqamlq ellvsaqrlr aqmdtspapr
     2521 spvearrmle ehqeckaeld swtdsislar stgqqlltag hpfssdirqv lagleqelss
     2581 legawqehql qlqqalelql flssvekmer wlcskedsla seglwdplap mepllwkhkm
     2641 lewdlevqag kisaleatar glhqgghpea qsalgrcqam llrkealfrq agtrrhrlee
     2701 lrqlqaflqd sqevaawlre knlvaleegl ldtamlpaql qkqqnfqael dasmhqqqel
     2761 qregqrllqg ghpaseaiqe rleelgalwg elqdnsqkkv aklqkaceal rlrrsmeele
     2821 nwlepievel raptvgqalp gvgellgtqr eleaavdkka rqaeallgqa qafvreghcl
     2881 aqdveeqarr llqrfkslre plqerrtale arslllkffr dadeemawvq eklplaaaqd
     2941 ygqslsavrh lqeqhqnles emsshealtr vvlgtgyklv qaghfaahev aarvqqleka
     3001 mahlraeaar rrlllqqaqe aqqfltelle agswlaergh vldsedmghs aeatqallrr
     3061 leatkrdlea fsprierlqq taallesrkn perwaeatps akeqreapyr dgrrllqpgk
     3121 aglqsrlsls shspkvlaql qavreahael lrraearghg lqeqlqlhql eretllldaw
     3181 lttkaataes qdygqdlegv kvleekfdaf rkevqslgqa kvyalrklag tlergaprry
     3241 phiqaqrsri eaawerldqa ikartenlaa ahevhsfqqa aaelqgrmqe ktalmkgedg
     3301 ghslssvrtl qqqhrrlere leamekevar lqteacrlgq lhpaapggla kvqeawatlq
     3361 akaqergqwl aqaaqghafl grcqellawa qerqelasse elaedvagae qllgqheelg
     3421 qeirecrlqa qdlrqegqql vdnshfmsae vteclqeleg rlqeleeawa lrwqrcaesw
     3481 glqklrqrle qaeawlacwe glllkpdygh svsdvelllh rhqdleklla aqeekfaqmq
     3541 ktemeqelll qpqelkpgra gssltsfqwr psghqglgaq laetrdpqda kgtptmegsl
     3601 efkqhllpgg rqpsssswds crgnlqgssl slfldermaa ekvasialld ltgarcerlr
     3661 grhgrkhtfs lrltsgaeil faapseeqae swwralgsta aqslspklka kpvsslnect
     3721 tkdarpgcll rsdp
//
LOCUS       XP_016877791            2793 aa            linear   PRI 05-AUG-2025
DEFINITION  spectrin beta chain, non-erythrocytic 5 isoform X2 [Homo sapiens].
ACCESSION   XP_016877791
VERSION     XP_016877791.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022302.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2793
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2793
                     /product="spectrin beta chain, non-erythrocytic 5 isoform
                     X2"
                     /calculated_mol_wt=317350
     Region          84..285
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            180..185
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          288..497
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            392..397
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          509..596
                     /region_name="SPEC"
                     /note="Spectrin repeats; smart00150"
                     /db_xref="CDD:197544"
     Region          600..806
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            704..709
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          707..914
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            808..813
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          920..1127
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1021..1026
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1129..1332
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1227..1232
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1336..1549
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1442..1447
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1550..1759
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1654..1659
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1762..1970
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1865..1870
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1973..2166
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            2077..2082
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          2086..2331
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            2223..2228
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          2332..2534
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            2432..2437
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          2541..>2601
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cl02488"
                     /db_xref="CDD:413338"
     Region          2655..2755
                     /region_name="PH-like"
                     /note="Pleckstrin homology-like domain; cl17171"
                     /db_xref="CDD:473070"
     CDS             1..2793
                     /gene="SPTBN5"
                     /gene_synonym="BSPECV; HUBSPECV; HUSPECV"
                     /coded_by="XM_017022302.2:90..8471"
                     /db_xref="GeneID:51332"
                     /db_xref="HGNC:HGNC:15680"
                     /db_xref="MIM:605916"
ORIGIN      
        1 mrvcgpwhss agpgwrrpwp csvsavpvgs sscgwrsrqc cskgcsprlt pwrscssnmr
       61 wgqlealkre kavqlahsve vcsflqecgp tqvqlrdvll qlealqpgss edtchalqla
      121 qkktlvlerr vhflqsvvvk veepgyaesq plqgqvetlq gllkqvqeqv aqrarrqaet
      181 qarqsflqes qqlllwaesv qaqlrskevs vdvasaqrll rehqdlleei hlwqerlqql
      241 daqsqpmaal dcpdsqevpn tlrvlgqqgq elkvlweqrq qwlqeglelq kfgrevdgft
      301 atcanhqawl hldnlgedvr ealsllqqhr efgrllstlg praealrahg eklvqsqhpa
      361 ahtvreqlqs iqaqwtrlqg rseqrrrqll aslqlqewkq dvaelmqwme ekglmaahep
      421 sgarrnilqt lkrheaaese llatrrhvea lqqvgrells rrpcgqediq trlqglrskw
      481 ealnrkmter gdelqqagqq eqllrqlqda keqleqlega lqssetgqdl rssqrlqkrh
      541 qqlesesrtl aakmaalasm ahgmaaspai leetqkhlrr lellqghlai rglqlqasve
      601 lhqfchlsnm elswvaehmp hgsptsytec lngaqslhrk hkelqvevka hqgqvqrvls
      661 sgrslaasgh pqaqhiveqc qeleghwael eracearaqc lqqavtfqqy fldvselegw
      721 veekrplvss rdygrdeaat lrlinkhqal qeelaiywss meeldqtaqt ltgpevpeqq
      781 rvvqerlreq lralqelaat rdrelegtlr lheflreaed lqgwlasqkq aakggeslge
      841 dpehalhlct kfakfqhqve mgsqrvaacr llaesllerg hsagpmvrqr qqdlqtawse
      901 lweltqargh alrdtettlr vhrdllevlt qvqekatslp nnvardlcgl eaqlrshqgl
      961 erelvgterq lqelletagr vqklcpgpqa havqqrqqav tqawavlqrr meqrraqler
     1021 arllarfrta vrdyaswaar vrqdlqvees sqepssgplk lsahqwlrae leareklwqq
     1081 atqlgqqall aagtptkevq eelralqdqr dqvyqtwark qerlqaeqqe qlflrecgrl
     1141 eeilaaqevs lktsalgssv eeveqlirkh evflkvltaq dkkeaalrer lktlrrprvr
     1201 drlpillqrr mrvkelaesr ghalhasllm asftqaatqa edwiqawaqq lkepvppgdl
     1261 rdklkpllkh qafeaevqah eevmtsvakk geallaqshp ragevsqrlq glrkhwedlr
     1321 qamalrgqel edrrnflefl qrvdlaeawi qekevkmnvg dlgqdlehcl qlrrrlrefr
     1381 gnsagdtvgd acirsisdls lqlknrdpee vkiicqrrsq lnnrwasfhg nllryqqqle
     1441 galeihvlsr eldnvtkriq ekealiqald cgkdlesvqr llrkheeler evhpiqaqve
     1501 slerevgrlc qrspeaahgl rhrqqevaes wwqlrsraqk rrealdalhq aqklqamlqe
     1561 llvsaqrlra qmdtspaprs pvearrmlee hqeckaelds wtdsislars tgqqlltagh
     1621 pfssdirqvl agleqelssl egawqehqlq lqqalelqlf lssvekmerw lcskedslas
     1681 eglwdplapm epllwkhkml ewdlevqagk isaleatarg lhqgghpeaq salgrcqaml
     1741 lrkealfrqa gtrrhrleel rqlqaflqds qevaawlrek nlvaleegll dtamlpaqlq
     1801 kqqnfqaeld asmhqqqelq regqrllqgg hpaseaiqer leelgalwge lqdnsqkkva
     1861 klqkacealr lrrsmeelen wlepievelr aptvgqalpg vgellgtqre leaavdkkar
     1921 qaeallgqaq afvreghcla qdveeqarrl lqrfkslrep lqerrtalea rslllkffrd
     1981 adeemawvqe klplaaaqdy gqslsavrhl qeqhqnlese msshealtrv vlgtgyklvq
     2041 aghfaaheva arvqqlekam ahlraeaarr rlllqqaqea qqfltellea gswlaerghv
     2101 ldsedmghsa eatqallrrl eatkrdleaf sprierlqqt aallesrknp erwaeatpsa
     2161 keqreapyrd grrllqpgka glqsrlslss hspkvlaqlq avreahaell rraearghgl
     2221 qeqlqlhqle retllldawl ttkaataesq dygqdlegvk vleekfdafr kevqslgqak
     2281 vyalrklagt lergaprryp hiqaqrsrie aawerldqai kartenlaaa hevhsfqqaa
     2341 aelqgrmqek talmkgedgg hslssvrtlq qqhrrlerel eamekevarl qteacrlgql
     2401 hpaapgglak vqeawatlqa kaqergqwla qaaqghaflg rcqellawaq erqelassee
     2461 laedvagaeq llgqheelgq eirecrlqaq dlrqegqqlv dnshfmsaev teclqelegr
     2521 lqeleeawal rwqrcaeswg lqklrqrleq aeawlacweg lllkpdyghs vsdvelllhr
     2581 hqdlekllaa qeekfaqmqk temeqelllq pqelkpgrag ssltsfqwrp sghqglgaql
     2641 aetrdpqdak gtptmegsle fkqhllpggr qpsssswdsc rgnlqgssls lfldermaae
     2701 kvasialldl tgarcerlrg rhgrkhtfsl rltsgaeilf aapseeqaes wwralgstaa
     2761 qslspklkak pvsslnectt kdarpgcllr sdp
//
LOCUS       XP_047288607             479 aa            linear   PRI 05-AUG-2025
DEFINITION  ammonium transporter Rh type C isoform X1 [Homo sapiens].
ACCESSION   XP_047288607
VERSION     XP_047288607.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432651.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..479
                     /product="ammonium transporter Rh type C isoform X1"
                     /calculated_mol_wt=53048
     Region          60..435
                     /region_name="Ammonium_transp"
                     /note="Ammonium Transporter Family; cl03012"
                     /db_xref="CDD:445985"
     CDS             1..479
                     /gene="RHCG"
                     /gene_synonym="C15orf6; PDRC2; RHGK; SLC42A3"
                     /coded_by="XM_047432651.1:40..1479"
                     /db_xref="GeneID:51458"
                     /db_xref="HGNC:HGNC:18140"
                     /db_xref="MIM:605381"
ORIGIN      
        1 mawntnlrwr lpltclllqv imvilfgvfv rydfeadahw wserthknls dmenefyyry
       61 psfqdvhvmv fvgfgflmtf lqrygfsavg fnfllaafgi qwallmqgwf hflqdryivv
      121 gvenlinadf cvasvcvafg avlgkvspiq llimtffqvt lfavnefill nllkvkdagg
      181 smtihtfgay fgltvtrily rrnleqsker qnsvyqsdlf amigtlflwm ywpsfnsais
      241 yhgdsqhraa intycslaac vltsvaissa lhkkgkldmv hiqnatlagg vavgtaaemm
      301 lmpygaliig fvcgiistlg fvyltpfles rlhiqdtcgi nnlhgipgii ggivgavtaa
      361 saslevygke glvhsfdfqg fngdwtartq gkfqiygllv tlamalmggi ivglilrlpf
      421 wgqpsdencf edavywempe gnstvyiped ptfkpsgpsv psvpmvsplp massvplvp
//
LOCUS       XP_006720628             466 aa            linear   PRI 05-AUG-2025
DEFINITION  CTD small phosphatase-like protein 2 isoform X1 [Homo sapiens].
ACCESSION   XP_006720628
VERSION     XP_006720628.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720565.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..466
                     /product="CTD small phosphatase-like protein 2 isoform X1"
                     /calculated_mol_wt=52868
     Region          287..448
                     /region_name="HIF-SF_euk"
                     /note="Dullard-like phosphatase domain; TIGR02251"
                     /db_xref="CDD:274055"
     Site            order(293..297,301..302,348..351,355,388,404..405,
                     407..409)
                     /site_type="active"
                     /db_xref="CDD:319823"
     CDS             1..466
                     /gene="CTDSPL2"
                     /gene_synonym="HSPC058; HSPC129; SCP4"
                     /coded_by="XM_006720565.3:89..1489"
                     /db_xref="GeneID:51496"
                     /db_xref="HGNC:HGNC:26936"
                     /db_xref="MIM:618739"
ORIGIN      
        1 mrlrtrkasq qsnqiqtqrt arakrkysev ddslpsggek psknetglls sikkfikgst
       61 pkeerenpsk rsrierdidn nlitstprag ekpnkqisrv rrksqvngea gsyemtnqhv
      121 kqngklednp ssgspprttl lgtifspvfn ffspankngt sgsdspgqav eaeeivkqld
      181 meqvdeitts tttstngaay snqavqvrps lnngleeaee tvnrdipplt apvtpdsgys
      241 sahaeatyee dwevfdpyyf ikhvppltee qlnrkpalpl ktrstpefsl vldldetlvh
      301 cslneledaa ltfpvlfqdv iyqvyvrlrp ffreflerms qmyeiilfta skkvyadkll
      361 nildpkkqlv rhrlfrehcv cvqgnyikdl nilgrdlskt iiidnspqaf ayqlsngipi
      421 eswfmdkndn ellklipfle klvelnedvr phirdrfrlh dllppd
//
LOCUS       XP_005254498             466 aa            linear   PRI 05-AUG-2025
DEFINITION  CTD small phosphatase-like protein 2 isoform X1 [Homo sapiens].
ACCESSION   XP_005254498
VERSION     XP_005254498.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254441.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..466
                     /product="CTD small phosphatase-like protein 2 isoform X1"
                     /calculated_mol_wt=52868
     Region          287..448
                     /region_name="HIF-SF_euk"
                     /note="Dullard-like phosphatase domain; TIGR02251"
                     /db_xref="CDD:274055"
     Site            order(293..297,301..302,348..351,355,388,404..405,
                     407..409)
                     /site_type="active"
                     /db_xref="CDD:319823"
     CDS             1..466
                     /gene="CTDSPL2"
                     /gene_synonym="HSPC058; HSPC129; SCP4"
                     /coded_by="XM_005254441.3:290..1690"
                     /db_xref="GeneID:51496"
                     /db_xref="HGNC:HGNC:26936"
                     /db_xref="MIM:618739"
ORIGIN      
        1 mrlrtrkasq qsnqiqtqrt arakrkysev ddslpsggek psknetglls sikkfikgst
       61 pkeerenpsk rsrierdidn nlitstprag ekpnkqisrv rrksqvngea gsyemtnqhv
      121 kqngklednp ssgspprttl lgtifspvfn ffspankngt sgsdspgqav eaeeivkqld
      181 meqvdeitts tttstngaay snqavqvrps lnngleeaee tvnrdipplt apvtpdsgys
      241 sahaeatyee dwevfdpyyf ikhvppltee qlnrkpalpl ktrstpefsl vldldetlvh
      301 cslneledaa ltfpvlfqdv iyqvyvrlrp ffreflerms qmyeiilfta skkvyadkll
      361 nildpkkqlv rhrlfrehcv cvqgnyikdl nilgrdlskt iiidnspqaf ayqlsngipi
      421 eswfmdkndn ellklipfle klvelnedvr phirdrfrlh dllppd
//
LOCUS       XP_011519967             465 aa            linear   PRI 05-AUG-2025
DEFINITION  CTD small phosphatase-like protein 2 isoform X2 [Homo sapiens].
ACCESSION   XP_011519967
VERSION     XP_011519967.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521665.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..465
                     /product="CTD small phosphatase-like protein 2 isoform X2"
                     /calculated_mol_wt=52739
     Region          286..447
                     /region_name="HIF-SF_euk"
                     /note="Dullard-like phosphatase domain; TIGR02251"
                     /db_xref="CDD:274055"
     Site            order(292..296,300..301,347..350,354,387,403..404,
                     406..408)
                     /site_type="active"
                     /db_xref="CDD:319823"
     CDS             1..465
                     /gene="CTDSPL2"
                     /gene_synonym="HSPC058; HSPC129; SCP4"
                     /coded_by="XM_011521665.3:169..1566"
                     /db_xref="GeneID:51496"
                     /db_xref="HGNC:HGNC:26936"
                     /db_xref="MIM:618739"
ORIGIN      
        1 mrlrtrkasq qsnqiqtqrt arakrkysev ddslpsggek psknetglls sikkfikgst
       61 pkeerenpsk rsrierdidn nlitstprag ekpnkqisrv rrksqvngag syemtnqhvk
      121 qngklednps sgspprttll gtifspvfnf fspankngts gsdspgqave aeeivkqldm
      181 eqvdeittst ttstngaays nqavqvrpsl nngleeaeet vnrdipplta pvtpdsgyss
      241 ahaeatyeed wevfdpyyfi khvpplteeq lnrkpalplk trstpefslv ldldetlvhc
      301 slneledaal tfpvlfqdvi yqvyvrlrpf freflermsq myeiilftas kkvyadklln
      361 ildpkkqlvr hrlfrehcvc vqgnyikdln ilgrdlskti iidnspqafa yqlsngipie
      421 swfmdkndne llklipflek lvelnedvrp hirdrfrlhd llppd
//
LOCUS       XP_016877795             465 aa            linear   PRI 05-AUG-2025
DEFINITION  CTD small phosphatase-like protein 2 isoform X2 [Homo sapiens].
ACCESSION   XP_016877795
VERSION     XP_016877795.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022306.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..465
                     /product="CTD small phosphatase-like protein 2 isoform X2"
                     /calculated_mol_wt=52739
     Region          286..447
                     /region_name="HIF-SF_euk"
                     /note="Dullard-like phosphatase domain; TIGR02251"
                     /db_xref="CDD:274055"
     Site            order(292..296,300..301,347..350,354,387,403..404,
                     406..408)
                     /site_type="active"
                     /db_xref="CDD:319823"
     CDS             1..465
                     /gene="CTDSPL2"
                     /gene_synonym="HSPC058; HSPC129; SCP4"
                     /coded_by="XM_017022306.3:89..1486"
                     /db_xref="GeneID:51496"
                     /db_xref="HGNC:HGNC:26936"
                     /db_xref="MIM:618739"
ORIGIN      
        1 mrlrtrkasq qsnqiqtqrt arakrkysev ddslpsggek psknetglls sikkfikgst
       61 pkeerenpsk rsrierdidn nlitstprag ekpnkqisrv rrksqvngag syemtnqhvk
      121 qngklednps sgspprttll gtifspvfnf fspankngts gsdspgqave aeeivkqldm
      181 eqvdeittst ttstngaays nqavqvrpsl nngleeaeet vnrdipplta pvtpdsgyss
      241 ahaeatyeed wevfdpyyfi khvpplteeq lnrkpalplk trstpefslv ldldetlvhc
      301 slneledaal tfpvlfqdvi yqvyvrlrpf freflermsq myeiilftas kkvyadklln
      361 ildpkkqlvr hrlfrehcvc vqgnyikdln ilgrdlskti iidnspqafa yqlsngipie
      421 swfmdkndne llklipflek lvelnedvrp hirdrfrlhd llppd
//
LOCUS       XP_047288608             342 aa            linear   PRI 05-AUG-2025
DEFINITION  CTD small phosphatase-like protein 2 isoform X3 [Homo sapiens].
ACCESSION   XP_047288608
VERSION     XP_047288608.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432652.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..342
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..342
                     /product="CTD small phosphatase-like protein 2 isoform X3"
                     /calculated_mol_wt=38005
     Region          287..>323
                     /region_name="Haloacid Dehalogenase-like Hydrolases"
                     /note="The haloacid dehalogenase (HAD) superfamily
                     includes carbon and phosphorus hydrolases such as
                     2-haloalkonoate dehalogenase, epoxide hydrolase,
                     phosphoserine phosphatase, phosphomannomutase,
                     phosphoglycolate phosphatase, P-type ATPase, among others.
                     These...; cl21460"
                     /db_xref="CDD:473868"
     CDS             1..342
                     /gene="CTDSPL2"
                     /gene_synonym="HSPC058; HSPC129; SCP4"
                     /coded_by="XM_047432652.1:169..1197"
                     /db_xref="GeneID:51496"
                     /db_xref="HGNC:HGNC:26936"
                     /db_xref="MIM:618739"
ORIGIN      
        1 mrlrtrkasq qsnqiqtqrt arakrkysev ddslpsggek psknetglls sikkfikgst
       61 pkeerenpsk rsrierdidn nlitstprag ekpnkqisrv rrksqvngea gsyemtnqhv
      121 kqngklednp ssgspprttl lgtifspvfn ffspankngt sgsdspgqav eaeeivkqld
      181 meqvdeitts tttstngaay snqavqvrps lnngleeaee tvnrdipplt apvtpdsgys
      241 sahaeatyee dwevfdpyyf ikhvppltee qlnrkpalpl ktrstpefsl vldldetlvh
      301 cslneledaa ltfpvlfqdv iyqwcclhll akkkytqgse mi
//
LOCUS       XP_047288609             342 aa            linear   PRI 05-AUG-2025
DEFINITION  CTD small phosphatase-like protein 2 isoform X3 [Homo sapiens].
ACCESSION   XP_047288609
VERSION     XP_047288609.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432653.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..342
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..342
                     /product="CTD small phosphatase-like protein 2 isoform X3"
                     /calculated_mol_wt=38005
     Region          287..>323
                     /region_name="Haloacid Dehalogenase-like Hydrolases"
                     /note="The haloacid dehalogenase (HAD) superfamily
                     includes carbon and phosphorus hydrolases such as
                     2-haloalkonoate dehalogenase, epoxide hydrolase,
                     phosphoserine phosphatase, phosphomannomutase,
                     phosphoglycolate phosphatase, P-type ATPase, among others.
                     These...; cl21460"
                     /db_xref="CDD:473868"
     CDS             1..342
                     /gene="CTDSPL2"
                     /gene_synonym="HSPC058; HSPC129; SCP4"
                     /coded_by="XM_047432653.1:89..1117"
                     /db_xref="GeneID:51496"
                     /db_xref="HGNC:HGNC:26936"
                     /db_xref="MIM:618739"
ORIGIN      
        1 mrlrtrkasq qsnqiqtqrt arakrkysev ddslpsggek psknetglls sikkfikgst
       61 pkeerenpsk rsrierdidn nlitstprag ekpnkqisrv rrksqvngea gsyemtnqhv
      121 kqngklednp ssgspprttl lgtifspvfn ffspankngt sgsdspgqav eaeeivkqld
      181 meqvdeitts tttstngaay snqavqvrps lnngleeaee tvnrdipplt apvtpdsgys
      241 sahaeatyee dwevfdpyyf ikhvppltee qlnrkpalpl ktrstpefsl vldldetlvh
      301 cslneledaa ltfpvlfqdv iyqwcclhll akkkytqgse mi
//
LOCUS       XP_047288610             342 aa            linear   PRI 05-AUG-2025
DEFINITION  CTD small phosphatase-like protein 2 isoform X3 [Homo sapiens].
ACCESSION   XP_047288610
VERSION     XP_047288610.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432654.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..342
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..342
                     /product="CTD small phosphatase-like protein 2 isoform X3"
                     /calculated_mol_wt=38005
     Region          287..>323
                     /region_name="Haloacid Dehalogenase-like Hydrolases"
                     /note="The haloacid dehalogenase (HAD) superfamily
                     includes carbon and phosphorus hydrolases such as
                     2-haloalkonoate dehalogenase, epoxide hydrolase,
                     phosphoserine phosphatase, phosphomannomutase,
                     phosphoglycolate phosphatase, P-type ATPase, among others.
                     These...; cl21460"
                     /db_xref="CDD:473868"
     CDS             1..342
                     /gene="CTDSPL2"
                     /gene_synonym="HSPC058; HSPC129; SCP4"
                     /coded_by="XM_047432654.1:169..1197"
                     /db_xref="GeneID:51496"
                     /db_xref="HGNC:HGNC:26936"
                     /db_xref="MIM:618739"
ORIGIN      
        1 mrlrtrkasq qsnqiqtqrt arakrkysev ddslpsggek psknetglls sikkfikgst
       61 pkeerenpsk rsrierdidn nlitstprag ekpnkqisrv rrksqvngea gsyemtnqhv
      121 kqngklednp ssgspprttl lgtifspvfn ffspankngt sgsdspgqav eaeeivkqld
      181 meqvdeitts tttstngaay snqavqvrps lnngleeaee tvnrdipplt apvtpdsgys
      241 sahaeatyee dwevfdpyyf ikhvppltee qlnrkpalpl ktrstpefsl vldldetlvh
      301 cslneledaa ltfpvlfqdv iyqwcclhll akkkytqgse mi
//
LOCUS       XP_047288611             341 aa            linear   PRI 05-AUG-2025
DEFINITION  CTD small phosphatase-like protein 2 isoform X4 [Homo sapiens].
ACCESSION   XP_047288611
VERSION     XP_047288611.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432655.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..341
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..341
                     /product="CTD small phosphatase-like protein 2 isoform X4"
                     /calculated_mol_wt=37876
     Region          286..>322
                     /region_name="Haloacid Dehalogenase-like Hydrolases"
                     /note="The haloacid dehalogenase (HAD) superfamily
                     includes carbon and phosphorus hydrolases such as
                     2-haloalkonoate dehalogenase, epoxide hydrolase,
                     phosphoserine phosphatase, phosphomannomutase,
                     phosphoglycolate phosphatase, P-type ATPase, among others.
                     These...; cl21460"
                     /db_xref="CDD:473868"
     CDS             1..341
                     /gene="CTDSPL2"
                     /gene_synonym="HSPC058; HSPC129; SCP4"
                     /coded_by="XM_047432655.1:169..1194"
                     /db_xref="GeneID:51496"
                     /db_xref="HGNC:HGNC:26936"
                     /db_xref="MIM:618739"
ORIGIN      
        1 mrlrtrkasq qsnqiqtqrt arakrkysev ddslpsggek psknetglls sikkfikgst
       61 pkeerenpsk rsrierdidn nlitstprag ekpnkqisrv rrksqvngag syemtnqhvk
      121 qngklednps sgspprttll gtifspvfnf fspankngts gsdspgqave aeeivkqldm
      181 eqvdeittst ttstngaays nqavqvrpsl nngleeaeet vnrdipplta pvtpdsgyss
      241 ahaeatyeed wevfdpyyfi khvpplteeq lnrkpalplk trstpefslv ldldetlvhc
      301 slneledaal tfpvlfqdvi yqwcclhlla kkkytqgsem i
//
LOCUS       XP_047288612             757 aa            linear   PRI 05-AUG-2025
DEFINITION  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic
            phosphodiesterase 8A isoform X1 [Homo sapiens].
ACCESSION   XP_047288612
VERSION     XP_047288612.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432656.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..757
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..757
                     /product="high affinity cAMP-specific and IBMX-insensitive
                     3',5'-cyclic phosphodiesterase 8A isoform X1"
                     /calculated_mol_wt=85918
     Region          1..>97
                     /region_name="RpfG"
                     /note="Response regulator c-di-GMP phosphodiesterase, RpfG
                     family, contains REC and HD-GYP domains [Signal
                     transduction mechanisms]; COG3437"
                     /db_xref="CDD:442663"
     Region          147..>252
                     /region_name="PAS"
                     /note="PAS domain [Signal transduction mechanisms];
                     COG2202"
                     /db_xref="CDD:441804"
     Region          483..734
                     /region_name="PDEase_I"
                     /note="3'5'-cyclic nucleotide phosphodiesterase;
                     pfam00233"
                     /db_xref="CDD:459723"
     CDS             1..757
                     /gene="PDE8A"
                     /gene_synonym="HsT19550"
                     /coded_by="XM_047432656.1:50..2323"
                     /db_xref="GeneID:5151"
                     /db_xref="HGNC:HGNC:8793"
                     /db_xref="MIM:602972"
ORIGIN      
        1 mrfhqdqlqv llvftkednq cngfcracek agfkctvtke aqavlacfld khhdiiiidh
       61 rnprqldaea lcrsirsskl sentvivgvv rrvdreelsv mpfisagftr ryvenpnima
      121 cynellqlef gevrsqlklr acnsvftale nsedaieits edrfiqyanp afettmgyqs
      181 geligkelge vpinekkadl ldtinsciri gkewqgiyya kkkngdniqq nvkiipvigq
      241 ggkirhyvsi irvcngnnka ekisecvqsd thtdnqtgkh kdrrkgsldv kavasratev
      301 ssqrrhssma rihsmtieap itkviniina aqesspmpvt ealdrvleil rttelyspqf
      361 gakdddphan dlvgglmsdg lrrlsgneyv lstkntqmvs sniitpisld dvppriaram
      421 eneeywdfdi feleaathnr pliylglkmf arfgiceflh csestlrswl qiieanyhss
      481 npyhnsthsa dvlhatayfl skeriketld pidevaalia atihdvdhpg rtnsflcnag
      541 selailyndt avleshhaal afqlttgddk cnifknmern dyrtlrqgii dmvlatemtk
      601 hfehvnkfvn sinkplatle engetdknqe vintmlrtpe nrtlikrmli kcadvsnpcr
      661 plqyciewaa riseeyfsqt deekqqglpv vmpvfdrntc sipksqisfi dyfitdmfda
      721 wdafvdlpdl mqhldnnfky wkgldemklr nlrpppe
//
LOCUS       XP_047288613             711 aa            linear   PRI 05-AUG-2025
DEFINITION  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic
            phosphodiesterase 8A isoform X2 [Homo sapiens].
ACCESSION   XP_047288613
VERSION     XP_047288613.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432657.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..711
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..711
                     /product="high affinity cAMP-specific and IBMX-insensitive
                     3',5'-cyclic phosphodiesterase 8A isoform X2"
                     /calculated_mol_wt=80907
     Region          1..>97
                     /region_name="RpfG"
                     /note="Response regulator c-di-GMP phosphodiesterase, RpfG
                     family, contains REC and HD-GYP domains [Signal
                     transduction mechanisms]; COG3437"
                     /db_xref="CDD:442663"
     Region          437..688
                     /region_name="PDEase_I"
                     /note="3'5'-cyclic nucleotide phosphodiesterase;
                     pfam00233"
                     /db_xref="CDD:459723"
     CDS             1..711
                     /gene="PDE8A"
                     /gene_synonym="HsT19550"
                     /coded_by="XM_047432657.1:250..2385"
                     /db_xref="GeneID:5151"
                     /db_xref="HGNC:HGNC:8793"
                     /db_xref="MIM:602972"
ORIGIN      
        1 mrfhqdqlqv llvftkednq cngfcracek agfkctvtke aqavlacfld khhdiiiidh
       61 rnprqldaea lcrsirsskl sentvivgvv rrvdreelsv mpfisagftr ryvenpnima
      121 cynellqlef gevrsqlklr acnsvftale nsedaieits edrfiqewqg iyyakkkngd
      181 niqqnvkiip vigqggkirh yvsiirvcng nnkaekisec vqsdthtdnq tgkhkdrrkg
      241 sldvkavasr atevssqrrh ssmarihsmt ieapitkvin iinaaqessp mpvtealdrv
      301 leilrttely spqfgakddd phandlvggl msdglrrlsg neyvlstknt qmvssniitp
      361 islddvppri arameneeyw dfdifeleaa thnrpliylg lkmfarfgic eflhcsestl
      421 rswlqiiean yhssnpyhns thsadvlhat ayflskerik etldpideva aliaatihdv
      481 dhpgrtnsfl cnagselail yndtavlesh haalafqltt gddkcnifkn merndyrtlr
      541 qgiidmvlat emtkhfehvn kfvnsinkpl atleengetd knqevintml rtpenrtlik
      601 rmlikcadvs npcrplqyci ewaariseey fsqtdeekqq glpvvmpvfd rntcsipksq
      661 isfidyfitd mfdawdafvd lpdlmqhldn nfkywkglde mklrnlrppp e
//
LOCUS       XP_047288614             639 aa            linear   PRI 05-AUG-2025
DEFINITION  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic
            phosphodiesterase 8A isoform X3 [Homo sapiens].
ACCESSION   XP_047288614
VERSION     XP_047288614.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432658.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..639
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..639
                     /product="high affinity cAMP-specific and IBMX-insensitive
                     3',5'-cyclic phosphodiesterase 8A isoform X3"
                     /calculated_mol_wt=72385
     Region          29..>134
                     /region_name="PAS"
                     /note="PAS domain [Signal transduction mechanisms];
                     COG2202"
                     /db_xref="CDD:441804"
     Region          365..616
                     /region_name="PDEase_I"
                     /note="3'5'-cyclic nucleotide phosphodiesterase;
                     pfam00233"
                     /db_xref="CDD:459723"
     CDS             1..639
                     /gene="PDE8A"
                     /gene_synonym="HsT19550"
                     /coded_by="XM_047432658.1:115..2034"
                     /db_xref="GeneID:5151"
                     /db_xref="HGNC:HGNC:8793"
                     /db_xref="MIM:602972"
ORIGIN      
        1 macynellql efgevrsqlk lracnsvfta lensedaiei tsedrfiqya npafettmgy
       61 qsgeligkel gevpinekka dlldtinsci rigkewqgiy yakkkngdni qqnvkiipvi
      121 gqggkirhyv siirvcngnn kaekisecvq sdthtdnqtg khkdrrkgsl dvkavasrat
      181 evssqrrhss marihsmtie apitkvinii naaqesspmp vtealdrvle ilrttelysp
      241 qfgakdddph andlvgglms dglrrlsgne yvlstkntqm vssniitpis lddvppriar
      301 ameneeywdf difeleaath nrpliylglk mfarfgicef lhcsestlrs wlqiieanyh
      361 ssnpyhnsth sadvlhatay flskeriket ldpidevaal iaatihdvdh pgrtnsflcn
      421 agselailyn dtavleshha alafqlttgd dkcnifknme rndyrtlrqg iidmvlatem
      481 tkhfehvnkf vnsinkplat leengetdkn qevintmlrt penrtlikrm likcadvsnp
      541 crplqyciew aariseeyfs qtdeekqqgl pvvmpvfdrn tcsipksqis fidyfitdmf
      601 dawdafvdlp dlmqhldnnf kywkgldemk lrnlrpppe
//
LOCUS       XP_016877799             596 aa            linear   PRI 05-AUG-2025
DEFINITION  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic
            phosphodiesterase 8A isoform X4 [Homo sapiens].
ACCESSION   XP_016877799
VERSION     XP_016877799.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022310.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..596
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..596
                     /product="high affinity cAMP-specific and IBMX-insensitive
                     3',5'-cyclic phosphodiesterase 8A isoform X4"
                     /calculated_mol_wt=66367
     Region          73..>169
                     /region_name="RpfG"
                     /note="Response regulator c-di-GMP phosphodiesterase, RpfG
                     family, contains REC and HD-GYP domains [Signal
                     transduction mechanisms]; COG3437"
                     /db_xref="CDD:442663"
     Region          219..>324
                     /region_name="PAS"
                     /note="PAS domain [Signal transduction mechanisms];
                     COG2202"
                     /db_xref="CDD:441804"
     Region          555..>580
                     /region_name="PDEase_I"
                     /note="3'5'-cyclic nucleotide phosphodiesterase;
                     pfam00233"
                     /db_xref="CDD:459723"
     CDS             1..596
                     /gene="PDE8A"
                     /gene_synonym="HsT19550"
                     /coded_by="XM_017022310.3:308..2098"
                     /db_xref="GeneID:5151"
                     /db_xref="HGNC:HGNC:8793"
                     /db_xref="MIM:602972"
ORIGIN      
        1 mgcapsihis erlvaedaps paapplssgg prlpqgqkta alprtrgagl leselrdgsg
       61 kkvavadvqf gpmrfhqdql qvllvftked nqcngfcrac ekagfkctvt keaqavlacf
      121 ldkhhdiiii dhrnprqlda ealcrsirss klsentvivg vvrrvdreel svmpfisagf
      181 trryvenpni macynellql efgevrsqlk lracnsvfta lensedaiei tsedrfiqya
      241 npafettmgy qsgeligkel gevpinekka dlldtinsci rigkewqgiy yakkkngdni
      301 qqnvkiipvi gqggkirhyv siirvcngnn kaekisecvq sdthtdnqtg khkdrrkgsl
      361 dvkavasrat evssqrrhss marihsmtie apitkvinii naaqesspmp vtealdrvle
      421 ilrttelysp qfgakdddph andlvgglms dglrrlsgne yvlstkntqm vssniitpis
      481 lddvppriar ameneeywdf difeleaath nrpliylglk mfarfgicef lhcsestlrs
      541 wlqiieanyh ssnpyhnsth sadvlhatay flskeriksl ekdgklpdhf vkltkl
//
LOCUS       XP_047288615             582 aa            linear   PRI 05-AUG-2025
DEFINITION  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic
            phosphodiesterase 8A isoform X5 [Homo sapiens].
ACCESSION   XP_047288615
VERSION     XP_047288615.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432659.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..582
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..582
                     /product="high affinity cAMP-specific and IBMX-insensitive
                     3',5'-cyclic phosphodiesterase 8A isoform X5"
                     /calculated_mol_wt=65882
     Region          2..>77
                     /region_name="PAS"
                     /note="PAS domain [Signal transduction mechanisms];
                     COG2202"
                     /db_xref="CDD:441804"
     Region          308..559
                     /region_name="PDEase_I"
                     /note="3'5'-cyclic nucleotide phosphodiesterase;
                     pfam00233"
                     /db_xref="CDD:459723"
     CDS             1..582
                     /gene="PDE8A"
                     /gene_synonym="HsT19550"
                     /coded_by="XM_047432659.1:119..1867"
                     /db_xref="GeneID:5151"
                     /db_xref="HGNC:HGNC:8793"
                     /db_xref="MIM:602972"
ORIGIN      
        1 mgyqsgelig kelgevpine kkadlldtin scirigkewq giyyakkkng dniqqnvkii
       61 pvigqggkir hyvsiirvcn gnnkaekise cvqsdthtdn qtgkhkdrrk gsldvkavas
      121 ratevssqrr hssmarihsm tieapitkvi niinaaqess pmpvtealdr vleilrttel
      181 yspqfgakdd dphandlvgg lmsdglrrls gneyvlstkn tqmvssniit pislddvppr
      241 iarameneey wdfdifelea athnrpliyl glkmfarfgi ceflhcsest lrswlqiiea
      301 nyhssnpyhn sthsadvlha tayflskeri ketldpidev aaliaatihd vdhpgrtnsf
      361 lcnagselai lyndtavles hhaalafqlt tgddkcnifk nmerndyrtl rqgiidmvla
      421 temtkhfehv nkfvnsinkp latleenget dknqevintm lrtpenrtli krmlikcadv
      481 snpcrplqyc iewaarisee yfsqtdeekq qglpvvmpvf drntcsipks qisfidyfit
      541 dmfdawdafv dlpdlmqhld nnfkywkgld emklrnlrpp pe
//
LOCUS       XP_011519970             571 aa            linear   PRI 05-AUG-2025
DEFINITION  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic
            phosphodiesterase 8A isoform X6 [Homo sapiens].
ACCESSION   XP_011519970
VERSION     XP_011519970.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521668.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..571
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..571
                     /product="high affinity cAMP-specific and IBMX-insensitive
                     3',5'-cyclic phosphodiesterase 8A isoform X6"
                     /calculated_mol_wt=64836
     Region          297..548
                     /region_name="PDEase_I"
                     /note="3'5'-cyclic nucleotide phosphodiesterase;
                     pfam00233"
                     /db_xref="CDD:459723"
     CDS             1..571
                     /gene="PDE8A"
                     /gene_synonym="HsT19550"
                     /coded_by="XM_011521668.3:717..2432"
                     /db_xref="GeneID:5151"
                     /db_xref="HGNC:HGNC:8793"
                     /db_xref="MIM:602972"
ORIGIN      
        1 mglvhldvae lplrhsmsls lrrqveewqg iyyakkkngd niqqnvkiip vigqggkirh
       61 yvsiirvcng nnkaekisec vqsdthtdnq tgkhkdrrkg sldvkavasr atevssqrrh
      121 ssmarihsmt ieapitkvin iinaaqessp mpvtealdrv leilrttely spqfgakddd
      181 phandlvggl msdglrrlsg neyvlstknt qmvssniitp islddvppri arameneeyw
      241 dfdifeleaa thnrpliylg lkmfarfgic eflhcsestl rswlqiiean yhssnpyhns
      301 thsadvlhat ayflskerik etldpideva aliaatihdv dhpgrtnsfl cnagselail
      361 yndtavlesh haalafqltt gddkcnifkn merndyrtlr qgiidmvlat emtkhfehvn
      421 kfvnsinkpl atleengetd knqevintml rtpenrtlik rmlikcadvs npcrplqyci
      481 ewaariseey fsqtdeekqq glpvvmpvfd rntcsipksq isfidyfitd mfdawdafvd
      541 lpdlmqhldn nfkywkglde mklrnlrppp e
//
LOCUS       XP_047288616             449 aa            linear   PRI 05-AUG-2025
DEFINITION  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic
            phosphodiesterase 8A isoform X7 [Homo sapiens].
ACCESSION   XP_047288616
VERSION     XP_047288616.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432660.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..449
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..449
                     /product="high affinity cAMP-specific and IBMX-insensitive
                     3',5'-cyclic phosphodiesterase 8A isoform X7"
                     /calculated_mol_wt=51123
     Region          175..426
                     /region_name="PDEase_I"
                     /note="3'5'-cyclic nucleotide phosphodiesterase;
                     pfam00233"
                     /db_xref="CDD:459723"
     CDS             1..449
                     /gene="PDE8A"
                     /gene_synonym="HsT19550"
                     /coded_by="XM_047432660.1:318..1667"
                     /db_xref="GeneID:5151"
                     /db_xref="HGNC:HGNC:8793"
                     /db_xref="MIM:602972"
ORIGIN      
        1 marihsmtie apitkvinii naaqesspmp vtealdrvle ilrttelysp qfgakdddph
       61 andlvgglms dglrrlsgne yvlstkntqm vssniitpis lddvppriar ameneeywdf
      121 difeleaath nrpliylglk mfarfgicef lhcsestlrs wlqiieanyh ssnpyhnsth
      181 sadvlhatay flskeriket ldpidevaal iaatihdvdh pgrtnsflcn agselailyn
      241 dtavleshha alafqlttgd dkcnifknme rndyrtlrqg iidmvlatem tkhfehvnkf
      301 vnsinkplat leengetdkn qevintmlrt penrtlikrm likcadvsnp crplqyciew
      361 aariseeyfs qtdeekqqgl pvvmpvfdrn tcsipksqis fidyfitdmf dawdafvdlp
      421 dlmqhldnnf kywkgldemk lrnlrpppe
//
LOCUS       XP_047288617             403 aa            linear   PRI 05-AUG-2025
DEFINITION  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic
            phosphodiesterase 8A isoform X8 [Homo sapiens].
ACCESSION   XP_047288617
VERSION     XP_047288617.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432661.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..403
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..403
                     /product="high affinity cAMP-specific and IBMX-insensitive
                     3',5'-cyclic phosphodiesterase 8A isoform X8"
                     /calculated_mol_wt=44606
     Region          73..>169
                     /region_name="RpfG"
                     /note="Response regulator c-di-GMP phosphodiesterase, RpfG
                     family, contains REC and HD-GYP domains [Signal
                     transduction mechanisms]; COG3437"
                     /db_xref="CDD:442663"
     Region          219..>324
                     /region_name="PAS"
                     /note="PAS domain [Signal transduction mechanisms];
                     COG2202"
                     /db_xref="CDD:441804"
     CDS             1..403
                     /gene="PDE8A"
                     /gene_synonym="HsT19550"
                     /coded_by="XM_047432661.1:308..1519"
                     /db_xref="GeneID:5151"
                     /db_xref="HGNC:HGNC:8793"
                     /db_xref="MIM:602972"
ORIGIN      
        1 mgcapsihis erlvaedaps paapplssgg prlpqgqkta alprtrgagl leselrdgsg
       61 kkvavadvqf gpmrfhqdql qvllvftked nqcngfcrac ekagfkctvt keaqavlacf
      121 ldkhhdiiii dhrnprqlda ealcrsirss klsentvivg vvrrvdreel svmpfisagf
      181 trryvenpni macynellql efgevrsqlk lracnsvfta lensedaiei tsedrfiqya
      241 npafettmgy qsgeligkel gevpinekka dlldtinsci rigkewqgiy yakkkngdni
      301 qqnvkiipvi gqggkirhyv siirvcngnn kaekisecvq sdthtdnqtg khkdrrkgsl
      361 dvkavasrat evssqrrhss marihsmtie apitktlkwf qai
//
LOCUS       XP_016877801             126 aa            linear   PRI 05-AUG-2025
DEFINITION  ras-related protein Rab-8B isoform X1 [Homo sapiens].
ACCESSION   XP_016877801
VERSION     XP_016877801.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022312.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..126
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..126
                     /product="ras-related protein Rab-8B isoform X1"
                     /calculated_mol_wt=14173
     Region          <1..91
                     /region_name="P-loop containing Nucleoside Triphosphate
                     Hydrolases"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; cl38936"
                     /db_xref="CDD:476819"
     Site            40..43
                     /site_type="other"
                     /note="G4 box"
                     /db_xref="CDD:206659"
     Site            70..72
                     /site_type="other"
                     /note="G5 box"
                     /db_xref="CDD:206659"
     CDS             1..126
                     /gene="RAB8B"
                     /coded_by="XM_017022312.1:395..775"
                     /db_xref="GeneID:51762"
                     /db_xref="HGNC:HGNC:30273"
                     /db_xref="MIM:613532"
ORIGIN      
        1 mgimlvydit neksfdnikn wirnieehas sdvermilgn kcdmndkrqv skergeklai
       61 dygikflets akssanveea fftlardimt klnrkmndsn sagaggpvki tenrskktsf
      121 frcsll
//
LOCUS       XP_011519971             122 aa            linear   PRI 05-AUG-2025
DEFINITION  ras-related protein Rab-8B isoform X2 [Homo sapiens].
ACCESSION   XP_011519971
VERSION     XP_011519971.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521669.4
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 1% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..122
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..122
                     /product="ras-related protein Rab-8B isoform X2"
                     /calculated_mol_wt=14024
     Region          6..>82
                     /region_name="P-loop containing Nucleoside Triphosphate
                     Hydrolases"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; cl38936"
                     /db_xref="CDD:476819"
     Site            15..22
                     /site_type="other"
                     /note="G1 box"
                     /db_xref="CDD:206659"
     Site            40
                     /site_type="other"
                     /note="G2 box"
                     /db_xref="CDD:206659"
     Site            44..46
                     /site_type="other"
                     /note="Switch I region"
                     /db_xref="CDD:206659"
     Site            63..66
                     /site_type="other"
                     /note="G3 box"
                     /db_xref="CDD:206659"
     CDS             1..122
                     /gene="RAB8B"
                     /coded_by="XM_011521669.4:20..388"
                     /db_xref="GeneID:51762"
                     /db_xref="HGNC:HGNC:30273"
                     /db_xref="MIM:613532"
ORIGIN      
        1 maktydylfk llligdsgvg ktcllfrfse dafnttfist igidfkirti eldgkkiklq
       61 iwdtagqerf rtittayyrg ampchhyllp hhlhnihccg sspchppdhh saswperiwk
      121 ef
//
LOCUS       XP_047288618             609 aa            linear   PRI 05-AUG-2025
DEFINITION  pyruvate kinase PKM isoform X1 [Homo sapiens].
ACCESSION   XP_047288618
VERSION     XP_047288618.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432662.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..609
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..609
                     /product="pyruvate kinase PKM isoform X1"
                     /calculated_mol_wt=66389
     Region          120..608
                     /region_name="Pyruvate_Kinase"
                     /note="Pyruvate kinase (PK): Large allosteric enzyme that
                     regulates glycolysis through binding of the substrate,
                     phosphoenolpyruvate, and one or more allosteric effectors.
                     Like other allosteric enzymes, PK has a high substrate
                     affinity R state and a low...; cd00288"
                     /db_xref="CDD:238178"
     Site            order(122..123,185,187,195..198,287..288,294,297..301,316,
                     324,331,342,378,396..397,401,433,435,464,466..467,521,523,
                     525,536,539..540,542,544..546)
                     /site_type="active"
                     /note="domain interfaces [active]"
                     /db_xref="CDD:238178"
     Site            order(151,153,191,322,348,350,374,406)
                     /site_type="active"
                     /db_xref="CDD:238178"
     CDS             1..609
                     /gene="PKM"
                     /gene_synonym="CTHBP; HEL-S-30; OIP3; p58; PK3; PKM2; TCB;
                     THBP1"
                     /coded_by="XM_047432662.1:19..1848"
                     /db_xref="GeneID:5315"
                     /db_xref="HGNC:HGNC:9021"
                     /db_xref="MIM:179050"
ORIGIN      
        1 mrerslsqks alrnqgwaal lepgessecf tynssspght vfssersllv rprshpepkg
       61 ehyvtgsptp enqrtsaams kphseagtaf iqtqqlhaam adtflehmcr ldidsppita
      121 rntgiictig pasrsvetlk emiksgmnva rlnfshgthe yhaetiknvr tatesfasdp
      181 ilyrpvaval dtkgpeirtg likgsgtaev elkkgatlki tldnaymekc denilwldyk
      241 nickvvevgs kiyvddglis lqvkqkgadf lvtevenggs lgskkgvnlp gaavdlpavs
      301 ekdiqdlkfg veqdvdmvfa sfirkasdvh evrkvlgekg knikiiskie nhegvrrfde
      361 ileasdgimv argdlgieip aekvflaqkm migrcnragk pvicatqmle smikkprptr
      421 aegsdvanav ldgadcimls getakgdypl eavrmqhlia reaeaaiyhl qlfeelrrla
      481 pitsdpteat avgaveasfk ccsgaiivlt ksgrsahqva ryrprapiia vtrnpqtarq
      541 ahlyrgifpv lckdpvqeaw aedvdlrvnf amnvgkargf fkkgdvvivl tgwrpgsgft
      601 ntmrvvpvp
//
LOCUS       XP_047288619             609 aa            linear   PRI 05-AUG-2025
DEFINITION  pyruvate kinase PKM isoform X2 [Homo sapiens].
ACCESSION   XP_047288619
VERSION     XP_047288619.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432663.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..609
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..609
                     /product="pyruvate kinase PKM isoform X2"
                     /calculated_mol_wt=66515
     Region          120..608
                     /region_name="Pyruvate_Kinase"
                     /note="Pyruvate kinase (PK): Large allosteric enzyme that
                     regulates glycolysis through binding of the substrate,
                     phosphoenolpyruvate, and one or more allosteric effectors.
                     Like other allosteric enzymes, PK has a high substrate
                     affinity R state and a low...; cd00288"
                     /db_xref="CDD:238178"
     Site            order(122..123,185,187,195..198,287..288,294,297..301,316,
                     324,331,342,378,396..397,401,433,435,464,466..467,521,523,
                     525,536,539..540,542,544..546)
                     /site_type="active"
                     /note="domain interfaces [active]"
                     /db_xref="CDD:238178"
     Site            order(151,153,191,322,348,350,374,406)
                     /site_type="active"
                     /db_xref="CDD:238178"
     CDS             1..609
                     /gene="PKM"
                     /gene_synonym="CTHBP; HEL-S-30; OIP3; p58; PK3; PKM2; TCB;
                     THBP1"
                     /coded_by="XM_047432663.1:19..1848"
                     /db_xref="GeneID:5315"
                     /db_xref="HGNC:HGNC:9021"
                     /db_xref="MIM:179050"
ORIGIN      
        1 mrerslsqks alrnqgwaal lepgessecf tynssspght vfssersllv rprshpepkg
       61 ehyvtgsptp enqrtsaams kphseagtaf iqtqqlhaam adtflehmcr ldidsppita
      121 rntgiictig pasrsvetlk emiksgmnva rlnfshgthe yhaetiknvr tatesfasdp
      181 ilyrpvaval dtkgpeirtg likgsgtaev elkkgatlki tldnaymekc denilwldyk
      241 nickvvevgs kiyvddglis lqvkqkgadf lvtevenggs lgskkgvnlp gaavdlpavs
      301 ekdiqdlkfg veqdvdmvfa sfirkasdvh evrkvlgekg knikiiskie nhegvrrfde
      361 ileasdgimv argdlgieip aekvflaqkm migrcnragk pvicatqmle smikkprptr
      421 aegsdvanav ldgadcimls getakgdypl eavrmqhlia reaeaamfhr klfeelvras
      481 shstdlmeam amgsveasyk claaalivlt esgrsahqva ryrprapiia vtrnpqtarq
      541 ahlyrgifpv lckdpvqeaw aedvdlrvnf amnvgkargf fkkgdvvivl tgwrpgsgft
      601 ntmrvvpvp
//
LOCUS       XP_005254500             591 aa            linear   PRI 05-AUG-2025
DEFINITION  pyruvate kinase PKM isoform X3 [Homo sapiens].
ACCESSION   XP_005254500
VERSION     XP_005254500.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254443.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..591
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..591
                     /product="pyruvate kinase PKM isoform X3"
                     /calculated_mol_wt=64447
     Region          102..590
                     /region_name="Pyruvate_Kinase"
                     /note="Pyruvate kinase (PK): Large allosteric enzyme that
                     regulates glycolysis through binding of the substrate,
                     phosphoenolpyruvate, and one or more allosteric effectors.
                     Like other allosteric enzymes, PK has a high substrate
                     affinity R state and a low...; cd00288"
                     /db_xref="CDD:238178"
     Site            order(104..105,167,169,177..180,269..270,276,279..283,298,
                     306,313,324,360,378..379,383,415,417,446,448..449,503,505,
                     507,518,521..522,524,526..528)
                     /site_type="active"
                     /note="domain interfaces [active]"
                     /db_xref="CDD:238178"
     Site            order(133,135,173,304,330,332,356,388)
                     /site_type="active"
                     /db_xref="CDD:238178"
     CDS             1..591
                     /gene="PKM"
                     /gene_synonym="CTHBP; HEL-S-30; OIP3; p58; PK3; PKM2; TCB;
                     THBP1"
                     /coded_by="XM_005254443.2:2258..4033"
                     /db_xref="GeneID:5315"
                     /db_xref="HGNC:HGNC:9021"
                     /db_xref="MIM:179050"
ORIGIN      
        1 mtqpfnysaf eriifagspg htvfssersl lvrprshpep kgehyvtgsp tpenqrtsaa
       61 mskphseagt afiqtqqlha amadtflehm crldidsppi tarntgiict igpasrsvet
      121 lkemiksgmn varlnfshgt heyhaetikn vrtatesfas dpilyrpvav aldtkgpeir
      181 tglikgsgta evelkkgatl kitldnayme kcdenilwld yknickvvev gskiyvddgl
      241 islqvkqkga dflvteveng gslgskkgvn lpgaavdlpa vsekdiqdlk fgveqdvdmv
      301 fasfirkasd vhevrkvlge kgknikiisk ienhegvrrf deileasdgi mvargdlgie
      361 ipaekvflaq kmmigrcnra gkpvicatqm lesmikkprp traegsdvan avldgadcim
      421 lsgetakgdy pleavrmqhl iareaeaaiy hlqlfeelrr lapitsdpte atavgaveas
      481 fkccsgaiiv ltksgrsahq varyrprapi iavtrnpqta rqahlyrgif pvlckdpvqe
      541 awaedvdlrv nfamnvgkar gffkkgdvvi vltgwrpgsg ftntmrvvpv p
//
LOCUS       XP_011519972             566 aa            linear   PRI 05-AUG-2025
DEFINITION  pyruvate kinase PKM isoform X4 [Homo sapiens].
ACCESSION   XP_011519972
VERSION     XP_011519972.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521670.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..566
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..566
                     /product="pyruvate kinase PKM isoform X4"
                     /calculated_mol_wt=61338
     Region          77..565
                     /region_name="Pyruvate_Kinase"
                     /note="Pyruvate kinase (PK): Large allosteric enzyme that
                     regulates glycolysis through binding of the substrate,
                     phosphoenolpyruvate, and one or more allosteric effectors.
                     Like other allosteric enzymes, PK has a high substrate
                     affinity R state and a low...; cd00288"
                     /db_xref="CDD:238178"
     Site            order(79..80,142,144,152..155,244..245,251,254..258,273,
                     281,288,299,335,353..354,358,390,392,421,423..424,478,480,
                     482,493,496..497,499,501..503)
                     /site_type="active"
                     /note="domain interfaces [active]"
                     /db_xref="CDD:238178"
     Site            order(108,110,148,279,305,307,331,363)
                     /site_type="active"
                     /db_xref="CDD:238178"
     CDS             1..566
                     /gene="PKM"
                     /gene_synonym="CTHBP; HEL-S-30; OIP3; p58; PK3; PKM2; TCB;
                     THBP1"
                     /coded_by="XM_011521670.2:204..1904"
                     /db_xref="GeneID:5315"
                     /db_xref="HGNC:HGNC:9021"
                     /db_xref="MIM:179050"
ORIGIN      
        1 mqwsserger lltpgacsse vpsavpsrsg gtsaamskph seagtafiqt qqlhaamadt
       61 flehmcrldi dsppitarnt giictigpas rsvetlkemi ksgmnvarln fshgtheyha
      121 etiknvrtat esfasdpily rpvavaldtk gpeirtglik gsgtaevelk kgatlkitld
      181 naymekcden ilwldyknic kvvevgskiy vddglislqv kqkgadflvt evenggslgs
      241 kkgvnlpgaa vdlpavsekd iqdlkfgveq dvdmvfasfi rkasdvhevr kvlgekgkni
      301 kiiskienhe gvrrfdeile asdgimvarg dlgieipaek vflaqkmmig rcnragkpvi
      361 catqmlesmi kkprptraeg sdvanavldg adcimlsget akgdypleav rmqhliarea
      421 eaaiyhlqlf eelrrlapit sdpteatavg aveasfkccs gaiivltksg rsahqvaryr
      481 prapiiavtr npqtarqahl yrgifpvlck dpvqeawaed vdlrvnfamn vgkargffkk
      541 gdvvivltgw rpgsgftntm rvvpvp
//
LOCUS       XP_047288620             552 aa            linear   PRI 05-AUG-2025
DEFINITION  pyruvate kinase PKM isoform X5 [Homo sapiens].
ACCESSION   XP_047288620
VERSION     XP_047288620.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432664.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..552
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..552
                     /product="pyruvate kinase PKM isoform X5"
                     /calculated_mol_wt=60111
     Region          63..551
                     /region_name="Pyruvate_Kinase"
                     /note="Pyruvate kinase (PK): Large allosteric enzyme that
                     regulates glycolysis through binding of the substrate,
                     phosphoenolpyruvate, and one or more allosteric effectors.
                     Like other allosteric enzymes, PK has a high substrate
                     affinity R state and a low...; cd00288"
                     /db_xref="CDD:238178"
     Site            order(65..66,128,130,138..141,230..231,237,240..244,259,
                     267,274,285,321,339..340,344,376,378,407,409..410,464,466,
                     468,479,482..483,485,487..489)
                     /site_type="active"
                     /note="domain interfaces [active]"
                     /db_xref="CDD:238178"
     Site            order(94,96,134,265,291,293,317,349)
                     /site_type="active"
                     /db_xref="CDD:238178"
     CDS             1..552
                     /gene="PKM"
                     /gene_synonym="CTHBP; HEL-S-30; OIP3; p58; PK3; PKM2; TCB;
                     THBP1"
                     /coded_by="XM_047432664.1:2258..3916"
                     /db_xref="GeneID:5315"
                     /db_xref="HGNC:HGNC:9021"
                     /db_xref="MIM:179050"
ORIGIN      
        1 mtqpfnysaf eriifagtsa amskphseag tafiqtqqlh aamadtfleh mcrldidspp
       61 itarntgiic tigpasrsve tlkemiksgm nvarlnfshg theyhaetik nvrtatesfa
      121 sdpilyrpva valdtkgpei rtglikgsgt aevelkkgat lkitldnaym ekcdenilwl
      181 dyknickvve vgskiyvddg lislqvkqkg adflvteven ggslgskkgv nlpgaavdlp
      241 avsekdiqdl kfgveqdvdm vfasfirkas dvhevrkvlg ekgknikiis kienhegvrr
      301 fdeileasdg imvargdlgi eipaekvfla qkmmigrcnr agkpvicatq mlesmikkpr
      361 ptraegsdva navldgadci mlsgetakgd ypleavrmqh liareaeaai yhlqlfeelr
      421 rlapitsdpt eatavgavea sfkccsgaii vltksgrsah qvaryrprap iiavtrnpqt
      481 arqahlyrgi fpvlckdpvq eawaedvdlr vnfamnvgka rgffkkgdvv ivltgwrpgs
      541 gftntmrvvp vp
//
LOCUS       XP_047288621             552 aa            linear   PRI 05-AUG-2025
DEFINITION  pyruvate kinase PKM isoform X6 [Homo sapiens].
ACCESSION   XP_047288621
VERSION     XP_047288621.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432665.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..552
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..552
                     /product="pyruvate kinase PKM isoform X6"
                     /calculated_mol_wt=60236
     Region          63..551
                     /region_name="Pyruvate_Kinase"
                     /note="Pyruvate kinase (PK): Large allosteric enzyme that
                     regulates glycolysis through binding of the substrate,
                     phosphoenolpyruvate, and one or more allosteric effectors.
                     Like other allosteric enzymes, PK has a high substrate
                     affinity R state and a low...; cd00288"
                     /db_xref="CDD:238178"
     Site            order(65..66,128,130,138..141,230..231,237,240..244,259,
                     267,274,285,321,339..340,344,376,378,407,409..410,464,466,
                     468,479,482..483,485,487..489)
                     /site_type="active"
                     /note="domain interfaces [active]"
                     /db_xref="CDD:238178"
     Site            order(94,96,134,265,291,293,317,349)
                     /site_type="active"
                     /db_xref="CDD:238178"
     CDS             1..552
                     /gene="PKM"
                     /gene_synonym="CTHBP; HEL-S-30; OIP3; p58; PK3; PKM2; TCB;
                     THBP1"
                     /coded_by="XM_047432665.1:2258..3916"
                     /db_xref="GeneID:5315"
                     /db_xref="HGNC:HGNC:9021"
                     /db_xref="MIM:179050"
ORIGIN      
        1 mtqpfnysaf eriifagtsa amskphseag tafiqtqqlh aamadtfleh mcrldidspp
       61 itarntgiic tigpasrsve tlkemiksgm nvarlnfshg theyhaetik nvrtatesfa
      121 sdpilyrpva valdtkgpei rtglikgsgt aevelkkgat lkitldnaym ekcdenilwl
      181 dyknickvve vgskiyvddg lislqvkqkg adflvteven ggslgskkgv nlpgaavdlp
      241 avsekdiqdl kfgveqdvdm vfasfirkas dvhevrkvlg ekgknikiis kienhegvrr
      301 fdeileasdg imvargdlgi eipaekvfla qkmmigrcnr agkpvicatq mlesmikkpr
      361 ptraegsdva navldgadci mlsgetakgd ypleavrmqh liareaeaam fhrklfeelv
      421 rasshstdlm eamamgsvea sykclaaali vltesgrsah qvaryrprap iiavtrnpqt
      481 arqahlyrgi fpvlckdpvq eawaedvdlr vnfamnvgka rgffkkgdvv ivltgwrpgs
      541 gftntmrvvp vp
//
LOCUS       XP_047288622             531 aa            linear   PRI 05-AUG-2025
DEFINITION  pyruvate kinase PKM isoform X7 [Homo sapiens].
ACCESSION   XP_047288622
VERSION     XP_047288622.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432666.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..531
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..531
                     /product="pyruvate kinase PKM isoform X7"
                     /calculated_mol_wt=57806
     Region          42..530
                     /region_name="Pyruvate_Kinase"
                     /note="Pyruvate kinase (PK): Large allosteric enzyme that
                     regulates glycolysis through binding of the substrate,
                     phosphoenolpyruvate, and one or more allosteric effectors.
                     Like other allosteric enzymes, PK has a high substrate
                     affinity R state and a low...; cd00288"
                     /db_xref="CDD:238178"
     Site            order(44..45,107,109,117..120,209..210,216,219..223,238,
                     246,253,264,300,318..319,323,355,357,386,388..389,443,445,
                     447,458,461..462,464,466..468)
                     /site_type="active"
                     /note="domain interfaces [active]"
                     /db_xref="CDD:238178"
     Site            order(73,75,113,244,270,272,296,328)
                     /site_type="active"
                     /db_xref="CDD:238178"
     CDS             1..531
                     /gene="PKM"
                     /gene_synonym="CTHBP; HEL-S-30; OIP3; p58; PK3; PKM2; TCB;
                     THBP1"
                     /coded_by="XM_047432666.1:1468..3063"
                     /db_xref="GeneID:5315"
                     /db_xref="HGNC:HGNC:9021"
                     /db_xref="MIM:179050"
ORIGIN      
        1 mskphseagt afiqtqqlha amadtflehm crldidsppi tarntgiict igpasrsvet
       61 lkemiksgmn varlnfshgt heyhaetikn vrtatesfas dpilyrpvav aldtkgpeir
      121 tglikgsgta evelkkgatl kitldnayme kcdenilwld yknickvvev gskiyvddgl
      181 islqvkqkga dflvteveng gslgskkgvn lpgaavdlpa vsekdiqdlk fgveqdvdmv
      241 fasfirkasd vhevrkvlge kgknikiisk ienhegvrrf deileasdgi mvargdlgie
      301 ipaekvflaq kmmigrcnra gkpvicatqm lesmikkprp traegsdvan avldgadcim
      361 lsgetakgdy pleavrmqhl iareaeaaiy hlqlfeelrr lapitsdpte atavgaveas
      421 fkccsgaiiv ltksgrsahq varyrprapi iavtrnpqta rqahlyrgif pvlckdpvqe
      481 awaedvdlrv nfamnvgkar gffkkgdvvi vltgwrpgsg ftntmrvvpv p
//
LOCUS       XP_005254502             531 aa            linear   PRI 05-AUG-2025
DEFINITION  pyruvate kinase PKM isoform X7 [Homo sapiens].
ACCESSION   XP_005254502
VERSION     XP_005254502.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254445.6
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..531
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..531
                     /product="pyruvate kinase PKM isoform X7"
                     /calculated_mol_wt=57806
     Region          42..530
                     /region_name="Pyruvate_Kinase"
                     /note="Pyruvate kinase (PK): Large allosteric enzyme that
                     regulates glycolysis through binding of the substrate,
                     phosphoenolpyruvate, and one or more allosteric effectors.
                     Like other allosteric enzymes, PK has a high substrate
                     affinity R state and a low...; cd00288"
                     /db_xref="CDD:238178"
     Site            order(44..45,107,109,117..120,209..210,216,219..223,238,
                     246,253,264,300,318..319,323,355,357,386,388..389,443,445,
                     447,458,461..462,464,466..468)
                     /site_type="active"
                     /note="domain interfaces [active]"
                     /db_xref="CDD:238178"
     Site            order(73,75,113,244,270,272,296,328)
                     /site_type="active"
                     /db_xref="CDD:238178"
     CDS             1..531
                     /gene="PKM"
                     /gene_synonym="CTHBP; HEL-S-30; OIP3; p58; PK3; PKM2; TCB;
                     THBP1"
                     /coded_by="XM_005254445.6:156..1751"
                     /db_xref="GeneID:5315"
                     /db_xref="HGNC:HGNC:9021"
                     /db_xref="MIM:179050"
ORIGIN      
        1 mskphseagt afiqtqqlha amadtflehm crldidsppi tarntgiict igpasrsvet
       61 lkemiksgmn varlnfshgt heyhaetikn vrtatesfas dpilyrpvav aldtkgpeir
      121 tglikgsgta evelkkgatl kitldnayme kcdenilwld yknickvvev gskiyvddgl
      181 islqvkqkga dflvteveng gslgskkgvn lpgaavdlpa vsekdiqdlk fgveqdvdmv
      241 fasfirkasd vhevrkvlge kgknikiisk ienhegvrrf deileasdgi mvargdlgie
      301 ipaekvflaq kmmigrcnra gkpvicatqm lesmikkprp traegsdvan avldgadcim
      361 lsgetakgdy pleavrmqhl iareaeaaiy hlqlfeelrr lapitsdpte atavgaveas
      421 fkccsgaiiv ltksgrsahq varyrprapi iavtrnpqta rqahlyrgif pvlckdpvqe
      481 awaedvdlrv nfamnvgkar gffkkgdvvi vltgwrpgsg ftntmrvvpv p
//
LOCUS       XP_016877803            1205 aa            linear   PRI 05-AUG-2025
DEFINITION  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
            isoform X1 [Homo sapiens].
ACCESSION   XP_016877803
VERSION     XP_016877803.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022314.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1205
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1205
                     /product="1-phosphatidylinositol 4,5-bisphosphate
                     phosphodiesterase beta-2 isoform X1"
                     /calculated_mol_wt=136101
     Region          12..141
                     /region_name="PH_14"
                     /note="PH domain; pfam17787"
                     /db_xref="CDD:465506"
     Region          149..299
                     /region_name="EFh_PI-PLCbeta2"
                     /note="EF-hand motif found in phosphoinositide
                     phospholipase C beta 2 (PI-PLC-beta2); cd16209"
                     /db_xref="CDD:320039"
     Region          149..178
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          182..211
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          220..249
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          266..299
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          311..662
                     /region_name="PI-PLCc_beta2"
                     /note="Catalytic domain of metazoan
                     phosphoinositide-specific phospholipase C-beta2; cd08624"
                     /db_xref="CDD:176561"
     Site            order(327..328,357,359,374,408,461,463,588,615,617)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:176561"
     Site            order(327,374)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:176561"
     Site            order(328,357,359,408)
                     /site_type="other"
                     /note="Ca binding site [ion binding]"
                     /db_xref="CDD:176561"
     Region          694..815
                     /region_name="C2_PLC_like"
                     /note="C2 domain present in Phosphoinositide-specific
                     phospholipases C (PLC); cd00275"
                     /db_xref="CDD:175974"
     Site            order(713,738,770,774,776)
                     /site_type="other"
                     /note="Ca2+ binding pocket [ion binding]"
                     /db_xref="CDD:175974"
     Region          892..>1087
                     /region_name="YhaN"
                     /note="Uncharacterized conserved protein YhaN, contains
                     AAA domain [Function unknown]; COG4717"
                     /db_xref="CDD:443752"
     Region          991..1173
                     /region_name="PLC-beta_C"
                     /note="PLC-beta C terminal; pfam08703"
                     /db_xref="CDD:462571"
     CDS             1..1205
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /coded_by="XM_017022314.3:264..3881"
                     /db_xref="GeneID:5330"
                     /db_xref="HGNC:HGNC:9055"
                     /db_xref="MIM:604114"
ORIGIN      
        1 msllnpvllp pkvkaylsqg erfikwddet tvaspvilrv dpkgyylywt yqskemefld
       61 itsirdtrfg kfakmpksqk lrdvfnmdfp dnsfllktlt vvsgpdmvdl tfhnfvsyke
      121 nvgkawaedv lalvkhplta nasrstfldk ilvklkmqln segkipvknf fqmfpadrkr
      181 veaalsachl pkgkndainp edfpepvyks flmslcprpe ideiftsyha kakpymtkeh
      241 ltkfinqkqr dsrlnsllfp parpdqvqgl idkyepsgin aqrgqlspeg mvwflcgpen
      301 svlaqdklll hhdmtqplnh yfinsshnty ltagqfsgls saemyrqvll sgcrcveldc
      361 wkgkppdeep iithgftmtt diffkeaiea iaesafktsp ypiilsfenh vdsprqqakm
      421 aeycrtifgd mllteplekf plkpgvplps pedlrgkili knkknqfsgp tssskdtgge
      481 aegssppsap agegtvwage egteleeeev eeeeeeesgn ldeeeikkmq sdegtaglev
      541 tayeemsslv nyiqptkfvs fefsaprlft cifsghkhkk nrsyvissft elkaydllsk
      601 asvqfvdynk rqmsriypkg trmdssnymp qmfwnagcqm valnfqtmdl pmqqnmavfe
      661 fngqsgyllk hefmrrpdkq fnpfsvdrid vvvattlsit visgqflser svrtyvevel
      721 fglpgdpkrr yrtklspstn sinpvwkeep fvfekilmpe laslrvavme egnkflghri
      781 ipinalnsgy hhlclhsesn mpltmpalfi flemkdyipg awadltvala npikffsahd
      841 tksvklkeam gglpekpfpl aspvasqvng alaptsngsp aaragareea mkeaaeprta
      901 sleelrelkg vvklqrrhek elrelerrga rrweellqrg aaqlaelgpp gvggvgackl
      961 gpgkgsrkkr slpreesaga apgegpegvd grvrelkdrl elellrqgee qyecvlkrke
     1021 qhvaeqiskm melarekqaa elkalketse ndtkemkkkl etkrleriqg mtkvttdkma
     1081 qerlkreinn shiqevvqvi kqmtenlerh qekleekqaa cleqiremek qgsllspqfq
     1141 kealaeyear mkgleaevke svraclrtcf pseakdkper acecppelce qdpliakada
     1201 qesrl
//
LOCUS       XP_047288623            1204 aa            linear   PRI 05-AUG-2025
DEFINITION  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
            isoform X2 [Homo sapiens].
ACCESSION   XP_047288623
VERSION     XP_047288623.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432667.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1204
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1204
                     /product="1-phosphatidylinositol 4,5-bisphosphate
                     phosphodiesterase beta-2 isoform X2"
                     /calculated_mol_wt=136030
     Region          12..141
                     /region_name="PH_14"
                     /note="PH domain; pfam17787"
                     /db_xref="CDD:465506"
     Region          149..299
                     /region_name="EFh_PI-PLCbeta2"
                     /note="EF-hand motif found in phosphoinositide
                     phospholipase C beta 2 (PI-PLC-beta2); cd16209"
                     /db_xref="CDD:320039"
     Region          149..178
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          182..211
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          220..249
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          266..299
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          311..662
                     /region_name="PI-PLCc_beta2"
                     /note="Catalytic domain of metazoan
                     phosphoinositide-specific phospholipase C-beta2; cd08624"
                     /db_xref="CDD:176561"
     Site            order(327..328,357,359,374,408,461,463,588,615,617)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:176561"
     Site            order(327,374)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:176561"
     Site            order(328,357,359,408)
                     /site_type="other"
                     /note="Ca binding site [ion binding]"
                     /db_xref="CDD:176561"
     Region          694..815
                     /region_name="C2_PLC_like"
                     /note="C2 domain present in Phosphoinositide-specific
                     phospholipases C (PLC); cd00275"
                     /db_xref="CDD:175974"
     Site            order(713,738,770,774,776)
                     /site_type="other"
                     /note="Ca2+ binding pocket [ion binding]"
                     /db_xref="CDD:175974"
     Region          885..>1086
                     /region_name="YhaN"
                     /note="Uncharacterized conserved protein YhaN, contains
                     AAA domain [Function unknown]; COG4717"
                     /db_xref="CDD:443752"
     Region          990..1172
                     /region_name="PLC-beta_C"
                     /note="PLC-beta C terminal; pfam08703"
                     /db_xref="CDD:462571"
     CDS             1..1204
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /coded_by="XM_047432667.1:264..3878"
                     /db_xref="GeneID:5330"
                     /db_xref="HGNC:HGNC:9055"
                     /db_xref="MIM:604114"
ORIGIN      
        1 msllnpvllp pkvkaylsqg erfikwddet tvaspvilrv dpkgyylywt yqskemefld
       61 itsirdtrfg kfakmpksqk lrdvfnmdfp dnsfllktlt vvsgpdmvdl tfhnfvsyke
      121 nvgkawaedv lalvkhplta nasrstfldk ilvklkmqln segkipvknf fqmfpadrkr
      181 veaalsachl pkgkndainp edfpepvyks flmslcprpe ideiftsyha kakpymtkeh
      241 ltkfinqkqr dsrlnsllfp parpdqvqgl idkyepsgin aqrgqlspeg mvwflcgpen
      301 svlaqdklll hhdmtqplnh yfinsshnty ltagqfsgls saemyrqvll sgcrcveldc
      361 wkgkppdeep iithgftmtt diffkeaiea iaesafktsp ypiilsfenh vdsprqqakm
      421 aeycrtifgd mllteplekf plkpgvplps pedlrgkili knkknqfsgp tssskdtgge
      481 aegssppsap agegtvwage egteleeeev eeeeeeesgn ldeeeikkmq sdegtaglev
      541 tayeemsslv nyiqptkfvs fefsaprlft cifsghkhkk nrsyvissft elkaydllsk
      601 asvqfvdynk rqmsriypkg trmdssnymp qmfwnagcqm valnfqtmdl pmqqnmavfe
      661 fngqsgyllk hefmrrpdkq fnpfsvdrid vvvattlsit visgqflser svrtyvevel
      721 fglpgdpkrr yrtklspstn sinpvwkeep fvfekilmpe laslrvavme egnkflghri
      781 ipinalnsgy hhlclhsesn mpltmpalfi flemkdyipg awadltvala npikffsahd
      841 tksvklkeam gglpekpfpl aspvasqvng alaptsngsp aragareeam keaaeprtas
      901 leelrelkgv vklqrrheke lrelerrgar rweellqrga aqlaelgppg vggvgacklg
      961 pgkgsrkkrs lpreesagaa pgegpegvdg rvrelkdrle lellrqgeeq yecvlkrkeq
     1021 hvaeqiskmm elarekqaae lkalketsen dtkemkkkle tkrleriqgm tkvttdkmaq
     1081 erlkreinns hiqevvqvik qmtenlerhq ekleekqaac leqiremekq gsllspqfqk
     1141 ealaeyearm kgleaevkes vraclrtcfp seakdkpera cecppelceq dpliakadaq
     1201 esrl
//
LOCUS       XP_047288624            1201 aa            linear   PRI 05-AUG-2025
DEFINITION  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
            isoform X3 [Homo sapiens].
ACCESSION   XP_047288624
VERSION     XP_047288624.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432668.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1201
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1201
                     /product="1-phosphatidylinositol 4,5-bisphosphate
                     phosphodiesterase beta-2 isoform X3"
                     /calculated_mol_wt=135757
     Region          12..141
                     /region_name="PH_14"
                     /note="PH domain; pfam17787"
                     /db_xref="CDD:465506"
     Region          149..299
                     /region_name="EFh_PI-PLCbeta2"
                     /note="EF-hand motif found in phosphoinositide
                     phospholipase C beta 2 (PI-PLC-beta2); cd16209"
                     /db_xref="CDD:320039"
     Region          149..178
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          182..211
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          220..249
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          266..299
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          311..658
                     /region_name="PI-PLCc_beta2"
                     /note="Catalytic domain of metazoan
                     phosphoinositide-specific phospholipase C-beta2; cd08624"
                     /db_xref="CDD:176561"
     Site            order(327..328,357,359,374,408,461,463,584,611,613)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:176561"
     Site            order(327,374)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:176561"
     Site            order(328,357,359,408)
                     /site_type="other"
                     /note="Ca binding site [ion binding]"
                     /db_xref="CDD:176561"
     Region          690..811
                     /region_name="C2_PLC_like"
                     /note="C2 domain present in Phosphoinositide-specific
                     phospholipases C (PLC); cd00275"
                     /db_xref="CDD:175974"
     Site            order(709,734,766,770,772)
                     /site_type="other"
                     /note="Ca2+ binding pocket [ion binding]"
                     /db_xref="CDD:175974"
     Region          888..>1083
                     /region_name="YhaN"
                     /note="Uncharacterized conserved protein YhaN, contains
                     AAA domain [Function unknown]; COG4717"
                     /db_xref="CDD:443752"
     Region          987..1169
                     /region_name="PLC-beta_C"
                     /note="PLC-beta C terminal; pfam08703"
                     /db_xref="CDD:462571"
     CDS             1..1201
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /coded_by="XM_047432668.1:264..3869"
                     /db_xref="GeneID:5330"
                     /db_xref="HGNC:HGNC:9055"
                     /db_xref="MIM:604114"
ORIGIN      
        1 msllnpvllp pkvkaylsqg erfikwddet tvaspvilrv dpkgyylywt yqskemefld
       61 itsirdtrfg kfakmpksqk lrdvfnmdfp dnsfllktlt vvsgpdmvdl tfhnfvsyke
      121 nvgkawaedv lalvkhplta nasrstfldk ilvklkmqln segkipvknf fqmfpadrkr
      181 veaalsachl pkgkndainp edfpepvyks flmslcprpe ideiftsyha kakpymtkeh
      241 ltkfinqkqr dsrlnsllfp parpdqvqgl idkyepsgin aqrgqlspeg mvwflcgpen
      301 svlaqdklll hhdmtqplnh yfinsshnty ltagqfsgls saemyrqvll sgcrcveldc
      361 wkgkppdeep iithgftmtt diffkeaiea iaesafktsp ypiilsfenh vdsprqqakm
      421 aeycrtifgd mllteplekf plkpgvplps pedlrgkili knkknqfsgp tssskdtgge
      481 aegssppsap avwageegte leeeeveeee eeesgnldee eikkmqsdeg taglevtaye
      541 emsslvnyiq ptkfvsfefs aprlftcifs ghkhkknrsy vissftelka ydllskasvq
      601 fvdynkrqms riypkgtrmd ssnympqmfw nagcqmvaln fqtmdlpmqq nmavfefngq
      661 sgyllkhefm rrpdkqfnpf svdridvvva ttlsitvisg qflsersvrt yvevelfglp
      721 gdpkrryrtk lspstnsinp vwkeepfvfe kilmpelasl rvavmeegnk flghriipin
      781 alnsgyhhlc lhsesnmplt mpalfiflem kdyipgawad ltvalanpik ffsahdtksv
      841 klkeamgglp ekpfplaspv asqvngalap tsngspaara gareeamkea aeprtaslee
      901 lrelkgvvkl qrrhekelre lerrgarrwe ellqrgaaql aelgppgvgg vgacklgpgk
      961 gsrkkrslpr eesagaapge gpegvdgrvr elkdrlelel lrqgeeqyec vlkrkeqhva
     1021 eqiskmmela rekqaaelka lketsendtk emkkkletkr leriqgmtkv ttdkmaqerl
     1081 kreinnshiq evvqvikqmt enlerhqekl eekqaacleq iremekqgsl lspqfqkeal
     1141 aeyearmkgl eaevkesvra clrtcfpsea kdkperacec ppelceqdpl iakadaqesr
     1201 l
//
LOCUS       XP_016877806            1198 aa            linear   PRI 05-AUG-2025
DEFINITION  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
            isoform X4 [Homo sapiens].
ACCESSION   XP_016877806
VERSION     XP_016877806.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022317.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1198
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1198
                     /product="1-phosphatidylinositol 4,5-bisphosphate
                     phosphodiesterase beta-2 isoform X4"
                     /calculated_mol_wt=135419
     Region          12..141
                     /region_name="PH_14"
                     /note="PH domain; pfam17787"
                     /db_xref="CDD:465506"
     Region          149..299
                     /region_name="EFh_PI-PLCbeta2"
                     /note="EF-hand motif found in phosphoinositide
                     phospholipase C beta 2 (PI-PLC-beta2); cd16209"
                     /db_xref="CDD:320039"
     Region          149..178
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          182..211
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          220..249
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          266..299
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          311..662
                     /region_name="PI-PLCc_beta2"
                     /note="Catalytic domain of metazoan
                     phosphoinositide-specific phospholipase C-beta2; cd08624"
                     /db_xref="CDD:176561"
     Site            order(327..328,357,359,374,408,461,463,588,615,617)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:176561"
     Site            order(327,374)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:176561"
     Site            order(328,357,359,408)
                     /site_type="other"
                     /note="Ca binding site [ion binding]"
                     /db_xref="CDD:176561"
     Region          694..815
                     /region_name="C2_PLC_like"
                     /note="C2 domain present in Phosphoinositide-specific
                     phospholipases C (PLC); cd00275"
                     /db_xref="CDD:175974"
     Site            order(713,738,770,774,776)
                     /site_type="other"
                     /note="Ca2+ binding pocket [ion binding]"
                     /db_xref="CDD:175974"
     Region          892..>1087
                     /region_name="YhaN"
                     /note="Uncharacterized conserved protein YhaN, contains
                     AAA domain [Function unknown]; COG4717"
                     /db_xref="CDD:443752"
     Region          991..1166
                     /region_name="PLC-beta_C"
                     /note="PLC-beta C terminal; pfam08703"
                     /db_xref="CDD:462571"
     CDS             1..1198
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /coded_by="XM_017022317.3:264..3860"
                     /db_xref="GeneID:5330"
                     /db_xref="HGNC:HGNC:9055"
                     /db_xref="MIM:604114"
ORIGIN      
        1 msllnpvllp pkvkaylsqg erfikwddet tvaspvilrv dpkgyylywt yqskemefld
       61 itsirdtrfg kfakmpksqk lrdvfnmdfp dnsfllktlt vvsgpdmvdl tfhnfvsyke
      121 nvgkawaedv lalvkhplta nasrstfldk ilvklkmqln segkipvknf fqmfpadrkr
      181 veaalsachl pkgkndainp edfpepvyks flmslcprpe ideiftsyha kakpymtkeh
      241 ltkfinqkqr dsrlnsllfp parpdqvqgl idkyepsgin aqrgqlspeg mvwflcgpen
      301 svlaqdklll hhdmtqplnh yfinsshnty ltagqfsgls saemyrqvll sgcrcveldc
      361 wkgkppdeep iithgftmtt diffkeaiea iaesafktsp ypiilsfenh vdsprqqakm
      421 aeycrtifgd mllteplekf plkpgvplps pedlrgkili knkknqfsgp tssskdtgge
      481 aegssppsap agegtvwage egteleeeev eeeeeeesgn ldeeeikkmq sdegtaglev
      541 tayeemsslv nyiqptkfvs fefsaprlft cifsghkhkk nrsyvissft elkaydllsk
      601 asvqfvdynk rqmsriypkg trmdssnymp qmfwnagcqm valnfqtmdl pmqqnmavfe
      661 fngqsgyllk hefmrrpdkq fnpfsvdrid vvvattlsit visgqflser svrtyvevel
      721 fglpgdpkrr yrtklspstn sinpvwkeep fvfekilmpe laslrvavme egnkflghri
      781 ipinalnsgy hhlclhsesn mpltmpalfi flemkdyipg awadltvala npikffsahd
      841 tksvklkeam gglpekpfpl aspvasqvng alaptsngsp aaragareea mkeaaeprta
      901 sleelrelkg vvklqrrhek elrelerrga rrweellqrg aaqlaelgpp gvggvgackl
      961 gpgkgsrkkr slpreesaga apgegpegvd grvrelkdrl elellrqgee qyecvlkrke
     1021 qhvaeqiskm melarekqaa elkalketse ndtkemkkkl etkrleriqg mtkvttdkma
     1081 qerlkreinn shiqevvqvi kqmtenlerh qekleekqaa cleqiremek qfqkealaey
     1141 earmkgleae vkesvraclr tcfpseakdk peracecppe lceqdpliak adaqesrl
//
LOCUS       XP_047288625            1192 aa            linear   PRI 05-AUG-2025
DEFINITION  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
            isoform X5 [Homo sapiens].
ACCESSION   XP_047288625
VERSION     XP_047288625.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432669.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1192
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1192
                     /product="1-phosphatidylinositol 4,5-bisphosphate
                     phosphodiesterase beta-2 isoform X5"
                     /calculated_mol_wt=134577
     Region          12..141
                     /region_name="PH_14"
                     /note="PH domain; pfam17787"
                     /db_xref="CDD:465506"
     Region          149..299
                     /region_name="EFh_PI-PLCbeta2"
                     /note="EF-hand motif found in phosphoinositide
                     phospholipase C beta 2 (PI-PLC-beta2); cd16209"
                     /db_xref="CDD:320039"
     Region          149..178
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          182..211
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          220..249
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          266..299
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          311..649
                     /region_name="PI-PLCc_beta2"
                     /note="Catalytic domain of metazoan
                     phosphoinositide-specific phospholipase C-beta2; cd08624"
                     /db_xref="CDD:176561"
     Site            order(327..328,357,359,374,408,461,463,575,602,604)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:176561"
     Site            order(327,374)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:176561"
     Site            order(328,357,359,408)
                     /site_type="other"
                     /note="Ca binding site [ion binding]"
                     /db_xref="CDD:176561"
     Region          681..802
                     /region_name="C2_PLC_like"
                     /note="C2 domain present in Phosphoinositide-specific
                     phospholipases C (PLC); cd00275"
                     /db_xref="CDD:175974"
     Site            order(700,725,757,761,763)
                     /site_type="other"
                     /note="Ca2+ binding pocket [ion binding]"
                     /db_xref="CDD:175974"
     Region          879..>1074
                     /region_name="YhaN"
                     /note="Uncharacterized conserved protein YhaN, contains
                     AAA domain [Function unknown]; COG4717"
                     /db_xref="CDD:443752"
     Region          978..1160
                     /region_name="PLC-beta_C"
                     /note="PLC-beta C terminal; pfam08703"
                     /db_xref="CDD:462571"
     CDS             1..1192
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /coded_by="XM_047432669.1:264..3842"
                     /db_xref="GeneID:5330"
                     /db_xref="HGNC:HGNC:9055"
                     /db_xref="MIM:604114"
ORIGIN      
        1 msllnpvllp pkvkaylsqg erfikwddet tvaspvilrv dpkgyylywt yqskemefld
       61 itsirdtrfg kfakmpksqk lrdvfnmdfp dnsfllktlt vvsgpdmvdl tfhnfvsyke
      121 nvgkawaedv lalvkhplta nasrstfldk ilvklkmqln segkipvknf fqmfpadrkr
      181 veaalsachl pkgkndainp edfpepvyks flmslcprpe ideiftsyha kakpymtkeh
      241 ltkfinqkqr dsrlnsllfp parpdqvqgl idkyepsgin aqrgqlspeg mvwflcgpen
      301 svlaqdklll hhdmtqplnh yfinsshnty ltagqfsgls saemyrqvll sgcrcveldc
      361 wkgkppdeep iithgftmtt diffkeaiea iaesafktsp ypiilsfenh vdsprqqakm
      421 aeycrtifgd mllteplekf plkpgvplps pedlrgkili knkknqfsgp tssskdtgge
      481 aegssppsap agegtvwage egteleeeev eeeeeeesgn ldeeeikkmq sdegtaglev
      541 tayeemsslv nyiqptkfvs fefsaqknrs yvissftelk aydllskasv qfvdynkrqm
      601 sriypkgtrm dssnympqmf wnagcqmval nfqtmdlpmq qnmavfefng qsgyllkhef
      661 mrrpdkqfnp fsvdridvvv attlsitvis gqflsersvr tyvevelfgl pgdpkrryrt
      721 klspstnsin pvwkeepfvf ekilmpelas lrvavmeegn kflghriipi nalnsgyhhl
      781 clhsesnmpl tmpalfifle mkdyipgawa dltvalanpi kffsahdtks vklkeamggl
      841 pekpfplasp vasqvngala ptsngspaar agareeamke aaeprtasle elrelkgvvk
      901 lqrrhekelr elerrgarrw eellqrgaaq laelgppgvg gvgacklgpg kgsrkkrslp
      961 reesagaapg egpegvdgrv relkdrlele llrqgeeqye cvlkrkeqhv aeqiskmmel
     1021 arekqaaelk alketsendt kemkkkletk rleriqgmtk vttdkmaqer lkreinnshi
     1081 qevvqvikqm tenlerhqek leekqaacle qiremekqgs llspqfqkea laeyearmkg
     1141 leaevkesvr aclrtcfpse akdkperace cppelceqdp liakadaqes rl
//
LOCUS       XP_047288626            1191 aa            linear   PRI 05-AUG-2025
DEFINITION  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
            isoform X6 [Homo sapiens].
ACCESSION   XP_047288626
VERSION     XP_047288626.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432670.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1191
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1191
                     /product="1-phosphatidylinositol 4,5-bisphosphate
                     phosphodiesterase beta-2 isoform X6"
                     /calculated_mol_wt=134506
     Region          12..141
                     /region_name="PH_14"
                     /note="PH domain; pfam17787"
                     /db_xref="CDD:465506"
     Region          149..299
                     /region_name="EFh_PI-PLCbeta2"
                     /note="EF-hand motif found in phosphoinositide
                     phospholipase C beta 2 (PI-PLC-beta2); cd16209"
                     /db_xref="CDD:320039"
     Region          149..178
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          182..211
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          220..249
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          266..299
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          311..649
                     /region_name="PI-PLCc_beta2"
                     /note="Catalytic domain of metazoan
                     phosphoinositide-specific phospholipase C-beta2; cd08624"
                     /db_xref="CDD:176561"
     Site            order(327..328,357,359,374,408,461,463,575,602,604)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:176561"
     Site            order(327,374)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:176561"
     Site            order(328,357,359,408)
                     /site_type="other"
                     /note="Ca binding site [ion binding]"
                     /db_xref="CDD:176561"
     Region          681..802
                     /region_name="C2_PLC_like"
                     /note="C2 domain present in Phosphoinositide-specific
                     phospholipases C (PLC); cd00275"
                     /db_xref="CDD:175974"
     Site            order(700,725,757,761,763)
                     /site_type="other"
                     /note="Ca2+ binding pocket [ion binding]"
                     /db_xref="CDD:175974"
     Region          872..>1073
                     /region_name="YhaN"
                     /note="Uncharacterized conserved protein YhaN, contains
                     AAA domain [Function unknown]; COG4717"
                     /db_xref="CDD:443752"
     Region          977..1159
                     /region_name="PLC-beta_C"
                     /note="PLC-beta C terminal; pfam08703"
                     /db_xref="CDD:462571"
     CDS             1..1191
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /coded_by="XM_047432670.1:264..3839"
                     /db_xref="GeneID:5330"
                     /db_xref="HGNC:HGNC:9055"
                     /db_xref="MIM:604114"
ORIGIN      
        1 msllnpvllp pkvkaylsqg erfikwddet tvaspvilrv dpkgyylywt yqskemefld
       61 itsirdtrfg kfakmpksqk lrdvfnmdfp dnsfllktlt vvsgpdmvdl tfhnfvsyke
      121 nvgkawaedv lalvkhplta nasrstfldk ilvklkmqln segkipvknf fqmfpadrkr
      181 veaalsachl pkgkndainp edfpepvyks flmslcprpe ideiftsyha kakpymtkeh
      241 ltkfinqkqr dsrlnsllfp parpdqvqgl idkyepsgin aqrgqlspeg mvwflcgpen
      301 svlaqdklll hhdmtqplnh yfinsshnty ltagqfsgls saemyrqvll sgcrcveldc
      361 wkgkppdeep iithgftmtt diffkeaiea iaesafktsp ypiilsfenh vdsprqqakm
      421 aeycrtifgd mllteplekf plkpgvplps pedlrgkili knkknqfsgp tssskdtgge
      481 aegssppsap agegtvwage egteleeeev eeeeeeesgn ldeeeikkmq sdegtaglev
      541 tayeemsslv nyiqptkfvs fefsaqknrs yvissftelk aydllskasv qfvdynkrqm
      601 sriypkgtrm dssnympqmf wnagcqmval nfqtmdlpmq qnmavfefng qsgyllkhef
      661 mrrpdkqfnp fsvdridvvv attlsitvis gqflsersvr tyvevelfgl pgdpkrryrt
      721 klspstnsin pvwkeepfvf ekilmpelas lrvavmeegn kflghriipi nalnsgyhhl
      781 clhsesnmpl tmpalfifle mkdyipgawa dltvalanpi kffsahdtks vklkeamggl
      841 pekpfplasp vasqvngala ptsngspara gareeamkea aeprtaslee lrelkgvvkl
      901 qrrhekelre lerrgarrwe ellqrgaaql aelgppgvgg vgacklgpgk gsrkkrslpr
      961 eesagaapge gpegvdgrvr elkdrlelel lrqgeeqyec vlkrkeqhva eqiskmmela
     1021 rekqaaelka lketsendtk emkkkletkr leriqgmtkv ttdkmaqerl kreinnshiq
     1081 evvqvikqmt enlerhqekl eekqaacleq iremekqgsl lspqfqkeal aeyearmkgl
     1141 eaevkesvra clrtcfpsea kdkperacec ppelceqdpl iakadaqesr l
//
LOCUS       XP_047288627            1190 aa            linear   PRI 05-AUG-2025
DEFINITION  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
            isoform X7 [Homo sapiens].
ACCESSION   XP_047288627
VERSION     XP_047288627.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432671.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1190
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1190
                     /product="1-phosphatidylinositol 4,5-bisphosphate
                     phosphodiesterase beta-2 isoform X7"
                     /calculated_mol_wt=134588
     Region          12..141
                     /region_name="PH_14"
                     /note="PH domain; pfam17787"
                     /db_xref="CDD:465506"
     Region          149..299
                     /region_name="EFh_PI-PLCbeta2"
                     /note="EF-hand motif found in phosphoinositide
                     phospholipase C beta 2 (PI-PLC-beta2); cd16209"
                     /db_xref="CDD:320039"
     Region          149..178
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          182..211
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          220..249
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          266..299
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          311..662
                     /region_name="PI-PLCc_beta2"
                     /note="Catalytic domain of metazoan
                     phosphoinositide-specific phospholipase C-beta2; cd08624"
                     /db_xref="CDD:176561"
     Site            order(327..328,357,359,374,408,461,463,588,615,617)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:176561"
     Site            order(327,374)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:176561"
     Site            order(328,357,359,408)
                     /site_type="other"
                     /note="Ca binding site [ion binding]"
                     /db_xref="CDD:176561"
     Region          694..815
                     /region_name="C2_PLC_like"
                     /note="C2 domain present in Phosphoinositide-specific
                     phospholipases C (PLC); cd00275"
                     /db_xref="CDD:175974"
     Site            order(713,738,770,774,776)
                     /site_type="other"
                     /note="Ca2+ binding pocket [ion binding]"
                     /db_xref="CDD:175974"
     Region          976..1158
                     /region_name="PLC-beta_C"
                     /note="PLC-beta C terminal; pfam08703"
                     /db_xref="CDD:462571"
     CDS             1..1190
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /coded_by="XM_047432671.1:264..3836"
                     /db_xref="GeneID:5330"
                     /db_xref="HGNC:HGNC:9055"
                     /db_xref="MIM:604114"
ORIGIN      
        1 msllnpvllp pkvkaylsqg erfikwddet tvaspvilrv dpkgyylywt yqskemefld
       61 itsirdtrfg kfakmpksqk lrdvfnmdfp dnsfllktlt vvsgpdmvdl tfhnfvsyke
      121 nvgkawaedv lalvkhplta nasrstfldk ilvklkmqln segkipvknf fqmfpadrkr
      181 veaalsachl pkgkndainp edfpepvyks flmslcprpe ideiftsyha kakpymtkeh
      241 ltkfinqkqr dsrlnsllfp parpdqvqgl idkyepsgin aqrgqlspeg mvwflcgpen
      301 svlaqdklll hhdmtqplnh yfinsshnty ltagqfsgls saemyrqvll sgcrcveldc
      361 wkgkppdeep iithgftmtt diffkeaiea iaesafktsp ypiilsfenh vdsprqqakm
      421 aeycrtifgd mllteplekf plkpgvplps pedlrgkili knkknqfsgp tssskdtgge
      481 aegssppsap agegtvwage egteleeeev eeeeeeesgn ldeeeikkmq sdegtaglev
      541 tayeemsslv nyiqptkfvs fefsaprlft cifsghkhkk nrsyvissft elkaydllsk
      601 asvqfvdynk rqmsriypkg trmdssnymp qmfwnagcqm valnfqtmdl pmqqnmavfe
      661 fngqsgyllk hefmrrpdkq fnpfsvdrid vvvattlsit visgqflser svrtyvevel
      721 fglpgdpkrr yrtklspstn sinpvwkeep fvfekilmpe laslrvavme egnkflghri
      781 ipinalnsgy hhlclhsesn mpltmpalfi flemkdyipg awadltvala npikffsahd
      841 tksvklkeam gglpekpfpl aspvasqvng alaptsngsp eprtasleel relkgvvklq
      901 rrhekelrel errgarrwee llqrgaaqla elgppgvggv gacklgpgkg srkkrslpre
      961 esagaapgeg pegvdgrvre lkdrlelell rqgeeqyecv lkrkeqhvae qiskmmelar
     1021 ekqaaelkal ketsendtke mkkkletkrl eriqgmtkvt tdkmaqerlk reinnshiqe
     1081 vvqvikqmte nlerhqekle ekqaacleqi remekqgsll spqfqkeala eyearmkgle
     1141 aevkesvrac lrtcfpseak dkperacecp pelceqdpli akadaqesrl
//
LOCUS       XP_047288628            1187 aa            linear   PRI 05-AUG-2025
DEFINITION  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
            isoform X8 [Homo sapiens].
ACCESSION   XP_047288628
VERSION     XP_047288628.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432672.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1187
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1187
                     /product="1-phosphatidylinositol 4,5-bisphosphate
                     phosphodiesterase beta-2 isoform X8"
                     /calculated_mol_wt=134161
     Region          12..141
                     /region_name="PH_14"
                     /note="PH domain; pfam17787"
                     /db_xref="CDD:465506"
     Region          149..299
                     /region_name="EFh_PI-PLCbeta2"
                     /note="EF-hand motif found in phosphoinositide
                     phospholipase C beta 2 (PI-PLC-beta2); cd16209"
                     /db_xref="CDD:320039"
     Region          149..178
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          182..211
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          220..249
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          266..299
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          311..645
                     /region_name="PI-PLCc_beta2"
                     /note="Catalytic domain of metazoan
                     phosphoinositide-specific phospholipase C-beta2; cd08624"
                     /db_xref="CDD:176561"
     Site            order(327..328,357,359,374,408,461,463,571,598,600)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:176561"
     Site            order(327,374)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:176561"
     Site            order(328,357,359,408)
                     /site_type="other"
                     /note="Ca binding site [ion binding]"
                     /db_xref="CDD:176561"
     Region          677..798
                     /region_name="C2_PLC_like"
                     /note="C2 domain present in Phosphoinositide-specific
                     phospholipases C (PLC); cd00275"
                     /db_xref="CDD:175974"
     Site            order(696,721,753,757,759)
                     /site_type="other"
                     /note="Ca2+ binding pocket [ion binding]"
                     /db_xref="CDD:175974"
     Region          868..>1069
                     /region_name="YhaN"
                     /note="Uncharacterized conserved protein YhaN, contains
                     AAA domain [Function unknown]; COG4717"
                     /db_xref="CDD:443752"
     Region          973..1155
                     /region_name="PLC-beta_C"
                     /note="PLC-beta C terminal; pfam08703"
                     /db_xref="CDD:462571"
     CDS             1..1187
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /coded_by="XM_047432672.1:264..3827"
                     /db_xref="GeneID:5330"
                     /db_xref="HGNC:HGNC:9055"
                     /db_xref="MIM:604114"
ORIGIN      
        1 msllnpvllp pkvkaylsqg erfikwddet tvaspvilrv dpkgyylywt yqskemefld
       61 itsirdtrfg kfakmpksqk lrdvfnmdfp dnsfllktlt vvsgpdmvdl tfhnfvsyke
      121 nvgkawaedv lalvkhplta nasrstfldk ilvklkmqln segkipvknf fqmfpadrkr
      181 veaalsachl pkgkndainp edfpepvyks flmslcprpe ideiftsyha kakpymtkeh
      241 ltkfinqkqr dsrlnsllfp parpdqvqgl idkyepsgin aqrgqlspeg mvwflcgpen
      301 svlaqdklll hhdmtqplnh yfinsshnty ltagqfsgls saemyrqvll sgcrcveldc
      361 wkgkppdeep iithgftmtt diffkeaiea iaesafktsp ypiilsfenh vdsprqqakm
      421 aeycrtifgd mllteplekf plkpgvplps pedlrgkili knkknqfsgp tssskdtgge
      481 aegssppsap avwageegte leeeeveeee eeesgnldee eikkmqsdeg taglevtaye
      541 emsslvnyiq ptkfvsfefs aqknrsyvis sftelkaydl lskasvqfvd ynkrqmsriy
      601 pkgtrmdssn ympqmfwnag cqmvalnfqt mdlpmqqnma vfefngqsgy llkhefmrrp
      661 dkqfnpfsvd ridvvvattl sitvisgqfl sersvrtyve velfglpgdp krryrtklsp
      721 stnsinpvwk eepfvfekil mpelaslrva vmeegnkflg hriipinaln sgyhhlclhs
      781 esnmpltmpa lfiflemkdy ipgawadltv alanpikffs ahdtksvklk eamgglpekp
      841 fplaspvasq vngalaptsn gsparagare eamkeaaepr tasleelrel kgvvklqrrh
      901 ekelrelerr garrweellq rgaaqlaelg ppgvggvgac klgpgkgsrk krslpreesa
      961 gaapgegpeg vdgrvrelkd rlelellrqg eeqyecvlkr keqhvaeqis kmmelarekq
     1021 aaelkalket sendtkemkk kletkrleri qgmtkvttdk maqerlkrei nnshiqevvq
     1081 vikqmtenle rhqekleekq aacleqirem ekqgsllspq fqkealaeye armkgleaev
     1141 kesvraclrt cfpseakdkp eracecppel ceqdpliaka daqesrl
//
LOCUS       XP_047288629            1184 aa            linear   PRI 05-AUG-2025
DEFINITION  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
            isoform X9 [Homo sapiens].
ACCESSION   XP_047288629
VERSION     XP_047288629.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432673.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1184
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1184
                     /product="1-phosphatidylinositol 4,5-bisphosphate
                     phosphodiesterase beta-2 isoform X9"
                     /calculated_mol_wt=133823
     Region          12..141
                     /region_name="PH_14"
                     /note="PH domain; pfam17787"
                     /db_xref="CDD:465506"
     Region          149..299
                     /region_name="EFh_PI-PLCbeta2"
                     /note="EF-hand motif found in phosphoinositide
                     phospholipase C beta 2 (PI-PLC-beta2); cd16209"
                     /db_xref="CDD:320039"
     Region          149..178
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          182..211
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          220..249
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          266..299
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          311..649
                     /region_name="PI-PLCc_beta2"
                     /note="Catalytic domain of metazoan
                     phosphoinositide-specific phospholipase C-beta2; cd08624"
                     /db_xref="CDD:176561"
     Site            order(327..328,357,359,374,408,461,463,575,602,604)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:176561"
     Site            order(327,374)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:176561"
     Site            order(328,357,359,408)
                     /site_type="other"
                     /note="Ca binding site [ion binding]"
                     /db_xref="CDD:176561"
     Region          681..802
                     /region_name="C2_PLC_like"
                     /note="C2 domain present in Phosphoinositide-specific
                     phospholipases C (PLC); cd00275"
                     /db_xref="CDD:175974"
     Site            order(700,725,757,761,763)
                     /site_type="other"
                     /note="Ca2+ binding pocket [ion binding]"
                     /db_xref="CDD:175974"
     Region          872..>1073
                     /region_name="YhaN"
                     /note="Uncharacterized conserved protein YhaN, contains
                     AAA domain [Function unknown]; COG4717"
                     /db_xref="CDD:443752"
     Region          977..1152
                     /region_name="PLC-beta_C"
                     /note="PLC-beta C terminal; pfam08703"
                     /db_xref="CDD:462571"
     CDS             1..1184
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /coded_by="XM_047432673.1:264..3818"
                     /db_xref="GeneID:5330"
                     /db_xref="HGNC:HGNC:9055"
                     /db_xref="MIM:604114"
ORIGIN      
        1 msllnpvllp pkvkaylsqg erfikwddet tvaspvilrv dpkgyylywt yqskemefld
       61 itsirdtrfg kfakmpksqk lrdvfnmdfp dnsfllktlt vvsgpdmvdl tfhnfvsyke
      121 nvgkawaedv lalvkhplta nasrstfldk ilvklkmqln segkipvknf fqmfpadrkr
      181 veaalsachl pkgkndainp edfpepvyks flmslcprpe ideiftsyha kakpymtkeh
      241 ltkfinqkqr dsrlnsllfp parpdqvqgl idkyepsgin aqrgqlspeg mvwflcgpen
      301 svlaqdklll hhdmtqplnh yfinsshnty ltagqfsgls saemyrqvll sgcrcveldc
      361 wkgkppdeep iithgftmtt diffkeaiea iaesafktsp ypiilsfenh vdsprqqakm
      421 aeycrtifgd mllteplekf plkpgvplps pedlrgkili knkknqfsgp tssskdtgge
      481 aegssppsap agegtvwage egteleeeev eeeeeeesgn ldeeeikkmq sdegtaglev
      541 tayeemsslv nyiqptkfvs fefsaqknrs yvissftelk aydllskasv qfvdynkrqm
      601 sriypkgtrm dssnympqmf wnagcqmval nfqtmdlpmq qnmavfefng qsgyllkhef
      661 mrrpdkqfnp fsvdridvvv attlsitvis gqflsersvr tyvevelfgl pgdpkrryrt
      721 klspstnsin pvwkeepfvf ekilmpelas lrvavmeegn kflghriipi nalnsgyhhl
      781 clhsesnmpl tmpalfifle mkdyipgawa dltvalanpi kffsahdtks vklkeamggl
      841 pekpfplasp vasqvngala ptsngspara gareeamkea aeprtaslee lrelkgvvkl
      901 qrrhekelre lerrgarrwe ellqrgaaql aelgppgvgg vgacklgpgk gsrkkrslpr
      961 eesagaapge gpegvdgrvr elkdrlelel lrqgeeqyec vlkrkeqhva eqiskmmela
     1021 rekqaaelka lketsendtk emkkkletkr leriqgmtkv ttdkmaqerl kreinnshiq
     1081 evvqvikqmt enlerhqekl eekqaacleq iremekqfqk ealaeyearm kgleaevkes
     1141 vraclrtcfp seakdkpera cecppelceq dpliakadaq esrl
//
LOCUS       XP_047288630            1183 aa            linear   PRI 05-AUG-2025
DEFINITION  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
            isoform X10 [Homo sapiens].
ACCESSION   XP_047288630
VERSION     XP_047288630.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432674.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1183
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1183
                     /product="1-phosphatidylinositol 4,5-bisphosphate
                     phosphodiesterase beta-2 isoform X10"
                     /calculated_mol_wt=133905
     Region          12..141
                     /region_name="PH_14"
                     /note="PH domain; pfam17787"
                     /db_xref="CDD:465506"
     Region          149..299
                     /region_name="EFh_PI-PLCbeta2"
                     /note="EF-hand motif found in phosphoinositide
                     phospholipase C beta 2 (PI-PLC-beta2); cd16209"
                     /db_xref="CDD:320039"
     Region          149..178
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          182..211
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          220..249
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          266..299
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          311..662
                     /region_name="PI-PLCc_beta2"
                     /note="Catalytic domain of metazoan
                     phosphoinositide-specific phospholipase C-beta2; cd08624"
                     /db_xref="CDD:176561"
     Site            order(327..328,357,359,374,408,461,463,588,615,617)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:176561"
     Site            order(327,374)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:176561"
     Site            order(328,357,359,408)
                     /site_type="other"
                     /note="Ca binding site [ion binding]"
                     /db_xref="CDD:176561"
     Region          694..815
                     /region_name="C2_PLC_like"
                     /note="C2 domain present in Phosphoinositide-specific
                     phospholipases C (PLC); cd00275"
                     /db_xref="CDD:175974"
     Site            order(713,738,770,774,776)
                     /site_type="other"
                     /note="Ca2+ binding pocket [ion binding]"
                     /db_xref="CDD:175974"
     Region          976..1151
                     /region_name="PLC-beta_C"
                     /note="PLC-beta C terminal; pfam08703"
                     /db_xref="CDD:462571"
     CDS             1..1183
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /coded_by="XM_047432674.1:264..3815"
                     /db_xref="GeneID:5330"
                     /db_xref="HGNC:HGNC:9055"
                     /db_xref="MIM:604114"
ORIGIN      
        1 msllnpvllp pkvkaylsqg erfikwddet tvaspvilrv dpkgyylywt yqskemefld
       61 itsirdtrfg kfakmpksqk lrdvfnmdfp dnsfllktlt vvsgpdmvdl tfhnfvsyke
      121 nvgkawaedv lalvkhplta nasrstfldk ilvklkmqln segkipvknf fqmfpadrkr
      181 veaalsachl pkgkndainp edfpepvyks flmslcprpe ideiftsyha kakpymtkeh
      241 ltkfinqkqr dsrlnsllfp parpdqvqgl idkyepsgin aqrgqlspeg mvwflcgpen
      301 svlaqdklll hhdmtqplnh yfinsshnty ltagqfsgls saemyrqvll sgcrcveldc
      361 wkgkppdeep iithgftmtt diffkeaiea iaesafktsp ypiilsfenh vdsprqqakm
      421 aeycrtifgd mllteplekf plkpgvplps pedlrgkili knkknqfsgp tssskdtgge
      481 aegssppsap agegtvwage egteleeeev eeeeeeesgn ldeeeikkmq sdegtaglev
      541 tayeemsslv nyiqptkfvs fefsaprlft cifsghkhkk nrsyvissft elkaydllsk
      601 asvqfvdynk rqmsriypkg trmdssnymp qmfwnagcqm valnfqtmdl pmqqnmavfe
      661 fngqsgyllk hefmrrpdkq fnpfsvdrid vvvattlsit visgqflser svrtyvevel
      721 fglpgdpkrr yrtklspstn sinpvwkeep fvfekilmpe laslrvavme egnkflghri
      781 ipinalnsgy hhlclhsesn mpltmpalfi flemkdyipg awadltvala npikffsahd
      841 tksvklkeam gglpekpfpl aspvasqvng alaptsngsp eprtasleel relkgvvklq
      901 rrhekelrel errgarrwee llqrgaaqla elgppgvggv gacklgpgkg srkkrslpre
      961 esagaapgeg pegvdgrvre lkdrlelell rqgeeqyecv lkrkeqhvae qiskmmelar
     1021 ekqaaelkal ketsendtke mkkkletkrl eriqgmtkvt tdkmaqerlk reinnshiqe
     1081 vvqvikqmte nlerhqekle ekqaacleqi remekqfqke alaeyearmk gleaevkesv
     1141 raclrtcfps eakdkperac ecppelceqd pliakadaqe srl
//
LOCUS       XP_047288631            1180 aa            linear   PRI 05-AUG-2025
DEFINITION  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
            isoform X11 [Homo sapiens].
ACCESSION   XP_047288631
VERSION     XP_047288631.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432675.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1180
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1180
                     /product="1-phosphatidylinositol 4,5-bisphosphate
                     phosphodiesterase beta-2 isoform X11"
                     /calculated_mol_wt=133478
     Region          12..141
                     /region_name="PH_14"
                     /note="PH domain; pfam17787"
                     /db_xref="CDD:465506"
     Region          149..299
                     /region_name="EFh_PI-PLCbeta2"
                     /note="EF-hand motif found in phosphoinositide
                     phospholipase C beta 2 (PI-PLC-beta2); cd16209"
                     /db_xref="CDD:320039"
     Region          149..178
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          182..211
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          220..249
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          266..299
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          311..645
                     /region_name="PI-PLCc_beta2"
                     /note="Catalytic domain of metazoan
                     phosphoinositide-specific phospholipase C-beta2; cd08624"
                     /db_xref="CDD:176561"
     Site            order(327..328,357,359,374,408,461,463,571,598,600)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:176561"
     Site            order(327,374)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:176561"
     Site            order(328,357,359,408)
                     /site_type="other"
                     /note="Ca binding site [ion binding]"
                     /db_xref="CDD:176561"
     Region          677..798
                     /region_name="C2_PLC_like"
                     /note="C2 domain present in Phosphoinositide-specific
                     phospholipases C (PLC); cd00275"
                     /db_xref="CDD:175974"
     Site            order(696,721,753,757,759)
                     /site_type="other"
                     /note="Ca2+ binding pocket [ion binding]"
                     /db_xref="CDD:175974"
     Region          868..>1069
                     /region_name="YhaN"
                     /note="Uncharacterized conserved protein YhaN, contains
                     AAA domain [Function unknown]; COG4717"
                     /db_xref="CDD:443752"
     Region          973..1148
                     /region_name="PLC-beta_C"
                     /note="PLC-beta C terminal; pfam08703"
                     /db_xref="CDD:462571"
     CDS             1..1180
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /coded_by="XM_047432675.1:264..3806"
                     /db_xref="GeneID:5330"
                     /db_xref="HGNC:HGNC:9055"
                     /db_xref="MIM:604114"
ORIGIN      
        1 msllnpvllp pkvkaylsqg erfikwddet tvaspvilrv dpkgyylywt yqskemefld
       61 itsirdtrfg kfakmpksqk lrdvfnmdfp dnsfllktlt vvsgpdmvdl tfhnfvsyke
      121 nvgkawaedv lalvkhplta nasrstfldk ilvklkmqln segkipvknf fqmfpadrkr
      181 veaalsachl pkgkndainp edfpepvyks flmslcprpe ideiftsyha kakpymtkeh
      241 ltkfinqkqr dsrlnsllfp parpdqvqgl idkyepsgin aqrgqlspeg mvwflcgpen
      301 svlaqdklll hhdmtqplnh yfinsshnty ltagqfsgls saemyrqvll sgcrcveldc
      361 wkgkppdeep iithgftmtt diffkeaiea iaesafktsp ypiilsfenh vdsprqqakm
      421 aeycrtifgd mllteplekf plkpgvplps pedlrgkili knkknqfsgp tssskdtgge
      481 aegssppsap avwageegte leeeeveeee eeesgnldee eikkmqsdeg taglevtaye
      541 emsslvnyiq ptkfvsfefs aqknrsyvis sftelkaydl lskasvqfvd ynkrqmsriy
      601 pkgtrmdssn ympqmfwnag cqmvalnfqt mdlpmqqnma vfefngqsgy llkhefmrrp
      661 dkqfnpfsvd ridvvvattl sitvisgqfl sersvrtyve velfglpgdp krryrtklsp
      721 stnsinpvwk eepfvfekil mpelaslrva vmeegnkflg hriipinaln sgyhhlclhs
      781 esnmpltmpa lfiflemkdy ipgawadltv alanpikffs ahdtksvklk eamgglpekp
      841 fplaspvasq vngalaptsn gsparagare eamkeaaepr tasleelrel kgvvklqrrh
      901 ekelrelerr garrweellq rgaaqlaelg ppgvggvgac klgpgkgsrk krslpreesa
      961 gaapgegpeg vdgrvrelkd rlelellrqg eeqyecvlkr keqhvaeqis kmmelarekq
     1021 aaelkalket sendtkemkk kletkrleri qgmtkvttdk maqerlkrei nnshiqevvq
     1081 vikqmtenle rhqekleekq aacleqirem ekqfqkeala eyearmkgle aevkesvrac
     1141 lrtcfpseak dkperacecp pelceqdpli akadaqesrl
//
LOCUS       XP_047288632            1177 aa            linear   PRI 05-AUG-2025
DEFINITION  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
            isoform X12 [Homo sapiens].
ACCESSION   XP_047288632
VERSION     XP_047288632.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432676.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1177
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1177
                     /product="1-phosphatidylinositol 4,5-bisphosphate
                     phosphodiesterase beta-2 isoform X12"
                     /calculated_mol_wt=133063
     Region          12..141
                     /region_name="PH_14"
                     /note="PH domain; pfam17787"
                     /db_xref="CDD:465506"
     Region          149..299
                     /region_name="EFh_PI-PLCbeta2"
                     /note="EF-hand motif found in phosphoinositide
                     phospholipase C beta 2 (PI-PLC-beta2); cd16209"
                     /db_xref="CDD:320039"
     Region          149..178
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          182..211
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          220..249
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          266..299
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          311..649
                     /region_name="PI-PLCc_beta2"
                     /note="Catalytic domain of metazoan
                     phosphoinositide-specific phospholipase C-beta2; cd08624"
                     /db_xref="CDD:176561"
     Site            order(327..328,357,359,374,408,461,463,575,602,604)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:176561"
     Site            order(327,374)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:176561"
     Site            order(328,357,359,408)
                     /site_type="other"
                     /note="Ca binding site [ion binding]"
                     /db_xref="CDD:176561"
     Region          681..802
                     /region_name="C2_PLC_like"
                     /note="C2 domain present in Phosphoinositide-specific
                     phospholipases C (PLC); cd00275"
                     /db_xref="CDD:175974"
     Site            order(700,725,757,761,763)
                     /site_type="other"
                     /note="Ca2+ binding pocket [ion binding]"
                     /db_xref="CDD:175974"
     Region          963..1145
                     /region_name="PLC-beta_C"
                     /note="PLC-beta C terminal; pfam08703"
                     /db_xref="CDD:462571"
     CDS             1..1177
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /coded_by="XM_047432676.1:264..3797"
                     /db_xref="GeneID:5330"
                     /db_xref="HGNC:HGNC:9055"
                     /db_xref="MIM:604114"
ORIGIN      
        1 msllnpvllp pkvkaylsqg erfikwddet tvaspvilrv dpkgyylywt yqskemefld
       61 itsirdtrfg kfakmpksqk lrdvfnmdfp dnsfllktlt vvsgpdmvdl tfhnfvsyke
      121 nvgkawaedv lalvkhplta nasrstfldk ilvklkmqln segkipvknf fqmfpadrkr
      181 veaalsachl pkgkndainp edfpepvyks flmslcprpe ideiftsyha kakpymtkeh
      241 ltkfinqkqr dsrlnsllfp parpdqvqgl idkyepsgin aqrgqlspeg mvwflcgpen
      301 svlaqdklll hhdmtqplnh yfinsshnty ltagqfsgls saemyrqvll sgcrcveldc
      361 wkgkppdeep iithgftmtt diffkeaiea iaesafktsp ypiilsfenh vdsprqqakm
      421 aeycrtifgd mllteplekf plkpgvplps pedlrgkili knkknqfsgp tssskdtgge
      481 aegssppsap agegtvwage egteleeeev eeeeeeesgn ldeeeikkmq sdegtaglev
      541 tayeemsslv nyiqptkfvs fefsaqknrs yvissftelk aydllskasv qfvdynkrqm
      601 sriypkgtrm dssnympqmf wnagcqmval nfqtmdlpmq qnmavfefng qsgyllkhef
      661 mrrpdkqfnp fsvdridvvv attlsitvis gqflsersvr tyvevelfgl pgdpkrryrt
      721 klspstnsin pvwkeepfvf ekilmpelas lrvavmeegn kflghriipi nalnsgyhhl
      781 clhsesnmpl tmpalfifle mkdyipgawa dltvalanpi kffsahdtks vklkeamggl
      841 pekpfplasp vasqvngala ptsngspepr tasleelrel kgvvklqrrh ekelrelerr
      901 garrweellq rgaaqlaelg ppgvggvgac klgpgkgsrk krslpreesa gaapgegpeg
      961 vdgrvrelkd rlelellrqg eeqyecvlkr keqhvaeqis kmmelarekq aaelkalket
     1021 sendtkemkk kletkrleri qgmtkvttdk maqerlkrei nnshiqevvq vikqmtenle
     1081 rhqekleekq aacleqirem ekqgsllspq fqkealaeye armkgleaev kesvraclrt
     1141 cfpseakdkp eracecppel ceqdpliaka daqesrl
//
LOCUS       XP_047288633            1173 aa            linear   PRI 05-AUG-2025
DEFINITION  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
            isoform X13 [Homo sapiens].
ACCESSION   XP_047288633
VERSION     XP_047288633.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432677.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1173
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1173
                     /product="1-phosphatidylinositol 4,5-bisphosphate
                     phosphodiesterase beta-2 isoform X13"
                     /calculated_mol_wt=132719
     Region          12..141
                     /region_name="PH_14"
                     /note="PH domain; pfam17787"
                     /db_xref="CDD:465506"
     Region          149..299
                     /region_name="EFh_PI-PLCbeta2"
                     /note="EF-hand motif found in phosphoinositide
                     phospholipase C beta 2 (PI-PLC-beta2); cd16209"
                     /db_xref="CDD:320039"
     Region          149..178
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          182..211
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          220..249
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          266..299
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          311..645
                     /region_name="PI-PLCc_beta2"
                     /note="Catalytic domain of metazoan
                     phosphoinositide-specific phospholipase C-beta2; cd08624"
                     /db_xref="CDD:176561"
     Site            order(327..328,357,359,374,408,461,463,571,598,600)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:176561"
     Site            order(327,374)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:176561"
     Site            order(328,357,359,408)
                     /site_type="other"
                     /note="Ca binding site [ion binding]"
                     /db_xref="CDD:176561"
     Region          677..798
                     /region_name="C2_PLC_like"
                     /note="C2 domain present in Phosphoinositide-specific
                     phospholipases C (PLC); cd00275"
                     /db_xref="CDD:175974"
     Site            order(696,721,753,757,759)
                     /site_type="other"
                     /note="Ca2+ binding pocket [ion binding]"
                     /db_xref="CDD:175974"
     Region          959..1141
                     /region_name="PLC-beta_C"
                     /note="PLC-beta C terminal; pfam08703"
                     /db_xref="CDD:462571"
     CDS             1..1173
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /coded_by="XM_047432677.1:264..3785"
                     /db_xref="GeneID:5330"
                     /db_xref="HGNC:HGNC:9055"
                     /db_xref="MIM:604114"
ORIGIN      
        1 msllnpvllp pkvkaylsqg erfikwddet tvaspvilrv dpkgyylywt yqskemefld
       61 itsirdtrfg kfakmpksqk lrdvfnmdfp dnsfllktlt vvsgpdmvdl tfhnfvsyke
      121 nvgkawaedv lalvkhplta nasrstfldk ilvklkmqln segkipvknf fqmfpadrkr
      181 veaalsachl pkgkndainp edfpepvyks flmslcprpe ideiftsyha kakpymtkeh
      241 ltkfinqkqr dsrlnsllfp parpdqvqgl idkyepsgin aqrgqlspeg mvwflcgpen
      301 svlaqdklll hhdmtqplnh yfinsshnty ltagqfsgls saemyrqvll sgcrcveldc
      361 wkgkppdeep iithgftmtt diffkeaiea iaesafktsp ypiilsfenh vdsprqqakm
      421 aeycrtifgd mllteplekf plkpgvplps pedlrgkili knkknqfsgp tssskdtgge
      481 aegssppsap avwageegte leeeeveeee eeesgnldee eikkmqsdeg taglevtaye
      541 emsslvnyiq ptkfvsfefs aqknrsyvis sftelkaydl lskasvqfvd ynkrqmsriy
      601 pkgtrmdssn ympqmfwnag cqmvalnfqt mdlpmqqnma vfefngqsgy llkhefmrrp
      661 dkqfnpfsvd ridvvvattl sitvisgqfl sersvrtyve velfglpgdp krryrtklsp
      721 stnsinpvwk eepfvfekil mpelaslrva vmeegnkflg hriipinaln sgyhhlclhs
      781 esnmpltmpa lfiflemkdy ipgawadltv alanpikffs ahdtksvklk eamgglpekp
      841 fplaspvasq vngalaptsn gspeprtasl eelrelkgvv klqrrhekel relerrgarr
      901 weellqrgaa qlaelgppgv ggvgacklgp gkgsrkkrsl preesagaap gegpegvdgr
      961 vrelkdrlel ellrqgeeqy ecvlkrkeqh vaeqiskmme larekqaael kalketsend
     1021 tkemkkklet krleriqgmt kvttdkmaqe rlkreinnsh iqevvqvikq mtenlerhqe
     1081 kleekqaacl eqiremekqg sllspqfqke alaeyearmk gleaevkesv raclrtcfps
     1141 eakdkperac ecppelceqd pliakadaqe srl
//
LOCUS       XP_047288634            1166 aa            linear   PRI 05-AUG-2025
DEFINITION  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
            isoform X14 [Homo sapiens].
ACCESSION   XP_047288634
VERSION     XP_047288634.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432678.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1166
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1166
                     /product="1-phosphatidylinositol 4,5-bisphosphate
                     phosphodiesterase beta-2 isoform X14"
                     /calculated_mol_wt=132036
     Region          12..141
                     /region_name="PH_14"
                     /note="PH domain; pfam17787"
                     /db_xref="CDD:465506"
     Region          149..299
                     /region_name="EFh_PI-PLCbeta2"
                     /note="EF-hand motif found in phosphoinositide
                     phospholipase C beta 2 (PI-PLC-beta2); cd16209"
                     /db_xref="CDD:320039"
     Region          149..178
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          182..211
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          220..249
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          266..299
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          311..645
                     /region_name="PI-PLCc_beta2"
                     /note="Catalytic domain of metazoan
                     phosphoinositide-specific phospholipase C-beta2; cd08624"
                     /db_xref="CDD:176561"
     Site            order(327..328,357,359,374,408,461,463,571,598,600)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:176561"
     Site            order(327,374)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:176561"
     Site            order(328,357,359,408)
                     /site_type="other"
                     /note="Ca binding site [ion binding]"
                     /db_xref="CDD:176561"
     Region          677..798
                     /region_name="C2_PLC_like"
                     /note="C2 domain present in Phosphoinositide-specific
                     phospholipases C (PLC); cd00275"
                     /db_xref="CDD:175974"
     Site            order(696,721,753,757,759)
                     /site_type="other"
                     /note="Ca2+ binding pocket [ion binding]"
                     /db_xref="CDD:175974"
     Region          959..1134
                     /region_name="PLC-beta_C"
                     /note="PLC-beta C terminal; pfam08703"
                     /db_xref="CDD:462571"
     CDS             1..1166
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /coded_by="XM_047432678.1:264..3764"
                     /db_xref="GeneID:5330"
                     /db_xref="HGNC:HGNC:9055"
                     /db_xref="MIM:604114"
ORIGIN      
        1 msllnpvllp pkvkaylsqg erfikwddet tvaspvilrv dpkgyylywt yqskemefld
       61 itsirdtrfg kfakmpksqk lrdvfnmdfp dnsfllktlt vvsgpdmvdl tfhnfvsyke
      121 nvgkawaedv lalvkhplta nasrstfldk ilvklkmqln segkipvknf fqmfpadrkr
      181 veaalsachl pkgkndainp edfpepvyks flmslcprpe ideiftsyha kakpymtkeh
      241 ltkfinqkqr dsrlnsllfp parpdqvqgl idkyepsgin aqrgqlspeg mvwflcgpen
      301 svlaqdklll hhdmtqplnh yfinsshnty ltagqfsgls saemyrqvll sgcrcveldc
      361 wkgkppdeep iithgftmtt diffkeaiea iaesafktsp ypiilsfenh vdsprqqakm
      421 aeycrtifgd mllteplekf plkpgvplps pedlrgkili knkknqfsgp tssskdtgge
      481 aegssppsap avwageegte leeeeveeee eeesgnldee eikkmqsdeg taglevtaye
      541 emsslvnyiq ptkfvsfefs aqknrsyvis sftelkaydl lskasvqfvd ynkrqmsriy
      601 pkgtrmdssn ympqmfwnag cqmvalnfqt mdlpmqqnma vfefngqsgy llkhefmrrp
      661 dkqfnpfsvd ridvvvattl sitvisgqfl sersvrtyve velfglpgdp krryrtklsp
      721 stnsinpvwk eepfvfekil mpelaslrva vmeegnkflg hriipinaln sgyhhlclhs
      781 esnmpltmpa lfiflemkdy ipgawadltv alanpikffs ahdtksvklk eamgglpekp
      841 fplaspvasq vngalaptsn gspeprtasl eelrelkgvv klqrrhekel relerrgarr
      901 weellqrgaa qlaelgppgv ggvgacklgp gkgsrkkrsl preesagaap gegpegvdgr
      961 vrelkdrlel ellrqgeeqy ecvlkrkeqh vaeqiskmme larekqaael kalketsend
     1021 tkemkkklet krleriqgmt kvttdkmaqe rlkreinnsh iqevvqvikq mtenlerhqe
     1081 kleekqaacl eqiremekqf qkealaeyea rmkgleaevk esvraclrtc fpseakdkpe
     1141 racecppelc eqdpliakad aqesrl
//
LOCUS       XP_047288635            1137 aa            linear   PRI 05-AUG-2025
DEFINITION  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
            isoform X15 [Homo sapiens].
ACCESSION   XP_047288635
VERSION     XP_047288635.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432679.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1137
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1137
                     /product="1-phosphatidylinositol 4,5-bisphosphate
                     phosphodiesterase beta-2 isoform X15"
                     /calculated_mol_wt=128494
     Region          12..141
                     /region_name="PH_14"
                     /note="PH domain; pfam17787"
                     /db_xref="CDD:465506"
     Region          149..299
                     /region_name="EFh_PI-PLCbeta2"
                     /note="EF-hand motif found in phosphoinositide
                     phospholipase C beta 2 (PI-PLC-beta2); cd16209"
                     /db_xref="CDD:320039"
     Region          149..178
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          182..211
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          220..249
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          266..299
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          311..662
                     /region_name="PI-PLCc_beta2"
                     /note="Catalytic domain of metazoan
                     phosphoinositide-specific phospholipase C-beta2; cd08624"
                     /db_xref="CDD:176561"
     Site            order(327..328,357,359,374,408,461,463,588,615,617)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:176561"
     Site            order(327,374)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:176561"
     Site            order(328,357,359,408)
                     /site_type="other"
                     /note="Ca binding site [ion binding]"
                     /db_xref="CDD:176561"
     Region          694..815
                     /region_name="C2_PLC_like"
                     /note="C2 domain present in Phosphoinositide-specific
                     phospholipases C (PLC); cd00275"
                     /db_xref="CDD:175974"
     Site            order(713,738,770,774,776)
                     /site_type="other"
                     /note="Ca2+ binding pocket [ion binding]"
                     /db_xref="CDD:175974"
     Region          892..>1087
                     /region_name="YhaN"
                     /note="Uncharacterized conserved protein YhaN, contains
                     AAA domain [Function unknown]; COG4717"
                     /db_xref="CDD:443752"
     Region          991..>1131
                     /region_name="PLC-beta_C"
                     /note="PLC-beta C terminal; pfam08703"
                     /db_xref="CDD:462571"
     CDS             1..1137
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /coded_by="XM_047432679.1:264..3677"
                     /db_xref="GeneID:5330"
                     /db_xref="HGNC:HGNC:9055"
                     /db_xref="MIM:604114"
ORIGIN      
        1 msllnpvllp pkvkaylsqg erfikwddet tvaspvilrv dpkgyylywt yqskemefld
       61 itsirdtrfg kfakmpksqk lrdvfnmdfp dnsfllktlt vvsgpdmvdl tfhnfvsyke
      121 nvgkawaedv lalvkhplta nasrstfldk ilvklkmqln segkipvknf fqmfpadrkr
      181 veaalsachl pkgkndainp edfpepvyks flmslcprpe ideiftsyha kakpymtkeh
      241 ltkfinqkqr dsrlnsllfp parpdqvqgl idkyepsgin aqrgqlspeg mvwflcgpen
      301 svlaqdklll hhdmtqplnh yfinsshnty ltagqfsgls saemyrqvll sgcrcveldc
      361 wkgkppdeep iithgftmtt diffkeaiea iaesafktsp ypiilsfenh vdsprqqakm
      421 aeycrtifgd mllteplekf plkpgvplps pedlrgkili knkknqfsgp tssskdtgge
      481 aegssppsap agegtvwage egteleeeev eeeeeeesgn ldeeeikkmq sdegtaglev
      541 tayeemsslv nyiqptkfvs fefsaprlft cifsghkhkk nrsyvissft elkaydllsk
      601 asvqfvdynk rqmsriypkg trmdssnymp qmfwnagcqm valnfqtmdl pmqqnmavfe
      661 fngqsgyllk hefmrrpdkq fnpfsvdrid vvvattlsit visgqflser svrtyvevel
      721 fglpgdpkrr yrtklspstn sinpvwkeep fvfekilmpe laslrvavme egnkflghri
      781 ipinalnsgy hhlclhsesn mpltmpalfi flemkdyipg awadltvala npikffsahd
      841 tksvklkeam gglpekpfpl aspvasqvng alaptsngsp aaragareea mkeaaeprta
      901 sleelrelkg vvklqrrhek elrelerrga rrweellqrg aaqlaelgpp gvggvgackl
      961 gpgkgsrkkr slpreesaga apgegpegvd grvrelkdrl elellrqgee qyecvlkrke
     1021 qhvaeqiskm melarekqaa elkalketse ndtkemkkkl etkrleriqg mtkvttdkma
     1081 qerlkreinn shiqevvqvi kqmtenlerh qekleekqaa cleqiremek qpdpahp
//
LOCUS       XP_016877808            1136 aa            linear   PRI 05-AUG-2025
DEFINITION  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
            isoform X16 [Homo sapiens].
ACCESSION   XP_016877808
VERSION     XP_016877808.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022319.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1136
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1136
                     /product="1-phosphatidylinositol 4,5-bisphosphate
                     phosphodiesterase beta-2 isoform X16"
                     /calculated_mol_wt=128404
     Region          12..141
                     /region_name="PH_14"
                     /note="PH domain; pfam17787"
                     /db_xref="CDD:465506"
     Region          149..299
                     /region_name="EFh_PI-PLCbeta2"
                     /note="EF-hand motif found in phosphoinositide
                     phospholipase C beta 2 (PI-PLC-beta2); cd16209"
                     /db_xref="CDD:320039"
     Region          149..178
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          182..211
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          220..249
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          266..299
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          311..662
                     /region_name="PI-PLCc_beta2"
                     /note="Catalytic domain of metazoan
                     phosphoinositide-specific phospholipase C-beta2; cd08624"
                     /db_xref="CDD:176561"
     Site            order(327..328,357,359,374,408,461,463,588,615,617)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:176561"
     Site            order(327,374)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:176561"
     Site            order(328,357,359,408)
                     /site_type="other"
                     /note="Ca binding site [ion binding]"
                     /db_xref="CDD:176561"
     Region          694..815
                     /region_name="C2_PLC_like"
                     /note="C2 domain present in Phosphoinositide-specific
                     phospholipases C (PLC); cd00275"
                     /db_xref="CDD:175974"
     Site            order(713,738,770,774,776)
                     /site_type="other"
                     /note="Ca2+ binding pocket [ion binding]"
                     /db_xref="CDD:175974"
     Region          892..>1087
                     /region_name="YhaN"
                     /note="Uncharacterized conserved protein YhaN, contains
                     AAA domain [Function unknown]; COG4717"
                     /db_xref="CDD:443752"
     Region          991..1132
                     /region_name="PLC-beta_C"
                     /note="PLC-beta C terminal; pfam08703"
                     /db_xref="CDD:462571"
     CDS             1..1136
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /coded_by="XM_017022319.3:264..3674"
                     /db_xref="GeneID:5330"
                     /db_xref="HGNC:HGNC:9055"
                     /db_xref="MIM:604114"
ORIGIN      
        1 msllnpvllp pkvkaylsqg erfikwddet tvaspvilrv dpkgyylywt yqskemefld
       61 itsirdtrfg kfakmpksqk lrdvfnmdfp dnsfllktlt vvsgpdmvdl tfhnfvsyke
      121 nvgkawaedv lalvkhplta nasrstfldk ilvklkmqln segkipvknf fqmfpadrkr
      181 veaalsachl pkgkndainp edfpepvyks flmslcprpe ideiftsyha kakpymtkeh
      241 ltkfinqkqr dsrlnsllfp parpdqvqgl idkyepsgin aqrgqlspeg mvwflcgpen
      301 svlaqdklll hhdmtqplnh yfinsshnty ltagqfsgls saemyrqvll sgcrcveldc
      361 wkgkppdeep iithgftmtt diffkeaiea iaesafktsp ypiilsfenh vdsprqqakm
      421 aeycrtifgd mllteplekf plkpgvplps pedlrgkili knkknqfsgp tssskdtgge
      481 aegssppsap agegtvwage egteleeeev eeeeeeesgn ldeeeikkmq sdegtaglev
      541 tayeemsslv nyiqptkfvs fefsaprlft cifsghkhkk nrsyvissft elkaydllsk
      601 asvqfvdynk rqmsriypkg trmdssnymp qmfwnagcqm valnfqtmdl pmqqnmavfe
      661 fngqsgyllk hefmrrpdkq fnpfsvdrid vvvattlsit visgqflser svrtyvevel
      721 fglpgdpkrr yrtklspstn sinpvwkeep fvfekilmpe laslrvavme egnkflghri
      781 ipinalnsgy hhlclhsesn mpltmpalfi flemkdyipg awadltvala npikffsahd
      841 tksvklkeam gglpekpfpl aspvasqvng alaptsngsp aaragareea mkeaaeprta
      901 sleelrelkg vvklqrrhek elrelerrga rrweellqrg aaqlaelgpp gvggvgackl
      961 gpgkgsrkkr slpreesaga apgegpegvd grvrelkdrl elellrqgee qyecvlkrke
     1021 qhvaeqiskm melarekqaa elkalketse ndtkemkkkl etkrleriqg mtkvttdkma
     1081 qerlkreinn shiqevvqvi kqmtenlerh qekleekqaa cleqiremek qnilsp
//
LOCUS       XP_047288636            1124 aa            linear   PRI 05-AUG-2025
DEFINITION  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
            isoform X17 [Homo sapiens].
ACCESSION   XP_047288636
VERSION     XP_047288636.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432680.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1124
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1124
                     /product="1-phosphatidylinositol 4,5-bisphosphate
                     phosphodiesterase beta-2 isoform X17"
                     /calculated_mol_wt=126969
     Region          12..141
                     /region_name="PH_14"
                     /note="PH domain; pfam17787"
                     /db_xref="CDD:465506"
     Region          149..299
                     /region_name="EFh_PI-PLCbeta2"
                     /note="EF-hand motif found in phosphoinositide
                     phospholipase C beta 2 (PI-PLC-beta2); cd16209"
                     /db_xref="CDD:320039"
     Region          149..178
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          182..211
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          220..249
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          266..299
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          311..649
                     /region_name="PI-PLCc_beta2"
                     /note="Catalytic domain of metazoan
                     phosphoinositide-specific phospholipase C-beta2; cd08624"
                     /db_xref="CDD:176561"
     Site            order(327..328,357,359,374,408,461,463,575,602,604)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:176561"
     Site            order(327,374)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:176561"
     Site            order(328,357,359,408)
                     /site_type="other"
                     /note="Ca binding site [ion binding]"
                     /db_xref="CDD:176561"
     Region          681..802
                     /region_name="C2_PLC_like"
                     /note="C2 domain present in Phosphoinositide-specific
                     phospholipases C (PLC); cd00275"
                     /db_xref="CDD:175974"
     Site            order(700,725,757,761,763)
                     /site_type="other"
                     /note="Ca2+ binding pocket [ion binding]"
                     /db_xref="CDD:175974"
     Region          879..>1074
                     /region_name="YhaN"
                     /note="Uncharacterized conserved protein YhaN, contains
                     AAA domain [Function unknown]; COG4717"
                     /db_xref="CDD:443752"
     Region          978..>1118
                     /region_name="PLC-beta_C"
                     /note="PLC-beta C terminal; pfam08703"
                     /db_xref="CDD:462571"
     CDS             1..1124
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /coded_by="XM_047432680.1:264..3638"
                     /db_xref="GeneID:5330"
                     /db_xref="HGNC:HGNC:9055"
                     /db_xref="MIM:604114"
ORIGIN      
        1 msllnpvllp pkvkaylsqg erfikwddet tvaspvilrv dpkgyylywt yqskemefld
       61 itsirdtrfg kfakmpksqk lrdvfnmdfp dnsfllktlt vvsgpdmvdl tfhnfvsyke
      121 nvgkawaedv lalvkhplta nasrstfldk ilvklkmqln segkipvknf fqmfpadrkr
      181 veaalsachl pkgkndainp edfpepvyks flmslcprpe ideiftsyha kakpymtkeh
      241 ltkfinqkqr dsrlnsllfp parpdqvqgl idkyepsgin aqrgqlspeg mvwflcgpen
      301 svlaqdklll hhdmtqplnh yfinsshnty ltagqfsgls saemyrqvll sgcrcveldc
      361 wkgkppdeep iithgftmtt diffkeaiea iaesafktsp ypiilsfenh vdsprqqakm
      421 aeycrtifgd mllteplekf plkpgvplps pedlrgkili knkknqfsgp tssskdtgge
      481 aegssppsap agegtvwage egteleeeev eeeeeeesgn ldeeeikkmq sdegtaglev
      541 tayeemsslv nyiqptkfvs fefsaqknrs yvissftelk aydllskasv qfvdynkrqm
      601 sriypkgtrm dssnympqmf wnagcqmval nfqtmdlpmq qnmavfefng qsgyllkhef
      661 mrrpdkqfnp fsvdridvvv attlsitvis gqflsersvr tyvevelfgl pgdpkrryrt
      721 klspstnsin pvwkeepfvf ekilmpelas lrvavmeegn kflghriipi nalnsgyhhl
      781 clhsesnmpl tmpalfifle mkdyipgawa dltvalanpi kffsahdtks vklkeamggl
      841 pekpfplasp vasqvngala ptsngspaar agareeamke aaeprtasle elrelkgvvk
      901 lqrrhekelr elerrgarrw eellqrgaaq laelgppgvg gvgacklgpg kgsrkkrslp
      961 reesagaapg egpegvdgrv relkdrlele llrqgeeqye cvlkrkeqhv aeqiskmmel
     1021 arekqaaelk alketsendt kemkkkletk rleriqgmtk vttdkmaqer lkreinnshi
     1081 qevvqvikqm tenlerhqek leekqaacle qiremekqpd pahp
//
LOCUS       XP_047288637            1123 aa            linear   PRI 05-AUG-2025
DEFINITION  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
            isoform X18 [Homo sapiens].
ACCESSION   XP_047288637
VERSION     XP_047288637.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432681.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1123
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1123
                     /product="1-phosphatidylinositol 4,5-bisphosphate
                     phosphodiesterase beta-2 isoform X18"
                     /calculated_mol_wt=126879
     Region          12..141
                     /region_name="PH_14"
                     /note="PH domain; pfam17787"
                     /db_xref="CDD:465506"
     Region          149..299
                     /region_name="EFh_PI-PLCbeta2"
                     /note="EF-hand motif found in phosphoinositide
                     phospholipase C beta 2 (PI-PLC-beta2); cd16209"
                     /db_xref="CDD:320039"
     Region          149..178
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          182..211
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          220..249
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          266..299
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          311..649
                     /region_name="PI-PLCc_beta2"
                     /note="Catalytic domain of metazoan
                     phosphoinositide-specific phospholipase C-beta2; cd08624"
                     /db_xref="CDD:176561"
     Site            order(327..328,357,359,374,408,461,463,575,602,604)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:176561"
     Site            order(327,374)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:176561"
     Site            order(328,357,359,408)
                     /site_type="other"
                     /note="Ca binding site [ion binding]"
                     /db_xref="CDD:176561"
     Region          681..802
                     /region_name="C2_PLC_like"
                     /note="C2 domain present in Phosphoinositide-specific
                     phospholipases C (PLC); cd00275"
                     /db_xref="CDD:175974"
     Site            order(700,725,757,761,763)
                     /site_type="other"
                     /note="Ca2+ binding pocket [ion binding]"
                     /db_xref="CDD:175974"
     Region          879..>1074
                     /region_name="YhaN"
                     /note="Uncharacterized conserved protein YhaN, contains
                     AAA domain [Function unknown]; COG4717"
                     /db_xref="CDD:443752"
     Region          978..1119
                     /region_name="PLC-beta_C"
                     /note="PLC-beta C terminal; pfam08703"
                     /db_xref="CDD:462571"
     CDS             1..1123
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /coded_by="XM_047432681.1:264..3635"
                     /db_xref="GeneID:5330"
                     /db_xref="HGNC:HGNC:9055"
                     /db_xref="MIM:604114"
ORIGIN      
        1 msllnpvllp pkvkaylsqg erfikwddet tvaspvilrv dpkgyylywt yqskemefld
       61 itsirdtrfg kfakmpksqk lrdvfnmdfp dnsfllktlt vvsgpdmvdl tfhnfvsyke
      121 nvgkawaedv lalvkhplta nasrstfldk ilvklkmqln segkipvknf fqmfpadrkr
      181 veaalsachl pkgkndainp edfpepvyks flmslcprpe ideiftsyha kakpymtkeh
      241 ltkfinqkqr dsrlnsllfp parpdqvqgl idkyepsgin aqrgqlspeg mvwflcgpen
      301 svlaqdklll hhdmtqplnh yfinsshnty ltagqfsgls saemyrqvll sgcrcveldc
      361 wkgkppdeep iithgftmtt diffkeaiea iaesafktsp ypiilsfenh vdsprqqakm
      421 aeycrtifgd mllteplekf plkpgvplps pedlrgkili knkknqfsgp tssskdtgge
      481 aegssppsap agegtvwage egteleeeev eeeeeeesgn ldeeeikkmq sdegtaglev
      541 tayeemsslv nyiqptkfvs fefsaqknrs yvissftelk aydllskasv qfvdynkrqm
      601 sriypkgtrm dssnympqmf wnagcqmval nfqtmdlpmq qnmavfefng qsgyllkhef
      661 mrrpdkqfnp fsvdridvvv attlsitvis gqflsersvr tyvevelfgl pgdpkrryrt
      721 klspstnsin pvwkeepfvf ekilmpelas lrvavmeegn kflghriipi nalnsgyhhl
      781 clhsesnmpl tmpalfifle mkdyipgawa dltvalanpi kffsahdtks vklkeamggl
      841 pekpfplasp vasqvngala ptsngspaar agareeamke aaeprtasle elrelkgvvk
      901 lqrrhekelr elerrgarrw eellqrgaaq laelgppgvg gvgacklgpg kgsrkkrslp
      961 reesagaapg egpegvdgrv relkdrlele llrqgeeqye cvlkrkeqhv aeqiskmmel
     1021 arekqaaelk alketsendt kemkkkletk rleriqgmtk vttdkmaqer lkreinnshi
     1081 qevvqvikqm tenlerhqek leekqaacle qiremekqni lsp
//
LOCUS       XP_047288638            1123 aa            linear   PRI 05-AUG-2025
DEFINITION  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
            isoform X19 [Homo sapiens].
ACCESSION   XP_047288638
VERSION     XP_047288638.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432682.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1123
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1123
                     /product="1-phosphatidylinositol 4,5-bisphosphate
                     phosphodiesterase beta-2 isoform X19"
                     /calculated_mol_wt=126898
     Region          12..141
                     /region_name="PH_14"
                     /note="PH domain; pfam17787"
                     /db_xref="CDD:465506"
     Region          149..299
                     /region_name="EFh_PI-PLCbeta2"
                     /note="EF-hand motif found in phosphoinositide
                     phospholipase C beta 2 (PI-PLC-beta2); cd16209"
                     /db_xref="CDD:320039"
     Region          149..178
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          182..211
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          220..249
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          266..299
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          311..649
                     /region_name="PI-PLCc_beta2"
                     /note="Catalytic domain of metazoan
                     phosphoinositide-specific phospholipase C-beta2; cd08624"
                     /db_xref="CDD:176561"
     Site            order(327..328,357,359,374,408,461,463,575,602,604)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:176561"
     Site            order(327,374)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:176561"
     Site            order(328,357,359,408)
                     /site_type="other"
                     /note="Ca binding site [ion binding]"
                     /db_xref="CDD:176561"
     Region          681..802
                     /region_name="C2_PLC_like"
                     /note="C2 domain present in Phosphoinositide-specific
                     phospholipases C (PLC); cd00275"
                     /db_xref="CDD:175974"
     Site            order(700,725,757,761,763)
                     /site_type="other"
                     /note="Ca2+ binding pocket [ion binding]"
                     /db_xref="CDD:175974"
     Region          872..>1073
                     /region_name="YhaN"
                     /note="Uncharacterized conserved protein YhaN, contains
                     AAA domain [Function unknown]; COG4717"
                     /db_xref="CDD:443752"
     Region          977..>1117
                     /region_name="PLC-beta_C"
                     /note="PLC-beta C terminal; pfam08703"
                     /db_xref="CDD:462571"
     CDS             1..1123
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /coded_by="XM_047432682.1:264..3635"
                     /db_xref="GeneID:5330"
                     /db_xref="HGNC:HGNC:9055"
                     /db_xref="MIM:604114"
ORIGIN      
        1 msllnpvllp pkvkaylsqg erfikwddet tvaspvilrv dpkgyylywt yqskemefld
       61 itsirdtrfg kfakmpksqk lrdvfnmdfp dnsfllktlt vvsgpdmvdl tfhnfvsyke
      121 nvgkawaedv lalvkhplta nasrstfldk ilvklkmqln segkipvknf fqmfpadrkr
      181 veaalsachl pkgkndainp edfpepvyks flmslcprpe ideiftsyha kakpymtkeh
      241 ltkfinqkqr dsrlnsllfp parpdqvqgl idkyepsgin aqrgqlspeg mvwflcgpen
      301 svlaqdklll hhdmtqplnh yfinsshnty ltagqfsgls saemyrqvll sgcrcveldc
      361 wkgkppdeep iithgftmtt diffkeaiea iaesafktsp ypiilsfenh vdsprqqakm
      421 aeycrtifgd mllteplekf plkpgvplps pedlrgkili knkknqfsgp tssskdtgge
      481 aegssppsap agegtvwage egteleeeev eeeeeeesgn ldeeeikkmq sdegtaglev
      541 tayeemsslv nyiqptkfvs fefsaqknrs yvissftelk aydllskasv qfvdynkrqm
      601 sriypkgtrm dssnympqmf wnagcqmval nfqtmdlpmq qnmavfefng qsgyllkhef
      661 mrrpdkqfnp fsvdridvvv attlsitvis gqflsersvr tyvevelfgl pgdpkrryrt
      721 klspstnsin pvwkeepfvf ekilmpelas lrvavmeegn kflghriipi nalnsgyhhl
      781 clhsesnmpl tmpalfifle mkdyipgawa dltvalanpi kffsahdtks vklkeamggl
      841 pekpfplasp vasqvngala ptsngspara gareeamkea aeprtaslee lrelkgvvkl
      901 qrrhekelre lerrgarrwe ellqrgaaql aelgppgvgg vgacklgpgk gsrkkrslpr
      961 eesagaapge gpegvdgrvr elkdrlelel lrqgeeqyec vlkrkeqhva eqiskmmela
     1021 rekqaaelka lketsendtk emkkkletkr leriqgmtkv ttdkmaqerl kreinnshiq
     1081 evvqvikqmt enlerhqekl eekqaacleq iremekqpdp ahp
//
LOCUS       XP_047288639            1121 aa            linear   PRI 05-AUG-2025
DEFINITION  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
            isoform X20 [Homo sapiens].
ACCESSION   XP_047288639
VERSION     XP_047288639.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432683.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1121
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1121
                     /product="1-phosphatidylinositol 4,5-bisphosphate
                     phosphodiesterase beta-2 isoform X20"
                     /calculated_mol_wt=126890
     Region          12..141
                     /region_name="PH_14"
                     /note="PH domain; pfam17787"
                     /db_xref="CDD:465506"
     Region          149..299
                     /region_name="EFh_PI-PLCbeta2"
                     /note="EF-hand motif found in phosphoinositide
                     phospholipase C beta 2 (PI-PLC-beta2); cd16209"
                     /db_xref="CDD:320039"
     Region          149..178
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          182..211
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          220..249
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          266..299
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          311..662
                     /region_name="PI-PLCc_beta2"
                     /note="Catalytic domain of metazoan
                     phosphoinositide-specific phospholipase C-beta2; cd08624"
                     /db_xref="CDD:176561"
     Site            order(327..328,357,359,374,408,461,463,588,615,617)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:176561"
     Site            order(327,374)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:176561"
     Site            order(328,357,359,408)
                     /site_type="other"
                     /note="Ca binding site [ion binding]"
                     /db_xref="CDD:176561"
     Region          694..815
                     /region_name="C2_PLC_like"
                     /note="C2 domain present in Phosphoinositide-specific
                     phospholipases C (PLC); cd00275"
                     /db_xref="CDD:175974"
     Site            order(713,738,770,774,776)
                     /site_type="other"
                     /note="Ca2+ binding pocket [ion binding]"
                     /db_xref="CDD:175974"
     Region          976..1117
                     /region_name="PLC-beta_C"
                     /note="PLC-beta C terminal; pfam08703"
                     /db_xref="CDD:462571"
     CDS             1..1121
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /coded_by="XM_047432683.1:264..3629"
                     /db_xref="GeneID:5330"
                     /db_xref="HGNC:HGNC:9055"
                     /db_xref="MIM:604114"
ORIGIN      
        1 msllnpvllp pkvkaylsqg erfikwddet tvaspvilrv dpkgyylywt yqskemefld
       61 itsirdtrfg kfakmpksqk lrdvfnmdfp dnsfllktlt vvsgpdmvdl tfhnfvsyke
      121 nvgkawaedv lalvkhplta nasrstfldk ilvklkmqln segkipvknf fqmfpadrkr
      181 veaalsachl pkgkndainp edfpepvyks flmslcprpe ideiftsyha kakpymtkeh
      241 ltkfinqkqr dsrlnsllfp parpdqvqgl idkyepsgin aqrgqlspeg mvwflcgpen
      301 svlaqdklll hhdmtqplnh yfinsshnty ltagqfsgls saemyrqvll sgcrcveldc
      361 wkgkppdeep iithgftmtt diffkeaiea iaesafktsp ypiilsfenh vdsprqqakm
      421 aeycrtifgd mllteplekf plkpgvplps pedlrgkili knkknqfsgp tssskdtgge
      481 aegssppsap agegtvwage egteleeeev eeeeeeesgn ldeeeikkmq sdegtaglev
      541 tayeemsslv nyiqptkfvs fefsaprlft cifsghkhkk nrsyvissft elkaydllsk
      601 asvqfvdynk rqmsriypkg trmdssnymp qmfwnagcqm valnfqtmdl pmqqnmavfe
      661 fngqsgyllk hefmrrpdkq fnpfsvdrid vvvattlsit visgqflser svrtyvevel
      721 fglpgdpkrr yrtklspstn sinpvwkeep fvfekilmpe laslrvavme egnkflghri
      781 ipinalnsgy hhlclhsesn mpltmpalfi flemkdyipg awadltvala npikffsahd
      841 tksvklkeam gglpekpfpl aspvasqvng alaptsngsp eprtasleel relkgvvklq
      901 rrhekelrel errgarrwee llqrgaaqla elgppgvggv gacklgpgkg srkkrslpre
      961 esagaapgeg pegvdgrvre lkdrlelell rqgeeqyecv lkrkeqhvae qiskmmelar
     1021 ekqaaelkal ketsendtke mkkkletkrl eriqgmtkvt tdkmaqerlk reinnshiqe
     1081 vvqvikqmte nlerhqekle ekqaacleqi remekqnils p
//
LOCUS       XP_047288640            1109 aa            linear   PRI 05-AUG-2025
DEFINITION  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
            isoform X21 [Homo sapiens].
ACCESSION   XP_047288640
VERSION     XP_047288640.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432684.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1109
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1109
                     /product="1-phosphatidylinositol 4,5-bisphosphate
                     phosphodiesterase beta-2 isoform X21"
                     /calculated_mol_wt=125455
     Region          12..141
                     /region_name="PH_14"
                     /note="PH domain; pfam17787"
                     /db_xref="CDD:465506"
     Region          149..299
                     /region_name="EFh_PI-PLCbeta2"
                     /note="EF-hand motif found in phosphoinositide
                     phospholipase C beta 2 (PI-PLC-beta2); cd16209"
                     /db_xref="CDD:320039"
     Region          149..178
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          182..211
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          220..249
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          266..299
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          311..649
                     /region_name="PI-PLCc_beta2"
                     /note="Catalytic domain of metazoan
                     phosphoinositide-specific phospholipase C-beta2; cd08624"
                     /db_xref="CDD:176561"
     Site            order(327..328,357,359,374,408,461,463,575,602,604)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:176561"
     Site            order(327,374)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:176561"
     Site            order(328,357,359,408)
                     /site_type="other"
                     /note="Ca binding site [ion binding]"
                     /db_xref="CDD:176561"
     Region          681..802
                     /region_name="C2_PLC_like"
                     /note="C2 domain present in Phosphoinositide-specific
                     phospholipases C (PLC); cd00275"
                     /db_xref="CDD:175974"
     Site            order(700,725,757,761,763)
                     /site_type="other"
                     /note="Ca2+ binding pocket [ion binding]"
                     /db_xref="CDD:175974"
     Region          963..>1103
                     /region_name="PLC-beta_C"
                     /note="PLC-beta C terminal; pfam08703"
                     /db_xref="CDD:462571"
     CDS             1..1109
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /coded_by="XM_047432684.1:264..3593"
                     /db_xref="GeneID:5330"
                     /db_xref="HGNC:HGNC:9055"
                     /db_xref="MIM:604114"
ORIGIN      
        1 msllnpvllp pkvkaylsqg erfikwddet tvaspvilrv dpkgyylywt yqskemefld
       61 itsirdtrfg kfakmpksqk lrdvfnmdfp dnsfllktlt vvsgpdmvdl tfhnfvsyke
      121 nvgkawaedv lalvkhplta nasrstfldk ilvklkmqln segkipvknf fqmfpadrkr
      181 veaalsachl pkgkndainp edfpepvyks flmslcprpe ideiftsyha kakpymtkeh
      241 ltkfinqkqr dsrlnsllfp parpdqvqgl idkyepsgin aqrgqlspeg mvwflcgpen
      301 svlaqdklll hhdmtqplnh yfinsshnty ltagqfsgls saemyrqvll sgcrcveldc
      361 wkgkppdeep iithgftmtt diffkeaiea iaesafktsp ypiilsfenh vdsprqqakm
      421 aeycrtifgd mllteplekf plkpgvplps pedlrgkili knkknqfsgp tssskdtgge
      481 aegssppsap agegtvwage egteleeeev eeeeeeesgn ldeeeikkmq sdegtaglev
      541 tayeemsslv nyiqptkfvs fefsaqknrs yvissftelk aydllskasv qfvdynkrqm
      601 sriypkgtrm dssnympqmf wnagcqmval nfqtmdlpmq qnmavfefng qsgyllkhef
      661 mrrpdkqfnp fsvdridvvv attlsitvis gqflsersvr tyvevelfgl pgdpkrryrt
      721 klspstnsin pvwkeepfvf ekilmpelas lrvavmeegn kflghriipi nalnsgyhhl
      781 clhsesnmpl tmpalfifle mkdyipgawa dltvalanpi kffsahdtks vklkeamggl
      841 pekpfplasp vasqvngala ptsngspepr tasleelrel kgvvklqrrh ekelrelerr
      901 garrweellq rgaaqlaelg ppgvggvgac klgpgkgsrk krslpreesa gaapgegpeg
      961 vdgrvrelkd rlelellrqg eeqyecvlkr keqhvaeqis kmmelarekq aaelkalket
     1021 sendtkemkk kletkrleri qgmtkvttdk maqerlkrei nnshiqevvq vikqmtenle
     1081 rhqekleekq aacleqirem ekqpdpahp
//
LOCUS       XP_047288641            1108 aa            linear   PRI 05-AUG-2025
DEFINITION  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
            isoform X22 [Homo sapiens].
ACCESSION   XP_047288641
VERSION     XP_047288641.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432685.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1108
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1108
                     /product="1-phosphatidylinositol 4,5-bisphosphate
                     phosphodiesterase beta-2 isoform X22"
                     /calculated_mol_wt=125365
     Region          12..141
                     /region_name="PH_14"
                     /note="PH domain; pfam17787"
                     /db_xref="CDD:465506"
     Region          149..299
                     /region_name="EFh_PI-PLCbeta2"
                     /note="EF-hand motif found in phosphoinositide
                     phospholipase C beta 2 (PI-PLC-beta2); cd16209"
                     /db_xref="CDD:320039"
     Region          149..178
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          182..211
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          220..249
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          266..299
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          311..649
                     /region_name="PI-PLCc_beta2"
                     /note="Catalytic domain of metazoan
                     phosphoinositide-specific phospholipase C-beta2; cd08624"
                     /db_xref="CDD:176561"
     Site            order(327..328,357,359,374,408,461,463,575,602,604)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:176561"
     Site            order(327,374)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:176561"
     Site            order(328,357,359,408)
                     /site_type="other"
                     /note="Ca binding site [ion binding]"
                     /db_xref="CDD:176561"
     Region          681..802
                     /region_name="C2_PLC_like"
                     /note="C2 domain present in Phosphoinositide-specific
                     phospholipases C (PLC); cd00275"
                     /db_xref="CDD:175974"
     Site            order(700,725,757,761,763)
                     /site_type="other"
                     /note="Ca2+ binding pocket [ion binding]"
                     /db_xref="CDD:175974"
     Region          963..1104
                     /region_name="PLC-beta_C"
                     /note="PLC-beta C terminal; pfam08703"
                     /db_xref="CDD:462571"
     CDS             1..1108
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /coded_by="XM_047432685.1:264..3590"
                     /db_xref="GeneID:5330"
                     /db_xref="HGNC:HGNC:9055"
                     /db_xref="MIM:604114"
ORIGIN      
        1 msllnpvllp pkvkaylsqg erfikwddet tvaspvilrv dpkgyylywt yqskemefld
       61 itsirdtrfg kfakmpksqk lrdvfnmdfp dnsfllktlt vvsgpdmvdl tfhnfvsyke
      121 nvgkawaedv lalvkhplta nasrstfldk ilvklkmqln segkipvknf fqmfpadrkr
      181 veaalsachl pkgkndainp edfpepvyks flmslcprpe ideiftsyha kakpymtkeh
      241 ltkfinqkqr dsrlnsllfp parpdqvqgl idkyepsgin aqrgqlspeg mvwflcgpen
      301 svlaqdklll hhdmtqplnh yfinsshnty ltagqfsgls saemyrqvll sgcrcveldc
      361 wkgkppdeep iithgftmtt diffkeaiea iaesafktsp ypiilsfenh vdsprqqakm
      421 aeycrtifgd mllteplekf plkpgvplps pedlrgkili knkknqfsgp tssskdtgge
      481 aegssppsap agegtvwage egteleeeev eeeeeeesgn ldeeeikkmq sdegtaglev
      541 tayeemsslv nyiqptkfvs fefsaqknrs yvissftelk aydllskasv qfvdynkrqm
      601 sriypkgtrm dssnympqmf wnagcqmval nfqtmdlpmq qnmavfefng qsgyllkhef
      661 mrrpdkqfnp fsvdridvvv attlsitvis gqflsersvr tyvevelfgl pgdpkrryrt
      721 klspstnsin pvwkeepfvf ekilmpelas lrvavmeegn kflghriipi nalnsgyhhl
      781 clhsesnmpl tmpalfifle mkdyipgawa dltvalanpi kffsahdtks vklkeamggl
      841 pekpfplasp vasqvngala ptsngspepr tasleelrel kgvvklqrrh ekelrelerr
      901 garrweellq rgaaqlaelg ppgvggvgac klgpgkgsrk krslpreesa gaapgegpeg
      961 vdgrvrelkd rlelellrqg eeqyecvlkr keqhvaeqis kmmelarekq aaelkalket
     1021 sendtkemkk kletkrleri qgmtkvttdk maqerlkrei nnshiqevvq vikqmtenle
     1081 rhqekleekq aacleqirem ekqnilsp
//
LOCUS       XP_047288642            1104 aa            linear   PRI 05-AUG-2025
DEFINITION  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
            isoform X23 [Homo sapiens].
ACCESSION   XP_047288642
VERSION     XP_047288642.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432686.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1104
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1104
                     /product="1-phosphatidylinositol 4,5-bisphosphate
                     phosphodiesterase beta-2 isoform X23"
                     /calculated_mol_wt=125021
     Region          12..141
                     /region_name="PH_14"
                     /note="PH domain; pfam17787"
                     /db_xref="CDD:465506"
     Region          149..299
                     /region_name="EFh_PI-PLCbeta2"
                     /note="EF-hand motif found in phosphoinositide
                     phospholipase C beta 2 (PI-PLC-beta2); cd16209"
                     /db_xref="CDD:320039"
     Region          149..178
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          182..211
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          220..249
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          266..299
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          311..645
                     /region_name="PI-PLCc_beta2"
                     /note="Catalytic domain of metazoan
                     phosphoinositide-specific phospholipase C-beta2; cd08624"
                     /db_xref="CDD:176561"
     Site            order(327..328,357,359,374,408,461,463,571,598,600)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:176561"
     Site            order(327,374)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:176561"
     Site            order(328,357,359,408)
                     /site_type="other"
                     /note="Ca binding site [ion binding]"
                     /db_xref="CDD:176561"
     Region          677..798
                     /region_name="C2_PLC_like"
                     /note="C2 domain present in Phosphoinositide-specific
                     phospholipases C (PLC); cd00275"
                     /db_xref="CDD:175974"
     Site            order(696,721,753,757,759)
                     /site_type="other"
                     /note="Ca2+ binding pocket [ion binding]"
                     /db_xref="CDD:175974"
     Region          959..1100
                     /region_name="PLC-beta_C"
                     /note="PLC-beta C terminal; pfam08703"
                     /db_xref="CDD:462571"
     CDS             1..1104
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /coded_by="XM_047432686.1:264..3578"
                     /db_xref="GeneID:5330"
                     /db_xref="HGNC:HGNC:9055"
                     /db_xref="MIM:604114"
ORIGIN      
        1 msllnpvllp pkvkaylsqg erfikwddet tvaspvilrv dpkgyylywt yqskemefld
       61 itsirdtrfg kfakmpksqk lrdvfnmdfp dnsfllktlt vvsgpdmvdl tfhnfvsyke
      121 nvgkawaedv lalvkhplta nasrstfldk ilvklkmqln segkipvknf fqmfpadrkr
      181 veaalsachl pkgkndainp edfpepvyks flmslcprpe ideiftsyha kakpymtkeh
      241 ltkfinqkqr dsrlnsllfp parpdqvqgl idkyepsgin aqrgqlspeg mvwflcgpen
      301 svlaqdklll hhdmtqplnh yfinsshnty ltagqfsgls saemyrqvll sgcrcveldc
      361 wkgkppdeep iithgftmtt diffkeaiea iaesafktsp ypiilsfenh vdsprqqakm
      421 aeycrtifgd mllteplekf plkpgvplps pedlrgkili knkknqfsgp tssskdtgge
      481 aegssppsap avwageegte leeeeveeee eeesgnldee eikkmqsdeg taglevtaye
      541 emsslvnyiq ptkfvsfefs aqknrsyvis sftelkaydl lskasvqfvd ynkrqmsriy
      601 pkgtrmdssn ympqmfwnag cqmvalnfqt mdlpmqqnma vfefngqsgy llkhefmrrp
      661 dkqfnpfsvd ridvvvattl sitvisgqfl sersvrtyve velfglpgdp krryrtklsp
      721 stnsinpvwk eepfvfekil mpelaslrva vmeegnkflg hriipinaln sgyhhlclhs
      781 esnmpltmpa lfiflemkdy ipgawadltv alanpikffs ahdtksvklk eamgglpekp
      841 fplaspvasq vngalaptsn gspeprtasl eelrelkgvv klqrrhekel relerrgarr
      901 weellqrgaa qlaelgppgv ggvgacklgp gkgsrkkrsl preesagaap gegpegvdgr
      961 vrelkdrlel ellrqgeeqy ecvlkrkeqh vaeqiskmme larekqaael kalketsend
     1021 tkemkkklet krleriqgmt kvttdkmaqe rlkreinnsh iqevvqvikq mtenlerhqe
     1081 kleekqaacl eqiremekqn ilsp
//
LOCUS       XP_047288643            1083 aa            linear   PRI 05-AUG-2025
DEFINITION  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
            isoform X24 [Homo sapiens].
ACCESSION   XP_047288643
VERSION     XP_047288643.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432687.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1083
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1083
                     /product="1-phosphatidylinositol 4,5-bisphosphate
                     phosphodiesterase beta-2 isoform X24"
                     /calculated_mol_wt=122066
     Region          12..141
                     /region_name="PH_14"
                     /note="PH domain; pfam17787"
                     /db_xref="CDD:465506"
     Region          149..299
                     /region_name="EFh_PI-PLCbeta2"
                     /note="EF-hand motif found in phosphoinositide
                     phospholipase C beta 2 (PI-PLC-beta2); cd16209"
                     /db_xref="CDD:320039"
     Region          149..178
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          182..211
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          220..249
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          266..299
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          311..662
                     /region_name="PI-PLCc_beta2"
                     /note="Catalytic domain of metazoan
                     phosphoinositide-specific phospholipase C-beta2; cd08624"
                     /db_xref="CDD:176561"
     Site            order(327..328,357,359,374,408,461,463,588,615,617)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:176561"
     Site            order(327,374)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:176561"
     Site            order(328,357,359,408)
                     /site_type="other"
                     /note="Ca binding site [ion binding]"
                     /db_xref="CDD:176561"
     Region          694..815
                     /region_name="C2_PLC_like"
                     /note="C2 domain present in Phosphoinositide-specific
                     phospholipases C (PLC); cd00275"
                     /db_xref="CDD:175974"
     Site            order(713,738,770,774,776)
                     /site_type="other"
                     /note="Ca2+ binding pocket [ion binding]"
                     /db_xref="CDD:175974"
     Region          <903..1077
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          991..>1083
                     /region_name="PLC-beta_C"
                     /note="PLC-beta C terminal; pfam08703"
                     /db_xref="CDD:462571"
     CDS             1..1083
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /coded_by="XM_047432687.1:264..3515"
                     /db_xref="GeneID:5330"
                     /db_xref="HGNC:HGNC:9055"
                     /db_xref="MIM:604114"
ORIGIN      
        1 msllnpvllp pkvkaylsqg erfikwddet tvaspvilrv dpkgyylywt yqskemefld
       61 itsirdtrfg kfakmpksqk lrdvfnmdfp dnsfllktlt vvsgpdmvdl tfhnfvsyke
      121 nvgkawaedv lalvkhplta nasrstfldk ilvklkmqln segkipvknf fqmfpadrkr
      181 veaalsachl pkgkndainp edfpepvyks flmslcprpe ideiftsyha kakpymtkeh
      241 ltkfinqkqr dsrlnsllfp parpdqvqgl idkyepsgin aqrgqlspeg mvwflcgpen
      301 svlaqdklll hhdmtqplnh yfinsshnty ltagqfsgls saemyrqvll sgcrcveldc
      361 wkgkppdeep iithgftmtt diffkeaiea iaesafktsp ypiilsfenh vdsprqqakm
      421 aeycrtifgd mllteplekf plkpgvplps pedlrgkili knkknqfsgp tssskdtgge
      481 aegssppsap agegtvwage egteleeeev eeeeeeesgn ldeeeikkmq sdegtaglev
      541 tayeemsslv nyiqptkfvs fefsaprlft cifsghkhkk nrsyvissft elkaydllsk
      601 asvqfvdynk rqmsriypkg trmdssnymp qmfwnagcqm valnfqtmdl pmqqnmavfe
      661 fngqsgyllk hefmrrpdkq fnpfsvdrid vvvattlsit visgqflser svrtyvevel
      721 fglpgdpkrr yrtklspstn sinpvwkeep fvfekilmpe laslrvavme egnkflghri
      781 ipinalnsgy hhlclhsesn mpltmpalfi flemkdyipg awadltvala npikffsahd
      841 tksvklkeam gglpekpfpl aspvasqvng alaptsngsp aaragareea mkeaaeprta
      901 sleelrelkg vvklqrrhek elrelerrga rrweellqrg aaqlaelgpp gvggvgackl
      961 gpgkgsrkkr slpreesaga apgegpegvd grvrelkdrl elellrqgee qyecvlkrke
     1021 qhvaeqiskm melarekqaa elkalketse ndtkemkkkl etkrleriqg mtkvttdkma
     1081 qer
//
LOCUS       XP_047288644            1024 aa            linear   PRI 05-AUG-2025
DEFINITION  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
            isoform X25 [Homo sapiens].
ACCESSION   XP_047288644
VERSION     XP_047288644.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432688.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1024
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1024
                     /product="1-phosphatidylinositol 4,5-bisphosphate
                     phosphodiesterase beta-2 isoform X25"
                     /calculated_mol_wt=113260
     Region          12..141
                     /region_name="PH_14"
                     /note="PH domain; pfam17787"
                     /db_xref="CDD:465506"
     Region          149..299
                     /region_name="EFh_PI-PLCbeta2"
                     /note="EF-hand motif found in phosphoinositide
                     phospholipase C beta 2 (PI-PLC-beta2); cd16209"
                     /db_xref="CDD:320039"
     Region          149..178
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          182..211
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          220..249
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          266..299
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320039"
     Region          311..662
                     /region_name="PI-PLCc_beta2"
                     /note="Catalytic domain of metazoan
                     phosphoinositide-specific phospholipase C-beta2; cd08624"
                     /db_xref="CDD:176561"
     Site            order(327..328,357,359,374,408,461,463,588,615,617)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:176561"
     Site            order(327,374)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:176561"
     Site            order(328,357,359,408)
                     /site_type="other"
                     /note="Ca binding site [ion binding]"
                     /db_xref="CDD:176561"
     Region          694..815
                     /region_name="C2_PLC_like"
                     /note="C2 domain present in Phosphoinositide-specific
                     phospholipases C (PLC); cd00275"
                     /db_xref="CDD:175974"
     Site            order(713,738,770,774,776)
                     /site_type="other"
                     /note="Ca2+ binding pocket [ion binding]"
                     /db_xref="CDD:175974"
     CDS             1..1024
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /coded_by="XM_047432688.1:264..3338"
                     /db_xref="GeneID:5330"
                     /db_xref="HGNC:HGNC:9055"
                     /db_xref="MIM:604114"
ORIGIN      
        1 msllnpvllp pkvkaylsqg erfikwddet tvaspvilrv dpkgyylywt yqskemefld
       61 itsirdtrfg kfakmpksqk lrdvfnmdfp dnsfllktlt vvsgpdmvdl tfhnfvsyke
      121 nvgkawaedv lalvkhplta nasrstfldk ilvklkmqln segkipvknf fqmfpadrkr
      181 veaalsachl pkgkndainp edfpepvyks flmslcprpe ideiftsyha kakpymtkeh
      241 ltkfinqkqr dsrlnsllfp parpdqvqgl idkyepsgin aqrgqlspeg mvwflcgpen
      301 svlaqdklll hhdmtqplnh yfinsshnty ltagqfsgls saemyrqvll sgcrcveldc
      361 wkgkppdeep iithgftmtt diffkeaiea iaesafktsp ypiilsfenh vdsprqqakm
      421 aeycrtifgd mllteplekf plkpgvplps pedlrgkili knkknqfsgp tssskdtgge
      481 aegssppsap agegtvwage egteleeeev eeeeeeesgn ldeeeikkmq sdegtaglev
      541 tayeemsslv nyiqptkfvs fefsaprlft cifsghkhkk nrsyvissft elkaydllsk
      601 asvqfvdynk rqmsriypkg trmdssnymp qmfwnagcqm valnfqtmdl pmqqnmavfe
      661 fngqsgyllk hefmrrpdkq fnpfsvdrid vvvattlsit visgqflser svrtyvevel
      721 fglpgdpkrr yrtklspstn sinpvwkeep fvfekilmpe laslrvavme egnkflghri
      781 ipinalnsgy hhlclhsesn mpltmpalfi flemkdyipg awadltvala npikffsahd
      841 tksvklkeam gglpekpfpl aspvasqvng alaptsngsp gkvrgrghil rlpgggveea
      901 ngakgpprap dspargscss qgrgqgrgye rscgaadrqp ggapgakgrg eaaaaarega
      961 arvgaarsaa lggaaaagrg aaggaratgr ggrrglqars rqglsqeeep aprgerrsra
     1021 grgp
//
LOCUS       XP_047288645             215 aa            linear   PRI 05-AUG-2025
DEFINITION  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
            isoform X26 [Homo sapiens].
ACCESSION   XP_047288645
VERSION     XP_047288645.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432689.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..215
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..215
                     /product="1-phosphatidylinositol 4,5-bisphosphate
                     phosphodiesterase beta-2 isoform X26"
                     /calculated_mol_wt=24449
     Region          12..141
                     /region_name="PH_14"
                     /note="PH domain; pfam17787"
                     /db_xref="CDD:465506"
     Region          149..>194
                     /region_name="EFh_PI-PLC"
                     /note="EF-hand motif found in eukaryotic
                     phosphoinositide-specific phospholipase C (PI-PLC, EC
                     3.1.4.11) isozymes; cl28895"
                     /db_xref="CDD:333715"
     Region          149..178
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320029"
     CDS             1..215
                     /gene="PLCB2"
                     /gene_synonym="PLC-beta-2"
                     /coded_by="XM_047432689.1:264..911"
                     /db_xref="GeneID:5330"
                     /db_xref="HGNC:HGNC:9055"
                     /db_xref="MIM:604114"
ORIGIN      
        1 msllnpvllp pkvkaylsqg erfikwddet tvaspvilrv dpkgyylywt yqskemefld
       61 itsirdtrfg kfakmpksqk lrdvfnmdfp dnsfllktlt vvsgpdmvdl tfhnfvsyke
      121 nvgkawaedv lalvkhplta nasrstfldk ilvklkmqln segkipvknf fqmfpadrkr
      181 veaalsachl pkgkfrscps qwnshctksg seqts
//
LOCUS       XP_011519981             373 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane 6 superfamily member 1 isoform X1 [Homo sapiens].
ACCESSION   XP_011519981
VERSION     XP_011519981.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521679.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..373
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..373
                     /product="transmembrane 6 superfamily member 1 isoform X1"
                     /calculated_mol_wt=41946
     Region          6..307
                     /region_name="TM6SF1-like"
                     /note="transmembrane 6 superfamily member 1, member 2, and
                     similar proteins; cd21106"
                     /db_xref="CDD:411047"
     CDS             1..373
                     /gene="TM6SF1"
                     /coded_by="XM_011521679.3:37..1158"
                     /db_xref="GeneID:53346"
                     /db_xref="HGNC:HGNC:11860"
                     /db_xref="MIM:606562"
ORIGIN      
        1 msasaatgvf vlslsaipvt yvfnhlaaqh dswtivgvaa lilflvalla rvlvkrkppr
       61 dplfyvyavf gftsvvnlii gleqdgiidg fmthylrege pylntayghm icywdgsahy
      121 lmylvmvaai aweetyrtig lywvgsiims vvvfvpgniv gkygtricpa fflsipytcl
      181 pvwagfriyn qpsenynyps kviqeaqakd llrrpfdlml vvclllatgf clfrgliald
      241 cpselcrlyt qfqepylkdp aaypkiqmla ymfysvpyfv talyglvvpg cswmpditli
      301 hagglaqffr rhfckyilfq shnnymvdvp ssytdeevic gpvklndlpk vthpacgivv
      361 lldcftisey hgy
//
LOCUS       XP_047288646            1551 aa            linear   PRI 05-AUG-2025
DEFINITION  dual oxidase 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047288646
VERSION     XP_047288646.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432690.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1551
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1551
                     /product="dual oxidase 1 isoform X1"
                     /calculated_mol_wt=177105
     Region          32..591
                     /region_name="dual_peroxidase_like"
                     /note="Dual oxidase and related animal heme peroxidases;
                     cd09820"
                     /db_xref="CDD:188652"
     Site            order(241..242,324,327..329,331,334,367,419,422,426)
                     /site_type="other"
                     /note="putative heme binding site [chemical binding]"
                     /db_xref="CDD:188652"
     Site            order(292,295..296,300,323,327,329,493,497,501..502,
                     505..506,509)
                     /site_type="other"
                     /note="putative substrate binding site [chemical binding]"
                     /db_xref="CDD:188652"
     Region          820..881
                     /region_name="EFh"
                     /note="EF-hand, calcium binding motif; A diverse
                     superfamily of calcium sensors and calcium signal
                     modulators; most examples in this alignment model have 2
                     active canonical EF hands. Ca2+ binding induces a
                     conformational change in the EF-hand motif, leading to...;
                     cd00051"
                     /db_xref="CDD:238008"
     Site            order(828,830,832,839,864,866,868,875)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238008"
     Region          857..915
                     /region_name="EFh"
                     /note="EF-hand, calcium binding motif; A diverse
                     superfamily of calcium sensors and calcium signal
                     modulators; most examples in this alignment model have 2
                     active canonical EF hands. Ca2+ binding induces a
                     conformational change in the EF-hand motif, leading to...;
                     cd00051"
                     /db_xref="CDD:238008"
     Region          1089..>1412
                     /region_name="PLN02292"
                     /note="ferric-chelate reductase"
                     /db_xref="CDD:215165"
     Region          1277..1551
                     /region_name="NOX_Duox_like_FAD_NADP"
                     /note="NADPH oxidase (NOX) catalyzes the generation of
                     reactive oxygen species (ROS) such as superoxide and
                     hydrogen peroxide. ROS were originally identified as
                     bactericidal agents in phagocytes, but are now also
                     implicated in cell signaling and metabolism. NOX...;
                     cd06186"
                     /db_xref="CDD:99783"
     Site            order(1305,1319..1322,1335..1337,1340..1343,1390)
                     /site_type="other"
                     /note="FAD binding pocket [chemical binding]"
                     /db_xref="CDD:99783"
     Site            order(1319,1321..1322)
                     /site_type="other"
                     /note="FAD binding motif [chemical binding]"
                     /db_xref="CDD:99783"
     Site            1385..1395
                     /site_type="other"
                     /note="NAD pyrophosphate binding region [chemical
                     binding]"
                     /db_xref="CDD:99783"
     Site            order(1385,1389..1392,1394)
                     /site_type="other"
                     /note="beta-alpha-beta stucture motif"
                     /db_xref="CDD:99783"
     Site            order(1390..1391,1422..1424,1521..1522)
                     /site_type="other"
                     /note="NAD binding pocket [chemical binding]"
                     /db_xref="CDD:99783"
     Site            order(1420..1421,1424)
                     /site_type="other"
                     /note="NADP ribose binding motif [chemical binding]"
                     /db_xref="CDD:99783"
     CDS             1..1551
                     /gene="DUOX1"
                     /gene_synonym="LNOX1; NOXEF1; THOX1"
                     /coded_by="XM_047432690.1:1974..6629"
                     /db_xref="GeneID:53905"
                     /db_xref="HGNC:HGNC:3062"
                     /db_xref="MIM:606758"
ORIGIN      
        1 mgfclalawt llvgawtplg aqnpiswevq rfdgwynnlm ehrwgskgsr lqrlvpasya
       61 dgvyqplgep hlpnprdlsn tisrgpagla slrnrtvlgv ffgyhvlsdl vsvetpgcpa
      121 eflnirippg dpmfdpdqrg dvvlpfqrsr wdpetgrsps nprdpanqvt gwldgsaiyg
      181 sshswsdalr sfsrgqlasg pdpafprdsq npllmwaapd patgqngprg lyafgaergn
      241 repflqalgl lwfryhnlwa qrlarqhpdw edeelfqhar krviatyqni avyewlpsfl
      301 qktlpeytgy rpfldpsiss efvaaseqfl stmvppgvym rnaschfqgv inrnssvsra
      361 lrvcnsywsr ehpslqsaed vdalllgmas qiaeredhvl vedvrdfwpg plkfsrtdhl
      421 asclqrgrdl glpsytkara alglspitrw qdinpalsrs ndtvleataa lynqdlswle
      481 llpggllesh rdpgplfsti vleqfvrlrd gdrywfentr nglfskkeie eirnttlqdv
      541 lvavinidps alqpnvfvwh kgdpcpqprq lsteglpaca psvvrdyfeg sgfgfgvtig
      601 tlccfplvsl lsawivarlr mrnfkrlqgq drqsivsekl vggmealewq ghkepcrpvl
      661 vylqpgqirv vdgrltvlrt iqlqppqkvn fvlssnrgrr tlllkipkey dlvllfnlee
      721 erqalvenlr galkesglsi qewelreqel mraavtreqr rhlletffrh lfsqvldinq
      781 adagtlplds sqkvrealtc elsraefaes lglkpqdmfv esmfsladkd gngylsfref
      841 ldilvvfmkg speeksrlmf rmydfdgngl iskdefirml rsfieisnnc lskaqlaevv
      901 esmfresgfq dkeeltwedf hfmlrdhnse lrftqlcvkg vevpevikdl crrasyisqd
      961 micpsprvsa rcsrsdiete ltpqrlqcpm dtdppqeirr rfgkkvtsfq pllfteahre
     1021 kfqrsclhqt vqqfkrfien yrrhigcvav fyaiagglfl erayyyafaa hhtgitdttr
     1081 vgiilsrgta asisfmfsyi lltmcrnlit flretflnry vpfdaavdfh rliastaivl
     1141 tvlhsvghvv nvylfsispl svlsclfpgl fhddgselpq kyywwffqtv pgltgvvlll
     1201 ilaimyvfas hhfrrrsfrg fwlthhlyil lyvlliihgs faliqlprfh ifflvpaiiy
     1261 ggdklvslsr kkveisvvka ellpsgvthl rfqrpqgfey ksgqwvriac lalgtteyhp
     1321 ftltsaphed tlslhiraag pwttrlreiy saptgdrcar ypklyldgpf geghqewhkf
     1381 evsvlvgggi gvtpfasilk dlvfkssvsc qvfckkiyfi wvtrtqrqfe wladiireve
     1441 endhqdlvsv hiyitqlaek fdlrttmlyi cerhfqkvln rslftglrsi thfgrppfep
     1501 ffnslqevhp qvrkigvfsc gppgmtknve kacqlinrqd rthfshhyen f
//
LOCUS       XP_047288647            1551 aa            linear   PRI 05-AUG-2025
DEFINITION  dual oxidase 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047288647
VERSION     XP_047288647.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432691.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1551
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1551
                     /product="dual oxidase 1 isoform X1"
                     /calculated_mol_wt=177105
     Region          32..591
                     /region_name="dual_peroxidase_like"
                     /note="Dual oxidase and related animal heme peroxidases;
                     cd09820"
                     /db_xref="CDD:188652"
     Site            order(241..242,324,327..329,331,334,367,419,422,426)
                     /site_type="other"
                     /note="putative heme binding site [chemical binding]"
                     /db_xref="CDD:188652"
     Site            order(292,295..296,300,323,327,329,493,497,501..502,
                     505..506,509)
                     /site_type="other"
                     /note="putative substrate binding site [chemical binding]"
                     /db_xref="CDD:188652"
     Region          820..881
                     /region_name="EFh"
                     /note="EF-hand, calcium binding motif; A diverse
                     superfamily of calcium sensors and calcium signal
                     modulators; most examples in this alignment model have 2
                     active canonical EF hands. Ca2+ binding induces a
                     conformational change in the EF-hand motif, leading to...;
                     cd00051"
                     /db_xref="CDD:238008"
     Site            order(828,830,832,839,864,866,868,875)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238008"
     Region          857..915
                     /region_name="EFh"
                     /note="EF-hand, calcium binding motif; A diverse
                     superfamily of calcium sensors and calcium signal
                     modulators; most examples in this alignment model have 2
                     active canonical EF hands. Ca2+ binding induces a
                     conformational change in the EF-hand motif, leading to...;
                     cd00051"
                     /db_xref="CDD:238008"
     Region          1089..>1412
                     /region_name="PLN02292"
                     /note="ferric-chelate reductase"
                     /db_xref="CDD:215165"
     Region          1277..1551
                     /region_name="NOX_Duox_like_FAD_NADP"
                     /note="NADPH oxidase (NOX) catalyzes the generation of
                     reactive oxygen species (ROS) such as superoxide and
                     hydrogen peroxide. ROS were originally identified as
                     bactericidal agents in phagocytes, but are now also
                     implicated in cell signaling and metabolism. NOX...;
                     cd06186"
                     /db_xref="CDD:99783"
     Site            order(1305,1319..1322,1335..1337,1340..1343,1390)
                     /site_type="other"
                     /note="FAD binding pocket [chemical binding]"
                     /db_xref="CDD:99783"
     Site            order(1319,1321..1322)
                     /site_type="other"
                     /note="FAD binding motif [chemical binding]"
                     /db_xref="CDD:99783"
     Site            1385..1395
                     /site_type="other"
                     /note="NAD pyrophosphate binding region [chemical
                     binding]"
                     /db_xref="CDD:99783"
     Site            order(1385,1389..1392,1394)
                     /site_type="other"
                     /note="beta-alpha-beta stucture motif"
                     /db_xref="CDD:99783"
     Site            order(1390..1391,1422..1424,1521..1522)
                     /site_type="other"
                     /note="NAD binding pocket [chemical binding]"
                     /db_xref="CDD:99783"
     Site            order(1420..1421,1424)
                     /site_type="other"
                     /note="NADP ribose binding motif [chemical binding]"
                     /db_xref="CDD:99783"
     CDS             1..1551
                     /gene="DUOX1"
                     /gene_synonym="LNOX1; NOXEF1; THOX1"
                     /coded_by="XM_047432691.1:602..5257"
                     /db_xref="GeneID:53905"
                     /db_xref="HGNC:HGNC:3062"
                     /db_xref="MIM:606758"
ORIGIN      
        1 mgfclalawt llvgawtplg aqnpiswevq rfdgwynnlm ehrwgskgsr lqrlvpasya
       61 dgvyqplgep hlpnprdlsn tisrgpagla slrnrtvlgv ffgyhvlsdl vsvetpgcpa
      121 eflnirippg dpmfdpdqrg dvvlpfqrsr wdpetgrsps nprdpanqvt gwldgsaiyg
      181 sshswsdalr sfsrgqlasg pdpafprdsq npllmwaapd patgqngprg lyafgaergn
      241 repflqalgl lwfryhnlwa qrlarqhpdw edeelfqhar krviatyqni avyewlpsfl
      301 qktlpeytgy rpfldpsiss efvaaseqfl stmvppgvym rnaschfqgv inrnssvsra
      361 lrvcnsywsr ehpslqsaed vdalllgmas qiaeredhvl vedvrdfwpg plkfsrtdhl
      421 asclqrgrdl glpsytkara alglspitrw qdinpalsrs ndtvleataa lynqdlswle
      481 llpggllesh rdpgplfsti vleqfvrlrd gdrywfentr nglfskkeie eirnttlqdv
      541 lvavinidps alqpnvfvwh kgdpcpqprq lsteglpaca psvvrdyfeg sgfgfgvtig
      601 tlccfplvsl lsawivarlr mrnfkrlqgq drqsivsekl vggmealewq ghkepcrpvl
      661 vylqpgqirv vdgrltvlrt iqlqppqkvn fvlssnrgrr tlllkipkey dlvllfnlee
      721 erqalvenlr galkesglsi qewelreqel mraavtreqr rhlletffrh lfsqvldinq
      781 adagtlplds sqkvrealtc elsraefaes lglkpqdmfv esmfsladkd gngylsfref
      841 ldilvvfmkg speeksrlmf rmydfdgngl iskdefirml rsfieisnnc lskaqlaevv
      901 esmfresgfq dkeeltwedf hfmlrdhnse lrftqlcvkg vevpevikdl crrasyisqd
      961 micpsprvsa rcsrsdiete ltpqrlqcpm dtdppqeirr rfgkkvtsfq pllfteahre
     1021 kfqrsclhqt vqqfkrfien yrrhigcvav fyaiagglfl erayyyafaa hhtgitdttr
     1081 vgiilsrgta asisfmfsyi lltmcrnlit flretflnry vpfdaavdfh rliastaivl
     1141 tvlhsvghvv nvylfsispl svlsclfpgl fhddgselpq kyywwffqtv pgltgvvlll
     1201 ilaimyvfas hhfrrrsfrg fwlthhlyil lyvlliihgs faliqlprfh ifflvpaiiy
     1261 ggdklvslsr kkveisvvka ellpsgvthl rfqrpqgfey ksgqwvriac lalgtteyhp
     1321 ftltsaphed tlslhiraag pwttrlreiy saptgdrcar ypklyldgpf geghqewhkf
     1381 evsvlvgggi gvtpfasilk dlvfkssvsc qvfckkiyfi wvtrtqrqfe wladiireve
     1441 endhqdlvsv hiyitqlaek fdlrttmlyi cerhfqkvln rslftglrsi thfgrppfep
     1501 ffnslqevhp qvrkigvfsc gppgmtknve kacqlinrqd rthfshhyen f
//
LOCUS       XP_047288648            1551 aa            linear   PRI 05-AUG-2025
DEFINITION  dual oxidase 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047288648
VERSION     XP_047288648.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432692.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1551
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1551
                     /product="dual oxidase 1 isoform X1"
                     /calculated_mol_wt=177105
     Region          32..591
                     /region_name="dual_peroxidase_like"
                     /note="Dual oxidase and related animal heme peroxidases;
                     cd09820"
                     /db_xref="CDD:188652"
     Site            order(241..242,324,327..329,331,334,367,419,422,426)
                     /site_type="other"
                     /note="putative heme binding site [chemical binding]"
                     /db_xref="CDD:188652"
     Site            order(292,295..296,300,323,327,329,493,497,501..502,
                     505..506,509)
                     /site_type="other"
                     /note="putative substrate binding site [chemical binding]"
                     /db_xref="CDD:188652"
     Region          820..881
                     /region_name="EFh"
                     /note="EF-hand, calcium binding motif; A diverse
                     superfamily of calcium sensors and calcium signal
                     modulators; most examples in this alignment model have 2
                     active canonical EF hands. Ca2+ binding induces a
                     conformational change in the EF-hand motif, leading to...;
                     cd00051"
                     /db_xref="CDD:238008"
     Site            order(828,830,832,839,864,866,868,875)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238008"
     Region          857..915
                     /region_name="EFh"
                     /note="EF-hand, calcium binding motif; A diverse
                     superfamily of calcium sensors and calcium signal
                     modulators; most examples in this alignment model have 2
                     active canonical EF hands. Ca2+ binding induces a
                     conformational change in the EF-hand motif, leading to...;
                     cd00051"
                     /db_xref="CDD:238008"
     Region          1089..>1412
                     /region_name="PLN02292"
                     /note="ferric-chelate reductase"
                     /db_xref="CDD:215165"
     Region          1277..1551
                     /region_name="NOX_Duox_like_FAD_NADP"
                     /note="NADPH oxidase (NOX) catalyzes the generation of
                     reactive oxygen species (ROS) such as superoxide and
                     hydrogen peroxide. ROS were originally identified as
                     bactericidal agents in phagocytes, but are now also
                     implicated in cell signaling and metabolism. NOX...;
                     cd06186"
                     /db_xref="CDD:99783"
     Site            order(1305,1319..1322,1335..1337,1340..1343,1390)
                     /site_type="other"
                     /note="FAD binding pocket [chemical binding]"
                     /db_xref="CDD:99783"
     Site            order(1319,1321..1322)
                     /site_type="other"
                     /note="FAD binding motif [chemical binding]"
                     /db_xref="CDD:99783"
     Site            1385..1395
                     /site_type="other"
                     /note="NAD pyrophosphate binding region [chemical
                     binding]"
                     /db_xref="CDD:99783"
     Site            order(1385,1389..1392,1394)
                     /site_type="other"
                     /note="beta-alpha-beta stucture motif"
                     /db_xref="CDD:99783"
     Site            order(1390..1391,1422..1424,1521..1522)
                     /site_type="other"
                     /note="NAD binding pocket [chemical binding]"
                     /db_xref="CDD:99783"
     Site            order(1420..1421,1424)
                     /site_type="other"
                     /note="NADP ribose binding motif [chemical binding]"
                     /db_xref="CDD:99783"
     CDS             1..1551
                     /gene="DUOX1"
                     /gene_synonym="LNOX1; NOXEF1; THOX1"
                     /coded_by="XM_047432692.1:1562..6217"
                     /db_xref="GeneID:53905"
                     /db_xref="HGNC:HGNC:3062"
                     /db_xref="MIM:606758"
ORIGIN      
        1 mgfclalawt llvgawtplg aqnpiswevq rfdgwynnlm ehrwgskgsr lqrlvpasya
       61 dgvyqplgep hlpnprdlsn tisrgpagla slrnrtvlgv ffgyhvlsdl vsvetpgcpa
      121 eflnirippg dpmfdpdqrg dvvlpfqrsr wdpetgrsps nprdpanqvt gwldgsaiyg
      181 sshswsdalr sfsrgqlasg pdpafprdsq npllmwaapd patgqngprg lyafgaergn
      241 repflqalgl lwfryhnlwa qrlarqhpdw edeelfqhar krviatyqni avyewlpsfl
      301 qktlpeytgy rpfldpsiss efvaaseqfl stmvppgvym rnaschfqgv inrnssvsra
      361 lrvcnsywsr ehpslqsaed vdalllgmas qiaeredhvl vedvrdfwpg plkfsrtdhl
      421 asclqrgrdl glpsytkara alglspitrw qdinpalsrs ndtvleataa lynqdlswle
      481 llpggllesh rdpgplfsti vleqfvrlrd gdrywfentr nglfskkeie eirnttlqdv
      541 lvavinidps alqpnvfvwh kgdpcpqprq lsteglpaca psvvrdyfeg sgfgfgvtig
      601 tlccfplvsl lsawivarlr mrnfkrlqgq drqsivsekl vggmealewq ghkepcrpvl
      661 vylqpgqirv vdgrltvlrt iqlqppqkvn fvlssnrgrr tlllkipkey dlvllfnlee
      721 erqalvenlr galkesglsi qewelreqel mraavtreqr rhlletffrh lfsqvldinq
      781 adagtlplds sqkvrealtc elsraefaes lglkpqdmfv esmfsladkd gngylsfref
      841 ldilvvfmkg speeksrlmf rmydfdgngl iskdefirml rsfieisnnc lskaqlaevv
      901 esmfresgfq dkeeltwedf hfmlrdhnse lrftqlcvkg vevpevikdl crrasyisqd
      961 micpsprvsa rcsrsdiete ltpqrlqcpm dtdppqeirr rfgkkvtsfq pllfteahre
     1021 kfqrsclhqt vqqfkrfien yrrhigcvav fyaiagglfl erayyyafaa hhtgitdttr
     1081 vgiilsrgta asisfmfsyi lltmcrnlit flretflnry vpfdaavdfh rliastaivl
     1141 tvlhsvghvv nvylfsispl svlsclfpgl fhddgselpq kyywwffqtv pgltgvvlll
     1201 ilaimyvfas hhfrrrsfrg fwlthhlyil lyvlliihgs faliqlprfh ifflvpaiiy
     1261 ggdklvslsr kkveisvvka ellpsgvthl rfqrpqgfey ksgqwvriac lalgtteyhp
     1321 ftltsaphed tlslhiraag pwttrlreiy saptgdrcar ypklyldgpf geghqewhkf
     1381 evsvlvgggi gvtpfasilk dlvfkssvsc qvfckkiyfi wvtrtqrqfe wladiireve
     1441 endhqdlvsv hiyitqlaek fdlrttmlyi cerhfqkvln rslftglrsi thfgrppfep
     1501 ffnslqevhp qvrkigvfsc gppgmtknve kacqlinrqd rthfshhyen f
//
LOCUS       XP_047288649            1551 aa            linear   PRI 05-AUG-2025
DEFINITION  dual oxidase 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047288649
VERSION     XP_047288649.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432693.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1551
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1551
                     /product="dual oxidase 1 isoform X1"
                     /calculated_mol_wt=177105
     Region          32..591
                     /region_name="dual_peroxidase_like"
                     /note="Dual oxidase and related animal heme peroxidases;
                     cd09820"
                     /db_xref="CDD:188652"
     Site            order(241..242,324,327..329,331,334,367,419,422,426)
                     /site_type="other"
                     /note="putative heme binding site [chemical binding]"
                     /db_xref="CDD:188652"
     Site            order(292,295..296,300,323,327,329,493,497,501..502,
                     505..506,509)
                     /site_type="other"
                     /note="putative substrate binding site [chemical binding]"
                     /db_xref="CDD:188652"
     Region          820..881
                     /region_name="EFh"
                     /note="EF-hand, calcium binding motif; A diverse
                     superfamily of calcium sensors and calcium signal
                     modulators; most examples in this alignment model have 2
                     active canonical EF hands. Ca2+ binding induces a
                     conformational change in the EF-hand motif, leading to...;
                     cd00051"
                     /db_xref="CDD:238008"
     Site            order(828,830,832,839,864,866,868,875)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238008"
     Region          857..915
                     /region_name="EFh"
                     /note="EF-hand, calcium binding motif; A diverse
                     superfamily of calcium sensors and calcium signal
                     modulators; most examples in this alignment model have 2
                     active canonical EF hands. Ca2+ binding induces a
                     conformational change in the EF-hand motif, leading to...;
                     cd00051"
                     /db_xref="CDD:238008"
     Region          1089..>1412
                     /region_name="PLN02292"
                     /note="ferric-chelate reductase"
                     /db_xref="CDD:215165"
     Region          1277..1551
                     /region_name="NOX_Duox_like_FAD_NADP"
                     /note="NADPH oxidase (NOX) catalyzes the generation of
                     reactive oxygen species (ROS) such as superoxide and
                     hydrogen peroxide. ROS were originally identified as
                     bactericidal agents in phagocytes, but are now also
                     implicated in cell signaling and metabolism. NOX...;
                     cd06186"
                     /db_xref="CDD:99783"
     Site            order(1305,1319..1322,1335..1337,1340..1343,1390)
                     /site_type="other"
                     /note="FAD binding pocket [chemical binding]"
                     /db_xref="CDD:99783"
     Site            order(1319,1321..1322)
                     /site_type="other"
                     /note="FAD binding motif [chemical binding]"
                     /db_xref="CDD:99783"
     Site            1385..1395
                     /site_type="other"
                     /note="NAD pyrophosphate binding region [chemical
                     binding]"
                     /db_xref="CDD:99783"
     Site            order(1385,1389..1392,1394)
                     /site_type="other"
                     /note="beta-alpha-beta stucture motif"
                     /db_xref="CDD:99783"
     Site            order(1390..1391,1422..1424,1521..1522)
                     /site_type="other"
                     /note="NAD binding pocket [chemical binding]"
                     /db_xref="CDD:99783"
     Site            order(1420..1421,1424)
                     /site_type="other"
                     /note="NADP ribose binding motif [chemical binding]"
                     /db_xref="CDD:99783"
     CDS             1..1551
                     /gene="DUOX1"
                     /gene_synonym="LNOX1; NOXEF1; THOX1"
                     /coded_by="XM_047432693.1:1577..6232"
                     /db_xref="GeneID:53905"
                     /db_xref="HGNC:HGNC:3062"
                     /db_xref="MIM:606758"
ORIGIN      
        1 mgfclalawt llvgawtplg aqnpiswevq rfdgwynnlm ehrwgskgsr lqrlvpasya
       61 dgvyqplgep hlpnprdlsn tisrgpagla slrnrtvlgv ffgyhvlsdl vsvetpgcpa
      121 eflnirippg dpmfdpdqrg dvvlpfqrsr wdpetgrsps nprdpanqvt gwldgsaiyg
      181 sshswsdalr sfsrgqlasg pdpafprdsq npllmwaapd patgqngprg lyafgaergn
      241 repflqalgl lwfryhnlwa qrlarqhpdw edeelfqhar krviatyqni avyewlpsfl
      301 qktlpeytgy rpfldpsiss efvaaseqfl stmvppgvym rnaschfqgv inrnssvsra
      361 lrvcnsywsr ehpslqsaed vdalllgmas qiaeredhvl vedvrdfwpg plkfsrtdhl
      421 asclqrgrdl glpsytkara alglspitrw qdinpalsrs ndtvleataa lynqdlswle
      481 llpggllesh rdpgplfsti vleqfvrlrd gdrywfentr nglfskkeie eirnttlqdv
      541 lvavinidps alqpnvfvwh kgdpcpqprq lsteglpaca psvvrdyfeg sgfgfgvtig
      601 tlccfplvsl lsawivarlr mrnfkrlqgq drqsivsekl vggmealewq ghkepcrpvl
      661 vylqpgqirv vdgrltvlrt iqlqppqkvn fvlssnrgrr tlllkipkey dlvllfnlee
      721 erqalvenlr galkesglsi qewelreqel mraavtreqr rhlletffrh lfsqvldinq
      781 adagtlplds sqkvrealtc elsraefaes lglkpqdmfv esmfsladkd gngylsfref
      841 ldilvvfmkg speeksrlmf rmydfdgngl iskdefirml rsfieisnnc lskaqlaevv
      901 esmfresgfq dkeeltwedf hfmlrdhnse lrftqlcvkg vevpevikdl crrasyisqd
      961 micpsprvsa rcsrsdiete ltpqrlqcpm dtdppqeirr rfgkkvtsfq pllfteahre
     1021 kfqrsclhqt vqqfkrfien yrrhigcvav fyaiagglfl erayyyafaa hhtgitdttr
     1081 vgiilsrgta asisfmfsyi lltmcrnlit flretflnry vpfdaavdfh rliastaivl
     1141 tvlhsvghvv nvylfsispl svlsclfpgl fhddgselpq kyywwffqtv pgltgvvlll
     1201 ilaimyvfas hhfrrrsfrg fwlthhlyil lyvlliihgs faliqlprfh ifflvpaiiy
     1261 ggdklvslsr kkveisvvka ellpsgvthl rfqrpqgfey ksgqwvriac lalgtteyhp
     1321 ftltsaphed tlslhiraag pwttrlreiy saptgdrcar ypklyldgpf geghqewhkf
     1381 evsvlvgggi gvtpfasilk dlvfkssvsc qvfckkiyfi wvtrtqrqfe wladiireve
     1441 endhqdlvsv hiyitqlaek fdlrttmlyi cerhfqkvln rslftglrsi thfgrppfep
     1501 ffnslqevhp qvrkigvfsc gppgmtknve kacqlinrqd rthfshhyen f
//
LOCUS       XP_011519983            1512 aa            linear   PRI 05-AUG-2025
DEFINITION  dual oxidase 1 isoform X2 [Homo sapiens].
ACCESSION   XP_011519983
VERSION     XP_011519983.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521681.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1512
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1512
                     /product="dual oxidase 1 isoform X2"
                     /calculated_mol_wt=172683
     Region          3..552
                     /region_name="dual_peroxidase_like"
                     /note="Dual oxidase and related animal heme peroxidases;
                     cd09820"
                     /db_xref="CDD:188652"
     Site            order(202..203,285,288..290,292,295,328,380,383,387)
                     /site_type="other"
                     /note="putative heme binding site [chemical binding]"
                     /db_xref="CDD:188652"
     Site            order(253,256..257,261,284,288,290,454,458,462..463,
                     466..467,470)
                     /site_type="other"
                     /note="putative substrate binding site [chemical binding]"
                     /db_xref="CDD:188652"
     Region          781..842
                     /region_name="EFh"
                     /note="EF-hand, calcium binding motif; A diverse
                     superfamily of calcium sensors and calcium signal
                     modulators; most examples in this alignment model have 2
                     active canonical EF hands. Ca2+ binding induces a
                     conformational change in the EF-hand motif, leading to...;
                     cd00051"
                     /db_xref="CDD:238008"
     Site            order(789,791,793,800,825,827,829,836)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238008"
     Region          818..876
                     /region_name="EFh"
                     /note="EF-hand, calcium binding motif; A diverse
                     superfamily of calcium sensors and calcium signal
                     modulators; most examples in this alignment model have 2
                     active canonical EF hands. Ca2+ binding induces a
                     conformational change in the EF-hand motif, leading to...;
                     cd00051"
                     /db_xref="CDD:238008"
     Region          1050..>1373
                     /region_name="PLN02292"
                     /note="ferric-chelate reductase"
                     /db_xref="CDD:215165"
     Region          1238..1512
                     /region_name="NOX_Duox_like_FAD_NADP"
                     /note="NADPH oxidase (NOX) catalyzes the generation of
                     reactive oxygen species (ROS) such as superoxide and
                     hydrogen peroxide. ROS were originally identified as
                     bactericidal agents in phagocytes, but are now also
                     implicated in cell signaling and metabolism. NOX...;
                     cd06186"
                     /db_xref="CDD:99783"
     Site            order(1266,1280..1283,1296..1298,1301..1304,1351)
                     /site_type="other"
                     /note="FAD binding pocket [chemical binding]"
                     /db_xref="CDD:99783"
     Site            order(1280,1282..1283)
                     /site_type="other"
                     /note="FAD binding motif [chemical binding]"
                     /db_xref="CDD:99783"
     Site            1346..1356
                     /site_type="other"
                     /note="NAD pyrophosphate binding region [chemical
                     binding]"
                     /db_xref="CDD:99783"
     Site            order(1346,1350..1353,1355)
                     /site_type="other"
                     /note="beta-alpha-beta stucture motif"
                     /db_xref="CDD:99783"
     Site            order(1351..1352,1383..1385,1482..1483)
                     /site_type="other"
                     /note="NAD binding pocket [chemical binding]"
                     /db_xref="CDD:99783"
     Site            order(1381..1382,1385)
                     /site_type="other"
                     /note="NADP ribose binding motif [chemical binding]"
                     /db_xref="CDD:99783"
     CDS             1..1512
                     /gene="DUOX1"
                     /gene_synonym="LNOX1; NOXEF1; THOX1"
                     /coded_by="XM_011521681.3:165..4703"
                     /db_xref="GeneID:53905"
                     /db_xref="HGNC:HGNC:3062"
                     /db_xref="MIM:606758"
ORIGIN      
        1 mehrwgskgs rlqrlvpasy adgvyqplge phlpnprdls ntisrgpagl aslrnrtvlg
       61 vffgyhvlsd lvsvetpgcp aeflniripp gdpmfdpdqr gdvvlpfqrs rwdpetgrsp
      121 snprdpanqv tgwldgsaiy gsshswsdal rsfsrgqlas gpdpafprds qnpllmwaap
      181 dpatgqngpr glyafgaerg nrepflqalg llwfryhnlw aqrlarqhpd wedeelfqha
      241 rkrviatyqn iavyewlpsf lqktlpeytg yrpfldpsis sefvaaseqf lstmvppgvy
      301 mrnaschfqg vinrnssvsr alrvcnsyws rehpslqsae dvdalllgma sqiaeredhv
      361 lvedvrdfwp gplkfsrtdh lasclqrgrd lglpsytkar aalglspitr wqdinpalsr
      421 sndtvleata alynqdlswl ellpgglles hrdpgplfst ivleqfvrlr dgdrywfent
      481 rnglfskkei eeirnttlqd vlvavinidp salqpnvfvw hkgdpcpqpr qlsteglpac
      541 apsvvrdyfe gsgfgfgvti gtlccfplvs llsawivarl rmrnfkrlqg qdrqsivsek
      601 lvggmealew qghkepcrpv lvylqpgqir vvdgrltvlr tiqlqppqkv nfvlssnrgr
      661 rtlllkipke ydlvllfnle eerqalvenl rgalkesgls iqewelreqe lmraavtreq
      721 rrhlletffr hlfsqvldin qadagtlpld ssqkvrealt celsraefae slglkpqdmf
      781 vesmfsladk dgngylsfre fldilvvfmk gspeeksrlm frmydfdgng liskdefirm
      841 lrsfieisnn clskaqlaev vesmfresgf qdkeeltwed fhfmlrdhns elrftqlcvk
      901 gvevpevikd lcrrasyisq dmicpsprvs arcsrsdiet eltpqrlqcp mdtdppqeir
      961 rrfgkkvtsf qpllfteahr ekfqrsclhq tvqqfkrfie nyrrhigcva vfyaiagglf
     1021 lerayyyafa ahhtgitdtt rvgiilsrgt aasisfmfsy illtmcrnli tflretflnr
     1081 yvpfdaavdf hrliastaiv ltvlhsvghv vnvylfsisp lsvlsclfpg lfhddgselp
     1141 qkyywwffqt vpgltgvvll lilaimyvfa shhfrrrsfr gfwlthhlyi llyvlliihg
     1201 sfaliqlprf hifflvpaii yggdklvsls rkkveisvvk aellpsgvth lrfqrpqgfe
     1261 yksgqwvria clalgtteyh pftltsaphe dtlslhiraa gpwttrlrei ysaptgdrca
     1321 rypklyldgp fgeghqewhk fevsvlvggg igvtpfasil kdlvfkssvs cqvfckkiyf
     1381 iwvtrtqrqf ewladiirev eendhqdlvs vhiyitqlae kfdlrttmly icerhfqkvl
     1441 nrslftglrs ithfgrppfe pffnslqevh pqvrkigvfs cgppgmtknv ekacqlinrq
     1501 drthfshhye nf
//
LOCUS       XP_011519984            1197 aa            linear   PRI 05-AUG-2025
DEFINITION  dual oxidase 1 isoform X3 [Homo sapiens].
ACCESSION   XP_011519984
VERSION     XP_011519984.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521682.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1197
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1197
                     /product="dual oxidase 1 isoform X3"
                     /calculated_mol_wt=137474
     Region          <52..237
                     /region_name="An_peroxidase_like"
                     /note="Animal heme peroxidases and related proteins;
                     cl14561"
                     /db_xref="CDD:353811"
     Region          466..527
                     /region_name="EFh"
                     /note="EF-hand, calcium binding motif; A diverse
                     superfamily of calcium sensors and calcium signal
                     modulators; most examples in this alignment model have 2
                     active canonical EF hands. Ca2+ binding induces a
                     conformational change in the EF-hand motif, leading to...;
                     cd00051"
                     /db_xref="CDD:238008"
     Site            order(474,476,478,485,510,512,514,521)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238008"
     Region          503..561
                     /region_name="EFh"
                     /note="EF-hand, calcium binding motif; A diverse
                     superfamily of calcium sensors and calcium signal
                     modulators; most examples in this alignment model have 2
                     active canonical EF hands. Ca2+ binding induces a
                     conformational change in the EF-hand motif, leading to...;
                     cd00051"
                     /db_xref="CDD:238008"
     Region          735..>1058
                     /region_name="PLN02292"
                     /note="ferric-chelate reductase"
                     /db_xref="CDD:215165"
     Region          923..1197
                     /region_name="NOX_Duox_like_FAD_NADP"
                     /note="NADPH oxidase (NOX) catalyzes the generation of
                     reactive oxygen species (ROS) such as superoxide and
                     hydrogen peroxide. ROS were originally identified as
                     bactericidal agents in phagocytes, but are now also
                     implicated in cell signaling and metabolism. NOX...;
                     cd06186"
                     /db_xref="CDD:99783"
     Site            order(951,965..968,981..983,986..989,1036)
                     /site_type="other"
                     /note="FAD binding pocket [chemical binding]"
                     /db_xref="CDD:99783"
     Site            order(965,967..968)
                     /site_type="other"
                     /note="FAD binding motif [chemical binding]"
                     /db_xref="CDD:99783"
     Site            1031..1041
                     /site_type="other"
                     /note="NAD pyrophosphate binding region [chemical
                     binding]"
                     /db_xref="CDD:99783"
     Site            order(1031,1035..1038,1040)
                     /site_type="other"
                     /note="beta-alpha-beta stucture motif"
                     /db_xref="CDD:99783"
     Site            order(1036..1037,1068..1070,1167..1168)
                     /site_type="other"
                     /note="NAD binding pocket [chemical binding]"
                     /db_xref="CDD:99783"
     Site            order(1066..1067,1070)
                     /site_type="other"
                     /note="NADP ribose binding motif [chemical binding]"
                     /db_xref="CDD:99783"
     CDS             1..1197
                     /gene="DUOX1"
                     /gene_synonym="LNOX1; NOXEF1; THOX1"
                     /coded_by="XM_011521682.2:20..3613"
                     /db_xref="GeneID:53905"
                     /db_xref="HGNC:HGNC:3062"
                     /db_xref="MIM:606758"
ORIGIN      
        1 mwmhccwawp prsqsertmc wlkmcgvslr lslqvvnswp lgrgsaglpe pdfwpgplkf
       61 srtdhlascl qrgrdlglps ytkaraalgl spitrwqdin palsrsndtv leataalynq
      121 dlswlellpg glleshrdpg plfstivleq fvrlrdgdry wfentrnglf skkeieeirn
      181 ttlqdvlvav inidpsalqp nvfvwhkgdp cpqprqlste glpacapsvv rdyfegsgfg
      241 fgvtigtlcc fplvsllsaw ivarlrmrnf krlqgqdrqs ivseklvggm ealewqghke
      301 pcrpvlvylq pgqirvvdgr ltvlrtiqlq ppqkvnfvls snrgrrtlll kipkeydlvl
      361 lfnleeerqa lvenlrgalk esglsiqewe lreqelmraa vtreqrrhll etffrhlfsq
      421 vldinqadag tlpldssqkv realtcelsr aefaeslglk pqdmfvesmf sladkdgngy
      481 lsfrefldil vvfmkgspee ksrlmfrmyd fdgngliskd efirmlrsfi eisnnclska
      541 qlaevvesmf resgfqdkee ltwedfhfml rdhnselrft qlcvkgvevp evikdlcrra
      601 syisqdmicp sprvsarcsr sdieteltpq rlqcpmdtdp pqeirrrfgk kvtsfqpllf
      661 teahrekfqr sclhqtvqqf krfienyrrh igcvavfyai agglfleray yyafaahhtg
      721 itdttrvgii lsrgtaasis fmfsyilltm crnlitflre tflnryvpfd aavdfhrlia
      781 staivltvlh svghvvnvyl fsisplsvls clfpglfhdd gselpqkyyw wffqtvpglt
      841 gvvlllilai myvfashhfr rrsfrgfwlt hhlyillyvl liihgsfali qlprfhiffl
      901 vpaiiyggdk lvslsrkkve isvvkaellp sgvthlrfqr pqgfeyksgq wvriaclalg
      961 tteyhpftlt saphedtlsl hiraagpwtt rlreiysapt gdrcarypkl yldgpfgegh
     1021 qewhkfevsv lvgggigvtp fasilkdlvf kssvscqvfc kkiyfiwvtr tqrqfewlad
     1081 iireveendh qdlvsvhiyi tqlaekfdlr ttmlyicerh fqkvlnrslf tglrsithfg
     1141 rppfepffns lqevhpqvrk igvfscgppg mtknvekacq linrqdrthf shhyenf
//
LOCUS       XP_047288650             208 aa            linear   PRI 05-AUG-2025
DEFINITION  AN1-type zinc finger protein 6 isoform X1 [Homo sapiens].
ACCESSION   XP_047288650
VERSION     XP_047288650.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432694.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..208
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..208
                     /product="AN1-type zinc finger protein 6 isoform X1"
                     /calculated_mol_wt=22424
     Region          12..35
                     /region_name="zf-A20"
                     /note="A20-like zinc finger; pfam01754"
                     /db_xref="CDD:460313"
     Region          149..186
                     /region_name="ZnF_AN1"
                     /note="AN1-like Zinc finger; smart00154"
                     /db_xref="CDD:197545"
     CDS             1..208
                     /gene="ZFAND6"
                     /gene_synonym="AWP1; ZA20D3; ZFAND5B"
                     /coded_by="XM_047432694.1:40..666"
                     /db_xref="GeneID:54469"
                     /db_xref="HGNC:HGNC:30164"
                     /db_xref="MIM:610183"
ORIGIN      
        1 maqetnhsqv pmlcstgcgf ygnprtngmc svcykehlqr qnssngrisp patsvsslse
       61 slpvqctdgs vpeaqsalds tsssmqpspv snqsllsesv assqldstsv dkavpetedv
      121 qasvsdtaqq pseeqsksle kpkqkknrcf mcrkkvgltg fecrcgnvyc gvhrysdvhn
      181 csynykadaa ekirkenpvv vgekiqki
//
LOCUS       XP_024305731             208 aa            linear   PRI 05-AUG-2025
DEFINITION  AN1-type zinc finger protein 6 isoform X1 [Homo sapiens].
ACCESSION   XP_024305731
VERSION     XP_024305731.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449963.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..208
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..208
                     /product="AN1-type zinc finger protein 6 isoform X1"
                     /calculated_mol_wt=22424
     Region          12..35
                     /region_name="zf-A20"
                     /note="A20-like zinc finger; pfam01754"
                     /db_xref="CDD:460313"
     Region          149..186
                     /region_name="ZnF_AN1"
                     /note="AN1-like Zinc finger; smart00154"
                     /db_xref="CDD:197545"
     CDS             1..208
                     /gene="ZFAND6"
                     /gene_synonym="AWP1; ZA20D3; ZFAND5B"
                     /coded_by="XM_024449963.2:60..686"
                     /db_xref="GeneID:54469"
                     /db_xref="HGNC:HGNC:30164"
                     /db_xref="MIM:610183"
ORIGIN      
        1 maqetnhsqv pmlcstgcgf ygnprtngmc svcykehlqr qnssngrisp patsvsslse
       61 slpvqctdgs vpeaqsalds tsssmqpspv snqsllsesv assqldstsv dkavpetedv
      121 qasvsdtaqq pseeqsksle kpkqkknrcf mcrkkvgltg fecrcgnvyc gvhrysdvhn
      181 csynykadaa ekirkenpvv vgekiqki
//
LOCUS       XP_011519986             208 aa            linear   PRI 05-AUG-2025
DEFINITION  AN1-type zinc finger protein 6 isoform X1 [Homo sapiens].
ACCESSION   XP_011519986
VERSION     XP_011519986.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521684.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..208
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..208
                     /product="AN1-type zinc finger protein 6 isoform X1"
                     /calculated_mol_wt=22424
     Region          12..35
                     /region_name="zf-A20"
                     /note="A20-like zinc finger; pfam01754"
                     /db_xref="CDD:460313"
     Region          149..186
                     /region_name="ZnF_AN1"
                     /note="AN1-like Zinc finger; smart00154"
                     /db_xref="CDD:197545"
     CDS             1..208
                     /gene="ZFAND6"
                     /gene_synonym="AWP1; ZA20D3; ZFAND5B"
                     /coded_by="XM_011521684.3:332..958"
                     /db_xref="GeneID:54469"
                     /db_xref="HGNC:HGNC:30164"
                     /db_xref="MIM:610183"
ORIGIN      
        1 maqetnhsqv pmlcstgcgf ygnprtngmc svcykehlqr qnssngrisp patsvsslse
       61 slpvqctdgs vpeaqsalds tsssmqpspv snqsllsesv assqldstsv dkavpetedv
      121 qasvsdtaqq pseeqsksle kpkqkknrcf mcrkkvgltg fecrcgnvyc gvhrysdvhn
      181 csynykadaa ekirkenpvv vgekiqki
//
LOCUS       XP_024305724             208 aa            linear   PRI 05-AUG-2025
DEFINITION  AN1-type zinc finger protein 6 isoform X1 [Homo sapiens].
ACCESSION   XP_024305724
VERSION     XP_024305724.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449956.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..208
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..208
                     /product="AN1-type zinc finger protein 6 isoform X1"
                     /calculated_mol_wt=22424
     Region          12..35
                     /region_name="zf-A20"
                     /note="A20-like zinc finger; pfam01754"
                     /db_xref="CDD:460313"
     Region          149..186
                     /region_name="ZnF_AN1"
                     /note="AN1-like Zinc finger; smart00154"
                     /db_xref="CDD:197545"
     CDS             1..208
                     /gene="ZFAND6"
                     /gene_synonym="AWP1; ZA20D3; ZFAND5B"
                     /coded_by="XM_024449956.2:223..849"
                     /db_xref="GeneID:54469"
                     /db_xref="HGNC:HGNC:30164"
                     /db_xref="MIM:610183"
ORIGIN      
        1 maqetnhsqv pmlcstgcgf ygnprtngmc svcykehlqr qnssngrisp patsvsslse
       61 slpvqctdgs vpeaqsalds tsssmqpspv snqsllsesv assqldstsv dkavpetedv
      121 qasvsdtaqq pseeqsksle kpkqkknrcf mcrkkvgltg fecrcgnvyc gvhrysdvhn
      181 csynykadaa ekirkenpvv vgekiqki
//
LOCUS       XP_047288651             208 aa            linear   PRI 05-AUG-2025
DEFINITION  AN1-type zinc finger protein 6 isoform X1 [Homo sapiens].
ACCESSION   XP_047288651
VERSION     XP_047288651.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432695.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..208
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..208
                     /product="AN1-type zinc finger protein 6 isoform X1"
                     /calculated_mol_wt=22424
     Region          12..35
                     /region_name="zf-A20"
                     /note="A20-like zinc finger; pfam01754"
                     /db_xref="CDD:460313"
     Region          149..186
                     /region_name="ZnF_AN1"
                     /note="AN1-like Zinc finger; smart00154"
                     /db_xref="CDD:197545"
     CDS             1..208
                     /gene="ZFAND6"
                     /gene_synonym="AWP1; ZA20D3; ZFAND5B"
                     /coded_by="XM_047432695.1:411..1037"
                     /db_xref="GeneID:54469"
                     /db_xref="HGNC:HGNC:30164"
                     /db_xref="MIM:610183"
ORIGIN      
        1 maqetnhsqv pmlcstgcgf ygnprtngmc svcykehlqr qnssngrisp patsvsslse
       61 slpvqctdgs vpeaqsalds tsssmqpspv snqsllsesv assqldstsv dkavpetedv
      121 qasvsdtaqq pseeqsksle kpkqkknrcf mcrkkvgltg fecrcgnvyc gvhrysdvhn
      181 csynykadaa ekirkenpvv vgekiqki
//
LOCUS       XP_024305727             208 aa            linear   PRI 05-AUG-2025
DEFINITION  AN1-type zinc finger protein 6 isoform X1 [Homo sapiens].
ACCESSION   XP_024305727
VERSION     XP_024305727.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449959.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..208
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..208
                     /product="AN1-type zinc finger protein 6 isoform X1"
                     /calculated_mol_wt=22424
     Region          12..35
                     /region_name="zf-A20"
                     /note="A20-like zinc finger; pfam01754"
                     /db_xref="CDD:460313"
     Region          149..186
                     /region_name="ZnF_AN1"
                     /note="AN1-like Zinc finger; smart00154"
                     /db_xref="CDD:197545"
     CDS             1..208
                     /gene="ZFAND6"
                     /gene_synonym="AWP1; ZA20D3; ZFAND5B"
                     /coded_by="XM_024449959.2:288..914"
                     /db_xref="GeneID:54469"
                     /db_xref="HGNC:HGNC:30164"
                     /db_xref="MIM:610183"
ORIGIN      
        1 maqetnhsqv pmlcstgcgf ygnprtngmc svcykehlqr qnssngrisp patsvsslse
       61 slpvqctdgs vpeaqsalds tsssmqpspv snqsllsesv assqldstsv dkavpetedv
      121 qasvsdtaqq pseeqsksle kpkqkknrcf mcrkkvgltg fecrcgnvyc gvhrysdvhn
      181 csynykadaa ekirkenpvv vgekiqki
//
LOCUS       XP_047288652             208 aa            linear   PRI 05-AUG-2025
DEFINITION  AN1-type zinc finger protein 6 isoform X1 [Homo sapiens].
ACCESSION   XP_047288652
VERSION     XP_047288652.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432696.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..208
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..208
                     /product="AN1-type zinc finger protein 6 isoform X1"
                     /calculated_mol_wt=22424
     Region          12..35
                     /region_name="zf-A20"
                     /note="A20-like zinc finger; pfam01754"
                     /db_xref="CDD:460313"
     Region          149..186
                     /region_name="ZnF_AN1"
                     /note="AN1-like Zinc finger; smart00154"
                     /db_xref="CDD:197545"
     CDS             1..208
                     /gene="ZFAND6"
                     /gene_synonym="AWP1; ZA20D3; ZFAND5B"
                     /coded_by="XM_047432696.1:375..1001"
                     /db_xref="GeneID:54469"
                     /db_xref="HGNC:HGNC:30164"
                     /db_xref="MIM:610183"
ORIGIN      
        1 maqetnhsqv pmlcstgcgf ygnprtngmc svcykehlqr qnssngrisp patsvsslse
       61 slpvqctdgs vpeaqsalds tsssmqpspv snqsllsesv assqldstsv dkavpetedv
      121 qasvsdtaqq pseeqsksle kpkqkknrcf mcrkkvgltg fecrcgnvyc gvhrysdvhn
      181 csynykadaa ekirkenpvv vgekiqki
//
LOCUS       XP_047288653             208 aa            linear   PRI 05-AUG-2025
DEFINITION  AN1-type zinc finger protein 6 isoform X1 [Homo sapiens].
ACCESSION   XP_047288653
VERSION     XP_047288653.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432697.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..208
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..208
                     /product="AN1-type zinc finger protein 6 isoform X1"
                     /calculated_mol_wt=22424
     Region          12..35
                     /region_name="zf-A20"
                     /note="A20-like zinc finger; pfam01754"
                     /db_xref="CDD:460313"
     Region          149..186
                     /region_name="ZnF_AN1"
                     /note="AN1-like Zinc finger; smart00154"
                     /db_xref="CDD:197545"
     CDS             1..208
                     /gene="ZFAND6"
                     /gene_synonym="AWP1; ZA20D3; ZFAND5B"
                     /coded_by="XM_047432697.1:216..842"
                     /db_xref="GeneID:54469"
                     /db_xref="HGNC:HGNC:30164"
                     /db_xref="MIM:610183"
ORIGIN      
        1 maqetnhsqv pmlcstgcgf ygnprtngmc svcykehlqr qnssngrisp patsvsslse
       61 slpvqctdgs vpeaqsalds tsssmqpspv snqsllsesv assqldstsv dkavpetedv
      121 qasvsdtaqq pseeqsksle kpkqkknrcf mcrkkvgltg fecrcgnvyc gvhrysdvhn
      181 csynykadaa ekirkenpvv vgekiqki
//
LOCUS       XP_047288654            1556 aa            linear   PRI 05-AUG-2025
DEFINITION  chromatin-remodeling ATPase INO80 isoform X1 [Homo sapiens].
ACCESSION   XP_047288654
VERSION     XP_047288654.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432698.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1556
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1556
                     /product="chromatin-remodeling ATPase INO80 isoform X1"
                     /calculated_mol_wt=176623
     Region          298..>830
                     /region_name="HepA"
                     /note="Superfamily II DNA or RNA helicase, SNF2 family
                     [Transcription, Replication, recombination, and repair];
                     COG0553"
                     /db_xref="CDD:440319"
     Region          518..746
                     /region_name="DEXQc_INO80"
                     /note="DEAQ-box helicase domain of INO80; cd18002"
                     /db_xref="CDD:350760"
     Site            order(545..551,585,652..653)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:350760"
     Region          1090..1225
                     /region_name="SF2_C_SNF"
                     /note="C-terminal helicase domain of the SNF family
                     helicases; cd18793"
                     /db_xref="CDD:350180"
     Site            order(1126..1127,1135,1177,1198..1199)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:350180"
     Site            order(1183..1184,1186,1209,1212)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:350180"
     CDS             1..1556
                     /gene="INO80"
                     /gene_synonym="INO80A; INOC1"
                     /coded_by="XM_047432698.1:185..4855"
                     /db_xref="GeneID:54617"
                     /db_xref="HGNC:HGNC:26956"
                     /db_xref="MIM:610169"
ORIGIN      
        1 maselgardd ggctelakpl ylqyleralr ldhflrqtsa ifnrnissdd sedglddsnp
       61 llpqsgdpli qvkeeppnsl lgetsgagss gmlntyslng vlqseskcdk gnlynfsklk
      121 ksrkwlksil lsdesseads qsedddeeel nlsreelhnm lrlhkykklh qnkyskdkel
      181 qqyqyysagl lstydpfyeq qrhllgpkkk kfkeekklka klkkvkkkrr rdeelssees
      241 prrhhhqtkv fakfshdapp pgtkkkhlsi eqlnarrrkv wlsivkkelp kankqkasar
      301 nlfltnsrkl ahqcmkevrr aalqaqknck etlprarrlt kemllywkky ekvekehrkr
      361 aekealeqrk ldeemreakr qqrklnflit qtelyahfms rkrdmghdgi qeeilrkled
      421 sstqrqidig ggvvvnitqe dydsnhfkaq alknaenayh ihqartrsfd edakesraaa
      481 lraanksgtg fgesyslanp siragedipq ptifngklkg yqlkgmnwla nlyeqgingi
      541 lademglgkt vqsiallahl aereniwgpf liispastln nwhqeftrfv pkfkvlpywg
      601 nphdrkvirr fwsqktlytq dapfhvvits yqlvvqdvky fqrvkwqymv ldeaqalkss
      661 ssvrwkillq fqcrnrlllt gtpiqntmae lwallhfimp tlfdsheefn ewfskdiesh
      721 aenksaiden qlsrlhmilk pfmlrrikkd venelsdkie ilmycqltsr qkllyqalkn
      781 kisiedllqs smgstqqaqn ttsslmnlvm qfrkvcnhpe lferqetwsp fhislkpyhi
      841 skfiyrhgqi rvfnhsrdrw lrvlspfapd yiqrslfhrk gineescfsf lrfidispae
      901 manlmlqgll arwlalflsl kasyrlhqlr swgapegesh qrylrnkdfl lgvnfplsfp
      961 nlcscpllks lvfsshckav sgysdqvvhq rrsatsslrr clltelpsfl cvasprvtav
     1021 pldsycndrs aeyerrvlke ggslaakqcl lngapelaad wlnrrsqffp epagglwsir
     1081 pqngwsfiri pgkeslitds gklyaldvll trlksqghrv liysqmtrmi dlleeymvyr
     1141 khtymrldgs skiserrdmv adfqnrndif vfllstragg lginltaadt vifydsdwnp
     1201 tvdqqamdra hrlgqtkqvt vyrlickgti eerilqrake kseiqrmvis ggnfkpdtlk
     1261 pkevvsllld deelekklrl rqeekrqqee tnrvkerkrk rekyaekkkk edeldgkrrk
     1321 egvnlvipfv psadnsnlsa dgddsfisvd sampspfsei sisselhtgs ipldesssdm
     1381 lvivddpass apqsratnsp asitgsvsdt vngisiqemp aagrghsars rgrpkgsgst
     1441 akgagkgrsr kstagsaaam agakagaaaa saaayaaygy nvskgisass plqtslvrpa
     1501 gladfgpssa ssplssplsk gnnvpgnpkn lhmtsslapd slvrkqgkgt npsggr
//
LOCUS       XP_011519987            1209 aa            linear   PRI 05-AUG-2025
DEFINITION  chromatin-remodeling ATPase INO80 isoform X2 [Homo sapiens].
ACCESSION   XP_011519987
VERSION     XP_011519987.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521685.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1209
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1209
                     /product="chromatin-remodeling ATPase INO80 isoform X2"
                     /calculated_mol_wt=140247
     Region          298..>830
                     /region_name="HepA"
                     /note="Superfamily II DNA or RNA helicase, SNF2 family
                     [Transcription, Replication, recombination, and repair];
                     COG0553"
                     /db_xref="CDD:440319"
     Region          518..746
                     /region_name="DEXQc_INO80"
                     /note="DEAQ-box helicase domain of INO80; cd18002"
                     /db_xref="CDD:350760"
     Site            order(545..551,585,652..653)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:350760"
     Region          1090..>1171
                     /region_name="SF2_C_SNF"
                     /note="C-terminal helicase domain of the SNF family
                     helicases; cd18793"
                     /db_xref="CDD:350180"
     CDS             1..1209
                     /gene="INO80"
                     /gene_synonym="INO80A; INOC1"
                     /coded_by="XM_011521685.4:352..3981"
                     /db_xref="GeneID:54617"
                     /db_xref="HGNC:HGNC:26956"
                     /db_xref="MIM:610169"
ORIGIN      
        1 maselgardd ggctelakpl ylqyleralr ldhflrqtsa ifnrnissdd sedglddsnp
       61 llpqsgdpli qvkeeppnsl lgetsgagss gmlntyslng vlqseskcdk gnlynfsklk
      121 ksrkwlksil lsdesseads qsedddeeel nlsreelhnm lrlhkykklh qnkyskdkel
      181 qqyqyysagl lstydpfyeq qrhllgpkkk kfkeekklka klkkvkkkrr rdeelssees
      241 prrhhhqtkv fakfshdapp pgtkkkhlsi eqlnarrrkv wlsivkkelp kankqkasar
      301 nlfltnsrkl ahqcmkevrr aalqaqknck etlprarrlt kemllywkky ekvekehrkr
      361 aekealeqrk ldeemreakr qqrklnflit qtelyahfms rkrdmghdgi qeeilrkled
      421 sstqrqidig ggvvvnitqe dydsnhfkaq alknaenayh ihqartrsfd edakesraaa
      481 lraanksgtg fgesyslanp siragedipq ptifngklkg yqlkgmnwla nlyeqgingi
      541 lademglgkt vqsiallahl aereniwgpf liispastln nwhqeftrfv pkfkvlpywg
      601 nphdrkvirr fwsqktlytq dapfhvvits yqlvvqdvky fqrvkwqymv ldeaqalkss
      661 ssvrwkillq fqcrnrlllt gtpiqntmae lwallhfimp tlfdsheefn ewfskdiesh
      721 aenksaiden qlsrlhmilk pfmlrrikkd venelsdkie ilmycqltsr qkllyqalkn
      781 kisiedllqs smgstqqaqn ttsslmnlvm qfrkvcnhpe lferqetwsp fhislkpyhi
      841 skfiyrhgqi rvfnhsrdrw lrvlspfapd yiqrslfhrk gineescfsf lrfidispae
      901 manlmlqgll arwlalflsl kasyrlhqlr swgapegesh qrylrnkdfl lgvnfplsfp
      961 nlcscpllks lvfsshckav sgysdqvvhq rrsatsslrr clltelpsfl cvasprvtav
     1021 pldsycndrs aeyerrvlke ggslaakqcl lngapelaad wlnrrsqffp epagglwsir
     1081 pqngwsfiri pgkeslitds gklyaldvll trlksqghrv liysqmtrmi dlleeymvyr
     1141 khtymrldgs skiserrdmv adfqnrtsei vkesrcnsch fkkllnllii iqiyvsgrek
     1201 enipdslyv
//
LOCUS       XP_011519988             906 aa            linear   PRI 05-AUG-2025
DEFINITION  chromatin-remodeling ATPase INO80 isoform X3 [Homo sapiens].
ACCESSION   XP_011519988
VERSION     XP_011519988.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521686.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..906
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..906
                     /product="chromatin-remodeling ATPase INO80 isoform X3"
                     /calculated_mol_wt=101180
     Region          <9..96
                     /region_name="DEAD-like_helicase_N"
                     /note="N-terminal helicase domain of the DEAD-box helicase
                     superfamily; cl28899"
                     /db_xref="CDD:475120"
     Region          <16..>181
                     /region_name="PLN03142"
                     /note="Probable chromatin-remodeling complex ATPase chain;
                     Provisional"
                     /db_xref="CDD:215601"
     Region          440..575
                     /region_name="SF2_C_SNF"
                     /note="C-terminal helicase domain of the SNF family
                     helicases; cd18793"
                     /db_xref="CDD:350180"
     Site            order(476..477,485,527,548..549)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:350180"
     Site            order(533..534,536,559,562)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:350180"
     CDS             1..906
                     /gene="INO80"
                     /gene_synonym="INO80A; INOC1"
                     /coded_by="XM_011521686.4:115..2835"
                     /db_xref="GeneID:54617"
                     /db_xref="HGNC:HGNC:26956"
                     /db_xref="MIM:610169"
ORIGIN      
        1 miekssegsg vsvrwkillq fqcrnrlllt gtpiqntmae lwallhfimp tlfdsheefn
       61 ewfskdiesh aenksaiden qlsrlhmilk pfmlrrikkd venelsdkie ilmycqltsr
      121 qkllyqalkn kisiedllqs smgstqqaqn ttsslmnlvm qfrkvcnhpe lferqetwsp
      181 fhislkpyhi skfiyrhgqi rvfnhsrdrw lrvlspfapd yiqrslfhrk gineescfsf
      241 lrfidispae manlmlqgll arwlalflsl kasyrlhqlr swgapegesh qrylrnkdfl
      301 lgvnfplsfp nlcscpllks lvfsshckav sgysdqvvhq rrsatsslrr clltelpsfl
      361 cvasprvtav pldsycndrs aeyerrvlke ggslaakqcl lngapelaad wlnrrsqffp
      421 epagglwsir pqngwsfiri pgkeslitds gklyaldvll trlksqghrv liysqmtrmi
      481 dlleeymvyr khtymrldgs skiserrdmv adfqnrndif vfllstragg lginltaadt
      541 vifydsdwnp tvdqqamdra hrlgqtkqvt vyrlickgti eerilqrake kseiqrmvis
      601 ggnfkpdtlk pkevvsllld deelekklrl rqeekrqqee tnrvkerkrk rekyaekkkk
      661 edeldgkrrk egvnlvipfv psadnsnlsa dgddsfisvd sampspfsei sisselhtgs
      721 ipldesssdm lvivddpass apqsratnsp asitgsvsdt vngisiqemp aagrghsars
      781 rgrpkgsgst akgagkgrsr kstagsaaam agakagaaaa saaayaaygy nvskgisass
      841 plqtslvrpa gladfgpssa ssplssplsk gnnvpgnpkn lhmtsslapd slvrkqgkgt
      901 npsggr
//
LOCUS       XP_011519989             639 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin carboxyl-terminal hydrolase MINDY-2 isoform X1 [Homo
            sapiens].
ACCESSION   XP_011519989
VERSION     XP_011519989.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521687.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..639
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..639
                     /product="ubiquitin carboxyl-terminal hydrolase MINDY-2
                     isoform X1"
                     /calculated_mol_wt=69073
     Region          <19..>209
                     /region_name="PRK07003"
                     /note="DNA polymerase III subunit gamma/tau"
                     /db_xref="CDD:235906"
     Region          279..408
                     /region_name="MINDY_DUB"
                     /note="MINDY deubiquitinase; pfam04424"
                     /db_xref="CDD:461303"
     CDS             1..639
                     /gene="MINDY2"
                     /gene_synonym="FAM63B"
                     /coded_by="XM_011521687.3:95..2014"
                     /db_xref="GeneID:54629"
                     /db_xref="HGNC:HGNC:26954"
                     /db_xref="MIM:618408"
ORIGIN      
        1 messpeslqp lehgvaagpa sgtgssqegl qetrlaagdg pgvwaaetsg gnglgaaaar
       61 rslpdsaspa gspevpgpcs ssagldlkds glespaaaea plrgqykvta spetavagvg
      121 helgtagdag arpdlagtcq aeltaagsee pssagglsss csdpsppges psldslesfs
      181 nlhsfpssce fnseegaenr vpeeeegaav lpgavplcke eegeetaqvl aaskerfpgq
      241 svyhikwiqw keentpiitq nengpcplla ilnvlllawk vklppmmeii taeqlmeylg
      301 dymldakpke iseiqrlnye qihhccrfkk ssktlkgknn msdamailhk lqtgldvnvr
      361 ftgvrvfeyt pecivfdlld iplyhgwlvd pqiddivkav gncsynqlve kiisckqsdn
      421 selvsegfva eqflnntatq ltyhglcelt stvqegelcv ffrnnhfstm tkykgqlyll
      481 vtdqgfltee kvvweslhnv dgdgnfcdse fhlrppsdpe tvykgqqdqi dqdylmalsl
      541 qqeqqsqein weqipegisd lelakklqee edrrasqyyq eqeqaaaaaa aastqaqqgq
      601 paqaspssgr qsgnserkrk eprekdkeke keknscvil
//
LOCUS       XP_011519990             638 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin carboxyl-terminal hydrolase MINDY-2 isoform X2 [Homo
            sapiens].
ACCESSION   XP_011519990
VERSION     XP_011519990.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521688.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..638
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..638
                     /product="ubiquitin carboxyl-terminal hydrolase MINDY-2
                     isoform X2"
                     /calculated_mol_wt=68945
     Region          <19..>209
                     /region_name="PRK07003"
                     /note="DNA polymerase III subunit gamma/tau"
                     /db_xref="CDD:235906"
     Region          279..408
                     /region_name="MINDY_DUB"
                     /note="MINDY deubiquitinase; pfam04424"
                     /db_xref="CDD:461303"
     CDS             1..638
                     /gene="MINDY2"
                     /gene_synonym="FAM63B"
                     /coded_by="XM_011521688.3:95..2011"
                     /db_xref="GeneID:54629"
                     /db_xref="HGNC:HGNC:26954"
                     /db_xref="MIM:618408"
ORIGIN      
        1 messpeslqp lehgvaagpa sgtgssqegl qetrlaagdg pgvwaaetsg gnglgaaaar
       61 rslpdsaspa gspevpgpcs ssagldlkds glespaaaea plrgqykvta spetavagvg
      121 helgtagdag arpdlagtcq aeltaagsee pssagglsss csdpsppges psldslesfs
      181 nlhsfpssce fnseegaenr vpeeeegaav lpgavplcke eegeetaqvl aaskerfpgq
      241 svyhikwiqw keentpiitq nengpcplla ilnvlllawk vklppmmeii taeqlmeylg
      301 dymldakpke iseiqrlnye qihhccrfkk ssktlkgknn msdamailhk lqtgldvnvr
      361 ftgvrvfeyt pecivfdlld iplyhgwlvd pqiddivkav gncsynqlve kiisckqsdn
      421 selvsegfva eqflnntatq ltyhglcelt stvqegelcv ffrnnhfstm tkykgqlyll
      481 vtdqgfltee kvvweslhnv dgdgnfcdse fhlrppsdpe tvykgqqdqi dqdylmalsl
      541 qqeqqsqein weqipegisd lelakklqee edrrasqyyq eqeqaaaaaa aastqaqgqp
      601 aqaspssgrq sgnserkrke prekdkekek eknscvil
//
LOCUS       XP_011519991             605 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin carboxyl-terminal hydrolase MINDY-2 isoform X3 [Homo
            sapiens].
ACCESSION   XP_011519991
VERSION     XP_011519991.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521689.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..605
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..605
                     /product="ubiquitin carboxyl-terminal hydrolase MINDY-2
                     isoform X3"
                     /calculated_mol_wt=65052
     Region          <19..>209
                     /region_name="PRK07003"
                     /note="DNA polymerase III subunit gamma/tau"
                     /db_xref="CDD:235906"
     Region          279..374
                     /region_name="MINDY_DUB"
                     /note="MINDY deubiquitinase; pfam04424"
                     /db_xref="CDD:461303"
     CDS             1..605
                     /gene="MINDY2"
                     /gene_synonym="FAM63B"
                     /coded_by="XM_011521689.3:95..1912"
                     /db_xref="GeneID:54629"
                     /db_xref="HGNC:HGNC:26954"
                     /db_xref="MIM:618408"
ORIGIN      
        1 messpeslqp lehgvaagpa sgtgssqegl qetrlaagdg pgvwaaetsg gnglgaaaar
       61 rslpdsaspa gspevpgpcs ssagldlkds glespaaaea plrgqykvta spetavagvg
      121 helgtagdag arpdlagtcq aeltaagsee pssagglsss csdpsppges psldslesfs
      181 nlhsfpssce fnseegaenr vpeeeegaav lpgavplcke eegeetaqvl aaskerfpgq
      241 svyhikwiqw keentpiitq nengpcplla ilnvlllawk vklppmmeii taeqlmeylg
      301 dymldakpke iseiqrlnye qihhccrfkk ssktlkgknn msdamailhk lqtgldvnid
      361 divkavgncs ynqlvekiis ckqsdnselv segfvaeqfl nntatqltyh glceltstvq
      421 egelcvffrn nhfstmtkyk gqlyllvtdq gflteekvvw eslhnvdgdg nfcdsefhlr
      481 ppsdpetvyk gqqdqidqdy lmalslqqeq qsqeinweqi pegisdlela kklqeeedrr
      541 asqyyqeqeq aaaaaaaast qaqqgqpaqa spssgrqsgn serkrkepre kdkekekekn
      601 scvil
//
LOCUS       XP_047288655             604 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin carboxyl-terminal hydrolase MINDY-2 isoform X4 [Homo
            sapiens].
ACCESSION   XP_047288655
VERSION     XP_047288655.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432699.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..604
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..604
                     /product="ubiquitin carboxyl-terminal hydrolase MINDY-2
                     isoform X4"
                     /calculated_mol_wt=64924
     Region          <19..>209
                     /region_name="PRK07003"
                     /note="DNA polymerase III subunit gamma/tau"
                     /db_xref="CDD:235906"
     Region          279..374
                     /region_name="MINDY_DUB"
                     /note="MINDY deubiquitinase; pfam04424"
                     /db_xref="CDD:461303"
     CDS             1..604
                     /gene="MINDY2"
                     /gene_synonym="FAM63B"
                     /coded_by="XM_047432699.1:95..1909"
                     /db_xref="GeneID:54629"
                     /db_xref="HGNC:HGNC:26954"
                     /db_xref="MIM:618408"
ORIGIN      
        1 messpeslqp lehgvaagpa sgtgssqegl qetrlaagdg pgvwaaetsg gnglgaaaar
       61 rslpdsaspa gspevpgpcs ssagldlkds glespaaaea plrgqykvta spetavagvg
      121 helgtagdag arpdlagtcq aeltaagsee pssagglsss csdpsppges psldslesfs
      181 nlhsfpssce fnseegaenr vpeeeegaav lpgavplcke eegeetaqvl aaskerfpgq
      241 svyhikwiqw keentpiitq nengpcplla ilnvlllawk vklppmmeii taeqlmeylg
      301 dymldakpke iseiqrlnye qihhccrfkk ssktlkgknn msdamailhk lqtgldvnid
      361 divkavgncs ynqlvekiis ckqsdnselv segfvaeqfl nntatqltyh glceltstvq
      421 egelcvffrn nhfstmtkyk gqlyllvtdq gflteekvvw eslhnvdgdg nfcdsefhlr
      481 ppsdpetvyk gqqdqidqdy lmalslqqeq qsqeinweqi pegisdlela kklqeeedrr
      541 asqyyqeqeq aaaaaaaast qaqgqpaqas pssgrqsgns erkrkeprek dkekekekns
      601 cvil
//
LOCUS       XP_011519992             587 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin carboxyl-terminal hydrolase MINDY-2 isoform X5 [Homo
            sapiens].
ACCESSION   XP_011519992
VERSION     XP_011519992.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521690.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..587
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..587
                     /product="ubiquitin carboxyl-terminal hydrolase MINDY-2
                     isoform X5"
                     /calculated_mol_wt=62955
     Region          <19..>209
                     /region_name="PRK07003"
                     /note="DNA polymerase III subunit gamma/tau"
                     /db_xref="CDD:235906"
     Region          279..356
                     /region_name="MINDY_DUB"
                     /note="MINDY deubiquitinase; pfam04424"
                     /db_xref="CDD:461303"
     CDS             1..587
                     /gene="MINDY2"
                     /gene_synonym="FAM63B"
                     /coded_by="XM_011521690.3:95..1858"
                     /db_xref="GeneID:54629"
                     /db_xref="HGNC:HGNC:26954"
                     /db_xref="MIM:618408"
ORIGIN      
        1 messpeslqp lehgvaagpa sgtgssqegl qetrlaagdg pgvwaaetsg gnglgaaaar
       61 rslpdsaspa gspevpgpcs ssagldlkds glespaaaea plrgqykvta spetavagvg
      121 helgtagdag arpdlagtcq aeltaagsee pssagglsss csdpsppges psldslesfs
      181 nlhsfpssce fnseegaenr vpeeeegaav lpgavplcke eegeetaqvl aaskerfpgq
      241 svyhikwiqw keentpiitq nengpcplla ilnvlllawk vklppmmeii taeqlmeylg
      301 dymldakpke iseiqrlnye qnmsdamail hklqtgldvn iddivkavgn csynqlveki
      361 isckqsdnse lvsegfvaeq flnntatqlt yhglceltst vqegelcvff rnnhfstmtk
      421 ykgqlyllvt dqgflteekv vweslhnvdg dgnfcdsefh lrppsdpetv ykgqqdqidq
      481 dylmalslqq eqqsqeinwe qipegisdle lakklqeeed rrasqyyqeq eqaaaaaaaa
      541 stqaqqgqpa qaspssgrqs gnserkrkep rekdkekeke knscvil
//
LOCUS       XP_024305732             586 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin carboxyl-terminal hydrolase MINDY-2 isoform X6 [Homo
            sapiens].
ACCESSION   XP_024305732
VERSION     XP_024305732.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449964.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..586
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..586
                     /product="ubiquitin carboxyl-terminal hydrolase MINDY-2
                     isoform X6"
                     /calculated_mol_wt=62827
     Region          <19..>209
                     /region_name="PRK07003"
                     /note="DNA polymerase III subunit gamma/tau"
                     /db_xref="CDD:235906"
     Region          279..356
                     /region_name="MINDY_DUB"
                     /note="MINDY deubiquitinase; pfam04424"
                     /db_xref="CDD:461303"
     CDS             1..586
                     /gene="MINDY2"
                     /gene_synonym="FAM63B"
                     /coded_by="XM_024449964.2:95..1855"
                     /db_xref="GeneID:54629"
                     /db_xref="HGNC:HGNC:26954"
                     /db_xref="MIM:618408"
ORIGIN      
        1 messpeslqp lehgvaagpa sgtgssqegl qetrlaagdg pgvwaaetsg gnglgaaaar
       61 rslpdsaspa gspevpgpcs ssagldlkds glespaaaea plrgqykvta spetavagvg
      121 helgtagdag arpdlagtcq aeltaagsee pssagglsss csdpsppges psldslesfs
      181 nlhsfpssce fnseegaenr vpeeeegaav lpgavplcke eegeetaqvl aaskerfpgq
      241 svyhikwiqw keentpiitq nengpcplla ilnvlllawk vklppmmeii taeqlmeylg
      301 dymldakpke iseiqrlnye qnmsdamail hklqtgldvn iddivkavgn csynqlveki
      361 isckqsdnse lvsegfvaeq flnntatqlt yhglceltst vqegelcvff rnnhfstmtk
      421 ykgqlyllvt dqgflteekv vweslhnvdg dgnfcdsefh lrppsdpetv ykgqqdqidq
      481 dylmalslqq eqqsqeinwe qipegisdle lakklqeeed rrasqyyqeq eqaaaaaaaa
      541 stqaqgqpaq aspssgrqsg nserkrkepr ekdkekekek nscvil
//
LOCUS       XP_016877821             557 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin carboxyl-terminal hydrolase MINDY-2 isoform X7 [Homo
            sapiens].
ACCESSION   XP_016877821
VERSION     XP_016877821.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022332.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..557
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..557
                     /product="ubiquitin carboxyl-terminal hydrolase MINDY-2
                     isoform X7"
                     /calculated_mol_wt=59846
     Region          <19..>209
                     /region_name="PRK07003"
                     /note="DNA polymerase III subunit gamma/tau"
                     /db_xref="CDD:235906"
     Region          279..392
                     /region_name="MINDY_DUB"
                     /note="MINDY deubiquitinase; pfam04424"
                     /db_xref="CDD:461303"
     CDS             1..557
                     /gene="MINDY2"
                     /gene_synonym="FAM63B"
                     /coded_by="XM_017022332.3:95..1768"
                     /db_xref="GeneID:54629"
                     /db_xref="HGNC:HGNC:26954"
                     /db_xref="MIM:618408"
ORIGIN      
        1 messpeslqp lehgvaagpa sgtgssqegl qetrlaagdg pgvwaaetsg gnglgaaaar
       61 rslpdsaspa gspevpgpcs ssagldlkds glespaaaea plrgqykvta spetavagvg
      121 helgtagdag arpdlagtcq aeltaagsee pssagglsss csdpsppges psldslesfs
      181 nlhsfpssce fnseegaenr vpeeeegaav lpgavplcke eegeetaqvl aaskerfpgq
      241 svyhikwiqw keentpiitq nengpcplla ilnvlllawk vklppmmeii taeqlmeylg
      301 dymldakpke iseiqrlnye qihhccrfkk ssktlkgknn msdamailhk lqtgldvnvr
      361 ftgvrvfeyt pecivfdlld iplyhgwlvd pqgqlyllvt dqgflteekv vweslhnvdg
      421 dgnfcdsefh lrppsdpetv ykgqqdqidq dylmalslqq eqqsqeinwe qipegisdle
      481 lakklqeeed rrasqyyqeq eqaaaaaaaa stqaqqgqpa qaspssgrqs gnserkrkep
      541 rekdkekeke knscvil
//
LOCUS       XP_047288656             556 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin carboxyl-terminal hydrolase MINDY-2 isoform X8 [Homo
            sapiens].
ACCESSION   XP_047288656
VERSION     XP_047288656.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432700.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..556
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..556
                     /product="ubiquitin carboxyl-terminal hydrolase MINDY-2
                     isoform X8"
                     /calculated_mol_wt=59718
     Region          <19..>209
                     /region_name="PRK07003"
                     /note="DNA polymerase III subunit gamma/tau"
                     /db_xref="CDD:235906"
     Region          279..392
                     /region_name="MINDY_DUB"
                     /note="MINDY deubiquitinase; pfam04424"
                     /db_xref="CDD:461303"
     CDS             1..556
                     /gene="MINDY2"
                     /gene_synonym="FAM63B"
                     /coded_by="XM_047432700.1:95..1765"
                     /db_xref="GeneID:54629"
                     /db_xref="HGNC:HGNC:26954"
                     /db_xref="MIM:618408"
ORIGIN      
        1 messpeslqp lehgvaagpa sgtgssqegl qetrlaagdg pgvwaaetsg gnglgaaaar
       61 rslpdsaspa gspevpgpcs ssagldlkds glespaaaea plrgqykvta spetavagvg
      121 helgtagdag arpdlagtcq aeltaagsee pssagglsss csdpsppges psldslesfs
      181 nlhsfpssce fnseegaenr vpeeeegaav lpgavplcke eegeetaqvl aaskerfpgq
      241 svyhikwiqw keentpiitq nengpcplla ilnvlllawk vklppmmeii taeqlmeylg
      301 dymldakpke iseiqrlnye qihhccrfkk ssktlkgknn msdamailhk lqtgldvnvr
      361 ftgvrvfeyt pecivfdlld iplyhgwlvd pqgqlyllvt dqgflteekv vweslhnvdg
      421 dgnfcdsefh lrppsdpetv ykgqqdqidq dylmalslqq eqqsqeinwe qipegisdle
      481 lakklqeeed rrasqyyqeq eqaaaaaaaa stqaqgqpaq aspssgrqsg nserkrkepr
      541 ekdkekekek nscvil
//
LOCUS       XP_016877822             539 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin carboxyl-terminal hydrolase MINDY-2 isoform X9 [Homo
            sapiens].
ACCESSION   XP_016877822
VERSION     XP_016877822.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022333.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..539
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..539
                     /product="ubiquitin carboxyl-terminal hydrolase MINDY-2
                     isoform X9"
                     /calculated_mol_wt=57749
     Region          <19..>209
                     /region_name="PRK07003"
                     /note="DNA polymerase III subunit gamma/tau"
                     /db_xref="CDD:235906"
     Region          279..374
                     /region_name="MINDY_DUB"
                     /note="MINDY deubiquitinase; pfam04424"
                     /db_xref="CDD:461303"
     CDS             1..539
                     /gene="MINDY2"
                     /gene_synonym="FAM63B"
                     /coded_by="XM_017022333.3:95..1714"
                     /db_xref="GeneID:54629"
                     /db_xref="HGNC:HGNC:26954"
                     /db_xref="MIM:618408"
ORIGIN      
        1 messpeslqp lehgvaagpa sgtgssqegl qetrlaagdg pgvwaaetsg gnglgaaaar
       61 rslpdsaspa gspevpgpcs ssagldlkds glespaaaea plrgqykvta spetavagvg
      121 helgtagdag arpdlagtcq aeltaagsee pssagglsss csdpsppges psldslesfs
      181 nlhsfpssce fnseegaenr vpeeeegaav lpgavplcke eegeetaqvl aaskerfpgq
      241 svyhikwiqw keentpiitq nengpcplla ilnvlllawk vklppmmeii taeqlmeylg
      301 dymldakpke iseiqrlnye qnmsdamail hklqtgldvn vrftgvrvfe ytpecivfdl
      361 ldiplyhgwl vdpqgqlyll vtdqgfltee kvvweslhnv dgdgnfcdse fhlrppsdpe
      421 tvykgqqdqi dqdylmalsl qqeqqsqein weqipegisd lelakklqee edrrasqyyq
      481 eqeqaaaaaa aastqaqqgq paqaspssgr qsgnserkrk eprekdkeke keknscvil
//
LOCUS       XP_016877823             538 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin carboxyl-terminal hydrolase MINDY-2 isoform X10 [Homo
            sapiens].
ACCESSION   XP_016877823
VERSION     XP_016877823.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022334.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..538
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..538
                     /product="ubiquitin carboxyl-terminal hydrolase MINDY-2
                     isoform X10"
                     /calculated_mol_wt=57621
     Region          <19..>209
                     /region_name="PRK07003"
                     /note="DNA polymerase III subunit gamma/tau"
                     /db_xref="CDD:235906"
     Region          279..374
                     /region_name="MINDY_DUB"
                     /note="MINDY deubiquitinase; pfam04424"
                     /db_xref="CDD:461303"
     CDS             1..538
                     /gene="MINDY2"
                     /gene_synonym="FAM63B"
                     /coded_by="XM_017022334.3:95..1711"
                     /db_xref="GeneID:54629"
                     /db_xref="HGNC:HGNC:26954"
                     /db_xref="MIM:618408"
ORIGIN      
        1 messpeslqp lehgvaagpa sgtgssqegl qetrlaagdg pgvwaaetsg gnglgaaaar
       61 rslpdsaspa gspevpgpcs ssagldlkds glespaaaea plrgqykvta spetavagvg
      121 helgtagdag arpdlagtcq aeltaagsee pssagglsss csdpsppges psldslesfs
      181 nlhsfpssce fnseegaenr vpeeeegaav lpgavplcke eegeetaqvl aaskerfpgq
      241 svyhikwiqw keentpiitq nengpcplla ilnvlllawk vklppmmeii taeqlmeylg
      301 dymldakpke iseiqrlnye qnmsdamail hklqtgldvn vrftgvrvfe ytpecivfdl
      361 ldiplyhgwl vdpqgqlyll vtdqgfltee kvvweslhnv dgdgnfcdse fhlrppsdpe
      421 tvykgqqdqi dqdylmalsl qqeqqsqein weqipegisd lelakklqee edrrasqyyq
      481 eqeqaaaaaa aastqaqgqp aqaspssgrq sgnserkrke prekdkekek eknscvil
//
LOCUS       XP_016877824             394 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin carboxyl-terminal hydrolase MINDY-2 isoform X11 [Homo
            sapiens].
ACCESSION   XP_016877824
VERSION     XP_016877824.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022335.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..394
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..394
                     /product="ubiquitin carboxyl-terminal hydrolase MINDY-2
                     isoform X11"
                     /calculated_mol_wt=41347
     Region          <19..>209
                     /region_name="PRK07003"
                     /note="DNA polymerase III subunit gamma/tau"
                     /db_xref="CDD:235906"
     Region          279..392
                     /region_name="MINDY_DUB"
                     /note="MINDY deubiquitinase; pfam04424"
                     /db_xref="CDD:461303"
     CDS             1..394
                     /gene="MINDY2"
                     /gene_synonym="FAM63B"
                     /coded_by="XM_017022335.3:95..1279"
                     /db_xref="GeneID:54629"
                     /db_xref="HGNC:HGNC:26954"
                     /db_xref="MIM:618408"
ORIGIN      
        1 messpeslqp lehgvaagpa sgtgssqegl qetrlaagdg pgvwaaetsg gnglgaaaar
       61 rslpdsaspa gspevpgpcs ssagldlkds glespaaaea plrgqykvta spetavagvg
      121 helgtagdag arpdlagtcq aeltaagsee pssagglsss csdpsppges psldslesfs
      181 nlhsfpssce fnseegaenr vpeeeegaav lpgavplcke eegeetaqvl aaskerfpgq
      241 svyhikwiqw keentpiitq nengpcplla ilnvlllawk vklppmmeii taeqlmeylg
      301 dymldakpke iseiqrlnye qihhccrfkk ssktlkgknn msdamailhk lqtgldvnvr
      361 ftgvrvfeyt pecivfdlld iplyhgwlvd pqal
//
LOCUS       XP_047288657            1056 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase Arkadia isoform X1 [Homo sapiens].
ACCESSION   XP_047288657
VERSION     XP_047288657.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432701.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1056
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1056
                     /product="E3 ubiquitin-protein ligase Arkadia isoform X1"
                     /calculated_mol_wt=115683
     Region          71..345
                     /region_name="RNF111_N"
                     /note="E3 ubiquitin-protein ligase Arkadia N-terminus;
                     pfam15303"
                     /db_xref="CDD:464629"
     Region          452..>583
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          992..1052
                     /region_name="RING-H2_RNF111"
                     /note="RING finger, H2 subclass, found in RING finger
                     protein 111 (RNF111) and similar proteins; cd16681"
                     /db_xref="CDD:438343"
     CDS             1..1056
                     /gene="RNF111"
                     /gene_synonym="ARK; hRNF111"
                     /coded_by="XM_047432701.1:530..3700"
                     /db_xref="GeneID:54778"
                     /db_xref="HGNC:HGNC:17384"
                     /db_xref="MIM:605840"
ORIGIN      
        1 mhvfslidgs sglavlsmss niqtnmewrm slnlltwlsl vqssfnklsl kfpmsqwtpe
       61 ynelytlkvd mkseipsdap ktqeslkgil lhpepigaak sfpagvemin skvgnefshl
      121 cddsqkqeke mngnqqeqek slvvrkkrks qqagpsyvqn cvkenqgilg lrqhlgtpsd
      181 edndssfsdc lsspssslhf gdsdtvtsde dkevsvrhsq tilnaksrsh sarshkwprt
      241 etesvsgllm krpclhgssl rrlpcrkrfv knnssqrtqk qkerilmqrk krevlarrky
      301 allpssssss endlssesss ssstegeedl fvsasenhqn npavpsgsid edvvvieass
      361 tpqvtaneei nvtstdseve ivtvgesyrs rstlghsrsh wsqgssshas rpqeprnrsr
      421 istviqplrq naaevvdltv dedeptvvpt tsarmesqat sasinnsnps tseqasdtas
      481 avtssqpstv setsatltsn sttgtsigdd srrttssavt etgppamprl psccpqhspc
      541 ggssqnhhal ghphtscfqq hghhfqhhhh hhhtphpavp vspsfsdpac pverppqvqa
      601 pcgansssgt syheqqalpv dlsnsgirsh gsgsfhgasa fdpccpvsss raaifghqaa
      661 aaapsqplss idgygssmva qpqpqpppqp slsscrhymp ppyasltrpl hhqasacphs
      721 hgnpppqtqp ppqvdyviph pvhafhsqis shatshpvap pppthlasta apipqhlppt
      781 hqpishhipa tappaqrlhp hevmqrmevq rrrmmqhptg lfvfcvsrra herppphphr
      841 mhpnyghghh ihvpqtmssh prqapersaw elgieagvta atytpgalhp hlahyhappr
      901 lhhlqlgalp lmvpdmagyp hiryissgld gtsfrgpfrg nfeelihlee rlgnvnrgas
      961 qgtierctyp hkykkvttdw fsqrklhckq dgeegteedt eekcticlsi leegedvrrl
     1021 pcmhlfhqvc vdqwlitnkk cpicrvdiea qlpses
//
LOCUS       XP_047288658            1056 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase Arkadia isoform X1 [Homo sapiens].
ACCESSION   XP_047288658
VERSION     XP_047288658.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432702.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1056
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1056
                     /product="E3 ubiquitin-protein ligase Arkadia isoform X1"
                     /calculated_mol_wt=115683
     Region          71..345
                     /region_name="RNF111_N"
                     /note="E3 ubiquitin-protein ligase Arkadia N-terminus;
                     pfam15303"
                     /db_xref="CDD:464629"
     Region          452..>583
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          992..1052
                     /region_name="RING-H2_RNF111"
                     /note="RING finger, H2 subclass, found in RING finger
                     protein 111 (RNF111) and similar proteins; cd16681"
                     /db_xref="CDD:438343"
     CDS             1..1056
                     /gene="RNF111"
                     /gene_synonym="ARK; hRNF111"
                     /coded_by="XM_047432702.1:563..3733"
                     /db_xref="GeneID:54778"
                     /db_xref="HGNC:HGNC:17384"
                     /db_xref="MIM:605840"
ORIGIN      
        1 mhvfslidgs sglavlsmss niqtnmewrm slnlltwlsl vqssfnklsl kfpmsqwtpe
       61 ynelytlkvd mkseipsdap ktqeslkgil lhpepigaak sfpagvemin skvgnefshl
      121 cddsqkqeke mngnqqeqek slvvrkkrks qqagpsyvqn cvkenqgilg lrqhlgtpsd
      181 edndssfsdc lsspssslhf gdsdtvtsde dkevsvrhsq tilnaksrsh sarshkwprt
      241 etesvsgllm krpclhgssl rrlpcrkrfv knnssqrtqk qkerilmqrk krevlarrky
      301 allpssssss endlssesss ssstegeedl fvsasenhqn npavpsgsid edvvvieass
      361 tpqvtaneei nvtstdseve ivtvgesyrs rstlghsrsh wsqgssshas rpqeprnrsr
      421 istviqplrq naaevvdltv dedeptvvpt tsarmesqat sasinnsnps tseqasdtas
      481 avtssqpstv setsatltsn sttgtsigdd srrttssavt etgppamprl psccpqhspc
      541 ggssqnhhal ghphtscfqq hghhfqhhhh hhhtphpavp vspsfsdpac pverppqvqa
      601 pcgansssgt syheqqalpv dlsnsgirsh gsgsfhgasa fdpccpvsss raaifghqaa
      661 aaapsqplss idgygssmva qpqpqpppqp slsscrhymp ppyasltrpl hhqasacphs
      721 hgnpppqtqp ppqvdyviph pvhafhsqis shatshpvap pppthlasta apipqhlppt
      781 hqpishhipa tappaqrlhp hevmqrmevq rrrmmqhptg lfvfcvsrra herppphphr
      841 mhpnyghghh ihvpqtmssh prqapersaw elgieagvta atytpgalhp hlahyhappr
      901 lhhlqlgalp lmvpdmagyp hiryissgld gtsfrgpfrg nfeelihlee rlgnvnrgas
      961 qgtierctyp hkykkvttdw fsqrklhckq dgeegteedt eekcticlsi leegedvrrl
     1021 pcmhlfhqvc vdqwlitnkk cpicrvdiea qlpses
//
LOCUS       XP_047288659            1056 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase Arkadia isoform X1 [Homo sapiens].
ACCESSION   XP_047288659
VERSION     XP_047288659.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432703.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1056
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1056
                     /product="E3 ubiquitin-protein ligase Arkadia isoform X1"
                     /calculated_mol_wt=115683
     Region          71..345
                     /region_name="RNF111_N"
                     /note="E3 ubiquitin-protein ligase Arkadia N-terminus;
                     pfam15303"
                     /db_xref="CDD:464629"
     Region          452..>583
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          992..1052
                     /region_name="RING-H2_RNF111"
                     /note="RING finger, H2 subclass, found in RING finger
                     protein 111 (RNF111) and similar proteins; cd16681"
                     /db_xref="CDD:438343"
     CDS             1..1056
                     /gene="RNF111"
                     /gene_synonym="ARK; hRNF111"
                     /coded_by="XM_047432703.1:425..3595"
                     /db_xref="GeneID:54778"
                     /db_xref="HGNC:HGNC:17384"
                     /db_xref="MIM:605840"
ORIGIN      
        1 mhvfslidgs sglavlsmss niqtnmewrm slnlltwlsl vqssfnklsl kfpmsqwtpe
       61 ynelytlkvd mkseipsdap ktqeslkgil lhpepigaak sfpagvemin skvgnefshl
      121 cddsqkqeke mngnqqeqek slvvrkkrks qqagpsyvqn cvkenqgilg lrqhlgtpsd
      181 edndssfsdc lsspssslhf gdsdtvtsde dkevsvrhsq tilnaksrsh sarshkwprt
      241 etesvsgllm krpclhgssl rrlpcrkrfv knnssqrtqk qkerilmqrk krevlarrky
      301 allpssssss endlssesss ssstegeedl fvsasenhqn npavpsgsid edvvvieass
      361 tpqvtaneei nvtstdseve ivtvgesyrs rstlghsrsh wsqgssshas rpqeprnrsr
      421 istviqplrq naaevvdltv dedeptvvpt tsarmesqat sasinnsnps tseqasdtas
      481 avtssqpstv setsatltsn sttgtsigdd srrttssavt etgppamprl psccpqhspc
      541 ggssqnhhal ghphtscfqq hghhfqhhhh hhhtphpavp vspsfsdpac pverppqvqa
      601 pcgansssgt syheqqalpv dlsnsgirsh gsgsfhgasa fdpccpvsss raaifghqaa
      661 aaapsqplss idgygssmva qpqpqpppqp slsscrhymp ppyasltrpl hhqasacphs
      721 hgnpppqtqp ppqvdyviph pvhafhsqis shatshpvap pppthlasta apipqhlppt
      781 hqpishhipa tappaqrlhp hevmqrmevq rrrmmqhptg lfvfcvsrra herppphphr
      841 mhpnyghghh ihvpqtmssh prqapersaw elgieagvta atytpgalhp hlahyhappr
      901 lhhlqlgalp lmvpdmagyp hiryissgld gtsfrgpfrg nfeelihlee rlgnvnrgas
      961 qgtierctyp hkykkvttdw fsqrklhckq dgeegteedt eekcticlsi leegedvrrl
     1021 pcmhlfhqvc vdqwlitnkk cpicrvdiea qlpses
//
LOCUS       XP_047288660            1056 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase Arkadia isoform X1 [Homo sapiens].
ACCESSION   XP_047288660
VERSION     XP_047288660.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432704.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1056
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1056
                     /product="E3 ubiquitin-protein ligase Arkadia isoform X1"
                     /calculated_mol_wt=115683
     Region          71..345
                     /region_name="RNF111_N"
                     /note="E3 ubiquitin-protein ligase Arkadia N-terminus;
                     pfam15303"
                     /db_xref="CDD:464629"
     Region          452..>583
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          992..1052
                     /region_name="RING-H2_RNF111"
                     /note="RING finger, H2 subclass, found in RING finger
                     protein 111 (RNF111) and similar proteins; cd16681"
                     /db_xref="CDD:438343"
     CDS             1..1056
                     /gene="RNF111"
                     /gene_synonym="ARK; hRNF111"
                     /coded_by="XM_047432704.1:392..3562"
                     /db_xref="GeneID:54778"
                     /db_xref="HGNC:HGNC:17384"
                     /db_xref="MIM:605840"
ORIGIN      
        1 mhvfslidgs sglavlsmss niqtnmewrm slnlltwlsl vqssfnklsl kfpmsqwtpe
       61 ynelytlkvd mkseipsdap ktqeslkgil lhpepigaak sfpagvemin skvgnefshl
      121 cddsqkqeke mngnqqeqek slvvrkkrks qqagpsyvqn cvkenqgilg lrqhlgtpsd
      181 edndssfsdc lsspssslhf gdsdtvtsde dkevsvrhsq tilnaksrsh sarshkwprt
      241 etesvsgllm krpclhgssl rrlpcrkrfv knnssqrtqk qkerilmqrk krevlarrky
      301 allpssssss endlssesss ssstegeedl fvsasenhqn npavpsgsid edvvvieass
      361 tpqvtaneei nvtstdseve ivtvgesyrs rstlghsrsh wsqgssshas rpqeprnrsr
      421 istviqplrq naaevvdltv dedeptvvpt tsarmesqat sasinnsnps tseqasdtas
      481 avtssqpstv setsatltsn sttgtsigdd srrttssavt etgppamprl psccpqhspc
      541 ggssqnhhal ghphtscfqq hghhfqhhhh hhhtphpavp vspsfsdpac pverppqvqa
      601 pcgansssgt syheqqalpv dlsnsgirsh gsgsfhgasa fdpccpvsss raaifghqaa
      661 aaapsqplss idgygssmva qpqpqpppqp slsscrhymp ppyasltrpl hhqasacphs
      721 hgnpppqtqp ppqvdyviph pvhafhsqis shatshpvap pppthlasta apipqhlppt
      781 hqpishhipa tappaqrlhp hevmqrmevq rrrmmqhptg lfvfcvsrra herppphphr
      841 mhpnyghghh ihvpqtmssh prqapersaw elgieagvta atytpgalhp hlahyhappr
      901 lhhlqlgalp lmvpdmagyp hiryissgld gtsfrgpfrg nfeelihlee rlgnvnrgas
      961 qgtierctyp hkykkvttdw fsqrklhckq dgeegteedt eekcticlsi leegedvrrl
     1021 pcmhlfhqvc vdqwlitnkk cpicrvdiea qlpses
//
LOCUS       XP_047288661            1055 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase Arkadia isoform X2 [Homo sapiens].
ACCESSION   XP_047288661
VERSION     XP_047288661.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432705.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1055
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1055
                     /product="E3 ubiquitin-protein ligase Arkadia isoform X2"
                     /calculated_mol_wt=115555
     Region          71..345
                     /region_name="RNF111_N"
                     /note="E3 ubiquitin-protein ligase Arkadia N-terminus;
                     pfam15303"
                     /db_xref="CDD:464629"
     Region          452..>583
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          <577..799
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          991..1051
                     /region_name="RING-H2_RNF111"
                     /note="RING finger, H2 subclass, found in RING finger
                     protein 111 (RNF111) and similar proteins; cd16681"
                     /db_xref="CDD:438343"
     CDS             1..1055
                     /gene="RNF111"
                     /gene_synonym="ARK; hRNF111"
                     /coded_by="XM_047432705.1:530..3697"
                     /db_xref="GeneID:54778"
                     /db_xref="HGNC:HGNC:17384"
                     /db_xref="MIM:605840"
ORIGIN      
        1 mhvfslidgs sglavlsmss niqtnmewrm slnlltwlsl vqssfnklsl kfpmsqwtpe
       61 ynelytlkvd mkseipsdap ktqeslkgil lhpepigaak sfpagvemin skvgnefshl
      121 cddsqkqeke mngnqqeqek slvvrkkrks qqagpsyvqn cvkenqgilg lrqhlgtpsd
      181 edndssfsdc lsspssslhf gdsdtvtsde dkevsvrhsq tilnaksrsh sarshkwprt
      241 etesvsgllm krpclhgssl rrlpcrkrfv knnssqrtqk qkerilmqrk krevlarrky
      301 allpssssss endlssesss ssstegeedl fvsasenhqn npavpsgsid edvvvieass
      361 tpqvtaneei nvtstdseve ivtvgesyrs rstlghsrsh wsqgssshas rpqeprnrsr
      421 istviqplrq naaevvdltv dedeptvvpt tsarmesqat sasinnsnps tseqasdtas
      481 avtssqpstv setsatltsn sttgtsigdd srrttssavt etgppamprl psccpqhspc
      541 ggssqnhhal ghphtscfqq hghhfqhhhh hhhtphpavp vspsfsdpac pverppqvqa
      601 pcgansssgt syheqalpvd lsnsgirshg sgsfhgasaf dpccpvsssr aaifghqaaa
      661 aapsqplssi dgygssmvaq pqpqpppqps lsscrhympp pyasltrplh hqasacphsh
      721 gnpppqtqpp pqvdyviphp vhafhsqiss hatshpvapp ppthlastaa pipqhlppth
      781 qpishhipat appaqrlhph evmqrmevqr rrmmqhptgl fvfcvsrrah erppphphrm
      841 hpnyghghhi hvpqtmsshp rqapersawe lgieagvtaa tytpgalhph lahyhapprl
      901 hhlqlgalpl mvpdmagyph iryissgldg tsfrgpfrgn feelihleer lgnvnrgasq
      961 gtierctyph kykkvttdwf sqrklhckqd geegteedte ekcticlsil eegedvrrlp
     1021 cmhlfhqvcv dqwlitnkkc picrvdieaq lpses
//
LOCUS       XP_047288662            1048 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase Arkadia isoform X3 [Homo sapiens].
ACCESSION   XP_047288662
VERSION     XP_047288662.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432706.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1048
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1048
                     /product="E3 ubiquitin-protein ligase Arkadia isoform X3"
                     /calculated_mol_wt=114718
     Region          71..345
                     /region_name="RNF111_N"
                     /note="E3 ubiquitin-protein ligase Arkadia N-terminus;
                     pfam15303"
                     /db_xref="CDD:464629"
     Region          452..>583
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          984..1044
                     /region_name="RING-H2_RNF111"
                     /note="RING finger, H2 subclass, found in RING finger
                     protein 111 (RNF111) and similar proteins; cd16681"
                     /db_xref="CDD:438343"
     CDS             1..1048
                     /gene="RNF111"
                     /gene_synonym="ARK; hRNF111"
                     /coded_by="XM_047432706.1:530..3676"
                     /db_xref="GeneID:54778"
                     /db_xref="HGNC:HGNC:17384"
                     /db_xref="MIM:605840"
ORIGIN      
        1 mhvfslidgs sglavlsmss niqtnmewrm slnlltwlsl vqssfnklsl kfpmsqwtpe
       61 ynelytlkvd mkseipsdap ktqeslkgil lhpepigaak sfpagvemin skvgnefshl
      121 cddsqkqeke mngnqqeqek slvvrkkrks qqagpsyvqn cvkenqgilg lrqhlgtpsd
      181 edndssfsdc lsspssslhf gdsdtvtsde dkevsvrhsq tilnaksrsh sarshkwprt
      241 etesvsgllm krpclhgssl rrlpcrkrfv knnssqrtqk qkerilmqrk krevlarrky
      301 allpssssss endlssesss ssstegeedl fvsasenhqn npavpsgsid edvvvieass
      361 tpqvtaneei nvtstdseve ivtvgesyrs rstlghsrsh wsqgssshas rpqeprnrsr
      421 istviqplrq naaevvdltv dedeptvvpt tsarmesqat sasinnsnps tseqasdtas
      481 avtssqpstv setsatltsn sttgtsigdd srrttssavt etgppamprl psccpqhspc
      541 ggssqnhhal ghphtscfqq hghhfqhhhh hhhtphpavp vspsfsdpac pverppqvqa
      601 pcgansssgt syheqqalpv dlsnsgirsh gsgsfhgasa fdpccpvsss raaifghqaa
      661 aaapsqplss idgygssmva qpqpqpppqp slsscrhymp ppyasltrpl hhqasacphs
      721 hgnpppqtqp ppqvdyviph pvhafhsqis shatshpvap pppthlasta apipqhlppt
      781 hqpishhipa tappaqrlhp hevmqrmevq rrrmmqhptg lfvfcvsrra herppphphr
      841 mhpnyghghh ihvpqtmssh prqapersaw elgieagvta atytpgalhp hlahyhappr
      901 lhhlqlgalp lmvpdmagyp hiryissgld gtsfrgpfrg nfeelihlee rlgnvnrgas
      961 qgtierctyp hkykkrklhc kqdgeegtee dteekcticl sileegedvr rlpcmhlfhq
     1021 vcvdqwlitn kkcpicrvdi eaqlpses
//
LOCUS       XP_047288663            1047 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase Arkadia isoform X4 [Homo sapiens].
ACCESSION   XP_047288663
VERSION     XP_047288663.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432707.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1047
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1047
                     /product="E3 ubiquitin-protein ligase Arkadia isoform X4"
                     /calculated_mol_wt=114674
     Region          71..345
                     /region_name="RNF111_N"
                     /note="E3 ubiquitin-protein ligase Arkadia N-terminus;
                     pfam15303"
                     /db_xref="CDD:464629"
     Region          452..>583
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          983..1043
                     /region_name="RING-H2_RNF111"
                     /note="RING finger, H2 subclass, found in RING finger
                     protein 111 (RNF111) and similar proteins; cd16681"
                     /db_xref="CDD:438343"
     CDS             1..1047
                     /gene="RNF111"
                     /gene_synonym="ARK; hRNF111"
                     /coded_by="XM_047432707.1:530..3673"
                     /db_xref="GeneID:54778"
                     /db_xref="HGNC:HGNC:17384"
                     /db_xref="MIM:605840"
ORIGIN      
        1 mhvfslidgs sglavlsmss niqtnmewrm slnlltwlsl vqssfnklsl kfpmsqwtpe
       61 ynelytlkvd mkseipsdap ktqeslkgil lhpepigaak sfpagvemin skvgnefshl
      121 cddsqkqeke mngnqqeqek slvvrkkrks qqagpsyvqn cvkenqgilg lrqhlgtpsd
      181 edndssfsdc lsspssslhf gdsdtvtsde dkevsvrhsq tilnaksrsh sarshkwprt
      241 etesvsgllm krpclhgssl rrlpcrkrfv knnssqrtqk qkerilmqrk krevlarrky
      301 allpssssss endlssesss ssstegeedl fvsasenhqn npavpsgsid edvvvieass
      361 tpqvtaneei nvtstdseve ivtvgesyrs rstlghsrsh wsqgssshas rpqeprnrsr
      421 istviqplrq naaevvdltv dedeptvvpt tsarmesqat sasinnsnps tseqasdtas
      481 avtssqpstv setsatltsn sttgtsigdd srrttssavt etgppamprl psccpqhspc
      541 ggssqnhhal ghphtscfqq hghhfqhhhh hhhtphpavp vspsfsdpac pverppqvqa
      601 pcgansssgt syheqqalpv dlsnsgirsh gsgsfhgasa fdpccpvsss raaifghqaa
      661 aaapsqplss idgygssmva qpqpqpppqp slsscrhymp ppyasltrpl hhqasacphs
      721 hgnpppqtqp ppqvdyviph pvhafhsqis shatshpvap pppthlasta apipqhlppt
      781 hqpishhipa tappaqrlhp hevmqrmevq rrrmmqhptr aherppphph rmhpnyghgh
      841 hihvpqtmss hprqapersa welgieagvt aatytpgalh phlahyhapp rlhhlqlgal
      901 plmvpdmagy phiryissgl dgtsfrgpfr gnfeelihle erlgnvnrga sqgtiercty
      961 phkykkvttd wfsqrklhck qdgeegteed teekcticls ileegedvrr lpcmhlfhqv
     1021 cvdqwlitnk kcpicrvdie aqlpses
//
LOCUS       XP_047288664            1047 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase Arkadia isoform X4 [Homo sapiens].
ACCESSION   XP_047288664
VERSION     XP_047288664.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432708.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1047
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1047
                     /product="E3 ubiquitin-protein ligase Arkadia isoform X4"
                     /calculated_mol_wt=114674
     Region          71..345
                     /region_name="RNF111_N"
                     /note="E3 ubiquitin-protein ligase Arkadia N-terminus;
                     pfam15303"
                     /db_xref="CDD:464629"
     Region          452..>583
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          983..1043
                     /region_name="RING-H2_RNF111"
                     /note="RING finger, H2 subclass, found in RING finger
                     protein 111 (RNF111) and similar proteins; cd16681"
                     /db_xref="CDD:438343"
     CDS             1..1047
                     /gene="RNF111"
                     /gene_synonym="ARK; hRNF111"
                     /coded_by="XM_047432708.1:563..3706"
                     /db_xref="GeneID:54778"
                     /db_xref="HGNC:HGNC:17384"
                     /db_xref="MIM:605840"
ORIGIN      
        1 mhvfslidgs sglavlsmss niqtnmewrm slnlltwlsl vqssfnklsl kfpmsqwtpe
       61 ynelytlkvd mkseipsdap ktqeslkgil lhpepigaak sfpagvemin skvgnefshl
      121 cddsqkqeke mngnqqeqek slvvrkkrks qqagpsyvqn cvkenqgilg lrqhlgtpsd
      181 edndssfsdc lsspssslhf gdsdtvtsde dkevsvrhsq tilnaksrsh sarshkwprt
      241 etesvsgllm krpclhgssl rrlpcrkrfv knnssqrtqk qkerilmqrk krevlarrky
      301 allpssssss endlssesss ssstegeedl fvsasenhqn npavpsgsid edvvvieass
      361 tpqvtaneei nvtstdseve ivtvgesyrs rstlghsrsh wsqgssshas rpqeprnrsr
      421 istviqplrq naaevvdltv dedeptvvpt tsarmesqat sasinnsnps tseqasdtas
      481 avtssqpstv setsatltsn sttgtsigdd srrttssavt etgppamprl psccpqhspc
      541 ggssqnhhal ghphtscfqq hghhfqhhhh hhhtphpavp vspsfsdpac pverppqvqa
      601 pcgansssgt syheqqalpv dlsnsgirsh gsgsfhgasa fdpccpvsss raaifghqaa
      661 aaapsqplss idgygssmva qpqpqpppqp slsscrhymp ppyasltrpl hhqasacphs
      721 hgnpppqtqp ppqvdyviph pvhafhsqis shatshpvap pppthlasta apipqhlppt
      781 hqpishhipa tappaqrlhp hevmqrmevq rrrmmqhptr aherppphph rmhpnyghgh
      841 hihvpqtmss hprqapersa welgieagvt aatytpgalh phlahyhapp rlhhlqlgal
      901 plmvpdmagy phiryissgl dgtsfrgpfr gnfeelihle erlgnvnrga sqgtiercty
      961 phkykkvttd wfsqrklhck qdgeegteed teekcticls ileegedvrr lpcmhlfhqv
     1021 cvdqwlitnk kcpicrvdie aqlpses
//
LOCUS       XP_047288665            1047 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase Arkadia isoform X5 [Homo sapiens].
ACCESSION   XP_047288665
VERSION     XP_047288665.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432709.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1047
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1047
                     /product="E3 ubiquitin-protein ligase Arkadia isoform X5"
                     /calculated_mol_wt=114590
     Region          71..345
                     /region_name="RNF111_N"
                     /note="E3 ubiquitin-protein ligase Arkadia N-terminus;
                     pfam15303"
                     /db_xref="CDD:464629"
     Region          452..>583
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          <577..799
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          983..1043
                     /region_name="RING-H2_RNF111"
                     /note="RING finger, H2 subclass, found in RING finger
                     protein 111 (RNF111) and similar proteins; cd16681"
                     /db_xref="CDD:438343"
     CDS             1..1047
                     /gene="RNF111"
                     /gene_synonym="ARK; hRNF111"
                     /coded_by="XM_047432709.1:530..3673"
                     /db_xref="GeneID:54778"
                     /db_xref="HGNC:HGNC:17384"
                     /db_xref="MIM:605840"
ORIGIN      
        1 mhvfslidgs sglavlsmss niqtnmewrm slnlltwlsl vqssfnklsl kfpmsqwtpe
       61 ynelytlkvd mkseipsdap ktqeslkgil lhpepigaak sfpagvemin skvgnefshl
      121 cddsqkqeke mngnqqeqek slvvrkkrks qqagpsyvqn cvkenqgilg lrqhlgtpsd
      181 edndssfsdc lsspssslhf gdsdtvtsde dkevsvrhsq tilnaksrsh sarshkwprt
      241 etesvsgllm krpclhgssl rrlpcrkrfv knnssqrtqk qkerilmqrk krevlarrky
      301 allpssssss endlssesss ssstegeedl fvsasenhqn npavpsgsid edvvvieass
      361 tpqvtaneei nvtstdseve ivtvgesyrs rstlghsrsh wsqgssshas rpqeprnrsr
      421 istviqplrq naaevvdltv dedeptvvpt tsarmesqat sasinnsnps tseqasdtas
      481 avtssqpstv setsatltsn sttgtsigdd srrttssavt etgppamprl psccpqhspc
      541 ggssqnhhal ghphtscfqq hghhfqhhhh hhhtphpavp vspsfsdpac pverppqvqa
      601 pcgansssgt syheqalpvd lsnsgirshg sgsfhgasaf dpccpvsssr aaifghqaaa
      661 aapsqplssi dgygssmvaq pqpqpppqps lsscrhympp pyasltrplh hqasacphsh
      721 gnpppqtqpp pqvdyviphp vhafhsqiss hatshpvapp ppthlastaa pipqhlppth
      781 qpishhipat appaqrlhph evmqrmevqr rrmmqhptgl fvfcvsrrah erppphphrm
      841 hpnyghghhi hvpqtmsshp rqapersawe lgieagvtaa tytpgalhph lahyhapprl
      901 hhlqlgalpl mvpdmagyph iryissgldg tsfrgpfrgn feelihleer lgnvnrgasq
      961 gtierctyph kykkrklhck qdgeegteed teekcticls ileegedvrr lpcmhlfhqv
     1021 cvdqwlitnk kcpicrvdie aqlpses
//
LOCUS       XP_047288666            1046 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase Arkadia isoform X6 [Homo sapiens].
ACCESSION   XP_047288666
VERSION     XP_047288666.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432710.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1046
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1046
                     /product="E3 ubiquitin-protein ligase Arkadia isoform X6"
                     /calculated_mol_wt=114546
     Region          71..345
                     /region_name="RNF111_N"
                     /note="E3 ubiquitin-protein ligase Arkadia N-terminus;
                     pfam15303"
                     /db_xref="CDD:464629"
     Region          452..>583
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          <577..799
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          982..1042
                     /region_name="RING-H2_RNF111"
                     /note="RING finger, H2 subclass, found in RING finger
                     protein 111 (RNF111) and similar proteins; cd16681"
                     /db_xref="CDD:438343"
     CDS             1..1046
                     /gene="RNF111"
                     /gene_synonym="ARK; hRNF111"
                     /coded_by="XM_047432710.1:530..3670"
                     /db_xref="GeneID:54778"
                     /db_xref="HGNC:HGNC:17384"
                     /db_xref="MIM:605840"
ORIGIN      
        1 mhvfslidgs sglavlsmss niqtnmewrm slnlltwlsl vqssfnklsl kfpmsqwtpe
       61 ynelytlkvd mkseipsdap ktqeslkgil lhpepigaak sfpagvemin skvgnefshl
      121 cddsqkqeke mngnqqeqek slvvrkkrks qqagpsyvqn cvkenqgilg lrqhlgtpsd
      181 edndssfsdc lsspssslhf gdsdtvtsde dkevsvrhsq tilnaksrsh sarshkwprt
      241 etesvsgllm krpclhgssl rrlpcrkrfv knnssqrtqk qkerilmqrk krevlarrky
      301 allpssssss endlssesss ssstegeedl fvsasenhqn npavpsgsid edvvvieass
      361 tpqvtaneei nvtstdseve ivtvgesyrs rstlghsrsh wsqgssshas rpqeprnrsr
      421 istviqplrq naaevvdltv dedeptvvpt tsarmesqat sasinnsnps tseqasdtas
      481 avtssqpstv setsatltsn sttgtsigdd srrttssavt etgppamprl psccpqhspc
      541 ggssqnhhal ghphtscfqq hghhfqhhhh hhhtphpavp vspsfsdpac pverppqvqa
      601 pcgansssgt syheqalpvd lsnsgirshg sgsfhgasaf dpccpvsssr aaifghqaaa
      661 aapsqplssi dgygssmvaq pqpqpppqps lsscrhympp pyasltrplh hqasacphsh
      721 gnpppqtqpp pqvdyviphp vhafhsqiss hatshpvapp ppthlastaa pipqhlppth
      781 qpishhipat appaqrlhph evmqrmevqr rrmmqhptra herppphphr mhpnyghghh
      841 ihvpqtmssh prqapersaw elgieagvta atytpgalhp hlahyhappr lhhlqlgalp
      901 lmvpdmagyp hiryissgld gtsfrgpfrg nfeelihlee rlgnvnrgas qgtierctyp
      961 hkykkvttdw fsqrklhckq dgeegteedt eekcticlsi leegedvrrl pcmhlfhqvc
     1021 vdqwlitnkk cpicrvdiea qlpses
//
LOCUS       XP_047288667            1039 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase Arkadia isoform X7 [Homo sapiens].
ACCESSION   XP_047288667
VERSION     XP_047288667.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432711.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1039
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1039
                     /product="E3 ubiquitin-protein ligase Arkadia isoform X7"
                     /calculated_mol_wt=113709
     Region          71..345
                     /region_name="RNF111_N"
                     /note="E3 ubiquitin-protein ligase Arkadia N-terminus;
                     pfam15303"
                     /db_xref="CDD:464629"
     Region          452..>583
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          975..1035
                     /region_name="RING-H2_RNF111"
                     /note="RING finger, H2 subclass, found in RING finger
                     protein 111 (RNF111) and similar proteins; cd16681"
                     /db_xref="CDD:438343"
     CDS             1..1039
                     /gene="RNF111"
                     /gene_synonym="ARK; hRNF111"
                     /coded_by="XM_047432711.1:530..3649"
                     /db_xref="GeneID:54778"
                     /db_xref="HGNC:HGNC:17384"
                     /db_xref="MIM:605840"
ORIGIN      
        1 mhvfslidgs sglavlsmss niqtnmewrm slnlltwlsl vqssfnklsl kfpmsqwtpe
       61 ynelytlkvd mkseipsdap ktqeslkgil lhpepigaak sfpagvemin skvgnefshl
      121 cddsqkqeke mngnqqeqek slvvrkkrks qqagpsyvqn cvkenqgilg lrqhlgtpsd
      181 edndssfsdc lsspssslhf gdsdtvtsde dkevsvrhsq tilnaksrsh sarshkwprt
      241 etesvsgllm krpclhgssl rrlpcrkrfv knnssqrtqk qkerilmqrk krevlarrky
      301 allpssssss endlssesss ssstegeedl fvsasenhqn npavpsgsid edvvvieass
      361 tpqvtaneei nvtstdseve ivtvgesyrs rstlghsrsh wsqgssshas rpqeprnrsr
      421 istviqplrq naaevvdltv dedeptvvpt tsarmesqat sasinnsnps tseqasdtas
      481 avtssqpstv setsatltsn sttgtsigdd srrttssavt etgppamprl psccpqhspc
      541 ggssqnhhal ghphtscfqq hghhfqhhhh hhhtphpavp vspsfsdpac pverppqvqa
      601 pcgansssgt syheqqalpv dlsnsgirsh gsgsfhgasa fdpccpvsss raaifghqaa
      661 aaapsqplss idgygssmva qpqpqpppqp slsscrhymp ppyasltrpl hhqasacphs
      721 hgnpppqtqp ppqvdyviph pvhafhsqis shatshpvap pppthlasta apipqhlppt
      781 hqpishhipa tappaqrlhp hevmqrmevq rrrmmqhptr aherppphph rmhpnyghgh
      841 hihvpqtmss hprqapersa welgieagvt aatytpgalh phlahyhapp rlhhlqlgal
      901 plmvpdmagy phiryissgl dgtsfrgpfr gnfeelihle erlgnvnrga sqgtiercty
      961 phkykkrklh ckqdgeegte edteekctic lsileegedv rrlpcmhlfh qvcvdqwlit
     1021 nkkcpicrvd ieaqlpses
//
LOCUS       XP_047288668            1038 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase Arkadia isoform X8 [Homo sapiens].
ACCESSION   XP_047288668
VERSION     XP_047288668.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432712.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1038
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1038
                     /product="E3 ubiquitin-protein ligase Arkadia isoform X8"
                     /calculated_mol_wt=113581
     Region          71..345
                     /region_name="RNF111_N"
                     /note="E3 ubiquitin-protein ligase Arkadia N-terminus;
                     pfam15303"
                     /db_xref="CDD:464629"
     Region          452..>583
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          974..1034
                     /region_name="RING-H2_RNF111"
                     /note="RING finger, H2 subclass, found in RING finger
                     protein 111 (RNF111) and similar proteins; cd16681"
                     /db_xref="CDD:438343"
     CDS             1..1038
                     /gene="RNF111"
                     /gene_synonym="ARK; hRNF111"
                     /coded_by="XM_047432712.1:530..3646"
                     /db_xref="GeneID:54778"
                     /db_xref="HGNC:HGNC:17384"
                     /db_xref="MIM:605840"
ORIGIN      
        1 mhvfslidgs sglavlsmss niqtnmewrm slnlltwlsl vqssfnklsl kfpmsqwtpe
       61 ynelytlkvd mkseipsdap ktqeslkgil lhpepigaak sfpagvemin skvgnefshl
      121 cddsqkqeke mngnqqeqek slvvrkkrks qqagpsyvqn cvkenqgilg lrqhlgtpsd
      181 edndssfsdc lsspssslhf gdsdtvtsde dkevsvrhsq tilnaksrsh sarshkwprt
      241 etesvsgllm krpclhgssl rrlpcrkrfv knnssqrtqk qkerilmqrk krevlarrky
      301 allpssssss endlssesss ssstegeedl fvsasenhqn npavpsgsid edvvvieass
      361 tpqvtaneei nvtstdseve ivtvgesyrs rstlghsrsh wsqgssshas rpqeprnrsr
      421 istviqplrq naaevvdltv dedeptvvpt tsarmesqat sasinnsnps tseqasdtas
      481 avtssqpstv setsatltsn sttgtsigdd srrttssavt etgppamprl psccpqhspc
      541 ggssqnhhal ghphtscfqq hghhfqhhhh hhhtphpavp vspsfsdpac pverppqvqa
      601 pcgansssgt syheqalpvd lsnsgirshg sgsfhgasaf dpccpvsssr aaifghqaaa
      661 aapsqplssi dgygssmvaq pqpqpppqps lsscrhympp pyasltrplh hqasacphsh
      721 gnpppqtqpp pqvdyviphp vhafhsqiss hatshpvapp ppthlastaa pipqhlppth
      781 qpishhipat appaqrlhph evmqrmevqr rrmmqhptra herppphphr mhpnyghghh
      841 ihvpqtmssh prqapersaw elgieagvta atytpgalhp hlahyhappr lhhlqlgalp
      901 lmvpdmagyp hiryissgld gtsfrgpfrg nfeelihlee rlgnvnrgas qgtierctyp
      961 hkykkrklhc kqdgeegtee dteekcticl sileegedvr rlpcmhlfhq vcvdqwlitn
     1021 kkcpicrvdi eaqlpses
//
LOCUS       XP_006720638            1026 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase Arkadia isoform X9 [Homo sapiens].
ACCESSION   XP_006720638
VERSION     XP_006720638.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720575.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1026
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1026
                     /product="E3 ubiquitin-protein ligase Arkadia isoform X9"
                     /calculated_mol_wt=112210
     Region          41..315
                     /region_name="RNF111_N"
                     /note="E3 ubiquitin-protein ligase Arkadia N-terminus;
                     pfam15303"
                     /db_xref="CDD:464629"
     Region          422..>553
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          962..1022
                     /region_name="RING-H2_RNF111"
                     /note="RING finger, H2 subclass, found in RING finger
                     protein 111 (RNF111) and similar proteins; cd16681"
                     /db_xref="CDD:438343"
     CDS             1..1026
                     /gene="RNF111"
                     /gene_synonym="ARK; hRNF111"
                     /coded_by="XM_006720575.4:530..3610"
                     /db_xref="GeneID:54778"
                     /db_xref="HGNC:HGNC:17384"
                     /db_xref="MIM:605840"
ORIGIN      
        1 mhvfslidgs sglavlrlsl kfpmsqwtpe ynelytlkvd mkseipsdap ktqeslkgil
       61 lhpepigaak sfpagvemin skvgnefshl cddsqkqeke mngnqqeqek slvvrkkrks
      121 qqagpsyvqn cvkenqgilg lrqhlgtpsd edndssfsdc lsspssslhf gdsdtvtsde
      181 dkevsvrhsq tilnaksrsh sarshkwprt etesvsgllm krpclhgssl rrlpcrkrfv
      241 knnssqrtqk qkerilmqrk krevlarrky allpssssss endlssesss ssstegeedl
      301 fvsasenhqn npavpsgsid edvvvieass tpqvtaneei nvtstdseve ivtvgesyrs
      361 rstlghsrsh wsqgssshas rpqeprnrsr istviqplrq naaevvdltv dedeptvvpt
      421 tsarmesqat sasinnsnps tseqasdtas avtssqpstv setsatltsn sttgtsigdd
      481 srrttssavt etgppamprl psccpqhspc ggssqnhhal ghphtscfqq hghhfqhhhh
      541 hhhtphpavp vspsfsdpac pverppqvqa pcgansssgt syheqqalpv dlsnsgirsh
      601 gsgsfhgasa fdpccpvsss raaifghqaa aaapsqplss idgygssmva qpqpqpppqp
      661 slsscrhymp ppyasltrpl hhqasacphs hgnpppqtqp ppqvdyviph pvhafhsqis
      721 shatshpvap pppthlasta apipqhlppt hqpishhipa tappaqrlhp hevmqrmevq
      781 rrrmmqhptg lfvfcvsrra herppphphr mhpnyghghh ihvpqtmssh prqapersaw
      841 elgieagvta atytpgalhp hlahyhappr lhhlqlgalp lmvpdmagyp hiryissgld
      901 gtsfrgpfrg nfeelihlee rlgnvnrgas qgtierctyp hkykkvttdw fsqrklhckq
      961 dgeegteedt eekcticlsi leegedvrrl pcmhlfhqvc vdqwlitnkk cpicrvdiea
     1021 qlpses
//
LOCUS       XP_047288669            1026 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase Arkadia isoform X9 [Homo sapiens].
ACCESSION   XP_047288669
VERSION     XP_047288669.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432713.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1026
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1026
                     /product="E3 ubiquitin-protein ligase Arkadia isoform X9"
                     /calculated_mol_wt=112210
     Region          41..315
                     /region_name="RNF111_N"
                     /note="E3 ubiquitin-protein ligase Arkadia N-terminus;
                     pfam15303"
                     /db_xref="CDD:464629"
     Region          422..>553
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          962..1022
                     /region_name="RING-H2_RNF111"
                     /note="RING finger, H2 subclass, found in RING finger
                     protein 111 (RNF111) and similar proteins; cd16681"
                     /db_xref="CDD:438343"
     CDS             1..1026
                     /gene="RNF111"
                     /gene_synonym="ARK; hRNF111"
                     /coded_by="XM_047432713.1:563..3643"
                     /db_xref="GeneID:54778"
                     /db_xref="HGNC:HGNC:17384"
                     /db_xref="MIM:605840"
ORIGIN      
        1 mhvfslidgs sglavlrlsl kfpmsqwtpe ynelytlkvd mkseipsdap ktqeslkgil
       61 lhpepigaak sfpagvemin skvgnefshl cddsqkqeke mngnqqeqek slvvrkkrks
      121 qqagpsyvqn cvkenqgilg lrqhlgtpsd edndssfsdc lsspssslhf gdsdtvtsde
      181 dkevsvrhsq tilnaksrsh sarshkwprt etesvsgllm krpclhgssl rrlpcrkrfv
      241 knnssqrtqk qkerilmqrk krevlarrky allpssssss endlssesss ssstegeedl
      301 fvsasenhqn npavpsgsid edvvvieass tpqvtaneei nvtstdseve ivtvgesyrs
      361 rstlghsrsh wsqgssshas rpqeprnrsr istviqplrq naaevvdltv dedeptvvpt
      421 tsarmesqat sasinnsnps tseqasdtas avtssqpstv setsatltsn sttgtsigdd
      481 srrttssavt etgppamprl psccpqhspc ggssqnhhal ghphtscfqq hghhfqhhhh
      541 hhhtphpavp vspsfsdpac pverppqvqa pcgansssgt syheqqalpv dlsnsgirsh
      601 gsgsfhgasa fdpccpvsss raaifghqaa aaapsqplss idgygssmva qpqpqpppqp
      661 slsscrhymp ppyasltrpl hhqasacphs hgnpppqtqp ppqvdyviph pvhafhsqis
      721 shatshpvap pppthlasta apipqhlppt hqpishhipa tappaqrlhp hevmqrmevq
      781 rrrmmqhptg lfvfcvsrra herppphphr mhpnyghghh ihvpqtmssh prqapersaw
      841 elgieagvta atytpgalhp hlahyhappr lhhlqlgalp lmvpdmagyp hiryissgld
      901 gtsfrgpfrg nfeelihlee rlgnvnrgas qgtierctyp hkykkvttdw fsqrklhckq
      961 dgeegteedt eekcticlsi leegedvrrl pcmhlfhqvc vdqwlitnkk cpicrvdiea
     1021 qlpses
//
LOCUS       XP_047288670            1025 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase Arkadia isoform X10 [Homo sapiens].
ACCESSION   XP_047288670
VERSION     XP_047288670.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432714.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1025
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1025
                     /product="E3 ubiquitin-protein ligase Arkadia isoform X10"
                     /calculated_mol_wt=112082
     Region          41..315
                     /region_name="RNF111_N"
                     /note="E3 ubiquitin-protein ligase Arkadia N-terminus;
                     pfam15303"
                     /db_xref="CDD:464629"
     Region          422..>553
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          961..1021
                     /region_name="RING-H2_RNF111"
                     /note="RING finger, H2 subclass, found in RING finger
                     protein 111 (RNF111) and similar proteins; cd16681"
                     /db_xref="CDD:438343"
     CDS             1..1025
                     /gene="RNF111"
                     /gene_synonym="ARK; hRNF111"
                     /coded_by="XM_047432714.1:530..3607"
                     /db_xref="GeneID:54778"
                     /db_xref="HGNC:HGNC:17384"
                     /db_xref="MIM:605840"
ORIGIN      
        1 mhvfslidgs sglavlrlsl kfpmsqwtpe ynelytlkvd mkseipsdap ktqeslkgil
       61 lhpepigaak sfpagvemin skvgnefshl cddsqkqeke mngnqqeqek slvvrkkrks
      121 qqagpsyvqn cvkenqgilg lrqhlgtpsd edndssfsdc lsspssslhf gdsdtvtsde
      181 dkevsvrhsq tilnaksrsh sarshkwprt etesvsgllm krpclhgssl rrlpcrkrfv
      241 knnssqrtqk qkerilmqrk krevlarrky allpssssss endlssesss ssstegeedl
      301 fvsasenhqn npavpsgsid edvvvieass tpqvtaneei nvtstdseve ivtvgesyrs
      361 rstlghsrsh wsqgssshas rpqeprnrsr istviqplrq naaevvdltv dedeptvvpt
      421 tsarmesqat sasinnsnps tseqasdtas avtssqpstv setsatltsn sttgtsigdd
      481 srrttssavt etgppamprl psccpqhspc ggssqnhhal ghphtscfqq hghhfqhhhh
      541 hhhtphpavp vspsfsdpac pverppqvqa pcgansssgt syheqalpvd lsnsgirshg
      601 sgsfhgasaf dpccpvsssr aaifghqaaa aapsqplssi dgygssmvaq pqpqpppqps
      661 lsscrhympp pyasltrplh hqasacphsh gnpppqtqpp pqvdyviphp vhafhsqiss
      721 hatshpvapp ppthlastaa pipqhlppth qpishhipat appaqrlhph evmqrmevqr
      781 rrmmqhptgl fvfcvsrrah erppphphrm hpnyghghhi hvpqtmsshp rqapersawe
      841 lgieagvtaa tytpgalhph lahyhapprl hhlqlgalpl mvpdmagyph iryissgldg
      901 tsfrgpfrgn feelihleer lgnvnrgasq gtierctyph kykkvttdwf sqrklhckqd
      961 geegteedte ekcticlsil eegedvrrlp cmhlfhqvcv dqwlitnkkc picrvdieaq
     1021 lpses
//
LOCUS       XP_047288671            1018 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase Arkadia isoform X11 [Homo sapiens].
ACCESSION   XP_047288671
VERSION     XP_047288671.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432715.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1018
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1018
                     /product="E3 ubiquitin-protein ligase Arkadia isoform X11"
                     /calculated_mol_wt=111245
     Region          41..315
                     /region_name="RNF111_N"
                     /note="E3 ubiquitin-protein ligase Arkadia N-terminus;
                     pfam15303"
                     /db_xref="CDD:464629"
     Region          422..>553
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          954..1014
                     /region_name="RING-H2_RNF111"
                     /note="RING finger, H2 subclass, found in RING finger
                     protein 111 (RNF111) and similar proteins; cd16681"
                     /db_xref="CDD:438343"
     CDS             1..1018
                     /gene="RNF111"
                     /gene_synonym="ARK; hRNF111"
                     /coded_by="XM_047432715.1:530..3586"
                     /db_xref="GeneID:54778"
                     /db_xref="HGNC:HGNC:17384"
                     /db_xref="MIM:605840"
ORIGIN      
        1 mhvfslidgs sglavlrlsl kfpmsqwtpe ynelytlkvd mkseipsdap ktqeslkgil
       61 lhpepigaak sfpagvemin skvgnefshl cddsqkqeke mngnqqeqek slvvrkkrks
      121 qqagpsyvqn cvkenqgilg lrqhlgtpsd edndssfsdc lsspssslhf gdsdtvtsde
      181 dkevsvrhsq tilnaksrsh sarshkwprt etesvsgllm krpclhgssl rrlpcrkrfv
      241 knnssqrtqk qkerilmqrk krevlarrky allpssssss endlssesss ssstegeedl
      301 fvsasenhqn npavpsgsid edvvvieass tpqvtaneei nvtstdseve ivtvgesyrs
      361 rstlghsrsh wsqgssshas rpqeprnrsr istviqplrq naaevvdltv dedeptvvpt
      421 tsarmesqat sasinnsnps tseqasdtas avtssqpstv setsatltsn sttgtsigdd
      481 srrttssavt etgppamprl psccpqhspc ggssqnhhal ghphtscfqq hghhfqhhhh
      541 hhhtphpavp vspsfsdpac pverppqvqa pcgansssgt syheqqalpv dlsnsgirsh
      601 gsgsfhgasa fdpccpvsss raaifghqaa aaapsqplss idgygssmva qpqpqpppqp
      661 slsscrhymp ppyasltrpl hhqasacphs hgnpppqtqp ppqvdyviph pvhafhsqis
      721 shatshpvap pppthlasta apipqhlppt hqpishhipa tappaqrlhp hevmqrmevq
      781 rrrmmqhptg lfvfcvsrra herppphphr mhpnyghghh ihvpqtmssh prqapersaw
      841 elgieagvta atytpgalhp hlahyhappr lhhlqlgalp lmvpdmagyp hiryissgld
      901 gtsfrgpfrg nfeelihlee rlgnvnrgas qgtierctyp hkykkrklhc kqdgeegtee
      961 dteekcticl sileegedvr rlpcmhlfhq vcvdqwlitn kkcpicrvdi eaqlpses
//
LOCUS       XP_047288672            1017 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase Arkadia isoform X12 [Homo sapiens].
ACCESSION   XP_047288672
VERSION     XP_047288672.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432716.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1017
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1017
                     /product="E3 ubiquitin-protein ligase Arkadia isoform X12"
                     /calculated_mol_wt=111201
     Region          41..315
                     /region_name="RNF111_N"
                     /note="E3 ubiquitin-protein ligase Arkadia N-terminus;
                     pfam15303"
                     /db_xref="CDD:464629"
     Region          422..>553
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          953..1013
                     /region_name="RING-H2_RNF111"
                     /note="RING finger, H2 subclass, found in RING finger
                     protein 111 (RNF111) and similar proteins; cd16681"
                     /db_xref="CDD:438343"
     CDS             1..1017
                     /gene="RNF111"
                     /gene_synonym="ARK; hRNF111"
                     /coded_by="XM_047432716.1:530..3583"
                     /db_xref="GeneID:54778"
                     /db_xref="HGNC:HGNC:17384"
                     /db_xref="MIM:605840"
ORIGIN      
        1 mhvfslidgs sglavlrlsl kfpmsqwtpe ynelytlkvd mkseipsdap ktqeslkgil
       61 lhpepigaak sfpagvemin skvgnefshl cddsqkqeke mngnqqeqek slvvrkkrks
      121 qqagpsyvqn cvkenqgilg lrqhlgtpsd edndssfsdc lsspssslhf gdsdtvtsde
      181 dkevsvrhsq tilnaksrsh sarshkwprt etesvsgllm krpclhgssl rrlpcrkrfv
      241 knnssqrtqk qkerilmqrk krevlarrky allpssssss endlssesss ssstegeedl
      301 fvsasenhqn npavpsgsid edvvvieass tpqvtaneei nvtstdseve ivtvgesyrs
      361 rstlghsrsh wsqgssshas rpqeprnrsr istviqplrq naaevvdltv dedeptvvpt
      421 tsarmesqat sasinnsnps tseqasdtas avtssqpstv setsatltsn sttgtsigdd
      481 srrttssavt etgppamprl psccpqhspc ggssqnhhal ghphtscfqq hghhfqhhhh
      541 hhhtphpavp vspsfsdpac pverppqvqa pcgansssgt syheqqalpv dlsnsgirsh
      601 gsgsfhgasa fdpccpvsss raaifghqaa aaapsqplss idgygssmva qpqpqpppqp
      661 slsscrhymp ppyasltrpl hhqasacphs hgnpppqtqp ppqvdyviph pvhafhsqis
      721 shatshpvap pppthlasta apipqhlppt hqpishhipa tappaqrlhp hevmqrmevq
      781 rrrmmqhptr aherppphph rmhpnyghgh hihvpqtmss hprqapersa welgieagvt
      841 aatytpgalh phlahyhapp rlhhlqlgal plmvpdmagy phiryissgl dgtsfrgpfr
      901 gnfeelihle erlgnvnrga sqgtiercty phkykkvttd wfsqrklhck qdgeegteed
      961 teekcticls ileegedvrr lpcmhlfhqv cvdqwlitnk kcpicrvdie aqlpses
//
LOCUS       XP_047288673            1017 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase Arkadia isoform X12 [Homo sapiens].
ACCESSION   XP_047288673
VERSION     XP_047288673.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432717.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1017
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1017
                     /product="E3 ubiquitin-protein ligase Arkadia isoform X12"
                     /calculated_mol_wt=111201
     Region          41..315
                     /region_name="RNF111_N"
                     /note="E3 ubiquitin-protein ligase Arkadia N-terminus;
                     pfam15303"
                     /db_xref="CDD:464629"
     Region          422..>553
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          953..1013
                     /region_name="RING-H2_RNF111"
                     /note="RING finger, H2 subclass, found in RING finger
                     protein 111 (RNF111) and similar proteins; cd16681"
                     /db_xref="CDD:438343"
     CDS             1..1017
                     /gene="RNF111"
                     /gene_synonym="ARK; hRNF111"
                     /coded_by="XM_047432717.1:563..3616"
                     /db_xref="GeneID:54778"
                     /db_xref="HGNC:HGNC:17384"
                     /db_xref="MIM:605840"
ORIGIN      
        1 mhvfslidgs sglavlrlsl kfpmsqwtpe ynelytlkvd mkseipsdap ktqeslkgil
       61 lhpepigaak sfpagvemin skvgnefshl cddsqkqeke mngnqqeqek slvvrkkrks
      121 qqagpsyvqn cvkenqgilg lrqhlgtpsd edndssfsdc lsspssslhf gdsdtvtsde
      181 dkevsvrhsq tilnaksrsh sarshkwprt etesvsgllm krpclhgssl rrlpcrkrfv
      241 knnssqrtqk qkerilmqrk krevlarrky allpssssss endlssesss ssstegeedl
      301 fvsasenhqn npavpsgsid edvvvieass tpqvtaneei nvtstdseve ivtvgesyrs
      361 rstlghsrsh wsqgssshas rpqeprnrsr istviqplrq naaevvdltv dedeptvvpt
      421 tsarmesqat sasinnsnps tseqasdtas avtssqpstv setsatltsn sttgtsigdd
      481 srrttssavt etgppamprl psccpqhspc ggssqnhhal ghphtscfqq hghhfqhhhh
      541 hhhtphpavp vspsfsdpac pverppqvqa pcgansssgt syheqqalpv dlsnsgirsh
      601 gsgsfhgasa fdpccpvsss raaifghqaa aaapsqplss idgygssmva qpqpqpppqp
      661 slsscrhymp ppyasltrpl hhqasacphs hgnpppqtqp ppqvdyviph pvhafhsqis
      721 shatshpvap pppthlasta apipqhlppt hqpishhipa tappaqrlhp hevmqrmevq
      781 rrrmmqhptr aherppphph rmhpnyghgh hihvpqtmss hprqapersa welgieagvt
      841 aatytpgalh phlahyhapp rlhhlqlgal plmvpdmagy phiryissgl dgtsfrgpfr
      901 gnfeelihle erlgnvnrga sqgtiercty phkykkvttd wfsqrklhck qdgeegteed
      961 teekcticls ileegedvrr lpcmhlfhqv cvdqwlitnk kcpicrvdie aqlpses
//
LOCUS       XP_047288674            1017 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase Arkadia isoform X13 [Homo sapiens].
ACCESSION   XP_047288674
VERSION     XP_047288674.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432718.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1017
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1017
                     /product="E3 ubiquitin-protein ligase Arkadia isoform X13"
                     /calculated_mol_wt=111117
     Region          41..315
                     /region_name="RNF111_N"
                     /note="E3 ubiquitin-protein ligase Arkadia N-terminus;
                     pfam15303"
                     /db_xref="CDD:464629"
     Region          422..>553
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          953..1013
                     /region_name="RING-H2_RNF111"
                     /note="RING finger, H2 subclass, found in RING finger
                     protein 111 (RNF111) and similar proteins; cd16681"
                     /db_xref="CDD:438343"
     CDS             1..1017
                     /gene="RNF111"
                     /gene_synonym="ARK; hRNF111"
                     /coded_by="XM_047432718.1:530..3583"
                     /db_xref="GeneID:54778"
                     /db_xref="HGNC:HGNC:17384"
                     /db_xref="MIM:605840"
ORIGIN      
        1 mhvfslidgs sglavlrlsl kfpmsqwtpe ynelytlkvd mkseipsdap ktqeslkgil
       61 lhpepigaak sfpagvemin skvgnefshl cddsqkqeke mngnqqeqek slvvrkkrks
      121 qqagpsyvqn cvkenqgilg lrqhlgtpsd edndssfsdc lsspssslhf gdsdtvtsde
      181 dkevsvrhsq tilnaksrsh sarshkwprt etesvsgllm krpclhgssl rrlpcrkrfv
      241 knnssqrtqk qkerilmqrk krevlarrky allpssssss endlssesss ssstegeedl
      301 fvsasenhqn npavpsgsid edvvvieass tpqvtaneei nvtstdseve ivtvgesyrs
      361 rstlghsrsh wsqgssshas rpqeprnrsr istviqplrq naaevvdltv dedeptvvpt
      421 tsarmesqat sasinnsnps tseqasdtas avtssqpstv setsatltsn sttgtsigdd
      481 srrttssavt etgppamprl psccpqhspc ggssqnhhal ghphtscfqq hghhfqhhhh
      541 hhhtphpavp vspsfsdpac pverppqvqa pcgansssgt syheqalpvd lsnsgirshg
      601 sgsfhgasaf dpccpvsssr aaifghqaaa aapsqplssi dgygssmvaq pqpqpppqps
      661 lsscrhympp pyasltrplh hqasacphsh gnpppqtqpp pqvdyviphp vhafhsqiss
      721 hatshpvapp ppthlastaa pipqhlppth qpishhipat appaqrlhph evmqrmevqr
      781 rrmmqhptgl fvfcvsrrah erppphphrm hpnyghghhi hvpqtmsshp rqapersawe
      841 lgieagvtaa tytpgalhph lahyhapprl hhlqlgalpl mvpdmagyph iryissgldg
      901 tsfrgpfrgn feelihleer lgnvnrgasq gtierctyph kykkrklhck qdgeegteed
      961 teekcticls ileegedvrr lpcmhlfhqv cvdqwlitnk kcpicrvdie aqlpses
//
LOCUS       XP_047288675            1016 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase Arkadia isoform X14 [Homo sapiens].
ACCESSION   XP_047288675
VERSION     XP_047288675.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432719.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1016
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1016
                     /product="E3 ubiquitin-protein ligase Arkadia isoform X14"
                     /calculated_mol_wt=111073
     Region          41..315
                     /region_name="RNF111_N"
                     /note="E3 ubiquitin-protein ligase Arkadia N-terminus;
                     pfam15303"
                     /db_xref="CDD:464629"
     Region          422..>553
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          952..1012
                     /region_name="RING-H2_RNF111"
                     /note="RING finger, H2 subclass, found in RING finger
                     protein 111 (RNF111) and similar proteins; cd16681"
                     /db_xref="CDD:438343"
     CDS             1..1016
                     /gene="RNF111"
                     /gene_synonym="ARK; hRNF111"
                     /coded_by="XM_047432719.1:530..3580"
                     /db_xref="GeneID:54778"
                     /db_xref="HGNC:HGNC:17384"
                     /db_xref="MIM:605840"
ORIGIN      
        1 mhvfslidgs sglavlrlsl kfpmsqwtpe ynelytlkvd mkseipsdap ktqeslkgil
       61 lhpepigaak sfpagvemin skvgnefshl cddsqkqeke mngnqqeqek slvvrkkrks
      121 qqagpsyvqn cvkenqgilg lrqhlgtpsd edndssfsdc lsspssslhf gdsdtvtsde
      181 dkevsvrhsq tilnaksrsh sarshkwprt etesvsgllm krpclhgssl rrlpcrkrfv
      241 knnssqrtqk qkerilmqrk krevlarrky allpssssss endlssesss ssstegeedl
      301 fvsasenhqn npavpsgsid edvvvieass tpqvtaneei nvtstdseve ivtvgesyrs
      361 rstlghsrsh wsqgssshas rpqeprnrsr istviqplrq naaevvdltv dedeptvvpt
      421 tsarmesqat sasinnsnps tseqasdtas avtssqpstv setsatltsn sttgtsigdd
      481 srrttssavt etgppamprl psccpqhspc ggssqnhhal ghphtscfqq hghhfqhhhh
      541 hhhtphpavp vspsfsdpac pverppqvqa pcgansssgt syheqalpvd lsnsgirshg
      601 sgsfhgasaf dpccpvsssr aaifghqaaa aapsqplssi dgygssmvaq pqpqpppqps
      661 lsscrhympp pyasltrplh hqasacphsh gnpppqtqpp pqvdyviphp vhafhsqiss
      721 hatshpvapp ppthlastaa pipqhlppth qpishhipat appaqrlhph evmqrmevqr
      781 rrmmqhptra herppphphr mhpnyghghh ihvpqtmssh prqapersaw elgieagvta
      841 atytpgalhp hlahyhappr lhhlqlgalp lmvpdmagyp hiryissgld gtsfrgpfrg
      901 nfeelihlee rlgnvnrgas qgtierctyp hkykkvttdw fsqrklhckq dgeegteedt
      961 eekcticlsi leegedvrrl pcmhlfhqvc vdqwlitnkk cpicrvdiea qlpses
//
LOCUS       XP_047288676            1016 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase Arkadia isoform X14 [Homo sapiens].
ACCESSION   XP_047288676
VERSION     XP_047288676.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432720.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1016
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1016
                     /product="E3 ubiquitin-protein ligase Arkadia isoform X14"
                     /calculated_mol_wt=111073
     Region          41..315
                     /region_name="RNF111_N"
                     /note="E3 ubiquitin-protein ligase Arkadia N-terminus;
                     pfam15303"
                     /db_xref="CDD:464629"
     Region          422..>553
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          952..1012
                     /region_name="RING-H2_RNF111"
                     /note="RING finger, H2 subclass, found in RING finger
                     protein 111 (RNF111) and similar proteins; cd16681"
                     /db_xref="CDD:438343"
     CDS             1..1016
                     /gene="RNF111"
                     /gene_synonym="ARK; hRNF111"
                     /coded_by="XM_047432720.1:563..3613"
                     /db_xref="GeneID:54778"
                     /db_xref="HGNC:HGNC:17384"
                     /db_xref="MIM:605840"
ORIGIN      
        1 mhvfslidgs sglavlrlsl kfpmsqwtpe ynelytlkvd mkseipsdap ktqeslkgil
       61 lhpepigaak sfpagvemin skvgnefshl cddsqkqeke mngnqqeqek slvvrkkrks
      121 qqagpsyvqn cvkenqgilg lrqhlgtpsd edndssfsdc lsspssslhf gdsdtvtsde
      181 dkevsvrhsq tilnaksrsh sarshkwprt etesvsgllm krpclhgssl rrlpcrkrfv
      241 knnssqrtqk qkerilmqrk krevlarrky allpssssss endlssesss ssstegeedl
      301 fvsasenhqn npavpsgsid edvvvieass tpqvtaneei nvtstdseve ivtvgesyrs
      361 rstlghsrsh wsqgssshas rpqeprnrsr istviqplrq naaevvdltv dedeptvvpt
      421 tsarmesqat sasinnsnps tseqasdtas avtssqpstv setsatltsn sttgtsigdd
      481 srrttssavt etgppamprl psccpqhspc ggssqnhhal ghphtscfqq hghhfqhhhh
      541 hhhtphpavp vspsfsdpac pverppqvqa pcgansssgt syheqalpvd lsnsgirshg
      601 sgsfhgasaf dpccpvsssr aaifghqaaa aapsqplssi dgygssmvaq pqpqpppqps
      661 lsscrhympp pyasltrplh hqasacphsh gnpppqtqpp pqvdyviphp vhafhsqiss
      721 hatshpvapp ppthlastaa pipqhlppth qpishhipat appaqrlhph evmqrmevqr
      781 rrmmqhptra herppphphr mhpnyghghh ihvpqtmssh prqapersaw elgieagvta
      841 atytpgalhp hlahyhappr lhhlqlgalp lmvpdmagyp hiryissgld gtsfrgpfrg
      901 nfeelihlee rlgnvnrgas qgtierctyp hkykkvttdw fsqrklhckq dgeegteedt
      961 eekcticlsi leegedvrrl pcmhlfhqvc vdqwlitnkk cpicrvdiea qlpses
//
LOCUS       XP_016877825            1009 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase Arkadia isoform X15 [Homo sapiens].
ACCESSION   XP_016877825
VERSION     XP_016877825.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022336.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1009
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1009
                     /product="E3 ubiquitin-protein ligase Arkadia isoform X15"
                     /calculated_mol_wt=110236
     Region          41..315
                     /region_name="RNF111_N"
                     /note="E3 ubiquitin-protein ligase Arkadia N-terminus;
                     pfam15303"
                     /db_xref="CDD:464629"
     Region          422..>553
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          945..1005
                     /region_name="RING-H2_RNF111"
                     /note="RING finger, H2 subclass, found in RING finger
                     protein 111 (RNF111) and similar proteins; cd16681"
                     /db_xref="CDD:438343"
     CDS             1..1009
                     /gene="RNF111"
                     /gene_synonym="ARK; hRNF111"
                     /coded_by="XM_017022336.2:530..3559"
                     /db_xref="GeneID:54778"
                     /db_xref="HGNC:HGNC:17384"
                     /db_xref="MIM:605840"
ORIGIN      
        1 mhvfslidgs sglavlrlsl kfpmsqwtpe ynelytlkvd mkseipsdap ktqeslkgil
       61 lhpepigaak sfpagvemin skvgnefshl cddsqkqeke mngnqqeqek slvvrkkrks
      121 qqagpsyvqn cvkenqgilg lrqhlgtpsd edndssfsdc lsspssslhf gdsdtvtsde
      181 dkevsvrhsq tilnaksrsh sarshkwprt etesvsgllm krpclhgssl rrlpcrkrfv
      241 knnssqrtqk qkerilmqrk krevlarrky allpssssss endlssesss ssstegeedl
      301 fvsasenhqn npavpsgsid edvvvieass tpqvtaneei nvtstdseve ivtvgesyrs
      361 rstlghsrsh wsqgssshas rpqeprnrsr istviqplrq naaevvdltv dedeptvvpt
      421 tsarmesqat sasinnsnps tseqasdtas avtssqpstv setsatltsn sttgtsigdd
      481 srrttssavt etgppamprl psccpqhspc ggssqnhhal ghphtscfqq hghhfqhhhh
      541 hhhtphpavp vspsfsdpac pverppqvqa pcgansssgt syheqqalpv dlsnsgirsh
      601 gsgsfhgasa fdpccpvsss raaifghqaa aaapsqplss idgygssmva qpqpqpppqp
      661 slsscrhymp ppyasltrpl hhqasacphs hgnpppqtqp ppqvdyviph pvhafhsqis
      721 shatshpvap pppthlasta apipqhlppt hqpishhipa tappaqrlhp hevmqrmevq
      781 rrrmmqhptr aherppphph rmhpnyghgh hihvpqtmss hprqapersa welgieagvt
      841 aatytpgalh phlahyhapp rlhhlqlgal plmvpdmagy phiryissgl dgtsfrgpfr
      901 gnfeelihle erlgnvnrga sqgtiercty phkykkrklh ckqdgeegte edteekctic
      961 lsileegedv rrlpcmhlfh qvcvdqwlit nkkcpicrvd ieaqlpses
//
LOCUS       XP_047288677            1009 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase Arkadia isoform X15 [Homo sapiens].
ACCESSION   XP_047288677
VERSION     XP_047288677.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432721.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1009
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1009
                     /product="E3 ubiquitin-protein ligase Arkadia isoform X15"
                     /calculated_mol_wt=110236
     Region          41..315
                     /region_name="RNF111_N"
                     /note="E3 ubiquitin-protein ligase Arkadia N-terminus;
                     pfam15303"
                     /db_xref="CDD:464629"
     Region          422..>553
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          945..1005
                     /region_name="RING-H2_RNF111"
                     /note="RING finger, H2 subclass, found in RING finger
                     protein 111 (RNF111) and similar proteins; cd16681"
                     /db_xref="CDD:438343"
     CDS             1..1009
                     /gene="RNF111"
                     /gene_synonym="ARK; hRNF111"
                     /coded_by="XM_047432721.1:563..3592"
                     /db_xref="GeneID:54778"
                     /db_xref="HGNC:HGNC:17384"
                     /db_xref="MIM:605840"
ORIGIN      
        1 mhvfslidgs sglavlrlsl kfpmsqwtpe ynelytlkvd mkseipsdap ktqeslkgil
       61 lhpepigaak sfpagvemin skvgnefshl cddsqkqeke mngnqqeqek slvvrkkrks
      121 qqagpsyvqn cvkenqgilg lrqhlgtpsd edndssfsdc lsspssslhf gdsdtvtsde
      181 dkevsvrhsq tilnaksrsh sarshkwprt etesvsgllm krpclhgssl rrlpcrkrfv
      241 knnssqrtqk qkerilmqrk krevlarrky allpssssss endlssesss ssstegeedl
      301 fvsasenhqn npavpsgsid edvvvieass tpqvtaneei nvtstdseve ivtvgesyrs
      361 rstlghsrsh wsqgssshas rpqeprnrsr istviqplrq naaevvdltv dedeptvvpt
      421 tsarmesqat sasinnsnps tseqasdtas avtssqpstv setsatltsn sttgtsigdd
      481 srrttssavt etgppamprl psccpqhspc ggssqnhhal ghphtscfqq hghhfqhhhh
      541 hhhtphpavp vspsfsdpac pverppqvqa pcgansssgt syheqqalpv dlsnsgirsh
      601 gsgsfhgasa fdpccpvsss raaifghqaa aaapsqplss idgygssmva qpqpqpppqp
      661 slsscrhymp ppyasltrpl hhqasacphs hgnpppqtqp ppqvdyviph pvhafhsqis
      721 shatshpvap pppthlasta apipqhlppt hqpishhipa tappaqrlhp hevmqrmevq
      781 rrrmmqhptr aherppphph rmhpnyghgh hihvpqtmss hprqapersa welgieagvt
      841 aatytpgalh phlahyhapp rlhhlqlgal plmvpdmagy phiryissgl dgtsfrgpfr
      901 gnfeelihle erlgnvnrga sqgtiercty phkykkrklh ckqdgeegte edteekctic
      961 lsileegedv rrlpcmhlfh qvcvdqwlit nkkcpicrvd ieaqlpses
//
LOCUS       XP_047288678            1008 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase Arkadia isoform X16 [Homo sapiens].
ACCESSION   XP_047288678
VERSION     XP_047288678.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432722.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1008
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1008
                     /product="E3 ubiquitin-protein ligase Arkadia isoform X16"
                     /calculated_mol_wt=110108
     Region          41..315
                     /region_name="RNF111_N"
                     /note="E3 ubiquitin-protein ligase Arkadia N-terminus;
                     pfam15303"
                     /db_xref="CDD:464629"
     Region          422..>553
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          944..1004
                     /region_name="RING-H2_RNF111"
                     /note="RING finger, H2 subclass, found in RING finger
                     protein 111 (RNF111) and similar proteins; cd16681"
                     /db_xref="CDD:438343"
     CDS             1..1008
                     /gene="RNF111"
                     /gene_synonym="ARK; hRNF111"
                     /coded_by="XM_047432722.1:530..3556"
                     /db_xref="GeneID:54778"
                     /db_xref="HGNC:HGNC:17384"
                     /db_xref="MIM:605840"
ORIGIN      
        1 mhvfslidgs sglavlrlsl kfpmsqwtpe ynelytlkvd mkseipsdap ktqeslkgil
       61 lhpepigaak sfpagvemin skvgnefshl cddsqkqeke mngnqqeqek slvvrkkrks
      121 qqagpsyvqn cvkenqgilg lrqhlgtpsd edndssfsdc lsspssslhf gdsdtvtsde
      181 dkevsvrhsq tilnaksrsh sarshkwprt etesvsgllm krpclhgssl rrlpcrkrfv
      241 knnssqrtqk qkerilmqrk krevlarrky allpssssss endlssesss ssstegeedl
      301 fvsasenhqn npavpsgsid edvvvieass tpqvtaneei nvtstdseve ivtvgesyrs
      361 rstlghsrsh wsqgssshas rpqeprnrsr istviqplrq naaevvdltv dedeptvvpt
      421 tsarmesqat sasinnsnps tseqasdtas avtssqpstv setsatltsn sttgtsigdd
      481 srrttssavt etgppamprl psccpqhspc ggssqnhhal ghphtscfqq hghhfqhhhh
      541 hhhtphpavp vspsfsdpac pverppqvqa pcgansssgt syheqalpvd lsnsgirshg
      601 sgsfhgasaf dpccpvsssr aaifghqaaa aapsqplssi dgygssmvaq pqpqpppqps
      661 lsscrhympp pyasltrplh hqasacphsh gnpppqtqpp pqvdyviphp vhafhsqiss
      721 hatshpvapp ppthlastaa pipqhlppth qpishhipat appaqrlhph evmqrmevqr
      781 rrmmqhptra herppphphr mhpnyghghh ihvpqtmssh prqapersaw elgieagvta
      841 atytpgalhp hlahyhappr lhhlqlgalp lmvpdmagyp hiryissgld gtsfrgpfrg
      901 nfeelihlee rlgnvnrgas qgtierctyp hkykkrklhc kqdgeegtee dteekcticl
      961 sileegedvr rlpcmhlfhq vcvdqwlitn kkcpicrvdi eaqlpses
//
LOCUS       XP_047288679            1008 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase Arkadia isoform X16 [Homo sapiens].
ACCESSION   XP_047288679
VERSION     XP_047288679.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432723.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1008
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1008
                     /product="E3 ubiquitin-protein ligase Arkadia isoform X16"
                     /calculated_mol_wt=110108
     Region          41..315
                     /region_name="RNF111_N"
                     /note="E3 ubiquitin-protein ligase Arkadia N-terminus;
                     pfam15303"
                     /db_xref="CDD:464629"
     Region          422..>553
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          944..1004
                     /region_name="RING-H2_RNF111"
                     /note="RING finger, H2 subclass, found in RING finger
                     protein 111 (RNF111) and similar proteins; cd16681"
                     /db_xref="CDD:438343"
     CDS             1..1008
                     /gene="RNF111"
                     /gene_synonym="ARK; hRNF111"
                     /coded_by="XM_047432723.1:563..3589"
                     /db_xref="GeneID:54778"
                     /db_xref="HGNC:HGNC:17384"
                     /db_xref="MIM:605840"
ORIGIN      
        1 mhvfslidgs sglavlrlsl kfpmsqwtpe ynelytlkvd mkseipsdap ktqeslkgil
       61 lhpepigaak sfpagvemin skvgnefshl cddsqkqeke mngnqqeqek slvvrkkrks
      121 qqagpsyvqn cvkenqgilg lrqhlgtpsd edndssfsdc lsspssslhf gdsdtvtsde
      181 dkevsvrhsq tilnaksrsh sarshkwprt etesvsgllm krpclhgssl rrlpcrkrfv
      241 knnssqrtqk qkerilmqrk krevlarrky allpssssss endlssesss ssstegeedl
      301 fvsasenhqn npavpsgsid edvvvieass tpqvtaneei nvtstdseve ivtvgesyrs
      361 rstlghsrsh wsqgssshas rpqeprnrsr istviqplrq naaevvdltv dedeptvvpt
      421 tsarmesqat sasinnsnps tseqasdtas avtssqpstv setsatltsn sttgtsigdd
      481 srrttssavt etgppamprl psccpqhspc ggssqnhhal ghphtscfqq hghhfqhhhh
      541 hhhtphpavp vspsfsdpac pverppqvqa pcgansssgt syheqalpvd lsnsgirshg
      601 sgsfhgasaf dpccpvsssr aaifghqaaa aapsqplssi dgygssmvaq pqpqpppqps
      661 lsscrhympp pyasltrplh hqasacphsh gnpppqtqpp pqvdyviphp vhafhsqiss
      721 hatshpvapp ppthlastaa pipqhlppth qpishhipat appaqrlhph evmqrmevqr
      781 rrmmqhptra herppphphr mhpnyghghh ihvpqtmssh prqapersaw elgieagvta
      841 atytpgalhp hlahyhappr lhhlqlgalp lmvpdmagyp hiryissgld gtsfrgpfrg
      901 nfeelihlee rlgnvnrgas qgtierctyp hkykkrklhc kqdgeegtee dteekcticl
      961 sileegedvr rlpcmhlfhq vcvdqwlitn kkcpicrvdi eaqlpses
//
LOCUS       XP_047288697            3059 aa            linear   PRI 05-AUG-2025
DEFINITION  intermembrane lipid transfer protein VPS13C isoform X1 [Homo
            sapiens].
ACCESSION   XP_047288697
VERSION     XP_047288697.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432741.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..3059
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..3059
                     /product="intermembrane lipid transfer protein VPS13C
                     isoform X1"
                     /calculated_mol_wt=344628
     Region          3..>1366
                     /region_name="MRS6"
                     /note="Vacuolar protein sorting-associated protein
                     [Intracellular trafficking and secretion]; COG5043"
                     /db_xref="CDD:227376"
     Region          1046..>2612
                     /region_name="MRS6"
                     /note="Vacuolar protein sorting-associated protein
                     [Intracellular trafficking and secretion]; COG5043"
                     /db_xref="CDD:227376"
     Region          2766..>2942
                     /region_name="SHR-BD"
                     /note="SHR-binding domain of vacuolar-sorting associated
                     protein 13; pfam06650"
                     /db_xref="CDD:461974"
     CDS             1..3059
                     /gene="VPS13C"
                     /gene_synonym="BLTP5C; PARK23"
                     /coded_by="XM_047432741.1:74..9253"
                     /db_xref="GeneID:54832"
                     /db_xref="HGNC:HGNC:23594"
                     /db_xref="MIM:608879"
ORIGIN      
        1 mvlesvvadl lnrflgdyve nlnksqlklg iwggnvaldn lqikenalse ldvpfkvkag
       61 qidkltlkip wknlygeavv atleglyllv vpgasikyda vkeekslqdv kqkelsriee
      121 alqkaaekgt hsgefiygle nfvykdikpg rkrkkhkkhf kkpfkgldrs kdkpkeakkd
      181 tfveklatqv iknvqvkitd ihikyeddvt dpkrplsfgv tlgelsllta nehwtpciln
      241 eadkiiykli rldslsaywn vncsmsyqrs reqildqlkn eiltsgnipp nyqyifqpis
      301 asaklymnpy aeselktpkl dcnieiqnia ieltkpqyls midllesvdy mvrnapyrky
      361 kpylplhtng rrwwkyaids vlevhirryt qmwswsnikk hrqllksyki ayknkltqsk
      421 vseeiqkeiq dlektldvfn iilarqqaqv evirsgqklr kksadtgekr ggwfsglwgk
      481 keskkkdees lipetiddlm tpeekdklft aigysesthn ltlpkqyvah imtlklvsts
      541 vtirenknip eilkiqiigl gtqvsqrpga qalkveakle hwyitglrqq divpslvasi
      601 gdttssllki kfetnpedsp adqtlivqsq pveviydakt vnavveffqs nkgldleqit
      661 satlmkleei kertatglth iietrkvldl rinlkpsylv vpqtgfhhek sdllildfgt
      721 fqlnskdqgl qkttnsslee imdkaydkfd veiknvqllf araeetwkkc rfqhpstmhi
      781 lqpmdihvel akamvekdir marfkvsggl plmhvrisdq kmkdvlylmn siplpqkssa
      841 qsperqvssi piisggtkgl lgtsllldtv esesddeyfd aedgepqtck smkgselkka
      901 aevpneelin lllkfeikev ileftkqqke edtilvfnvt qlgteatmrt fdltvvsylk
      961 kisldyheie gskrkplhli sssdkpgldl lkveyikadk ngpsfqtafg kteqtvkvaf
     1021 sslnlllqtq alvasinylt tiipsddqsi svakevqist ekqqknstlp kaivssrdsd
     1081 iidfrlfakl nafcvivcne knniaeikiq gldsslslqs rkqslfarle niivtdvdpk
     1141 tvhkkavsim gnevfrfnld lypdategdl ytdmskvdgv lslnvgciqi vylhkflmsl
     1201 lnflnnfqta keslsaataq aaeraatsvk dlaqrsfrvs inidlkapvi vipqssistn
     1261 avvvdlglir vhnqfslvsd edylnppvid rmdvqltklt lyrtviqpgi yhpdiqllhp
     1321 inleflvnrn laaswyhkvp vveikghlds mnvslnqedl nllfrilten lcegtedldk
     1381 vkprvqetge ikepleisis qdvhdskntl ttgveeirsv diinmllnfe ikevvvtlmk
     1441 ksekkgrplh elnvlqlgme akvktydmta kaylkkismq cfdftdskge plhiinssnv
     1501 tdepllkmll tkadsdgpef ktihdstkqr lkvsfasldl vlhleallsf mdflssaapf
     1561 sepsssekes elkplvgesr siavkavssn isqkdvfdlk itaelnafnv fvcdqkcnia
     1621 dikihgmdas isvkpkqtdv farlkdiivm nvdlqsihkk avsilgdevf rfqltlypda
     1681 tegeayadms kvdgklsfkv gciqivyvhk ffmsllnfln nfqtakeals tatvqaaera
     1741 assmkdlaqk sfrllmdinl kapviiipqs svspnaviad lglirvenkf slvpmehysl
     1801 ppvidkmnie ltqlklsrti lqaslpqndi eilkpvnmll siqrnlaaaw yvqipgmeik
     1861 gklkpmqval seddltvlmk illenlgeas sqpsptqsvq etvrvrkvdv ssvpdhlkeq
     1921 edwtdsklsm nqivslqfdf hfeslsiily nndinqesgv afhndsfqlg elrlhlmass
     1981 gkmfkdgsmn vsvklktctl ddlregiera tsrmidrknd qdnnssmidi sykqdkngsq
     2041 idavldklyv casveflmtv adffikavpq spenvaketq ilprqtatgk vkiekddsvr
     2101 pnmtlkamit dpevvfvasl tkadapalta sfqcnlslst skleqmmeas vrdlkvlacp
     2161 flrekrgkni ttvlqpcslf mekctwasgk qninimvkef iikispiiln tvltimaals
     2221 pktkedgskd tskemenlwg iksindyntw flgvdtatei tesfkgiehs lieencgvvv
     2281 esiqvtlecg lghrtvplll aeskfsgnik nwtslmaava dvtlqvhyyn eihavwepli
     2341 ervegkrqwn lrldvkknpv qdksllpgdd fipepqmaih issgntmnit isksclnvfn
     2401 nlakgfsegt astfdyslkd rapftvknav gvpikvkpnc nlrvmgfpek sdifdvdagq
     2461 nleleyasmv pssqgnlsil srqessfftl tivphgytev anipvarpgr rlynvrnpna
     2521 shsdsvlvqi dategnkvit lrsplqiknh fsiafiiykf vknvklleri giarpeeefh
     2581 vpldsyrcql fiqpagileh qykesttyis wkeelhrsre vrcmlqcpsv evsflplivn
     2641 tvalpdelsy icthgedwdv ayiihlypsl tlrnllpysl ryllegtaet helaegstad
     2701 vlhsrisgei melvlvkyqg knwnghfrir dtlpeffpvc fssdstevtt vdlsvhvrri
     2761 gsrmvlsvfs pywlinkttr vlqyrsedih vkhpadfrdi ilfsfkkkni ftknkvqlki
     2821 stsawsssfs ldtvgsygcv kcpannmeyl vgvsikmssf nlsrivtltp fctiankssl
     2881 elevgeiasd gsmptnkwny iasseclpfw peslsgklcv rvvgcegssk pffynrqdng
     2941 tllsledlng gilvdvntae hstvitfsdy hegsapalim nhtpwdilty kqsgspeemv
     3001 llprqarlfa wadptgtrkl twtyaanvge hdllkdqkkh femyawhpql sykdmttmk
//
LOCUS       XP_011520015            3059 aa            linear   PRI 05-AUG-2025
DEFINITION  intermembrane lipid transfer protein VPS13C isoform X1 [Homo
            sapiens].
ACCESSION   XP_011520015
VERSION     XP_011520015.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521713.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..3059
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..3059
                     /product="intermembrane lipid transfer protein VPS13C
                     isoform X1"
                     /calculated_mol_wt=344628
     Region          3..>1366
                     /region_name="MRS6"
                     /note="Vacuolar protein sorting-associated protein
                     [Intracellular trafficking and secretion]; COG5043"
                     /db_xref="CDD:227376"
     Region          1046..>2612
                     /region_name="MRS6"
                     /note="Vacuolar protein sorting-associated protein
                     [Intracellular trafficking and secretion]; COG5043"
                     /db_xref="CDD:227376"
     Region          2766..>2942
                     /region_name="SHR-BD"
                     /note="SHR-binding domain of vacuolar-sorting associated
                     protein 13; pfam06650"
                     /db_xref="CDD:461974"
     CDS             1..3059
                     /gene="VPS13C"
                     /gene_synonym="BLTP5C; PARK23"
                     /coded_by="XM_011521713.4:74..9253"
                     /db_xref="GeneID:54832"
                     /db_xref="HGNC:HGNC:23594"
                     /db_xref="MIM:608879"
ORIGIN      
        1 mvlesvvadl lnrflgdyve nlnksqlklg iwggnvaldn lqikenalse ldvpfkvkag
       61 qidkltlkip wknlygeavv atleglyllv vpgasikyda vkeekslqdv kqkelsriee
      121 alqkaaekgt hsgefiygle nfvykdikpg rkrkkhkkhf kkpfkgldrs kdkpkeakkd
      181 tfveklatqv iknvqvkitd ihikyeddvt dpkrplsfgv tlgelsllta nehwtpciln
      241 eadkiiykli rldslsaywn vncsmsyqrs reqildqlkn eiltsgnipp nyqyifqpis
      301 asaklymnpy aeselktpkl dcnieiqnia ieltkpqyls midllesvdy mvrnapyrky
      361 kpylplhtng rrwwkyaids vlevhirryt qmwswsnikk hrqllksyki ayknkltqsk
      421 vseeiqkeiq dlektldvfn iilarqqaqv evirsgqklr kksadtgekr ggwfsglwgk
      481 keskkkdees lipetiddlm tpeekdklft aigysesthn ltlpkqyvah imtlklvsts
      541 vtirenknip eilkiqiigl gtqvsqrpga qalkveakle hwyitglrqq divpslvasi
      601 gdttssllki kfetnpedsp adqtlivqsq pveviydakt vnavveffqs nkgldleqit
      661 satlmkleei kertatglth iietrkvldl rinlkpsylv vpqtgfhhek sdllildfgt
      721 fqlnskdqgl qkttnsslee imdkaydkfd veiknvqllf araeetwkkc rfqhpstmhi
      781 lqpmdihvel akamvekdir marfkvsggl plmhvrisdq kmkdvlylmn siplpqkssa
      841 qsperqvssi piisggtkgl lgtsllldtv esesddeyfd aedgepqtck smkgselkka
      901 aevpneelin lllkfeikev ileftkqqke edtilvfnvt qlgteatmrt fdltvvsylk
      961 kisldyheie gskrkplhli sssdkpgldl lkveyikadk ngpsfqtafg kteqtvkvaf
     1021 sslnlllqtq alvasinylt tiipsddqsi svakevqist ekqqknstlp kaivssrdsd
     1081 iidfrlfakl nafcvivcne knniaeikiq gldsslslqs rkqslfarle niivtdvdpk
     1141 tvhkkavsim gnevfrfnld lypdategdl ytdmskvdgv lslnvgciqi vylhkflmsl
     1201 lnflnnfqta keslsaataq aaeraatsvk dlaqrsfrvs inidlkapvi vipqssistn
     1261 avvvdlglir vhnqfslvsd edylnppvid rmdvqltklt lyrtviqpgi yhpdiqllhp
     1321 inleflvnrn laaswyhkvp vveikghlds mnvslnqedl nllfrilten lcegtedldk
     1381 vkprvqetge ikepleisis qdvhdskntl ttgveeirsv diinmllnfe ikevvvtlmk
     1441 ksekkgrplh elnvlqlgme akvktydmta kaylkkismq cfdftdskge plhiinssnv
     1501 tdepllkmll tkadsdgpef ktihdstkqr lkvsfasldl vlhleallsf mdflssaapf
     1561 sepsssekes elkplvgesr siavkavssn isqkdvfdlk itaelnafnv fvcdqkcnia
     1621 dikihgmdas isvkpkqtdv farlkdiivm nvdlqsihkk avsilgdevf rfqltlypda
     1681 tegeayadms kvdgklsfkv gciqivyvhk ffmsllnfln nfqtakeals tatvqaaera
     1741 assmkdlaqk sfrllmdinl kapviiipqs svspnaviad lglirvenkf slvpmehysl
     1801 ppvidkmnie ltqlklsrti lqaslpqndi eilkpvnmll siqrnlaaaw yvqipgmeik
     1861 gklkpmqval seddltvlmk illenlgeas sqpsptqsvq etvrvrkvdv ssvpdhlkeq
     1921 edwtdsklsm nqivslqfdf hfeslsiily nndinqesgv afhndsfqlg elrlhlmass
     1981 gkmfkdgsmn vsvklktctl ddlregiera tsrmidrknd qdnnssmidi sykqdkngsq
     2041 idavldklyv casveflmtv adffikavpq spenvaketq ilprqtatgk vkiekddsvr
     2101 pnmtlkamit dpevvfvasl tkadapalta sfqcnlslst skleqmmeas vrdlkvlacp
     2161 flrekrgkni ttvlqpcslf mekctwasgk qninimvkef iikispiiln tvltimaals
     2221 pktkedgskd tskemenlwg iksindyntw flgvdtatei tesfkgiehs lieencgvvv
     2281 esiqvtlecg lghrtvplll aeskfsgnik nwtslmaava dvtlqvhyyn eihavwepli
     2341 ervegkrqwn lrldvkknpv qdksllpgdd fipepqmaih issgntmnit isksclnvfn
     2401 nlakgfsegt astfdyslkd rapftvknav gvpikvkpnc nlrvmgfpek sdifdvdagq
     2461 nleleyasmv pssqgnlsil srqessfftl tivphgytev anipvarpgr rlynvrnpna
     2521 shsdsvlvqi dategnkvit lrsplqiknh fsiafiiykf vknvklleri giarpeeefh
     2581 vpldsyrcql fiqpagileh qykesttyis wkeelhrsre vrcmlqcpsv evsflplivn
     2641 tvalpdelsy icthgedwdv ayiihlypsl tlrnllpysl ryllegtaet helaegstad
     2701 vlhsrisgei melvlvkyqg knwnghfrir dtlpeffpvc fssdstevtt vdlsvhvrri
     2761 gsrmvlsvfs pywlinkttr vlqyrsedih vkhpadfrdi ilfsfkkkni ftknkvqlki
     2821 stsawsssfs ldtvgsygcv kcpannmeyl vgvsikmssf nlsrivtltp fctiankssl
     2881 elevgeiasd gsmptnkwny iasseclpfw peslsgklcv rvvgcegssk pffynrqdng
     2941 tllsledlng gilvdvntae hstvitfsdy hegsapalim nhtpwdilty kqsgspeemv
     3001 llprqarlfa wadptgtrkl twtyaanvge hdllkdqkkh femyawhpql sykdmttmk
//
LOCUS       XP_011520016            2566 aa            linear   PRI 05-AUG-2025
DEFINITION  intermembrane lipid transfer protein VPS13C isoform X2 [Homo
            sapiens].
ACCESSION   XP_011520016
VERSION     XP_011520016.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521714.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2566
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2566
                     /product="intermembrane lipid transfer protein VPS13C
                     isoform X2"
                     /calculated_mol_wt=288427
     Region          3..>1366
                     /region_name="MRS6"
                     /note="Vacuolar protein sorting-associated protein
                     [Intracellular trafficking and secretion]; COG5043"
                     /db_xref="CDD:227376"
     Region          182..413
                     /region_name="VPS13"
                     /note="Vacuolar sorting-associated protein 13, N-terminal;
                     pfam16908"
                     /db_xref="CDD:465309"
     Region          1046..>2341
                     /region_name="MRS6"
                     /note="Vacuolar protein sorting-associated protein
                     [Intracellular trafficking and secretion]; COG5043"
                     /db_xref="CDD:227376"
     CDS             1..2566
                     /gene="VPS13C"
                     /gene_synonym="BLTP5C; PARK23"
                     /coded_by="XM_011521714.3:74..7774"
                     /db_xref="GeneID:54832"
                     /db_xref="HGNC:HGNC:23594"
                     /db_xref="MIM:608879"
ORIGIN      
        1 mvlesvvadl lnrflgdyve nlnksqlklg iwggnvaldn lqikenalse ldvpfkvkag
       61 qidkltlkip wknlygeavv atleglyllv vpgasikyda vkeekslqdv kqkelsriee
      121 alqkaaekgt hsgefiygle nfvykdikpg rkrkkhkkhf kkpfkgldrs kdkpkeakkd
      181 tfveklatqv iknvqvkitd ihikyeddvt dpkrplsfgv tlgelsllta nehwtpciln
      241 eadkiiykli rldslsaywn vncsmsyqrs reqildqlkn eiltsgnipp nyqyifqpis
      301 asaklymnpy aeselktpkl dcnieiqnia ieltkpqyls midllesvdy mvrnapyrky
      361 kpylplhtng rrwwkyaids vlevhirryt qmwswsnikk hrqllksyki ayknkltqsk
      421 vseeiqkeiq dlektldvfn iilarqqaqv evirsgqklr kksadtgekr ggwfsglwgk
      481 keskkkdees lipetiddlm tpeekdklft aigysesthn ltlpkqyvah imtlklvsts
      541 vtirenknip eilkiqiigl gtqvsqrpga qalkveakle hwyitglrqq divpslvasi
      601 gdttssllki kfetnpedsp adqtlivqsq pveviydakt vnavveffqs nkgldleqit
      661 satlmkleei kertatglth iietrkvldl rinlkpsylv vpqtgfhhek sdllildfgt
      721 fqlnskdqgl qkttnsslee imdkaydkfd veiknvqllf araeetwkkc rfqhpstmhi
      781 lqpmdihvel akamvekdir marfkvsggl plmhvrisdq kmkdvlylmn siplpqkssa
      841 qsperqvssi piisggtkgl lgtsllldtv esesddeyfd aedgepqtck smkgselkka
      901 aevpneelin lllkfeikev ileftkqqke edtilvfnvt qlgteatmrt fdltvvsylk
      961 kisldyheie gskrkplhli sssdkpgldl lkveyikadk ngpsfqtafg kteqtvkvaf
     1021 sslnlllqtq alvasinylt tiipsddqsi svakevqist ekqqknstlp kaivssrdsd
     1081 iidfrlfakl nafcvivcne knniaeikiq gldsslslqs rkqslfarle niivtdvdpk
     1141 tvhkkavsim gnevfrfnld lypdategdl ytdmskvdgv lslnvgciqi vylhkflmsl
     1201 lnflnnfqta keslsaataq aaeraatsvk dlaqrsfrvs inidlkapvi vipqssistn
     1261 avvvdlglir vhnqfslvsd edylnppvid rmdvqltklt lyrtviqpgi yhpdiqllhp
     1321 inleflvnrn laaswyhkvp vveikghlds mnvslnqedl nllfrilten lcegtedldk
     1381 vkprvqetge ikepleisis qdvhdskntl ttgveeirsv diinmllnfe ikevvvtlmk
     1441 ksekkgrplh elnvlqlgme akvktydmta kaylkkismq cfdftdskge plhiinssnv
     1501 tdepllkmll tkadsdgpef ktihdstkqr lkvsfasldl vlhleallsf mdflssaapf
     1561 sepsssekes elkplvgesr siavkavssn isqkdvfdlk itaelnafnv fvcdqkcnia
     1621 dikihgmdas isvkpkqtdv farlkdiivm nvdlqsihkk avsilgdevf rfqltlypda
     1681 tegeayadms kvdgklsfkv gciqivyvhk ffmsllnfln nfqtakeals tatvqaaera
     1741 assmkdlaqk sfrllmdinl kapviiipqs svspnaviad lglirvenkf slvpmehysl
     1801 ppvidkmnie ltqlklsrti lqaslpqndi eilkpvnmll siqrnlaaaw yvqipgmeik
     1861 gklkpmqval seddltvlmk illenlgeas sqpsptqsvq etvrvrkvdv ssvpdhlkeq
     1921 edwtdsklsm nqivslqfdf hfeslsiily nndinqesgv afhndsfqlg elrlhlmass
     1981 gkmfkdgsmn vsvklktctl ddlregiera tsrmidrknd qdnnssmidi sykqdkngsq
     2041 idavldklyv casveflmtv adffikavpq spenvaketq ilprqtatgk vkiekddsvr
     2101 pnmtlkamit dpevvfvasl tkadapalta sfqcnlslst skleqmmeas vrdlkvlacp
     2161 flrekrgkni ttvlqpcslf mekctwasgk qninimvkef iikispiiln tvltimaals
     2221 pktkedgskd tskemenlwg iksindyntw flgvdtatei tesfkgiehs lieencgvvv
     2281 esiqvtlecg lghrtvplll aeskfsgnik nwtslmaava dvtlqvhyyn eihavwepli
     2341 ervegkrqwn lrldvkknpv qdksllpgdd fipepqmaih issgntmnit isksclnvfn
     2401 nlakgfsegt astfdyslkd rapftvknav gvpikvkpnc nlrvmgfpek sdifdvdagq
     2461 nleleyasmv pssqgnlsil srqessfftl tivphgytev anipvarpgr rlynvrnpna
     2521 shsdsvlvqi dategnkvit lrsplqvsay gqqkniffpt cniryk
//
LOCUS       XP_047288698            2523 aa            linear   PRI 05-AUG-2025
DEFINITION  intermembrane lipid transfer protein VPS13C isoform X3 [Homo
            sapiens].
ACCESSION   XP_047288698
VERSION     XP_047288698.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432742.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2523
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2523
                     /product="intermembrane lipid transfer protein VPS13C
                     isoform X3"
                     /calculated_mol_wt=283313
     Region          3..>1323
                     /region_name="MRS6"
                     /note="Vacuolar protein sorting-associated protein
                     [Intracellular trafficking and secretion]; COG5043"
                     /db_xref="CDD:227376"
     Region          1003..>2298
                     /region_name="MRS6"
                     /note="Vacuolar protein sorting-associated protein
                     [Intracellular trafficking and secretion]; COG5043"
                     /db_xref="CDD:227376"
     CDS             1..2523
                     /gene="VPS13C"
                     /gene_synonym="BLTP5C; PARK23"
                     /coded_by="XM_047432742.1:74..7645"
                     /db_xref="GeneID:54832"
                     /db_xref="HGNC:HGNC:23594"
                     /db_xref="MIM:608879"
ORIGIN      
        1 mvlesvvadl lnrflgdyve nlnksqlklg iwggnvaldn lqikenalse ldvpfkvkag
       61 qidkltlkip wknlygeavv atleglyllv vpgasikyda vkeekslqdv kqkelsriee
      121 alqkaaekdk pkeakkdtfv eklatqvikn vqvkitdihi kyeddvtdpk rplsfgvtlg
      181 elslltaneh wtpcilnead kiiyklirld slsaywnvnc smsyqrsreq ildqlkneil
      241 tsgnippnyq yifqpisasa klymnpyaes elktpkldcn ieiqniaiel tkpqylsmid
      301 llesvdymvr napyrkykpy lplhtngrrw wkyaidsvle vhirrytqmw swsnikkhrq
      361 llksykiayk nkltqskvse eiqkeiqdle ktldvfniil arqqaqvevi rsgqklrkks
      421 adtgekrggw fsglwgkkes kkkdeeslip etiddlmtpe ekdklftaig ysesthnltl
      481 pkqyvahimt lklvstsvti renknipeil kiqiiglgtq vsqrpgaqal kveaklehwy
      541 itglrqqdiv pslvasigdt tssllkikfe tnpedspadq tlivqsqpve viydaktvna
      601 vveffqsnkg ldleqitsat lmkleeiker tatglthiie trkvldlrin lkpsylvvpq
      661 tgfhheksdl lildfgtfql nskdqglqkt tnssleeimd kaydkfdvei knvqllfara
      721 eetwkkcrfq hpstmhilqp mdihvelaka mvekdirmar fkvsgglplm hvrisdqkmk
      781 dvlylmnsip lpqkssaqsp erqvssipii sggtkgllgt sllldtvese sddeyfdaed
      841 gepqtcksmk gselkkaaev pneelinlll kfeikevile ftkqqkeedt ilvfnvtqlg
      901 teatmrtfdl tvvsylkkis ldyheiegsk rkplhlisss dkpgldllkv eyikadkngp
      961 sfqtafgkte qtvkvafssl nlllqtqalv asinylttii psddqsisva kevqistekq
     1021 qknstlpkai vssrdsdiid frlfaklnaf cvivcneknn iaeikiqgld sslslqsrkq
     1081 slfarlenii vtdvdpktvh kkavsimgne vfrfnldlyp dategdlytd mskvdgvlsl
     1141 nvgciqivyl hkflmsllnf lnnfqtakes lsaataqaae raatsvkdla qrsfrvsini
     1201 dlkapvivip qssistnavv vdlglirvhn qfslvsdedy lnppvidrmd vqltkltlyr
     1261 tviqpgiyhp diqllhpinl eflvnrnlaa swyhkvpvve ikghldsmnv slnqedlnll
     1321 friltenlce gtedldkvkp rvqetgeike pleisisqdv hdskntlttg veeirsvdii
     1381 nmllnfeike vvvtlmkkse kkgrplheln vlqlgmeakv ktydmtakay lkkismqcfd
     1441 ftdskgeplh iinssnvtde pllkmlltka dsdgpefkti hdstkqrlkv sfasldlvlh
     1501 leallsfmdf lssaapfsep sssekeselk plvgesrsia vkavssnisq kdvfdlkita
     1561 elnafnvfvc dqkcniadik ihgmdasisv kpkqtdvfar lkdiivmnvd lqsihkkavs
     1621 ilgdevfrfq ltlypdateg eayadmskvd gklsfkvgci qivyvhkffm sllnflnnfq
     1681 takealstat vqaaeraass mkdlaqksfr llmdinlkap viiipqssvs pnaviadlgl
     1741 irvenkfslv pmehyslppv idkmnieltq lklsrtilqa slpqndieil kpvnmllsiq
     1801 rnlaaawyvq ipgmeikgkl kpmqvalsed dltvlmkill enlgeassqp sptqsvqetv
     1861 rvrkvdvssv pdhlkeqedw tdsklsmnqi vslqfdfhfe slsiilynnd inqesgvafh
     1921 ndsfqlgelr lhlmassgkm fkdgsmnvsv klktctlddl regieratsr midrkndqdn
     1981 nssmidisyk qdkngsqida vldklyvcas veflmtvadf fikavpqspe nvaketqilp
     2041 rqtatgkvki ekddsvrpnm tlkamitdpe vvfvasltka dapaltasfq cnlslstskl
     2101 eqmmeasvrd lkvlacpflr ekrgknittv lqpcslfmek ctwasgkqni nimvkefiik
     2161 ispiilntvl timaalspkt kedgskdtsk emenlwgiks indyntwflg vdtateites
     2221 fkgiehslie encgvvvesi qvtlecglgh rtvplllaes kfsgniknwt slmaavadvt
     2281 lqvhyyneih avweplierv egkrqwnlrl dvkknpvqdk sllpgddfip epqmaihiss
     2341 gntmnitisk sclnvfnnla kgfsegtast fdyslkdrap ftvknavgvp ikvkpncnlr
     2401 vmgfpeksdi fdvdagqnle leyasmvpss qgnlsilsrq essfftltiv phgytevani
     2461 pvarpgrrly nvrnpnashs dsvlvqidat egnkvitlrs plqvsaygqq kniffptcni
     2521 ryk
//
LOCUS       XP_016877849             330 aa            linear   PRI 05-AUG-2025
DEFINITION  membrane progestin receptor gamma isoform X1 [Homo sapiens].
ACCESSION   XP_016877849
VERSION     XP_016877849.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022360.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..330
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..330
                     /product="membrane progestin receptor gamma isoform X1"
                     /calculated_mol_wt=37883
     Region          43..269
                     /region_name="HlyIII"
                     /note="Haemolysin-III related; pfam03006"
                     /db_xref="CDD:427098"
     CDS             1..330
                     /gene="PAQR5"
                     /gene_synonym="MPRG"
                     /coded_by="XM_017022360.2:768..1760"
                     /db_xref="GeneID:54852"
                     /db_xref="HGNC:HGNC:29645"
                     /db_xref="MIM:607781"
ORIGIN      
        1 mlslklprlf sidqipqvfh eqgilfgyrh pqssatacil slfqmtnetl niwthllpfw
       61 ffawrfvtal ymtdikndsy swpmlvymct scvyplvssc ahtfssmskn arhicyfldy
      121 gavnlfslgs aiaysaytfp dalmcttfhd yyvalavlnt ilstglscys rfleiqkprl
      181 ckvirvlafa ypytwdslpi fyrlflfpge saqneatsyh qkhmimtlla sflysahlpe
      241 rlapgrfdyi ghshqlfhvc vilathmqme ailldktlrk ewllatskpf sfsqiagail
      301 lciifslsni iyfsaalyri pkpelhkket
//
LOCUS       XP_016877851             330 aa            linear   PRI 05-AUG-2025
DEFINITION  membrane progestin receptor gamma isoform X1 [Homo sapiens].
ACCESSION   XP_016877851
VERSION     XP_016877851.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022362.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..330
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..330
                     /product="membrane progestin receptor gamma isoform X1"
                     /calculated_mol_wt=37883
     Region          43..269
                     /region_name="HlyIII"
                     /note="Haemolysin-III related; pfam03006"
                     /db_xref="CDD:427098"
     CDS             1..330
                     /gene="PAQR5"
                     /gene_synonym="MPRG"
                     /coded_by="XM_017022362.2:688..1680"
                     /db_xref="GeneID:54852"
                     /db_xref="HGNC:HGNC:29645"
                     /db_xref="MIM:607781"
ORIGIN      
        1 mlslklprlf sidqipqvfh eqgilfgyrh pqssatacil slfqmtnetl niwthllpfw
       61 ffawrfvtal ymtdikndsy swpmlvymct scvyplvssc ahtfssmskn arhicyfldy
      121 gavnlfslgs aiaysaytfp dalmcttfhd yyvalavlnt ilstglscys rfleiqkprl
      181 ckvirvlafa ypytwdslpi fyrlflfpge saqneatsyh qkhmimtlla sflysahlpe
      241 rlapgrfdyi ghshqlfhvc vilathmqme ailldktlrk ewllatskpf sfsqiagail
      301 lciifslsni iyfsaalyri pkpelhkket
//
LOCUS       XP_011520022             330 aa            linear   PRI 05-AUG-2025
DEFINITION  membrane progestin receptor gamma isoform X1 [Homo sapiens].
ACCESSION   XP_011520022
VERSION     XP_011520022.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521720.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..330
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..330
                     /product="membrane progestin receptor gamma isoform X1"
                     /calculated_mol_wt=37883
     Region          43..269
                     /region_name="HlyIII"
                     /note="Haemolysin-III related; pfam03006"
                     /db_xref="CDD:427098"
     CDS             1..330
                     /gene="PAQR5"
                     /gene_synonym="MPRG"
                     /coded_by="XM_011521720.3:528..1520"
                     /db_xref="GeneID:54852"
                     /db_xref="HGNC:HGNC:29645"
                     /db_xref="MIM:607781"
ORIGIN      
        1 mlslklprlf sidqipqvfh eqgilfgyrh pqssatacil slfqmtnetl niwthllpfw
       61 ffawrfvtal ymtdikndsy swpmlvymct scvyplvssc ahtfssmskn arhicyfldy
      121 gavnlfslgs aiaysaytfp dalmcttfhd yyvalavlnt ilstglscys rfleiqkprl
      181 ckvirvlafa ypytwdslpi fyrlflfpge saqneatsyh qkhmimtlla sflysahlpe
      241 rlapgrfdyi ghshqlfhvc vilathmqme ailldktlrk ewllatskpf sfsqiagail
      301 lciifslsni iyfsaalyri pkpelhkket
//
LOCUS       XP_047288699             330 aa            linear   PRI 05-AUG-2025
DEFINITION  membrane progestin receptor gamma isoform X1 [Homo sapiens].
ACCESSION   XP_047288699
VERSION     XP_047288699.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432743.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..330
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..330
                     /product="membrane progestin receptor gamma isoform X1"
                     /calculated_mol_wt=37883
     Region          43..269
                     /region_name="HlyIII"
                     /note="Haemolysin-III related; pfam03006"
                     /db_xref="CDD:427098"
     CDS             1..330
                     /gene="PAQR5"
                     /gene_synonym="MPRG"
                     /coded_by="XM_047432743.1:582..1574"
                     /db_xref="GeneID:54852"
                     /db_xref="HGNC:HGNC:29645"
                     /db_xref="MIM:607781"
ORIGIN      
        1 mlslklprlf sidqipqvfh eqgilfgyrh pqssatacil slfqmtnetl niwthllpfw
       61 ffawrfvtal ymtdikndsy swpmlvymct scvyplvssc ahtfssmskn arhicyfldy
      121 gavnlfslgs aiaysaytfp dalmcttfhd yyvalavlnt ilstglscys rfleiqkprl
      181 ckvirvlafa ypytwdslpi fyrlflfpge saqneatsyh qkhmimtlla sflysahlpe
      241 rlapgrfdyi ghshqlfhvc vilathmqme ailldktlrk ewllatskpf sfsqiagail
      301 lciifslsni iyfsaalyri pkpelhkket
//
LOCUS       XP_047288700             330 aa            linear   PRI 05-AUG-2025
DEFINITION  membrane progestin receptor gamma isoform X1 [Homo sapiens].
ACCESSION   XP_047288700
VERSION     XP_047288700.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432744.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..330
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..330
                     /product="membrane progestin receptor gamma isoform X1"
                     /calculated_mol_wt=37883
     Region          43..269
                     /region_name="HlyIII"
                     /note="Haemolysin-III related; pfam03006"
                     /db_xref="CDD:427098"
     CDS             1..330
                     /gene="PAQR5"
                     /gene_synonym="MPRG"
                     /coded_by="XM_047432744.1:662..1654"
                     /db_xref="GeneID:54852"
                     /db_xref="HGNC:HGNC:29645"
                     /db_xref="MIM:607781"
ORIGIN      
        1 mlslklprlf sidqipqvfh eqgilfgyrh pqssatacil slfqmtnetl niwthllpfw
       61 ffawrfvtal ymtdikndsy swpmlvymct scvyplvssc ahtfssmskn arhicyfldy
      121 gavnlfslgs aiaysaytfp dalmcttfhd yyvalavlnt ilstglscys rfleiqkprl
      181 ckvirvlafa ypytwdslpi fyrlflfpge saqneatsyh qkhmimtlla sflysahlpe
      241 rlapgrfdyi ghshqlfhvc vilathmqme ailldktlrk ewllatskpf sfsqiagail
      301 lciifslsni iyfsaalyri pkpelhkket
//
LOCUS       XP_024305734             330 aa            linear   PRI 05-AUG-2025
DEFINITION  membrane progestin receptor gamma isoform X1 [Homo sapiens].
ACCESSION   XP_024305734
VERSION     XP_024305734.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449966.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..330
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..330
                     /product="membrane progestin receptor gamma isoform X1"
                     /calculated_mol_wt=37883
     Region          43..269
                     /region_name="HlyIII"
                     /note="Haemolysin-III related; pfam03006"
                     /db_xref="CDD:427098"
     CDS             1..330
                     /gene="PAQR5"
                     /gene_synonym="MPRG"
                     /coded_by="XM_024449966.2:436..1428"
                     /db_xref="GeneID:54852"
                     /db_xref="HGNC:HGNC:29645"
                     /db_xref="MIM:607781"
ORIGIN      
        1 mlslklprlf sidqipqvfh eqgilfgyrh pqssatacil slfqmtnetl niwthllpfw
       61 ffawrfvtal ymtdikndsy swpmlvymct scvyplvssc ahtfssmskn arhicyfldy
      121 gavnlfslgs aiaysaytfp dalmcttfhd yyvalavlnt ilstglscys rfleiqkprl
      181 ckvirvlafa ypytwdslpi fyrlflfpge saqneatsyh qkhmimtlla sflysahlpe
      241 rlapgrfdyi ghshqlfhvc vilathmqme ailldktlrk ewllatskpf sfsqiagail
      301 lciifslsni iyfsaalyri pkpelhkket
//
LOCUS       XP_047288701             330 aa            linear   PRI 05-AUG-2025
DEFINITION  membrane progestin receptor gamma isoform X1 [Homo sapiens].
ACCESSION   XP_047288701
VERSION     XP_047288701.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432745.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..330
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..330
                     /product="membrane progestin receptor gamma isoform X1"
                     /calculated_mol_wt=37883
     Region          43..269
                     /region_name="HlyIII"
                     /note="Haemolysin-III related; pfam03006"
                     /db_xref="CDD:427098"
     CDS             1..330
                     /gene="PAQR5"
                     /gene_synonym="MPRG"
                     /coded_by="XM_047432745.1:542..1534"
                     /db_xref="GeneID:54852"
                     /db_xref="HGNC:HGNC:29645"
                     /db_xref="MIM:607781"
ORIGIN      
        1 mlslklprlf sidqipqvfh eqgilfgyrh pqssatacil slfqmtnetl niwthllpfw
       61 ffawrfvtal ymtdikndsy swpmlvymct scvyplvssc ahtfssmskn arhicyfldy
      121 gavnlfslgs aiaysaytfp dalmcttfhd yyvalavlnt ilstglscys rfleiqkprl
      181 ckvirvlafa ypytwdslpi fyrlflfpge saqneatsyh qkhmimtlla sflysahlpe
      241 rlapgrfdyi ghshqlfhvc vilathmqme ailldktlrk ewllatskpf sfsqiagail
      301 lciifslsni iyfsaalyri pkpelhkket
//
LOCUS       XP_047288702             330 aa            linear   PRI 05-AUG-2025
DEFINITION  membrane progestin receptor gamma isoform X1 [Homo sapiens].
ACCESSION   XP_047288702
VERSION     XP_047288702.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432746.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..330
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..330
                     /product="membrane progestin receptor gamma isoform X1"
                     /calculated_mol_wt=37883
     Region          43..269
                     /region_name="HlyIII"
                     /note="Haemolysin-III related; pfam03006"
                     /db_xref="CDD:427098"
     CDS             1..330
                     /gene="PAQR5"
                     /gene_synonym="MPRG"
                     /coded_by="XM_047432746.1:838..1830"
                     /db_xref="GeneID:54852"
                     /db_xref="HGNC:HGNC:29645"
                     /db_xref="MIM:607781"
ORIGIN      
        1 mlslklprlf sidqipqvfh eqgilfgyrh pqssatacil slfqmtnetl niwthllpfw
       61 ffawrfvtal ymtdikndsy swpmlvymct scvyplvssc ahtfssmskn arhicyfldy
      121 gavnlfslgs aiaysaytfp dalmcttfhd yyvalavlnt ilstglscys rfleiqkprl
      181 ckvirvlafa ypytwdslpi fyrlflfpge saqneatsyh qkhmimtlla sflysahlpe
      241 rlapgrfdyi ghshqlfhvc vilathmqme ailldktlrk ewllatskpf sfsqiagail
      301 lciifslsni iyfsaalyri pkpelhkket
//
LOCUS       XP_047288703             330 aa            linear   PRI 05-AUG-2025
DEFINITION  membrane progestin receptor gamma isoform X1 [Homo sapiens].
ACCESSION   XP_047288703
VERSION     XP_047288703.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432747.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..330
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..330
                     /product="membrane progestin receptor gamma isoform X1"
                     /calculated_mol_wt=37883
     Region          43..269
                     /region_name="HlyIII"
                     /note="Haemolysin-III related; pfam03006"
                     /db_xref="CDD:427098"
     CDS             1..330
                     /gene="PAQR5"
                     /gene_synonym="MPRG"
                     /coded_by="XM_047432747.1:523..1515"
                     /db_xref="GeneID:54852"
                     /db_xref="HGNC:HGNC:29645"
                     /db_xref="MIM:607781"
ORIGIN      
        1 mlslklprlf sidqipqvfh eqgilfgyrh pqssatacil slfqmtnetl niwthllpfw
       61 ffawrfvtal ymtdikndsy swpmlvymct scvyplvssc ahtfssmskn arhicyfldy
      121 gavnlfslgs aiaysaytfp dalmcttfhd yyvalavlnt ilstglscys rfleiqkprl
      181 ckvirvlafa ypytwdslpi fyrlflfpge saqneatsyh qkhmimtlla sflysahlpe
      241 rlapgrfdyi ghshqlfhvc vilathmqme ailldktlrk ewllatskpf sfsqiagail
      301 lciifslsni iyfsaalyri pkpelhkket
//
LOCUS       XP_047288704             330 aa            linear   PRI 05-AUG-2025
DEFINITION  membrane progestin receptor gamma isoform X1 [Homo sapiens].
ACCESSION   XP_047288704
VERSION     XP_047288704.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432748.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..330
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..330
                     /product="membrane progestin receptor gamma isoform X1"
                     /calculated_mol_wt=37883
     Region          43..269
                     /region_name="HlyIII"
                     /note="Haemolysin-III related; pfam03006"
                     /db_xref="CDD:427098"
     CDS             1..330
                     /gene="PAQR5"
                     /gene_synonym="MPRG"
                     /coded_by="XM_047432748.1:1078..2070"
                     /db_xref="GeneID:54852"
                     /db_xref="HGNC:HGNC:29645"
                     /db_xref="MIM:607781"
ORIGIN      
        1 mlslklprlf sidqipqvfh eqgilfgyrh pqssatacil slfqmtnetl niwthllpfw
       61 ffawrfvtal ymtdikndsy swpmlvymct scvyplvssc ahtfssmskn arhicyfldy
      121 gavnlfslgs aiaysaytfp dalmcttfhd yyvalavlnt ilstglscys rfleiqkprl
      181 ckvirvlafa ypytwdslpi fyrlflfpge saqneatsyh qkhmimtlla sflysahlpe
      241 rlapgrfdyi ghshqlfhvc vilathmqme ailldktlrk ewllatskpf sfsqiagail
      301 lciifslsni iyfsaalyri pkpelhkket
//
LOCUS       XP_047288705             330 aa            linear   PRI 05-AUG-2025
DEFINITION  membrane progestin receptor gamma isoform X1 [Homo sapiens].
ACCESSION   XP_047288705
VERSION     XP_047288705.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432749.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..330
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..330
                     /product="membrane progestin receptor gamma isoform X1"
                     /calculated_mol_wt=37883
     Region          43..269
                     /region_name="HlyIII"
                     /note="Haemolysin-III related; pfam03006"
                     /db_xref="CDD:427098"
     CDS             1..330
                     /gene="PAQR5"
                     /gene_synonym="MPRG"
                     /coded_by="XM_047432749.1:1420..2412"
                     /db_xref="GeneID:54852"
                     /db_xref="HGNC:HGNC:29645"
                     /db_xref="MIM:607781"
ORIGIN      
        1 mlslklprlf sidqipqvfh eqgilfgyrh pqssatacil slfqmtnetl niwthllpfw
       61 ffawrfvtal ymtdikndsy swpmlvymct scvyplvssc ahtfssmskn arhicyfldy
      121 gavnlfslgs aiaysaytfp dalmcttfhd yyvalavlnt ilstglscys rfleiqkprl
      181 ckvirvlafa ypytwdslpi fyrlflfpge saqneatsyh qkhmimtlla sflysahlpe
      241 rlapgrfdyi ghshqlfhvc vilathmqme ailldktlrk ewllatskpf sfsqiagail
      301 lciifslsni iyfsaalyri pkpelhkket
//
LOCUS       XP_005254552             316 aa            linear   PRI 05-AUG-2025
DEFINITION  membrane progestin receptor gamma isoform X2 [Homo sapiens].
ACCESSION   XP_005254552
VERSION     XP_005254552.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254495.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..316
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..316
                     /product="membrane progestin receptor gamma isoform X2"
                     /calculated_mol_wt=36286
     Region          29..255
                     /region_name="HlyIII"
                     /note="Haemolysin-III related; pfam03006"
                     /db_xref="CDD:427098"
     CDS             1..316
                     /gene="PAQR5"
                     /gene_synonym="MPRG"
                     /coded_by="XM_005254495.5:145..1095"
                     /db_xref="GeneID:54852"
                     /db_xref="HGNC:HGNC:29645"
                     /db_xref="MIM:607781"
ORIGIN      
        1 mprvfheqgi lfgyrhpqss atacilslfq mtnetlniwt hllpfwffaw rfvtalymtd
       61 ikndsyswpm lvymctscvy plvsscahtf ssmsknarhi cyfldygavn lfslgsaiay
      121 saytfpdalm cttfhdyyva lavlntilst glscysrfle iqkprlckvi rvlafaypyt
      181 wdslpifyrl flfpgesaqn eatsyhqkhm imtllasfly sahlperlap grfdyighsh
      241 qlfhvcvila thmqmeaill dktlrkewll atskpfsfsq iagaillcii fslsniiyfs
      301 aalyripkpe lhkket
//
LOCUS       XP_024305735             263 aa            linear   PRI 05-AUG-2025
DEFINITION  membrane progestin receptor gamma isoform X3 [Homo sapiens].
ACCESSION   XP_024305735
VERSION     XP_024305735.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449967.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..263
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..263
                     /product="membrane progestin receptor gamma isoform X3"
                     /calculated_mol_wt=29736
     Region          <112..202
                     /region_name="HlyIII"
                     /note="Haemolysin-III related; cl03831"
                     /db_xref="CDD:470885"
     CDS             1..263
                     /gene="PAQR5"
                     /gene_synonym="MPRG"
                     /coded_by="XM_024449967.2:2527..3318"
                     /db_xref="GeneID:54852"
                     /db_xref="HGNC:HGNC:29645"
                     /db_xref="MIM:607781"
ORIGIN      
        1 mlrlwfcsgc gdiawpnael qlgsgrplsr atgpsaffsl llslfssafs pslfpldpal
       61 qlerlvrlpl gkhfirpsem lsqvtenpcf ggwpspatar flrvfleiqk prlckvirvl
      121 afaypytwds lpifyrlflf pgesaqneat syhqkhmimt llasflysah lperlapgrf
      181 dyighshqlf hvcvilathm qmeailldkt lrkewllats kpfsfsqiag aillciifsl
      241 sniiyfsaal yripkpelhk ket
//
LOCUS       XP_011520027             219 aa            linear   PRI 05-AUG-2025
DEFINITION  membrane progestin receptor gamma isoform X4 [Homo sapiens].
ACCESSION   XP_011520027
VERSION     XP_011520027.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521725.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..219
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..219
                     /product="membrane progestin receptor gamma isoform X4"
                     /calculated_mol_wt=25330
     Region          <68..158
                     /region_name="HlyIII"
                     /note="Haemolysin-III related; cl03831"
                     /db_xref="CDD:470885"
     CDS             1..219
                     /gene="PAQR5"
                     /gene_synonym="MPRG"
                     /coded_by="XM_011521725.3:422..1081"
                     /db_xref="GeneID:54852"
                     /db_xref="HGNC:HGNC:29645"
                     /db_xref="MIM:607781"
ORIGIN      
        1 mlslklprlf sidqipqvfh eqgilfgyrh pqssatacil slfqmtnetl niwthllpfw
       61 fleiqkprlc kvirvlafay pytwdslpif yrlflfpges aqneatsyhq khmimtllas
      121 flysahlper lapgrfdyig hshqlfhvcv ilathmqmea illdktlrke wllatskpfs
      181 fsqiagaill ciifslsnii yfsaalyrip kpelhkket
//
LOCUS       XP_047288706             219 aa            linear   PRI 05-AUG-2025
DEFINITION  membrane progestin receptor gamma isoform X4 [Homo sapiens].
ACCESSION   XP_047288706
VERSION     XP_047288706.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432750.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..219
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..219
                     /product="membrane progestin receptor gamma isoform X4"
                     /calculated_mol_wt=25330
     Region          <68..158
                     /region_name="HlyIII"
                     /note="Haemolysin-III related; cl03831"
                     /db_xref="CDD:470885"
     CDS             1..219
                     /gene="PAQR5"
                     /gene_synonym="MPRG"
                     /coded_by="XM_047432750.1:528..1187"
                     /db_xref="GeneID:54852"
                     /db_xref="HGNC:HGNC:29645"
                     /db_xref="MIM:607781"
ORIGIN      
        1 mlslklprlf sidqipqvfh eqgilfgyrh pqssatacil slfqmtnetl niwthllpfw
       61 fleiqkprlc kvirvlafay pytwdslpif yrlflfpges aqneatsyhq khmimtllas
      121 flysahlper lapgrfdyig hshqlfhvcv ilathmqmea illdktlrke wllatskpfs
      181 fsqiagaill ciifslsnii yfsaalyrip kpelhkket
//
LOCUS       XP_047288707             219 aa            linear   PRI 05-AUG-2025
DEFINITION  membrane progestin receptor gamma isoform X4 [Homo sapiens].
ACCESSION   XP_047288707
VERSION     XP_047288707.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432751.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..219
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..219
                     /product="membrane progestin receptor gamma isoform X4"
                     /calculated_mol_wt=25330
     Region          <68..158
                     /region_name="HlyIII"
                     /note="Haemolysin-III related; cl03831"
                     /db_xref="CDD:470885"
     CDS             1..219
                     /gene="PAQR5"
                     /gene_synonym="MPRG"
                     /coded_by="XM_047432751.1:582..1241"
                     /db_xref="GeneID:54852"
                     /db_xref="HGNC:HGNC:29645"
                     /db_xref="MIM:607781"
ORIGIN      
        1 mlslklprlf sidqipqvfh eqgilfgyrh pqssatacil slfqmtnetl niwthllpfw
       61 fleiqkprlc kvirvlafay pytwdslpif yrlflfpges aqneatsyhq khmimtllas
      121 flysahlper lapgrfdyig hshqlfhvcv ilathmqmea illdktlrke wllatskpfs
      181 fsqiagaill ciifslsnii yfsaalyrip kpelhkket
//
LOCUS       XP_047288708             215 aa            linear   PRI 05-AUG-2025
DEFINITION  membrane progestin receptor gamma isoform X5 [Homo sapiens].
ACCESSION   XP_047288708
VERSION     XP_047288708.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432752.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..215
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..215
                     /product="membrane progestin receptor gamma isoform X5"
                     /calculated_mol_wt=24370
     Region          <14..154
                     /region_name="HlyIII"
                     /note="Haemolysin-III related; cl03831"
                     /db_xref="CDD:470885"
     CDS             1..215
                     /gene="PAQR5"
                     /gene_synonym="MPRG"
                     /coded_by="XM_047432752.1:49..696"
                     /db_xref="GeneID:54852"
                     /db_xref="HGNC:HGNC:29645"
                     /db_xref="MIM:607781"
ORIGIN      
        1 mrlstfgltc cpsgsaiays aytfpdalmc ttfhdyyval avlntilstg lscysrflei
       61 qkprlckvir vlafaypytw dslpifyrlf lfpgesaqne atsyhqkhmi mtllasflys
      121 ahlperlapg rfdyighshq lfhvcvilat hmqmeailld ktlrkewlla tskpfsfsqi
      181 agaillciif slsniiyfsa alyripkpel hkket
//
LOCUS       XP_011520029             213 aa            linear   PRI 05-AUG-2025
DEFINITION  membrane progestin receptor gamma isoform X6 [Homo sapiens].
ACCESSION   XP_011520029
VERSION     XP_011520029.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521727.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..213
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..213
                     /product="membrane progestin receptor gamma isoform X6"
                     /calculated_mol_wt=24423
     Region          43..>204
                     /region_name="HlyIII"
                     /note="Haemolysin-III related; cl03831"
                     /db_xref="CDD:470885"
     CDS             1..213
                     /gene="PAQR5"
                     /gene_synonym="MPRG"
                     /coded_by="XM_011521727.3:422..1063"
                     /db_xref="GeneID:54852"
                     /db_xref="HGNC:HGNC:29645"
                     /db_xref="MIM:607781"
ORIGIN      
        1 mlslklprlf sidqipqvfh eqgilfgyrh pqssatacil slfqmtnetl niwthllpfw
       61 ffawrfvtal ymtdikndsy swpmlvymct scvyplvssc ahtfssmskn arhicyfldy
      121 gavnlfslgs aiaysaytfp dalmcttfhd yyvalavlnt ilstglscys rfleiqkprl
      181 ckvirvlafa ypytwdslpi fyrvtvtscf tcv
//
LOCUS       XP_047288709             213 aa            linear   PRI 05-AUG-2025
DEFINITION  membrane progestin receptor gamma isoform X6 [Homo sapiens].
ACCESSION   XP_047288709
VERSION     XP_047288709.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432753.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..213
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..213
                     /product="membrane progestin receptor gamma isoform X6"
                     /calculated_mol_wt=24423
     Region          43..>204
                     /region_name="HlyIII"
                     /note="Haemolysin-III related; cl03831"
                     /db_xref="CDD:470885"
     CDS             1..213
                     /gene="PAQR5"
                     /gene_synonym="MPRG"
                     /coded_by="XM_047432753.1:688..1329"
                     /db_xref="GeneID:54852"
                     /db_xref="HGNC:HGNC:29645"
                     /db_xref="MIM:607781"
ORIGIN      
        1 mlslklprlf sidqipqvfh eqgilfgyrh pqssatacil slfqmtnetl niwthllpfw
       61 ffawrfvtal ymtdikndsy swpmlvymct scvyplvssc ahtfssmskn arhicyfldy
      121 gavnlfslgs aiaysaytfp dalmcttfhd yyvalavlnt ilstglscys rfleiqkprl
      181 ckvirvlafa ypytwdslpi fyrvtvtscf tcv
//
LOCUS       XP_016877858             448 aa            linear   PRI 05-AUG-2025
DEFINITION  creatine kinase U-type, mitochondrial isoform X1 [Homo sapiens].
ACCESSION   XP_016877858
VERSION     XP_016877858.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022369.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..448
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..448
                     /product="creatine kinase U-type, mitochondrial isoform
                     X1"
                     /calculated_mol_wt=50290
     Region          80..437
                     /region_name="creatine_kinase_like"
                     /note="Phosphagen (guanidino) kinases such as creatine
                     kinase and similar enzymes; cd00716"
                     /db_xref="CDD:153076"
     Site            order(136,265,296,347,349)
                     /site_type="other"
                     /note="creatine binding site [chemical binding]"
                     /db_xref="CDD:153076"
     Site            order(192,194,196,255,292,300,356,358..360,384,386,
                     388..389,399)
                     /site_type="other"
                     /note="ADP binding site [chemical binding]"
                     /db_xref="CDD:153076"
     Site            order(381..390,393..402)
                     /site_type="active"
                     /note="substrate specificity loop [active]"
                     /db_xref="CDD:153076"
     CDS             1..448
                     /gene="CKMT1A"
                     /gene_synonym="CKMT1; mia-CK; U-MtCK"
                     /coded_by="XM_017022369.2:430..1776"
                     /db_xref="GeneID:548596"
                     /db_xref="HGNC:HGNC:31736"
                     /db_xref="MIM:613415"
ORIGIN      
        1 magpfsrlls arpglrllal agagslaagf llrpepvraa serrrlypps qtwptgqlpg
       61 nctrsrrlcp psmvtgyplp saeypdlrkh nncmashltp avyarlcdkt tptgwtldqc
      121 iqtgvdnpgh pfiktvgmva gdeetyevfa dlfdpviqer hngydprtmk httdldaski
      181 rsgyfderyv lssrvrtgrs irglslppac traerrever vvvdalsglk gdlagryyrl
      241 semteaeqqq liddhflfdk pvsplltaag mardwpdarg iwhnneksfl iwvneedhtr
      301 vismekggnm krvferfcrg lkeverliqe rgwefmwner lgyiltcpsn lgtglragvh
      361 iklpllskds rfpkilenlr lqkrgtggvd taatggvfdi snldrlgkse velvqlvidg
      421 vnylidcerr lergqdirip tpvihtkh
//
LOCUS       XP_016877859             448 aa            linear   PRI 05-AUG-2025
DEFINITION  creatine kinase U-type, mitochondrial isoform X1 [Homo sapiens].
ACCESSION   XP_016877859
VERSION     XP_016877859.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022370.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..448
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..448
                     /product="creatine kinase U-type, mitochondrial isoform
                     X1"
                     /calculated_mol_wt=50290
     Region          80..437
                     /region_name="creatine_kinase_like"
                     /note="Phosphagen (guanidino) kinases such as creatine
                     kinase and similar enzymes; cd00716"
                     /db_xref="CDD:153076"
     Site            order(136,265,296,347,349)
                     /site_type="other"
                     /note="creatine binding site [chemical binding]"
                     /db_xref="CDD:153076"
     Site            order(192,194,196,255,292,300,356,358..360,384,386,
                     388..389,399)
                     /site_type="other"
                     /note="ADP binding site [chemical binding]"
                     /db_xref="CDD:153076"
     Site            order(381..390,393..402)
                     /site_type="active"
                     /note="substrate specificity loop [active]"
                     /db_xref="CDD:153076"
     CDS             1..448
                     /gene="CKMT1A"
                     /gene_synonym="CKMT1; mia-CK; U-MtCK"
                     /coded_by="XM_017022370.2:355..1701"
                     /db_xref="GeneID:548596"
                     /db_xref="HGNC:HGNC:31736"
                     /db_xref="MIM:613415"
ORIGIN      
        1 magpfsrlls arpglrllal agagslaagf llrpepvraa serrrlypps qtwptgqlpg
       61 nctrsrrlcp psmvtgyplp saeypdlrkh nncmashltp avyarlcdkt tptgwtldqc
      121 iqtgvdnpgh pfiktvgmva gdeetyevfa dlfdpviqer hngydprtmk httdldaski
      181 rsgyfderyv lssrvrtgrs irglslppac traerrever vvvdalsglk gdlagryyrl
      241 semteaeqqq liddhflfdk pvsplltaag mardwpdarg iwhnneksfl iwvneedhtr
      301 vismekggnm krvferfcrg lkeverliqe rgwefmwner lgyiltcpsn lgtglragvh
      361 iklpllskds rfpkilenlr lqkrgtggvd taatggvfdi snldrlgkse velvqlvidg
      421 vnylidcerr lergqdirip tpvihtkh
//
LOCUS       XP_047288710             417 aa            linear   PRI 05-AUG-2025
DEFINITION  creatine kinase U-type, mitochondrial isoform X2 [Homo sapiens].
ACCESSION   XP_047288710
VERSION     XP_047288710.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432754.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..417
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..417
                     /product="creatine kinase U-type, mitochondrial isoform
                     X2"
                     /calculated_mol_wt=46906
     Region          49..406
                     /region_name="creatine_kinase_like"
                     /note="Phosphagen (guanidino) kinases such as creatine
                     kinase and similar enzymes; cd00716"
                     /db_xref="CDD:153076"
     Site            order(105,234,265,316,318)
                     /site_type="other"
                     /note="creatine binding site [chemical binding]"
                     /db_xref="CDD:153076"
     Site            order(161,163,165,224,261,269,325,327..329,353,355,
                     357..358,368)
                     /site_type="other"
                     /note="ADP binding site [chemical binding]"
                     /db_xref="CDD:153076"
     Site            order(350..359,362..371)
                     /site_type="active"
                     /note="substrate specificity loop [active]"
                     /db_xref="CDD:153076"
     CDS             1..417
                     /gene="CKMT1A"
                     /gene_synonym="CKMT1; mia-CK; U-MtCK"
                     /coded_by="XM_047432754.1:430..1683"
                     /db_xref="GeneID:548596"
                     /db_xref="HGNC:HGNC:31736"
                     /db_xref="MIM:613415"
ORIGIN      
        1 magpfsrlls arpglrllal agagslaagf llrpepvraa serrrlypps aeypdlrkhn
       61 ncmashltpa vyarlcdktt ptgwtldqci qtgvdnpghp fiktvgmvag deetyevfad
      121 lfdpviqerh ngydprtmkh ttdldaskir sgyfderyvl ssrvrtgrsi rglslppact
      181 raerreverv vvdalsglkg dlagryyrls emteaeqqql iddhflfdkp vsplltaagm
      241 ardwpdargi whnneksfli wvneedhtrv ismekggnmk rvferfcrgl keverliqer
      301 gwefmwnerl gyiltcpsnl gtglragvhi klpllskdsr fpkilenlrl qkrgtggvdt
      361 aatggvfdis nldrlgksev elvqlvidgv nylidcerrl ergqdiript pvihtkh
//
LOCUS       XP_047288711             417 aa            linear   PRI 05-AUG-2025
DEFINITION  creatine kinase U-type, mitochondrial isoform X2 [Homo sapiens].
ACCESSION   XP_047288711
VERSION     XP_047288711.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432755.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..417
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..417
                     /product="creatine kinase U-type, mitochondrial isoform
                     X2"
                     /calculated_mol_wt=46906
     Region          49..406
                     /region_name="creatine_kinase_like"
                     /note="Phosphagen (guanidino) kinases such as creatine
                     kinase and similar enzymes; cd00716"
                     /db_xref="CDD:153076"
     Site            order(105,234,265,316,318)
                     /site_type="other"
                     /note="creatine binding site [chemical binding]"
                     /db_xref="CDD:153076"
     Site            order(161,163,165,224,261,269,325,327..329,353,355,
                     357..358,368)
                     /site_type="other"
                     /note="ADP binding site [chemical binding]"
                     /db_xref="CDD:153076"
     Site            order(350..359,362..371)
                     /site_type="active"
                     /note="substrate specificity loop [active]"
                     /db_xref="CDD:153076"
     CDS             1..417
                     /gene="CKMT1A"
                     /gene_synonym="CKMT1; mia-CK; U-MtCK"
                     /coded_by="XM_047432755.1:355..1608"
                     /db_xref="GeneID:548596"
                     /db_xref="HGNC:HGNC:31736"
                     /db_xref="MIM:613415"
ORIGIN      
        1 magpfsrlls arpglrllal agagslaagf llrpepvraa serrrlypps aeypdlrkhn
       61 ncmashltpa vyarlcdktt ptgwtldqci qtgvdnpghp fiktvgmvag deetyevfad
      121 lfdpviqerh ngydprtmkh ttdldaskir sgyfderyvl ssrvrtgrsi rglslppact
      181 raerreverv vvdalsglkg dlagryyrls emteaeqqql iddhflfdkp vsplltaagm
      241 ardwpdargi whnneksfli wvneedhtrv ismekggnmk rvferfcrgl keverliqer
      301 gwefmwnerl gyiltcpsnl gtglragvhi klpllskdsr fpkilenlrl qkrgtggvdt
      361 aatggvfdis nldrlgksev elvqlvidgv nylidcerrl ergqdiript pvihtkh
//
LOCUS       XP_016877860             216 aa            linear   PRI 05-AUG-2025
DEFINITION  creatine kinase U-type, mitochondrial isoform X3 [Homo sapiens].
ACCESSION   XP_016877860
VERSION     XP_016877860.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022371.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..216
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..216
                     /product="creatine kinase U-type, mitochondrial isoform
                     X3"
                     /calculated_mol_wt=23473
     Region          80..>203
                     /region_name="phosphagen_kinases"
                     /note="Phosphagen (guanidino) kinases; cl02823"
                     /db_xref="CDD:470681"
     CDS             1..216
                     /gene="CKMT1A"
                     /gene_synonym="CKMT1; mia-CK; U-MtCK"
                     /coded_by="XM_017022371.2:493..1143"
                     /db_xref="GeneID:548596"
                     /db_xref="HGNC:HGNC:31736"
                     /db_xref="MIM:613415"
ORIGIN      
        1 magpfsrlls arpglrllal agagslaagf llrpepvraa serrrlypps qtwptgqlpg
       61 nctrsrrlcp psmvtgyplp saeypdlrkh nncmashltp avyarlcdkt tptgwtldqc
      121 iqtgvdnpgh pfiktvgmva gdeetyevfa dlfdpviqer hngydprtmk httdldasks
      181 qnwpkhprtq sasslhssra trggtccggc tewpeg
//
LOCUS       XP_047288712             898 aa            linear   PRI 05-AUG-2025
DEFINITION  dipeptidyl peptidase 8 isoform X1 [Homo sapiens].
ACCESSION   XP_047288712
VERSION     XP_047288712.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432756.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..898
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..898
                     /product="dipeptidyl peptidase 8 isoform X1"
                     /calculated_mol_wt=103228
     Region          8..162
                     /region_name="Dpp_8_9_N"
                     /note="Dipeptidyl peptidase 8 and 9 N-terminal; pfam19520"
                     /db_xref="CDD:466112"
     Region          175..595
                     /region_name="DPPIV_N"
                     /note="Dipeptidyl peptidase IV (DPP IV) N-terminal region;
                     pfam00930"
                     /db_xref="CDD:395744"
     Region          687..891
                     /region_name="Peptidase_S9"
                     /note="Prolyl oligopeptidase family; pfam00326"
                     /db_xref="CDD:459761"
     CDS             1..898
                     /gene="DPP8"
                     /gene_synonym="DP8; DPRP-1; DPRP1; MST097; MSTP097;
                     MSTP135; MSTP141"
                     /coded_by="XM_047432756.1:1998..4694"
                     /db_xref="GeneID:54878"
                     /db_xref="HGNC:HGNC:16490"
                     /db_xref="MIM:606819"
ORIGIN      
        1 mwkrseqmki ksgkcnmaaa meteqlgvei fetadceeni esqdrpklep fyveryswsq
       61 lkklladtrk yhgymmakap hdfmfvkrnd pdgphsdriy ylamsgenre ntlfyseipk
      121 tinraavlml swkplldlfq atldygmysr eeellrerkr igtvgiasyd yhqgsgtflf
      181 qagsgiyhvk dggpqgftqq plrpnlvets cpnirmdpkl cpadpdwiaf ihsndiwisn
      241 ivtreerrlt yvhnelanme edarsagvat fvlqeefdry sgywwcpkae ttpsggkilr
      301 ilyeendese veiihvtspm letrradsfr ypktgtanpk vtfkmseimi daegriidvi
      361 dkeliqpfei lfegveyiar agwtpegkya wsilldrsqt rlqivlispe lfipveddvm
      421 erqrliesvp dsvtpliiye ettdiwinih difhvfpqsh eeeiefifas ecktgfrhly
      481 kitsilkesk ykrssgglpa psdfkcpike eiaitsgewe vlgrhgsniq vdevrrlvyf
      541 egtkdspleh hlyvvsyvnp gevtrltdrg yshsccisqh cdffiskysn qknphcvsly
      601 klsspeddpt cktkefwati ldsagplpdy tppeifsfes ttgftlygml ykphdlqpgk
      661 kyptvlfiyg gpqvqlvnnr fkgvkyfrln tlaslgyvvv vidnrgschr glkfegafky
      721 kmgqieiddq veglqylasr ydfidldrvg ihgwsyggyl slmalmqrsd ifrvaiagap
      781 vtlwifydtg yterymghpd qneqgyylgs vamqaekfps epnrllllhg fldenvhfah
      841 tsillsflvr agkpydlqiy pqerhsirvp esgehyelhl lhylqenlgs riaalkvi
//
LOCUS       XP_047288713             898 aa            linear   PRI 05-AUG-2025
DEFINITION  dipeptidyl peptidase 8 isoform X1 [Homo sapiens].
ACCESSION   XP_047288713
VERSION     XP_047288713.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432757.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..898
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..898
                     /product="dipeptidyl peptidase 8 isoform X1"
                     /calculated_mol_wt=103228
     Region          8..162
                     /region_name="Dpp_8_9_N"
                     /note="Dipeptidyl peptidase 8 and 9 N-terminal; pfam19520"
                     /db_xref="CDD:466112"
     Region          175..595
                     /region_name="DPPIV_N"
                     /note="Dipeptidyl peptidase IV (DPP IV) N-terminal region;
                     pfam00930"
                     /db_xref="CDD:395744"
     Region          687..891
                     /region_name="Peptidase_S9"
                     /note="Prolyl oligopeptidase family; pfam00326"
                     /db_xref="CDD:459761"
     CDS             1..898
                     /gene="DPP8"
                     /gene_synonym="DP8; DPRP-1; DPRP1; MST097; MSTP097;
                     MSTP135; MSTP141"
                     /coded_by="XM_047432757.1:355..3051"
                     /db_xref="GeneID:54878"
                     /db_xref="HGNC:HGNC:16490"
                     /db_xref="MIM:606819"
ORIGIN      
        1 mwkrseqmki ksgkcnmaaa meteqlgvei fetadceeni esqdrpklep fyveryswsq
       61 lkklladtrk yhgymmakap hdfmfvkrnd pdgphsdriy ylamsgenre ntlfyseipk
      121 tinraavlml swkplldlfq atldygmysr eeellrerkr igtvgiasyd yhqgsgtflf
      181 qagsgiyhvk dggpqgftqq plrpnlvets cpnirmdpkl cpadpdwiaf ihsndiwisn
      241 ivtreerrlt yvhnelanme edarsagvat fvlqeefdry sgywwcpkae ttpsggkilr
      301 ilyeendese veiihvtspm letrradsfr ypktgtanpk vtfkmseimi daegriidvi
      361 dkeliqpfei lfegveyiar agwtpegkya wsilldrsqt rlqivlispe lfipveddvm
      421 erqrliesvp dsvtpliiye ettdiwinih difhvfpqsh eeeiefifas ecktgfrhly
      481 kitsilkesk ykrssgglpa psdfkcpike eiaitsgewe vlgrhgsniq vdevrrlvyf
      541 egtkdspleh hlyvvsyvnp gevtrltdrg yshsccisqh cdffiskysn qknphcvsly
      601 klsspeddpt cktkefwati ldsagplpdy tppeifsfes ttgftlygml ykphdlqpgk
      661 kyptvlfiyg gpqvqlvnnr fkgvkyfrln tlaslgyvvv vidnrgschr glkfegafky
      721 kmgqieiddq veglqylasr ydfidldrvg ihgwsyggyl slmalmqrsd ifrvaiagap
      781 vtlwifydtg yterymghpd qneqgyylgs vamqaekfps epnrllllhg fldenvhfah
      841 tsillsflvr agkpydlqiy pqerhsirvp esgehyelhl lhylqenlgs riaalkvi
//
LOCUS       XP_011520032             855 aa            linear   PRI 05-AUG-2025
DEFINITION  dipeptidyl peptidase 8 isoform X2 [Homo sapiens].
ACCESSION   XP_011520032
VERSION     XP_011520032.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521730.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..855
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..855
                     /product="dipeptidyl peptidase 8 isoform X2"
                     /calculated_mol_wt=98296
     Region          8..162
                     /region_name="Dpp_8_9_N"
                     /note="Dipeptidyl peptidase 8 and 9 N-terminal; pfam19520"
                     /db_xref="CDD:466112"
     Region          175..552
                     /region_name="DPPIV_N"
                     /note="Dipeptidyl peptidase IV (DPP IV) N-terminal region;
                     pfam00930"
                     /db_xref="CDD:395744"
     Region          644..848
                     /region_name="Peptidase_S9"
                     /note="Prolyl oligopeptidase family; pfam00326"
                     /db_xref="CDD:459761"
     CDS             1..855
                     /gene="DPP8"
                     /gene_synonym="DP8; DPRP-1; DPRP1; MST097; MSTP097;
                     MSTP135; MSTP141"
                     /coded_by="XM_011521730.3:1998..4565"
                     /db_xref="GeneID:54878"
                     /db_xref="HGNC:HGNC:16490"
                     /db_xref="MIM:606819"
ORIGIN      
        1 mwkrseqmki ksgkcnmaaa meteqlgvei fetadceeni esqdrpklep fyveryswsq
       61 lkklladtrk yhgymmakap hdfmfvkrnd pdgphsdriy ylamsgenre ntlfyseipk
      121 tinraavlml swkplldlfq atldygmysr eeellrerkr igtvgiasyd yhqgsgtflf
      181 qagsgiyhvk dggpqgftqq plrpnlvets cpnirmdpkl cpadpdwiaf ihsndiwisn
      241 ivtreerrlt yvhnelanme edarsagvat fvlqeefdry sgywwcpkae tstanpkvtf
      301 kmseimidae griidvidke liqpfeilfe gveyiaragw tpegkyawsi lldrsqtrlq
      361 ivlispelfi pveddvmerq rliesvpdsv tpliiyeett diwinihdif hvfpqsheee
      421 iefifaseck tgfrhlykit silkeskykr ssgglpapsd fkcpikeeia itsgewevlg
      481 rhgsniqvde vrrlvyfegt kdsplehhly vvsyvnpgev trltdrgysh sccisqhcdf
      541 fiskysnqkn phcvslykls speddptckt kefwatilds agplpdytpp eifsfesttg
      601 ftlygmlykp hdlqpgkkyp tvlfiyggpq vqlvnnrfkg vkyfrlntla slgyvvvvid
      661 nrgschrglk fegafkykmg qieiddqveg lqylasrydf idldrvgihg wsyggylslm
      721 almqrsdifr vaiagapvtl wifydtgyte rymghpdqne qgyylgsvam qaekfpsepn
      781 rllllhgfld envhfahtsi llsflvragk pydlqiypqe rhsirvpesg ehyelhllhy
      841 lqenlgsria alkvi
//
LOCUS       XP_047288714             855 aa            linear   PRI 05-AUG-2025
DEFINITION  dipeptidyl peptidase 8 isoform X2 [Homo sapiens].
ACCESSION   XP_047288714
VERSION     XP_047288714.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432758.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..855
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..855
                     /product="dipeptidyl peptidase 8 isoform X2"
                     /calculated_mol_wt=98296
     Region          8..162
                     /region_name="Dpp_8_9_N"
                     /note="Dipeptidyl peptidase 8 and 9 N-terminal; pfam19520"
                     /db_xref="CDD:466112"
     Region          175..552
                     /region_name="DPPIV_N"
                     /note="Dipeptidyl peptidase IV (DPP IV) N-terminal region;
                     pfam00930"
                     /db_xref="CDD:395744"
     Region          644..848
                     /region_name="Peptidase_S9"
                     /note="Prolyl oligopeptidase family; pfam00326"
                     /db_xref="CDD:459761"
     CDS             1..855
                     /gene="DPP8"
                     /gene_synonym="DP8; DPRP-1; DPRP1; MST097; MSTP097;
                     MSTP135; MSTP141"
                     /coded_by="XM_047432758.1:169..2736"
                     /db_xref="GeneID:54878"
                     /db_xref="HGNC:HGNC:16490"
                     /db_xref="MIM:606819"
ORIGIN      
        1 mwkrseqmki ksgkcnmaaa meteqlgvei fetadceeni esqdrpklep fyveryswsq
       61 lkklladtrk yhgymmakap hdfmfvkrnd pdgphsdriy ylamsgenre ntlfyseipk
      121 tinraavlml swkplldlfq atldygmysr eeellrerkr igtvgiasyd yhqgsgtflf
      181 qagsgiyhvk dggpqgftqq plrpnlvets cpnirmdpkl cpadpdwiaf ihsndiwisn
      241 ivtreerrlt yvhnelanme edarsagvat fvlqeefdry sgywwcpkae tstanpkvtf
      301 kmseimidae griidvidke liqpfeilfe gveyiaragw tpegkyawsi lldrsqtrlq
      361 ivlispelfi pveddvmerq rliesvpdsv tpliiyeett diwinihdif hvfpqsheee
      421 iefifaseck tgfrhlykit silkeskykr ssgglpapsd fkcpikeeia itsgewevlg
      481 rhgsniqvde vrrlvyfegt kdsplehhly vvsyvnpgev trltdrgysh sccisqhcdf
      541 fiskysnqkn phcvslykls speddptckt kefwatilds agplpdytpp eifsfesttg
      601 ftlygmlykp hdlqpgkkyp tvlfiyggpq vqlvnnrfkg vkyfrlntla slgyvvvvid
      661 nrgschrglk fegafkykmg qieiddqveg lqylasrydf idldrvgihg wsyggylslm
      721 almqrsdifr vaiagapvtl wifydtgyte rymghpdqne qgyylgsvam qaekfpsepn
      781 rllllhgfld envhfahtsi llsflvragk pydlqiypqe rhsirvpesg ehyelhllhy
      841 lqenlgsria alkvi
//
LOCUS       XP_011520033             840 aa            linear   PRI 05-AUG-2025
DEFINITION  dipeptidyl peptidase 8 isoform X3 [Homo sapiens].
ACCESSION   XP_011520033
VERSION     XP_011520033.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521731.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..840
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..840
                     /product="dipeptidyl peptidase 8 isoform X3"
                     /calculated_mol_wt=96814
     Region          8..143
                     /region_name="Dpp_8_9_N"
                     /note="Dipeptidyl peptidase 8 and 9 N-terminal; pfam19520"
                     /db_xref="CDD:466112"
     Region          142..537
                     /region_name="DPPIV_N"
                     /note="Dipeptidyl peptidase IV (DPP IV) N-terminal region;
                     pfam00930"
                     /db_xref="CDD:395744"
     Region          629..833
                     /region_name="Peptidase_S9"
                     /note="Prolyl oligopeptidase family; pfam00326"
                     /db_xref="CDD:459761"
     CDS             1..840
                     /gene="DPP8"
                     /gene_synonym="DP8; DPRP-1; DPRP1; MST097; MSTP097;
                     MSTP135; MSTP141"
                     /coded_by="XM_011521731.3:1998..4520"
                     /db_xref="GeneID:54878"
                     /db_xref="HGNC:HGNC:16490"
                     /db_xref="MIM:606819"
ORIGIN      
        1 mwkrseqmki ksgkcnmaaa meteqlgvei fetadceeni esqdrpklep fyveryswsq
       61 lkklladtrk yhgymmakap hdfmfvkrnd pdgphsdriy ylamsgenre ntlfyseipk
      121 tinraavlml swkplldlfq qqplrpnlve tscpnirmdp klcpadpdwi afihsndiwi
      181 snivtreerr ltyvhnelan meedarsagv atfvlqeefd rysgywwcpk aettpsggki
      241 lrilyeende seveiihvts pmletrrads frypktgtan pkvtfkmsei midaegriid
      301 vidkeliqpf eilfegveyi aragwtpegk yawsilldrs qtrlqivlis pelfipvedd
      361 vmerqrlies vpdsvtplii yeettdiwin ihdifhvfpq sheeeiefif asecktgfrh
      421 lykitsilke skykrssggl papsdfkcpi keeiaitsge wevlgrhgsn iqvdevrrlv
      481 yfegtkdspl ehhlyvvsyv npgevtrltd rgyshsccis qhcdffisky snqknphcvs
      541 lyklsspedd ptcktkefwa tildsagplp dytppeifsf esttgftlyg mlykphdlqp
      601 gkkyptvlfi yggpqvqlvn nrfkgvkyfr lntlaslgyv vvvidnrgsc hrglkfegaf
      661 kykmgqieid dqveglqyla srydfidldr vgihgwsygg ylslmalmqr sdifrvaiag
      721 apvtlwifyd tgyterymgh pdqneqgyyl gsvamqaekf psepnrllll hgfldenvhf
      781 ahtsillsfl vragkpydlq iypqerhsir vpesgehyel hllhylqenl gsriaalkvi
//
LOCUS       XP_011520034             829 aa            linear   PRI 05-AUG-2025
DEFINITION  dipeptidyl peptidase 8 isoform X5 [Homo sapiens].
ACCESSION   XP_011520034
VERSION     XP_011520034.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521732.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..829
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..829
                     /product="dipeptidyl peptidase 8 isoform X5"
                     /calculated_mol_wt=95221
     Region          8..162
                     /region_name="Dpp_8_9_N"
                     /note="Dipeptidyl peptidase 8 and 9 N-terminal; pfam19520"
                     /db_xref="CDD:466112"
     Region          175..595
                     /region_name="DPPIV_N"
                     /note="Dipeptidyl peptidase IV (DPP IV) N-terminal region;
                     pfam00930"
                     /db_xref="CDD:395744"
     Region          687..>806
                     /region_name="Peptidase_S9"
                     /note="Prolyl oligopeptidase family; pfam00326"
                     /db_xref="CDD:459761"
     CDS             1..829
                     /gene="DPP8"
                     /gene_synonym="DP8; DPRP-1; DPRP1; MST097; MSTP097;
                     MSTP135; MSTP141"
                     /coded_by="XM_011521732.4:1998..4487"
                     /db_xref="GeneID:54878"
                     /db_xref="HGNC:HGNC:16490"
                     /db_xref="MIM:606819"
ORIGIN      
        1 mwkrseqmki ksgkcnmaaa meteqlgvei fetadceeni esqdrpklep fyveryswsq
       61 lkklladtrk yhgymmakap hdfmfvkrnd pdgphsdriy ylamsgenre ntlfyseipk
      121 tinraavlml swkplldlfq atldygmysr eeellrerkr igtvgiasyd yhqgsgtflf
      181 qagsgiyhvk dggpqgftqq plrpnlvets cpnirmdpkl cpadpdwiaf ihsndiwisn
      241 ivtreerrlt yvhnelanme edarsagvat fvlqeefdry sgywwcpkae ttpsggkilr
      301 ilyeendese veiihvtspm letrradsfr ypktgtanpk vtfkmseimi daegriidvi
      361 dkeliqpfei lfegveyiar agwtpegkya wsilldrsqt rlqivlispe lfipveddvm
      421 erqrliesvp dsvtpliiye ettdiwinih difhvfpqsh eeeiefifas ecktgfrhly
      481 kitsilkesk ykrssgglpa psdfkcpike eiaitsgewe vlgrhgsniq vdevrrlvyf
      541 egtkdspleh hlyvvsyvnp gevtrltdrg yshsccisqh cdffiskysn qknphcvsly
      601 klsspeddpt cktkefwati ldsagplpdy tppeifsfes ttgftlygml ykphdlqpgk
      661 kyptvlfiyg gpqvqlvnnr fkgvkyfrln tlaslgyvvv vidnrgschr glkfegafky
      721 kmgqieiddq veglqylasr ydfidldrvg ihgwsyggyl slmalmqrsd ifrvaiagap
      781 vtlwifydtg yterymghpd qneqgyylgs vamqaekfps esilrrdta
//
LOCUS       XP_011520036             798 aa            linear   PRI 05-AUG-2025
DEFINITION  dipeptidyl peptidase 8 isoform X6 [Homo sapiens].
ACCESSION   XP_011520036
VERSION     XP_011520036.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521734.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..798
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..798
                     /product="dipeptidyl peptidase 8 isoform X6"
                     /calculated_mol_wt=91713
     Region          8..162
                     /region_name="Dpp_8_9_N"
                     /note="Dipeptidyl peptidase 8 and 9 N-terminal; pfam19520"
                     /db_xref="CDD:466112"
     Region          175..595
                     /region_name="DPPIV_N"
                     /note="Dipeptidyl peptidase IV (DPP IV) N-terminal region;
                     pfam00930"
                     /db_xref="CDD:395744"
     Region          <673..791
                     /region_name="Peptidase_S9"
                     /note="Prolyl oligopeptidase family; pfam00326"
                     /db_xref="CDD:459761"
     CDS             1..798
                     /gene="DPP8"
                     /gene_synonym="DP8; DPRP-1; DPRP1; MST097; MSTP097;
                     MSTP135; MSTP141"
                     /coded_by="XM_011521734.3:1998..4394"
                     /db_xref="GeneID:54878"
                     /db_xref="HGNC:HGNC:16490"
                     /db_xref="MIM:606819"
ORIGIN      
        1 mwkrseqmki ksgkcnmaaa meteqlgvei fetadceeni esqdrpklep fyveryswsq
       61 lkklladtrk yhgymmakap hdfmfvkrnd pdgphsdriy ylamsgenre ntlfyseipk
      121 tinraavlml swkplldlfq atldygmysr eeellrerkr igtvgiasyd yhqgsgtflf
      181 qagsgiyhvk dggpqgftqq plrpnlvets cpnirmdpkl cpadpdwiaf ihsndiwisn
      241 ivtreerrlt yvhnelanme edarsagvat fvlqeefdry sgywwcpkae ttpsggkilr
      301 ilyeendese veiihvtspm letrradsfr ypktgtanpk vtfkmseimi daegriidvi
      361 dkeliqpfei lfegveyiar agwtpegkya wsilldrsqt rlqivlispe lfipveddvm
      421 erqrliesvp dsvtpliiye ettdiwinih difhvfpqsh eeeiefifas ecktgfrhly
      481 kitsilkesk ykrssgglpa psdfkcpike eiaitsgewe vlgrhgsniq vdevrrlvyf
      541 egtkdspleh hlyvvsyvnp gevtrltdrg yshsccisqh cdffiskysn qknphcvsly
      601 klsspeddpt cktkefwati ldsagplpdy tppeifsfes ttgftlygml ykphdlqpgk
      661 kyptvlfiyg gpqvaiagap vtlwifydtg yterymghpd qneqgyylgs vamqaekfps
      721 epnrllllhg fldenvhfah tsillsflvr agkpydlqiy pqerhsirvp esgehyelhl
      781 lhylqenlgs riaalkvi
//
LOCUS       XP_047288720             789 aa            linear   PRI 05-AUG-2025
DEFINITION  dipeptidyl peptidase 8 isoform X7 [Homo sapiens].
ACCESSION   XP_047288720
VERSION     XP_047288720.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432764.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..789
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..789
                     /product="dipeptidyl peptidase 8 isoform X7"
                     /calculated_mol_wt=90919
     Region          8..143
                     /region_name="Dpp_8_9_N"
                     /note="Dipeptidyl peptidase 8 and 9 N-terminal; pfam19520"
                     /db_xref="CDD:466112"
     Region          142..537
                     /region_name="DPPIV_N"
                     /note="Dipeptidyl peptidase IV (DPP IV) N-terminal region;
                     pfam00930"
                     /db_xref="CDD:395744"
     Region          576..>648
                     /region_name="FrsA"
                     /note="Fermentation-respiration switch esterase FrsA,
                     DUF1100 family [Signal transduction mechanisms]; COG1073"
                     /db_xref="CDD:440691"
     Region          629..782
                     /region_name="Peptidase_S9"
                     /note="Prolyl oligopeptidase family; pfam00326"
                     /db_xref="CDD:459761"
     CDS             1..789
                     /gene="DPP8"
                     /gene_synonym="DP8; DPRP-1; DPRP1; MST097; MSTP097;
                     MSTP135; MSTP141"
                     /coded_by="XM_047432764.1:1998..4367"
                     /db_xref="GeneID:54878"
                     /db_xref="HGNC:HGNC:16490"
                     /db_xref="MIM:606819"
ORIGIN      
        1 mwkrseqmki ksgkcnmaaa meteqlgvei fetadceeni esqdrpklep fyveryswsq
       61 lkklladtrk yhgymmakap hdfmfvkrnd pdgphsdriy ylamsgenre ntlfyseipk
      121 tinraavlml swkplldlfq qqplrpnlve tscpnirmdp klcpadpdwi afihsndiwi
      181 snivtreerr ltyvhnelan meedarsagv atfvlqeefd rysgywwcpk aettpsggki
      241 lrilyeende seveiihvts pmletrrads frypktgtan pkvtfkmsei midaegriid
      301 vidkeliqpf eilfegveyi aragwtpegk yawsilldrs qtrlqivlis pelfipvedd
      361 vmerqrlies vpdsvtplii yeettdiwin ihdifhvfpq sheeeiefif asecktgfrh
      421 lykitsilke skykrssggl papsdfkcpi keeiaitsge wevlgrhgsn iqvdevrrlv
      481 yfegtkdspl ehhlyvvsyv npgevtrltd rgyshsccis qhcdffisky snqknphcvs
      541 lyklsspedd ptcktkefwa tildsagplp dytppeifsf esttgftlyg mlykphdlqp
      601 gkkyptvlfi yggpqvqlvn nrfkgvkyfr lntlaslgyv vvvidnrgsc hrglkfegaf
      661 kykmvaiaga pvtlwifydt gyterymghp dqneqgyylg svamqaekfp sepnrllllh
      721 gfldenvhfa htsillsflv ragkpydlqi ypqerhsirv pesgehyelh llhylqenlg
      781 sriaalkvi
//
LOCUS       XP_016877867             778 aa            linear   PRI 05-AUG-2025
DEFINITION  dipeptidyl peptidase 8 isoform X8 [Homo sapiens].
ACCESSION   XP_016877867
VERSION     XP_016877867.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022378.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..778
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..778
                     /product="dipeptidyl peptidase 8 isoform X8"
                     /calculated_mol_wt=89326
     Region          8..162
                     /region_name="Dpp_8_9_N"
                     /note="Dipeptidyl peptidase 8 and 9 N-terminal; pfam19520"
                     /db_xref="CDD:466112"
     Region          175..595
                     /region_name="DPPIV_N"
                     /note="Dipeptidyl peptidase IV (DPP IV) N-terminal region;
                     pfam00930"
                     /db_xref="CDD:395744"
     Region          637..>766
                     /region_name="DAP2"
                     /note="Dipeptidyl aminopeptidase/acylaminoacyl peptidase
                     [Amino acid transport and metabolism]; COG1506"
                     /db_xref="CDD:441115"
     CDS             1..778
                     /gene="DPP8"
                     /gene_synonym="DP8; DPRP-1; DPRP1; MST097; MSTP097;
                     MSTP135; MSTP141"
                     /coded_by="XM_017022378.3:1998..4334"
                     /db_xref="GeneID:54878"
                     /db_xref="HGNC:HGNC:16490"
                     /db_xref="MIM:606819"
ORIGIN      
        1 mwkrseqmki ksgkcnmaaa meteqlgvei fetadceeni esqdrpklep fyveryswsq
       61 lkklladtrk yhgymmakap hdfmfvkrnd pdgphsdriy ylamsgenre ntlfyseipk
      121 tinraavlml swkplldlfq atldygmysr eeellrerkr igtvgiasyd yhqgsgtflf
      181 qagsgiyhvk dggpqgftqq plrpnlvets cpnirmdpkl cpadpdwiaf ihsndiwisn
      241 ivtreerrlt yvhnelanme edarsagvat fvlqeefdry sgywwcpkae ttpsggkilr
      301 ilyeendese veiihvtspm letrradsfr ypktgtanpk vtfkmseimi daegriidvi
      361 dkeliqpfei lfegveyiar agwtpegkya wsilldrsqt rlqivlispe lfipveddvm
      421 erqrliesvp dsvtpliiye ettdiwinih difhvfpqsh eeeiefifas ecktgfrhly
      481 kitsilkesk ykrssgglpa psdfkcpike eiaitsgewe vlgrhgsniq vdevrrlvyf
      541 egtkdspleh hlyvvsyvnp gevtrltdrg yshsccisqh cdffiskysn qknphcvsly
      601 klsspeddpt cktkefwati ldsagplpdy tppeifsfes ttgftlygml ykphdlqpgk
      661 kyptvlfiyg gpqvqlvnnr fkgvkyfrln tlaslgyvvv vidnrgschr glkfegafky
      721 kmvaiagapv tlwifydtgy terymghpdq neqgyylgsv amqaekfpse silrrdta
//
LOCUS       XP_047288724             729 aa            linear   PRI 05-AUG-2025
DEFINITION  dipeptidyl peptidase 8 isoform X11 [Homo sapiens].
ACCESSION   XP_047288724
VERSION     XP_047288724.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432768.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..729
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..729
                     /product="dipeptidyl peptidase 8 isoform X11"
                     /calculated_mol_wt=83706
     Region          8..162
                     /region_name="Dpp_8_9_N"
                     /note="Dipeptidyl peptidase 8 and 9 N-terminal; pfam19520"
                     /db_xref="CDD:466112"
     Region          175..595
                     /region_name="DPPIV_N"
                     /note="Dipeptidyl peptidase IV (DPP IV) N-terminal region;
                     pfam00930"
                     /db_xref="CDD:395744"
     Region          637..>673
                     /region_name="DAP2"
                     /note="Dipeptidyl aminopeptidase/acylaminoacyl peptidase
                     [Amino acid transport and metabolism]; COG1506"
                     /db_xref="CDD:441115"
     Region          <673..>706
                     /region_name="Peptidase_S9"
                     /note="Prolyl oligopeptidase family; pfam00326"
                     /db_xref="CDD:459761"
     CDS             1..729
                     /gene="DPP8"
                     /gene_synonym="DP8; DPRP-1; DPRP1; MST097; MSTP097;
                     MSTP135; MSTP141"
                     /coded_by="XM_047432768.1:1998..4187"
                     /db_xref="GeneID:54878"
                     /db_xref="HGNC:HGNC:16490"
                     /db_xref="MIM:606819"
ORIGIN      
        1 mwkrseqmki ksgkcnmaaa meteqlgvei fetadceeni esqdrpklep fyveryswsq
       61 lkklladtrk yhgymmakap hdfmfvkrnd pdgphsdriy ylamsgenre ntlfyseipk
      121 tinraavlml swkplldlfq atldygmysr eeellrerkr igtvgiasyd yhqgsgtflf
      181 qagsgiyhvk dggpqgftqq plrpnlvets cpnirmdpkl cpadpdwiaf ihsndiwisn
      241 ivtreerrlt yvhnelanme edarsagvat fvlqeefdry sgywwcpkae ttpsggkilr
      301 ilyeendese veiihvtspm letrradsfr ypktgtanpk vtfkmseimi daegriidvi
      361 dkeliqpfei lfegveyiar agwtpegkya wsilldrsqt rlqivlispe lfipveddvm
      421 erqrliesvp dsvtpliiye ettdiwinih difhvfpqsh eeeiefifas ecktgfrhly
      481 kitsilkesk ykrssgglpa psdfkcpike eiaitsgewe vlgrhgsniq vdevrrlvyf
      541 egtkdspleh hlyvvsyvnp gevtrltdrg yshsccisqh cdffiskysn qknphcvsly
      601 klsspeddpt cktkefwati ldsagplpdy tppeifsfes ttgftlygml ykphdlqpgk
      661 kyptvlfiyg gpqvaiagap vtlwifydtg yterymghpd qneqgyylgs vamqaekfps
      721 esilrrdta
//
LOCUS       XP_016877871             514 aa            linear   PRI 05-AUG-2025
DEFINITION  dipeptidyl peptidase 8 isoform X12 [Homo sapiens].
ACCESSION   XP_016877871
VERSION     XP_016877871.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022382.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..514
                     /product="dipeptidyl peptidase 8 isoform X12"
                     /calculated_mol_wt=58825
     Region          <7..211
                     /region_name="DPPIV_N"
                     /note="Dipeptidyl peptidase IV (DPP IV) N-terminal region;
                     pfam00930"
                     /db_xref="CDD:395744"
     Region          303..507
                     /region_name="Peptidase_S9"
                     /note="Prolyl oligopeptidase family; pfam00326"
                     /db_xref="CDD:459761"
     CDS             1..514
                     /gene="DPP8"
                     /gene_synonym="DP8; DPRP-1; DPRP1; MST097; MSTP097;
                     MSTP135; MSTP141"
                     /coded_by="XM_017022382.1:153..1697"
                     /db_xref="GeneID:54878"
                     /db_xref="HGNC:HGNC:16490"
                     /db_xref="MIM:606819"
ORIGIN      
        1 mlkegawsil ldrsqtrlqi vlispelfip veddvmerqr liesvpdsvt pliiyeettd
       61 iwinihdifh vfpqsheeei efifaseckt gfrhlykits ilkeskykrs sgglpapsdf
      121 kcpikeeiai tsgewevlgr hgsniqvdev rrlvyfegtk dsplehhlyv vsyvnpgevt
      181 rltdrgyshs ccisqhcdff iskysnqknp hcvslyklss peddptcktk efwatildsa
      241 gplpdytppe ifsfesttgf tlygmlykph dlqpgkkypt vlfiyggpqv qlvnnrfkgv
      301 kyfrlntlas lgyvvvvidn rgschrglkf egafkykmgq ieiddqvegl qylasrydfi
      361 dldrvgihgw syggylslma lmqrsdifrv aiagapvtlw ifydtgyter ymghpdqneq
      421 gyylgsvamq aekfpsepnr llllhgflde nvhfahtsil lsflvragkp ydlqiypqer
      481 hsirvpesge hyelhllhyl qenlgsriaa lkvi
//
LOCUS       XP_016877872             514 aa            linear   PRI 05-AUG-2025
DEFINITION  dipeptidyl peptidase 8 isoform X12 [Homo sapiens].
ACCESSION   XP_016877872
VERSION     XP_016877872.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022383.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..514
                     /product="dipeptidyl peptidase 8 isoform X12"
                     /calculated_mol_wt=58825
     Region          <7..211
                     /region_name="DPPIV_N"
                     /note="Dipeptidyl peptidase IV (DPP IV) N-terminal region;
                     pfam00930"
                     /db_xref="CDD:395744"
     Region          303..507
                     /region_name="Peptidase_S9"
                     /note="Prolyl oligopeptidase family; pfam00326"
                     /db_xref="CDD:459761"
     CDS             1..514
                     /gene="DPP8"
                     /gene_synonym="DP8; DPRP-1; DPRP1; MST097; MSTP097;
                     MSTP135; MSTP141"
                     /coded_by="XM_017022383.2:128..1672"
                     /db_xref="GeneID:54878"
                     /db_xref="HGNC:HGNC:16490"
                     /db_xref="MIM:606819"
ORIGIN      
        1 mlkegawsil ldrsqtrlqi vlispelfip veddvmerqr liesvpdsvt pliiyeettd
       61 iwinihdifh vfpqsheeei efifaseckt gfrhlykits ilkeskykrs sgglpapsdf
      121 kcpikeeiai tsgewevlgr hgsniqvdev rrlvyfegtk dsplehhlyv vsyvnpgevt
      181 rltdrgyshs ccisqhcdff iskysnqknp hcvslyklss peddptcktk efwatildsa
      241 gplpdytppe ifsfesttgf tlygmlykph dlqpgkkypt vlfiyggpqv qlvnnrfkgv
      301 kyfrlntlas lgyvvvvidn rgschrglkf egafkykmgq ieiddqvegl qylasrydfi
      361 dldrvgihgw syggylslma lmqrsdifrv aiagapvtlw ifydtgyter ymghpdqneq
      421 gyylgsvamq aekfpsepnr llllhgflde nvhfahtsil lsflvragkp ydlqiypqer
      481 hsirvpesge hyelhllhyl qenlgsriaa lkvi
//
LOCUS       XP_047288725             504 aa            linear   PRI 05-AUG-2025
DEFINITION  dipeptidyl peptidase 8 isoform X13 [Homo sapiens].
ACCESSION   XP_047288725
VERSION     XP_047288725.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432769.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..504
                     /product="dipeptidyl peptidase 8 isoform X13"
                     /calculated_mol_wt=58171
     Region          8..162
                     /region_name="Dpp_8_9_N"
                     /note="Dipeptidyl peptidase 8 and 9 N-terminal; pfam19520"
                     /db_xref="CDD:466112"
     Region          175..>491
                     /region_name="DPPIV_N"
                     /note="Dipeptidyl peptidase IV (DPP IV) N-terminal region;
                     pfam00930"
                     /db_xref="CDD:395744"
     CDS             1..504
                     /gene="DPP8"
                     /gene_synonym="DP8; DPRP-1; DPRP1; MST097; MSTP097;
                     MSTP135; MSTP141"
                     /coded_by="XM_047432769.1:1998..3512"
                     /db_xref="GeneID:54878"
                     /db_xref="HGNC:HGNC:16490"
                     /db_xref="MIM:606819"
ORIGIN      
        1 mwkrseqmki ksgkcnmaaa meteqlgvei fetadceeni esqdrpklep fyveryswsq
       61 lkklladtrk yhgymmakap hdfmfvkrnd pdgphsdriy ylamsgenre ntlfyseipk
      121 tinraavlml swkplldlfq atldygmysr eeellrerkr igtvgiasyd yhqgsgtflf
      181 qagsgiyhvk dggpqgftqq plrpnlvets cpnirmdpkl cpadpdwiaf ihsndiwisn
      241 ivtreerrlt yvhnelanme edarsagvat fvlqeefdry sgywwcpkae ttpsggkilr
      301 ilyeendese veiihvtspm letrradsfr ypktgtanpk vtfkmseimi daegriidvi
      361 dkeliqpfei lfegveyiar agwtpegkya wsilldrsqt rlqivlispe lfipveddvm
      421 erqrliesvp dsvtpliiye ettdiwinih difhvfpqsh eeeiefifas ecktgfrhly
      481 kitsilkesk ykrssgglpa pnps
//
LOCUS       XP_005254562             479 aa            linear   PRI 05-AUG-2025
DEFINITION  dipeptidyl peptidase 8 isoform X14 [Homo sapiens].
ACCESSION   XP_005254562
VERSION     XP_005254562.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254505.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..479
                     /product="dipeptidyl peptidase 8 isoform X14"
                     /calculated_mol_wt=54818
     Region          <11..176
                     /region_name="DPPIV_N"
                     /note="Dipeptidyl peptidase IV (DPP IV) N-terminal region;
                     pfam00930"
                     /db_xref="CDD:395744"
     Region          268..472
                     /region_name="Peptidase_S9"
                     /note="Prolyl oligopeptidase family; pfam00326"
                     /db_xref="CDD:459761"
     CDS             1..479
                     /gene="DPP8"
                     /gene_synonym="DP8; DPRP-1; DPRP1; MST097; MSTP097;
                     MSTP135; MSTP141"
                     /coded_by="XM_005254505.1:131..1570"
                     /db_xref="GeneID:54878"
                     /db_xref="HGNC:HGNC:16490"
                     /db_xref="MIM:606819"
ORIGIN      
        1 merqrliesv pdsvtpliiy eettdiwini hdifhvfpqs heeeiefifa secktgfrhl
       61 ykitsilkes kykrssgglp apsdfkcpik eeiaitsgew evlgrhgsni qvdevrrlvy
      121 fegtkdsple hhlyvvsyvn pgevtrltdr gyshsccisq hcdffiskys nqknphcvsl
      181 yklsspeddp tcktkefwat ildsagplpd ytppeifsfe sttgftlygm lykphdlqpg
      241 kkyptvlfiy ggpqvqlvnn rfkgvkyfrl ntlaslgyvv vvidnrgsch rglkfegafk
      301 ykmgqieidd qveglqylas rydfidldrv gihgwsyggy lslmalmqrs difrvaiaga
      361 pvtlwifydt gyterymghp dqneqgyylg svamqaekfp sepnrllllh gfldenvhfa
      421 htsillsflv ragkpydlqi ypqerhsirv pesgehyelh llhylqenlg sriaalkvi
//
LOCUS       XP_047288726             529 aa            linear   PRI 05-AUG-2025
DEFINITION  myotubularin-related protein 10 isoform X1 [Homo sapiens].
ACCESSION   XP_047288726
VERSION     XP_047288726.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432770.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..529
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..529
                     /product="myotubularin-related protein 10 isoform X1"
                     /calculated_mol_wt=60374
     Region          31..224
                     /region_name="PTP-MTMR10"
                     /note="protein tyrosine phosphatase-like pseudophosphatase
                     domain of myotubularin related phosphoinositide
                     phosphatase 10; cd14593"
                     /db_xref="CDD:350441"
     Region          326..457
                     /region_name="3-PAP"
                     /note="Myotubularin-associated protein; pfam12578"
                     /db_xref="CDD:463634"
     CDS             1..529
                     /gene="MTMR10"
                     /coded_by="XM_047432770.1:730..2319"
                     /db_xref="GeneID:54893"
                     /db_xref="HGNC:HGNC:25999"
ORIGIN      
        1 mistclpeyi vvpssladqd lkifshsfvg rrmplwcwsh sngsalvrma likdvlqqrk
       61 idqricnait kshpqrsdvy ksdldktlpn iqevqaafvk lkqlcvnepf eeteekwlss
      121 lentrwleyv raflkhsael vymleskhls vvlqeeegrd lsccvaslvq vmldpyfrti
      181 tgfqsliqke wvmagyqfld rcnhlkrsek esplfllfld atwqlleqyp aafefsetyl
      241 avlydstris lfgtflfnsp hqrvkqstef aiskniqlgd ekglkfpsvw dwslqftakd
      301 rtlfhnpfyi gkstpciqng svksfkrtkk sysstlrgmp salkngiisd qellprrnsl
      361 ilkpkpdpaq qtdsqnsdte qyfrewfskp anlhgvilpr vsgthiklwk lcyfrwvpea
      421 qislggsita fhklsllade vdvlsrmlrq qrsgpleacy gelgqsrmyf nasgphhtdt
      481 sgtpeflsss fpfspvgnlc rrsilgtpls kflsgakiwl stetlaned
//
LOCUS       XP_047288727             549 aa            linear   PRI 05-AUG-2025
DEFINITION  myotubularin-related protein 10 isoform X2 [Homo sapiens].
ACCESSION   XP_047288727
VERSION     XP_047288727.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432771.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..549
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..549
                     /product="myotubularin-related protein 10 isoform X2"
                     /calculated_mol_wt=62659
     Region          21..195
                     /region_name="PH-GRAM_MTMR10"
                     /note="Myotubularian (MTM) related 10 protein (MTMR10)
                     Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase
                     activators and Myotubularins (PH-GRAM) domain; cd13346"
                     /db_xref="CDD:270154"
     Region          279..472
                     /region_name="PTP-MTMR10"
                     /note="protein tyrosine phosphatase-like pseudophosphatase
                     domain of myotubularin related phosphoinositide
                     phosphatase 10; cd14593"
                     /db_xref="CDD:350441"
     CDS             1..549
                     /gene="MTMR10"
                     /coded_by="XM_047432771.1:123..1772"
                     /db_xref="GeneID:54893"
                     /db_xref="HGNC:HGNC:25999"
ORIGIN      
        1 mfslkppkpt frsyllpppq tddkinsepk ikklepvllp geivvnevnf vrkciatdts
       61 qydlwgklic snfkisfitd dpmplqkfhy rnlllgehdv pltcieqivt vndhkrkqkv
      121 lgpnqklkfn pteliiyckd frivrfrfde sgpesakkvc laiahysqpt dlqllfafey
      181 vgkkyhnsan kingipsgdg gggggggnga gggssqktpl fetysdwdre ikrtgasgwr
      241 vcsinegymi stclpeyivv pssladqdlk ifshsfvgrr mplwcwshsn gsalvrmali
      301 kdvlqqrkid qricnaitks hpqrsdvyks dldktlpniq evqaafvklk qlcvnepfee
      361 teekwlssle ntrwleyvra flkhsaelvy mleskhlsvv lqeeegrdls ccvaslvqvm
      421 ldpyfrtitg fqsliqkewv magyqfldrc nhlkrsekes plfllfldat wqlleqypaa
      481 fefsetylav lydstrislf gtflfnsphq rvkqstifki syhldlwmtq rtvtemvsag
      541 cghtvprwa
//
LOCUS       XP_011520039             541 aa            linear   PRI 05-AUG-2025
DEFINITION  myotubularin-related protein 10 isoform X3 [Homo sapiens].
ACCESSION   XP_011520039
VERSION     XP_011520039.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521737.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..541
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..541
                     /product="myotubularin-related protein 10 isoform X3"
                     /calculated_mol_wt=61823
     Region          21..195
                     /region_name="PH-GRAM_MTMR10"
                     /note="Myotubularian (MTM) related 10 protein (MTMR10)
                     Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase
                     activators and Myotubularins (PH-GRAM) domain; cd13346"
                     /db_xref="CDD:270154"
     Region          279..472
                     /region_name="PTP-MTMR10"
                     /note="protein tyrosine phosphatase-like pseudophosphatase
                     domain of myotubularin related phosphoinositide
                     phosphatase 10; cd14593"
                     /db_xref="CDD:350441"
     CDS             1..541
                     /gene="MTMR10"
                     /coded_by="XM_011521737.4:123..1748"
                     /db_xref="GeneID:54893"
                     /db_xref="HGNC:HGNC:25999"
ORIGIN      
        1 mfslkppkpt frsyllpppq tddkinsepk ikklepvllp geivvnevnf vrkciatdts
       61 qydlwgklic snfkisfitd dpmplqkfhy rnlllgehdv pltcieqivt vndhkrkqkv
      121 lgpnqklkfn pteliiyckd frivrfrfde sgpesakkvc laiahysqpt dlqllfafey
      181 vgkkyhnsan kingipsgdg gggggggnga gggssqktpl fetysdwdre ikrtgasgwr
      241 vcsinegymi stclpeyivv pssladqdlk ifshsfvgrr mplwcwshsn gsalvrmali
      301 kdvlqqrkid qricnaitks hpqrsdvyks dldktlpniq evqaafvklk qlcvnepfee
      361 teekwlssle ntrwleyvra flkhsaelvy mleskhlsvv lqeeegrdls ccvaslvqvm
      421 ldpyfrtitg fqsliqkewv magyqfldrc nhlkrsekes plfllfldat wqlleqypaa
      481 fefsetylav lydstrislf gtflfnsphq rvkqstltpg qhgfklhtst ymwiffcfch
      541 p
//
LOCUS       XP_011520040             533 aa            linear   PRI 05-AUG-2025
DEFINITION  myotubularin-related protein 10 isoform X4 [Homo sapiens].
ACCESSION   XP_011520040
VERSION     XP_011520040.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521738.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..533
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..533
                     /product="myotubularin-related protein 10 isoform X4"
                     /calculated_mol_wt=60838
     Region          21..195
                     /region_name="PH-GRAM_MTMR10"
                     /note="Myotubularian (MTM) related 10 protein (MTMR10)
                     Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase
                     activators and Myotubularins (PH-GRAM) domain; cd13346"
                     /db_xref="CDD:270154"
     Region          279..472
                     /region_name="PTP-MTMR10"
                     /note="protein tyrosine phosphatase-like pseudophosphatase
                     domain of myotubularin related phosphoinositide
                     phosphatase 10; cd14593"
                     /db_xref="CDD:350441"
     CDS             1..533
                     /gene="MTMR10"
                     /coded_by="XM_011521738.4:123..1724"
                     /db_xref="GeneID:54893"
                     /db_xref="HGNC:HGNC:25999"
ORIGIN      
        1 mfslkppkpt frsyllpppq tddkinsepk ikklepvllp geivvnevnf vrkciatdts
       61 qydlwgklic snfkisfitd dpmplqkfhy rnlllgehdv pltcieqivt vndhkrkqkv
      121 lgpnqklkfn pteliiyckd frivrfrfde sgpesakkvc laiahysqpt dlqllfafey
      181 vgkkyhnsan kingipsgdg gggggggnga gggssqktpl fetysdwdre ikrtgasgwr
      241 vcsinegymi stclpeyivv pssladqdlk ifshsfvgrr mplwcwshsn gsalvrmali
      301 kdvlqqrkid qricnaitks hpqrsdvyks dldktlpniq evqaafvklk qlcvnepfee
      361 teekwlssle ntrwleyvra flkhsaelvy mleskhlsvv lqeeegrdls ccvaslvqvm
      421 ldpyfrtitg fqsliqkewv magyqfldrc nhlkrsekes plfllfldat wqlleqypaa
      481 fefsetylav lydstrislf gtflfnsphq rvkqstvsri ksctkqdyfp srv
//
LOCUS       XP_047288728             529 aa            linear   PRI 05-AUG-2025
DEFINITION  myotubularin-related protein 10 isoform X1 [Homo sapiens].
ACCESSION   XP_047288728
VERSION     XP_047288728.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432772.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..529
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..529
                     /product="myotubularin-related protein 10 isoform X1"
                     /calculated_mol_wt=60374
     Region          31..224
                     /region_name="PTP-MTMR10"
                     /note="protein tyrosine phosphatase-like pseudophosphatase
                     domain of myotubularin related phosphoinositide
                     phosphatase 10; cd14593"
                     /db_xref="CDD:350441"
     Region          326..457
                     /region_name="3-PAP"
                     /note="Myotubularin-associated protein; pfam12578"
                     /db_xref="CDD:463634"
     CDS             1..529
                     /gene="MTMR10"
                     /coded_by="XM_047432772.1:340..1929"
                     /db_xref="GeneID:54893"
                     /db_xref="HGNC:HGNC:25999"
ORIGIN      
        1 mistclpeyi vvpssladqd lkifshsfvg rrmplwcwsh sngsalvrma likdvlqqrk
       61 idqricnait kshpqrsdvy ksdldktlpn iqevqaafvk lkqlcvnepf eeteekwlss
      121 lentrwleyv raflkhsael vymleskhls vvlqeeegrd lsccvaslvq vmldpyfrti
      181 tgfqsliqke wvmagyqfld rcnhlkrsek esplfllfld atwqlleqyp aafefsetyl
      241 avlydstris lfgtflfnsp hqrvkqstef aiskniqlgd ekglkfpsvw dwslqftakd
      301 rtlfhnpfyi gkstpciqng svksfkrtkk sysstlrgmp salkngiisd qellprrnsl
      361 ilkpkpdpaq qtdsqnsdte qyfrewfskp anlhgvilpr vsgthiklwk lcyfrwvpea
      421 qislggsita fhklsllade vdvlsrmlrq qrsgpleacy gelgqsrmyf nasgphhtdt
      481 sgtpeflsss fpfspvgnlc rrsilgtpls kflsgakiwl stetlaned
//
LOCUS       XP_047288729             401 aa            linear   PRI 05-AUG-2025
DEFINITION  myotubularin-related protein 10 isoform X5 [Homo sapiens].
ACCESSION   XP_047288729
VERSION     XP_047288729.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432773.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..401
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..401
                     /product="myotubularin-related protein 10 isoform X5"
                     /calculated_mol_wt=45219
     Region          21..195
                     /region_name="PH-GRAM_MTMR10"
                     /note="Myotubularian (MTM) related 10 protein (MTMR10)
                     Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase
                     activators and Myotubularins (PH-GRAM) domain; cd13346"
                     /db_xref="CDD:270154"
     Region          279..>379
                     /region_name="PTP_DSP_cys"
                     /note="cys-based protein tyrosine phosphatase and
                     dual-specificity phosphatase superfamily; cl28904"
                     /db_xref="CDD:475123"
     CDS             1..401
                     /gene="MTMR10"
                     /coded_by="XM_047432773.1:123..1328"
                     /db_xref="GeneID:54893"
                     /db_xref="HGNC:HGNC:25999"
ORIGIN      
        1 mfslkppkpt frsyllpppq tddkinsepk ikklepvllp geivvnevnf vrkciatdts
       61 qydlwgklic snfkisfitd dpmplqkfhy rnlllgehdv pltcieqivt vndhkrkqkv
      121 lgpnqklkfn pteliiyckd frivrfrfde sgpesakkvc laiahysqpt dlqllfafey
      181 vgkkyhnsan kingipsgdg gggggggnga gggssqktpl fetysdwdre ikrtgasgwr
      241 vcsinegymi stclpeyivv pssladqdlk ifshsfvgrr mplwcwshsn gsalvrmali
      301 kdvlqqrkid qricnaitks hpqrsdvyks dldktlpniq evqaafvklk qlcvnepfee
      361 teekwlssle ntrwleyvrg grkrlellcs fscssdagsl f
//
LOCUS       XP_011520041             229 aa            linear   PRI 05-AUG-2025
DEFINITION  COMM domain-containing protein 4 isoform X1 [Homo sapiens].
ACCESSION   XP_011520041
VERSION     XP_011520041.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521739.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..229
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..229
                     /product="COMM domain-containing protein 4 isoform X1"
                     /calculated_mol_wt=24504
     Region          55..228
                     /region_name="Commd4"
                     /note="COMM_Domain containing protein 4. The COMM Domain
                     is found at the C-terminus of a variety of proteins;
                     presumably all COMM_Domain containing proteins are located
                     in the nucleus and the COMM domain plays a role in
                     protein-protein interactions. Several...; cd04752"
                     /db_xref="CDD:240100"
     CDS             1..229
                     /gene="COMMD4"
                     /coded_by="XM_011521739.3:76..765"
                     /db_xref="GeneID:54939"
                     /db_xref="HGNC:HGNC:26027"
                     /db_xref="MIM:616701"
ORIGIN      
        1 mrgrqvapet gggctglsan tvcagvravs lrfrfcgdld cpdwvlaeis tlakmssvkl
       61 rllcsqvlke llgqgidyek ilkltadakf esgdvkatva vlsfilssaa khsvdgesls
      121 selqqlglpk ehaaslcrcy eekqsplqkh lrvcslrmnr lagvgwrvdy tlsssllqsv
      181 eepmvhlrle vaaapgtpaq pvamslsadk fqvllaelkq aqtlmsslg
//
LOCUS       XP_005254566             226 aa            linear   PRI 05-AUG-2025
DEFINITION  COMM domain-containing protein 4 isoform X2 [Homo sapiens].
ACCESSION   XP_005254566
VERSION     XP_005254566.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254509.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..226
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..226
                     /product="COMM domain-containing protein 4 isoform X2"
                     /calculated_mol_wt=24204
     Region          52..225
                     /region_name="Commd4"
                     /note="COMM_Domain containing protein 4. The COMM Domain
                     is found at the C-terminus of a variety of proteins;
                     presumably all COMM_Domain containing proteins are located
                     in the nucleus and the COMM domain plays a role in
                     protein-protein interactions. Several...; cd04752"
                     /db_xref="CDD:240100"
     CDS             1..226
                     /gene="COMMD4"
                     /coded_by="XM_005254509.4:76..756"
                     /db_xref="GeneID:54939"
                     /db_xref="HGNC:HGNC:26027"
                     /db_xref="MIM:616701"
ORIGIN      
        1 mrgrqvapet gggctglsan tvcagvrarf rfcgdldcpd wvlaeistla kmssvklrll
       61 csqvlkellg qgidyekilk ltadakfesg dvkatvavls filssaakhs vdgeslssel
      121 qqlglpkeha aslcrcyeek qsplqkhlrv cslrmnrlag vgwrvdytls ssllqsveep
      181 mvhlrlevaa apgtpaqpva mslsadkfqv llaelkqaqt lmsslg
//
LOCUS       XP_011520042             207 aa            linear   PRI 05-AUG-2025
DEFINITION  COMM domain-containing protein 4 isoform X3 [Homo sapiens].
ACCESSION   XP_011520042
VERSION     XP_011520042.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521740.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..207
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..207
                     /product="COMM domain-containing protein 4 isoform X3"
                     /calculated_mol_wt=22122
     Region          56..206
                     /region_name="Commd"
                     /note="COMM_Domain, a family of domains found at the
                     C-terminus of HCarG, the copper metabolism gene MURR1
                     product, and related proteins. Presumably all COMM_Domain
                     containing proteins are located in the nucleus and the
                     COMM domain plays a role in...; cl06336"
                     /db_xref="CDD:471425"
     CDS             1..207
                     /gene="COMMD4"
                     /coded_by="XM_011521740.2:76..699"
                     /db_xref="GeneID:54939"
                     /db_xref="HGNC:HGNC:26027"
                     /db_xref="MIM:616701"
ORIGIN      
        1 mrgrqvapet gggctglsan tvcagvravs lrfrfcgdld cpdwvlaeis tlakmyekil
       61 kltadakfes gdvkatvavl sfilssaakh svdgeslsse lqqlglpkeh aaslcrcyee
      121 kqsplqkhlr vcslrmnrla gvgwrvdytl sssllqsvee pmvhlrleva aapgtpaqpv
      181 amslsadkfq vllaelkqaq tlmsslg
//
LOCUS       XP_005254567             204 aa            linear   PRI 05-AUG-2025
DEFINITION  COMM domain-containing protein 4 isoform X4 [Homo sapiens].
ACCESSION   XP_005254567
VERSION     XP_005254567.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254510.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..204
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..204
                     /product="COMM domain-containing protein 4 isoform X4"
                     /calculated_mol_wt=21822
     Region          53..203
                     /region_name="Commd"
                     /note="COMM_Domain, a family of domains found at the
                     C-terminus of HCarG, the copper metabolism gene MURR1
                     product, and related proteins. Presumably all COMM_Domain
                     containing proteins are located in the nucleus and the
                     COMM domain plays a role in...; cl06336"
                     /db_xref="CDD:471425"
     CDS             1..204
                     /gene="COMMD4"
                     /coded_by="XM_005254510.4:76..690"
                     /db_xref="GeneID:54939"
                     /db_xref="HGNC:HGNC:26027"
                     /db_xref="MIM:616701"
ORIGIN      
        1 mrgrqvapet gggctglsan tvcagvrarf rfcgdldcpd wvlaeistla kmyekilklt
       61 adakfesgdv katvavlsfi lssaakhsvd geslsselqq lglpkehaas lcrcyeekqs
      121 plqkhlrvcs lrmnrlagvg wrvdytlsss llqsveepmv hlrlevaaap gtpaqpvams
      181 lsadkfqvll aelkqaqtlm sslg
//
LOCUS       XP_011520043             170 aa            linear   PRI 05-AUG-2025
DEFINITION  COMM domain-containing protein 4 isoform X5 [Homo sapiens].
ACCESSION   XP_011520043
VERSION     XP_011520043.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521741.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..170
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..170
                     /product="COMM domain-containing protein 4 isoform X5"
                     /calculated_mol_wt=18197
     Region          55..>157
                     /region_name="Commd"
                     /note="COMM_Domain, a family of domains found at the
                     C-terminus of HCarG, the copper metabolism gene MURR1
                     product, and related proteins. Presumably all COMM_Domain
                     containing proteins are located in the nucleus and the
                     COMM domain plays a role in...; cl06336"
                     /db_xref="CDD:471425"
     CDS             1..170
                     /gene="COMMD4"
                     /coded_by="XM_011521741.3:76..588"
                     /db_xref="GeneID:54939"
                     /db_xref="HGNC:HGNC:26027"
                     /db_xref="MIM:616701"
ORIGIN      
        1 mrgrqvapet gggctglsan tvcagvravs lrfrfcgdld cpdwvlaeis tlakmssvkl
       61 rllcsqvlke llgqgidyek ilkltadakf esgdvkatva vlsfilssaa khsvdgesls
      121 selqqlglpk ehaaslcrcy eekqsplqkh lrvcslrklk qaqtlmsslg
//
LOCUS       XP_016877874             148 aa            linear   PRI 05-AUG-2025
DEFINITION  COMM domain-containing protein 4 isoform X6 [Homo sapiens].
ACCESSION   XP_016877874
VERSION     XP_016877874.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022385.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..148
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..148
                     /product="COMM domain-containing protein 4 isoform X6"
                     /calculated_mol_wt=15815
     Region          56..>135
                     /region_name="Commd"
                     /note="COMM_Domain, a family of domains found at the
                     C-terminus of HCarG, the copper metabolism gene MURR1
                     product, and related proteins. Presumably all COMM_Domain
                     containing proteins are located in the nucleus and the
                     COMM domain plays a role in...; cl06336"
                     /db_xref="CDD:471425"
     CDS             1..148
                     /gene="COMMD4"
                     /coded_by="XM_017022385.2:76..522"
                     /db_xref="GeneID:54939"
                     /db_xref="HGNC:HGNC:26027"
                     /db_xref="MIM:616701"
ORIGIN      
        1 mrgrqvapet gggctglsan tvcagvravs lrfrfcgdld cpdwvlaeis tlakmyekil
       61 kltadakfes gdvkatvavl sfilssaakh svdgeslsse lqqlglpkeh aaslcrcyee
      121 kqsplqkhlr vcslrklkqa qtlmsslg
//
LOCUS       XP_006720652             311 aa            linear   PRI 05-AUG-2025
DEFINITION  protein mono-ADP-ribosyltransferase PARP16 isoform X1 [Homo
            sapiens].
ACCESSION   XP_006720652
VERSION     XP_006720652.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720589.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..311
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..311
                     /product="protein mono-ADP-ribosyltransferase PARP16
                     isoform X1"
                     /calculated_mol_wt=34834
     Region          11..90
                     /region_name="ARTD15_N"
                     /note="ARTD15 N-terminal domain; pfam18084"
                     /db_xref="CDD:465641"
     Region          102..273
                     /region_name="PARP"
                     /note="Poly(ADP-ribose) polymerase catalytic domain;
                     pfam00644"
                     /db_xref="CDD:395519"
     CDS             1..311
                     /gene="PARP16"
                     /gene_synonym="ARTD15; C15orf30; pART15"
                     /coded_by="XM_006720589.4:458..1393"
                     /db_xref="GeneID:54956"
                     /db_xref="HGNC:HGNC:26040"
                     /db_xref="MIM:620391"
ORIGIN      
        1 mqpsgwaaar eaagrdmlaa dlrcslfasa lqsykrdsvl rpfpasyarg dckdfealla
       61 dasklpnlke llqssgdnhk rawdlvswil sskvltihsa gkaefekiqk ltgaphtpvp
      121 apdflfeiey fdpanakfye tkgerdliya fhgsrlenfh siihnglhch lnktslfgeg
      181 tyltsdlsla liysphghgw qhsllgpils cvavcevidh pdvkcqtkkk dskeidrrra
      241 rikhseggdi ppkyfvvtnn qllrvkyllv ysqkppksra ssqlswfssh wftvmislyl
      301 llllidppam l
//
LOCUS       XP_006720653             310 aa            linear   PRI 05-AUG-2025
DEFINITION  protein mono-ADP-ribosyltransferase PARP16 isoform X2 [Homo
            sapiens].
ACCESSION   XP_006720653
VERSION     XP_006720653.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720590.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..310
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..310
                     /product="protein mono-ADP-ribosyltransferase PARP16
                     isoform X2"
                     /calculated_mol_wt=34747
     Region          11..90
                     /region_name="ARTD15_N"
                     /note="ARTD15 N-terminal domain; pfam18084"
                     /db_xref="CDD:465641"
     Region          102..273
                     /region_name="PARP"
                     /note="Poly(ADP-ribose) polymerase catalytic domain;
                     pfam00644"
                     /db_xref="CDD:395519"
     CDS             1..310
                     /gene="PARP16"
                     /gene_synonym="ARTD15; C15orf30; pART15"
                     /coded_by="XM_006720590.4:458..1390"
                     /db_xref="GeneID:54956"
                     /db_xref="HGNC:HGNC:26040"
                     /db_xref="MIM:620391"
ORIGIN      
        1 mqpsgwaaar eaagrdmlaa dlrcslfasa lqsykrdsvl rpfpasyarg dckdfealla
       61 dasklpnlke llqssgdnhk rawdlvswil sskvltihsa gkaefekiqk ltgaphtpvp
      121 apdflfeiey fdpanakfye tkgerdliya fhgsrlenfh siihnglhch lnktslfgeg
      181 tyltsdlsla liysphghgw qhsllgpils cvavcevidh pdvkcqtkkk dskeidrrra
      241 rikhseggdi ppkyfvvtnn qllrvkyllv ysqkppkras sqlswfsshw ftvmislyll
      301 lllidppaml
//
LOCUS       XP_047288731             309 aa            linear   PRI 05-AUG-2025
DEFINITION  protein mono-ADP-ribosyltransferase PARP16 isoform X3 [Homo
            sapiens].
ACCESSION   XP_047288731
VERSION     XP_047288731.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432775.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..309
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..309
                     /product="protein mono-ADP-ribosyltransferase PARP16
                     isoform X3"
                     /calculated_mol_wt=34564
     Region          11..90
                     /region_name="ARTD15_N"
                     /note="ARTD15 N-terminal domain; pfam18084"
                     /db_xref="CDD:465641"
     Region          102..273
                     /region_name="PARP"
                     /note="Poly(ADP-ribose) polymerase catalytic domain;
                     pfam00644"
                     /db_xref="CDD:395519"
     CDS             1..309
                     /gene="PARP16"
                     /gene_synonym="ARTD15; C15orf30; pART15"
                     /coded_by="XM_047432775.1:458..1387"
                     /db_xref="GeneID:54956"
                     /db_xref="HGNC:HGNC:26040"
                     /db_xref="MIM:620391"
ORIGIN      
        1 mqpsgwaaar eaagrdmlaa dlrcslfasa lqsykrdsvl rpfpasyarg dckdfealla
       61 dasklpnlke llqssgdnhk rawdlvswil sskvltihsa gkaefekiqk ltgaphtpvp
      121 apdflfeiey fdpanakfye tkgerdliya fhgsrlenfh siihnglhch lnktslfgeg
      181 tyltsdlsla liysphghgw qhsllgpils cvavcevidh pdvkcqtkkk dskeidrrra
      241 rikhseggdi ppkyfvvtnn qllrvkyllv ysqkppksra ssqlswfssh wftvmislyl
      301 llllialgi
//
LOCUS       XP_047288732             308 aa            linear   PRI 05-AUG-2025
DEFINITION  protein mono-ADP-ribosyltransferase PARP16 isoform X4 [Homo
            sapiens].
ACCESSION   XP_047288732
VERSION     XP_047288732.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432776.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..308
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..308
                     /product="protein mono-ADP-ribosyltransferase PARP16
                     isoform X4"
                     /calculated_mol_wt=34477
     Region          11..90
                     /region_name="ARTD15_N"
                     /note="ARTD15 N-terminal domain; pfam18084"
                     /db_xref="CDD:465641"
     Region          102..273
                     /region_name="PARP"
                     /note="Poly(ADP-ribose) polymerase catalytic domain;
                     pfam00644"
                     /db_xref="CDD:395519"
     CDS             1..308
                     /gene="PARP16"
                     /gene_synonym="ARTD15; C15orf30; pART15"
                     /coded_by="XM_047432776.1:458..1384"
                     /db_xref="GeneID:54956"
                     /db_xref="HGNC:HGNC:26040"
                     /db_xref="MIM:620391"
ORIGIN      
        1 mqpsgwaaar eaagrdmlaa dlrcslfasa lqsykrdsvl rpfpasyarg dckdfealla
       61 dasklpnlke llqssgdnhk rawdlvswil sskvltihsa gkaefekiqk ltgaphtpvp
      121 apdflfeiey fdpanakfye tkgerdliya fhgsrlenfh siihnglhch lnktslfgeg
      181 tyltsdlsla liysphghgw qhsllgpils cvavcevidh pdvkcqtkkk dskeidrrra
      241 rikhseggdi ppkyfvvtnn qllrvkyllv ysqkppkras sqlswfsshw ftvmislyll
      301 lllialgi
//
LOCUS       XP_006720655             304 aa            linear   PRI 05-AUG-2025
DEFINITION  protein mono-ADP-ribosyltransferase PARP16 isoform X5 [Homo
            sapiens].
ACCESSION   XP_006720655
VERSION     XP_006720655.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720592.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..304
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..304
                     /product="protein mono-ADP-ribosyltransferase PARP16
                     isoform X5"
                     /calculated_mol_wt=34330
     Region          11..85
                     /region_name="ARTD15_N"
                     /note="ARTD15 N-terminal domain; pfam18084"
                     /db_xref="CDD:465641"
     Region          84..254
                     /region_name="PARP"
                     /note="Poly(ADP-ribose) polymerase catalytic domain;
                     pfam00644"
                     /db_xref="CDD:395519"
     CDS             1..304
                     /gene="PARP16"
                     /gene_synonym="ARTD15; C15orf30; pART15"
                     /coded_by="XM_006720592.4:458..1372"
                     /db_xref="GeneID:54956"
                     /db_xref="HGNC:HGNC:26040"
                     /db_xref="MIM:620391"
ORIGIN      
        1 mqpsgwaaar eaagrdmlaa dlrcslfasa lqsykrdsvl rpfpasyarg dckdfealla
       61 dasklpnlke llqssgdnhk rawdlfekiq kltgaphtpv papdflfeie yfdpanakfy
      121 etkgerdliy afhgsrlenf hsiihnglhc hlnktslfge gtyltsdlsl aliysphghg
      181 wqhsllgpil scvavcevid hpdvkcqtkk kdskeidrrr arikhseggd ippkyfvvtn
      241 nqllrvkyll vysqkppksr assqlswfss hwftvmisly lllllivsvi nssafqhfwn
      301 rakr
//
LOCUS       XP_016877875             303 aa            linear   PRI 05-AUG-2025
DEFINITION  protein mono-ADP-ribosyltransferase PARP16 isoform X6 [Homo
            sapiens].
ACCESSION   XP_016877875
VERSION     XP_016877875.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022386.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..303
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..303
                     /product="protein mono-ADP-ribosyltransferase PARP16
                     isoform X6"
                     /calculated_mol_wt=34243
     Region          11..85
                     /region_name="ARTD15_N"
                     /note="ARTD15 N-terminal domain; pfam18084"
                     /db_xref="CDD:465641"
     Region          84..254
                     /region_name="PARP"
                     /note="Poly(ADP-ribose) polymerase catalytic domain;
                     pfam00644"
                     /db_xref="CDD:395519"
     CDS             1..303
                     /gene="PARP16"
                     /gene_synonym="ARTD15; C15orf30; pART15"
                     /coded_by="XM_017022386.3:458..1369"
                     /db_xref="GeneID:54956"
                     /db_xref="HGNC:HGNC:26040"
                     /db_xref="MIM:620391"
ORIGIN      
        1 mqpsgwaaar eaagrdmlaa dlrcslfasa lqsykrdsvl rpfpasyarg dckdfealla
       61 dasklpnlke llqssgdnhk rawdlfekiq kltgaphtpv papdflfeie yfdpanakfy
      121 etkgerdliy afhgsrlenf hsiihnglhc hlnktslfge gtyltsdlsl aliysphghg
      181 wqhsllgpil scvavcevid hpdvkcqtkk kdskeidrrr arikhseggd ippkyfvvtn
      241 nqllrvkyll vysqkppkra ssqlswfssh wftvmislyl llllivsvin ssafqhfwnr
      301 akr
//
LOCUS       XP_047288733             291 aa            linear   PRI 05-AUG-2025
DEFINITION  protein mono-ADP-ribosyltransferase PARP16 isoform X7 [Homo
            sapiens].
ACCESSION   XP_047288733
VERSION     XP_047288733.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432777.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..291
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..291
                     /product="protein mono-ADP-ribosyltransferase PARP16
                     isoform X7"
                     /calculated_mol_wt=32739
     Region          11..85
                     /region_name="ARTD15_N"
                     /note="ARTD15 N-terminal domain; pfam18084"
                     /db_xref="CDD:465641"
     Region          84..254
                     /region_name="PARP"
                     /note="Poly(ADP-ribose) polymerase catalytic domain;
                     pfam00644"
                     /db_xref="CDD:395519"
     CDS             1..291
                     /gene="PARP16"
                     /gene_synonym="ARTD15; C15orf30; pART15"
                     /coded_by="XM_047432777.1:458..1333"
                     /db_xref="GeneID:54956"
                     /db_xref="HGNC:HGNC:26040"
                     /db_xref="MIM:620391"
ORIGIN      
        1 mqpsgwaaar eaagrdmlaa dlrcslfasa lqsykrdsvl rpfpasyarg dckdfealla
       61 dasklpnlke llqssgdnhk rawdlfekiq kltgaphtpv papdflfeie yfdpanakfy
      121 etkgerdliy afhgsrlenf hsiihnglhc hlnktslfge gtyltsdlsl aliysphghg
      181 wqhsllgpil scvavcevid hpdvkcqtkk kdskeidrrr arikhseggd ippkyfvvtn
      241 nqllrvkyll vysqkppkra ssqlswfssh wftvmislyl llllidppam l
//
LOCUS       XP_011520044             277 aa            linear   PRI 05-AUG-2025
DEFINITION  protein mono-ADP-ribosyltransferase PARP16 isoform X8 [Homo
            sapiens].
ACCESSION   XP_011520044
VERSION     XP_011520044.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521742.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..277
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..277
                     /product="protein mono-ADP-ribosyltransferase PARP16
                     isoform X8"
                     /calculated_mol_wt=31328
     Region          11..>65
                     /region_name="ARTD15_N"
                     /note="ARTD15 N-terminal domain; pfam18084"
                     /db_xref="CDD:465641"
     Region          59..227
                     /region_name="PARP"
                     /note="Poly(ADP-ribose) polymerase catalytic domain;
                     pfam00644"
                     /db_xref="CDD:395519"
     CDS             1..277
                     /gene="PARP16"
                     /gene_synonym="ARTD15; C15orf30; pART15"
                     /coded_by="XM_011521742.4:458..1291"
                     /db_xref="GeneID:54956"
                     /db_xref="HGNC:HGNC:26040"
                     /db_xref="MIM:620391"
ORIGIN      
        1 mqpsgwaaar eaagrdmlaa dlrcslfasa lqsykrdsvl rpfpasyarg dckdfealfe
       61 kiqkltgaph tpvpapdflf eieyfdpana kfyetkgerd liyafhgsrl enfhsiihng
      121 lhchlnktsl fgegtyltsd lslaliysph ghgwqhsllg pilscvavce vidhpdvkcq
      181 tkkkdskeid rrrarikhse ggdippkyfv vtnnqllrvk yllvysqkpp ksrassqlsw
      241 fsshwftvmi slyllllliv svinssafqh fwnrakr
//
LOCUS       XP_016877876             276 aa            linear   PRI 05-AUG-2025
DEFINITION  protein mono-ADP-ribosyltransferase PARP16 isoform X9 [Homo
            sapiens].
ACCESSION   XP_016877876
VERSION     XP_016877876.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022387.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..276
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..276
                     /product="protein mono-ADP-ribosyltransferase PARP16
                     isoform X9"
                     /calculated_mol_wt=31241
     Region          11..>65
                     /region_name="ARTD15_N"
                     /note="ARTD15 N-terminal domain; pfam18084"
                     /db_xref="CDD:465641"
     Region          59..227
                     /region_name="PARP"
                     /note="Poly(ADP-ribose) polymerase catalytic domain;
                     pfam00644"
                     /db_xref="CDD:395519"
     CDS             1..276
                     /gene="PARP16"
                     /gene_synonym="ARTD15; C15orf30; pART15"
                     /coded_by="XM_017022387.3:458..1288"
                     /db_xref="GeneID:54956"
                     /db_xref="HGNC:HGNC:26040"
                     /db_xref="MIM:620391"
ORIGIN      
        1 mqpsgwaaar eaagrdmlaa dlrcslfasa lqsykrdsvl rpfpasyarg dckdfealfe
       61 kiqkltgaph tpvpapdflf eieyfdpana kfyetkgerd liyafhgsrl enfhsiihng
      121 lhchlnktsl fgegtyltsd lslaliysph ghgwqhsllg pilscvavce vidhpdvkcq
      181 tkkkdskeid rrrarikhse ggdippkyfv vtnnqllrvk yllvysqkpp krassqlswf
      241 sshwftvmis lylllllivs vinssafqhf wnrakr
//
LOCUS       XP_024305737             263 aa            linear   PRI 05-AUG-2025
DEFINITION  protein mono-ADP-ribosyltransferase PARP16 isoform X10 [Homo
            sapiens].
ACCESSION   XP_024305737
VERSION     XP_024305737.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449969.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..263
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..263
                     /product="protein mono-ADP-ribosyltransferase PARP16
                     isoform X10"
                     /calculated_mol_wt=29553
     Region          11..>65
                     /region_name="ARTD15_N"
                     /note="ARTD15 N-terminal domain; pfam18084"
                     /db_xref="CDD:465641"
     Region          59..227
                     /region_name="PARP"
                     /note="Poly(ADP-ribose) polymerase catalytic domain;
                     pfam00644"
                     /db_xref="CDD:395519"
     CDS             1..263
                     /gene="PARP16"
                     /gene_synonym="ARTD15; C15orf30; pART15"
                     /coded_by="XM_024449969.2:458..1249"
                     /db_xref="GeneID:54956"
                     /db_xref="HGNC:HGNC:26040"
                     /db_xref="MIM:620391"
ORIGIN      
        1 mqpsgwaaar eaagrdmlaa dlrcslfasa lqsykrdsvl rpfpasyarg dckdfealfe
       61 kiqkltgaph tpvpapdflf eieyfdpana kfyetkgerd liyafhgsrl enfhsiihng
      121 lhchlnktsl fgegtyltsd lslaliysph ghgwqhsllg pilscvavce vidhpdvkcq
      181 tkkkdskeid rrrarikhse ggdippkyfv vtnnqllrvk yllvysqkpp ksrassqlsw
      241 fsshwftvmi slylllllia lgi
//
LOCUS       XP_016877877             254 aa            linear   PRI 05-AUG-2025
DEFINITION  protein mono-ADP-ribosyltransferase PARP16 isoform X11 [Homo
            sapiens].
ACCESSION   XP_016877877
VERSION     XP_016877877.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022388.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..254
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..254
                     /product="protein mono-ADP-ribosyltransferase PARP16
                     isoform X11"
                     /calculated_mol_wt=28345
     Region          11..90
                     /region_name="ARTD15_N"
                     /note="ARTD15 N-terminal domain; pfam18084"
                     /db_xref="CDD:465641"
     Region          <107..204
                     /region_name="PARP"
                     /note="Poly(ADP-ribose) polymerase catalytic domain;
                     pfam00644"
                     /db_xref="CDD:395519"
     CDS             1..254
                     /gene="PARP16"
                     /gene_synonym="ARTD15; C15orf30; pART15"
                     /coded_by="XM_017022388.3:458..1222"
                     /db_xref="GeneID:54956"
                     /db_xref="HGNC:HGNC:26040"
                     /db_xref="MIM:620391"
ORIGIN      
        1 mqpsgwaaar eaagrdmlaa dlrcslfasa lqsykrdsvl rpfpasyarg dckdfealla
       61 dasklpnlke llqssgdnhk rawdlvswil sskvltihsa gkaetslfge gtyltsdlsl
      121 aliysphghg wqhsllgpil scvavcevid hpdvkcqtkk kdskeidrrr arikhseggd
      181 ippkyfvvtn nqllrvkyll vysqkppksr assqlswfss hwftvmisly lllllivsvi
      241 nssafqhfwn rakr
//
LOCUS       XP_016877878             253 aa            linear   PRI 05-AUG-2025
DEFINITION  protein mono-ADP-ribosyltransferase PARP16 isoform X12 [Homo
            sapiens].
ACCESSION   XP_016877878
VERSION     XP_016877878.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022389.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..253
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..253
                     /product="protein mono-ADP-ribosyltransferase PARP16
                     isoform X12"
                     /calculated_mol_wt=28258
     Region          11..90
                     /region_name="ARTD15_N"
                     /note="ARTD15 N-terminal domain; pfam18084"
                     /db_xref="CDD:465641"
     Region          <107..204
                     /region_name="PARP"
                     /note="Poly(ADP-ribose) polymerase catalytic domain;
                     pfam00644"
                     /db_xref="CDD:395519"
     CDS             1..253
                     /gene="PARP16"
                     /gene_synonym="ARTD15; C15orf30; pART15"
                     /coded_by="XM_017022389.3:458..1219"
                     /db_xref="GeneID:54956"
                     /db_xref="HGNC:HGNC:26040"
                     /db_xref="MIM:620391"
ORIGIN      
        1 mqpsgwaaar eaagrdmlaa dlrcslfasa lqsykrdsvl rpfpasyarg dckdfealla
       61 dasklpnlke llqssgdnhk rawdlvswil sskvltihsa gkaetslfge gtyltsdlsl
      121 aliysphghg wqhsllgpil scvavcevid hpdvkcqtkk kdskeidrrr arikhseggd
      181 ippkyfvvtn nqllrvkyll vysqkppkra ssqlswfssh wftvmislyl llllivsvin
      241 ssafqhfwnr akr
//
LOCUS       XP_047288734             241 aa            linear   PRI 05-AUG-2025
DEFINITION  protein mono-ADP-ribosyltransferase PARP16 isoform X13 [Homo
            sapiens].
ACCESSION   XP_047288734
VERSION     XP_047288734.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432778.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..241
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..241
                     /product="protein mono-ADP-ribosyltransferase PARP16
                     isoform X13"
                     /calculated_mol_wt=26753
     Region          11..90
                     /region_name="ARTD15_N"
                     /note="ARTD15 N-terminal domain; pfam18084"
                     /db_xref="CDD:465641"
     Region          <107..204
                     /region_name="PARP"
                     /note="Poly(ADP-ribose) polymerase catalytic domain;
                     pfam00644"
                     /db_xref="CDD:395519"
     CDS             1..241
                     /gene="PARP16"
                     /gene_synonym="ARTD15; C15orf30; pART15"
                     /coded_by="XM_047432778.1:458..1183"
                     /db_xref="GeneID:54956"
                     /db_xref="HGNC:HGNC:26040"
                     /db_xref="MIM:620391"
ORIGIN      
        1 mqpsgwaaar eaagrdmlaa dlrcslfasa lqsykrdsvl rpfpasyarg dckdfealla
       61 dasklpnlke llqssgdnhk rawdlvswil sskvltihsa gkaetslfge gtyltsdlsl
      121 aliysphghg wqhsllgpil scvavcevid hpdvkcqtkk kdskeidrrr arikhseggd
      181 ippkyfvvtn nqllrvkyll vysqkppkra ssqlswfssh wftvmislyl llllidppam
      241 l
//
LOCUS       XP_024305738             239 aa            linear   PRI 05-AUG-2025
DEFINITION  protein mono-ADP-ribosyltransferase PARP16 isoform X14 [Homo
            sapiens].
ACCESSION   XP_024305738
VERSION     XP_024305738.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449970.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..239
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..239
                     /product="protein mono-ADP-ribosyltransferase PARP16
                     isoform X14"
                     /calculated_mol_wt=26483
     Region          11..90
                     /region_name="ARTD15_N"
                     /note="ARTD15 N-terminal domain; pfam18084"
                     /db_xref="CDD:465641"
     Region          <107..204
                     /region_name="PARP"
                     /note="Poly(ADP-ribose) polymerase catalytic domain;
                     pfam00644"
                     /db_xref="CDD:395519"
     CDS             1..239
                     /gene="PARP16"
                     /gene_synonym="ARTD15; C15orf30; pART15"
                     /coded_by="XM_024449970.2:458..1177"
                     /db_xref="GeneID:54956"
                     /db_xref="HGNC:HGNC:26040"
                     /db_xref="MIM:620391"
ORIGIN      
        1 mqpsgwaaar eaagrdmlaa dlrcslfasa lqsykrdsvl rpfpasyarg dckdfealla
       61 dasklpnlke llqssgdnhk rawdlvswil sskvltihsa gkaetslfge gtyltsdlsl
      121 aliysphghg wqhsllgpil scvavcevid hpdvkcqtkk kdskeidrrr arikhseggd
      181 ippkyfvvtn nqllrvkyll vysqkppkra ssqlswfssh wftvmislyl llllialgi
//
LOCUS       XP_016877879             301 aa            linear   PRI 05-AUG-2025
DEFINITION  TIMELESS-interacting protein isoform X1 [Homo sapiens].
ACCESSION   XP_016877879
VERSION     XP_016877879.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022390.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..301
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..301
                     /product="TIMELESS-interacting protein isoform X1"
                     /calculated_mol_wt=34424
     Region          66..148
                     /region_name="Swi3"
                     /note="Replication Fork Protection Component Swi3;
                     pfam07962"
                     /db_xref="CDD:462324"
     CDS             1..301
                     /gene="TIPIN"
                     /coded_by="XM_017022390.2:154..1059"
                     /db_xref="GeneID:54962"
                     /db_xref="HGNC:HGNC:30750"
                     /db_xref="MIM:610716"
ORIGIN      
        1 mlepqengvi dlpdyehved etfppfpppa sperqdgegt epdeesgnga pvrvppkrtv
       61 krnipkldaq rliserglpa lrhvfdkakf kgkgheaedl kmlirhmehw ahrlfpklqf
      121 edfidrveyl gskkevqtcl krirldlpil hedfvsnnde vaennehdvt steldpfltn
      181 lsesemfase lsrslteeqq qriernkqla lerrqaklls nsqtlgndml mntprahtve
      241 evntdedqke esnglnedil dnpcndaian tlneeetlld qsfknvqqql datsrnitea
      301 r
//
LOCUS       XP_024305739             301 aa            linear   PRI 05-AUG-2025
DEFINITION  TIMELESS-interacting protein isoform X1 [Homo sapiens].
ACCESSION   XP_024305739
VERSION     XP_024305739.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449971.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..301
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..301
                     /product="TIMELESS-interacting protein isoform X1"
                     /calculated_mol_wt=34424
     Region          66..148
                     /region_name="Swi3"
                     /note="Replication Fork Protection Component Swi3;
                     pfam07962"
                     /db_xref="CDD:462324"
     CDS             1..301
                     /gene="TIPIN"
                     /coded_by="XM_024449971.2:214..1119"
                     /db_xref="GeneID:54962"
                     /db_xref="HGNC:HGNC:30750"
                     /db_xref="MIM:610716"
ORIGIN      
        1 mlepqengvi dlpdyehved etfppfpppa sperqdgegt epdeesgnga pvrvppkrtv
       61 krnipkldaq rliserglpa lrhvfdkakf kgkgheaedl kmlirhmehw ahrlfpklqf
      121 edfidrveyl gskkevqtcl krirldlpil hedfvsnnde vaennehdvt steldpfltn
      181 lsesemfase lsrslteeqq qriernkqla lerrqaklls nsqtlgndml mntprahtve
      241 evntdedqke esnglnedil dnpcndaian tlneeetlld qsfknvqqql datsrnitea
      301 r
//
LOCUS       XP_047288735             200 aa            linear   PRI 05-AUG-2025
DEFINITION  TIMELESS-interacting protein isoform X2 [Homo sapiens].
ACCESSION   XP_047288735
VERSION     XP_047288735.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432779.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..200
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..200
                     /product="TIMELESS-interacting protein isoform X2"
                     /calculated_mol_wt=23152
     Region          <2..47
                     /region_name="Swi3"
                     /note="Replication Fork Protection Component Swi3;
                     pfam07962"
                     /db_xref="CDD:462324"
     CDS             1..200
                     /gene="TIPIN"
                     /coded_by="XM_047432779.1:97..699"
                     /db_xref="GeneID:54962"
                     /db_xref="HGNC:HGNC:30750"
                     /db_xref="MIM:610716"
ORIGIN      
        1 mlirhmehwa hrlfpklqfe dfidrveylg skkevqtclk rirldlpilh edfvsnndev
       61 aennehdvts teldpfltnl sesemfasel srslteeqqq riernkqlal errqakllsn
      121 sqtlgndmlm ntprahtvee vntdedqkee snglnedild npcndaiant lneeetlldq
      181 sfknvqqqld atsrnitear
//
LOCUS       XP_011520046             691 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 770 isoform X1 [Homo sapiens].
ACCESSION   XP_011520046
VERSION     XP_011520046.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521744.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..691
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..691
                     /product="zinc finger protein 770 isoform X1"
                     /calculated_mol_wt=79876
     Region          29..49
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(34,36,38,40..41,44..45,48,62,64,68..69,72..73,76,88,
                     90,92,94..95,98..99,102)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          42..66
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          57..77
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          83..103
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          162..182
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(167,169,171,173..174,177..178,181,195,197,201..202,
                     205..206,209,223,225,227,229..230,233..234,237)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          185..530
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          190..210
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          218..238
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          477..497
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(482,484,486,488..489,492..493,496,510,512,516..517,
                     520..521,524,537,539,541,543..544,547..548)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          505..525
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          627..647
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          640..664
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          655..675
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..691
                     /gene="ZNF770"
                     /gene_synonym="PRO1914"
                     /coded_by="XM_011521744.4:229..2304"
                     /db_xref="GeneID:54989"
                     /db_xref="HGNC:HGNC:26061"
ORIGIN      
        1 mmaennlkml kiqqcvvank lprnrpyvcn icfkhfetps klarhyliht gqkpfecdvc
       61 hktfrqlvhl erhqlthslp fkcsicqrhf knlktfvkhq qlhnetyqnn vkqvrrllea
      121 kqeksmygvy ntftteerwa lhpcsksdpm ysmkrrknih acticgkmfp sqskldrhvl
      181 ihtgqrpfkc vlctksfrqs thlkihqlth seerpfqccf cqkgfkiqsk llkhkqihtr
      241 nkafralllk krrtesrplp nklnanqggf engeigesee nnpldvhsiy ivpfqcpkce
      301 kcfeseqiln ehscfaarsg kipsrfkrsy nyktivkkil aklkrarskk ldnfqsekkv
      361 fkksflrncd lisgeqsseq tqrtfvgslg khgtyktign rkkktltlpf swqnmgknlk
      421 gilttenils idnsvnkkdl sicgssgeef fnncevlqcg fsvprenirt rhkicpcdkc
      481 ekvfpsiskl krhylihtgq rpfgcnicgk sfrqsahlkr heqthneksp yaslcqvefg
      541 nfnnlsnhsg nnvnynasqq cqapgvqkye vsesdqmsgv kaesqdfipg stgqpclpnv
      601 lleseqsnpf csysehqekn dvflyrcsvc aksfrspskl erhylihagq kpfecsvcgk
      661 tfrqaphwkr hqlthfkerp qgkvvaldsv m
//
LOCUS       XP_024305743             614 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger and SCAN domain-containing protein 2 isoform X1 [Homo
            sapiens].
ACCESSION   XP_024305743
VERSION     XP_024305743.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449975.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..614
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..614
                     /product="zinc finger and SCAN domain-containing protein 2
                     isoform X1"
                     /calculated_mol_wt=69417
     Region          72..134
                     /region_name="SCAN"
                     /note="SCAN domain; pfam02023"
                     /db_xref="CDD:460417"
     Region          220..600
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          224..244
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          252..272
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(257,259,261,263..264,267..268,271,285,287,291..292,
                     295..296,299,313,315,317,319..320,323..324,327)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          280..300
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          308..328
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          336..356
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          364..384
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(369,371,373,375..376,379..380,383,397,399,403..404,
                     407..408,411,425,427,429,431..432,435..436,439)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          392..412
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          420..440
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          448..468
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(453,455,457,459..460,463..464,467,481,483,487..488,
                     491..492,495,509,511,513,515..516,519..520,523)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          476..496
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          504..524
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          532..552
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(537,539,541,543..544,547..548,551,565,567,571..572,
                     575..576,579,593,595,597,599..600,603..604,607)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          560..580
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          588..608
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..614
                     /gene="ZSCAN2"
                     /gene_synonym="ZFP29; ZNF854"
                     /coded_by="XM_024449975.2:289..2133"
                     /db_xref="GeneID:54993"
                     /db_xref="HGNC:HGNC:20994"
ORIGIN      
        1 mmaadiprvt tplsslvqvp qeedrqeeev ttmileddsw vqeavlqedg pesepfpqsa
       61 gkggpqeevt rgpqgalgrl relcrrwlrp evhtkeqmlt mlpkeiqawl qehrpessee
      121 aaalvedltq tlqdsdfeiq sengencnqd mfenesrkif sempegesaq hsdgesdfer
      181 dagiqrlqgh spgedhgevv sqdrevgqli glqgtylgek pyecpqcgkt fsrkshlith
      241 erthtgekyy kcdecgksfs dgsnfsrhqt thtgekpykc rdcgksfsrs anlithqrih
      301 tgekpfqcae cgksfsrspn liahqrthtg ekpyscpecg ksfgnrssln thqgihtgek
      361 pyeckecges fsynsnlirh qrihtgekpy kctdcgqrfs qssalithrr thtgekpyqc
      421 secgksfsrs snlathrrth mvekpykcgv cgksfsqsss liahqgmhtg ekpyecltcg
      481 esfswssnll khqrihtgek pykcsecgkc fsqrsqlvvh qrthtgekpy kclmcgksfs
      541 rgsilvmhqr ahlgdkpyrc pecgkgfswn svliihqrih tgekpykcpe cgkgfsnssn
      601 fithqrthmk ekly
//
LOCUS       XP_047288737             614 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger and SCAN domain-containing protein 2 isoform X1 [Homo
            sapiens].
ACCESSION   XP_047288737
VERSION     XP_047288737.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432781.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..614
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..614
                     /product="zinc finger and SCAN domain-containing protein 2
                     isoform X1"
                     /calculated_mol_wt=69417
     Region          72..134
                     /region_name="SCAN"
                     /note="SCAN domain; pfam02023"
                     /db_xref="CDD:460417"
     Region          220..600
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          224..244
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          252..272
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(257,259,261,263..264,267..268,271,285,287,291..292,
                     295..296,299,313,315,317,319..320,323..324,327)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          280..300
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          308..328
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          336..356
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          364..384
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(369,371,373,375..376,379..380,383,397,399,403..404,
                     407..408,411,425,427,429,431..432,435..436,439)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          392..412
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          420..440
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          448..468
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(453,455,457,459..460,463..464,467,481,483,487..488,
                     491..492,495,509,511,513,515..516,519..520,523)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          476..496
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          504..524
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          532..552
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(537,539,541,543..544,547..548,551,565,567,571..572,
                     575..576,579,593,595,597,599..600,603..604,607)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          560..580
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          588..608
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..614
                     /gene="ZSCAN2"
                     /gene_synonym="ZFP29; ZNF854"
                     /coded_by="XM_047432781.1:616..2460"
                     /db_xref="GeneID:54993"
                     /db_xref="HGNC:HGNC:20994"
ORIGIN      
        1 mmaadiprvt tplsslvqvp qeedrqeeev ttmileddsw vqeavlqedg pesepfpqsa
       61 gkggpqeevt rgpqgalgrl relcrrwlrp evhtkeqmlt mlpkeiqawl qehrpessee
      121 aaalvedltq tlqdsdfeiq sengencnqd mfenesrkif sempegesaq hsdgesdfer
      181 dagiqrlqgh spgedhgevv sqdrevgqli glqgtylgek pyecpqcgkt fsrkshlith
      241 erthtgekyy kcdecgksfs dgsnfsrhqt thtgekpykc rdcgksfsrs anlithqrih
      301 tgekpfqcae cgksfsrspn liahqrthtg ekpyscpecg ksfgnrssln thqgihtgek
      361 pyeckecges fsynsnlirh qrihtgekpy kctdcgqrfs qssalithrr thtgekpyqc
      421 secgksfsrs snlathrrth mvekpykcgv cgksfsqsss liahqgmhtg ekpyecltcg
      481 esfswssnll khqrihtgek pykcsecgkc fsqrsqlvvh qrthtgekpy kclmcgksfs
      541 rgsilvmhqr ahlgdkpyrc pecgkgfswn svliihqrih tgekpykcpe cgkgfsnssn
      601 fithqrthmk ekly
//
LOCUS       XP_024305744             464 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger and SCAN domain-containing protein 2 isoform X2 [Homo
            sapiens].
ACCESSION   XP_024305744
VERSION     XP_024305744.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449976.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..464
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..464
                     /product="zinc finger and SCAN domain-containing protein 2
                     isoform X2"
                     /calculated_mol_wt=52451
     Region          70..450
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          74..94
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          102..122
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(107,109,111,113..114,117..118,121,135,137,141..142,
                     145..146,149,163,165,167,169..170,173..174,177)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          130..150
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(130,133,146,150)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:275368"
     Region          158..178
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          186..206
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          214..234
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(219,221,223,225..226,229..230,233,247,249,253..254,
                     257..258,261,275,277,279,281..282,285..286,289)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          242..262
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(242,245,258,262)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:275368"
     Region          270..290
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          298..318
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(303,305,307,309..310,313..314,317,331,333,337..338,
                     341..342,345,359,361,363,365..366,369..370,373)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          326..346
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(326,329,342,346)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:275368"
     Region          354..374
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          382..402
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(387,389,391,393..394,397..398,401,415,417,421..422,
                     425..426,429,443,445,447,449..450,453..454,457)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          410..430
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(410,413,426,430)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:275368"
     Region          438..458
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..464
                     /gene="ZSCAN2"
                     /gene_synonym="ZFP29; ZNF854"
                     /coded_by="XM_024449976.2:104..1498"
                     /db_xref="GeneID:54993"
                     /db_xref="HGNC:HGNC:20994"
ORIGIN      
        1 mfenesrkif sempegesaq hsdgesdfer dagiqrlqgh spgedhgevv sqdrevgqli
       61 glqgtylgek pyecpqcgkt fsrkshlith erthtgekyy kcdecgksfs dgsnfsrhqt
      121 thtgekpykc rdcgksfsrs anlithqrih tgekpfqcae cgksfsrspn liahqrthtg
      181 ekpyscpecg ksfgnrssln thqgihtgek pyeckecges fsynsnlirh qrihtgekpy
      241 kctdcgqrfs qssalithrr thtgekpyqc secgksfsrs snlathrrth mvekpykcgv
      301 cgksfsqsss liahqgmhtg ekpyecltcg esfswssnll khqrihtgek pykcsecgkc
      361 fsqrsqlvvh qrthtgekpy kclmcgksfs rgsilvmhqr ahlgdkpyrc pecgkgfswn
      421 svliihqrih tgekpykcpe cgkgfsnssn fithqrthmk ekly
//
LOCUS       XP_047288738             181 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger and SCAN domain-containing protein 2 isoform X3 [Homo
            sapiens].
ACCESSION   XP_047288738
VERSION     XP_047288738.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432782.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..181
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..181
                     /product="zinc finger and SCAN domain-containing protein 2
                     isoform X3"
                     /calculated_mol_wt=20041
     Region          72..134
                     /region_name="SCAN"
                     /note="SCAN domain; pfam02023"
                     /db_xref="CDD:460417"
     CDS             1..181
                     /gene="ZSCAN2"
                     /gene_synonym="ZFP29; ZNF854"
                     /coded_by="XM_047432782.1:236..781"
                     /db_xref="GeneID:54993"
                     /db_xref="HGNC:HGNC:20994"
ORIGIN      
        1 mmaadiprvt tplsslvqvp qeedrqeeev ttmileddsw vqeavlqedg pesepfpqsa
       61 gkggpqeevt rgpqgalgrl relcrrwlrp evhtkeqmlt mlpkeiqawl qehrpessee
      121 aaalvedltq tlqdsgsqrv hqpfsvltvc kvssrsarra lelhlnsvav vaslpvevts
      181 l
//
LOCUS       XP_016877882             166 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger and SCAN domain-containing protein 2 isoform X4 [Homo
            sapiens].
ACCESSION   XP_016877882
VERSION     XP_016877882.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022393.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..166
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..166
                     /product="zinc finger and SCAN domain-containing protein 2
                     isoform X4"
                     /calculated_mol_wt=18588
     Region          72..134
                     /region_name="SCAN"
                     /note="SCAN domain; pfam02023"
                     /db_xref="CDD:460417"
     CDS             1..166
                     /gene="ZSCAN2"
                     /gene_synonym="ZFP29; ZNF854"
                     /coded_by="XM_017022393.3:236..736"
                     /db_xref="GeneID:54993"
                     /db_xref="HGNC:HGNC:20994"
ORIGIN      
        1 mmaadiprvt tplsslvqvp qeedrqeeev ttmileddsw vqeavlqedg pesepfpqsa
       61 gkggpqeevt rgpqgalgrl relcrrwlrp evhtkeqmlt mlpkeiqawl qehrpessee
      121 aaalvedltq tlqdsgsqrv hqpfsvltvc kvssrsarra lelhln
//
LOCUS       XP_024305746             645 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger and SCAN domain-containing protein 2 isoform X5 [Homo
            sapiens].
ACCESSION   XP_024305746
VERSION     XP_024305746.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449978.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..645
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..645
                     /product="zinc finger and SCAN domain-containing protein 2
                     isoform X5"
                     /calculated_mol_wt=72924
     Region          70..157
                     /region_name="SCAN"
                     /note="leucine rich region; smart00431"
                     /db_xref="CDD:128708"
     Region          251..631
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          255..275
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          283..303
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(288,290,292,294..295,298..299,302,316,318,322..323,
                     326..327,330,344,346,348,350..351,354..355,358)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          311..331
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          339..359
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          367..387
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          395..415
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(400,402,404,406..407,410..411,414,428,430,434..435,
                     438..439,442,456,458,460,462..463,466..467,470)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          423..443
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          451..471
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          479..499
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(484,486,488,490..491,494..495,498,512,514,518..519,
                     522..523,526,540,542,544,546..547,550..551,554)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          507..527
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          535..555
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          563..583
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(568,570,572,574..575,578..579,582,596,598,602..603,
                     606..607,610,624,626,628,630..631,634..635,638)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          591..611
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          619..639
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..645
                     /gene="ZSCAN2"
                     /gene_synonym="ZFP29; ZNF854"
                     /coded_by="XM_024449978.2:236..2173"
                     /db_xref="GeneID:54993"
                     /db_xref="HGNC:HGNC:20994"
ORIGIN      
        1 mmaadiprvt tplsslvqvp qeedrqeeev ttmileddsw vqeavlqedg pesepfpqsa
       61 gkggpqeevt rgpqgalgrl relcrrwlrp evhtkeqmlt mlpkeiqawl qehrpessee
      121 aaalvedltq tlqdsgsqrv hqpfsvltvc kvssrsarra lelhlnyfei qsengencnq
      181 dmfenesrki fsempegesa qhsdgesdfe rdagiqrlqg hspgedhgev vsqdrevgql
      241 iglqgtylge kpyecpqcgk tfsrkshlit herthtgeky ykcdecgksf sdgsnfsrhq
      301 tthtgekpyk crdcgksfsr sanlithqri htgekpfqca ecgksfsrsp nliahqrtht
      361 gekpyscpec gksfgnrssl nthqgihtge kpyeckecge sfsynsnlir hqrihtgekp
      421 ykctdcgqrf sqssalithr rthtgekpyq csecgksfsr ssnlathrrt hmvekpykcg
      481 vcgksfsqss sliahqgmht gekpyecltc gesfswssnl lkhqrihtge kpykcsecgk
      541 cfsqrsqlvv hqrthtgekp ykclmcgksf srgsilvmhq rahlgdkpyr cpecgkgfsw
      601 nsvliihqri htgekpykcp ecgkgfsnss nfithqrthm kekly
//
LOCUS       XP_011520054            1436 aa            linear   PRI 05-AUG-2025
DEFINITION  uveal autoantigen with coiled-coil domains and ankyrin repeats
            isoform X1 [Homo sapiens].
ACCESSION   XP_011520054
VERSION     XP_011520054.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521752.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Jun 6, 2016 this sequence version replaced XP_011520054.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1436
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1436
                     /product="uveal autoantigen with coiled-coil domains and
                     ankyrin repeats isoform X1"
                     /calculated_mol_wt=164867
     Region          21..289
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          58..85
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          87..118
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          121..151
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          154..184
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(155,159..160,163..165,167..168,172,175,184,186,188,
                     192..193,196..198,200..201,205,208,217,219,221,225..226,
                     229..231,233..234,238,241,250)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          186..217
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          219..250
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          271..>623
                     /region_name="PLN02939"
                     /note="transferase, transferring glycosyl groups"
                     /db_xref="CDD:215507"
     Region          565..1366
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1436
                     /gene="UACA"
                     /gene_synonym="NUCLING"
                     /coded_by="XM_011521752.4:376..4686"
                     /db_xref="GeneID:55075"
                     /db_xref="HGNC:HGNC:15947"
                     /db_xref="MIM:612516"
ORIGIN      
        1 mlslksiiln vsciscvlgr fynsallmkl aqkgegnlec nwkisdhaad wnkyddrlmk
       61 aaergdvekv tsilakkgvn pgkldvegrs vfhvvtskgn leclnailih gvdittsdta
      121 grnalhlaak yghalclqkl lqyncpteha dlqgrtalhd aamadcpssi qllcdhgasv
      181 nakdvdgrtp lvlatqmsrp ticqllidrg advnsrdkqn rtalmlgcey gcrdavevli
      241 kngadislld alghdssyya rigdnldilt llktasentn kgrelwkkgp slqqrnlthm
      301 qdevnvkshq rehqniqdle ienedlkerl rkiqqeqril ldkvnglqlq lneevmvadd
      361 lesereklks llaakekqhe eslrtiealk nrfkyfesdh lgsgshfsnr kedmllkqgq
      421 mymadsqcts pgipahmqsr smlrplelsl psqtsysene ilkkeleamr tfcesakqdr
      481 lklqnelahk vaeckalale cervkedsde qikqledalk dvqkrmyese gkvkqmqthf
      541 lalkehltse aasgnhrlte elkdqlkdlk vkyegasaev gklrnqikqn emiveefkrd
      601 egklieenkr lqkelsmcem erekkgrkvt emegqakels aklalsipae kfenmkssls
      661 nevnekakkl vemereheks lseirqlkre lenvkaklaq hvkpeeheqv ksrleqksge
      721 lgkkiteltl knqtlqkeie kvyldnkllk eqahnltiem knhyvplkvs edmkkshdai
      781 iddlnrklld vtqkytekkl emeklllend slskdvsrle tvfvppekhe keiialksni
      841 velkkqlsel kkkcgedqek ihaltsentn lkkmmsnqyv pvktheevkm tlndtlaktn
      901 relldvkkkf edinqefvki kdkneilkrn lentqnqika eyislaehea kmsslsqsmr
      961 kvqdsnaeil anyrkgqeei vtlhaeikaq kkeldtiqec ikvkyapivs feecerkfka
     1021 tekelkdqls eqtqkysvse eevkknkqen dklkkeiftl qkdlrdktvl iekshemera
     1081 lsrktdelnk qlkdlsqkyt evknvkeklv eenakqtsei lavqnllqkq hvpleqveal
     1141 kkslngtien lkeelksmqr cyekeqqtvt klhqllenqk nssvplaehl qikeafekev
     1201 giikaslrek eeesqnkmee vsklqsevqn tkqalkklet revvdlskyk atksdletqi
     1261 sslneklanl nrkyeevcee vlhakkkeis akdekellhf sieqeikdqk ercdksltti
     1321 telqrriqes akqieakdnk itellndver lkqalnglsq ltytsgnptk rqsqlidtlq
     1381 hqvksleqql adadrqhqev iaiyrthlls aaqghmdedv qeallqiiqm rqglvc
//
LOCUS       XP_011520055            1425 aa            linear   PRI 05-AUG-2025
DEFINITION  uveal autoantigen with coiled-coil domains and ankyrin repeats
            isoform X2 [Homo sapiens].
ACCESSION   XP_011520055
VERSION     XP_011520055.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521753.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Jun 6, 2016 this sequence version replaced XP_011520055.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1425
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1425
                     /product="uveal autoantigen with coiled-coil domains and
                     ankyrin repeats isoform X2"
                     /calculated_mol_wt=163649
     Region          21..289
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          58..85
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          87..118
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          121..151
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          154..184
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(155,159..160,163..165,167..168,172,175,184,186,188,
                     192..193,196..198,200..201,205,208,217,219,221,225..226,
                     229..231,233..234,238,241,250)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          186..217
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          219..250
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          <319..>741
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          554..1355
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1425
                     /gene="UACA"
                     /gene_synonym="NUCLING"
                     /coded_by="XM_011521753.3:376..4653"
                     /db_xref="GeneID:55075"
                     /db_xref="HGNC:HGNC:15947"
                     /db_xref="MIM:612516"
ORIGIN      
        1 mlslksiiln vsciscvlgr fynsallmkl aqkgegnlec nwkisdhaad wnkyddrlmk
       61 aaergdvekv tsilakkgvn pgkldvegrs vfhvvtskgn leclnailih gvdittsdta
      121 grnalhlaak yghalclqkl lqyncpteha dlqgrtalhd aamadcpssi qllcdhgasv
      181 nakdvdgrtp lvlatqmsrp ticqllidrg advnsrdkqn rtalmlgcey gcrdavevli
      241 kngadislld alghdssyya rigdnldilt llktasentn kgrelwkkgp slqqrnlthm
      301 qdevnvkshq rehqniqdle ienedlkerl rkiqqeqril ldkvnglqlq lnereklksl
      361 laakekqhee slrtiealkn rfkyfesdhl gsgshfsnrk edmllkqgqm ymadsqctsp
      421 gipahmqsrs mlrplelslp sqtsysenei lkkeleamrt fcesakqdrl klqnelahkv
      481 aeckalalec ervkedsdeq ikqledalkd vqkrmyeseg kvkqmqthfl alkehltsea
      541 asgnhrltee lkdqlkdlkv kyegasaevg klrnqikqne miveefkrde gklieenkrl
      601 qkelsmceme rekkgrkvte megqakelsa klalsipaek fenmksslsn evnekakklv
      661 emereheksl seirqlkrel envkaklaqh vkpeeheqvk srleqksgel gkkiteltlk
      721 nqtlqkeiek vyldnkllke qahnltiemk nhyvplkvse dmkkshdaii ddlnrklldv
      781 tqkytekkle meklllends lskdvsrlet vfvppekhek eiialksniv elkkqlselk
      841 kkcgedqeki haltsentnl kkmmsnqyvp vktheevkmt lndtlaktnr elldvkkkfe
      901 dinqefvkik dkneilkrnl entqnqikae yislaeheak msslsqsmrk vqdsnaeila
      961 nyrkgqeeiv tlhaeikaqk keldtiqeci kvkyapivsf eecerkfkat ekelkdqlse
     1021 qtqkysvsee evkknkqend klkkeiftlq kdlrdktvli ekshemeral srktdelnkq
     1081 lkdlsqkyte vknvkeklve enakqtseil avqnllqkqh vpleqvealk kslngtienl
     1141 keelksmqrc yekeqqtvtk lhqllenqkn ssvplaehlq ikeafekevg iikaslreke
     1201 eesqnkmeev sklqsevqnt kqalkkletr evvdlskyka tksdletqis slneklanln
     1261 rkyeevceev lhakkkeisa kdekellhfs ieqeikdqke rcdkslttit elqrriqesa
     1321 kqieakdnki tellndverl kqalnglsql tytsgnptkr qsqlidtlqh qvksleqqla
     1381 dadrqhqevi aiyrthllsa aqghmdedvq eallqiiqmr qglvc
//
LOCUS       XP_016877883            1405 aa            linear   PRI 05-AUG-2025
DEFINITION  uveal autoantigen with coiled-coil domains and ankyrin repeats
            isoform X3 [Homo sapiens].
ACCESSION   XP_016877883
VERSION     XP_016877883.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022394.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1405
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1405
                     /product="uveal autoantigen with coiled-coil domains and
                     ankyrin repeats isoform X3"
                     /calculated_mol_wt=161157
     Region          32..269
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          38..65
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          67..98
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          101..131
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          134..164
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(135,139..140,143..145,147..148,152,155,164,166,168,
                     172..173,176..178,180..181,185,188,197,199,201,205..206,
                     209..211,213..214,218,221,230)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          166..197
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          199..230
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          <299..>721
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          534..1335
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1405
                     /gene="UACA"
                     /gene_synonym="NUCLING"
                     /coded_by="XM_017022394.3:152..4369"
                     /db_xref="GeneID:55075"
                     /db_xref="HGNC:HGNC:15947"
                     /db_xref="MIM:612516"
ORIGIN      
        1 mkslksrlrr qdvpgpassg aaaasahaad wnkyddrlmk aaergdvekv tsilakkgvn
       61 pgkldvegrs vfhvvtskgn leclnailih gvdittsdta grnalhlaak yghalclqkl
      121 lqyncpteha dlqgrtalhd aamadcpssi qllcdhgasv nakdvdgrtp lvlatqmsrp
      181 ticqllidrg advnsrdkqn rtalmlgcey gcrdavevli kngadislld alghdssyya
      241 rigdnldilt llktasentn kgrelwkkgp slqqrnlthm qdevnvkshq rehqniqdle
      301 ienedlkerl rkiqqeqril ldkvnglqlq lnereklksl laakekqhee slrtiealkn
      361 rfkyfesdhl gsgshfsnrk edmllkqgqm ymadsqctsp gipahmqsrs mlrplelslp
      421 sqtsysenei lkkeleamrt fcesakqdrl klqnelahkv aeckalalec ervkedsdeq
      481 ikqledalkd vqkrmyeseg kvkqmqthfl alkehltsea asgnhrltee lkdqlkdlkv
      541 kyegasaevg klrnqikqne miveefkrde gklieenkrl qkelsmceme rekkgrkvte
      601 megqakelsa klalsipaek fenmksslsn evnekakklv emereheksl seirqlkrel
      661 envkaklaqh vkpeeheqvk srleqksgel gkkiteltlk nqtlqkeiek vyldnkllke
      721 qahnltiemk nhyvplkvse dmkkshdaii ddlnrklldv tqkytekkle meklllends
      781 lskdvsrlet vfvppekhek eiialksniv elkkqlselk kkcgedqeki haltsentnl
      841 kkmmsnqyvp vktheevkmt lndtlaktnr elldvkkkfe dinqefvkik dkneilkrnl
      901 entqnqikae yislaeheak msslsqsmrk vqdsnaeila nyrkgqeeiv tlhaeikaqk
      961 keldtiqeci kvkyapivsf eecerkfkat ekelkdqlse qtqkysvsee evkknkqend
     1021 klkkeiftlq kdlrdktvli ekshemeral srktdelnkq lkdlsqkyte vknvkeklve
     1081 enakqtseil avqnllqkqh vpleqvealk kslngtienl keelksmqrc yekeqqtvtk
     1141 lhqllenqkn ssvplaehlq ikeafekevg iikaslreke eesqnkmeev sklqsevqnt
     1201 kqalkkletr evvdlskyka tksdletqis slneklanln rkyeevceev lhakkkeisa
     1261 kdekellhfs ieqeikdqke rcdkslttit elqrriqesa kqieakdnki tellndverl
     1321 kqalnglsql tytsgnptkr qsqlidtlqh qvksleqqla dadrqhqevi aiyrthllsa
     1381 aqghmdedvq eallqiiqmr qglvc
//
LOCUS       XP_016877884            1399 aa            linear   PRI 05-AUG-2025
DEFINITION  uveal autoantigen with coiled-coil domains and ankyrin repeats
            isoform X4 [Homo sapiens].
ACCESSION   XP_016877884
VERSION     XP_016877884.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022395.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1399
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1399
                     /product="uveal autoantigen with coiled-coil domains and
                     ankyrin repeats isoform X4"
                     /calculated_mol_wt=160919
     Region          9..252
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          21..48
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          50..81
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          84..114
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          117..147
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(118,122..123,126..128,130..131,135,138,147,149,151,
                     155..156,159..161,163..164,168,171,180,182,184,188..189,
                     192..194,196..197,201,204,213)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          149..180
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          182..213
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          234..>586
                     /region_name="PLN02939"
                     /note="transferase, transferring glycosyl groups"
                     /db_xref="CDD:215507"
     Region          528..1329
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1399
                     /gene="UACA"
                     /gene_synonym="NUCLING"
                     /coded_by="XM_017022395.2:96..4295"
                     /db_xref="GeneID:55075"
                     /db_xref="HGNC:HGNC:15947"
                     /db_xref="MIM:612516"
ORIGIN      
        1 mamrektykh aadwnkyddr lmkaaergdv ekvtsilakk gvnpgkldve grsvfhvvts
       61 kgnleclnai lihgvditts dtagrnalhl aakyghalcl qkllqyncpt ehadlqgrta
      121 lhdaamadcp ssiqllcdhg asvnakdvdg rtplvlatqm srpticqlli drgadvnsrd
      181 kqnrtalmlg ceygcrdave vlikngadis lldalghdss yyarigdnld iltllktase
      241 ntnkgrelwk kgpslqqrnl thmqdevnvk shqrehqniq dleienedlk erlrkiqqeq
      301 rilldkvngl qlqlneevmv addleserek lksllaakek qheeslrtie alknrfkyfe
      361 sdhlgsgshf snrkedmllk qgqmymadsq ctspgipahm qsrsmlrple lslpsqtsys
      421 eneilkkele amrtfcesak qdrlklqnel ahkvaeckal alecervked sdeqikqled
      481 alkdvqkrmy esegkvkqmq thflalkehl tseaasgnhr lteelkdqlk dlkvkyegas
      541 aevgklrnqi kqnemiveef krdegkliee nkrlqkelsm cemerekkgr kvtemegqak
      601 elsaklalsi paekfenmks slsnevneka kklvemereh ekslseirql krelenvkak
      661 laqhvkpeeh eqvksrleqk sgelgkkite ltlknqtlqk eiekvyldnk llkeqahnlt
      721 iemknhyvpl kvsedmkksh daiiddlnrk lldvtqkyte kklemeklll endslskdvs
      781 rletvfvppe khekeiialk snivelkkql selkkkcged qekihaltse ntnlkkmmsn
      841 qyvpvkthee vkmtlndtla ktnrelldvk kkfedinqef vkikdkneil krnlentqnq
      901 ikaeyislae heakmsslsq smrkvqdsna eilanyrkgq eeivtlhaei kaqkkeldti
      961 qecikvkyap ivsfeecerk fkatekelkd qlseqtqkys vseeevkknk qendklkkei
     1021 ftlqkdlrdk tvliekshem eralsrktde lnkqlkdlsq kytevknvke klveenakqt
     1081 seilavqnll qkqhvpleqv ealkkslngt ienlkeelks mqrcyekeqq tvtklhqlle
     1141 nqknssvpla ehlqikeafe kevgiikasl rekeeesqnk meevsklqse vqntkqalkk
     1201 letrevvdls kykatksdle tqisslnekl anlnrkyeev ceevlhakkk eisakdekel
     1261 lhfsieqeik dqkercdksl ttitelqrri qesakqieak dnkitellnd verlkqalng
     1321 lsqltytsgn ptkrqsqlid tlqhqvksle qqladadrqh qeviaiyrth llsaaqghmd
     1381 edvqeallqi iqmrqglvc
//
LOCUS       XP_005254586            1392 aa            linear   PRI 05-AUG-2025
DEFINITION  uveal autoantigen with coiled-coil domains and ankyrin repeats
            isoform X5 [Homo sapiens].
ACCESSION   XP_005254586
VERSION     XP_005254586.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254529.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1392
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1392
                     /product="uveal autoantigen with coiled-coil domains and
                     ankyrin repeats isoform X5"
                     /calculated_mol_wt=160162
     Region          11..256
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          25..52
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          54..85
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          88..118
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          121..151
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(122,126..127,130..132,134..135,139,142,151,153,155,
                     159..160,163..165,167..168,172,175,184,186,188,192..193,
                     196..198,200..201,205,208,217)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          153..184
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          186..217
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          <286..>708
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          521..1322
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1392
                     /gene="UACA"
                     /gene_synonym="NUCLING"
                     /coded_by="XM_005254529.5:368..4546"
                     /db_xref="GeneID:55075"
                     /db_xref="HGNC:HGNC:15947"
                     /db_xref="MIM:612516"
ORIGIN      
        1 mmncwfsctp knrhaadwnk yddrlmkaae rgdvekvtsi lakkgvnpgk ldvegrsvfh
       61 vvtskgnlec lnailihgvd ittsdtagrn alhlaakygh alclqkllqy ncptehadlq
      121 grtalhdaam adcpssiqll cdhgasvnak dvdgrtplvl atqmsrptic qllidrgadv
      181 nsrdkqnrta lmlgceygcr davevlikng adislldalg hdssyyarig dnldiltllk
      241 tasentnkgr elwkkgpslq qrnlthmqde vnvkshqreh qniqdleien edlkerlrki
      301 qqeqrilldk vnglqlqlne reklksllaa kekqheeslr tiealknrfk yfesdhlgsg
      361 shfsnrkedm llkqgqmyma dsqctspgip ahmqsrsmlr plelslpsqt syseneilkk
      421 eleamrtfce sakqdrlklq nelahkvaec kalalecerv kedsdeqikq ledalkdvqk
      481 rmyesegkvk qmqthflalk ehltseaasg nhrlteelkd qlkdlkvkye gasaevgklr
      541 nqikqnemiv eefkrdegkl ieenkrlqke lsmcemerek kgrkvtemeg qakelsakla
      601 lsipaekfen mksslsnevn ekakklveme rehekslsei rqlkrelenv kaklaqhvkp
      661 eeheqvksrl eqksgelgkk iteltlknqt lqkeiekvyl dnkllkeqah nltiemknhy
      721 vplkvsedmk kshdaiiddl nrklldvtqk ytekklemek lllendslsk dvsrletvfv
      781 ppekhekeii alksnivelk kqlselkkkc gedqekihal tsentnlkkm msnqyvpvkt
      841 heevkmtlnd tlaktnrell dvkkkfedin qefvkikdkn eilkrnlent qnqikaeyis
      901 laeheakmss lsqsmrkvqd snaeilanyr kgqeeivtlh aeikaqkkel dtiqecikvk
      961 yapivsfeec erkfkateke lkdqlseqtq kysvseeevk knkqendklk keiftlqkdl
     1021 rdktvlieks hemeralsrk tdelnkqlkd lsqkytevkn vkeklveena kqtseilavq
     1081 nllqkqhvpl eqvealkksl ngtienlkee lksmqrcyek eqqtvtklhq llenqknssv
     1141 plaehlqike afekevgiik aslrekeees qnkmeevskl qsevqntkqa lkkletrevv
     1201 dlskykatks dletqissln eklanlnrky eevceevlha kkkeisakde kellhfsieq
     1261 eikdqkercd kslttitelq rriqesakqi eakdnkitel lndverlkqa lnglsqltyt
     1321 sgnptkrqsq lidtlqhqvk sleqqladad rqhqeviaiy rthllsaaqg hmdedvqeal
     1381 lqiiqmrqgl vc
//
LOCUS       XP_047288739            1164 aa            linear   PRI 05-AUG-2025
DEFINITION  uveal autoantigen with coiled-coil domains and ankyrin repeats
            isoform X6 [Homo sapiens].
ACCESSION   XP_047288739
VERSION     XP_047288739.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432783.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1164
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1164
                     /product="uveal autoantigen with coiled-coil domains and
                     ankyrin repeats isoform X6"
                     /calculated_mol_wt=135419
     Region          <50..469
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          293..1094
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1164
                     /gene="UACA"
                     /gene_synonym="NUCLING"
                     /coded_by="XM_047432783.1:73..3567"
                     /db_xref="GeneID:55075"
                     /db_xref="HGNC:HGNC:15947"
                     /db_xref="MIM:612516"
ORIGIN      
        1 mlipetnktg relwkkgpsl qqrnlthmqd evnvkshqre hqniqdleie nedlkerlrk
       61 iqqeqrilld kvnglqlqln eevmvaddle sereklksll aakekqhees lrtiealknr
      121 fkyfesdhlg sgshfsnrke dmllkqgqmy madsqctspg ipahmqsrsm lrplelslps
      181 qtsyseneil kkeleamrtf cesakqdrlk lqnelahkva eckalalece rvkedsdeqi
      241 kqledalkdv qkrmyesegk vkqmqthfla lkehltseaa sgnhrlteel kdqlkdlkvk
      301 yegasaevgk lrnqikqnem iveefkrdeg klieenkrlq kelsmcemer ekkgrkvtem
      361 egqakelsak lalsipaekf enmksslsne vnekakklve mereheksls eirqlkrele
      421 nvkaklaqhv kpeeheqvks rleqksgelg kkiteltlkn qtlqkeiekv yldnkllkeq
      481 ahnltiemkn hyvplkvsed mkkshdaiid dlnrklldvt qkytekklem eklllendsl
      541 skdvsrletv fvppekheke iialksnive lkkqlselkk kcgedqekih altsentnlk
      601 kmmsnqyvpv ktheevkmtl ndtlaktnre lldvkkkfed inqefvkikd kneilkrnle
      661 ntqnqikaey islaeheakm sslsqsmrkv qdsnaeilan yrkgqeeivt lhaeikaqkk
      721 eldtiqecik vkyapivsfe ecerkfkate kelkdqlseq tqkysvseee vkknkqendk
      781 lkkeiftlqk dlrdktvlie kshemerals rktdelnkql kdlsqkytev knvkeklvee
      841 nakqtseila vqnllqkqhv pleqvealkk slngtienlk eelksmqrcy ekeqqtvtkl
      901 hqllenqkns svplaehlqi keafekevgi ikaslrekee esqnkmeevs klqsevqntk
      961 qalkkletre vvdlskykat ksdletqiss lneklanlnr kyeevceevl hakkkeisak
     1021 dekellhfsi eqeikdqker cdkslttite lqrriqesak qieakdnkit ellndverlk
     1081 qalnglsqlt ytsgnptkrq sqlidtlqhq vksleqqlad adrqhqevia iyrthllsaa
     1141 qghmdedvqe allqiiqmrq glvc
//
LOCUS       XP_016877886             141 aa            linear   PRI 05-AUG-2025
DEFINITION  HAUS augmin-like complex subunit 2 isoform X1 [Homo sapiens].
ACCESSION   XP_016877886
VERSION     XP_016877886.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022397.2
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 25% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..141
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..141
                     /product="HAUS augmin-like complex subunit 2 isoform X1"
                     /calculated_mol_wt=16402
     Region          <1..96
                     /region_name="HAUS2"
                     /note="HAUS augmin-like complex subunit 2; pfam15003"
                     /db_xref="CDD:373465"
     CDS             1..141
                     /gene="HAUS2"
                     /gene_synonym="C15orf25; CEP27; HsT17025"
                     /coded_by="XM_017022397.2:314..739"
                     /db_xref="GeneID:55142"
                     /db_xref="HGNC:HGNC:25530"
                     /db_xref="MIM:613429"
ORIGIN      
        1 mnnhleavlk ekrslrqrll kpmcqenlpi eavyhrymvh llelavtfie rlethletir
       61 niphlaanlk kmnqalakmd ilvteteela enilkwrkqq nevsscipki laeesylykh
      121 diimpplpft skvhvqtina k
//
LOCUS       XP_011520057             264 aa            linear   PRI 05-AUG-2025
DEFINITION  regulator of microtubule dynamics protein 3 isoform X1 [Homo
            sapiens].
ACCESSION   XP_011520057
VERSION     XP_011520057.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521755.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..264
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..264
                     /product="regulator of microtubule dynamics protein 3
                     isoform X1"
                     /calculated_mol_wt=29578
     Region          36..>241
                     /region_name="Spy"
                     /note="Predicted O-linked N-acetylglucosamine transferase,
                     SPINDLY family [Posttranslational modification, protein
                     turnover, chaperones]; COG3914"
                     /db_xref="CDD:443119"
     Region          156..206
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          211..240
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..264
                     /gene="RMDN3"
                     /gene_synonym="FAM82A2; FAM82C; ptpip51; RMD-3; RMD3"
                     /coded_by="XM_011521755.3:199..993"
                     /db_xref="GeneID:55177"
                     /db_xref="HGNC:HGNC:25550"
                     /db_xref="MIM:611873"
ORIGIN      
        1 mgrkdsldle eeaasgassa leaggssgle dvlpllqqad elhrgdeqgk regfqlllnn
       61 klvygsrqdf lwrlaraysd mcelteevse kksyaldgke eaeaalekgd esadchlwya
      121 vlcgqlaehe siqrriqsgf sfkehvdkai alqpenpmah fllgrwcyqv shlswlekkt
      181 atallespls atvedalqsf lkaeelqpgf skagrvyisk cyrelgknse arwwmklale
      241 lpdvtkedla iqkdleelev ilrd
//
LOCUS       XP_005254998             757 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Lines homolog 1 isoform X1 [Homo sapiens].
ACCESSION   XP_005254998
VERSION     XP_005254998.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254941.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..757
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..757
                     /product="protein Lines homolog 1 isoform X1"
                     /calculated_mol_wt=85727
     Region          193..542
                     /region_name="LINES_N"
                     /note="Lines N-terminus; pfam14694"
                     /db_xref="CDD:464266"
     Region          712..747
                     /region_name="LINES_C"
                     /note="Lines C-terminus; pfam14695"
                     /db_xref="CDD:464267"
     CDS             1..757
                     /gene="LINS1"
                     /gene_synonym="LINS; MRT27; WINS1"
                     /coded_by="XM_005254941.3:172..2445"
                     /db_xref="GeneID:55180"
                     /db_xref="HGNC:HGNC:30922"
                     /db_xref="MIM:610350"
ORIGIN      
        1 mkvfcevlee lykkvllgat lendshdyif ylnpavsdqd cstatslewa ntcgiqgrhq
       61 pisvgvapia vapvclktns qmsgsrevml lqltvikvmt trilsvktef hakeqyrdvi
      121 killesakvd sklicmfqns dkllshmaaq clalllyfql rekitlsnsw iafcqknlse
      181 ysesnkaiyc lwtltaiike ifkdscsqkt eilkqflthf dtifevfyns lfsqhfencr
      241 dtskivnilm cfldllelli asrihlklhf tcqrilflkp scmlevitwp iqafvkrkvi
      301 iflkkcllck vgedlcrgsv palmppdhhv avdmlalana vlqavnsgll ktlsvyekhs
      361 ffggdevqpe celitspdhv ilraaslvim ksleikfqny ssasevkvdl qrfmselltf
      421 lkphlqpslq lhnpckwlsr vfieqdddml eaakaslgiy ltltrgceat esltqgkemw
      481 dhhthengyn phciflfflk nigfdstvll dflissetcf leyfvrylkl lqkdwdnfft
      541 icnnfdates kydisicgcv pslvqdqssn qtiphrltap hshrdvcarh swasdapsep
      601 lkavmskgah tmcasslssp rasqslvdyd ssddsdvest eqclanskqt slhqqatkei
      661 qdaagtsrdk kefsleppsr plvlkefdta fsfdcevapn dvvsevgify rivkcfqelq
      721 daicrlqkkn lfpynptall kllkyievis nktmntl
//
LOCUS       XP_024305748             757 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Lines homolog 1 isoform X1 [Homo sapiens].
ACCESSION   XP_024305748
VERSION     XP_024305748.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449980.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..757
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..757
                     /product="protein Lines homolog 1 isoform X1"
                     /calculated_mol_wt=85727
     Region          193..542
                     /region_name="LINES_N"
                     /note="Lines N-terminus; pfam14694"
                     /db_xref="CDD:464266"
     Region          712..747
                     /region_name="LINES_C"
                     /note="Lines C-terminus; pfam14695"
                     /db_xref="CDD:464267"
     CDS             1..757
                     /gene="LINS1"
                     /gene_synonym="LINS; MRT27; WINS1"
                     /coded_by="XM_024449980.2:1057..3330"
                     /db_xref="GeneID:55180"
                     /db_xref="HGNC:HGNC:30922"
                     /db_xref="MIM:610350"
ORIGIN      
        1 mkvfcevlee lykkvllgat lendshdyif ylnpavsdqd cstatslewa ntcgiqgrhq
       61 pisvgvapia vapvclktns qmsgsrevml lqltvikvmt trilsvktef hakeqyrdvi
      121 killesakvd sklicmfqns dkllshmaaq clalllyfql rekitlsnsw iafcqknlse
      181 ysesnkaiyc lwtltaiike ifkdscsqkt eilkqflthf dtifevfyns lfsqhfencr
      241 dtskivnilm cfldllelli asrihlklhf tcqrilflkp scmlevitwp iqafvkrkvi
      301 iflkkcllck vgedlcrgsv palmppdhhv avdmlalana vlqavnsgll ktlsvyekhs
      361 ffggdevqpe celitspdhv ilraaslvim ksleikfqny ssasevkvdl qrfmselltf
      421 lkphlqpslq lhnpckwlsr vfieqdddml eaakaslgiy ltltrgceat esltqgkemw
      481 dhhthengyn phciflfflk nigfdstvll dflissetcf leyfvrylkl lqkdwdnfft
      541 icnnfdates kydisicgcv pslvqdqssn qtiphrltap hshrdvcarh swasdapsep
      601 lkavmskgah tmcasslssp rasqslvdyd ssddsdvest eqclanskqt slhqqatkei
      661 qdaagtsrdk kefsleppsr plvlkefdta fsfdcevapn dvvsevgify rivkcfqelq
      721 daicrlqkkn lfpynptall kllkyievis nktmntl
//
LOCUS       XP_005255000             721 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Lines homolog 1 isoform X2 [Homo sapiens].
ACCESSION   XP_005255000
VERSION     XP_005255000.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254943.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..721
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..721
                     /product="protein Lines homolog 1 isoform X2"
                     /calculated_mol_wt=81408
     Region          193..506
                     /region_name="LINES_N"
                     /note="Lines N-terminus; pfam14694"
                     /db_xref="CDD:464266"
     Region          676..711
                     /region_name="LINES_C"
                     /note="Lines C-terminus; pfam14695"
                     /db_xref="CDD:464267"
     CDS             1..721
                     /gene="LINS1"
                     /gene_synonym="LINS; MRT27; WINS1"
                     /coded_by="XM_005254943.3:168..2333"
                     /db_xref="GeneID:55180"
                     /db_xref="HGNC:HGNC:30922"
                     /db_xref="MIM:610350"
ORIGIN      
        1 mkvfcevlee lykkvllgat lendshdyif ylnpavsdqd cstatslewa ntcgiqgrhq
       61 pisvgvapia vapvclktns qmsgsrevml lqltvikvmt trilsvktef hakeqyrdvi
      121 killesakvd sklicmfqns dkllshmaaq clalllyfql rekitlsnsw iafcqknlse
      181 ysesnkaiyc lwtltaiike ifkdscsqkt eilkqflthf dtifevfyns lfsqhfencr
      241 dtskivnilm cfldllelli asrihlklhf tcqrilflkp scmlevitwp iqafvkrkvi
      301 iflkkcllck vgedlcrgsv palmppdhhv avdmlalana vlqavnsgll ktlsvyekhs
      361 ffggdevqpe celitspdhv ilraaslvim ksleikfqny ssasevkeqd ddmleaakas
      421 lgiyltltrg ceatesltqg kemwdhhthe ngynphcifl fflknigfds tvlldfliss
      481 etcfleyfvr ylkllqkdwd nffticnnfd ateskydisi cgcvpslvqd qssnqtiphr
      541 ltaphshrdv carhswasda pseplkavms kgahtmcass lssprasqsl vdydssddsd
      601 vesteqclan skqtslhqqa tkeiqdaagt srdkkefsle ppsrplvlke fdtafsfdce
      661 vapndvvsev gifyrivkcf qelqdaicrl qkknlfpynp tallkllkyi evisnktmnt
      721 l
//
LOCUS       XP_047288740             721 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Lines homolog 1 isoform X2 [Homo sapiens].
ACCESSION   XP_047288740
VERSION     XP_047288740.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432784.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..721
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..721
                     /product="protein Lines homolog 1 isoform X2"
                     /calculated_mol_wt=81408
     Region          193..506
                     /region_name="LINES_N"
                     /note="Lines N-terminus; pfam14694"
                     /db_xref="CDD:464266"
     Region          676..711
                     /region_name="LINES_C"
                     /note="Lines C-terminus; pfam14695"
                     /db_xref="CDD:464267"
     CDS             1..721
                     /gene="LINS1"
                     /gene_synonym="LINS; MRT27; WINS1"
                     /coded_by="XM_047432784.1:172..2337"
                     /db_xref="GeneID:55180"
                     /db_xref="HGNC:HGNC:30922"
                     /db_xref="MIM:610350"
ORIGIN      
        1 mkvfcevlee lykkvllgat lendshdyif ylnpavsdqd cstatslewa ntcgiqgrhq
       61 pisvgvapia vapvclktns qmsgsrevml lqltvikvmt trilsvktef hakeqyrdvi
      121 killesakvd sklicmfqns dkllshmaaq clalllyfql rekitlsnsw iafcqknlse
      181 ysesnkaiyc lwtltaiike ifkdscsqkt eilkqflthf dtifevfyns lfsqhfencr
      241 dtskivnilm cfldllelli asrihlklhf tcqrilflkp scmlevitwp iqafvkrkvi
      301 iflkkcllck vgedlcrgsv palmppdhhv avdmlalana vlqavnsgll ktlsvyekhs
      361 ffggdevqpe celitspdhv ilraaslvim ksleikfqny ssasevkeqd ddmleaakas
      421 lgiyltltrg ceatesltqg kemwdhhthe ngynphcifl fflknigfds tvlldfliss
      481 etcfleyfvr ylkllqkdwd nffticnnfd ateskydisi cgcvpslvqd qssnqtiphr
      541 ltaphshrdv carhswasda pseplkavms kgahtmcass lssprasqsl vdydssddsd
      601 vesteqclan skqtslhqqa tkeiqdaagt srdkkefsle ppsrplvlke fdtafsfdce
      661 vapndvvsev gifyrivkcf qelqdaicrl qkknlfpynp tallkllkyi evisnktmnt
      721 l
//
LOCUS       XP_047288741             721 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Lines homolog 1 isoform X2 [Homo sapiens].
ACCESSION   XP_047288741
VERSION     XP_047288741.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432785.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..721
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..721
                     /product="protein Lines homolog 1 isoform X2"
                     /calculated_mol_wt=81408
     Region          193..506
                     /region_name="LINES_N"
                     /note="Lines N-terminus; pfam14694"
                     /db_xref="CDD:464266"
     Region          676..711
                     /region_name="LINES_C"
                     /note="Lines C-terminus; pfam14695"
                     /db_xref="CDD:464267"
     CDS             1..721
                     /gene="LINS1"
                     /gene_synonym="LINS; MRT27; WINS1"
                     /coded_by="XM_047432785.1:1057..3222"
                     /db_xref="GeneID:55180"
                     /db_xref="HGNC:HGNC:30922"
                     /db_xref="MIM:610350"
ORIGIN      
        1 mkvfcevlee lykkvllgat lendshdyif ylnpavsdqd cstatslewa ntcgiqgrhq
       61 pisvgvapia vapvclktns qmsgsrevml lqltvikvmt trilsvktef hakeqyrdvi
      121 killesakvd sklicmfqns dkllshmaaq clalllyfql rekitlsnsw iafcqknlse
      181 ysesnkaiyc lwtltaiike ifkdscsqkt eilkqflthf dtifevfyns lfsqhfencr
      241 dtskivnilm cfldllelli asrihlklhf tcqrilflkp scmlevitwp iqafvkrkvi
      301 iflkkcllck vgedlcrgsv palmppdhhv avdmlalana vlqavnsgll ktlsvyekhs
      361 ffggdevqpe celitspdhv ilraaslvim ksleikfqny ssasevkeqd ddmleaakas
      421 lgiyltltrg ceatesltqg kemwdhhthe ngynphcifl fflknigfds tvlldfliss
      481 etcfleyfvr ylkllqkdwd nffticnnfd ateskydisi cgcvpslvqd qssnqtiphr
      541 ltaphshrdv carhswasda pseplkavms kgahtmcass lssprasqsl vdydssddsd
      601 vesteqclan skqtslhqqa tkeiqdaagt srdkkefsle ppsrplvlke fdtafsfdce
      661 vapndvvsev gifyrivkcf qelqdaicrl qkknlfpynp tallkllkyi evisnktmnt
      721 l
//
LOCUS       XP_047288742             409 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Lines homolog 1 isoform X3 [Homo sapiens].
ACCESSION   XP_047288742
VERSION     XP_047288742.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432786.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..409
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..409
                     /product="protein Lines homolog 1 isoform X3"
                     /calculated_mol_wt=46139
     Region          193..>409
                     /region_name="LINES_N"
                     /note="Lines N-terminus; pfam14694"
                     /db_xref="CDD:464266"
     CDS             1..409
                     /gene="LINS1"
                     /gene_synonym="LINS; MRT27; WINS1"
                     /coded_by="XM_047432786.1:168..1397"
                     /db_xref="GeneID:55180"
                     /db_xref="HGNC:HGNC:30922"
                     /db_xref="MIM:610350"
ORIGIN      
        1 mkvfcevlee lykkvllgat lendshdyif ylnpavsdqd cstatslewa ntcgiqgrhq
       61 pisvgvapia vapvclktns qmsgsrevml lqltvikvmt trilsvktef hakeqyrdvi
      121 killesakvd sklicmfqns dkllshmaaq clalllyfql rekitlsnsw iafcqknlse
      181 ysesnkaiyc lwtltaiike ifkdscsqkt eilkqflthf dtifevfyns lfsqhfencr
      241 dtskivnilm cfldllelli asrihlklhf tcqrilflkp scmlevitwp iqafvkrkvi
      301 iflkkcllck vgedlcrgsv palmppdhhv avdmlalana vlqavnsgll ktlsvyekhs
      361 ffggdevqpe celitspdhv ilraaslvim ksleikfqny ssasevkga
//
LOCUS       XP_047288743             409 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Lines homolog 1 isoform X3 [Homo sapiens].
ACCESSION   XP_047288743
VERSION     XP_047288743.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432787.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..409
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..409
                     /product="protein Lines homolog 1 isoform X3"
                     /calculated_mol_wt=46139
     Region          193..>409
                     /region_name="LINES_N"
                     /note="Lines N-terminus; pfam14694"
                     /db_xref="CDD:464266"
     CDS             1..409
                     /gene="LINS1"
                     /gene_synonym="LINS; MRT27; WINS1"
                     /coded_by="XM_047432787.1:1057..2286"
                     /db_xref="GeneID:55180"
                     /db_xref="HGNC:HGNC:30922"
                     /db_xref="MIM:610350"
ORIGIN      
        1 mkvfcevlee lykkvllgat lendshdyif ylnpavsdqd cstatslewa ntcgiqgrhq
       61 pisvgvapia vapvclktns qmsgsrevml lqltvikvmt trilsvktef hakeqyrdvi
      121 killesakvd sklicmfqns dkllshmaaq clalllyfql rekitlsnsw iafcqknlse
      181 ysesnkaiyc lwtltaiike ifkdscsqkt eilkqflthf dtifevfyns lfsqhfencr
      241 dtskivnilm cfldllelli asrihlklhf tcqrilflkp scmlevitwp iqafvkrkvi
      301 iflkkcllck vgedlcrgsv palmppdhhv avdmlalana vlqavnsgll ktlsvyekhs
      361 ffggdevqpe celitspdhv ilraaslvim ksleikfqny ssasevkga
//
LOCUS       XP_016877888             508 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Lines homolog 1 isoform X4 [Homo sapiens].
ACCESSION   XP_016877888
VERSION     XP_016877888.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022399.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..508
                     /product="protein Lines homolog 1 isoform X4"
                     /calculated_mol_wt=57306
     Region          1..293
                     /region_name="LINES_N"
                     /note="Lines N-terminus; pfam14694"
                     /db_xref="CDD:464266"
     Region          463..498
                     /region_name="LINES_C"
                     /note="Lines C-terminus; pfam14695"
                     /db_xref="CDD:464267"
     CDS             1..508
                     /gene="LINS1"
                     /gene_synonym="LINS; MRT27; WINS1"
                     /coded_by="XM_017022399.3:281..1807"
                     /db_xref="GeneID:55180"
                     /db_xref="HGNC:HGNC:30922"
                     /db_xref="MIM:610350"
ORIGIN      
        1 mcfldllell iasrihlklh ftcqrilflk pscmlevitw piqafvkrkv iiflkkcllc
       61 kvgedlcrgs vpalmppdhh vavdmlalan avlqavnsgl lktlsvyekh sffggdevqp
      121 ecelitspdh vilraaslvi mksleikfqn yssasevkvd lqrfmsellt flkphlqpsl
      181 qlhnpckwls rvfieqdddm leaakaslgi yltltrgcea tesltqgkem wdhhthengy
      241 nphciflffl knigfdstvl ldflissetc fleyfvrylk llqkdwdnff ticnnfdate
      301 skydisicgc vpslvqdqss nqtiphrlta phshrdvcar hswasdapse plkavmskga
      361 htmcasslss prasqslvdy dssddsdves teqclanskq tslhqqatke iqdaagtsrd
      421 kkefslepps rplvlkefdt afsfdcevap ndvvsevgif yrivkcfqel qdaicrlqkk
      481 nlfpynptal lkllkyievi snktmntl
//
LOCUS       XP_047288744             220 aa            linear   PRI 05-AUG-2025
DEFINITION  dnaJ homolog subfamily C member 17 isoform X1 [Homo sapiens].
ACCESSION   XP_047288744
VERSION     XP_047288744.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432788.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..220
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..220
                     /product="dnaJ homolog subfamily C member 17 isoform X1"
                     /calculated_mol_wt=25222
     Region          11..73
                     /region_name="DnaJ"
                     /note="DnaJ domain; pfam00226"
                     /db_xref="CDD:395170"
     Site            order(39..41,50,53..54,57..58)
                     /site_type="other"
                     /note="HSP70 interaction site [polypeptide binding]"
                     /db_xref="CDD:99751"
     CDS             1..220
                     /gene="DNAJC17"
                     /coded_by="XM_047432788.1:28..690"
                     /db_xref="GeneID:55192"
                     /db_xref="HGNC:HGNC:25556"
                     /db_xref="MIM:616844"
ORIGIN      
        1 mavtkellqm dlyallgiee kaadkevkka yrqkalschp dknpdnpraa elfhqlsqal
       61 evltdaaara aydkvrkakk qaaertqkld ekrkkvkldl earerqaqaq eseeeeesrs
      121 trtleqeier lreegsrqle eqqrlireqi rqerdqrlrg kaentegqgt pklklkwkck
      181 kedeskggys kdvllrllqk vgpvdvhsfl ssqstsqstp
//
LOCUS       XP_011520058            1328 aa            linear   PRI 05-AUG-2025
DEFINITION  Fanconi anemia group I protein isoform X1 [Homo sapiens].
ACCESSION   XP_011520058
VERSION     XP_011520058.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521756.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1328
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1328
                     /product="Fanconi anemia group I protein isoform X1"
                     /calculated_mol_wt=149193
     Region          1..53
                     /region_name="FANCI_S1-cap"
                     /note="FANCI solenoid 1 cap; pfam14674"
                     /db_xref="CDD:434117"
     Region          43..1290
                     /region_name="FANCI"
                     /note="Fanconi anemia I protein; cd11720"
                     /db_xref="CDD:212594"
     Site            order(48,52,83..84,87,90..91,94..95,98,128,131,182..183,
                     215,219,273,277,280,376,442,446,449,480,483,486..487,490,
                     522..523,526,581..582,585..586,589..590,592..593,616,
                     618..622,625,628,678,689)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:212594"
     Site            order(287,291,294,331,336,339,980,1026,1078,1094,1107,
                     1164,1168,1178,1262,1269..1270)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212594"
     CDS             1..1328
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /coded_by="XM_011521756.3:109..4095"
                     /db_xref="GeneID:55215"
                     /db_xref="HGNC:HGNC:25568"
                     /db_xref="MIM:611360"
ORIGIN      
        1 mdqkilslaa ektadklqef lqtlregdlt nllqnqavkg kvagallrai fkgspcseea
       61 gtlrrrkiyt cciqlvesgd lqkeiaseii gllmleahhf pgpllvelan efisavregs
      121 lvngkslell piiltalatk kenlaygkgv lsgeeckkql intlcsgrwd qqyviqltsm
      181 fkdvpltaee vefvvekals mfskmnlqei pplvyqllvl sskgsrksvl egiiaffsal
      241 dkqhneeqsg delldvvtvp sgelrhvegt iilhivfaik ldyelgrelv khlkvgqqgd
      301 snnnlspfsi alllsvtriq rfqdqvldll ktsvvksfkd lqllqgskfl qnlvphrsyv
      361 stmilevvkn svhswdhvtq glvelgfilm dsygpkkvld gktietspsl srmpnqhack
      421 lganilletf kihemirqei leqvlnrvvt rasspishfl dllsnivmya plvlqscssk
      481 vteafdylsf lplqtvqrll kavqpllkvs msmrdclilv lrkamfanql darksavagf
      541 llllknfkvl gslsssqcsq slsvsqvhvd vhshynsvan etfcleimds lrrclsqqad
      601 vrlmlyegfy dvlrrnsqla nsvmqtllsq lkqfyepkpd llpplkleac iltqgdkisl
      661 qepldyllcc iqhclawykn tviplqqgee eeeeeeafye dlddilesit nrmikseled
      721 feldksadfs qstsigiknn icaflvmgvc evlieynfsi ssfsknrfed ilslfmcykk
      781 lsdilnekag kaktkmankt sdsllsmkfv sslltalfrd siqshqesls vlrssnefmr
      841 yavnvalqkv qqlketghvs gpdgqnpeki fqnlcditrv llwrytsipt sveesgkkek
      901 gksisllcle glqkifsavq qfyqpkiqqf lraldvtdke geeredadvs vtqrtafqir
      961 qfqrsllnll ssqeedfnsk ealllvtvlt slskllepss pqfvqmlswt skickensre
     1021 dalfckslmn llfslhvsyk spvillrdls qdihghlgdi dqdvevektn hfaivnlrta
     1081 aptvcllvls qaekvleevd wlitklkgqv sqetlseeas sqatlpnqpv ekaiimqlgt
     1141 lltffhelvq talpsgscvd tllkdlckmy ttltalvryy lqvcqssggi pknmeklvkl
     1201 sgshltplcy sfisyvqnks kslnytgekk ekpaavatam arvlretkpi pnlifaieqy
     1261 ekflihlskk skvnlmqhmk lstsrdfkik gnildmvlre dgedeneegt asehggqnke
     1321 pakkkrkk
//
LOCUS       XP_047288745            1328 aa            linear   PRI 05-AUG-2025
DEFINITION  Fanconi anemia group I protein isoform X1 [Homo sapiens].
ACCESSION   XP_047288745
VERSION     XP_047288745.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432789.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1328
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1328
                     /product="Fanconi anemia group I protein isoform X1"
                     /calculated_mol_wt=149193
     Region          1..53
                     /region_name="FANCI_S1-cap"
                     /note="FANCI solenoid 1 cap; pfam14674"
                     /db_xref="CDD:434117"
     Region          43..1290
                     /region_name="FANCI"
                     /note="Fanconi anemia I protein; cd11720"
                     /db_xref="CDD:212594"
     Site            order(48,52,83..84,87,90..91,94..95,98,128,131,182..183,
                     215,219,273,277,280,376,442,446,449,480,483,486..487,490,
                     522..523,526,581..582,585..586,589..590,592..593,616,
                     618..622,625,628,678,689)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:212594"
     Site            order(287,291,294,331,336,339,980,1026,1078,1094,1107,
                     1164,1168,1178,1262,1269..1270)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212594"
     CDS             1..1328
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /coded_by="XM_047432789.1:1353..5339"
                     /db_xref="GeneID:55215"
                     /db_xref="HGNC:HGNC:25568"
                     /db_xref="MIM:611360"
ORIGIN      
        1 mdqkilslaa ektadklqef lqtlregdlt nllqnqavkg kvagallrai fkgspcseea
       61 gtlrrrkiyt cciqlvesgd lqkeiaseii gllmleahhf pgpllvelan efisavregs
      121 lvngkslell piiltalatk kenlaygkgv lsgeeckkql intlcsgrwd qqyviqltsm
      181 fkdvpltaee vefvvekals mfskmnlqei pplvyqllvl sskgsrksvl egiiaffsal
      241 dkqhneeqsg delldvvtvp sgelrhvegt iilhivfaik ldyelgrelv khlkvgqqgd
      301 snnnlspfsi alllsvtriq rfqdqvldll ktsvvksfkd lqllqgskfl qnlvphrsyv
      361 stmilevvkn svhswdhvtq glvelgfilm dsygpkkvld gktietspsl srmpnqhack
      421 lganilletf kihemirqei leqvlnrvvt rasspishfl dllsnivmya plvlqscssk
      481 vteafdylsf lplqtvqrll kavqpllkvs msmrdclilv lrkamfanql darksavagf
      541 llllknfkvl gslsssqcsq slsvsqvhvd vhshynsvan etfcleimds lrrclsqqad
      601 vrlmlyegfy dvlrrnsqla nsvmqtllsq lkqfyepkpd llpplkleac iltqgdkisl
      661 qepldyllcc iqhclawykn tviplqqgee eeeeeeafye dlddilesit nrmikseled
      721 feldksadfs qstsigiknn icaflvmgvc evlieynfsi ssfsknrfed ilslfmcykk
      781 lsdilnekag kaktkmankt sdsllsmkfv sslltalfrd siqshqesls vlrssnefmr
      841 yavnvalqkv qqlketghvs gpdgqnpeki fqnlcditrv llwrytsipt sveesgkkek
      901 gksisllcle glqkifsavq qfyqpkiqqf lraldvtdke geeredadvs vtqrtafqir
      961 qfqrsllnll ssqeedfnsk ealllvtvlt slskllepss pqfvqmlswt skickensre
     1021 dalfckslmn llfslhvsyk spvillrdls qdihghlgdi dqdvevektn hfaivnlrta
     1081 aptvcllvls qaekvleevd wlitklkgqv sqetlseeas sqatlpnqpv ekaiimqlgt
     1141 lltffhelvq talpsgscvd tllkdlckmy ttltalvryy lqvcqssggi pknmeklvkl
     1201 sgshltplcy sfisyvqnks kslnytgekk ekpaavatam arvlretkpi pnlifaieqy
     1261 ekflihlskk skvnlmqhmk lstsrdfkik gnildmvlre dgedeneegt asehggqnke
     1321 pakkkrkk
//
LOCUS       XP_047288746            1328 aa            linear   PRI 05-AUG-2025
DEFINITION  Fanconi anemia group I protein isoform X1 [Homo sapiens].
ACCESSION   XP_047288746
VERSION     XP_047288746.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432790.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1328
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1328
                     /product="Fanconi anemia group I protein isoform X1"
                     /calculated_mol_wt=149193
     Region          1..53
                     /region_name="FANCI_S1-cap"
                     /note="FANCI solenoid 1 cap; pfam14674"
                     /db_xref="CDD:434117"
     Region          43..1290
                     /region_name="FANCI"
                     /note="Fanconi anemia I protein; cd11720"
                     /db_xref="CDD:212594"
     Site            order(48,52,83..84,87,90..91,94..95,98,128,131,182..183,
                     215,219,273,277,280,376,442,446,449,480,483,486..487,490,
                     522..523,526,581..582,585..586,589..590,592..593,616,
                     618..622,625,628,678,689)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:212594"
     Site            order(287,291,294,331,336,339,980,1026,1078,1094,1107,
                     1164,1168,1178,1262,1269..1270)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212594"
     CDS             1..1328
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /coded_by="XM_047432790.1:193..4179"
                     /db_xref="GeneID:55215"
                     /db_xref="HGNC:HGNC:25568"
                     /db_xref="MIM:611360"
ORIGIN      
        1 mdqkilslaa ektadklqef lqtlregdlt nllqnqavkg kvagallrai fkgspcseea
       61 gtlrrrkiyt cciqlvesgd lqkeiaseii gllmleahhf pgpllvelan efisavregs
      121 lvngkslell piiltalatk kenlaygkgv lsgeeckkql intlcsgrwd qqyviqltsm
      181 fkdvpltaee vefvvekals mfskmnlqei pplvyqllvl sskgsrksvl egiiaffsal
      241 dkqhneeqsg delldvvtvp sgelrhvegt iilhivfaik ldyelgrelv khlkvgqqgd
      301 snnnlspfsi alllsvtriq rfqdqvldll ktsvvksfkd lqllqgskfl qnlvphrsyv
      361 stmilevvkn svhswdhvtq glvelgfilm dsygpkkvld gktietspsl srmpnqhack
      421 lganilletf kihemirqei leqvlnrvvt rasspishfl dllsnivmya plvlqscssk
      481 vteafdylsf lplqtvqrll kavqpllkvs msmrdclilv lrkamfanql darksavagf
      541 llllknfkvl gslsssqcsq slsvsqvhvd vhshynsvan etfcleimds lrrclsqqad
      601 vrlmlyegfy dvlrrnsqla nsvmqtllsq lkqfyepkpd llpplkleac iltqgdkisl
      661 qepldyllcc iqhclawykn tviplqqgee eeeeeeafye dlddilesit nrmikseled
      721 feldksadfs qstsigiknn icaflvmgvc evlieynfsi ssfsknrfed ilslfmcykk
      781 lsdilnekag kaktkmankt sdsllsmkfv sslltalfrd siqshqesls vlrssnefmr
      841 yavnvalqkv qqlketghvs gpdgqnpeki fqnlcditrv llwrytsipt sveesgkkek
      901 gksisllcle glqkifsavq qfyqpkiqqf lraldvtdke geeredadvs vtqrtafqir
      961 qfqrsllnll ssqeedfnsk ealllvtvlt slskllepss pqfvqmlswt skickensre
     1021 dalfckslmn llfslhvsyk spvillrdls qdihghlgdi dqdvevektn hfaivnlrta
     1081 aptvcllvls qaekvleevd wlitklkgqv sqetlseeas sqatlpnqpv ekaiimqlgt
     1141 lltffhelvq talpsgscvd tllkdlckmy ttltalvryy lqvcqssggi pknmeklvkl
     1201 sgshltplcy sfisyvqnks kslnytgekk ekpaavatam arvlretkpi pnlifaieqy
     1261 ekflihlskk skvnlmqhmk lstsrdfkik gnildmvlre dgedeneegt asehggqnke
     1321 pakkkrkk
//
LOCUS       XP_047288747            1328 aa            linear   PRI 05-AUG-2025
DEFINITION  Fanconi anemia group I protein isoform X1 [Homo sapiens].
ACCESSION   XP_047288747
VERSION     XP_047288747.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432791.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1328
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1328
                     /product="Fanconi anemia group I protein isoform X1"
                     /calculated_mol_wt=149193
     Region          1..53
                     /region_name="FANCI_S1-cap"
                     /note="FANCI solenoid 1 cap; pfam14674"
                     /db_xref="CDD:434117"
     Region          43..1290
                     /region_name="FANCI"
                     /note="Fanconi anemia I protein; cd11720"
                     /db_xref="CDD:212594"
     Site            order(48,52,83..84,87,90..91,94..95,98,128,131,182..183,
                     215,219,273,277,280,376,442,446,449,480,483,486..487,490,
                     522..523,526,581..582,585..586,589..590,592..593,616,
                     618..622,625,628,678,689)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:212594"
     Site            order(287,291,294,331,336,339,980,1026,1078,1094,1107,
                     1164,1168,1178,1262,1269..1270)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212594"
     CDS             1..1328
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /coded_by="XM_047432791.1:159..4145"
                     /db_xref="GeneID:55215"
                     /db_xref="HGNC:HGNC:25568"
                     /db_xref="MIM:611360"
ORIGIN      
        1 mdqkilslaa ektadklqef lqtlregdlt nllqnqavkg kvagallrai fkgspcseea
       61 gtlrrrkiyt cciqlvesgd lqkeiaseii gllmleahhf pgpllvelan efisavregs
      121 lvngkslell piiltalatk kenlaygkgv lsgeeckkql intlcsgrwd qqyviqltsm
      181 fkdvpltaee vefvvekals mfskmnlqei pplvyqllvl sskgsrksvl egiiaffsal
      241 dkqhneeqsg delldvvtvp sgelrhvegt iilhivfaik ldyelgrelv khlkvgqqgd
      301 snnnlspfsi alllsvtriq rfqdqvldll ktsvvksfkd lqllqgskfl qnlvphrsyv
      361 stmilevvkn svhswdhvtq glvelgfilm dsygpkkvld gktietspsl srmpnqhack
      421 lganilletf kihemirqei leqvlnrvvt rasspishfl dllsnivmya plvlqscssk
      481 vteafdylsf lplqtvqrll kavqpllkvs msmrdclilv lrkamfanql darksavagf
      541 llllknfkvl gslsssqcsq slsvsqvhvd vhshynsvan etfcleimds lrrclsqqad
      601 vrlmlyegfy dvlrrnsqla nsvmqtllsq lkqfyepkpd llpplkleac iltqgdkisl
      661 qepldyllcc iqhclawykn tviplqqgee eeeeeeafye dlddilesit nrmikseled
      721 feldksadfs qstsigiknn icaflvmgvc evlieynfsi ssfsknrfed ilslfmcykk
      781 lsdilnekag kaktkmankt sdsllsmkfv sslltalfrd siqshqesls vlrssnefmr
      841 yavnvalqkv qqlketghvs gpdgqnpeki fqnlcditrv llwrytsipt sveesgkkek
      901 gksisllcle glqkifsavq qfyqpkiqqf lraldvtdke geeredadvs vtqrtafqir
      961 qfqrsllnll ssqeedfnsk ealllvtvlt slskllepss pqfvqmlswt skickensre
     1021 dalfckslmn llfslhvsyk spvillrdls qdihghlgdi dqdvevektn hfaivnlrta
     1081 aptvcllvls qaekvleevd wlitklkgqv sqetlseeas sqatlpnqpv ekaiimqlgt
     1141 lltffhelvq talpsgscvd tllkdlckmy ttltalvryy lqvcqssggi pknmeklvkl
     1201 sgshltplcy sfisyvqnks kslnytgekk ekpaavatam arvlretkpi pnlifaieqy
     1261 ekflihlskk skvnlmqhmk lstsrdfkik gnildmvlre dgedeneegt asehggqnke
     1321 pakkkrkk
//
LOCUS       XP_047288748            1328 aa            linear   PRI 05-AUG-2025
DEFINITION  Fanconi anemia group I protein isoform X1 [Homo sapiens].
ACCESSION   XP_047288748
VERSION     XP_047288748.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432792.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1328
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1328
                     /product="Fanconi anemia group I protein isoform X1"
                     /calculated_mol_wt=149193
     Region          1..53
                     /region_name="FANCI_S1-cap"
                     /note="FANCI solenoid 1 cap; pfam14674"
                     /db_xref="CDD:434117"
     Region          43..1290
                     /region_name="FANCI"
                     /note="Fanconi anemia I protein; cd11720"
                     /db_xref="CDD:212594"
     Site            order(48,52,83..84,87,90..91,94..95,98,128,131,182..183,
                     215,219,273,277,280,376,442,446,449,480,483,486..487,490,
                     522..523,526,581..582,585..586,589..590,592..593,616,
                     618..622,625,628,678,689)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:212594"
     Site            order(287,291,294,331,336,339,980,1026,1078,1094,1107,
                     1164,1168,1178,1262,1269..1270)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212594"
     CDS             1..1328
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /coded_by="XM_047432792.1:177..4163"
                     /db_xref="GeneID:55215"
                     /db_xref="HGNC:HGNC:25568"
                     /db_xref="MIM:611360"
ORIGIN      
        1 mdqkilslaa ektadklqef lqtlregdlt nllqnqavkg kvagallrai fkgspcseea
       61 gtlrrrkiyt cciqlvesgd lqkeiaseii gllmleahhf pgpllvelan efisavregs
      121 lvngkslell piiltalatk kenlaygkgv lsgeeckkql intlcsgrwd qqyviqltsm
      181 fkdvpltaee vefvvekals mfskmnlqei pplvyqllvl sskgsrksvl egiiaffsal
      241 dkqhneeqsg delldvvtvp sgelrhvegt iilhivfaik ldyelgrelv khlkvgqqgd
      301 snnnlspfsi alllsvtriq rfqdqvldll ktsvvksfkd lqllqgskfl qnlvphrsyv
      361 stmilevvkn svhswdhvtq glvelgfilm dsygpkkvld gktietspsl srmpnqhack
      421 lganilletf kihemirqei leqvlnrvvt rasspishfl dllsnivmya plvlqscssk
      481 vteafdylsf lplqtvqrll kavqpllkvs msmrdclilv lrkamfanql darksavagf
      541 llllknfkvl gslsssqcsq slsvsqvhvd vhshynsvan etfcleimds lrrclsqqad
      601 vrlmlyegfy dvlrrnsqla nsvmqtllsq lkqfyepkpd llpplkleac iltqgdkisl
      661 qepldyllcc iqhclawykn tviplqqgee eeeeeeafye dlddilesit nrmikseled
      721 feldksadfs qstsigiknn icaflvmgvc evlieynfsi ssfsknrfed ilslfmcykk
      781 lsdilnekag kaktkmankt sdsllsmkfv sslltalfrd siqshqesls vlrssnefmr
      841 yavnvalqkv qqlketghvs gpdgqnpeki fqnlcditrv llwrytsipt sveesgkkek
      901 gksisllcle glqkifsavq qfyqpkiqqf lraldvtdke geeredadvs vtqrtafqir
      961 qfqrsllnll ssqeedfnsk ealllvtvlt slskllepss pqfvqmlswt skickensre
     1021 dalfckslmn llfslhvsyk spvillrdls qdihghlgdi dqdvevektn hfaivnlrta
     1081 aptvcllvls qaekvleevd wlitklkgqv sqetlseeas sqatlpnqpv ekaiimqlgt
     1141 lltffhelvq talpsgscvd tllkdlckmy ttltalvryy lqvcqssggi pknmeklvkl
     1201 sgshltplcy sfisyvqnks kslnytgekk ekpaavatam arvlretkpi pnlifaieqy
     1261 ekflihlskk skvnlmqhmk lstsrdfkik gnildmvlre dgedeneegt asehggqnke
     1321 pakkkrkk
//
LOCUS       XP_047288749            1328 aa            linear   PRI 05-AUG-2025
DEFINITION  Fanconi anemia group I protein isoform X1 [Homo sapiens].
ACCESSION   XP_047288749
VERSION     XP_047288749.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432793.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1328
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1328
                     /product="Fanconi anemia group I protein isoform X1"
                     /calculated_mol_wt=149193
     Region          1..53
                     /region_name="FANCI_S1-cap"
                     /note="FANCI solenoid 1 cap; pfam14674"
                     /db_xref="CDD:434117"
     Region          43..1290
                     /region_name="FANCI"
                     /note="Fanconi anemia I protein; cd11720"
                     /db_xref="CDD:212594"
     Site            order(48,52,83..84,87,90..91,94..95,98,128,131,182..183,
                     215,219,273,277,280,376,442,446,449,480,483,486..487,490,
                     522..523,526,581..582,585..586,589..590,592..593,616,
                     618..622,625,628,678,689)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:212594"
     Site            order(287,291,294,331,336,339,980,1026,1078,1094,1107,
                     1164,1168,1178,1262,1269..1270)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212594"
     CDS             1..1328
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /coded_by="XM_047432793.1:1891..5877"
                     /db_xref="GeneID:55215"
                     /db_xref="HGNC:HGNC:25568"
                     /db_xref="MIM:611360"
ORIGIN      
        1 mdqkilslaa ektadklqef lqtlregdlt nllqnqavkg kvagallrai fkgspcseea
       61 gtlrrrkiyt cciqlvesgd lqkeiaseii gllmleahhf pgpllvelan efisavregs
      121 lvngkslell piiltalatk kenlaygkgv lsgeeckkql intlcsgrwd qqyviqltsm
      181 fkdvpltaee vefvvekals mfskmnlqei pplvyqllvl sskgsrksvl egiiaffsal
      241 dkqhneeqsg delldvvtvp sgelrhvegt iilhivfaik ldyelgrelv khlkvgqqgd
      301 snnnlspfsi alllsvtriq rfqdqvldll ktsvvksfkd lqllqgskfl qnlvphrsyv
      361 stmilevvkn svhswdhvtq glvelgfilm dsygpkkvld gktietspsl srmpnqhack
      421 lganilletf kihemirqei leqvlnrvvt rasspishfl dllsnivmya plvlqscssk
      481 vteafdylsf lplqtvqrll kavqpllkvs msmrdclilv lrkamfanql darksavagf
      541 llllknfkvl gslsssqcsq slsvsqvhvd vhshynsvan etfcleimds lrrclsqqad
      601 vrlmlyegfy dvlrrnsqla nsvmqtllsq lkqfyepkpd llpplkleac iltqgdkisl
      661 qepldyllcc iqhclawykn tviplqqgee eeeeeeafye dlddilesit nrmikseled
      721 feldksadfs qstsigiknn icaflvmgvc evlieynfsi ssfsknrfed ilslfmcykk
      781 lsdilnekag kaktkmankt sdsllsmkfv sslltalfrd siqshqesls vlrssnefmr
      841 yavnvalqkv qqlketghvs gpdgqnpeki fqnlcditrv llwrytsipt sveesgkkek
      901 gksisllcle glqkifsavq qfyqpkiqqf lraldvtdke geeredadvs vtqrtafqir
      961 qfqrsllnll ssqeedfnsk ealllvtvlt slskllepss pqfvqmlswt skickensre
     1021 dalfckslmn llfslhvsyk spvillrdls qdihghlgdi dqdvevektn hfaivnlrta
     1081 aptvcllvls qaekvleevd wlitklkgqv sqetlseeas sqatlpnqpv ekaiimqlgt
     1141 lltffhelvq talpsgscvd tllkdlckmy ttltalvryy lqvcqssggi pknmeklvkl
     1201 sgshltplcy sfisyvqnks kslnytgekk ekpaavatam arvlretkpi pnlifaieqy
     1261 ekflihlskk skvnlmqhmk lstsrdfkik gnildmvlre dgedeneegt asehggqnke
     1321 pakkkrkk
//
LOCUS       XP_047288750            1328 aa            linear   PRI 05-AUG-2025
DEFINITION  Fanconi anemia group I protein isoform X1 [Homo sapiens].
ACCESSION   XP_047288750
VERSION     XP_047288750.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432794.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1328
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1328
                     /product="Fanconi anemia group I protein isoform X1"
                     /calculated_mol_wt=149193
     Region          1..53
                     /region_name="FANCI_S1-cap"
                     /note="FANCI solenoid 1 cap; pfam14674"
                     /db_xref="CDD:434117"
     Region          43..1290
                     /region_name="FANCI"
                     /note="Fanconi anemia I protein; cd11720"
                     /db_xref="CDD:212594"
     Site            order(48,52,83..84,87,90..91,94..95,98,128,131,182..183,
                     215,219,273,277,280,376,442,446,449,480,483,486..487,490,
                     522..523,526,581..582,585..586,589..590,592..593,616,
                     618..622,625,628,678,689)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:212594"
     Site            order(287,291,294,331,336,339,980,1026,1078,1094,1107,
                     1164,1168,1178,1262,1269..1270)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212594"
     CDS             1..1328
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /coded_by="XM_047432794.1:170..4156"
                     /db_xref="GeneID:55215"
                     /db_xref="HGNC:HGNC:25568"
                     /db_xref="MIM:611360"
ORIGIN      
        1 mdqkilslaa ektadklqef lqtlregdlt nllqnqavkg kvagallrai fkgspcseea
       61 gtlrrrkiyt cciqlvesgd lqkeiaseii gllmleahhf pgpllvelan efisavregs
      121 lvngkslell piiltalatk kenlaygkgv lsgeeckkql intlcsgrwd qqyviqltsm
      181 fkdvpltaee vefvvekals mfskmnlqei pplvyqllvl sskgsrksvl egiiaffsal
      241 dkqhneeqsg delldvvtvp sgelrhvegt iilhivfaik ldyelgrelv khlkvgqqgd
      301 snnnlspfsi alllsvtriq rfqdqvldll ktsvvksfkd lqllqgskfl qnlvphrsyv
      361 stmilevvkn svhswdhvtq glvelgfilm dsygpkkvld gktietspsl srmpnqhack
      421 lganilletf kihemirqei leqvlnrvvt rasspishfl dllsnivmya plvlqscssk
      481 vteafdylsf lplqtvqrll kavqpllkvs msmrdclilv lrkamfanql darksavagf
      541 llllknfkvl gslsssqcsq slsvsqvhvd vhshynsvan etfcleimds lrrclsqqad
      601 vrlmlyegfy dvlrrnsqla nsvmqtllsq lkqfyepkpd llpplkleac iltqgdkisl
      661 qepldyllcc iqhclawykn tviplqqgee eeeeeeafye dlddilesit nrmikseled
      721 feldksadfs qstsigiknn icaflvmgvc evlieynfsi ssfsknrfed ilslfmcykk
      781 lsdilnekag kaktkmankt sdsllsmkfv sslltalfrd siqshqesls vlrssnefmr
      841 yavnvalqkv qqlketghvs gpdgqnpeki fqnlcditrv llwrytsipt sveesgkkek
      901 gksisllcle glqkifsavq qfyqpkiqqf lraldvtdke geeredadvs vtqrtafqir
      961 qfqrsllnll ssqeedfnsk ealllvtvlt slskllepss pqfvqmlswt skickensre
     1021 dalfckslmn llfslhvsyk spvillrdls qdihghlgdi dqdvevektn hfaivnlrta
     1081 aptvcllvls qaekvleevd wlitklkgqv sqetlseeas sqatlpnqpv ekaiimqlgt
     1141 lltffhelvq talpsgscvd tllkdlckmy ttltalvryy lqvcqssggi pknmeklvkl
     1201 sgshltplcy sfisyvqnks kslnytgekk ekpaavatam arvlretkpi pnlifaieqy
     1261 ekflihlskk skvnlmqhmk lstsrdfkik gnildmvlre dgedeneegt asehggqnke
     1321 pakkkrkk
//
LOCUS       XP_047288751            1328 aa            linear   PRI 05-AUG-2025
DEFINITION  Fanconi anemia group I protein isoform X1 [Homo sapiens].
ACCESSION   XP_047288751
VERSION     XP_047288751.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432795.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1328
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1328
                     /product="Fanconi anemia group I protein isoform X1"
                     /calculated_mol_wt=149193
     Region          1..53
                     /region_name="FANCI_S1-cap"
                     /note="FANCI solenoid 1 cap; pfam14674"
                     /db_xref="CDD:434117"
     Region          43..1290
                     /region_name="FANCI"
                     /note="Fanconi anemia I protein; cd11720"
                     /db_xref="CDD:212594"
     Site            order(48,52,83..84,87,90..91,94..95,98,128,131,182..183,
                     215,219,273,277,280,376,442,446,449,480,483,486..487,490,
                     522..523,526,581..582,585..586,589..590,592..593,616,
                     618..622,625,628,678,689)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:212594"
     Site            order(287,291,294,331,336,339,980,1026,1078,1094,1107,
                     1164,1168,1178,1262,1269..1270)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212594"
     CDS             1..1328
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /coded_by="XM_047432795.1:211..4197"
                     /db_xref="GeneID:55215"
                     /db_xref="HGNC:HGNC:25568"
                     /db_xref="MIM:611360"
ORIGIN      
        1 mdqkilslaa ektadklqef lqtlregdlt nllqnqavkg kvagallrai fkgspcseea
       61 gtlrrrkiyt cciqlvesgd lqkeiaseii gllmleahhf pgpllvelan efisavregs
      121 lvngkslell piiltalatk kenlaygkgv lsgeeckkql intlcsgrwd qqyviqltsm
      181 fkdvpltaee vefvvekals mfskmnlqei pplvyqllvl sskgsrksvl egiiaffsal
      241 dkqhneeqsg delldvvtvp sgelrhvegt iilhivfaik ldyelgrelv khlkvgqqgd
      301 snnnlspfsi alllsvtriq rfqdqvldll ktsvvksfkd lqllqgskfl qnlvphrsyv
      361 stmilevvkn svhswdhvtq glvelgfilm dsygpkkvld gktietspsl srmpnqhack
      421 lganilletf kihemirqei leqvlnrvvt rasspishfl dllsnivmya plvlqscssk
      481 vteafdylsf lplqtvqrll kavqpllkvs msmrdclilv lrkamfanql darksavagf
      541 llllknfkvl gslsssqcsq slsvsqvhvd vhshynsvan etfcleimds lrrclsqqad
      601 vrlmlyegfy dvlrrnsqla nsvmqtllsq lkqfyepkpd llpplkleac iltqgdkisl
      661 qepldyllcc iqhclawykn tviplqqgee eeeeeeafye dlddilesit nrmikseled
      721 feldksadfs qstsigiknn icaflvmgvc evlieynfsi ssfsknrfed ilslfmcykk
      781 lsdilnekag kaktkmankt sdsllsmkfv sslltalfrd siqshqesls vlrssnefmr
      841 yavnvalqkv qqlketghvs gpdgqnpeki fqnlcditrv llwrytsipt sveesgkkek
      901 gksisllcle glqkifsavq qfyqpkiqqf lraldvtdke geeredadvs vtqrtafqir
      961 qfqrsllnll ssqeedfnsk ealllvtvlt slskllepss pqfvqmlswt skickensre
     1021 dalfckslmn llfslhvsyk spvillrdls qdihghlgdi dqdvevektn hfaivnlrta
     1081 aptvcllvls qaekvleevd wlitklkgqv sqetlseeas sqatlpnqpv ekaiimqlgt
     1141 lltffhelvq talpsgscvd tllkdlckmy ttltalvryy lqvcqssggi pknmeklvkl
     1201 sgshltplcy sfisyvqnks kslnytgekk ekpaavatam arvlretkpi pnlifaieqy
     1261 ekflihlskk skvnlmqhmk lstsrdfkik gnildmvlre dgedeneegt asehggqnke
     1321 pakkkrkk
//
LOCUS       XP_047288752            1328 aa            linear   PRI 05-AUG-2025
DEFINITION  Fanconi anemia group I protein isoform X1 [Homo sapiens].
ACCESSION   XP_047288752
VERSION     XP_047288752.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432796.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1328
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1328
                     /product="Fanconi anemia group I protein isoform X1"
                     /calculated_mol_wt=149193
     Region          1..53
                     /region_name="FANCI_S1-cap"
                     /note="FANCI solenoid 1 cap; pfam14674"
                     /db_xref="CDD:434117"
     Region          43..1290
                     /region_name="FANCI"
                     /note="Fanconi anemia I protein; cd11720"
                     /db_xref="CDD:212594"
     Site            order(48,52,83..84,87,90..91,94..95,98,128,131,182..183,
                     215,219,273,277,280,376,442,446,449,480,483,486..487,490,
                     522..523,526,581..582,585..586,589..590,592..593,616,
                     618..622,625,628,678,689)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:212594"
     Site            order(287,291,294,331,336,339,980,1026,1078,1094,1107,
                     1164,1168,1178,1262,1269..1270)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212594"
     CDS             1..1328
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /coded_by="XM_047432796.1:188..4174"
                     /db_xref="GeneID:55215"
                     /db_xref="HGNC:HGNC:25568"
                     /db_xref="MIM:611360"
ORIGIN      
        1 mdqkilslaa ektadklqef lqtlregdlt nllqnqavkg kvagallrai fkgspcseea
       61 gtlrrrkiyt cciqlvesgd lqkeiaseii gllmleahhf pgpllvelan efisavregs
      121 lvngkslell piiltalatk kenlaygkgv lsgeeckkql intlcsgrwd qqyviqltsm
      181 fkdvpltaee vefvvekals mfskmnlqei pplvyqllvl sskgsrksvl egiiaffsal
      241 dkqhneeqsg delldvvtvp sgelrhvegt iilhivfaik ldyelgrelv khlkvgqqgd
      301 snnnlspfsi alllsvtriq rfqdqvldll ktsvvksfkd lqllqgskfl qnlvphrsyv
      361 stmilevvkn svhswdhvtq glvelgfilm dsygpkkvld gktietspsl srmpnqhack
      421 lganilletf kihemirqei leqvlnrvvt rasspishfl dllsnivmya plvlqscssk
      481 vteafdylsf lplqtvqrll kavqpllkvs msmrdclilv lrkamfanql darksavagf
      541 llllknfkvl gslsssqcsq slsvsqvhvd vhshynsvan etfcleimds lrrclsqqad
      601 vrlmlyegfy dvlrrnsqla nsvmqtllsq lkqfyepkpd llpplkleac iltqgdkisl
      661 qepldyllcc iqhclawykn tviplqqgee eeeeeeafye dlddilesit nrmikseled
      721 feldksadfs qstsigiknn icaflvmgvc evlieynfsi ssfsknrfed ilslfmcykk
      781 lsdilnekag kaktkmankt sdsllsmkfv sslltalfrd siqshqesls vlrssnefmr
      841 yavnvalqkv qqlketghvs gpdgqnpeki fqnlcditrv llwrytsipt sveesgkkek
      901 gksisllcle glqkifsavq qfyqpkiqqf lraldvtdke geeredadvs vtqrtafqir
      961 qfqrsllnll ssqeedfnsk ealllvtvlt slskllepss pqfvqmlswt skickensre
     1021 dalfckslmn llfslhvsyk spvillrdls qdihghlgdi dqdvevektn hfaivnlrta
     1081 aptvcllvls qaekvleevd wlitklkgqv sqetlseeas sqatlpnqpv ekaiimqlgt
     1141 lltffhelvq talpsgscvd tllkdlckmy ttltalvryy lqvcqssggi pknmeklvkl
     1201 sgshltplcy sfisyvqnks kslnytgekk ekpaavatam arvlretkpi pnlifaieqy
     1261 ekflihlskk skvnlmqhmk lstsrdfkik gnildmvlre dgedeneegt asehggqnke
     1321 pakkkrkk
//
LOCUS       XP_047288753            1328 aa            linear   PRI 05-AUG-2025
DEFINITION  Fanconi anemia group I protein isoform X1 [Homo sapiens].
ACCESSION   XP_047288753
VERSION     XP_047288753.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432797.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1328
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1328
                     /product="Fanconi anemia group I protein isoform X1"
                     /calculated_mol_wt=149193
     Region          1..53
                     /region_name="FANCI_S1-cap"
                     /note="FANCI solenoid 1 cap; pfam14674"
                     /db_xref="CDD:434117"
     Region          43..1290
                     /region_name="FANCI"
                     /note="Fanconi anemia I protein; cd11720"
                     /db_xref="CDD:212594"
     Site            order(48,52,83..84,87,90..91,94..95,98,128,131,182..183,
                     215,219,273,277,280,376,442,446,449,480,483,486..487,490,
                     522..523,526,581..582,585..586,589..590,592..593,616,
                     618..622,625,628,678,689)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:212594"
     Site            order(287,291,294,331,336,339,980,1026,1078,1094,1107,
                     1164,1168,1178,1262,1269..1270)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212594"
     CDS             1..1328
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /coded_by="XM_047432797.1:234..4220"
                     /db_xref="GeneID:55215"
                     /db_xref="HGNC:HGNC:25568"
                     /db_xref="MIM:611360"
ORIGIN      
        1 mdqkilslaa ektadklqef lqtlregdlt nllqnqavkg kvagallrai fkgspcseea
       61 gtlrrrkiyt cciqlvesgd lqkeiaseii gllmleahhf pgpllvelan efisavregs
      121 lvngkslell piiltalatk kenlaygkgv lsgeeckkql intlcsgrwd qqyviqltsm
      181 fkdvpltaee vefvvekals mfskmnlqei pplvyqllvl sskgsrksvl egiiaffsal
      241 dkqhneeqsg delldvvtvp sgelrhvegt iilhivfaik ldyelgrelv khlkvgqqgd
      301 snnnlspfsi alllsvtriq rfqdqvldll ktsvvksfkd lqllqgskfl qnlvphrsyv
      361 stmilevvkn svhswdhvtq glvelgfilm dsygpkkvld gktietspsl srmpnqhack
      421 lganilletf kihemirqei leqvlnrvvt rasspishfl dllsnivmya plvlqscssk
      481 vteafdylsf lplqtvqrll kavqpllkvs msmrdclilv lrkamfanql darksavagf
      541 llllknfkvl gslsssqcsq slsvsqvhvd vhshynsvan etfcleimds lrrclsqqad
      601 vrlmlyegfy dvlrrnsqla nsvmqtllsq lkqfyepkpd llpplkleac iltqgdkisl
      661 qepldyllcc iqhclawykn tviplqqgee eeeeeeafye dlddilesit nrmikseled
      721 feldksadfs qstsigiknn icaflvmgvc evlieynfsi ssfsknrfed ilslfmcykk
      781 lsdilnekag kaktkmankt sdsllsmkfv sslltalfrd siqshqesls vlrssnefmr
      841 yavnvalqkv qqlketghvs gpdgqnpeki fqnlcditrv llwrytsipt sveesgkkek
      901 gksisllcle glqkifsavq qfyqpkiqqf lraldvtdke geeredadvs vtqrtafqir
      961 qfqrsllnll ssqeedfnsk ealllvtvlt slskllepss pqfvqmlswt skickensre
     1021 dalfckslmn llfslhvsyk spvillrdls qdihghlgdi dqdvevektn hfaivnlrta
     1081 aptvcllvls qaekvleevd wlitklkgqv sqetlseeas sqatlpnqpv ekaiimqlgt
     1141 lltffhelvq talpsgscvd tllkdlckmy ttltalvryy lqvcqssggi pknmeklvkl
     1201 sgshltplcy sfisyvqnks kslnytgekk ekpaavatam arvlretkpi pnlifaieqy
     1261 ekflihlskk skvnlmqhmk lstsrdfkik gnildmvlre dgedeneegt asehggqnke
     1321 pakkkrkk
//
LOCUS       XP_047288754            1328 aa            linear   PRI 05-AUG-2025
DEFINITION  Fanconi anemia group I protein isoform X1 [Homo sapiens].
ACCESSION   XP_047288754
VERSION     XP_047288754.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432798.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1328
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1328
                     /product="Fanconi anemia group I protein isoform X1"
                     /calculated_mol_wt=149193
     Region          1..53
                     /region_name="FANCI_S1-cap"
                     /note="FANCI solenoid 1 cap; pfam14674"
                     /db_xref="CDD:434117"
     Region          43..1290
                     /region_name="FANCI"
                     /note="Fanconi anemia I protein; cd11720"
                     /db_xref="CDD:212594"
     Site            order(48,52,83..84,87,90..91,94..95,98,128,131,182..183,
                     215,219,273,277,280,376,442,446,449,480,483,486..487,490,
                     522..523,526,581..582,585..586,589..590,592..593,616,
                     618..622,625,628,678,689)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:212594"
     Site            order(287,291,294,331,336,339,980,1026,1078,1094,1107,
                     1164,1168,1178,1262,1269..1270)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212594"
     CDS             1..1328
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /coded_by="XM_047432798.1:322..4308"
                     /db_xref="GeneID:55215"
                     /db_xref="HGNC:HGNC:25568"
                     /db_xref="MIM:611360"
ORIGIN      
        1 mdqkilslaa ektadklqef lqtlregdlt nllqnqavkg kvagallrai fkgspcseea
       61 gtlrrrkiyt cciqlvesgd lqkeiaseii gllmleahhf pgpllvelan efisavregs
      121 lvngkslell piiltalatk kenlaygkgv lsgeeckkql intlcsgrwd qqyviqltsm
      181 fkdvpltaee vefvvekals mfskmnlqei pplvyqllvl sskgsrksvl egiiaffsal
      241 dkqhneeqsg delldvvtvp sgelrhvegt iilhivfaik ldyelgrelv khlkvgqqgd
      301 snnnlspfsi alllsvtriq rfqdqvldll ktsvvksfkd lqllqgskfl qnlvphrsyv
      361 stmilevvkn svhswdhvtq glvelgfilm dsygpkkvld gktietspsl srmpnqhack
      421 lganilletf kihemirqei leqvlnrvvt rasspishfl dllsnivmya plvlqscssk
      481 vteafdylsf lplqtvqrll kavqpllkvs msmrdclilv lrkamfanql darksavagf
      541 llllknfkvl gslsssqcsq slsvsqvhvd vhshynsvan etfcleimds lrrclsqqad
      601 vrlmlyegfy dvlrrnsqla nsvmqtllsq lkqfyepkpd llpplkleac iltqgdkisl
      661 qepldyllcc iqhclawykn tviplqqgee eeeeeeafye dlddilesit nrmikseled
      721 feldksadfs qstsigiknn icaflvmgvc evlieynfsi ssfsknrfed ilslfmcykk
      781 lsdilnekag kaktkmankt sdsllsmkfv sslltalfrd siqshqesls vlrssnefmr
      841 yavnvalqkv qqlketghvs gpdgqnpeki fqnlcditrv llwrytsipt sveesgkkek
      901 gksisllcle glqkifsavq qfyqpkiqqf lraldvtdke geeredadvs vtqrtafqir
      961 qfqrsllnll ssqeedfnsk ealllvtvlt slskllepss pqfvqmlswt skickensre
     1021 dalfckslmn llfslhvsyk spvillrdls qdihghlgdi dqdvevektn hfaivnlrta
     1081 aptvcllvls qaekvleevd wlitklkgqv sqetlseeas sqatlpnqpv ekaiimqlgt
     1141 lltffhelvq talpsgscvd tllkdlckmy ttltalvryy lqvcqssggi pknmeklvkl
     1201 sgshltplcy sfisyvqnks kslnytgekk ekpaavatam arvlretkpi pnlifaieqy
     1261 ekflihlskk skvnlmqhmk lstsrdfkik gnildmvlre dgedeneegt asehggqnke
     1321 pakkkrkk
//
LOCUS       XP_047288755            1328 aa            linear   PRI 05-AUG-2025
DEFINITION  Fanconi anemia group I protein isoform X1 [Homo sapiens].
ACCESSION   XP_047288755
VERSION     XP_047288755.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432799.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1328
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1328
                     /product="Fanconi anemia group I protein isoform X1"
                     /calculated_mol_wt=149193
     Region          1..53
                     /region_name="FANCI_S1-cap"
                     /note="FANCI solenoid 1 cap; pfam14674"
                     /db_xref="CDD:434117"
     Region          43..1290
                     /region_name="FANCI"
                     /note="Fanconi anemia I protein; cd11720"
                     /db_xref="CDD:212594"
     Site            order(48,52,83..84,87,90..91,94..95,98,128,131,182..183,
                     215,219,273,277,280,376,442,446,449,480,483,486..487,490,
                     522..523,526,581..582,585..586,589..590,592..593,616,
                     618..622,625,628,678,689)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:212594"
     Site            order(287,291,294,331,336,339,980,1026,1078,1094,1107,
                     1164,1168,1178,1262,1269..1270)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212594"
     CDS             1..1328
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /coded_by="XM_047432799.1:319..4305"
                     /db_xref="GeneID:55215"
                     /db_xref="HGNC:HGNC:25568"
                     /db_xref="MIM:611360"
ORIGIN      
        1 mdqkilslaa ektadklqef lqtlregdlt nllqnqavkg kvagallrai fkgspcseea
       61 gtlrrrkiyt cciqlvesgd lqkeiaseii gllmleahhf pgpllvelan efisavregs
      121 lvngkslell piiltalatk kenlaygkgv lsgeeckkql intlcsgrwd qqyviqltsm
      181 fkdvpltaee vefvvekals mfskmnlqei pplvyqllvl sskgsrksvl egiiaffsal
      241 dkqhneeqsg delldvvtvp sgelrhvegt iilhivfaik ldyelgrelv khlkvgqqgd
      301 snnnlspfsi alllsvtriq rfqdqvldll ktsvvksfkd lqllqgskfl qnlvphrsyv
      361 stmilevvkn svhswdhvtq glvelgfilm dsygpkkvld gktietspsl srmpnqhack
      421 lganilletf kihemirqei leqvlnrvvt rasspishfl dllsnivmya plvlqscssk
      481 vteafdylsf lplqtvqrll kavqpllkvs msmrdclilv lrkamfanql darksavagf
      541 llllknfkvl gslsssqcsq slsvsqvhvd vhshynsvan etfcleimds lrrclsqqad
      601 vrlmlyegfy dvlrrnsqla nsvmqtllsq lkqfyepkpd llpplkleac iltqgdkisl
      661 qepldyllcc iqhclawykn tviplqqgee eeeeeeafye dlddilesit nrmikseled
      721 feldksadfs qstsigiknn icaflvmgvc evlieynfsi ssfsknrfed ilslfmcykk
      781 lsdilnekag kaktkmankt sdsllsmkfv sslltalfrd siqshqesls vlrssnefmr
      841 yavnvalqkv qqlketghvs gpdgqnpeki fqnlcditrv llwrytsipt sveesgkkek
      901 gksisllcle glqkifsavq qfyqpkiqqf lraldvtdke geeredadvs vtqrtafqir
      961 qfqrsllnll ssqeedfnsk ealllvtvlt slskllepss pqfvqmlswt skickensre
     1021 dalfckslmn llfslhvsyk spvillrdls qdihghlgdi dqdvevektn hfaivnlrta
     1081 aptvcllvls qaekvleevd wlitklkgqv sqetlseeas sqatlpnqpv ekaiimqlgt
     1141 lltffhelvq talpsgscvd tllkdlckmy ttltalvryy lqvcqssggi pknmeklvkl
     1201 sgshltplcy sfisyvqnks kslnytgekk ekpaavatam arvlretkpi pnlifaieqy
     1261 ekflihlskk skvnlmqhmk lstsrdfkik gnildmvlre dgedeneegt asehggqnke
     1321 pakkkrkk
//
LOCUS       XP_047288756            1328 aa            linear   PRI 05-AUG-2025
DEFINITION  Fanconi anemia group I protein isoform X1 [Homo sapiens].
ACCESSION   XP_047288756
VERSION     XP_047288756.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432800.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1328
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1328
                     /product="Fanconi anemia group I protein isoform X1"
                     /calculated_mol_wt=149193
     Region          1..53
                     /region_name="FANCI_S1-cap"
                     /note="FANCI solenoid 1 cap; pfam14674"
                     /db_xref="CDD:434117"
     Region          43..1290
                     /region_name="FANCI"
                     /note="Fanconi anemia I protein; cd11720"
                     /db_xref="CDD:212594"
     Site            order(48,52,83..84,87,90..91,94..95,98,128,131,182..183,
                     215,219,273,277,280,376,442,446,449,480,483,486..487,490,
                     522..523,526,581..582,585..586,589..590,592..593,616,
                     618..622,625,628,678,689)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:212594"
     Site            order(287,291,294,331,336,339,980,1026,1078,1094,1107,
                     1164,1168,1178,1262,1269..1270)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212594"
     CDS             1..1328
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /coded_by="XM_047432800.1:342..4328"
                     /db_xref="GeneID:55215"
                     /db_xref="HGNC:HGNC:25568"
                     /db_xref="MIM:611360"
ORIGIN      
        1 mdqkilslaa ektadklqef lqtlregdlt nllqnqavkg kvagallrai fkgspcseea
       61 gtlrrrkiyt cciqlvesgd lqkeiaseii gllmleahhf pgpllvelan efisavregs
      121 lvngkslell piiltalatk kenlaygkgv lsgeeckkql intlcsgrwd qqyviqltsm
      181 fkdvpltaee vefvvekals mfskmnlqei pplvyqllvl sskgsrksvl egiiaffsal
      241 dkqhneeqsg delldvvtvp sgelrhvegt iilhivfaik ldyelgrelv khlkvgqqgd
      301 snnnlspfsi alllsvtriq rfqdqvldll ktsvvksfkd lqllqgskfl qnlvphrsyv
      361 stmilevvkn svhswdhvtq glvelgfilm dsygpkkvld gktietspsl srmpnqhack
      421 lganilletf kihemirqei leqvlnrvvt rasspishfl dllsnivmya plvlqscssk
      481 vteafdylsf lplqtvqrll kavqpllkvs msmrdclilv lrkamfanql darksavagf
      541 llllknfkvl gslsssqcsq slsvsqvhvd vhshynsvan etfcleimds lrrclsqqad
      601 vrlmlyegfy dvlrrnsqla nsvmqtllsq lkqfyepkpd llpplkleac iltqgdkisl
      661 qepldyllcc iqhclawykn tviplqqgee eeeeeeafye dlddilesit nrmikseled
      721 feldksadfs qstsigiknn icaflvmgvc evlieynfsi ssfsknrfed ilslfmcykk
      781 lsdilnekag kaktkmankt sdsllsmkfv sslltalfrd siqshqesls vlrssnefmr
      841 yavnvalqkv qqlketghvs gpdgqnpeki fqnlcditrv llwrytsipt sveesgkkek
      901 gksisllcle glqkifsavq qfyqpkiqqf lraldvtdke geeredadvs vtqrtafqir
      961 qfqrsllnll ssqeedfnsk ealllvtvlt slskllepss pqfvqmlswt skickensre
     1021 dalfckslmn llfslhvsyk spvillrdls qdihghlgdi dqdvevektn hfaivnlrta
     1081 aptvcllvls qaekvleevd wlitklkgqv sqetlseeas sqatlpnqpv ekaiimqlgt
     1141 lltffhelvq talpsgscvd tllkdlckmy ttltalvryy lqvcqssggi pknmeklvkl
     1201 sgshltplcy sfisyvqnks kslnytgekk ekpaavatam arvlretkpi pnlifaieqy
     1261 ekflihlskk skvnlmqhmk lstsrdfkik gnildmvlre dgedeneegt asehggqnke
     1321 pakkkrkk
//
LOCUS       XP_047288757            1328 aa            linear   PRI 05-AUG-2025
DEFINITION  Fanconi anemia group I protein isoform X1 [Homo sapiens].
ACCESSION   XP_047288757
VERSION     XP_047288757.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432801.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1328
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1328
                     /product="Fanconi anemia group I protein isoform X1"
                     /calculated_mol_wt=149193
     Region          1..53
                     /region_name="FANCI_S1-cap"
                     /note="FANCI solenoid 1 cap; pfam14674"
                     /db_xref="CDD:434117"
     Region          43..1290
                     /region_name="FANCI"
                     /note="Fanconi anemia I protein; cd11720"
                     /db_xref="CDD:212594"
     Site            order(48,52,83..84,87,90..91,94..95,98,128,131,182..183,
                     215,219,273,277,280,376,442,446,449,480,483,486..487,490,
                     522..523,526,581..582,585..586,589..590,592..593,616,
                     618..622,625,628,678,689)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:212594"
     Site            order(287,291,294,331,336,339,980,1026,1078,1094,1107,
                     1164,1168,1178,1262,1269..1270)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212594"
     CDS             1..1328
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /coded_by="XM_047432801.1:308..4294"
                     /db_xref="GeneID:55215"
                     /db_xref="HGNC:HGNC:25568"
                     /db_xref="MIM:611360"
ORIGIN      
        1 mdqkilslaa ektadklqef lqtlregdlt nllqnqavkg kvagallrai fkgspcseea
       61 gtlrrrkiyt cciqlvesgd lqkeiaseii gllmleahhf pgpllvelan efisavregs
      121 lvngkslell piiltalatk kenlaygkgv lsgeeckkql intlcsgrwd qqyviqltsm
      181 fkdvpltaee vefvvekals mfskmnlqei pplvyqllvl sskgsrksvl egiiaffsal
      241 dkqhneeqsg delldvvtvp sgelrhvegt iilhivfaik ldyelgrelv khlkvgqqgd
      301 snnnlspfsi alllsvtriq rfqdqvldll ktsvvksfkd lqllqgskfl qnlvphrsyv
      361 stmilevvkn svhswdhvtq glvelgfilm dsygpkkvld gktietspsl srmpnqhack
      421 lganilletf kihemirqei leqvlnrvvt rasspishfl dllsnivmya plvlqscssk
      481 vteafdylsf lplqtvqrll kavqpllkvs msmrdclilv lrkamfanql darksavagf
      541 llllknfkvl gslsssqcsq slsvsqvhvd vhshynsvan etfcleimds lrrclsqqad
      601 vrlmlyegfy dvlrrnsqla nsvmqtllsq lkqfyepkpd llpplkleac iltqgdkisl
      661 qepldyllcc iqhclawykn tviplqqgee eeeeeeafye dlddilesit nrmikseled
      721 feldksadfs qstsigiknn icaflvmgvc evlieynfsi ssfsknrfed ilslfmcykk
      781 lsdilnekag kaktkmankt sdsllsmkfv sslltalfrd siqshqesls vlrssnefmr
      841 yavnvalqkv qqlketghvs gpdgqnpeki fqnlcditrv llwrytsipt sveesgkkek
      901 gksisllcle glqkifsavq qfyqpkiqqf lraldvtdke geeredadvs vtqrtafqir
      961 qfqrsllnll ssqeedfnsk ealllvtvlt slskllepss pqfvqmlswt skickensre
     1021 dalfckslmn llfslhvsyk spvillrdls qdihghlgdi dqdvevektn hfaivnlrta
     1081 aptvcllvls qaekvleevd wlitklkgqv sqetlseeas sqatlpnqpv ekaiimqlgt
     1141 lltffhelvq talpsgscvd tllkdlckmy ttltalvryy lqvcqssggi pknmeklvkl
     1201 sgshltplcy sfisyvqnks kslnytgekk ekpaavatam arvlretkpi pnlifaieqy
     1261 ekflihlskk skvnlmqhmk lstsrdfkik gnildmvlre dgedeneegt asehggqnke
     1321 pakkkrkk
//
LOCUS       XP_047288758            1314 aa            linear   PRI 05-AUG-2025
DEFINITION  Fanconi anemia group I protein isoform X2 [Homo sapiens].
ACCESSION   XP_047288758
VERSION     XP_047288758.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432802.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1314
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1314
                     /product="Fanconi anemia group I protein isoform X2"
                     /calculated_mol_wt=147613
     Region          1..53
                     /region_name="FANCI_S1-cap"
                     /note="FANCI solenoid 1 cap; pfam14674"
                     /db_xref="CDD:434117"
     Region          43..1276
                     /region_name="FANCI"
                     /note="Fanconi anemia I protein; cd11720"
                     /db_xref="CDD:212594"
     Site            order(48,52,83..84,87,90..91,94..95,98,128,131,182..183,
                     215,219,273,277,280,376,442,446,449,480,483,486..487,490,
                     522..523,526,581..582,585..586,589..590,592..593,616,
                     618..622,625,628,678,689)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:212594"
     Site            order(287,291,294,331,336,339,966,1012,1064,1080,1093,
                     1150,1154,1164,1248,1255..1256)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212594"
     CDS             1..1314
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /coded_by="XM_047432802.1:109..4053"
                     /db_xref="GeneID:55215"
                     /db_xref="HGNC:HGNC:25568"
                     /db_xref="MIM:611360"
ORIGIN      
        1 mdqkilslaa ektadklqef lqtlregdlt nllqnqavkg kvagallrai fkgspcseea
       61 gtlrrrkiyt cciqlvesgd lqkeiaseii gllmleahhf pgpllvelan efisavregs
      121 lvngkslell piiltalatk kenlaygkgv lsgeeckkql intlcsgrwd qqyviqltsm
      181 fkdvpltaee vefvvekals mfskmnlqei pplvyqllvl sskgsrksvl egiiaffsal
      241 dkqhneeqsg delldvvtvp sgelrhvegt iilhivfaik ldyelgrelv khlkvgqqgd
      301 snnnlspfsi alllsvtriq rfqdqvldll ktsvvksfkd lqllqgskfl qnlvphrsyv
      361 stmilevvkn svhswdhvtq glvelgfilm dsygpkkvld gktietspsl srmpnqhack
      421 lganilletf kihemirqei leqvlnrvvt rasspishfl dllsnivmya plvlqscssk
      481 vteafdylsf lplqtvqrll kavqpllkvs msmrdclilv lrkamfanql darksavagf
      541 llllknfkvl gslsssqcsq slsvsqvhvd vhshynsvan etfcleimds lrrclsqqad
      601 vrlmlyegfy dvlrrnsqla nsvmqtllsq lkqfyepkpd llpplkleac iltqgdkisl
      661 qepldyllcc iqhclawykn tviplqqgee eeeeeeafye dlddilesit nrmikseled
      721 feldksadfs qstsigiknn icaflvmgvc evlieynfsi ssfsknrfed ilslfmcykk
      781 lsdilnekag kaktkmankt sdsllsmkfv sslltalfrs snefmryavn valqkvqqlk
      841 etghvsgpdg qnpekifqnl cditrvllwr ytsiptsvee sgkkekgksi sllcleglqk
      901 ifsavqqfyq pkiqqflral dvtdkegeer edadvsvtqr tafqirqfqr sllnllssqe
      961 edfnskeall lvtvltslsk llepsspqfv qmlswtskic kensredalf ckslmnllfs
     1021 lhvsykspvi llrdlsqdih ghlgdidqdv evektnhfai vnlrtaaptv cllvlsqaek
     1081 vleevdwlit klkgqvsqet lseeassqat lpnqpvekai imqlgtlltf fhelvqtalp
     1141 sgscvdtllk dlckmyttlt alvryylqvc qssggipknm eklvklsgsh ltplcysfis
     1201 yvqnksksln ytgekkekpa avatamarvl retkpipnli faieqyekfl ihlskkskvn
     1261 lmqhmklsts rdfkikgnil dmvlredged eneegtaseh ggqnkepakk krkk
//
LOCUS       XP_047288759            1314 aa            linear   PRI 05-AUG-2025
DEFINITION  Fanconi anemia group I protein isoform X2 [Homo sapiens].
ACCESSION   XP_047288759
VERSION     XP_047288759.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432803.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1314
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1314
                     /product="Fanconi anemia group I protein isoform X2"
                     /calculated_mol_wt=147613
     Region          1..53
                     /region_name="FANCI_S1-cap"
                     /note="FANCI solenoid 1 cap; pfam14674"
                     /db_xref="CDD:434117"
     Region          43..1276
                     /region_name="FANCI"
                     /note="Fanconi anemia I protein; cd11720"
                     /db_xref="CDD:212594"
     Site            order(48,52,83..84,87,90..91,94..95,98,128,131,182..183,
                     215,219,273,277,280,376,442,446,449,480,483,486..487,490,
                     522..523,526,581..582,585..586,589..590,592..593,616,
                     618..622,625,628,678,689)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:212594"
     Site            order(287,291,294,331,336,339,966,1012,1064,1080,1093,
                     1150,1154,1164,1248,1255..1256)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212594"
     CDS             1..1314
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /coded_by="XM_047432803.1:75..4019"
                     /db_xref="GeneID:55215"
                     /db_xref="HGNC:HGNC:25568"
                     /db_xref="MIM:611360"
ORIGIN      
        1 mdqkilslaa ektadklqef lqtlregdlt nllqnqavkg kvagallrai fkgspcseea
       61 gtlrrrkiyt cciqlvesgd lqkeiaseii gllmleahhf pgpllvelan efisavregs
      121 lvngkslell piiltalatk kenlaygkgv lsgeeckkql intlcsgrwd qqyviqltsm
      181 fkdvpltaee vefvvekals mfskmnlqei pplvyqllvl sskgsrksvl egiiaffsal
      241 dkqhneeqsg delldvvtvp sgelrhvegt iilhivfaik ldyelgrelv khlkvgqqgd
      301 snnnlspfsi alllsvtriq rfqdqvldll ktsvvksfkd lqllqgskfl qnlvphrsyv
      361 stmilevvkn svhswdhvtq glvelgfilm dsygpkkvld gktietspsl srmpnqhack
      421 lganilletf kihemirqei leqvlnrvvt rasspishfl dllsnivmya plvlqscssk
      481 vteafdylsf lplqtvqrll kavqpllkvs msmrdclilv lrkamfanql darksavagf
      541 llllknfkvl gslsssqcsq slsvsqvhvd vhshynsvan etfcleimds lrrclsqqad
      601 vrlmlyegfy dvlrrnsqla nsvmqtllsq lkqfyepkpd llpplkleac iltqgdkisl
      661 qepldyllcc iqhclawykn tviplqqgee eeeeeeafye dlddilesit nrmikseled
      721 feldksadfs qstsigiknn icaflvmgvc evlieynfsi ssfsknrfed ilslfmcykk
      781 lsdilnekag kaktkmankt sdsllsmkfv sslltalfrs snefmryavn valqkvqqlk
      841 etghvsgpdg qnpekifqnl cditrvllwr ytsiptsvee sgkkekgksi sllcleglqk
      901 ifsavqqfyq pkiqqflral dvtdkegeer edadvsvtqr tafqirqfqr sllnllssqe
      961 edfnskeall lvtvltslsk llepsspqfv qmlswtskic kensredalf ckslmnllfs
     1021 lhvsykspvi llrdlsqdih ghlgdidqdv evektnhfai vnlrtaaptv cllvlsqaek
     1081 vleevdwlit klkgqvsqet lseeassqat lpnqpvekai imqlgtlltf fhelvqtalp
     1141 sgscvdtllk dlckmyttlt alvryylqvc qssggipknm eklvklsgsh ltplcysfis
     1201 yvqnksksln ytgekkekpa avatamarvl retkpipnli faieqyekfl ihlskkskvn
     1261 lmqhmklsts rdfkikgnil dmvlredged eneegtaseh ggqnkepakk krkk
//
LOCUS       XP_047288760            1314 aa            linear   PRI 05-AUG-2025
DEFINITION  Fanconi anemia group I protein isoform X2 [Homo sapiens].
ACCESSION   XP_047288760
VERSION     XP_047288760.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432804.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1314
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1314
                     /product="Fanconi anemia group I protein isoform X2"
                     /calculated_mol_wt=147613
     Region          1..53
                     /region_name="FANCI_S1-cap"
                     /note="FANCI solenoid 1 cap; pfam14674"
                     /db_xref="CDD:434117"
     Region          43..1276
                     /region_name="FANCI"
                     /note="Fanconi anemia I protein; cd11720"
                     /db_xref="CDD:212594"
     Site            order(48,52,83..84,87,90..91,94..95,98,128,131,182..183,
                     215,219,273,277,280,376,442,446,449,480,483,486..487,490,
                     522..523,526,581..582,585..586,589..590,592..593,616,
                     618..622,625,628,678,689)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:212594"
     Site            order(287,291,294,331,336,339,966,1012,1064,1080,1093,
                     1150,1154,1164,1248,1255..1256)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212594"
     CDS             1..1314
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /coded_by="XM_047432804.1:86..4030"
                     /db_xref="GeneID:55215"
                     /db_xref="HGNC:HGNC:25568"
                     /db_xref="MIM:611360"
ORIGIN      
        1 mdqkilslaa ektadklqef lqtlregdlt nllqnqavkg kvagallrai fkgspcseea
       61 gtlrrrkiyt cciqlvesgd lqkeiaseii gllmleahhf pgpllvelan efisavregs
      121 lvngkslell piiltalatk kenlaygkgv lsgeeckkql intlcsgrwd qqyviqltsm
      181 fkdvpltaee vefvvekals mfskmnlqei pplvyqllvl sskgsrksvl egiiaffsal
      241 dkqhneeqsg delldvvtvp sgelrhvegt iilhivfaik ldyelgrelv khlkvgqqgd
      301 snnnlspfsi alllsvtriq rfqdqvldll ktsvvksfkd lqllqgskfl qnlvphrsyv
      361 stmilevvkn svhswdhvtq glvelgfilm dsygpkkvld gktietspsl srmpnqhack
      421 lganilletf kihemirqei leqvlnrvvt rasspishfl dllsnivmya plvlqscssk
      481 vteafdylsf lplqtvqrll kavqpllkvs msmrdclilv lrkamfanql darksavagf
      541 llllknfkvl gslsssqcsq slsvsqvhvd vhshynsvan etfcleimds lrrclsqqad
      601 vrlmlyegfy dvlrrnsqla nsvmqtllsq lkqfyepkpd llpplkleac iltqgdkisl
      661 qepldyllcc iqhclawykn tviplqqgee eeeeeeafye dlddilesit nrmikseled
      721 feldksadfs qstsigiknn icaflvmgvc evlieynfsi ssfsknrfed ilslfmcykk
      781 lsdilnekag kaktkmankt sdsllsmkfv sslltalfrs snefmryavn valqkvqqlk
      841 etghvsgpdg qnpekifqnl cditrvllwr ytsiptsvee sgkkekgksi sllcleglqk
      901 ifsavqqfyq pkiqqflral dvtdkegeer edadvsvtqr tafqirqfqr sllnllssqe
      961 edfnskeall lvtvltslsk llepsspqfv qmlswtskic kensredalf ckslmnllfs
     1021 lhvsykspvi llrdlsqdih ghlgdidqdv evektnhfai vnlrtaaptv cllvlsqaek
     1081 vleevdwlit klkgqvsqet lseeassqat lpnqpvekai imqlgtlltf fhelvqtalp
     1141 sgscvdtllk dlckmyttlt alvryylqvc qssggipknm eklvklsgsh ltplcysfis
     1201 yvqnksksln ytgekkekpa avatamarvl retkpipnli faieqyekfl ihlskkskvn
     1261 lmqhmklsts rdfkikgnil dmvlredged eneegtaseh ggqnkepakk krkk
//
LOCUS       XP_047288761            1314 aa            linear   PRI 05-AUG-2025
DEFINITION  Fanconi anemia group I protein isoform X2 [Homo sapiens].
ACCESSION   XP_047288761
VERSION     XP_047288761.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432805.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1314
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1314
                     /product="Fanconi anemia group I protein isoform X2"
                     /calculated_mol_wt=147613
     Region          1..53
                     /region_name="FANCI_S1-cap"
                     /note="FANCI solenoid 1 cap; pfam14674"
                     /db_xref="CDD:434117"
     Region          43..1276
                     /region_name="FANCI"
                     /note="Fanconi anemia I protein; cd11720"
                     /db_xref="CDD:212594"
     Site            order(48,52,83..84,87,90..91,94..95,98,128,131,182..183,
                     215,219,273,277,280,376,442,446,449,480,483,486..487,490,
                     522..523,526,581..582,585..586,589..590,592..593,616,
                     618..622,625,628,678,689)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:212594"
     Site            order(287,291,294,331,336,339,966,1012,1064,1080,1093,
                     1150,1154,1164,1248,1255..1256)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212594"
     CDS             1..1314
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /coded_by="XM_047432805.1:1891..5835"
                     /db_xref="GeneID:55215"
                     /db_xref="HGNC:HGNC:25568"
                     /db_xref="MIM:611360"
ORIGIN      
        1 mdqkilslaa ektadklqef lqtlregdlt nllqnqavkg kvagallrai fkgspcseea
       61 gtlrrrkiyt cciqlvesgd lqkeiaseii gllmleahhf pgpllvelan efisavregs
      121 lvngkslell piiltalatk kenlaygkgv lsgeeckkql intlcsgrwd qqyviqltsm
      181 fkdvpltaee vefvvekals mfskmnlqei pplvyqllvl sskgsrksvl egiiaffsal
      241 dkqhneeqsg delldvvtvp sgelrhvegt iilhivfaik ldyelgrelv khlkvgqqgd
      301 snnnlspfsi alllsvtriq rfqdqvldll ktsvvksfkd lqllqgskfl qnlvphrsyv
      361 stmilevvkn svhswdhvtq glvelgfilm dsygpkkvld gktietspsl srmpnqhack
      421 lganilletf kihemirqei leqvlnrvvt rasspishfl dllsnivmya plvlqscssk
      481 vteafdylsf lplqtvqrll kavqpllkvs msmrdclilv lrkamfanql darksavagf
      541 llllknfkvl gslsssqcsq slsvsqvhvd vhshynsvan etfcleimds lrrclsqqad
      601 vrlmlyegfy dvlrrnsqla nsvmqtllsq lkqfyepkpd llpplkleac iltqgdkisl
      661 qepldyllcc iqhclawykn tviplqqgee eeeeeeafye dlddilesit nrmikseled
      721 feldksadfs qstsigiknn icaflvmgvc evlieynfsi ssfsknrfed ilslfmcykk
      781 lsdilnekag kaktkmankt sdsllsmkfv sslltalfrs snefmryavn valqkvqqlk
      841 etghvsgpdg qnpekifqnl cditrvllwr ytsiptsvee sgkkekgksi sllcleglqk
      901 ifsavqqfyq pkiqqflral dvtdkegeer edadvsvtqr tafqirqfqr sllnllssqe
      961 edfnskeall lvtvltslsk llepsspqfv qmlswtskic kensredalf ckslmnllfs
     1021 lhvsykspvi llrdlsqdih ghlgdidqdv evektnhfai vnlrtaaptv cllvlsqaek
     1081 vleevdwlit klkgqvsqet lseeassqat lpnqpvekai imqlgtlltf fhelvqtalp
     1141 sgscvdtllk dlckmyttlt alvryylqvc qssggipknm eklvklsgsh ltplcysfis
     1201 yvqnksksln ytgekkekpa avatamarvl retkpipnli faieqyekfl ihlskkskvn
     1261 lmqhmklsts rdfkikgnil dmvlredged eneegtaseh ggqnkepakk krkk
//
LOCUS       XP_047288762            1314 aa            linear   PRI 05-AUG-2025
DEFINITION  Fanconi anemia group I protein isoform X2 [Homo sapiens].
ACCESSION   XP_047288762
VERSION     XP_047288762.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432806.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1314
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1314
                     /product="Fanconi anemia group I protein isoform X2"
                     /calculated_mol_wt=147613
     Region          1..53
                     /region_name="FANCI_S1-cap"
                     /note="FANCI solenoid 1 cap; pfam14674"
                     /db_xref="CDD:434117"
     Region          43..1276
                     /region_name="FANCI"
                     /note="Fanconi anemia I protein; cd11720"
                     /db_xref="CDD:212594"
     Site            order(48,52,83..84,87,90..91,94..95,98,128,131,182..183,
                     215,219,273,277,280,376,442,446,449,480,483,486..487,490,
                     522..523,526,581..582,585..586,589..590,592..593,616,
                     618..622,625,628,678,689)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:212594"
     Site            order(287,291,294,331,336,339,966,1012,1064,1080,1093,
                     1150,1154,1164,1248,1255..1256)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212594"
     CDS             1..1314
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /coded_by="XM_047432806.1:1353..5297"
                     /db_xref="GeneID:55215"
                     /db_xref="HGNC:HGNC:25568"
                     /db_xref="MIM:611360"
ORIGIN      
        1 mdqkilslaa ektadklqef lqtlregdlt nllqnqavkg kvagallrai fkgspcseea
       61 gtlrrrkiyt cciqlvesgd lqkeiaseii gllmleahhf pgpllvelan efisavregs
      121 lvngkslell piiltalatk kenlaygkgv lsgeeckkql intlcsgrwd qqyviqltsm
      181 fkdvpltaee vefvvekals mfskmnlqei pplvyqllvl sskgsrksvl egiiaffsal
      241 dkqhneeqsg delldvvtvp sgelrhvegt iilhivfaik ldyelgrelv khlkvgqqgd
      301 snnnlspfsi alllsvtriq rfqdqvldll ktsvvksfkd lqllqgskfl qnlvphrsyv
      361 stmilevvkn svhswdhvtq glvelgfilm dsygpkkvld gktietspsl srmpnqhack
      421 lganilletf kihemirqei leqvlnrvvt rasspishfl dllsnivmya plvlqscssk
      481 vteafdylsf lplqtvqrll kavqpllkvs msmrdclilv lrkamfanql darksavagf
      541 llllknfkvl gslsssqcsq slsvsqvhvd vhshynsvan etfcleimds lrrclsqqad
      601 vrlmlyegfy dvlrrnsqla nsvmqtllsq lkqfyepkpd llpplkleac iltqgdkisl
      661 qepldyllcc iqhclawykn tviplqqgee eeeeeeafye dlddilesit nrmikseled
      721 feldksadfs qstsigiknn icaflvmgvc evlieynfsi ssfsknrfed ilslfmcykk
      781 lsdilnekag kaktkmankt sdsllsmkfv sslltalfrs snefmryavn valqkvqqlk
      841 etghvsgpdg qnpekifqnl cditrvllwr ytsiptsvee sgkkekgksi sllcleglqk
      901 ifsavqqfyq pkiqqflral dvtdkegeer edadvsvtqr tafqirqfqr sllnllssqe
      961 edfnskeall lvtvltslsk llepsspqfv qmlswtskic kensredalf ckslmnllfs
     1021 lhvsykspvi llrdlsqdih ghlgdidqdv evektnhfai vnlrtaaptv cllvlsqaek
     1081 vleevdwlit klkgqvsqet lseeassqat lpnqpvekai imqlgtlltf fhelvqtalp
     1141 sgscvdtllk dlckmyttlt alvryylqvc qssggipknm eklvklsgsh ltplcysfis
     1201 yvqnksksln ytgekkekpa avatamarvl retkpipnli faieqyekfl ihlskkskvn
     1261 lmqhmklsts rdfkikgnil dmvlredged eneegtaseh ggqnkepakk krkk
//
LOCUS       XP_047288763            1314 aa            linear   PRI 05-AUG-2025
DEFINITION  Fanconi anemia group I protein isoform X2 [Homo sapiens].
ACCESSION   XP_047288763
VERSION     XP_047288763.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432807.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1314
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1314
                     /product="Fanconi anemia group I protein isoform X2"
                     /calculated_mol_wt=147613
     Region          1..53
                     /region_name="FANCI_S1-cap"
                     /note="FANCI solenoid 1 cap; pfam14674"
                     /db_xref="CDD:434117"
     Region          43..1276
                     /region_name="FANCI"
                     /note="Fanconi anemia I protein; cd11720"
                     /db_xref="CDD:212594"
     Site            order(48,52,83..84,87,90..91,94..95,98,128,131,182..183,
                     215,219,273,277,280,376,442,446,449,480,483,486..487,490,
                     522..523,526,581..582,585..586,589..590,592..593,616,
                     618..622,625,628,678,689)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:212594"
     Site            order(287,291,294,331,336,339,966,1012,1064,1080,1093,
                     1150,1154,1164,1248,1255..1256)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212594"
     CDS             1..1314
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /coded_by="XM_047432807.1:159..4103"
                     /db_xref="GeneID:55215"
                     /db_xref="HGNC:HGNC:25568"
                     /db_xref="MIM:611360"
ORIGIN      
        1 mdqkilslaa ektadklqef lqtlregdlt nllqnqavkg kvagallrai fkgspcseea
       61 gtlrrrkiyt cciqlvesgd lqkeiaseii gllmleahhf pgpllvelan efisavregs
      121 lvngkslell piiltalatk kenlaygkgv lsgeeckkql intlcsgrwd qqyviqltsm
      181 fkdvpltaee vefvvekals mfskmnlqei pplvyqllvl sskgsrksvl egiiaffsal
      241 dkqhneeqsg delldvvtvp sgelrhvegt iilhivfaik ldyelgrelv khlkvgqqgd
      301 snnnlspfsi alllsvtriq rfqdqvldll ktsvvksfkd lqllqgskfl qnlvphrsyv
      361 stmilevvkn svhswdhvtq glvelgfilm dsygpkkvld gktietspsl srmpnqhack
      421 lganilletf kihemirqei leqvlnrvvt rasspishfl dllsnivmya plvlqscssk
      481 vteafdylsf lplqtvqrll kavqpllkvs msmrdclilv lrkamfanql darksavagf
      541 llllknfkvl gslsssqcsq slsvsqvhvd vhshynsvan etfcleimds lrrclsqqad
      601 vrlmlyegfy dvlrrnsqla nsvmqtllsq lkqfyepkpd llpplkleac iltqgdkisl
      661 qepldyllcc iqhclawykn tviplqqgee eeeeeeafye dlddilesit nrmikseled
      721 feldksadfs qstsigiknn icaflvmgvc evlieynfsi ssfsknrfed ilslfmcykk
      781 lsdilnekag kaktkmankt sdsllsmkfv sslltalfrs snefmryavn valqkvqqlk
      841 etghvsgpdg qnpekifqnl cditrvllwr ytsiptsvee sgkkekgksi sllcleglqk
      901 ifsavqqfyq pkiqqflral dvtdkegeer edadvsvtqr tafqirqfqr sllnllssqe
      961 edfnskeall lvtvltslsk llepsspqfv qmlswtskic kensredalf ckslmnllfs
     1021 lhvsykspvi llrdlsqdih ghlgdidqdv evektnhfai vnlrtaaptv cllvlsqaek
     1081 vleevdwlit klkgqvsqet lseeassqat lpnqpvekai imqlgtlltf fhelvqtalp
     1141 sgscvdtllk dlckmyttlt alvryylqvc qssggipknm eklvklsgsh ltplcysfis
     1201 yvqnksksln ytgekkekpa avatamarvl retkpipnli faieqyekfl ihlskkskvn
     1261 lmqhmklsts rdfkikgnil dmvlredged eneegtaseh ggqnkepakk krkk
//
LOCUS       XP_047288764            1314 aa            linear   PRI 05-AUG-2025
DEFINITION  Fanconi anemia group I protein isoform X2 [Homo sapiens].
ACCESSION   XP_047288764
VERSION     XP_047288764.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432808.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1314
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1314
                     /product="Fanconi anemia group I protein isoform X2"
                     /calculated_mol_wt=147613
     Region          1..53
                     /region_name="FANCI_S1-cap"
                     /note="FANCI solenoid 1 cap; pfam14674"
                     /db_xref="CDD:434117"
     Region          43..1276
                     /region_name="FANCI"
                     /note="Fanconi anemia I protein; cd11720"
                     /db_xref="CDD:212594"
     Site            order(48,52,83..84,87,90..91,94..95,98,128,131,182..183,
                     215,219,273,277,280,376,442,446,449,480,483,486..487,490,
                     522..523,526,581..582,585..586,589..590,592..593,616,
                     618..622,625,628,678,689)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:212594"
     Site            order(287,291,294,331,336,339,966,1012,1064,1080,1093,
                     1150,1154,1164,1248,1255..1256)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212594"
     CDS             1..1314
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /coded_by="XM_047432808.1:193..4137"
                     /db_xref="GeneID:55215"
                     /db_xref="HGNC:HGNC:25568"
                     /db_xref="MIM:611360"
ORIGIN      
        1 mdqkilslaa ektadklqef lqtlregdlt nllqnqavkg kvagallrai fkgspcseea
       61 gtlrrrkiyt cciqlvesgd lqkeiaseii gllmleahhf pgpllvelan efisavregs
      121 lvngkslell piiltalatk kenlaygkgv lsgeeckkql intlcsgrwd qqyviqltsm
      181 fkdvpltaee vefvvekals mfskmnlqei pplvyqllvl sskgsrksvl egiiaffsal
      241 dkqhneeqsg delldvvtvp sgelrhvegt iilhivfaik ldyelgrelv khlkvgqqgd
      301 snnnlspfsi alllsvtriq rfqdqvldll ktsvvksfkd lqllqgskfl qnlvphrsyv
      361 stmilevvkn svhswdhvtq glvelgfilm dsygpkkvld gktietspsl srmpnqhack
      421 lganilletf kihemirqei leqvlnrvvt rasspishfl dllsnivmya plvlqscssk
      481 vteafdylsf lplqtvqrll kavqpllkvs msmrdclilv lrkamfanql darksavagf
      541 llllknfkvl gslsssqcsq slsvsqvhvd vhshynsvan etfcleimds lrrclsqqad
      601 vrlmlyegfy dvlrrnsqla nsvmqtllsq lkqfyepkpd llpplkleac iltqgdkisl
      661 qepldyllcc iqhclawykn tviplqqgee eeeeeeafye dlddilesit nrmikseled
      721 feldksadfs qstsigiknn icaflvmgvc evlieynfsi ssfsknrfed ilslfmcykk
      781 lsdilnekag kaktkmankt sdsllsmkfv sslltalfrs snefmryavn valqkvqqlk
      841 etghvsgpdg qnpekifqnl cditrvllwr ytsiptsvee sgkkekgksi sllcleglqk
      901 ifsavqqfyq pkiqqflral dvtdkegeer edadvsvtqr tafqirqfqr sllnllssqe
      961 edfnskeall lvtvltslsk llepsspqfv qmlswtskic kensredalf ckslmnllfs
     1021 lhvsykspvi llrdlsqdih ghlgdidqdv evektnhfai vnlrtaaptv cllvlsqaek
     1081 vleevdwlit klkgqvsqet lseeassqat lpnqpvekai imqlgtlltf fhelvqtalp
     1141 sgscvdtllk dlckmyttlt alvryylqvc qssggipknm eklvklsgsh ltplcysfis
     1201 yvqnksksln ytgekkekpa avatamarvl retkpipnli faieqyekfl ihlskkskvn
     1261 lmqhmklsts rdfkikgnil dmvlredged eneegtaseh ggqnkepakk krkk
//
LOCUS       XP_047288765            1314 aa            linear   PRI 05-AUG-2025
DEFINITION  Fanconi anemia group I protein isoform X2 [Homo sapiens].
ACCESSION   XP_047288765
VERSION     XP_047288765.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432809.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1314
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1314
                     /product="Fanconi anemia group I protein isoform X2"
                     /calculated_mol_wt=147613
     Region          1..53
                     /region_name="FANCI_S1-cap"
                     /note="FANCI solenoid 1 cap; pfam14674"
                     /db_xref="CDD:434117"
     Region          43..1276
                     /region_name="FANCI"
                     /note="Fanconi anemia I protein; cd11720"
                     /db_xref="CDD:212594"
     Site            order(48,52,83..84,87,90..91,94..95,98,128,131,182..183,
                     215,219,273,277,280,376,442,446,449,480,483,486..487,490,
                     522..523,526,581..582,585..586,589..590,592..593,616,
                     618..622,625,628,678,689)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:212594"
     Site            order(287,291,294,331,336,339,966,1012,1064,1080,1093,
                     1150,1154,1164,1248,1255..1256)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212594"
     CDS             1..1314
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /coded_by="XM_047432809.1:170..4114"
                     /db_xref="GeneID:55215"
                     /db_xref="HGNC:HGNC:25568"
                     /db_xref="MIM:611360"
ORIGIN      
        1 mdqkilslaa ektadklqef lqtlregdlt nllqnqavkg kvagallrai fkgspcseea
       61 gtlrrrkiyt cciqlvesgd lqkeiaseii gllmleahhf pgpllvelan efisavregs
      121 lvngkslell piiltalatk kenlaygkgv lsgeeckkql intlcsgrwd qqyviqltsm
      181 fkdvpltaee vefvvekals mfskmnlqei pplvyqllvl sskgsrksvl egiiaffsal
      241 dkqhneeqsg delldvvtvp sgelrhvegt iilhivfaik ldyelgrelv khlkvgqqgd
      301 snnnlspfsi alllsvtriq rfqdqvldll ktsvvksfkd lqllqgskfl qnlvphrsyv
      361 stmilevvkn svhswdhvtq glvelgfilm dsygpkkvld gktietspsl srmpnqhack
      421 lganilletf kihemirqei leqvlnrvvt rasspishfl dllsnivmya plvlqscssk
      481 vteafdylsf lplqtvqrll kavqpllkvs msmrdclilv lrkamfanql darksavagf
      541 llllknfkvl gslsssqcsq slsvsqvhvd vhshynsvan etfcleimds lrrclsqqad
      601 vrlmlyegfy dvlrrnsqla nsvmqtllsq lkqfyepkpd llpplkleac iltqgdkisl
      661 qepldyllcc iqhclawykn tviplqqgee eeeeeeafye dlddilesit nrmikseled
      721 feldksadfs qstsigiknn icaflvmgvc evlieynfsi ssfsknrfed ilslfmcykk
      781 lsdilnekag kaktkmankt sdsllsmkfv sslltalfrs snefmryavn valqkvqqlk
      841 etghvsgpdg qnpekifqnl cditrvllwr ytsiptsvee sgkkekgksi sllcleglqk
      901 ifsavqqfyq pkiqqflral dvtdkegeer edadvsvtqr tafqirqfqr sllnllssqe
      961 edfnskeall lvtvltslsk llepsspqfv qmlswtskic kensredalf ckslmnllfs
     1021 lhvsykspvi llrdlsqdih ghlgdidqdv evektnhfai vnlrtaaptv cllvlsqaek
     1081 vleevdwlit klkgqvsqet lseeassqat lpnqpvekai imqlgtlltf fhelvqtalp
     1141 sgscvdtllk dlckmyttlt alvryylqvc qssggipknm eklvklsgsh ltplcysfis
     1201 yvqnksksln ytgekkekpa avatamarvl retkpipnli faieqyekfl ihlskkskvn
     1261 lmqhmklsts rdfkikgnil dmvlredged eneegtaseh ggqnkepakk krkk
//
LOCUS       XP_047288766            1314 aa            linear   PRI 05-AUG-2025
DEFINITION  Fanconi anemia group I protein isoform X2 [Homo sapiens].
ACCESSION   XP_047288766
VERSION     XP_047288766.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432810.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1314
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1314
                     /product="Fanconi anemia group I protein isoform X2"
                     /calculated_mol_wt=147613
     Region          1..53
                     /region_name="FANCI_S1-cap"
                     /note="FANCI solenoid 1 cap; pfam14674"
                     /db_xref="CDD:434117"
     Region          43..1276
                     /region_name="FANCI"
                     /note="Fanconi anemia I protein; cd11720"
                     /db_xref="CDD:212594"
     Site            order(48,52,83..84,87,90..91,94..95,98,128,131,182..183,
                     215,219,273,277,280,376,442,446,449,480,483,486..487,490,
                     522..523,526,581..582,585..586,589..590,592..593,616,
                     618..622,625,628,678,689)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:212594"
     Site            order(287,291,294,331,336,339,966,1012,1064,1080,1093,
                     1150,1154,1164,1248,1255..1256)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212594"
     CDS             1..1314
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /coded_by="XM_047432810.1:177..4121"
                     /db_xref="GeneID:55215"
                     /db_xref="HGNC:HGNC:25568"
                     /db_xref="MIM:611360"
ORIGIN      
        1 mdqkilslaa ektadklqef lqtlregdlt nllqnqavkg kvagallrai fkgspcseea
       61 gtlrrrkiyt cciqlvesgd lqkeiaseii gllmleahhf pgpllvelan efisavregs
      121 lvngkslell piiltalatk kenlaygkgv lsgeeckkql intlcsgrwd qqyviqltsm
      181 fkdvpltaee vefvvekals mfskmnlqei pplvyqllvl sskgsrksvl egiiaffsal
      241 dkqhneeqsg delldvvtvp sgelrhvegt iilhivfaik ldyelgrelv khlkvgqqgd
      301 snnnlspfsi alllsvtriq rfqdqvldll ktsvvksfkd lqllqgskfl qnlvphrsyv
      361 stmilevvkn svhswdhvtq glvelgfilm dsygpkkvld gktietspsl srmpnqhack
      421 lganilletf kihemirqei leqvlnrvvt rasspishfl dllsnivmya plvlqscssk
      481 vteafdylsf lplqtvqrll kavqpllkvs msmrdclilv lrkamfanql darksavagf
      541 llllknfkvl gslsssqcsq slsvsqvhvd vhshynsvan etfcleimds lrrclsqqad
      601 vrlmlyegfy dvlrrnsqla nsvmqtllsq lkqfyepkpd llpplkleac iltqgdkisl
      661 qepldyllcc iqhclawykn tviplqqgee eeeeeeafye dlddilesit nrmikseled
      721 feldksadfs qstsigiknn icaflvmgvc evlieynfsi ssfsknrfed ilslfmcykk
      781 lsdilnekag kaktkmankt sdsllsmkfv sslltalfrs snefmryavn valqkvqqlk
      841 etghvsgpdg qnpekifqnl cditrvllwr ytsiptsvee sgkkekgksi sllcleglqk
      901 ifsavqqfyq pkiqqflral dvtdkegeer edadvsvtqr tafqirqfqr sllnllssqe
      961 edfnskeall lvtvltslsk llepsspqfv qmlswtskic kensredalf ckslmnllfs
     1021 lhvsykspvi llrdlsqdih ghlgdidqdv evektnhfai vnlrtaaptv cllvlsqaek
     1081 vleevdwlit klkgqvsqet lseeassqat lpnqpvekai imqlgtlltf fhelvqtalp
     1141 sgscvdtllk dlckmyttlt alvryylqvc qssggipknm eklvklsgsh ltplcysfis
     1201 yvqnksksln ytgekkekpa avatamarvl retkpipnli faieqyekfl ihlskkskvn
     1261 lmqhmklsts rdfkikgnil dmvlredged eneegtaseh ggqnkepakk krkk
//
LOCUS       XP_047288767            1314 aa            linear   PRI 05-AUG-2025
DEFINITION  Fanconi anemia group I protein isoform X2 [Homo sapiens].
ACCESSION   XP_047288767
VERSION     XP_047288767.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432811.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1314
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1314
                     /product="Fanconi anemia group I protein isoform X2"
                     /calculated_mol_wt=147613
     Region          1..53
                     /region_name="FANCI_S1-cap"
                     /note="FANCI solenoid 1 cap; pfam14674"
                     /db_xref="CDD:434117"
     Region          43..1276
                     /region_name="FANCI"
                     /note="Fanconi anemia I protein; cd11720"
                     /db_xref="CDD:212594"
     Site            order(48,52,83..84,87,90..91,94..95,98,128,131,182..183,
                     215,219,273,277,280,376,442,446,449,480,483,486..487,490,
                     522..523,526,581..582,585..586,589..590,592..593,616,
                     618..622,625,628,678,689)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:212594"
     Site            order(287,291,294,331,336,339,966,1012,1064,1080,1093,
                     1150,1154,1164,1248,1255..1256)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212594"
     CDS             1..1314
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /coded_by="XM_047432811.1:211..4155"
                     /db_xref="GeneID:55215"
                     /db_xref="HGNC:HGNC:25568"
                     /db_xref="MIM:611360"
ORIGIN      
        1 mdqkilslaa ektadklqef lqtlregdlt nllqnqavkg kvagallrai fkgspcseea
       61 gtlrrrkiyt cciqlvesgd lqkeiaseii gllmleahhf pgpllvelan efisavregs
      121 lvngkslell piiltalatk kenlaygkgv lsgeeckkql intlcsgrwd qqyviqltsm
      181 fkdvpltaee vefvvekals mfskmnlqei pplvyqllvl sskgsrksvl egiiaffsal
      241 dkqhneeqsg delldvvtvp sgelrhvegt iilhivfaik ldyelgrelv khlkvgqqgd
      301 snnnlspfsi alllsvtriq rfqdqvldll ktsvvksfkd lqllqgskfl qnlvphrsyv
      361 stmilevvkn svhswdhvtq glvelgfilm dsygpkkvld gktietspsl srmpnqhack
      421 lganilletf kihemirqei leqvlnrvvt rasspishfl dllsnivmya plvlqscssk
      481 vteafdylsf lplqtvqrll kavqpllkvs msmrdclilv lrkamfanql darksavagf
      541 llllknfkvl gslsssqcsq slsvsqvhvd vhshynsvan etfcleimds lrrclsqqad
      601 vrlmlyegfy dvlrrnsqla nsvmqtllsq lkqfyepkpd llpplkleac iltqgdkisl
      661 qepldyllcc iqhclawykn tviplqqgee eeeeeeafye dlddilesit nrmikseled
      721 feldksadfs qstsigiknn icaflvmgvc evlieynfsi ssfsknrfed ilslfmcykk
      781 lsdilnekag kaktkmankt sdsllsmkfv sslltalfrs snefmryavn valqkvqqlk
      841 etghvsgpdg qnpekifqnl cditrvllwr ytsiptsvee sgkkekgksi sllcleglqk
      901 ifsavqqfyq pkiqqflral dvtdkegeer edadvsvtqr tafqirqfqr sllnllssqe
      961 edfnskeall lvtvltslsk llepsspqfv qmlswtskic kensredalf ckslmnllfs
     1021 lhvsykspvi llrdlsqdih ghlgdidqdv evektnhfai vnlrtaaptv cllvlsqaek
     1081 vleevdwlit klkgqvsqet lseeassqat lpnqpvekai imqlgtlltf fhelvqtalp
     1141 sgscvdtllk dlckmyttlt alvryylqvc qssggipknm eklvklsgsh ltplcysfis
     1201 yvqnksksln ytgekkekpa avatamarvl retkpipnli faieqyekfl ihlskkskvn
     1261 lmqhmklsts rdfkikgnil dmvlredged eneegtaseh ggqnkepakk krkk
//
LOCUS       XP_047288768            1314 aa            linear   PRI 05-AUG-2025
DEFINITION  Fanconi anemia group I protein isoform X2 [Homo sapiens].
ACCESSION   XP_047288768
VERSION     XP_047288768.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432812.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1314
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1314
                     /product="Fanconi anemia group I protein isoform X2"
                     /calculated_mol_wt=147613
     Region          1..53
                     /region_name="FANCI_S1-cap"
                     /note="FANCI solenoid 1 cap; pfam14674"
                     /db_xref="CDD:434117"
     Region          43..1276
                     /region_name="FANCI"
                     /note="Fanconi anemia I protein; cd11720"
                     /db_xref="CDD:212594"
     Site            order(48,52,83..84,87,90..91,94..95,98,128,131,182..183,
                     215,219,273,277,280,376,442,446,449,480,483,486..487,490,
                     522..523,526,581..582,585..586,589..590,592..593,616,
                     618..622,625,628,678,689)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:212594"
     Site            order(287,291,294,331,336,339,966,1012,1064,1080,1093,
                     1150,1154,1164,1248,1255..1256)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212594"
     CDS             1..1314
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /coded_by="XM_047432812.1:188..4132"
                     /db_xref="GeneID:55215"
                     /db_xref="HGNC:HGNC:25568"
                     /db_xref="MIM:611360"
ORIGIN      
        1 mdqkilslaa ektadklqef lqtlregdlt nllqnqavkg kvagallrai fkgspcseea
       61 gtlrrrkiyt cciqlvesgd lqkeiaseii gllmleahhf pgpllvelan efisavregs
      121 lvngkslell piiltalatk kenlaygkgv lsgeeckkql intlcsgrwd qqyviqltsm
      181 fkdvpltaee vefvvekals mfskmnlqei pplvyqllvl sskgsrksvl egiiaffsal
      241 dkqhneeqsg delldvvtvp sgelrhvegt iilhivfaik ldyelgrelv khlkvgqqgd
      301 snnnlspfsi alllsvtriq rfqdqvldll ktsvvksfkd lqllqgskfl qnlvphrsyv
      361 stmilevvkn svhswdhvtq glvelgfilm dsygpkkvld gktietspsl srmpnqhack
      421 lganilletf kihemirqei leqvlnrvvt rasspishfl dllsnivmya plvlqscssk
      481 vteafdylsf lplqtvqrll kavqpllkvs msmrdclilv lrkamfanql darksavagf
      541 llllknfkvl gslsssqcsq slsvsqvhvd vhshynsvan etfcleimds lrrclsqqad
      601 vrlmlyegfy dvlrrnsqla nsvmqtllsq lkqfyepkpd llpplkleac iltqgdkisl
      661 qepldyllcc iqhclawykn tviplqqgee eeeeeeafye dlddilesit nrmikseled
      721 feldksadfs qstsigiknn icaflvmgvc evlieynfsi ssfsknrfed ilslfmcykk
      781 lsdilnekag kaktkmankt sdsllsmkfv sslltalfrs snefmryavn valqkvqqlk
      841 etghvsgpdg qnpekifqnl cditrvllwr ytsiptsvee sgkkekgksi sllcleglqk
      901 ifsavqqfyq pkiqqflral dvtdkegeer edadvsvtqr tafqirqfqr sllnllssqe
      961 edfnskeall lvtvltslsk llepsspqfv qmlswtskic kensredalf ckslmnllfs
     1021 lhvsykspvi llrdlsqdih ghlgdidqdv evektnhfai vnlrtaaptv cllvlsqaek
     1081 vleevdwlit klkgqvsqet lseeassqat lpnqpvekai imqlgtlltf fhelvqtalp
     1141 sgscvdtllk dlckmyttlt alvryylqvc qssggipknm eklvklsgsh ltplcysfis
     1201 yvqnksksln ytgekkekpa avatamarvl retkpipnli faieqyekfl ihlskkskvn
     1261 lmqhmklsts rdfkikgnil dmvlredged eneegtaseh ggqnkepakk krkk
//
LOCUS       XP_011520066            1268 aa            linear   PRI 05-AUG-2025
DEFINITION  Fanconi anemia group I protein isoform X3 [Homo sapiens].
ACCESSION   XP_011520066
VERSION     XP_011520066.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521764.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1268
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1268
                     /product="Fanconi anemia group I protein isoform X3"
                     /calculated_mol_wt=142439
     Region          1..53
                     /region_name="FANCI_S1-cap"
                     /note="FANCI solenoid 1 cap; pfam14674"
                     /db_xref="CDD:434117"
     Region          43..1230
                     /region_name="FANCI"
                     /note="Fanconi anemia I protein; cd11720"
                     /db_xref="CDD:212594"
     Site            order(48,52,83..84,87,90..91,94..95,98,128,131,182..183,
                     215,219,273,277,280,376,442,446,449,480,483,486..487,490,
                     522..523,526,581..582,585..586,589..590,592..593,616,
                     618..622,625,628,678,689)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:212594"
     Site            order(287,291,294,331,336,339,920,966,1018,1034,1047,1104,
                     1108,1118,1202,1209..1210)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212594"
     CDS             1..1268
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /coded_by="XM_011521764.3:109..3915"
                     /db_xref="GeneID:55215"
                     /db_xref="HGNC:HGNC:25568"
                     /db_xref="MIM:611360"
ORIGIN      
        1 mdqkilslaa ektadklqef lqtlregdlt nllqnqavkg kvagallrai fkgspcseea
       61 gtlrrrkiyt cciqlvesgd lqkeiaseii gllmleahhf pgpllvelan efisavregs
      121 lvngkslell piiltalatk kenlaygkgv lsgeeckkql intlcsgrwd qqyviqltsm
      181 fkdvpltaee vefvvekals mfskmnlqei pplvyqllvl sskgsrksvl egiiaffsal
      241 dkqhneeqsg delldvvtvp sgelrhvegt iilhivfaik ldyelgrelv khlkvgqqgd
      301 snnnlspfsi alllsvtriq rfqdqvldll ktsvvksfkd lqllqgskfl qnlvphrsyv
      361 stmilevvkn svhswdhvtq glvelgfilm dsygpkkvld gktietspsl srmpnqhack
      421 lganilletf kihemirqei leqvlnrvvt rasspishfl dllsnivmya plvlqscssk
      481 vteafdylsf lplqtvqrll kavqpllkvs msmrdclilv lrkamfanql darksavagf
      541 llllknfkvl gslsssqcsq slsvsqvhvd vhshynsvan etfcleimds lrrclsqqad
      601 vrlmlyegfy dvlrrnsqla nsvmqtllsq lkqfyepkpd llpplkleac iltqgdkisl
      661 qepldyllcc iqhclawykn tviplqqgee eeeeeeafye dlddilesit nrmikseled
      721 feldksadfs qstsigiknn icaflvmgvc evlieynfsi ssfsknrfed ilslfmcykk
      781 lsdilnekag kaktkmankt sdsllsmkfv sslltalfrv llwrytsipt sveesgkkek
      841 gksisllcle glqkifsavq qfyqpkiqqf lraldvtdke geeredadvs vtqrtafqir
      901 qfqrsllnll ssqeedfnsk ealllvtvlt slskllepss pqfvqmlswt skickensre
      961 dalfckslmn llfslhvsyk spvillrdls qdihghlgdi dqdvevektn hfaivnlrta
     1021 aptvcllvls qaekvleevd wlitklkgqv sqetlseeas sqatlpnqpv ekaiimqlgt
     1081 lltffhelvq talpsgscvd tllkdlckmy ttltalvryy lqvcqssggi pknmeklvkl
     1141 sgshltplcy sfisyvqnks kslnytgekk ekpaavatam arvlretkpi pnlifaieqy
     1201 ekflihlskk skvnlmqhmk lstsrdfkik gnildmvlre dgedeneegt asehggqnke
     1261 pakkkrkk
//
LOCUS       XP_047288769            1268 aa            linear   PRI 05-AUG-2025
DEFINITION  Fanconi anemia group I protein isoform X3 [Homo sapiens].
ACCESSION   XP_047288769
VERSION     XP_047288769.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432813.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1268
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1268
                     /product="Fanconi anemia group I protein isoform X3"
                     /calculated_mol_wt=142439
     Region          1..53
                     /region_name="FANCI_S1-cap"
                     /note="FANCI solenoid 1 cap; pfam14674"
                     /db_xref="CDD:434117"
     Region          43..1230
                     /region_name="FANCI"
                     /note="Fanconi anemia I protein; cd11720"
                     /db_xref="CDD:212594"
     Site            order(48,52,83..84,87,90..91,94..95,98,128,131,182..183,
                     215,219,273,277,280,376,442,446,449,480,483,486..487,490,
                     522..523,526,581..582,585..586,589..590,592..593,616,
                     618..622,625,628,678,689)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:212594"
     Site            order(287,291,294,331,336,339,920,966,1018,1034,1047,1104,
                     1108,1118,1202,1209..1210)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212594"
     CDS             1..1268
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /coded_by="XM_047432813.1:86..3892"
                     /db_xref="GeneID:55215"
                     /db_xref="HGNC:HGNC:25568"
                     /db_xref="MIM:611360"
ORIGIN      
        1 mdqkilslaa ektadklqef lqtlregdlt nllqnqavkg kvagallrai fkgspcseea
       61 gtlrrrkiyt cciqlvesgd lqkeiaseii gllmleahhf pgpllvelan efisavregs
      121 lvngkslell piiltalatk kenlaygkgv lsgeeckkql intlcsgrwd qqyviqltsm
      181 fkdvpltaee vefvvekals mfskmnlqei pplvyqllvl sskgsrksvl egiiaffsal
      241 dkqhneeqsg delldvvtvp sgelrhvegt iilhivfaik ldyelgrelv khlkvgqqgd
      301 snnnlspfsi alllsvtriq rfqdqvldll ktsvvksfkd lqllqgskfl qnlvphrsyv
      361 stmilevvkn svhswdhvtq glvelgfilm dsygpkkvld gktietspsl srmpnqhack
      421 lganilletf kihemirqei leqvlnrvvt rasspishfl dllsnivmya plvlqscssk
      481 vteafdylsf lplqtvqrll kavqpllkvs msmrdclilv lrkamfanql darksavagf
      541 llllknfkvl gslsssqcsq slsvsqvhvd vhshynsvan etfcleimds lrrclsqqad
      601 vrlmlyegfy dvlrrnsqla nsvmqtllsq lkqfyepkpd llpplkleac iltqgdkisl
      661 qepldyllcc iqhclawykn tviplqqgee eeeeeeafye dlddilesit nrmikseled
      721 feldksadfs qstsigiknn icaflvmgvc evlieynfsi ssfsknrfed ilslfmcykk
      781 lsdilnekag kaktkmankt sdsllsmkfv sslltalfrv llwrytsipt sveesgkkek
      841 gksisllcle glqkifsavq qfyqpkiqqf lraldvtdke geeredadvs vtqrtafqir
      901 qfqrsllnll ssqeedfnsk ealllvtvlt slskllepss pqfvqmlswt skickensre
      961 dalfckslmn llfslhvsyk spvillrdls qdihghlgdi dqdvevektn hfaivnlrta
     1021 aptvcllvls qaekvleevd wlitklkgqv sqetlseeas sqatlpnqpv ekaiimqlgt
     1081 lltffhelvq talpsgscvd tllkdlckmy ttltalvryy lqvcqssggi pknmeklvkl
     1141 sgshltplcy sfisyvqnks kslnytgekk ekpaavatam arvlretkpi pnlifaieqy
     1201 ekflihlskk skvnlmqhmk lstsrdfkik gnildmvlre dgedeneegt asehggqnke
     1261 pakkkrkk
//
LOCUS       XP_047288770            1268 aa            linear   PRI 05-AUG-2025
DEFINITION  Fanconi anemia group I protein isoform X3 [Homo sapiens].
ACCESSION   XP_047288770
VERSION     XP_047288770.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432814.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1268
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1268
                     /product="Fanconi anemia group I protein isoform X3"
                     /calculated_mol_wt=142439
     Region          1..53
                     /region_name="FANCI_S1-cap"
                     /note="FANCI solenoid 1 cap; pfam14674"
                     /db_xref="CDD:434117"
     Region          43..1230
                     /region_name="FANCI"
                     /note="Fanconi anemia I protein; cd11720"
                     /db_xref="CDD:212594"
     Site            order(48,52,83..84,87,90..91,94..95,98,128,131,182..183,
                     215,219,273,277,280,376,442,446,449,480,483,486..487,490,
                     522..523,526,581..582,585..586,589..590,592..593,616,
                     618..622,625,628,678,689)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:212594"
     Site            order(287,291,294,331,336,339,920,966,1018,1034,1047,1104,
                     1108,1118,1202,1209..1210)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212594"
     CDS             1..1268
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /coded_by="XM_047432814.1:211..4017"
                     /db_xref="GeneID:55215"
                     /db_xref="HGNC:HGNC:25568"
                     /db_xref="MIM:611360"
ORIGIN      
        1 mdqkilslaa ektadklqef lqtlregdlt nllqnqavkg kvagallrai fkgspcseea
       61 gtlrrrkiyt cciqlvesgd lqkeiaseii gllmleahhf pgpllvelan efisavregs
      121 lvngkslell piiltalatk kenlaygkgv lsgeeckkql intlcsgrwd qqyviqltsm
      181 fkdvpltaee vefvvekals mfskmnlqei pplvyqllvl sskgsrksvl egiiaffsal
      241 dkqhneeqsg delldvvtvp sgelrhvegt iilhivfaik ldyelgrelv khlkvgqqgd
      301 snnnlspfsi alllsvtriq rfqdqvldll ktsvvksfkd lqllqgskfl qnlvphrsyv
      361 stmilevvkn svhswdhvtq glvelgfilm dsygpkkvld gktietspsl srmpnqhack
      421 lganilletf kihemirqei leqvlnrvvt rasspishfl dllsnivmya plvlqscssk
      481 vteafdylsf lplqtvqrll kavqpllkvs msmrdclilv lrkamfanql darksavagf
      541 llllknfkvl gslsssqcsq slsvsqvhvd vhshynsvan etfcleimds lrrclsqqad
      601 vrlmlyegfy dvlrrnsqla nsvmqtllsq lkqfyepkpd llpplkleac iltqgdkisl
      661 qepldyllcc iqhclawykn tviplqqgee eeeeeeafye dlddilesit nrmikseled
      721 feldksadfs qstsigiknn icaflvmgvc evlieynfsi ssfsknrfed ilslfmcykk
      781 lsdilnekag kaktkmankt sdsllsmkfv sslltalfrv llwrytsipt sveesgkkek
      841 gksisllcle glqkifsavq qfyqpkiqqf lraldvtdke geeredadvs vtqrtafqir
      901 qfqrsllnll ssqeedfnsk ealllvtvlt slskllepss pqfvqmlswt skickensre
      961 dalfckslmn llfslhvsyk spvillrdls qdihghlgdi dqdvevektn hfaivnlrta
     1021 aptvcllvls qaekvleevd wlitklkgqv sqetlseeas sqatlpnqpv ekaiimqlgt
     1081 lltffhelvq talpsgscvd tllkdlckmy ttltalvryy lqvcqssggi pknmeklvkl
     1141 sgshltplcy sfisyvqnks kslnytgekk ekpaavatam arvlretkpi pnlifaieqy
     1201 ekflihlskk skvnlmqhmk lstsrdfkik gnildmvlre dgedeneegt asehggqnke
     1261 pakkkrkk
//
LOCUS       XP_047288771            1268 aa            linear   PRI 05-AUG-2025
DEFINITION  Fanconi anemia group I protein isoform X3 [Homo sapiens].
ACCESSION   XP_047288771
VERSION     XP_047288771.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432815.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1268
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1268
                     /product="Fanconi anemia group I protein isoform X3"
                     /calculated_mol_wt=142439
     Region          1..53
                     /region_name="FANCI_S1-cap"
                     /note="FANCI solenoid 1 cap; pfam14674"
                     /db_xref="CDD:434117"
     Region          43..1230
                     /region_name="FANCI"
                     /note="Fanconi anemia I protein; cd11720"
                     /db_xref="CDD:212594"
     Site            order(48,52,83..84,87,90..91,94..95,98,128,131,182..183,
                     215,219,273,277,280,376,442,446,449,480,483,486..487,490,
                     522..523,526,581..582,585..586,589..590,592..593,616,
                     618..622,625,628,678,689)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:212594"
     Site            order(287,291,294,331,336,339,920,966,1018,1034,1047,1104,
                     1108,1118,1202,1209..1210)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212594"
     CDS             1..1268
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /coded_by="XM_047432815.1:1353..5159"
                     /db_xref="GeneID:55215"
                     /db_xref="HGNC:HGNC:25568"
                     /db_xref="MIM:611360"
ORIGIN      
        1 mdqkilslaa ektadklqef lqtlregdlt nllqnqavkg kvagallrai fkgspcseea
       61 gtlrrrkiyt cciqlvesgd lqkeiaseii gllmleahhf pgpllvelan efisavregs
      121 lvngkslell piiltalatk kenlaygkgv lsgeeckkql intlcsgrwd qqyviqltsm
      181 fkdvpltaee vefvvekals mfskmnlqei pplvyqllvl sskgsrksvl egiiaffsal
      241 dkqhneeqsg delldvvtvp sgelrhvegt iilhivfaik ldyelgrelv khlkvgqqgd
      301 snnnlspfsi alllsvtriq rfqdqvldll ktsvvksfkd lqllqgskfl qnlvphrsyv
      361 stmilevvkn svhswdhvtq glvelgfilm dsygpkkvld gktietspsl srmpnqhack
      421 lganilletf kihemirqei leqvlnrvvt rasspishfl dllsnivmya plvlqscssk
      481 vteafdylsf lplqtvqrll kavqpllkvs msmrdclilv lrkamfanql darksavagf
      541 llllknfkvl gslsssqcsq slsvsqvhvd vhshynsvan etfcleimds lrrclsqqad
      601 vrlmlyegfy dvlrrnsqla nsvmqtllsq lkqfyepkpd llpplkleac iltqgdkisl
      661 qepldyllcc iqhclawykn tviplqqgee eeeeeeafye dlddilesit nrmikseled
      721 feldksadfs qstsigiknn icaflvmgvc evlieynfsi ssfsknrfed ilslfmcykk
      781 lsdilnekag kaktkmankt sdsllsmkfv sslltalfrv llwrytsipt sveesgkkek
      841 gksisllcle glqkifsavq qfyqpkiqqf lraldvtdke geeredadvs vtqrtafqir
      901 qfqrsllnll ssqeedfnsk ealllvtvlt slskllepss pqfvqmlswt skickensre
      961 dalfckslmn llfslhvsyk spvillrdls qdihghlgdi dqdvevektn hfaivnlrta
     1021 aptvcllvls qaekvleevd wlitklkgqv sqetlseeas sqatlpnqpv ekaiimqlgt
     1081 lltffhelvq talpsgscvd tllkdlckmy ttltalvryy lqvcqssggi pknmeklvkl
     1141 sgshltplcy sfisyvqnks kslnytgekk ekpaavatam arvlretkpi pnlifaieqy
     1201 ekflihlskk skvnlmqhmk lstsrdfkik gnildmvlre dgedeneegt asehggqnke
     1261 pakkkrkk
//
LOCUS       XP_047288772            1268 aa            linear   PRI 05-AUG-2025
DEFINITION  Fanconi anemia group I protein isoform X3 [Homo sapiens].
ACCESSION   XP_047288772
VERSION     XP_047288772.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432816.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1268
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1268
                     /product="Fanconi anemia group I protein isoform X3"
                     /calculated_mol_wt=142439
     Region          1..53
                     /region_name="FANCI_S1-cap"
                     /note="FANCI solenoid 1 cap; pfam14674"
                     /db_xref="CDD:434117"
     Region          43..1230
                     /region_name="FANCI"
                     /note="Fanconi anemia I protein; cd11720"
                     /db_xref="CDD:212594"
     Site            order(48,52,83..84,87,90..91,94..95,98,128,131,182..183,
                     215,219,273,277,280,376,442,446,449,480,483,486..487,490,
                     522..523,526,581..582,585..586,589..590,592..593,616,
                     618..622,625,628,678,689)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:212594"
     Site            order(287,291,294,331,336,339,920,966,1018,1034,1047,1104,
                     1108,1118,1202,1209..1210)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212594"
     CDS             1..1268
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /coded_by="XM_047432816.1:193..3999"
                     /db_xref="GeneID:55215"
                     /db_xref="HGNC:HGNC:25568"
                     /db_xref="MIM:611360"
ORIGIN      
        1 mdqkilslaa ektadklqef lqtlregdlt nllqnqavkg kvagallrai fkgspcseea
       61 gtlrrrkiyt cciqlvesgd lqkeiaseii gllmleahhf pgpllvelan efisavregs
      121 lvngkslell piiltalatk kenlaygkgv lsgeeckkql intlcsgrwd qqyviqltsm
      181 fkdvpltaee vefvvekals mfskmnlqei pplvyqllvl sskgsrksvl egiiaffsal
      241 dkqhneeqsg delldvvtvp sgelrhvegt iilhivfaik ldyelgrelv khlkvgqqgd
      301 snnnlspfsi alllsvtriq rfqdqvldll ktsvvksfkd lqllqgskfl qnlvphrsyv
      361 stmilevvkn svhswdhvtq glvelgfilm dsygpkkvld gktietspsl srmpnqhack
      421 lganilletf kihemirqei leqvlnrvvt rasspishfl dllsnivmya plvlqscssk
      481 vteafdylsf lplqtvqrll kavqpllkvs msmrdclilv lrkamfanql darksavagf
      541 llllknfkvl gslsssqcsq slsvsqvhvd vhshynsvan etfcleimds lrrclsqqad
      601 vrlmlyegfy dvlrrnsqla nsvmqtllsq lkqfyepkpd llpplkleac iltqgdkisl
      661 qepldyllcc iqhclawykn tviplqqgee eeeeeeafye dlddilesit nrmikseled
      721 feldksadfs qstsigiknn icaflvmgvc evlieynfsi ssfsknrfed ilslfmcykk
      781 lsdilnekag kaktkmankt sdsllsmkfv sslltalfrv llwrytsipt sveesgkkek
      841 gksisllcle glqkifsavq qfyqpkiqqf lraldvtdke geeredadvs vtqrtafqir
      901 qfqrsllnll ssqeedfnsk ealllvtvlt slskllepss pqfvqmlswt skickensre
      961 dalfckslmn llfslhvsyk spvillrdls qdihghlgdi dqdvevektn hfaivnlrta
     1021 aptvcllvls qaekvleevd wlitklkgqv sqetlseeas sqatlpnqpv ekaiimqlgt
     1081 lltffhelvq talpsgscvd tllkdlckmy ttltalvryy lqvcqssggi pknmeklvkl
     1141 sgshltplcy sfisyvqnks kslnytgekk ekpaavatam arvlretkpi pnlifaieqy
     1201 ekflihlskk skvnlmqhmk lstsrdfkik gnildmvlre dgedeneegt asehggqnke
     1261 pakkkrkk
//
LOCUS       XP_047288773            1268 aa            linear   PRI 05-AUG-2025
DEFINITION  Fanconi anemia group I protein isoform X3 [Homo sapiens].
ACCESSION   XP_047288773
VERSION     XP_047288773.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432817.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1268
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1268
                     /product="Fanconi anemia group I protein isoform X3"
                     /calculated_mol_wt=142439
     Region          1..53
                     /region_name="FANCI_S1-cap"
                     /note="FANCI solenoid 1 cap; pfam14674"
                     /db_xref="CDD:434117"
     Region          43..1230
                     /region_name="FANCI"
                     /note="Fanconi anemia I protein; cd11720"
                     /db_xref="CDD:212594"
     Site            order(48,52,83..84,87,90..91,94..95,98,128,131,182..183,
                     215,219,273,277,280,376,442,446,449,480,483,486..487,490,
                     522..523,526,581..582,585..586,589..590,592..593,616,
                     618..622,625,628,678,689)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:212594"
     Site            order(287,291,294,331,336,339,920,966,1018,1034,1047,1104,
                     1108,1118,1202,1209..1210)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212594"
     CDS             1..1268
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /coded_by="XM_047432817.1:159..3965"
                     /db_xref="GeneID:55215"
                     /db_xref="HGNC:HGNC:25568"
                     /db_xref="MIM:611360"
ORIGIN      
        1 mdqkilslaa ektadklqef lqtlregdlt nllqnqavkg kvagallrai fkgspcseea
       61 gtlrrrkiyt cciqlvesgd lqkeiaseii gllmleahhf pgpllvelan efisavregs
      121 lvngkslell piiltalatk kenlaygkgv lsgeeckkql intlcsgrwd qqyviqltsm
      181 fkdvpltaee vefvvekals mfskmnlqei pplvyqllvl sskgsrksvl egiiaffsal
      241 dkqhneeqsg delldvvtvp sgelrhvegt iilhivfaik ldyelgrelv khlkvgqqgd
      301 snnnlspfsi alllsvtriq rfqdqvldll ktsvvksfkd lqllqgskfl qnlvphrsyv
      361 stmilevvkn svhswdhvtq glvelgfilm dsygpkkvld gktietspsl srmpnqhack
      421 lganilletf kihemirqei leqvlnrvvt rasspishfl dllsnivmya plvlqscssk
      481 vteafdylsf lplqtvqrll kavqpllkvs msmrdclilv lrkamfanql darksavagf
      541 llllknfkvl gslsssqcsq slsvsqvhvd vhshynsvan etfcleimds lrrclsqqad
      601 vrlmlyegfy dvlrrnsqla nsvmqtllsq lkqfyepkpd llpplkleac iltqgdkisl
      661 qepldyllcc iqhclawykn tviplqqgee eeeeeeafye dlddilesit nrmikseled
      721 feldksadfs qstsigiknn icaflvmgvc evlieynfsi ssfsknrfed ilslfmcykk
      781 lsdilnekag kaktkmankt sdsllsmkfv sslltalfrv llwrytsipt sveesgkkek
      841 gksisllcle glqkifsavq qfyqpkiqqf lraldvtdke geeredadvs vtqrtafqir
      901 qfqrsllnll ssqeedfnsk ealllvtvlt slskllepss pqfvqmlswt skickensre
      961 dalfckslmn llfslhvsyk spvillrdls qdihghlgdi dqdvevektn hfaivnlrta
     1021 aptvcllvls qaekvleevd wlitklkgqv sqetlseeas sqatlpnqpv ekaiimqlgt
     1081 lltffhelvq talpsgscvd tllkdlckmy ttltalvryy lqvcqssggi pknmeklvkl
     1141 sgshltplcy sfisyvqnks kslnytgekk ekpaavatam arvlretkpi pnlifaieqy
     1201 ekflihlskk skvnlmqhmk lstsrdfkik gnildmvlre dgedeneegt asehggqnke
     1261 pakkkrkk
//
LOCUS       XP_047288774            1268 aa            linear   PRI 05-AUG-2025
DEFINITION  Fanconi anemia group I protein isoform X3 [Homo sapiens].
ACCESSION   XP_047288774
VERSION     XP_047288774.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432818.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1268
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1268
                     /product="Fanconi anemia group I protein isoform X3"
                     /calculated_mol_wt=142439
     Region          1..53
                     /region_name="FANCI_S1-cap"
                     /note="FANCI solenoid 1 cap; pfam14674"
                     /db_xref="CDD:434117"
     Region          43..1230
                     /region_name="FANCI"
                     /note="Fanconi anemia I protein; cd11720"
                     /db_xref="CDD:212594"
     Site            order(48,52,83..84,87,90..91,94..95,98,128,131,182..183,
                     215,219,273,277,280,376,442,446,449,480,483,486..487,490,
                     522..523,526,581..582,585..586,589..590,592..593,616,
                     618..622,625,628,678,689)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:212594"
     Site            order(287,291,294,331,336,339,920,966,1018,1034,1047,1104,
                     1108,1118,1202,1209..1210)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212594"
     CDS             1..1268
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /coded_by="XM_047432818.1:188..3994"
                     /db_xref="GeneID:55215"
                     /db_xref="HGNC:HGNC:25568"
                     /db_xref="MIM:611360"
ORIGIN      
        1 mdqkilslaa ektadklqef lqtlregdlt nllqnqavkg kvagallrai fkgspcseea
       61 gtlrrrkiyt cciqlvesgd lqkeiaseii gllmleahhf pgpllvelan efisavregs
      121 lvngkslell piiltalatk kenlaygkgv lsgeeckkql intlcsgrwd qqyviqltsm
      181 fkdvpltaee vefvvekals mfskmnlqei pplvyqllvl sskgsrksvl egiiaffsal
      241 dkqhneeqsg delldvvtvp sgelrhvegt iilhivfaik ldyelgrelv khlkvgqqgd
      301 snnnlspfsi alllsvtriq rfqdqvldll ktsvvksfkd lqllqgskfl qnlvphrsyv
      361 stmilevvkn svhswdhvtq glvelgfilm dsygpkkvld gktietspsl srmpnqhack
      421 lganilletf kihemirqei leqvlnrvvt rasspishfl dllsnivmya plvlqscssk
      481 vteafdylsf lplqtvqrll kavqpllkvs msmrdclilv lrkamfanql darksavagf
      541 llllknfkvl gslsssqcsq slsvsqvhvd vhshynsvan etfcleimds lrrclsqqad
      601 vrlmlyegfy dvlrrnsqla nsvmqtllsq lkqfyepkpd llpplkleac iltqgdkisl
      661 qepldyllcc iqhclawykn tviplqqgee eeeeeeafye dlddilesit nrmikseled
      721 feldksadfs qstsigiknn icaflvmgvc evlieynfsi ssfsknrfed ilslfmcykk
      781 lsdilnekag kaktkmankt sdsllsmkfv sslltalfrv llwrytsipt sveesgkkek
      841 gksisllcle glqkifsavq qfyqpkiqqf lraldvtdke geeredadvs vtqrtafqir
      901 qfqrsllnll ssqeedfnsk ealllvtvlt slskllepss pqfvqmlswt skickensre
      961 dalfckslmn llfslhvsyk spvillrdls qdihghlgdi dqdvevektn hfaivnlrta
     1021 aptvcllvls qaekvleevd wlitklkgqv sqetlseeas sqatlpnqpv ekaiimqlgt
     1081 lltffhelvq talpsgscvd tllkdlckmy ttltalvryy lqvcqssggi pknmeklvkl
     1141 sgshltplcy sfisyvqnks kslnytgekk ekpaavatam arvlretkpi pnlifaieqy
     1201 ekflihlskk skvnlmqhmk lstsrdfkik gnildmvlre dgedeneegt asehggqnke
     1261 pakkkrkk
//
LOCUS       XP_047288775            1268 aa            linear   PRI 05-AUG-2025
DEFINITION  Fanconi anemia group I protein isoform X3 [Homo sapiens].
ACCESSION   XP_047288775
VERSION     XP_047288775.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432819.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1268
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1268
                     /product="Fanconi anemia group I protein isoform X3"
                     /calculated_mol_wt=142439
     Region          1..53
                     /region_name="FANCI_S1-cap"
                     /note="FANCI solenoid 1 cap; pfam14674"
                     /db_xref="CDD:434117"
     Region          43..1230
                     /region_name="FANCI"
                     /note="Fanconi anemia I protein; cd11720"
                     /db_xref="CDD:212594"
     Site            order(48,52,83..84,87,90..91,94..95,98,128,131,182..183,
                     215,219,273,277,280,376,442,446,449,480,483,486..487,490,
                     522..523,526,581..582,585..586,589..590,592..593,616,
                     618..622,625,628,678,689)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:212594"
     Site            order(287,291,294,331,336,339,920,966,1018,1034,1047,1104,
                     1108,1118,1202,1209..1210)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212594"
     CDS             1..1268
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /coded_by="XM_047432819.1:322..4128"
                     /db_xref="GeneID:55215"
                     /db_xref="HGNC:HGNC:25568"
                     /db_xref="MIM:611360"
ORIGIN      
        1 mdqkilslaa ektadklqef lqtlregdlt nllqnqavkg kvagallrai fkgspcseea
       61 gtlrrrkiyt cciqlvesgd lqkeiaseii gllmleahhf pgpllvelan efisavregs
      121 lvngkslell piiltalatk kenlaygkgv lsgeeckkql intlcsgrwd qqyviqltsm
      181 fkdvpltaee vefvvekals mfskmnlqei pplvyqllvl sskgsrksvl egiiaffsal
      241 dkqhneeqsg delldvvtvp sgelrhvegt iilhivfaik ldyelgrelv khlkvgqqgd
      301 snnnlspfsi alllsvtriq rfqdqvldll ktsvvksfkd lqllqgskfl qnlvphrsyv
      361 stmilevvkn svhswdhvtq glvelgfilm dsygpkkvld gktietspsl srmpnqhack
      421 lganilletf kihemirqei leqvlnrvvt rasspishfl dllsnivmya plvlqscssk
      481 vteafdylsf lplqtvqrll kavqpllkvs msmrdclilv lrkamfanql darksavagf
      541 llllknfkvl gslsssqcsq slsvsqvhvd vhshynsvan etfcleimds lrrclsqqad
      601 vrlmlyegfy dvlrrnsqla nsvmqtllsq lkqfyepkpd llpplkleac iltqgdkisl
      661 qepldyllcc iqhclawykn tviplqqgee eeeeeeafye dlddilesit nrmikseled
      721 feldksadfs qstsigiknn icaflvmgvc evlieynfsi ssfsknrfed ilslfmcykk
      781 lsdilnekag kaktkmankt sdsllsmkfv sslltalfrv llwrytsipt sveesgkkek
      841 gksisllcle glqkifsavq qfyqpkiqqf lraldvtdke geeredadvs vtqrtafqir
      901 qfqrsllnll ssqeedfnsk ealllvtvlt slskllepss pqfvqmlswt skickensre
      961 dalfckslmn llfslhvsyk spvillrdls qdihghlgdi dqdvevektn hfaivnlrta
     1021 aptvcllvls qaekvleevd wlitklkgqv sqetlseeas sqatlpnqpv ekaiimqlgt
     1081 lltffhelvq talpsgscvd tllkdlckmy ttltalvryy lqvcqssggi pknmeklvkl
     1141 sgshltplcy sfisyvqnks kslnytgekk ekpaavatam arvlretkpi pnlifaieqy
     1201 ekflihlskk skvnlmqhmk lstsrdfkik gnildmvlre dgedeneegt asehggqnke
     1261 pakkkrkk
//
LOCUS       XP_047288776            1268 aa            linear   PRI 05-AUG-2025
DEFINITION  Fanconi anemia group I protein isoform X3 [Homo sapiens].
ACCESSION   XP_047288776
VERSION     XP_047288776.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432820.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1268
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1268
                     /product="Fanconi anemia group I protein isoform X3"
                     /calculated_mol_wt=142439
     Region          1..53
                     /region_name="FANCI_S1-cap"
                     /note="FANCI solenoid 1 cap; pfam14674"
                     /db_xref="CDD:434117"
     Region          43..1230
                     /region_name="FANCI"
                     /note="Fanconi anemia I protein; cd11720"
                     /db_xref="CDD:212594"
     Site            order(48,52,83..84,87,90..91,94..95,98,128,131,182..183,
                     215,219,273,277,280,376,442,446,449,480,483,486..487,490,
                     522..523,526,581..582,585..586,589..590,592..593,616,
                     618..622,625,628,678,689)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:212594"
     Site            order(287,291,294,331,336,339,920,966,1018,1034,1047,1104,
                     1108,1118,1202,1209..1210)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212594"
     CDS             1..1268
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /coded_by="XM_047432820.1:177..3983"
                     /db_xref="GeneID:55215"
                     /db_xref="HGNC:HGNC:25568"
                     /db_xref="MIM:611360"
ORIGIN      
        1 mdqkilslaa ektadklqef lqtlregdlt nllqnqavkg kvagallrai fkgspcseea
       61 gtlrrrkiyt cciqlvesgd lqkeiaseii gllmleahhf pgpllvelan efisavregs
      121 lvngkslell piiltalatk kenlaygkgv lsgeeckkql intlcsgrwd qqyviqltsm
      181 fkdvpltaee vefvvekals mfskmnlqei pplvyqllvl sskgsrksvl egiiaffsal
      241 dkqhneeqsg delldvvtvp sgelrhvegt iilhivfaik ldyelgrelv khlkvgqqgd
      301 snnnlspfsi alllsvtriq rfqdqvldll ktsvvksfkd lqllqgskfl qnlvphrsyv
      361 stmilevvkn svhswdhvtq glvelgfilm dsygpkkvld gktietspsl srmpnqhack
      421 lganilletf kihemirqei leqvlnrvvt rasspishfl dllsnivmya plvlqscssk
      481 vteafdylsf lplqtvqrll kavqpllkvs msmrdclilv lrkamfanql darksavagf
      541 llllknfkvl gslsssqcsq slsvsqvhvd vhshynsvan etfcleimds lrrclsqqad
      601 vrlmlyegfy dvlrrnsqla nsvmqtllsq lkqfyepkpd llpplkleac iltqgdkisl
      661 qepldyllcc iqhclawykn tviplqqgee eeeeeeafye dlddilesit nrmikseled
      721 feldksadfs qstsigiknn icaflvmgvc evlieynfsi ssfsknrfed ilslfmcykk
      781 lsdilnekag kaktkmankt sdsllsmkfv sslltalfrv llwrytsipt sveesgkkek
      841 gksisllcle glqkifsavq qfyqpkiqqf lraldvtdke geeredadvs vtqrtafqir
      901 qfqrsllnll ssqeedfnsk ealllvtvlt slskllepss pqfvqmlswt skickensre
      961 dalfckslmn llfslhvsyk spvillrdls qdihghlgdi dqdvevektn hfaivnlrta
     1021 aptvcllvls qaekvleevd wlitklkgqv sqetlseeas sqatlpnqpv ekaiimqlgt
     1081 lltffhelvq talpsgscvd tllkdlckmy ttltalvryy lqvcqssggi pknmeklvkl
     1141 sgshltplcy sfisyvqnks kslnytgekk ekpaavatam arvlretkpi pnlifaieqy
     1201 ekflihlskk skvnlmqhmk lstsrdfkik gnildmvlre dgedeneegt asehggqnke
     1261 pakkkrkk
//
LOCUS       XP_047288777            1268 aa            linear   PRI 05-AUG-2025
DEFINITION  Fanconi anemia group I protein isoform X3 [Homo sapiens].
ACCESSION   XP_047288777
VERSION     XP_047288777.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432821.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1268
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1268
                     /product="Fanconi anemia group I protein isoform X3"
                     /calculated_mol_wt=142439
     Region          1..53
                     /region_name="FANCI_S1-cap"
                     /note="FANCI solenoid 1 cap; pfam14674"
                     /db_xref="CDD:434117"
     Region          43..1230
                     /region_name="FANCI"
                     /note="Fanconi anemia I protein; cd11720"
                     /db_xref="CDD:212594"
     Site            order(48,52,83..84,87,90..91,94..95,98,128,131,182..183,
                     215,219,273,277,280,376,442,446,449,480,483,486..487,490,
                     522..523,526,581..582,585..586,589..590,592..593,616,
                     618..622,625,628,678,689)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:212594"
     Site            order(287,291,294,331,336,339,920,966,1018,1034,1047,1104,
                     1108,1118,1202,1209..1210)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212594"
     CDS             1..1268
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /coded_by="XM_047432821.1:1891..5697"
                     /db_xref="GeneID:55215"
                     /db_xref="HGNC:HGNC:25568"
                     /db_xref="MIM:611360"
ORIGIN      
        1 mdqkilslaa ektadklqef lqtlregdlt nllqnqavkg kvagallrai fkgspcseea
       61 gtlrrrkiyt cciqlvesgd lqkeiaseii gllmleahhf pgpllvelan efisavregs
      121 lvngkslell piiltalatk kenlaygkgv lsgeeckkql intlcsgrwd qqyviqltsm
      181 fkdvpltaee vefvvekals mfskmnlqei pplvyqllvl sskgsrksvl egiiaffsal
      241 dkqhneeqsg delldvvtvp sgelrhvegt iilhivfaik ldyelgrelv khlkvgqqgd
      301 snnnlspfsi alllsvtriq rfqdqvldll ktsvvksfkd lqllqgskfl qnlvphrsyv
      361 stmilevvkn svhswdhvtq glvelgfilm dsygpkkvld gktietspsl srmpnqhack
      421 lganilletf kihemirqei leqvlnrvvt rasspishfl dllsnivmya plvlqscssk
      481 vteafdylsf lplqtvqrll kavqpllkvs msmrdclilv lrkamfanql darksavagf
      541 llllknfkvl gslsssqcsq slsvsqvhvd vhshynsvan etfcleimds lrrclsqqad
      601 vrlmlyegfy dvlrrnsqla nsvmqtllsq lkqfyepkpd llpplkleac iltqgdkisl
      661 qepldyllcc iqhclawykn tviplqqgee eeeeeeafye dlddilesit nrmikseled
      721 feldksadfs qstsigiknn icaflvmgvc evlieynfsi ssfsknrfed ilslfmcykk
      781 lsdilnekag kaktkmankt sdsllsmkfv sslltalfrv llwrytsipt sveesgkkek
      841 gksisllcle glqkifsavq qfyqpkiqqf lraldvtdke geeredadvs vtqrtafqir
      901 qfqrsllnll ssqeedfnsk ealllvtvlt slskllepss pqfvqmlswt skickensre
      961 dalfckslmn llfslhvsyk spvillrdls qdihghlgdi dqdvevektn hfaivnlrta
     1021 aptvcllvls qaekvleevd wlitklkgqv sqetlseeas sqatlpnqpv ekaiimqlgt
     1081 lltffhelvq talpsgscvd tllkdlckmy ttltalvryy lqvcqssggi pknmeklvkl
     1141 sgshltplcy sfisyvqnks kslnytgekk ekpaavatam arvlretkpi pnlifaieqy
     1201 ekflihlskk skvnlmqhmk lstsrdfkik gnildmvlre dgedeneegt asehggqnke
     1261 pakkkrkk
//
LOCUS       XP_047288778            1268 aa            linear   PRI 05-AUG-2025
DEFINITION  Fanconi anemia group I protein isoform X3 [Homo sapiens].
ACCESSION   XP_047288778
VERSION     XP_047288778.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432822.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1268
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1268
                     /product="Fanconi anemia group I protein isoform X3"
                     /calculated_mol_wt=142439
     Region          1..53
                     /region_name="FANCI_S1-cap"
                     /note="FANCI solenoid 1 cap; pfam14674"
                     /db_xref="CDD:434117"
     Region          43..1230
                     /region_name="FANCI"
                     /note="Fanconi anemia I protein; cd11720"
                     /db_xref="CDD:212594"
     Site            order(48,52,83..84,87,90..91,94..95,98,128,131,182..183,
                     215,219,273,277,280,376,442,446,449,480,483,486..487,490,
                     522..523,526,581..582,585..586,589..590,592..593,616,
                     618..622,625,628,678,689)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:212594"
     Site            order(287,291,294,331,336,339,920,966,1018,1034,1047,1104,
                     1108,1118,1202,1209..1210)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212594"
     CDS             1..1268
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /coded_by="XM_047432822.1:170..3976"
                     /db_xref="GeneID:55215"
                     /db_xref="HGNC:HGNC:25568"
                     /db_xref="MIM:611360"
ORIGIN      
        1 mdqkilslaa ektadklqef lqtlregdlt nllqnqavkg kvagallrai fkgspcseea
       61 gtlrrrkiyt cciqlvesgd lqkeiaseii gllmleahhf pgpllvelan efisavregs
      121 lvngkslell piiltalatk kenlaygkgv lsgeeckkql intlcsgrwd qqyviqltsm
      181 fkdvpltaee vefvvekals mfskmnlqei pplvyqllvl sskgsrksvl egiiaffsal
      241 dkqhneeqsg delldvvtvp sgelrhvegt iilhivfaik ldyelgrelv khlkvgqqgd
      301 snnnlspfsi alllsvtriq rfqdqvldll ktsvvksfkd lqllqgskfl qnlvphrsyv
      361 stmilevvkn svhswdhvtq glvelgfilm dsygpkkvld gktietspsl srmpnqhack
      421 lganilletf kihemirqei leqvlnrvvt rasspishfl dllsnivmya plvlqscssk
      481 vteafdylsf lplqtvqrll kavqpllkvs msmrdclilv lrkamfanql darksavagf
      541 llllknfkvl gslsssqcsq slsvsqvhvd vhshynsvan etfcleimds lrrclsqqad
      601 vrlmlyegfy dvlrrnsqla nsvmqtllsq lkqfyepkpd llpplkleac iltqgdkisl
      661 qepldyllcc iqhclawykn tviplqqgee eeeeeeafye dlddilesit nrmikseled
      721 feldksadfs qstsigiknn icaflvmgvc evlieynfsi ssfsknrfed ilslfmcykk
      781 lsdilnekag kaktkmankt sdsllsmkfv sslltalfrv llwrytsipt sveesgkkek
      841 gksisllcle glqkifsavq qfyqpkiqqf lraldvtdke geeredadvs vtqrtafqir
      901 qfqrsllnll ssqeedfnsk ealllvtvlt slskllepss pqfvqmlswt skickensre
      961 dalfckslmn llfslhvsyk spvillrdls qdihghlgdi dqdvevektn hfaivnlrta
     1021 aptvcllvls qaekvleevd wlitklkgqv sqetlseeas sqatlpnqpv ekaiimqlgt
     1081 lltffhelvq talpsgscvd tllkdlckmy ttltalvryy lqvcqssggi pknmeklvkl
     1141 sgshltplcy sfisyvqnks kslnytgekk ekpaavatam arvlretkpi pnlifaieqy
     1201 ekflihlskk skvnlmqhmk lstsrdfkik gnildmvlre dgedeneegt asehggqnke
     1261 pakkkrkk
//
LOCUS       XP_047288779            1213 aa            linear   PRI 05-AUG-2025
DEFINITION  Fanconi anemia group I protein isoform X4 [Homo sapiens].
ACCESSION   XP_047288779
VERSION     XP_047288779.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432823.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1213
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1213
                     /product="Fanconi anemia group I protein isoform X4"
                     /calculated_mol_wt=136250
     Region          1..53
                     /region_name="FANCI_S1-cap"
                     /note="FANCI solenoid 1 cap; pfam14674"
                     /db_xref="CDD:434117"
     Region          43..1175
                     /region_name="FANCI"
                     /note="Fanconi anemia I protein; cd11720"
                     /db_xref="CDD:212594"
     Site            order(48,52,83..84,87,90..91,94..95,98,128,131,182..183,
                     215,219,273,277,280,376,442,446,449,480,483,486..487,490,
                     522..523,526,581..582,585..586,589..590,592..593,616,
                     618..622,625,628,678,689)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:212594"
     Site            order(287,291,294,331,336,339,865,911,963,979,992,1049,
                     1053,1063,1147,1154..1155)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212594"
     CDS             1..1213
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /coded_by="XM_047432823.1:75..3716"
                     /db_xref="GeneID:55215"
                     /db_xref="HGNC:HGNC:25568"
                     /db_xref="MIM:611360"
ORIGIN      
        1 mdqkilslaa ektadklqef lqtlregdlt nllqnqavkg kvagallrai fkgspcseea
       61 gtlrrrkiyt cciqlvesgd lqkeiaseii gllmleahhf pgpllvelan efisavregs
      121 lvngkslell piiltalatk kenlaygkgv lsgeeckkql intlcsgrwd qqyviqltsm
      181 fkdvpltaee vefvvekals mfskmnlqei pplvyqllvl sskgsrksvl egiiaffsal
      241 dkqhneeqsg delldvvtvp sgelrhvegt iilhivfaik ldyelgrelv khlkvgqqgd
      301 snnnlspfsi alllsvtriq rfqdqvldll ktsvvksfkd lqllqgskfl qnlvphrsyv
      361 stmilevvkn svhswdhvtq glvelgfilm dsygpkkvld gktietspsl srmpnqhack
      421 lganilletf kihemirqei leqvlnrvvt rasspishfl dllsnivmya plvlqscssk
      481 vteafdylsf lplqtvqrll kavqpllkvs msmrdclilv lrkamfanql darksavagf
      541 llllknfkvl gslsssqcsq slsvsqvhvd vhshynsvan etfcleimds lrrclsqqad
      601 vrlmlyegfy dvlrrnsqla nsvmqtllsq lkqfyepkpd llpplkleac iltqgdkisl
      661 qepldyllcc iqhclawykn tviplqqgee eeeeeeafye dlddilesit nrmikseled
      721 feldksadfs qstsigiknn icaflvmgvc evlieynfsi ssfrvllwry tsiptsvees
      781 gkkekgksis llcleglqki fsavqqfyqp kiqqflrald vtdkegeere dadvsvtqrt
      841 afqirqfqrs llnllssqee dfnskealll vtvltslskl lepsspqfvq mlswtskick
      901 ensredalfc kslmnllfsl hvsykspvil lrdlsqdihg hlgdidqdve vektnhfaiv
      961 nlrtaaptvc llvlsqaekv leevdwlitk lkgqvsqetl seeassqatl pnqpvekaii
     1021 mqlgtlltff helvqtalps gscvdtllkd lckmyttlta lvryylqvcq ssggipknme
     1081 klvklsgshl tplcysfisy vqnkskslny tgekkekpaa vatamarvlr etkpipnlif
     1141 aieqyekfli hlskkskvnl mqhmklstsr dfkikgnild mvlredgede neegtasehg
     1201 gqnkepakkk rkk
//
LOCUS       XP_047288780            1213 aa            linear   PRI 05-AUG-2025
DEFINITION  Fanconi anemia group I protein isoform X4 [Homo sapiens].
ACCESSION   XP_047288780
VERSION     XP_047288780.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432824.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1213
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1213
                     /product="Fanconi anemia group I protein isoform X4"
                     /calculated_mol_wt=136250
     Region          1..53
                     /region_name="FANCI_S1-cap"
                     /note="FANCI solenoid 1 cap; pfam14674"
                     /db_xref="CDD:434117"
     Region          43..1175
                     /region_name="FANCI"
                     /note="Fanconi anemia I protein; cd11720"
                     /db_xref="CDD:212594"
     Site            order(48,52,83..84,87,90..91,94..95,98,128,131,182..183,
                     215,219,273,277,280,376,442,446,449,480,483,486..487,490,
                     522..523,526,581..582,585..586,589..590,592..593,616,
                     618..622,625,628,678,689)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:212594"
     Site            order(287,291,294,331,336,339,865,911,963,979,992,1049,
                     1053,1063,1147,1154..1155)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212594"
     CDS             1..1213
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /coded_by="XM_047432824.1:109..3750"
                     /db_xref="GeneID:55215"
                     /db_xref="HGNC:HGNC:25568"
                     /db_xref="MIM:611360"
ORIGIN      
        1 mdqkilslaa ektadklqef lqtlregdlt nllqnqavkg kvagallrai fkgspcseea
       61 gtlrrrkiyt cciqlvesgd lqkeiaseii gllmleahhf pgpllvelan efisavregs
      121 lvngkslell piiltalatk kenlaygkgv lsgeeckkql intlcsgrwd qqyviqltsm
      181 fkdvpltaee vefvvekals mfskmnlqei pplvyqllvl sskgsrksvl egiiaffsal
      241 dkqhneeqsg delldvvtvp sgelrhvegt iilhivfaik ldyelgrelv khlkvgqqgd
      301 snnnlspfsi alllsvtriq rfqdqvldll ktsvvksfkd lqllqgskfl qnlvphrsyv
      361 stmilevvkn svhswdhvtq glvelgfilm dsygpkkvld gktietspsl srmpnqhack
      421 lganilletf kihemirqei leqvlnrvvt rasspishfl dllsnivmya plvlqscssk
      481 vteafdylsf lplqtvqrll kavqpllkvs msmrdclilv lrkamfanql darksavagf
      541 llllknfkvl gslsssqcsq slsvsqvhvd vhshynsvan etfcleimds lrrclsqqad
      601 vrlmlyegfy dvlrrnsqla nsvmqtllsq lkqfyepkpd llpplkleac iltqgdkisl
      661 qepldyllcc iqhclawykn tviplqqgee eeeeeeafye dlddilesit nrmikseled
      721 feldksadfs qstsigiknn icaflvmgvc evlieynfsi ssfrvllwry tsiptsvees
      781 gkkekgksis llcleglqki fsavqqfyqp kiqqflrald vtdkegeere dadvsvtqrt
      841 afqirqfqrs llnllssqee dfnskealll vtvltslskl lepsspqfvq mlswtskick
      901 ensredalfc kslmnllfsl hvsykspvil lrdlsqdihg hlgdidqdve vektnhfaiv
      961 nlrtaaptvc llvlsqaekv leevdwlitk lkgqvsqetl seeassqatl pnqpvekaii
     1021 mqlgtlltff helvqtalps gscvdtllkd lckmyttlta lvryylqvcq ssggipknme
     1081 klvklsgshl tplcysfisy vqnkskslny tgekkekpaa vatamarvlr etkpipnlif
     1141 aieqyekfli hlskkskvnl mqhmklstsr dfkikgnild mvlredgede neegtasehg
     1201 gqnkepakkk rkk
//
LOCUS       XP_047288781            1213 aa            linear   PRI 05-AUG-2025
DEFINITION  Fanconi anemia group I protein isoform X4 [Homo sapiens].
ACCESSION   XP_047288781
VERSION     XP_047288781.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432825.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1213
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1213
                     /product="Fanconi anemia group I protein isoform X4"
                     /calculated_mol_wt=136250
     Region          1..53
                     /region_name="FANCI_S1-cap"
                     /note="FANCI solenoid 1 cap; pfam14674"
                     /db_xref="CDD:434117"
     Region          43..1175
                     /region_name="FANCI"
                     /note="Fanconi anemia I protein; cd11720"
                     /db_xref="CDD:212594"
     Site            order(48,52,83..84,87,90..91,94..95,98,128,131,182..183,
                     215,219,273,277,280,376,442,446,449,480,483,486..487,490,
                     522..523,526,581..582,585..586,589..590,592..593,616,
                     618..622,625,628,678,689)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:212594"
     Site            order(287,291,294,331,336,339,865,911,963,979,992,1049,
                     1053,1063,1147,1154..1155)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212594"
     CDS             1..1213
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /coded_by="XM_047432825.1:86..3727"
                     /db_xref="GeneID:55215"
                     /db_xref="HGNC:HGNC:25568"
                     /db_xref="MIM:611360"
ORIGIN      
        1 mdqkilslaa ektadklqef lqtlregdlt nllqnqavkg kvagallrai fkgspcseea
       61 gtlrrrkiyt cciqlvesgd lqkeiaseii gllmleahhf pgpllvelan efisavregs
      121 lvngkslell piiltalatk kenlaygkgv lsgeeckkql intlcsgrwd qqyviqltsm
      181 fkdvpltaee vefvvekals mfskmnlqei pplvyqllvl sskgsrksvl egiiaffsal
      241 dkqhneeqsg delldvvtvp sgelrhvegt iilhivfaik ldyelgrelv khlkvgqqgd
      301 snnnlspfsi alllsvtriq rfqdqvldll ktsvvksfkd lqllqgskfl qnlvphrsyv
      361 stmilevvkn svhswdhvtq glvelgfilm dsygpkkvld gktietspsl srmpnqhack
      421 lganilletf kihemirqei leqvlnrvvt rasspishfl dllsnivmya plvlqscssk
      481 vteafdylsf lplqtvqrll kavqpllkvs msmrdclilv lrkamfanql darksavagf
      541 llllknfkvl gslsssqcsq slsvsqvhvd vhshynsvan etfcleimds lrrclsqqad
      601 vrlmlyegfy dvlrrnsqla nsvmqtllsq lkqfyepkpd llpplkleac iltqgdkisl
      661 qepldyllcc iqhclawykn tviplqqgee eeeeeeafye dlddilesit nrmikseled
      721 feldksadfs qstsigiknn icaflvmgvc evlieynfsi ssfrvllwry tsiptsvees
      781 gkkekgksis llcleglqki fsavqqfyqp kiqqflrald vtdkegeere dadvsvtqrt
      841 afqirqfqrs llnllssqee dfnskealll vtvltslskl lepsspqfvq mlswtskick
      901 ensredalfc kslmnllfsl hvsykspvil lrdlsqdihg hlgdidqdve vektnhfaiv
      961 nlrtaaptvc llvlsqaekv leevdwlitk lkgqvsqetl seeassqatl pnqpvekaii
     1021 mqlgtlltff helvqtalps gscvdtllkd lckmyttlta lvryylqvcq ssggipknme
     1081 klvklsgshl tplcysfisy vqnkskslny tgekkekpaa vatamarvlr etkpipnlif
     1141 aieqyekfli hlskkskvnl mqhmklstsr dfkikgnild mvlredgede neegtasehg
     1201 gqnkepakkk rkk
//
LOCUS       XP_047288782            1213 aa            linear   PRI 05-AUG-2025
DEFINITION  Fanconi anemia group I protein isoform X4 [Homo sapiens].
ACCESSION   XP_047288782
VERSION     XP_047288782.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432826.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1213
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1213
                     /product="Fanconi anemia group I protein isoform X4"
                     /calculated_mol_wt=136250
     Region          1..53
                     /region_name="FANCI_S1-cap"
                     /note="FANCI solenoid 1 cap; pfam14674"
                     /db_xref="CDD:434117"
     Region          43..1175
                     /region_name="FANCI"
                     /note="Fanconi anemia I protein; cd11720"
                     /db_xref="CDD:212594"
     Site            order(48,52,83..84,87,90..91,94..95,98,128,131,182..183,
                     215,219,273,277,280,376,442,446,449,480,483,486..487,490,
                     522..523,526,581..582,585..586,589..590,592..593,616,
                     618..622,625,628,678,689)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:212594"
     Site            order(287,291,294,331,336,339,865,911,963,979,992,1049,
                     1053,1063,1147,1154..1155)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212594"
     CDS             1..1213
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /coded_by="XM_047432826.1:1353..4994"
                     /db_xref="GeneID:55215"
                     /db_xref="HGNC:HGNC:25568"
                     /db_xref="MIM:611360"
ORIGIN      
        1 mdqkilslaa ektadklqef lqtlregdlt nllqnqavkg kvagallrai fkgspcseea
       61 gtlrrrkiyt cciqlvesgd lqkeiaseii gllmleahhf pgpllvelan efisavregs
      121 lvngkslell piiltalatk kenlaygkgv lsgeeckkql intlcsgrwd qqyviqltsm
      181 fkdvpltaee vefvvekals mfskmnlqei pplvyqllvl sskgsrksvl egiiaffsal
      241 dkqhneeqsg delldvvtvp sgelrhvegt iilhivfaik ldyelgrelv khlkvgqqgd
      301 snnnlspfsi alllsvtriq rfqdqvldll ktsvvksfkd lqllqgskfl qnlvphrsyv
      361 stmilevvkn svhswdhvtq glvelgfilm dsygpkkvld gktietspsl srmpnqhack
      421 lganilletf kihemirqei leqvlnrvvt rasspishfl dllsnivmya plvlqscssk
      481 vteafdylsf lplqtvqrll kavqpllkvs msmrdclilv lrkamfanql darksavagf
      541 llllknfkvl gslsssqcsq slsvsqvhvd vhshynsvan etfcleimds lrrclsqqad
      601 vrlmlyegfy dvlrrnsqla nsvmqtllsq lkqfyepkpd llpplkleac iltqgdkisl
      661 qepldyllcc iqhclawykn tviplqqgee eeeeeeafye dlddilesit nrmikseled
      721 feldksadfs qstsigiknn icaflvmgvc evlieynfsi ssfrvllwry tsiptsvees
      781 gkkekgksis llcleglqki fsavqqfyqp kiqqflrald vtdkegeere dadvsvtqrt
      841 afqirqfqrs llnllssqee dfnskealll vtvltslskl lepsspqfvq mlswtskick
      901 ensredalfc kslmnllfsl hvsykspvil lrdlsqdihg hlgdidqdve vektnhfaiv
      961 nlrtaaptvc llvlsqaekv leevdwlitk lkgqvsqetl seeassqatl pnqpvekaii
     1021 mqlgtlltff helvqtalps gscvdtllkd lckmyttlta lvryylqvcq ssggipknme
     1081 klvklsgshl tplcysfisy vqnkskslny tgekkekpaa vatamarvlr etkpipnlif
     1141 aieqyekfli hlskkskvnl mqhmklstsr dfkikgnild mvlredgede neegtasehg
     1201 gqnkepakkk rkk
//
LOCUS       XP_047288783            1213 aa            linear   PRI 05-AUG-2025
DEFINITION  Fanconi anemia group I protein isoform X4 [Homo sapiens].
ACCESSION   XP_047288783
VERSION     XP_047288783.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432827.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1213
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1213
                     /product="Fanconi anemia group I protein isoform X4"
                     /calculated_mol_wt=136250
     Region          1..53
                     /region_name="FANCI_S1-cap"
                     /note="FANCI solenoid 1 cap; pfam14674"
                     /db_xref="CDD:434117"
     Region          43..1175
                     /region_name="FANCI"
                     /note="Fanconi anemia I protein; cd11720"
                     /db_xref="CDD:212594"
     Site            order(48,52,83..84,87,90..91,94..95,98,128,131,182..183,
                     215,219,273,277,280,376,442,446,449,480,483,486..487,490,
                     522..523,526,581..582,585..586,589..590,592..593,616,
                     618..622,625,628,678,689)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:212594"
     Site            order(287,291,294,331,336,339,865,911,963,979,992,1049,
                     1053,1063,1147,1154..1155)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212594"
     CDS             1..1213
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /coded_by="XM_047432827.1:322..3963"
                     /db_xref="GeneID:55215"
                     /db_xref="HGNC:HGNC:25568"
                     /db_xref="MIM:611360"
ORIGIN      
        1 mdqkilslaa ektadklqef lqtlregdlt nllqnqavkg kvagallrai fkgspcseea
       61 gtlrrrkiyt cciqlvesgd lqkeiaseii gllmleahhf pgpllvelan efisavregs
      121 lvngkslell piiltalatk kenlaygkgv lsgeeckkql intlcsgrwd qqyviqltsm
      181 fkdvpltaee vefvvekals mfskmnlqei pplvyqllvl sskgsrksvl egiiaffsal
      241 dkqhneeqsg delldvvtvp sgelrhvegt iilhivfaik ldyelgrelv khlkvgqqgd
      301 snnnlspfsi alllsvtriq rfqdqvldll ktsvvksfkd lqllqgskfl qnlvphrsyv
      361 stmilevvkn svhswdhvtq glvelgfilm dsygpkkvld gktietspsl srmpnqhack
      421 lganilletf kihemirqei leqvlnrvvt rasspishfl dllsnivmya plvlqscssk
      481 vteafdylsf lplqtvqrll kavqpllkvs msmrdclilv lrkamfanql darksavagf
      541 llllknfkvl gslsssqcsq slsvsqvhvd vhshynsvan etfcleimds lrrclsqqad
      601 vrlmlyegfy dvlrrnsqla nsvmqtllsq lkqfyepkpd llpplkleac iltqgdkisl
      661 qepldyllcc iqhclawykn tviplqqgee eeeeeeafye dlddilesit nrmikseled
      721 feldksadfs qstsigiknn icaflvmgvc evlieynfsi ssfrvllwry tsiptsvees
      781 gkkekgksis llcleglqki fsavqqfyqp kiqqflrald vtdkegeere dadvsvtqrt
      841 afqirqfqrs llnllssqee dfnskealll vtvltslskl lepsspqfvq mlswtskick
      901 ensredalfc kslmnllfsl hvsykspvil lrdlsqdihg hlgdidqdve vektnhfaiv
      961 nlrtaaptvc llvlsqaekv leevdwlitk lkgqvsqetl seeassqatl pnqpvekaii
     1021 mqlgtlltff helvqtalps gscvdtllkd lckmyttlta lvryylqvcq ssggipknme
     1081 klvklsgshl tplcysfisy vqnkskslny tgekkekpaa vatamarvlr etkpipnlif
     1141 aieqyekfli hlskkskvnl mqhmklstsr dfkikgnild mvlredgede neegtasehg
     1201 gqnkepakkk rkk
//
LOCUS       XP_047288784            1213 aa            linear   PRI 05-AUG-2025
DEFINITION  Fanconi anemia group I protein isoform X4 [Homo sapiens].
ACCESSION   XP_047288784
VERSION     XP_047288784.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432828.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1213
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1213
                     /product="Fanconi anemia group I protein isoform X4"
                     /calculated_mol_wt=136250
     Region          1..53
                     /region_name="FANCI_S1-cap"
                     /note="FANCI solenoid 1 cap; pfam14674"
                     /db_xref="CDD:434117"
     Region          43..1175
                     /region_name="FANCI"
                     /note="Fanconi anemia I protein; cd11720"
                     /db_xref="CDD:212594"
     Site            order(48,52,83..84,87,90..91,94..95,98,128,131,182..183,
                     215,219,273,277,280,376,442,446,449,480,483,486..487,490,
                     522..523,526,581..582,585..586,589..590,592..593,616,
                     618..622,625,628,678,689)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:212594"
     Site            order(287,291,294,331,336,339,865,911,963,979,992,1049,
                     1053,1063,1147,1154..1155)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212594"
     CDS             1..1213
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /coded_by="XM_047432828.1:211..3852"
                     /db_xref="GeneID:55215"
                     /db_xref="HGNC:HGNC:25568"
                     /db_xref="MIM:611360"
ORIGIN      
        1 mdqkilslaa ektadklqef lqtlregdlt nllqnqavkg kvagallrai fkgspcseea
       61 gtlrrrkiyt cciqlvesgd lqkeiaseii gllmleahhf pgpllvelan efisavregs
      121 lvngkslell piiltalatk kenlaygkgv lsgeeckkql intlcsgrwd qqyviqltsm
      181 fkdvpltaee vefvvekals mfskmnlqei pplvyqllvl sskgsrksvl egiiaffsal
      241 dkqhneeqsg delldvvtvp sgelrhvegt iilhivfaik ldyelgrelv khlkvgqqgd
      301 snnnlspfsi alllsvtriq rfqdqvldll ktsvvksfkd lqllqgskfl qnlvphrsyv
      361 stmilevvkn svhswdhvtq glvelgfilm dsygpkkvld gktietspsl srmpnqhack
      421 lganilletf kihemirqei leqvlnrvvt rasspishfl dllsnivmya plvlqscssk
      481 vteafdylsf lplqtvqrll kavqpllkvs msmrdclilv lrkamfanql darksavagf
      541 llllknfkvl gslsssqcsq slsvsqvhvd vhshynsvan etfcleimds lrrclsqqad
      601 vrlmlyegfy dvlrrnsqla nsvmqtllsq lkqfyepkpd llpplkleac iltqgdkisl
      661 qepldyllcc iqhclawykn tviplqqgee eeeeeeafye dlddilesit nrmikseled
      721 feldksadfs qstsigiknn icaflvmgvc evlieynfsi ssfrvllwry tsiptsvees
      781 gkkekgksis llcleglqki fsavqqfyqp kiqqflrald vtdkegeere dadvsvtqrt
      841 afqirqfqrs llnllssqee dfnskealll vtvltslskl lepsspqfvq mlswtskick
      901 ensredalfc kslmnllfsl hvsykspvil lrdlsqdihg hlgdidqdve vektnhfaiv
      961 nlrtaaptvc llvlsqaekv leevdwlitk lkgqvsqetl seeassqatl pnqpvekaii
     1021 mqlgtlltff helvqtalps gscvdtllkd lckmyttlta lvryylqvcq ssggipknme
     1081 klvklsgshl tplcysfisy vqnkskslny tgekkekpaa vatamarvlr etkpipnlif
     1141 aieqyekfli hlskkskvnl mqhmklstsr dfkikgnild mvlredgede neegtasehg
     1201 gqnkepakkk rkk
//
LOCUS       XP_047288785            1213 aa            linear   PRI 05-AUG-2025
DEFINITION  Fanconi anemia group I protein isoform X4 [Homo sapiens].
ACCESSION   XP_047288785
VERSION     XP_047288785.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432829.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1213
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1213
                     /product="Fanconi anemia group I protein isoform X4"
                     /calculated_mol_wt=136250
     Region          1..53
                     /region_name="FANCI_S1-cap"
                     /note="FANCI solenoid 1 cap; pfam14674"
                     /db_xref="CDD:434117"
     Region          43..1175
                     /region_name="FANCI"
                     /note="Fanconi anemia I protein; cd11720"
                     /db_xref="CDD:212594"
     Site            order(48,52,83..84,87,90..91,94..95,98,128,131,182..183,
                     215,219,273,277,280,376,442,446,449,480,483,486..487,490,
                     522..523,526,581..582,585..586,589..590,592..593,616,
                     618..622,625,628,678,689)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:212594"
     Site            order(287,291,294,331,336,339,865,911,963,979,992,1049,
                     1053,1063,1147,1154..1155)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212594"
     CDS             1..1213
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /coded_by="XM_047432829.1:159..3800"
                     /db_xref="GeneID:55215"
                     /db_xref="HGNC:HGNC:25568"
                     /db_xref="MIM:611360"
ORIGIN      
        1 mdqkilslaa ektadklqef lqtlregdlt nllqnqavkg kvagallrai fkgspcseea
       61 gtlrrrkiyt cciqlvesgd lqkeiaseii gllmleahhf pgpllvelan efisavregs
      121 lvngkslell piiltalatk kenlaygkgv lsgeeckkql intlcsgrwd qqyviqltsm
      181 fkdvpltaee vefvvekals mfskmnlqei pplvyqllvl sskgsrksvl egiiaffsal
      241 dkqhneeqsg delldvvtvp sgelrhvegt iilhivfaik ldyelgrelv khlkvgqqgd
      301 snnnlspfsi alllsvtriq rfqdqvldll ktsvvksfkd lqllqgskfl qnlvphrsyv
      361 stmilevvkn svhswdhvtq glvelgfilm dsygpkkvld gktietspsl srmpnqhack
      421 lganilletf kihemirqei leqvlnrvvt rasspishfl dllsnivmya plvlqscssk
      481 vteafdylsf lplqtvqrll kavqpllkvs msmrdclilv lrkamfanql darksavagf
      541 llllknfkvl gslsssqcsq slsvsqvhvd vhshynsvan etfcleimds lrrclsqqad
      601 vrlmlyegfy dvlrrnsqla nsvmqtllsq lkqfyepkpd llpplkleac iltqgdkisl
      661 qepldyllcc iqhclawykn tviplqqgee eeeeeeafye dlddilesit nrmikseled
      721 feldksadfs qstsigiknn icaflvmgvc evlieynfsi ssfrvllwry tsiptsvees
      781 gkkekgksis llcleglqki fsavqqfyqp kiqqflrald vtdkegeere dadvsvtqrt
      841 afqirqfqrs llnllssqee dfnskealll vtvltslskl lepsspqfvq mlswtskick
      901 ensredalfc kslmnllfsl hvsykspvil lrdlsqdihg hlgdidqdve vektnhfaiv
      961 nlrtaaptvc llvlsqaekv leevdwlitk lkgqvsqetl seeassqatl pnqpvekaii
     1021 mqlgtlltff helvqtalps gscvdtllkd lckmyttlta lvryylqvcq ssggipknme
     1081 klvklsgshl tplcysfisy vqnkskslny tgekkekpaa vatamarvlr etkpipnlif
     1141 aieqyekfli hlskkskvnl mqhmklstsr dfkikgnild mvlredgede neegtasehg
     1201 gqnkepakkk rkk
//
LOCUS       XP_047288786            1213 aa            linear   PRI 05-AUG-2025
DEFINITION  Fanconi anemia group I protein isoform X4 [Homo sapiens].
ACCESSION   XP_047288786
VERSION     XP_047288786.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432830.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1213
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1213
                     /product="Fanconi anemia group I protein isoform X4"
                     /calculated_mol_wt=136250
     Region          1..53
                     /region_name="FANCI_S1-cap"
                     /note="FANCI solenoid 1 cap; pfam14674"
                     /db_xref="CDD:434117"
     Region          43..1175
                     /region_name="FANCI"
                     /note="Fanconi anemia I protein; cd11720"
                     /db_xref="CDD:212594"
     Site            order(48,52,83..84,87,90..91,94..95,98,128,131,182..183,
                     215,219,273,277,280,376,442,446,449,480,483,486..487,490,
                     522..523,526,581..582,585..586,589..590,592..593,616,
                     618..622,625,628,678,689)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:212594"
     Site            order(287,291,294,331,336,339,865,911,963,979,992,1049,
                     1053,1063,1147,1154..1155)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212594"
     CDS             1..1213
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /coded_by="XM_047432830.1:1891..5532"
                     /db_xref="GeneID:55215"
                     /db_xref="HGNC:HGNC:25568"
                     /db_xref="MIM:611360"
ORIGIN      
        1 mdqkilslaa ektadklqef lqtlregdlt nllqnqavkg kvagallrai fkgspcseea
       61 gtlrrrkiyt cciqlvesgd lqkeiaseii gllmleahhf pgpllvelan efisavregs
      121 lvngkslell piiltalatk kenlaygkgv lsgeeckkql intlcsgrwd qqyviqltsm
      181 fkdvpltaee vefvvekals mfskmnlqei pplvyqllvl sskgsrksvl egiiaffsal
      241 dkqhneeqsg delldvvtvp sgelrhvegt iilhivfaik ldyelgrelv khlkvgqqgd
      301 snnnlspfsi alllsvtriq rfqdqvldll ktsvvksfkd lqllqgskfl qnlvphrsyv
      361 stmilevvkn svhswdhvtq glvelgfilm dsygpkkvld gktietspsl srmpnqhack
      421 lganilletf kihemirqei leqvlnrvvt rasspishfl dllsnivmya plvlqscssk
      481 vteafdylsf lplqtvqrll kavqpllkvs msmrdclilv lrkamfanql darksavagf
      541 llllknfkvl gslsssqcsq slsvsqvhvd vhshynsvan etfcleimds lrrclsqqad
      601 vrlmlyegfy dvlrrnsqla nsvmqtllsq lkqfyepkpd llpplkleac iltqgdkisl
      661 qepldyllcc iqhclawykn tviplqqgee eeeeeeafye dlddilesit nrmikseled
      721 feldksadfs qstsigiknn icaflvmgvc evlieynfsi ssfrvllwry tsiptsvees
      781 gkkekgksis llcleglqki fsavqqfyqp kiqqflrald vtdkegeere dadvsvtqrt
      841 afqirqfqrs llnllssqee dfnskealll vtvltslskl lepsspqfvq mlswtskick
      901 ensredalfc kslmnllfsl hvsykspvil lrdlsqdihg hlgdidqdve vektnhfaiv
      961 nlrtaaptvc llvlsqaekv leevdwlitk lkgqvsqetl seeassqatl pnqpvekaii
     1021 mqlgtlltff helvqtalps gscvdtllkd lckmyttlta lvryylqvcq ssggipknme
     1081 klvklsgshl tplcysfisy vqnkskslny tgekkekpaa vatamarvlr etkpipnlif
     1141 aieqyekfli hlskkskvnl mqhmklstsr dfkikgnild mvlredgede neegtasehg
     1201 gqnkepakkk rkk
//
LOCUS       XP_047288787            1213 aa            linear   PRI 05-AUG-2025
DEFINITION  Fanconi anemia group I protein isoform X4 [Homo sapiens].
ACCESSION   XP_047288787
VERSION     XP_047288787.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432831.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1213
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1213
                     /product="Fanconi anemia group I protein isoform X4"
                     /calculated_mol_wt=136250
     Region          1..53
                     /region_name="FANCI_S1-cap"
                     /note="FANCI solenoid 1 cap; pfam14674"
                     /db_xref="CDD:434117"
     Region          43..1175
                     /region_name="FANCI"
                     /note="Fanconi anemia I protein; cd11720"
                     /db_xref="CDD:212594"
     Site            order(48,52,83..84,87,90..91,94..95,98,128,131,182..183,
                     215,219,273,277,280,376,442,446,449,480,483,486..487,490,
                     522..523,526,581..582,585..586,589..590,592..593,616,
                     618..622,625,628,678,689)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:212594"
     Site            order(287,291,294,331,336,339,865,911,963,979,992,1049,
                     1053,1063,1147,1154..1155)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212594"
     CDS             1..1213
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /coded_by="XM_047432831.1:193..3834"
                     /db_xref="GeneID:55215"
                     /db_xref="HGNC:HGNC:25568"
                     /db_xref="MIM:611360"
ORIGIN      
        1 mdqkilslaa ektadklqef lqtlregdlt nllqnqavkg kvagallrai fkgspcseea
       61 gtlrrrkiyt cciqlvesgd lqkeiaseii gllmleahhf pgpllvelan efisavregs
      121 lvngkslell piiltalatk kenlaygkgv lsgeeckkql intlcsgrwd qqyviqltsm
      181 fkdvpltaee vefvvekals mfskmnlqei pplvyqllvl sskgsrksvl egiiaffsal
      241 dkqhneeqsg delldvvtvp sgelrhvegt iilhivfaik ldyelgrelv khlkvgqqgd
      301 snnnlspfsi alllsvtriq rfqdqvldll ktsvvksfkd lqllqgskfl qnlvphrsyv
      361 stmilevvkn svhswdhvtq glvelgfilm dsygpkkvld gktietspsl srmpnqhack
      421 lganilletf kihemirqei leqvlnrvvt rasspishfl dllsnivmya plvlqscssk
      481 vteafdylsf lplqtvqrll kavqpllkvs msmrdclilv lrkamfanql darksavagf
      541 llllknfkvl gslsssqcsq slsvsqvhvd vhshynsvan etfcleimds lrrclsqqad
      601 vrlmlyegfy dvlrrnsqla nsvmqtllsq lkqfyepkpd llpplkleac iltqgdkisl
      661 qepldyllcc iqhclawykn tviplqqgee eeeeeeafye dlddilesit nrmikseled
      721 feldksadfs qstsigiknn icaflvmgvc evlieynfsi ssfrvllwry tsiptsvees
      781 gkkekgksis llcleglqki fsavqqfyqp kiqqflrald vtdkegeere dadvsvtqrt
      841 afqirqfqrs llnllssqee dfnskealll vtvltslskl lepsspqfvq mlswtskick
      901 ensredalfc kslmnllfsl hvsykspvil lrdlsqdihg hlgdidqdve vektnhfaiv
      961 nlrtaaptvc llvlsqaekv leevdwlitk lkgqvsqetl seeassqatl pnqpvekaii
     1021 mqlgtlltff helvqtalps gscvdtllkd lckmyttlta lvryylqvcq ssggipknme
     1081 klvklsgshl tplcysfisy vqnkskslny tgekkekpaa vatamarvlr etkpipnlif
     1141 aieqyekfli hlskkskvnl mqhmklstsr dfkikgnild mvlredgede neegtasehg
     1201 gqnkepakkk rkk
//
LOCUS       XP_047288788            1213 aa            linear   PRI 05-AUG-2025
DEFINITION  Fanconi anemia group I protein isoform X4 [Homo sapiens].
ACCESSION   XP_047288788
VERSION     XP_047288788.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432832.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1213
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1213
                     /product="Fanconi anemia group I protein isoform X4"
                     /calculated_mol_wt=136250
     Region          1..53
                     /region_name="FANCI_S1-cap"
                     /note="FANCI solenoid 1 cap; pfam14674"
                     /db_xref="CDD:434117"
     Region          43..1175
                     /region_name="FANCI"
                     /note="Fanconi anemia I protein; cd11720"
                     /db_xref="CDD:212594"
     Site            order(48,52,83..84,87,90..91,94..95,98,128,131,182..183,
                     215,219,273,277,280,376,442,446,449,480,483,486..487,490,
                     522..523,526,581..582,585..586,589..590,592..593,616,
                     618..622,625,628,678,689)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:212594"
     Site            order(287,291,294,331,336,339,865,911,963,979,992,1049,
                     1053,1063,1147,1154..1155)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212594"
     CDS             1..1213
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /coded_by="XM_047432832.1:308..3949"
                     /db_xref="GeneID:55215"
                     /db_xref="HGNC:HGNC:25568"
                     /db_xref="MIM:611360"
ORIGIN      
        1 mdqkilslaa ektadklqef lqtlregdlt nllqnqavkg kvagallrai fkgspcseea
       61 gtlrrrkiyt cciqlvesgd lqkeiaseii gllmleahhf pgpllvelan efisavregs
      121 lvngkslell piiltalatk kenlaygkgv lsgeeckkql intlcsgrwd qqyviqltsm
      181 fkdvpltaee vefvvekals mfskmnlqei pplvyqllvl sskgsrksvl egiiaffsal
      241 dkqhneeqsg delldvvtvp sgelrhvegt iilhivfaik ldyelgrelv khlkvgqqgd
      301 snnnlspfsi alllsvtriq rfqdqvldll ktsvvksfkd lqllqgskfl qnlvphrsyv
      361 stmilevvkn svhswdhvtq glvelgfilm dsygpkkvld gktietspsl srmpnqhack
      421 lganilletf kihemirqei leqvlnrvvt rasspishfl dllsnivmya plvlqscssk
      481 vteafdylsf lplqtvqrll kavqpllkvs msmrdclilv lrkamfanql darksavagf
      541 llllknfkvl gslsssqcsq slsvsqvhvd vhshynsvan etfcleimds lrrclsqqad
      601 vrlmlyegfy dvlrrnsqla nsvmqtllsq lkqfyepkpd llpplkleac iltqgdkisl
      661 qepldyllcc iqhclawykn tviplqqgee eeeeeeafye dlddilesit nrmikseled
      721 feldksadfs qstsigiknn icaflvmgvc evlieynfsi ssfrvllwry tsiptsvees
      781 gkkekgksis llcleglqki fsavqqfyqp kiqqflrald vtdkegeere dadvsvtqrt
      841 afqirqfqrs llnllssqee dfnskealll vtvltslskl lepsspqfvq mlswtskick
      901 ensredalfc kslmnllfsl hvsykspvil lrdlsqdihg hlgdidqdve vektnhfaiv
      961 nlrtaaptvc llvlsqaekv leevdwlitk lkgqvsqetl seeassqatl pnqpvekaii
     1021 mqlgtlltff helvqtalps gscvdtllkd lckmyttlta lvryylqvcq ssggipknme
     1081 klvklsgshl tplcysfisy vqnkskslny tgekkekpaa vatamarvlr etkpipnlif
     1141 aieqyekfli hlskkskvnl mqhmklstsr dfkikgnild mvlredgede neegtasehg
     1201 gqnkepakkk rkk
//
LOCUS       XP_047288789            1213 aa            linear   PRI 05-AUG-2025
DEFINITION  Fanconi anemia group I protein isoform X4 [Homo sapiens].
ACCESSION   XP_047288789
VERSION     XP_047288789.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432833.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1213
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1213
                     /product="Fanconi anemia group I protein isoform X4"
                     /calculated_mol_wt=136250
     Region          1..53
                     /region_name="FANCI_S1-cap"
                     /note="FANCI solenoid 1 cap; pfam14674"
                     /db_xref="CDD:434117"
     Region          43..1175
                     /region_name="FANCI"
                     /note="Fanconi anemia I protein; cd11720"
                     /db_xref="CDD:212594"
     Site            order(48,52,83..84,87,90..91,94..95,98,128,131,182..183,
                     215,219,273,277,280,376,442,446,449,480,483,486..487,490,
                     522..523,526,581..582,585..586,589..590,592..593,616,
                     618..622,625,628,678,689)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:212594"
     Site            order(287,291,294,331,336,339,865,911,963,979,992,1049,
                     1053,1063,1147,1154..1155)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:212594"
     CDS             1..1213
                     /gene="FANCI"
                     /gene_synonym="KIAA1794"
                     /coded_by="XM_047432833.1:188..3829"
                     /db_xref="GeneID:55215"
                     /db_xref="HGNC:HGNC:25568"
                     /db_xref="MIM:611360"
ORIGIN      
        1 mdqkilslaa ektadklqef lqtlregdlt nllqnqavkg kvagallrai fkgspcseea
       61 gtlrrrkiyt cciqlvesgd lqkeiaseii gllmleahhf pgpllvelan efisavregs
      121 lvngkslell piiltalatk kenlaygkgv lsgeeckkql intlcsgrwd qqyviqltsm
      181 fkdvpltaee vefvvekals mfskmnlqei pplvyqllvl sskgsrksvl egiiaffsal
      241 dkqhneeqsg delldvvtvp sgelrhvegt iilhivfaik ldyelgrelv khlkvgqqgd
      301 snnnlspfsi alllsvtriq rfqdqvldll ktsvvksfkd lqllqgskfl qnlvphrsyv
      361 stmilevvkn svhswdhvtq glvelgfilm dsygpkkvld gktietspsl srmpnqhack
      421 lganilletf kihemirqei leqvlnrvvt rasspishfl dllsnivmya plvlqscssk
      481 vteafdylsf lplqtvqrll kavqpllkvs msmrdclilv lrkamfanql darksavagf
      541 llllknfkvl gslsssqcsq slsvsqvhvd vhshynsvan etfcleimds lrrclsqqad
      601 vrlmlyegfy dvlrrnsqla nsvmqtllsq lkqfyepkpd llpplkleac iltqgdkisl
      661 qepldyllcc iqhclawykn tviplqqgee eeeeeeafye dlddilesit nrmikseled
      721 feldksadfs qstsigiknn icaflvmgvc evlieynfsi ssfrvllwry tsiptsvees
      781 gkkekgksis llcleglqki fsavqqfyqp kiqqflrald vtdkegeere dadvsvtqrt
      841 afqirqfqrs llnllssqee dfnskealll vtvltslskl lepsspqfvq mlswtskick
      901 ensredalfc kslmnllfsl hvsykspvil lrdlsqdihg hlgdidqdve vektnhfaiv
      961 nlrtaaptvc llvlsqaekv leevdwlitk lkgqvsqetl seeassqatl pnqpvekaii
     1021 mqlgtlltff helvqtalps gscvdtllkd lckmyttlta lvryylqvcq ssggipknme
     1081 klvklsgshl tplcysfisy vqnkskslny tgekkekpaa vatamarvlr etkpipnlif
     1141 aieqyekfli hlskkskvnl mqhmklstsr dfkikgnild mvlredgede neegtasehg
     1201 gqnkepakkk rkk
//
LOCUS       XP_047288790             312 aa            linear   PRI 05-AUG-2025
DEFINITION  dnaJ homolog subfamily A member 4 isoform X1 [Homo sapiens].
ACCESSION   XP_047288790
VERSION     XP_047288790.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432834.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..312
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..312
                     /product="dnaJ homolog subfamily A member 4 isoform X1"
                     /calculated_mol_wt=35190
     Region          <2..309
                     /region_name="PTZ00037"
                     /note="DnaJ_C chaperone protein; Provisional"
                     /db_xref="CDD:240236"
     CDS             1..312
                     /gene="DNAJA4"
                     /gene_synonym="MST104; MSTP104; PRO1472"
                     /coded_by="XM_047432834.1:373..1311"
                     /db_xref="GeneID:55466"
                     /db_xref="HGNC:HGNC:14885"
ORIGIN      
        1 mdifdmffgg ggrmarerrg knvvhqlsvt ledlyngvtk klalqknvic ekcegvggkk
       61 gsvekcplck grgmqihiqq igpgmvqqiq tvcieckgqg erinpkdrce scsgakvire
      121 kkiievhvek gmkdgqkilf hgegdqepel epgdviivld qkdhsvfqrr ghdlimkmki
      181 qlsealcgfk ktiktldnri lvitskagev ikhgdlrcvr degmpiykap lekgiliiqf
      241 lvifpekhwl sleklpqlea llpprqkvri tddmdqvelk efcpneqnwr qhreayeede
      301 dgpqagvqcq ta
//
LOCUS       XP_047288791             312 aa            linear   PRI 05-AUG-2025
DEFINITION  dnaJ homolog subfamily A member 4 isoform X1 [Homo sapiens].
ACCESSION   XP_047288791
VERSION     XP_047288791.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432835.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..312
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..312
                     /product="dnaJ homolog subfamily A member 4 isoform X1"
                     /calculated_mol_wt=35190
     Region          <2..309
                     /region_name="PTZ00037"
                     /note="DnaJ_C chaperone protein; Provisional"
                     /db_xref="CDD:240236"
     CDS             1..312
                     /gene="DNAJA4"
                     /gene_synonym="MST104; MSTP104; PRO1472"
                     /coded_by="XM_047432835.1:3842..4780"
                     /db_xref="GeneID:55466"
                     /db_xref="HGNC:HGNC:14885"
ORIGIN      
        1 mdifdmffgg ggrmarerrg knvvhqlsvt ledlyngvtk klalqknvic ekcegvggkk
       61 gsvekcplck grgmqihiqq igpgmvqqiq tvcieckgqg erinpkdrce scsgakvire
      121 kkiievhvek gmkdgqkilf hgegdqepel epgdviivld qkdhsvfqrr ghdlimkmki
      181 qlsealcgfk ktiktldnri lvitskagev ikhgdlrcvr degmpiykap lekgiliiqf
      241 lvifpekhwl sleklpqlea llpprqkvri tddmdqvelk efcpneqnwr qhreayeede
      301 dgpqagvqcq ta
//
LOCUS       XP_047288792             444 aa            linear   PRI 05-AUG-2025
DEFINITION  dnaJ homolog subfamily A member 4 isoform X2 [Homo sapiens].
ACCESSION   XP_047288792
VERSION     XP_047288792.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432836.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..444
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..444
                     /product="dnaJ homolog subfamily A member 4 isoform X2"
                     /calculated_mol_wt=49779
     Region          15..441
                     /region_name="PTZ00037"
                     /note="DnaJ_C chaperone protein; Provisional"
                     /db_xref="CDD:240236"
     CDS             1..444
                     /gene="DNAJA4"
                     /gene_synonym="MST104; MSTP104; PRO1472"
                     /coded_by="XM_047432836.1:170..1504"
                     /db_xref="GeneID:55466"
                     /db_xref="HGNC:HGNC:14885"
ORIGIN      
        1 marggsqsws sgesdgqpke qtpekprhkm vketqyydil gvkpsaspee ikkayrklal
       61 kyhpdknpde gekghghlqp dislysysgf sfklisqaye vlsdpkkrdv ydqggeqaik
      121 eggsgspsfs spmdifdmff ggggrmarer rgknvvhqls vtledlyngv tkklalqknv
      181 icekcegvgg kkgsvekcpl ckgrgmqihi qqigpgmvqq iqtvcieckg qgerinpkdr
      241 cescsgakvi rekkiievhv ekgmkdgqki lfhgegdqep elepgdviiv ldqkdhsvfq
      301 rrghdlimkm kiqlsealcg fkktiktldn rilvitskag evikhgdlrc vrdegmpiyk
      361 aplekgilii qflvifpekh wlsleklpql eallpprqkv ritddmdqve lkefcpneqn
      421 wrqhreayee dedgpqagvq cqta
//
LOCUS       XP_047288795             878 aa            linear   PRI 05-AUG-2025
DEFINITION  multiple C2 and transmembrane domain-containing protein 2 isoform
            X5 [Homo sapiens].
ACCESSION   XP_047288795
VERSION     XP_047288795.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432839.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..878
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..878
                     /product="multiple C2 and transmembrane domain-containing
                     protein 2 isoform X5"
                     /calculated_mol_wt=99465
     Region          195..314
                     /region_name="C2A_MCTP_PRT"
                     /note="C2 domain first repeat found in Multiple C2 domain
                     and Transmembrane region Proteins (MCTP); cd04042"
                     /db_xref="CDD:176007"
     Site            order(210,216,263,265,270)
                     /site_type="other"
                     /note="putative Ca2+ binding site [ion binding]"
                     /db_xref="CDD:176007"
     Region          357..469
                     /region_name="C2B_MCTP_PRT"
                     /note="C2 domain second repeat found in Multiple C2 domain
                     and Transmembrane region Proteins (MCTP); cd08376"
                     /db_xref="CDD:176022"
     Site            order(375,422,424,430)
                     /site_type="other"
                     /note="putative Ca2+ binding site [ion binding]"
                     /db_xref="CDD:176022"
     Region          509..627
                     /region_name="C2C_MCTP_PRT"
                     /note="C2 domain third repeat found in Multiple C2 domain
                     and Transmembrane region Proteins (MCTP); cd08377"
                     /db_xref="CDD:176023"
     Site            order(525,531,577,579,585)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:176023"
     Region          <771..>824
                     /region_name="PRT_C"
                     /note="Plant phosphoribosyltransferase C-terminal;
                     pfam08372"
                     /db_xref="CDD:337028"
     CDS             1..878
                     /gene="MCTP2"
                     /coded_by="XM_047432839.1:156..2792"
                     /db_xref="GeneID:55784"
                     /db_xref="HGNC:HGNC:25636"
                     /db_xref="MIM:616297"
ORIGIN      
        1 mdldkpsvwg slkqrtrpll inlskkkvkk npskppdlra rhhldrrlsl svpdlleaea
       61 lapegrpysg pqssytsvps slstagifpk ssssslkqse eeldwsqeea shlhvvetds
      121 eeayaspaer rrvssngifd lqktslggda peepeklcgs sdlnasmtsq hfeeqsvpge
      181 asdglsnlps pfaylltihl kegrnlvvrd rcgtsdpyvk fklngktlyk skviyknlnp
      241 vwdeivvlpi qsldqklrvk vydrdlttsd fmgsafvils dlelnrtteh ilkledpnsl
      301 eddmgvivln lnlvvkqgdf krhrwsnrkr lsasksslir nlrlseslkk nqlwngiisi
      361 tllegknvsg gsmtemfvql klgdqryksk tlcksanpqw qeqfdfhyfs drmgildiev
      421 wgkdnkkhee rlgtckvdis alplkqancl elpldsclga llmlvtltpc agvsvsdlcv
      481 cpladlserk qitqryclqn slkdvkdvgi lqvkvlkaad llaadfsgks dpfcllelgn
      541 drlqthtvyk nlnpewnkvf tfpikdihdv levtvfdedg dkppdflgkv aipllsirdg
      601 qpncyvlknk dleqafkgvi ylemdliynp vkasirtftp rekrfvedsr klskkilsrd
      661 vdrvkritma iwntmqflks cfqwestlrs tiafavflit vwnfelymip lalllifvyn
      721 firpvkgkvs siqdsqestd iddeededdk esekkglier iymvqdivst vqnvleeias
      781 fgerikntfn wtvpflssla clilaaatii lyfiplryii liwginkftk klrnpysidn
      841 nelldflsrv psdvqkvqya elklcsshsp lrkkrsal
//
LOCUS       XP_047288796             823 aa            linear   PRI 05-AUG-2025
DEFINITION  multiple C2 and transmembrane domain-containing protein 2 isoform
            X1 [Homo sapiens].
ACCESSION   XP_047288796
VERSION     XP_047288796.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432840.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..823
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..823
                     /product="multiple C2 and transmembrane domain-containing
                     protein 2 isoform X1"
                     /calculated_mol_wt=93029
     Region          195..314
                     /region_name="C2A_MCTP_PRT"
                     /note="C2 domain first repeat found in Multiple C2 domain
                     and Transmembrane region Proteins (MCTP); cd04042"
                     /db_xref="CDD:176007"
     Site            order(210,216,263,265,270)
                     /site_type="other"
                     /note="putative Ca2+ binding site [ion binding]"
                     /db_xref="CDD:176007"
     Region          357..469
                     /region_name="C2B_MCTP_PRT"
                     /note="C2 domain second repeat found in Multiple C2 domain
                     and Transmembrane region Proteins (MCTP); cd08376"
                     /db_xref="CDD:176022"
     Site            order(375,422,424,430)
                     /site_type="other"
                     /note="putative Ca2+ binding site [ion binding]"
                     /db_xref="CDD:176022"
     Region          509..627
                     /region_name="C2C_MCTP_PRT"
                     /note="C2 domain third repeat found in Multiple C2 domain
                     and Transmembrane region Proteins (MCTP); cd08377"
                     /db_xref="CDD:176023"
     Site            order(525,531,577,579,585)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:176023"
     Region          <716..>769
                     /region_name="PRT_C"
                     /note="Plant phosphoribosyltransferase C-terminal;
                     pfam08372"
                     /db_xref="CDD:337028"
     CDS             1..823
                     /gene="MCTP2"
                     /coded_by="XM_047432840.1:156..2627"
                     /db_xref="GeneID:55784"
                     /db_xref="HGNC:HGNC:25636"
                     /db_xref="MIM:616297"
ORIGIN      
        1 mdldkpsvwg slkqrtrpll inlskkkvkk npskppdlra rhhldrrlsl svpdlleaea
       61 lapegrpysg pqssytsvps slstagifpk ssssslkqse eeldwsqeea shlhvvetds
      121 eeayaspaer rrvssngifd lqktslggda peepeklcgs sdlnasmtsq hfeeqsvpge
      181 asdglsnlps pfaylltihl kegrnlvvrd rcgtsdpyvk fklngktlyk skviyknlnp
      241 vwdeivvlpi qsldqklrvk vydrdlttsd fmgsafvils dlelnrtteh ilkledpnsl
      301 eddmgvivln lnlvvkqgdf krhrwsnrkr lsasksslir nlrlseslkk nqlwngiisi
      361 tllegknvsg gsmtemfvql klgdqryksk tlcksanpqw qeqfdfhyfs drmgildiev
      421 wgkdnkkhee rlgtckvdis alplkqancl elpldsclga llmlvtltpc agvsvsdlcv
      481 cpladlserk qitqryclqn slkdvkdvgi lqvkvlkaad llaadfsgks dpfcllelgn
      541 drlqthtvyk nlnpewnkvf tfpikdihdv levtvfdedg dkppdflgkv aipllsirdg
      601 qpncyvlknk dleqafkgvi ylemdliynp vkasirtftp rekrfvedsr klskkilsrd
      661 vdrvkritma iwntmqflks cfqwestlrs tiafaesekk glieriymvq divstvqnvl
      721 eeiasfgeri kntfnwtvpf lsslaclila aatiilyfip lryiiliwgi nkftkklrnp
      781 ysidnnelld flsrvpsdvq kvqyaelklc sshsplrkkr sal
//
LOCUS       XP_047288797             878 aa            linear   PRI 05-AUG-2025
DEFINITION  multiple C2 and transmembrane domain-containing protein 2 isoform
            X5 [Homo sapiens].
ACCESSION   XP_047288797
VERSION     XP_047288797.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432841.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..878
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..878
                     /product="multiple C2 and transmembrane domain-containing
                     protein 2 isoform X5"
                     /calculated_mol_wt=99465
     Region          195..314
                     /region_name="C2A_MCTP_PRT"
                     /note="C2 domain first repeat found in Multiple C2 domain
                     and Transmembrane region Proteins (MCTP); cd04042"
                     /db_xref="CDD:176007"
     Site            order(210,216,263,265,270)
                     /site_type="other"
                     /note="putative Ca2+ binding site [ion binding]"
                     /db_xref="CDD:176007"
     Region          357..469
                     /region_name="C2B_MCTP_PRT"
                     /note="C2 domain second repeat found in Multiple C2 domain
                     and Transmembrane region Proteins (MCTP); cd08376"
                     /db_xref="CDD:176022"
     Site            order(375,422,424,430)
                     /site_type="other"
                     /note="putative Ca2+ binding site [ion binding]"
                     /db_xref="CDD:176022"
     Region          509..627
                     /region_name="C2C_MCTP_PRT"
                     /note="C2 domain third repeat found in Multiple C2 domain
                     and Transmembrane region Proteins (MCTP); cd08377"
                     /db_xref="CDD:176023"
     Site            order(525,531,577,579,585)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:176023"
     Region          <771..>824
                     /region_name="PRT_C"
                     /note="Plant phosphoribosyltransferase C-terminal;
                     pfam08372"
                     /db_xref="CDD:337028"
     CDS             1..878
                     /gene="MCTP2"
                     /coded_by="XM_047432841.1:214..2850"
                     /db_xref="GeneID:55784"
                     /db_xref="HGNC:HGNC:25636"
                     /db_xref="MIM:616297"
ORIGIN      
        1 mdldkpsvwg slkqrtrpll inlskkkvkk npskppdlra rhhldrrlsl svpdlleaea
       61 lapegrpysg pqssytsvps slstagifpk ssssslkqse eeldwsqeea shlhvvetds
      121 eeayaspaer rrvssngifd lqktslggda peepeklcgs sdlnasmtsq hfeeqsvpge
      181 asdglsnlps pfaylltihl kegrnlvvrd rcgtsdpyvk fklngktlyk skviyknlnp
      241 vwdeivvlpi qsldqklrvk vydrdlttsd fmgsafvils dlelnrtteh ilkledpnsl
      301 eddmgvivln lnlvvkqgdf krhrwsnrkr lsasksslir nlrlseslkk nqlwngiisi
      361 tllegknvsg gsmtemfvql klgdqryksk tlcksanpqw qeqfdfhyfs drmgildiev
      421 wgkdnkkhee rlgtckvdis alplkqancl elpldsclga llmlvtltpc agvsvsdlcv
      481 cpladlserk qitqryclqn slkdvkdvgi lqvkvlkaad llaadfsgks dpfcllelgn
      541 drlqthtvyk nlnpewnkvf tfpikdihdv levtvfdedg dkppdflgkv aipllsirdg
      601 qpncyvlknk dleqafkgvi ylemdliynp vkasirtftp rekrfvedsr klskkilsrd
      661 vdrvkritma iwntmqflks cfqwestlrs tiafavflit vwnfelymip lalllifvyn
      721 firpvkgkvs siqdsqestd iddeededdk esekkglier iymvqdivst vqnvleeias
      781 fgerikntfn wtvpflssla clilaaatii lyfiplryii liwginkftk klrnpysidn
      841 nelldflsrv psdvqkvqya elklcsshsp lrkkrsal
//
LOCUS       XP_011520076             695 aa            linear   PRI 05-AUG-2025
DEFINITION  multiple C2 and transmembrane domain-containing protein 2 isoform
            X2 [Homo sapiens].
ACCESSION   XP_011520076
VERSION     XP_011520076.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521774.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..695
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..695
                     /product="multiple C2 and transmembrane domain-containing
                     protein 2 isoform X2"
                     /calculated_mol_wt=78298
     Region          195..314
                     /region_name="C2A_MCTP_PRT"
                     /note="C2 domain first repeat found in Multiple C2 domain
                     and Transmembrane region Proteins (MCTP); cd04042"
                     /db_xref="CDD:176007"
     Site            order(210,216,263,265,270)
                     /site_type="other"
                     /note="putative Ca2+ binding site [ion binding]"
                     /db_xref="CDD:176007"
     Region          357..469
                     /region_name="C2B_MCTP_PRT"
                     /note="C2 domain second repeat found in Multiple C2 domain
                     and Transmembrane region Proteins (MCTP); cd08376"
                     /db_xref="CDD:176022"
     Site            order(375,422,424,430)
                     /site_type="other"
                     /note="putative Ca2+ binding site [ion binding]"
                     /db_xref="CDD:176022"
     Region          509..627
                     /region_name="C2C_MCTP_PRT"
                     /note="C2 domain third repeat found in Multiple C2 domain
                     and Transmembrane region Proteins (MCTP); cd08377"
                     /db_xref="CDD:176023"
     Site            order(525,531,577,579,585)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:176023"
     CDS             1..695
                     /gene="MCTP2"
                     /coded_by="XM_011521774.3:156..2243"
                     /db_xref="GeneID:55784"
                     /db_xref="HGNC:HGNC:25636"
                     /db_xref="MIM:616297"
ORIGIN      
        1 mdldkpsvwg slkqrtrpll inlskkkvkk npskppdlra rhhldrrlsl svpdlleaea
       61 lapegrpysg pqssytsvps slstagifpk ssssslkqse eeldwsqeea shlhvvetds
      121 eeayaspaer rrvssngifd lqktslggda peepeklcgs sdlnasmtsq hfeeqsvpge
      181 asdglsnlps pfaylltihl kegrnlvvrd rcgtsdpyvk fklngktlyk skviyknlnp
      241 vwdeivvlpi qsldqklrvk vydrdlttsd fmgsafvils dlelnrtteh ilkledpnsl
      301 eddmgvivln lnlvvkqgdf krhrwsnrkr lsasksslir nlrlseslkk nqlwngiisi
      361 tllegknvsg gsmtemfvql klgdqryksk tlcksanpqw qeqfdfhyfs drmgildiev
      421 wgkdnkkhee rlgtckvdis alplkqancl elpldsclga llmlvtltpc agvsvsdlcv
      481 cpladlserk qitqryclqn slkdvkdvgi lqvkvlkaad llaadfsgks dpfcllelgn
      541 drlqthtvyk nlnpewnkvf tfpikdihdv levtvfdedg dkppdflgkv aipllsirdg
      601 qpncyvlknk dleqafkgvi ylemdliynp vkasirtftp rekrfvedsr klskkilsrd
      661 vdrvkritma iwntmqflks cfqwestlrs tiafa
//
LOCUS       XP_047288798             695 aa            linear   PRI 05-AUG-2025
DEFINITION  multiple C2 and transmembrane domain-containing protein 2 isoform
            X2 [Homo sapiens].
ACCESSION   XP_047288798
VERSION     XP_047288798.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432842.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..695
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..695
                     /product="multiple C2 and transmembrane domain-containing
                     protein 2 isoform X2"
                     /calculated_mol_wt=78298
     Region          195..314
                     /region_name="C2A_MCTP_PRT"
                     /note="C2 domain first repeat found in Multiple C2 domain
                     and Transmembrane region Proteins (MCTP); cd04042"
                     /db_xref="CDD:176007"
     Site            order(210,216,263,265,270)
                     /site_type="other"
                     /note="putative Ca2+ binding site [ion binding]"
                     /db_xref="CDD:176007"
     Region          357..469
                     /region_name="C2B_MCTP_PRT"
                     /note="C2 domain second repeat found in Multiple C2 domain
                     and Transmembrane region Proteins (MCTP); cd08376"
                     /db_xref="CDD:176022"
     Site            order(375,422,424,430)
                     /site_type="other"
                     /note="putative Ca2+ binding site [ion binding]"
                     /db_xref="CDD:176022"
     Region          509..627
                     /region_name="C2C_MCTP_PRT"
                     /note="C2 domain third repeat found in Multiple C2 domain
                     and Transmembrane region Proteins (MCTP); cd08377"
                     /db_xref="CDD:176023"
     Site            order(525,531,577,579,585)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:176023"
     CDS             1..695
                     /gene="MCTP2"
                     /coded_by="XM_047432842.1:170..2257"
                     /db_xref="GeneID:55784"
                     /db_xref="HGNC:HGNC:25636"
                     /db_xref="MIM:616297"
ORIGIN      
        1 mdldkpsvwg slkqrtrpll inlskkkvkk npskppdlra rhhldrrlsl svpdlleaea
       61 lapegrpysg pqssytsvps slstagifpk ssssslkqse eeldwsqeea shlhvvetds
      121 eeayaspaer rrvssngifd lqktslggda peepeklcgs sdlnasmtsq hfeeqsvpge
      181 asdglsnlps pfaylltihl kegrnlvvrd rcgtsdpyvk fklngktlyk skviyknlnp
      241 vwdeivvlpi qsldqklrvk vydrdlttsd fmgsafvils dlelnrtteh ilkledpnsl
      301 eddmgvivln lnlvvkqgdf krhrwsnrkr lsasksslir nlrlseslkk nqlwngiisi
      361 tllegknvsg gsmtemfvql klgdqryksk tlcksanpqw qeqfdfhyfs drmgildiev
      421 wgkdnkkhee rlgtckvdis alplkqancl elpldsclga llmlvtltpc agvsvsdlcv
      481 cpladlserk qitqryclqn slkdvkdvgi lqvkvlkaad llaadfsgks dpfcllelgn
      541 drlqthtvyk nlnpewnkvf tfpikdihdv levtvfdedg dkppdflgkv aipllsirdg
      601 qpncyvlknk dleqafkgvi ylemdliynp vkasirtftp rekrfvedsr klskkilsrd
      661 vdrvkritma iwntmqflks cfqwestlrs tiafa
//
LOCUS       XP_047288799             529 aa            linear   PRI 05-AUG-2025
DEFINITION  multiple C2 and transmembrane domain-containing protein 2 isoform
            X3 [Homo sapiens].
ACCESSION   XP_047288799
VERSION     XP_047288799.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432843.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..529
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..529
                     /product="multiple C2 and transmembrane domain-containing
                     protein 2 isoform X3"
                     /calculated_mol_wt=60149
     Region          29..148
                     /region_name="C2A_MCTP_PRT"
                     /note="C2 domain first repeat found in Multiple C2 domain
                     and Transmembrane region Proteins (MCTP); cd04042"
                     /db_xref="CDD:176007"
     Site            order(44,50,97,99,104)
                     /site_type="other"
                     /note="putative Ca2+ binding site [ion binding]"
                     /db_xref="CDD:176007"
     Region          191..303
                     /region_name="C2B_MCTP_PRT"
                     /note="C2 domain second repeat found in Multiple C2 domain
                     and Transmembrane region Proteins (MCTP); cd08376"
                     /db_xref="CDD:176022"
     Site            order(209,256,258,264)
                     /site_type="other"
                     /note="putative Ca2+ binding site [ion binding]"
                     /db_xref="CDD:176022"
     Region          343..461
                     /region_name="C2C_MCTP_PRT"
                     /note="C2 domain third repeat found in Multiple C2 domain
                     and Transmembrane region Proteins (MCTP); cd08377"
                     /db_xref="CDD:176023"
     Site            order(359,365,411,413,419)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:176023"
     CDS             1..529
                     /gene="MCTP2"
                     /coded_by="XM_047432843.1:138..1727"
                     /db_xref="GeneID:55784"
                     /db_xref="HGNC:HGNC:25636"
                     /db_xref="MIM:616297"
ORIGIN      
        1 mtsqhfeeqs vpgeasdgls nlpspfayll tihlkegrnl vvrdrcgtsd pyvkfklngk
       61 tlykskviyk nlnpvwdeiv vlpiqsldqk lrvkvydrdl ttsdfmgsaf vilsdlelnr
      121 ttehilkled pnsleddmgv ivlnlnlvvk qgdfkrhrws nrkrlsasks slirnlrlse
      181 slkknqlwng iisitllegk nvsggsmtem fvqlklgdqr yksktlcksa npqwqeqfdf
      241 hyfsdrmgil dievwgkdnk kheerlgtck vdisalplkq anclelplds clgallmlvt
      301 ltpcagvsvs dlcvcpladl serkqitqry clqnslkdvk dvgilqvkvl kaadllaadf
      361 sgksdpfcll elgndrlqth tvyknlnpew nkvftfpikd ihdvlevtvf dedgdkppdf
      421 lgkvaiplls irdgqpncyv lknkdleqaf kgviylemdl iynpvkasir tftprekrfv
      481 edsrklskki lsrdvdrvkr itmaiwntmq flkscfqwes tlrstiafa
//
LOCUS       XP_005255017             466 aa            linear   PRI 05-AUG-2025
DEFINITION  multiple C2 and transmembrane domain-containing protein 2 isoform
            X4 [Homo sapiens].
ACCESSION   XP_005255017
VERSION     XP_005255017.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254960.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..466
                     /product="multiple C2 and transmembrane domain-containing
                     protein 2 isoform X4"
                     /calculated_mol_wt=53062
     Region          <1..57
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     Region          97..215
                     /region_name="C2C_MCTP_PRT"
                     /note="C2 domain third repeat found in Multiple C2 domain
                     and Transmembrane region Proteins (MCTP); cd08377"
                     /db_xref="CDD:176023"
     Site            order(113,119,165,167,173)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:176023"
     Region          <359..>412
                     /region_name="PRT_C"
                     /note="Plant phosphoribosyltransferase C-terminal;
                     pfam08372"
                     /db_xref="CDD:337028"
     CDS             1..466
                     /gene="MCTP2"
                     /coded_by="XM_005254960.2:374..1774"
                     /db_xref="GeneID:55784"
                     /db_xref="HGNC:HGNC:25636"
                     /db_xref="MIM:616297"
ORIGIN      
        1 mgildievwg kdnkkheerl gtckvdisal plkqanclel pldsclgall mlvtltpcag
       61 vsvsdlcvcp ladlserkqi tqryclqnsl kdvkdvgilq vkvlkaadll aadfsgksdp
      121 fcllelgndr lqthtvyknl npewnkvftf pikdihdvle vtvfdedgdk ppdflgkvai
      181 pllsirdgqp ncyvlknkdl eqafkgviyl emdliynpvk asirtftpre krfvedsrkl
      241 skkilsrdvd rvkritmaiw ntmqflkscf qwestlrsti afavflitvw nfelymipla
      301 lllifvynfi rpvkgkvssi qdsqestdid deededdkes ekkglieriy mvqdivstvq
      361 nvleeiasfg erikntfnwt vpflsslacl ilaaatiily fiplryiili wginkftkkl
      421 rnpysidnne lldflsrvps dvqkvqyael klcsshsplr kkrsal
//
LOCUS       XP_047288800             944 aa            linear   PRI 05-AUG-2025
DEFINITION  protein unc-45 homolog A isoform X1 [Homo sapiens].
ACCESSION   XP_047288800
VERSION     XP_047288800.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432844.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..944
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..944
                     /product="protein unc-45 homolog A isoform X1"
                     /calculated_mol_wt=102946
     Region          21..49
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(22,25..26,29..30,32,59,62..63,66..67,69..70,93,
                     96..97,100..101,104)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          <28..>125
                     /region_name="NlpI"
                     /note="Lipoprotein NlpI, contains TPR repeats [Cell
                     wall/membrane/envelope biogenesis]; COG4785"
                     /db_xref="CDD:443815"
     Region          57..87
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          92..120
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          363..505
                     /region_name="UNC45-central"
                     /note="Myosin-binding striated muscle assembly central;
                     pfam11701"
                     /db_xref="CDD:432011"
     Site            order(751,755,759,793,797,801,836,840)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293788"
     Region          768..803
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          806..842
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     CDS             1..944
                     /gene="UNC45A"
                     /gene_synonym="GC-UNC45; GCUNC-45; GCUNC45; IRO039700;
                     OOHE; SMAP-1; SMAP1; UNC-45A"
                     /coded_by="XM_047432844.1:836..3670"
                     /db_xref="GeneID:55898"
                     /db_xref="HGNC:HGNC:30594"
                     /db_xref="MIM:611219"
ORIGIN      
        1 mtvsgpgtpe prpatpgass veqlrkegne lfkcgdygga laaytqalgl datpqdqavl
       61 hrnraachlk ledydkaete askaiekdgg dvkalyrrsq aleklgrldq avldlqrcvs
      121 lepknkvfqe alrniggqiq ekvrymsstd akveqmfqil ldpeekgtek kqkasqnlvv
      181 laredagaek ifrsngvqll qrlldmgetd lmlaalrtlv gicsehqsrt vatlsilgtr
      241 rvvsilgves qavslaachl lqvmfdalke gvkkgfrgke gaiivdpare lkvlisnlld
      301 lltevgvsgq grdnaltlli kavprkslkd pnnsltlwvi dqglkkilev ggslqdppge
      361 lavtansrms asillsklfd dlkcdaeren fhrlcenyik swfegqglag klraiqtvsc
      421 llqgpcdagn ralelsgvme svialcaseq eeeqlvavea lihaagkakr asfitangvs
      481 llkdlykcse kdsiriralv glcklgsagg tdfsmkqfae gstlklakqc rkwlcndqid
      541 agtrrwaveg layltfdadv keefvedaaa lkalfqlsrl eersvlfava salvnctnsy
      601 dyeepdpkmv elakyakqhv peqhpkdkps fvrarvkkll aagvvsamvc mvktespvlt
      661 sscrellsrv flalveeved rgtvvaqggg raliplaleg tdvgqtkaaq alakltitsn
      721 pemtfpgeri yevvrplvsl lhlncsglqn fealmaltnl agiserlrqk ilkekavpmi
      781 egymfeehem irraatecmc nlamskevqd lfeaqgndrl kllvlysged dellqraaag
      841 glamltsmrp tlcsripqvt thwleilqal llssnqelqh rgavvvlnmv easreiastl
      901 mesemmeils vlakgdhspv traaaacldk aveygliqpn qdge
//
LOCUS       XP_016877896             506 aa            linear   PRI 05-AUG-2025
DEFINITION  protein unc-45 homolog A isoform X2 [Homo sapiens].
ACCESSION   XP_016877896
VERSION     XP_016877896.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022407.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..506
                     /product="protein unc-45 homolog A isoform X2"
                     /calculated_mol_wt=55337
     Region          <1..67
                     /region_name="UNC45-central"
                     /note="Myosin-binding striated muscle assembly central;
                     pfam11701"
                     /db_xref="CDD:432011"
     Site            order(313,317,321,355,359,363,398,402)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293788"
     Region          330..365
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          368..404
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     CDS             1..506
                     /gene="UNC45A"
                     /gene_synonym="GC-UNC45; GCUNC-45; GCUNC45; IRO039700;
                     OOHE; SMAP-1; SMAP1; UNC-45A"
                     /coded_by="XM_017022407.3:135..1655"
                     /db_xref="GeneID:55898"
                     /db_xref="HGNC:HGNC:30594"
                     /db_xref="MIM:611219"
ORIGIN      
        1 mesvialcas eqeeeqlvav ealihaagka krasfitang vsllkdlykc sekdsirira
       61 lvglcklgsa ggtdfsmkqf aegstlklak qcrkwlcndq idagtrrwav eglayltfda
      121 dvkeefveda aalkalfqls rleersvlfa vasalvnctn sydyeepdpk mvelakyakq
      181 hvpeqhpkdk psfvrarvkk llaagvvsam vcmvktespv ltsscrells rvflalveev
      241 edrgtvvaqg ggraliplal egtdvgqtka aqalakltit snpemtfpge riyevvrplv
      301 sllhlncsgl qnfealmalt nlagiserlr qkilkekavp miegymfeeh emirraatec
      361 mcnlamskev qdlfeaqgnd rlkllvlysg eddellqraa agglamltsm rptlcsripq
      421 vtthwleilq alllssnqel qhrgavvvln mveasreias tlmesemmei lsvlakgdhs
      481 pvtraaaacl dkaveygliq pnqdge
//
LOCUS       XP_011520083            1714 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-Vc isoform X1 [Homo sapiens].
ACCESSION   XP_011520083
VERSION     XP_011520083.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521781.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1714
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1714
                     /product="unconventional myosin-Vc isoform X1"
                     /calculated_mol_wt=199518
     Region          81..741
                     /region_name="MYSc_Myo5"
                     /note="class V myosin, motor domain; cd01380"
                     /db_xref="CDD:276831"
     Site            order(109..117,161..168,207..217,435..440)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276831"
     Site            109..117
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276831"
     Site            161..168
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276831"
     Site            207..217
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276831"
     Site            435..443
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276831"
     Site            order(464..475,478..487)
                     /site_type="active"
                     /note="relay loop [active]"
                     /db_xref="CDD:276831"
     Site            674..684
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276831"
     Site            order(695..705,726..741)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276831"
     Region          755..776
                     /region_name="IQ"
                     /note="Calmodulin-binding motif; smart00015"
                     /db_xref="CDD:197470"
     Region          <785..>1355
                     /region_name="CCDC158"
                     /note="Coiled-coil domain-containing protein 158;
                     pfam15921"
                     /db_xref="CDD:464943"
     Region          1341..1708
                     /region_name="Myo5c_CBD"
                     /note="Cargo binding domain of myosin 5C; cd15476"
                     /db_xref="CDD:271260"
     CDS             1..1714
                     /gene="MYO5C"
                     /coded_by="XM_011521781.4:169..5313"
                     /db_xref="GeneID:55930"
                     /db_xref="HGNC:HGNC:7604"
                     /db_xref="MIM:610022"
ORIGIN      
        1 mavaelytqy nrvwipdpee vwksaeiakd yrvgdkvlrl lledgteldy svnpeslppl
       61 rnpdilvgen dltalsylhe pavlhnlrir faeskliyty sgiilvamnp ykqlpiygda
      121 iihaysgqnm gdmdphifav aeeaykqmar nnrnqsiivs gesgagktvs aryamryfat
      181 vsksgsnahv edkvlasnpi teavgnaktt rndnssrfgk yteisfdeqn qiiganmsty
      241 lleksrvvfq senernyhif yqlcasaqqs efkhlklgsa eefnytrmgg ntviegvndr
      301 aemvetqktf tllgfkedfq mdvfkilaai lhlgnvqita vgnerssvse ddshlkvfce
      361 llglesgrva qwlcnrkivt ssetvvkpmt rpqavnarda lakkiyahlf dfiverinqa
      421 lqfsgkqhtf igvldiygfe tfdvnsfeqf cinyaneklq qqfnmhvfkl eqeeymkedi
      481 pwtlidfydn qpvidlieak mgilelldee cllphgtden wlqklynnfv nrnplfekpr
      541 msntsfviqh fadkveykce gfleknrdtv ydmlveilra skfhlcanff qenptppspf
      601 gsmitvksak qvikpnskhf rttvgskfrs slyllmetln attphyvrci kpndeklpfe
      661 fdskrivqql racgvletir isaqsypsrw tyiefysryg ilmtkqelsf sdkkevckvv
      721 lhrliqdsnq yqfgktkiff ragqvaylek lrldklrqsc vmvqkhmrgw lqrkkflrer
      781 raaliiqqyf rgqqtvslyq lirmatitmq aysrgflarr ryrkmleehk avilqkyara
      841 wlarrrfqsi rrfvlniqlt yrvqrlqkkl edqnkenhgl vekltslaal ragdvekiqk
      901 leaelekaat hrrnyeekgk ryrdaveekl aklqkhnsel etqkeqiqlk lqekteelke
      961 kmdnltkqlf ddvqkeerqr mlleksfelk tqdyekqiqs lkeeikalkd ekmqlqhlve
     1021 gehvtsdglk aevarlskqv ktisefekei ellqaqkidv ekhvqsqkre mrekmseitk
     1081 qllesydied vrsrlsvedl ehlnedgelw fayeglkkat rvleshfqsq kdcyekeiea
     1141 lnfkvvhlsq einhlqklfr eendinesir hevtrltsen mmipdfkqqi selekqkqdl
     1201 eirlneqaek mkgkleelsn qlhrsqeeeg tqrkaleaqn eihtkekekl idkiqemqea
     1261 sdhlkkqfet esevkcnfrq easrltlenr dleeeldmkd rvikklqdqv ktlsktigka
     1321 ndvhsssgpk eylgmlqykr edeakliqnl ildlkprgvv vnmipglpah ilfmcvryad
     1381 slndanmlks lmnstingik qvvkehledf emlsfwlsnt chflnclkqy sgeeefmkhn
     1441 spqqnkncln nfdlseyrqi lsdvairiyh qfiiimekni qpiivpgmle yeslqgisgl
     1501 kptgfrkrss siddtdgytm tsvlqqlsyf yttmcqngld pelvrqavkq lffligavtl
     1561 nslflrkdmc scrkgmqirc nisyleewlk dknlqnslak etleplsqaa wllqvkkttd
     1621 sdakeiyerc tslsavqiik ilnsytpidd fekrvtpsfv rkvqallnsr edssqlmldt
     1681 kylfqvtfpf tpsphalemi qipssfklgf lnrl
//
LOCUS       XP_016877897            1697 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-Vc isoform X2 [Homo sapiens].
ACCESSION   XP_016877897
VERSION     XP_016877897.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022408.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1697
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1697
                     /product="unconventional myosin-Vc isoform X2"
                     /calculated_mol_wt=197692
     Region          12..1279
                     /region_name="COG5022"
                     /note="Myosin heavy chain [General function prediction
                     only]"
                     /db_xref="CDD:227355"
     Region          81..696
                     /region_name="MYSc_Myo5"
                     /note="class V myosin, motor domain; cd01380"
                     /db_xref="CDD:276831"
     Site            order(109..117,161..168,207..217,435..440)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276831"
     Site            109..117
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276831"
     Site            161..168
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276831"
     Site            207..217
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276831"
     Site            435..443
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276831"
     Site            order(464..475,478..487)
                     /site_type="active"
                     /note="relay loop [active]"
                     /db_xref="CDD:276831"
     Site            629..639
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276831"
     Site            order(650..660,681..696)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276831"
     Region          1324..1691
                     /region_name="Myo5c_CBD"
                     /note="Cargo binding domain of myosin 5C; cd15476"
                     /db_xref="CDD:271260"
     CDS             1..1697
                     /gene="MYO5C"
                     /coded_by="XM_017022408.3:169..5262"
                     /db_xref="GeneID:55930"
                     /db_xref="HGNC:HGNC:7604"
                     /db_xref="MIM:610022"
ORIGIN      
        1 mavaelytqy nrvwipdpee vwksaeiakd yrvgdkvlrl lledgteldy svnpeslppl
       61 rnpdilvgen dltalsylhe pavlhnlrir faeskliyty sgiilvamnp ykqlpiygda
      121 iihaysgqnm gdmdphifav aeeaykqmar nnrnqsiivs gesgagktvs aryamryfat
      181 vsksgsnahv edkvlasnpi teavgnaktt rndnssrfgk yteisfdeqn qiiganmsty
      241 lleksrvvfq senernyhif yqlcasaqqs efkhlklgsa eefnytrmgg ntviegvndr
      301 aemvetqktf tllgfkedfq mdvfkilaai lhlgnvqita vgnerssvse ddshlkvfce
      361 llglesgrva qwlcnrkivt ssetvvkpmt rpqavnarda lakkiyahlf dfiverinqa
      421 lqfsgkqhtf igvldiygfe tfdvnsfeqf cinyaneklq qqfnmhvfkl eqeeymkedi
      481 pwtlidfydn qpvidlieak mgilelldee cllphgtden wlqklynnfv nrnplfekpr
      541 msntsfviqh fadkveykce gfleknrdtv ydmlveilra skfrsslyll metlnattph
      601 yvrcikpnde klpfefdskr ivqqlracgv letirisaqs ypsrwtyief ysrygilmtk
      661 qelsfsdkke vckvvlhrli qdsnqyqfgk tkiffragqv ayleklrldk lrqscvmvqk
      721 hmrgwlqrkk flrerraali iqqyfrgqqt vrkaitaval keawaaiiiq khcrgylvrs
      781 lyqlirmati tmqaysrgfl arrryrkmle ehkavilqky arawlarrrf qsirrfvlni
      841 qltyrvqrlq kkledqnken hglvekltsl aalragdvek iqkleaelek aathrrnyee
      901 kgkryrdave eklaklqkhn seletqkeqi qlklqektee lkekmdnltk qlfddvqkee
      961 rqrmlleksf elktqdyekq iqslkeeika lkdekmqlqh lvegehvtsd glkaevarls
     1021 kqvktisefe keiellqaqk idvekhvqsq kremrekmse itkqllesyd iedvrsrlsv
     1081 edlehlnedg elwfayeglk katrvleshf qsqkdcyeke iealnfkvvh lsqeinhlqk
     1141 lfreendine sirhevtrlt senmmipdfk qqiselekqk qdleirlneq aekmkgklee
     1201 lsnqlhrsqe eegtqrkale aqneihtkek eklidkiqem qeasdhlkkq fetesevkcn
     1261 frqeasrltl enrdleeeld mkdrvikklq dqvktlskti gkandvhsss gpkeylgmlq
     1321 ykredeakli qnlildlkpr gvvvnmipgl pahilfmcvr yadslndanm lkslmnstin
     1381 gikqvvkehl edfemlsfwl sntchflncl kqysgeeefm khnspqqnkn clnnfdlsey
     1441 rqilsdvair iyhqfiiime kniqpiivpg mleyeslqgi sglkptgfrk rsssiddtdg
     1501 ytmtsvlqql syfyttmcqn gldpelvrqa vkqlffliga vtlnslflrk dmcscrkgmq
     1561 ircnisylee wlkdknlqns laketlepls qaawllqvkk ttdsdakeiy erctslsavq
     1621 iikilnsytp iddfekrvtp sfvrkvqall nsredssqlm ldtkylfqvt fpftpsphal
     1681 emiqipssfk lgflnrl
//
LOCUS       XP_047288801            1669 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-Vc isoform X3 [Homo sapiens].
ACCESSION   XP_047288801
VERSION     XP_047288801.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432845.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1669
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1669
                     /product="unconventional myosin-Vc isoform X3"
                     /calculated_mol_wt=194531
     Region          12..1251
                     /region_name="COG5022"
                     /note="Myosin heavy chain [General function prediction
                     only]"
                     /db_xref="CDD:227355"
     Region          81..696
                     /region_name="MYSc_Myo5"
                     /note="class V myosin, motor domain; cd01380"
                     /db_xref="CDD:276831"
     Site            order(109..117,161..168,207..217,435..440)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276831"
     Site            109..117
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276831"
     Site            161..168
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276831"
     Site            207..217
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276831"
     Site            435..443
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276831"
     Site            order(464..475,478..487)
                     /site_type="active"
                     /note="relay loop [active]"
                     /db_xref="CDD:276831"
     Site            629..639
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276831"
     Site            order(650..660,681..696)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276831"
     Region          1296..1663
                     /region_name="Myo5c_CBD"
                     /note="Cargo binding domain of myosin 5C; cd15476"
                     /db_xref="CDD:271260"
     CDS             1..1669
                     /gene="MYO5C"
                     /coded_by="XM_047432845.1:169..5178"
                     /db_xref="GeneID:55930"
                     /db_xref="HGNC:HGNC:7604"
                     /db_xref="MIM:610022"
ORIGIN      
        1 mavaelytqy nrvwipdpee vwksaeiakd yrvgdkvlrl lledgteldy svnpeslppl
       61 rnpdilvgen dltalsylhe pavlhnlrir faeskliyty sgiilvamnp ykqlpiygda
      121 iihaysgqnm gdmdphifav aeeaykqmar nnrnqsiivs gesgagktvs aryamryfat
      181 vsksgsnahv edkvlasnpi teavgnaktt rndnssrfgk yteisfdeqn qiiganmsty
      241 lleksrvvfq senernyhif yqlcasaqqs efkhlklgsa eefnytrmgg ntviegvndr
      301 aemvetqktf tllgfkedfq mdvfkilaai lhlgnvqita vgnerssvse ddshlkvfce
      361 llglesgrva qwlcnrkivt ssetvvkpmt rpqavnarda lakkiyahlf dfiverinqa
      421 lqfsgkqhtf igvldiygfe tfdvnsfeqf cinyaneklq qqfnmhvfkl eqeeymkedi
      481 pwtlidfydn qpvidlieak mgilelldee cllphgtden wlqklynnfv nrnplfekpr
      541 msntsfviqh fadkveykce gfleknrdtv ydmlveilra skfrsslyll metlnattph
      601 yvrcikpnde klpfefdskr ivqqlracgv letirisaqs ypsrwtyief ysrygilmtk
      661 qelsfsdkke vckvvlhrli qdsnqyqfgk tkiffragqv ayleklrldk lrqscvmvqk
      721 hmrgwlqrkk flrerraali iqqyfrgqqt vslyqlirma titmqaysrg flarrryrkm
      781 leehkavilq kyarawlarr rfqsirrfvl niqltyrvqr lqkkledqnk enhglveklt
      841 slaalragdv ekiqkleael ekaathrrny eekgkryrda veeklaklqk hnseletqke
      901 qiqlklqekt eelkekmdnl tkqlfddvqk eerqrmllek sfelktqdye kqiqslkeei
      961 kalkdekmql qhlvegehvt sdglkaevar lskqvktise fekeiellqa qkidvekhvq
     1021 sqkremrekm seitkqlles ydiedvrsrl svedlehlne dgelwfayeg lkkatrvles
     1081 hfqsqkdcye keiealnfkv vhlsqeinhl qklfreendi nesirhevtr ltsenmmipd
     1141 fkqqiselek qkqdleirln eqaekmkgkl eelsnqlhrs qeeegtqrka leaqneihtk
     1201 ekeklidkiq emqeasdhlk kqfetesevk cnfrqeasrl tlenrdleee ldmkdrvikk
     1261 lqdqvktlsk tigkandvhs ssgpkeylgm lqykredeak liqnlildlk prgvvvnmip
     1321 glpahilfmc vryadslnda nmlkslmnst ingikqvvke hledfemlsf wlsntchfln
     1381 clkqysgeee fmkhnspqqn knclnnfdls eyrqilsdva iriyhqfiii mekniqpiiv
     1441 pgmleyeslq gisglkptgf rkrsssiddt dgytmtsvlq qlsyfyttmc qngldpelvr
     1501 qavkqlffli gavtlnslfl rkdmcscrkg mqircnisyl eewlkdknlq nslaketlep
     1561 lsqaawllqv kkttdsdake iyerctslsa vqiikilnsy tpiddfekrv tpsfvrkvqa
     1621 llnsredssq lmldtkylfq vtfpftpsph alemiqipss fklgflnrl
//
LOCUS       XP_047288802            1455 aa            linear   PRI 05-AUG-2025
DEFINITION  unconventional myosin-Vc isoform X4 [Homo sapiens].
ACCESSION   XP_047288802
VERSION     XP_047288802.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432846.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1455
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1455
                     /product="unconventional myosin-Vc isoform X4"
                     /calculated_mol_wt=170271
     Region          <1..454
                     /region_name="Motor_domain"
                     /note="Myosin and Kinesin motor domain; cl22853"
                     /db_xref="CDD:473979"
     Region          2..1037
                     /region_name="COG5022"
                     /note="Myosin heavy chain [General function prediction
                     only]"
                     /db_xref="CDD:227355"
     Region          1082..1449
                     /region_name="Myo5c_CBD"
                     /note="Cargo binding domain of myosin 5C; cd15476"
                     /db_xref="CDD:271260"
     CDS             1..1455
                     /gene="MYO5C"
                     /coded_by="XM_047432846.1:119..4486"
                     /db_xref="GeneID:55930"
                     /db_xref="HGNC:HGNC:7604"
                     /db_xref="MIM:610022"
ORIGIN      
        1 mggntviegv ndraemvetq ktftllgfke dfqmdvfkil aailhlgnvq itavgnerss
       61 vseddshlkv fcellglesg rvaqwlcnrk ivtssetvvk pmtrpqavna rdalakkiya
      121 hlfdfiveri nqalqfsgkq htfigvldiy gfetfdvnsf eqfcinyane klqqqfnmhv
      181 fkleqeeymk edipwtlidf ydnqpvidli eakmgilell deecllphgt denwlqklyn
      241 nfvnrnplfe kprmsntsfv iqhfadkvey kcegfleknr dtvydmlvei lraskfhlca
      301 nffqenptpp spfgsmitvk sakqvikpns khfrttvgsk frsslyllme tlnattphyv
      361 rcikpndekl pfefdskriv qqlracgvle tirisaqsyp srwtyiefys rygilmtkqe
      421 lsfsdkkevc kvvlhrliqd snqyqfgktk iffragqvay leklrldklr qscvmvqkhm
      481 rgwlqrkkfl rerraaliiq qyfrgqqtvr kaitavalke awaaiiiqkh crgylvrsly
      541 qlirmatitm qaysrgflar rryrkmleeh kavilqkyar awlarrrfqs irrfvlniql
      601 tyrvqrlqkk ledqnkenhg lvekltslaa lragdvekiq kleaelekaa thrrnyeekg
      661 kryrdaveek laklqkhnse letqkeqiql klqekteelk ekmdnltkql fddvqkeerq
      721 rmlleksfel ktqdyekqiq slkeeikalk dekmqlqhlv egehvtsdgl kaevarlskq
      781 vktisefeke iellqaqkid vekhvqsqkr emrekmseit kqllesydie dvrsrlsved
      841 lehlnedgel wfayeglkka trvleshfqs qkdcyekeie alnfkvvhls qeinhlqklf
      901 reendinesi rhevtrltse nmmipdfkqq iselekqkqd leirlneqae kmkgkleels
      961 nqlhrsqeee gtqrkaleaq neihtkekek lidkiqemqe asdhlkkqfe tesevkcnfr
     1021 qeasrltlen rdleeeldmk drvikklqdq vktlsktigk andvhsssgp keylgmlqyk
     1081 redeakliqn lildlkprgv vvnmipglpa hilfmcvrya dslndanmlk slmnstingi
     1141 kqvvkehled femlsfwlsn tchflnclkq ysgeeefmkh nspqqnkncl nnfdlseyrq
     1201 ilsdvairiy hqfiiimekn iqpiivpgml eyeslqgisg lkptgfrkrs ssiddtdgyt
     1261 mtsvlqqlsy fyttmcqngl dpelvrqavk qlffligavt lnslflrkdm cscrkgmqir
     1321 cnisyleewl kdknlqnsla ketleplsqa awllqvkktt dsdakeiyer ctslsavqii
     1381 kilnsytpid dfekrvtpsf vrkvqallns redssqlmld tkylfqvtfp ftpsphalem
     1441 iqipssfklg flnrl
//
LOCUS       XP_005254594             721 aa            linear   PRI 05-AUG-2025
DEFINITION  mitogen-activated protein kinase 6 isoform X1 [Homo sapiens].
ACCESSION   XP_005254594
VERSION     XP_005254594.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254537.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..721
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..721
                     /product="mitogen-activated protein kinase 6 isoform X1"
                     /calculated_mol_wt=82550
     Region          14..355
                     /region_name="STKc_MAPK4_6"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     Mitogen-Activated Protein Kinases 4 (also called ERK4) and
                     6 (also called ERK3); cd07854"
                     /db_xref="CDD:143359"
     Site            order(26..29,31..32,34,47,49,64,78,108..111,114,116..117,
                     152,154,156..157,159,170..171,174,189,191..194,196,234)
                     /site_type="active"
                     /db_xref="CDD:143359"
     Site            order(26..29,31..32,34,47,49,78,108..111,114,117,154,
                     156..157,159,170..171)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:143359"
     Site            order(64,116,152,154,174,189,191..194,196,234)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:143359"
     Site            order(75,112..113,118,128,131,138,160..163,165,319,321,
                     324)
                     /site_type="other"
                     /note="KIM docking site [polypeptide binding]"
                     /db_xref="CDD:143359"
     Site            170..196
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:143359"
     CDS             1..721
                     /gene="MAPK6"
                     /gene_synonym="ERK3; HsT17250; p97MAPK; PRKM6"
                     /coded_by="XM_005254537.4:1446..3611"
                     /db_xref="GeneID:5597"
                     /db_xref="HGNC:HGNC:6879"
                     /db_xref="MIM:602904"
ORIGIN      
        1 maekfeslmn ihgfdlgsry mdlkplgcgg nglvfsavdn dcdkrvaikk ivltdpqsvk
       61 halreikiir rldhdnivkv feilgpsgsq ltddvgslte lnsvyivqey metdlanvle
      121 qgplleehar lfmyqllrgl kyihsanvlh rdlkpanlfi ntedlvlkig dfglarimdp
      181 hyshkghlse glvtkwyrsp rlllspnnyt kaidmwaagc ifaemltgkt lfagaheleq
      241 mqlilesipv vheedrqell svipvyirnd mtephkpltq llpgisreal dfleqiltfs
      301 pmdrltaeea lshpymsiys fpmdepissh pfhiedevdd illmdethsh iynweryhdc
      361 qfsehdwpvh nnfdidevql dpralsdvtd eeevqvdprk yldgdrekyl edpafdtnys
      421 tepcwqysdh henkycdlec shtcnyktrs ssyldnlvwr esevnhyyep kliidlsnwk
      481 eqskeksdkk gkskcerngl vkaqialeea sqqlagkere knqgfdfdsf iagtiqlssq
      541 heptdvvdkl ndlnssvsql elkslisksv sqekqekgma nlaqlealyq sswdsqfvsg
      601 gedcffinqf cevrkdeqve kentytsyld kffsrkedte mletepvedg klgergheeg
      661 flnnsgeflf nkqlesigip qfhspvgspl ksiqatltps amksspqiph qtyssilkhl
      721 n
//
LOCUS       XP_011520084             721 aa            linear   PRI 05-AUG-2025
DEFINITION  mitogen-activated protein kinase 6 isoform X1 [Homo sapiens].
ACCESSION   XP_011520084
VERSION     XP_011520084.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521782.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..721
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..721
                     /product="mitogen-activated protein kinase 6 isoform X1"
                     /calculated_mol_wt=82550
     Region          14..355
                     /region_name="STKc_MAPK4_6"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     Mitogen-Activated Protein Kinases 4 (also called ERK4) and
                     6 (also called ERK3); cd07854"
                     /db_xref="CDD:143359"
     Site            order(26..29,31..32,34,47,49,64,78,108..111,114,116..117,
                     152,154,156..157,159,170..171,174,189,191..194,196,234)
                     /site_type="active"
                     /db_xref="CDD:143359"
     Site            order(26..29,31..32,34,47,49,78,108..111,114,117,154,
                     156..157,159,170..171)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:143359"
     Site            order(64,116,152,154,174,189,191..194,196,234)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:143359"
     Site            order(75,112..113,118,128,131,138,160..163,165,319,321,
                     324)
                     /site_type="other"
                     /note="KIM docking site [polypeptide binding]"
                     /db_xref="CDD:143359"
     Site            170..196
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:143359"
     CDS             1..721
                     /gene="MAPK6"
                     /gene_synonym="ERK3; HsT17250; p97MAPK; PRKM6"
                     /coded_by="XM_011521782.2:870..3035"
                     /db_xref="GeneID:5597"
                     /db_xref="HGNC:HGNC:6879"
                     /db_xref="MIM:602904"
ORIGIN      
        1 maekfeslmn ihgfdlgsry mdlkplgcgg nglvfsavdn dcdkrvaikk ivltdpqsvk
       61 halreikiir rldhdnivkv feilgpsgsq ltddvgslte lnsvyivqey metdlanvle
      121 qgplleehar lfmyqllrgl kyihsanvlh rdlkpanlfi ntedlvlkig dfglarimdp
      181 hyshkghlse glvtkwyrsp rlllspnnyt kaidmwaagc ifaemltgkt lfagaheleq
      241 mqlilesipv vheedrqell svipvyirnd mtephkpltq llpgisreal dfleqiltfs
      301 pmdrltaeea lshpymsiys fpmdepissh pfhiedevdd illmdethsh iynweryhdc
      361 qfsehdwpvh nnfdidevql dpralsdvtd eeevqvdprk yldgdrekyl edpafdtnys
      421 tepcwqysdh henkycdlec shtcnyktrs ssyldnlvwr esevnhyyep kliidlsnwk
      481 eqskeksdkk gkskcerngl vkaqialeea sqqlagkere knqgfdfdsf iagtiqlssq
      541 heptdvvdkl ndlnssvsql elkslisksv sqekqekgma nlaqlealyq sswdsqfvsg
      601 gedcffinqf cevrkdeqve kentytsyld kffsrkedte mletepvedg klgergheeg
      661 flnnsgeflf nkqlesigip qfhspvgspl ksiqatltps amksspqiph qtyssilkhl
      721 n
//
LOCUS       XP_005254595             721 aa            linear   PRI 05-AUG-2025
DEFINITION  mitogen-activated protein kinase 6 isoform X1 [Homo sapiens].
ACCESSION   XP_005254595
VERSION     XP_005254595.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254538.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..721
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..721
                     /product="mitogen-activated protein kinase 6 isoform X1"
                     /calculated_mol_wt=82550
     Region          14..355
                     /region_name="STKc_MAPK4_6"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     Mitogen-Activated Protein Kinases 4 (also called ERK4) and
                     6 (also called ERK3); cd07854"
                     /db_xref="CDD:143359"
     Site            order(26..29,31..32,34,47,49,64,78,108..111,114,116..117,
                     152,154,156..157,159,170..171,174,189,191..194,196,234)
                     /site_type="active"
                     /db_xref="CDD:143359"
     Site            order(26..29,31..32,34,47,49,78,108..111,114,117,154,
                     156..157,159,170..171)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:143359"
     Site            order(64,116,152,154,174,189,191..194,196,234)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:143359"
     Site            order(75,112..113,118,128,131,138,160..163,165,319,321,
                     324)
                     /site_type="other"
                     /note="KIM docking site [polypeptide binding]"
                     /db_xref="CDD:143359"
     Site            170..196
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:143359"
     CDS             1..721
                     /gene="MAPK6"
                     /gene_synonym="ERK3; HsT17250; p97MAPK; PRKM6"
                     /coded_by="XM_005254538.3:804..2969"
                     /db_xref="GeneID:5597"
                     /db_xref="HGNC:HGNC:6879"
                     /db_xref="MIM:602904"
ORIGIN      
        1 maekfeslmn ihgfdlgsry mdlkplgcgg nglvfsavdn dcdkrvaikk ivltdpqsvk
       61 halreikiir rldhdnivkv feilgpsgsq ltddvgslte lnsvyivqey metdlanvle
      121 qgplleehar lfmyqllrgl kyihsanvlh rdlkpanlfi ntedlvlkig dfglarimdp
      181 hyshkghlse glvtkwyrsp rlllspnnyt kaidmwaagc ifaemltgkt lfagaheleq
      241 mqlilesipv vheedrqell svipvyirnd mtephkpltq llpgisreal dfleqiltfs
      301 pmdrltaeea lshpymsiys fpmdepissh pfhiedevdd illmdethsh iynweryhdc
      361 qfsehdwpvh nnfdidevql dpralsdvtd eeevqvdprk yldgdrekyl edpafdtnys
      421 tepcwqysdh henkycdlec shtcnyktrs ssyldnlvwr esevnhyyep kliidlsnwk
      481 eqskeksdkk gkskcerngl vkaqialeea sqqlagkere knqgfdfdsf iagtiqlssq
      541 heptdvvdkl ndlnssvsql elkslisksv sqekqekgma nlaqlealyq sswdsqfvsg
      601 gedcffinqf cevrkdeqve kentytsyld kffsrkedte mletepvedg klgergheeg
      661 flnnsgeflf nkqlesigip qfhspvgspl ksiqatltps amksspqiph qtyssilkhl
      721 n
//
LOCUS       XP_047288803             721 aa            linear   PRI 05-AUG-2025
DEFINITION  mitogen-activated protein kinase 6 isoform X1 [Homo sapiens].
ACCESSION   XP_047288803
VERSION     XP_047288803.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432847.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..721
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..721
                     /product="mitogen-activated protein kinase 6 isoform X1"
                     /calculated_mol_wt=82550
     Region          14..355
                     /region_name="STKc_MAPK4_6"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     Mitogen-Activated Protein Kinases 4 (also called ERK4) and
                     6 (also called ERK3); cd07854"
                     /db_xref="CDD:143359"
     Site            order(26..29,31..32,34,47,49,64,78,108..111,114,116..117,
                     152,154,156..157,159,170..171,174,189,191..194,196,234)
                     /site_type="active"
                     /db_xref="CDD:143359"
     Site            order(26..29,31..32,34,47,49,78,108..111,114,117,154,
                     156..157,159,170..171)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:143359"
     Site            order(64,116,152,154,174,189,191..194,196,234)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:143359"
     Site            order(75,112..113,118,128,131,138,160..163,165,319,321,
                     324)
                     /site_type="other"
                     /note="KIM docking site [polypeptide binding]"
                     /db_xref="CDD:143359"
     Site            170..196
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:143359"
     CDS             1..721
                     /gene="MAPK6"
                     /gene_synonym="ERK3; HsT17250; p97MAPK; PRKM6"
                     /coded_by="XM_047432847.1:1039..3204"
                     /db_xref="GeneID:5597"
                     /db_xref="HGNC:HGNC:6879"
                     /db_xref="MIM:602904"
ORIGIN      
        1 maekfeslmn ihgfdlgsry mdlkplgcgg nglvfsavdn dcdkrvaikk ivltdpqsvk
       61 halreikiir rldhdnivkv feilgpsgsq ltddvgslte lnsvyivqey metdlanvle
      121 qgplleehar lfmyqllrgl kyihsanvlh rdlkpanlfi ntedlvlkig dfglarimdp
      181 hyshkghlse glvtkwyrsp rlllspnnyt kaidmwaagc ifaemltgkt lfagaheleq
      241 mqlilesipv vheedrqell svipvyirnd mtephkpltq llpgisreal dfleqiltfs
      301 pmdrltaeea lshpymsiys fpmdepissh pfhiedevdd illmdethsh iynweryhdc
      361 qfsehdwpvh nnfdidevql dpralsdvtd eeevqvdprk yldgdrekyl edpafdtnys
      421 tepcwqysdh henkycdlec shtcnyktrs ssyldnlvwr esevnhyyep kliidlsnwk
      481 eqskeksdkk gkskcerngl vkaqialeea sqqlagkere knqgfdfdsf iagtiqlssq
      541 heptdvvdkl ndlnssvsql elkslisksv sqekqekgma nlaqlealyq sswdsqfvsg
      601 gedcffinqf cevrkdeqve kentytsyld kffsrkedte mletepvedg klgergheeg
      661 flnnsgeflf nkqlesigip qfhspvgspl ksiqatltps amksspqiph qtyssilkhl
      721 n
//
LOCUS       XP_047288804             721 aa            linear   PRI 05-AUG-2025
DEFINITION  mitogen-activated protein kinase 6 isoform X1 [Homo sapiens].
ACCESSION   XP_047288804
VERSION     XP_047288804.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432848.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..721
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..721
                     /product="mitogen-activated protein kinase 6 isoform X1"
                     /calculated_mol_wt=82550
     Region          14..355
                     /region_name="STKc_MAPK4_6"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     Mitogen-Activated Protein Kinases 4 (also called ERK4) and
                     6 (also called ERK3); cd07854"
                     /db_xref="CDD:143359"
     Site            order(26..29,31..32,34,47,49,64,78,108..111,114,116..117,
                     152,154,156..157,159,170..171,174,189,191..194,196,234)
                     /site_type="active"
                     /db_xref="CDD:143359"
     Site            order(26..29,31..32,34,47,49,78,108..111,114,117,154,
                     156..157,159,170..171)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:143359"
     Site            order(64,116,152,154,174,189,191..194,196,234)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:143359"
     Site            order(75,112..113,118,128,131,138,160..163,165,319,321,
                     324)
                     /site_type="other"
                     /note="KIM docking site [polypeptide binding]"
                     /db_xref="CDD:143359"
     Site            170..196
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:143359"
     CDS             1..721
                     /gene="MAPK6"
                     /gene_synonym="ERK3; HsT17250; p97MAPK; PRKM6"
                     /coded_by="XM_047432848.1:1000..3165"
                     /db_xref="GeneID:5597"
                     /db_xref="HGNC:HGNC:6879"
                     /db_xref="MIM:602904"
ORIGIN      
        1 maekfeslmn ihgfdlgsry mdlkplgcgg nglvfsavdn dcdkrvaikk ivltdpqsvk
       61 halreikiir rldhdnivkv feilgpsgsq ltddvgslte lnsvyivqey metdlanvle
      121 qgplleehar lfmyqllrgl kyihsanvlh rdlkpanlfi ntedlvlkig dfglarimdp
      181 hyshkghlse glvtkwyrsp rlllspnnyt kaidmwaagc ifaemltgkt lfagaheleq
      241 mqlilesipv vheedrqell svipvyirnd mtephkpltq llpgisreal dfleqiltfs
      301 pmdrltaeea lshpymsiys fpmdepissh pfhiedevdd illmdethsh iynweryhdc
      361 qfsehdwpvh nnfdidevql dpralsdvtd eeevqvdprk yldgdrekyl edpafdtnys
      421 tepcwqysdh henkycdlec shtcnyktrs ssyldnlvwr esevnhyyep kliidlsnwk
      481 eqskeksdkk gkskcerngl vkaqialeea sqqlagkere knqgfdfdsf iagtiqlssq
      541 heptdvvdkl ndlnssvsql elkslisksv sqekqekgma nlaqlealyq sswdsqfvsg
      601 gedcffinqf cevrkdeqve kentytsyld kffsrkedte mletepvedg klgergheeg
      661 flnnsgeflf nkqlesigip qfhspvgspl ksiqatltps amksspqiph qtyssilkhl
      721 n
//
LOCUS       XP_047288805             721 aa            linear   PRI 05-AUG-2025
DEFINITION  mitogen-activated protein kinase 6 isoform X1 [Homo sapiens].
ACCESSION   XP_047288805
VERSION     XP_047288805.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432849.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..721
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..721
                     /product="mitogen-activated protein kinase 6 isoform X1"
                     /calculated_mol_wt=82550
     Region          14..355
                     /region_name="STKc_MAPK4_6"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     Mitogen-Activated Protein Kinases 4 (also called ERK4) and
                     6 (also called ERK3); cd07854"
                     /db_xref="CDD:143359"
     Site            order(26..29,31..32,34,47,49,64,78,108..111,114,116..117,
                     152,154,156..157,159,170..171,174,189,191..194,196,234)
                     /site_type="active"
                     /db_xref="CDD:143359"
     Site            order(26..29,31..32,34,47,49,78,108..111,114,117,154,
                     156..157,159,170..171)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:143359"
     Site            order(64,116,152,154,174,189,191..194,196,234)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:143359"
     Site            order(75,112..113,118,128,131,138,160..163,165,319,321,
                     324)
                     /site_type="other"
                     /note="KIM docking site [polypeptide binding]"
                     /db_xref="CDD:143359"
     Site            170..196
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:143359"
     CDS             1..721
                     /gene="MAPK6"
                     /gene_synonym="ERK3; HsT17250; p97MAPK; PRKM6"
                     /coded_by="XM_047432849.1:804..2969"
                     /db_xref="GeneID:5597"
                     /db_xref="HGNC:HGNC:6879"
                     /db_xref="MIM:602904"
ORIGIN      
        1 maekfeslmn ihgfdlgsry mdlkplgcgg nglvfsavdn dcdkrvaikk ivltdpqsvk
       61 halreikiir rldhdnivkv feilgpsgsq ltddvgslte lnsvyivqey metdlanvle
      121 qgplleehar lfmyqllrgl kyihsanvlh rdlkpanlfi ntedlvlkig dfglarimdp
      181 hyshkghlse glvtkwyrsp rlllspnnyt kaidmwaagc ifaemltgkt lfagaheleq
      241 mqlilesipv vheedrqell svipvyirnd mtephkpltq llpgisreal dfleqiltfs
      301 pmdrltaeea lshpymsiys fpmdepissh pfhiedevdd illmdethsh iynweryhdc
      361 qfsehdwpvh nnfdidevql dpralsdvtd eeevqvdprk yldgdrekyl edpafdtnys
      421 tepcwqysdh henkycdlec shtcnyktrs ssyldnlvwr esevnhyyep kliidlsnwk
      481 eqskeksdkk gkskcerngl vkaqialeea sqqlagkere knqgfdfdsf iagtiqlssq
      541 heptdvvdkl ndlnssvsql elkslisksv sqekqekgma nlaqlealyq sswdsqfvsg
      601 gedcffinqf cevrkdeqve kentytsyld kffsrkedte mletepvedg klgergheeg
      661 flnnsgeflf nkqlesigip qfhspvgspl ksiqatltps amksspqiph qtyssilkhl
      721 n
//
LOCUS       XP_047288806             721 aa            linear   PRI 05-AUG-2025
DEFINITION  mitogen-activated protein kinase 6 isoform X1 [Homo sapiens].
ACCESSION   XP_047288806
VERSION     XP_047288806.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432850.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..721
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..721
                     /product="mitogen-activated protein kinase 6 isoform X1"
                     /calculated_mol_wt=82550
     Region          14..355
                     /region_name="STKc_MAPK4_6"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     Mitogen-Activated Protein Kinases 4 (also called ERK4) and
                     6 (also called ERK3); cd07854"
                     /db_xref="CDD:143359"
     Site            order(26..29,31..32,34,47,49,64,78,108..111,114,116..117,
                     152,154,156..157,159,170..171,174,189,191..194,196,234)
                     /site_type="active"
                     /db_xref="CDD:143359"
     Site            order(26..29,31..32,34,47,49,78,108..111,114,117,154,
                     156..157,159,170..171)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:143359"
     Site            order(64,116,152,154,174,189,191..194,196,234)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:143359"
     Site            order(75,112..113,118,128,131,138,160..163,165,319,321,
                     324)
                     /site_type="other"
                     /note="KIM docking site [polypeptide binding]"
                     /db_xref="CDD:143359"
     Site            170..196
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:143359"
     CDS             1..721
                     /gene="MAPK6"
                     /gene_synonym="ERK3; HsT17250; p97MAPK; PRKM6"
                     /coded_by="XM_047432850.1:959..3124"
                     /db_xref="GeneID:5597"
                     /db_xref="HGNC:HGNC:6879"
                     /db_xref="MIM:602904"
ORIGIN      
        1 maekfeslmn ihgfdlgsry mdlkplgcgg nglvfsavdn dcdkrvaikk ivltdpqsvk
       61 halreikiir rldhdnivkv feilgpsgsq ltddvgslte lnsvyivqey metdlanvle
      121 qgplleehar lfmyqllrgl kyihsanvlh rdlkpanlfi ntedlvlkig dfglarimdp
      181 hyshkghlse glvtkwyrsp rlllspnnyt kaidmwaagc ifaemltgkt lfagaheleq
      241 mqlilesipv vheedrqell svipvyirnd mtephkpltq llpgisreal dfleqiltfs
      301 pmdrltaeea lshpymsiys fpmdepissh pfhiedevdd illmdethsh iynweryhdc
      361 qfsehdwpvh nnfdidevql dpralsdvtd eeevqvdprk yldgdrekyl edpafdtnys
      421 tepcwqysdh henkycdlec shtcnyktrs ssyldnlvwr esevnhyyep kliidlsnwk
      481 eqskeksdkk gkskcerngl vkaqialeea sqqlagkere knqgfdfdsf iagtiqlssq
      541 heptdvvdkl ndlnssvsql elkslisksv sqekqekgma nlaqlealyq sswdsqfvsg
      601 gedcffinqf cevrkdeqve kentytsyld kffsrkedte mletepvedg klgergheeg
      661 flnnsgeflf nkqlesigip qfhspvgspl ksiqatltps amksspqiph qtyssilkhl
      721 n
//
LOCUS       XP_047288807             721 aa            linear   PRI 05-AUG-2025
DEFINITION  mitogen-activated protein kinase 6 isoform X1 [Homo sapiens].
ACCESSION   XP_047288807
VERSION     XP_047288807.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432851.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..721
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..721
                     /product="mitogen-activated protein kinase 6 isoform X1"
                     /calculated_mol_wt=82550
     Region          14..355
                     /region_name="STKc_MAPK4_6"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     Mitogen-Activated Protein Kinases 4 (also called ERK4) and
                     6 (also called ERK3); cd07854"
                     /db_xref="CDD:143359"
     Site            order(26..29,31..32,34,47,49,64,78,108..111,114,116..117,
                     152,154,156..157,159,170..171,174,189,191..194,196,234)
                     /site_type="active"
                     /db_xref="CDD:143359"
     Site            order(26..29,31..32,34,47,49,78,108..111,114,117,154,
                     156..157,159,170..171)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:143359"
     Site            order(64,116,152,154,174,189,191..194,196,234)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:143359"
     Site            order(75,112..113,118,128,131,138,160..163,165,319,321,
                     324)
                     /site_type="other"
                     /note="KIM docking site [polypeptide binding]"
                     /db_xref="CDD:143359"
     Site            170..196
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:143359"
     CDS             1..721
                     /gene="MAPK6"
                     /gene_synonym="ERK3; HsT17250; p97MAPK; PRKM6"
                     /coded_by="XM_047432851.1:2256..4421"
                     /db_xref="GeneID:5597"
                     /db_xref="HGNC:HGNC:6879"
                     /db_xref="MIM:602904"
ORIGIN      
        1 maekfeslmn ihgfdlgsry mdlkplgcgg nglvfsavdn dcdkrvaikk ivltdpqsvk
       61 halreikiir rldhdnivkv feilgpsgsq ltddvgslte lnsvyivqey metdlanvle
      121 qgplleehar lfmyqllrgl kyihsanvlh rdlkpanlfi ntedlvlkig dfglarimdp
      181 hyshkghlse glvtkwyrsp rlllspnnyt kaidmwaagc ifaemltgkt lfagaheleq
      241 mqlilesipv vheedrqell svipvyirnd mtephkpltq llpgisreal dfleqiltfs
      301 pmdrltaeea lshpymsiys fpmdepissh pfhiedevdd illmdethsh iynweryhdc
      361 qfsehdwpvh nnfdidevql dpralsdvtd eeevqvdprk yldgdrekyl edpafdtnys
      421 tepcwqysdh henkycdlec shtcnyktrs ssyldnlvwr esevnhyyep kliidlsnwk
      481 eqskeksdkk gkskcerngl vkaqialeea sqqlagkere knqgfdfdsf iagtiqlssq
      541 heptdvvdkl ndlnssvsql elkslisksv sqekqekgma nlaqlealyq sswdsqfvsg
      601 gedcffinqf cevrkdeqve kentytsyld kffsrkedte mletepvedg klgergheeg
      661 flnnsgeflf nkqlesigip qfhspvgspl ksiqatltps amksspqiph qtyssilkhl
      721 n
//
LOCUS       XP_047288808             721 aa            linear   PRI 05-AUG-2025
DEFINITION  mitogen-activated protein kinase 6 isoform X1 [Homo sapiens].
ACCESSION   XP_047288808
VERSION     XP_047288808.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432852.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..721
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..721
                     /product="mitogen-activated protein kinase 6 isoform X1"
                     /calculated_mol_wt=82550
     Region          14..355
                     /region_name="STKc_MAPK4_6"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     Mitogen-Activated Protein Kinases 4 (also called ERK4) and
                     6 (also called ERK3); cd07854"
                     /db_xref="CDD:143359"
     Site            order(26..29,31..32,34,47,49,64,78,108..111,114,116..117,
                     152,154,156..157,159,170..171,174,189,191..194,196,234)
                     /site_type="active"
                     /db_xref="CDD:143359"
     Site            order(26..29,31..32,34,47,49,78,108..111,114,117,154,
                     156..157,159,170..171)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:143359"
     Site            order(64,116,152,154,174,189,191..194,196,234)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:143359"
     Site            order(75,112..113,118,128,131,138,160..163,165,319,321,
                     324)
                     /site_type="other"
                     /note="KIM docking site [polypeptide binding]"
                     /db_xref="CDD:143359"
     Site            170..196
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:143359"
     CDS             1..721
                     /gene="MAPK6"
                     /gene_synonym="ERK3; HsT17250; p97MAPK; PRKM6"
                     /coded_by="XM_047432852.1:962..3127"
                     /db_xref="GeneID:5597"
                     /db_xref="HGNC:HGNC:6879"
                     /db_xref="MIM:602904"
ORIGIN      
        1 maekfeslmn ihgfdlgsry mdlkplgcgg nglvfsavdn dcdkrvaikk ivltdpqsvk
       61 halreikiir rldhdnivkv feilgpsgsq ltddvgslte lnsvyivqey metdlanvle
      121 qgplleehar lfmyqllrgl kyihsanvlh rdlkpanlfi ntedlvlkig dfglarimdp
      181 hyshkghlse glvtkwyrsp rlllspnnyt kaidmwaagc ifaemltgkt lfagaheleq
      241 mqlilesipv vheedrqell svipvyirnd mtephkpltq llpgisreal dfleqiltfs
      301 pmdrltaeea lshpymsiys fpmdepissh pfhiedevdd illmdethsh iynweryhdc
      361 qfsehdwpvh nnfdidevql dpralsdvtd eeevqvdprk yldgdrekyl edpafdtnys
      421 tepcwqysdh henkycdlec shtcnyktrs ssyldnlvwr esevnhyyep kliidlsnwk
      481 eqskeksdkk gkskcerngl vkaqialeea sqqlagkere knqgfdfdsf iagtiqlssq
      541 heptdvvdkl ndlnssvsql elkslisksv sqekqekgma nlaqlealyq sswdsqfvsg
      601 gedcffinqf cevrkdeqve kentytsyld kffsrkedte mletepvedg klgergheeg
      661 flnnsgeflf nkqlesigip qfhspvgspl ksiqatltps amksspqiph qtyssilkhl
      721 n
//
LOCUS       XP_047288809             721 aa            linear   PRI 05-AUG-2025
DEFINITION  mitogen-activated protein kinase 6 isoform X1 [Homo sapiens].
ACCESSION   XP_047288809
VERSION     XP_047288809.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432853.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..721
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..721
                     /product="mitogen-activated protein kinase 6 isoform X1"
                     /calculated_mol_wt=82550
     Region          14..355
                     /region_name="STKc_MAPK4_6"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     Mitogen-Activated Protein Kinases 4 (also called ERK4) and
                     6 (also called ERK3); cd07854"
                     /db_xref="CDD:143359"
     Site            order(26..29,31..32,34,47,49,64,78,108..111,114,116..117,
                     152,154,156..157,159,170..171,174,189,191..194,196,234)
                     /site_type="active"
                     /db_xref="CDD:143359"
     Site            order(26..29,31..32,34,47,49,78,108..111,114,117,154,
                     156..157,159,170..171)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:143359"
     Site            order(64,116,152,154,174,189,191..194,196,234)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:143359"
     Site            order(75,112..113,118,128,131,138,160..163,165,319,321,
                     324)
                     /site_type="other"
                     /note="KIM docking site [polypeptide binding]"
                     /db_xref="CDD:143359"
     Site            170..196
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:143359"
     CDS             1..721
                     /gene="MAPK6"
                     /gene_synonym="ERK3; HsT17250; p97MAPK; PRKM6"
                     /coded_by="XM_047432853.1:841..3006"
                     /db_xref="GeneID:5597"
                     /db_xref="HGNC:HGNC:6879"
                     /db_xref="MIM:602904"
ORIGIN      
        1 maekfeslmn ihgfdlgsry mdlkplgcgg nglvfsavdn dcdkrvaikk ivltdpqsvk
       61 halreikiir rldhdnivkv feilgpsgsq ltddvgslte lnsvyivqey metdlanvle
      121 qgplleehar lfmyqllrgl kyihsanvlh rdlkpanlfi ntedlvlkig dfglarimdp
      181 hyshkghlse glvtkwyrsp rlllspnnyt kaidmwaagc ifaemltgkt lfagaheleq
      241 mqlilesipv vheedrqell svipvyirnd mtephkpltq llpgisreal dfleqiltfs
      301 pmdrltaeea lshpymsiys fpmdepissh pfhiedevdd illmdethsh iynweryhdc
      361 qfsehdwpvh nnfdidevql dpralsdvtd eeevqvdprk yldgdrekyl edpafdtnys
      421 tepcwqysdh henkycdlec shtcnyktrs ssyldnlvwr esevnhyyep kliidlsnwk
      481 eqskeksdkk gkskcerngl vkaqialeea sqqlagkere knqgfdfdsf iagtiqlssq
      541 heptdvvdkl ndlnssvsql elkslisksv sqekqekgma nlaqlealyq sswdsqfvsg
      601 gedcffinqf cevrkdeqve kentytsyld kffsrkedte mletepvedg klgergheeg
      661 flnnsgeflf nkqlesigip qfhspvgspl ksiqatltps amksspqiph qtyssilkhl
      721 n
//
LOCUS       XP_047288810             721 aa            linear   PRI 05-AUG-2025
DEFINITION  mitogen-activated protein kinase 6 isoform X1 [Homo sapiens].
ACCESSION   XP_047288810
VERSION     XP_047288810.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432854.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..721
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..721
                     /product="mitogen-activated protein kinase 6 isoform X1"
                     /calculated_mol_wt=82550
     Region          14..355
                     /region_name="STKc_MAPK4_6"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     Mitogen-Activated Protein Kinases 4 (also called ERK4) and
                     6 (also called ERK3); cd07854"
                     /db_xref="CDD:143359"
     Site            order(26..29,31..32,34,47,49,64,78,108..111,114,116..117,
                     152,154,156..157,159,170..171,174,189,191..194,196,234)
                     /site_type="active"
                     /db_xref="CDD:143359"
     Site            order(26..29,31..32,34,47,49,78,108..111,114,117,154,
                     156..157,159,170..171)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:143359"
     Site            order(64,116,152,154,174,189,191..194,196,234)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:143359"
     Site            order(75,112..113,118,128,131,138,160..163,165,319,321,
                     324)
                     /site_type="other"
                     /note="KIM docking site [polypeptide binding]"
                     /db_xref="CDD:143359"
     Site            170..196
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:143359"
     CDS             1..721
                     /gene="MAPK6"
                     /gene_synonym="ERK3; HsT17250; p97MAPK; PRKM6"
                     /coded_by="XM_047432854.1:2519..4684"
                     /db_xref="GeneID:5597"
                     /db_xref="HGNC:HGNC:6879"
                     /db_xref="MIM:602904"
ORIGIN      
        1 maekfeslmn ihgfdlgsry mdlkplgcgg nglvfsavdn dcdkrvaikk ivltdpqsvk
       61 halreikiir rldhdnivkv feilgpsgsq ltddvgslte lnsvyivqey metdlanvle
      121 qgplleehar lfmyqllrgl kyihsanvlh rdlkpanlfi ntedlvlkig dfglarimdp
      181 hyshkghlse glvtkwyrsp rlllspnnyt kaidmwaagc ifaemltgkt lfagaheleq
      241 mqlilesipv vheedrqell svipvyirnd mtephkpltq llpgisreal dfleqiltfs
      301 pmdrltaeea lshpymsiys fpmdepissh pfhiedevdd illmdethsh iynweryhdc
      361 qfsehdwpvh nnfdidevql dpralsdvtd eeevqvdprk yldgdrekyl edpafdtnys
      421 tepcwqysdh henkycdlec shtcnyktrs ssyldnlvwr esevnhyyep kliidlsnwk
      481 eqskeksdkk gkskcerngl vkaqialeea sqqlagkere knqgfdfdsf iagtiqlssq
      541 heptdvvdkl ndlnssvsql elkslisksv sqekqekgma nlaqlealyq sswdsqfvsg
      601 gedcffinqf cevrkdeqve kentytsyld kffsrkedte mletepvedg klgergheeg
      661 flnnsgeflf nkqlesigip qfhspvgspl ksiqatltps amksspqiph qtyssilkhl
      721 n
//
LOCUS       XP_047288811             234 aa            linear   PRI 05-AUG-2025
DEFINITION  mitogen-activated protein kinase 6 isoform X2 [Homo sapiens].
ACCESSION   XP_047288811
VERSION     XP_047288811.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432855.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..234
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..234
                     /product="mitogen-activated protein kinase 6 isoform X2"
                     /calculated_mol_wt=26199
     Region          14..>234
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Site            order(26..29,32,34,47,49,78,108..111,152,156..157,159,
                     170..171)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270870"
     CDS             1..234
                     /gene="MAPK6"
                     /gene_synonym="ERK3; HsT17250; p97MAPK; PRKM6"
                     /coded_by="XM_047432855.1:790..1494"
                     /db_xref="GeneID:5597"
                     /db_xref="HGNC:HGNC:6879"
                     /db_xref="MIM:602904"
ORIGIN      
        1 maekfeslmn ihgfdlgsry mdlkplgcgg nglvfsavdn dcdkrvaikk ivltdpqsvk
       61 halreikiir rldhdnivkv feilgpsgsq ltddvgslte lnsvyivqey metdlanvle
      121 qgplleehar lfmyqllrgl kyihsanvlh rdlkpanlfi ntedlvlkig dfglarimdp
      181 hyshkghlse glvtkwyrsp rlllspnnyt kaidmwaagc ifaemltgkt lfag
//
LOCUS       XP_011520085             371 aa            linear   PRI 05-AUG-2025
DEFINITION  dual specificity mitogen-activated protein kinase kinase 1 isoform
            X1 [Homo sapiens].
ACCESSION   XP_011520085
VERSION     XP_011520085.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521783.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..371
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..371
                     /product="dual specificity mitogen-activated protein
                     kinase kinase 1 isoform X1"
                     /calculated_mol_wt=41248
     Region          40..358
                     /region_name="PKc_MEK1"
                     /note="Catalytic domain of the dual-specificity Protein
                     Kinase, Mitogen-Activated Protein (MAP)/Extracellular
                     signal-Regulated Kinase (ERK) Kinase 1; cd06650"
                     /db_xref="CDD:270816"
     Site            order(52..56,60,73,75,105,121..124,127..128,131,168,
                     170..173,175,185..186,189,201..204,206,233,242)
                     /site_type="active"
                     /db_xref="CDD:270816"
     Site            order(52..56,58,60,73,75,105,121..124,127..128,130..131,
                     170,172..173,175,186)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270816"
     Site            order(55..56,168,170..172,189,201..204,206,233,242)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270816"
     Site            order(55..56,75,93,96,105,119,121,186..187,189..190,
                     193..194,197)
                     /site_type="other"
                     /note="noncompetitive inhibitor binding site [chemical
                     binding]"
                     /db_xref="CDD:270816"
     Site            order(59,79..80,115,208,212..215,289,292..293,296..297)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:270816"
     Site            185..206
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270816"
     Site            order(199..204,206,208,212..215,287..289,292..293,296)
                     /site_type="other"
                     /note="KSR interface [polypeptide binding]"
                     /db_xref="CDD:270816"
     CDS             1..371
                     /gene="MAP2K1"
                     /gene_synonym="CFC3; MAPKK1; MEK1; MEL; MKK1; PRKMK1"
                     /coded_by="XM_011521783.4:56..1171"
                     /db_xref="GeneID:5604"
                     /db_xref="HGNC:HGNC:6840"
                     /db_xref="MIM:176872"
ORIGIN      
        1 mklertnlea lqkkleelel deqqrkrlea fltqkqkvge lkdddfekis elgagnggvv
       61 fkvshkpsgl vmarklihle ikpairnqii relqvlhecn spyivgfyga fysdgeisic
      121 mehmdggsld qvlkkagrip eqilgkvsia vikgltylre khkimhrdvk psnilvnsrg
      181 eiklcdfgvs gqlidsmans fvgtrsymsp erlqgthysv qsdiwsmgls lvemavgryp
      241 ipppdakele lmfgcqvegd aaetpprprt pgrplssygm dsrppmaife lldyivnepp
      301 pklpsgvfsl efqdfvnkcl iknpaeradl kqlmvhafik rsdaeevdfa gwlcstigln
      361 qpstpthaag v
//
LOCUS       XP_016877900             367 aa            linear   PRI 05-AUG-2025
DEFINITION  dual specificity mitogen-activated protein kinase kinase 1 isoform
            X2 [Homo sapiens].
ACCESSION   XP_016877900
VERSION     XP_016877900.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022411.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..367
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..367
                     /product="dual specificity mitogen-activated protein
                     kinase kinase 1 isoform X2"
                     /calculated_mol_wt=40633
     Region          62..354
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Site            order(74..77,80,82,95,97,127,143..146,164,168..169,171,
                     181..182)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270870"
     CDS             1..367
                     /gene="MAP2K1"
                     /gene_synonym="CFC3; MAPKK1; MEK1; MEL; MKK1; PRKMK1"
                     /coded_by="XM_017022411.3:437..1540"
                     /db_xref="GeneID:5604"
                     /db_xref="HGNC:HGNC:6840"
                     /db_xref="MIM:176872"
ORIGIN      
        1 mpkkkptpiq lnpapdgsav ngtssaetnl ealqkkleel eldeqqrkrl eafltqkqkv
       61 gelkdddfek iselgagngg vvfkvshkps glvmarklih leikpairnq iirelqvlhe
      121 cnspyivgfy gafysdgeis icmehmvikg ltylrekhki mhrdvkpsni lvnsrgeikl
      181 cdfgvsgqli dsmansfvgt rsymsperlq gthysvqsdi wsmglslvem avgrypippp
      241 dakelelmfg cqvegdaaet pprprtpgrp lssygmdsrp pmaifelldy ivnepppklp
      301 sgvfslefqd fvnkcliknp aeradlkqlm vhafikrsda eevdfagwlc stiglnqpst
      361 pthaagv
//
LOCUS       XP_011520089             289 aa            linear   PRI 05-AUG-2025
DEFINITION  dual specificity mitogen-activated protein kinase kinase 5 isoform
            X1 [Homo sapiens].
ACCESSION   XP_011520089
VERSION     XP_011520089.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521787.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..289
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..289
                     /product="dual specificity mitogen-activated protein
                     kinase kinase 5 isoform X1"
                     /calculated_mol_wt=32161
     Region          17..107
                     /region_name="PB1_Map2k5"
                     /note="PB1 domain is essential part of the
                     mitogen-activated protein kinase kinase 5 (Map2k5, alias
                     MEK5) one of the key member of the signaling kinases
                     cascade which involved in angiogenesis and early
                     cardiovascular development. The PB1 domain of Map2k5...;
                     cd06395"
                     /db_xref="CDD:99717"
     Site            order(64,66,68,77)
                     /site_type="other"
                     /note="PB1 interaction surface [polypeptide binding]"
                     /db_xref="CDD:99717"
     Region          164..>282
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..289
                     /gene="MAP2K5"
                     /gene_synonym="HsT17454; MAPKK5; MEK5; PRKMK5"
                     /coded_by="XM_011521787.4:634..1503"
                     /db_xref="GeneID:5607"
                     /db_xref="HGNC:HGNC:6845"
                     /db_xref="MIM:602520"
ORIGIN      
        1 mlwlalgpfp amenqvlvir ikipnsgavd wtvhsgpqll frdvldvigq vlpeatttaf
       61 eyededgdri tvrsdeemka mlsyyystvm eqqvngqlie plqifprack ppgernihgl
      121 kvntragpsq hsspavsdsl psnslkkssa elkkilangq mneqdiryrd tlghgnggtv
      181 ykayhvpsgk ilavkvilld itlelqkqim seleilykcd ssyiigfyga ffvenrisic
      241 tefmdggsld vyrkmpehvl griavavvkg ltylwslkil hrankdlct
//
LOCUS       XP_011520090             283 aa            linear   PRI 05-AUG-2025
DEFINITION  dual specificity mitogen-activated protein kinase kinase 5 isoform
            X2 [Homo sapiens].
ACCESSION   XP_011520090
VERSION     XP_011520090.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521788.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..283
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..283
                     /product="dual specificity mitogen-activated protein
                     kinase kinase 5 isoform X2"
                     /calculated_mol_wt=31472
     Region          17..107
                     /region_name="PB1_Map2k5"
                     /note="PB1 domain is essential part of the
                     mitogen-activated protein kinase kinase 5 (Map2k5, alias
                     MEK5) one of the key member of the signaling kinases
                     cascade which involved in angiogenesis and early
                     cardiovascular development. The PB1 domain of Map2k5...;
                     cd06395"
                     /db_xref="CDD:99717"
     Site            order(64,66,68,77)
                     /site_type="other"
                     /note="PB1 interaction surface [polypeptide binding]"
                     /db_xref="CDD:99717"
     Region          164..>282
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..283
                     /gene="MAP2K5"
                     /gene_synonym="HsT17454; MAPKK5; MEK5; PRKMK5"
                     /coded_by="XM_011521788.4:634..1485"
                     /db_xref="GeneID:5607"
                     /db_xref="HGNC:HGNC:6845"
                     /db_xref="MIM:602520"
ORIGIN      
        1 mlwlalgpfp amenqvlvir ikipnsgavd wtvhsgpqll frdvldvigq vlpeatttaf
       61 eyededgdri tvrsdeemka mlsyyystvm eqqvngqlie plqifprack ppgernihgl
      121 kvntragpsq hsspavsdsl psnslkkssa elkkilangq mneqdiryrd tlghgnggtv
      181 ykayhvpsgk ilavkvilld itlelqkqim seleilykcd ssyiigfyga ffvenrisic
      241 tefmdggsld vyrkmpehvl griavavvkg ltylwslkil hrg
//
LOCUS       XP_016877903             267 aa            linear   PRI 05-AUG-2025
DEFINITION  dual specificity mitogen-activated protein kinase kinase 5 isoform
            X3 [Homo sapiens].
ACCESSION   XP_016877903
VERSION     XP_016877903.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022414.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..267
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..267
                     /product="dual specificity mitogen-activated protein
                     kinase kinase 5 isoform X3"
                     /calculated_mol_wt=29635
     Region          17..107
                     /region_name="PB1_Map2k5"
                     /note="PB1 domain is essential part of the
                     mitogen-activated protein kinase kinase 5 (Map2k5, alias
                     MEK5) one of the key member of the signaling kinases
                     cascade which involved in angiogenesis and early
                     cardiovascular development. The PB1 domain of Map2k5...;
                     cd06395"
                     /db_xref="CDD:99717"
     Site            order(64,66,68,77)
                     /site_type="other"
                     /note="PB1 interaction surface [polypeptide binding]"
                     /db_xref="CDD:99717"
     Region          164..>266
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..267
                     /gene="MAP2K5"
                     /gene_synonym="HsT17454; MAPKK5; MEK5; PRKMK5"
                     /coded_by="XM_017022414.3:634..1437"
                     /db_xref="GeneID:5607"
                     /db_xref="HGNC:HGNC:6845"
                     /db_xref="MIM:602520"
ORIGIN      
        1 mlwlalgpfp amenqvlvir ikipnsgavd wtvhsgpqll frdvldvigq vlpeatttaf
       61 eyededgdri tvrsdeemka mlsyyystvm eqqvngqlie plqifprack ppgernihgl
      121 kvntragpsq hsspavsdsl psnslkkssa elkkilangq mneqdiryrd tlghgnggtv
      181 ykayhvpsgk ilavkvilld itlelqkqim seleilykcd ssyiigfyga ffvenrisic
      241 tefmdggsld vyrkmpehvl griavaq
//
LOCUS       XP_047288812             247 aa            linear   PRI 05-AUG-2025
DEFINITION  dual specificity mitogen-activated protein kinase kinase 5 isoform
            X4 [Homo sapiens].
ACCESSION   XP_047288812
VERSION     XP_047288812.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432856.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..247
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..247
                     /product="dual specificity mitogen-activated protein
                     kinase kinase 5 isoform X4"
                     /calculated_mol_wt=27492
     Region          <10..71
                     /region_name="PB1"
                     /note="The PB1 domain is a modular domain mediating
                     specific protein-protein interactions which play a role in
                     many critical cell processes, such as osteoclastogenesis,
                     angiogenesis, early cardiovascular development, and cell
                     polarity. A canonical PB1-PB1...; cl02720"
                     /db_xref="CDD:413452"
     Site            order(28,41)
                     /site_type="other"
                     /note="PB1 interaction site [polypeptide binding]"
                     /db_xref="CDD:99717"
     Site            order(28,41)
                     /site_type="other"
                     /note="PB1 interaction site [polypeptide binding]"
                     /db_xref="CDD:99717"
     Site            order(28,41)
                     /site_type="other"
                     /note="PB1 interaction surface [polypeptide binding]"
                     /db_xref="CDD:99717"
     Site            order(28,41)
                     /site_type="other"
                     /note="PB1 interaction surface [polypeptide binding]"
                     /db_xref="CDD:99717"
     Region          128..>246
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..247
                     /gene="MAP2K5"
                     /gene_synonym="HsT17454; MAPKK5; MEK5; PRKMK5"
                     /coded_by="XM_047432856.1:88..831"
                     /db_xref="GeneID:5607"
                     /db_xref="HGNC:HGNC:6845"
                     /db_xref="MIM:602520"
ORIGIN      
        1 mmeghfpqsd vigqvlpeat ttafeyeded gdritvrsde emkamlsyyy stvmeqqvng
       61 qlieplqifp rackppgern ihglkvntra gpsqhsspav sdslpsnslk kssaelkkil
      121 angqmneqdi ryrdtlghgn ggtvykayhv psgkilavkv illditlelq kqimseleil
      181 ykcdssyiig fygaffvenr isictefmdg gsldvyrkmp ehvlgriava vvkgltylws
      241 lkilhrg
//
LOCUS       XP_047288813            1076 aa            linear   PRI 05-AUG-2025
DEFINITION  atos homolog protein A isoform X1 [Homo sapiens].
ACCESSION   XP_047288813
VERSION     XP_047288813.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432857.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 3% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1076
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1076
                     /product="atos homolog protein A isoform X1"
                     /calculated_mol_wt=121539
     Region          <470..>520
                     /region_name="TroA-like"
                     /note="Helical backbone metal receptor (TroA-like domain).
                     These proteins have been shown to function in the ABC
                     transport of ferric siderophores and metal ions such as
                     Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is
                     formed in the interface between...; cl00262"
                     /db_xref="CDD:469696"
     Region          <592..>788
                     /region_name="SCP-1"
                     /note="Synaptonemal complex protein 1 (SCP-1); pfam05483"
                     /db_xref="CDD:114219"
     Region          878..935
                     /region_name="DUF4210"
                     /note="Domain of unknown function (DUF4210); pfam13915"
                     /db_xref="CDD:404751"
     Region          1018..1075
                     /region_name="Chromosome_seg"
                     /note="Chromosome segregation during meiosis; pfam13889"
                     /db_xref="CDD:464021"
     CDS             1..1076
                     /gene="ATOSA"
                     /gene_synonym="FAM214A; KIAA1370"
                     /coded_by="XM_047432857.1:479..3709"
                     /db_xref="GeneID:56204"
                     /db_xref="HGNC:HGNC:25609"
                     /db_xref="MIM:620168"
ORIGIN      
        1 mkpdrdtlde yfeydaeefl vslalliteg rtpecsvkgr tesfhcppaq scypvttkhe
       61 csdklaqcrq arrtrsevtl lwknnlpimv emmllpdccy sddgpttegi dlndpaikqd
      121 alllerwile pvprqngdrf ieektlllav rsfvffsqls awlsvshgai prnilyrisa
      181 advdlqwnfs qtpiehvfpv pnvshnvalk vsvqslprqs nypvltcsih tniglyekri
      241 qqhklkthqh hnpneaeqcg tnssqrlcsk qtwtmapesv lhaksgpspe ytaavknikl
      301 ypgtgsksdh gtsqanilgf sgigdiksqe tsvrtlksfs mvdssisnrq sfwqsagetn
      361 pligsliqer qeiiariaqh lihcdpstsh vsgrpfntqe ssslhsklfr vsqenenvgk
      421 gkeafsmtfg spefsspedt negkirlkpe tprsetcisn dfyshmpvge tnpligsllq
      481 erqdviaria qhlehidpta shiprqsfnm hdsssvaskv frssyedknl lkknkdessv
      541 sishtkcsll gdisdgknlv pnkcftsfkn nskekcslkh qtrnqcqnnp seiiqstyqe
      601 tqnkssslst ssilsqhken nldltsrfke qemsngidkq ysncttidkq ictnkykeki
      661 inenynpkff gnlqsddskk ndskikvtvl emseylnkye smssnkdskr pktceqntql
      721 nsienylnkd negfkckksd qlkneqdkqe dptneksqny sqrrsikdcl stceqpknte
      781 vlrttlkhsn vwrkhnfhsl dgtstrafhp qtglpllssp vpqrktqsgc fdldssllhl
      841 ksfssrsprp clnieddpdi hekpflsssa ppitslsllg nfeesvlnyr fdplgivdgf
      901 taevgasgaf cpthltlpve vsfysvsddn apspymgvit leslgkrgyr vppsgtiqvt
      961 lfnpnktvvk mfvviydlrd mpanhqtflr qrtfsvpvkq evkrsvnken irhteerllr
     1021 ylihlrfqss ksgkiylhrd vrllfsrksm evdsgaayel ksytesptnp qfsprc
//
LOCUS       XP_024305759            1076 aa            linear   PRI 05-AUG-2025
DEFINITION  atos homolog protein A isoform X1 [Homo sapiens].
ACCESSION   XP_024305759
VERSION     XP_024305759.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449991.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1076
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1076
                     /product="atos homolog protein A isoform X1"
                     /calculated_mol_wt=121539
     Region          <470..>520
                     /region_name="TroA-like"
                     /note="Helical backbone metal receptor (TroA-like domain).
                     These proteins have been shown to function in the ABC
                     transport of ferric siderophores and metal ions such as
                     Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is
                     formed in the interface between...; cl00262"
                     /db_xref="CDD:469696"
     Region          <592..>788
                     /region_name="SCP-1"
                     /note="Synaptonemal complex protein 1 (SCP-1); pfam05483"
                     /db_xref="CDD:114219"
     Region          878..935
                     /region_name="DUF4210"
                     /note="Domain of unknown function (DUF4210); pfam13915"
                     /db_xref="CDD:404751"
     Region          1018..1075
                     /region_name="Chromosome_seg"
                     /note="Chromosome segregation during meiosis; pfam13889"
                     /db_xref="CDD:464021"
     CDS             1..1076
                     /gene="ATOSA"
                     /gene_synonym="FAM214A; KIAA1370"
                     /coded_by="XM_024449991.2:393..3623"
                     /db_xref="GeneID:56204"
                     /db_xref="HGNC:HGNC:25609"
                     /db_xref="MIM:620168"
ORIGIN      
        1 mkpdrdtlde yfeydaeefl vslalliteg rtpecsvkgr tesfhcppaq scypvttkhe
       61 csdklaqcrq arrtrsevtl lwknnlpimv emmllpdccy sddgpttegi dlndpaikqd
      121 alllerwile pvprqngdrf ieektlllav rsfvffsqls awlsvshgai prnilyrisa
      181 advdlqwnfs qtpiehvfpv pnvshnvalk vsvqslprqs nypvltcsih tniglyekri
      241 qqhklkthqh hnpneaeqcg tnssqrlcsk qtwtmapesv lhaksgpspe ytaavknikl
      301 ypgtgsksdh gtsqanilgf sgigdiksqe tsvrtlksfs mvdssisnrq sfwqsagetn
      361 pligsliqer qeiiariaqh lihcdpstsh vsgrpfntqe ssslhsklfr vsqenenvgk
      421 gkeafsmtfg spefsspedt negkirlkpe tprsetcisn dfyshmpvge tnpligsllq
      481 erqdviaria qhlehidpta shiprqsfnm hdsssvaskv frssyedknl lkknkdessv
      541 sishtkcsll gdisdgknlv pnkcftsfkn nskekcslkh qtrnqcqnnp seiiqstyqe
      601 tqnkssslst ssilsqhken nldltsrfke qemsngidkq ysncttidkq ictnkykeki
      661 inenynpkff gnlqsddskk ndskikvtvl emseylnkye smssnkdskr pktceqntql
      721 nsienylnkd negfkckksd qlkneqdkqe dptneksqny sqrrsikdcl stceqpknte
      781 vlrttlkhsn vwrkhnfhsl dgtstrafhp qtglpllssp vpqrktqsgc fdldssllhl
      841 ksfssrsprp clnieddpdi hekpflsssa ppitslsllg nfeesvlnyr fdplgivdgf
      901 taevgasgaf cpthltlpve vsfysvsddn apspymgvit leslgkrgyr vppsgtiqvt
      961 lfnpnktvvk mfvviydlrd mpanhqtflr qrtfsvpvkq evkrsvnken irhteerllr
     1021 ylihlrfqss ksgkiylhrd vrllfsrksm evdsgaayel ksytesptnp qfsprc
//
LOCUS       XP_047288814            1053 aa            linear   PRI 05-AUG-2025
DEFINITION  atos homolog protein A isoform X2 [Homo sapiens].
ACCESSION   XP_047288814
VERSION     XP_047288814.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432858.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1053
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1053
                     /product="atos homolog protein A isoform X2"
                     /calculated_mol_wt=119129
     Region          <470..>520
                     /region_name="TroA-like"
                     /note="Helical backbone metal receptor (TroA-like domain).
                     These proteins have been shown to function in the ABC
                     transport of ferric siderophores and metal ions such as
                     Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is
                     formed in the interface between...; cl00262"
                     /db_xref="CDD:469696"
     Region          <592..>788
                     /region_name="SCP-1"
                     /note="Synaptonemal complex protein 1 (SCP-1); pfam05483"
                     /db_xref="CDD:114219"
     Region          878..935
                     /region_name="DUF4210"
                     /note="Domain of unknown function (DUF4210); pfam13915"
                     /db_xref="CDD:404751"
     Region          995..1052
                     /region_name="Chromosome_seg"
                     /note="Chromosome segregation during meiosis; pfam13889"
                     /db_xref="CDD:464021"
     CDS             1..1053
                     /gene="ATOSA"
                     /gene_synonym="FAM214A; KIAA1370"
                     /coded_by="XM_047432858.1:430..3591"
                     /db_xref="GeneID:56204"
                     /db_xref="HGNC:HGNC:25609"
                     /db_xref="MIM:620168"
ORIGIN      
        1 mkpdrdtlde yfeydaeefl vslalliteg rtpecsvkgr tesfhcppaq scypvttkhe
       61 csdklaqcrq arrtrsevtl lwknnlpimv emmllpdccy sddgpttegi dlndpaikqd
      121 alllerwile pvprqngdrf ieektlllav rsfvffsqls awlsvshgai prnilyrisa
      181 advdlqwnfs qtpiehvfpv pnvshnvalk vsvqslprqs nypvltcsih tniglyekri
      241 qqhklkthqh hnpneaeqcg tnssqrlcsk qtwtmapesv lhaksgpspe ytaavknikl
      301 ypgtgsksdh gtsqanilgf sgigdiksqe tsvrtlksfs mvdssisnrq sfwqsagetn
      361 pligsliqer qeiiariaqh lihcdpstsh vsgrpfntqe ssslhsklfr vsqenenvgk
      421 gkeafsmtfg spefsspedt negkirlkpe tprsetcisn dfyshmpvge tnpligsllq
      481 erqdviaria qhlehidpta shiprqsfnm hdsssvaskv frssyedknl lkknkdessv
      541 sishtkcsll gdisdgknlv pnkcftsfkn nskekcslkh qtrnqcqnnp seiiqstyqe
      601 tqnkssslst ssilsqhken nldltsrfke qemsngidkq ysncttidkq ictnkykeki
      661 inenynpkff gnlqsddskk ndskikvtvl emseylnkye smssnkdskr pktceqntql
      721 nsienylnkd negfkckksd qlkneqdkqe dptneksqny sqrrsikdcl stceqpknte
      781 vlrttlkhsn vwrkhnfhsl dgtstrafhp qtglpllssp vpqrktqsgc fdldssllhl
      841 ksfssrsprp clnieddpdi hekpflsssa ppitslsllg nfeesvlnyr fdplgivdgf
      901 taevgasgaf cpthltlpve vsfysvsddn apspymtlfn pnktvvkmfv viydlrdmpa
      961 nhqtflrqrt fsvpvkqevk rsvnkenirh teerllryli hlrfqssksg kiylhrdvrl
     1021 lfsrksmevd sgaayelksy tesptnpqfs prc
//
LOCUS       XP_047288815            1053 aa            linear   PRI 05-AUG-2025
DEFINITION  atos homolog protein A isoform X2 [Homo sapiens].
ACCESSION   XP_047288815
VERSION     XP_047288815.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432859.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1053
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1053
                     /product="atos homolog protein A isoform X2"
                     /calculated_mol_wt=119129
     Region          <470..>520
                     /region_name="TroA-like"
                     /note="Helical backbone metal receptor (TroA-like domain).
                     These proteins have been shown to function in the ABC
                     transport of ferric siderophores and metal ions such as
                     Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is
                     formed in the interface between...; cl00262"
                     /db_xref="CDD:469696"
     Region          <592..>788
                     /region_name="SCP-1"
                     /note="Synaptonemal complex protein 1 (SCP-1); pfam05483"
                     /db_xref="CDD:114219"
     Region          878..935
                     /region_name="DUF4210"
                     /note="Domain of unknown function (DUF4210); pfam13915"
                     /db_xref="CDD:404751"
     Region          995..1052
                     /region_name="Chromosome_seg"
                     /note="Chromosome segregation during meiosis; pfam13889"
                     /db_xref="CDD:464021"
     CDS             1..1053
                     /gene="ATOSA"
                     /gene_synonym="FAM214A; KIAA1370"
                     /coded_by="XM_047432859.1:663..3824"
                     /db_xref="GeneID:56204"
                     /db_xref="HGNC:HGNC:25609"
                     /db_xref="MIM:620168"
ORIGIN      
        1 mkpdrdtlde yfeydaeefl vslalliteg rtpecsvkgr tesfhcppaq scypvttkhe
       61 csdklaqcrq arrtrsevtl lwknnlpimv emmllpdccy sddgpttegi dlndpaikqd
      121 alllerwile pvprqngdrf ieektlllav rsfvffsqls awlsvshgai prnilyrisa
      181 advdlqwnfs qtpiehvfpv pnvshnvalk vsvqslprqs nypvltcsih tniglyekri
      241 qqhklkthqh hnpneaeqcg tnssqrlcsk qtwtmapesv lhaksgpspe ytaavknikl
      301 ypgtgsksdh gtsqanilgf sgigdiksqe tsvrtlksfs mvdssisnrq sfwqsagetn
      361 pligsliqer qeiiariaqh lihcdpstsh vsgrpfntqe ssslhsklfr vsqenenvgk
      421 gkeafsmtfg spefsspedt negkirlkpe tprsetcisn dfyshmpvge tnpligsllq
      481 erqdviaria qhlehidpta shiprqsfnm hdsssvaskv frssyedknl lkknkdessv
      541 sishtkcsll gdisdgknlv pnkcftsfkn nskekcslkh qtrnqcqnnp seiiqstyqe
      601 tqnkssslst ssilsqhken nldltsrfke qemsngidkq ysncttidkq ictnkykeki
      661 inenynpkff gnlqsddskk ndskikvtvl emseylnkye smssnkdskr pktceqntql
      721 nsienylnkd negfkckksd qlkneqdkqe dptneksqny sqrrsikdcl stceqpknte
      781 vlrttlkhsn vwrkhnfhsl dgtstrafhp qtglpllssp vpqrktqsgc fdldssllhl
      841 ksfssrsprp clnieddpdi hekpflsssa ppitslsllg nfeesvlnyr fdplgivdgf
      901 taevgasgaf cpthltlpve vsfysvsddn apspymtlfn pnktvvkmfv viydlrdmpa
      961 nhqtflrqrt fsvpvkqevk rsvnkenirh teerllryli hlrfqssksg kiylhrdvrl
     1021 lfsrksmevd sgaayelksy tesptnpqfs prc
//
LOCUS       XP_047288816            1053 aa            linear   PRI 05-AUG-2025
DEFINITION  atos homolog protein A isoform X2 [Homo sapiens].
ACCESSION   XP_047288816
VERSION     XP_047288816.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432860.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1053
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1053
                     /product="atos homolog protein A isoform X2"
                     /calculated_mol_wt=119129
     Region          <470..>520
                     /region_name="TroA-like"
                     /note="Helical backbone metal receptor (TroA-like domain).
                     These proteins have been shown to function in the ABC
                     transport of ferric siderophores and metal ions such as
                     Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is
                     formed in the interface between...; cl00262"
                     /db_xref="CDD:469696"
     Region          <592..>788
                     /region_name="SCP-1"
                     /note="Synaptonemal complex protein 1 (SCP-1); pfam05483"
                     /db_xref="CDD:114219"
     Region          878..935
                     /region_name="DUF4210"
                     /note="Domain of unknown function (DUF4210); pfam13915"
                     /db_xref="CDD:404751"
     Region          995..1052
                     /region_name="Chromosome_seg"
                     /note="Chromosome segregation during meiosis; pfam13889"
                     /db_xref="CDD:464021"
     CDS             1..1053
                     /gene="ATOSA"
                     /gene_synonym="FAM214A; KIAA1370"
                     /coded_by="XM_047432860.1:288..3449"
                     /db_xref="GeneID:56204"
                     /db_xref="HGNC:HGNC:25609"
                     /db_xref="MIM:620168"
ORIGIN      
        1 mkpdrdtlde yfeydaeefl vslalliteg rtpecsvkgr tesfhcppaq scypvttkhe
       61 csdklaqcrq arrtrsevtl lwknnlpimv emmllpdccy sddgpttegi dlndpaikqd
      121 alllerwile pvprqngdrf ieektlllav rsfvffsqls awlsvshgai prnilyrisa
      181 advdlqwnfs qtpiehvfpv pnvshnvalk vsvqslprqs nypvltcsih tniglyekri
      241 qqhklkthqh hnpneaeqcg tnssqrlcsk qtwtmapesv lhaksgpspe ytaavknikl
      301 ypgtgsksdh gtsqanilgf sgigdiksqe tsvrtlksfs mvdssisnrq sfwqsagetn
      361 pligsliqer qeiiariaqh lihcdpstsh vsgrpfntqe ssslhsklfr vsqenenvgk
      421 gkeafsmtfg spefsspedt negkirlkpe tprsetcisn dfyshmpvge tnpligsllq
      481 erqdviaria qhlehidpta shiprqsfnm hdsssvaskv frssyedknl lkknkdessv
      541 sishtkcsll gdisdgknlv pnkcftsfkn nskekcslkh qtrnqcqnnp seiiqstyqe
      601 tqnkssslst ssilsqhken nldltsrfke qemsngidkq ysncttidkq ictnkykeki
      661 inenynpkff gnlqsddskk ndskikvtvl emseylnkye smssnkdskr pktceqntql
      721 nsienylnkd negfkckksd qlkneqdkqe dptneksqny sqrrsikdcl stceqpknte
      781 vlrttlkhsn vwrkhnfhsl dgtstrafhp qtglpllssp vpqrktqsgc fdldssllhl
      841 ksfssrsprp clnieddpdi hekpflsssa ppitslsllg nfeesvlnyr fdplgivdgf
      901 taevgasgaf cpthltlpve vsfysvsddn apspymtlfn pnktvvkmfv viydlrdmpa
      961 nhqtflrqrt fsvpvkqevk rsvnkenirh teerllryli hlrfqssksg kiylhrdvrl
     1021 lfsrksmevd sgaayelksy tesptnpqfs prc
//
LOCUS       XP_047288817            1053 aa            linear   PRI 05-AUG-2025
DEFINITION  atos homolog protein A isoform X2 [Homo sapiens].
ACCESSION   XP_047288817
VERSION     XP_047288817.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432861.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1053
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1053
                     /product="atos homolog protein A isoform X2"
                     /calculated_mol_wt=119129
     Region          <470..>520
                     /region_name="TroA-like"
                     /note="Helical backbone metal receptor (TroA-like domain).
                     These proteins have been shown to function in the ABC
                     transport of ferric siderophores and metal ions such as
                     Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is
                     formed in the interface between...; cl00262"
                     /db_xref="CDD:469696"
     Region          <592..>788
                     /region_name="SCP-1"
                     /note="Synaptonemal complex protein 1 (SCP-1); pfam05483"
                     /db_xref="CDD:114219"
     Region          878..935
                     /region_name="DUF4210"
                     /note="Domain of unknown function (DUF4210); pfam13915"
                     /db_xref="CDD:404751"
     Region          995..1052
                     /region_name="Chromosome_seg"
                     /note="Chromosome segregation during meiosis; pfam13889"
                     /db_xref="CDD:464021"
     CDS             1..1053
                     /gene="ATOSA"
                     /gene_synonym="FAM214A; KIAA1370"
                     /coded_by="XM_047432861.1:192..3353"
                     /db_xref="GeneID:56204"
                     /db_xref="HGNC:HGNC:25609"
                     /db_xref="MIM:620168"
ORIGIN      
        1 mkpdrdtlde yfeydaeefl vslalliteg rtpecsvkgr tesfhcppaq scypvttkhe
       61 csdklaqcrq arrtrsevtl lwknnlpimv emmllpdccy sddgpttegi dlndpaikqd
      121 alllerwile pvprqngdrf ieektlllav rsfvffsqls awlsvshgai prnilyrisa
      181 advdlqwnfs qtpiehvfpv pnvshnvalk vsvqslprqs nypvltcsih tniglyekri
      241 qqhklkthqh hnpneaeqcg tnssqrlcsk qtwtmapesv lhaksgpspe ytaavknikl
      301 ypgtgsksdh gtsqanilgf sgigdiksqe tsvrtlksfs mvdssisnrq sfwqsagetn
      361 pligsliqer qeiiariaqh lihcdpstsh vsgrpfntqe ssslhsklfr vsqenenvgk
      421 gkeafsmtfg spefsspedt negkirlkpe tprsetcisn dfyshmpvge tnpligsllq
      481 erqdviaria qhlehidpta shiprqsfnm hdsssvaskv frssyedknl lkknkdessv
      541 sishtkcsll gdisdgknlv pnkcftsfkn nskekcslkh qtrnqcqnnp seiiqstyqe
      601 tqnkssslst ssilsqhken nldltsrfke qemsngidkq ysncttidkq ictnkykeki
      661 inenynpkff gnlqsddskk ndskikvtvl emseylnkye smssnkdskr pktceqntql
      721 nsienylnkd negfkckksd qlkneqdkqe dptneksqny sqrrsikdcl stceqpknte
      781 vlrttlkhsn vwrkhnfhsl dgtstrafhp qtglpllssp vpqrktqsgc fdldssllhl
      841 ksfssrsprp clnieddpdi hekpflsssa ppitslsllg nfeesvlnyr fdplgivdgf
      901 taevgasgaf cpthltlpve vsfysvsddn apspymtlfn pnktvvkmfv viydlrdmpa
      961 nhqtflrqrt fsvpvkqevk rsvnkenirh teerllryli hlrfqssksg kiylhrdvrl
     1021 lfsrksmevd sgaayelksy tesptnpqfs prc
//
LOCUS       XP_047288818            1053 aa            linear   PRI 05-AUG-2025
DEFINITION  atos homolog protein A isoform X2 [Homo sapiens].
ACCESSION   XP_047288818
VERSION     XP_047288818.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432862.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 3% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1053
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1053
                     /product="atos homolog protein A isoform X2"
                     /calculated_mol_wt=119129
     Region          <470..>520
                     /region_name="TroA-like"
                     /note="Helical backbone metal receptor (TroA-like domain).
                     These proteins have been shown to function in the ABC
                     transport of ferric siderophores and metal ions such as
                     Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is
                     formed in the interface between...; cl00262"
                     /db_xref="CDD:469696"
     Region          <592..>788
                     /region_name="SCP-1"
                     /note="Synaptonemal complex protein 1 (SCP-1); pfam05483"
                     /db_xref="CDD:114219"
     Region          878..935
                     /region_name="DUF4210"
                     /note="Domain of unknown function (DUF4210); pfam13915"
                     /db_xref="CDD:404751"
     Region          995..1052
                     /region_name="Chromosome_seg"
                     /note="Chromosome segregation during meiosis; pfam13889"
                     /db_xref="CDD:464021"
     CDS             1..1053
                     /gene="ATOSA"
                     /gene_synonym="FAM214A; KIAA1370"
                     /coded_by="XM_047432862.1:479..3640"
                     /db_xref="GeneID:56204"
                     /db_xref="HGNC:HGNC:25609"
                     /db_xref="MIM:620168"
ORIGIN      
        1 mkpdrdtlde yfeydaeefl vslalliteg rtpecsvkgr tesfhcppaq scypvttkhe
       61 csdklaqcrq arrtrsevtl lwknnlpimv emmllpdccy sddgpttegi dlndpaikqd
      121 alllerwile pvprqngdrf ieektlllav rsfvffsqls awlsvshgai prnilyrisa
      181 advdlqwnfs qtpiehvfpv pnvshnvalk vsvqslprqs nypvltcsih tniglyekri
      241 qqhklkthqh hnpneaeqcg tnssqrlcsk qtwtmapesv lhaksgpspe ytaavknikl
      301 ypgtgsksdh gtsqanilgf sgigdiksqe tsvrtlksfs mvdssisnrq sfwqsagetn
      361 pligsliqer qeiiariaqh lihcdpstsh vsgrpfntqe ssslhsklfr vsqenenvgk
      421 gkeafsmtfg spefsspedt negkirlkpe tprsetcisn dfyshmpvge tnpligsllq
      481 erqdviaria qhlehidpta shiprqsfnm hdsssvaskv frssyedknl lkknkdessv
      541 sishtkcsll gdisdgknlv pnkcftsfkn nskekcslkh qtrnqcqnnp seiiqstyqe
      601 tqnkssslst ssilsqhken nldltsrfke qemsngidkq ysncttidkq ictnkykeki
      661 inenynpkff gnlqsddskk ndskikvtvl emseylnkye smssnkdskr pktceqntql
      721 nsienylnkd negfkckksd qlkneqdkqe dptneksqny sqrrsikdcl stceqpknte
      781 vlrttlkhsn vwrkhnfhsl dgtstrafhp qtglpllssp vpqrktqsgc fdldssllhl
      841 ksfssrsprp clnieddpdi hekpflsssa ppitslsllg nfeesvlnyr fdplgivdgf
      901 taevgasgaf cpthltlpve vsfysvsddn apspymtlfn pnktvvkmfv viydlrdmpa
      961 nhqtflrqrt fsvpvkqevk rsvnkenirh teerllryli hlrfqssksg kiylhrdvrl
     1021 lfsrksmevd sgaayelksy tesptnpqfs prc
//
LOCUS       XP_047288819            1053 aa            linear   PRI 05-AUG-2025
DEFINITION  atos homolog protein A isoform X2 [Homo sapiens].
ACCESSION   XP_047288819
VERSION     XP_047288819.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432863.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1053
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1053
                     /product="atos homolog protein A isoform X2"
                     /calculated_mol_wt=119129
     Region          <470..>520
                     /region_name="TroA-like"
                     /note="Helical backbone metal receptor (TroA-like domain).
                     These proteins have been shown to function in the ABC
                     transport of ferric siderophores and metal ions such as
                     Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is
                     formed in the interface between...; cl00262"
                     /db_xref="CDD:469696"
     Region          <592..>788
                     /region_name="SCP-1"
                     /note="Synaptonemal complex protein 1 (SCP-1); pfam05483"
                     /db_xref="CDD:114219"
     Region          878..935
                     /region_name="DUF4210"
                     /note="Domain of unknown function (DUF4210); pfam13915"
                     /db_xref="CDD:404751"
     Region          995..1052
                     /region_name="Chromosome_seg"
                     /note="Chromosome segregation during meiosis; pfam13889"
                     /db_xref="CDD:464021"
     CDS             1..1053
                     /gene="ATOSA"
                     /gene_synonym="FAM214A; KIAA1370"
                     /coded_by="XM_047432863.1:393..3554"
                     /db_xref="GeneID:56204"
                     /db_xref="HGNC:HGNC:25609"
                     /db_xref="MIM:620168"
ORIGIN      
        1 mkpdrdtlde yfeydaeefl vslalliteg rtpecsvkgr tesfhcppaq scypvttkhe
       61 csdklaqcrq arrtrsevtl lwknnlpimv emmllpdccy sddgpttegi dlndpaikqd
      121 alllerwile pvprqngdrf ieektlllav rsfvffsqls awlsvshgai prnilyrisa
      181 advdlqwnfs qtpiehvfpv pnvshnvalk vsvqslprqs nypvltcsih tniglyekri
      241 qqhklkthqh hnpneaeqcg tnssqrlcsk qtwtmapesv lhaksgpspe ytaavknikl
      301 ypgtgsksdh gtsqanilgf sgigdiksqe tsvrtlksfs mvdssisnrq sfwqsagetn
      361 pligsliqer qeiiariaqh lihcdpstsh vsgrpfntqe ssslhsklfr vsqenenvgk
      421 gkeafsmtfg spefsspedt negkirlkpe tprsetcisn dfyshmpvge tnpligsllq
      481 erqdviaria qhlehidpta shiprqsfnm hdsssvaskv frssyedknl lkknkdessv
      541 sishtkcsll gdisdgknlv pnkcftsfkn nskekcslkh qtrnqcqnnp seiiqstyqe
      601 tqnkssslst ssilsqhken nldltsrfke qemsngidkq ysncttidkq ictnkykeki
      661 inenynpkff gnlqsddskk ndskikvtvl emseylnkye smssnkdskr pktceqntql
      721 nsienylnkd negfkckksd qlkneqdkqe dptneksqny sqrrsikdcl stceqpknte
      781 vlrttlkhsn vwrkhnfhsl dgtstrafhp qtglpllssp vpqrktqsgc fdldssllhl
      841 ksfssrsprp clnieddpdi hekpflsssa ppitslsllg nfeesvlnyr fdplgivdgf
      901 taevgasgaf cpthltlpve vsfysvsddn apspymtlfn pnktvvkmfv viydlrdmpa
      961 nhqtflrqrt fsvpvkqevk rsvnkenirh teerllryli hlrfqssksg kiylhrdvrl
     1021 lfsrksmevd sgaayelksy tesptnpqfs prc
//
LOCUS       XP_005254606             122 aa            linear   PRI 05-AUG-2025
DEFINITION  beta-2-microglobulin isoform X1 [Homo sapiens].
ACCESSION   XP_005254606
VERSION     XP_005254606.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254549.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..122
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..122
                     /product="beta-2-microglobulin isoform X1"
                     /calculated_mol_wt=13841
     Region          23..115
                     /region_name="IgC1_beta2m"
                     /note="Class I major histocompatibility complex (MHC)
                     beta-2-microglobulin; member of the C1-set of Ig
                     superfamily (IgSF) domains; cd05770"
                     /db_xref="CDD:409427"
     Region          24..31
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409427"
     Site            order(28,30..32,44,46,48,73..76,80,82..83)
                     /site_type="other"
                     /note="MHC classI alpha interface [polypeptide binding]"
                     /db_xref="CDD:409427"
     Site            order(28,32..34,41,46,53..54,73..77,79..80,83)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:409427"
     Region          41..48
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409427"
     Region          54..60
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409427"
     Region          63..65
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409427"
     Region          70..77
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409427"
     Region          82..90
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409427"
     Region          97..104
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409427"
     Region          111..115
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409427"
     CDS             1..122
                     /gene="B2M"
                     /gene_synonym="AMYLD6; IMD43; MHC1D4"
                     /coded_by="XM_005254549.4:31..399"
                     /db_xref="GeneID:567"
                     /db_xref="HGNC:HGNC:914"
                     /db_xref="MIM:109700"
ORIGIN      
        1 msrsvalavl allslsglea iqrtpkiqvy srhpaengks nflncyvsgf hpsdievdll
       61 kngeriekve hsdlsfskdw sfyllyytef tptekdeyac rvnhvtlsqp kivkwgksyi
      121 ll
//
LOCUS       XP_047288820            1047 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein C15orf39 isoform X1 [Homo sapiens].
ACCESSION   XP_047288820
VERSION     XP_047288820.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432864.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1047
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1047
                     /product="uncharacterized protein C15orf39 isoform X1"
                     /calculated_mol_wt=110542
     Region          1..1047
                     /region_name="DUF5525"
                     /note="Family of unknown function (DUF5525); pfam17663"
                     /db_xref="CDD:435956"
     CDS             1..1047
                     /gene="C15orf39"
                     /coded_by="XM_047432864.1:423..3566"
                     /db_xref="GeneID:56905"
                     /db_xref="HGNC:HGNC:24497"
                     /db_xref="MIM:621142"
ORIGIN      
        1 maekrplrtl gpvmygklpr letdsglehs lphsvgnqdp ctykgsyfsc pmagtpkaes
       61 eqlaswtpyp plystgmagp plqadnlltn clfyrspaeg pekmqdsspv ellpfspqah
      121 sypgpplaap kpvyrnplcy glstclgega vkrpldvdwt latgpllpsa dppcslapap
      181 skgqtldgtf lrgvpaegss kdssgsfspc qpflekyqti hstgflasry tgpyprnskq
      241 amsegpsspw tqlaqplgpp cqdtgpthyp pphhppphpp qalpcppacr hpekqgsysp
      301 alplqplggh kgtgyqaggl gspylrqqaa qapyipplgl daypypsapl papspglkle
      361 ppltprcpld fapqtlsfpy arddlslyga spglggtpps qnnvravpqp gafqracqpl
      421 pasqpcsepv rpaqeaeekt wlpscrkekl qprlsehsgp pivirdspvp ctppalppca
      481 recqslpqke garppssppm pvidnvfsla pyrdyldvpa peattepdsa taepdsapat
      541 segqdkgcrg tlpaqegpsg skplrgslke evaldlsvrk ptaeaspvka srsvehakpt
      601 aamdvpdvgn mvsdlpglkk idteapglpg vpvttdampr tnfhssvafm frkfkilrpa
      661 plpaavvpst ptsapaptqp aptptsgpig lrilaqqpls vtcfslalps ppavavaspa
      721 papapspapa raqapasard papapapvag papastsapg dsleqhftgl haslcdaisg
      781 svahsppekl rewletagpw gqaawqdcqg vqgllaklls qlqrfdrthr cpfphvvrag
      841 aifvpihlvk erlfprlppa svdhvlqehr velrpttlse eralrelalp gctsrmlkll
      901 alrqlpdiyp dllglqwrdc vrrqlgdfdt eagavsssep tvargepesl alaqkspapk
      961 vrkpgrkppt pgpekaeaaa geescgaspt patsasppgp tlkarfrsll etawlnglal
     1021 ptwghkssrp dqpspcpqll dsqshhl
//
LOCUS       XP_047288821             769 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein C15orf39 isoform X2 [Homo sapiens].
ACCESSION   XP_047288821
VERSION     XP_047288821.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432865.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..769
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..769
                     /product="uncharacterized protein C15orf39 isoform X2"
                     /calculated_mol_wt=81188
     Region          <72..769
                     /region_name="DUF5525"
                     /note="Family of unknown function (DUF5525); pfam17663"
                     /db_xref="CDD:435956"
     CDS             1..769
                     /gene="C15orf39"
                     /coded_by="XM_047432865.1:889..3198"
                     /db_xref="GeneID:56905"
                     /db_xref="HGNC:HGNC:24497"
                     /db_xref="MIM:621142"
ORIGIN      
        1 mltglwrlgp ccpqlthpal wpqllararl wmapscggcq lrgpvktpqg asphaspswr
       61 nirpstaras wppapspglk leppltprcp ldfapqtlsf pyarddlsly gaspglggtp
      121 psqnnvravp qpgafqracq plpasqpcse pvrpaqeaee ktwlpscrke klqprlsehs
      181 gppivirdsp vpctppalpp carecqslpq kegarppssp pmpvidnvfs lapyrdyldv
      241 papeattepd sataepdsap atsegqdkgc rgtlpaqegp sgskplrgsl keevaldlsv
      301 rkptaeaspv kasrsvehak ptaamdvpdv gnmvsdlpgl kkidteapgl pgvpvttdam
      361 prtnfhssva fmfrkfkilr paplpaavvp stptsapapt qpaptptsgp iglrilaqqp
      421 lsvtcfslal psppavavas papapapspa paraqapasa rdpapapapv agpapastsa
      481 pgdsleqhft glhaslcdai sgsvahsppe klrewletag pwgqaawqdc qgvqgllakl
      541 lsqlqrfdrt hrcpfphvvr agaifvpihl vkerlfprlp pasvdhvlqe hrvelrpttl
      601 seeralrela lpgctsrmlk llalrqlpdi ypdllglqwr dcvrrqlgdf dteagavsss
      661 eptvargepe slalaqkspa pkvrkpgrkp ptpgpekaea aageescgas ptpatsaspp
      721 gptlkarfrs lletawlngl alptwghkss rpdqpspcpq lldsqshhl
//
LOCUS       XP_006720677             725 aa            linear   PRI 05-AUG-2025
DEFINITION  WD repeat-containing protein 93 isoform X1 [Homo sapiens].
ACCESSION   XP_006720677
VERSION     XP_006720677.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720614.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..725
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..725
                     /product="WD repeat-containing protein 93 isoform X1"
                     /calculated_mol_wt=81771
     CDS             1..725
                     /gene="WDR93"
                     /gene_synonym="C1d-87; CFAP297; FAP297"
                     /coded_by="XM_006720614.2:88..2265"
                     /db_xref="GeneID:56964"
                     /db_xref="HGNC:HGNC:26924"
                     /db_xref="MIM:619891"
ORIGIN      
        1 msfprgsqtq kikhpigtrk gplevpppte kdwpkddeqd hvlvdpdeel dslpqpyrmi
       61 nklvnllfdq sweiieerna lreaessqiq ptvypplgei qlnkmpncma vsqdyvfigg
      121 akgfsiynly sakqiyawek lkvdvtsiwa tdlgneilia pvdemgiirl fyfykeglyl
      181 vkainevddt skqttcikme isqggdfaaf llqgagdiwl dvyklpketw lkklehpqlt
      241 snpkkkvrqp qlnslgpisa dplemdanvs fkgdiklslp vyimkikppk pvtgttfksp
      301 levfakikdc yglgsgqnhf ikdsqweqqa eifnasykky ldreweeepl statfyfllp
      361 sclfamppev kgpsgmacvl gihwtrshnf flyslnrtlk dkadpegvwp caapiavsql
      421 scsssylvla cedgvltlwd lakgfplgva alpqgcfcqs ihflkyfsvh kgqnmypegq
      481 vksqmkcvvl ctdaslhlve asgtqgptis vlvercssfp rmalcalwmw psvkssvplp
      541 lrepflwrsp gsqcllclqt ihvscseeti hmklrpptml esnilfsili lrpahswkis
      601 qkivpflkgt witwpspkhc hwrrdvsvss rraigswrrt qrrrrstgpg frgtpcrsre
      661 rtsrseaata lgslkrrfqp rgscsqdtea krnvtepqlh rpalgvwglc raskgksiiw
      721 gtfnh
//
LOCUS       XP_011520097             725 aa            linear   PRI 05-AUG-2025
DEFINITION  WD repeat-containing protein 93 isoform X1 [Homo sapiens].
ACCESSION   XP_011520097
VERSION     XP_011520097.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521795.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..725
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..725
                     /product="WD repeat-containing protein 93 isoform X1"
                     /calculated_mol_wt=81771
     CDS             1..725
                     /gene="WDR93"
                     /gene_synonym="C1d-87; CFAP297; FAP297"
                     /coded_by="XM_011521795.2:115..2292"
                     /db_xref="GeneID:56964"
                     /db_xref="HGNC:HGNC:26924"
                     /db_xref="MIM:619891"
ORIGIN      
        1 msfprgsqtq kikhpigtrk gplevpppte kdwpkddeqd hvlvdpdeel dslpqpyrmi
       61 nklvnllfdq sweiieerna lreaessqiq ptvypplgei qlnkmpncma vsqdyvfigg
      121 akgfsiynly sakqiyawek lkvdvtsiwa tdlgneilia pvdemgiirl fyfykeglyl
      181 vkainevddt skqttcikme isqggdfaaf llqgagdiwl dvyklpketw lkklehpqlt
      241 snpkkkvrqp qlnslgpisa dplemdanvs fkgdiklslp vyimkikppk pvtgttfksp
      301 levfakikdc yglgsgqnhf ikdsqweqqa eifnasykky ldreweeepl statfyfllp
      361 sclfamppev kgpsgmacvl gihwtrshnf flyslnrtlk dkadpegvwp caapiavsql
      421 scsssylvla cedgvltlwd lakgfplgva alpqgcfcqs ihflkyfsvh kgqnmypegq
      481 vksqmkcvvl ctdaslhlve asgtqgptis vlvercssfp rmalcalwmw psvkssvplp
      541 lrepflwrsp gsqcllclqt ihvscseeti hmklrpptml esnilfsili lrpahswkis
      601 qkivpflkgt witwpspkhc hwrrdvsvss rraigswrrt qrrrrstgpg frgtpcrsre
      661 rtsrseaata lgslkrrfqp rgscsqdtea krnvtepqlh rpalgvwglc raskgksiiw
      721 gtfnh
//
LOCUS       XP_011520096             725 aa            linear   PRI 05-AUG-2025
DEFINITION  WD repeat-containing protein 93 isoform X1 [Homo sapiens].
ACCESSION   XP_011520096
VERSION     XP_011520096.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521794.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..725
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..725
                     /product="WD repeat-containing protein 93 isoform X1"
                     /calculated_mol_wt=81771
     CDS             1..725
                     /gene="WDR93"
                     /gene_synonym="C1d-87; CFAP297; FAP297"
                     /coded_by="XM_011521794.3:107..2284"
                     /db_xref="GeneID:56964"
                     /db_xref="HGNC:HGNC:26924"
                     /db_xref="MIM:619891"
ORIGIN      
        1 msfprgsqtq kikhpigtrk gplevpppte kdwpkddeqd hvlvdpdeel dslpqpyrmi
       61 nklvnllfdq sweiieerna lreaessqiq ptvypplgei qlnkmpncma vsqdyvfigg
      121 akgfsiynly sakqiyawek lkvdvtsiwa tdlgneilia pvdemgiirl fyfykeglyl
      181 vkainevddt skqttcikme isqggdfaaf llqgagdiwl dvyklpketw lkklehpqlt
      241 snpkkkvrqp qlnslgpisa dplemdanvs fkgdiklslp vyimkikppk pvtgttfksp
      301 levfakikdc yglgsgqnhf ikdsqweqqa eifnasykky ldreweeepl statfyfllp
      361 sclfamppev kgpsgmacvl gihwtrshnf flyslnrtlk dkadpegvwp caapiavsql
      421 scsssylvla cedgvltlwd lakgfplgva alpqgcfcqs ihflkyfsvh kgqnmypegq
      481 vksqmkcvvl ctdaslhlve asgtqgptis vlvercssfp rmalcalwmw psvkssvplp
      541 lrepflwrsp gsqcllclqt ihvscseeti hmklrpptml esnilfsili lrpahswkis
      601 qkivpflkgt witwpspkhc hwrrdvsvss rraigswrrt qrrrrstgpg frgtpcrsre
      661 rtsrseaata lgslkrrfqp rgscsqdtea krnvtepqlh rpalgvwglc raskgksiiw
      721 gtfnh
//
LOCUS       XP_006720678             696 aa            linear   PRI 05-AUG-2025
DEFINITION  WD repeat-containing protein 93 isoform X2 [Homo sapiens].
ACCESSION   XP_006720678
VERSION     XP_006720678.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720615.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..696
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..696
                     /product="WD repeat-containing protein 93 isoform X2"
                     /calculated_mol_wt=78409
     CDS             1..696
                     /gene="WDR93"
                     /gene_synonym="C1d-87; CFAP297; FAP297"
                     /coded_by="XM_006720615.2:88..2178"
                     /db_xref="GeneID:56964"
                     /db_xref="HGNC:HGNC:26924"
                     /db_xref="MIM:619891"
ORIGIN      
        1 msfprgsqtq kikhpigtrk gplevpppte kdwpkddeqd hvlvdpdeel dslpqpyrmi
       61 nklvnllfdq sweiieerna lreaessqiq ptvypplgei qlnkmpncma vsqdyvfigg
      121 akgfsiynly sakqiyawek lkvdvtsiwa tdlgneilia pvdemgiirl fyfykeglyl
      181 vkainevddt skqttcikme isqggdfaaf llqgagdiwl dvyklpketw lkklehpqlt
      241 snpkkkvrqp qlnslgpisa dplemdanvs fkgdiklslp vyimkikppk pvtgttfksp
      301 levfakikdc yglgsgqnhf ikdsqweqqa eifnasykky ldreweeepl statfyfllp
      361 sclfamppev kgpsdpegvw pcaapiavsq lscsssylvl acedgvltlw dlakgfplgv
      421 aalpqgcfcq sihflkyfsv hkgqnmypeg qvksqmkcvv lctdaslhlv easgtqgpti
      481 svlvercssf prmalcalwm wpsvkssvpl plrepflwrs pgsqcllclq tihvscseet
      541 ihmklrpptm lesnilfsil ilrpahswki sqkivpflkg twitwpspkh chwrrdvsvs
      601 srraigswrr tqrrrrstgp gfrgtpcrsr ertsrseaat algslkrrfq prgscsqdte
      661 akrnvtepql hrpalgvwgl craskgksii wgtfnh
//
LOCUS       XP_011520098             640 aa            linear   PRI 05-AUG-2025
DEFINITION  WD repeat-containing protein 93 isoform X3 [Homo sapiens].
ACCESSION   XP_011520098
VERSION     XP_011520098.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521796.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..640
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..640
                     /product="WD repeat-containing protein 93 isoform X3"
                     /calculated_mol_wt=72414
     CDS             1..640
                     /gene="WDR93"
                     /gene_synonym="C1d-87; CFAP297; FAP297"
                     /coded_by="XM_011521796.3:88..2010"
                     /db_xref="GeneID:56964"
                     /db_xref="HGNC:HGNC:26924"
                     /db_xref="MIM:619891"
ORIGIN      
        1 msfprgsqtq kikhpigtrk gplevpppte kdwpkddeqd hvlvdpdeel dslpqpyrmi
       61 nklvnllfdq sweiieerna lreaessqiq ptvypplgei qlnkmpncma vsqdyvfigg
      121 akgfsiynly sakqiyawek lkvdvtsiwa tdlgneilia pvdemgiirl fyfykeglyl
      181 vkainevddt skqttcikme isqggdfaaf llqgagdiwl dvyklpketw lkklehpqlt
      241 snpkkkvrqp qlnslgpisa dplemdanvs fkgdiklslp vyimkikppk pvtgttfksp
      301 levfakikdc yglgsgqnhf ikdsqweqqa eifnasykky ldreweeepl statfyfllp
      361 sclfamppev kgpsgmacvl gihwtrshnf flyslnrtlk dkadpegvwp caapiavsql
      421 scsssylvla cedgvltlwd lakgfplgva alpqgcfcqs ihflkyfsvh kgqnmypegq
      481 vksqmkcvvl ctdaslhlve asgtqgptis vlvercssfp rmalcalwmw psvkssvplp
      541 lrepflwrsp gsqcllclqt ihvscseacp llenisknct ipqrdldnma fpqalplekr
      601 cerflqksyr kleknpekee ehwarlqrys lslqrenfkk
//
LOCUS       XP_047288824             549 aa            linear   PRI 05-AUG-2025
DEFINITION  WD repeat-containing protein 93 isoform X4 [Homo sapiens].
ACCESSION   XP_047288824
VERSION     XP_047288824.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432868.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..549
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..549
                     /product="WD repeat-containing protein 93 isoform X4"
                     /calculated_mol_wt=61809
     CDS             1..549
                     /gene="WDR93"
                     /gene_synonym="C1d-87; CFAP297; FAP297"
                     /coded_by="XM_047432868.1:95..1744"
                     /db_xref="GeneID:56964"
                     /db_xref="HGNC:HGNC:26924"
                     /db_xref="MIM:619891"
ORIGIN      
        1 mkyslllwmk wddtskqttc ikmeisqggd faafllqgag diwldvyklp ketwlkkleh
       61 pqltsnpkkk vrqpqlnslg pisadplemd anvsfkgdik lslpvyimki kppkpvtgtt
      121 fksplevfak ikdcyglgsg qnhfikdsqw eqqaeifnas ykkyldrewe eeplstatfy
      181 fllpsclfam ppevkgpsgm acvlgihwtr shnfflysln rtlkdkadpe gvwpcaapia
      241 vsqlscsssy lvlacedgvl tlwdlakgfp lgvaalpqgc fcqsihflky fsvhkgqnmy
      301 pegqvksqmk cvvlctdasl hlveasgtqg ptisvlverc ssfprmalca lwmwpsvkss
      361 vplplrepfl wrspgsqcll clqtihvscs eetihmklrp ptmlesnilf sililrpahs
      421 wkisqkivpf lkgtwitwps pkhchwrrdv svssrraigs wrrtqrrrrs tgpgfrgtpc
      481 rsrertsrse aatalgslkr rfqprgscsq dteakrnvte pqlhrpalgv wglcraskgk
      541 siiwgtfnh
//
LOCUS       XP_024305762             527 aa            linear   PRI 05-AUG-2025
DEFINITION  WD repeat-containing protein 93 isoform X5 [Homo sapiens].
ACCESSION   XP_024305762
VERSION     XP_024305762.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449994.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..527
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..527
                     /product="WD repeat-containing protein 93 isoform X5"
                     /calculated_mol_wt=59107
     CDS             1..527
                     /gene="WDR93"
                     /gene_synonym="C1d-87; CFAP297; FAP297"
                     /coded_by="XM_024449994.2:156..1739"
                     /db_xref="GeneID:56964"
                     /db_xref="HGNC:HGNC:26924"
                     /db_xref="MIM:619891"
ORIGIN      
        1 meisqggdfa afllqgagdi wldvyklpke twlkklehpq ltsnpkkkvr qpqlnslgpi
       61 sadplemdan vsfkgdikls lpvyimkikp pkpvtgttfk splevfakik dcyglgsgqn
      121 hfikdsqweq qaeifnasyk kyldreweee plstatfyfl lpsclfampp evkgpsgmac
      181 vlgihwtrsh nfflyslnrt lkdkadpegv wpcaapiavs qlscsssylv lacedgvltl
      241 wdlakgfplg vaalpqgcfc qsihflkyfs vhkgqnmype gqvksqmkcv vlctdaslhl
      301 veasgtqgpt isvlvercss fprmalcalw mwpsvkssvp lplrepflwr spgsqcllcl
      361 qtihvscsee tihmklrppt mlesnilfsi lilrpahswk isqkivpflk gtwitwpspk
      421 hchwrrdvsv ssrraigswr rtqrrrrstg pgfrgtpcrs rertsrseaa talgslkrrf
      481 qprgscsqdt eakrnvtepq lhrpalgvwg lcraskgksi iwgtfnh
//
LOCUS       XP_006720681             468 aa            linear   PRI 05-AUG-2025
DEFINITION  WD repeat-containing protein 93 isoform X6 [Homo sapiens].
ACCESSION   XP_006720681
VERSION     XP_006720681.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720618.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..468
                     /product="WD repeat-containing protein 93 isoform X6"
                     /calculated_mol_wt=52656
     CDS             1..468
                     /gene="WDR93"
                     /gene_synonym="C1d-87; CFAP297; FAP297"
                     /coded_by="XM_006720618.2:88..1494"
                     /db_xref="GeneID:56964"
                     /db_xref="HGNC:HGNC:26924"
                     /db_xref="MIM:619891"
ORIGIN      
        1 msfprgsqtq kikhpigtrk gplevpppte kdwpkddeqd hvlvdpdeel dslpqpyrmi
       61 nklvnllfdq sweiieerna lreaessqiq ptvypplgei qlnkmpncma vsqdyvfigg
      121 akgfsiynly sakqiyawek lkvdvtsiwa tdlgneilia pvdemgiirl fyfykeglyl
      181 vkainevddt skqttcikme isqggdfaaf llqgagdiwl dvyklpketw lkklehpqlt
      241 snpkkkvrqp qlnslgpisa dplemdanvs fkgdiklslp vyimkikppk pvtgttfksp
      301 levfakikdc yglgsgqnhf ikdsqweqqa eifnasykky ldreweeepl statfyfllp
      361 sclfamppev kgpsgmacvl gihwtrshnf flyslnrtlk dkadpegvwp caapiavsql
      421 scsssylvla cedgvltlwd lakvkkyvwh stsdhgglsl plpspqal
//
LOCUS       XP_047288825             372 aa            linear   PRI 05-AUG-2025
DEFINITION  WD repeat-containing protein 93 isoform X7 [Homo sapiens].
ACCESSION   XP_047288825
VERSION     XP_047288825.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432869.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..372
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..372
                     /product="WD repeat-containing protein 93 isoform X7"
                     /calculated_mol_wt=42176
     CDS             1..372
                     /gene="WDR93"
                     /gene_synonym="C1d-87; CFAP297; FAP297"
                     /coded_by="XM_047432869.1:88..1206"
                     /db_xref="GeneID:56964"
                     /db_xref="HGNC:HGNC:26924"
                     /db_xref="MIM:619891"
ORIGIN      
        1 msfprgsqtq kikhpigtrk gplevpppte kdwpkddeqd hvlvdpdeel dslpqpyrmi
       61 nklvnllfdq sweiieerna lreaessqiq ptvypplgei qlnkmpncma vsqdyvfigg
      121 akgfsiynly sakqiyawek lkvdvtsiwa tdlgneilia pvdemgiirl fyfykeglyl
      181 vkainevddt skqttcikme isqggdfaaf llqgagdiwl dvyklpketw lkklehpqlt
      241 snpkkkvrqp qlnslgpisa dplemdanvs fkgdiklslp vyimkikppk pvtgttfksp
      301 levfakikdc yglgsgqnhf ikdsqweqqa eifnasykky ldreweeepl sylkaqrlgt
      361 vaqacnpstl rv
//
LOCUS       XP_011520104             367 aa            linear   PRI 05-AUG-2025
DEFINITION  WD repeat-containing protein 93 isoform X8 [Homo sapiens].
ACCESSION   XP_011520104
VERSION     XP_011520104.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521802.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..367
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..367
                     /product="WD repeat-containing protein 93 isoform X8"
                     /calculated_mol_wt=41726
     CDS             1..367
                     /gene="WDR93"
                     /gene_synonym="C1d-87; CFAP297; FAP297"
                     /coded_by="XM_011521802.2:88..1191"
                     /db_xref="GeneID:56964"
                     /db_xref="HGNC:HGNC:26924"
                     /db_xref="MIM:619891"
ORIGIN      
        1 msfprgsqtq kikhpigtrk gplevpppte kdwpkddeqd hvlvdpdeel dslpqpyrmi
       61 nklvnllfdq sweiieerna lreaessqiq ptvypplgei qlnkmpncma vsqdyvfigg
      121 akgfsiynly sakqiyawek lkvdvtsiwa tdlgneilia pvdemgiirl fyfykeglyl
      181 vkainevddt skqttcikme isqggdfaaf llqgagdiwl dvyklpketw lkklehpqlt
      241 snpkkkvrqp qlnslgpisa dplemdanvs fkgdiklslp vyimkikppk pvtgttfksp
      301 levfakikdc yglgsgqnhf ikdsqweqqa eifnasykky ldreweeepl rtktlpaall
      361 arestwl
//
LOCUS       XP_047288827             173 aa            linear   PRI 05-AUG-2025
DEFINITION  WD repeat-containing protein 93 isoform X9 [Homo sapiens].
ACCESSION   XP_047288827
VERSION     XP_047288827.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432871.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..173
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..173
                     /product="WD repeat-containing protein 93 isoform X9"
                     /calculated_mol_wt=19575
     CDS             1..173
                     /gene="WDR93"
                     /gene_synonym="C1d-87; CFAP297; FAP297"
                     /coded_by="XM_047432871.1:115..636"
                     /db_xref="GeneID:56964"
                     /db_xref="HGNC:HGNC:26924"
                     /db_xref="MIM:619891"
ORIGIN      
        1 msfprgsqtq kikhpigtrk gplevpppte kdwpkddeqd hvlvdpdeel dslpqpyrmi
       61 nklvnllfdq sweiieerna lreaessqiq ptvypplgei qlnkmpncma vsqdyvfigg
      121 akgfsiynly sakqiyawek lkvdvtsiwa tdlgneilia pvdemgivlh lpf
//
LOCUS       XP_047288829             631 aa            linear   PRI 05-AUG-2025
DEFINITION  protein mono-ADP-ribosyltransferase PARP6 isoform X1 [Homo
            sapiens].
ACCESSION   XP_047288829
VERSION     XP_047288829.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432873.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..631
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..631
                     /product="protein mono-ADP-ribosyltransferase PARP6
                     isoform X1"
                     /calculated_mol_wt=71112
     Region          222..358
                     /region_name="ADP_ribosyl"
                     /note="ADP_ribosylating enzymes catalyze the transfer of
                     ADP_ribose from NAD+ to substrates. Bacterial toxins are
                     cytoplasmic and catalyze the transfer of a single
                     ADP_ribose unit to eukaryotic elongation factor 2, halting
                     protein synthesis and killing the cell; cd01341"
                     /db_xref="CDD:238651"
     Site            order(224..228,231,235,242..244,246,267..269,285,351)
                     /site_type="other"
                     /note="nad+ binding pocket [chemical binding]"
                     /db_xref="CDD:238651"
     Region          471..595
                     /region_name="ADP_ribosyl"
                     /note="ADP_ribosylating enzymes catalyze the transfer of
                     ADP_ribose from NAD+ to substrates. Bacterial toxins are
                     cytoplasmic and catalyze the transfer of a single
                     ADP_ribose unit to eukaryotic elongation factor 2, halting
                     protein synthesis and killing the cell; cd01341"
                     /db_xref="CDD:238651"
     Site            order(473..477,480,484,488..490,492,508..510,520,581)
                     /site_type="other"
                     /note="nad+ binding pocket [chemical binding]"
                     /db_xref="CDD:238651"
     CDS             1..631
                     /gene="PARP6"
                     /gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
                     /coded_by="XM_047432873.1:734..2629"
                     /db_xref="GeneID:56965"
                     /db_xref="HGNC:HGNC:26921"
                     /db_xref="MIM:619439"
ORIGIN      
        1 mdikgqfwnd ddsegdnese eflygvqgsc aadlyrhpql dadieavkei ysensvsire
       61 ygtiddvdid lhinisflde evstawkvlr tepivlrlrf slsqyldgpe psievfqpsn
      121 kegfglglql kkilgmftsq qwkhlsndfl ktqqekrhsw fkasgtikkf raglsifspi
      181 pkspsfpiiq dsmlkgklgv pelrvgrlmn rsisctmknp kvevfgypps pqagllcpqh
      241 vglppparts plvsghckni ptleygflvq imkyaeqrip tlneycvvcd eqhvfqngsm
      301 lkpavctrel cvfsfytlgv msgaaeevat gaevvdllva mcraalespr ksiifepyps
      361 vvdptdpktl afnpkkknye rlqkaldsvm siremtqgsy leikkqmdkl dplahpllqw
      421 iissnrshiv klplsrqlkf mhtshqflll ssppakearf rtakklygst fafhgshien
      481 whsilrnglv nasytklqlh gaaygkgiyl spissisfgy sgmgkgqhrm pskdelvqry
      541 nrmntipqtr siqsrflqsr nlncialcev itskdlqkhg niwvcpvsdh vctrfffvye
      601 dgqvgdanin tqdpkiqkei mrvigtqvyt n
//
LOCUS       XP_047288830             630 aa            linear   PRI 05-AUG-2025
DEFINITION  protein mono-ADP-ribosyltransferase PARP6 isoform X2 [Homo
            sapiens].
ACCESSION   XP_047288830
VERSION     XP_047288830.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432874.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..630
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..630
                     /product="protein mono-ADP-ribosyltransferase PARP6
                     isoform X2"
                     /calculated_mol_wt=70984
     Region          222..358
                     /region_name="ADP_ribosyl"
                     /note="ADP_ribosylating enzymes catalyze the transfer of
                     ADP_ribose from NAD+ to substrates. Bacterial toxins are
                     cytoplasmic and catalyze the transfer of a single
                     ADP_ribose unit to eukaryotic elongation factor 2, halting
                     protein synthesis and killing the cell; cd01341"
                     /db_xref="CDD:238651"
     Site            order(224..228,231,235,242..244,246,267..269,285,351)
                     /site_type="other"
                     /note="nad+ binding pocket [chemical binding]"
                     /db_xref="CDD:238651"
     Region          470..594
                     /region_name="ADP_ribosyl"
                     /note="ADP_ribosylating enzymes catalyze the transfer of
                     ADP_ribose from NAD+ to substrates. Bacterial toxins are
                     cytoplasmic and catalyze the transfer of a single
                     ADP_ribose unit to eukaryotic elongation factor 2, halting
                     protein synthesis and killing the cell; cd01341"
                     /db_xref="CDD:238651"
     Site            order(472..476,479,483,487..489,491,507..509,519,580)
                     /site_type="other"
                     /note="nad+ binding pocket [chemical binding]"
                     /db_xref="CDD:238651"
     CDS             1..630
                     /gene="PARP6"
                     /gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
                     /coded_by="XM_047432874.1:734..2626"
                     /db_xref="GeneID:56965"
                     /db_xref="HGNC:HGNC:26921"
                     /db_xref="MIM:619439"
ORIGIN      
        1 mdikgqfwnd ddsegdnese eflygvqgsc aadlyrhpql dadieavkei ysensvsire
       61 ygtiddvdid lhinisflde evstawkvlr tepivlrlrf slsqyldgpe psievfqpsn
      121 kegfglglql kkilgmftsq qwkhlsndfl ktqqekrhsw fkasgtikkf raglsifspi
      181 pkspsfpiiq dsmlkgklgv pelrvgrlmn rsisctmknp kvevfgypps pqagllcpqh
      241 vglppparts plvsghckni ptleygflvq imkyaeqrip tlneycvvcd eqhvfqngsm
      301 lkpavctrel cvfsfytlgv msgaaeevat gaevvdllva mcraalespr ksiifepyps
      361 vvdptdpktl afnpkkknye rlqkaldsvm siremtqgsy leikkqmdkl dplahpllqw
      421 iissnrshiv klplsrlkfm htshqfllls sppakearfr takklygstf afhgshienw
      481 hsilrnglvn asytklqlhg aaygkgiyls pissisfgys gmgkgqhrmp skdelvqryn
      541 rmntipqtrs iqsrflqsrn lncialcevi tskdlqkhgn iwvcpvsdhv ctrfffvyed
      601 gqvgdanint qdpkiqkeim rvigtqvytn
//
LOCUS       XP_047288831             519 aa            linear   PRI 05-AUG-2025
DEFINITION  protein mono-ADP-ribosyltransferase PARP6 isoform X3 [Homo
            sapiens].
ACCESSION   XP_047288831
VERSION     XP_047288831.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432875.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..519
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..519
                     /product="protein mono-ADP-ribosyltransferase PARP6
                     isoform X3"
                     /calculated_mol_wt=58480
     Region          222..358
                     /region_name="ADP_ribosyl"
                     /note="ADP_ribosylating enzymes catalyze the transfer of
                     ADP_ribose from NAD+ to substrates. Bacterial toxins are
                     cytoplasmic and catalyze the transfer of a single
                     ADP_ribose unit to eukaryotic elongation factor 2, halting
                     protein synthesis and killing the cell; cd01341"
                     /db_xref="CDD:238651"
     Site            order(224..228,231,235,242..244,246,267..269,285,351)
                     /site_type="other"
                     /note="nad+ binding pocket [chemical binding]"
                     /db_xref="CDD:238651"
     Region          471..>498
                     /region_name="ADP_ribosyl"
                     /note="ADP_ribosylating enzymes catalyze the transfer of
                     ADP_ribose from NAD+ to substrates. Bacterial toxins are
                     cytoplasmic and catalyze the transfer of a single
                     ADP_ribose unit to eukaryotic elongation factor 2, halting
                     protein synthesis and killing the cell; cl00283"
                     /db_xref="CDD:444809"
     CDS             1..519
                     /gene="PARP6"
                     /gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
                     /coded_by="XM_047432875.1:454..2013"
                     /db_xref="GeneID:56965"
                     /db_xref="HGNC:HGNC:26921"
                     /db_xref="MIM:619439"
ORIGIN      
        1 mdikgqfwnd ddsegdnese eflygvqgsc aadlyrhpql dadieavkei ysensvsire
       61 ygtiddvdid lhinisflde evstawkvlr tepivlrlrf slsqyldgpe psievfqpsn
      121 kegfglglql kkilgmftsq qwkhlsndfl ktqqekrhsw fkasgtikkf raglsifspi
      181 pkspsfpiiq dsmlkgklgv pelrvgrlmn rsisctmknp kvevfgypps pqagllcpqh
      241 vglppparts plvsghckni ptleygflvq imkyaeqrip tlneycvvcd eqhvfqngsm
      301 lkpavctrel cvfsfytlgv msgaaeevat gaevvdllva mcraalespr ksiifepyps
      361 vvdptdpktl afnpkkknye rlqkaldsvm siremtqgsy leikkqmdkl dplahpllqw
      421 iissnrshiv klplsrqlkf mhtshqflll ssppakearf rtakklygst fafhgshien
      481 whsilrnglv nasytklqew ekdstgcppr mswsrdttg
//
LOCUS       XP_047288832             518 aa            linear   PRI 05-AUG-2025
DEFINITION  protein mono-ADP-ribosyltransferase PARP6 isoform X4 [Homo
            sapiens].
ACCESSION   XP_047288832
VERSION     XP_047288832.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432876.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..518
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..518
                     /product="protein mono-ADP-ribosyltransferase PARP6
                     isoform X4"
                     /calculated_mol_wt=58352
     Region          222..358
                     /region_name="ADP_ribosyl"
                     /note="ADP_ribosylating enzymes catalyze the transfer of
                     ADP_ribose from NAD+ to substrates. Bacterial toxins are
                     cytoplasmic and catalyze the transfer of a single
                     ADP_ribose unit to eukaryotic elongation factor 2, halting
                     protein synthesis and killing the cell; cd01341"
                     /db_xref="CDD:238651"
     Site            order(224..228,231,235,242..244,246,267..269,285,351)
                     /site_type="other"
                     /note="nad+ binding pocket [chemical binding]"
                     /db_xref="CDD:238651"
     Region          470..>497
                     /region_name="ADP_ribosyl"
                     /note="ADP_ribosylating enzymes catalyze the transfer of
                     ADP_ribose from NAD+ to substrates. Bacterial toxins are
                     cytoplasmic and catalyze the transfer of a single
                     ADP_ribose unit to eukaryotic elongation factor 2, halting
                     protein synthesis and killing the cell; cl00283"
                     /db_xref="CDD:444809"
     CDS             1..518
                     /gene="PARP6"
                     /gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
                     /coded_by="XM_047432876.1:454..2010"
                     /db_xref="GeneID:56965"
                     /db_xref="HGNC:HGNC:26921"
                     /db_xref="MIM:619439"
ORIGIN      
        1 mdikgqfwnd ddsegdnese eflygvqgsc aadlyrhpql dadieavkei ysensvsire
       61 ygtiddvdid lhinisflde evstawkvlr tepivlrlrf slsqyldgpe psievfqpsn
      121 kegfglglql kkilgmftsq qwkhlsndfl ktqqekrhsw fkasgtikkf raglsifspi
      181 pkspsfpiiq dsmlkgklgv pelrvgrlmn rsisctmknp kvevfgypps pqagllcpqh
      241 vglppparts plvsghckni ptleygflvq imkyaeqrip tlneycvvcd eqhvfqngsm
      301 lkpavctrel cvfsfytlgv msgaaeevat gaevvdllva mcraalespr ksiifepyps
      361 vvdptdpktl afnpkkknye rlqkaldsvm siremtqgsy leikkqmdkl dplahpllqw
      421 iissnrshiv klplsrlkfm htshqfllls sppakearfr takklygstf afhgshienw
      481 hsilrnglvn asytklqewe kdstgcpprm swsrdttg
//
LOCUS       XP_047288833             498 aa            linear   PRI 05-AUG-2025
DEFINITION  protein mono-ADP-ribosyltransferase PARP6 isoform X5 [Homo
            sapiens].
ACCESSION   XP_047288833
VERSION     XP_047288833.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432877.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..498
                     /product="protein mono-ADP-ribosyltransferase PARP6
                     isoform X5"
                     /calculated_mol_wt=56346
     Region          225..338
                     /region_name="ADP_ribosyl"
                     /note="ADP_ribosylating enzymes catalyze the transfer of
                     ADP_ribose from NAD+ to substrates. Bacterial toxins are
                     cytoplasmic and catalyze the transfer of a single
                     ADP_ribose unit to eukaryotic elongation factor 2, halting
                     protein synthesis and killing the cell; cd01341"
                     /db_xref="CDD:238651"
     Region          450..>477
                     /region_name="ADP_ribosyl"
                     /note="ADP_ribosylating enzymes catalyze the transfer of
                     ADP_ribose from NAD+ to substrates. Bacterial toxins are
                     cytoplasmic and catalyze the transfer of a single
                     ADP_ribose unit to eukaryotic elongation factor 2, halting
                     protein synthesis and killing the cell; cl00283"
                     /db_xref="CDD:444809"
     CDS             1..498
                     /gene="PARP6"
                     /gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
                     /coded_by="XM_047432877.1:454..1950"
                     /db_xref="GeneID:56965"
                     /db_xref="HGNC:HGNC:26921"
                     /db_xref="MIM:619439"
ORIGIN      
        1 mdikgqfwnd ddsegdnese eflygvqgsc aadlyrhpql dadieavkei ysensvsire
       61 ygtiddvdid lhinisflde evstawkvlr tepivlrlrf slsqyldgpe psievfqpsn
      121 kegfglglql kkilgmftsq qwkhlsndfl ktqqekrhsw fkasgtikkf raglsifspi
      181 pkspsfpiiq dsmlkgklgv pelrvgrlmn rsisctmknp kvevfgypps pqvsghckni
      241 ptleygflvq imkyaeqrip tlneycvvcd eqhvfqngsm lkpavctrel cvfsfytlgv
      301 msgaaeevat gaevvdllva mcraalespr ksiifepyps vvdptdpktl afnpkkknye
      361 rlqkaldsvm siremtqgsy leikkqmdkl dplahpllqw iissnrshiv klplsrlkfm
      421 htshqfllls sppakearfr takklygstf afhgshienw hsilrnglvn asytklqewe
      481 kdstgcpprm swsrdttg
//
LOCUS       XP_011520107             496 aa            linear   PRI 05-AUG-2025
DEFINITION  protein mono-ADP-ribosyltransferase PARP6 isoform X6 [Homo
            sapiens].
ACCESSION   XP_011520107
VERSION     XP_011520107.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521805.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..496
                     /product="protein mono-ADP-ribosyltransferase PARP6
                     isoform X6"
                     /calculated_mol_wt=55842
     Region          87..223
                     /region_name="ADP_ribosyl"
                     /note="ADP_ribosylating enzymes catalyze the transfer of
                     ADP_ribose from NAD+ to substrates. Bacterial toxins are
                     cytoplasmic and catalyze the transfer of a single
                     ADP_ribose unit to eukaryotic elongation factor 2, halting
                     protein synthesis and killing the cell; cd01341"
                     /db_xref="CDD:238651"
     Site            order(89..93,96,100,107..109,111,132..134,150,216)
                     /site_type="other"
                     /note="nad+ binding pocket [chemical binding]"
                     /db_xref="CDD:238651"
     Region          336..460
                     /region_name="ADP_ribosyl"
                     /note="ADP_ribosylating enzymes catalyze the transfer of
                     ADP_ribose from NAD+ to substrates. Bacterial toxins are
                     cytoplasmic and catalyze the transfer of a single
                     ADP_ribose unit to eukaryotic elongation factor 2, halting
                     protein synthesis and killing the cell; cd01341"
                     /db_xref="CDD:238651"
     Site            order(338..342,345,349,353..355,357,373..375,385,446)
                     /site_type="other"
                     /note="nad+ binding pocket [chemical binding]"
                     /db_xref="CDD:238651"
     CDS             1..496
                     /gene="PARP6"
                     /gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
                     /coded_by="XM_011521805.3:305..1795"
                     /db_xref="GeneID:56965"
                     /db_xref="HGNC:HGNC:26921"
                     /db_xref="MIM:619439"
ORIGIN      
        1 mftsqqwkhl sndflktqqe krhswfkasg tikkfragls ifspipksps fpiiqdsmlk
       61 gklgvpelrv grlmnrsisc tmknpkvevf gyppspqagl lcpqhvglpp partsplvsg
      121 hckniptley gflvqimkya eqriptlney cvvcdeqhvf qngsmlkpav ctrelcvfsf
      181 ytlgvmsgaa eevatgaevv dllvamcraa lesprksiif epypsvvdpt dpktlafnpk
      241 kknyerlqka ldsvmsirem tqgsyleikk qmdkldplah pllqwiissn rshivklpls
      301 rqlkfmhtsh qflllssppa kearfrtakk lygstfafhg shienwhsil rnglvnasyt
      361 klqlhgaayg kgiylspiss isfgysgmgk gqhrmpskde lvqrynrmnt ipqtrsiqsr
      421 flqsrnlnci alcevitskd lqkhgniwvc pvsdhvctrf ffvyedgqvg danintqdpk
      481 iqkeimrvig tqvytn
//
LOCUS       XP_016877912             265 aa            linear   PRI 05-AUG-2025
DEFINITION  tRNA-uridine aminocarboxypropyltransferase 1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_016877912
VERSION     XP_016877912.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022423.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..265
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..265
                     /product="tRNA-uridine aminocarboxypropyltransferase 1
                     isoform X1"
                     /calculated_mol_wt=30044
     Region          66..>222
                     /region_name="DTW"
                     /note="DTW domain; pfam03942"
                     /db_xref="CDD:461101"
     CDS             1..265
                     /gene="DTWD1"
                     /gene_synonym="MDS009"
                     /coded_by="XM_017022423.3:131..928"
                     /db_xref="GeneID:56986"
                     /db_xref="HGNC:HGNC:30926"
                     /db_xref="MIM:621116"
ORIGIN      
        1 mslnppiflk rseensskfv etkqsqttsi asedplqnlc lasqevlqka qqsgrskclk
       61 cggsrmfycy tcyvpvenvp ieqiplvklp lkidiikhpn etdgkstaih akllapefvn
      121 iytypcipey eekdhevali fpgpqsisik disfhlqkri qnnvrgkndd pdkpsfkrkr
      181 teeqefcdln dskckgttlk kiifidstwn qtnkiftder lqvlsnfasg npsstswhgl
      241 iclfgatgkf tctfflsqtw nqlff
//
LOCUS       XP_047288835             265 aa            linear   PRI 05-AUG-2025
DEFINITION  tRNA-uridine aminocarboxypropyltransferase 1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_047288835
VERSION     XP_047288835.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432879.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..265
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..265
                     /product="tRNA-uridine aminocarboxypropyltransferase 1
                     isoform X1"
                     /calculated_mol_wt=30044
     Region          66..>222
                     /region_name="DTW"
                     /note="DTW domain; pfam03942"
                     /db_xref="CDD:461101"
     CDS             1..265
                     /gene="DTWD1"
                     /gene_synonym="MDS009"
                     /coded_by="XM_047432879.1:202..999"
                     /db_xref="GeneID:56986"
                     /db_xref="HGNC:HGNC:30926"
                     /db_xref="MIM:621116"
ORIGIN      
        1 mslnppiflk rseensskfv etkqsqttsi asedplqnlc lasqevlqka qqsgrskclk
       61 cggsrmfycy tcyvpvenvp ieqiplvklp lkidiikhpn etdgkstaih akllapefvn
      121 iytypcipey eekdhevali fpgpqsisik disfhlqkri qnnvrgkndd pdkpsfkrkr
      181 teeqefcdln dskckgttlk kiifidstwn qtnkiftder lqvlsnfasg npsstswhgl
      241 iclfgatgkf tctfflsqtw nqlff
//
LOCUS       XP_016877913             265 aa            linear   PRI 05-AUG-2025
DEFINITION  tRNA-uridine aminocarboxypropyltransferase 1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_016877913
VERSION     XP_016877913.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022424.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..265
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..265
                     /product="tRNA-uridine aminocarboxypropyltransferase 1
                     isoform X1"
                     /calculated_mol_wt=30044
     Region          66..>222
                     /region_name="DTW"
                     /note="DTW domain; pfam03942"
                     /db_xref="CDD:461101"
     CDS             1..265
                     /gene="DTWD1"
                     /gene_synonym="MDS009"
                     /coded_by="XM_017022424.2:259..1056"
                     /db_xref="GeneID:56986"
                     /db_xref="HGNC:HGNC:30926"
                     /db_xref="MIM:621116"
ORIGIN      
        1 mslnppiflk rseensskfv etkqsqttsi asedplqnlc lasqevlqka qqsgrskclk
       61 cggsrmfycy tcyvpvenvp ieqiplvklp lkidiikhpn etdgkstaih akllapefvn
      121 iytypcipey eekdhevali fpgpqsisik disfhlqkri qnnvrgkndd pdkpsfkrkr
      181 teeqefcdln dskckgttlk kiifidstwn qtnkiftder lqvlsnfasg npsstswhgl
      241 iclfgatgkf tctfflsqtw nqlff
//
LOCUS       XP_047288836             265 aa            linear   PRI 05-AUG-2025
DEFINITION  tRNA-uridine aminocarboxypropyltransferase 1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_047288836
VERSION     XP_047288836.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432880.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..265
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..265
                     /product="tRNA-uridine aminocarboxypropyltransferase 1
                     isoform X1"
                     /calculated_mol_wt=30044
     Region          66..>222
                     /region_name="DTW"
                     /note="DTW domain; pfam03942"
                     /db_xref="CDD:461101"
     CDS             1..265
                     /gene="DTWD1"
                     /gene_synonym="MDS009"
                     /coded_by="XM_047432880.1:1567..2364"
                     /db_xref="GeneID:56986"
                     /db_xref="HGNC:HGNC:30926"
                     /db_xref="MIM:621116"
ORIGIN      
        1 mslnppiflk rseensskfv etkqsqttsi asedplqnlc lasqevlqka qqsgrskclk
       61 cggsrmfycy tcyvpvenvp ieqiplvklp lkidiikhpn etdgkstaih akllapefvn
      121 iytypcipey eekdhevali fpgpqsisik disfhlqkri qnnvrgkndd pdkpsfkrkr
      181 teeqefcdln dskckgttlk kiifidstwn qtnkiftder lqvlsnfasg npsstswhgl
      241 iclfgatgkf tctfflsqtw nqlff
//
LOCUS       XP_011520117             226 aa            linear   PRI 05-AUG-2025
DEFINITION  tRNA-uridine aminocarboxypropyltransferase 1 isoform X2 [Homo
            sapiens].
ACCESSION   XP_011520117
VERSION     XP_011520117.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521815.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..226
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..226
                     /product="tRNA-uridine aminocarboxypropyltransferase 1
                     isoform X2"
                     /calculated_mol_wt=25813
     Region          66..>222
                     /region_name="DTW"
                     /note="DTW domain; pfam03942"
                     /db_xref="CDD:461101"
     CDS             1..226
                     /gene="DTWD1"
                     /gene_synonym="MDS009"
                     /coded_by="XM_011521815.3:131..811"
                     /db_xref="GeneID:56986"
                     /db_xref="HGNC:HGNC:30926"
                     /db_xref="MIM:621116"
ORIGIN      
        1 mslnppiflk rseensskfv etkqsqttsi asedplqnlc lasqevlqka qqsgrskclk
       61 cggsrmfycy tcyvpvenvp ieqiplvklp lkidiikhpn etdgkstaih akllapefvn
      121 iytypcipey eekdhevali fpgpqsisik disfhlqkri qnnvrgkndd pdkpsfkrkr
      181 teeqefcdln dskckgttlk kiifidstwn qtnkiftder lqekek
//
LOCUS       XP_047288837             226 aa            linear   PRI 05-AUG-2025
DEFINITION  tRNA-uridine aminocarboxypropyltransferase 1 isoform X2 [Homo
            sapiens].
ACCESSION   XP_047288837
VERSION     XP_047288837.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432881.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..226
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..226
                     /product="tRNA-uridine aminocarboxypropyltransferase 1
                     isoform X2"
                     /calculated_mol_wt=25813
     Region          66..>222
                     /region_name="DTW"
                     /note="DTW domain; pfam03942"
                     /db_xref="CDD:461101"
     CDS             1..226
                     /gene="DTWD1"
                     /gene_synonym="MDS009"
                     /coded_by="XM_047432881.1:202..882"
                     /db_xref="GeneID:56986"
                     /db_xref="HGNC:HGNC:30926"
                     /db_xref="MIM:621116"
ORIGIN      
        1 mslnppiflk rseensskfv etkqsqttsi asedplqnlc lasqevlqka qqsgrskclk
       61 cggsrmfycy tcyvpvenvp ieqiplvklp lkidiikhpn etdgkstaih akllapefvn
      121 iytypcipey eekdhevali fpgpqsisik disfhlqkri qnnvrgkndd pdkpsfkrkr
      181 teeqefcdln dskckgttlk kiifidstwn qtnkiftder lqekek
//
LOCUS       XP_016877914             226 aa            linear   PRI 05-AUG-2025
DEFINITION  tRNA-uridine aminocarboxypropyltransferase 1 isoform X2 [Homo
            sapiens].
ACCESSION   XP_016877914
VERSION     XP_016877914.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022425.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..226
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..226
                     /product="tRNA-uridine aminocarboxypropyltransferase 1
                     isoform X2"
                     /calculated_mol_wt=25813
     Region          66..>222
                     /region_name="DTW"
                     /note="DTW domain; pfam03942"
                     /db_xref="CDD:461101"
     CDS             1..226
                     /gene="DTWD1"
                     /gene_synonym="MDS009"
                     /coded_by="XM_017022425.2:259..939"
                     /db_xref="GeneID:56986"
                     /db_xref="HGNC:HGNC:30926"
                     /db_xref="MIM:621116"
ORIGIN      
        1 mslnppiflk rseensskfv etkqsqttsi asedplqnlc lasqevlqka qqsgrskclk
       61 cggsrmfycy tcyvpvenvp ieqiplvklp lkidiikhpn etdgkstaih akllapefvn
      121 iytypcipey eekdhevali fpgpqsisik disfhlqkri qnnvrgkndd pdkpsfkrkr
      181 teeqefcdln dskckgttlk kiifidstwn qtnkiftder lqekek
//
LOCUS       XP_016877915             226 aa            linear   PRI 05-AUG-2025
DEFINITION  tRNA-uridine aminocarboxypropyltransferase 1 isoform X2 [Homo
            sapiens].
ACCESSION   XP_016877915
VERSION     XP_016877915.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022426.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..226
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..226
                     /product="tRNA-uridine aminocarboxypropyltransferase 1
                     isoform X2"
                     /calculated_mol_wt=25813
     Region          66..>222
                     /region_name="DTW"
                     /note="DTW domain; pfam03942"
                     /db_xref="CDD:461101"
     CDS             1..226
                     /gene="DTWD1"
                     /gene_synonym="MDS009"
                     /coded_by="XM_017022426.2:1439..2119"
                     /db_xref="GeneID:56986"
                     /db_xref="HGNC:HGNC:30926"
                     /db_xref="MIM:621116"
ORIGIN      
        1 mslnppiflk rseensskfv etkqsqttsi asedplqnlc lasqevlqka qqsgrskclk
       61 cggsrmfycy tcyvpvenvp ieqiplvklp lkidiikhpn etdgkstaih akllapefvn
      121 iytypcipey eekdhevali fpgpqsisik disfhlqkri qnnvrgkndd pdkpsfkrkr
      181 teeqefcdln dskckgttlk kiifidstwn qtnkiftder lqekek
//
LOCUS       XP_011520120             297 aa            linear   PRI 05-AUG-2025
DEFINITION  cell death regulator Aven isoform X1 [Homo sapiens].
ACCESSION   XP_011520120
VERSION     XP_011520120.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521818.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..297
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..297
                     /product="cell death regulator Aven isoform X1"
                     /calculated_mol_wt=32706
     CDS             1..297
                     /gene="AVEN"
                     /gene_synonym="PDCD12"
                     /coded_by="XM_011521818.3:484..1377"
                     /db_xref="GeneID:57099"
                     /db_xref="HGNC:HGNC:13509"
                     /db_xref="MIM:605265"
ORIGIN      
        1 mkwthilssm essstlypsd hfikveddsd aetygeende qgnyskrkiv snwdryqdie
       61 kevnnesges qrgtdfsvll ssagdsfsqf rfaeekewds eascpkqnsa fyvdsellvr
      121 alqelplclr lnvaaelvqg tvplevpqvk pkrtddgkgl gmqlkgplgp ggrgpifelk
      181 svaagcpvll gkdnpspgps rdsqkptspl qsagdhleee ldlllnldap ikegdnilpd
      241 qtsqdlkske dgevvqeeev cakpsvteek nmepeqpsts knvteeeled wldsmis
//
LOCUS       XP_047288838             297 aa            linear   PRI 05-AUG-2025
DEFINITION  cell death regulator Aven isoform X1 [Homo sapiens].
ACCESSION   XP_047288838
VERSION     XP_047288838.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432882.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..297
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..297
                     /product="cell death regulator Aven isoform X1"
                     /calculated_mol_wt=32706
     CDS             1..297
                     /gene="AVEN"
                     /gene_synonym="PDCD12"
                     /coded_by="XM_047432882.1:272..1165"
                     /db_xref="GeneID:57099"
                     /db_xref="HGNC:HGNC:13509"
                     /db_xref="MIM:605265"
ORIGIN      
        1 mkwthilssm essstlypsd hfikveddsd aetygeende qgnyskrkiv snwdryqdie
       61 kevnnesges qrgtdfsvll ssagdsfsqf rfaeekewds eascpkqnsa fyvdsellvr
      121 alqelplclr lnvaaelvqg tvplevpqvk pkrtddgkgl gmqlkgplgp ggrgpifelk
      181 svaagcpvll gkdnpspgps rdsqkptspl qsagdhleee ldlllnldap ikegdnilpd
      241 qtsqdlkske dgevvqeeev cakpsvteek nmepeqpsts knvteeeled wldsmis
//
LOCUS       XP_024305767             287 aa            linear   PRI 05-AUG-2025
DEFINITION  cell death regulator Aven isoform X2 [Homo sapiens].
ACCESSION   XP_024305767
VERSION     XP_024305767.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024449999.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..287
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..287
                     /product="cell death regulator Aven isoform X2"
                     /calculated_mol_wt=31529
     CDS             1..287
                     /gene="AVEN"
                     /gene_synonym="PDCD12"
                     /coded_by="XM_024449999.2:192..1055"
                     /db_xref="GeneID:57099"
                     /db_xref="HGNC:HGNC:13509"
                     /db_xref="MIM:605265"
ORIGIN      
        1 mmlfsgrlkl shtqveddsd aetygeende qgnyskrkiv snwdryqdie kevnnesges
       61 qrgtdfsvll ssagdsfsqf rfaeekewds eascpkqnsa fyvdsellvr alqelplclr
      121 lnvaaelvqg tvplevpqvk pkrtddgkgl gmqlkgplgp ggrgpifelk svaagcpvll
      181 gkdnpspgps rdsqkptspl qsagdhleee ldlllnldap ikegdnilpd qtsqdlkske
      241 dgevvqeeev cakpsvteek nmepeqpsts knvteeeled wldsmis
//
LOCUS       XP_011520122             276 aa            linear   PRI 05-AUG-2025
DEFINITION  cell death regulator Aven isoform X3 [Homo sapiens].
ACCESSION   XP_011520122
VERSION     XP_011520122.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521820.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..276
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..276
                     /product="cell death regulator Aven isoform X3"
                     /calculated_mol_wt=30242
     CDS             1..276
                     /gene="AVEN"
                     /gene_synonym="PDCD12"
                     /coded_by="XM_011521820.1:16..846"
                     /db_xref="GeneID:57099"
                     /db_xref="HGNC:HGNC:13509"
                     /db_xref="MIM:605265"
ORIGIN      
        1 mrgveddsda etygeendeq gnyskrkivs nwdryqdiek evnnesgesq rgtdfsvlls
       61 sagdsfsqfr faeekewdse ascpkqnsaf yvdsellvra lqelplclrl nvaaelvqgt
      121 vplevpqvkp krtddgkglg mqlkgplgpg grgpifelks vaagcpvllg kdnpspgpsr
      181 dsqkptsplq sagdhleeel dlllnldapi kegdnilpdq tsqdlksked gevvqeeevc
      241 akpsvteekn mepeqpstsk nvteeeledw ldsmis
//
LOCUS       XP_047288839             198 aa            linear   PRI 05-AUG-2025
DEFINITION  protein FAM219B isoform X1 [Homo sapiens].
ACCESSION   XP_047288839
VERSION     XP_047288839.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432883.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..198
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..198
                     /product="protein FAM219B isoform X1"
                     /calculated_mol_wt=20971
     Region          72..198
                     /region_name="FAM219A"
                     /note="Protein family FAM219A; pfam15260"
                     /db_xref="CDD:464600"
     CDS             1..198
                     /gene="FAM219B"
                     /gene_synonym="C15orf17"
                     /coded_by="XM_047432883.1:52..648"
                     /db_xref="GeneID:57184"
                     /db_xref="HGNC:HGNC:24695"
ORIGIN      
        1 mataepsgra lrlstpgprp sgardrapga agppsgqign ralrlgertp aavekrgpym
       61 vtrapsiqak lqkhrdlaka vlrrkgmlga spnrpdssgk rsvkfnkgyt alsqspdenl
      121 vsldsdsdge lgsryssgys saeqvnqdvs rqllqdgyhl deipddedld lippkpmass
      181 tcsccwcclg dsssctlq
//
LOCUS       XP_047288840             197 aa            linear   PRI 05-AUG-2025
DEFINITION  protein FAM219B isoform X2 [Homo sapiens].
ACCESSION   XP_047288840
VERSION     XP_047288840.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432884.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..197
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..197
                     /product="protein FAM219B isoform X2"
                     /calculated_mol_wt=20843
     Region          72..197
                     /region_name="FAM219A"
                     /note="Protein family FAM219A; pfam15260"
                     /db_xref="CDD:464600"
     CDS             1..197
                     /gene="FAM219B"
                     /gene_synonym="C15orf17"
                     /coded_by="XM_047432884.1:52..645"
                     /db_xref="GeneID:57184"
                     /db_xref="HGNC:HGNC:24695"
ORIGIN      
        1 mataepsgra lrlstpgprp sgardrapga agppsgqign ralrlgertp aavekrgpym
       61 vtrapsiqak lqkhrdlaka vlrrkgmlga spnrpdssgk rsvkfnkgyt alsqspdenl
      121 vsldsdsdge lgsryssgys saevnqdvsr qllqdgyhld eipddedldl ippkpmasst
      181 csccwcclgd sssctlq
//
LOCUS       XP_016877922             197 aa            linear   PRI 05-AUG-2025
DEFINITION  protein FAM219B isoform X2 [Homo sapiens].
ACCESSION   XP_016877922
VERSION     XP_016877922.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022433.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..197
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..197
                     /product="protein FAM219B isoform X2"
                     /calculated_mol_wt=20843
     Region          72..197
                     /region_name="FAM219A"
                     /note="Protein family FAM219A; pfam15260"
                     /db_xref="CDD:464600"
     CDS             1..197
                     /gene="FAM219B"
                     /gene_synonym="C15orf17"
                     /coded_by="XM_017022433.3:52..645"
                     /db_xref="GeneID:57184"
                     /db_xref="HGNC:HGNC:24695"
ORIGIN      
        1 mataepsgra lrlstpgprp sgardrapga agppsgqign ralrlgertp aavekrgpym
       61 vtrapsiqak lqkhrdlaka vlrrkgmlga spnrpdssgk rsvkfnkgyt alsqspdenl
      121 vsldsdsdge lgsryssgys saevnqdvsr qllqdgyhld eipddedldl ippkpmasst
      181 csccwcclgd sssctlq
//
LOCUS       XP_011520124            1718 aa            linear   PRI 05-AUG-2025
DEFINITION  ADAMTS-like protein 3 isoform X1 [Homo sapiens].
ACCESSION   XP_011520124
VERSION     XP_011520124.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521822.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1718
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1718
                     /product="ADAMTS-like protein 3 isoform X1"
                     /calculated_mol_wt=191198
     Region          78..124
                     /region_name="TSP1"
                     /note="Thrombospondin type 1 repeats; smart00209"
                     /db_xref="CDD:214559"
     Region          129..227
                     /region_name="ADAMTS_CR_3"
                     /note="ADAMTS cysteine-rich domain; pfam19236"
                     /db_xref="CDD:437068"
     Region          370..428
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          449..506
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          509..561
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          597..652
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          675..730
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          734..786
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          790..846
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          852..907
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          <956..1020
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          957..961
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          970..974
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          992..996
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          1006..1011
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          1015..1018
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          1238..1303
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cd00096"
                     /db_xref="CDD:409353"
     Region          1238..1242
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          1251..1255
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          1273..1277
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          1287..1292
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          1320..1410
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          1344..1348
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          1357..1361
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          1377..1381
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          1391..1396
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          1404..1407
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          1455..1510
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          1514..1571
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          1628..1682
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          1686..1716
                     /region_name="PLAC"
                     /note="PLAC (protease and lacunin) domain; pfam08686"
                     /db_xref="CDD:462560"
     CDS             1..1718
                     /gene="ADAMTSL3"
                     /gene_synonym="ADAMTSL-3"
                     /coded_by="XM_011521822.3:188..5344"
                     /db_xref="GeneID:57188"
                     /db_xref="HGNC:HGNC:14633"
                     /db_xref="MIM:609199"
ORIGIN      
        1 maswtspwwv ligmvfmhsp lpqttaeksp gayflpefal spqgsfledt tgeqfltyry
       61 ddqtsrntrs dedkdgnwda wgdwsdcsrt cgggasyslr rcltgrnceg qniryktcsn
      121 hdcppdaedf raqqcsaynd vqyqghyyew lpryndpaap calkchaqgq nlvvelapkv
      181 ldgtrcntds ldmcisgicq avgcdrqlgs nakedncgvc agdgstcrlv rgqskshvsp
      241 ektpglppgq ggplpgghls aiyewpilkg eenviavplg srsvritvkg pahlfieskt
      301 lqgskgehsf nspgvflven ttvefqrgse rqtfkipgpl madfifktry taakdsvvqf
      361 ffyqpishqw rqtdffpctv tcgggyqlns aecvdirlkr vvpdhychyy penvkpkpkl
      421 kecsmdpcps sdgfkeimpy dhfqplprwe hnpwtacsvs cgggiqrrsf vcveesmhge
      481 ilqveewkcm yapkpkvmqt cnlfdcpkwi amewsqctvt cgrglryrvv lcinhrgehv
      541 ggcnpqlklh ikeecvipip cykpkekspv eaklpwlkqa qeleetriat eeptfipepw
      601 sacsttcgpg vqvrevkcrv lltftqtete lpeeecegpk lpterpclle acdespasre
      661 ldiplpedse ttydweyagf tpctatcvgg hqeaiavclh iqtqqtvnds lcdmvhrppa
      721 msqacntepc pprwhvgswg pcsatcgvgi qtrdvyclhp getpappeec rdekphalqa
      781 cnqfdcppgw hieewqqcsr tcgggtqnrr vtcrqlltdg sflnlsdelc qgpkasshks
      841 cartdcpphl avgdwskcsv scgvgiqrrk qvcqrlaakg rriplsemmc rdlpglplvr
      901 scqmpecski ksemktklge qgpqilsvqr vyiqtreekr inltigsray llpntsviik
      961 cpvrrfqksl iqwekdgrcl qnskrlgitk sgslkihgla apdigvyrci agsaqetvvl
     1021 kligtdnrli arpalrepmr eypgmdhsea nslgvtwhkm rqmwnnkndl yldddhisnq
     1081 pflrallghc snsagstnsw elknkqfeaa vkqgaysmdt aqfdelirnm sqlmetgevs
     1141 ddlasqliyq lvaelakaqp thmqwrgiqe etppaaqlrg etgsvsqssh aknsgkltfk
     1201 pkgpvlmrqs qppsisfnkt insrigntvy itkrtevini lcdlitpsea tytwtkdgtl
     1261 lqpsvkiild gtgkiqiqnp trkeqgiyec svanhlgsdv esssvlyaea pvilsverni
     1321 tkpehnhlsv vvggiveaal ganvtircpv kgvpqpnitw lkrggslsgn vsllfngsll
     1381 lqnvsleneg tyvciatnal gkavatsvlh llerrwpesr ivflqghkky ilqatntrtn
     1441 sndptgeppp qepfwepgnw shcsatcghl gariqrpqcv mangqevsea lcdhlqkpla
     1501 gfepcnirdc parwftsvws qcsvscgegy hsrqvtckrt kangtvqvvs pracapkdrp
     1561 lgrkpcfghp cvqwepgnrc pgrcmgravr mqqrhtacqh nssdsncddr krptlrrnct
     1621 sgacdvcwht gpwkpctaac grgfqsrkvd cihtrsckpv akrhcvqkkk piswrhclgp
     1681 scdrdctdtt hycmfvkhln lcsldrykqr ccqscqeg
//
LOCUS       XP_016877923            1709 aa            linear   PRI 05-AUG-2025
DEFINITION  ADAMTS-like protein 3 isoform X2 [Homo sapiens].
ACCESSION   XP_016877923
VERSION     XP_016877923.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022434.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1709
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1709
                     /product="ADAMTS-like protein 3 isoform X2"
                     /calculated_mol_wt=189746
     Region          78..124
                     /region_name="TSP1"
                     /note="Thrombospondin type 1 repeats; smart00209"
                     /db_xref="CDD:214559"
     Region          129..227
                     /region_name="ADAMTS_CR_3"
                     /note="ADAMTS cysteine-rich domain; pfam19236"
                     /db_xref="CDD:437068"
     Region          370..428
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          449..506
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          509..561
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          597..652
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          675..730
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          734..786
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          790..846
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          852..907
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          <956..1020
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          957..961
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          970..974
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          992..996
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          1006..1011
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          1015..1018
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          1238..1303
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cd00096"
                     /db_xref="CDD:409353"
     Region          1238..1242
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          1251..1255
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          1273..1277
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          1287..1292
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          1320..1410
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          1344..1348
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          1357..1361
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          1377..1381
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          1391..1396
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          1404..1407
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          1455..1510
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          1514..1571
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          1628..1682
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     CDS             1..1709
                     /gene="ADAMTSL3"
                     /gene_synonym="ADAMTSL-3"
                     /coded_by="XM_017022434.2:188..5317"
                     /db_xref="GeneID:57188"
                     /db_xref="HGNC:HGNC:14633"
                     /db_xref="MIM:609199"
ORIGIN      
        1 maswtspwwv ligmvfmhsp lpqttaeksp gayflpefal spqgsfledt tgeqfltyry
       61 ddqtsrntrs dedkdgnwda wgdwsdcsrt cgggasyslr rcltgrnceg qniryktcsn
      121 hdcppdaedf raqqcsaynd vqyqghyyew lpryndpaap calkchaqgq nlvvelapkv
      181 ldgtrcntds ldmcisgicq avgcdrqlgs nakedncgvc agdgstcrlv rgqskshvsp
      241 ektpglppgq ggplpgghls aiyewpilkg eenviavplg srsvritvkg pahlfieskt
      301 lqgskgehsf nspgvflven ttvefqrgse rqtfkipgpl madfifktry taakdsvvqf
      361 ffyqpishqw rqtdffpctv tcgggyqlns aecvdirlkr vvpdhychyy penvkpkpkl
      421 kecsmdpcps sdgfkeimpy dhfqplprwe hnpwtacsvs cgggiqrrsf vcveesmhge
      481 ilqveewkcm yapkpkvmqt cnlfdcpkwi amewsqctvt cgrglryrvv lcinhrgehv
      541 ggcnpqlklh ikeecvipip cykpkekspv eaklpwlkqa qeleetriat eeptfipepw
      601 sacsttcgpg vqvrevkcrv lltftqtete lpeeecegpk lpterpclle acdespasre
      661 ldiplpedse ttydweyagf tpctatcvgg hqeaiavclh iqtqqtvnds lcdmvhrppa
      721 msqacntepc pprwhvgswg pcsatcgvgi qtrdvyclhp getpappeec rdekphalqa
      781 cnqfdcppgw hieewqqcsr tcgggtqnrr vtcrqlltdg sflnlsdelc qgpkasshks
      841 cartdcpphl avgdwskcsv scgvgiqrrk qvcqrlaakg rriplsemmc rdlpglplvr
      901 scqmpecski ksemktklge qgpqilsvqr vyiqtreekr inltigsray llpntsviik
      961 cpvrrfqksl iqwekdgrcl qnskrlgitk sgslkihgla apdigvyrci agsaqetvvl
     1021 kligtdnrli arpalrepmr eypgmdhsea nslgvtwhkm rqmwnnkndl yldddhisnq
     1081 pflrallghc snsagstnsw elknkqfeaa vkqgaysmdt aqfdelirnm sqlmetgevs
     1141 ddlasqliyq lvaelakaqp thmqwrgiqe etppaaqlrg etgsvsqssh aknsgkltfk
     1201 pkgpvlmrqs qppsisfnkt insrigntvy itkrtevini lcdlitpsea tytwtkdgtl
     1261 lqpsvkiild gtgkiqiqnp trkeqgiyec svanhlgsdv esssvlyaea pvilsverni
     1321 tkpehnhlsv vvggiveaal ganvtircpv kgvpqpnitw lkrggslsgn vsllfngsll
     1381 lqnvsleneg tyvciatnal gkavatsvlh llerrwpesr ivflqghkky ilqatntrtn
     1441 sndptgeppp qepfwepgnw shcsatcghl gariqrpqcv mangqevsea lcdhlqkpla
     1501 gfepcnirdc parwftsvws qcsvscgegy hsrqvtckrt kangtvqvvs pracapkdrp
     1561 lgrkpcfghp cvqwepgnrc pgrcmgravr mqqrhtacqh nssdsncddr krptlrrnct
     1621 sgacdvcwht gpwkpctaac grgfqsrkvd cihtrsckpv akrhcvqkkk piswrhclgp
     1681 scdstytsqt atnkgaashv krdkplegs
//
LOCUS       XP_011520125            1701 aa            linear   PRI 05-AUG-2025
DEFINITION  ADAMTS-like protein 3 isoform X3 [Homo sapiens].
ACCESSION   XP_011520125
VERSION     XP_011520125.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521823.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1701
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1701
                     /product="ADAMTS-like protein 3 isoform X3"
                     /calculated_mol_wt=188986
     Region          78..124
                     /region_name="TSP1"
                     /note="Thrombospondin type 1 repeats; smart00209"
                     /db_xref="CDD:214559"
     Region          129..227
                     /region_name="ADAMTS_CR_3"
                     /note="ADAMTS cysteine-rich domain; pfam19236"
                     /db_xref="CDD:437068"
     Region          370..428
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          449..506
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          509..561
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          597..652
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          675..730
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          734..786
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          790..846
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          852..907
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          <956..1020
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          957..961
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          970..974
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          992..996
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          1006..1011
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          1015..1018
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          1238..1303
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cd00096"
                     /db_xref="CDD:409353"
     Region          1238..1242
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          1251..1255
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          1273..1277
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          1287..1292
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          1320..1410
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          1344..1348
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          1357..1361
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          1377..1381
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          1391..1396
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          1404..1407
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          1455..1510
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          1514..1571
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          1628..1682
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     CDS             1..1701
                     /gene="ADAMTSL3"
                     /gene_synonym="ADAMTSL-3"
                     /coded_by="XM_011521823.3:188..5293"
                     /db_xref="GeneID:57188"
                     /db_xref="HGNC:HGNC:14633"
                     /db_xref="MIM:609199"
ORIGIN      
        1 maswtspwwv ligmvfmhsp lpqttaeksp gayflpefal spqgsfledt tgeqfltyry
       61 ddqtsrntrs dedkdgnwda wgdwsdcsrt cgggasyslr rcltgrnceg qniryktcsn
      121 hdcppdaedf raqqcsaynd vqyqghyyew lpryndpaap calkchaqgq nlvvelapkv
      181 ldgtrcntds ldmcisgicq avgcdrqlgs nakedncgvc agdgstcrlv rgqskshvsp
      241 ektpglppgq ggplpgghls aiyewpilkg eenviavplg srsvritvkg pahlfieskt
      301 lqgskgehsf nspgvflven ttvefqrgse rqtfkipgpl madfifktry taakdsvvqf
      361 ffyqpishqw rqtdffpctv tcgggyqlns aecvdirlkr vvpdhychyy penvkpkpkl
      421 kecsmdpcps sdgfkeimpy dhfqplprwe hnpwtacsvs cgggiqrrsf vcveesmhge
      481 ilqveewkcm yapkpkvmqt cnlfdcpkwi amewsqctvt cgrglryrvv lcinhrgehv
      541 ggcnpqlklh ikeecvipip cykpkekspv eaklpwlkqa qeleetriat eeptfipepw
      601 sacsttcgpg vqvrevkcrv lltftqtete lpeeecegpk lpterpclle acdespasre
      661 ldiplpedse ttydweyagf tpctatcvgg hqeaiavclh iqtqqtvnds lcdmvhrppa
      721 msqacntepc pprwhvgswg pcsatcgvgi qtrdvyclhp getpappeec rdekphalqa
      781 cnqfdcppgw hieewqqcsr tcgggtqnrr vtcrqlltdg sflnlsdelc qgpkasshks
      841 cartdcpphl avgdwskcsv scgvgiqrrk qvcqrlaakg rriplsemmc rdlpglplvr
      901 scqmpecski ksemktklge qgpqilsvqr vyiqtreekr inltigsray llpntsviik
      961 cpvrrfqksl iqwekdgrcl qnskrlgitk sgslkihgla apdigvyrci agsaqetvvl
     1021 kligtdnrli arpalrepmr eypgmdhsea nslgvtwhkm rqmwnnkndl yldddhisnq
     1081 pflrallghc snsagstnsw elknkqfeaa vkqgaysmdt aqfdelirnm sqlmetgevs
     1141 ddlasqliyq lvaelakaqp thmqwrgiqe etppaaqlrg etgsvsqssh aknsgkltfk
     1201 pkgpvlmrqs qppsisfnkt insrigntvy itkrtevini lcdlitpsea tytwtkdgtl
     1261 lqpsvkiild gtgkiqiqnp trkeqgiyec svanhlgsdv esssvlyaea pvilsverni
     1321 tkpehnhlsv vvggiveaal ganvtircpv kgvpqpnitw lkrggslsgn vsllfngsll
     1381 lqnvsleneg tyvciatnal gkavatsvlh llerrwpesr ivflqghkky ilqatntrtn
     1441 sndptgeppp qepfwepgnw shcsatcghl gariqrpqcv mangqevsea lcdhlqkpla
     1501 gfepcnirdc parwftsvws qcsvscgegy hsrqvtckrt kangtvqvvs pracapkdrp
     1561 lgrkpcfghp cvqwepgnrc pgrcmgravr mqqrhtacqh nssdsncddr krptlrrnct
     1621 sgacdvcwht gpwkpctaac grgfqsrkvd cihtrsckpv akrhcvqkkk piswrhclgp
     1681 scdstytsqe taqtqlttvc l
//
LOCUS       XP_011520126            1697 aa            linear   PRI 05-AUG-2025
DEFINITION  ADAMTS-like protein 3 isoform X4 [Homo sapiens].
ACCESSION   XP_011520126
VERSION     XP_011520126.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521824.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1697
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1697
                     /product="ADAMTS-like protein 3 isoform X4"
                     /calculated_mol_wt=188714
     Region          78..124
                     /region_name="TSP1"
                     /note="Thrombospondin type 1 repeats; smart00209"
                     /db_xref="CDD:214559"
     Region          129..227
                     /region_name="ADAMTS_CR_3"
                     /note="ADAMTS cysteine-rich domain; pfam19236"
                     /db_xref="CDD:437068"
     Region          370..428
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          449..506
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          509..561
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          597..652
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          675..730
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          734..786
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          790..846
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          852..907
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          <956..1020
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          957..961
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          970..974
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          992..996
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          1006..1011
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          1015..1018
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          1238..1303
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cd00096"
                     /db_xref="CDD:409353"
     Region          1238..1242
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          1251..1255
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          1273..1277
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          1287..1292
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          1320..1410
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          1344..1348
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          1357..1361
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          1377..1381
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          1391..1396
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          1404..1407
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          1455..1510
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          1514..1571
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          1628..1682
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     CDS             1..1697
                     /gene="ADAMTSL3"
                     /gene_synonym="ADAMTSL-3"
                     /coded_by="XM_011521824.3:188..5281"
                     /db_xref="GeneID:57188"
                     /db_xref="HGNC:HGNC:14633"
                     /db_xref="MIM:609199"
ORIGIN      
        1 maswtspwwv ligmvfmhsp lpqttaeksp gayflpefal spqgsfledt tgeqfltyry
       61 ddqtsrntrs dedkdgnwda wgdwsdcsrt cgggasyslr rcltgrnceg qniryktcsn
      121 hdcppdaedf raqqcsaynd vqyqghyyew lpryndpaap calkchaqgq nlvvelapkv
      181 ldgtrcntds ldmcisgicq avgcdrqlgs nakedncgvc agdgstcrlv rgqskshvsp
      241 ektpglppgq ggplpgghls aiyewpilkg eenviavplg srsvritvkg pahlfieskt
      301 lqgskgehsf nspgvflven ttvefqrgse rqtfkipgpl madfifktry taakdsvvqf
      361 ffyqpishqw rqtdffpctv tcgggyqlns aecvdirlkr vvpdhychyy penvkpkpkl
      421 kecsmdpcps sdgfkeimpy dhfqplprwe hnpwtacsvs cgggiqrrsf vcveesmhge
      481 ilqveewkcm yapkpkvmqt cnlfdcpkwi amewsqctvt cgrglryrvv lcinhrgehv
      541 ggcnpqlklh ikeecvipip cykpkekspv eaklpwlkqa qeleetriat eeptfipepw
      601 sacsttcgpg vqvrevkcrv lltftqtete lpeeecegpk lpterpclle acdespasre
      661 ldiplpedse ttydweyagf tpctatcvgg hqeaiavclh iqtqqtvnds lcdmvhrppa
      721 msqacntepc pprwhvgswg pcsatcgvgi qtrdvyclhp getpappeec rdekphalqa
      781 cnqfdcppgw hieewqqcsr tcgggtqnrr vtcrqlltdg sflnlsdelc qgpkasshks
      841 cartdcpphl avgdwskcsv scgvgiqrrk qvcqrlaakg rriplsemmc rdlpglplvr
      901 scqmpecski ksemktklge qgpqilsvqr vyiqtreekr inltigsray llpntsviik
      961 cpvrrfqksl iqwekdgrcl qnskrlgitk sgslkihgla apdigvyrci agsaqetvvl
     1021 kligtdnrli arpalrepmr eypgmdhsea nslgvtwhkm rqmwnnkndl yldddhisnq
     1081 pflrallghc snsagstnsw elknkqfeaa vkqgaysmdt aqfdelirnm sqlmetgevs
     1141 ddlasqliyq lvaelakaqp thmqwrgiqe etppaaqlrg etgsvsqssh aknsgkltfk
     1201 pkgpvlmrqs qppsisfnkt insrigntvy itkrtevini lcdlitpsea tytwtkdgtl
     1261 lqpsvkiild gtgkiqiqnp trkeqgiyec svanhlgsdv esssvlyaea pvilsverni
     1321 tkpehnhlsv vvggiveaal ganvtircpv kgvpqpnitw lkrggslsgn vsllfngsll
     1381 lqnvsleneg tyvciatnal gkavatsvlh llerrwpesr ivflqghkky ilqatntrtn
     1441 sndptgeppp qepfwepgnw shcsatcghl gariqrpqcv mangqevsea lcdhlqkpla
     1501 gfepcnirdc parwftsvws qcsvscgegy hsrqvtckrt kangtvqvvs pracapkdrp
     1561 lgrkpcfghp cvqwepgnrc pgrcmgravr mqqrhtacqh nssdsncddr krptlrrnct
     1621 sgacdvcwht gpwkpctaac grgfqsrkvd cihtrsckpv akrhcvqkkk piswrhclgp
     1681 scdnrykqrc cqscqeg
//
LOCUS       XP_047288841            1682 aa            linear   PRI 05-AUG-2025
DEFINITION  ADAMTS-like protein 3 isoform X5 [Homo sapiens].
ACCESSION   XP_047288841
VERSION     XP_047288841.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432885.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1682
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1682
                     /product="ADAMTS-like protein 3 isoform X5"
                     /calculated_mol_wt=187110
     Region          78..124
                     /region_name="TSP1"
                     /note="Thrombospondin type 1 repeats; smart00209"
                     /db_xref="CDD:214559"
     Region          129..227
                     /region_name="ADAMTS_CR_3"
                     /note="ADAMTS cysteine-rich domain; pfam19236"
                     /db_xref="CDD:437068"
     Region          343..401
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          422..479
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          482..534
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          570..625
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          648..703
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          707..759
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          763..819
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          825..880
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          <929..993
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          930..934
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          943..947
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          965..969
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          979..984
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          988..991
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          1211..1276
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cd00096"
                     /db_xref="CDD:409353"
     Region          1211..1215
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          1224..1228
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          1246..1250
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          1260..1265
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          1293..1383
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          1317..1321
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          1330..1334
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          1350..1354
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          1364..1369
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          1377..1380
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          1428..1483
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          1487..1544
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          1601..1655
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     CDS             1..1682
                     /gene="ADAMTSL3"
                     /gene_synonym="ADAMTSL-3"
                     /coded_by="XM_047432885.1:205..5253"
                     /db_xref="GeneID:57188"
                     /db_xref="HGNC:HGNC:14633"
                     /db_xref="MIM:609199"
ORIGIN      
        1 maswtspwwv ligmvfmhsp lpqttaeksp gayflpefal spqgsfledt tgeqfltyry
       61 ddqtsrntrs dedkdgnwda wgdwsdcsrt cgggasyslr rcltgrnceg qniryktcsn
      121 hdcppdaedf raqqcsaynd vqyqghyyew lpryndpaap calkchaqgq nlvvelapkv
      181 ldgtrcntds ldmcisgicq avgcdrqlgs nakedncgvc agdgstcrlv rgqskshvsp
      241 ekreenviav plgsrsvrit vkgpahlfie sktlqgskge hsfnspgvfl venttvefqr
      301 gserqtfkip gplmadfifk trytaakdsv vqfffyqpis hqwrqtdffp ctvtcgggyq
      361 lnsaecvdir lkrvvpdhyc hyypenvkpk pklkecsmdp cpssdgfkei mpydhfqplp
      421 rwehnpwtac svscgggiqr rsfvcveesm hgeilqveew kcmyapkpkv mqtcnlfdcp
      481 kwiamewsqc tvtcgrglry rvvlcinhrg ehvggcnpql klhikeecvi pipcykpkek
      541 spveaklpwl kqaqeleetr iateeptfip epwsacsttc gpgvqvrevk crvlltftqt
      601 etelpeeece gpklpterpc lleacdespa sreldiplpe dsettydwey agftpctatc
      661 vgghqeaiav clhiqtqqtv ndslcdmvhr ppamsqacnt epcpprwhvg swgpcsatcg
      721 vgiqtrdvyc lhpgetpapp eecrdekpha lqacnqfdcp pgwhieewqq csrtcgggtq
      781 nrrvtcrqll tdgsflnlsd elcqgpkass hkscartdcp phlavgdwsk csvscgvgiq
      841 rrkqvcqrla akgrriplse mmcrdlpglp lvrscqmpec skiksemktk lgeqgpqils
      901 vqrvyiqtre ekrinltigs rayllpntsv iikcpvrrfq ksliqwekdg rclqnskrlg
      961 itksgslkih glaapdigvy rciagsaqet vvlkligtdn rliarpalre pmreypgmdh
     1021 seanslgvtw hkmrqmwnnk ndlyldddhi snqpflrall ghcsnsagst nswelknkqf
     1081 eaavkqgays mdtaqfdeli rnmsqlmetg evsddlasql iyqlvaelak aqpthmqwrg
     1141 iqeetppaaq lrgetgsvsq sshaknsgkl tfkpkgpvlm rqsqppsisf nktinsrign
     1201 tvyitkrtev inilcdlitp seatytwtkd gtllqpsvki ildgtgkiqi qnptrkeqgi
     1261 yecsvanhlg sdvesssvly aeapvilsve rnitkpehnh lsvvvggive aalganvtir
     1321 cpvkgvpqpn itwlkrggsl sgnvsllfng slllqnvsle negtyvciat nalgkavats
     1381 vlhllerrwp esrivflqgh kkyilqatnt rtnsndptge pppqepfwep gnwshcsatc
     1441 ghlgariqrp qcvmangqev sealcdhlqk plagfepcni rdcparwfts vwsqcsvscg
     1501 egyhsrqvtc krtkangtvq vvspracapk drplgrkpcf ghpcvqwepg nrcpgrcmgr
     1561 avrmqqrhta cqhnssdsnc ddrkrptlrr nctsgacdvc whtgpwkpct aacgrgfqsr
     1621 kvdcihtrsc kpvakrhcvq kkkpiswrhc lgpscdstyt sqtatnkgaa shvkrdkple
     1681 gs
//
LOCUS       XP_047288842            1674 aa            linear   PRI 05-AUG-2025
DEFINITION  ADAMTS-like protein 3 isoform X6 [Homo sapiens].
ACCESSION   XP_047288842
VERSION     XP_047288842.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432886.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1674
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1674
                     /product="ADAMTS-like protein 3 isoform X6"
                     /calculated_mol_wt=186350
     Region          78..124
                     /region_name="TSP1"
                     /note="Thrombospondin type 1 repeats; smart00209"
                     /db_xref="CDD:214559"
     Region          129..227
                     /region_name="ADAMTS_CR_3"
                     /note="ADAMTS cysteine-rich domain; pfam19236"
                     /db_xref="CDD:437068"
     Region          343..401
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          422..479
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          482..534
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          570..625
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          648..703
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          707..759
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          763..819
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          825..880
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          <929..993
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          930..934
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          943..947
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          965..969
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          979..984
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          988..991
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          1211..1276
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cd00096"
                     /db_xref="CDD:409353"
     Region          1211..1215
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          1224..1228
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          1246..1250
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          1260..1265
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          1293..1383
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          1317..1321
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          1330..1334
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          1350..1354
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          1364..1369
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          1377..1380
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          1428..1483
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          1487..1544
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          1601..1655
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     CDS             1..1674
                     /gene="ADAMTSL3"
                     /gene_synonym="ADAMTSL-3"
                     /coded_by="XM_047432886.1:188..5212"
                     /db_xref="GeneID:57188"
                     /db_xref="HGNC:HGNC:14633"
                     /db_xref="MIM:609199"
ORIGIN      
        1 maswtspwwv ligmvfmhsp lpqttaeksp gayflpefal spqgsfledt tgeqfltyry
       61 ddqtsrntrs dedkdgnwda wgdwsdcsrt cgggasyslr rcltgrnceg qniryktcsn
      121 hdcppdaedf raqqcsaynd vqyqghyyew lpryndpaap calkchaqgq nlvvelapkv
      181 ldgtrcntds ldmcisgicq avgcdrqlgs nakedncgvc agdgstcrlv rgqskshvsp
      241 ekreenviav plgsrsvrit vkgpahlfie sktlqgskge hsfnspgvfl venttvefqr
      301 gserqtfkip gplmadfifk trytaakdsv vqfffyqpis hqwrqtdffp ctvtcgggyq
      361 lnsaecvdir lkrvvpdhyc hyypenvkpk pklkecsmdp cpssdgfkei mpydhfqplp
      421 rwehnpwtac svscgggiqr rsfvcveesm hgeilqveew kcmyapkpkv mqtcnlfdcp
      481 kwiamewsqc tvtcgrglry rvvlcinhrg ehvggcnpql klhikeecvi pipcykpkek
      541 spveaklpwl kqaqeleetr iateeptfip epwsacsttc gpgvqvrevk crvlltftqt
      601 etelpeeece gpklpterpc lleacdespa sreldiplpe dsettydwey agftpctatc
      661 vgghqeaiav clhiqtqqtv ndslcdmvhr ppamsqacnt epcpprwhvg swgpcsatcg
      721 vgiqtrdvyc lhpgetpapp eecrdekpha lqacnqfdcp pgwhieewqq csrtcgggtq
      781 nrrvtcrqll tdgsflnlsd elcqgpkass hkscartdcp phlavgdwsk csvscgvgiq
      841 rrkqvcqrla akgrriplse mmcrdlpglp lvrscqmpec skiksemktk lgeqgpqils
      901 vqrvyiqtre ekrinltigs rayllpntsv iikcpvrrfq ksliqwekdg rclqnskrlg
      961 itksgslkih glaapdigvy rciagsaqet vvlkligtdn rliarpalre pmreypgmdh
     1021 seanslgvtw hkmrqmwnnk ndlyldddhi snqpflrall ghcsnsagst nswelknkqf
     1081 eaavkqgays mdtaqfdeli rnmsqlmetg evsddlasql iyqlvaelak aqpthmqwrg
     1141 iqeetppaaq lrgetgsvsq sshaknsgkl tfkpkgpvlm rqsqppsisf nktinsrign
     1201 tvyitkrtev inilcdlitp seatytwtkd gtllqpsvki ildgtgkiqi qnptrkeqgi
     1261 yecsvanhlg sdvesssvly aeapvilsve rnitkpehnh lsvvvggive aalganvtir
     1321 cpvkgvpqpn itwlkrggsl sgnvsllfng slllqnvsle negtyvciat nalgkavats
     1381 vlhllerrwp esrivflqgh kkyilqatnt rtnsndptge pppqepfwep gnwshcsatc
     1441 ghlgariqrp qcvmangqev sealcdhlqk plagfepcni rdcparwfts vwsqcsvscg
     1501 egyhsrqvtc krtkangtvq vvspracapk drplgrkpcf ghpcvqwepg nrcpgrcmgr
     1561 avrmqqrhta cqhnssdsnc ddrkrptlrr nctsgacdvc whtgpwkpct aacgrgfqsr
     1621 kvdcihtrsc kpvakrhcvq kkkpiswrhc lgpscdstyt sqetaqtqlt tvcl
//
LOCUS       XP_047288843            1670 aa            linear   PRI 05-AUG-2025
DEFINITION  ADAMTS-like protein 3 isoform X7 [Homo sapiens].
ACCESSION   XP_047288843
VERSION     XP_047288843.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432887.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1670
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1670
                     /product="ADAMTS-like protein 3 isoform X7"
                     /calculated_mol_wt=186078
     Region          78..124
                     /region_name="TSP1"
                     /note="Thrombospondin type 1 repeats; smart00209"
                     /db_xref="CDD:214559"
     Region          129..227
                     /region_name="ADAMTS_CR_3"
                     /note="ADAMTS cysteine-rich domain; pfam19236"
                     /db_xref="CDD:437068"
     Region          343..401
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          422..479
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          482..534
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          570..625
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          648..703
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          707..759
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          763..819
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          825..880
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          <929..993
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          930..934
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          943..947
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          965..969
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          979..984
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          988..991
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          1211..1276
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cd00096"
                     /db_xref="CDD:409353"
     Region          1211..1215
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          1224..1228
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          1246..1250
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          1260..1265
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          1293..1383
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          1317..1321
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          1330..1334
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          1350..1354
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          1364..1369
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          1377..1380
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          1428..1483
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          1487..1544
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          1601..1655
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     CDS             1..1670
                     /gene="ADAMTSL3"
                     /gene_synonym="ADAMTSL-3"
                     /coded_by="XM_047432887.1:188..5200"
                     /db_xref="GeneID:57188"
                     /db_xref="HGNC:HGNC:14633"
                     /db_xref="MIM:609199"
ORIGIN      
        1 maswtspwwv ligmvfmhsp lpqttaeksp gayflpefal spqgsfledt tgeqfltyry
       61 ddqtsrntrs dedkdgnwda wgdwsdcsrt cgggasyslr rcltgrnceg qniryktcsn
      121 hdcppdaedf raqqcsaynd vqyqghyyew lpryndpaap calkchaqgq nlvvelapkv
      181 ldgtrcntds ldmcisgicq avgcdrqlgs nakedncgvc agdgstcrlv rgqskshvsp
      241 ekreenviav plgsrsvrit vkgpahlfie sktlqgskge hsfnspgvfl venttvefqr
      301 gserqtfkip gplmadfifk trytaakdsv vqfffyqpis hqwrqtdffp ctvtcgggyq
      361 lnsaecvdir lkrvvpdhyc hyypenvkpk pklkecsmdp cpssdgfkei mpydhfqplp
      421 rwehnpwtac svscgggiqr rsfvcveesm hgeilqveew kcmyapkpkv mqtcnlfdcp
      481 kwiamewsqc tvtcgrglry rvvlcinhrg ehvggcnpql klhikeecvi pipcykpkek
      541 spveaklpwl kqaqeleetr iateeptfip epwsacsttc gpgvqvrevk crvlltftqt
      601 etelpeeece gpklpterpc lleacdespa sreldiplpe dsettydwey agftpctatc
      661 vgghqeaiav clhiqtqqtv ndslcdmvhr ppamsqacnt epcpprwhvg swgpcsatcg
      721 vgiqtrdvyc lhpgetpapp eecrdekpha lqacnqfdcp pgwhieewqq csrtcgggtq
      781 nrrvtcrqll tdgsflnlsd elcqgpkass hkscartdcp phlavgdwsk csvscgvgiq
      841 rrkqvcqrla akgrriplse mmcrdlpglp lvrscqmpec skiksemktk lgeqgpqils
      901 vqrvyiqtre ekrinltigs rayllpntsv iikcpvrrfq ksliqwekdg rclqnskrlg
      961 itksgslkih glaapdigvy rciagsaqet vvlkligtdn rliarpalre pmreypgmdh
     1021 seanslgvtw hkmrqmwnnk ndlyldddhi snqpflrall ghcsnsagst nswelknkqf
     1081 eaavkqgays mdtaqfdeli rnmsqlmetg evsddlasql iyqlvaelak aqpthmqwrg
     1141 iqeetppaaq lrgetgsvsq sshaknsgkl tfkpkgpvlm rqsqppsisf nktinsrign
     1201 tvyitkrtev inilcdlitp seatytwtkd gtllqpsvki ildgtgkiqi qnptrkeqgi
     1261 yecsvanhlg sdvesssvly aeapvilsve rnitkpehnh lsvvvggive aalganvtir
     1321 cpvkgvpqpn itwlkrggsl sgnvsllfng slllqnvsle negtyvciat nalgkavats
     1381 vlhllerrwp esrivflqgh kkyilqatnt rtnsndptge pppqepfwep gnwshcsatc
     1441 ghlgariqrp qcvmangqev sealcdhlqk plagfepcni rdcparwfts vwsqcsvscg
     1501 egyhsrqvtc krtkangtvq vvspracapk drplgrkpcf ghpcvqwepg nrcpgrcmgr
     1561 avrmqqrhta cqhnssdsnc ddrkrptlrr nctsgacdvc whtgpwkpct aacgrgfqsr
     1621 kvdcihtrsc kpvakrhcvq kkkpiswrhc lgpscdnryk qrccqscqeg
//
LOCUS       XP_011520127            1413 aa            linear   PRI 05-AUG-2025
DEFINITION  ADAMTS-like protein 3 isoform X8 [Homo sapiens].
ACCESSION   XP_011520127
VERSION     XP_011520127.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521825.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1413
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1413
                     /product="ADAMTS-like protein 3 isoform X8"
                     /calculated_mol_wt=156628
     Region          78..124
                     /region_name="TSP1"
                     /note="Thrombospondin type 1 repeats; smart00209"
                     /db_xref="CDD:214559"
     Region          129..227
                     /region_name="ADAMTS_CR_3"
                     /note="ADAMTS cysteine-rich domain; pfam19236"
                     /db_xref="CDD:437068"
     Region          370..428
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          449..506
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          509..561
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          597..652
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          675..730
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          734..786
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          790..846
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          852..907
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          <956..1020
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          957..961
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          970..974
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          992..996
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          1006..1011
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          1015..1018
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          1238..1303
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cd00096"
                     /db_xref="CDD:409353"
     Region          1238..1242
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          1251..1255
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          1273..1277
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          1287..1292
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          1320..1410
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          1344..1348
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          1357..1361
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          1377..1381
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          1391..1396
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          1404..1407
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     CDS             1..1413
                     /gene="ADAMTSL3"
                     /gene_synonym="ADAMTSL-3"
                     /coded_by="XM_011521825.3:188..4429"
                     /db_xref="GeneID:57188"
                     /db_xref="HGNC:HGNC:14633"
                     /db_xref="MIM:609199"
ORIGIN      
        1 maswtspwwv ligmvfmhsp lpqttaeksp gayflpefal spqgsfledt tgeqfltyry
       61 ddqtsrntrs dedkdgnwda wgdwsdcsrt cgggasyslr rcltgrnceg qniryktcsn
      121 hdcppdaedf raqqcsaynd vqyqghyyew lpryndpaap calkchaqgq nlvvelapkv
      181 ldgtrcntds ldmcisgicq avgcdrqlgs nakedncgvc agdgstcrlv rgqskshvsp
      241 ektpglppgq ggplpgghls aiyewpilkg eenviavplg srsvritvkg pahlfieskt
      301 lqgskgehsf nspgvflven ttvefqrgse rqtfkipgpl madfifktry taakdsvvqf
      361 ffyqpishqw rqtdffpctv tcgggyqlns aecvdirlkr vvpdhychyy penvkpkpkl
      421 kecsmdpcps sdgfkeimpy dhfqplprwe hnpwtacsvs cgggiqrrsf vcveesmhge
      481 ilqveewkcm yapkpkvmqt cnlfdcpkwi amewsqctvt cgrglryrvv lcinhrgehv
      541 ggcnpqlklh ikeecvipip cykpkekspv eaklpwlkqa qeleetriat eeptfipepw
      601 sacsttcgpg vqvrevkcrv lltftqtete lpeeecegpk lpterpclle acdespasre
      661 ldiplpedse ttydweyagf tpctatcvgg hqeaiavclh iqtqqtvnds lcdmvhrppa
      721 msqacntepc pprwhvgswg pcsatcgvgi qtrdvyclhp getpappeec rdekphalqa
      781 cnqfdcppgw hieewqqcsr tcgggtqnrr vtcrqlltdg sflnlsdelc qgpkasshks
      841 cartdcpphl avgdwskcsv scgvgiqrrk qvcqrlaakg rriplsemmc rdlpglplvr
      901 scqmpecski ksemktklge qgpqilsvqr vyiqtreekr inltigsray llpntsviik
      961 cpvrrfqksl iqwekdgrcl qnskrlgitk sgslkihgla apdigvyrci agsaqetvvl
     1021 kligtdnrli arpalrepmr eypgmdhsea nslgvtwhkm rqmwnnkndl yldddhisnq
     1081 pflrallghc snsagstnsw elknkqfeaa vkqgaysmdt aqfdelirnm sqlmetgevs
     1141 ddlasqliyq lvaelakaqp thmqwrgiqe etppaaqlrg etgsvsqssh aknsgkltfk
     1201 pkgpvlmrqs qppsisfnkt insrigntvy itkrtevini lcdlitpsea tytwtkdgtl
     1261 lqpsvkiild gtgkiqiqnp trkeqgiyec svanhlgsdv esssvlyaea pvilsverni
     1321 tkpehnhlsv vvggiveaal ganvtircpv kgvpqpnitw lkrggslsgn vsllfngsll
     1381 lqnvsleneg tyvciatnal gkavatsvlh llg
//
LOCUS       XP_047288844             872 aa            linear   PRI 05-AUG-2025
DEFINITION  ADAMTS-like protein 3 isoform X9 [Homo sapiens].
ACCESSION   XP_047288844
VERSION     XP_047288844.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432888.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..872
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..872
                     /product="ADAMTS-like protein 3 isoform X9"
                     /calculated_mol_wt=97090
     Region          78..124
                     /region_name="TSP1"
                     /note="Thrombospondin type 1 repeats; smart00209"
                     /db_xref="CDD:214559"
     Region          129..227
                     /region_name="ADAMTS_CR_3"
                     /note="ADAMTS cysteine-rich domain; pfam19236"
                     /db_xref="CDD:437068"
     Region          370..428
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          449..506
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          509..561
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          597..652
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          675..730
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          734..786
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          790..846
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     CDS             1..872
                     /gene="ADAMTSL3"
                     /gene_synonym="ADAMTSL-3"
                     /coded_by="XM_047432888.1:188..2806"
                     /db_xref="GeneID:57188"
                     /db_xref="HGNC:HGNC:14633"
                     /db_xref="MIM:609199"
ORIGIN      
        1 maswtspwwv ligmvfmhsp lpqttaeksp gayflpefal spqgsfledt tgeqfltyry
       61 ddqtsrntrs dedkdgnwda wgdwsdcsrt cgggasyslr rcltgrnceg qniryktcsn
      121 hdcppdaedf raqqcsaynd vqyqghyyew lpryndpaap calkchaqgq nlvvelapkv
      181 ldgtrcntds ldmcisgicq avgcdrqlgs nakedncgvc agdgstcrlv rgqskshvsp
      241 ektpglppgq ggplpgghls aiyewpilkg eenviavplg srsvritvkg pahlfieskt
      301 lqgskgehsf nspgvflven ttvefqrgse rqtfkipgpl madfifktry taakdsvvqf
      361 ffyqpishqw rqtdffpctv tcgggyqlns aecvdirlkr vvpdhychyy penvkpkpkl
      421 kecsmdpcps sdgfkeimpy dhfqplprwe hnpwtacsvs cgggiqrrsf vcveesmhge
      481 ilqveewkcm yapkpkvmqt cnlfdcpkwi amewsqctvt cgrglryrvv lcinhrgehv
      541 ggcnpqlklh ikeecvipip cykpkekspv eaklpwlkqa qeleetriat eeptfipepw
      601 sacsttcgpg vqvrevkcrv lltftqtete lpeeecegpk lpterpclle acdespasre
      661 ldiplpedse ttydweyagf tpctatcvgg hqeaiavclh iqtqqtvnds lcdmvhrppa
      721 msqacntepc pprwhvgswg pcsatcgvgi qtrdvyclhp getpappeec rdekphalqa
      781 cnqfdcppgw hieewqqcsr tcgggtqnrr vtcrqlltdg sflnlsdelc qgpkasshks
      841 cartdcpphl avgdwskehs mqedngagst qf
//
LOCUS       XP_047288845             845 aa            linear   PRI 05-AUG-2025
DEFINITION  ADAMTS-like protein 3 isoform X10 [Homo sapiens].
ACCESSION   XP_047288845
VERSION     XP_047288845.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432889.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..845
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..845
                     /product="ADAMTS-like protein 3 isoform X10"
                     /calculated_mol_wt=94454
     Region          78..124
                     /region_name="TSP1"
                     /note="Thrombospondin type 1 repeats; smart00209"
                     /db_xref="CDD:214559"
     Region          129..227
                     /region_name="ADAMTS_CR_3"
                     /note="ADAMTS cysteine-rich domain; pfam19236"
                     /db_xref="CDD:437068"
     Region          343..401
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          422..479
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          482..534
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          570..625
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          648..703
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          707..759
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          763..819
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     CDS             1..845
                     /gene="ADAMTSL3"
                     /gene_synonym="ADAMTSL-3"
                     /coded_by="XM_047432889.1:188..2725"
                     /db_xref="GeneID:57188"
                     /db_xref="HGNC:HGNC:14633"
                     /db_xref="MIM:609199"
ORIGIN      
        1 maswtspwwv ligmvfmhsp lpqttaeksp gayflpefal spqgsfledt tgeqfltyry
       61 ddqtsrntrs dedkdgnwda wgdwsdcsrt cgggasyslr rcltgrnceg qniryktcsn
      121 hdcppdaedf raqqcsaynd vqyqghyyew lpryndpaap calkchaqgq nlvvelapkv
      181 ldgtrcntds ldmcisgicq avgcdrqlgs nakedncgvc agdgstcrlv rgqskshvsp
      241 ekreenviav plgsrsvrit vkgpahlfie sktlqgskge hsfnspgvfl venttvefqr
      301 gserqtfkip gplmadfifk trytaakdsv vqfffyqpis hqwrqtdffp ctvtcgggyq
      361 lnsaecvdir lkrvvpdhyc hyypenvkpk pklkecsmdp cpssdgfkei mpydhfqplp
      421 rwehnpwtac svscgggiqr rsfvcveesm hgeilqveew kcmyapkpkv mqtcnlfdcp
      481 kwiamewsqc tvtcgrglry rvvlcinhrg ehvggcnpql klhikeecvi pipcykpkek
      541 spveaklpwl kqaqeleetr iateeptfip epwsacsttc gpgvqvrevk crvlltftqt
      601 etelpeeece gpklpterpc lleacdespa sreldiplpe dsettydwey agftpctatc
      661 vgghqeaiav clhiqtqqtv ndslcdmvhr ppamsqacnt epcpprwhvg swgpcsatcg
      721 vgiqtrdvyc lhpgetpapp eecrdekpha lqacnqfdcp pgwhieewqq csrtcgggtq
      781 nrrvtcrqll tdgsflnlsd elcqgpkass hkscartdcp phlavgdwsk ehsmqednga
      841 gstqf
//
LOCUS       XP_011520128            1499 aa            linear   PRI 05-AUG-2025
DEFINITION  phospholipid-transporting ATPase VA isoform X1 [Homo sapiens].
ACCESSION   XP_011520128
VERSION     XP_011520128.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521826.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1499
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1499
                     /product="phospholipid-transporting ATPase VA isoform X1"
                     /calculated_mol_wt=167558
     Region          61..1189
                     /region_name="P-type_ATPase_APLT_Dnf-like"
                     /note="Aminophospholipid translocases (APLTs), similar to
                     Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2,
                     -10D, -11B, -11C; cd02073"
                     /db_xref="CDD:319770"
     Site            order(427..429,742,766..768,842,889..891,1005,1008,1011,
                     1031,1034)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:319770"
     CDS             1..1499
                     /gene="ATP10A"
                     /gene_synonym="ATP10C; ATPVA; ATPVC"
                     /coded_by="XM_011521826.3:450..4949"
                     /db_xref="GeneID:57194"
                     /db_xref="HGNC:HGNC:13542"
                     /db_xref="MIM:605855"
ORIGIN      
        1 merepagtee pgppgrrrrr egrtrtvrsn llpppgaedp aagaakgerr rrrgcaqhla
       61 dnrlkttkyt llsflpknlf eqfhrpanvy fvfiallnfv pavnafqpgl alapvlfila
      121 itafrdlwed ysrhrsdhki nhlgclvfsr eekkyvnrfw keihvgdfvr lrcneifpad
      181 illlsssdpd glchietanl dgetnlkrrq vvrgfselvs efnpltftsv iecekpnndl
      241 srfrgciihd ngkkaglyke nlllrgctlr ntdavvgivi yaghetkall nnsgprykrs
      301 klerqmncdv lwcvlllvcm slfsavghgl wiwryqekks lfyvpksdgs slspvtaavy
      361 sfltmiivlq vlipislyvs ieivkacqvy finqdmqlyd eetdsqlqcr alnitedlgq
      421 iqyifsdktg tltenkmvfr rctvsgveys hdanaqrlar yqeadseeee vvprggsvsq
      481 rgsigshqsv rvvhrtqstk shrrtgsrae akrasmlskh tafsspmekd itpdpkllek
      541 vsecdkslav arhqehllah lspelsdvfd ffialticnt vvvtspdqpr tkvrvrfelk
      601 spvktiedfl rrftpsclts gcssigslaa nksshklgss fpstpssdgm llrleerlgq
      661 ptsaiasngy ssqadnwase laqeqesere lryeaespde aalvyaaray ncvlverlhd
      721 qvsvelphlg rltfellhtl gfdsvrkrms vvirhpltde invytkgads vvmdllqpcs
      781 svdargrhqk kirsktqnyl nvyaaeglrt lciakrvlsk eeyacwlqsh leaesslens
      841 eellfqsair letnlhllga tgiedrlqdg vpetisklrq aglqiwvltg dkqetavnia
      901 yacklldhde evitlnatsq eacaalldqc lcyvqsrglq rapektkgkv smrfsslcpp
      961 ststasgrrp slvidgrsla yaleknledk flflakqcrs vlccrstplq ksmvvklvrs
     1021 klkamtlaig dgandvsmiq vadvgvgisg qegmqavmas dfavpkfryl erllilhghw
     1081 cysrlanmvl yffykntmfv gllfwfqffc gfsastmidq wyliffnllf sslpplvtgv
     1141 ldrdvpanvl ltnpqlyksg qnmeeyrprt fwfnmadaaf qslvcfsipy layydsnvdl
     1201 ftwgtpivti alltfllhlg ietktwtwln witcgfsvll fftvaliyna scatcyppsn
     1261 pywtmqallg dpvfyltclm tpvaallprl ffrslqgrvf ptqlqlarql trksprrcsa
     1321 pketfaqgrl pkdsgtehss grtvktsvpl sqpswhtqqp vcsleasgep stvdmsmpvr
     1381 ehtlleglsa papmssapge avlrspggcp eeskvraast grvtplsslf slptfsllnw
     1441 isswslvsrl gsvlqfsrte qladgqagrg lpvqphsgrs glqgpdhrll igassrrsq
//
LOCUS       XP_005268318            1499 aa            linear   PRI 05-AUG-2025
DEFINITION  phospholipid-transporting ATPase VA isoform X1 [Homo sapiens].
ACCESSION   XP_005268318
VERSION     XP_005268318.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005268261.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1499
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1499
                     /product="phospholipid-transporting ATPase VA isoform X1"
                     /calculated_mol_wt=167558
     Region          61..1189
                     /region_name="P-type_ATPase_APLT_Dnf-like"
                     /note="Aminophospholipid translocases (APLTs), similar to
                     Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2,
                     -10D, -11B, -11C; cd02073"
                     /db_xref="CDD:319770"
     Site            order(427..429,742,766..768,842,889..891,1005,1008,1011,
                     1031,1034)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:319770"
     CDS             1..1499
                     /gene="ATP10A"
                     /gene_synonym="ATP10C; ATPVA; ATPVC"
                     /coded_by="XM_005268261.5:181..4680"
                     /db_xref="GeneID:57194"
                     /db_xref="HGNC:HGNC:13542"
                     /db_xref="MIM:605855"
ORIGIN      
        1 merepagtee pgppgrrrrr egrtrtvrsn llpppgaedp aagaakgerr rrrgcaqhla
       61 dnrlkttkyt llsflpknlf eqfhrpanvy fvfiallnfv pavnafqpgl alapvlfila
      121 itafrdlwed ysrhrsdhki nhlgclvfsr eekkyvnrfw keihvgdfvr lrcneifpad
      181 illlsssdpd glchietanl dgetnlkrrq vvrgfselvs efnpltftsv iecekpnndl
      241 srfrgciihd ngkkaglyke nlllrgctlr ntdavvgivi yaghetkall nnsgprykrs
      301 klerqmncdv lwcvlllvcm slfsavghgl wiwryqekks lfyvpksdgs slspvtaavy
      361 sfltmiivlq vlipislyvs ieivkacqvy finqdmqlyd eetdsqlqcr alnitedlgq
      421 iqyifsdktg tltenkmvfr rctvsgveys hdanaqrlar yqeadseeee vvprggsvsq
      481 rgsigshqsv rvvhrtqstk shrrtgsrae akrasmlskh tafsspmekd itpdpkllek
      541 vsecdkslav arhqehllah lspelsdvfd ffialticnt vvvtspdqpr tkvrvrfelk
      601 spvktiedfl rrftpsclts gcssigslaa nksshklgss fpstpssdgm llrleerlgq
      661 ptsaiasngy ssqadnwase laqeqesere lryeaespde aalvyaaray ncvlverlhd
      721 qvsvelphlg rltfellhtl gfdsvrkrms vvirhpltde invytkgads vvmdllqpcs
      781 svdargrhqk kirsktqnyl nvyaaeglrt lciakrvlsk eeyacwlqsh leaesslens
      841 eellfqsair letnlhllga tgiedrlqdg vpetisklrq aglqiwvltg dkqetavnia
      901 yacklldhde evitlnatsq eacaalldqc lcyvqsrglq rapektkgkv smrfsslcpp
      961 ststasgrrp slvidgrsla yaleknledk flflakqcrs vlccrstplq ksmvvklvrs
     1021 klkamtlaig dgandvsmiq vadvgvgisg qegmqavmas dfavpkfryl erllilhghw
     1081 cysrlanmvl yffykntmfv gllfwfqffc gfsastmidq wyliffnllf sslpplvtgv
     1141 ldrdvpanvl ltnpqlyksg qnmeeyrprt fwfnmadaaf qslvcfsipy layydsnvdl
     1201 ftwgtpivti alltfllhlg ietktwtwln witcgfsvll fftvaliyna scatcyppsn
     1261 pywtmqallg dpvfyltclm tpvaallprl ffrslqgrvf ptqlqlarql trksprrcsa
     1321 pketfaqgrl pkdsgtehss grtvktsvpl sqpswhtqqp vcsleasgep stvdmsmpvr
     1381 ehtlleglsa papmssapge avlrspggcp eeskvraast grvtplsslf slptfsllnw
     1441 isswslvsrl gsvlqfsrte qladgqagrg lpvqphsgrs glqgpdhrll igassrrsq
//
LOCUS       XP_011520130            1416 aa            linear   PRI 05-AUG-2025
DEFINITION  phospholipid-transporting ATPase VA isoform X2 [Homo sapiens].
ACCESSION   XP_011520130
VERSION     XP_011520130.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521828.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1416
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1416
                     /product="phospholipid-transporting ATPase VA isoform X2"
                     /calculated_mol_wt=158721
     Region          61..1189
                     /region_name="P-type_ATPase_APLT_Dnf-like"
                     /note="Aminophospholipid translocases (APLTs), similar to
                     Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2,
                     -10D, -11B, -11C; cd02073"
                     /db_xref="CDD:319770"
     Site            order(427..429,742,766..768,842,889..891,1005,1008,1011,
                     1031,1034)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:319770"
     CDS             1..1416
                     /gene="ATP10A"
                     /gene_synonym="ATP10C; ATPVA; ATPVC"
                     /coded_by="XM_011521828.3:232..4482"
                     /db_xref="GeneID:57194"
                     /db_xref="HGNC:HGNC:13542"
                     /db_xref="MIM:605855"
ORIGIN      
        1 merepagtee pgppgrrrrr egrtrtvrsn llpppgaedp aagaakgerr rrrgcaqhla
       61 dnrlkttkyt llsflpknlf eqfhrpanvy fvfiallnfv pavnafqpgl alapvlfila
      121 itafrdlwed ysrhrsdhki nhlgclvfsr eekkyvnrfw keihvgdfvr lrcneifpad
      181 illlsssdpd glchietanl dgetnlkrrq vvrgfselvs efnpltftsv iecekpnndl
      241 srfrgciihd ngkkaglyke nlllrgctlr ntdavvgivi yaghetkall nnsgprykrs
      301 klerqmncdv lwcvlllvcm slfsavghgl wiwryqekks lfyvpksdgs slspvtaavy
      361 sfltmiivlq vlipislyvs ieivkacqvy finqdmqlyd eetdsqlqcr alnitedlgq
      421 iqyifsdktg tltenkmvfr rctvsgveys hdanaqrlar yqeadseeee vvprggsvsq
      481 rgsigshqsv rvvhrtqstk shrrtgsrae akrasmlskh tafsspmekd itpdpkllek
      541 vsecdkslav arhqehllah lspelsdvfd ffialticnt vvvtspdqpr tkvrvrfelk
      601 spvktiedfl rrftpsclts gcssigslaa nksshklgss fpstpssdgm llrleerlgq
      661 ptsaiasngy ssqadnwase laqeqesere lryeaespde aalvyaaray ncvlverlhd
      721 qvsvelphlg rltfellhtl gfdsvrkrms vvirhpltde invytkgads vvmdllqpcs
      781 svdargrhqk kirsktqnyl nvyaaeglrt lciakrvlsk eeyacwlqsh leaesslens
      841 eellfqsair letnlhllga tgiedrlqdg vpetisklrq aglqiwvltg dkqetavnia
      901 yacklldhde evitlnatsq eacaalldqc lcyvqsrglq rapektkgkv smrfsslcpp
      961 ststasgrrp slvidgrsla yaleknledk flflakqcrs vlccrstplq ksmvvklvrs
     1021 klkamtlaig dgandvsmiq vadvgvgisg qegmqavmas dfavpkfryl erllilhghw
     1081 cysrlanmvl yffykntmfv gllfwfqffc gfsastmidq wyliffnllf sslpplvtgv
     1141 ldrdvpanvl ltnpqlyksg qnmeeyrprt fwfnmadaaf qslvcfsipy layydsnvdl
     1201 ftwgtpivti alltfllhlg ietktwtwln witcgfsvll fftvaliyna scatcyppsn
     1261 pywtmqallg dpvfyltclm tpvaallprl ffrslqgrvf ptqlqlarql trksprrcsa
     1321 pketfaqgrl pkdsgtehss grtvktsvpl sqpswhtqqp vcsleasgep stvdmsmpvr
     1381 ehtlleglsa papmssapge avlrspggcp eesklm
//
LOCUS       XP_016877926            1194 aa            linear   PRI 05-AUG-2025
DEFINITION  phospholipid-transporting ATPase VA isoform X3 [Homo sapiens].
ACCESSION   XP_016877926
VERSION     XP_016877926.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022437.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1194
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1194
                     /product="phospholipid-transporting ATPase VA isoform X3"
                     /calculated_mol_wt=132842
     Region          <1..884
                     /region_name="Haloacid Dehalogenase-like Hydrolases"
                     /note="The haloacid dehalogenase (HAD) superfamily
                     includes carbon and phosphorus hydrolases such as
                     2-haloalkonoate dehalogenase, epoxide hydrolase,
                     phosphoserine phosphatase, phosphomannomutase,
                     phosphoglycolate phosphatase, P-type ATPase, among others.
                     These...; cl21460"
                     /db_xref="CDD:473868"
     Site            order(122..126,584..585,706,725..726,729..730)
                     /site_type="active"
                     /db_xref="CDD:319770"
     CDS             1..1194
                     /gene="ATP10A"
                     /gene_synonym="ATP10C; ATPVA; ATPVC"
                     /coded_by="XM_017022437.2:995..4579"
                     /db_xref="GeneID:57194"
                     /db_xref="HGNC:HGNC:13542"
                     /db_xref="MIM:605855"
ORIGIN      
        1 mncdvlwcvl llvcmslfsa vghglwiwry qekkslfyvp ksdgsslspv taavysfltm
       61 iivlqvlipi slyvsieivk acqvyfinqd mqlydeetds qlqcralnit edlgqiqyif
      121 sdktgtlten kmvfrrctvs gveyshdana qrlaryqead seeeevvprg gsvsqrgsig
      181 shqsvrvvhr tqstkshrrt gsraeakras mlskhtafss pmekditpdp kllekvsecd
      241 kslavarhqe hllahlspel sdvfdffial ticntvvvts pdqprtkvrv rfelkspvkt
      301 iedflrrftp scltsgcssi gslaankssh klgssfpstp ssdgmllrle erlgqptsai
      361 asngyssqad nwaselaqeq eserelryea espdeaalvy aarayncvlv erlhdqvsve
      421 lphlgrltfe llhtlgfdsv rkrmsvvirh pltdeinvyt kgadsvvmdl lqpcssvdar
      481 grhqkkirsk tqnylnvyaa eglrtlciak rvlskeeyac wlqshleaes slenseellf
      541 qsairletnl hllgatgied rlqdgvpeti sklrqaglqi wvltgdkqet avniayackl
      601 ldhdeevitl natsqeacaa lldqclcyvq srglqrapek tkgkvsmrfs slcppststa
      661 sgrrpslvid grslayalek nledkflfla kqcrsvlccr stplqksmvv klvrsklkam
      721 tlaigdgand vsmiqvadvg vgisgqegmq avmasdfavp kfrylerlli lhghwcysrl
      781 anmvlyffyk ntmfvgllfw fqffcgfsas tmidqwylif fnllfsslpp lvtgvldrdv
      841 panvlltnpq lyksgqnmee yrprtfwfnm adaafqslvc fsipylayyd snvdlftwgt
      901 pivtialltf llhlgietkt wtwlnwitcg fsvllfftva liynascatc yppsnpywtm
      961 qallgdpvfy ltclmtpvaa llprlffrsl qgrvfptqlq larqltrksp rrcsapketf
     1021 aqgrlpkdsg tehssgrtvk tsvplsqpsw htqqpvcsle asgepstvdm smpvrehtll
     1081 eglsapapms sapgeavlrs pggcpeeskv raastgrvtp lsslfslptf sllnwissws
     1141 lvsrlgsvlq fsrteqladg qagrglpvqp hsgrsglqgp dhrlligass rrsq
//
LOCUS       XP_047288846            1194 aa            linear   PRI 05-AUG-2025
DEFINITION  phospholipid-transporting ATPase VA isoform X3 [Homo sapiens].
ACCESSION   XP_047288846
VERSION     XP_047288846.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432890.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1194
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1194
                     /product="phospholipid-transporting ATPase VA isoform X3"
                     /calculated_mol_wt=132842
     Region          <1..884
                     /region_name="Haloacid Dehalogenase-like Hydrolases"
                     /note="The haloacid dehalogenase (HAD) superfamily
                     includes carbon and phosphorus hydrolases such as
                     2-haloalkonoate dehalogenase, epoxide hydrolase,
                     phosphoserine phosphatase, phosphomannomutase,
                     phosphoglycolate phosphatase, P-type ATPase, among others.
                     These...; cl21460"
                     /db_xref="CDD:473868"
     Site            order(122..126,584..585,706,725..726,729..730)
                     /site_type="active"
                     /db_xref="CDD:319770"
     CDS             1..1194
                     /gene="ATP10A"
                     /gene_synonym="ATP10C; ATPVA; ATPVC"
                     /coded_by="XM_047432890.1:776..4360"
                     /db_xref="GeneID:57194"
                     /db_xref="HGNC:HGNC:13542"
                     /db_xref="MIM:605855"
ORIGIN      
        1 mncdvlwcvl llvcmslfsa vghglwiwry qekkslfyvp ksdgsslspv taavysfltm
       61 iivlqvlipi slyvsieivk acqvyfinqd mqlydeetds qlqcralnit edlgqiqyif
      121 sdktgtlten kmvfrrctvs gveyshdana qrlaryqead seeeevvprg gsvsqrgsig
      181 shqsvrvvhr tqstkshrrt gsraeakras mlskhtafss pmekditpdp kllekvsecd
      241 kslavarhqe hllahlspel sdvfdffial ticntvvvts pdqprtkvrv rfelkspvkt
      301 iedflrrftp scltsgcssi gslaankssh klgssfpstp ssdgmllrle erlgqptsai
      361 asngyssqad nwaselaqeq eserelryea espdeaalvy aarayncvlv erlhdqvsve
      421 lphlgrltfe llhtlgfdsv rkrmsvvirh pltdeinvyt kgadsvvmdl lqpcssvdar
      481 grhqkkirsk tqnylnvyaa eglrtlciak rvlskeeyac wlqshleaes slenseellf
      541 qsairletnl hllgatgied rlqdgvpeti sklrqaglqi wvltgdkqet avniayackl
      601 ldhdeevitl natsqeacaa lldqclcyvq srglqrapek tkgkvsmrfs slcppststa
      661 sgrrpslvid grslayalek nledkflfla kqcrsvlccr stplqksmvv klvrsklkam
      721 tlaigdgand vsmiqvadvg vgisgqegmq avmasdfavp kfrylerlli lhghwcysrl
      781 anmvlyffyk ntmfvgllfw fqffcgfsas tmidqwylif fnllfsslpp lvtgvldrdv
      841 panvlltnpq lyksgqnmee yrprtfwfnm adaafqslvc fsipylayyd snvdlftwgt
      901 pivtialltf llhlgietkt wtwlnwitcg fsvllfftva liynascatc yppsnpywtm
      961 qallgdpvfy ltclmtpvaa llprlffrsl qgrvfptqlq larqltrksp rrcsapketf
     1021 aqgrlpkdsg tehssgrtvk tsvplsqpsw htqqpvcsle asgepstvdm smpvrehtll
     1081 eglsapapms sapgeavlrs pggcpeeskv raastgrvtp lsslfslptf sllnwissws
     1141 lvsrlgsvlq fsrteqladg qagrglpvqp hsgrsglqgp dhrlligass rrsq
//
LOCUS       XP_047288847            1194 aa            linear   PRI 05-AUG-2025
DEFINITION  phospholipid-transporting ATPase VA isoform X3 [Homo sapiens].
ACCESSION   XP_047288847
VERSION     XP_047288847.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432891.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1194
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1194
                     /product="phospholipid-transporting ATPase VA isoform X3"
                     /calculated_mol_wt=132842
     Region          <1..884
                     /region_name="Haloacid Dehalogenase-like Hydrolases"
                     /note="The haloacid dehalogenase (HAD) superfamily
                     includes carbon and phosphorus hydrolases such as
                     2-haloalkonoate dehalogenase, epoxide hydrolase,
                     phosphoserine phosphatase, phosphomannomutase,
                     phosphoglycolate phosphatase, P-type ATPase, among others.
                     These...; cl21460"
                     /db_xref="CDD:473868"
     Site            order(122..126,584..585,706,725..726,729..730)
                     /site_type="active"
                     /db_xref="CDD:319770"
     CDS             1..1194
                     /gene="ATP10A"
                     /gene_synonym="ATP10C; ATPVA; ATPVC"
                     /coded_by="XM_047432891.1:714..4298"
                     /db_xref="GeneID:57194"
                     /db_xref="HGNC:HGNC:13542"
                     /db_xref="MIM:605855"
ORIGIN      
        1 mncdvlwcvl llvcmslfsa vghglwiwry qekkslfyvp ksdgsslspv taavysfltm
       61 iivlqvlipi slyvsieivk acqvyfinqd mqlydeetds qlqcralnit edlgqiqyif
      121 sdktgtlten kmvfrrctvs gveyshdana qrlaryqead seeeevvprg gsvsqrgsig
      181 shqsvrvvhr tqstkshrrt gsraeakras mlskhtafss pmekditpdp kllekvsecd
      241 kslavarhqe hllahlspel sdvfdffial ticntvvvts pdqprtkvrv rfelkspvkt
      301 iedflrrftp scltsgcssi gslaankssh klgssfpstp ssdgmllrle erlgqptsai
      361 asngyssqad nwaselaqeq eserelryea espdeaalvy aarayncvlv erlhdqvsve
      421 lphlgrltfe llhtlgfdsv rkrmsvvirh pltdeinvyt kgadsvvmdl lqpcssvdar
      481 grhqkkirsk tqnylnvyaa eglrtlciak rvlskeeyac wlqshleaes slenseellf
      541 qsairletnl hllgatgied rlqdgvpeti sklrqaglqi wvltgdkqet avniayackl
      601 ldhdeevitl natsqeacaa lldqclcyvq srglqrapek tkgkvsmrfs slcppststa
      661 sgrrpslvid grslayalek nledkflfla kqcrsvlccr stplqksmvv klvrsklkam
      721 tlaigdgand vsmiqvadvg vgisgqegmq avmasdfavp kfrylerlli lhghwcysrl
      781 anmvlyffyk ntmfvgllfw fqffcgfsas tmidqwylif fnllfsslpp lvtgvldrdv
      841 panvlltnpq lyksgqnmee yrprtfwfnm adaafqslvc fsipylayyd snvdlftwgt
      901 pivtialltf llhlgietkt wtwlnwitcg fsvllfftva liynascatc yppsnpywtm
      961 qallgdpvfy ltclmtpvaa llprlffrsl qgrvfptqlq larqltrksp rrcsapketf
     1021 aqgrlpkdsg tehssgrtvk tsvplsqpsw htqqpvcsle asgepstvdm smpvrehtll
     1081 eglsapapms sapgeavlrs pggcpeeskv raastgrvtp lsslfslptf sllnwissws
     1141 lvsrlgsvlq fsrteqladg qagrglpvqp hsgrsglqgp dhrlligass rrsq
//
LOCUS       XP_011520131            1194 aa            linear   PRI 05-AUG-2025
DEFINITION  phospholipid-transporting ATPase VA isoform X3 [Homo sapiens].
ACCESSION   XP_011520131
VERSION     XP_011520131.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521829.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1194
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1194
                     /product="phospholipid-transporting ATPase VA isoform X3"
                     /calculated_mol_wt=132842
     Region          <1..884
                     /region_name="Haloacid Dehalogenase-like Hydrolases"
                     /note="The haloacid dehalogenase (HAD) superfamily
                     includes carbon and phosphorus hydrolases such as
                     2-haloalkonoate dehalogenase, epoxide hydrolase,
                     phosphoserine phosphatase, phosphomannomutase,
                     phosphoglycolate phosphatase, P-type ATPase, among others.
                     These...; cl21460"
                     /db_xref="CDD:473868"
     Site            order(122..126,584..585,706,725..726,729..730)
                     /site_type="active"
                     /db_xref="CDD:319770"
     CDS             1..1194
                     /gene="ATP10A"
                     /gene_synonym="ATP10C; ATPVA; ATPVC"
                     /coded_by="XM_011521829.3:155..3739"
                     /db_xref="GeneID:57194"
                     /db_xref="HGNC:HGNC:13542"
                     /db_xref="MIM:605855"
ORIGIN      
        1 mncdvlwcvl llvcmslfsa vghglwiwry qekkslfyvp ksdgsslspv taavysfltm
       61 iivlqvlipi slyvsieivk acqvyfinqd mqlydeetds qlqcralnit edlgqiqyif
      121 sdktgtlten kmvfrrctvs gveyshdana qrlaryqead seeeevvprg gsvsqrgsig
      181 shqsvrvvhr tqstkshrrt gsraeakras mlskhtafss pmekditpdp kllekvsecd
      241 kslavarhqe hllahlspel sdvfdffial ticntvvvts pdqprtkvrv rfelkspvkt
      301 iedflrrftp scltsgcssi gslaankssh klgssfpstp ssdgmllrle erlgqptsai
      361 asngyssqad nwaselaqeq eserelryea espdeaalvy aarayncvlv erlhdqvsve
      421 lphlgrltfe llhtlgfdsv rkrmsvvirh pltdeinvyt kgadsvvmdl lqpcssvdar
      481 grhqkkirsk tqnylnvyaa eglrtlciak rvlskeeyac wlqshleaes slenseellf
      541 qsairletnl hllgatgied rlqdgvpeti sklrqaglqi wvltgdkqet avniayackl
      601 ldhdeevitl natsqeacaa lldqclcyvq srglqrapek tkgkvsmrfs slcppststa
      661 sgrrpslvid grslayalek nledkflfla kqcrsvlccr stplqksmvv klvrsklkam
      721 tlaigdgand vsmiqvadvg vgisgqegmq avmasdfavp kfrylerlli lhghwcysrl
      781 anmvlyffyk ntmfvgllfw fqffcgfsas tmidqwylif fnllfsslpp lvtgvldrdv
      841 panvlltnpq lyksgqnmee yrprtfwfnm adaafqslvc fsipylayyd snvdlftwgt
      901 pivtialltf llhlgietkt wtwlnwitcg fsvllfftva liynascatc yppsnpywtm
      961 qallgdpvfy ltclmtpvaa llprlffrsl qgrvfptqlq larqltrksp rrcsapketf
     1021 aqgrlpkdsg tehssgrtvk tsvplsqpsw htqqpvcsle asgepstvdm smpvrehtll
     1081 eglsapapms sapgeavlrs pggcpeeskv raastgrvtp lsslfslptf sllnwissws
     1141 lvsrlgsvlq fsrteqladg qagrglpvqp hsgrsglqgp dhrlligass rrsq
//
LOCUS       XP_047288848            1194 aa            linear   PRI 05-AUG-2025
DEFINITION  phospholipid-transporting ATPase VA isoform X3 [Homo sapiens].
ACCESSION   XP_047288848
VERSION     XP_047288848.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432892.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1194
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1194
                     /product="phospholipid-transporting ATPase VA isoform X3"
                     /calculated_mol_wt=132842
     Region          <1..884
                     /region_name="Haloacid Dehalogenase-like Hydrolases"
                     /note="The haloacid dehalogenase (HAD) superfamily
                     includes carbon and phosphorus hydrolases such as
                     2-haloalkonoate dehalogenase, epoxide hydrolase,
                     phosphoserine phosphatase, phosphomannomutase,
                     phosphoglycolate phosphatase, P-type ATPase, among others.
                     These...; cl21460"
                     /db_xref="CDD:473868"
     Site            order(122..126,584..585,706,725..726,729..730)
                     /site_type="active"
                     /db_xref="CDD:319770"
     CDS             1..1194
                     /gene="ATP10A"
                     /gene_synonym="ATP10C; ATPVA; ATPVC"
                     /coded_by="XM_047432892.1:119..3703"
                     /db_xref="GeneID:57194"
                     /db_xref="HGNC:HGNC:13542"
                     /db_xref="MIM:605855"
ORIGIN      
        1 mncdvlwcvl llvcmslfsa vghglwiwry qekkslfyvp ksdgsslspv taavysfltm
       61 iivlqvlipi slyvsieivk acqvyfinqd mqlydeetds qlqcralnit edlgqiqyif
      121 sdktgtlten kmvfrrctvs gveyshdana qrlaryqead seeeevvprg gsvsqrgsig
      181 shqsvrvvhr tqstkshrrt gsraeakras mlskhtafss pmekditpdp kllekvsecd
      241 kslavarhqe hllahlspel sdvfdffial ticntvvvts pdqprtkvrv rfelkspvkt
      301 iedflrrftp scltsgcssi gslaankssh klgssfpstp ssdgmllrle erlgqptsai
      361 asngyssqad nwaselaqeq eserelryea espdeaalvy aarayncvlv erlhdqvsve
      421 lphlgrltfe llhtlgfdsv rkrmsvvirh pltdeinvyt kgadsvvmdl lqpcssvdar
      481 grhqkkirsk tqnylnvyaa eglrtlciak rvlskeeyac wlqshleaes slenseellf
      541 qsairletnl hllgatgied rlqdgvpeti sklrqaglqi wvltgdkqet avniayackl
      601 ldhdeevitl natsqeacaa lldqclcyvq srglqrapek tkgkvsmrfs slcppststa
      661 sgrrpslvid grslayalek nledkflfla kqcrsvlccr stplqksmvv klvrsklkam
      721 tlaigdgand vsmiqvadvg vgisgqegmq avmasdfavp kfrylerlli lhghwcysrl
      781 anmvlyffyk ntmfvgllfw fqffcgfsas tmidqwylif fnllfsslpp lvtgvldrdv
      841 panvlltnpq lyksgqnmee yrprtfwfnm adaafqslvc fsipylayyd snvdlftwgt
      901 pivtialltf llhlgietkt wtwlnwitcg fsvllfftva liynascatc yppsnpywtm
      961 qallgdpvfy ltclmtpvaa llprlffrsl qgrvfptqlq larqltrksp rrcsapketf
     1021 aqgrlpkdsg tehssgrtvk tsvplsqpsw htqqpvcsle asgepstvdm smpvrehtll
     1081 eglsapapms sapgeavlrs pggcpeeskv raastgrvtp lsslfslptf sllnwissws
     1141 lvsrlgsvlq fsrteqladg qagrglpvqp hsgrsglqgp dhrlligass rrsq
//
LOCUS       XP_047288849            1396 aa            linear   PRI 05-AUG-2025
DEFINITION  cell migration-inducing and hyaluronan-binding protein isoform X1
            [Homo sapiens].
ACCESSION   XP_047288849
VERSION     XP_047288849.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432893.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1396
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1396
                     /product="cell migration-inducing and hyaluronan-binding
                     protein isoform X1"
                     /calculated_mol_wt=156812
     Region          81..200
                     /region_name="G8"
                     /note="G8 domain; pfam10162"
                     /db_xref="CDD:462971"
     Region          176..338
                     /region_name="PANDER_like_TMEM2"
                     /note="PANDER-like domain of the transmembrane protein
                     TMEM2; cd13938"
                     /db_xref="CDD:260112"
     Region          360..438
                     /region_name="Mucin2_WxxW"
                     /note="Mucin-2 protein WxxW repeating region; pfam13330"
                     /db_xref="CDD:463846"
     Region          1240..1396
                     /region_name="PANDER_like_KIAA1199"
                     /note="PANDER-like domain of KIAA1199 and similar
                     proteins; cd13941"
                     /db_xref="CDD:260115"
     CDS             1..1396
                     /gene="CEMIP"
                     /gene_synonym="CCSP1; CEMIP1; HYBID; KIAA1199; TMEM2L"
                     /coded_by="XM_047432893.1:4950..9140"
                     /db_xref="GeneID:57214"
                     /db_xref="HGNC:HGNC:29213"
                     /db_xref="MIM:608366"
ORIGIN      
        1 mwlclspcrp cilipacqgc msdsvcfsfr ehtarmgaag rqdflfkaml tiswltltcf
       61 pgatstvaag cpdqspelqp wnpghdqdhh vhigqgktll ltssatvysi hiseggklvi
      121 kdhdepivlr trhilidngg elhagsalcp fqgnftiily gradegiqpd pyyglkyigv
      181 gkggalelhg qkklswtfln ktlhpggmae ggyfferswg hrgvivhvid pksgtvihsd
      241 rfdtyrskke serlvqylna vpdgrilsva vndegsrnld dmarkamtkl gskhflhlgf
      301 rhpwsfltvk gnpsssvedh ieyhghrgsa aarvfklfqt ehgeyfnvsl ssewvqdvew
      361 tewfdhdkvs qtkggekisd lwkahpgkic nrpidiqatt mdgvnlstev vykkgqdyrf
      421 acydrgracr syrvrflcgk pvrpkltvti dtnvnstiln lednvqswkp gdtlviastd
      481 ysmyqaeefq vlpcrscapn qvkvagkpmy lhigeeidgv dmraevglls rniivmgeme
      541 dkcypyrnhi cnffdfdtfg ghikfalgfk aahlegtelk hmgqqlvgqy pihfhlagdv
      601 derggydppt yirdlsihht fsrcvtvhgs ngllikdvvg ynslghcfft edgpeerntf
      661 dhclgllvks gtllpsdrds kmckmiteds ypgyipkprq dcnavstfwm anpnnnlinc
      721 aaagseetgf wfifhhvptg psvgmyspgy sehiplgkfy nnrahsnyra gmiidngvkt
      781 teasakdkrp flsiisarys phqdadplkp repaiirhfi ayknqdhgaw lrggdvwlds
      841 crfadngigl tlasggtfpy ddgskqeikn slfvgesgnv gtemmdnriw gpggldhsgr
      901 tlpigqnfpi rgiqlydgpi niqnctfrkf valegrhtsa lafrlnnawq scphnnvtgi
      961 afedvpitsr vffgepgpwf nqldmdgdkt svfhdvdgsv seypgsyltk ndnwlvrhpd
     1021 cinvpdwrga icsgcyaqmy iqayktsnlr mkiikndfps hplylegalt rsthyqqyqp
     1081 vvtlqkgyti hwdqtapael aiwlinfnkg dwirvglcyp rgttfsilsd vhnrllkqts
     1141 ktgvfvrtlq mdkveqsypg rshyywdeds gllflklkaq nerekfafcs mkgcerikik
     1201 alipknagvs dctataypkf teravvdvpm pkklfgsqlk tkdhflevkm esskqhffhl
     1261 wndfayievd gkkypssedg iqvvvidgnq grvvshtsfr nsilqgipwq lfnyvatipd
     1321 nsivlmaskg ryvsrgpwtr vleklgadrg lklkeqmafv gfkgsfrpiw vtldtedhka
     1381 kifqvvpipv vkkkkl
//
LOCUS       XP_047288850            1396 aa            linear   PRI 05-AUG-2025
DEFINITION  cell migration-inducing and hyaluronan-binding protein isoform X1
            [Homo sapiens].
ACCESSION   XP_047288850
VERSION     XP_047288850.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432894.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1396
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1396
                     /product="cell migration-inducing and hyaluronan-binding
                     protein isoform X1"
                     /calculated_mol_wt=156812
     Region          81..200
                     /region_name="G8"
                     /note="G8 domain; pfam10162"
                     /db_xref="CDD:462971"
     Region          176..338
                     /region_name="PANDER_like_TMEM2"
                     /note="PANDER-like domain of the transmembrane protein
                     TMEM2; cd13938"
                     /db_xref="CDD:260112"
     Region          360..438
                     /region_name="Mucin2_WxxW"
                     /note="Mucin-2 protein WxxW repeating region; pfam13330"
                     /db_xref="CDD:463846"
     Region          1240..1396
                     /region_name="PANDER_like_KIAA1199"
                     /note="PANDER-like domain of KIAA1199 and similar
                     proteins; cd13941"
                     /db_xref="CDD:260115"
     CDS             1..1396
                     /gene="CEMIP"
                     /gene_synonym="CCSP1; CEMIP1; HYBID; KIAA1199; TMEM2L"
                     /coded_by="XM_047432894.1:6293..10483"
                     /db_xref="GeneID:57214"
                     /db_xref="HGNC:HGNC:29213"
                     /db_xref="MIM:608366"
ORIGIN      
        1 mwlclspcrp cilipacqgc msdsvcfsfr ehtarmgaag rqdflfkaml tiswltltcf
       61 pgatstvaag cpdqspelqp wnpghdqdhh vhigqgktll ltssatvysi hiseggklvi
      121 kdhdepivlr trhilidngg elhagsalcp fqgnftiily gradegiqpd pyyglkyigv
      181 gkggalelhg qkklswtfln ktlhpggmae ggyfferswg hrgvivhvid pksgtvihsd
      241 rfdtyrskke serlvqylna vpdgrilsva vndegsrnld dmarkamtkl gskhflhlgf
      301 rhpwsfltvk gnpsssvedh ieyhghrgsa aarvfklfqt ehgeyfnvsl ssewvqdvew
      361 tewfdhdkvs qtkggekisd lwkahpgkic nrpidiqatt mdgvnlstev vykkgqdyrf
      421 acydrgracr syrvrflcgk pvrpkltvti dtnvnstiln lednvqswkp gdtlviastd
      481 ysmyqaeefq vlpcrscapn qvkvagkpmy lhigeeidgv dmraevglls rniivmgeme
      541 dkcypyrnhi cnffdfdtfg ghikfalgfk aahlegtelk hmgqqlvgqy pihfhlagdv
      601 derggydppt yirdlsihht fsrcvtvhgs ngllikdvvg ynslghcfft edgpeerntf
      661 dhclgllvks gtllpsdrds kmckmiteds ypgyipkprq dcnavstfwm anpnnnlinc
      721 aaagseetgf wfifhhvptg psvgmyspgy sehiplgkfy nnrahsnyra gmiidngvkt
      781 teasakdkrp flsiisarys phqdadplkp repaiirhfi ayknqdhgaw lrggdvwlds
      841 crfadngigl tlasggtfpy ddgskqeikn slfvgesgnv gtemmdnriw gpggldhsgr
      901 tlpigqnfpi rgiqlydgpi niqnctfrkf valegrhtsa lafrlnnawq scphnnvtgi
      961 afedvpitsr vffgepgpwf nqldmdgdkt svfhdvdgsv seypgsyltk ndnwlvrhpd
     1021 cinvpdwrga icsgcyaqmy iqayktsnlr mkiikndfps hplylegalt rsthyqqyqp
     1081 vvtlqkgyti hwdqtapael aiwlinfnkg dwirvglcyp rgttfsilsd vhnrllkqts
     1141 ktgvfvrtlq mdkveqsypg rshyywdeds gllflklkaq nerekfafcs mkgcerikik
     1201 alipknagvs dctataypkf teravvdvpm pkklfgsqlk tkdhflevkm esskqhffhl
     1261 wndfayievd gkkypssedg iqvvvidgnq grvvshtsfr nsilqgipwq lfnyvatipd
     1321 nsivlmaskg ryvsrgpwtr vleklgadrg lklkeqmafv gfkgsfrpiw vtldtedhka
     1381 kifqvvpipv vkkkkl
//
LOCUS       XP_047288852            1396 aa            linear   PRI 05-AUG-2025
DEFINITION  cell migration-inducing and hyaluronan-binding protein isoform X1
            [Homo sapiens].
ACCESSION   XP_047288852
VERSION     XP_047288852.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432896.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1396
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1396
                     /product="cell migration-inducing and hyaluronan-binding
                     protein isoform X1"
                     /calculated_mol_wt=156812
     Region          81..200
                     /region_name="G8"
                     /note="G8 domain; pfam10162"
                     /db_xref="CDD:462971"
     Region          176..338
                     /region_name="PANDER_like_TMEM2"
                     /note="PANDER-like domain of the transmembrane protein
                     TMEM2; cd13938"
                     /db_xref="CDD:260112"
     Region          360..438
                     /region_name="Mucin2_WxxW"
                     /note="Mucin-2 protein WxxW repeating region; pfam13330"
                     /db_xref="CDD:463846"
     Region          1240..1396
                     /region_name="PANDER_like_KIAA1199"
                     /note="PANDER-like domain of KIAA1199 and similar
                     proteins; cd13941"
                     /db_xref="CDD:260115"
     CDS             1..1396
                     /gene="CEMIP"
                     /gene_synonym="CCSP1; CEMIP1; HYBID; KIAA1199; TMEM2L"
                     /coded_by="XM_047432896.1:4855..9045"
                     /db_xref="GeneID:57214"
                     /db_xref="HGNC:HGNC:29213"
                     /db_xref="MIM:608366"
ORIGIN      
        1 mwlclspcrp cilipacqgc msdsvcfsfr ehtarmgaag rqdflfkaml tiswltltcf
       61 pgatstvaag cpdqspelqp wnpghdqdhh vhigqgktll ltssatvysi hiseggklvi
      121 kdhdepivlr trhilidngg elhagsalcp fqgnftiily gradegiqpd pyyglkyigv
      181 gkggalelhg qkklswtfln ktlhpggmae ggyfferswg hrgvivhvid pksgtvihsd
      241 rfdtyrskke serlvqylna vpdgrilsva vndegsrnld dmarkamtkl gskhflhlgf
      301 rhpwsfltvk gnpsssvedh ieyhghrgsa aarvfklfqt ehgeyfnvsl ssewvqdvew
      361 tewfdhdkvs qtkggekisd lwkahpgkic nrpidiqatt mdgvnlstev vykkgqdyrf
      421 acydrgracr syrvrflcgk pvrpkltvti dtnvnstiln lednvqswkp gdtlviastd
      481 ysmyqaeefq vlpcrscapn qvkvagkpmy lhigeeidgv dmraevglls rniivmgeme
      541 dkcypyrnhi cnffdfdtfg ghikfalgfk aahlegtelk hmgqqlvgqy pihfhlagdv
      601 derggydppt yirdlsihht fsrcvtvhgs ngllikdvvg ynslghcfft edgpeerntf
      661 dhclgllvks gtllpsdrds kmckmiteds ypgyipkprq dcnavstfwm anpnnnlinc
      721 aaagseetgf wfifhhvptg psvgmyspgy sehiplgkfy nnrahsnyra gmiidngvkt
      781 teasakdkrp flsiisarys phqdadplkp repaiirhfi ayknqdhgaw lrggdvwlds
      841 crfadngigl tlasggtfpy ddgskqeikn slfvgesgnv gtemmdnriw gpggldhsgr
      901 tlpigqnfpi rgiqlydgpi niqnctfrkf valegrhtsa lafrlnnawq scphnnvtgi
      961 afedvpitsr vffgepgpwf nqldmdgdkt svfhdvdgsv seypgsyltk ndnwlvrhpd
     1021 cinvpdwrga icsgcyaqmy iqayktsnlr mkiikndfps hplylegalt rsthyqqyqp
     1081 vvtlqkgyti hwdqtapael aiwlinfnkg dwirvglcyp rgttfsilsd vhnrllkqts
     1141 ktgvfvrtlq mdkveqsypg rshyywdeds gllflklkaq nerekfafcs mkgcerikik
     1201 alipknagvs dctataypkf teravvdvpm pkklfgsqlk tkdhflevkm esskqhffhl
     1261 wndfayievd gkkypssedg iqvvvidgnq grvvshtsfr nsilqgipwq lfnyvatipd
     1321 nsivlmaskg ryvsrgpwtr vleklgadrg lklkeqmafv gfkgsfrpiw vtldtedhka
     1381 kifqvvpipv vkkkkl
//
LOCUS       XP_047288853            1396 aa            linear   PRI 05-AUG-2025
DEFINITION  cell migration-inducing and hyaluronan-binding protein isoform X1
            [Homo sapiens].
ACCESSION   XP_047288853
VERSION     XP_047288853.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432897.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1396
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1396
                     /product="cell migration-inducing and hyaluronan-binding
                     protein isoform X1"
                     /calculated_mol_wt=156812
     Region          81..200
                     /region_name="G8"
                     /note="G8 domain; pfam10162"
                     /db_xref="CDD:462971"
     Region          176..338
                     /region_name="PANDER_like_TMEM2"
                     /note="PANDER-like domain of the transmembrane protein
                     TMEM2; cd13938"
                     /db_xref="CDD:260112"
     Region          360..438
                     /region_name="Mucin2_WxxW"
                     /note="Mucin-2 protein WxxW repeating region; pfam13330"
                     /db_xref="CDD:463846"
     Region          1240..1396
                     /region_name="PANDER_like_KIAA1199"
                     /note="PANDER-like domain of KIAA1199 and similar
                     proteins; cd13941"
                     /db_xref="CDD:260115"
     CDS             1..1396
                     /gene="CEMIP"
                     /gene_synonym="CCSP1; CEMIP1; HYBID; KIAA1199; TMEM2L"
                     /coded_by="XM_047432897.1:6198..10388"
                     /db_xref="GeneID:57214"
                     /db_xref="HGNC:HGNC:29213"
                     /db_xref="MIM:608366"
ORIGIN      
        1 mwlclspcrp cilipacqgc msdsvcfsfr ehtarmgaag rqdflfkaml tiswltltcf
       61 pgatstvaag cpdqspelqp wnpghdqdhh vhigqgktll ltssatvysi hiseggklvi
      121 kdhdepivlr trhilidngg elhagsalcp fqgnftiily gradegiqpd pyyglkyigv
      181 gkggalelhg qkklswtfln ktlhpggmae ggyfferswg hrgvivhvid pksgtvihsd
      241 rfdtyrskke serlvqylna vpdgrilsva vndegsrnld dmarkamtkl gskhflhlgf
      301 rhpwsfltvk gnpsssvedh ieyhghrgsa aarvfklfqt ehgeyfnvsl ssewvqdvew
      361 tewfdhdkvs qtkggekisd lwkahpgkic nrpidiqatt mdgvnlstev vykkgqdyrf
      421 acydrgracr syrvrflcgk pvrpkltvti dtnvnstiln lednvqswkp gdtlviastd
      481 ysmyqaeefq vlpcrscapn qvkvagkpmy lhigeeidgv dmraevglls rniivmgeme
      541 dkcypyrnhi cnffdfdtfg ghikfalgfk aahlegtelk hmgqqlvgqy pihfhlagdv
      601 derggydppt yirdlsihht fsrcvtvhgs ngllikdvvg ynslghcfft edgpeerntf
      661 dhclgllvks gtllpsdrds kmckmiteds ypgyipkprq dcnavstfwm anpnnnlinc
      721 aaagseetgf wfifhhvptg psvgmyspgy sehiplgkfy nnrahsnyra gmiidngvkt
      781 teasakdkrp flsiisarys phqdadplkp repaiirhfi ayknqdhgaw lrggdvwlds
      841 crfadngigl tlasggtfpy ddgskqeikn slfvgesgnv gtemmdnriw gpggldhsgr
      901 tlpigqnfpi rgiqlydgpi niqnctfrkf valegrhtsa lafrlnnawq scphnnvtgi
      961 afedvpitsr vffgepgpwf nqldmdgdkt svfhdvdgsv seypgsyltk ndnwlvrhpd
     1021 cinvpdwrga icsgcyaqmy iqayktsnlr mkiikndfps hplylegalt rsthyqqyqp
     1081 vvtlqkgyti hwdqtapael aiwlinfnkg dwirvglcyp rgttfsilsd vhnrllkqts
     1141 ktgvfvrtlq mdkveqsypg rshyywdeds gllflklkaq nerekfafcs mkgcerikik
     1201 alipknagvs dctataypkf teravvdvpm pkklfgsqlk tkdhflevkm esskqhffhl
     1261 wndfayievd gkkypssedg iqvvvidgnq grvvshtsfr nsilqgipwq lfnyvatipd
     1321 nsivlmaskg ryvsrgpwtr vleklgadrg lklkeqmafv gfkgsfrpiw vtldtedhka
     1381 kifqvvpipv vkkkkl
//
LOCUS       XP_047288854            1396 aa            linear   PRI 05-AUG-2025
DEFINITION  cell migration-inducing and hyaluronan-binding protein isoform X1
            [Homo sapiens].
ACCESSION   XP_047288854
VERSION     XP_047288854.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432898.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1396
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1396
                     /product="cell migration-inducing and hyaluronan-binding
                     protein isoform X1"
                     /calculated_mol_wt=156812
     Region          81..200
                     /region_name="G8"
                     /note="G8 domain; pfam10162"
                     /db_xref="CDD:462971"
     Region          176..338
                     /region_name="PANDER_like_TMEM2"
                     /note="PANDER-like domain of the transmembrane protein
                     TMEM2; cd13938"
                     /db_xref="CDD:260112"
     Region          360..438
                     /region_name="Mucin2_WxxW"
                     /note="Mucin-2 protein WxxW repeating region; pfam13330"
                     /db_xref="CDD:463846"
     Region          1240..1396
                     /region_name="PANDER_like_KIAA1199"
                     /note="PANDER-like domain of KIAA1199 and similar
                     proteins; cd13941"
                     /db_xref="CDD:260115"
     CDS             1..1396
                     /gene="CEMIP"
                     /gene_synonym="CCSP1; CEMIP1; HYBID; KIAA1199; TMEM2L"
                     /coded_by="XM_047432898.1:5473..9663"
                     /db_xref="GeneID:57214"
                     /db_xref="HGNC:HGNC:29213"
                     /db_xref="MIM:608366"
ORIGIN      
        1 mwlclspcrp cilipacqgc msdsvcfsfr ehtarmgaag rqdflfkaml tiswltltcf
       61 pgatstvaag cpdqspelqp wnpghdqdhh vhigqgktll ltssatvysi hiseggklvi
      121 kdhdepivlr trhilidngg elhagsalcp fqgnftiily gradegiqpd pyyglkyigv
      181 gkggalelhg qkklswtfln ktlhpggmae ggyfferswg hrgvivhvid pksgtvihsd
      241 rfdtyrskke serlvqylna vpdgrilsva vndegsrnld dmarkamtkl gskhflhlgf
      301 rhpwsfltvk gnpsssvedh ieyhghrgsa aarvfklfqt ehgeyfnvsl ssewvqdvew
      361 tewfdhdkvs qtkggekisd lwkahpgkic nrpidiqatt mdgvnlstev vykkgqdyrf
      421 acydrgracr syrvrflcgk pvrpkltvti dtnvnstiln lednvqswkp gdtlviastd
      481 ysmyqaeefq vlpcrscapn qvkvagkpmy lhigeeidgv dmraevglls rniivmgeme
      541 dkcypyrnhi cnffdfdtfg ghikfalgfk aahlegtelk hmgqqlvgqy pihfhlagdv
      601 derggydppt yirdlsihht fsrcvtvhgs ngllikdvvg ynslghcfft edgpeerntf
      661 dhclgllvks gtllpsdrds kmckmiteds ypgyipkprq dcnavstfwm anpnnnlinc
      721 aaagseetgf wfifhhvptg psvgmyspgy sehiplgkfy nnrahsnyra gmiidngvkt
      781 teasakdkrp flsiisarys phqdadplkp repaiirhfi ayknqdhgaw lrggdvwlds
      841 crfadngigl tlasggtfpy ddgskqeikn slfvgesgnv gtemmdnriw gpggldhsgr
      901 tlpigqnfpi rgiqlydgpi niqnctfrkf valegrhtsa lafrlnnawq scphnnvtgi
      961 afedvpitsr vffgepgpwf nqldmdgdkt svfhdvdgsv seypgsyltk ndnwlvrhpd
     1021 cinvpdwrga icsgcyaqmy iqayktsnlr mkiikndfps hplylegalt rsthyqqyqp
     1081 vvtlqkgyti hwdqtapael aiwlinfnkg dwirvglcyp rgttfsilsd vhnrllkqts
     1141 ktgvfvrtlq mdkveqsypg rshyywdeds gllflklkaq nerekfafcs mkgcerikik
     1201 alipknagvs dctataypkf teravvdvpm pkklfgsqlk tkdhflevkm esskqhffhl
     1261 wndfayievd gkkypssedg iqvvvidgnq grvvshtsfr nsilqgipwq lfnyvatipd
     1321 nsivlmaskg ryvsrgpwtr vleklgadrg lklkeqmafv gfkgsfrpiw vtldtedhka
     1381 kifqvvpipv vkkkkl
//
LOCUS       XP_047288855            1396 aa            linear   PRI 05-AUG-2025
DEFINITION  cell migration-inducing and hyaluronan-binding protein isoform X1
            [Homo sapiens].
ACCESSION   XP_047288855
VERSION     XP_047288855.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432899.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1396
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1396
                     /product="cell migration-inducing and hyaluronan-binding
                     protein isoform X1"
                     /calculated_mol_wt=156812
     Region          81..200
                     /region_name="G8"
                     /note="G8 domain; pfam10162"
                     /db_xref="CDD:462971"
     Region          176..338
                     /region_name="PANDER_like_TMEM2"
                     /note="PANDER-like domain of the transmembrane protein
                     TMEM2; cd13938"
                     /db_xref="CDD:260112"
     Region          360..438
                     /region_name="Mucin2_WxxW"
                     /note="Mucin-2 protein WxxW repeating region; pfam13330"
                     /db_xref="CDD:463846"
     Region          1240..1396
                     /region_name="PANDER_like_KIAA1199"
                     /note="PANDER-like domain of KIAA1199 and similar
                     proteins; cd13941"
                     /db_xref="CDD:260115"
     CDS             1..1396
                     /gene="CEMIP"
                     /gene_synonym="CCSP1; CEMIP1; HYBID; KIAA1199; TMEM2L"
                     /coded_by="XM_047432899.1:483..4673"
                     /db_xref="GeneID:57214"
                     /db_xref="HGNC:HGNC:29213"
                     /db_xref="MIM:608366"
ORIGIN      
        1 mwlclspcrp cilipacqgc msdsvcfsfr ehtarmgaag rqdflfkaml tiswltltcf
       61 pgatstvaag cpdqspelqp wnpghdqdhh vhigqgktll ltssatvysi hiseggklvi
      121 kdhdepivlr trhilidngg elhagsalcp fqgnftiily gradegiqpd pyyglkyigv
      181 gkggalelhg qkklswtfln ktlhpggmae ggyfferswg hrgvivhvid pksgtvihsd
      241 rfdtyrskke serlvqylna vpdgrilsva vndegsrnld dmarkamtkl gskhflhlgf
      301 rhpwsfltvk gnpsssvedh ieyhghrgsa aarvfklfqt ehgeyfnvsl ssewvqdvew
      361 tewfdhdkvs qtkggekisd lwkahpgkic nrpidiqatt mdgvnlstev vykkgqdyrf
      421 acydrgracr syrvrflcgk pvrpkltvti dtnvnstiln lednvqswkp gdtlviastd
      481 ysmyqaeefq vlpcrscapn qvkvagkpmy lhigeeidgv dmraevglls rniivmgeme
      541 dkcypyrnhi cnffdfdtfg ghikfalgfk aahlegtelk hmgqqlvgqy pihfhlagdv
      601 derggydppt yirdlsihht fsrcvtvhgs ngllikdvvg ynslghcfft edgpeerntf
      661 dhclgllvks gtllpsdrds kmckmiteds ypgyipkprq dcnavstfwm anpnnnlinc
      721 aaagseetgf wfifhhvptg psvgmyspgy sehiplgkfy nnrahsnyra gmiidngvkt
      781 teasakdkrp flsiisarys phqdadplkp repaiirhfi ayknqdhgaw lrggdvwlds
      841 crfadngigl tlasggtfpy ddgskqeikn slfvgesgnv gtemmdnriw gpggldhsgr
      901 tlpigqnfpi rgiqlydgpi niqnctfrkf valegrhtsa lafrlnnawq scphnnvtgi
      961 afedvpitsr vffgepgpwf nqldmdgdkt svfhdvdgsv seypgsyltk ndnwlvrhpd
     1021 cinvpdwrga icsgcyaqmy iqayktsnlr mkiikndfps hplylegalt rsthyqqyqp
     1081 vvtlqkgyti hwdqtapael aiwlinfnkg dwirvglcyp rgttfsilsd vhnrllkqts
     1141 ktgvfvrtlq mdkveqsypg rshyywdeds gllflklkaq nerekfafcs mkgcerikik
     1201 alipknagvs dctataypkf teravvdvpm pkklfgsqlk tkdhflevkm esskqhffhl
     1261 wndfayievd gkkypssedg iqvvvidgnq grvvshtsfr nsilqgipwq lfnyvatipd
     1321 nsivlmaskg ryvsrgpwtr vleklgadrg lklkeqmafv gfkgsfrpiw vtldtedhka
     1381 kifqvvpipv vkkkkl
//
LOCUS       XP_047288856            1361 aa            linear   PRI 05-AUG-2025
DEFINITION  cell migration-inducing and hyaluronan-binding protein isoform X2
            [Homo sapiens].
ACCESSION   XP_047288856
VERSION     XP_047288856.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432900.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1361
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1361
                     /product="cell migration-inducing and hyaluronan-binding
                     protein isoform X2"
                     /calculated_mol_wt=152867
     Region          46..165
                     /region_name="G8"
                     /note="G8 domain; pfam10162"
                     /db_xref="CDD:462971"
     Region          141..303
                     /region_name="PANDER_like_TMEM2"
                     /note="PANDER-like domain of the transmembrane protein
                     TMEM2; cd13938"
                     /db_xref="CDD:260112"
     Region          325..403
                     /region_name="Mucin2_WxxW"
                     /note="Mucin-2 protein WxxW repeating region; pfam13330"
                     /db_xref="CDD:463846"
     Region          1205..1361
                     /region_name="PANDER_like_KIAA1199"
                     /note="PANDER-like domain of KIAA1199 and similar
                     proteins; cd13941"
                     /db_xref="CDD:260115"
     CDS             1..1361
                     /gene="CEMIP"
                     /gene_synonym="CCSP1; CEMIP1; HYBID; KIAA1199; TMEM2L"
                     /coded_by="XM_047432900.1:4828..8913"
                     /db_xref="GeneID:57214"
                     /db_xref="HGNC:HGNC:29213"
                     /db_xref="MIM:608366"
ORIGIN      
        1 mgaagrqdfl fkamltiswl tltcfpgats tvaagcpdqs pelqpwnpgh dqdhhvhigq
       61 gktllltssa tvysihiseg gklvikdhde pivlrtrhil idnggelhag salcpfqgnf
      121 tiilygrade giqpdpyygl kyigvgkgga lelhgqkkls wtflnktlhp ggmaeggyff
      181 erswghrgvi vhvidpksgt vihsdrfdty rskkeserlv qylnavpdgr ilsvavndeg
      241 srnlddmark amtklgskhf lhlgfrhpws fltvkgnpss svedhieyhg hrgsaaarvf
      301 klfqtehgey fnvslssewv qdvewtewfd hdkvsqtkgg ekisdlwkah pgkicnrpid
      361 iqattmdgvn lstevvykkg qdyrfacydr gracrsyrvr flcgkpvrpk ltvtidtnvn
      421 stilnlednv qswkpgdtlv iastdysmyq aeefqvlpcr scapnqvkva gkpmylhige
      481 eidgvdmrae vgllsrniiv mgemedkcyp yrnhicnffd fdtfgghikf algfkaahle
      541 gtelkhmgqq lvgqypihfh lagdvdergg ydpptyirdl sihhtfsrcv tvhgsnglli
      601 kdvvgynslg hcfftedgpe erntfdhclg llvksgtllp sdrdskmckm itedsypgyi
      661 pkprqdcnav stfwmanpnn nlincaaags eetgfwfifh hvptgpsvgm yspgysehip
      721 lgkfynnrah snyragmiid ngvktteasa kdkrpflsii sarysphqda dplkprepai
      781 irhfiayknq dhgawlrggd vwldscrfad ngigltlasg gtfpyddgsk qeiknslfvg
      841 esgnvgtemm dnriwgpggl dhsgrtlpig qnfpirgiql ydgpiniqnc tfrkfvaleg
      901 rhtsalafrl nnawqscphn nvtgiafedv pitsrvffge pgpwfnqldm dgdktsvfhd
      961 vdgsvseypg syltkndnwl vrhpdcinvp dwrgaicsgc yaqmyiqayk tsnlrmkiik
     1021 ndfpshplyl egaltrsthy qqyqpvvtlq kgytihwdqt apaelaiwli nfnkgdwirv
     1081 glcyprgttf silsdvhnrl lkqtsktgvf vrtlqmdkve qsypgrshyy wdedsgllfl
     1141 klkaqnerek fafcsmkgce rikikalipk nagvsdctat aypkfterav vdvpmpkklf
     1201 gsqlktkdhf levkmesskq hffhlwndfa yievdgkkyp ssedgiqvvv idgnqgrvvs
     1261 htsfrnsilq gipwqlfnyv atipdnsivl maskgryvsr gpwtrvlekl gadrglklke
     1321 qmafvgfkgs frpiwvtldt edhkakifqv vpipvvkkkk l
//
LOCUS       XP_016877927             270 aa            linear   PRI 05-AUG-2025
DEFINITION  gap junction delta-2 protein isoform X1 [Homo sapiens].
ACCESSION   XP_016877927
VERSION     XP_016877927.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022438.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..270
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..270
                     /product="gap junction delta-2 protein isoform X1"
                     /calculated_mol_wt=30195
     Region          <1..226
                     /region_name="Connexin"
                     /note="pfam00029"
                     /db_xref="CDD:459638"
     CDS             1..270
                     /gene="GJD2"
                     /gene_synonym="CX36; GJA9"
                     /coded_by="XM_017022438.2:346..1158"
                     /db_xref="GeneID:57369"
                     /db_xref="HGNC:HGNC:19154"
                     /db_xref="MIM:607058"
ORIGIN      
        1 mfvcntlqpg cnqacydraf pishirywvf qiimvctpsl cfitysvhqs akqrerryst
       61 vflaldrdpp esiggpggtg gggsgggkre dkklqnaivn gvlqntents ketepdclev
      121 keltphpsgl rtasksklrr qegisrfyii qvvfrnalei gflvgqyfly gfsvpglyec
      181 nrypcikeve cyvsrptekt vflvfmfavs gicvvlnlae lnhlgwrkik lavrgaqakr
      241 ksiyeirnkd lprvsvpnfg rtqssdsayv
//
LOCUS       XP_011520133            4705 aa            linear   PRI 05-AUG-2025
DEFINITION  stAR-related lipid transfer protein 9 isoform X1 [Homo sapiens].
ACCESSION   XP_011520133
VERSION     XP_011520133.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521831.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4705
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4705
                     /product="stAR-related lipid transfer protein 9 isoform
                     X1"
                     /calculated_mol_wt=516694
     Region          2..391
                     /region_name="KISc_KIF1A_KIF1B"
                     /note="Kinesin motor domain, KIF1_like proteins; cd01365"
                     /db_xref="CDD:276816"
     Site            order(11,103,106,108..111,253)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276816"
     Site            order(337,340,343)
                     /site_type="other"
                     /note="microtubule interaction site [polypeptide binding]"
                     /db_xref="CDD:276816"
     Region          390..501
                     /region_name="Kinesin_assoc"
                     /note="Kinesin-associated; pfam16183"
                     /db_xref="CDD:465047"
     Region          471..589
                     /region_name="FHA_KIF16A_STARD9"
                     /note="forkhead associated (FHA) domain found in
                     StAR-related lipid transfer protein 9 (StARD9); cd22731"
                     /db_xref="CDD:438783"
     Region          <580..>786
                     /region_name="COG4913"
                     /note="Uncharacterized conserved protein, contains a
                     C-terminal ATPase domain [Function unknown]"
                     /db_xref="CDD:443941"
     Region          4496..4705
                     /region_name="START_STARD9-like"
                     /note="C-terminal START domain of mammalian STARD9, and
                     related domains; lipid binding; cd08874"
                     /db_xref="CDD:176883"
     Site            order(4522..4523,4530,4542,4544,4555,4559,4565,4568..4569,
                     4571..4572,4591,4593..4596,4600,4603,4605,4607,4627,4645,
                     4647..4650,4652,4667,4669,4671,4673,4675,4677,4680,
                     4682..4684,4688..4689,4693..4694,4697)
                     /site_type="other"
                     /note="putative lipid binding site [chemical binding]"
                     /db_xref="CDD:176883"
     CDS             1..4705
                     /gene="STARD9"
                     /gene_synonym="KIF16A"
                     /coded_by="XM_011521831.4:111..14228"
                     /db_xref="GeneID:57519"
                     /db_xref="HGNC:HGNC:19162"
                     /db_xref="MIM:614642"
ORIGIN      
        1 manvqvavrv rplskretke ggriivevdg kvakirnlkv dnrpdgfgds rekvmafgfd
       61 ycywsvnped pqyasqdvvf qdlgmevlsg vakgyniclf aygqtgsgkt ytmlgtpasv
      121 gltpricegl fvrekdcasl psscrikvsf leiynervrd llkqsgqkks ytlrvrehpe
      181 mgpyvqglsq hvvtnykqvi qlleegianr itaathvhea ssrshaifti hytqailenn
      241 lpsemaskin lvdlagsera dpsyckdria eganinkslv tlgivistla qnsqvfsscq
      301 slnssvsngg dsgilsspsg tssggapsrr qsyipyrdsv ltwllkdslg gnsktimvat
      361 vspahtsyse tmstlryass akniinkprv nedanlklir elreeierlk alllsfelrn
      421 fsslsdenlk elvlqnelki dqltkdwtqk wndwqalmeh ysvdinrrra gvvidsslph
      481 lmaleddvls tgvvlyhlke gttkigrids dqeqdivlqg qwierdhcti tsacgvvvlr
      541 pargarctvn grevtascrl tqgavitlgk aqkfrfnhpa eaavlrqrrq vgeaaagrgs
      601 lewldldgdl aasrlglspl lwkerralee qcdedhqtpr dgetshraqi qqqqsyvedl
      661 rhqilaeeir aakelefdqa wisqqikenq qcllreetwl aslqqqqqed qvaekeleas
      721 valdawlqtd peiqpspfvq sqkrvvhlql lrrhtlraae rnvrrkkvsf qleriikkqr
      781 lleaqkrlek lttlcwlqdd stqeppyqvl spdatvprpp crskltscss lspqrlcskh
      841 mpqlhsifls wdpsttlppr pdpthqtsek tsseehlpqa asypartgcl rknglhssgh
      901 gqpctaraal arkgasapda cltmspnsvg iqememgvkq phqmvsqgla slrksanklk
      961 prhepkifts ttqtrgakgl adpshtqagw rkegnlgthk aakgascnsl yphgprqtag
     1021 hgkavktfwt eykppspsra skrhqrvlat rvrnitkkss hlplgsplkr qqntrdpdtm
     1081 vpltdfspvm dhsrekdndl sdtdsnysld slscvyakal ieplkpeerk wdfpepense
     1141 sddsqlseds laekryqspk nrlggnrptn nrgqprtrtr asvrgftaas dsdllaqthr
     1201 sfsldslida eeelgedqqe epfpgsadei ptetfwhled sslpvmdqea icrlgpinyr
     1261 taarldavlp msssfyldpq fqphcelqph celqphcelq phceqaesqv epsyseqads
     1321 lqgmqlsres plmsmdswfs cdskinpssp pgivgslcps pdmqefhsck gerpgywpnt
     1381 eelkpsdaet vlpyssklhq gstellcsar dehtasaadt srlslwgiqr liqpgadgtf
     1441 qgrcipdmtq qgsseashns svsnvlaasa ttlthvgsth erdwsalqqk yllelscpvl
     1501 eaigapkpay pyleedsgsl aqasskggdt llpvgprvss nlnlnnfpvh lsrirrlrae
     1561 keqdslnakl egvsdffsts ekeasydety sadleslsas rstnaqvfat enaipdsmte
     1621 acevkqnnle eclqscrkpg lmtssdedff qknachsnvt tatkadhwsq gwaplrknsa
     1681 vqpgqlspds hypleeektd cqesskeavr rhinvsfalp sgpelylhsa pwnplssslq
     1741 pplletfyvt ksrdalteta leipacrevr vpspppreaw gfghnhqalq gaylknnlpv
     1801 llqnqnskia ssqqvtaeip vdlntrevir esgkcpgnit eeshdsvyss vtqnrhflps
     1861 tstkvcefen qvvilnkkhs fpaleggevt aqsccgassd stesgksllf researeeee
     1921 ldqntvlrqt invslekdmp gesavslksr svdrrvsspv mvaqgggptp kwegknetgl
     1981 lekglrpkds seefklpgtk payerfqlva cpqernpsec ksqemlnpnr epsgkkqnkr
     2041 vnntdemarl irsvmqleng ileieskqnk qvhashtpgt dkelvfqdqk eqektdhafr
     2101 pdssgnplps kdqpssprqt ddtvfrdsea gamevnsign hpqvqkitpn pfrsregvre
     2161 sepvrehthp agsdrpardi cdslgkhttc reftntslhp qrmkalaral plqprlerss
     2221 knngqfvkas aslkgqpwgl gsleeletvk gfqesqvaeh vsssnqeepk aqgkveempm
     2281 qrggslqeen kvtqkfpsls qlcrdtffrq etvspllsrt efctaplhqd lsntlplnsp
     2341 rwprrclhvp valgissldc vldltmlkih nsplvtgveh qdqstetrsh spegnvrgrs
     2401 seahtawcgs vrsmamgshs qsgvpesipl gtedrisast spqdhgkdlr itllgfstse
     2461 dfaseaevav qkeirvssln kvssqpekrv sfsleedsdq askprqkaek etedvgltsg
     2521 vslapvslpr vpspeprlle psdhasmcla ileeirqaka qrkqlhdfva rgtvlsycet
     2581 llepecssrv agrpqckqid qsssdqtrne geapgfhvas lsaeagqidl lpderkvqat
     2641 slsadsfesl pntetdrepw dpvqafshaa paqdrkrrtg elrqfagase pfichsssse
     2701 iiekkkdatr tpssadplap dsprssapve evrrvvskkv vaalpsqapy ddprvtlhel
     2761 sqsvpqetae gippgsqdss pehqeprtld ttygevsdnl lvtaqgekta hfesqsvtcd
     2821 vqnstsasgp kqdhvqcpea stgfeegras pkqdtilpga ltrvaleapt qqcvqckesv
     2881 gsgltevcra gskhsrpipl pdqrpsanpg gigeeapcrh prealdgpvf srnpegsrtl
     2941 spsrgkesrt lpcrqpcssq pvathayssh sstllcfrdg dlgkepfkaa phtihppcvv
     3001 psrayemdet geisrgpdvh lthglepkdv nrefrltess tcepstvaav lsraqgcrsp
     3061 sapdvrtgsf shsatdgsvg ligvpekkva ekqastelea asfpagmyse plrqfrdssv
     3121 gdqnaqvcqt npeppattqg phtldlsegs aesklvvepq heclenttrc flekpqfste
     3181 lrdhnrldsq akfvarlkht cspqedspwq eeeqhrdqas gggegfaqgv nplpdedgld
     3241 gcqildagre evavakppvs kilsqgfkdp atvslrqnet pqpaaqrsgh lytgreqpap
     3301 nhrgslpvtt ifsgpkhsrs sptpqfsvvg ssrslqelnl sveppsptde dtqgpnrlwn
     3361 phlrgyssgk svartslqae dsnqkassrl ddgttdhrhl kpatppypmp stlshmptpd
     3421 fttswmsgtl eqaqqgkrek lgvqvrpenw csqmdkgmlh fgssdispya lpwrpeepar
     3481 iswkqymsgs avdvscsqkp qgltlsnvar cssmdngled qnspfhshls tyanicdlst
     3541 thsstenaqg sneawevfrg sssialgdph iptspegvap tsghdrrpqf rgpsgeadcl
     3601 rskpplakgs aagpvdeiml lypseagcpv gqtrtntfeq gtqtlgsrrh wsstdisfaq
     3661 peasavsafd laswtsmhnl slhlsqllhs tsellgslsq pdvarreqnt krdipdkapq
     3721 almmdgstqt tvdegsqtdl tlptlclqts eaepqganvi leglgsdtst vsqeegdvpg
     3781 vpqkreaeet aqkmaqllyl qeestpykpq spsipsshlr fqkapvgqhl psvspsvsda
     3841 flppssqpee syclvvssps pssphspglf pstseypgds rvqkklgpts alfvdrassp
     3901 iltlsastqe pglspgsltl sapsthpveg hqkldsspdp vdaprtpmdn ysqttdelgg
     3961 sqrgrsslqr sngrsflelh sphspqqspk lqfsflgqhp qqlqprttig vqsrllpppl
     4021 rhrsqrlgns fvpekvaspe hcplsgreps qwqsrtengg essaspgepq rtldrpsswg
     4081 glqhlspcpv seltdtaglr gsalglpqac qpeellcfsc qmcmapehqh hslrdlpvhn
     4141 kfsnwcgvqk gspggldmte eelgasgdls sekqeqsppq ppndhsqdse wskreqiplq
     4201 vgaqnlslsv elteaklhhg fgeadallqv lqsgtgeala adepvtstwk elyarqkkai
     4261 etlrreraer lgnfcrtrsl spqkqlsllp nkdlfiwdld lpsrrreylq qlrkdvvett
     4321 rspesvsrsa htpsdielml qdyqqaheea kveiarardq lrerteqekl rihqkiisql
     4381 lkeedklhtl anssslctss ngslssgmts gynsspalsg qlqfpenmgh tnlpdsrdvw
     4441 igdergghsa vrknsayshr aslgscccsp sslsslgtcf sssyqdlakh vvdtsmadvm
     4501 aacsdnlhnl fscqatagwn yqgeeqavql yykvfsptrh gflgagvvsq plsrvwaavs
     4561 dptvwplyyk piqtarlhqr vtnsislvyl vcnttlcalk qprdfccvcv eakevpalvg
     4621 hlsvmaaqsv ydtsmprpsr kmvrgeilps awilqpitve gkevtrviyl aqvelgapgf
     4681 ppqllssfik rqplviarla sflgr
//
LOCUS       XP_011520134            4704 aa            linear   PRI 05-AUG-2025
DEFINITION  stAR-related lipid transfer protein 9 isoform X2 [Homo sapiens].
ACCESSION   XP_011520134
VERSION     XP_011520134.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521832.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4704
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4704
                     /product="stAR-related lipid transfer protein 9 isoform
                     X2"
                     /calculated_mol_wt=516595
     Region          2..390
                     /region_name="KISc_KIF1A_KIF1B"
                     /note="Kinesin motor domain, KIF1_like proteins; cd01365"
                     /db_xref="CDD:276816"
     Site            order(11,102,105,107..110,252)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276816"
     Site            order(336,339,342)
                     /site_type="other"
                     /note="microtubule interaction site [polypeptide binding]"
                     /db_xref="CDD:276816"
     Region          389..500
                     /region_name="Kinesin_assoc"
                     /note="Kinesin-associated; pfam16183"
                     /db_xref="CDD:465047"
     Region          470..588
                     /region_name="FHA_KIF16A_STARD9"
                     /note="forkhead associated (FHA) domain found in
                     StAR-related lipid transfer protein 9 (StARD9); cd22731"
                     /db_xref="CDD:438783"
     Region          <579..>785
                     /region_name="COG4913"
                     /note="Uncharacterized conserved protein, contains a
                     C-terminal ATPase domain [Function unknown]"
                     /db_xref="CDD:443941"
     Region          4495..4704
                     /region_name="START_STARD9-like"
                     /note="C-terminal START domain of mammalian STARD9, and
                     related domains; lipid binding; cd08874"
                     /db_xref="CDD:176883"
     Site            order(4521..4522,4529,4541,4543,4554,4558,4564,4567..4568,
                     4570..4571,4590,4592..4595,4599,4602,4604,4606,4626,4644,
                     4646..4649,4651,4666,4668,4670,4672,4674,4676,4679,
                     4681..4683,4687..4688,4692..4693,4696)
                     /site_type="other"
                     /note="putative lipid binding site [chemical binding]"
                     /db_xref="CDD:176883"
     CDS             1..4704
                     /gene="STARD9"
                     /gene_synonym="KIF16A"
                     /coded_by="XM_011521832.3:111..14225"
                     /db_xref="GeneID:57519"
                     /db_xref="HGNC:HGNC:19162"
                     /db_xref="MIM:614642"
ORIGIN      
        1 manvqvavrv rplskretke ggriivevdg kvakirnlkv dnrpdgfgds rekvmafgfd
       61 ycywsvnped pqyasqdvfq dlgmevlsgv akgyniclfa ygqtgsgkty tmlgtpasvg
      121 ltpriceglf vrekdcaslp sscrikvsfl eiynervrdl lkqsgqkksy tlrvrehpem
      181 gpyvqglsqh vvtnykqviq lleegianri taathvheas srshaiftih ytqailennl
      241 psemaskinl vdlagserad psyckdriae ganinkslvt lgivistlaq nsqvfsscqs
      301 lnssvsnggd sgilsspsgt ssggapsrrq syipyrdsvl twllkdslgg nsktimvatv
      361 spahtsyset mstlryassa kniinkprvn edanlklire lreeierlka lllsfelrnf
      421 sslsdenlke lvlqnelkid qltkdwtqkw ndwqalmehy svdinrrrag vvidsslphl
      481 maleddvlst gvvlyhlkeg ttkigridsd qeqdivlqgq wierdhctit sacgvvvlrp
      541 argarctvng revtascrlt qgavitlgka qkfrfnhpae aavlrqrrqv geaaagrgsl
      601 ewldldgdla asrlglspll wkerraleeq cdedhqtprd getshraqiq qqqsyvedlr
      661 hqilaeeira akelefdqaw isqqikenqq cllreetwla slqqqqqedq vaekeleasv
      721 aldawlqtdp eiqpspfvqs qkrvvhlqll rrhtlraaer nvrrkkvsfq leriikkqrl
      781 leaqkrlekl ttlcwlqdds tqeppyqvls pdatvprppc rskltscssl spqrlcskhm
      841 pqlhsiflsw dpsttlpprp dpthqtsekt sseehlpqaa sypartgclr knglhssghg
      901 qpctaraala rkgasapdac ltmspnsvgi qememgvkqp hqmvsqglas lrksanklkp
      961 rhepkiftst tqtrgakgla dpshtqagwr kegnlgthka akgascnsly phgprqtagh
     1021 gkavktfwte ykppspsras krhqrvlatr vrnitkkssh lplgsplkrq qntrdpdtmv
     1081 pltdfspvmd hsrekdndls dtdsnyslds lscvyakali eplkpeerkw dfpepenses
     1141 ddsqlsedsl aekryqspkn rlggnrptnn rgqprtrtra svrgftaasd sdllaqthrs
     1201 fsldslidae eelgedqqee pfpgsadeip tetfwhleds slpvmdqeai crlgpinyrt
     1261 aarldavlpm sssfyldpqf qphcelqphc elqphcelqp hceqaesqve psyseqadsl
     1321 qgmqlsresp lmsmdswfsc dskinpsspp givgslcpsp dmqefhsckg erpgywpnte
     1381 elkpsdaetv lpyssklhqg stellcsard ehtasaadts rlslwgiqrl iqpgadgtfq
     1441 grcipdmtqq gsseashnss vsnvlaasat tlthvgsthe rdwsalqqky llelscpvle
     1501 aigapkpayp yleedsgsla qasskggdtl lpvgprvssn lnlnnfpvhl srirrlraek
     1561 eqdslnakle gvsdffstse keasydetys adleslsasr stnaqvfate naipdsmtea
     1621 cevkqnnlee clqscrkpgl mtssdedffq knachsnvtt atkadhwsqg waplrknsav
     1681 qpgqlspdsh ypleeektdc qesskeavrr hinvsfalps gpelylhsap wnplssslqp
     1741 plletfyvtk srdaltetal eipacrevrv pspppreawg fghnhqalqg aylknnlpvl
     1801 lqnqnskias sqqvtaeipv dlntrevire sgkcpgnite eshdsvyssv tqnrhflpst
     1861 stkvcefenq vvilnkkhsf paleggevta qsccgassds tesgksllfr eseareeeel
     1921 dqntvlrqti nvslekdmpg esavslksrs vdrrvsspvm vaqgggptpk wegknetgll
     1981 ekglrpkdss eefklpgtkp ayerfqlvac pqernpseck sqemlnpnre psgkkqnkrv
     2041 nntdemarli rsvmqlengi leieskqnkq vhashtpgtd kelvfqdqke qektdhafrp
     2101 dssgnplpsk dqpssprqtd dtvfrdseag amevnsignh pqvqkitpnp frsregvres
     2161 epvrehthpa gsdrpardic dslgkhttcr eftntslhpq rmkalaralp lqprlerssk
     2221 nngqfvkasa slkgqpwglg sleeletvkg fqesqvaehv sssnqeepka qgkveempmq
     2281 rggslqeenk vtqkfpslsq lcrdtffrqe tvspllsrte fctaplhqdl sntlplnspr
     2341 wprrclhvpv algissldcv ldltmlkihn splvtgvehq dqstetrshs pegnvrgrss
     2401 eahtawcgsv rsmamgshsq sgvpesiplg tedrisasts pqdhgkdlri tllgfstsed
     2461 faseaevavq keirvsslnk vssqpekrvs fsleedsdqa skprqkaeke tedvgltsgv
     2521 slapvslprv pspeprllep sdhasmclai leeirqakaq rkqlhdfvar gtvlsycetl
     2581 lepecssrva grpqckqidq sssdqtrneg eapgfhvasl saeagqidll pderkvqats
     2641 lsadsfeslp ntetdrepwd pvqafshaap aqdrkrrtge lrqfagasep fichssssei
     2701 iekkkdatrt pssadplapd sprssapvee vrrvvskkvv aalpsqapyd dprvtlhels
     2761 qsvpqetaeg ippgsqdssp ehqeprtldt tygevsdnll vtaqgektah fesqsvtcdv
     2821 qnstsasgpk qdhvqcpeas tgfeegrasp kqdtilpgal trvaleaptq qcvqckesvg
     2881 sgltevcrag skhsrpiplp dqrpsanpgg igeeapcrhp realdgpvfs rnpegsrtls
     2941 psrgkesrtl pcrqpcssqp vathaysshs stllcfrdgd lgkepfkaap htihppcvvp
     3001 srayemdetg eisrgpdvhl thglepkdvn refrltesst cepstvaavl sraqgcrsps
     3061 apdvrtgsfs hsatdgsvgl igvpekkvae kqasteleaa sfpagmysep lrqfrdssvg
     3121 dqnaqvcqtn peppattqgp htldlsegsa esklvvepqh eclenttrcf lekpqfstel
     3181 rdhnrldsqa kfvarlkhtc spqedspwqe eeqhrdqasg ggegfaqgvn plpdedgldg
     3241 cqildagree vavakppvsk ilsqgfkdpa tvslrqnetp qpaaqrsghl ytgreqpapn
     3301 hrgslpvtti fsgpkhsrss ptpqfsvvgs srslqelnls veppsptded tqgpnrlwnp
     3361 hlrgyssgks vartslqaed snqkassrld dgttdhrhlk patppypmps tlshmptpdf
     3421 ttswmsgtle qaqqgkrekl gvqvrpenwc sqmdkgmlhf gssdispyal pwrpeepari
     3481 swkqymsgsa vdvscsqkpq gltlsnvarc ssmdngledq nspfhshlst yanicdlstt
     3541 hsstenaqgs neawevfrgs ssialgdphi ptspegvapt sghdrrpqfr gpsgeadclr
     3601 skpplakgsa agpvdeimll ypseagcpvg qtrtntfeqg tqtlgsrrhw sstdisfaqp
     3661 easavsafdl aswtsmhnls lhlsqllhst sellgslsqp dvarreqntk rdipdkapqa
     3721 lmmdgstqtt vdegsqtdlt lptlclqtse aepqganvil eglgsdtstv sqeegdvpgv
     3781 pqkreaeeta qkmaqllylq eestpykpqs psipsshlrf qkapvgqhlp svspsvsdaf
     3841 lppssqpees yclvvsspsp ssphspglfp stseypgdsr vqkklgptsa lfvdrasspi
     3901 ltlsastqep glspgsltls apsthpvegh qkldsspdpv daprtpmdny sqttdelggs
     3961 qrgrsslqrs ngrsflelhs phspqqspkl qfsflgqhpq qlqprttigv qsrllppplr
     4021 hrsqrlgnsf vpekvaspeh cplsgrepsq wqsrtengge ssaspgepqr tldrpsswgg
     4081 lqhlspcpvs eltdtaglrg salglpqacq peellcfscq mcmapehqhh slrdlpvhnk
     4141 fsnwcgvqkg spggldmtee elgasgdlss ekqeqsppqp pndhsqdsew skreqiplqv
     4201 gaqnlslsve lteaklhhgf geadallqvl qsgtgealaa depvtstwke lyarqkkaie
     4261 tlrreraerl gnfcrtrsls pqkqlsllpn kdlfiwdldl psrrreylqq lrkdvvettr
     4321 spesvsrsah tpsdielmlq dyqqaheeak veiarardql rerteqeklr ihqkiisqll
     4381 keedklhtla nssslctssn gslssgmtsg ynsspalsgq lqfpenmght nlpdsrdvwi
     4441 gdergghsav rknsayshra slgscccsps slsslgtcfs ssyqdlakhv vdtsmadvma
     4501 acsdnlhnlf scqatagwny qgeeqavqly ykvfsptrhg flgagvvsqp lsrvwaavsd
     4561 ptvwplyykp iqtarlhqrv tnsislvylv cnttlcalkq prdfccvcve akevpalvgh
     4621 lsvmaaqsvy dtsmprpsrk mvrgeilpsa wilqpitveg kevtrviyla qvelgapgfp
     4681 pqllssfikr qplviarlas flgr
//
LOCUS       XP_011520135            4694 aa            linear   PRI 05-AUG-2025
DEFINITION  stAR-related lipid transfer protein 9 isoform X3 [Homo sapiens].
ACCESSION   XP_011520135
VERSION     XP_011520135.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521833.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4694
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4694
                     /product="stAR-related lipid transfer protein 9 isoform
                     X3"
                     /calculated_mol_wt=515567
     Region          2..380
                     /region_name="Motor_domain"
                     /note="Myosin and Kinesin motor domain; cl22853"
                     /db_xref="CDD:473979"
     Site            order(11..12,103..110,202..203,242..247)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276814"
     Region          379..490
                     /region_name="Kinesin_assoc"
                     /note="Kinesin-associated; pfam16183"
                     /db_xref="CDD:465047"
     Region          460..578
                     /region_name="FHA_KIF16A_STARD9"
                     /note="forkhead associated (FHA) domain found in
                     StAR-related lipid transfer protein 9 (StARD9); cd22731"
                     /db_xref="CDD:438783"
     Region          <569..>775
                     /region_name="COG4913"
                     /note="Uncharacterized conserved protein, contains a
                     C-terminal ATPase domain [Function unknown]"
                     /db_xref="CDD:443941"
     Region          4485..4694
                     /region_name="START_STARD9-like"
                     /note="C-terminal START domain of mammalian STARD9, and
                     related domains; lipid binding; cd08874"
                     /db_xref="CDD:176883"
     Site            order(4511..4512,4519,4531,4533,4544,4548,4554,4557..4558,
                     4560..4561,4580,4582..4585,4589,4592,4594,4596,4616,4634,
                     4636..4639,4641,4656,4658,4660,4662,4664,4666,4669,
                     4671..4673,4677..4678,4682..4683,4686)
                     /site_type="other"
                     /note="putative lipid binding site [chemical binding]"
                     /db_xref="CDD:176883"
     CDS             1..4694
                     /gene="STARD9"
                     /gene_synonym="KIF16A"
                     /coded_by="XM_011521833.3:111..14195"
                     /db_xref="GeneID:57519"
                     /db_xref="HGNC:HGNC:19162"
                     /db_xref="MIM:614642"
ORIGIN      
        1 manvqvavrv rplskretke ggriivevdg kvakirnlkv dnrpdgfgds rekvmafgfd
       61 ycywsvnped pqyasqdvvf qdlgmevlsg vakgyniclf aygqtgsgkt ytmlgtpglf
      121 vrekdcaslp sscrikvsfl eiynervrdl lkqsgqkksy tlrvrehpem gpyvqglsqh
      181 vvtnykqviq lleegianri taathvheas srshaiftih ytqailennl psemaskinl
      241 vdlagserad psyckdriae ganinkslvt lgivistlaq nsqvfsscqs lnssvsnggd
      301 sgilsspsgt ssggapsrrq syipyrdsvl twllkdslgg nsktimvatv spahtsyset
      361 mstlryassa kniinkprvn edanlklire lreeierlka lllsfelrnf sslsdenlke
      421 lvlqnelkid qltkdwtqkw ndwqalmehy svdinrrrag vvidsslphl maleddvlst
      481 gvvlyhlkeg ttkigridsd qeqdivlqgq wierdhctit sacgvvvlrp argarctvng
      541 revtascrlt qgavitlgka qkfrfnhpae aavlrqrrqv geaaagrgsl ewldldgdla
      601 asrlglspll wkerraleeq cdedhqtprd getshraqiq qqqsyvedlr hqilaeeira
      661 akelefdqaw isqqikenqq cllreetwla slqqqqqedq vaekeleasv aldawlqtdp
      721 eiqpspfvqs qkrvvhlqll rrhtlraaer nvrrkkvsfq leriikkqrl leaqkrlekl
      781 ttlcwlqdds tqeppyqvls pdatvprppc rskltscssl spqrlcskhm pqlhsiflsw
      841 dpsttlpprp dpthqtsekt sseehlpqaa sypartgclr knglhssghg qpctaraala
      901 rkgasapdac ltmspnsvgi qememgvkqp hqmvsqglas lrksanklkp rhepkiftst
      961 tqtrgakgla dpshtqagwr kegnlgthka akgascnsly phgprqtagh gkavktfwte
     1021 ykppspsras krhqrvlatr vrnitkkssh lplgsplkrq qntrdpdtmv pltdfspvmd
     1081 hsrekdndls dtdsnyslds lscvyakali eplkpeerkw dfpepenses ddsqlsedsl
     1141 aekryqspkn rlggnrptnn rgqprtrtra svrgftaasd sdllaqthrs fsldslidae
     1201 eelgedqqee pfpgsadeip tetfwhleds slpvmdqeai crlgpinyrt aarldavlpm
     1261 sssfyldpqf qphcelqphc elqphcelqp hceqaesqve psyseqadsl qgmqlsresp
     1321 lmsmdswfsc dskinpsspp givgslcpsp dmqefhsckg erpgywpnte elkpsdaetv
     1381 lpyssklhqg stellcsard ehtasaadts rlslwgiqrl iqpgadgtfq grcipdmtqq
     1441 gsseashnss vsnvlaasat tlthvgsthe rdwsalqqky llelscpvle aigapkpayp
     1501 yleedsgsla qasskggdtl lpvgprvssn lnlnnfpvhl srirrlraek eqdslnakle
     1561 gvsdffstse keasydetys adleslsasr stnaqvfate naipdsmtea cevkqnnlee
     1621 clqscrkpgl mtssdedffq knachsnvtt atkadhwsqg waplrknsav qpgqlspdsh
     1681 ypleeektdc qesskeavrr hinvsfalps gpelylhsap wnplssslqp plletfyvtk
     1741 srdaltetal eipacrevrv pspppreawg fghnhqalqg aylknnlpvl lqnqnskias
     1801 sqqvtaeipv dlntrevire sgkcpgnite eshdsvyssv tqnrhflpst stkvcefenq
     1861 vvilnkkhsf paleggevta qsccgassds tesgksllfr eseareeeel dqntvlrqti
     1921 nvslekdmpg esavslksrs vdrrvsspvm vaqgggptpk wegknetgll ekglrpkdss
     1981 eefklpgtkp ayerfqlvac pqernpseck sqemlnpnre psgkkqnkrv nntdemarli
     2041 rsvmqlengi leieskqnkq vhashtpgtd kelvfqdqke qektdhafrp dssgnplpsk
     2101 dqpssprqtd dtvfrdseag amevnsignh pqvqkitpnp frsregvres epvrehthpa
     2161 gsdrpardic dslgkhttcr eftntslhpq rmkalaralp lqprlerssk nngqfvkasa
     2221 slkgqpwglg sleeletvkg fqesqvaehv sssnqeepka qgkveempmq rggslqeenk
     2281 vtqkfpslsq lcrdtffrqe tvspllsrte fctaplhqdl sntlplnspr wprrclhvpv
     2341 algissldcv ldltmlkihn splvtgvehq dqstetrshs pegnvrgrss eahtawcgsv
     2401 rsmamgshsq sgvpesiplg tedrisasts pqdhgkdlri tllgfstsed faseaevavq
     2461 keirvsslnk vssqpekrvs fsleedsdqa skprqkaeke tedvgltsgv slapvslprv
     2521 pspeprllep sdhasmclai leeirqakaq rkqlhdfvar gtvlsycetl lepecssrva
     2581 grpqckqidq sssdqtrneg eapgfhvasl saeagqidll pderkvqats lsadsfeslp
     2641 ntetdrepwd pvqafshaap aqdrkrrtge lrqfagasep fichssssei iekkkdatrt
     2701 pssadplapd sprssapvee vrrvvskkvv aalpsqapyd dprvtlhels qsvpqetaeg
     2761 ippgsqdssp ehqeprtldt tygevsdnll vtaqgektah fesqsvtcdv qnstsasgpk
     2821 qdhvqcpeas tgfeegrasp kqdtilpgal trvaleaptq qcvqckesvg sgltevcrag
     2881 skhsrpiplp dqrpsanpgg igeeapcrhp realdgpvfs rnpegsrtls psrgkesrtl
     2941 pcrqpcssqp vathaysshs stllcfrdgd lgkepfkaap htihppcvvp srayemdetg
     3001 eisrgpdvhl thglepkdvn refrltesst cepstvaavl sraqgcrsps apdvrtgsfs
     3061 hsatdgsvgl igvpekkvae kqasteleaa sfpagmysep lrqfrdssvg dqnaqvcqtn
     3121 peppattqgp htldlsegsa esklvvepqh eclenttrcf lekpqfstel rdhnrldsqa
     3181 kfvarlkhtc spqedspwqe eeqhrdqasg ggegfaqgvn plpdedgldg cqildagree
     3241 vavakppvsk ilsqgfkdpa tvslrqnetp qpaaqrsghl ytgreqpapn hrgslpvtti
     3301 fsgpkhsrss ptpqfsvvgs srslqelnls veppsptded tqgpnrlwnp hlrgyssgks
     3361 vartslqaed snqkassrld dgttdhrhlk patppypmps tlshmptpdf ttswmsgtle
     3421 qaqqgkrekl gvqvrpenwc sqmdkgmlhf gssdispyal pwrpeepari swkqymsgsa
     3481 vdvscsqkpq gltlsnvarc ssmdngledq nspfhshlst yanicdlstt hsstenaqgs
     3541 neawevfrgs ssialgdphi ptspegvapt sghdrrpqfr gpsgeadclr skpplakgsa
     3601 agpvdeimll ypseagcpvg qtrtntfeqg tqtlgsrrhw sstdisfaqp easavsafdl
     3661 aswtsmhnls lhlsqllhst sellgslsqp dvarreqntk rdipdkapqa lmmdgstqtt
     3721 vdegsqtdlt lptlclqtse aepqganvil eglgsdtstv sqeegdvpgv pqkreaeeta
     3781 qkmaqllylq eestpykpqs psipsshlrf qkapvgqhlp svspsvsdaf lppssqpees
     3841 yclvvsspsp ssphspglfp stseypgdsr vqkklgptsa lfvdrasspi ltlsastqep
     3901 glspgsltls apsthpvegh qkldsspdpv daprtpmdny sqttdelggs qrgrsslqrs
     3961 ngrsflelhs phspqqspkl qfsflgqhpq qlqprttigv qsrllppplr hrsqrlgnsf
     4021 vpekvaspeh cplsgrepsq wqsrtengge ssaspgepqr tldrpsswgg lqhlspcpvs
     4081 eltdtaglrg salglpqacq peellcfscq mcmapehqhh slrdlpvhnk fsnwcgvqkg
     4141 spggldmtee elgasgdlss ekqeqsppqp pndhsqdsew skreqiplqv gaqnlslsve
     4201 lteaklhhgf geadallqvl qsgtgealaa depvtstwke lyarqkkaie tlrreraerl
     4261 gnfcrtrsls pqkqlsllpn kdlfiwdldl psrrreylqq lrkdvvettr spesvsrsah
     4321 tpsdielmlq dyqqaheeak veiarardql rerteqeklr ihqkiisqll keedklhtla
     4381 nssslctssn gslssgmtsg ynsspalsgq lqfpenmght nlpdsrdvwi gdergghsav
     4441 rknsayshra slgscccsps slsslgtcfs ssyqdlakhv vdtsmadvma acsdnlhnlf
     4501 scqatagwny qgeeqavqly ykvfsptrhg flgagvvsqp lsrvwaavsd ptvwplyykp
     4561 iqtarlhqrv tnsislvylv cnttlcalkq prdfccvcve akevpalvgh lsvmaaqsvy
     4621 dtsmprpsrk mvrgeilpsa wilqpitveg kevtrviyla qvelgapgfp pqllssfikr
     4681 qplviarlas flgr
//
LOCUS       XP_011520136            4684 aa            linear   PRI 05-AUG-2025
DEFINITION  stAR-related lipid transfer protein 9 isoform X4 [Homo sapiens].
ACCESSION   XP_011520136
VERSION     XP_011520136.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521834.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4684
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4684
                     /product="stAR-related lipid transfer protein 9 isoform
                     X4"
                     /calculated_mol_wt=514236
     Region          2..391
                     /region_name="KISc_KIF1A_KIF1B"
                     /note="Kinesin motor domain, KIF1_like proteins; cd01365"
                     /db_xref="CDD:276816"
     Site            order(11,103,106,108..111,253)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276816"
     Site            order(337,340,343)
                     /site_type="other"
                     /note="microtubule interaction site [polypeptide binding]"
                     /db_xref="CDD:276816"
     Region          390..>422
                     /region_name="Kinesin_assoc"
                     /note="Kinesin-associated; pfam16183"
                     /db_xref="CDD:465047"
     Region          450..568
                     /region_name="FHA_KIF16A_STARD9"
                     /note="forkhead associated (FHA) domain found in
                     StAR-related lipid transfer protein 9 (StARD9); cd22731"
                     /db_xref="CDD:438783"
     Region          <559..>765
                     /region_name="COG4913"
                     /note="Uncharacterized conserved protein, contains a
                     C-terminal ATPase domain [Function unknown]"
                     /db_xref="CDD:443941"
     Region          4475..4684
                     /region_name="START_STARD9-like"
                     /note="C-terminal START domain of mammalian STARD9, and
                     related domains; lipid binding; cd08874"
                     /db_xref="CDD:176883"
     Site            order(4501..4502,4509,4521,4523,4534,4538,4544,4547..4548,
                     4550..4551,4570,4572..4575,4579,4582,4584,4586,4606,4624,
                     4626..4629,4631,4646,4648,4650,4652,4654,4656,4659,
                     4661..4663,4667..4668,4672..4673,4676)
                     /site_type="other"
                     /note="putative lipid binding site [chemical binding]"
                     /db_xref="CDD:176883"
     CDS             1..4684
                     /gene="STARD9"
                     /gene_synonym="KIF16A"
                     /coded_by="XM_011521834.4:111..14165"
                     /db_xref="GeneID:57519"
                     /db_xref="HGNC:HGNC:19162"
                     /db_xref="MIM:614642"
ORIGIN      
        1 manvqvavrv rplskretke ggriivevdg kvakirnlkv dnrpdgfgds rekvmafgfd
       61 ycywsvnped pqyasqdvvf qdlgmevlsg vakgyniclf aygqtgsgkt ytmlgtpasv
      121 gltpricegl fvrekdcasl psscrikvsf leiynervrd llkqsgqkks ytlrvrehpe
      181 mgpyvqglsq hvvtnykqvi qlleegianr itaathvhea ssrshaifti hytqailenn
      241 lpsemaskin lvdlagsera dpsyckdria eganinkslv tlgivistla qnsqvfsscq
      301 slnssvsngg dsgilsspsg tssggapsrr qsyipyrdsv ltwllkdslg gnsktimvat
      361 vspahtsyse tmstlryass akniinkprv nedanlklir elreeierlk alllsfelid
      421 qltkdwtqkw ndwqalmehy svdinrrrag vvidsslphl maleddvlst gvvlyhlkeg
      481 ttkigridsd qeqdivlqgq wierdhctit sacgvvvlrp argarctvng revtascrlt
      541 qgavitlgka qkfrfnhpae aavlrqrrqv geaaagrgsl ewldldgdla asrlglspll
      601 wkerraleeq cdedhqtprd getshraqiq qqqsyvedlr hqilaeeira akelefdqaw
      661 isqqikenqq cllreetwla slqqqqqedq vaekeleasv aldawlqtdp eiqpspfvqs
      721 qkrvvhlqll rrhtlraaer nvrrkkvsfq leriikkqrl leaqkrlekl ttlcwlqdds
      781 tqeppyqvls pdatvprppc rskltscssl spqrlcskhm pqlhsiflsw dpsttlpprp
      841 dpthqtsekt sseehlpqaa sypartgclr knglhssghg qpctaraala rkgasapdac
      901 ltmspnsvgi qememgvkqp hqmvsqglas lrksanklkp rhepkiftst tqtrgakgla
      961 dpshtqagwr kegnlgthka akgascnsly phgprqtagh gkavktfwte ykppspsras
     1021 krhqrvlatr vrnitkkssh lplgsplkrq qntrdpdtmv pltdfspvmd hsrekdndls
     1081 dtdsnyslds lscvyakali eplkpeerkw dfpepenses ddsqlsedsl aekryqspkn
     1141 rlggnrptnn rgqprtrtra svrgftaasd sdllaqthrs fsldslidae eelgedqqee
     1201 pfpgsadeip tetfwhleds slpvmdqeai crlgpinyrt aarldavlpm sssfyldpqf
     1261 qphcelqphc elqphcelqp hceqaesqve psyseqadsl qgmqlsresp lmsmdswfsc
     1321 dskinpsspp givgslcpsp dmqefhsckg erpgywpnte elkpsdaetv lpyssklhqg
     1381 stellcsard ehtasaadts rlslwgiqrl iqpgadgtfq grcipdmtqq gsseashnss
     1441 vsnvlaasat tlthvgsthe rdwsalqqky llelscpvle aigapkpayp yleedsgsla
     1501 qasskggdtl lpvgprvssn lnlnnfpvhl srirrlraek eqdslnakle gvsdffstse
     1561 keasydetys adleslsasr stnaqvfate naipdsmtea cevkqnnlee clqscrkpgl
     1621 mtssdedffq knachsnvtt atkadhwsqg waplrknsav qpgqlspdsh ypleeektdc
     1681 qesskeavrr hinvsfalps gpelylhsap wnplssslqp plletfyvtk srdaltetal
     1741 eipacrevrv pspppreawg fghnhqalqg aylknnlpvl lqnqnskias sqqvtaeipv
     1801 dlntrevire sgkcpgnite eshdsvyssv tqnrhflpst stkvcefenq vvilnkkhsf
     1861 paleggevta qsccgassds tesgksllfr eseareeeel dqntvlrqti nvslekdmpg
     1921 esavslksrs vdrrvsspvm vaqgggptpk wegknetgll ekglrpkdss eefklpgtkp
     1981 ayerfqlvac pqernpseck sqemlnpnre psgkkqnkrv nntdemarli rsvmqlengi
     2041 leieskqnkq vhashtpgtd kelvfqdqke qektdhafrp dssgnplpsk dqpssprqtd
     2101 dtvfrdseag amevnsignh pqvqkitpnp frsregvres epvrehthpa gsdrpardic
     2161 dslgkhttcr eftntslhpq rmkalaralp lqprlerssk nngqfvkasa slkgqpwglg
     2221 sleeletvkg fqesqvaehv sssnqeepka qgkveempmq rggslqeenk vtqkfpslsq
     2281 lcrdtffrqe tvspllsrte fctaplhqdl sntlplnspr wprrclhvpv algissldcv
     2341 ldltmlkihn splvtgvehq dqstetrshs pegnvrgrss eahtawcgsv rsmamgshsq
     2401 sgvpesiplg tedrisasts pqdhgkdlri tllgfstsed faseaevavq keirvsslnk
     2461 vssqpekrvs fsleedsdqa skprqkaeke tedvgltsgv slapvslprv pspeprllep
     2521 sdhasmclai leeirqakaq rkqlhdfvar gtvlsycetl lepecssrva grpqckqidq
     2581 sssdqtrneg eapgfhvasl saeagqidll pderkvqats lsadsfeslp ntetdrepwd
     2641 pvqafshaap aqdrkrrtge lrqfagasep fichssssei iekkkdatrt pssadplapd
     2701 sprssapvee vrrvvskkvv aalpsqapyd dprvtlhels qsvpqetaeg ippgsqdssp
     2761 ehqeprtldt tygevsdnll vtaqgektah fesqsvtcdv qnstsasgpk qdhvqcpeas
     2821 tgfeegrasp kqdtilpgal trvaleaptq qcvqckesvg sgltevcrag skhsrpiplp
     2881 dqrpsanpgg igeeapcrhp realdgpvfs rnpegsrtls psrgkesrtl pcrqpcssqp
     2941 vathaysshs stllcfrdgd lgkepfkaap htihppcvvp srayemdetg eisrgpdvhl
     3001 thglepkdvn refrltesst cepstvaavl sraqgcrsps apdvrtgsfs hsatdgsvgl
     3061 igvpekkvae kqasteleaa sfpagmysep lrqfrdssvg dqnaqvcqtn peppattqgp
     3121 htldlsegsa esklvvepqh eclenttrcf lekpqfstel rdhnrldsqa kfvarlkhtc
     3181 spqedspwqe eeqhrdqasg ggegfaqgvn plpdedgldg cqildagree vavakppvsk
     3241 ilsqgfkdpa tvslrqnetp qpaaqrsghl ytgreqpapn hrgslpvtti fsgpkhsrss
     3301 ptpqfsvvgs srslqelnls veppsptded tqgpnrlwnp hlrgyssgks vartslqaed
     3361 snqkassrld dgttdhrhlk patppypmps tlshmptpdf ttswmsgtle qaqqgkrekl
     3421 gvqvrpenwc sqmdkgmlhf gssdispyal pwrpeepari swkqymsgsa vdvscsqkpq
     3481 gltlsnvarc ssmdngledq nspfhshlst yanicdlstt hsstenaqgs neawevfrgs
     3541 ssialgdphi ptspegvapt sghdrrpqfr gpsgeadclr skpplakgsa agpvdeimll
     3601 ypseagcpvg qtrtntfeqg tqtlgsrrhw sstdisfaqp easavsafdl aswtsmhnls
     3661 lhlsqllhst sellgslsqp dvarreqntk rdipdkapqa lmmdgstqtt vdegsqtdlt
     3721 lptlclqtse aepqganvil eglgsdtstv sqeegdvpgv pqkreaeeta qkmaqllylq
     3781 eestpykpqs psipsshlrf qkapvgqhlp svspsvsdaf lppssqpees yclvvsspsp
     3841 ssphspglfp stseypgdsr vqkklgptsa lfvdrasspi ltlsastqep glspgsltls
     3901 apsthpvegh qkldsspdpv daprtpmdny sqttdelggs qrgrsslqrs ngrsflelhs
     3961 phspqqspkl qfsflgqhpq qlqprttigv qsrllppplr hrsqrlgnsf vpekvaspeh
     4021 cplsgrepsq wqsrtengge ssaspgepqr tldrpsswgg lqhlspcpvs eltdtaglrg
     4081 salglpqacq peellcfscq mcmapehqhh slrdlpvhnk fsnwcgvqkg spggldmtee
     4141 elgasgdlss ekqeqsppqp pndhsqdsew skreqiplqv gaqnlslsve lteaklhhgf
     4201 geadallqvl qsgtgealaa depvtstwke lyarqkkaie tlrreraerl gnfcrtrsls
     4261 pqkqlsllpn kdlfiwdldl psrrreylqq lrkdvvettr spesvsrsah tpsdielmlq
     4321 dyqqaheeak veiarardql rerteqeklr ihqkiisqll keedklhtla nssslctssn
     4381 gslssgmtsg ynsspalsgq lqfpenmght nlpdsrdvwi gdergghsav rknsayshra
     4441 slgscccsps slsslgtcfs ssyqdlakhv vdtsmadvma acsdnlhnlf scqatagwny
     4501 qgeeqavqly ykvfsptrhg flgagvvsqp lsrvwaavsd ptvwplyykp iqtarlhqrv
     4561 tnsislvylv cnttlcalkq prdfccvcve akevpalvgh lsvmaaqsvy dtsmprpsrk
     4621 mvrgeilpsa wilqpitveg kevtrviyla qvelgapgfp pqllssfikr qplviarlas
     4681 flgr
//
LOCUS       XP_016877928            4679 aa            linear   PRI 05-AUG-2025
DEFINITION  stAR-related lipid transfer protein 9 isoform X5 [Homo sapiens].
ACCESSION   XP_016877928
VERSION     XP_016877928.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022439.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4679
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4679
                     /product="stAR-related lipid transfer protein 9 isoform
                     X5"
                     /calculated_mol_wt=513587
     Region          2..391
                     /region_name="KISc_KIF1A_KIF1B"
                     /note="Kinesin motor domain, KIF1_like proteins; cd01365"
                     /db_xref="CDD:276816"
     Site            order(11,103,106,108..111,253)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276816"
     Site            order(337,340,343)
                     /site_type="other"
                     /note="microtubule interaction site [polypeptide binding]"
                     /db_xref="CDD:276816"
     Region          445..563
                     /region_name="FHA_KIF16A_STARD9"
                     /note="forkhead associated (FHA) domain found in
                     StAR-related lipid transfer protein 9 (StARD9); cd22731"
                     /db_xref="CDD:438783"
     Region          <554..>760
                     /region_name="COG4913"
                     /note="Uncharacterized conserved protein, contains a
                     C-terminal ATPase domain [Function unknown]"
                     /db_xref="CDD:443941"
     Region          4470..4679
                     /region_name="START_STARD9-like"
                     /note="C-terminal START domain of mammalian STARD9, and
                     related domains; lipid binding; cd08874"
                     /db_xref="CDD:176883"
     Site            order(4496..4497,4504,4516,4518,4529,4533,4539,4542..4543,
                     4545..4546,4565,4567..4570,4574,4577,4579,4581,4601,4619,
                     4621..4624,4626,4641,4643,4645,4647,4649,4651,4654,
                     4656..4658,4662..4663,4667..4668,4671)
                     /site_type="other"
                     /note="putative lipid binding site [chemical binding]"
                     /db_xref="CDD:176883"
     CDS             1..4679
                     /gene="STARD9"
                     /gene_synonym="KIF16A"
                     /coded_by="XM_017022439.3:111..14150"
                     /db_xref="GeneID:57519"
                     /db_xref="HGNC:HGNC:19162"
                     /db_xref="MIM:614642"
ORIGIN      
        1 manvqvavrv rplskretke ggriivevdg kvakirnlkv dnrpdgfgds rekvmafgfd
       61 ycywsvnped pqyasqdvvf qdlgmevlsg vakgyniclf aygqtgsgkt ytmlgtpasv
      121 gltpricegl fvrekdcasl psscrikvsf leiynervrd llkqsgqkks ytlrvrehpe
      181 mgpyvqglsq hvvtnykqvi qlleegianr itaathvhea ssrshaifti hytqailenn
      241 lpsemaskin lvdlagsera dpsyckdria eganinkslv tlgivistla qnsqvfsscq
      301 slnssvsngg dsgilsspsg tssggapsrr qsyipyrdsv ltwllkdslg gnsktimvat
      361 vspahtsyse tmstlryass akniinkprv nernfsslsd enlkelvlqn elkidqltkd
      421 wtqkwndwqa lmehysvdin rrragvvids slphlmaled dvlstgvvly hlkegttkig
      481 ridsdqeqdi vlqgqwierd hctitsacgv vvlrpargar ctvngrevta scrltqgavi
      541 tlgkaqkfrf nhpaeaavlr qrrqvgeaaa grgslewldl dgdlaasrlg lspllwkerr
      601 aleeqcdedh qtprdgetsh raqiqqqqsy vedlrhqila eeiraakele fdqawisqqi
      661 kenqqcllre etwlaslqqq qqedqvaeke leasvaldaw lqtdpeiqps pfvqsqkrvv
      721 hlqllrrhtl raaernvrrk kvsfqlerii kkqrlleaqk rleklttlcw lqddstqepp
      781 yqvlspdatv prppcrsklt scsslspqrl cskhmpqlhs iflswdpstt lpprpdpthq
      841 tsektsseeh lpqaasypar tgclrknglh ssghgqpcta raalarkgas apdacltmsp
      901 nsvgiqemem gvkqphqmvs qglaslrksa nklkprhepk iftsttqtrg akgladpsht
      961 qagwrkegnl gthkaakgas cnslyphgpr qtaghgkavk tfwteykpps psraskrhqr
     1021 vlatrvrnit kksshlplgs plkrqqntrd pdtmvpltdf spvmdhsrek dndlsdtdsn
     1081 ysldslscvy akalieplkp eerkwdfpep ensesddsql sedslaekry qspknrlggn
     1141 rptnnrgqpr trtrasvrgf taasdsdlla qthrsfslds lidaeeelge dqqeepfpgs
     1201 adeiptetfw hledsslpvm dqeaicrlgp inyrtaarld avlpmsssfy ldpqfqphce
     1261 lqphcelqph celqphceqa esqvepsyse qadslqgmql sresplmsmd swfscdskin
     1321 pssppgivgs lcpspdmqef hsckgerpgy wpnteelkps daetvlpyss klhqgstell
     1381 csardehtas aadtsrlslw giqrliqpga dgtfqgrcip dmtqqgssea shnssvsnvl
     1441 aasattlthv gstherdwsa lqqkyllels cpvleaigap kpaypyleed sgslaqassk
     1501 ggdtllpvgp rvssnlnlnn fpvhlsrirr lraekeqdsl naklegvsdf fstsekeasy
     1561 detysadles lsasrstnaq vfatenaipd smteacevkq nnleeclqsc rkpglmtssd
     1621 edffqknach snvttatkad hwsqgwaplr knsavqpgql spdshyplee ektdcqessk
     1681 eavrrhinvs falpsgpely lhsapwnpls sslqppllet fyvtksrdal tetaleipac
     1741 revrvpsppp reawgfghnh qalqgaylkn nlpvllqnqn skiassqqvt aeipvdlntr
     1801 eviresgkcp gniteeshds vyssvtqnrh flpststkvc efenqvviln kkhsfpaleg
     1861 gevtaqsccg assdstesgk sllfresear eeeeldqntv lrqtinvsle kdmpgesavs
     1921 lksrsvdrrv sspvmvaqgg gptpkwegkn etgllekglr pkdsseefkl pgtkpayerf
     1981 qlvacpqern psecksqeml npnrepsgkk qnkrvnntde marlirsvmq lengileies
     2041 kqnkqvhash tpgtdkelvf qdqkeqektd hafrpdssgn plpskdqpss prqtddtvfr
     2101 dseagamevn signhpqvqk itpnpfrsre gvresepvre hthpagsdrp ardicdslgk
     2161 httcreftnt slhpqrmkal aralplqprl erssknngqf vkasaslkgq pwglgsleel
     2221 etvkgfqesq vaehvsssnq eepkaqgkve empmqrggsl qeenkvtqkf pslsqlcrdt
     2281 ffrqetvspl lsrtefctap lhqdlsntlp lnsprwprrc lhvpvalgis sldcvldltm
     2341 lkihnsplvt gvehqdqste trshspegnv rgrsseahta wcgsvrsmam gshsqsgvpe
     2401 siplgtedri sastspqdhg kdlritllgf stsedfasea evavqkeirv sslnkvssqp
     2461 ekrvsfslee dsdqaskprq kaeketedvg ltsgvslapv slprvpspep rllepsdhas
     2521 mclaileeir qakaqrkqlh dfvargtvls ycetllepec ssrvagrpqc kqidqsssdq
     2581 trnegeapgf hvaslsaeag qidllpderk vqatslsads feslpntetd repwdpvqaf
     2641 shaapaqdrk rrtgelrqfa gasepfichs ssseiiekkk datrtpssad plapdsprss
     2701 apveevrrvv skkvvaalps qapyddprvt lhelsqsvpq etaegippgs qdsspehqep
     2761 rtldttygev sdnllvtaqg ektahfesqs vtcdvqnsts asgpkqdhvq cpeastgfee
     2821 graspkqdti lpgaltrval eaptqqcvqc kesvgsglte vcragskhsr piplpdqrps
     2881 anpggigeea pcrhpreald gpvfsrnpeg srtlspsrgk esrtlpcrqp cssqpvatha
     2941 ysshsstllc frdgdlgkep fkaaphtihp pcvvpsraye mdetgeisrg pdvhlthgle
     3001 pkdvnrefrl tesstcepst vaavlsraqg crspsapdvr tgsfshsatd gsvgligvpe
     3061 kkvaekqast eleaasfpag myseplrqfr dssvgdqnaq vcqtnpeppa ttqgphtldl
     3121 segsaesklv vepqheclen ttrcflekpq fstelrdhnr ldsqakfvar lkhtcspqed
     3181 spwqeeeqhr dqasgggegf aqgvnplpde dgldgcqild agreevavak ppvskilsqg
     3241 fkdpatvslr qnetpqpaaq rsghlytgre qpapnhrgsl pvttifsgpk hsrssptpqf
     3301 svvgssrslq elnlsvepps ptdedtqgpn rlwnphlrgy ssgksvarts lqaedsnqka
     3361 ssrlddgttd hrhlkpatpp ypmpstlshm ptpdfttswm sgtleqaqqg kreklgvqvr
     3421 penwcsqmdk gmlhfgssdi spyalpwrpe epariswkqy msgsavdvsc sqkpqgltls
     3481 nvarcssmdn gledqnspfh shlstyanic dlstthsste naqgsneawe vfrgsssial
     3541 gdphiptspe gvaptsghdr rpqfrgpsge adclrskppl akgsaagpvd eimllypsea
     3601 gcpvgqtrtn tfeqgtqtlg srrhwsstdi sfaqpeasav safdlaswts mhnlslhlsq
     3661 llhstsellg slsqpdvarr eqntkrdipd kapqalmmdg stqttvdegs qtdltlptlc
     3721 lqtseaepqg anvileglgs dtstvsqeeg dvpgvpqkre aeetaqkmaq llylqeestp
     3781 ykpqspsips shlrfqkapv gqhlpsvsps vsdaflppss qpeesyclvv sspspssphs
     3841 pglfpstsey pgdsrvqkkl gptsalfvdr asspiltlsa stqepglspg sltlsapsth
     3901 pveghqklds spdpvdaprt pmdnysqttd elggsqrgrs slqrsngrsf lelhsphspq
     3961 qspklqfsfl gqhpqqlqpr ttigvqsrll ppplrhrsqr lgnsfvpekv aspehcplsg
     4021 repsqwqsrt enggessasp gepqrtldrp sswgglqhls pcpvseltdt aglrgsalgl
     4081 pqacqpeell cfscqmcmap ehqhhslrdl pvhnkfsnwc gvqkgspggl dmteeelgas
     4141 gdlssekqeq sppqppndhs qdsewskreq iplqvgaqnl slsvelteak lhhgfgeada
     4201 llqvlqsgtg ealaadepvt stwkelyarq kkaietlrre raerlgnfcr trslspqkql
     4261 sllpnkdlfi wdldlpsrrr eylqqlrkdv vettrspesv srsahtpsdi elmlqdyqqa
     4321 heeakveiar ardqlrerte qeklrihqki isqllkeedk lhtlansssl ctssngslss
     4381 gmtsgynssp alsgqlqfpe nmghtnlpds rdvwigderg ghsavrknsa yshraslgsc
     4441 ccspsslssl gtcfsssyqd lakhvvdtsm advmaacsdn lhnlfscqat agwnyqgeeq
     4501 avqlyykvfs ptrhgflgag vvsqplsrvw aavsdptvwp lyykpiqtar lhqrvtnsis
     4561 lvylvcnttl calkqprdfc cvcveakevp alvghlsvma aqsvydtsmp rpsrkmvrge
     4621 ilpsawilqp itvegkevtr viylaqvelg apgfppqlls sfikrqplvi arlasflgr
//
LOCUS       XP_047288857            4668 aa            linear   PRI 05-AUG-2025
DEFINITION  stAR-related lipid transfer protein 9 isoform X6 [Homo sapiens].
ACCESSION   XP_047288857
VERSION     XP_047288857.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432901.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4668
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4668
                     /product="stAR-related lipid transfer protein 9 isoform
                     X6"
                     /calculated_mol_wt=512459
     Region          2..380
                     /region_name="Motor_domain"
                     /note="Myosin and Kinesin motor domain; cl22853"
                     /db_xref="CDD:473979"
     Site            order(11..12,103..110,202..203,242..247)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276814"
     Region          434..552
                     /region_name="FHA_KIF16A_STARD9"
                     /note="forkhead associated (FHA) domain found in
                     StAR-related lipid transfer protein 9 (StARD9); cd22731"
                     /db_xref="CDD:438783"
     Region          <543..>749
                     /region_name="COG4913"
                     /note="Uncharacterized conserved protein, contains a
                     C-terminal ATPase domain [Function unknown]"
                     /db_xref="CDD:443941"
     Region          4459..4668
                     /region_name="START_STARD9-like"
                     /note="C-terminal START domain of mammalian STARD9, and
                     related domains; lipid binding; cd08874"
                     /db_xref="CDD:176883"
     Site            order(4485..4486,4493,4505,4507,4518,4522,4528,4531..4532,
                     4534..4535,4554,4556..4559,4563,4566,4568,4570,4590,4608,
                     4610..4613,4615,4630,4632,4634,4636,4638,4640,4643,
                     4645..4647,4651..4652,4656..4657,4660)
                     /site_type="other"
                     /note="putative lipid binding site [chemical binding]"
                     /db_xref="CDD:176883"
     CDS             1..4668
                     /gene="STARD9"
                     /gene_synonym="KIF16A"
                     /coded_by="XM_047432901.1:111..14117"
                     /db_xref="GeneID:57519"
                     /db_xref="HGNC:HGNC:19162"
                     /db_xref="MIM:614642"
ORIGIN      
        1 manvqvavrv rplskretke ggriivevdg kvakirnlkv dnrpdgfgds rekvmafgfd
       61 ycywsvnped pqyasqdvvf qdlgmevlsg vakgyniclf aygqtgsgkt ytmlgtpglf
      121 vrekdcaslp sscrikvsfl eiynervrdl lkqsgqkksy tlrvrehpem gpyvqglsqh
      181 vvtnykqviq lleegianri taathvheas srshaiftih ytqailennl psemaskinl
      241 vdlagserad psyckdriae ganinkslvt lgivistlaq nsqvfsscqs lnssvsnggd
      301 sgilsspsgt ssggapsrrq syipyrdsvl twllkdslgg nsktimvatv spahtsyset
      361 mstlryassa kniinkprvn ernfsslsde nlkelvlqne lkidqltkdw tqkwndwqal
      421 mehysvdinr rragvvidss lphlmaledd vlstgvvlyh lkegttkigr idsdqeqdiv
      481 lqgqwierdh ctitsacgvv vlrpargarc tvngrevtas crltqgavit lgkaqkfrfn
      541 hpaeaavlrq rrqvgeaaag rgslewldld gdlaasrlgl spllwkerra leeqcdedhq
      601 tprdgetshr aqiqqqqsyv edlrhqilae eiraakelef dqawisqqik enqqcllree
      661 twlaslqqqq qedqvaekel easvaldawl qtdpeiqpsp fvqsqkrvvh lqllrrhtlr
      721 aaernvrrkk vsfqleriik kqrlleaqkr leklttlcwl qddstqeppy qvlspdatvp
      781 rppcrsklts csslspqrlc skhmpqlhsi flswdpsttl pprpdpthqt sektsseehl
      841 pqaasypart gclrknglhs sghgqpctar aalarkgasa pdacltmspn svgiqememg
      901 vkqphqmvsq glaslrksan klkprhepki ftsttqtrga kgladpshtq agwrkegnlg
      961 thkaakgasc nslyphgprq taghgkavkt fwteykppsp sraskrhqrv latrvrnitk
     1021 ksshlplgsp lkrqqntrdp dtmvpltdfs pvmdhsrekd ndlsdtdsny sldslscvya
     1081 kalieplkpe erkwdfpepe nsesddsqls edslaekryq spknrlggnr ptnnrgqprt
     1141 rtrasvrgft aasdsdllaq thrsfsldsl idaeeelged qqeepfpgsa deiptetfwh
     1201 ledsslpvmd qeaicrlgpi nyrtaarlda vlpmsssfyl dpqfqphcel qphcelqphc
     1261 elqphceqae sqvepsyseq adslqgmqls resplmsmds wfscdskinp ssppgivgsl
     1321 cpspdmqefh sckgerpgyw pnteelkpsd aetvlpyssk lhqgstellc sardehtasa
     1381 adtsrlslwg iqrliqpgad gtfqgrcipd mtqqgsseas hnssvsnvla asattlthvg
     1441 stherdwsal qqkyllelsc pvleaigapk paypyleeds gslaqasskg gdtllpvgpr
     1501 vssnlnlnnf pvhlsrirrl raekeqdsln aklegvsdff stsekeasyd etysadlesl
     1561 sasrstnaqv fatenaipds mteacevkqn nleeclqscr kpglmtssde dffqknachs
     1621 nvttatkadh wsqgwaplrk nsavqpgqls pdshypleee ktdcqesske avrrhinvsf
     1681 alpsgpelyl hsapwnplss slqpplletf yvtksrdalt etaleipacr evrvpspppr
     1741 eawgfghnhq alqgaylknn lpvllqnqns kiassqqvta eipvdlntre viresgkcpg
     1801 niteeshdsv yssvtqnrhf lpststkvce fenqvvilnk khsfpalegg evtaqsccga
     1861 ssdstesgks llfreseare eeeldqntvl rqtinvslek dmpgesavsl ksrsvdrrvs
     1921 spvmvaqggg ptpkwegkne tgllekglrp kdsseefklp gtkpayerfq lvacpqernp
     1981 secksqemln pnrepsgkkq nkrvnntdem arlirsvmql engileiesk qnkqvhasht
     2041 pgtdkelvfq dqkeqektdh afrpdssgnp lpskdqpssp rqtddtvfrd seagamevns
     2101 ignhpqvqki tpnpfrsreg vresepvreh thpagsdrpa rdicdslgkh ttcreftnts
     2161 lhpqrmkala ralplqprle rssknngqfv kasaslkgqp wglgsleele tvkgfqesqv
     2221 aehvsssnqe epkaqgkvee mpmqrggslq eenkvtqkfp slsqlcrdtf frqetvspll
     2281 srtefctapl hqdlsntlpl nsprwprrcl hvpvalgiss ldcvldltml kihnsplvtg
     2341 vehqdqstet rshspegnvr grsseahtaw cgsvrsmamg shsqsgvpes iplgtedris
     2401 astspqdhgk dlritllgfs tsedfaseae vavqkeirvs slnkvssqpe krvsfsleed
     2461 sdqaskprqk aeketedvgl tsgvslapvs lprvpspepr llepsdhasm claileeirq
     2521 akaqrkqlhd fvargtvlsy cetllepecs srvagrpqck qidqsssdqt rnegeapgfh
     2581 vaslsaeagq idllpderkv qatslsadsf eslpntetdr epwdpvqafs haapaqdrkr
     2641 rtgelrqfag asepfichss sseiiekkkd atrtpssadp lapdsprssa pveevrrvvs
     2701 kkvvaalpsq apyddprvtl helsqsvpqe taegippgsq dsspehqepr tldttygevs
     2761 dnllvtaqge ktahfesqsv tcdvqnstsa sgpkqdhvqc peastgfeeg raspkqdtil
     2821 pgaltrvale aptqqcvqck esvgsgltev cragskhsrp iplpdqrpsa npggigeeap
     2881 crhprealdg pvfsrnpegs rtlspsrgke srtlpcrqpc ssqpvathay sshsstllcf
     2941 rdgdlgkepf kaaphtihpp cvvpsrayem detgeisrgp dvhlthglep kdvnrefrlt
     3001 esstcepstv aavlsraqgc rspsapdvrt gsfshsatdg svgligvpek kvaekqaste
     3061 leaasfpagm yseplrqfrd ssvgdqnaqv cqtnpeppat tqgphtldls egsaesklvv
     3121 epqheclent trcflekpqf stelrdhnrl dsqakfvarl khtcspqeds pwqeeeqhrd
     3181 qasgggegfa qgvnplpded gldgcqilda greevavakp pvskilsqgf kdpatvslrq
     3241 netpqpaaqr sghlytgreq papnhrgslp vttifsgpkh srssptpqfs vvgssrslqe
     3301 lnlsveppsp tdedtqgpnr lwnphlrgys sgksvartsl qaedsnqkas srlddgttdh
     3361 rhlkpatppy pmpstlshmp tpdfttswms gtleqaqqgk reklgvqvrp enwcsqmdkg
     3421 mlhfgssdis pyalpwrpee pariswkqym sgsavdvscs qkpqgltlsn varcssmdng
     3481 ledqnspfhs hlstyanicd lstthssten aqgsneawev frgsssialg dphiptspeg
     3541 vaptsghdrr pqfrgpsgea dclrskppla kgsaagpvde imllypseag cpvgqtrtnt
     3601 feqgtqtlgs rrhwsstdis faqpeasavs afdlaswtsm hnlslhlsql lhstsellgs
     3661 lsqpdvarre qntkrdipdk apqalmmdgs tqttvdegsq tdltlptlcl qtseaepqga
     3721 nvileglgsd tstvsqeegd vpgvpqkrea eetaqkmaql lylqeestpy kpqspsipss
     3781 hlrfqkapvg qhlpsvspsv sdaflppssq peesyclvvs spspssphsp glfpstseyp
     3841 gdsrvqkklg ptsalfvdra sspiltlsas tqepglspgs ltlsapsthp veghqkldss
     3901 pdpvdaprtp mdnysqttde lggsqrgrss lqrsngrsfl elhsphspqq spklqfsflg
     3961 qhpqqlqprt tigvqsrllp pplrhrsqrl gnsfvpekva spehcplsgr epsqwqsrte
     4021 nggessaspg epqrtldrps swgglqhlsp cpvseltdta glrgsalglp qacqpeellc
     4081 fscqmcmape hqhhslrdlp vhnkfsnwcg vqkgspggld mteeelgasg dlssekqeqs
     4141 ppqppndhsq dsewskreqi plqvgaqnls lsvelteakl hhgfgeadal lqvlqsgtge
     4201 alaadepvts twkelyarqk kaietlrrer aerlgnfcrt rslspqkqls llpnkdlfiw
     4261 dldlpsrrre ylqqlrkdvv ettrspesvs rsahtpsdie lmlqdyqqah eeakveiara
     4321 rdqlrerteq eklrihqkii sqllkeedkl htlanssslc tssngslssg mtsgynsspa
     4381 lsgqlqfpen mghtnlpdsr dvwigdergg hsavrknsay shraslgscc cspsslsslg
     4441 tcfsssyqdl akhvvdtsma dvmaacsdnl hnlfscqata gwnyqgeeqa vqlyykvfsp
     4501 trhgflgagv vsqplsrvwa avsdptvwpl yykpiqtarl hqrvtnsisl vylvcnttlc
     4561 alkqprdfcc vcveakevpa lvghlsvmaa qsvydtsmpr psrkmvrgei lpsawilqpi
     4621 tvegkevtrv iylaqvelga pgfppqllss fikrqplvia rlasflgr
//
LOCUS       XP_011520137            4658 aa            linear   PRI 05-AUG-2025
DEFINITION  stAR-related lipid transfer protein 9 isoform X7 [Homo sapiens].
ACCESSION   XP_011520137
VERSION     XP_011520137.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521835.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4658
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4658
                     /product="stAR-related lipid transfer protein 9 isoform
                     X7"
                     /calculated_mol_wt=511128
     Region          2..391
                     /region_name="KISc_KIF1A_KIF1B"
                     /note="Kinesin motor domain, KIF1_like proteins; cd01365"
                     /db_xref="CDD:276816"
     Site            order(11,103,106,108..111,253)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276816"
     Site            order(337,340,343)
                     /site_type="other"
                     /note="microtubule interaction site [polypeptide binding]"
                     /db_xref="CDD:276816"
     Region          424..542
                     /region_name="FHA_KIF16A_STARD9"
                     /note="forkhead associated (FHA) domain found in
                     StAR-related lipid transfer protein 9 (StARD9); cd22731"
                     /db_xref="CDD:438783"
     Region          <533..>739
                     /region_name="COG4913"
                     /note="Uncharacterized conserved protein, contains a
                     C-terminal ATPase domain [Function unknown]"
                     /db_xref="CDD:443941"
     Region          4449..4658
                     /region_name="START_STARD9-like"
                     /note="C-terminal START domain of mammalian STARD9, and
                     related domains; lipid binding; cd08874"
                     /db_xref="CDD:176883"
     Site            order(4475..4476,4483,4495,4497,4508,4512,4518,4521..4522,
                     4524..4525,4544,4546..4549,4553,4556,4558,4560,4580,4598,
                     4600..4603,4605,4620,4622,4624,4626,4628,4630,4633,
                     4635..4637,4641..4642,4646..4647,4650)
                     /site_type="other"
                     /note="putative lipid binding site [chemical binding]"
                     /db_xref="CDD:176883"
     CDS             1..4658
                     /gene="STARD9"
                     /gene_synonym="KIF16A"
                     /coded_by="XM_011521835.4:111..14087"
                     /db_xref="GeneID:57519"
                     /db_xref="HGNC:HGNC:19162"
                     /db_xref="MIM:614642"
ORIGIN      
        1 manvqvavrv rplskretke ggriivevdg kvakirnlkv dnrpdgfgds rekvmafgfd
       61 ycywsvnped pqyasqdvvf qdlgmevlsg vakgyniclf aygqtgsgkt ytmlgtpasv
      121 gltpricegl fvrekdcasl psscrikvsf leiynervrd llkqsgqkks ytlrvrehpe
      181 mgpyvqglsq hvvtnykqvi qlleegianr itaathvhea ssrshaifti hytqailenn
      241 lpsemaskin lvdlagsera dpsyckdria eganinkslv tlgivistla qnsqvfsscq
      301 slnssvsngg dsgilsspsg tssggapsrr qsyipyrdsv ltwllkdslg gnsktimvat
      361 vspahtsyse tmstlryass akniinkprv neidqltkdw tqkwndwqal mehysvdinr
      421 rragvvidss lphlmaledd vlstgvvlyh lkegttkigr idsdqeqdiv lqgqwierdh
      481 ctitsacgvv vlrpargarc tvngrevtas crltqgavit lgkaqkfrfn hpaeaavlrq
      541 rrqvgeaaag rgslewldld gdlaasrlgl spllwkerra leeqcdedhq tprdgetshr
      601 aqiqqqqsyv edlrhqilae eiraakelef dqawisqqik enqqcllree twlaslqqqq
      661 qedqvaekel easvaldawl qtdpeiqpsp fvqsqkrvvh lqllrrhtlr aaernvrrkk
      721 vsfqleriik kqrlleaqkr leklttlcwl qddstqeppy qvlspdatvp rppcrsklts
      781 csslspqrlc skhmpqlhsi flswdpsttl pprpdpthqt sektsseehl pqaasypart
      841 gclrknglhs sghgqpctar aalarkgasa pdacltmspn svgiqememg vkqphqmvsq
      901 glaslrksan klkprhepki ftsttqtrga kgladpshtq agwrkegnlg thkaakgasc
      961 nslyphgprq taghgkavkt fwteykppsp sraskrhqrv latrvrnitk ksshlplgsp
     1021 lkrqqntrdp dtmvpltdfs pvmdhsrekd ndlsdtdsny sldslscvya kalieplkpe
     1081 erkwdfpepe nsesddsqls edslaekryq spknrlggnr ptnnrgqprt rtrasvrgft
     1141 aasdsdllaq thrsfsldsl idaeeelged qqeepfpgsa deiptetfwh ledsslpvmd
     1201 qeaicrlgpi nyrtaarlda vlpmsssfyl dpqfqphcel qphcelqphc elqphceqae
     1261 sqvepsyseq adslqgmqls resplmsmds wfscdskinp ssppgivgsl cpspdmqefh
     1321 sckgerpgyw pnteelkpsd aetvlpyssk lhqgstellc sardehtasa adtsrlslwg
     1381 iqrliqpgad gtfqgrcipd mtqqgsseas hnssvsnvla asattlthvg stherdwsal
     1441 qqkyllelsc pvleaigapk paypyleeds gslaqasskg gdtllpvgpr vssnlnlnnf
     1501 pvhlsrirrl raekeqdsln aklegvsdff stsekeasyd etysadlesl sasrstnaqv
     1561 fatenaipds mteacevkqn nleeclqscr kpglmtssde dffqknachs nvttatkadh
     1621 wsqgwaplrk nsavqpgqls pdshypleee ktdcqesske avrrhinvsf alpsgpelyl
     1681 hsapwnplss slqpplletf yvtksrdalt etaleipacr evrvpspppr eawgfghnhq
     1741 alqgaylknn lpvllqnqns kiassqqvta eipvdlntre viresgkcpg niteeshdsv
     1801 yssvtqnrhf lpststkvce fenqvvilnk khsfpalegg evtaqsccga ssdstesgks
     1861 llfreseare eeeldqntvl rqtinvslek dmpgesavsl ksrsvdrrvs spvmvaqggg
     1921 ptpkwegkne tgllekglrp kdsseefklp gtkpayerfq lvacpqernp secksqemln
     1981 pnrepsgkkq nkrvnntdem arlirsvmql engileiesk qnkqvhasht pgtdkelvfq
     2041 dqkeqektdh afrpdssgnp lpskdqpssp rqtddtvfrd seagamevns ignhpqvqki
     2101 tpnpfrsreg vresepvreh thpagsdrpa rdicdslgkh ttcreftnts lhpqrmkala
     2161 ralplqprle rssknngqfv kasaslkgqp wglgsleele tvkgfqesqv aehvsssnqe
     2221 epkaqgkvee mpmqrggslq eenkvtqkfp slsqlcrdtf frqetvspll srtefctapl
     2281 hqdlsntlpl nsprwprrcl hvpvalgiss ldcvldltml kihnsplvtg vehqdqstet
     2341 rshspegnvr grsseahtaw cgsvrsmamg shsqsgvpes iplgtedris astspqdhgk
     2401 dlritllgfs tsedfaseae vavqkeirvs slnkvssqpe krvsfsleed sdqaskprqk
     2461 aeketedvgl tsgvslapvs lprvpspepr llepsdhasm claileeirq akaqrkqlhd
     2521 fvargtvlsy cetllepecs srvagrpqck qidqsssdqt rnegeapgfh vaslsaeagq
     2581 idllpderkv qatslsadsf eslpntetdr epwdpvqafs haapaqdrkr rtgelrqfag
     2641 asepfichss sseiiekkkd atrtpssadp lapdsprssa pveevrrvvs kkvvaalpsq
     2701 apyddprvtl helsqsvpqe taegippgsq dsspehqepr tldttygevs dnllvtaqge
     2761 ktahfesqsv tcdvqnstsa sgpkqdhvqc peastgfeeg raspkqdtil pgaltrvale
     2821 aptqqcvqck esvgsgltev cragskhsrp iplpdqrpsa npggigeeap crhprealdg
     2881 pvfsrnpegs rtlspsrgke srtlpcrqpc ssqpvathay sshsstllcf rdgdlgkepf
     2941 kaaphtihpp cvvpsrayem detgeisrgp dvhlthglep kdvnrefrlt esstcepstv
     3001 aavlsraqgc rspsapdvrt gsfshsatdg svgligvpek kvaekqaste leaasfpagm
     3061 yseplrqfrd ssvgdqnaqv cqtnpeppat tqgphtldls egsaesklvv epqheclent
     3121 trcflekpqf stelrdhnrl dsqakfvarl khtcspqeds pwqeeeqhrd qasgggegfa
     3181 qgvnplpded gldgcqilda greevavakp pvskilsqgf kdpatvslrq netpqpaaqr
     3241 sghlytgreq papnhrgslp vttifsgpkh srssptpqfs vvgssrslqe lnlsveppsp
     3301 tdedtqgpnr lwnphlrgys sgksvartsl qaedsnqkas srlddgttdh rhlkpatppy
     3361 pmpstlshmp tpdfttswms gtleqaqqgk reklgvqvrp enwcsqmdkg mlhfgssdis
     3421 pyalpwrpee pariswkqym sgsavdvscs qkpqgltlsn varcssmdng ledqnspfhs
     3481 hlstyanicd lstthssten aqgsneawev frgsssialg dphiptspeg vaptsghdrr
     3541 pqfrgpsgea dclrskppla kgsaagpvde imllypseag cpvgqtrtnt feqgtqtlgs
     3601 rrhwsstdis faqpeasavs afdlaswtsm hnlslhlsql lhstsellgs lsqpdvarre
     3661 qntkrdipdk apqalmmdgs tqttvdegsq tdltlptlcl qtseaepqga nvileglgsd
     3721 tstvsqeegd vpgvpqkrea eetaqkmaql lylqeestpy kpqspsipss hlrfqkapvg
     3781 qhlpsvspsv sdaflppssq peesyclvvs spspssphsp glfpstseyp gdsrvqkklg
     3841 ptsalfvdra sspiltlsas tqepglspgs ltlsapsthp veghqkldss pdpvdaprtp
     3901 mdnysqttde lggsqrgrss lqrsngrsfl elhsphspqq spklqfsflg qhpqqlqprt
     3961 tigvqsrllp pplrhrsqrl gnsfvpekva spehcplsgr epsqwqsrte nggessaspg
     4021 epqrtldrps swgglqhlsp cpvseltdta glrgsalglp qacqpeellc fscqmcmape
     4081 hqhhslrdlp vhnkfsnwcg vqkgspggld mteeelgasg dlssekqeqs ppqppndhsq
     4141 dsewskreqi plqvgaqnls lsvelteakl hhgfgeadal lqvlqsgtge alaadepvts
     4201 twkelyarqk kaietlrrer aerlgnfcrt rslspqkqls llpnkdlfiw dldlpsrrre
     4261 ylqqlrkdvv ettrspesvs rsahtpsdie lmlqdyqqah eeakveiara rdqlrerteq
     4321 eklrihqkii sqllkeedkl htlanssslc tssngslssg mtsgynsspa lsgqlqfpen
     4381 mghtnlpdsr dvwigdergg hsavrknsay shraslgscc cspsslsslg tcfsssyqdl
     4441 akhvvdtsma dvmaacsdnl hnlfscqata gwnyqgeeqa vqlyykvfsp trhgflgagv
     4501 vsqplsrvwa avsdptvwpl yykpiqtarl hqrvtnsisl vylvcnttlc alkqprdfcc
     4561 vcveakevpa lvghlsvmaa qsvydtsmpr psrkmvrgei lpsawilqpi tvegkevtrv
     4621 iylaqvelga pgfppqllss fikrqplvia rlasflgr
//
LOCUS       XP_011520138            4651 aa            linear   PRI 05-AUG-2025
DEFINITION  stAR-related lipid transfer protein 9 isoform X8 [Homo sapiens].
ACCESSION   XP_011520138
VERSION     XP_011520138.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521836.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4651
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4651
                     /product="stAR-related lipid transfer protein 9 isoform
                     X8"
                     /calculated_mol_wt=510680
     Region          1..337
                     /region_name="Motor_domain"
                     /note="Myosin and Kinesin motor domain; cl22853"
                     /db_xref="CDD:473979"
     Site            order(49..56,159..160,199..204)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276814"
     Region          336..447
                     /region_name="Kinesin_assoc"
                     /note="Kinesin-associated; pfam16183"
                     /db_xref="CDD:465047"
     Region          417..535
                     /region_name="FHA_KIF16A_STARD9"
                     /note="forkhead associated (FHA) domain found in
                     StAR-related lipid transfer protein 9 (StARD9); cd22731"
                     /db_xref="CDD:438783"
     Region          <526..>732
                     /region_name="COG4913"
                     /note="Uncharacterized conserved protein, contains a
                     C-terminal ATPase domain [Function unknown]"
                     /db_xref="CDD:443941"
     Region          4442..4651
                     /region_name="START_STARD9-like"
                     /note="C-terminal START domain of mammalian STARD9, and
                     related domains; lipid binding; cd08874"
                     /db_xref="CDD:176883"
     Site            order(4468..4469,4476,4488,4490,4501,4505,4511,4514..4515,
                     4517..4518,4537,4539..4542,4546,4549,4551,4553,4573,4591,
                     4593..4596,4598,4613,4615,4617,4619,4621,4623,4626,
                     4628..4630,4634..4635,4639..4640,4643)
                     /site_type="other"
                     /note="putative lipid binding site [chemical binding]"
                     /db_xref="CDD:176883"
     CDS             1..4651
                     /gene="STARD9"
                     /gene_synonym="KIF16A"
                     /coded_by="XM_011521836.3:538..14493"
                     /db_xref="GeneID:57519"
                     /db_xref="HGNC:HGNC:19162"
                     /db_xref="MIM:614642"
ORIGIN      
        1 mafgfdycyw svnpedpqya sqdvvfqdlg mevlsgvakg yniclfaygq tgsgktytml
       61 gtpasvgltp riceglfvre kdcaslpssc rikvsfleiy nervrdllkq sgqkksytlr
      121 vrehpemgpy vqglsqhvvt nykqviqlle egianritaa thvheassrs haiftihytq
      181 ailennlpse maskinlvdl agseradpsy ckdriaegan inkslvtlgi vistlaqnsq
      241 vfsscqslns svsnggdsgi lsspsgtssg gapsrrqsyi pyrdsvltwl lkdslggnsk
      301 timvatvspa htsysetmst lryassakni inkprvneda nlklirelre eierlkalll
      361 sfelrnfssl sdenlkelvl qnelkidqlt kdwtqkwndw qalmehysvd inrrragvvi
      421 dsslphlmal eddvlstgvv lyhlkegttk igridsdqeq divlqgqwie rdhctitsac
      481 gvvvlrparg arctvngrev tascrltqga vitlgkaqkf rfnhpaeaav lrqrrqvgea
      541 aagrgslewl dldgdlaasr lglspllwke rraleeqcde dhqtprdget shraqiqqqq
      601 syvedlrhqi laeeiraake lefdqawisq qikenqqcll reetwlaslq qqqqedqvae
      661 keleasvald awlqtdpeiq pspfvqsqkr vvhlqllrrh tlraaernvr rkkvsfqler
      721 iikkqrllea qkrleklttl cwlqddstqe ppyqvlspda tvprppcrsk ltscsslspq
      781 rlcskhmpql hsiflswdps ttlpprpdpt hqtsektsse ehlpqaasyp artgclrkng
      841 lhssghgqpc taraalarkg asapdacltm spnsvgiqem emgvkqphqm vsqglaslrk
      901 sanklkprhe pkiftsttqt rgakgladps htqagwrkeg nlgthkaakg ascnslyphg
      961 prqtaghgka vktfwteykp pspsraskrh qrvlatrvrn itkksshlpl gsplkrqqnt
     1021 rdpdtmvplt dfspvmdhsr ekdndlsdtd snysldslsc vyakaliepl kpeerkwdfp
     1081 epensesdds qlsedslaek ryqspknrlg gnrptnnrgq prtrtrasvr gftaasdsdl
     1141 laqthrsfsl dslidaeeel gedqqeepfp gsadeiptet fwhledsslp vmdqeaicrl
     1201 gpinyrtaar ldavlpmsss fyldpqfqph celqphcelq phcelqphce qaesqvepsy
     1261 seqadslqgm qlsresplms mdswfscdsk inpssppgiv gslcpspdmq efhsckgerp
     1321 gywpnteelk psdaetvlpy ssklhqgste llcsardeht asaadtsrls lwgiqrliqp
     1381 gadgtfqgrc ipdmtqqgss eashnssvsn vlaasattlt hvgstherdw salqqkylle
     1441 lscpvleaig apkpaypyle edsgslaqas skggdtllpv gprvssnlnl nnfpvhlsri
     1501 rrlraekeqd slnaklegvs dffstsekea sydetysadl eslsasrstn aqvfatenai
     1561 pdsmteacev kqnnleeclq scrkpglmts sdedffqkna chsnvttatk adhwsqgwap
     1621 lrknsavqpg qlspdshypl eeektdcqes skeavrrhin vsfalpsgpe lylhsapwnp
     1681 lssslqppll etfyvtksrd altetaleip acrevrvpsp ppreawgfgh nhqalqgayl
     1741 knnlpvllqn qnskiassqq vtaeipvdln treviresgk cpgniteesh dsvyssvtqn
     1801 rhflpststk vcefenqvvi lnkkhsfpal eggevtaqsc cgassdstes gksllfrese
     1861 areeeeldqn tvlrqtinvs lekdmpgesa vslksrsvdr rvsspvmvaq gggptpkweg
     1921 knetgllekg lrpkdsseef klpgtkpaye rfqlvacpqe rnpsecksqe mlnpnrepsg
     1981 kkqnkrvnnt demarlirsv mqlengilei eskqnkqvha shtpgtdkel vfqdqkeqek
     2041 tdhafrpdss gnplpskdqp ssprqtddtv frdseagame vnsignhpqv qkitpnpfrs
     2101 regvresepv rehthpagsd rpardicdsl gkhttcreft ntslhpqrmk alaralplqp
     2161 rlerssknng qfvkasaslk gqpwglgsle eletvkgfqe sqvaehvsss nqeepkaqgk
     2221 veempmqrgg slqeenkvtq kfpslsqlcr dtffrqetvs pllsrtefct aplhqdlsnt
     2281 lplnsprwpr rclhvpvalg issldcvldl tmlkihnspl vtgvehqdqs tetrshspeg
     2341 nvrgrsseah tawcgsvrsm amgshsqsgv pesiplgted risastspqd hgkdlritll
     2401 gfstsedfas eaevavqkei rvsslnkvss qpekrvsfsl eedsdqaskp rqkaeketed
     2461 vgltsgvsla pvslprvpsp eprllepsdh asmclailee irqakaqrkq lhdfvargtv
     2521 lsycetllep ecssrvagrp qckqidqsss dqtrnegeap gfhvaslsae agqidllpde
     2581 rkvqatslsa dsfeslpnte tdrepwdpvq afshaapaqd rkrrtgelrq fagasepfic
     2641 hsssseiiek kkdatrtpss adplapdspr ssapveevrr vvskkvvaal psqapyddpr
     2701 vtlhelsqsv pqetaegipp gsqdsspehq eprtldttyg evsdnllvta qgektahfes
     2761 qsvtcdvqns tsasgpkqdh vqcpeastgf eegraspkqd tilpgaltrv aleaptqqcv
     2821 qckesvgsgl tevcragskh srpiplpdqr psanpggige eapcrhprea ldgpvfsrnp
     2881 egsrtlspsr gkesrtlpcr qpcssqpvat haysshsstl lcfrdgdlgk epfkaaphti
     2941 hppcvvpsra yemdetgeis rgpdvhlthg lepkdvnref rltesstcep stvaavlsra
     3001 qgcrspsapd vrtgsfshsa tdgsvgligv pekkvaekqa steleaasfp agmyseplrq
     3061 frdssvgdqn aqvcqtnpep pattqgphtl dlsegsaesk lvvepqhecl enttrcflek
     3121 pqfstelrdh nrldsqakfv arlkhtcspq edspwqeeeq hrdqasggge gfaqgvnplp
     3181 dedgldgcqi ldagreevav akppvskils qgfkdpatvs lrqnetpqpa aqrsghlytg
     3241 reqpapnhrg slpvttifsg pkhsrssptp qfsvvgssrs lqelnlsvep psptdedtqg
     3301 pnrlwnphlr gyssgksvar tslqaedsnq kassrlddgt tdhrhlkpat ppypmpstls
     3361 hmptpdftts wmsgtleqaq qgkreklgvq vrpenwcsqm dkgmlhfgss dispyalpwr
     3421 peepariswk qymsgsavdv scsqkpqglt lsnvarcssm dngledqnsp fhshlstyan
     3481 icdlstthss tenaqgsnea wevfrgsssi algdphipts pegvaptsgh drrpqfrgps
     3541 geadclrskp plakgsaagp vdeimllyps eagcpvgqtr tntfeqgtqt lgsrrhwsst
     3601 disfaqpeas avsafdlasw tsmhnlslhl sqllhstsel lgslsqpdva rreqntkrdi
     3661 pdkapqalmm dgstqttvde gsqtdltlpt lclqtseaep qganvilegl gsdtstvsqe
     3721 egdvpgvpqk reaeetaqkm aqllylqees tpykpqspsi psshlrfqka pvgqhlpsvs
     3781 psvsdaflpp ssqpeesycl vvsspspssp hspglfpsts eypgdsrvqk klgptsalfv
     3841 drasspiltl sastqepgls pgsltlsaps thpveghqkl dsspdpvdap rtpmdnysqt
     3901 tdelggsqrg rsslqrsngr sflelhsphs pqqspklqfs flgqhpqqlq prttigvqsr
     3961 llppplrhrs qrlgnsfvpe kvaspehcpl sgrepsqwqs rtenggessa spgepqrtld
     4021 rpsswgglqh lspcpvselt dtaglrgsal glpqacqpee llcfscqmcm apehqhhslr
     4081 dlpvhnkfsn wcgvqkgspg gldmteeelg asgdlssekq eqsppqppnd hsqdsewskr
     4141 eqiplqvgaq nlslsvelte aklhhgfgea dallqvlqsg tgealaadep vtstwkelya
     4201 rqkkaietlr reraerlgnf crtrslspqk qlsllpnkdl fiwdldlpsr rreylqqlrk
     4261 dvvettrspe svsrsahtps dielmlqdyq qaheeakvei arardqlrer teqeklrihq
     4321 kiisqllkee dklhtlanss slctssngsl ssgmtsgyns spalsgqlqf penmghtnlp
     4381 dsrdvwigde rgghsavrkn sayshraslg scccspssls slgtcfsssy qdlakhvvdt
     4441 smadvmaacs dnlhnlfscq atagwnyqge eqavqlyykv fsptrhgflg agvvsqplsr
     4501 vwaavsdptv wplyykpiqt arlhqrvtns islvylvcnt tlcalkqprd fccvcveake
     4561 vpalvghlsv maaqsvydts mprpsrkmvr geilpsawil qpitvegkev trviylaqve
     4621 lgapgfppql lssfikrqpl viarlasflg r
//
LOCUS       XP_016877929            4651 aa            linear   PRI 05-AUG-2025
DEFINITION  stAR-related lipid transfer protein 9 isoform X8 [Homo sapiens].
ACCESSION   XP_016877929
VERSION     XP_016877929.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022440.2
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 1% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4651
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4651
                     /product="stAR-related lipid transfer protein 9 isoform
                     X8"
                     /calculated_mol_wt=510680
     Region          1..337
                     /region_name="Motor_domain"
                     /note="Myosin and Kinesin motor domain; cl22853"
                     /db_xref="CDD:473979"
     Site            order(49..56,159..160,199..204)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276814"
     Region          336..447
                     /region_name="Kinesin_assoc"
                     /note="Kinesin-associated; pfam16183"
                     /db_xref="CDD:465047"
     Region          417..535
                     /region_name="FHA_KIF16A_STARD9"
                     /note="forkhead associated (FHA) domain found in
                     StAR-related lipid transfer protein 9 (StARD9); cd22731"
                     /db_xref="CDD:438783"
     Region          <526..>732
                     /region_name="COG4913"
                     /note="Uncharacterized conserved protein, contains a
                     C-terminal ATPase domain [Function unknown]"
                     /db_xref="CDD:443941"
     Region          4442..4651
                     /region_name="START_STARD9-like"
                     /note="C-terminal START domain of mammalian STARD9, and
                     related domains; lipid binding; cd08874"
                     /db_xref="CDD:176883"
     Site            order(4468..4469,4476,4488,4490,4501,4505,4511,4514..4515,
                     4517..4518,4537,4539..4542,4546,4549,4551,4553,4573,4591,
                     4593..4596,4598,4613,4615,4617,4619,4621,4623,4626,
                     4628..4630,4634..4635,4639..4640,4643)
                     /site_type="other"
                     /note="putative lipid binding site [chemical binding]"
                     /db_xref="CDD:176883"
     CDS             1..4651
                     /gene="STARD9"
                     /gene_synonym="KIF16A"
                     /coded_by="XM_017022440.2:203..14158"
                     /db_xref="GeneID:57519"
                     /db_xref="HGNC:HGNC:19162"
                     /db_xref="MIM:614642"
ORIGIN      
        1 mafgfdycyw svnpedpqya sqdvvfqdlg mevlsgvakg yniclfaygq tgsgktytml
       61 gtpasvgltp riceglfvre kdcaslpssc rikvsfleiy nervrdllkq sgqkksytlr
      121 vrehpemgpy vqglsqhvvt nykqviqlle egianritaa thvheassrs haiftihytq
      181 ailennlpse maskinlvdl agseradpsy ckdriaegan inkslvtlgi vistlaqnsq
      241 vfsscqslns svsnggdsgi lsspsgtssg gapsrrqsyi pyrdsvltwl lkdslggnsk
      301 timvatvspa htsysetmst lryassakni inkprvneda nlklirelre eierlkalll
      361 sfelrnfssl sdenlkelvl qnelkidqlt kdwtqkwndw qalmehysvd inrrragvvi
      421 dsslphlmal eddvlstgvv lyhlkegttk igridsdqeq divlqgqwie rdhctitsac
      481 gvvvlrparg arctvngrev tascrltqga vitlgkaqkf rfnhpaeaav lrqrrqvgea
      541 aagrgslewl dldgdlaasr lglspllwke rraleeqcde dhqtprdget shraqiqqqq
      601 syvedlrhqi laeeiraake lefdqawisq qikenqqcll reetwlaslq qqqqedqvae
      661 keleasvald awlqtdpeiq pspfvqsqkr vvhlqllrrh tlraaernvr rkkvsfqler
      721 iikkqrllea qkrleklttl cwlqddstqe ppyqvlspda tvprppcrsk ltscsslspq
      781 rlcskhmpql hsiflswdps ttlpprpdpt hqtsektsse ehlpqaasyp artgclrkng
      841 lhssghgqpc taraalarkg asapdacltm spnsvgiqem emgvkqphqm vsqglaslrk
      901 sanklkprhe pkiftsttqt rgakgladps htqagwrkeg nlgthkaakg ascnslyphg
      961 prqtaghgka vktfwteykp pspsraskrh qrvlatrvrn itkksshlpl gsplkrqqnt
     1021 rdpdtmvplt dfspvmdhsr ekdndlsdtd snysldslsc vyakaliepl kpeerkwdfp
     1081 epensesdds qlsedslaek ryqspknrlg gnrptnnrgq prtrtrasvr gftaasdsdl
     1141 laqthrsfsl dslidaeeel gedqqeepfp gsadeiptet fwhledsslp vmdqeaicrl
     1201 gpinyrtaar ldavlpmsss fyldpqfqph celqphcelq phcelqphce qaesqvepsy
     1261 seqadslqgm qlsresplms mdswfscdsk inpssppgiv gslcpspdmq efhsckgerp
     1321 gywpnteelk psdaetvlpy ssklhqgste llcsardeht asaadtsrls lwgiqrliqp
     1381 gadgtfqgrc ipdmtqqgss eashnssvsn vlaasattlt hvgstherdw salqqkylle
     1441 lscpvleaig apkpaypyle edsgslaqas skggdtllpv gprvssnlnl nnfpvhlsri
     1501 rrlraekeqd slnaklegvs dffstsekea sydetysadl eslsasrstn aqvfatenai
     1561 pdsmteacev kqnnleeclq scrkpglmts sdedffqkna chsnvttatk adhwsqgwap
     1621 lrknsavqpg qlspdshypl eeektdcqes skeavrrhin vsfalpsgpe lylhsapwnp
     1681 lssslqppll etfyvtksrd altetaleip acrevrvpsp ppreawgfgh nhqalqgayl
     1741 knnlpvllqn qnskiassqq vtaeipvdln treviresgk cpgniteesh dsvyssvtqn
     1801 rhflpststk vcefenqvvi lnkkhsfpal eggevtaqsc cgassdstes gksllfrese
     1861 areeeeldqn tvlrqtinvs lekdmpgesa vslksrsvdr rvsspvmvaq gggptpkweg
     1921 knetgllekg lrpkdsseef klpgtkpaye rfqlvacpqe rnpsecksqe mlnpnrepsg
     1981 kkqnkrvnnt demarlirsv mqlengilei eskqnkqvha shtpgtdkel vfqdqkeqek
     2041 tdhafrpdss gnplpskdqp ssprqtddtv frdseagame vnsignhpqv qkitpnpfrs
     2101 regvresepv rehthpagsd rpardicdsl gkhttcreft ntslhpqrmk alaralplqp
     2161 rlerssknng qfvkasaslk gqpwglgsle eletvkgfqe sqvaehvsss nqeepkaqgk
     2221 veempmqrgg slqeenkvtq kfpslsqlcr dtffrqetvs pllsrtefct aplhqdlsnt
     2281 lplnsprwpr rclhvpvalg issldcvldl tmlkihnspl vtgvehqdqs tetrshspeg
     2341 nvrgrsseah tawcgsvrsm amgshsqsgv pesiplgted risastspqd hgkdlritll
     2401 gfstsedfas eaevavqkei rvsslnkvss qpekrvsfsl eedsdqaskp rqkaeketed
     2461 vgltsgvsla pvslprvpsp eprllepsdh asmclailee irqakaqrkq lhdfvargtv
     2521 lsycetllep ecssrvagrp qckqidqsss dqtrnegeap gfhvaslsae agqidllpde
     2581 rkvqatslsa dsfeslpnte tdrepwdpvq afshaapaqd rkrrtgelrq fagasepfic
     2641 hsssseiiek kkdatrtpss adplapdspr ssapveevrr vvskkvvaal psqapyddpr
     2701 vtlhelsqsv pqetaegipp gsqdsspehq eprtldttyg evsdnllvta qgektahfes
     2761 qsvtcdvqns tsasgpkqdh vqcpeastgf eegraspkqd tilpgaltrv aleaptqqcv
     2821 qckesvgsgl tevcragskh srpiplpdqr psanpggige eapcrhprea ldgpvfsrnp
     2881 egsrtlspsr gkesrtlpcr qpcssqpvat haysshsstl lcfrdgdlgk epfkaaphti
     2941 hppcvvpsra yemdetgeis rgpdvhlthg lepkdvnref rltesstcep stvaavlsra
     3001 qgcrspsapd vrtgsfshsa tdgsvgligv pekkvaekqa steleaasfp agmyseplrq
     3061 frdssvgdqn aqvcqtnpep pattqgphtl dlsegsaesk lvvepqhecl enttrcflek
     3121 pqfstelrdh nrldsqakfv arlkhtcspq edspwqeeeq hrdqasggge gfaqgvnplp
     3181 dedgldgcqi ldagreevav akppvskils qgfkdpatvs lrqnetpqpa aqrsghlytg
     3241 reqpapnhrg slpvttifsg pkhsrssptp qfsvvgssrs lqelnlsvep psptdedtqg
     3301 pnrlwnphlr gyssgksvar tslqaedsnq kassrlddgt tdhrhlkpat ppypmpstls
     3361 hmptpdftts wmsgtleqaq qgkreklgvq vrpenwcsqm dkgmlhfgss dispyalpwr
     3421 peepariswk qymsgsavdv scsqkpqglt lsnvarcssm dngledqnsp fhshlstyan
     3481 icdlstthss tenaqgsnea wevfrgsssi algdphipts pegvaptsgh drrpqfrgps
     3541 geadclrskp plakgsaagp vdeimllyps eagcpvgqtr tntfeqgtqt lgsrrhwsst
     3601 disfaqpeas avsafdlasw tsmhnlslhl sqllhstsel lgslsqpdva rreqntkrdi
     3661 pdkapqalmm dgstqttvde gsqtdltlpt lclqtseaep qganvilegl gsdtstvsqe
     3721 egdvpgvpqk reaeetaqkm aqllylqees tpykpqspsi psshlrfqka pvgqhlpsvs
     3781 psvsdaflpp ssqpeesycl vvsspspssp hspglfpsts eypgdsrvqk klgptsalfv
     3841 drasspiltl sastqepgls pgsltlsaps thpveghqkl dsspdpvdap rtpmdnysqt
     3901 tdelggsqrg rsslqrsngr sflelhsphs pqqspklqfs flgqhpqqlq prttigvqsr
     3961 llppplrhrs qrlgnsfvpe kvaspehcpl sgrepsqwqs rtenggessa spgepqrtld
     4021 rpsswgglqh lspcpvselt dtaglrgsal glpqacqpee llcfscqmcm apehqhhslr
     4081 dlpvhnkfsn wcgvqkgspg gldmteeelg asgdlssekq eqsppqppnd hsqdsewskr
     4141 eqiplqvgaq nlslsvelte aklhhgfgea dallqvlqsg tgealaadep vtstwkelya
     4201 rqkkaietlr reraerlgnf crtrslspqk qlsllpnkdl fiwdldlpsr rreylqqlrk
     4261 dvvettrspe svsrsahtps dielmlqdyq qaheeakvei arardqlrer teqeklrihq
     4321 kiisqllkee dklhtlanss slctssngsl ssgmtsgyns spalsgqlqf penmghtnlp
     4381 dsrdvwigde rgghsavrkn sayshraslg scccspssls slgtcfsssy qdlakhvvdt
     4441 smadvmaacs dnlhnlfscq atagwnyqge eqavqlyykv fsptrhgflg agvvsqplsr
     4501 vwaavsdptv wplyykpiqt arlhqrvtns islvylvcnt tlcalkqprd fccvcveake
     4561 vpalvghlsv maaqsvydts mprpsrkmvr geilpsawil qpitvegkev trviylaqve
     4621 lgapgfppql lssfikrqpl viarlasflg r
//
LOCUS       XP_047288858            4647 aa            linear   PRI 05-AUG-2025
DEFINITION  stAR-related lipid transfer protein 9 isoform X9 [Homo sapiens].
ACCESSION   XP_047288858
VERSION     XP_047288858.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432902.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4647
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4647
                     /product="stAR-related lipid transfer protein 9 isoform
                     X9"
                     /calculated_mol_wt=510001
     Region          2..380
                     /region_name="Motor_domain"
                     /note="Myosin and Kinesin motor domain; cl22853"
                     /db_xref="CDD:473979"
     Site            order(11..12,103..110,202..203,242..247)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276814"
     Region          413..531
                     /region_name="FHA_KIF16A_STARD9"
                     /note="forkhead associated (FHA) domain found in
                     StAR-related lipid transfer protein 9 (StARD9); cd22731"
                     /db_xref="CDD:438783"
     Region          <522..>728
                     /region_name="COG4913"
                     /note="Uncharacterized conserved protein, contains a
                     C-terminal ATPase domain [Function unknown]"
                     /db_xref="CDD:443941"
     Region          4438..4647
                     /region_name="START_STARD9-like"
                     /note="C-terminal START domain of mammalian STARD9, and
                     related domains; lipid binding; cd08874"
                     /db_xref="CDD:176883"
     Site            order(4464..4465,4472,4484,4486,4497,4501,4507,4510..4511,
                     4513..4514,4533,4535..4538,4542,4545,4547,4549,4569,4587,
                     4589..4592,4594,4609,4611,4613,4615,4617,4619,4622,
                     4624..4626,4630..4631,4635..4636,4639)
                     /site_type="other"
                     /note="putative lipid binding site [chemical binding]"
                     /db_xref="CDD:176883"
     CDS             1..4647
                     /gene="STARD9"
                     /gene_synonym="KIF16A"
                     /coded_by="XM_047432902.1:111..14054"
                     /db_xref="GeneID:57519"
                     /db_xref="HGNC:HGNC:19162"
                     /db_xref="MIM:614642"
ORIGIN      
        1 manvqvavrv rplskretke ggriivevdg kvakirnlkv dnrpdgfgds rekvmafgfd
       61 ycywsvnped pqyasqdvvf qdlgmevlsg vakgyniclf aygqtgsgkt ytmlgtpglf
      121 vrekdcaslp sscrikvsfl eiynervrdl lkqsgqkksy tlrvrehpem gpyvqglsqh
      181 vvtnykqviq lleegianri taathvheas srshaiftih ytqailennl psemaskinl
      241 vdlagserad psyckdriae ganinkslvt lgivistlaq nsqvfsscqs lnssvsnggd
      301 sgilsspsgt ssggapsrrq syipyrdsvl twllkdslgg nsktimvatv spahtsyset
      361 mstlryassa kniinkprvn eidqltkdwt qkwndwqalm ehysvdinrr ragvvidssl
      421 phlmaleddv lstgvvlyhl kegttkigri dsdqeqdivl qgqwierdhc titsacgvvv
      481 lrpargarct vngrevtasc rltqgavitl gkaqkfrfnh paeaavlrqr rqvgeaaagr
      541 gslewldldg dlaasrlgls pllwkerral eeqcdedhqt prdgetshra qiqqqqsyve
      601 dlrhqilaee iraakelefd qawisqqike nqqcllreet wlaslqqqqq edqvaekele
      661 asvaldawlq tdpeiqpspf vqsqkrvvhl qllrrhtlra aernvrrkkv sfqleriikk
      721 qrlleaqkrl eklttlcwlq ddstqeppyq vlspdatvpr ppcrskltsc sslspqrlcs
      781 khmpqlhsif lswdpsttlp prpdpthqts ektsseehlp qaasypartg clrknglhss
      841 ghgqpctara alarkgasap dacltmspns vgiqememgv kqphqmvsqg laslrksank
      901 lkprhepkif tsttqtrgak gladpshtqa gwrkegnlgt hkaakgascn slyphgprqt
      961 aghgkavktf wteykppsps raskrhqrvl atrvrnitkk sshlplgspl krqqntrdpd
     1021 tmvpltdfsp vmdhsrekdn dlsdtdsnys ldslscvyak alieplkpee rkwdfpepen
     1081 sesddsqlse dslaekryqs pknrlggnrp tnnrgqprtr trasvrgfta asdsdllaqt
     1141 hrsfsldsli daeeelgedq qeepfpgsad eiptetfwhl edsslpvmdq eaicrlgpin
     1201 yrtaarldav lpmsssfyld pqfqphcelq phcelqphce lqphceqaes qvepsyseqa
     1261 dslqgmqlsr esplmsmdsw fscdskinps sppgivgslc pspdmqefhs ckgerpgywp
     1321 nteelkpsda etvlpysskl hqgstellcs ardehtasaa dtsrlslwgi qrliqpgadg
     1381 tfqgrcipdm tqqgsseash nssvsnvlaa sattlthvgs therdwsalq qkyllelscp
     1441 vleaigapkp aypyleedsg slaqasskgg dtllpvgprv ssnlnlnnfp vhlsrirrlr
     1501 aekeqdslna klegvsdffs tsekeasyde tysadlesls asrstnaqvf atenaipdsm
     1561 teacevkqnn leeclqscrk pglmtssded ffqknachsn vttatkadhw sqgwaplrkn
     1621 savqpgqlsp dshypleeek tdcqesskea vrrhinvsfa lpsgpelylh sapwnplsss
     1681 lqpplletfy vtksrdalte taleipacre vrvpspppre awgfghnhqa lqgaylknnl
     1741 pvllqnqnsk iassqqvtae ipvdlntrev iresgkcpgn iteeshdsvy ssvtqnrhfl
     1801 pststkvcef enqvvilnkk hsfpalegge vtaqsccgas sdstesgksl lfresearee
     1861 eeldqntvlr qtinvslekd mpgesavslk srsvdrrvss pvmvaqgggp tpkwegknet
     1921 gllekglrpk dsseefklpg tkpayerfql vacpqernps ecksqemlnp nrepsgkkqn
     1981 krvnntdema rlirsvmqle ngileieskq nkqvhashtp gtdkelvfqd qkeqektdha
     2041 frpdssgnpl pskdqpsspr qtddtvfrds eagamevnsi gnhpqvqkit pnpfrsregv
     2101 resepvreht hpagsdrpar dicdslgkht tcreftntsl hpqrmkalar alplqprler
     2161 ssknngqfvk asaslkgqpw glgsleelet vkgfqesqva ehvsssnqee pkaqgkveem
     2221 pmqrggslqe enkvtqkfps lsqlcrdtff rqetvsplls rtefctaplh qdlsntlpln
     2281 sprwprrclh vpvalgissl dcvldltmlk ihnsplvtgv ehqdqstetr shspegnvrg
     2341 rsseahtawc gsvrsmamgs hsqsgvpesi plgtedrisa stspqdhgkd lritllgfst
     2401 sedfaseaev avqkeirvss lnkvssqpek rvsfsleeds dqaskprqka eketedvglt
     2461 sgvslapvsl prvpspeprl lepsdhasmc laileeirqa kaqrkqlhdf vargtvlsyc
     2521 etllepecss rvagrpqckq idqsssdqtr negeapgfhv aslsaeagqi dllpderkvq
     2581 atslsadsfe slpntetdre pwdpvqafsh aapaqdrkrr tgelrqfaga sepfichsss
     2641 seiiekkkda trtpssadpl apdsprssap veevrrvvsk kvvaalpsqa pyddprvtlh
     2701 elsqsvpqet aegippgsqd sspehqeprt ldttygevsd nllvtaqgek tahfesqsvt
     2761 cdvqnstsas gpkqdhvqcp eastgfeegr aspkqdtilp galtrvalea ptqqcvqcke
     2821 svgsgltevc ragskhsrpi plpdqrpsan pggigeeapc rhprealdgp vfsrnpegsr
     2881 tlspsrgkes rtlpcrqpcs sqpvathays shsstllcfr dgdlgkepfk aaphtihppc
     2941 vvpsrayemd etgeisrgpd vhlthglepk dvnrefrlte sstcepstva avlsraqgcr
     3001 spsapdvrtg sfshsatdgs vgligvpekk vaekqastel eaasfpagmy seplrqfrds
     3061 svgdqnaqvc qtnpeppatt qgphtldlse gsaesklvve pqheclentt rcflekpqfs
     3121 telrdhnrld sqakfvarlk htcspqedsp wqeeeqhrdq asgggegfaq gvnplpdedg
     3181 ldgcqildag reevavakpp vskilsqgfk dpatvslrqn etpqpaaqrs ghlytgreqp
     3241 apnhrgslpv ttifsgpkhs rssptpqfsv vgssrslqel nlsveppspt dedtqgpnrl
     3301 wnphlrgyss gksvartslq aedsnqkass rlddgttdhr hlkpatppyp mpstlshmpt
     3361 pdfttswmsg tleqaqqgkr eklgvqvrpe nwcsqmdkgm lhfgssdisp yalpwrpeep
     3421 ariswkqyms gsavdvscsq kpqgltlsnv arcssmdngl edqnspfhsh lstyanicdl
     3481 stthsstena qgsneawevf rgsssialgd phiptspegv aptsghdrrp qfrgpsgead
     3541 clrskpplak gsaagpvdei mllypseagc pvgqtrtntf eqgtqtlgsr rhwsstdisf
     3601 aqpeasavsa fdlaswtsmh nlslhlsqll hstsellgsl sqpdvarreq ntkrdipdka
     3661 pqalmmdgst qttvdegsqt dltlptlclq tseaepqgan vileglgsdt stvsqeegdv
     3721 pgvpqkreae etaqkmaqll ylqeestpyk pqspsipssh lrfqkapvgq hlpsvspsvs
     3781 daflppssqp eesyclvvss pspssphspg lfpstseypg dsrvqkklgp tsalfvdras
     3841 spiltlsast qepglspgsl tlsapsthpv eghqkldssp dpvdaprtpm dnysqttdel
     3901 ggsqrgrssl qrsngrsfle lhsphspqqs pklqfsflgq hpqqlqprtt igvqsrllpp
     3961 plrhrsqrlg nsfvpekvas pehcplsgre psqwqsrten ggessaspge pqrtldrpss
     4021 wgglqhlspc pvseltdtag lrgsalglpq acqpeellcf scqmcmapeh qhhslrdlpv
     4081 hnkfsnwcgv qkgspggldm teeelgasgd lssekqeqsp pqppndhsqd sewskreqip
     4141 lqvgaqnlsl svelteaklh hgfgeadall qvlqsgtgea laadepvtst wkelyarqkk
     4201 aietlrrera erlgnfcrtr slspqkqlsl lpnkdlfiwd ldlpsrrrey lqqlrkdvve
     4261 ttrspesvsr sahtpsdiel mlqdyqqahe eakveiarar dqlrerteqe klrihqkiis
     4321 qllkeedklh tlanssslct ssngslssgm tsgynsspal sgqlqfpenm ghtnlpdsrd
     4381 vwigderggh savrknsays hraslgsccc spsslsslgt cfsssyqdla khvvdtsmad
     4441 vmaacsdnlh nlfscqatag wnyqgeeqav qlyykvfspt rhgflgagvv sqplsrvwaa
     4501 vsdptvwply ykpiqtarlh qrvtnsislv ylvcnttlca lkqprdfccv cveakevpal
     4561 vghlsvmaaq svydtsmprp srkmvrgeil psawilqpit vegkevtrvi ylaqvelgap
     4621 gfppqllssf ikrqplviar lasflgr
//
LOCUS       XP_016877930            4632 aa            linear   PRI 05-AUG-2025
DEFINITION  stAR-related lipid transfer protein 9 isoform X10 [Homo sapiens].
ACCESSION   XP_016877930
VERSION     XP_016877930.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022441.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4632
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4632
                     /product="stAR-related lipid transfer protein 9 isoform
                     X10"
                     /calculated_mol_wt=508515
     Region          <5..318
                     /region_name="Motor_domain"
                     /note="Myosin and Kinesin motor domain; cl22853"
                     /db_xref="CDD:473979"
     Site            order(30..37,140..141,180..185)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276814"
     Region          317..428
                     /region_name="Kinesin_assoc"
                     /note="Kinesin-associated; pfam16183"
                     /db_xref="CDD:465047"
     Region          398..516
                     /region_name="FHA_KIF16A_STARD9"
                     /note="forkhead associated (FHA) domain found in
                     StAR-related lipid transfer protein 9 (StARD9); cd22731"
                     /db_xref="CDD:438783"
     Region          <507..>713
                     /region_name="COG4913"
                     /note="Uncharacterized conserved protein, contains a
                     C-terminal ATPase domain [Function unknown]"
                     /db_xref="CDD:443941"
     Region          4423..4632
                     /region_name="START_STARD9-like"
                     /note="C-terminal START domain of mammalian STARD9, and
                     related domains; lipid binding; cd08874"
                     /db_xref="CDD:176883"
     Site            order(4449..4450,4457,4469,4471,4482,4486,4492,4495..4496,
                     4498..4499,4518,4520..4523,4527,4530,4532,4534,4554,4572,
                     4574..4577,4579,4594,4596,4598,4600,4602,4604,4607,
                     4609..4611,4615..4616,4620..4621,4624)
                     /site_type="other"
                     /note="putative lipid binding site [chemical binding]"
                     /db_xref="CDD:176883"
     CDS             1..4632
                     /gene="STARD9"
                     /gene_synonym="KIF16A"
                     /coded_by="XM_017022441.3:8205..22103"
                     /db_xref="GeneID:57519"
                     /db_xref="HGNC:HGNC:19162"
                     /db_xref="MIM:614642"
ORIGIN      
        1 mwgfkvfqdl gmevlsgvak gyniclfayg qtgsgktytm lgtpasvglt priceglfvr
       61 ekdcaslpss crikvsflei ynervrdllk qsgqkksytl rvrehpemgp yvqglsqhvv
      121 tnykqviqll eegianrita athvheassr shaiftihyt qailennlps emaskinlvd
      181 lagseradps yckdriaega ninkslvtlg ivistlaqns qvfsscqsln ssvsnggdsg
      241 ilsspsgtss ggapsrrqsy ipyrdsvltw llkdslggns ktimvatvsp ahtsysetms
      301 tlryassakn iinkprvned anlklirelr eeierlkall lsfelrnfss lsdenlkelv
      361 lqnelkidql tkdwtqkwnd wqalmehysv dinrrragvv idsslphlma leddvlstgv
      421 vlyhlkegtt kigridsdqe qdivlqgqwi erdhctitsa cgvvvlrpar garctvngre
      481 vtascrltqg avitlgkaqk frfnhpaeaa vlrqrrqvge aaagrgslew ldldgdlaas
      541 rlglspllwk erraleeqcd edhqtprdge tshraqiqqq qsyvedlrhq ilaeeiraak
      601 elefdqawis qqikenqqcl lreetwlasl qqqqqedqva ekeleasval dawlqtdpei
      661 qpspfvqsqk rvvhlqllrr htlraaernv rrkkvsfqle riikkqrlle aqkrlekltt
      721 lcwlqddstq eppyqvlspd atvprppcrs kltscsslsp qrlcskhmpq lhsiflswdp
      781 sttlpprpdp thqtsektss eehlpqaasy partgclrkn glhssghgqp ctaraalark
      841 gasapdaclt mspnsvgiqe memgvkqphq mvsqglaslr ksanklkprh epkiftsttq
      901 trgakgladp shtqagwrke gnlgthkaak gascnslyph gprqtaghgk avktfwteyk
      961 ppspsraskr hqrvlatrvr nitkksshlp lgsplkrqqn trdpdtmvpl tdfspvmdhs
     1021 rekdndlsdt dsnysldsls cvyakaliep lkpeerkwdf pepensesdd sqlsedslae
     1081 kryqspknrl ggnrptnnrg qprtrtrasv rgftaasdsd llaqthrsfs ldslidaeee
     1141 lgedqqeepf pgsadeipte tfwhledssl pvmdqeaicr lgpinyrtaa rldavlpmss
     1201 sfyldpqfqp hcelqphcel qphcelqphc eqaesqveps yseqadslqg mqlsresplm
     1261 smdswfscds kinpssppgi vgslcpspdm qefhsckger pgywpnteel kpsdaetvlp
     1321 yssklhqgst ellcsardeh tasaadtsrl slwgiqrliq pgadgtfqgr cipdmtqqgs
     1381 seashnssvs nvlaasattl thvgstherd wsalqqkyll elscpvleai gapkpaypyl
     1441 eedsgslaqa sskggdtllp vgprvssnln lnnfpvhlsr irrlraekeq dslnaklegv
     1501 sdffstseke asydetysad leslsasrst naqvfatena ipdsmteace vkqnnleecl
     1561 qscrkpglmt ssdedffqkn achsnvttat kadhwsqgwa plrknsavqp gqlspdshyp
     1621 leeektdcqe sskeavrrhi nvsfalpsgp elylhsapwn plssslqppl letfyvtksr
     1681 daltetalei pacrevrvps pppreawgfg hnhqalqgay lknnlpvllq nqnskiassq
     1741 qvtaeipvdl ntreviresg kcpgnitees hdsvyssvtq nrhflpstst kvcefenqvv
     1801 ilnkkhsfpa leggevtaqs ccgassdste sgksllfres eareeeeldq ntvlrqtinv
     1861 slekdmpges avslksrsvd rrvsspvmva qgggptpkwe gknetgllek glrpkdssee
     1921 fklpgtkpay erfqlvacpq ernpsecksq emlnpnreps gkkqnkrvnn tdemarlirs
     1981 vmqlengile ieskqnkqvh ashtpgtdke lvfqdqkeqe ktdhafrpds sgnplpskdq
     2041 pssprqtddt vfrdseagam evnsignhpq vqkitpnpfr sregvresep vrehthpags
     2101 drpardicds lgkhttcref tntslhpqrm kalaralplq prlerssknn gqfvkasasl
     2161 kgqpwglgsl eeletvkgfq esqvaehvss snqeepkaqg kveempmqrg gslqeenkvt
     2221 qkfpslsqlc rdtffrqetv spllsrtefc taplhqdlsn tlplnsprwp rrclhvpval
     2281 gissldcvld ltmlkihnsp lvtgvehqdq stetrshspe gnvrgrssea htawcgsvrs
     2341 mamgshsqsg vpesiplgte drisastspq dhgkdlritl lgfstsedfa seaevavqke
     2401 irvsslnkvs sqpekrvsfs leedsdqask prqkaekete dvgltsgvsl apvslprvps
     2461 peprllepsd hasmclaile eirqakaqrk qlhdfvargt vlsycetlle pecssrvagr
     2521 pqckqidqss sdqtrnegea pgfhvaslsa eagqidllpd erkvqatsls adsfeslpnt
     2581 etdrepwdpv qafshaapaq drkrrtgelr qfagasepfi chsssseiie kkkdatrtps
     2641 sadplapdsp rssapveevr rvvskkvvaa lpsqapyddp rvtlhelsqs vpqetaegip
     2701 pgsqdsspeh qeprtldtty gevsdnllvt aqgektahfe sqsvtcdvqn stsasgpkqd
     2761 hvqcpeastg feegraspkq dtilpgaltr valeaptqqc vqckesvgsg ltevcragsk
     2821 hsrpiplpdq rpsanpggig eeapcrhpre aldgpvfsrn pegsrtlsps rgkesrtlpc
     2881 rqpcssqpva thaysshsst llcfrdgdlg kepfkaapht ihppcvvpsr ayemdetgei
     2941 srgpdvhlth glepkdvnre frltesstce pstvaavlsr aqgcrspsap dvrtgsfshs
     3001 atdgsvglig vpekkvaekq asteleaasf pagmyseplr qfrdssvgdq naqvcqtnpe
     3061 ppattqgpht ldlsegsaes klvvepqhec lenttrcfle kpqfstelrd hnrldsqakf
     3121 varlkhtcsp qedspwqeee qhrdqasggg egfaqgvnpl pdedgldgcq ildagreeva
     3181 vakppvskil sqgfkdpatv slrqnetpqp aaqrsghlyt greqpapnhr gslpvttifs
     3241 gpkhsrsspt pqfsvvgssr slqelnlsve ppsptdedtq gpnrlwnphl rgyssgksva
     3301 rtslqaedsn qkassrlddg ttdhrhlkpa tppypmpstl shmptpdftt swmsgtleqa
     3361 qqgkreklgv qvrpenwcsq mdkgmlhfgs sdispyalpw rpeeparisw kqymsgsavd
     3421 vscsqkpqgl tlsnvarcss mdngledqns pfhshlstya nicdlstths stenaqgsne
     3481 awevfrgsss ialgdphipt spegvaptsg hdrrpqfrgp sgeadclrsk pplakgsaag
     3541 pvdeimllyp seagcpvgqt rtntfeqgtq tlgsrrhwss tdisfaqpea savsafdlas
     3601 wtsmhnlslh lsqllhstse llgslsqpdv arreqntkrd ipdkapqalm mdgstqttvd
     3661 egsqtdltlp tlclqtseae pqganvileg lgsdtstvsq eegdvpgvpq kreaeetaqk
     3721 maqllylqee stpykpqsps ipsshlrfqk apvgqhlpsv spsvsdaflp pssqpeesyc
     3781 lvvsspspss phspglfpst seypgdsrvq kklgptsalf vdrasspilt lsastqepgl
     3841 spgsltlsap sthpveghqk ldsspdpvda prtpmdnysq ttdelggsqr grsslqrsng
     3901 rsflelhsph spqqspklqf sflgqhpqql qprttigvqs rllppplrhr sqrlgnsfvp
     3961 ekvaspehcp lsgrepsqwq srtenggess aspgepqrtl drpsswgglq hlspcpvsel
     4021 tdtaglrgsa lglpqacqpe ellcfscqmc mapehqhhsl rdlpvhnkfs nwcgvqkgsp
     4081 ggldmteeel gasgdlssek qeqsppqppn dhsqdsewsk reqiplqvga qnlslsvelt
     4141 eaklhhgfge adallqvlqs gtgealaade pvtstwkely arqkkaietl rreraerlgn
     4201 fcrtrslspq kqlsllpnkd lfiwdldlps rrreylqqlr kdvvettrsp esvsrsahtp
     4261 sdielmlqdy qqaheeakve iarardqlre rteqeklrih qkiisqllke edklhtlans
     4321 sslctssngs lssgmtsgyn sspalsgqlq fpenmghtnl pdsrdvwigd ergghsavrk
     4381 nsayshrasl gscccspssl sslgtcfsss yqdlakhvvd tsmadvmaac sdnlhnlfsc
     4441 qatagwnyqg eeqavqlyyk vfsptrhgfl gagvvsqpls rvwaavsdpt vwplyykpiq
     4501 tarlhqrvtn sislvylvcn ttlcalkqpr dfccvcveak evpalvghls vmaaqsvydt
     4561 smprpsrkmv rgeilpsawi lqpitvegke vtrviylaqv elgapgfppq llssfikrqp
     4621 lviarlasfl gr
//
LOCUS       XP_011520139            4621 aa            linear   PRI 05-AUG-2025
DEFINITION  stAR-related lipid transfer protein 9 isoform X11 [Homo sapiens].
ACCESSION   XP_011520139
VERSION     XP_011520139.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521837.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4621
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4621
                     /product="stAR-related lipid transfer protein 9 isoform
                     X11"
                     /calculated_mol_wt=507206
     Region          <2..307
                     /region_name="Motor_domain"
                     /note="Myosin and Kinesin motor domain; cl22853"
                     /db_xref="CDD:473979"
     Site            order(19..26,129..130,169..174)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276814"
     Region          306..417
                     /region_name="Kinesin_assoc"
                     /note="Kinesin-associated; pfam16183"
                     /db_xref="CDD:465047"
     Region          387..505
                     /region_name="FHA_KIF16A_STARD9"
                     /note="forkhead associated (FHA) domain found in
                     StAR-related lipid transfer protein 9 (StARD9); cd22731"
                     /db_xref="CDD:438783"
     Region          <496..>702
                     /region_name="COG4913"
                     /note="Uncharacterized conserved protein, contains a
                     C-terminal ATPase domain [Function unknown]"
                     /db_xref="CDD:443941"
     Region          4412..4621
                     /region_name="START_STARD9-like"
                     /note="C-terminal START domain of mammalian STARD9, and
                     related domains; lipid binding; cd08874"
                     /db_xref="CDD:176883"
     Site            order(4438..4439,4446,4458,4460,4471,4475,4481,4484..4485,
                     4487..4488,4507,4509..4512,4516,4519,4521,4523,4543,4561,
                     4563..4566,4568,4583,4585,4587,4589,4591,4593,4596,
                     4598..4600,4604..4605,4609..4610,4613)
                     /site_type="other"
                     /note="putative lipid binding site [chemical binding]"
                     /db_xref="CDD:176883"
     CDS             1..4621
                     /gene="STARD9"
                     /gene_synonym="KIF16A"
                     /coded_by="XM_011521837.4:176..14041"
                     /db_xref="GeneID:57519"
                     /db_xref="HGNC:HGNC:19162"
                     /db_xref="MIM:614642"
ORIGIN      
        1 mevlsgvakg yniclfaygq tgsgktytml gtpasvgltp riceglfvre kdcaslpssc
       61 rikvsfleiy nervrdllkq sgqkksytlr vrehpemgpy vqglsqhvvt nykqviqlle
      121 egianritaa thvheassrs haiftihytq ailennlpse maskinlvdl agseradpsy
      181 ckdriaegan inkslvtlgi vistlaqnsq vfsscqslns svsnggdsgi lsspsgtssg
      241 gapsrrqsyi pyrdsvltwl lkdslggnsk timvatvspa htsysetmst lryassakni
      301 inkprvneda nlklirelre eierlkalll sfelrnfssl sdenlkelvl qnelkidqlt
      361 kdwtqkwndw qalmehysvd inrrragvvi dsslphlmal eddvlstgvv lyhlkegttk
      421 igridsdqeq divlqgqwie rdhctitsac gvvvlrparg arctvngrev tascrltqga
      481 vitlgkaqkf rfnhpaeaav lrqrrqvgea aagrgslewl dldgdlaasr lglspllwke
      541 rraleeqcde dhqtprdget shraqiqqqq syvedlrhqi laeeiraake lefdqawisq
      601 qikenqqcll reetwlaslq qqqqedqvae keleasvald awlqtdpeiq pspfvqsqkr
      661 vvhlqllrrh tlraaernvr rkkvsfqler iikkqrllea qkrleklttl cwlqddstqe
      721 ppyqvlspda tvprppcrsk ltscsslspq rlcskhmpql hsiflswdps ttlpprpdpt
      781 hqtsektsse ehlpqaasyp artgclrkng lhssghgqpc taraalarkg asapdacltm
      841 spnsvgiqem emgvkqphqm vsqglaslrk sanklkprhe pkiftsttqt rgakgladps
      901 htqagwrkeg nlgthkaakg ascnslyphg prqtaghgka vktfwteykp pspsraskrh
      961 qrvlatrvrn itkksshlpl gsplkrqqnt rdpdtmvplt dfspvmdhsr ekdndlsdtd
     1021 snysldslsc vyakaliepl kpeerkwdfp epensesdds qlsedslaek ryqspknrlg
     1081 gnrptnnrgq prtrtrasvr gftaasdsdl laqthrsfsl dslidaeeel gedqqeepfp
     1141 gsadeiptet fwhledsslp vmdqeaicrl gpinyrtaar ldavlpmsss fyldpqfqph
     1201 celqphcelq phcelqphce qaesqvepsy seqadslqgm qlsresplms mdswfscdsk
     1261 inpssppgiv gslcpspdmq efhsckgerp gywpnteelk psdaetvlpy ssklhqgste
     1321 llcsardeht asaadtsrls lwgiqrliqp gadgtfqgrc ipdmtqqgss eashnssvsn
     1381 vlaasattlt hvgstherdw salqqkylle lscpvleaig apkpaypyle edsgslaqas
     1441 skggdtllpv gprvssnlnl nnfpvhlsri rrlraekeqd slnaklegvs dffstsekea
     1501 sydetysadl eslsasrstn aqvfatenai pdsmteacev kqnnleeclq scrkpglmts
     1561 sdedffqkna chsnvttatk adhwsqgwap lrknsavqpg qlspdshypl eeektdcqes
     1621 skeavrrhin vsfalpsgpe lylhsapwnp lssslqppll etfyvtksrd altetaleip
     1681 acrevrvpsp ppreawgfgh nhqalqgayl knnlpvllqn qnskiassqq vtaeipvdln
     1741 treviresgk cpgniteesh dsvyssvtqn rhflpststk vcefenqvvi lnkkhsfpal
     1801 eggevtaqsc cgassdstes gksllfrese areeeeldqn tvlrqtinvs lekdmpgesa
     1861 vslksrsvdr rvsspvmvaq gggptpkweg knetgllekg lrpkdsseef klpgtkpaye
     1921 rfqlvacpqe rnpsecksqe mlnpnrepsg kkqnkrvnnt demarlirsv mqlengilei
     1981 eskqnkqvha shtpgtdkel vfqdqkeqek tdhafrpdss gnplpskdqp ssprqtddtv
     2041 frdseagame vnsignhpqv qkitpnpfrs regvresepv rehthpagsd rpardicdsl
     2101 gkhttcreft ntslhpqrmk alaralplqp rlerssknng qfvkasaslk gqpwglgsle
     2161 eletvkgfqe sqvaehvsss nqeepkaqgk veempmqrgg slqeenkvtq kfpslsqlcr
     2221 dtffrqetvs pllsrtefct aplhqdlsnt lplnsprwpr rclhvpvalg issldcvldl
     2281 tmlkihnspl vtgvehqdqs tetrshspeg nvrgrsseah tawcgsvrsm amgshsqsgv
     2341 pesiplgted risastspqd hgkdlritll gfstsedfas eaevavqkei rvsslnkvss
     2401 qpekrvsfsl eedsdqaskp rqkaeketed vgltsgvsla pvslprvpsp eprllepsdh
     2461 asmclailee irqakaqrkq lhdfvargtv lsycetllep ecssrvagrp qckqidqsss
     2521 dqtrnegeap gfhvaslsae agqidllpde rkvqatslsa dsfeslpnte tdrepwdpvq
     2581 afshaapaqd rkrrtgelrq fagasepfic hsssseiiek kkdatrtpss adplapdspr
     2641 ssapveevrr vvskkvvaal psqapyddpr vtlhelsqsv pqetaegipp gsqdsspehq
     2701 eprtldttyg evsdnllvta qgektahfes qsvtcdvqns tsasgpkqdh vqcpeastgf
     2761 eegraspkqd tilpgaltrv aleaptqqcv qckesvgsgl tevcragskh srpiplpdqr
     2821 psanpggige eapcrhprea ldgpvfsrnp egsrtlspsr gkesrtlpcr qpcssqpvat
     2881 haysshsstl lcfrdgdlgk epfkaaphti hppcvvpsra yemdetgeis rgpdvhlthg
     2941 lepkdvnref rltesstcep stvaavlsra qgcrspsapd vrtgsfshsa tdgsvgligv
     3001 pekkvaekqa steleaasfp agmyseplrq frdssvgdqn aqvcqtnpep pattqgphtl
     3061 dlsegsaesk lvvepqhecl enttrcflek pqfstelrdh nrldsqakfv arlkhtcspq
     3121 edspwqeeeq hrdqasggge gfaqgvnplp dedgldgcqi ldagreevav akppvskils
     3181 qgfkdpatvs lrqnetpqpa aqrsghlytg reqpapnhrg slpvttifsg pkhsrssptp
     3241 qfsvvgssrs lqelnlsvep psptdedtqg pnrlwnphlr gyssgksvar tslqaedsnq
     3301 kassrlddgt tdhrhlkpat ppypmpstls hmptpdftts wmsgtleqaq qgkreklgvq
     3361 vrpenwcsqm dkgmlhfgss dispyalpwr peepariswk qymsgsavdv scsqkpqglt
     3421 lsnvarcssm dngledqnsp fhshlstyan icdlstthss tenaqgsnea wevfrgsssi
     3481 algdphipts pegvaptsgh drrpqfrgps geadclrskp plakgsaagp vdeimllyps
     3541 eagcpvgqtr tntfeqgtqt lgsrrhwsst disfaqpeas avsafdlasw tsmhnlslhl
     3601 sqllhstsel lgslsqpdva rreqntkrdi pdkapqalmm dgstqttvde gsqtdltlpt
     3661 lclqtseaep qganvilegl gsdtstvsqe egdvpgvpqk reaeetaqkm aqllylqees
     3721 tpykpqspsi psshlrfqka pvgqhlpsvs psvsdaflpp ssqpeesycl vvsspspssp
     3781 hspglfpsts eypgdsrvqk klgptsalfv drasspiltl sastqepgls pgsltlsaps
     3841 thpveghqkl dsspdpvdap rtpmdnysqt tdelggsqrg rsslqrsngr sflelhsphs
     3901 pqqspklqfs flgqhpqqlq prttigvqsr llppplrhrs qrlgnsfvpe kvaspehcpl
     3961 sgrepsqwqs rtenggessa spgepqrtld rpsswgglqh lspcpvselt dtaglrgsal
     4021 glpqacqpee llcfscqmcm apehqhhslr dlpvhnkfsn wcgvqkgspg gldmteeelg
     4081 asgdlssekq eqsppqppnd hsqdsewskr eqiplqvgaq nlslsvelte aklhhgfgea
     4141 dallqvlqsg tgealaadep vtstwkelya rqkkaietlr reraerlgnf crtrslspqk
     4201 qlsllpnkdl fiwdldlpsr rreylqqlrk dvvettrspe svsrsahtps dielmlqdyq
     4261 qaheeakvei arardqlrer teqeklrihq kiisqllkee dklhtlanss slctssngsl
     4321 ssgmtsgyns spalsgqlqf penmghtnlp dsrdvwigde rgghsavrkn sayshraslg
     4381 scccspssls slgtcfsssy qdlakhvvdt smadvmaacs dnlhnlfscq atagwnyqge
     4441 eqavqlyykv fsptrhgflg agvvsqplsr vwaavsdptv wplyykpiqt arlhqrvtns
     4501 islvylvcnt tlcalkqprd fccvcveake vpalvghlsv maaqsvydts mprpsrkmvr
     4561 geilpsawil qpitvegkev trviylaqve lgapgfppql lssfikrqpl viarlasflg
     4621 r
//
LOCUS       XP_016877931            4467 aa            linear   PRI 05-AUG-2025
DEFINITION  stAR-related lipid transfer protein 9 isoform X12 [Homo sapiens].
ACCESSION   XP_016877931
VERSION     XP_016877931.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022442.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4467
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4467
                     /product="stAR-related lipid transfer protein 9 isoform
                     X12"
                     /calculated_mol_wt=490272
     Region          <19..153
                     /region_name="Motor_domain"
                     /note="Myosin and Kinesin motor domain; cl22853"
                     /db_xref="CDD:473979"
     Region          152..263
                     /region_name="Kinesin_assoc"
                     /note="Kinesin-associated; pfam16183"
                     /db_xref="CDD:465047"
     Region          233..351
                     /region_name="FHA_KIF16A_STARD9"
                     /note="forkhead associated (FHA) domain found in
                     StAR-related lipid transfer protein 9 (StARD9); cd22731"
                     /db_xref="CDD:438783"
     Region          <342..>548
                     /region_name="COG4913"
                     /note="Uncharacterized conserved protein, contains a
                     C-terminal ATPase domain [Function unknown]"
                     /db_xref="CDD:443941"
     Region          4258..4467
                     /region_name="START_STARD9-like"
                     /note="C-terminal START domain of mammalian STARD9, and
                     related domains; lipid binding; cd08874"
                     /db_xref="CDD:176883"
     Site            order(4284..4285,4292,4304,4306,4317,4321,4327,4330..4331,
                     4333..4334,4353,4355..4358,4362,4365,4367,4369,4389,4407,
                     4409..4412,4414,4429,4431,4433,4435,4437,4439,4442,
                     4444..4446,4450..4451,4455..4456,4459)
                     /site_type="other"
                     /note="putative lipid binding site [chemical binding]"
                     /db_xref="CDD:176883"
     CDS             1..4467
                     /gene="STARD9"
                     /gene_synonym="KIF16A"
                     /coded_by="XM_017022442.1:111..13514"
                     /db_xref="GeneID:57519"
                     /db_xref="HGNC:HGNC:19162"
                     /db_xref="MIM:614642"
ORIGIN      
        1 mfmrpaadpt pfsrsttrse radpsyckdr iaeganinks lvtlgivist laqnsqvfss
       61 cqslnssvsn ggdsgilssp sgtssggaps rrqsyipyrd svltwllkds lggnsktimv
      121 atvspahtsy setmstlrya ssakniinkp rvnedanlkl irelreeier lkalllsfel
      181 rnfsslsden lkelvlqnel kidqltkdwt qkwndwqalm ehysvdinrr ragvvidssl
      241 phlmaleddv lstgvvlyhl kegttkigri dsdqeqdivl qgqwierdhc titsacgvvv
      301 lrpargarct vngrevtasc rltqgavitl gkaqkfrfnh paeaavlrqr rqvgeaaagr
      361 gslewldldg dlaasrlgls pllwkerral eeqcdedhqt prdgetshra qiqqqqsyve
      421 dlrhqilaee iraakelefd qawisqqike nqqcllreet wlaslqqqqq edqvaekele
      481 asvaldawlq tdpeiqpspf vqsqkrvvhl qllrrhtlra aernvrrkkv sfqleriikk
      541 qrlleaqkrl eklttlcwlq ddstqeppyq vlspdatvpr ppcrskltsc sslspqrlcs
      601 khmpqlhsif lswdpsttlp prpdpthqts ektsseehlp qaasypartg clrknglhss
      661 ghgqpctara alarkgasap dacltmspns vgiqememgv kqphqmvsqg laslrksank
      721 lkprhepkif tsttqtrgak gladpshtqa gwrkegnlgt hkaakgascn slyphgprqt
      781 aghgkavktf wteykppsps raskrhqrvl atrvrnitkk sshlplgspl krqqntrdpd
      841 tmvpltdfsp vmdhsrekdn dlsdtdsnys ldslscvyak alieplkpee rkwdfpepen
      901 sesddsqlse dslaekryqs pknrlggnrp tnnrgqprtr trasvrgfta asdsdllaqt
      961 hrsfsldsli daeeelgedq qeepfpgsad eiptetfwhl edsslpvmdq eaicrlgpin
     1021 yrtaarldav lpmsssfyld pqfqphcelq phcelqphce lqphceqaes qvepsyseqa
     1081 dslqgmqlsr esplmsmdsw fscdskinps sppgivgslc pspdmqefhs ckgerpgywp
     1141 nteelkpsda etvlpysskl hqgstellcs ardehtasaa dtsrlslwgi qrliqpgadg
     1201 tfqgrcipdm tqqgsseash nssvsnvlaa sattlthvgs therdwsalq qkyllelscp
     1261 vleaigapkp aypyleedsg slaqasskgg dtllpvgprv ssnlnlnnfp vhlsrirrlr
     1321 aekeqdslna klegvsdffs tsekeasyde tysadlesls asrstnaqvf atenaipdsm
     1381 teacevkqnn leeclqscrk pglmtssded ffqknachsn vttatkadhw sqgwaplrkn
     1441 savqpgqlsp dshypleeek tdcqesskea vrrhinvsfa lpsgpelylh sapwnplsss
     1501 lqpplletfy vtksrdalte taleipacre vrvpspppre awgfghnhqa lqgaylknnl
     1561 pvllqnqnsk iassqqvtae ipvdlntrev iresgkcpgn iteeshdsvy ssvtqnrhfl
     1621 pststkvcef enqvvilnkk hsfpalegge vtaqsccgas sdstesgksl lfresearee
     1681 eeldqntvlr qtinvslekd mpgesavslk srsvdrrvss pvmvaqgggp tpkwegknet
     1741 gllekglrpk dsseefklpg tkpayerfql vacpqernps ecksqemlnp nrepsgkkqn
     1801 krvnntdema rlirsvmqle ngileieskq nkqvhashtp gtdkelvfqd qkeqektdha
     1861 frpdssgnpl pskdqpsspr qtddtvfrds eagamevnsi gnhpqvqkit pnpfrsregv
     1921 resepvreht hpagsdrpar dicdslgkht tcreftntsl hpqrmkalar alplqprler
     1981 ssknngqfvk asaslkgqpw glgsleelet vkgfqesqva ehvsssnqee pkaqgkveem
     2041 pmqrggslqe enkvtqkfps lsqlcrdtff rqetvsplls rtefctaplh qdlsntlpln
     2101 sprwprrclh vpvalgissl dcvldltmlk ihnsplvtgv ehqdqstetr shspegnvrg
     2161 rsseahtawc gsvrsmamgs hsqsgvpesi plgtedrisa stspqdhgkd lritllgfst
     2221 sedfaseaev avqkeirvss lnkvssqpek rvsfsleeds dqaskprqka eketedvglt
     2281 sgvslapvsl prvpspeprl lepsdhasmc laileeirqa kaqrkqlhdf vargtvlsyc
     2341 etllepecss rvagrpqckq idqsssdqtr negeapgfhv aslsaeagqi dllpderkvq
     2401 atslsadsfe slpntetdre pwdpvqafsh aapaqdrkrr tgelrqfaga sepfichsss
     2461 seiiekkkda trtpssadpl apdsprssap veevrrvvsk kvvaalpsqa pyddprvtlh
     2521 elsqsvpqet aegippgsqd sspehqeprt ldttygevsd nllvtaqgek tahfesqsvt
     2581 cdvqnstsas gpkqdhvqcp eastgfeegr aspkqdtilp galtrvalea ptqqcvqcke
     2641 svgsgltevc ragskhsrpi plpdqrpsan pggigeeapc rhprealdgp vfsrnpegsr
     2701 tlspsrgkes rtlpcrqpcs sqpvathays shsstllcfr dgdlgkepfk aaphtihppc
     2761 vvpsrayemd etgeisrgpd vhlthglepk dvnrefrlte sstcepstva avlsraqgcr
     2821 spsapdvrtg sfshsatdgs vgligvpekk vaekqastel eaasfpagmy seplrqfrds
     2881 svgdqnaqvc qtnpeppatt qgphtldlse gsaesklvve pqheclentt rcflekpqfs
     2941 telrdhnrld sqakfvarlk htcspqedsp wqeeeqhrdq asgggegfaq gvnplpdedg
     3001 ldgcqildag reevavakpp vskilsqgfk dpatvslrqn etpqpaaqrs ghlytgreqp
     3061 apnhrgslpv ttifsgpkhs rssptpqfsv vgssrslqel nlsveppspt dedtqgpnrl
     3121 wnphlrgyss gksvartslq aedsnqkass rlddgttdhr hlkpatppyp mpstlshmpt
     3181 pdfttswmsg tleqaqqgkr eklgvqvrpe nwcsqmdkgm lhfgssdisp yalpwrpeep
     3241 ariswkqyms gsavdvscsq kpqgltlsnv arcssmdngl edqnspfhsh lstyanicdl
     3301 stthsstena qgsneawevf rgsssialgd phiptspegv aptsghdrrp qfrgpsgead
     3361 clrskpplak gsaagpvdei mllypseagc pvgqtrtntf eqgtqtlgsr rhwsstdisf
     3421 aqpeasavsa fdlaswtsmh nlslhlsqll hstsellgsl sqpdvarreq ntkrdipdka
     3481 pqalmmdgst qttvdegsqt dltlptlclq tseaepqgan vileglgsdt stvsqeegdv
     3541 pgvpqkreae etaqkmaqll ylqeestpyk pqspsipssh lrfqkapvgq hlpsvspsvs
     3601 daflppssqp eesyclvvss pspssphspg lfpstseypg dsrvqkklgp tsalfvdras
     3661 spiltlsast qepglspgsl tlsapsthpv eghqkldssp dpvdaprtpm dnysqttdel
     3721 ggsqrgrssl qrsngrsfle lhsphspqqs pklqfsflgq hpqqlqprtt igvqsrllpp
     3781 plrhrsqrlg nsfvpekvas pehcplsgre psqwqsrten ggessaspge pqrtldrpss
     3841 wgglqhlspc pvseltdtag lrgsalglpq acqpeellcf scqmcmapeh qhhslrdlpv
     3901 hnkfsnwcgv qkgspggldm teeelgasgd lssekqeqsp pqppndhsqd sewskreqip
     3961 lqvgaqnlsl svelteaklh hgfgeadall qvlqsgtgea laadepvtst wkelyarqkk
     4021 aietlrrera erlgnfcrtr slspqkqlsl lpnkdlfiwd ldlpsrrrey lqqlrkdvve
     4081 ttrspesvsr sahtpsdiel mlqdyqqahe eakveiarar dqlrerteqe klrihqkiis
     4141 qllkeedklh tlanssslct ssngslssgm tsgynsspal sgqlqfpenm ghtnlpdsrd
     4201 vwigderggh savrknsays hraslgsccc spsslsslgt cfsssyqdla khvvdtsmad
     4261 vmaacsdnlh nlfscqatag wnyqgeeqav qlyykvfspt rhgflgagvv sqplsrvwaa
     4321 vsdptvwply ykpiqtarlh qrvtnsislv ylvcnttlca lkqprdfccv cveakevpal
     4381 vghlsvmaaq svydtsmprp srkmvrgeil psawilqpit vegkevtrvi ylaqvelgap
     4441 gfppqllssf ikrqplviar lasflgr
//
LOCUS       XP_016877932            4467 aa            linear   PRI 05-AUG-2025
DEFINITION  stAR-related lipid transfer protein 9 isoform X12 [Homo sapiens].
ACCESSION   XP_016877932
VERSION     XP_016877932.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022443.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4467
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4467
                     /product="stAR-related lipid transfer protein 9 isoform
                     X12"
                     /calculated_mol_wt=490272
     Region          <19..153
                     /region_name="Motor_domain"
                     /note="Myosin and Kinesin motor domain; cl22853"
                     /db_xref="CDD:473979"
     Region          152..263
                     /region_name="Kinesin_assoc"
                     /note="Kinesin-associated; pfam16183"
                     /db_xref="CDD:465047"
     Region          233..351
                     /region_name="FHA_KIF16A_STARD9"
                     /note="forkhead associated (FHA) domain found in
                     StAR-related lipid transfer protein 9 (StARD9); cd22731"
                     /db_xref="CDD:438783"
     Region          <342..>548
                     /region_name="COG4913"
                     /note="Uncharacterized conserved protein, contains a
                     C-terminal ATPase domain [Function unknown]"
                     /db_xref="CDD:443941"
     Region          4258..4467
                     /region_name="START_STARD9-like"
                     /note="C-terminal START domain of mammalian STARD9, and
                     related domains; lipid binding; cd08874"
                     /db_xref="CDD:176883"
     Site            order(4284..4285,4292,4304,4306,4317,4321,4327,4330..4331,
                     4333..4334,4353,4355..4358,4362,4365,4367,4369,4389,4407,
                     4409..4412,4414,4429,4431,4433,4435,4437,4439,4442,
                     4444..4446,4450..4451,4455..4456,4459)
                     /site_type="other"
                     /note="putative lipid binding site [chemical binding]"
                     /db_xref="CDD:176883"
     CDS             1..4467
                     /gene="STARD9"
                     /gene_synonym="KIF16A"
                     /coded_by="XM_017022443.1:95..13498"
                     /db_xref="GeneID:57519"
                     /db_xref="HGNC:HGNC:19162"
                     /db_xref="MIM:614642"
ORIGIN      
        1 mfmrpaadpt pfsrsttrse radpsyckdr iaeganinks lvtlgivist laqnsqvfss
       61 cqslnssvsn ggdsgilssp sgtssggaps rrqsyipyrd svltwllkds lggnsktimv
      121 atvspahtsy setmstlrya ssakniinkp rvnedanlkl irelreeier lkalllsfel
      181 rnfsslsden lkelvlqnel kidqltkdwt qkwndwqalm ehysvdinrr ragvvidssl
      241 phlmaleddv lstgvvlyhl kegttkigri dsdqeqdivl qgqwierdhc titsacgvvv
      301 lrpargarct vngrevtasc rltqgavitl gkaqkfrfnh paeaavlrqr rqvgeaaagr
      361 gslewldldg dlaasrlgls pllwkerral eeqcdedhqt prdgetshra qiqqqqsyve
      421 dlrhqilaee iraakelefd qawisqqike nqqcllreet wlaslqqqqq edqvaekele
      481 asvaldawlq tdpeiqpspf vqsqkrvvhl qllrrhtlra aernvrrkkv sfqleriikk
      541 qrlleaqkrl eklttlcwlq ddstqeppyq vlspdatvpr ppcrskltsc sslspqrlcs
      601 khmpqlhsif lswdpsttlp prpdpthqts ektsseehlp qaasypartg clrknglhss
      661 ghgqpctara alarkgasap dacltmspns vgiqememgv kqphqmvsqg laslrksank
      721 lkprhepkif tsttqtrgak gladpshtqa gwrkegnlgt hkaakgascn slyphgprqt
      781 aghgkavktf wteykppsps raskrhqrvl atrvrnitkk sshlplgspl krqqntrdpd
      841 tmvpltdfsp vmdhsrekdn dlsdtdsnys ldslscvyak alieplkpee rkwdfpepen
      901 sesddsqlse dslaekryqs pknrlggnrp tnnrgqprtr trasvrgfta asdsdllaqt
      961 hrsfsldsli daeeelgedq qeepfpgsad eiptetfwhl edsslpvmdq eaicrlgpin
     1021 yrtaarldav lpmsssfyld pqfqphcelq phcelqphce lqphceqaes qvepsyseqa
     1081 dslqgmqlsr esplmsmdsw fscdskinps sppgivgslc pspdmqefhs ckgerpgywp
     1141 nteelkpsda etvlpysskl hqgstellcs ardehtasaa dtsrlslwgi qrliqpgadg
     1201 tfqgrcipdm tqqgsseash nssvsnvlaa sattlthvgs therdwsalq qkyllelscp
     1261 vleaigapkp aypyleedsg slaqasskgg dtllpvgprv ssnlnlnnfp vhlsrirrlr
     1321 aekeqdslna klegvsdffs tsekeasyde tysadlesls asrstnaqvf atenaipdsm
     1381 teacevkqnn leeclqscrk pglmtssded ffqknachsn vttatkadhw sqgwaplrkn
     1441 savqpgqlsp dshypleeek tdcqesskea vrrhinvsfa lpsgpelylh sapwnplsss
     1501 lqpplletfy vtksrdalte taleipacre vrvpspppre awgfghnhqa lqgaylknnl
     1561 pvllqnqnsk iassqqvtae ipvdlntrev iresgkcpgn iteeshdsvy ssvtqnrhfl
     1621 pststkvcef enqvvilnkk hsfpalegge vtaqsccgas sdstesgksl lfresearee
     1681 eeldqntvlr qtinvslekd mpgesavslk srsvdrrvss pvmvaqgggp tpkwegknet
     1741 gllekglrpk dsseefklpg tkpayerfql vacpqernps ecksqemlnp nrepsgkkqn
     1801 krvnntdema rlirsvmqle ngileieskq nkqvhashtp gtdkelvfqd qkeqektdha
     1861 frpdssgnpl pskdqpsspr qtddtvfrds eagamevnsi gnhpqvqkit pnpfrsregv
     1921 resepvreht hpagsdrpar dicdslgkht tcreftntsl hpqrmkalar alplqprler
     1981 ssknngqfvk asaslkgqpw glgsleelet vkgfqesqva ehvsssnqee pkaqgkveem
     2041 pmqrggslqe enkvtqkfps lsqlcrdtff rqetvsplls rtefctaplh qdlsntlpln
     2101 sprwprrclh vpvalgissl dcvldltmlk ihnsplvtgv ehqdqstetr shspegnvrg
     2161 rsseahtawc gsvrsmamgs hsqsgvpesi plgtedrisa stspqdhgkd lritllgfst
     2221 sedfaseaev avqkeirvss lnkvssqpek rvsfsleeds dqaskprqka eketedvglt
     2281 sgvslapvsl prvpspeprl lepsdhasmc laileeirqa kaqrkqlhdf vargtvlsyc
     2341 etllepecss rvagrpqckq idqsssdqtr negeapgfhv aslsaeagqi dllpderkvq
     2401 atslsadsfe slpntetdre pwdpvqafsh aapaqdrkrr tgelrqfaga sepfichsss
     2461 seiiekkkda trtpssadpl apdsprssap veevrrvvsk kvvaalpsqa pyddprvtlh
     2521 elsqsvpqet aegippgsqd sspehqeprt ldttygevsd nllvtaqgek tahfesqsvt
     2581 cdvqnstsas gpkqdhvqcp eastgfeegr aspkqdtilp galtrvalea ptqqcvqcke
     2641 svgsgltevc ragskhsrpi plpdqrpsan pggigeeapc rhprealdgp vfsrnpegsr
     2701 tlspsrgkes rtlpcrqpcs sqpvathays shsstllcfr dgdlgkepfk aaphtihppc
     2761 vvpsrayemd etgeisrgpd vhlthglepk dvnrefrlte sstcepstva avlsraqgcr
     2821 spsapdvrtg sfshsatdgs vgligvpekk vaekqastel eaasfpagmy seplrqfrds
     2881 svgdqnaqvc qtnpeppatt qgphtldlse gsaesklvve pqheclentt rcflekpqfs
     2941 telrdhnrld sqakfvarlk htcspqedsp wqeeeqhrdq asgggegfaq gvnplpdedg
     3001 ldgcqildag reevavakpp vskilsqgfk dpatvslrqn etpqpaaqrs ghlytgreqp
     3061 apnhrgslpv ttifsgpkhs rssptpqfsv vgssrslqel nlsveppspt dedtqgpnrl
     3121 wnphlrgyss gksvartslq aedsnqkass rlddgttdhr hlkpatppyp mpstlshmpt
     3181 pdfttswmsg tleqaqqgkr eklgvqvrpe nwcsqmdkgm lhfgssdisp yalpwrpeep
     3241 ariswkqyms gsavdvscsq kpqgltlsnv arcssmdngl edqnspfhsh lstyanicdl
     3301 stthsstena qgsneawevf rgsssialgd phiptspegv aptsghdrrp qfrgpsgead
     3361 clrskpplak gsaagpvdei mllypseagc pvgqtrtntf eqgtqtlgsr rhwsstdisf
     3421 aqpeasavsa fdlaswtsmh nlslhlsqll hstsellgsl sqpdvarreq ntkrdipdka
     3481 pqalmmdgst qttvdegsqt dltlptlclq tseaepqgan vileglgsdt stvsqeegdv
     3541 pgvpqkreae etaqkmaqll ylqeestpyk pqspsipssh lrfqkapvgq hlpsvspsvs
     3601 daflppssqp eesyclvvss pspssphspg lfpstseypg dsrvqkklgp tsalfvdras
     3661 spiltlsast qepglspgsl tlsapsthpv eghqkldssp dpvdaprtpm dnysqttdel
     3721 ggsqrgrssl qrsngrsfle lhsphspqqs pklqfsflgq hpqqlqprtt igvqsrllpp
     3781 plrhrsqrlg nsfvpekvas pehcplsgre psqwqsrten ggessaspge pqrtldrpss
     3841 wgglqhlspc pvseltdtag lrgsalglpq acqpeellcf scqmcmapeh qhhslrdlpv
     3901 hnkfsnwcgv qkgspggldm teeelgasgd lssekqeqsp pqppndhsqd sewskreqip
     3961 lqvgaqnlsl svelteaklh hgfgeadall qvlqsgtgea laadepvtst wkelyarqkk
     4021 aietlrrera erlgnfcrtr slspqkqlsl lpnkdlfiwd ldlpsrrrey lqqlrkdvve
     4081 ttrspesvsr sahtpsdiel mlqdyqqahe eakveiarar dqlrerteqe klrihqkiis
     4141 qllkeedklh tlanssslct ssngslssgm tsgynsspal sgqlqfpenm ghtnlpdsrd
     4201 vwigderggh savrknsays hraslgsccc spsslsslgt cfsssyqdla khvvdtsmad
     4261 vmaacsdnlh nlfscqatag wnyqgeeqav qlyykvfspt rhgflgagvv sqplsrvwaa
     4321 vsdptvwply ykpiqtarlh qrvtnsislv ylvcnttlca lkqprdfccv cveakevpal
     4381 vghlsvmaaq svydtsmprp srkmvrgeil psawilqpit vegkevtrvi ylaqvelgap
     4441 gfppqllssf ikrqplviar lasflgr
//
LOCUS       XP_047288859            4258 aa            linear   PRI 05-AUG-2025
DEFINITION  stAR-related lipid transfer protein 9 isoform X13 [Homo sapiens].
ACCESSION   XP_047288859
VERSION     XP_047288859.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432903.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4258
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4258
                     /product="stAR-related lipid transfer protein 9 isoform
                     X13"
                     /calculated_mol_wt=466869
     Region          2..391
                     /region_name="KISc_KIF1A_KIF1B"
                     /note="Kinesin motor domain, KIF1_like proteins; cd01365"
                     /db_xref="CDD:276816"
     Site            order(11,103,106,108..111,253)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276816"
     Site            order(337,340,343)
                     /site_type="other"
                     /note="microtubule interaction site [polypeptide binding]"
                     /db_xref="CDD:276816"
     Region          390..501
                     /region_name="Kinesin_assoc"
                     /note="Kinesin-associated; pfam16183"
                     /db_xref="CDD:465047"
     Region          471..589
                     /region_name="FHA_KIF16A_STARD9"
                     /note="forkhead associated (FHA) domain found in
                     StAR-related lipid transfer protein 9 (StARD9); cd22731"
                     /db_xref="CDD:438783"
     Region          <580..>786
                     /region_name="COG4913"
                     /note="Uncharacterized conserved protein, contains a
                     C-terminal ATPase domain [Function unknown]"
                     /db_xref="CDD:443941"
     CDS             1..4258
                     /gene="STARD9"
                     /gene_synonym="KIF16A"
                     /coded_by="XM_047432903.1:111..12887"
                     /db_xref="GeneID:57519"
                     /db_xref="HGNC:HGNC:19162"
                     /db_xref="MIM:614642"
ORIGIN      
        1 manvqvavrv rplskretke ggriivevdg kvakirnlkv dnrpdgfgds rekvmafgfd
       61 ycywsvnped pqyasqdvvf qdlgmevlsg vakgyniclf aygqtgsgkt ytmlgtpasv
      121 gltpricegl fvrekdcasl psscrikvsf leiynervrd llkqsgqkks ytlrvrehpe
      181 mgpyvqglsq hvvtnykqvi qlleegianr itaathvhea ssrshaifti hytqailenn
      241 lpsemaskin lvdlagsera dpsyckdria eganinkslv tlgivistla qnsqvfsscq
      301 slnssvsngg dsgilsspsg tssggapsrr qsyipyrdsv ltwllkdslg gnsktimvat
      361 vspahtsyse tmstlryass akniinkprv nedanlklir elreeierlk alllsfelrn
      421 fsslsdenlk elvlqnelki dqltkdwtqk wndwqalmeh ysvdinrrra gvvidsslph
      481 lmaleddvls tgvvlyhlke gttkigrids dqeqdivlqg qwierdhcti tsacgvvvlr
      541 pargarctvn grevtascrl tqgavitlgk aqkfrfnhpa eaavlrqrrq vgeaaagrgs
      601 lewldldgdl aasrlglspl lwkerralee qcdedhqtpr dgetshraqi qqqqsyvedl
      661 rhqilaeeir aakelefdqa wisqqikenq qcllreetwl aslqqqqqed qvaekeleas
      721 valdawlqtd peiqpspfvq sqkrvvhlql lrrhtlraae rnvrrkkvsf qleriikkqr
      781 lleaqkrlek lttlcwlqdd stqeppyqvl spdatvprpp crskltscss lspqrlcskh
      841 mpqlhsifls wdpsttlppr pdpthqtsek tsseehlpqa asypartgcl rknglhssgh
      901 gqpctaraal arkgasapda cltmspnsvg iqememgvkq phqmvsqgla slrksanklk
      961 prhepkifts ttqtrgakgl adpshtqagw rkegnlgthk aakgascnsl yphgprqtag
     1021 hgkavktfwt eykppspsra skrhqrvlat rvrnitkkss hlplgsplkr qqntrdpdtm
     1081 vpltdfspvm dhsrekdndl sdtdsnysld slscvyakal ieplkpeerk wdfpepense
     1141 sddsqlseds laekryqspk nrlggnrptn nrgqprtrtr asvrgftaas dsdllaqthr
     1201 sfsldslida eeelgedqqe epfpgsadei ptetfwhled sslpvmdqea icrlgpinyr
     1261 taarldavlp msssfyldpq fqphcelqph celqphcelq phceqaesqv epsyseqads
     1321 lqgmqlsres plmsmdswfs cdskinpssp pgivgslcps pdmqefhsck gerpgywpnt
     1381 eelkpsdaet vlpyssklhq gstellcsar dehtasaadt srlslwgiqr liqpgadgtf
     1441 qgrcipdmtq qgsseashns svsnvlaasa ttlthvgsth erdwsalqqk yllelscpvl
     1501 eaigapkpay pyleedsgsl aqasskggdt llpvgprvss nlnlnnfpvh lsrirrlrae
     1561 keqdslnakl egvsdffsts ekeasydety sadleslsas rstnaqvfat enaipdsmte
     1621 acevkqnnle eclqscrkpg lmtssdedff qknachsnvt tatkadhwsq gwaplrknsa
     1681 vqpgqlspds hypleeektd cqesskeavr rhinvsfalp sgpelylhsa pwnplssslq
     1741 pplletfyvt ksrdalteta leipacrevr vpspppreaw gfghnhqalq gaylknnlpv
     1801 llqnqnskia ssqqvtaeip vdlntrevir esgkcpgnit eeshdsvyss vtqnrhflps
     1861 tstkvcefen qvvilnkkhs fpaleggevt aqsccgassd stesgksllf researeeee
     1921 ldqntvlrqt invslekdmp gesavslksr svdrrvsspv mvaqgggptp kwegknetgl
     1981 lekglrpkds seefklpgtk payerfqlva cpqernpsec ksqemlnpnr epsgkkqnkr
     2041 vnntdemarl irsvmqleng ileieskqnk qvhashtpgt dkelvfqdqk eqektdhafr
     2101 pdssgnplps kdqpssprqt ddtvfrdsea gamevnsign hpqvqkitpn pfrsregvre
     2161 sepvrehthp agsdrpardi cdslgkhttc reftntslhp qrmkalaral plqprlerss
     2221 knngqfvkas aslkgqpwgl gsleeletvk gfqesqvaeh vsssnqeepk aqgkveempm
     2281 qrggslqeen kvtqkfpsls qlcrdtffrq etvspllsrt efctaplhqd lsntlplnsp
     2341 rwprrclhvp valgissldc vldltmlkih nsplvtgveh qdqstetrsh spegnvrgrs
     2401 seahtawcgs vrsmamgshs qsgvpesipl gtedrisast spqdhgkdlr itllgfstse
     2461 dfaseaevav qkeirvssln kvssqpekrv sfsleedsdq askprqkaek etedvgltsg
     2521 vslapvslpr vpspeprlle psdhasmcla ileeirqaka qrkqlhdfva rgtvlsycet
     2581 llepecssrv agrpqckqid qsssdqtrne geapgfhvas lsaeagqidl lpderkvqat
     2641 slsadsfesl pntetdrepw dpvqafshaa paqdrkrrtg elrqfagase pfichsssse
     2701 iiekkkdatr tpssadplap dsprssapve evrrvvskkv vaalpsqapy ddprvtlhel
     2761 sqsvpqetae gippgsqdss pehqeprtld ttygevsdnl lvtaqgekta hfesqsvtcd
     2821 vqnstsasgp kqdhvqcpea stgfeegras pkqdtilpga ltrvaleapt qqcvqckesv
     2881 gsgltevcra gskhsrpipl pdqrpsanpg gigeeapcrh prealdgpvf srnpegsrtl
     2941 spsrgkesrt lpcrqpcssq pvathayssh sstllcfrdg dlgkepfkaa phtihppcvv
     3001 psrayemdet geisrgpdvh lthglepkdv nrefrltess tcepstvaav lsraqgcrsp
     3061 sapdvrtgsf shsatdgsvg ligvpekkva ekqastelea asfpagmyse plrqfrdssv
     3121 gdqnaqvcqt npeppattqg phtldlsegs aesklvvepq heclenttrc flekpqfste
     3181 lrdhnrldsq akfvarlkht cspqedspwq eeeqhrdqas gggegfaqgv nplpdedgld
     3241 gcqildagre evavakppvs kilsqgfkdp atvslrqnet pqpaaqrsgh lytgreqpap
     3301 nhrgslpvtt ifsgpkhsrs sptpqfsvvg ssrslqelnl sveppsptde dtqgpnrlwn
     3361 phlrgyssgk svartslqae dsnqkassrl ddgttdhrhl kpatppypmp stlshmptpd
     3421 fttswmsgtl eqaqqgkrek lgvqvrpenw csqmdkgmlh fgssdispya lpwrpeepar
     3481 iswkqymsgs avdvscsqkp qgltlsnvar cssmdngled qnspfhshls tyanicdlst
     3541 thsstenaqg sneawevfrg sssialgdph iptspegvap tsghdrrpqf rgpsgeadcl
     3601 rskpplakgs aagpvdeiml lypseagcpv gqtrtntfeq gtqtlgsrrh wsstdisfaq
     3661 peasavsafd laswtsmhnl slhlsqllhs tsellgslsq pdvarreqnt krdipdkapq
     3721 almmdgstqt tvdegsqtdl tlptlclqts eaepqganvi leglgsdtst vsqeegdvpg
     3781 vpqkreaeet aqkmaqllyl qeestpykpq spsipsshlr fqkapvgqhl psvspsvsda
     3841 flppssqpee syclvvssps pssphspglf pstseypgds rvqkklgpts alfvdrassp
     3901 iltlsastqe pglspgsltl sapsthpveg hqkldsspdp vdaprtpmdn ysqttdelgg
     3961 sqrgrsslqr sngrsflelh sphspqqspk lqfsflgqhp qqlqprttig vqsrllpppl
     4021 rhrsqrlgns fvpekvaspe hcplsgreps qwqsrtengg essaspgepq rtldrpsswg
     4081 glqhlspcpv seltdtaglr gsalglpqac qpeellcfsc qmcmapehqh hslrdlpvhn
     4141 kfsnwcgvqk gspggldmte eelgasgdls sekqeqsppq ppndhsqdse wskreqiplq
     4201 vgaqnlslsv elteaklhhg fgeadallqv lqsgtgeala adepvtstwk elyargqr
//
LOCUS       XP_024305770            1851 aa            linear   PRI 05-AUG-2025
DEFINITION  stAR-related lipid transfer protein 9 isoform X14 [Homo sapiens].
ACCESSION   XP_024305770
VERSION     XP_024305770.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024450002.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1851
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1851
                     /product="stAR-related lipid transfer protein 9 isoform
                     X14"
                     /calculated_mol_wt=205512
     Region          2..391
                     /region_name="KISc_KIF1A_KIF1B"
                     /note="Kinesin motor domain, KIF1_like proteins; cd01365"
                     /db_xref="CDD:276816"
     Site            order(11,103,106,108..111,253)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276816"
     Site            order(337,340,343)
                     /site_type="other"
                     /note="microtubule interaction site [polypeptide binding]"
                     /db_xref="CDD:276816"
     Region          390..501
                     /region_name="Kinesin_assoc"
                     /note="Kinesin-associated; pfam16183"
                     /db_xref="CDD:465047"
     Region          471..589
                     /region_name="FHA_KIF16A_STARD9"
                     /note="forkhead associated (FHA) domain found in
                     StAR-related lipid transfer protein 9 (StARD9); cd22731"
                     /db_xref="CDD:438783"
     Region          <580..>786
                     /region_name="COG4913"
                     /note="Uncharacterized conserved protein, contains a
                     C-terminal ATPase domain [Function unknown]"
                     /db_xref="CDD:443941"
     CDS             1..1851
                     /gene="STARD9"
                     /gene_synonym="KIF16A"
                     /coded_by="XM_024450002.2:111..5666"
                     /db_xref="GeneID:57519"
                     /db_xref="HGNC:HGNC:19162"
                     /db_xref="MIM:614642"
ORIGIN      
        1 manvqvavrv rplskretke ggriivevdg kvakirnlkv dnrpdgfgds rekvmafgfd
       61 ycywsvnped pqyasqdvvf qdlgmevlsg vakgyniclf aygqtgsgkt ytmlgtpasv
      121 gltpricegl fvrekdcasl psscrikvsf leiynervrd llkqsgqkks ytlrvrehpe
      181 mgpyvqglsq hvvtnykqvi qlleegianr itaathvhea ssrshaifti hytqailenn
      241 lpsemaskin lvdlagsera dpsyckdria eganinkslv tlgivistla qnsqvfsscq
      301 slnssvsngg dsgilsspsg tssggapsrr qsyipyrdsv ltwllkdslg gnsktimvat
      361 vspahtsyse tmstlryass akniinkprv nedanlklir elreeierlk alllsfelrn
      421 fsslsdenlk elvlqnelki dqltkdwtqk wndwqalmeh ysvdinrrra gvvidsslph
      481 lmaleddvls tgvvlyhlke gttkigrids dqeqdivlqg qwierdhcti tsacgvvvlr
      541 pargarctvn grevtascrl tqgavitlgk aqkfrfnhpa eaavlrqrrq vgeaaagrgs
      601 lewldldgdl aasrlglspl lwkerralee qcdedhqtpr dgetshraqi qqqqsyvedl
      661 rhqilaeeir aakelefdqa wisqqikenq qcllreetwl aslqqqqqed qvaekeleas
      721 valdawlqtd peiqpspfvq sqkrvvhlql lrrhtlraae rnvrrkkvsf qleriikkqr
      781 lleaqkrlek lttlcwlqdd stqeppyqvl spdatvprpp crskltscss lspqrlcskh
      841 mpqlhsifls wdpsttlppr pdpthqtsek tsseehlpqa asypartgcl rknglhssgh
      901 gqpctaraal arkgasapda cltmspnsvg iqememgvkq phqmvsqgla slrksanklk
      961 prhepkifts ttqtrgakgl adpshtqagw rkegnlgthk aakgascnsl yphgprqtag
     1021 hgkavktfwt eykppspsra skrhqrvlat rvrnitkkss hlplgsplkr qqntrdpdtm
     1081 vpltdfspvm dhsrekdndl sdtdsnysld slscvyakal ieplkpeerk wdfpepense
     1141 sddsqlseds laekryqspk nrlggnrptn nrgqprtrtr asvrgftaas dsdllaqthr
     1201 sfsldslida eeelgedqqe epfpgsadei ptetfwhled sslpvmdqea icrlgpinyr
     1261 taarldavlp msssfyldpq fqphcelqph celqphcelq phceqaesqv epsyseqads
     1321 lqgmqlsres plmsmdswfs cdskinpssp pgivgslcps pdmqefhsck gerpgywpnt
     1381 eelkpsdaet vlpyssklhq gstellcsar dehtasaadt srlslwgiqr liqpgadgtf
     1441 qgrcipdmtq qgsseashns svsnvlaasa ttlthvgsth erdwsalqqk yllelscpvl
     1501 eaigapkpay pyleedsgsl aqasskggdt llpvgprvss nlnlnnfpvh lsrirrlrae
     1561 keqdslnakl egvsdffsts ekeasydety sadleslsas rstnaqvfat enaipdsmte
     1621 acevkqnnle eclqscrkpg lmtssdedff qknachsnvt tatkadhwsq gwaplrknsa
     1681 vqpgqlspds hypleeektd cqesskeavr rhinvsfalp sgpelylhsa pwnplssslq
     1741 pplletfyvt ksrdalteta leipacrevr vpspppreaw gfghnhqalq gaylknnlpv
     1801 llqnqnskia ssqqvtaeip vdlntrevir esgaelecga sfpyrrrytg a
//
LOCUS       XP_011520142             745 aa            linear   PRI 05-AUG-2025
DEFINITION  immunoglobulin superfamily containing leucine-rich repeat protein 2
            isoform X1 [Homo sapiens].
ACCESSION   XP_011520142
VERSION     XP_011520142.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521840.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..745
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..745
                     /product="immunoglobulin superfamily containing
                     leucine-rich repeat protein 2 isoform X1"
                     /calculated_mol_wt=78859
     Region          36..52
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          <51..>183
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          53..76
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          77..100
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          101..124
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          125..148
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          149..172
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          154..>228
                     /region_name="PCC"
                     /note="polycystin cation channel protein; TIGR00864"
                     /db_xref="CDD:188093"
     Region          232..359
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     CDS             1..745
                     /gene="ISLR2"
                     /gene_synonym="LINX"
                     /coded_by="XM_011521840.4:649..2886"
                     /db_xref="GeneID:57611"
                     /db_xref="HGNC:HGNC:29286"
                     /db_xref="MIM:614179"
ORIGIN      
        1 mfplralwlv wallgvagsc pepcacvdky ahqfadcayk elrevpeglp anvttlslsa
       61 nkitvlrrga fadvtqvtsl wlahnevrtv epgalavlsq lknldlshnf issfpwsdlr
      121 nlsalqllkm nhnrlgslpr dalgalpdlr slrinnnrlr tlapgtfdal salshlqlyh
      181 npfhcgcglv wlqawaastr vslpepdsia casppalqgv pvyrlpalpc appsvhlsae
      241 ppleapgtpl raglafvlhc iadghptprl qwqlqipggt vvleppvlsg eddgvgaeeg
      301 egegdgdllt qtqaqtptpa pawpappatp rflalangsl lvpllsakea gvytcrahne
      361 lganstsirv avaatgppkh apgaggepdg qaptserkst akgrgnsvlp skpegkikgq
      421 glakvsilge tetepeedts egeeaedqil adpaeeqrcg ngdpsryvsn hafnqsaelk
      481 phvfelgvia ldvaerearv qltplaarwg pgpggaggap rpgrrplrll ylcpagggaa
      541 vqwsrveegv naywfrglrp gtnysvclal ageachvqvv fstkkelpsl lvivavsvfl
      601 lvlatvpllg aacchllakh pgkpyrlilr pqapdpmekr iaadfdpras yleseksypa
      661 ggeaggeepe dvqgeglded aeqgdpsgdl qreeslaacs lvesqskanq eefeagseys
      721 drlplgaeav niaqeingny rqtag
//
LOCUS       XP_011520143             745 aa            linear   PRI 05-AUG-2025
DEFINITION  immunoglobulin superfamily containing leucine-rich repeat protein 2
            isoform X1 [Homo sapiens].
ACCESSION   XP_011520143
VERSION     XP_011520143.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521841.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..745
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..745
                     /product="immunoglobulin superfamily containing
                     leucine-rich repeat protein 2 isoform X1"
                     /calculated_mol_wt=78859
     Region          36..52
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          <51..>183
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          53..76
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          77..100
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          101..124
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          125..148
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          149..172
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          154..>228
                     /region_name="PCC"
                     /note="polycystin cation channel protein; TIGR00864"
                     /db_xref="CDD:188093"
     Region          232..359
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     CDS             1..745
                     /gene="ISLR2"
                     /gene_synonym="LINX"
                     /coded_by="XM_011521841.2:394..2631"
                     /db_xref="GeneID:57611"
                     /db_xref="HGNC:HGNC:29286"
                     /db_xref="MIM:614179"
ORIGIN      
        1 mfplralwlv wallgvagsc pepcacvdky ahqfadcayk elrevpeglp anvttlslsa
       61 nkitvlrrga fadvtqvtsl wlahnevrtv epgalavlsq lknldlshnf issfpwsdlr
      121 nlsalqllkm nhnrlgslpr dalgalpdlr slrinnnrlr tlapgtfdal salshlqlyh
      181 npfhcgcglv wlqawaastr vslpepdsia casppalqgv pvyrlpalpc appsvhlsae
      241 ppleapgtpl raglafvlhc iadghptprl qwqlqipggt vvleppvlsg eddgvgaeeg
      301 egegdgdllt qtqaqtptpa pawpappatp rflalangsl lvpllsakea gvytcrahne
      361 lganstsirv avaatgppkh apgaggepdg qaptserkst akgrgnsvlp skpegkikgq
      421 glakvsilge tetepeedts egeeaedqil adpaeeqrcg ngdpsryvsn hafnqsaelk
      481 phvfelgvia ldvaerearv qltplaarwg pgpggaggap rpgrrplrll ylcpagggaa
      541 vqwsrveegv naywfrglrp gtnysvclal ageachvqvv fstkkelpsl lvivavsvfl
      601 lvlatvpllg aacchllakh pgkpyrlilr pqapdpmekr iaadfdpras yleseksypa
      661 ggeaggeepe dvqgeglded aeqgdpsgdl qreeslaacs lvesqskanq eefeagseys
      721 drlplgaeav niaqeingny rqtag
//
LOCUS       XP_024305774             745 aa            linear   PRI 05-AUG-2025
DEFINITION  immunoglobulin superfamily containing leucine-rich repeat protein 2
            isoform X1 [Homo sapiens].
ACCESSION   XP_024305774
VERSION     XP_024305774.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024450006.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..745
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..745
                     /product="immunoglobulin superfamily containing
                     leucine-rich repeat protein 2 isoform X1"
                     /calculated_mol_wt=78859
     Region          36..52
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          <51..>183
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          53..76
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          77..100
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          101..124
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          125..148
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          149..172
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          154..>228
                     /region_name="PCC"
                     /note="polycystin cation channel protein; TIGR00864"
                     /db_xref="CDD:188093"
     Region          232..359
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     CDS             1..745
                     /gene="ISLR2"
                     /gene_synonym="LINX"
                     /coded_by="XM_024450006.2:326..2563"
                     /db_xref="GeneID:57611"
                     /db_xref="HGNC:HGNC:29286"
                     /db_xref="MIM:614179"
ORIGIN      
        1 mfplralwlv wallgvagsc pepcacvdky ahqfadcayk elrevpeglp anvttlslsa
       61 nkitvlrrga fadvtqvtsl wlahnevrtv epgalavlsq lknldlshnf issfpwsdlr
      121 nlsalqllkm nhnrlgslpr dalgalpdlr slrinnnrlr tlapgtfdal salshlqlyh
      181 npfhcgcglv wlqawaastr vslpepdsia casppalqgv pvyrlpalpc appsvhlsae
      241 ppleapgtpl raglafvlhc iadghptprl qwqlqipggt vvleppvlsg eddgvgaeeg
      301 egegdgdllt qtqaqtptpa pawpappatp rflalangsl lvpllsakea gvytcrahne
      361 lganstsirv avaatgppkh apgaggepdg qaptserkst akgrgnsvlp skpegkikgq
      421 glakvsilge tetepeedts egeeaedqil adpaeeqrcg ngdpsryvsn hafnqsaelk
      481 phvfelgvia ldvaerearv qltplaarwg pgpggaggap rpgrrplrll ylcpagggaa
      541 vqwsrveegv naywfrglrp gtnysvclal ageachvqvv fstkkelpsl lvivavsvfl
      601 lvlatvpllg aacchllakh pgkpyrlilr pqapdpmekr iaadfdpras yleseksypa
      661 ggeaggeepe dvqgeglded aeqgdpsgdl qreeslaacs lvesqskanq eefeagseys
      721 drlplgaeav niaqeingny rqtag
//
LOCUS       XP_024305773             745 aa            linear   PRI 05-AUG-2025
DEFINITION  immunoglobulin superfamily containing leucine-rich repeat protein 2
            isoform X1 [Homo sapiens].
ACCESSION   XP_024305773
VERSION     XP_024305773.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024450005.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..745
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..745
                     /product="immunoglobulin superfamily containing
                     leucine-rich repeat protein 2 isoform X1"
                     /calculated_mol_wt=78859
     Region          36..52
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          <51..>183
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          53..76
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          77..100
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          101..124
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          125..148
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          149..172
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          154..>228
                     /region_name="PCC"
                     /note="polycystin cation channel protein; TIGR00864"
                     /db_xref="CDD:188093"
     Region          232..359
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     CDS             1..745
                     /gene="ISLR2"
                     /gene_synonym="LINX"
                     /coded_by="XM_024450005.2:401..2638"
                     /db_xref="GeneID:57611"
                     /db_xref="HGNC:HGNC:29286"
                     /db_xref="MIM:614179"
ORIGIN      
        1 mfplralwlv wallgvagsc pepcacvdky ahqfadcayk elrevpeglp anvttlslsa
       61 nkitvlrrga fadvtqvtsl wlahnevrtv epgalavlsq lknldlshnf issfpwsdlr
      121 nlsalqllkm nhnrlgslpr dalgalpdlr slrinnnrlr tlapgtfdal salshlqlyh
      181 npfhcgcglv wlqawaastr vslpepdsia casppalqgv pvyrlpalpc appsvhlsae
      241 ppleapgtpl raglafvlhc iadghptprl qwqlqipggt vvleppvlsg eddgvgaeeg
      301 egegdgdllt qtqaqtptpa pawpappatp rflalangsl lvpllsakea gvytcrahne
      361 lganstsirv avaatgppkh apgaggepdg qaptserkst akgrgnsvlp skpegkikgq
      421 glakvsilge tetepeedts egeeaedqil adpaeeqrcg ngdpsryvsn hafnqsaelk
      481 phvfelgvia ldvaerearv qltplaarwg pgpggaggap rpgrrplrll ylcpagggaa
      541 vqwsrveegv naywfrglrp gtnysvclal ageachvqvv fstkkelpsl lvivavsvfl
      601 lvlatvpllg aacchllakh pgkpyrlilr pqapdpmekr iaadfdpras yleseksypa
      661 ggeaggeepe dvqgeglded aeqgdpsgdl qreeslaacs lvesqskanq eefeagseys
      721 drlplgaeav niaqeingny rqtag
//
LOCUS       XP_024305771             745 aa            linear   PRI 05-AUG-2025
DEFINITION  immunoglobulin superfamily containing leucine-rich repeat protein 2
            isoform X1 [Homo sapiens].
ACCESSION   XP_024305771
VERSION     XP_024305771.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024450003.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..745
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..745
                     /product="immunoglobulin superfamily containing
                     leucine-rich repeat protein 2 isoform X1"
                     /calculated_mol_wt=78859
     Region          36..52
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          <51..>183
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          53..76
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          77..100
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          101..124
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          125..148
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          149..172
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          154..>228
                     /region_name="PCC"
                     /note="polycystin cation channel protein; TIGR00864"
                     /db_xref="CDD:188093"
     Region          232..359
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     CDS             1..745
                     /gene="ISLR2"
                     /gene_synonym="LINX"
                     /coded_by="XM_024450003.2:340..2577"
                     /db_xref="GeneID:57611"
                     /db_xref="HGNC:HGNC:29286"
                     /db_xref="MIM:614179"
ORIGIN      
        1 mfplralwlv wallgvagsc pepcacvdky ahqfadcayk elrevpeglp anvttlslsa
       61 nkitvlrrga fadvtqvtsl wlahnevrtv epgalavlsq lknldlshnf issfpwsdlr
      121 nlsalqllkm nhnrlgslpr dalgalpdlr slrinnnrlr tlapgtfdal salshlqlyh
      181 npfhcgcglv wlqawaastr vslpepdsia casppalqgv pvyrlpalpc appsvhlsae
      241 ppleapgtpl raglafvlhc iadghptprl qwqlqipggt vvleppvlsg eddgvgaeeg
      301 egegdgdllt qtqaqtptpa pawpappatp rflalangsl lvpllsakea gvytcrahne
      361 lganstsirv avaatgppkh apgaggepdg qaptserkst akgrgnsvlp skpegkikgq
      421 glakvsilge tetepeedts egeeaedqil adpaeeqrcg ngdpsryvsn hafnqsaelk
      481 phvfelgvia ldvaerearv qltplaarwg pgpggaggap rpgrrplrll ylcpagggaa
      541 vqwsrveegv naywfrglrp gtnysvclal ageachvqvv fstkkelpsl lvivavsvfl
      601 lvlatvpllg aacchllakh pgkpyrlilr pqapdpmekr iaadfdpras yleseksypa
      661 ggeaggeepe dvqgeglded aeqgdpsgdl qreeslaacs lvesqskanq eefeagseys
      721 drlplgaeav niaqeingny rqtag
//
LOCUS       XP_047288861             745 aa            linear   PRI 05-AUG-2025
DEFINITION  immunoglobulin superfamily containing leucine-rich repeat protein 2
            isoform X1 [Homo sapiens].
ACCESSION   XP_047288861
VERSION     XP_047288861.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432905.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..745
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..745
                     /product="immunoglobulin superfamily containing
                     leucine-rich repeat protein 2 isoform X1"
                     /calculated_mol_wt=78859
     Region          36..52
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          <51..>183
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          53..76
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          77..100
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          101..124
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          125..148
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          149..172
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          154..>228
                     /region_name="PCC"
                     /note="polycystin cation channel protein; TIGR00864"
                     /db_xref="CDD:188093"
     Region          232..359
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     CDS             1..745
                     /gene="ISLR2"
                     /gene_synonym="LINX"
                     /coded_by="XM_047432905.1:289..2526"
                     /db_xref="GeneID:57611"
                     /db_xref="HGNC:HGNC:29286"
                     /db_xref="MIM:614179"
ORIGIN      
        1 mfplralwlv wallgvagsc pepcacvdky ahqfadcayk elrevpeglp anvttlslsa
       61 nkitvlrrga fadvtqvtsl wlahnevrtv epgalavlsq lknldlshnf issfpwsdlr
      121 nlsalqllkm nhnrlgslpr dalgalpdlr slrinnnrlr tlapgtfdal salshlqlyh
      181 npfhcgcglv wlqawaastr vslpepdsia casppalqgv pvyrlpalpc appsvhlsae
      241 ppleapgtpl raglafvlhc iadghptprl qwqlqipggt vvleppvlsg eddgvgaeeg
      301 egegdgdllt qtqaqtptpa pawpappatp rflalangsl lvpllsakea gvytcrahne
      361 lganstsirv avaatgppkh apgaggepdg qaptserkst akgrgnsvlp skpegkikgq
      421 glakvsilge tetepeedts egeeaedqil adpaeeqrcg ngdpsryvsn hafnqsaelk
      481 phvfelgvia ldvaerearv qltplaarwg pgpggaggap rpgrrplrll ylcpagggaa
      541 vqwsrveegv naywfrglrp gtnysvclal ageachvqvv fstkkelpsl lvivavsvfl
      601 lvlatvpllg aacchllakh pgkpyrlilr pqapdpmekr iaadfdpras yleseksypa
      661 ggeaggeepe dvqgeglded aeqgdpsgdl qreeslaacs lvesqskanq eefeagseys
      721 drlplgaeav niaqeingny rqtag
//
LOCUS       XP_024305772             745 aa            linear   PRI 05-AUG-2025
DEFINITION  immunoglobulin superfamily containing leucine-rich repeat protein 2
            isoform X1 [Homo sapiens].
ACCESSION   XP_024305772
VERSION     XP_024305772.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024450004.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..745
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..745
                     /product="immunoglobulin superfamily containing
                     leucine-rich repeat protein 2 isoform X1"
                     /calculated_mol_wt=78859
     Region          36..52
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          <51..>183
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          53..76
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          77..100
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          101..124
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          125..148
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          149..172
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          154..>228
                     /region_name="PCC"
                     /note="polycystin cation channel protein; TIGR00864"
                     /db_xref="CDD:188093"
     Region          232..359
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     CDS             1..745
                     /gene="ISLR2"
                     /gene_synonym="LINX"
                     /coded_by="XM_024450004.2:335..2572"
                     /db_xref="GeneID:57611"
                     /db_xref="HGNC:HGNC:29286"
                     /db_xref="MIM:614179"
ORIGIN      
        1 mfplralwlv wallgvagsc pepcacvdky ahqfadcayk elrevpeglp anvttlslsa
       61 nkitvlrrga fadvtqvtsl wlahnevrtv epgalavlsq lknldlshnf issfpwsdlr
      121 nlsalqllkm nhnrlgslpr dalgalpdlr slrinnnrlr tlapgtfdal salshlqlyh
      181 npfhcgcglv wlqawaastr vslpepdsia casppalqgv pvyrlpalpc appsvhlsae
      241 ppleapgtpl raglafvlhc iadghptprl qwqlqipggt vvleppvlsg eddgvgaeeg
      301 egegdgdllt qtqaqtptpa pawpappatp rflalangsl lvpllsakea gvytcrahne
      361 lganstsirv avaatgppkh apgaggepdg qaptserkst akgrgnsvlp skpegkikgq
      421 glakvsilge tetepeedts egeeaedqil adpaeeqrcg ngdpsryvsn hafnqsaelk
      481 phvfelgvia ldvaerearv qltplaarwg pgpggaggap rpgrrplrll ylcpagggaa
      541 vqwsrveegv naywfrglrp gtnysvclal ageachvqvv fstkkelpsl lvivavsvfl
      601 lvlatvpllg aacchllakh pgkpyrlilr pqapdpmekr iaadfdpras yleseksypa
      661 ggeaggeepe dvqgeglded aeqgdpsgdl qreeslaacs lvesqskanq eefeagseys
      721 drlplgaeav niaqeingny rqtag
//
LOCUS       XP_024305775             745 aa            linear   PRI 05-AUG-2025
DEFINITION  immunoglobulin superfamily containing leucine-rich repeat protein 2
            isoform X1 [Homo sapiens].
ACCESSION   XP_024305775
VERSION     XP_024305775.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024450007.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..745
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..745
                     /product="immunoglobulin superfamily containing
                     leucine-rich repeat protein 2 isoform X1"
                     /calculated_mol_wt=78859
     Region          36..52
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          <51..>183
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          53..76
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          77..100
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          101..124
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          125..148
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          149..172
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          154..>228
                     /region_name="PCC"
                     /note="polycystin cation channel protein; TIGR00864"
                     /db_xref="CDD:188093"
     Region          232..359
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     CDS             1..745
                     /gene="ISLR2"
                     /gene_synonym="LINX"
                     /coded_by="XM_024450007.2:308..2545"
                     /db_xref="GeneID:57611"
                     /db_xref="HGNC:HGNC:29286"
                     /db_xref="MIM:614179"
ORIGIN      
        1 mfplralwlv wallgvagsc pepcacvdky ahqfadcayk elrevpeglp anvttlslsa
       61 nkitvlrrga fadvtqvtsl wlahnevrtv epgalavlsq lknldlshnf issfpwsdlr
      121 nlsalqllkm nhnrlgslpr dalgalpdlr slrinnnrlr tlapgtfdal salshlqlyh
      181 npfhcgcglv wlqawaastr vslpepdsia casppalqgv pvyrlpalpc appsvhlsae
      241 ppleapgtpl raglafvlhc iadghptprl qwqlqipggt vvleppvlsg eddgvgaeeg
      301 egegdgdllt qtqaqtptpa pawpappatp rflalangsl lvpllsakea gvytcrahne
      361 lganstsirv avaatgppkh apgaggepdg qaptserkst akgrgnsvlp skpegkikgq
      421 glakvsilge tetepeedts egeeaedqil adpaeeqrcg ngdpsryvsn hafnqsaelk
      481 phvfelgvia ldvaerearv qltplaarwg pgpggaggap rpgrrplrll ylcpagggaa
      541 vqwsrveegv naywfrglrp gtnysvclal ageachvqvv fstkkelpsl lvivavsvfl
      601 lvlatvpllg aacchllakh pgkpyrlilr pqapdpmekr iaadfdpras yleseksypa
      661 ggeaggeepe dvqgeglded aeqgdpsgdl qreeslaacs lvesqskanq eefeagseys
      721 drlplgaeav niaqeingny rqtag
//
LOCUS       XP_024305776             745 aa            linear   PRI 05-AUG-2025
DEFINITION  immunoglobulin superfamily containing leucine-rich repeat protein 2
            isoform X1 [Homo sapiens].
ACCESSION   XP_024305776
VERSION     XP_024305776.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024450008.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..745
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..745
                     /product="immunoglobulin superfamily containing
                     leucine-rich repeat protein 2 isoform X1"
                     /calculated_mol_wt=78859
     Region          36..52
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          <51..>183
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          53..76
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          77..100
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          101..124
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          125..148
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          149..172
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          154..>228
                     /region_name="PCC"
                     /note="polycystin cation channel protein; TIGR00864"
                     /db_xref="CDD:188093"
     Region          232..359
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     CDS             1..745
                     /gene="ISLR2"
                     /gene_synonym="LINX"
                     /coded_by="XM_024450008.2:199..2436"
                     /db_xref="GeneID:57611"
                     /db_xref="HGNC:HGNC:29286"
                     /db_xref="MIM:614179"
ORIGIN      
        1 mfplralwlv wallgvagsc pepcacvdky ahqfadcayk elrevpeglp anvttlslsa
       61 nkitvlrrga fadvtqvtsl wlahnevrtv epgalavlsq lknldlshnf issfpwsdlr
      121 nlsalqllkm nhnrlgslpr dalgalpdlr slrinnnrlr tlapgtfdal salshlqlyh
      181 npfhcgcglv wlqawaastr vslpepdsia casppalqgv pvyrlpalpc appsvhlsae
      241 ppleapgtpl raglafvlhc iadghptprl qwqlqipggt vvleppvlsg eddgvgaeeg
      301 egegdgdllt qtqaqtptpa pawpappatp rflalangsl lvpllsakea gvytcrahne
      361 lganstsirv avaatgppkh apgaggepdg qaptserkst akgrgnsvlp skpegkikgq
      421 glakvsilge tetepeedts egeeaedqil adpaeeqrcg ngdpsryvsn hafnqsaelk
      481 phvfelgvia ldvaerearv qltplaarwg pgpggaggap rpgrrplrll ylcpagggaa
      541 vqwsrveegv naywfrglrp gtnysvclal ageachvqvv fstkkelpsl lvivavsvfl
      601 lvlatvpllg aacchllakh pgkpyrlilr pqapdpmekr iaadfdpras yleseksypa
      661 ggeaggeepe dvqgeglded aeqgdpsgdl qreeslaacs lvesqskanq eefeagseys
      721 drlplgaeav niaqeingny rqtag
//
LOCUS       XP_016877935             468 aa            linear   PRI 05-AUG-2025
DEFINITION  immunoglobulin superfamily containing leucine-rich repeat protein 2
            isoform X2 [Homo sapiens].
ACCESSION   XP_016877935
VERSION     XP_016877935.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022446.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..468
                     /product="immunoglobulin superfamily containing
                     leucine-rich repeat protein 2 isoform X2"
                     /calculated_mol_wt=49391
     Region          36..52
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          <51..>183
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          53..76
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          77..100
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          101..124
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          125..148
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          149..172
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          154..>228
                     /region_name="PCC"
                     /note="polycystin cation channel protein; TIGR00864"
                     /db_xref="CDD:188093"
     Region          232..359
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     Region          <350..372
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     CDS             1..468
                     /gene="ISLR2"
                     /gene_synonym="LINX"
                     /coded_by="XM_017022446.3:187..1593"
                     /db_xref="GeneID:57611"
                     /db_xref="HGNC:HGNC:29286"
                     /db_xref="MIM:614179"
ORIGIN      
        1 mfplralwlv wallgvagsc pepcacvdky ahqfadcayk elrevpeglp anvttlslsa
       61 nkitvlrrga fadvtqvtsl wlahnevrtv epgalavlsq lknldlshnf issfpwsdlr
      121 nlsalqllkm nhnrlgslpr dalgalpdlr slrinnnrlr tlapgtfdal salshlqlyh
      181 npfhcgcglv wlqawaastr vslpepdsia casppalqgv pvyrlpalpc appsvhlsae
      241 ppleapgtpl raglafvlhc iadghptprl qwqlqipggt vvleppvlsg eddgvgaeeg
      301 egegdgdllt qtqaqtptpa pawpappatp rflalangsl lvpllsakea gvytcrahne
      361 lganstsirv avaatgppkh apgaggepdg qaptserkst akgrgnsvlp skpegkikgq
      421 glakvsilge tetepeedts egeeaedqil adpaeeqrcg ngdpsrhy
//
LOCUS       XP_011520145             901 aa            linear   PRI 05-AUG-2025
DEFINITION  vacuolar protein sorting-associated protein 18 homolog isoform X1
            [Homo sapiens].
ACCESSION   XP_011520145
VERSION     XP_011520145.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521843.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..901
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..901
                     /product="vacuolar protein sorting-associated protein 18
                     homolog isoform X1"
                     /calculated_mol_wt=102171
     Region          219..362
                     /region_name="Pep3_Vps18"
                     /note="Pep3/Vps18/deep orange family; pfam05131"
                     /db_xref="CDD:461557"
     Region          572..696
                     /region_name="CLH"
                     /note="Clathrin heavy chain repeat homology; smart00299"
                     /db_xref="CDD:128594"
     Region          779..877
                     /region_name="RING-H2_Vps18"
                     /note="RING finger, H2 subclass, found in vacuolar protein
                     sorting-associated protein 18 (Vps18) and similar
                     proteins; cd16689"
                     /db_xref="CDD:438350"
     CDS             1..901
                     /gene="VPS18"
                     /gene_synonym="PEP3"
                     /coded_by="XM_011521843.3:88..2793"
                     /db_xref="GeneID:57617"
                     /db_xref="HGNC:HGNC:15972"
                     /db_xref="MIM:608551"
ORIGIN      
        1 myisgnidlg kanepnhvel grkddakvhk mfldhtgshl lialsstevl yvnrngqkvr
       61 plarwkgqlv esvgwnkalg tesstgpilv gtaqghifea elsasegglf gpapdlyfrp
      121 lyvlneeggp apvcsleaer gpdgrsfvia ttrqrlfqfi graaegaeaq gfsglfaayt
      181 dhpppfrefp snlgyselaf ytpklrsapr afawmmgdgv lygaldcgrp dsllseervw
      241 eypegvgpga spplaivltq fhflllladr veavctltgq vvlrdhflek fgplkhmvkd
      301 sstgqlwayt eravfryhvq reardvwrty ldmnrfdlak eycrerpdcl dtvlareadf
      361 cfrqrryles arcyaltqsy feeialkfle arqeealaef lqrklaslkp aertqatllt
      421 twltelylsr lgalqgdpea ltlyretkec frtflssprh kewlfasras ihellashgd
      481 tehmvyfavi mqdyervvay hcqheayeea lavlarhrdp qlfykfspil irhiprqlvd
      541 awiemgsrld arqlipalvn ysqggevqqv sqairymefc vnvlgeteqa ihnyllslya
      601 rgrpdsllay leqagasphr vhydlkyalr lcaehghhra cvhvykvlel yeeavdlalq
      661 vdvdlakqca dlpeedeelr kklwlkiarh vvqeeedvqt amaclascpl lkiedvlpff
      721 pdfvtidhfk eaicsslkay nhhiqelqre meeatasaqr irrdlqelrg rygtvepqdk
      781 catcdfplln rpfylflcgh mfhadcllqa vrpglpaykq arleelqrkl gaapppakgs
      841 arakeaegga atagpsreql kadldelvaa ecvycgelmi rsidrpfidp qryeeeqlsw
      901 l
//
LOCUS       XP_047288863            1319 aa            linear   PRI 05-AUG-2025
DEFINITION  immunoglobulin superfamily DCC subclass member 4 isoform X1 [Homo
            sapiens].
ACCESSION   XP_047288863
VERSION     XP_047288863.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432907.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1319
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1319
                     /product="immunoglobulin superfamily DCC subclass member 4
                     isoform X1"
                     /calculated_mol_wt=141476
     Region          66..148
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cd00096"
                     /db_xref="CDD:409353"
     Region          66..70
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          82..86
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          104..108
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          131..136
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          145..148
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          158..231
                     /region_name="I-set"
                     /note="Immunoglobulin I-set domain; pfam07679"
                     /db_xref="CDD:400151"
     Region          173..177
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          186..190
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          208..212
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          222..227
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          263..400
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          274..278
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          287..291
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          419..491
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          421..425
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:143205"
     Region          434..438
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:143205"
     Region          457..461
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:143205"
     Region          <471..>677
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     Region          471..476
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:143205"
     Region          484..487
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:143205"
     Site            order(699,778,793)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          701..795
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Region          819..911
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(819,884,899)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Site            order(900..901,903..904)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          919..1011
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(1000..1001,1003..1004)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          <1053..1319
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..1319
                     /gene="IGDCC4"
                     /gene_synonym="DDM36; NOPE"
                     /coded_by="XM_047432907.1:344..4303"
                     /db_xref="GeneID:57722"
                     /db_xref="HGNC:HGNC:13770"
                     /db_xref="MIM:616810"
ORIGIN      
        1 mgrvsprphp pgtdqgsvde vsrassspqp saewvrgell lpqettvels cgvgplqvil
       61 gpeqaavlnc slgaaaagpp trvtwskdgd tllehdhlhl lpngslwlsq plapngsdes
      121 vpeavgvieg nysclahgpl gvlasqtavv klatladfsl hpesqtveen gtarfechie
      181 glpapiitwe kdqvtlpeep rlivlpngvl qildvqesda gpyrcvatns arqhfsqeal
      241 lsvahrgsla strgqdvviv aapenttvvs gqsvvmecva sadptpfvsw vrqdgdsraq
      301 rvparggnei rtrdgcvcfi rvqsvpevrr lkgravpsvp ssaspspspd gkpistdviv
      361 lgrtnllian aqpwhsgvyv crankprtrd fataaaelrv laapaitqap ealsrtrast
      421 arfvcrasge prpalrwlhn gaplrpngrv kvqggggslv itqiglqdag yyqcvaensa
      481 gmacaaasla vvvreglpsa ptrvtatpls ssavlvawer pemhseqiig fslhyqkarg
      541 mdnveyqfav nndttelqvr dlepntdyef yvvaysqlga srtstpalvh tlddvpsaap
      601 qlslsspnps dirvawlplp pslsngqvvk ykieyglgke dqifstevrg netqlmlnsl
      661 qpnkvyrvri sagtaagfga psqwmhhrtp smhnqshvpf apaelkvqak meslvvswqp
      721 pphptqisgy klywrevgae eeangdrlpg grgdqawdvg pvrlkkkvkq yeltqlvpgr
      781 lyevklvafn khedgyaavw kgktekapap dmpiqrgppl ppahvhaesn sstsiwlrwk
      841 kpdfttvkiv nytvrfspwg lrnaslvtyy tssgedilig glkpftkyef avqshgvdmd
      901 gpfgsvvers tlpdrpstpp sdlrlspltp stvrlhwcpp tepngeivey lilyssnhtq
      961 pehqwtlltt qgnifsaevh glesdtryff kmgartevgp gpfsrlqdvi tlqeklsdsl
     1021 dmhsvtgiiv gvclgllcll acmcaglrrs phreslpgls statpgnpal ysrarlgpps
     1081 ppaahelesl vhphpqdwsp ppsdvedrae vhslmgggvs egrshskrki swaqpsglsw
     1141 agswagcelp qagprpaltr allppagtgq tlllqalvyd aikgngrkks ppacrnqvea
     1201 evivhsdfsa sngnpdlhlq dlepedplpp eapdlisgvg dpgqgaawld relggcelaa
     1261 pgpdrltclp eaasascsyp dlqpgevlee tpgdscqlks pcplgaspgl prspvsssa
//
LOCUS       XP_047288864            1306 aa            linear   PRI 05-AUG-2025
DEFINITION  immunoglobulin superfamily DCC subclass member 4 isoform X2 [Homo
            sapiens].
ACCESSION   XP_047288864
VERSION     XP_047288864.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432908.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1306
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1306
                     /product="immunoglobulin superfamily DCC subclass member 4
                     isoform X2"
                     /calculated_mol_wt=140021
     Region          53..135
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cd00096"
                     /db_xref="CDD:409353"
     Region          53..57
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          69..73
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          91..95
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          118..123
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          132..135
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          145..218
                     /region_name="I-set"
                     /note="Immunoglobulin I-set domain; pfam07679"
                     /db_xref="CDD:400151"
     Region          160..164
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          173..177
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          195..199
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          209..214
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          250..387
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          261..265
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          274..278
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          406..478
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          408..412
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:143205"
     Region          421..425
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:143205"
     Region          444..448
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:143205"
     Region          <458..>664
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     Region          458..463
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:143205"
     Region          471..474
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:143205"
     Site            order(686,765,780)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          688..782
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Region          806..898
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(806,871,886)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Site            order(887..888,890..891)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          906..998
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(987..988,990..991)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          <1040..1306
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..1306
                     /gene="IGDCC4"
                     /gene_synonym="DDM36; NOPE"
                     /coded_by="XM_047432908.1:86..4006"
                     /db_xref="GeneID:57722"
                     /db_xref="HGNC:HGNC:13770"
                     /db_xref="MIM:616810"
ORIGIN      
        1 margdagrgr gllaltfcll aargelllpq ettvelscgv gplqvilgpe qaavlncslg
       61 aaaagpptrv twskdgdtll ehdhlhllpn gslwlsqpla pngsdesvpe avgviegnys
      121 clahgplgvl asqtavvkla tladfslhpe sqtveengta rfechieglp apiitwekdq
      181 vtlpeeprli vlpngvlqil dvqesdagpy rcvatnsarq hfsqeallsv ahrgslastr
      241 gqdvvivaap enttvvsgqs vvmecvasad ptpfvswvrq dgdsraqrvp arggneirtr
      301 dgcvcfirvq svpevrrlkg ravpsvpssa spspspdgkp istdvivlgr tnllianaqp
      361 whsgvyvcra nkprtrdfat aaaelrvlaa paitqapeal srtrastarf vcrasgeprp
      421 alrwlhngap lrpngrvkvq ggggslvitq iglqdagyyq cvaensagma caaaslavvv
      481 reglpsaptr vtatplsssa vlvawerpem hseqiigfsl hyqkargmdn veyqfavnnd
      541 ttelqvrdle pntdyefyvv aysqlgasrt stpalvhtld dvpsaapqls lsspnpsdir
      601 vawlplppsl sngqvvkyki eyglgkedqi fstevrgnet qlmlnslqpn kvyrvrisag
      661 taagfgapsq wmhhrtpsmh nqshvpfapa elkvqakmes lvvswqppph ptqisgykly
      721 wrevgaeeea ngdrlpggrg dqawdvgpvr lkkkvkqyel tqlvpgrlye vklvafnkhe
      781 dgyaavwkgk tekapapdmp iqrgpplppa hvhaesnsst siwlrwkkpd fttvkivnyt
      841 vrfspwglrn aslvtyytss gediligglk pftkyefavq shgvdmdgpf gsvverstlp
      901 drpstppsdl rlspltpstv rlhwcpptep ngeiveylil yssnhtqpeh qwtllttqgn
      961 ifsaevhgle sdtryffkmg artevgpgpf srlqdvitlq eklsdsldmh svtgiivgvc
     1021 lgllcllacm caglrrsphr eslpglssta tpgnpalysr arlgppsppa aheleslvhp
     1081 hpqdwsppps dvedraevhs lmgggvsegr shskrkiswa qpsglswags wagcelpqag
     1141 prpaltrall ppagtgqtll lqalvydaik gngrkksppa crnqveaevi vhsdfsasng
     1201 npdlhlqdle pedplppeap dlisgvgdpg qgaawldrel ggcelaapgp drltclpeaa
     1261 sascsypdlq pgevleetpg dscqlkspcp lgaspglprs pvsssa
//
LOCUS       XP_016877937            1264 aa            linear   PRI 05-AUG-2025
DEFINITION  immunoglobulin superfamily DCC subclass member 4 isoform X3 [Homo
            sapiens].
ACCESSION   XP_016877937
VERSION     XP_016877937.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022448.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1264
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1264
                     /product="immunoglobulin superfamily DCC subclass member 4
                     isoform X3"
                     /calculated_mol_wt=135622
     Region          66..148
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cd00096"
                     /db_xref="CDD:409353"
     Region          66..70
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          82..86
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          104..108
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          131..136
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          145..148
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          158..231
                     /region_name="I-set"
                     /note="Immunoglobulin I-set domain; pfam07679"
                     /db_xref="CDD:400151"
     Region          173..177
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          186..190
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          208..212
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          222..227
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          263..344
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          274..278
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          287..292
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          308..312
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          322..327
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          337..340
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          363..435
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          365..369
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:143205"
     Region          378..382
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:143205"
     Region          401..405
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:143205"
     Region          415..420
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:143205"
     Region          428..431
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:143205"
     Site            order(442,508,523)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          443..528
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Region          <490..819
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     Site            order(524..525,527..528)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          864..956
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(945..946,948..949)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          <998..1264
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..1264
                     /gene="IGDCC4"
                     /gene_synonym="DDM36; NOPE"
                     /coded_by="XM_017022448.3:342..4136"
                     /db_xref="GeneID:57722"
                     /db_xref="HGNC:HGNC:13770"
                     /db_xref="MIM:616810"
ORIGIN      
        1 mgrvsprphp pgtdqgsvde vsrassspqp saewvrgell lpqettvels cgvgplqvil
       61 gpeqaavlnc slgaaaagpp trvtwskdgd tllehdhlhl lpngslwlsq plapngsdes
      121 vpeavgvieg nysclahgpl gvlasqtavv klatladfsl hpesqtveen gtarfechie
      181 glpapiitwe kdqvtlpeep rlivlpngvl qildvqesda gpyrcvatns arqhfsqeal
      241 lsvahrgsla strgqdvviv aapenttvvs gqsvvmecva sadptpfvsw vrqdgkpist
      301 dvivlgrtnl lianaqpwhs gvyvcrankp rtrdfataaa elrvlaapai tqapealsrt
      361 rastarfvcr asgeprpalr wlhngaplrp ngrvkvqggg gslvitqigl qdagyyqcva
      421 ensagmacaa aslavvvreg lpsaptrvta tplsssavlv awerpemhse qiigfslhyq
      481 kargmdnvey qfavnndtte lqvrdlepnt dyefyvvays qlgasrtstp alvhtlddvp
      541 saapqlslss pnpsdirvaw lplppslsng qvvkykieyg lgkedqifst evrgnetqlm
      601 lnslqpnkvy rvrisagtaa gfgapsqwmh hrtpsmhnqs hvpfapaelk vqakmeslvv
      661 swqppphptq isgyklywre vgaeeeangd rlpggrgdqa wdvgpvrlkk kvkqyeltql
      721 vpgrlyevkl vafnkhedgy aavwkgktek apapdmpiqr gpplppahvh aesnsstsiw
      781 lrwkkpdftt vkivnytvrf spwglrnasl vtyytsssge diligglkpf tkyefavqsh
      841 gvdmdgpfgs vverstlpdr pstppsdlrl spltpstvrl hwcpptepng eiveylilys
      901 snhtqpehqw tllttqgnif saevhglesd tryffkmgar tevgpgpfsr lqdvitlqek
      961 lsdsldmhsv tgiivgvclg llcllacmca glrrsphres lpglsstatp gnpalysrar
     1021 lgppsppaah eleslvhphp qdwspppsdv edraevhslm gggvsegrsh skrkiswaqp
     1081 sglswagswa gcelpqagpr paltrallpp agtgqtlllq alvydaikgn grkksppacr
     1141 nqveaevivh sdfsasngnp dlhlqdlepe dplppeapdl isgvgdpgqg aawldrelgg
     1201 celaapgpdr ltclpeaasa scsypdlqpg evleetpgds cqlkspcplg aspglprspv
     1261 sssa
//
LOCUS       XP_011520147            1263 aa            linear   PRI 05-AUG-2025
DEFINITION  immunoglobulin superfamily DCC subclass member 4 isoform X4 [Homo
            sapiens].
ACCESSION   XP_011520147
VERSION     XP_011520147.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521845.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1263
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1263
                     /product="immunoglobulin superfamily DCC subclass member 4
                     isoform X4"
                     /calculated_mol_wt=135535
     Region          66..148
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cd00096"
                     /db_xref="CDD:409353"
     Region          66..70
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          82..86
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          104..108
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          131..136
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          145..148
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          158..231
                     /region_name="I-set"
                     /note="Immunoglobulin I-set domain; pfam07679"
                     /db_xref="CDD:400151"
     Region          173..177
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          186..190
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          208..212
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          222..227
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          263..344
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          274..278
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          287..292
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          308..312
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          322..327
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          337..340
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          363..435
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          365..369
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          378..382
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          401..405
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          415..420
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          428..431
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Site            order(442,508,523)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          443..528
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Region          <490..825
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     Site            order(524..525,527..528)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          863..955
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(944..945,947..948)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          <997..1263
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..1263
                     /gene="IGDCC4"
                     /gene_synonym="DDM36; NOPE"
                     /coded_by="XM_011521845.4:340..4131"
                     /db_xref="GeneID:57722"
                     /db_xref="HGNC:HGNC:13770"
                     /db_xref="MIM:616810"
ORIGIN      
        1 mgrvsprphp pgtdqgsvde vsrassspqp saewvrgell lpqettvels cgvgplqvil
       61 gpeqaavlnc slgaaaagpp trvtwskdgd tllehdhlhl lpngslwlsq plapngsdes
      121 vpeavgvieg nysclahgpl gvlasqtavv klatladfsl hpesqtveen gtarfechie
      181 glpapiitwe kdqvtlpeep rlivlpngvl qildvqesda gpyrcvatns arqhfsqeal
      241 lsvahrgsla strgqdvviv aapenttvvs gqsvvmecva sadptpfvsw vrqdgkpist
      301 dvivlgrtnl lianaqpwhs gvyvcrankp rtrdfataaa elrvlaapai tqapealsrt
      361 rastarfvcr asgeprpalr wlhngaplrp ngrvkvqggg gslvitqigl qdagyyqcva
      421 ensagmacaa aslavvvreg lpsaptrvta tplsssavlv awerpemhse qiigfslhyq
      481 kargmdnvey qfavnndtte lqvrdlepnt dyefyvvays qlgasrtstp alvhtlddvp
      541 saapqlslss pnpsdirvaw lplppslsng qvvkykieyg lgkedqifst evrgnetqlm
      601 lnslqpnkvy rvrisagtaa gfgapsqwmh hrtpsmhnqs hvpfapaelk vqakmeslvv
      661 swqppphptq isgyklywre vgaeeeangd rlpggrgdqa wdvgpvrlkk kvkqyeltql
      721 vpgrlyevkl vafnkhedgy aavwkgktek apapdmpiqr gpplppahvh aesnsstsiw
      781 lrwkkpdftt vkivnytvrf spwglrnasl vtyytssged iligglkpft kyefavqshg
      841 vdmdgpfgsv verstlpdrp stppsdlrls pltpstvrlh wcpptepnge iveylilyss
      901 nhtqpehqwt llttqgnifs aevhglesdt ryffkmgart evgpgpfsrl qdvitlqekl
      961 sdsldmhsvt giivgvclgl lcllacmcag lrrsphresl pglsstatpg npalysrarl
     1021 gppsppaahe leslvhphpq dwspppsdve draevhslmg ggvsegrshs krkiswaqps
     1081 glswagswag celpqagprp altrallppa gtgqtlllqa lvydaikgng rkksppacrn
     1141 qveaevivhs dfsasngnpd lhlqdleped plppeapdli sgvgdpgqga awldrelggc
     1201 elaapgpdrl tclpeaasas csypdlqpge vleetpgdsc qlkspcplga spglprspvs
     1261 ssa
//
LOCUS       XP_011520148            1251 aa            linear   PRI 05-AUG-2025
DEFINITION  immunoglobulin superfamily DCC subclass member 4 isoform X5 [Homo
            sapiens].
ACCESSION   XP_011520148
VERSION     XP_011520148.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521846.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1251
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1251
                     /product="immunoglobulin superfamily DCC subclass member 4
                     isoform X5"
                     /calculated_mol_wt=134166
     Region          53..135
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cd00096"
                     /db_xref="CDD:409353"
     Region          53..57
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          69..73
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          91..95
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          118..123
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          132..135
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          145..218
                     /region_name="I-set"
                     /note="Immunoglobulin I-set domain; pfam07679"
                     /db_xref="CDD:400151"
     Region          160..164
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          173..177
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          195..199
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          209..214
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          250..331
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          261..265
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          274..279
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          295..299
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          309..314
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          324..327
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          350..422
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          352..356
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          365..369
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          388..392
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          402..407
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          415..418
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Site            order(429,495,510)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          430..515
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Region          <477..806
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     Site            order(511..512,514..515)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          851..943
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(932..933,935..936)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          <985..1251
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..1251
                     /gene="IGDCC4"
                     /gene_synonym="DDM36; NOPE"
                     /coded_by="XM_011521846.4:86..3841"
                     /db_xref="GeneID:57722"
                     /db_xref="HGNC:HGNC:13770"
                     /db_xref="MIM:616810"
ORIGIN      
        1 margdagrgr gllaltfcll aargelllpq ettvelscgv gplqvilgpe qaavlncslg
       61 aaaagpptrv twskdgdtll ehdhlhllpn gslwlsqpla pngsdesvpe avgviegnys
      121 clahgplgvl asqtavvkla tladfslhpe sqtveengta rfechieglp apiitwekdq
      181 vtlpeeprli vlpngvlqil dvqesdagpy rcvatnsarq hfsqeallsv ahrgslastr
      241 gqdvvivaap enttvvsgqs vvmecvasad ptpfvswvrq dgkpistdvi vlgrtnllia
      301 naqpwhsgvy vcrankprtr dfataaaelr vlaapaitqa pealsrtras tarfvcrasg
      361 eprpalrwlh ngaplrpngr vkvqggggsl vitqiglqda gyyqcvaens agmacaaasl
      421 avvvreglps aptrvtatpl sssavlvawe rpemhseqii gfslhyqkar gmdnveyqfa
      481 vnndttelqv rdlepntdye fyvvaysqlg asrtstpalv htlddvpsaa pqlslsspnp
      541 sdirvawlpl ppslsngqvv kykieyglgk edqifstevr gnetqlmlns lqpnkvyrvr
      601 isagtaagfg apsqwmhhrt psmhnqshvp fapaelkvqa kmeslvvswq ppphptqisg
      661 yklywrevga eeeangdrlp ggrgdqawdv gpvrlkkkvk qyeltqlvpg rlyevklvaf
      721 nkhedgyaav wkgktekapa pdmpiqrgpp lppahvhaes nsstsiwlrw kkpdfttvki
      781 vnytvrfspw glrnaslvty ytsssgedil igglkpftky efavqshgvd mdgpfgsvve
      841 rstlpdrpst ppsdlrlspl tpstvrlhwc pptepngeiv eylilyssnh tqpehqwtll
      901 ttqgnifsae vhglesdtry ffkmgartev gpgpfsrlqd vitlqeklsd sldmhsvtgi
      961 ivgvclgllc llacmcaglr rsphreslpg lsstatpgnp alysrarlgp psppaahele
     1021 slvhphpqdw spppsdvedr aevhslmggg vsegrshskr kiswaqpsgl swagswagce
     1081 lpqagprpal trallppagt gqtlllqalv ydaikgngrk ksppacrnqv eaevivhsdf
     1141 sasngnpdlh lqdlepedpl ppeapdlisg vgdpgqgaaw ldrelggcel aapgpdrltc
     1201 lpeaasascs ypdlqpgevl eetpgdscql kspcplgasp glprspvsss a
//
LOCUS       XP_016877938             664 aa            linear   PRI 05-AUG-2025
DEFINITION  immunoglobulin superfamily DCC subclass member 4 isoform X6 [Homo
            sapiens].
ACCESSION   XP_016877938
VERSION     XP_016877938.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022449.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..664
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..664
                     /product="immunoglobulin superfamily DCC subclass member 4
                     isoform X6"
                     /calculated_mol_wt=71129
     Region          66..148
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cd00096"
                     /db_xref="CDD:409353"
     Region          66..70
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          82..86
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          104..108
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          131..136
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          145..148
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          158..231
                     /region_name="I-set"
                     /note="Immunoglobulin I-set domain; pfam07679"
                     /db_xref="CDD:400151"
     Region          173..177
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          186..190
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          208..212
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          222..227
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          263..344
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          274..278
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          287..292
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          308..312
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          322..327
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          337..340
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          363..435
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          365..369
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:143205"
     Region          378..382
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:143205"
     Region          401..405
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:143205"
     Region          415..420
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:143205"
     Region          428..431
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:143205"
     Site            order(442,508,523)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          443..528
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(524..525,527..528)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          540..633
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(540,606,621)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Site            order(622..623,625..626)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     CDS             1..664
                     /gene="IGDCC4"
                     /gene_synonym="DDM36; NOPE"
                     /coded_by="XM_017022449.2:349..2343"
                     /db_xref="GeneID:57722"
                     /db_xref="HGNC:HGNC:13770"
                     /db_xref="MIM:616810"
ORIGIN      
        1 mgrvsprphp pgtdqgsvde vsrassspqp saewvrgell lpqettvels cgvgplqvil
       61 gpeqaavlnc slgaaaagpp trvtwskdgd tllehdhlhl lpngslwlsq plapngsdes
      121 vpeavgvieg nysclahgpl gvlasqtavv klatladfsl hpesqtveen gtarfechie
      181 glpapiitwe kdqvtlpeep rlivlpngvl qildvqesda gpyrcvatns arqhfsqeal
      241 lsvahrgsla strgqdvviv aapenttvvs gqsvvmecva sadptpfvsw vrqdgkpist
      301 dvivlgrtnl lianaqpwhs gvyvcrankp rtrdfataaa elrvlaapai tqapealsrt
      361 rastarfvcr asgeprpalr wlhngaplrp ngrvkvqggg gslvitqigl qdagyyqcva
      421 ensagmacaa aslavvvreg lpsaptrvta tplsssavlv awerpemhse qiigfslhyq
      481 kargmdnvey qfavnndtte lqvrdlepnt dyefyvvays qlgasrtstp alvhtlddvp
      541 saapqlslss pnpsdirvaw lplppslsng qvvkykieyg lgkedqifst evrgnetqlm
      601 lnslqpnkvy rvrisagtaa gfgapsqwmh hrtpsmhnqs haasrmmvmm ivfverpnrr
      661 vikc
//
LOCUS       XP_047288867             507 aa            linear   PRI 05-AUG-2025
DEFINITION  BBSome complex member BBS4 isoform X1 [Homo sapiens].
ACCESSION   XP_047288867
VERSION     XP_047288867.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432911.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 21% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..507
                     /product="BBSome complex member BBS4 isoform X1"
                     /calculated_mol_wt=56865
     Region          24..49
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          56..83
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          59..320
                     /region_name="LapB"
                     /note="Lipopolysaccharide biosynthesis regulator
                     YciM/LapB, contains six TPR domains and a C-terminal
                     metal-binding domain [Cell wall/membrane/envelope
                     biogenesis]; COG2956"
                     /db_xref="CDD:442196"
     Region          89..117
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(90,93..94,97..98,100,124,127..128,131..132,134..135,
                     160..161,164..165,168)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          122..152
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          157..184
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          190..217
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          224..252
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          238..>434
                     /region_name="Spy"
                     /note="Predicted O-linked N-acetylglucosamine transferase,
                     SPINDLY family [Posttranslational modification, protein
                     turnover, chaperones]; COG3914"
                     /db_xref="CDD:443119"
     Region          258..286
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(259,262..263,266..267,269,293,296..297,300..301,
                     303..304,327,330..331,334..335,338)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          291..321
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          326..353
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          360..385
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..507
                     /gene="BBS4"
                     /coded_by="XM_047432911.1:429..1952"
                     /db_xref="GeneID:585"
                     /db_xref="HGNC:HGNC:969"
                     /db_xref="MIM:600374"
ORIGIN      
        1 miwntrnsty iftapefpil ekqnwlihlh yirkdyeack avikeqlqet qglceyaiyv
       61 qalifrlegn iqeslelfqt cavlspqsad nlkqvarslf llgkhkaaie vyneaaklnq
      121 kdweishnlg vcyiylkqfn kaqdqlhnal nlnrhdltyi mlgkihlleg dldkaievyk
      181 kavefspent ellttlglly lqlgiyqkaf ehlgnaltyd ptnykailaa gsmmqthgdf
      241 dvaltkyrvv acavpesppl wnnigmcffg kkkyvaaisc lkranylapf dwkilynlgl
      301 vhltmqqyas afhflsaain fqpkmgelym llavaltnle dienakraya eavhldkcnp
      361 lvnlnyavll ynqgekknal aqyqemekkv sllkdnssle fdsemvemaq klgaalqvge
      421 alvwtkpvkd pkskhqttst skpasfqqpl gsnqalgqam ssaaayrtlp sgaggtsqft
      481 kppslplepe pavessptet seqirek
//
LOCUS       XP_016877939             504 aa            linear   PRI 05-AUG-2025
DEFINITION  BBSome complex member BBS4 isoform X2 [Homo sapiens].
ACCESSION   XP_016877939
VERSION     XP_016877939.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022450.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..504
                     /product="BBSome complex member BBS4 isoform X2"
                     /calculated_mol_wt=56314
     Region          34..173
                     /region_name="TadD"
                     /note="Flp pilus assembly protein TadD, contains TPR
                     repeats [Intracellular trafficking, secretion, and
                     vesicular transport, Extracellular structures]; COG5010"
                     /db_xref="CDD:444034"
     Region          44..69
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          76..103
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          109..137
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(110,113..114,117..118,120,144,147..148,151..152,
                     154..155,180..181,184..185,188)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          114..383
                     /region_name="LapB"
                     /note="Lipopolysaccharide biosynthesis regulator
                     YciM/LapB, contains six TPR domains and a C-terminal
                     metal-binding domain [Cell wall/membrane/envelope
                     biogenesis]; COG2956"
                     /db_xref="CDD:442196"
     Region          142..172
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          177..204
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          222..249
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          255..283
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(256,259..260,263..264,266,290,293..294,297..298,
                     300..301,324,327..328,331..332,335)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          288..318
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          323..350
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          357..382
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..504
                     /gene="BBS4"
                     /coded_by="XM_017022450.2:311..1825"
                     /db_xref="GeneID:585"
                     /db_xref="HGNC:HGNC:969"
                     /db_xref="MIM:600374"
ORIGIN      
        1 maltvvpsfs vsgvwkrtqf pvstesqkpr qkkapefpil ekqnwlihlh yirkdyeack
       61 avikeqlqet qglceyaiyv qalifrlegn iqeslelfqt cavlspqsad nlkqvarslf
      121 llgkhkaaie vyneaaklnq kdweishnlg vcyiylkqfn kaqdqlhnal nlnrhdltyi
      181 mlgkihlleg dldkaievyk kavefspent ellttlglly lqailaagsm mqthgdfdva
      241 ltkyrvvaca vpespplwnn igmcffgkkk yvaaisclkr anylapfdwk ilynlglvhl
      301 tmqqyasafh flsaainfqp kmgelymlla valtnledie nakrayaeav hldkcnplvn
      361 lnyavllynq gekknalaqy qemekkvsll kdnsslefds emvemaqklg aalqvgealv
      421 wtkpvkdpks khqttstskp asfqqplgsn qalgqamssa aayrtlpsga ggtsqftkpp
      481 slplepepav essptetseq irek
//
LOCUS       XP_047288868             347 aa            linear   PRI 05-AUG-2025
DEFINITION  BBSome complex member BBS4 isoform X3 [Homo sapiens].
ACCESSION   XP_047288868
VERSION     XP_047288868.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432912.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..347
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..347
                     /product="BBSome complex member BBS4 isoform X3"
                     /calculated_mol_wt=38151
     Region          1..258
                     /region_name="LapB"
                     /note="Lipopolysaccharide biosynthesis regulator
                     YciM/LapB, contains six TPR domains and a C-terminal
                     metal-binding domain [Cell wall/membrane/envelope
                     biogenesis]; COG2956"
                     /db_xref="CDD:442196"
     Region          64..92
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          98..126
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(99,102..103,106..107,109,133,136..137,140..141,
                     143..144,167,170..171,174..175,178)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          131..161
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          166..193
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          200..225
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..347
                     /gene="BBS4"
                     /coded_by="XM_047432912.1:486..1529"
                     /db_xref="GeneID:585"
                     /db_xref="HGNC:HGNC:969"
                     /db_xref="MIM:600374"
ORIGIN      
        1 mlgkihlleg dldkaievyk kavefspent ellttlglly lqlgiyqkaf ehlgnaltyd
       61 ptnykailaa gsmmqthgdf dvaltkyrvv acavpesppl wnnigmcffg kkkyvaaisc
      121 lkranylapf dwkilynlgl vhltmqqyas afhflsaain fqpkmgelym llavaltnle
      181 dienakraya eavhldkcnp lvnlnyavll ynqgekknal aqyqemekkv sllkdnssle
      241 fdsemvemaq klgaalqvge alvwtkpvkd pkskhqttst skpasfqqpl gsnqalgqam
      301 ssaaayrtlp sgaggtsqft kppslplepe pavessptet seqirek
//
LOCUS       XP_047288869             347 aa            linear   PRI 05-AUG-2025
DEFINITION  BBSome complex member BBS4 isoform X3 [Homo sapiens].
ACCESSION   XP_047288869
VERSION     XP_047288869.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432913.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..347
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..347
                     /product="BBSome complex member BBS4 isoform X3"
                     /calculated_mol_wt=38151
     Region          1..258
                     /region_name="LapB"
                     /note="Lipopolysaccharide biosynthesis regulator
                     YciM/LapB, contains six TPR domains and a C-terminal
                     metal-binding domain [Cell wall/membrane/envelope
                     biogenesis]; COG2956"
                     /db_xref="CDD:442196"
     Region          64..92
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          98..126
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(99,102..103,106..107,109,133,136..137,140..141,
                     143..144,167,170..171,174..175,178)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          131..161
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          166..193
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          200..225
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..347
                     /gene="BBS4"
                     /coded_by="XM_047432913.1:374..1417"
                     /db_xref="GeneID:585"
                     /db_xref="HGNC:HGNC:969"
                     /db_xref="MIM:600374"
ORIGIN      
        1 mlgkihlleg dldkaievyk kavefspent ellttlglly lqlgiyqkaf ehlgnaltyd
       61 ptnykailaa gsmmqthgdf dvaltkyrvv acavpesppl wnnigmcffg kkkyvaaisc
      121 lkranylapf dwkilynlgl vhltmqqyas afhflsaain fqpkmgelym llavaltnle
      181 dienakraya eavhldkcnp lvnlnyavll ynqgekknal aqyqemekkv sllkdnssle
      241 fdsemvemaq klgaalqvge alvwtkpvkd pkskhqttst skpasfqqpl gsnqalgqam
      301 ssaaayrtlp sgaggtsqft kppslplepe pavessptet seqirek
//
LOCUS       XP_016877943             347 aa            linear   PRI 05-AUG-2025
DEFINITION  BBSome complex member BBS4 isoform X3 [Homo sapiens].
ACCESSION   XP_016877943
VERSION     XP_016877943.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022454.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..347
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..347
                     /product="BBSome complex member BBS4 isoform X3"
                     /calculated_mol_wt=38151
     Region          1..258
                     /region_name="LapB"
                     /note="Lipopolysaccharide biosynthesis regulator
                     YciM/LapB, contains six TPR domains and a C-terminal
                     metal-binding domain [Cell wall/membrane/envelope
                     biogenesis]; COG2956"
                     /db_xref="CDD:442196"
     Region          64..92
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          98..126
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(99,102..103,106..107,109,133,136..137,140..141,
                     143..144,167,170..171,174..175,178)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          131..161
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          166..193
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          200..225
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..347
                     /gene="BBS4"
                     /coded_by="XM_017022454.2:379..1422"
                     /db_xref="GeneID:585"
                     /db_xref="HGNC:HGNC:969"
                     /db_xref="MIM:600374"
ORIGIN      
        1 mlgkihlleg dldkaievyk kavefspent ellttlglly lqlgiyqkaf ehlgnaltyd
       61 ptnykailaa gsmmqthgdf dvaltkyrvv acavpesppl wnnigmcffg kkkyvaaisc
      121 lkranylapf dwkilynlgl vhltmqqyas afhflsaain fqpkmgelym llavaltnle
      181 dienakraya eavhldkcnp lvnlnyavll ynqgekknal aqyqemekkv sllkdnssle
      241 fdsemvemaq klgaalqvge alvwtkpvkd pkskhqttst skpasfqqpl gsnqalgqam
      301 ssaaayrtlp sgaggtsqft kppslplepe pavessptet seqirek
//
LOCUS       XP_047288870             275 aa            linear   PRI 05-AUG-2025
DEFINITION  BBSome complex member BBS4 isoform X4 [Homo sapiens].
ACCESSION   XP_047288870
VERSION     XP_047288870.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432914.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..275
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..275
                     /product="BBSome complex member BBS4 isoform X4"
                     /calculated_mol_wt=30199
     Region          6..>153
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          26..54
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(27,30..31,34..35,37,61,64..65,68..69,71..72,95,
                     98..99,102..103,106)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          59..89
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          94..121
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          128..153
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..275
                     /gene="BBS4"
                     /coded_by="XM_047432914.1:100..927"
                     /db_xref="GeneID:585"
                     /db_xref="HGNC:HGNC:969"
                     /db_xref="MIM:600374"
ORIGIN      
        1 mmqthgdfdv altkyrvvac avpespplwn nigmcffgkk kyvaaisclk ranylapfdw
       61 kilynlglvh ltmqqyasaf hflsaainfq pkmgelymll avaltnledi enakrayaea
      121 vhldkcnplv nlnyavllyn qgekknalaq yqemekkvsl lkdnsslefd semvemaqkl
      181 gaalqvgeal vwtkpvkdpk skhqttstsk pasfqqplgs nqalgqamss aaayrtlpsg
      241 aggtsqftkp pslplepepa vessptetse qirek
//
LOCUS       XP_047288874             221 aa            linear   PRI 05-AUG-2025
DEFINITION  ras-related protein Rab-27A isoform X1 [Homo sapiens].
ACCESSION   XP_047288874
VERSION     XP_047288874.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432918.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..221
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..221
                     /product="ras-related protein Rab-27A isoform X1"
                     /calculated_mol_wt=24737
     Region          6..185
                     /region_name="Rab27A"
                     /note="Rab GTPase family 27a (Rab27a); cd04127"
                     /db_xref="CDD:206700"
     Site            6..11
                     /site_type="other"
                     /note="Rab subfamily motif 1 (RabSF1)"
                     /db_xref="CDD:206700"
     Site            16..23
                     /site_type="other"
                     /note="G1 box"
                     /db_xref="CDD:206700"
     Site            order(19..24,134,136,164..165)
                     /site_type="other"
                     /note="GTP/Mg2+ binding site [chemical binding]"
                     /db_xref="CDD:206700"
     Site            order(24..34,39..40)
                     /site_type="other"
                     /note="Rab subfamily motif 2 (RabSF2)"
                     /db_xref="CDD:206700"
     Site            order(34,39..47)
                     /site_type="other"
                     /note="Switch I region"
                     /db_xref="CDD:206700"
     Site            order(39,43..50,67,69)
                     /site_type="other"
                     /note="putative GEF interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:206700"
     Site            41
                     /site_type="other"
                     /note="G2 box"
                     /db_xref="CDD:206700"
     Site            order(42,44..46,71,73,80..81,84,88,90..93)
                     /site_type="active"
                     /note="putative effector interaction site [active]"
                     /db_xref="CDD:206700"
     Site            order(42..43,45,73..74,81,83,85..87)
                     /site_type="other"
                     /note="putative GDI interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:206700"
     Site            42..46
                     /site_type="other"
                     /note="Rab family motif 1 (RabF1)"
                     /db_xref="CDD:206700"
     Site            69..73
                     /site_type="other"
                     /note="Rab family motif 2 (RabF2)"
                     /db_xref="CDD:206700"
     Site            74..77
                     /site_type="other"
                     /note="G3 box"
                     /db_xref="CDD:206700"
     Site            order(77,79..89)
                     /site_type="other"
                     /note="Switch II region"
                     /db_xref="CDD:206700"
     Site            80..85
                     /site_type="other"
                     /note="Rab family motif 3 (RabF3)"
                     /db_xref="CDD:206700"
     Site            88..92
                     /site_type="other"
                     /note="Rab family motif 4 (RabF4)"
                     /db_xref="CDD:206700"
     Site            97..102
                     /site_type="other"
                     /note="Rab family motif 5 (RabF5)"
                     /db_xref="CDD:206700"
     Site            120..130
                     /site_type="other"
                     /note="Rab subfamily motif 3 (RabSF3)"
                     /db_xref="CDD:206700"
     Site            133..136
                     /site_type="other"
                     /note="G4 box"
                     /db_xref="CDD:206700"
     Site            163..165
                     /site_type="other"
                     /note="G5 box"
                     /db_xref="CDD:206700"
     Site            179..185
                     /site_type="other"
                     /note="Rab subfamily motif 4 (RabSF4)"
                     /db_xref="CDD:206700"
     CDS             1..221
                     /gene="RAB27A"
                     /gene_synonym="GS2; HsT18676; RAB27; RAM"
                     /coded_by="XM_047432918.1:3683..4348"
                     /db_xref="GeneID:5873"
                     /db_xref="HGNC:HGNC:9766"
                     /db_xref="MIM:603868"
ORIGIN      
        1 msdgdydyli kflalgdsgv gktsvlyqyt dgkfnskfit tvgidfrekr vvyrasgpdg
       61 atgrgqrihl qlwdtagqer frslttaffr damgflllfd ltneqsflnv rnwisqlqmh
      121 aycenpdivl cgnksdledq rvvkeeeaia laekygipyf etsaangtni sqaiemlldl
      181 imkrmercvd kswipegvvr snghastdql seekekgacg c
//
LOCUS       XP_047288876             221 aa            linear   PRI 05-AUG-2025
DEFINITION  ras-related protein Rab-27A isoform X1 [Homo sapiens].
ACCESSION   XP_047288876
VERSION     XP_047288876.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432920.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..221
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..221
                     /product="ras-related protein Rab-27A isoform X1"
                     /calculated_mol_wt=24737
     Region          6..185
                     /region_name="Rab27A"
                     /note="Rab GTPase family 27a (Rab27a); cd04127"
                     /db_xref="CDD:206700"
     Site            6..11
                     /site_type="other"
                     /note="Rab subfamily motif 1 (RabSF1)"
                     /db_xref="CDD:206700"
     Site            16..23
                     /site_type="other"
                     /note="G1 box"
                     /db_xref="CDD:206700"
     Site            order(19..24,134,136,164..165)
                     /site_type="other"
                     /note="GTP/Mg2+ binding site [chemical binding]"
                     /db_xref="CDD:206700"
     Site            order(24..34,39..40)
                     /site_type="other"
                     /note="Rab subfamily motif 2 (RabSF2)"
                     /db_xref="CDD:206700"
     Site            order(34,39..47)
                     /site_type="other"
                     /note="Switch I region"
                     /db_xref="CDD:206700"
     Site            order(39,43..50,67,69)
                     /site_type="other"
                     /note="putative GEF interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:206700"
     Site            41
                     /site_type="other"
                     /note="G2 box"
                     /db_xref="CDD:206700"
     Site            order(42,44..46,71,73,80..81,84,88,90..93)
                     /site_type="active"
                     /note="putative effector interaction site [active]"
                     /db_xref="CDD:206700"
     Site            order(42..43,45,73..74,81,83,85..87)
                     /site_type="other"
                     /note="putative GDI interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:206700"
     Site            42..46
                     /site_type="other"
                     /note="Rab family motif 1 (RabF1)"
                     /db_xref="CDD:206700"
     Site            69..73
                     /site_type="other"
                     /note="Rab family motif 2 (RabF2)"
                     /db_xref="CDD:206700"
     Site            74..77
                     /site_type="other"
                     /note="G3 box"
                     /db_xref="CDD:206700"
     Site            order(77,79..89)
                     /site_type="other"
                     /note="Switch II region"
                     /db_xref="CDD:206700"
     Site            80..85
                     /site_type="other"
                     /note="Rab family motif 3 (RabF3)"
                     /db_xref="CDD:206700"
     Site            88..92
                     /site_type="other"
                     /note="Rab family motif 4 (RabF4)"
                     /db_xref="CDD:206700"
     Site            97..102
                     /site_type="other"
                     /note="Rab family motif 5 (RabF5)"
                     /db_xref="CDD:206700"
     Site            120..130
                     /site_type="other"
                     /note="Rab subfamily motif 3 (RabSF3)"
                     /db_xref="CDD:206700"
     Site            133..136
                     /site_type="other"
                     /note="G4 box"
                     /db_xref="CDD:206700"
     Site            163..165
                     /site_type="other"
                     /note="G5 box"
                     /db_xref="CDD:206700"
     Site            179..185
                     /site_type="other"
                     /note="Rab subfamily motif 4 (RabSF4)"
                     /db_xref="CDD:206700"
     CDS             1..221
                     /gene="RAB27A"
                     /gene_synonym="GS2; HsT18676; RAB27; RAM"
                     /coded_by="XM_047432920.1:433..1098"
                     /db_xref="GeneID:5873"
                     /db_xref="HGNC:HGNC:9766"
                     /db_xref="MIM:603868"
ORIGIN      
        1 msdgdydyli kflalgdsgv gktsvlyqyt dgkfnskfit tvgidfrekr vvyrasgpdg
       61 atgrgqrihl qlwdtagqer frslttaffr damgflllfd ltneqsflnv rnwisqlqmh
      121 aycenpdivl cgnksdledq rvvkeeeaia laekygipyf etsaangtni sqaiemlldl
      181 imkrmercvd kswipegvvr snghastdql seekekgacg c
//
LOCUS       XP_047288879             221 aa            linear   PRI 05-AUG-2025
DEFINITION  ras-related protein Rab-27A isoform X1 [Homo sapiens].
ACCESSION   XP_047288879
VERSION     XP_047288879.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432923.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..221
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..221
                     /product="ras-related protein Rab-27A isoform X1"
                     /calculated_mol_wt=24737
     Region          6..185
                     /region_name="Rab27A"
                     /note="Rab GTPase family 27a (Rab27a); cd04127"
                     /db_xref="CDD:206700"
     Site            6..11
                     /site_type="other"
                     /note="Rab subfamily motif 1 (RabSF1)"
                     /db_xref="CDD:206700"
     Site            16..23
                     /site_type="other"
                     /note="G1 box"
                     /db_xref="CDD:206700"
     Site            order(19..24,134,136,164..165)
                     /site_type="other"
                     /note="GTP/Mg2+ binding site [chemical binding]"
                     /db_xref="CDD:206700"
     Site            order(24..34,39..40)
                     /site_type="other"
                     /note="Rab subfamily motif 2 (RabSF2)"
                     /db_xref="CDD:206700"
     Site            order(34,39..47)
                     /site_type="other"
                     /note="Switch I region"
                     /db_xref="CDD:206700"
     Site            order(39,43..50,67,69)
                     /site_type="other"
                     /note="putative GEF interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:206700"
     Site            41
                     /site_type="other"
                     /note="G2 box"
                     /db_xref="CDD:206700"
     Site            order(42,44..46,71,73,80..81,84,88,90..93)
                     /site_type="active"
                     /note="putative effector interaction site [active]"
                     /db_xref="CDD:206700"
     Site            order(42..43,45,73..74,81,83,85..87)
                     /site_type="other"
                     /note="putative GDI interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:206700"
     Site            42..46
                     /site_type="other"
                     /note="Rab family motif 1 (RabF1)"
                     /db_xref="CDD:206700"
     Site            69..73
                     /site_type="other"
                     /note="Rab family motif 2 (RabF2)"
                     /db_xref="CDD:206700"
     Site            74..77
                     /site_type="other"
                     /note="G3 box"
                     /db_xref="CDD:206700"
     Site            order(77,79..89)
                     /site_type="other"
                     /note="Switch II region"
                     /db_xref="CDD:206700"
     Site            80..85
                     /site_type="other"
                     /note="Rab family motif 3 (RabF3)"
                     /db_xref="CDD:206700"
     Site            88..92
                     /site_type="other"
                     /note="Rab family motif 4 (RabF4)"
                     /db_xref="CDD:206700"
     Site            97..102
                     /site_type="other"
                     /note="Rab family motif 5 (RabF5)"
                     /db_xref="CDD:206700"
     Site            120..130
                     /site_type="other"
                     /note="Rab subfamily motif 3 (RabSF3)"
                     /db_xref="CDD:206700"
     Site            133..136
                     /site_type="other"
                     /note="G4 box"
                     /db_xref="CDD:206700"
     Site            163..165
                     /site_type="other"
                     /note="G5 box"
                     /db_xref="CDD:206700"
     Site            179..185
                     /site_type="other"
                     /note="Rab subfamily motif 4 (RabSF4)"
                     /db_xref="CDD:206700"
     CDS             1..221
                     /gene="RAB27A"
                     /gene_synonym="GS2; HsT18676; RAB27; RAM"
                     /coded_by="XM_047432923.1:336..1001"
                     /db_xref="GeneID:5873"
                     /db_xref="HGNC:HGNC:9766"
                     /db_xref="MIM:603868"
ORIGIN      
        1 msdgdydyli kflalgdsgv gktsvlyqyt dgkfnskfit tvgidfrekr vvyrasgpdg
       61 atgrgqrihl qlwdtagqer frslttaffr damgflllfd ltneqsflnv rnwisqlqmh
      121 aycenpdivl cgnksdledq rvvkeeeaia laekygipyf etsaangtni sqaiemlldl
      181 imkrmercvd kswipegvvr snghastdql seekekgacg c
//
LOCUS       XP_011520159             369 aa            linear   PRI 05-AUG-2025
DEFINITION  DNA repair protein RAD51 homolog 1 isoform X1 [Homo sapiens].
ACCESSION   XP_011520159
VERSION     XP_011520159.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521857.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XP_011520159.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..369
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..369
                     /product="DNA repair protein RAD51 homolog 1 isoform X1"
                     /calculated_mol_wt=40209
     Region          55..369
                     /region_name="recomb_RAD51"
                     /note="DNA repair protein RAD51; TIGR02239"
                     /db_xref="CDD:274048"
     CDS             1..369
                     /gene="RAD51"
                     /gene_synonym="BRCC5; FANCR; HRAD51; HsRad51; HsT16930;
                     MRMV2; RAD51A; RECA"
                     /coded_by="XM_011521857.3:1..1110"
                     /db_xref="GeneID:5888"
                     /db_xref="HGNC:HGNC:9817"
                     /db_xref="MIM:179617"
ORIGIN      
        1 mhagrcspgp thyllgvvvf dlvnrrrqlv mamqmqlean adtsveeesf gpqpisrleq
       61 cginandvkk leeagfhtve avayapkkel inikgiseak adkilaeaak lvpmgfttat
      121 efhqrrseii qittgskeld kllqggietg sitemfgefr tgktqichtl avtcqlpidr
      181 gggegkamyi dtegtfrper llavaerygl sgsdvldnva yarafntdhq tqllyqasam
      241 mvesryalli vdsatalyrt dysgrgelsa rqmhlarflr mllrladefg vavvitnqvv
      301 aqvdgaamfa adpkkpiggn iiahasttrl ylrkgrgetr ickiydspcl peaeamfain
      361 adgvgdakd
//
LOCUS       XP_011520162             339 aa            linear   PRI 05-AUG-2025
DEFINITION  DNA repair protein RAD51 homolog 1 isoform X2 [Homo sapiens].
ACCESSION   XP_011520162
VERSION     XP_011520162.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521860.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..339
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..339
                     /product="DNA repair protein RAD51 homolog 1 isoform X2"
                     /calculated_mol_wt=36835
     Region          25..339
                     /region_name="recomb_RAD51"
                     /note="DNA repair protein RAD51; TIGR02239"
                     /db_xref="CDD:274048"
     CDS             1..339
                     /gene="RAD51"
                     /gene_synonym="BRCC5; FANCR; HRAD51; HsRad51; HsT16930;
                     MRMV2; RAD51A; RECA"
                     /coded_by="XM_011521860.3:151..1170"
                     /db_xref="GeneID:5888"
                     /db_xref="HGNC:HGNC:9817"
                     /db_xref="MIM:179617"
ORIGIN      
        1 mamqmqlean adtsveeesf gpqpisrleq cginandvkk leeagfhtve avayapkkel
       61 inikgiseak adkilaeaak lvpmgfttat efhqrrseii qittgskeld kllqggietg
      121 sitemfgefr tgktqichtl avtcqlpidr gggegkamyi dtegtfrper llavaerygl
      181 sgsdvldnva yarafntdhq tqllyqasam mvesryalli vdsatalyrt dysgrgelsa
      241 rqmhlarflr mllrladefg vavvitnqvv aqvdgaamfa adpkkpiggn iiahasttrl
      301 ylrkgrgetr ickiydspcl peaeamfain adgvgdakd
//
LOCUS       XP_011520161             339 aa            linear   PRI 05-AUG-2025
DEFINITION  DNA repair protein RAD51 homolog 1 isoform X2 [Homo sapiens].
ACCESSION   XP_011520161
VERSION     XP_011520161.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521859.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..339
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..339
                     /product="DNA repair protein RAD51 homolog 1 isoform X2"
                     /calculated_mol_wt=36835
     Region          25..339
                     /region_name="recomb_RAD51"
                     /note="DNA repair protein RAD51; TIGR02239"
                     /db_xref="CDD:274048"
     CDS             1..339
                     /gene="RAD51"
                     /gene_synonym="BRCC5; FANCR; HRAD51; HsRad51; HsT16930;
                     MRMV2; RAD51A; RECA"
                     /coded_by="XM_011521859.3:235..1254"
                     /db_xref="GeneID:5888"
                     /db_xref="HGNC:HGNC:9817"
                     /db_xref="MIM:179617"
ORIGIN      
        1 mamqmqlean adtsveeesf gpqpisrleq cginandvkk leeagfhtve avayapkkel
       61 inikgiseak adkilaeaak lvpmgfttat efhqrrseii qittgskeld kllqggietg
      121 sitemfgefr tgktqichtl avtcqlpidr gggegkamyi dtegtfrper llavaerygl
      181 sgsdvldnva yarafntdhq tqllyqasam mvesryalli vdsatalyrt dysgrgelsa
      241 rqmhlarflr mllrladefg vavvitnqvv aqvdgaamfa adpkkpiggn iiahasttrl
      301 ylrkgrgetr ickiydspcl peaeamfain adgvgdakd
//
LOCUS       XP_011520160             339 aa            linear   PRI 05-AUG-2025
DEFINITION  DNA repair protein RAD51 homolog 1 isoform X2 [Homo sapiens].
ACCESSION   XP_011520160
VERSION     XP_011520160.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521858.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..339
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..339
                     /product="DNA repair protein RAD51 homolog 1 isoform X2"
                     /calculated_mol_wt=36835
     Region          25..339
                     /region_name="recomb_RAD51"
                     /note="DNA repair protein RAD51; TIGR02239"
                     /db_xref="CDD:274048"
     CDS             1..339
                     /gene="RAD51"
                     /gene_synonym="BRCC5; FANCR; HRAD51; HsRad51; HsT16930;
                     MRMV2; RAD51A; RECA"
                     /coded_by="XM_011521858.3:98..1117"
                     /db_xref="GeneID:5888"
                     /db_xref="HGNC:HGNC:9817"
                     /db_xref="MIM:179617"
ORIGIN      
        1 mamqmqlean adtsveeesf gpqpisrleq cginandvkk leeagfhtve avayapkkel
       61 inikgiseak adkilaeaak lvpmgfttat efhqrrseii qittgskeld kllqggietg
      121 sitemfgefr tgktqichtl avtcqlpidr gggegkamyi dtegtfrper llavaerygl
      181 sgsdvldnva yarafntdhq tqllyqasam mvesryalli vdsatalyrt dysgrgelsa
      241 rqmhlarflr mllrladefg vavvitnqvv aqvdgaamfa adpkkpiggn iiahasttrl
      301 ylrkgrgetr ickiydspcl peaeamfain adgvgdakd
//
LOCUS       XP_011520163             310 aa            linear   PRI 05-AUG-2025
DEFINITION  DNA repair protein RAD51 homolog 1 isoform X3 [Homo sapiens].
ACCESSION   XP_011520163
VERSION     XP_011520163.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521861.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XP_011520163.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..310
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..310
                     /product="DNA repair protein RAD51 homolog 1 isoform X3"
                     /calculated_mol_wt=34244
     Region          55..>288
                     /region_name="recomb_RAD51"
                     /note="DNA repair protein RAD51; TIGR02239"
                     /db_xref="CDD:274048"
     CDS             1..310
                     /gene="RAD51"
                     /gene_synonym="BRCC5; FANCR; HRAD51; HsRad51; HsT16930;
                     MRMV2; RAD51A; RECA"
                     /coded_by="XM_011521861.3:1..933"
                     /db_xref="GeneID:5888"
                     /db_xref="HGNC:HGNC:9817"
                     /db_xref="MIM:179617"
ORIGIN      
        1 mhagrcspgp thyllgvvvf dlvnrrrqlv mamqmqlean adtsveeesf gpqpisrleq
       61 cginandvkk leeagfhtve avayapkkel inikgiseak adkilaeaak lvpmgfttat
      121 efhqrrseii qittgskeld kllqggietg sitemfgefr tgktqichtl avtcqlpidr
      181 gggegkamyi dtegtfrper llavaerygl sgsdvldnva yarafntdhq tqllyqasam
      241 mvesryalli vdsatalyrt dysgrgelsa rqmhlarflr mllrladeiv seerkrgnqn
      301 lqnlrlslss
//
LOCUS       XP_047288881             215 aa            linear   PRI 05-AUG-2025
DEFINITION  DNA repair protein RAD51 homolog 1 isoform X4 [Homo sapiens].
ACCESSION   XP_047288881
VERSION     XP_047288881.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432925.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..215
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..215
                     /product="DNA repair protein RAD51 homolog 1 isoform X4"
                     /calculated_mol_wt=23376
     Region          1..212
                     /region_name="Rad51"
                     /note="RAD51D recombinase; cd19513"
                     /db_xref="CDD:410921"
     Site            order(2..6,36,39..46,48,62,64..69,71..72,74..75,79,82..83,
                     86,103,105,109..111,119,123,126,133,144..147,149..150,
                     166..167,169..171,175,191..192,194..195)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:410921"
     Site            order(5..11,39,46,186,205..207)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:410921"
     Site            order(5,34,36,40,42..45,62..63,65..69,71,79,82..83,
                     102..103,122,126,129,133,170,173,194..195)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:410921"
     Site            order(34,36,42,44,47,62..63,65..68,71,75,79..82,84..86,88,
                     123,126..127,130..131,134..135)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:410921"
     Site            order(105,111,114..115,117..118,146..149,161,163..167)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410921"
     CDS             1..215
                     /gene="RAD51"
                     /gene_synonym="BRCC5; FANCR; HRAD51; HsRad51; HsT16930;
                     MRMV2; RAD51A; RECA"
                     /coded_by="XM_047432925.1:100..747"
                     /db_xref="GeneID:5888"
                     /db_xref="HGNC:HGNC:9817"
                     /db_xref="MIM:179617"
ORIGIN      
        1 mfgefrtgkt qichtlavtc qlpidrggge gkamyidteg tfrperllav aeryglsgsd
       61 vldnvayara fntdhqtqll yqasammves ryallivdsa talyrtdysg rgelsarqmh
      121 larflrmllr ladefgvavv itnqvvaqvd gaamfaadpk kpiggniiah asttrlylrk
      181 grgetricki ydspclpeae amfainadgv gdakd
//
LOCUS       XP_016877944            1270 aa            linear   PRI 05-AUG-2025
DEFINITION  ras-specific guanine nucleotide-releasing factor 1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_016877944
VERSION     XP_016877944.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022455.3
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 1% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1270
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1270
                     /product="ras-specific guanine nucleotide-releasing factor
                     1 isoform X1"
                     /calculated_mol_wt=144648
     Region          19..154
                     /region_name="PH_RasGRF1_2"
                     /note="Ras-specific guanine nucleotide-releasing factors 1
                     and 2 Pleckstrin homology (PH) domain; cd13261"
                     /db_xref="CDD:270081"
     Region          244..425
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; smart00325"
                     /db_xref="CDD:214619"
     Site            order(247,251,348,375..376,379..380,382..383,386..387,
                     390..391,394,420,424)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          431..582
                     /region_name="PH-like"
                     /note="Pleckstrin homology-like domain; cl17171"
                     /db_xref="CDD:473070"
     Region          647..>695
                     /region_name="RasGEF_N"
                     /note="RasGEF N-terminal motif; pfam00618"
                     /db_xref="CDD:459873"
     Region          <935..1004
                     /region_name="REM"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     GTPases; N-terminal domain (RasGef_N), also called REM
                     domain (Ras exchanger motif). This domain is common in
                     nucleotide exchange factors for Ras-like small GTPases and
                     is typically found immediately...; cl02520"
                     /db_xref="CDD:470601"
     Region          1031..1267
                     /region_name="RasGEF"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     small GTPases; smart00147"
                     /db_xref="CDD:214539"
     Site            order(1064..1066,1076..1077,1079..1081,1083..1084,
                     1087..1088,1091,1124,1127..1128,1130..1132,1134..1137,
                     1139..1140,1160,1163,1168..1170,1173,1186..1188,
                     1191..1193,1195..1197,1199..1202,1217,1221,1255,
                     1258..1259)
                     /site_type="other"
                     /note="Ras interaction site [polypeptide binding]"
                     /db_xref="CDD:238087"
     CDS             1..1270
                     /gene="RASGRF1"
                     /gene_synonym="CDC25; CDC25L; GNRP; GRF1; GRF55; H-GRF55;
                     PP13187; ras-GRF1"
                     /coded_by="XM_017022455.3:283..4095"
                     /db_xref="GeneID:5923"
                     /db_xref="HGNC:HGNC:9875"
                     /db_xref="MIM:606600"
ORIGIN      
        1 mqkgirlndg hvaslgllar kdgtrkgyls krssdntkwq tkwfallqnl lfyfesdsss
       61 rpsglylleg cvcdrapspk palsakeple kqhyftvnfs henqkalelr tedakdcdew
      121 vaaiahasyr tlatehealm qkylhllqiv etektvakql rqqiedgeie ierlkaeits
      181 llkdneriqs tqtvapnded sdikkikkvq sflrgwlcrr kwktiiqdyi rsphadsmrk
      241 rnqvvfsmle aeaeyvqqlh ilvnnflrpl rmaasskkpp ithddvssif lnsetimflh
      301 qifyqglkar isswptlvla dlfdillpml niyqefvrnh qyslqilahc kqnrdfdkll
      361 khyeakpdce ertletflty pmfqipryil tlhellahtp hehvernsld yakskleels
      421 rimhdevset enirknlaie rmiiegceil ldtsqtfvrq gsliqvpmse kgkitrgrlg
      481 slslkkeger qcflfskhli ictrgsggkl hltkngvisl idctlleepe steeeakgsg
      541 qdidhldfki gvepkdsppf tvilvassrq ekaawtsdis qcvdnircng lmmnafeens
      601 kvtvpqmikr tregtreaem srsdaslycd dvdirfsktm nsckvlqiry asverllerl
      661 tdlrflsidf lntflhsyrv fttaivvldk litiykkpis aiparslell fasgqnnkll
      721 ygeppkspra trkfsspppl sitktsspsr rrklslnipi itggkaldla alscnsngyt
      781 smysamspfs katldtskly vsssftnkip degdttpekp edpsalskqs sevsmreesd
      841 idqnqsddgd tetsptkspt tpksvknkns sefplfsynn gvvmtscrel dnnrsalsaa
      901 safaiataga negtpnkeky rrmslasagf ppdqrngdke fvirraatnr vlnvlrhwvs
      961 khsqdfetnd elkckvigfl eevmhdpell tqerkaaani irtltqedpg dnqitleeit
     1021 qmaegvkaep fenhsaleia eqltlldhlv fkkipyeeff gqgwmklekn ertpyimktt
     1081 khfndisnli aseiirnedi narvsaiekw vavadicrcl hnynavleit ssmnrsaifr
     1141 lkktwlkvsk qtkalidklq klvssegrfk nlrealkncd ppcvpylgmy ltdlafieeg
     1201 tpnytedglv nfskmrmish iireirqfqq taykiehqak vtqylldqsf vmdeeslyes
     1261 slriepklpt
//
LOCUS       XP_011520168            1261 aa            linear   PRI 05-AUG-2025
DEFINITION  ras-specific guanine nucleotide-releasing factor 1 isoform X2 [Homo
            sapiens].
ACCESSION   XP_011520168
VERSION     XP_011520168.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521866.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1261
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1261
                     /product="ras-specific guanine nucleotide-releasing factor
                     1 isoform X2"
                     /calculated_mol_wt=142679
     Region          19..154
                     /region_name="PH_RasGRF1_2"
                     /note="Ras-specific guanine nucleotide-releasing factors 1
                     and 2 Pleckstrin homology (PH) domain; cd13261"
                     /db_xref="CDD:270081"
     Region          244..425
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; smart00325"
                     /db_xref="CDD:214619"
     Site            order(247,251,348,375..376,379..380,382..383,386..387,
                     390..391,394,420,424)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          431..582
                     /region_name="PH-like"
                     /note="Pleckstrin homology-like domain; cl17171"
                     /db_xref="CDD:473070"
     Region          647..>695
                     /region_name="RasGEF_N"
                     /note="RasGEF N-terminal motif; pfam00618"
                     /db_xref="CDD:459873"
     Region          <938..1007
                     /region_name="REM"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     GTPases; N-terminal domain (RasGef_N), also called REM
                     domain (Ras exchanger motif). This domain is common in
                     nucleotide exchange factors for Ras-like small GTPases and
                     is typically found immediately...; cl02520"
                     /db_xref="CDD:470601"
     Region          1041..>1181
                     /region_name="RasGEF"
                     /note="RasGEF domain; pfam00617"
                     /db_xref="CDD:459872"
     CDS             1..1261
                     /gene="RASGRF1"
                     /gene_synonym="CDC25; CDC25L; GNRP; GRF1; GRF55; H-GRF55;
                     PP13187; ras-GRF1"
                     /coded_by="XM_011521866.4:283..4068"
                     /db_xref="GeneID:5923"
                     /db_xref="HGNC:HGNC:9875"
                     /db_xref="MIM:606600"
ORIGIN      
        1 mqkgirlndg hvaslgllar kdgtrkgyls krssdntkwq tkwfallqnl lfyfesdsss
       61 rpsglylleg cvcdrapspk palsakeple kqhyftvnfs henqkalelr tedakdcdew
      121 vaaiahasyr tlatehealm qkylhllqiv etektvakql rqqiedgeie ierlkaeits
      181 llkdneriqs tqtvapnded sdikkikkvq sflrgwlcrr kwktiiqdyi rsphadsmrk
      241 rnqvvfsmle aeaeyvqqlh ilvnnflrpl rmaasskkpp ithddvssif lnsetimflh
      301 qifyqglkar isswptlvla dlfdillpml niyqefvrnh qyslqilahc kqnrdfdkll
      361 khyeakpdce ertletflty pmfqipryil tlhellahtp hehvernsld yakskleels
      421 rimhdevset enirknlaie rmiiegceil ldtsqtfvrq gsliqvpmse kgkitrgrlg
      481 slslkkeger qcflfskhli ictrgsggkl hltkngvisl idctlleepe steeeakgsg
      541 qdidhldfki gvepkdsppf tvilvassrq ekaawtsdis qcvdnircng lmmnafeens
      601 kvtvpqmikr tregtreaem srsdaslycd dvdirfsktm nsckvlqiry asverllerl
      661 tdlrflsidf lntflhsyrv fttaivvldk litiykkpis aiparwlrsl ellfasgqnn
      721 kllygeppks pratrkfssp pplsitktss psrrrklsln ipiitggkal dlaalscnsn
      781 gytsmysams pfskatldts klyvsssftn kipdegdttp ekpedpsals kqssevsmre
      841 esdidqnqsd dgdtetsptk spttpksvkn knssefplfs ynngvvmtsc reldnnrsal
      901 saasafaiat aganegtpnk ekyrrmslas agfppdqrng dkefvirraa tnrvlnvlrh
      961 wvskhsqdfe tndelkckvi gfleevmhdp elltqerkaa aniirtltqe dpgdnqitle
     1021 eitqmaegvk aepfenhsal eiaeqltlld hlvfkkipye effgqgwmkl eknertpyim
     1081 kttkhfndis nliaseiirn edinarvsai ekwvavadic rclhnynavl eitssmnrsa
     1141 ifrlkktwlk vskqtkalid klqklvsseg rfknlrealk kqmlhpsvls srlssawape
     1201 spcglclwga apsvhsptcp svrprgttps tsshgwlprl ppppplpplp lgppilsesp
     1261 p
//
LOCUS       XP_016877945            1260 aa            linear   PRI 05-AUG-2025
DEFINITION  ras-specific guanine nucleotide-releasing factor 1 isoform X3 [Homo
            sapiens].
ACCESSION   XP_016877945
VERSION     XP_016877945.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022456.3
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 1% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1260
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1260
                     /product="ras-specific guanine nucleotide-releasing factor
                     1 isoform X3"
                     /calculated_mol_wt=143543
     Region          19..154
                     /region_name="PH_RasGRF1_2"
                     /note="Ras-specific guanine nucleotide-releasing factors 1
                     and 2 Pleckstrin homology (PH) domain; cd13261"
                     /db_xref="CDD:270081"
     Region          244..425
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; smart00325"
                     /db_xref="CDD:214619"
     Site            order(247,251,348,375..376,379..380,382..383,386..387,
                     390..391,394,420,424)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          431..582
                     /region_name="PH-like"
                     /note="Pleckstrin homology-like domain; cl17171"
                     /db_xref="CDD:473070"
     Region          634..>682
                     /region_name="RasGEF_N"
                     /note="RasGEF N-terminal motif; pfam00618"
                     /db_xref="CDD:459873"
     Region          <925..994
                     /region_name="REM"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     GTPases; N-terminal domain (RasGef_N), also called REM
                     domain (Ras exchanger motif). This domain is common in
                     nucleotide exchange factors for Ras-like small GTPases and
                     is typically found immediately...; cl02520"
                     /db_xref="CDD:470601"
     Region          1021..1257
                     /region_name="RasGEF"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     small GTPases; smart00147"
                     /db_xref="CDD:214539"
     Site            order(1054..1056,1066..1067,1069..1071,1073..1074,
                     1077..1078,1081,1114,1117..1118,1120..1122,1124..1127,
                     1129..1130,1150,1153,1158..1160,1163,1176..1178,
                     1181..1183,1185..1187,1189..1192,1207,1211,1245,
                     1248..1249)
                     /site_type="other"
                     /note="Ras interaction site [polypeptide binding]"
                     /db_xref="CDD:238087"
     CDS             1..1260
                     /gene="RASGRF1"
                     /gene_synonym="CDC25; CDC25L; GNRP; GRF1; GRF55; H-GRF55;
                     PP13187; ras-GRF1"
                     /coded_by="XM_017022456.3:283..4065"
                     /db_xref="GeneID:5923"
                     /db_xref="HGNC:HGNC:9875"
                     /db_xref="MIM:606600"
ORIGIN      
        1 mqkgirlndg hvaslgllar kdgtrkgyls krssdntkwq tkwfallqnl lfyfesdsss
       61 rpsglylleg cvcdrapspk palsakeple kqhyftvnfs henqkalelr tedakdcdew
      121 vaaiahasyr tlatehealm qkylhllqiv etektvakql rqqiedgeie ierlkaeits
      181 llkdneriqs tqtvapnded sdikkikkvq sflrgwlcrr kwktiiqdyi rsphadsmrk
      241 rnqvvfsmle aeaeyvqqlh ilvnnflrpl rmaasskkpp ithddvssif lnsetimflh
      301 qifyqglkar isswptlvla dlfdillpml niyqefvrnh qyslqilahc kqnrdfdkll
      361 khyeakpdce ertletflty pmfqipryil tlhellahtp hehvernsld yakskleels
      421 rimhdevset enirknlaie rmiiegceil ldtsqtfvrq gsliqvpmse kgkitrgrlg
      481 slslkkeger qcflfskhli ictrgsggkl hltkngvisl idctlleepe steeeakgsg
      541 qdidhldfki gvepkdsppf tvilvassrq ekaawtsdis qcvdnircng lmmnafeens
      601 kvtvpqmiks daslycddvd irfsktmnsc kvlqiryasv erllerltdl rflsidflnt
      661 flhsyrvftt aivvldklit iykkpisaip arwlrslell fasgqnnkll ygeppkspra
      721 trkfsspppl sitktsspsr rrklslnipi itggkaldla alscnsngyt smysamspfs
      781 katldtskly vsssftnkip degdttpekp edpsalskqs sevsmreesd idqnqsddgd
      841 tetsptkspt tpksvknkns sefplfsynn gvvmtscrel dnnrsalsaa safaiataga
      901 negtpnkeky rrmslasagf ppdqrngdke fvirraatnr vlnvlrhwvs khsqdfetnd
      961 elkckvigfl eevmhdpell tqerkaaani irtltqedpg dnqitleeit qmaegvkaep
     1021 fenhsaleia eqltlldhlv fkkipyeeff gqgwmklekn ertpyimktt khfndisnli
     1081 aseiirnedi narvsaiekw vavadicrcl hnynavleit ssmnrsaifr lkktwlkvsk
     1141 qtkalidklq klvssegrfk nlrealkncd ppcvpylgmy ltdlafieeg tpnytedglv
     1201 nfskmrmish iireirqfqq taykiehqak vtqylldqsf vmdeeslyes slriepklpt
//
LOCUS       XP_016877946            1248 aa            linear   PRI 05-AUG-2025
DEFINITION  ras-specific guanine nucleotide-releasing factor 1 isoform X4 [Homo
            sapiens].
ACCESSION   XP_016877946
VERSION     XP_016877946.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022457.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1248
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1248
                     /product="ras-specific guanine nucleotide-releasing factor
                     1 isoform X4"
                     /calculated_mol_wt=141118
     Region          19..154
                     /region_name="PH_RasGRF1_2"
                     /note="Ras-specific guanine nucleotide-releasing factors 1
                     and 2 Pleckstrin homology (PH) domain; cd13261"
                     /db_xref="CDD:270081"
     Region          244..425
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; smart00325"
                     /db_xref="CDD:214619"
     Site            order(247,251,348,375..376,379..380,382..383,386..387,
                     390..391,394,420,424)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          431..582
                     /region_name="PH-like"
                     /note="Pleckstrin homology-like domain; cl17171"
                     /db_xref="CDD:473070"
     Region          634..>682
                     /region_name="RasGEF_N"
                     /note="RasGEF N-terminal motif; pfam00618"
                     /db_xref="CDD:459873"
     Region          <925..994
                     /region_name="REM"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     GTPases; N-terminal domain (RasGef_N), also called REM
                     domain (Ras exchanger motif). This domain is common in
                     nucleotide exchange factors for Ras-like small GTPases and
                     is typically found immediately...; cl02520"
                     /db_xref="CDD:470601"
     Region          1028..>1168
                     /region_name="RasGEF"
                     /note="RasGEF domain; pfam00617"
                     /db_xref="CDD:459872"
     CDS             1..1248
                     /gene="RASGRF1"
                     /gene_synonym="CDC25; CDC25L; GNRP; GRF1; GRF55; H-GRF55;
                     PP13187; ras-GRF1"
                     /coded_by="XM_017022457.3:283..4029"
                     /db_xref="GeneID:5923"
                     /db_xref="HGNC:HGNC:9875"
                     /db_xref="MIM:606600"
ORIGIN      
        1 mqkgirlndg hvaslgllar kdgtrkgyls krssdntkwq tkwfallqnl lfyfesdsss
       61 rpsglylleg cvcdrapspk palsakeple kqhyftvnfs henqkalelr tedakdcdew
      121 vaaiahasyr tlatehealm qkylhllqiv etektvakql rqqiedgeie ierlkaeits
      181 llkdneriqs tqtvapnded sdikkikkvq sflrgwlcrr kwktiiqdyi rsphadsmrk
      241 rnqvvfsmle aeaeyvqqlh ilvnnflrpl rmaasskkpp ithddvssif lnsetimflh
      301 qifyqglkar isswptlvla dlfdillpml niyqefvrnh qyslqilahc kqnrdfdkll
      361 khyeakpdce ertletflty pmfqipryil tlhellahtp hehvernsld yakskleels
      421 rimhdevset enirknlaie rmiiegceil ldtsqtfvrq gsliqvpmse kgkitrgrlg
      481 slslkkeger qcflfskhli ictrgsggkl hltkngvisl idctlleepe steeeakgsg
      541 qdidhldfki gvepkdsppf tvilvassrq ekaawtsdis qcvdnircng lmmnafeens
      601 kvtvpqmiks daslycddvd irfsktmnsc kvlqiryasv erllerltdl rflsidflnt
      661 flhsyrvftt aivvldklit iykkpisaip arwlrslell fasgqnnkll ygeppkspra
      721 trkfsspppl sitktsspsr rrklslnipi itggkaldla alscnsngyt smysamspfs
      781 katldtskly vsssftnkip degdttpekp edpsalskqs sevsmreesd idqnqsddgd
      841 tetsptkspt tpksvknkns sefplfsynn gvvmtscrel dnnrsalsaa safaiataga
      901 negtpnkeky rrmslasagf ppdqrngdke fvirraatnr vlnvlrhwvs khsqdfetnd
      961 elkckvigfl eevmhdpell tqerkaaani irtltqedpg dnqitleeit qmaegvkaep
     1021 fenhsaleia eqltlldhlv fkkipyeeff gqgwmklekn ertpyimktt khfndisnli
     1081 aseiirnedi narvsaiekw vavadicrcl hnynavleit ssmnrsaifr lkktwlkvsk
     1141 qtkalidklq klvssegrfk nlrealkkqm lhpsvlssrl ssawapespc glclwgaaps
     1201 vhsptcpsvr prgttpstss hgwlprlppp pplpplplgp pilsespp
//
LOCUS       XP_016877947            1245 aa            linear   PRI 05-AUG-2025
DEFINITION  ras-specific guanine nucleotide-releasing factor 1 isoform X5 [Homo
            sapiens].
ACCESSION   XP_016877947
VERSION     XP_016877947.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022458.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1245
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1245
                     /product="ras-specific guanine nucleotide-releasing factor
                     1 isoform X5"
                     /calculated_mol_wt=140662
     Region          19..154
                     /region_name="PH_RasGRF1_2"
                     /note="Ras-specific guanine nucleotide-releasing factors 1
                     and 2 Pleckstrin homology (PH) domain; cd13261"
                     /db_xref="CDD:270081"
     Region          244..425
                     /region_name="RhoGEF"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; smart00325"
                     /db_xref="CDD:214619"
     Site            order(247,251,348,375..376,379..380,382..383,386..387,
                     390..391,394,420,424)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:238091"
     Region          431..582
                     /region_name="PH-like"
                     /note="Pleckstrin homology-like domain; cl17171"
                     /db_xref="CDD:473070"
     Region          634..>682
                     /region_name="RasGEF_N"
                     /note="RasGEF N-terminal motif; pfam00618"
                     /db_xref="CDD:459873"
     Region          <922..991
                     /region_name="REM"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     GTPases; N-terminal domain (RasGef_N), also called REM
                     domain (Ras exchanger motif). This domain is common in
                     nucleotide exchange factors for Ras-like small GTPases and
                     is typically found immediately...; cl02520"
                     /db_xref="CDD:470601"
     Region          1025..>1165
                     /region_name="RasGEF"
                     /note="RasGEF domain; pfam00617"
                     /db_xref="CDD:459872"
     CDS             1..1245
                     /gene="RASGRF1"
                     /gene_synonym="CDC25; CDC25L; GNRP; GRF1; GRF55; H-GRF55;
                     PP13187; ras-GRF1"
                     /coded_by="XM_017022458.3:283..4020"
                     /db_xref="GeneID:5923"
                     /db_xref="HGNC:HGNC:9875"
                     /db_xref="MIM:606600"
ORIGIN      
        1 mqkgirlndg hvaslgllar kdgtrkgyls krssdntkwq tkwfallqnl lfyfesdsss
       61 rpsglylleg cvcdrapspk palsakeple kqhyftvnfs henqkalelr tedakdcdew
      121 vaaiahasyr tlatehealm qkylhllqiv etektvakql rqqiedgeie ierlkaeits
      181 llkdneriqs tqtvapnded sdikkikkvq sflrgwlcrr kwktiiqdyi rsphadsmrk
      241 rnqvvfsmle aeaeyvqqlh ilvnnflrpl rmaasskkpp ithddvssif lnsetimflh
      301 qifyqglkar isswptlvla dlfdillpml niyqefvrnh qyslqilahc kqnrdfdkll
      361 khyeakpdce ertletflty pmfqipryil tlhellahtp hehvernsld yakskleels
      421 rimhdevset enirknlaie rmiiegceil ldtsqtfvrq gsliqvpmse kgkitrgrlg
      481 slslkkeger qcflfskhli ictrgsggkl hltkngvisl idctlleepe steeeakgsg
      541 qdidhldfki gvepkdsppf tvilvassrq ekaawtsdis qcvdnircng lmmnafeens
      601 kvtvpqmiks daslycddvd irfsktmnsc kvlqiryasv erllerltdl rflsidflnt
      661 flhsyrvftt aivvldklit iykkpisaip arslellfas gqnnkllyge ppkspratrk
      721 fssppplsit ktsspsrrrk lslnipiitg gkaldlaals cnsngytsmy samspfskat
      781 ldtsklyvss sftnkipdeg dttpekpedp salskqssev smreesdidq nqsddgdtet
      841 sptkspttpk svknknssef plfsynngvv mtscreldnn rsalsaasaf aiataganeg
      901 tpnkekyrrm slasagfppd qrngdkefvi rraatnrvln vlrhwvskhs qdfetndelk
      961 ckvigfleev mhdpelltqe rkaaaniirt ltqedpgdnq itleeitqma egvkaepfen
     1021 hsaleiaeql tlldhlvfkk ipyeeffgqg wmkleknert pyimkttkhf ndisnliase
     1081 iirnedinar vsaiekwvav adicrclhny navleitssm nrsaifrlkk twlkvskqtk
     1141 alidklqklv ssegrfknlr ealkkqmlhp svlssrlssa wapespcglc lwgaapsvhs
     1201 ptcpsvrprg ttpstsshgw lprlpppppl pplplgppil sespp
//
LOCUS       XP_047288882             489 aa            linear   PRI 05-AUG-2025
DEFINITION  ras-specific guanine nucleotide-releasing factor 1 isoform X6 [Homo
            sapiens].
ACCESSION   XP_047288882
VERSION     XP_047288882.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432926.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..489
                     /product="ras-specific guanine nucleotide-releasing factor
                     1 isoform X6"
                     /calculated_mol_wt=55358
     Region          <154..223
                     /region_name="REM"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     GTPases; N-terminal domain (RasGef_N), also called REM
                     domain (Ras exchanger motif). This domain is common in
                     nucleotide exchange factors for Ras-like small GTPases and
                     is typically found immediately...; cl02520"
                     /db_xref="CDD:470601"
     Region          250..486
                     /region_name="RasGEF"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     small GTPases; smart00147"
                     /db_xref="CDD:214539"
     Site            order(283..285,295..296,298..300,302..303,306..307,310,
                     343,346..347,349..351,353..356,358..359,379,382,387..389,
                     392,405..407,410..412,414..416,418..421,436,440,474,
                     477..478)
                     /site_type="other"
                     /note="Ras interaction site [polypeptide binding]"
                     /db_xref="CDD:238087"
     CDS             1..489
                     /gene="RASGRF1"
                     /gene_synonym="CDC25; CDC25L; GNRP; GRF1; GRF55; H-GRF55;
                     PP13187; ras-GRF1"
                     /coded_by="XM_047432926.1:279..1748"
                     /db_xref="GeneID:5923"
                     /db_xref="HGNC:HGNC:9875"
                     /db_xref="MIM:606600"
ORIGIN      
        1 mysamspfsk atldtsklyv sssftnkipd egdttpekpe dpsalskqss evsmreesdi
       61 dqnqsddgdt etsptksptt pksvknknss efplfsynng vvmtscreld nnrsalsaas
      121 afaiatagan egtpnkekyr rmslasagfp pdqrngdkef virraatnrv lnvlrhwvsk
      181 hsqdfetnde lkckvigfle evmhdpellt qerkaaanii rtltqedpgd nqitleeitq
      241 maegvkaepf enhsaleiae qltlldhlvf kkipyeeffg qgwmklekne rtpyimkttk
      301 hfndisnlia seiirnedin arvsaiekwv avadicrclh nynavleits smnrsaifrl
      361 kktwlkvskq tkalidklqk lvssegrfkn lrealkncdp pcvpylgmyl tdlafieegt
      421 pnytedglvn fskmrmishi ireirqfqqt aykiehqakv tqylldqsfv mdeeslyess
      481 lriepklpt
//
LOCUS       XP_011520172             317 aa            linear   PRI 05-AUG-2025
DEFINITION  retinaldehyde-binding protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_011520172
VERSION     XP_011520172.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521870.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..317
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..317
                     /product="retinaldehyde-binding protein 1 isoform X1"
                     /calculated_mol_wt=36343
     Region          60..117
                     /region_name="CRAL_TRIO_N"
                     /note="CRAL/TRIO, N-terminal domain; smart01100"
                     /db_xref="CDD:215024"
     Region          141..292
                     /region_name="SEC14"
                     /note="Sec14p-like lipid-binding domain; cd00170"
                     /db_xref="CDD:469559"
     CDS             1..317
                     /gene="RLBP1"
                     /gene_synonym="CRALBP"
                     /coded_by="XM_011521870.3:210..1163"
                     /db_xref="GeneID:6017"
                     /db_xref="HGNC:HGNC:10024"
                     /db_xref="MIM:180090"
ORIGIN      
        1 msegvgtfrm vpeeeqelra qleqlttkdh gpvfgpcsql prhtlqkakd elnereetre
       61 eavrelqemv qaqaasgeel avavaervqe kdsgfflrfi rarkfnvgra yellrgyvnf
      121 rlqypelfds lspeavrcti eagypgvlss rdkygrvvml fnienwqsqe itfdeilqay
      181 cfilekllen eetqingfci ienfkgftmq qaaslrtsdl rkmvdmlqds fparfkaihf
      241 ihqpwyfttt ynvvkpflks kllervfvhg ddlsgfyqei denilpsdfg gtlpkydgka
      301 vaeqlfgpqa qaentaf
//
LOCUS       XP_047288883             317 aa            linear   PRI 05-AUG-2025
DEFINITION  retinaldehyde-binding protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047288883
VERSION     XP_047288883.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432927.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..317
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..317
                     /product="retinaldehyde-binding protein 1 isoform X1"
                     /calculated_mol_wt=36343
     Region          60..117
                     /region_name="CRAL_TRIO_N"
                     /note="CRAL/TRIO, N-terminal domain; smart01100"
                     /db_xref="CDD:215024"
     Region          141..292
                     /region_name="SEC14"
                     /note="Sec14p-like lipid-binding domain; cd00170"
                     /db_xref="CDD:469559"
     CDS             1..317
                     /gene="RLBP1"
                     /gene_synonym="CRALBP"
                     /coded_by="XM_047432927.1:2605..3558"
                     /db_xref="GeneID:6017"
                     /db_xref="HGNC:HGNC:10024"
                     /db_xref="MIM:180090"
ORIGIN      
        1 msegvgtfrm vpeeeqelra qleqlttkdh gpvfgpcsql prhtlqkakd elnereetre
       61 eavrelqemv qaqaasgeel avavaervqe kdsgfflrfi rarkfnvgra yellrgyvnf
      121 rlqypelfds lspeavrcti eagypgvlss rdkygrvvml fnienwqsqe itfdeilqay
      181 cfilekllen eetqingfci ienfkgftmq qaaslrtsdl rkmvdmlqds fparfkaihf
      241 ihqpwyfttt ynvvkpflks kllervfvhg ddlsgfyqei denilpsdfg gtlpkydgka
      301 vaeqlfgpqa qaentaf
//
LOCUS       XP_011520176             525 aa            linear   PRI 05-AUG-2025
DEFINITION  nuclear receptor ROR-alpha isoform X1 [Homo sapiens].
ACCESSION   XP_011520176
VERSION     XP_011520176.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521874.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..525
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..525
                     /product="nuclear receptor ROR-alpha isoform X1"
                     /calculated_mol_wt=59319
     Region          68..162
                     /region_name="NR_DBD_ROR"
                     /note="DNA-binding domain of Retinoid-related orphan
                     receptors (RORs) is composed of two C4-type zinc fingers;
                     cd06968"
                     /db_xref="CDD:143526"
     Site            order(75,78,92,95,111,117,127,130)
                     /site_type="other"
                     /note="zinc binding site [ion binding]"
                     /db_xref="CDD:143526"
     Site            order(85..87,93..94,96,98,101,104,124..125,128,131,142,
                     145)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143526"
     Region          274..513
                     /region_name="NR_LBD_ROR_like"
                     /note="The ligand binding domain of Retinoid-related
                     orphan receptors, of the nuclear receptor superfamily;
                     cd06939"
                     /db_xref="CDD:132737"
     Site            order(290..292,322,325..326,328..329,332,366,369..370,
                     372..373,381..383,393,396,405,486)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:132737"
     Site            order(341,351,354..355,358..359,507..508,511..512)
                     /site_type="other"
                     /note="coactivator recognition site [polypeptide binding]"
                     /db_xref="CDD:132737"
     CDS             1..525
                     /gene="RORA"
                     /gene_synonym="IDDECA; NR1F1; ROR1; ROR2; ROR3; RORa1;
                     RORalpha; RZR-ALPHA; RZRA"
                     /coded_by="XM_011521874.2:91..1668"
                     /db_xref="GeneID:6095"
                     /db_xref="HGNC:HGNC:10258"
                     /db_xref="MIM:600825"
ORIGIN      
        1 mrvtvapqtk pvfstnelah lsppsapasq resgvglras cptewgqkvv rgafrgalra
       61 ekrpaataqi eiipckicgd kssgihygvi tcegckgffr rsqqsnatys cprqknclid
      121 rtsrnrcqhc rlqkclavgm srdavkfgrm skkqrdslya evqkhrmqqq qrdhqqqpge
      181 aepltptyni sangltelhd dlsnyidght pegskadsav ssfyldiqps pdqsglding
      241 ikpepicdyt pasgffpycs ftngetsptv smaelehlaq niskshletc qylreelqqi
      301 twqtflqeei enyqnkqrev mwqlcaikit eaiqyvvefa kridgfmelc qndqivllka
      361 gslevvfirm crafdsqnnt vyfdgkyasp dvfkslgced fisfvfefgk slcsmhlted
      421 eialfsafvl msadrswlqe kvkieklqqk iqlalqhvlq knhredgilt klickvstlr
      481 alcgrhtekl mafkaiypdi vrlhfpplyk elftsefepa mqidg
//
LOCUS       XP_011520177             504 aa            linear   PRI 05-AUG-2025
DEFINITION  nuclear receptor ROR-alpha isoform X2 [Homo sapiens].
ACCESSION   XP_011520177
VERSION     XP_011520177.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521875.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..504
                     /product="nuclear receptor ROR-alpha isoform X2"
                     /calculated_mol_wt=57212
     Region          47..141
                     /region_name="NR_DBD_ROR"
                     /note="DNA-binding domain of Retinoid-related orphan
                     receptors (RORs) is composed of two C4-type zinc fingers;
                     cd06968"
                     /db_xref="CDD:143526"
     Site            order(54,57,71,74,90,96,106,109)
                     /site_type="other"
                     /note="zinc binding site [ion binding]"
                     /db_xref="CDD:143526"
     Site            order(64..66,72..73,75,77,80,83,103..104,107,110,121,124)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143526"
     Region          253..492
                     /region_name="NR_LBD_ROR_like"
                     /note="The ligand binding domain of Retinoid-related
                     orphan receptors, of the nuclear receptor superfamily;
                     cd06939"
                     /db_xref="CDD:132737"
     Site            order(269..271,301,304..305,307..308,311,345,348..349,
                     351..352,360..362,372,375,384,465)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:132737"
     Site            order(320,330,333..334,337..338,486..487,490..491)
                     /site_type="other"
                     /note="coactivator recognition site [polypeptide binding]"
                     /db_xref="CDD:132737"
     CDS             1..504
                     /gene="RORA"
                     /gene_synonym="IDDECA; NR1F1; ROR1; ROR2; ROR3; RORa1;
                     RORalpha; RZR-ALPHA; RZRA"
                     /coded_by="XM_011521875.3:225..1739"
                     /db_xref="GeneID:6095"
                     /db_xref="HGNC:HGNC:10258"
                     /db_xref="MIM:600825"
ORIGIN      
        1 madvllegav ssskweteai rtthavllkk ppgwksgisv tkkthtsqie iipckicgdk
       61 ssgihygvit cegckgffrr sqqsnatysc prqknclidr tsrnrcqhcr lqkclavgms
      121 rdavkfgrms kkqrdslyae vqkhrmqqqq rdhqqqpgea epltptynis angltelhdd
      181 lsnyidghtp egskadsavs sfyldiqpsp dqsgldingi kpepicdytp asgffpycsf
      241 tngetsptvs maelehlaqn iskshletcq ylreelqqit wqtflqeeie nyqnkqrevm
      301 wqlcaikite aiqyvvefak ridgfmelcq ndqivllkag slevvfirmc rafdsqnntv
      361 yfdgkyaspd vfkslgcedf isfvfefgks lcsmhltede ialfsafvlm sadrswlqek
      421 vkieklqqki qlalqhvlqk nhredgiltk lickvstlra lcgrhteklm afkaiypdiv
      481 rlhfpplyke lftsefepam qidg
//
LOCUS       XP_011520179             467 aa            linear   PRI 05-AUG-2025
DEFINITION  nuclear receptor ROR-alpha isoform X3 [Homo sapiens].
ACCESSION   XP_011520179
VERSION     XP_011520179.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521877.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..467
                     /product="nuclear receptor ROR-alpha isoform X3"
                     /calculated_mol_wt=53257
     Region          10..104
                     /region_name="NR_DBD_ROR"
                     /note="DNA-binding domain of Retinoid-related orphan
                     receptors (RORs) is composed of two C4-type zinc fingers;
                     cd06968"
                     /db_xref="CDD:143526"
     Site            order(17,20,34,37,53,59,69,72)
                     /site_type="other"
                     /note="zinc binding site [ion binding]"
                     /db_xref="CDD:143526"
     Site            order(27..29,35..36,38,40,43,46,66..67,70,73,84,87)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143526"
     Region          216..455
                     /region_name="NR_LBD_ROR_like"
                     /note="The ligand binding domain of Retinoid-related
                     orphan receptors, of the nuclear receptor superfamily;
                     cd06939"
                     /db_xref="CDD:132737"
     Site            order(232..234,264,267..268,270..271,274,308,311..312,
                     314..315,323..325,335,338,347,428)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:132737"
     Site            order(283,293,296..297,300..301,449..450,453..454)
                     /site_type="other"
                     /note="coactivator recognition site [polypeptide binding]"
                     /db_xref="CDD:132737"
     CDS             1..467
                     /gene="RORA"
                     /gene_synonym="IDDECA; NR1F1; ROR1; ROR2; ROR3; RORa1;
                     RORalpha; RZR-ALPHA; RZRA"
                     /coded_by="XM_011521877.4:1408..2811"
                     /db_xref="GeneID:6095"
                     /db_xref="HGNC:HGNC:10258"
                     /db_xref="MIM:600825"
ORIGIN      
        1 mkfregtaia qieiipckic gdkssgihyg vitcegckgf frrsqqsnat yscprqkncl
       61 idrtsrnrcq hcrlqkclav gmsrdavkfg rmskkqrdsl yaevqkhrmq qqqrdhqqqp
      121 geaepltpty nisangltel hddlsnyidg htpegskads avssfyldiq pspdqsgldi
      181 ngikpepicd ytpasgffpy csftngetsp tvsmaelehl aqniskshle tcqylreelq
      241 qitwqtflqe eienyqnkqr evmwqlcaik iteaiqyvve fakridgfme lcqndqivll
      301 kagslevvfi rmcrafdsqn ntvyfdgkya spdvfkslgc edfisfvfef gkslcsmhlt
      361 edeialfsaf vlmsadrswl qekvkieklq qkiqlalqhv lqknhredgi ltklickvst
      421 lralcgrhte klmafkaiyp divrlhfppl ykelftsefe pamqidg
//
LOCUS       XP_047288884             386 aa            linear   PRI 05-AUG-2025
DEFINITION  nuclear receptor ROR-alpha isoform X4 [Homo sapiens].
ACCESSION   XP_047288884
VERSION     XP_047288884.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432928.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 15% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..386
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..386
                     /product="nuclear receptor ROR-alpha isoform X4"
                     /calculated_mol_wt=44160
     Region          <1..23
                     /region_name="NR_DBD_like"
                     /note="DNA-binding domain of nuclear receptors is composed
                     of two C4-type zinc fingers; cl02596"
                     /db_xref="CDD:413390"
     Region          135..374
                     /region_name="NR_LBD_ROR_like"
                     /note="The ligand binding domain of Retinoid-related
                     orphan receptors, of the nuclear receptor superfamily;
                     cd06939"
                     /db_xref="CDD:132737"
     Site            order(151..153,183,186..187,189..190,193,227,230..231,
                     233..234,242..244,254,257,266,347)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:132737"
     Site            order(202,212,215..216,219..220,368..369,372..373)
                     /site_type="other"
                     /note="coactivator recognition site [polypeptide binding]"
                     /db_xref="CDD:132737"
     CDS             1..386
                     /gene="RORA"
                     /gene_synonym="IDDECA; NR1F1; ROR1; ROR2; ROR3; RORa1;
                     RORalpha; RZR-ALPHA; RZRA"
                     /coded_by="XM_047432928.1:2002..3162"
                     /db_xref="GeneID:6095"
                     /db_xref="HGNC:HGNC:10258"
                     /db_xref="MIM:600825"
ORIGIN      
        1 msrdavkfgr mskkqrdsly aevqkhrmqq qqrdhqqqpg eaepltptyn isangltelh
       61 ddlsnyidgh tpegskadsa vssfyldiqp spdqsgldin gikpepicdy tpasgffpyc
      121 sftngetspt vsmaelehla qniskshlet cqylreelqq itwqtflqee ienyqnkqre
      181 vmwqlcaiki teaiqyvvef akridgfmel cqndqivllk agslevvfir mcrafdsqnn
      241 tvyfdgkyas pdvfkslgce dfisfvfefg kslcsmhlte deialfsafv lmsadrswlq
      301 ekvkieklqq kiqlalqhvl qknhredgil tklickvstl ralcgrhtek lmafkaiypd
      361 ivrlhfpply kelftsefep amqidg
//
LOCUS       XP_047288885             386 aa            linear   PRI 05-AUG-2025
DEFINITION  nuclear receptor ROR-alpha isoform X4 [Homo sapiens].
ACCESSION   XP_047288885
VERSION     XP_047288885.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432929.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..386
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..386
                     /product="nuclear receptor ROR-alpha isoform X4"
                     /calculated_mol_wt=44160
     Region          <1..23
                     /region_name="NR_DBD_like"
                     /note="DNA-binding domain of nuclear receptors is composed
                     of two C4-type zinc fingers; cl02596"
                     /db_xref="CDD:413390"
     Region          135..374
                     /region_name="NR_LBD_ROR_like"
                     /note="The ligand binding domain of Retinoid-related
                     orphan receptors, of the nuclear receptor superfamily;
                     cd06939"
                     /db_xref="CDD:132737"
     Site            order(151..153,183,186..187,189..190,193,227,230..231,
                     233..234,242..244,254,257,266,347)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:132737"
     Site            order(202,212,215..216,219..220,368..369,372..373)
                     /site_type="other"
                     /note="coactivator recognition site [polypeptide binding]"
                     /db_xref="CDD:132737"
     CDS             1..386
                     /gene="RORA"
                     /gene_synonym="IDDECA; NR1F1; ROR1; ROR2; ROR3; RORa1;
                     RORalpha; RZR-ALPHA; RZRA"
                     /coded_by="XM_047432929.1:611..1771"
                     /db_xref="GeneID:6095"
                     /db_xref="HGNC:HGNC:10258"
                     /db_xref="MIM:600825"
ORIGIN      
        1 msrdavkfgr mskkqrdsly aevqkhrmqq qqrdhqqqpg eaepltptyn isangltelh
       61 ddlsnyidgh tpegskadsa vssfyldiqp spdqsgldin gikpepicdy tpasgffpyc
      121 sftngetspt vsmaelehla qniskshlet cqylreelqq itwqtflqee ienyqnkqre
      181 vmwqlcaiki teaiqyvvef akridgfmel cqndqivllk agslevvfir mcrafdsqnn
      241 tvyfdgkyas pdvfkslgce dfisfvfefg kslcsmhlte deialfsafv lmsadrswlq
      301 ekvkieklqq kiqlalqhvl qknhredgil tklickvstl ralcgrhtek lmafkaiypd
      361 ivrlhfpply kelftsefep amqidg
//
LOCUS       XP_047288886             386 aa            linear   PRI 05-AUG-2025
DEFINITION  nuclear receptor ROR-alpha isoform X4 [Homo sapiens].
ACCESSION   XP_047288886
VERSION     XP_047288886.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432930.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..386
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..386
                     /product="nuclear receptor ROR-alpha isoform X4"
                     /calculated_mol_wt=44160
     Region          <1..23
                     /region_name="NR_DBD_like"
                     /note="DNA-binding domain of nuclear receptors is composed
                     of two C4-type zinc fingers; cl02596"
                     /db_xref="CDD:413390"
     Region          135..374
                     /region_name="NR_LBD_ROR_like"
                     /note="The ligand binding domain of Retinoid-related
                     orphan receptors, of the nuclear receptor superfamily;
                     cd06939"
                     /db_xref="CDD:132737"
     Site            order(151..153,183,186..187,189..190,193,227,230..231,
                     233..234,242..244,254,257,266,347)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:132737"
     Site            order(202,212,215..216,219..220,368..369,372..373)
                     /site_type="other"
                     /note="coactivator recognition site [polypeptide binding]"
                     /db_xref="CDD:132737"
     CDS             1..386
                     /gene="RORA"
                     /gene_synonym="IDDECA; NR1F1; ROR1; ROR2; ROR3; RORa1;
                     RORalpha; RZR-ALPHA; RZRA"
                     /coded_by="XM_047432930.1:502..1662"
                     /db_xref="GeneID:6095"
                     /db_xref="HGNC:HGNC:10258"
                     /db_xref="MIM:600825"
ORIGIN      
        1 msrdavkfgr mskkqrdsly aevqkhrmqq qqrdhqqqpg eaepltptyn isangltelh
       61 ddlsnyidgh tpegskadsa vssfyldiqp spdqsgldin gikpepicdy tpasgffpyc
      121 sftngetspt vsmaelehla qniskshlet cqylreelqq itwqtflqee ienyqnkqre
      181 vmwqlcaiki teaiqyvvef akridgfmel cqndqivllk agslevvfir mcrafdsqnn
      241 tvyfdgkyas pdvfkslgce dfisfvfefg kslcsmhlte deialfsafv lmsadrswlq
      301 ekvkieklqq kiqlalqhvl qknhredgil tklickvstl ralcgrhtek lmafkaiypd
      361 ivrlhfpply kelftsefep amqidg
//
LOCUS       XP_011520181             376 aa            linear   PRI 05-AUG-2025
DEFINITION  nuclear receptor ROR-alpha isoform X5 [Homo sapiens].
ACCESSION   XP_011520181
VERSION     XP_011520181.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521879.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..376
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..376
                     /product="nuclear receptor ROR-alpha isoform X5"
                     /calculated_mol_wt=43012
     Region          125..364
                     /region_name="NR_LBD_ROR_like"
                     /note="The ligand binding domain of Retinoid-related
                     orphan receptors, of the nuclear receptor superfamily;
                     cd06939"
                     /db_xref="CDD:132737"
     Site            order(141..143,173,176..177,179..180,183,217,220..221,
                     223..224,232..234,244,247,256,337)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:132737"
     Site            order(192,202,205..206,209..210,358..359,362..363)
                     /site_type="other"
                     /note="coactivator recognition site [polypeptide binding]"
                     /db_xref="CDD:132737"
     CDS             1..376
                     /gene="RORA"
                     /gene_synonym="IDDECA; NR1F1; ROR1; ROR2; ROR3; RORa1;
                     RORalpha; RZR-ALPHA; RZRA"
                     /coded_by="XM_011521879.4:86..1216"
                     /db_xref="GeneID:6095"
                     /db_xref="HGNC:HGNC:10258"
                     /db_xref="MIM:600825"
ORIGIN      
        1 mskkqrdsly aevqkhrmqq qqrdhqqqpg eaepltptyn isangltelh ddlsnyidgh
       61 tpegskadsa vssfyldiqp spdqsgldin gikpepicdy tpasgffpyc sftngetspt
      121 vsmaelehla qniskshlet cqylreelqq itwqtflqee ienyqnkqre vmwqlcaiki
      181 teaiqyvvef akridgfmel cqndqivllk agslevvfir mcrafdsqnn tvyfdgkyas
      241 pdvfkslgce dfisfvfefg kslcsmhlte deialfsafv lmsadrswlq ekvkieklqq
      301 kiqlalqhvl qknhredgil tklickvstl ralcgrhtek lmafkaiypd ivrlhfpply
      361 kelftsefep amqidg
//
LOCUS       XP_016877957            4866 aa            linear   PRI 05-AUG-2025
DEFINITION  ryanodine receptor 3 isoform X1 [Homo sapiens].
ACCESSION   XP_016877957
VERSION     XP_016877957.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022468.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4866
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4866
                     /product="ryanodine receptor 3 isoform X1"
                     /calculated_mol_wt=551451
     Region          14..212
                     /region_name="Ins145_P3_rec"
                     /note="Inositol 1,4,5-trisphosphate/ryanodine receptor;
                     pfam08709"
                     /db_xref="CDD:462572"
     Region          216..405
                     /region_name="beta-trefoil_MIR_RyR3"
                     /note="MIR domain, beta-trefoil fold, found in ryanodine
                     receptor 3 (RyR3) and similar proteins; cd23292"
                     /db_xref="CDD:467763"
     Site            391
                     /site_type="other"
                     /note="putative homotetramer interface [polypeptide
                     binding]"
                     /db_xref="CDD:467763"
     Region          442..621
                     /region_name="RYDR_ITPR"
                     /note="RIH domain; pfam01365"
                     /db_xref="CDD:460175"
     Region          641..792
                     /region_name="SPRY1_RyR"
                     /note="SPRY domain 1 (SPRY1) of ryanodine receptor (RyR);
                     cd12877"
                     /db_xref="CDD:240457"
     Region          849..937
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          963..1052
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          1072..1204
                     /region_name="SPRY2_RyR"
                     /note="SPRY domain 2 (SPRY2) of ryanodine receptor (RyR);
                     cd12878"
                     /db_xref="CDD:240458"
     Region          1324..1462
                     /region_name="SPRY3_RyR"
                     /note="SPRY domain 3 (SPRY3) of ryanodine receptor (RyR);
                     cd12879"
                     /db_xref="CDD:293937"
     Region          2023..2233
                     /region_name="RYDR_ITPR"
                     /note="RIH domain; pfam01365"
                     /db_xref="CDD:460175"
     Region          2598..2687
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          2716..2795
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          3723..3840
                     /region_name="RIH_assoc"
                     /note="RyR and IP3R Homology associated; pfam08454"
                     /db_xref="CDD:462482"
     Region          3924..3979
                     /region_name="EF-hand_7"
                     /note="EF-hand domain pair; pfam13499"
                     /db_xref="CDD:463900"
     Region          4230..4500
                     /region_name="RR_TM4-6"
                     /note="Ryanodine Receptor TM 4-6; pfam06459"
                     /db_xref="CDD:461918"
     Region          <4617..4777
                     /region_name="Ion_trans"
                     /note="Ion transport protein; pfam00520"
                     /db_xref="CDD:459842"
     CDS             1..4866
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /coded_by="XM_017022468.2:80..14680"
                     /db_xref="GeneID:6263"
                     /db_xref="HGNC:HGNC:10485"
                     /db_xref="MIM:180903"
ORIGIN      
        1 maeggegged eiqflrtede vvlqciatih keqrkfclaa eglgnrlcfl eptseakyip
       61 pdlcvcnfvl eqslsvralq emlantgeng gegaaqgggh rtllyghavl lrhsfsgmyl
      121 tclttsrsqt dklafdvglr ehatgeacww tihpaskqrs egekvrigdd lilvsvsser
      181 ylhlsvsngn iqvdasfmqt lwnvhptcsg ssieegyllg ghvvrlfhgh decltipstd
      241 qndsqhrrif yeaggagtra rslwrveplr iswsgsnirw gqafrlrhlt tghylalted
      301 qglilqdrak sdtkstafsf raskelkekl dsshkrdieg mgvpeikygd svcfvqhias
      361 glwvtykaqd aktsrlgplk rkvilhqegh mddgltlqrc qreesqaari irnttalfsq
      421 fvsgnnrtaa pitlpieevl qtlqdliayf qppeeemrhe dkqnklrslk nrqnlfkeeg
      481 mlalvlncid rlnvynsvah fagiareesg mawkeilnll ykllaalirg nrnncaqfsn
      541 nldwliskld rlesssgile vlhciltesp ealnliaegh iksiislldk hgrnhkvldi
      601 lcslclcngv avranqnlic dnllprrnll lqtrlindvt sirpniflgv aegsaqykkw
      661 yfeliidqvd pfltaepthl rvgwasssgy apypgggegw ggngvgddly sygfdglhlw
      721 sgripravas inqhllrsdd vvsccldlgv psisfringq pvqgmfenfn tdglffpvms
      781 fsagvkvrfl mggrhgefkf lppsgyapcy eallpkekmr lepvkeykrd adgirdllgt
      841 tqflsqasfi pcpvdtsqvi lpphlekird rlaenihelw gmnkielgwt fgkirddnkr
      901 qhpclvefsk lpeteknynl qmstetlktl lalgchiahv npaaeedlkk vklpknymms
      961 ngykpapldl sdvkllppqe ilvdklaena hnvwakdrik qgwtygiqqd lknkrnprlv
     1021 pyalldertk ksnrdslrea vrtfvgygyn iepsdqelad savekvsidk irffrversy
     1081 avrsgkwyfe fevvtggdmr vgwarpgcrp dvelgaddqa fvfegnrgqr whqgsgyfgr
     1141 twqpgdvvgc minlddasmi ftlngellit nkgselafad yeiengfvpi cclglsqigr
     1201 mnlgtdastf kfytmcglqe gfepfavnmn rdvamwfskr lptfvnvpkd hphievmrid
     1261 gtmdsppclk vthktfgtqn snadmiycrl smpvechssf shspcldsea fqkrkqmqei
     1321 lshtttqcyy airifagqdp scvwvgwvtp dyhlysekfd lnknctvtvt lgdergrvhe
     1381 svkrsncymv wggdivassq rsnrsnvdle igclvdlamg mlsfsangke lgtcyqvepn
     1441 tkvfpavflq ptstslfqfe lgklknampl saaifrseek npvpqcpprl dvqtiqpvlw
     1501 srmpnsflkv etervserhg wvvqcleplq mmalhipeen rcvdilelce qedlmrfhyh
     1561 tlrlysavca lgnsrvayal cshvdlsqlf yaidnkylpg llrsgfydll isihlasake
     1621 rklmmkneyi ipitsttrni rlfpdeskrh glpgvglrtc lkpgfrfstp cfvvtgedhq
     1681 kqspeiples lrtkalsmlt eavqcsgahi rdpvggsvef qfvpvlklig tllvmgvfdd
     1741 ddvrqillli dpsvfgehsa gteegaekee vtqveekave agekagkeap vkgllqtrlp
     1801 esvklqmcel lsylcdcelq hrveaivafg diyvsklqan qkfrynelmq alnmsaalta
     1861 rktkefrspp qeqinmllnf qlgencpcpe eireelydfh edlllhcgvp leeeeeeeed
     1921 tswtgklcal vykikgppkp ekeqpteeee rcpttlkeli sqtmicwaqe dqiqdselvr
     1981 mmfnllrrqy dsigellqal rktytishts vsdtinllaa lgqirsllsv rmgkeeellm
     2041 inglgdimnn kvfyqhpnlm rvlgmhetvm evmvnvlgte ksqiafpkmv asccrflcyf
     2101 crisrqnqka mfehlsylle nssvglasps mrgstpldva assvmdnnel alsleepdle
     2161 kvvtylagcg lqscpmllak gypdvgwnpi egerylsflr favfvnsesv eenasvvvkl
     2221 lirrpecfgp alrgeggngl laamqgaiki senpaldlps qgykrevstg ddeeeeeivh
     2281 mgnaimsfys alidllgrca pemhliqtgk geairirsil rslvptedlv giisiplklp
     2341 slnkdgsvse pdmaanfcpd hkapmvlfld rvygikdqtf llhllevgfl pdlrasasld
     2401 tvslstteaa lalnryicsa vlplltrcap lfagtehcts lidstlqtiy rlskgrsltk
     2461 aqrdtieecl laicnhlrps mlqqllrrlv fdvpqlneyc kmplklltnh yeqcwkyycl
     2521 psgwgsygla veeelhltek lfwgifdsls hkkydpdlfr malpclsaia galppdyldt
     2581 ritatlekqi svdadgnfdp kpintmnfsl pekleyivtk yaehshdkwa cdksqsgwky
     2641 gisldenvkt hplirpfktl tekekeiyrw pareslktml avgwtvertk egealvqqre
     2701 neklrsvsqa nqgnsyspap ldlsnvvlsr elqgmvevva enyhniwakk kkleleskgg
     2761 gshpllvpyd tltakekfkd rekaqdlfkf lqvngiivsr gmkdmeldas smekrfaykf
     2821 lkkilkyvds aqefiahlea ivssgkteks prdqeikffa kvllplvdqy ftshclyfls
     2881 splkplsssg yashkekemv aglfcklaal vrhrislfgs dsttmvsclh ilaqtldtrt
     2941 vmksgselvk aglraffena aedlektsen lklgkfthsr tqikgvsqni nyttvallpi
     3001 ltsifehvtq hqfgmdlllg dvqiscyhil cslyslgtgk niyverqrpa lgeclaslaa
     3061 aipvaflept lnrynplsvf ntktprersi lgmpdtvedm cpdipqlegl mkeindlaes
     3121 garytemphv ievilpmlcn ylsywwergp enlppstgpc ctkvtsehls lilgnilkii
     3181 nnnlgideas wmkriavyaq piiskarpdl lrshfiptle klkkkavktv qeeeqlkadg
     3241 kgdtqeaell ildefavlcr dlyafypmli ryvdnnrsnw lkspdadsdq lfrmvaevfi
     3301 lwckshnfkr eeqnfviqne innlafltgd skskmsksgg qdqerkktkr rgdlysiqts
     3361 livaalkkml piglnmctpg dqelislaks ryshrdtdee vrehlrnnlh lqeksddpav
     3421 kwqlnlykdv lkseepfnpe ktvervqris aavfhleqve qplrskkavw hkllskqrkr
     3481 avvacfrmap lynlprhkin nfflstfqqv wlekvnektq ydrlipilmk spkveeeeee
     3541 etekqpdplh qiilyfsrna lterskledd plytsyssmm akscqsgede eededkektf
     3601 eekemekqkt lyqqarlher gaaemvlqmi saskgemspm vvetlklgia ilnggnagvq
     3661 qkmldylkek kdagffqsls glmqscsvld lnaferqnka eglgmvteeg tlivrergek
     3721 vlqndeftrd lfrflqllce ghnsdfqnfl rtqmgntttv nviistvdyl lrlqesisdf
     3781 ywyysgkdii desgqhnfsk alavtkqifn slteyiqgpc ignqqslahs rlwdavvgfl
     3841 hvfanmqmkl sqdssqiell kelldllqdm vvmllslleg nvvngtigkq mvdtlvesst
     3901 nvemilkffd mflklkdlts sdtfkeydpd gkgiiskkef qkamegqkqy tqseidflls
     3961 caeadendmf nyvdfvdrfh epakdigfnv avlltnlseh mpndsrlkcl ldpaesvlny
     4021 fepylgriei mggakkierv yfeisessrt qwekpqvkes krqfifdvvn eggeqekmel
     4081 fvnfcedtif emqlasqise sdsadrpeee eededssyvl eiageeeedg slepasafam
     4141 acasvkrnvt dflkratlkn lrkqyrnvkk mtakelvkvl fsffwmlfvg lfqllftilg
     4201 gifqilwstv fggglvegak nirvtkilgd mpdptqfgih ddtmeaerae vmepgittel
     4261 vhfikgekgd tdimsdlfgl hpkkegslkh gpevglgdls eiigkdeppt lestvqkkrk
     4321 aqaaemkaan eaegkvesek admedgeked kdkeeeqaey lwtevtkkkk rrcgqkvekp
     4381 eaftanffkg leiyqtkllh ylarnfynlr flalfvafai nfillfykvt eepleeeted
     4441 vanlwnsfnd eeeeeamvff vlqestgyma ptlralaiih tiislvcvvg yyclkvplvv
     4501 fkrekeiark lefdglyite qpseddikgq wdrlvintps fpnnywdkfv krkvinkygd
     4561 lygaeriael lgldknaldf spveetkaea aslvswlssi dmkyhiwklg vvftdnsfly
     4621 lawyttmsvl ghynnfffaa hlldiamgfk tlrtilssvt hngkqlvltv gllavvvyly
     4681 tvvafnffrk fynkseddde pdmkcddmmt cylfhmyvgv ragggigdei edpagdpyem
     4741 yrivfditff ffvivillai iqgliidafg elrdqqeqvr edmetkcfic gigndyfdtt
     4801 phgfethtlq ehnlanylff lmylinkdet ehtgqesyvw kmyqercwdf fpagdcfrkq
     4861 yedqlg
//
LOCUS       XP_016877958            4865 aa            linear   PRI 05-AUG-2025
DEFINITION  ryanodine receptor 3 isoform X2 [Homo sapiens].
ACCESSION   XP_016877958
VERSION     XP_016877958.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022469.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4865
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4865
                     /product="ryanodine receptor 3 isoform X2"
                     /calculated_mol_wt=551364
     Region          14..212
                     /region_name="Ins145_P3_rec"
                     /note="Inositol 1,4,5-trisphosphate/ryanodine receptor;
                     pfam08709"
                     /db_xref="CDD:462572"
     Region          216..405
                     /region_name="beta-trefoil_MIR_RyR3"
                     /note="MIR domain, beta-trefoil fold, found in ryanodine
                     receptor 3 (RyR3) and similar proteins; cd23292"
                     /db_xref="CDD:467763"
     Site            391
                     /site_type="other"
                     /note="putative homotetramer interface [polypeptide
                     binding]"
                     /db_xref="CDD:467763"
     Region          442..621
                     /region_name="RYDR_ITPR"
                     /note="RIH domain; pfam01365"
                     /db_xref="CDD:460175"
     Region          641..792
                     /region_name="SPRY1_RyR"
                     /note="SPRY domain 1 (SPRY1) of ryanodine receptor (RyR);
                     cd12877"
                     /db_xref="CDD:240457"
     Region          849..937
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          963..1052
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          1072..1204
                     /region_name="SPRY2_RyR"
                     /note="SPRY domain 2 (SPRY2) of ryanodine receptor (RyR);
                     cd12878"
                     /db_xref="CDD:240458"
     Region          1324..1462
                     /region_name="SPRY3_RyR"
                     /note="SPRY domain 3 (SPRY3) of ryanodine receptor (RyR);
                     cd12879"
                     /db_xref="CDD:293937"
     Region          2023..2233
                     /region_name="RYDR_ITPR"
                     /note="RIH domain; pfam01365"
                     /db_xref="CDD:460175"
     Region          2597..2686
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          2715..2794
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          3722..3839
                     /region_name="RIH_assoc"
                     /note="RyR and IP3R Homology associated; pfam08454"
                     /db_xref="CDD:462482"
     Region          3923..3978
                     /region_name="EF-hand_7"
                     /note="EF-hand domain pair; pfam13499"
                     /db_xref="CDD:463900"
     Region          4229..4499
                     /region_name="RR_TM4-6"
                     /note="Ryanodine Receptor TM 4-6; pfam06459"
                     /db_xref="CDD:461918"
     Region          <4616..4776
                     /region_name="Ion_trans"
                     /note="Ion transport protein; pfam00520"
                     /db_xref="CDD:459842"
     CDS             1..4865
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /coded_by="XM_017022469.2:80..14677"
                     /db_xref="GeneID:6263"
                     /db_xref="HGNC:HGNC:10485"
                     /db_xref="MIM:180903"
ORIGIN      
        1 maeggegged eiqflrtede vvlqciatih keqrkfclaa eglgnrlcfl eptseakyip
       61 pdlcvcnfvl eqslsvralq emlantgeng gegaaqgggh rtllyghavl lrhsfsgmyl
      121 tclttsrsqt dklafdvglr ehatgeacww tihpaskqrs egekvrigdd lilvsvsser
      181 ylhlsvsngn iqvdasfmqt lwnvhptcsg ssieegyllg ghvvrlfhgh decltipstd
      241 qndsqhrrif yeaggagtra rslwrveplr iswsgsnirw gqafrlrhlt tghylalted
      301 qglilqdrak sdtkstafsf raskelkekl dsshkrdieg mgvpeikygd svcfvqhias
      361 glwvtykaqd aktsrlgplk rkvilhqegh mddgltlqrc qreesqaari irnttalfsq
      421 fvsgnnrtaa pitlpieevl qtlqdliayf qppeeemrhe dkqnklrslk nrqnlfkeeg
      481 mlalvlncid rlnvynsvah fagiareesg mawkeilnll ykllaalirg nrnncaqfsn
      541 nldwliskld rlesssgile vlhciltesp ealnliaegh iksiislldk hgrnhkvldi
      601 lcslclcngv avranqnlic dnllprrnll lqtrlindvt sirpniflgv aegsaqykkw
      661 yfeliidqvd pfltaepthl rvgwasssgy apypgggegw ggngvgddly sygfdglhlw
      721 sgripravas inqhllrsdd vvsccldlgv psisfringq pvqgmfenfn tdglffpvms
      781 fsagvkvrfl mggrhgefkf lppsgyapcy eallpkekmr lepvkeykrd adgirdllgt
      841 tqflsqasfi pcpvdtsqvi lpphlekird rlaenihelw gmnkielgwt fgkirddnkr
      901 qhpclvefsk lpeteknynl qmstetlktl lalgchiahv npaaeedlkk vklpknymms
      961 ngykpapldl sdvkllppqe ilvdklaena hnvwakdrik qgwtygiqqd lknkrnprlv
     1021 pyalldertk ksnrdslrea vrtfvgygyn iepsdqelad savekvsidk irffrversy
     1081 avrsgkwyfe fevvtggdmr vgwarpgcrp dvelgaddqa fvfegnrgqr whqgsgyfgr
     1141 twqpgdvvgc minlddasmi ftlngellit nkgselafad yeiengfvpi cclglsqigr
     1201 mnlgtdastf kfytmcglqe gfepfavnmn rdvamwfskr lptfvnvpkd hphievmrid
     1261 gtmdsppclk vthktfgtqn snadmiycrl smpvechssf shspcldsea fqkrkqmqei
     1321 lshtttqcyy airifagqdp scvwvgwvtp dyhlysekfd lnknctvtvt lgdergrvhe
     1381 svkrsncymv wggdivassq rsnrsnvdle igclvdlamg mlsfsangke lgtcyqvepn
     1441 tkvfpavflq ptstslfqfe lgklknampl saaifrseek npvpqcpprl dvqtiqpvlw
     1501 srmpnsflkv etervserhg wvvqcleplq mmalhipeen rcvdilelce qedlmrfhyh
     1561 tlrlysavca lgnsrvayal cshvdlsqlf yaidnkylpg llrsgfydll isihlasake
     1621 rklmmkneyi ipitsttrni rlfpdeskrh glpgvglrtc lkpgfrfstp cfvvtgedhq
     1681 kqspeiples lrtkalsmlt eavqcsgahi rdpvggsvef qfvpvlklig tllvmgvfdd
     1741 ddvrqillli dpsvfgehsa gteegaekee vtqveekave agekagkeap vkgllqtrlp
     1801 esvklqmcel lsylcdcelq hrveaivafg diyvsklqan qkfrynelmq alnmsaalta
     1861 rktkefrspp qeqinmllnf qlgencpcpe eireelydfh edlllhcgvp leeeeeeeed
     1921 tswtgklcal vykikgppkp ekeqpteeee rcpttlkeli sqtmicwaqe dqiqdselvr
     1981 mmfnllrrqy dsigellqal rktytishts vsdtinllaa lgqirsllsv rmgkeeellm
     2041 inglgdimnn kvfyqhpnlm rvlgmhetvm evmvnvlgte ksqiafpkmv asccrflcyf
     2101 crisrqnqka mfehlsylle nssvglasps mrgstpldva assvmdnnel alsleepdle
     2161 kvvtylagcg lqscpmllak gypdvgwnpi egerylsflr favfvnsesv eenasvvvkl
     2221 lirrpecfgp alrgeggngl laamqgaiki senpaldlps qgykrevtgd deeeeeivhm
     2281 gnaimsfysa lidllgrcap emhliqtgkg eairirsilr slvptedlvg iisiplklps
     2341 lnkdgsvsep dmaanfcpdh kapmvlfldr vygikdqtfl lhllevgflp dlrasasldt
     2401 vslstteaal alnryicsav lplltrcapl fagtehctsl idstlqtiyr lskgrsltka
     2461 qrdtieecll aicnhlrpsm lqqllrrlvf dvpqlneyck mplklltnhy eqcwkyyclp
     2521 sgwgsyglav eeelhltekl fwgifdslsh kkydpdlfrm alpclsaiag alppdyldtr
     2581 itatlekqis vdadgnfdpk pintmnfslp ekleyivtky aehshdkwac dksqsgwkyg
     2641 isldenvkth plirpfktlt ekekeiyrwp areslktmla vgwtvertke gealvqqren
     2701 eklrsvsqan qgnsyspapl dlsnvvlsre lqgmvevvae nyhniwakkk kleleskggg
     2761 shpllvpydt ltakekfkdr ekaqdlfkfl qvngiivsrg mkdmeldass mekrfaykfl
     2821 kkilkyvdsa qefiahleai vssgkteksp rdqeikffak vllplvdqyf tshclyflss
     2881 plkplsssgy ashkekemva glfcklaalv rhrislfgsd sttmvsclhi laqtldtrtv
     2941 mksgselvka glraffenaa edlektsenl klgkfthsrt qikgvsqnin yttvallpil
     3001 tsifehvtqh qfgmdlllgd vqiscyhilc slyslgtgkn iyverqrpal geclaslaaa
     3061 ipvafleptl nrynplsvfn tktprersil gmpdtvedmc pdipqleglm keindlaesg
     3121 arytemphvi evilpmlcny lsywwergpe nlppstgpcc tkvtsehlsl ilgnilkiin
     3181 nnlgideasw mkriavyaqp iiskarpdll rshfiptlek lkkkavktvq eeeqlkadgk
     3241 gdtqeaelli ldefavlcrd lyafypmlir yvdnnrsnwl kspdadsdql frmvaevfil
     3301 wckshnfkre eqnfviqnei nnlafltgds kskmsksggq dqerkktkrr gdlysiqtsl
     3361 ivaalkkmlp iglnmctpgd qelislaksr yshrdtdeev rehlrnnlhl qeksddpavk
     3421 wqlnlykdvl kseepfnpek tvervqrisa avfhleqveq plrskkavwh kllskqrkra
     3481 vvacfrmapl ynlprhkinn fflstfqqvw lekvnektqy drlipilmks pkveeeeeee
     3541 tekqpdplhq iilyfsrnal terskleddp lytsyssmma kscqsgedee ededkektfe
     3601 ekemekqktl yqqarlherg aaemvlqmis askgemspmv vetlklgiai lnggnagvqq
     3661 kmldylkekk dagffqslsg lmqscsvldl naferqnkae glgmvteegt livrergekv
     3721 lqndeftrdl frflqllceg hnsdfqnflr tqmgntttvn viistvdyll rlqesisdfy
     3781 wyysgkdiid esgqhnfska lavtkqifns lteyiqgpci gnqqslahsr lwdavvgflh
     3841 vfanmqmkls qdssqiellk elldllqdmv vmllsllegn vvngtigkqm vdtlvesstn
     3901 vemilkffdm flklkdltss dtfkeydpdg kgiiskkefq kamegqkqyt qseidfllsc
     3961 aeadendmfn yvdfvdrfhe pakdigfnva vlltnlsehm pndsrlkcll dpaesvlnyf
     4021 epylgrieim ggakkiervy feisessrtq wekpqvkesk rqfifdvvne ggeqekmelf
     4081 vnfcedtife mqlasqises dsadrpeeee ededssyvle iageeeedgs lepasafama
     4141 casvkrnvtd flkratlknl rkqyrnvkkm takelvkvlf sffwmlfvgl fqllftilgg
     4201 ifqilwstvf ggglvegakn irvtkilgdm pdptqfgihd dtmeaeraev mepgittelv
     4261 hfikgekgdt dimsdlfglh pkkegslkhg pevglgdlse iigkdepptl estvqkkrka
     4321 qaaemkaane aegkveseka dmedgekedk dkeeeqaeyl wtevtkkkkr rcgqkvekpe
     4381 aftanffkgl eiyqtkllhy larnfynlrf lalfvafain fillfykvte epleeetedv
     4441 anlwnsfnde eeeeamvffv lqestgymap tlralaiiht iislvcvvgy yclkvplvvf
     4501 krekeiarkl efdglyiteq pseddikgqw drlvintpsf pnnywdkfvk rkvinkygdl
     4561 ygaeriaell gldknaldfs pveetkaeaa slvswlssid mkyhiwklgv vftdnsflyl
     4621 awyttmsvlg hynnfffaah lldiamgfkt lrtilssvth ngkqlvltvg llavvvylyt
     4681 vvafnffrkf ynksedddep dmkcddmmtc ylfhmyvgvr agggigdeie dpagdpyemy
     4741 rivfditfff fvivillaii qgliidafge lrdqqeqvre dmetkcficg igndyfdttp
     4801 hgfethtlqe hnlanylffl mylinkdete htgqesyvwk myqercwdff pagdcfrkqy
     4861 edqlg
//
LOCUS       XP_016877959            4865 aa            linear   PRI 05-AUG-2025
DEFINITION  ryanodine receptor 3 isoform X3 [Homo sapiens].
ACCESSION   XP_016877959
VERSION     XP_016877959.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022470.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4865
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4865
                     /product="ryanodine receptor 3 isoform X3"
                     /calculated_mol_wt=551539
     Region          17..211
                     /region_name="Ins145_P3_rec"
                     /note="Inositol 1,4,5-trisphosphate/ryanodine receptor;
                     pfam08709"
                     /db_xref="CDD:462572"
     Region          215..404
                     /region_name="beta-trefoil_MIR_RyR3"
                     /note="MIR domain, beta-trefoil fold, found in ryanodine
                     receptor 3 (RyR3) and similar proteins; cd23292"
                     /db_xref="CDD:467763"
     Site            390
                     /site_type="other"
                     /note="putative homotetramer interface [polypeptide
                     binding]"
                     /db_xref="CDD:467763"
     Region          441..620
                     /region_name="RYDR_ITPR"
                     /note="RIH domain; pfam01365"
                     /db_xref="CDD:460175"
     Region          640..791
                     /region_name="SPRY1_RyR"
                     /note="SPRY domain 1 (SPRY1) of ryanodine receptor (RyR);
                     cd12877"
                     /db_xref="CDD:240457"
     Region          848..936
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          962..1051
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          1071..1203
                     /region_name="SPRY2_RyR"
                     /note="SPRY domain 2 (SPRY2) of ryanodine receptor (RyR);
                     cd12878"
                     /db_xref="CDD:240458"
     Region          1323..1461
                     /region_name="SPRY3_RyR"
                     /note="SPRY domain 3 (SPRY3) of ryanodine receptor (RyR);
                     cd12879"
                     /db_xref="CDD:293937"
     Region          2022..2232
                     /region_name="RYDR_ITPR"
                     /note="RIH domain; pfam01365"
                     /db_xref="CDD:460175"
     Region          2597..2686
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          2715..2794
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          3722..3839
                     /region_name="RIH_assoc"
                     /note="RyR and IP3R Homology associated; pfam08454"
                     /db_xref="CDD:462482"
     Region          3923..3978
                     /region_name="EF-hand_7"
                     /note="EF-hand domain pair; pfam13499"
                     /db_xref="CDD:463900"
     Region          4229..4499
                     /region_name="RR_TM4-6"
                     /note="Ryanodine Receptor TM 4-6; pfam06459"
                     /db_xref="CDD:461918"
     Region          <4616..4776
                     /region_name="Ion_trans"
                     /note="Ion transport protein; pfam00520"
                     /db_xref="CDD:459842"
     CDS             1..4865
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /coded_by="XM_017022470.3:3503..18100"
                     /db_xref="GeneID:6263"
                     /db_xref="HGNC:HGNC:10485"
                     /db_xref="MIM:180903"
ORIGIN      
        1 mrnlkdfvse pglykeedev vlqciatihk eqrkfclaae glgnrlcfle ptseakyipp
       61 dlcvcnfvle qslsvralqe mlantgengg egaaqggghr tllyghavll rhsfsgmylt
      121 clttsrsqtd klafdvglre hatgeacwwt ihpaskqrse gekvrigddl ilvsvssery
      181 lhlsvsngni qvdasfmqtl wnvhptcsgs sieegyllgg hvvrlfhghd ecltipstdq
      241 ndsqhrrify eaggagtrar slwrveplri swsgsnirwg qafrlrhltt ghylaltedq
      301 glilqdraks dtkstafsfr askelkekld sshkrdiegm gvpeikygds vcfvqhiasg
      361 lwvtykaqda ktsrlgplkr kvilhqeghm ddgltlqrcq reesqaarii rnttalfsqf
      421 vsgnnrtaap itlpieevlq tlqdliayfq ppeeemrhed kqnklrslkn rqnlfkeegm
      481 lalvlncidr lnvynsvahf agiareesgm awkeilnlly kllaalirgn rnncaqfsnn
      541 ldwliskldr lesssgilev lhciltespe alnliaeghi ksiislldkh grnhkvldil
      601 cslclcngva vranqnlicd nllprrnlll qtrlindvts irpniflgva egsaqykkwy
      661 feliidqvdp fltaepthlr vgwasssgya pypgggegwg gngvgddlys ygfdglhlws
      721 gripravasi nqhllrsddv vsccldlgvp sisfringqp vqgmfenfnt dglffpvmsf
      781 sagvkvrflm ggrhgefkfl ppsgyapcye allpkekmrl epvkeykrda dgirdllgtt
      841 qflsqasfip cpvdtsqvil pphlekirdr laenihelwg mnkielgwtf gkirddnkrq
      901 hpclvefskl peteknynlq mstetlktll algchiahvn paaeedlkkv klpknymmsn
      961 gykpapldls dvkllppqei lvdklaenah nvwakdrikq gwtygiqqdl knkrnprlvp
     1021 yalldertkk snrdslreav rtfvgygyni epsdqelads avekvsidki rffrversya
     1081 vrsgkwyfef evvtggdmrv gwarpgcrpd velgaddqaf vfegnrgqrw hqgsgyfgrt
     1141 wqpgdvvgcm inlddasmif tlngellitn kgselafady eiengfvpic clglsqigrm
     1201 nlgtdastfk fytmcglqeg fepfavnmnr dvamwfskrl ptfvnvpkdh phievmridg
     1261 tmdsppclkv thktfgtqns nadmiycrls mpvechssfs hspcldseaf qkrkqmqeil
     1321 shtttqcyya irifagqdps cvwvgwvtpd yhlysekfdl nknctvtvtl gdergrvhes
     1381 vkrsncymvw ggdivassqr snrsnvdlei gclvdlamgm lsfsangkel gtcyqvepnt
     1441 kvfpavflqp tstslfqfel gklknampls aaifrseekn pvpqcpprld vqtiqpvlws
     1501 rmpnsflkve tervserhgw vvqcleplqm malhipeenr cvdilelceq edlmrfhyht
     1561 lrlysavcal gnsrvayalc shvdlsqlfy aidnkylpgl lrsgfydlli sihlasaker
     1621 klmmkneyii pitsttrnir lfpdeskrhg lpgvglrtcl kpgfrfstpc fvvtgedhqk
     1681 qspeiplesl rtkalsmlte avqcsgahir dpvggsvefq fvpvlkligt llvmgvfddd
     1741 dvrqilllid psvfgehsag teegaekeev tqveekavea gekagkeapv kgllqtrlpe
     1801 svklqmcell sylcdcelqh rveaivafgd iyvsklqanq kfrynelmqa lnmsaaltar
     1861 ktkefrsppq eqinmllnfq lgencpcpee ireelydfhe dlllhcgvpl eeeeeeeedt
     1921 swtgklcalv ykikgppkpe keqpteeeer cpttlkelis qtmicwaqed qiqdselvrm
     1981 mfnllrrqyd sigellqalr ktytishtsv sdtinllaal gqirsllsvr mgkeeellmi
     2041 nglgdimnnk vfyqhpnlmr vlgmhetvme vmvnvlgtek sqiafpkmva sccrflcyfc
     2101 risrqnqkam fehlsyllen ssvglaspsm rgstpldvaa ssvmdnnela lsleepdlek
     2161 vvtylagcgl qscpmllakg ypdvgwnpie gerylsflrf avfvnsesve enasvvvkll
     2221 irrpecfgpa lrgeggngll aamqgaikis enpaldlpsq gykrevstgd deeeeeivhm
     2281 gnaimsfysa lidllgrcap emhliqtgkg eairirsilr slvptedlvg iisiplklps
     2341 lnkdgsvsep dmaanfcpdh kapmvlfldr vygikdqtfl lhllevgflp dlrasasldt
     2401 vslstteaal alnryicsav lplltrcapl fagtehctsl idstlqtiyr lskgrsltka
     2461 qrdtieecll aicnhlrpsm lqqllrrlvf dvpqlneyck mplklltnhy eqcwkyyclp
     2521 sgwgsyglav eeelhltekl fwgifdslsh kkydpdlfrm alpclsaiag alppdyldtr
     2581 itatlekqis vdadgnfdpk pintmnfslp ekleyivtky aehshdkwac dksqsgwkyg
     2641 isldenvkth plirpfktlt ekekeiyrwp areslktmla vgwtvertke gealvqqren
     2701 eklrsvsqan qgnsyspapl dlsnvvlsre lqgmvevvae nyhniwakkk kleleskggg
     2761 shpllvpydt ltakekfkdr ekaqdlfkfl qvngiivsrg mkdmeldass mekrfaykfl
     2821 kkilkyvdsa qefiahleai vssgkteksp rdqeikffak vllplvdqyf tshclyflss
     2881 plkplsssgy ashkekemva glfcklaalv rhrislfgsd sttmvsclhi laqtldtrtv
     2941 mksgselvka glraffenaa edlektsenl klgkfthsrt qikgvsqnin yttvallpil
     3001 tsifehvtqh qfgmdlllgd vqiscyhilc slyslgtgkn iyverqrpal geclaslaaa
     3061 ipvafleptl nrynplsvfn tktprersil gmpdtvedmc pdipqleglm keindlaesg
     3121 arytemphvi evilpmlcny lsywwergpe nlppstgpcc tkvtsehlsl ilgnilkiin
     3181 nnlgideasw mkriavyaqp iiskarpdll rshfiptlek lkkkavktvq eeeqlkadgk
     3241 gdtqeaelli ldefavlcrd lyafypmlir yvdnnrsnwl kspdadsdql frmvaevfil
     3301 wckshnfkre eqnfviqnei nnlafltgds kskmsksggq dqerkktkrr gdlysiqtsl
     3361 ivaalkkmlp iglnmctpgd qelislaksr yshrdtdeev rehlrnnlhl qeksddpavk
     3421 wqlnlykdvl kseepfnpek tvervqrisa avfhleqveq plrskkavwh kllskqrkra
     3481 vvacfrmapl ynlprhkinn fflstfqqvw lekvnektqy drlipilmks pkveeeeeee
     3541 tekqpdplhq iilyfsrnal terskleddp lytsyssmma kscqsgedee ededkektfe
     3601 ekemekqktl yqqarlherg aaemvlqmis askgemspmv vetlklgiai lnggnagvqq
     3661 kmldylkekk dagffqslsg lmqscsvldl naferqnkae glgmvteegt livrergekv
     3721 lqndeftrdl frflqllceg hnsdfqnflr tqmgntttvn viistvdyll rlqesisdfy
     3781 wyysgkdiid esgqhnfska lavtkqifns lteyiqgpci gnqqslahsr lwdavvgflh
     3841 vfanmqmkls qdssqiellk elldllqdmv vmllsllegn vvngtigkqm vdtlvesstn
     3901 vemilkffdm flklkdltss dtfkeydpdg kgiiskkefq kamegqkqyt qseidfllsc
     3961 aeadendmfn yvdfvdrfhe pakdigfnva vlltnlsehm pndsrlkcll dpaesvlnyf
     4021 epylgrieim ggakkiervy feisessrtq wekpqvkesk rqfifdvvne ggeqekmelf
     4081 vnfcedtife mqlasqises dsadrpeeee ededssyvle iageeeedgs lepasafama
     4141 casvkrnvtd flkratlknl rkqyrnvkkm takelvkvlf sffwmlfvgl fqllftilgg
     4201 ifqilwstvf ggglvegakn irvtkilgdm pdptqfgihd dtmeaeraev mepgittelv
     4261 hfikgekgdt dimsdlfglh pkkegslkhg pevglgdlse iigkdepptl estvqkkrka
     4321 qaaemkaane aegkveseka dmedgekedk dkeeeqaeyl wtevtkkkkr rcgqkvekpe
     4381 aftanffkgl eiyqtkllhy larnfynlrf lalfvafain fillfykvte epleeetedv
     4441 anlwnsfnde eeeeamvffv lqestgymap tlralaiiht iislvcvvgy yclkvplvvf
     4501 krekeiarkl efdglyiteq pseddikgqw drlvintpsf pnnywdkfvk rkvinkygdl
     4561 ygaeriaell gldknaldfs pveetkaeaa slvswlssid mkyhiwklgv vftdnsflyl
     4621 awyttmsvlg hynnfffaah lldiamgfkt lrtilssvth ngkqlvltvg llavvvylyt
     4681 vvafnffrkf ynksedddep dmkcddmmtc ylfhmyvgvr agggigdeie dpagdpyemy
     4741 rivfditfff fvivillaii qgliidafge lrdqqeqvre dmetkcficg igndyfdttp
     4801 hgfethtlqe hnlanylffl mylinkdete htgqesyvwk myqercwdff pagdcfrkqy
     4861 edqlg
//
LOCUS       XP_016877960            4865 aa            linear   PRI 05-AUG-2025
DEFINITION  ryanodine receptor 3 isoform X4 [Homo sapiens].
ACCESSION   XP_016877960
VERSION     XP_016877960.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022471.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4865
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4865
                     /product="ryanodine receptor 3 isoform X4"
                     /calculated_mol_wt=551323
     Region          14..212
                     /region_name="Ins145_P3_rec"
                     /note="Inositol 1,4,5-trisphosphate/ryanodine receptor;
                     pfam08709"
                     /db_xref="CDD:462572"
     Region          216..405
                     /region_name="beta-trefoil_MIR_RyR3"
                     /note="MIR domain, beta-trefoil fold, found in ryanodine
                     receptor 3 (RyR3) and similar proteins; cd23292"
                     /db_xref="CDD:467763"
     Site            391
                     /site_type="other"
                     /note="putative homotetramer interface [polypeptide
                     binding]"
                     /db_xref="CDD:467763"
     Region          442..621
                     /region_name="RYDR_ITPR"
                     /note="RIH domain; pfam01365"
                     /db_xref="CDD:460175"
     Region          641..792
                     /region_name="SPRY1_RyR"
                     /note="SPRY domain 1 (SPRY1) of ryanodine receptor (RyR);
                     cd12877"
                     /db_xref="CDD:240457"
     Region          849..937
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          963..1052
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          1072..1204
                     /region_name="SPRY2_RyR"
                     /note="SPRY domain 2 (SPRY2) of ryanodine receptor (RyR);
                     cd12878"
                     /db_xref="CDD:240458"
     Region          1318..1461
                     /region_name="SPRY3_RyR"
                     /note="SPRY domain 3 (SPRY3) of ryanodine receptor (RyR);
                     cd12879"
                     /db_xref="CDD:293937"
     Region          2022..2232
                     /region_name="RYDR_ITPR"
                     /note="RIH domain; pfam01365"
                     /db_xref="CDD:460175"
     Region          2597..2686
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          2715..2794
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          3722..3839
                     /region_name="RIH_assoc"
                     /note="RyR and IP3R Homology associated; pfam08454"
                     /db_xref="CDD:462482"
     Region          3923..3978
                     /region_name="EF-hand_7"
                     /note="EF-hand domain pair; pfam13499"
                     /db_xref="CDD:463900"
     Region          4229..4499
                     /region_name="RR_TM4-6"
                     /note="Ryanodine Receptor TM 4-6; pfam06459"
                     /db_xref="CDD:461918"
     Region          <4616..4776
                     /region_name="Ion_trans"
                     /note="Ion transport protein; pfam00520"
                     /db_xref="CDD:459842"
     CDS             1..4865
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /coded_by="XM_017022471.2:80..14677"
                     /db_xref="GeneID:6263"
                     /db_xref="HGNC:HGNC:10485"
                     /db_xref="MIM:180903"
ORIGIN      
        1 maeggegged eiqflrtede vvlqciatih keqrkfclaa eglgnrlcfl eptseakyip
       61 pdlcvcnfvl eqslsvralq emlantgeng gegaaqgggh rtllyghavl lrhsfsgmyl
      121 tclttsrsqt dklafdvglr ehatgeacww tihpaskqrs egekvrigdd lilvsvsser
      181 ylhlsvsngn iqvdasfmqt lwnvhptcsg ssieegyllg ghvvrlfhgh decltipstd
      241 qndsqhrrif yeaggagtra rslwrveplr iswsgsnirw gqafrlrhlt tghylalted
      301 qglilqdrak sdtkstafsf raskelkekl dsshkrdieg mgvpeikygd svcfvqhias
      361 glwvtykaqd aktsrlgplk rkvilhqegh mddgltlqrc qreesqaari irnttalfsq
      421 fvsgnnrtaa pitlpieevl qtlqdliayf qppeeemrhe dkqnklrslk nrqnlfkeeg
      481 mlalvlncid rlnvynsvah fagiareesg mawkeilnll ykllaalirg nrnncaqfsn
      541 nldwliskld rlesssgile vlhciltesp ealnliaegh iksiislldk hgrnhkvldi
      601 lcslclcngv avranqnlic dnllprrnll lqtrlindvt sirpniflgv aegsaqykkw
      661 yfeliidqvd pfltaepthl rvgwasssgy apypgggegw ggngvgddly sygfdglhlw
      721 sgripravas inqhllrsdd vvsccldlgv psisfringq pvqgmfenfn tdglffpvms
      781 fsagvkvrfl mggrhgefkf lppsgyapcy eallpkekmr lepvkeykrd adgirdllgt
      841 tqflsqasfi pcpvdtsqvi lpphlekird rlaenihelw gmnkielgwt fgkirddnkr
      901 qhpclvefsk lpeteknynl qmstetlktl lalgchiahv npaaeedlkk vklpknymms
      961 ngykpapldl sdvkllppqe ilvdklaena hnvwakdrik qgwtygiqqd lknkrnprlv
     1021 pyalldertk ksnrdslrea vrtfvgygyn iepsdqelad savekvsidk irffrversy
     1081 avrsgkwyfe fevvtggdmr vgwarpgcrp dvelgaddqa fvfegnrgqr whqgsgyfgr
     1141 twqpgdvvgc minlddasmi ftlngellit nkgselafad yeiengfvpi cclglsqigr
     1201 mnlgtdastf kfytmcglqe gfepfavnmn rdvamwfskr lptfvnvpkd hphievmrid
     1261 gtmdsppclk vthktfgtqn snadmiycrl smpvechssf shspcldsea fqkrkqmqei
     1321 lshtttcyya irifagqdps cvwvgwvtpd yhlysekfdl nknctvtvtl gdergrvhes
     1381 vkrsncymvw ggdivassqr snrsnvdlei gclvdlamgm lsfsangkel gtcyqvepnt
     1441 kvfpavflqp tstslfqfel gklknampls aaifrseekn pvpqcpprld vqtiqpvlws
     1501 rmpnsflkve tervserhgw vvqcleplqm malhipeenr cvdilelceq edlmrfhyht
     1561 lrlysavcal gnsrvayalc shvdlsqlfy aidnkylpgl lrsgfydlli sihlasaker
     1621 klmmkneyii pitsttrnir lfpdeskrhg lpgvglrtcl kpgfrfstpc fvvtgedhqk
     1681 qspeiplesl rtkalsmlte avqcsgahir dpvggsvefq fvpvlkligt llvmgvfddd
     1741 dvrqilllid psvfgehsag teegaekeev tqveekavea gekagkeapv kgllqtrlpe
     1801 svklqmcell sylcdcelqh rveaivafgd iyvsklqanq kfrynelmqa lnmsaaltar
     1861 ktkefrsppq eqinmllnfq lgencpcpee ireelydfhe dlllhcgvpl eeeeeeeedt
     1921 swtgklcalv ykikgppkpe keqpteeeer cpttlkelis qtmicwaqed qiqdselvrm
     1981 mfnllrrqyd sigellqalr ktytishtsv sdtinllaal gqirsllsvr mgkeeellmi
     2041 nglgdimnnk vfyqhpnlmr vlgmhetvme vmvnvlgtek sqiafpkmva sccrflcyfc
     2101 risrqnqkam fehlsyllen ssvglaspsm rgstpldvaa ssvmdnnela lsleepdlek
     2161 vvtylagcgl qscpmllakg ypdvgwnpie gerylsflrf avfvnsesve enasvvvkll
     2221 irrpecfgpa lrgeggngll aamqgaikis enpaldlpsq gykrevstgd deeeeeivhm
     2281 gnaimsfysa lidllgrcap emhliqtgkg eairirsilr slvptedlvg iisiplklps
     2341 lnkdgsvsep dmaanfcpdh kapmvlfldr vygikdqtfl lhllevgflp dlrasasldt
     2401 vslstteaal alnryicsav lplltrcapl fagtehctsl idstlqtiyr lskgrsltka
     2461 qrdtieecll aicnhlrpsm lqqllrrlvf dvpqlneyck mplklltnhy eqcwkyyclp
     2521 sgwgsyglav eeelhltekl fwgifdslsh kkydpdlfrm alpclsaiag alppdyldtr
     2581 itatlekqis vdadgnfdpk pintmnfslp ekleyivtky aehshdkwac dksqsgwkyg
     2641 isldenvkth plirpfktlt ekekeiyrwp areslktmla vgwtvertke gealvqqren
     2701 eklrsvsqan qgnsyspapl dlsnvvlsre lqgmvevvae nyhniwakkk kleleskggg
     2761 shpllvpydt ltakekfkdr ekaqdlfkfl qvngiivsrg mkdmeldass mekrfaykfl
     2821 kkilkyvdsa qefiahleai vssgkteksp rdqeikffak vllplvdqyf tshclyflss
     2881 plkplsssgy ashkekemva glfcklaalv rhrislfgsd sttmvsclhi laqtldtrtv
     2941 mksgselvka glraffenaa edlektsenl klgkfthsrt qikgvsqnin yttvallpil
     3001 tsifehvtqh qfgmdlllgd vqiscyhilc slyslgtgkn iyverqrpal geclaslaaa
     3061 ipvafleptl nrynplsvfn tktprersil gmpdtvedmc pdipqleglm keindlaesg
     3121 arytemphvi evilpmlcny lsywwergpe nlppstgpcc tkvtsehlsl ilgnilkiin
     3181 nnlgideasw mkriavyaqp iiskarpdll rshfiptlek lkkkavktvq eeeqlkadgk
     3241 gdtqeaelli ldefavlcrd lyafypmlir yvdnnrsnwl kspdadsdql frmvaevfil
     3301 wckshnfkre eqnfviqnei nnlafltgds kskmsksggq dqerkktkrr gdlysiqtsl
     3361 ivaalkkmlp iglnmctpgd qelislaksr yshrdtdeev rehlrnnlhl qeksddpavk
     3421 wqlnlykdvl kseepfnpek tvervqrisa avfhleqveq plrskkavwh kllskqrkra
     3481 vvacfrmapl ynlprhkinn fflstfqqvw lekvnektqy drlipilmks pkveeeeeee
     3541 tekqpdplhq iilyfsrnal terskleddp lytsyssmma kscqsgedee ededkektfe
     3601 ekemekqktl yqqarlherg aaemvlqmis askgemspmv vetlklgiai lnggnagvqq
     3661 kmldylkekk dagffqslsg lmqscsvldl naferqnkae glgmvteegt livrergekv
     3721 lqndeftrdl frflqllceg hnsdfqnflr tqmgntttvn viistvdyll rlqesisdfy
     3781 wyysgkdiid esgqhnfska lavtkqifns lteyiqgpci gnqqslahsr lwdavvgflh
     3841 vfanmqmkls qdssqiellk elldllqdmv vmllsllegn vvngtigkqm vdtlvesstn
     3901 vemilkffdm flklkdltss dtfkeydpdg kgiiskkefq kamegqkqyt qseidfllsc
     3961 aeadendmfn yvdfvdrfhe pakdigfnva vlltnlsehm pndsrlkcll dpaesvlnyf
     4021 epylgrieim ggakkiervy feisessrtq wekpqvkesk rqfifdvvne ggeqekmelf
     4081 vnfcedtife mqlasqises dsadrpeeee ededssyvle iageeeedgs lepasafama
     4141 casvkrnvtd flkratlknl rkqyrnvkkm takelvkvlf sffwmlfvgl fqllftilgg
     4201 ifqilwstvf ggglvegakn irvtkilgdm pdptqfgihd dtmeaeraev mepgittelv
     4261 hfikgekgdt dimsdlfglh pkkegslkhg pevglgdlse iigkdepptl estvqkkrka
     4321 qaaemkaane aegkveseka dmedgekedk dkeeeqaeyl wtevtkkkkr rcgqkvekpe
     4381 aftanffkgl eiyqtkllhy larnfynlrf lalfvafain fillfykvte epleeetedv
     4441 anlwnsfnde eeeeamvffv lqestgymap tlralaiiht iislvcvvgy yclkvplvvf
     4501 krekeiarkl efdglyiteq pseddikgqw drlvintpsf pnnywdkfvk rkvinkygdl
     4561 ygaeriaell gldknaldfs pveetkaeaa slvswlssid mkyhiwklgv vftdnsflyl
     4621 awyttmsvlg hynnfffaah lldiamgfkt lrtilssvth ngkqlvltvg llavvvylyt
     4681 vvafnffrkf ynksedddep dmkcddmmtc ylfhmyvgvr agggigdeie dpagdpyemy
     4741 rivfditfff fvivillaii qgliidafge lrdqqeqvre dmetkcficg igndyfdttp
     4801 hgfethtlqe hnlanylffl mylinkdete htgqesyvwk myqercwdff pagdcfrkqy
     4861 edqlg
//
LOCUS       XP_016877961            4864 aa            linear   PRI 05-AUG-2025
DEFINITION  ryanodine receptor 3 isoform X5 [Homo sapiens].
ACCESSION   XP_016877961
VERSION     XP_016877961.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022472.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4864
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4864
                     /product="ryanodine receptor 3 isoform X5"
                     /calculated_mol_wt=551269
     Region          14..212
                     /region_name="Ins145_P3_rec"
                     /note="Inositol 1,4,5-trisphosphate/ryanodine receptor;
                     pfam08709"
                     /db_xref="CDD:462572"
     Region          216..405
                     /region_name="beta-trefoil_MIR_RyR3"
                     /note="MIR domain, beta-trefoil fold, found in ryanodine
                     receptor 3 (RyR3) and similar proteins; cd23292"
                     /db_xref="CDD:467763"
     Site            391
                     /site_type="other"
                     /note="putative homotetramer interface [polypeptide
                     binding]"
                     /db_xref="CDD:467763"
     Region          442..621
                     /region_name="RYDR_ITPR"
                     /note="RIH domain; pfam01365"
                     /db_xref="CDD:460175"
     Region          641..792
                     /region_name="SPRY1_RyR"
                     /note="SPRY domain 1 (SPRY1) of ryanodine receptor (RyR);
                     cd12877"
                     /db_xref="CDD:240457"
     Region          849..937
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          963..1052
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          1072..1204
                     /region_name="SPRY2_RyR"
                     /note="SPRY domain 2 (SPRY2) of ryanodine receptor (RyR);
                     cd12878"
                     /db_xref="CDD:240458"
     Region          1324..1462
                     /region_name="SPRY3_RyR"
                     /note="SPRY domain 3 (SPRY3) of ryanodine receptor (RyR);
                     cd12879"
                     /db_xref="CDD:293937"
     Region          2023..2233
                     /region_name="RYDR_ITPR"
                     /note="RIH domain; pfam01365"
                     /db_xref="CDD:460175"
     Region          2597..2686
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          2715..2794
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          3721..3838
                     /region_name="RIH_assoc"
                     /note="RyR and IP3R Homology associated; pfam08454"
                     /db_xref="CDD:462482"
     Region          3922..3977
                     /region_name="EF-hand_7"
                     /note="EF-hand domain pair; pfam13499"
                     /db_xref="CDD:463900"
     Region          4228..4498
                     /region_name="RR_TM4-6"
                     /note="Ryanodine Receptor TM 4-6; pfam06459"
                     /db_xref="CDD:461918"
     Region          <4615..4775
                     /region_name="Ion_trans"
                     /note="Ion transport protein; pfam00520"
                     /db_xref="CDD:459842"
     CDS             1..4864
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /coded_by="XM_017022472.2:80..14674"
                     /db_xref="GeneID:6263"
                     /db_xref="HGNC:HGNC:10485"
                     /db_xref="MIM:180903"
ORIGIN      
        1 maeggegged eiqflrtede vvlqciatih keqrkfclaa eglgnrlcfl eptseakyip
       61 pdlcvcnfvl eqslsvralq emlantgeng gegaaqgggh rtllyghavl lrhsfsgmyl
      121 tclttsrsqt dklafdvglr ehatgeacww tihpaskqrs egekvrigdd lilvsvsser
      181 ylhlsvsngn iqvdasfmqt lwnvhptcsg ssieegyllg ghvvrlfhgh decltipstd
      241 qndsqhrrif yeaggagtra rslwrveplr iswsgsnirw gqafrlrhlt tghylalted
      301 qglilqdrak sdtkstafsf raskelkekl dsshkrdieg mgvpeikygd svcfvqhias
      361 glwvtykaqd aktsrlgplk rkvilhqegh mddgltlqrc qreesqaari irnttalfsq
      421 fvsgnnrtaa pitlpieevl qtlqdliayf qppeeemrhe dkqnklrslk nrqnlfkeeg
      481 mlalvlncid rlnvynsvah fagiareesg mawkeilnll ykllaalirg nrnncaqfsn
      541 nldwliskld rlesssgile vlhciltesp ealnliaegh iksiislldk hgrnhkvldi
      601 lcslclcngv avranqnlic dnllprrnll lqtrlindvt sirpniflgv aegsaqykkw
      661 yfeliidqvd pfltaepthl rvgwasssgy apypgggegw ggngvgddly sygfdglhlw
      721 sgripravas inqhllrsdd vvsccldlgv psisfringq pvqgmfenfn tdglffpvms
      781 fsagvkvrfl mggrhgefkf lppsgyapcy eallpkekmr lepvkeykrd adgirdllgt
      841 tqflsqasfi pcpvdtsqvi lpphlekird rlaenihelw gmnkielgwt fgkirddnkr
      901 qhpclvefsk lpeteknynl qmstetlktl lalgchiahv npaaeedlkk vklpknymms
      961 ngykpapldl sdvkllppqe ilvdklaena hnvwakdrik qgwtygiqqd lknkrnprlv
     1021 pyalldertk ksnrdslrea vrtfvgygyn iepsdqelad savekvsidk irffrversy
     1081 avrsgkwyfe fevvtggdmr vgwarpgcrp dvelgaddqa fvfegnrgqr whqgsgyfgr
     1141 twqpgdvvgc minlddasmi ftlngellit nkgselafad yeiengfvpi cclglsqigr
     1201 mnlgtdastf kfytmcglqe gfepfavnmn rdvamwfskr lptfvnvpkd hphievmrid
     1261 gtmdsppclk vthktfgtqn snadmiycrl smpvechssf shspcldsea fqkrkqmqei
     1321 lshtttqcyy airifagqdp scvwvgwvtp dyhlysekfd lnknctvtvt lgdergrvhe
     1381 svkrsncymv wggdivassq rsnrsnvdle igclvdlamg mlsfsangke lgtcyqvepn
     1441 tkvfpavflq ptstslfqfe lgklknampl saaifrseek npvpqcpprl dvqtiqpvlw
     1501 srmpnsflkv etervserhg wvvqcleplq mmalhipeen rcvdilelce qedlmrfhyh
     1561 tlrlysavca lgnsrvayal cshvdlsqlf yaidnkylpg llrsgfydll isihlasake
     1621 rklmmkneyi ipitsttrni rlfpdeskrh glpgvglrtc lkpgfrfstp cfvvtgedhq
     1681 kqspeiples lrtkalsmlt eavqcsgahi rdpvggsvef qfvpvlklig tllvmgvfdd
     1741 ddvrqillli dpsvfgehsa gteegaekee vtqveekave agekagkeap vkgllqtrlp
     1801 esvklqmcel lsylcdcelq hrveaivafg diyvsklqan qkfrynelmq alnmsaalta
     1861 rktkefrspp qeqinmllnf qlgencpcpe eireelydfh edlllhcgvp leeeeeeeed
     1921 tswtgklcal vykikgppkp ekeqpteeee rcpttlkeli sqtmicwaqe dqiqdselvr
     1981 mmfnllrrqy dsigellqal rktytishts vsdtinllaa lgqirsllsv rmgkeeellm
     2041 inglgdimnn kvfyqhpnlm rvlgmhetvm evmvnvlgte ksqiafpkmv asccrflcyf
     2101 crisrqnqka mfehlsylle nssvglasps mrgstpldva assvmdnnel alsleepdle
     2161 kvvtylagcg lqscpmllak gypdvgwnpi egerylsflr favfvnsesv eenasvvvkl
     2221 lirrpecfgp alrgeggngl laamqgaiki senpaldlps qgykrevtgd deeeeeivhm
     2281 gnaimsfysa lidllgrcap emhliqtgkg eairirsilr slvptedlvg iisiplklps
     2341 lnkdgsvsep dmaanfcpdh kapmvlfldr vygikdqtfl lhllevgflp dlrasasldt
     2401 vslstteaal alnryicsav lplltrcapl fagtehctsl idstlqtiyr lskgrsltka
     2461 qrdtieecll aicnhlrpsm lqqllrrlvf dvpqlneyck mplklltnhy eqcwkyyclp
     2521 sgwgsyglav eeelhltekl fwgifdslsh kkydpdlfrm alpclsaiag alppdyldtr
     2581 itatlekqis vdadgnfdpk pintmnfslp ekleyivtky aehshdkwac dksqsgwkyg
     2641 isldenvkth plirpfktlt ekekeiyrwp areslktmla vgwtvertke gealvqqren
     2701 eklrsvsqan qgnsyspapl dlsnvvlsre lqgmvevvae nyhniwakkk kleleskggg
     2761 shpllvpydt ltakekfkdr ekaqdlfkfl qvngiivsrg mkdmeldass mekrfaykfl
     2821 kkilkyvdsa qefiahleai vssgkteksp rdqeikffak vllplvdqyf tshclyflss
     2881 plkplsssgy ashkekemva glfcklaalv rhrislfgsd sttmvsclhi laqtldtrtv
     2941 mksgselvka glraffenaa edlektsenl klgkfthsrt qikgvsqnin yttvallpil
     3001 tsifehvtqh qfgmdlllgd vqiscyhilc slyslgtgkn iyverqrpal geclaslaaa
     3061 ipvafleptl nrynplsvfn tktprersil gmpdtvedmc pdipqleglm keindlaesg
     3121 arytemphvi evilpmlcny lsywwergpe nlppstgpcc tkvtsehlsl ilgnilkiin
     3181 nnlgideasw mkriavyaqp iiskarpdll rshfiptlek lkkkavktvq eeeqlkadgk
     3241 gdtqeaelli ldefavlcrd lyafypmlir yvdnnrsnwl kspdadsdql frmvaevfil
     3301 wckshnfkre eqnfviqnei nnlafltgds kskmsksggq dqerkktkrr gdlysiqtsl
     3361 ivaalkkmlp iglnmctpgd qelislaksr yshrdtdeev rehlrnnlhl qeksddpavk
     3421 wqlnlykdvl kseepfnpek tvervqrisa avfhleqveq plrskkavwh kllskqrkra
     3481 vvacfrmapl ynlprhrsin lflhgyqrfw ieteeysfee klvqdlaksp kveeeeeeet
     3541 ekqpdplhqi ilyfsrnalt erskleddpl ytsyssmmak scqsgedeee dedkektfee
     3601 kemekqktly qqarlherga aemvlqmisa skgemspmvv etlklgiail nggnagvqqk
     3661 mldylkekkd agffqslsgl mqscsvldln aferqnkaeg lgmvteegtl ivrergekvl
     3721 qndeftrdlf rflqllcegh nsdfqnflrt qmgntttvnv iistvdyllr lqesisdfyw
     3781 yysgkdiide sgqhnfskal avtkqifnsl teyiqgpcig nqqslahsrl wdavvgflhv
     3841 fanmqmklsq dssqiellke lldllqdmvv mllsllegnv vngtigkqmv dtlvesstnv
     3901 emilkffdmf lklkdltssd tfkeydpdgk giiskkefqk amegqkqytq seidfllsca
     3961 eadendmfny vdfvdrfhep akdigfnvav lltnlsehmp ndsrlkclld paesvlnyfe
     4021 pylgrieimg gakkiervyf eisessrtqw ekpqvkeskr qfifdvvneg geqekmelfv
     4081 nfcedtifem qlasqisesd sadrpeeeee dedssyvlei ageeeedgsl epasafamac
     4141 asvkrnvtdf lkratlknlr kqyrnvkkmt akelvkvlfs ffwmlfvglf qllftilggi
     4201 fqilwstvfg gglvegakni rvtkilgdmp dptqfgihdd tmeaeraevm epgittelvh
     4261 fikgekgdtd imsdlfglhp kkegslkhgp evglgdlsei igkdepptle stvqkkrkaq
     4321 aaemkaanea egkvesekad medgekedkd keeeqaeylw tevtkkkkrr cgqkvekpea
     4381 ftanffkgle iyqtkllhyl arnfynlrfl alfvafainf illfykvtee pleeetedva
     4441 nlwnsfndee eeeamvffvl qestgymapt lralaiihti islvcvvgyy clkvplvvfk
     4501 rekeiarkle fdglyiteqp seddikgqwd rlvintpsfp nnywdkfvkr kvinkygdly
     4561 gaeriaellg ldknaldfsp veetkaeaas lvswlssidm kyhiwklgvv ftdnsflyla
     4621 wyttmsvlgh ynnfffaahl ldiamgfktl rtilssvthn gkqlvltvgl lavvvylytv
     4681 vafnffrkfy nksedddepd mkcddmmtcy lfhmyvgvra gggigdeied pagdpyemyr
     4741 ivfditffff vivillaiiq gliidafgel rdqqeqvred metkcficgi gndyfdttph
     4801 gfethtlqeh nlanylfflm ylinkdeteh tgqesyvwkm yqercwdffp agdcfrkqye
     4861 dqlg
//
LOCUS       XP_024305783            4864 aa            linear   PRI 05-AUG-2025
DEFINITION  ryanodine receptor 3 isoform X6 [Homo sapiens].
ACCESSION   XP_024305783
VERSION     XP_024305783.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024450015.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4864
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4864
                     /product="ryanodine receptor 3 isoform X6"
                     /calculated_mol_wt=551236
     Region          14..212
                     /region_name="Ins145_P3_rec"
                     /note="Inositol 1,4,5-trisphosphate/ryanodine receptor;
                     pfam08709"
                     /db_xref="CDD:462572"
     Region          216..405
                     /region_name="beta-trefoil_MIR_RyR3"
                     /note="MIR domain, beta-trefoil fold, found in ryanodine
                     receptor 3 (RyR3) and similar proteins; cd23292"
                     /db_xref="CDD:467763"
     Site            391
                     /site_type="other"
                     /note="putative homotetramer interface [polypeptide
                     binding]"
                     /db_xref="CDD:467763"
     Region          442..621
                     /region_name="RYDR_ITPR"
                     /note="RIH domain; pfam01365"
                     /db_xref="CDD:460175"
     Region          641..792
                     /region_name="SPRY1_RyR"
                     /note="SPRY domain 1 (SPRY1) of ryanodine receptor (RyR);
                     cd12877"
                     /db_xref="CDD:240457"
     Region          849..937
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          963..1052
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          1072..1204
                     /region_name="SPRY2_RyR"
                     /note="SPRY domain 2 (SPRY2) of ryanodine receptor (RyR);
                     cd12878"
                     /db_xref="CDD:240458"
     Region          1318..1461
                     /region_name="SPRY3_RyR"
                     /note="SPRY domain 3 (SPRY3) of ryanodine receptor (RyR);
                     cd12879"
                     /db_xref="CDD:293937"
     Region          2022..2232
                     /region_name="RYDR_ITPR"
                     /note="RIH domain; pfam01365"
                     /db_xref="CDD:460175"
     Region          2596..2685
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          2714..2793
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          3721..3838
                     /region_name="RIH_assoc"
                     /note="RyR and IP3R Homology associated; pfam08454"
                     /db_xref="CDD:462482"
     Region          3922..3977
                     /region_name="EF-hand_7"
                     /note="EF-hand domain pair; pfam13499"
                     /db_xref="CDD:463900"
     Region          4228..4498
                     /region_name="RR_TM4-6"
                     /note="Ryanodine Receptor TM 4-6; pfam06459"
                     /db_xref="CDD:461918"
     Region          <4615..4775
                     /region_name="Ion_trans"
                     /note="Ion transport protein; pfam00520"
                     /db_xref="CDD:459842"
     CDS             1..4864
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /coded_by="XM_024450015.2:80..14674"
                     /db_xref="GeneID:6263"
                     /db_xref="HGNC:HGNC:10485"
                     /db_xref="MIM:180903"
ORIGIN      
        1 maeggegged eiqflrtede vvlqciatih keqrkfclaa eglgnrlcfl eptseakyip
       61 pdlcvcnfvl eqslsvralq emlantgeng gegaaqgggh rtllyghavl lrhsfsgmyl
      121 tclttsrsqt dklafdvglr ehatgeacww tihpaskqrs egekvrigdd lilvsvsser
      181 ylhlsvsngn iqvdasfmqt lwnvhptcsg ssieegyllg ghvvrlfhgh decltipstd
      241 qndsqhrrif yeaggagtra rslwrveplr iswsgsnirw gqafrlrhlt tghylalted
      301 qglilqdrak sdtkstafsf raskelkekl dsshkrdieg mgvpeikygd svcfvqhias
      361 glwvtykaqd aktsrlgplk rkvilhqegh mddgltlqrc qreesqaari irnttalfsq
      421 fvsgnnrtaa pitlpieevl qtlqdliayf qppeeemrhe dkqnklrslk nrqnlfkeeg
      481 mlalvlncid rlnvynsvah fagiareesg mawkeilnll ykllaalirg nrnncaqfsn
      541 nldwliskld rlesssgile vlhciltesp ealnliaegh iksiislldk hgrnhkvldi
      601 lcslclcngv avranqnlic dnllprrnll lqtrlindvt sirpniflgv aegsaqykkw
      661 yfeliidqvd pfltaepthl rvgwasssgy apypgggegw ggngvgddly sygfdglhlw
      721 sgripravas inqhllrsdd vvsccldlgv psisfringq pvqgmfenfn tdglffpvms
      781 fsagvkvrfl mggrhgefkf lppsgyapcy eallpkekmr lepvkeykrd adgirdllgt
      841 tqflsqasfi pcpvdtsqvi lpphlekird rlaenihelw gmnkielgwt fgkirddnkr
      901 qhpclvefsk lpeteknynl qmstetlktl lalgchiahv npaaeedlkk vklpknymms
      961 ngykpapldl sdvkllppqe ilvdklaena hnvwakdrik qgwtygiqqd lknkrnprlv
     1021 pyalldertk ksnrdslrea vrtfvgygyn iepsdqelad savekvsidk irffrversy
     1081 avrsgkwyfe fevvtggdmr vgwarpgcrp dvelgaddqa fvfegnrgqr whqgsgyfgr
     1141 twqpgdvvgc minlddasmi ftlngellit nkgselafad yeiengfvpi cclglsqigr
     1201 mnlgtdastf kfytmcglqe gfepfavnmn rdvamwfskr lptfvnvpkd hphievmrid
     1261 gtmdsppclk vthktfgtqn snadmiycrl smpvechssf shspcldsea fqkrkqmqei
     1321 lshtttcyya irifagqdps cvwvgwvtpd yhlysekfdl nknctvtvtl gdergrvhes
     1381 vkrsncymvw ggdivassqr snrsnvdlei gclvdlamgm lsfsangkel gtcyqvepnt
     1441 kvfpavflqp tstslfqfel gklknampls aaifrseekn pvpqcpprld vqtiqpvlws
     1501 rmpnsflkve tervserhgw vvqcleplqm malhipeenr cvdilelceq edlmrfhyht
     1561 lrlysavcal gnsrvayalc shvdlsqlfy aidnkylpgl lrsgfydlli sihlasaker
     1621 klmmkneyii pitsttrnir lfpdeskrhg lpgvglrtcl kpgfrfstpc fvvtgedhqk
     1681 qspeiplesl rtkalsmlte avqcsgahir dpvggsvefq fvpvlkligt llvmgvfddd
     1741 dvrqilllid psvfgehsag teegaekeev tqveekavea gekagkeapv kgllqtrlpe
     1801 svklqmcell sylcdcelqh rveaivafgd iyvsklqanq kfrynelmqa lnmsaaltar
     1861 ktkefrsppq eqinmllnfq lgencpcpee ireelydfhe dlllhcgvpl eeeeeeeedt
     1921 swtgklcalv ykikgppkpe keqpteeeer cpttlkelis qtmicwaqed qiqdselvrm
     1981 mfnllrrqyd sigellqalr ktytishtsv sdtinllaal gqirsllsvr mgkeeellmi
     2041 nglgdimnnk vfyqhpnlmr vlgmhetvme vmvnvlgtek sqiafpkmva sccrflcyfc
     2101 risrqnqkam fehlsyllen ssvglaspsm rgstpldvaa ssvmdnnela lsleepdlek
     2161 vvtylagcgl qscpmllakg ypdvgwnpie gerylsflrf avfvnsesve enasvvvkll
     2221 irrpecfgpa lrgeggngll aamqgaikis enpaldlpsq gykrevtgdd eeeeeivhmg
     2281 naimsfysal idllgrcape mhliqtgkge airirsilrs lvptedlvgi isiplklpsl
     2341 nkdgsvsepd maanfcpdhk apmvlfldrv ygikdqtfll hllevgflpd lrasasldtv
     2401 slstteaala lnryicsavl plltrcaplf agtehctsli dstlqtiyrl skgrsltkaq
     2461 rdtieeclla icnhlrpsml qqllrrlvfd vpqlneyckm plklltnhye qcwkyyclps
     2521 gwgsyglave eelhlteklf wgifdslshk kydpdlfrma lpclsaiaga lppdyldtri
     2581 tatlekqisv dadgnfdpkp intmnfslpe kleyivtkya ehshdkwacd ksqsgwkygi
     2641 sldenvkthp lirpfktlte kekeiyrwpa reslktmlav gwtvertkeg ealvqqrene
     2701 klrsvsqanq gnsyspapld lsnvvlsrel qgmvevvaen yhniwakkkk leleskgggs
     2761 hpllvpydtl takekfkdre kaqdlfkflq vngiivsrgm kdmeldassm ekrfaykflk
     2821 kilkyvdsaq efiahleaiv ssgktekspr dqeikffakv llplvdqyft shclyflssp
     2881 lkplsssgya shkekemvag lfcklaalvr hrislfgsds ttmvsclhil aqtldtrtvm
     2941 ksgselvkag lraffenaae dlektsenlk lgkfthsrtq ikgvsqniny ttvallpilt
     3001 sifehvtqhq fgmdlllgdv qiscyhilcs lyslgtgkni yverqrpalg eclaslaaai
     3061 pvafleptln rynplsvfnt ktprersilg mpdtvedmcp dipqleglmk eindlaesga
     3121 rytemphvie vilpmlcnyl sywwergpen lppstgpcct kvtsehlsli lgnilkiinn
     3181 nlgideaswm kriavyaqpi iskarpdllr shfiptlekl kkkavktvqe eeqlkadgkg
     3241 dtqeaellil defavlcrdl yafypmliry vdnnrsnwlk spdadsdqlf rmvaevfilw
     3301 ckshnfkree qnfviqnein nlafltgdsk skmsksggqd qerkktkrrg dlysiqtsli
     3361 vaalkkmlpi glnmctpgdq elislaksry shrdtdeevr ehlrnnlhlq eksddpavkw
     3421 qlnlykdvlk seepfnpekt vervqrisaa vfhleqveqp lrskkavwhk llskqrkrav
     3481 vacfrmaply nlprhkinnf flstfqqvwl ekvnektqyd rlipilmksp kveeeeeeet
     3541 ekqpdplhqi ilyfsrnalt erskleddpl ytsyssmmak scqsgedeee dedkektfee
     3601 kemekqktly qqarlherga aemvlqmisa skgemspmvv etlklgiail nggnagvqqk
     3661 mldylkekkd agffqslsgl mqscsvldln aferqnkaeg lgmvteegtl ivrergekvl
     3721 qndeftrdlf rflqllcegh nsdfqnflrt qmgntttvnv iistvdyllr lqesisdfyw
     3781 yysgkdiide sgqhnfskal avtkqifnsl teyiqgpcig nqqslahsrl wdavvgflhv
     3841 fanmqmklsq dssqiellke lldllqdmvv mllsllegnv vngtigkqmv dtlvesstnv
     3901 emilkffdmf lklkdltssd tfkeydpdgk giiskkefqk amegqkqytq seidfllsca
     3961 eadendmfny vdfvdrfhep akdigfnvav lltnlsehmp ndsrlkclld paesvlnyfe
     4021 pylgrieimg gakkiervyf eisessrtqw ekpqvkeskr qfifdvvneg geqekmelfv
     4081 nfcedtifem qlasqisesd sadrpeeeee dedssyvlei ageeeedgsl epasafamac
     4141 asvkrnvtdf lkratlknlr kqyrnvkkmt akelvkvlfs ffwmlfvglf qllftilggi
     4201 fqilwstvfg gglvegakni rvtkilgdmp dptqfgihdd tmeaeraevm epgittelvh
     4261 fikgekgdtd imsdlfglhp kkegslkhgp evglgdlsei igkdepptle stvqkkrkaq
     4321 aaemkaanea egkvesekad medgekedkd keeeqaeylw tevtkkkkrr cgqkvekpea
     4381 ftanffkgle iyqtkllhyl arnfynlrfl alfvafainf illfykvtee pleeetedva
     4441 nlwnsfndee eeeamvffvl qestgymapt lralaiihti islvcvvgyy clkvplvvfk
     4501 rekeiarkle fdglyiteqp seddikgqwd rlvintpsfp nnywdkfvkr kvinkygdly
     4561 gaeriaellg ldknaldfsp veetkaeaas lvswlssidm kyhiwklgvv ftdnsflyla
     4621 wyttmsvlgh ynnfffaahl ldiamgfktl rtilssvthn gkqlvltvgl lavvvylytv
     4681 vafnffrkfy nksedddepd mkcddmmtcy lfhmyvgvra gggigdeied pagdpyemyr
     4741 ivfditffff vivillaiiq gliidafgel rdqqeqvred metkcficgi gndyfdttph
     4801 gfethtlqeh nlanylfflm ylinkdeteh tgqesyvwkm yqercwdffp agdcfrkqye
     4861 dqlg
//
LOCUS       XP_016877962            4860 aa            linear   PRI 05-AUG-2025
DEFINITION  ryanodine receptor 3 isoform X7 [Homo sapiens].
ACCESSION   XP_016877962
VERSION     XP_016877962.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022473.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4860
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4860
                     /product="ryanodine receptor 3 isoform X7"
                     /calculated_mol_wt=550784
     Region          14..212
                     /region_name="Ins145_P3_rec"
                     /note="Inositol 1,4,5-trisphosphate/ryanodine receptor;
                     pfam08709"
                     /db_xref="CDD:462572"
     Region          216..405
                     /region_name="beta-trefoil_MIR_RyR3"
                     /note="MIR domain, beta-trefoil fold, found in ryanodine
                     receptor 3 (RyR3) and similar proteins; cd23292"
                     /db_xref="CDD:467763"
     Site            391
                     /site_type="other"
                     /note="putative homotetramer interface [polypeptide
                     binding]"
                     /db_xref="CDD:467763"
     Region          442..621
                     /region_name="RYDR_ITPR"
                     /note="RIH domain; pfam01365"
                     /db_xref="CDD:460175"
     Region          641..792
                     /region_name="SPRY1_RyR"
                     /note="SPRY domain 1 (SPRY1) of ryanodine receptor (RyR);
                     cd12877"
                     /db_xref="CDD:240457"
     Region          849..937
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          963..1052
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          1072..1204
                     /region_name="SPRY2_RyR"
                     /note="SPRY domain 2 (SPRY2) of ryanodine receptor (RyR);
                     cd12878"
                     /db_xref="CDD:240458"
     Region          1324..1462
                     /region_name="SPRY3_RyR"
                     /note="SPRY domain 3 (SPRY3) of ryanodine receptor (RyR);
                     cd12879"
                     /db_xref="CDD:293937"
     Region          2023..2233
                     /region_name="RYDR_ITPR"
                     /note="RIH domain; pfam01365"
                     /db_xref="CDD:460175"
     Region          2598..2687
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          2716..2795
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          3717..3834
                     /region_name="RIH_assoc"
                     /note="RyR and IP3R Homology associated; pfam08454"
                     /db_xref="CDD:462482"
     Region          3918..3973
                     /region_name="EF-hand_7"
                     /note="EF-hand domain pair; pfam13499"
                     /db_xref="CDD:463900"
     Region          4224..4494
                     /region_name="RR_TM4-6"
                     /note="Ryanodine Receptor TM 4-6; pfam06459"
                     /db_xref="CDD:461918"
     Region          <4611..4771
                     /region_name="Ion_trans"
                     /note="Ion transport protein; pfam00520"
                     /db_xref="CDD:459842"
     CDS             1..4860
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /coded_by="XM_017022473.2:80..14662"
                     /db_xref="GeneID:6263"
                     /db_xref="HGNC:HGNC:10485"
                     /db_xref="MIM:180903"
ORIGIN      
        1 maeggegged eiqflrtede vvlqciatih keqrkfclaa eglgnrlcfl eptseakyip
       61 pdlcvcnfvl eqslsvralq emlantgeng gegaaqgggh rtllyghavl lrhsfsgmyl
      121 tclttsrsqt dklafdvglr ehatgeacww tihpaskqrs egekvrigdd lilvsvsser
      181 ylhlsvsngn iqvdasfmqt lwnvhptcsg ssieegyllg ghvvrlfhgh decltipstd
      241 qndsqhrrif yeaggagtra rslwrveplr iswsgsnirw gqafrlrhlt tghylalted
      301 qglilqdrak sdtkstafsf raskelkekl dsshkrdieg mgvpeikygd svcfvqhias
      361 glwvtykaqd aktsrlgplk rkvilhqegh mddgltlqrc qreesqaari irnttalfsq
      421 fvsgnnrtaa pitlpieevl qtlqdliayf qppeeemrhe dkqnklrslk nrqnlfkeeg
      481 mlalvlncid rlnvynsvah fagiareesg mawkeilnll ykllaalirg nrnncaqfsn
      541 nldwliskld rlesssgile vlhciltesp ealnliaegh iksiislldk hgrnhkvldi
      601 lcslclcngv avranqnlic dnllprrnll lqtrlindvt sirpniflgv aegsaqykkw
      661 yfeliidqvd pfltaepthl rvgwasssgy apypgggegw ggngvgddly sygfdglhlw
      721 sgripravas inqhllrsdd vvsccldlgv psisfringq pvqgmfenfn tdglffpvms
      781 fsagvkvrfl mggrhgefkf lppsgyapcy eallpkekmr lepvkeykrd adgirdllgt
      841 tqflsqasfi pcpvdtsqvi lpphlekird rlaenihelw gmnkielgwt fgkirddnkr
      901 qhpclvefsk lpeteknynl qmstetlktl lalgchiahv npaaeedlkk vklpknymms
      961 ngykpapldl sdvkllppqe ilvdklaena hnvwakdrik qgwtygiqqd lknkrnprlv
     1021 pyalldertk ksnrdslrea vrtfvgygyn iepsdqelad savekvsidk irffrversy
     1081 avrsgkwyfe fevvtggdmr vgwarpgcrp dvelgaddqa fvfegnrgqr whqgsgyfgr
     1141 twqpgdvvgc minlddasmi ftlngellit nkgselafad yeiengfvpi cclglsqigr
     1201 mnlgtdastf kfytmcglqe gfepfavnmn rdvamwfskr lptfvnvpkd hphievmrid
     1261 gtmdsppclk vthktfgtqn snadmiycrl smpvechssf shspcldsea fqkrkqmqei
     1321 lshtttqcyy airifagqdp scvwvgwvtp dyhlysekfd lnknctvtvt lgdergrvhe
     1381 svkrsncymv wggdivassq rsnrsnvdle igclvdlamg mlsfsangke lgtcyqvepn
     1441 tkvfpavflq ptstslfqfe lgklknampl saaifrseek npvpqcpprl dvqtiqpvlw
     1501 srmpnsflkv etervserhg wvvqcleplq mmalhipeen rcvdilelce qedlmrfhyh
     1561 tlrlysavca lgnsrvayal cshvdlsqlf yaidnkylpg llrsgfydll isihlasake
     1621 rklmmkneyi ipitsttrni rlfpdeskrh glpgvglrtc lkpgfrfstp cfvvtgedhq
     1681 kqspeiples lrtkalsmlt eavqcsgahi rdpvggsvef qfvpvlklig tllvmgvfdd
     1741 ddvrqillli dpsvfgehsa gteegaekee vtqveekave agekagkeap vkgllqtrlp
     1801 esvklqmcel lsylcdcelq hrveaivafg diyvsklqan qkfrynelmq alnmsaalta
     1861 rktkefrspp qeqinmllnf qlgencpcpe eireelydfh edlllhcgvp leeeeeeeed
     1921 tswtgklcal vykikgppkp ekeqpteeee rcpttlkeli sqtmicwaqe dqiqdselvr
     1981 mmfnllrrqy dsigellqal rktytishts vsdtinllaa lgqirsllsv rmgkeeellm
     2041 inglgdimnn kvfyqhpnlm rvlgmhetvm evmvnvlgte ksqiafpkmv asccrflcyf
     2101 crisrqnqka mfehlsylle nssvglasps mrgstpldva assvmdnnel alsleepdle
     2161 kvvtylagcg lqscpmllak gypdvgwnpi egerylsflr favfvnsesv eenasvvvkl
     2221 lirrpecfgp alrgeggngl laamqgaiki senpaldlps qgykrevstg ddeeeeeivh
     2281 mgnaimsfys alidllgrca pemhliqtgk geairirsil rslvptedlv giisiplklp
     2341 slnkdgsvse pdmaanfcpd hkapmvlfld rvygikdqtf llhllevgfl pdlrasasld
     2401 tvslstteaa lalnryicsa vlplltrcap lfagtehcts lidstlqtiy rlskgrsltk
     2461 aqrdtieecl laicnhlrps mlqqllrrlv fdvpqlneyc kmplklltnh yeqcwkyycl
     2521 psgwgsygla veeelhltek lfwgifdsls hkkydpdlfr malpclsaia galppdyldt
     2581 ritatlekqi svdadgnfdp kpintmnfsl pekleyivtk yaehshdkwa cdksqsgwky
     2641 gisldenvkt hplirpfktl tekekeiyrw pareslktml avgwtvertk egealvqqre
     2701 neklrsvsqa nqgnsyspap ldlsnvvlsr elqgmvevva enyhniwakk kkleleskgg
     2761 gshpllvpyd tltakekfkd rekaqdlfkf lqvngiivsr gmkdmeldas smekrfaykf
     2821 lkkilkyvds aqefiahlea ivssgkteks prdqeikffa kvllplvdqy ftshclyfls
     2881 splkplsssg yashkekemv aglfcklaal vrhrislfgs dsttmvsclh ilaqtldtrt
     2941 vmksgselvk aglraffena aedlektsen lklgkfthsr tqikgvsqni nyttvallpi
     3001 ltsifehvtq hqfgmdlllg dvqiscyhil cslyslgtgk niyverqrpa lgeclaslaa
     3061 aipvaflept lnrynplsvf ntktprersi lgmpdtvedm cpdipqlegl mkeindlaes
     3121 garytemphv ievilpmlcn ylsywwergp enlppstgpc ctkvtsehls lilgnilkii
     3181 nnnlgideas wmkriavyaq piiskarpdl lrshfiptle klkkkavktv qeeeqlkadg
     3241 kgdtqeaell ildefavlcr dlyafypmli ryvdnnrsnw lkspdadsdq lfrmvaevfi
     3301 lwckshnfkr eeqnfviqne innlafltgd skskmsksgg qdqerkktkr rgdlysiqts
     3361 livaalkkml piglnmctpg dqelislaks ryshrdtdee vrehlrnnlh lqeksddpav
     3421 kwqlnlykdv lkseepfnpe ktvervqris aavfhleqve qplrskkavw hkllskqrkr
     3481 avvacfrmap lynlprhkin nfflstfqqv wlekvnektq ydrlipilmk spkveeeeee
     3541 etekqpdplh qiilyfsrna lterskledd plytsyssmm akscqsgede eededkektf
     3601 eekemekqkt lyqqarlher gaaemvlqmi saskgemspm vvetlklgia ilnggnagvq
     3661 qkmldylkek kdagffqsls glmqscsvld lnaferqnka eglgmvteeg trekvlqnde
     3721 ftrdlfrflq llceghnsdf qnflrtqmgn tttvnviist vdyllrlqes isdfywyysg
     3781 kdiidesgqh nfskalavtk qifnslteyi qgpcignqqs lahsrlwdav vgflhvfanm
     3841 qmklsqdssq iellkelldl lqdmvvmlls llegnvvngt igkqmvdtlv esstnvemil
     3901 kffdmflklk dltssdtfke ydpdgkgiis kkefqkameg qkqytqseid fllscaeade
     3961 ndmfnyvdfv drfhepakdi gfnvavlltn lsehmpndsr lkclldpaes vlnyfepylg
     4021 rieimggakk iervyfeise ssrtqwekpq vkeskrqfif dvvneggeqe kmelfvnfce
     4081 dtifemqlas qisesdsadr peeeeededs syvleiagee eedgslepas afamacasvk
     4141 rnvtdflkra tlknlrkqyr nvkkmtakel vkvlfsffwm lfvglfqllf tilggifqil
     4201 wstvfggglv egaknirvtk ilgdmpdptq fgihddtmea eraevmepgi ttelvhfikg
     4261 ekgdtdimsd lfglhpkkeg slkhgpevgl gdlseiigkd epptlestvq kkrkaqaaem
     4321 kaaneaegkv esekadmedg ekedkdkeee qaeylwtevt kkkkrrcgqk vekpeaftan
     4381 ffkgleiyqt kllhylarnf ynlrflalfv afainfillf ykvteeplee etedvanlwn
     4441 sfndeeeeea mvffvlqest gymaptlral aiihtiislv cvvgyyclkv plvvfkreke
     4501 iarklefdgl yiteqpsedd ikgqwdrlvi ntpsfpnnyw dkfvkrkvin kygdlygaer
     4561 iaellgldkn aldfspveet kaeaaslvsw lssidmkyhi wklgvvftdn sflylawytt
     4621 msvlghynnf ffaahlldia mgfktlrtil ssvthngkql vltvgllavv vylytvvafn
     4681 ffrkfynkse dddepdmkcd dmmtcylfhm yvgvragggi gdeiedpagd pyemyrivfd
     4741 itffffvivi llaiiqglii dafgelrdqq eqvredmetk cficgigndy fdttphgfet
     4801 htlqehnlan ylfflmylin kdetehtgqe syvwkmyqer cwdffpagdc frkqyedqlg
//
LOCUS       XP_011520182            4859 aa            linear   PRI 05-AUG-2025
DEFINITION  ryanodine receptor 3 isoform X8 [Homo sapiens].
ACCESSION   XP_011520182
VERSION     XP_011520182.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521880.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4859
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4859
                     /product="ryanodine receptor 3 isoform X8"
                     /calculated_mol_wt=550697
     Region          14..212
                     /region_name="Ins145_P3_rec"
                     /note="Inositol 1,4,5-trisphosphate/ryanodine receptor;
                     pfam08709"
                     /db_xref="CDD:462572"
     Region          216..405
                     /region_name="beta-trefoil_MIR_RyR3"
                     /note="MIR domain, beta-trefoil fold, found in ryanodine
                     receptor 3 (RyR3) and similar proteins; cd23292"
                     /db_xref="CDD:467763"
     Site            391
                     /site_type="other"
                     /note="putative homotetramer interface [polypeptide
                     binding]"
                     /db_xref="CDD:467763"
     Region          442..621
                     /region_name="RYDR_ITPR"
                     /note="RIH domain; pfam01365"
                     /db_xref="CDD:460175"
     Region          641..792
                     /region_name="SPRY1_RyR"
                     /note="SPRY domain 1 (SPRY1) of ryanodine receptor (RyR);
                     cd12877"
                     /db_xref="CDD:240457"
     Region          849..937
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          963..1052
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          1072..1204
                     /region_name="SPRY2_RyR"
                     /note="SPRY domain 2 (SPRY2) of ryanodine receptor (RyR);
                     cd12878"
                     /db_xref="CDD:240458"
     Region          1324..1462
                     /region_name="SPRY3_RyR"
                     /note="SPRY domain 3 (SPRY3) of ryanodine receptor (RyR);
                     cd12879"
                     /db_xref="CDD:293937"
     Region          2023..2233
                     /region_name="RYDR_ITPR"
                     /note="RIH domain; pfam01365"
                     /db_xref="CDD:460175"
     Region          2597..2686
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          2715..2794
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          3716..3833
                     /region_name="RIH_assoc"
                     /note="RyR and IP3R Homology associated; pfam08454"
                     /db_xref="CDD:462482"
     Region          3917..3972
                     /region_name="EF-hand_7"
                     /note="EF-hand domain pair; pfam13499"
                     /db_xref="CDD:463900"
     Region          4223..4493
                     /region_name="RR_TM4-6"
                     /note="Ryanodine Receptor TM 4-6; pfam06459"
                     /db_xref="CDD:461918"
     Region          <4610..4770
                     /region_name="Ion_trans"
                     /note="Ion transport protein; pfam00520"
                     /db_xref="CDD:459842"
     CDS             1..4859
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /coded_by="XM_011521880.3:80..14659"
                     /db_xref="GeneID:6263"
                     /db_xref="HGNC:HGNC:10485"
                     /db_xref="MIM:180903"
ORIGIN      
        1 maeggegged eiqflrtede vvlqciatih keqrkfclaa eglgnrlcfl eptseakyip
       61 pdlcvcnfvl eqslsvralq emlantgeng gegaaqgggh rtllyghavl lrhsfsgmyl
      121 tclttsrsqt dklafdvglr ehatgeacww tihpaskqrs egekvrigdd lilvsvsser
      181 ylhlsvsngn iqvdasfmqt lwnvhptcsg ssieegyllg ghvvrlfhgh decltipstd
      241 qndsqhrrif yeaggagtra rslwrveplr iswsgsnirw gqafrlrhlt tghylalted
      301 qglilqdrak sdtkstafsf raskelkekl dsshkrdieg mgvpeikygd svcfvqhias
      361 glwvtykaqd aktsrlgplk rkvilhqegh mddgltlqrc qreesqaari irnttalfsq
      421 fvsgnnrtaa pitlpieevl qtlqdliayf qppeeemrhe dkqnklrslk nrqnlfkeeg
      481 mlalvlncid rlnvynsvah fagiareesg mawkeilnll ykllaalirg nrnncaqfsn
      541 nldwliskld rlesssgile vlhciltesp ealnliaegh iksiislldk hgrnhkvldi
      601 lcslclcngv avranqnlic dnllprrnll lqtrlindvt sirpniflgv aegsaqykkw
      661 yfeliidqvd pfltaepthl rvgwasssgy apypgggegw ggngvgddly sygfdglhlw
      721 sgripravas inqhllrsdd vvsccldlgv psisfringq pvqgmfenfn tdglffpvms
      781 fsagvkvrfl mggrhgefkf lppsgyapcy eallpkekmr lepvkeykrd adgirdllgt
      841 tqflsqasfi pcpvdtsqvi lpphlekird rlaenihelw gmnkielgwt fgkirddnkr
      901 qhpclvefsk lpeteknynl qmstetlktl lalgchiahv npaaeedlkk vklpknymms
      961 ngykpapldl sdvkllppqe ilvdklaena hnvwakdrik qgwtygiqqd lknkrnprlv
     1021 pyalldertk ksnrdslrea vrtfvgygyn iepsdqelad savekvsidk irffrversy
     1081 avrsgkwyfe fevvtggdmr vgwarpgcrp dvelgaddqa fvfegnrgqr whqgsgyfgr
     1141 twqpgdvvgc minlddasmi ftlngellit nkgselafad yeiengfvpi cclglsqigr
     1201 mnlgtdastf kfytmcglqe gfepfavnmn rdvamwfskr lptfvnvpkd hphievmrid
     1261 gtmdsppclk vthktfgtqn snadmiycrl smpvechssf shspcldsea fqkrkqmqei
     1321 lshtttqcyy airifagqdp scvwvgwvtp dyhlysekfd lnknctvtvt lgdergrvhe
     1381 svkrsncymv wggdivassq rsnrsnvdle igclvdlamg mlsfsangke lgtcyqvepn
     1441 tkvfpavflq ptstslfqfe lgklknampl saaifrseek npvpqcpprl dvqtiqpvlw
     1501 srmpnsflkv etervserhg wvvqcleplq mmalhipeen rcvdilelce qedlmrfhyh
     1561 tlrlysavca lgnsrvayal cshvdlsqlf yaidnkylpg llrsgfydll isihlasake
     1621 rklmmkneyi ipitsttrni rlfpdeskrh glpgvglrtc lkpgfrfstp cfvvtgedhq
     1681 kqspeiples lrtkalsmlt eavqcsgahi rdpvggsvef qfvpvlklig tllvmgvfdd
     1741 ddvrqillli dpsvfgehsa gteegaekee vtqveekave agekagkeap vkgllqtrlp
     1801 esvklqmcel lsylcdcelq hrveaivafg diyvsklqan qkfrynelmq alnmsaalta
     1861 rktkefrspp qeqinmllnf qlgencpcpe eireelydfh edlllhcgvp leeeeeeeed
     1921 tswtgklcal vykikgppkp ekeqpteeee rcpttlkeli sqtmicwaqe dqiqdselvr
     1981 mmfnllrrqy dsigellqal rktytishts vsdtinllaa lgqirsllsv rmgkeeellm
     2041 inglgdimnn kvfyqhpnlm rvlgmhetvm evmvnvlgte ksqiafpkmv asccrflcyf
     2101 crisrqnqka mfehlsylle nssvglasps mrgstpldva assvmdnnel alsleepdle
     2161 kvvtylagcg lqscpmllak gypdvgwnpi egerylsflr favfvnsesv eenasvvvkl
     2221 lirrpecfgp alrgeggngl laamqgaiki senpaldlps qgykrevtgd deeeeeivhm
     2281 gnaimsfysa lidllgrcap emhliqtgkg eairirsilr slvptedlvg iisiplklps
     2341 lnkdgsvsep dmaanfcpdh kapmvlfldr vygikdqtfl lhllevgflp dlrasasldt
     2401 vslstteaal alnryicsav lplltrcapl fagtehctsl idstlqtiyr lskgrsltka
     2461 qrdtieecll aicnhlrpsm lqqllrrlvf dvpqlneyck mplklltnhy eqcwkyyclp
     2521 sgwgsyglav eeelhltekl fwgifdslsh kkydpdlfrm alpclsaiag alppdyldtr
     2581 itatlekqis vdadgnfdpk pintmnfslp ekleyivtky aehshdkwac dksqsgwkyg
     2641 isldenvkth plirpfktlt ekekeiyrwp areslktmla vgwtvertke gealvqqren
     2701 eklrsvsqan qgnsyspapl dlsnvvlsre lqgmvevvae nyhniwakkk kleleskggg
     2761 shpllvpydt ltakekfkdr ekaqdlfkfl qvngiivsrg mkdmeldass mekrfaykfl
     2821 kkilkyvdsa qefiahleai vssgkteksp rdqeikffak vllplvdqyf tshclyflss
     2881 plkplsssgy ashkekemva glfcklaalv rhrislfgsd sttmvsclhi laqtldtrtv
     2941 mksgselvka glraffenaa edlektsenl klgkfthsrt qikgvsqnin yttvallpil
     3001 tsifehvtqh qfgmdlllgd vqiscyhilc slyslgtgkn iyverqrpal geclaslaaa
     3061 ipvafleptl nrynplsvfn tktprersil gmpdtvedmc pdipqleglm keindlaesg
     3121 arytemphvi evilpmlcny lsywwergpe nlppstgpcc tkvtsehlsl ilgnilkiin
     3181 nnlgideasw mkriavyaqp iiskarpdll rshfiptlek lkkkavktvq eeeqlkadgk
     3241 gdtqeaelli ldefavlcrd lyafypmlir yvdnnrsnwl kspdadsdql frmvaevfil
     3301 wckshnfkre eqnfviqnei nnlafltgds kskmsksggq dqerkktkrr gdlysiqtsl
     3361 ivaalkkmlp iglnmctpgd qelislaksr yshrdtdeev rehlrnnlhl qeksddpavk
     3421 wqlnlykdvl kseepfnpek tvervqrisa avfhleqveq plrskkavwh kllskqrkra
     3481 vvacfrmapl ynlprhkinn fflstfqqvw lekvnektqy drlipilmks pkveeeeeee
     3541 tekqpdplhq iilyfsrnal terskleddp lytsyssmma kscqsgedee ededkektfe
     3601 ekemekqktl yqqarlherg aaemvlqmis askgemspmv vetlklgiai lnggnagvqq
     3661 kmldylkekk dagffqslsg lmqscsvldl naferqnkae glgmvteegt rekvlqndef
     3721 trdlfrflql lceghnsdfq nflrtqmgnt ttvnviistv dyllrlqesi sdfywyysgk
     3781 diidesgqhn fskalavtkq ifnslteyiq gpcignqqsl ahsrlwdavv gflhvfanmq
     3841 mklsqdssqi ellkelldll qdmvvmllsl legnvvngti gkqmvdtlve sstnvemilk
     3901 ffdmflklkd ltssdtfkey dpdgkgiisk kefqkamegq kqytqseidf llscaeaden
     3961 dmfnyvdfvd rfhepakdig fnvavlltnl sehmpndsrl kclldpaesv lnyfepylgr
     4021 ieimggakki ervyfeises srtqwekpqv keskrqfifd vvneggeqek melfvnfced
     4081 tifemqlasq isesdsadrp eeeeededss yvleiageee edgslepasa famacasvkr
     4141 nvtdflkrat lknlrkqyrn vkkmtakelv kvlfsffwml fvglfqllft ilggifqilw
     4201 stvfggglve gaknirvtki lgdmpdptqf gihddtmeae raevmepgit telvhfikge
     4261 kgdtdimsdl fglhpkkegs lkhgpevglg dlseiigkde pptlestvqk krkaqaaemk
     4321 aaneaegkve sekadmedge kedkdkeeeq aeylwtevtk kkkrrcgqkv ekpeaftanf
     4381 fkgleiyqtk llhylarnfy nlrflalfva fainfillfy kvteepleee tedvanlwns
     4441 fndeeeeeam vffvlqestg ymaptlrala iihtiislvc vvgyyclkvp lvvfkrekei
     4501 arklefdgly iteqpseddi kgqwdrlvin tpsfpnnywd kfvkrkvink ygdlygaeri
     4561 aellgldkna ldfspveetk aeaaslvswl ssidmkyhiw klgvvftdns flylawyttm
     4621 svlghynnff faahlldiam gfktlrtils svthngkqlv ltvgllavvv ylytvvafnf
     4681 frkfynksed ddepdmkcdd mmtcylfhmy vgvragggig deiedpagdp yemyrivfdi
     4741 tffffvivil laiiqgliid afgelrdqqe qvredmetkc ficgigndyf dttphgfeth
     4801 tlqehnlany lfflmylink detehtgqes yvwkmyqerc wdffpagdcf rkqyedqlg
//
LOCUS       XP_016877963            4859 aa            linear   PRI 05-AUG-2025
DEFINITION  ryanodine receptor 3 isoform X9 [Homo sapiens].
ACCESSION   XP_016877963
VERSION     XP_016877963.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022474.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4859
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4859
                     /product="ryanodine receptor 3 isoform X9"
                     /calculated_mol_wt=550851
     Region          11..205
                     /region_name="Ins145_P3_rec"
                     /note="Inositol 1,4,5-trisphosphate/ryanodine receptor;
                     pfam08709"
                     /db_xref="CDD:462572"
     Region          209..398
                     /region_name="beta-trefoil_MIR_RyR3"
                     /note="MIR domain, beta-trefoil fold, found in ryanodine
                     receptor 3 (RyR3) and similar proteins; cd23292"
                     /db_xref="CDD:467763"
     Site            384
                     /site_type="other"
                     /note="putative homotetramer interface [polypeptide
                     binding]"
                     /db_xref="CDD:467763"
     Region          435..614
                     /region_name="RYDR_ITPR"
                     /note="RIH domain; pfam01365"
                     /db_xref="CDD:460175"
     Region          634..785
                     /region_name="SPRY1_RyR"
                     /note="SPRY domain 1 (SPRY1) of ryanodine receptor (RyR);
                     cd12877"
                     /db_xref="CDD:240457"
     Region          842..930
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          956..1045
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          1065..1197
                     /region_name="SPRY2_RyR"
                     /note="SPRY domain 2 (SPRY2) of ryanodine receptor (RyR);
                     cd12878"
                     /db_xref="CDD:240458"
     Region          1317..1455
                     /region_name="SPRY3_RyR"
                     /note="SPRY domain 3 (SPRY3) of ryanodine receptor (RyR);
                     cd12879"
                     /db_xref="CDD:293937"
     Region          2016..2226
                     /region_name="RYDR_ITPR"
                     /note="RIH domain; pfam01365"
                     /db_xref="CDD:460175"
     Region          2591..2680
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          2709..2788
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          3716..3833
                     /region_name="RIH_assoc"
                     /note="RyR and IP3R Homology associated; pfam08454"
                     /db_xref="CDD:462482"
     Region          3917..3972
                     /region_name="EF-hand_7"
                     /note="EF-hand domain pair; pfam13499"
                     /db_xref="CDD:463900"
     Region          4223..4493
                     /region_name="RR_TM4-6"
                     /note="Ryanodine Receptor TM 4-6; pfam06459"
                     /db_xref="CDD:461918"
     Region          <4610..4770
                     /region_name="Ion_trans"
                     /note="Ion transport protein; pfam00520"
                     /db_xref="CDD:459842"
     CDS             1..4859
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /coded_by="XM_017022474.2:258..14837"
                     /db_xref="GeneID:6263"
                     /db_xref="HGNC:HGNC:10485"
                     /db_xref="MIM:180903"
ORIGIN      
        1 mhslhlrsee edevvlqcia tihkeqrkfc laaeglgnrl cfleptseak yippdlcvcn
       61 fvleqslsvr alqemlantg enggegaaqg gghrtllygh avllrhsfsg myltclttsr
      121 sqtdklafdv glrehatgea cwwtihpask qrsegekvri gddlilvsvs serylhlsvs
      181 ngniqvdasf mqtlwnvhpt csgssieegy llgghvvrlf hghdecltip stdqndsqhr
      241 rifyeaggag trarslwrve plriswsgsn irwgqafrlr hlttghylal tedqglilqd
      301 raksdtksta fsfraskelk ekldsshkrd iegmgvpeik ygdsvcfvqh iasglwvtyk
      361 aqdaktsrlg plkrkvilhq eghmddgltl qrcqreesqa ariirnttal fsqfvsgnnr
      421 taapitlpie evlqtlqdli ayfqppeeem rhedkqnklr slknrqnlfk eegmlalvln
      481 cidrlnvyns vahfagiare esgmawkeil nllykllaal irgnrnncaq fsnnldwlis
      541 kldrlesssg ilevlhcilt espealnlia eghiksiisl ldkhgrnhkv ldilcslclc
      601 ngvavranqn licdnllprr nlllqtrlin dvtsirpnif lgvaegsaqy kkwyfeliid
      661 qvdpfltaep thlrvgwass sgyapypggg egwggngvgd dlysygfdgl hlwsgripra
      721 vasinqhllr sddvvsccld lgvpsisfri ngqpvqgmfe nfntdglffp vmsfsagvkv
      781 rflmggrhge fkflppsgya pcyeallpke kmrlepvkey krdadgirdl lgttqflsqa
      841 sfipcpvdts qvilpphlek irdrlaenih elwgmnkiel gwtfgkirdd nkrqhpclve
      901 fsklpetekn ynlqmstetl ktllalgchi ahvnpaaeed lkkvklpkny mmsngykpap
      961 ldlsdvkllp pqeilvdkla enahnvwakd rikqgwtygi qqdlknkrnp rlvpyallde
     1021 rtkksnrdsl reavrtfvgy gyniepsdqe ladsavekvs idkirffrve rsyavrsgkw
     1081 yfefevvtgg dmrvgwarpg crpdvelgad dqafvfegnr gqrwhqgsgy fgrtwqpgdv
     1141 vgcminldda smiftlngel litnkgsela fadyeiengf vpicclglsq igrmnlgtda
     1201 stfkfytmcg lqegfepfav nmnrdvamwf skrlptfvnv pkdhphievm ridgtmdspp
     1261 clkvthktfg tqnsnadmiy crlsmpvech ssfshspcld seafqkrkqm qeilshtttq
     1321 cyyairifag qdpscvwvgw vtpdyhlyse kfdlnknctv tvtlgdergr vhesvkrsnc
     1381 ymvwggdiva ssqrsnrsnv dleigclvdl amgmlsfsan gkelgtcyqv epntkvfpav
     1441 flqptstslf qfelgklkna mplsaaifrs eeknpvpqcp prldvqtiqp vlwsrmpnsf
     1501 lkvetervse rhgwvvqcle plqmmalhip eenrcvdile lceqedlmrf hyhtlrlysa
     1561 vcalgnsrva yalcshvdls qlfyaidnky lpgllrsgfy dllisihlas akerklmmkn
     1621 eyiipitstt rnirlfpdes krhglpgvgl rtclkpgfrf stpcfvvtge dhqkqspeip
     1681 leslrtkals mlteavqcsg ahirdpvggs vefqfvpvlk ligtllvmgv fddddvrqil
     1741 llidpsvfge hsagteegae keevtqveek aveagekagk eapvkgllqt rlpesvklqm
     1801 cellsylcdc elqhrveaiv afgdiyvskl qanqkfryne lmqalnmsaa ltarktkefr
     1861 sppqeqinml lnfqlgencp cpeeireely dfhedlllhc gvpleeeeee eedtswtgkl
     1921 calvykikgp pkpekeqpte eeercpttlk elisqtmicw aqedqiqdse lvrmmfnllr
     1981 rqydsigell qalrktytis htsvsdtinl laalgqirsl lsvrmgkeee llminglgdi
     2041 mnnkvfyqhp nlmrvlgmhe tvmevmvnvl gteksqiafp kmvasccrfl cyfcrisrqn
     2101 qkamfehlsy llenssvgla spsmrgstpl dvaassvmdn nelalsleep dlekvvtyla
     2161 gcglqscpml lakgypdvgw npiegeryls flrfavfvns esveenasvv vkllirrpec
     2221 fgpalrgegg ngllaamqga ikisenpald lpsqgykrev stgddeeeee ivhmgnaims
     2281 fysalidllg rcapemhliq tgkgeairir silrslvpte dlvgiisipl klpslnkdgs
     2341 vsepdmaanf cpdhkapmvl fldrvygikd qtfllhllev gflpdlrasa sldtvslstt
     2401 eaalalnryi csavlplltr caplfagteh ctslidstlq tiyrlskgrs ltkaqrdtie
     2461 ecllaicnhl rpsmlqqllr rlvfdvpqln eyckmplkll tnhyeqcwky yclpsgwgsy
     2521 glaveeelhl teklfwgifd slshkkydpd lfrmalpcls aiagalppdy ldtritatle
     2581 kqisvdadgn fdpkpintmn fslpekleyi vtkyaehshd kwacdksqsg wkygislden
     2641 vkthplirpf ktltekekei yrwpareslk tmlavgwtve rtkegealvq qreneklrsv
     2701 sqanqgnsys papldlsnvv lsrelqgmve vvaenyhniw akkkkleles kgggshpllv
     2761 pydtltakek fkdrekaqdl fkflqvngii vsrgmkdmel dassmekrfa ykflkkilky
     2821 vdsaqefiah leaivssgkt eksprdqeik ffakvllplv dqyftshcly flssplkpls
     2881 ssgyashkek emvaglfckl aalvrhrisl fgsdsttmvs clhilaqtld trtvmksgse
     2941 lvkaglraff enaaedlekt senlklgkft hsrtqikgvs qninyttval lpiltsifeh
     3001 vtqhqfgmdl llgdvqiscy hilcslyslg tgkniyverq rpalgeclas laaaipvafl
     3061 eptlnrynpl svfntktpre rsilgmpdtv edmcpdipql eglmkeindl aesgarytem
     3121 phvievilpm lcnylsywwe rgpenlppst gpcctkvtse hlslilgnil kiinnnlgid
     3181 easwmkriav yaqpiiskar pdllrshfip tleklkkkav ktvqeeeqlk adgkgdtqea
     3241 ellildefav lcrdlyafyp mliryvdnnr snwlkspdad sdqlfrmvae vfilwckshn
     3301 fkreeqnfvi qneinnlafl tgdskskmsk sggqdqerkk tkrrgdlysi qtslivaalk
     3361 kmlpiglnmc tpgdqelisl aksryshrdt deevrehlrn nlhlqeksdd pavkwqlnly
     3421 kdvlkseepf npektvervq risaavfhle qveqplrskk avwhkllskq rkravvacfr
     3481 maplynlprh kinnfflstf qqvwlekvne ktqydrlipi lmkspkveee eeeetekqpd
     3541 plhqiilyfs rnalterskl eddplytsys smmakscqsg edeeededke ktfeekemek
     3601 qktlyqqarl hergaaemvl qmisaskgem spmvvetlkl giailnggna gvqqkmldyl
     3661 kekkdagffq slsglmqscs vldlnaferq nkaeglgmvt eegtlivrer gekvlqndef
     3721 trdlfrflql lceghnsdfq nflrtqmgnt ttvnviistv dyllrlqesi sdfywyysgk
     3781 diidesgqhn fskalavtkq ifnslteyiq gpcignqqsl ahsrlwdavv gflhvfanmq
     3841 mklsqdssqi ellkelldll qdmvvmllsl legnvvngti gkqmvdtlve sstnvemilk
     3901 ffdmflklkd ltssdtfkey dpdgkgiisk kefqkamegq kqytqseidf llscaeaden
     3961 dmfnyvdfvd rfhepakdig fnvavlltnl sehmpndsrl kclldpaesv lnyfepylgr
     4021 ieimggakki ervyfeises srtqwekpqv keskrqfifd vvneggeqek melfvnfced
     4081 tifemqlasq isesdsadrp eeeeededss yvleiageee edgslepasa famacasvkr
     4141 nvtdflkrat lknlrkqyrn vkkmtakelv kvlfsffwml fvglfqllft ilggifqilw
     4201 stvfggglve gaknirvtki lgdmpdptqf gihddtmeae raevmepgit telvhfikge
     4261 kgdtdimsdl fglhpkkegs lkhgpevglg dlseiigkde pptlestvqk krkaqaaemk
     4321 aaneaegkve sekadmedge kedkdkeeeq aeylwtevtk kkkrrcgqkv ekpeaftanf
     4381 fkgleiyqtk llhylarnfy nlrflalfva fainfillfy kvteepleee tedvanlwns
     4441 fndeeeeeam vffvlqestg ymaptlrala iihtiislvc vvgyyclkvp lvvfkrekei
     4501 arklefdgly iteqpseddi kgqwdrlvin tpsfpnnywd kfvkrkvink ygdlygaeri
     4561 aellgldkna ldfspveetk aeaaslvswl ssidmkyhiw klgvvftdns flylawyttm
     4621 svlghynnff faahlldiam gfktlrtils svthngkqlv ltvgllavvv ylytvvafnf
     4681 frkfynksed ddepdmkcdd mmtcylfhmy vgvragggig deiedpagdp yemyrivfdi
     4741 tffffvivil laiiqgliid afgelrdqqe qvredmetkc ficgigndyf dttphgfeth
     4801 tlqehnlany lfflmylink detehtgqes yvwkmyqerc wdffpagdcf rkqyedqlg
//
LOCUS       XP_047288887            4838 aa            linear   PRI 05-AUG-2025
DEFINITION  ryanodine receptor 3 isoform X10 [Homo sapiens].
ACCESSION   XP_047288887
VERSION     XP_047288887.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432931.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4838
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4838
                     /product="ryanodine receptor 3 isoform X10"
                     /calculated_mol_wt=547912
     Region          14..212
                     /region_name="Ins145_P3_rec"
                     /note="Inositol 1,4,5-trisphosphate/ryanodine receptor;
                     pfam08709"
                     /db_xref="CDD:462572"
     Region          216..405
                     /region_name="beta-trefoil_MIR_RyR3"
                     /note="MIR domain, beta-trefoil fold, found in ryanodine
                     receptor 3 (RyR3) and similar proteins; cd23292"
                     /db_xref="CDD:467763"
     Site            391
                     /site_type="other"
                     /note="putative homotetramer interface [polypeptide
                     binding]"
                     /db_xref="CDD:467763"
     Region          442..621
                     /region_name="RYDR_ITPR"
                     /note="RIH domain; pfam01365"
                     /db_xref="CDD:460175"
     Region          641..792
                     /region_name="SPRY1_RyR"
                     /note="SPRY domain 1 (SPRY1) of ryanodine receptor (RyR);
                     cd12877"
                     /db_xref="CDD:240457"
     Region          849..937
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          963..1052
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          1072..1204
                     /region_name="SPRY2_RyR"
                     /note="SPRY domain 2 (SPRY2) of ryanodine receptor (RyR);
                     cd12878"
                     /db_xref="CDD:240458"
     Region          1324..1462
                     /region_name="SPRY3_RyR"
                     /note="SPRY domain 3 (SPRY3) of ryanodine receptor (RyR);
                     cd12879"
                     /db_xref="CDD:293937"
     Region          2023..2233
                     /region_name="RYDR_ITPR"
                     /note="RIH domain; pfam01365"
                     /db_xref="CDD:460175"
     Region          2598..2687
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          2716..2795
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          3723..3840
                     /region_name="RIH_assoc"
                     /note="RyR and IP3R Homology associated; pfam08454"
                     /db_xref="CDD:462482"
     Region          3924..3979
                     /region_name="EF-hand_7"
                     /note="EF-hand domain pair; pfam13499"
                     /db_xref="CDD:463900"
     Region          4230..4500
                     /region_name="RR_TM4-6"
                     /note="Ryanodine Receptor TM 4-6; pfam06459"
                     /db_xref="CDD:461918"
     Region          <4617..4777
                     /region_name="Ion_trans"
                     /note="Ion transport protein; pfam00520"
                     /db_xref="CDD:459842"
     CDS             1..4838
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /coded_by="XM_047432931.1:80..14596"
                     /db_xref="GeneID:6263"
                     /db_xref="HGNC:HGNC:10485"
                     /db_xref="MIM:180903"
ORIGIN      
        1 maeggegged eiqflrtede vvlqciatih keqrkfclaa eglgnrlcfl eptseakyip
       61 pdlcvcnfvl eqslsvralq emlantgeng gegaaqgggh rtllyghavl lrhsfsgmyl
      121 tclttsrsqt dklafdvglr ehatgeacww tihpaskqrs egekvrigdd lilvsvsser
      181 ylhlsvsngn iqvdasfmqt lwnvhptcsg ssieegyllg ghvvrlfhgh decltipstd
      241 qndsqhrrif yeaggagtra rslwrveplr iswsgsnirw gqafrlrhlt tghylalted
      301 qglilqdrak sdtkstafsf raskelkekl dsshkrdieg mgvpeikygd svcfvqhias
      361 glwvtykaqd aktsrlgplk rkvilhqegh mddgltlqrc qreesqaari irnttalfsq
      421 fvsgnnrtaa pitlpieevl qtlqdliayf qppeeemrhe dkqnklrslk nrqnlfkeeg
      481 mlalvlncid rlnvynsvah fagiareesg mawkeilnll ykllaalirg nrnncaqfsn
      541 nldwliskld rlesssgile vlhciltesp ealnliaegh iksiislldk hgrnhkvldi
      601 lcslclcngv avranqnlic dnllprrnll lqtrlindvt sirpniflgv aegsaqykkw
      661 yfeliidqvd pfltaepthl rvgwasssgy apypgggegw ggngvgddly sygfdglhlw
      721 sgripravas inqhllrsdd vvsccldlgv psisfringq pvqgmfenfn tdglffpvms
      781 fsagvkvrfl mggrhgefkf lppsgyapcy eallpkekmr lepvkeykrd adgirdllgt
      841 tqflsqasfi pcpvdtsqvi lpphlekird rlaenihelw gmnkielgwt fgkirddnkr
      901 qhpclvefsk lpeteknynl qmstetlktl lalgchiahv npaaeedlkk vklpknymms
      961 ngykpapldl sdvkllppqe ilvdklaena hnvwakdrik qgwtygiqqd lknkrnprlv
     1021 pyalldertk ksnrdslrea vrtfvgygyn iepsdqelad savekvsidk irffrversy
     1081 avrsgkwyfe fevvtggdmr vgwarpgcrp dvelgaddqa fvfegnrgqr whqgsgyfgr
     1141 twqpgdvvgc minlddasmi ftlngellit nkgselafad yeiengfvpi cclglsqigr
     1201 mnlgtdastf kfytmcglqe gfepfavnmn rdvamwfskr lptfvnvpkd hphievmrid
     1261 gtmdsppclk vthktfgtqn snadmiycrl smpvechssf shspcldsea fqkrkqmqei
     1321 lshtttqcyy airifagqdp scvwvgwvtp dyhlysekfd lnknctvtvt lgdergrvhe
     1381 svkrsncymv wggdivassq rsnrsnvdle igclvdlamg mlsfsangke lgtcyqvepn
     1441 tkvfpavflq ptstslfqfe lgklknampl saaifrseek npvpqcpprl dvqtiqpvlw
     1501 srmpnsflkv etervserhg wvvqcleplq mmalhipeen rcvdilelce qedlmrfhyh
     1561 tlrlysavca lgnsrvayal cshvdlsqlf yaidnkylpg llrsgfydll isihlasake
     1621 rklmmkneyi ipitsttrni rlfpdeskrh glpgvglrtc lkpgfrfstp cfvvtgedhq
     1681 kqspeiples lrtkalsmlt eavqcsgahi rdpvggsvef qfvpvlklig tllvmgvfdd
     1741 ddvrqillli dpsvfgehsa gteegaekee vtqveekave agekagkeap vkgllqtrlp
     1801 esvklqmcel lsylcdcelq hrveaivafg diyvsklqan qkfrynelmq alnmsaalta
     1861 rktkefrspp qeqinmllnf qlgencpcpe eireelydfh edlllhcgvp leeeeeeeed
     1921 tswtgklcal vykikgppkp ekeqpteeee rcpttlkeli sqtmicwaqe dqiqdselvr
     1981 mmfnllrrqy dsigellqal rktytishts vsdtinllaa lgqirsllsv rmgkeeellm
     2041 inglgdimnn kvfyqhpnlm rvlgmhetvm evmvnvlgte ksqiafpkmv asccrflcyf
     2101 crisrqnqka mfehlsylle nssvglasps mrgstpldva assvmdnnel alsleepdle
     2161 kvvtylagcg lqscpmllak gypdvgwnpi egerylsflr favfvnsesv eenasvvvkl
     2221 lirrpecfgp alrgeggngl laamqgaiki senpaldlps qgykrevstg ddeeeeeivh
     2281 mgnaimsfys alidllgrca pemhliqtgk geairirsil rslvptedlv giisiplklp
     2341 slnkdgsvse pdmaanfcpd hkapmvlfld rvygikdqtf llhllevgfl pdlrasasld
     2401 tvslstteaa lalnryicsa vlplltrcap lfagtehcts lidstlqtiy rlskgrsltk
     2461 aqrdtieecl laicnhlrps mlqqllrrlv fdvpqlneyc kmplklltnh yeqcwkyycl
     2521 psgwgsygla veeelhltek lfwgifdsls hkkydpdlfr malpclsaia galppdyldt
     2581 ritatlekqi svdadgnfdp kpintmnfsl pekleyivtk yaehshdkwa cdksqsgwky
     2641 gisldenvkt hplirpfktl tekekeiyrw pareslktml avgwtvertk egealvqqre
     2701 neklrsvsqa nqgnsyspap ldlsnvvlsr elqgmvevva enyhniwakk kkleleskgg
     2761 gshpllvpyd tltakekfkd rekaqdlfkf lqvngiivsr gmkdmeldas smekrfaykf
     2821 lkkilkyvds aqefiahlea ivssgkteks prdqeikffa kvllplvdqy ftshclyfls
     2881 splkplsssg yashkekemv aglfcklaal vrhrislfgs dsttmvsclh ilaqtldtrt
     2941 vmksgselvk aglraffena aedlektsen lklgkfthsr tqikgvsqni nyttvallpi
     3001 ltsifehvtq hqfgmdlllg dvqiscyhil cslyslgtgk niyverqrpa lgeclaslaa
     3061 aipvaflept lnrynplsvf ntktprersi lgmpdtvedm cpdipqlegl mkeindlaes
     3121 garytemphv ievilpmlcn ylsywwergp enlppstgpc ctkvtsehls lilgnilkii
     3181 nnnlgideas wmkriavyaq piiskarpdl lrshfiptle klkkkavktv qeeeqlkadg
     3241 kgdtqeaell ildefavlcr dlyafypmli ryvdnnrsnw lkspdadsdq lfrmvaevfi
     3301 lwckshnfkr eeqnfviqne innlafltgd skskmsksgg qdqerkktkr rgdlysiqts
     3361 livaalkkml piglnmctpg dqelislaks ryshrdtdee vrehlrnnlh lqeksddpav
     3421 kwqlnlykdv lkseepfnpe ktvervqris aavfhleqve qplrskkavw hkllskqrkr
     3481 avvacfrmap lynlprhkin nfflstfqqv wlekvnektq ydrlipilmk spkveeeeee
     3541 etekqpdplh qiilyfsrna lterskledd plytsyssmm akscqsgede eededkektf
     3601 eekemekqkt lyqqarlher gaaemvlqmi saskgemspm vvetlklgia ilnggnagvq
     3661 qkmldylkek kdagffqsls glmqscsvld lnaferqnka eglgmvteeg tlivrergek
     3721 vlqndeftrd lfrflqllce ghnsdfqnfl rtqmgntttv nviistvdyl lrlqesisdf
     3781 ywyysgkdii desgqhnfsk alavtkqifn slteyiqgpc ignqqslahs rlwdavvgfl
     3841 hvfanmqmkl sqdssqiell kelldllqdm vvmllslleg nvvngtigkq mvdtlvesst
     3901 nvemilkffd mflklkdlts sdtfkeydpd gkgiiskkef qkamegqkqy tqseidflls
     3961 caeadendmf nyvdfvdrfh epakdigfnv avlltnlseh mpndsrlkcl ldpaesvlny
     4021 fepylgriei mggakkierv yfeisessrt qwekpqvkes krqfifdvvn eggeqekmel
     4081 fvnfcedtif emqlasqise sdsadrpeee eededssyvl eiageeeedg slepasafam
     4141 acasvkrnvt dflkratlkn lrkqyrnvkk mtakelvkvl fsffwmlfvg lfqllftilg
     4201 gifqilwstv fggglvegak nirvtkilgd mpdptqfgih ddtmeaerae vmepgittel
     4261 vhfikgekgd tdimsdlfgl hpkkegslkh gpevglgdls eiigkdeppt lestvqkkrk
     4321 aqaaemkaan eaegkvesek admedgeked kdkeeeqaey lwtevtkkkk rrcgqkvekp
     4381 eaftanffkg leiyqtkllh ylarnfynlr flalfvafai nfillfykvt eepleeeted
     4441 vanlwnsfnd eeeeeamvff vlqestgyma ptlralaiih tiislvcvvg yyclkvplvv
     4501 fkrekeiark lefdglyite qpseddikgq wdrlvintps fpnnywdkfv krkvinkygd
     4561 lygaeriael lgldknaldf spveetkaea aslvswlssi dmkyhiwklg vvftdnsfly
     4621 lawyttmsvl ghynnfffaa hlldiamgfk tlrtilssvt hngkqlvltv gllavvvyly
     4681 tvvafnffrk fynkseddde pdmkcddmmt cylfhmyvgv ragggigdei edpagdpyem
     4741 yrivfditff ffvivillai iqgliidafg elrdqqeqvr edmetkcfic gigndyfdtt
     4801 phgfethtlq ehnlanylff lmylinkdet ehtgqvrn
//
LOCUS       XP_016877964            4837 aa            linear   PRI 05-AUG-2025
DEFINITION  ryanodine receptor 3 isoform X11 [Homo sapiens].
ACCESSION   XP_016877964
VERSION     XP_016877964.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022475.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4837
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4837
                     /product="ryanodine receptor 3 isoform X11"
                     /calculated_mol_wt=547870
     Region          14..212
                     /region_name="Ins145_P3_rec"
                     /note="Inositol 1,4,5-trisphosphate/ryanodine receptor;
                     pfam08709"
                     /db_xref="CDD:462572"
     Region          216..405
                     /region_name="beta-trefoil_MIR_RyR3"
                     /note="MIR domain, beta-trefoil fold, found in ryanodine
                     receptor 3 (RyR3) and similar proteins; cd23292"
                     /db_xref="CDD:467763"
     Site            391
                     /site_type="other"
                     /note="putative homotetramer interface [polypeptide
                     binding]"
                     /db_xref="CDD:467763"
     Region          442..621
                     /region_name="RYDR_ITPR"
                     /note="RIH domain; pfam01365"
                     /db_xref="CDD:460175"
     Region          641..792
                     /region_name="SPRY1_RyR"
                     /note="SPRY domain 1 (SPRY1) of ryanodine receptor (RyR);
                     cd12877"
                     /db_xref="CDD:240457"
     Region          849..937
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          963..1052
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          1072..1204
                     /region_name="SPRY2_RyR"
                     /note="SPRY domain 2 (SPRY2) of ryanodine receptor (RyR);
                     cd12878"
                     /db_xref="CDD:240458"
     Region          1324..1462
                     /region_name="SPRY3_RyR"
                     /note="SPRY domain 3 (SPRY3) of ryanodine receptor (RyR);
                     cd12879"
                     /db_xref="CDD:293937"
     Region          2023..2233
                     /region_name="RYDR_ITPR"
                     /note="RIH domain; pfam01365"
                     /db_xref="CDD:460175"
     Region          2598..2687
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          2716..2795
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          3723..3840
                     /region_name="RIH_assoc"
                     /note="RyR and IP3R Homology associated; pfam08454"
                     /db_xref="CDD:462482"
     Region          3924..3979
                     /region_name="EF-hand_7"
                     /note="EF-hand domain pair; pfam13499"
                     /db_xref="CDD:463900"
     Region          4230..4471
                     /region_name="RR_TM4-6"
                     /note="Ryanodine Receptor TM 4-6; pfam06459"
                     /db_xref="CDD:461918"
     Region          <4588..4748
                     /region_name="Ion_trans"
                     /note="Ion transport protein; pfam00520"
                     /db_xref="CDD:459842"
     CDS             1..4837
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /coded_by="XM_017022475.2:80..14593"
                     /db_xref="GeneID:6263"
                     /db_xref="HGNC:HGNC:10485"
                     /db_xref="MIM:180903"
ORIGIN      
        1 maeggegged eiqflrtede vvlqciatih keqrkfclaa eglgnrlcfl eptseakyip
       61 pdlcvcnfvl eqslsvralq emlantgeng gegaaqgggh rtllyghavl lrhsfsgmyl
      121 tclttsrsqt dklafdvglr ehatgeacww tihpaskqrs egekvrigdd lilvsvsser
      181 ylhlsvsngn iqvdasfmqt lwnvhptcsg ssieegyllg ghvvrlfhgh decltipstd
      241 qndsqhrrif yeaggagtra rslwrveplr iswsgsnirw gqafrlrhlt tghylalted
      301 qglilqdrak sdtkstafsf raskelkekl dsshkrdieg mgvpeikygd svcfvqhias
      361 glwvtykaqd aktsrlgplk rkvilhqegh mddgltlqrc qreesqaari irnttalfsq
      421 fvsgnnrtaa pitlpieevl qtlqdliayf qppeeemrhe dkqnklrslk nrqnlfkeeg
      481 mlalvlncid rlnvynsvah fagiareesg mawkeilnll ykllaalirg nrnncaqfsn
      541 nldwliskld rlesssgile vlhciltesp ealnliaegh iksiislldk hgrnhkvldi
      601 lcslclcngv avranqnlic dnllprrnll lqtrlindvt sirpniflgv aegsaqykkw
      661 yfeliidqvd pfltaepthl rvgwasssgy apypgggegw ggngvgddly sygfdglhlw
      721 sgripravas inqhllrsdd vvsccldlgv psisfringq pvqgmfenfn tdglffpvms
      781 fsagvkvrfl mggrhgefkf lppsgyapcy eallpkekmr lepvkeykrd adgirdllgt
      841 tqflsqasfi pcpvdtsqvi lpphlekird rlaenihelw gmnkielgwt fgkirddnkr
      901 qhpclvefsk lpeteknynl qmstetlktl lalgchiahv npaaeedlkk vklpknymms
      961 ngykpapldl sdvkllppqe ilvdklaena hnvwakdrik qgwtygiqqd lknkrnprlv
     1021 pyalldertk ksnrdslrea vrtfvgygyn iepsdqelad savekvsidk irffrversy
     1081 avrsgkwyfe fevvtggdmr vgwarpgcrp dvelgaddqa fvfegnrgqr whqgsgyfgr
     1141 twqpgdvvgc minlddasmi ftlngellit nkgselafad yeiengfvpi cclglsqigr
     1201 mnlgtdastf kfytmcglqe gfepfavnmn rdvamwfskr lptfvnvpkd hphievmrid
     1261 gtmdsppclk vthktfgtqn snadmiycrl smpvechssf shspcldsea fqkrkqmqei
     1321 lshtttqcyy airifagqdp scvwvgwvtp dyhlysekfd lnknctvtvt lgdergrvhe
     1381 svkrsncymv wggdivassq rsnrsnvdle igclvdlamg mlsfsangke lgtcyqvepn
     1441 tkvfpavflq ptstslfqfe lgklknampl saaifrseek npvpqcpprl dvqtiqpvlw
     1501 srmpnsflkv etervserhg wvvqcleplq mmalhipeen rcvdilelce qedlmrfhyh
     1561 tlrlysavca lgnsrvayal cshvdlsqlf yaidnkylpg llrsgfydll isihlasake
     1621 rklmmkneyi ipitsttrni rlfpdeskrh glpgvglrtc lkpgfrfstp cfvvtgedhq
     1681 kqspeiples lrtkalsmlt eavqcsgahi rdpvggsvef qfvpvlklig tllvmgvfdd
     1741 ddvrqillli dpsvfgehsa gteegaekee vtqveekave agekagkeap vkgllqtrlp
     1801 esvklqmcel lsylcdcelq hrveaivafg diyvsklqan qkfrynelmq alnmsaalta
     1861 rktkefrspp qeqinmllnf qlgencpcpe eireelydfh edlllhcgvp leeeeeeeed
     1921 tswtgklcal vykikgppkp ekeqpteeee rcpttlkeli sqtmicwaqe dqiqdselvr
     1981 mmfnllrrqy dsigellqal rktytishts vsdtinllaa lgqirsllsv rmgkeeellm
     2041 inglgdimnn kvfyqhpnlm rvlgmhetvm evmvnvlgte ksqiafpkmv asccrflcyf
     2101 crisrqnqka mfehlsylle nssvglasps mrgstpldva assvmdnnel alsleepdle
     2161 kvvtylagcg lqscpmllak gypdvgwnpi egerylsflr favfvnsesv eenasvvvkl
     2221 lirrpecfgp alrgeggngl laamqgaiki senpaldlps qgykrevstg ddeeeeeivh
     2281 mgnaimsfys alidllgrca pemhliqtgk geairirsil rslvptedlv giisiplklp
     2341 slnkdgsvse pdmaanfcpd hkapmvlfld rvygikdqtf llhllevgfl pdlrasasld
     2401 tvslstteaa lalnryicsa vlplltrcap lfagtehcts lidstlqtiy rlskgrsltk
     2461 aqrdtieecl laicnhlrps mlqqllrrlv fdvpqlneyc kmplklltnh yeqcwkyycl
     2521 psgwgsygla veeelhltek lfwgifdsls hkkydpdlfr malpclsaia galppdyldt
     2581 ritatlekqi svdadgnfdp kpintmnfsl pekleyivtk yaehshdkwa cdksqsgwky
     2641 gisldenvkt hplirpfktl tekekeiyrw pareslktml avgwtvertk egealvqqre
     2701 neklrsvsqa nqgnsyspap ldlsnvvlsr elqgmvevva enyhniwakk kkleleskgg
     2761 gshpllvpyd tltakekfkd rekaqdlfkf lqvngiivsr gmkdmeldas smekrfaykf
     2821 lkkilkyvds aqefiahlea ivssgkteks prdqeikffa kvllplvdqy ftshclyfls
     2881 splkplsssg yashkekemv aglfcklaal vrhrislfgs dsttmvsclh ilaqtldtrt
     2941 vmksgselvk aglraffena aedlektsen lklgkfthsr tqikgvsqni nyttvallpi
     3001 ltsifehvtq hqfgmdlllg dvqiscyhil cslyslgtgk niyverqrpa lgeclaslaa
     3061 aipvaflept lnrynplsvf ntktprersi lgmpdtvedm cpdipqlegl mkeindlaes
     3121 garytemphv ievilpmlcn ylsywwergp enlppstgpc ctkvtsehls lilgnilkii
     3181 nnnlgideas wmkriavyaq piiskarpdl lrshfiptle klkkkavktv qeeeqlkadg
     3241 kgdtqeaell ildefavlcr dlyafypmli ryvdnnrsnw lkspdadsdq lfrmvaevfi
     3301 lwckshnfkr eeqnfviqne innlafltgd skskmsksgg qdqerkktkr rgdlysiqts
     3361 livaalkkml piglnmctpg dqelislaks ryshrdtdee vrehlrnnlh lqeksddpav
     3421 kwqlnlykdv lkseepfnpe ktvervqris aavfhleqve qplrskkavw hkllskqrkr
     3481 avvacfrmap lynlprhkin nfflstfqqv wlekvnektq ydrlipilmk spkveeeeee
     3541 etekqpdplh qiilyfsrna lterskledd plytsyssmm akscqsgede eededkektf
     3601 eekemekqkt lyqqarlher gaaemvlqmi saskgemspm vvetlklgia ilnggnagvq
     3661 qkmldylkek kdagffqsls glmqscsvld lnaferqnka eglgmvteeg tlivrergek
     3721 vlqndeftrd lfrflqllce ghnsdfqnfl rtqmgntttv nviistvdyl lrlqesisdf
     3781 ywyysgkdii desgqhnfsk alavtkqifn slteyiqgpc ignqqslahs rlwdavvgfl
     3841 hvfanmqmkl sqdssqiell kelldllqdm vvmllslleg nvvngtigkq mvdtlvesst
     3901 nvemilkffd mflklkdlts sdtfkeydpd gkgiiskkef qkamegqkqy tqseidflls
     3961 caeadendmf nyvdfvdrfh epakdigfnv avlltnlseh mpndsrlkcl ldpaesvlny
     4021 fepylgriei mggakkierv yfeisessrt qwekpqvkes krqfifdvvn eggeqekmel
     4081 fvnfcedtif emqlasqise sdsadrpeee eededssyvl eiageeeedg slepasafam
     4141 acasvkrnvt dflkratlkn lrkqyrnvkk mtakelvkvl fsffwmlfvg lfqllftilg
     4201 gifqilwstv fggglvegak nirvtkilgd mpdptqfgih ddtmeaerae vmepgittel
     4261 vhfikgekgd tdimsdlfgl hpkkegslkh gpevglgdls eiigkdeppt lestvqkkrk
     4321 aqaaemkaan eaegkvesek admedgeked kdkeeeqaey lwtevtkkkk rrcgqkvekp
     4381 eaftanffkg leiyqtkllv teepleeete dvanlwnsfn deeeeeamvf fvlqestgym
     4441 aptlralaii htiislvcvv gyyclkvplv vfkrekeiar klefdglyit eqpseddikg
     4501 qwdrlvintp sfpnnywdkf vkrkvinkyg dlygaeriae llgldknald fspveetkae
     4561 aaslvswlss idmkyhiwkl gvvftdnsfl ylawyttmsv lghynnfffa ahlldiamgf
     4621 ktlrtilssv thngkqlvlt vgllavvvyl ytvvafnffr kfynkseddd epdmkcddmm
     4681 tcylfhmyvg vragggigde iedpagdpye myrivfditf fffvivilla iiqgliidaf
     4741 gelrdqqeqv redmetkcfi cgigndyfdt tphgfethtl qehnlanylf flmylinkde
     4801 tehtgqesyv wkmyqercwd ffpagdcfrk qyedqlg
//
LOCUS       XP_047288888            4831 aa            linear   PRI 05-AUG-2025
DEFINITION  ryanodine receptor 3 isoform X12 [Homo sapiens].
ACCESSION   XP_047288888
VERSION     XP_047288888.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432932.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4831
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4831
                     /product="ryanodine receptor 3 isoform X12"
                     /calculated_mol_wt=547202
     Region          14..212
                     /region_name="Ins145_P3_rec"
                     /note="Inositol 1,4,5-trisphosphate/ryanodine receptor;
                     pfam08709"
                     /db_xref="CDD:462572"
     Region          216..405
                     /region_name="beta-trefoil_MIR_RyR3"
                     /note="MIR domain, beta-trefoil fold, found in ryanodine
                     receptor 3 (RyR3) and similar proteins; cd23292"
                     /db_xref="CDD:467763"
     Site            391
                     /site_type="other"
                     /note="putative homotetramer interface [polypeptide
                     binding]"
                     /db_xref="CDD:467763"
     Region          442..621
                     /region_name="RYDR_ITPR"
                     /note="RIH domain; pfam01365"
                     /db_xref="CDD:460175"
     Region          641..792
                     /region_name="SPRY1_RyR"
                     /note="SPRY domain 1 (SPRY1) of ryanodine receptor (RyR);
                     cd12877"
                     /db_xref="CDD:240457"
     Region          849..937
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          963..1052
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          1072..1204
                     /region_name="SPRY2_RyR"
                     /note="SPRY domain 2 (SPRY2) of ryanodine receptor (RyR);
                     cd12878"
                     /db_xref="CDD:240458"
     Region          1324..1462
                     /region_name="SPRY3_RyR"
                     /note="SPRY domain 3 (SPRY3) of ryanodine receptor (RyR);
                     cd12879"
                     /db_xref="CDD:293937"
     Region          2023..2233
                     /region_name="RYDR_ITPR"
                     /note="RIH domain; pfam01365"
                     /db_xref="CDD:460175"
     Region          2598..2687
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          2716..2795
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          3717..3834
                     /region_name="RIH_assoc"
                     /note="RyR and IP3R Homology associated; pfam08454"
                     /db_xref="CDD:462482"
     Region          3918..3973
                     /region_name="EF-hand_7"
                     /note="EF-hand domain pair; pfam13499"
                     /db_xref="CDD:463900"
     Region          4224..4465
                     /region_name="RR_TM4-6"
                     /note="Ryanodine Receptor TM 4-6; pfam06459"
                     /db_xref="CDD:461918"
     Region          <4582..4742
                     /region_name="Ion_trans"
                     /note="Ion transport protein; pfam00520"
                     /db_xref="CDD:459842"
     CDS             1..4831
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /coded_by="XM_047432932.1:80..14575"
                     /db_xref="GeneID:6263"
                     /db_xref="HGNC:HGNC:10485"
                     /db_xref="MIM:180903"
ORIGIN      
        1 maeggegged eiqflrtede vvlqciatih keqrkfclaa eglgnrlcfl eptseakyip
       61 pdlcvcnfvl eqslsvralq emlantgeng gegaaqgggh rtllyghavl lrhsfsgmyl
      121 tclttsrsqt dklafdvglr ehatgeacww tihpaskqrs egekvrigdd lilvsvsser
      181 ylhlsvsngn iqvdasfmqt lwnvhptcsg ssieegyllg ghvvrlfhgh decltipstd
      241 qndsqhrrif yeaggagtra rslwrveplr iswsgsnirw gqafrlrhlt tghylalted
      301 qglilqdrak sdtkstafsf raskelkekl dsshkrdieg mgvpeikygd svcfvqhias
      361 glwvtykaqd aktsrlgplk rkvilhqegh mddgltlqrc qreesqaari irnttalfsq
      421 fvsgnnrtaa pitlpieevl qtlqdliayf qppeeemrhe dkqnklrslk nrqnlfkeeg
      481 mlalvlncid rlnvynsvah fagiareesg mawkeilnll ykllaalirg nrnncaqfsn
      541 nldwliskld rlesssgile vlhciltesp ealnliaegh iksiislldk hgrnhkvldi
      601 lcslclcngv avranqnlic dnllprrnll lqtrlindvt sirpniflgv aegsaqykkw
      661 yfeliidqvd pfltaepthl rvgwasssgy apypgggegw ggngvgddly sygfdglhlw
      721 sgripravas inqhllrsdd vvsccldlgv psisfringq pvqgmfenfn tdglffpvms
      781 fsagvkvrfl mggrhgefkf lppsgyapcy eallpkekmr lepvkeykrd adgirdllgt
      841 tqflsqasfi pcpvdtsqvi lpphlekird rlaenihelw gmnkielgwt fgkirddnkr
      901 qhpclvefsk lpeteknynl qmstetlktl lalgchiahv npaaeedlkk vklpknymms
      961 ngykpapldl sdvkllppqe ilvdklaena hnvwakdrik qgwtygiqqd lknkrnprlv
     1021 pyalldertk ksnrdslrea vrtfvgygyn iepsdqelad savekvsidk irffrversy
     1081 avrsgkwyfe fevvtggdmr vgwarpgcrp dvelgaddqa fvfegnrgqr whqgsgyfgr
     1141 twqpgdvvgc minlddasmi ftlngellit nkgselafad yeiengfvpi cclglsqigr
     1201 mnlgtdastf kfytmcglqe gfepfavnmn rdvamwfskr lptfvnvpkd hphievmrid
     1261 gtmdsppclk vthktfgtqn snadmiycrl smpvechssf shspcldsea fqkrkqmqei
     1321 lshtttqcyy airifagqdp scvwvgwvtp dyhlysekfd lnknctvtvt lgdergrvhe
     1381 svkrsncymv wggdivassq rsnrsnvdle igclvdlamg mlsfsangke lgtcyqvepn
     1441 tkvfpavflq ptstslfqfe lgklknampl saaifrseek npvpqcpprl dvqtiqpvlw
     1501 srmpnsflkv etervserhg wvvqcleplq mmalhipeen rcvdilelce qedlmrfhyh
     1561 tlrlysavca lgnsrvayal cshvdlsqlf yaidnkylpg llrsgfydll isihlasake
     1621 rklmmkneyi ipitsttrni rlfpdeskrh glpgvglrtc lkpgfrfstp cfvvtgedhq
     1681 kqspeiples lrtkalsmlt eavqcsgahi rdpvggsvef qfvpvlklig tllvmgvfdd
     1741 ddvrqillli dpsvfgehsa gteegaekee vtqveekave agekagkeap vkgllqtrlp
     1801 esvklqmcel lsylcdcelq hrveaivafg diyvsklqan qkfrynelmq alnmsaalta
     1861 rktkefrspp qeqinmllnf qlgencpcpe eireelydfh edlllhcgvp leeeeeeeed
     1921 tswtgklcal vykikgppkp ekeqpteeee rcpttlkeli sqtmicwaqe dqiqdselvr
     1981 mmfnllrrqy dsigellqal rktytishts vsdtinllaa lgqirsllsv rmgkeeellm
     2041 inglgdimnn kvfyqhpnlm rvlgmhetvm evmvnvlgte ksqiafpkmv asccrflcyf
     2101 crisrqnqka mfehlsylle nssvglasps mrgstpldva assvmdnnel alsleepdle
     2161 kvvtylagcg lqscpmllak gypdvgwnpi egerylsflr favfvnsesv eenasvvvkl
     2221 lirrpecfgp alrgeggngl laamqgaiki senpaldlps qgykrevstg ddeeeeeivh
     2281 mgnaimsfys alidllgrca pemhliqtgk geairirsil rslvptedlv giisiplklp
     2341 slnkdgsvse pdmaanfcpd hkapmvlfld rvygikdqtf llhllevgfl pdlrasasld
     2401 tvslstteaa lalnryicsa vlplltrcap lfagtehcts lidstlqtiy rlskgrsltk
     2461 aqrdtieecl laicnhlrps mlqqllrrlv fdvpqlneyc kmplklltnh yeqcwkyycl
     2521 psgwgsygla veeelhltek lfwgifdsls hkkydpdlfr malpclsaia galppdyldt
     2581 ritatlekqi svdadgnfdp kpintmnfsl pekleyivtk yaehshdkwa cdksqsgwky
     2641 gisldenvkt hplirpfktl tekekeiyrw pareslktml avgwtvertk egealvqqre
     2701 neklrsvsqa nqgnsyspap ldlsnvvlsr elqgmvevva enyhniwakk kkleleskgg
     2761 gshpllvpyd tltakekfkd rekaqdlfkf lqvngiivsr gmkdmeldas smekrfaykf
     2821 lkkilkyvds aqefiahlea ivssgkteks prdqeikffa kvllplvdqy ftshclyfls
     2881 splkplsssg yashkekemv aglfcklaal vrhrislfgs dsttmvsclh ilaqtldtrt
     2941 vmksgselvk aglraffena aedlektsen lklgkfthsr tqikgvsqni nyttvallpi
     3001 ltsifehvtq hqfgmdlllg dvqiscyhil cslyslgtgk niyverqrpa lgeclaslaa
     3061 aipvaflept lnrynplsvf ntktprersi lgmpdtvedm cpdipqlegl mkeindlaes
     3121 garytemphv ievilpmlcn ylsywwergp enlppstgpc ctkvtsehls lilgnilkii
     3181 nnnlgideas wmkriavyaq piiskarpdl lrshfiptle klkkkavktv qeeeqlkadg
     3241 kgdtqeaell ildefavlcr dlyafypmli ryvdnnrsnw lkspdadsdq lfrmvaevfi
     3301 lwckshnfkr eeqnfviqne innlafltgd skskmsksgg qdqerkktkr rgdlysiqts
     3361 livaalkkml piglnmctpg dqelislaks ryshrdtdee vrehlrnnlh lqeksddpav
     3421 kwqlnlykdv lkseepfnpe ktvervqris aavfhleqve qplrskkavw hkllskqrkr
     3481 avvacfrmap lynlprhkin nfflstfqqv wlekvnektq ydrlipilmk spkveeeeee
     3541 etekqpdplh qiilyfsrna lterskledd plytsyssmm akscqsgede eededkektf
     3601 eekemekqkt lyqqarlher gaaemvlqmi saskgemspm vvetlklgia ilnggnagvq
     3661 qkmldylkek kdagffqsls glmqscsvld lnaferqnka eglgmvteeg trekvlqnde
     3721 ftrdlfrflq llceghnsdf qnflrtqmgn tttvnviist vdyllrlqes isdfywyysg
     3781 kdiidesgqh nfskalavtk qifnslteyi qgpcignqqs lahsrlwdav vgflhvfanm
     3841 qmklsqdssq iellkelldl lqdmvvmlls llegnvvngt igkqmvdtlv esstnvemil
     3901 kffdmflklk dltssdtfke ydpdgkgiis kkefqkameg qkqytqseid fllscaeade
     3961 ndmfnyvdfv drfhepakdi gfnvavlltn lsehmpndsr lkclldpaes vlnyfepylg
     4021 rieimggakk iervyfeise ssrtqwekpq vkeskrqfif dvvneggeqe kmelfvnfce
     4081 dtifemqlas qisesdsadr peeeeededs syvleiagee eedgslepas afamacasvk
     4141 rnvtdflkra tlknlrkqyr nvkkmtakel vkvlfsffwm lfvglfqllf tilggifqil
     4201 wstvfggglv egaknirvtk ilgdmpdptq fgihddtmea eraevmepgi ttelvhfikg
     4261 ekgdtdimsd lfglhpkkeg slkhgpevgl gdlseiigkd epptlestvq kkrkaqaaem
     4321 kaaneaegkv esekadmedg ekedkdkeee qaeylwtevt kkkkrrcgqk vekpeaftan
     4381 ffkgleiyqt kllvteeple eetedvanlw nsfndeeeee amvffvlqes tgymaptlra
     4441 laiihtiisl vcvvgyyclk vplvvfkrek eiarklefdg lyiteqpsed dikgqwdrlv
     4501 intpsfpnny wdkfvkrkvi nkygdlygae riaellgldk naldfspvee tkaeaaslvs
     4561 wlssidmkyh iwklgvvftd nsflylawyt tmsvlghynn fffaahlldi amgfktlrti
     4621 lssvthngkq lvltvgllav vvylytvvaf nffrkfynks edddepdmkc ddmmtcylfh
     4681 myvgvraggg igdeiedpag dpyemyrivf ditffffviv illaiiqgli idafgelrdq
     4741 qeqvredmet kcficgignd yfdttphgfe thtlqehnla nylfflmyli nkdetehtgq
     4801 esyvwkmyqe rcwdffpagd cfrkqyedql g
//
LOCUS       XP_016877965            4830 aa            linear   PRI 05-AUG-2025
DEFINITION  ryanodine receptor 3 isoform X13 [Homo sapiens].
ACCESSION   XP_016877965
VERSION     XP_016877965.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022476.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4830
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4830
                     /product="ryanodine receptor 3 isoform X13"
                     /calculated_mol_wt=547601
     Region          14..176
                     /region_name="Ins145_P3_rec"
                     /note="Inositol 1,4,5-trisphosphate/ryanodine receptor;
                     pfam08709"
                     /db_xref="CDD:462572"
     Region          180..369
                     /region_name="beta-trefoil_MIR_RyR3"
                     /note="MIR domain, beta-trefoil fold, found in ryanodine
                     receptor 3 (RyR3) and similar proteins; cd23292"
                     /db_xref="CDD:467763"
     Site            355
                     /site_type="other"
                     /note="putative homotetramer interface [polypeptide
                     binding]"
                     /db_xref="CDD:467763"
     Region          406..585
                     /region_name="RYDR_ITPR"
                     /note="RIH domain; pfam01365"
                     /db_xref="CDD:460175"
     Region          605..756
                     /region_name="SPRY1_RyR"
                     /note="SPRY domain 1 (SPRY1) of ryanodine receptor (RyR);
                     cd12877"
                     /db_xref="CDD:240457"
     Region          813..901
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          927..1016
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          1036..1168
                     /region_name="SPRY2_RyR"
                     /note="SPRY domain 2 (SPRY2) of ryanodine receptor (RyR);
                     cd12878"
                     /db_xref="CDD:240458"
     Region          1288..1426
                     /region_name="SPRY3_RyR"
                     /note="SPRY domain 3 (SPRY3) of ryanodine receptor (RyR);
                     cd12879"
                     /db_xref="CDD:293937"
     Region          1987..2197
                     /region_name="RYDR_ITPR"
                     /note="RIH domain; pfam01365"
                     /db_xref="CDD:460175"
     Region          2562..2651
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          2680..2759
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          3687..3804
                     /region_name="RIH_assoc"
                     /note="RyR and IP3R Homology associated; pfam08454"
                     /db_xref="CDD:462482"
     Region          3888..3943
                     /region_name="EF-hand_7"
                     /note="EF-hand domain pair; pfam13499"
                     /db_xref="CDD:463900"
     Region          4194..4464
                     /region_name="RR_TM4-6"
                     /note="Ryanodine Receptor TM 4-6; pfam06459"
                     /db_xref="CDD:461918"
     Region          <4581..4741
                     /region_name="Ion_trans"
                     /note="Ion transport protein; pfam00520"
                     /db_xref="CDD:459842"
     CDS             1..4830
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /coded_by="XM_017022476.2:80..14572"
                     /db_xref="GeneID:6263"
                     /db_xref="HGNC:HGNC:10485"
                     /db_xref="MIM:180903"
ORIGIN      
        1 maeggegged eiqflrtede vvlqciatih keqrkfclaa eglgnrlcfl eptseakaaq
       61 ggghrtllyg havllrhsfs gmyltcltts rsqtdklafd vglrehatge acwwtihpas
      121 kqrsegekvr igddlilvsv sserylhlsv sngniqvdas fmqtlwnvhp tcsgssieeg
      181 yllgghvvrl fhghdeclti pstdqndsqh rrifyeagga gtrarslwrv eplriswsgs
      241 nirwgqafrl rhlttghyla ltedqglilq draksdtkst afsfraskel kekldsshkr
      301 diegmgvpei kygdsvcfvq hiasglwvty kaqdaktsrl gplkrkvilh qeghmddglt
      361 lqrcqreesq aariirntta lfsqfvsgnn rtaapitlpi eevlqtlqdl iayfqppeee
      421 mrhedkqnkl rslknrqnlf keegmlalvl ncidrlnvyn svahfagiar eesgmawkei
      481 lnllykllaa lirgnrnnca qfsnnldwli skldrlesss gilevlhcil tespealnli
      541 aeghiksiis lldkhgrnhk vldilcslcl cngvavranq nlicdnllpr rnlllqtrli
      601 ndvtsirpni flgvaegsaq ykkwyfelii dqvdpfltae pthlrvgwas ssgyapypgg
      661 gegwggngvg ddlysygfdg lhlwsgripr avasinqhll rsddvvsccl dlgvpsisfr
      721 ingqpvqgmf enfntdglff pvmsfsagvk vrflmggrhg efkflppsgy apcyeallpk
      781 ekmrlepvke ykrdadgird llgttqflsq asfipcpvdt sqvilpphle kirdrlaeni
      841 helwgmnkie lgwtfgkird dnkrqhpclv efsklpetek nynlqmstet lktllalgch
      901 iahvnpaaee dlkkvklpkn ymmsngykpa pldlsdvkll ppqeilvdkl aenahnvwak
      961 drikqgwtyg iqqdlknkrn prlvpyalld ertkksnrds lreavrtfvg ygyniepsdq
     1021 eladsavekv sidkirffrv ersyavrsgk wyfefevvtg gdmrvgwarp gcrpdvelga
     1081 ddqafvfegn rgqrwhqgsg yfgrtwqpgd vvgcminldd asmiftlnge llitnkgsel
     1141 afadyeieng fvpicclgls qigrmnlgtd astfkfytmc glqegfepfa vnmnrdvamw
     1201 fskrlptfvn vpkdhphiev mridgtmdsp pclkvthktf gtqnsnadmi ycrlsmpvec
     1261 hssfshspcl dseafqkrkq mqeilshttt qcyyairifa gqdpscvwvg wvtpdyhlys
     1321 ekfdlnknct vtvtlgderg rvhesvkrsn cymvwggdiv assqrsnrsn vdleigclvd
     1381 lamgmlsfsa ngkelgtcyq vepntkvfpa vflqptstsl fqfelgklkn amplsaaifr
     1441 seeknpvpqc pprldvqtiq pvlwsrmpns flkvetervs erhgwvvqcl eplqmmalhi
     1501 peenrcvdil elceqedlmr fhyhtlrlys avcalgnsrv ayalcshvdl sqlfyaidnk
     1561 ylpgllrsgf ydllisihla sakerklmmk neyiipitst trnirlfpde skrhglpgvg
     1621 lrtclkpgfr fstpcfvvtg edhqkqspei pleslrtkal smlteavqcs gahirdpvgg
     1681 svefqfvpvl kligtllvmg vfddddvrqi lllidpsvfg ehsagteega ekeevtqvee
     1741 kaveagekag keapvkgllq trlpesvklq mcellsylcd celqhrveai vafgdiyvsk
     1801 lqanqkfryn elmqalnmsa altarktkef rsppqeqinm llnfqlgenc pcpeeireel
     1861 ydfhedlllh cgvpleeeee eeedtswtgk lcalvykikg ppkpekeqpt eeeercpttl
     1921 kelisqtmic waqedqiqds elvrmmfnll rrqydsigel lqalrktyti shtsvsdtin
     1981 llaalgqirs llsvrmgkee ellminglgd imnnkvfyqh pnlmrvlgmh etvmevmvnv
     2041 lgteksqiaf pkmvasccrf lcyfcrisrq nqkamfehls yllenssvgl aspsmrgstp
     2101 ldvaassvmd nnelalslee pdlekvvtyl agcglqscpm llakgypdvg wnpiegeryl
     2161 sflrfavfvn sesveenasv vvkllirrpe cfgpalrgeg gngllaamqg aikisenpal
     2221 dlpsqgykre vstgddeeee eivhmgnaim sfysalidll grcapemhli qtgkgeairi
     2281 rsilrslvpt edlvgiisip lklpslnkdg svsepdmaan fcpdhkapmv lfldrvygik
     2341 dqtfllhlle vgflpdlras asldtvslst teaalalnry icsavlpllt rcaplfagte
     2401 hctslidstl qtiyrlskgr sltkaqrdti eecllaicnh lrpsmlqqll rrlvfdvpql
     2461 neyckmplkl ltnhyeqcwk yyclpsgwgs yglaveeelh lteklfwgif dslshkkydp
     2521 dlfrmalpcl saiagalppd yldtritatl ekqisvdadg nfdpkpintm nfslpekley
     2581 ivtkyaehsh dkwacdksqs gwkygislde nvkthplirp fktltekeke iyrwparesl
     2641 ktmlavgwtv ertkegealv qqreneklrs vsqanqgnsy spapldlsnv vlsrelqgmv
     2701 evvaenyhni wakkkklele skgggshpll vpydtltake kfkdrekaqd lfkflqvngi
     2761 ivsrgmkdme ldassmekrf aykflkkilk yvdsaqefia hleaivssgk teksprdqei
     2821 kffakvllpl vdqyftshcl yflssplkpl sssgyashke kemvaglfck laalvrhris
     2881 lfgsdsttmv sclhilaqtl dtrtvmksgs elvkaglraf fenaaedlek tsenlklgkf
     2941 thsrtqikgv sqninyttva llpiltsife hvtqhqfgmd lllgdvqisc yhilcslysl
     3001 gtgkniyver qrpalgecla slaaaipvaf leptlnrynp lsvfntktpr ersilgmpdt
     3061 vedmcpdipq leglmkeind laesgaryte mphvievilp mlcnylsyww ergpenlpps
     3121 tgpcctkvts ehlslilgni lkiinnnlgi deaswmkria vyaqpiiska rpdllrshfi
     3181 ptleklkkka vktvqeeeql kadgkgdtqe aellildefa vlcrdlyafy pmliryvdnn
     3241 rsnwlkspda dsdqlfrmva evfilwcksh nfkreeqnfv iqneinnlaf ltgdskskms
     3301 ksggqdqerk ktkrrgdlys iqtslivaal kkmlpiglnm ctpgdqelis laksryshrd
     3361 tdeevrehlr nnlhlqeksd dpavkwqlnl ykdvlkseep fnpektverv qrisaavfhl
     3421 eqveqplrsk kavwhkllsk qrkravvacf rmaplynlpr hkinnfflst fqqvwlekvn
     3481 ektqydrlip ilmkspkvee eeeeetekqp dplhqiilyf srnaltersk leddplytsy
     3541 ssmmakscqs gedeeededk ektfeekeme kqktlyqqar lhergaaemv lqmisaskge
     3601 mspmvvetlk lgiailnggn agvqqkmldy lkekkdagff qslsglmqsc svldlnafer
     3661 qnkaeglgmv teegtlivre rgekvlqnde ftrdlfrflq llceghnsdf qnflrtqmgn
     3721 tttvnviist vdyllrlqes isdfywyysg kdiidesgqh nfskalavtk qifnslteyi
     3781 qgpcignqqs lahsrlwdav vgflhvfanm qmklsqdssq iellkelldl lqdmvvmlls
     3841 llegnvvngt igkqmvdtlv esstnvemil kffdmflklk dltssdtfke ydpdgkgiis
     3901 kkefqkameg qkqytqseid fllscaeade ndmfnyvdfv drfhepakdi gfnvavlltn
     3961 lsehmpndsr lkclldpaes vlnyfepylg rieimggakk iervyfeise ssrtqwekpq
     4021 vkeskrqfif dvvneggeqe kmelfvnfce dtifemqlas qisesdsadr peeeeededs
     4081 syvleiagee eedgslepas afamacasvk rnvtdflkra tlknlrkqyr nvkkmtakel
     4141 vkvlfsffwm lfvglfqllf tilggifqil wstvfggglv egaknirvtk ilgdmpdptq
     4201 fgihddtmea eraevmepgi ttelvhfikg ekgdtdimsd lfglhpkkeg slkhgpevgl
     4261 gdlseiigkd epptlestvq kkrkaqaaem kaaneaegkv esekadmedg ekedkdkeee
     4321 qaeylwtevt kkkkrrcgqk vekpeaftan ffkgleiyqt kllhylarnf ynlrflalfv
     4381 afainfillf ykvteeplee etedvanlwn sfndeeeeea mvffvlqest gymaptlral
     4441 aiihtiislv cvvgyyclkv plvvfkreke iarklefdgl yiteqpsedd ikgqwdrlvi
     4501 ntpsfpnnyw dkfvkrkvin kygdlygaer iaellgldkn aldfspveet kaeaaslvsw
     4561 lssidmkyhi wklgvvftdn sflylawytt msvlghynnf ffaahlldia mgfktlrtil
     4621 ssvthngkql vltvgllavv vylytvvafn ffrkfynkse dddepdmkcd dmmtcylfhm
     4681 yvgvragggi gdeiedpagd pyemyrivfd itffffvivi llaiiqglii dafgelrdqq
     4741 eqvredmetk cficgigndy fdttphgfet htlqehnlan ylfflmylin kdetehtgqe
     4801 syvwkmyqer cwdffpagdc frkqyedqlg
//
LOCUS       XP_047288889            4402 aa            linear   PRI 05-AUG-2025
DEFINITION  ryanodine receptor 3 isoform X14 [Homo sapiens].
ACCESSION   XP_047288889
VERSION     XP_047288889.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432933.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4402
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4402
                     /product="ryanodine receptor 3 isoform X14"
                     /calculated_mol_wt=497326
     Region          14..212
                     /region_name="Ins145_P3_rec"
                     /note="Inositol 1,4,5-trisphosphate/ryanodine receptor;
                     pfam08709"
                     /db_xref="CDD:462572"
     Region          216..405
                     /region_name="beta-trefoil_MIR_RyR3"
                     /note="MIR domain, beta-trefoil fold, found in ryanodine
                     receptor 3 (RyR3) and similar proteins; cd23292"
                     /db_xref="CDD:467763"
     Site            391
                     /site_type="other"
                     /note="putative homotetramer interface [polypeptide
                     binding]"
                     /db_xref="CDD:467763"
     Region          442..621
                     /region_name="RYDR_ITPR"
                     /note="RIH domain; pfam01365"
                     /db_xref="CDD:460175"
     Region          641..792
                     /region_name="SPRY1_RyR"
                     /note="SPRY domain 1 (SPRY1) of ryanodine receptor (RyR);
                     cd12877"
                     /db_xref="CDD:240457"
     Region          849..937
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          963..1052
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          1072..1204
                     /region_name="SPRY2_RyR"
                     /note="SPRY domain 2 (SPRY2) of ryanodine receptor (RyR);
                     cd12878"
                     /db_xref="CDD:240458"
     Region          1324..1462
                     /region_name="SPRY3_RyR"
                     /note="SPRY domain 3 (SPRY3) of ryanodine receptor (RyR);
                     cd12879"
                     /db_xref="CDD:293937"
     Region          2023..2233
                     /region_name="RYDR_ITPR"
                     /note="RIH domain; pfam01365"
                     /db_xref="CDD:460175"
     Region          2598..2687
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          2716..2795
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          3723..3840
                     /region_name="RIH_assoc"
                     /note="RyR and IP3R Homology associated; pfam08454"
                     /db_xref="CDD:462482"
     Region          3924..3979
                     /region_name="EF-hand_7"
                     /note="EF-hand domain pair; pfam13499"
                     /db_xref="CDD:463900"
     Region          4230..>4399
                     /region_name="RR_TM4-6"
                     /note="Ryanodine Receptor TM 4-6; pfam06459"
                     /db_xref="CDD:461918"
     CDS             1..4402
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /coded_by="XM_047432933.1:80..13288"
                     /db_xref="GeneID:6263"
                     /db_xref="HGNC:HGNC:10485"
                     /db_xref="MIM:180903"
ORIGIN      
        1 maeggegged eiqflrtede vvlqciatih keqrkfclaa eglgnrlcfl eptseakyip
       61 pdlcvcnfvl eqslsvralq emlantgeng gegaaqgggh rtllyghavl lrhsfsgmyl
      121 tclttsrsqt dklafdvglr ehatgeacww tihpaskqrs egekvrigdd lilvsvsser
      181 ylhlsvsngn iqvdasfmqt lwnvhptcsg ssieegyllg ghvvrlfhgh decltipstd
      241 qndsqhrrif yeaggagtra rslwrveplr iswsgsnirw gqafrlrhlt tghylalted
      301 qglilqdrak sdtkstafsf raskelkekl dsshkrdieg mgvpeikygd svcfvqhias
      361 glwvtykaqd aktsrlgplk rkvilhqegh mddgltlqrc qreesqaari irnttalfsq
      421 fvsgnnrtaa pitlpieevl qtlqdliayf qppeeemrhe dkqnklrslk nrqnlfkeeg
      481 mlalvlncid rlnvynsvah fagiareesg mawkeilnll ykllaalirg nrnncaqfsn
      541 nldwliskld rlesssgile vlhciltesp ealnliaegh iksiislldk hgrnhkvldi
      601 lcslclcngv avranqnlic dnllprrnll lqtrlindvt sirpniflgv aegsaqykkw
      661 yfeliidqvd pfltaepthl rvgwasssgy apypgggegw ggngvgddly sygfdglhlw
      721 sgripravas inqhllrsdd vvsccldlgv psisfringq pvqgmfenfn tdglffpvms
      781 fsagvkvrfl mggrhgefkf lppsgyapcy eallpkekmr lepvkeykrd adgirdllgt
      841 tqflsqasfi pcpvdtsqvi lpphlekird rlaenihelw gmnkielgwt fgkirddnkr
      901 qhpclvefsk lpeteknynl qmstetlktl lalgchiahv npaaeedlkk vklpknymms
      961 ngykpapldl sdvkllppqe ilvdklaena hnvwakdrik qgwtygiqqd lknkrnprlv
     1021 pyalldertk ksnrdslrea vrtfvgygyn iepsdqelad savekvsidk irffrversy
     1081 avrsgkwyfe fevvtggdmr vgwarpgcrp dvelgaddqa fvfegnrgqr whqgsgyfgr
     1141 twqpgdvvgc minlddasmi ftlngellit nkgselafad yeiengfvpi cclglsqigr
     1201 mnlgtdastf kfytmcglqe gfepfavnmn rdvamwfskr lptfvnvpkd hphievmrid
     1261 gtmdsppclk vthktfgtqn snadmiycrl smpvechssf shspcldsea fqkrkqmqei
     1321 lshtttqcyy airifagqdp scvwvgwvtp dyhlysekfd lnknctvtvt lgdergrvhe
     1381 svkrsncymv wggdivassq rsnrsnvdle igclvdlamg mlsfsangke lgtcyqvepn
     1441 tkvfpavflq ptstslfqfe lgklknampl saaifrseek npvpqcpprl dvqtiqpvlw
     1501 srmpnsflkv etervserhg wvvqcleplq mmalhipeen rcvdilelce qedlmrfhyh
     1561 tlrlysavca lgnsrvayal cshvdlsqlf yaidnkylpg llrsgfydll isihlasake
     1621 rklmmkneyi ipitsttrni rlfpdeskrh glpgvglrtc lkpgfrfstp cfvvtgedhq
     1681 kqspeiples lrtkalsmlt eavqcsgahi rdpvggsvef qfvpvlklig tllvmgvfdd
     1741 ddvrqillli dpsvfgehsa gteegaekee vtqveekave agekagkeap vkgllqtrlp
     1801 esvklqmcel lsylcdcelq hrveaivafg diyvsklqan qkfrynelmq alnmsaalta
     1861 rktkefrspp qeqinmllnf qlgencpcpe eireelydfh edlllhcgvp leeeeeeeed
     1921 tswtgklcal vykikgppkp ekeqpteeee rcpttlkeli sqtmicwaqe dqiqdselvr
     1981 mmfnllrrqy dsigellqal rktytishts vsdtinllaa lgqirsllsv rmgkeeellm
     2041 inglgdimnn kvfyqhpnlm rvlgmhetvm evmvnvlgte ksqiafpkmv asccrflcyf
     2101 crisrqnqka mfehlsylle nssvglasps mrgstpldva assvmdnnel alsleepdle
     2161 kvvtylagcg lqscpmllak gypdvgwnpi egerylsflr favfvnsesv eenasvvvkl
     2221 lirrpecfgp alrgeggngl laamqgaiki senpaldlps qgykrevstg ddeeeeeivh
     2281 mgnaimsfys alidllgrca pemhliqtgk geairirsil rslvptedlv giisiplklp
     2341 slnkdgsvse pdmaanfcpd hkapmvlfld rvygikdqtf llhllevgfl pdlrasasld
     2401 tvslstteaa lalnryicsa vlplltrcap lfagtehcts lidstlqtiy rlskgrsltk
     2461 aqrdtieecl laicnhlrps mlqqllrrlv fdvpqlneyc kmplklltnh yeqcwkyycl
     2521 psgwgsygla veeelhltek lfwgifdsls hkkydpdlfr malpclsaia galppdyldt
     2581 ritatlekqi svdadgnfdp kpintmnfsl pekleyivtk yaehshdkwa cdksqsgwky
     2641 gisldenvkt hplirpfktl tekekeiyrw pareslktml avgwtvertk egealvqqre
     2701 neklrsvsqa nqgnsyspap ldlsnvvlsr elqgmvevva enyhniwakk kkleleskgg
     2761 gshpllvpyd tltakekfkd rekaqdlfkf lqvngiivsr gmkdmeldas smekrfaykf
     2821 lkkilkyvds aqefiahlea ivssgkteks prdqeikffa kvllplvdqy ftshclyfls
     2881 splkplsssg yashkekemv aglfcklaal vrhrislfgs dsttmvsclh ilaqtldtrt
     2941 vmksgselvk aglraffena aedlektsen lklgkfthsr tqikgvsqni nyttvallpi
     3001 ltsifehvtq hqfgmdlllg dvqiscyhil cslyslgtgk niyverqrpa lgeclaslaa
     3061 aipvaflept lnrynplsvf ntktprersi lgmpdtvedm cpdipqlegl mkeindlaes
     3121 garytemphv ievilpmlcn ylsywwergp enlppstgpc ctkvtsehls lilgnilkii
     3181 nnnlgideas wmkriavyaq piiskarpdl lrshfiptle klkkkavktv qeeeqlkadg
     3241 kgdtqeaell ildefavlcr dlyafypmli ryvdnnrsnw lkspdadsdq lfrmvaevfi
     3301 lwckshnfkr eeqnfviqne innlafltgd skskmsksgg qdqerkktkr rgdlysiqts
     3361 livaalkkml piglnmctpg dqelislaks ryshrdtdee vrehlrnnlh lqeksddpav
     3421 kwqlnlykdv lkseepfnpe ktvervqris aavfhleqve qplrskkavw hkllskqrkr
     3481 avvacfrmap lynlprhkin nfflstfqqv wlekvnektq ydrlipilmk spkveeeeee
     3541 etekqpdplh qiilyfsrna lterskledd plytsyssmm akscqsgede eededkektf
     3601 eekemekqkt lyqqarlher gaaemvlqmi saskgemspm vvetlklgia ilnggnagvq
     3661 qkmldylkek kdagffqsls glmqscsvld lnaferqnka eglgmvteeg tlivrergek
     3721 vlqndeftrd lfrflqllce ghnsdfqnfl rtqmgntttv nviistvdyl lrlqesisdf
     3781 ywyysgkdii desgqhnfsk alavtkqifn slteyiqgpc ignqqslahs rlwdavvgfl
     3841 hvfanmqmkl sqdssqiell kelldllqdm vvmllslleg nvvngtigkq mvdtlvesst
     3901 nvemilkffd mflklkdlts sdtfkeydpd gkgiiskkef qkamegqkqy tqseidflls
     3961 caeadendmf nyvdfvdrfh epakdigfnv avlltnlseh mpndsrlkcl ldpaesvlny
     4021 fepylgriei mggakkierv yfeisessrt qwekpqvkes krqfifdvvn eggeqekmel
     4081 fvnfcedtif emqlasqise sdsadrpeee eededssyvl eiageeeedg slepasafam
     4141 acasvkrnvt dflkratlkn lrkqyrnvkk mtakelvkvl fsffwmlfvg lfqllftilg
     4201 gifqilwstv fggglvegak nirvtkilgd mpdptqfgih ddtmeaerae vmepgittel
     4261 vhfikgekgd tdimsdlfgl hpkkegslkh gpevglgdls eiigkdeppt lestvqkkrk
     4321 aqaaemkaan eaegkvesek admedgeked kdkeeeqaey lwtevtkkkk rrcgqkvekp
     4381 eaftanffkg leiyqtkllp gh
//
LOCUS       XP_016877966            3855 aa            linear   PRI 05-AUG-2025
DEFINITION  ryanodine receptor 3 isoform X15 [Homo sapiens].
ACCESSION   XP_016877966
VERSION     XP_016877966.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022477.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..3855
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..3855
                     /product="ryanodine receptor 3 isoform X15"
                     /calculated_mol_wt=435342
     Region          14..212
                     /region_name="Ins145_P3_rec"
                     /note="Inositol 1,4,5-trisphosphate/ryanodine receptor;
                     pfam08709"
                     /db_xref="CDD:462572"
     Region          216..405
                     /region_name="beta-trefoil_MIR_RyR3"
                     /note="MIR domain, beta-trefoil fold, found in ryanodine
                     receptor 3 (RyR3) and similar proteins; cd23292"
                     /db_xref="CDD:467763"
     Site            391
                     /site_type="other"
                     /note="putative homotetramer interface [polypeptide
                     binding]"
                     /db_xref="CDD:467763"
     Region          442..621
                     /region_name="RYDR_ITPR"
                     /note="RIH domain; pfam01365"
                     /db_xref="CDD:460175"
     Region          641..792
                     /region_name="SPRY1_RyR"
                     /note="SPRY domain 1 (SPRY1) of ryanodine receptor (RyR);
                     cd12877"
                     /db_xref="CDD:240457"
     Region          849..937
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          963..1052
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          1072..1204
                     /region_name="SPRY2_RyR"
                     /note="SPRY domain 2 (SPRY2) of ryanodine receptor (RyR);
                     cd12878"
                     /db_xref="CDD:240458"
     Region          1324..1462
                     /region_name="SPRY3_RyR"
                     /note="SPRY domain 3 (SPRY3) of ryanodine receptor (RyR);
                     cd12879"
                     /db_xref="CDD:293937"
     Region          2023..2233
                     /region_name="RYDR_ITPR"
                     /note="RIH domain; pfam01365"
                     /db_xref="CDD:460175"
     Region          2598..2687
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          2716..2795
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          3723..3840
                     /region_name="RIH_assoc"
                     /note="RyR and IP3R Homology associated; pfam08454"
                     /db_xref="CDD:462482"
     CDS             1..3855
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /coded_by="XM_017022477.2:80..11647"
                     /db_xref="GeneID:6263"
                     /db_xref="HGNC:HGNC:10485"
                     /db_xref="MIM:180903"
ORIGIN      
        1 maeggegged eiqflrtede vvlqciatih keqrkfclaa eglgnrlcfl eptseakyip
       61 pdlcvcnfvl eqslsvralq emlantgeng gegaaqgggh rtllyghavl lrhsfsgmyl
      121 tclttsrsqt dklafdvglr ehatgeacww tihpaskqrs egekvrigdd lilvsvsser
      181 ylhlsvsngn iqvdasfmqt lwnvhptcsg ssieegyllg ghvvrlfhgh decltipstd
      241 qndsqhrrif yeaggagtra rslwrveplr iswsgsnirw gqafrlrhlt tghylalted
      301 qglilqdrak sdtkstafsf raskelkekl dsshkrdieg mgvpeikygd svcfvqhias
      361 glwvtykaqd aktsrlgplk rkvilhqegh mddgltlqrc qreesqaari irnttalfsq
      421 fvsgnnrtaa pitlpieevl qtlqdliayf qppeeemrhe dkqnklrslk nrqnlfkeeg
      481 mlalvlncid rlnvynsvah fagiareesg mawkeilnll ykllaalirg nrnncaqfsn
      541 nldwliskld rlesssgile vlhciltesp ealnliaegh iksiislldk hgrnhkvldi
      601 lcslclcngv avranqnlic dnllprrnll lqtrlindvt sirpniflgv aegsaqykkw
      661 yfeliidqvd pfltaepthl rvgwasssgy apypgggegw ggngvgddly sygfdglhlw
      721 sgripravas inqhllrsdd vvsccldlgv psisfringq pvqgmfenfn tdglffpvms
      781 fsagvkvrfl mggrhgefkf lppsgyapcy eallpkekmr lepvkeykrd adgirdllgt
      841 tqflsqasfi pcpvdtsqvi lpphlekird rlaenihelw gmnkielgwt fgkirddnkr
      901 qhpclvefsk lpeteknynl qmstetlktl lalgchiahv npaaeedlkk vklpknymms
      961 ngykpapldl sdvkllppqe ilvdklaena hnvwakdrik qgwtygiqqd lknkrnprlv
     1021 pyalldertk ksnrdslrea vrtfvgygyn iepsdqelad savekvsidk irffrversy
     1081 avrsgkwyfe fevvtggdmr vgwarpgcrp dvelgaddqa fvfegnrgqr whqgsgyfgr
     1141 twqpgdvvgc minlddasmi ftlngellit nkgselafad yeiengfvpi cclglsqigr
     1201 mnlgtdastf kfytmcglqe gfepfavnmn rdvamwfskr lptfvnvpkd hphievmrid
     1261 gtmdsppclk vthktfgtqn snadmiycrl smpvechssf shspcldsea fqkrkqmqei
     1321 lshtttqcyy airifagqdp scvwvgwvtp dyhlysekfd lnknctvtvt lgdergrvhe
     1381 svkrsncymv wggdivassq rsnrsnvdle igclvdlamg mlsfsangke lgtcyqvepn
     1441 tkvfpavflq ptstslfqfe lgklknampl saaifrseek npvpqcpprl dvqtiqpvlw
     1501 srmpnsflkv etervserhg wvvqcleplq mmalhipeen rcvdilelce qedlmrfhyh
     1561 tlrlysavca lgnsrvayal cshvdlsqlf yaidnkylpg llrsgfydll isihlasake
     1621 rklmmkneyi ipitsttrni rlfpdeskrh glpgvglrtc lkpgfrfstp cfvvtgedhq
     1681 kqspeiples lrtkalsmlt eavqcsgahi rdpvggsvef qfvpvlklig tllvmgvfdd
     1741 ddvrqillli dpsvfgehsa gteegaekee vtqveekave agekagkeap vkgllqtrlp
     1801 esvklqmcel lsylcdcelq hrveaivafg diyvsklqan qkfrynelmq alnmsaalta
     1861 rktkefrspp qeqinmllnf qlgencpcpe eireelydfh edlllhcgvp leeeeeeeed
     1921 tswtgklcal vykikgppkp ekeqpteeee rcpttlkeli sqtmicwaqe dqiqdselvr
     1981 mmfnllrrqy dsigellqal rktytishts vsdtinllaa lgqirsllsv rmgkeeellm
     2041 inglgdimnn kvfyqhpnlm rvlgmhetvm evmvnvlgte ksqiafpkmv asccrflcyf
     2101 crisrqnqka mfehlsylle nssvglasps mrgstpldva assvmdnnel alsleepdle
     2161 kvvtylagcg lqscpmllak gypdvgwnpi egerylsflr favfvnsesv eenasvvvkl
     2221 lirrpecfgp alrgeggngl laamqgaiki senpaldlps qgykrevstg ddeeeeeivh
     2281 mgnaimsfys alidllgrca pemhliqtgk geairirsil rslvptedlv giisiplklp
     2341 slnkdgsvse pdmaanfcpd hkapmvlfld rvygikdqtf llhllevgfl pdlrasasld
     2401 tvslstteaa lalnryicsa vlplltrcap lfagtehcts lidstlqtiy rlskgrsltk
     2461 aqrdtieecl laicnhlrps mlqqllrrlv fdvpqlneyc kmplklltnh yeqcwkyycl
     2521 psgwgsygla veeelhltek lfwgifdsls hkkydpdlfr malpclsaia galppdyldt
     2581 ritatlekqi svdadgnfdp kpintmnfsl pekleyivtk yaehshdkwa cdksqsgwky
     2641 gisldenvkt hplirpfktl tekekeiyrw pareslktml avgwtvertk egealvqqre
     2701 neklrsvsqa nqgnsyspap ldlsnvvlsr elqgmvevva enyhniwakk kkleleskgg
     2761 gshpllvpyd tltakekfkd rekaqdlfkf lqvngiivsr gmkdmeldas smekrfaykf
     2821 lkkilkyvds aqefiahlea ivssgkteks prdqeikffa kvllplvdqy ftshclyfls
     2881 splkplsssg yashkekemv aglfcklaal vrhrislfgs dsttmvsclh ilaqtldtrt
     2941 vmksgselvk aglraffena aedlektsen lklgkfthsr tqikgvsqni nyttvallpi
     3001 ltsifehvtq hqfgmdlllg dvqiscyhil cslyslgtgk niyverqrpa lgeclaslaa
     3061 aipvaflept lnrynplsvf ntktprersi lgmpdtvedm cpdipqlegl mkeindlaes
     3121 garytemphv ievilpmlcn ylsywwergp enlppstgpc ctkvtsehls lilgnilkii
     3181 nnnlgideas wmkriavyaq piiskarpdl lrshfiptle klkkkavktv qeeeqlkadg
     3241 kgdtqeaell ildefavlcr dlyafypmli ryvdnnrsnw lkspdadsdq lfrmvaevfi
     3301 lwckshnfkr eeqnfviqne innlafltgd skskmsksgg qdqerkktkr rgdlysiqts
     3361 livaalkkml piglnmctpg dqelislaks ryshrdtdee vrehlrnnlh lqeksddpav
     3421 kwqlnlykdv lkseepfnpe ktvervqris aavfhleqve qplrskkavw hkllskqrkr
     3481 avvacfrmap lynlprhkin nfflstfqqv wlekvnektq ydrlipilmk spkveeeeee
     3541 etekqpdplh qiilyfsrna lterskledd plytsyssmm akscqsgede eededkektf
     3601 eekemekqkt lyqqarlher gaaemvlqmi saskgemspm vvetlklgia ilnggnagvq
     3661 qkmldylkek kdagffqsls glmqscsvld lnaferqnka eglgmvteeg tlivrergek
     3721 vlqndeftrd lfrflqllce ghnsdfqnfl rtqmgntttv nviistvdyl lrlqesisdf
     3781 ywyysgkdii desgqhnfsk alavtkqifn slteyiqgpc ignqqslahs rlwdavvgfl
     3841 hvfanmqmkl sqgmw
//
LOCUS       XP_024305784            4863 aa            linear   PRI 05-AUG-2025
DEFINITION  ryanodine receptor 3 isoform X16 [Homo sapiens].
ACCESSION   XP_024305784
VERSION     XP_024305784.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024450016.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4863
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4863
                     /product="ryanodine receptor 3 isoform X16"
                     /calculated_mol_wt=551141
     Region          14..212
                     /region_name="Ins145_P3_rec"
                     /note="Inositol 1,4,5-trisphosphate/ryanodine receptor;
                     pfam08709"
                     /db_xref="CDD:462572"
     Region          216..405
                     /region_name="beta-trefoil_MIR_RyR3"
                     /note="MIR domain, beta-trefoil fold, found in ryanodine
                     receptor 3 (RyR3) and similar proteins; cd23292"
                     /db_xref="CDD:467763"
     Site            391
                     /site_type="other"
                     /note="putative homotetramer interface [polypeptide
                     binding]"
                     /db_xref="CDD:467763"
     Region          442..621
                     /region_name="RYDR_ITPR"
                     /note="RIH domain; pfam01365"
                     /db_xref="CDD:460175"
     Region          641..792
                     /region_name="SPRY1_RyR"
                     /note="SPRY domain 1 (SPRY1) of ryanodine receptor (RyR);
                     cd12877"
                     /db_xref="CDD:240457"
     Region          849..937
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          963..1052
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          1072..1204
                     /region_name="SPRY2_RyR"
                     /note="SPRY domain 2 (SPRY2) of ryanodine receptor (RyR);
                     cd12878"
                     /db_xref="CDD:240458"
     Region          1318..1461
                     /region_name="SPRY3_RyR"
                     /note="SPRY domain 3 (SPRY3) of ryanodine receptor (RyR);
                     cd12879"
                     /db_xref="CDD:293937"
     Region          2022..2232
                     /region_name="RYDR_ITPR"
                     /note="RIH domain; pfam01365"
                     /db_xref="CDD:460175"
     Region          2596..2685
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          2714..2793
                     /region_name="RyR"
                     /note="RyR domain; pfam02026"
                     /db_xref="CDD:460419"
     Region          3720..3837
                     /region_name="RIH_assoc"
                     /note="RyR and IP3R Homology associated; pfam08454"
                     /db_xref="CDD:462482"
     Region          3921..3976
                     /region_name="EF-hand_7"
                     /note="EF-hand domain pair; pfam13499"
                     /db_xref="CDD:463900"
     Region          4227..4497
                     /region_name="RR_TM4-6"
                     /note="Ryanodine Receptor TM 4-6; pfam06459"
                     /db_xref="CDD:461918"
     Region          <4614..4774
                     /region_name="Ion_trans"
                     /note="Ion transport protein; pfam00520"
                     /db_xref="CDD:459842"
     CDS             1..4863
                     /gene="RYR3"
                     /gene_synonym="CMYO20; CMYP20; RYR-3"
                     /coded_by="XM_024450016.2:80..14671"
                     /db_xref="GeneID:6263"
                     /db_xref="HGNC:HGNC:10485"
                     /db_xref="MIM:180903"
ORIGIN      
        1 maeggegged eiqflrtede vvlqciatih keqrkfclaa eglgnrlcfl eptseakyip
       61 pdlcvcnfvl eqslsvralq emlantgeng gegaaqgggh rtllyghavl lrhsfsgmyl
      121 tclttsrsqt dklafdvglr ehatgeacww tihpaskqrs egekvrigdd lilvsvsser
      181 ylhlsvsngn iqvdasfmqt lwnvhptcsg ssieegyllg ghvvrlfhgh decltipstd
      241 qndsqhrrif yeaggagtra rslwrveplr iswsgsnirw gqafrlrhlt tghylalted
      301 qglilqdrak sdtkstafsf raskelkekl dsshkrdieg mgvpeikygd svcfvqhias
      361 glwvtykaqd aktsrlgplk rkvilhqegh mddgltlqrc qreesqaari irnttalfsq
      421 fvsgnnrtaa pitlpieevl qtlqdliayf qppeeemrhe dkqnklrslk nrqnlfkeeg
      481 mlalvlncid rlnvynsvah fagiareesg mawkeilnll ykllaalirg nrnncaqfsn
      541 nldwliskld rlesssgile vlhciltesp ealnliaegh iksiislldk hgrnhkvldi
      601 lcslclcngv avranqnlic dnllprrnll lqtrlindvt sirpniflgv aegsaqykkw
      661 yfeliidqvd pfltaepthl rvgwasssgy apypgggegw ggngvgddly sygfdglhlw
      721 sgripravas inqhllrsdd vvsccldlgv psisfringq pvqgmfenfn tdglffpvms
      781 fsagvkvrfl mggrhgefkf lppsgyapcy eallpkekmr lepvkeykrd adgirdllgt
      841 tqflsqasfi pcpvdtsqvi lpphlekird rlaenihelw gmnkielgwt fgkirddnkr
      901 qhpclvefsk lpeteknynl qmstetlktl lalgchiahv npaaeedlkk vklpknymms
      961 ngykpapldl sdvkllppqe ilvdklaena hnvwakdrik qgwtygiqqd lknkrnprlv
     1021 pyalldertk ksnrdslrea vrtfvgygyn iepsdqelad savekvsidk irffrversy
     1081 avrsgkwyfe fevvtggdmr vgwarpgcrp dvelgaddqa fvfegnrgqr whqgsgyfgr
     1141 twqpgdvvgc minlddasmi ftlngellit nkgselafad yeiengfvpi cclglsqigr
     1201 mnlgtdastf kfytmcglqe gfepfavnmn rdvamwfskr lptfvnvpkd hphievmrid
     1261 gtmdsppclk vthktfgtqn snadmiycrl smpvechssf shspcldsea fqkrkqmqei
     1321 lshtttcyya irifagqdps cvwvgwvtpd yhlysekfdl nknctvtvtl gdergrvhes
     1381 vkrsncymvw ggdivassqr snrsnvdlei gclvdlamgm lsfsangkel gtcyqvepnt
     1441 kvfpavflqp tstslfqfel gklknampls aaifrseekn pvpqcpprld vqtiqpvlws
     1501 rmpnsflkve tervserhgw vvqcleplqm malhipeenr cvdilelceq edlmrfhyht
     1561 lrlysavcal gnsrvayalc shvdlsqlfy aidnkylpgl lrsgfydlli sihlasaker
     1621 klmmkneyii pitsttrnir lfpdeskrhg lpgvglrtcl kpgfrfstpc fvvtgedhqk
     1681 qspeiplesl rtkalsmlte avqcsgahir dpvggsvefq fvpvlkligt llvmgvfddd
     1741 dvrqilllid psvfgehsag teegaekeev tqveekavea gekagkeapv kgllqtrlpe
     1801 svklqmcell sylcdcelqh rveaivafgd iyvsklqanq kfrynelmqa lnmsaaltar
     1861 ktkefrsppq eqinmllnfq lgencpcpee ireelydfhe dlllhcgvpl eeeeeeeedt
     1921 swtgklcalv ykikgppkpe keqpteeeer cpttlkelis qtmicwaqed qiqdselvrm
     1981 mfnllrrqyd sigellqalr ktytishtsv sdtinllaal gqirsllsvr mgkeeellmi
     2041 nglgdimnnk vfyqhpnlmr vlgmhetvme vmvnvlgtek sqiafpkmva sccrflcyfc
     2101 risrqnqkam fehlsyllen ssvglaspsm rgstpldvaa ssvmdnnela lsleepdlek
     2161 vvtylagcgl qscpmllakg ypdvgwnpie gerylsflrf avfvnsesve enasvvvkll
     2221 irrpecfgpa lrgeggngll aamqgaikis enpaldlpsq gykrevtgdd eeeeeivhmg
     2281 naimsfysal idllgrcape mhliqtgkge airirsilrs lvptedlvgi isiplklpsl
     2341 nkdgsvsepd maanfcpdhk apmvlfldrv ygikdqtfll hllevgflpd lrasasldtv
     2401 slstteaala lnryicsavl plltrcaplf agtehctsli dstlqtiyrl skgrsltkaq
     2461 rdtieeclla icnhlrpsml qqllrrlvfd vpqlneyckm plklltnhye qcwkyyclps
     2521 gwgsyglave eelhlteklf wgifdslshk kydpdlfrma lpclsaiaga lppdyldtri
     2581 tatlekqisv dadgnfdpkp intmnfslpe kleyivtkya ehshdkwacd ksqsgwkygi
     2641 sldenvkthp lirpfktlte kekeiyrwpa reslktmlav gwtvertkeg ealvqqrene
     2701 klrsvsqanq gnsyspapld lsnvvlsrel qgmvevvaen yhniwakkkk leleskgggs
     2761 hpllvpydtl takekfkdre kaqdlfkflq vngiivsrgm kdmeldassm ekrfaykflk
     2821 kilkyvdsaq efiahleaiv ssgktekspr dqeikffakv llplvdqyft shclyflssp
     2881 lkplsssgya shkekemvag lfcklaalvr hrislfgsds ttmvsclhil aqtldtrtvm
     2941 ksgselvkag lraffenaae dlektsenlk lgkfthsrtq ikgvsqniny ttvallpilt
     3001 sifehvtqhq fgmdlllgdv qiscyhilcs lyslgtgkni yverqrpalg eclaslaaai
     3061 pvafleptln rynplsvfnt ktprersilg mpdtvedmcp dipqleglmk eindlaesga
     3121 rytemphvie vilpmlcnyl sywwergpen lppstgpcct kvtsehlsli lgnilkiinn
     3181 nlgideaswm kriavyaqpi iskarpdllr shfiptlekl kkkavktvqe eeqlkadgkg
     3241 dtqeaellil defavlcrdl yafypmliry vdnnrsnwlk spdadsdqlf rmvaevfilw
     3301 ckshnfkree qnfviqnein nlafltgdsk skmsksggqd qerkktkrrg dlysiqtsli
     3361 vaalkkmlpi glnmctpgdq elislaksry shrdtdeevr ehlrnnlhlq eksddpavkw
     3421 qlnlykdvlk seepfnpekt vervqrisaa vfhleqveqp lrskkavwhk llskqrkrav
     3481 vacfrmaply nlprhrsinl flhgyqrfwi eteeysfeek lvqdlakspk veeeeeeete
     3541 kqpdplhqii lyfsrnalte rskleddply tsyssmmaks cqsgedeeed edkektfeek
     3601 emekqktlyq qarlhergaa emvlqmisas kgemspmvve tlklgiailn ggnagvqqkm
     3661 ldylkekkda gffqslsglm qscsvldlna ferqnkaegl gmvteegtli vrergekvlq
     3721 ndeftrdlfr flqllceghn sdfqnflrtq mgntttvnvi istvdyllrl qesisdfywy
     3781 ysgkdiides gqhnfskala vtkqifnslt eyiqgpcign qqslahsrlw davvgflhvf
     3841 anmqmklsqd ssqiellkel ldllqdmvvm llsllegnvv ngtigkqmvd tlvesstnve
     3901 milkffdmfl klkdltssdt fkeydpdgkg iiskkefqka megqkqytqs eidfllscae
     3961 adendmfnyv dfvdrfhepa kdigfnvavl ltnlsehmpn dsrlkclldp aesvlnyfep
     4021 ylgrieimgg akkiervyfe isessrtqwe kpqvkeskrq fifdvvnegg eqekmelfvn
     4081 fcedtifemq lasqisesds adrpeeeeed edssyvleia geeeedgsle pasafamaca
     4141 svkrnvtdfl kratlknlrk qyrnvkkmta kelvkvlfsf fwmlfvglfq llftilggif
     4201 qilwstvfgg glvegaknir vtkilgdmpd ptqfgihddt meaeraevme pgittelvhf
     4261 ikgekgdtdi msdlfglhpk kegslkhgpe vglgdlseii gkdepptles tvqkkrkaqa
     4321 aemkaaneae gkvesekadm edgekedkdk eeeqaeylwt evtkkkkrrc gqkvekpeaf
     4381 tanffkglei yqtkllhyla rnfynlrfla lfvafainfi llfykvteep leeetedvan
     4441 lwnsfndeee eeamvffvlq estgymaptl ralaiihtii slvcvvgyyc lkvplvvfkr
     4501 ekeiarklef dglyiteqps eddikgqwdr lvintpsfpn nywdkfvkrk vinkygdlyg
     4561 aeriaellgl dknaldfspv eetkaeaasl vswlssidmk yhiwklgvvf tdnsflylaw
     4621 yttmsvlghy nnfffaahll diamgfktlr tilssvthng kqlvltvgll avvvylytvv
     4681 afnffrkfyn ksedddepdm kcddmmtcyl fhmyvgvrag ggigdeiedp agdpyemyri
     4741 vfditffffv ivillaiiqg liidafgelr dqqeqvredm etkcficgig ndyfdttphg
     4801 fethtlqehn lanylfflmy linkdeteht gqesyvwkmy qercwdffpa gdcfrkqyed
     4861 qlg
//
LOCUS       XP_047288890             979 aa            linear   PRI 05-AUG-2025
DEFINITION  recQ-like DNA helicase BLM isoform X1 [Homo sapiens].
ACCESSION   XP_047288890
VERSION     XP_047288890.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432934.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..979
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..979
                     /product="recQ-like DNA helicase BLM isoform X1"
                     /calculated_mol_wt=109581
     Region          1..209
                     /region_name="BDHCT_assoc"
                     /note="BDHCT-box associated domain on Bloom syndrome
                     protein; pfam16204"
                     /db_xref="CDD:465065"
     Region          219..705
                     /region_name="recQ_fam"
                     /note="ATP-dependent DNA helicase, RecQ family; TIGR00614"
                     /db_xref="CDD:129701"
     Region          775..854
                     /region_name="HRDC"
                     /note="Helicase and RNase D C-terminal; smart00341"
                     /db_xref="CDD:128635"
     CDS             1..979
                     /gene="BLM"
                     /gene_synonym="BS; MGRISCE1; RECQ2; RECQL2; RECQL3"
                     /coded_by="XM_047432934.1:173..3112"
                     /db_xref="GeneID:641"
                     /db_xref="HGNC:HGNC:1058"
                     /db_xref="MIM:604610"
ORIGIN      
        1 megdscptgn smkelnfshl psnsvspgdc lltttlgktg fsatrknlfe rplfnthlqk
       61 sfvssnwaet prlgkkness yfpgnvltst avkdqnkhta sindleretq psydidnfdi
      121 ddfdddddwe dimhnlaask sstaayqpik egrpiksvse rlssaktdcl pvsstaqnin
      181 fsesiqnytd ksaqnlasrn lkherfqsls fphtkemmki fhkkfglhnf rtnqleaina
      241 allgedcfil mptgggkslc yqlpacvspg vtvvisplrs livdqvqklt sldipatylt
      301 gdktdseatn iylqlskkdp iikllyvtpe kicasnrlis tlenlyerkl larfvideah
      361 cvsqwghdfr qdykrmnmlr qkfpsvpvma ltatanprvq kdiltqlkil rpqvfsmsfn
      421 rhnlkyyvlp kkpkkvafdc lewirkhhpy dsgiiyclsr recdtmadtl qrdglaalay
      481 haglsdsard evqqkwinqd gcqvicatia fgmgidkpdv rfvihaslpk svegyyqesg
      541 ragrdgeish cllfytyhdv trlkrlimme kdgnhhtret hfnnlysmvh ycenitecrr
      601 iqllayfgen gfnpdfckkh pdvscdncck tkdyktrdvt ddvksivrfv qehsssqgmr
      661 nikhvgpsgr ftmnmlvdif lgsksakiqs gifgkgsays rhnaerlfkk lildkilded
      721 lyinandqai ayvmlgnkaq tvlngnlkvd fmetensssv kkqkalvakv sqreemvkkc
      781 lgeltevcks lgkvfgvhyf nifntvtlkk laeslssdpe vllqidgvte dklekygaev
      841 isvlqkysew tspaedsspg islsssrgpg rsaaeeldee ipvsshyfas ktrnerkrkk
      901 mpasqrskrr ktassgskak ggsatcrkis sktksssiig sssashtsqa tsgansklgi
      961 mappkpinrp flkpsyafs
//
LOCUS       XP_011520184             907 aa            linear   PRI 05-AUG-2025
DEFINITION  recQ-like DNA helicase BLM isoform X2 [Homo sapiens].
ACCESSION   XP_011520184
VERSION     XP_011520184.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521882.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..907
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..907
                     /product="recQ-like DNA helicase BLM isoform X2"
                     /calculated_mol_wt=101596
     Region          1..368
                     /region_name="BLM_N"
                     /note="N-terminal region of Bloom syndrome protein;
                     pfam16202"
                     /db_xref="CDD:465064"
     Region          372..412
                     /region_name="BDHCT"
                     /note="BDHCT (NUC031) domain; pfam08072"
                     /db_xref="CDD:462356"
     Region          425..647
                     /region_name="BDHCT_assoc"
                     /note="BDHCT-box associated domain on Bloom syndrome
                     protein; pfam16204"
                     /db_xref="CDD:465065"
     Region          651..852
                     /region_name="DEXHc_RecQ2_BLM"
                     /note="DEAH-box helicase domain of RecQ2; cd18016"
                     /db_xref="CDD:350774"
     Site            order(665,667,669,672,690..696)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:350774"
     Site            order(715..717,738..739,766,768..769,803,807..808)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:350774"
     CDS             1..907
                     /gene="BLM"
                     /gene_synonym="BS; MGRISCE1; RECQ2; RECQL2; RECQL3"
                     /coded_by="XM_011521882.4:100..2823"
                     /db_xref="GeneID:641"
                     /db_xref="HGNC:HGNC:1058"
                     /db_xref="MIM:604610"
ORIGIN      
        1 maavpqnnlq eqlerhsart lnnklslskp kfsgftfkkk tssdnnvsvt nvsvaktpvl
       61 rnkdvnvted fsfseplpnt tnqqrvkdff knapagqetq rggsksllpd flqtpkevvc
      121 ttqntptvkk srdtalkkle fssspdslst indwddmddf dtsetsksfv tppqshfvrv
      181 staqkskkgk rnffkaqlyt tntvktdlpp psseseqidl teeqkddsew lssdvicidd
      241 gpiaevhine daqesdslkt hlederdnse kkknleeael hstekvpcie fddddydtdf
      301 vppspeeiis assssskcls tlkdldtsdr kedvlstskd llskpekmsm qelnpetstd
      361 cdarqislqq qlihvmehic klidtipddk lklldcgnel lqqrnirrkl ltevdfnksd
      421 asllgslwry rpdsldgpme gdscptgnsm kelnfshlps nsvspgdcll tttlgktgfs
      481 atrknlferp lfnthlqksf vssnwaetpr lgkknessyf pgnvltstav kdqnkhtasi
      541 ndleretqps ydidnfdidd fdddddwedi mhnlaaskss taayqpikeg rpiksvserl
      601 ssaktdclpv sstaqninfs esiqnytdks aqnlasrnlk herfqslsfp htkemmkifh
      661 kkfglhnfrt nqleainaal lgedcfilmp tgggkslcyq lpacvspgvt vvisplrsli
      721 vdqvqkltsl dipatyltgd ktdseatniy lqlskkdpii kllyvtpeki casnrlistl
      781 enlyerklla rfvideahcv sqwghdfrqd ykrmnmlrqk fpsvpvmalt atanprvqkd
      841 iltqlkilrp qvivqpspis kftaflspqr etwyplaaap hllplvcarl lslsvvfkgh
      901 pccsigq
//
LOCUS       XP_006720695             763 aa            linear   PRI 05-AUG-2025
DEFINITION  recQ-like DNA helicase BLM isoform X3 [Homo sapiens].
ACCESSION   XP_006720695
VERSION     XP_006720695.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720632.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..763
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..763
                     /product="recQ-like DNA helicase BLM isoform X3"
                     /calculated_mol_wt=85507
     Region          3..489
                     /region_name="recQ_fam"
                     /note="ATP-dependent DNA helicase, RecQ family; TIGR00614"
                     /db_xref="CDD:129701"
     Region          559..638
                     /region_name="HRDC"
                     /note="Helicase and RNase D C-terminal; smart00341"
                     /db_xref="CDD:128635"
     CDS             1..763
                     /gene="BLM"
                     /gene_synonym="BS; MGRISCE1; RECQ2; RECQL2; RECQL3"
                     /coded_by="XM_006720632.3:1304..3595"
                     /db_xref="GeneID:641"
                     /db_xref="HGNC:HGNC:1058"
                     /db_xref="MIM:604610"
ORIGIN      
        1 mmkifhkkfg lhnfrtnqle ainaallged cfilmptggg kslcyqlpac vspgvtvvis
       61 plrslivdqv qkltsldipa tyltgdktds eatniylqls kkdpiiklly vtpekicasn
      121 rlistlenly erkllarfvi deahcvsqwg hdfrqdykrm nmlrqkfpsv pvmaltatan
      181 prvqkdiltq lkilrpqvfs msfnrhnlky yvlpkkpkkv afdclewirk hhpydsgiiy
      241 clsrrecdtm adtlqrdgla alayhaglsd sardevqqkw inqdgcqvic atiafgmgid
      301 kpdvrfviha slpksvegyy qesgragrdg eishcllfyt yhdvtrlkrl immekdgnhh
      361 trethfnnly smvhycenit ecrriqllay fgengfnpdf ckkhpdvscd nccktkdykt
      421 rdvtddvksi vrfvqehsss qgmrnikhvg psgrftmnml vdiflgsksa kiqsgifgkg
      481 saysrhnaer lfkklildki ldedlyinan dqaiayvmlg nkaqtvlngn lkvdfmeten
      541 sssvkkqkal vakvsqreem vkkclgelte vckslgkvfg vhyfnifntv tlkklaesls
      601 sdpevllqid gvtedkleky gaevisvlqk ysewtspaed sspgislsss rgpgrsaaee
      661 ldeeipvssh yfasktrner krkkmpasqr skrrktassg skakggsatc rkissktkss
      721 siigsssash tsqatsgans klgimappkp inrpflkpsy afs
//
LOCUS       XP_016877967             683 aa            linear   PRI 05-AUG-2025
DEFINITION  receptor for retinol uptake STRA6 isoform X1 [Homo sapiens].
ACCESSION   XP_016877967
VERSION     XP_016877967.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022478.2
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 2% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..683
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..683
                     /product="receptor for retinol uptake STRA6 isoform X1"
                     /calculated_mol_wt=75243
     Region          57..673
                     /region_name="RBP_receptor"
                     /note="Retinol binding protein receptor; pfam14752"
                     /db_xref="CDD:464298"
     CDS             1..683
                     /gene="STRA6"
                     /gene_synonym="MCOPCB8; MCOPS9; PP14296; SLC69A1"
                     /coded_by="XM_017022478.2:370..2421"
                     /db_xref="GeneID:64220"
                     /db_xref="HGNC:HGNC:30650"
                     /db_xref="MIM:610745"
ORIGIN      
        1 mafffsrlgs kekgqrmssq pagnqtspga tedysygswy idepqggeel qpegevpsch
       61 tsippglyha claslsilvl lllamlvrrr qlwpdcvrgr pglpspvdfl agdrpravpa
      121 avfmvllssl clllpdedal pfltlasaps qdgkteaprg awkilglfyy aalyyplaac
      181 ataghtaahl lgstlswahl gvqvwqraec pqvpkiykyy sllaslplll glgflslwyp
      241 vqlvrsfsrr tgagskglqs syseeylrnl lcrkklgssy htskhgflsw arvclrhciy
      301 tpqpgfhlpl klvlsatltg taiyqvalll lvgvvptiqk vragvttdvs yllagfgivl
      361 sedkqevvel vkhhlwalev cyisalvlsc lltflvlmrs lvthrtnlra lhrgaaldls
      421 plhrsphpsr qaifcwmsfs ayqtaficlg llvqqiiffl gttalaflvl mpvlhgrnll
      481 lfrslesswp fwltlalavi lqnmaahwvf lethdghpql tnrrvlyaat fllfplnvlv
      541 gamvatwrvl lsalynaihl gqmdlsllpp raatldpgyy tyrnflkiev sqshpamtaf
      601 cslllqaqsl lprtmaapqd slrpgeedeg mqllqtkdsm akgarpgasr grarwglayt
      661 llhnptlqvf rktallgang aqp
//
LOCUS       XP_016877968             667 aa            linear   PRI 05-AUG-2025
DEFINITION  receptor for retinol uptake STRA6 isoform X2 [Homo sapiens].
ACCESSION   XP_016877968
VERSION     XP_016877968.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022479.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..667
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..667
                     /product="receptor for retinol uptake STRA6 isoform X2"
                     /calculated_mol_wt=73372
     Region          41..657
                     /region_name="RBP_receptor"
                     /note="Retinol binding protein receptor; pfam14752"
                     /db_xref="CDD:464298"
     CDS             1..667
                     /gene="STRA6"
                     /gene_synonym="MCOPCB8; MCOPS9; PP14296; SLC69A1"
                     /coded_by="XM_017022479.2:181..2184"
                     /db_xref="GeneID:64220"
                     /db_xref="HGNC:HGNC:30650"
                     /db_xref="MIM:610745"
ORIGIN      
        1 mssqpagnqt spgatedysy gswyidepqg geelqpegev pschtsippg lyhaclasls
       61 ilvllllaml vrrrqlwpdc vrgrpglpsp vdflagdrpr avpaavfmvl lsslclllpd
      121 edalpfltla sapsqdgkte aprgawkilg lfyyaalyyp laacataght aahllgstls
      181 wahlgvqvwq raecpqvpki ykyysllasl plllglgfls lwypvqlvrs fsrrtgagsk
      241 glqssyseey lrnllcrkkl gssyhtskhg flswarvclr hciytpqpgf hlplklvlsa
      301 tltgtaiyqv allllvgvvp tiqkvragvt tdvsyllagf givlsedkqe vvelvkhhlw
      361 alevcyisal vlsclltflv lmrslvthrt nlralhrgaa ldlsplhrsp hpsrqaifcw
      421 msfsayqtaf iclgllvqqi ifflgttala flvlmpvlhg rnlllfrsle sswpfwltla
      481 lavilqnmaa hwvflethdg hpqltnrrvl yaatfllfpl nvlvgamvat wrvllsalyn
      541 aihlgqmdls llppraatld pgyytyrnfl kievsqshpa mtafcslllq aqsllprtma
      601 apqdslrpge edegmqllqt kdsmakgarp gasrgrarwg laytllhnpt lqvfrktall
      661 gangaqp
//
LOCUS       XP_011520187             437 aa            linear   PRI 05-AUG-2025
DEFINITION  receptor for retinol uptake STRA6 isoform X3 [Homo sapiens].
ACCESSION   XP_011520187
VERSION     XP_011520187.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521885.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..437
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..437
                     /product="receptor for retinol uptake STRA6 isoform X3"
                     /calculated_mol_wt=47738
     Region          80..>403
                     /region_name="RBP_receptor"
                     /note="Retinol binding protein receptor; pfam14752"
                     /db_xref="CDD:464298"
     CDS             1..437
                     /gene="STRA6"
                     /gene_synonym="MCOPCB8; MCOPS9; PP14296; SLC69A1"
                     /coded_by="XM_011521885.3:269..1582"
                     /db_xref="GeneID:64220"
                     /db_xref="HGNC:HGNC:30650"
                     /db_xref="MIM:610745"
ORIGIN      
        1 mggkgggdtr gpvlfpcqla qalsprrafp relkekgqrm ssqpagnqts pgatedysyg
       61 swyidepqgg eelqpegevp schtsippgl yhaclaslsi lvllllamlv rrrqlwpdcv
      121 rgrpglpspv dflagdrpra vpaavfmvll sslclllpde dalpfltlas apsqdgktea
      181 prgawkilgl fyyaalyypl aacataghta ahllgstlsw ahlgvqvwqr aecpqvpkiy
      241 kyysllaslp lllglgflsl wypvqlvrsf srrtgagskg lqssyseeyl rnllcrkklg
      301 ssyhtskhgf lswarvclrh ciytpqpgfh lplklvlsat ltgtaiyqva llllvgvvpt
      361 iqkvragvtt dvsyllagfg ivlsedkqev velvkhhlwa levhtdvdsh plcperrplv
      421 qtwmgpygsh ypeswaa
//
LOCUS       XP_016877970             522 aa            linear   PRI 05-AUG-2025
DEFINITION  golgin subfamily A member 6-like protein 4 isoform X1 [Homo
            sapiens].
ACCESSION   XP_016877970
VERSION     XP_016877970.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022481.2
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 2% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..522
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..522
                     /product="golgin subfamily A member 6-like protein 4
                     isoform X1"
                     /calculated_mol_wt=60734
     Region          83..>198
                     /region_name="GOLGA2L5"
                     /note="Putative golgin subfamily A member 2-like protein
                     5; pfam15070"
                     /db_xref="CDD:464485"
     CDS             1..522
                     /gene="GOLGA6L4"
                     /coded_by="XM_017022481.2:63..1631"
                     /db_xref="GeneID:643707"
                     /db_xref="HGNC:HGNC:27256"
ORIGIN      
        1 mwpqprfpph pamsektqqg klaaakkklk aywqrkspgi paganrkkki ngsspdtats
       61 ggyhspgdsa tgiygegras sttledlesq yqelavalds ssaiisqlte ninslvrtsk
      121 eekkheihlv qklgrslfkl knqtaeplap eppagpskve qlqdetnhlr kelesvgrql
      181 qaevennqml sllnrrqeer lreqeerlre qeerlreqed rlheqeerlr eqeerlceqe
      241 erlreheerl ceqeerlceq eerlreqeer lheqeerlre qeerlceqee rlreqeerlc
      301 eqeerlreqe erlceqeklp gqerlleeve klleqerrqe eqerllerer lldeveelld
      361 eveelleqer lrqqderlwq qetlqelerl relerlrele rmlelgweal yeqraeprsg
      421 feelnnenks tlqleqqvke lkksggaeep rgsesaaaar pvagapvpqg awmcgqagwt
      481 pqehpglsge avgtgeaagg ageaachsfr aaenrelnit ii
//
LOCUS       XP_016877971             522 aa            linear   PRI 05-AUG-2025
DEFINITION  golgin subfamily A member 6-like protein 4 isoform X2 [Homo
            sapiens].
ACCESSION   XP_016877971
VERSION     XP_016877971.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022482.2
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 2% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..522
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..522
                     /product="golgin subfamily A member 6-like protein 4
                     isoform X2"
                     /calculated_mol_wt=60734
     Region          83..>198
                     /region_name="GOLGA2L5"
                     /note="Putative golgin subfamily A member 2-like protein
                     5; pfam15070"
                     /db_xref="CDD:464485"
     CDS             1..522
                     /gene="GOLGA6L4"
                     /coded_by="XM_017022482.2:63..1631"
                     /db_xref="GeneID:643707"
                     /db_xref="HGNC:HGNC:27256"
ORIGIN      
        1 mwpqprfpph pamsektqqg klaaakkklk aywqrkspgi paganrkkki ngsspdtats
       61 ggyhspgdsa tgiygegras sttledlesq yqelavalds ssaiisqlte ninslvrtsk
      121 eekkheihlv qklgrslfkl knqtaeplap eppagpskve qlqdetnhlr kelesvgrql
      181 qaevennqml sllnrrqeer lreqeerlre qeerlreqed rlheqeerlr eqeerlceqe
      241 erlreheerl ceqeerlceq eerlreqeer lheqeerlre qeerlceqee rlreqeerlc
      301 eqeerlreqe erlceqeklp gqerlleeve klleqerrqe eqerllerer lldeveelld
      361 eveelleqer lrqqderlwq qetlqelerl relerlrele rmlelgweal yeqraeprsg
      421 feelnnenks tlqleqqvke lkksggaeep rgsesaaaar pvagapvpqg awmcgqagwt
      481 pqehpglsge avgtgeaagg ageaachsfr aaenrelnit ii
//
LOCUS       XP_047288892            1752 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 106 isoform X1 [Homo sapiens].
ACCESSION   XP_047288892
VERSION     XP_047288892.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432936.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1752
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1752
                     /product="zinc finger protein 106 isoform X1"
                     /calculated_mol_wt=194623
     Region          1394..1671
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cd00200"
                     /db_xref="CDD:238121"
     Site            order(1399,1415,1419,1425..1426,1438..1439,1460,1464,
                     1470..1471,1483,1498,1503,1509..1510,1523,1543,1548,
                     1554..1555,1567..1568,1584,1588,1594..1595,1607..1608,
                     1623,1628,1634..1635,1647..1648,1664,1668)
                     /site_type="active"
                     /note="structural tetrad [active]"
                     /db_xref="CDD:238121"
     Region          1444..1483
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1487..1521
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1529..1566
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1572..1606
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1614..1646
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          1652..1672
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..1752
                     /gene="ZNF106"
                     /gene_synonym="SH3BP3; ZFP106; ZNF474"
                     /coded_by="XM_047432936.1:195..5453"
                     /db_xref="GeneID:64397"
                     /db_xref="HGNC:HGNC:12886"
                     /db_xref="MIM:603988"
ORIGIN      
        1 mvrerkcilc hivysskkem dehmrsmlhh relenlkgrq depsnsnqei nsddrrpqwr
       61 redripyqdr esysqpawhh rgppqrdwkw ekdgfnntrk nsfphslrng ggprgrsgwh
      121 kgvaggsstw fhnhsnsggg wlsnsgavdw nhngtgrnss wlsegtggfs swhmnnsngn
      181 wkssvrstnn wnysgpgdkf qpgrnrnsnc qmedmtmlwn kksnksnkys hdrynwqrqe
      241 ndklgtvaty rgpsegftsd kfpseglldf nfeqlesqtt kqadtatskv sgkngsaare
      301 kprrwtpyps qktldlqsgl kditgnksem iekplfdfsl ittgiqepqt detrnsptqk
      361 tqkeihtgsl nhkassdsaa sfevvrqcpt aekpeqehtp nkmpslkspl lpcpatksls
      421 qkqdpknisk ntktnffspg ehsnpsnkpt vednhgpyis klrsscphvl kgnkstfgsq
      481 kqsgdnlndt lrkakevlqc heslqnplls tskstrnyak asrnveesek gslkiefqvh
      541 aledesdget sdtekhgtki gtlgsattel lsgstrtade keeddrilkt srelstspcn
      601 pivrqkesel qmtsaasphp gllldlktsl edaqvddsik shvsyetegf esasldaelq
      661 ksdisqpsgp llpelsklgf paslqrdltr hislksktgv hlpepnlnsa rrirnisghr
      721 ksetekesgl kptlrqilna srrnvnweqv iqqvtkkkqe lgkglprfgi emvplvqneq
      781 ealdldgepd lsslegfqwe gvsissspgl arkrslsess vimdrapsvy sffseegtgk
      841 enepqqmvsp snslragqsq katmhlkqev tpraaslrtg eraenvatqr rhsaqlssdh
      901 iiplmhlakd lnsqersipp senqnsqesn gegnclsssa ssalaissla daatdsscts
      961 gaeqndgqsi rkkrratgdg sspelpsler knkrrkikgk kersqvdqll nislreeels
     1021 kslqcmdnnl lqaraalqta yvevqrllml kqqitmemsa lrthriqilq glqetyepse
     1081 hpdqvpcslt rerrnsrsqt sidaallptp ffplflepps shvspsptga slqittsptf
     1141 qthgsvpapd ssvqikqepm speqdenvna vppssacnvs kelleanktp lekephspad
     1201 qpeqqaestl tsaetrgskk kkklrkkksl raahvpensd teqdvltvkp vrkvkagkli
     1261 kggkvttstw edsrtgreqe svrdepdsds slevleipnp qlevvaidss esgeekpdsp
     1321 skkdiwnste qnpletsrsg cdevsstsei gtrykdgipv svaetqtvis sikgsknsse
     1381 issepgddde ptegsfeghq aavnaiqifg nllytcsadk tvrvynlvsr kcigvfeght
     1441 skvncllvtq tsgknaalyt gssdhtircy nvksrecveq lqledrvlcl hsrwrilyag
     1501 langtvvtfn iknnkrleif echgpravsc lataqegark llvvgsydct isvrdarngl
     1561 llrtleghsk tilcmkvvnd lvfsgssdqs vhahnihtge lvriykghnh avtvvnilgk
     1621 vmvtacldkf vrvyelqshd rlqvygghkd mimcmtihks miytgcydgs iqavrlnlmq
     1681 nyrcwwhgcs lifgvvdhlk qhlltdhtnp nfqtlkcrwk ncdafftark gskqdaaghi
     1741 erhaeddski ds
//
LOCUS       XP_047288893             589 aa            linear   PRI 05-AUG-2025
DEFINITION  kelch-like protein 25 isoform X1 [Homo sapiens].
ACCESSION   XP_047288893
VERSION     XP_047288893.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432937.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..589
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..589
                     /product="kelch-like protein 25 isoform X1"
                     /calculated_mol_wt=65792
     Region          24..151
                     /region_name="BTB_POZ_KLHL25"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in Kelch-like
                     protein 25 (KLHL25); cd18254"
                     /db_xref="CDD:349563"
     Region          39..566
                     /region_name="PHA03098"
                     /note="kelch-like protein; Provisional"
                     /db_xref="CDD:222983"
     Region          144..242
                     /region_name="BACK_KLHL25_ENC2"
                     /note="BACK (BTB and C-terminal Kelch) domain found in
                     Kelch-like protein 25 (KLHL25); cd18514"
                     /db_xref="CDD:350589"
     Region          330..374
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          378..431
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          434..480
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          482..524
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     CDS             1..589
                     /gene="KLHL25"
                     /gene_synonym="ENC-2; ENC2"
                     /coded_by="XM_047432937.1:96..1865"
                     /db_xref="GeneID:64410"
                     /db_xref="HGNC:HGNC:25732"
                     /db_xref="MIM:619893"
ORIGIN      
        1 msvsvhetrk srsstgsmnv tlfhkashpd cvlahlntlr khcmftdvtl wagdrafpch
       61 ravlaassry feamfshglr esrddtvnfq dnlhpevlel lldfayssri aineenaesl
      121 leagdmlqfh dvrdaaaefl eknlfpsncl gmmllsdahq crrlyefswr mclvhfetvr
      181 qsedfnslsk dtlldlissd eletedervv feailqwvkh dleprkvhlp ellrsvrlal
      241 lpsdclqeav sseallmade rtklimdeal rcktrilqnd gvvtspcarp rkaghtllil
      301 ggqtfmcdki yqvdhkakei ipkadlpspr kefsasaigc kvyvtggrgs engvskdvwv
      361 ydtvheewsk aapmliarfg hgsaelencl yvvgghtsla gvfpaspsvs lkqvekydpg
      421 ankwmmvapl rdgvsnaavv saklklfvfg gtsihrdmvs kvqcydpsen rwtikaecpq
      481 pwrytaaavl gsqifimggd teftaasayr fdcetnqwtr igdmtakrms chalasgnkl
      541 yvvggyfgtq rcktldcydp tsdtwncitt vpysliptaf vstwkhlpa
//
LOCUS       XP_047288894             589 aa            linear   PRI 05-AUG-2025
DEFINITION  kelch-like protein 25 isoform X1 [Homo sapiens].
ACCESSION   XP_047288894
VERSION     XP_047288894.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432938.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..589
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..589
                     /product="kelch-like protein 25 isoform X1"
                     /calculated_mol_wt=65792
     Region          24..151
                     /region_name="BTB_POZ_KLHL25"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in Kelch-like
                     protein 25 (KLHL25); cd18254"
                     /db_xref="CDD:349563"
     Region          39..566
                     /region_name="PHA03098"
                     /note="kelch-like protein; Provisional"
                     /db_xref="CDD:222983"
     Region          144..242
                     /region_name="BACK_KLHL25_ENC2"
                     /note="BACK (BTB and C-terminal Kelch) domain found in
                     Kelch-like protein 25 (KLHL25); cd18514"
                     /db_xref="CDD:350589"
     Region          330..374
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          378..431
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          434..480
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          482..524
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     CDS             1..589
                     /gene="KLHL25"
                     /gene_synonym="ENC-2; ENC2"
                     /coded_by="XM_047432938.1:8477..10246"
                     /db_xref="GeneID:64410"
                     /db_xref="HGNC:HGNC:25732"
                     /db_xref="MIM:619893"
ORIGIN      
        1 msvsvhetrk srsstgsmnv tlfhkashpd cvlahlntlr khcmftdvtl wagdrafpch
       61 ravlaassry feamfshglr esrddtvnfq dnlhpevlel lldfayssri aineenaesl
      121 leagdmlqfh dvrdaaaefl eknlfpsncl gmmllsdahq crrlyefswr mclvhfetvr
      181 qsedfnslsk dtlldlissd eletedervv feailqwvkh dleprkvhlp ellrsvrlal
      241 lpsdclqeav sseallmade rtklimdeal rcktrilqnd gvvtspcarp rkaghtllil
      301 ggqtfmcdki yqvdhkakei ipkadlpspr kefsasaigc kvyvtggrgs engvskdvwv
      361 ydtvheewsk aapmliarfg hgsaelencl yvvgghtsla gvfpaspsvs lkqvekydpg
      421 ankwmmvapl rdgvsnaavv saklklfvfg gtsihrdmvs kvqcydpsen rwtikaecpq
      481 pwrytaaavl gsqifimggd teftaasayr fdcetnqwtr igdmtakrms chalasgnkl
      541 yvvggyfgtq rcktldcydp tsdtwncitt vpysliptaf vstwkhlpa
//
LOCUS       XP_011520191             355 aa            linear   PRI 05-AUG-2025
DEFINITION  endophilin-A3 isoform X1 [Homo sapiens].
ACCESSION   XP_011520191
VERSION     XP_011520191.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521889.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..355
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..355
                     /product="endophilin-A3 isoform X1"
                     /calculated_mol_wt=40065
     Region          33..255
                     /region_name="BAR_Endophilin_A3"
                     /note="The Bin/Amphiphysin/Rvs (BAR) domain of
                     Endophilin-A3; cd07615"
                     /db_xref="CDD:153299"
     Site            order(46..47,50..51,53..54,57..58,61,65,68..69,97..98,
                     100..101,104..105,108,111..112,116..118,121..122,216..217,
                     219..221,223..224,227,230..231,233..235,237..238,241..242,
                     244..245,248,252)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:153299"
     Site            order(53,61,73,75,160,164,167,172..173,181..182,185,192)
                     /site_type="other"
                     /note="putative membrane interaction site"
                     /db_xref="CDD:153299"
     Region          296..350
                     /region_name="SH3_Endophilin_A"
                     /note="Src homology 3 domain of Endophilin-A; cd11803"
                     /db_xref="CDD:212737"
     Site            order(302,304,307,311,329..330,343,345..346)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212737"
     CDS             1..355
                     /gene="SH3GL3"
                     /gene_synonym="CNSA3; EEN-B2; HsT19371; SH3D2C; SH3P13"
                     /coded_by="XM_011521889.2:447..1514"
                     /db_xref="GeneID:6457"
                     /db_xref="HGNC:HGNC:10832"
                     /db_xref="MIM:603362"
ORIGIN      
        1 mdgifagiic nqanrcltwt sqqlfsekis gaegtkldde fldmerkidv tnkvvaeils
       61 ktteylqpnp ayraklgmln tvskirgqvk ttgypqtegl lgdcmlkygk elgedstfgn
      121 alievgesmk lmaevkdsld invkqtfidp lqllqdkdlk eighhlkkle grrldydykk
      181 krvgkipdee vrqavekfee skelaersmf nflendveqv sqlavfieaa ldyhrqstei
      241 lqelqsklqm risaassvpr reykprpvkr ssselngvst tsvvkttgsn ipmdqpccrg
      301 lydfepenqg elgfkegdii tltnqidenw yegmihgesg ffpinyvevi vplpq
//
LOCUS       XP_016877975             278 aa            linear   PRI 05-AUG-2025
DEFINITION  endophilin-A3 isoform X2 [Homo sapiens].
ACCESSION   XP_016877975
VERSION     XP_016877975.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022486.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..278
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..278
                     /product="endophilin-A3 isoform X2"
                     /calculated_mol_wt=31456
     Region          <1..178
                     /region_name="BAR"
                     /note="The Bin/Amphiphysin/Rvs (BAR) domain, a
                     dimerization module that binds membranes and detects
                     membrane curvature; cl12013"
                     /db_xref="CDD:472257"
     Region          219..273
                     /region_name="SH3_Endophilin_A"
                     /note="Src homology 3 domain of Endophilin-A; cd11803"
                     /db_xref="CDD:212737"
     Site            order(225,227,230,234,252..253,266,268..269)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212737"
     CDS             1..278
                     /gene="SH3GL3"
                     /gene_synonym="CNSA3; EEN-B2; HsT19371; SH3D2C; SH3P13"
                     /coded_by="XM_017022486.3:487..1323"
                     /db_xref="GeneID:6457"
                     /db_xref="HGNC:HGNC:10832"
                     /db_xref="MIM:603362"
ORIGIN      
        1 mlntvskirg qvkttgypqt egllgdcmlk ygkelgedst fgnalievge smklmaevkd
       61 sldinvkqtf idplqllqdk dlkeighhlk klegrrldyd ykkkrvgkip deevrqavek
      121 feeskelaer smfnflendv eqvsqlavfi eaaldyhrqs teilqelqsk lqmrisaass
      181 vprreykprp vkrssselng vsttsvvktt gsnipmdqpc crglydfepe nqgelgfkeg
      241 diitltnqid enwyegmihg esgffpinyv evivplpq
//
LOCUS       XP_047288896             237 aa            linear   PRI 05-AUG-2025
DEFINITION  endophilin-A3 isoform X3 [Homo sapiens].
ACCESSION   XP_047288896
VERSION     XP_047288896.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432940.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..237
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..237
                     /product="endophilin-A3 isoform X3"
                     /calculated_mol_wt=26826
     Region          33..216
                     /region_name="BAR"
                     /note="The Bin/Amphiphysin/Rvs (BAR) domain, a
                     dimerization module that binds membranes and detects
                     membrane curvature; cl12013"
                     /db_xref="CDD:472257"
     CDS             1..237
                     /gene="SH3GL3"
                     /gene_synonym="CNSA3; EEN-B2; HsT19371; SH3D2C; SH3P13"
                     /coded_by="XM_047432940.1:321..1034"
                     /db_xref="GeneID:6457"
                     /db_xref="HGNC:HGNC:10832"
                     /db_xref="MIM:603362"
ORIGIN      
        1 mdgifagiic nqanrcltwt sqqlfsekis gaegtkldde fldmerkidv tnkvvaeils
       61 ktteylqpnp ayraklgmln tvskirgqvk ttgypqtegl lgdcmlkygk elgedstfgn
      121 alievgesmk lmaevkdsld invkqtfidp lqllqdkdlk eighhlkkle grrldydykk
      181 krvgkipdee vrqavekfee skelaersmf nflendnisc iqcpqtriqa kacekef
//
LOCUS       XP_011520194             217 aa            linear   PRI 05-AUG-2025
DEFINITION  endophilin-A3 isoform X4 [Homo sapiens].
ACCESSION   XP_011520194
VERSION     XP_011520194.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521892.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..217
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..217
                     /product="endophilin-A3 isoform X4"
                     /calculated_mol_wt=24546
     Region          33..217
                     /region_name="BAR"
                     /note="The Bin/Amphiphysin/Rvs (BAR) domain, a
                     dimerization module that binds membranes and detects
                     membrane curvature; cl12013"
                     /db_xref="CDD:472257"
     CDS             1..217
                     /gene="SH3GL3"
                     /gene_synonym="CNSA3; EEN-B2; HsT19371; SH3D2C; SH3P13"
                     /coded_by="XM_011521892.3:321..974"
                     /db_xref="GeneID:6457"
                     /db_xref="HGNC:HGNC:10832"
                     /db_xref="MIM:603362"
ORIGIN      
        1 mdgifagiic nqanrcltwt sqqlfsekis gaegtkldde fldmerkidv tnkvvaeils
       61 ktteylqpnp ayraklgmln tvskirgqvk ttgypqtegl lgdcmlkygk elgedstfgn
      121 alievgesmk lmaevkdsld invkqtfidp lqllqdkdlk eighhlkkle grrldydykk
      181 krvgkipdee vrqavekfee skelaersmf nflendl
//
LOCUS       XP_011520195             969 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein basonuclin-1 isoform X1 [Homo sapiens].
ACCESSION   XP_011520195
VERSION     XP_011520195.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521893.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..969
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..969
                     /product="zinc finger protein basonuclin-1 isoform X1"
                     /calculated_mol_wt=107776
     Region          334..355
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          362..380
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          905..926
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275370"
     Site            order(910,912,914,916..917,920..921,924,940,942..944,
                     946..947,951)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275370"
     Region          933..951
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275370"
     CDS             1..969
                     /gene="BNC1"
                     /gene_synonym="bn1; BNC; BSN1; HsT19447; POF16"
                     /coded_by="XM_011521893.2:972..3881"
                     /db_xref="GeneID:646"
                     /db_xref="HGNC:HGNC:1081"
                     /db_xref="MIM:601930"
ORIGIN      
        1 mpspslncai sctlncscqs fkpgkinhrq cdqckhgwva halsklripp myptsqveiv
       61 qsnvvfdiss lmlygtqaip vrlkilldrl fsvlkqdevl qilhaldwtl qdyirgyvlq
      121 dasgkvldhw simtseeeva tlqqflrfge tksivelmai qekeeqsiii ppstanvdir
      181 afiescshrs sslptpvdkg npssihpfen lisnmtfmlp fqffnplppa ligslpeqym
      241 leqghdqsqd pkqevhgpfp dssfltssst pfqvekdqcl ncpdaitkke dsthlsdsss
      301 ynivtkfert qlspeakvkp ernslgtkkg rvfctacekt fydkgtlkih ynavhlkikh
      361 kctiegcnmv fsslrsrnrh sanpnprlhm pmnrnnrdkd lrnslnlass enykcpgftv
      421 tspdcrppps ypgsgedskg qpafpnigqn gvlfpnlktv qpvlpfyrsp atpaevantp
      481 gilpslplls ssipeqlisn empfdalpkk ksrkssmpik iekeaveian ekrhnlssde
      541 dmplqvvsed eqeacspqsh rvseeqhvqs gglgkpfpeg erpchresvi essgaisqtp
      601 eqathnsere teqtpalimv prevedgghe hyftpgmepq vpfsdymelq qrllagglfs
      661 alsnrgmafp cledskeleh vgqhalarqi eenrfqcdic kktfknacsv kihhknmhvk
      721 emhtctvegc natfpsrrsr drhssnlnlh qkalsqeale ssedhfraay llkdvakeay
      781 qdvaftqqas qtsvifkgts rmgslvypit qvhsaslesy nsgplsegti ldlsttssmk
      841 sessshsswd sdgvseegtv lmedsdgnce gsslvpgede ypicvlmeka dqslaslpsg
      901 lpitchlcqk tysnkgtfra hyktvhlrql hkckvpgcnt mfssvrsrnr hsqnpnlhks
      961 lasspshlq
//
LOCUS       XP_011520196             876 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein basonuclin-1 isoform X2 [Homo sapiens].
ACCESSION   XP_011520196
VERSION     XP_011520196.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521894.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..876
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..876
                     /product="zinc finger protein basonuclin-1 isoform X2"
                     /calculated_mol_wt=97161
     Region          241..262
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          269..287
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          812..833
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275370"
     Site            order(817,819,821,823..824,827..828,831,847,849..851,
                     853..854,858)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275370"
     Region          840..858
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275370"
     CDS             1..876
                     /gene="BNC1"
                     /gene_synonym="bn1; BNC; BSN1; HsT19447; POF16"
                     /coded_by="XM_011521894.1:261..2891"
                     /db_xref="GeneID:646"
                     /db_xref="HGNC:HGNC:1081"
                     /db_xref="MIM:601930"
ORIGIN      
        1 mskfgknfne mggehisktn idvsltedas gkvldhwsim tseeevatlq qflrfgetks
       61 ivelmaiqek eeqsiiipps tanvdirafi escshrsssl ptpvdkgnps sihpfenlis
      121 nmtfmlpfqf fnplppalig slpeqymleq ghdqsqdpkq evhgpfpdss fltssstpfq
      181 vekdqclncp daitkkedst hlsdsssyni vtkfertqls peakvkpern slgtkkgrvf
      241 ctacektfyd kgtlkihyna vhlkikhkct iegcnmvfss lrsrnrhsan pnprlhmpmn
      301 rnnrdkdlrn slnlasseny kcpgftvtsp dcrpppsypg sgedskgqpa fpnigqngvl
      361 fpnlktvqpv lpfyrspatp aevantpgil pslpllsssi peqlisnemp fdalpkkksr
      421 kssmpikiek eaveianekr hnlssdedmp lqvvsedeqe acspqshrvs eeqhvqsggl
      481 gkpfpegerp chresviess gaisqtpeqa thnsereteq tpalimvpre vedgghehyf
      541 tpgmepqvpf sdymelqqrl lagglfsals nrgmafpcle dskelehvgq halarqieen
      601 rfqcdickkt fknacsvkih hknmhvkemh tctvegcnat fpsrrsrdrh ssnlnlhqka
      661 lsqealesse dhfraayllk dvakeayqdv aftqqasqts vifkgtsrmg slvypitqvh
      721 saslesynsg plsegtildl sttssmkses sshsswdsdg vseegtvlme dsdgncegss
      781 lvpgedeypi cvlmekadqs laslpsglpi tchlcqktys nkgtfrahyk tvhlrqlhkc
      841 kvpgcntmfs svrsrnrhsq npnlhkslas spshlq
//
LOCUS       XP_016877976             432 aa            linear   PRI 05-AUG-2025
DEFINITION  SH2 domain-containing protein 7 isoform X1 [Homo sapiens].
ACCESSION   XP_016877976
VERSION     XP_016877976.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022487.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XP_016877976.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..432
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..432
                     /product="SH2 domain-containing protein 7 isoform X1"
                     /calculated_mol_wt=47491
     Region          <54..125
                     /region_name="SH2"
                     /note="Src homology 2 (SH2) domain; cl15255"
                     /db_xref="CDD:472789"
     Site            order(78,106)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:199832"
     CDS             1..432
                     /gene="SH2D7"
                     /coded_by="XM_017022487.2:40..1338"
                     /db_xref="GeneID:646892"
                     /db_xref="HGNC:HGNC:34549"
ORIGIN      
        1 mgkmwlrdek elrrsrpswl trrssysgtk llvpslsasv teplatscpt geilgrilty
       61 krdqsgtaqr gsdrcrhfvi nqlrnrryii sgdtqshstl aelvhhyqea qlepfkemlt
      121 aacprpednd lydaitrglh qtivdpenpp atafltvvpd kaasprsspk pqvsflhaqk
      181 sldvsprnls qeesmeapir vsplpeksss lleesfggps diiyadlrrm nqarlglgte
      241 gsgrhgpvpa gsqayspgre aqrrlsdgeq nrpdglgpvl sgvspdqgpt esptswgcsd
      301 amgslgatwr qefpklsqea qpcsqgssad iyefigtegl lqeardtpdq egstyeqipa
      361 cwggparaph pgasptyspw vhgykrisgt pelsepgnty eqipatkske tgrthkpdkl
      421 rrlfftyrkh kf
//
LOCUS       XP_047288898             418 aa            linear   PRI 05-AUG-2025
DEFINITION  SH2 domain-containing protein 7 isoform X2 [Homo sapiens].
ACCESSION   XP_047288898
VERSION     XP_047288898.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432942.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 7% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..418
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..418
                     /product="SH2 domain-containing protein 7 isoform X2"
                     /calculated_mol_wt=45509
     Region          <40..111
                     /region_name="SH2"
                     /note="Src homology 2 (SH2) domain; cl15255"
                     /db_xref="CDD:472789"
     Site            order(64,92)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:199832"
     CDS             1..418
                     /gene="SH2D7"
                     /coded_by="XM_047432942.1:182..1438"
                     /db_xref="GeneID:646892"
                     /db_xref="HGNC:HGNC:34549"
ORIGIN      
        1 mdsspasrrs sysgtkllvp slsasvtepl atscptgeil griltykrdq sgtaqrgsdr
       61 crhfvinqlr nrryiisgdt qshstlaelv hhyqeaqlep fkemltaacp rpedndlyda
      121 itrglhqtiv dpenppataf ltvvpdkaas prsspkpqvs flhaqksldv sprnlsqees
      181 meapirvspl peksssllee sfggpsdiiy adlrrmnqar lglgtegsgr hgpvpagsqa
      241 yspgreaqrr lsdgeqnrpd glgpvlsgvs pdqgptespt swgcsdamgs lgatwrqefp
      301 klsqeaqpcs qgssadiyef igtegllqea rdtpdqegst yeqipacwgg paraphpgas
      361 ptyspwvhgy krisgtpels epgntyeqip atksketgrt hkpdklrrlf ftyrkhkf
//
LOCUS       XP_047288899             338 aa            linear   PRI 05-AUG-2025
DEFINITION  SH2 domain-containing protein 7 isoform X3 [Homo sapiens].
ACCESSION   XP_047288899
VERSION     XP_047288899.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432943.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..338
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..338
                     /product="SH2 domain-containing protein 7 isoform X3"
                     /calculated_mol_wt=36450
     CDS             1..338
                     /gene="SH2D7"
                     /coded_by="XM_047432943.1:415..1431"
                     /db_xref="GeneID:646892"
                     /db_xref="HGNC:HGNC:34549"
ORIGIN      
        1 mlqsltsslr qaagdwlgmc dhipavsacs qpedndlyda itrglhqtiv dpenppataf
       61 ltvvpdkaas prsspkpqvs flhaqksldv sprnlsqees meapirvspl peksssllee
      121 sfggpsdiiy adlrrmnqar lglgtegsgr hgpvpagsqa yspgreaqrr lsdgeqnrpd
      181 glgpvlsgvs pdqgptespt swgcsdamgs lgatwrqefp klsqeaqpcs qgssadiyef
      241 igtegllqea rdtpdqegst yeqipacwgg paraphpgas ptyspwvhgy krisgtpels
      301 epgntyeqip atksketgrt hkpdklrrlf ftyrkhkf
//
LOCUS       XP_047288900             338 aa            linear   PRI 05-AUG-2025
DEFINITION  SH2 domain-containing protein 7 isoform X3 [Homo sapiens].
ACCESSION   XP_047288900
VERSION     XP_047288900.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432944.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..338
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..338
                     /product="SH2 domain-containing protein 7 isoform X3"
                     /calculated_mol_wt=36450
     CDS             1..338
                     /gene="SH2D7"
                     /coded_by="XM_047432944.1:413..1429"
                     /db_xref="GeneID:646892"
                     /db_xref="HGNC:HGNC:34549"
ORIGIN      
        1 mlqsltsslr qaagdwlgmc dhipavsacs qpedndlyda itrglhqtiv dpenppataf
       61 ltvvpdkaas prsspkpqvs flhaqksldv sprnlsqees meapirvspl peksssllee
      121 sfggpsdiiy adlrrmnqar lglgtegsgr hgpvpagsqa yspgreaqrr lsdgeqnrpd
      181 glgpvlsgvs pdqgptespt swgcsdamgs lgatwrqefp klsqeaqpcs qgssadiyef
      241 igtegllqea rdtpdqegst yeqipacwgg paraphpgas ptyspwvhgy krisgtpels
      301 epgntyeqip atksketgrt hkpdklrrlf ftyrkhkf
//
LOCUS       XP_005255023             325 aa            linear   PRI 05-AUG-2025
DEFINITION  apoptosis-enhancing nuclease isoform X1 [Homo sapiens].
ACCESSION   XP_005255023
VERSION     XP_005255023.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254966.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..325
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..325
                     /product="apoptosis-enhancing nuclease isoform X1"
                     /calculated_mol_wt=36219
     Region          111..267
                     /region_name="DnaQ_like_exo"
                     /note="DnaQ-like (or DEDD) 3'-5' exonuclease domain
                     superfamily; cl10012"
                     /db_xref="CDD:447876"
     Site            order(114..117,193..194,196..198,258)
                     /site_type="active"
                     /db_xref="CDD:99852"
     Site            order(114,116,198,258)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:99852"
     Site            order(115..117,193..194,196..197,258)
                     /site_type="other"
                     /note="substrate binding site [chemical binding]"
                     /db_xref="CDD:99852"
     CDS             1..325
                     /gene="AEN"
                     /gene_synonym="ISG20L1; pp12744"
                     /coded_by="XM_005254966.2:389..1366"
                     /db_xref="GeneID:64782"
                     /db_xref="HGNC:HGNC:25722"
                     /db_xref="MIM:610177"
ORIGIN      
        1 mvpreapesa qclcpsltip nakdvlrkrh krrsrqhqrf markallqeq gllsmppepg
       61 ssplptpfga atateaassg kqclragsgs apcsrrpapg kasgplpskc vaidcemvgt
      121 gprgrvsela rcsivsyhgn vlydkyirpe mpiadyrtrw sgitrqhmrk avpfqvaqke
      181 ilkllkgkvv vghalhndfq alkyvhprsq trdttyvpnf lsepglhtra rvslkdlalq
      241 llhkkiqvgq hghssvedat tamelyrlve vqweqqears lwtcpedrep dsstdmeqym
      301 edqywpddla hgsrggarea qdrrn
//
LOCUS       XP_047288901             247 aa            linear   PRI 05-AUG-2025
DEFINITION  apoptosis-enhancing nuclease isoform X2 [Homo sapiens].
ACCESSION   XP_047288901
VERSION     XP_047288901.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432945.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..247
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..247
                     /product="apoptosis-enhancing nuclease isoform X2"
                     /calculated_mol_wt=27168
     Region          111..247
                     /region_name="DnaQ_like_exo"
                     /note="DnaQ-like (or DEDD) 3'-5' exonuclease domain
                     superfamily; cl10012"
                     /db_xref="CDD:447876"
     Site            order(114..117,193..194,196..198)
                     /site_type="active"
                     /db_xref="CDD:99852"
     Site            order(115..117,193..194,196..197)
                     /site_type="other"
                     /note="substrate binding site [chemical binding]"
                     /db_xref="CDD:99852"
     CDS             1..247
                     /gene="AEN"
                     /gene_synonym="ISG20L1; pp12744"
                     /coded_by="XM_047432945.1:389..1132"
                     /db_xref="GeneID:64782"
                     /db_xref="HGNC:HGNC:25722"
                     /db_xref="MIM:610177"
ORIGIN      
        1 mvpreapesa qclcpsltip nakdvlrkrh krrsrqhqrf markallqeq gllsmppepg
       61 ssplptpfga atateaassg kqclragsgs apcsrrpapg kasgplpskc vaidcemvgt
      121 gprgrvsela rcsivsyhgn vlydkyirpe mpiadyrtrw sgitrqhmrk avpfqvaqke
      181 ilkllkgkvv vghalhndfq alkyvhprsq trdttyvpnf lsepglhtra rvslkdlalq
      241 llhkkiq
//
LOCUS       XP_006720708             247 aa            linear   PRI 05-AUG-2025
DEFINITION  apoptosis-enhancing nuclease isoform X2 [Homo sapiens].
ACCESSION   XP_006720708
VERSION     XP_006720708.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720645.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Mar 12, 2015 this sequence version replaced XP_006720708.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..247
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..247
                     /product="apoptosis-enhancing nuclease isoform X2"
                     /calculated_mol_wt=27168
     Region          111..247
                     /region_name="DnaQ_like_exo"
                     /note="DnaQ-like (or DEDD) 3'-5' exonuclease domain
                     superfamily; cl10012"
                     /db_xref="CDD:447876"
     Site            order(114..117,193..194,196..198)
                     /site_type="active"
                     /db_xref="CDD:99852"
     Site            order(115..117,193..194,196..197)
                     /site_type="other"
                     /note="substrate binding site [chemical binding]"
                     /db_xref="CDD:99852"
     CDS             1..247
                     /gene="AEN"
                     /gene_synonym="ISG20L1; pp12744"
                     /coded_by="XM_006720645.4:108..851"
                     /db_xref="GeneID:64782"
                     /db_xref="HGNC:HGNC:25722"
                     /db_xref="MIM:610177"
ORIGIN      
        1 mvpreapesa qclcpsltip nakdvlrkrh krrsrqhqrf markallqeq gllsmppepg
       61 ssplptpfga atateaassg kqclragsgs apcsrrpapg kasgplpskc vaidcemvgt
      121 gprgrvsela rcsivsyhgn vlydkyirpe mpiadyrtrw sgitrqhmrk avpfqvaqke
      181 ilkllkgkvv vghalhndfq alkyvhprsq trdttyvpnf lsepglhtra rvslkdlalq
      241 llhkkiq
//
LOCUS       XP_047288902             325 aa            linear   PRI 05-AUG-2025
DEFINITION  apoptosis-enhancing nuclease isoform X1 [Homo sapiens].
ACCESSION   XP_047288902
VERSION     XP_047288902.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432946.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..325
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..325
                     /product="apoptosis-enhancing nuclease isoform X1"
                     /calculated_mol_wt=36219
     Region          111..267
                     /region_name="DnaQ_like_exo"
                     /note="DnaQ-like (or DEDD) 3'-5' exonuclease domain
                     superfamily; cl10012"
                     /db_xref="CDD:447876"
     Site            order(114..117,193..194,196..198,258)
                     /site_type="active"
                     /db_xref="CDD:99852"
     Site            order(114,116,198,258)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:99852"
     Site            order(115..117,193..194,196..197,258)
                     /site_type="other"
                     /note="substrate binding site [chemical binding]"
                     /db_xref="CDD:99852"
     CDS             1..325
                     /gene="AEN"
                     /gene_synonym="ISG20L1; pp12744"
                     /coded_by="XM_047432946.1:657..1634"
                     /db_xref="GeneID:64782"
                     /db_xref="HGNC:HGNC:25722"
                     /db_xref="MIM:610177"
ORIGIN      
        1 mvpreapesa qclcpsltip nakdvlrkrh krrsrqhqrf markallqeq gllsmppepg
       61 ssplptpfga atateaassg kqclragsgs apcsrrpapg kasgplpskc vaidcemvgt
      121 gprgrvsela rcsivsyhgn vlydkyirpe mpiadyrtrw sgitrqhmrk avpfqvaqke
      181 ilkllkgkvv vghalhndfq alkyvhprsq trdttyvpnf lsepglhtra rvslkdlalq
      241 llhkkiqvgq hghssvedat tamelyrlve vqweqqears lwtcpedrep dsstdmeqym
      301 edqywpddla hgsrggarea qdrrn
//
LOCUS       XP_016877978             325 aa            linear   PRI 05-AUG-2025
DEFINITION  apoptosis-enhancing nuclease isoform X1 [Homo sapiens].
ACCESSION   XP_016877978
VERSION     XP_016877978.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022489.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..325
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..325
                     /product="apoptosis-enhancing nuclease isoform X1"
                     /calculated_mol_wt=36219
     Region          111..267
                     /region_name="DnaQ_like_exo"
                     /note="DnaQ-like (or DEDD) 3'-5' exonuclease domain
                     superfamily; cl10012"
                     /db_xref="CDD:447876"
     Site            order(114..117,193..194,196..198,258)
                     /site_type="active"
                     /db_xref="CDD:99852"
     Site            order(114,116,198,258)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:99852"
     Site            order(115..117,193..194,196..197,258)
                     /site_type="other"
                     /note="substrate binding site [chemical binding]"
                     /db_xref="CDD:99852"
     CDS             1..325
                     /gene="AEN"
                     /gene_synonym="ISG20L1; pp12744"
                     /coded_by="XM_017022489.2:3921..4898"
                     /db_xref="GeneID:64782"
                     /db_xref="HGNC:HGNC:25722"
                     /db_xref="MIM:610177"
ORIGIN      
        1 mvpreapesa qclcpsltip nakdvlrkrh krrsrqhqrf markallqeq gllsmppepg
       61 ssplptpfga atateaassg kqclragsgs apcsrrpapg kasgplpskc vaidcemvgt
      121 gprgrvsela rcsivsyhgn vlydkyirpe mpiadyrtrw sgitrqhmrk avpfqvaqke
      181 ilkllkgkvv vghalhndfq alkyvhprsq trdttyvpnf lsepglhtra rvslkdlalq
      241 llhkkiqvgq hghssvedat tamelyrlve vqweqqears lwtcpedrep dsstdmeqym
      301 edqywpddla hgsrggarea qdrrn
//
LOCUS       XP_047288903             325 aa            linear   PRI 05-AUG-2025
DEFINITION  apoptosis-enhancing nuclease isoform X1 [Homo sapiens].
ACCESSION   XP_047288903
VERSION     XP_047288903.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432947.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..325
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..325
                     /product="apoptosis-enhancing nuclease isoform X1"
                     /calculated_mol_wt=36219
     Region          111..267
                     /region_name="DnaQ_like_exo"
                     /note="DnaQ-like (or DEDD) 3'-5' exonuclease domain
                     superfamily; cl10012"
                     /db_xref="CDD:447876"
     Site            order(114..117,193..194,196..198,258)
                     /site_type="active"
                     /db_xref="CDD:99852"
     Site            order(114,116,198,258)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:99852"
     Site            order(115..117,193..194,196..197,258)
                     /site_type="other"
                     /note="substrate binding site [chemical binding]"
                     /db_xref="CDD:99852"
     CDS             1..325
                     /gene="AEN"
                     /gene_synonym="ISG20L1; pp12744"
                     /coded_by="XM_047432947.1:816..1793"
                     /db_xref="GeneID:64782"
                     /db_xref="HGNC:HGNC:25722"
                     /db_xref="MIM:610177"
ORIGIN      
        1 mvpreapesa qclcpsltip nakdvlrkrh krrsrqhqrf markallqeq gllsmppepg
       61 ssplptpfga atateaassg kqclragsgs apcsrrpapg kasgplpskc vaidcemvgt
      121 gprgrvsela rcsivsyhgn vlydkyirpe mpiadyrtrw sgitrqhmrk avpfqvaqke
      181 ilkllkgkvv vghalhndfq alkyvhprsq trdttyvpnf lsepglhtra rvslkdlalq
      241 llhkkiqvgq hghssvedat tamelyrlve vqweqqears lwtcpedrep dsstdmeqym
      301 edqywpddla hgsrggarea qdrrn
//
LOCUS       XP_047288904            1460 aa            linear   PRI 05-AUG-2025
DEFINITION  DNA-binding protein RFX7 isoform X1 [Homo sapiens].
ACCESSION   XP_047288904
VERSION     XP_047288904.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432948.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1460
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1460
                     /product="DNA-binding protein RFX7 isoform X1"
                     /calculated_mol_wt=157221
     Region          43..100
                     /region_name="RFX5_N"
                     /note="RFX5 N-terminal domain; pfam18326"
                     /db_xref="CDD:375753"
     Region          105..183
                     /region_name="RFX_DNA_binding"
                     /note="RFX DNA-binding domain; pfam02257"
                     /db_xref="CDD:460512"
     Region          <258..568
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          468..>745
                     /region_name="MSCRAMM_ClfA"
                     /note="MSCRAMM family adhesin clumping factor ClfA;
                     NF033609"
                     /db_xref="CDD:468110"
     CDS             1..1460
                     /gene="RFX7"
                     /gene_synonym="MRD71; RFXDC2"
                     /coded_by="XM_047432948.1:263..4645"
                     /db_xref="GeneID:64864"
                     /db_xref="HGNC:HGNC:25777"
                     /db_xref="MIM:612660"
ORIGIN      
        1 maeeqqqppp qqpdahqqlp psapnsgval palvpglpgt easalqhkik nsicktvqsk
       61 vdcilqevek ftdleklyly lqlpsglsng eksdqnamss sraqqmhafs wirntleehp
      121 etslpkqevy deyksycdnl gyhplsaadf gkimknvfpn mkarrlgtrg kskycysglr
      181 kkafvhmptl pnldfhktgd glegaepsgq lqnideevis sacrlvcewa qkvlsqpfdt
      241 vlelarflvk shyigtksma altvmaaapa gmkgitqpsa fiptaesnsf qpqvktlpsp
      301 idakqqlqrk iqkkqqeqkl qsplpgesaa kksesatsng vtnlpngnps ilspqpigiv
      361 vaavpspipv qrtrqlvtsp spmsssdgkv lplnvqvvtq hmqsvkqapk tpqnvpaspg
      421 gdrsarhryp qilpkpants altirspttv lftsspikta vvpashmssl nvvkmttisl
      481 tpsnsntplk hsasvssatg tteesrsvpq ikngsvvslq spgsrsssag gtsavevkve
      541 petssdehpv qcqensdeak apqtpsallg qksntdgalq kpsnegviei katkvcdqrt
      601 kcksrcneml pgtstgnnqs titlsvasqn ltftsssspp ngdsinkdpk lctksprkrl
      661 sstlqetqvp pvkkpiveql saatiegqkq gsvkkdqkvp hsgktegsta gaqipskvsv
      721 nvsshiganq plnssalvis dsaleqqttp ssspdikvkl egsvflldsd sksvgsfnpn
      781 gwqqitkdse fisasceqqq disvmtipeh sdindleksv welegmpqdt ysqqlhsqiq
      841 esslnqiqah ssdqlplqse lkefepsvsq tnesyfpfdd eltqdsivee lvlmeqqmsm
      901 nnshsygncl gmtlqsqsvt pgapmsshts sthfyhpihs ngtpihtptp tptptptptp
      961 tptptsemia gsqslsresp csrlaqttpv dsalgssrht pigtphsncs ssvppspvec
     1021 rnpfaftpis ssmayhdasi vssspvkpmq rpmathpdkt klewmnngys gvgnssvsgh
     1081 gilpsyqelv edrfrkphaf avpgqsyqsq srhhdthfgr ltpvspvqhq gatvnntnkq
     1141 egfavpapld nkgtnssass nfrcrsvspa vhrqrnlsgs tlypvsnipr snvtpfgspv
     1201 tpevhvftnv htdacannia qrsqsvpltv mmqtafpnal qkqanskkit nvllskldsd
     1261 nddavrglgm nnlpsnytar mnltqileps tvfpsanpqn midsstsvye fqtpsyltks
     1321 nstgqinfsp gdnqaqseig eqqldfnstv kdllsgdslq tnqqlvgqga sdltntasdf
     1381 ssdirlssel sgsindlntl dpnllfdpgr qqgqddeatl eelkndplfq qicsesmnsm
     1441 tssgfewies kdhptvemlg
//
LOCUS       XP_047288905            1363 aa            linear   PRI 05-AUG-2025
DEFINITION  DNA-binding protein RFX7 isoform X2 [Homo sapiens].
ACCESSION   XP_047288905
VERSION     XP_047288905.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432949.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1363
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1363
                     /product="DNA-binding protein RFX7 isoform X2"
                     /calculated_mol_wt=146765
     Region          8..86
                     /region_name="RFX_DNA_binding"
                     /note="RFX DNA-binding domain; pfam02257"
                     /db_xref="CDD:460512"
     Region          <161..471
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          371..>648
                     /region_name="MSCRAMM_ClfA"
                     /note="MSCRAMM family adhesin clumping factor ClfA;
                     NF033609"
                     /db_xref="CDD:468110"
     CDS             1..1363
                     /gene="RFX7"
                     /gene_synonym="MRD71; RFXDC2"
                     /coded_by="XM_047432949.1:1479..5570"
                     /db_xref="GeneID:64864"
                     /db_xref="HGNC:HGNC:25777"
                     /db_xref="MIM:612660"
ORIGIN      
        1 msssraqqmh afswirntle ehpetslpkq evydeyksyc dnlgyhplsa adfgkimknv
       61 fpnmkarrlg trgkskycys glrkkafvhm ptlpnldfhk tgdglegaep sgqlqnidee
      121 vissacrlvc ewaqkvlsqp fdtvlelarf lvkshyigtk smaaltvmaa apagmkgitq
      181 psafiptaes nsfqpqvktl pspidakqql qrkiqkkqqe qklqsplpge saakksesat
      241 sngvtnlpng npsilspqpi givvaavpsp ipvqrtrqlv tspspmsssd gkvlplnvqv
      301 vtqhmqsvkq apktpqnvpa spggdrsarh rypqilpkpa ntsaltirsp ttvlftsspi
      361 ktavvpashm sslnvvkmtt isltpsnsnt plkhsasvss atgtteesrs vpqikngsvv
      421 slqspgsrss saggtsavev kvepetssde hpvqcqensd eakapqtpsa llgqksntdg
      481 alqkpsnegv ieikatkvcd qrtkcksrcn emlpgtstgn nqstitlsva sqnltftsss
      541 sppngdsink dpklctkspr krlsstlqet qvppvkkpiv eqlsaatieg qkqgsvkkdq
      601 kvphsgkteg stagaqipsk vsvnvsshig anqplnssal visdsaleqq ttpssspdik
      661 vklegsvfll dsdsksvgsf npngwqqitk dsefisasce qqqdisvmti pehsdindle
      721 ksvwelegmp qdtysqqlhs qiqesslnqi qahssdqlpl qselkefeps vsqtnesyfp
      781 fddeltqdsi veelvlmeqq msmnnshsyg nclgmtlqsq svtpgapmss htssthfyhp
      841 ihsngtpiht ptptptptpt ptptptptse miagsqslsr espcsrlaqt tpvdsalgss
      901 rhtpigtphs ncsssvppsp vecrnpfaft pisssmayhd asivssspvk pmqrpmathp
      961 dktklewmnn gysgvgnssv sghgilpsyq elvedrfrkp hafavpgqsy qsqsrhhdth
     1021 fgrltpvspv qhqgatvnnt nkqegfavpa pldnkgtnss assnfrcrsv spavhrqrnl
     1081 sgstlypvsn iprsnvtpfg spvtpevhvf tnvhtdacan niaqrsqsvp ltvmmqtafp
     1141 nalqkqansk kitnvllskl dsdnddavrg lgmnnlpsny tarmnltqil epstvfpsan
     1201 pqnmidssts vyefqtpsyl tksnstgqin fspgdnqaqs eigeqqldfn stvkdllsgd
     1261 slqtnqqlvg qgasdltnta sdfssdirls selsgsindl ntldpnllfd pgrqqgqdde
     1321 atleelkndp lfqqicsesm nsmtssgfew ieskdhptve mlg
//
LOCUS       XP_047288906            1363 aa            linear   PRI 05-AUG-2025
DEFINITION  DNA-binding protein RFX7 isoform X2 [Homo sapiens].
ACCESSION   XP_047288906
VERSION     XP_047288906.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432950.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1363
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1363
                     /product="DNA-binding protein RFX7 isoform X2"
                     /calculated_mol_wt=146765
     Region          8..86
                     /region_name="RFX_DNA_binding"
                     /note="RFX DNA-binding domain; pfam02257"
                     /db_xref="CDD:460512"
     Region          <161..471
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          371..>648
                     /region_name="MSCRAMM_ClfA"
                     /note="MSCRAMM family adhesin clumping factor ClfA;
                     NF033609"
                     /db_xref="CDD:468110"
     CDS             1..1363
                     /gene="RFX7"
                     /gene_synonym="MRD71; RFXDC2"
                     /coded_by="XM_047432950.1:18647..22738"
                     /db_xref="GeneID:64864"
                     /db_xref="HGNC:HGNC:25777"
                     /db_xref="MIM:612660"
ORIGIN      
        1 msssraqqmh afswirntle ehpetslpkq evydeyksyc dnlgyhplsa adfgkimknv
       61 fpnmkarrlg trgkskycys glrkkafvhm ptlpnldfhk tgdglegaep sgqlqnidee
      121 vissacrlvc ewaqkvlsqp fdtvlelarf lvkshyigtk smaaltvmaa apagmkgitq
      181 psafiptaes nsfqpqvktl pspidakqql qrkiqkkqqe qklqsplpge saakksesat
      241 sngvtnlpng npsilspqpi givvaavpsp ipvqrtrqlv tspspmsssd gkvlplnvqv
      301 vtqhmqsvkq apktpqnvpa spggdrsarh rypqilpkpa ntsaltirsp ttvlftsspi
      361 ktavvpashm sslnvvkmtt isltpsnsnt plkhsasvss atgtteesrs vpqikngsvv
      421 slqspgsrss saggtsavev kvepetssde hpvqcqensd eakapqtpsa llgqksntdg
      481 alqkpsnegv ieikatkvcd qrtkcksrcn emlpgtstgn nqstitlsva sqnltftsss
      541 sppngdsink dpklctkspr krlsstlqet qvppvkkpiv eqlsaatieg qkqgsvkkdq
      601 kvphsgkteg stagaqipsk vsvnvsshig anqplnssal visdsaleqq ttpssspdik
      661 vklegsvfll dsdsksvgsf npngwqqitk dsefisasce qqqdisvmti pehsdindle
      721 ksvwelegmp qdtysqqlhs qiqesslnqi qahssdqlpl qselkefeps vsqtnesyfp
      781 fddeltqdsi veelvlmeqq msmnnshsyg nclgmtlqsq svtpgapmss htssthfyhp
      841 ihsngtpiht ptptptptpt ptptptptse miagsqslsr espcsrlaqt tpvdsalgss
      901 rhtpigtphs ncsssvppsp vecrnpfaft pisssmayhd asivssspvk pmqrpmathp
      961 dktklewmnn gysgvgnssv sghgilpsyq elvedrfrkp hafavpgqsy qsqsrhhdth
     1021 fgrltpvspv qhqgatvnnt nkqegfavpa pldnkgtnss assnfrcrsv spavhrqrnl
     1081 sgstlypvsn iprsnvtpfg spvtpevhvf tnvhtdacan niaqrsqsvp ltvmmqtafp
     1141 nalqkqansk kitnvllskl dsdnddavrg lgmnnlpsny tarmnltqil epstvfpsan
     1201 pqnmidssts vyefqtpsyl tksnstgqin fspgdnqaqs eigeqqldfn stvkdllsgd
     1261 slqtnqqlvg qgasdltnta sdfssdirls selsgsindl ntldpnllfd pgrqqgqdde
     1321 atleelkndp lfqqicsesm nsmtssgfew ieskdhptve mlg
//
LOCUS       XP_047288907            1363 aa            linear   PRI 05-AUG-2025
DEFINITION  DNA-binding protein RFX7 isoform X2 [Homo sapiens].
ACCESSION   XP_047288907
VERSION     XP_047288907.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432951.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1363
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1363
                     /product="DNA-binding protein RFX7 isoform X2"
                     /calculated_mol_wt=146765
     Region          8..86
                     /region_name="RFX_DNA_binding"
                     /note="RFX DNA-binding domain; pfam02257"
                     /db_xref="CDD:460512"
     Region          <161..471
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          371..>648
                     /region_name="MSCRAMM_ClfA"
                     /note="MSCRAMM family adhesin clumping factor ClfA;
                     NF033609"
                     /db_xref="CDD:468110"
     CDS             1..1363
                     /gene="RFX7"
                     /gene_synonym="MRD71; RFXDC2"
                     /coded_by="XM_047432951.1:8498..12589"
                     /db_xref="GeneID:64864"
                     /db_xref="HGNC:HGNC:25777"
                     /db_xref="MIM:612660"
ORIGIN      
        1 msssraqqmh afswirntle ehpetslpkq evydeyksyc dnlgyhplsa adfgkimknv
       61 fpnmkarrlg trgkskycys glrkkafvhm ptlpnldfhk tgdglegaep sgqlqnidee
      121 vissacrlvc ewaqkvlsqp fdtvlelarf lvkshyigtk smaaltvmaa apagmkgitq
      181 psafiptaes nsfqpqvktl pspidakqql qrkiqkkqqe qklqsplpge saakksesat
      241 sngvtnlpng npsilspqpi givvaavpsp ipvqrtrqlv tspspmsssd gkvlplnvqv
      301 vtqhmqsvkq apktpqnvpa spggdrsarh rypqilpkpa ntsaltirsp ttvlftsspi
      361 ktavvpashm sslnvvkmtt isltpsnsnt plkhsasvss atgtteesrs vpqikngsvv
      421 slqspgsrss saggtsavev kvepetssde hpvqcqensd eakapqtpsa llgqksntdg
      481 alqkpsnegv ieikatkvcd qrtkcksrcn emlpgtstgn nqstitlsva sqnltftsss
      541 sppngdsink dpklctkspr krlsstlqet qvppvkkpiv eqlsaatieg qkqgsvkkdq
      601 kvphsgkteg stagaqipsk vsvnvsshig anqplnssal visdsaleqq ttpssspdik
      661 vklegsvfll dsdsksvgsf npngwqqitk dsefisasce qqqdisvmti pehsdindle
      721 ksvwelegmp qdtysqqlhs qiqesslnqi qahssdqlpl qselkefeps vsqtnesyfp
      781 fddeltqdsi veelvlmeqq msmnnshsyg nclgmtlqsq svtpgapmss htssthfyhp
      841 ihsngtpiht ptptptptpt ptptptptse miagsqslsr espcsrlaqt tpvdsalgss
      901 rhtpigtphs ncsssvppsp vecrnpfaft pisssmayhd asivssspvk pmqrpmathp
      961 dktklewmnn gysgvgnssv sghgilpsyq elvedrfrkp hafavpgqsy qsqsrhhdth
     1021 fgrltpvspv qhqgatvnnt nkqegfavpa pldnkgtnss assnfrcrsv spavhrqrnl
     1081 sgstlypvsn iprsnvtpfg spvtpevhvf tnvhtdacan niaqrsqsvp ltvmmqtafp
     1141 nalqkqansk kitnvllskl dsdnddavrg lgmnnlpsny tarmnltqil epstvfpsan
     1201 pqnmidssts vyefqtpsyl tksnstgqin fspgdnqaqs eigeqqldfn stvkdllsgd
     1261 slqtnqqlvg qgasdltnta sdfssdirls selsgsindl ntldpnllfd pgrqqgqdde
     1321 atleelkndp lfqqicsesm nsmtssgfew ieskdhptve mlg
//
LOCUS       XP_047288908             542 aa            linear   PRI 05-AUG-2025
DEFINITION  tetratricopeptide repeat protein 23 isoform X1 [Homo sapiens].
ACCESSION   XP_047288908
VERSION     XP_047288908.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432952.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..542
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..542
                     /product="tetratricopeptide repeat protein 23 isoform X1"
                     /calculated_mol_wt=60776
     Region          100..>283
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          102..131
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          152..180
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(153,156..157,160..161,163,202,205..206,209..210,
                     212..213,244,247..248,251..252,255)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          200..230
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          243..269
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          329..401
                     /region_name="TPR_12"
                     /note="Tetratricopeptide repeat; pfam13424"
                     /db_xref="CDD:315987"
     CDS             1..542
                     /gene="TTC23"
                     /gene_synonym="HCC-8"
                     /coded_by="XM_047432952.1:510..2138"
                     /db_xref="GeneID:64927"
                     /db_xref="HGNC:HGNC:25730"
ORIGIN      
        1 mlckywhted nvyknmqesq ethisnhlde vvaavsithr kkfqnkllqt alfqpprekl
       61 hlceekaksy snsheykqav helvrcvalt ricygdshwk laeahvnlaq gylqlkglsl
      121 qakqhaekar qilansivpp ysentdvfkf sielfhtmgr allslqkfke aaenltkaer
      181 lskellqcgr iikeewieie arirlsfaqv yqgqkkskea lshyqaaley veiskgetsr
      241 ecvpilrela gveqalglhd vsinhflqah liilsrspsq veaadsahiv ahaavasgrh
      301 ehhdvaeqyf qesmahlkds egmgrtkfls iqdefchflq mtgqkerats ilresleakv
      361 eafgdfspev aetyrllgga dlaqgnhsga rkklkkaitr atfknrnwsp ssdpsehpnq
      421 rsvtrrhprs mlipsqqglr mrssfshsre tlvscsqrhf hslmiaawcs tvspdpdpli
      481 wtagqkdsgh paghghavhg pqgcfeakag iksqsgllhq hpsghpageg parhnsrlrp
      541 pp
//
LOCUS       XP_047288909             542 aa            linear   PRI 05-AUG-2025
DEFINITION  tetratricopeptide repeat protein 23 isoform X1 [Homo sapiens].
ACCESSION   XP_047288909
VERSION     XP_047288909.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432953.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..542
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..542
                     /product="tetratricopeptide repeat protein 23 isoform X1"
                     /calculated_mol_wt=60776
     Region          100..>283
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          102..131
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          152..180
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(153,156..157,160..161,163,202,205..206,209..210,
                     212..213,244,247..248,251..252,255)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          200..230
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          243..269
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          329..401
                     /region_name="TPR_12"
                     /note="Tetratricopeptide repeat; pfam13424"
                     /db_xref="CDD:315987"
     CDS             1..542
                     /gene="TTC23"
                     /gene_synonym="HCC-8"
                     /coded_by="XM_047432953.1:264..1892"
                     /db_xref="GeneID:64927"
                     /db_xref="HGNC:HGNC:25730"
ORIGIN      
        1 mlckywhted nvyknmqesq ethisnhlde vvaavsithr kkfqnkllqt alfqpprekl
       61 hlceekaksy snsheykqav helvrcvalt ricygdshwk laeahvnlaq gylqlkglsl
      121 qakqhaekar qilansivpp ysentdvfkf sielfhtmgr allslqkfke aaenltkaer
      181 lskellqcgr iikeewieie arirlsfaqv yqgqkkskea lshyqaaley veiskgetsr
      241 ecvpilrela gveqalglhd vsinhflqah liilsrspsq veaadsahiv ahaavasgrh
      301 ehhdvaeqyf qesmahlkds egmgrtkfls iqdefchflq mtgqkerats ilresleakv
      361 eafgdfspev aetyrllgga dlaqgnhsga rkklkkaitr atfknrnwsp ssdpsehpnq
      421 rsvtrrhprs mlipsqqglr mrssfshsre tlvscsqrhf hslmiaawcs tvspdpdpli
      481 wtagqkdsgh paghghavhg pqgcfeakag iksqsgllhq hpsghpageg parhnsrlrp
      541 pp
//
LOCUS       XP_011520229             539 aa            linear   PRI 05-AUG-2025
DEFINITION  tetratricopeptide repeat protein 23 isoform X2 [Homo sapiens].
ACCESSION   XP_011520229
VERSION     XP_011520229.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521927.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XP_011520229.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..539
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..539
                     /product="tetratricopeptide repeat protein 23 isoform X2"
                     /calculated_mol_wt=59666
     Region          100..>283
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          102..131
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(103,106..107,110..111,113,153,156..157,160..161,
                     163..164,202,205..206,209..210,213)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          136..181
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          201..229
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          243..269
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          329..396
                     /region_name="TPR_12"
                     /note="Tetratricopeptide repeat; pfam13424"
                     /db_xref="CDD:315987"
     CDS             1..539
                     /gene="TTC23"
                     /gene_synonym="HCC-8"
                     /coded_by="XM_011521927.3:510..2129"
                     /db_xref="GeneID:64927"
                     /db_xref="HGNC:HGNC:25730"
ORIGIN      
        1 mlckywhted nvyknmqesq ethisnhlde vvaavsithr kkfqnkllqt alfqpprekl
       61 hlceekaksy snsheykqav helvrcvalt ricygdshwk laeahvnlaq gylqlkglsl
      121 qakqhaekar qilansivpp ysentdvfkf sielfhtmgr allslqkfke aaenltkaer
      181 lskellqcgr iikeewieie arirlsfaqv yqgqkkskea lshyqaaley veiskgetsr
      241 ecvpilrela gveqalglhd vsinhflqah liilsrspsq veaadsahiv ahaavasgrh
      301 ehhdvaeqyf qesmahlkds egmgrtkfls iqdefchflq mtgqkerats ilresleakv
      361 eafgdfspev aetyrllgga dlaqgnhsga rkklkklerp qrpqgktdgp glnpgptpgs
      421 vsqgqesvvv ekdggtcsst vakgwnkvvg esrdvdkdir thgtwqpgvs pdpdpliwta
      481 gqkdsghpag hghavhgpqg cfeakagiks qsgllhqhps ghpagegpar hnsrlrppp
//
LOCUS       XP_011520241             527 aa            linear   PRI 05-AUG-2025
DEFINITION  tetratricopeptide repeat protein 23 isoform X3 [Homo sapiens].
ACCESSION   XP_011520241
VERSION     XP_011520241.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521939.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..527
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..527
                     /product="tetratricopeptide repeat protein 23 isoform X3"
                     /calculated_mol_wt=58850
     Region          85..>268
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          87..116
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          137..165
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(138,141..142,145..146,148,187,190..191,194..195,
                     197..198,229,232..233,236..237,240)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          185..215
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          228..254
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          314..386
                     /region_name="TPR_12"
                     /note="Tetratricopeptide repeat; pfam13424"
                     /db_xref="CDD:315987"
     CDS             1..527
                     /gene="TTC23"
                     /gene_synonym="HCC-8"
                     /coded_by="XM_011521939.2:308..1891"
                     /db_xref="GeneID:64927"
                     /db_xref="HGNC:HGNC:25730"
ORIGIN      
        1 mqesqethis nhldevvaav sithrkkfqn kllqtalfqp preklhlcee kaksysnshe
       61 ykqavhelvr cvaltricyg dshwklaeah vnlaqgylql kglslqakqh aekarqilan
      121 sivppysent dvfkfsielf htmgrallsl qkfkeaaenl tkaerlskel lqcgriikee
      181 wieiearirl sfaqvyqgqk kskealshyq aaleyveisk getsrecvpi lrelagveqa
      241 lglhdvsinh flqahliils rspsqveaad sahivahaav asgrhehhdv aeqyfqesma
      301 hlkdsegmgr tkflsiqdef chflqmtgqk eratsilres leakveafgd fspevaetyr
      361 llggadlaqg nhsgarkklk kaitratfkn rnwspssdps ehpnqrsvtr rhprsmlips
      421 qqglrmrssf shsretlvsc sqrhfhslmi aawcstvspd pdpliwtagq kdsghpaghg
      481 havhgpqgcf eakagiksqs gllhqhpsgh pagegparhn srlrppp
//
LOCUS       XP_011520237             527 aa            linear   PRI 05-AUG-2025
DEFINITION  tetratricopeptide repeat protein 23 isoform X3 [Homo sapiens].
ACCESSION   XP_011520237
VERSION     XP_011520237.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521935.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..527
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..527
                     /product="tetratricopeptide repeat protein 23 isoform X3"
                     /calculated_mol_wt=58850
     Region          85..>268
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          87..116
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          137..165
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(138,141..142,145..146,148,187,190..191,194..195,
                     197..198,229,232..233,236..237,240)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          185..215
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          228..254
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          314..386
                     /region_name="TPR_12"
                     /note="Tetratricopeptide repeat; pfam13424"
                     /db_xref="CDD:315987"
     CDS             1..527
                     /gene="TTC23"
                     /gene_synonym="HCC-8"
                     /coded_by="XM_011521935.2:554..2137"
                     /db_xref="GeneID:64927"
                     /db_xref="HGNC:HGNC:25730"
ORIGIN      
        1 mqesqethis nhldevvaav sithrkkfqn kllqtalfqp preklhlcee kaksysnshe
       61 ykqavhelvr cvaltricyg dshwklaeah vnlaqgylql kglslqakqh aekarqilan
      121 sivppysent dvfkfsielf htmgrallsl qkfkeaaenl tkaerlskel lqcgriikee
      181 wieiearirl sfaqvyqgqk kskealshyq aaleyveisk getsrecvpi lrelagveqa
      241 lglhdvsinh flqahliils rspsqveaad sahivahaav asgrhehhdv aeqyfqesma
      301 hlkdsegmgr tkflsiqdef chflqmtgqk eratsilres leakveafgd fspevaetyr
      361 llggadlaqg nhsgarkklk kaitratfkn rnwspssdps ehpnqrsvtr rhprsmlips
      421 qqglrmrssf shsretlvsc sqrhfhslmi aawcstvspd pdpliwtagq kdsghpaghg
      481 havhgpqgcf eakagiksqs gllhqhpsgh pagegparhn srlrppp
//
LOCUS       XP_047288910             527 aa            linear   PRI 05-AUG-2025
DEFINITION  tetratricopeptide repeat protein 23 isoform X3 [Homo sapiens].
ACCESSION   XP_047288910
VERSION     XP_047288910.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432954.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..527
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..527
                     /product="tetratricopeptide repeat protein 23 isoform X3"
                     /calculated_mol_wt=58850
     Region          85..>268
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          87..116
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          137..165
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(138,141..142,145..146,148,187,190..191,194..195,
                     197..198,229,232..233,236..237,240)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          185..215
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          228..254
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          314..386
                     /region_name="TPR_12"
                     /note="Tetratricopeptide repeat; pfam13424"
                     /db_xref="CDD:315987"
     CDS             1..527
                     /gene="TTC23"
                     /gene_synonym="HCC-8"
                     /coded_by="XM_047432954.1:392..1975"
                     /db_xref="GeneID:64927"
                     /db_xref="HGNC:HGNC:25730"
ORIGIN      
        1 mqesqethis nhldevvaav sithrkkfqn kllqtalfqp preklhlcee kaksysnshe
       61 ykqavhelvr cvaltricyg dshwklaeah vnlaqgylql kglslqakqh aekarqilan
      121 sivppysent dvfkfsielf htmgrallsl qkfkeaaenl tkaerlskel lqcgriikee
      181 wieiearirl sfaqvyqgqk kskealshyq aaleyveisk getsrecvpi lrelagveqa
      241 lglhdvsinh flqahliils rspsqveaad sahivahaav asgrhehhdv aeqyfqesma
      301 hlkdsegmgr tkflsiqdef chflqmtgqk eratsilres leakveafgd fspevaetyr
      361 llggadlaqg nhsgarkklk kaitratfkn rnwspssdps ehpnqrsvtr rhprsmlips
      421 qqglrmrssf shsretlvsc sqrhfhslmi aawcstvspd pdpliwtagq kdsghpaghg
      481 havhgpqgcf eakagiksqs gllhqhpsgh pagegparhn srlrppp
//
LOCUS       XP_011520238             527 aa            linear   PRI 05-AUG-2025
DEFINITION  tetratricopeptide repeat protein 23 isoform X3 [Homo sapiens].
ACCESSION   XP_011520238
VERSION     XP_011520238.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521936.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..527
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..527
                     /product="tetratricopeptide repeat protein 23 isoform X3"
                     /calculated_mol_wt=58850
     Region          85..>268
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          87..116
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          137..165
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(138,141..142,145..146,148,187,190..191,194..195,
                     197..198,229,232..233,236..237,240)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          185..215
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          228..254
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          314..386
                     /region_name="TPR_12"
                     /note="Tetratricopeptide repeat; pfam13424"
                     /db_xref="CDD:315987"
     CDS             1..527
                     /gene="TTC23"
                     /gene_synonym="HCC-8"
                     /coded_by="XM_011521936.2:270..1853"
                     /db_xref="GeneID:64927"
                     /db_xref="HGNC:HGNC:25730"
ORIGIN      
        1 mqesqethis nhldevvaav sithrkkfqn kllqtalfqp preklhlcee kaksysnshe
       61 ykqavhelvr cvaltricyg dshwklaeah vnlaqgylql kglslqakqh aekarqilan
      121 sivppysent dvfkfsielf htmgrallsl qkfkeaaenl tkaerlskel lqcgriikee
      181 wieiearirl sfaqvyqgqk kskealshyq aaleyveisk getsrecvpi lrelagveqa
      241 lglhdvsinh flqahliils rspsqveaad sahivahaav asgrhehhdv aeqyfqesma
      301 hlkdsegmgr tkflsiqdef chflqmtgqk eratsilres leakveafgd fspevaetyr
      361 llggadlaqg nhsgarkklk kaitratfkn rnwspssdps ehpnqrsvtr rhprsmlips
      421 qqglrmrssf shsretlvsc sqrhfhslmi aawcstvspd pdpliwtagq kdsghpaghg
      481 havhgpqgcf eakagiksqs gllhqhpsgh pagegparhn srlrppp
//
LOCUS       XP_024305796             527 aa            linear   PRI 05-AUG-2025
DEFINITION  tetratricopeptide repeat protein 23 isoform X3 [Homo sapiens].
ACCESSION   XP_024305796
VERSION     XP_024305796.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024450028.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..527
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..527
                     /product="tetratricopeptide repeat protein 23 isoform X3"
                     /calculated_mol_wt=58850
     Region          85..>268
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          87..116
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          137..165
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(138,141..142,145..146,148,187,190..191,194..195,
                     197..198,229,232..233,236..237,240)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          185..215
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          228..254
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          314..386
                     /region_name="TPR_12"
                     /note="Tetratricopeptide repeat; pfam13424"
                     /db_xref="CDD:315987"
     CDS             1..527
                     /gene="TTC23"
                     /gene_synonym="HCC-8"
                     /coded_by="XM_024450028.2:43..1626"
                     /db_xref="GeneID:64927"
                     /db_xref="HGNC:HGNC:25730"
ORIGIN      
        1 mqesqethis nhldevvaav sithrkkfqn kllqtalfqp preklhlcee kaksysnshe
       61 ykqavhelvr cvaltricyg dshwklaeah vnlaqgylql kglslqakqh aekarqilan
      121 sivppysent dvfkfsielf htmgrallsl qkfkeaaenl tkaerlskel lqcgriikee
      181 wieiearirl sfaqvyqgqk kskealshyq aaleyveisk getsrecvpi lrelagveqa
      241 lglhdvsinh flqahliils rspsqveaad sahivahaav asgrhehhdv aeqyfqesma
      301 hlkdsegmgr tkflsiqdef chflqmtgqk eratsilres leakveafgd fspevaetyr
      361 llggadlaqg nhsgarkklk kaitratfkn rnwspssdps ehpnqrsvtr rhprsmlips
      421 qqglrmrssf shsretlvsc sqrhfhslmi aawcstvspd pdpliwtagq kdsghpaghg
      481 havhgpqgcf eakagiksqs gllhqhpsgh pagegparhn srlrppp
//
LOCUS       XP_047288911             503 aa            linear   PRI 05-AUG-2025
DEFINITION  tetratricopeptide repeat protein 23 isoform X4 [Homo sapiens].
ACCESSION   XP_047288911
VERSION     XP_047288911.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432955.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..503
                     /product="tetratricopeptide repeat protein 23 isoform X4"
                     /calculated_mol_wt=56965
     Region          100..>283
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          102..131
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          152..180
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(153,156..157,160..161,163,202,205..206,209..210,
                     212..213,244,247..248,251..252,255)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          200..230
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          243..269
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          329..401
                     /region_name="TPR_12"
                     /note="Tetratricopeptide repeat; pfam13424"
                     /db_xref="CDD:315987"
     CDS             1..503
                     /gene="TTC23"
                     /gene_synonym="HCC-8"
                     /coded_by="XM_047432955.1:510..2021"
                     /db_xref="GeneID:64927"
                     /db_xref="HGNC:HGNC:25730"
ORIGIN      
        1 mlckywhted nvyknmqesq ethisnhlde vvaavsithr kkfqnkllqt alfqpprekl
       61 hlceekaksy snsheykqav helvrcvalt ricygdshwk laeahvnlaq gylqlkglsl
      121 qakqhaekar qilansivpp ysentdvfkf sielfhtmgr allslqkfke aaenltkaer
      181 lskellqcgr iikeewieie arirlsfaqv yqgqkkskea lshyqaaley veiskgetsr
      241 ecvpilrela gveqalglhd vsinhflqah liilsrspsq veaadsahiv ahaavasgrh
      301 ehhdvaeqyf qesmahlkds egmgrtkfls iqdefchflq mtgqkerats ilresleakv
      361 eafgdfspev aetyrllgga dlaqgnhsga rkklkkaitr atfknrnwsp ssdpsehpnq
      421 svsrsrpsym drrtkglwpp srpwaccprp prllrsqgrh qkpkwpsapa slrtpcwgrp
      481 gpaqqqteap tlkkprtflg tvi
//
LOCUS       XP_047288912             462 aa            linear   PRI 05-AUG-2025
DEFINITION  tetratricopeptide repeat protein 23 isoform X5 [Homo sapiens].
ACCESSION   XP_047288912
VERSION     XP_047288912.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432956.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..462
                     /product="tetratricopeptide repeat protein 23 isoform X5"
                     /calculated_mol_wt=51804
     Region          102..>229
                     /region_name="Spy"
                     /note="Predicted O-linked N-acetylglucosamine transferase,
                     SPINDLY family [Posttranslational modification, protein
                     turnover, chaperones]; COG3914"
                     /db_xref="CDD:443119"
     Region          102..131
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          152..180
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(153,156..157,160..161,163,202,205..206,209..210,
                     212..213,244,247..248,251..252,255)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          200..230
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          201..269
                     /region_name="TPR_12"
                     /note="Tetratricopeptide repeat; pfam13424"
                     /db_xref="CDD:315987"
     Region          243..269
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          329..400
                     /region_name="TPR_12"
                     /note="Tetratricopeptide repeat; pfam13424"
                     /db_xref="CDD:315987"
     CDS             1..462
                     /gene="TTC23"
                     /gene_synonym="HCC-8"
                     /coded_by="XM_047432956.1:510..1898"
                     /db_xref="GeneID:64927"
                     /db_xref="HGNC:HGNC:25730"
ORIGIN      
        1 mlckywhted nvyknmqesq ethisnhlde vvaavsithr kkfqnkllqt alfqpprekl
       61 hlceekaksy snsheykqav helvrcvalt ricygdshwk laeahvnlaq gylqlkglsl
      121 qakqhaekar qilansivpp ysentdvfkf sielfhtmgr allslqkfke aaenltkaer
      181 lskellqcgr iikeewieie arirlsfaqv yqgqkkskea lshyqaaley veiskgetsr
      241 ecvpilrela gveqalglhd vsinhflqah liilsrspsq veaadsahiv ahaavasgrh
      301 ehhdvaeqyf qesmahlkds egmgrtkfls iqdefchflq mtgqkerats ilresleakv
      361 eafgdfspev aetyrllgga dlaqgnhsga rkklkkclqi qtllygpqdk rtlatqqamg
      421 mlstapkvas kprqaskakv afctsipqdt llgkarpgtt ad
//
LOCUS       XP_016878007             447 aa            linear   PRI 05-AUG-2025
DEFINITION  tetratricopeptide repeat protein 23 isoform X6 [Homo sapiens].
ACCESSION   XP_016878007
VERSION     XP_016878007.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022518.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..447
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..447
                     /product="tetratricopeptide repeat protein 23 isoform X6"
                     /calculated_mol_wt=49878
     Region          87..>214
                     /region_name="Spy"
                     /note="Predicted O-linked N-acetylglucosamine transferase,
                     SPINDLY family [Posttranslational modification, protein
                     turnover, chaperones]; COG3914"
                     /db_xref="CDD:443119"
     Region          87..116
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          137..165
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(138,141..142,145..146,148,187,190..191,194..195,
                     197..198,229,232..233,236..237,240)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          185..215
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          186..254
                     /region_name="TPR_12"
                     /note="Tetratricopeptide repeat; pfam13424"
                     /db_xref="CDD:315987"
     Region          228..254
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          314..385
                     /region_name="TPR_12"
                     /note="Tetratricopeptide repeat; pfam13424"
                     /db_xref="CDD:315987"
     CDS             1..447
                     /gene="TTC23"
                     /gene_synonym="HCC-8"
                     /coded_by="XM_017022518.2:308..1651"
                     /db_xref="GeneID:64927"
                     /db_xref="HGNC:HGNC:25730"
ORIGIN      
        1 mqesqethis nhldevvaav sithrkkfqn kllqtalfqp preklhlcee kaksysnshe
       61 ykqavhelvr cvaltricyg dshwklaeah vnlaqgylql kglslqakqh aekarqilan
      121 sivppysent dvfkfsielf htmgrallsl qkfkeaaenl tkaerlskel lqcgriikee
      181 wieiearirl sfaqvyqgqk kskealshyq aaleyveisk getsrecvpi lrelagveqa
      241 lglhdvsinh flqahliils rspsqveaad sahivahaav asgrhehhdv aeqyfqesma
      301 hlkdsegmgr tkflsiqdef chflqmtgqk eratsilres leakveafgd fspevaetyr
      361 llggadlaqg nhsgarkklk kclqiqtlly gpqdkrtlat qqamgmlsta pkvaskprqa
      421 skakvafcts ipqdtllgka rpgttad
//
LOCUS       XP_047288913             434 aa            linear   PRI 05-AUG-2025
DEFINITION  tetratricopeptide repeat protein 23 isoform X7 [Homo sapiens].
ACCESSION   XP_047288913
VERSION     XP_047288913.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432957.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..434
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..434
                     /product="tetratricopeptide repeat protein 23 isoform X7"
                     /calculated_mol_wt=48742
     Region          102..>229
                     /region_name="Spy"
                     /note="Predicted O-linked N-acetylglucosamine transferase,
                     SPINDLY family [Posttranslational modification, protein
                     turnover, chaperones]; COG3914"
                     /db_xref="CDD:443119"
     Region          102..131
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          152..180
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(153,156..157,160..161,163,202,205..206,209..210,
                     212..213,244,247..248,251..252,255)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          200..230
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          201..269
                     /region_name="TPR_12"
                     /note="Tetratricopeptide repeat; pfam13424"
                     /db_xref="CDD:315987"
     Region          243..269
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          329..396
                     /region_name="TPR_12"
                     /note="Tetratricopeptide repeat; pfam13424"
                     /db_xref="CDD:315987"
     CDS             1..434
                     /gene="TTC23"
                     /gene_synonym="HCC-8"
                     /coded_by="XM_047432957.1:510..1814"
                     /db_xref="GeneID:64927"
                     /db_xref="HGNC:HGNC:25730"
ORIGIN      
        1 mlckywhted nvyknmqesq ethisnhlde vvaavsithr kkfqnkllqt alfqpprekl
       61 hlceekaksy snsheykqav helvrcvalt ricygdshwk laeahvnlaq gylqlkglsl
      121 qakqhaekar qilansivpp ysentdvfkf sielfhtmgr allslqkfke aaenltkaer
      181 lskellqcgr iikeewieie arirlsfaqv yqgqkkskea lshyqaaley veiskgetsr
      241 ecvpilrela gveqalglhd vsinhflqah liilsrspsq veaadsahiv ahaavasgrh
      301 ehhdvaeqyf qesmahlkds egmgrtkfls iqdefchflq mtgqkerats ilresleakv
      361 eafgdfspev aetyrllgga dlaqgnhsga rkklkklerp qrpqgktdgp glnpgptpgs
      421 vsqgqesgyn kghi
//
LOCUS       XP_047288914             432 aa            linear   PRI 05-AUG-2025
DEFINITION  tetratricopeptide repeat protein 23 isoform X8 [Homo sapiens].
ACCESSION   XP_047288914
VERSION     XP_047288914.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432958.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..432
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..432
                     /product="tetratricopeptide repeat protein 23 isoform X8"
                     /calculated_mol_wt=48484
     Region          102..>229
                     /region_name="Spy"
                     /note="Predicted O-linked N-acetylglucosamine transferase,
                     SPINDLY family [Posttranslational modification, protein
                     turnover, chaperones]; COG3914"
                     /db_xref="CDD:443119"
     Region          102..131
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          152..180
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(153,156..157,160..161,163,202,205..206,209..210,
                     212..213,244,247..248,251..252,255)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          200..230
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          201..269
                     /region_name="TPR_12"
                     /note="Tetratricopeptide repeat; pfam13424"
                     /db_xref="CDD:315987"
     Region          243..269
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          329..396
                     /region_name="TPR_12"
                     /note="Tetratricopeptide repeat; pfam13424"
                     /db_xref="CDD:315987"
     CDS             1..432
                     /gene="TTC23"
                     /gene_synonym="HCC-8"
                     /coded_by="XM_047432958.1:510..1808"
                     /db_xref="GeneID:64927"
                     /db_xref="HGNC:HGNC:25730"
ORIGIN      
        1 mlckywhted nvyknmqesq ethisnhlde vvaavsithr kkfqnkllqt alfqpprekl
       61 hlceekaksy snsheykqav helvrcvalt ricygdshwk laeahvnlaq gylqlkglsl
      121 qakqhaekar qilansivpp ysentdvfkf sielfhtmgr allslqkfke aaenltkaer
      181 lskellqcgr iikeewieie arirlsfaqv yqgqkkskea lshyqaaley veiskgetsr
      241 ecvpilrela gveqalglhd vsinhflqah liilsrspsq veaadsahiv ahaavasgrh
      301 ehhdvaeqyf qesmahlkds egmgrtkfls iqdefchflq mtgqkerats ilresleakv
      361 eafgdfspev aetyrllgga dlaqgnhsga rkklkklerp qrpqgktdgp glnpgptpgs
      421 vsqgqesvlg ie
//
LOCUS       XP_047288915             417 aa            linear   PRI 05-AUG-2025
DEFINITION  tetratricopeptide repeat protein 23 isoform X9 [Homo sapiens].
ACCESSION   XP_047288915
VERSION     XP_047288915.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432959.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..417
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..417
                     /product="tetratricopeptide repeat protein 23 isoform X9"
                     /calculated_mol_wt=46558
     Region          87..>214
                     /region_name="Spy"
                     /note="Predicted O-linked N-acetylglucosamine transferase,
                     SPINDLY family [Posttranslational modification, protein
                     turnover, chaperones]; COG3914"
                     /db_xref="CDD:443119"
     Region          87..116
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          137..165
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(138,141..142,145..146,148,187,190..191,194..195,
                     197..198,229,232..233,236..237,240)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          185..215
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          186..254
                     /region_name="TPR_12"
                     /note="Tetratricopeptide repeat; pfam13424"
                     /db_xref="CDD:315987"
     Region          228..254
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          314..381
                     /region_name="TPR_12"
                     /note="Tetratricopeptide repeat; pfam13424"
                     /db_xref="CDD:315987"
     CDS             1..417
                     /gene="TTC23"
                     /gene_synonym="HCC-8"
                     /coded_by="XM_047432959.1:308..1561"
                     /db_xref="GeneID:64927"
                     /db_xref="HGNC:HGNC:25730"
ORIGIN      
        1 mqesqethis nhldevvaav sithrkkfqn kllqtalfqp preklhlcee kaksysnshe
       61 ykqavhelvr cvaltricyg dshwklaeah vnlaqgylql kglslqakqh aekarqilan
      121 sivppysent dvfkfsielf htmgrallsl qkfkeaaenl tkaerlskel lqcgriikee
      181 wieiearirl sfaqvyqgqk kskealshyq aaleyveisk getsrecvpi lrelagveqa
      241 lglhdvsinh flqahliils rspsqveaad sahivahaav asgrhehhdv aeqyfqesma
      301 hlkdsegmgr tkflsiqdef chflqmtgqk eratsilres leakveafgd fspevaetyr
      361 llggadlaqg nhsgarkklk klerpqrpqg ktdgpglnpg ptpgsvsqgq esvlgie
//
LOCUS       XP_047288916             408 aa            linear   PRI 05-AUG-2025
DEFINITION  tetratricopeptide repeat protein 23 isoform X10 [Homo sapiens].
ACCESSION   XP_047288916
VERSION     XP_047288916.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432960.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..408
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..408
                     /product="tetratricopeptide repeat protein 23 isoform X10"
                     /calculated_mol_wt=46034
     Region          102..>229
                     /region_name="Spy"
                     /note="Predicted O-linked N-acetylglucosamine transferase,
                     SPINDLY family [Posttranslational modification, protein
                     turnover, chaperones]; COG3914"
                     /db_xref="CDD:443119"
     Region          102..131
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          152..180
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(153,156..157,160..161,163,202,205..206,209..210,
                     212..213,244,247..248,251..252,255)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          200..230
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          201..269
                     /region_name="TPR_12"
                     /note="Tetratricopeptide repeat; pfam13424"
                     /db_xref="CDD:315987"
     Region          243..269
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          329..396
                     /region_name="TPR_12"
                     /note="Tetratricopeptide repeat; pfam13424"
                     /db_xref="CDD:315987"
     CDS             1..408
                     /gene="TTC23"
                     /gene_synonym="HCC-8"
                     /coded_by="XM_047432960.1:510..1736"
                     /db_xref="GeneID:64927"
                     /db_xref="HGNC:HGNC:25730"
ORIGIN      
        1 mlckywhted nvyknmqesq ethisnhlde vvaavsithr kkfqnkllqt alfqpprekl
       61 hlceekaksy snsheykqav helvrcvalt ricygdshwk laeahvnlaq gylqlkglsl
      121 qakqhaekar qilansivpp ysentdvfkf sielfhtmgr allslqkfke aaenltkaer
      181 lskellqcgr iikeewieie arirlsfaqv yqgqkkskea lshyqaaley veiskgetsr
      241 ecvpilrela gveqalglhd vsinhflqah liilsrspsq veaadsahiv ahaavasgrh
      301 ehhdvaeqyf qesmahlkds egmgrtkfls iqdefchflq mtgqkerats ilresleakv
      361 eafgdfspev aetyrllgga dlaqgnhsga rkklkkgdls fllsatlp
//
LOCUS       XP_047288917             408 aa            linear   PRI 05-AUG-2025
DEFINITION  tetratricopeptide repeat protein 23 isoform X11 [Homo sapiens].
ACCESSION   XP_047288917
VERSION     XP_047288917.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432961.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..408
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..408
                     /product="tetratricopeptide repeat protein 23 isoform X11"
                     /calculated_mol_wt=46156
     Region          102..>229
                     /region_name="Spy"
                     /note="Predicted O-linked N-acetylglucosamine transferase,
                     SPINDLY family [Posttranslational modification, protein
                     turnover, chaperones]; COG3914"
                     /db_xref="CDD:443119"
     Region          102..131
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          152..180
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(153,156..157,160..161,163,202,205..206,209..210,
                     212..213,244,247..248,251..252,255)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          200..230
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          201..269
                     /region_name="TPR_12"
                     /note="Tetratricopeptide repeat; pfam13424"
                     /db_xref="CDD:315987"
     Region          243..269
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          329..391
                     /region_name="TPR_12"
                     /note="Tetratricopeptide repeat; pfam13424"
                     /db_xref="CDD:315987"
     CDS             1..408
                     /gene="TTC23"
                     /gene_synonym="HCC-8"
                     /coded_by="XM_047432961.1:510..1736"
                     /db_xref="GeneID:64927"
                     /db_xref="HGNC:HGNC:25730"
ORIGIN      
        1 mlckywhted nvyknmqesq ethisnhlde vvaavsithr kkfqnkllqt alfqpprekl
       61 hlceekaksy snsheykqav helvrcvalt ricygdshwk laeahvnlaq gylqlkglsl
      121 qakqhaekar qilansivpp ysentdvfkf sielfhtmgr allslqkfke aaenltkaer
      181 lskellqcgr iikeewieie arirlsfaqv yqgqkkskea lshyqaaley veiskgetsr
      241 ecvpilrela gveqalglhd vsinhflqah liilsrspsq veaadsahiv ahaavasgrh
      301 ehhdvaeqyf qesmahlkds egmgrtkfls iqdefchflq mtgqkerats ilresleakv
      361 eafgdfspev aetyrllgga dlaqgnhsga rkklkknlkr klvlegsv
//
LOCUS       XP_047288918             385 aa            linear   PRI 05-AUG-2025
DEFINITION  tetratricopeptide repeat protein 23 isoform X12 [Homo sapiens].
ACCESSION   XP_047288918
VERSION     XP_047288918.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432962.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..385
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..385
                     /product="tetratricopeptide repeat protein 23 isoform X12"
                     /calculated_mol_wt=42562
     Region          <1..202
                     /region_name="LapB"
                     /note="Lipopolysaccharide biosynthesis regulator
                     YciM/LapB, contains six TPR domains and a C-terminal
                     metal-binding domain [Cell wall/membrane/envelope
                     biogenesis]; COG2956"
                     /db_xref="CDD:442196"
     Site            order(3..4,6,45,48..49,52..53,55..56,87,90..91,94..95,98)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          43..73
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          44..112
                     /region_name="TPR_12"
                     /note="Tetratricopeptide repeat; pfam13424"
                     /db_xref="CDD:315987"
     Region          86..112
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          172..244
                     /region_name="TPR_12"
                     /note="Tetratricopeptide repeat; pfam13424"
                     /db_xref="CDD:315987"
     CDS             1..385
                     /gene="TTC23"
                     /gene_synonym="HCC-8"
                     /coded_by="XM_047432962.1:484..1641"
                     /db_xref="GeneID:64927"
                     /db_xref="HGNC:HGNC:25730"
ORIGIN      
        1 mgrallslqk fkeaaenltk aerlskellq cgriikeewi eiearirlsf aqvyqgqkks
       61 kealshyqaa leyveiskge tsrecvpilr elagveqalg lhdvsinhfl qahliilsrs
      121 psqveaadsa hivahaavas grhehhdvae qyfqesmahl kdsegmgrtk flsiqdefch
      181 flqmtgqker atsilresle akveafgdfs pevaetyrll ggadlaqgnh sgarkklkka
      241 itratfknrn wspssdpseh pnqrsvtrrh prsmlipsqq glrmrssfsh sretlvscsq
      301 rhfhslmiaa wcstvspdpd pliwtagqkd sghpaghgha vhgpqgcfea kagiksqsgl
      361 lhqhpsghpa gegparhnsr lrppp
//
LOCUS       XP_006720714             619 aa            linear   PRI 05-AUG-2025
DEFINITION  golgin subfamily A member 8J isoform X1 [Homo sapiens].
ACCESSION   XP_006720714
VERSION     XP_006720714.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720651.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..619
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..619
                     /product="golgin subfamily A member 8J isoform X1"
                     /calculated_mol_wt=70209
     Region          73..>277
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     Region          213..>446
                     /region_name="GOLGA2L5"
                     /note="Putative golgin subfamily A member 2-like protein
                     5; pfam15070"
                     /db_xref="CDD:464485"
     Region          580..619
                     /region_name="GM130_C"
                     /note="GM130 C-terminal binding motif; pfam19046"
                     /db_xref="CDD:465957"
     CDS             1..619
                     /gene="GOLGA8J"
                     /coded_by="XM_006720651.4:81..1940"
                     /db_xref="GeneID:653073"
                     /db_xref="HGNC:HGNC:38650"
ORIGIN      
        1 mltlkeywqk nsprvpagan rnrktngsip ekatsggcqp prdsatgfhr egptssatlk
       61 dlespcqera vvldsrsvei sqlkntiksl kqqkkqvehq leeekkannk kqkakrvlev
      121 qiqtlniqke elntdlyhmk rslryfeeks kdlavrlqhs lqrkgelesv lsnvmatqkk
      181 kanqlssrsk artewkleqs mreeallkvq ltqfkesfqq vqlerdeyse hlkgerarwq
      241 qrmrkmsqei ctlkkekqqd mrrveklers lsklknqmae plppeppavp sevelqhlrk
      301 elervagelq aqvknnqris llnqrqeeri reqeerlrkq eeriqeqhks lqqlakpqsv
      361 fkepnnenkn alqleqqvke lqeklgeehl eaasqqnqql taqlslmalp geghggehld
      421 segeeaprpm psvpedpesr eamssfmdhl eekadlselv kkkelcfihh wrerchqkth
      481 hllsepggra kdaalggghh qagaqggdeg eaagaaadgi aaysnynngh rkflaaahns
      541 adepgpgapa pqelgaadkh ghlcevslts saqgearedp lldkptaqpi vqdhqehpgl
      601 gsnccvpflc wawlprrrr
//
LOCUS       XP_047288919             551 aa            linear   PRI 05-AUG-2025
DEFINITION  golgin subfamily A member 8J isoform X2 [Homo sapiens].
ACCESSION   XP_047288919
VERSION     XP_047288919.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432963.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..551
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..551
                     /product="golgin subfamily A member 8J isoform X2"
                     /calculated_mol_wt=62426
     Region          145..>378
                     /region_name="GOLGA2L5"
                     /note="Putative golgin subfamily A member 2-like protein
                     5; pfam15070"
                     /db_xref="CDD:464485"
     Region          512..551
                     /region_name="GM130_C"
                     /note="GM130 C-terminal binding motif; pfam19046"
                     /db_xref="CDD:465957"
     CDS             1..551
                     /gene="GOLGA8J"
                     /coded_by="XM_047432963.1:895..2550"
                     /db_xref="GeneID:653073"
                     /db_xref="HGNC:HGNC:38650"
ORIGIN      
        1 mggpvlghww hsggmslavp slpppgkssv flflqekkan nkkqkakrvl evqiqtlniq
       61 keelntdlyh mkrslryfee kskdlavrlq hslqrkgele svlsnvmatq kkkanqlssr
      121 skartewkle qsmreeallk vqltqfkesf qqvqlerdey sehlkgerar wqqrmrkmsq
      181 eictlkkekq qdmrrvekle rslsklknqm aeplppeppa vpsevelqhl rkelervage
      241 lqaqvknnqr isllnqrqee rireqeerlr kqeeriqeqh kslqqlakpq svfkepnnen
      301 knalqleqqv kelqeklgee hleaasqqnq qltaqlslma lpgeghggeh ldsegeeapr
      361 pmpsvpedpe sreamssfmd hleekadlse lvkkkelcfi hhwrerchqk thhllsepgg
      421 rakdaalggg hhqagaqggd egeaagaaad giaaysnynn ghrkflaaah nsadepgpga
      481 papqelgaad khghlcevsl tssaqgeare dplldkptaq pivqdhqehp glgsnccvpf
      541 lcwawlprrr r
//
LOCUS       XP_011520252             449 aa            linear   PRI 05-AUG-2025
DEFINITION  golgin subfamily A member 8J isoform X3 [Homo sapiens].
ACCESSION   XP_011520252
VERSION     XP_011520252.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521950.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..449
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..449
                     /product="golgin subfamily A member 8J isoform X3"
                     /calculated_mol_wt=52500
     Region          <80..>325
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          226..>449
                     /region_name="GOLGA2L5"
                     /note="Putative golgin subfamily A member 2-like protein
                     5; pfam15070"
                     /db_xref="CDD:464485"
     CDS             1..449
                     /gene="GOLGA8J"
                     /coded_by="XM_011521950.3:99..1448"
                     /db_xref="GeneID:653073"
                     /db_xref="HGNC:HGNC:38650"
ORIGIN      
        1 maeetqhnkl aaakkklkey wqknsprvpa ganrnrktng sipekatsgg cqpprdsatg
       61 fhregptssa tlkdlespcq eravvldsrs veisqlknti kslkqqkkqv ehqleeekka
      121 nnkkqkakrv levqiqtlni qkeelntdly hmkrslryfe ekskdlavrl qhslqrkgel
      181 esvlsnvmat qkkkanqlss rskartewkl eqsmreeall kvqltqfkes fqqvqlerde
      241 ysehlkgera rwqqrmrkms qeictlkkek qqdmrrvekl erslsklknq maeplppepp
      301 avpsevelqh lrkelervag elqaqvknnq risllnqrqe erireqeerl rkqeeriqeq
      361 hkslqqlakp qsvfkepnne nknalqleqq vkelqeklge velksqeaqs lqqqpdhylg
      421 hlqqyvatyq qqvaayqqlt cekealyrq
//
LOCUS       XP_024305800             618 aa            linear   PRI 05-AUG-2025
DEFINITION  golgin subfamily A member 8T isoform X1 [Homo sapiens].
ACCESSION   XP_024305800
VERSION     XP_024305800.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024450032.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..618
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..618
                     /product="golgin subfamily A member 8T isoform X1"
                     /calculated_mol_wt=70079
     Region          73..>277
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     Region          213..>497
                     /region_name="GOLGA2L5"
                     /note="Putative golgin subfamily A member 2-like protein
                     5; pfam15070"
                     /db_xref="CDD:464485"
     Region          579..618
                     /region_name="GM130_C"
                     /note="GM130 C-terminal binding motif; pfam19046"
                     /db_xref="CDD:465957"
     CDS             1..618
                     /gene="GOLGA8T"
                     /coded_by="XM_024450032.2:158..2014"
                     /db_xref="GeneID:653075"
                     /db_xref="HGNC:HGNC:44410"
ORIGIN      
        1 mltlkeywqk nsprvpagan rnrktngsip ekatsggcqp prdsatgfhr egptssatlk
       61 dlespcqera vvldsrsvei sqlkntiksl kqqkkqvehq leeekkannk kqkakrvlev
      121 qiqtlniqke elntdlyhmk rslryfeeks kdlavrlqhs lqrkgelesv lsnvmatqkk
      181 kanqlssrsk artewkleqs mreetllkvq ltqlkesfqq vqlerdeyse hlkgerarwq
      241 qrmrkmsqei ctlkkekqqd mrrveelers lsklknqmae plppeppavp sevelqhlrk
      301 elervagelq aqvkknqris llnqrqeeri qeqeerlrkq eeriqeqhks lqqlakpqsv
      361 feepnnenkn alqleqqvke lqeklgeehl eaasqqnqql taqlslmalp geghggehld
      421 segeeapqpm psvpedlesr eamssfmdhl kekadlselv kkelcfihhw rdrrhqkthh
      481 llsepggcak daalggghhq agaqggdege aagaaadgia aysnynnghr kflaaahnpa
      541 depgpgapap qelgaadkhg dlrevsltss aqgearedpl ldkptaqpiv qdhqehpglg
      601 snccvpflcw awlprrrr
//
LOCUS       XP_047288921             693 aa            linear   PRI 05-AUG-2025
DEFINITION  golgin subfamily A member 6D isoform X1 [Homo sapiens].
ACCESSION   XP_047288921
VERSION     XP_047288921.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432965.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..693
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..693
                     /product="golgin subfamily A member 6D isoform X1"
                     /calculated_mol_wt=79765
     Region          <68..284
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          217..628
                     /region_name="GOLGA2L5"
                     /note="Putative golgin subfamily A member 2-like protein
                     5; pfam15070"
                     /db_xref="CDD:464485"
     Region          673..>693
                     /region_name="GM130_C"
                     /note="GM130 C-terminal binding motif; pfam19046"
                     /db_xref="CDD:465957"
     CDS             1..693
                     /gene="GOLGA6D"
                     /coded_by="XM_047432965.1:991..3072"
                     /db_xref="GeneID:653643"
                     /db_xref="HGNC:HGNC:32204"
ORIGIN      
        1 mwpqpylpph pmmleesrqn klaaakkklk eyqqrkspgi pagaktkkkk tdsspettts
       61 ggghspgdsq yqelavales ssvtinqlne nieslkqqkk qvehqleeak ktnneihkaq
      121 meqletinil tlekadlktt lyhtkraarh feeeskdlag rlqyslqhiq eleralcavs
      181 tqqqeedrss screavlqrr lqqtikeral lnahvtqvte slkqvqlerd eyakhikger
      241 arwqermwkm sveartlkee kkrdihriqe lerslselkn qmaeppslap pavtsvveql
      301 qdeakhlrqe veglegklqs qvennqalsl lskeqkqrlq eqeemlreqe aqrvreqerl
      361 ceqnerlreq qktlqeqger lrkqeqrlrk qeerlrkeee rlqkqekrlw dqeerlwkke
      421 erlqkqeerl alsqnhkldk qlaepqcsfe dlnnekksal qleqqvkelq ekldeehlea
      481 asqrnqqlet qlslvalpge gdggqhldse eeeaprptpn ipedlesrea tssfmdlpke
      541 kadgteqver relgfvqpsg vtdgmresft vyesqgavpn trhqemedvi rlaqkeeemk
      601 vkllelqelv lplvgnhegh gkfliaaqnp adeptpgapa pqelgaageq dvfyevsldn
      661 nvepapgvar egsphnnptv qqivqlspvm qdt
//
LOCUS       XP_005268341             678 aa            linear   PRI 05-AUG-2025
DEFINITION  golgin subfamily A member 8M isoform X1 [Homo sapiens].
ACCESSION   XP_005268341
VERSION     XP_005268341.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005268284.6
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..678
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..678
                     /product="golgin subfamily A member 8M isoform X1"
                     /calculated_mol_wt=76520
     Region          132..>337
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     Region          272..>525
                     /region_name="GOLGA2L5"
                     /note="Putative golgin subfamily A member 2-like protein
                     5; pfam15070"
                     /db_xref="CDD:464485"
     Region          639..678
                     /region_name="GM130_C"
                     /note="GM130 C-terminal binding motif; pfam19046"
                     /db_xref="CDD:465957"
     CDS             1..678
                     /gene="GOLGA8M"
                     /coded_by="XM_005268284.6:1672..3708"
                     /db_xref="GeneID:653720"
                     /db_xref="HGNC:HGNC:44404"
ORIGIN      
        1 mtqspkrshl vsgssghrtn fqlegewrlw dlgargsrlp hsltdvdggk slhfphelkt
       61 ltlkeywqkn sprvpaganr nrktngsipq tatsggcqpp gdsatgfhre gptssatlkd
      121 lespcqerav vldsrsveis qlkntikslk qqkkqvehql eeekkannkk qkakrvlevq
      181 lqtlniqkee lntdlyhmkr slryfeeksk dlavrlqhsl qrkgelesvl sdvmatqkkk
      241 anqlsspska gtewkleqsm reeallkvql tqlkesfqqv qlerdeyseh lkgerarwqq
      301 rmrkmsqeic tlkkekqqdm rrveklersl sklknqmaep lppeppavps evelqhlrke
      361 lervagelqa qvknnqrisl lnqrqeerir eqeerlrkqe eriqeqhksl qqlakpqsvf
      421 eepnnenkst lqleqqvkel qeklgeehle aasqqnqqlt aqlslmalpg eghggehlds
      481 egeeapqpmp svpedpesre amssfmdhle ekadlselvk kqelrfiqyw qerchqkihh
      541 llsepggrak daalggghhq agaqggdege aagaaadgia aysnynnghr kflaaahnsa
      601 depgpgapap qelgaadkhg dlcevsltss aqgearedpl ldkptaqpiv qdhqehpglg
      661 snccvpffcw awlprrrr
//
LOCUS       XP_005268342             655 aa            linear   PRI 05-AUG-2025
DEFINITION  golgin subfamily A member 8M isoform X2 [Homo sapiens].
ACCESSION   XP_005268342
VERSION     XP_005268342.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005268285.6
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..655
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..655
                     /product="golgin subfamily A member 8M isoform X2"
                     /calculated_mol_wt=73838
     Region          132..>337
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     Region          272..>502
                     /region_name="GOLGA2L5"
                     /note="Putative golgin subfamily A member 2-like protein
                     5; pfam15070"
                     /db_xref="CDD:464485"
     Region          616..655
                     /region_name="GM130_C"
                     /note="GM130 C-terminal binding motif; pfam19046"
                     /db_xref="CDD:465957"
     CDS             1..655
                     /gene="GOLGA8M"
                     /coded_by="XM_005268285.6:1672..3639"
                     /db_xref="GeneID:653720"
                     /db_xref="HGNC:HGNC:44404"
ORIGIN      
        1 mtqspkrshl vsgssghrtn fqlegewrlw dlgargsrlp hsltdvdggk slhfphelkt
       61 ltlkeywqkn sprvpaganr nrktngsipq tatsggcqpp gdsatgfhre gptssatlkd
      121 lespcqerav vldsrsveis qlkntikslk qqkkqvehql eeekkannkk qkakrvlevq
      181 lqtlniqkee lntdlyhmkr slryfeeksk dlavrlqhsl qrkgelesvl sdvmatqkkk
      241 anqlsspska gtewkleqsm reeallkvql tqlkesfqqv qlerdeyseh lkgerarwqq
      301 rmrkmsqeic tlkkekqqdm rrveklersl sklknqmaep lppeppavps evelqhlrke
      361 lervagelqa qvknnqrisl lnqrqeerir eqeerlrkqe eriqeqhksl qqlakpqsvf
      421 eepehleaas qqnqqltaql slmalpgegh ggehldsege eapqpmpsvp edpesreams
      481 sfmdhleeka dlselvkkqe lrfiqywqer chqkihhlls epggrakdaa lggghhqaga
      541 qggdegeaag aaadgiaays nynnghrkfl aaahnsadep gpgapapqel gaadkhgdlc
      601 evsltssaqg earedplldk ptaqpivqdh qehpglgsnc cvpffcwawl prrrr
//
LOCUS       XP_006720717             619 aa            linear   PRI 05-AUG-2025
DEFINITION  golgin subfamily A member 8M isoform X3 [Homo sapiens].
ACCESSION   XP_006720717
VERSION     XP_006720717.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720654.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..619
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..619
                     /product="golgin subfamily A member 8M isoform X3"
                     /calculated_mol_wt=69933
     Region          73..>278
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     Region          213..>466
                     /region_name="GOLGA2L5"
                     /note="Putative golgin subfamily A member 2-like protein
                     5; pfam15070"
                     /db_xref="CDD:464485"
     Region          580..619
                     /region_name="GM130_C"
                     /note="GM130 C-terminal binding motif; pfam19046"
                     /db_xref="CDD:465957"
     CDS             1..619
                     /gene="GOLGA8M"
                     /coded_by="XM_006720654.4:85..1944"
                     /db_xref="GeneID:653720"
                     /db_xref="HGNC:HGNC:44404"
ORIGIN      
        1 mltlkeywqk nsprvpagan rnrktngsip qtatsggcqp pgdsatgfhr egptssatlk
       61 dlespcqera vvldsrsvei sqlkntiksl kqqkkqvehq leeekkannk kqkakrvlev
      121 qlqtlniqke elntdlyhmk rslryfeeks kdlavrlqhs lqrkgelesv lsdvmatqkk
      181 kanqlsspsk agtewkleqs mreeallkvq ltqlkesfqq vqlerdeyse hlkgerarwq
      241 qrmrkmsqei ctlkkekqqd mrrveklers lsklknqmae plppeppavp sevelqhlrk
      301 elervagelq aqvknnqris llnqrqeeri reqeerlrkq eeriqeqhks lqqlakpqsv
      361 feepnnenks tlqleqqvke lqeklgeehl eaasqqnqql taqlslmalp geghggehld
      421 segeeapqpm psvpedpesr eamssfmdhl eekadlselv kkqelrfiqy wqerchqkih
      481 hllsepggra kdaalggghh qagaqggdeg eaagaaadgi aaysnynngh rkflaaahns
      541 adepgpgapa pqelgaadkh gdlcevslts saqgearedp lldkptaqpi vqdhqehpgl
      601 gsnccvpffc wawlprrrr
//
LOCUS       XP_011520253             481 aa            linear   PRI 05-AUG-2025
DEFINITION  golgin subfamily A member 8M isoform X4 [Homo sapiens].
ACCESSION   XP_011520253
VERSION     XP_011520253.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521951.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..481
                     /product="golgin subfamily A member 8M isoform X4"
                     /calculated_mol_wt=54443
     Region          75..>328
                     /region_name="GOLGA2L5"
                     /note="Putative golgin subfamily A member 2-like protein
                     5; pfam15070"
                     /db_xref="CDD:464485"
     Region          442..481
                     /region_name="GM130_C"
                     /note="GM130 C-terminal binding motif; pfam19046"
                     /db_xref="CDD:465957"
     CDS             1..481
                     /gene="GOLGA8M"
                     /coded_by="XM_011521951.4:685..2130"
                     /db_xref="GeneID:653720"
                     /db_xref="HGNC:HGNC:44404"
ORIGIN      
        1 mkrslryfee kskdlavrlq hslqrkgele svlsdvmatq kkkanqlssp skagtewkle
       61 qsmreeallk vqltqlkesf qqvqlerdey sehlkgerar wqqrmrkmsq eictlkkekq
      121 qdmrrvekle rslsklknqm aeplppeppa vpsevelqhl rkelervage lqaqvknnqr
      181 isllnqrqee rireqeerlr kqeeriqeqh kslqqlakpq svfeepnnen kstlqleqqv
      241 kelqeklgee hleaasqqnq qltaqlslma lpgeghggeh ldsegeeapq pmpsvpedpe
      301 sreamssfmd hleekadlse lvkkqelrfi qywqerchqk ihhllsepgg rakdaalggg
      361 hhqagaqggd egeaagaaad giaaysnynn ghrkflaaah nsadepgpga papqelgaad
      421 khgdlcevsl tssaqgeare dplldkptaq pivqdhqehp glgsnccvpf fcwawlprrr
      481 r
//
LOCUS       XP_011520254             560 aa            linear   PRI 05-AUG-2025
DEFINITION  golgin subfamily A member 8M isoform X5 [Homo sapiens].
ACCESSION   XP_011520254
VERSION     XP_011520254.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521952.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..560
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..560
                     /product="golgin subfamily A member 8M isoform X5"
                     /calculated_mol_wt=63969
     Region          132..>337
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     Region          272..>528
                     /region_name="GOLGA2L5"
                     /note="Putative golgin subfamily A member 2-like protein
                     5; pfam15070"
                     /db_xref="CDD:464485"
     CDS             1..560
                     /gene="GOLGA8M"
                     /coded_by="XM_011521952.4:1672..3354"
                     /db_xref="GeneID:653720"
                     /db_xref="HGNC:HGNC:44404"
ORIGIN      
        1 mtqspkrshl vsgssghrtn fqlegewrlw dlgargsrlp hsltdvdggk slhfphelkt
       61 ltlkeywqkn sprvpaganr nrktngsipq tatsggcqpp gdsatgfhre gptssatlkd
      121 lespcqerav vldsrsveis qlkntikslk qqkkqvehql eeekkannkk qkakrvlevq
      181 lqtlniqkee lntdlyhmkr slryfeeksk dlavrlqhsl qrkgelesvl sdvmatqkkk
      241 anqlsspska gtewkleqsm reeallkvql tqlkesfqqv qlerdeyseh lkgerarwqq
      301 rmrkmsqeic tlkkekqqdm rrveklersl sklknqmaep lppeppavps evelqhlrke
      361 lervagelqa qvknnqrisl lnqrqeerir eqeerlrkqe eriqeqhksl qqlakpqsvf
      421 eepnnenkst lqleqqvkel qeklgeehle aasqqnqqlt aqlslmalpg eghggehlds
      481 egeeapqpmp svpedpesre amvaflksag asaqekqaql qeqvkeqrva asawltrwpr
      541 prrsqrqpea lqpqglgasl
//
LOCUS       XP_011520255             495 aa            linear   PRI 05-AUG-2025
DEFINITION  golgin subfamily A member 8M isoform X6 [Homo sapiens].
ACCESSION   XP_011520255
VERSION     XP_011520255.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521953.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..495
                     /product="golgin subfamily A member 8M isoform X6"
                     /calculated_mol_wt=57262
     Region          132..>337
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     Region          272..>495
                     /region_name="GOLGA2L5"
                     /note="Putative golgin subfamily A member 2-like protein
                     5; pfam15070"
                     /db_xref="CDD:464485"
     CDS             1..495
                     /gene="GOLGA8M"
                     /coded_by="XM_011521953.4:1672..3159"
                     /db_xref="GeneID:653720"
                     /db_xref="HGNC:HGNC:44404"
ORIGIN      
        1 mtqspkrshl vsgssghrtn fqlegewrlw dlgargsrlp hsltdvdggk slhfphelkt
       61 ltlkeywqkn sprvpaganr nrktngsipq tatsggcqpp gdsatgfhre gptssatlkd
      121 lespcqerav vldsrsveis qlkntikslk qqkkqvehql eeekkannkk qkakrvlevq
      181 lqtlniqkee lntdlyhmkr slryfeeksk dlavrlqhsl qrkgelesvl sdvmatqkkk
      241 anqlsspska gtewkleqsm reeallkvql tqlkesfqqv qlerdeyseh lkgerarwqq
      301 rmrkmsqeic tlkkekqqdm rrveklersl sklknqmaep lppeppavps evelqhlrke
      361 lervagelqa qvknnqrisl lnqrqeerir eqeerlrkqe eriqeqhksl qqlakpqsvf
      421 eepnnenkst lqleqqvkel qeklgevelk sqeaqslqqq pdhylghlqq svatyqqqva
      481 ayqqltceke alyrq
//
LOCUS       XP_047288924             513 aa            linear   PRI 05-AUG-2025
DEFINITION  kunitz-type protease inhibitor 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047288924
VERSION     XP_047288924.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432968.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..513
                     /product="kunitz-type protease inhibitor 1 isoform X1"
                     /calculated_mol_wt=56755
     Region          50..139
                     /region_name="MANEC"
                     /note="MANEC domain; pfam07502"
                     /db_xref="CDD:462186"
     Region          245..303
                     /region_name="Kunitz_HAI1_1-like"
                     /note="Kunitz domain 1 of hepatocyte growth factor
                     activator inhibitor-1 (HAI-1); cd22623"
                     /db_xref="CDD:438666"
     Site            order(256..265,279,281,283..284,286,289,291)
                     /site_type="other"
                     /note="serine protease binding site [polypeptide binding]"
                     /db_xref="CDD:438666"
     Region          318..350
                     /region_name="LDLa"
                     /note="Low-density lipoprotein receptor domain class A;
                     smart00192"
                     /db_xref="CDD:197566"
     Site            order(324,332,343..344)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(336,339,343,349..350)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            346..350
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          374..434
                     /region_name="Kunitz_HAI1_2-like"
                     /note="Kunitz domain 2 of hepatocyte growth factor
                     activator inhibitor-1 (HAI1); cd22624"
                     /db_xref="CDD:438667"
     Site            order(381..385,387..389,404,408)
                     /site_type="other"
                     /note="putative serine protease binding site [polypeptide
                     binding]"
                     /db_xref="CDD:438667"
     CDS             1..513
                     /gene="SPINT1"
                     /gene_synonym="HAI; HAI1; MANSC2"
                     /coded_by="XM_047432968.1:297..1838"
                     /db_xref="GeneID:6692"
                     /db_xref="HGNC:HGNC:11246"
                     /db_xref="MIM:605123"
ORIGIN      
        1 mapartmara rlapagipav alwllctlgl qgtqagpppa ppglpagadc lnsftagvpg
       61 fvldtnasvs ngatflespt vrrgwdcvra ccttqncnla lvelqpdrge daiaacflin
      121 clyeqnfvck fapregfiny ltrevyrsyr qlrtqgfggs gipkawagid lkvqpqeplv
      181 lkdventdwr llrgdtdvrv erkdpnqvel wglkegtylf qltvtssdhp edtanvtvtv
      241 lstkqtedyc lasnkvgrcr gsfprwyydp teqicksfvy ggclgnknny lreeecilac
      301 rgvqgpsmer rhpvcsgtcq ptqfrcsngc cidsflecdd tpncpdasde aacekytsgf
      361 delqrihfps dkghcvdlpd tglckesipr wyynpfsehc arftyggcyg nknnfeeeqq
      421 clescrgisk kdvfglrrei pipstgsvem avavflvici vvvvailgyc ffknqrkdfh
      481 ghhhhppptp asstvstted tehlvynhtt rpl
//
LOCUS       XP_047288925             487 aa            linear   PRI 05-AUG-2025
DEFINITION  kunitz-type protease inhibitor 1 isoform X2 [Homo sapiens].
ACCESSION   XP_047288925
VERSION     XP_047288925.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432969.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..487
                     /product="kunitz-type protease inhibitor 1 isoform X2"
                     /calculated_mol_wt=53772
     Region          50..139
                     /region_name="MANEC"
                     /note="MANEC domain; pfam07502"
                     /db_xref="CDD:462186"
     Region          245..303
                     /region_name="Kunitz_HAI1_1-like"
                     /note="Kunitz domain 1 of hepatocyte growth factor
                     activator inhibitor-1 (HAI-1); cd22623"
                     /db_xref="CDD:438666"
     Site            order(256..265,279,281,283..284,286,289,291)
                     /site_type="other"
                     /note="serine protease binding site [polypeptide binding]"
                     /db_xref="CDD:438666"
     Region          348..408
                     /region_name="Kunitz_HAI1_2-like"
                     /note="Kunitz domain 2 of hepatocyte growth factor
                     activator inhibitor-1 (HAI1); cd22624"
                     /db_xref="CDD:438667"
     Site            order(355..359,361..363,378,382)
                     /site_type="other"
                     /note="putative serine protease binding site [polypeptide
                     binding]"
                     /db_xref="CDD:438667"
     CDS             1..487
                     /gene="SPINT1"
                     /gene_synonym="HAI; HAI1; MANSC2"
                     /coded_by="XM_047432969.1:297..1760"
                     /db_xref="GeneID:6692"
                     /db_xref="HGNC:HGNC:11246"
                     /db_xref="MIM:605123"
ORIGIN      
        1 mapartmara rlapagipav alwllctlgl qgtqagpppa ppglpagadc lnsftagvpg
       61 fvldtnasvs ngatflespt vrrgwdcvra ccttqncnla lvelqpdrge daiaacflin
      121 clyeqnfvck fapregfiny ltrevyrsyr qlrtqgfggs gipkawagid lkvqpqeplv
      181 lkdventdwr llrgdtdvrv erkdpnqvel wglkegtylf qltvtssdhp edtanvtvtv
      241 lstkqtedyc lasnkvgrcr gsfprwyydp teqicksfvy ggclgnknny lreeecilac
      301 rgvqggplrg ssgaqatfpq gpsmerrhpd tsgfdelqri hfpsdkghcv dlpdtglcke
      361 siprwyynpf sehcarftyg gcygnknnfe eeqqclescr giskkdvfgl rreipipstg
      421 svemavavfl vicivvvvai lgycffknqr kdfhghhhhp pptpasstvs ttedtehlvy
      481 nhttrpl
//
LOCUS       XP_047288926             471 aa            linear   PRI 05-AUG-2025
DEFINITION  kunitz-type protease inhibitor 1 isoform X3 [Homo sapiens].
ACCESSION   XP_047288926
VERSION     XP_047288926.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432970.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..471
                     /product="kunitz-type protease inhibitor 1 isoform X3"
                     /calculated_mol_wt=52260
     Region          50..139
                     /region_name="MANEC"
                     /note="MANEC domain; pfam07502"
                     /db_xref="CDD:462186"
     Region          245..303
                     /region_name="Kunitz_HAI1_1-like"
                     /note="Kunitz domain 1 of hepatocyte growth factor
                     activator inhibitor-1 (HAI-1); cd22623"
                     /db_xref="CDD:438666"
     Site            order(256..265,279,281,283..284,286,289,291)
                     /site_type="other"
                     /note="serine protease binding site [polypeptide binding]"
                     /db_xref="CDD:438666"
     Region          332..392
                     /region_name="Kunitz_HAI1_2-like"
                     /note="Kunitz domain 2 of hepatocyte growth factor
                     activator inhibitor-1 (HAI1); cd22624"
                     /db_xref="CDD:438667"
     Site            order(339..343,345..347,362,366)
                     /site_type="other"
                     /note="putative serine protease binding site [polypeptide
                     binding]"
                     /db_xref="CDD:438667"
     CDS             1..471
                     /gene="SPINT1"
                     /gene_synonym="HAI; HAI1; MANSC2"
                     /coded_by="XM_047432970.1:297..1712"
                     /db_xref="GeneID:6692"
                     /db_xref="HGNC:HGNC:11246"
                     /db_xref="MIM:605123"
ORIGIN      
        1 mapartmara rlapagipav alwllctlgl qgtqagpppa ppglpagadc lnsftagvpg
       61 fvldtnasvs ngatflespt vrrgwdcvra ccttqncnla lvelqpdrge daiaacflin
      121 clyeqnfvck fapregfiny ltrevyrsyr qlrtqgfggs gipkawagid lkvqpqeplv
      181 lkdventdwr llrgdtdvrv erkdpnqvel wglkegtylf qltvtssdhp edtanvtvtv
      241 lstkqtedyc lasnkvgrcr gsfprwyydp teqicksfvy ggclgnknny lreeecilac
      301 rgvqgpsmer rhpdtsgfde lqrihfpsdk ghcvdlpdtg lckesiprwy ynpfsehcar
      361 ftyggcygnk nnfeeeqqcl escrgiskkd vfglrreipi pstgsvemav avflvicivv
      421 vvailgycff knqrkdfhgh hhhppptpas stvsttedte hlvynhttrp l
//
LOCUS       XP_011520261             718 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor 12 isoform X1 [Homo sapiens].
ACCESSION   XP_011520261
VERSION     XP_011520261.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521959.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..718
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..718
                     /product="transcription factor 12 isoform X1"
                     /calculated_mol_wt=77132
     Region          607..691
                     /region_name="bHLH_E-protein_TCF4_E2-2"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     cd18945"
                     /db_xref="CDD:381515"
     Site            order(615,619,621..623,625,630,651..652)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381515"
     Site            order(628..629,632..633,635..636,639,643,653,656,660,663,
                     666..671)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381515"
     CDS             1..718
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /coded_by="XM_011521959.4:286..2442"
                     /db_xref="GeneID:6938"
                     /db_xref="HGNC:HGNC:11623"
                     /db_xref="MIM:600480"
ORIGIN      
        1 mnpqqqrmaa igtdkelsdl ldfsamfspp vnsgktrptt lgssqfsgsg ftdlntslqy
       61 fsiderggtt swgtsgqpsp sydssrgftd sphysdhlnd srlgahegls ptpfmnsnlm
      121 gktsergsfs lysrdtglpg cqssllrqdl glgspaqlss sgkpgtayys fsatssrrrp
      181 lhdsaaldpl qakkvrkvpp glpssvyaps pnsddfnres psypspkppt smfastffmq
      241 dgthnssdlw sssngmsqpg fggilgtsts hmsqsssygn lhshdrlsyp phsvsptdin
      301 tslppmssfh rgstssspyv aashtpping sdsilgtrgn aagssqtgda lgkalasiys
      361 pdhtsssfps npstpvgsps pltgtsqwpr pggqapssps yenslhslkn rveqqlhehl
      421 qdamsflkdv ceqsrmedrl drlddaihvl rnhavgpsts lpaghsdihs llgpshnapi
      481 gslnsnyggs slvassrsas mvgthredsv slngnhsvls stvttsstdl nhktqenyrg
      541 glqsqsgtvv tteiktenke kdenlhepps sddmksddes sqkdikvssr grtsstnede
      601 dlnpeqkier ekerrmanna rerlrvrdin eafkelgrmc qlhlksekpq tkllilhqav
      661 avilsleqqv rernlnpkaa clkrreeekv savsaepptt lpgthpglse ttnpmghm
//
LOCUS       XP_011520262             718 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor 12 isoform X1 [Homo sapiens].
ACCESSION   XP_011520262
VERSION     XP_011520262.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521960.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..718
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..718
                     /product="transcription factor 12 isoform X1"
                     /calculated_mol_wt=77132
     Region          607..691
                     /region_name="bHLH_E-protein_TCF4_E2-2"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     cd18945"
                     /db_xref="CDD:381515"
     Site            order(615,619,621..623,625,630,651..652)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381515"
     Site            order(628..629,632..633,635..636,639,643,653,656,660,663,
                     666..671)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381515"
     CDS             1..718
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /coded_by="XM_011521960.4:286..2442"
                     /db_xref="GeneID:6938"
                     /db_xref="HGNC:HGNC:11623"
                     /db_xref="MIM:600480"
ORIGIN      
        1 mnpqqqrmaa igtdkelsdl ldfsamfspp vnsgktrptt lgssqfsgsg ftdlntslqy
       61 fsiderggtt swgtsgqpsp sydssrgftd sphysdhlnd srlgahegls ptpfmnsnlm
      121 gktsergsfs lysrdtglpg cqssllrqdl glgspaqlss sgkpgtayys fsatssrrrp
      181 lhdsaaldpl qakkvrkvpp glpssvyaps pnsddfnres psypspkppt smfastffmq
      241 dgthnssdlw sssngmsqpg fggilgtsts hmsqsssygn lhshdrlsyp phsvsptdin
      301 tslppmssfh rgstssspyv aashtpping sdsilgtrgn aagssqtgda lgkalasiys
      361 pdhtsssfps npstpvgsps pltgtsqwpr pggqapssps yenslhslkn rveqqlhehl
      421 qdamsflkdv ceqsrmedrl drlddaihvl rnhavgpsts lpaghsdihs llgpshnapi
      481 gslnsnyggs slvassrsas mvgthredsv slngnhsvls stvttsstdl nhktqenyrg
      541 glqsqsgtvv tteiktenke kdenlhepps sddmksddes sqkdikvssr grtsstnede
      601 dlnpeqkier ekerrmanna rerlrvrdin eafkelgrmc qlhlksekpq tkllilhqav
      661 avilsleqqv rernlnpkaa clkrreeekv savsaepptt lpgthpglse ttnpmghm
//
LOCUS       XP_011520263             717 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor 12 isoform X2 [Homo sapiens].
ACCESSION   XP_011520263
VERSION     XP_011520263.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521961.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..717
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..717
                     /product="transcription factor 12 isoform X2"
                     /calculated_mol_wt=77045
     Region          606..690
                     /region_name="bHLH_E-protein_TCF4_E2-2"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     cd18945"
                     /db_xref="CDD:381515"
     Site            order(614,618,620..622,624,629,650..651)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381515"
     Site            order(627..628,631..632,634..635,638,642,652,655,659,662,
                     665..670)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381515"
     CDS             1..717
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /coded_by="XM_011521961.4:286..2439"
                     /db_xref="GeneID:6938"
                     /db_xref="HGNC:HGNC:11623"
                     /db_xref="MIM:600480"
ORIGIN      
        1 mnpqqqrmaa igtdkelsdl ldfsamfspp vnsgktrptt lgssqfsgsg ftdlntslqy
       61 fsiderggtt swgtsgqpsp sydssrgftd sphysdhlnd srlgahegls ptpfmnsnlm
      121 gktsergsfs lysrdtglpg cqssllrqdl glgspaqlss sgkpgtayys fsatssrrrp
      181 lhdsaaldpl qakkvrkvpp glpssvyaps pnsddfnres psypspkppt smfastffmq
      241 dgthnssdlw sssngmsqpg fggilgtsts hmsqsssygn lhshdrlsyp phsvsptdin
      301 tslppmssfh rgstssspyv aashtpping sdsilgtrgn aagssqtgda lgkalasiys
      361 pdhtsssfps npstpvgsps pltgtsqwpr pggqapssps yenslhslkn rveqqlhehl
      421 qdamsflkdv ceqsrmedrl drlddaihvl rnhavgpsts lpaghsdihs llgpshnapi
      481 gslnsnyggs slvassrsas mvgthredsv slngnhsvls stvttsstdl nhktqenyrg
      541 glqsqsgtvv tteiktenke kdenlhepps sddmksddes sqkdikvssr grtstneded
      601 lnpeqkiere kerrmannar erlrvrdine afkelgrmcq lhlksekpqt kllilhqava
      661 vilsleqqvr ernlnpkaac lkrreeekvs avsaeppttl pgthpglset tnpmghm
//
LOCUS       XP_011520264             694 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor 12 isoform X3 [Homo sapiens].
ACCESSION   XP_011520264
VERSION     XP_011520264.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521962.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..694
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..694
                     /product="transcription factor 12 isoform X3"
                     /calculated_mol_wt=74252
     Region          583..667
                     /region_name="bHLH_E-protein_TCF4_E2-2"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     cd18945"
                     /db_xref="CDD:381515"
     Site            order(591,595,597..599,601,606,627..628)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381515"
     Site            order(604..605,608..609,611..612,615,619,629,632,636,639,
                     642..647)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381515"
     CDS             1..694
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /coded_by="XM_011521962.4:286..2370"
                     /db_xref="GeneID:6938"
                     /db_xref="HGNC:HGNC:11623"
                     /db_xref="MIM:600480"
ORIGIN      
        1 mnpqqqrmaa igtdkelsdl ldfsamfspp vnsgktrptt lgssqfsgsg ftdlntslqy
       61 fsiderggtt swgtsgqpsp sydssrgftd sphysdhlnd srlgahegls ptpfmnsnlm
      121 gktsergsfs lysrdtglpg cqssllrqdl glgspaqlss sgkpgtayys fsatssrrrp
      181 lhdsaaldpl qakkvrkvpp glpssvyaps pnsddfnres psypspkppt smfastffmq
      241 dgthnssdlw sssngmsqpg fggilgtsts hmsqsssygn lhshdrlsyp phsvsptdin
      301 tslppmssfh rgstssspyv aashtpping sdsilgtrgn aagssqtgda lgkalasiys
      361 pdhtsssfps npstpvgsps pltgtsqwpr pggqapssps yenslhslqs rmedrldrld
      421 daihvlrnha vgpstslpag hsdihsllgp shnapigsln snyggsslva ssrsasmvgt
      481 hredsvslng nhsvlsstvt tsstdlnhkt qenyrgglqs qsgtvvttei ktenkekden
      541 lheppssddm ksddessqkd ikvssrgrts stnededlnp eqkiereker rmannarerl
      601 rvrdineafk elgrmcqlhl ksekpqtkll ilhqavavil sleqqvrern lnpkaaclkr
      661 reeekvsavs aeppttlpgt hpglsettnp mghm
//
LOCUS       XP_047288927             694 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor 12 isoform X3 [Homo sapiens].
ACCESSION   XP_047288927
VERSION     XP_047288927.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432971.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..694
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..694
                     /product="transcription factor 12 isoform X3"
                     /calculated_mol_wt=74252
     Region          583..667
                     /region_name="bHLH_E-protein_TCF4_E2-2"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     cd18945"
                     /db_xref="CDD:381515"
     Site            order(591,595,597..599,601,606,627..628)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381515"
     Site            order(604..605,608..609,611..612,615,619,629,632,636,639,
                     642..647)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381515"
     CDS             1..694
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /coded_by="XM_047432971.1:286..2370"
                     /db_xref="GeneID:6938"
                     /db_xref="HGNC:HGNC:11623"
                     /db_xref="MIM:600480"
ORIGIN      
        1 mnpqqqrmaa igtdkelsdl ldfsamfspp vnsgktrptt lgssqfsgsg ftdlntslqy
       61 fsiderggtt swgtsgqpsp sydssrgftd sphysdhlnd srlgahegls ptpfmnsnlm
      121 gktsergsfs lysrdtglpg cqssllrqdl glgspaqlss sgkpgtayys fsatssrrrp
      181 lhdsaaldpl qakkvrkvpp glpssvyaps pnsddfnres psypspkppt smfastffmq
      241 dgthnssdlw sssngmsqpg fggilgtsts hmsqsssygn lhshdrlsyp phsvsptdin
      301 tslppmssfh rgstssspyv aashtpping sdsilgtrgn aagssqtgda lgkalasiys
      361 pdhtsssfps npstpvgsps pltgtsqwpr pggqapssps yenslhslqs rmedrldrld
      421 daihvlrnha vgpstslpag hsdihsllgp shnapigsln snyggsslva ssrsasmvgt
      481 hredsvslng nhsvlsstvt tsstdlnhkt qenyrgglqs qsgtvvttei ktenkekden
      541 lheppssddm ksddessqkd ikvssrgrts stnededlnp eqkiereker rmannarerl
      601 rvrdineafk elgrmcqlhl ksekpqtkll ilhqavavil sleqqvrern lnpkaaclkr
      661 reeekvsavs aeppttlpgt hpglsettnp mghm
//
LOCUS       XP_011520265             693 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor 12 isoform X4 [Homo sapiens].
ACCESSION   XP_011520265
VERSION     XP_011520265.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521963.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..693
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..693
                     /product="transcription factor 12 isoform X4"
                     /calculated_mol_wt=74165
     Region          582..666
                     /region_name="bHLH_E-protein_TCF4_E2-2"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     cd18945"
                     /db_xref="CDD:381515"
     Site            order(590,594,596..598,600,605,626..627)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381515"
     Site            order(603..604,607..608,610..611,614,618,628,631,635,638,
                     641..646)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381515"
     CDS             1..693
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /coded_by="XM_011521963.4:286..2367"
                     /db_xref="GeneID:6938"
                     /db_xref="HGNC:HGNC:11623"
                     /db_xref="MIM:600480"
ORIGIN      
        1 mnpqqqrmaa igtdkelsdl ldfsamfspp vnsgktrptt lgssqfsgsg ftdlntslqy
       61 fsiderggtt swgtsgqpsp sydssrgftd sphysdhlnd srlgahegls ptpfmnsnlm
      121 gktsergsfs lysrdtglpg cqssllrqdl glgspaqlss sgkpgtayys fsatssrrrp
      181 lhdsaaldpl qakkvrkvpp glpssvyaps pnsddfnres psypspkppt smfastffmq
      241 dgthnssdlw sssngmsqpg fggilgtsts hmsqsssygn lhshdrlsyp phsvsptdin
      301 tslppmssfh rgstssspyv aashtpping sdsilgtrgn aagssqtgda lgkalasiys
      361 pdhtsssfps npstpvgsps pltgtsqwpr pggqapssps yenslhslqs rmedrldrld
      421 daihvlrnha vgpstslpag hsdihsllgp shnapigsln snyggsslva ssrsasmvgt
      481 hredsvslng nhsvlsstvt tsstdlnhkt qenyrgglqs qsgtvvttei ktenkekden
      541 lheppssddm ksddessqkd ikvssrgrts tnededlnpe qkierekerr mannarerlr
      601 vrdineafke lgrmcqlhlk sekpqtklli lhqavavils leqqvrernl npkaaclkrr
      661 eeekvsavsa eppttlpgth pglsettnpm ghm
//
LOCUS       XP_047288928             693 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor 12 isoform X4 [Homo sapiens].
ACCESSION   XP_047288928
VERSION     XP_047288928.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432972.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..693
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..693
                     /product="transcription factor 12 isoform X4"
                     /calculated_mol_wt=74165
     Region          582..666
                     /region_name="bHLH_E-protein_TCF4_E2-2"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     cd18945"
                     /db_xref="CDD:381515"
     Site            order(590,594,596..598,600,605,626..627)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381515"
     Site            order(603..604,607..608,610..611,614,618,628,631,635,638,
                     641..646)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381515"
     CDS             1..693
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /coded_by="XM_047432972.1:286..2367"
                     /db_xref="GeneID:6938"
                     /db_xref="HGNC:HGNC:11623"
                     /db_xref="MIM:600480"
ORIGIN      
        1 mnpqqqrmaa igtdkelsdl ldfsamfspp vnsgktrptt lgssqfsgsg ftdlntslqy
       61 fsiderggtt swgtsgqpsp sydssrgftd sphysdhlnd srlgahegls ptpfmnsnlm
      121 gktsergsfs lysrdtglpg cqssllrqdl glgspaqlss sgkpgtayys fsatssrrrp
      181 lhdsaaldpl qakkvrkvpp glpssvyaps pnsddfnres psypspkppt smfastffmq
      241 dgthnssdlw sssngmsqpg fggilgtsts hmsqsssygn lhshdrlsyp phsvsptdin
      301 tslppmssfh rgstssspyv aashtpping sdsilgtrgn aagssqtgda lgkalasiys
      361 pdhtsssfps npstpvgsps pltgtsqwpr pggqapssps yenslhslqs rmedrldrld
      421 daihvlrnha vgpstslpag hsdihsllgp shnapigsln snyggsslva ssrsasmvgt
      481 hredsvslng nhsvlsstvt tsstdlnhkt qenyrgglqs qsgtvvttei ktenkekden
      541 lheppssddm ksddessqkd ikvssrgrts tnededlnpe qkierekerr mannarerlr
      601 vrdineafke lgrmcqlhlk sekpqtklli lhqavavils leqqvrernl npkaaclkrr
      661 eeekvsavsa eppttlpgth pglsettnpm ghm
//
LOCUS       XP_016878009             681 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor 12 isoform X5 [Homo sapiens].
ACCESSION   XP_016878009
VERSION     XP_016878009.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022520.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..681
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..681
                     /product="transcription factor 12 isoform X5"
                     /calculated_mol_wt=72747
     Region          570..654
                     /region_name="bHLH_E-protein_TCF4_E2-2"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     cd18945"
                     /db_xref="CDD:381515"
     Site            order(578,582,584..586,588,593,614..615)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381515"
     Site            order(591..592,595..596,598..599,602,606,616,619,623,626,
                     629..634)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381515"
     CDS             1..681
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /coded_by="XM_017022520.3:286..2331"
                     /db_xref="GeneID:6938"
                     /db_xref="HGNC:HGNC:11623"
                     /db_xref="MIM:600480"
ORIGIN      
        1 mnpqqqrmaa igtdkelsdl ldfsamfspp vnsgktrptt lgssqfsgsg iderggttsw
       61 gtsgqpspsy dssrgftdsp hysdhlndsr lgaheglspt pfmnsnlmgk tsergsfsly
      121 srdtglpgcq ssllrqdlgl gspaqlsssg kpgtayysfs atssrrrplh dsaaldplqa
      181 kkvrkvppgl pssvyapspn sddfnresps ypspkpptsm fastffmqdg thnssdlwss
      241 sngmsqpgfg gilgtstshm sqsssygnlh shdrlsypph svsptdints lppmssfhrg
      301 stssspyvaa shtppingsd silgtrgnaa gssqtgdalg kalasiyspd htsssfpsnp
      361 stpvgspspl tgtsqwprpg gqapsspsye nslhslqsrm edrldrldda ihvlrnhavg
      421 pstslpaghs dihsllgpsh napigslnsn yggsslvass rsasmvgthr edsvslngnh
      481 svlsstvtts stdlnhktqe nyrgglqsqs gtvvtteikt enkekdenlh eppssddmks
      541 ddessqkdik vssrgrtstn ededlnpeqk ierekerrma nnarerlrvr dineafkelg
      601 rmcqlhlkse kpqtkllilh qavavilsle qqvrernlnp kaaclkrree ekvsavsaep
      661 pttlpgthpg lsettnpmgh m
//
LOCUS       XP_047288929             681 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor 12 isoform X5 [Homo sapiens].
ACCESSION   XP_047288929
VERSION     XP_047288929.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432973.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..681
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..681
                     /product="transcription factor 12 isoform X5"
                     /calculated_mol_wt=72747
     Region          570..654
                     /region_name="bHLH_E-protein_TCF4_E2-2"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     cd18945"
                     /db_xref="CDD:381515"
     Site            order(578,582,584..586,588,593,614..615)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381515"
     Site            order(591..592,595..596,598..599,602,606,616,619,623,626,
                     629..634)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381515"
     CDS             1..681
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /coded_by="XM_047432973.1:286..2331"
                     /db_xref="GeneID:6938"
                     /db_xref="HGNC:HGNC:11623"
                     /db_xref="MIM:600480"
ORIGIN      
        1 mnpqqqrmaa igtdkelsdl ldfsamfspp vnsgktrptt lgssqfsgsg iderggttsw
       61 gtsgqpspsy dssrgftdsp hysdhlndsr lgaheglspt pfmnsnlmgk tsergsfsly
      121 srdtglpgcq ssllrqdlgl gspaqlsssg kpgtayysfs atssrrrplh dsaaldplqa
      181 kkvrkvppgl pssvyapspn sddfnresps ypspkpptsm fastffmqdg thnssdlwss
      241 sngmsqpgfg gilgtstshm sqsssygnlh shdrlsypph svsptdints lppmssfhrg
      301 stssspyvaa shtppingsd silgtrgnaa gssqtgdalg kalasiyspd htsssfpsnp
      361 stpvgspspl tgtsqwprpg gqapsspsye nslhslqsrm edrldrldda ihvlrnhavg
      421 pstslpaghs dihsllgpsh napigslnsn yggsslvass rsasmvgthr edsvslngnh
      481 svlsstvtts stdlnhktqe nyrgglqsqs gtvvtteikt enkekdenlh eppssddmks
      541 ddessqkdik vssrgrtstn ededlnpeqk ierekerrma nnarerlrvr dineafkelg
      601 rmcqlhlkse kpqtkllilh qavavilsle qqvrernlnp kaaclkrree ekvsavsaep
      661 pttlpgthpg lsettnpmgh m
//
LOCUS       XP_047288930             535 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor 12 isoform X6 [Homo sapiens].
ACCESSION   XP_047288930
VERSION     XP_047288930.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432974.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..535
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..535
                     /product="transcription factor 12 isoform X6"
                     /calculated_mol_wt=57805
     Region          424..508
                     /region_name="bHLH_E-protein_TCF4_E2-2"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     cd18945"
                     /db_xref="CDD:381515"
     Site            order(432,436,438..440,442,447,468..469)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381515"
     Site            order(445..446,449..450,452..453,456,460,470,473,477,480,
                     483..488)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381515"
     CDS             1..535
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /coded_by="XM_047432974.1:93..1700"
                     /db_xref="GeneID:6938"
                     /db_xref="HGNC:HGNC:11623"
                     /db_xref="MIM:600480"
ORIGIN      
        1 mycaypvpgm gsnslmyyyn gktvyapspn sddfnresps ypspkpptsm fastffmqdg
       61 thnssdlwss sngmsqpgfg gilgtstshm sqsssygnlh shdrlsypph svsptdints
      121 lppmssfhrg stssspyvaa shtppingsd silgtrgnaa gssqtgdalg kalasiyspd
      181 htsssfpsnp stpvgspspl tgtsqwprpg gqapsspsye nslhslknrv eqqlhehlqd
      241 amsflkdvce qsrmedrldr lddaihvlrn havgpstslp aghsdihsll gpshnapigs
      301 lnsnyggssl vassrsasmv gthredsvsl ngnhsvlsst vttsstdlnh ktqenyrggl
      361 qsqsgtvvtt eiktenkekd enlheppssd dmksddessq kdikvssrgr tstnededln
      421 peqkiereke rrmannarer lrvrdineaf kelgrmcqlh lksekpqtkl lilhqavavi
      481 lsleqqvrer nlnpkaaclk rreeekvsav saeppttlpg thpglsettn pmghm
//
LOCUS       XP_047288931             512 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor 12 isoform X7 [Homo sapiens].
ACCESSION   XP_047288931
VERSION     XP_047288931.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432975.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..512
                     /product="transcription factor 12 isoform X7"
                     /calculated_mol_wt=55012
     Region          401..485
                     /region_name="bHLH_E-protein_TCF4_E2-2"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     cd18945"
                     /db_xref="CDD:381515"
     Site            order(409,413,415..417,419,424,445..446)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381515"
     Site            order(422..423,426..427,429..430,433,437,447,450,454,457,
                     460..465)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381515"
     CDS             1..512
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /coded_by="XM_047432975.1:93..1631"
                     /db_xref="GeneID:6938"
                     /db_xref="HGNC:HGNC:11623"
                     /db_xref="MIM:600480"
ORIGIN      
        1 mycaypvpgm gsnslmyyyn gktvyapspn sddfnresps ypspkpptsm fastffmqdg
       61 thnssdlwss sngmsqpgfg gilgtstshm sqsssygnlh shdrlsypph svsptdints
      121 lppmssfhrg stssspyvaa shtppingsd silgtrgnaa gssqtgdalg kalasiyspd
      181 htsssfpsnp stpvgspspl tgtsqwprpg gqapsspsye nslhslqsrm edrldrldda
      241 ihvlrnhavg pstslpaghs dihsllgpsh napigslnsn yggsslvass rsasmvgthr
      301 edsvslngnh svlsstvtts stdlnhktqe nyrgglqsqs gtvvtteikt enkekdenlh
      361 eppssddmks ddessqkdik vssrgrtsst nededlnpeq kierekerrm annarerlrv
      421 rdineafkel grmcqlhlks ekpqtkllil hqavavilsl eqqvrernln pkaaclkrre
      481 eekvsavsae ppttlpgthp glsettnpmg hm
//
LOCUS       XP_011520271             511 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor 12 isoform X8 [Homo sapiens].
ACCESSION   XP_011520271
VERSION     XP_011520271.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521969.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..511
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..511
                     /product="transcription factor 12 isoform X8"
                     /calculated_mol_wt=54924
     Region          400..484
                     /region_name="bHLH_E-protein_TCF4_E2-2"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     cd18945"
                     /db_xref="CDD:381515"
     Site            order(408,412,414..416,418,423,444..445)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381515"
     Site            order(421..422,425..426,428..429,432,436,446,449,453,456,
                     459..464)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381515"
     CDS             1..511
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /coded_by="XM_011521969.2:93..1628"
                     /db_xref="GeneID:6938"
                     /db_xref="HGNC:HGNC:11623"
                     /db_xref="MIM:600480"
ORIGIN      
        1 mycaypvpgm gsnslmyyyn gktvyapspn sddfnresps ypspkpptsm fastffmqdg
       61 thnssdlwss sngmsqpgfg gilgtstshm sqsssygnlh shdrlsypph svsptdints
      121 lppmssfhrg stssspyvaa shtppingsd silgtrgnaa gssqtgdalg kalasiyspd
      181 htsssfpsnp stpvgspspl tgtsqwprpg gqapsspsye nslhslqsrm edrldrldda
      241 ihvlrnhavg pstslpaghs dihsllgpsh napigslnsn yggsslvass rsasmvgthr
      301 edsvslngnh svlsstvtts stdlnhktqe nyrgglqsqs gtvvtteikt enkekdenlh
      361 eppssddmks ddessqkdik vssrgrtstn ededlnpeqk ierekerrma nnarerlrvr
      421 dineafkelg rmcqlhlkse kpqtkllilh qavavilsle qqvrernlnp kaaclkrree
      481 ekvsavsaep pttlpgthpg lsettnpmgh m
//
LOCUS       XP_047288932             511 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor 12 isoform X8 [Homo sapiens].
ACCESSION   XP_047288932
VERSION     XP_047288932.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432976.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..511
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..511
                     /product="transcription factor 12 isoform X8"
                     /calculated_mol_wt=54924
     Region          400..484
                     /region_name="bHLH_E-protein_TCF4_E2-2"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     cd18945"
                     /db_xref="CDD:381515"
     Site            order(408,412,414..416,418,423,444..445)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381515"
     Site            order(421..422,425..426,428..429,432,436,446,449,453,456,
                     459..464)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381515"
     CDS             1..511
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /coded_by="XM_047432976.1:93..1628"
                     /db_xref="GeneID:6938"
                     /db_xref="HGNC:HGNC:11623"
                     /db_xref="MIM:600480"
ORIGIN      
        1 mycaypvpgm gsnslmyyyn gktvyapspn sddfnresps ypspkpptsm fastffmqdg
       61 thnssdlwss sngmsqpgfg gilgtstshm sqsssygnlh shdrlsypph svsptdints
      121 lppmssfhrg stssspyvaa shtppingsd silgtrgnaa gssqtgdalg kalasiyspd
      181 htsssfpsnp stpvgspspl tgtsqwprpg gqapsspsye nslhslqsrm edrldrldda
      241 ihvlrnhavg pstslpaghs dihsllgpsh napigslnsn yggsslvass rsasmvgthr
      301 edsvslngnh svlsstvtts stdlnhktqe nyrgglqsqs gtvvtteikt enkekdenlh
      361 eppssddmks ddessqkdik vssrgrtstn ededlnpeqk ierekerrma nnarerlrvr
      421 dineafkelg rmcqlhlkse kpqtkllilh qavavilsle qqvrernlnp kaaclkrree
      481 ekvsavsaep pttlpgthpg lsettnpmgh m
//
LOCUS       XP_047288933             490 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor 12 isoform X9 [Homo sapiens].
ACCESSION   XP_047288933
VERSION     XP_047288933.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432977.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..490
                     /product="transcription factor 12 isoform X9"
                     /calculated_mol_wt=53247
     Region          379..463
                     /region_name="bHLH_E-protein_TCF4_E2-2"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     cd18945"
                     /db_xref="CDD:381515"
     Site            order(387,391,393..395,397,402,423..424)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381515"
     Site            order(400..401,404..405,407..408,411,415,425,428,432,435,
                     438..443)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381515"
     CDS             1..490
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /coded_by="XM_047432977.1:119..1591"
                     /db_xref="GeneID:6938"
                     /db_xref="HGNC:HGNC:11623"
                     /db_xref="MIM:600480"
ORIGIN      
        1 mtlqrlipck qkksercllv clllymhhpq iqmistvnll vihllshqpv cslalslcks
       61 ypphsvsptd intslppmss fhrgstsssp yvaashtppi ngsdsilgtr gnaagssqtg
      121 dalgkalasi yspdhtsssf psnpstpvgs pspltgtsqw prpggqapss psyenslhsl
      181 knrveqqlhe hlqdamsflk dvceqsrmed rldrlddaih vlrnhavgps tslpaghsdi
      241 hsllgpshna pigslnsnyg gsslvassrs asmvgthred svslngnhsv lsstvttsst
      301 dlnhktqeny rgglqsqsgt vvtteikten kekdenlhep pssddmksdd essqkdikvs
      361 srgrtsstne dedlnpeqki erekerrman narerlrvrd ineafkelgr mcqlhlksek
      421 pqtkllilhq avavilsleq qvrernlnpk aaclkrreee kvsavsaepp ttlpgthpgl
      481 settnpmghm
//
LOCUS       XP_011520268             470 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor 12 isoform X10 [Homo sapiens].
ACCESSION   XP_011520268
VERSION     XP_011520268.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521966.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..470
                     /product="transcription factor 12 isoform X10"
                     /calculated_mol_wt=50907
     Region          359..443
                     /region_name="bHLH_E-protein_TCF4_E2-2"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     cd18945"
                     /db_xref="CDD:381515"
     Site            order(367,371,373..375,377,382,403..404)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381515"
     Site            order(380..381,384..385,387..388,391,395,405,408,412,415,
                     418..423)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381515"
     CDS             1..470
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /coded_by="XM_011521966.3:151..1563"
                     /db_xref="GeneID:6938"
                     /db_xref="HGNC:HGNC:11623"
                     /db_xref="MIM:600480"
ORIGIN      
        1 mgkrymhhpq iqmistvnll vihllshqpv cslalslcks ypphsvsptd intslppmss
       61 fhrgstsssp yvaashtppi ngsdsilgtr gnaagssqtg dalgkalasi yspdhtsssf
      121 psnpstpvgs pspltgtsqw prpggqapss psyenslhsl knrveqqlhe hlqdamsflk
      181 dvceqsrmed rldrlddaih vlrnhavgps tslpaghsdi hsllgpshna pigslnsnyg
      241 gsslvassrs asmvgthred svslngnhsv lsstvttsst dlnhktqeny rgglqsqsgt
      301 vvtteikten kekdenlhep pssddmksdd essqkdikvs srgrtsstne dedlnpeqki
      361 erekerrman narerlrvrd ineafkelgr mcqlhlksek pqtkllilhq avavilsleq
      421 qvrernlnpk aaclkrreee kvsavsaepp ttlpgthpgl settnpmghm
//
LOCUS       XP_047288934             466 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor 12 isoform X11 [Homo sapiens].
ACCESSION   XP_047288934
VERSION     XP_047288934.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432978.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..466
                     /product="transcription factor 12 isoform X11"
                     /calculated_mol_wt=50366
     Region          355..439
                     /region_name="bHLH_E-protein_TCF4_E2-2"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     transcription factor 4 (TCF-4) and similar proteins;
                     cd18945"
                     /db_xref="CDD:381515"
     Site            order(363,367,369..371,373,378,399..400)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381515"
     Site            order(376..377,380..381,383..384,387,391,401,404,408,411,
                     414..419)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381515"
     CDS             1..466
                     /gene="TCF12"
                     /gene_synonym="bHLHb20; CRS3; HEB; HH26; HsT17266; HTF4;
                     p64; TCF-12"
                     /coded_by="XM_047432978.1:113..1513"
                     /db_xref="GeneID:6938"
                     /db_xref="HGNC:HGNC:11623"
                     /db_xref="MIM:600480"
ORIGIN      
        1 mtlqrlipck qkksercllv clllymhhpq iqmistvnll vihllshqpv cslalslcks
       61 ypphsvsptd intslppmss fhrgstsssp yvaashtppi ngsdsilgtr gnaagssqtg
      121 dalgkalasi yspdhtsssf psnpstpvgs pspltgtsqw prpggqapss psyenslhsl
      181 qsrmedrldr lddaihvlrn havgpstslp aghsdihsll gpshnapigs lnsnyggssl
      241 vassrsasmv gthredsvsl ngnhsvlsst vttsstdlnh ktqenyrggl qsqsgtvvtt
      301 eiktenkekd enlheppssd dmksddessq kdikvssrgr tsstnededl npeqkierek
      361 errmannare rlrvrdinea fkelgrmcql hlksekpqtk llilhqavav ilsleqqvre
      421 rnlnpkaacl krreeekvsa vsaeppttlp gthpglsett npmghm
//
LOCUS       XP_047288935             377 aa            linear   PRI 05-AUG-2025
DEFINITION  actin, alpha cardiac muscle 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047288935
VERSION     XP_047288935.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432979.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..377
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..377
                     /product="actin, alpha cardiac muscle 1 isoform X1"
                     /calculated_mol_wt=41888
     Region          8..372
                     /region_name="ASKHA_NBD_actin"
                     /note="nucleotide-binding domain (NBD) of actin and
                     similar proteins; cd10224"
                     /db_xref="CDD:466823"
     CDS             1..377
                     /gene="ACTC1"
                     /gene_synonym="ACTC; ASD5; CMD1R; CMH11; LVNC4"
                     /coded_by="XM_047432979.1:430..1563"
                     /db_xref="GeneID:70"
                     /db_xref="HGNC:HGNC:143"
                     /db_xref="MIM:102540"
ORIGIN      
        1 mcddeettal vcdngsglvk agfagddapr avfpsivgrp rhqgvmvgmg qkdsyvgdea
       61 qskrgiltlk ypiehgiitn wddmekiwhh tfynelrvap eehptlltea plnpkanrek
      121 mtqimfetfn vpamyvaiqa vlslyasgrt tgivldsgdg vthnvpiyeg yalphaimrl
      181 dlagrdltdy lmkiltergy sfvttaerei vrdikeklcy valdfenema taasssslek
      241 syelpdgqvi tignerfrcp etlfqpsfig mesagihett ynsimkcdid irkdlyannv
      301 lsggttmypg iadrmqkeit alapstmkik iiapperkys vwiggsilas lstfqqmwis
      361 kqeydeagps ivhrkcf
//
LOCUS       XP_047288936            1170 aa            linear   PRI 05-AUG-2025
DEFINITION  thrombospondin-1 isoform X1 [Homo sapiens].
ACCESSION   XP_047288936
VERSION     XP_047288936.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432980.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1170
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1170
                     /product="thrombospondin-1 isoform X1"
                     /calculated_mol_wt=129252
     Region          26..221
                     /region_name="TSPN"
                     /note="Thrombospondin N-terminal -like domains;
                     smart00210"
                     /db_xref="CDD:214560"
     Region          318..372
                     /region_name="VWC"
                     /note="von Willebrand factor type C domain; pfam00093"
                     /db_xref="CDD:278520"
     Region          383..428
                     /region_name="TSP_1"
                     /note="Thrombospondin type 1 domain; pfam00090"
                     /db_xref="CDD:459668"
     Region          438..490
                     /region_name="TSP1"
                     /note="Thrombospondin type 1 repeats; smart00209"
                     /db_xref="CDD:214559"
     Region          495..547
                     /region_name="TSP1"
                     /note="Thrombospondin type 1 repeats; smart00209"
                     /db_xref="CDD:214559"
     Region          650..689
                     /region_name="EGF_3"
                     /note="EGF domain; pfam12947"
                     /db_xref="CDD:463759"
     Region          691..726
                     /region_name="TSP3 repeat_1C"
                     /note="TSP3 repeat_1C [structural motif]"
                     /db_xref="CDD:275367"
     Region          763..785
                     /region_name="TSP3 repeat_short"
                     /note="TSP3 repeat_short [structural motif]"
                     /db_xref="CDD:275365"
     Region          786..821
                     /region_name="TSP_3"
                     /note="Thrombospondin type 3 repeat; pfam02412"
                     /db_xref="CDD:367074"
     Region          787..821
                     /region_name="TSP3 repeat_long"
                     /note="TSP3 repeat_long [structural motif]"
                     /db_xref="CDD:275366"
     Region          822..844
                     /region_name="TSP3 repeat_short"
                     /note="TSP3 repeat_short [structural motif]"
                     /db_xref="CDD:275366"
     Region          845..882
                     /region_name="TSP3 repeat_long"
                     /note="TSP3 repeat_long [structural motif]"
                     /db_xref="CDD:275365"
     Region          846..882
                     /region_name="TSP_3"
                     /note="Thrombospondin type 3 repeat; pfam02412"
                     /db_xref="CDD:367074"
     Region          883..918
                     /region_name="TSP3 repeat_short"
                     /note="TSP3 repeat_short [structural motif]"
                     /db_xref="CDD:275366"
     Region          919..952
                     /region_name="TSP_3"
                     /note="Thrombospondin type 3 repeat; pfam02412"
                     /db_xref="CDD:367074"
     Region          972..1169
                     /region_name="TSP_C"
                     /note="Thrombospondin C-terminal region; pfam05735"
                     /db_xref="CDD:461725"
     CDS             1..1170
                     /gene="THBS1"
                     /gene_synonym="THBS; THBS-1; TSP; TSP-1; TSP1"
                     /coded_by="XM_047432980.1:301..3813"
                     /db_xref="GeneID:7057"
                     /db_xref="HGNC:HGNC:11785"
                     /db_xref="MIM:188060"
ORIGIN      
        1 mglawglgvl flmhvcgtnr ipesggdnsv fdifeltgaa rkgsgrrlvk gpdpsspafr
       61 iedanlippv pddkfqdlvd avraekgfll laslrqmkkt rgtllalerk dhsgqvfsvv
      121 sngkagtldl sltvqgkqhv vsveeallat gqwksitlfv qedraqlyid cekmenaeld
      181 vpiqsvftrd lasiarlria kggvndnfqg vlqnvrfvfg ttpedilrnk gcssstsvll
      241 tldnnvvngs spairtnyig hktkdlqaic giscdelssm vlelrglrti vttlqdsirk
      301 vteenkelan elrrpplcyh ngvqyrnnee wtvdsctech cqnsvtickk vscpimpcsn
      361 atvpdgeccp rcwpsdsadd gwspwsewts cstscgngiq qrgrscdsln nrcegssvqt
      421 rtchiqecdk rfkqdggwsh wspwsscsvt cgdgvitrir lcnspspqmn gkpcegeare
      481 tkackkdacp inggwgpwsp wdicsvtcgg gvqkrsrlcn nptpqfggkd cvgdvtenqi
      541 cnkqdcpidg clsnpcfagv kctsypdgsw kcgacppgys gngiqctdvd eckevpdacf
      601 nhngehrcen tdpgynclpc pprftgsqpf gqgvehatan kqvckprnpc tdgthdcnkn
      661 akcnylghys dpmyrceckp gyagngiicg edtdldgwpn enlvcvanat yhckkdncpn
      721 lpnsgqedyd kdgigdacdd dddndkipdd rdncpfhynp aqydydrddv gdrcdncpyn
      781 hnpdqadtdn ngegdacaad idgdgilner dncqyvynvd qrdtdmdgvg dqcdncpleh
      841 npdqldsdsd rigdtcdnnq didedghqnn ldncpyvpna nqadhdkdgk gdacdhdddn
      901 dgipddkdnc rlvpnpdqkd sdgdgrgdac kddfdhdsvp diddicpenv disetdfrrf
      961 qmipldpkgt sqndpnwvvr hqgkelvqtv ncdpglavgy defnavdfsg tffinterdd
     1021 dyagfvfgyq sssrfyvvmw kqvtqsywdt nptraqgysg lsvkvvnstt gpgehlrnal
     1081 whtgntpgqv rtlwhdprhi gwkdftayrw rlshrpktgf irvvmyegkk imadsgpiyd
     1141 ktyaggrlgl fvfsqemvff sdlkyecrdp
//
LOCUS       XP_011520273            1112 aa            linear   PRI 05-AUG-2025
DEFINITION  thrombospondin-1 isoform X2 [Homo sapiens].
ACCESSION   XP_011520273
VERSION     XP_011520273.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521971.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1112
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1112
                     /product="thrombospondin-1 isoform X2"
                     /calculated_mol_wt=123031
     Region          26..221
                     /region_name="TSPN"
                     /note="Thrombospondin N-terminal -like domains;
                     smart00210"
                     /db_xref="CDD:214560"
     Region          318..372
                     /region_name="VWC"
                     /note="von Willebrand factor type C domain; pfam00093"
                     /db_xref="CDD:278520"
     Region          383..428
                     /region_name="TSP_1"
                     /note="Thrombospondin type 1 domain; pfam00090"
                     /db_xref="CDD:459668"
     Region          438..490
                     /region_name="TSP1"
                     /note="Thrombospondin type 1 repeats; smart00209"
                     /db_xref="CDD:214559"
     Region          592..631
                     /region_name="EGF_3"
                     /note="EGF domain; pfam12947"
                     /db_xref="CDD:463759"
     Region          633..668
                     /region_name="TSP3 repeat_1C"
                     /note="TSP3 repeat_1C [structural motif]"
                     /db_xref="CDD:275367"
     Region          705..727
                     /region_name="TSP3 repeat_short"
                     /note="TSP3 repeat_short [structural motif]"
                     /db_xref="CDD:275365"
     Region          728..763
                     /region_name="TSP_3"
                     /note="Thrombospondin type 3 repeat; pfam02412"
                     /db_xref="CDD:367074"
     Region          729..763
                     /region_name="TSP3 repeat_long"
                     /note="TSP3 repeat_long [structural motif]"
                     /db_xref="CDD:275366"
     Region          764..786
                     /region_name="TSP3 repeat_short"
                     /note="TSP3 repeat_short [structural motif]"
                     /db_xref="CDD:275366"
     Region          787..824
                     /region_name="TSP3 repeat_long"
                     /note="TSP3 repeat_long [structural motif]"
                     /db_xref="CDD:275365"
     Region          788..824
                     /region_name="TSP_3"
                     /note="Thrombospondin type 3 repeat; pfam02412"
                     /db_xref="CDD:367074"
     Region          825..860
                     /region_name="TSP3 repeat_short"
                     /note="TSP3 repeat_short [structural motif]"
                     /db_xref="CDD:275366"
     Region          861..894
                     /region_name="TSP_3"
                     /note="Thrombospondin type 3 repeat; pfam02412"
                     /db_xref="CDD:367074"
     Region          914..1111
                     /region_name="TSP_C"
                     /note="Thrombospondin C-terminal region; pfam05735"
                     /db_xref="CDD:461725"
     CDS             1..1112
                     /gene="THBS1"
                     /gene_synonym="THBS; THBS-1; TSP; TSP-1; TSP1"
                     /coded_by="XM_011521971.3:180..3518"
                     /db_xref="GeneID:7057"
                     /db_xref="HGNC:HGNC:11785"
                     /db_xref="MIM:188060"
ORIGIN      
        1 mglawglgvl flmhvcgtnr ipesggdnsv fdifeltgaa rkgsgrrlvk gpdpsspafr
       61 iedanlippv pddkfqdlvd avraekgfll laslrqmkkt rgtllalerk dhsgqvfsvv
      121 sngkagtldl sltvqgkqhv vsveeallat gqwksitlfv qedraqlyid cekmenaeld
      181 vpiqsvftrd lasiarlria kggvndnfqg vlqnvrfvfg ttpedilrnk gcssstsvll
      241 tldnnvvngs spairtnyig hktkdlqaic giscdelssm vlelrglrti vttlqdsirk
      301 vteenkelan elrrpplcyh ngvqyrnnee wtvdsctech cqnsvtickk vscpimpcsn
      361 atvpdgeccp rcwpsdsadd gwspwsewts cstscgngiq qrgrscdsln nrcegssvqt
      421 rtchiqecdk rfkqdggwsh wspwsscsvt cgdgvitrir lcnspspqmn gkpcegeare
      481 tkackkdacp ngclsnpcfa gvkctsypdg swkcgacppg ysgngiqctd vdeckevpda
      541 cfnhngehrc entdpgyncl pcpprftgsq pfgqgvehat ankqvckprn pctdgthdcn
      601 knakcnylgh ysdpmyrcec kpgyagngii cgedtdldgw pnenlvcvan atyhckkdnc
      661 pnlpnsgqed ydkdgigdac dddddndkip ddrdncpfhy npaqydydrd dvgdrcdncp
      721 ynhnpdqadt dnngegdaca adidgdgiln erdncqyvyn vdqrdtdmdg vgdqcdncpl
      781 ehnpdqldsd sdrigdtcdn nqdidedghq nnldncpyvp nanqadhdkd gkgdacdhdd
      841 dndgipddkd ncrlvpnpdq kdsdgdgrgd ackddfdhds vpdiddicpe nvdisetdfr
      901 rfqmipldpk gtsqndpnwv vrhqgkelvq tvncdpglav gydefnavdf sgtffinter
      961 dddyagfvfg yqsssrfyvv mwkqvtqsyw dtnptraqgy sglsvkvvns ttgpgehlrn
     1021 alwhtgntpg qvrtlwhdpr higwkdftay rwrlshrpkt gfirvvmyeg kkimadsgpi
     1081 ydktyaggrl glfvfsqemv ffsdlkyecr dp
//
LOCUS       XP_016878010            1878 aa            linear   PRI 05-AUG-2025
DEFINITION  tight junction protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_016878010
VERSION     XP_016878010.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022521.2
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 2% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1878
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1878
                     /product="tight junction protein 1 isoform X1"
                     /calculated_mol_wt=210287
     Region          115..201
                     /region_name="PDZ1_ZO1-like"
                     /note="PDZ domain 1 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; cd06727"
                     /db_xref="CDD:467209"
     Site            order(126..132,150,153,181,185,188..189)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467209"
     Region          279..356
                     /region_name="PDZ2_ZO1-like_ds"
                     /note="PDZ domain 2 of Zonula Occludens-1 (ZO-1), ZO-2 and
                     ZO-3, and related domains; form domain-swapping dimers;
                     cd06728"
                     /db_xref="CDD:467210"
     Site            order(279..284,289..305,308..310,313,315..316,323,
                     331..332,334..335,347..353)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:467210"
     Site            order(290..296,302,305,335,339,342..343)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467210"
     Region          515..594
                     /region_name="PDZ3_ZO1-like_domain"
                     /note="PDZ domain 3 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; cd06729"
                     /db_xref="CDD:467211"
     Site            order(525..531,541,544,573,577,580..581)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467211"
     Region          610..674
                     /region_name="SH3_ZO-1"
                     /note="Src homology 3 domain of the Tight junction
                     protein, Zonula occludens protein 1; cd12026"
                     /db_xref="CDD:212959"
     Site            order(610..612,640..642,647,650,669)
                     /site_type="other"
                     /note="PDZ interface"
                     /db_xref="CDD:212959"
     Site            order(612..618,631..632,635,650,658..659,667..669,
                     673..674)
                     /site_type="other"
                     /note="GuK interface [polypeptide binding]"
                     /db_xref="CDD:212959"
     Site            order(618,620,623,627,648..649,668,670..671)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212959"
     Region          708..887
                     /region_name="GuKc"
                     /note="Guanylate kinase homologues; smart00072"
                     /db_xref="CDD:214504"
     Region          <947..1342
                     /region_name="PHA03377"
                     /note="EBNA-3C; Provisional"
                     /db_xref="CDD:177614"
     Region          <1228..>1705
                     /region_name="PRK10263"
                     /note="DNA translocase FtsK; Provisional"
                     /db_xref="CDD:236669"
     Region          1746..1844
                     /region_name="ZU5"
                     /note="ZU5 domain; pfam00791"
                     /db_xref="CDD:459941"
     CDS             1..1878
                     /gene="TJP1"
                     /gene_synonym="ZO-1"
                     /coded_by="XM_017022521.2:211..5847"
                     /db_xref="GeneID:7082"
                     /db_xref="HGNC:HGNC:11827"
                     /db_xref="MIM:601009"
ORIGIN      
        1 mrrleglclr rrrrrrgpar ersgdkmkyq kyltvlqmai gvtpsnrgsl lplkrklwvt
       61 pssenpngat ssvsqgkpsl rrikgrlhrs ksldsmdfce ltstameeta iweqhtvtlh
      121 rapgfgfgia isggrdnphf qsgetsivis dvlkggpaeg qlqendrvam vngvsmdnve
      181 hafavqqlrk sgknakitir rkkkvqipvs rpdpepvsdn eedsydeeih dprsgrsgvv
      241 nrrsekiwpr drsasrersl sprsdrrsva ssqpakptkv tlvksrknee yglrlashif
      301 vkeisqdsla ardgniqegd vvlkingtvt enmsltdakt lierskgklk mvvqrderat
      361 llnvpdlsds ihsanaserd diseiqslas dhsgrshdrp prrsrsrspd qrsepsdhsr
      421 hspqqpsngs lrsrdeeris kpgavstpvk haddhtpktv eevtvernek qtpslpepkp
      481 vyaqvgqpdv dlpvspsdgv lpnsthedgi lrpsmklvkf rkgdsvglrl aggndvgifv
      541 agvledspaa kegleegdqi lrvnnvdftn iireeavlfl ldlpkgeevt ilaqkkkdvy
      601 rrivesdvgd sfyirthfey ekespyglsf nkgevfrvvd tlyngklgsw lairigknhk
      661 evergiipnk nraeqlasvq ytlpktaggd radfwrfrgl rsskrnlrks redlsaqpvq
      721 tkfpayervv lreagflrpv tifgpiadva reklareepd iyqiaksepr dagtdqrssg
      781 iirlhtikqi idqdkhalld vtpnavdrln yaqwypivvf lnpdskqgvk tmrmrlcpes
      841 rksarklyer shklrknnhh lftttinlns mndgwygalk eaiqqqqnql vwvsegkadg
      901 atsddldlhd drlsylsapg seysmystds rhtsdyedtd teggaytdqe ldetlndevg
      961 tppesaitrs sepvredssg mhhenqtypp yspqaqpqpi hridspgfkp asqqkaeass
     1021 pvpylspetn passtsavnh nvnltnvrle eptpapstsy spqadslrtp steaahimlr
     1081 dqepslsshv dptkvyrkdp ypeemmrqnh vlkqpavshp ghrpdkepnl tyepqlpyve
     1141 kqasrdleqp tyryesssyt dqfsrnyehr lryedrvpmy eeqwsyyddk qpypsrppfd
     1201 nqhsqdldsr qhpeesserg yfprfeepap lsydsrprye qaprasalrh eeqpapgydt
     1261 hgrlrpeaqp hpsagpkpae skqyfeqysr syeqvppqgf tsraghfepl hgaaavppli
     1321 pssqhkpeal psntkplppp ptqteeeedp amkpqsvltr vkmfenkrsa sletkkdvnd
     1381 tgsfkppeva skpsgapiig pkptsqnqfs ehdktlyrip epqkpqlkpp edivrsnhyd
     1441 peedeeyyrk qlsyfdrrsf enkppahiaa shlsepakpa hsqnqsnfss ysskflgsyt
     1501 sydylkrnvk wgkppeadgv drsfgekrye piqatppppp lpsqyaqpsq pvtsaslhih
     1561 skgahgegns vsldfqnslv skpdpppsqn kpatfrppnr edtaqaafyp qksfpdkapv
     1621 ngteqtqktv tpaynrftpk pytssarpfe rkfespkfnh nllpsetahk pdlssktpts
     1681 pktlvkshsl aqppefdsgv etfsihaekp kyqinnistv pkaipvspsa veedededgh
     1741 tvvatargif nsnggvlssi etgvsiiipq gaipegveqe iyfkvcrdns ilppldkekg
     1801 etllsplvmc gphglkflkp velrlphcas mtpdgwsfal kssdsssgdp ktwqnkclpg
     1861 dpnylvganc vsvlidhf
//
LOCUS       XP_016878011            1865 aa            linear   PRI 05-AUG-2025
DEFINITION  tight junction protein 1 isoform X2 [Homo sapiens].
ACCESSION   XP_016878011
VERSION     XP_016878011.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022522.2
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 2% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1865
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1865
                     /product="tight junction protein 1 isoform X2"
                     /calculated_mol_wt=208947
     Region          115..201
                     /region_name="PDZ1_ZO1-like"
                     /note="PDZ domain 1 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; cd06727"
                     /db_xref="CDD:467209"
     Site            order(126..132,150,153,181,185,188..189)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467209"
     Region          279..356
                     /region_name="PDZ2_ZO1-like_ds"
                     /note="PDZ domain 2 of Zonula Occludens-1 (ZO-1), ZO-2 and
                     ZO-3, and related domains; form domain-swapping dimers;
                     cd06728"
                     /db_xref="CDD:467210"
     Site            order(279..284,289..305,308..310,313,315..316,323,
                     331..332,334..335,347..353)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:467210"
     Site            order(290..296,302,305,335,339,342..343)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467210"
     Region          515..594
                     /region_name="PDZ3_ZO1-like_domain"
                     /note="PDZ domain 3 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; cd06729"
                     /db_xref="CDD:467211"
     Site            order(525..531,541,544,573,577,580..581)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467211"
     Region          610..674
                     /region_name="SH3_ZO-1"
                     /note="Src homology 3 domain of the Tight junction
                     protein, Zonula occludens protein 1; cd12026"
                     /db_xref="CDD:212959"
     Site            order(610..612,640..642,647,650,669)
                     /site_type="other"
                     /note="PDZ interface"
                     /db_xref="CDD:212959"
     Site            order(612..618,631..632,635,650,658..659,667..669,
                     673..674)
                     /site_type="other"
                     /note="GuK interface [polypeptide binding]"
                     /db_xref="CDD:212959"
     Site            order(618,620,623,627,648..649,668,670..671)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212959"
     Region          708..887
                     /region_name="GuKc"
                     /note="Guanylate kinase homologues; smart00072"
                     /db_xref="CDD:214504"
     Region          <947..1342
                     /region_name="PHA03377"
                     /note="EBNA-3C; Provisional"
                     /db_xref="CDD:177614"
     Region          <1228..>1705
                     /region_name="PRK10263"
                     /note="DNA translocase FtsK; Provisional"
                     /db_xref="CDD:236669"
     Region          1742..1855
                     /region_name="ZU5"
                     /note="Domain present in ZO-1 and Unc5-like netrin
                     receptors; smart00218"
                     /db_xref="CDD:128514"
     CDS             1..1865
                     /gene="TJP1"
                     /gene_synonym="ZO-1"
                     /coded_by="XM_017022522.2:211..5808"
                     /db_xref="GeneID:7082"
                     /db_xref="HGNC:HGNC:11827"
                     /db_xref="MIM:601009"
ORIGIN      
        1 mrrleglclr rrrrrrgpar ersgdkmkyq kyltvlqmai gvtpsnrgsl lplkrklwvt
       61 pssenpngat ssvsqgkpsl rrikgrlhrs ksldsmdfce ltstameeta iweqhtvtlh
      121 rapgfgfgia isggrdnphf qsgetsivis dvlkggpaeg qlqendrvam vngvsmdnve
      181 hafavqqlrk sgknakitir rkkkvqipvs rpdpepvsdn eedsydeeih dprsgrsgvv
      241 nrrsekiwpr drsasrersl sprsdrrsva ssqpakptkv tlvksrknee yglrlashif
      301 vkeisqdsla ardgniqegd vvlkingtvt enmsltdakt lierskgklk mvvqrderat
      361 llnvpdlsds ihsanaserd diseiqslas dhsgrshdrp prrsrsrspd qrsepsdhsr
      421 hspqqpsngs lrsrdeeris kpgavstpvk haddhtpktv eevtvernek qtpslpepkp
      481 vyaqvgqpdv dlpvspsdgv lpnsthedgi lrpsmklvkf rkgdsvglrl aggndvgifv
      541 agvledspaa kegleegdqi lrvnnvdftn iireeavlfl ldlpkgeevt ilaqkkkdvy
      601 rrivesdvgd sfyirthfey ekespyglsf nkgevfrvvd tlyngklgsw lairigknhk
      661 evergiipnk nraeqlasvq ytlpktaggd radfwrfrgl rsskrnlrks redlsaqpvq
      721 tkfpayervv lreagflrpv tifgpiadva reklareepd iyqiaksepr dagtdqrssg
      781 iirlhtikqi idqdkhalld vtpnavdrln yaqwypivvf lnpdskqgvk tmrmrlcpes
      841 rksarklyer shklrknnhh lftttinlns mndgwygalk eaiqqqqnql vwvsegkadg
      901 atsddldlhd drlsylsapg seysmystds rhtsdyedtd teggaytdqe ldetlndevg
      961 tppesaitrs sepvredssg mhhenqtypp yspqaqpqpi hridspgfkp asqqkaeass
     1021 pvpylspetn passtsavnh nvnltnvrle eptpapstsy spqadslrtp steaahimlr
     1081 dqepslsshv dptkvyrkdp ypeemmrqnh vlkqpavshp ghrpdkepnl tyepqlpyve
     1141 kqasrdleqp tyryesssyt dqfsrnyehr lryedrvpmy eeqwsyyddk qpypsrppfd
     1201 nqhsqdldsr qhpeesserg yfprfeepap lsydsrprye qaprasalrh eeqpapgydt
     1261 hgrlrpeaqp hpsagpkpae skqyfeqysr syeqvppqgf tsraghfepl hgaaavppli
     1321 pssqhkpeal psntkplppp ptqteeeedp amkpqsvltr vkmfenkrsa sletkkdvnd
     1381 tgsfkppeva skpsgapiig pkptsqnqfs ehdktlyrip epqkpqlkpp edivrsnhyd
     1441 peedeeyyrk qlsyfdrrsf enkppahiaa shlsepakpa hsqnqsnfss ysskflgsyt
     1501 sydylkrnvk wgkppeadgv drsfgekrye piqatppppp lpsqyaqpsq pvtsaslhih
     1561 skgahgegns vsldfqnslv skpdpppsqn kpatfrppnr edtaqaafyp qksfpdkapv
     1621 ngteqtqktv tpaynrftpk pytssarpfe rkfespkfnh nllpsetahk pdlssktpts
     1681 pktlvkshsl aqppefdsgv etfsihaekp kyqinnistv pkaipvspsa veedededgh
     1741 tvvatargif nsnggvlssi etgvsiiipq gaipegveqe iyfkvcrdns ilppldkekg
     1801 etllsplvmc gphglkflkp velrlphcas mtpdgdpktw qnkclpgdpn ylvgancvsv
     1861 lidhf
//
LOCUS       XP_016878012            1858 aa            linear   PRI 05-AUG-2025
DEFINITION  tight junction protein 1 isoform X3 [Homo sapiens].
ACCESSION   XP_016878012
VERSION     XP_016878012.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022523.2
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 2% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1858
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1858
                     /product="tight junction protein 1 isoform X3"
                     /calculated_mol_wt=208287
     Region          115..201
                     /region_name="PDZ1_ZO1-like"
                     /note="PDZ domain 1 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; cd06727"
                     /db_xref="CDD:467209"
     Site            order(126..132,150,153,181,185,188..189)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467209"
     Region          279..356
                     /region_name="PDZ2_ZO1-like_ds"
                     /note="PDZ domain 2 of Zonula Occludens-1 (ZO-1), ZO-2 and
                     ZO-3, and related domains; form domain-swapping dimers;
                     cd06728"
                     /db_xref="CDD:467210"
     Site            order(279..284,289..305,308..310,313,315..316,323,
                     331..332,334..335,347..353)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:467210"
     Site            order(290..296,302,305,335,339,342..343)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467210"
     Region          515..594
                     /region_name="PDZ3_ZO1-like_domain"
                     /note="PDZ domain 3 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; cd06729"
                     /db_xref="CDD:467211"
     Site            order(525..531,541,544,573,577,580..581)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467211"
     Region          610..674
                     /region_name="SH3_ZO-1"
                     /note="Src homology 3 domain of the Tight junction
                     protein, Zonula occludens protein 1; cd12026"
                     /db_xref="CDD:212959"
     Site            order(610..612,640..642,647,650,669)
                     /site_type="other"
                     /note="PDZ interface"
                     /db_xref="CDD:212959"
     Site            order(612..618,631..632,635,650,658..659,667..669,
                     673..674)
                     /site_type="other"
                     /note="GuK interface [polypeptide binding]"
                     /db_xref="CDD:212959"
     Site            order(618,620,623,627,648..649,668,670..671)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212959"
     Region          708..887
                     /region_name="GuKc"
                     /note="Guanylate kinase homologues; smart00072"
                     /db_xref="CDD:214504"
     Region          <947..1342
                     /region_name="PHA03377"
                     /note="EBNA-3C; Provisional"
                     /db_xref="CDD:177614"
     Region          <1228..>1705
                     /region_name="PRK10263"
                     /note="DNA translocase FtsK; Provisional"
                     /db_xref="CDD:236669"
     Region          1742..1848
                     /region_name="ZU5"
                     /note="Domain present in ZO-1 and Unc5-like netrin
                     receptors; smart00218"
                     /db_xref="CDD:128514"
     CDS             1..1858
                     /gene="TJP1"
                     /gene_synonym="ZO-1"
                     /coded_by="XM_017022523.2:211..5787"
                     /db_xref="GeneID:7082"
                     /db_xref="HGNC:HGNC:11827"
                     /db_xref="MIM:601009"
ORIGIN      
        1 mrrleglclr rrrrrrgpar ersgdkmkyq kyltvlqmai gvtpsnrgsl lplkrklwvt
       61 pssenpngat ssvsqgkpsl rrikgrlhrs ksldsmdfce ltstameeta iweqhtvtlh
      121 rapgfgfgia isggrdnphf qsgetsivis dvlkggpaeg qlqendrvam vngvsmdnve
      181 hafavqqlrk sgknakitir rkkkvqipvs rpdpepvsdn eedsydeeih dprsgrsgvv
      241 nrrsekiwpr drsasrersl sprsdrrsva ssqpakptkv tlvksrknee yglrlashif
      301 vkeisqdsla ardgniqegd vvlkingtvt enmsltdakt lierskgklk mvvqrderat
      361 llnvpdlsds ihsanaserd diseiqslas dhsgrshdrp prrsrsrspd qrsepsdhsr
      421 hspqqpsngs lrsrdeeris kpgavstpvk haddhtpktv eevtvernek qtpslpepkp
      481 vyaqvgqpdv dlpvspsdgv lpnsthedgi lrpsmklvkf rkgdsvglrl aggndvgifv
      541 agvledspaa kegleegdqi lrvnnvdftn iireeavlfl ldlpkgeevt ilaqkkkdvy
      601 rrivesdvgd sfyirthfey ekespyglsf nkgevfrvvd tlyngklgsw lairigknhk
      661 evergiipnk nraeqlasvq ytlpktaggd radfwrfrgl rsskrnlrks redlsaqpvq
      721 tkfpayervv lreagflrpv tifgpiadva reklareepd iyqiaksepr dagtdqrssg
      781 iirlhtikqi idqdkhalld vtpnavdrln yaqwypivvf lnpdskqgvk tmrmrlcpes
      841 rksarklyer shklrknnhh lftttinlns mndgwygalk eaiqqqqnql vwvsegkadg
      901 atsddldlhd drlsylsapg seysmystds rhtsdyedtd teggaytdqe ldetlndevg
      961 tppesaitrs sepvredssg mhhenqtypp yspqaqpqpi hridspgfkp asqqkaeass
     1021 pvpylspetn passtsavnh nvnltnvrle eptpapstsy spqadslrtp steaahimlr
     1081 dqepslsshv dptkvyrkdp ypeemmrqnh vlkqpavshp ghrpdkepnl tyepqlpyve
     1141 kqasrdleqp tyryesssyt dqfsrnyehr lryedrvpmy eeqwsyyddk qpypsrppfd
     1201 nqhsqdldsr qhpeesserg yfprfeepap lsydsrprye qaprasalrh eeqpapgydt
     1261 hgrlrpeaqp hpsagpkpae skqyfeqysr syeqvppqgf tsraghfepl hgaaavppli
     1321 pssqhkpeal psntkplppp ptqteeeedp amkpqsvltr vkmfenkrsa sletkkdvnd
     1381 tgsfkppeva skpsgapiig pkptsqnqfs ehdktlyrip epqkpqlkpp edivrsnhyd
     1441 peedeeyyrk qlsyfdrrsf enkppahiaa shlsepakpa hsqnqsnfss ysskflgsyt
     1501 sydylkrnvk wgkppeadgv drsfgekrye piqatppppp lpsqyaqpsq pvtsaslhih
     1561 skgahgegns vsldfqnslv skpdpppsqn kpatfrppnr edtaqaafyp qksfpdkapv
     1621 ngteqtqktv tpaynrftpk pytssarpfe rkfespkfnh nllpsetahk pdlssktpts
     1681 pktlvkshsl aqppefdsgv etfsihaekp kyqinnistv pkaipvspsa veedededgh
     1741 tvvatargif nsnggvlssi etgvsiiipq gaipegveqe iyfkvcrdns ilppldkekg
     1801 etllsplvmc gphglkflkp velrlphcdp ktwqnkclpg dpnylvganc vsvlidhf
//
LOCUS       XP_011520274            1848 aa            linear   PRI 05-AUG-2025
DEFINITION  tight junction protein 1 isoform X4 [Homo sapiens].
ACCESSION   XP_011520274
VERSION     XP_011520274.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521972.3
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Jun 6, 2016 this sequence version replaced XP_011520274.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 3% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1848
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1848
                     /product="tight junction protein 1 isoform X4"
                     /calculated_mol_wt=206824
     Region          115..201
                     /region_name="PDZ1_ZO1-like"
                     /note="PDZ domain 1 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; cd06727"
                     /db_xref="CDD:467209"
     Site            order(126..132,150,153,181,185,188..189)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467209"
     Region          279..356
                     /region_name="PDZ2_ZO1-like_ds"
                     /note="PDZ domain 2 of Zonula Occludens-1 (ZO-1), ZO-2 and
                     ZO-3, and related domains; form domain-swapping dimers;
                     cd06728"
                     /db_xref="CDD:467210"
     Site            order(279..284,289..305,308..310,313,315..316,323,
                     331..332,334..335,347..353)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:467210"
     Site            order(290..296,302,305,335,339,342..343)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467210"
     Region          515..594
                     /region_name="PDZ3_ZO1-like_domain"
                     /note="PDZ domain 3 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; cd06729"
                     /db_xref="CDD:467211"
     Site            order(525..531,541,544,573,577,580..581)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467211"
     Region          610..674
                     /region_name="SH3_ZO-1"
                     /note="Src homology 3 domain of the Tight junction
                     protein, Zonula occludens protein 1; cd12026"
                     /db_xref="CDD:212959"
     Site            order(610..612,640..642,647,650,669)
                     /site_type="other"
                     /note="PDZ interface"
                     /db_xref="CDD:212959"
     Site            order(612..618,631..632,635,650,658..659,667..669,
                     673..674)
                     /site_type="other"
                     /note="GuK interface [polypeptide binding]"
                     /db_xref="CDD:212959"
     Site            order(618,620,623,627,648..649,668,670..671)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212959"
     Region          708..887
                     /region_name="GuKc"
                     /note="Guanylate kinase homologues; smart00072"
                     /db_xref="CDD:214504"
     Region          <947..1342
                     /region_name="PHA03377"
                     /note="EBNA-3C; Provisional"
                     /db_xref="CDD:177614"
     Region          <1228..>1688
                     /region_name="PRK10263"
                     /note="DNA translocase FtsK; Provisional"
                     /db_xref="CDD:236669"
     Region          1725..1838
                     /region_name="ZU5"
                     /note="Domain present in ZO-1 and Unc5-like netrin
                     receptors; smart00218"
                     /db_xref="CDD:128514"
     CDS             1..1848
                     /gene="TJP1"
                     /gene_synonym="ZO-1"
                     /coded_by="XM_011521972.3:211..5757"
                     /db_xref="GeneID:7082"
                     /db_xref="HGNC:HGNC:11827"
                     /db_xref="MIM:601009"
ORIGIN      
        1 mrrleglclr rrrrrrgpar ersgdkmkyq kyltvlqmai gvtpsnrgsl lplkrklwvt
       61 pssenpngat ssvsqgkpsl rrikgrlhrs ksldsmdfce ltstameeta iweqhtvtlh
      121 rapgfgfgia isggrdnphf qsgetsivis dvlkggpaeg qlqendrvam vngvsmdnve
      181 hafavqqlrk sgknakitir rkkkvqipvs rpdpepvsdn eedsydeeih dprsgrsgvv
      241 nrrsekiwpr drsasrersl sprsdrrsva ssqpakptkv tlvksrknee yglrlashif
      301 vkeisqdsla ardgniqegd vvlkingtvt enmsltdakt lierskgklk mvvqrderat
      361 llnvpdlsds ihsanaserd diseiqslas dhsgrshdrp prrsrsrspd qrsepsdhsr
      421 hspqqpsngs lrsrdeeris kpgavstpvk haddhtpktv eevtvernek qtpslpepkp
      481 vyaqvgqpdv dlpvspsdgv lpnsthedgi lrpsmklvkf rkgdsvglrl aggndvgifv
      541 agvledspaa kegleegdqi lrvnnvdftn iireeavlfl ldlpkgeevt ilaqkkkdvy
      601 rrivesdvgd sfyirthfey ekespyglsf nkgevfrvvd tlyngklgsw lairigknhk
      661 evergiipnk nraeqlasvq ytlpktaggd radfwrfrgl rsskrnlrks redlsaqpvq
      721 tkfpayervv lreagflrpv tifgpiadva reklareepd iyqiaksepr dagtdqrssg
      781 iirlhtikqi idqdkhalld vtpnavdrln yaqwypivvf lnpdskqgvk tmrmrlcpes
      841 rksarklyer shklrknnhh lftttinlns mndgwygalk eaiqqqqnql vwvsegkadg
      901 atsddldlhd drlsylsapg seysmystds rhtsdyedtd teggaytdqe ldetlndevg
      961 tppesaitrs sepvredssg mhhenqtypp yspqaqpqpi hridspgfkp asqqkaeass
     1021 pvpylspetn passtsavnh nvnltnvrle eptpapstsy spqadslrtp steaahimlr
     1081 dqepslsshv dptkvyrkdp ypeemmrqnh vlkqpavshp ghrpdkepnl tyepqlpyve
     1141 kqasrdleqp tyryesssyt dqfsrnyehr lryedrvpmy eeqwsyyddk qpypsrppfd
     1201 nqhsqdldsr qhpeesserg yfprfeepap lsydsrprye qaprasalrh eeqpapgydt
     1261 hgrlrpeaqp hpsagpkpae skqyfeqysr syeqvppqgf tsraghfepl hgaaavppli
     1321 pssqhkpeal psntkplppp ptqteeeedp amkpqsvltr vkmfenkrsa sletkkdvnd
     1381 tgsfkppeva skpsgapiig pkptsqnqfs ehdktlyrip epqkpqlkpp edivrsnhyd
     1441 peedeeyyrk qlsyfdrrsf enkppahiaa shlsepakpa hsqnqsnfss ysskgkppea
     1501 dgvdrsfgek ryepiqatpp ppplpsqyaq psqpvtsasl hihskgahge gnsvsldfqn
     1561 slvskpdppp sqnkpatfrp pnredtaqaa fypqksfpdk apvngteqtq ktvtpaynrf
     1621 tpkpytssar pferkfespk fnhnllpset ahkpdlsskt ptspktlvks hslaqppefd
     1681 sgvetfsiha ekpkyqinni stvpkaipvs psaveedede dghtvvatar gifnsnggvl
     1741 ssietgvsii ipqgaipegv eqeiyfkvcr dnsilppldk ekgetllspl vmcgphglkf
     1801 lkpvelrlph casmtpdgdp ktwqnkclpg dpnylvganc vsvlidhf
//
LOCUS       XP_016878013            1798 aa            linear   PRI 05-AUG-2025
DEFINITION  tight junction protein 1 isoform X5 [Homo sapiens].
ACCESSION   XP_016878013
VERSION     XP_016878013.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022524.2
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 3% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1798
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1798
                     /product="tight junction protein 1 isoform X5"
                     /calculated_mol_wt=201794
     Region          115..201
                     /region_name="PDZ1_ZO1-like"
                     /note="PDZ domain 1 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; cd06727"
                     /db_xref="CDD:467209"
     Site            order(126..132,150,153,181,185,188..189)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467209"
     Region          279..356
                     /region_name="PDZ2_ZO1-like_ds"
                     /note="PDZ domain 2 of Zonula Occludens-1 (ZO-1), ZO-2 and
                     ZO-3, and related domains; form domain-swapping dimers;
                     cd06728"
                     /db_xref="CDD:467210"
     Site            order(279..284,289..305,308..310,313,315..316,323,
                     331..332,334..335,347..353)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:467210"
     Site            order(290..296,302,305,335,339,342..343)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467210"
     Region          515..594
                     /region_name="PDZ3_ZO1-like_domain"
                     /note="PDZ domain 3 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; cd06729"
                     /db_xref="CDD:467211"
     Site            order(525..531,541,544,573,577,580..581)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467211"
     Region          610..674
                     /region_name="SH3_ZO-1"
                     /note="Src homology 3 domain of the Tight junction
                     protein, Zonula occludens protein 1; cd12026"
                     /db_xref="CDD:212959"
     Site            order(610..612,640..642,647,650,669)
                     /site_type="other"
                     /note="PDZ interface"
                     /db_xref="CDD:212959"
     Site            order(612..618,631..632,635,650,658..659,667..669,
                     673..674)
                     /site_type="other"
                     /note="GuK interface [polypeptide binding]"
                     /db_xref="CDD:212959"
     Site            order(618,620,623,627,648..649,668,670..671)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212959"
     Region          708..887
                     /region_name="GuKc"
                     /note="Guanylate kinase homologues; smart00072"
                     /db_xref="CDD:214504"
     Region          <989..>1561
                     /region_name="PRK10263"
                     /note="DNA translocase FtsK; Provisional"
                     /db_xref="CDD:236669"
     Region          1666..1764
                     /region_name="ZU5"
                     /note="ZU5 domain; pfam00791"
                     /db_xref="CDD:459941"
     CDS             1..1798
                     /gene="TJP1"
                     /gene_synonym="ZO-1"
                     /coded_by="XM_017022524.2:211..5607"
                     /db_xref="GeneID:7082"
                     /db_xref="HGNC:HGNC:11827"
                     /db_xref="MIM:601009"
ORIGIN      
        1 mrrleglclr rrrrrrgpar ersgdkmkyq kyltvlqmai gvtpsnrgsl lplkrklwvt
       61 pssenpngat ssvsqgkpsl rrikgrlhrs ksldsmdfce ltstameeta iweqhtvtlh
      121 rapgfgfgia isggrdnphf qsgetsivis dvlkggpaeg qlqendrvam vngvsmdnve
      181 hafavqqlrk sgknakitir rkkkvqipvs rpdpepvsdn eedsydeeih dprsgrsgvv
      241 nrrsekiwpr drsasrersl sprsdrrsva ssqpakptkv tlvksrknee yglrlashif
      301 vkeisqdsla ardgniqegd vvlkingtvt enmsltdakt lierskgklk mvvqrderat
      361 llnvpdlsds ihsanaserd diseiqslas dhsgrshdrp prrsrsrspd qrsepsdhsr
      421 hspqqpsngs lrsrdeeris kpgavstpvk haddhtpktv eevtvernek qtpslpepkp
      481 vyaqvgqpdv dlpvspsdgv lpnsthedgi lrpsmklvkf rkgdsvglrl aggndvgifv
      541 agvledspaa kegleegdqi lrvnnvdftn iireeavlfl ldlpkgeevt ilaqkkkdvy
      601 rrivesdvgd sfyirthfey ekespyglsf nkgevfrvvd tlyngklgsw lairigknhk
      661 evergiipnk nraeqlasvq ytlpktaggd radfwrfrgl rsskrnlrks redlsaqpvq
      721 tkfpayervv lreagflrpv tifgpiadva reklareepd iyqiaksepr dagtdqrssg
      781 iirlhtikqi idqdkhalld vtpnavdrln yaqwypivvf lnpdskqgvk tmrmrlcpes
      841 rksarklyer shklrknnhh lftttinlns mndgwygalk eaiqqqqnql vwvsegkadg
      901 atsddldlhd drlsylsapg seysmystds rhtsdyedtd teggaytdqe ldetlndevg
      961 tppesaitrs sepvredssg mhhenqtypp yspqaqpqpi hridspgfkp asqqvyrkdp
     1021 ypeemmrqnh vlkqpavshp ghrpdkepnl tyepqlpyve kqasrdleqp tyryesssyt
     1081 dqfsrnyehr lryedrvpmy eeqwsyyddk qpypsrppfd nqhsqdldsr qhpeesserg
     1141 yfprfeepap lsydsrprye qaprasalrh eeqpapgydt hgrlrpeaqp hpsagpkpae
     1201 skqyfeqysr syeqvppqgf tsraghfepl hgaaavppli pssqhkpeal psntkplppp
     1261 ptqteeeedp amkpqsvltr vkmfenkrsa sletkkdvnd tgsfkppeva skpsgapiig
     1321 pkptsqnqfs ehdktlyrip epqkpqlkpp edivrsnhyd peedeeyyrk qlsyfdrrsf
     1381 enkppahiaa shlsepakpa hsqnqsnfss ysskflgsyt sydylkrnvk wgkppeadgv
     1441 drsfgekrye piqatppppp lpsqyaqpsq pvtsaslhih skgahgegns vsldfqnslv
     1501 skpdpppsqn kpatfrppnr edtaqaafyp qksfpdkapv ngteqtqktv tpaynrftpk
     1561 pytssarpfe rkfespkfnh nllpsetahk pdlssktpts pktlvkshsl aqppefdsgv
     1621 etfsihaekp kyqinnistv pkaipvspsa veedededgh tvvatargif nsnggvlssi
     1681 etgvsiiipq gaipegveqe iyfkvcrdns ilppldkekg etllsplvmc gphglkflkp
     1741 velrlphcas mtpdgwsfal kssdsssgdp ktwqnkclpg dpnylvganc vsvlidhf
//
LOCUS       XP_016878014            1789 aa            linear   PRI 05-AUG-2025
DEFINITION  tight junction protein 1 isoform X6 [Homo sapiens].
ACCESSION   XP_016878014
VERSION     XP_016878014.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022525.2
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 6% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1789
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1789
                     /product="tight junction protein 1 isoform X6"
                     /calculated_mol_wt=200161
     Region          26..112
                     /region_name="PDZ1_ZO1-like"
                     /note="PDZ domain 1 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; cd06727"
                     /db_xref="CDD:467209"
     Site            order(37..43,61,64,92,96,99..100)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467209"
     Region          190..267
                     /region_name="PDZ2_ZO1-like_ds"
                     /note="PDZ domain 2 of Zonula Occludens-1 (ZO-1), ZO-2 and
                     ZO-3, and related domains; form domain-swapping dimers;
                     cd06728"
                     /db_xref="CDD:467210"
     Site            order(190..195,200..216,219..221,224,226..227,234,
                     242..243,245..246,258..264)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:467210"
     Site            order(201..207,213,216,246,250,253..254)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467210"
     Region          426..505
                     /region_name="PDZ3_ZO1-like_domain"
                     /note="PDZ domain 3 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; cd06729"
                     /db_xref="CDD:467211"
     Site            order(436..442,452,455,484,488,491..492)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467211"
     Region          521..585
                     /region_name="SH3_ZO-1"
                     /note="Src homology 3 domain of the Tight junction
                     protein, Zonula occludens protein 1; cd12026"
                     /db_xref="CDD:212959"
     Site            order(521..523,551..553,558,561,580)
                     /site_type="other"
                     /note="PDZ interface"
                     /db_xref="CDD:212959"
     Site            order(523..529,542..543,546,561,569..570,578..580,
                     584..585)
                     /site_type="other"
                     /note="GuK interface [polypeptide binding]"
                     /db_xref="CDD:212959"
     Site            order(529,531,534,538,559..560,579,581..582)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212959"
     Region          619..798
                     /region_name="GuKc"
                     /note="Guanylate kinase homologues; smart00072"
                     /db_xref="CDD:214504"
     Region          <858..1253
                     /region_name="PHA03377"
                     /note="EBNA-3C; Provisional"
                     /db_xref="CDD:177614"
     Region          <1139..>1616
                     /region_name="PRK10263"
                     /note="DNA translocase FtsK; Provisional"
                     /db_xref="CDD:236669"
     Region          1657..1755
                     /region_name="ZU5"
                     /note="ZU5 domain; pfam00791"
                     /db_xref="CDD:459941"
     CDS             1..1789
                     /gene="TJP1"
                     /gene_synonym="ZO-1"
                     /coded_by="XM_017022525.2:577..5946"
                     /db_xref="GeneID:7082"
                     /db_xref="HGNC:HGNC:11827"
                     /db_xref="MIM:601009"
ORIGIN      
        1 merntfsmdc hskstameet aiweqhtvtl hrapgfgfgi aisggrdnph fqsgetsivi
       61 sdvlkggpae gqlqendrva mvngvsmdnv ehafavqqlr ksgknakiti rrkkkvqipv
      121 srpdpepvsd needsydeei hdprsgrsgv vnrrsekiwp rdrsasrers lsprsdrrsv
      181 assqpakptk vtlvksrkne eyglrlashi fvkeisqdsl aardgniqeg dvvlkingtv
      241 tenmsltdak tlierskgkl kmvvqrdera tllnvpdlsd sihsanaser ddiseiqsla
      301 sdhsgrshdr pprrsrsrsp dqrsepsdhs rhspqqpsng slrsrdeeri skpgavstpv
      361 khaddhtpkt veevtverne kqtpslpepk pvyaqvgqpd vdlpvspsdg vlpnsthedg
      421 ilrpsmklvk frkgdsvglr laggndvgif vagvledspa akegleegdq ilrvnnvdft
      481 niireeavlf lldlpkgeev tilaqkkkdv yrrivesdvg dsfyirthfe yekespygls
      541 fnkgevfrvv dtlyngklgs wlairigknh kevergiipn knraeqlasv qytlpktagg
      601 dradfwrfrg lrsskrnlrk sredlsaqpv qtkfpayerv vlreagflrp vtifgpiadv
      661 areklareep diyqiaksep rdagtdqrss giirlhtikq iidqdkhall dvtpnavdrl
      721 nyaqwypivv flnpdskqgv ktmrmrlcpe srksarklye rshklrknnh hlftttinln
      781 smndgwygal keaiqqqqnq lvwvsegkad gatsddldlh ddrlsylsap gseysmystd
      841 srhtsdyedt dteggaytdq eldetlndev gtppesaitr ssepvredss gmhhenqtyp
      901 pyspqaqpqp ihridspgfk pasqqkaeas spvpylspet npasstsavn hnvnltnvrl
      961 eeptpapsts yspqadslrt psteaahiml rdqepslssh vdptkvyrkd pypeemmrqn
     1021 hvlkqpavsh pghrpdkepn ltyepqlpyv ekqasrdleq ptyryesssy tdqfsrnyeh
     1081 rlryedrvpm yeeqwsyydd kqpypsrppf dnqhsqdlds rqhpeesser gyfprfeepa
     1141 plsydsrpry eqaprasalr heeqpapgyd thgrlrpeaq phpsagpkpa eskqyfeqys
     1201 rsyeqvppqg ftsraghfep lhgaaavppl ipssqhkpea lpsntkplpp pptqteeeed
     1261 pamkpqsvlt rvkmfenkrs asletkkdvn dtgsfkppev askpsgapii gpkptsqnqf
     1321 sehdktlyri pepqkpqlkp pedivrsnhy dpeedeeyyr kqlsyfdrrs fenkppahia
     1381 ashlsepakp ahsqnqsnfs sysskflgsy tsydylkrnv kwgkppeadg vdrsfgekry
     1441 epiqatpppp plpsqyaqps qpvtsaslhi hskgahgegn svsldfqnsl vskpdpppsq
     1501 nkpatfrppn redtaqaafy pqksfpdkap vngteqtqkt vtpaynrftp kpytssarpf
     1561 erkfespkfn hnllpsetah kpdlssktpt spktlvkshs laqppefdsg vetfsihaek
     1621 pkyqinnist vpkaipvsps aveedededg htvvatargi fnsnggvlss ietgvsiiip
     1681 qgaipegveq eiyfkvcrdn silppldkek getllsplvm cgphglkflk pvelrlphca
     1741 smtpdgwsfa lkssdsssgd pktwqnkclp gdpnylvgan cvsvlidhf
//
LOCUS       XP_016878015            1785 aa            linear   PRI 05-AUG-2025
DEFINITION  tight junction protein 1 isoform X7 [Homo sapiens].
ACCESSION   XP_016878015
VERSION     XP_016878015.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022526.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1785
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1785
                     /product="tight junction protein 1 isoform X7"
                     /calculated_mol_wt=199451
     Region          22..108
                     /region_name="PDZ1_ZO1-like"
                     /note="PDZ domain 1 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; cd06727"
                     /db_xref="CDD:467209"
     Site            order(33..39,57,60,88,92,95..96)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467209"
     Region          186..263
                     /region_name="PDZ2_ZO1-like_ds"
                     /note="PDZ domain 2 of Zonula Occludens-1 (ZO-1), ZO-2 and
                     ZO-3, and related domains; form domain-swapping dimers;
                     cd06728"
                     /db_xref="CDD:467210"
     Site            order(186..191,196..212,215..217,220,222..223,230,
                     238..239,241..242,254..260)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:467210"
     Site            order(197..203,209,212,242,246,249..250)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467210"
     Region          422..501
                     /region_name="PDZ3_ZO1-like_domain"
                     /note="PDZ domain 3 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; cd06729"
                     /db_xref="CDD:467211"
     Site            order(432..438,448,451,480,484,487..488)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467211"
     Region          517..581
                     /region_name="SH3_ZO-1"
                     /note="Src homology 3 domain of the Tight junction
                     protein, Zonula occludens protein 1; cd12026"
                     /db_xref="CDD:212959"
     Site            order(517..519,547..549,554,557,576)
                     /site_type="other"
                     /note="PDZ interface"
                     /db_xref="CDD:212959"
     Site            order(519..525,538..539,542,557,565..566,574..576,
                     580..581)
                     /site_type="other"
                     /note="GuK interface [polypeptide binding]"
                     /db_xref="CDD:212959"
     Site            order(525,527,530,534,555..556,575,577..578)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212959"
     Region          615..794
                     /region_name="GuKc"
                     /note="Guanylate kinase homologues; smart00072"
                     /db_xref="CDD:214504"
     Region          <854..1249
                     /region_name="PHA03377"
                     /note="EBNA-3C; Provisional"
                     /db_xref="CDD:177614"
     Region          <1135..>1612
                     /region_name="PRK10263"
                     /note="DNA translocase FtsK; Provisional"
                     /db_xref="CDD:236669"
     Region          1653..1751
                     /region_name="ZU5"
                     /note="ZU5 domain; pfam00791"
                     /db_xref="CDD:459941"
     CDS             1..1785
                     /gene="TJP1"
                     /gene_synonym="ZO-1"
                     /coded_by="XM_017022526.2:441..5798"
                     /db_xref="GeneID:7082"
                     /db_xref="HGNC:HGNC:11827"
                     /db_xref="MIM:601009"
ORIGIN      
        1 msaraaaaks tameetaiwe qhtvtlhrap gfgfgiaisg grdnphfqsg etsivisdvl
       61 kggpaegqlq endrvamvng vsmdnvehaf avqqlrksgk nakitirrkk kvqipvsrpd
      121 pepvsdneed sydeeihdpr sgrsgvvnrr sekiwprdrs asrerslspr sdrrsvassq
      181 pakptkvtlv ksrkneeygl rlashifvke isqdslaard gniqegdvvl kingtvtenm
      241 sltdaktlie rskgklkmvv qrderatlln vpdlsdsihs anaserddis eiqslasdhs
      301 grshdrpprr srsrspdqrs epsdhsrhsp qqpsngslrs rdeeriskpg avstpvkhad
      361 dhtpktveev tvernekqtp slpepkpvya qvgqpdvdlp vspsdgvlpn sthedgilrp
      421 smklvkfrkg dsvglrlagg ndvgifvagv ledspaakeg leegdqilrv nnvdftniir
      481 eeavlflldl pkgeevtila qkkkdvyrri vesdvgdsfy irthfeyeke spyglsfnkg
      541 evfrvvdtly ngklgswlai rigknhkeve rgiipnknra eqlasvqytl pktaggdrad
      601 fwrfrglrss krnlrksred lsaqpvqtkf payervvlre agflrpvtif gpiadvarek
      661 lareepdiyq iakseprdag tdqrssgiir lhtikqiidq dkhalldvtp navdrlnyaq
      721 wypivvflnp dskqgvktmr mrlcpesrks arklyershk lrknnhhlft ttinlnsmnd
      781 gwygalkeai qqqqnqlvwv segkadgats ddldlhddrl sylsapgsey smystdsrht
      841 sdyedtdteg gaytdqelde tlndevgtpp esaitrssep vredssgmhh enqtyppysp
      901 qaqpqpihri dspgfkpasq qkaeasspvp ylspetnpas stsavnhnvn ltnvrleept
      961 papstsyspq adslrtpste aahimlrdqe pslsshvdpt kvyrkdpype emmrqnhvlk
     1021 qpavshpghr pdkepnltye pqlpyvekqa srdleqptyr yesssytdqf srnyehrlry
     1081 edrvpmyeeq wsyyddkqpy psrppfdnqh sqdldsrqhp eessergyfp rfeepaplsy
     1141 dsrpryeqap rasalrheeq papgydthgr lrpeaqphps agpkpaeskq yfeqysrsye
     1201 qvppqgftsr aghfeplhga aavpplipss qhkpealpsn tkplpppptq teeeedpamk
     1261 pqsvltrvkm fenkrsasle tkkdvndtgs fkppevaskp sgapiigpkp tsqnqfsehd
     1321 ktlyripepq kpqlkppedi vrsnhydpee deeyyrkqls yfdrrsfenk ppahiaashl
     1381 sepakpahsq nqsnfssyss kflgsytsyd ylkrnvkwgk ppeadgvdrs fgekryepiq
     1441 atppppplps qyaqpsqpvt saslhihskg ahgegnsvsl dfqnslvskp dpppsqnkpa
     1501 tfrppnredt aqaafypqks fpdkapvngt eqtqktvtpa ynrftpkpyt ssarpferkf
     1561 espkfnhnll psetahkpdl ssktptspkt lvkshslaqp pefdsgvetf sihaekpkyq
     1621 innistvpka ipvspsavee dededghtvv atargifnsn ggvlssietg vsiiipqgai
     1681 pegveqeiyf kvcrdnsilp pldkekgetl lsplvmcgph glkflkpvel rlphcasmtp
     1741 dgwsfalkss dsssgdpktw qnkclpgdpn ylvgancvsv lidhf
//
LOCUS       XP_016878016            1783 aa            linear   PRI 05-AUG-2025
DEFINITION  tight junction protein 1 isoform X8 [Homo sapiens].
ACCESSION   XP_016878016
VERSION     XP_016878016.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022527.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1783
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1783
                     /product="tight junction protein 1 isoform X8"
                     /calculated_mol_wt=199552
     Region          20..106
                     /region_name="PDZ1_ZO1-like"
                     /note="PDZ domain 1 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; cd06727"
                     /db_xref="CDD:467209"
     Site            order(31..37,55,58,86,90,93..94)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467209"
     Region          184..261
                     /region_name="PDZ2_ZO1-like_ds"
                     /note="PDZ domain 2 of Zonula Occludens-1 (ZO-1), ZO-2 and
                     ZO-3, and related domains; form domain-swapping dimers;
                     cd06728"
                     /db_xref="CDD:467210"
     Site            order(184..189,194..210,213..215,218,220..221,228,
                     236..237,239..240,252..258)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:467210"
     Site            order(195..201,207,210,240,244,247..248)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467210"
     Region          420..499
                     /region_name="PDZ3_ZO1-like_domain"
                     /note="PDZ domain 3 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; cd06729"
                     /db_xref="CDD:467211"
     Site            order(430..436,446,449,478,482,485..486)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467211"
     Region          515..579
                     /region_name="SH3_ZO-1"
                     /note="Src homology 3 domain of the Tight junction
                     protein, Zonula occludens protein 1; cd12026"
                     /db_xref="CDD:212959"
     Site            order(515..517,545..547,552,555,574)
                     /site_type="other"
                     /note="PDZ interface"
                     /db_xref="CDD:212959"
     Site            order(517..523,536..537,540,555,563..564,572..574,
                     578..579)
                     /site_type="other"
                     /note="GuK interface [polypeptide binding]"
                     /db_xref="CDD:212959"
     Site            order(523,525,528,532,553..554,573,575..576)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212959"
     Region          613..792
                     /region_name="GuKc"
                     /note="Guanylate kinase homologues; smart00072"
                     /db_xref="CDD:214504"
     Region          <852..1247
                     /region_name="PHA03377"
                     /note="EBNA-3C; Provisional"
                     /db_xref="CDD:177614"
     Region          <1133..>1610
                     /region_name="PRK10263"
                     /note="DNA translocase FtsK; Provisional"
                     /db_xref="CDD:236669"
     Region          1651..1749
                     /region_name="ZU5"
                     /note="ZU5 domain; pfam00791"
                     /db_xref="CDD:459941"
     CDS             1..1783
                     /gene="TJP1"
                     /gene_synonym="ZO-1"
                     /coded_by="XM_017022527.2:44..5395"
                     /db_xref="GeneID:7082"
                     /db_xref="HGNC:HGNC:11827"
                     /db_xref="MIM:601009"
ORIGIN      
        1 mlyylfksta meetaiweqh tvtlhrapgf gfgiaisggr dnphfqsget sivisdvlkg
       61 gpaegqlqen drvamvngvs mdnvehafav qqlrksgkna kitirrkkkv qipvsrpdpe
      121 pvsdneedsy deeihdprsg rsgvvnrrse kiwprdrsas rerslsprsd rrsvassqpa
      181 kptkvtlvks rkneeyglrl ashifvkeis qdslaardgn iqegdvvlki ngtvtenmsl
      241 tdaktliers kgklkmvvqr deratllnvp dlsdsihsan aserddisei qslasdhsgr
      301 shdrpprrsr srspdqrsep sdhsrhspqq psngslrsrd eeriskpgav stpvkhaddh
      361 tpktveevtv ernekqtpsl pepkpvyaqv gqpdvdlpvs psdgvlpnst hedgilrpsm
      421 klvkfrkgds vglrlaggnd vgifvagvle dspaakegle egdqilrvnn vdftniiree
      481 avlflldlpk geevtilaqk kkdvyrrive sdvgdsfyir thfeyekesp yglsfnkgev
      541 frvvdtlyng klgswlairi gknhkeverg iipnknraeq lasvqytlpk taggdradfw
      601 rfrglrsskr nlrksredls aqpvqtkfpa yervvlreag flrpvtifgp iadvarekla
      661 reepdiyqia kseprdagtd qrssgiirlh tikqiidqdk halldvtpna vdrlnyaqwy
      721 pivvflnpds kqgvktmrmr lcpesrksar klyershklr knnhhlfttt inlnsmndgw
      781 ygalkeaiqq qqnqlvwvse gkadgatsdd ldlhddrlsy lsapgseysm ystdsrhtsd
      841 yedtdtegga ytdqeldetl ndevgtppes aitrssepvr edssgmhhen qtyppyspqa
      901 qpqpihrids pgfkpasqqk aeasspvpyl spetnpasst savnhnvnlt nvrleeptpa
      961 pstsyspqad slrtpsteaa himlrdqeps lsshvdptkv yrkdpypeem mrqnhvlkqp
     1021 avshpghrpd kepnltyepq lpyvekqasr dleqptyrye sssytdqfsr nyehrlryed
     1081 rvpmyeeqws yyddkqpyps rppfdnqhsq dldsrqhpee ssergyfprf eepaplsyds
     1141 rpryeqapra salrheeqpa pgydthgrlr peaqphpsag pkpaeskqyf eqysrsyeqv
     1201 ppqgftsrag hfeplhgaaa vpplipssqh kpealpsntk plpppptqte eeedpamkpq
     1261 svltrvkmfe nkrsasletk kdvndtgsfk ppevaskpsg apiigpkpts qnqfsehdkt
     1321 lyripepqkp qlkppedivr snhydpeede eyyrkqlsyf drrsfenkpp ahiaashlse
     1381 pakpahsqnq snfssysskf lgsytsydyl krnvkwgkpp eadgvdrsfg ekryepiqat
     1441 ppppplpsqy aqpsqpvtsa slhihskgah gegnsvsldf qnslvskpdp ppsqnkpatf
     1501 rppnredtaq aafypqksfp dkapvngteq tqktvtpayn rftpkpytss arpferkfes
     1561 pkfnhnllps etahkpdlss ktptspktlv kshslaqppe fdsgvetfsi haekpkyqin
     1621 nistvpkaip vspsaveede dedghtvvat argifnsngg vlssietgvs iiipqgaipe
     1681 gveqeiyfkv crdnsilppl dkekgetlls plvmcgphgl kflkpvelrl phcasmtpdg
     1741 wsfalkssds ssgdpktwqn kclpgdpnyl vgancvsvli dhf
//
LOCUS       XP_005254676            1781 aa            linear   PRI 05-AUG-2025
DEFINITION  tight junction protein 1 isoform X9 [Homo sapiens].
ACCESSION   XP_005254676
VERSION     XP_005254676.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254619.4
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Jun 6, 2016 this sequence version replaced XP_005254676.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 1% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1781
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1781
                     /product="tight junction protein 1 isoform X9"
                     /calculated_mol_wt=199671
     Region          115..201
                     /region_name="PDZ1_ZO1-like"
                     /note="PDZ domain 1 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; cd06727"
                     /db_xref="CDD:467209"
     Site            order(126..132,150,153,181,185,188..189)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467209"
     Region          279..356
                     /region_name="PDZ2_ZO1-like_ds"
                     /note="PDZ domain 2 of Zonula Occludens-1 (ZO-1), ZO-2 and
                     ZO-3, and related domains; form domain-swapping dimers;
                     cd06728"
                     /db_xref="CDD:467210"
     Site            order(279..284,289..305,308..310,313,315..316,323,
                     331..332,334..335,347..353)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:467210"
     Site            order(290..296,302,305,335,339,342..343)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467210"
     Region          515..594
                     /region_name="PDZ3_ZO1-like_domain"
                     /note="PDZ domain 3 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; cd06729"
                     /db_xref="CDD:467211"
     Site            order(525..531,541,544,573,577,580..581)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467211"
     Region          610..674
                     /region_name="SH3_ZO-1"
                     /note="Src homology 3 domain of the Tight junction
                     protein, Zonula occludens protein 1; cd12026"
                     /db_xref="CDD:212959"
     Site            order(610..612,640..642,647,650,669)
                     /site_type="other"
                     /note="PDZ interface"
                     /db_xref="CDD:212959"
     Site            order(612..618,631..632,635,650,658..659,667..669,
                     673..674)
                     /site_type="other"
                     /note="GuK interface [polypeptide binding]"
                     /db_xref="CDD:212959"
     Site            order(618,620,623,627,648..649,668,670..671)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212959"
     Region          708..887
                     /region_name="GuKc"
                     /note="Guanylate kinase homologues; smart00072"
                     /db_xref="CDD:214504"
     Region          <1148..>1608
                     /region_name="PRK10263"
                     /note="DNA translocase FtsK; Provisional"
                     /db_xref="CDD:236669"
     Region          1649..1747
                     /region_name="ZU5"
                     /note="ZU5 domain; pfam00791"
                     /db_xref="CDD:459941"
     CDS             1..1781
                     /gene="TJP1"
                     /gene_synonym="ZO-1"
                     /coded_by="XM_005254619.4:211..5556"
                     /db_xref="GeneID:7082"
                     /db_xref="HGNC:HGNC:11827"
                     /db_xref="MIM:601009"
ORIGIN      
        1 mrrleglclr rrrrrrgpar ersgdkmkyq kyltvlqmai gvtpsnrgsl lplkrklwvt
       61 pssenpngat ssvsqgkpsl rrikgrlhrs ksldsmdfce ltstameeta iweqhtvtlh
      121 rapgfgfgia isggrdnphf qsgetsivis dvlkggpaeg qlqendrvam vngvsmdnve
      181 hafavqqlrk sgknakitir rkkkvqipvs rpdpepvsdn eedsydeeih dprsgrsgvv
      241 nrrsekiwpr drsasrersl sprsdrrsva ssqpakptkv tlvksrknee yglrlashif
      301 vkeisqdsla ardgniqegd vvlkingtvt enmsltdakt lierskgklk mvvqrderat
      361 llnvpdlsds ihsanaserd diseiqslas dhsgrshdrp prrsrsrspd qrsepsdhsr
      421 hspqqpsngs lrsrdeeris kpgavstpvk haddhtpktv eevtvernek qtpslpepkp
      481 vyaqvgqpdv dlpvspsdgv lpnsthedgi lrpsmklvkf rkgdsvglrl aggndvgifv
      541 agvledspaa kegleegdqi lrvnnvdftn iireeavlfl ldlpkgeevt ilaqkkkdvy
      601 rrivesdvgd sfyirthfey ekespyglsf nkgevfrvvd tlyngklgsw lairigknhk
      661 evergiipnk nraeqlasvq ytlpktaggd radfwrfrgl rsskrnlrks redlsaqpvq
      721 tkfpayervv lreagflrpv tifgpiadva reklareepd iyqiaksepr dagtdqrssg
      781 iirlhtikqi idqdkhalld vtpnavdrln yaqwypivvf lnpdskqgvk tmrmrlcpes
      841 rksarklyer shklrknnhh lftttinlns mndgwygalk eaiqqqqnql vwvsegkadg
      901 atsddldlhd drlsylsapg seysmystds rhtsdyedtd teggaytdqe ldetlndevg
      961 tppesaitrs sepvredssg mhhenqtypp yspqaqpqpi hridspgfkp asqqvyrkdp
     1021 ypeemmrqnh vlkqpavshp ghrpdkepnl tyepqlpyve kqasrdleqp tyryesssyt
     1081 dqfsrnyehr lryedrvpmy eeqwsyyddk qpypsrppfd nqhsqdldsr qhpeesserg
     1141 yfprfeepap lsydsrprye qaprasalrh eeqpapgydt hgrlrpeaqp hpsagpkpae
     1201 skqyfeqysr syeqvppqgf tsraghfepl hgaaavppli pssqhkpeal psntkplppp
     1261 ptqteeeedp amkpqsvltr vkmfenkrsa sletkkdvnd tgsfkppeva skpsgapiig
     1321 pkptsqnqfs ehdktlyrip epqkpqlkpp edivrsnhyd peedeeyyrk qlsyfdrrsf
     1381 enkppahiaa shlsepakpa hsqnqsnfss ysskgkppea dgvdrsfgek ryepiqatpp
     1441 ppplpsqyaq psqpvtsasl hihskgahge gnsvsldfqn slvskpdppp sqnkpatfrp
     1501 pnredtaqaa fypqksfpdk apvngteqtq ktvtpaynrf tpkpytssar pferkfespk
     1561 fnhnllpset ahkpdlsskt ptspktlvks hslaqppefd sgvetfsiha ekpkyqinni
     1621 stvpkaipvs psaveedede dghtvvatar gifnsnggvl ssietgvsii ipqgaipegv
     1681 eqeiyfkvcr dnsilppldk ekgetllspl vmcgphglkf lkpvelrlph casmtpdgws
     1741 falkssdsss gdpktwqnkc lpgdpnylvg ancvsvlidh f
//
LOCUS       XP_047288937            1778 aa            linear   PRI 05-AUG-2025
DEFINITION  tight junction protein 1 isoform X10 [Homo sapiens].
ACCESSION   XP_047288937
VERSION     XP_047288937.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432981.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 3% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1778
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1778
                     /product="tight junction protein 1 isoform X10"
                     /calculated_mol_wt=199794
     Region          115..201
                     /region_name="PDZ1_ZO1-like"
                     /note="PDZ domain 1 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; cd06727"
                     /db_xref="CDD:467209"
     Site            order(126..132,150,153,181,185,188..189)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467209"
     Region          279..356
                     /region_name="PDZ2_ZO1-like_ds"
                     /note="PDZ domain 2 of Zonula Occludens-1 (ZO-1), ZO-2 and
                     ZO-3, and related domains; form domain-swapping dimers;
                     cd06728"
                     /db_xref="CDD:467210"
     Site            order(279..284,289..305,308..310,313,315..316,323,
                     331..332,334..335,347..353)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:467210"
     Site            order(290..296,302,305,335,339,342..343)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467210"
     Region          515..594
                     /region_name="PDZ3_ZO1-like_domain"
                     /note="PDZ domain 3 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; cd06729"
                     /db_xref="CDD:467211"
     Site            order(525..531,541,544,573,577,580..581)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467211"
     Region          610..674
                     /region_name="SH3_ZO-1"
                     /note="Src homology 3 domain of the Tight junction
                     protein, Zonula occludens protein 1; cd12026"
                     /db_xref="CDD:212959"
     Site            order(610..612,640..642,647,650,669)
                     /site_type="other"
                     /note="PDZ interface"
                     /db_xref="CDD:212959"
     Site            order(612..618,631..632,635,650,658..659,667..669,
                     673..674)
                     /site_type="other"
                     /note="GuK interface [polypeptide binding]"
                     /db_xref="CDD:212959"
     Site            order(618,620,623,627,648..649,668,670..671)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212959"
     Region          708..887
                     /region_name="GuKc"
                     /note="Guanylate kinase homologues; smart00072"
                     /db_xref="CDD:214504"
     Region          <989..>1561
                     /region_name="PRK10263"
                     /note="DNA translocase FtsK; Provisional"
                     /db_xref="CDD:236669"
     Region          1662..1768
                     /region_name="ZU5"
                     /note="Domain present in ZO-1 and Unc5-like netrin
                     receptors; smart00218"
                     /db_xref="CDD:128514"
     CDS             1..1778
                     /gene="TJP1"
                     /gene_synonym="ZO-1"
                     /coded_by="XM_047432981.1:211..5547"
                     /db_xref="GeneID:7082"
                     /db_xref="HGNC:HGNC:11827"
                     /db_xref="MIM:601009"
ORIGIN      
        1 mrrleglclr rrrrrrgpar ersgdkmkyq kyltvlqmai gvtpsnrgsl lplkrklwvt
       61 pssenpngat ssvsqgkpsl rrikgrlhrs ksldsmdfce ltstameeta iweqhtvtlh
      121 rapgfgfgia isggrdnphf qsgetsivis dvlkggpaeg qlqendrvam vngvsmdnve
      181 hafavqqlrk sgknakitir rkkkvqipvs rpdpepvsdn eedsydeeih dprsgrsgvv
      241 nrrsekiwpr drsasrersl sprsdrrsva ssqpakptkv tlvksrknee yglrlashif
      301 vkeisqdsla ardgniqegd vvlkingtvt enmsltdakt lierskgklk mvvqrderat
      361 llnvpdlsds ihsanaserd diseiqslas dhsgrshdrp prrsrsrspd qrsepsdhsr
      421 hspqqpsngs lrsrdeeris kpgavstpvk haddhtpktv eevtvernek qtpslpepkp
      481 vyaqvgqpdv dlpvspsdgv lpnsthedgi lrpsmklvkf rkgdsvglrl aggndvgifv
      541 agvledspaa kegleegdqi lrvnnvdftn iireeavlfl ldlpkgeevt ilaqkkkdvy
      601 rrivesdvgd sfyirthfey ekespyglsf nkgevfrvvd tlyngklgsw lairigknhk
      661 evergiipnk nraeqlasvq ytlpktaggd radfwrfrgl rsskrnlrks redlsaqpvq
      721 tkfpayervv lreagflrpv tifgpiadva reklareepd iyqiaksepr dagtdqrssg
      781 iirlhtikqi idqdkhalld vtpnavdrln yaqwypivvf lnpdskqgvk tmrmrlcpes
      841 rksarklyer shklrknnhh lftttinlns mndgwygalk eaiqqqqnql vwvsegkadg
      901 atsddldlhd drlsylsapg seysmystds rhtsdyedtd teggaytdqe ldetlndevg
      961 tppesaitrs sepvredssg mhhenqtypp yspqaqpqpi hridspgfkp asqqvyrkdp
     1021 ypeemmrqnh vlkqpavshp ghrpdkepnl tyepqlpyve kqasrdleqp tyryesssyt
     1081 dqfsrnyehr lryedrvpmy eeqwsyyddk qpypsrppfd nqhsqdldsr qhpeesserg
     1141 yfprfeepap lsydsrprye qaprasalrh eeqpapgydt hgrlrpeaqp hpsagpkpae
     1201 skqyfeqysr syeqvppqgf tsraghfepl hgaaavppli pssqhkpeal psntkplppp
     1261 ptqteeeedp amkpqsvltr vkmfenkrsa sletkkdvnd tgsfkppeva skpsgapiig
     1321 pkptsqnqfs ehdktlyrip epqkpqlkpp edivrsnhyd peedeeyyrk qlsyfdrrsf
     1381 enkppahiaa shlsepakpa hsqnqsnfss ysskflgsyt sydylkrnvk wgkppeadgv
     1441 drsfgekrye piqatppppp lpsqyaqpsq pvtsaslhih skgahgegns vsldfqnslv
     1501 skpdpppsqn kpatfrppnr edtaqaafyp qksfpdkapv ngteqtqktv tpaynrftpk
     1561 pytssarpfe rkfespkfnh nllpsetahk pdlssktpts pktlvkshsl aqppefdsgv
     1621 etfsihaekp kyqinnistv pkaipvspsa veedededgh tvvatargif nsnggvlssi
     1681 etgvsiiipq gaipegveqe iyfkvcrdns ilppldkekg etllsplvmc gphglkflkp
     1741 velrlphcdp ktwqnkclpg dpnylvganc vsvlidhf
//
LOCUS       XP_047288938            1773 aa            linear   PRI 05-AUG-2025
DEFINITION  tight junction protein 1 isoform X11 [Homo sapiens].
ACCESSION   XP_047288938
VERSION     XP_047288938.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432982.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1773
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1773
                     /product="tight junction protein 1 isoform X11"
                     /calculated_mol_wt=198334
     Region          10..96
                     /region_name="PDZ1_ZO1-like"
                     /note="PDZ domain 1 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; cd06727"
                     /db_xref="CDD:467209"
     Site            order(21..27,45,48,76,80,83..84)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467209"
     Region          174..251
                     /region_name="PDZ2_ZO1-like_ds"
                     /note="PDZ domain 2 of Zonula Occludens-1 (ZO-1), ZO-2 and
                     ZO-3, and related domains; form domain-swapping dimers;
                     cd06728"
                     /db_xref="CDD:467210"
     Site            order(174..179,184..200,203..205,208,210..211,218,
                     226..227,229..230,242..248)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:467210"
     Site            order(185..191,197,200,230,234,237..238)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467210"
     Region          410..489
                     /region_name="PDZ3_ZO1-like_domain"
                     /note="PDZ domain 3 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; cd06729"
                     /db_xref="CDD:467211"
     Site            order(420..426,436,439,468,472,475..476)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467211"
     Region          505..569
                     /region_name="SH3_ZO-1"
                     /note="Src homology 3 domain of the Tight junction
                     protein, Zonula occludens protein 1; cd12026"
                     /db_xref="CDD:212959"
     Site            order(505..507,535..537,542,545,564)
                     /site_type="other"
                     /note="PDZ interface"
                     /db_xref="CDD:212959"
     Site            order(507..513,526..527,530,545,553..554,562..564,
                     568..569)
                     /site_type="other"
                     /note="GuK interface [polypeptide binding]"
                     /db_xref="CDD:212959"
     Site            order(513,515,518,522,543..544,563,565..566)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212959"
     Region          603..782
                     /region_name="GuKc"
                     /note="Guanylate kinase homologues; smart00072"
                     /db_xref="CDD:214504"
     Region          <842..1237
                     /region_name="PHA03377"
                     /note="EBNA-3C; Provisional"
                     /db_xref="CDD:177614"
     Region          <1123..>1600
                     /region_name="PRK10263"
                     /note="DNA translocase FtsK; Provisional"
                     /db_xref="CDD:236669"
     Region          1641..1739
                     /region_name="ZU5"
                     /note="ZU5 domain; pfam00791"
                     /db_xref="CDD:459941"
     CDS             1..1773
                     /gene="TJP1"
                     /gene_synonym="ZO-1"
                     /coded_by="XM_047432982.1:96..5417"
                     /db_xref="GeneID:7082"
                     /db_xref="HGNC:HGNC:11827"
                     /db_xref="MIM:601009"
ORIGIN      
        1 meetaiweqh tvtlhrapgf gfgiaisggr dnphfqsget sivisdvlkg gpaegqlqen
       61 drvamvngvs mdnvehafav qqlrksgkna kitirrkkkv qipvsrpdpe pvsdneedsy
      121 deeihdprsg rsgvvnrrse kiwprdrsas rerslsprsd rrsvassqpa kptkvtlvks
      181 rkneeyglrl ashifvkeis qdslaardgn iqegdvvlki ngtvtenmsl tdaktliers
      241 kgklkmvvqr deratllnvp dlsdsihsan aserddisei qslasdhsgr shdrpprrsr
      301 srspdqrsep sdhsrhspqq psngslrsrd eeriskpgav stpvkhaddh tpktveevtv
      361 ernekqtpsl pepkpvyaqv gqpdvdlpvs psdgvlpnst hedgilrpsm klvkfrkgds
      421 vglrlaggnd vgifvagvle dspaakegle egdqilrvnn vdftniiree avlflldlpk
      481 geevtilaqk kkdvyrrive sdvgdsfyir thfeyekesp yglsfnkgev frvvdtlyng
      541 klgswlairi gknhkeverg iipnknraeq lasvqytlpk taggdradfw rfrglrsskr
      601 nlrksredls aqpvqtkfpa yervvlreag flrpvtifgp iadvarekla reepdiyqia
      661 kseprdagtd qrssgiirlh tikqiidqdk halldvtpna vdrlnyaqwy pivvflnpds
      721 kqgvktmrmr lcpesrksar klyershklr knnhhlfttt inlnsmndgw ygalkeaiqq
      781 qqnqlvwvse gkadgatsdd ldlhddrlsy lsapgseysm ystdsrhtsd yedtdtegga
      841 ytdqeldetl ndevgtppes aitrssepvr edssgmhhen qtyppyspqa qpqpihrids
      901 pgfkpasqqk aeasspvpyl spetnpasst savnhnvnlt nvrleeptpa pstsyspqad
      961 slrtpsteaa himlrdqeps lsshvdptkv yrkdpypeem mrqnhvlkqp avshpghrpd
     1021 kepnltyepq lpyvekqasr dleqptyrye sssytdqfsr nyehrlryed rvpmyeeqws
     1081 yyddkqpyps rppfdnqhsq dldsrqhpee ssergyfprf eepaplsyds rpryeqapra
     1141 salrheeqpa pgydthgrlr peaqphpsag pkpaeskqyf eqysrsyeqv ppqgftsrag
     1201 hfeplhgaaa vpplipssqh kpealpsntk plpppptqte eeedpamkpq svltrvkmfe
     1261 nkrsasletk kdvndtgsfk ppevaskpsg apiigpkpts qnqfsehdkt lyripepqkp
     1321 qlkppedivr snhydpeede eyyrkqlsyf drrsfenkpp ahiaashlse pakpahsqnq
     1381 snfssysskf lgsytsydyl krnvkwgkpp eadgvdrsfg ekryepiqat ppppplpsqy
     1441 aqpsqpvtsa slhihskgah gegnsvsldf qnslvskpdp ppsqnkpatf rppnredtaq
     1501 aafypqksfp dkapvngteq tqktvtpayn rftpkpytss arpferkfes pkfnhnllps
     1561 etahkpdlss ktptspktlv kshslaqppe fdsgvetfsi haekpkyqin nistvpkaip
     1621 vspsaveede dedghtvvat argifnsngg vlssietgvs iiipqgaipe gveqeiyfkv
     1681 crdnsilppl dkekgetlls plvmcgphgl kflkpvelrl phcasmtpdg wsfalkssds
     1741 ssgdpktwqn kclpgdpnyl vgancvsvli dhf
//
LOCUS       XP_047288939            1772 aa            linear   PRI 05-AUG-2025
DEFINITION  tight junction protein 1 isoform X12 [Homo sapiens].
ACCESSION   XP_047288939
VERSION     XP_047288939.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432983.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1772
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1772
                     /product="tight junction protein 1 isoform X12"
                     /calculated_mol_wt=198111
     Region          22..108
                     /region_name="PDZ1_ZO1-like"
                     /note="PDZ domain 1 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; cd06727"
                     /db_xref="CDD:467209"
     Site            order(33..39,57,60,88,92,95..96)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467209"
     Region          186..263
                     /region_name="PDZ2_ZO1-like_ds"
                     /note="PDZ domain 2 of Zonula Occludens-1 (ZO-1), ZO-2 and
                     ZO-3, and related domains; form domain-swapping dimers;
                     cd06728"
                     /db_xref="CDD:467210"
     Site            order(186..191,196..212,215..217,220,222..223,230,
                     238..239,241..242,254..260)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:467210"
     Site            order(197..203,209,212,242,246,249..250)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467210"
     Region          422..501
                     /region_name="PDZ3_ZO1-like_domain"
                     /note="PDZ domain 3 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; cd06729"
                     /db_xref="CDD:467211"
     Site            order(432..438,448,451,480,484,487..488)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467211"
     Region          517..581
                     /region_name="SH3_ZO-1"
                     /note="Src homology 3 domain of the Tight junction
                     protein, Zonula occludens protein 1; cd12026"
                     /db_xref="CDD:212959"
     Site            order(517..519,547..549,554,557,576)
                     /site_type="other"
                     /note="PDZ interface"
                     /db_xref="CDD:212959"
     Site            order(519..525,538..539,542,557,565..566,574..576,
                     580..581)
                     /site_type="other"
                     /note="GuK interface [polypeptide binding]"
                     /db_xref="CDD:212959"
     Site            order(525,527,530,534,555..556,575,577..578)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212959"
     Region          615..794
                     /region_name="GuKc"
                     /note="Guanylate kinase homologues; smart00072"
                     /db_xref="CDD:214504"
     Region          <854..1249
                     /region_name="PHA03377"
                     /note="EBNA-3C; Provisional"
                     /db_xref="CDD:177614"
     Region          <1135..>1612
                     /region_name="PRK10263"
                     /note="DNA translocase FtsK; Provisional"
                     /db_xref="CDD:236669"
     Region          1649..1762
                     /region_name="ZU5"
                     /note="Domain present in ZO-1 and Unc5-like netrin
                     receptors; smart00218"
                     /db_xref="CDD:128514"
     CDS             1..1772
                     /gene="TJP1"
                     /gene_synonym="ZO-1"
                     /coded_by="XM_047432983.1:441..5759"
                     /db_xref="GeneID:7082"
                     /db_xref="HGNC:HGNC:11827"
                     /db_xref="MIM:601009"
ORIGIN      
        1 msaraaaaks tameetaiwe qhtvtlhrap gfgfgiaisg grdnphfqsg etsivisdvl
       61 kggpaegqlq endrvamvng vsmdnvehaf avqqlrksgk nakitirrkk kvqipvsrpd
      121 pepvsdneed sydeeihdpr sgrsgvvnrr sekiwprdrs asrerslspr sdrrsvassq
      181 pakptkvtlv ksrkneeygl rlashifvke isqdslaard gniqegdvvl kingtvtenm
      241 sltdaktlie rskgklkmvv qrderatlln vpdlsdsihs anaserddis eiqslasdhs
      301 grshdrpprr srsrspdqrs epsdhsrhsp qqpsngslrs rdeeriskpg avstpvkhad
      361 dhtpktveev tvernekqtp slpepkpvya qvgqpdvdlp vspsdgvlpn sthedgilrp
      421 smklvkfrkg dsvglrlagg ndvgifvagv ledspaakeg leegdqilrv nnvdftniir
      481 eeavlflldl pkgeevtila qkkkdvyrri vesdvgdsfy irthfeyeke spyglsfnkg
      541 evfrvvdtly ngklgswlai rigknhkeve rgiipnknra eqlasvqytl pktaggdrad
      601 fwrfrglrss krnlrksred lsaqpvqtkf payervvlre agflrpvtif gpiadvarek
      661 lareepdiyq iakseprdag tdqrssgiir lhtikqiidq dkhalldvtp navdrlnyaq
      721 wypivvflnp dskqgvktmr mrlcpesrks arklyershk lrknnhhlft ttinlnsmnd
      781 gwygalkeai qqqqnqlvwv segkadgats ddldlhddrl sylsapgsey smystdsrht
      841 sdyedtdteg gaytdqelde tlndevgtpp esaitrssep vredssgmhh enqtyppysp
      901 qaqpqpihri dspgfkpasq qkaeasspvp ylspetnpas stsavnhnvn ltnvrleept
      961 papstsyspq adslrtpste aahimlrdqe pslsshvdpt kvyrkdpype emmrqnhvlk
     1021 qpavshpghr pdkepnltye pqlpyvekqa srdleqptyr yesssytdqf srnyehrlry
     1081 edrvpmyeeq wsyyddkqpy psrppfdnqh sqdldsrqhp eessergyfp rfeepaplsy
     1141 dsrpryeqap rasalrheeq papgydthgr lrpeaqphps agpkpaeskq yfeqysrsye
     1201 qvppqgftsr aghfeplhga aavpplipss qhkpealpsn tkplpppptq teeeedpamk
     1261 pqsvltrvkm fenkrsasle tkkdvndtgs fkppevaskp sgapiigpkp tsqnqfsehd
     1321 ktlyripepq kpqlkppedi vrsnhydpee deeyyrkqls yfdrrsfenk ppahiaashl
     1381 sepakpahsq nqsnfssyss kflgsytsyd ylkrnvkwgk ppeadgvdrs fgekryepiq
     1441 atppppplps qyaqpsqpvt saslhihskg ahgegnsvsl dfqnslvskp dpppsqnkpa
     1501 tfrppnredt aqaafypqks fpdkapvngt eqtqktvtpa ynrftpkpyt ssarpferkf
     1561 espkfnhnll psetahkpdl ssktptspkt lvkshslaqp pefdsgvetf sihaekpkyq
     1621 innistvpka ipvspsavee dededghtvv atargifnsn ggvlssietg vsiiipqgai
     1681 pegveqeiyf kvcrdnsilp pldkekgetl lsplvmcgph glkflkpvel rlphcasmtp
     1741 dgdpktwqnk clpgdpnylv gancvsvlid hf
//
LOCUS       XP_047288940            1768 aa            linear   PRI 05-AUG-2025
DEFINITION  tight junction protein 1 isoform X13 [Homo sapiens].
ACCESSION   XP_047288940
VERSION     XP_047288940.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432984.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 2% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1768
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1768
                     /product="tight junction protein 1 isoform X13"
                     /calculated_mol_wt=198331
     Region          115..201
                     /region_name="PDZ1_ZO1-like"
                     /note="PDZ domain 1 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; cd06727"
                     /db_xref="CDD:467209"
     Site            order(126..132,150,153,181,185,188..189)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467209"
     Region          279..356
                     /region_name="PDZ2_ZO1-like_ds"
                     /note="PDZ domain 2 of Zonula Occludens-1 (ZO-1), ZO-2 and
                     ZO-3, and related domains; form domain-swapping dimers;
                     cd06728"
                     /db_xref="CDD:467210"
     Site            order(279..284,289..305,308..310,313,315..316,323,
                     331..332,334..335,347..353)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:467210"
     Site            order(290..296,302,305,335,339,342..343)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467210"
     Region          515..594
                     /region_name="PDZ3_ZO1-like_domain"
                     /note="PDZ domain 3 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; cd06729"
                     /db_xref="CDD:467211"
     Site            order(525..531,541,544,573,577,580..581)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467211"
     Region          610..674
                     /region_name="SH3_ZO-1"
                     /note="Src homology 3 domain of the Tight junction
                     protein, Zonula occludens protein 1; cd12026"
                     /db_xref="CDD:212959"
     Site            order(610..612,640..642,647,650,669)
                     /site_type="other"
                     /note="PDZ interface"
                     /db_xref="CDD:212959"
     Site            order(612..618,631..632,635,650,658..659,667..669,
                     673..674)
                     /site_type="other"
                     /note="GuK interface [polypeptide binding]"
                     /db_xref="CDD:212959"
     Site            order(618,620,623,627,648..649,668,670..671)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212959"
     Region          708..887
                     /region_name="GuKc"
                     /note="Guanylate kinase homologues; smart00072"
                     /db_xref="CDD:214504"
     Region          <1148..>1608
                     /region_name="PRK10263"
                     /note="DNA translocase FtsK; Provisional"
                     /db_xref="CDD:236669"
     Region          1645..1758
                     /region_name="ZU5"
                     /note="Domain present in ZO-1 and Unc5-like netrin
                     receptors; smart00218"
                     /db_xref="CDD:128514"
     CDS             1..1768
                     /gene="TJP1"
                     /gene_synonym="ZO-1"
                     /coded_by="XM_047432984.1:211..5517"
                     /db_xref="GeneID:7082"
                     /db_xref="HGNC:HGNC:11827"
                     /db_xref="MIM:601009"
ORIGIN      
        1 mrrleglclr rrrrrrgpar ersgdkmkyq kyltvlqmai gvtpsnrgsl lplkrklwvt
       61 pssenpngat ssvsqgkpsl rrikgrlhrs ksldsmdfce ltstameeta iweqhtvtlh
      121 rapgfgfgia isggrdnphf qsgetsivis dvlkggpaeg qlqendrvam vngvsmdnve
      181 hafavqqlrk sgknakitir rkkkvqipvs rpdpepvsdn eedsydeeih dprsgrsgvv
      241 nrrsekiwpr drsasrersl sprsdrrsva ssqpakptkv tlvksrknee yglrlashif
      301 vkeisqdsla ardgniqegd vvlkingtvt enmsltdakt lierskgklk mvvqrderat
      361 llnvpdlsds ihsanaserd diseiqslas dhsgrshdrp prrsrsrspd qrsepsdhsr
      421 hspqqpsngs lrsrdeeris kpgavstpvk haddhtpktv eevtvernek qtpslpepkp
      481 vyaqvgqpdv dlpvspsdgv lpnsthedgi lrpsmklvkf rkgdsvglrl aggndvgifv
      541 agvledspaa kegleegdqi lrvnnvdftn iireeavlfl ldlpkgeevt ilaqkkkdvy
      601 rrivesdvgd sfyirthfey ekespyglsf nkgevfrvvd tlyngklgsw lairigknhk
      661 evergiipnk nraeqlasvq ytlpktaggd radfwrfrgl rsskrnlrks redlsaqpvq
      721 tkfpayervv lreagflrpv tifgpiadva reklareepd iyqiaksepr dagtdqrssg
      781 iirlhtikqi idqdkhalld vtpnavdrln yaqwypivvf lnpdskqgvk tmrmrlcpes
      841 rksarklyer shklrknnhh lftttinlns mndgwygalk eaiqqqqnql vwvsegkadg
      901 atsddldlhd drlsylsapg seysmystds rhtsdyedtd teggaytdqe ldetlndevg
      961 tppesaitrs sepvredssg mhhenqtypp yspqaqpqpi hridspgfkp asqqvyrkdp
     1021 ypeemmrqnh vlkqpavshp ghrpdkepnl tyepqlpyve kqasrdleqp tyryesssyt
     1081 dqfsrnyehr lryedrvpmy eeqwsyyddk qpypsrppfd nqhsqdldsr qhpeesserg
     1141 yfprfeepap lsydsrprye qaprasalrh eeqpapgydt hgrlrpeaqp hpsagpkpae
     1201 skqyfeqysr syeqvppqgf tsraghfepl hgaaavppli pssqhkpeal psntkplppp
     1261 ptqteeeedp amkpqsvltr vkmfenkrsa sletkkdvnd tgsfkppeva skpsgapiig
     1321 pkptsqnqfs ehdktlyrip epqkpqlkpp edivrsnhyd peedeeyyrk qlsyfdrrsf
     1381 enkppahiaa shlsepakpa hsqnqsnfss ysskgkppea dgvdrsfgek ryepiqatpp
     1441 ppplpsqyaq psqpvtsasl hihskgahge gnsvsldfqn slvskpdppp sqnkpatfrp
     1501 pnredtaqaa fypqksfpdk apvngteqtq ktvtpaynrf tpkpytssar pferkfespk
     1561 fnhnllpset ahkpdlsskt ptspktlvks hslaqppefd sgvetfsiha ekpkyqinni
     1621 stvpkaipvs psaveedede dghtvvatar gifnsnggvl ssietgvsii ipqgaipegv
     1681 eqeiyfkvcr dnsilppldk ekgetllspl vmcgphglkf lkpvelrlph casmtpdgdp
     1741 ktwqnkclpg dpnylvganc vsvlidhf
//
LOCUS       XP_005254677            1761 aa            linear   PRI 05-AUG-2025
DEFINITION  tight junction protein 1 isoform X14 [Homo sapiens].
ACCESSION   XP_005254677
VERSION     XP_005254677.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254620.4
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Jun 6, 2016 this sequence version replaced XP_005254677.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 2% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1761
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1761
                     /product="tight junction protein 1 isoform X14"
                     /calculated_mol_wt=197671
     Region          115..201
                     /region_name="PDZ1_ZO1-like"
                     /note="PDZ domain 1 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; cd06727"
                     /db_xref="CDD:467209"
     Site            order(126..132,150,153,181,185,188..189)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467209"
     Region          279..356
                     /region_name="PDZ2_ZO1-like_ds"
                     /note="PDZ domain 2 of Zonula Occludens-1 (ZO-1), ZO-2 and
                     ZO-3, and related domains; form domain-swapping dimers;
                     cd06728"
                     /db_xref="CDD:467210"
     Site            order(279..284,289..305,308..310,313,315..316,323,
                     331..332,334..335,347..353)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:467210"
     Site            order(290..296,302,305,335,339,342..343)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467210"
     Region          515..594
                     /region_name="PDZ3_ZO1-like_domain"
                     /note="PDZ domain 3 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; cd06729"
                     /db_xref="CDD:467211"
     Site            order(525..531,541,544,573,577,580..581)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467211"
     Region          610..674
                     /region_name="SH3_ZO-1"
                     /note="Src homology 3 domain of the Tight junction
                     protein, Zonula occludens protein 1; cd12026"
                     /db_xref="CDD:212959"
     Site            order(610..612,640..642,647,650,669)
                     /site_type="other"
                     /note="PDZ interface"
                     /db_xref="CDD:212959"
     Site            order(612..618,631..632,635,650,658..659,667..669,
                     673..674)
                     /site_type="other"
                     /note="GuK interface [polypeptide binding]"
                     /db_xref="CDD:212959"
     Site            order(618,620,623,627,648..649,668,670..671)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212959"
     Region          708..887
                     /region_name="GuKc"
                     /note="Guanylate kinase homologues; smart00072"
                     /db_xref="CDD:214504"
     Region          <1148..>1608
                     /region_name="PRK10263"
                     /note="DNA translocase FtsK; Provisional"
                     /db_xref="CDD:236669"
     Region          1645..1751
                     /region_name="ZU5"
                     /note="Domain present in ZO-1 and Unc5-like netrin
                     receptors; smart00218"
                     /db_xref="CDD:128514"
     CDS             1..1761
                     /gene="TJP1"
                     /gene_synonym="ZO-1"
                     /coded_by="XM_005254620.4:211..5496"
                     /db_xref="GeneID:7082"
                     /db_xref="HGNC:HGNC:11827"
                     /db_xref="MIM:601009"
ORIGIN      
        1 mrrleglclr rrrrrrgpar ersgdkmkyq kyltvlqmai gvtpsnrgsl lplkrklwvt
       61 pssenpngat ssvsqgkpsl rrikgrlhrs ksldsmdfce ltstameeta iweqhtvtlh
      121 rapgfgfgia isggrdnphf qsgetsivis dvlkggpaeg qlqendrvam vngvsmdnve
      181 hafavqqlrk sgknakitir rkkkvqipvs rpdpepvsdn eedsydeeih dprsgrsgvv
      241 nrrsekiwpr drsasrersl sprsdrrsva ssqpakptkv tlvksrknee yglrlashif
      301 vkeisqdsla ardgniqegd vvlkingtvt enmsltdakt lierskgklk mvvqrderat
      361 llnvpdlsds ihsanaserd diseiqslas dhsgrshdrp prrsrsrspd qrsepsdhsr
      421 hspqqpsngs lrsrdeeris kpgavstpvk haddhtpktv eevtvernek qtpslpepkp
      481 vyaqvgqpdv dlpvspsdgv lpnsthedgi lrpsmklvkf rkgdsvglrl aggndvgifv
      541 agvledspaa kegleegdqi lrvnnvdftn iireeavlfl ldlpkgeevt ilaqkkkdvy
      601 rrivesdvgd sfyirthfey ekespyglsf nkgevfrvvd tlyngklgsw lairigknhk
      661 evergiipnk nraeqlasvq ytlpktaggd radfwrfrgl rsskrnlrks redlsaqpvq
      721 tkfpayervv lreagflrpv tifgpiadva reklareepd iyqiaksepr dagtdqrssg
      781 iirlhtikqi idqdkhalld vtpnavdrln yaqwypivvf lnpdskqgvk tmrmrlcpes
      841 rksarklyer shklrknnhh lftttinlns mndgwygalk eaiqqqqnql vwvsegkadg
      901 atsddldlhd drlsylsapg seysmystds rhtsdyedtd teggaytdqe ldetlndevg
      961 tppesaitrs sepvredssg mhhenqtypp yspqaqpqpi hridspgfkp asqqvyrkdp
     1021 ypeemmrqnh vlkqpavshp ghrpdkepnl tyepqlpyve kqasrdleqp tyryesssyt
     1081 dqfsrnyehr lryedrvpmy eeqwsyyddk qpypsrppfd nqhsqdldsr qhpeesserg
     1141 yfprfeepap lsydsrprye qaprasalrh eeqpapgydt hgrlrpeaqp hpsagpkpae
     1201 skqyfeqysr syeqvppqgf tsraghfepl hgaaavppli pssqhkpeal psntkplppp
     1261 ptqteeeedp amkpqsvltr vkmfenkrsa sletkkdvnd tgsfkppeva skpsgapiig
     1321 pkptsqnqfs ehdktlyrip epqkpqlkpp edivrsnhyd peedeeyyrk qlsyfdrrsf
     1381 enkppahiaa shlsepakpa hsqnqsnfss ysskgkppea dgvdrsfgek ryepiqatpp
     1441 ppplpsqyaq psqpvtsasl hihskgahge gnsvsldfqn slvskpdppp sqnkpatfrp
     1501 pnredtaqaa fypqksfpdk apvngteqtq ktvtpaynrf tpkpytssar pferkfespk
     1561 fnhnllpset ahkpdlsskt ptspktlvks hslaqppefd sgvetfsiha ekpkyqinni
     1621 stvpkaipvs psaveedede dghtvvatar gifnsnggvl ssietgvsii ipqgaipegv
     1681 eqeiyfkvcr dnsilppldk ekgetllspl vmcgphglkf lkpvelrlph cdpktwqnkc
     1741 lpgdpnylvg ancvsvlidh f
//
LOCUS       XP_047288941            1759 aa            linear   PRI 05-AUG-2025
DEFINITION  tight junction protein 1 isoform X15 [Homo sapiens].
ACCESSION   XP_047288941
VERSION     XP_047288941.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432985.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 6% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1759
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1759
                     /product="tight junction protein 1 isoform X15"
                     /calculated_mol_wt=196698
     Region          26..112
                     /region_name="PDZ1_ZO1-like"
                     /note="PDZ domain 1 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; cd06727"
                     /db_xref="CDD:467209"
     Site            order(37..43,61,64,92,96,99..100)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467209"
     Region          190..267
                     /region_name="PDZ2_ZO1-like_ds"
                     /note="PDZ domain 2 of Zonula Occludens-1 (ZO-1), ZO-2 and
                     ZO-3, and related domains; form domain-swapping dimers;
                     cd06728"
                     /db_xref="CDD:467210"
     Site            order(190..195,200..216,219..221,224,226..227,234,
                     242..243,245..246,258..264)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:467210"
     Site            order(201..207,213,216,246,250,253..254)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467210"
     Region          426..505
                     /region_name="PDZ3_ZO1-like_domain"
                     /note="PDZ domain 3 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; cd06729"
                     /db_xref="CDD:467211"
     Site            order(436..442,452,455,484,488,491..492)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467211"
     Region          521..585
                     /region_name="SH3_ZO-1"
                     /note="Src homology 3 domain of the Tight junction
                     protein, Zonula occludens protein 1; cd12026"
                     /db_xref="CDD:212959"
     Site            order(521..523,551..553,558,561,580)
                     /site_type="other"
                     /note="PDZ interface"
                     /db_xref="CDD:212959"
     Site            order(523..529,542..543,546,561,569..570,578..580,
                     584..585)
                     /site_type="other"
                     /note="GuK interface [polypeptide binding]"
                     /db_xref="CDD:212959"
     Site            order(529,531,534,538,559..560,579,581..582)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212959"
     Region          619..798
                     /region_name="GuKc"
                     /note="Guanylate kinase homologues; smart00072"
                     /db_xref="CDD:214504"
     Region          <858..1253
                     /region_name="PHA03377"
                     /note="EBNA-3C; Provisional"
                     /db_xref="CDD:177614"
     Region          <1139..>1599
                     /region_name="PRK10263"
                     /note="DNA translocase FtsK; Provisional"
                     /db_xref="CDD:236669"
     Region          1636..1749
                     /region_name="ZU5"
                     /note="Domain present in ZO-1 and Unc5-like netrin
                     receptors; smart00218"
                     /db_xref="CDD:128514"
     CDS             1..1759
                     /gene="TJP1"
                     /gene_synonym="ZO-1"
                     /coded_by="XM_047432985.1:577..5856"
                     /db_xref="GeneID:7082"
                     /db_xref="HGNC:HGNC:11827"
                     /db_xref="MIM:601009"
ORIGIN      
        1 merntfsmdc hskstameet aiweqhtvtl hrapgfgfgi aisggrdnph fqsgetsivi
       61 sdvlkggpae gqlqendrva mvngvsmdnv ehafavqqlr ksgknakiti rrkkkvqipv
      121 srpdpepvsd needsydeei hdprsgrsgv vnrrsekiwp rdrsasrers lsprsdrrsv
      181 assqpakptk vtlvksrkne eyglrlashi fvkeisqdsl aardgniqeg dvvlkingtv
      241 tenmsltdak tlierskgkl kmvvqrdera tllnvpdlsd sihsanaser ddiseiqsla
      301 sdhsgrshdr pprrsrsrsp dqrsepsdhs rhspqqpsng slrsrdeeri skpgavstpv
      361 khaddhtpkt veevtverne kqtpslpepk pvyaqvgqpd vdlpvspsdg vlpnsthedg
      421 ilrpsmklvk frkgdsvglr laggndvgif vagvledspa akegleegdq ilrvnnvdft
      481 niireeavlf lldlpkgeev tilaqkkkdv yrrivesdvg dsfyirthfe yekespygls
      541 fnkgevfrvv dtlyngklgs wlairigknh kevergiipn knraeqlasv qytlpktagg
      601 dradfwrfrg lrsskrnlrk sredlsaqpv qtkfpayerv vlreagflrp vtifgpiadv
      661 areklareep diyqiaksep rdagtdqrss giirlhtikq iidqdkhall dvtpnavdrl
      721 nyaqwypivv flnpdskqgv ktmrmrlcpe srksarklye rshklrknnh hlftttinln
      781 smndgwygal keaiqqqqnq lvwvsegkad gatsddldlh ddrlsylsap gseysmystd
      841 srhtsdyedt dteggaytdq eldetlndev gtppesaitr ssepvredss gmhhenqtyp
      901 pyspqaqpqp ihridspgfk pasqqkaeas spvpylspet npasstsavn hnvnltnvrl
      961 eeptpapsts yspqadslrt psteaahiml rdqepslssh vdptkvyrkd pypeemmrqn
     1021 hvlkqpavsh pghrpdkepn ltyepqlpyv ekqasrdleq ptyryesssy tdqfsrnyeh
     1081 rlryedrvpm yeeqwsyydd kqpypsrppf dnqhsqdlds rqhpeesser gyfprfeepa
     1141 plsydsrpry eqaprasalr heeqpapgyd thgrlrpeaq phpsagpkpa eskqyfeqys
     1201 rsyeqvppqg ftsraghfep lhgaaavppl ipssqhkpea lpsntkplpp pptqteeeed
     1261 pamkpqsvlt rvkmfenkrs asletkkdvn dtgsfkppev askpsgapii gpkptsqnqf
     1321 sehdktlyri pepqkpqlkp pedivrsnhy dpeedeeyyr kqlsyfdrrs fenkppahia
     1381 ashlsepakp ahsqnqsnfs sysskgkppe adgvdrsfge kryepiqatp pppplpsqya
     1441 qpsqpvtsas lhihskgahg egnsvsldfq nslvskpdpp psqnkpatfr ppnredtaqa
     1501 afypqksfpd kapvngteqt qktvtpaynr ftpkpytssa rpferkfesp kfnhnllpse
     1561 tahkpdlssk tptspktlvk shslaqppef dsgvetfsih aekpkyqinn istvpkaipv
     1621 spsaveeded edghtvvata rgifnsnggv lssietgvsi iipqgaipeg veqeiyfkvc
     1681 rdnsilppld kekgetllsp lvmcgphglk flkpvelrlp hcasmtpdgd pktwqnkclp
     1741 gdpnylvgan cvsvlidhf
//
LOCUS       XP_047288942            1705 aa            linear   PRI 05-AUG-2025
DEFINITION  tight junction protein 1 isoform X16 [Homo sapiens].
ACCESSION   XP_047288942
VERSION     XP_047288942.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432986.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1705
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1705
                     /product="tight junction protein 1 isoform X16"
                     /calculated_mol_wt=190958
     Region          22..108
                     /region_name="PDZ1_ZO1-like"
                     /note="PDZ domain 1 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; cd06727"
                     /db_xref="CDD:467209"
     Site            order(33..39,57,60,88,92,95..96)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467209"
     Region          186..263
                     /region_name="PDZ2_ZO1-like_ds"
                     /note="PDZ domain 2 of Zonula Occludens-1 (ZO-1), ZO-2 and
                     ZO-3, and related domains; form domain-swapping dimers;
                     cd06728"
                     /db_xref="CDD:467210"
     Site            order(186..191,196..212,215..217,220,222..223,230,
                     238..239,241..242,254..260)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:467210"
     Site            order(197..203,209,212,242,246,249..250)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467210"
     Region          422..501
                     /region_name="PDZ3_ZO1-like_domain"
                     /note="PDZ domain 3 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; cd06729"
                     /db_xref="CDD:467211"
     Site            order(432..438,448,451,480,484,487..488)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467211"
     Region          517..581
                     /region_name="SH3_ZO-1"
                     /note="Src homology 3 domain of the Tight junction
                     protein, Zonula occludens protein 1; cd12026"
                     /db_xref="CDD:212959"
     Site            order(517..519,547..549,554,557,576)
                     /site_type="other"
                     /note="PDZ interface"
                     /db_xref="CDD:212959"
     Site            order(519..525,538..539,542,557,565..566,574..576,
                     580..581)
                     /site_type="other"
                     /note="GuK interface [polypeptide binding]"
                     /db_xref="CDD:212959"
     Site            order(525,527,530,534,555..556,575,577..578)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212959"
     Region          615..794
                     /region_name="GuKc"
                     /note="Guanylate kinase homologues; smart00072"
                     /db_xref="CDD:214504"
     Region          <896..>1468
                     /region_name="PRK10263"
                     /note="DNA translocase FtsK; Provisional"
                     /db_xref="CDD:236669"
     Region          1573..1671
                     /region_name="ZU5"
                     /note="ZU5 domain; pfam00791"
                     /db_xref="CDD:459941"
     CDS             1..1705
                     /gene="TJP1"
                     /gene_synonym="ZO-1"
                     /coded_by="XM_047432986.1:441..5558"
                     /db_xref="GeneID:7082"
                     /db_xref="HGNC:HGNC:11827"
                     /db_xref="MIM:601009"
ORIGIN      
        1 msaraaaaks tameetaiwe qhtvtlhrap gfgfgiaisg grdnphfqsg etsivisdvl
       61 kggpaegqlq endrvamvng vsmdnvehaf avqqlrksgk nakitirrkk kvqipvsrpd
      121 pepvsdneed sydeeihdpr sgrsgvvnrr sekiwprdrs asrerslspr sdrrsvassq
      181 pakptkvtlv ksrkneeygl rlashifvke isqdslaard gniqegdvvl kingtvtenm
      241 sltdaktlie rskgklkmvv qrderatlln vpdlsdsihs anaserddis eiqslasdhs
      301 grshdrpprr srsrspdqrs epsdhsrhsp qqpsngslrs rdeeriskpg avstpvkhad
      361 dhtpktveev tvernekqtp slpepkpvya qvgqpdvdlp vspsdgvlpn sthedgilrp
      421 smklvkfrkg dsvglrlagg ndvgifvagv ledspaakeg leegdqilrv nnvdftniir
      481 eeavlflldl pkgeevtila qkkkdvyrri vesdvgdsfy irthfeyeke spyglsfnkg
      541 evfrvvdtly ngklgswlai rigknhkeve rgiipnknra eqlasvqytl pktaggdrad
      601 fwrfrglrss krnlrksred lsaqpvqtkf payervvlre agflrpvtif gpiadvarek
      661 lareepdiyq iakseprdag tdqrssgiir lhtikqiidq dkhalldvtp navdrlnyaq
      721 wypivvflnp dskqgvktmr mrlcpesrks arklyershk lrknnhhlft ttinlnsmnd
      781 gwygalkeai qqqqnqlvwv segkadgats ddldlhddrl sylsapgsey smystdsrht
      841 sdyedtdteg gaytdqelde tlndevgtpp esaitrssep vredssgmhh enqtyppysp
      901 qaqpqpihri dspgfkpasq qvyrkdpype emmrqnhvlk qpavshpghr pdkepnltye
      961 pqlpyvekqa srdleqptyr yesssytdqf srnyehrlry edrvpmyeeq wsyyddkqpy
     1021 psrppfdnqh sqdldsrqhp eessergyfp rfeepaplsy dsrpryeqap rasalrheeq
     1081 papgydthgr lrpeaqphps agpkpaeskq yfeqysrsye qvppqgftsr aghfeplhga
     1141 aavpplipss qhkpealpsn tkplpppptq teeeedpamk pqsvltrvkm fenkrsasle
     1201 tkkdvndtgs fkppevaskp sgapiigpkp tsqnqfsehd ktlyripepq kpqlkppedi
     1261 vrsnhydpee deeyyrkqls yfdrrsfenk ppahiaashl sepakpahsq nqsnfssyss
     1321 kflgsytsyd ylkrnvkwgk ppeadgvdrs fgekryepiq atppppplps qyaqpsqpvt
     1381 saslhihskg ahgegnsvsl dfqnslvskp dpppsqnkpa tfrppnredt aqaafypqks
     1441 fpdkapvngt eqtqktvtpa ynrftpkpyt ssarpferkf espkfnhnll psetahkpdl
     1501 ssktptspkt lvkshslaqp pefdsgvetf sihaekpkyq innistvpka ipvspsavee
     1561 dededghtvv atargifnsn ggvlssietg vsiiipqgai pegveqeiyf kvcrdnsilp
     1621 pldkekgetl lsplvmcgph glkflkpvel rlphcasmtp dgwsfalkss dsssgdpktw
     1681 qnkclpgdpn ylvgancvsv lidhf
//
LOCUS       XP_047288943            1692 aa            linear   PRI 05-AUG-2025
DEFINITION  tight junction protein 1 isoform X17 [Homo sapiens].
ACCESSION   XP_047288943
VERSION     XP_047288943.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432987.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 6% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1692
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1692
                     /product="tight junction protein 1 isoform X17"
                     /calculated_mol_wt=189545
     Region          26..112
                     /region_name="PDZ1_ZO1-like"
                     /note="PDZ domain 1 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; cd06727"
                     /db_xref="CDD:467209"
     Site            order(37..43,61,64,92,96,99..100)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467209"
     Region          190..267
                     /region_name="PDZ2_ZO1-like_ds"
                     /note="PDZ domain 2 of Zonula Occludens-1 (ZO-1), ZO-2 and
                     ZO-3, and related domains; form domain-swapping dimers;
                     cd06728"
                     /db_xref="CDD:467210"
     Site            order(190..195,200..216,219..221,224,226..227,234,
                     242..243,245..246,258..264)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:467210"
     Site            order(201..207,213,216,246,250,253..254)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467210"
     Region          426..505
                     /region_name="PDZ3_ZO1-like_domain"
                     /note="PDZ domain 3 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; cd06729"
                     /db_xref="CDD:467211"
     Site            order(436..442,452,455,484,488,491..492)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467211"
     Region          521..585
                     /region_name="SH3_ZO-1"
                     /note="Src homology 3 domain of the Tight junction
                     protein, Zonula occludens protein 1; cd12026"
                     /db_xref="CDD:212959"
     Site            order(521..523,551..553,558,561,580)
                     /site_type="other"
                     /note="PDZ interface"
                     /db_xref="CDD:212959"
     Site            order(523..529,542..543,546,561,569..570,578..580,
                     584..585)
                     /site_type="other"
                     /note="GuK interface [polypeptide binding]"
                     /db_xref="CDD:212959"
     Site            order(529,531,534,538,559..560,579,581..582)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212959"
     Region          619..798
                     /region_name="GuKc"
                     /note="Guanylate kinase homologues; smart00072"
                     /db_xref="CDD:214504"
     Region          <1059..>1519
                     /region_name="PRK10263"
                     /note="DNA translocase FtsK; Provisional"
                     /db_xref="CDD:236669"
     Region          1560..1658
                     /region_name="ZU5"
                     /note="ZU5 domain; pfam00791"
                     /db_xref="CDD:459941"
     CDS             1..1692
                     /gene="TJP1"
                     /gene_synonym="ZO-1"
                     /coded_by="XM_047432987.1:577..5655"
                     /db_xref="GeneID:7082"
                     /db_xref="HGNC:HGNC:11827"
                     /db_xref="MIM:601009"
ORIGIN      
        1 merntfsmdc hskstameet aiweqhtvtl hrapgfgfgi aisggrdnph fqsgetsivi
       61 sdvlkggpae gqlqendrva mvngvsmdnv ehafavqqlr ksgknakiti rrkkkvqipv
      121 srpdpepvsd needsydeei hdprsgrsgv vnrrsekiwp rdrsasrers lsprsdrrsv
      181 assqpakptk vtlvksrkne eyglrlashi fvkeisqdsl aardgniqeg dvvlkingtv
      241 tenmsltdak tlierskgkl kmvvqrdera tllnvpdlsd sihsanaser ddiseiqsla
      301 sdhsgrshdr pprrsrsrsp dqrsepsdhs rhspqqpsng slrsrdeeri skpgavstpv
      361 khaddhtpkt veevtverne kqtpslpepk pvyaqvgqpd vdlpvspsdg vlpnsthedg
      421 ilrpsmklvk frkgdsvglr laggndvgif vagvledspa akegleegdq ilrvnnvdft
      481 niireeavlf lldlpkgeev tilaqkkkdv yrrivesdvg dsfyirthfe yekespygls
      541 fnkgevfrvv dtlyngklgs wlairigknh kevergiipn knraeqlasv qytlpktagg
      601 dradfwrfrg lrsskrnlrk sredlsaqpv qtkfpayerv vlreagflrp vtifgpiadv
      661 areklareep diyqiaksep rdagtdqrss giirlhtikq iidqdkhall dvtpnavdrl
      721 nyaqwypivv flnpdskqgv ktmrmrlcpe srksarklye rshklrknnh hlftttinln
      781 smndgwygal keaiqqqqnq lvwvsegkad gatsddldlh ddrlsylsap gseysmystd
      841 srhtsdyedt dteggaytdq eldetlndev gtppesaitr ssepvredss gmhhenqtyp
      901 pyspqaqpqp ihridspgfk pasqqvyrkd pypeemmrqn hvlkqpavsh pghrpdkepn
      961 ltyepqlpyv ekqasrdleq ptyryesssy tdqfsrnyeh rlryedrvpm yeeqwsyydd
     1021 kqpypsrppf dnqhsqdlds rqhpeesser gyfprfeepa plsydsrpry eqaprasalr
     1081 heeqpapgyd thgrlrpeaq phpsagpkpa eskqyfeqys rsyeqvppqg ftsraghfep
     1141 lhgaaavppl ipssqhkpea lpsntkplpp pptqteeeed pamkpqsvlt rvkmfenkrs
     1201 asletkkdvn dtgsfkppev askpsgapii gpkptsqnqf sehdktlyri pepqkpqlkp
     1261 pedivrsnhy dpeedeeyyr kqlsyfdrrs fenkppahia ashlsepakp ahsqnqsnfs
     1321 sysskgkppe adgvdrsfge kryepiqatp pppplpsqya qpsqpvtsas lhihskgahg
     1381 egnsvsldfq nslvskpdpp psqnkpatfr ppnredtaqa afypqksfpd kapvngteqt
     1441 qktvtpaynr ftpkpytssa rpferkfesp kfnhnllpse tahkpdlssk tptspktlvk
     1501 shslaqppef dsgvetfsih aekpkyqinn istvpkaipv spsaveeded edghtvvata
     1561 rgifnsnggv lssietgvsi iipqgaipeg veqeiyfkvc rdnsilppld kekgetllsp
     1621 lvmcgphglk flkpvelrlp hcasmtpdgw sfalkssdss sgdpktwqnk clpgdpnylv
     1681 gancvsvlid hf
//
LOCUS       XP_047288944            1692 aa            linear   PRI 05-AUG-2025
DEFINITION  tight junction protein 1 isoform X18 [Homo sapiens].
ACCESSION   XP_047288944
VERSION     XP_047288944.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432988.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1692
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1692
                     /product="tight junction protein 1 isoform X18"
                     /calculated_mol_wt=189618
     Region          22..108
                     /region_name="PDZ1_ZO1-like"
                     /note="PDZ domain 1 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; cd06727"
                     /db_xref="CDD:467209"
     Site            order(33..39,57,60,88,92,95..96)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467209"
     Region          186..263
                     /region_name="PDZ2_ZO1-like_ds"
                     /note="PDZ domain 2 of Zonula Occludens-1 (ZO-1), ZO-2 and
                     ZO-3, and related domains; form domain-swapping dimers;
                     cd06728"
                     /db_xref="CDD:467210"
     Site            order(186..191,196..212,215..217,220,222..223,230,
                     238..239,241..242,254..260)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:467210"
     Site            order(197..203,209,212,242,246,249..250)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467210"
     Region          422..501
                     /region_name="PDZ3_ZO1-like_domain"
                     /note="PDZ domain 3 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; cd06729"
                     /db_xref="CDD:467211"
     Site            order(432..438,448,451,480,484,487..488)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467211"
     Region          517..581
                     /region_name="SH3_ZO-1"
                     /note="Src homology 3 domain of the Tight junction
                     protein, Zonula occludens protein 1; cd12026"
                     /db_xref="CDD:212959"
     Site            order(517..519,547..549,554,557,576)
                     /site_type="other"
                     /note="PDZ interface"
                     /db_xref="CDD:212959"
     Site            order(519..525,538..539,542,557,565..566,574..576,
                     580..581)
                     /site_type="other"
                     /note="GuK interface [polypeptide binding]"
                     /db_xref="CDD:212959"
     Site            order(525,527,530,534,555..556,575,577..578)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212959"
     Region          615..794
                     /region_name="GuKc"
                     /note="Guanylate kinase homologues; smart00072"
                     /db_xref="CDD:214504"
     Region          <880..1306
                     /region_name="PTZ00449"
                     /note="104 kDa microneme/rhoptry antigen; Provisional"
                     /db_xref="CDD:185628"
     Region          1569..1682
                     /region_name="ZU5"
                     /note="Domain present in ZO-1 and Unc5-like netrin
                     receptors; smart00218"
                     /db_xref="CDD:128514"
     CDS             1..1692
                     /gene="TJP1"
                     /gene_synonym="ZO-1"
                     /coded_by="XM_047432988.1:441..5519"
                     /db_xref="GeneID:7082"
                     /db_xref="HGNC:HGNC:11827"
                     /db_xref="MIM:601009"
ORIGIN      
        1 msaraaaaks tameetaiwe qhtvtlhrap gfgfgiaisg grdnphfqsg etsivisdvl
       61 kggpaegqlq endrvamvng vsmdnvehaf avqqlrksgk nakitirrkk kvqipvsrpd
      121 pepvsdneed sydeeihdpr sgrsgvvnrr sekiwprdrs asrerslspr sdrrsvassq
      181 pakptkvtlv ksrkneeygl rlashifvke isqdslaard gniqegdvvl kingtvtenm
      241 sltdaktlie rskgklkmvv qrderatlln vpdlsdsihs anaserddis eiqslasdhs
      301 grshdrpprr srsrspdqrs epsdhsrhsp qqpsngslrs rdeeriskpg avstpvkhad
      361 dhtpktveev tvernekqtp slpepkpvya qvgqpdvdlp vspsdgvlpn sthedgilrp
      421 smklvkfrkg dsvglrlagg ndvgifvagv ledspaakeg leegdqilrv nnvdftniir
      481 eeavlflldl pkgeevtila qkkkdvyrri vesdvgdsfy irthfeyeke spyglsfnkg
      541 evfrvvdtly ngklgswlai rigknhkeve rgiipnknra eqlasvqytl pktaggdrad
      601 fwrfrglrss krnlrksred lsaqpvqtkf payervvlre agflrpvtif gpiadvarek
      661 lareepdiyq iakseprdag tdqrssgiir lhtikqiidq dkhalldvtp navdrlnyaq
      721 wypivvflnp dskqgvktmr mrlcpesrks arklyershk lrknnhhlft ttinlnsmnd
      781 gwygalkeai qqqqnqlvwv segkadgats ddldlhddrl sylsapgsey smystdsrht
      841 sdyedtdteg gaytdqelde tlndevgtpp esaitrssep vredssgmhh enqtyppysp
      901 qaqpqpihri dspgfkpasq qvyrkdpype emmrqnhvlk qpavshpghr pdkepnltye
      961 pqlpyvekqa srdleqptyr yesssytdqf srnyehrlry edrvpmyeeq wsyyddkqpy
     1021 psrppfdnqh sqdldsrqhp eessergyfp rfeepaplsy dsrpryeqap rasalrheeq
     1081 papgydthgr lrpeaqphps agpkpaeskq yfeqysrsye qvppqgftsr aghfeplhga
     1141 aavpplipss qhkpealpsn tkplpppptq teeeedpamk pqsvltrvkm fenkrsasle
     1201 tkkdvndtgs fkppevaskp sgapiigpkp tsqnqfsehd ktlyripepq kpqlkppedi
     1261 vrsnhydpee deeyyrkqls yfdrrsfenk ppahiaashl sepakpahsq nqsnfssyss
     1321 kflgsytsyd ylkrnvkwgk ppeadgvdrs fgekryepiq atppppplps qyaqpsqpvt
     1381 saslhihskg ahgegnsvsl dfqnslvskp dpppsqnkpa tfrppnredt aqaafypqks
     1441 fpdkapvngt eqtqktvtpa ynrftpkpyt ssarpferkf espkfnhnll psetahkpdl
     1501 ssktptspkt lvkshslaqp pefdsgvetf sihaekpkyq innistvpka ipvspsavee
     1561 dededghtvv atargifnsn ggvlssietg vsiiipqgai pegveqeiyf kvcrdnsilp
     1621 pldkekgetl lsplvmcgph glkflkpvel rlphcasmtp dgdpktwqnk clpgdpnylv
     1681 gancvsvlid hf
//
LOCUS       XP_047288945            1685 aa            linear   PRI 05-AUG-2025
DEFINITION  tight junction protein 1 isoform X19 [Homo sapiens].
ACCESSION   XP_047288945
VERSION     XP_047288945.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432989.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1685
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1685
                     /product="tight junction protein 1 isoform X19"
                     /calculated_mol_wt=188958
     Region          22..108
                     /region_name="PDZ1_ZO1-like"
                     /note="PDZ domain 1 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; cd06727"
                     /db_xref="CDD:467209"
     Site            order(33..39,57,60,88,92,95..96)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467209"
     Region          186..263
                     /region_name="PDZ2_ZO1-like_ds"
                     /note="PDZ domain 2 of Zonula Occludens-1 (ZO-1), ZO-2 and
                     ZO-3, and related domains; form domain-swapping dimers;
                     cd06728"
                     /db_xref="CDD:467210"
     Site            order(186..191,196..212,215..217,220,222..223,230,
                     238..239,241..242,254..260)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:467210"
     Site            order(197..203,209,212,242,246,249..250)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467210"
     Region          422..501
                     /region_name="PDZ3_ZO1-like_domain"
                     /note="PDZ domain 3 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; cd06729"
                     /db_xref="CDD:467211"
     Site            order(432..438,448,451,480,484,487..488)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467211"
     Region          517..581
                     /region_name="SH3_ZO-1"
                     /note="Src homology 3 domain of the Tight junction
                     protein, Zonula occludens protein 1; cd12026"
                     /db_xref="CDD:212959"
     Site            order(517..519,547..549,554,557,576)
                     /site_type="other"
                     /note="PDZ interface"
                     /db_xref="CDD:212959"
     Site            order(519..525,538..539,542,557,565..566,574..576,
                     580..581)
                     /site_type="other"
                     /note="GuK interface [polypeptide binding]"
                     /db_xref="CDD:212959"
     Site            order(525,527,530,534,555..556,575,577..578)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212959"
     Region          615..794
                     /region_name="GuKc"
                     /note="Guanylate kinase homologues; smart00072"
                     /db_xref="CDD:214504"
     Region          <896..>1468
                     /region_name="PRK10263"
                     /note="DNA translocase FtsK; Provisional"
                     /db_xref="CDD:236669"
     Region          1569..1675
                     /region_name="ZU5"
                     /note="Domain present in ZO-1 and Unc5-like netrin
                     receptors; smart00218"
                     /db_xref="CDD:128514"
     CDS             1..1685
                     /gene="TJP1"
                     /gene_synonym="ZO-1"
                     /coded_by="XM_047432989.1:441..5498"
                     /db_xref="GeneID:7082"
                     /db_xref="HGNC:HGNC:11827"
                     /db_xref="MIM:601009"
ORIGIN      
        1 msaraaaaks tameetaiwe qhtvtlhrap gfgfgiaisg grdnphfqsg etsivisdvl
       61 kggpaegqlq endrvamvng vsmdnvehaf avqqlrksgk nakitirrkk kvqipvsrpd
      121 pepvsdneed sydeeihdpr sgrsgvvnrr sekiwprdrs asrerslspr sdrrsvassq
      181 pakptkvtlv ksrkneeygl rlashifvke isqdslaard gniqegdvvl kingtvtenm
      241 sltdaktlie rskgklkmvv qrderatlln vpdlsdsihs anaserddis eiqslasdhs
      301 grshdrpprr srsrspdqrs epsdhsrhsp qqpsngslrs rdeeriskpg avstpvkhad
      361 dhtpktveev tvernekqtp slpepkpvya qvgqpdvdlp vspsdgvlpn sthedgilrp
      421 smklvkfrkg dsvglrlagg ndvgifvagv ledspaakeg leegdqilrv nnvdftniir
      481 eeavlflldl pkgeevtila qkkkdvyrri vesdvgdsfy irthfeyeke spyglsfnkg
      541 evfrvvdtly ngklgswlai rigknhkeve rgiipnknra eqlasvqytl pktaggdrad
      601 fwrfrglrss krnlrksred lsaqpvqtkf payervvlre agflrpvtif gpiadvarek
      661 lareepdiyq iakseprdag tdqrssgiir lhtikqiidq dkhalldvtp navdrlnyaq
      721 wypivvflnp dskqgvktmr mrlcpesrks arklyershk lrknnhhlft ttinlnsmnd
      781 gwygalkeai qqqqnqlvwv segkadgats ddldlhddrl sylsapgsey smystdsrht
      841 sdyedtdteg gaytdqelde tlndevgtpp esaitrssep vredssgmhh enqtyppysp
      901 qaqpqpihri dspgfkpasq qvyrkdpype emmrqnhvlk qpavshpghr pdkepnltye
      961 pqlpyvekqa srdleqptyr yesssytdqf srnyehrlry edrvpmyeeq wsyyddkqpy
     1021 psrppfdnqh sqdldsrqhp eessergyfp rfeepaplsy dsrpryeqap rasalrheeq
     1081 papgydthgr lrpeaqphps agpkpaeskq yfeqysrsye qvppqgftsr aghfeplhga
     1141 aavpplipss qhkpealpsn tkplpppptq teeeedpamk pqsvltrvkm fenkrsasle
     1201 tkkdvndtgs fkppevaskp sgapiigpkp tsqnqfsehd ktlyripepq kpqlkppedi
     1261 vrsnhydpee deeyyrkqls yfdrrsfenk ppahiaashl sepakpahsq nqsnfssyss
     1321 kflgsytsyd ylkrnvkwgk ppeadgvdrs fgekryepiq atppppplps qyaqpsqpvt
     1381 saslhihskg ahgegnsvsl dfqnslvskp dpppsqnkpa tfrppnredt aqaafypqks
     1441 fpdkapvngt eqtqktvtpa ynrftpkpyt ssarpferkf espkfnhnll psetahkpdl
     1501 ssktptspkt lvkshslaqp pefdsgvetf sihaekpkyq innistvpka ipvspsavee
     1561 dededghtvv atargifnsn ggvlssietg vsiiipqgai pegveqeiyf kvcrdnsilp
     1621 pldkekgetl lsplvmcgph glkflkpvel rlphcdpktw qnkclpgdpn ylvgancvsv
     1681 lidhf
//
LOCUS       XP_047288946            1675 aa            linear   PRI 05-AUG-2025
DEFINITION  tight junction protein 1 isoform X20 [Homo sapiens].
ACCESSION   XP_047288946
VERSION     XP_047288946.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432990.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1675
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1675
                     /product="tight junction protein 1 isoform X20"
                     /calculated_mol_wt=187495
     Region          22..108
                     /region_name="PDZ1_ZO1-like"
                     /note="PDZ domain 1 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; cd06727"
                     /db_xref="CDD:467209"
     Site            order(33..39,57,60,88,92,95..96)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467209"
     Region          186..263
                     /region_name="PDZ2_ZO1-like_ds"
                     /note="PDZ domain 2 of Zonula Occludens-1 (ZO-1), ZO-2 and
                     ZO-3, and related domains; form domain-swapping dimers;
                     cd06728"
                     /db_xref="CDD:467210"
     Site            order(186..191,196..212,215..217,220,222..223,230,
                     238..239,241..242,254..260)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:467210"
     Site            order(197..203,209,212,242,246,249..250)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467210"
     Region          422..501
                     /region_name="PDZ3_ZO1-like_domain"
                     /note="PDZ domain 3 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; cd06729"
                     /db_xref="CDD:467211"
     Site            order(432..438,448,451,480,484,487..488)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467211"
     Region          517..581
                     /region_name="SH3_ZO-1"
                     /note="Src homology 3 domain of the Tight junction
                     protein, Zonula occludens protein 1; cd12026"
                     /db_xref="CDD:212959"
     Site            order(517..519,547..549,554,557,576)
                     /site_type="other"
                     /note="PDZ interface"
                     /db_xref="CDD:212959"
     Site            order(519..525,538..539,542,557,565..566,574..576,
                     580..581)
                     /site_type="other"
                     /note="GuK interface [polypeptide binding]"
                     /db_xref="CDD:212959"
     Site            order(525,527,530,534,555..556,575,577..578)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212959"
     Region          615..794
                     /region_name="GuKc"
                     /note="Guanylate kinase homologues; smart00072"
                     /db_xref="CDD:214504"
     Region          <1055..>1515
                     /region_name="PRK10263"
                     /note="DNA translocase FtsK; Provisional"
                     /db_xref="CDD:236669"
     Region          1552..1665
                     /region_name="ZU5"
                     /note="Domain present in ZO-1 and Unc5-like netrin
                     receptors; smart00218"
                     /db_xref="CDD:128514"
     CDS             1..1675
                     /gene="TJP1"
                     /gene_synonym="ZO-1"
                     /coded_by="XM_047432990.1:441..5468"
                     /db_xref="GeneID:7082"
                     /db_xref="HGNC:HGNC:11827"
                     /db_xref="MIM:601009"
ORIGIN      
        1 msaraaaaks tameetaiwe qhtvtlhrap gfgfgiaisg grdnphfqsg etsivisdvl
       61 kggpaegqlq endrvamvng vsmdnvehaf avqqlrksgk nakitirrkk kvqipvsrpd
      121 pepvsdneed sydeeihdpr sgrsgvvnrr sekiwprdrs asrerslspr sdrrsvassq
      181 pakptkvtlv ksrkneeygl rlashifvke isqdslaard gniqegdvvl kingtvtenm
      241 sltdaktlie rskgklkmvv qrderatlln vpdlsdsihs anaserddis eiqslasdhs
      301 grshdrpprr srsrspdqrs epsdhsrhsp qqpsngslrs rdeeriskpg avstpvkhad
      361 dhtpktveev tvernekqtp slpepkpvya qvgqpdvdlp vspsdgvlpn sthedgilrp
      421 smklvkfrkg dsvglrlagg ndvgifvagv ledspaakeg leegdqilrv nnvdftniir
      481 eeavlflldl pkgeevtila qkkkdvyrri vesdvgdsfy irthfeyeke spyglsfnkg
      541 evfrvvdtly ngklgswlai rigknhkeve rgiipnknra eqlasvqytl pktaggdrad
      601 fwrfrglrss krnlrksred lsaqpvqtkf payervvlre agflrpvtif gpiadvarek
      661 lareepdiyq iakseprdag tdqrssgiir lhtikqiidq dkhalldvtp navdrlnyaq
      721 wypivvflnp dskqgvktmr mrlcpesrks arklyershk lrknnhhlft ttinlnsmnd
      781 gwygalkeai qqqqnqlvwv segkadgats ddldlhddrl sylsapgsey smystdsrht
      841 sdyedtdteg gaytdqelde tlndevgtpp esaitrssep vredssgmhh enqtyppysp
      901 qaqpqpihri dspgfkpasq qvyrkdpype emmrqnhvlk qpavshpghr pdkepnltye
      961 pqlpyvekqa srdleqptyr yesssytdqf srnyehrlry edrvpmyeeq wsyyddkqpy
     1021 psrppfdnqh sqdldsrqhp eessergyfp rfeepaplsy dsrpryeqap rasalrheeq
     1081 papgydthgr lrpeaqphps agpkpaeskq yfeqysrsye qvppqgftsr aghfeplhga
     1141 aavpplipss qhkpealpsn tkplpppptq teeeedpamk pqsvltrvkm fenkrsasle
     1201 tkkdvndtgs fkppevaskp sgapiigpkp tsqnqfsehd ktlyripepq kpqlkppedi
     1261 vrsnhydpee deeyyrkqls yfdrrsfenk ppahiaashl sepakpahsq nqsnfssyss
     1321 kgkppeadgv drsfgekrye piqatppppp lpsqyaqpsq pvtsaslhih skgahgegns
     1381 vsldfqnslv skpdpppsqn kpatfrppnr edtaqaafyp qksfpdkapv ngteqtqktv
     1441 tpaynrftpk pytssarpfe rkfespkfnh nllpsetahk pdlssktpts pktlvkshsl
     1501 aqppefdsgv etfsihaekp kyqinnistv pkaipvspsa veedededgh tvvatargif
     1561 nsnggvlssi etgvsiiipq gaipegveqe iyfkvcrdns ilppldkekg etllsplvmc
     1621 gphglkflkp velrlphcas mtpdgdpktw qnkclpgdpn ylvgancvsv lidhf
//
LOCUS       XP_047288947            1666 aa            linear   PRI 05-AUG-2025
DEFINITION  tight junction protein 1 isoform X21 [Homo sapiens].
ACCESSION   XP_047288947
VERSION     XP_047288947.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432991.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1666
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1666
                     /product="tight junction protein 1 isoform X21"
                     /calculated_mol_wt=186937
     Region          20..106
                     /region_name="PDZ1_ZO1-like"
                     /note="PDZ domain 1 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; cd06727"
                     /db_xref="CDD:467209"
     Site            order(31..37,55,58,86,90,93..94)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467209"
     Region          184..261
                     /region_name="PDZ2_ZO1-like_ds"
                     /note="PDZ domain 2 of Zonula Occludens-1 (ZO-1), ZO-2 and
                     ZO-3, and related domains; form domain-swapping dimers;
                     cd06728"
                     /db_xref="CDD:467210"
     Site            order(184..189,194..210,213..215,218,220..221,228,
                     236..237,239..240,252..258)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:467210"
     Site            order(195..201,207,210,240,244,247..248)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467210"
     Region          420..499
                     /region_name="PDZ3_ZO1-like_domain"
                     /note="PDZ domain 3 of Zonula Occludens-1 (ZO-1), homologs
                     ZO-2 and ZO-3, and related domains; cd06729"
                     /db_xref="CDD:467211"
     Site            order(430..436,446,449,478,482,485..486)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467211"
     Region          515..579
                     /region_name="SH3_ZO-1"
                     /note="Src homology 3 domain of the Tight junction
                     protein, Zonula occludens protein 1; cd12026"
                     /db_xref="CDD:212959"
     Site            order(515..517,545..547,552,555,574)
                     /site_type="other"
                     /note="PDZ interface"
                     /db_xref="CDD:212959"
     Site            order(517..523,536..537,540,555,563..564,572..574,
                     578..579)
                     /site_type="other"
                     /note="GuK interface [polypeptide binding]"
                     /db_xref="CDD:212959"
     Site            order(523,525,528,532,553..554,573,575..576)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212959"
     Region          613..792
                     /region_name="GuKc"
                     /note="Guanylate kinase homologues; smart00072"
                     /db_xref="CDD:214504"
     Region          <1053..>1513
                     /region_name="PRK10263"
                     /note="DNA translocase FtsK; Provisional"
                     /db_xref="CDD:236669"
     Region          1550..1656
                     /region_name="ZU5"
                     /note="Domain present in ZO-1 and Unc5-like netrin
                     receptors; smart00218"
                     /db_xref="CDD:128514"
     CDS             1..1666
                     /gene="TJP1"
                     /gene_synonym="ZO-1"
                     /coded_by="XM_047432991.1:44..5044"
                     /db_xref="GeneID:7082"
                     /db_xref="HGNC:HGNC:11827"
                     /db_xref="MIM:601009"
ORIGIN      
        1 mlyylfksta meetaiweqh tvtlhrapgf gfgiaisggr dnphfqsget sivisdvlkg
       61 gpaegqlqen drvamvngvs mdnvehafav qqlrksgkna kitirrkkkv qipvsrpdpe
      121 pvsdneedsy deeihdprsg rsgvvnrrse kiwprdrsas rerslsprsd rrsvassqpa
      181 kptkvtlvks rkneeyglrl ashifvkeis qdslaardgn iqegdvvlki ngtvtenmsl
      241 tdaktliers kgklkmvvqr deratllnvp dlsdsihsan aserddisei qslasdhsgr
      301 shdrpprrsr srspdqrsep sdhsrhspqq psngslrsrd eeriskpgav stpvkhaddh
      361 tpktveevtv ernekqtpsl pepkpvyaqv gqpdvdlpvs psdgvlpnst hedgilrpsm
      421 klvkfrkgds vglrlaggnd vgifvagvle dspaakegle egdqilrvnn vdftniiree
      481 avlflldlpk geevtilaqk kkdvyrrive sdvgdsfyir thfeyekesp yglsfnkgev
      541 frvvdtlyng klgswlairi gknhkeverg iipnknraeq lasvqytlpk taggdradfw
      601 rfrglrsskr nlrksredls aqpvqtkfpa yervvlreag flrpvtifgp iadvarekla
      661 reepdiyqia kseprdagtd qrssgiirlh tikqiidqdk halldvtpna vdrlnyaqwy
      721 pivvflnpds kqgvktmrmr lcpesrksar klyershklr knnhhlfttt inlnsmndgw
      781 ygalkeaiqq qqnqlvwvse gkadgatsdd ldlhddrlsy lsapgseysm ystdsrhtsd
      841 yedtdtegga ytdqeldetl ndevgtppes aitrssepvr edssgmhhen qtyppyspqa
      901 qpqpihrids pgfkpasqqv yrkdpypeem mrqnhvlkqp avshpghrpd kepnltyepq
      961 lpyvekqasr dleqptyrye sssytdqfsr nyehrlryed rvpmyeeqws yyddkqpyps
     1021 rppfdnqhsq dldsrqhpee ssergyfprf eepaplsyds rpryeqapra salrheeqpa
     1081 pgydthgrlr peaqphpsag pkpaeskqyf eqysrsyeqv ppqgftsrag hfeplhgaaa
     1141 vpplipssqh kpealpsntk plpppptqte eeedpamkpq svltrvkmfe nkrsasletk
     1201 kdvndtgsfk ppevaskpsg apiigpkpts qnqfsehdkt lyripepqkp qlkppedivr
     1261 snhydpeede eyyrkqlsyf drrsfenkpp ahiaashlse pakpahsqnq snfssysskg
     1321 kppeadgvdr sfgekryepi qatppppplp sqyaqpsqpv tsaslhihsk gahgegnsvs
     1381 ldfqnslvsk pdpppsqnkp atfrppnred taqaafypqk sfpdkapvng teqtqktvtp
     1441 aynrftpkpy tssarpferk fespkfnhnl lpsetahkpd lssktptspk tlvkshslaq
     1501 ppefdsgvet fsihaekpky qinnistvpk aipvspsave edededghtv vatargifns
     1561 nggvlssiet gvsiiipqga ipegveqeiy fkvcrdnsil ppldkekget llsplvmcgp
     1621 hglkflkpve lrlphcdpkt wqnkclpgdp nylvgancvs vlidhf
//
LOCUS       XP_011520278             782 aa            linear   PRI 05-AUG-2025
DEFINITION  transducin-like enhancer protein 3 isoform X1 [Homo sapiens].
ACCESSION   XP_011520278
VERSION     XP_011520278.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521976.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..782
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..782
                     /product="transducin-like enhancer protein 3 isoform X1"
                     /calculated_mol_wt=84347
     Region          18..143
                     /region_name="TLE_N"
                     /note="Groucho/TLE N-terminal Q-rich domain; pfam03920"
                     /db_xref="CDD:461094"
     Region          <495..780
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          499..538
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          546..584
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          589..625
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          632..667
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          672..705
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          713..747
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          754..778
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..782
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /coded_by="XM_011521976.4:1120..3468"
                     /db_xref="GeneID:7090"
                     /db_xref="HGNC:HGNC:11839"
                     /db_xref="MIM:600190"
ORIGIN      
        1 mypqgrhpap hqpgqpgfkf tvaescdrik defqflqaqy hslkveydkl anektemqrh
       61 yvmyyemsyg lniemhkqte iakrlntila qimpflsqeh qqqvaqaver akqvtmteln
      121 aiigvrglpn lpltqqqlqa qhlshathgp pvqlpphpsg lqppgippvt gsssgllalg
      181 algsqahltv kdeknhheld hreressann svspseslra sekhrgsady smeakkrkae
      241 ekdslsryds dgdksddlvv dvsnedpatp rvspahsppe ngldkarslk kdaptspasv
      301 asssstpssk tkdlghndks stpglksntp tprndaptpg tsttpglrsm pgkppgmdpi
      361 gimasalrtp isitssyaap fammshhemn gsltspgaya glhnippqms aaaaaaaaay
      421 grspmvsfga vgfdphppmr atglpsslas ipggkpaysf hvsadgqmqp vpfphdalag
      481 pgiprharqi ntlshgevvc avtisnptrh vytggkgcvk iwdisqpgsk spisqldcln
      541 rdnyirsckl lpdgrtlivg geastltiwd lasptprika eltssapacy alaispdakv
      601 cfsccsdgni avwdlhnqtl vrqfqghtdg ascidishdg tklwtggldn tvrswdlreg
      661 rqlqqhdfts qifslgycpt gewlavgmes snvevlhhtk pdkyqlhlhe scvlslkfay
      721 cgkwfvstgk dnllnawrtp ygasifqske sssvlscdis addkyivtgs gdkkatvyev
      781 iy
//
LOCUS       XP_011520279             781 aa            linear   PRI 05-AUG-2025
DEFINITION  transducin-like enhancer protein 3 isoform X2 [Homo sapiens].
ACCESSION   XP_011520279
VERSION     XP_011520279.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521977.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..781
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..781
                     /product="transducin-like enhancer protein 3 isoform X2"
                     /calculated_mol_wt=84219
     Region          18..142
                     /region_name="TLE_N"
                     /note="Groucho/TLE N-terminal Q-rich domain; pfam03920"
                     /db_xref="CDD:461094"
     Region          <494..779
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          498..537
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          545..583
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          588..624
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          631..666
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          671..704
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          712..746
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          753..777
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..781
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /coded_by="XM_011521977.4:1120..3465"
                     /db_xref="GeneID:7090"
                     /db_xref="HGNC:HGNC:11839"
                     /db_xref="MIM:600190"
ORIGIN      
        1 mypqgrhpap hqpgqpgfkf tvaescdrik defqflqaqy hslkveydkl anektemqrh
       61 yvmyyemsyg lniemhkqte iakrlntila qimpflsqeh qqqvaqaver akqvtmteln
      121 aiigvrglpn lpltqqlqaq hlshathgpp vqlpphpsgl qppgippvtg sssgllalga
      181 lgsqahltvk deknhheldh reressanns vspseslras ekhrgsadys meakkrkaee
      241 kdslsrydsd gdksddlvvd vsnedpatpr vspahsppen gldkarslkk daptspasva
      301 sssstpsskt kdlghndkss tpglksntpt prndaptpgt sttpglrsmp gkppgmdpig
      361 imasalrtpi sitssyaapf ammshhemng sltspgayag lhnippqmsa aaaaaaaayg
      421 rspmvsfgav gfdphppmra tglpsslasi pggkpaysfh vsadgqmqpv pfphdalagp
      481 giprharqin tlshgevvca vtisnptrhv ytggkgcvki wdisqpgsks pisqldclnr
      541 dnyirsckll pdgrtlivgg eastltiwdl asptprikae ltssapacya laispdakvc
      601 fsccsdgnia vwdlhnqtlv rqfqghtdga scidishdgt klwtggldnt vrswdlregr
      661 qlqqhdftsq ifslgycptg ewlavgmess nvevlhhtkp dkyqlhlhes cvlslkfayc
      721 gkwfvstgkd nllnawrtpy gasifqskes ssvlscdisa ddkyivtgsg dkkatvyevi
      781 y
//
LOCUS       XP_011520280             777 aa            linear   PRI 05-AUG-2025
DEFINITION  transducin-like enhancer protein 3 isoform X4 [Homo sapiens].
ACCESSION   XP_011520280
VERSION     XP_011520280.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521978.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..777
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..777
                     /product="transducin-like enhancer protein 3 isoform X4"
                     /calculated_mol_wt=83886
     Region          18..143
                     /region_name="TLE_N"
                     /note="Groucho/TLE N-terminal Q-rich domain; pfam03920"
                     /db_xref="CDD:461094"
     Region          <490..775
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          494..533
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          541..579
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          584..620
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          627..662
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          667..700
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          708..742
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          749..773
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..777
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /coded_by="XM_011521978.4:1120..3453"
                     /db_xref="GeneID:7090"
                     /db_xref="HGNC:HGNC:11839"
                     /db_xref="MIM:600190"
ORIGIN      
        1 mypqgrhpap hqpgqpgfkf tvaescdrik defqflqaqy hslkveydkl anektemqrh
       61 yvmyyemsyg lniemhkqte iakrlntila qimpflsqeh qqqvaqaver akqvtmteln
      121 aiigvrglpn lpltqqqlqa qhlshathgp pvqlpphpsg lqppgippvt gsssgllalg
      181 algsqahltv kdeknhheld hreressann svspseslra sekhrgsady smeakkrkae
      241 ekdslsryds dgdksddlvv dvsnedpatp rvspahsppe ngldkarslk kdaptspasv
      301 asssstpssk tkdlghndks stpglksntp tprndaptpg tsttpglrsm pgkppgmdpi
      361 gimasalrtp isitssyaap fammshhemn gsltspgaya glhnippqms aaaaaaaaay
      421 grspmvgfdp hppmratglp sslasipggk paysfhvsad gqmqpvpfph dalagpgipr
      481 harqintlsh gevvcavtis nptrhvytgg kgcvkiwdis qpgskspisq ldclnrdnyi
      541 rsckllpdgr tlivggeast ltiwdlaspt prikaeltss apacyalais pdakvcfscc
      601 sdgniavwdl hnqtlvrqfq ghtdgascid ishdgtklwt ggldntvrsw dlregrqlqq
      661 hdftsqifsl gycptgewla vgmessnvev lhhtkpdkyq lhlhescvls lkfaycgkwf
      721 vstgkdnlln awrtpygasi fqskesssvl scdisaddky ivtgsgdkka tvyeviy
//
LOCUS       XP_011520282             771 aa            linear   PRI 05-AUG-2025
DEFINITION  transducin-like enhancer protein 3 isoform X7 [Homo sapiens].
ACCESSION   XP_011520282
VERSION     XP_011520282.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521980.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..771
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..771
                     /product="transducin-like enhancer protein 3 isoform X7"
                     /calculated_mol_wt=83158
     Region          18..132
                     /region_name="TLE_N"
                     /note="Groucho/TLE N-terminal Q-rich domain; pfam03920"
                     /db_xref="CDD:461094"
     Region          <484..769
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          488..527
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          535..573
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          578..614
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          621..656
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          661..694
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          702..736
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          743..767
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..771
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /coded_by="XM_011521980.4:1120..3435"
                     /db_xref="GeneID:7090"
                     /db_xref="HGNC:HGNC:11839"
                     /db_xref="MIM:600190"
ORIGIN      
        1 mypqgrhpap hqpgqpgfkf tvaescdrik defqflqaqy hslkveydkl anektemqrh
       61 yvmyyemsyg lniemhkqte iakrlntila qimpflsqeh qqqvaqaver akqvtmteln
      121 aiigqqlqaq hlshathgpp vqlpphpsgl qppgippvtg sssgllalga lgsqahltvk
      181 deknhheldh reressanns vspseslras ekhrgsadys meakkrkaee kdslsrydsd
      241 gdksddlvvd vsnedpatpr vspahsppen gldkarslkk daptspasva sssstpsskt
      301 kdlghndkss tpglksntpt prndaptpgt sttpglrsmp gkppgmdpig imasalrtpi
      361 sitssyaapf ammshhemng sltspgayag lhnippqmsa aaaaaaaayg rspmvsfgav
      421 gfdphppmra tglpsslasi pggkpaysfh vsadgqmqpv pfphdalagp giprharqin
      481 tlshgevvca vtisnptrhv ytggkgcvki wdisqpgsks pisqldclnr dnyirsckll
      541 pdgrtlivgg eastltiwdl asptprikae ltssapacya laispdakvc fsccsdgnia
      601 vwdlhnqtlv rqfqghtdga scidishdgt klwtggldnt vrswdlregr qlqqhdftsq
      661 ifslgycptg ewlavgmess nvevlhhtkp dkyqlhlhes cvlslkfayc gkwfvstgkd
      721 nllnawrtpy gasifqskes ssvlscdisa ddkyivtgsg dkkatvyevi y
//
LOCUS       XP_005254682             770 aa            linear   PRI 05-AUG-2025
DEFINITION  transducin-like enhancer protein 3 isoform X8 [Homo sapiens].
ACCESSION   XP_005254682
VERSION     XP_005254682.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254625.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..770
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..770
                     /product="transducin-like enhancer protein 3 isoform X8"
                     /calculated_mol_wt=83153
     Region          18..143
                     /region_name="TLE_N"
                     /note="Groucho/TLE N-terminal Q-rich domain; pfam03920"
                     /db_xref="CDD:461094"
     Region          <261..470
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          <483..768
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          487..526
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          534..572
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          577..613
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          620..655
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          660..693
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          701..735
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          742..766
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..770
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /coded_by="XM_005254625.5:1120..3432"
                     /db_xref="GeneID:7090"
                     /db_xref="HGNC:HGNC:11839"
                     /db_xref="MIM:600190"
ORIGIN      
        1 mypqgrhpap hqpgqpgfkf tvaescdrik defqflqaqy hslkveydkl anektemqrh
       61 yvmyyemsyg lniemhkqte iakrlntila qimpflsqeh qqqvaqaver akqvtmteln
      121 aiigvrglpn lpltqqqlqa qhlshathgp pvqlpphpsg lqppgippvt gsssgllalg
      181 algsqahltv kdeknhheld hreressann svspseslra sekhrgsady smeakkrkae
      241 ekdslsryds dgdksddlvv dvsnedpatp rvspahsppe ngldkarslk kdaptspasv
      301 asssstpssk tkdlghndks stpglksntp tprndaptpg tsttpglrsm pasalrtpis
      361 itssyaapfa mmshhemngs ltspgayagl hnippqmsaa aaaaaaaygr spmvsfgavg
      421 fdphppmrat glpsslasip ggkpaysfhv sadgqmqpvp fphdalagpg iprharqint
      481 lshgevvcav tisnptrhvy tggkgcvkiw disqpgsksp isqldclnrd nyirsckllp
      541 dgrtlivgge astltiwdla sptprikael tssapacyal aispdakvcf sccsdgniav
      601 wdlhnqtlvr qfqghtdgas cidishdgtk lwtggldntv rswdlregrq lqqhdftsqi
      661 fslgycptge wlavgmessn vevlhhtkpd kyqlhlhesc vlslkfaycg kwfvstgkdn
      721 llnawrtpyg asifqskess svlscdisad dkyivtgsgd kkatvyeviy
//
LOCUS       XP_011520283             767 aa            linear   PRI 05-AUG-2025
DEFINITION  transducin-like enhancer protein 3 isoform X9 [Homo sapiens].
ACCESSION   XP_011520283
VERSION     XP_011520283.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521981.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..767
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..767
                     /product="transducin-like enhancer protein 3 isoform X9"
                     /calculated_mol_wt=82813
     Region          18..143
                     /region_name="TLE_N"
                     /note="Groucho/TLE N-terminal Q-rich domain; pfam03920"
                     /db_xref="CDD:461094"
     Region          <488..740
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          499..538
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          546..584
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          589..625
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          632..667
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          672..705
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          713..739
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..767
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /coded_by="XM_011521981.3:1120..3423"
                     /db_xref="GeneID:7090"
                     /db_xref="HGNC:HGNC:11839"
                     /db_xref="MIM:600190"
ORIGIN      
        1 mypqgrhpap hqpgqpgfkf tvaescdrik defqflqaqy hslkveydkl anektemqrh
       61 yvmyyemsyg lniemhkqte iakrlntila qimpflsqeh qqqvaqaver akqvtmteln
      121 aiigvrglpn lpltqqqlqa qhlshathgp pvqlpphpsg lqppgippvt gsssgllalg
      181 algsqahltv kdeknhheld hreressann svspseslra sekhrgsady smeakkrkae
      241 ekdslsryds dgdksddlvv dvsnedpatp rvspahsppe ngldkarslk kdaptspasv
      301 asssstpssk tkdlghndks stpglksntp tprndaptpg tsttpglrsm pgkppgmdpi
      361 gimasalrtp isitssyaap fammshhemn gsltspgaya glhnippqms aaaaaaaaay
      421 grspmvsfga vgfdphppmr atglpsslas ipggkpaysf hvsadgqmqp vpfphdalag
      481 pgiprharqi ntlshgevvc avtisnptrh vytggkgcvk iwdisqpgsk spisqldcln
      541 rdnyirsckl lpdgrtlivg geastltiwd lasptprika eltssapacy alaispdakv
      601 cfsccsdgni avwdlhnqtl vrqfqghtdg ascidishdg tklwtggldn tvrswdlreg
      661 rqlqqhdfts qifslgycpt gewlavgmes snvevlhhtk pdkyqlhlhe scvlslkfay
      721 cgkwfvstgk dnllnawrtp ygasifqvga sergrggqll preprwc
//
LOCUS       XP_005254685             765 aa            linear   PRI 05-AUG-2025
DEFINITION  transducin-like enhancer protein 3 isoform X10 [Homo sapiens].
ACCESSION   XP_005254685
VERSION     XP_005254685.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254628.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..765
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..765
                     /product="transducin-like enhancer protein 3 isoform X10"
                     /calculated_mol_wt=82691
     Region          18..143
                     /region_name="TLE_N"
                     /note="Groucho/TLE N-terminal Q-rich domain; pfam03920"
                     /db_xref="CDD:461094"
     Region          <478..763
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          482..521
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          529..567
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          572..608
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          615..650
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          655..688
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          696..730
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          737..761
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..765
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /coded_by="XM_005254628.5:1120..3417"
                     /db_xref="GeneID:7090"
                     /db_xref="HGNC:HGNC:11839"
                     /db_xref="MIM:600190"
ORIGIN      
        1 mypqgrhpap hqpgqpgfkf tvaescdrik defqflqaqy hslkveydkl anektemqrh
       61 yvmyyemsyg lniemhkqte iakrlntila qimpflsqeh qqqvaqaver akqvtmteln
      121 aiigvrglpn lpltqqqlqa qhlshathgp pvqlpphpsg lqppgippvt gsssgllalg
      181 algsqahltv kdeknhheld hreressann svspseslra sekhrgsady smeakkrkae
      241 ekdslsryds dgdksddlvv dvsnedpatp rvspahsppe ngldkarslk kdaptspasv
      301 asssstpssk tkdlghndks stpglksntp tprndaptpg tsttpglrsm pasalrtpis
      361 itssyaapfa mmshhemngs ltspgayagl hnippqmsaa aaaaaaaygr spmvgfdphp
      421 pmratglpss lasipggkpa ysfhvsadgq mqpvpfphda lagpgiprha rqintlshge
      481 vvcavtisnp trhvytggkg cvkiwdisqp gskspisqld clnrdnyirs ckllpdgrtl
      541 ivggeastlt iwdlasptpr ikaeltssap acyalaispd akvcfsccsd gniavwdlhn
      601 qtlvrqfqgh tdgascidis hdgtklwtgg ldntvrswdl regrqlqqhd ftsqifslgy
      661 cptgewlavg messnvevlh htkpdkyqlh lhescvlslk faycgkwfvs tgkdnllnaw
      721 rtpygasifq skesssvlsc disaddkyiv tgsgdkkatv yeviy
//
LOCUS       XP_011520284             698 aa            linear   PRI 05-AUG-2025
DEFINITION  transducin-like enhancer protein 3 isoform X11 [Homo sapiens].
ACCESSION   XP_011520284
VERSION     XP_011520284.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521982.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..698
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..698
                     /product="transducin-like enhancer protein 3 isoform X11"
                     /calculated_mol_wt=75492
     Region          18..124
                     /region_name="TLE_N"
                     /note="Groucho/TLE N-terminal Q-rich domain; pfam03920"
                     /db_xref="CDD:461094"
     Region          <411..696
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          415..454
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          462..500
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          505..541
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          548..583
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          588..621
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          629..663
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          670..694
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..698
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /coded_by="XM_011521982.4:1120..3216"
                     /db_xref="GeneID:7090"
                     /db_xref="HGNC:HGNC:11839"
                     /db_xref="MIM:600190"
ORIGIN      
        1 mypqgrhpap hqpgqpgfkf tvaescdrik defqflqaqy hslkveydkl anektemqrh
       61 yvmyyemsyg lniemhkqte iakrlntila qimpflsqeh qqqvaqaver akqvtmteln
      121 aiignnsvsp seslrasekh rgsadysmea kkrkaeekds lsrydsdgdk sddlvvdvsn
      181 edpatprvsp ahsppengld karslkkdap tspasvasss stpssktkdl ghndksstpg
      241 lksntptprn daptpgtstt pglrsmpgkp pgmdpigima salrtpisit ssyaapfamm
      301 shhemngslt spgayaglhn ippqmsaaaa aaaaaygrsp mvsfgavgfd phppmratgl
      361 psslasipgg kpaysfhvsa dgqmqpvpfp hdalagpgip rharqintls hgevvcavti
      421 snptrhvytg gkgcvkiwdi sqpgskspis qldclnrdny irsckllpdg rtlivggeas
      481 tltiwdlasp tprikaelts sapacyalai spdakvcfsc csdgniavwd lhnqtlvrqf
      541 qghtdgasci dishdgtklw tggldntvrs wdlregrqlq qhdftsqifs lgycptgewl
      601 avgmessnve vlhhtkpdky qlhlhescvl slkfaycgkw fvstgkdnll nawrtpygas
      661 ifqskesssv lscdisaddk yivtgsgdkk atvyeviy
//
LOCUS       XP_047288948             695 aa            linear   PRI 05-AUG-2025
DEFINITION  transducin-like enhancer protein 3 isoform X12 [Homo sapiens].
ACCESSION   XP_047288948
VERSION     XP_047288948.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432992.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..695
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..695
                     /product="transducin-like enhancer protein 3 isoform X12"
                     /calculated_mol_wt=75191
     Region          18..124
                     /region_name="TLE_N"
                     /note="Groucho/TLE N-terminal Q-rich domain; pfam03920"
                     /db_xref="CDD:461094"
     Region          <408..693
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          412..451
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          459..497
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          502..538
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          545..580
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          585..618
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          626..660
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          667..691
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..695
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /coded_by="XM_047432992.1:1120..3207"
                     /db_xref="GeneID:7090"
                     /db_xref="HGNC:HGNC:11839"
                     /db_xref="MIM:600190"
ORIGIN      
        1 mypqgrhpap hqpgqpgfkf tvaescdrik defqflqaqy hslkveydkl anektemqrh
       61 yvmyyemsyg lniemhkqte iakrlntila qimpflsqeh qqqvaqaver akqvtmteln
      121 aiignnsvsp seslrasekh rgsadysmea kkrkaeekds lsrydsdgdk sddlvvdvsn
      181 edpatprvsp ahsppengld karslkkdap tspasvasss stpssktkdl ghndksstpg
      241 lksntptprn daptpgtstt pglrsmpgkp pgmdpiasal rtpisitssy aapfammshh
      301 emngsltspg ayaglhnipp qmsaaaaaaa aaygrspmvs fgavgfdphp pmratglpss
      361 lasipggkpa ysfhvsadgq mqpvpfphda lagpgiprha rqintlshge vvcavtisnp
      421 trhvytggkg cvkiwdisqp gskspisqld clnrdnyirs ckllpdgrtl ivggeastlt
      481 iwdlasptpr ikaeltssap acyalaispd akvcfsccsd gniavwdlhn qtlvrqfqgh
      541 tdgascidis hdgtklwtgg ldntvrswdl regrqlqqhd ftsqifslgy cptgewlavg
      601 messnvevlh htkpdkyqlh lhescvlslk faycgkwfvs tgkdnllnaw rtpygasifq
      661 skesssvlsc disaddkyiv tgsgdkkatv yeviy
//
LOCUS       XP_011520285             693 aa            linear   PRI 05-AUG-2025
DEFINITION  transducin-like enhancer protein 3 isoform X13 [Homo sapiens].
ACCESSION   XP_011520285
VERSION     XP_011520285.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521983.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..693
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..693
                     /product="transducin-like enhancer protein 3 isoform X13"
                     /calculated_mol_wt=75031
     Region          18..124
                     /region_name="TLE_N"
                     /note="Groucho/TLE N-terminal Q-rich domain; pfam03920"
                     /db_xref="CDD:461094"
     Region          <406..691
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          410..449
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          457..495
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          500..536
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          543..578
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          583..616
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          624..658
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          665..689
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..693
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /coded_by="XM_011521983.4:1120..3201"
                     /db_xref="GeneID:7090"
                     /db_xref="HGNC:HGNC:11839"
                     /db_xref="MIM:600190"
ORIGIN      
        1 mypqgrhpap hqpgqpgfkf tvaescdrik defqflqaqy hslkveydkl anektemqrh
       61 yvmyyemsyg lniemhkqte iakrlntila qimpflsqeh qqqvaqaver akqvtmteln
      121 aiignnsvsp seslrasekh rgsadysmea kkrkaeekds lsrydsdgdk sddlvvdvsn
      181 edpatprvsp ahsppengld karslkkdap tspasvasss stpssktkdl ghndksstpg
      241 lksntptprn daptpgtstt pglrsmpgkp pgmdpigima salrtpisit ssyaapfamm
      301 shhemngslt spgayaglhn ippqmsaaaa aaaaaygrsp mvgfdphppm ratglpssla
      361 sipggkpays fhvsadgqmq pvpfphdala gpgiprharq intlshgevv cavtisnptr
      421 hvytggkgcv kiwdisqpgs kspisqldcl nrdnyirsck llpdgrtliv ggeastltiw
      481 dlasptprik aeltssapac yalaispdak vcfsccsdgn iavwdlhnqt lvrqfqghtd
      541 gascidishd gtklwtggld ntvrswdlre grqlqqhdft sqifslgycp tgewlavgme
      601 ssnvevlhht kpdkyqlhlh escvlslkfa ycgkwfvstg kdnllnawrt pygasifqsk
      661 esssvlscdi saddkyivtg sgdkkatvye viy
//
LOCUS       XP_047288949             690 aa            linear   PRI 05-AUG-2025
DEFINITION  transducin-like enhancer protein 3 isoform X14 [Homo sapiens].
ACCESSION   XP_047288949
VERSION     XP_047288949.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432993.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..690
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..690
                     /product="transducin-like enhancer protein 3 isoform X14"
                     /calculated_mol_wt=74729
     Region          18..124
                     /region_name="TLE_N"
                     /note="Groucho/TLE N-terminal Q-rich domain; pfam03920"
                     /db_xref="CDD:461094"
     Region          <403..688
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          407..446
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          454..492
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          497..533
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          540..575
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          580..613
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          621..655
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          662..686
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..690
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /coded_by="XM_047432993.1:1120..3192"
                     /db_xref="GeneID:7090"
                     /db_xref="HGNC:HGNC:11839"
                     /db_xref="MIM:600190"
ORIGIN      
        1 mypqgrhpap hqpgqpgfkf tvaescdrik defqflqaqy hslkveydkl anektemqrh
       61 yvmyyemsyg lniemhkqte iakrlntila qimpflsqeh qqqvaqaver akqvtmteln
      121 aiignnsvsp seslrasekh rgsadysmea kkrkaeekds lsrydsdgdk sddlvvdvsn
      181 edpatprvsp ahsppengld karslkkdap tspasvasss stpssktkdl ghndksstpg
      241 lksntptprn daptpgtstt pglrsmpgkp pgmdpiasal rtpisitssy aapfammshh
      301 emngsltspg ayaglhnipp qmsaaaaaaa aaygrspmvg fdphppmrat glpsslasip
      361 ggkpaysfhv sadgqmqpvp fphdalagpg iprharqint lshgevvcav tisnptrhvy
      421 tggkgcvkiw disqpgsksp isqldclnrd nyirsckllp dgrtlivgge astltiwdla
      481 sptprikael tssapacyal aispdakvcf sccsdgniav wdlhnqtlvr qfqghtdgas
      541 cidishdgtk lwtggldntv rswdlregrq lqqhdftsqi fslgycptge wlavgmessn
      601 vevlhhtkpd kyqlhlhesc vlslkfaycg kwfvstgkdn llnawrtpyg asifqskess
      661 svlscdisad dkyivtgsgd kkatvyeviy
//
LOCUS       XP_016878021             555 aa            linear   PRI 05-AUG-2025
DEFINITION  transducin-like enhancer protein 3 isoform X15 [Homo sapiens].
ACCESSION   XP_016878021
VERSION     XP_016878021.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022532.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..555
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..555
                     /product="transducin-like enhancer protein 3 isoform X15"
                     /calculated_mol_wt=59368
     Region          18..143
                     /region_name="TLE_N"
                     /note="Groucho/TLE N-terminal Q-rich domain; pfam03920"
                     /db_xref="CDD:461094"
     Region          499..538
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..555
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /coded_by="XM_017022532.3:1120..2787"
                     /db_xref="GeneID:7090"
                     /db_xref="HGNC:HGNC:11839"
                     /db_xref="MIM:600190"
ORIGIN      
        1 mypqgrhpap hqpgqpgfkf tvaescdrik defqflqaqy hslkveydkl anektemqrh
       61 yvmyyemsyg lniemhkqte iakrlntila qimpflsqeh qqqvaqaver akqvtmteln
      121 aiigvrglpn lpltqqqlqa qhlshathgp pvqlpphpsg lqppgippvt gsssgllalg
      181 algsqahltv kdeknhheld hreressann svspseslra sekhrgsady smeakkrkae
      241 ekdslsryds dgdksddlvv dvsnedpatp rvspahsppe ngldkarslk kdaptspasv
      301 asssstpssk tkdlghndks stpglksntp tprndaptpg tsttpglrsm pgkppgmdpi
      361 gimasalrtp isitssyaap fammshhemn gsltspgaya glhnippqms aaaaaaaaay
      421 grspmvsfga vgfdphppmr atglpsslas ipggkpaysf hvsadgqmqp vpfphdalag
      481 pgiprharqi ntlshgevvc avtisnptrh vytggkgcvk iwdisqpgsk spisqldcla
      541 vpgphrwgql hrhlp
//
LOCUS       XP_047288950            1977 aa            linear   PRI 05-AUG-2025
DEFINITION  TP53-binding protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047288950
VERSION     XP_047288950.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432994.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1977
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1977
                     /product="TP53-binding protein 1 isoform X1"
                     /calculated_mol_wt=213987
     Region          1490..1607
                     /region_name="53-BP1_Tudor"
                     /note="Tumour suppressor p53-binding protein-1 Tudor;
                     pfam09038"
                     /db_xref="CDD:430382"
     Site            order(1500,1507,1524,1526..1528)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:410454"
     Site            order(1500,1507,1524,1526,1528)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:410454"
     Region          1733..1844
                     /region_name="BRCT_p53bp1_rpt1"
                     /note="first (central) BRCT domain in p53-binding protein
                     1 (p53BP1) and similar proteins; cd17745"
                     /db_xref="CDD:349376"
     Site            order(1742..1743,1815..1819)
                     /site_type="other"
                     /note="gamma-H2A interaction site [polypeptide binding]"
                     /db_xref="CDD:349376"
     Site            order(1832,1834,1838,1841)
                     /site_type="other"
                     /note="p53 interaction site [polypeptide binding]"
                     /db_xref="CDD:349376"
     Region          1872..1975
                     /region_name="BRCT_3"
                     /note="BRCA1 C Terminus (BRCT) domain; pfam18428"
                     /db_xref="CDD:465764"
     CDS             1..1977
                     /gene="TP53BP1"
                     /gene_synonym="53BP1; p202; p53BP1; TDRD30"
                     /coded_by="XM_047432994.1:486..6419"
                     /db_xref="GeneID:7158"
                     /db_xref="HGNC:HGNC:11999"
                     /db_xref="MIM:605230"
ORIGIN      
        1 mpgeqmdptg sqldsdfsqq dtpcliieds qpesqvledd sgshfsmlsr hlpnlqthke
       61 npvldvvsnp eqtageergd gnsgfnehlk enkvadpvds snldtcgsis qvieqlpqpn
      121 rtssvlgmsv esapaveeek geeleqkeke keedtsgntt hslgaedtas sqlgfgvlel
      181 sqsqdveent vpyevdkeql qsvttnsgyt rlsdvdanta ikheeqsned ipiaeqsskd
      241 ipvtaqpskd vhvvkeqnpp parsedmpfs pkasvaamea keqlsaqelm esglqiqksp
      301 epevlstqed lfdqsnktvs sdgcstpsre eggcslastp attlhllqls gqrslvqdsl
      361 stnssdlvap spdafrstpf ivpsspteqe grqdkpmdts vlseeggepf qkklqsgepv
      421 elenppllpe stvspqastp isqstpvfpp gslpipsqpq fshdifipsp sleeqsndgk
      481 kdgdmhsssl tvecsktsei epknspedlg lsltgdsckl mlstseysqs pkmeslsshr
      541 idedgentqi edtepmspvl nskfvpaend silmnpaqdg evqlsqnddk tkgddtdtrd
      601 disilatgck greetvaedv cidltcdsgs qavpspatrs ealssvldqe eameikehhp
      661 eegssgseve eipetpcesq geelkeenme svplhlslte tqsqglclqk empkkecsea
      721 mevetsvisi dspqklaild qelehkeqea weeatsedss vvivdvkeps prvdvscepl
      781 egvekcsdsq swediapeie pcaenrldtk eeksveyegd lksgtaetep veqdssqpsl
      841 plvraddplr ldqelqqpqt qektsnslte dskmanakql ssdaeaqklg kpsahasqsf
      901 cesssetpfh ftlpkegdii ppltgatppl ighlklepkr hstpigisny pestiatsdv
      961 msesmvethd pilgsgkgds gaapdvddkl clrmklvspe teaseeslqf nlekpatger
     1021 kngstavaes vaspqktmsv lscicearqe nearsedppt tpirgnllhf pssqgeeeke
     1081 klegdhtirq sqqpmkpisp vkdpvspasq kmviqgpssp qgeamvtdvl edqkegrstn
     1141 kenpskalie rpsqnnigiq tmecslrvpe tvsaatqtik nvceqgtstv dqnfgkqdat
     1201 vqtergsgek pvsapgddte slhsqgeeef dmpqpphghv lhrhmrtire vrtlvtrvit
     1261 dvyyvdgtev erkvteetee pivecqecet evspsqtggs sgdlgdissf sskasslhrt
     1321 ssgtslsamh ssgssgkgag plrgktsgte padfalpssr ggpgklsprk gvsqtgtpvc
     1381 eedgdaglgi rqggkapvtp rgrgrrgrpp srttgtreta vpgplgiedi spnlspddks
     1441 fsrvvprvpd strrtdvgag alrrsdspei pfqaaagpsd gldasspgns fvglrvvakw
     1501 ssngyfysgk itrdvgagky kllfddgyec dvlgkdillc dpipldtevt alsedeyfsa
     1561 gvvkghrkes gelyysieke gqrkwykrma vilsleqgnr lreqyglgpy eavtpltkaa
     1621 disldnlveg krkrrsnvss patptassss sttptrkite sprasmgvls gkrklitsee
     1681 erspakrgrk satvkpgavg agefvspces gdntgepsal eeqrgplpln ktlflgyafl
     1741 ltmattsdkl asrsklpdgp tgsseeeeef leippfnkqy tesqlragag yiledfneaq
     1801 cntayqclli adqhcrtrky flclasgipc vshvwvhdsc hanqlqnyrn yllpagysle
     1861 eqrildwqpr enpfqnlkvl lvsdqqqnfl elwseilmtg gaasvkqhhs sahnkdialg
     1921 vfdvvvtdps cpasvlkcae alqlpvvsqe wviqclivge rigfkqhpky khdyvsh
//
LOCUS       XP_047288951            1977 aa            linear   PRI 05-AUG-2025
DEFINITION  TP53-binding protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047288951
VERSION     XP_047288951.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432995.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1977
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1977
                     /product="TP53-binding protein 1 isoform X1"
                     /calculated_mol_wt=213987
     Region          1490..1607
                     /region_name="53-BP1_Tudor"
                     /note="Tumour suppressor p53-binding protein-1 Tudor;
                     pfam09038"
                     /db_xref="CDD:430382"
     Site            order(1500,1507,1524,1526..1528)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:410454"
     Site            order(1500,1507,1524,1526,1528)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:410454"
     Region          1733..1844
                     /region_name="BRCT_p53bp1_rpt1"
                     /note="first (central) BRCT domain in p53-binding protein
                     1 (p53BP1) and similar proteins; cd17745"
                     /db_xref="CDD:349376"
     Site            order(1742..1743,1815..1819)
                     /site_type="other"
                     /note="gamma-H2A interaction site [polypeptide binding]"
                     /db_xref="CDD:349376"
     Site            order(1832,1834,1838,1841)
                     /site_type="other"
                     /note="p53 interaction site [polypeptide binding]"
                     /db_xref="CDD:349376"
     Region          1872..1975
                     /region_name="BRCT_3"
                     /note="BRCA1 C Terminus (BRCT) domain; pfam18428"
                     /db_xref="CDD:465764"
     CDS             1..1977
                     /gene="TP53BP1"
                     /gene_synonym="53BP1; p202; p53BP1; TDRD30"
                     /coded_by="XM_047432995.1:625..6558"
                     /db_xref="GeneID:7158"
                     /db_xref="HGNC:HGNC:11999"
                     /db_xref="MIM:605230"
ORIGIN      
        1 mpgeqmdptg sqldsdfsqq dtpcliieds qpesqvledd sgshfsmlsr hlpnlqthke
       61 npvldvvsnp eqtageergd gnsgfnehlk enkvadpvds snldtcgsis qvieqlpqpn
      121 rtssvlgmsv esapaveeek geeleqkeke keedtsgntt hslgaedtas sqlgfgvlel
      181 sqsqdveent vpyevdkeql qsvttnsgyt rlsdvdanta ikheeqsned ipiaeqsskd
      241 ipvtaqpskd vhvvkeqnpp parsedmpfs pkasvaamea keqlsaqelm esglqiqksp
      301 epevlstqed lfdqsnktvs sdgcstpsre eggcslastp attlhllqls gqrslvqdsl
      361 stnssdlvap spdafrstpf ivpsspteqe grqdkpmdts vlseeggepf qkklqsgepv
      421 elenppllpe stvspqastp isqstpvfpp gslpipsqpq fshdifipsp sleeqsndgk
      481 kdgdmhsssl tvecsktsei epknspedlg lsltgdsckl mlstseysqs pkmeslsshr
      541 idedgentqi edtepmspvl nskfvpaend silmnpaqdg evqlsqnddk tkgddtdtrd
      601 disilatgck greetvaedv cidltcdsgs qavpspatrs ealssvldqe eameikehhp
      661 eegssgseve eipetpcesq geelkeenme svplhlslte tqsqglclqk empkkecsea
      721 mevetsvisi dspqklaild qelehkeqea weeatsedss vvivdvkeps prvdvscepl
      781 egvekcsdsq swediapeie pcaenrldtk eeksveyegd lksgtaetep veqdssqpsl
      841 plvraddplr ldqelqqpqt qektsnslte dskmanakql ssdaeaqklg kpsahasqsf
      901 cesssetpfh ftlpkegdii ppltgatppl ighlklepkr hstpigisny pestiatsdv
      961 msesmvethd pilgsgkgds gaapdvddkl clrmklvspe teaseeslqf nlekpatger
     1021 kngstavaes vaspqktmsv lscicearqe nearsedppt tpirgnllhf pssqgeeeke
     1081 klegdhtirq sqqpmkpisp vkdpvspasq kmviqgpssp qgeamvtdvl edqkegrstn
     1141 kenpskalie rpsqnnigiq tmecslrvpe tvsaatqtik nvceqgtstv dqnfgkqdat
     1201 vqtergsgek pvsapgddte slhsqgeeef dmpqpphghv lhrhmrtire vrtlvtrvit
     1261 dvyyvdgtev erkvteetee pivecqecet evspsqtggs sgdlgdissf sskasslhrt
     1321 ssgtslsamh ssgssgkgag plrgktsgte padfalpssr ggpgklsprk gvsqtgtpvc
     1381 eedgdaglgi rqggkapvtp rgrgrrgrpp srttgtreta vpgplgiedi spnlspddks
     1441 fsrvvprvpd strrtdvgag alrrsdspei pfqaaagpsd gldasspgns fvglrvvakw
     1501 ssngyfysgk itrdvgagky kllfddgyec dvlgkdillc dpipldtevt alsedeyfsa
     1561 gvvkghrkes gelyysieke gqrkwykrma vilsleqgnr lreqyglgpy eavtpltkaa
     1621 disldnlveg krkrrsnvss patptassss sttptrkite sprasmgvls gkrklitsee
     1681 erspakrgrk satvkpgavg agefvspces gdntgepsal eeqrgplpln ktlflgyafl
     1741 ltmattsdkl asrsklpdgp tgsseeeeef leippfnkqy tesqlragag yiledfneaq
     1801 cntayqclli adqhcrtrky flclasgipc vshvwvhdsc hanqlqnyrn yllpagysle
     1861 eqrildwqpr enpfqnlkvl lvsdqqqnfl elwseilmtg gaasvkqhhs sahnkdialg
     1921 vfdvvvtdps cpasvlkcae alqlpvvsqe wviqclivge rigfkqhpky khdyvsh
//
LOCUS       XP_047288953            1917 aa            linear   PRI 05-AUG-2025
DEFINITION  TP53-binding protein 1 isoform X2 [Homo sapiens].
ACCESSION   XP_047288953
VERSION     XP_047288953.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432997.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1917
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1917
                     /product="TP53-binding protein 1 isoform X2"
                     /calculated_mol_wt=207285
     Region          1490..1607
                     /region_name="53-BP1_Tudor"
                     /note="Tumour suppressor p53-binding protein-1 Tudor;
                     pfam09038"
                     /db_xref="CDD:430382"
     Site            order(1500,1507,1524,1526..1528)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:410454"
     Site            order(1500,1507,1524,1526,1528)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:410454"
     Region          1733..1844
                     /region_name="BRCT_p53bp1_rpt1"
                     /note="first (central) BRCT domain in p53-binding protein
                     1 (p53BP1) and similar proteins; cd17745"
                     /db_xref="CDD:349376"
     Site            order(1742..1743,1815..1819)
                     /site_type="other"
                     /note="gamma-H2A interaction site [polypeptide binding]"
                     /db_xref="CDD:349376"
     Site            order(1832,1834,1838,1841)
                     /site_type="other"
                     /note="p53 interaction site [polypeptide binding]"
                     /db_xref="CDD:349376"
     Region          1872..>1914
                     /region_name="BRCT_3"
                     /note="BRCA1 C Terminus (BRCT) domain; pfam18428"
                     /db_xref="CDD:465764"
     CDS             1..1917
                     /gene="TP53BP1"
                     /gene_synonym="53BP1; p202; p53BP1; TDRD30"
                     /coded_by="XM_047432997.1:625..6378"
                     /db_xref="GeneID:7158"
                     /db_xref="HGNC:HGNC:11999"
                     /db_xref="MIM:605230"
ORIGIN      
        1 mpgeqmdptg sqldsdfsqq dtpcliieds qpesqvledd sgshfsmlsr hlpnlqthke
       61 npvldvvsnp eqtageergd gnsgfnehlk enkvadpvds snldtcgsis qvieqlpqpn
      121 rtssvlgmsv esapaveeek geeleqkeke keedtsgntt hslgaedtas sqlgfgvlel
      181 sqsqdveent vpyevdkeql qsvttnsgyt rlsdvdanta ikheeqsned ipiaeqsskd
      241 ipvtaqpskd vhvvkeqnpp parsedmpfs pkasvaamea keqlsaqelm esglqiqksp
      301 epevlstqed lfdqsnktvs sdgcstpsre eggcslastp attlhllqls gqrslvqdsl
      361 stnssdlvap spdafrstpf ivpsspteqe grqdkpmdts vlseeggepf qkklqsgepv
      421 elenppllpe stvspqastp isqstpvfpp gslpipsqpq fshdifipsp sleeqsndgk
      481 kdgdmhsssl tvecsktsei epknspedlg lsltgdsckl mlstseysqs pkmeslsshr
      541 idedgentqi edtepmspvl nskfvpaend silmnpaqdg evqlsqnddk tkgddtdtrd
      601 disilatgck greetvaedv cidltcdsgs qavpspatrs ealssvldqe eameikehhp
      661 eegssgseve eipetpcesq geelkeenme svplhlslte tqsqglclqk empkkecsea
      721 mevetsvisi dspqklaild qelehkeqea weeatsedss vvivdvkeps prvdvscepl
      781 egvekcsdsq swediapeie pcaenrldtk eeksveyegd lksgtaetep veqdssqpsl
      841 plvraddplr ldqelqqpqt qektsnslte dskmanakql ssdaeaqklg kpsahasqsf
      901 cesssetpfh ftlpkegdii ppltgatppl ighlklepkr hstpigisny pestiatsdv
      961 msesmvethd pilgsgkgds gaapdvddkl clrmklvspe teaseeslqf nlekpatger
     1021 kngstavaes vaspqktmsv lscicearqe nearsedppt tpirgnllhf pssqgeeeke
     1081 klegdhtirq sqqpmkpisp vkdpvspasq kmviqgpssp qgeamvtdvl edqkegrstn
     1141 kenpskalie rpsqnnigiq tmecslrvpe tvsaatqtik nvceqgtstv dqnfgkqdat
     1201 vqtergsgek pvsapgddte slhsqgeeef dmpqpphghv lhrhmrtire vrtlvtrvit
     1261 dvyyvdgtev erkvteetee pivecqecet evspsqtggs sgdlgdissf sskasslhrt
     1321 ssgtslsamh ssgssgkgag plrgktsgte padfalpssr ggpgklsprk gvsqtgtpvc
     1381 eedgdaglgi rqggkapvtp rgrgrrgrpp srttgtreta vpgplgiedi spnlspddks
     1441 fsrvvprvpd strrtdvgag alrrsdspei pfqaaagpsd gldasspgns fvglrvvakw
     1501 ssngyfysgk itrdvgagky kllfddgyec dvlgkdillc dpipldtevt alsedeyfsa
     1561 gvvkghrkes gelyysieke gqrkwykrma vilsleqgnr lreqyglgpy eavtpltkaa
     1621 disldnlveg krkrrsnvss patptassss sttptrkite sprasmgvls gkrklitsee
     1681 erspakrgrk satvkpgavg agefvspces gdntgepsal eeqrgplpln ktlflgyafl
     1741 ltmattsdkl asrsklpdgp tgsseeeeef leippfnkqy tesqlragag yiledfneaq
     1801 cntayqclli adqhcrtrky flclasgipc vshvwvhdsc hanqlqnyrn yllpagysle
     1861 eqrildwqpr enpfqnlkvl lvsdqqqnfl elwseilmtg gaasvkqhhs sahnkgt
//
LOCUS       XP_047288954            1867 aa            linear   PRI 05-AUG-2025
DEFINITION  TP53-binding protein 1 isoform X3 [Homo sapiens].
ACCESSION   XP_047288954
VERSION     XP_047288954.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432998.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1867
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1867
                     /product="TP53-binding protein 1 isoform X3"
                     /calculated_mol_wt=202187
     Region          1440..1557
                     /region_name="53-BP1_Tudor"
                     /note="Tumour suppressor p53-binding protein-1 Tudor;
                     pfam09038"
                     /db_xref="CDD:430382"
     Site            order(1450,1457,1474,1476..1478)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:410454"
     Site            order(1450,1457,1474,1476,1478)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:410454"
     Region          1683..1794
                     /region_name="BRCT_p53bp1_rpt1"
                     /note="first (central) BRCT domain in p53-binding protein
                     1 (p53BP1) and similar proteins; cd17745"
                     /db_xref="CDD:349376"
     Site            order(1692..1693,1765..1769)
                     /site_type="other"
                     /note="gamma-H2A interaction site [polypeptide binding]"
                     /db_xref="CDD:349376"
     Site            order(1782,1784,1788,1791)
                     /site_type="other"
                     /note="p53 interaction site [polypeptide binding]"
                     /db_xref="CDD:349376"
     Region          1822..>1864
                     /region_name="BRCT_3"
                     /note="BRCA1 C Terminus (BRCT) domain; pfam18428"
                     /db_xref="CDD:465764"
     CDS             1..1867
                     /gene="TP53BP1"
                     /gene_synonym="53BP1; p202; p53BP1; TDRD30"
                     /coded_by="XM_047432998.1:625..6228"
                     /db_xref="GeneID:7158"
                     /db_xref="HGNC:HGNC:11999"
                     /db_xref="MIM:605230"
ORIGIN      
        1 mpgeqmdptg sqldsdfsqq dtpcliieds qpesqvledd sgshfsmlsr hlpnlqthke
       61 npvldvvsnp eqtageergd gnsgfnehlk enkvadpvds snldtcgsis qvieqlpqpn
      121 rtssvlgmsv esapaveeek geeleqkeke keedtsgntt hslgaedtas sqlgfgvlel
      181 sqsqdveent vpyevdkeql qsvttnsgyt rlsdvdanta ikheeqsned ipiaeqsskd
      241 ipvtaqpskd vhvvkeqnpp parsedmpfs pkasvaamea keqlsaqelm esglqiqksp
      301 epevlstqed lfdqsnktvs sdgcstpsre eggcslastp attlhllqls gqrslvqdsl
      361 stnssdlvap spdafrstpf ivpsspteqe grqdkpmdts vlseeggepf qkklqsgepv
      421 elenppllpe stvspqastp isqstpvfpp gslpipsqpq fshdifipsp sleeqsndgk
      481 kdgdmhsssl tvecsktsei epknspedlg lsltgdsckl mlstseysqs pkmeslsshr
      541 idedgentqi edtepmspvl nskfvpaend silmnpaqdg evqlsqnddk tkgddtdtrd
      601 disilatgck greetvaedv cidltcdsgs qavpspatrs ealssvldqe eameikehhp
      661 eegssgseve eipetpcesq geelkeenme svplhlslte tqsqglclqk empkkecsea
      721 mevetsvisi dspqklaild qelehkeqea weeatsedss vvivdvkeps prvdvscepl
      781 egvekcsdsq swediapeie pcaenrldtk eeksveyegd lksgtaetep veqdssqpsl
      841 plvraddplr ldqelqqpqt qektsnslte dskmanakql ssdaeaqklg kpsahasqsf
      901 cesssetpfh ftlpkegdii ppltgatppl ighlklepkr hstpigisny pestiatsdv
      961 msesmvethd pilgsgkgds gaapdvddkl clrmklvspe teaseeslqf nlekpatger
     1021 kngstavaes vaspqktmsv lscicearqe nearsedppt tpirgnllhf pssqgeeeke
     1081 klegdhtirq sqqpmkpisp vkdpvspasq kmviqgpssp qgeamvtdvl edqkegrstn
     1141 kenpskalie rpsqnnigiq tmecslrvpe tvsaatqtik nvceqgtstv dqnfgkqdat
     1201 vqtergsgek pvsapgddte slhsqgeeef dmpqpphghv lhrhmrtire vrtlvtrvit
     1261 dvyyvdgtev erkvteetee pivecqecet evspsqtggs sgdlgdissf sskasslhrt
     1321 ssgtslsamh ssgssgkgag plrgktsgte padfalpssr ggpgklreta vpgplgiedi
     1381 spnlspddks fsrvvprvpd strrtdvgag alrrsdspei pfqaaagpsd gldasspgns
     1441 fvglrvvakw ssngyfysgk itrdvgagky kllfddgyec dvlgkdillc dpipldtevt
     1501 alsedeyfsa gvvkghrkes gelyysieke gqrkwykrma vilsleqgnr lreqyglgpy
     1561 eavtpltkaa disldnlveg krkrrsnvss patptassss sttptrkite sprasmgvls
     1621 gkrklitsee erspakrgrk satvkpgavg agefvspces gdntgepsal eeqrgplpln
     1681 ktlflgyafl ltmattsdkl asrsklpdgp tgsseeeeef leippfnkqy tesqlragag
     1741 yiledfneaq cntayqclli adqhcrtrky flclasgipc vshvwvhdsc hanqlqnyrn
     1801 yllpagysle eqrildwqpr enpfqnlkvl lvsdqqqnfl elwseilmtg gaasvkqhhs
     1861 sahnkgt
//
LOCUS       XP_047288955            1083 aa            linear   PRI 05-AUG-2025
DEFINITION  TP53-binding protein 1 isoform X4 [Homo sapiens].
ACCESSION   XP_047288955
VERSION     XP_047288955.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047432999.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1083
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1083
                     /product="TP53-binding protein 1 isoform X4"
                     /calculated_mol_wt=117110
     CDS             1..1083
                     /gene="TP53BP1"
                     /gene_synonym="53BP1; p202; p53BP1; TDRD30"
                     /coded_by="XM_047432999.1:625..3876"
                     /db_xref="GeneID:7158"
                     /db_xref="HGNC:HGNC:11999"
                     /db_xref="MIM:605230"
ORIGIN      
        1 mpgeqmdptg sqldsdfsqq dtpcliieds qpesqvledd sgshfsmlsr hlpnlqthke
       61 npvldvvsnp eqtageergd gnsgfnehlk enkvadpvds snldtcgsis qvieqlpqpn
      121 rtssvlgmsv esapaveeek geeleqkeke keedtsgntt hslgaedtas sqlgfgvlel
      181 sqsqdveent vpyevdkeql qsvttnsgyt rlsdvdanta ikheeqsned ipiaeqsskd
      241 ipvtaqpskd vhvvkeqnpp parsedmpfs pkasvaamea keqlsaqelm esglqiqksp
      301 epevlstqed lfdqsnktvs sdgcstpsre eggcslastp attlhllqls gqrslvqdsl
      361 stnssdlvap spdafrstpf ivpsspteqe grqdkpmdts vlseeggepf qkklqsgepv
      421 elenppllpe stvspqastp isqstpvfpp gslpipsqpq fshdifipsp sleeqsndgk
      481 kdgdmhsssl tvecsktsei epknspedlg lsltgdsckl mlstseysqs pkmeslsshr
      541 idedgentqi edtepmspvl nskfvpaend silmnpaqdg evqlsqnddk tkgddtdtrd
      601 disilatgck greetvaedv cidltcdsgs qavpspatrs ealssvldqe eameikehhp
      661 eegssgseve eipetpcesq geelkeenme svplhlslte tqsqglclqk empkkecsea
      721 mevetsvisi dspqklaild qelehkeqea weeatsedss vvivdvkeps prvdvscepl
      781 egvekcsdsq swediapeie pcaenrldtk eeksveyegd lksgtaetep veqdssqpsl
      841 plvraddplr ldqelqqpqt qektsnslte dskmanakql ssdaeaqklg kpsahasqsf
      901 cesssetpfh ftlpkegdii ppltgatppl ighlklepkr hstpigisny pestiatsdv
      961 msesmvethd pilgsgkgds gaapdvddkl clrmklvspe teaseeslqf nlekpatger
     1021 kngstavaes vaspqktmsv lscicearqe nearsedppt tpirekksli clslhmamsy
     1081 ivt
//
LOCUS       XP_047288957             287 aa            linear   PRI 05-AUG-2025
DEFINITION  tropomyosin alpha-1 chain isoform X1 [Homo sapiens].
ACCESSION   XP_047288957
VERSION     XP_047288957.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433001.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..287
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..287
                     /product="tropomyosin alpha-1 chain isoform X1"
                     /calculated_mol_wt=32901
     Region          48..259
                     /region_name="Tropomyosin"
                     /note="pfam00261"
                     /db_xref="CDD:459736"
     CDS             1..287
                     /gene="TPM1"
                     /gene_synonym="C15orf13; CMD1Y; CMH3; HEL-S-265;
                     HTM-alpha; LVNC9; TMSA"
                     /coded_by="XM_047433001.1:84..947"
                     /db_xref="GeneID:7168"
                     /db_xref="HGNC:HGNC:12010"
                     /db_xref="MIM:191010"
ORIGIN      
        1 mdaikkkmqm lkldkenald raeqaeadkk aaedrskqle ediaakekll rvsederdrv
       61 leelhkaeds llaaeeaaak aeadvaslnr riqlveeeld raqerlatal qkleeaekaa
      121 desergmkvi esraqkdeek meiqeiqlke akhiaedadr kyeevarklv iiesdlerae
      181 eraelsegqv rqleeqlrim dqtlkalmaa edkysqkedr yeeeikvlsd klkeaetrae
      241 faersvtkle ksiddledkf lcftspktps sswmshlsel ciclfss
//
LOCUS       XP_047288962             619 aa            linear   PRI 05-AUG-2025
DEFINITION  golgin subfamily A member 8O isoform X1 [Homo sapiens].
ACCESSION   XP_047288962
VERSION     XP_047288962.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433006.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..619
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..619
                     /product="golgin subfamily A member 8O isoform X1"
                     /calculated_mol_wt=69970
     Region          73..>277
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     Region          213..>466
                     /region_name="GOLGA2L5"
                     /note="Putative golgin subfamily A member 2-like protein
                     5; pfam15070"
                     /db_xref="CDD:464485"
     Region          580..619
                     /region_name="GM130_C"
                     /note="GM130 C-terminal binding motif; pfam19046"
                     /db_xref="CDD:465957"
     CDS             1..619
                     /gene="GOLGA8O"
                     /coded_by="XM_047433006.1:162..2021"
                     /db_xref="GeneID:728047"
                     /db_xref="HGNC:HGNC:44406"
ORIGIN      
        1 mltlkeywqk nrprvpagvn rnrktngsip etatsggcqp pgdsatgfhr egptssatlk
       61 dlespcqera vvldstsvki srlkntiksl kqqkkqvehq leeekkanne rqkaerelev
      121 qiqtliiqke elntdlyhme rslryfeees kdlavrlqhs lqckgelesa lsaviatekk
      181 kanqlsscsk ahteweleqs lqdqallkaq ltqlkesfqq lqlerdecae hiegerarwh
      241 qrmskmsqei ctlkkekqqd mrrveelers lsklknqmae plppeppavp sevelqhlrk
      301 elervagelq sqvknnqhis llnrrqeeri reqeerlrkq eerlqeqhek lrqlakpqsv
      361 feelnnenks tlqleqqvke lqeklgeehl eaasqqnqql taqlslmalp geghggehld
      421 segeeaprpm psvpedpesr eamssfmdhl kekadlselv kkqelrfiqy wqerchqkih
      481 hllsepggra kdaalggghh qagaqggdeg eaagaaadgi aaysnynngh rkflaaahns
      541 adepgpgapa pqelgaadkh gdlrevtlts saqgearedp lldkptaqpi vqdhqehpgl
      601 gsnccvplfc wawlprrrr
//
LOCUS       XP_011520290             609 aa            linear   PRI 05-AUG-2025
DEFINITION  golgin subfamily A member 8O isoform X2 [Homo sapiens].
ACCESSION   XP_011520290
VERSION     XP_011520290.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521988.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..609
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..609
                     /product="golgin subfamily A member 8O isoform X2"
                     /calculated_mol_wt=68723
     Region          86..>290
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     Region          226..>456
                     /region_name="GOLGA2L5"
                     /note="Putative golgin subfamily A member 2-like protein
                     5; pfam15070"
                     /db_xref="CDD:464485"
     Region          570..609
                     /region_name="GM130_C"
                     /note="GM130 C-terminal binding motif; pfam19046"
                     /db_xref="CDD:465957"
     CDS             1..609
                     /gene="GOLGA8O"
                     /coded_by="XM_011521988.4:99..1928"
                     /db_xref="GeneID:728047"
                     /db_xref="HGNC:HGNC:44406"
ORIGIN      
        1 maeetqhnkl aaakkklkey wqknrprvpa gvnrnrktng sipetatsgg cqppgdsatg
       61 fhregptssa tlkdlespcq eravvldsts vkisrlknti kslkqqkkqv ehqleeekka
      121 nnerqkaere levqiqtlii qkeelntdly hmerslryfe eeskdlavrl qhslqckgel
      181 esalsaviat ekkkanqlss cskahtewel eqslqdqall kaqltqlkes fqqlqlerde
      241 caehiegera rwhqrmskms qeictlkkek qqdmrrveel erslsklknq maeplppepp
      301 avpsevelqh lrkelervag elqsqvknnq hisllnrrqe erireqeerl rkqeerlqeq
      361 heklrqlakp qsvfeelehl eaasqqnqql taqlslmalp geghggehld segeeaprpm
      421 psvpedpesr eamssfmdhl kekadlselv kkqelrfiqy wqerchqkih hllsepggra
      481 kdaalggghh qagaqggdeg eaagaaadgi aaysnynngh rkflaaahns adepgpgapa
      541 pqelgaadkh gdlrevtlts saqgearedp lldkptaqpi vqdhqehpgl gsnccvplfc
      601 wawlprrrr
//
LOCUS       XP_024305810             481 aa            linear   PRI 05-AUG-2025
DEFINITION  golgin subfamily A member 8O isoform X3 [Homo sapiens].
ACCESSION   XP_024305810
VERSION     XP_024305810.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024450042.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..481
                     /product="golgin subfamily A member 8O isoform X3"
                     /calculated_mol_wt=54352
     Region          75..>328
                     /region_name="GOLGA2L5"
                     /note="Putative golgin subfamily A member 2-like protein
                     5; pfam15070"
                     /db_xref="CDD:464485"
     Region          442..481
                     /region_name="GM130_C"
                     /note="GM130 C-terminal binding motif; pfam19046"
                     /db_xref="CDD:465957"
     CDS             1..481
                     /gene="GOLGA8O"
                     /coded_by="XM_024450042.2:736..2181"
                     /db_xref="GeneID:728047"
                     /db_xref="HGNC:HGNC:44406"
ORIGIN      
        1 merslryfee eskdlavrlq hslqckgele salsaviate kkkanqlssc skahtewele
       61 qslqdqallk aqltqlkesf qqlqlerdec aehiegerar whqrmskmsq eictlkkekq
      121 qdmrrveele rslsklknqm aeplppeppa vpsevelqhl rkelervage lqsqvknnqh
      181 isllnrrqee rireqeerlr kqeerlqeqh eklrqlakpq svfeelnnen kstlqleqqv
      241 kelqeklgee hleaasqqnq qltaqlslma lpgeghggeh ldsegeeapr pmpsvpedpe
      301 sreamssfmd hlkekadlse lvkkqelrfi qywqerchqk ihhllsepgg rakdaalggg
      361 hhqagaqggd egeaagaaad giaaysnynn ghrkflaaah nsadepgpga papqelgaad
      421 khgdlrevtl tssaqgeare dplldkptaq pivqdhqehp glgsnccvpl fcwawlprrr
      481 r
//
LOCUS       XP_011520291             449 aa            linear   PRI 05-AUG-2025
DEFINITION  golgin subfamily A member 8O isoform X4 [Homo sapiens].
ACCESSION   XP_011520291
VERSION     XP_011520291.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521989.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..449
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..449
                     /product="golgin subfamily A member 8O isoform X4"
                     /calculated_mol_wt=52163
     Region          86..>290
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     Region          226..>449
                     /region_name="GOLGA2L5"
                     /note="Putative golgin subfamily A member 2-like protein
                     5; pfam15070"
                     /db_xref="CDD:464485"
     CDS             1..449
                     /gene="GOLGA8O"
                     /coded_by="XM_011521989.4:99..1448"
                     /db_xref="GeneID:728047"
                     /db_xref="HGNC:HGNC:44406"
ORIGIN      
        1 maeetqhnkl aaakkklkey wqknrprvpa gvnrnrktng sipetatsgg cqppgdsatg
       61 fhregptssa tlkdlespcq eravvldsts vkisrlknti kslkqqkkqv ehqleeekka
      121 nnerqkaere levqiqtlii qkeelntdly hmerslryfe eeskdlavrl qhslqckgel
      181 esalsaviat ekkkanqlss cskahtewel eqslqdqall kaqltqlkes fqqlqlerde
      241 caehiegera rwhqrmskms qeictlkkek qqdmrrveel erslsklknq maeplppepp
      301 avpsevelqh lrkelervag elqsqvknnq hisllnrrqe erireqeerl rkqeerlqeq
      361 heklrqlakp qsvfeelnne nkstlqleqq vkelqeklge velksqeaqs lqqqpdhylg
      421 hlqqyvatyq qqvaayqqlt cekealyrq
//
LOCUS       XP_016878032             771 aa            linear   PRI 05-AUG-2025
DEFINITION  tyrosine-protein kinase receptor TYRO3 isoform X1 [Homo sapiens].
ACCESSION   XP_016878032
VERSION     XP_016878032.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022543.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..771
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..771
                     /product="tyrosine-protein kinase receptor TYRO3 isoform
                     X1"
                     /calculated_mol_wt=83994
     Region          50..136
                     /region_name="Ig1_Tyro3_like"
                     /note="First immunoglobulin (Ig)-like domain of Tyro3
                     receptor tyrosine kinase (RTK), and similar domains;
                     cd20961"
                     /db_xref="CDD:409553"
     Region          50..55
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409553"
     Region          58..67
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409553"
     Region          73..78
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409553"
     Region          81..83
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409553"
     Region          87..92
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409553"
     Region          97..104
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409553"
     Region          113..119
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409553"
     Region          125..136
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409553"
     Region          140..220
                     /region_name="IgI_2_Axl_Tyro3_like"
                     /note="Second immunoglobulin (Ig)-like domain of Axl/Tyro3
                     family receptor tyrosine kinases (RTKs); member of the
                     I-set of Ig superfamily (IgSF) domains; cd05749"
                     /db_xref="CDD:409407"
     Region          140..143
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409407"
     Region          146..150
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409407"
     Region          154..163
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409407"
     Region          168..175
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409407"
     Region          177..180
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409407"
     Region          184..195
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409407"
     Region          198..207
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409407"
     Site            206..211
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:409407"
     Site            order(209..211,213)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:409407"
     Region          211..220
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409407"
     Region          225..317
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(225,290,305)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Site            order(306..307,309..310)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          324..406
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(402..403,405..406)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          508..766
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Site            order(524..527,530,532,548,550,581,603..606,655,659..660,
                     662,672..673)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270659"
     CDS             1..771
                     /gene="TYRO3"
                     /gene_synonym="BYK; Dtk; Etk-2; Rek; RSE; Sky; Tif"
                     /coded_by="XM_017022543.3:47..2362"
                     /db_xref="GeneID:7301"
                     /db_xref="HGNC:HGNC:12446"
                     /db_xref="MIM:600341"
ORIGIN      
        1 malrrsmgrp glpplplppp prlglllaal aslllpesaa aglklmgapv kltvsqgqpv
       61 klncsvegme epdiqwvkdg avvqnldqly ipvseqhwig flslksvers dagrywcqve
      121 dggeteisqp vwltvegvpf ftvepkdlav ppnapfqlsc eavgppepvt ivwwrgttki
      181 ggpapspsvl nvtgvtqstm fsceahnlkg lassrtatvh lqalpaapfn itvtklsssn
      241 asvawmpgad grallqsctv qvtqapggwe vlavvvpvpp ftcllrdlvp atnyslrvrc
      301 analgpspya dwvpfqtkgl apasapqnlh airtdsglil eweevipeap legplgpykl
      361 swvqdngtqd eltvegtran ltgwdpqkdl ivrvcvsnav gcgpwsqplv vsshdragqq
      421 gpphsrtswv pvvlgvltal vtaaalalil lrkrrketrf gqafdsvmar gepavhfraa
      481 rsfnrerper ieatldslgi sdelkekled vlipeqqftl grmlgkgefg svreaqlkqe
      541 dgsfvkvavk mlkadiiass dieeflreaa cmkefdhphv aklvgvslrs rakgrlpipm
      601 vilpfmkhgd lhafllasri genpfnlplq tlirfmvdia cgmeylssrn fihrdlaarn
      661 cmlaedmtvc vadfglsrki ysgdyyrqgc asklpvkwla lesladnlyt vqsdvwafgv
      721 tmweimtrgq tpyagienae iynyliggnr lkqppecmed veynlcpgdp s
//
LOCUS       XP_047288963             875 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin-protein ligase E3A isoform X1 [Homo sapiens].
ACCESSION   XP_047288963
VERSION     XP_047288963.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433007.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..875
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..875
                     /product="ubiquitin-protein ligase E3A isoform X1"
                     /calculated_mol_wt=100557
     Region          29..83
                     /region_name="AZUL"
                     /note="Amino-terminal Zinc-binding domain of ubiquitin
                     ligase E3A; pfam16558"
                     /db_xref="CDD:465173"
     Region          523..873
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(529,562,573,630,808,837..838,841..845,865,872)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(658,661..662,664..665,668,676,678,682..683,685,691,
                     696,713,717)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..875
                     /gene="UBE3A"
                     /gene_synonym="ANCR; AS; E6-AP; EPVE6AP; HPVE6A; PIX1"
                     /coded_by="XM_047433007.1:451..3078"
                     /db_xref="GeneID:7337"
                     /db_xref="HGNC:HGNC:12496"
                     /db_xref="MIM:601623"
ORIGIN      
        1 meklhqcywk sgepqsddie asrmkraaak hlieryyhql tegcgneact nefcascptf
       61 lrmdnnaaai kalelykina klcdphpskk gassaylens kgapnnscse ikmnkkgari
      121 dfkdvtylte ekvyeilelc reredyspli rvigrvfssa ealvqsfrkv kqhtkeelks
      181 lqakdedkde dekekaacsa aameedseas ssrigdssqg dnnlqklgpd dvsvdidair
      241 rvytrllsne kietaflnal vylspnvecd ltyhnvysrd pnylnlfiiv menrnlhspe
      301 ylemalplfc kamsklplaa qgklirlwsk ynadqirrmm etfqqlityk visnefnsrn
      361 lvndddaiva askclkmvyy anvvggevdt nhneeddeep ipesseltlq ellgeerrnk
      421 kgprvdplet elgvktldcr kplipfeefi neplnevlem dkdytffkve tenkfsfmtc
      481 pfilnavtkn lglyydnrir myserritvl yslvqgqqln pylrlkvrrd hiiddalvrl
      541 emiamenpad lkkqlyvefe geqgvdeggv skeffqlvve eifnpdigmf tydestklfw
      601 fnpssfeteg qftligivlg laiynncild vhfpmvvyrk lmgkkgtfrd lgdshpvlyq
      661 slkdlleyeg nveddmmitf qisqtdlfgn pmmydlkeng dkipitnenr kefvnlysdy
      721 ilnksvekqf kafrrgfhmv tnesplkylf rpeeiellic gsrnldfqal eetteydggy
      781 trdsvliref weivhsftde qkrlflqftt gtdrapvggl gklkmiiakn gpdterlpts
      841 htcfnvlllp eysskeklke rllkaityak gfgml
//
LOCUS       XP_024305811             875 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin-protein ligase E3A isoform X1 [Homo sapiens].
ACCESSION   XP_024305811
VERSION     XP_024305811.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024450043.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..875
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..875
                     /product="ubiquitin-protein ligase E3A isoform X1"
                     /calculated_mol_wt=100557
     Region          29..83
                     /region_name="AZUL"
                     /note="Amino-terminal Zinc-binding domain of ubiquitin
                     ligase E3A; pfam16558"
                     /db_xref="CDD:465173"
     Region          523..873
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(529,562,573,630,808,837..838,841..845,865,872)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(658,661..662,664..665,668,676,678,682..683,685,691,
                     696,713,717)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..875
                     /gene="UBE3A"
                     /gene_synonym="ANCR; AS; E6-AP; EPVE6AP; HPVE6A; PIX1"
                     /coded_by="XM_024450043.2:446..3073"
                     /db_xref="GeneID:7337"
                     /db_xref="HGNC:HGNC:12496"
                     /db_xref="MIM:601623"
ORIGIN      
        1 meklhqcywk sgepqsddie asrmkraaak hlieryyhql tegcgneact nefcascptf
       61 lrmdnnaaai kalelykina klcdphpskk gassaylens kgapnnscse ikmnkkgari
      121 dfkdvtylte ekvyeilelc reredyspli rvigrvfssa ealvqsfrkv kqhtkeelks
      181 lqakdedkde dekekaacsa aameedseas ssrigdssqg dnnlqklgpd dvsvdidair
      241 rvytrllsne kietaflnal vylspnvecd ltyhnvysrd pnylnlfiiv menrnlhspe
      301 ylemalplfc kamsklplaa qgklirlwsk ynadqirrmm etfqqlityk visnefnsrn
      361 lvndddaiva askclkmvyy anvvggevdt nhneeddeep ipesseltlq ellgeerrnk
      421 kgprvdplet elgvktldcr kplipfeefi neplnevlem dkdytffkve tenkfsfmtc
      481 pfilnavtkn lglyydnrir myserritvl yslvqgqqln pylrlkvrrd hiiddalvrl
      541 emiamenpad lkkqlyvefe geqgvdeggv skeffqlvve eifnpdigmf tydestklfw
      601 fnpssfeteg qftligivlg laiynncild vhfpmvvyrk lmgkkgtfrd lgdshpvlyq
      661 slkdlleyeg nveddmmitf qisqtdlfgn pmmydlkeng dkipitnenr kefvnlysdy
      721 ilnksvekqf kafrrgfhmv tnesplkylf rpeeiellic gsrnldfqal eetteydggy
      781 trdsvliref weivhsftde qkrlflqftt gtdrapvggl gklkmiiakn gpdterlpts
      841 htcfnvlllp eysskeklke rllkaityak gfgml
//
LOCUS       XP_011520297             875 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin-protein ligase E3A isoform X1 [Homo sapiens].
ACCESSION   XP_011520297
VERSION     XP_011520297.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011521995.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..875
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..875
                     /product="ubiquitin-protein ligase E3A isoform X1"
                     /calculated_mol_wt=100557
     Region          29..83
                     /region_name="AZUL"
                     /note="Amino-terminal Zinc-binding domain of ubiquitin
                     ligase E3A; pfam16558"
                     /db_xref="CDD:465173"
     Region          523..873
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(529,562,573,630,808,837..838,841..845,865,872)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(658,661..662,664..665,668,676,678,682..683,685,691,
                     696,713,717)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..875
                     /gene="UBE3A"
                     /gene_synonym="ANCR; AS; E6-AP; EPVE6AP; HPVE6A; PIX1"
                     /coded_by="XM_011521995.4:626..3253"
                     /db_xref="GeneID:7337"
                     /db_xref="HGNC:HGNC:12496"
                     /db_xref="MIM:601623"
ORIGIN      
        1 meklhqcywk sgepqsddie asrmkraaak hlieryyhql tegcgneact nefcascptf
       61 lrmdnnaaai kalelykina klcdphpskk gassaylens kgapnnscse ikmnkkgari
      121 dfkdvtylte ekvyeilelc reredyspli rvigrvfssa ealvqsfrkv kqhtkeelks
      181 lqakdedkde dekekaacsa aameedseas ssrigdssqg dnnlqklgpd dvsvdidair
      241 rvytrllsne kietaflnal vylspnvecd ltyhnvysrd pnylnlfiiv menrnlhspe
      301 ylemalplfc kamsklplaa qgklirlwsk ynadqirrmm etfqqlityk visnefnsrn
      361 lvndddaiva askclkmvyy anvvggevdt nhneeddeep ipesseltlq ellgeerrnk
      421 kgprvdplet elgvktldcr kplipfeefi neplnevlem dkdytffkve tenkfsfmtc
      481 pfilnavtkn lglyydnrir myserritvl yslvqgqqln pylrlkvrrd hiiddalvrl
      541 emiamenpad lkkqlyvefe geqgvdeggv skeffqlvve eifnpdigmf tydestklfw
      601 fnpssfeteg qftligivlg laiynncild vhfpmvvyrk lmgkkgtfrd lgdshpvlyq
      661 slkdlleyeg nveddmmitf qisqtdlfgn pmmydlkeng dkipitnenr kefvnlysdy
      721 ilnksvekqf kafrrgfhmv tnesplkylf rpeeiellic gsrnldfqal eetteydggy
      781 trdsvliref weivhsftde qkrlflqftt gtdrapvggl gklkmiiakn gpdterlpts
      841 htcfnvlllp eysskeklke rllkaityak gfgml
//
LOCUS       XP_047288964             875 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin-protein ligase E3A isoform X1 [Homo sapiens].
ACCESSION   XP_047288964
VERSION     XP_047288964.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433008.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..875
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..875
                     /product="ubiquitin-protein ligase E3A isoform X1"
                     /calculated_mol_wt=100557
     Region          29..83
                     /region_name="AZUL"
                     /note="Amino-terminal Zinc-binding domain of ubiquitin
                     ligase E3A; pfam16558"
                     /db_xref="CDD:465173"
     Region          523..873
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(529,562,573,630,808,837..838,841..845,865,872)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(658,661..662,664..665,668,676,678,682..683,685,691,
                     696,713,717)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..875
                     /gene="UBE3A"
                     /gene_synonym="ANCR; AS; E6-AP; EPVE6AP; HPVE6A; PIX1"
                     /coded_by="XM_047433008.1:922..3549"
                     /db_xref="GeneID:7337"
                     /db_xref="HGNC:HGNC:12496"
                     /db_xref="MIM:601623"
ORIGIN      
        1 meklhqcywk sgepqsddie asrmkraaak hlieryyhql tegcgneact nefcascptf
       61 lrmdnnaaai kalelykina klcdphpskk gassaylens kgapnnscse ikmnkkgari
      121 dfkdvtylte ekvyeilelc reredyspli rvigrvfssa ealvqsfrkv kqhtkeelks
      181 lqakdedkde dekekaacsa aameedseas ssrigdssqg dnnlqklgpd dvsvdidair
      241 rvytrllsne kietaflnal vylspnvecd ltyhnvysrd pnylnlfiiv menrnlhspe
      301 ylemalplfc kamsklplaa qgklirlwsk ynadqirrmm etfqqlityk visnefnsrn
      361 lvndddaiva askclkmvyy anvvggevdt nhneeddeep ipesseltlq ellgeerrnk
      421 kgprvdplet elgvktldcr kplipfeefi neplnevlem dkdytffkve tenkfsfmtc
      481 pfilnavtkn lglyydnrir myserritvl yslvqgqqln pylrlkvrrd hiiddalvrl
      541 emiamenpad lkkqlyvefe geqgvdeggv skeffqlvve eifnpdigmf tydestklfw
      601 fnpssfeteg qftligivlg laiynncild vhfpmvvyrk lmgkkgtfrd lgdshpvlyq
      661 slkdlleyeg nveddmmitf qisqtdlfgn pmmydlkeng dkipitnenr kefvnlysdy
      721 ilnksvekqf kafrrgfhmv tnesplkylf rpeeiellic gsrnldfqal eetteydggy
      781 trdsvliref weivhsftde qkrlflqftt gtdrapvggl gklkmiiakn gpdterlpts
      841 htcfnvlllp eysskeklke rllkaityak gfgml
//
LOCUS       XP_047288965             875 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin-protein ligase E3A isoform X1 [Homo sapiens].
ACCESSION   XP_047288965
VERSION     XP_047288965.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433009.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..875
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..875
                     /product="ubiquitin-protein ligase E3A isoform X1"
                     /calculated_mol_wt=100557
     Region          29..83
                     /region_name="AZUL"
                     /note="Amino-terminal Zinc-binding domain of ubiquitin
                     ligase E3A; pfam16558"
                     /db_xref="CDD:465173"
     Region          523..873
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(529,562,573,630,808,837..838,841..845,865,872)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(658,661..662,664..665,668,676,678,682..683,685,691,
                     696,713,717)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..875
                     /gene="UBE3A"
                     /gene_synonym="ANCR; AS; E6-AP; EPVE6AP; HPVE6A; PIX1"
                     /coded_by="XM_047433009.1:1826..4453"
                     /db_xref="GeneID:7337"
                     /db_xref="HGNC:HGNC:12496"
                     /db_xref="MIM:601623"
ORIGIN      
        1 meklhqcywk sgepqsddie asrmkraaak hlieryyhql tegcgneact nefcascptf
       61 lrmdnnaaai kalelykina klcdphpskk gassaylens kgapnnscse ikmnkkgari
      121 dfkdvtylte ekvyeilelc reredyspli rvigrvfssa ealvqsfrkv kqhtkeelks
      181 lqakdedkde dekekaacsa aameedseas ssrigdssqg dnnlqklgpd dvsvdidair
      241 rvytrllsne kietaflnal vylspnvecd ltyhnvysrd pnylnlfiiv menrnlhspe
      301 ylemalplfc kamsklplaa qgklirlwsk ynadqirrmm etfqqlityk visnefnsrn
      361 lvndddaiva askclkmvyy anvvggevdt nhneeddeep ipesseltlq ellgeerrnk
      421 kgprvdplet elgvktldcr kplipfeefi neplnevlem dkdytffkve tenkfsfmtc
      481 pfilnavtkn lglyydnrir myserritvl yslvqgqqln pylrlkvrrd hiiddalvrl
      541 emiamenpad lkkqlyvefe geqgvdeggv skeffqlvve eifnpdigmf tydestklfw
      601 fnpssfeteg qftligivlg laiynncild vhfpmvvyrk lmgkkgtfrd lgdshpvlyq
      661 slkdlleyeg nveddmmitf qisqtdlfgn pmmydlkeng dkipitnenr kefvnlysdy
      721 ilnksvekqf kafrrgfhmv tnesplkylf rpeeiellic gsrnldfqal eetteydggy
      781 trdsvliref weivhsftde qkrlflqftt gtdrapvggl gklkmiiakn gpdterlpts
      841 htcfnvlllp eysskeklke rllkaityak gfgml
//
LOCUS       XP_047288966             875 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin-protein ligase E3A isoform X1 [Homo sapiens].
ACCESSION   XP_047288966
VERSION     XP_047288966.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433010.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..875
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..875
                     /product="ubiquitin-protein ligase E3A isoform X1"
                     /calculated_mol_wt=100557
     Region          29..83
                     /region_name="AZUL"
                     /note="Amino-terminal Zinc-binding domain of ubiquitin
                     ligase E3A; pfam16558"
                     /db_xref="CDD:465173"
     Region          523..873
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(529,562,573,630,808,837..838,841..845,865,872)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(658,661..662,664..665,668,676,678,682..683,685,691,
                     696,713,717)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..875
                     /gene="UBE3A"
                     /gene_synonym="ANCR; AS; E6-AP; EPVE6AP; HPVE6A; PIX1"
                     /coded_by="XM_047433010.1:257..2884"
                     /db_xref="GeneID:7337"
                     /db_xref="HGNC:HGNC:12496"
                     /db_xref="MIM:601623"
ORIGIN      
        1 meklhqcywk sgepqsddie asrmkraaak hlieryyhql tegcgneact nefcascptf
       61 lrmdnnaaai kalelykina klcdphpskk gassaylens kgapnnscse ikmnkkgari
      121 dfkdvtylte ekvyeilelc reredyspli rvigrvfssa ealvqsfrkv kqhtkeelks
      181 lqakdedkde dekekaacsa aameedseas ssrigdssqg dnnlqklgpd dvsvdidair
      241 rvytrllsne kietaflnal vylspnvecd ltyhnvysrd pnylnlfiiv menrnlhspe
      301 ylemalplfc kamsklplaa qgklirlwsk ynadqirrmm etfqqlityk visnefnsrn
      361 lvndddaiva askclkmvyy anvvggevdt nhneeddeep ipesseltlq ellgeerrnk
      421 kgprvdplet elgvktldcr kplipfeefi neplnevlem dkdytffkve tenkfsfmtc
      481 pfilnavtkn lglyydnrir myserritvl yslvqgqqln pylrlkvrrd hiiddalvrl
      541 emiamenpad lkkqlyvefe geqgvdeggv skeffqlvve eifnpdigmf tydestklfw
      601 fnpssfeteg qftligivlg laiynncild vhfpmvvyrk lmgkkgtfrd lgdshpvlyq
      661 slkdlleyeg nveddmmitf qisqtdlfgn pmmydlkeng dkipitnenr kefvnlysdy
      721 ilnksvekqf kafrrgfhmv tnesplkylf rpeeiellic gsrnldfqal eetteydggy
      781 trdsvliref weivhsftde qkrlflqftt gtdrapvggl gklkmiiakn gpdterlpts
      841 htcfnvlllp eysskeklke rllkaityak gfgml
//
LOCUS       XP_016878036             872 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin-protein ligase E3A isoform X2 [Homo sapiens].
ACCESSION   XP_016878036
VERSION     XP_016878036.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022547.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..872
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..872
                     /product="ubiquitin-protein ligase E3A isoform X2"
                     /calculated_mol_wt=99971
     Region          26..80
                     /region_name="AZUL"
                     /note="Amino-terminal Zinc-binding domain of ubiquitin
                     ligase E3A; pfam16558"
                     /db_xref="CDD:465173"
     Region          520..870
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(526,559,570,627,805,834..835,838..842,862,869)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(655,658..659,661..662,665,673,675,679..680,682,688,
                     693,710,714)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..872
                     /gene="UBE3A"
                     /gene_synonym="ANCR; AS; E6-AP; EPVE6AP; HPVE6A; PIX1"
                     /coded_by="XM_017022547.3:866..3484"
                     /db_xref="GeneID:7337"
                     /db_xref="HGNC:HGNC:12496"
                     /db_xref="MIM:601623"
ORIGIN      
        1 matackrsge pqsddieasr mkraaakhli eryyhqlteg cgneactnef cascptflrm
       61 dnnaaaikal elykinaklc dphpskkgas saylenskga pnnscseikm nkkgaridfk
      121 dvtylteekv yeilelcrer edysplirvi grvfssaeal vqsfrkvkqh tkeelkslqa
      181 kdedkdedek ekaacsaaam eedseasssr igdssqgdnn lqklgpddvs vdidairrvy
      241 trllsnekie taflnalvyl spnvecdlty hnvysrdpny lnlfiivmen rnlhspeyle
      301 malplfckam sklplaaqgk lirlwskyna dqirrmmetf qqlitykvis nefnsrnlvn
      361 dddaivaask clkmvyyanv vggevdtnhn eeddeepipe sseltlqell geerrnkkgp
      421 rvdpletelg vktldcrkpl ipfeefinep lnevlemdkd ytffkveten kfsfmtcpfi
      481 lnavtknlgl yydnrirmys erritvlysl vqgqqlnpyl rlkvrrdhii ddalvrlemi
      541 amenpadlkk qlyvefegeq gvdeggvske ffqlvveeif npdigmftyd estklfwfnp
      601 ssfetegqft ligivlglai ynncildvhf pmvvyrklmg kkgtfrdlgd shpvlyqslk
      661 dlleyegnve ddmmitfqis qtdlfgnpmm ydlkengdki pitnenrkef vnlysdyiln
      721 ksvekqfkaf rrgfhmvtne splkylfrpe eiellicgsr nldfqaleet teydggytrd
      781 svlirefwei vhsftdeqkr lflqfttgtd rapvgglgkl kmiiakngpd terlptshtc
      841 fnvlllpeys skeklkerll kaityakgfg ml
//
LOCUS       XP_047288967             872 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin-protein ligase E3A isoform X2 [Homo sapiens].
ACCESSION   XP_047288967
VERSION     XP_047288967.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433011.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..872
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..872
                     /product="ubiquitin-protein ligase E3A isoform X2"
                     /calculated_mol_wt=99971
     Region          26..80
                     /region_name="AZUL"
                     /note="Amino-terminal Zinc-binding domain of ubiquitin
                     ligase E3A; pfam16558"
                     /db_xref="CDD:465173"
     Region          520..870
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(526,559,570,627,805,834..835,838..842,862,869)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(655,658..659,661..662,665,673,675,679..680,682,688,
                     693,710,714)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..872
                     /gene="UBE3A"
                     /gene_synonym="ANCR; AS; E6-AP; EPVE6AP; HPVE6A; PIX1"
                     /coded_by="XM_047433011.1:395..3013"
                     /db_xref="GeneID:7337"
                     /db_xref="HGNC:HGNC:12496"
                     /db_xref="MIM:601623"
ORIGIN      
        1 matackrsge pqsddieasr mkraaakhli eryyhqlteg cgneactnef cascptflrm
       61 dnnaaaikal elykinaklc dphpskkgas saylenskga pnnscseikm nkkgaridfk
      121 dvtylteekv yeilelcrer edysplirvi grvfssaeal vqsfrkvkqh tkeelkslqa
      181 kdedkdedek ekaacsaaam eedseasssr igdssqgdnn lqklgpddvs vdidairrvy
      241 trllsnekie taflnalvyl spnvecdlty hnvysrdpny lnlfiivmen rnlhspeyle
      301 malplfckam sklplaaqgk lirlwskyna dqirrmmetf qqlitykvis nefnsrnlvn
      361 dddaivaask clkmvyyanv vggevdtnhn eeddeepipe sseltlqell geerrnkkgp
      421 rvdpletelg vktldcrkpl ipfeefinep lnevlemdkd ytffkveten kfsfmtcpfi
      481 lnavtknlgl yydnrirmys erritvlysl vqgqqlnpyl rlkvrrdhii ddalvrlemi
      541 amenpadlkk qlyvefegeq gvdeggvske ffqlvveeif npdigmftyd estklfwfnp
      601 ssfetegqft ligivlglai ynncildvhf pmvvyrklmg kkgtfrdlgd shpvlyqslk
      661 dlleyegnve ddmmitfqis qtdlfgnpmm ydlkengdki pitnenrkef vnlysdyiln
      721 ksvekqfkaf rrgfhmvtne splkylfrpe eiellicgsr nldfqaleet teydggytrd
      781 svlirefwei vhsftdeqkr lflqfttgtd rapvgglgkl kmiiakngpd terlptshtc
      841 fnvlllpeys skeklkerll kaityakgfg ml
//
LOCUS       XP_047288968             872 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin-protein ligase E3A isoform X2 [Homo sapiens].
ACCESSION   XP_047288968
VERSION     XP_047288968.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433012.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..872
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..872
                     /product="ubiquitin-protein ligase E3A isoform X2"
                     /calculated_mol_wt=99971
     Region          26..80
                     /region_name="AZUL"
                     /note="Amino-terminal Zinc-binding domain of ubiquitin
                     ligase E3A; pfam16558"
                     /db_xref="CDD:465173"
     Region          520..870
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(526,559,570,627,805,834..835,838..842,862,869)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(655,658..659,661..662,665,673,675,679..680,682,688,
                     693,710,714)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..872
                     /gene="UBE3A"
                     /gene_synonym="ANCR; AS; E6-AP; EPVE6AP; HPVE6A; PIX1"
                     /coded_by="XM_047433012.1:334..2952"
                     /db_xref="GeneID:7337"
                     /db_xref="HGNC:HGNC:12496"
                     /db_xref="MIM:601623"
ORIGIN      
        1 matackrsge pqsddieasr mkraaakhli eryyhqlteg cgneactnef cascptflrm
       61 dnnaaaikal elykinaklc dphpskkgas saylenskga pnnscseikm nkkgaridfk
      121 dvtylteekv yeilelcrer edysplirvi grvfssaeal vqsfrkvkqh tkeelkslqa
      181 kdedkdedek ekaacsaaam eedseasssr igdssqgdnn lqklgpddvs vdidairrvy
      241 trllsnekie taflnalvyl spnvecdlty hnvysrdpny lnlfiivmen rnlhspeyle
      301 malplfckam sklplaaqgk lirlwskyna dqirrmmetf qqlitykvis nefnsrnlvn
      361 dddaivaask clkmvyyanv vggevdtnhn eeddeepipe sseltlqell geerrnkkgp
      421 rvdpletelg vktldcrkpl ipfeefinep lnevlemdkd ytffkveten kfsfmtcpfi
      481 lnavtknlgl yydnrirmys erritvlysl vqgqqlnpyl rlkvrrdhii ddalvrlemi
      541 amenpadlkk qlyvefegeq gvdeggvske ffqlvveeif npdigmftyd estklfwfnp
      601 ssfetegqft ligivlglai ynncildvhf pmvvyrklmg kkgtfrdlgd shpvlyqslk
      661 dlleyegnve ddmmitfqis qtdlfgnpmm ydlkengdki pitnenrkef vnlysdyiln
      721 ksvekqfkaf rrgfhmvtne splkylfrpe eiellicgsr nldfqaleet teydggytrd
      781 svlirefwei vhsftdeqkr lflqfttgtd rapvgglgkl kmiiakngpd terlptshtc
      841 fnvlllpeys skeklkerll kaityakgfg ml
//
LOCUS       XP_016878037             872 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin-protein ligase E3A isoform X2 [Homo sapiens].
ACCESSION   XP_016878037
VERSION     XP_016878037.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022548.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..872
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..872
                     /product="ubiquitin-protein ligase E3A isoform X2"
                     /calculated_mol_wt=99971
     Region          26..80
                     /region_name="AZUL"
                     /note="Amino-terminal Zinc-binding domain of ubiquitin
                     ligase E3A; pfam16558"
                     /db_xref="CDD:465173"
     Region          520..870
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(526,559,570,627,805,834..835,838..842,862,869)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(655,658..659,661..662,665,673,675,679..680,682,688,
                     693,710,714)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..872
                     /gene="UBE3A"
                     /gene_synonym="ANCR; AS; E6-AP; EPVE6AP; HPVE6A; PIX1"
                     /coded_by="XM_017022548.3:861..3479"
                     /db_xref="GeneID:7337"
                     /db_xref="HGNC:HGNC:12496"
                     /db_xref="MIM:601623"
ORIGIN      
        1 matackrsge pqsddieasr mkraaakhli eryyhqlteg cgneactnef cascptflrm
       61 dnnaaaikal elykinaklc dphpskkgas saylenskga pnnscseikm nkkgaridfk
      121 dvtylteekv yeilelcrer edysplirvi grvfssaeal vqsfrkvkqh tkeelkslqa
      181 kdedkdedek ekaacsaaam eedseasssr igdssqgdnn lqklgpddvs vdidairrvy
      241 trllsnekie taflnalvyl spnvecdlty hnvysrdpny lnlfiivmen rnlhspeyle
      301 malplfckam sklplaaqgk lirlwskyna dqirrmmetf qqlitykvis nefnsrnlvn
      361 dddaivaask clkmvyyanv vggevdtnhn eeddeepipe sseltlqell geerrnkkgp
      421 rvdpletelg vktldcrkpl ipfeefinep lnevlemdkd ytffkveten kfsfmtcpfi
      481 lnavtknlgl yydnrirmys erritvlysl vqgqqlnpyl rlkvrrdhii ddalvrlemi
      541 amenpadlkk qlyvefegeq gvdeggvske ffqlvveeif npdigmftyd estklfwfnp
      601 ssfetegqft ligivlglai ynncildvhf pmvvyrklmg kkgtfrdlgd shpvlyqslk
      661 dlleyegnve ddmmitfqis qtdlfgnpmm ydlkengdki pitnenrkef vnlysdyiln
      721 ksvekqfkaf rrgfhmvtne splkylfrpe eiellicgsr nldfqaleet teydggytrd
      781 svlirefwei vhsftdeqkr lflqfttgtd rapvgglgkl kmiiakngpd terlptshtc
      841 fnvlllpeys skeklkerll kaityakgfg ml
//
LOCUS       XP_047288969             872 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin-protein ligase E3A isoform X2 [Homo sapiens].
ACCESSION   XP_047288969
VERSION     XP_047288969.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433013.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..872
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..872
                     /product="ubiquitin-protein ligase E3A isoform X2"
                     /calculated_mol_wt=99971
     Region          26..80
                     /region_name="AZUL"
                     /note="Amino-terminal Zinc-binding domain of ubiquitin
                     ligase E3A; pfam16558"
                     /db_xref="CDD:465173"
     Region          520..870
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(526,559,570,627,805,834..835,838..842,862,869)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(655,658..659,661..662,665,673,675,679..680,682,688,
                     693,710,714)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..872
                     /gene="UBE3A"
                     /gene_synonym="ANCR; AS; E6-AP; EPVE6AP; HPVE6A; PIX1"
                     /coded_by="XM_047433013.1:390..3008"
                     /db_xref="GeneID:7337"
                     /db_xref="HGNC:HGNC:12496"
                     /db_xref="MIM:601623"
ORIGIN      
        1 matackrsge pqsddieasr mkraaakhli eryyhqlteg cgneactnef cascptflrm
       61 dnnaaaikal elykinaklc dphpskkgas saylenskga pnnscseikm nkkgaridfk
      121 dvtylteekv yeilelcrer edysplirvi grvfssaeal vqsfrkvkqh tkeelkslqa
      181 kdedkdedek ekaacsaaam eedseasssr igdssqgdnn lqklgpddvs vdidairrvy
      241 trllsnekie taflnalvyl spnvecdlty hnvysrdpny lnlfiivmen rnlhspeyle
      301 malplfckam sklplaaqgk lirlwskyna dqirrmmetf qqlitykvis nefnsrnlvn
      361 dddaivaask clkmvyyanv vggevdtnhn eeddeepipe sseltlqell geerrnkkgp
      421 rvdpletelg vktldcrkpl ipfeefinep lnevlemdkd ytffkveten kfsfmtcpfi
      481 lnavtknlgl yydnrirmys erritvlysl vqgqqlnpyl rlkvrrdhii ddalvrlemi
      541 amenpadlkk qlyvefegeq gvdeggvske ffqlvveeif npdigmftyd estklfwfnp
      601 ssfetegqft ligivlglai ynncildvhf pmvvyrklmg kkgtfrdlgd shpvlyqslk
      661 dlleyegnve ddmmitfqis qtdlfgnpmm ydlkengdki pitnenrkef vnlysdyiln
      721 ksvekqfkaf rrgfhmvtne splkylfrpe eiellicgsr nldfqaleet teydggytrd
      781 svlirefwei vhsftdeqkr lflqfttgtd rapvgglgkl kmiiakngpd terlptshtc
      841 fnvlllpeys skeklkerll kaityakgfg ml
//
LOCUS       XP_047288970             872 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin-protein ligase E3A isoform X2 [Homo sapiens].
ACCESSION   XP_047288970
VERSION     XP_047288970.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433014.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..872
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..872
                     /product="ubiquitin-protein ligase E3A isoform X2"
                     /calculated_mol_wt=99971
     Region          26..80
                     /region_name="AZUL"
                     /note="Amino-terminal Zinc-binding domain of ubiquitin
                     ligase E3A; pfam16558"
                     /db_xref="CDD:465173"
     Region          520..870
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(526,559,570,627,805,834..835,838..842,862,869)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(655,658..659,661..662,665,673,675,679..680,682,688,
                     693,710,714)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..872
                     /gene="UBE3A"
                     /gene_synonym="ANCR; AS; E6-AP; EPVE6AP; HPVE6A; PIX1"
                     /coded_by="XM_047433014.1:329..2947"
                     /db_xref="GeneID:7337"
                     /db_xref="HGNC:HGNC:12496"
                     /db_xref="MIM:601623"
ORIGIN      
        1 matackrsge pqsddieasr mkraaakhli eryyhqlteg cgneactnef cascptflrm
       61 dnnaaaikal elykinaklc dphpskkgas saylenskga pnnscseikm nkkgaridfk
      121 dvtylteekv yeilelcrer edysplirvi grvfssaeal vqsfrkvkqh tkeelkslqa
      181 kdedkdedek ekaacsaaam eedseasssr igdssqgdnn lqklgpddvs vdidairrvy
      241 trllsnekie taflnalvyl spnvecdlty hnvysrdpny lnlfiivmen rnlhspeyle
      301 malplfckam sklplaaqgk lirlwskyna dqirrmmetf qqlitykvis nefnsrnlvn
      361 dddaivaask clkmvyyanv vggevdtnhn eeddeepipe sseltlqell geerrnkkgp
      421 rvdpletelg vktldcrkpl ipfeefinep lnevlemdkd ytffkveten kfsfmtcpfi
      481 lnavtknlgl yydnrirmys erritvlysl vqgqqlnpyl rlkvrrdhii ddalvrlemi
      541 amenpadlkk qlyvefegeq gvdeggvske ffqlvveeif npdigmftyd estklfwfnp
      601 ssfetegqft ligivlglai ynncildvhf pmvvyrklmg kkgtfrdlgd shpvlyqslk
      661 dlleyegnve ddmmitfqis qtdlfgnpmm ydlkengdki pitnenrkef vnlysdyiln
      721 ksvekqfkaf rrgfhmvtne splkylfrpe eiellicgsr nldfqaleet teydggytrd
      781 svlirefwei vhsftdeqkr lflqfttgtd rapvgglgkl kmiiakngpd terlptshtc
      841 fnvlllpeys skeklkerll kaityakgfg ml
//
LOCUS       XP_047288971             872 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin-protein ligase E3A isoform X2 [Homo sapiens].
ACCESSION   XP_047288971
VERSION     XP_047288971.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433015.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..872
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..872
                     /product="ubiquitin-protein ligase E3A isoform X2"
                     /calculated_mol_wt=99971
     Region          26..80
                     /region_name="AZUL"
                     /note="Amino-terminal Zinc-binding domain of ubiquitin
                     ligase E3A; pfam16558"
                     /db_xref="CDD:465173"
     Region          520..870
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(526,559,570,627,805,834..835,838..842,862,869)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(655,658..659,661..662,665,673,675,679..680,682,688,
                     693,710,714)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..872
                     /gene="UBE3A"
                     /gene_synonym="ANCR; AS; E6-AP; EPVE6AP; HPVE6A; PIX1"
                     /coded_by="XM_047433015.1:450..3068"
                     /db_xref="GeneID:7337"
                     /db_xref="HGNC:HGNC:12496"
                     /db_xref="MIM:601623"
ORIGIN      
        1 matackrsge pqsddieasr mkraaakhli eryyhqlteg cgneactnef cascptflrm
       61 dnnaaaikal elykinaklc dphpskkgas saylenskga pnnscseikm nkkgaridfk
      121 dvtylteekv yeilelcrer edysplirvi grvfssaeal vqsfrkvkqh tkeelkslqa
      181 kdedkdedek ekaacsaaam eedseasssr igdssqgdnn lqklgpddvs vdidairrvy
      241 trllsnekie taflnalvyl spnvecdlty hnvysrdpny lnlfiivmen rnlhspeyle
      301 malplfckam sklplaaqgk lirlwskyna dqirrmmetf qqlitykvis nefnsrnlvn
      361 dddaivaask clkmvyyanv vggevdtnhn eeddeepipe sseltlqell geerrnkkgp
      421 rvdpletelg vktldcrkpl ipfeefinep lnevlemdkd ytffkveten kfsfmtcpfi
      481 lnavtknlgl yydnrirmys erritvlysl vqgqqlnpyl rlkvrrdhii ddalvrlemi
      541 amenpadlkk qlyvefegeq gvdeggvske ffqlvveeif npdigmftyd estklfwfnp
      601 ssfetegqft ligivlglai ynncildvhf pmvvyrklmg kkgtfrdlgd shpvlyqslk
      661 dlleyegnve ddmmitfqis qtdlfgnpmm ydlkengdki pitnenrkef vnlysdyiln
      721 ksvekqfkaf rrgfhmvtne splkylfrpe eiellicgsr nldfqaleet teydggytrd
      781 svlirefwei vhsftdeqkr lflqfttgtd rapvgglgkl kmiiakngpd terlptshtc
      841 fnvlllpeys skeklkerll kaityakgfg ml
//
LOCUS       XP_016878039             872 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin-protein ligase E3A isoform X2 [Homo sapiens].
ACCESSION   XP_016878039
VERSION     XP_016878039.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022550.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..872
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..872
                     /product="ubiquitin-protein ligase E3A isoform X2"
                     /calculated_mol_wt=99971
     Region          26..80
                     /region_name="AZUL"
                     /note="Amino-terminal Zinc-binding domain of ubiquitin
                     ligase E3A; pfam16558"
                     /db_xref="CDD:465173"
     Region          520..870
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(526,559,570,627,805,834..835,838..842,862,869)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(655,658..659,661..662,665,673,675,679..680,682,688,
                     693,710,714)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..872
                     /gene="UBE3A"
                     /gene_synonym="ANCR; AS; E6-AP; EPVE6AP; HPVE6A; PIX1"
                     /coded_by="XM_017022550.3:1637..4255"
                     /db_xref="GeneID:7337"
                     /db_xref="HGNC:HGNC:12496"
                     /db_xref="MIM:601623"
ORIGIN      
        1 matackrsge pqsddieasr mkraaakhli eryyhqlteg cgneactnef cascptflrm
       61 dnnaaaikal elykinaklc dphpskkgas saylenskga pnnscseikm nkkgaridfk
      121 dvtylteekv yeilelcrer edysplirvi grvfssaeal vqsfrkvkqh tkeelkslqa
      181 kdedkdedek ekaacsaaam eedseasssr igdssqgdnn lqklgpddvs vdidairrvy
      241 trllsnekie taflnalvyl spnvecdlty hnvysrdpny lnlfiivmen rnlhspeyle
      301 malplfckam sklplaaqgk lirlwskyna dqirrmmetf qqlitykvis nefnsrnlvn
      361 dddaivaask clkmvyyanv vggevdtnhn eeddeepipe sseltlqell geerrnkkgp
      421 rvdpletelg vktldcrkpl ipfeefinep lnevlemdkd ytffkveten kfsfmtcpfi
      481 lnavtknlgl yydnrirmys erritvlysl vqgqqlnpyl rlkvrrdhii ddalvrlemi
      541 amenpadlkk qlyvefegeq gvdeggvske ffqlvveeif npdigmftyd estklfwfnp
      601 ssfetegqft ligivlglai ynncildvhf pmvvyrklmg kkgtfrdlgd shpvlyqslk
      661 dlleyegnve ddmmitfqis qtdlfgnpmm ydlkengdki pitnenrkef vnlysdyiln
      721 ksvekqfkaf rrgfhmvtne splkylfrpe eiellicgsr nldfqaleet teydggytrd
      781 svlirefwei vhsftdeqkr lflqfttgtd rapvgglgkl kmiiakngpd terlptshtc
      841 fnvlllpeys skeklkerll kaityakgfg ml
//
LOCUS       XP_047288972             852 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin-protein ligase E3A isoform X3 [Homo sapiens].
ACCESSION   XP_047288972
VERSION     XP_047288972.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433016.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..852
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..852
                     /product="ubiquitin-protein ligase E3A isoform X3"
                     /calculated_mol_wt=97837
     Region          6..60
                     /region_name="AZUL"
                     /note="Amino-terminal Zinc-binding domain of ubiquitin
                     ligase E3A; pfam16558"
                     /db_xref="CDD:465173"
     Region          500..850
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(506,539,550,607,785,814..815,818..822,842,849)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(635,638..639,641..642,645,653,655,659..660,662,668,
                     673,690,694)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..852
                     /gene="UBE3A"
                     /gene_synonym="ANCR; AS; E6-AP; EPVE6AP; HPVE6A; PIX1"
                     /coded_by="XM_047433016.1:716..3274"
                     /db_xref="GeneID:7337"
                     /db_xref="HGNC:HGNC:12496"
                     /db_xref="MIM:601623"
ORIGIN      
        1 mkraaakhli eryyhqlteg cgneactnef cascptflrm dnnaaaikal elykinaklc
       61 dphpskkgas saylenskga pnnscseikm nkkgaridfk dvtylteekv yeilelcrer
      121 edysplirvi grvfssaeal vqsfrkvkqh tkeelkslqa kdedkdedek ekaacsaaam
      181 eedseasssr igdssqgdnn lqklgpddvs vdidairrvy trllsnekie taflnalvyl
      241 spnvecdlty hnvysrdpny lnlfiivmen rnlhspeyle malplfckam sklplaaqgk
      301 lirlwskyna dqirrmmetf qqlitykvis nefnsrnlvn dddaivaask clkmvyyanv
      361 vggevdtnhn eeddeepipe sseltlqell geerrnkkgp rvdpletelg vktldcrkpl
      421 ipfeefinep lnevlemdkd ytffkveten kfsfmtcpfi lnavtknlgl yydnrirmys
      481 erritvlysl vqgqqlnpyl rlkvrrdhii ddalvrlemi amenpadlkk qlyvefegeq
      541 gvdeggvske ffqlvveeif npdigmftyd estklfwfnp ssfetegqft ligivlglai
      601 ynncildvhf pmvvyrklmg kkgtfrdlgd shpvlyqslk dlleyegnve ddmmitfqis
      661 qtdlfgnpmm ydlkengdki pitnenrkef vnlysdyiln ksvekqfkaf rrgfhmvtne
      721 splkylfrpe eiellicgsr nldfqaleet teydggytrd svlirefwei vhsftdeqkr
      781 lflqfttgtd rapvgglgkl kmiiakngpd terlptshtc fnvlllpeys skeklkerll
      841 kaityakgfg ml
//
LOCUS       XP_047288973             852 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin-protein ligase E3A isoform X3 [Homo sapiens].
ACCESSION   XP_047288973
VERSION     XP_047288973.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433017.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..852
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..852
                     /product="ubiquitin-protein ligase E3A isoform X3"
                     /calculated_mol_wt=97837
     Region          6..60
                     /region_name="AZUL"
                     /note="Amino-terminal Zinc-binding domain of ubiquitin
                     ligase E3A; pfam16558"
                     /db_xref="CDD:465173"
     Region          500..850
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(506,539,550,607,785,814..815,818..822,842,849)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(635,638..639,641..642,645,653,655,659..660,662,668,
                     673,690,694)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..852
                     /gene="UBE3A"
                     /gene_synonym="ANCR; AS; E6-AP; EPVE6AP; HPVE6A; PIX1"
                     /coded_by="XM_047433017.1:526..3084"
                     /db_xref="GeneID:7337"
                     /db_xref="HGNC:HGNC:12496"
                     /db_xref="MIM:601623"
ORIGIN      
        1 mkraaakhli eryyhqlteg cgneactnef cascptflrm dnnaaaikal elykinaklc
       61 dphpskkgas saylenskga pnnscseikm nkkgaridfk dvtylteekv yeilelcrer
      121 edysplirvi grvfssaeal vqsfrkvkqh tkeelkslqa kdedkdedek ekaacsaaam
      181 eedseasssr igdssqgdnn lqklgpddvs vdidairrvy trllsnekie taflnalvyl
      241 spnvecdlty hnvysrdpny lnlfiivmen rnlhspeyle malplfckam sklplaaqgk
      301 lirlwskyna dqirrmmetf qqlitykvis nefnsrnlvn dddaivaask clkmvyyanv
      361 vggevdtnhn eeddeepipe sseltlqell geerrnkkgp rvdpletelg vktldcrkpl
      421 ipfeefinep lnevlemdkd ytffkveten kfsfmtcpfi lnavtknlgl yydnrirmys
      481 erritvlysl vqgqqlnpyl rlkvrrdhii ddalvrlemi amenpadlkk qlyvefegeq
      541 gvdeggvske ffqlvveeif npdigmftyd estklfwfnp ssfetegqft ligivlglai
      601 ynncildvhf pmvvyrklmg kkgtfrdlgd shpvlyqslk dlleyegnve ddmmitfqis
      661 qtdlfgnpmm ydlkengdki pitnenrkef vnlysdyiln ksvekqfkaf rrgfhmvtne
      721 splkylfrpe eiellicgsr nldfqaleet teydggytrd svlirefwei vhsftdeqkr
      781 lflqfttgtd rapvgglgkl kmiiakngpd terlptshtc fnvlllpeys skeklkerll
      841 kaityakgfg ml
//
LOCUS       XP_047288974             852 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin-protein ligase E3A isoform X3 [Homo sapiens].
ACCESSION   XP_047288974
VERSION     XP_047288974.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433018.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..852
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..852
                     /product="ubiquitin-protein ligase E3A isoform X3"
                     /calculated_mol_wt=97837
     Region          6..60
                     /region_name="AZUL"
                     /note="Amino-terminal Zinc-binding domain of ubiquitin
                     ligase E3A; pfam16558"
                     /db_xref="CDD:465173"
     Region          500..850
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(506,539,550,607,785,814..815,818..822,842,849)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(635,638..639,641..642,645,653,655,659..660,662,668,
                     673,690,694)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..852
                     /gene="UBE3A"
                     /gene_synonym="ANCR; AS; E6-AP; EPVE6AP; HPVE6A; PIX1"
                     /coded_by="XM_047433018.1:335..2893"
                     /db_xref="GeneID:7337"
                     /db_xref="HGNC:HGNC:12496"
                     /db_xref="MIM:601623"
ORIGIN      
        1 mkraaakhli eryyhqlteg cgneactnef cascptflrm dnnaaaikal elykinaklc
       61 dphpskkgas saylenskga pnnscseikm nkkgaridfk dvtylteekv yeilelcrer
      121 edysplirvi grvfssaeal vqsfrkvkqh tkeelkslqa kdedkdedek ekaacsaaam
      181 eedseasssr igdssqgdnn lqklgpddvs vdidairrvy trllsnekie taflnalvyl
      241 spnvecdlty hnvysrdpny lnlfiivmen rnlhspeyle malplfckam sklplaaqgk
      301 lirlwskyna dqirrmmetf qqlitykvis nefnsrnlvn dddaivaask clkmvyyanv
      361 vggevdtnhn eeddeepipe sseltlqell geerrnkkgp rvdpletelg vktldcrkpl
      421 ipfeefinep lnevlemdkd ytffkveten kfsfmtcpfi lnavtknlgl yydnrirmys
      481 erritvlysl vqgqqlnpyl rlkvrrdhii ddalvrlemi amenpadlkk qlyvefegeq
      541 gvdeggvske ffqlvveeif npdigmftyd estklfwfnp ssfetegqft ligivlglai
      601 ynncildvhf pmvvyrklmg kkgtfrdlgd shpvlyqslk dlleyegnve ddmmitfqis
      661 qtdlfgnpmm ydlkengdki pitnenrkef vnlysdyiln ksvekqfkaf rrgfhmvtne
      721 splkylfrpe eiellicgsr nldfqaleet teydggytrd svlirefwei vhsftdeqkr
      781 lflqfttgtd rapvgglgkl kmiiakngpd terlptshtc fnvlllpeys skeklkerll
      841 kaityakgfg ml
//
LOCUS       XP_047288975             852 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin-protein ligase E3A isoform X3 [Homo sapiens].
ACCESSION   XP_047288975
VERSION     XP_047288975.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433019.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..852
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..852
                     /product="ubiquitin-protein ligase E3A isoform X3"
                     /calculated_mol_wt=97837
     Region          6..60
                     /region_name="AZUL"
                     /note="Amino-terminal Zinc-binding domain of ubiquitin
                     ligase E3A; pfam16558"
                     /db_xref="CDD:465173"
     Region          500..850
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(506,539,550,607,785,814..815,818..822,842,849)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(635,638..639,641..642,645,653,655,659..660,662,668,
                     673,690,694)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..852
                     /gene="UBE3A"
                     /gene_synonym="ANCR; AS; E6-AP; EPVE6AP; HPVE6A; PIX1"
                     /coded_by="XM_047433019.1:141..2699"
                     /db_xref="GeneID:7337"
                     /db_xref="HGNC:HGNC:12496"
                     /db_xref="MIM:601623"
ORIGIN      
        1 mkraaakhli eryyhqlteg cgneactnef cascptflrm dnnaaaikal elykinaklc
       61 dphpskkgas saylenskga pnnscseikm nkkgaridfk dvtylteekv yeilelcrer
      121 edysplirvi grvfssaeal vqsfrkvkqh tkeelkslqa kdedkdedek ekaacsaaam
      181 eedseasssr igdssqgdnn lqklgpddvs vdidairrvy trllsnekie taflnalvyl
      241 spnvecdlty hnvysrdpny lnlfiivmen rnlhspeyle malplfckam sklplaaqgk
      301 lirlwskyna dqirrmmetf qqlitykvis nefnsrnlvn dddaivaask clkmvyyanv
      361 vggevdtnhn eeddeepipe sseltlqell geerrnkkgp rvdpletelg vktldcrkpl
      421 ipfeefinep lnevlemdkd ytffkveten kfsfmtcpfi lnavtknlgl yydnrirmys
      481 erritvlysl vqgqqlnpyl rlkvrrdhii ddalvrlemi amenpadlkk qlyvefegeq
      541 gvdeggvske ffqlvveeif npdigmftyd estklfwfnp ssfetegqft ligivlglai
      601 ynncildvhf pmvvyrklmg kkgtfrdlgd shpvlyqslk dlleyegnve ddmmitfqis
      661 qtdlfgnpmm ydlkengdki pitnenrkef vnlysdyiln ksvekqfkaf rrgfhmvtne
      721 splkylfrpe eiellicgsr nldfqaleet teydggytrd svlirefwei vhsftdeqkr
      781 lflqfttgtd rapvgglgkl kmiiakngpd terlptshtc fnvlllpeys skeklkerll
      841 kaityakgfg ml
//
LOCUS       XP_047288976             823 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin-protein ligase E3A isoform X4 [Homo sapiens].
ACCESSION   XP_047288976
VERSION     XP_047288976.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433020.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..823
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..823
                     /product="ubiquitin-protein ligase E3A isoform X4"
                     /calculated_mol_wt=94318
     Region          29..83
                     /region_name="AZUL"
                     /note="Amino-terminal Zinc-binding domain of ubiquitin
                     ligase E3A; pfam16558"
                     /db_xref="CDD:465173"
     Region          523..821
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(529,562,573,630,756,785..786,789..793,813,820)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(658,661..662,664..665,668,676,678,682..683,685,691,
                     696)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..823
                     /gene="UBE3A"
                     /gene_synonym="ANCR; AS; E6-AP; EPVE6AP; HPVE6A; PIX1"
                     /coded_by="XM_047433020.1:451..2922"
                     /db_xref="GeneID:7337"
                     /db_xref="HGNC:HGNC:12496"
                     /db_xref="MIM:601623"
ORIGIN      
        1 meklhqcywk sgepqsddie asrmkraaak hlieryyhql tegcgneact nefcascptf
       61 lrmdnnaaai kalelykina klcdphpskk gassaylens kgapnnscse ikmnkkgari
      121 dfkdvtylte ekvyeilelc reredyspli rvigrvfssa ealvqsfrkv kqhtkeelks
      181 lqakdedkde dekekaacsa aameedseas ssrigdssqg dnnlqklgpd dvsvdidair
      241 rvytrllsne kietaflnal vylspnvecd ltyhnvysrd pnylnlfiiv menrnlhspe
      301 ylemalplfc kamsklplaa qgklirlwsk ynadqirrmm etfqqlityk visnefnsrn
      361 lvndddaiva askclkmvyy anvvggevdt nhneeddeep ipesseltlq ellgeerrnk
      421 kgprvdplet elgvktldcr kplipfeefi neplnevlem dkdytffkve tenkfsfmtc
      481 pfilnavtkn lglyydnrir myserritvl yslvqgqqln pylrlkvrrd hiiddalvrl
      541 emiamenpad lkkqlyvefe geqgvdeggv skeffqlvve eifnpdigmf tydestklfw
      601 fnpssfeteg qftligivlg laiynncild vhfpmvvyrk lmgkkgtfrd lgdshpvlyq
      661 slkdlleyeg nveddmmitf qisqtdlfgn pmmydlkeng dkipitnenr knldfqalee
      721 tteydggytr dsvlirefwe ivhsftdeqk rlflqfttgt drapvgglgk lkmiiakngp
      781 dterlptsht cfnvlllpey sskeklkerl lkaityakgf gml
//
LOCUS       XP_047288977             820 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin-protein ligase E3A isoform X5 [Homo sapiens].
ACCESSION   XP_047288977
VERSION     XP_047288977.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433021.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..820
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..820
                     /product="ubiquitin-protein ligase E3A isoform X5"
                     /calculated_mol_wt=93732
     Region          26..80
                     /region_name="AZUL"
                     /note="Amino-terminal Zinc-binding domain of ubiquitin
                     ligase E3A; pfam16558"
                     /db_xref="CDD:465173"
     Region          520..818
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(526,559,570,627,753,782..783,786..790,810,817)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(655,658..659,661..662,665,673,675,679..680,682,688,
                     693)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..820
                     /gene="UBE3A"
                     /gene_synonym="ANCR; AS; E6-AP; EPVE6AP; HPVE6A; PIX1"
                     /coded_by="XM_047433021.1:201..2663"
                     /db_xref="GeneID:7337"
                     /db_xref="HGNC:HGNC:12496"
                     /db_xref="MIM:601623"
ORIGIN      
        1 matackrsge pqsddieasr mkraaakhli eryyhqlteg cgneactnef cascptflrm
       61 dnnaaaikal elykinaklc dphpskkgas saylenskga pnnscseikm nkkgaridfk
      121 dvtylteekv yeilelcrer edysplirvi grvfssaeal vqsfrkvkqh tkeelkslqa
      181 kdedkdedek ekaacsaaam eedseasssr igdssqgdnn lqklgpddvs vdidairrvy
      241 trllsnekie taflnalvyl spnvecdlty hnvysrdpny lnlfiivmen rnlhspeyle
      301 malplfckam sklplaaqgk lirlwskyna dqirrmmetf qqlitykvis nefnsrnlvn
      361 dddaivaask clkmvyyanv vggevdtnhn eeddeepipe sseltlqell geerrnkkgp
      421 rvdpletelg vktldcrkpl ipfeefinep lnevlemdkd ytffkveten kfsfmtcpfi
      481 lnavtknlgl yydnrirmys erritvlysl vqgqqlnpyl rlkvrrdhii ddalvrlemi
      541 amenpadlkk qlyvefegeq gvdeggvske ffqlvveeif npdigmftyd estklfwfnp
      601 ssfetegqft ligivlglai ynncildvhf pmvvyrklmg kkgtfrdlgd shpvlyqslk
      661 dlleyegnve ddmmitfqis qtdlfgnpmm ydlkengdki pitnenrknl dfqaleette
      721 ydggytrdsv lirefweivh sftdeqkrlf lqfttgtdra pvgglgklkm iiakngpdte
      781 rlptshtcfn vlllpeyssk eklkerllka ityakgfgml
//
LOCUS       XP_016878049             429 aa            linear   PRI 05-AUG-2025
DEFINITION  putative proton-coupled zinc antiporter SLC30A4 isoform X1 [Homo
            sapiens].
ACCESSION   XP_016878049
VERSION     XP_016878049.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022560.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..429
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..429
                     /product="putative proton-coupled zinc antiporter SLC30A4
                     isoform X1"
                     /calculated_mol_wt=47352
     Region          123..413
                     /region_name="CDF"
                     /note="cation diffusion facilitator family transporter;
                     TIGR01297"
                     /db_xref="CDD:273544"
     CDS             1..429
                     /gene="SLC30A4"
                     /gene_synonym="znT-4; ZNT4"
                     /coded_by="XM_017022560.3:402..1691"
                     /db_xref="GeneID:7782"
                     /db_xref="HGNC:HGNC:11015"
                     /db_xref="MIM:602095"
ORIGIN      
        1 magsgawkrl ksmlrkddap lflndtsafd fsdeagdegl srfnklrvvv addgseaper
       61 pvngahptlq adddslldqd lpltnsqlsl kvdscdncsk qreilkqrkv karltiaavl
      121 yllfmigelv ggyianslai mtdalhmltd lsaiiltlla lwlssksptk rftfgfhrle
      181 vlsamisvll vyilmgflly eavqrtihmn yeingdimli taavgvavnv imgfllnqsg
      241 hrhshshslp snsptrgsgc ernhgqdsla vraafvhalg dlvqsvgvli aayiirfkpe
      301 ykiadpicty vfsllvaftt friiwdtvvi ilegvpshln vdyikealmk iedvysvedl
      361 niwsltsgks taivhiqlip gssskweevq skanhlllnt fgmyrctiql qsyrqevdrt
      421 cancqsssp
//
LOCUS       XP_016878050             199 aa            linear   PRI 05-AUG-2025
DEFINITION  putative proton-coupled zinc antiporter SLC30A4 isoform X2 [Homo
            sapiens].
ACCESSION   XP_016878050
VERSION     XP_016878050.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022561.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..199
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..199
                     /product="putative proton-coupled zinc antiporter SLC30A4
                     isoform X2"
                     /calculated_mol_wt=21897
     Region          113..>180
                     /region_name="CzcD"
                     /note="Co/Zn/Cd efflux system component [Inorganic ion
                     transport and metabolism]; COG1230"
                     /db_xref="CDD:440843"
     CDS             1..199
                     /gene="SLC30A4"
                     /gene_synonym="znT-4; ZNT4"
                     /coded_by="XM_017022561.2:264..863"
                     /db_xref="GeneID:7782"
                     /db_xref="HGNC:HGNC:11015"
                     /db_xref="MIM:602095"
ORIGIN      
        1 magsgawkrl ksmlrkddap lflndtsafd fsdeagdegl srfnklrvvv addgseaper
       61 pvngahptlq adddslldqd lpltnsqlsl kvdscdncsk qreilkqrkv karltiaavl
      121 yllfmigelv ggyianslai mtdalhmltd lsaiiltlla lwlssksptk rftfgfhrlg
      181 ykpfgilmka vkhslrnmq
//
LOCUS       XP_047288979             187 aa            linear   PRI 05-AUG-2025
DEFINITION  putative proton-coupled zinc antiporter SLC30A4 isoform X3 [Homo
            sapiens].
ACCESSION   XP_047288979
VERSION     XP_047288979.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433023.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..187
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..187
                     /product="putative proton-coupled zinc antiporter SLC30A4
                     isoform X3"
                     /calculated_mol_wt=20472
     Region          113..>180
                     /region_name="CzcD"
                     /note="Co/Zn/Cd efflux system component [Inorganic ion
                     transport and metabolism]; COG1230"
                     /db_xref="CDD:440843"
     CDS             1..187
                     /gene="SLC30A4"
                     /gene_synonym="znT-4; ZNT4"
                     /coded_by="XM_047433023.1:402..965"
                     /db_xref="GeneID:7782"
                     /db_xref="HGNC:HGNC:11015"
                     /db_xref="MIM:602095"
ORIGIN      
        1 magsgawkrl ksmlrkddap lflndtsafd fsdeagdegl srfnklrvvv addgseaper
       61 pvngahptlq adddslldqd lpltnsqlsl kvdscdncsk qreilkqrkv karltiaavl
      121 yllfmigelv ggyianslai mtdalhmltd lsaiiltlla lwlssksptk rftfgfhrlg
      181 wntmtps
//
LOCUS       XP_024305816             584 aa            linear   PRI 05-AUG-2025
DEFINITION  elongation factor-like GTPase 1 isoform X1 [Homo sapiens].
ACCESSION   XP_024305816
VERSION     XP_024305816.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024450048.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..584
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..584
                     /product="elongation factor-like GTPase 1 isoform X1"
                     /calculated_mol_wt=65346
     Region          <29..567
                     /region_name="PRK13351"
                     /note="elongation factor G-like protein; cl46912"
                     /db_xref="CDD:481252"
     CDS             1..584
                     /gene="EFL1"
                     /gene_synonym="EFTUD1; FAM42A; HsT19294; RIA1; SDS2"
                     /coded_by="XM_024450048.2:3976..5730"
                     /db_xref="GeneID:79631"
                     /db_xref="HGNC:HGNC:25789"
                     /db_xref="MIM:617538"
ORIGIN      
        1 mvplgfsapp dglpqvphma ycalenlyll mgreleylee vppgnvlgig glqdfvlksa
       61 tlcslpscpp fiplnfeatp ivrvavepkh psempqlvkg mkllnqadpc vqiliqetge
      121 hvlvtagevh lqrclddlke rfakihisvs epiipfreti tkppkvdmvn eeigkqqkva
      181 vihqmkedqs kipegiqvds dglitittpn klatlsvram plpeevtqil eensdlirsm
      241 eqltsslneg enthmihqkt qekiwefkgk leqhltgrrw rnivdqiwsf gprkcgpnil
      301 vnksedfqns vwtgpadkas keasryrdlg nsivsgfqla tlsgpmceep lmgvcfvlek
      361 wdlskfeeqg asdlakegqe enetcsggne nqelqdgcse afekrtsqkg espltdcygp
      421 fsgqliatmk eacryalqvk pqrlmaamyt cdimatgdvl grvyavlskr egrvlqeemk
      481 egtdmfiika vlpvaesfgf adeirkrtsg laspqlvfsh weiipsdpfw vptteeeylh
      541 fgekadsenq arkymnavrk rkglyveeki vehaekqrtl sknk
//
LOCUS       XP_016878058             982 aa            linear   PRI 05-AUG-2025
DEFINITION  little elongation complex subunit 2 isoform X1 [Homo sapiens].
ACCESSION   XP_016878058
VERSION     XP_016878058.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022569.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..982
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..982
                     /product="little elongation complex subunit 2 isoform X1"
                     /calculated_mol_wt=109881
     Region          720..930
                     /region_name="NARG2_C"
                     /note="NMDA receptor-regulated gene protein 2 C-terminus;
                     pfam10505"
                     /db_xref="CDD:463121"
     CDS             1..982
                     /gene="ICE2"
                     /gene_synonym="BRCC1; NARG2"
                     /coded_by="XM_017022569.3:326..3274"
                     /db_xref="GeneID:79664"
                     /db_xref="HGNC:HGNC:29885"
                     /db_xref="MIM:610835"
ORIGIN      
        1 msskmvisep glnwdispkn glktffsren ykdhsmapsl kelrvlsnrr igenlnasas
       61 svenepavss atqakekvkt tigmvllpkp rvpyprfsrf sqreqrsyvd llvkyakipa
      121 nskavginkn dylqyldmkk hvneevtefl kflqnsakkc aqdynmlsdd arlftekilr
      181 acieqvkkys efytlhevts lmgffpfrve mglklektll algsvkyvkt vfpsmpiklq
      241 lskddiatie tseqtaeamh ydiskdpnae klvsryhpqi altsqslftl lnnhgptyke
      301 qweipvciqv ipvagskpvk viyinsplpq kkmtmrernq ifhevplkfm mskntsvpvs
      361 avfmdkpeef isemdmscev necrkiesle nlyldfdddv teletfgvtt tkvskspspa
      421 ststvpnmtd aptapkagtt tvapsapdis ansrslsqil meqlqkekql vtgmdggpee
      481 cknkddqgfe scekvsnsdk pliqdsdlkt sdalqlensq eietsnkndm tidilhadge
      541 rpnvlenldn skektvgsea aktedtvlcs sdtdeeclii dtecknnsdg ktavvgsnls
      601 srpaspnsss gqasvgnqtn tacspeescv lkkpikrvyk kfdpvgeilk mqdellkpis
      661 rkvpelplmn lenskqpsvs eqlsgpsdss swpksgwpsa fqkpkgrlpy elqdyvedts
      721 eylapqegnf vyklfslqdl lllvrcsvqr ietrprskkr kkirrqfpvy vlpkveyqac
      781 ygvealtese lcrlwtesll hsnssfyvgh idaftsklfl leeitseelk eklsalkisn
      841 lfnilqhilk klsslqegsy llshaaedss lliykasdgk vtrtaynlyk thcglpgvps
      901 slsvpwvpld pslllpyhih hgripctfpp ksldtttqqk iggtrmptrs hrnpvsmetk
      961 ssclpaqqve tegvaphkrk it
//
LOCUS       XP_011520311             982 aa            linear   PRI 05-AUG-2025
DEFINITION  little elongation complex subunit 2 isoform X1 [Homo sapiens].
ACCESSION   XP_011520311
VERSION     XP_011520311.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522009.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..982
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..982
                     /product="little elongation complex subunit 2 isoform X1"
                     /calculated_mol_wt=109881
     Region          720..930
                     /region_name="NARG2_C"
                     /note="NMDA receptor-regulated gene protein 2 C-terminus;
                     pfam10505"
                     /db_xref="CDD:463121"
     CDS             1..982
                     /gene="ICE2"
                     /gene_synonym="BRCC1; NARG2"
                     /coded_by="XM_011522009.3:164..3112"
                     /db_xref="GeneID:79664"
                     /db_xref="HGNC:HGNC:29885"
                     /db_xref="MIM:610835"
ORIGIN      
        1 msskmvisep glnwdispkn glktffsren ykdhsmapsl kelrvlsnrr igenlnasas
       61 svenepavss atqakekvkt tigmvllpkp rvpyprfsrf sqreqrsyvd llvkyakipa
      121 nskavginkn dylqyldmkk hvneevtefl kflqnsakkc aqdynmlsdd arlftekilr
      181 acieqvkkys efytlhevts lmgffpfrve mglklektll algsvkyvkt vfpsmpiklq
      241 lskddiatie tseqtaeamh ydiskdpnae klvsryhpqi altsqslftl lnnhgptyke
      301 qweipvciqv ipvagskpvk viyinsplpq kkmtmrernq ifhevplkfm mskntsvpvs
      361 avfmdkpeef isemdmscev necrkiesle nlyldfdddv teletfgvtt tkvskspspa
      421 ststvpnmtd aptapkagtt tvapsapdis ansrslsqil meqlqkekql vtgmdggpee
      481 cknkddqgfe scekvsnsdk pliqdsdlkt sdalqlensq eietsnkndm tidilhadge
      541 rpnvlenldn skektvgsea aktedtvlcs sdtdeeclii dtecknnsdg ktavvgsnls
      601 srpaspnsss gqasvgnqtn tacspeescv lkkpikrvyk kfdpvgeilk mqdellkpis
      661 rkvpelplmn lenskqpsvs eqlsgpsdss swpksgwpsa fqkpkgrlpy elqdyvedts
      721 eylapqegnf vyklfslqdl lllvrcsvqr ietrprskkr kkirrqfpvy vlpkveyqac
      781 ygvealtese lcrlwtesll hsnssfyvgh idaftsklfl leeitseelk eklsalkisn
      841 lfnilqhilk klsslqegsy llshaaedss lliykasdgk vtrtaynlyk thcglpgvps
      901 slsvpwvpld pslllpyhih hgripctfpp ksldtttqqk iggtrmptrs hrnpvsmetk
      961 ssclpaqqve tegvaphkrk it
//
LOCUS       XP_047288983             889 aa            linear   PRI 05-AUG-2025
DEFINITION  little elongation complex subunit 2 isoform X2 [Homo sapiens].
ACCESSION   XP_047288983
VERSION     XP_047288983.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433027.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..889
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..889
                     /product="little elongation complex subunit 2 isoform X2"
                     /calculated_mol_wt=99857
     Region          720..>853
                     /region_name="eIF-3_zeta"
                     /note="Eukaryotic translation initiation factor 3 subunit
                     7 (eIF-3); cl46347"
                     /db_xref="CDD:480687"
     CDS             1..889
                     /gene="ICE2"
                     /gene_synonym="BRCC1; NARG2"
                     /coded_by="XM_047433027.1:326..2995"
                     /db_xref="GeneID:79664"
                     /db_xref="HGNC:HGNC:29885"
                     /db_xref="MIM:610835"
ORIGIN      
        1 msskmvisep glnwdispkn glktffsren ykdhsmapsl kelrvlsnrr igenlnasas
       61 svenepavss atqakekvkt tigmvllpkp rvpyprfsrf sqreqrsyvd llvkyakipa
      121 nskavginkn dylqyldmkk hvneevtefl kflqnsakkc aqdynmlsdd arlftekilr
      181 acieqvkkys efytlhevts lmgffpfrve mglklektll algsvkyvkt vfpsmpiklq
      241 lskddiatie tseqtaeamh ydiskdpnae klvsryhpqi altsqslftl lnnhgptyke
      301 qweipvciqv ipvagskpvk viyinsplpq kkmtmrernq ifhevplkfm mskntsvpvs
      361 avfmdkpeef isemdmscev necrkiesle nlyldfdddv teletfgvtt tkvskspspa
      421 ststvpnmtd aptapkagtt tvapsapdis ansrslsqil meqlqkekql vtgmdggpee
      481 cknkddqgfe scekvsnsdk pliqdsdlkt sdalqlensq eietsnkndm tidilhadge
      541 rpnvlenldn skektvgsea aktedtvlcs sdtdeeclii dtecknnsdg ktavvgsnls
      601 srpaspnsss gqasvgnqtn tacspeescv lkkpikrvyk kfdpvgeilk mqdellkpis
      661 rkvpelplmn lenskqpsvs eqlsgpsdss swpksgwpsa fqkpkgrlpy elqdyvedts
      721 eylapqegnf vyklfslqdl lllvrcsvqr ietrprskkr kkirrqfpvy vlpkveyqac
      781 ygvealtese lcrlwtesll hsnssfyvgh idaftsklfl leeitseelk eklsalkisn
      841 lfnilqhilk klsrachldl cvashcllsf cacrrvptcy lmqqkilhs
//
LOCUS       XP_047288984             889 aa            linear   PRI 05-AUG-2025
DEFINITION  little elongation complex subunit 2 isoform X2 [Homo sapiens].
ACCESSION   XP_047288984
VERSION     XP_047288984.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433028.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..889
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..889
                     /product="little elongation complex subunit 2 isoform X2"
                     /calculated_mol_wt=99857
     Region          720..>853
                     /region_name="eIF-3_zeta"
                     /note="Eukaryotic translation initiation factor 3 subunit
                     7 (eIF-3); cl46347"
                     /db_xref="CDD:480687"
     CDS             1..889
                     /gene="ICE2"
                     /gene_synonym="BRCC1; NARG2"
                     /coded_by="XM_047433028.1:164..2833"
                     /db_xref="GeneID:79664"
                     /db_xref="HGNC:HGNC:29885"
                     /db_xref="MIM:610835"
ORIGIN      
        1 msskmvisep glnwdispkn glktffsren ykdhsmapsl kelrvlsnrr igenlnasas
       61 svenepavss atqakekvkt tigmvllpkp rvpyprfsrf sqreqrsyvd llvkyakipa
      121 nskavginkn dylqyldmkk hvneevtefl kflqnsakkc aqdynmlsdd arlftekilr
      181 acieqvkkys efytlhevts lmgffpfrve mglklektll algsvkyvkt vfpsmpiklq
      241 lskddiatie tseqtaeamh ydiskdpnae klvsryhpqi altsqslftl lnnhgptyke
      301 qweipvciqv ipvagskpvk viyinsplpq kkmtmrernq ifhevplkfm mskntsvpvs
      361 avfmdkpeef isemdmscev necrkiesle nlyldfdddv teletfgvtt tkvskspspa
      421 ststvpnmtd aptapkagtt tvapsapdis ansrslsqil meqlqkekql vtgmdggpee
      481 cknkddqgfe scekvsnsdk pliqdsdlkt sdalqlensq eietsnkndm tidilhadge
      541 rpnvlenldn skektvgsea aktedtvlcs sdtdeeclii dtecknnsdg ktavvgsnls
      601 srpaspnsss gqasvgnqtn tacspeescv lkkpikrvyk kfdpvgeilk mqdellkpis
      661 rkvpelplmn lenskqpsvs eqlsgpsdss swpksgwpsa fqkpkgrlpy elqdyvedts
      721 eylapqegnf vyklfslqdl lllvrcsvqr ietrprskkr kkirrqfpvy vlpkveyqac
      781 ygvealtese lcrlwtesll hsnssfyvgh idaftsklfl leeitseelk eklsalkisn
      841 lfnilqhilk klsrachldl cvashcllsf cacrrvptcy lmqqkilhs
//
LOCUS       XP_047288985             889 aa            linear   PRI 05-AUG-2025
DEFINITION  little elongation complex subunit 2 isoform X2 [Homo sapiens].
ACCESSION   XP_047288985
VERSION     XP_047288985.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433029.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..889
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..889
                     /product="little elongation complex subunit 2 isoform X2"
                     /calculated_mol_wt=99857
     Region          720..>853
                     /region_name="eIF-3_zeta"
                     /note="Eukaryotic translation initiation factor 3 subunit
                     7 (eIF-3); cl46347"
                     /db_xref="CDD:480687"
     CDS             1..889
                     /gene="ICE2"
                     /gene_synonym="BRCC1; NARG2"
                     /coded_by="XM_047433029.1:233..2902"
                     /db_xref="GeneID:79664"
                     /db_xref="HGNC:HGNC:29885"
                     /db_xref="MIM:610835"
ORIGIN      
        1 msskmvisep glnwdispkn glktffsren ykdhsmapsl kelrvlsnrr igenlnasas
       61 svenepavss atqakekvkt tigmvllpkp rvpyprfsrf sqreqrsyvd llvkyakipa
      121 nskavginkn dylqyldmkk hvneevtefl kflqnsakkc aqdynmlsdd arlftekilr
      181 acieqvkkys efytlhevts lmgffpfrve mglklektll algsvkyvkt vfpsmpiklq
      241 lskddiatie tseqtaeamh ydiskdpnae klvsryhpqi altsqslftl lnnhgptyke
      301 qweipvciqv ipvagskpvk viyinsplpq kkmtmrernq ifhevplkfm mskntsvpvs
      361 avfmdkpeef isemdmscev necrkiesle nlyldfdddv teletfgvtt tkvskspspa
      421 ststvpnmtd aptapkagtt tvapsapdis ansrslsqil meqlqkekql vtgmdggpee
      481 cknkddqgfe scekvsnsdk pliqdsdlkt sdalqlensq eietsnkndm tidilhadge
      541 rpnvlenldn skektvgsea aktedtvlcs sdtdeeclii dtecknnsdg ktavvgsnls
      601 srpaspnsss gqasvgnqtn tacspeescv lkkpikrvyk kfdpvgeilk mqdellkpis
      661 rkvpelplmn lenskqpsvs eqlsgpsdss swpksgwpsa fqkpkgrlpy elqdyvedts
      721 eylapqegnf vyklfslqdl lllvrcsvqr ietrprskkr kkirrqfpvy vlpkveyqac
      781 ygvealtese lcrlwtesll hsnssfyvgh idaftsklfl leeitseelk eklsalkisn
      841 lfnilqhilk klsrachldl cvashcllsf cacrrvptcy lmqqkilhs
//
LOCUS       XP_047288986             845 aa            linear   PRI 05-AUG-2025
DEFINITION  little elongation complex subunit 2 isoform X3 [Homo sapiens].
ACCESSION   XP_047288986
VERSION     XP_047288986.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433030.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..845
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..845
                     /product="little elongation complex subunit 2 isoform X3"
                     /calculated_mol_wt=94419
     Region          583..793
                     /region_name="NARG2_C"
                     /note="NMDA receptor-regulated gene protein 2 C-terminus;
                     pfam10505"
                     /db_xref="CDD:463121"
     CDS             1..845
                     /gene="ICE2"
                     /gene_synonym="BRCC1; NARG2"
                     /coded_by="XM_047433030.1:212..2749"
                     /db_xref="GeneID:79664"
                     /db_xref="HGNC:HGNC:29885"
                     /db_xref="MIM:610835"
ORIGIN      
        1 mkkhvneevt eflkflqnsa kkcaqdynml sddarlftek ilracieqvk kysefytlhe
       61 vtslmgffpf rvemglklek tllalgsvky vktvfpsmpi klqlskddia tietseqtae
      121 amhydiskdp naeklvsryh pqialtsqsl ftllnnhgpt ykeqweipvc iqvipvagsk
      181 pvkviyinsp lpqkkmtmre rnqifhevpl kfmmskntsv pvsavfmdkp eefisemdms
      241 cevnecrkie slenlyldfd ddvteletfg vtttkvsksp spaststvpn mtdaptapka
      301 gtttvapsap disansrsls qilmeqlqke kqlvtgmdgg peecknkddq gfescekvsn
      361 sdkpliqdsd lktsdalqle nsqeietsnk ndmtidilha dgerpnvlen ldnskektvg
      421 seaaktedtv lcssdtdeec liidtecknn sdgktavvgs nlssrpaspn sssgqasvgn
      481 qtntacspee scvlkkpikr vykkfdpvge ilkmqdellk pisrkvpelp lmnlenskqp
      541 svseqlsgps dssswpksgw psafqkpkgr lpyelqdyve dtseylapqe gnfvyklfsl
      601 qdllllvrcs vqrietrprs kkrkkirrqf pvyvlpkvey qacygvealt eselcrlwte
      661 sllhsnssfy vghidaftsk lflleeitse elkeklsalk isnlfnilqh ilkklsslqe
      721 gsyllshaae dsslliykas dgkvtrtayn lykthcglpg vpsslsvpwv pldpslllpy
      781 hihhgripct fppksldttt qqkiggtrmp trshrnpvsm etkssclpaq qvetegvaph
      841 krkit
//
LOCUS       XP_047288987             834 aa            linear   PRI 05-AUG-2025
DEFINITION  little elongation complex subunit 2 isoform X4 [Homo sapiens].
ACCESSION   XP_047288987
VERSION     XP_047288987.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433031.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..834
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..834
                     /product="little elongation complex subunit 2 isoform X4"
                     /calculated_mol_wt=93465
     Region          720..>832
                     /region_name="eIF-3_zeta"
                     /note="Eukaryotic translation initiation factor 3 subunit
                     7 (eIF-3); cl46347"
                     /db_xref="CDD:480687"
     CDS             1..834
                     /gene="ICE2"
                     /gene_synonym="BRCC1; NARG2"
                     /coded_by="XM_047433031.1:233..2737"
                     /db_xref="GeneID:79664"
                     /db_xref="HGNC:HGNC:29885"
                     /db_xref="MIM:610835"
ORIGIN      
        1 msskmvisep glnwdispkn glktffsren ykdhsmapsl kelrvlsnrr igenlnasas
       61 svenepavss atqakekvkt tigmvllpkp rvpyprfsrf sqreqrsyvd llvkyakipa
      121 nskavginkn dylqyldmkk hvneevtefl kflqnsakkc aqdynmlsdd arlftekilr
      181 acieqvkkys efytlhevts lmgffpfrve mglklektll algsvkyvkt vfpsmpiklq
      241 lskddiatie tseqtaeamh ydiskdpnae klvsryhpqi altsqslftl lnnhgptyke
      301 qweipvciqv ipvagskpvk viyinsplpq kkmtmrernq ifhevplkfm mskntsvpvs
      361 avfmdkpeef isemdmscev necrkiesle nlyldfdddv teletfgvtt tkvskspspa
      421 ststvpnmtd aptapkagtt tvapsapdis ansrslsqil meqlqkekql vtgmdggpee
      481 cknkddqgfe scekvsnsdk pliqdsdlkt sdalqlensq eietsnkndm tidilhadge
      541 rpnvlenldn skektvgsea aktedtvlcs sdtdeeclii dtecknnsdg ktavvgsnls
      601 srpaspnsss gqasvgnqtn tacspeescv lkkpikrvyk kfdpvgeilk mqdellkpis
      661 rkvpelplmn lenskqpsvs eqlsgpsdss swpksgwpsa fqkpkgrlpy elqdyvedts
      721 eylapqegnf vyklfslqdl lllvrcsvqr ietrprskkr kkirrqfpvy vlpkveyqac
      781 ygvealtese lcrlwtesll hsnssfyvgr csrkslevll kveiagptle clih
//
LOCUS       XP_047288988             834 aa            linear   PRI 05-AUG-2025
DEFINITION  little elongation complex subunit 2 isoform X4 [Homo sapiens].
ACCESSION   XP_047288988
VERSION     XP_047288988.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433032.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..834
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..834
                     /product="little elongation complex subunit 2 isoform X4"
                     /calculated_mol_wt=93465
     Region          720..>832
                     /region_name="eIF-3_zeta"
                     /note="Eukaryotic translation initiation factor 3 subunit
                     7 (eIF-3); cl46347"
                     /db_xref="CDD:480687"
     CDS             1..834
                     /gene="ICE2"
                     /gene_synonym="BRCC1; NARG2"
                     /coded_by="XM_047433032.1:326..2830"
                     /db_xref="GeneID:79664"
                     /db_xref="HGNC:HGNC:29885"
                     /db_xref="MIM:610835"
ORIGIN      
        1 msskmvisep glnwdispkn glktffsren ykdhsmapsl kelrvlsnrr igenlnasas
       61 svenepavss atqakekvkt tigmvllpkp rvpyprfsrf sqreqrsyvd llvkyakipa
      121 nskavginkn dylqyldmkk hvneevtefl kflqnsakkc aqdynmlsdd arlftekilr
      181 acieqvkkys efytlhevts lmgffpfrve mglklektll algsvkyvkt vfpsmpiklq
      241 lskddiatie tseqtaeamh ydiskdpnae klvsryhpqi altsqslftl lnnhgptyke
      301 qweipvciqv ipvagskpvk viyinsplpq kkmtmrernq ifhevplkfm mskntsvpvs
      361 avfmdkpeef isemdmscev necrkiesle nlyldfdddv teletfgvtt tkvskspspa
      421 ststvpnmtd aptapkagtt tvapsapdis ansrslsqil meqlqkekql vtgmdggpee
      481 cknkddqgfe scekvsnsdk pliqdsdlkt sdalqlensq eietsnkndm tidilhadge
      541 rpnvlenldn skektvgsea aktedtvlcs sdtdeeclii dtecknnsdg ktavvgsnls
      601 srpaspnsss gqasvgnqtn tacspeescv lkkpikrvyk kfdpvgeilk mqdellkpis
      661 rkvpelplmn lenskqpsvs eqlsgpsdss swpksgwpsa fqkpkgrlpy elqdyvedts
      721 eylapqegnf vyklfslqdl lllvrcsvqr ietrprskkr kkirrqfpvy vlpkveyqac
      781 ygvealtese lcrlwtesll hsnssfyvgr csrkslevll kveiagptle clih
//
LOCUS       XP_047288989             772 aa            linear   PRI 05-AUG-2025
DEFINITION  little elongation complex subunit 2 isoform X5 [Homo sapiens].
ACCESSION   XP_047288989
VERSION     XP_047288989.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433033.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..772
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..772
                     /product="little elongation complex subunit 2 isoform X5"
                     /calculated_mol_wt=86407
     CDS             1..772
                     /gene="ICE2"
                     /gene_synonym="BRCC1; NARG2"
                     /coded_by="XM_047433033.1:233..2551"
                     /db_xref="GeneID:79664"
                     /db_xref="HGNC:HGNC:29885"
                     /db_xref="MIM:610835"
ORIGIN      
        1 msskmvisep glnwdispkn glktffsren ykdhsmapsl kelrvlsnrr igenlnasas
       61 svenepavss atqakekvkt tigmvllpkp rvpyprfsrf sqreqrsyvd llvkyakipa
      121 nskavginkn dylqyldmkk hvneevtefl kflqnsakkc aqdynmlsdd arlftekilr
      181 acieqvkkys efytlhevts lmgffpfrve mglklektll algsvkyvkt vfpsmpiklq
      241 lskddiatie tseqtaeamh ydiskdpnae klvsryhpqi altsqslftl lnnhgptyke
      301 qweipvciqv ipvagskpvk viyinsplpq kkmtmrernq ifhevplkfm mskntsvpvs
      361 avfmdkpeef isemdmscev necrkiesle nlyldfdddv teletfgvtt tkvskspspa
      421 ststvpnmtd aptapkagtt tvapsapdis ansrslsqil meqlqkekql vtgmdggpee
      481 cknkddqgfe scekvsnsdk pliqdsdlkt sdalqlensq eietsnkndm tidilhadge
      541 rpnvlenldn skektvgsea aktedtvlcs sdtdeeclii dtecknnsdg ktavvgsnls
      601 srpaspnsss gqasvgnqtn tacspeescv lkkpikrvyk kfdpvgeilk mqdellkpis
      661 rkvpelplmn lenskqpsvs eqlsgpsdss swpksgwpsa fqkpkgrlpy elqdyvedts
      721 eylapqegnf vyklfslqdl lllvrcsvqr ietrprskkr kkirrltalr nc
//
LOCUS       XP_024305820             206 aa            linear   PRI 05-AUG-2025
DEFINITION  alpha- and gamma-adaptin-binding protein p34 isoform X1 [Homo
            sapiens].
ACCESSION   XP_024305820
VERSION     XP_024305820.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024450052.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..206
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..206
                     /product="alpha- and gamma-adaptin-binding protein p34
                     isoform X1"
                     /calculated_mol_wt=22896
     Region          155..>181
                     /region_name="Adaptin_binding"
                     /note="Alpha and gamma adaptin binding protein p34;
                     pfam10199"
                     /db_xref="CDD:462994"
     CDS             1..206
                     /gene="AAGAB"
                     /gene_synonym="KPPP1; p34; PPKP1; PPKP1A"
                     /coded_by="XM_024450052.2:31..651"
                     /db_xref="GeneID:79719"
                     /db_xref="HGNC:HGNC:25662"
                     /db_xref="MIM:614888"
ORIGIN      
        1 maagvpcalv tscssvfsgd qlvqhilgte dlivevtsnd avrfypwtid nkyysadinl
       61 cvvpnkflvt aeiaesvqaf vvyfdstqks gldsvsswlp lakawlpevm ilvcdrvsed
      121 ginrqkaqew cikhgfelve lspeelpeed ddfpestgvk rivqalnanv wsnvvmkngs
      181 srfglmkgen gkwrrkhdie nnssmf
//
LOCUS       XP_024305821             194 aa            linear   PRI 05-AUG-2025
DEFINITION  alpha- and gamma-adaptin-binding protein p34 isoform X2 [Homo
            sapiens].
ACCESSION   XP_024305821
VERSION     XP_024305821.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024450053.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..194
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..194
                     /product="alpha- and gamma-adaptin-binding protein p34
                     isoform X2"
                     /calculated_mol_wt=21534
     Region          155..>180
                     /region_name="Adaptin_binding"
                     /note="Alpha and gamma adaptin binding protein p34;
                     pfam10199"
                     /db_xref="CDD:462994"
     CDS             1..194
                     /gene="AAGAB"
                     /gene_synonym="KPPP1; p34; PPKP1; PPKP1A"
                     /coded_by="XM_024450053.2:31..615"
                     /db_xref="GeneID:79719"
                     /db_xref="HGNC:HGNC:25662"
                     /db_xref="MIM:614888"
ORIGIN      
        1 maagvpcalv tscssvfsgd qlvqhilgte dlivevtsnd avrfypwtid nkyysadinl
       61 cvvpnkflvt aeiaesvqaf vvyfdstqks gldsvsswlp lakawlpevm ilvcdrvsed
      121 ginrqkaqew cikhgfelve lspeelpeed ddfpestgvk rivqalnanv wsnvvmknvs
      181 wtlifkgqif nlki
//
LOCUS       XP_016878060             304 aa            linear   PRI 05-AUG-2025
DEFINITION  KATNB1-like protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_016878060
VERSION     XP_016878060.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022571.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..304
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..304
                     /product="KATNB1-like protein 1 isoform X1"
                     /calculated_mol_wt=34636
     Region          149..300
                     /region_name="Katanin_con80"
                     /note="con80 domain of Katanin; pfam13925"
                     /db_xref="CDD:464044"
     CDS             1..304
                     /gene="KATNBL1"
                     /gene_synonym="C15orf29"
                     /coded_by="XM_017022571.3:340..1254"
                     /db_xref="GeneID:79768"
                     /db_xref="HGNC:HGNC:26199"
                     /db_xref="MIM:616235"
ORIGIN      
        1 masethnvkk rnfcnkiedh fidlprkkis nftnknmkev kkspkqlaay inrtvgqtvk
       61 spdklrkviy rrkkvhhpfp npcyrkkqsp gsggcdmank enelacaghl peklhhdsrt
      121 ylvnssdsgs sqtespssky sgffsevsqd hetmaqvlfs rnmrlnvalt fwrkrsisel
      181 vayllriedl gvvvdclpvl tnclqeekqy islgccvdll plvksllksk feeyvivgln
      241 wlqavikrww selsskteii ndgniqilkq qlsglweqen hltlvpgytg niakdvdayl
      301 lqlh
//
LOCUS       XP_047288992             304 aa            linear   PRI 05-AUG-2025
DEFINITION  KATNB1-like protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047288992
VERSION     XP_047288992.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433036.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..304
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..304
                     /product="KATNB1-like protein 1 isoform X1"
                     /calculated_mol_wt=34636
     Region          149..300
                     /region_name="Katanin_con80"
                     /note="con80 domain of Katanin; pfam13925"
                     /db_xref="CDD:464044"
     CDS             1..304
                     /gene="KATNBL1"
                     /gene_synonym="C15orf29"
                     /coded_by="XM_047433036.1:515..1429"
                     /db_xref="GeneID:79768"
                     /db_xref="HGNC:HGNC:26199"
                     /db_xref="MIM:616235"
ORIGIN      
        1 masethnvkk rnfcnkiedh fidlprkkis nftnknmkev kkspkqlaay inrtvgqtvk
       61 spdklrkviy rrkkvhhpfp npcyrkkqsp gsggcdmank enelacaghl peklhhdsrt
      121 ylvnssdsgs sqtespssky sgffsevsqd hetmaqvlfs rnmrlnvalt fwrkrsisel
      181 vayllriedl gvvvdclpvl tnclqeekqy islgccvdll plvksllksk feeyvivgln
      241 wlqavikrww selsskteii ndgniqilkq qlsglweqen hltlvpgytg niakdvdayl
      301 lqlh
//
LOCUS       XP_016878062             304 aa            linear   PRI 05-AUG-2025
DEFINITION  KATNB1-like protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_016878062
VERSION     XP_016878062.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022573.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..304
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..304
                     /product="KATNB1-like protein 1 isoform X1"
                     /calculated_mol_wt=34636
     Region          149..300
                     /region_name="Katanin_con80"
                     /note="con80 domain of Katanin; pfam13925"
                     /db_xref="CDD:464044"
     CDS             1..304
                     /gene="KATNBL1"
                     /gene_synonym="C15orf29"
                     /coded_by="XM_017022573.3:1098..2012"
                     /db_xref="GeneID:79768"
                     /db_xref="HGNC:HGNC:26199"
                     /db_xref="MIM:616235"
ORIGIN      
        1 masethnvkk rnfcnkiedh fidlprkkis nftnknmkev kkspkqlaay inrtvgqtvk
       61 spdklrkviy rrkkvhhpfp npcyrkkqsp gsggcdmank enelacaghl peklhhdsrt
      121 ylvnssdsgs sqtespssky sgffsevsqd hetmaqvlfs rnmrlnvalt fwrkrsisel
      181 vayllriedl gvvvdclpvl tnclqeekqy islgccvdll plvksllksk feeyvivgln
      241 wlqavikrww selsskteii ndgniqilkq qlsglweqen hltlvpgytg niakdvdayl
      301 lqlh
//
LOCUS       XP_047288993             304 aa            linear   PRI 05-AUG-2025
DEFINITION  KATNB1-like protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047288993
VERSION     XP_047288993.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433037.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..304
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..304
                     /product="KATNB1-like protein 1 isoform X1"
                     /calculated_mol_wt=34636
     Region          149..300
                     /region_name="Katanin_con80"
                     /note="con80 domain of Katanin; pfam13925"
                     /db_xref="CDD:464044"
     CDS             1..304
                     /gene="KATNBL1"
                     /gene_synonym="C15orf29"
                     /coded_by="XM_047433037.1:381..1295"
                     /db_xref="GeneID:79768"
                     /db_xref="HGNC:HGNC:26199"
                     /db_xref="MIM:616235"
ORIGIN      
        1 masethnvkk rnfcnkiedh fidlprkkis nftnknmkev kkspkqlaay inrtvgqtvk
       61 spdklrkviy rrkkvhhpfp npcyrkkqsp gsggcdmank enelacaghl peklhhdsrt
      121 ylvnssdsgs sqtespssky sgffsevsqd hetmaqvlfs rnmrlnvalt fwrkrsisel
      181 vayllriedl gvvvdclpvl tnclqeekqy islgccvdll plvksllksk feeyvivgln
      241 wlqavikrww selsskteii ndgniqilkq qlsglweqen hltlvpgytg niakdvdayl
      301 lqlh
//
LOCUS       XP_016878063             304 aa            linear   PRI 05-AUG-2025
DEFINITION  KATNB1-like protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_016878063
VERSION     XP_016878063.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022574.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..304
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..304
                     /product="KATNB1-like protein 1 isoform X1"
                     /calculated_mol_wt=34636
     Region          149..300
                     /region_name="Katanin_con80"
                     /note="con80 domain of Katanin; pfam13925"
                     /db_xref="CDD:464044"
     CDS             1..304
                     /gene="KATNBL1"
                     /gene_synonym="C15orf29"
                     /coded_by="XM_017022574.2:233..1147"
                     /db_xref="GeneID:79768"
                     /db_xref="HGNC:HGNC:26199"
                     /db_xref="MIM:616235"
ORIGIN      
        1 masethnvkk rnfcnkiedh fidlprkkis nftnknmkev kkspkqlaay inrtvgqtvk
       61 spdklrkviy rrkkvhhpfp npcyrkkqsp gsggcdmank enelacaghl peklhhdsrt
      121 ylvnssdsgs sqtespssky sgffsevsqd hetmaqvlfs rnmrlnvalt fwrkrsisel
      181 vayllriedl gvvvdclpvl tnclqeekqy islgccvdll plvksllksk feeyvivgln
      241 wlqavikrww selsskteii ndgniqilkq qlsglweqen hltlvpgytg niakdvdayl
      301 lqlh
//
LOCUS       XP_047288994             304 aa            linear   PRI 05-AUG-2025
DEFINITION  KATNB1-like protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047288994
VERSION     XP_047288994.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433038.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..304
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..304
                     /product="KATNB1-like protein 1 isoform X1"
                     /calculated_mol_wt=34636
     Region          149..300
                     /region_name="Katanin_con80"
                     /note="con80 domain of Katanin; pfam13925"
                     /db_xref="CDD:464044"
     CDS             1..304
                     /gene="KATNBL1"
                     /gene_synonym="C15orf29"
                     /coded_by="XM_047433038.1:258..1172"
                     /db_xref="GeneID:79768"
                     /db_xref="HGNC:HGNC:26199"
                     /db_xref="MIM:616235"
ORIGIN      
        1 masethnvkk rnfcnkiedh fidlprkkis nftnknmkev kkspkqlaay inrtvgqtvk
       61 spdklrkviy rrkkvhhpfp npcyrkkqsp gsggcdmank enelacaghl peklhhdsrt
      121 ylvnssdsgs sqtespssky sgffsevsqd hetmaqvlfs rnmrlnvalt fwrkrsisel
      181 vayllriedl gvvvdclpvl tnclqeekqy islgccvdll plvksllksk feeyvivgln
      241 wlqavikrww selsskteii ndgniqilkq qlsglweqen hltlvpgytg niakdvdayl
      301 lqlh
//
LOCUS       XP_005254725             298 aa            linear   PRI 05-AUG-2025
DEFINITION  KATNB1-like protein 1 isoform X2 [Homo sapiens].
ACCESSION   XP_005254725
VERSION     XP_005254725.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254668.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..298
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..298
                     /product="KATNB1-like protein 1 isoform X2"
                     /calculated_mol_wt=33882
     Region          149..296
                     /region_name="Katanin_con80"
                     /note="con80 domain of Katanin; pfam13925"
                     /db_xref="CDD:464044"
     CDS             1..298
                     /gene="KATNBL1"
                     /gene_synonym="C15orf29"
                     /coded_by="XM_005254668.5:161..1057"
                     /db_xref="GeneID:79768"
                     /db_xref="HGNC:HGNC:26199"
                     /db_xref="MIM:616235"
ORIGIN      
        1 masethnvkk rnfcnkiedh fidlprkkis nftnknmkev kkspkqlaay inrtvgqtvk
       61 spdklrkviy rrkkvhhpfp npcyrkkqsp gsggcdmank enelacaghl peklhhdsrt
      121 ylvnssdsgs sqtespssky sgffsevsqd hetmaqvlfs rnmrlnvalt fwrkrsisel
      181 vayllriedl gvvvdclpvl tnclqeekqy islgccvdll plvksllksk feeyvivgln
      241 wlqavikrww selsskteii ndgniqilkq qlsglweqen hltlvpgytg niakvlcv
//
LOCUS       XP_047288996             298 aa            linear   PRI 05-AUG-2025
DEFINITION  KATNB1-like protein 1 isoform X2 [Homo sapiens].
ACCESSION   XP_047288996
VERSION     XP_047288996.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433040.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..298
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..298
                     /product="KATNB1-like protein 1 isoform X2"
                     /calculated_mol_wt=33882
     Region          149..296
                     /region_name="Katanin_con80"
                     /note="con80 domain of Katanin; pfam13925"
                     /db_xref="CDD:464044"
     CDS             1..298
                     /gene="KATNBL1"
                     /gene_synonym="C15orf29"
                     /coded_by="XM_047433040.1:340..1236"
                     /db_xref="GeneID:79768"
                     /db_xref="HGNC:HGNC:26199"
                     /db_xref="MIM:616235"
ORIGIN      
        1 masethnvkk rnfcnkiedh fidlprkkis nftnknmkev kkspkqlaay inrtvgqtvk
       61 spdklrkviy rrkkvhhpfp npcyrkkqsp gsggcdmank enelacaghl peklhhdsrt
      121 ylvnssdsgs sqtespssky sgffsevsqd hetmaqvlfs rnmrlnvalt fwrkrsisel
      181 vayllriedl gvvvdclpvl tnclqeekqy islgccvdll plvksllksk feeyvivgln
      241 wlqavikrww selsskteii ndgniqilkq qlsglweqen hltlvpgytg niakvlcv
//
LOCUS       XP_016878064             227 aa            linear   PRI 05-AUG-2025
DEFINITION  KATNB1-like protein 1 isoform X3 [Homo sapiens].
ACCESSION   XP_016878064
VERSION     XP_016878064.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022575.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..227
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..227
                     /product="KATNB1-like protein 1 isoform X3"
                     /calculated_mol_wt=25915
     Region          149..>186
                     /region_name="Katanin_con80"
                     /note="con80 domain of Katanin; pfam13925"
                     /db_xref="CDD:464044"
     CDS             1..227
                     /gene="KATNBL1"
                     /gene_synonym="C15orf29"
                     /coded_by="XM_017022575.3:161..844"
                     /db_xref="GeneID:79768"
                     /db_xref="HGNC:HGNC:26199"
                     /db_xref="MIM:616235"
ORIGIN      
        1 masethnvkk rnfcnkiedh fidlprkkis nftnknmkev kkspkqlaay inrtvgqtvk
       61 spdklrkviy rrkkvhhpfp npcyrkkqsp gsggcdmank enelacaghl peklhhdsrt
      121 ylvnssdsgs sqtespssky sgffsevsqd hetmaqvlfs rnmrlnvalt fwrkrsisel
      181 vayllrniqi lkqqlsglwe qenhltlvpg ytgniakdvd ayllqlh
//
LOCUS       XP_047288997             227 aa            linear   PRI 05-AUG-2025
DEFINITION  KATNB1-like protein 1 isoform X3 [Homo sapiens].
ACCESSION   XP_047288997
VERSION     XP_047288997.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433041.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..227
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..227
                     /product="KATNB1-like protein 1 isoform X3"
                     /calculated_mol_wt=25915
     Region          149..>186
                     /region_name="Katanin_con80"
                     /note="con80 domain of Katanin; pfam13925"
                     /db_xref="CDD:464044"
     CDS             1..227
                     /gene="KATNBL1"
                     /gene_synonym="C15orf29"
                     /coded_by="XM_047433041.1:340..1023"
                     /db_xref="GeneID:79768"
                     /db_xref="HGNC:HGNC:26199"
                     /db_xref="MIM:616235"
ORIGIN      
        1 masethnvkk rnfcnkiedh fidlprkkis nftnknmkev kkspkqlaay inrtvgqtvk
       61 spdklrkviy rrkkvhhpfp npcyrkkqsp gsggcdmank enelacaghl peklhhdsrt
      121 ylvnssdsgs sqtespssky sgffsevsqd hetmaqvlfs rnmrlnvalt fwrkrsisel
      181 vayllrniqi lkqqlsglwe qenhltlvpg ytgniakdvd ayllqlh
//
LOCUS       XP_011520324            1041 aa            linear   PRI 05-AUG-2025
DEFINITION  SAFB-like transcription modulator isoform X1 [Homo sapiens].
ACCESSION   XP_011520324
VERSION     XP_011520324.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522022.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XP_011520324.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1041
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1041
                     /product="SAFB-like transcription modulator isoform X1"
                     /calculated_mol_wt=117776
     Region          22..56
                     /region_name="SAP"
                     /note="Putative DNA-binding (bihelical) motif predicted to
                     be involved in chromosomal organisation; smart00513"
                     /db_xref="CDD:128789"
     Region          <87..730
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          392..465
                     /region_name="RRM_SLTM"
                     /note="RNA recognition motif (RRM) found in Scaffold
                     attachment factor (SAF)-like transcription modulator
                     (SLTM) and similar proteins; cd12678"
                     /db_xref="CDD:410079"
     Region          805..>1040
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     CDS             1..1041
                     /gene="SLTM"
                     /gene_synonym="Met"
                     /coded_by="XM_011522022.2:115..3240"
                     /db_xref="GeneID:79811"
                     /db_xref="HGNC:HGNC:20709"
                     /db_xref="MIM:620992"
ORIGIN      
        1 maaatgavaa saasgqaegk kitdlrvidl kselkrrnld itgvktvlis rlkqaieeeg
       61 gdpdnieltv stdtpnkkpt kgkahfpsfa gkkheadels gdasveddaf ikdcelenqe
      121 aheqdgndel kdseefgene eenvhskell saeenkrahe lieaegiedi ekediesqei
      181 eaqegeddtf ltaqdgeeee nekdiagsgd gtqevskplp segslaeadh taheemeaht
      241 tvkeaeddni svtiqaedai tldfdgddll etgknvkitd seaskpkdgq daiaqspeke
      301 skdyemnanh kdgkkedcvk gdpvekeare sskkaesgdk ekdtlkkgps stgasgqaks
      361 sskeskdskt sskddkgsts stsgssgsst kniwvsglss ntkaadlknl fgkygkvlsa
      421 kvvtnarspg akcygivtms sstevsrcia hlhrtelhgq lisvekvkgd pskkemkken
      481 deksssrssg dkkntsdrss ktqasvkkee krsseksekk eskdtkkieg kdekndngas
      541 gqtsesikks eekkrissks pghmvildqt kgdhcrpsrr gryekihgrs kekerasldk
      601 krdkdyrrke ilpfekmkeq rlrehlvrfe rlrramelrr rreiaererr ereririire
      661 reererlqre rerleierqk lerermerer lereririeq errkeaeria rereelrrqq
      721 qqlryeqekr nslkrprdvd hrrddpywse nkklsldtda rfghgsdysr qqnrfndfdh
      781 rergrfpess avqsssferr drfvgqsegk karptarred psferypknf sdsrrneppp
      841 prnelresdr revrgerder rtviihdrpd ithprhprea gpnpsrptsw ksegsmstdk
      901 retrverper sgrevsghsv rgappgnrss asgygsregd rgvitdrggg sqhypeerhv
      961 verhgrdtsg prkewhgpps qgpsyhdtrr mgdgragagm itqhssnasp inrivqisgn
     1021 smprgsgsgf kpfkggpprr f
//
LOCUS       XP_011520325            1023 aa            linear   PRI 05-AUG-2025
DEFINITION  SAFB-like transcription modulator isoform X2 [Homo sapiens].
ACCESSION   XP_011520325
VERSION     XP_011520325.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522023.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XP_011520325.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1023
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1023
                     /product="SAFB-like transcription modulator isoform X2"
                     /calculated_mol_wt=116036
     Region          22..56
                     /region_name="SAP"
                     /note="Putative DNA-binding (bihelical) motif predicted to
                     be involved in chromosomal organisation; smart00513"
                     /db_xref="CDD:128789"
     Region          <34..712
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          374..447
                     /region_name="RRM_SLTM"
                     /note="RNA recognition motif (RRM) found in Scaffold
                     attachment factor (SAF)-like transcription modulator
                     (SLTM) and similar proteins; cd12678"
                     /db_xref="CDD:410079"
     Region          787..>1022
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     CDS             1..1023
                     /gene="SLTM"
                     /gene_synonym="Met"
                     /coded_by="XM_011522023.2:115..3186"
                     /db_xref="GeneID:79811"
                     /db_xref="HGNC:HGNC:20709"
                     /db_xref="MIM:620992"
ORIGIN      
        1 maaatgavaa saasgqaegk kitdlrvidl kselkrrnld itgvktvlis rlkqaieeeg
       61 gdpdnieltv stdtpnkkpt kgkahfpsfa gkkheadels gdasveddaf ikdcelenqe
      121 aheqdgndel kdseefgene eenvhskell saeenkrahe lieaegiedi ekediesqei
      181 eaqegeddtf ltaqdgeeee nekegslaea dhtaheemea httvkeaedd nisvtiqaed
      241 aitldfdgdd lletgknvki tdseaskpkd gqdaiaqspe keskdyemna nhkdgkkedc
      301 vkgdpvekea resskkaesg dkekdtlkkg psstgasgqa kssskeskds ktsskddkgs
      361 tsstsgssgs stkniwvsgl ssntkaadlk nlfgkygkvl sakvvtnars pgakcygivt
      421 mssstevsrc iahlhrtelh gqlisvekvk gdpskkemkk endeksssrs sgdkkntsdr
      481 ssktqasvkk eekrssekse kkeskdtkki egkdekndng asgqtsesik kseekkriss
      541 kspghmvild qtkgdhcrps rrgryekihg rskekerasl dkkrdkdyrr keilpfekmk
      601 eqrlrehlvr ferlrramel rrrreiaere rrereririi rereererlq rererleier
      661 qklerermer erlereriri eqerrkeaer iarereelrr qqqqlryeqe krnslkrprd
      721 vdhrrddpyw senkklsldt darfghgsdy srqqnrfndf dhrergrfpe ssavqsssfe
      781 rrdrfvgqse gkkarptarr edpsferypk nfsdsrrnep ppprnelres drrevrgerd
      841 errtviihdr pdithprhpr eagpnpsrpt swksegsmst dkretrverp ersgrevsgh
      901 svrgappgnr ssasgygsre gdrgvitdrg ggsqhypeer hvverhgrdt sgprkewhgp
      961 psqgpsyhdt rrmgdgraga gmitqhssna spinrivqis gnsmprgsgs gfkpfkggpp
     1021 rrf
//
LOCUS       XP_011520326             991 aa            linear   PRI 05-AUG-2025
DEFINITION  SAFB-like transcription modulator isoform X3 [Homo sapiens].
ACCESSION   XP_011520326
VERSION     XP_011520326.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522024.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XP_011520326.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..991
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..991
                     /product="SAFB-like transcription modulator isoform X3"
                     /calculated_mol_wt=112427
     Region          22..56
                     /region_name="SAP"
                     /note="Putative DNA-binding (bihelical) motif predicted to
                     be involved in chromosomal organisation; smart00513"
                     /db_xref="CDD:128789"
     Region          <147..704
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          392..>417
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:473069"
     Region          755..>990
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     CDS             1..991
                     /gene="SLTM"
                     /gene_synonym="Met"
                     /coded_by="XM_011522024.2:115..3090"
                     /db_xref="GeneID:79811"
                     /db_xref="HGNC:HGNC:20709"
                     /db_xref="MIM:620992"
ORIGIN      
        1 maaatgavaa saasgqaegk kitdlrvidl kselkrrnld itgvktvlis rlkqaieeeg
       61 gdpdnieltv stdtpnkkpt kgkahfpsfa gkkheadels gdasveddaf ikdcelenqe
      121 aheqdgndel kdseefgene eenvhskell saeenkrahe lieaegiedi ekediesqei
      181 eaqegeddtf ltaqdgeeee nekdiagsgd gtqevskplp segslaeadh taheemeaht
      241 tvkeaeddni svtiqaedai tldfdgddll etgknvkitd seaskpkdgq daiaqspeke
      301 skdyemnanh kdgkkedcvk gdpvekeare sskkaesgdk ekdtlkkgps stgasgqaks
      361 sskeskdskt sskddkgsts stsgssgsst kniwvsglss ntkaadlknl fgkygkvkgd
      421 pskkemkken deksssrssg dkkntsdrss ktqasvkkee krsseksekk eskdtkkieg
      481 kdekndngas gqtsesikks eekkrissks pghmvildqt kgdhcrpsrr gryekihgrs
      541 kekerasldk krdkdyrrke ilpfekmkeq rlrehlvrfe rlrramelrr rreiaererr
      601 ereririire reererlqre rerleierqk lerermerer lereririeq errkeaeria
      661 rereelrrqq qqlryeqekr nslkrprdvd hrrddpywse nkklsldtda rfghgsdysr
      721 qqnrfndfdh rergrfpess avqsssferr drfvgqsegk karptarred psferypknf
      781 sdsrrneppp prnelresdr revrgerder rtviihdrpd ithprhprea gpnpsrptsw
      841 ksegsmstdk retrverper sgrevsghsv rgappgnrss asgygsregd rgvitdrggg
      901 sqhypeerhv verhgrdtsg prkewhgpps qgpsyhdtrr mgdgragagm itqhssnasp
      961 inrivqisgn smprgsgsgf kpfkggpprr f
//
LOCUS       XP_047288999             984 aa            linear   PRI 05-AUG-2025
DEFINITION  SAFB-like transcription modulator isoform X4 [Homo sapiens].
ACCESSION   XP_047288999
VERSION     XP_047288999.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433043.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..984
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..984
                     /product="SAFB-like transcription modulator isoform X4"
                     /calculated_mol_wt=111669
     Region          22..56
                     /region_name="SAP"
                     /note="Putative DNA-binding (bihelical) motif predicted to
                     be involved in chromosomal organisation; smart00513"
                     /db_xref="CDD:128789"
     Region          <140..697
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          385..>410
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:473069"
     Region          748..>983
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     CDS             1..984
                     /gene="SLTM"
                     /gene_synonym="Met"
                     /coded_by="XM_047433043.1:115..3069"
                     /db_xref="GeneID:79811"
                     /db_xref="HGNC:HGNC:20709"
                     /db_xref="MIM:620992"
ORIGIN      
        1 maaatgavaa saasgqaegk kitdlrvidl kselkrrnld itgvktvlis rlkqaieeeg
       61 gdpdnieltv stdtpnkkpt kgkgkkhead elsgdasved dafikdcele nqeaheqdgn
      121 delkdseefg eneeenvhsk ellsaeenkr ahelieaegi ediekedies qeieaqeged
      181 dtfltaqdge eeenekdiag sgdgtqevsk plpsegslae adhtaheeme ahttvkeaed
      241 dnisvtiqae daitldfdgd dlletgknvk itdseaskpk dgqdaiaqsp ekeskdyemn
      301 anhkdgkked cvkgdpveke aresskkaes gdkekdtlkk gpsstgasgq akssskeskd
      361 sktsskddkg stsstsgssg sstkniwvsg lssntkaadl knlfgkygkv kgdpskkemk
      421 kendeksssr ssgdkkntsd rssktqasvk keekrsseks ekkeskdtkk iegkdekndn
      481 gasgqtsesi kkseekkris skspghmvil dqtkgdhcrp srrgryekih grskekeras
      541 ldkkrdkdyr rkeilpfekm keqrlrehlv rferlrrame lrrrreiaer errereriri
      601 irereererl qrererleie rqklererme rerlererir ieqerrkeae riarereelr
      661 rqqqqlryeq ekrnslkrpr dvdhrrddpy wsenkklsld tdarfghgsd ysrqqnrfnd
      721 fdhrergrfp essavqsssf errdrfvgqs egkkarptar redpsferyp knfsdsrrne
      781 pppprnelre sdrrevrger derrtviihd rpdithprhp reagpnpsrp tswksegsms
      841 tdkretrver persgrevsg hsvrgappgn rssasgygsr egdrgvitdr gggsqhypee
      901 rhvverhgrd tsgprkewhg ppsqgpsyhd trrmgdgrag agmitqhssn aspinrivqi
      961 sgnsmprgsg sgfkpfkggp prrf
//
LOCUS       XP_047289000             973 aa            linear   PRI 05-AUG-2025
DEFINITION  SAFB-like transcription modulator isoform X5 [Homo sapiens].
ACCESSION   XP_047289000
VERSION     XP_047289000.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433044.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..973
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..973
                     /product="SAFB-like transcription modulator isoform X5"
                     /calculated_mol_wt=110687
     Region          22..56
                     /region_name="SAP"
                     /note="Putative DNA-binding (bihelical) motif predicted to
                     be involved in chromosomal organisation; smart00513"
                     /db_xref="CDD:128789"
     Region          25..>183
                     /region_name="PLN03124"
                     /note="poly [ADP-ribose] polymerase; Provisional"
                     /db_xref="CDD:215591"
     Region          <146..686
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          374..>399
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:473069"
     Region          737..>972
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     CDS             1..973
                     /gene="SLTM"
                     /gene_synonym="Met"
                     /coded_by="XM_047433044.1:115..3036"
                     /db_xref="GeneID:79811"
                     /db_xref="HGNC:HGNC:20709"
                     /db_xref="MIM:620992"
ORIGIN      
        1 maaatgavaa saasgqaegk kitdlrvidl kselkrrnld itgvktvlis rlkqaieeeg
       61 gdpdnieltv stdtpnkkpt kgkahfpsfa gkkheadels gdasveddaf ikdcelenqe
      121 aheqdgndel kdseefgene eenvhskell saeenkrahe lieaegiedi ekediesqei
      181 eaqegeddtf ltaqdgeeee nekegslaea dhtaheemea httvkeaedd nisvtiqaed
      241 aitldfdgdd lletgknvki tdseaskpkd gqdaiaqspe keskdyemna nhkdgkkedc
      301 vkgdpvekea resskkaesg dkekdtlkkg psstgasgqa kssskeskds ktsskddkgs
      361 tsstsgssgs stkniwvsgl ssntkaadlk nlfgkygkvk gdpskkemkk endeksssrs
      421 sgdkkntsdr ssktqasvkk eekrssekse kkeskdtkki egkdekndng asgqtsesik
      481 kseekkriss kspghmvild qtkgdhcrps rrgryekihg rskekerasl dkkrdkdyrr
      541 keilpfekmk eqrlrehlvr ferlrramel rrrreiaere rrereririi rereererlq
      601 rererleier qklerermer erlereriri eqerrkeaer iarereelrr qqqqlryeqe
      661 krnslkrprd vdhrrddpyw senkklsldt darfghgsdy srqqnrfndf dhrergrfpe
      721 ssavqsssfe rrdrfvgqse gkkarptarr edpsferypk nfsdsrrnep ppprnelres
      781 drrevrgerd errtviihdr pdithprhpr eagpnpsrpt swksegsmst dkretrverp
      841 ersgrevsgh svrgappgnr ssasgygsre gdrgvitdrg ggsqhypeer hvverhgrdt
      901 sgprkewhgp psqgpsyhdt rrmgdgraga gmitqhssna spinrivqis gnsmprgsgs
      961 gfkpfkggpp rrf
//
LOCUS       XP_016878065             966 aa            linear   PRI 05-AUG-2025
DEFINITION  SAFB-like transcription modulator isoform X6 [Homo sapiens].
ACCESSION   XP_016878065
VERSION     XP_016878065.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022576.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..966
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..966
                     /product="SAFB-like transcription modulator isoform X6"
                     /calculated_mol_wt=109930
     Region          22..56
                     /region_name="SAP"
                     /note="Putative DNA-binding (bihelical) motif predicted to
                     be involved in chromosomal organisation; smart00513"
                     /db_xref="CDD:128789"
     Region          <139..679
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          367..>392
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:473069"
     Region          730..>965
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     CDS             1..966
                     /gene="SLTM"
                     /gene_synonym="Met"
                     /coded_by="XM_017022576.2:115..3015"
                     /db_xref="GeneID:79811"
                     /db_xref="HGNC:HGNC:20709"
                     /db_xref="MIM:620992"
ORIGIN      
        1 maaatgavaa saasgqaegk kitdlrvidl kselkrrnld itgvktvlis rlkqaieeeg
       61 gdpdnieltv stdtpnkkpt kgkgkkhead elsgdasved dafikdcele nqeaheqdgn
      121 delkdseefg eneeenvhsk ellsaeenkr ahelieaegi ediekedies qeieaqeged
      181 dtfltaqdge eeenekegsl aeadhtahee meahttvkea eddnisvtiq aedaitldfd
      241 gddlletgkn vkitdseask pkdgqdaiaq spekeskdye mnanhkdgkk edcvkgdpve
      301 kearesskka esgdkekdtl kkgpsstgas gqakssskes kdsktsskdd kgstsstsgs
      361 sgsstkniwv sglssntkaa dlknlfgkyg kvkgdpskke mkkendekss srssgdkknt
      421 sdrssktqas vkkeekrsse ksekkeskdt kkiegkdekn dngasgqtse sikkseekkr
      481 isskspghmv ildqtkgdhc rpsrrgryek ihgrskeker asldkkrdkd yrrkeilpfe
      541 kmkeqrlreh lvrferlrra melrrrreia ererrereri riirereere rlqrererle
      601 ierqklerer mererlerer irieqerrke aeriareree lrrqqqqlry eqekrnslkr
      661 prdvdhrrdd pywsenkkls ldtdarfghg sdysrqqnrf ndfdhrergr fpessavqss
      721 sferrdrfvg qsegkkarpt arredpsfer ypknfsdsrr nepppprnel resdrrevrg
      781 erderrtvii hdrpdithpr hpreagpnps rptswksegs mstdkretrv erpersgrev
      841 sghsvrgapp gnrssasgyg sregdrgvit drgggsqhyp eerhvverhg rdtsgprkew
      901 hgppsqgpsy hdtrrmgdgr agagmitqhs snaspinriv qisgnsmprg sgsgfkpfkg
      961 gpprrf
//
LOCUS       XP_011520329             959 aa            linear   PRI 05-AUG-2025
DEFINITION  SAFB-like transcription modulator isoform X7 [Homo sapiens].
ACCESSION   XP_011520329
VERSION     XP_011520329.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522027.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XP_011520329.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..959
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..959
                     /product="SAFB-like transcription modulator isoform X7"
                     /calculated_mol_wt=108389
     Region          22..56
                     /region_name="SAP"
                     /note="Putative DNA-binding (bihelical) motif predicted to
                     be involved in chromosomal organisation; smart00513"
                     /db_xref="CDD:128789"
     Region          25..>118
                     /region_name="PLN03124"
                     /note="poly [ADP-ribose] polymerase; Provisional"
                     /db_xref="CDD:215591"
     Region          <140..648
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          310..383
                     /region_name="RRM_SLTM"
                     /note="RNA recognition motif (RRM) found in Scaffold
                     attachment factor (SAF)-like transcription modulator
                     (SLTM) and similar proteins; cd12678"
                     /db_xref="CDD:410079"
     Region          723..>958
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     CDS             1..959
                     /gene="SLTM"
                     /gene_synonym="Met"
                     /coded_by="XM_011522027.2:115..2994"
                     /db_xref="GeneID:79811"
                     /db_xref="HGNC:HGNC:20709"
                     /db_xref="MIM:620992"
ORIGIN      
        1 maaatgavaa saasgqaegk kitdlrvidl kselkrrnld itgvktvlis rlkqaieeeg
       61 gdpdnieltv stdtpnkkpt kgkahfpsfa gkkheadels gdasveddaf ikdgeeeene
      121 kdiagsgdgt qevskplpse gslaeadhta heemeahttv keaeddnisv tiqaedaitl
      181 dfdgddllet gknvkitdse askpkdgqda iaqspekesk dyemnanhkd gkkedcvkgd
      241 pvekearess kkaesgdkek dtlkkgpsst gasgqaksss keskdsktss kddkgstsst
      301 sgssgsstkn iwvsglssnt kaadlknlfg kygkvlsakv vtnarspgak cygivtmsss
      361 tevsrciahl hrtelhgqli svekvkgdps kkemkkende ksssrssgdk kntsdrsskt
      421 qasvkkeekr sseksekkes kdtkkiegkd ekndngasgq tsesikksee kkrisskspg
      481 hmvildqtkg dhcrpsrrgr yekihgrske kerasldkkr dkdyrrkeil pfekmkeqrl
      541 rehlvrferl rramelrrrr eiaererrer eririirere ererlqrere rleierqkle
      601 rermererle reririeqer rkeaeriare reelrrqqqq lryeqekrns lkrprdvdhr
      661 rddpywsenk klsldtdarf ghgsdysrqq nrfndfdhre rgrfpessav qsssferrdr
      721 fvgqsegkka rptarredps ferypknfsd srrneppppr nelresdrre vrgerderrt
      781 viihdrpdit hprhpreagp npsrptswks egsmstdkre trverpersg revsghsvrg
      841 appgnrssas gygsregdrg vitdrgggsq hypeerhvve rhgrdtsgpr kewhgppsqg
      901 psyhdtrrmg dgragagmit qhssnaspin rivqisgnsm prgsgsgfkp fkggpprrf
//
LOCUS       XP_006720749             952 aa            linear   PRI 05-AUG-2025
DEFINITION  SAFB-like transcription modulator isoform X8 [Homo sapiens].
ACCESSION   XP_006720749
VERSION     XP_006720749.4
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720686.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XP_006720749.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..952
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..952
                     /product="SAFB-like transcription modulator isoform X8"
                     /calculated_mol_wt=107631
     Region          22..56
                     /region_name="SAP"
                     /note="Putative DNA-binding (bihelical) motif predicted to
                     be involved in chromosomal organisation; smart00513"
                     /db_xref="CDD:128789"
     Region          25..>174
                     /region_name="PLN03124"
                     /note="poly [ADP-ribose] polymerase; Provisional"
                     /db_xref="CDD:215591"
     Region          <133..641
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          303..376
                     /region_name="RRM_SLTM"
                     /note="RNA recognition motif (RRM) found in Scaffold
                     attachment factor (SAF)-like transcription modulator
                     (SLTM) and similar proteins; cd12678"
                     /db_xref="CDD:410079"
     Region          716..>951
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     CDS             1..952
                     /gene="SLTM"
                     /gene_synonym="Met"
                     /coded_by="XM_006720686.4:115..2973"
                     /db_xref="GeneID:79811"
                     /db_xref="HGNC:HGNC:20709"
                     /db_xref="MIM:620992"
ORIGIN      
        1 maaatgavaa saasgqaegk kitdlrvidl kselkrrnld itgvktvlis rlkqaieeeg
       61 gdpdnieltv stdtpnkkpt kgkgkkhead elsgdasved dafikdgeee enekdiagsg
      121 dgtqevskpl psegslaead htaheemeah ttvkeaeddn isvtiqaeda itldfdgddl
      181 letgknvkit dseaskpkdg qdaiaqspek eskdyemnan hkdgkkedcv kgdpvekear
      241 esskkaesgd kekdtlkkgp sstgasgqak ssskeskdsk tsskddkgst sstsgssgss
      301 tkniwvsgls sntkaadlkn lfgkygkvls akvvtnarsp gakcygivtm ssstevsrci
      361 ahlhrtelhg qlisvekvkg dpskkemkke ndeksssrss gdkkntsdrs sktqasvkke
      421 ekrsseksek keskdtkkie gkdekndnga sgqtsesikk seekkrissk spghmvildq
      481 tkgdhcrpsr rgryekihgr skekerasld kkrdkdyrrk eilpfekmke qrlrehlvrf
      541 erlrramelr rrreiaerer rereririir ereererlqr ererleierq klerermere
      601 rlereririe qerrkeaeri arereelrrq qqqlryeqek rnslkrprdv dhrrddpyws
      661 enkklsldtd arfghgsdys rqqnrfndfd hrergrfpes savqsssfer rdrfvgqseg
      721 kkarptarre dpsferypkn fsdsrrnepp pprnelresd rrevrgerde rrtviihdrp
      781 dithprhpre agpnpsrpts wksegsmstd kretrverpe rsgrevsghs vrgappgnrs
      841 sasgygsreg drgvitdrgg gsqhypeerh vverhgrdts gprkewhgpp sqgpsyhdtr
      901 rmgdgragag mitqhssnas pinrivqisg nsmprgsgsg fkpfkggppr rf
//
LOCUS       XP_011520330             941 aa            linear   PRI 05-AUG-2025
DEFINITION  SAFB-like transcription modulator isoform X9 [Homo sapiens].
ACCESSION   XP_011520330
VERSION     XP_011520330.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522028.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XP_011520330.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..941
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..941
                     /product="SAFB-like transcription modulator isoform X9"
                     /calculated_mol_wt=106649
     Region          22..56
                     /region_name="SAP"
                     /note="Putative DNA-binding (bihelical) motif predicted to
                     be involved in chromosomal organisation; smart00513"
                     /db_xref="CDD:128789"
     Region          25..>112
                     /region_name="PLN03124"
                     /note="poly [ADP-ribose] polymerase; Provisional"
                     /db_xref="CDD:215591"
     Region          <126..630
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          292..365
                     /region_name="RRM_SLTM"
                     /note="RNA recognition motif (RRM) found in Scaffold
                     attachment factor (SAF)-like transcription modulator
                     (SLTM) and similar proteins; cd12678"
                     /db_xref="CDD:410079"
     Region          705..>940
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     CDS             1..941
                     /gene="SLTM"
                     /gene_synonym="Met"
                     /coded_by="XM_011522028.2:115..2940"
                     /db_xref="GeneID:79811"
                     /db_xref="HGNC:HGNC:20709"
                     /db_xref="MIM:620992"
ORIGIN      
        1 maaatgavaa saasgqaegk kitdlrvidl kselkrrnld itgvktvlis rlkqaieeeg
       61 gdpdnieltv stdtpnkkpt kgkahfpsfa gkkheadels gdasveddaf ikdgeeeene
      121 kegslaeadh taheemeaht tvkeaeddni svtiqaedai tldfdgddll etgknvkitd
      181 seaskpkdgq daiaqspeke skdyemnanh kdgkkedcvk gdpvekeare sskkaesgdk
      241 ekdtlkkgps stgasgqaks sskeskdskt sskddkgsts stsgssgsst kniwvsglss
      301 ntkaadlknl fgkygkvlsa kvvtnarspg akcygivtms sstevsrcia hlhrtelhgq
      361 lisvekvkgd pskkemkken deksssrssg dkkntsdrss ktqasvkkee krsseksekk
      421 eskdtkkieg kdekndngas gqtsesikks eekkrissks pghmvildqt kgdhcrpsrr
      481 gryekihgrs kekerasldk krdkdyrrke ilpfekmkeq rlrehlvrfe rlrramelrr
      541 rreiaererr ereririire reererlqre rerleierqk lerermerer lereririeq
      601 errkeaeria rereelrrqq qqlryeqekr nslkrprdvd hrrddpywse nkklsldtda
      661 rfghgsdysr qqnrfndfdh rergrfpess avqsssferr drfvgqsegk karptarred
      721 psferypknf sdsrrneppp prnelresdr revrgerder rtviihdrpd ithprhprea
      781 gpnpsrptsw ksegsmstdk retrverper sgrevsghsv rgappgnrss asgygsregd
      841 rgvitdrggg sqhypeerhv verhgrdtsg prkewhgpps qgpsyhdtrr mgdgragagm
      901 itqhssnasp inrivqisgn smprgsgsgf kpfkggpprr f
//
LOCUS       XP_016878067             934 aa            linear   PRI 05-AUG-2025
DEFINITION  SAFB-like transcription modulator isoform X10 [Homo sapiens].
ACCESSION   XP_016878067
VERSION     XP_016878067.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022578.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XP_016878067.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..934
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..934
                     /product="SAFB-like transcription modulator isoform X10"
                     /calculated_mol_wt=105891
     Region          22..56
                     /region_name="SAP"
                     /note="Putative DNA-binding (bihelical) motif predicted to
                     be involved in chromosomal organisation; smart00513"
                     /db_xref="CDD:128789"
     Region          <119..623
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          285..358
                     /region_name="RRM_SLTM"
                     /note="RNA recognition motif (RRM) found in Scaffold
                     attachment factor (SAF)-like transcription modulator
                     (SLTM) and similar proteins; cd12678"
                     /db_xref="CDD:410079"
     Region          698..>933
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     CDS             1..934
                     /gene="SLTM"
                     /gene_synonym="Met"
                     /coded_by="XM_017022578.2:115..2919"
                     /db_xref="GeneID:79811"
                     /db_xref="HGNC:HGNC:20709"
                     /db_xref="MIM:620992"
ORIGIN      
        1 maaatgavaa saasgqaegk kitdlrvidl kselkrrnld itgvktvlis rlkqaieeeg
       61 gdpdnieltv stdtpnkkpt kgkgkkhead elsgdasved dafikdgeee enekegslae
      121 adhtaheeme ahttvkeaed dnisvtiqae daitldfdgd dlletgknvk itdseaskpk
      181 dgqdaiaqsp ekeskdyemn anhkdgkked cvkgdpveke aresskkaes gdkekdtlkk
      241 gpsstgasgq akssskeskd sktsskddkg stsstsgssg sstkniwvsg lssntkaadl
      301 knlfgkygkv lsakvvtnar spgakcygiv tmssstevsr ciahlhrtel hgqlisvekv
      361 kgdpskkemk kendeksssr ssgdkkntsd rssktqasvk keekrsseks ekkeskdtkk
      421 iegkdekndn gasgqtsesi kkseekkris skspghmvil dqtkgdhcrp srrgryekih
      481 grskekeras ldkkrdkdyr rkeilpfekm keqrlrehlv rferlrrame lrrrreiaer
      541 errereriri irereererl qrererleie rqklererme rerlererir ieqerrkeae
      601 riarereelr rqqqqlryeq ekrnslkrpr dvdhrrddpy wsenkklsld tdarfghgsd
      661 ysrqqnrfnd fdhrergrfp essavqsssf errdrfvgqs egkkarptar redpsferyp
      721 knfsdsrrne pppprnelre sdrrevrger derrtviihd rpdithprhp reagpnpsrp
      781 tswksegsms tdkretrver persgrevsg hsvrgappgn rssasgygsr egdrgvitdr
      841 gggsqhypee rhvverhgrd tsgprkewhg ppsqgpsyhd trrmgdgrag agmitqhssn
      901 aspinrivqi sgnsmprgsg sgfkpfkggp prrf
//
LOCUS       XP_047289001             902 aa            linear   PRI 05-AUG-2025
DEFINITION  SAFB-like transcription modulator isoform X11 [Homo sapiens].
ACCESSION   XP_047289001
VERSION     XP_047289001.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433045.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..902
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..902
                     /product="SAFB-like transcription modulator isoform X11"
                     /calculated_mol_wt=102283
     Region          22..56
                     /region_name="SAP"
                     /note="Putative DNA-binding (bihelical) motif predicted to
                     be involved in chromosomal organisation; smart00513"
                     /db_xref="CDD:128789"
     Region          25..>174
                     /region_name="PLN03124"
                     /note="poly [ADP-ribose] polymerase; Provisional"
                     /db_xref="CDD:215591"
     Region          <178..615
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          303..>328
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:473069"
     Region          666..>901
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     CDS             1..902
                     /gene="SLTM"
                     /gene_synonym="Met"
                     /coded_by="XM_047433045.1:115..2823"
                     /db_xref="GeneID:79811"
                     /db_xref="HGNC:HGNC:20709"
                     /db_xref="MIM:620992"
ORIGIN      
        1 maaatgavaa saasgqaegk kitdlrvidl kselkrrnld itgvktvlis rlkqaieeeg
       61 gdpdnieltv stdtpnkkpt kgkgkkhead elsgdasved dafikdgeee enekdiagsg
      121 dgtqevskpl psegslaead htaheemeah ttvkeaeddn isvtiqaeda itldfdgddl
      181 letgknvkit dseaskpkdg qdaiaqspek eskdyemnan hkdgkkedcv kgdpvekear
      241 esskkaesgd kekdtlkkgp sstgasgqak ssskeskdsk tsskddkgst sstsgssgss
      301 tkniwvsgls sntkaadlkn lfgkygkvkg dpskkemkke ndeksssrss gdkkntsdrs
      361 sktqasvkke ekrsseksek keskdtkkie gkdekndnga sgqtsesikk seekkrissk
      421 spghmvildq tkgdhcrpsr rgryekihgr skekerasld kkrdkdyrrk eilpfekmke
      481 qrlrehlvrf erlrramelr rrreiaerer rereririir ereererlqr ererleierq
      541 klerermere rlereririe qerrkeaeri arereelrrq qqqlryeqek rnslkrprdv
      601 dhrrddpyws enkklsldtd arfghgsdys rqqnrfndfd hrergrfpes savqsssfer
      661 rdrfvgqseg kkarptarre dpsferypkn fsdsrrnepp pprnelresd rrevrgerde
      721 rrtviihdrp dithprhpre agpnpsrpts wksegsmstd kretrverpe rsgrevsghs
      781 vrgappgnrs sasgygsreg drgvitdrgg gsqhypeerh vverhgrdts gprkewhgpp
      841 sqgpsyhdtr rmgdgragag mitqhssnas pinrivqisg nsmprgsgsg fkpfkggppr
      901 rf
//
LOCUS       XP_047289002             884 aa            linear   PRI 05-AUG-2025
DEFINITION  SAFB-like transcription modulator isoform X12 [Homo sapiens].
ACCESSION   XP_047289002
VERSION     XP_047289002.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433046.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..884
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..884
                     /product="SAFB-like transcription modulator isoform X12"
                     /calculated_mol_wt=100543
     Region          22..56
                     /region_name="SAP"
                     /note="Putative DNA-binding (bihelical) motif predicted to
                     be involved in chromosomal organisation; smart00513"
                     /db_xref="CDD:128789"
     Region          <160..597
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          285..>310
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:473069"
     Region          648..>883
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     CDS             1..884
                     /gene="SLTM"
                     /gene_synonym="Met"
                     /coded_by="XM_047433046.1:115..2769"
                     /db_xref="GeneID:79811"
                     /db_xref="HGNC:HGNC:20709"
                     /db_xref="MIM:620992"
ORIGIN      
        1 maaatgavaa saasgqaegk kitdlrvidl kselkrrnld itgvktvlis rlkqaieeeg
       61 gdpdnieltv stdtpnkkpt kgkgkkhead elsgdasved dafikdgeee enekegslae
      121 adhtaheeme ahttvkeaed dnisvtiqae daitldfdgd dlletgknvk itdseaskpk
      181 dgqdaiaqsp ekeskdyemn anhkdgkked cvkgdpveke aresskkaes gdkekdtlkk
      241 gpsstgasgq akssskeskd sktsskddkg stsstsgssg sstkniwvsg lssntkaadl
      301 knlfgkygkv kgdpskkemk kendeksssr ssgdkkntsd rssktqasvk keekrsseks
      361 ekkeskdtkk iegkdekndn gasgqtsesi kkseekkris skspghmvil dqtkgdhcrp
      421 srrgryekih grskekeras ldkkrdkdyr rkeilpfekm keqrlrehlv rferlrrame
      481 lrrrreiaer errereriri irereererl qrererleie rqklererme rerlererir
      541 ieqerrkeae riarereelr rqqqqlryeq ekrnslkrpr dvdhrrddpy wsenkklsld
      601 tdarfghgsd ysrqqnrfnd fdhrergrfp essavqsssf errdrfvgqs egkkarptar
      661 redpsferyp knfsdsrrne pppprnelre sdrrevrger derrtviihd rpdithprhp
      721 reagpnpsrp tswksegsms tdkretrver persgrevsg hsvrgappgn rssasgygsr
      781 egdrgvitdr gggsqhypee rhvverhgrd tsgprkewhg ppsqgpsyhd trrmgdgrag
      841 agmitqhssn aspinrivqi sgnsmprgsg sgfkpfkggp prrf
//
LOCUS       XP_011520331             988 aa            linear   PRI 05-AUG-2025
DEFINITION  SAFB-like transcription modulator isoform X13 [Homo sapiens].
ACCESSION   XP_011520331
VERSION     XP_011520331.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522029.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..988
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..988
                     /product="SAFB-like transcription modulator isoform X13"
                     /calculated_mol_wt=112259
     Region          <34..677
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          339..412
                     /region_name="RRM_SLTM"
                     /note="RNA recognition motif (RRM) found in Scaffold
                     attachment factor (SAF)-like transcription modulator
                     (SLTM) and similar proteins; cd12678"
                     /db_xref="CDD:410079"
     Region          752..>987
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     CDS             1..988
                     /gene="SLTM"
                     /gene_synonym="Met"
                     /coded_by="XM_011522029.3:261..3227"
                     /db_xref="GeneID:79811"
                     /db_xref="HGNC:HGNC:20709"
                     /db_xref="MIM:620992"
ORIGIN      
        1 maieeeggdp dnieltvstd tpnkkptkgk ahfpsfagkk headelsgda sveddafikd
       61 celenqeahe qdgndelkds eefgeneeen vhskellsae enkrahelie aegiedieke
      121 diesqeieaq egeddtflta qdgeeeenek diagsgdgtq evskplpseg slaeadhtah
      181 eemeahttvk eaeddnisvt iqaedaitld fdgddlletg knvkitdsea skpkdgqdai
      241 aqspekeskd yemnanhkdg kkedcvkgdp vekearessk kaesgdkekd tlkkgpsstg
      301 asgqaksssk eskdsktssk ddkgstssts gssgsstkni wvsglssntk aadlknlfgk
      361 ygkvlsakvv tnarspgakc ygivtmssst evsrciahlh rtelhgqlis vekvkgdpsk
      421 kemkkendek sssrssgdkk ntsdrssktq asvkkeekrs seksekkesk dtkkiegkde
      481 kndngasgqt sesikkseek krisskspgh mvildqtkgd hcrpsrrgry ekihgrskek
      541 erasldkkrd kdyrrkeilp fekmkeqrlr ehlvrferlr ramelrrrre iaererrere
      601 ririireree rerlqrerer leierqkler ermererler eririeqerr keaeriarer
      661 eelrrqqqql ryeqekrnsl krprdvdhrr ddpywsenkk lsldtdarfg hgsdysrqqn
      721 rfndfdhrer grfpessavq sssferrdrf vgqsegkkar ptarredpsf erypknfsds
      781 rrnepppprn elresdrrev rgerderrtv iihdrpdith prhpreagpn psrptswkse
      841 gsmstdkret rverpersgr evsghsvrga ppgnrssasg ygsregdrgv itdrgggsqh
      901 ypeerhvver hgrdtsgprk ewhgppsqgp syhdtrrmgd gragagmitq hssnaspinr
      961 ivqisgnsmp rgsgsgfkpf kggpprrf
//
LOCUS       XP_016878068             981 aa            linear   PRI 05-AUG-2025
DEFINITION  SAFB-like transcription modulator isoform X14 [Homo sapiens].
ACCESSION   XP_016878068
VERSION     XP_016878068.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022579.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..981
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..981
                     /product="SAFB-like transcription modulator isoform X14"
                     /calculated_mol_wt=111501
     Region          <57..670
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          332..405
                     /region_name="RRM_SLTM"
                     /note="RNA recognition motif (RRM) found in Scaffold
                     attachment factor (SAF)-like transcription modulator
                     (SLTM) and similar proteins; cd12678"
                     /db_xref="CDD:410079"
     Region          745..>980
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     CDS             1..981
                     /gene="SLTM"
                     /gene_synonym="Met"
                     /coded_by="XM_017022579.2:261..3206"
                     /db_xref="GeneID:79811"
                     /db_xref="HGNC:HGNC:20709"
                     /db_xref="MIM:620992"
ORIGIN      
        1 maieeeggdp dnieltvstd tpnkkptkgk gkkheadels gdasveddaf ikdcelenqe
       61 aheqdgndel kdseefgene eenvhskell saeenkrahe lieaegiedi ekediesqei
      121 eaqegeddtf ltaqdgeeee nekdiagsgd gtqevskplp segslaeadh taheemeaht
      181 tvkeaeddni svtiqaedai tldfdgddll etgknvkitd seaskpkdgq daiaqspeke
      241 skdyemnanh kdgkkedcvk gdpvekeare sskkaesgdk ekdtlkkgps stgasgqaks
      301 sskeskdskt sskddkgsts stsgssgsst kniwvsglss ntkaadlknl fgkygkvlsa
      361 kvvtnarspg akcygivtms sstevsrcia hlhrtelhgq lisvekvkgd pskkemkken
      421 deksssrssg dkkntsdrss ktqasvkkee krsseksekk eskdtkkieg kdekndngas
      481 gqtsesikks eekkrissks pghmvildqt kgdhcrpsrr gryekihgrs kekerasldk
      541 krdkdyrrke ilpfekmkeq rlrehlvrfe rlrramelrr rreiaererr ereririire
      601 reererlqre rerleierqk lerermerer lereririeq errkeaeria rereelrrqq
      661 qqlryeqekr nslkrprdvd hrrddpywse nkklsldtda rfghgsdysr qqnrfndfdh
      721 rergrfpess avqsssferr drfvgqsegk karptarred psferypknf sdsrrneppp
      781 prnelresdr revrgerder rtviihdrpd ithprhprea gpnpsrptsw ksegsmstdk
      841 retrverper sgrevsghsv rgappgnrss asgygsregd rgvitdrggg sqhypeerhv
      901 verhgrdtsg prkewhgpps qgpsyhdtrr mgdgragagm itqhssnasp inrivqisgn
      961 smprgsgsgf kpfkggpprr f
//
LOCUS       XP_047289004             963 aa            linear   PRI 05-AUG-2025
DEFINITION  SAFB-like transcription modulator isoform X15 [Homo sapiens].
ACCESSION   XP_047289004
VERSION     XP_047289004.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433048.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..963
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..963
                     /product="SAFB-like transcription modulator isoform X15"
                     /calculated_mol_wt=109761
     Region          <92..676
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          314..387
                     /region_name="RRM_SLTM"
                     /note="RNA recognition motif (RRM) found in Scaffold
                     attachment factor (SAF)-like transcription modulator
                     (SLTM) and similar proteins; cd12678"
                     /db_xref="CDD:410079"
     Region          727..>962
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     CDS             1..963
                     /gene="SLTM"
                     /gene_synonym="Met"
                     /coded_by="XM_047433048.1:261..3152"
                     /db_xref="GeneID:79811"
                     /db_xref="HGNC:HGNC:20709"
                     /db_xref="MIM:620992"
ORIGIN      
        1 maieeeggdp dnieltvstd tpnkkptkgk gkkheadels gdasveddaf ikdcelenqe
       61 aheqdgndel kdseefgene eenvhskell saeenkrahe lieaegiedi ekediesqei
      121 eaqegeddtf ltaqdgeeee nekegslaea dhtaheemea httvkeaedd nisvtiqaed
      181 aitldfdgdd lletgknvki tdseaskpkd gqdaiaqspe keskdyemna nhkdgkkedc
      241 vkgdpvekea resskkaesg dkekdtlkkg psstgasgqa kssskeskds ktsskddkgs
      301 tsstsgssgs stkniwvsgl ssntkaadlk nlfgkygkvl sakvvtnars pgakcygivt
      361 mssstevsrc iahlhrtelh gqlisvekvk gdpskkemkk endeksssrs sgdkkntsdr
      421 ssktqasvkk eekrssekse kkeskdtkki egkdekndng asgqtsesik kseekkriss
      481 kspghmvild qtkgdhcrps rrgryekihg rskekerasl dkkrdkdyrr keilpfekmk
      541 eqrlrehlvr ferlrramel rrrreiaere rrereririi rereererlq rererleier
      601 qklerermer erlereriri eqerrkeaer iarereelrr qqqqlryeqe krnslkrprd
      661 vdhrrddpyw senkklsldt darfghgsdy srqqnrfndf dhrergrfpe ssavqsssfe
      721 rrdrfvgqse gkkarptarr edpsferypk nfsdsrrnep ppprnelres drrevrgerd
      781 errtviihdr pdithprhpr eagpnpsrpt swksegsmst dkretrverp ersgrevsgh
      841 svrgappgnr ssasgygsre gdrgvitdrg ggsqhypeer hvverhgrdt sgprkewhgp
      901 psqgpsyhdt rrmgdgraga gmitqhssna spinrivqis gnsmprgsgs gfkpfkggpp
      961 rrf
//
LOCUS       XP_011520332             804 aa            linear   PRI 05-AUG-2025
DEFINITION  SAFB-like transcription modulator isoform X16 [Homo sapiens].
ACCESSION   XP_011520332
VERSION     XP_011520332.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522030.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XP_011520332.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..804
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..804
                     /product="SAFB-like transcription modulator isoform X16"
                     /calculated_mol_wt=91233
     Region          22..56
                     /region_name="SAP"
                     /note="Putative DNA-binding (bihelical) motif predicted to
                     be involved in chromosomal organisation; smart00513"
                     /db_xref="CDD:128789"
     Region          <152..754
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          392..465
                     /region_name="RRM_SLTM"
                     /note="RNA recognition motif (RRM) found in Scaffold
                     attachment factor (SAF)-like transcription modulator
                     (SLTM) and similar proteins; cd12678"
                     /db_xref="CDD:410079"
     CDS             1..804
                     /gene="SLTM"
                     /gene_synonym="Met"
                     /coded_by="XM_011522030.3:115..2529"
                     /db_xref="GeneID:79811"
                     /db_xref="HGNC:HGNC:20709"
                     /db_xref="MIM:620992"
ORIGIN      
        1 maaatgavaa saasgqaegk kitdlrvidl kselkrrnld itgvktvlis rlkqaieeeg
       61 gdpdnieltv stdtpnkkpt kgkahfpsfa gkkheadels gdasveddaf ikdcelenqe
      121 aheqdgndel kdseefgene eenvhskell saeenkrahe lieaegiedi ekediesqei
      181 eaqegeddtf ltaqdgeeee nekdiagsgd gtqevskplp segslaeadh taheemeaht
      241 tvkeaeddni svtiqaedai tldfdgddll etgknvkitd seaskpkdgq daiaqspeke
      301 skdyemnanh kdgkkedcvk gdpvekeare sskkaesgdk ekdtlkkgps stgasgqaks
      361 sskeskdskt sskddkgsts stsgssgsst kniwvsglss ntkaadlknl fgkygkvlsa
      421 kvvtnarspg akcygivtms sstevsrcia hlhrtelhgq lisvekvkgd pskkemkken
      481 deksssrssg dkkntsdrss ktqasvkkee krsseksekk eskdtkkieg kdekndngas
      541 gqtsesikks eekkrissks pghmvildqt kgdhcrpsrr gryekihgrs kekerasldk
      601 krdkdyrrke ilpfekmkeq rlrehlvrfe rlrramelrr rreiaererr ereririire
      661 reererlqre rerleierqk lerermerer lereririeq errkeaeria rereelrrqq
      721 qqlryeqekr nslkrprdvd hrrddpywse nkklsldtda rfghgsdysr qqnrfndfdh
      781 rergrfpess avqsssferl crqs
//
LOCUS       XP_047289005             899 aa            linear   PRI 05-AUG-2025
DEFINITION  SAFB-like transcription modulator isoform X17 [Homo sapiens].
ACCESSION   XP_047289005
VERSION     XP_047289005.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433049.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..899
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..899
                     /product="SAFB-like transcription modulator isoform X17"
                     /calculated_mol_wt=102115
     Region          <80..588
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          250..323
                     /region_name="RRM_SLTM"
                     /note="RNA recognition motif (RRM) found in Scaffold
                     attachment factor (SAF)-like transcription modulator
                     (SLTM) and similar proteins; cd12678"
                     /db_xref="CDD:410079"
     Region          663..>898
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     CDS             1..899
                     /gene="SLTM"
                     /gene_synonym="Met"
                     /coded_by="XM_047433049.1:261..2960"
                     /db_xref="GeneID:79811"
                     /db_xref="HGNC:HGNC:20709"
                     /db_xref="MIM:620992"
ORIGIN      
        1 maieeeggdp dnieltvstd tpnkkptkgk gkkheadels gdasveddaf ikdgeeeene
       61 kdiagsgdgt qevskplpse gslaeadhta heemeahttv keaeddnisv tiqaedaitl
      121 dfdgddllet gknvkitdse askpkdgqda iaqspekesk dyemnanhkd gkkedcvkgd
      181 pvekearess kkaesgdkek dtlkkgpsst gasgqaksss keskdsktss kddkgstsst
      241 sgssgsstkn iwvsglssnt kaadlknlfg kygkvlsakv vtnarspgak cygivtmsss
      301 tevsrciahl hrtelhgqli svekvkgdps kkemkkende ksssrssgdk kntsdrsskt
      361 qasvkkeekr sseksekkes kdtkkiegkd ekndngasgq tsesikksee kkrisskspg
      421 hmvildqtkg dhcrpsrrgr yekihgrske kerasldkkr dkdyrrkeil pfekmkeqrl
      481 rehlvrferl rramelrrrr eiaererrer eririirere ererlqrere rleierqkle
      541 rermererle reririeqer rkeaeriare reelrrqqqq lryeqekrns lkrprdvdhr
      601 rddpywsenk klsldtdarf ghgsdysrqq nrfndfdhre rgrfpessav qsssferrdr
      661 fvgqsegkka rptarredps ferypknfsd srrneppppr nelresdrre vrgerderrt
      721 viihdrpdit hprhpreagp npsrptswks egsmstdkre trverpersg revsghsvrg
      781 appgnrssas gygsregdrg vitdrgggsq hypeerhvve rhgrdtsgpr kewhgppsqg
      841 psyhdtrrmg dgragagmit qhssnaspin rivqisgnsm prgsgsgfkp fkggpprrf
//
LOCUS       XP_047289006             672 aa            linear   PRI 05-AUG-2025
DEFINITION  SAFB-like transcription modulator isoform X18 [Homo sapiens].
ACCESSION   XP_047289006
VERSION     XP_047289006.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433050.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..672
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..672
                     /product="SAFB-like transcription modulator isoform X18"
                     /calculated_mol_wt=73844
     Region          22..56
                     /region_name="SAP"
                     /note="Putative DNA-binding (bihelical) motif predicted to
                     be involved in chromosomal organisation; smart00513"
                     /db_xref="CDD:128789"
     Region          25..>222
                     /region_name="PLN03124"
                     /note="poly [ADP-ribose] polymerase; Provisional"
                     /db_xref="CDD:215591"
     Region          392..465
                     /region_name="RRM_SLTM"
                     /note="RNA recognition motif (RRM) found in Scaffold
                     attachment factor (SAF)-like transcription modulator
                     (SLTM) and similar proteins; cd12678"
                     /db_xref="CDD:410079"
     CDS             1..672
                     /gene="SLTM"
                     /gene_synonym="Met"
                     /coded_by="XM_047433050.1:115..2133"
                     /db_xref="GeneID:79811"
                     /db_xref="HGNC:HGNC:20709"
                     /db_xref="MIM:620992"
ORIGIN      
        1 maaatgavaa saasgqaegk kitdlrvidl kselkrrnld itgvktvlis rlkqaieeeg
       61 gdpdnieltv stdtpnkkpt kgkahfpsfa gkkheadels gdasveddaf ikdcelenqe
      121 aheqdgndel kdseefgene eenvhskell saeenkrahe lieaegiedi ekediesqei
      181 eaqegeddtf ltaqdgeeee nekdiagsgd gtqevskplp segslaeadh taheemeaht
      241 tvkeaeddni svtiqaedai tldfdgddll etgknvkitd seaskpkdgq daiaqspeke
      301 skdyemnanh kdgkkedcvk gdpvekeare sskkaesgdk ekdtlkkgps stgasgqaks
      361 sskeskdskt sskddkgsts stsgssgsst kniwvsglss ntkaadlknl fgkygkvlsa
      421 kvvtnarspg akcygivtms sstevsrcia hlhrtelhgq lisvekvkgd pskkemkken
      481 deksssrssg dkkntsdrss ktqasvkkee krsseksekk eskdtkkieg kdekndngas
      541 gqtsesikks eekkrissks pghmvildqt kgdhcrpsrr gryekihgrs kekerasldk
      601 krdkdyrrke ilpfekmkeq rlrehlvrfe rlrramelrr nvvrklngll ekernsegnn
      661 ssfvmnkkkg ip
//
LOCUS       XP_047289007             806 aa            linear   PRI 05-AUG-2025
DEFINITION  SAFB-like transcription modulator isoform X19 [Homo sapiens].
ACCESSION   XP_047289007
VERSION     XP_047289007.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433051.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 6% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..806
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..806
                     /product="SAFB-like transcription modulator isoform X19"
                     /calculated_mol_wt=92296
     Region          <8..495
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          157..230
                     /region_name="RRM_SLTM"
                     /note="RNA recognition motif (RRM) found in Scaffold
                     attachment factor (SAF)-like transcription modulator
                     (SLTM) and similar proteins; cd12678"
                     /db_xref="CDD:410079"
     Region          570..>805
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     CDS             1..806
                     /gene="SLTM"
                     /gene_synonym="Met"
                     /coded_by="XM_047433051.1:711..3131"
                     /db_xref="GeneID:79811"
                     /db_xref="HGNC:HGNC:20709"
                     /db_xref="MIM:620992"
ORIGIN      
        1 meahttvkea eddnisvtiq aedaitldfd gddlletgkn vkitdseask pkdgqdaiaq
       61 spekeskdye mnanhkdgkk edcvkgdpve kearesskka esgdkekdtl kkgpsstgas
      121 gqakssskes kdsktsskdd kgstsstsgs sgsstkniwv sglssntkaa dlknlfgkyg
      181 kvlsakvvtn arspgakcyg ivtmssstev srciahlhrt elhgqlisve kvkgdpskke
      241 mkkendekss srssgdkknt sdrssktqas vkkeekrsse ksekkeskdt kkiegkdekn
      301 dngasgqtse sikkseekkr isskspghmv ildqtkgdhc rpsrrgryek ihgrskeker
      361 asldkkrdkd yrrkeilpfe kmkeqrlreh lvrferlrra melrrrreia ererrereri
      421 riirereere rlqrererle ierqklerer mererlerer irieqerrke aeriareree
      481 lrrqqqqlry eqekrnslkr prdvdhrrdd pywsenkkls ldtdarfghg sdysrqqnrf
      541 ndfdhrergr fpessavqss sferrdrfvg qsegkkarpt arredpsfer ypknfsdsrr
      601 nepppprnel resdrrevrg erderrtvii hdrpdithpr hpreagpnps rptswksegs
      661 mstdkretrv erpersgrev sghsvrgapp gnrssasgyg sregdrgvit drgggsqhyp
      721 eerhvverhg rdtsgprkew hgppsqgpsy hdtrrmgdgr agagmitqhs snaspinriv
      781 qisgnsmprg sgsgfkpfkg gpprrf
//
LOCUS       XP_047289008             806 aa            linear   PRI 05-AUG-2025
DEFINITION  SAFB-like transcription modulator isoform X19 [Homo sapiens].
ACCESSION   XP_047289008
VERSION     XP_047289008.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433052.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..806
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..806
                     /product="SAFB-like transcription modulator isoform X19"
                     /calculated_mol_wt=92296
     Region          <8..495
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          157..230
                     /region_name="RRM_SLTM"
                     /note="RNA recognition motif (RRM) found in Scaffold
                     attachment factor (SAF)-like transcription modulator
                     (SLTM) and similar proteins; cd12678"
                     /db_xref="CDD:410079"
     Region          570..>805
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     CDS             1..806
                     /gene="SLTM"
                     /gene_synonym="Met"
                     /coded_by="XM_047433052.1:1114..3534"
                     /db_xref="GeneID:79811"
                     /db_xref="HGNC:HGNC:20709"
                     /db_xref="MIM:620992"
ORIGIN      
        1 meahttvkea eddnisvtiq aedaitldfd gddlletgkn vkitdseask pkdgqdaiaq
       61 spekeskdye mnanhkdgkk edcvkgdpve kearesskka esgdkekdtl kkgpsstgas
      121 gqakssskes kdsktsskdd kgstsstsgs sgsstkniwv sglssntkaa dlknlfgkyg
      181 kvlsakvvtn arspgakcyg ivtmssstev srciahlhrt elhgqlisve kvkgdpskke
      241 mkkendekss srssgdkknt sdrssktqas vkkeekrsse ksekkeskdt kkiegkdekn
      301 dngasgqtse sikkseekkr isskspghmv ildqtkgdhc rpsrrgryek ihgrskeker
      361 asldkkrdkd yrrkeilpfe kmkeqrlreh lvrferlrra melrrrreia ererrereri
      421 riirereere rlqrererle ierqklerer mererlerer irieqerrke aeriareree
      481 lrrqqqqlry eqekrnslkr prdvdhrrdd pywsenkkls ldtdarfghg sdysrqqnrf
      541 ndfdhrergr fpessavqss sferrdrfvg qsegkkarpt arredpsfer ypknfsdsrr
      601 nepppprnel resdrrevrg erderrtvii hdrpdithpr hpreagpnps rptswksegs
      661 mstdkretrv erpersgrev sghsvrgapp gnrssasgyg sregdrgvit drgggsqhyp
      721 eerhvverhg rdtsgprkew hgppsqgpsy hdtrrmgdgr agagmitqhs snaspinriv
      781 qisgnsmprg sgsgfkpfkg gpprrf
//
LOCUS       XP_011520333             806 aa            linear   PRI 05-AUG-2025
DEFINITION  SAFB-like transcription modulator isoform X19 [Homo sapiens].
ACCESSION   XP_011520333
VERSION     XP_011520333.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522031.3
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 6% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..806
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..806
                     /product="SAFB-like transcription modulator isoform X19"
                     /calculated_mol_wt=92296
     Region          <8..495
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          157..230
                     /region_name="RRM_SLTM"
                     /note="RNA recognition motif (RRM) found in Scaffold
                     attachment factor (SAF)-like transcription modulator
                     (SLTM) and similar proteins; cd12678"
                     /db_xref="CDD:410079"
     Region          570..>805
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     CDS             1..806
                     /gene="SLTM"
                     /gene_synonym="Met"
                     /coded_by="XM_011522031.3:465..2885"
                     /db_xref="GeneID:79811"
                     /db_xref="HGNC:HGNC:20709"
                     /db_xref="MIM:620992"
ORIGIN      
        1 meahttvkea eddnisvtiq aedaitldfd gddlletgkn vkitdseask pkdgqdaiaq
       61 spekeskdye mnanhkdgkk edcvkgdpve kearesskka esgdkekdtl kkgpsstgas
      121 gqakssskes kdsktsskdd kgstsstsgs sgsstkniwv sglssntkaa dlknlfgkyg
      181 kvlsakvvtn arspgakcyg ivtmssstev srciahlhrt elhgqlisve kvkgdpskke
      241 mkkendekss srssgdkknt sdrssktqas vkkeekrsse ksekkeskdt kkiegkdekn
      301 dngasgqtse sikkseekkr isskspghmv ildqtkgdhc rpsrrgryek ihgrskeker
      361 asldkkrdkd yrrkeilpfe kmkeqrlreh lvrferlrra melrrrreia ererrereri
      421 riirereere rlqrererle ierqklerer mererlerer irieqerrke aeriareree
      481 lrrqqqqlry eqekrnslkr prdvdhrrdd pywsenkkls ldtdarfghg sdysrqqnrf
      541 ndfdhrergr fpessavqss sferrdrfvg qsegkkarpt arredpsfer ypknfsdsrr
      601 nepppprnel resdrrevrg erderrtvii hdrpdithpr hpreagpnps rptswksegs
      661 mstdkretrv erpersgrev sghsvrgapp gnrssasgyg sregdrgvit drgggsqhyp
      721 eerhvverhg rdtsgprkew hgppsqgpsy hdtrrmgdgr agagmitqhs snaspinriv
      781 qisgnsmprg sgsgfkpfkg gpprrf
//
LOCUS       XP_011520336            1746 aa            linear   PRI 05-AUG-2025
DEFINITION  inactive tyrosine-protein kinase PEAK1 isoform X1 [Homo sapiens].
ACCESSION   XP_011520336
VERSION     XP_011520336.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522034.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1746
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1746
                     /product="inactive tyrosine-protein kinase PEAK1 isoform
                     X1"
                     /calculated_mol_wt=192976
     Region          <1503..1668
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..1746
                     /gene="PEAK1"
                     /gene_synonym="SGK269"
                     /coded_by="XM_011522034.3:1055..6295"
                     /db_xref="GeneID:79834"
                     /db_xref="HGNC:HGNC:29431"
                     /db_xref="MIM:614248"
ORIGIN      
        1 msacntfteh vwkpgecknc fkpkslhqlp pdpekapith gnvktnanhs nnhrirntgn
       61 frppvakkpt iavkptmiva dgqsicgels iqehcenkpv iigwnrnraa lsqkplnnnn
      121 eddegishvp kpygnndsak kmsdnnnglt evlkeiagld tapqirgnet nsretflgri
      181 ndcykrsler klppscmigg iketqgkhvi lsgstevisn eggrfcypef ssgeeseedv
      241 lfsnmeeehe swdesdeell ameirmrgqp rfanfrantl spvrffvdkk wntiplrnks
      301 lqricavdyd dsydeilngy eensvvsygq gsiqsmvssd stspdsslte esrsetassl
      361 sqkicnggls pgnpgdskdm keiepnyesp ssnnqdkdss qaskssikvp ethkavlalr
      421 leekdgkiav qtekeeskas tdvagqavti nlvpteeqak pyrvvnleqp lckpytvvdv
      481 saamasehle gpvnspktks ssstpnspvt sssltpgqis ahfqkssair yqevwtssts
      541 prqkipkvel itsgtgpnvp prknchksap tsptatniss ktipvkspnl seikfnsynn
      601 agmppfpiii hdeptyarss knaikvpivi npnaydnlai yksflgtsge lsvkekttsv
      661 ishtyeeiet eskvpdntts kttdclqtkg fsnstehkrg svaqkvqefn nclnrgqssp
      721 qrsyssshss pakiqratqe pvakiegtqe sqmvgssstr ekastvlsqi vasiqppqsp
      781 petpqsgpka csveelyaip pdadvakstp kstpvrpksl ftsqpsgeae apqttdsptt
      841 kvqkdpsikp vtpspsklvt spqseppapf ppprstsspy hagnllqrhf tnwtkptspt
      901 rsteaesvlh segsrraada kpkrwisfks ffrrrktdee ddkekerekg klvgldgtvi
      961 hmlppppvqr hhwfteakge ssekpaivfm yrcdpaqgql svdqskartd qaavmekgra
     1021 enallqdsek krshsspsqi pkkilshmth evtedfsprd prtvvgkqdg rgctsvttal
     1081 slpeleredg kedisdpmdp npcsatysnl gqsraamipp kqprqpkgav ddaiafggkt
     1141 dqeapnasqp tppplpkkmi irantepisk dlqksmessl cvmanptydi dpnwdassag
     1201 ssisyelkgl diesydsler plrkerpvps aansissltt lsikdrfsns meslssrrgp
     1261 scrqgrgiqk pqrqalyrgl enreevvgki rslhtdalkk lavkcedlfm agqkdqlrfg
     1321 vdswsdfrlt sdkpcceagd avyytasyak dplnnyavki ckskakesqq yyhslavrqs
     1381 lavhfniqqd cghflaevpn rllpwedpdd pekdeddmee teedakgetd gknpkpcsea
     1441 assqkenqgv mskkqrshvv vitrevpclt vadfvrdsla qhgkspdlye rqvcllllql
     1501 csglehlkpy hvthcdlrle nlllvhyqpg gtaqgfgpae psptssyptr livsnfsqak
     1561 qkshlvdpei lrdqsrlape iitatqykkc defqtgiliy emlhlpnpfd enpelkerey
     1621 tradlpripf rspysrglqq lascllnpnp serilisdak gilqcllwgp redlfqtfta
     1681 cpslvqrntl lqnwldikrt llmikfaeks ldreggisle dwlcaqylaf attdslsciv
     1741 kilqhr
//
LOCUS       XP_047289010            1746 aa            linear   PRI 05-AUG-2025
DEFINITION  inactive tyrosine-protein kinase PEAK1 isoform X1 [Homo sapiens].
ACCESSION   XP_047289010
VERSION     XP_047289010.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433054.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1746
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1746
                     /product="inactive tyrosine-protein kinase PEAK1 isoform
                     X1"
                     /calculated_mol_wt=192976
     Region          <1503..1668
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..1746
                     /gene="PEAK1"
                     /gene_synonym="SGK269"
                     /coded_by="XM_047433054.1:896..6136"
                     /db_xref="GeneID:79834"
                     /db_xref="HGNC:HGNC:29431"
                     /db_xref="MIM:614248"
ORIGIN      
        1 msacntfteh vwkpgecknc fkpkslhqlp pdpekapith gnvktnanhs nnhrirntgn
       61 frppvakkpt iavkptmiva dgqsicgels iqehcenkpv iigwnrnraa lsqkplnnnn
      121 eddegishvp kpygnndsak kmsdnnnglt evlkeiagld tapqirgnet nsretflgri
      181 ndcykrsler klppscmigg iketqgkhvi lsgstevisn eggrfcypef ssgeeseedv
      241 lfsnmeeehe swdesdeell ameirmrgqp rfanfrantl spvrffvdkk wntiplrnks
      301 lqricavdyd dsydeilngy eensvvsygq gsiqsmvssd stspdsslte esrsetassl
      361 sqkicnggls pgnpgdskdm keiepnyesp ssnnqdkdss qaskssikvp ethkavlalr
      421 leekdgkiav qtekeeskas tdvagqavti nlvpteeqak pyrvvnleqp lckpytvvdv
      481 saamasehle gpvnspktks ssstpnspvt sssltpgqis ahfqkssair yqevwtssts
      541 prqkipkvel itsgtgpnvp prknchksap tsptatniss ktipvkspnl seikfnsynn
      601 agmppfpiii hdeptyarss knaikvpivi npnaydnlai yksflgtsge lsvkekttsv
      661 ishtyeeiet eskvpdntts kttdclqtkg fsnstehkrg svaqkvqefn nclnrgqssp
      721 qrsyssshss pakiqratqe pvakiegtqe sqmvgssstr ekastvlsqi vasiqppqsp
      781 petpqsgpka csveelyaip pdadvakstp kstpvrpksl ftsqpsgeae apqttdsptt
      841 kvqkdpsikp vtpspsklvt spqseppapf ppprstsspy hagnllqrhf tnwtkptspt
      901 rsteaesvlh segsrraada kpkrwisfks ffrrrktdee ddkekerekg klvgldgtvi
      961 hmlppppvqr hhwfteakge ssekpaivfm yrcdpaqgql svdqskartd qaavmekgra
     1021 enallqdsek krshsspsqi pkkilshmth evtedfsprd prtvvgkqdg rgctsvttal
     1081 slpeleredg kedisdpmdp npcsatysnl gqsraamipp kqprqpkgav ddaiafggkt
     1141 dqeapnasqp tppplpkkmi irantepisk dlqksmessl cvmanptydi dpnwdassag
     1201 ssisyelkgl diesydsler plrkerpvps aansissltt lsikdrfsns meslssrrgp
     1261 scrqgrgiqk pqrqalyrgl enreevvgki rslhtdalkk lavkcedlfm agqkdqlrfg
     1321 vdswsdfrlt sdkpcceagd avyytasyak dplnnyavki ckskakesqq yyhslavrqs
     1381 lavhfniqqd cghflaevpn rllpwedpdd pekdeddmee teedakgetd gknpkpcsea
     1441 assqkenqgv mskkqrshvv vitrevpclt vadfvrdsla qhgkspdlye rqvcllllql
     1501 csglehlkpy hvthcdlrle nlllvhyqpg gtaqgfgpae psptssyptr livsnfsqak
     1561 qkshlvdpei lrdqsrlape iitatqykkc defqtgiliy emlhlpnpfd enpelkerey
     1621 tradlpripf rspysrglqq lascllnpnp serilisdak gilqcllwgp redlfqtfta
     1681 cpslvqrntl lqnwldikrt llmikfaeks ldreggisle dwlcaqylaf attdslsciv
     1741 kilqhr
//
LOCUS       XP_047289011            1746 aa            linear   PRI 05-AUG-2025
DEFINITION  inactive tyrosine-protein kinase PEAK1 isoform X1 [Homo sapiens].
ACCESSION   XP_047289011
VERSION     XP_047289011.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433055.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1746
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1746
                     /product="inactive tyrosine-protein kinase PEAK1 isoform
                     X1"
                     /calculated_mol_wt=192976
     Region          <1503..1668
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..1746
                     /gene="PEAK1"
                     /gene_synonym="SGK269"
                     /coded_by="XM_047433055.1:1032..6272"
                     /db_xref="GeneID:79834"
                     /db_xref="HGNC:HGNC:29431"
                     /db_xref="MIM:614248"
ORIGIN      
        1 msacntfteh vwkpgecknc fkpkslhqlp pdpekapith gnvktnanhs nnhrirntgn
       61 frppvakkpt iavkptmiva dgqsicgels iqehcenkpv iigwnrnraa lsqkplnnnn
      121 eddegishvp kpygnndsak kmsdnnnglt evlkeiagld tapqirgnet nsretflgri
      181 ndcykrsler klppscmigg iketqgkhvi lsgstevisn eggrfcypef ssgeeseedv
      241 lfsnmeeehe swdesdeell ameirmrgqp rfanfrantl spvrffvdkk wntiplrnks
      301 lqricavdyd dsydeilngy eensvvsygq gsiqsmvssd stspdsslte esrsetassl
      361 sqkicnggls pgnpgdskdm keiepnyesp ssnnqdkdss qaskssikvp ethkavlalr
      421 leekdgkiav qtekeeskas tdvagqavti nlvpteeqak pyrvvnleqp lckpytvvdv
      481 saamasehle gpvnspktks ssstpnspvt sssltpgqis ahfqkssair yqevwtssts
      541 prqkipkvel itsgtgpnvp prknchksap tsptatniss ktipvkspnl seikfnsynn
      601 agmppfpiii hdeptyarss knaikvpivi npnaydnlai yksflgtsge lsvkekttsv
      661 ishtyeeiet eskvpdntts kttdclqtkg fsnstehkrg svaqkvqefn nclnrgqssp
      721 qrsyssshss pakiqratqe pvakiegtqe sqmvgssstr ekastvlsqi vasiqppqsp
      781 petpqsgpka csveelyaip pdadvakstp kstpvrpksl ftsqpsgeae apqttdsptt
      841 kvqkdpsikp vtpspsklvt spqseppapf ppprstsspy hagnllqrhf tnwtkptspt
      901 rsteaesvlh segsrraada kpkrwisfks ffrrrktdee ddkekerekg klvgldgtvi
      961 hmlppppvqr hhwfteakge ssekpaivfm yrcdpaqgql svdqskartd qaavmekgra
     1021 enallqdsek krshsspsqi pkkilshmth evtedfsprd prtvvgkqdg rgctsvttal
     1081 slpeleredg kedisdpmdp npcsatysnl gqsraamipp kqprqpkgav ddaiafggkt
     1141 dqeapnasqp tppplpkkmi irantepisk dlqksmessl cvmanptydi dpnwdassag
     1201 ssisyelkgl diesydsler plrkerpvps aansissltt lsikdrfsns meslssrrgp
     1261 scrqgrgiqk pqrqalyrgl enreevvgki rslhtdalkk lavkcedlfm agqkdqlrfg
     1321 vdswsdfrlt sdkpcceagd avyytasyak dplnnyavki ckskakesqq yyhslavrqs
     1381 lavhfniqqd cghflaevpn rllpwedpdd pekdeddmee teedakgetd gknpkpcsea
     1441 assqkenqgv mskkqrshvv vitrevpclt vadfvrdsla qhgkspdlye rqvcllllql
     1501 csglehlkpy hvthcdlrle nlllvhyqpg gtaqgfgpae psptssyptr livsnfsqak
     1561 qkshlvdpei lrdqsrlape iitatqykkc defqtgiliy emlhlpnpfd enpelkerey
     1621 tradlpripf rspysrglqq lascllnpnp serilisdak gilqcllwgp redlfqtfta
     1681 cpslvqrntl lqnwldikrt llmikfaeks ldreggisle dwlcaqylaf attdslsciv
     1741 kilqhr
//
LOCUS       XP_047289012            1746 aa            linear   PRI 05-AUG-2025
DEFINITION  inactive tyrosine-protein kinase PEAK1 isoform X1 [Homo sapiens].
ACCESSION   XP_047289012
VERSION     XP_047289012.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433056.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1746
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1746
                     /product="inactive tyrosine-protein kinase PEAK1 isoform
                     X1"
                     /calculated_mol_wt=192976
     Region          <1503..1668
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..1746
                     /gene="PEAK1"
                     /gene_synonym="SGK269"
                     /coded_by="XM_047433056.1:2399..7639"
                     /db_xref="GeneID:79834"
                     /db_xref="HGNC:HGNC:29431"
                     /db_xref="MIM:614248"
ORIGIN      
        1 msacntfteh vwkpgecknc fkpkslhqlp pdpekapith gnvktnanhs nnhrirntgn
       61 frppvakkpt iavkptmiva dgqsicgels iqehcenkpv iigwnrnraa lsqkplnnnn
      121 eddegishvp kpygnndsak kmsdnnnglt evlkeiagld tapqirgnet nsretflgri
      181 ndcykrsler klppscmigg iketqgkhvi lsgstevisn eggrfcypef ssgeeseedv
      241 lfsnmeeehe swdesdeell ameirmrgqp rfanfrantl spvrffvdkk wntiplrnks
      301 lqricavdyd dsydeilngy eensvvsygq gsiqsmvssd stspdsslte esrsetassl
      361 sqkicnggls pgnpgdskdm keiepnyesp ssnnqdkdss qaskssikvp ethkavlalr
      421 leekdgkiav qtekeeskas tdvagqavti nlvpteeqak pyrvvnleqp lckpytvvdv
      481 saamasehle gpvnspktks ssstpnspvt sssltpgqis ahfqkssair yqevwtssts
      541 prqkipkvel itsgtgpnvp prknchksap tsptatniss ktipvkspnl seikfnsynn
      601 agmppfpiii hdeptyarss knaikvpivi npnaydnlai yksflgtsge lsvkekttsv
      661 ishtyeeiet eskvpdntts kttdclqtkg fsnstehkrg svaqkvqefn nclnrgqssp
      721 qrsyssshss pakiqratqe pvakiegtqe sqmvgssstr ekastvlsqi vasiqppqsp
      781 petpqsgpka csveelyaip pdadvakstp kstpvrpksl ftsqpsgeae apqttdsptt
      841 kvqkdpsikp vtpspsklvt spqseppapf ppprstsspy hagnllqrhf tnwtkptspt
      901 rsteaesvlh segsrraada kpkrwisfks ffrrrktdee ddkekerekg klvgldgtvi
      961 hmlppppvqr hhwfteakge ssekpaivfm yrcdpaqgql svdqskartd qaavmekgra
     1021 enallqdsek krshsspsqi pkkilshmth evtedfsprd prtvvgkqdg rgctsvttal
     1081 slpeleredg kedisdpmdp npcsatysnl gqsraamipp kqprqpkgav ddaiafggkt
     1141 dqeapnasqp tppplpkkmi irantepisk dlqksmessl cvmanptydi dpnwdassag
     1201 ssisyelkgl diesydsler plrkerpvps aansissltt lsikdrfsns meslssrrgp
     1261 scrqgrgiqk pqrqalyrgl enreevvgki rslhtdalkk lavkcedlfm agqkdqlrfg
     1321 vdswsdfrlt sdkpcceagd avyytasyak dplnnyavki ckskakesqq yyhslavrqs
     1381 lavhfniqqd cghflaevpn rllpwedpdd pekdeddmee teedakgetd gknpkpcsea
     1441 assqkenqgv mskkqrshvv vitrevpclt vadfvrdsla qhgkspdlye rqvcllllql
     1501 csglehlkpy hvthcdlrle nlllvhyqpg gtaqgfgpae psptssyptr livsnfsqak
     1561 qkshlvdpei lrdqsrlape iitatqykkc defqtgiliy emlhlpnpfd enpelkerey
     1621 tradlpripf rspysrglqq lascllnpnp serilisdak gilqcllwgp redlfqtfta
     1681 cpslvqrntl lqnwldikrt llmikfaeks ldreggisle dwlcaqylaf attdslsciv
     1741 kilqhr
//
LOCUS       XP_047289013            1746 aa            linear   PRI 05-AUG-2025
DEFINITION  inactive tyrosine-protein kinase PEAK1 isoform X1 [Homo sapiens].
ACCESSION   XP_047289013
VERSION     XP_047289013.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433057.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1746
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1746
                     /product="inactive tyrosine-protein kinase PEAK1 isoform
                     X1"
                     /calculated_mol_wt=192976
     Region          <1503..1668
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..1746
                     /gene="PEAK1"
                     /gene_synonym="SGK269"
                     /coded_by="XM_047433057.1:2539..7779"
                     /db_xref="GeneID:79834"
                     /db_xref="HGNC:HGNC:29431"
                     /db_xref="MIM:614248"
ORIGIN      
        1 msacntfteh vwkpgecknc fkpkslhqlp pdpekapith gnvktnanhs nnhrirntgn
       61 frppvakkpt iavkptmiva dgqsicgels iqehcenkpv iigwnrnraa lsqkplnnnn
      121 eddegishvp kpygnndsak kmsdnnnglt evlkeiagld tapqirgnet nsretflgri
      181 ndcykrsler klppscmigg iketqgkhvi lsgstevisn eggrfcypef ssgeeseedv
      241 lfsnmeeehe swdesdeell ameirmrgqp rfanfrantl spvrffvdkk wntiplrnks
      301 lqricavdyd dsydeilngy eensvvsygq gsiqsmvssd stspdsslte esrsetassl
      361 sqkicnggls pgnpgdskdm keiepnyesp ssnnqdkdss qaskssikvp ethkavlalr
      421 leekdgkiav qtekeeskas tdvagqavti nlvpteeqak pyrvvnleqp lckpytvvdv
      481 saamasehle gpvnspktks ssstpnspvt sssltpgqis ahfqkssair yqevwtssts
      541 prqkipkvel itsgtgpnvp prknchksap tsptatniss ktipvkspnl seikfnsynn
      601 agmppfpiii hdeptyarss knaikvpivi npnaydnlai yksflgtsge lsvkekttsv
      661 ishtyeeiet eskvpdntts kttdclqtkg fsnstehkrg svaqkvqefn nclnrgqssp
      721 qrsyssshss pakiqratqe pvakiegtqe sqmvgssstr ekastvlsqi vasiqppqsp
      781 petpqsgpka csveelyaip pdadvakstp kstpvrpksl ftsqpsgeae apqttdsptt
      841 kvqkdpsikp vtpspsklvt spqseppapf ppprstsspy hagnllqrhf tnwtkptspt
      901 rsteaesvlh segsrraada kpkrwisfks ffrrrktdee ddkekerekg klvgldgtvi
      961 hmlppppvqr hhwfteakge ssekpaivfm yrcdpaqgql svdqskartd qaavmekgra
     1021 enallqdsek krshsspsqi pkkilshmth evtedfsprd prtvvgkqdg rgctsvttal
     1081 slpeleredg kedisdpmdp npcsatysnl gqsraamipp kqprqpkgav ddaiafggkt
     1141 dqeapnasqp tppplpkkmi irantepisk dlqksmessl cvmanptydi dpnwdassag
     1201 ssisyelkgl diesydsler plrkerpvps aansissltt lsikdrfsns meslssrrgp
     1261 scrqgrgiqk pqrqalyrgl enreevvgki rslhtdalkk lavkcedlfm agqkdqlrfg
     1321 vdswsdfrlt sdkpcceagd avyytasyak dplnnyavki ckskakesqq yyhslavrqs
     1381 lavhfniqqd cghflaevpn rllpwedpdd pekdeddmee teedakgetd gknpkpcsea
     1441 assqkenqgv mskkqrshvv vitrevpclt vadfvrdsla qhgkspdlye rqvcllllql
     1501 csglehlkpy hvthcdlrle nlllvhyqpg gtaqgfgpae psptssyptr livsnfsqak
     1561 qkshlvdpei lrdqsrlape iitatqykkc defqtgiliy emlhlpnpfd enpelkerey
     1621 tradlpripf rspysrglqq lascllnpnp serilisdak gilqcllwgp redlfqtfta
     1681 cpslvqrntl lqnwldikrt llmikfaeks ldreggisle dwlcaqylaf attdslsciv
     1741 kilqhr
//
LOCUS       XP_047289014            1746 aa            linear   PRI 05-AUG-2025
DEFINITION  inactive tyrosine-protein kinase PEAK1 isoform X1 [Homo sapiens].
ACCESSION   XP_047289014
VERSION     XP_047289014.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433058.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1746
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1746
                     /product="inactive tyrosine-protein kinase PEAK1 isoform
                     X1"
                     /calculated_mol_wt=192976
     Region          <1503..1668
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..1746
                     /gene="PEAK1"
                     /gene_synonym="SGK269"
                     /coded_by="XM_047433058.1:2450..7690"
                     /db_xref="GeneID:79834"
                     /db_xref="HGNC:HGNC:29431"
                     /db_xref="MIM:614248"
ORIGIN      
        1 msacntfteh vwkpgecknc fkpkslhqlp pdpekapith gnvktnanhs nnhrirntgn
       61 frppvakkpt iavkptmiva dgqsicgels iqehcenkpv iigwnrnraa lsqkplnnnn
      121 eddegishvp kpygnndsak kmsdnnnglt evlkeiagld tapqirgnet nsretflgri
      181 ndcykrsler klppscmigg iketqgkhvi lsgstevisn eggrfcypef ssgeeseedv
      241 lfsnmeeehe swdesdeell ameirmrgqp rfanfrantl spvrffvdkk wntiplrnks
      301 lqricavdyd dsydeilngy eensvvsygq gsiqsmvssd stspdsslte esrsetassl
      361 sqkicnggls pgnpgdskdm keiepnyesp ssnnqdkdss qaskssikvp ethkavlalr
      421 leekdgkiav qtekeeskas tdvagqavti nlvpteeqak pyrvvnleqp lckpytvvdv
      481 saamasehle gpvnspktks ssstpnspvt sssltpgqis ahfqkssair yqevwtssts
      541 prqkipkvel itsgtgpnvp prknchksap tsptatniss ktipvkspnl seikfnsynn
      601 agmppfpiii hdeptyarss knaikvpivi npnaydnlai yksflgtsge lsvkekttsv
      661 ishtyeeiet eskvpdntts kttdclqtkg fsnstehkrg svaqkvqefn nclnrgqssp
      721 qrsyssshss pakiqratqe pvakiegtqe sqmvgssstr ekastvlsqi vasiqppqsp
      781 petpqsgpka csveelyaip pdadvakstp kstpvrpksl ftsqpsgeae apqttdsptt
      841 kvqkdpsikp vtpspsklvt spqseppapf ppprstsspy hagnllqrhf tnwtkptspt
      901 rsteaesvlh segsrraada kpkrwisfks ffrrrktdee ddkekerekg klvgldgtvi
      961 hmlppppvqr hhwfteakge ssekpaivfm yrcdpaqgql svdqskartd qaavmekgra
     1021 enallqdsek krshsspsqi pkkilshmth evtedfsprd prtvvgkqdg rgctsvttal
     1081 slpeleredg kedisdpmdp npcsatysnl gqsraamipp kqprqpkgav ddaiafggkt
     1141 dqeapnasqp tppplpkkmi irantepisk dlqksmessl cvmanptydi dpnwdassag
     1201 ssisyelkgl diesydsler plrkerpvps aansissltt lsikdrfsns meslssrrgp
     1261 scrqgrgiqk pqrqalyrgl enreevvgki rslhtdalkk lavkcedlfm agqkdqlrfg
     1321 vdswsdfrlt sdkpcceagd avyytasyak dplnnyavki ckskakesqq yyhslavrqs
     1381 lavhfniqqd cghflaevpn rllpwedpdd pekdeddmee teedakgetd gknpkpcsea
     1441 assqkenqgv mskkqrshvv vitrevpclt vadfvrdsla qhgkspdlye rqvcllllql
     1501 csglehlkpy hvthcdlrle nlllvhyqpg gtaqgfgpae psptssyptr livsnfsqak
     1561 qkshlvdpei lrdqsrlape iitatqykkc defqtgiliy emlhlpnpfd enpelkerey
     1621 tradlpripf rspysrglqq lascllnpnp serilisdak gilqcllwgp redlfqtfta
     1681 cpslvqrntl lqnwldikrt llmikfaeks ldreggisle dwlcaqylaf attdslsciv
     1741 kilqhr
//
LOCUS       XP_011520337            1746 aa            linear   PRI 05-AUG-2025
DEFINITION  inactive tyrosine-protein kinase PEAK1 isoform X1 [Homo sapiens].
ACCESSION   XP_011520337
VERSION     XP_011520337.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522035.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1746
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1746
                     /product="inactive tyrosine-protein kinase PEAK1 isoform
                     X1"
                     /calculated_mol_wt=192976
     Region          <1503..1668
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..1746
                     /gene="PEAK1"
                     /gene_synonym="SGK269"
                     /coded_by="XM_011522035.3:1206..6446"
                     /db_xref="GeneID:79834"
                     /db_xref="HGNC:HGNC:29431"
                     /db_xref="MIM:614248"
ORIGIN      
        1 msacntfteh vwkpgecknc fkpkslhqlp pdpekapith gnvktnanhs nnhrirntgn
       61 frppvakkpt iavkptmiva dgqsicgels iqehcenkpv iigwnrnraa lsqkplnnnn
      121 eddegishvp kpygnndsak kmsdnnnglt evlkeiagld tapqirgnet nsretflgri
      181 ndcykrsler klppscmigg iketqgkhvi lsgstevisn eggrfcypef ssgeeseedv
      241 lfsnmeeehe swdesdeell ameirmrgqp rfanfrantl spvrffvdkk wntiplrnks
      301 lqricavdyd dsydeilngy eensvvsygq gsiqsmvssd stspdsslte esrsetassl
      361 sqkicnggls pgnpgdskdm keiepnyesp ssnnqdkdss qaskssikvp ethkavlalr
      421 leekdgkiav qtekeeskas tdvagqavti nlvpteeqak pyrvvnleqp lckpytvvdv
      481 saamasehle gpvnspktks ssstpnspvt sssltpgqis ahfqkssair yqevwtssts
      541 prqkipkvel itsgtgpnvp prknchksap tsptatniss ktipvkspnl seikfnsynn
      601 agmppfpiii hdeptyarss knaikvpivi npnaydnlai yksflgtsge lsvkekttsv
      661 ishtyeeiet eskvpdntts kttdclqtkg fsnstehkrg svaqkvqefn nclnrgqssp
      721 qrsyssshss pakiqratqe pvakiegtqe sqmvgssstr ekastvlsqi vasiqppqsp
      781 petpqsgpka csveelyaip pdadvakstp kstpvrpksl ftsqpsgeae apqttdsptt
      841 kvqkdpsikp vtpspsklvt spqseppapf ppprstsspy hagnllqrhf tnwtkptspt
      901 rsteaesvlh segsrraada kpkrwisfks ffrrrktdee ddkekerekg klvgldgtvi
      961 hmlppppvqr hhwfteakge ssekpaivfm yrcdpaqgql svdqskartd qaavmekgra
     1021 enallqdsek krshsspsqi pkkilshmth evtedfsprd prtvvgkqdg rgctsvttal
     1081 slpeleredg kedisdpmdp npcsatysnl gqsraamipp kqprqpkgav ddaiafggkt
     1141 dqeapnasqp tppplpkkmi irantepisk dlqksmessl cvmanptydi dpnwdassag
     1201 ssisyelkgl diesydsler plrkerpvps aansissltt lsikdrfsns meslssrrgp
     1261 scrqgrgiqk pqrqalyrgl enreevvgki rslhtdalkk lavkcedlfm agqkdqlrfg
     1321 vdswsdfrlt sdkpcceagd avyytasyak dplnnyavki ckskakesqq yyhslavrqs
     1381 lavhfniqqd cghflaevpn rllpwedpdd pekdeddmee teedakgetd gknpkpcsea
     1441 assqkenqgv mskkqrshvv vitrevpclt vadfvrdsla qhgkspdlye rqvcllllql
     1501 csglehlkpy hvthcdlrle nlllvhyqpg gtaqgfgpae psptssyptr livsnfsqak
     1561 qkshlvdpei lrdqsrlape iitatqykkc defqtgiliy emlhlpnpfd enpelkerey
     1621 tradlpripf rspysrglqq lascllnpnp serilisdak gilqcllwgp redlfqtfta
     1681 cpslvqrntl lqnwldikrt llmikfaeks ldreggisle dwlcaqylaf attdslsciv
     1741 kilqhr
//
LOCUS       XP_011520339            1746 aa            linear   PRI 05-AUG-2025
DEFINITION  inactive tyrosine-protein kinase PEAK1 isoform X1 [Homo sapiens].
ACCESSION   XP_011520339
VERSION     XP_011520339.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522037.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1746
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1746
                     /product="inactive tyrosine-protein kinase PEAK1 isoform
                     X1"
                     /calculated_mol_wt=192976
     Region          <1503..1668
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..1746
                     /gene="PEAK1"
                     /gene_synonym="SGK269"
                     /coded_by="XM_011522037.3:1151..6391"
                     /db_xref="GeneID:79834"
                     /db_xref="HGNC:HGNC:29431"
                     /db_xref="MIM:614248"
ORIGIN      
        1 msacntfteh vwkpgecknc fkpkslhqlp pdpekapith gnvktnanhs nnhrirntgn
       61 frppvakkpt iavkptmiva dgqsicgels iqehcenkpv iigwnrnraa lsqkplnnnn
      121 eddegishvp kpygnndsak kmsdnnnglt evlkeiagld tapqirgnet nsretflgri
      181 ndcykrsler klppscmigg iketqgkhvi lsgstevisn eggrfcypef ssgeeseedv
      241 lfsnmeeehe swdesdeell ameirmrgqp rfanfrantl spvrffvdkk wntiplrnks
      301 lqricavdyd dsydeilngy eensvvsygq gsiqsmvssd stspdsslte esrsetassl
      361 sqkicnggls pgnpgdskdm keiepnyesp ssnnqdkdss qaskssikvp ethkavlalr
      421 leekdgkiav qtekeeskas tdvagqavti nlvpteeqak pyrvvnleqp lckpytvvdv
      481 saamasehle gpvnspktks ssstpnspvt sssltpgqis ahfqkssair yqevwtssts
      541 prqkipkvel itsgtgpnvp prknchksap tsptatniss ktipvkspnl seikfnsynn
      601 agmppfpiii hdeptyarss knaikvpivi npnaydnlai yksflgtsge lsvkekttsv
      661 ishtyeeiet eskvpdntts kttdclqtkg fsnstehkrg svaqkvqefn nclnrgqssp
      721 qrsyssshss pakiqratqe pvakiegtqe sqmvgssstr ekastvlsqi vasiqppqsp
      781 petpqsgpka csveelyaip pdadvakstp kstpvrpksl ftsqpsgeae apqttdsptt
      841 kvqkdpsikp vtpspsklvt spqseppapf ppprstsspy hagnllqrhf tnwtkptspt
      901 rsteaesvlh segsrraada kpkrwisfks ffrrrktdee ddkekerekg klvgldgtvi
      961 hmlppppvqr hhwfteakge ssekpaivfm yrcdpaqgql svdqskartd qaavmekgra
     1021 enallqdsek krshsspsqi pkkilshmth evtedfsprd prtvvgkqdg rgctsvttal
     1081 slpeleredg kedisdpmdp npcsatysnl gqsraamipp kqprqpkgav ddaiafggkt
     1141 dqeapnasqp tppplpkkmi irantepisk dlqksmessl cvmanptydi dpnwdassag
     1201 ssisyelkgl diesydsler plrkerpvps aansissltt lsikdrfsns meslssrrgp
     1261 scrqgrgiqk pqrqalyrgl enreevvgki rslhtdalkk lavkcedlfm agqkdqlrfg
     1321 vdswsdfrlt sdkpcceagd avyytasyak dplnnyavki ckskakesqq yyhslavrqs
     1381 lavhfniqqd cghflaevpn rllpwedpdd pekdeddmee teedakgetd gknpkpcsea
     1441 assqkenqgv mskkqrshvv vitrevpclt vadfvrdsla qhgkspdlye rqvcllllql
     1501 csglehlkpy hvthcdlrle nlllvhyqpg gtaqgfgpae psptssyptr livsnfsqak
     1561 qkshlvdpei lrdqsrlape iitatqykkc defqtgiliy emlhlpnpfd enpelkerey
     1621 tradlpripf rspysrglqq lascllnpnp serilisdak gilqcllwgp redlfqtfta
     1681 cpslvqrntl lqnwldikrt llmikfaeks ldreggisle dwlcaqylaf attdslsciv
     1741 kilqhr
//
LOCUS       XP_011520338            1746 aa            linear   PRI 05-AUG-2025
DEFINITION  inactive tyrosine-protein kinase PEAK1 isoform X1 [Homo sapiens].
ACCESSION   XP_011520338
VERSION     XP_011520338.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522036.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1746
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1746
                     /product="inactive tyrosine-protein kinase PEAK1 isoform
                     X1"
                     /calculated_mol_wt=192976
     Region          <1503..1668
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..1746
                     /gene="PEAK1"
                     /gene_synonym="SGK269"
                     /coded_by="XM_011522036.3:1110..6350"
                     /db_xref="GeneID:79834"
                     /db_xref="HGNC:HGNC:29431"
                     /db_xref="MIM:614248"
ORIGIN      
        1 msacntfteh vwkpgecknc fkpkslhqlp pdpekapith gnvktnanhs nnhrirntgn
       61 frppvakkpt iavkptmiva dgqsicgels iqehcenkpv iigwnrnraa lsqkplnnnn
      121 eddegishvp kpygnndsak kmsdnnnglt evlkeiagld tapqirgnet nsretflgri
      181 ndcykrsler klppscmigg iketqgkhvi lsgstevisn eggrfcypef ssgeeseedv
      241 lfsnmeeehe swdesdeell ameirmrgqp rfanfrantl spvrffvdkk wntiplrnks
      301 lqricavdyd dsydeilngy eensvvsygq gsiqsmvssd stspdsslte esrsetassl
      361 sqkicnggls pgnpgdskdm keiepnyesp ssnnqdkdss qaskssikvp ethkavlalr
      421 leekdgkiav qtekeeskas tdvagqavti nlvpteeqak pyrvvnleqp lckpytvvdv
      481 saamasehle gpvnspktks ssstpnspvt sssltpgqis ahfqkssair yqevwtssts
      541 prqkipkvel itsgtgpnvp prknchksap tsptatniss ktipvkspnl seikfnsynn
      601 agmppfpiii hdeptyarss knaikvpivi npnaydnlai yksflgtsge lsvkekttsv
      661 ishtyeeiet eskvpdntts kttdclqtkg fsnstehkrg svaqkvqefn nclnrgqssp
      721 qrsyssshss pakiqratqe pvakiegtqe sqmvgssstr ekastvlsqi vasiqppqsp
      781 petpqsgpka csveelyaip pdadvakstp kstpvrpksl ftsqpsgeae apqttdsptt
      841 kvqkdpsikp vtpspsklvt spqseppapf ppprstsspy hagnllqrhf tnwtkptspt
      901 rsteaesvlh segsrraada kpkrwisfks ffrrrktdee ddkekerekg klvgldgtvi
      961 hmlppppvqr hhwfteakge ssekpaivfm yrcdpaqgql svdqskartd qaavmekgra
     1021 enallqdsek krshsspsqi pkkilshmth evtedfsprd prtvvgkqdg rgctsvttal
     1081 slpeleredg kedisdpmdp npcsatysnl gqsraamipp kqprqpkgav ddaiafggkt
     1141 dqeapnasqp tppplpkkmi irantepisk dlqksmessl cvmanptydi dpnwdassag
     1201 ssisyelkgl diesydsler plrkerpvps aansissltt lsikdrfsns meslssrrgp
     1261 scrqgrgiqk pqrqalyrgl enreevvgki rslhtdalkk lavkcedlfm agqkdqlrfg
     1321 vdswsdfrlt sdkpcceagd avyytasyak dplnnyavki ckskakesqq yyhslavrqs
     1381 lavhfniqqd cghflaevpn rllpwedpdd pekdeddmee teedakgetd gknpkpcsea
     1441 assqkenqgv mskkqrshvv vitrevpclt vadfvrdsla qhgkspdlye rqvcllllql
     1501 csglehlkpy hvthcdlrle nlllvhyqpg gtaqgfgpae psptssyptr livsnfsqak
     1561 qkshlvdpei lrdqsrlape iitatqykkc defqtgiliy emlhlpnpfd enpelkerey
     1621 tradlpripf rspysrglqq lascllnpnp serilisdak gilqcllwgp redlfqtfta
     1681 cpslvqrntl lqnwldikrt llmikfaeks ldreggisle dwlcaqylaf attdslsciv
     1741 kilqhr
//
LOCUS       XP_047289016            1746 aa            linear   PRI 05-AUG-2025
DEFINITION  inactive tyrosine-protein kinase PEAK1 isoform X1 [Homo sapiens].
ACCESSION   XP_047289016
VERSION     XP_047289016.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433060.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1746
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1746
                     /product="inactive tyrosine-protein kinase PEAK1 isoform
                     X1"
                     /calculated_mol_wt=192976
     Region          <1503..1668
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..1746
                     /gene="PEAK1"
                     /gene_synonym="SGK269"
                     /coded_by="XM_047433060.1:1219..6459"
                     /db_xref="GeneID:79834"
                     /db_xref="HGNC:HGNC:29431"
                     /db_xref="MIM:614248"
ORIGIN      
        1 msacntfteh vwkpgecknc fkpkslhqlp pdpekapith gnvktnanhs nnhrirntgn
       61 frppvakkpt iavkptmiva dgqsicgels iqehcenkpv iigwnrnraa lsqkplnnnn
      121 eddegishvp kpygnndsak kmsdnnnglt evlkeiagld tapqirgnet nsretflgri
      181 ndcykrsler klppscmigg iketqgkhvi lsgstevisn eggrfcypef ssgeeseedv
      241 lfsnmeeehe swdesdeell ameirmrgqp rfanfrantl spvrffvdkk wntiplrnks
      301 lqricavdyd dsydeilngy eensvvsygq gsiqsmvssd stspdsslte esrsetassl
      361 sqkicnggls pgnpgdskdm keiepnyesp ssnnqdkdss qaskssikvp ethkavlalr
      421 leekdgkiav qtekeeskas tdvagqavti nlvpteeqak pyrvvnleqp lckpytvvdv
      481 saamasehle gpvnspktks ssstpnspvt sssltpgqis ahfqkssair yqevwtssts
      541 prqkipkvel itsgtgpnvp prknchksap tsptatniss ktipvkspnl seikfnsynn
      601 agmppfpiii hdeptyarss knaikvpivi npnaydnlai yksflgtsge lsvkekttsv
      661 ishtyeeiet eskvpdntts kttdclqtkg fsnstehkrg svaqkvqefn nclnrgqssp
      721 qrsyssshss pakiqratqe pvakiegtqe sqmvgssstr ekastvlsqi vasiqppqsp
      781 petpqsgpka csveelyaip pdadvakstp kstpvrpksl ftsqpsgeae apqttdsptt
      841 kvqkdpsikp vtpspsklvt spqseppapf ppprstsspy hagnllqrhf tnwtkptspt
      901 rsteaesvlh segsrraada kpkrwisfks ffrrrktdee ddkekerekg klvgldgtvi
      961 hmlppppvqr hhwfteakge ssekpaivfm yrcdpaqgql svdqskartd qaavmekgra
     1021 enallqdsek krshsspsqi pkkilshmth evtedfsprd prtvvgkqdg rgctsvttal
     1081 slpeleredg kedisdpmdp npcsatysnl gqsraamipp kqprqpkgav ddaiafggkt
     1141 dqeapnasqp tppplpkkmi irantepisk dlqksmessl cvmanptydi dpnwdassag
     1201 ssisyelkgl diesydsler plrkerpvps aansissltt lsikdrfsns meslssrrgp
     1261 scrqgrgiqk pqrqalyrgl enreevvgki rslhtdalkk lavkcedlfm agqkdqlrfg
     1321 vdswsdfrlt sdkpcceagd avyytasyak dplnnyavki ckskakesqq yyhslavrqs
     1381 lavhfniqqd cghflaevpn rllpwedpdd pekdeddmee teedakgetd gknpkpcsea
     1441 assqkenqgv mskkqrshvv vitrevpclt vadfvrdsla qhgkspdlye rqvcllllql
     1501 csglehlkpy hvthcdlrle nlllvhyqpg gtaqgfgpae psptssyptr livsnfsqak
     1561 qkshlvdpei lrdqsrlape iitatqykkc defqtgiliy emlhlpnpfd enpelkerey
     1621 tradlpripf rspysrglqq lascllnpnp serilisdak gilqcllwgp redlfqtfta
     1681 cpslvqrntl lqnwldikrt llmikfaeks ldreggisle dwlcaqylaf attdslsciv
     1741 kilqhr
//
LOCUS       XP_011520341            1746 aa            linear   PRI 05-AUG-2025
DEFINITION  inactive tyrosine-protein kinase PEAK1 isoform X1 [Homo sapiens].
ACCESSION   XP_011520341
VERSION     XP_011520341.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522039.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1746
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1746
                     /product="inactive tyrosine-protein kinase PEAK1 isoform
                     X1"
                     /calculated_mol_wt=192976
     Region          <1503..1668
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..1746
                     /gene="PEAK1"
                     /gene_synonym="SGK269"
                     /coded_by="XM_011522039.3:1098..6338"
                     /db_xref="GeneID:79834"
                     /db_xref="HGNC:HGNC:29431"
                     /db_xref="MIM:614248"
ORIGIN      
        1 msacntfteh vwkpgecknc fkpkslhqlp pdpekapith gnvktnanhs nnhrirntgn
       61 frppvakkpt iavkptmiva dgqsicgels iqehcenkpv iigwnrnraa lsqkplnnnn
      121 eddegishvp kpygnndsak kmsdnnnglt evlkeiagld tapqirgnet nsretflgri
      181 ndcykrsler klppscmigg iketqgkhvi lsgstevisn eggrfcypef ssgeeseedv
      241 lfsnmeeehe swdesdeell ameirmrgqp rfanfrantl spvrffvdkk wntiplrnks
      301 lqricavdyd dsydeilngy eensvvsygq gsiqsmvssd stspdsslte esrsetassl
      361 sqkicnggls pgnpgdskdm keiepnyesp ssnnqdkdss qaskssikvp ethkavlalr
      421 leekdgkiav qtekeeskas tdvagqavti nlvpteeqak pyrvvnleqp lckpytvvdv
      481 saamasehle gpvnspktks ssstpnspvt sssltpgqis ahfqkssair yqevwtssts
      541 prqkipkvel itsgtgpnvp prknchksap tsptatniss ktipvkspnl seikfnsynn
      601 agmppfpiii hdeptyarss knaikvpivi npnaydnlai yksflgtsge lsvkekttsv
      661 ishtyeeiet eskvpdntts kttdclqtkg fsnstehkrg svaqkvqefn nclnrgqssp
      721 qrsyssshss pakiqratqe pvakiegtqe sqmvgssstr ekastvlsqi vasiqppqsp
      781 petpqsgpka csveelyaip pdadvakstp kstpvrpksl ftsqpsgeae apqttdsptt
      841 kvqkdpsikp vtpspsklvt spqseppapf ppprstsspy hagnllqrhf tnwtkptspt
      901 rsteaesvlh segsrraada kpkrwisfks ffrrrktdee ddkekerekg klvgldgtvi
      961 hmlppppvqr hhwfteakge ssekpaivfm yrcdpaqgql svdqskartd qaavmekgra
     1021 enallqdsek krshsspsqi pkkilshmth evtedfsprd prtvvgkqdg rgctsvttal
     1081 slpeleredg kedisdpmdp npcsatysnl gqsraamipp kqprqpkgav ddaiafggkt
     1141 dqeapnasqp tppplpkkmi irantepisk dlqksmessl cvmanptydi dpnwdassag
     1201 ssisyelkgl diesydsler plrkerpvps aansissltt lsikdrfsns meslssrrgp
     1261 scrqgrgiqk pqrqalyrgl enreevvgki rslhtdalkk lavkcedlfm agqkdqlrfg
     1321 vdswsdfrlt sdkpcceagd avyytasyak dplnnyavki ckskakesqq yyhslavrqs
     1381 lavhfniqqd cghflaevpn rllpwedpdd pekdeddmee teedakgetd gknpkpcsea
     1441 assqkenqgv mskkqrshvv vitrevpclt vadfvrdsla qhgkspdlye rqvcllllql
     1501 csglehlkpy hvthcdlrle nlllvhyqpg gtaqgfgpae psptssyptr livsnfsqak
     1561 qkshlvdpei lrdqsrlape iitatqykkc defqtgiliy emlhlpnpfd enpelkerey
     1621 tradlpripf rspysrglqq lascllnpnp serilisdak gilqcllwgp redlfqtfta
     1681 cpslvqrntl lqnwldikrt llmikfaeks ldreggisle dwlcaqylaf attdslsciv
     1741 kilqhr
//
LOCUS       XP_011520340            1746 aa            linear   PRI 05-AUG-2025
DEFINITION  inactive tyrosine-protein kinase PEAK1 isoform X1 [Homo sapiens].
ACCESSION   XP_011520340
VERSION     XP_011520340.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522038.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1746
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1746
                     /product="inactive tyrosine-protein kinase PEAK1 isoform
                     X1"
                     /calculated_mol_wt=192976
     Region          <1503..1668
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..1746
                     /gene="PEAK1"
                     /gene_synonym="SGK269"
                     /coded_by="XM_011522038.3:1002..6242"
                     /db_xref="GeneID:79834"
                     /db_xref="HGNC:HGNC:29431"
                     /db_xref="MIM:614248"
ORIGIN      
        1 msacntfteh vwkpgecknc fkpkslhqlp pdpekapith gnvktnanhs nnhrirntgn
       61 frppvakkpt iavkptmiva dgqsicgels iqehcenkpv iigwnrnraa lsqkplnnnn
      121 eddegishvp kpygnndsak kmsdnnnglt evlkeiagld tapqirgnet nsretflgri
      181 ndcykrsler klppscmigg iketqgkhvi lsgstevisn eggrfcypef ssgeeseedv
      241 lfsnmeeehe swdesdeell ameirmrgqp rfanfrantl spvrffvdkk wntiplrnks
      301 lqricavdyd dsydeilngy eensvvsygq gsiqsmvssd stspdsslte esrsetassl
      361 sqkicnggls pgnpgdskdm keiepnyesp ssnnqdkdss qaskssikvp ethkavlalr
      421 leekdgkiav qtekeeskas tdvagqavti nlvpteeqak pyrvvnleqp lckpytvvdv
      481 saamasehle gpvnspktks ssstpnspvt sssltpgqis ahfqkssair yqevwtssts
      541 prqkipkvel itsgtgpnvp prknchksap tsptatniss ktipvkspnl seikfnsynn
      601 agmppfpiii hdeptyarss knaikvpivi npnaydnlai yksflgtsge lsvkekttsv
      661 ishtyeeiet eskvpdntts kttdclqtkg fsnstehkrg svaqkvqefn nclnrgqssp
      721 qrsyssshss pakiqratqe pvakiegtqe sqmvgssstr ekastvlsqi vasiqppqsp
      781 petpqsgpka csveelyaip pdadvakstp kstpvrpksl ftsqpsgeae apqttdsptt
      841 kvqkdpsikp vtpspsklvt spqseppapf ppprstsspy hagnllqrhf tnwtkptspt
      901 rsteaesvlh segsrraada kpkrwisfks ffrrrktdee ddkekerekg klvgldgtvi
      961 hmlppppvqr hhwfteakge ssekpaivfm yrcdpaqgql svdqskartd qaavmekgra
     1021 enallqdsek krshsspsqi pkkilshmth evtedfsprd prtvvgkqdg rgctsvttal
     1081 slpeleredg kedisdpmdp npcsatysnl gqsraamipp kqprqpkgav ddaiafggkt
     1141 dqeapnasqp tppplpkkmi irantepisk dlqksmessl cvmanptydi dpnwdassag
     1201 ssisyelkgl diesydsler plrkerpvps aansissltt lsikdrfsns meslssrrgp
     1261 scrqgrgiqk pqrqalyrgl enreevvgki rslhtdalkk lavkcedlfm agqkdqlrfg
     1321 vdswsdfrlt sdkpcceagd avyytasyak dplnnyavki ckskakesqq yyhslavrqs
     1381 lavhfniqqd cghflaevpn rllpwedpdd pekdeddmee teedakgetd gknpkpcsea
     1441 assqkenqgv mskkqrshvv vitrevpclt vadfvrdsla qhgkspdlye rqvcllllql
     1501 csglehlkpy hvthcdlrle nlllvhyqpg gtaqgfgpae psptssyptr livsnfsqak
     1561 qkshlvdpei lrdqsrlape iitatqykkc defqtgiliy emlhlpnpfd enpelkerey
     1621 tradlpripf rspysrglqq lascllnpnp serilisdak gilqcllwgp redlfqtfta
     1681 cpslvqrntl lqnwldikrt llmikfaeks ldreggisle dwlcaqylaf attdslsciv
     1741 kilqhr
//
LOCUS       XP_047289017            1746 aa            linear   PRI 05-AUG-2025
DEFINITION  inactive tyrosine-protein kinase PEAK1 isoform X1 [Homo sapiens].
ACCESSION   XP_047289017
VERSION     XP_047289017.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433061.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1746
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1746
                     /product="inactive tyrosine-protein kinase PEAK1 isoform
                     X1"
                     /calculated_mol_wt=192976
     Region          <1503..1668
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..1746
                     /gene="PEAK1"
                     /gene_synonym="SGK269"
                     /coded_by="XM_047433061.1:952..6192"
                     /db_xref="GeneID:79834"
                     /db_xref="HGNC:HGNC:29431"
                     /db_xref="MIM:614248"
ORIGIN      
        1 msacntfteh vwkpgecknc fkpkslhqlp pdpekapith gnvktnanhs nnhrirntgn
       61 frppvakkpt iavkptmiva dgqsicgels iqehcenkpv iigwnrnraa lsqkplnnnn
      121 eddegishvp kpygnndsak kmsdnnnglt evlkeiagld tapqirgnet nsretflgri
      181 ndcykrsler klppscmigg iketqgkhvi lsgstevisn eggrfcypef ssgeeseedv
      241 lfsnmeeehe swdesdeell ameirmrgqp rfanfrantl spvrffvdkk wntiplrnks
      301 lqricavdyd dsydeilngy eensvvsygq gsiqsmvssd stspdsslte esrsetassl
      361 sqkicnggls pgnpgdskdm keiepnyesp ssnnqdkdss qaskssikvp ethkavlalr
      421 leekdgkiav qtekeeskas tdvagqavti nlvpteeqak pyrvvnleqp lckpytvvdv
      481 saamasehle gpvnspktks ssstpnspvt sssltpgqis ahfqkssair yqevwtssts
      541 prqkipkvel itsgtgpnvp prknchksap tsptatniss ktipvkspnl seikfnsynn
      601 agmppfpiii hdeptyarss knaikvpivi npnaydnlai yksflgtsge lsvkekttsv
      661 ishtyeeiet eskvpdntts kttdclqtkg fsnstehkrg svaqkvqefn nclnrgqssp
      721 qrsyssshss pakiqratqe pvakiegtqe sqmvgssstr ekastvlsqi vasiqppqsp
      781 petpqsgpka csveelyaip pdadvakstp kstpvrpksl ftsqpsgeae apqttdsptt
      841 kvqkdpsikp vtpspsklvt spqseppapf ppprstsspy hagnllqrhf tnwtkptspt
      901 rsteaesvlh segsrraada kpkrwisfks ffrrrktdee ddkekerekg klvgldgtvi
      961 hmlppppvqr hhwfteakge ssekpaivfm yrcdpaqgql svdqskartd qaavmekgra
     1021 enallqdsek krshsspsqi pkkilshmth evtedfsprd prtvvgkqdg rgctsvttal
     1081 slpeleredg kedisdpmdp npcsatysnl gqsraamipp kqprqpkgav ddaiafggkt
     1141 dqeapnasqp tppplpkkmi irantepisk dlqksmessl cvmanptydi dpnwdassag
     1201 ssisyelkgl diesydsler plrkerpvps aansissltt lsikdrfsns meslssrrgp
     1261 scrqgrgiqk pqrqalyrgl enreevvgki rslhtdalkk lavkcedlfm agqkdqlrfg
     1321 vdswsdfrlt sdkpcceagd avyytasyak dplnnyavki ckskakesqq yyhslavrqs
     1381 lavhfniqqd cghflaevpn rllpwedpdd pekdeddmee teedakgetd gknpkpcsea
     1441 assqkenqgv mskkqrshvv vitrevpclt vadfvrdsla qhgkspdlye rqvcllllql
     1501 csglehlkpy hvthcdlrle nlllvhyqpg gtaqgfgpae psptssyptr livsnfsqak
     1561 qkshlvdpei lrdqsrlape iitatqykkc defqtgiliy emlhlpnpfd enpelkerey
     1621 tradlpripf rspysrglqq lascllnpnp serilisdak gilqcllwgp redlfqtfta
     1681 cpslvqrntl lqnwldikrt llmikfaeks ldreggisle dwlcaqylaf attdslsciv
     1741 kilqhr
//
LOCUS       XP_047289018            1746 aa            linear   PRI 05-AUG-2025
DEFINITION  inactive tyrosine-protein kinase PEAK1 isoform X1 [Homo sapiens].
ACCESSION   XP_047289018
VERSION     XP_047289018.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433062.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1746
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1746
                     /product="inactive tyrosine-protein kinase PEAK1 isoform
                     X1"
                     /calculated_mol_wt=192976
     Region          <1503..1668
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..1746
                     /gene="PEAK1"
                     /gene_synonym="SGK269"
                     /coded_by="XM_047433062.1:5209..10449"
                     /db_xref="GeneID:79834"
                     /db_xref="HGNC:HGNC:29431"
                     /db_xref="MIM:614248"
ORIGIN      
        1 msacntfteh vwkpgecknc fkpkslhqlp pdpekapith gnvktnanhs nnhrirntgn
       61 frppvakkpt iavkptmiva dgqsicgels iqehcenkpv iigwnrnraa lsqkplnnnn
      121 eddegishvp kpygnndsak kmsdnnnglt evlkeiagld tapqirgnet nsretflgri
      181 ndcykrsler klppscmigg iketqgkhvi lsgstevisn eggrfcypef ssgeeseedv
      241 lfsnmeeehe swdesdeell ameirmrgqp rfanfrantl spvrffvdkk wntiplrnks
      301 lqricavdyd dsydeilngy eensvvsygq gsiqsmvssd stspdsslte esrsetassl
      361 sqkicnggls pgnpgdskdm keiepnyesp ssnnqdkdss qaskssikvp ethkavlalr
      421 leekdgkiav qtekeeskas tdvagqavti nlvpteeqak pyrvvnleqp lckpytvvdv
      481 saamasehle gpvnspktks ssstpnspvt sssltpgqis ahfqkssair yqevwtssts
      541 prqkipkvel itsgtgpnvp prknchksap tsptatniss ktipvkspnl seikfnsynn
      601 agmppfpiii hdeptyarss knaikvpivi npnaydnlai yksflgtsge lsvkekttsv
      661 ishtyeeiet eskvpdntts kttdclqtkg fsnstehkrg svaqkvqefn nclnrgqssp
      721 qrsyssshss pakiqratqe pvakiegtqe sqmvgssstr ekastvlsqi vasiqppqsp
      781 petpqsgpka csveelyaip pdadvakstp kstpvrpksl ftsqpsgeae apqttdsptt
      841 kvqkdpsikp vtpspsklvt spqseppapf ppprstsspy hagnllqrhf tnwtkptspt
      901 rsteaesvlh segsrraada kpkrwisfks ffrrrktdee ddkekerekg klvgldgtvi
      961 hmlppppvqr hhwfteakge ssekpaivfm yrcdpaqgql svdqskartd qaavmekgra
     1021 enallqdsek krshsspsqi pkkilshmth evtedfsprd prtvvgkqdg rgctsvttal
     1081 slpeleredg kedisdpmdp npcsatysnl gqsraamipp kqprqpkgav ddaiafggkt
     1141 dqeapnasqp tppplpkkmi irantepisk dlqksmessl cvmanptydi dpnwdassag
     1201 ssisyelkgl diesydsler plrkerpvps aansissltt lsikdrfsns meslssrrgp
     1261 scrqgrgiqk pqrqalyrgl enreevvgki rslhtdalkk lavkcedlfm agqkdqlrfg
     1321 vdswsdfrlt sdkpcceagd avyytasyak dplnnyavki ckskakesqq yyhslavrqs
     1381 lavhfniqqd cghflaevpn rllpwedpdd pekdeddmee teedakgetd gknpkpcsea
     1441 assqkenqgv mskkqrshvv vitrevpclt vadfvrdsla qhgkspdlye rqvcllllql
     1501 csglehlkpy hvthcdlrle nlllvhyqpg gtaqgfgpae psptssyptr livsnfsqak
     1561 qkshlvdpei lrdqsrlape iitatqykkc defqtgiliy emlhlpnpfd enpelkerey
     1621 tradlpripf rspysrglqq lascllnpnp serilisdak gilqcllwgp redlfqtfta
     1681 cpslvqrntl lqnwldikrt llmikfaeks ldreggisle dwlcaqylaf attdslsciv
     1741 kilqhr
//
LOCUS       XP_047289019            1746 aa            linear   PRI 05-AUG-2025
DEFINITION  inactive tyrosine-protein kinase PEAK1 isoform X1 [Homo sapiens].
ACCESSION   XP_047289019
VERSION     XP_047289019.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433063.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1746
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1746
                     /product="inactive tyrosine-protein kinase PEAK1 isoform
                     X1"
                     /calculated_mol_wt=192976
     Region          <1503..1668
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..1746
                     /gene="PEAK1"
                     /gene_synonym="SGK269"
                     /coded_by="XM_047433063.1:627..5867"
                     /db_xref="GeneID:79834"
                     /db_xref="HGNC:HGNC:29431"
                     /db_xref="MIM:614248"
ORIGIN      
        1 msacntfteh vwkpgecknc fkpkslhqlp pdpekapith gnvktnanhs nnhrirntgn
       61 frppvakkpt iavkptmiva dgqsicgels iqehcenkpv iigwnrnraa lsqkplnnnn
      121 eddegishvp kpygnndsak kmsdnnnglt evlkeiagld tapqirgnet nsretflgri
      181 ndcykrsler klppscmigg iketqgkhvi lsgstevisn eggrfcypef ssgeeseedv
      241 lfsnmeeehe swdesdeell ameirmrgqp rfanfrantl spvrffvdkk wntiplrnks
      301 lqricavdyd dsydeilngy eensvvsygq gsiqsmvssd stspdsslte esrsetassl
      361 sqkicnggls pgnpgdskdm keiepnyesp ssnnqdkdss qaskssikvp ethkavlalr
      421 leekdgkiav qtekeeskas tdvagqavti nlvpteeqak pyrvvnleqp lckpytvvdv
      481 saamasehle gpvnspktks ssstpnspvt sssltpgqis ahfqkssair yqevwtssts
      541 prqkipkvel itsgtgpnvp prknchksap tsptatniss ktipvkspnl seikfnsynn
      601 agmppfpiii hdeptyarss knaikvpivi npnaydnlai yksflgtsge lsvkekttsv
      661 ishtyeeiet eskvpdntts kttdclqtkg fsnstehkrg svaqkvqefn nclnrgqssp
      721 qrsyssshss pakiqratqe pvakiegtqe sqmvgssstr ekastvlsqi vasiqppqsp
      781 petpqsgpka csveelyaip pdadvakstp kstpvrpksl ftsqpsgeae apqttdsptt
      841 kvqkdpsikp vtpspsklvt spqseppapf ppprstsspy hagnllqrhf tnwtkptspt
      901 rsteaesvlh segsrraada kpkrwisfks ffrrrktdee ddkekerekg klvgldgtvi
      961 hmlppppvqr hhwfteakge ssekpaivfm yrcdpaqgql svdqskartd qaavmekgra
     1021 enallqdsek krshsspsqi pkkilshmth evtedfsprd prtvvgkqdg rgctsvttal
     1081 slpeleredg kedisdpmdp npcsatysnl gqsraamipp kqprqpkgav ddaiafggkt
     1141 dqeapnasqp tppplpkkmi irantepisk dlqksmessl cvmanptydi dpnwdassag
     1201 ssisyelkgl diesydsler plrkerpvps aansissltt lsikdrfsns meslssrrgp
     1261 scrqgrgiqk pqrqalyrgl enreevvgki rslhtdalkk lavkcedlfm agqkdqlrfg
     1321 vdswsdfrlt sdkpcceagd avyytasyak dplnnyavki ckskakesqq yyhslavrqs
     1381 lavhfniqqd cghflaevpn rllpwedpdd pekdeddmee teedakgetd gknpkpcsea
     1441 assqkenqgv mskkqrshvv vitrevpclt vadfvrdsla qhgkspdlye rqvcllllql
     1501 csglehlkpy hvthcdlrle nlllvhyqpg gtaqgfgpae psptssyptr livsnfsqak
     1561 qkshlvdpei lrdqsrlape iitatqykkc defqtgiliy emlhlpnpfd enpelkerey
     1621 tradlpripf rspysrglqq lascllnpnp serilisdak gilqcllwgp redlfqtfta
     1681 cpslvqrntl lqnwldikrt llmikfaeks ldreggisle dwlcaqylaf attdslsciv
     1741 kilqhr
//
LOCUS       XP_047289020            1746 aa            linear   PRI 05-AUG-2025
DEFINITION  inactive tyrosine-protein kinase PEAK1 isoform X1 [Homo sapiens].
ACCESSION   XP_047289020
VERSION     XP_047289020.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433064.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1746
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1746
                     /product="inactive tyrosine-protein kinase PEAK1 isoform
                     X1"
                     /calculated_mol_wt=192976
     Region          <1503..1668
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..1746
                     /gene="PEAK1"
                     /gene_synonym="SGK269"
                     /coded_by="XM_047433064.1:2469..7709"
                     /db_xref="GeneID:79834"
                     /db_xref="HGNC:HGNC:29431"
                     /db_xref="MIM:614248"
ORIGIN      
        1 msacntfteh vwkpgecknc fkpkslhqlp pdpekapith gnvktnanhs nnhrirntgn
       61 frppvakkpt iavkptmiva dgqsicgels iqehcenkpv iigwnrnraa lsqkplnnnn
      121 eddegishvp kpygnndsak kmsdnnnglt evlkeiagld tapqirgnet nsretflgri
      181 ndcykrsler klppscmigg iketqgkhvi lsgstevisn eggrfcypef ssgeeseedv
      241 lfsnmeeehe swdesdeell ameirmrgqp rfanfrantl spvrffvdkk wntiplrnks
      301 lqricavdyd dsydeilngy eensvvsygq gsiqsmvssd stspdsslte esrsetassl
      361 sqkicnggls pgnpgdskdm keiepnyesp ssnnqdkdss qaskssikvp ethkavlalr
      421 leekdgkiav qtekeeskas tdvagqavti nlvpteeqak pyrvvnleqp lckpytvvdv
      481 saamasehle gpvnspktks ssstpnspvt sssltpgqis ahfqkssair yqevwtssts
      541 prqkipkvel itsgtgpnvp prknchksap tsptatniss ktipvkspnl seikfnsynn
      601 agmppfpiii hdeptyarss knaikvpivi npnaydnlai yksflgtsge lsvkekttsv
      661 ishtyeeiet eskvpdntts kttdclqtkg fsnstehkrg svaqkvqefn nclnrgqssp
      721 qrsyssshss pakiqratqe pvakiegtqe sqmvgssstr ekastvlsqi vasiqppqsp
      781 petpqsgpka csveelyaip pdadvakstp kstpvrpksl ftsqpsgeae apqttdsptt
      841 kvqkdpsikp vtpspsklvt spqseppapf ppprstsspy hagnllqrhf tnwtkptspt
      901 rsteaesvlh segsrraada kpkrwisfks ffrrrktdee ddkekerekg klvgldgtvi
      961 hmlppppvqr hhwfteakge ssekpaivfm yrcdpaqgql svdqskartd qaavmekgra
     1021 enallqdsek krshsspsqi pkkilshmth evtedfsprd prtvvgkqdg rgctsvttal
     1081 slpeleredg kedisdpmdp npcsatysnl gqsraamipp kqprqpkgav ddaiafggkt
     1141 dqeapnasqp tppplpkkmi irantepisk dlqksmessl cvmanptydi dpnwdassag
     1201 ssisyelkgl diesydsler plrkerpvps aansissltt lsikdrfsns meslssrrgp
     1261 scrqgrgiqk pqrqalyrgl enreevvgki rslhtdalkk lavkcedlfm agqkdqlrfg
     1321 vdswsdfrlt sdkpcceagd avyytasyak dplnnyavki ckskakesqq yyhslavrqs
     1381 lavhfniqqd cghflaevpn rllpwedpdd pekdeddmee teedakgetd gknpkpcsea
     1441 assqkenqgv mskkqrshvv vitrevpclt vadfvrdsla qhgkspdlye rqvcllllql
     1501 csglehlkpy hvthcdlrle nlllvhyqpg gtaqgfgpae psptssyptr livsnfsqak
     1561 qkshlvdpei lrdqsrlape iitatqykkc defqtgiliy emlhlpnpfd enpelkerey
     1621 tradlpripf rspysrglqq lascllnpnp serilisdak gilqcllwgp redlfqtfta
     1681 cpslvqrntl lqnwldikrt llmikfaeks ldreggisle dwlcaqylaf attdslsciv
     1741 kilqhr
//
LOCUS       XP_047289021            1746 aa            linear   PRI 05-AUG-2025
DEFINITION  inactive tyrosine-protein kinase PEAK1 isoform X1 [Homo sapiens].
ACCESSION   XP_047289021
VERSION     XP_047289021.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433065.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1746
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1746
                     /product="inactive tyrosine-protein kinase PEAK1 isoform
                     X1"
                     /calculated_mol_wt=192976
     Region          <1503..1668
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..1746
                     /gene="PEAK1"
                     /gene_synonym="SGK269"
                     /coded_by="XM_047433065.1:833..6073"
                     /db_xref="GeneID:79834"
                     /db_xref="HGNC:HGNC:29431"
                     /db_xref="MIM:614248"
ORIGIN      
        1 msacntfteh vwkpgecknc fkpkslhqlp pdpekapith gnvktnanhs nnhrirntgn
       61 frppvakkpt iavkptmiva dgqsicgels iqehcenkpv iigwnrnraa lsqkplnnnn
      121 eddegishvp kpygnndsak kmsdnnnglt evlkeiagld tapqirgnet nsretflgri
      181 ndcykrsler klppscmigg iketqgkhvi lsgstevisn eggrfcypef ssgeeseedv
      241 lfsnmeeehe swdesdeell ameirmrgqp rfanfrantl spvrffvdkk wntiplrnks
      301 lqricavdyd dsydeilngy eensvvsygq gsiqsmvssd stspdsslte esrsetassl
      361 sqkicnggls pgnpgdskdm keiepnyesp ssnnqdkdss qaskssikvp ethkavlalr
      421 leekdgkiav qtekeeskas tdvagqavti nlvpteeqak pyrvvnleqp lckpytvvdv
      481 saamasehle gpvnspktks ssstpnspvt sssltpgqis ahfqkssair yqevwtssts
      541 prqkipkvel itsgtgpnvp prknchksap tsptatniss ktipvkspnl seikfnsynn
      601 agmppfpiii hdeptyarss knaikvpivi npnaydnlai yksflgtsge lsvkekttsv
      661 ishtyeeiet eskvpdntts kttdclqtkg fsnstehkrg svaqkvqefn nclnrgqssp
      721 qrsyssshss pakiqratqe pvakiegtqe sqmvgssstr ekastvlsqi vasiqppqsp
      781 petpqsgpka csveelyaip pdadvakstp kstpvrpksl ftsqpsgeae apqttdsptt
      841 kvqkdpsikp vtpspsklvt spqseppapf ppprstsspy hagnllqrhf tnwtkptspt
      901 rsteaesvlh segsrraada kpkrwisfks ffrrrktdee ddkekerekg klvgldgtvi
      961 hmlppppvqr hhwfteakge ssekpaivfm yrcdpaqgql svdqskartd qaavmekgra
     1021 enallqdsek krshsspsqi pkkilshmth evtedfsprd prtvvgkqdg rgctsvttal
     1081 slpeleredg kedisdpmdp npcsatysnl gqsraamipp kqprqpkgav ddaiafggkt
     1141 dqeapnasqp tppplpkkmi irantepisk dlqksmessl cvmanptydi dpnwdassag
     1201 ssisyelkgl diesydsler plrkerpvps aansissltt lsikdrfsns meslssrrgp
     1261 scrqgrgiqk pqrqalyrgl enreevvgki rslhtdalkk lavkcedlfm agqkdqlrfg
     1321 vdswsdfrlt sdkpcceagd avyytasyak dplnnyavki ckskakesqq yyhslavrqs
     1381 lavhfniqqd cghflaevpn rllpwedpdd pekdeddmee teedakgetd gknpkpcsea
     1441 assqkenqgv mskkqrshvv vitrevpclt vadfvrdsla qhgkspdlye rqvcllllql
     1501 csglehlkpy hvthcdlrle nlllvhyqpg gtaqgfgpae psptssyptr livsnfsqak
     1561 qkshlvdpei lrdqsrlape iitatqykkc defqtgiliy emlhlpnpfd enpelkerey
     1621 tradlpripf rspysrglqq lascllnpnp serilisdak gilqcllwgp redlfqtfta
     1681 cpslvqrntl lqnwldikrt llmikfaeks ldreggisle dwlcaqylaf attdslsciv
     1741 kilqhr
//
LOCUS       XP_047289023            1746 aa            linear   PRI 05-AUG-2025
DEFINITION  inactive tyrosine-protein kinase PEAK1 isoform X1 [Homo sapiens].
ACCESSION   XP_047289023
VERSION     XP_047289023.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433067.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1746
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1746
                     /product="inactive tyrosine-protein kinase PEAK1 isoform
                     X1"
                     /calculated_mol_wt=192976
     Region          <1503..1668
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..1746
                     /gene="PEAK1"
                     /gene_synonym="SGK269"
                     /coded_by="XM_047433067.1:786..6026"
                     /db_xref="GeneID:79834"
                     /db_xref="HGNC:HGNC:29431"
                     /db_xref="MIM:614248"
ORIGIN      
        1 msacntfteh vwkpgecknc fkpkslhqlp pdpekapith gnvktnanhs nnhrirntgn
       61 frppvakkpt iavkptmiva dgqsicgels iqehcenkpv iigwnrnraa lsqkplnnnn
      121 eddegishvp kpygnndsak kmsdnnnglt evlkeiagld tapqirgnet nsretflgri
      181 ndcykrsler klppscmigg iketqgkhvi lsgstevisn eggrfcypef ssgeeseedv
      241 lfsnmeeehe swdesdeell ameirmrgqp rfanfrantl spvrffvdkk wntiplrnks
      301 lqricavdyd dsydeilngy eensvvsygq gsiqsmvssd stspdsslte esrsetassl
      361 sqkicnggls pgnpgdskdm keiepnyesp ssnnqdkdss qaskssikvp ethkavlalr
      421 leekdgkiav qtekeeskas tdvagqavti nlvpteeqak pyrvvnleqp lckpytvvdv
      481 saamasehle gpvnspktks ssstpnspvt sssltpgqis ahfqkssair yqevwtssts
      541 prqkipkvel itsgtgpnvp prknchksap tsptatniss ktipvkspnl seikfnsynn
      601 agmppfpiii hdeptyarss knaikvpivi npnaydnlai yksflgtsge lsvkekttsv
      661 ishtyeeiet eskvpdntts kttdclqtkg fsnstehkrg svaqkvqefn nclnrgqssp
      721 qrsyssshss pakiqratqe pvakiegtqe sqmvgssstr ekastvlsqi vasiqppqsp
      781 petpqsgpka csveelyaip pdadvakstp kstpvrpksl ftsqpsgeae apqttdsptt
      841 kvqkdpsikp vtpspsklvt spqseppapf ppprstsspy hagnllqrhf tnwtkptspt
      901 rsteaesvlh segsrraada kpkrwisfks ffrrrktdee ddkekerekg klvgldgtvi
      961 hmlppppvqr hhwfteakge ssekpaivfm yrcdpaqgql svdqskartd qaavmekgra
     1021 enallqdsek krshsspsqi pkkilshmth evtedfsprd prtvvgkqdg rgctsvttal
     1081 slpeleredg kedisdpmdp npcsatysnl gqsraamipp kqprqpkgav ddaiafggkt
     1141 dqeapnasqp tppplpkkmi irantepisk dlqksmessl cvmanptydi dpnwdassag
     1201 ssisyelkgl diesydsler plrkerpvps aansissltt lsikdrfsns meslssrrgp
     1261 scrqgrgiqk pqrqalyrgl enreevvgki rslhtdalkk lavkcedlfm agqkdqlrfg
     1321 vdswsdfrlt sdkpcceagd avyytasyak dplnnyavki ckskakesqq yyhslavrqs
     1381 lavhfniqqd cghflaevpn rllpwedpdd pekdeddmee teedakgetd gknpkpcsea
     1441 assqkenqgv mskkqrshvv vitrevpclt vadfvrdsla qhgkspdlye rqvcllllql
     1501 csglehlkpy hvthcdlrle nlllvhyqpg gtaqgfgpae psptssyptr livsnfsqak
     1561 qkshlvdpei lrdqsrlape iitatqykkc defqtgiliy emlhlpnpfd enpelkerey
     1621 tradlpripf rspysrglqq lascllnpnp serilisdak gilqcllwgp redlfqtfta
     1681 cpslvqrntl lqnwldikrt llmikfaeks ldreggisle dwlcaqylaf attdslsciv
     1741 kilqhr
//
LOCUS       XP_047289024            1746 aa            linear   PRI 05-AUG-2025
DEFINITION  inactive tyrosine-protein kinase PEAK1 isoform X1 [Homo sapiens].
ACCESSION   XP_047289024
VERSION     XP_047289024.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433068.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1746
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1746
                     /product="inactive tyrosine-protein kinase PEAK1 isoform
                     X1"
                     /calculated_mol_wt=192976
     Region          <1503..1668
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..1746
                     /gene="PEAK1"
                     /gene_synonym="SGK269"
                     /coded_by="XM_047433068.1:2336..7576"
                     /db_xref="GeneID:79834"
                     /db_xref="HGNC:HGNC:29431"
                     /db_xref="MIM:614248"
ORIGIN      
        1 msacntfteh vwkpgecknc fkpkslhqlp pdpekapith gnvktnanhs nnhrirntgn
       61 frppvakkpt iavkptmiva dgqsicgels iqehcenkpv iigwnrnraa lsqkplnnnn
      121 eddegishvp kpygnndsak kmsdnnnglt evlkeiagld tapqirgnet nsretflgri
      181 ndcykrsler klppscmigg iketqgkhvi lsgstevisn eggrfcypef ssgeeseedv
      241 lfsnmeeehe swdesdeell ameirmrgqp rfanfrantl spvrffvdkk wntiplrnks
      301 lqricavdyd dsydeilngy eensvvsygq gsiqsmvssd stspdsslte esrsetassl
      361 sqkicnggls pgnpgdskdm keiepnyesp ssnnqdkdss qaskssikvp ethkavlalr
      421 leekdgkiav qtekeeskas tdvagqavti nlvpteeqak pyrvvnleqp lckpytvvdv
      481 saamasehle gpvnspktks ssstpnspvt sssltpgqis ahfqkssair yqevwtssts
      541 prqkipkvel itsgtgpnvp prknchksap tsptatniss ktipvkspnl seikfnsynn
      601 agmppfpiii hdeptyarss knaikvpivi npnaydnlai yksflgtsge lsvkekttsv
      661 ishtyeeiet eskvpdntts kttdclqtkg fsnstehkrg svaqkvqefn nclnrgqssp
      721 qrsyssshss pakiqratqe pvakiegtqe sqmvgssstr ekastvlsqi vasiqppqsp
      781 petpqsgpka csveelyaip pdadvakstp kstpvrpksl ftsqpsgeae apqttdsptt
      841 kvqkdpsikp vtpspsklvt spqseppapf ppprstsspy hagnllqrhf tnwtkptspt
      901 rsteaesvlh segsrraada kpkrwisfks ffrrrktdee ddkekerekg klvgldgtvi
      961 hmlppppvqr hhwfteakge ssekpaivfm yrcdpaqgql svdqskartd qaavmekgra
     1021 enallqdsek krshsspsqi pkkilshmth evtedfsprd prtvvgkqdg rgctsvttal
     1081 slpeleredg kedisdpmdp npcsatysnl gqsraamipp kqprqpkgav ddaiafggkt
     1141 dqeapnasqp tppplpkkmi irantepisk dlqksmessl cvmanptydi dpnwdassag
     1201 ssisyelkgl diesydsler plrkerpvps aansissltt lsikdrfsns meslssrrgp
     1261 scrqgrgiqk pqrqalyrgl enreevvgki rslhtdalkk lavkcedlfm agqkdqlrfg
     1321 vdswsdfrlt sdkpcceagd avyytasyak dplnnyavki ckskakesqq yyhslavrqs
     1381 lavhfniqqd cghflaevpn rllpwedpdd pekdeddmee teedakgetd gknpkpcsea
     1441 assqkenqgv mskkqrshvv vitrevpclt vadfvrdsla qhgkspdlye rqvcllllql
     1501 csglehlkpy hvthcdlrle nlllvhyqpg gtaqgfgpae psptssyptr livsnfsqak
     1561 qkshlvdpei lrdqsrlape iitatqykkc defqtgiliy emlhlpnpfd enpelkerey
     1621 tradlpripf rspysrglqq lascllnpnp serilisdak gilqcllwgp redlfqtfta
     1681 cpslvqrntl lqnwldikrt llmikfaeks ldreggisle dwlcaqylaf attdslsciv
     1741 kilqhr
//
LOCUS       XP_047289025            1746 aa            linear   PRI 05-AUG-2025
DEFINITION  inactive tyrosine-protein kinase PEAK1 isoform X1 [Homo sapiens].
ACCESSION   XP_047289025
VERSION     XP_047289025.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433069.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1746
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1746
                     /product="inactive tyrosine-protein kinase PEAK1 isoform
                     X1"
                     /calculated_mol_wt=192976
     Region          <1503..1668
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..1746
                     /gene="PEAK1"
                     /gene_synonym="SGK269"
                     /coded_by="XM_047433069.1:1105..6345"
                     /db_xref="GeneID:79834"
                     /db_xref="HGNC:HGNC:29431"
                     /db_xref="MIM:614248"
ORIGIN      
        1 msacntfteh vwkpgecknc fkpkslhqlp pdpekapith gnvktnanhs nnhrirntgn
       61 frppvakkpt iavkptmiva dgqsicgels iqehcenkpv iigwnrnraa lsqkplnnnn
      121 eddegishvp kpygnndsak kmsdnnnglt evlkeiagld tapqirgnet nsretflgri
      181 ndcykrsler klppscmigg iketqgkhvi lsgstevisn eggrfcypef ssgeeseedv
      241 lfsnmeeehe swdesdeell ameirmrgqp rfanfrantl spvrffvdkk wntiplrnks
      301 lqricavdyd dsydeilngy eensvvsygq gsiqsmvssd stspdsslte esrsetassl
      361 sqkicnggls pgnpgdskdm keiepnyesp ssnnqdkdss qaskssikvp ethkavlalr
      421 leekdgkiav qtekeeskas tdvagqavti nlvpteeqak pyrvvnleqp lckpytvvdv
      481 saamasehle gpvnspktks ssstpnspvt sssltpgqis ahfqkssair yqevwtssts
      541 prqkipkvel itsgtgpnvp prknchksap tsptatniss ktipvkspnl seikfnsynn
      601 agmppfpiii hdeptyarss knaikvpivi npnaydnlai yksflgtsge lsvkekttsv
      661 ishtyeeiet eskvpdntts kttdclqtkg fsnstehkrg svaqkvqefn nclnrgqssp
      721 qrsyssshss pakiqratqe pvakiegtqe sqmvgssstr ekastvlsqi vasiqppqsp
      781 petpqsgpka csveelyaip pdadvakstp kstpvrpksl ftsqpsgeae apqttdsptt
      841 kvqkdpsikp vtpspsklvt spqseppapf ppprstsspy hagnllqrhf tnwtkptspt
      901 rsteaesvlh segsrraada kpkrwisfks ffrrrktdee ddkekerekg klvgldgtvi
      961 hmlppppvqr hhwfteakge ssekpaivfm yrcdpaqgql svdqskartd qaavmekgra
     1021 enallqdsek krshsspsqi pkkilshmth evtedfsprd prtvvgkqdg rgctsvttal
     1081 slpeleredg kedisdpmdp npcsatysnl gqsraamipp kqprqpkgav ddaiafggkt
     1141 dqeapnasqp tppplpkkmi irantepisk dlqksmessl cvmanptydi dpnwdassag
     1201 ssisyelkgl diesydsler plrkerpvps aansissltt lsikdrfsns meslssrrgp
     1261 scrqgrgiqk pqrqalyrgl enreevvgki rslhtdalkk lavkcedlfm agqkdqlrfg
     1321 vdswsdfrlt sdkpcceagd avyytasyak dplnnyavki ckskakesqq yyhslavrqs
     1381 lavhfniqqd cghflaevpn rllpwedpdd pekdeddmee teedakgetd gknpkpcsea
     1441 assqkenqgv mskkqrshvv vitrevpclt vadfvrdsla qhgkspdlye rqvcllllql
     1501 csglehlkpy hvthcdlrle nlllvhyqpg gtaqgfgpae psptssyptr livsnfsqak
     1561 qkshlvdpei lrdqsrlape iitatqykkc defqtgiliy emlhlpnpfd enpelkerey
     1621 tradlpripf rspysrglqq lascllnpnp serilisdak gilqcllwgp redlfqtfta
     1681 cpslvqrntl lqnwldikrt llmikfaeks ldreggisle dwlcaqylaf attdslsciv
     1741 kilqhr
//
LOCUS       XP_047289026            1746 aa            linear   PRI 05-AUG-2025
DEFINITION  inactive tyrosine-protein kinase PEAK1 isoform X1 [Homo sapiens].
ACCESSION   XP_047289026
VERSION     XP_047289026.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433070.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1746
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1746
                     /product="inactive tyrosine-protein kinase PEAK1 isoform
                     X1"
                     /calculated_mol_wt=192976
     Region          <1503..1668
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..1746
                     /gene="PEAK1"
                     /gene_synonym="SGK269"
                     /coded_by="XM_047433070.1:1106..6346"
                     /db_xref="GeneID:79834"
                     /db_xref="HGNC:HGNC:29431"
                     /db_xref="MIM:614248"
ORIGIN      
        1 msacntfteh vwkpgecknc fkpkslhqlp pdpekapith gnvktnanhs nnhrirntgn
       61 frppvakkpt iavkptmiva dgqsicgels iqehcenkpv iigwnrnraa lsqkplnnnn
      121 eddegishvp kpygnndsak kmsdnnnglt evlkeiagld tapqirgnet nsretflgri
      181 ndcykrsler klppscmigg iketqgkhvi lsgstevisn eggrfcypef ssgeeseedv
      241 lfsnmeeehe swdesdeell ameirmrgqp rfanfrantl spvrffvdkk wntiplrnks
      301 lqricavdyd dsydeilngy eensvvsygq gsiqsmvssd stspdsslte esrsetassl
      361 sqkicnggls pgnpgdskdm keiepnyesp ssnnqdkdss qaskssikvp ethkavlalr
      421 leekdgkiav qtekeeskas tdvagqavti nlvpteeqak pyrvvnleqp lckpytvvdv
      481 saamasehle gpvnspktks ssstpnspvt sssltpgqis ahfqkssair yqevwtssts
      541 prqkipkvel itsgtgpnvp prknchksap tsptatniss ktipvkspnl seikfnsynn
      601 agmppfpiii hdeptyarss knaikvpivi npnaydnlai yksflgtsge lsvkekttsv
      661 ishtyeeiet eskvpdntts kttdclqtkg fsnstehkrg svaqkvqefn nclnrgqssp
      721 qrsyssshss pakiqratqe pvakiegtqe sqmvgssstr ekastvlsqi vasiqppqsp
      781 petpqsgpka csveelyaip pdadvakstp kstpvrpksl ftsqpsgeae apqttdsptt
      841 kvqkdpsikp vtpspsklvt spqseppapf ppprstsspy hagnllqrhf tnwtkptspt
      901 rsteaesvlh segsrraada kpkrwisfks ffrrrktdee ddkekerekg klvgldgtvi
      961 hmlppppvqr hhwfteakge ssekpaivfm yrcdpaqgql svdqskartd qaavmekgra
     1021 enallqdsek krshsspsqi pkkilshmth evtedfsprd prtvvgkqdg rgctsvttal
     1081 slpeleredg kedisdpmdp npcsatysnl gqsraamipp kqprqpkgav ddaiafggkt
     1141 dqeapnasqp tppplpkkmi irantepisk dlqksmessl cvmanptydi dpnwdassag
     1201 ssisyelkgl diesydsler plrkerpvps aansissltt lsikdrfsns meslssrrgp
     1261 scrqgrgiqk pqrqalyrgl enreevvgki rslhtdalkk lavkcedlfm agqkdqlrfg
     1321 vdswsdfrlt sdkpcceagd avyytasyak dplnnyavki ckskakesqq yyhslavrqs
     1381 lavhfniqqd cghflaevpn rllpwedpdd pekdeddmee teedakgetd gknpkpcsea
     1441 assqkenqgv mskkqrshvv vitrevpclt vadfvrdsla qhgkspdlye rqvcllllql
     1501 csglehlkpy hvthcdlrle nlllvhyqpg gtaqgfgpae psptssyptr livsnfsqak
     1561 qkshlvdpei lrdqsrlape iitatqykkc defqtgiliy emlhlpnpfd enpelkerey
     1621 tradlpripf rspysrglqq lascllnpnp serilisdak gilqcllwgp redlfqtfta
     1681 cpslvqrntl lqnwldikrt llmikfaeks ldreggisle dwlcaqylaf attdslsciv
     1741 kilqhr
//
LOCUS       XP_047289027            1746 aa            linear   PRI 05-AUG-2025
DEFINITION  inactive tyrosine-protein kinase PEAK1 isoform X1 [Homo sapiens].
ACCESSION   XP_047289027
VERSION     XP_047289027.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433071.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1746
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1746
                     /product="inactive tyrosine-protein kinase PEAK1 isoform
                     X1"
                     /calculated_mol_wt=192976
     Region          <1503..1668
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..1746
                     /gene="PEAK1"
                     /gene_synonym="SGK269"
                     /coded_by="XM_047433071.1:5396..10636"
                     /db_xref="GeneID:79834"
                     /db_xref="HGNC:HGNC:29431"
                     /db_xref="MIM:614248"
ORIGIN      
        1 msacntfteh vwkpgecknc fkpkslhqlp pdpekapith gnvktnanhs nnhrirntgn
       61 frppvakkpt iavkptmiva dgqsicgels iqehcenkpv iigwnrnraa lsqkplnnnn
      121 eddegishvp kpygnndsak kmsdnnnglt evlkeiagld tapqirgnet nsretflgri
      181 ndcykrsler klppscmigg iketqgkhvi lsgstevisn eggrfcypef ssgeeseedv
      241 lfsnmeeehe swdesdeell ameirmrgqp rfanfrantl spvrffvdkk wntiplrnks
      301 lqricavdyd dsydeilngy eensvvsygq gsiqsmvssd stspdsslte esrsetassl
      361 sqkicnggls pgnpgdskdm keiepnyesp ssnnqdkdss qaskssikvp ethkavlalr
      421 leekdgkiav qtekeeskas tdvagqavti nlvpteeqak pyrvvnleqp lckpytvvdv
      481 saamasehle gpvnspktks ssstpnspvt sssltpgqis ahfqkssair yqevwtssts
      541 prqkipkvel itsgtgpnvp prknchksap tsptatniss ktipvkspnl seikfnsynn
      601 agmppfpiii hdeptyarss knaikvpivi npnaydnlai yksflgtsge lsvkekttsv
      661 ishtyeeiet eskvpdntts kttdclqtkg fsnstehkrg svaqkvqefn nclnrgqssp
      721 qrsyssshss pakiqratqe pvakiegtqe sqmvgssstr ekastvlsqi vasiqppqsp
      781 petpqsgpka csveelyaip pdadvakstp kstpvrpksl ftsqpsgeae apqttdsptt
      841 kvqkdpsikp vtpspsklvt spqseppapf ppprstsspy hagnllqrhf tnwtkptspt
      901 rsteaesvlh segsrraada kpkrwisfks ffrrrktdee ddkekerekg klvgldgtvi
      961 hmlppppvqr hhwfteakge ssekpaivfm yrcdpaqgql svdqskartd qaavmekgra
     1021 enallqdsek krshsspsqi pkkilshmth evtedfsprd prtvvgkqdg rgctsvttal
     1081 slpeleredg kedisdpmdp npcsatysnl gqsraamipp kqprqpkgav ddaiafggkt
     1141 dqeapnasqp tppplpkkmi irantepisk dlqksmessl cvmanptydi dpnwdassag
     1201 ssisyelkgl diesydsler plrkerpvps aansissltt lsikdrfsns meslssrrgp
     1261 scrqgrgiqk pqrqalyrgl enreevvgki rslhtdalkk lavkcedlfm agqkdqlrfg
     1321 vdswsdfrlt sdkpcceagd avyytasyak dplnnyavki ckskakesqq yyhslavrqs
     1381 lavhfniqqd cghflaevpn rllpwedpdd pekdeddmee teedakgetd gknpkpcsea
     1441 assqkenqgv mskkqrshvv vitrevpclt vadfvrdsla qhgkspdlye rqvcllllql
     1501 csglehlkpy hvthcdlrle nlllvhyqpg gtaqgfgpae psptssyptr livsnfsqak
     1561 qkshlvdpei lrdqsrlape iitatqykkc defqtgiliy emlhlpnpfd enpelkerey
     1621 tradlpripf rspysrglqq lascllnpnp serilisdak gilqcllwgp redlfqtfta
     1681 cpslvqrntl lqnwldikrt llmikfaeks ldreggisle dwlcaqylaf attdslsciv
     1741 kilqhr
//
LOCUS       XP_005254732            1746 aa            linear   PRI 05-AUG-2025
DEFINITION  inactive tyrosine-protein kinase PEAK1 isoform X1 [Homo sapiens].
ACCESSION   XP_005254732
VERSION     XP_005254732.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254675.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1746
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1746
                     /product="inactive tyrosine-protein kinase PEAK1 isoform
                     X1"
                     /calculated_mol_wt=192976
     Region          <1503..1668
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..1746
                     /gene="PEAK1"
                     /gene_synonym="SGK269"
                     /coded_by="XM_005254675.5:482..5722"
                     /db_xref="GeneID:79834"
                     /db_xref="HGNC:HGNC:29431"
                     /db_xref="MIM:614248"
ORIGIN      
        1 msacntfteh vwkpgecknc fkpkslhqlp pdpekapith gnvktnanhs nnhrirntgn
       61 frppvakkpt iavkptmiva dgqsicgels iqehcenkpv iigwnrnraa lsqkplnnnn
      121 eddegishvp kpygnndsak kmsdnnnglt evlkeiagld tapqirgnet nsretflgri
      181 ndcykrsler klppscmigg iketqgkhvi lsgstevisn eggrfcypef ssgeeseedv
      241 lfsnmeeehe swdesdeell ameirmrgqp rfanfrantl spvrffvdkk wntiplrnks
      301 lqricavdyd dsydeilngy eensvvsygq gsiqsmvssd stspdsslte esrsetassl
      361 sqkicnggls pgnpgdskdm keiepnyesp ssnnqdkdss qaskssikvp ethkavlalr
      421 leekdgkiav qtekeeskas tdvagqavti nlvpteeqak pyrvvnleqp lckpytvvdv
      481 saamasehle gpvnspktks ssstpnspvt sssltpgqis ahfqkssair yqevwtssts
      541 prqkipkvel itsgtgpnvp prknchksap tsptatniss ktipvkspnl seikfnsynn
      601 agmppfpiii hdeptyarss knaikvpivi npnaydnlai yksflgtsge lsvkekttsv
      661 ishtyeeiet eskvpdntts kttdclqtkg fsnstehkrg svaqkvqefn nclnrgqssp
      721 qrsyssshss pakiqratqe pvakiegtqe sqmvgssstr ekastvlsqi vasiqppqsp
      781 petpqsgpka csveelyaip pdadvakstp kstpvrpksl ftsqpsgeae apqttdsptt
      841 kvqkdpsikp vtpspsklvt spqseppapf ppprstsspy hagnllqrhf tnwtkptspt
      901 rsteaesvlh segsrraada kpkrwisfks ffrrrktdee ddkekerekg klvgldgtvi
      961 hmlppppvqr hhwfteakge ssekpaivfm yrcdpaqgql svdqskartd qaavmekgra
     1021 enallqdsek krshsspsqi pkkilshmth evtedfsprd prtvvgkqdg rgctsvttal
     1081 slpeleredg kedisdpmdp npcsatysnl gqsraamipp kqprqpkgav ddaiafggkt
     1141 dqeapnasqp tppplpkkmi irantepisk dlqksmessl cvmanptydi dpnwdassag
     1201 ssisyelkgl diesydsler plrkerpvps aansissltt lsikdrfsns meslssrrgp
     1261 scrqgrgiqk pqrqalyrgl enreevvgki rslhtdalkk lavkcedlfm agqkdqlrfg
     1321 vdswsdfrlt sdkpcceagd avyytasyak dplnnyavki ckskakesqq yyhslavrqs
     1381 lavhfniqqd cghflaevpn rllpwedpdd pekdeddmee teedakgetd gknpkpcsea
     1441 assqkenqgv mskkqrshvv vitrevpclt vadfvrdsla qhgkspdlye rqvcllllql
     1501 csglehlkpy hvthcdlrle nlllvhyqpg gtaqgfgpae psptssyptr livsnfsqak
     1561 qkshlvdpei lrdqsrlape iitatqykkc defqtgiliy emlhlpnpfd enpelkerey
     1621 tradlpripf rspysrglqq lascllnpnp serilisdak gilqcllwgp redlfqtfta
     1681 cpslvqrntl lqnwldikrt llmikfaeks ldreggisle dwlcaqylaf attdslsciv
     1741 kilqhr
//
LOCUS       XP_047289028            1746 aa            linear   PRI 05-AUG-2025
DEFINITION  inactive tyrosine-protein kinase PEAK1 isoform X1 [Homo sapiens].
ACCESSION   XP_047289028
VERSION     XP_047289028.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433072.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1746
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1746
                     /product="inactive tyrosine-protein kinase PEAK1 isoform
                     X1"
                     /calculated_mol_wt=192976
     Region          <1503..1668
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..1746
                     /gene="PEAK1"
                     /gene_synonym="SGK269"
                     /coded_by="XM_047433072.1:2726..7966"
                     /db_xref="GeneID:79834"
                     /db_xref="HGNC:HGNC:29431"
                     /db_xref="MIM:614248"
ORIGIN      
        1 msacntfteh vwkpgecknc fkpkslhqlp pdpekapith gnvktnanhs nnhrirntgn
       61 frppvakkpt iavkptmiva dgqsicgels iqehcenkpv iigwnrnraa lsqkplnnnn
      121 eddegishvp kpygnndsak kmsdnnnglt evlkeiagld tapqirgnet nsretflgri
      181 ndcykrsler klppscmigg iketqgkhvi lsgstevisn eggrfcypef ssgeeseedv
      241 lfsnmeeehe swdesdeell ameirmrgqp rfanfrantl spvrffvdkk wntiplrnks
      301 lqricavdyd dsydeilngy eensvvsygq gsiqsmvssd stspdsslte esrsetassl
      361 sqkicnggls pgnpgdskdm keiepnyesp ssnnqdkdss qaskssikvp ethkavlalr
      421 leekdgkiav qtekeeskas tdvagqavti nlvpteeqak pyrvvnleqp lckpytvvdv
      481 saamasehle gpvnspktks ssstpnspvt sssltpgqis ahfqkssair yqevwtssts
      541 prqkipkvel itsgtgpnvp prknchksap tsptatniss ktipvkspnl seikfnsynn
      601 agmppfpiii hdeptyarss knaikvpivi npnaydnlai yksflgtsge lsvkekttsv
      661 ishtyeeiet eskvpdntts kttdclqtkg fsnstehkrg svaqkvqefn nclnrgqssp
      721 qrsyssshss pakiqratqe pvakiegtqe sqmvgssstr ekastvlsqi vasiqppqsp
      781 petpqsgpka csveelyaip pdadvakstp kstpvrpksl ftsqpsgeae apqttdsptt
      841 kvqkdpsikp vtpspsklvt spqseppapf ppprstsspy hagnllqrhf tnwtkptspt
      901 rsteaesvlh segsrraada kpkrwisfks ffrrrktdee ddkekerekg klvgldgtvi
      961 hmlppppvqr hhwfteakge ssekpaivfm yrcdpaqgql svdqskartd qaavmekgra
     1021 enallqdsek krshsspsqi pkkilshmth evtedfsprd prtvvgkqdg rgctsvttal
     1081 slpeleredg kedisdpmdp npcsatysnl gqsraamipp kqprqpkgav ddaiafggkt
     1141 dqeapnasqp tppplpkkmi irantepisk dlqksmessl cvmanptydi dpnwdassag
     1201 ssisyelkgl diesydsler plrkerpvps aansissltt lsikdrfsns meslssrrgp
     1261 scrqgrgiqk pqrqalyrgl enreevvgki rslhtdalkk lavkcedlfm agqkdqlrfg
     1321 vdswsdfrlt sdkpcceagd avyytasyak dplnnyavki ckskakesqq yyhslavrqs
     1381 lavhfniqqd cghflaevpn rllpwedpdd pekdeddmee teedakgetd gknpkpcsea
     1441 assqkenqgv mskkqrshvv vitrevpclt vadfvrdsla qhgkspdlye rqvcllllql
     1501 csglehlkpy hvthcdlrle nlllvhyqpg gtaqgfgpae psptssyptr livsnfsqak
     1561 qkshlvdpei lrdqsrlape iitatqykkc defqtgiliy emlhlpnpfd enpelkerey
     1621 tradlpripf rspysrglqq lascllnpnp serilisdak gilqcllwgp redlfqtfta
     1681 cpslvqrntl lqnwldikrt llmikfaeks ldreggisle dwlcaqylaf attdslsciv
     1741 kilqhr
//
LOCUS       XP_047289029            1746 aa            linear   PRI 05-AUG-2025
DEFINITION  inactive tyrosine-protein kinase PEAK1 isoform X1 [Homo sapiens].
ACCESSION   XP_047289029
VERSION     XP_047289029.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433073.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1746
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1746
                     /product="inactive tyrosine-protein kinase PEAK1 isoform
                     X1"
                     /calculated_mol_wt=192976
     Region          <1503..1668
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..1746
                     /gene="PEAK1"
                     /gene_synonym="SGK269"
                     /coded_by="XM_047433073.1:2609..7849"
                     /db_xref="GeneID:79834"
                     /db_xref="HGNC:HGNC:29431"
                     /db_xref="MIM:614248"
ORIGIN      
        1 msacntfteh vwkpgecknc fkpkslhqlp pdpekapith gnvktnanhs nnhrirntgn
       61 frppvakkpt iavkptmiva dgqsicgels iqehcenkpv iigwnrnraa lsqkplnnnn
      121 eddegishvp kpygnndsak kmsdnnnglt evlkeiagld tapqirgnet nsretflgri
      181 ndcykrsler klppscmigg iketqgkhvi lsgstevisn eggrfcypef ssgeeseedv
      241 lfsnmeeehe swdesdeell ameirmrgqp rfanfrantl spvrffvdkk wntiplrnks
      301 lqricavdyd dsydeilngy eensvvsygq gsiqsmvssd stspdsslte esrsetassl
      361 sqkicnggls pgnpgdskdm keiepnyesp ssnnqdkdss qaskssikvp ethkavlalr
      421 leekdgkiav qtekeeskas tdvagqavti nlvpteeqak pyrvvnleqp lckpytvvdv
      481 saamasehle gpvnspktks ssstpnspvt sssltpgqis ahfqkssair yqevwtssts
      541 prqkipkvel itsgtgpnvp prknchksap tsptatniss ktipvkspnl seikfnsynn
      601 agmppfpiii hdeptyarss knaikvpivi npnaydnlai yksflgtsge lsvkekttsv
      661 ishtyeeiet eskvpdntts kttdclqtkg fsnstehkrg svaqkvqefn nclnrgqssp
      721 qrsyssshss pakiqratqe pvakiegtqe sqmvgssstr ekastvlsqi vasiqppqsp
      781 petpqsgpka csveelyaip pdadvakstp kstpvrpksl ftsqpsgeae apqttdsptt
      841 kvqkdpsikp vtpspsklvt spqseppapf ppprstsspy hagnllqrhf tnwtkptspt
      901 rsteaesvlh segsrraada kpkrwisfks ffrrrktdee ddkekerekg klvgldgtvi
      961 hmlppppvqr hhwfteakge ssekpaivfm yrcdpaqgql svdqskartd qaavmekgra
     1021 enallqdsek krshsspsqi pkkilshmth evtedfsprd prtvvgkqdg rgctsvttal
     1081 slpeleredg kedisdpmdp npcsatysnl gqsraamipp kqprqpkgav ddaiafggkt
     1141 dqeapnasqp tppplpkkmi irantepisk dlqksmessl cvmanptydi dpnwdassag
     1201 ssisyelkgl diesydsler plrkerpvps aansissltt lsikdrfsns meslssrrgp
     1261 scrqgrgiqk pqrqalyrgl enreevvgki rslhtdalkk lavkcedlfm agqkdqlrfg
     1321 vdswsdfrlt sdkpcceagd avyytasyak dplnnyavki ckskakesqq yyhslavrqs
     1381 lavhfniqqd cghflaevpn rllpwedpdd pekdeddmee teedakgetd gknpkpcsea
     1441 assqkenqgv mskkqrshvv vitrevpclt vadfvrdsla qhgkspdlye rqvcllllql
     1501 csglehlkpy hvthcdlrle nlllvhyqpg gtaqgfgpae psptssyptr livsnfsqak
     1561 qkshlvdpei lrdqsrlape iitatqykkc defqtgiliy emlhlpnpfd enpelkerey
     1621 tradlpripf rspysrglqq lascllnpnp serilisdak gilqcllwgp redlfqtfta
     1681 cpslvqrntl lqnwldikrt llmikfaeks ldreggisle dwlcaqylaf attdslsciv
     1741 kilqhr
//
LOCUS       XP_047289030            1746 aa            linear   PRI 05-AUG-2025
DEFINITION  inactive tyrosine-protein kinase PEAK1 isoform X1 [Homo sapiens].
ACCESSION   XP_047289030
VERSION     XP_047289030.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433074.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1746
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1746
                     /product="inactive tyrosine-protein kinase PEAK1 isoform
                     X1"
                     /calculated_mol_wt=192976
     Region          <1503..1668
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..1746
                     /gene="PEAK1"
                     /gene_synonym="SGK269"
                     /coded_by="XM_047433074.1:1246..6486"
                     /db_xref="GeneID:79834"
                     /db_xref="HGNC:HGNC:29431"
                     /db_xref="MIM:614248"
ORIGIN      
        1 msacntfteh vwkpgecknc fkpkslhqlp pdpekapith gnvktnanhs nnhrirntgn
       61 frppvakkpt iavkptmiva dgqsicgels iqehcenkpv iigwnrnraa lsqkplnnnn
      121 eddegishvp kpygnndsak kmsdnnnglt evlkeiagld tapqirgnet nsretflgri
      181 ndcykrsler klppscmigg iketqgkhvi lsgstevisn eggrfcypef ssgeeseedv
      241 lfsnmeeehe swdesdeell ameirmrgqp rfanfrantl spvrffvdkk wntiplrnks
      301 lqricavdyd dsydeilngy eensvvsygq gsiqsmvssd stspdsslte esrsetassl
      361 sqkicnggls pgnpgdskdm keiepnyesp ssnnqdkdss qaskssikvp ethkavlalr
      421 leekdgkiav qtekeeskas tdvagqavti nlvpteeqak pyrvvnleqp lckpytvvdv
      481 saamasehle gpvnspktks ssstpnspvt sssltpgqis ahfqkssair yqevwtssts
      541 prqkipkvel itsgtgpnvp prknchksap tsptatniss ktipvkspnl seikfnsynn
      601 agmppfpiii hdeptyarss knaikvpivi npnaydnlai yksflgtsge lsvkekttsv
      661 ishtyeeiet eskvpdntts kttdclqtkg fsnstehkrg svaqkvqefn nclnrgqssp
      721 qrsyssshss pakiqratqe pvakiegtqe sqmvgssstr ekastvlsqi vasiqppqsp
      781 petpqsgpka csveelyaip pdadvakstp kstpvrpksl ftsqpsgeae apqttdsptt
      841 kvqkdpsikp vtpspsklvt spqseppapf ppprstsspy hagnllqrhf tnwtkptspt
      901 rsteaesvlh segsrraada kpkrwisfks ffrrrktdee ddkekerekg klvgldgtvi
      961 hmlppppvqr hhwfteakge ssekpaivfm yrcdpaqgql svdqskartd qaavmekgra
     1021 enallqdsek krshsspsqi pkkilshmth evtedfsprd prtvvgkqdg rgctsvttal
     1081 slpeleredg kedisdpmdp npcsatysnl gqsraamipp kqprqpkgav ddaiafggkt
     1141 dqeapnasqp tppplpkkmi irantepisk dlqksmessl cvmanptydi dpnwdassag
     1201 ssisyelkgl diesydsler plrkerpvps aansissltt lsikdrfsns meslssrrgp
     1261 scrqgrgiqk pqrqalyrgl enreevvgki rslhtdalkk lavkcedlfm agqkdqlrfg
     1321 vdswsdfrlt sdkpcceagd avyytasyak dplnnyavki ckskakesqq yyhslavrqs
     1381 lavhfniqqd cghflaevpn rllpwedpdd pekdeddmee teedakgetd gknpkpcsea
     1441 assqkenqgv mskkqrshvv vitrevpclt vadfvrdsla qhgkspdlye rqvcllllql
     1501 csglehlkpy hvthcdlrle nlllvhyqpg gtaqgfgpae psptssyptr livsnfsqak
     1561 qkshlvdpei lrdqsrlape iitatqykkc defqtgiliy emlhlpnpfd enpelkerey
     1621 tradlpripf rspysrglqq lascllnpnp serilisdak gilqcllwgp redlfqtfta
     1681 cpslvqrntl lqnwldikrt llmikfaeks ldreggisle dwlcaqylaf attdslsciv
     1741 kilqhr
//
LOCUS       XP_047289031            1746 aa            linear   PRI 05-AUG-2025
DEFINITION  inactive tyrosine-protein kinase PEAK1 isoform X1 [Homo sapiens].
ACCESSION   XP_047289031
VERSION     XP_047289031.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433075.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1746
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1746
                     /product="inactive tyrosine-protein kinase PEAK1 isoform
                     X1"
                     /calculated_mol_wt=192976
     Region          <1503..1668
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..1746
                     /gene="PEAK1"
                     /gene_synonym="SGK269"
                     /coded_by="XM_047433075.1:912..6152"
                     /db_xref="GeneID:79834"
                     /db_xref="HGNC:HGNC:29431"
                     /db_xref="MIM:614248"
ORIGIN      
        1 msacntfteh vwkpgecknc fkpkslhqlp pdpekapith gnvktnanhs nnhrirntgn
       61 frppvakkpt iavkptmiva dgqsicgels iqehcenkpv iigwnrnraa lsqkplnnnn
      121 eddegishvp kpygnndsak kmsdnnnglt evlkeiagld tapqirgnet nsretflgri
      181 ndcykrsler klppscmigg iketqgkhvi lsgstevisn eggrfcypef ssgeeseedv
      241 lfsnmeeehe swdesdeell ameirmrgqp rfanfrantl spvrffvdkk wntiplrnks
      301 lqricavdyd dsydeilngy eensvvsygq gsiqsmvssd stspdsslte esrsetassl
      361 sqkicnggls pgnpgdskdm keiepnyesp ssnnqdkdss qaskssikvp ethkavlalr
      421 leekdgkiav qtekeeskas tdvagqavti nlvpteeqak pyrvvnleqp lckpytvvdv
      481 saamasehle gpvnspktks ssstpnspvt sssltpgqis ahfqkssair yqevwtssts
      541 prqkipkvel itsgtgpnvp prknchksap tsptatniss ktipvkspnl seikfnsynn
      601 agmppfpiii hdeptyarss knaikvpivi npnaydnlai yksflgtsge lsvkekttsv
      661 ishtyeeiet eskvpdntts kttdclqtkg fsnstehkrg svaqkvqefn nclnrgqssp
      721 qrsyssshss pakiqratqe pvakiegtqe sqmvgssstr ekastvlsqi vasiqppqsp
      781 petpqsgpka csveelyaip pdadvakstp kstpvrpksl ftsqpsgeae apqttdsptt
      841 kvqkdpsikp vtpspsklvt spqseppapf ppprstsspy hagnllqrhf tnwtkptspt
      901 rsteaesvlh segsrraada kpkrwisfks ffrrrktdee ddkekerekg klvgldgtvi
      961 hmlppppvqr hhwfteakge ssekpaivfm yrcdpaqgql svdqskartd qaavmekgra
     1021 enallqdsek krshsspsqi pkkilshmth evtedfsprd prtvvgkqdg rgctsvttal
     1081 slpeleredg kedisdpmdp npcsatysnl gqsraamipp kqprqpkgav ddaiafggkt
     1141 dqeapnasqp tppplpkkmi irantepisk dlqksmessl cvmanptydi dpnwdassag
     1201 ssisyelkgl diesydsler plrkerpvps aansissltt lsikdrfsns meslssrrgp
     1261 scrqgrgiqk pqrqalyrgl enreevvgki rslhtdalkk lavkcedlfm agqkdqlrfg
     1321 vdswsdfrlt sdkpcceagd avyytasyak dplnnyavki ckskakesqq yyhslavrqs
     1381 lavhfniqqd cghflaevpn rllpwedpdd pekdeddmee teedakgetd gknpkpcsea
     1441 assqkenqgv mskkqrshvv vitrevpclt vadfvrdsla qhgkspdlye rqvcllllql
     1501 csglehlkpy hvthcdlrle nlllvhyqpg gtaqgfgpae psptssyptr livsnfsqak
     1561 qkshlvdpei lrdqsrlape iitatqykkc defqtgiliy emlhlpnpfd enpelkerey
     1621 tradlpripf rspysrglqq lascllnpnp serilisdak gilqcllwgp redlfqtfta
     1681 cpslvqrntl lqnwldikrt llmikfaeks ldreggisle dwlcaqylaf attdslsciv
     1741 kilqhr
//
LOCUS       XP_047289032            1746 aa            linear   PRI 05-AUG-2025
DEFINITION  inactive tyrosine-protein kinase PEAK1 isoform X1 [Homo sapiens].
ACCESSION   XP_047289032
VERSION     XP_047289032.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433076.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1746
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1746
                     /product="inactive tyrosine-protein kinase PEAK1 isoform
                     X1"
                     /calculated_mol_wt=192976
     Region          <1503..1668
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..1746
                     /gene="PEAK1"
                     /gene_synonym="SGK269"
                     /coded_by="XM_047433076.1:1132..6372"
                     /db_xref="GeneID:79834"
                     /db_xref="HGNC:HGNC:29431"
                     /db_xref="MIM:614248"
ORIGIN      
        1 msacntfteh vwkpgecknc fkpkslhqlp pdpekapith gnvktnanhs nnhrirntgn
       61 frppvakkpt iavkptmiva dgqsicgels iqehcenkpv iigwnrnraa lsqkplnnnn
      121 eddegishvp kpygnndsak kmsdnnnglt evlkeiagld tapqirgnet nsretflgri
      181 ndcykrsler klppscmigg iketqgkhvi lsgstevisn eggrfcypef ssgeeseedv
      241 lfsnmeeehe swdesdeell ameirmrgqp rfanfrantl spvrffvdkk wntiplrnks
      301 lqricavdyd dsydeilngy eensvvsygq gsiqsmvssd stspdsslte esrsetassl
      361 sqkicnggls pgnpgdskdm keiepnyesp ssnnqdkdss qaskssikvp ethkavlalr
      421 leekdgkiav qtekeeskas tdvagqavti nlvpteeqak pyrvvnleqp lckpytvvdv
      481 saamasehle gpvnspktks ssstpnspvt sssltpgqis ahfqkssair yqevwtssts
      541 prqkipkvel itsgtgpnvp prknchksap tsptatniss ktipvkspnl seikfnsynn
      601 agmppfpiii hdeptyarss knaikvpivi npnaydnlai yksflgtsge lsvkekttsv
      661 ishtyeeiet eskvpdntts kttdclqtkg fsnstehkrg svaqkvqefn nclnrgqssp
      721 qrsyssshss pakiqratqe pvakiegtqe sqmvgssstr ekastvlsqi vasiqppqsp
      781 petpqsgpka csveelyaip pdadvakstp kstpvrpksl ftsqpsgeae apqttdsptt
      841 kvqkdpsikp vtpspsklvt spqseppapf ppprstsspy hagnllqrhf tnwtkptspt
      901 rsteaesvlh segsrraada kpkrwisfks ffrrrktdee ddkekerekg klvgldgtvi
      961 hmlppppvqr hhwfteakge ssekpaivfm yrcdpaqgql svdqskartd qaavmekgra
     1021 enallqdsek krshsspsqi pkkilshmth evtedfsprd prtvvgkqdg rgctsvttal
     1081 slpeleredg kedisdpmdp npcsatysnl gqsraamipp kqprqpkgav ddaiafggkt
     1141 dqeapnasqp tppplpkkmi irantepisk dlqksmessl cvmanptydi dpnwdassag
     1201 ssisyelkgl diesydsler plrkerpvps aansissltt lsikdrfsns meslssrrgp
     1261 scrqgrgiqk pqrqalyrgl enreevvgki rslhtdalkk lavkcedlfm agqkdqlrfg
     1321 vdswsdfrlt sdkpcceagd avyytasyak dplnnyavki ckskakesqq yyhslavrqs
     1381 lavhfniqqd cghflaevpn rllpwedpdd pekdeddmee teedakgetd gknpkpcsea
     1441 assqkenqgv mskkqrshvv vitrevpclt vadfvrdsla qhgkspdlye rqvcllllql
     1501 csglehlkpy hvthcdlrle nlllvhyqpg gtaqgfgpae psptssyptr livsnfsqak
     1561 qkshlvdpei lrdqsrlape iitatqykkc defqtgiliy emlhlpnpfd enpelkerey
     1621 tradlpripf rspysrglqq lascllnpnp serilisdak gilqcllwgp redlfqtfta
     1681 cpslvqrntl lqnwldikrt llmikfaeks ldreggisle dwlcaqylaf attdslsciv
     1741 kilqhr
//
LOCUS       XP_047289033            1366 aa            linear   PRI 05-AUG-2025
DEFINITION  inactive tyrosine-protein kinase PEAK1 isoform X2 [Homo sapiens].
ACCESSION   XP_047289033
VERSION     XP_047289033.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433077.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1366
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1366
                     /product="inactive tyrosine-protein kinase PEAK1 isoform
                     X2"
                     /calculated_mol_wt=149708
     CDS             1..1366
                     /gene="PEAK1"
                     /gene_synonym="SGK269"
                     /coded_by="XM_047433077.1:1055..5155"
                     /db_xref="GeneID:79834"
                     /db_xref="HGNC:HGNC:29431"
                     /db_xref="MIM:614248"
ORIGIN      
        1 msacntfteh vwkpgecknc fkpkslhqlp pdpekapith gnvktnanhs nnhrirntgn
       61 frppvakkpt iavkptmiva dgqsicgels iqehcenkpv iigwnrnraa lsqkplnnnn
      121 eddegishvp kpygnndsak kmsdnnnglt evlkeiagld tapqirgnet nsretflgri
      181 ndcykrsler klppscmigg iketqgkhvi lsgstevisn eggrfcypef ssgeeseedv
      241 lfsnmeeehe swdesdeell ameirmrgqp rfanfrantl spvrffvdkk wntiplrnks
      301 lqricavdyd dsydeilngy eensvvsygq gsiqsmvssd stspdsslte esrsetassl
      361 sqkicnggls pgnpgdskdm keiepnyesp ssnnqdkdss qaskssikvp ethkavlalr
      421 leekdgkiav qtekeeskas tdvagqavti nlvpteeqak pyrvvnleqp lckpytvvdv
      481 saamasehle gpvnspktks ssstpnspvt sssltpgqis ahfqkssair yqevwtssts
      541 prqkipkvel itsgtgpnvp prknchksap tsptatniss ktipvkspnl seikfnsynn
      601 agmppfpiii hdeptyarss knaikvpivi npnaydnlai yksflgtsge lsvkekttsv
      661 ishtyeeiet eskvpdntts kttdclqtkg fsnstehkrg svaqkvqefn nclnrgqssp
      721 qrsyssshss pakiqratqe pvakiegtqe sqmvgssstr ekastvlsqi vasiqppqsp
      781 petpqsgpka csveelyaip pdadvakstp kstpvrpksl ftsqpsgeae apqttdsptt
      841 kvqkdpsikp vtpspsklvt spqseppapf ppprstsspy hagnllqrhf tnwtkptspt
      901 rsteaesvlh segsrraada kpkrwisfks ffrrrktdee ddkekerekg klvgldgtvi
      961 hmlppppvqr hhwfteakge ssekpaivfm yrcdpaqgql svdqskartd qaavmekgra
     1021 enallqdsek krshsspsqi pkkilshmth evtedfsprd prtvvgkqdg rgctsvttal
     1081 slpeleredg kedisdpmdp npcsatysnl gqsraamipp kqprqpkgav ddaiafggkt
     1141 dqeapnasqp tppplpkkmi irantepisk dlqksmessl cvmanptydi dpnwdassag
     1201 ssisyelkgl diesydsler plrkerpvps aansissltt lsikdrfsns meslssrrgp
     1261 scrqgrgiqk pqrqalyrgl enreevvgki rslhtdalkk lavkcedlfm agqkdqlrfg
     1321 vdswsdfrlt sdkpcceagd avyytasyak dplnnyavkd ssgdfc
//
LOCUS       XP_047289034            1046 aa            linear   PRI 05-AUG-2025
DEFINITION  inactive tyrosine-protein kinase PEAK1 isoform X3 [Homo sapiens].
ACCESSION   XP_047289034
VERSION     XP_047289034.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433078.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1046
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1046
                     /product="inactive tyrosine-protein kinase PEAK1 isoform
                     X3"
                     /calculated_mol_wt=114649
     CDS             1..1046
                     /gene="PEAK1"
                     /gene_synonym="SGK269"
                     /coded_by="XM_047433078.1:1055..4195"
                     /db_xref="GeneID:79834"
                     /db_xref="HGNC:HGNC:29431"
                     /db_xref="MIM:614248"
ORIGIN      
        1 msacntfteh vwkpgecknc fkpkslhqlp pdpekapith gnvktnanhs nnhrirntgn
       61 frppvakkpt iavkptmiva dgqsicgels iqehcenkpv iigwnrnraa lsqkplnnnn
      121 eddegishvp kpygnndsak kmsdnnnglt evlkeiagld tapqirgnet nsretflgri
      181 ndcykrsler klppscmigg iketqgkhvi lsgstevisn eggrfcypef ssgeeseedv
      241 lfsnmeeehe swdesdeell ameirmrgqp rfanfrantl spvrffvdkk wntiplrnks
      301 lqricavdyd dsydeilngy eensvvsygq gsiqsmvssd stspdsslte esrsetassl
      361 sqkicnggls pgnpgdskdm keiepnyesp ssnnqdkdss qaskssikvp ethkavlalr
      421 leekdgkiav qtekeeskas tdvagqavti nlvpteeqak pyrvvnleqp lckpytvvdv
      481 saamasehle gpvnspktks ssstpnspvt sssltpgqis ahfqkssair yqevwtssts
      541 prqkipkvel itsgtgpnvp prknchksap tsptatniss ktipvkspnl seikfnsynn
      601 agmppfpiii hdeptyarss knaikvpivi npnaydnlai yksflgtsge lsvkekttsv
      661 ishtyeeiet eskvpdntts kttdclqtkg fsnstehkrg svaqkvqefn nclnrgqssp
      721 qrsyssshss pakiqratqe pvakiegtqe sqmvgssstr ekastvlsqi vasiqppqsp
      781 petpqsgpka csveelyaip pdadvakstp kstpvrpksl ftsqpsgeae apqttdsptt
      841 kvqkdpsikp vtpspsklvt spqseppapf ppprstsspy hagnllqrhf tnwtkptspt
      901 rsteaesvlh segsrraada kpkrwisfks ffrrrktdee ddkekerekg klvgldgtvi
      961 hmlppppvqr hhwfteakge ssekpaivfm yrcdpaqgql svdqskartd qaavmekgra
     1021 enallqdsek krshsspsqi pkkilr
//
LOCUS       XP_011520344             710 aa            linear   PRI 05-AUG-2025
DEFINITION  inactive tyrosine-protein kinase PEAK1 isoform X4 [Homo sapiens].
ACCESSION   XP_011520344
VERSION     XP_011520344.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522042.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..710
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..710
                     /product="inactive tyrosine-protein kinase PEAK1 isoform
                     X4"
                     /calculated_mol_wt=79285
     Region          <465..628
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..710
                     /gene="PEAK1"
                     /gene_synonym="SGK269"
                     /coded_by="XM_011522042.3:134..2266"
                     /db_xref="GeneID:79834"
                     /db_xref="HGNC:HGNC:29431"
                     /db_xref="MIM:614248"
ORIGIN      
        1 mgncvsehsg hmthevtedf sprdprtvvg kqdgrgctsv ttalslpele redgkedisd
       61 pmdpnpcsat ysnlgqsraa mippkqprqp kgavddaiaf ggktdqeapn asqptppplp
      121 kkmiirante piskdlqksm esslcvmanp tydidpnwda ssagssisye lkgldiesyd
      181 slerplrker pvpsaansis slttlsikdr fsnsmeslss rrgpscrqgr giqkpqrqal
      241 yrglenreev vgkirslhtd alkklavkce dlfmagqkdq lrfgvdswsd frltsdkpcc
      301 eagdavyyta syakdplnny avkickskak esqqyyhsla vrqslavhfn iqqdcghfla
      361 evpnrllpwe dpddpekded dmeeteedak getdgknpkp cseaassqke nqgvmskkqr
      421 shvvvitrev pcltvadfvr dslaqhgksp dlyerqvcll llqlcsgleh lkpyhvthcd
      481 lrlenlllvh yqpggtaqgf gpaepsptss yptrlivsnf sqakqkshlv dpeilrdqsr
      541 lapeiitatq ykkcdefqtg iliyemlhlp npfdenpelk ereytradlp ripfrspysr
      601 glqqlascll npnpserili sdakgilqcl lwgpredlfq tftacpslvq rntllqnwld
      661 ikrtllmikf aeksldregg isledwlcaq ylafattdsl scivkilqhr
//
LOCUS       XP_005254734             174 aa            linear   PRI 05-AUG-2025
DEFINITION  sorting nexin-22 isoform X1 [Homo sapiens].
ACCESSION   XP_005254734
VERSION     XP_005254734.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254677.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..174
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..174
                     /product="sorting nexin-22 isoform X1"
                     /calculated_mol_wt=19246
     Region          2..88
                     /region_name="PX_domain"
                     /note="The Phox Homology domain, a phosphoinositide
                     binding module; cl02563"
                     /db_xref="CDD:470617"
     Site            order(23..24,38..39,51)
                     /site_type="other"
                     /note="phosphoinositide binding site [chemical binding]"
                     /db_xref="CDD:132790"
     CDS             1..174
                     /gene="SNX22"
                     /coded_by="XM_005254677.4:46..570"
                     /db_xref="GeneID:79856"
                     /db_xref="HGNC:HGNC:16315"
ORIGIN      
        1 mlevhipsvg peaegprqsp ekshmikkly kvpdfpskrl pnwrtrgleq rrqgleayiq
       61 gilylnqevp kelleflrlr hfptdpkasn wgtlreflpg dsssqqhqrp vlsfhvdpyv
      121 cnpspgeevp rygatglgcg lcisrllgps dsisfllpts gattscscpl epal
//
LOCUS       XP_016878070             165 aa            linear   PRI 05-AUG-2025
DEFINITION  sorting nexin-22 isoform X2 [Homo sapiens].
ACCESSION   XP_016878070
VERSION     XP_016878070.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022581.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..165
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..165
                     /product="sorting nexin-22 isoform X2"
                     /calculated_mol_wt=18518
     Region          2..88
                     /region_name="PX_domain"
                     /note="The Phox Homology domain, a phosphoinositide
                     binding module; cl02563"
                     /db_xref="CDD:470617"
     Site            order(23..24,38..39,51)
                     /site_type="other"
                     /note="phosphoinositide binding site [chemical binding]"
                     /db_xref="CDD:132790"
     CDS             1..165
                     /gene="SNX22"
                     /coded_by="XM_017022581.2:46..543"
                     /db_xref="GeneID:79856"
                     /db_xref="HGNC:HGNC:16315"
ORIGIN      
        1 mlevhipsvg peaegprqsp ekshmikkly kvpdfpskrl pnwrtrgleq rrqgleayiq
       61 gilylnqevp kelleflrlr hfptdpkasn wgtlreflpg dsssqqhqrp vlsfhvdpyv
      121 cnpspeslpn vvvngvlqgl ysfsispdka qpkaachpap lppmp
//
LOCUS       XP_047289036            1018 aa            linear   PRI 05-AUG-2025
DEFINITION  thrombospondin type-1 domain-containing protein 4 isoform X1 [Homo
            sapiens].
ACCESSION   XP_047289036
VERSION     XP_047289036.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433080.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1018
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1018
                     /product="thrombospondin type-1 domain-containing protein
                     4 isoform X1"
                     /calculated_mol_wt=112320
     Region          58..>95
                     /region_name="TSP1"
                     /note="Thrombospondin type 1 repeats; smart00209"
                     /db_xref="CDD:214559"
     Region          317..411
                     /region_name="ADAMTS_CR_3"
                     /note="ADAMTS cysteine-rich domain; pfam19236"
                     /db_xref="CDD:437068"
     Region          413..528
                     /region_name="ADAMTS_spacer1"
                     /note="ADAM-TS Spacer 1; pfam05986"
                     /db_xref="CDD:461796"
     Region          627..676
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          680..736
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          739..793
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          797..850
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          856..912
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          916..967
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          975..1005
                     /region_name="PLAC"
                     /note="PLAC (protease and lacunin) domain; pfam08686"
                     /db_xref="CDD:462560"
     CDS             1..1018
                     /gene="THSD4"
                     /gene_synonym="AAT12; ADAMTSL-6; ADAMTSL6; FVSY9334;
                     PRO34005"
                     /coded_by="XM_047433080.1:99..3155"
                     /db_xref="GeneID:79875"
                     /db_xref="HGNC:HGNC:25835"
                     /db_xref="MIM:614476"
ORIGIN      
        1 mvshfmgsls vlcfllllgf qfvcpqpstq hrkvpqrmaa egapeddggg gapgvwgawg
       61 pwsacsrscs ggvmeqtrpc lprsyrlrgg qrpgaparaf adhvvsavrt svplhrsrde
      121 tpalagtdas rqgptvlrgs rhpqpqglev tgdrrsrtrg tigpgkygyg kapyilplqt
      181 dtahtpqrlr rqklssrhsr sqgassarhg ysspahqvpq hgplyqsdsg prsglqaaea
      241 piyqlplthd qgypaasslf hspetsnnhg vgthgatqsf sqparstais cigayrqykl
      301 cntnvcpess rsirevqcas ynnkpfmgrf yewepfaevk gnrkcelncq amgyrfyvrq
      361 aekvidgtpc dqngtaicvs gqcksigcdd ylgsdkvvdk cgvcggdntg cqvvsgvfkh
      421 altslgyhrv veipegatki nitemyksnn ylalrsrsgr siingnwaid rpgkyegggt
      481 mftykrpnei sstagesfla egptneildv ymihqqpnpg vhyeyvimgt naispqvpph
      541 rrpgepfngq mvtegrsqee geqkgrneek edlrgeapem ftsesaqtfp vrhpdrfsph
      601 rpdnlvppap qpprrsrdhn wkqlgttecs ttcgkgsqyp ifrcvhrsth eeapesycds
      661 smkptpeeep cnifpcpafw digewsecsk tcglgmqhrq vlcrqvyanr sltvqpyrcq
      721 hlekpettst cqlkicsewq irtdwtscsv pcgvgqrtrd vkcvsnigdv vddeecnmkl
      781 rpndiencdm gpcakswflt ewsercsaec gagvrtrsvv cmtnhvsslp legcgnnrpa
      841 eatpcdngpc tgkvewfags wsqcsiecgs gtqqrevicv rknadtfevl dpsecsflek
      901 ppsqqschlk pcgakwfste wsmcskscqg gfrvrevrcl sddmtlsnlc dpqlkpeere
      961 scnpqdcvpe vdenckdkyy ncnvvvqarl cvynyyktac casctrvanr qtgflgsr
//
LOCUS       XP_016878071             724 aa            linear   PRI 05-AUG-2025
DEFINITION  thrombospondin type-1 domain-containing protein 4 isoform X2 [Homo
            sapiens].
ACCESSION   XP_016878071
VERSION     XP_016878071.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022582.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..724
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..724
                     /product="thrombospondin type-1 domain-containing protein
                     4 isoform X2"
                     /calculated_mol_wt=80266
     Region          <90..117
                     /region_name="ADAMTS_CR_3"
                     /note="ADAMTS cysteine-rich domain; pfam19236"
                     /db_xref="CDD:437068"
     Region          119..234
                     /region_name="ADAMTS_spacer1"
                     /note="ADAM-TS Spacer 1; pfam05986"
                     /db_xref="CDD:461796"
     Region          333..382
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          386..442
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          445..499
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          503..556
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          562..618
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          622..673
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          681..711
                     /region_name="PLAC"
                     /note="PLAC (protease and lacunin) domain; pfam08686"
                     /db_xref="CDD:462560"
     CDS             1..724
                     /gene="THSD4"
                     /gene_synonym="AAT12; ADAMTSL-6; ADAMTSL6; FVSY9334;
                     PRO34005"
                     /coded_by="XM_017022582.3:106..2280"
                     /db_xref="GeneID:79875"
                     /db_xref="HGNC:HGNC:25835"
                     /db_xref="MIM:614476"
ORIGIN      
        1 mikatlqlqv sftaqkqatt tvwgpmgqlr aslslpdlqq shasgpigst scatptyvqk
       61 avevsgrysv hptttshswa gfmsgnhlqk sigcddylgs dkvvdkcgvc ggdntgcqvv
      121 sgvfkhalts lgyhrvveip egatkinite myksnnylal rsrsgrsiin gnwaidrpgk
      181 yegggtmfty krpneissta gesflaegpt neildvymih qqpnpgvhye yvimgtnais
      241 pqvpphrrpg epfngqmvte grsqeegeqk grneekedlr geapemftse saqtfpvrhp
      301 drfsphrpdn lvppapqppr rsrdhnwkql gttecsttcg kgsqypifrc vhrstheeap
      361 esycdssmkp tpeeepcnif pcpafwdige wsecsktcgl gmqhrqvlcr qvyanrsltv
      421 qpyrcqhlek pettstcqlk icsewqirtd wtscsvpcgv gqrtrdvkcv snigdvvdde
      481 ecnmklrpnd iencdmgpca kswfltewse rcsaecgagv rtrsvvcmtn hvsslplegc
      541 gnnrpaeatp cdngpctgkv ewfagswsqc siecgsgtqq revicvrkna dtfevldpse
      601 csflekppsq qschlkpcga kwfstewsmc skscqggfrv revrclsddm tlsnlcdpql
      661 kpeerescnp qdcvpevden ckdkyyncnv vvqarlcvyn yyktaccasc trvanrqtgf
      721 lgsr
//
LOCUS       XP_011520345             696 aa            linear   PRI 05-AUG-2025
DEFINITION  thrombospondin type-1 domain-containing protein 4 isoform X3 [Homo
            sapiens].
ACCESSION   XP_011520345
VERSION     XP_011520345.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522043.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..696
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..696
                     /product="thrombospondin type-1 domain-containing protein
                     4 isoform X3"
                     /calculated_mol_wt=77952
     Region          91..206
                     /region_name="ADAMTS_spacer1"
                     /note="ADAM-TS Spacer 1; pfam05986"
                     /db_xref="CDD:461796"
     Region          305..354
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          358..414
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          417..471
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          475..528
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          534..590
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          594..645
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          653..683
                     /region_name="PLAC"
                     /note="PLAC (protease and lacunin) domain; pfam08686"
                     /db_xref="CDD:462560"
     CDS             1..696
                     /gene="THSD4"
                     /gene_synonym="AAT12; ADAMTSL-6; ADAMTSL6; FVSY9334;
                     PRO34005"
                     /coded_by="XM_011522043.4:1812..3902"
                     /db_xref="GeneID:79875"
                     /db_xref="HGNC:HGNC:25835"
                     /db_xref="MIM:614476"
ORIGIN      
        1 meekehvlrl qkgkgelshc waedcqnrcl cegelnvpsl isvfyssilr repqeedvql
       61 iwsigcddyl gsdkvvdkcg vcggdntgcq vvsgvfkhal tslgyhrvve ipegatkini
      121 temyksnnyl alrsrsgrsi ingnwaidrp gkyegggtmf tykrpneiss tagesflaeg
      181 ptneildvym ihqqpnpgvh yeyvimgtna ispqvpphrr pgepfngqmv tegrsqeege
      241 qkgrneeked lrgeapemft sesaqtfpvr hpdrfsphrp dnlvppapqp prrsrdhnwk
      301 qlgttecstt cgkgsqypif rcvhrsthee apesycdssm kptpeeepcn ifpcpafwdi
      361 gewsecsktc glgmqhrqvl crqvyanrsl tvqpyrcqhl ekpettstcq lkicsewqir
      421 tdwtscsvpc gvgqrtrdvk cvsnigdvvd deecnmklrp ndiencdmgp cakswfltew
      481 sercsaecga gvrtrsvvcm tnhvsslple gcgnnrpaea tpcdngpctg kvewfagsws
      541 qcsiecgsgt qqrevicvrk nadtfevldp secsflekpp sqqschlkpc gakwfstews
      601 mcskscqggf rvrevrclsd dmtlsnlcdp qlkpeeresc npqdcvpevd enckdkyync
      661 nvvvqarlcv ynyyktacca sctrvanrqt gflgsr
//
LOCUS       XP_011520346             682 aa            linear   PRI 05-AUG-2025
DEFINITION  thrombospondin type-1 domain-containing protein 4 isoform X4 [Homo
            sapiens].
ACCESSION   XP_011520346
VERSION     XP_011520346.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522044.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..682
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..682
                     /product="thrombospondin type-1 domain-containing protein
                     4 isoform X4"
                     /calculated_mol_wt=76027
     Region          <2..75
                     /region_name="ADAMTS_CR_3"
                     /note="ADAMTS cysteine-rich domain; pfam19236"
                     /db_xref="CDD:437068"
     Region          77..192
                     /region_name="ADAMTS_spacer1"
                     /note="ADAM-TS Spacer 1; pfam05986"
                     /db_xref="CDD:461796"
     Region          291..340
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          344..400
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          403..457
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          461..514
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          520..576
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          580..631
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          639..669
                     /region_name="PLAC"
                     /note="PLAC (protease and lacunin) domain; pfam08686"
                     /db_xref="CDD:462560"
     CDS             1..682
                     /gene="THSD4"
                     /gene_synonym="AAT12; ADAMTSL-6; ADAMTSL6; FVSY9334;
                     PRO34005"
                     /coded_by="XM_011522044.3:466..2514"
                     /db_xref="GeneID:79875"
                     /db_xref="HGNC:HGNC:25835"
                     /db_xref="MIM:614476"
ORIGIN      
        1 myvkgnrkce lncqamgyrf yvrqaekvid gtpcdqngta icvsgqcksi gcddylgsdk
       61 vvdkcgvcgg dntgcqvvsg vfkhaltslg yhrvveipeg atkinitemy ksnnylalrs
      121 rsgrsiingn waidrpgkye gggtmftykr pneisstage sflaegptne ildvymihqq
      181 pnpgvhyeyv imgtnaispq vpphrrpgep fngqmvtegr sqeegeqkgr neekedlrge
      241 apemftsesa qtfpvrhpdr fsphrpdnlv ppapqpprrs rdhnwkqlgt tecsttcgkg
      301 sqypifrcvh rstheeapes ycdssmkptp eeepcnifpc pafwdigews ecsktcglgm
      361 qhrqvlcrqv yanrsltvqp yrcqhlekpe ttstcqlkic sewqirtdwt scsvpcgvgq
      421 rtrdvkcvsn igdvvddeec nmklrpndie ncdmgpcaks wfltewserc saecgagvrt
      481 rsvvcmtnhv sslplegcgn nrpaeatpcd ngpctgkvew fagswsqcsi ecgsgtqqre
      541 vicvrknadt fevldpsecs flekppsqqs chlkpcgakw fstewsmcsk scqggfrvre
      601 vrclsddmtl snlcdpqlkp eerescnpqd cvpevdenck dkyyncnvvv qarlcvynyy
      661 ktaccasctr vanrqtgflg sr
//
LOCUS       XP_016878073             676 aa            linear   PRI 05-AUG-2025
DEFINITION  thrombospondin type-1 domain-containing protein 4 isoform X5 [Homo
            sapiens].
ACCESSION   XP_016878073
VERSION     XP_016878073.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022584.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..676
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..676
                     /product="thrombospondin type-1 domain-containing protein
                     4 isoform X5"
                     /calculated_mol_wt=75399
     Region          71..186
                     /region_name="ADAMTS_spacer1"
                     /note="ADAM-TS Spacer 1; pfam05986"
                     /db_xref="CDD:461796"
     Region          285..334
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          338..394
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          397..451
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          455..508
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          514..570
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          574..625
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          633..663
                     /region_name="PLAC"
                     /note="PLAC (protease and lacunin) domain; pfam08686"
                     /db_xref="CDD:462560"
     CDS             1..676
                     /gene="THSD4"
                     /gene_synonym="AAT12; ADAMTSL-6; ADAMTSL6; FVSY9334;
                     PRO34005"
                     /coded_by="XM_017022584.2:175..2205"
                     /db_xref="GeneID:79875"
                     /db_xref="HGNC:HGNC:25835"
                     /db_xref="MIM:614476"
ORIGIN      
        1 mfvsyliltl lhvqtavlar pggeeelqsh istgidmerh eqsigcddyl gsdkvvdkcg
       61 vcggdntgcq vvsgvfkhal tslgyhrvve ipegatkini temyksnnyl alrsrsgrsi
      121 ingnwaidrp gkyegggtmf tykrpneiss tagesflaeg ptneildvym ihqqpnpgvh
      181 yeyvimgtna ispqvpphrr pgepfngqmv tegrsqeege qkgrneeked lrgeapemft
      241 sesaqtfpvr hpdrfsphrp dnlvppapqp prrsrdhnwk qlgttecstt cgkgsqypif
      301 rcvhrsthee apesycdssm kptpeeepcn ifpcpafwdi gewsecsktc glgmqhrqvl
      361 crqvyanrsl tvqpyrcqhl ekpettstcq lkicsewqir tdwtscsvpc gvgqrtrdvk
      421 cvsnigdvvd deecnmklrp ndiencdmgp cakswfltew sercsaecga gvrtrsvvcm
      481 tnhvsslple gcgnnrpaea tpcdngpctg kvewfagsws qcsiecgsgt qqrevicvrk
      541 nadtfevldp secsflekpp sqqschlkpc gakwfstews mcskscqggf rvrevrclsd
      601 dmtlsnlcdp qlkpeeresc npqdcvpevd enckdkyync nvvvqarlcv ynyyktacca
      661 sctrvanrqt gflgsr
//
LOCUS       XP_016878074             674 aa            linear   PRI 05-AUG-2025
DEFINITION  thrombospondin type-1 domain-containing protein 4 isoform X6 [Homo
            sapiens].
ACCESSION   XP_016878074
VERSION     XP_016878074.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022585.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..674
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..674
                     /product="thrombospondin type-1 domain-containing protein
                     4 isoform X6"
                     /calculated_mol_wt=75142
     Region          <40..67
                     /region_name="ADAMTS_CR_3"
                     /note="ADAMTS cysteine-rich domain; pfam19236"
                     /db_xref="CDD:437068"
     Region          69..184
                     /region_name="ADAMTS_spacer1"
                     /note="ADAM-TS Spacer 1; pfam05986"
                     /db_xref="CDD:461796"
     Region          283..332
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          336..392
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          395..449
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          453..506
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          512..568
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          572..623
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          631..661
                     /region_name="PLAC"
                     /note="PLAC (protease and lacunin) domain; pfam08686"
                     /db_xref="CDD:462560"
     CDS             1..674
                     /gene="THSD4"
                     /gene_synonym="AAT12; ADAMTSL-6; ADAMTSL6; FVSY9334;
                     PRO34005"
                     /coded_by="XM_017022585.2:89..2113"
                     /db_xref="GeneID:79875"
                     /db_xref="HGNC:HGNC:25835"
                     /db_xref="MIM:614476"
ORIGIN      
        1 mndpimyvqk avevsgrysv hptttshswa gfmsgnhlqk sigcddylgs dkvvdkcgvc
       61 ggdntgcqvv sgvfkhalts lgyhrvveip egatkinite myksnnylal rsrsgrsiin
      121 gnwaidrpgk yegggtmfty krpneissta gesflaegpt neildvymih qqpnpgvhye
      181 yvimgtnais pqvpphrrpg epfngqmvte grsqeegeqk grneekedlr geapemftse
      241 saqtfpvrhp drfsphrpdn lvppapqppr rsrdhnwkql gttecsttcg kgsqypifrc
      301 vhrstheeap esycdssmkp tpeeepcnif pcpafwdige wsecsktcgl gmqhrqvlcr
      361 qvyanrsltv qpyrcqhlek pettstcqlk icsewqirtd wtscsvpcgv gqrtrdvkcv
      421 snigdvvdde ecnmklrpnd iencdmgpca kswfltewse rcsaecgagv rtrsvvcmtn
      481 hvsslplegc gnnrpaeatp cdngpctgkv ewfagswsqc siecgsgtqq revicvrkna
      541 dtfevldpse csflekppsq qschlkpcga kwfstewsmc skscqggfrv revrclsddm
      601 tlsnlcdpql kpeerescnp qdcvpevden ckdkyyncnv vvqarlcvyn yyktaccasc
      661 trvanrqtgf lgsr
//
LOCUS       XP_016878075             667 aa            linear   PRI 05-AUG-2025
DEFINITION  thrombospondin type-1 domain-containing protein 4 isoform X7 [Homo
            sapiens].
ACCESSION   XP_016878075
VERSION     XP_016878075.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022586.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..667
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..667
                     /product="thrombospondin type-1 domain-containing protein
                     4 isoform X7"
                     /calculated_mol_wt=74288
     Region          <1..60
                     /region_name="ADAMTS_CR_3"
                     /note="ADAMTS cysteine-rich domain; pfam19236"
                     /db_xref="CDD:437068"
     Region          62..177
                     /region_name="ADAMTS_spacer1"
                     /note="ADAM-TS Spacer 1; pfam05986"
                     /db_xref="CDD:461796"
     Region          276..325
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          329..385
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          388..442
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          446..499
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          505..561
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          565..616
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:465950"
     Region          624..654
                     /region_name="PLAC"
                     /note="PLAC (protease and lacunin) domain; pfam08686"
                     /db_xref="CDD:462560"
     CDS             1..667
                     /gene="THSD4"
                     /gene_synonym="AAT12; ADAMTSL-6; ADAMTSL6; FVSY9334;
                     PRO34005"
                     /coded_by="XM_017022586.2:327..2330"
                     /db_xref="GeneID:79875"
                     /db_xref="HGNC:HGNC:25835"
                     /db_xref="MIM:614476"
ORIGIN      
        1 mgyrfyvrqa ekvidgtpcd qngtaicvsg qcksigcddy lgsdkvvdkc gvcggdntgc
       61 qvvsgvfkha ltslgyhrvv eipegatkin itemyksnny lalrsrsgrs iingnwaidr
      121 pgkyegggtm ftykrpneis stagesflae gptneildvy mihqqpnpgv hyeyvimgtn
      181 aispqvpphr rpgepfngqm vtegrsqeeg eqkgrneeke dlrgeapemf tsesaqtfpv
      241 rhpdrfsphr pdnlvppapq pprrsrdhnw kqlgttecst tcgkgsqypi frcvhrsthe
      301 eapesycdss mkptpeeepc nifpcpafwd igewsecskt cglgmqhrqv lcrqvyanrs
      361 ltvqpyrcqh lekpettstc qlkicsewqi rtdwtscsvp cgvgqrtrdv kcvsnigdvv
      421 ddeecnmklr pndiencdmg pcakswflte wsercsaecg agvrtrsvvc mtnhvsslpl
      481 egcgnnrpae atpcdngpct gkvewfagsw sqcsiecgsg tqqrevicvr knadtfevld
      541 psecsflekp psqqschlkp cgakwfstew smcskscqgg frvrevrcls ddmtlsnlcd
      601 pqlkpeeres cnpqdcvpev denckdkyyn cnvvvqarlc vynyyktacc asctrvanrq
      661 tgflgsr
//
LOCUS       XP_011520348            1257 aa            linear   PRI 05-AUG-2025
DEFINITION  putative phospholipid-transporting ATPase IM isoform X1 [Homo
            sapiens].
ACCESSION   XP_011520348
VERSION     XP_011520348.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522046.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1257
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1257
                     /product="putative phospholipid-transporting ATPase IM
                     isoform X1"
                     /calculated_mol_wt=142847
     Region          67..1038
                     /region_name="P-type_ATPase_APLT_Dnf-like"
                     /note="Aminophospholipid translocases (APLTs), similar to
                     Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2,
                     -10D, -11B, -11C; cd02073"
                     /db_xref="CDD:319770"
     Site            order(457..459,602,625..627,692,739..741,854,857,860,880,
                     883)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:319770"
     CDS             1..1257
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /coded_by="XM_011522046.3:206..3979"
                     /db_xref="GeneID:79895"
                     /db_xref="HGNC:HGNC:13536"
                     /db_xref="MIM:609123"
ORIGIN      
        1 mkddffftlt tfrggasvsg gisvghllrp gersgiimfc sekklrever ivkandreyn
       61 ekfqyadnri htskyniltf lpinlfeqfq rvanayflcl lilqlipeis sltwfttivp
      121 lvlvitmtav kdatddyfrh ksdnqvnnrq sevlinsklq nekwmnvkvg diiklennqf
      181 vaadllllss sephglcyve taeldgslcc ykdvpwvecq lfgaqealpt flkqetnlkv
      241 rhalsvtsel gadisrlagf dgivvcevpn nkldkfmgil swkdskhsln nekiilrgci
      301 lrntswcfgm vifagpdtkl mqnsgktkfk rtsidrlmnt lvlwifgfli clgiilaign
      361 siwesqtgdq frtflfwneg ekssvfsgfl tfwsyiiiln tvvpislyvs vevirlghsy
      421 finwdrkmyy srkaipavar tttlneelgq ieyifsdktg tltqnimtfk rcsingriyg
      481 evhddldqkt eitqekepvd fsvksqadre fqffdhhlme sikmgdpkvh eflrllalch
      541 tvmseensag eliyqvqspd egalvtaarn fgfifksrtp etitieelgt lvtyqllafl
      601 dfnntrkrms vivrnpegqi klyskgadti lfeklhpsne vllsltsdhl sefageglrt
      661 laiayrdldd kyfkewhkml edanaateer deriaglyee ierdlmllga tavedklqeg
      721 vietvtslsl anikiwvltg dkqetainig yacnmltddm ndvfviagnn avevreelrk
      781 akqnlfgqnr nfsnghvvce kkqqleldsi veetitgdya liinghslah alesdvkndl
      841 lelacmcktv iccrvtplqk aqvvelvkky rnavtlaigd gandvsmiks ahigvgisgq
      901 eglqavlasd ysfaqfrylq rlllvhgrws yfrmckflcy ffyknfaftl vhfwfgffcg
      961 fsaqtvydqw fitlfnivyt slpvlamgif dqdvsdqnsv dcpqlykpgq lnllfnkrkf
     1021 ficvlhgiyt slvlffipyg afynvagedg qhiadyqsfa vtmatslviv vsvqialdts
     1081 ywtfinhvfi wgsiaiyfsi lftmhsngif gifpnqfpfv gnarhsltqk ciwlvilltt
     1141 vasvmpvvaf rflkvdlypt lsdqirrwqk aqkkarppss rrprtrrsss rrsgyafahq
     1201 egygelitsg knmraknppp tsglekthyn stswienlck kttdtvssfs qdktvkl
//
LOCUS       XP_024305833            1229 aa            linear   PRI 05-AUG-2025
DEFINITION  putative phospholipid-transporting ATPase IM isoform X2 [Homo
            sapiens].
ACCESSION   XP_024305833
VERSION     XP_024305833.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024450065.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1229
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1229
                     /product="putative phospholipid-transporting ATPase IM
                     isoform X2"
                     /calculated_mol_wt=139647
     Region          67..1010
                     /region_name="P-type_ATPase_APLT_Dnf-like"
                     /note="Aminophospholipid translocases (APLTs), similar to
                     Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2,
                     -10D, -11B, -11C; cd02073"
                     /db_xref="CDD:319770"
     Site            order(429..431,574,597..599,664,711..713,826,829,832,852,
                     855)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:319770"
     CDS             1..1229
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /coded_by="XM_024450065.2:206..3895"
                     /db_xref="GeneID:79895"
                     /db_xref="HGNC:HGNC:13536"
                     /db_xref="MIM:609123"
ORIGIN      
        1 mkddffftlt tfrggasvsg gisvghllrp gersgiimfc sekklrever ivkandreyn
       61 ekfqyadnri htskyniltf lpinlfeqfq rvanayflcl lilqlipeis sltwfttivp
      121 lvlvitmtav kdatddyfrh ksdnqvnnrq sevlinsklq nekwmnvkvg diiklennqf
      181 vaadllllss sephglcyve taeldgetnl kvrhalsvts elgadisrla gfdgivvcev
      241 pnnkldkfmg ilswkdskhs lnnekiilrg cilrntswcf gmvifagpdt klmqnsgktk
      301 fkrtsidrlm ntlvlwifgf liclgiilai gnsiwesqtg dqfrtflfwn egekssvfsg
      361 fltfwsyiii lntvvpisly vsvevirlgh syfinwdrkm yysrkaipav artttlneel
      421 gqieyifsdk tgtltqnimt fkrcsingri ygevhddldq kteitqekep vdfsvksqad
      481 refqffdhhl mesikmgdpk vheflrllal chtvmseens ageliyqvqs pdegalvtaa
      541 rnfgfifksr tpetitieel gtlvtyqlla fldfnntrkr msvivrnpeg qiklyskgad
      601 tilfeklhps nevllsltsd hlsefagegl rtlaiayrdl ddkyfkewhk mledanaate
      661 erderiagly eeierdlmll gatavedklq egvietvtsl slanikiwvl tgdkqetain
      721 igyacnmltd dmndvfviag nnavevreel rkakqnlfgq nrnfsnghvv cekkqqleld
      781 siveetitgd yaliinghsl ahalesdvkn dllelacmck tviccrvtpl qkaqvvelvk
      841 kyrnavtlai gdgandvsmi ksahigvgis gqeglqavla sdysfaqfry lqrlllvhgr
      901 wsyfrmckfl cyffyknfaf tlvhfwfgff cgfsaqtvyd qwfitlfniv ytslpvlamg
      961 ifdqdvsdqn svdcpqlykp gqlnllfnkr kfficvlhgi ytslvlffip ygafynvage
     1021 dgqhiadyqs favtmatslv ivvsvqiald tsywtfinhv fiwgsiaiyf silftmhsng
     1081 ifgifpnqfp fvgnarhslt qkciwlvill ttvasvmpvv afrflkvdly ptlsdqirrw
     1141 qkaqkkarpp ssrrprtrrs ssrrsgyafa hqegygelit sgknmraknp pptsglekth
     1201 ynstswienl ckkttdtvss fsqdktvkl
//
LOCUS       XP_011520349            1220 aa            linear   PRI 05-AUG-2025
DEFINITION  putative phospholipid-transporting ATPase IM isoform X3 [Homo
            sapiens].
ACCESSION   XP_011520349
VERSION     XP_011520349.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522047.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1220
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1220
                     /product="putative phospholipid-transporting ATPase IM
                     isoform X3"
                     /calculated_mol_wt=138937
     Region          30..1001
                     /region_name="P-type_ATPase_APLT_Dnf-like"
                     /note="Aminophospholipid translocases (APLTs), similar to
                     Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2,
                     -10D, -11B, -11C; cd02073"
                     /db_xref="CDD:319770"
     Site            order(420..422,565,588..590,655,702..704,817,820,823,843,
                     846)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:319770"
     CDS             1..1220
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /coded_by="XM_011522047.3:110..3772"
                     /db_xref="GeneID:79895"
                     /db_xref="HGNC:HGNC:13536"
                     /db_xref="MIM:609123"
ORIGIN      
        1 mfcsekklre verivkandr eynekfqyad nrihtskyni ltflpinlfe qfqrvanayf
       61 lcllilqlip eissltwftt ivplvlvitm tavkdatddy frhksdnqvn nrqsevlins
      121 klqnekwmnv kvgdiiklen nqfvaadlll lsssephglc yvetaeldgs lccykdvpwv
      181 ecqlfgaqea lptflkqetn lkvrhalsvt selgadisrl agfdgivvce vpnnkldkfm
      241 gilswkdskh slnnekiilr gcilrntswc fgmvifagpd tklmqnsgkt kfkrtsidrl
      301 mntlvlwifg fliclgiila ignsiwesqt gdqfrtflfw negekssvfs gfltfwsyii
      361 ilntvvpisl yvsvevirlg hsyfinwdrk myysrkaipa vartttlnee lgqieyifsd
      421 ktgtltqnim tfkrcsingr iygevhddld qkteitqeke pvdfsvksqa drefqffdhh
      481 lmesikmgdp kvheflrlla lchtvmseen sageliyqvq spdegalvta arnfgfifks
      541 rtpetitiee lgtlvtyqll afldfnntrk rmsvivrnpe gqiklyskga dtilfeklhp
      601 snevllslts dhlsefageg lrtlaiayrd lddkyfkewh kmledanaat eerderiagl
      661 yeeierdlml lgatavedkl qegvietvts lslanikiwv ltgdkqetai nigyacnmlt
      721 ddmndvfvia gnnavevree lrkakqnlfg qnrnfsnghv vcekkqqlel dsiveetitg
      781 dyaliinghs lahalesdvk ndllelacmc ktviccrvtp lqkaqvvelv kkyrnavtla
      841 igdgandvsm iksahigvgi sgqeglqavl asdysfaqfr ylqrlllvhg rwsyfrmckf
      901 lcyffyknfa ftlvhfwfgf fcgfsaqtvy dqwfitlfni vytslpvlam gifdqdvsdq
      961 nsvdcpqlyk pgqlnllfnk rkfficvlhg iytslvlffi pygafynvag edgqhiadyq
     1021 sfavtmatsl vivvsvqial dtsywtfinh vfiwgsiaiy fsilftmhsn gifgifpnqf
     1081 pfvgnarhsl tqkciwlvil lttvasvmpv vafrflkvdl yptlsdqirr wqkaqkkarp
     1141 pssrrprtrr sssrrsgyaf ahqegygeli tsgknmrakn ppptsglekt hynstswien
     1201 lckkttdtvs sfsqdktvkl
//
LOCUS       XP_011520355            1220 aa            linear   PRI 05-AUG-2025
DEFINITION  putative phospholipid-transporting ATPase IM isoform X3 [Homo
            sapiens].
ACCESSION   XP_011520355
VERSION     XP_011520355.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522053.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1220
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1220
                     /product="putative phospholipid-transporting ATPase IM
                     isoform X3"
                     /calculated_mol_wt=138937
     Region          30..1001
                     /region_name="P-type_ATPase_APLT_Dnf-like"
                     /note="Aminophospholipid translocases (APLTs), similar to
                     Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2,
                     -10D, -11B, -11C; cd02073"
                     /db_xref="CDD:319770"
     Site            order(420..422,565,588..590,655,702..704,817,820,823,843,
                     846)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:319770"
     CDS             1..1220
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /coded_by="XM_011522053.2:123..3785"
                     /db_xref="GeneID:79895"
                     /db_xref="HGNC:HGNC:13536"
                     /db_xref="MIM:609123"
ORIGIN      
        1 mfcsekklre verivkandr eynekfqyad nrihtskyni ltflpinlfe qfqrvanayf
       61 lcllilqlip eissltwftt ivplvlvitm tavkdatddy frhksdnqvn nrqsevlins
      121 klqnekwmnv kvgdiiklen nqfvaadlll lsssephglc yvetaeldgs lccykdvpwv
      181 ecqlfgaqea lptflkqetn lkvrhalsvt selgadisrl agfdgivvce vpnnkldkfm
      241 gilswkdskh slnnekiilr gcilrntswc fgmvifagpd tklmqnsgkt kfkrtsidrl
      301 mntlvlwifg fliclgiila ignsiwesqt gdqfrtflfw negekssvfs gfltfwsyii
      361 ilntvvpisl yvsvevirlg hsyfinwdrk myysrkaipa vartttlnee lgqieyifsd
      421 ktgtltqnim tfkrcsingr iygevhddld qkteitqeke pvdfsvksqa drefqffdhh
      481 lmesikmgdp kvheflrlla lchtvmseen sageliyqvq spdegalvta arnfgfifks
      541 rtpetitiee lgtlvtyqll afldfnntrk rmsvivrnpe gqiklyskga dtilfeklhp
      601 snevllslts dhlsefageg lrtlaiayrd lddkyfkewh kmledanaat eerderiagl
      661 yeeierdlml lgatavedkl qegvietvts lslanikiwv ltgdkqetai nigyacnmlt
      721 ddmndvfvia gnnavevree lrkakqnlfg qnrnfsnghv vcekkqqlel dsiveetitg
      781 dyaliinghs lahalesdvk ndllelacmc ktviccrvtp lqkaqvvelv kkyrnavtla
      841 igdgandvsm iksahigvgi sgqeglqavl asdysfaqfr ylqrlllvhg rwsyfrmckf
      901 lcyffyknfa ftlvhfwfgf fcgfsaqtvy dqwfitlfni vytslpvlam gifdqdvsdq
      961 nsvdcpqlyk pgqlnllfnk rkfficvlhg iytslvlffi pygafynvag edgqhiadyq
     1021 sfavtmatsl vivvsvqial dtsywtfinh vfiwgsiaiy fsilftmhsn gifgifpnqf
     1081 pfvgnarhsl tqkciwlvil lttvasvmpv vafrflkvdl yptlsdqirr wqkaqkkarp
     1141 pssrrprtrr sssrrsgyaf ahqegygeli tsgknmrakn ppptsglekt hynstswien
     1201 lckkttdtvs sfsqdktvkl
//
LOCUS       XP_011520351            1220 aa            linear   PRI 05-AUG-2025
DEFINITION  putative phospholipid-transporting ATPase IM isoform X3 [Homo
            sapiens].
ACCESSION   XP_011520351
VERSION     XP_011520351.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522049.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1220
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1220
                     /product="putative phospholipid-transporting ATPase IM
                     isoform X3"
                     /calculated_mol_wt=138937
     Region          30..1001
                     /region_name="P-type_ATPase_APLT_Dnf-like"
                     /note="Aminophospholipid translocases (APLTs), similar to
                     Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2,
                     -10D, -11B, -11C; cd02073"
                     /db_xref="CDD:319770"
     Site            order(420..422,565,588..590,655,702..704,817,820,823,843,
                     846)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:319770"
     CDS             1..1220
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /coded_by="XM_011522049.3:225..3887"
                     /db_xref="GeneID:79895"
                     /db_xref="HGNC:HGNC:13536"
                     /db_xref="MIM:609123"
ORIGIN      
        1 mfcsekklre verivkandr eynekfqyad nrihtskyni ltflpinlfe qfqrvanayf
       61 lcllilqlip eissltwftt ivplvlvitm tavkdatddy frhksdnqvn nrqsevlins
      121 klqnekwmnv kvgdiiklen nqfvaadlll lsssephglc yvetaeldgs lccykdvpwv
      181 ecqlfgaqea lptflkqetn lkvrhalsvt selgadisrl agfdgivvce vpnnkldkfm
      241 gilswkdskh slnnekiilr gcilrntswc fgmvifagpd tklmqnsgkt kfkrtsidrl
      301 mntlvlwifg fliclgiila ignsiwesqt gdqfrtflfw negekssvfs gfltfwsyii
      361 ilntvvpisl yvsvevirlg hsyfinwdrk myysrkaipa vartttlnee lgqieyifsd
      421 ktgtltqnim tfkrcsingr iygevhddld qkteitqeke pvdfsvksqa drefqffdhh
      481 lmesikmgdp kvheflrlla lchtvmseen sageliyqvq spdegalvta arnfgfifks
      541 rtpetitiee lgtlvtyqll afldfnntrk rmsvivrnpe gqiklyskga dtilfeklhp
      601 snevllslts dhlsefageg lrtlaiayrd lddkyfkewh kmledanaat eerderiagl
      661 yeeierdlml lgatavedkl qegvietvts lslanikiwv ltgdkqetai nigyacnmlt
      721 ddmndvfvia gnnavevree lrkakqnlfg qnrnfsnghv vcekkqqlel dsiveetitg
      781 dyaliinghs lahalesdvk ndllelacmc ktviccrvtp lqkaqvvelv kkyrnavtla
      841 igdgandvsm iksahigvgi sgqeglqavl asdysfaqfr ylqrlllvhg rwsyfrmckf
      901 lcyffyknfa ftlvhfwfgf fcgfsaqtvy dqwfitlfni vytslpvlam gifdqdvsdq
      961 nsvdcpqlyk pgqlnllfnk rkfficvlhg iytslvlffi pygafynvag edgqhiadyq
     1021 sfavtmatsl vivvsvqial dtsywtfinh vfiwgsiaiy fsilftmhsn gifgifpnqf
     1081 pfvgnarhsl tqkciwlvil lttvasvmpv vafrflkvdl yptlsdqirr wqkaqkkarp
     1141 pssrrprtrr sssrrsgyaf ahqegygeli tsgknmrakn ppptsglekt hynstswien
     1201 lckkttdtvs sfsqdktvkl
//
LOCUS       XP_011520350            1220 aa            linear   PRI 05-AUG-2025
DEFINITION  putative phospholipid-transporting ATPase IM isoform X3 [Homo
            sapiens].
ACCESSION   XP_011520350
VERSION     XP_011520350.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522048.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1220
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1220
                     /product="putative phospholipid-transporting ATPase IM
                     isoform X3"
                     /calculated_mol_wt=138937
     Region          30..1001
                     /region_name="P-type_ATPase_APLT_Dnf-like"
                     /note="Aminophospholipid translocases (APLTs), similar to
                     Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2,
                     -10D, -11B, -11C; cd02073"
                     /db_xref="CDD:319770"
     Site            order(420..422,565,588..590,655,702..704,817,820,823,843,
                     846)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:319770"
     CDS             1..1220
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /coded_by="XM_011522048.2:154..3816"
                     /db_xref="GeneID:79895"
                     /db_xref="HGNC:HGNC:13536"
                     /db_xref="MIM:609123"
ORIGIN      
        1 mfcsekklre verivkandr eynekfqyad nrihtskyni ltflpinlfe qfqrvanayf
       61 lcllilqlip eissltwftt ivplvlvitm tavkdatddy frhksdnqvn nrqsevlins
      121 klqnekwmnv kvgdiiklen nqfvaadlll lsssephglc yvetaeldgs lccykdvpwv
      181 ecqlfgaqea lptflkqetn lkvrhalsvt selgadisrl agfdgivvce vpnnkldkfm
      241 gilswkdskh slnnekiilr gcilrntswc fgmvifagpd tklmqnsgkt kfkrtsidrl
      301 mntlvlwifg fliclgiila ignsiwesqt gdqfrtflfw negekssvfs gfltfwsyii
      361 ilntvvpisl yvsvevirlg hsyfinwdrk myysrkaipa vartttlnee lgqieyifsd
      421 ktgtltqnim tfkrcsingr iygevhddld qkteitqeke pvdfsvksqa drefqffdhh
      481 lmesikmgdp kvheflrlla lchtvmseen sageliyqvq spdegalvta arnfgfifks
      541 rtpetitiee lgtlvtyqll afldfnntrk rmsvivrnpe gqiklyskga dtilfeklhp
      601 snevllslts dhlsefageg lrtlaiayrd lddkyfkewh kmledanaat eerderiagl
      661 yeeierdlml lgatavedkl qegvietvts lslanikiwv ltgdkqetai nigyacnmlt
      721 ddmndvfvia gnnavevree lrkakqnlfg qnrnfsnghv vcekkqqlel dsiveetitg
      781 dyaliinghs lahalesdvk ndllelacmc ktviccrvtp lqkaqvvelv kkyrnavtla
      841 igdgandvsm iksahigvgi sgqeglqavl asdysfaqfr ylqrlllvhg rwsyfrmckf
      901 lcyffyknfa ftlvhfwfgf fcgfsaqtvy dqwfitlfni vytslpvlam gifdqdvsdq
      961 nsvdcpqlyk pgqlnllfnk rkfficvlhg iytslvlffi pygafynvag edgqhiadyq
     1021 sfavtmatsl vivvsvqial dtsywtfinh vfiwgsiaiy fsilftmhsn gifgifpnqf
     1081 pfvgnarhsl tqkciwlvil lttvasvmpv vafrflkvdl yptlsdqirr wqkaqkkarp
     1141 pssrrprtrr sssrrsgyaf ahqegygeli tsgknmrakn ppptsglekt hynstswien
     1201 lckkttdtvs sfsqdktvkl
//
LOCUS       XP_011520354            1220 aa            linear   PRI 05-AUG-2025
DEFINITION  putative phospholipid-transporting ATPase IM isoform X3 [Homo
            sapiens].
ACCESSION   XP_011520354
VERSION     XP_011520354.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522052.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1220
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1220
                     /product="putative phospholipid-transporting ATPase IM
                     isoform X3"
                     /calculated_mol_wt=138937
     Region          30..1001
                     /region_name="P-type_ATPase_APLT_Dnf-like"
                     /note="Aminophospholipid translocases (APLTs), similar to
                     Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2,
                     -10D, -11B, -11C; cd02073"
                     /db_xref="CDD:319770"
     Site            order(420..422,565,588..590,655,702..704,817,820,823,843,
                     846)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:319770"
     CDS             1..1220
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /coded_by="XM_011522052.4:430..4092"
                     /db_xref="GeneID:79895"
                     /db_xref="HGNC:HGNC:13536"
                     /db_xref="MIM:609123"
ORIGIN      
        1 mfcsekklre verivkandr eynekfqyad nrihtskyni ltflpinlfe qfqrvanayf
       61 lcllilqlip eissltwftt ivplvlvitm tavkdatddy frhksdnqvn nrqsevlins
      121 klqnekwmnv kvgdiiklen nqfvaadlll lsssephglc yvetaeldgs lccykdvpwv
      181 ecqlfgaqea lptflkqetn lkvrhalsvt selgadisrl agfdgivvce vpnnkldkfm
      241 gilswkdskh slnnekiilr gcilrntswc fgmvifagpd tklmqnsgkt kfkrtsidrl
      301 mntlvlwifg fliclgiila ignsiwesqt gdqfrtflfw negekssvfs gfltfwsyii
      361 ilntvvpisl yvsvevirlg hsyfinwdrk myysrkaipa vartttlnee lgqieyifsd
      421 ktgtltqnim tfkrcsingr iygevhddld qkteitqeke pvdfsvksqa drefqffdhh
      481 lmesikmgdp kvheflrlla lchtvmseen sageliyqvq spdegalvta arnfgfifks
      541 rtpetitiee lgtlvtyqll afldfnntrk rmsvivrnpe gqiklyskga dtilfeklhp
      601 snevllslts dhlsefageg lrtlaiayrd lddkyfkewh kmledanaat eerderiagl
      661 yeeierdlml lgatavedkl qegvietvts lslanikiwv ltgdkqetai nigyacnmlt
      721 ddmndvfvia gnnavevree lrkakqnlfg qnrnfsnghv vcekkqqlel dsiveetitg
      781 dyaliinghs lahalesdvk ndllelacmc ktviccrvtp lqkaqvvelv kkyrnavtla
      841 igdgandvsm iksahigvgi sgqeglqavl asdysfaqfr ylqrlllvhg rwsyfrmckf
      901 lcyffyknfa ftlvhfwfgf fcgfsaqtvy dqwfitlfni vytslpvlam gifdqdvsdq
      961 nsvdcpqlyk pgqlnllfnk rkfficvlhg iytslvlffi pygafynvag edgqhiadyq
     1021 sfavtmatsl vivvsvqial dtsywtfinh vfiwgsiaiy fsilftmhsn gifgifpnqf
     1081 pfvgnarhsl tqkciwlvil lttvasvmpv vafrflkvdl yptlsdqirr wqkaqkkarp
     1141 pssrrprtrr sssrrsgyaf ahqegygeli tsgknmrakn ppptsglekt hynstswien
     1201 lckkttdtvs sfsqdktvkl
//
LOCUS       XP_047289038            1220 aa            linear   PRI 05-AUG-2025
DEFINITION  putative phospholipid-transporting ATPase IM isoform X3 [Homo
            sapiens].
ACCESSION   XP_047289038
VERSION     XP_047289038.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433082.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1220
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1220
                     /product="putative phospholipid-transporting ATPase IM
                     isoform X3"
                     /calculated_mol_wt=138937
     Region          30..1001
                     /region_name="P-type_ATPase_APLT_Dnf-like"
                     /note="Aminophospholipid translocases (APLTs), similar to
                     Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2,
                     -10D, -11B, -11C; cd02073"
                     /db_xref="CDD:319770"
     Site            order(420..422,565,588..590,655,702..704,817,820,823,843,
                     846)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:319770"
     CDS             1..1220
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /coded_by="XM_047433082.1:121..3783"
                     /db_xref="GeneID:79895"
                     /db_xref="HGNC:HGNC:13536"
                     /db_xref="MIM:609123"
ORIGIN      
        1 mfcsekklre verivkandr eynekfqyad nrihtskyni ltflpinlfe qfqrvanayf
       61 lcllilqlip eissltwftt ivplvlvitm tavkdatddy frhksdnqvn nrqsevlins
      121 klqnekwmnv kvgdiiklen nqfvaadlll lsssephglc yvetaeldgs lccykdvpwv
      181 ecqlfgaqea lptflkqetn lkvrhalsvt selgadisrl agfdgivvce vpnnkldkfm
      241 gilswkdskh slnnekiilr gcilrntswc fgmvifagpd tklmqnsgkt kfkrtsidrl
      301 mntlvlwifg fliclgiila ignsiwesqt gdqfrtflfw negekssvfs gfltfwsyii
      361 ilntvvpisl yvsvevirlg hsyfinwdrk myysrkaipa vartttlnee lgqieyifsd
      421 ktgtltqnim tfkrcsingr iygevhddld qkteitqeke pvdfsvksqa drefqffdhh
      481 lmesikmgdp kvheflrlla lchtvmseen sageliyqvq spdegalvta arnfgfifks
      541 rtpetitiee lgtlvtyqll afldfnntrk rmsvivrnpe gqiklyskga dtilfeklhp
      601 snevllslts dhlsefageg lrtlaiayrd lddkyfkewh kmledanaat eerderiagl
      661 yeeierdlml lgatavedkl qegvietvts lslanikiwv ltgdkqetai nigyacnmlt
      721 ddmndvfvia gnnavevree lrkakqnlfg qnrnfsnghv vcekkqqlel dsiveetitg
      781 dyaliinghs lahalesdvk ndllelacmc ktviccrvtp lqkaqvvelv kkyrnavtla
      841 igdgandvsm iksahigvgi sgqeglqavl asdysfaqfr ylqrlllvhg rwsyfrmckf
      901 lcyffyknfa ftlvhfwfgf fcgfsaqtvy dqwfitlfni vytslpvlam gifdqdvsdq
      961 nsvdcpqlyk pgqlnllfnk rkfficvlhg iytslvlffi pygafynvag edgqhiadyq
     1021 sfavtmatsl vivvsvqial dtsywtfinh vfiwgsiaiy fsilftmhsn gifgifpnqf
     1081 pfvgnarhsl tqkciwlvil lttvasvmpv vafrflkvdl yptlsdqirr wqkaqkkarp
     1141 pssrrprtrr sssrrsgyaf ahqegygeli tsgknmrakn ppptsglekt hynstswien
     1201 lckkttdtvs sfsqdktvkl
//
LOCUS       XP_016878080            1220 aa            linear   PRI 05-AUG-2025
DEFINITION  putative phospholipid-transporting ATPase IM isoform X3 [Homo
            sapiens].
ACCESSION   XP_016878080
VERSION     XP_016878080.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022591.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1220
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1220
                     /product="putative phospholipid-transporting ATPase IM
                     isoform X3"
                     /calculated_mol_wt=138937
     Region          30..1001
                     /region_name="P-type_ATPase_APLT_Dnf-like"
                     /note="Aminophospholipid translocases (APLTs), similar to
                     Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2,
                     -10D, -11B, -11C; cd02073"
                     /db_xref="CDD:319770"
     Site            order(420..422,565,588..590,655,702..704,817,820,823,843,
                     846)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:319770"
     CDS             1..1220
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /coded_by="XM_017022591.2:229..3891"
                     /db_xref="GeneID:79895"
                     /db_xref="HGNC:HGNC:13536"
                     /db_xref="MIM:609123"
ORIGIN      
        1 mfcsekklre verivkandr eynekfqyad nrihtskyni ltflpinlfe qfqrvanayf
       61 lcllilqlip eissltwftt ivplvlvitm tavkdatddy frhksdnqvn nrqsevlins
      121 klqnekwmnv kvgdiiklen nqfvaadlll lsssephglc yvetaeldgs lccykdvpwv
      181 ecqlfgaqea lptflkqetn lkvrhalsvt selgadisrl agfdgivvce vpnnkldkfm
      241 gilswkdskh slnnekiilr gcilrntswc fgmvifagpd tklmqnsgkt kfkrtsidrl
      301 mntlvlwifg fliclgiila ignsiwesqt gdqfrtflfw negekssvfs gfltfwsyii
      361 ilntvvpisl yvsvevirlg hsyfinwdrk myysrkaipa vartttlnee lgqieyifsd
      421 ktgtltqnim tfkrcsingr iygevhddld qkteitqeke pvdfsvksqa drefqffdhh
      481 lmesikmgdp kvheflrlla lchtvmseen sageliyqvq spdegalvta arnfgfifks
      541 rtpetitiee lgtlvtyqll afldfnntrk rmsvivrnpe gqiklyskga dtilfeklhp
      601 snevllslts dhlsefageg lrtlaiayrd lddkyfkewh kmledanaat eerderiagl
      661 yeeierdlml lgatavedkl qegvietvts lslanikiwv ltgdkqetai nigyacnmlt
      721 ddmndvfvia gnnavevree lrkakqnlfg qnrnfsnghv vcekkqqlel dsiveetitg
      781 dyaliinghs lahalesdvk ndllelacmc ktviccrvtp lqkaqvvelv kkyrnavtla
      841 igdgandvsm iksahigvgi sgqeglqavl asdysfaqfr ylqrlllvhg rwsyfrmckf
      901 lcyffyknfa ftlvhfwfgf fcgfsaqtvy dqwfitlfni vytslpvlam gifdqdvsdq
      961 nsvdcpqlyk pgqlnllfnk rkfficvlhg iytslvlffi pygafynvag edgqhiadyq
     1021 sfavtmatsl vivvsvqial dtsywtfinh vfiwgsiaiy fsilftmhsn gifgifpnqf
     1081 pfvgnarhsl tqkciwlvil lttvasvmpv vafrflkvdl yptlsdqirr wqkaqkkarp
     1141 pssrrprtrr sssrrsgyaf ahqegygeli tsgknmrakn ppptsglekt hynstswien
     1201 lckkttdtvs sfsqdktvkl
//
LOCUS       XP_024305834            1204 aa            linear   PRI 05-AUG-2025
DEFINITION  putative phospholipid-transporting ATPase IM isoform X4 [Homo
            sapiens].
ACCESSION   XP_024305834
VERSION     XP_024305834.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024450066.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1204
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1204
                     /product="putative phospholipid-transporting ATPase IM
                     isoform X4"
                     /calculated_mol_wt=136825
     Region          67..985
                     /region_name="P-type_ATPase_APLT_Dnf-like"
                     /note="Aminophospholipid translocases (APLTs), similar to
                     Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2,
                     -10D, -11B, -11C; cd02073"
                     /db_xref="CDD:319770"
     Site            order(404..406,549,572..574,639,686..688,801,804,807,827,
                     830)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:319770"
     CDS             1..1204
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /coded_by="XM_024450066.2:206..3820"
                     /db_xref="GeneID:79895"
                     /db_xref="HGNC:HGNC:13536"
                     /db_xref="MIM:609123"
ORIGIN      
        1 mkddffftlt tfrggasvsg gisvghllrp gersgiimfc sekklrever ivkandreyn
       61 ekfqyadnri htskyniltf lpinlfeqfq rvanayflcl lilqlipeis sltwfttivp
      121 lvlvitmtav kdatddyfrh ksdnqvnnrq sevlinsklq nekwmnvkvg diiklennqf
      181 vaadllllss sephglcyve taeldgslcc ykdvpwvecq lfgaqealpt flkqetnlkv
      241 rhalsvtsel gadisrlagf dgpdtklmqn sgktkfkrts idrlmntlvl wifgfliclg
      301 iilaignsiw esqtgdqfrt flfwnegeks svfsgfltfw syiiilntvv pislyvsvev
      361 irlghsyfin wdrkmyysrk aipavarttt lneelgqiey ifsdktgtlt qnimtfkrcs
      421 ingriygevh ddldqkteit qekepvdfsv ksqadrefqf fdhhlmesik mgdpkvhefl
      481 rllalchtvm seensageli yqvqspdega lvtaarnfgf ifksrtpeti tieelgtlvt
      541 yqllafldfn ntrkrmsviv rnpegqikly skgadtilfe klhpsnevll sltsdhlsef
      601 ageglrtlai ayrdlddkyf kewhkmleda naateerder iaglyeeier dlmllgatav
      661 edklqegvie tvtslslani kiwvltgdkq etainigyac nmltddmndv fviagnnave
      721 vreelrkakq nlfgqnrnfs nghvvcekkq qleldsivee titgdyalii nghslahale
      781 sdvkndllel acmcktvicc rvtplqkaqv velvkkyrna vtlaigdgan dvsmiksahi
      841 gvgisgqegl qavlasdysf aqfrylqrll lvhgrwsyfr mckflcyffy knfaftlvhf
      901 wfgffcgfsa qtvydqwfit lfnivytslp vlamgifdqd vsdqnsvdcp qlykpgqlnl
      961 lfnkrkffic vlhgiytslv lffipygafy nvagedgqhi adyqsfavtm atslvivvsv
     1021 qialdtsywt finhvfiwgs iaiyfsilft mhsngifgif pnqfpfvgna rhsltqkciw
     1081 lvillttvas vmpvvafrfl kvdlyptlsd qirrwqkaqk karppssrrp rtrrsssrrs
     1141 gyafahqegy gelitsgknm raknppptsg lekthynsts wienlckktt dtvssfsqdk
     1201 tvkl
//
LOCUS       XP_024305835            1194 aa            linear   PRI 05-AUG-2025
DEFINITION  putative phospholipid-transporting ATPase IM isoform X5 [Homo
            sapiens].
ACCESSION   XP_024305835
VERSION     XP_024305835.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024450067.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1194
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1194
                     /product="putative phospholipid-transporting ATPase IM
                     isoform X5"
                     /calculated_mol_wt=135740
     Region          67..975
                     /region_name="P-type_ATPase_APLT_Dnf-like"
                     /note="Aminophospholipid translocases (APLTs), similar to
                     Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2,
                     -10D, -11B, -11C; cd02073"
                     /db_xref="CDD:319770"
     Site            order(457..459,546,562..564,629,676..678,791,794,797,817,
                     820)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:319770"
     CDS             1..1194
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /coded_by="XM_024450067.2:206..3790"
                     /db_xref="GeneID:79895"
                     /db_xref="HGNC:HGNC:13536"
                     /db_xref="MIM:609123"
ORIGIN      
        1 mkddffftlt tfrggasvsg gisvghllrp gersgiimfc sekklrever ivkandreyn
       61 ekfqyadnri htskyniltf lpinlfeqfq rvanayflcl lilqlipeis sltwfttivp
      121 lvlvitmtav kdatddyfrh ksdnqvnnrq sevlinsklq nekwmnvkvg diiklennqf
      181 vaadllllss sephglcyve taeldgslcc ykdvpwvecq lfgaqealpt flkqetnlkv
      241 rhalsvtsel gadisrlagf dgivvcevpn nkldkfmgil swkdskhsln nekiilrgci
      301 lrntswcfgm vifagpdtkl mqnsgktkfk rtsidrlmnt lvlwifgfli clgiilaign
      361 siwesqtgdq frtflfwneg ekssvfsgfl tfwsyiiiln tvvpislyvs vevirlghsy
      421 finwdrkmyy srkaipavar tttlneelgq ieyifsdktg tltqnimtfk rcsingriyg
      481 evhddldqkt eitqekepvd fsvksqadre fqffdhhlme sikmgdpkvh eflrllalch
      541 tvmseensav rnpegqikly skgadtilfe klhpsnevll sltsdhlsef ageglrtlai
      601 ayrdlddkyf kewhkmleda naateerder iaglyeeier dlmllgatav edklqegvie
      661 tvtslslani kiwvltgdkq etainigyac nmltddmndv fviagnnave vreelrkakq
      721 nlfgqnrnfs nghvvcekkq qleldsivee titgdyalii nghslahale sdvkndllel
      781 acmcktvicc rvtplqkaqv velvkkyrna vtlaigdgan dvsmiksahi gvgisgqegl
      841 qavlasdysf aqfrylqrll lvhgrwsyfr mckflcyffy knfaftlvhf wfgffcgfsa
      901 qtvydqwfit lfnivytslp vlamgifdqd vsdqnsvdcp qlykpgqlnl lfnkrkffic
      961 vlhgiytslv lffipygafy nvagedgqhi adyqsfavtm atslvivvsv qialdtsywt
     1021 finhvfiwgs iaiyfsilft mhsngifgif pnqfpfvgna rhsltqkciw lvillttvas
     1081 vmpvvafrfl kvdlyptlsd qirrwqkaqk karppssrrp rtrrsssrrs gyafahqegy
     1141 gelitsgknm raknppptsg lekthynsts wienlckktt dtvssfsqdk tvkl
//
LOCUS       XP_047289039            1192 aa            linear   PRI 05-AUG-2025
DEFINITION  putative phospholipid-transporting ATPase IM isoform X6 [Homo
            sapiens].
ACCESSION   XP_047289039
VERSION     XP_047289039.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433083.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1192
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1192
                     /product="putative phospholipid-transporting ATPase IM
                     isoform X6"
                     /calculated_mol_wt=135738
     Region          30..973
                     /region_name="P-type_ATPase_APLT_Dnf-like"
                     /note="Aminophospholipid translocases (APLTs), similar to
                     Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2,
                     -10D, -11B, -11C; cd02073"
                     /db_xref="CDD:319770"
     Site            order(392..394,537,560..562,627,674..676,789,792,795,815,
                     818)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:319770"
     CDS             1..1192
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /coded_by="XM_047433083.1:110..3688"
                     /db_xref="GeneID:79895"
                     /db_xref="HGNC:HGNC:13536"
                     /db_xref="MIM:609123"
ORIGIN      
        1 mfcsekklre verivkandr eynekfqyad nrihtskyni ltflpinlfe qfqrvanayf
       61 lcllilqlip eissltwftt ivplvlvitm tavkdatddy frhksdnqvn nrqsevlins
      121 klqnekwmnv kvgdiiklen nqfvaadlll lsssephglc yvetaeldge tnlkvrhals
      181 vtselgadis rlagfdgivv cevpnnkldk fmgilswkds khslnnekii lrgcilrnts
      241 wcfgmvifag pdtklmqnsg ktkfkrtsid rlmntlvlwi fgfliclgii laignsiwes
      301 qtgdqfrtfl fwnegekssv fsgfltfwsy iiilntvvpi slyvsvevir lghsyfinwd
      361 rkmyysrkai pavartttln eelgqieyif sdktgtltqn imtfkrcsin griygevhdd
      421 ldqkteitqe kepvdfsvks qadrefqffd hhlmesikmg dpkvheflrl lalchtvmse
      481 ensageliyq vqspdegalv taarnfgfif ksrtpetiti eelgtlvtyq llafldfnnt
      541 rkrmsvivrn pegqiklysk gadtilfekl hpsnevllsl tsdhlsefag eglrtlaiay
      601 rdlddkyfke whkmledana ateerderia glyeeierdl mllgataved klqegvietv
      661 tslslaniki wvltgdkqet ainigyacnm ltddmndvfv iagnnavevr eelrkakqnl
      721 fgqnrnfsng hvvcekkqql eldsiveeti tgdyaliing hslahalesd vkndllelac
      781 mcktviccrv tplqkaqvve lvkkyrnavt laigdgandv smiksahigv gisgqeglqa
      841 vlasdysfaq frylqrlllv hgrwsyfrmc kflcyffykn faftlvhfwf gffcgfsaqt
      901 vydqwfitlf nivytslpvl amgifdqdvs dqnsvdcpql ykpgqlnllf nkrkfficvl
      961 hgiytslvlf fipygafynv agedgqhiad yqsfavtmat slvivvsvqi aldtsywtfi
     1021 nhvfiwgsia iyfsilftmh sngifgifpn qfpfvgnarh sltqkciwlv illttvasvm
     1081 pvvafrflkv dlyptlsdqi rrwqkaqkka rppssrrprt rrsssrrsgy afahqegyge
     1141 litsgknmra knppptsgle kthynstswi enlckkttdt vssfsqdktv kl
//
LOCUS       XP_016878076            1192 aa            linear   PRI 05-AUG-2025
DEFINITION  putative phospholipid-transporting ATPase IM isoform X6 [Homo
            sapiens].
ACCESSION   XP_016878076
VERSION     XP_016878076.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022587.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Mar 26, 2018 this sequence version replaced XP_016878076.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1192
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1192
                     /product="putative phospholipid-transporting ATPase IM
                     isoform X6"
                     /calculated_mol_wt=135738
     Region          30..973
                     /region_name="P-type_ATPase_APLT_Dnf-like"
                     /note="Aminophospholipid translocases (APLTs), similar to
                     Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2,
                     -10D, -11B, -11C; cd02073"
                     /db_xref="CDD:319770"
     Site            order(392..394,537,560..562,627,674..676,789,792,795,815,
                     818)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:319770"
     CDS             1..1192
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /coded_by="XM_017022587.3:143..3721"
                     /db_xref="GeneID:79895"
                     /db_xref="HGNC:HGNC:13536"
                     /db_xref="MIM:609123"
ORIGIN      
        1 mfcsekklre verivkandr eynekfqyad nrihtskyni ltflpinlfe qfqrvanayf
       61 lcllilqlip eissltwftt ivplvlvitm tavkdatddy frhksdnqvn nrqsevlins
      121 klqnekwmnv kvgdiiklen nqfvaadlll lsssephglc yvetaeldge tnlkvrhals
      181 vtselgadis rlagfdgivv cevpnnkldk fmgilswkds khslnnekii lrgcilrnts
      241 wcfgmvifag pdtklmqnsg ktkfkrtsid rlmntlvlwi fgfliclgii laignsiwes
      301 qtgdqfrtfl fwnegekssv fsgfltfwsy iiilntvvpi slyvsvevir lghsyfinwd
      361 rkmyysrkai pavartttln eelgqieyif sdktgtltqn imtfkrcsin griygevhdd
      421 ldqkteitqe kepvdfsvks qadrefqffd hhlmesikmg dpkvheflrl lalchtvmse
      481 ensageliyq vqspdegalv taarnfgfif ksrtpetiti eelgtlvtyq llafldfnnt
      541 rkrmsvivrn pegqiklysk gadtilfekl hpsnevllsl tsdhlsefag eglrtlaiay
      601 rdlddkyfke whkmledana ateerderia glyeeierdl mllgataved klqegvietv
      661 tslslaniki wvltgdkqet ainigyacnm ltddmndvfv iagnnavevr eelrkakqnl
      721 fgqnrnfsng hvvcekkqql eldsiveeti tgdyaliing hslahalesd vkndllelac
      781 mcktviccrv tplqkaqvve lvkkyrnavt laigdgandv smiksahigv gisgqeglqa
      841 vlasdysfaq frylqrlllv hgrwsyfrmc kflcyffykn faftlvhfwf gffcgfsaqt
      901 vydqwfitlf nivytslpvl amgifdqdvs dqnsvdcpql ykpgqlnllf nkrkfficvl
      961 hgiytslvlf fipygafynv agedgqhiad yqsfavtmat slvivvsvqi aldtsywtfi
     1021 nhvfiwgsia iyfsilftmh sngifgifpn qfpfvgnarh sltqkciwlv illttvasvm
     1081 pvvafrflkv dlyptlsdqi rrwqkaqkka rppssrrprt rrsssrrsgy afahqegyge
     1141 litsgknmra knppptsgle kthynstswi enlckkttdt vssfsqdktv kl
//
LOCUS       XP_047289040            1186 aa            linear   PRI 05-AUG-2025
DEFINITION  putative phospholipid-transporting ATPase IM isoform X7 [Homo
            sapiens].
ACCESSION   XP_047289040
VERSION     XP_047289040.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433084.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1186
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1186
                     /product="putative phospholipid-transporting ATPase IM
                     isoform X7"
                     /calculated_mol_wt=134644
     Region          68..967
                     /region_name="P-type_ATPase_APLT_Dnf-like"
                     /note="Aminophospholipid translocases (APLTs), similar to
                     Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2,
                     -10D, -11B, -11C; cd02073"
                     /db_xref="CDD:319770"
     Site            order(386..388,531,554..556,621,668..670,783,786,789,809,
                     812)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:319770"
     CDS             1..1186
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /coded_by="XM_047433084.1:206..3766"
                     /db_xref="GeneID:79895"
                     /db_xref="HGNC:HGNC:13536"
                     /db_xref="MIM:609123"
ORIGIN      
        1 mkddffftlt tfrggasvsg gisvghllrp gersgiimfc sekklrever ivkandreyn
       61 ekfqyafrhk sdnqvnnrqs evlinsklqn ekwmnvkvgd iiklennqfv aadllllsss
      121 ephglcyvet aeldgslccy kdvpwvecql fgaqealptf lkqetnlkvr halsvtselg
      181 adisrlagfd givvcevpnn kldkfmgils wkdskhslnn ekiilrgcil rntswcfgmv
      241 ifagpdtklm qnsgktkfkr tsidrlmntl vlwifgflic lgiilaigns iwesqtgdqf
      301 rtflfwnege kssvfsgflt fwsyiiilnt vvpislyvsv evirlghsyf inwdrkmyys
      361 rkaipavart ttlneelgqi eyifsdktgt ltqnimtfkr csingriyge vhddldqkte
      421 itqekepvdf svksqadref qffdhhlmes ikmgdpkvhe flrllalcht vmseensage
      481 liyqvqspde galvtaarnf gfifksrtpe titieelgtl vtyqllafld fnntrkrmsv
      541 ivrnpegqik lyskgadtil feklhpsnev llsltsdhls efageglrtl aiayrdlddk
      601 yfkewhkmle danaateerd eriaglyeei erdlmllgat avedklqegv ietvtslsla
      661 nikiwvltgd kqetainigy acnmltddmn dvfviagnna vevreelrka kqnlfgqnrn
      721 fsnghvvcek kqqleldsiv eetitgdyal iinghslaha lesdvkndll elacmcktvi
      781 ccrvtplqka qvvelvkkyr navtlaigdg andvsmiksa higvgisgqe glqavlasdy
      841 sfaqfrylqr lllvhgrwsy frmckflcyf fyknfaftlv hfwfgffcgf saqtvydqwf
      901 itlfnivyts lpvlamgifd qdvsdqnsvd cpqlykpgql nllfnkrkff icvlhgiyts
      961 lvlffipyga fynvagedgq hiadyqsfav tmatslvivv svqialdtsy wtfinhvfiw
     1021 gsiaiyfsil ftmhsngifg ifpnqfpfvg narhsltqkc iwlvillttv asvmpvvafr
     1081 flkvdlyptl sdqirrwqka qkkarppssr rprtrrsssr rsgyafahqe gygelitsgk
     1141 nmraknpppt sglekthyns tswienlckk ttdtvssfsq dktvkl
//
LOCUS       XP_047289041            1176 aa            linear   PRI 05-AUG-2025
DEFINITION  putative phospholipid-transporting ATPase IM isoform X8 [Homo
            sapiens].
ACCESSION   XP_047289041
VERSION     XP_047289041.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433085.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1176
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1176
                     /product="putative phospholipid-transporting ATPase IM
                     isoform X8"
                     /calculated_mol_wt=133625
     Region          67..957
                     /region_name="P-type_ATPase_APLT_Dnf-like"
                     /note="Aminophospholipid translocases (APLTs), similar to
                     Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2,
                     -10D, -11B, -11C; cd02073"
                     /db_xref="CDD:319770"
     Site            order(376..378,521,544..546,611,658..660,773,776,779,799,
                     802)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:319770"
     CDS             1..1176
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /coded_by="XM_047433085.1:206..3736"
                     /db_xref="GeneID:79895"
                     /db_xref="HGNC:HGNC:13536"
                     /db_xref="MIM:609123"
ORIGIN      
        1 mkddffftlt tfrggasvsg gisvghllrp gersgiimfc sekklrever ivkandreyn
       61 ekfqyadnri htskyniltf lpinlfeqfq rvanayflcl lilqlipeis sltwfttivp
      121 lvlvitmtav kdatddyfrh ksdnqvnnrq sevlinsklq nekwmnvkvg diiklennqf
      181 vaadllllss sephglcyve taeldgetnl kvrhalsvts elgadisrla gfdgpdtklm
      241 qnsgktkfkr tsidrlmntl vlwifgflic lgiilaigns iwesqtgdqf rtflfwnege
      301 kssvfsgflt fwsyiiilnt vvpislyvsv evirlghsyf inwdrkmyys rkaipavart
      361 ttlneelgqi eyifsdktgt ltqnimtfkr csingriyge vhddldqkte itqekepvdf
      421 svksqadref qffdhhlmes ikmgdpkvhe flrllalcht vmseensage liyqvqspde
      481 galvtaarnf gfifksrtpe titieelgtl vtyqllafld fnntrkrmsv ivrnpegqik
      541 lyskgadtil feklhpsnev llsltsdhls efageglrtl aiayrdlddk yfkewhkmle
      601 danaateerd eriaglyeei erdlmllgat avedklqegv ietvtslsla nikiwvltgd
      661 kqetainigy acnmltddmn dvfviagnna vevreelrka kqnlfgqnrn fsnghvvcek
      721 kqqleldsiv eetitgdyal iinghslaha lesdvkndll elacmcktvi ccrvtplqka
      781 qvvelvkkyr navtlaigdg andvsmiksa higvgisgqe glqavlasdy sfaqfrylqr
      841 lllvhgrwsy frmckflcyf fyknfaftlv hfwfgffcgf saqtvydqwf itlfnivyts
      901 lpvlamgifd qdvsdqnsvd cpqlykpgql nllfnkrkff icvlhgiyts lvlffipyga
      961 fynvagedgq hiadyqsfav tmatslvivv svqialdtsy wtfinhvfiw gsiaiyfsil
     1021 ftmhsngifg ifpnqfpfvg narhsltqkc iwlvillttv asvmpvvafr flkvdlyptl
     1081 sdqirrwqka qkkarppssr rprtrrsssr rsgyafahqe gygelitsgk nmraknpppt
     1141 sglekthyns tswienlckk ttdtvssfsq dktvkl
//
LOCUS       XP_047289042            1166 aa            linear   PRI 05-AUG-2025
DEFINITION  putative phospholipid-transporting ATPase IM isoform X9 [Homo
            sapiens].
ACCESSION   XP_047289042
VERSION     XP_047289042.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433086.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1166
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1166
                     /product="putative phospholipid-transporting ATPase IM
                     isoform X9"
                     /calculated_mol_wt=132540
     Region          67..947
                     /region_name="P-type_ATPase_APLT_Dnf-like"
                     /note="Aminophospholipid translocases (APLTs), similar to
                     Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2,
                     -10D, -11B, -11C; cd02073"
                     /db_xref="CDD:319770"
     Site            order(429..431,518,534..536,601,648..650,763,766,769,789,
                     792)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:319770"
     CDS             1..1166
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /coded_by="XM_047433086.1:206..3706"
                     /db_xref="GeneID:79895"
                     /db_xref="HGNC:HGNC:13536"
                     /db_xref="MIM:609123"
ORIGIN      
        1 mkddffftlt tfrggasvsg gisvghllrp gersgiimfc sekklrever ivkandreyn
       61 ekfqyadnri htskyniltf lpinlfeqfq rvanayflcl lilqlipeis sltwfttivp
      121 lvlvitmtav kdatddyfrh ksdnqvnnrq sevlinsklq nekwmnvkvg diiklennqf
      181 vaadllllss sephglcyve taeldgetnl kvrhalsvts elgadisrla gfdgivvcev
      241 pnnkldkfmg ilswkdskhs lnnekiilrg cilrntswcf gmvifagpdt klmqnsgktk
      301 fkrtsidrlm ntlvlwifgf liclgiilai gnsiwesqtg dqfrtflfwn egekssvfsg
      361 fltfwsyiii lntvvpisly vsvevirlgh syfinwdrkm yysrkaipav artttlneel
      421 gqieyifsdk tgtltqnimt fkrcsingri ygevhddldq kteitqekep vdfsvksqad
      481 refqffdhhl mesikmgdpk vheflrllal chtvmseens avrnpegqik lyskgadtil
      541 feklhpsnev llsltsdhls efageglrtl aiayrdlddk yfkewhkmle danaateerd
      601 eriaglyeei erdlmllgat avedklqegv ietvtslsla nikiwvltgd kqetainigy
      661 acnmltddmn dvfviagnna vevreelrka kqnlfgqnrn fsnghvvcek kqqleldsiv
      721 eetitgdyal iinghslaha lesdvkndll elacmcktvi ccrvtplqka qvvelvkkyr
      781 navtlaigdg andvsmiksa higvgisgqe glqavlasdy sfaqfrylqr lllvhgrwsy
      841 frmckflcyf fyknfaftlv hfwfgffcgf saqtvydqwf itlfnivyts lpvlamgifd
      901 qdvsdqnsvd cpqlykpgql nllfnkrkff icvlhgiyts lvlffipyga fynvagedgq
      961 hiadyqsfav tmatslvivv svqialdtsy wtfinhvfiw gsiaiyfsil ftmhsngifg
     1021 ifpnqfpfvg narhsltqkc iwlvillttv asvmpvvafr flkvdlyptl sdqirrwqka
     1081 qkkarppssr rprtrrsssr rsgyafahqe gygelitsgk nmraknpppt sglekthyns
     1141 tswienlckk ttdtvssfsq dktvkl
//
LOCUS       XP_047289043            1158 aa            linear   PRI 05-AUG-2025
DEFINITION  putative phospholipid-transporting ATPase IM isoform X10 [Homo
            sapiens].
ACCESSION   XP_047289043
VERSION     XP_047289043.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433087.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1158
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1158
                     /product="putative phospholipid-transporting ATPase IM
                     isoform X10"
                     /calculated_mol_wt=131445
     Region          68..939
                     /region_name="P-type_ATPase_APLT_Dnf-like"
                     /note="Aminophospholipid translocases (APLTs), similar to
                     Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2,
                     -10D, -11B, -11C; cd02073"
                     /db_xref="CDD:319770"
     Site            order(358..360,503,526..528,593,640..642,755,758,761,781,
                     784)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:319770"
     CDS             1..1158
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /coded_by="XM_047433087.1:206..3682"
                     /db_xref="GeneID:79895"
                     /db_xref="HGNC:HGNC:13536"
                     /db_xref="MIM:609123"
ORIGIN      
        1 mkddffftlt tfrggasvsg gisvghllrp gersgiimfc sekklrever ivkandreyn
       61 ekfqyafrhk sdnqvnnrqs evlinsklqn ekwmnvkvgd iiklennqfv aadllllsss
      121 ephglcyvet aeldgetnlk vrhalsvtse lgadisrlag fdgivvcevp nnkldkfmgi
      181 lswkdskhsl nnekiilrgc ilrntswcfg mvifagpdtk lmqnsgktkf krtsidrlmn
      241 tlvlwifgfl iclgiilaig nsiwesqtgd qfrtflfwne gekssvfsgf ltfwsyiiil
      301 ntvvpislyv svevirlghs yfinwdrkmy ysrkaipava rtttlneelg qieyifsdkt
      361 gtltqnimtf krcsingriy gevhddldqk teitqekepv dfsvksqadr efqffdhhlm
      421 esikmgdpkv heflrllalc htvmseensa geliyqvqsp degalvtaar nfgfifksrt
      481 petitieelg tlvtyqllaf ldfnntrkrm svivrnpegq iklyskgadt ilfeklhpsn
      541 evllsltsdh lsefageglr tlaiayrdld dkyfkewhkm ledanaatee rderiaglye
      601 eierdlmllg atavedklqe gvietvtsls lanikiwvlt gdkqetaini gyacnmltdd
      661 mndvfviagn navevreelr kakqnlfgqn rnfsnghvvc ekkqqlelds iveetitgdy
      721 aliinghsla halesdvknd llelacmckt viccrvtplq kaqvvelvkk yrnavtlaig
      781 dgandvsmik sahigvgisg qeglqavlas dysfaqfryl qrlllvhgrw syfrmckflc
      841 yffyknfaft lvhfwfgffc gfsaqtvydq wfitlfnivy tslpvlamgi fdqdvsdqns
      901 vdcpqlykpg qlnllfnkrk fficvlhgiy tslvlffipy gafynvaged gqhiadyqsf
      961 avtmatslvi vvsvqialdt sywtfinhvf iwgsiaiyfs ilftmhsngi fgifpnqfpf
     1021 vgnarhsltq kciwlvillt tvasvmpvva frflkvdlyp tlsdqirrwq kaqkkarpps
     1081 srrprtrrss srrsgyafah qegygelits gknmraknpp ptsglekthy nstswienlc
     1141 kkttdtvssf sqdktvkl
//
LOCUS       XP_047289044            1149 aa            linear   PRI 05-AUG-2025
DEFINITION  putative phospholipid-transporting ATPase IM isoform X11 [Homo
            sapiens].
ACCESSION   XP_047289044
VERSION     XP_047289044.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433088.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1149
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1149
                     /product="putative phospholipid-transporting ATPase IM
                     isoform X11"
                     /calculated_mol_wt=130735
     Region          31..930
                     /region_name="P-type_ATPase_APLT_Dnf-like"
                     /note="Aminophospholipid translocases (APLTs), similar to
                     Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2,
                     -10D, -11B, -11C; cd02073"
                     /db_xref="CDD:319770"
     Site            order(349..351,494,517..519,584,631..633,746,749,752,772,
                     775)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:319770"
     CDS             1..1149
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /coded_by="XM_047433088.1:110..3559"
                     /db_xref="GeneID:79895"
                     /db_xref="HGNC:HGNC:13536"
                     /db_xref="MIM:609123"
ORIGIN      
        1 mfcsekklre verivkandr eynekfqyaf rhksdnqvnn rqsevlinsk lqnekwmnvk
       61 vgdiiklenn qfvaadllll sssephglcy vetaeldgsl ccykdvpwve cqlfgaqeal
      121 ptflkqetnl kvrhalsvts elgadisrla gfdgivvcev pnnkldkfmg ilswkdskhs
      181 lnnekiilrg cilrntswcf gmvifagpdt klmqnsgktk fkrtsidrlm ntlvlwifgf
      241 liclgiilai gnsiwesqtg dqfrtflfwn egekssvfsg fltfwsyiii lntvvpisly
      301 vsvevirlgh syfinwdrkm yysrkaipav artttlneel gqieyifsdk tgtltqnimt
      361 fkrcsingri ygevhddldq kteitqekep vdfsvksqad refqffdhhl mesikmgdpk
      421 vheflrllal chtvmseens ageliyqvqs pdegalvtaa rnfgfifksr tpetitieel
      481 gtlvtyqlla fldfnntrkr msvivrnpeg qiklyskgad tilfeklhps nevllsltsd
      541 hlsefagegl rtlaiayrdl ddkyfkewhk mledanaate erderiagly eeierdlmll
      601 gatavedklq egvietvtsl slanikiwvl tgdkqetain igyacnmltd dmndvfviag
      661 nnavevreel rkakqnlfgq nrnfsnghvv cekkqqleld siveetitgd yaliinghsl
      721 ahalesdvkn dllelacmck tviccrvtpl qkaqvvelvk kyrnavtlai gdgandvsmi
      781 ksahigvgis gqeglqavla sdysfaqfry lqrlllvhgr wsyfrmckfl cyffyknfaf
      841 tlvhfwfgff cgfsaqtvyd qwfitlfniv ytslpvlamg ifdqdvsdqn svdcpqlykp
      901 gqlnllfnkr kfficvlhgi ytslvlffip ygafynvage dgqhiadyqs favtmatslv
      961 ivvsvqiald tsywtfinhv fiwgsiaiyf silftmhsng ifgifpnqfp fvgnarhslt
     1021 qkciwlvill ttvasvmpvv afrflkvdly ptlsdqirrw qkaqkkarpp ssrrprtrrs
     1081 ssrrsgyafa hqegygelit sgknmraknp pptsglekth ynstswienl ckkttdtvss
     1141 fsqdktvkl
//
LOCUS       XP_047289045            1129 aa            linear   PRI 05-AUG-2025
DEFINITION  putative phospholipid-transporting ATPase IM isoform X12 [Homo
            sapiens].
ACCESSION   XP_047289045
VERSION     XP_047289045.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433089.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1129
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1129
                     /product="putative phospholipid-transporting ATPase IM
                     isoform X12"
                     /calculated_mol_wt=128631
     Region          30..910
                     /region_name="P-type_ATPase_APLT_Dnf-like"
                     /note="Aminophospholipid translocases (APLTs), similar to
                     Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2,
                     -10D, -11B, -11C; cd02073"
                     /db_xref="CDD:319770"
     Site            order(392..394,481,497..499,564,611..613,726,729,732,752,
                     755)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:319770"
     CDS             1..1129
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /coded_by="XM_047433089.1:110..3499"
                     /db_xref="GeneID:79895"
                     /db_xref="HGNC:HGNC:13536"
                     /db_xref="MIM:609123"
ORIGIN      
        1 mfcsekklre verivkandr eynekfqyad nrihtskyni ltflpinlfe qfqrvanayf
       61 lcllilqlip eissltwftt ivplvlvitm tavkdatddy frhksdnqvn nrqsevlins
      121 klqnekwmnv kvgdiiklen nqfvaadlll lsssephglc yvetaeldge tnlkvrhals
      181 vtselgadis rlagfdgivv cevpnnkldk fmgilswkds khslnnekii lrgcilrnts
      241 wcfgmvifag pdtklmqnsg ktkfkrtsid rlmntlvlwi fgfliclgii laignsiwes
      301 qtgdqfrtfl fwnegekssv fsgfltfwsy iiilntvvpi slyvsvevir lghsyfinwd
      361 rkmyysrkai pavartttln eelgqieyif sdktgtltqn imtfkrcsin griygevhdd
      421 ldqkteitqe kepvdfsvks qadrefqffd hhlmesikmg dpkvheflrl lalchtvmse
      481 ensavrnpeg qiklyskgad tilfeklhps nevllsltsd hlsefagegl rtlaiayrdl
      541 ddkyfkewhk mledanaate erderiagly eeierdlmll gatavedklq egvietvtsl
      601 slanikiwvl tgdkqetain igyacnmltd dmndvfviag nnavevreel rkakqnlfgq
      661 nrnfsnghvv cekkqqleld siveetitgd yaliinghsl ahalesdvkn dllelacmck
      721 tviccrvtpl qkaqvvelvk kyrnavtlai gdgandvsmi ksahigvgis gqeglqavla
      781 sdysfaqfry lqrlllvhgr wsyfrmckfl cyffyknfaf tlvhfwfgff cgfsaqtvyd
      841 qwfitlfniv ytslpvlamg ifdqdvsdqn svdcpqlykp gqlnllfnkr kfficvlhgi
      901 ytslvlffip ygafynvage dgqhiadyqs favtmatslv ivvsvqiald tsywtfinhv
      961 fiwgsiaiyf silftmhsng ifgifpnqfp fvgnarhslt qkciwlvill ttvasvmpvv
     1021 afrflkvdly ptlsdqirrw qkaqkkarpp ssrrprtrrs ssrrsgyafa hqegygelit
     1081 sgknmraknp pptsglekth ynstswienl ckkttdtvss fsqdktvkl
//
LOCUS       XP_047289046            1121 aa            linear   PRI 05-AUG-2025
DEFINITION  putative phospholipid-transporting ATPase IM isoform X13 [Homo
            sapiens].
ACCESSION   XP_047289046
VERSION     XP_047289046.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433090.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1121
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1121
                     /product="putative phospholipid-transporting ATPase IM
                     isoform X13"
                     /calculated_mol_wt=127535
     Region          31..902
                     /region_name="P-type_ATPase_APLT_Dnf-like"
                     /note="Aminophospholipid translocases (APLTs), similar to
                     Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2,
                     -10D, -11B, -11C; cd02073"
                     /db_xref="CDD:319770"
     Site            order(321..323,466,489..491,556,603..605,718,721,724,744,
                     747)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:319770"
     CDS             1..1121
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /coded_by="XM_047433090.1:110..3475"
                     /db_xref="GeneID:79895"
                     /db_xref="HGNC:HGNC:13536"
                     /db_xref="MIM:609123"
ORIGIN      
        1 mfcsekklre verivkandr eynekfqyaf rhksdnqvnn rqsevlinsk lqnekwmnvk
       61 vgdiiklenn qfvaadllll sssephglcy vetaeldget nlkvrhalsv tselgadisr
      121 lagfdgivvc evpnnkldkf mgilswkdsk hslnnekiil rgcilrntsw cfgmvifagp
      181 dtklmqnsgk tkfkrtsidr lmntlvlwif gfliclgiil aignsiwesq tgdqfrtflf
      241 wnegekssvf sgfltfwsyi iilntvvpis lyvsvevirl ghsyfinwdr kmyysrkaip
      301 avartttlne elgqieyifs dktgtltqni mtfkrcsing riygevhddl dqkteitqek
      361 epvdfsvksq adrefqffdh hlmesikmgd pkvheflrll alchtvmsee nsageliyqv
      421 qspdegalvt aarnfgfifk srtpetitie elgtlvtyql lafldfnntr krmsvivrnp
      481 egqiklyskg adtilfeklh psnevllslt sdhlsefage glrtlaiayr dlddkyfkew
      541 hkmledanaa teerderiag lyeeierdlm llgatavedk lqegvietvt slslanikiw
      601 vltgdkqeta inigyacnml tddmndvfvi agnnavevre elrkakqnlf gqnrnfsngh
      661 vvcekkqqle ldsiveetit gdyaliingh slahalesdv kndllelacm cktviccrvt
      721 plqkaqvvel vkkyrnavtl aigdgandvs miksahigvg isgqeglqav lasdysfaqf
      781 rylqrlllvh grwsyfrmck flcyffyknf aftlvhfwfg ffcgfsaqtv ydqwfitlfn
      841 ivytslpvla mgifdqdvsd qnsvdcpqly kpgqlnllfn krkfficvlh giytslvlff
      901 ipygafynva gedgqhiady qsfavtmats lvivvsvqia ldtsywtfin hvfiwgsiai
      961 yfsilftmhs ngifgifpnq fpfvgnarhs ltqkciwlvi llttvasvmp vvafrflkvd
     1021 lyptlsdqir rwqkaqkkar ppssrrprtr rsssrrsgya fahqegygel itsgknmrak
     1081 nppptsglek thynstswie nlckkttdtv ssfsqdktvk l
//
LOCUS       XP_011520358            1220 aa            linear   PRI 05-AUG-2025
DEFINITION  putative phospholipid-transporting ATPase IM isoform X3 [Homo
            sapiens].
ACCESSION   XP_011520358
VERSION     XP_011520358.3
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522056.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Mar 26, 2018 this sequence version replaced XP_011520358.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1220
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1220
                     /product="putative phospholipid-transporting ATPase IM
                     isoform X3"
                     /calculated_mol_wt=138937
     Region          30..1001
                     /region_name="P-type_ATPase_APLT_Dnf-like"
                     /note="Aminophospholipid translocases (APLTs), similar to
                     Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2,
                     -10D, -11B, -11C; cd02073"
                     /db_xref="CDD:319770"
     Site            order(420..422,565,588..590,655,702..704,817,820,823,843,
                     846)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:319770"
     CDS             1..1220
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /coded_by="XM_011522056.4:266..3928"
                     /db_xref="GeneID:79895"
                     /db_xref="HGNC:HGNC:13536"
                     /db_xref="MIM:609123"
ORIGIN      
        1 mfcsekklre verivkandr eynekfqyad nrihtskyni ltflpinlfe qfqrvanayf
       61 lcllilqlip eissltwftt ivplvlvitm tavkdatddy frhksdnqvn nrqsevlins
      121 klqnekwmnv kvgdiiklen nqfvaadlll lsssephglc yvetaeldgs lccykdvpwv
      181 ecqlfgaqea lptflkqetn lkvrhalsvt selgadisrl agfdgivvce vpnnkldkfm
      241 gilswkdskh slnnekiilr gcilrntswc fgmvifagpd tklmqnsgkt kfkrtsidrl
      301 mntlvlwifg fliclgiila ignsiwesqt gdqfrtflfw negekssvfs gfltfwsyii
      361 ilntvvpisl yvsvevirlg hsyfinwdrk myysrkaipa vartttlnee lgqieyifsd
      421 ktgtltqnim tfkrcsingr iygevhddld qkteitqeke pvdfsvksqa drefqffdhh
      481 lmesikmgdp kvheflrlla lchtvmseen sageliyqvq spdegalvta arnfgfifks
      541 rtpetitiee lgtlvtyqll afldfnntrk rmsvivrnpe gqiklyskga dtilfeklhp
      601 snevllslts dhlsefageg lrtlaiayrd lddkyfkewh kmledanaat eerderiagl
      661 yeeierdlml lgatavedkl qegvietvts lslanikiwv ltgdkqetai nigyacnmlt
      721 ddmndvfvia gnnavevree lrkakqnlfg qnrnfsnghv vcekkqqlel dsiveetitg
      781 dyaliinghs lahalesdvk ndllelacmc ktviccrvtp lqkaqvvelv kkyrnavtla
      841 igdgandvsm iksahigvgi sgqeglqavl asdysfaqfr ylqrlllvhg rwsyfrmckf
      901 lcyffyknfa ftlvhfwfgf fcgfsaqtvy dqwfitlfni vytslpvlam gifdqdvsdq
      961 nsvdcpqlyk pgqlnllfnk rkfficvlhg iytslvlffi pygafynvag edgqhiadyq
     1021 sfavtmatsl vivvsvqial dtsywtfinh vfiwgsiaiy fsilftmhsn gifgifpnqf
     1081 pfvgnarhsl tqkciwlvil lttvasvmpv vafrflkvdl yptlsdqirr wqkaqkkarp
     1141 pssrrprtrr sssrrsgyaf ahqegygeli tsgknmrakn ppptsglekt hynstswien
     1201 lckkttdtvs sfsqdktvkl
//
LOCUS       XP_047289047            1113 aa            linear   PRI 05-AUG-2025
DEFINITION  putative phospholipid-transporting ATPase IM isoform X14 [Homo
            sapiens].
ACCESSION   XP_047289047
VERSION     XP_047289047.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433091.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1113
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1113
                     /product="putative phospholipid-transporting ATPase IM
                     isoform X14"
                     /calculated_mol_wt=126518
     Region          67..894
                     /region_name="P-type_ATPase_APLT_Dnf-like"
                     /note="Aminophospholipid translocases (APLTs), similar to
                     Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2,
                     -10D, -11B, -11C; cd02073"
                     /db_xref="CDD:319770"
     Site            order(376..378,465,481..483,548,595..597,710,713,716,736,
                     739)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:319770"
     CDS             1..1113
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /coded_by="XM_047433091.1:206..3547"
                     /db_xref="GeneID:79895"
                     /db_xref="HGNC:HGNC:13536"
                     /db_xref="MIM:609123"
ORIGIN      
        1 mkddffftlt tfrggasvsg gisvghllrp gersgiimfc sekklrever ivkandreyn
       61 ekfqyadnri htskyniltf lpinlfeqfq rvanayflcl lilqlipeis sltwfttivp
      121 lvlvitmtav kdatddyfrh ksdnqvnnrq sevlinsklq nekwmnvkvg diiklennqf
      181 vaadllllss sephglcyve taeldgetnl kvrhalsvts elgadisrla gfdgpdtklm
      241 qnsgktkfkr tsidrlmntl vlwifgflic lgiilaigns iwesqtgdqf rtflfwnege
      301 kssvfsgflt fwsyiiilnt vvpislyvsv evirlghsyf inwdrkmyys rkaipavart
      361 ttlneelgqi eyifsdktgt ltqnimtfkr csingriyge vhddldqkte itqekepvdf
      421 svksqadref qffdhhlmes ikmgdpkvhe flrllalcht vmseensavr npegqiklys
      481 kgadtilfek lhpsnevlls ltsdhlsefa geglrtlaia yrdlddkyfk ewhkmledan
      541 aateerderi aglyeeierd lmllgatave dklqegviet vtslslanik iwvltgdkqe
      601 tainigyacn mltddmndvf viagnnavev reelrkakqn lfgqnrnfsn ghvvcekkqq
      661 leldsiveet itgdyaliin ghslahales dvkndllela cmcktviccr vtplqkaqvv
      721 elvkkyrnav tlaigdgand vsmiksahig vgisgqeglq avlasdysfa qfrylqrlll
      781 vhgrwsyfrm ckflcyffyk nfaftlvhfw fgffcgfsaq tvydqwfitl fnivytslpv
      841 lamgifdqdv sdqnsvdcpq lykpgqlnll fnkrkfficv lhgiytslvl ffipygafyn
      901 vagedgqhia dyqsfavtma tslvivvsvq ialdtsywtf inhvfiwgsi aiyfsilftm
      961 hsngifgifp nqfpfvgnar hsltqkciwl villttvasv mpvvafrflk vdlyptlsdq
     1021 irrwqkaqkk arppssrrpr trrsssrrsg yafahqegyg elitsgknmr aknppptsgl
     1081 ekthynstsw ienlckkttd tvssfsqdkt vkl
//
LOCUS       XP_016878083            1111 aa            linear   PRI 05-AUG-2025
DEFINITION  putative phospholipid-transporting ATPase IM isoform X15 [Homo
            sapiens].
ACCESSION   XP_016878083
VERSION     XP_016878083.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022594.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1111
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1111
                     /product="putative phospholipid-transporting ATPase IM
                     isoform X15"
                     /calculated_mol_wt=125999
     Region          12..892
                     /region_name="P-type_ATPase_APLT_Dnf-like"
                     /note="Aminophospholipid translocases (APLTs), similar to
                     Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2,
                     -10D, -11B, -11C; cd02073"
                     /db_xref="CDD:319770"
     Site            order(311..313,456,479..481,546,593..595,708,711,714,734,
                     737)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:319770"
     CDS             1..1111
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /coded_by="XM_017022594.1:95..3430"
                     /db_xref="GeneID:79895"
                     /db_xref="HGNC:HGNC:13536"
                     /db_xref="MIM:609123"
ORIGIN      
        1 mtvnimksss mrlqnekwmn vkvgdiikle nnqfvaadll llsssephgl cyvetaeldg
       61 slccykdvpw vecqlfgaqe alptflkqet nlkvrhalsv tselgadisr lagfdgivvc
      121 evpnnkldkf mgilswkdsk hslnnekiil rgcilrntsw cfgmvifagp dtklmqnsgk
      181 tkfkrtsidr lmntlvlwif gfliclgiil aignsiwesq tgdqfrtflf wnegekssvf
      241 sgfltfwsyi iilntvvpis lyvsvevirl ghsyfinwdr kmyysrkaip avartttlne
      301 elgqieyifs dktgtltqni mtfkrcsing riygevhddl dqkteitqek epvdfsvksq
      361 adrefqffdh hlmesikmgd pkvheflrll alchtvmsee nsageliyqv qspdegalvt
      421 aarnfgfifk srtpetitie elgtlvtyql lafldfnntr krmsvivrnp egqiklyskg
      481 adtilfeklh psnevllslt sdhlsefage glrtlaiayr dlddkyfkew hkmledanaa
      541 teerderiag lyeeierdlm llgatavedk lqegvietvt slslanikiw vltgdkqeta
      601 inigyacnml tddmndvfvi agnnavevre elrkakqnlf gqnrnfsngh vvcekkqqle
      661 ldsiveetit gdyaliingh slahalesdv kndllelacm cktviccrvt plqkaqvvel
      721 vkkyrnavtl aigdgandvs miksahigvg isgqeglqav lasdysfaqf rylqrlllvh
      781 grwsyfrmck flcyffyknf aftlvhfwfg ffcgfsaqtv ydqwfitlfn ivytslpvla
      841 mgifdqdvsd qnsvdcpqly kpgqlnllfn krkfficvlh giytslvlff ipygafynva
      901 gedgqhiady qsfavtmats lvivvsvqia ldtsywtfin hvfiwgsiai yfsilftmhs
      961 ngifgifpnq fpfvgnarhs ltqkciwlvi llttvasvmp vvafrflkvd lyptlsdqir
     1021 rwqkaqkkar ppssrrprtr rsssrrsgya fahqegygel itsgknmrak nppptsglek
     1081 thynstswie nlckkttdtv ssfsqdktvk l
//
LOCUS       XP_011520360            1111 aa            linear   PRI 05-AUG-2025
DEFINITION  putative phospholipid-transporting ATPase IM isoform X15 [Homo
            sapiens].
ACCESSION   XP_011520360
VERSION     XP_011520360.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522058.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1111
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1111
                     /product="putative phospholipid-transporting ATPase IM
                     isoform X15"
                     /calculated_mol_wt=125999
     Region          12..892
                     /region_name="P-type_ATPase_APLT_Dnf-like"
                     /note="Aminophospholipid translocases (APLTs), similar to
                     Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2,
                     -10D, -11B, -11C; cd02073"
                     /db_xref="CDD:319770"
     Site            order(311..313,456,479..481,546,593..595,708,711,714,734,
                     737)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:319770"
     CDS             1..1111
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /coded_by="XM_011522058.4:92..3427"
                     /db_xref="GeneID:79895"
                     /db_xref="HGNC:HGNC:13536"
                     /db_xref="MIM:609123"
ORIGIN      
        1 mtvnimksss mrlqnekwmn vkvgdiikle nnqfvaadll llsssephgl cyvetaeldg
       61 slccykdvpw vecqlfgaqe alptflkqet nlkvrhalsv tselgadisr lagfdgivvc
      121 evpnnkldkf mgilswkdsk hslnnekiil rgcilrntsw cfgmvifagp dtklmqnsgk
      181 tkfkrtsidr lmntlvlwif gfliclgiil aignsiwesq tgdqfrtflf wnegekssvf
      241 sgfltfwsyi iilntvvpis lyvsvevirl ghsyfinwdr kmyysrkaip avartttlne
      301 elgqieyifs dktgtltqni mtfkrcsing riygevhddl dqkteitqek epvdfsvksq
      361 adrefqffdh hlmesikmgd pkvheflrll alchtvmsee nsageliyqv qspdegalvt
      421 aarnfgfifk srtpetitie elgtlvtyql lafldfnntr krmsvivrnp egqiklyskg
      481 adtilfeklh psnevllslt sdhlsefage glrtlaiayr dlddkyfkew hkmledanaa
      541 teerderiag lyeeierdlm llgatavedk lqegvietvt slslanikiw vltgdkqeta
      601 inigyacnml tddmndvfvi agnnavevre elrkakqnlf gqnrnfsngh vvcekkqqle
      661 ldsiveetit gdyaliingh slahalesdv kndllelacm cktviccrvt plqkaqvvel
      721 vkkyrnavtl aigdgandvs miksahigvg isgqeglqav lasdysfaqf rylqrlllvh
      781 grwsyfrmck flcyffyknf aftlvhfwfg ffcgfsaqtv ydqwfitlfn ivytslpvla
      841 mgifdqdvsd qnsvdcpqly kpgqlnllfn krkfficvlh giytslvlff ipygafynva
      901 gedgqhiady qsfavtmats lvivvsvqia ldtsywtfin hvfiwgsiai yfsilftmhs
      961 ngifgifpnq fpfvgnarhs ltqkciwlvi llttvasvmp vvafrflkvd lyptlsdqir
     1021 rwqkaqkkar ppssrrprtr rsssrrsgya fahqegygel itsgknmrak nppptsglek
     1081 thynstswie nlckkttdtv ssfsqdktvk l
//
LOCUS       XP_011520361            1105 aa            linear   PRI 05-AUG-2025
DEFINITION  putative phospholipid-transporting ATPase IM isoform X16 [Homo
            sapiens].
ACCESSION   XP_011520361
VERSION     XP_011520361.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522059.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1105
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1105
                     /product="putative phospholipid-transporting ATPase IM
                     isoform X16"
                     /calculated_mol_wt=125334
     Region          11..886
                     /region_name="P-type_ATPase_APLT_Dnf-like"
                     /note="Aminophospholipid translocases (APLTs), similar to
                     Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2,
                     -10D, -11B, -11C; cd02073"
                     /db_xref="CDD:319770"
     Site            order(305..307,450,473..475,540,587..589,702,705,708,728,
                     731)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:319770"
     CDS             1..1105
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /coded_by="XM_011522059.1:83..3400"
                     /db_xref="GeneID:79895"
                     /db_xref="HGNC:HGNC:13536"
                     /db_xref="MIM:609123"
ORIGIN      
        1 mpqmtilqne kwmnvkvgdi iklennqfva adllllssse phglcyveta eldgslccyk
       61 dvpwvecqlf gaqealptfl kqetnlkvrh alsvtselga disrlagfdg ivvcevpnnk
      121 ldkfmgilsw kdskhslnne kiilrgcilr ntswcfgmvi fagpdtklmq nsgktkfkrt
      181 sidrlmntlv lwifgflicl giilaignsi wesqtgdqfr tflfwnegek ssvfsgfltf
      241 wsyiiilntv vpislyvsve virlghsyfi nwdrkmyysr kaipavartt tlneelgqie
      301 yifsdktgtl tqnimtfkrc singriygev hddldqktei tqekepvdfs vksqadrefq
      361 ffdhhlmesi kmgdpkvhef lrllalchtv mseensagel iyqvqspdeg alvtaarnfg
      421 fifksrtpet itieelgtlv tyqllafldf nntrkrmsvi vrnpegqikl yskgadtilf
      481 eklhpsnevl lsltsdhlse fageglrtla iayrdlddky fkewhkmled anaateerde
      541 riaglyeeie rdlmllgata vedklqegvi etvtslslan ikiwvltgdk qetainigya
      601 cnmltddmnd vfviagnnav evreelrkak qnlfgqnrnf snghvvcekk qqleldsive
      661 etitgdyali inghslahal esdvkndlle lacmcktvic crvtplqkaq vvelvkkyrn
      721 avtlaigdga ndvsmiksah igvgisgqeg lqavlasdys faqfrylqrl llvhgrwsyf
      781 rmckflcyff yknfaftlvh fwfgffcgfs aqtvydqwfi tlfnivytsl pvlamgifdq
      841 dvsdqnsvdc pqlykpgqln llfnkrkffi cvlhgiytsl vlffipygaf ynvagedgqh
      901 iadyqsfavt matslvivvs vqialdtsyw tfinhvfiwg siaiyfsilf tmhsngifgi
      961 fpnqfpfvgn arhsltqkci wlvillttva svmpvvafrf lkvdlyptls dqirrwqkaq
     1021 kkarppssrr prtrrsssrr sgyafahqeg ygelitsgkn mraknpppts glekthynst
     1081 swienlckkt tdtvssfsqd ktvkl
//
LOCUS       XP_011520362            1093 aa            linear   PRI 05-AUG-2025
DEFINITION  putative phospholipid-transporting ATPase IM isoform X17 [Homo
            sapiens].
ACCESSION   XP_011520362
VERSION     XP_011520362.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522060.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1093
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1093
                     /product="putative phospholipid-transporting ATPase IM
                     isoform X17"
                     /calculated_mol_wt=123833
     Region          2..874
                     /region_name="P-type_ATPase_APLT_Dnf-like"
                     /note="Aminophospholipid translocases (APLTs), similar to
                     Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2,
                     -10D, -11B, -11C; cd02073"
                     /db_xref="CDD:319770"
     Site            order(293..295,438,461..463,528,575..577,690,693,696,716,
                     719)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:319770"
     CDS             1..1093
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /coded_by="XM_011522060.1:354..3635"
                     /db_xref="GeneID:79895"
                     /db_xref="HGNC:HGNC:13536"
                     /db_xref="MIM:609123"
ORIGIN      
        1 mnvkvgdiik lennqfvaad llllssseph glcyvetael dgslccykdv pwvecqlfga
       61 qealptflkq etnlkvrhal svtselgadi srlagfdgiv vcevpnnkld kfmgilswkd
      121 skhslnneki ilrgcilrnt swcfgmvifa gpdtklmqns gktkfkrtsi drlmntlvlw
      181 ifgfliclgi ilaignsiwe sqtgdqfrtf lfwnegekss vfsgfltfws yiiilntvvp
      241 islyvsvevi rlghsyfinw drkmyysrka ipavartttl neelgqieyi fsdktgtltq
      301 nimtfkrcsi ngriygevhd dldqkteitq ekepvdfsvk sqadrefqff dhhlmesikm
      361 gdpkvheflr llalchtvms eensageliy qvqspdegal vtaarnfgfi fksrtpetit
      421 ieelgtlvty qllafldfnn trkrmsvivr npegqiklys kgadtilfek lhpsnevlls
      481 ltsdhlsefa geglrtlaia yrdlddkyfk ewhkmledan aateerderi aglyeeierd
      541 lmllgatave dklqegviet vtslslanik iwvltgdkqe tainigyacn mltddmndvf
      601 viagnnavev reelrkakqn lfgqnrnfsn ghvvcekkqq leldsiveet itgdyaliin
      661 ghslahales dvkndllela cmcktviccr vtplqkaqvv elvkkyrnav tlaigdgand
      721 vsmiksahig vgisgqeglq avlasdysfa qfrylqrlll vhgrwsyfrm ckflcyffyk
      781 nfaftlvhfw fgffcgfsaq tvydqwfitl fnivytslpv lamgifdqdv sdqnsvdcpq
      841 lykpgqlnll fnkrkfficv lhgiytslvl ffipygafyn vagedgqhia dyqsfavtma
      901 tslvivvsvq ialdtsywtf inhvfiwgsi aiyfsilftm hsngifgifp nqfpfvgnar
      961 hsltqkciwl villttvasv mpvvafrflk vdlyptlsdq irrwqkaqkk arppssrrpr
     1021 trrsssrrsg yafahqegyg elitsgknmr aknppptsgl ekthynstsw ienlckkttd
     1081 tvssfsqdkt vkl
//
LOCUS       XP_011520363            1093 aa            linear   PRI 05-AUG-2025
DEFINITION  putative phospholipid-transporting ATPase IM isoform X17 [Homo
            sapiens].
ACCESSION   XP_011520363
VERSION     XP_011520363.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522061.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1093
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1093
                     /product="putative phospholipid-transporting ATPase IM
                     isoform X17"
                     /calculated_mol_wt=123833
     Region          2..874
                     /region_name="P-type_ATPase_APLT_Dnf-like"
                     /note="Aminophospholipid translocases (APLTs), similar to
                     Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2,
                     -10D, -11B, -11C; cd02073"
                     /db_xref="CDD:319770"
     Site            order(293..295,438,461..463,528,575..577,690,693,696,716,
                     719)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:319770"
     CDS             1..1093
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /coded_by="XM_011522061.1:269..3550"
                     /db_xref="GeneID:79895"
                     /db_xref="HGNC:HGNC:13536"
                     /db_xref="MIM:609123"
ORIGIN      
        1 mnvkvgdiik lennqfvaad llllssseph glcyvetael dgslccykdv pwvecqlfga
       61 qealptflkq etnlkvrhal svtselgadi srlagfdgiv vcevpnnkld kfmgilswkd
      121 skhslnneki ilrgcilrnt swcfgmvifa gpdtklmqns gktkfkrtsi drlmntlvlw
      181 ifgfliclgi ilaignsiwe sqtgdqfrtf lfwnegekss vfsgfltfws yiiilntvvp
      241 islyvsvevi rlghsyfinw drkmyysrka ipavartttl neelgqieyi fsdktgtltq
      301 nimtfkrcsi ngriygevhd dldqkteitq ekepvdfsvk sqadrefqff dhhlmesikm
      361 gdpkvheflr llalchtvms eensageliy qvqspdegal vtaarnfgfi fksrtpetit
      421 ieelgtlvty qllafldfnn trkrmsvivr npegqiklys kgadtilfek lhpsnevlls
      481 ltsdhlsefa geglrtlaia yrdlddkyfk ewhkmledan aateerderi aglyeeierd
      541 lmllgatave dklqegviet vtslslanik iwvltgdkqe tainigyacn mltddmndvf
      601 viagnnavev reelrkakqn lfgqnrnfsn ghvvcekkqq leldsiveet itgdyaliin
      661 ghslahales dvkndllela cmcktviccr vtplqkaqvv elvkkyrnav tlaigdgand
      721 vsmiksahig vgisgqeglq avlasdysfa qfrylqrlll vhgrwsyfrm ckflcyffyk
      781 nfaftlvhfw fgffcgfsaq tvydqwfitl fnivytslpv lamgifdqdv sdqnsvdcpq
      841 lykpgqlnll fnkrkfficv lhgiytslvl ffipygafyn vagedgqhia dyqsfavtma
      901 tslvivvsvq ialdtsywtf inhvfiwgsi aiyfsilftm hsngifgifp nqfpfvgnar
      961 hsltqkciwl villttvasv mpvvafrflk vdlyptlsdq irrwqkaqkk arppssrrpr
     1021 trrsssrrsg yafahqegyg elitsgknmr aknppptsgl ekthynstsw ienlckkttd
     1081 tvssfsqdkt vkl
//
LOCUS       XP_011520364            1093 aa            linear   PRI 05-AUG-2025
DEFINITION  putative phospholipid-transporting ATPase IM isoform X17 [Homo
            sapiens].
ACCESSION   XP_011520364
VERSION     XP_011520364.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522062.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1093
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1093
                     /product="putative phospholipid-transporting ATPase IM
                     isoform X17"
                     /calculated_mol_wt=123833
     Region          2..874
                     /region_name="P-type_ATPase_APLT_Dnf-like"
                     /note="Aminophospholipid translocases (APLTs), similar to
                     Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2,
                     -10D, -11B, -11C; cd02073"
                     /db_xref="CDD:319770"
     Site            order(293..295,438,461..463,528,575..577,690,693,696,716,
                     719)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:319770"
     CDS             1..1093
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /coded_by="XM_011522062.1:108..3389"
                     /db_xref="GeneID:79895"
                     /db_xref="HGNC:HGNC:13536"
                     /db_xref="MIM:609123"
ORIGIN      
        1 mnvkvgdiik lennqfvaad llllssseph glcyvetael dgslccykdv pwvecqlfga
       61 qealptflkq etnlkvrhal svtselgadi srlagfdgiv vcevpnnkld kfmgilswkd
      121 skhslnneki ilrgcilrnt swcfgmvifa gpdtklmqns gktkfkrtsi drlmntlvlw
      181 ifgfliclgi ilaignsiwe sqtgdqfrtf lfwnegekss vfsgfltfws yiiilntvvp
      241 islyvsvevi rlghsyfinw drkmyysrka ipavartttl neelgqieyi fsdktgtltq
      301 nimtfkrcsi ngriygevhd dldqkteitq ekepvdfsvk sqadrefqff dhhlmesikm
      361 gdpkvheflr llalchtvms eensageliy qvqspdegal vtaarnfgfi fksrtpetit
      421 ieelgtlvty qllafldfnn trkrmsvivr npegqiklys kgadtilfek lhpsnevlls
      481 ltsdhlsefa geglrtlaia yrdlddkyfk ewhkmledan aateerderi aglyeeierd
      541 lmllgatave dklqegviet vtslslanik iwvltgdkqe tainigyacn mltddmndvf
      601 viagnnavev reelrkakqn lfgqnrnfsn ghvvcekkqq leldsiveet itgdyaliin
      661 ghslahales dvkndllela cmcktviccr vtplqkaqvv elvkkyrnav tlaigdgand
      721 vsmiksahig vgisgqeglq avlasdysfa qfrylqrlll vhgrwsyfrm ckflcyffyk
      781 nfaftlvhfw fgffcgfsaq tvydqwfitl fnivytslpv lamgifdqdv sdqnsvdcpq
      841 lykpgqlnll fnkrkfficv lhgiytslvl ffipygafyn vagedgqhia dyqsfavtma
      901 tslvivvsvq ialdtsywtf inhvfiwgsi aiyfsilftm hsngifgifp nqfpfvgnar
      961 hsltqkciwl villttvasv mpvvafrflk vdlyptlsdq irrwqkaqkk arppssrrpr
     1021 trrsssrrsg yafahqegyg elitsgknmr aknppptsgl ekthynstsw ienlckkttd
     1081 tvssfsqdkt vkl
//
LOCUS       XP_011520365            1093 aa            linear   PRI 05-AUG-2025
DEFINITION  putative phospholipid-transporting ATPase IM isoform X17 [Homo
            sapiens].
ACCESSION   XP_011520365
VERSION     XP_011520365.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522063.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1093
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1093
                     /product="putative phospholipid-transporting ATPase IM
                     isoform X17"
                     /calculated_mol_wt=123833
     Region          2..874
                     /region_name="P-type_ATPase_APLT_Dnf-like"
                     /note="Aminophospholipid translocases (APLTs), similar to
                     Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2,
                     -10D, -11B, -11C; cd02073"
                     /db_xref="CDD:319770"
     Site            order(293..295,438,461..463,528,575..577,690,693,696,716,
                     719)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:319770"
     CDS             1..1093
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /coded_by="XM_011522063.1:90..3371"
                     /db_xref="GeneID:79895"
                     /db_xref="HGNC:HGNC:13536"
                     /db_xref="MIM:609123"
ORIGIN      
        1 mnvkvgdiik lennqfvaad llllssseph glcyvetael dgslccykdv pwvecqlfga
       61 qealptflkq etnlkvrhal svtselgadi srlagfdgiv vcevpnnkld kfmgilswkd
      121 skhslnneki ilrgcilrnt swcfgmvifa gpdtklmqns gktkfkrtsi drlmntlvlw
      181 ifgfliclgi ilaignsiwe sqtgdqfrtf lfwnegekss vfsgfltfws yiiilntvvp
      241 islyvsvevi rlghsyfinw drkmyysrka ipavartttl neelgqieyi fsdktgtltq
      301 nimtfkrcsi ngriygevhd dldqkteitq ekepvdfsvk sqadrefqff dhhlmesikm
      361 gdpkvheflr llalchtvms eensageliy qvqspdegal vtaarnfgfi fksrtpetit
      421 ieelgtlvty qllafldfnn trkrmsvivr npegqiklys kgadtilfek lhpsnevlls
      481 ltsdhlsefa geglrtlaia yrdlddkyfk ewhkmledan aateerderi aglyeeierd
      541 lmllgatave dklqegviet vtslslanik iwvltgdkqe tainigyacn mltddmndvf
      601 viagnnavev reelrkakqn lfgqnrnfsn ghvvcekkqq leldsiveet itgdyaliin
      661 ghslahales dvkndllela cmcktviccr vtplqkaqvv elvkkyrnav tlaigdgand
      721 vsmiksahig vgisgqeglq avlasdysfa qfrylqrlll vhgrwsyfrm ckflcyffyk
      781 nfaftlvhfw fgffcgfsaq tvydqwfitl fnivytslpv lamgifdqdv sdqnsvdcpq
      841 lykpgqlnll fnkrkfficv lhgiytslvl ffipygafyn vagedgqhia dyqsfavtma
      901 tslvivvsvq ialdtsywtf inhvfiwgsi aiyfsilftm hsngifgifp nqfpfvgnar
      961 hsltqkciwl villttvasv mpvvafrflk vdlyptlsdq irrwqkaqkk arppssrrpr
     1021 trrsssrrsg yafahqegyg elitsgknmr aknppptsgl ekthynstsw ienlckkttd
     1081 tvssfsqdkt vkl
//
LOCUS       XP_047289048            1083 aa            linear   PRI 05-AUG-2025
DEFINITION  putative phospholipid-transporting ATPase IM isoform X18 [Homo
            sapiens].
ACCESSION   XP_047289048
VERSION     XP_047289048.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433092.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1083
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1083
                     /product="putative phospholipid-transporting ATPase IM
                     isoform X18"
                     /calculated_mol_wt=122799
     Region          12..864
                     /region_name="P-type_ATPase_APLT_Dnf-like"
                     /note="Aminophospholipid translocases (APLTs), similar to
                     Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2,
                     -10D, -11B, -11C; cd02073"
                     /db_xref="CDD:319770"
     Site            order(283..285,428,451..453,518,565..567,680,683,686,706,
                     709)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:319770"
     CDS             1..1083
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /coded_by="XM_047433092.1:95..3346"
                     /db_xref="GeneID:79895"
                     /db_xref="HGNC:HGNC:13536"
                     /db_xref="MIM:609123"
ORIGIN      
        1 mtvnimksss mrlqnekwmn vkvgdiikle nnqfvaadll llsssephgl cyvetaeldg
       61 etnlkvrhal svtselgadi srlagfdgiv vcevpnnkld kfmgilswkd skhslnneki
      121 ilrgcilrnt swcfgmvifa gpdtklmqns gktkfkrtsi drlmntlvlw ifgfliclgi
      181 ilaignsiwe sqtgdqfrtf lfwnegekss vfsgfltfws yiiilntvvp islyvsvevi
      241 rlghsyfinw drkmyysrka ipavartttl neelgqieyi fsdktgtltq nimtfkrcsi
      301 ngriygevhd dldqkteitq ekepvdfsvk sqadrefqff dhhlmesikm gdpkvheflr
      361 llalchtvms eensageliy qvqspdegal vtaarnfgfi fksrtpetit ieelgtlvty
      421 qllafldfnn trkrmsvivr npegqiklys kgadtilfek lhpsnevlls ltsdhlsefa
      481 geglrtlaia yrdlddkyfk ewhkmledan aateerderi aglyeeierd lmllgatave
      541 dklqegviet vtslslanik iwvltgdkqe tainigyacn mltddmndvf viagnnavev
      601 reelrkakqn lfgqnrnfsn ghvvcekkqq leldsiveet itgdyaliin ghslahales
      661 dvkndllela cmcktviccr vtplqkaqvv elvkkyrnav tlaigdgand vsmiksahig
      721 vgisgqeglq avlasdysfa qfrylqrlll vhgrwsyfrm ckflcyffyk nfaftlvhfw
      781 fgffcgfsaq tvydqwfitl fnivytslpv lamgifdqdv sdqnsvdcpq lykpgqlnll
      841 fnkrkfficv lhgiytslvl ffipygafyn vagedgqhia dyqsfavtma tslvivvsvq
      901 ialdtsywtf inhvfiwgsi aiyfsilftm hsngifgifp nqfpfvgnar hsltqkciwl
      961 villttvasv mpvvafrflk vdlyptlsdq irrwqkaqkk arppssrrpr trrsssrrsg
     1021 yafahqegyg elitsgknmr aknppptsgl ekthynstsw ienlckkttd tvssfsqdkt
     1081 vkl
//
LOCUS       XP_047289049            1076 aa            linear   PRI 05-AUG-2025
DEFINITION  putative phospholipid-transporting ATPase IM isoform X19 [Homo
            sapiens].
ACCESSION   XP_047289049
VERSION     XP_047289049.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433093.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1076
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1076
                     /product="putative phospholipid-transporting ATPase IM
                     isoform X19"
                     /calculated_mol_wt=122608
     Region          30..857
                     /region_name="P-type_ATPase_APLT_Dnf-like"
                     /note="Aminophospholipid translocases (APLTs), similar to
                     Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2,
                     -10D, -11B, -11C; cd02073"
                     /db_xref="CDD:319770"
     Site            order(339..341,428,444..446,511,558..560,673,676,679,699,
                     702)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:319770"
     CDS             1..1076
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /coded_by="XM_047433093.1:110..3340"
                     /db_xref="GeneID:79895"
                     /db_xref="HGNC:HGNC:13536"
                     /db_xref="MIM:609123"
ORIGIN      
        1 mfcsekklre verivkandr eynekfqyad nrihtskyni ltflpinlfe qfqrvanayf
       61 lcllilqlip eissltwftt ivplvlvitm tavkdatddy frhksdnqvn nrqsevlins
      121 klqnekwmnv kvgdiiklen nqfvaadlll lsssephglc yvetaeldge tnlkvrhals
      181 vtselgadis rlagfdgpdt klmqnsgktk fkrtsidrlm ntlvlwifgf liclgiilai
      241 gnsiwesqtg dqfrtflfwn egekssvfsg fltfwsyiii lntvvpisly vsvevirlgh
      301 syfinwdrkm yysrkaipav artttlneel gqieyifsdk tgtltqnimt fkrcsingri
      361 ygevhddldq kteitqekep vdfsvksqad refqffdhhl mesikmgdpk vheflrllal
      421 chtvmseens avrnpegqik lyskgadtil feklhpsnev llsltsdhls efageglrtl
      481 aiayrdlddk yfkewhkmle danaateerd eriaglyeei erdlmllgat avedklqegv
      541 ietvtslsla nikiwvltgd kqetainigy acnmltddmn dvfviagnna vevreelrka
      601 kqnlfgqnrn fsnghvvcek kqqleldsiv eetitgdyal iinghslaha lesdvkndll
      661 elacmcktvi ccrvtplqka qvvelvkkyr navtlaigdg andvsmiksa higvgisgqe
      721 glqavlasdy sfaqfrylqr lllvhgrwsy frmckflcyf fyknfaftlv hfwfgffcgf
      781 saqtvydqwf itlfnivyts lpvlamgifd qdvsdqnsvd cpqlykpgql nllfnkrkff
      841 icvlhgiyts lvlffipyga fynvagedgq hiadyqsfav tmatslvivv svqialdtsy
      901 wtfinhvfiw gsiaiyfsil ftmhsngifg ifpnqfpfvg narhsltqkc iwlvillttv
      961 asvmpvvafr flkvdlyptl sdqirrwqka qkkarppssr rprtrrsssr rsgyafahqe
     1021 gygelitsgk nmraknpppt sglekthyns tswienlckk ttdtvssfsq dktvkl
//
LOCUS       XP_024305836            1074 aa            linear   PRI 05-AUG-2025
DEFINITION  putative phospholipid-transporting ATPase IM isoform X20 [Homo
            sapiens].
ACCESSION   XP_024305836
VERSION     XP_024305836.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024450068.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1074
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1074
                     /product="putative phospholipid-transporting ATPase IM
                     isoform X20"
                     /calculated_mol_wt=121927
     Region          67..1038
                     /region_name="P-type_ATPase_APLT_Dnf-like"
                     /note="Aminophospholipid translocases (APLTs), similar to
                     Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2,
                     -10D, -11B, -11C; cd02073"
                     /db_xref="CDD:319770"
     Site            order(457..459,602,625..627,692,739..741,854,857,860,880,
                     883)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:319770"
     CDS             1..1074
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /coded_by="XM_024450068.2:206..3430"
                     /db_xref="GeneID:79895"
                     /db_xref="HGNC:HGNC:13536"
                     /db_xref="MIM:609123"
ORIGIN      
        1 mkddffftlt tfrggasvsg gisvghllrp gersgiimfc sekklrever ivkandreyn
       61 ekfqyadnri htskyniltf lpinlfeqfq rvanayflcl lilqlipeis sltwfttivp
      121 lvlvitmtav kdatddyfrh ksdnqvnnrq sevlinsklq nekwmnvkvg diiklennqf
      181 vaadllllss sephglcyve taeldgslcc ykdvpwvecq lfgaqealpt flkqetnlkv
      241 rhalsvtsel gadisrlagf dgivvcevpn nkldkfmgil swkdskhsln nekiilrgci
      301 lrntswcfgm vifagpdtkl mqnsgktkfk rtsidrlmnt lvlwifgfli clgiilaign
      361 siwesqtgdq frtflfwneg ekssvfsgfl tfwsyiiiln tvvpislyvs vevirlghsy
      421 finwdrkmyy srkaipavar tttlneelgq ieyifsdktg tltqnimtfk rcsingriyg
      481 evhddldqkt eitqekepvd fsvksqadre fqffdhhlme sikmgdpkvh eflrllalch
      541 tvmseensag eliyqvqspd egalvtaarn fgfifksrtp etitieelgt lvtyqllafl
      601 dfnntrkrms vivrnpegqi klyskgadti lfeklhpsne vllsltsdhl sefageglrt
      661 laiayrdldd kyfkewhkml edanaateer deriaglyee ierdlmllga tavedklqeg
      721 vietvtslsl anikiwvltg dkqetainig yacnmltddm ndvfviagnn avevreelrk
      781 akqnlfgqnr nfsnghvvce kkqqleldsi veetitgdya liinghslah alesdvkndl
      841 lelacmcktv iccrvtplqk aqvvelvkky rnavtlaigd gandvsmiks ahigvgisgq
      901 eglqavlasd ysfaqfrylq rlllvhgrws yfrmckflcy ffyknfaftl vhfwfgffcg
      961 fsaqtvydqw fitlfnivyt slpvlamgif dqdvsdqnsv dcpqlykpgq lnllfnkrkf
     1021 ficvlhgiyt slvlffipyg afynvagedg qhiadyqsfa vtmatslviv vsvq
//
LOCUS       XP_047289050            1058 aa            linear   PRI 05-AUG-2025
DEFINITION  putative phospholipid-transporting ATPase IM isoform X21 [Homo
            sapiens].
ACCESSION   XP_047289050
VERSION     XP_047289050.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433094.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1058
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1058
                     /product="putative phospholipid-transporting ATPase IM
                     isoform X21"
                     /calculated_mol_wt=120428
     Region          31..839
                     /region_name="Haloacid Dehalogenase-like Hydrolases"
                     /note="The haloacid dehalogenase (HAD) superfamily
                     includes carbon and phosphorus hydrolases such as
                     2-haloalkonoate dehalogenase, epoxide hydrolase,
                     phosphoserine phosphatase, phosphomannomutase,
                     phosphoglycolate phosphatase, P-type ATPase, among others.
                     These...; cl21460"
                     /db_xref="CDD:473868"
     Site            order(321..325,540..541,661,680..681,684..685)
                     /site_type="active"
                     /db_xref="CDD:319763"
     CDS             1..1058
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /coded_by="XM_047433094.1:110..3286"
                     /db_xref="GeneID:79895"
                     /db_xref="HGNC:HGNC:13536"
                     /db_xref="MIM:609123"
ORIGIN      
        1 mfcsekklre verivkandr eynekfqyaf rhksdnqvnn rqsevlinsk lqnekwmnvk
       61 vgdiiklenn qfvaadllll sssephglcy vetaeldget nlkvrhalsv tselgadisr
      121 lagfdgivvc evpnnkldkf mgilswkdsk hslnnekiil rgcilrntsw cfgmvifagp
      181 dtklmqnsgk tkfkrtsidr lmntlvlwif gfliclgiil aignsiwesq tgdqfrtflf
      241 wnegekssvf sgfltfwsyi iilntvvpis lyvsvevirl ghsyfinwdr kmyysrkaip
      301 avartttlne elgqieyifs dktgtltqni mtfkrcsing riygevhddl dqkteitqek
      361 epvdfsvksq adrefqffdh hlmesikmgd pkvheflrll alchtvmsee nsavrnpegq
      421 iklyskgadt ilfeklhpsn evllsltsdh lsefageglr tlaiayrdld dkyfkewhkm
      481 ledanaatee rderiaglye eierdlmllg atavedklqe gvietvtsls lanikiwvlt
      541 gdkqetaini gyacnmltdd mndvfviagn navevreelr kakqnlfgqn rnfsnghvvc
      601 ekkqqlelds iveetitgdy aliinghsla halesdvknd llelacmckt viccrvtplq
      661 kaqvvelvkk yrnavtlaig dgandvsmik sahigvgisg qeglqavlas dysfaqfryl
      721 qrlllvhgrw syfrmckflc yffyknfaft lvhfwfgffc gfsaqtvydq wfitlfnivy
      781 tslpvlamgi fdqdvsdqns vdcpqlykpg qlnllfnkrk fficvlhgiy tslvlffipy
      841 gafynvaged gqhiadyqsf avtmatslvi vvsvqialdt sywtfinhvf iwgsiaiyfs
      901 ilftmhsngi fgifpnqfpf vgnarhsltq kciwlvillt tvasvmpvva frflkvdlyp
      961 tlsdqirrwq kaqkkarpps srrprtrrss srrsgyafah qegygelits gknmraknpp
     1021 ptsglekthy nstswienlc kkttdtvssf sqdktvkl
//
LOCUS       XP_047289052            1058 aa            linear   PRI 05-AUG-2025
DEFINITION  putative phospholipid-transporting ATPase IM isoform X21 [Homo
            sapiens].
ACCESSION   XP_047289052
VERSION     XP_047289052.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433096.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1058
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1058
                     /product="putative phospholipid-transporting ATPase IM
                     isoform X21"
                     /calculated_mol_wt=120428
     Region          31..839
                     /region_name="Haloacid Dehalogenase-like Hydrolases"
                     /note="The haloacid dehalogenase (HAD) superfamily
                     includes carbon and phosphorus hydrolases such as
                     2-haloalkonoate dehalogenase, epoxide hydrolase,
                     phosphoserine phosphatase, phosphomannomutase,
                     phosphoglycolate phosphatase, P-type ATPase, among others.
                     These...; cl21460"
                     /db_xref="CDD:473868"
     Site            order(321..325,540..541,661,680..681,684..685)
                     /site_type="active"
                     /db_xref="CDD:319763"
     CDS             1..1058
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /coded_by="XM_047433096.1:175..3351"
                     /db_xref="GeneID:79895"
                     /db_xref="HGNC:HGNC:13536"
                     /db_xref="MIM:609123"
ORIGIN      
        1 mfcsekklre verivkandr eynekfqyaf rhksdnqvnn rqsevlinsk lqnekwmnvk
       61 vgdiiklenn qfvaadllll sssephglcy vetaeldget nlkvrhalsv tselgadisr
      121 lagfdgivvc evpnnkldkf mgilswkdsk hslnnekiil rgcilrntsw cfgmvifagp
      181 dtklmqnsgk tkfkrtsidr lmntlvlwif gfliclgiil aignsiwesq tgdqfrtflf
      241 wnegekssvf sgfltfwsyi iilntvvpis lyvsvevirl ghsyfinwdr kmyysrkaip
      301 avartttlne elgqieyifs dktgtltqni mtfkrcsing riygevhddl dqkteitqek
      361 epvdfsvksq adrefqffdh hlmesikmgd pkvheflrll alchtvmsee nsavrnpegq
      421 iklyskgadt ilfeklhpsn evllsltsdh lsefageglr tlaiayrdld dkyfkewhkm
      481 ledanaatee rderiaglye eierdlmllg atavedklqe gvietvtsls lanikiwvlt
      541 gdkqetaini gyacnmltdd mndvfviagn navevreelr kakqnlfgqn rnfsnghvvc
      601 ekkqqlelds iveetitgdy aliinghsla halesdvknd llelacmckt viccrvtplq
      661 kaqvvelvkk yrnavtlaig dgandvsmik sahigvgisg qeglqavlas dysfaqfryl
      721 qrlllvhgrw syfrmckflc yffyknfaft lvhfwfgffc gfsaqtvydq wfitlfnivy
      781 tslpvlamgi fdqdvsdqns vdcpqlykpg qlnllfnkrk fficvlhgiy tslvlffipy
      841 gafynvaged gqhiadyqsf avtmatslvi vvsvqialdt sywtfinhvf iwgsiaiyfs
      901 ilftmhsngi fgifpnqfpf vgnarhsltq kciwlvillt tvasvmpvva frflkvdlyp
      961 tlsdqirrwq kaqkkarpps srrprtrrss srrsgyafah qegygelits gknmraknpp
     1021 ptsglekthy nstswienlc kkttdtvssf sqdktvkl
//
LOCUS       XP_024305837            1008 aa            linear   PRI 05-AUG-2025
DEFINITION  putative phospholipid-transporting ATPase IM isoform X22 [Homo
            sapiens].
ACCESSION   XP_024305837
VERSION     XP_024305837.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024450069.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1008
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1008
                     /product="putative phospholipid-transporting ATPase IM
                     isoform X22"
                     /calculated_mol_wt=114569
     Region          7..789
                     /region_name="Haloacid Dehalogenase-like Hydrolases"
                     /note="The haloacid dehalogenase (HAD) superfamily
                     includes carbon and phosphorus hydrolases such as
                     2-haloalkonoate dehalogenase, epoxide hydrolase,
                     phosphoserine phosphatase, phosphomannomutase,
                     phosphoglycolate phosphatase, P-type ATPase, among others.
                     These...; cl21460"
                     /db_xref="CDD:473868"
     Site            order(208..212,490..491,611,630..631,634..635)
                     /site_type="active"
                     /db_xref="CDD:319763"
     CDS             1..1008
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /coded_by="XM_024450069.1:16..3042"
                     /db_xref="GeneID:79895"
                     /db_xref="HGNC:HGNC:13536"
                     /db_xref="MIM:609123"
ORIGIN      
        1 mvsvmlklls lmgivvcevp nnkldkfmgi lswkdskhsl nnekiilrgc ilrntswcfg
       61 mvifagpdtk lmqnsgktkf krtsidrlmn tlvlwifgfl iclgiilaig nsiwesqtgd
      121 qfrtflfwne gekssvfsgf ltfwsyiiil ntvvpislyv svevirlghs yfinwdrkmy
      181 ysrkaipava rtttlneelg qieyifsdkt gtltqnimtf krcsingriy gevhddldqk
      241 teitqekepv dfsvksqadr efqffdhhlm esikmgdpkv heflrllalc htvmseensa
      301 geliyqvqsp degalvtaar nfgfifksrt petitieelg tlvtyqllaf ldfnntrkrm
      361 svivrnpegq iklyskgadt ilfeklhpsn evllsltsdh lsefageglr tlaiayrdld
      421 dkyfkewhkm ledanaatee rderiaglye eierdlmllg atavedklqe gvietvtsls
      481 lanikiwvlt gdkqetaini gyacnmltdd mndvfviagn navevreelr kakqnlfgqn
      541 rnfsnghvvc ekkqqlelds iveetitgdy aliinghsla halesdvknd llelacmckt
      601 viccrvtplq kaqvvelvkk yrnavtlaig dgandvsmik sahigvgisg qeglqavlas
      661 dysfaqfryl qrlllvhgrw syfrmckflc yffyknfaft lvhfwfgffc gfsaqtvydq
      721 wfitlfnivy tslpvlamgi fdqdvsdqns vdcpqlykpg qlnllfnkrk fficvlhgiy
      781 tslvlffipy gafynvaged gqhiadyqsf avtmatslvi vvsvqialdt sywtfinhvf
      841 iwgsiaiyfs ilftmhsngi fgifpnqfpf vgnarhsltq kciwlvillt tvasvmpvva
      901 frflkvdlyp tlsdqirrwq kaqkkarpps srrprtrrss srrsgyafah qegygelits
      961 gknmraknpp ptsglekthy nstswienlc kkttdtvssf sqdktvkl
//
LOCUS       XP_047289053             981 aa            linear   PRI 05-AUG-2025
DEFINITION  putative phospholipid-transporting ATPase IM isoform X23 [Homo
            sapiens].
ACCESSION   XP_047289053
VERSION     XP_047289053.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433097.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..981
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..981
                     /product="putative phospholipid-transporting ATPase IM
                     isoform X23"
                     /calculated_mol_wt=111565
     Region          <1..762
                     /region_name="Haloacid Dehalogenase-like Hydrolases"
                     /note="The haloacid dehalogenase (HAD) superfamily
                     includes carbon and phosphorus hydrolases such as
                     2-haloalkonoate dehalogenase, epoxide hydrolase,
                     phosphoserine phosphatase, phosphomannomutase,
                     phosphoglycolate phosphatase, P-type ATPase, among others.
                     These...; cl21460"
                     /db_xref="CDD:473868"
     Site            order(181..185,463..464,584,603..604,607..608)
                     /site_type="active"
                     /db_xref="CDD:319770"
     CDS             1..981
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /coded_by="XM_047433097.1:213..3158"
                     /db_xref="GeneID:79895"
                     /db_xref="HGNC:HGNC:13536"
                     /db_xref="MIM:609123"
ORIGIN      
        1 mgilswkdsk hslnnekiil rgcilrntsw cfgmvifagp dtklmqnsgk tkfkrtsidr
       61 lmntlvlwif gfliclgiil aignsiwesq tgdqfrtflf wnegekssvf sgfltfwsyi
      121 iilntvvpis lyvsvevirl ghsyfinwdr kmyysrkaip avartttlne elgqieyifs
      181 dktgtltqni mtfkrcsing riygevhddl dqkteitqek epvdfsvksq adrefqffdh
      241 hlmesikmgd pkvheflrll alchtvmsee nsageliyqv qspdegalvt aarnfgfifk
      301 srtpetitie elgtlvtyql lafldfnntr krmsvivrnp egqiklyskg adtilfeklh
      361 psnevllslt sdhlsefage glrtlaiayr dlddkyfkew hkmledanaa teerderiag
      421 lyeeierdlm llgatavedk lqegvietvt slslanikiw vltgdkqeta inigyacnml
      481 tddmndvfvi agnnavevre elrkakqnlf gqnrnfsngh vvcekkqqle ldsiveetit
      541 gdyaliingh slahalesdv kndllelacm cktviccrvt plqkaqvvel vkkyrnavtl
      601 aigdgandvs miksahigvg isgqeglqav lasdysfaqf rylqrlllvh grwsyfrmck
      661 flcyffyknf aftlvhfwfg ffcgfsaqtv ydqwfitlfn ivytslpvla mgifdqdvsd
      721 qnsvdcpqly kpgqlnllfn krkfficvlh giytslvlff ipygafynva gedgqhiady
      781 qsfavtmats lvivvsvqia ldtsywtfin hvfiwgsiai yfsilftmhs ngifgifpnq
      841 fpfvgnarhs ltqkciwlvi llttvasvmp vvafrflkvd lyptlsdqir rwqkaqkkar
      901 ppssrrprtr rsssrrsgya fahqegygel itsgknmrak nppptsglek thynstswie
      961 nlckkttdtv ssfsqdktvk l
//
LOCUS       XP_047289054             981 aa            linear   PRI 05-AUG-2025
DEFINITION  putative phospholipid-transporting ATPase IM isoform X23 [Homo
            sapiens].
ACCESSION   XP_047289054
VERSION     XP_047289054.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433098.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..981
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..981
                     /product="putative phospholipid-transporting ATPase IM
                     isoform X23"
                     /calculated_mol_wt=111565
     Region          <1..762
                     /region_name="Haloacid Dehalogenase-like Hydrolases"
                     /note="The haloacid dehalogenase (HAD) superfamily
                     includes carbon and phosphorus hydrolases such as
                     2-haloalkonoate dehalogenase, epoxide hydrolase,
                     phosphoserine phosphatase, phosphomannomutase,
                     phosphoglycolate phosphatase, P-type ATPase, among others.
                     These...; cl21460"
                     /db_xref="CDD:473868"
     Site            order(181..185,463..464,584,603..604,607..608)
                     /site_type="active"
                     /db_xref="CDD:319770"
     CDS             1..981
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /coded_by="XM_047433098.1:4794..7739"
                     /db_xref="GeneID:79895"
                     /db_xref="HGNC:HGNC:13536"
                     /db_xref="MIM:609123"
ORIGIN      
        1 mgilswkdsk hslnnekiil rgcilrntsw cfgmvifagp dtklmqnsgk tkfkrtsidr
       61 lmntlvlwif gfliclgiil aignsiwesq tgdqfrtflf wnegekssvf sgfltfwsyi
      121 iilntvvpis lyvsvevirl ghsyfinwdr kmyysrkaip avartttlne elgqieyifs
      181 dktgtltqni mtfkrcsing riygevhddl dqkteitqek epvdfsvksq adrefqffdh
      241 hlmesikmgd pkvheflrll alchtvmsee nsageliyqv qspdegalvt aarnfgfifk
      301 srtpetitie elgtlvtyql lafldfnntr krmsvivrnp egqiklyskg adtilfeklh
      361 psnevllslt sdhlsefage glrtlaiayr dlddkyfkew hkmledanaa teerderiag
      421 lyeeierdlm llgatavedk lqegvietvt slslanikiw vltgdkqeta inigyacnml
      481 tddmndvfvi agnnavevre elrkakqnlf gqnrnfsngh vvcekkqqle ldsiveetit
      541 gdyaliingh slahalesdv kndllelacm cktviccrvt plqkaqvvel vkkyrnavtl
      601 aigdgandvs miksahigvg isgqeglqav lasdysfaqf rylqrlllvh grwsyfrmck
      661 flcyffyknf aftlvhfwfg ffcgfsaqtv ydqwfitlfn ivytslpvla mgifdqdvsd
      721 qnsvdcpqly kpgqlnllfn krkfficvlh giytslvlff ipygafynva gedgqhiady
      781 qsfavtmats lvivvsvqia ldtsywtfin hvfiwgsiai yfsilftmhs ngifgifpnq
      841 fpfvgnarhs ltqkciwlvi llttvasvmp vvafrflkvd lyptlsdqir rwqkaqkkar
      901 ppssrrprtr rsssrrsgya fahqegygel itsgknmrak nppptsglek thynstswie
      961 nlckkttdtv ssfsqdktvk l
//
LOCUS       XP_011520371             937 aa            linear   PRI 05-AUG-2025
DEFINITION  putative phospholipid-transporting ATPase IM isoform X24 [Homo
            sapiens].
ACCESSION   XP_011520371
VERSION     XP_011520371.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522069.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..937
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..937
                     /product="putative phospholipid-transporting ATPase IM
                     isoform X24"
                     /calculated_mol_wt=106588
     Region          <1..718
                     /region_name="Haloacid Dehalogenase-like Hydrolases"
                     /note="The haloacid dehalogenase (HAD) superfamily
                     includes carbon and phosphorus hydrolases such as
                     2-haloalkonoate dehalogenase, epoxide hydrolase,
                     phosphoserine phosphatase, phosphomannomutase,
                     phosphoglycolate phosphatase, P-type ATPase, among others.
                     These...; cl21460"
                     /db_xref="CDD:473868"
     Site            order(137..141,419..420,540,559..560,563..564)
                     /site_type="active"
                     /db_xref="CDD:319770"
     CDS             1..937
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /coded_by="XM_011522069.2:80..2893"
                     /db_xref="GeneID:79895"
                     /db_xref="HGNC:HGNC:13536"
                     /db_xref="MIM:609123"
ORIGIN      
        1 mqnsgktkfk rtsidrlmnt lvlwifgfli clgiilaign siwesqtgdq frtflfwneg
       61 ekssvfsgfl tfwsyiiiln tvvpislyvs vevirlghsy finwdrkmyy srkaipavar
      121 tttlneelgq ieyifsdktg tltqnimtfk rcsingriyg evhddldqkt eitqekepvd
      181 fsvksqadre fqffdhhlme sikmgdpkvh eflrllalch tvmseensag eliyqvqspd
      241 egalvtaarn fgfifksrtp etitieelgt lvtyqllafl dfnntrkrms vivrnpegqi
      301 klyskgadti lfeklhpsne vllsltsdhl sefageglrt laiayrdldd kyfkewhkml
      361 edanaateer deriaglyee ierdlmllga tavedklqeg vietvtslsl anikiwvltg
      421 dkqetainig yacnmltddm ndvfviagnn avevreelrk akqnlfgqnr nfsnghvvce
      481 kkqqleldsi veetitgdya liinghslah alesdvkndl lelacmcktv iccrvtplqk
      541 aqvvelvkky rnavtlaigd gandvsmiks ahigvgisgq eglqavlasd ysfaqfrylq
      601 rlllvhgrws yfrmckflcy ffyknfaftl vhfwfgffcg fsaqtvydqw fitlfnivyt
      661 slpvlamgif dqdvsdqnsv dcpqlykpgq lnllfnkrkf ficvlhgiyt slvlffipyg
      721 afynvagedg qhiadyqsfa vtmatslviv vsvqialdts ywtfinhvfi wgsiaiyfsi
      781 lftmhsngif gifpnqfpfv gnarhsltqk ciwlvilltt vasvmpvvaf rflkvdlypt
      841 lsdqirrwqk aqkkarppss rrprtrrsss rrsgyafahq egygelitsg knmraknppp
      901 tsglekthyn stswienlck kttdtvssfs qdktvkl
//
LOCUS       XP_047289055             915 aa            linear   PRI 05-AUG-2025
DEFINITION  putative phospholipid-transporting ATPase IM isoform X25 [Homo
            sapiens].
ACCESSION   XP_047289055
VERSION     XP_047289055.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433099.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..915
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..915
                     /product="putative phospholipid-transporting ATPase IM
                     isoform X25"
                     /calculated_mol_wt=104281
     Region          30..899
                     /region_name="P-type_ATPase_APLT_Dnf-like"
                     /note="Aminophospholipid translocases (APLTs), similar to
                     Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2,
                     -10D, -11B, -11C; cd02073"
                     /db_xref="CDD:319770"
     Site            order(392..394,537,560..562,627,674..676,789,792,795,815,
                     818)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:319770"
     CDS             1..915
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /coded_by="XM_047433099.1:110..2857"
                     /db_xref="GeneID:79895"
                     /db_xref="HGNC:HGNC:13536"
                     /db_xref="MIM:609123"
ORIGIN      
        1 mfcsekklre verivkandr eynekfqyad nrihtskyni ltflpinlfe qfqrvanayf
       61 lcllilqlip eissltwftt ivplvlvitm tavkdatddy frhksdnqvn nrqsevlins
      121 klqnekwmnv kvgdiiklen nqfvaadlll lsssephglc yvetaeldge tnlkvrhals
      181 vtselgadis rlagfdgivv cevpnnkldk fmgilswkds khslnnekii lrgcilrnts
      241 wcfgmvifag pdtklmqnsg ktkfkrtsid rlmntlvlwi fgfliclgii laignsiwes
      301 qtgdqfrtfl fwnegekssv fsgfltfwsy iiilntvvpi slyvsvevir lghsyfinwd
      361 rkmyysrkai pavartttln eelgqieyif sdktgtltqn imtfkrcsin griygevhdd
      421 ldqkteitqe kepvdfsvks qadrefqffd hhlmesikmg dpkvheflrl lalchtvmse
      481 ensageliyq vqspdegalv taarnfgfif ksrtpetiti eelgtlvtyq llafldfnnt
      541 rkrmsvivrn pegqiklysk gadtilfekl hpsnevllsl tsdhlsefag eglrtlaiay
      601 rdlddkyfke whkmledana ateerderia glyeeierdl mllgataved klqegvietv
      661 tslslaniki wvltgdkqet ainigyacnm ltddmndvfv iagnnavevr eelrkakqnl
      721 fgqnrnfsng hvvcekkqql eldsiveeti tgdyaliing hslahalesd vkndllelac
      781 mcktviccrv tplqkaqvve lvkkyrnavt laigdgandv smiksahigv gisgqeglqa
      841 vlasdysfaq frylqrlllv hgrwsyfrmc kflcyffykn faftlvhfwf gffcgfsaqr
      901 rililqelri sgrqg
//
LOCUS       XP_047289056             782 aa            linear   PRI 05-AUG-2025
DEFINITION  putative phospholipid-transporting ATPase IM isoform X26 [Homo
            sapiens].
ACCESSION   XP_047289056
VERSION     XP_047289056.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433100.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..782
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..782
                     /product="putative phospholipid-transporting ATPase IM
                     isoform X26"
                     /calculated_mol_wt=88933
     Region          67..>769
                     /region_name="Haloacid Dehalogenase-like Hydrolases"
                     /note="The haloacid dehalogenase (HAD) superfamily
                     includes carbon and phosphorus hydrolases such as
                     2-haloalkonoate dehalogenase, epoxide hydrolase,
                     phosphoserine phosphatase, phosphomannomutase,
                     phosphoglycolate phosphatase, P-type ATPase, among others.
                     These...; cl21460"
                     /db_xref="CDD:473868"
     CDS             1..782
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /coded_by="XM_047433100.1:206..2554"
                     /db_xref="GeneID:79895"
                     /db_xref="HGNC:HGNC:13536"
                     /db_xref="MIM:609123"
ORIGIN      
        1 mkddffftlt tfrggasvsg gisvghllrp gersgiimfc sekklrever ivkandreyn
       61 ekfqyadnri htskyniltf lpinlfeqfq rvanayflcl lilqlipeis sltwfttivp
      121 lvlvitmtav kdatddyfrh ksdnqvnnrq sevlinsklq nekwmnvkvg diiklennqf
      181 vaadllllss sephglcyve taeldgslcc ykdvpwvecq lfgaqealpt flkqetnlkv
      241 rhalsvtsel gadisrlagf dgivvcevpn nkldkfmgil swkdskhsln nekiilrgci
      301 lrntswcfgm vifagpdtkl mqnsgktkfk rtsidrlmnt lvlwifgfli clgiilaign
      361 siwesqtgdq frtflfwneg ekssvfsgfl tfwsyiiiln tvvpislyvs vevirlghsy
      421 finwdrkmyy srkaipavar tttlneelgq ieyifsdktg tltqnimtfk rcsingriyg
      481 evhddldqkt eitqekepvd fsvksqadre fqffdhhlme sikmgdpkvh eflrllalch
      541 tvmseensag eliyqvqspd egalvtaarn fgfifksrtp etitieelgt lvtyqllafl
      601 dfnntrkrms vivrnpegqi klyskgadti lfeklhpsne vllsltsdhl sefageglrt
      661 laiayrdldd kyfkewhkml edanaateer deriaglyee ierdlmllga tavedklqeg
      721 vietvtslsl anikiwvltg dkqetainig yacnmltddm ndvfviagnn avevreelrl
      781 mp
//
LOCUS       XP_011520372             739 aa            linear   PRI 05-AUG-2025
DEFINITION  putative phospholipid-transporting ATPase IM isoform X27 [Homo
            sapiens].
ACCESSION   XP_011520372
VERSION     XP_011520372.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522070.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..739
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..739
                     /product="putative phospholipid-transporting ATPase IM
                     isoform X27"
                     /calculated_mol_wt=83521
     Region          <14..520
                     /region_name="Haloacid Dehalogenase-like Hydrolases"
                     /note="The haloacid dehalogenase (HAD) superfamily
                     includes carbon and phosphorus hydrolases such as
                     2-haloalkonoate dehalogenase, epoxide hydrolase,
                     phosphoserine phosphatase, phosphomannomutase,
                     phosphoglycolate phosphatase, P-type ATPase, among others.
                     These...; cl21460"
                     /db_xref="CDD:473868"
     CDS             1..739
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /coded_by="XM_011522070.2:93..2312"
                     /db_xref="GeneID:79895"
                     /db_xref="HGNC:HGNC:13536"
                     /db_xref="MIM:609123"
ORIGIN      
        1 mesikmgdpk vheflrllal chtvmseens ageliyqvqs pdegalvtaa rnfgfifksr
       61 tpetitieel gtlvtyqlla fldfnntrkr msvivrnpeg qiklyskgad tilfeklhps
      121 nevllsltsd hlsefagegl rtlaiayrdl ddkyfkewhk mledanaate erderiagly
      181 eeierdlmll gatavedklq egvietvtsl slanikiwvl tgdkqetain igyacnmltd
      241 dmndvfviag nnavevreel rkakqnlfgq nrnfsnghvv cekkqqleld siveetitgd
      301 yaliinghsl ahalesdvkn dllelacmck tviccrvtpl qkaqvvelvk kyrnavtlai
      361 gdgandvsmi ksahigvgis gqeglqavla sdysfaqfry lqrlllvhgr wsyfrmckfl
      421 cyffyknfaf tlvhfwfgff cgfsaqtvyd qwfitlfniv ytslpvlamg ifdqdvsdqn
      481 svdcpqlykp gqlnllfnkr kfficvlhgi ytslvlffip ygafynvage dgqhiadyqs
      541 favtmatslv ivvsvqiald tsywtfinhv fiwgsiaiyf silftmhsng ifgifpnqfp
      601 fvgnarhslt qkciwlvill ttvasvmpvv afrflkvdly ptlsdqirrw qkaqkkarpp
      661 ssrrprtrrs ssrrsgyafa hqegygelit sgknmraknp pptsglekth ynstswienl
      721 ckkttdtvss fsqdktvkl
//
LOCUS       XP_024305838             722 aa            linear   PRI 05-AUG-2025
DEFINITION  putative phospholipid-transporting ATPase IM isoform X28 [Homo
            sapiens].
ACCESSION   XP_024305838
VERSION     XP_024305838.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024450070.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..722
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..722
                     /product="putative phospholipid-transporting ATPase IM
                     isoform X28"
                     /calculated_mol_wt=82515
     Region          67..>706
                     /region_name="Haloacid Dehalogenase-like Hydrolases"
                     /note="The haloacid dehalogenase (HAD) superfamily
                     includes carbon and phosphorus hydrolases such as
                     2-haloalkonoate dehalogenase, epoxide hydrolase,
                     phosphoserine phosphatase, phosphomannomutase,
                     phosphoglycolate phosphatase, P-type ATPase, among others.
                     These...; cl21460"
                     /db_xref="CDD:473868"
     CDS             1..722
                     /gene="ATP8B4"
                     /gene_synonym="ATPIM"
                     /coded_by="XM_024450070.2:206..2374"
                     /db_xref="GeneID:79895"
                     /db_xref="HGNC:HGNC:13536"
                     /db_xref="MIM:609123"
ORIGIN      
        1 mkddffftlt tfrggasvsg gisvghllrp gersgiimfc sekklrever ivkandreyn
       61 ekfqyadnri htskyniltf lpinlfeqfq rvanayflcl lilqlipeis sltwfttivp
      121 lvlvitmtav kdatddyfrh ksdnqvnnrq sevlinsklq nekwmnvkvg diiklennqf
      181 vaadllllss sephglcyve taeldgslcc ykdvpwvecq lfgaqealpt flkqetnlkv
      241 rhalsvtsel gadisrlagf dgivvcevpn nkldkfmgil swkdskhsln nekiilrgci
      301 lrntswcfgm vifagpdtkl mqnsgktkfk rtsidrlmnt lvlwifgfli clgiilaign
      361 siwesqtgdq frtflfwneg ekssvfsgfl tfwsyiiiln tvvpislyvs vevirlghsy
      421 finwdrkmyy srkaipavar tttlneelgq ieyifsdktg tltqnimtfk rcsingriyg
      481 evhddldqkt eitqekepvd fsvksqadre fqffdhhlme sikmgdpkvh eflrllalch
      541 tvmseensag eliyqvqspd egalvtaarn fgfifksrtp etitieelgt lvtyqllafl
      601 dfnntrkrms vivrnpegqi klyskgadti lfeklhpsne vllsltsdhl sefageglrt
      661 laiayrdldd kyfkewhkml edanaateer deriaglyee ierdlmsrei cceewgyssk
      721 ps
//
LOCUS       XP_047289057             602 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 62 isoform X1 [Homo sapiens].
ACCESSION   XP_047289057
VERSION     XP_047289057.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433101.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..602
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..602
                     /product="transmembrane protein 62 isoform X1"
                     /calculated_mol_wt=68446
     Region          57..304
                     /region_name="MPP_TMEM62_N"
                     /note="Homo sapiens TMEM62, N-terminal metallophosphatase
                     domain; cd07401"
                     /db_xref="CDD:277346"
     Site            order(63,65,99,142..143,230,256)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:277346"
     Site            order(63,65,99,142,230,256)
                     /site_type="other"
                     /note="putative metal binding site [ion binding]"
                     /db_xref="CDD:277346"
     Region          <299..350
                     /region_name="Big_7"
                     /note="Bacterial Ig domain; pfam17957"
                     /db_xref="CDD:436171"
     CDS             1..602
                     /gene="TMEM62"
                     /coded_by="XM_047433101.1:218..2026"
                     /db_xref="GeneID:80021"
                     /db_xref="HGNC:HGNC:26269"
ORIGIN      
        1 maavlalrvv aglaaaalva mllehyglag qpsplprpap prrphpapgp gdsnifwglq
       61 isdihlsrfr dpgravdlek fcsetidiiq palvlatgdl tdaktkeqlg srqhevewqt
      121 yqgilkktrv mektkwldik gnhdafnips ldsiknyyrk ysavrrdgsf hyvhstpfgn
      181 ysficvdatv npgpkrpynf fgildkkkme ellllakess rsnhtiwfgh fttstilsps
      241 pgirsimryr ifafdhdlfs fadlifgkwp vvlitnpksl lyscgehepl erllhsthir
      301 vlafslssit svtvkidgvh lgqavhvsgp ifvlkwnprn yssgthniev ivqdsagrsk
      361 svhhifsvqe nnhlsfdpla sfilrtdhyi marvlfvliv lsqltiliif ryrgypelke
      421 psgfinltsf slhvlskini fyysvllltl ytvlgpwffg eiidgkfgcc fsfgifvngh
      481 flqgsitfii gilqlaffni plmaymcwsl lqrcfghnfr shlhqrkylk impvhllmll
      541 lyiwqvyscy flyatygtla flfsplrtwl tlltpvliry vwtlnstkfg ifmvqlkshl
      601 ss
//
LOCUS       XP_047289058             567 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 62 isoform X2 [Homo sapiens].
ACCESSION   XP_047289058
VERSION     XP_047289058.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433102.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..567
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..567
                     /product="transmembrane protein 62 isoform X2"
                     /calculated_mol_wt=64457
     Region          57..304
                     /region_name="MPP_TMEM62_N"
                     /note="Homo sapiens TMEM62, N-terminal metallophosphatase
                     domain; cd07401"
                     /db_xref="CDD:277346"
     Site            order(63,65,99,142..143,230,256)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:277346"
     Site            order(63,65,99,142,230,256)
                     /site_type="other"
                     /note="putative metal binding site [ion binding]"
                     /db_xref="CDD:277346"
     Region          <299..350
                     /region_name="Big_7"
                     /note="Bacterial Ig domain; pfam17957"
                     /db_xref="CDD:436171"
     CDS             1..567
                     /gene="TMEM62"
                     /coded_by="XM_047433102.1:218..1921"
                     /db_xref="GeneID:80021"
                     /db_xref="HGNC:HGNC:26269"
ORIGIN      
        1 maavlalrvv aglaaaalva mllehyglag qpsplprpap prrphpapgp gdsnifwglq
       61 isdihlsrfr dpgravdlek fcsetidiiq palvlatgdl tdaktkeqlg srqhevewqt
      121 yqgilkktrv mektkwldik gnhdafnips ldsiknyyrk ysavrrdgsf hyvhstpfgn
      181 ysficvdatv npgpkrpynf fgildkkkme ellllakess rsnhtiwfgh fttstilsps
      241 pgirsimryr ifafdhdlfs fadlifgkwp vvlitnpksl lyscgehepl erllhsthir
      301 vlafslssit svtvkidgvh lgqavhvsgp ifvlkwnprn yssgthniev ivqdsagrsk
      361 svhhifsvqe nnhlsfdpla sfilrtdhyi marvlfvliv lsqltiliif ryrgypelkg
      421 pwffgeiidg kfgccfsfgi fvnghflqgs itfiigilql affniplmay mcwsllqrcf
      481 ghnfrshlhq rkylkimpvh llmlllyiwq vyscyflyat ygtlaflfsp lrtwltlltp
      541 vliryvwtln stkfgifmvq lkshlss
//
LOCUS       XP_047289059             476 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 62 isoform X3 [Homo sapiens].
ACCESSION   XP_047289059
VERSION     XP_047289059.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433103.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 4% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..476
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..476
                     /product="transmembrane protein 62 isoform X3"
                     /calculated_mol_wt=54507
     Region          <28..213
                     /region_name="MPP_superfamily"
                     /note="metallophosphatase superfamily, metallophosphatase
                     domain; cl13995"
                     /db_xref="CDD:472684"
     Region          <208..259
                     /region_name="Big_7"
                     /note="Bacterial Ig domain; pfam17957"
                     /db_xref="CDD:436171"
     CDS             1..476
                     /gene="TMEM62"
                     /coded_by="XM_047433103.1:347..1777"
                     /db_xref="GeneID:80021"
                     /db_xref="HGNC:HGNC:26269"
ORIGIN      
        1 manlpgysee dkshgknqva gyqrkswkys avrrdgsfhy vhstpfgnys ficvdatvnp
       61 gpkrpynffg ildkkkmeel lllakessrs nhtiwfghft tstilspspg irsimssaia
      121 ylcghlhtlg glmpvlhtrh fqgtlelevg dwkdnrryri fafdhdlfsf adlifgkwpv
      181 vlitnpksll yscgeheple rllhsthirv lafslssits vtvkidgvhl gqavhvsgpi
      241 fvlkwnprny ssgthnievi vqdsagrsks vhhifsvqen nhlsfdplas filrtdhyim
      301 arvlfvlivl sqltiliifr yrgypelkgp wffgeiidgk fgccfsfgif vnghflqgsi
      361 tfiigilqla ffniplmaym cwsllqrcfg hnfrshlhqr kylkimpvhl lmlllyiwqv
      421 yscyflyaty gtlaflfspl rtwltlltpv liryvwtlns tkfgifmvql kshlss
//
LOCUS       XP_047289060             435 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 62 isoform X4 [Homo sapiens].
ACCESSION   XP_047289060
VERSION     XP_047289060.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433104.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 7% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..435
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..435
                     /product="transmembrane protein 62 isoform X4"
                     /calculated_mol_wt=49824
     Region          <1..137
                     /region_name="MPP_superfamily"
                     /note="metallophosphatase superfamily, metallophosphatase
                     domain; cl13995"
                     /db_xref="CDD:472684"
     Region          <132..183
                     /region_name="Big_7"
                     /note="Bacterial Ig domain; pfam17957"
                     /db_xref="CDD:436171"
     CDS             1..435
                     /gene="TMEM62"
                     /coded_by="XM_047433104.1:191..1498"
                     /db_xref="GeneID:80021"
                     /db_xref="HGNC:HGNC:26269"
ORIGIN      
        1 meellllake ssrsnhtiwf ghfttstils pspgirsims saiaylcghl htlgglmpvl
       61 htrhfqgtle levgdwkdnr ryrifafdhd lfsfadlifg kwpvvlitnp ksllyscgeh
      121 eplerllhst hirvlafsls sitsvtvkid gvhlgqavhv sgpifvlkwn prnyssgthn
      181 ievivqdsag rsksvhhifs vqennhlsfd plasfilrtd hyimarvlfv livlsqltil
      241 iifryrgype lkepsgfinl tsfslhvlsk inifyysvll ltlytvlgpw ffgeiidgkf
      301 gccfsfgifv nghflqgsit fiigilqlaf fniplmaymc wsllqrcfgh nfrshlhqrk
      361 ylkimpvhll mlllyiwqvy scyflyatyg tlaflfsplr twltlltpvl iryvwtlnst
      421 kfgifmvqlk shlss
//
LOCUS       XP_047289061             427 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 62 isoform X5 [Homo sapiens].
ACCESSION   XP_047289061
VERSION     XP_047289061.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433105.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..427
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..427
                     /product="transmembrane protein 62 isoform X5"
                     /calculated_mol_wt=49179
     Region          <95..129
                     /region_name="MPP_superfamily"
                     /note="metallophosphatase superfamily, metallophosphatase
                     domain; cl13995"
                     /db_xref="CDD:472684"
     Region          <124..175
                     /region_name="Big_7"
                     /note="Bacterial Ig domain; pfam17957"
                     /db_xref="CDD:436171"
     CDS             1..427
                     /gene="TMEM62"
                     /coded_by="XM_047433105.1:136..1419"
                     /db_xref="GeneID:80021"
                     /db_xref="HGNC:HGNC:26269"
ORIGIN      
        1 mmhsifqvwt asriitekdg galitgqgkq seqpynlvwt lynihysfsi trnpvnnegt
       61 lelevgdwkd nrryrifafd hdlfsfadli fgkwpvvlit npksllyscg eheplerllh
      121 sthirvlafs lssitsvtvk idgvhlgqav hvsgpifvlk wnprnyssgt hnievivqds
      181 agrsksvhhi fsvqennhls fdplasfilr tdhyimarvl fvlivlsqlt iliifryrgy
      241 pelkepsgfi nltsfslhvl skinifyysv llltlytvlg pwffgeiidg kfgccfsfgi
      301 fvnghflqgs itfiigilql affniplmay mcwsllqrcf ghnfrshlhq rkylkimpvh
      361 llmlllyiwq vyscyflyat ygtlaflfsp lrtwltlltp vliryvwtln stkfgifmvq
      421 lkshlss
//
LOCUS       XP_024305839             424 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 62 isoform X6 [Homo sapiens].
ACCESSION   XP_024305839
VERSION     XP_024305839.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024450071.2
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 20% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..424
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..424
                     /product="transmembrane protein 62 isoform X6"
                     /calculated_mol_wt=48857
     Region          <92..126
                     /region_name="MPP_superfamily"
                     /note="metallophosphatase superfamily, metallophosphatase
                     domain; cl13995"
                     /db_xref="CDD:472684"
     Region          <121..172
                     /region_name="Big_7"
                     /note="Bacterial Ig domain; pfam17957"
                     /db_xref="CDD:436171"
     CDS             1..424
                     /gene="TMEM62"
                     /coded_by="XM_024450071.2:496..1770"
                     /db_xref="GeneID:80021"
                     /db_xref="HGNC:HGNC:26269"
ORIGIN      
        1 mektkwldik gnhekdggal itgqgkqseq pynlvwtlyn ihysfsitrn pvnnegtlel
       61 evgdwkdnrr yrifafdhdl fsfadlifgk wpvvlitnpk sllyscgehe plerllhsth
      121 irvlafslss itsvtvkidg vhlgqavhvs gpifvlkwnp rnyssgthni evivqdsagr
      181 sksvhhifsv qennhlsfdp lasfilrtdh yimarvlfvl ivlsqltili ifryrgypel
      241 kepsgfinlt sfslhvlski nifyysvlll tlytvlgpwf fgeiidgkfg ccfsfgifvn
      301 ghflqgsitf iigilqlaff niplmaymcw sllqrcfghn frshlhqrky lkimpvhllm
      361 lllyiwqvys cyflyatygt laflfsplrt wltlltpvli ryvwtlnstk fgifmvqlks
      421 hlss
//
LOCUS       XP_024305840             371 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 62 isoform X7 [Homo sapiens].
ACCESSION   XP_024305840
VERSION     XP_024305840.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024450072.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..371
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..371
                     /product="transmembrane protein 62 isoform X7"
                     /calculated_mol_wt=41731
     Region          57..341
                     /region_name="MPP_TMEM62_N"
                     /note="Homo sapiens TMEM62, N-terminal metallophosphatase
                     domain; cd07401"
                     /db_xref="CDD:277346"
     Site            order(63,65,99,142..143,230,257,259)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:277346"
     Site            order(63,65,99,142,230,257,259)
                     /site_type="other"
                     /note="putative metal binding site [ion binding]"
                     /db_xref="CDD:277346"
     CDS             1..371
                     /gene="TMEM62"
                     /coded_by="XM_024450072.2:218..1333"
                     /db_xref="GeneID:80021"
                     /db_xref="HGNC:HGNC:26269"
ORIGIN      
        1 maavlalrvv aglaaaalva mllehyglag qpsplprpap prrphpapgp gdsnifwglq
       61 isdihlsrfr dpgravdlek fcsetidiiq palvlatgdl tdaktkeqlg srqhevewqt
      121 yqgilkktrv mektkwldik gnhdafnips ldsiknyyrk ysavrrdgsf hyvhstpfgn
      181 ysficvdatv npgpkrpynf fgildkkkme ellllakess rsnhtiwfgh fttstilsps
      241 pgirsimssa iaylcghlht lgglmpvlht rhfqgtlele vgdwkdnrry rifafdhdlf
      301 sfadlifgkw pvvlitnpks llyscgehep lerllhsthi rschtvfhgg ctilhshqqc
      361 irypitfnnr c
//
LOCUS       XP_011520386             641 aa            linear   PRI 05-AUG-2025
DEFINITION  ATP-dependent DNA helicase PIF1 isoform X1 [Homo sapiens].
ACCESSION   XP_011520386
VERSION     XP_011520386.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522084.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..641
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..641
                     /product="ATP-dependent DNA helicase PIF1 isoform X1"
                     /calculated_mol_wt=69668
     Region          <27..209
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          207..504
                     /region_name="PIF1"
                     /note="PIF1-like helicase; pfam05970"
                     /db_xref="CDD:428699"
     Site            order(211,229..236,306,346)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:350795"
     Region          <487..>640
                     /region_name="PRK13889"
                     /note="conjugal transfer relaxase TraA; Provisional"
                     /db_xref="CDD:237546"
     Region          <548..593
                     /region_name="SF1_C_RecD"
                     /note="C-terminal helicase domain of RecD family
                     helicases; cd18809"
                     /db_xref="CDD:350196"
     Site            559
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:350196"
     CDS             1..641
                     /gene="PIF1"
                     /gene_synonym="C15orf20; PIF"
                     /coded_by="XM_011522084.3:197..2122"
                     /db_xref="GeneID:80119"
                     /db_xref="HGNC:HGNC:26220"
                     /db_xref="MIM:610953"
ORIGIN      
        1 mlsgieaaag eyedselrcr vaveelspgg qprrrqalrt aelslgrner relmlrlqap
       61 gpagrprcfp lraarlftrf aeagrstlrl pahdtpgaga vqlllsdcpp drlrrflrtl
      121 rlklaaapgp gpasaraqll gprprdfvti spvqpeerrl raatrvpdtt lvkrpvepqa
      181 gaepsteapr wplpvkrlsl pstkpqlsee qaavlravlk gqsifftgsa gtgksyllkr
      241 ilgslpptgt vatastgvaa chiggttlha fagigsgqap laqcvalaqr pgvrqgwlnc
      301 qrlvideism veadlfdkle avaravrqqn kpfggiqlii cgdflqlppv tkgsqpprfc
      361 fqskswkrcv pvtleltkvw rqadqtfisl lqavrlgrcs devtrqlqat ashkvgrdgi
      421 vatrlcthqd dvaltnerrl qelpgkvhrf eamdsnpela stldaqcpvs qllqlklgaq
      481 vmlvknlsvs rglvngargv vvgfeaegrg lpqvrflcgv tevihadrwt vqatggqlls
      541 rqqlplqlaw amsihksqgm tldcveislg rvfasgqayv alsrarslqg lrvldfdpma
      601 vrcdprvlhf yatlrrgrsl slespdddea asdqenmdpi l
//
LOCUS       XP_011520385             641 aa            linear   PRI 05-AUG-2025
DEFINITION  ATP-dependent DNA helicase PIF1 isoform X1 [Homo sapiens].
ACCESSION   XP_011520385
VERSION     XP_011520385.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522083.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..641
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..641
                     /product="ATP-dependent DNA helicase PIF1 isoform X1"
                     /calculated_mol_wt=69668
     Region          <27..209
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          207..504
                     /region_name="PIF1"
                     /note="PIF1-like helicase; pfam05970"
                     /db_xref="CDD:428699"
     Site            order(211,229..236,306,346)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:350795"
     Region          <487..>640
                     /region_name="PRK13889"
                     /note="conjugal transfer relaxase TraA; Provisional"
                     /db_xref="CDD:237546"
     Region          <548..593
                     /region_name="SF1_C_RecD"
                     /note="C-terminal helicase domain of RecD family
                     helicases; cd18809"
                     /db_xref="CDD:350196"
     Site            559
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:350196"
     CDS             1..641
                     /gene="PIF1"
                     /gene_synonym="C15orf20; PIF"
                     /coded_by="XM_011522083.3:101..2026"
                     /db_xref="GeneID:80119"
                     /db_xref="HGNC:HGNC:26220"
                     /db_xref="MIM:610953"
ORIGIN      
        1 mlsgieaaag eyedselrcr vaveelspgg qprrrqalrt aelslgrner relmlrlqap
       61 gpagrprcfp lraarlftrf aeagrstlrl pahdtpgaga vqlllsdcpp drlrrflrtl
      121 rlklaaapgp gpasaraqll gprprdfvti spvqpeerrl raatrvpdtt lvkrpvepqa
      181 gaepsteapr wplpvkrlsl pstkpqlsee qaavlravlk gqsifftgsa gtgksyllkr
      241 ilgslpptgt vatastgvaa chiggttlha fagigsgqap laqcvalaqr pgvrqgwlnc
      301 qrlvideism veadlfdkle avaravrqqn kpfggiqlii cgdflqlppv tkgsqpprfc
      361 fqskswkrcv pvtleltkvw rqadqtfisl lqavrlgrcs devtrqlqat ashkvgrdgi
      421 vatrlcthqd dvaltnerrl qelpgkvhrf eamdsnpela stldaqcpvs qllqlklgaq
      481 vmlvknlsvs rglvngargv vvgfeaegrg lpqvrflcgv tevihadrwt vqatggqlls
      541 rqqlplqlaw amsihksqgm tldcveislg rvfasgqayv alsrarslqg lrvldfdpma
      601 vrcdprvlhf yatlrrgrsl slespdddea asdqenmdpi l
//
LOCUS       XP_047289096             402 aa            linear   PRI 05-AUG-2025
DEFINITION  ATP-dependent DNA helicase PIF1 isoform X2 [Homo sapiens].
ACCESSION   XP_047289096
VERSION     XP_047289096.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433140.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..402
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..402
                     /product="ATP-dependent DNA helicase PIF1 isoform X2"
                     /calculated_mol_wt=43525
     Region          210..381
                     /region_name="DEXSc_Pif1_like"
                     /note="DEAD-box helicase domain of Pif1; cd18037"
                     /db_xref="CDD:350795"
     Site            order(211,229..236,306,346)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:350795"
     CDS             1..402
                     /gene="PIF1"
                     /gene_synonym="C15orf20; PIF"
                     /coded_by="XM_047433140.1:75..1283"
                     /db_xref="GeneID:80119"
                     /db_xref="HGNC:HGNC:26220"
                     /db_xref="MIM:610953"
ORIGIN      
        1 mlsgieaaag eyedselrcr vaveelspgg qprrrqalrt aelslgrner relmlrlqap
       61 gpagrprcfp lraarlftrf aeagrstlrl pahdtpgaga vqlllsdcpp drlrrflrtl
      121 rlklaaapgp gpasaraqll gprprdfvti spvqpeerrl raatrvpdtt lvkrpvepqa
      181 gaepsteapr wplpvkrlsl pstkpqlsee qaavlravlk gqsifftgsa gtgksyllkr
      241 ilgslpptgt vatastgvaa chiggttlha fagigsgqap laqcvalaqr pgvrqgwlnc
      301 qrlvideism veadlfdkle avaravrqqn kpfggiqlii cgdflqlppv tkgsqpprfc
      361 fqskswkrcv pvtleltkvw rqadqtfisl lqavrlgrwa lp
//
LOCUS       XP_011520387            1038 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 33 isoform X1 [Homo sapiens].
ACCESSION   XP_011520387
VERSION     XP_011520387.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522085.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1038
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1038
                     /product="coiled-coil domain-containing protein 33 isoform
                     X1"
                     /calculated_mol_wt=115611
     Region          255..350
                     /region_name="C2"
                     /note="C2 domain; cd00030"
                     /db_xref="CDD:175973"
     Region          <654..>791
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     CDS             1..1038
                     /gene="CCDC33"
                     /gene_synonym="CC2D3; CT61; HP11097"
                     /coded_by="XM_011522085.4:72..3188"
                     /db_xref="GeneID:80125"
                     /db_xref="HGNC:HGNC:26552"
                     /db_xref="MIM:618525"
ORIGIN      
        1 mafrgpepwv sasllrqrlk aeektldlef evlsvgfnea gryalrlsae nplqvgsgag
       61 vqlqvndgdp fpacsaitdv ieqqepgqsl tltrskfift lpkgfckndg qhdaqlhvea
      121 lrldeplgra aqrvgeaifp iyprpdqprm npkaqdhedl yrycgnlall rastdptarh
      181 cgslaysvaf hvhrgpqppv sdsppragqp elmspcpepq lpilqntedp eepliasqst
      241 epeighlsps kketimvtlh gatnlpackd gsepwpyvvv kstseeknnq sskavtsvts
      301 eptrapiwgd tvnveiqaed agqedvilkv vdnrkkqell sykipikylr vfhpyhfelv
      361 kptesgkade ataktqlyat vvrkssfipr yigcnhmale iflrgvnepl annpnpivvi
      421 arvvpnykef kvsqanrdla svglpitpls fpipsmmnfd vprvsqngcp qlskpggppe
      481 qplwnqsflf qgrdgatsfs edtalvleyy sstsmkgsqp wtlnqplgis vlplksrlyq
      541 kmltgkgldg lhverlpimd tslktindea ptvalsfqll sserpenflt pnnskalptl
      601 dpkildkklr tiqeswskdt vsstmdlsts tpreaeeepl vpemshdtem nnyrramqkm
      661 aedilslrrq asilegenri lrsrlaqqee eegqgkasea qntvsmkqkl llseldmkkl
      721 rdrvqhlqne lirkndreke llllyqaqqp qaallkqyqg klqkmkalee tvrhqekvie
      781 kmervledrl qdrskpppln rqqgkpytgf pmlsasglpl gsmgenlpve lysvllaena
      841 klrteldknr hqqapiilqq qalpvdpgel gaggdlterl qethgpghse ctetlpaqdl
      901 lsgtsdkfnl laklehaqsr ilslesqled sarrwgrekq dlatrlqeqe kgfrhpsnsi
      961 iieqppyslp papgasifgk pratvdpggw reeafqsrgq gdgplpdpek kqghqrpall
     1021 gntreacpfh lpqniyhv
//
LOCUS       XP_016878112            1007 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 33 isoform X2 [Homo sapiens].
ACCESSION   XP_016878112
VERSION     XP_016878112.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022623.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1007
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1007
                     /product="coiled-coil domain-containing protein 33 isoform
                     X2"
                     /calculated_mol_wt=112246
     Region          255..350
                     /region_name="C2"
                     /note="C2 domain; cd00030"
                     /db_xref="CDD:175973"
     Region          <654..>791
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     CDS             1..1007
                     /gene="CCDC33"
                     /gene_synonym="CC2D3; CT61; HP11097"
                     /coded_by="XM_017022623.2:72..3095"
                     /db_xref="GeneID:80125"
                     /db_xref="HGNC:HGNC:26552"
                     /db_xref="MIM:618525"
ORIGIN      
        1 mafrgpepwv sasllrqrlk aeektldlef evlsvgfnea gryalrlsae nplqvgsgag
       61 vqlqvndgdp fpacsaitdv ieqqepgqsl tltrskfift lpkgfckndg qhdaqlhvea
      121 lrldeplgra aqrvgeaifp iyprpdqprm npkaqdhedl yrycgnlall rastdptarh
      181 cgslaysvaf hvhrgpqppv sdsppragqp elmspcpepq lpilqntedp eepliasqst
      241 epeighlsps kketimvtlh gatnlpackd gsepwpyvvv kstseeknnq sskavtsvts
      301 eptrapiwgd tvnveiqaed agqedvilkv vdnrkkqell sykipikylr vfhpyhfelv
      361 kptesgkade ataktqlyat vvrkssfipr yigcnhmale iflrgvnepl annpnpivvi
      421 arvvpnykef kvsqanrdla svglpitpls fpipsmmnfd vprvsqngcp qlskpggppe
      481 qplwnqsflf qgrdgatsfs edtalvleyy sstsmkgsqp wtlnqplgis vlplksrlyq
      541 kmltgkgldg lhverlpimd tslktindea ptvalsfqll sserpenflt pnnskalptl
      601 dpkildkklr tiqeswskdt vsstmdlsts tpreaeeepl vpemshdtem nnyrramqkm
      661 aedilslrrq asilegenri lrsrlaqqee eegqgkasea qntvsmkqkl llseldmkkl
      721 rdrvqhlqne lirkndreke llllyqaqqp qaallkqyqg klqkmkalee tvrhqekvie
      781 kmervledrl qdrskpppln rqqgkpytgf pmlsasglpl gsmgenlpve lysvllaena
      841 klrteldknr hqqapiilqq qalpvdpgel gaggdlterl qethgpghse ctetlpaqdl
      901 lsgtsdkfnl laklehaqsr ilslesqled sarrwgrekq dlatrlqeqe kgfrhpsnsi
      961 iieqpsalth smdlkqpsel epllpssdsk lnkplspqke tansqqt
//
LOCUS       XP_016878113            1004 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 33 isoform X3 [Homo sapiens].
ACCESSION   XP_016878113
VERSION     XP_016878113.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022624.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1004
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1004
                     /product="coiled-coil domain-containing protein 33 isoform
                     X3"
                     /calculated_mol_wt=112126
     Region          255..350
                     /region_name="C2"
                     /note="C2 domain; cd00030"
                     /db_xref="CDD:175973"
     Region          645..>895
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1004
                     /gene="CCDC33"
                     /gene_synonym="CC2D3; CT61; HP11097"
                     /coded_by="XM_017022624.2:72..3086"
                     /db_xref="GeneID:80125"
                     /db_xref="HGNC:HGNC:26552"
                     /db_xref="MIM:618525"
ORIGIN      
        1 mafrgpepwv sasllrqrlk aeektldlef evlsvgfnea gryalrlsae nplqvgsgag
       61 vqlqvndgdp fpacsaitdv ieqqepgqsl tltrskfift lpkgfckndg qhdaqlhvea
      121 lrldeplgra aqrvgeaifp iyprpdqprm npkaqdhedl yrycgnlall rastdptarh
      181 cgslaysvaf hvhrgpqppv sdsppragqp elmspcpepq lpilqntedp eepliasqst
      241 epeighlsps kketimvtlh gatnlpackd gsepwpyvvv kstseeknnq sskavtsvts
      301 eptrapiwgd tvnveiqaed agqedvilkv vdnrkkqell sykipikylr vfhpyhfelv
      361 kptesgkade ataktqlyat vvrkssfipr yigcnhmale iflrgvnepl annpnpivvi
      421 arvvpnykef kvsqanrdla svglpitpls fpipsmmnfd vprvsqngcp qlskpggppe
      481 qplwnqsflf qgrdgatsfs edtalvleyy sstsmkgsqp wtlnqplgis vlplksrlyq
      541 kmltgkgldg lhverlpimd tslktindea ptvalsfqll sserpenflt pnnskalptl
      601 dpkildkklr tiqeswskdt vsstmdlsts tpreaeeepl vpemshdtem nnyrramqkm
      661 aedilslrrq asilegenri lrsrlaqqee eegqgkasea qntvsmkqkl llseldmkkl
      721 rdrvqhlqne lirkndreke llllyqaqqp qaallkqyqg klqkmkalee tvrhqekvie
      781 kmervledrl qdrskpppln rqqgkpytgf pmlsasglpl gsmgenlpve lysvllaena
      841 klrteldknr hqqapiilqq qalpdllsgt sdkfnllakl ehaqsrilsl esqledsarr
      901 wgrekqdlat rlqeqekgfr hpsnsiiieq ppyslppapg asifgkprat vdpggwreea
      961 fqsrgqgdgp lpdpekkqgh qrpallgntr eacpfhlpqn iyhv
//
LOCUS       XP_016878114             992 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 33 isoform X4 [Homo sapiens].
ACCESSION   XP_016878114
VERSION     XP_016878114.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022625.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..992
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..992
                     /product="coiled-coil domain-containing protein 33 isoform
                     X4"
                     /calculated_mol_wt=110167
     Region          255..350
                     /region_name="C2"
                     /note="C2 domain; cd00030"
                     /db_xref="CDD:175973"
     Region          <654..>791
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     CDS             1..992
                     /gene="CCDC33"
                     /gene_synonym="CC2D3; CT61; HP11097"
                     /coded_by="XM_017022625.2:72..3050"
                     /db_xref="GeneID:80125"
                     /db_xref="HGNC:HGNC:26552"
                     /db_xref="MIM:618525"
ORIGIN      
        1 mafrgpepwv sasllrqrlk aeektldlef evlsvgfnea gryalrlsae nplqvgsgag
       61 vqlqvndgdp fpacsaitdv ieqqepgqsl tltrskfift lpkgfckndg qhdaqlhvea
      121 lrldeplgra aqrvgeaifp iyprpdqprm npkaqdhedl yrycgnlall rastdptarh
      181 cgslaysvaf hvhrgpqppv sdsppragqp elmspcpepq lpilqntedp eepliasqst
      241 epeighlsps kketimvtlh gatnlpackd gsepwpyvvv kstseeknnq sskavtsvts
      301 eptrapiwgd tvnveiqaed agqedvilkv vdnrkkqell sykipikylr vfhpyhfelv
      361 kptesgkade ataktqlyat vvrkssfipr yigcnhmale iflrgvnepl annpnpivvi
      421 arvvpnykef kvsqanrdla svglpitpls fpipsmmnfd vprvsqngcp qlskpggppe
      481 qplwnqsflf qgrdgatsfs edtalvleyy sstsmkgsqp wtlnqplgis vlplksrlyq
      541 kmltgkgldg lhverlpimd tslktindea ptvalsfqll sserpenflt pnnskalptl
      601 dpkildkklr tiqeswskdt vsstmdlsts tpreaeeepl vpemshdtem nnyrramqkm
      661 aedilslrrq asilegenri lrsrlaqqee eegqgkasea qntvsmkqkl llseldmkkl
      721 rdrvqhlqne lirkndreke llllyqaqqp qaallkqyqg klqkmkalee tvrhqekvie
      781 kmervledrl qdrskpppln rqqgkpytgf pmlsasglpl gsmgenlpve lysvllaena
      841 klrteldknr hqqapiilqq qalpvdpgel gaggdlterl qethgpghse ctetlpaqdl
      901 lsgtsdkfnl laklehaqsr ilslesqled sarrwgrekq dlatrlqeqe kgfrhpsnsi
      961 iieqpvsdpp gvaprgsggg agshrtpkvt gp
//
LOCUS       XP_016878115             973 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 33 isoform X5 [Homo sapiens].
ACCESSION   XP_016878115
VERSION     XP_016878115.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022626.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..973
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..973
                     /product="coiled-coil domain-containing protein 33 isoform
                     X5"
                     /calculated_mol_wt=108761
     Region          255..350
                     /region_name="C2"
                     /note="C2 domain; cd00030"
                     /db_xref="CDD:175973"
     Region          645..>895
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..973
                     /gene="CCDC33"
                     /gene_synonym="CC2D3; CT61; HP11097"
                     /coded_by="XM_017022626.3:72..2993"
                     /db_xref="GeneID:80125"
                     /db_xref="HGNC:HGNC:26552"
                     /db_xref="MIM:618525"
ORIGIN      
        1 mafrgpepwv sasllrqrlk aeektldlef evlsvgfnea gryalrlsae nplqvgsgag
       61 vqlqvndgdp fpacsaitdv ieqqepgqsl tltrskfift lpkgfckndg qhdaqlhvea
      121 lrldeplgra aqrvgeaifp iyprpdqprm npkaqdhedl yrycgnlall rastdptarh
      181 cgslaysvaf hvhrgpqppv sdsppragqp elmspcpepq lpilqntedp eepliasqst
      241 epeighlsps kketimvtlh gatnlpackd gsepwpyvvv kstseeknnq sskavtsvts
      301 eptrapiwgd tvnveiqaed agqedvilkv vdnrkkqell sykipikylr vfhpyhfelv
      361 kptesgkade ataktqlyat vvrkssfipr yigcnhmale iflrgvnepl annpnpivvi
      421 arvvpnykef kvsqanrdla svglpitpls fpipsmmnfd vprvsqngcp qlskpggppe
      481 qplwnqsflf qgrdgatsfs edtalvleyy sstsmkgsqp wtlnqplgis vlplksrlyq
      541 kmltgkgldg lhverlpimd tslktindea ptvalsfqll sserpenflt pnnskalptl
      601 dpkildkklr tiqeswskdt vsstmdlsts tpreaeeepl vpemshdtem nnyrramqkm
      661 aedilslrrq asilegenri lrsrlaqqee eegqgkasea qntvsmkqkl llseldmkkl
      721 rdrvqhlqne lirkndreke llllyqaqqp qaallkqyqg klqkmkalee tvrhqekvie
      781 kmervledrl qdrskpppln rqqgkpytgf pmlsasglpl gsmgenlpve lysvllaena
      841 klrteldknr hqqapiilqq qalpdllsgt sdkfnllakl ehaqsrilsl esqledsarr
      901 wgrekqdlat rlqeqekgfr hpsnsiiieq psalthsmdl kqpselepll pssdsklnkp
      961 lspqketans qqt
//
LOCUS       XP_016878116             969 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 33 isoform X6 [Homo sapiens].
ACCESSION   XP_016878116
VERSION     XP_016878116.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022627.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..969
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..969
                     /product="coiled-coil domain-containing protein 33 isoform
                     X6"
                     /calculated_mol_wt=108121
     Region          255..350
                     /region_name="C2"
                     /note="C2 domain; cd00030"
                     /db_xref="CDD:175973"
     Region          <654..>791
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     CDS             1..969
                     /gene="CCDC33"
                     /gene_synonym="CC2D3; CT61; HP11097"
                     /coded_by="XM_017022627.2:72..2981"
                     /db_xref="GeneID:80125"
                     /db_xref="HGNC:HGNC:26552"
                     /db_xref="MIM:618525"
ORIGIN      
        1 mafrgpepwv sasllrqrlk aeektldlef evlsvgfnea gryalrlsae nplqvgsgag
       61 vqlqvndgdp fpacsaitdv ieqqepgqsl tltrskfift lpkgfckndg qhdaqlhvea
      121 lrldeplgra aqrvgeaifp iyprpdqprm npkaqdhedl yrycgnlall rastdptarh
      181 cgslaysvaf hvhrgpqppv sdsppragqp elmspcpepq lpilqntedp eepliasqst
      241 epeighlsps kketimvtlh gatnlpackd gsepwpyvvv kstseeknnq sskavtsvts
      301 eptrapiwgd tvnveiqaed agqedvilkv vdnrkkqell sykipikylr vfhpyhfelv
      361 kptesgkade ataktqlyat vvrkssfipr yigcnhmale iflrgvnepl annpnpivvi
      421 arvvpnykef kvsqanrdla svglpitpls fpipsmmnfd vprvsqngcp qlskpggppe
      481 qplwnqsflf qgrdgatsfs edtalvleyy sstsmkgsqp wtlnqplgis vlplksrlyq
      541 kmltgkgldg lhverlpimd tslktindea ptvalsfqll sserpenflt pnnskalptl
      601 dpkildkklr tiqeswskdt vsstmdlsts tpreaeeepl vpemshdtem nnyrramqkm
      661 aedilslrrq asilegenri lrsrlaqqee eegqgkasea qntvsmkqkl llseldmkkl
      721 rdrvqhlqne lirkndreke llllyqaqqp qaallkqyqg klqkmkalee tvrhqekvie
      781 kmervledrl qdrskpppln rqqgkpytgf pmlsasglpl gsmgenlpve lysvllaena
      841 klrteldknr hqqapiilqq qalpvdpgel gaggdlterl qethgpghse ctetlpaqdl
      901 lsgtsdkfnl laklehaqsr ilslesqled sarrwgrekq dlatrlqeqe kgfrhpsnsi
      961 iieqpmatm
//
LOCUS       XP_016878117             958 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 33 isoform X7 [Homo sapiens].
ACCESSION   XP_016878117
VERSION     XP_016878117.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022628.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..958
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..958
                     /product="coiled-coil domain-containing protein 33 isoform
                     X7"
                     /calculated_mol_wt=106683
     Region          255..350
                     /region_name="C2"
                     /note="C2 domain; cd00030"
                     /db_xref="CDD:175973"
     Region          645..>895
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..958
                     /gene="CCDC33"
                     /gene_synonym="CC2D3; CT61; HP11097"
                     /coded_by="XM_017022628.2:72..2948"
                     /db_xref="GeneID:80125"
                     /db_xref="HGNC:HGNC:26552"
                     /db_xref="MIM:618525"
ORIGIN      
        1 mafrgpepwv sasllrqrlk aeektldlef evlsvgfnea gryalrlsae nplqvgsgag
       61 vqlqvndgdp fpacsaitdv ieqqepgqsl tltrskfift lpkgfckndg qhdaqlhvea
      121 lrldeplgra aqrvgeaifp iyprpdqprm npkaqdhedl yrycgnlall rastdptarh
      181 cgslaysvaf hvhrgpqppv sdsppragqp elmspcpepq lpilqntedp eepliasqst
      241 epeighlsps kketimvtlh gatnlpackd gsepwpyvvv kstseeknnq sskavtsvts
      301 eptrapiwgd tvnveiqaed agqedvilkv vdnrkkqell sykipikylr vfhpyhfelv
      361 kptesgkade ataktqlyat vvrkssfipr yigcnhmale iflrgvnepl annpnpivvi
      421 arvvpnykef kvsqanrdla svglpitpls fpipsmmnfd vprvsqngcp qlskpggppe
      481 qplwnqsflf qgrdgatsfs edtalvleyy sstsmkgsqp wtlnqplgis vlplksrlyq
      541 kmltgkgldg lhverlpimd tslktindea ptvalsfqll sserpenflt pnnskalptl
      601 dpkildkklr tiqeswskdt vsstmdlsts tpreaeeepl vpemshdtem nnyrramqkm
      661 aedilslrrq asilegenri lrsrlaqqee eegqgkasea qntvsmkqkl llseldmkkl
      721 rdrvqhlqne lirkndreke llllyqaqqp qaallkqyqg klqkmkalee tvrhqekvie
      781 kmervledrl qdrskpppln rqqgkpytgf pmlsasglpl gsmgenlpve lysvllaena
      841 klrteldknr hqqapiilqq qalpdllsgt sdkfnllakl ehaqsrilsl esqledsarr
      901 wgrekqdlat rlqeqekgfr hpsnsiiieq pvsdppgvap rgsgggagsh rtpkvtgp
//
LOCUS       XP_047289097             889 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 33 isoform X8 [Homo sapiens].
ACCESSION   XP_047289097
VERSION     XP_047289097.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433141.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..889
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..889
                     /product="coiled-coil domain-containing protein 33 isoform
                     X8"
                     /calculated_mol_wt=99185
     Region          106..201
                     /region_name="C2"
                     /note="C2 domain; cd00030"
                     /db_xref="CDD:175973"
     Region          <505..>642
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     CDS             1..889
                     /gene="CCDC33"
                     /gene_synonym="CC2D3; CT61; HP11097"
                     /coded_by="XM_047433141.1:517..3186"
                     /db_xref="GeneID:80125"
                     /db_xref="HGNC:HGNC:26552"
                     /db_xref="MIM:618525"
ORIGIN      
        1 mnpkaqdhed lyrycgnlal lrastdptar hcgslaysva fhvhrgpqpp vsdsppragq
       61 pelmspcpep qlpilqnted peepliasqs tepeighlsp skketimvtl hgatnlpack
      121 dgsepwpyvv vkstseeknn qsskavtsvt septrapiwg dtvnveiqae dagqedvilk
      181 vvdnrkkqel lsykipikyl rvfhpyhfel vkptesgkad eataktqlya tvvrkssfip
      241 ryigcnhmal eiflrgvnep lannpnpivv iarvvpnyke fkvsqanrdl asvglpitpl
      301 sfpipsmmnf dvprvsqngc pqlskpggpp eqplwnqsfl fqgrdgatsf sedtalvley
      361 ysstsmkgsq pwtlnqplgi svlplksrly qkmltgkgld glhverlpim dtslktinde
      421 aptvalsfql lsserpenfl tpnnskalpt ldpkildkkl rtiqeswskd tvsstmdlst
      481 stpreaeeep lvpemshdte mnnyrramqk maedilslrr qasilegenr ilrsrlaqqe
      541 eeegqgkase aqntvsmkqk lllseldmkk lrdrvqhlqn elirkndrek ellllyqaqq
      601 pqaallkqyq gklqkmkale etvrhqekvi ekmervledr lqdrskpppl nrqqgkpytg
      661 fpmlsasglp lgsmgenlpv elysvllaen aklrteldkn rhqqapiilq qqalpvdpge
      721 lgaggdlter lqethgpghs ectetlpaqd llsgtsdkfn llaklehaqs rilslesqle
      781 dsarrwgrek qdlatrlqeq ekgfrhpsns iiieqppysl ppapgasifg kpratvdpgg
      841 wreeafqsrg qgdgplpdpe kkqghqrpal lgntreacpf hlpqniyhv
//
LOCUS       XP_047289098             862 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 33 isoform X9 [Homo sapiens].
ACCESSION   XP_047289098
VERSION     XP_047289098.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433142.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..862
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..862
                     /product="coiled-coil domain-containing protein 33 isoform
                     X9"
                     /calculated_mol_wt=96443
     Region          255..350
                     /region_name="C2"
                     /note="C2 domain; cd00030"
                     /db_xref="CDD:175973"
     Region          <606..>783
                     /region_name="sbcc"
                     /note="exonuclease SbcC; TIGR00618"
                     /db_xref="CDD:129705"
     CDS             1..862
                     /gene="CCDC33"
                     /gene_synonym="CC2D3; CT61; HP11097"
                     /coded_by="XM_047433142.1:72..2660"
                     /db_xref="GeneID:80125"
                     /db_xref="HGNC:HGNC:26552"
                     /db_xref="MIM:618525"
ORIGIN      
        1 mafrgpepwv sasllrqrlk aeektldlef evlsvgfnea gryalrlsae nplqvgsgag
       61 vqlqvndgdp fpacsaitdv ieqqepgqsl tltrskfift lpkgfckndg qhdaqlhvea
      121 lrldeplgra aqrvgeaifp iyprpdqprm npkaqdhedl yrycgnlall rastdptarh
      181 cgslaysvaf hvhrgpqppv sdsppragqp elmspcpepq lpilqntedp eepliasqst
      241 epeighlsps kketimvtlh gatnlpackd gsepwpyvvv kstseeknnq sskavtsvts
      301 eptrapiwgd tvnveiqaed agqedvilkv vdnrkkqell sykipikylr vfhpyhfelv
      361 kptesgkade ataktqlyat vvrkssfipr yigcnhmale iflrgvnepl annpnpivvi
      421 arvvpnykef kvsqanrdla svglpitpls fpipsmmnfd vprvsqngcp qlskpggppe
      481 qplwnqsflf qgrdgatsfs edtalvleyy sstsmkgsqp wtlnqplgis vlplksrlyq
      541 kmltgkgldg lhverlpimd tslktindea ptvalsfqll sserpenflt pnnskalptl
      601 dpkildkklr tiqeswskdt vsstmdlsts tpreaeeepl vpemshdtem nnyrramqkm
      661 aedilslrrq asilegenri lrsrlaqqee eegqgkasea qntvsmkqkl llseldmkkl
      721 rdrvqhlqne lirkndreke llllyqaqqp qaallkqyqg klqkmkalee tvrhqekasl
      781 csqplafpwv lwertcrlnf trccwqktrs cgrswirtat srppsfcsnr pcrisslvlq
      841 tsstswpswn tlragscpwk as
//
LOCUS       XP_011520388             826 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 33 isoform X10 [Homo
            sapiens].
ACCESSION   XP_011520388
VERSION     XP_011520388.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522086.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..826
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..826
                     /product="coiled-coil domain-containing protein 33 isoform
                     X10"
                     /calculated_mol_wt=92479
     Region          43..138
                     /region_name="C2"
                     /note="C2 domain; cd00030"
                     /db_xref="CDD:175973"
     Region          <442..>579
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     CDS             1..826
                     /gene="CCDC33"
                     /gene_synonym="CC2D3; CT61; HP11097"
                     /coded_by="XM_011522086.1:107..2587"
                     /db_xref="GeneID:80125"
                     /db_xref="HGNC:HGNC:26552"
                     /db_xref="MIM:618525"
ORIGIN      
        1 maqvnswhet whtntedpee pliasqstep eighlspskk etimvtlhga tnlpackdgs
       61 epwpyvvvks tseeknnqss kavtsvtsep trapiwgdtv nveiqaedag qedvilkvvd
      121 nrkkqellsy kipikylrvf hpyhfelvkp tesgkadeat aktqlyatvv rkssfipryi
      181 gcnhmaleif lrgvneplan npnpivviar vvpnykefkv sqanrdlasv glpitplsfp
      241 ipsmmnfdvp rvsqngcpql skpggppeqp lwnqsflfqg rdgatsfsed talvleyyss
      301 tsmkgsqpwt lnqplgisvl plksrlyqkm ltgkgldglh verlpimdts lktindeapt
      361 valsfqllss erpenfltpn nskalptldp kildkklrti qeswskdtvs stmdlststp
      421 reaeeeplvp emshdtemnn yrramqkmae dilslrrqas ilegenrilr srlaqqeeee
      481 gqgkaseaqn tvsmkqklll seldmkklrd rvqhlqneli rkndrekell llyqaqqpqa
      541 allkqyqgkl qkmkaleetv rhqekviekm ervledrlqd rskppplnrq qgkpytgfpm
      601 lsasglplgs mgenlpvely svllaenakl rteldknrhq qapiilqqqa lpvdpgelga
      661 ggdlterlqe thgpghsect etlpaqdlls gtsdkfnlla klehaqsril slesqledsa
      721 rrwgrekqdl atrlqeqekg frhpsnsiii eqppyslppa pgasifgkpr atvdpggwre
      781 eafqsrgqgd gplpdpekkq ghqrpallgn treacpfhlp qniyhv
//
LOCUS       XP_005254749             820 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 33 isoform X11 [Homo
            sapiens].
ACCESSION   XP_005254749
VERSION     XP_005254749.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254692.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..820
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..820
                     /product="coiled-coil domain-containing protein 33 isoform
                     X11"
                     /calculated_mol_wt=91671
     Region          37..132
                     /region_name="C2"
                     /note="C2 domain; cd00030"
                     /db_xref="CDD:175973"
     Region          <436..>573
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     CDS             1..820
                     /gene="CCDC33"
                     /gene_synonym="CC2D3; CT61; HP11097"
                     /coded_by="XM_005254692.2:395..2857"
                     /db_xref="GeneID:80125"
                     /db_xref="HGNC:HGNC:26552"
                     /db_xref="MIM:618525"
ORIGIN      
        1 mglknkknte dpeepliasq stepeighls pskketimvt lhgatnlpac kdgsepwpyv
       61 vvkstseekn nqsskavtsv tseptrapiw gdtvnveiqa edagqedvil kvvdnrkkqe
      121 llsykipiky lrvfhpyhfe lvkptesgka deataktqly atvvrkssfi pryigcnhma
      181 leiflrgvne plannpnpiv viarvvpnyk efkvsqanrd lasvglpitp lsfpipsmmn
      241 fdvprvsqng cpqlskpggp peqplwnqsf lfqgrdgats fsedtalvle yysstsmkgs
      301 qpwtlnqplg isvlplksrl yqkmltgkgl dglhverlpi mdtslktind eaptvalsfq
      361 llsserpenf ltpnnskalp tldpkildkk lrtiqeswsk dtvsstmdls tstpreaeee
      421 plvpemshdt emnnyrramq kmaedilslr rqasilegen rilrsrlaqq eeeegqgkas
      481 eaqntvsmkq klllseldmk klrdrvqhlq nelirkndre kellllyqaq qpqaallkqy
      541 qgklqkmkal eetvrhqekv iekmervled rlqdrskppp lnrqqgkpyt gfpmlsasgl
      601 plgsmgenlp velysvllae naklrteldk nrhqqapiil qqqalpvdpg elgaggdlte
      661 rlqethgpgh sectetlpaq dllsgtsdkf nllaklehaq srilslesql edsarrwgre
      721 kqdlatrlqe qekgfrhpsn siiieqppys lppapgasif gkpratvdpg gwreeafqsr
      781 gqgdgplpdp ekkqghqrpa llgntreacp fhlpqniyhv
//
LOCUS       XP_011520389             820 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 33 isoform X11 [Homo
            sapiens].
ACCESSION   XP_011520389
VERSION     XP_011520389.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522087.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..820
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..820
                     /product="coiled-coil domain-containing protein 33 isoform
                     X11"
                     /calculated_mol_wt=91671
     Region          37..132
                     /region_name="C2"
                     /note="C2 domain; cd00030"
                     /db_xref="CDD:175973"
     Region          <436..>573
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     CDS             1..820
                     /gene="CCDC33"
                     /gene_synonym="CC2D3; CT61; HP11097"
                     /coded_by="XM_011522087.2:263..2725"
                     /db_xref="GeneID:80125"
                     /db_xref="HGNC:HGNC:26552"
                     /db_xref="MIM:618525"
ORIGIN      
        1 mglknkknte dpeepliasq stepeighls pskketimvt lhgatnlpac kdgsepwpyv
       61 vvkstseekn nqsskavtsv tseptrapiw gdtvnveiqa edagqedvil kvvdnrkkqe
      121 llsykipiky lrvfhpyhfe lvkptesgka deataktqly atvvrkssfi pryigcnhma
      181 leiflrgvne plannpnpiv viarvvpnyk efkvsqanrd lasvglpitp lsfpipsmmn
      241 fdvprvsqng cpqlskpggp peqplwnqsf lfqgrdgats fsedtalvle yysstsmkgs
      301 qpwtlnqplg isvlplksrl yqkmltgkgl dglhverlpi mdtslktind eaptvalsfq
      361 llsserpenf ltpnnskalp tldpkildkk lrtiqeswsk dtvsstmdls tstpreaeee
      421 plvpemshdt emnnyrramq kmaedilslr rqasilegen rilrsrlaqq eeeegqgkas
      481 eaqntvsmkq klllseldmk klrdrvqhlq nelirkndre kellllyqaq qpqaallkqy
      541 qgklqkmkal eetvrhqekv iekmervled rlqdrskppp lnrqqgkpyt gfpmlsasgl
      601 plgsmgenlp velysvllae naklrteldk nrhqqapiil qqqalpvdpg elgaggdlte
      661 rlqethgpgh sectetlpaq dllsgtsdkf nllaklehaq srilslesql edsarrwgre
      721 kqdlatrlqe qekgfrhpsn siiieqppys lppapgasif gkpratvdpg gwreeafqsr
      781 gqgdgplpdp ekkqghqrpa llgntreacp fhlpqniyhv
//
LOCUS       XP_016878119             707 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 33 isoform X12 [Homo
            sapiens].
ACCESSION   XP_016878119
VERSION     XP_016878119.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022630.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..707
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..707
                     /product="coiled-coil domain-containing protein 33 isoform
                     X12"
                     /calculated_mol_wt=78166
     Region          255..350
                     /region_name="C2"
                     /note="C2 domain; cd00030"
                     /db_xref="CDD:175973"
     CDS             1..707
                     /gene="CCDC33"
                     /gene_synonym="CC2D3; CT61; HP11097"
                     /coded_by="XM_017022630.2:72..2195"
                     /db_xref="GeneID:80125"
                     /db_xref="HGNC:HGNC:26552"
                     /db_xref="MIM:618525"
ORIGIN      
        1 mafrgpepwv sasllrqrlk aeektldlef evlsvgfnea gryalrlsae nplqvgsgag
       61 vqlqvndgdp fpacsaitdv ieqqepgqsl tltrskfift lpkgfckndg qhdaqlhvea
      121 lrldeplgra aqrvgeaifp iyprpdqprm npkaqdhedl yrycgnlall rastdptarh
      181 cgslaysvaf hvhrgpqppv sdsppragqp elmspcpepq lpilqntedp eepliasqst
      241 epeighlsps kketimvtlh gatnlpackd gsepwpyvvv kstseeknnq sskavtsvts
      301 eptrapiwgd tvnveiqaed agqedvilkv vdnrkkqell sykipikylr vfhpyhfelv
      361 kptesgkade ataktqlyat vvrkssfipr yigcnhmale iflrgvnepl annpnpivvi
      421 arvvpnykef kvsqanrdla svglpitpls fpipsmmnfd vprvsqngcp qlskpggppe
      481 qplwnqsflf qgrdgatsfs edtalvleyy sstsmkgsqp wtlnqplgis vlplksrlyq
      541 kmltgkgldg lhverlpimd tslktindea ptvalsfqll sserpenflt pnnskalptl
      601 dpkildkklr tiqeswskdt vsstmdlsts tpreaeeepl vpemshdtrv pwgtllwkil
      661 rkgprqghqs tgkskpsssq dltsstnsll ifpwhfctfl ehvpsde
//
LOCUS       XP_016878120             669 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 33 isoform X13 [Homo
            sapiens].
ACCESSION   XP_016878120
VERSION     XP_016878120.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022631.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..669
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..669
                     /product="coiled-coil domain-containing protein 33 isoform
                     X13"
                     /calculated_mol_wt=74144
     Region          255..350
                     /region_name="C2"
                     /note="C2 domain; cd00030"
                     /db_xref="CDD:175973"
     CDS             1..669
                     /gene="CCDC33"
                     /gene_synonym="CC2D3; CT61; HP11097"
                     /coded_by="XM_017022631.2:72..2081"
                     /db_xref="GeneID:80125"
                     /db_xref="HGNC:HGNC:26552"
                     /db_xref="MIM:618525"
ORIGIN      
        1 mafrgpepwv sasllrqrlk aeektldlef evlsvgfnea gryalrlsae nplqvgsgag
       61 vqlqvndgdp fpacsaitdv ieqqepgqsl tltrskfift lpkgfckndg qhdaqlhvea
      121 lrldeplgra aqrvgeaifp iyprpdqprm npkaqdhedl yrycgnlall rastdptarh
      181 cgslaysvaf hvhrgpqppv sdsppragqp elmspcpepq lpilqntedp eepliasqst
      241 epeighlsps kketimvtlh gatnlpackd gsepwpyvvv kstseeknnq sskavtsvts
      301 eptrapiwgd tvnveiqaed agqedvilkv vdnrkkqell sykipikylr vfhpyhfelv
      361 kptesgkade ataktqlyat vvrkssfipr yigcnhmale iflrgvnepl annpnpivvi
      421 arvvpnykef kvsqanrdla svglpitpls fpipsmmnfd vprvsqngcp qlskpggppe
      481 qplwnqsflf qgrdgatsfs edtalvleyy sstsmkgsqp wtlnqplgis vlplksrlyq
      541 kmltgkgldg lhverlpimd tslktindea ptvalsfqll sserpenflt pnnskalptl
      601 dpkildkklr tiqeswskdt vsstmdlsts tpreaeeepl vpemshdtir lqlnrklnif
      661 wrekrsgnr
//
LOCUS       XP_011520391             524 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 33 isoform X14 [Homo
            sapiens].
ACCESSION   XP_011520391
VERSION     XP_011520391.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522089.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..524
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..524
                     /product="coiled-coil domain-containing protein 33 isoform
                     X14"
                     /calculated_mol_wt=58960
     Region          <140..>277
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     CDS             1..524
                     /gene="CCDC33"
                     /gene_synonym="CC2D3; CT61; HP11097"
                     /coded_by="XM_011522089.4:304..1878"
                     /db_xref="GeneID:80125"
                     /db_xref="HGNC:HGNC:26552"
                     /db_xref="MIM:618525"
ORIGIN      
        1 mkgsqpwtln qplgisvlpl ksrlyqkmlt gkgldglhve rlpimdtslk tindeaptva
       61 lsfqllsser penfltpnns kalptldpki ldkklrtiqe swskdtvsst mdlststpre
      121 aeeeplvpem shdtemnnyr ramqkmaedi lslrrqasil egenrilrsr laqqeeeegq
      181 gkaseaqntv smkqklllse ldmkklrdrv qhlqnelirk ndrekellll yqaqqpqaal
      241 lkqyqgklqk mkaleetvrh qekviekmer vledrlqdrs kppplnrqqg kpytgfpmls
      301 asglplgsmg enlpvelysv llaenaklrt eldknrhqqa piilqqqalp vdpgelgagg
      361 dlterlqeth gpghsectet lpaqdllsgt sdkfnllakl ehaqsrilsl esqledsarr
      421 wgrekqdlat rlqeqekgfr hpsnsiiieq ppyslppapg asifgkprat vdpggwreea
      481 fqsrgqgdgp lpdpekkqgh qrpallgntr eacpfhlpqn iyhv
//
LOCUS       XP_024305845             508 aa            linear   PRI 05-AUG-2025
DEFINITION  enhancer of mRNA-decapping protein 3 isoform X1 [Homo sapiens].
ACCESSION   XP_024305845
VERSION     XP_024305845.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024450077.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..508
                     /product="enhancer of mRNA-decapping protein 3 isoform X1"
                     /calculated_mol_wt=55947
     Region          2..66
                     /region_name="LSm16_N"
                     /note="Like-Sm protein 16, N-terminal domain; cd01737"
                     /db_xref="CDD:212484"
     Site            order(2,5,28,33,56,59..64)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:212484"
     Site            order(10..15,19..30,33..36)
                     /site_type="other"
                     /note="Sm1 motif"
                     /db_xref="CDD:212484"
     Site            order(29,55)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:212484"
     Site            51..62
                     /site_type="other"
                     /note="Sm2 motif"
                     /db_xref="CDD:212484"
     Region          102..194
                     /region_name="Edc3_linker"
                     /note="Linker region of enhancer of mRNA-decapping protein
                     3; pfam16598"
                     /db_xref="CDD:465188"
     Region          198..301
                     /region_name="FDF"
                     /note="FDF domain; pfam09532"
                     /db_xref="CDD:430668"
     Region          302..455
                     /region_name="YjeF_N"
                     /note="YjeF-related protein N-terminus; pfam03853"
                     /db_xref="CDD:427546"
     CDS             1..508
                     /gene="EDC3"
                     /gene_synonym="hYjeF_N2-15q23; LSM16; MRT50; YJDC; YJEFN2"
                     /coded_by="XM_024450077.2:246..1772"
                     /db_xref="GeneID:80153"
                     /db_xref="HGNC:HGNC:26114"
                     /db_xref="MIM:609842"
ORIGIN      
        1 matdwlgsiv sincgdslgv yqgrvsavdq vsqtisltrp fhngvkclvp evtfragdit
       61 elkileipgp gdnqhfgdlh qtelgpsgag cqvginqngt gkfvkkpass ssapqnipkr
      121 tdvksqdvav spqqqqcsks yvdrhmesls qsksfrrrhn swssssrhpn qatpkksglk
      181 ngqmknkdde cfgddieeip dtdfdfegnl alfdkaavfe eidtyerrsg trsrgipner
      241 ptryrhdeni lesepivyrr iivphnvske fctdsglvvp sisyelhkkl lsvaekhglt
      301 lerrlemtgv casqmaltll ggpnrlnpkn vhqrptvall cgphvkgaqg iscgrhlanh
      361 dvqvilflpn fvkmlesitn elslfsktqg qqvsslkdlp tspvdlvinc ldcpenvflr
      421 dqpwykaava wanqnrapvl sidppvheve qgidakwsla lglplplgeh agriylcdig
      481 ipqqvfqevg inyhspfgck fviplhsa
//
LOCUS       XP_047289099             508 aa            linear   PRI 05-AUG-2025
DEFINITION  enhancer of mRNA-decapping protein 3 isoform X1 [Homo sapiens].
ACCESSION   XP_047289099
VERSION     XP_047289099.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433143.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..508
                     /product="enhancer of mRNA-decapping protein 3 isoform X1"
                     /calculated_mol_wt=55947
     Region          2..66
                     /region_name="LSm16_N"
                     /note="Like-Sm protein 16, N-terminal domain; cd01737"
                     /db_xref="CDD:212484"
     Site            order(2,5,28,33,56,59..64)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:212484"
     Site            order(10..15,19..30,33..36)
                     /site_type="other"
                     /note="Sm1 motif"
                     /db_xref="CDD:212484"
     Site            order(29,55)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:212484"
     Site            51..62
                     /site_type="other"
                     /note="Sm2 motif"
                     /db_xref="CDD:212484"
     Region          102..194
                     /region_name="Edc3_linker"
                     /note="Linker region of enhancer of mRNA-decapping protein
                     3; pfam16598"
                     /db_xref="CDD:465188"
     Region          198..301
                     /region_name="FDF"
                     /note="FDF domain; pfam09532"
                     /db_xref="CDD:430668"
     Region          302..455
                     /region_name="YjeF_N"
                     /note="YjeF-related protein N-terminus; pfam03853"
                     /db_xref="CDD:427546"
     CDS             1..508
                     /gene="EDC3"
                     /gene_synonym="hYjeF_N2-15q23; LSM16; MRT50; YJDC; YJEFN2"
                     /coded_by="XM_047433143.1:297..1823"
                     /db_xref="GeneID:80153"
                     /db_xref="HGNC:HGNC:26114"
                     /db_xref="MIM:609842"
ORIGIN      
        1 matdwlgsiv sincgdslgv yqgrvsavdq vsqtisltrp fhngvkclvp evtfragdit
       61 elkileipgp gdnqhfgdlh qtelgpsgag cqvginqngt gkfvkkpass ssapqnipkr
      121 tdvksqdvav spqqqqcsks yvdrhmesls qsksfrrrhn swssssrhpn qatpkksglk
      181 ngqmknkdde cfgddieeip dtdfdfegnl alfdkaavfe eidtyerrsg trsrgipner
      241 ptryrhdeni lesepivyrr iivphnvske fctdsglvvp sisyelhkkl lsvaekhglt
      301 lerrlemtgv casqmaltll ggpnrlnpkn vhqrptvall cgphvkgaqg iscgrhlanh
      361 dvqvilflpn fvkmlesitn elslfsktqg qqvsslkdlp tspvdlvinc ldcpenvflr
      421 dqpwykaava wanqnrapvl sidppvheve qgidakwsla lglplplgeh agriylcdig
      481 ipqqvfqevg inyhspfgck fviplhsa
//
LOCUS       XP_024305847             508 aa            linear   PRI 05-AUG-2025
DEFINITION  enhancer of mRNA-decapping protein 3 isoform X1 [Homo sapiens].
ACCESSION   XP_024305847
VERSION     XP_024305847.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024450079.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..508
                     /product="enhancer of mRNA-decapping protein 3 isoform X1"
                     /calculated_mol_wt=55947
     Region          2..66
                     /region_name="LSm16_N"
                     /note="Like-Sm protein 16, N-terminal domain; cd01737"
                     /db_xref="CDD:212484"
     Site            order(2,5,28,33,56,59..64)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:212484"
     Site            order(10..15,19..30,33..36)
                     /site_type="other"
                     /note="Sm1 motif"
                     /db_xref="CDD:212484"
     Site            order(29,55)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:212484"
     Site            51..62
                     /site_type="other"
                     /note="Sm2 motif"
                     /db_xref="CDD:212484"
     Region          102..194
                     /region_name="Edc3_linker"
                     /note="Linker region of enhancer of mRNA-decapping protein
                     3; pfam16598"
                     /db_xref="CDD:465188"
     Region          198..301
                     /region_name="FDF"
                     /note="FDF domain; pfam09532"
                     /db_xref="CDD:430668"
     Region          302..455
                     /region_name="YjeF_N"
                     /note="YjeF-related protein N-terminus; pfam03853"
                     /db_xref="CDD:427546"
     CDS             1..508
                     /gene="EDC3"
                     /gene_synonym="hYjeF_N2-15q23; LSM16; MRT50; YJDC; YJEFN2"
                     /coded_by="XM_024450079.2:469..1995"
                     /db_xref="GeneID:80153"
                     /db_xref="HGNC:HGNC:26114"
                     /db_xref="MIM:609842"
ORIGIN      
        1 matdwlgsiv sincgdslgv yqgrvsavdq vsqtisltrp fhngvkclvp evtfragdit
       61 elkileipgp gdnqhfgdlh qtelgpsgag cqvginqngt gkfvkkpass ssapqnipkr
      121 tdvksqdvav spqqqqcsks yvdrhmesls qsksfrrrhn swssssrhpn qatpkksglk
      181 ngqmknkdde cfgddieeip dtdfdfegnl alfdkaavfe eidtyerrsg trsrgipner
      241 ptryrhdeni lesepivyrr iivphnvske fctdsglvvp sisyelhkkl lsvaekhglt
      301 lerrlemtgv casqmaltll ggpnrlnpkn vhqrptvall cgphvkgaqg iscgrhlanh
      361 dvqvilflpn fvkmlesitn elslfsktqg qqvsslkdlp tspvdlvinc ldcpenvflr
      421 dqpwykaava wanqnrapvl sidppvheve qgidakwsla lglplplgeh agriylcdig
      481 ipqqvfqevg inyhspfgck fviplhsa
//
LOCUS       XP_011520394             325 aa            linear   PRI 05-AUG-2025
DEFINITION  enhancer of mRNA-decapping protein 3 isoform X2 [Homo sapiens].
ACCESSION   XP_011520394
VERSION     XP_011520394.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522092.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..325
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..325
                     /product="enhancer of mRNA-decapping protein 3 isoform X2"
                     /calculated_mol_wt=36193
     Region          15..118
                     /region_name="FDF"
                     /note="FDF domain; pfam09532"
                     /db_xref="CDD:430668"
     Region          119..272
                     /region_name="YjeF_N"
                     /note="YjeF-related protein N-terminus; pfam03853"
                     /db_xref="CDD:427546"
     CDS             1..325
                     /gene="EDC3"
                     /gene_synonym="hYjeF_N2-15q23; LSM16; MRT50; YJDC; YJEFN2"
                     /coded_by="XM_011522092.4:392..1369"
                     /db_xref="GeneID:80153"
                     /db_xref="HGNC:HGNC:26114"
                     /db_xref="MIM:609842"
ORIGIN      
        1 mknkddecfg ddieeipdtd fdfegnlalf dkaavfeeid tyerrsgtrs rgipnerptr
       61 yrhdeniles epivyrriiv phnvskefct dsglvvpsis yelhkkllsv aekhgltler
      121 rlemtgvcas qmaltllggp nrlnpknvhq rptvallcgp hvkgaqgisc grhlanhdvq
      181 vilflpnfvk mlesitnels lfsktqgqqv sslkdlptsp vdlvincldc penvflrdqp
      241 wykaavawan qnrapvlsid ppvheveqgi dakwslalgl plplgehagr iylcdigipq
      301 qvfqevginy hspfgckfvi plhsa
//
LOCUS       XP_047289100            2242 aa            linear   PRI 05-AUG-2025
DEFINITION  spatacsin isoform X1 [Homo sapiens].
ACCESSION   XP_047289100
VERSION     XP_047289100.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433144.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2242
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2242
                     /product="spatacsin isoform X1"
                     /calculated_mol_wt=257083
     Region          1894..2186
                     /region_name="Spatacsin_C"
                     /note="Spatacsin C-terminus; pfam14649"
                     /db_xref="CDD:464236"
     CDS             1..2242
                     /gene="SPG11"
                     /gene_synonym="ALS5; CMT2X; KIAA1840"
                     /coded_by="XM_047433144.1:865..7593"
                     /db_xref="GeneID:80208"
                     /db_xref="HGNC:HGNC:11226"
                     /db_xref="MIM:610844"
ORIGIN      
        1 miidtqlcrg ilfvlsslgw iyifdvvdgt yvahvdlalh kedmcneqqq epakissfts
       61 lkvsqdldva vivsssnsav alnlnlyfrq hpghllceri ledlpiqgpk gvdeddpvns
      121 aynmklakfs fqidrswkaq lsslnetikn sklevsccap wfqdilhles pesgnhstsv
      181 qswafipqdi mhgqynvlqk dhaktsdpgr swkimhiseq eepielkcvs vtgftalftw
      241 evermgytit lwdletqgmq cfslgtkcip vdssgdqqlc fvltenglsl ilfgltqeef
      301 lnrlmihgsa stvdtlchln gwgrcsipih aleagienrq ldtvnfflks kenlfnpssk
      361 ssvsdqfdhl sshlylrnve elipaldllc sairesysep qskhfseqll nltlsflnnq
      421 ikelfihtee ldehlqkgvn iltsyinelr tfmikfpwkl tdaideydvh envpkvkesn
      481 iwkklsfeev iasailnnki peaqtffrid shsaqkleel igiglnlvfd nlkknnikea
      541 sellknmgfd vkgqllkicf yttnknirdf lveilkekny fsekekrtid fvhqveklyl
      601 ghfqenmqiq sfprywikeq dffkhksvld sflkydckde fnkqdhrivl nwalwwdqlt
      661 qesillpris peeyksyspe alwryltarh dwlniilwig efqtqhsyas lqqnkwpllt
      721 vdvinqntsc nnymrneild klarngvfla seledfecfl lrlsriggvi qdtlpvqnyk
      781 tkegwdfhsq filyclehsl qhllyvyldc yklspencpf lekkelheah pwfeflvqcr
      841 qvasnltdpk lifqaslana qiliptnqas vssmlleght llalattmys pggvsqvvqn
      901 eenenclkkv dpqllkmalt pypklktalf pqctppsvlp sditiyhliq slspfdpsrl
      961 fgwqsantla igdawshlph fsspdlvnky aiverlnfay ylhngrpsfa fgtflvqeli
     1021 ksktpkqliq qvgneayvig lssfhipsig aacvcflell gldslklrvd mkvaniilsy
     1081 kcrnedaqys firesvaekl skladgektt teellvllee gtwnsiqqqe ikrlssesss
     1141 qwalvvqfcr lhnmklsisy lrecakandw lqfiihsqlh nyhpaevksl iqyfspviqd
     1201 hlrlafenlp svptskmdsd qvcnkcpqel qgskqemtdl feillqcsee pdswhwllve
     1261 avkqqapils vlasclqgas aisclcvwii tsvednvate amghiqdste dhtwnledls
     1321 viwrtlltrq ksktlirgfq lffkdsplll vmemyelcmf frnykeaeak llefqkslet
     1381 lntaatkvhp vipamwledq vcfllklmlq qcktqyelgk llqlfvereh lfsdgpdvkk
     1441 lcilcqilkd tsiainhtii tsysienlqh ecrsilerlq tdgqfalarr vaelaelpvd
     1501 nlvikeitqe mqtlkhieqw slkqaridfw kkchenfkkn sisskaassf fstqahvace
     1561 hptgwssmee rhllltlagh wlaqedvvpl dkleelekqi wlcritqhtl grnqeetepr
     1621 fsrqistsge lsfdslasef sfsklaalnt skylelnslp sketcenrld wkeqeslnfl
     1681 igrllddgcv heasrvcryf hfynpdvalv lhcralasge asmedlhpei hallqsaell
     1741 eeeapdiplr rvhstsslds qkfvtvpssn evvtnlevlt skclhgknyc rqvlclydla
     1801 kelgcsytdv aaqdgeamlr kilasqqpdr ckraqafist qglkpdtvae lvaeevtrel
     1861 ltssqgtghk qmfnpteesq tflqlttlcq drtlvgmkll dkissvphge lscttellil
     1921 ahhcftltch megiirvlqa ahmltdnhla pseeyglvvr lltgigryne mtyifdllhk
     1981 khyfevlmrk kldpsgtlkt alldyikrcr pgdsekhnmi alcfsmcrei genheaaari
     2041 qlkliesqpw edslkdghql kqlllkaltl mldaaesyak dscvrqaqhc qrltklitlq
     2101 ihflntgqnt mlinlgrhkl mdcilalprf yqasivaeay dfvpdwaeil yqqvilkgdf
     2161 nyleefkqqr llkssifeei skkykqhqpt dmvmenlkkl ltycedvyly yklayehkfy
     2221 eivnvllkdp qtgcclkdml ag
//
LOCUS       XP_016878124            1600 aa            linear   PRI 05-AUG-2025
DEFINITION  spatacsin isoform X2 [Homo sapiens].
ACCESSION   XP_016878124
VERSION     XP_016878124.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022635.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1600
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1600
                     /product="spatacsin isoform X2"
                     /calculated_mol_wt=182340
     CDS             1..1600
                     /gene="SPG11"
                     /gene_synonym="ALS5; CMT2X; KIAA1840"
                     /coded_by="XM_017022635.3:16..4818"
                     /db_xref="GeneID:80208"
                     /db_xref="HGNC:HGNC:11226"
                     /db_xref="MIM:610844"
ORIGIN      
        1 maaeegvasa asaggswgta amgrvlpmll vpvpaeamgq lgsraqlrtq pealgsltaa
       61 gslqvlsltp gsrgggrccl egpfwhflwe dsrnsstpte kpkllalgen yelliyefnl
      121 kdgrcdatil yscsrealqk liddqdisis llslrilsfh nntsllfink cvilhiifpe
      181 rdaairvlnc ftlplpaqav dmiidtqlcr gilfvlsslg wiyifdvvdg tyvahvdlal
      241 hkedmcneqq qepakissft slkvsqdldv avivsssnsa valnlnlyfr qhpghllcer
      301 iledlpiqgp kgvdeddpvn saynmklakf sfqidrswka qlsslnetik nsklevscca
      361 pwfqdilhle spesgnhsts vqswafipqd imhgqynvlq kdhaktsdpg rswkimhise
      421 qeepielkcv svtgftalft wevermgyti tlwdletqgm qcfslgtkci pvdssgdqql
      481 cfvltengls lilfgltqee flnrlmihgs astvdtlchl ngwgrcsipi haleagienr
      541 qldtvnfflk skenlfnpss kssvsdqfdh lsshlylrnv eelipaldll csairesyse
      601 pqskhfseql lnltlsflnn qikelfihte eldehlqkgv niltsyinel rtfmikfpwk
      661 ltdaideydv henvpkvkes niwkklsfee viasailnnk ipeaqtffri dshsaqklee
      721 ligiglnlvf dnlkknnike asellknmgf dvkgqllkic fyttnknird flveilkekn
      781 yfsekekrti dfvhqvekly lghfqenmqi qsfprywike qdffkhksvl dsflkydckd
      841 efnkqdhriv lnwalwwdql tqesillpri speeyksysp ealwryltar hdwlniilwi
      901 gefqtqhsya slqqnkwpll tvdvinqnts cnnymrneil dklarngvfl aseledfecf
      961 llrlsriggv iqdtlpvqny ktkegwdfhs qfilyclehs lqhllyvyld cyklspencp
     1021 flekkelhea hpwfeflvqc rqvasnltdp klifqaslan aqiliptnqa svssmllegh
     1081 tllalattmy spggvsqvvq neenenclkk vdpqllkmal tpypklktal fpqctppsvl
     1141 psditiyhli qslspfdpsr lfgwqsantl aigdawshlp hfsspdlvnk yaiverlnfa
     1201 yylhngrpsf afgtflvqel iksktpkqli qqvgneayvi glssfhipsi gaacvcflel
     1261 lgldslklrv dmkvaniils ykcrnedaqy sfiresvaek lskladgekt tteellvlle
     1321 egtwnsiqqq eikrlssess sqwalvvqfc rlhnmklsis ylrecakand wlqfiihsql
     1381 hnyhpaevks liqyfspviq dhlrlafenl psvptskmds dqvcnkcpqe lqgskqemtd
     1441 lfeillqcse epdswhwllv eavkqqapil svlasclqga saisclcvwi itsvednvat
     1501 eamghiqdst edhtwnledl sviwrtlltr qksktlirgf qlffkdspll lvmemyelcm
     1561 ffrnykeaea kllefqksle tsrvnyetiv tenqilvfqk
//
LOCUS       XP_006720764            1584 aa            linear   PRI 05-AUG-2025
DEFINITION  spatacsin isoform X3 [Homo sapiens].
ACCESSION   XP_006720764
VERSION     XP_006720764.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720701.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1584
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1584
                     /product="spatacsin isoform X3"
                     /calculated_mol_wt=180435
     CDS             1..1584
                     /gene="SPG11"
                     /gene_synonym="ALS5; CMT2X; KIAA1840"
                     /coded_by="XM_006720701.4:16..4770"
                     /db_xref="GeneID:80208"
                     /db_xref="HGNC:HGNC:11226"
                     /db_xref="MIM:610844"
ORIGIN      
        1 maaeegvasa asaggswgta amgrvlpmll vpvpaeamgq lgsraqlrtq pealgsltaa
       61 gslqvlsltp gsrgggrccl egpfwhflwe dsrnsstpte kpkllalgen yelliyefnl
      121 kdgrcdatil yscsrealqk liddqdisis llslrilsfh nntsllfink cvilhiifpe
      181 rdaairvlnc ftlplpaqav dmiidtqlcr gilfvlsslg wiyifdvvdg tyvahvdlal
      241 hkedmcneqq qepakissft slkvsqdldv avivsssnsa valnlnlyfr qhpghllcer
      301 iledlpiqgp kgvdeddpvn saynmklakf sfqidrswka qlsslnetik nsklevscca
      361 pwfqdilhle spesgnhsts vqswafipqd imhgqynvlq kdhaktsdpg rswkimhise
      421 qeepielkcv svtgftalft wevermgyti tlwdletqgm qcfslgtkci pvdssgdqql
      481 cfvltengls lilfgltqee flnrlmihgs astvdtlchl ngwgrcsipi haleagienr
      541 qldtvnfflk skenlfnpss kssvsdqfdh lsshlylrnv eelipaldll csairesyse
      601 pqskhfseql lnltlsflnn qikelfihte eldehlqkgv niltsyinel rtfmikfpwk
      661 ltdaideydv henvpkvkes niwkklsfee viasailnnk ipeaqtffri dshsaqklee
      721 ligiglnlvf dnlkknnike asellknmgf dvkgqllkic fyttnknird flveilkekn
      781 yfsekekrti dfvhqvekly lghfqenmqi qsfprywike qdffkhksvl dsflkydckd
      841 efnkqdhriv lnwalwwdql tqesillpri speeyksysp ealwryltar hdwlniilwi
      901 gefqtqhsya slqqnkwpll tvdvinqnts cnnymrneil dklarngvfl aseledfecf
      961 llrlsriggv iqdtlpvqny ktkegwdfhs qfilyclehs lqhllyvyld cyklspencp
     1021 flekkelhea hpwfeflvqc rqvasnltdp klifqaslan aqiliptnqa svssmllegh
     1081 tllalattmy spggvsqvvq neenenclkk vdpqllkmal tpypklktal fpqctppsvl
     1141 psditiyhli qslspfdpsr lfgwqsantl aigdawshlp hfsspdlvnk yaiverlnfa
     1201 yylhngrpsf afgtflvqel iksktpkqli qqvgneayvi glssfhipsi gaacvcflel
     1261 lgldslklrv dmkvaniils ykcrnedaqy sfiresvaek lskladgekt tteellvlle
     1321 egtwnsiqqq eikrlssess sqwalvvqfc rlhnmklsis ylrecakand wlqfiihsql
     1381 hnyhpaevks liqyfspviq dhlrlafenl psvptskmds dqvcnkcpqe lqgskqemtd
     1441 lfeillqcse epdswhwllv eavkqqapil svlasclqga saisclcvwi itsvednvat
     1501 eamghiqdst edhtwnledl sviwrtlltr qksktlirgf qlffkdspll lvmemyelcm
     1561 ffrnykeaea kllefqksle tvqm
//
LOCUS       XP_047289101            1535 aa            linear   PRI 05-AUG-2025
DEFINITION  spatacsin isoform X4 [Homo sapiens].
ACCESSION   XP_047289101
VERSION     XP_047289101.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433145.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1535
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1535
                     /product="spatacsin isoform X4"
                     /calculated_mol_wt=174845
     CDS             1..1535
                     /gene="SPG11"
                     /gene_synonym="ALS5; CMT2X; KIAA1840"
                     /coded_by="XM_047433145.1:16..4623"
                     /db_xref="GeneID:80208"
                     /db_xref="HGNC:HGNC:11226"
                     /db_xref="MIM:610844"
ORIGIN      
        1 maaeegvasa asaggswgta amgrvlpmll vpvpaeamgq lgsraqlrtq pealgsltaa
       61 gslqvlsltp gsrgggrccl egpfwhflwe dsrnsstpte kpkllalgen yelliyefnl
      121 kdgrcdatil yscsrealqk liddqdisis llslrilsfh nntsllfink cvilhiifpe
      181 rdaairvlnc ftlplpaqav dmiidtqlcr gilfvlsslg wiyifdvvdg tyvahvdlal
      241 hkedmcneqq qepakissft slkvsqdldv avivsssnsa valnlnlyfr qhpghllcer
      301 iledlpiqgp kgvdeddpvn saynmklakf sfqidrswka qlsslnetik nsklevscca
      361 pwfqdilhle spesgnhsts vqswafipqd imhgqynvlq kdhaktsdpg rswkimhise
      421 qeepielkcv svtgftalft wevermgyti tlwdletqgm qcfslgtkci pvdssgdqql
      481 cfvltengls lilfgltqee flnrlmihgs astvdtlchl ngwgrcsipi haleagienr
      541 qldtvnfflk skenlfnpss kssvsdqfdh lsshlylrnv eelipaldll csairesyse
      601 pqskhfseql lnltlsflnn qikelfihte eldehlqkgv niltsyinel rtfmikfpwk
      661 ltdaideydv henvpkvkes niwkklsfee viasailnnk ipeaqtffri dshsaqklee
      721 ligiglnlvf dnlkknnike asellknmgf dvkgqllkic fyttnknird flveilkekn
      781 yfsekekrti dfvhqvekly lghfqenmqi qsfprywike qdffkhksvl dsflkydckd
      841 efnkqdhriv lnwalwwdql tqesillpri speeyksysp ealwryltar hdwlniilwi
      901 gefqtqhsya slqqnkwpll tvdvinqnts cnnymrneil dklarngvfl aseledfecf
      961 llrlsriggv iqdtlpvqny ktkegwdfhs qfilyclehs lqhllyvyld cyklspencp
     1021 flekkelhea hpwfeflvqc rqvasnltdp klifqaslan aqiliptnqa svssmllegh
     1081 tllalattmy spggvsqvvq neenenclkk vdpqllkmal tpypklktal fpqctppsvl
     1141 psditiyhli qslspfdpsr lfgwqsantl aigdawshlp hfsspdlvnk yaiverlnfa
     1201 yylhngrpsf afgtflvqel iksktpkqli qqvgneayvi glssfhipsi gaacvcflel
     1261 lgldslklrv dmkvaniils ykcrnedaqy sfiresvaek lskladgekt tteellvlle
     1321 egtwnsiqqq eikrlssess sqwalvvqfc rlhnmklsis ylrecakand wlqfiihsql
     1381 hnyhpaevks liqyfspviq dhlrlafenl psvptskmds dqvcnkcpqe lqgskqemtd
     1441 lfeillqcse epdswhwllv eavkqqapil svlasclqvr imrslkvpvp flvsvfgssl
     1501 lwrtmlqlkq wdtfrtqqrt ipgtlrifqs sgehy
//
LOCUS       XP_047289102            1402 aa            linear   PRI 05-AUG-2025
DEFINITION  spatacsin isoform X5 [Homo sapiens].
ACCESSION   XP_047289102
VERSION     XP_047289102.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433146.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1402
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1402
                     /product="spatacsin isoform X5"
                     /calculated_mol_wt=159525
     Region          1054..1346
                     /region_name="Spatacsin_C"
                     /note="Spatacsin C-terminus; pfam14649"
                     /db_xref="CDD:464236"
     CDS             1..1402
                     /gene="SPG11"
                     /gene_synonym="ALS5; CMT2X; KIAA1840"
                     /coded_by="XM_047433146.1:105..4313"
                     /db_xref="GeneID:80208"
                     /db_xref="HGNC:HGNC:11226"
                     /db_xref="MIM:610844"
ORIGIN      
        1 mstltvtnpk lifqaslana qiliptnqas vssmlleght llalattmys pggvsqvvqn
       61 eenenclkkv dpqllkmalt pypklktalf pqctppsvlp sditiyhliq slspfdpsrl
      121 fgwqsantla igdawshlph fsspdlvnky aiverlnfay ylhngrpsfa fgtflvqeli
      181 ksktpkqliq qvgneayvig lssfhipsig aacvcflell gldslklrvd mkvaniilsy
      241 kcrnedaqys firesvaekl skladgektt teellvllee gtwnsiqqqe ikrlssesss
      301 qwalvvqfcr lhnmklsisy lrecakandw lqfiihsqlh nyhpaevksl iqyfspviqd
      361 hlrlafenlp svptskmdsd qvcnkcpqel qgskqemtdl feillqcsee pdswhwllve
      421 avkqqapils vlasclqgas aisclcvwii tsvednvate amghiqdste dhtwnledls
      481 viwrtlltrq ksktlirgfq lffkdsplll vmemyelcmf frnykeaeak llefqkslet
      541 lntaatkvhp vipamwledq vcfllklmlq qcktqyelgk llqlfvereh lfsdgpdvkk
      601 lcilcqilkd tsiainhtii tsysienlqh ecrsilerlq tdgqfalarr vaelaelpvd
      661 nlvikeitqe mqtlkhieqw slkqaridfw kkchenfkkn sisskaassf fstqahvace
      721 hptgwssmee rhllltlagh wlaqedvvpl dkleelekqi wlcritqhtl grnqeetepr
      781 fsrqistsge lsfdslasef sfsklaalnt skylelnslp sketcenrld wkeqeslnfl
      841 igrllddgcv heasrvcryf hfynpdvalv lhcralasge asmedlhpei hallqsaell
      901 eeeapdiplr rvhstsslds qkfvtvpssn evvtnlevlt skclhgknyc rqvlclydla
      961 kelgcsytdv aaqdgeamlr kilasqqpdr ckraqafist qglkpdtvae lvaeevtrel
     1021 ltssqgtghk qmfnpteesq tflqlttlcq drtlvgmkll dkissvphge lscttellil
     1081 ahhcftltch megiirvlqa ahmltdnhla pseeyglvvr lltgigryne mtyifdllhk
     1141 khyfevlmrk kldpsgtlkt alldyikrcr pgdsekhnmi alcfsmcrei genheaaari
     1201 qlkliesqpw edslkdghql kqlllkaltl mldaaesyak dscvrqaqhc qrltklitlq
     1261 ihflntgqnt mlinlgrhkl mdcilalprf yqasivaeay dfvpdwaeil yqqvilkgdf
     1321 nyleefkqqr llkssifeei skkykqhqpt dmvmenlkkl ltycedvyly yklayehkfy
     1381 eivnvllkdp qtgcclkdml ag
//
LOCUS       XP_011520396             305 aa            linear   PRI 05-AUG-2025
DEFINITION  superkiller complex protein 8 isoform X1 [Homo sapiens].
ACCESSION   XP_011520396
VERSION     XP_011520396.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522094.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..305
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..305
                     /product="superkiller complex protein 8 isoform X1"
                     /calculated_mol_wt=33450
     Region          <6..302
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          19..62
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          68..105
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          110..146
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          152..188
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          193..229
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          236..271
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..305
                     /gene="SKIC8"
                     /gene_synonym="REC14; SKI8; WDR61"
                     /coded_by="XM_011522094.3:156..1073"
                     /db_xref="GeneID:80349"
                     /db_xref="HGNC:HGNC:30300"
                     /db_xref="MIM:609540"
ORIGIN      
        1 mtnqygilfk qeqahddaiw svawgtnkke nsetvvtgsl ddlvkvwkwr derldlqwsl
       61 eghqlgvvsv dishtlpiaa sssldahirl wdlengkqik sidagpvdaw tlafspdsqy
      121 latgthvgkv nifgvesgkk eysldtrgkf ilsiayspdg kylasgaidg iinifdiatg
      181 kllhtlegha mpirsltfsp dsqllvtasd dgyikiydvq hanlagtlsg haswvlnvaf
      241 cpddthfvss ssdksvkvwd vgtrtcvhtf fdhqdqvwgv kyngngskiv svgddqeihi
      301 ydcpi
//
LOCUS       XP_016878126             270 aa            linear   PRI 05-AUG-2025
DEFINITION  superkiller complex protein 8 isoform X2 [Homo sapiens].
ACCESSION   XP_016878126
VERSION     XP_016878126.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022637.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..270
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..270
                     /product="superkiller complex protein 8 isoform X2"
                     /calculated_mol_wt=29741
     Region          <13..249
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          19..62
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          68..105
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          110..145
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          152..187
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          193..229
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..270
                     /gene="SKIC8"
                     /gene_synonym="REC14; SKI8; WDR61"
                     /coded_by="XM_017022637.3:88..900"
                     /db_xref="GeneID:80349"
                     /db_xref="HGNC:HGNC:30300"
                     /db_xref="MIM:609540"
ORIGIN      
        1 mtnqygilfk qeqahddaiw svawgtnkke nsetvvtgsl ddlvkvwkwr derldlqwsl
       61 eghqlgvvsv dishtlpiaa sssldahirl wdlengkqik sidagpvdaw tlafspdsqy
      121 latgthvgkv nifgvesgkk eysldtrgkf ilsiayspdg kylasgaidg iinifdiatg
      181 kllhtlegha mpirsltfsp dsqllvtasd dgyikiydvq hanlagtlsg haswvlnvaf
      241 cpddthfvsr sqcwsglgwp rqlesrrwtt
//
LOCUS       XP_047289103             534 aa            linear   PRI 05-AUG-2025
DEFINITION  CD276 antigen isoform X1 [Homo sapiens].
ACCESSION   XP_047289103
VERSION     XP_047289103.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433147.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..534
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..534
                     /product="CD276 antigen isoform X1"
                     /calculated_mol_wt=57105
     Region          32..142
                     /region_name="IgV_B7-H3"
                     /note="Immunoglobulin Variable (IgV) domain of B7-H3, a
                     member of the B7 family of immune checkpoint molecules;
                     cd20934"
                     /db_xref="CDD:409528"
     Region          32..51
                     /region_name="FR1"
                     /note="FR1 [structural motif]"
                     /db_xref="CDD:409528"
     Region          32..35
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409528"
     Region          37..41
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409528"
     Region          44..51
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409528"
     Region          52..60
                     /region_name="CDR1"
                     /note="CDR1 [structural motif]"
                     /db_xref="CDD:409528"
     Region          62..72
                     /region_name="FR2"
                     /note="FR2 [structural motif]"
                     /db_xref="CDD:409528"
     Region          62..69
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409528"
     Region          74..86
                     /region_name="CDR2"
                     /note="CDR2 [structural motif]"
                     /db_xref="CDD:409528"
     Region          75..80
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409528"
     Region          89..127
                     /region_name="FR3"
                     /note="FR3 [structural motif]"
                     /db_xref="CDD:409528"
     Region          92..98
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409528"
     Region          104..110
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409528"
     Region          119..127
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409528"
     Region          128..130
                     /region_name="CDR3"
                     /note="CDR3 [structural motif]"
                     /db_xref="CDD:409528"
     Region          130..139
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409528"
     Region          131..142
                     /region_name="FR4"
                     /note="FR4 [structural motif]"
                     /db_xref="CDD:409528"
     Region          144..224
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     Region          250..360
                     /region_name="IgV_B7-H3"
                     /note="Immunoglobulin Variable (IgV) domain of B7-H3, a
                     member of the B7 family of immune checkpoint molecules;
                     cd20934"
                     /db_xref="CDD:409528"
     Region          250..269
                     /region_name="FR1"
                     /note="FR1 [structural motif]"
                     /db_xref="CDD:409528"
     Region          250..253
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409528"
     Region          255..259
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409528"
     Region          262..269
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409528"
     Region          270..278
                     /region_name="CDR1"
                     /note="CDR1 [structural motif]"
                     /db_xref="CDD:409528"
     Region          280..290
                     /region_name="FR2"
                     /note="FR2 [structural motif]"
                     /db_xref="CDD:409528"
     Region          280..287
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409528"
     Region          292..304
                     /region_name="CDR2"
                     /note="CDR2 [structural motif]"
                     /db_xref="CDD:409528"
     Region          293..298
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409528"
     Region          301..304
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409528"
     Region          307..345
                     /region_name="FR3"
                     /note="FR3 [structural motif]"
                     /db_xref="CDD:409528"
     Region          310..316
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409528"
     Region          322..328
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409528"
     Region          337..345
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409528"
     Region          346..348
                     /region_name="CDR3"
                     /note="CDR3 [structural motif]"
                     /db_xref="CDD:409528"
     Region          348..357
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409528"
     Region          349..360
                     /region_name="FR4"
                     /note="FR4 [structural motif]"
                     /db_xref="CDD:409528"
     Region          362..442
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     CDS             1..534
                     /gene="CD276"
                     /gene_synonym="4Ig-B7-H3; B7-H3; B7H3; B7RP-2"
                     /coded_by="XM_047433147.1:11539..13143"
                     /db_xref="GeneID:80381"
                     /db_xref="HGNC:HGNC:19137"
                     /db_xref="MIM:605715"
ORIGIN      
        1 mlrrrgspgm gvhvgaalga lwfcltgale vqvpedpvva lvgtdatlcc sfspepgfsl
       61 aqlnliwqlt dtkqlvhsfa egqdqgsaya nrtalfpdll aqgnaslrlq rvrvadegsf
      121 tcfvsirdfg saavslqvaa pyskpsmtle pnkdlrpgdt vtitcssyqg ypeaevfwqd
      181 gqgvpltgnv ttsqmaneqg lfdvhsilrv vlgangtysc lvrnpvlqqd ahssvtitpq
      241 rsptgavevq vpedpvvalv gtdatlrcsf spepgfslaq lnliwqltdt kqlvhsfteg
      301 rdqgsayanr talfpdllaq gnaslrlqrv rvadegsftc fvsirdfgsa avslqvaapy
      361 skpsmtlepn kdlrpgdtvt itcssyrgyp eaevfwqdgq gvpltgnvtt sqmaneqglf
      421 dvhsvlrvvl gangtysclv rnpvlqqdah gsvtitgqpm tfppealwvt vglsvclial
      481 lvalafvcwr kikqsceeen agaedqdgeg egsktalqpl khsdskeddg qeia
//
LOCUS       XP_005254757             534 aa            linear   PRI 05-AUG-2025
DEFINITION  CD276 antigen isoform X1 [Homo sapiens].
ACCESSION   XP_005254757
VERSION     XP_005254757.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254700.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..534
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..534
                     /product="CD276 antigen isoform X1"
                     /calculated_mol_wt=57105
     Region          32..142
                     /region_name="IgV_B7-H3"
                     /note="Immunoglobulin Variable (IgV) domain of B7-H3, a
                     member of the B7 family of immune checkpoint molecules;
                     cd20934"
                     /db_xref="CDD:409528"
     Region          32..51
                     /region_name="FR1"
                     /note="FR1 [structural motif]"
                     /db_xref="CDD:409528"
     Region          32..35
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409528"
     Region          37..41
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409528"
     Region          44..51
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409528"
     Region          52..60
                     /region_name="CDR1"
                     /note="CDR1 [structural motif]"
                     /db_xref="CDD:409528"
     Region          62..72
                     /region_name="FR2"
                     /note="FR2 [structural motif]"
                     /db_xref="CDD:409528"
     Region          62..69
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409528"
     Region          74..86
                     /region_name="CDR2"
                     /note="CDR2 [structural motif]"
                     /db_xref="CDD:409528"
     Region          75..80
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409528"
     Region          89..127
                     /region_name="FR3"
                     /note="FR3 [structural motif]"
                     /db_xref="CDD:409528"
     Region          92..98
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409528"
     Region          104..110
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409528"
     Region          119..127
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409528"
     Region          128..130
                     /region_name="CDR3"
                     /note="CDR3 [structural motif]"
                     /db_xref="CDD:409528"
     Region          130..139
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409528"
     Region          131..142
                     /region_name="FR4"
                     /note="FR4 [structural motif]"
                     /db_xref="CDD:409528"
     Region          144..224
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     Region          250..360
                     /region_name="IgV_B7-H3"
                     /note="Immunoglobulin Variable (IgV) domain of B7-H3, a
                     member of the B7 family of immune checkpoint molecules;
                     cd20934"
                     /db_xref="CDD:409528"
     Region          250..269
                     /region_name="FR1"
                     /note="FR1 [structural motif]"
                     /db_xref="CDD:409528"
     Region          250..253
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409528"
     Region          255..259
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409528"
     Region          262..269
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409528"
     Region          270..278
                     /region_name="CDR1"
                     /note="CDR1 [structural motif]"
                     /db_xref="CDD:409528"
     Region          280..290
                     /region_name="FR2"
                     /note="FR2 [structural motif]"
                     /db_xref="CDD:409528"
     Region          280..287
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409528"
     Region          292..304
                     /region_name="CDR2"
                     /note="CDR2 [structural motif]"
                     /db_xref="CDD:409528"
     Region          293..298
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409528"
     Region          301..304
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409528"
     Region          307..345
                     /region_name="FR3"
                     /note="FR3 [structural motif]"
                     /db_xref="CDD:409528"
     Region          310..316
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409528"
     Region          322..328
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409528"
     Region          337..345
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409528"
     Region          346..348
                     /region_name="CDR3"
                     /note="CDR3 [structural motif]"
                     /db_xref="CDD:409528"
     Region          348..357
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409528"
     Region          349..360
                     /region_name="FR4"
                     /note="FR4 [structural motif]"
                     /db_xref="CDD:409528"
     Region          362..442
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     CDS             1..534
                     /gene="CD276"
                     /gene_synonym="4Ig-B7-H3; B7-H3; B7H3; B7RP-2"
                     /coded_by="XM_005254700.5:640..2244"
                     /db_xref="GeneID:80381"
                     /db_xref="HGNC:HGNC:19137"
                     /db_xref="MIM:605715"
ORIGIN      
        1 mlrrrgspgm gvhvgaalga lwfcltgale vqvpedpvva lvgtdatlcc sfspepgfsl
       61 aqlnliwqlt dtkqlvhsfa egqdqgsaya nrtalfpdll aqgnaslrlq rvrvadegsf
      121 tcfvsirdfg saavslqvaa pyskpsmtle pnkdlrpgdt vtitcssyqg ypeaevfwqd
      181 gqgvpltgnv ttsqmaneqg lfdvhsilrv vlgangtysc lvrnpvlqqd ahssvtitpq
      241 rsptgavevq vpedpvvalv gtdatlrcsf spepgfslaq lnliwqltdt kqlvhsfteg
      301 rdqgsayanr talfpdllaq gnaslrlqrv rvadegsftc fvsirdfgsa avslqvaapy
      361 skpsmtlepn kdlrpgdtvt itcssyrgyp eaevfwqdgq gvpltgnvtt sqmaneqglf
      421 dvhsvlrvvl gangtysclv rnpvlqqdah gsvtitgqpm tfppealwvt vglsvclial
      481 lvalafvcwr kikqsceeen agaedqdgeg egsktalqpl khsdskeddg qeia
//
LOCUS       XP_011520397             534 aa            linear   PRI 05-AUG-2025
DEFINITION  CD276 antigen isoform X1 [Homo sapiens].
ACCESSION   XP_011520397
VERSION     XP_011520397.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522095.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..534
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..534
                     /product="CD276 antigen isoform X1"
                     /calculated_mol_wt=57105
     Region          32..142
                     /region_name="IgV_B7-H3"
                     /note="Immunoglobulin Variable (IgV) domain of B7-H3, a
                     member of the B7 family of immune checkpoint molecules;
                     cd20934"
                     /db_xref="CDD:409528"
     Region          32..51
                     /region_name="FR1"
                     /note="FR1 [structural motif]"
                     /db_xref="CDD:409528"
     Region          32..35
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409528"
     Region          37..41
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409528"
     Region          44..51
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409528"
     Region          52..60
                     /region_name="CDR1"
                     /note="CDR1 [structural motif]"
                     /db_xref="CDD:409528"
     Region          62..72
                     /region_name="FR2"
                     /note="FR2 [structural motif]"
                     /db_xref="CDD:409528"
     Region          62..69
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409528"
     Region          74..86
                     /region_name="CDR2"
                     /note="CDR2 [structural motif]"
                     /db_xref="CDD:409528"
     Region          75..80
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409528"
     Region          89..127
                     /region_name="FR3"
                     /note="FR3 [structural motif]"
                     /db_xref="CDD:409528"
     Region          92..98
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409528"
     Region          104..110
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409528"
     Region          119..127
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409528"
     Region          128..130
                     /region_name="CDR3"
                     /note="CDR3 [structural motif]"
                     /db_xref="CDD:409528"
     Region          130..139
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409528"
     Region          131..142
                     /region_name="FR4"
                     /note="FR4 [structural motif]"
                     /db_xref="CDD:409528"
     Region          144..224
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     Region          250..360
                     /region_name="IgV_B7-H3"
                     /note="Immunoglobulin Variable (IgV) domain of B7-H3, a
                     member of the B7 family of immune checkpoint molecules;
                     cd20934"
                     /db_xref="CDD:409528"
     Region          250..269
                     /region_name="FR1"
                     /note="FR1 [structural motif]"
                     /db_xref="CDD:409528"
     Region          250..253
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409528"
     Region          255..259
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409528"
     Region          262..269
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409528"
     Region          270..278
                     /region_name="CDR1"
                     /note="CDR1 [structural motif]"
                     /db_xref="CDD:409528"
     Region          280..290
                     /region_name="FR2"
                     /note="FR2 [structural motif]"
                     /db_xref="CDD:409528"
     Region          280..287
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409528"
     Region          292..304
                     /region_name="CDR2"
                     /note="CDR2 [structural motif]"
                     /db_xref="CDD:409528"
     Region          293..298
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409528"
     Region          301..304
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409528"
     Region          307..345
                     /region_name="FR3"
                     /note="FR3 [structural motif]"
                     /db_xref="CDD:409528"
     Region          310..316
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409528"
     Region          322..328
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409528"
     Region          337..345
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409528"
     Region          346..348
                     /region_name="CDR3"
                     /note="CDR3 [structural motif]"
                     /db_xref="CDD:409528"
     Region          348..357
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409528"
     Region          349..360
                     /region_name="FR4"
                     /note="FR4 [structural motif]"
                     /db_xref="CDD:409528"
     Region          362..442
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     CDS             1..534
                     /gene="CD276"
                     /gene_synonym="4Ig-B7-H3; B7-H3; B7H3; B7RP-2"
                     /coded_by="XM_011522095.3:740..2344"
                     /db_xref="GeneID:80381"
                     /db_xref="HGNC:HGNC:19137"
                     /db_xref="MIM:605715"
ORIGIN      
        1 mlrrrgspgm gvhvgaalga lwfcltgale vqvpedpvva lvgtdatlcc sfspepgfsl
       61 aqlnliwqlt dtkqlvhsfa egqdqgsaya nrtalfpdll aqgnaslrlq rvrvadegsf
      121 tcfvsirdfg saavslqvaa pyskpsmtle pnkdlrpgdt vtitcssyqg ypeaevfwqd
      181 gqgvpltgnv ttsqmaneqg lfdvhsilrv vlgangtysc lvrnpvlqqd ahssvtitpq
      241 rsptgavevq vpedpvvalv gtdatlrcsf spepgfslaq lnliwqltdt kqlvhsfteg
      301 rdqgsayanr talfpdllaq gnaslrlqrv rvadegsftc fvsirdfgsa avslqvaapy
      361 skpsmtlepn kdlrpgdtvt itcssyrgyp eaevfwqdgq gvpltgnvtt sqmaneqglf
      421 dvhsvlrvvl gangtysclv rnpvlqqdah gsvtitgqpm tfppealwvt vglsvclial
      481 lvalafvcwr kikqsceeen agaedqdgeg egsktalqpl khsdskeddg qeia
//
LOCUS       XP_047289104             534 aa            linear   PRI 05-AUG-2025
DEFINITION  CD276 antigen isoform X1 [Homo sapiens].
ACCESSION   XP_047289104
VERSION     XP_047289104.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433148.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..534
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..534
                     /product="CD276 antigen isoform X1"
                     /calculated_mol_wt=57105
     Region          32..142
                     /region_name="IgV_B7-H3"
                     /note="Immunoglobulin Variable (IgV) domain of B7-H3, a
                     member of the B7 family of immune checkpoint molecules;
                     cd20934"
                     /db_xref="CDD:409528"
     Region          32..51
                     /region_name="FR1"
                     /note="FR1 [structural motif]"
                     /db_xref="CDD:409528"
     Region          32..35
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409528"
     Region          37..41
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409528"
     Region          44..51
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409528"
     Region          52..60
                     /region_name="CDR1"
                     /note="CDR1 [structural motif]"
                     /db_xref="CDD:409528"
     Region          62..72
                     /region_name="FR2"
                     /note="FR2 [structural motif]"
                     /db_xref="CDD:409528"
     Region          62..69
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409528"
     Region          74..86
                     /region_name="CDR2"
                     /note="CDR2 [structural motif]"
                     /db_xref="CDD:409528"
     Region          75..80
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409528"
     Region          89..127
                     /region_name="FR3"
                     /note="FR3 [structural motif]"
                     /db_xref="CDD:409528"
     Region          92..98
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409528"
     Region          104..110
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409528"
     Region          119..127
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409528"
     Region          128..130
                     /region_name="CDR3"
                     /note="CDR3 [structural motif]"
                     /db_xref="CDD:409528"
     Region          130..139
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409528"
     Region          131..142
                     /region_name="FR4"
                     /note="FR4 [structural motif]"
                     /db_xref="CDD:409528"
     Region          144..224
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     Region          250..360
                     /region_name="IgV_B7-H3"
                     /note="Immunoglobulin Variable (IgV) domain of B7-H3, a
                     member of the B7 family of immune checkpoint molecules;
                     cd20934"
                     /db_xref="CDD:409528"
     Region          250..269
                     /region_name="FR1"
                     /note="FR1 [structural motif]"
                     /db_xref="CDD:409528"
     Region          250..253
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409528"
     Region          255..259
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409528"
     Region          262..269
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409528"
     Region          270..278
                     /region_name="CDR1"
                     /note="CDR1 [structural motif]"
                     /db_xref="CDD:409528"
     Region          280..290
                     /region_name="FR2"
                     /note="FR2 [structural motif]"
                     /db_xref="CDD:409528"
     Region          280..287
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409528"
     Region          292..304
                     /region_name="CDR2"
                     /note="CDR2 [structural motif]"
                     /db_xref="CDD:409528"
     Region          293..298
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409528"
     Region          301..304
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409528"
     Region          307..345
                     /region_name="FR3"
                     /note="FR3 [structural motif]"
                     /db_xref="CDD:409528"
     Region          310..316
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409528"
     Region          322..328
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409528"
     Region          337..345
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409528"
     Region          346..348
                     /region_name="CDR3"
                     /note="CDR3 [structural motif]"
                     /db_xref="CDD:409528"
     Region          348..357
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409528"
     Region          349..360
                     /region_name="FR4"
                     /note="FR4 [structural motif]"
                     /db_xref="CDD:409528"
     Region          362..442
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     CDS             1..534
                     /gene="CD276"
                     /gene_synonym="4Ig-B7-H3; B7-H3; B7H3; B7RP-2"
                     /coded_by="XM_047433148.1:11885..13489"
                     /db_xref="GeneID:80381"
                     /db_xref="HGNC:HGNC:19137"
                     /db_xref="MIM:605715"
ORIGIN      
        1 mlrrrgspgm gvhvgaalga lwfcltgale vqvpedpvva lvgtdatlcc sfspepgfsl
       61 aqlnliwqlt dtkqlvhsfa egqdqgsaya nrtalfpdll aqgnaslrlq rvrvadegsf
      121 tcfvsirdfg saavslqvaa pyskpsmtle pnkdlrpgdt vtitcssyqg ypeaevfwqd
      181 gqgvpltgnv ttsqmaneqg lfdvhsilrv vlgangtysc lvrnpvlqqd ahssvtitpq
      241 rsptgavevq vpedpvvalv gtdatlrcsf spepgfslaq lnliwqltdt kqlvhsfteg
      301 rdqgsayanr talfpdllaq gnaslrlqrv rvadegsftc fvsirdfgsa avslqvaapy
      361 skpsmtlepn kdlrpgdtvt itcssyrgyp eaevfwqdgq gvpltgnvtt sqmaneqglf
      421 dvhsvlrvvl gangtysclv rnpvlqqdah gsvtitgqpm tfppealwvt vglsvclial
      481 lvalafvcwr kikqsceeen agaedqdgeg egsktalqpl khsdskeddg qeia
//
LOCUS       XP_016878127             534 aa            linear   PRI 05-AUG-2025
DEFINITION  CD276 antigen isoform X1 [Homo sapiens].
ACCESSION   XP_016878127
VERSION     XP_016878127.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022638.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..534
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..534
                     /product="CD276 antigen isoform X1"
                     /calculated_mol_wt=57105
     Region          32..142
                     /region_name="IgV_B7-H3"
                     /note="Immunoglobulin Variable (IgV) domain of B7-H3, a
                     member of the B7 family of immune checkpoint molecules;
                     cd20934"
                     /db_xref="CDD:409528"
     Region          32..51
                     /region_name="FR1"
                     /note="FR1 [structural motif]"
                     /db_xref="CDD:409528"
     Region          32..35
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409528"
     Region          37..41
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409528"
     Region          44..51
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409528"
     Region          52..60
                     /region_name="CDR1"
                     /note="CDR1 [structural motif]"
                     /db_xref="CDD:409528"
     Region          62..72
                     /region_name="FR2"
                     /note="FR2 [structural motif]"
                     /db_xref="CDD:409528"
     Region          62..69
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409528"
     Region          74..86
                     /region_name="CDR2"
                     /note="CDR2 [structural motif]"
                     /db_xref="CDD:409528"
     Region          75..80
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409528"
     Region          89..127
                     /region_name="FR3"
                     /note="FR3 [structural motif]"
                     /db_xref="CDD:409528"
     Region          92..98
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409528"
     Region          104..110
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409528"
     Region          119..127
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409528"
     Region          128..130
                     /region_name="CDR3"
                     /note="CDR3 [structural motif]"
                     /db_xref="CDD:409528"
     Region          130..139
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409528"
     Region          131..142
                     /region_name="FR4"
                     /note="FR4 [structural motif]"
                     /db_xref="CDD:409528"
     Region          144..224
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     Region          250..360
                     /region_name="IgV_B7-H3"
                     /note="Immunoglobulin Variable (IgV) domain of B7-H3, a
                     member of the B7 family of immune checkpoint molecules;
                     cd20934"
                     /db_xref="CDD:409528"
     Region          250..269
                     /region_name="FR1"
                     /note="FR1 [structural motif]"
                     /db_xref="CDD:409528"
     Region          250..253
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409528"
     Region          255..259
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409528"
     Region          262..269
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409528"
     Region          270..278
                     /region_name="CDR1"
                     /note="CDR1 [structural motif]"
                     /db_xref="CDD:409528"
     Region          280..290
                     /region_name="FR2"
                     /note="FR2 [structural motif]"
                     /db_xref="CDD:409528"
     Region          280..287
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409528"
     Region          292..304
                     /region_name="CDR2"
                     /note="CDR2 [structural motif]"
                     /db_xref="CDD:409528"
     Region          293..298
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409528"
     Region          301..304
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409528"
     Region          307..345
                     /region_name="FR3"
                     /note="FR3 [structural motif]"
                     /db_xref="CDD:409528"
     Region          310..316
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409528"
     Region          322..328
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409528"
     Region          337..345
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409528"
     Region          346..348
                     /region_name="CDR3"
                     /note="CDR3 [structural motif]"
                     /db_xref="CDD:409528"
     Region          348..357
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409528"
     Region          349..360
                     /region_name="FR4"
                     /note="FR4 [structural motif]"
                     /db_xref="CDD:409528"
     Region          362..442
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     CDS             1..534
                     /gene="CD276"
                     /gene_synonym="4Ig-B7-H3; B7-H3; B7H3; B7RP-2"
                     /coded_by="XM_017022638.2:175..1779"
                     /db_xref="GeneID:80381"
                     /db_xref="HGNC:HGNC:19137"
                     /db_xref="MIM:605715"
ORIGIN      
        1 mlrrrgspgm gvhvgaalga lwfcltgale vqvpedpvva lvgtdatlcc sfspepgfsl
       61 aqlnliwqlt dtkqlvhsfa egqdqgsaya nrtalfpdll aqgnaslrlq rvrvadegsf
      121 tcfvsirdfg saavslqvaa pyskpsmtle pnkdlrpgdt vtitcssyqg ypeaevfwqd
      181 gqgvpltgnv ttsqmaneqg lfdvhsilrv vlgangtysc lvrnpvlqqd ahssvtitpq
      241 rsptgavevq vpedpvvalv gtdatlrcsf spepgfslaq lnliwqltdt kqlvhsfteg
      301 rdqgsayanr talfpdllaq gnaslrlqrv rvadegsftc fvsirdfgsa avslqvaapy
      361 skpsmtlepn kdlrpgdtvt itcssyrgyp eaevfwqdgq gvpltgnvtt sqmaneqglf
      421 dvhsvlrvvl gangtysclv rnpvlqqdah gsvtitgqpm tfppealwvt vglsvclial
      481 lvalafvcwr kikqsceeen agaedqdgeg egsktalqpl khsdskeddg qeia
//
LOCUS       XP_016878131             396 aa            linear   PRI 05-AUG-2025
DEFINITION  alpha-2,8-sialyltransferase 8B isoform X1 [Homo sapiens].
ACCESSION   XP_016878131
VERSION     XP_016878131.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022642.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..396
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..396
                     /product="alpha-2,8-sialyltransferase 8B isoform X1"
                     /calculated_mol_wt=44671
     Region          112..389
                     /region_name="GT29_ST8SIA2"
                     /note="alpha-N-acetylneuraminide
                     alpha-2,8-sialyltransferase 2; cd23987"
                     /db_xref="CDD:467715"
     Site            order(182..184,205..206,227,315..317,335..336,349..351,
                     367)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:467715"
     CDS             1..396
                     /gene="ST8SIA2"
                     /gene_synonym="HsT19690; SIAT8-B; SIAT8B; ST8SIA-II;
                     ST8SiaII; STX"
                     /coded_by="XM_017022642.2:4390..5580"
                     /db_xref="GeneID:8128"
                     /db_xref="HGNC:HGNC:10870"
                     /db_xref="MIM:602546"
ORIGIN      
        1 mfslpfllft vhpsegvrkl slnilrvkve lgtipktvfs fatsfyfysv vskrnsggrg
       61 tirsavnslh sksnraevvi ngssspavvd rsnesikhni qpasskwrhn qtlslrirkq
      121 ilkfldaekd isvlkgtlkp gdiihyifdr dstmnvsqnl yellprtspl knkhfgtcai
      181 vgnsgvllns gcgqeidahs fvircnlapv qeyardvglk tdlvtmnpsv iqrafedlvn
      241 atwrekllqr lhslngsilw ipafmarggk ervewvneli lkhhvnvrta ypslrllhav
      301 rgywltnkvh ikrpttgllm ytlatrfckq iylygfwpfp ldqnqnpvky hyydslkygy
      361 tsqasphtmp lefkalkslh eqgalkltvg qcdgat
//
LOCUS       XP_005272603             360 aa            linear   PRI 05-AUG-2025
DEFINITION  magnesium transporter NIPA2 isoform X1 [Homo sapiens].
ACCESSION   XP_005272603
VERSION     XP_005272603.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005272546.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..360
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..360
                     /product="magnesium transporter NIPA2 isoform X1"
                     /calculated_mol_wt=39054
     Region          8..302
                     /region_name="Mg_trans_NIPA"
                     /note="Magnesium transporter NIPA; pfam05653"
                     /db_xref="CDD:398984"
     CDS             1..360
                     /gene="NIPA2"
                     /gene_synonym="SLC57A2"
                     /coded_by="XM_005272546.4:861..1943"
                     /db_xref="GeneID:81614"
                     /db_xref="HGNC:HGNC:17044"
                     /db_xref="MIM:608146"
ORIGIN      
        1 msqgrgkydf yiglglamss sifiggsfil kkkgllrlar kgsmragqgg haylkewlww
       61 agllsmgage vanfaayafa patlvtplga lsvlvsails syflnerlnl hgkigcllsi
      121 lgstvmviha pkeeeietln emshklgdpg fvvfatlvvi valilifvvg prhgqtnilv
      181 yiticsviga fsvscvkglg iaikelfagk pvlrhplawi lllslivcvs tqinylnral
      241 difntsivtp iyyvffttsv ltcsailfke wqdmpvddvi gtlsgfftii vgifllhafk
      301 dvsfslaslp vsfrkdekam ngnlsnmyev lnnneesltc gieqhtgenv srrngnltaf
//
LOCUS       XP_005272604             360 aa            linear   PRI 05-AUG-2025
DEFINITION  magnesium transporter NIPA2 isoform X1 [Homo sapiens].
ACCESSION   XP_005272604
VERSION     XP_005272604.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005272547.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..360
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..360
                     /product="magnesium transporter NIPA2 isoform X1"
                     /calculated_mol_wt=39054
     Region          8..302
                     /region_name="Mg_trans_NIPA"
                     /note="Magnesium transporter NIPA; pfam05653"
                     /db_xref="CDD:398984"
     CDS             1..360
                     /gene="NIPA2"
                     /gene_synonym="SLC57A2"
                     /coded_by="XM_005272547.5:634..1716"
                     /db_xref="GeneID:81614"
                     /db_xref="HGNC:HGNC:17044"
                     /db_xref="MIM:608146"
ORIGIN      
        1 msqgrgkydf yiglglamss sifiggsfil kkkgllrlar kgsmragqgg haylkewlww
       61 agllsmgage vanfaayafa patlvtplga lsvlvsails syflnerlnl hgkigcllsi
      121 lgstvmviha pkeeeietln emshklgdpg fvvfatlvvi valilifvvg prhgqtnilv
      181 yiticsviga fsvscvkglg iaikelfagk pvlrhplawi lllslivcvs tqinylnral
      241 difntsivtp iyyvffttsv ltcsailfke wqdmpvddvi gtlsgfftii vgifllhafk
      301 dvsfslaslp vsfrkdekam ngnlsnmyev lnnneesltc gieqhtgenv srrngnltaf
//
LOCUS       XP_016878134             360 aa            linear   PRI 05-AUG-2025
DEFINITION  magnesium transporter NIPA2 isoform X1 [Homo sapiens].
ACCESSION   XP_016878134
VERSION     XP_016878134.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022645.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..360
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..360
                     /product="magnesium transporter NIPA2 isoform X1"
                     /calculated_mol_wt=39054
     Region          8..302
                     /region_name="Mg_trans_NIPA"
                     /note="Magnesium transporter NIPA; pfam05653"
                     /db_xref="CDD:398984"
     CDS             1..360
                     /gene="NIPA2"
                     /gene_synonym="SLC57A2"
                     /coded_by="XM_017022645.2:1049..2131"
                     /db_xref="GeneID:81614"
                     /db_xref="HGNC:HGNC:17044"
                     /db_xref="MIM:608146"
ORIGIN      
        1 msqgrgkydf yiglglamss sifiggsfil kkkgllrlar kgsmragqgg haylkewlww
       61 agllsmgage vanfaayafa patlvtplga lsvlvsails syflnerlnl hgkigcllsi
      121 lgstvmviha pkeeeietln emshklgdpg fvvfatlvvi valilifvvg prhgqtnilv
      181 yiticsviga fsvscvkglg iaikelfagk pvlrhplawi lllslivcvs tqinylnral
      241 difntsivtp iyyvffttsv ltcsailfke wqdmpvddvi gtlsgfftii vgifllhafk
      301 dvsfslaslp vsfrkdekam ngnlsnmyev lnnneesltc gieqhtgenv srrngnltaf
//
LOCUS       XP_011542179             360 aa            linear   PRI 05-AUG-2025
DEFINITION  magnesium transporter NIPA2 isoform X1 [Homo sapiens].
ACCESSION   XP_011542179
VERSION     XP_011542179.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011543877.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..360
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..360
                     /product="magnesium transporter NIPA2 isoform X1"
                     /calculated_mol_wt=39054
     Region          8..302
                     /region_name="Mg_trans_NIPA"
                     /note="Magnesium transporter NIPA; pfam05653"
                     /db_xref="CDD:398984"
     CDS             1..360
                     /gene="NIPA2"
                     /gene_synonym="SLC57A2"
                     /coded_by="XM_011543877.3:988..2070"
                     /db_xref="GeneID:81614"
                     /db_xref="HGNC:HGNC:17044"
                     /db_xref="MIM:608146"
ORIGIN      
        1 msqgrgkydf yiglglamss sifiggsfil kkkgllrlar kgsmragqgg haylkewlww
       61 agllsmgage vanfaayafa patlvtplga lsvlvsails syflnerlnl hgkigcllsi
      121 lgstvmviha pkeeeietln emshklgdpg fvvfatlvvi valilifvvg prhgqtnilv
      181 yiticsviga fsvscvkglg iaikelfagk pvlrhplawi lllslivcvs tqinylnral
      241 difntsivtp iyyvffttsv ltcsailfke wqdmpvddvi gtlsgfftii vgifllhafk
      301 dvsfslaslp vsfrkdekam ngnlsnmyev lnnneesltc gieqhtgenv srrngnltaf
//
LOCUS       XP_006720427             360 aa            linear   PRI 05-AUG-2025
DEFINITION  magnesium transporter NIPA2 isoform X1 [Homo sapiens].
ACCESSION   XP_006720427
VERSION     XP_006720427.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720364.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..360
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..360
                     /product="magnesium transporter NIPA2 isoform X1"
                     /calculated_mol_wt=39054
     Region          8..302
                     /region_name="Mg_trans_NIPA"
                     /note="Magnesium transporter NIPA; pfam05653"
                     /db_xref="CDD:398984"
     CDS             1..360
                     /gene="NIPA2"
                     /gene_synonym="SLC57A2"
                     /coded_by="XM_006720364.3:735..1817"
                     /db_xref="GeneID:81614"
                     /db_xref="HGNC:HGNC:17044"
                     /db_xref="MIM:608146"
ORIGIN      
        1 msqgrgkydf yiglglamss sifiggsfil kkkgllrlar kgsmragqgg haylkewlww
       61 agllsmgage vanfaayafa patlvtplga lsvlvsails syflnerlnl hgkigcllsi
      121 lgstvmviha pkeeeietln emshklgdpg fvvfatlvvi valilifvvg prhgqtnilv
      181 yiticsviga fsvscvkglg iaikelfagk pvlrhplawi lllslivcvs tqinylnral
      241 difntsivtp iyyvffttsv ltcsailfke wqdmpvddvi gtlsgfftii vgifllhafk
      301 dvsfslaslp vsfrkdekam ngnlsnmyev lnnneesltc gieqhtgenv srrngnltaf
//
LOCUS       XP_016878135             360 aa            linear   PRI 05-AUG-2025
DEFINITION  magnesium transporter NIPA2 isoform X1 [Homo sapiens].
ACCESSION   XP_016878135
VERSION     XP_016878135.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022646.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..360
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..360
                     /product="magnesium transporter NIPA2 isoform X1"
                     /calculated_mol_wt=39054
     Region          8..302
                     /region_name="Mg_trans_NIPA"
                     /note="Magnesium transporter NIPA; pfam05653"
                     /db_xref="CDD:398984"
     CDS             1..360
                     /gene="NIPA2"
                     /gene_synonym="SLC57A2"
                     /coded_by="XM_017022646.2:796..1878"
                     /db_xref="GeneID:81614"
                     /db_xref="HGNC:HGNC:17044"
                     /db_xref="MIM:608146"
ORIGIN      
        1 msqgrgkydf yiglglamss sifiggsfil kkkgllrlar kgsmragqgg haylkewlww
       61 agllsmgage vanfaayafa patlvtplga lsvlvsails syflnerlnl hgkigcllsi
      121 lgstvmviha pkeeeietln emshklgdpg fvvfatlvvi valilifvvg prhgqtnilv
      181 yiticsviga fsvscvkglg iaikelfagk pvlrhplawi lllslivcvs tqinylnral
      241 difntsivtp iyyvffttsv ltcsailfke wqdmpvddvi gtlsgfftii vgifllhafk
      301 dvsfslaslp vsfrkdekam ngnlsnmyev lnnneesltc gieqhtgenv srrngnltaf
//
LOCUS       XP_016878136             360 aa            linear   PRI 05-AUG-2025
DEFINITION  magnesium transporter NIPA2 isoform X1 [Homo sapiens].
ACCESSION   XP_016878136
VERSION     XP_016878136.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022647.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..360
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..360
                     /product="magnesium transporter NIPA2 isoform X1"
                     /calculated_mol_wt=39054
     Region          8..302
                     /region_name="Mg_trans_NIPA"
                     /note="Magnesium transporter NIPA; pfam05653"
                     /db_xref="CDD:398984"
     CDS             1..360
                     /gene="NIPA2"
                     /gene_synonym="SLC57A2"
                     /coded_by="XM_017022647.2:761..1843"
                     /db_xref="GeneID:81614"
                     /db_xref="HGNC:HGNC:17044"
                     /db_xref="MIM:608146"
ORIGIN      
        1 msqgrgkydf yiglglamss sifiggsfil kkkgllrlar kgsmragqgg haylkewlww
       61 agllsmgage vanfaayafa patlvtplga lsvlvsails syflnerlnl hgkigcllsi
      121 lgstvmviha pkeeeietln emshklgdpg fvvfatlvvi valilifvvg prhgqtnilv
      181 yiticsviga fsvscvkglg iaikelfagk pvlrhplawi lllslivcvs tqinylnral
      241 difntsivtp iyyvffttsv ltcsailfke wqdmpvddvi gtlsgfftii vgifllhafk
      301 dvsfslaslp vsfrkdekam ngnlsnmyev lnnneesltc gieqhtgenv srrngnltaf
//
LOCUS       XP_005272607             360 aa            linear   PRI 05-AUG-2025
DEFINITION  magnesium transporter NIPA2 isoform X1 [Homo sapiens].
ACCESSION   XP_005272607
VERSION     XP_005272607.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005272550.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..360
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..360
                     /product="magnesium transporter NIPA2 isoform X1"
                     /calculated_mol_wt=39054
     Region          8..302
                     /region_name="Mg_trans_NIPA"
                     /note="Magnesium transporter NIPA; pfam05653"
                     /db_xref="CDD:398984"
     CDS             1..360
                     /gene="NIPA2"
                     /gene_synonym="SLC57A2"
                     /coded_by="XM_005272550.4:725..1807"
                     /db_xref="GeneID:81614"
                     /db_xref="HGNC:HGNC:17044"
                     /db_xref="MIM:608146"
ORIGIN      
        1 msqgrgkydf yiglglamss sifiggsfil kkkgllrlar kgsmragqgg haylkewlww
       61 agllsmgage vanfaayafa patlvtplga lsvlvsails syflnerlnl hgkigcllsi
      121 lgstvmviha pkeeeietln emshklgdpg fvvfatlvvi valilifvvg prhgqtnilv
      181 yiticsviga fsvscvkglg iaikelfagk pvlrhplawi lllslivcvs tqinylnral
      241 difntsivtp iyyvffttsv ltcsailfke wqdmpvddvi gtlsgfftii vgifllhafk
      301 dvsfslaslp vsfrkdekam ngnlsnmyev lnnneesltc gieqhtgenv srrngnltaf
//
LOCUS       XP_016878137             360 aa            linear   PRI 05-AUG-2025
DEFINITION  magnesium transporter NIPA2 isoform X1 [Homo sapiens].
ACCESSION   XP_016878137
VERSION     XP_016878137.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022648.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..360
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..360
                     /product="magnesium transporter NIPA2 isoform X1"
                     /calculated_mol_wt=39054
     Region          8..302
                     /region_name="Mg_trans_NIPA"
                     /note="Magnesium transporter NIPA; pfam05653"
                     /db_xref="CDD:398984"
     CDS             1..360
                     /gene="NIPA2"
                     /gene_synonym="SLC57A2"
                     /coded_by="XM_017022648.2:822..1904"
                     /db_xref="GeneID:81614"
                     /db_xref="HGNC:HGNC:17044"
                     /db_xref="MIM:608146"
ORIGIN      
        1 msqgrgkydf yiglglamss sifiggsfil kkkgllrlar kgsmragqgg haylkewlww
       61 agllsmgage vanfaayafa patlvtplga lsvlvsails syflnerlnl hgkigcllsi
      121 lgstvmviha pkeeeietln emshklgdpg fvvfatlvvi valilifvvg prhgqtnilv
      181 yiticsviga fsvscvkglg iaikelfagk pvlrhplawi lllslivcvs tqinylnral
      241 difntsivtp iyyvffttsv ltcsailfke wqdmpvddvi gtlsgfftii vgifllhafk
      301 dvsfslaslp vsfrkdekam ngnlsnmyev lnnneesltc gieqhtgenv srrngnltaf
//
LOCUS       XP_011542182             360 aa            linear   PRI 05-AUG-2025
DEFINITION  magnesium transporter NIPA2 isoform X1 [Homo sapiens].
ACCESSION   XP_011542182
VERSION     XP_011542182.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011543880.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..360
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..360
                     /product="magnesium transporter NIPA2 isoform X1"
                     /calculated_mol_wt=39054
     Region          8..302
                     /region_name="Mg_trans_NIPA"
                     /note="Magnesium transporter NIPA; pfam05653"
                     /db_xref="CDD:398984"
     CDS             1..360
                     /gene="NIPA2"
                     /gene_synonym="SLC57A2"
                     /coded_by="XM_011543880.4:739..1821"
                     /db_xref="GeneID:81614"
                     /db_xref="HGNC:HGNC:17044"
                     /db_xref="MIM:608146"
ORIGIN      
        1 msqgrgkydf yiglglamss sifiggsfil kkkgllrlar kgsmragqgg haylkewlww
       61 agllsmgage vanfaayafa patlvtplga lsvlvsails syflnerlnl hgkigcllsi
      121 lgstvmviha pkeeeietln emshklgdpg fvvfatlvvi valilifvvg prhgqtnilv
      181 yiticsviga fsvscvkglg iaikelfagk pvlrhplawi lllslivcvs tqinylnral
      241 difntsivtp iyyvffttsv ltcsailfke wqdmpvddvi gtlsgfftii vgifllhafk
      301 dvsfslaslp vsfrkdekam ngnlsnmyev lnnneesltc gieqhtgenv srrngnltaf
//
LOCUS       XP_016878138             360 aa            linear   PRI 05-AUG-2025
DEFINITION  magnesium transporter NIPA2 isoform X1 [Homo sapiens].
ACCESSION   XP_016878138
VERSION     XP_016878138.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022649.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..360
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..360
                     /product="magnesium transporter NIPA2 isoform X1"
                     /calculated_mol_wt=39054
     Region          8..302
                     /region_name="Mg_trans_NIPA"
                     /note="Magnesium transporter NIPA; pfam05653"
                     /db_xref="CDD:398984"
     CDS             1..360
                     /gene="NIPA2"
                     /gene_synonym="SLC57A2"
                     /coded_by="XM_017022649.3:959..2041"
                     /db_xref="GeneID:81614"
                     /db_xref="HGNC:HGNC:17044"
                     /db_xref="MIM:608146"
ORIGIN      
        1 msqgrgkydf yiglglamss sifiggsfil kkkgllrlar kgsmragqgg haylkewlww
       61 agllsmgage vanfaayafa patlvtplga lsvlvsails syflnerlnl hgkigcllsi
      121 lgstvmviha pkeeeietln emshklgdpg fvvfatlvvi valilifvvg prhgqtnilv
      181 yiticsviga fsvscvkglg iaikelfagk pvlrhplawi lllslivcvs tqinylnral
      241 difntsivtp iyyvffttsv ltcsailfke wqdmpvddvi gtlsgfftii vgifllhafk
      301 dvsfslaslp vsfrkdekam ngnlsnmyev lnnneesltc gieqhtgenv srrngnltaf
//
LOCUS       XP_011542180             360 aa            linear   PRI 05-AUG-2025
DEFINITION  magnesium transporter NIPA2 isoform X1 [Homo sapiens].
ACCESSION   XP_011542180
VERSION     XP_011542180.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011543878.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..360
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..360
                     /product="magnesium transporter NIPA2 isoform X1"
                     /calculated_mol_wt=39054
     Region          8..302
                     /region_name="Mg_trans_NIPA"
                     /note="Magnesium transporter NIPA; pfam05653"
                     /db_xref="CDD:398984"
     CDS             1..360
                     /gene="NIPA2"
                     /gene_synonym="SLC57A2"
                     /coded_by="XM_011543878.4:1155..2237"
                     /db_xref="GeneID:81614"
                     /db_xref="HGNC:HGNC:17044"
                     /db_xref="MIM:608146"
ORIGIN      
        1 msqgrgkydf yiglglamss sifiggsfil kkkgllrlar kgsmragqgg haylkewlww
       61 agllsmgage vanfaayafa patlvtplga lsvlvsails syflnerlnl hgkigcllsi
      121 lgstvmviha pkeeeietln emshklgdpg fvvfatlvvi valilifvvg prhgqtnilv
      181 yiticsviga fsvscvkglg iaikelfagk pvlrhplawi lllslivcvs tqinylnral
      241 difntsivtp iyyvffttsv ltcsailfke wqdmpvddvi gtlsgfftii vgifllhafk
      301 dvsfslaslp vsfrkdekam ngnlsnmyev lnnneesltc gieqhtgenv srrngnltaf
//
LOCUS       XP_011542181             360 aa            linear   PRI 05-AUG-2025
DEFINITION  magnesium transporter NIPA2 isoform X1 [Homo sapiens].
ACCESSION   XP_011542181
VERSION     XP_011542181.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011543879.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..360
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..360
                     /product="magnesium transporter NIPA2 isoform X1"
                     /calculated_mol_wt=39054
     Region          8..302
                     /region_name="Mg_trans_NIPA"
                     /note="Magnesium transporter NIPA; pfam05653"
                     /db_xref="CDD:398984"
     CDS             1..360
                     /gene="NIPA2"
                     /gene_synonym="SLC57A2"
                     /coded_by="XM_011543879.4:706..1788"
                     /db_xref="GeneID:81614"
                     /db_xref="HGNC:HGNC:17044"
                     /db_xref="MIM:608146"
ORIGIN      
        1 msqgrgkydf yiglglamss sifiggsfil kkkgllrlar kgsmragqgg haylkewlww
       61 agllsmgage vanfaayafa patlvtplga lsvlvsails syflnerlnl hgkigcllsi
      121 lgstvmviha pkeeeietln emshklgdpg fvvfatlvvi valilifvvg prhgqtnilv
      181 yiticsviga fsvscvkglg iaikelfagk pvlrhplawi lllslivcvs tqinylnral
      241 difntsivtp iyyvffttsv ltcsailfke wqdmpvddvi gtlsgfftii vgifllhafk
      301 dvsfslaslp vsfrkdekam ngnlsnmyev lnnneesltc gieqhtgenv srrngnltaf
//
LOCUS       XP_016878139             360 aa            linear   PRI 05-AUG-2025
DEFINITION  magnesium transporter NIPA2 isoform X1 [Homo sapiens].
ACCESSION   XP_016878139
VERSION     XP_016878139.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022650.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..360
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..360
                     /product="magnesium transporter NIPA2 isoform X1"
                     /calculated_mol_wt=39054
     Region          8..302
                     /region_name="Mg_trans_NIPA"
                     /note="Magnesium transporter NIPA; pfam05653"
                     /db_xref="CDD:398984"
     CDS             1..360
                     /gene="NIPA2"
                     /gene_synonym="SLC57A2"
                     /coded_by="XM_017022650.3:902..1984"
                     /db_xref="GeneID:81614"
                     /db_xref="HGNC:HGNC:17044"
                     /db_xref="MIM:608146"
ORIGIN      
        1 msqgrgkydf yiglglamss sifiggsfil kkkgllrlar kgsmragqgg haylkewlww
       61 agllsmgage vanfaayafa patlvtplga lsvlvsails syflnerlnl hgkigcllsi
      121 lgstvmviha pkeeeietln emshklgdpg fvvfatlvvi valilifvvg prhgqtnilv
      181 yiticsviga fsvscvkglg iaikelfagk pvlrhplawi lllslivcvs tqinylnral
      241 difntsivtp iyyvffttsv ltcsailfke wqdmpvddvi gtlsgfftii vgifllhafk
      301 dvsfslaslp vsfrkdekam ngnlsnmyev lnnneesltc gieqhtgenv srrngnltaf
//
LOCUS       XP_047289106             360 aa            linear   PRI 05-AUG-2025
DEFINITION  magnesium transporter NIPA2 isoform X1 [Homo sapiens].
ACCESSION   XP_047289106
VERSION     XP_047289106.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433150.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..360
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..360
                     /product="magnesium transporter NIPA2 isoform X1"
                     /calculated_mol_wt=39054
     Region          8..302
                     /region_name="Mg_trans_NIPA"
                     /note="Magnesium transporter NIPA; pfam05653"
                     /db_xref="CDD:398984"
     CDS             1..360
                     /gene="NIPA2"
                     /gene_synonym="SLC57A2"
                     /coded_by="XM_047433150.1:1086..2168"
                     /db_xref="GeneID:81614"
                     /db_xref="HGNC:HGNC:17044"
                     /db_xref="MIM:608146"
ORIGIN      
        1 msqgrgkydf yiglglamss sifiggsfil kkkgllrlar kgsmragqgg haylkewlww
       61 agllsmgage vanfaayafa patlvtplga lsvlvsails syflnerlnl hgkigcllsi
      121 lgstvmviha pkeeeietln emshklgdpg fvvfatlvvi valilifvvg prhgqtnilv
      181 yiticsviga fsvscvkglg iaikelfagk pvlrhplawi lllslivcvs tqinylnral
      241 difntsivtp iyyvffttsv ltcsailfke wqdmpvddvi gtlsgfftii vgifllhafk
      301 dvsfslaslp vsfrkdekam ngnlsnmyev lnnneesltc gieqhtgenv srrngnltaf
//
LOCUS       XP_016878141             360 aa            linear   PRI 05-AUG-2025
DEFINITION  magnesium transporter NIPA2 isoform X1 [Homo sapiens].
ACCESSION   XP_016878141
VERSION     XP_016878141.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022652.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..360
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..360
                     /product="magnesium transporter NIPA2 isoform X1"
                     /calculated_mol_wt=39054
     Region          8..302
                     /region_name="Mg_trans_NIPA"
                     /note="Magnesium transporter NIPA; pfam05653"
                     /db_xref="CDD:398984"
     CDS             1..360
                     /gene="NIPA2"
                     /gene_synonym="SLC57A2"
                     /coded_by="XM_017022652.3:732..1814"
                     /db_xref="GeneID:81614"
                     /db_xref="HGNC:HGNC:17044"
                     /db_xref="MIM:608146"
ORIGIN      
        1 msqgrgkydf yiglglamss sifiggsfil kkkgllrlar kgsmragqgg haylkewlww
       61 agllsmgage vanfaayafa patlvtplga lsvlvsails syflnerlnl hgkigcllsi
      121 lgstvmviha pkeeeietln emshklgdpg fvvfatlvvi valilifvvg prhgqtnilv
      181 yiticsviga fsvscvkglg iaikelfagk pvlrhplawi lllslivcvs tqinylnral
      241 difntsivtp iyyvffttsv ltcsailfke wqdmpvddvi gtlsgfftii vgifllhafk
      301 dvsfslaslp vsfrkdekam ngnlsnmyev lnnneesltc gieqhtgenv srrngnltaf
//
LOCUS       XP_016878140             360 aa            linear   PRI 05-AUG-2025
DEFINITION  magnesium transporter NIPA2 isoform X1 [Homo sapiens].
ACCESSION   XP_016878140
VERSION     XP_016878140.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022651.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..360
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..360
                     /product="magnesium transporter NIPA2 isoform X1"
                     /calculated_mol_wt=39054
     Region          8..302
                     /region_name="Mg_trans_NIPA"
                     /note="Magnesium transporter NIPA; pfam05653"
                     /db_xref="CDD:398984"
     CDS             1..360
                     /gene="NIPA2"
                     /gene_synonym="SLC57A2"
                     /coded_by="XM_017022651.3:1343..2425"
                     /db_xref="GeneID:81614"
                     /db_xref="HGNC:HGNC:17044"
                     /db_xref="MIM:608146"
ORIGIN      
        1 msqgrgkydf yiglglamss sifiggsfil kkkgllrlar kgsmragqgg haylkewlww
       61 agllsmgage vanfaayafa patlvtplga lsvlvsails syflnerlnl hgkigcllsi
      121 lgstvmviha pkeeeietln emshklgdpg fvvfatlvvi valilifvvg prhgqtnilv
      181 yiticsviga fsvscvkglg iaikelfagk pvlrhplawi lllslivcvs tqinylnral
      241 difntsivtp iyyvffttsv ltcsailfke wqdmpvddvi gtlsgfftii vgifllhafk
      301 dvsfslaslp vsfrkdekam ngnlsnmyev lnnneesltc gieqhtgenv srrngnltaf
//
LOCUS       XP_047289107             360 aa            linear   PRI 05-AUG-2025
DEFINITION  magnesium transporter NIPA2 isoform X1 [Homo sapiens].
ACCESSION   XP_047289107
VERSION     XP_047289107.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433151.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..360
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..360
                     /product="magnesium transporter NIPA2 isoform X1"
                     /calculated_mol_wt=39054
     Region          8..302
                     /region_name="Mg_trans_NIPA"
                     /note="Magnesium transporter NIPA; pfam05653"
                     /db_xref="CDD:398984"
     CDS             1..360
                     /gene="NIPA2"
                     /gene_synonym="SLC57A2"
                     /coded_by="XM_047433151.1:928..2010"
                     /db_xref="GeneID:81614"
                     /db_xref="HGNC:HGNC:17044"
                     /db_xref="MIM:608146"
ORIGIN      
        1 msqgrgkydf yiglglamss sifiggsfil kkkgllrlar kgsmragqgg haylkewlww
       61 agllsmgage vanfaayafa patlvtplga lsvlvsails syflnerlnl hgkigcllsi
      121 lgstvmviha pkeeeietln emshklgdpg fvvfatlvvi valilifvvg prhgqtnilv
      181 yiticsviga fsvscvkglg iaikelfagk pvlrhplawi lllslivcvs tqinylnral
      241 difntsivtp iyyvffttsv ltcsailfke wqdmpvddvi gtlsgfftii vgifllhafk
      301 dvsfslaslp vsfrkdekam ngnlsnmyev lnnneesltc gieqhtgenv srrngnltaf
//
LOCUS       XP_047289108             360 aa            linear   PRI 05-AUG-2025
DEFINITION  magnesium transporter NIPA2 isoform X1 [Homo sapiens].
ACCESSION   XP_047289108
VERSION     XP_047289108.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433152.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..360
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..360
                     /product="magnesium transporter NIPA2 isoform X1"
                     /calculated_mol_wt=39054
     Region          8..302
                     /region_name="Mg_trans_NIPA"
                     /note="Magnesium transporter NIPA; pfam05653"
                     /db_xref="CDD:398984"
     CDS             1..360
                     /gene="NIPA2"
                     /gene_synonym="SLC57A2"
                     /coded_by="XM_047433152.1:1282..2364"
                     /db_xref="GeneID:81614"
                     /db_xref="HGNC:HGNC:17044"
                     /db_xref="MIM:608146"
ORIGIN      
        1 msqgrgkydf yiglglamss sifiggsfil kkkgllrlar kgsmragqgg haylkewlww
       61 agllsmgage vanfaayafa patlvtplga lsvlvsails syflnerlnl hgkigcllsi
      121 lgstvmviha pkeeeietln emshklgdpg fvvfatlvvi valilifvvg prhgqtnilv
      181 yiticsviga fsvscvkglg iaikelfagk pvlrhplawi lllslivcvs tqinylnral
      241 difntsivtp iyyvffttsv ltcsailfke wqdmpvddvi gtlsgfftii vgifllhafk
      301 dvsfslaslp vsfrkdekam ngnlsnmyev lnnneesltc gieqhtgenv srrngnltaf
//
LOCUS       XP_047289109             360 aa            linear   PRI 05-AUG-2025
DEFINITION  magnesium transporter NIPA2 isoform X1 [Homo sapiens].
ACCESSION   XP_047289109
VERSION     XP_047289109.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433153.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..360
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..360
                     /product="magnesium transporter NIPA2 isoform X1"
                     /calculated_mol_wt=39054
     Region          8..302
                     /region_name="Mg_trans_NIPA"
                     /note="Magnesium transporter NIPA; pfam05653"
                     /db_xref="CDD:398984"
     CDS             1..360
                     /gene="NIPA2"
                     /gene_synonym="SLC57A2"
                     /coded_by="XM_047433153.1:512..1594"
                     /db_xref="GeneID:81614"
                     /db_xref="HGNC:HGNC:17044"
                     /db_xref="MIM:608146"
ORIGIN      
        1 msqgrgkydf yiglglamss sifiggsfil kkkgllrlar kgsmragqgg haylkewlww
       61 agllsmgage vanfaayafa patlvtplga lsvlvsails syflnerlnl hgkigcllsi
      121 lgstvmviha pkeeeietln emshklgdpg fvvfatlvvi valilifvvg prhgqtnilv
      181 yiticsviga fsvscvkglg iaikelfagk pvlrhplawi lllslivcvs tqinylnral
      241 difntsivtp iyyvffttsv ltcsailfke wqdmpvddvi gtlsgfftii vgifllhafk
      301 dvsfslaslp vsfrkdekam ngnlsnmyev lnnneesltc gieqhtgenv srrngnltaf
//
LOCUS       XP_047289110             360 aa            linear   PRI 05-AUG-2025
DEFINITION  magnesium transporter NIPA2 isoform X1 [Homo sapiens].
ACCESSION   XP_047289110
VERSION     XP_047289110.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433154.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..360
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..360
                     /product="magnesium transporter NIPA2 isoform X1"
                     /calculated_mol_wt=39054
     Region          8..302
                     /region_name="Mg_trans_NIPA"
                     /note="Magnesium transporter NIPA; pfam05653"
                     /db_xref="CDD:398984"
     CDS             1..360
                     /gene="NIPA2"
                     /gene_synonym="SLC57A2"
                     /coded_by="XM_047433154.1:894..1976"
                     /db_xref="GeneID:81614"
                     /db_xref="HGNC:HGNC:17044"
                     /db_xref="MIM:608146"
ORIGIN      
        1 msqgrgkydf yiglglamss sifiggsfil kkkgllrlar kgsmragqgg haylkewlww
       61 agllsmgage vanfaayafa patlvtplga lsvlvsails syflnerlnl hgkigcllsi
      121 lgstvmviha pkeeeietln emshklgdpg fvvfatlvvi valilifvvg prhgqtnilv
      181 yiticsviga fsvscvkglg iaikelfagk pvlrhplawi lllslivcvs tqinylnral
      241 difntsivtp iyyvffttsv ltcsailfke wqdmpvddvi gtlsgfftii vgifllhafk
      301 dvsfslaslp vsfrkdekam ngnlsnmyev lnnneesltc gieqhtgenv srrngnltaf
//
LOCUS       XP_016878142             360 aa            linear   PRI 05-AUG-2025
DEFINITION  magnesium transporter NIPA2 isoform X1 [Homo sapiens].
ACCESSION   XP_016878142
VERSION     XP_016878142.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022653.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..360
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..360
                     /product="magnesium transporter NIPA2 isoform X1"
                     /calculated_mol_wt=39054
     Region          8..302
                     /region_name="Mg_trans_NIPA"
                     /note="Magnesium transporter NIPA; pfam05653"
                     /db_xref="CDD:398984"
     CDS             1..360
                     /gene="NIPA2"
                     /gene_synonym="SLC57A2"
                     /coded_by="XM_017022653.3:1029..2111"
                     /db_xref="GeneID:81614"
                     /db_xref="HGNC:HGNC:17044"
                     /db_xref="MIM:608146"
ORIGIN      
        1 msqgrgkydf yiglglamss sifiggsfil kkkgllrlar kgsmragqgg haylkewlww
       61 agllsmgage vanfaayafa patlvtplga lsvlvsails syflnerlnl hgkigcllsi
      121 lgstvmviha pkeeeietln emshklgdpg fvvfatlvvi valilifvvg prhgqtnilv
      181 yiticsviga fsvscvkglg iaikelfagk pvlrhplawi lllslivcvs tqinylnral
      241 difntsivtp iyyvffttsv ltcsailfke wqdmpvddvi gtlsgfftii vgifllhafk
      301 dvsfslaslp vsfrkdekam ngnlsnmyev lnnneesltc gieqhtgenv srrngnltaf
//
LOCUS       XP_047289111             360 aa            linear   PRI 05-AUG-2025
DEFINITION  magnesium transporter NIPA2 isoform X1 [Homo sapiens].
ACCESSION   XP_047289111
VERSION     XP_047289111.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433155.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..360
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..360
                     /product="magnesium transporter NIPA2 isoform X1"
                     /calculated_mol_wt=39054
     Region          8..302
                     /region_name="Mg_trans_NIPA"
                     /note="Magnesium transporter NIPA; pfam05653"
                     /db_xref="CDD:398984"
     CDS             1..360
                     /gene="NIPA2"
                     /gene_synonym="SLC57A2"
                     /coded_by="XM_047433155.1:1055..2137"
                     /db_xref="GeneID:81614"
                     /db_xref="HGNC:HGNC:17044"
                     /db_xref="MIM:608146"
ORIGIN      
        1 msqgrgkydf yiglglamss sifiggsfil kkkgllrlar kgsmragqgg haylkewlww
       61 agllsmgage vanfaayafa patlvtplga lsvlvsails syflnerlnl hgkigcllsi
      121 lgstvmviha pkeeeietln emshklgdpg fvvfatlvvi valilifvvg prhgqtnilv
      181 yiticsviga fsvscvkglg iaikelfagk pvlrhplawi lllslivcvs tqinylnral
      241 difntsivtp iyyvffttsv ltcsailfke wqdmpvddvi gtlsgfftii vgifllhafk
      301 dvsfslaslp vsfrkdekam ngnlsnmyev lnnneesltc gieqhtgenv srrngnltaf
//
LOCUS       XP_047289112             360 aa            linear   PRI 05-AUG-2025
DEFINITION  magnesium transporter NIPA2 isoform X1 [Homo sapiens].
ACCESSION   XP_047289112
VERSION     XP_047289112.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433156.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..360
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..360
                     /product="magnesium transporter NIPA2 isoform X1"
                     /calculated_mol_wt=39054
     Region          8..302
                     /region_name="Mg_trans_NIPA"
                     /note="Magnesium transporter NIPA; pfam05653"
                     /db_xref="CDD:398984"
     CDS             1..360
                     /gene="NIPA2"
                     /gene_synonym="SLC57A2"
                     /coded_by="XM_047433156.1:1090..2172"
                     /db_xref="GeneID:81614"
                     /db_xref="HGNC:HGNC:17044"
                     /db_xref="MIM:608146"
ORIGIN      
        1 msqgrgkydf yiglglamss sifiggsfil kkkgllrlar kgsmragqgg haylkewlww
       61 agllsmgage vanfaayafa patlvtplga lsvlvsails syflnerlnl hgkigcllsi
      121 lgstvmviha pkeeeietln emshklgdpg fvvfatlvvi valilifvvg prhgqtnilv
      181 yiticsviga fsvscvkglg iaikelfagk pvlrhplawi lllslivcvs tqinylnral
      241 difntsivtp iyyvffttsv ltcsailfke wqdmpvddvi gtlsgfftii vgifllhafk
      301 dvsfslaslp vsfrkdekam ngnlsnmyev lnnneesltc gieqhtgenv srrngnltaf
//
LOCUS       XP_005272610             360 aa            linear   PRI 05-AUG-2025
DEFINITION  magnesium transporter NIPA2 isoform X1 [Homo sapiens].
ACCESSION   XP_005272610
VERSION     XP_005272610.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005272553.6
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..360
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..360
                     /product="magnesium transporter NIPA2 isoform X1"
                     /calculated_mol_wt=39054
     Region          8..302
                     /region_name="Mg_trans_NIPA"
                     /note="Magnesium transporter NIPA; pfam05653"
                     /db_xref="CDD:398984"
     CDS             1..360
                     /gene="NIPA2"
                     /gene_synonym="SLC57A2"
                     /coded_by="XM_005272553.6:376..1458"
                     /db_xref="GeneID:81614"
                     /db_xref="HGNC:HGNC:17044"
                     /db_xref="MIM:608146"
ORIGIN      
        1 msqgrgkydf yiglglamss sifiggsfil kkkgllrlar kgsmragqgg haylkewlww
       61 agllsmgage vanfaayafa patlvtplga lsvlvsails syflnerlnl hgkigcllsi
      121 lgstvmviha pkeeeietln emshklgdpg fvvfatlvvi valilifvvg prhgqtnilv
      181 yiticsviga fsvscvkglg iaikelfagk pvlrhplawi lllslivcvs tqinylnral
      241 difntsivtp iyyvffttsv ltcsailfke wqdmpvddvi gtlsgfftii vgifllhafk
      301 dvsfslaslp vsfrkdekam ngnlsnmyev lnnneesltc gieqhtgenv srrngnltaf
//
LOCUS       XP_047289113             360 aa            linear   PRI 05-AUG-2025
DEFINITION  magnesium transporter NIPA2 isoform X1 [Homo sapiens].
ACCESSION   XP_047289113
VERSION     XP_047289113.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433157.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..360
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..360
                     /product="magnesium transporter NIPA2 isoform X1"
                     /calculated_mol_wt=39054
     Region          8..302
                     /region_name="Mg_trans_NIPA"
                     /note="Magnesium transporter NIPA; pfam05653"
                     /db_xref="CDD:398984"
     CDS             1..360
                     /gene="NIPA2"
                     /gene_synonym="SLC57A2"
                     /coded_by="XM_047433157.1:615..1697"
                     /db_xref="GeneID:81614"
                     /db_xref="HGNC:HGNC:17044"
                     /db_xref="MIM:608146"
ORIGIN      
        1 msqgrgkydf yiglglamss sifiggsfil kkkgllrlar kgsmragqgg haylkewlww
       61 agllsmgage vanfaayafa patlvtplga lsvlvsails syflnerlnl hgkigcllsi
      121 lgstvmviha pkeeeietln emshklgdpg fvvfatlvvi valilifvvg prhgqtnilv
      181 yiticsviga fsvscvkglg iaikelfagk pvlrhplawi lllslivcvs tqinylnral
      241 difntsivtp iyyvffttsv ltcsailfke wqdmpvddvi gtlsgfftii vgifllhafk
      301 dvsfslaslp vsfrkdekam ngnlsnmyev lnnneesltc gieqhtgenv srrngnltaf
//
LOCUS       XP_016878143             360 aa            linear   PRI 05-AUG-2025
DEFINITION  magnesium transporter NIPA2 isoform X1 [Homo sapiens].
ACCESSION   XP_016878143
VERSION     XP_016878143.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022654.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..360
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..360
                     /product="magnesium transporter NIPA2 isoform X1"
                     /calculated_mol_wt=39054
     Region          8..302
                     /region_name="Mg_trans_NIPA"
                     /note="Magnesium transporter NIPA; pfam05653"
                     /db_xref="CDD:398984"
     CDS             1..360
                     /gene="NIPA2"
                     /gene_synonym="SLC57A2"
                     /coded_by="XM_017022654.3:570..1652"
                     /db_xref="GeneID:81614"
                     /db_xref="HGNC:HGNC:17044"
                     /db_xref="MIM:608146"
ORIGIN      
        1 msqgrgkydf yiglglamss sifiggsfil kkkgllrlar kgsmragqgg haylkewlww
       61 agllsmgage vanfaayafa patlvtplga lsvlvsails syflnerlnl hgkigcllsi
      121 lgstvmviha pkeeeietln emshklgdpg fvvfatlvvi valilifvvg prhgqtnilv
      181 yiticsviga fsvscvkglg iaikelfagk pvlrhplawi lllslivcvs tqinylnral
      241 difntsivtp iyyvffttsv ltcsailfke wqdmpvddvi gtlsgfftii vgifllhafk
      301 dvsfslaslp vsfrkdekam ngnlsnmyev lnnneesltc gieqhtgenv srrngnltaf
//
LOCUS       XP_006720430             341 aa            linear   PRI 05-AUG-2025
DEFINITION  magnesium transporter NIPA2 isoform X2 [Homo sapiens].
ACCESSION   XP_006720430
VERSION     XP_006720430.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720367.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..341
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..341
                     /product="magnesium transporter NIPA2 isoform X2"
                     /calculated_mol_wt=36868
     Region          8..283
                     /region_name="Mg_trans_NIPA"
                     /note="Magnesium transporter NIPA; pfam05653"
                     /db_xref="CDD:398984"
     CDS             1..341
                     /gene="NIPA2"
                     /gene_synonym="SLC57A2"
                     /coded_by="XM_006720367.2:861..1886"
                     /db_xref="GeneID:81614"
                     /db_xref="HGNC:HGNC:17044"
                     /db_xref="MIM:608146"
ORIGIN      
        1 msqgrgkydf yiglglamss sifiggsfil kkkgllrlar kgsmravgag evanfaayaf
       61 apatlvtplg alsvlvsail ssyflnerln lhgkigclls ilgstvmvih apkeeeietl
      121 nemshklgdp gfvvfatlvv ivalilifvv gprhgqtnil vyiticsvig afsvscvkgl
      181 giaikelfag kpvlrhplaw illlslivcv stqinylnra ldifntsivt piyyvfftts
      241 vltcsailfk ewqdmpvddv igtlsgffti ivgifllhaf kdvsfslasl pvsfrkdeka
      301 mngnlsnmye vlnnneeslt cgieqhtgen vsrrngnlta f
//
LOCUS       XP_016878145             341 aa            linear   PRI 05-AUG-2025
DEFINITION  magnesium transporter NIPA2 isoform X2 [Homo sapiens].
ACCESSION   XP_016878145
VERSION     XP_016878145.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022656.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..341
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..341
                     /product="magnesium transporter NIPA2 isoform X2"
                     /calculated_mol_wt=36868
     Region          8..283
                     /region_name="Mg_trans_NIPA"
                     /note="Magnesium transporter NIPA; pfam05653"
                     /db_xref="CDD:398984"
     CDS             1..341
                     /gene="NIPA2"
                     /gene_synonym="SLC57A2"
                     /coded_by="XM_017022656.2:634..1659"
                     /db_xref="GeneID:81614"
                     /db_xref="HGNC:HGNC:17044"
                     /db_xref="MIM:608146"
ORIGIN      
        1 msqgrgkydf yiglglamss sifiggsfil kkkgllrlar kgsmravgag evanfaayaf
       61 apatlvtplg alsvlvsail ssyflnerln lhgkigclls ilgstvmvih apkeeeietl
      121 nemshklgdp gfvvfatlvv ivalilifvv gprhgqtnil vyiticsvig afsvscvkgl
      181 giaikelfag kpvlrhplaw illlslivcv stqinylnra ldifntsivt piyyvfftts
      241 vltcsailfk ewqdmpvddv igtlsgffti ivgifllhaf kdvsfslasl pvsfrkdeka
      301 mngnlsnmye vlnnneeslt cgieqhtgen vsrrngnlta f
//
LOCUS       XP_047289114             341 aa            linear   PRI 05-AUG-2025
DEFINITION  magnesium transporter NIPA2 isoform X2 [Homo sapiens].
ACCESSION   XP_047289114
VERSION     XP_047289114.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433158.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..341
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..341
                     /product="magnesium transporter NIPA2 isoform X2"
                     /calculated_mol_wt=36868
     Region          8..283
                     /region_name="Mg_trans_NIPA"
                     /note="Magnesium transporter NIPA; pfam05653"
                     /db_xref="CDD:398984"
     CDS             1..341
                     /gene="NIPA2"
                     /gene_synonym="SLC57A2"
                     /coded_by="XM_047433158.1:988..2013"
                     /db_xref="GeneID:81614"
                     /db_xref="HGNC:HGNC:17044"
                     /db_xref="MIM:608146"
ORIGIN      
        1 msqgrgkydf yiglglamss sifiggsfil kkkgllrlar kgsmravgag evanfaayaf
       61 apatlvtplg alsvlvsail ssyflnerln lhgkigclls ilgstvmvih apkeeeietl
      121 nemshklgdp gfvvfatlvv ivalilifvv gprhgqtnil vyiticsvig afsvscvkgl
      181 giaikelfag kpvlrhplaw illlslivcv stqinylnra ldifntsivt piyyvfftts
      241 vltcsailfk ewqdmpvddv igtlsgffti ivgifllhaf kdvsfslasl pvsfrkdeka
      301 mngnlsnmye vlnnneeslt cgieqhtgen vsrrngnlta f
//
LOCUS       XP_016878146             341 aa            linear   PRI 05-AUG-2025
DEFINITION  magnesium transporter NIPA2 isoform X2 [Homo sapiens].
ACCESSION   XP_016878146
VERSION     XP_016878146.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022657.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..341
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..341
                     /product="magnesium transporter NIPA2 isoform X2"
                     /calculated_mol_wt=36868
     Region          8..283
                     /region_name="Mg_trans_NIPA"
                     /note="Magnesium transporter NIPA; pfam05653"
                     /db_xref="CDD:398984"
     CDS             1..341
                     /gene="NIPA2"
                     /gene_synonym="SLC57A2"
                     /coded_by="XM_017022657.2:735..1760"
                     /db_xref="GeneID:81614"
                     /db_xref="HGNC:HGNC:17044"
                     /db_xref="MIM:608146"
ORIGIN      
        1 msqgrgkydf yiglglamss sifiggsfil kkkgllrlar kgsmravgag evanfaayaf
       61 apatlvtplg alsvlvsail ssyflnerln lhgkigclls ilgstvmvih apkeeeietl
      121 nemshklgdp gfvvfatlvv ivalilifvv gprhgqtnil vyiticsvig afsvscvkgl
      181 giaikelfag kpvlrhplaw illlslivcv stqinylnra ldifntsivt piyyvfftts
      241 vltcsailfk ewqdmpvddv igtlsgffti ivgifllhaf kdvsfslasl pvsfrkdeka
      301 mngnlsnmye vlnnneeslt cgieqhtgen vsrrngnlta f
//
LOCUS       XP_047289115             341 aa            linear   PRI 05-AUG-2025
DEFINITION  magnesium transporter NIPA2 isoform X2 [Homo sapiens].
ACCESSION   XP_047289115
VERSION     XP_047289115.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433159.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..341
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..341
                     /product="magnesium transporter NIPA2 isoform X2"
                     /calculated_mol_wt=36868
     Region          8..283
                     /region_name="Mg_trans_NIPA"
                     /note="Magnesium transporter NIPA; pfam05653"
                     /db_xref="CDD:398984"
     CDS             1..341
                     /gene="NIPA2"
                     /gene_synonym="SLC57A2"
                     /coded_by="XM_047433159.1:796..1821"
                     /db_xref="GeneID:81614"
                     /db_xref="HGNC:HGNC:17044"
                     /db_xref="MIM:608146"
ORIGIN      
        1 msqgrgkydf yiglglamss sifiggsfil kkkgllrlar kgsmravgag evanfaayaf
       61 apatlvtplg alsvlvsail ssyflnerln lhgkigclls ilgstvmvih apkeeeietl
      121 nemshklgdp gfvvfatlvv ivalilifvv gprhgqtnil vyiticsvig afsvscvkgl
      181 giaikelfag kpvlrhplaw illlslivcv stqinylnra ldifntsivt piyyvfftts
      241 vltcsailfk ewqdmpvddv igtlsgffti ivgifllhaf kdvsfslasl pvsfrkdeka
      301 mngnlsnmye vlnnneeslt cgieqhtgen vsrrngnlta f
//
LOCUS       XP_047289116             341 aa            linear   PRI 05-AUG-2025
DEFINITION  magnesium transporter NIPA2 isoform X2 [Homo sapiens].
ACCESSION   XP_047289116
VERSION     XP_047289116.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433160.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..341
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..341
                     /product="magnesium transporter NIPA2 isoform X2"
                     /calculated_mol_wt=36868
     Region          8..283
                     /region_name="Mg_trans_NIPA"
                     /note="Magnesium transporter NIPA; pfam05653"
                     /db_xref="CDD:398984"
     CDS             1..341
                     /gene="NIPA2"
                     /gene_synonym="SLC57A2"
                     /coded_by="XM_047433160.1:761..1786"
                     /db_xref="GeneID:81614"
                     /db_xref="HGNC:HGNC:17044"
                     /db_xref="MIM:608146"
ORIGIN      
        1 msqgrgkydf yiglglamss sifiggsfil kkkgllrlar kgsmravgag evanfaayaf
       61 apatlvtplg alsvlvsail ssyflnerln lhgkigclls ilgstvmvih apkeeeietl
      121 nemshklgdp gfvvfatlvv ivalilifvv gprhgqtnil vyiticsvig afsvscvkgl
      181 giaikelfag kpvlrhplaw illlslivcv stqinylnra ldifntsivt piyyvfftts
      241 vltcsailfk ewqdmpvddv igtlsgffti ivgifllhaf kdvsfslasl pvsfrkdeka
      301 mngnlsnmye vlnnneeslt cgieqhtgen vsrrngnlta f
//
LOCUS       XP_047289117             341 aa            linear   PRI 05-AUG-2025
DEFINITION  magnesium transporter NIPA2 isoform X2 [Homo sapiens].
ACCESSION   XP_047289117
VERSION     XP_047289117.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433161.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..341
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..341
                     /product="magnesium transporter NIPA2 isoform X2"
                     /calculated_mol_wt=36868
     Region          8..283
                     /region_name="Mg_trans_NIPA"
                     /note="Magnesium transporter NIPA; pfam05653"
                     /db_xref="CDD:398984"
     CDS             1..341
                     /gene="NIPA2"
                     /gene_synonym="SLC57A2"
                     /coded_by="XM_047433161.1:517..1542"
                     /db_xref="GeneID:81614"
                     /db_xref="HGNC:HGNC:17044"
                     /db_xref="MIM:608146"
ORIGIN      
        1 msqgrgkydf yiglglamss sifiggsfil kkkgllrlar kgsmravgag evanfaayaf
       61 apatlvtplg alsvlvsail ssyflnerln lhgkigclls ilgstvmvih apkeeeietl
      121 nemshklgdp gfvvfatlvv ivalilifvv gprhgqtnil vyiticsvig afsvscvkgl
      181 giaikelfag kpvlrhplaw illlslivcv stqinylnra ldifntsivt piyyvfftts
      241 vltcsailfk ewqdmpvddv igtlsgffti ivgifllhaf kdvsfslasl pvsfrkdeka
      301 mngnlsnmye vlnnneeslt cgieqhtgen vsrrngnlta f
//
LOCUS       XP_016878147             341 aa            linear   PRI 05-AUG-2025
DEFINITION  magnesium transporter NIPA2 isoform X2 [Homo sapiens].
ACCESSION   XP_016878147
VERSION     XP_016878147.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022658.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..341
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..341
                     /product="magnesium transporter NIPA2 isoform X2"
                     /calculated_mol_wt=36868
     Region          8..283
                     /region_name="Mg_trans_NIPA"
                     /note="Magnesium transporter NIPA; pfam05653"
                     /db_xref="CDD:398984"
     CDS             1..341
                     /gene="NIPA2"
                     /gene_synonym="SLC57A2"
                     /coded_by="XM_017022658.2:472..1497"
                     /db_xref="GeneID:81614"
                     /db_xref="HGNC:HGNC:17044"
                     /db_xref="MIM:608146"
ORIGIN      
        1 msqgrgkydf yiglglamss sifiggsfil kkkgllrlar kgsmravgag evanfaayaf
       61 apatlvtplg alsvlvsail ssyflnerln lhgkigclls ilgstvmvih apkeeeietl
      121 nemshklgdp gfvvfatlvv ivalilifvv gprhgqtnil vyiticsvig afsvscvkgl
      181 giaikelfag kpvlrhplaw illlslivcv stqinylnra ldifntsivt piyyvfftts
      241 vltcsailfk ewqdmpvddv igtlsgffti ivgifllhaf kdvsfslasl pvsfrkdeka
      301 mngnlsnmye vlnnneeslt cgieqhtgen vsrrngnlta f
//
LOCUS       XP_047289118             341 aa            linear   PRI 05-AUG-2025
DEFINITION  magnesium transporter NIPA2 isoform X2 [Homo sapiens].
ACCESSION   XP_047289118
VERSION     XP_047289118.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433162.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..341
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..341
                     /product="magnesium transporter NIPA2 isoform X2"
                     /calculated_mol_wt=36868
     Region          8..283
                     /region_name="Mg_trans_NIPA"
                     /note="Magnesium transporter NIPA; pfam05653"
                     /db_xref="CDD:398984"
     CDS             1..341
                     /gene="NIPA2"
                     /gene_synonym="SLC57A2"
                     /coded_by="XM_047433162.1:959..1984"
                     /db_xref="GeneID:81614"
                     /db_xref="HGNC:HGNC:17044"
                     /db_xref="MIM:608146"
ORIGIN      
        1 msqgrgkydf yiglglamss sifiggsfil kkkgllrlar kgsmravgag evanfaayaf
       61 apatlvtplg alsvlvsail ssyflnerln lhgkigclls ilgstvmvih apkeeeietl
      121 nemshklgdp gfvvfatlvv ivalilifvv gprhgqtnil vyiticsvig afsvscvkgl
      181 giaikelfag kpvlrhplaw illlslivcv stqinylnra ldifntsivt piyyvfftts
      241 vltcsailfk ewqdmpvddv igtlsgffti ivgifllhaf kdvsfslasl pvsfrkdeka
      301 mngnlsnmye vlnnneeslt cgieqhtgen vsrrngnlta f
//
LOCUS       XP_016878149             341 aa            linear   PRI 05-AUG-2025
DEFINITION  magnesium transporter NIPA2 isoform X2 [Homo sapiens].
ACCESSION   XP_016878149
VERSION     XP_016878149.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022660.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..341
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..341
                     /product="magnesium transporter NIPA2 isoform X2"
                     /calculated_mol_wt=36868
     Region          8..283
                     /region_name="Mg_trans_NIPA"
                     /note="Magnesium transporter NIPA; pfam05653"
                     /db_xref="CDD:398984"
     CDS             1..341
                     /gene="NIPA2"
                     /gene_synonym="SLC57A2"
                     /coded_by="XM_017022660.2:739..1764"
                     /db_xref="GeneID:81614"
                     /db_xref="HGNC:HGNC:17044"
                     /db_xref="MIM:608146"
ORIGIN      
        1 msqgrgkydf yiglglamss sifiggsfil kkkgllrlar kgsmravgag evanfaayaf
       61 apatlvtplg alsvlvsail ssyflnerln lhgkigclls ilgstvmvih apkeeeietl
      121 nemshklgdp gfvvfatlvv ivalilifvv gprhgqtnil vyiticsvig afsvscvkgl
      181 giaikelfag kpvlrhplaw illlslivcv stqinylnra ldifntsivt piyyvfftts
      241 vltcsailfk ewqdmpvddv igtlsgffti ivgifllhaf kdvsfslasl pvsfrkdeka
      301 mngnlsnmye vlnnneeslt cgieqhtgen vsrrngnlta f
//
LOCUS       XP_016878148             341 aa            linear   PRI 05-AUG-2025
DEFINITION  magnesium transporter NIPA2 isoform X2 [Homo sapiens].
ACCESSION   XP_016878148
VERSION     XP_016878148.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022659.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..341
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..341
                     /product="magnesium transporter NIPA2 isoform X2"
                     /calculated_mol_wt=36868
     Region          8..283
                     /region_name="Mg_trans_NIPA"
                     /note="Magnesium transporter NIPA; pfam05653"
                     /db_xref="CDD:398984"
     CDS             1..341
                     /gene="NIPA2"
                     /gene_synonym="SLC57A2"
                     /coded_by="XM_017022659.2:706..1731"
                     /db_xref="GeneID:81614"
                     /db_xref="HGNC:HGNC:17044"
                     /db_xref="MIM:608146"
ORIGIN      
        1 msqgrgkydf yiglglamss sifiggsfil kkkgllrlar kgsmravgag evanfaayaf
       61 apatlvtplg alsvlvsail ssyflnerln lhgkigclls ilgstvmvih apkeeeietl
      121 nemshklgdp gfvvfatlvv ivalilifvv gprhgqtnil vyiticsvig afsvscvkgl
      181 giaikelfag kpvlrhplaw illlslivcv stqinylnra ldifntsivt piyyvfftts
      241 vltcsailfk ewqdmpvddv igtlsgffti ivgifllhaf kdvsfslasl pvsfrkdeka
      301 mngnlsnmye vlnnneeslt cgieqhtgen vsrrngnlta f
//
LOCUS       XP_016878150             341 aa            linear   PRI 05-AUG-2025
DEFINITION  magnesium transporter NIPA2 isoform X2 [Homo sapiens].
ACCESSION   XP_016878150
VERSION     XP_016878150.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022661.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..341
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..341
                     /product="magnesium transporter NIPA2 isoform X2"
                     /calculated_mol_wt=36868
     Region          8..283
                     /region_name="Mg_trans_NIPA"
                     /note="Magnesium transporter NIPA; pfam05653"
                     /db_xref="CDD:398984"
     CDS             1..341
                     /gene="NIPA2"
                     /gene_synonym="SLC57A2"
                     /coded_by="XM_017022661.2:486..1511"
                     /db_xref="GeneID:81614"
                     /db_xref="HGNC:HGNC:17044"
                     /db_xref="MIM:608146"
ORIGIN      
        1 msqgrgkydf yiglglamss sifiggsfil kkkgllrlar kgsmravgag evanfaayaf
       61 apatlvtplg alsvlvsail ssyflnerln lhgkigclls ilgstvmvih apkeeeietl
      121 nemshklgdp gfvvfatlvv ivalilifvv gprhgqtnil vyiticsvig afsvscvkgl
      181 giaikelfag kpvlrhplaw illlslivcv stqinylnra ldifntsivt piyyvfftts
      241 vltcsailfk ewqdmpvddv igtlsgffti ivgifllhaf kdvsfslasl pvsfrkdeka
      301 mngnlsnmye vlnnneeslt cgieqhtgen vsrrngnlta f
//
LOCUS       XP_047289119             341 aa            linear   PRI 05-AUG-2025
DEFINITION  magnesium transporter NIPA2 isoform X2 [Homo sapiens].
ACCESSION   XP_047289119
VERSION     XP_047289119.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433163.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..341
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..341
                     /product="magnesium transporter NIPA2 isoform X2"
                     /calculated_mol_wt=36868
     Region          8..283
                     /region_name="Mg_trans_NIPA"
                     /note="Magnesium transporter NIPA; pfam05653"
                     /db_xref="CDD:398984"
     CDS             1..341
                     /gene="NIPA2"
                     /gene_synonym="SLC57A2"
                     /coded_by="XM_047433163.1:512..1537"
                     /db_xref="GeneID:81614"
                     /db_xref="HGNC:HGNC:17044"
                     /db_xref="MIM:608146"
ORIGIN      
        1 msqgrgkydf yiglglamss sifiggsfil kkkgllrlar kgsmravgag evanfaayaf
       61 apatlvtplg alsvlvsail ssyflnerln lhgkigclls ilgstvmvih apkeeeietl
      121 nemshklgdp gfvvfatlvv ivalilifvv gprhgqtnil vyiticsvig afsvscvkgl
      181 giaikelfag kpvlrhplaw illlslivcv stqinylnra ldifntsivt piyyvfftts
      241 vltcsailfk ewqdmpvddv igtlsgffti ivgifllhaf kdvsfslasl pvsfrkdeka
      301 mngnlsnmye vlnnneeslt cgieqhtgen vsrrngnlta f
//
LOCUS       XP_016878151             341 aa            linear   PRI 05-AUG-2025
DEFINITION  magnesium transporter NIPA2 isoform X2 [Homo sapiens].
ACCESSION   XP_016878151
VERSION     XP_016878151.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022662.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..341
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..341
                     /product="magnesium transporter NIPA2 isoform X2"
                     /calculated_mol_wt=36868
     Region          8..283
                     /region_name="Mg_trans_NIPA"
                     /note="Magnesium transporter NIPA; pfam05653"
                     /db_xref="CDD:398984"
     CDS             1..341
                     /gene="NIPA2"
                     /gene_synonym="SLC57A2"
                     /coded_by="XM_017022662.2:603..1628"
                     /db_xref="GeneID:81614"
                     /db_xref="HGNC:HGNC:17044"
                     /db_xref="MIM:608146"
ORIGIN      
        1 msqgrgkydf yiglglamss sifiggsfil kkkgllrlar kgsmravgag evanfaayaf
       61 apatlvtplg alsvlvsail ssyflnerln lhgkigclls ilgstvmvih apkeeeietl
      121 nemshklgdp gfvvfatlvv ivalilifvv gprhgqtnil vyiticsvig afsvscvkgl
      181 giaikelfag kpvlrhplaw illlslivcv stqinylnra ldifntsivt piyyvfftts
      241 vltcsailfk ewqdmpvddv igtlsgffti ivgifllhaf kdvsfslasl pvsfrkdeka
      301 mngnlsnmye vlnnneeslt cgieqhtgen vsrrngnlta f
//
LOCUS       XP_016878152             341 aa            linear   PRI 05-AUG-2025
DEFINITION  magnesium transporter NIPA2 isoform X2 [Homo sapiens].
ACCESSION   XP_016878152
VERSION     XP_016878152.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022663.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..341
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..341
                     /product="magnesium transporter NIPA2 isoform X2"
                     /calculated_mol_wt=36868
     Region          8..283
                     /region_name="Mg_trans_NIPA"
                     /note="Magnesium transporter NIPA; pfam05653"
                     /db_xref="CDD:398984"
     CDS             1..341
                     /gene="NIPA2"
                     /gene_synonym="SLC57A2"
                     /coded_by="XM_017022663.2:376..1401"
                     /db_xref="GeneID:81614"
                     /db_xref="HGNC:HGNC:17044"
                     /db_xref="MIM:608146"
ORIGIN      
        1 msqgrgkydf yiglglamss sifiggsfil kkkgllrlar kgsmravgag evanfaayaf
       61 apatlvtplg alsvlvsail ssyflnerln lhgkigclls ilgstvmvih apkeeeietl
      121 nemshklgdp gfvvfatlvv ivalilifvv gprhgqtnil vyiticsvig afsvscvkgl
      181 giaikelfag kpvlrhplaw illlslivcv stqinylnra ldifntsivt piyyvfftts
      241 vltcsailfk ewqdmpvddv igtlsgffti ivgifllhaf kdvsfslasl pvsfrkdeka
      301 mngnlsnmye vlnnneeslt cgieqhtgen vsrrngnlta f
//
LOCUS       XP_047289120             375 aa            linear   PRI 05-AUG-2025
DEFINITION  ADP-dependent glucokinase isoform X1 [Homo sapiens].
ACCESSION   XP_047289120
VERSION     XP_047289120.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433164.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..375
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..375
                     /product="ADP-dependent glucokinase isoform X1"
                     /calculated_mol_wt=41028
     Region          1..370
                     /region_name="ADPGK_ADPPFK"
                     /note="ADP-dependent glucokinase (ADPGK) and
                     phosphofructokinase (ADPPFK). ADPGK and ADPPFK are
                     proteins that rely on ADP rather than ATP to donate a
                     phosphoryl group. They are found in certain
                     hyperthermophilic archaea and in higher eukaryotes. A
                     functional...; cd01938"
                     /db_xref="CDD:238913"
     Site            order(37,175,203,206,359)
                     /site_type="other"
                     /note="Mg2+ binding site [ion binding]"
                     /db_xref="CDD:238913"
     Site            order(203,260..261,346,348,351,357..358,361)
                     /site_type="other"
                     /note="ADP binding site [chemical binding]"
                     /db_xref="CDD:238913"
     CDS             1..375
                     /gene="ADPGK"
                     /gene_synonym="2610017G09Rik; ADP-GK"
                     /coded_by="XM_047433164.1:152..1279"
                     /db_xref="GeneID:83440"
                     /db_xref="HGNC:HGNC:25250"
                     /db_xref="MIM:611861"
ORIGIN      
        1 mgkgaaaerf fsdketfhdi aqvasefpga qhyvggnaal igqkfaansd lkvllcgpvg
       61 pklhellddn vfvppeslqe vdefhliley qageewgqlk aphanrfifs hdlsngamnm
      121 levfvsslee fqpdlvvlsg lhmmegqske lqrkrllevv tsisdiptgi pvhlelasmt
      181 nrelmssivh qqvfpavtsl glneqellfl tqsasgphss lsswngvpdv gmvsdilfwi
      241 lkehgrsksr asdltrihfh tlvyhilatv dghwanqlaa vaagarvagt qacatetidt
      301 srvslrapqe fmtshseags rivlnpnkpv vewhregisf hftpvlvckd pirtvglgda
      361 isaeglfyse vhphy
//
LOCUS       XP_011520406             321 aa            linear   PRI 05-AUG-2025
DEFINITION  ADP-dependent glucokinase isoform X2 [Homo sapiens].
ACCESSION   XP_011520406
VERSION     XP_011520406.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522104.4
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 7% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..321
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..321
                     /product="ADP-dependent glucokinase isoform X2"
                     /calculated_mol_wt=34892
     Region          60..>313
                     /region_name="ribokinase_pfkB_like"
                     /note="ribokinase/pfkB superfamily: Kinases that accept a
                     wide variety of substrates, including carbohydrates and
                     aromatic small molecules, all are phosphorylated at a
                     hydroxyl group. The superfamily includes ribokinase,
                     fructokinase, ketohexokinase; cl00192"
                     /db_xref="CDD:469648"
     CDS             1..321
                     /gene="ADPGK"
                     /gene_synonym="2610017G09Rik; ADP-GK"
                     /coded_by="XM_011522104.4:68..1033"
                     /db_xref="GeneID:83440"
                     /db_xref="HGNC:HGNC:25250"
                     /db_xref="MIM:611861"
ORIGIN      
        1 malwrgsaya gflalavgcv fllepelpgs alrslwsslc lgpapappgp vspegrlaaa
       61 wdalivrpvr rwrrvavgvn acvdvvlsgv kllqalglsp gngkdhsilh srndleeafi
      121 hfmgkgaaae rffsdketfh diaqvasefp gaqhyvggna aligqkfaan sdlkvllcgp
      181 vgpklhelld dnvfvppesl qevdefhlil eyqageewgq lkaphanrfi fshdlsngam
      241 nmlevfvssl eefqpdlvvl sglhmmegqs kelqrkrlle vvtsisdipt gipvhlelas
      301 mtnrelmssi vhqwhitkdc i
//
LOCUS       XP_016878153             292 aa            linear   PRI 05-AUG-2025
DEFINITION  ADP-dependent glucokinase isoform X3 [Homo sapiens].
ACCESSION   XP_016878153
VERSION     XP_016878153.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022664.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..292
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..292
                     /product="ADP-dependent glucokinase isoform X3"
                     /calculated_mol_wt=31868
     Region          <27..287
                     /region_name="ribokinase_pfkB_like"
                     /note="ribokinase/pfkB superfamily: Kinases that accept a
                     wide variety of substrates, including carbohydrates and
                     aromatic small molecules, all are phosphorylated at a
                     hydroxyl group. The superfamily includes ribokinase,
                     fructokinase, ketohexokinase; cl00192"
                     /db_xref="CDD:469648"
     Site            order(120,177,271,274..275,278)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:238913"
     CDS             1..292
                     /gene="ADPGK"
                     /gene_synonym="2610017G09Rik; ADP-GK"
                     /coded_by="XM_017022664.3:1..879"
                     /db_xref="GeneID:83440"
                     /db_xref="HGNC:HGNC:25250"
                     /db_xref="MIM:611861"
ORIGIN      
        1 mnttlceerg alttitgrir sicicplhgl sngamnmlev fvssleefqp dlvvlsglhm
       61 megqskelqr krllevvtsi sdiptgipvh lelasmtnre lmssivhqqv fpavtslgln
      121 eqellfltqs asgphsslss wngvpdvgmv sdilfwilke hgrsksrasd ltrihfhtlv
      181 yhilatvdgh wanqlaavaa garvagtqac atetidtsrv slrapqefmt shseagsriv
      241 lnpnkpvvew hregisfhft pvlvckdpir tvglgdaisa eglfysevhp hy
//
LOCUS       XP_011520407             235 aa            linear   PRI 05-AUG-2025
DEFINITION  gamma-secretase subunit APH-1B isoform X1 [Homo sapiens].
ACCESSION   XP_011520407
VERSION     XP_011520407.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522105.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..235
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..235
                     /product="gamma-secretase subunit APH-1B isoform X1"
                     /calculated_mol_wt=25973
     Region          3..>187
                     /region_name="Aph-1"
                     /note="Aph-1 protein; pfam06105"
                     /db_xref="CDD:461830"
     CDS             1..235
                     /gene="APH1B"
                     /gene_synonym="APH-1B; aph-1beta; PRO1328; PSFL; TAAV688"
                     /coded_by="XM_011522105.4:20..727"
                     /db_xref="GeneID:83464"
                     /db_xref="HGNC:HGNC:24080"
                     /db_xref="MIM:607630"
ORIGIN      
        1 mtaavffgca fiafgpalal yvftiatepl riifliagaf fwlvslliss lvwfmarvii
       61 dnkdgptqky llifgafvsv yiqemfrfay ykllkkaseg lksinpgeta psmrllayvs
      121 glgfgimsgv fsfvntlsds lgpgtvgihg dspqfflysa fmtlviillh vfwgivffdg
      181 cekkkwgill ivllthllvs aqvslencsf svtaawkscv fqtrhhdwtl flalv
//
LOCUS       XP_024305853             203 aa            linear   PRI 05-AUG-2025
DEFINITION  gamma-secretase subunit APH-1B isoform X2 [Homo sapiens].
ACCESSION   XP_024305853
VERSION     XP_024305853.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024450085.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..203
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..203
                     /product="gamma-secretase subunit APH-1B isoform X2"
                     /calculated_mol_wt=22399
     Region          <18..178
                     /region_name="Aph-1"
                     /note="Aph-1 protein; pfam06105"
                     /db_xref="CDD:461830"
     CDS             1..203
                     /gene="APH1B"
                     /gene_synonym="APH-1B; aph-1beta; PRO1328; PSFL; TAAV688"
                     /coded_by="XM_024450085.2:74..685"
                     /db_xref="GeneID:83464"
                     /db_xref="HGNC:HGNC:24080"
                     /db_xref="MIM:607630"
ORIGIN      
        1 marviidnkd gptqkyllif gafvsvyiqe mfrfayykll kkaseglksi npgetapsmr
       61 llayvsglgf gimsgvfsfv ntlsdslgpg tvgihgdspq fflysafmtl viillhvfwg
      121 ivffdgcekk kwgillivll thllvsaqtf issyyginla safiilvlmg twaflaaggs
      181 crslklcllc qdknfllynq rsr
//
LOCUS       XP_047289121            1140 aa            linear   PRI 05-AUG-2025
DEFINITION  multiple epidermal growth factor-like domains protein 11 isoform X4
            [Homo sapiens].
ACCESSION   XP_047289121
VERSION     XP_047289121.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433165.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1140
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1140
                     /product="multiple epidermal growth factor-like domains
                     protein 11 isoform X4"
                     /calculated_mol_wt=121288
     Region          25..94
                     /region_name="EMI"
                     /note="EMI domain; pfam07546"
                     /db_xref="CDD:462204"
     Region          275..320
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cl21504"
                     /db_xref="CDD:473889"
     Region          362..409
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cl21504"
                     /db_xref="CDD:473889"
     CDS             1..1140
                     /gene="MEGF11"
                     /coded_by="XM_047433165.1:31..3453"
                     /db_xref="GeneID:84465"
                     /db_xref="HGNC:HGNC:29635"
                     /db_xref="MIM:612454"
ORIGIN      
        1 mvlsltglia fsflqatlal npedpnvcsh wesyavtvqe syahpfdqiy ytrctdilnw
       61 fkctrhrisy ktayrrglrt myrrrsqccp gyyesgdfci plcteecvhg rcvspdtchc
      121 epgwggpdcs sgcdsdhwgp hcsnrcqcqn galcnpitga cvcaagfrgw rceelcapgt
      181 hgkgcqlpcq crhgascdpr ageclcapgy tgvyceelcp pgshgahcel rcpcqnggtc
      241 hhitgecacp pgwtgavcaq pcppgtfgqn csqdcpchhg gqcdhvtgqc hctagymgdr
      301 cqeecpfgsf gfqcsqhcdc hnggqcsptt gacecepgyk gprcqerlcp eglhgpgctl
      361 pcpcdadnti schpvtgact cqpgwsghhc nescpvgyyg dgcqlpctcq ngadchsitg
      421 gctcapgfmg evcavscaag tygpncssic scnnggtcsp vdgsctckeg wqgldctlpc
      481 psgtwglncn esctcangaa cspidgscsc tpgwlgdtce lpcpdgtfgl ncsehcdcsh
      541 adgcdpvtgh ccclagwtgi rcdstcppgr wgpncsvscs cenggscspe dgscecapgf
      601 rgplcqricp pgfyghgcaq pcplcvhssr pchhisgice clpgfsgalc nqvcaggyfg
      661 qdcaqlcsca nngtcspidg scqcfpgwig kdcsqacppg fwgpacfhac schngascsa
      721 edgachctpg wtglfctqrc paaffgkdcg rvcqcqngas cdhisgkctc rtgftgqhce
      781 qrcapgtfgy gcqqlcecmn nstcdhvtgt cycspgfkgi rcdqaalmme elnpytkisp
      841 algaerhsvg avtgimlllf livvllglfa whrrrqkekg rdlaprvsyt pamrmtstdy
      901 slsdlsqsss hahcfsnssy halacggpat sqastldrns ptklsnksld rdtagwtpys
      961 yvnvldshfq isalearypp edfyielrhl srpaephspg acgmdrrqnt yimdkgfkdy
     1021 mkesvcssst cslnssenpy atikdppilt cklpessyve mkspvhmgsp ytdvpslsts
     1081 nkniyevept vsvvqegcgh nssyiqnayd lprnshipgh ydllpvrqsp angpsqdkqs
//
LOCUS       XP_016878159            1097 aa            linear   PRI 05-AUG-2025
DEFINITION  multiple epidermal growth factor-like domains protein 11 isoform X1
            [Homo sapiens].
ACCESSION   XP_016878159
VERSION     XP_016878159.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022670.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1097
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1097
                     /product="multiple epidermal growth factor-like domains
                     protein 11 isoform X1"
                     /calculated_mol_wt=116817
     Region          25..94
                     /region_name="EMI"
                     /note="EMI domain; pfam07546"
                     /db_xref="CDD:462204"
     Region          275..320
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cl21504"
                     /db_xref="CDD:473889"
     Region          362..409
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cl21504"
                     /db_xref="CDD:473889"
     CDS             1..1097
                     /gene="MEGF11"
                     /coded_by="XM_017022670.3:31..3324"
                     /db_xref="GeneID:84465"
                     /db_xref="HGNC:HGNC:29635"
                     /db_xref="MIM:612454"
ORIGIN      
        1 mvlsltglia fsflqatlal npedpnvcsh wesyavtvqe syahpfdqiy ytrctdilnw
       61 fkctrhrisy ktayrrglrt myrrrsqccp gyyesgdfci plcteecvhg rcvspdtchc
      121 epgwggpdcs sgcdsdhwgp hcsnrcqcqn galcnpitga cvcaagfrgw rceelcapgt
      181 hgkgcqlpcq crhgascdpr ageclcapgy tgvyceelcp pgshgahcel rcpcqnggtc
      241 hhitgecacp pgwtgavcaq pcppgtfgqn csqdcpchhg gqcdhvtgqc hctagymgdr
      301 cqeecpfgsf gfqcsqhcdc hnggqcsptt gacecepgyk gprcqerlcp eglhgpgctl
      361 pcpcdadnti schpvtgact cqpgwsghhc nescpvgyyg dgcqlpctcq ngadchsitg
      421 gctcapgfmg evcavscaag tygpncssic scnnggtcsp vdgsctckeg wqgldctlpc
      481 psgtwglncn esctcangaa cspidgscsc tpgwlgdtce lpcpdgtfgl ncsehcdcsh
      541 adgcdpvtgh ccclagwtgi rcdstcppgr wgpncsvscs cenggscspe dgscecapgf
      601 rgplcqricp pgfyghgcaq pcplcvhssr pchhisgice clpgfsgalc nqvcaggyfg
      661 qdcaqlcsca nngtcspidg scqcfpgwig kdcsqgcpaa ffgkdcgrvc qcqngascdh
      721 isgkctcrtg ftgqhceqrc apgtfgygcq qlcecmnnst cdhvtgtcyc spgfkgircd
      781 qaalmmeeln pytkispalg aerhsvgavt gimlllfliv vllglfawhr rrqkekgrdl
      841 aprvsytpam rmtstdysls dlsqssshah cfsnssyhal acggpatsqa stldrnsptk
      901 lsnksldrdt agwtpysyvn vldshfqisa learyppedf yielrhlsrp aephspgacg
      961 mdrrqntyim dkgfkdymke svcssstcsl nssenpyati kdppiltckl pessyvemks
     1021 pvhmgspytd vpslstsnkn iyeveptvsv vqegcghnss yiqnaydlpr nshipghydl
     1081 lpvrqspang psqdkqs
//
LOCUS       XP_016878160            1092 aa            linear   PRI 05-AUG-2025
DEFINITION  multiple epidermal growth factor-like domains protein 11 isoform X2
            [Homo sapiens].
ACCESSION   XP_016878160
VERSION     XP_016878160.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022671.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1092
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1092
                     /product="multiple epidermal growth factor-like domains
                     protein 11 isoform X2"
                     /calculated_mol_wt=116075
     Region          25..94
                     /region_name="EMI"
                     /note="EMI domain; pfam07546"
                     /db_xref="CDD:462204"
     Region          275..320
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cl21504"
                     /db_xref="CDD:473889"
     CDS             1..1092
                     /gene="MEGF11"
                     /coded_by="XM_017022671.3:31..3309"
                     /db_xref="GeneID:84465"
                     /db_xref="HGNC:HGNC:29635"
                     /db_xref="MIM:612454"
ORIGIN      
        1 mvlsltglia fsflqatlal npedpnvcsh wesyavtvqe syahpfdqiy ytrctdilnw
       61 fkctrhrisy ktayrrglrt myrrrsqccp gyyesgdfci plcteecvhg rcvspdtchc
      121 epgwggpdcs sgcdsdhwgp hcsnrcqcqn galcnpitga cvcaagfrgw rceelcapgt
      181 hgkgcqlpcq crhgascdpr ageclcapgy tgvyceelcp pgshgahcel rcpcqnggtc
      241 hhitgecacp pgwtgavcaq pcppgtfgqn csqdcpchhg gqcdhvtgqc hctagymgdr
      301 cqeecpfgsf gfqcsqhcdc hnggqcsptt gacecepgyk gprcqerlcp eglhgpgctl
      361 pcpcdadnti schpvtgact cqpgwsghhc nescpvgyyg dgcqlpctcq ngadchsitg
      421 gctcapgfmg evcavscaag tygpncssic scnnggtcsp vdgsctckeg wqgldctlpc
      481 psgtwglncn esctcangaa cspidgscsc tpgwlgdtce lpcpdgtfgl ncsehcdcsh
      541 adgcdpvtgh ccclagwtgi rcdstcppgr wgpncsvscs cenggscspe dgscecapgf
      601 rgplcqricp pgfyghgcaq pcplcvhssr pchhisgice clpgfsgalc nqvcaggyfg
      661 qdcaqlcsca nngtcspidg scqcfpgwig kdcsqacppg fwgpacfhac schngascsa
      721 edgachctpg wtglfctqrc paaffgkdcg rvcqcqngas cdhisgkctc rtgftgqhce
      781 qrcapgtfgy gcqqlcecmn nstcdhvtgt cycspgfkgi rcdqaalmme elnpytkisp
      841 algaerhsvg avtgimlllf livvllglfa whrrrqkekg rdlaprvsyt pamrmtstdy
      901 slsdlsqsss hahcfsnssy halacggpat sqastldrns ptklsnksld rdtagwtpys
      961 yvnvldshfq isalearypp edfyielrhl srpaephspg acgmdrrqnt yimdkgfkdy
     1021 mkesvcssst cslnssenpy atikdppilt cklpessyve mkspvhmgsp ytdvpslsts
     1081 nkniyevgrc lk
//
LOCUS       XP_047289122            1022 aa            linear   PRI 05-AUG-2025
DEFINITION  multiple epidermal growth factor-like domains protein 11 isoform X3
            [Homo sapiens].
ACCESSION   XP_047289122
VERSION     XP_047289122.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433166.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1022
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1022
                     /product="multiple epidermal growth factor-like domains
                     protein 11 isoform X3"
                     /calculated_mol_wt=108291
     Region          25..94
                     /region_name="EMI"
                     /note="EMI domain; pfam07546"
                     /db_xref="CDD:462204"
     Region          275..320
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cl21504"
                     /db_xref="CDD:473889"
     CDS             1..1022
                     /gene="MEGF11"
                     /coded_by="XM_047433166.1:31..3099"
                     /db_xref="GeneID:84465"
                     /db_xref="HGNC:HGNC:29635"
                     /db_xref="MIM:612454"
ORIGIN      
        1 mvlsltglia fsflqatlal npedpnvcsh wesyavtvqe syahpfdqiy ytrctdilnw
       61 fkctrhrisy ktayrrglrt myrrrsqccp gyyesgdfci plcteecvhg rcvspdtchc
      121 epgwggpdcs sgcdsdhwgp hcsnrcqcqn galcnpitga cvcaagfrgw rceelcapgt
      181 hgkgcqlpcq crhgascdpr ageclcapgy tgvyceelcp pgshgahcel rcpcqnggtc
      241 hhitgecacp pgwtgavcaq pcppgtfgqn csqdcpchhg gqcdhvtgqc hctagymgdr
      301 cqeecpfgsf gfqcsqhcdc hnggqcsptt gacecepgyk gprcqerlcp eglhgpgctl
      361 pcpcdadnti schpvtgact cqpgwsghhc nescpvgyyg dgcqlpctcq ngadchsitg
      421 gctcapgfmg evcavscaag tygpncssic scnnggtcsp vdgsctckeg wqgldctlpc
      481 psgtwglncn esctcangaa cspidgscsc tpgwlgdtce lpcpdgtfgl ncsehcdcsh
      541 adgcdpvtgh ccclagwtgi rcdstcppgr wgpncsvscs cenggscspe dgscecapgf
      601 rgplcqricp pgfyghgcaq pcplcvhssr pchhisgice clpgfsgalc nqvcaggyfg
      661 qdcaqlcsca nngtcspidg scqcfpgwig kdcsqacppg fwgpacfhac schngascsa
      721 edgachctpg wtglfctqrc paaffgkdcg rvcqcqngas cdhisgkctc rtgftgqhce
      781 qrcapgtfgy gcqqlcecmn nstcdhvtgt cycspgfkgi rcdqaalmme elnpytkisp
      841 algaerhsvg avtgimlllf livvllglfa whrrrqkekg rdlaprvsyt pamrmtstdy
      901 slsdlsqsss hahcfsnssy halacggpat sqastldrns ptklsnksld rdtagwtpys
      961 yvnvldshfq isalearypp edfyielrhl srpaephspg acgmdrrqnt yimdkgfkva
     1021 pa
//
LOCUS       XP_016878162            1021 aa            linear   PRI 05-AUG-2025
DEFINITION  multiple epidermal growth factor-like domains protein 11 isoform X4
            [Homo sapiens].
ACCESSION   XP_016878162
VERSION     XP_016878162.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022673.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1021
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1021
                     /product="multiple epidermal growth factor-like domains
                     protein 11 isoform X4"
                     /calculated_mol_wt=108253
     Region          25..94
                     /region_name="EMI"
                     /note="EMI domain; pfam07546"
                     /db_xref="CDD:462204"
     Region          275..320
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cl21504"
                     /db_xref="CDD:473889"
     CDS             1..1021
                     /gene="MEGF11"
                     /coded_by="XM_017022673.3:31..3096"
                     /db_xref="GeneID:84465"
                     /db_xref="HGNC:HGNC:29635"
                     /db_xref="MIM:612454"
ORIGIN      
        1 mvlsltglia fsflqatlal npedpnvcsh wesyavtvqe syahpfdqiy ytrctdilnw
       61 fkctrhrisy ktayrrglrt myrrrsqccp gyyesgdfci plcteecvhg rcvspdtchc
      121 epgwggpdcs sgcdsdhwgp hcsnrcqcqn galcnpitga cvcaagfrgw rceelcapgt
      181 hgkgcqlpcq crhgascdpr ageclcapgy tgvyceelcp pgshgahcel rcpcqnggtc
      241 hhitgecacp pgwtgavcaq pcppgtfgqn csqdcpchhg gqcdhvtgqc hctagymgdr
      301 cqeecpfgsf gfqcsqhcdc hnggqcsptt gacecepgyk gprcqerlcp eglhgpgctl
      361 pcpcdadnti schpvtgact cqpgwsghhc nescpvgyyg dgcqlpctcq ngadchsitg
      421 gctcapgfmg evcavscaag tygpncssic scnnggtcsp vdgsctckeg wqgldctlpc
      481 psgtwglncn esctcangaa cspidgscsc tpgwlgdtce lpcpdgtfgl ncsehcdcsh
      541 adgcdpvtgh ccclagwtgi rcdstcppgr wgpncsvscs cenggscspe dgscecapgf
      601 rgplcqricp pgfyghgcaq pcplcvhssr pchhisgice clpgfsgalc nqvcaggyfg
      661 qdcaqlcsca nngtcspidg scqcfpgwig kdcsqacppg fwgpacfhac schngascsa
      721 edgachctpg wtglfctqrc paaffgkdcg rvcqcqngas cdhisgkctc rtgftgqhce
      781 qrcapgtfgy gcqqlcecmn nstcdhvtgt cycspgfkgi rcdqaalmme elnpytkisp
      841 algaerhsvg avtgimlllf livvllglfa whrrrqkekg rdlaprvsyt pamrmtstdy
      901 slsdlsqsss hahcfsnssy halacggpat sqastldrns ptklsnksld rdtagwtpys
      961 yvnvldshfq isalearypp edfyielrhl srpaephspg acgmdrrqnt yimdkgfkda
     1021 n
//
LOCUS       XP_047289123             979 aa            linear   PRI 05-AUG-2025
DEFINITION  multiple epidermal growth factor-like domains protein 11 isoform X5
            [Homo sapiens].
ACCESSION   XP_047289123
VERSION     XP_047289123.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433167.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..979
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..979
                     /product="multiple epidermal growth factor-like domains
                     protein 11 isoform X5"
                     /calculated_mol_wt=103820
     Region          25..94
                     /region_name="EMI"
                     /note="EMI domain; pfam07546"
                     /db_xref="CDD:462204"
     Region          275..320
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cl21504"
                     /db_xref="CDD:473889"
     CDS             1..979
                     /gene="MEGF11"
                     /coded_by="XM_047433167.1:31..2970"
                     /db_xref="GeneID:84465"
                     /db_xref="HGNC:HGNC:29635"
                     /db_xref="MIM:612454"
ORIGIN      
        1 mvlsltglia fsflqatlal npedpnvcsh wesyavtvqe syahpfdqiy ytrctdilnw
       61 fkctrhrisy ktayrrglrt myrrrsqccp gyyesgdfci plcteecvhg rcvspdtchc
      121 epgwggpdcs sgcdsdhwgp hcsnrcqcqn galcnpitga cvcaagfrgw rceelcapgt
      181 hgkgcqlpcq crhgascdpr ageclcapgy tgvyceelcp pgshgahcel rcpcqnggtc
      241 hhitgecacp pgwtgavcaq pcppgtfgqn csqdcpchhg gqcdhvtgqc hctagymgdr
      301 cqeecpfgsf gfqcsqhcdc hnggqcsptt gacecepgyk gprcqerlcp eglhgpgctl
      361 pcpcdadnti schpvtgact cqpgwsghhc nescpvgyyg dgcqlpctcq ngadchsitg
      421 gctcapgfmg evcavscaag tygpncssic scnnggtcsp vdgsctckeg wqgldctlpc
      481 psgtwglncn esctcangaa cspidgscsc tpgwlgdtce lpcpdgtfgl ncsehcdcsh
      541 adgcdpvtgh ccclagwtgi rcdstcppgr wgpncsvscs cenggscspe dgscecapgf
      601 rgplcqricp pgfyghgcaq pcplcvhssr pchhisgice clpgfsgalc nqvcaggyfg
      661 qdcaqlcsca nngtcspidg scqcfpgwig kdcsqgcpaa ffgkdcgrvc qcqngascdh
      721 isgkctcrtg ftgqhceqrc apgtfgygcq qlcecmnnst cdhvtgtcyc spgfkgircd
      781 qaalmmeeln pytkispalg aerhsvgavt gimlllfliv vllglfawhr rrqkekgrdl
      841 aprvsytpam rmtstdysls dlsqssshah cfsnssyhal acggpatsqa stldrnsptk
      901 lsnksldrdt agwtpysyvn vldshfqisa learyppedf yielrhlsrp aephspgacg
      961 mdrrqntyim dkgfkvapa
//
LOCUS       XP_047289124             964 aa            linear   PRI 05-AUG-2025
DEFINITION  multiple epidermal growth factor-like domains protein 11 isoform X6
            [Homo sapiens].
ACCESSION   XP_047289124
VERSION     XP_047289124.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433168.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..964
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..964
                     /product="multiple epidermal growth factor-like domains
                     protein 11 isoform X6"
                     /calculated_mol_wt=101788
     Region          25..94
                     /region_name="EMI"
                     /note="EMI domain; pfam07546"
                     /db_xref="CDD:462204"
     CDS             1..964
                     /gene="MEGF11"
                     /coded_by="XM_047433168.1:31..2925"
                     /db_xref="GeneID:84465"
                     /db_xref="HGNC:HGNC:29635"
                     /db_xref="MIM:612454"
ORIGIN      
        1 mvlsltglia fsflqatlal npedpnvcsh wesyavtvqe syahpfdqiy ytrctdilnw
       61 fkctrhrisy ktayrrglrt myrrrsqccp gyyesgdfci plcteecvhg rcvspdtchc
      121 epgwggpdcs sgcdsdhwgp hcsnrcqcqn galcnpitga cvcaagfrgw rceelcapgt
      181 hgkgcqlpcq crhgascdpr ageclcapgy tgvyceelcp pgshgahcel rcpcqnggtc
      241 hhitgecacp pgwtgavcaq pcppgtfgqn csqdcpchhg gqcdhvtgqc hctagymgdr
      301 cqeecpfgsf gfqcsqhcdc hnggqcsptt gacecepgyk gprcqerlcp eglhgpgctl
      361 pcpcdadnti schpvtgact cqpgwsghhc nescpvgyyg dgcqlpctcq ngadchsitg
      421 gctcapgfmg evcavscaag tygpncssic scnnggtcsp vdgsctckeg wqgldctlpc
      481 psgtwglncn esctcangaa cspidgscsc tpgwlgdtce lpcpdgtfgl ncsehcdcsh
      541 adgcdpvtgh ccclagwtgi rcdstcppgr wgpncsvscs cenggscspe dgscecapgf
      601 rgplcqricp pgfyghgcaq pcplcvhssr pchhisgice clpgfsgalc nqvcaggyfg
      661 qdcaqlcsca nngtcspidg scqcfpgwig kdcsqacppg fwgpacfhac schngascsa
      721 edgachctpg wtglfctqrc paaffgkdcg rvcqcqngas cdhisgkctc rtgftgqhce
      781 qrcapgtfgy gcqqlcecmn nstcdhvtgt cycspgfkgi rcdqaalmme elnpytkisp
      841 algaerhsvg avtgimlllf livvllglfa whrrrqkekg rdlaprvsyt pamrmtstdy
      901 slsdlsqsss hahcfsnssy halacggpat sqastldrns ptkvlvewid vrthtlwtka
      961 skit
//
LOCUS       XP_047289125             883 aa            linear   PRI 05-AUG-2025
DEFINITION  multiple epidermal growth factor-like domains protein 11 isoform X7
            [Homo sapiens].
ACCESSION   XP_047289125
VERSION     XP_047289125.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433169.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..883
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..883
                     /product="multiple epidermal growth factor-like domains
                     protein 11 isoform X7"
                     /calculated_mol_wt=93245
     Region          25..94
                     /region_name="EMI"
                     /note="EMI domain; pfam07546"
                     /db_xref="CDD:462204"
     CDS             1..883
                     /gene="MEGF11"
                     /coded_by="XM_047433169.1:31..2682"
                     /db_xref="GeneID:84465"
                     /db_xref="HGNC:HGNC:29635"
                     /db_xref="MIM:612454"
ORIGIN      
        1 mvlsltglia fsflqatlal npedpnvcsh wesyavtvqe syahpfdqiy ytrctdilnw
       61 fkctrhrisy ktayrrglrt myrrrsqccp gyyesgdfci plcteecvhg rcvspdtchc
      121 epgwggpdcs sgcdsdhwgp hcsnrcqcqn galcnpitga cvcaagfrgw rceelcapgt
      181 hgkgcqlpcq crhgascdpr ageclcapgy tgvyceelcp pgshgahcel rcpcqnggtc
      241 hhitgecacp pgwtgavcaq pcppgtfgqn csqdcpchhg gqcdhvtgqc hctagymgdr
      301 cqeecpfgsf gfqcsqhcdc hnggqcsptt gacecepgyk gprcqerlcp eglhgpgctl
      361 pcpcdadnti schpvtgact cqpgwsghhc nescpvgyyg dgcqlpctcq ngadchsitg
      421 gctcapgfmg evcavscaag tygpncssic scnnggtcsp vdgsctckeg wqgldctlpc
      481 psgtwglncn esctcangaa cspidgscsc tpgwlgdtce lpcpdgtfgl ncsehcdcsh
      541 adgcdpvtgh ccclagwtgi rcdstcppgr wgpncsvscs cenggscspe dgscecapgf
      601 rgplcqricp pgfyghgcaq pcplcvhssr pchhisgice clpgfsgalc nqvcaggyfg
      661 qdcaqlcsca nngtcspidg scqcfpgwig kdcsqgcpaa ffgkdcgrvc qcqngascdh
      721 isgkctcrtg ftgqhceqrc apgtfgygcq qlcecmnnst cdhvtgtcyc spgfkgircd
      781 qaalmmeeln pytkispalg aerhsvgavt gimlllfliv vllglfawhr rrqkekgrdl
      841 aprvsytpam rmtstdysls gacgmdrrqn tyimdkgfkv apa
//
LOCUS       XP_016878163             854 aa            linear   PRI 05-AUG-2025
DEFINITION  multiple epidermal growth factor-like domains protein 11 isoform X8
            [Homo sapiens].
ACCESSION   XP_016878163
VERSION     XP_016878163.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022674.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..854
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..854
                     /product="multiple epidermal growth factor-like domains
                     protein 11 isoform X8"
                     /calculated_mol_wt=90253
     Region          66..113
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cl21504"
                     /db_xref="CDD:473889"
     CDS             1..854
                     /gene="MEGF11"
                     /coded_by="XM_017022674.3:517..3081"
                     /db_xref="GeneID:84465"
                     /db_xref="HGNC:HGNC:29635"
                     /db_xref="MIM:612454"
ORIGIN      
        1 mgdrcqeecp fgsfgfqcsq hcdchnggqc spttgacece pgykgprcqe rlcpeglhgp
       61 gctlpcpcda dntischpvt gactcqpgws ghhcnescpv gyygdgcqlp ctcqngadch
      121 sitggctcap gfmgevcavs caagtygpnc ssicscnngg tcspvdgsct ckegwqgldc
      181 tlpcpsgtwg lncnesctca ngaacspidg scsctpgwlg dtcelpcpdg tfglncsehc
      241 dcshadgcdp vtghccclag wtgnlpllch hpgircdstc ppgrwgpncs vscscenggs
      301 cspedgscec apgfrgplcq ricppgfygh gcaqpcplcv hssrpchhis giceclpgfs
      361 galcnqvcag gyfgqdcaql cscanngtcs pidgscqcfp gwigkdcsqa cppgfwgpac
      421 fhacschnga scsaedgach ctpgwtglfc tqrcpaaffg kdcgrvcqcq ngascdhisg
      481 kctcrtgftg qhceqrcapg tfgygcqqlc ecmnnstcdh vtgtcycspg fkgircdqaa
      541 lmmeelnpyt kispalgaer hsvgavtgim lllflivvll glfawhrrrq kekgrdlapr
      601 vsytpamrmt stdyslsdls qssshahcfs nssyhalacg gpatsqastl drnsptklsn
      661 ksldrdtagw tpysyvnvld shfqisalea ryppedfyie lrhlsrpaep hspgacgmdr
      721 rqntyimdkg fkdymkesvc ssstcslnss enpyatikdp piltcklpes syvemkspvh
      781 mgspytdvps lstsnkniye veptvsvvqe gcghnssyiq naydlprnsh ipghydllpv
      841 rqspangpsq dkqs
//
LOCUS       XP_016878164             854 aa            linear   PRI 05-AUG-2025
DEFINITION  multiple epidermal growth factor-like domains protein 11 isoform X8
            [Homo sapiens].
ACCESSION   XP_016878164
VERSION     XP_016878164.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022675.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..854
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..854
                     /product="multiple epidermal growth factor-like domains
                     protein 11 isoform X8"
                     /calculated_mol_wt=90253
     Region          66..113
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cl21504"
                     /db_xref="CDD:473889"
     CDS             1..854
                     /gene="MEGF11"
                     /coded_by="XM_017022675.3:189..2753"
                     /db_xref="GeneID:84465"
                     /db_xref="HGNC:HGNC:29635"
                     /db_xref="MIM:612454"
ORIGIN      
        1 mgdrcqeecp fgsfgfqcsq hcdchnggqc spttgacece pgykgprcqe rlcpeglhgp
       61 gctlpcpcda dntischpvt gactcqpgws ghhcnescpv gyygdgcqlp ctcqngadch
      121 sitggctcap gfmgevcavs caagtygpnc ssicscnngg tcspvdgsct ckegwqgldc
      181 tlpcpsgtwg lncnesctca ngaacspidg scsctpgwlg dtcelpcpdg tfglncsehc
      241 dcshadgcdp vtghccclag wtgnlpllch hpgircdstc ppgrwgpncs vscscenggs
      301 cspedgscec apgfrgplcq ricppgfygh gcaqpcplcv hssrpchhis giceclpgfs
      361 galcnqvcag gyfgqdcaql cscanngtcs pidgscqcfp gwigkdcsqa cppgfwgpac
      421 fhacschnga scsaedgach ctpgwtglfc tqrcpaaffg kdcgrvcqcq ngascdhisg
      481 kctcrtgftg qhceqrcapg tfgygcqqlc ecmnnstcdh vtgtcycspg fkgircdqaa
      541 lmmeelnpyt kispalgaer hsvgavtgim lllflivvll glfawhrrrq kekgrdlapr
      601 vsytpamrmt stdyslsdls qssshahcfs nssyhalacg gpatsqastl drnsptklsn
      661 ksldrdtagw tpysyvnvld shfqisalea ryppedfyie lrhlsrpaep hspgacgmdr
      721 rqntyimdkg fkdymkesvc ssstcslnss enpyatikdp piltcklpes syvemkspvh
      781 mgspytdvps lstsnkniye veptvsvvqe gcghnssyiq naydlprnsh ipghydllpv
      841 rqspangpsq dkqs
//
LOCUS       XP_047289126             669 aa            linear   PRI 05-AUG-2025
DEFINITION  multiple epidermal growth factor-like domains protein 11 isoform X9
            [Homo sapiens].
ACCESSION   XP_047289126
VERSION     XP_047289126.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433170.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..669
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..669
                     /product="multiple epidermal growth factor-like domains
                     protein 11 isoform X9"
                     /calculated_mol_wt=70319
     Region          25..94
                     /region_name="EMI"
                     /note="EMI domain; pfam07546"
                     /db_xref="CDD:462204"
     CDS             1..669
                     /gene="MEGF11"
                     /coded_by="XM_047433170.1:31..2040"
                     /db_xref="GeneID:84465"
                     /db_xref="HGNC:HGNC:29635"
                     /db_xref="MIM:612454"
ORIGIN      
        1 mvlsltglia fsflqatlal npedpnvcsh wesyavtvqe syahpfdqiy ytrctdilnw
       61 fkctrhrisy ktayrrglrt myrrrsqccp gyyesgdfci plcteecvhg rcvspdtchc
      121 epgwggpdcs sgcdsdhwgp hcsnrcqcqn galcnpitga cvcaagfrgw rceelcapgt
      181 hgkgcqlpcq crhgascdpr ageclcapgy tgvyceelcp pgshgahcel rcpcqnggtc
      241 hhitgecacp pgwtgavcaq pcppgtfgqn csqdcpchhg gqcdhvtgqc hctagymgdr
      301 cqeecpfgsf gfqcsqhcdc hnggqcsptt gacecepgyk gprcqerlcp eglhgpgctl
      361 pcpcdadnti schpvtgact cqpgwsghhc nescpvgyyg dgcqlpctcq ngadchsitg
      421 gctcapgfmg evcavscaag tygpncssic scnnggtcsp vdgsctckeg wqgldctlpc
      481 psgtwglncn esctcangaa cspidgscsc tpgwlgdtce lpcpdgtfgl ncsehcdcsh
      541 adgcdpvtgh ccclagwtgi rcdstcppgr wgpncsvscs cenggscspe dgscecapgf
      601 rgplcqricp pgfyghgcaq pcplcvhssr pchhisgice clpgfsgalc nqaskwqkqi
      661 liptcmlkg
//
LOCUS       XP_016878165             215 aa            linear   PRI 05-AUG-2025
DEFINITION  CDAN1-interacting nuclease 1 isoform X1 [Homo sapiens].
ACCESSION   XP_016878165
VERSION     XP_016878165.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022676.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..215
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..215
                     /product="CDAN1-interacting nuclease 1 isoform X1"
                     /calculated_mol_wt=24782
     Region          <103..203
                     /region_name="TPD"
                     /note="Protein of unknown function TPD sequence-motif;
                     pfam14811"
                     /db_xref="CDD:464328"
     CDS             1..215
                     /gene="CDIN1"
                     /gene_synonym="C15orf41; HH114"
                     /coded_by="XM_017022676.2:236..883"
                     /db_xref="GeneID:84529"
                     /db_xref="HGNC:HGNC:26929"
                     /db_xref="MIM:615626"
ORIGIN      
        1 miltkaqyde iaqclvsvpp trqslrklkq rfpsqsqatl lsifsqeyqk hikrthakhh
       61 tseaiesyyq rylngvvkng aapvlldlan evdyapslma rlilerflqe heetphedql
      121 rakgydktpd filqvpvave ghiihwiesk asfgdecshh aylhdqfwsy wnrfgpglvi
      181 ywygfiqeld cnrergillk acfptnivtl chsia
//
LOCUS       XP_016878166             215 aa            linear   PRI 05-AUG-2025
DEFINITION  CDAN1-interacting nuclease 1 isoform X1 [Homo sapiens].
ACCESSION   XP_016878166
VERSION     XP_016878166.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022677.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..215
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..215
                     /product="CDAN1-interacting nuclease 1 isoform X1"
                     /calculated_mol_wt=24782
     Region          <103..203
                     /region_name="TPD"
                     /note="Protein of unknown function TPD sequence-motif;
                     pfam14811"
                     /db_xref="CDD:464328"
     CDS             1..215
                     /gene="CDIN1"
                     /gene_synonym="C15orf41; HH114"
                     /coded_by="XM_017022677.2:236..883"
                     /db_xref="GeneID:84529"
                     /db_xref="HGNC:HGNC:26929"
                     /db_xref="MIM:615626"
ORIGIN      
        1 miltkaqyde iaqclvsvpp trqslrklkq rfpsqsqatl lsifsqeyqk hikrthakhh
       61 tseaiesyyq rylngvvkng aapvlldlan evdyapslma rlilerflqe heetphedql
      121 rakgydktpd filqvpvave ghiihwiesk asfgdecshh aylhdqfwsy wnrfgpglvi
      181 ywygfiqeld cnrergillk acfptnivtl chsia
//
LOCUS       XP_047289127             186 aa            linear   PRI 05-AUG-2025
DEFINITION  CDAN1-interacting nuclease 1 isoform X2 [Homo sapiens].
ACCESSION   XP_047289127
VERSION     XP_047289127.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433171.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..186
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..186
                     /product="CDAN1-interacting nuclease 1 isoform X2"
                     /calculated_mol_wt=21014
     Region          132..>158
                     /region_name="TPD"
                     /note="Protein of unknown function TPD sequence-motif;
                     pfam14811"
                     /db_xref="CDD:464328"
     CDS             1..186
                     /gene="CDIN1"
                     /gene_synonym="C15orf41; HH114"
                     /coded_by="XM_047433171.1:236..796"
                     /db_xref="GeneID:84529"
                     /db_xref="HGNC:HGNC:26929"
                     /db_xref="MIM:615626"
ORIGIN      
        1 miltkaqyde iaqclvsvpp trqslrklkq rfpsqsqatl lsifsqeyqk hikrthakhh
       61 tseaiesyyq rylngvvkng aapvlldlan evdyapslma rlilerflqe heetppsksi
      121 insmlrdpsq ipdgvlanqv yqcivndccy gplvdcikqp tytfpttayt hqgknvrnqp
      181 pqlskv
//
LOCUS       XP_047289128             184 aa            linear   PRI 05-AUG-2025
DEFINITION  CDAN1-interacting nuclease 1 isoform X3 [Homo sapiens].
ACCESSION   XP_047289128
VERSION     XP_047289128.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433172.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..184
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..184
                     /product="CDAN1-interacting nuclease 1 isoform X3"
                     /calculated_mol_wt=20762
     Region          132..>159
                     /region_name="TPD"
                     /note="Protein of unknown function TPD sequence-motif;
                     pfam14811"
                     /db_xref="CDD:464328"
     CDS             1..184
                     /gene="CDIN1"
                     /gene_synonym="C15orf41; HH114"
                     /coded_by="XM_047433172.1:236..790"
                     /db_xref="GeneID:84529"
                     /db_xref="HGNC:HGNC:26929"
                     /db_xref="MIM:615626"
ORIGIN      
        1 miltkaqyde iaqclvsvpp trqslrklkq rfpsqsqatl lsifsqeyqk hikrthakhh
       61 tseaiesyyq rylngvvkng aapvlldlan evdyapslma rlilerflqe heetppsksi
      121 insmlrdpsq ipdgvlanqv yqcivndccy gplvdcikhl ysprkkcekp atstfqsvtp
      181 ghsy
//
LOCUS       XP_047289129             184 aa            linear   PRI 05-AUG-2025
DEFINITION  CDAN1-interacting nuclease 1 isoform X3 [Homo sapiens].
ACCESSION   XP_047289129
VERSION     XP_047289129.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433173.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..184
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..184
                     /product="CDAN1-interacting nuclease 1 isoform X3"
                     /calculated_mol_wt=20762
     Region          132..>159
                     /region_name="TPD"
                     /note="Protein of unknown function TPD sequence-motif;
                     pfam14811"
                     /db_xref="CDD:464328"
     CDS             1..184
                     /gene="CDIN1"
                     /gene_synonym="C15orf41; HH114"
                     /coded_by="XM_047433173.1:236..790"
                     /db_xref="GeneID:84529"
                     /db_xref="HGNC:HGNC:26929"
                     /db_xref="MIM:615626"
ORIGIN      
        1 miltkaqyde iaqclvsvpp trqslrklkq rfpsqsqatl lsifsqeyqk hikrthakhh
       61 tseaiesyyq rylngvvkng aapvlldlan evdyapslma rlilerflqe heetppsksi
      121 insmlrdpsq ipdgvlanqv yqcivndccy gplvdcikhl ysprkkcekp atstfqsvtp
      181 ghsy
//
LOCUS       XP_047289130             183 aa            linear   PRI 05-AUG-2025
DEFINITION  CDAN1-interacting nuclease 1 isoform X4 [Homo sapiens].
ACCESSION   XP_047289130
VERSION     XP_047289130.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433174.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 41% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..183
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..183
                     /product="CDAN1-interacting nuclease 1 isoform X4"
                     /calculated_mol_wt=20978
     Region          34..171
                     /region_name="TPD"
                     /note="Protein of unknown function TPD sequence-motif;
                     pfam14811"
                     /db_xref="CDD:464328"
     CDS             1..183
                     /gene="CDIN1"
                     /gene_synonym="C15orf41; HH114"
                     /coded_by="XM_047433174.1:585..1136"
                     /db_xref="GeneID:84529"
                     /db_xref="HGNC:HGNC:26929"
                     /db_xref="MIM:615626"
ORIGIN      
        1 marlilerfl qeheetppsk siinsmlrdp sqipdgvlan qvyqcivndc cygplvdcik
       61 haighehevl lrdllleknl sfldedqlra kgydktpdfi lqvpvavegh iihwieskas
      121 fgdecshhay lhdqfwsywn rfgpglviyw ygfiqeldcn rergillkac fptnivtlch
      181 sia
//
LOCUS       XP_047289131             160 aa            linear   PRI 05-AUG-2025
DEFINITION  CDAN1-interacting nuclease 1 isoform X5 [Homo sapiens].
ACCESSION   XP_047289131
VERSION     XP_047289131.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433175.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..160
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..160
                     /product="CDAN1-interacting nuclease 1 isoform X5"
                     /calculated_mol_wt=18109
     CDS             1..160
                     /gene="CDIN1"
                     /gene_synonym="C15orf41; HH114"
                     /coded_by="XM_047433175.1:236..718"
                     /db_xref="GeneID:84529"
                     /db_xref="HGNC:HGNC:26929"
                     /db_xref="MIM:615626"
ORIGIN      
        1 miltkaqyde iaqclvsvpp trqslrklkq rfpsqsqatl lsifsqeyqk hikrthakhh
       61 tseaiesyyq rylngvvkng aapvlldlan evdyapslma rlilerflqe heetppsksi
      121 insmlrdpsq ipdgvlanqv yqpcpptpfp pqliltkekm
//
LOCUS       XP_047289132             158 aa            linear   PRI 05-AUG-2025
DEFINITION  CDAN1-interacting nuclease 1 isoform X6 [Homo sapiens].
ACCESSION   XP_047289132
VERSION     XP_047289132.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433176.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..158
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..158
                     /product="CDAN1-interacting nuclease 1 isoform X6"
                     /calculated_mol_wt=18057
     Region          9..146
                     /region_name="TPD"
                     /note="Protein of unknown function TPD sequence-motif;
                     pfam14811"
                     /db_xref="CDD:464328"
     CDS             1..158
                     /gene="CDIN1"
                     /gene_synonym="C15orf41; HH114"
                     /coded_by="XM_047433176.1:49..525"
                     /db_xref="GeneID:84529"
                     /db_xref="HGNC:HGNC:26929"
                     /db_xref="MIM:615626"
ORIGIN      
        1 mlrdpsqipd gvlanqvyqc ivndccygpl vdcikhaigh ehevllrdll leknlsflde
       61 dqlrakgydk tpdfilqvpv aveghiihwi eskasfgdec shhaylhdqf wsywnrfgpg
      121 lviywygfiq eldcnrergi llkacfptni vtlchsia
//
LOCUS       XP_047289133             625 aa            linear   PRI 05-AUG-2025
DEFINITION  semaphorin-7A isoform X1 [Homo sapiens].
ACCESSION   XP_047289133
VERSION     XP_047289133.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433177.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..625
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..625
                     /product="semaphorin-7A isoform X1"
                     /calculated_mol_wt=70356
     Region          31..450
                     /region_name="Sema_7A"
                     /note="The Sema domain, a protein interacting module, of
                     semaphorin 7A (Sema7A, also called CD108); cd11243"
                     /db_xref="CDD:200504"
     Site            order(80..83,126..127,131,152,154..155,162,169,172..173,
                     175,180,208,232..235,237,239,334,338,341)
                     /site_type="other"
                     /note="putative plexin binding site [polypeptide binding]"
                     /db_xref="CDD:200504"
     Site            order(209..210,212,215..217,252,255..257,259,261,286..290,
                     347,364)
                     /site_type="other"
                     /note="putative homodimer interface [polypeptide binding]"
                     /db_xref="CDD:200504"
     Region          452..>479
                     /region_name="PSI"
                     /note="Plexin repeat; pfam01437"
                     /db_xref="CDD:396154"
     Region          508..578
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          521..525
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          533..537
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          555..559
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          569..574
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     CDS             1..625
                     /gene="SEMA7A"
                     /gene_synonym="CD108; CDw108; H-SEMA-K1; H-Sema-L; JMH;
                     PFIC11; SEMAK1; SEMAL"
                     /coded_by="XM_047433177.1:435..2312"
                     /db_xref="GeneID:8482"
                     /db_xref="HGNC:HGNC:10741"
                     /db_xref="MIM:607961"
ORIGIN      
        1 mltsggdlam kgcflknegh vgqdrvdfgq tephtvlfhe pgsssvwvgg rgkvylfdfp
       61 egknasvrtv nigstkgscl dkrdcenyit llerrsegll acgtnarhps cwnlvngtvv
      121 plgemrgyap fspdenslvl fegdevysti rkqeyngkip rfrrirgese lytsdtvmqn
      181 pqfikativh qdqayddkiy yffrednpdk npeaplnvsr vaqlcrgdqg gesslsvskw
      241 ntflkamlvc sdaatnknfn rlqdvfllpd psgqwrdtrv ygvfsnpwny savcvyslgd
      301 idkvfrtssl kgyhsslpnp rpgkclpdqq piptetfqva drhpevaqrv epmgplktpl
      361 fhskyhyqkv avhrmqashg etfhvlyltt drgtihkvve pgeqehsfaf nimeiqpfrr
      421 aaaiqtmsld aerrklyvss qwevsqvpld lcevygggch gclmsrdpyc gwdqgrcisi
      481 yssersvlqs inpaephkec pnpkpdkapl qkvslapnsr yylscpmesr hatyswrhke
      541 nveqscepgh qspncilfie nltaqqyghy fceaqegsyf reaqhwqllp edgimaehll
      601 ghacalaasl wlgvlptltl gllvh
//
LOCUS       XP_016878168            1160 aa            linear   PRI 05-AUG-2025
DEFINITION  cartilage intermediate layer protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_016878168
VERSION     XP_016878168.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022679.2
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 3% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1160
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1160
                     /product="cartilage intermediate layer protein 1 isoform
                     X1"
                     /calculated_mol_wt=129783
     Region          32..115
                     /region_name="Mucin2_WxxW"
                     /note="Mucin-2 protein WxxW repeating region; pfam13330"
                     /db_xref="CDD:463846"
     Region          128..176
                     /region_name="TSP1"
                     /note="Thrombospondin type 1 repeats; smart00209"
                     /db_xref="CDD:214559"
     Region          202..>264
                     /region_name="CarboxypepD_reg"
                     /note="Carboxypeptidase regulatory-like domain; pfam13620"
                     /db_xref="CDD:433354"
     Region          285..354
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     CDS             1..1160
                     /gene="CILP"
                     /gene_synonym="CILP-1; CILP1; HsT18872"
                     /coded_by="XM_017022679.2:251..3733"
                     /db_xref="GeneID:8483"
                     /db_xref="HGNC:HGNC:1980"
                     /db_xref="MIM:603489"
ORIGIN      
        1 mltqsvrrvq pgkknpsifa kpadtlespg ewttwfnidy pggkgdyerl dairfyygdr
       61 vcarplrlea rttdwtpags tgqvvhgspr egfwclnreq rpgqncsnyt vrflcppgsl
      121 rrdteriwsp wspwskcsaa cgqtgvqtrt riclaemvsl cseaseegqh cmgqdctacd
      181 ltcpmgqvna dcdacmcqdf mlhgavslpg gapasgaaiy lltktpkllt qtdsdgrfri
      241 pglcpdgksi lkitkvkfap ivltmpktsl kaatikaefv raetpymvmn petkarragq
      301 svslcckatg kprpdkyfwy hndtlldpsl ykhesklvlr klqqhqagey fckaqsdaga
      361 vkskvaqliv iasdetpcnp vpesylirlp hdcfqnatns fyydvgrcpv ktcagqqdng
      421 ircrdavqnc cgiskteere iqcsgytlpt kvakecscqr ctetrsivrg rvsaadngep
      481 mrfghvymgn srvsmtgykg tftlhvpqdt erlvltfvdr lqkfvnttkv lpfnkkgsav
      541 fheikmlrrk kpitleamet niiplgevvg edpmaeleip srsfyrqnge pyigkvkasv
      601 tfldprnist ataaqtdlnf indegdtfpl rtygmfsvdf rdevtsepln agkvkvhlds
      661 tqvkmpehis tvklwslnpd tglweeegdf kfenqrrnkr edrtflvgnl eirerrlfnl
      721 dvpesrrcfv kvrayrserf lpseqiqgvv isvinleprt gflsnprawg rfdsvitgpn
      781 gacvpafcdd qspdaysayv laslageelq avesspkfnp naigvpqpyl nklnyrrtdh
      841 edprvkktaf qismakprpn saeesngpiy afenlracee appsaahfrf yqiegdrydy
      901 ntvpfneddp mswtedylaw wpkpmefrac yikvkivgpl evnvrsrnmg gthrqtvgkl
      961 ygirdvrstr drdqpnvsaa clefkcsgml ydqdrvdrtl vkvipqgscr rasvnpmlhe
     1021 ylvnhlplav nndtseytml apldplghny giytvtdqdp rtakeialgr cfdgtsdgss
     1081 rimksnvgva ltfncverqv grqsafqylq stpaqspaag tvqgrvpsrr qqrasrggqr
     1141 qggvvaslrf prvaqqplin
//
LOCUS       XP_016878169             470 aa            linear   PRI 05-AUG-2025
DEFINITION  signal peptide peptidase-like 2A isoform X2 [Homo sapiens].
ACCESSION   XP_016878169
VERSION     XP_016878169.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022680.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..470
                     /product="signal peptide peptidase-like 2A isoform X2"
                     /calculated_mol_wt=52063
     Region          41..160
                     /region_name="PA_hSPPL_like"
                     /note="Protease-associated domain containing human signal
                     peptide peptidase-like (hSPPL)-like. This group contains
                     various PA domain-containing proteins similar to hSPPL2a
                     and 2b. These SPPLs are GxGD aspartic proteases. SPPL2a is
                     sorted to the late endosomes; cd02129"
                     /db_xref="CDD:239044"
     Site            121..123
                     /site_type="other"
                     /note="PA/protease or protease-like domain interface
                     [polypeptide binding]"
                     /db_xref="CDD:239044"
     Region          210..460
                     /region_name="Peptidase_A22B"
                     /note="Signal peptide peptidase; cl01342"
                     /db_xref="CDD:470165"
     CDS             1..470
                     /gene="SPPL2A"
                     /gene_synonym="IMD86; IMP3; PSL2"
                     /coded_by="XM_017022680.2:174..1586"
                     /db_xref="GeneID:84888"
                     /db_xref="HGNC:HGNC:30227"
                     /db_xref="MIM:608238"
ORIGIN      
        1 mgpqrrlspa gaallwgfll qltaaqeail hasgngttkd ycmlynpywt alpstlenat
       61 sislmnltst plcnlsdipp vgikskavvv pwgschflek ariaqkggae amlvvnnsvl
      121 fppsgnrsef pdvkiliafi sykdfrdmnq tlgdnitvkm yspswpnfdy tmvvifviav
      181 ftvalggyws glvelenlka vttedremrk kkeeyltfsp ltvvifvvic cvmmvllyff
      241 ykwlvyvmia ifciasamsl ynclaalihk ipygqctiac rgknmevrli flsglciava
      301 vvwavfrned rwawilqdil giafclnlik tlklpnfksc villglllly dvffvfitpf
      361 itkngesimv elaagpfgnn ekndgnlvea tgqpsaphek lpvvirvpkl iyfsvmsvcl
      421 mpvsilgfgd iivpglliay crrfdvqtgs syiyyvsstv ddgpfglcnk
//
LOCUS       XP_024305859             614 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat and immunoglobulin-like domain-containing nogo
            receptor-interacting protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_024305859
VERSION     XP_024305859.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024450091.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..614
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..614
                     /product="leucine-rich repeat and immunoglobulin-like
                     domain-containing nogo receptor-interacting protein 1
                     isoform X1"
                     /calculated_mol_wt=69015
     Region          35..69
                     /region_name="LRRNT"
                     /note="Leucine rich repeat N-terminal domain; smart00013"
                     /db_xref="CDD:214470"
     Region          65..>365
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          67..90
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          91..114
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          115..138
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          139..186
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          187..210
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          211..258
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          259..282
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          283..306
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          307..330
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          331..351
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          335..>415
                     /region_name="PCC"
                     /note="polycystin cation channel protein; TIGR00864"
                     /db_xref="CDD:188093"
     Region          417..508
                     /region_name="IgI_Lingo-1"
                     /note="Immunoglobulin I-set domain of the Leucine-rich
                     repeat and immunoglobin-like domain-containing protein 1
                     (Lingo-1); cd20969"
                     /db_xref="CDD:409561"
     Region          417..420
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409561"
     Region          425..429
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409561"
     Region          435..444
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409561"
     Region          449..454
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409561"
     Region          457..459
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409561"
     Region          468..471
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409561"
     Region          474..481
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409561"
     Region          487..495
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409561"
     Region          498..508
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409561"
     CDS             1..614
                     /gene="LINGO1"
                     /gene_synonym="LERN1; LRRN6A; MRT64; UNQ201"
                     /coded_by="XM_024450091.2:524..2368"
                     /db_xref="GeneID:84894"
                     /db_xref="HGNC:HGNC:21205"
                     /db_xref="MIM:609791"
ORIGIN      
        1 mlaggvrsmp spllacwqpi lllvlgsvls gsatgcpprc ecsaqdravl chrkrfvavp
       61 egiptetrll dlgknriktl nqdefasfph leelelneni vsavepgafn nlfnlrtlgl
      121 rsnrlklipl gvftglsnlt kldisenkiv illdymfqdl ynlkslevgd ndlvyishra
      181 fsglnsleql tlekcnltsi ptealshlhg livlrlrhln inairdysfk rlyrlkvlei
      241 shwpyldtmt pnclyglnlt slsithcnlt avpylavrhl vylrflnlsy npistiegsm
      301 lhellrlqei qlvggqlavv epyafrglny lrvlnvsgnq lttleesvfh svgnletlil
      361 dsnplacdcr llwvfrrrwr lnfnrqqptc atpefvqgke fkdfpdvllp nyftcrrari
      421 rdrkaqqvfv deghtvqfvc radgdpppai lwlsprkhlv saksngrltv fpdgtlevry
      481 aqvqdngtyl ciaanaggnd smpahlhvrs yspdwphqpn ktfafisnqp gegeanstra
      541 tvpfpfdikt liiattmgfi sflgvvlfcl vllflwsrgk gntkhnieie yvprksdagi
      601 ssadaprkfn mkmi
//
LOCUS       XP_016878171             614 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat and immunoglobulin-like domain-containing nogo
            receptor-interacting protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_016878171
VERSION     XP_016878171.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022682.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..614
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..614
                     /product="leucine-rich repeat and immunoglobulin-like
                     domain-containing nogo receptor-interacting protein 1
                     isoform X1"
                     /calculated_mol_wt=69015
     Region          35..69
                     /region_name="LRRNT"
                     /note="Leucine rich repeat N-terminal domain; smart00013"
                     /db_xref="CDD:214470"
     Region          65..>365
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          67..90
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          91..114
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          115..138
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          139..186
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          187..210
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          211..258
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          259..282
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          283..306
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          307..330
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          331..351
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          335..>415
                     /region_name="PCC"
                     /note="polycystin cation channel protein; TIGR00864"
                     /db_xref="CDD:188093"
     Region          417..508
                     /region_name="IgI_Lingo-1"
                     /note="Immunoglobulin I-set domain of the Leucine-rich
                     repeat and immunoglobin-like domain-containing protein 1
                     (Lingo-1); cd20969"
                     /db_xref="CDD:409561"
     Region          417..420
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409561"
     Region          425..429
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409561"
     Region          435..444
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409561"
     Region          449..454
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409561"
     Region          457..459
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409561"
     Region          468..471
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409561"
     Region          474..481
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409561"
     Region          487..495
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409561"
     Region          498..508
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409561"
     CDS             1..614
                     /gene="LINGO1"
                     /gene_synonym="LERN1; LRRN6A; MRT64; UNQ201"
                     /coded_by="XM_017022682.2:859..2703"
                     /db_xref="GeneID:84894"
                     /db_xref="HGNC:HGNC:21205"
                     /db_xref="MIM:609791"
ORIGIN      
        1 mlaggvrsmp spllacwqpi lllvlgsvls gsatgcpprc ecsaqdravl chrkrfvavp
       61 egiptetrll dlgknriktl nqdefasfph leelelneni vsavepgafn nlfnlrtlgl
      121 rsnrlklipl gvftglsnlt kldisenkiv illdymfqdl ynlkslevgd ndlvyishra
      181 fsglnsleql tlekcnltsi ptealshlhg livlrlrhln inairdysfk rlyrlkvlei
      241 shwpyldtmt pnclyglnlt slsithcnlt avpylavrhl vylrflnlsy npistiegsm
      301 lhellrlqei qlvggqlavv epyafrglny lrvlnvsgnq lttleesvfh svgnletlil
      361 dsnplacdcr llwvfrrrwr lnfnrqqptc atpefvqgke fkdfpdvllp nyftcrrari
      421 rdrkaqqvfv deghtvqfvc radgdpppai lwlsprkhlv saksngrltv fpdgtlevry
      481 aqvqdngtyl ciaanaggnd smpahlhvrs yspdwphqpn ktfafisnqp gegeanstra
      541 tvpfpfdikt liiattmgfi sflgvvlfcl vllflwsrgk gntkhnieie yvprksdagi
      601 ssadaprkfn mkmi
//
LOCUS       XP_011520420             614 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat and immunoglobulin-like domain-containing nogo
            receptor-interacting protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_011520420
VERSION     XP_011520420.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522118.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..614
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..614
                     /product="leucine-rich repeat and immunoglobulin-like
                     domain-containing nogo receptor-interacting protein 1
                     isoform X1"
                     /calculated_mol_wt=69015
     Region          35..69
                     /region_name="LRRNT"
                     /note="Leucine rich repeat N-terminal domain; smart00013"
                     /db_xref="CDD:214470"
     Region          65..>365
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          67..90
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          91..114
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          115..138
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          139..186
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          187..210
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          211..258
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          259..282
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          283..306
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          307..330
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          331..351
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          335..>415
                     /region_name="PCC"
                     /note="polycystin cation channel protein; TIGR00864"
                     /db_xref="CDD:188093"
     Region          417..508
                     /region_name="IgI_Lingo-1"
                     /note="Immunoglobulin I-set domain of the Leucine-rich
                     repeat and immunoglobin-like domain-containing protein 1
                     (Lingo-1); cd20969"
                     /db_xref="CDD:409561"
     Region          417..420
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409561"
     Region          425..429
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409561"
     Region          435..444
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409561"
     Region          449..454
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409561"
     Region          457..459
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409561"
     Region          468..471
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409561"
     Region          474..481
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409561"
     Region          487..495
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409561"
     Region          498..508
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409561"
     CDS             1..614
                     /gene="LINGO1"
                     /gene_synonym="LERN1; LRRN6A; MRT64; UNQ201"
                     /coded_by="XM_011522118.3:111..1955"
                     /db_xref="GeneID:84894"
                     /db_xref="HGNC:HGNC:21205"
                     /db_xref="MIM:609791"
ORIGIN      
        1 mlaggvrsmp spllacwqpi lllvlgsvls gsatgcpprc ecsaqdravl chrkrfvavp
       61 egiptetrll dlgknriktl nqdefasfph leelelneni vsavepgafn nlfnlrtlgl
      121 rsnrlklipl gvftglsnlt kldisenkiv illdymfqdl ynlkslevgd ndlvyishra
      181 fsglnsleql tlekcnltsi ptealshlhg livlrlrhln inairdysfk rlyrlkvlei
      241 shwpyldtmt pnclyglnlt slsithcnlt avpylavrhl vylrflnlsy npistiegsm
      301 lhellrlqei qlvggqlavv epyafrglny lrvlnvsgnq lttleesvfh svgnletlil
      361 dsnplacdcr llwvfrrrwr lnfnrqqptc atpefvqgke fkdfpdvllp nyftcrrari
      421 rdrkaqqvfv deghtvqfvc radgdpppai lwlsprkhlv saksngrltv fpdgtlevry
      481 aqvqdngtyl ciaanaggnd smpahlhvrs yspdwphqpn ktfafisnqp gegeanstra
      541 tvpfpfdikt liiattmgfi sflgvvlfcl vllflwsrgk gntkhnieie yvprksdagi
      601 ssadaprkfn mkmi
//
LOCUS       XP_024305860             252 aa            linear   PRI 05-AUG-2025
DEFINITION  abscission/NoCut checkpoint regulator isoform X1 [Homo sapiens].
ACCESSION   XP_024305860
VERSION     XP_024305860.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024450092.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..252
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..252
                     /product="abscission/NoCut checkpoint regulator isoform
                     X1"
                     /calculated_mol_wt=27878
     Region          199..243
                     /region_name="Bbox1_ANCHR-like"
                     /note="B-box-type 1 zinc finger found in Abscission/NoCut
                     checkpoint regulator (ANCHR) and similar proteins;
                     cd19817"
                     /db_xref="CDD:380875"
     CDS             1..252
                     /gene="ZFYVE19"
                     /gene_synonym="ANCHR; MPFYVE; PFIC9"
                     /coded_by="XM_024450092.2:96..854"
                     /db_xref="GeneID:84936"
                     /db_xref="HGNC:HGNC:20758"
                     /db_xref="MIM:619635"
ORIGIN      
        1 mearlaalqg rvlpsqtpqp ahhtpdtrtq aqqtqdlltq laaevaides wkgggpaasl
       61 qndlnqggpg stnskrqanw sleeeksrll aeaalelree ntrqerilal akrlamlrgq
      121 dpervtlqdy rlpdsddded eetaiqrvlq qlteeaslde asgfnipaeq asrpwtqprg
      181 aepeaqdvdp rpeaeeeelp wccicnedat lrcagcdgdl fcarcfregh dafelkehqt
      241 saysppragq eh
//
LOCUS       XP_016878173             238 aa            linear   PRI 05-AUG-2025
DEFINITION  abscission/NoCut checkpoint regulator isoform X2 [Homo sapiens].
ACCESSION   XP_016878173
VERSION     XP_016878173.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022684.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..238
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..238
                     /product="abscission/NoCut checkpoint regulator isoform
                     X2"
                     /calculated_mol_wt=25141
     Region          79..129
                     /region_name="FYVE_ZFY19"
                     /note="FYVE-related domain found in FYVE domain-containing
                     protein 19 (ZFY19) and similar proteins; cd15749"
                     /db_xref="CDD:277288"
     CDS             1..238
                     /gene="ZFYVE19"
                     /gene_synonym="ANCHR; MPFYVE; PFIC9"
                     /coded_by="XM_017022684.3:502..1218"
                     /db_xref="GeneID:84936"
                     /db_xref="HGNC:HGNC:20758"
                     /db_xref="MIM:619635"
ORIGIN      
        1 mnydsqqppl pplpyagcrr asgfpalgrg gtvpvgvwgg agqgregrsw gegprgpglg
       61 rrdlssadpa vlgatmesrc ygcavkftlf kkeygckncg rafcsgclsf saavprtgnt
      121 qqkvckqche vltrgssana skwsppqnyk krvaaleakq kpstsqsqgl trqdqmiaer
      181 larlrqenkp rnggttcsva gqsstfsnpp agvgkashpy llilrpatrp gdqgqtar
//
LOCUS       XP_011520422            1303 aa            linear   PRI 05-AUG-2025
DEFINITION  cingulin-like protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_011520422
VERSION     XP_011520422.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522120.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1303
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1303
                     /product="cingulin-like protein 1 isoform X1"
                     /calculated_mol_wt=149036
     Region          <615..1257
                     /region_name="Myosin_tail_1"
                     /note="Myosin tail; pfam01576"
                     /db_xref="CDD:460256"
     CDS             1..1303
                     /gene="CGNL1"
                     /gene_synonym="JACOP; PCING"
                     /coded_by="XM_011522120.2:133..4044"
                     /db_xref="GeneID:84952"
                     /db_xref="HGNC:HGNC:25931"
                     /db_xref="MIM:607856"
ORIGIN      
        1 melyfgeyqh vqqeygvhlr lasddtqksr ssqnskagsy gvsirvqgid ghpyivlnnt
       61 erclagtsfs engppfpppv innlplhssn gsvpkensee lqlpenpyaq pspirnlkqp
      121 llhegkngvl drkdgsvkps hllnfqrhpe llqpydpekn elnlqnhqps esnwlktlte
      181 eginnkkpwt cfpkpsnsqp tspsledpak sgvtairlcs svviedpkkq tsvcvnvqsc
      241 tkervgeeal ftsgrpltah sphahpetkk trpdvlpfrr qdsagpvldg arsrrsssss
      301 ttptsansly rfllddqeca ihadnvnrhe nrryipflpg tgrdidtgsi pgvdqliekf
      361 dqkpglqrrg rsgkrnrint ddrkrsrsvd safpfglqgn seyliefsrn lgkssehllr
      421 psqvcpqrpl sqerrgkqsv grtfaklqga ahgascahsr ppqpnidgkv letegsqest
      481 virapslgaq skkeeevkta tatlmlqnra tatspdsgak kisvktfpsa sntqatpdll
      541 kgqqeltqqt neetakqily nylkegstdn ddatkrkvnl vfekiqtlks raagsaqgnn
      601 qacnstsevk dlleqksklt ievaelqrql qlevknqqni keerermran leelrsqhne
      661 kveenstlqq rleesegelr knleelfqvk mereqhqtei rdlqdqlsem hdeldsakrs
      721 edrekgalie ellqakqdlq dlliakeeqe dllrkrerel talkgalkee vsshdqemdk
      781 lkeqydaelq alresveeat knvevlasrs ntseqdqagt emrvkllqee neklqgrsee
      841 lerrvaqlqr qiedlkgdea kaketlkkye geirqleeal vharkeekea vsarralene
      901 leaaqgnlsq ttqeqkqlse klkeeseqke qlrrlkneme nerwhlgkti eklqkemadi
      961 veasrtstle lqnqldeyke knrrelaemq rqlkektlea eksrltamkm qdemrlmeee
     1021 lrdyqraqde altkrqlleq tlkdleyele akshlkddrs rlvkqmedkv sqlemeleee
     1081 rnnsdllser isrsreqmeq lrnellqera arqdlecdki slerqnkdlk sriihlegsy
     1141 rsskeglvvq meariaeled rleseerdra nlqlsnrrle rkvkelvmqv ddehlsltdq
     1201 kdqlslrlka mkrqveeaee eidrlesskk klqreleeqm dmnehlqgql nsmkkdlsrl
     1261 kklpskvldd mdddddlstd ggslyeapvs ytfskdstva sqi
//
LOCUS       XP_005254783            1303 aa            linear   PRI 05-AUG-2025
DEFINITION  cingulin-like protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_005254783
VERSION     XP_005254783.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254726.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1303
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1303
                     /product="cingulin-like protein 1 isoform X1"
                     /calculated_mol_wt=149036
     Region          <615..1257
                     /region_name="Myosin_tail_1"
                     /note="Myosin tail; pfam01576"
                     /db_xref="CDD:460256"
     CDS             1..1303
                     /gene="CGNL1"
                     /gene_synonym="JACOP; PCING"
                     /coded_by="XM_005254726.5:79..3990"
                     /db_xref="GeneID:84952"
                     /db_xref="HGNC:HGNC:25931"
                     /db_xref="MIM:607856"
ORIGIN      
        1 melyfgeyqh vqqeygvhlr lasddtqksr ssqnskagsy gvsirvqgid ghpyivlnnt
       61 erclagtsfs engppfpppv innlplhssn gsvpkensee lqlpenpyaq pspirnlkqp
      121 llhegkngvl drkdgsvkps hllnfqrhpe llqpydpekn elnlqnhqps esnwlktlte
      181 eginnkkpwt cfpkpsnsqp tspsledpak sgvtairlcs svviedpkkq tsvcvnvqsc
      241 tkervgeeal ftsgrpltah sphahpetkk trpdvlpfrr qdsagpvldg arsrrsssss
      301 ttptsansly rfllddqeca ihadnvnrhe nrryipflpg tgrdidtgsi pgvdqliekf
      361 dqkpglqrrg rsgkrnrint ddrkrsrsvd safpfglqgn seyliefsrn lgkssehllr
      421 psqvcpqrpl sqerrgkqsv grtfaklqga ahgascahsr ppqpnidgkv letegsqest
      481 virapslgaq skkeeevkta tatlmlqnra tatspdsgak kisvktfpsa sntqatpdll
      541 kgqqeltqqt neetakqily nylkegstdn ddatkrkvnl vfekiqtlks raagsaqgnn
      601 qacnstsevk dlleqksklt ievaelqrql qlevknqqni keerermran leelrsqhne
      661 kveenstlqq rleesegelr knleelfqvk mereqhqtei rdlqdqlsem hdeldsakrs
      721 edrekgalie ellqakqdlq dlliakeeqe dllrkrerel talkgalkee vsshdqemdk
      781 lkeqydaelq alresveeat knvevlasrs ntseqdqagt emrvkllqee neklqgrsee
      841 lerrvaqlqr qiedlkgdea kaketlkkye geirqleeal vharkeekea vsarralene
      901 leaaqgnlsq ttqeqkqlse klkeeseqke qlrrlkneme nerwhlgkti eklqkemadi
      961 veasrtstle lqnqldeyke knrrelaemq rqlkektlea eksrltamkm qdemrlmeee
     1021 lrdyqraqde altkrqlleq tlkdleyele akshlkddrs rlvkqmedkv sqlemeleee
     1081 rnnsdllser isrsreqmeq lrnellqera arqdlecdki slerqnkdlk sriihlegsy
     1141 rsskeglvvq meariaeled rleseerdra nlqlsnrrle rkvkelvmqv ddehlsltdq
     1201 kdqlslrlka mkrqveeaee eidrlesskk klqreleeqm dmnehlqgql nsmkkdlsrl
     1261 kklpskvldd mdddddlstd ggslyeapvs ytfskdstva sqi
//
LOCUS       XP_005254784            1303 aa            linear   PRI 05-AUG-2025
DEFINITION  cingulin-like protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_005254784
VERSION     XP_005254784.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254727.6
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1303
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1303
                     /product="cingulin-like protein 1 isoform X1"
                     /calculated_mol_wt=149036
     Region          <615..1257
                     /region_name="Myosin_tail_1"
                     /note="Myosin tail; pfam01576"
                     /db_xref="CDD:460256"
     CDS             1..1303
                     /gene="CGNL1"
                     /gene_synonym="JACOP; PCING"
                     /coded_by="XM_005254727.6:8457..12368"
                     /db_xref="GeneID:84952"
                     /db_xref="HGNC:HGNC:25931"
                     /db_xref="MIM:607856"
ORIGIN      
        1 melyfgeyqh vqqeygvhlr lasddtqksr ssqnskagsy gvsirvqgid ghpyivlnnt
       61 erclagtsfs engppfpppv innlplhssn gsvpkensee lqlpenpyaq pspirnlkqp
      121 llhegkngvl drkdgsvkps hllnfqrhpe llqpydpekn elnlqnhqps esnwlktlte
      181 eginnkkpwt cfpkpsnsqp tspsledpak sgvtairlcs svviedpkkq tsvcvnvqsc
      241 tkervgeeal ftsgrpltah sphahpetkk trpdvlpfrr qdsagpvldg arsrrsssss
      301 ttptsansly rfllddqeca ihadnvnrhe nrryipflpg tgrdidtgsi pgvdqliekf
      361 dqkpglqrrg rsgkrnrint ddrkrsrsvd safpfglqgn seyliefsrn lgkssehllr
      421 psqvcpqrpl sqerrgkqsv grtfaklqga ahgascahsr ppqpnidgkv letegsqest
      481 virapslgaq skkeeevkta tatlmlqnra tatspdsgak kisvktfpsa sntqatpdll
      541 kgqqeltqqt neetakqily nylkegstdn ddatkrkvnl vfekiqtlks raagsaqgnn
      601 qacnstsevk dlleqksklt ievaelqrql qlevknqqni keerermran leelrsqhne
      661 kveenstlqq rleesegelr knleelfqvk mereqhqtei rdlqdqlsem hdeldsakrs
      721 edrekgalie ellqakqdlq dlliakeeqe dllrkrerel talkgalkee vsshdqemdk
      781 lkeqydaelq alresveeat knvevlasrs ntseqdqagt emrvkllqee neklqgrsee
      841 lerrvaqlqr qiedlkgdea kaketlkkye geirqleeal vharkeekea vsarralene
      901 leaaqgnlsq ttqeqkqlse klkeeseqke qlrrlkneme nerwhlgkti eklqkemadi
      961 veasrtstle lqnqldeyke knrrelaemq rqlkektlea eksrltamkm qdemrlmeee
     1021 lrdyqraqde altkrqlleq tlkdleyele akshlkddrs rlvkqmedkv sqlemeleee
     1081 rnnsdllser isrsreqmeq lrnellqera arqdlecdki slerqnkdlk sriihlegsy
     1141 rsskeglvvq meariaeled rleseerdra nlqlsnrrle rkvkelvmqv ddehlsltdq
     1201 kdqlslrlka mkrqveeaee eidrlesskk klqreleeqm dmnehlqgql nsmkkdlsrl
     1261 kklpskvldd mdddddlstd ggslyeapvs ytfskdstva sqi
//
LOCUS       XP_047289134            1303 aa            linear   PRI 05-AUG-2025
DEFINITION  cingulin-like protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047289134
VERSION     XP_047289134.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433178.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1303
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1303
                     /product="cingulin-like protein 1 isoform X1"
                     /calculated_mol_wt=149036
     Region          <615..1257
                     /region_name="Myosin_tail_1"
                     /note="Myosin tail; pfam01576"
                     /db_xref="CDD:460256"
     CDS             1..1303
                     /gene="CGNL1"
                     /gene_synonym="JACOP; PCING"
                     /coded_by="XM_047433178.1:194..4105"
                     /db_xref="GeneID:84952"
                     /db_xref="HGNC:HGNC:25931"
                     /db_xref="MIM:607856"
ORIGIN      
        1 melyfgeyqh vqqeygvhlr lasddtqksr ssqnskagsy gvsirvqgid ghpyivlnnt
       61 erclagtsfs engppfpppv innlplhssn gsvpkensee lqlpenpyaq pspirnlkqp
      121 llhegkngvl drkdgsvkps hllnfqrhpe llqpydpekn elnlqnhqps esnwlktlte
      181 eginnkkpwt cfpkpsnsqp tspsledpak sgvtairlcs svviedpkkq tsvcvnvqsc
      241 tkervgeeal ftsgrpltah sphahpetkk trpdvlpfrr qdsagpvldg arsrrsssss
      301 ttptsansly rfllddqeca ihadnvnrhe nrryipflpg tgrdidtgsi pgvdqliekf
      361 dqkpglqrrg rsgkrnrint ddrkrsrsvd safpfglqgn seyliefsrn lgkssehllr
      421 psqvcpqrpl sqerrgkqsv grtfaklqga ahgascahsr ppqpnidgkv letegsqest
      481 virapslgaq skkeeevkta tatlmlqnra tatspdsgak kisvktfpsa sntqatpdll
      541 kgqqeltqqt neetakqily nylkegstdn ddatkrkvnl vfekiqtlks raagsaqgnn
      601 qacnstsevk dlleqksklt ievaelqrql qlevknqqni keerermran leelrsqhne
      661 kveenstlqq rleesegelr knleelfqvk mereqhqtei rdlqdqlsem hdeldsakrs
      721 edrekgalie ellqakqdlq dlliakeeqe dllrkrerel talkgalkee vsshdqemdk
      781 lkeqydaelq alresveeat knvevlasrs ntseqdqagt emrvkllqee neklqgrsee
      841 lerrvaqlqr qiedlkgdea kaketlkkye geirqleeal vharkeekea vsarralene
      901 leaaqgnlsq ttqeqkqlse klkeeseqke qlrrlkneme nerwhlgkti eklqkemadi
      961 veasrtstle lqnqldeyke knrrelaemq rqlkektlea eksrltamkm qdemrlmeee
     1021 lrdyqraqde altkrqlleq tlkdleyele akshlkddrs rlvkqmedkv sqlemeleee
     1081 rnnsdllser isrsreqmeq lrnellqera arqdlecdki slerqnkdlk sriihlegsy
     1141 rsskeglvvq meariaeled rleseerdra nlqlsnrrle rkvkelvmqv ddehlsltdq
     1201 kdqlslrlka mkrqveeaee eidrlesskk klqreleeqm dmnehlqgql nsmkkdlsrl
     1261 kklpskvldd mdddddlstd ggslyeapvs ytfskdstva sqi
//
LOCUS       XP_047289135            1303 aa            linear   PRI 05-AUG-2025
DEFINITION  cingulin-like protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047289135
VERSION     XP_047289135.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433179.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1303
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1303
                     /product="cingulin-like protein 1 isoform X1"
                     /calculated_mol_wt=149036
     Region          <615..1257
                     /region_name="Myosin_tail_1"
                     /note="Myosin tail; pfam01576"
                     /db_xref="CDD:460256"
     CDS             1..1303
                     /gene="CGNL1"
                     /gene_synonym="JACOP; PCING"
                     /coded_by="XM_047433179.1:545..4456"
                     /db_xref="GeneID:84952"
                     /db_xref="HGNC:HGNC:25931"
                     /db_xref="MIM:607856"
ORIGIN      
        1 melyfgeyqh vqqeygvhlr lasddtqksr ssqnskagsy gvsirvqgid ghpyivlnnt
       61 erclagtsfs engppfpppv innlplhssn gsvpkensee lqlpenpyaq pspirnlkqp
      121 llhegkngvl drkdgsvkps hllnfqrhpe llqpydpekn elnlqnhqps esnwlktlte
      181 eginnkkpwt cfpkpsnsqp tspsledpak sgvtairlcs svviedpkkq tsvcvnvqsc
      241 tkervgeeal ftsgrpltah sphahpetkk trpdvlpfrr qdsagpvldg arsrrsssss
      301 ttptsansly rfllddqeca ihadnvnrhe nrryipflpg tgrdidtgsi pgvdqliekf
      361 dqkpglqrrg rsgkrnrint ddrkrsrsvd safpfglqgn seyliefsrn lgkssehllr
      421 psqvcpqrpl sqerrgkqsv grtfaklqga ahgascahsr ppqpnidgkv letegsqest
      481 virapslgaq skkeeevkta tatlmlqnra tatspdsgak kisvktfpsa sntqatpdll
      541 kgqqeltqqt neetakqily nylkegstdn ddatkrkvnl vfekiqtlks raagsaqgnn
      601 qacnstsevk dlleqksklt ievaelqrql qlevknqqni keerermran leelrsqhne
      661 kveenstlqq rleesegelr knleelfqvk mereqhqtei rdlqdqlsem hdeldsakrs
      721 edrekgalie ellqakqdlq dlliakeeqe dllrkrerel talkgalkee vsshdqemdk
      781 lkeqydaelq alresveeat knvevlasrs ntseqdqagt emrvkllqee neklqgrsee
      841 lerrvaqlqr qiedlkgdea kaketlkkye geirqleeal vharkeekea vsarralene
      901 leaaqgnlsq ttqeqkqlse klkeeseqke qlrrlkneme nerwhlgkti eklqkemadi
      961 veasrtstle lqnqldeyke knrrelaemq rqlkektlea eksrltamkm qdemrlmeee
     1021 lrdyqraqde altkrqlleq tlkdleyele akshlkddrs rlvkqmedkv sqlemeleee
     1081 rnnsdllser isrsreqmeq lrnellqera arqdlecdki slerqnkdlk sriihlegsy
     1141 rsskeglvvq meariaeled rleseerdra nlqlsnrrle rkvkelvmqv ddehlsltdq
     1201 kdqlslrlka mkrqveeaee eidrlesskk klqreleeqm dmnehlqgql nsmkkdlsrl
     1261 kklpskvldd mdddddlstd ggslyeapvs ytfskdstva sqi
//
LOCUS       XP_047289136            1303 aa            linear   PRI 05-AUG-2025
DEFINITION  cingulin-like protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047289136
VERSION     XP_047289136.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433180.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1303
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1303
                     /product="cingulin-like protein 1 isoform X1"
                     /calculated_mol_wt=149036
     Region          <615..1257
                     /region_name="Myosin_tail_1"
                     /note="Myosin tail; pfam01576"
                     /db_xref="CDD:460256"
     CDS             1..1303
                     /gene="CGNL1"
                     /gene_synonym="JACOP; PCING"
                     /coded_by="XM_047433180.1:248..4159"
                     /db_xref="GeneID:84952"
                     /db_xref="HGNC:HGNC:25931"
                     /db_xref="MIM:607856"
ORIGIN      
        1 melyfgeyqh vqqeygvhlr lasddtqksr ssqnskagsy gvsirvqgid ghpyivlnnt
       61 erclagtsfs engppfpppv innlplhssn gsvpkensee lqlpenpyaq pspirnlkqp
      121 llhegkngvl drkdgsvkps hllnfqrhpe llqpydpekn elnlqnhqps esnwlktlte
      181 eginnkkpwt cfpkpsnsqp tspsledpak sgvtairlcs svviedpkkq tsvcvnvqsc
      241 tkervgeeal ftsgrpltah sphahpetkk trpdvlpfrr qdsagpvldg arsrrsssss
      301 ttptsansly rfllddqeca ihadnvnrhe nrryipflpg tgrdidtgsi pgvdqliekf
      361 dqkpglqrrg rsgkrnrint ddrkrsrsvd safpfglqgn seyliefsrn lgkssehllr
      421 psqvcpqrpl sqerrgkqsv grtfaklqga ahgascahsr ppqpnidgkv letegsqest
      481 virapslgaq skkeeevkta tatlmlqnra tatspdsgak kisvktfpsa sntqatpdll
      541 kgqqeltqqt neetakqily nylkegstdn ddatkrkvnl vfekiqtlks raagsaqgnn
      601 qacnstsevk dlleqksklt ievaelqrql qlevknqqni keerermran leelrsqhne
      661 kveenstlqq rleesegelr knleelfqvk mereqhqtei rdlqdqlsem hdeldsakrs
      721 edrekgalie ellqakqdlq dlliakeeqe dllrkrerel talkgalkee vsshdqemdk
      781 lkeqydaelq alresveeat knvevlasrs ntseqdqagt emrvkllqee neklqgrsee
      841 lerrvaqlqr qiedlkgdea kaketlkkye geirqleeal vharkeekea vsarralene
      901 leaaqgnlsq ttqeqkqlse klkeeseqke qlrrlkneme nerwhlgkti eklqkemadi
      961 veasrtstle lqnqldeyke knrrelaemq rqlkektlea eksrltamkm qdemrlmeee
     1021 lrdyqraqde altkrqlleq tlkdleyele akshlkddrs rlvkqmedkv sqlemeleee
     1081 rnnsdllser isrsreqmeq lrnellqera arqdlecdki slerqnkdlk sriihlegsy
     1141 rsskeglvvq meariaeled rleseerdra nlqlsnrrle rkvkelvmqv ddehlsltdq
     1201 kdqlslrlka mkrqveeaee eidrlesskk klqreleeqm dmnehlqgql nsmkkdlsrl
     1261 kklpskvldd mdddddlstd ggslyeapvs ytfskdstva sqi
//
LOCUS       XP_047289137            1303 aa            linear   PRI 05-AUG-2025
DEFINITION  cingulin-like protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047289137
VERSION     XP_047289137.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433181.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1303
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1303
                     /product="cingulin-like protein 1 isoform X1"
                     /calculated_mol_wt=149036
     Region          <615..1257
                     /region_name="Myosin_tail_1"
                     /note="Myosin tail; pfam01576"
                     /db_xref="CDD:460256"
     CDS             1..1303
                     /gene="CGNL1"
                     /gene_synonym="JACOP; PCING"
                     /coded_by="XM_047433181.1:8571..12482"
                     /db_xref="GeneID:84952"
                     /db_xref="HGNC:HGNC:25931"
                     /db_xref="MIM:607856"
ORIGIN      
        1 melyfgeyqh vqqeygvhlr lasddtqksr ssqnskagsy gvsirvqgid ghpyivlnnt
       61 erclagtsfs engppfpppv innlplhssn gsvpkensee lqlpenpyaq pspirnlkqp
      121 llhegkngvl drkdgsvkps hllnfqrhpe llqpydpekn elnlqnhqps esnwlktlte
      181 eginnkkpwt cfpkpsnsqp tspsledpak sgvtairlcs svviedpkkq tsvcvnvqsc
      241 tkervgeeal ftsgrpltah sphahpetkk trpdvlpfrr qdsagpvldg arsrrsssss
      301 ttptsansly rfllddqeca ihadnvnrhe nrryipflpg tgrdidtgsi pgvdqliekf
      361 dqkpglqrrg rsgkrnrint ddrkrsrsvd safpfglqgn seyliefsrn lgkssehllr
      421 psqvcpqrpl sqerrgkqsv grtfaklqga ahgascahsr ppqpnidgkv letegsqest
      481 virapslgaq skkeeevkta tatlmlqnra tatspdsgak kisvktfpsa sntqatpdll
      541 kgqqeltqqt neetakqily nylkegstdn ddatkrkvnl vfekiqtlks raagsaqgnn
      601 qacnstsevk dlleqksklt ievaelqrql qlevknqqni keerermran leelrsqhne
      661 kveenstlqq rleesegelr knleelfqvk mereqhqtei rdlqdqlsem hdeldsakrs
      721 edrekgalie ellqakqdlq dlliakeeqe dllrkrerel talkgalkee vsshdqemdk
      781 lkeqydaelq alresveeat knvevlasrs ntseqdqagt emrvkllqee neklqgrsee
      841 lerrvaqlqr qiedlkgdea kaketlkkye geirqleeal vharkeekea vsarralene
      901 leaaqgnlsq ttqeqkqlse klkeeseqke qlrrlkneme nerwhlgkti eklqkemadi
      961 veasrtstle lqnqldeyke knrrelaemq rqlkektlea eksrltamkm qdemrlmeee
     1021 lrdyqraqde altkrqlleq tlkdleyele akshlkddrs rlvkqmedkv sqlemeleee
     1081 rnnsdllser isrsreqmeq lrnellqera arqdlecdki slerqnkdlk sriihlegsy
     1141 rsskeglvvq meariaeled rleseerdra nlqlsnrrle rkvkelvmqv ddehlsltdq
     1201 kdqlslrlka mkrqveeaee eidrlesskk klqreleeqm dmnehlqgql nsmkkdlsrl
     1261 kklpskvldd mdddddlstd ggslyeapvs ytfskdstva sqi
//
LOCUS       XP_047289138            1303 aa            linear   PRI 05-AUG-2025
DEFINITION  cingulin-like protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047289138
VERSION     XP_047289138.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433182.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1303
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1303
                     /product="cingulin-like protein 1 isoform X1"
                     /calculated_mol_wt=149036
     Region          <615..1257
                     /region_name="Myosin_tail_1"
                     /note="Myosin tail; pfam01576"
                     /db_xref="CDD:460256"
     CDS             1..1303
                     /gene="CGNL1"
                     /gene_synonym="JACOP; PCING"
                     /coded_by="XM_047433182.1:362..4273"
                     /db_xref="GeneID:84952"
                     /db_xref="HGNC:HGNC:25931"
                     /db_xref="MIM:607856"
ORIGIN      
        1 melyfgeyqh vqqeygvhlr lasddtqksr ssqnskagsy gvsirvqgid ghpyivlnnt
       61 erclagtsfs engppfpppv innlplhssn gsvpkensee lqlpenpyaq pspirnlkqp
      121 llhegkngvl drkdgsvkps hllnfqrhpe llqpydpekn elnlqnhqps esnwlktlte
      181 eginnkkpwt cfpkpsnsqp tspsledpak sgvtairlcs svviedpkkq tsvcvnvqsc
      241 tkervgeeal ftsgrpltah sphahpetkk trpdvlpfrr qdsagpvldg arsrrsssss
      301 ttptsansly rfllddqeca ihadnvnrhe nrryipflpg tgrdidtgsi pgvdqliekf
      361 dqkpglqrrg rsgkrnrint ddrkrsrsvd safpfglqgn seyliefsrn lgkssehllr
      421 psqvcpqrpl sqerrgkqsv grtfaklqga ahgascahsr ppqpnidgkv letegsqest
      481 virapslgaq skkeeevkta tatlmlqnra tatspdsgak kisvktfpsa sntqatpdll
      541 kgqqeltqqt neetakqily nylkegstdn ddatkrkvnl vfekiqtlks raagsaqgnn
      601 qacnstsevk dlleqksklt ievaelqrql qlevknqqni keerermran leelrsqhne
      661 kveenstlqq rleesegelr knleelfqvk mereqhqtei rdlqdqlsem hdeldsakrs
      721 edrekgalie ellqakqdlq dlliakeeqe dllrkrerel talkgalkee vsshdqemdk
      781 lkeqydaelq alresveeat knvevlasrs ntseqdqagt emrvkllqee neklqgrsee
      841 lerrvaqlqr qiedlkgdea kaketlkkye geirqleeal vharkeekea vsarralene
      901 leaaqgnlsq ttqeqkqlse klkeeseqke qlrrlkneme nerwhlgkti eklqkemadi
      961 veasrtstle lqnqldeyke knrrelaemq rqlkektlea eksrltamkm qdemrlmeee
     1021 lrdyqraqde altkrqlleq tlkdleyele akshlkddrs rlvkqmedkv sqlemeleee
     1081 rnnsdllser isrsreqmeq lrnellqera arqdlecdki slerqnkdlk sriihlegsy
     1141 rsskeglvvq meariaeled rleseerdra nlqlsnrrle rkvkelvmqv ddehlsltdq
     1201 kdqlslrlka mkrqveeaee eidrlesskk klqreleeqm dmnehlqgql nsmkkdlsrl
     1261 kklpskvldd mdddddlstd ggslyeapvs ytfskdstva sqi
//
LOCUS       XP_047289139            1303 aa            linear   PRI 05-AUG-2025
DEFINITION  cingulin-like protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047289139
VERSION     XP_047289139.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433183.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1303
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1303
                     /product="cingulin-like protein 1 isoform X1"
                     /calculated_mol_wt=149036
     Region          <615..1257
                     /region_name="Myosin_tail_1"
                     /note="Myosin tail; pfam01576"
                     /db_xref="CDD:460256"
     CDS             1..1303
                     /gene="CGNL1"
                     /gene_synonym="JACOP; PCING"
                     /coded_by="XM_047433183.1:740..4651"
                     /db_xref="GeneID:84952"
                     /db_xref="HGNC:HGNC:25931"
                     /db_xref="MIM:607856"
ORIGIN      
        1 melyfgeyqh vqqeygvhlr lasddtqksr ssqnskagsy gvsirvqgid ghpyivlnnt
       61 erclagtsfs engppfpppv innlplhssn gsvpkensee lqlpenpyaq pspirnlkqp
      121 llhegkngvl drkdgsvkps hllnfqrhpe llqpydpekn elnlqnhqps esnwlktlte
      181 eginnkkpwt cfpkpsnsqp tspsledpak sgvtairlcs svviedpkkq tsvcvnvqsc
      241 tkervgeeal ftsgrpltah sphahpetkk trpdvlpfrr qdsagpvldg arsrrsssss
      301 ttptsansly rfllddqeca ihadnvnrhe nrryipflpg tgrdidtgsi pgvdqliekf
      361 dqkpglqrrg rsgkrnrint ddrkrsrsvd safpfglqgn seyliefsrn lgkssehllr
      421 psqvcpqrpl sqerrgkqsv grtfaklqga ahgascahsr ppqpnidgkv letegsqest
      481 virapslgaq skkeeevkta tatlmlqnra tatspdsgak kisvktfpsa sntqatpdll
      541 kgqqeltqqt neetakqily nylkegstdn ddatkrkvnl vfekiqtlks raagsaqgnn
      601 qacnstsevk dlleqksklt ievaelqrql qlevknqqni keerermran leelrsqhne
      661 kveenstlqq rleesegelr knleelfqvk mereqhqtei rdlqdqlsem hdeldsakrs
      721 edrekgalie ellqakqdlq dlliakeeqe dllrkrerel talkgalkee vsshdqemdk
      781 lkeqydaelq alresveeat knvevlasrs ntseqdqagt emrvkllqee neklqgrsee
      841 lerrvaqlqr qiedlkgdea kaketlkkye geirqleeal vharkeekea vsarralene
      901 leaaqgnlsq ttqeqkqlse klkeeseqke qlrrlkneme nerwhlgkti eklqkemadi
      961 veasrtstle lqnqldeyke knrrelaemq rqlkektlea eksrltamkm qdemrlmeee
     1021 lrdyqraqde altkrqlleq tlkdleyele akshlkddrs rlvkqmedkv sqlemeleee
     1081 rnnsdllser isrsreqmeq lrnellqera arqdlecdki slerqnkdlk sriihlegsy
     1141 rsskeglvvq meariaeled rleseerdra nlqlsnrrle rkvkelvmqv ddehlsltdq
     1201 kdqlslrlka mkrqveeaee eidrlesskk klqreleeqm dmnehlqgql nsmkkdlsrl
     1261 kklpskvldd mdddddlstd ggslyeapvs ytfskdstva sqi
//
LOCUS       XP_047289140            1303 aa            linear   PRI 05-AUG-2025
DEFINITION  cingulin-like protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047289140
VERSION     XP_047289140.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433184.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1303
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1303
                     /product="cingulin-like protein 1 isoform X1"
                     /calculated_mol_wt=149036
     Region          <615..1257
                     /region_name="Myosin_tail_1"
                     /note="Myosin tail; pfam01576"
                     /db_xref="CDD:460256"
     CDS             1..1303
                     /gene="CGNL1"
                     /gene_synonym="JACOP; PCING"
                     /coded_by="XM_047433184.1:1983..5894"
                     /db_xref="GeneID:84952"
                     /db_xref="HGNC:HGNC:25931"
                     /db_xref="MIM:607856"
ORIGIN      
        1 melyfgeyqh vqqeygvhlr lasddtqksr ssqnskagsy gvsirvqgid ghpyivlnnt
       61 erclagtsfs engppfpppv innlplhssn gsvpkensee lqlpenpyaq pspirnlkqp
      121 llhegkngvl drkdgsvkps hllnfqrhpe llqpydpekn elnlqnhqps esnwlktlte
      181 eginnkkpwt cfpkpsnsqp tspsledpak sgvtairlcs svviedpkkq tsvcvnvqsc
      241 tkervgeeal ftsgrpltah sphahpetkk trpdvlpfrr qdsagpvldg arsrrsssss
      301 ttptsansly rfllddqeca ihadnvnrhe nrryipflpg tgrdidtgsi pgvdqliekf
      361 dqkpglqrrg rsgkrnrint ddrkrsrsvd safpfglqgn seyliefsrn lgkssehllr
      421 psqvcpqrpl sqerrgkqsv grtfaklqga ahgascahsr ppqpnidgkv letegsqest
      481 virapslgaq skkeeevkta tatlmlqnra tatspdsgak kisvktfpsa sntqatpdll
      541 kgqqeltqqt neetakqily nylkegstdn ddatkrkvnl vfekiqtlks raagsaqgnn
      601 qacnstsevk dlleqksklt ievaelqrql qlevknqqni keerermran leelrsqhne
      661 kveenstlqq rleesegelr knleelfqvk mereqhqtei rdlqdqlsem hdeldsakrs
      721 edrekgalie ellqakqdlq dlliakeeqe dllrkrerel talkgalkee vsshdqemdk
      781 lkeqydaelq alresveeat knvevlasrs ntseqdqagt emrvkllqee neklqgrsee
      841 lerrvaqlqr qiedlkgdea kaketlkkye geirqleeal vharkeekea vsarralene
      901 leaaqgnlsq ttqeqkqlse klkeeseqke qlrrlkneme nerwhlgkti eklqkemadi
      961 veasrtstle lqnqldeyke knrrelaemq rqlkektlea eksrltamkm qdemrlmeee
     1021 lrdyqraqde altkrqlleq tlkdleyele akshlkddrs rlvkqmedkv sqlemeleee
     1081 rnnsdllser isrsreqmeq lrnellqera arqdlecdki slerqnkdlk sriihlegsy
     1141 rsskeglvvq meariaeled rleseerdra nlqlsnrrle rkvkelvmqv ddehlsltdq
     1201 kdqlslrlka mkrqveeaee eidrlesskk klqreleeqm dmnehlqgql nsmkkdlsrl
     1261 kklpskvldd mdddddlstd ggslyeapvs ytfskdstva sqi
//
LOCUS       XP_047289141            1303 aa            linear   PRI 05-AUG-2025
DEFINITION  cingulin-like protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047289141
VERSION     XP_047289141.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433185.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1303
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1303
                     /product="cingulin-like protein 1 isoform X1"
                     /calculated_mol_wt=149036
     Region          <615..1257
                     /region_name="Myosin_tail_1"
                     /note="Myosin tail; pfam01576"
                     /db_xref="CDD:460256"
     CDS             1..1303
                     /gene="CGNL1"
                     /gene_synonym="JACOP; PCING"
                     /coded_by="XM_047433185.1:1631..5542"
                     /db_xref="GeneID:84952"
                     /db_xref="HGNC:HGNC:25931"
                     /db_xref="MIM:607856"
ORIGIN      
        1 melyfgeyqh vqqeygvhlr lasddtqksr ssqnskagsy gvsirvqgid ghpyivlnnt
       61 erclagtsfs engppfpppv innlplhssn gsvpkensee lqlpenpyaq pspirnlkqp
      121 llhegkngvl drkdgsvkps hllnfqrhpe llqpydpekn elnlqnhqps esnwlktlte
      181 eginnkkpwt cfpkpsnsqp tspsledpak sgvtairlcs svviedpkkq tsvcvnvqsc
      241 tkervgeeal ftsgrpltah sphahpetkk trpdvlpfrr qdsagpvldg arsrrsssss
      301 ttptsansly rfllddqeca ihadnvnrhe nrryipflpg tgrdidtgsi pgvdqliekf
      361 dqkpglqrrg rsgkrnrint ddrkrsrsvd safpfglqgn seyliefsrn lgkssehllr
      421 psqvcpqrpl sqerrgkqsv grtfaklqga ahgascahsr ppqpnidgkv letegsqest
      481 virapslgaq skkeeevkta tatlmlqnra tatspdsgak kisvktfpsa sntqatpdll
      541 kgqqeltqqt neetakqily nylkegstdn ddatkrkvnl vfekiqtlks raagsaqgnn
      601 qacnstsevk dlleqksklt ievaelqrql qlevknqqni keerermran leelrsqhne
      661 kveenstlqq rleesegelr knleelfqvk mereqhqtei rdlqdqlsem hdeldsakrs
      721 edrekgalie ellqakqdlq dlliakeeqe dllrkrerel talkgalkee vsshdqemdk
      781 lkeqydaelq alresveeat knvevlasrs ntseqdqagt emrvkllqee neklqgrsee
      841 lerrvaqlqr qiedlkgdea kaketlkkye geirqleeal vharkeekea vsarralene
      901 leaaqgnlsq ttqeqkqlse klkeeseqke qlrrlkneme nerwhlgkti eklqkemadi
      961 veasrtstle lqnqldeyke knrrelaemq rqlkektlea eksrltamkm qdemrlmeee
     1021 lrdyqraqde altkrqlleq tlkdleyele akshlkddrs rlvkqmedkv sqlemeleee
     1081 rnnsdllser isrsreqmeq lrnellqera arqdlecdki slerqnkdlk sriihlegsy
     1141 rsskeglvvq meariaeled rleseerdra nlqlsnrrle rkvkelvmqv ddehlsltdq
     1201 kdqlslrlka mkrqveeaee eidrlesskk klqreleeqm dmnehlqgql nsmkkdlsrl
     1261 kklpskvldd mdddddlstd ggslyeapvs ytfskdstva sqi
//
LOCUS       XP_047289142            1303 aa            linear   PRI 05-AUG-2025
DEFINITION  cingulin-like protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047289142
VERSION     XP_047289142.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433186.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1303
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1303
                     /product="cingulin-like protein 1 isoform X1"
                     /calculated_mol_wt=149036
     Region          <615..1257
                     /region_name="Myosin_tail_1"
                     /note="Myosin tail; pfam01576"
                     /db_xref="CDD:460256"
     CDS             1..1303
                     /gene="CGNL1"
                     /gene_synonym="JACOP; PCING"
                     /coded_by="XM_047433186.1:731..4642"
                     /db_xref="GeneID:84952"
                     /db_xref="HGNC:HGNC:25931"
                     /db_xref="MIM:607856"
ORIGIN      
        1 melyfgeyqh vqqeygvhlr lasddtqksr ssqnskagsy gvsirvqgid ghpyivlnnt
       61 erclagtsfs engppfpppv innlplhssn gsvpkensee lqlpenpyaq pspirnlkqp
      121 llhegkngvl drkdgsvkps hllnfqrhpe llqpydpekn elnlqnhqps esnwlktlte
      181 eginnkkpwt cfpkpsnsqp tspsledpak sgvtairlcs svviedpkkq tsvcvnvqsc
      241 tkervgeeal ftsgrpltah sphahpetkk trpdvlpfrr qdsagpvldg arsrrsssss
      301 ttptsansly rfllddqeca ihadnvnrhe nrryipflpg tgrdidtgsi pgvdqliekf
      361 dqkpglqrrg rsgkrnrint ddrkrsrsvd safpfglqgn seyliefsrn lgkssehllr
      421 psqvcpqrpl sqerrgkqsv grtfaklqga ahgascahsr ppqpnidgkv letegsqest
      481 virapslgaq skkeeevkta tatlmlqnra tatspdsgak kisvktfpsa sntqatpdll
      541 kgqqeltqqt neetakqily nylkegstdn ddatkrkvnl vfekiqtlks raagsaqgnn
      601 qacnstsevk dlleqksklt ievaelqrql qlevknqqni keerermran leelrsqhne
      661 kveenstlqq rleesegelr knleelfqvk mereqhqtei rdlqdqlsem hdeldsakrs
      721 edrekgalie ellqakqdlq dlliakeeqe dllrkrerel talkgalkee vsshdqemdk
      781 lkeqydaelq alresveeat knvevlasrs ntseqdqagt emrvkllqee neklqgrsee
      841 lerrvaqlqr qiedlkgdea kaketlkkye geirqleeal vharkeekea vsarralene
      901 leaaqgnlsq ttqeqkqlse klkeeseqke qlrrlkneme nerwhlgkti eklqkemadi
      961 veasrtstle lqnqldeyke knrrelaemq rqlkektlea eksrltamkm qdemrlmeee
     1021 lrdyqraqde altkrqlleq tlkdleyele akshlkddrs rlvkqmedkv sqlemeleee
     1081 rnnsdllser isrsreqmeq lrnellqera arqdlecdki slerqnkdlk sriihlegsy
     1141 rsskeglvvq meariaeled rleseerdra nlqlsnrrle rkvkelvmqv ddehlsltdq
     1201 kdqlslrlka mkrqveeaee eidrlesskk klqreleeqm dmnehlqgql nsmkkdlsrl
     1261 kklpskvldd mdddddlstd ggslyeapvs ytfskdstva sqi
//
LOCUS       XP_047289143            1303 aa            linear   PRI 05-AUG-2025
DEFINITION  cingulin-like protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047289143
VERSION     XP_047289143.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433187.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1303
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1303
                     /product="cingulin-like protein 1 isoform X1"
                     /calculated_mol_wt=149036
     Region          <615..1257
                     /region_name="Myosin_tail_1"
                     /note="Myosin tail; pfam01576"
                     /db_xref="CDD:460256"
     CDS             1..1303
                     /gene="CGNL1"
                     /gene_synonym="JACOP; PCING"
                     /coded_by="XM_047433187.1:378..4289"
                     /db_xref="GeneID:84952"
                     /db_xref="HGNC:HGNC:25931"
                     /db_xref="MIM:607856"
ORIGIN      
        1 melyfgeyqh vqqeygvhlr lasddtqksr ssqnskagsy gvsirvqgid ghpyivlnnt
       61 erclagtsfs engppfpppv innlplhssn gsvpkensee lqlpenpyaq pspirnlkqp
      121 llhegkngvl drkdgsvkps hllnfqrhpe llqpydpekn elnlqnhqps esnwlktlte
      181 eginnkkpwt cfpkpsnsqp tspsledpak sgvtairlcs svviedpkkq tsvcvnvqsc
      241 tkervgeeal ftsgrpltah sphahpetkk trpdvlpfrr qdsagpvldg arsrrsssss
      301 ttptsansly rfllddqeca ihadnvnrhe nrryipflpg tgrdidtgsi pgvdqliekf
      361 dqkpglqrrg rsgkrnrint ddrkrsrsvd safpfglqgn seyliefsrn lgkssehllr
      421 psqvcpqrpl sqerrgkqsv grtfaklqga ahgascahsr ppqpnidgkv letegsqest
      481 virapslgaq skkeeevkta tatlmlqnra tatspdsgak kisvktfpsa sntqatpdll
      541 kgqqeltqqt neetakqily nylkegstdn ddatkrkvnl vfekiqtlks raagsaqgnn
      601 qacnstsevk dlleqksklt ievaelqrql qlevknqqni keerermran leelrsqhne
      661 kveenstlqq rleesegelr knleelfqvk mereqhqtei rdlqdqlsem hdeldsakrs
      721 edrekgalie ellqakqdlq dlliakeeqe dllrkrerel talkgalkee vsshdqemdk
      781 lkeqydaelq alresveeat knvevlasrs ntseqdqagt emrvkllqee neklqgrsee
      841 lerrvaqlqr qiedlkgdea kaketlkkye geirqleeal vharkeekea vsarralene
      901 leaaqgnlsq ttqeqkqlse klkeeseqke qlrrlkneme nerwhlgkti eklqkemadi
      961 veasrtstle lqnqldeyke knrrelaemq rqlkektlea eksrltamkm qdemrlmeee
     1021 lrdyqraqde altkrqlleq tlkdleyele akshlkddrs rlvkqmedkv sqlemeleee
     1081 rnnsdllser isrsreqmeq lrnellqera arqdlecdki slerqnkdlk sriihlegsy
     1141 rsskeglvvq meariaeled rleseerdra nlqlsnrrle rkvkelvmqv ddehlsltdq
     1201 kdqlslrlka mkrqveeaee eidrlesskk klqreleeqm dmnehlqgql nsmkkdlsrl
     1261 kklpskvldd mdddddlstd ggslyeapvs ytfskdstva sqi
//
LOCUS       XP_011520423            1303 aa            linear   PRI 05-AUG-2025
DEFINITION  cingulin-like protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_011520423
VERSION     XP_011520423.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522121.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1303
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1303
                     /product="cingulin-like protein 1 isoform X1"
                     /calculated_mol_wt=149036
     Region          <615..1257
                     /region_name="Myosin_tail_1"
                     /note="Myosin tail; pfam01576"
                     /db_xref="CDD:460256"
     CDS             1..1303
                     /gene="CGNL1"
                     /gene_synonym="JACOP; PCING"
                     /coded_by="XM_011522121.3:677..4588"
                     /db_xref="GeneID:84952"
                     /db_xref="HGNC:HGNC:25931"
                     /db_xref="MIM:607856"
ORIGIN      
        1 melyfgeyqh vqqeygvhlr lasddtqksr ssqnskagsy gvsirvqgid ghpyivlnnt
       61 erclagtsfs engppfpppv innlplhssn gsvpkensee lqlpenpyaq pspirnlkqp
      121 llhegkngvl drkdgsvkps hllnfqrhpe llqpydpekn elnlqnhqps esnwlktlte
      181 eginnkkpwt cfpkpsnsqp tspsledpak sgvtairlcs svviedpkkq tsvcvnvqsc
      241 tkervgeeal ftsgrpltah sphahpetkk trpdvlpfrr qdsagpvldg arsrrsssss
      301 ttptsansly rfllddqeca ihadnvnrhe nrryipflpg tgrdidtgsi pgvdqliekf
      361 dqkpglqrrg rsgkrnrint ddrkrsrsvd safpfglqgn seyliefsrn lgkssehllr
      421 psqvcpqrpl sqerrgkqsv grtfaklqga ahgascahsr ppqpnidgkv letegsqest
      481 virapslgaq skkeeevkta tatlmlqnra tatspdsgak kisvktfpsa sntqatpdll
      541 kgqqeltqqt neetakqily nylkegstdn ddatkrkvnl vfekiqtlks raagsaqgnn
      601 qacnstsevk dlleqksklt ievaelqrql qlevknqqni keerermran leelrsqhne
      661 kveenstlqq rleesegelr knleelfqvk mereqhqtei rdlqdqlsem hdeldsakrs
      721 edrekgalie ellqakqdlq dlliakeeqe dllrkrerel talkgalkee vsshdqemdk
      781 lkeqydaelq alresveeat knvevlasrs ntseqdqagt emrvkllqee neklqgrsee
      841 lerrvaqlqr qiedlkgdea kaketlkkye geirqleeal vharkeekea vsarralene
      901 leaaqgnlsq ttqeqkqlse klkeeseqke qlrrlkneme nerwhlgkti eklqkemadi
      961 veasrtstle lqnqldeyke knrrelaemq rqlkektlea eksrltamkm qdemrlmeee
     1021 lrdyqraqde altkrqlleq tlkdleyele akshlkddrs rlvkqmedkv sqlemeleee
     1081 rnnsdllser isrsreqmeq lrnellqera arqdlecdki slerqnkdlk sriihlegsy
     1141 rsskeglvvq meariaeled rleseerdra nlqlsnrrle rkvkelvmqv ddehlsltdq
     1201 kdqlslrlka mkrqveeaee eidrlesskk klqreleeqm dmnehlqgql nsmkkdlsrl
     1261 kklpskvldd mdddddlstd ggslyeapvs ytfskdstva sqi
//
LOCUS       XP_047289144            1302 aa            linear   PRI 05-AUG-2025
DEFINITION  cingulin-like protein 1 isoform X2 [Homo sapiens].
ACCESSION   XP_047289144
VERSION     XP_047289144.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433188.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1302
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1302
                     /product="cingulin-like protein 1 isoform X2"
                     /calculated_mol_wt=148949
     Region          <615..1257
                     /region_name="Myosin_tail_1"
                     /note="Myosin tail; pfam01576"
                     /db_xref="CDD:460256"
     CDS             1..1302
                     /gene="CGNL1"
                     /gene_synonym="JACOP; PCING"
                     /coded_by="XM_047433188.1:133..4041"
                     /db_xref="GeneID:84952"
                     /db_xref="HGNC:HGNC:25931"
                     /db_xref="MIM:607856"
ORIGIN      
        1 melyfgeyqh vqqeygvhlr lasddtqksr ssqnskagsy gvsirvqgid ghpyivlnnt
       61 erclagtsfs engppfpppv innlplhssn gsvpkensee lqlpenpyaq pspirnlkqp
      121 llhegkngvl drkdgsvkps hllnfqrhpe llqpydpekn elnlqnhqps esnwlktlte
      181 eginnkkpwt cfpkpsnsqp tspsledpak sgvtairlcs svviedpkkq tsvcvnvqsc
      241 tkervgeeal ftsgrpltah sphahpetkk trpdvlpfrr qdsagpvldg arsrrsssss
      301 ttptsansly rfllddqeca ihadnvnrhe nrryipflpg tgrdidtgsi pgvdqliekf
      361 dqkpglqrrg rsgkrnrint ddrkrsrsvd safpfglqgn seyliefsrn lgkssehllr
      421 psqvcpqrpl sqerrgkqsv grtfaklqga ahgascahsr ppqpnidgkv letegsqest
      481 virapslgaq skkeeevkta tatlmlqnra tatspdsgak kisvktfpsa sntqatpdll
      541 kgqqeltqqt neetakqily nylkegstdn ddatkrkvnl vfekiqtlks raagsaqgnn
      601 qacnstsevk dlleqksklt ievaelqrql qlevknqqni keerermran leelrsqhne
      661 kveenstlqq rleesegelr knleelfqvk mereqhqtei rdlqdqlsem hdeldsakrs
      721 edrekgalie ellqakqdlq dlliakeeqe dllrkrerel talkgalkee vsshdqemdk
      781 lkeqydaelq alresveeat knvevlasrs ntseqdqagt emrvkllqee neklqgrsee
      841 lerrvaqlqr qiedlkgdea kaketlkkye geirqleeal vharkeekea vsarralene
      901 leaaqgnlsq ttqeqkqlse klkeeseqke qlrrlkneme nerwhlgkti eklqkemadi
      961 veasrtstle lqnqldeyke knrrelaemq rqlkektlea eksrltamkm qdemrlmeee
     1021 lrdyqraqde altkrqlleq tlkdleyele akshlkddrs rlvkqmedkv sqlemeleee
     1081 rnnsdllser isrsreqmeq lrnellqera arqdlecdki slerqnkdlk sriihlegsy
     1141 rsskeglvvq meariaeled rleseerdra nlqlsnrrle rkvkelvmqv ddehlsltdq
     1201 kdqlslrlka mkrqveeaee eidrlesskk klqreleeqm dmnehlqgql nsmkkdlrlk
     1261 klpskvlddm dddddlstdg gslyeapvsy tfskdstvas qi
//
LOCUS       XP_047289145            1302 aa            linear   PRI 05-AUG-2025
DEFINITION  cingulin-like protein 1 isoform X2 [Homo sapiens].
ACCESSION   XP_047289145
VERSION     XP_047289145.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433189.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1302
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1302
                     /product="cingulin-like protein 1 isoform X2"
                     /calculated_mol_wt=148949
     Region          <615..1257
                     /region_name="Myosin_tail_1"
                     /note="Myosin tail; pfam01576"
                     /db_xref="CDD:460256"
     CDS             1..1302
                     /gene="CGNL1"
                     /gene_synonym="JACOP; PCING"
                     /coded_by="XM_047433189.1:739..4647"
                     /db_xref="GeneID:84952"
                     /db_xref="HGNC:HGNC:25931"
                     /db_xref="MIM:607856"
ORIGIN      
        1 melyfgeyqh vqqeygvhlr lasddtqksr ssqnskagsy gvsirvqgid ghpyivlnnt
       61 erclagtsfs engppfpppv innlplhssn gsvpkensee lqlpenpyaq pspirnlkqp
      121 llhegkngvl drkdgsvkps hllnfqrhpe llqpydpekn elnlqnhqps esnwlktlte
      181 eginnkkpwt cfpkpsnsqp tspsledpak sgvtairlcs svviedpkkq tsvcvnvqsc
      241 tkervgeeal ftsgrpltah sphahpetkk trpdvlpfrr qdsagpvldg arsrrsssss
      301 ttptsansly rfllddqeca ihadnvnrhe nrryipflpg tgrdidtgsi pgvdqliekf
      361 dqkpglqrrg rsgkrnrint ddrkrsrsvd safpfglqgn seyliefsrn lgkssehllr
      421 psqvcpqrpl sqerrgkqsv grtfaklqga ahgascahsr ppqpnidgkv letegsqest
      481 virapslgaq skkeeevkta tatlmlqnra tatspdsgak kisvktfpsa sntqatpdll
      541 kgqqeltqqt neetakqily nylkegstdn ddatkrkvnl vfekiqtlks raagsaqgnn
      601 qacnstsevk dlleqksklt ievaelqrql qlevknqqni keerermran leelrsqhne
      661 kveenstlqq rleesegelr knleelfqvk mereqhqtei rdlqdqlsem hdeldsakrs
      721 edrekgalie ellqakqdlq dlliakeeqe dllrkrerel talkgalkee vsshdqemdk
      781 lkeqydaelq alresveeat knvevlasrs ntseqdqagt emrvkllqee neklqgrsee
      841 lerrvaqlqr qiedlkgdea kaketlkkye geirqleeal vharkeekea vsarralene
      901 leaaqgnlsq ttqeqkqlse klkeeseqke qlrrlkneme nerwhlgkti eklqkemadi
      961 veasrtstle lqnqldeyke knrrelaemq rqlkektlea eksrltamkm qdemrlmeee
     1021 lrdyqraqde altkrqlleq tlkdleyele akshlkddrs rlvkqmedkv sqlemeleee
     1081 rnnsdllser isrsreqmeq lrnellqera arqdlecdki slerqnkdlk sriihlegsy
     1141 rsskeglvvq meariaeled rleseerdra nlqlsnrrle rkvkelvmqv ddehlsltdq
     1201 kdqlslrlka mkrqveeaee eidrlesskk klqreleeqm dmnehlqgql nsmkkdlrlk
     1261 klpskvlddm dddddlstdg gslyeapvsy tfskdstvas qi
//
LOCUS       XP_047289146            1302 aa            linear   PRI 05-AUG-2025
DEFINITION  cingulin-like protein 1 isoform X2 [Homo sapiens].
ACCESSION   XP_047289146
VERSION     XP_047289146.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433190.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1302
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1302
                     /product="cingulin-like protein 1 isoform X2"
                     /calculated_mol_wt=148949
     Region          <615..1257
                     /region_name="Myosin_tail_1"
                     /note="Myosin tail; pfam01576"
                     /db_xref="CDD:460256"
     CDS             1..1302
                     /gene="CGNL1"
                     /gene_synonym="JACOP; PCING"
                     /coded_by="XM_047433190.1:248..4156"
                     /db_xref="GeneID:84952"
                     /db_xref="HGNC:HGNC:25931"
                     /db_xref="MIM:607856"
ORIGIN      
        1 melyfgeyqh vqqeygvhlr lasddtqksr ssqnskagsy gvsirvqgid ghpyivlnnt
       61 erclagtsfs engppfpppv innlplhssn gsvpkensee lqlpenpyaq pspirnlkqp
      121 llhegkngvl drkdgsvkps hllnfqrhpe llqpydpekn elnlqnhqps esnwlktlte
      181 eginnkkpwt cfpkpsnsqp tspsledpak sgvtairlcs svviedpkkq tsvcvnvqsc
      241 tkervgeeal ftsgrpltah sphahpetkk trpdvlpfrr qdsagpvldg arsrrsssss
      301 ttptsansly rfllddqeca ihadnvnrhe nrryipflpg tgrdidtgsi pgvdqliekf
      361 dqkpglqrrg rsgkrnrint ddrkrsrsvd safpfglqgn seyliefsrn lgkssehllr
      421 psqvcpqrpl sqerrgkqsv grtfaklqga ahgascahsr ppqpnidgkv letegsqest
      481 virapslgaq skkeeevkta tatlmlqnra tatspdsgak kisvktfpsa sntqatpdll
      541 kgqqeltqqt neetakqily nylkegstdn ddatkrkvnl vfekiqtlks raagsaqgnn
      601 qacnstsevk dlleqksklt ievaelqrql qlevknqqni keerermran leelrsqhne
      661 kveenstlqq rleesegelr knleelfqvk mereqhqtei rdlqdqlsem hdeldsakrs
      721 edrekgalie ellqakqdlq dlliakeeqe dllrkrerel talkgalkee vsshdqemdk
      781 lkeqydaelq alresveeat knvevlasrs ntseqdqagt emrvkllqee neklqgrsee
      841 lerrvaqlqr qiedlkgdea kaketlkkye geirqleeal vharkeekea vsarralene
      901 leaaqgnlsq ttqeqkqlse klkeeseqke qlrrlkneme nerwhlgkti eklqkemadi
      961 veasrtstle lqnqldeyke knrrelaemq rqlkektlea eksrltamkm qdemrlmeee
     1021 lrdyqraqde altkrqlleq tlkdleyele akshlkddrs rlvkqmedkv sqlemeleee
     1081 rnnsdllser isrsreqmeq lrnellqera arqdlecdki slerqnkdlk sriihlegsy
     1141 rsskeglvvq meariaeled rleseerdra nlqlsnrrle rkvkelvmqv ddehlsltdq
     1201 kdqlslrlka mkrqveeaee eidrlesskk klqreleeqm dmnehlqgql nsmkkdlrlk
     1261 klpskvlddm dddddlstdg gslyeapvsy tfskdstvas qi
//
LOCUS       XP_016878175            1302 aa            linear   PRI 05-AUG-2025
DEFINITION  cingulin-like protein 1 isoform X2 [Homo sapiens].
ACCESSION   XP_016878175
VERSION     XP_016878175.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022686.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1302
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1302
                     /product="cingulin-like protein 1 isoform X2"
                     /calculated_mol_wt=148949
     Region          <615..1257
                     /region_name="Myosin_tail_1"
                     /note="Myosin tail; pfam01576"
                     /db_xref="CDD:460256"
     CDS             1..1302
                     /gene="CGNL1"
                     /gene_synonym="JACOP; PCING"
                     /coded_by="XM_017022686.2:2960..6868"
                     /db_xref="GeneID:84952"
                     /db_xref="HGNC:HGNC:25931"
                     /db_xref="MIM:607856"
ORIGIN      
        1 melyfgeyqh vqqeygvhlr lasddtqksr ssqnskagsy gvsirvqgid ghpyivlnnt
       61 erclagtsfs engppfpppv innlplhssn gsvpkensee lqlpenpyaq pspirnlkqp
      121 llhegkngvl drkdgsvkps hllnfqrhpe llqpydpekn elnlqnhqps esnwlktlte
      181 eginnkkpwt cfpkpsnsqp tspsledpak sgvtairlcs svviedpkkq tsvcvnvqsc
      241 tkervgeeal ftsgrpltah sphahpetkk trpdvlpfrr qdsagpvldg arsrrsssss
      301 ttptsansly rfllddqeca ihadnvnrhe nrryipflpg tgrdidtgsi pgvdqliekf
      361 dqkpglqrrg rsgkrnrint ddrkrsrsvd safpfglqgn seyliefsrn lgkssehllr
      421 psqvcpqrpl sqerrgkqsv grtfaklqga ahgascahsr ppqpnidgkv letegsqest
      481 virapslgaq skkeeevkta tatlmlqnra tatspdsgak kisvktfpsa sntqatpdll
      541 kgqqeltqqt neetakqily nylkegstdn ddatkrkvnl vfekiqtlks raagsaqgnn
      601 qacnstsevk dlleqksklt ievaelqrql qlevknqqni keerermran leelrsqhne
      661 kveenstlqq rleesegelr knleelfqvk mereqhqtei rdlqdqlsem hdeldsakrs
      721 edrekgalie ellqakqdlq dlliakeeqe dllrkrerel talkgalkee vsshdqemdk
      781 lkeqydaelq alresveeat knvevlasrs ntseqdqagt emrvkllqee neklqgrsee
      841 lerrvaqlqr qiedlkgdea kaketlkkye geirqleeal vharkeekea vsarralene
      901 leaaqgnlsq ttqeqkqlse klkeeseqke qlrrlkneme nerwhlgkti eklqkemadi
      961 veasrtstle lqnqldeyke knrrelaemq rqlkektlea eksrltamkm qdemrlmeee
     1021 lrdyqraqde altkrqlleq tlkdleyele akshlkddrs rlvkqmedkv sqlemeleee
     1081 rnnsdllser isrsreqmeq lrnellqera arqdlecdki slerqnkdlk sriihlegsy
     1141 rsskeglvvq meariaeled rleseerdra nlqlsnrrle rkvkelvmqv ddehlsltdq
     1201 kdqlslrlka mkrqveeaee eidrlesskk klqreleeqm dmnehlqgql nsmkkdlrlk
     1261 klpskvlddm dddddlstdg gslyeapvsy tfskdstvas qi
//
LOCUS       XP_047289147            1302 aa            linear   PRI 05-AUG-2025
DEFINITION  cingulin-like protein 1 isoform X2 [Homo sapiens].
ACCESSION   XP_047289147
VERSION     XP_047289147.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433191.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1302
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1302
                     /product="cingulin-like protein 1 isoform X2"
                     /calculated_mol_wt=148949
     Region          <615..1257
                     /region_name="Myosin_tail_1"
                     /note="Myosin tail; pfam01576"
                     /db_xref="CDD:460256"
     CDS             1..1302
                     /gene="CGNL1"
                     /gene_synonym="JACOP; PCING"
                     /coded_by="XM_047433191.1:1223..5131"
                     /db_xref="GeneID:84952"
                     /db_xref="HGNC:HGNC:25931"
                     /db_xref="MIM:607856"
ORIGIN      
        1 melyfgeyqh vqqeygvhlr lasddtqksr ssqnskagsy gvsirvqgid ghpyivlnnt
       61 erclagtsfs engppfpppv innlplhssn gsvpkensee lqlpenpyaq pspirnlkqp
      121 llhegkngvl drkdgsvkps hllnfqrhpe llqpydpekn elnlqnhqps esnwlktlte
      181 eginnkkpwt cfpkpsnsqp tspsledpak sgvtairlcs svviedpkkq tsvcvnvqsc
      241 tkervgeeal ftsgrpltah sphahpetkk trpdvlpfrr qdsagpvldg arsrrsssss
      301 ttptsansly rfllddqeca ihadnvnrhe nrryipflpg tgrdidtgsi pgvdqliekf
      361 dqkpglqrrg rsgkrnrint ddrkrsrsvd safpfglqgn seyliefsrn lgkssehllr
      421 psqvcpqrpl sqerrgkqsv grtfaklqga ahgascahsr ppqpnidgkv letegsqest
      481 virapslgaq skkeeevkta tatlmlqnra tatspdsgak kisvktfpsa sntqatpdll
      541 kgqqeltqqt neetakqily nylkegstdn ddatkrkvnl vfekiqtlks raagsaqgnn
      601 qacnstsevk dlleqksklt ievaelqrql qlevknqqni keerermran leelrsqhne
      661 kveenstlqq rleesegelr knleelfqvk mereqhqtei rdlqdqlsem hdeldsakrs
      721 edrekgalie ellqakqdlq dlliakeeqe dllrkrerel talkgalkee vsshdqemdk
      781 lkeqydaelq alresveeat knvevlasrs ntseqdqagt emrvkllqee neklqgrsee
      841 lerrvaqlqr qiedlkgdea kaketlkkye geirqleeal vharkeekea vsarralene
      901 leaaqgnlsq ttqeqkqlse klkeeseqke qlrrlkneme nerwhlgkti eklqkemadi
      961 veasrtstle lqnqldeyke knrrelaemq rqlkektlea eksrltamkm qdemrlmeee
     1021 lrdyqraqde altkrqlleq tlkdleyele akshlkddrs rlvkqmedkv sqlemeleee
     1081 rnnsdllser isrsreqmeq lrnellqera arqdlecdki slerqnkdlk sriihlegsy
     1141 rsskeglvvq meariaeled rleseerdra nlqlsnrrle rkvkelvmqv ddehlsltdq
     1201 kdqlslrlka mkrqveeaee eidrlesskk klqreleeqm dmnehlqgql nsmkkdlrlk
     1261 klpskvlddm dddddlstdg gslyeapvsy tfskdstvas qi
//
LOCUS       XP_047289148            1302 aa            linear   PRI 05-AUG-2025
DEFINITION  cingulin-like protein 1 isoform X2 [Homo sapiens].
ACCESSION   XP_047289148
VERSION     XP_047289148.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433192.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1302
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1302
                     /product="cingulin-like protein 1 isoform X2"
                     /calculated_mol_wt=148949
     Region          <615..1257
                     /region_name="Myosin_tail_1"
                     /note="Myosin tail; pfam01576"
                     /db_xref="CDD:460256"
     CDS             1..1302
                     /gene="CGNL1"
                     /gene_synonym="JACOP; PCING"
                     /coded_by="XM_047433192.1:544..4452"
                     /db_xref="GeneID:84952"
                     /db_xref="HGNC:HGNC:25931"
                     /db_xref="MIM:607856"
ORIGIN      
        1 melyfgeyqh vqqeygvhlr lasddtqksr ssqnskagsy gvsirvqgid ghpyivlnnt
       61 erclagtsfs engppfpppv innlplhssn gsvpkensee lqlpenpyaq pspirnlkqp
      121 llhegkngvl drkdgsvkps hllnfqrhpe llqpydpekn elnlqnhqps esnwlktlte
      181 eginnkkpwt cfpkpsnsqp tspsledpak sgvtairlcs svviedpkkq tsvcvnvqsc
      241 tkervgeeal ftsgrpltah sphahpetkk trpdvlpfrr qdsagpvldg arsrrsssss
      301 ttptsansly rfllddqeca ihadnvnrhe nrryipflpg tgrdidtgsi pgvdqliekf
      361 dqkpglqrrg rsgkrnrint ddrkrsrsvd safpfglqgn seyliefsrn lgkssehllr
      421 psqvcpqrpl sqerrgkqsv grtfaklqga ahgascahsr ppqpnidgkv letegsqest
      481 virapslgaq skkeeevkta tatlmlqnra tatspdsgak kisvktfpsa sntqatpdll
      541 kgqqeltqqt neetakqily nylkegstdn ddatkrkvnl vfekiqtlks raagsaqgnn
      601 qacnstsevk dlleqksklt ievaelqrql qlevknqqni keerermran leelrsqhne
      661 kveenstlqq rleesegelr knleelfqvk mereqhqtei rdlqdqlsem hdeldsakrs
      721 edrekgalie ellqakqdlq dlliakeeqe dllrkrerel talkgalkee vsshdqemdk
      781 lkeqydaelq alresveeat knvevlasrs ntseqdqagt emrvkllqee neklqgrsee
      841 lerrvaqlqr qiedlkgdea kaketlkkye geirqleeal vharkeekea vsarralene
      901 leaaqgnlsq ttqeqkqlse klkeeseqke qlrrlkneme nerwhlgkti eklqkemadi
      961 veasrtstle lqnqldeyke knrrelaemq rqlkektlea eksrltamkm qdemrlmeee
     1021 lrdyqraqde altkrqlleq tlkdleyele akshlkddrs rlvkqmedkv sqlemeleee
     1081 rnnsdllser isrsreqmeq lrnellqera arqdlecdki slerqnkdlk sriihlegsy
     1141 rsskeglvvq meariaeled rleseerdra nlqlsnrrle rkvkelvmqv ddehlsltdq
     1201 kdqlslrlka mkrqveeaee eidrlesskk klqreleeqm dmnehlqgql nsmkkdlrlk
     1261 klpskvlddm dddddlstdg gslyeapvsy tfskdstvas qi
//
LOCUS       XP_047289149             481 aa            linear   PRI 05-AUG-2025
DEFINITION  FERM domain-containing protein 5 isoform X1 [Homo sapiens].
ACCESSION   XP_047289149
VERSION     XP_047289149.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433193.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..481
                     /product="FERM domain-containing protein 5 isoform X1"
                     /calculated_mol_wt=54363
     Region          11..121
                     /region_name="FERM_M"
                     /note="FERM central domain; pfam00373"
                     /db_xref="CDD:459788"
     Region          102..206
                     /region_name="FERM_C_FRMD3_FRMD5"
                     /note="FERM domain C-lobe of FERM domain-containing
                     protein 3 and 5 (FRMD3 and 5); cd13192"
                     /db_xref="CDD:270013"
     Site            order(125,142,144,150)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:270013"
     Site            order(154,159..162,195,199,202..203)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270013"
     Site            195..206
                     /site_type="other"
                     /note="putative actin binding site 2 [polypeptide
                     binding]"
                     /db_xref="CDD:270013"
     Region          220..265
                     /region_name="FA"
                     /note="FERM adjacent (FA); pfam08736"
                     /db_xref="CDD:462582"
     CDS             1..481
                     /gene="FRMD5"
                     /gene_synonym="NEDEMA"
                     /coded_by="XM_047433193.1:386..1831"
                     /db_xref="GeneID:84978"
                     /db_xref="HGNC:HGNC:28214"
                     /db_xref="MIM:616309"
ORIGIN      
        1 mcfrvkfypa dpaalkeeit rylvflqikr dlyhgrllck tsdaallaay ilqaeigdyd
       61 sgkhpegyss kfqffpkhse klerkiaeih ktelsgqtpa tselnflrka qtletygvdp
      121 hpckdvsgna aflaftpfgf vvlqgnkrvh fikwnevtkl kfegktfyly vsqkeekkii
      181 ltyfaptpea ckhlwkcgie nqafykleks sqvrtvsssn lffkgsrfry sgrvakevme
      241 ssakikrepp eihragmvps rscpsithgp rlssvprtrr ravhisimeg leslrdsahs
      301 tpvrstshgd tflphvrssr tdsnervavi adeayspads vlptpvaehs lelmllsrqi
      361 ngatcsieee keseastpta tevealggel ralcqghsgp eeeqvnkfvl svlrlllvtm
      421 gllfvlllll iiltesdldi affrdirqtp efeqfhyqyf cplrrwfack irsvvsllid
      481 t
//
LOCUS       XP_047289150             481 aa            linear   PRI 05-AUG-2025
DEFINITION  FERM domain-containing protein 5 isoform X1 [Homo sapiens].
ACCESSION   XP_047289150
VERSION     XP_047289150.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433194.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..481
                     /product="FERM domain-containing protein 5 isoform X1"
                     /calculated_mol_wt=54363
     Region          11..121
                     /region_name="FERM_M"
                     /note="FERM central domain; pfam00373"
                     /db_xref="CDD:459788"
     Region          102..206
                     /region_name="FERM_C_FRMD3_FRMD5"
                     /note="FERM domain C-lobe of FERM domain-containing
                     protein 3 and 5 (FRMD3 and 5); cd13192"
                     /db_xref="CDD:270013"
     Site            order(125,142,144,150)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:270013"
     Site            order(154,159..162,195,199,202..203)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270013"
     Site            195..206
                     /site_type="other"
                     /note="putative actin binding site 2 [polypeptide
                     binding]"
                     /db_xref="CDD:270013"
     Region          220..265
                     /region_name="FA"
                     /note="FERM adjacent (FA); pfam08736"
                     /db_xref="CDD:462582"
     CDS             1..481
                     /gene="FRMD5"
                     /gene_synonym="NEDEMA"
                     /coded_by="XM_047433194.1:185..1630"
                     /db_xref="GeneID:84978"
                     /db_xref="HGNC:HGNC:28214"
                     /db_xref="MIM:616309"
ORIGIN      
        1 mcfrvkfypa dpaalkeeit rylvflqikr dlyhgrllck tsdaallaay ilqaeigdyd
       61 sgkhpegyss kfqffpkhse klerkiaeih ktelsgqtpa tselnflrka qtletygvdp
      121 hpckdvsgna aflaftpfgf vvlqgnkrvh fikwnevtkl kfegktfyly vsqkeekkii
      181 ltyfaptpea ckhlwkcgie nqafykleks sqvrtvsssn lffkgsrfry sgrvakevme
      241 ssakikrepp eihragmvps rscpsithgp rlssvprtrr ravhisimeg leslrdsahs
      301 tpvrstshgd tflphvrssr tdsnervavi adeayspads vlptpvaehs lelmllsrqi
      361 ngatcsieee keseastpta tevealggel ralcqghsgp eeeqvnkfvl svlrlllvtm
      421 gllfvlllll iiltesdldi affrdirqtp efeqfhyqyf cplrrwfack irsvvsllid
      481 t
//
LOCUS       XP_047289151             243 aa            linear   PRI 05-AUG-2025
DEFINITION  FERM domain-containing protein 5 isoform X2 [Homo sapiens].
ACCESSION   XP_047289151
VERSION     XP_047289151.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433195.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..243
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..243
                     /product="FERM domain-containing protein 5 isoform X2"
                     /calculated_mol_wt=27001
     CDS             1..243
                     /gene="FRMD5"
                     /gene_synonym="NEDEMA"
                     /coded_by="XM_047433195.1:794..1525"
                     /db_xref="GeneID:84978"
                     /db_xref="HGNC:HGNC:28214"
                     /db_xref="MIM:616309"
ORIGIN      
        1 messakikre ppeihragmv psrscpsith gprlssvprt rrravhisim egleslrdsa
       61 hstpvrstsh gdtflphvrs srtdsnerva viadeayspa dsvlptpvae hslelmllsr
      121 qingatcsie eekeseastp tatevealgg elralcqghs gpeeeqvnkf vlsvlrlllv
      181 tmgllfvlll lliiltesdl diaffrdirq tpefeqfhyq yfcplrrwfa ckirsvvsll
      241 idt
//
LOCUS       XP_011520426             420 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin-like protein 7 isoform X1 [Homo sapiens].
ACCESSION   XP_011520426
VERSION     XP_011520426.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522124.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..420
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..420
                     /product="ubiquitin-like protein 7 isoform X1"
                     /calculated_mol_wt=45006
     Region          47..138
                     /region_name="Ubl_UBL7"
                     /note="ubiquitin-like (Ubl) domain found in ubiquitin-like
                     protein 7 (UBL7) and similar proteins; cd01815"
                     /db_xref="CDD:340513"
     Region          <386..415
                     /region_name="UBA_UBL7"
                     /note="UBA domain found in ubiquitin-like protein 7 (UBL7)
                     and similar proteins; cd14326"
                     /db_xref="CDD:270511"
     CDS             1..420
                     /gene="UBL7"
                     /gene_synonym="BMSC-UbP; TCBA1"
                     /coded_by="XM_011522124.3:293..1555"
                     /db_xref="GeneID:84993"
                     /db_xref="HGNC:HGNC:28221"
                     /db_xref="MIM:609748"
ORIGIN      
        1 mmtitrtyla lqdssavrvs dlfsgvpcmp grkrererer mslsdwhlav kladqpltpk
       61 silrlpetel geyslggysi sflkqliagk lqesvpdpel idliycgrkl kddqtldfyg
      121 iqpgstvhvl rkswpepdqk pepvdkvaam refrvlhtal hssssyreav fkmlsnkesl
      181 dqiivatpgl ssdpialgvl qdkdlfsvfa dpnmldtlvp ahpalvnaiv lvlhsvagsa
      241 pmpgtdsssr smpsssyrdm pggflfegls ddeddfhpnt rstpssstps srpaslgysg
      301 aagprpitqs elatalalas tpessshtpt pgtqghssgt spmssgvqsg tpitndlfsq
      361 alqhalqasg qpslqsqwqp qlqqlrdmgi qddelslral qatggdiqaa lelifaggap
//
LOCUS       XP_011520428             660 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 SUMO-protein ligase PIAS1 isoform X1 [Homo sapiens].
ACCESSION   XP_011520428
VERSION     XP_011520428.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522126.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..660
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..660
                     /product="E3 SUMO-protein ligase PIAS1 isoform X1"
                     /calculated_mol_wt=72990
     Region          20..54
                     /region_name="SAP"
                     /note="Putative DNA-binding (bihelical) motif predicted to
                     be involved in chromosomal organisation; smart00513"
                     /db_xref="CDD:128789"
     Region          149..295
                     /region_name="PINIT"
                     /note="PINIT domain; pfam14324"
                     /db_xref="CDD:464136"
     Region          336..395
                     /region_name="SP-RING_PIAS1"
                     /note="SP-RING finger found in protein inhibitor of
                     activated STAT protein 1 (PIAS1) and similar proteins;
                     cd16818"
                     /db_xref="CDD:438467"
     CDS             1..660
                     /gene="PIAS1"
                     /gene_synonym="DDXBP1; GBP; GU/RH-II; ZMIZ3"
                     /coded_by="XM_011522126.3:1090..3072"
                     /db_xref="GeneID:8554"
                     /db_xref="HGNC:HGNC:2752"
                     /db_xref="MIM:603566"
ORIGIN      
        1 mklngkrnhn yksyyecqmv mslrvselqv llgyagrnkh grkhelltka lhllkagcsp
       61 avqmkikely rrrfpqkimt padlsipnvh sspmpatlsp stipqltydg hpasspllpv
      121 sllgpkhele lphltsalhp vhpdiklqkl pfydlldeli kptslasdns qrfretcfaf
      181 altpqqvqqi sssmdisgtk cdftvqvqlr fclsetscpq edhfppnlcv kvntkpcslp
      241 gylpptkngv epkrpsrpin itslvrlstt vpntivvswt aeigrnysma vylvkqlsst
      301 vllqrlrakg irnpdhsral ikekltadpd seiattslrv sllcplgkmr ltipcraltc
      361 shlqcfdatl yiqmnekkpt wvcpvcdkka pyehliidgl fmeilkyctd cdeiqfkedg
      421 twapmrskke vqevsasyng vdgclsstle hqvashhqss nknkkvevid ltidsssdee
      481 eeepsakrtc pslsptspln nkgilslphq aspvsrtpsl pavdtsyint sliqdyrhpf
      541 hmtpmpydlq gldffpflsg dnqhyntsll aaaaaavsdd qdllhssrff pytssqmfld
      601 qlsaggstsl pttngsssgs nsslvssnsl reshshtvtn rsstdtasif giipdiisld
//
LOCUS       XP_016878177             653 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 SUMO-protein ligase PIAS1 isoform X2 [Homo sapiens].
ACCESSION   XP_016878177
VERSION     XP_016878177.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022688.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..653
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..653
                     /product="E3 SUMO-protein ligase PIAS1 isoform X2"
                     /calculated_mol_wt=72073
     Region          13..47
                     /region_name="SAP"
                     /note="Putative DNA-binding (bihelical) motif predicted to
                     be involved in chromosomal organisation; smart00513"
                     /db_xref="CDD:128789"
     Region          142..288
                     /region_name="PINIT"
                     /note="PINIT domain; pfam14324"
                     /db_xref="CDD:464136"
     Region          329..388
                     /region_name="SP-RING_PIAS1"
                     /note="SP-RING finger found in protein inhibitor of
                     activated STAT protein 1 (PIAS1) and similar proteins;
                     cd16818"
                     /db_xref="CDD:438467"
     CDS             1..653
                     /gene="PIAS1"
                     /gene_synonym="DDXBP1; GBP; GU/RH-II; ZMIZ3"
                     /coded_by="XM_017022688.2:1570..3531"
                     /db_xref="GeneID:8554"
                     /db_xref="HGNC:HGNC:2752"
                     /db_xref="MIM:603566"
ORIGIN      
        1 mftlqdsyvk qmvmslrvse lqvllgyagr nkhgrkhell tkalhllkag cspavqmkik
       61 elyrrrfpqk imtpadlsip nvhsspmpat lspstipqlt ydghpasspl lpvsllgpkh
      121 elelphltsa lhpvhpdikl qklpfydlld elikptslas dnsqrfretc fafaltpqqv
      181 qqisssmdis gtkcdftvqv qlrfclsets cpqedhfppn lcvkvntkpc slpgylpptk
      241 ngvepkrpsr pinitslvrl sttvpntivv swtaeigrny smavylvkql sstvllqrlr
      301 akgirnpdhs ralikeklta dpdseiatts lrvsllcplg kmrltipcra ltcshlqcfd
      361 atlyiqmnek kptwvcpvcd kkapyehlii dglfmeilky ctdcdeiqfk edgtwapmrs
      421 kkevqevsas yngvdgclss tlehqvashh qssnknkkve vidltidsss deeeeepsak
      481 rtcpslspts plnnkgilsl phqaspvsrt pslpavdtsy intsliqdyr hpfhmtpmpy
      541 dlqgldffpf lsgdnqhynt sllaaaaaav sddqdllhss rffpytssqm fldqlsaggs
      601 tslpttngss sgsnsslvss nslreshsht vtnrsstdta sifgiipdii sld
//
LOCUS       XP_011520429             645 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 SUMO-protein ligase PIAS1 isoform X3 [Homo sapiens].
ACCESSION   XP_011520429
VERSION     XP_011520429.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522127.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..645
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..645
                     /product="E3 SUMO-protein ligase PIAS1 isoform X3"
                     /calculated_mol_wt=71120
     Region          5..39
                     /region_name="SAP"
                     /note="Putative DNA-binding (bihelical) motif predicted to
                     be involved in chromosomal organisation; smart00513"
                     /db_xref="CDD:128789"
     Region          134..280
                     /region_name="PINIT"
                     /note="PINIT domain; pfam14324"
                     /db_xref="CDD:464136"
     Region          321..380
                     /region_name="SP-RING_PIAS1"
                     /note="SP-RING finger found in protein inhibitor of
                     activated STAT protein 1 (PIAS1) and similar proteins;
                     cd16818"
                     /db_xref="CDD:438467"
     CDS             1..645
                     /gene="PIAS1"
                     /gene_synonym="DDXBP1; GBP; GU/RH-II; ZMIZ3"
                     /coded_by="XM_011522127.3:651..2588"
                     /db_xref="GeneID:8554"
                     /db_xref="HGNC:HGNC:2752"
                     /db_xref="MIM:603566"
ORIGIN      
        1 meqmvmslrv selqvllgya grnkhgrkhe lltkalhllk agcspavqmk ikelyrrrfp
       61 qkimtpadls ipnvhsspmp atlspstipq ltydghpass pllpvsllgp khelelphlt
      121 salhpvhpdi klqklpfydl ldelikptsl asdnsqrfre tcfafaltpq qvqqisssmd
      181 isgtkcdftv qvqlrfclse tscpqedhfp pnlcvkvntk pcslpgylpp tkngvepkrp
      241 srpinitslv rlsttvpnti vvswtaeigr nysmavylvk qlsstvllqr lrakgirnpd
      301 hsralikekl tadpdseiat tslrvsllcp lgkmrltipc raltcshlqc fdatlyiqmn
      361 ekkptwvcpv cdkkapyehl iidglfmeil kyctdcdeiq fkedgtwapm rskkevqevs
      421 asyngvdgcl sstlehqvas hhqssnknkk vevidltids ssdeeeeeps akrtcpslsp
      481 tsplnnkgil slphqaspvs rtpslpavdt syintsliqd yrhpfhmtpm pydlqgldff
      541 pflsgdnqhy ntsllaaaaa avsddqdllh ssrffpytss qmfldqlsag gstslpttng
      601 sssgsnsslv ssnslreshs htvtnrsstd tasifgiipd iisld
//
LOCUS       XP_016878178             644 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 SUMO-protein ligase PIAS1 isoform X4 [Homo sapiens].
ACCESSION   XP_016878178
VERSION     XP_016878178.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022689.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..644
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..644
                     /product="E3 SUMO-protein ligase PIAS1 isoform X4"
                     /calculated_mol_wt=70990
     Region          4..38
                     /region_name="SAP"
                     /note="Putative DNA-binding (bihelical) motif predicted to
                     be involved in chromosomal organisation; smart00513"
                     /db_xref="CDD:128789"
     Region          133..279
                     /region_name="PINIT"
                     /note="PINIT domain; pfam14324"
                     /db_xref="CDD:464136"
     Region          320..379
                     /region_name="SP-RING_PIAS1"
                     /note="SP-RING finger found in protein inhibitor of
                     activated STAT protein 1 (PIAS1) and similar proteins;
                     cd16818"
                     /db_xref="CDD:438467"
     CDS             1..644
                     /gene="PIAS1"
                     /gene_synonym="DDXBP1; GBP; GU/RH-II; ZMIZ3"
                     /coded_by="XM_017022689.2:922..2856"
                     /db_xref="GeneID:8554"
                     /db_xref="HGNC:HGNC:2752"
                     /db_xref="MIM:603566"
ORIGIN      
        1 mqmvmslrvs elqvllgyag rnkhgrkhel ltkalhllka gcspavqmki kelyrrrfpq
       61 kimtpadlsi pnvhsspmpa tlspstipql tydghpassp llpvsllgpk helelphlts
      121 alhpvhpdik lqklpfydll delikptsla sdnsqrfret cfafaltpqq vqqisssmdi
      181 sgtkcdftvq vqlrfclset scpqedhfpp nlcvkvntkp cslpgylppt kngvepkrps
      241 rpinitslvr lsttvpntiv vswtaeigrn ysmavylvkq lsstvllqrl rakgirnpdh
      301 sralikeklt adpdseiatt slrvsllcpl gkmrltipcr altcshlqcf datlyiqmne
      361 kkptwvcpvc dkkapyehli idglfmeilk yctdcdeiqf kedgtwapmr skkevqevsa
      421 syngvdgcls stlehqvash hqssnknkkv evidltidss sdeeeeepsa krtcpslspt
      481 splnnkgils lphqaspvsr tpslpavdts yintsliqdy rhpfhmtpmp ydlqgldffp
      541 flsgdnqhyn tsllaaaaaa vsddqdllhs srffpytssq mfldqlsagg stslpttngs
      601 ssgsnsslvs snslreshsh tvtnrsstdt asifgiipdi isld
//
LOCUS       XP_047289153             467 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 SUMO-protein ligase PIAS1 isoform X5 [Homo sapiens].
ACCESSION   XP_047289153
VERSION     XP_047289153.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433197.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..467
                     /product="E3 SUMO-protein ligase PIAS1 isoform X5"
                     /calculated_mol_wt=51265
     Region          <13..102
                     /region_name="PINIT"
                     /note="PINIT domain; pfam14324"
                     /db_xref="CDD:464136"
     Region          143..202
                     /region_name="SP-RING_PIAS1"
                     /note="SP-RING finger found in protein inhibitor of
                     activated STAT protein 1 (PIAS1) and similar proteins;
                     cd16818"
                     /db_xref="CDD:438467"
     CDS             1..467
                     /gene="PIAS1"
                     /gene_synonym="DDXBP1; GBP; GU/RH-II; ZMIZ3"
                     /coded_by="XM_047433197.1:130..1533"
                     /db_xref="GeneID:8554"
                     /db_xref="HGNC:HGNC:2752"
                     /db_xref="MIM:603566"
ORIGIN      
        1 mdisgtkcdf tvqvqlrfcl setscpqedh fppnlcvkvn tkpcslpgyl pptkngvepk
       61 rpsrpinits lvrlsttvpn tivvswtaei grnysmavyl vkqlsstvll qrlrakgirn
      121 pdhsralike kltadpdsei attslrvsll cplgkmrlti pcraltcshl qcfdatlyiq
      181 mnekkptwvc pvcdkkapye hliidglfme ilkyctdcde iqfkedgtwa pmrskkevqe
      241 vsasyngvdg clsstlehqv ashhqssnkn kkvevidlti dsssdeeeee psakrtcpsl
      301 sptsplnnkg ilslphqasp vsrtpslpav dtsyintsli qdyrhpfhmt pmpydlqgld
      361 ffpflsgdnq hyntsllaaa aaavsddqdl lhssrffpyt ssqmfldqls aggstslptt
      421 ngsssgsnss lvssnslres hshtvtnrss tdtasifgii pdiisld
//
LOCUS       XP_006720788             222 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptosomal-associated protein 23 isoform X1 [Homo sapiens].
ACCESSION   XP_006720788
VERSION     XP_006720788.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720725.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..222
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..222
                     /product="synaptosomal-associated protein 23 isoform X1"
                     /calculated_mol_wt=24528
     Region          9..75
                     /region_name="SNARE_SNAP23N"
                     /note="N-terminal SNARE motif of SNAP23; cd15895"
                     /db_xref="CDD:277248"
     Site            order(13,16..21,23..28,30..31,34..35,37..42,44..45,47..49,
                     51..56,58..59,61..63,65..66,68..70,72..73,75)
                     /site_type="other"
                     /note="heterotetramer interface [polypeptide binding]"
                     /db_xref="CDD:277248"
     Site            48
                     /site_type="active"
                     /note="zero layer [active]"
                     /db_xref="CDD:277248"
     Region          100..159
                     /region_name="SNAP-25"
                     /note="SNAP-25 family; pfam00835"
                     /db_xref="CDD:459955"
     Region          160..218
                     /region_name="SNARE_SNAP23C"
                     /note="C-terminal SNARE motif of SNAP23; cd15884"
                     /db_xref="CDD:277237"
     Site            order(160,162..163,166..171,173..174,177..178,180..182,
                     184..185,188..189,191..192,194..199,201..202,205,208,212,
                     215,218)
                     /site_type="other"
                     /note="heterotetramer interface [polypeptide binding]"
                     /db_xref="CDD:277237"
     Site            191
                     /site_type="other"
                     /note="zero layer"
                     /db_xref="CDD:277237"
     CDS             1..222
                     /gene="SNAP23"
                     /gene_synonym="HsT17016; SNAP-23; SNAP23A; SNAP23B"
                     /coded_by="XM_006720725.4:95..763"
                     /db_xref="GeneID:8773"
                     /db_xref="HGNC:HGNC:11131"
                     /db_xref="MIM:602534"
ORIGIN      
        1 mdnlsseeiq qrahqitdes lestrrilgl aiesqdagik titmldeqke qlnrieegld
       61 qinkdmrete ktltelnkcc glcvcpcnrf sdvgcfyetr tknfesgkay kttwgdggen
      121 spcnvvskqp gpvtngqlqq pttgaasggy ikritndare demeenltqv gsilgnlkdm
      181 alnigneida qnpqikritd kadtnrdrid ianarakkli ds
//
LOCUS       XP_047289155             222 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptosomal-associated protein 23 isoform X1 [Homo sapiens].
ACCESSION   XP_047289155
VERSION     XP_047289155.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433199.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..222
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..222
                     /product="synaptosomal-associated protein 23 isoform X1"
                     /calculated_mol_wt=24528
     Region          9..75
                     /region_name="SNARE_SNAP23N"
                     /note="N-terminal SNARE motif of SNAP23; cd15895"
                     /db_xref="CDD:277248"
     Site            order(13,16..21,23..28,30..31,34..35,37..42,44..45,47..49,
                     51..56,58..59,61..63,65..66,68..70,72..73,75)
                     /site_type="other"
                     /note="heterotetramer interface [polypeptide binding]"
                     /db_xref="CDD:277248"
     Site            48
                     /site_type="active"
                     /note="zero layer [active]"
                     /db_xref="CDD:277248"
     Region          100..159
                     /region_name="SNAP-25"
                     /note="SNAP-25 family; pfam00835"
                     /db_xref="CDD:459955"
     Region          160..218
                     /region_name="SNARE_SNAP23C"
                     /note="C-terminal SNARE motif of SNAP23; cd15884"
                     /db_xref="CDD:277237"
     Site            order(160,162..163,166..171,173..174,177..178,180..182,
                     184..185,188..189,191..192,194..199,201..202,205,208,212,
                     215,218)
                     /site_type="other"
                     /note="heterotetramer interface [polypeptide binding]"
                     /db_xref="CDD:277237"
     Site            191
                     /site_type="other"
                     /note="zero layer"
                     /db_xref="CDD:277237"
     CDS             1..222
                     /gene="SNAP23"
                     /gene_synonym="HsT17016; SNAP-23; SNAP23A; SNAP23B"
                     /coded_by="XM_047433199.1:414..1082"
                     /db_xref="GeneID:8773"
                     /db_xref="HGNC:HGNC:11131"
                     /db_xref="MIM:602534"
ORIGIN      
        1 mdnlsseeiq qrahqitdes lestrrilgl aiesqdagik titmldeqke qlnrieegld
       61 qinkdmrete ktltelnkcc glcvcpcnrf sdvgcfyetr tknfesgkay kttwgdggen
      121 spcnvvskqp gpvtngqlqq pttgaasggy ikritndare demeenltqv gsilgnlkdm
      181 alnigneida qnpqikritd kadtnrdrid ianarakkli ds
//
LOCUS       XP_047289156             222 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptosomal-associated protein 23 isoform X1 [Homo sapiens].
ACCESSION   XP_047289156
VERSION     XP_047289156.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433200.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..222
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..222
                     /product="synaptosomal-associated protein 23 isoform X1"
                     /calculated_mol_wt=24528
     Region          9..75
                     /region_name="SNARE_SNAP23N"
                     /note="N-terminal SNARE motif of SNAP23; cd15895"
                     /db_xref="CDD:277248"
     Site            order(13,16..21,23..28,30..31,34..35,37..42,44..45,47..49,
                     51..56,58..59,61..63,65..66,68..70,72..73,75)
                     /site_type="other"
                     /note="heterotetramer interface [polypeptide binding]"
                     /db_xref="CDD:277248"
     Site            48
                     /site_type="active"
                     /note="zero layer [active]"
                     /db_xref="CDD:277248"
     Region          100..159
                     /region_name="SNAP-25"
                     /note="SNAP-25 family; pfam00835"
                     /db_xref="CDD:459955"
     Region          160..218
                     /region_name="SNARE_SNAP23C"
                     /note="C-terminal SNARE motif of SNAP23; cd15884"
                     /db_xref="CDD:277237"
     Site            order(160,162..163,166..171,173..174,177..178,180..182,
                     184..185,188..189,191..192,194..199,201..202,205,208,212,
                     215,218)
                     /site_type="other"
                     /note="heterotetramer interface [polypeptide binding]"
                     /db_xref="CDD:277237"
     Site            191
                     /site_type="other"
                     /note="zero layer"
                     /db_xref="CDD:277237"
     CDS             1..222
                     /gene="SNAP23"
                     /gene_synonym="HsT17016; SNAP-23; SNAP23A; SNAP23B"
                     /coded_by="XM_047433200.1:119..787"
                     /db_xref="GeneID:8773"
                     /db_xref="HGNC:HGNC:11131"
                     /db_xref="MIM:602534"
ORIGIN      
        1 mdnlsseeiq qrahqitdes lestrrilgl aiesqdagik titmldeqke qlnrieegld
       61 qinkdmrete ktltelnkcc glcvcpcnrf sdvgcfyetr tknfesgkay kttwgdggen
      121 spcnvvskqp gpvtngqlqq pttgaasggy ikritndare demeenltqv gsilgnlkdm
      181 alnigneida qnpqikritd kadtnrdrid ianarakkli ds
//
LOCUS       XP_047289158             211 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptosomal-associated protein 23 isoform X2 [Homo sapiens].
ACCESSION   XP_047289158
VERSION     XP_047289158.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433202.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..211
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..211
                     /product="synaptosomal-associated protein 23 isoform X2"
                     /calculated_mol_wt=23223
     Region          9..75
                     /region_name="SNARE_SNAP23N"
                     /note="N-terminal SNARE motif of SNAP23; cd15895"
                     /db_xref="CDD:277248"
     Site            order(13,16..21,23..28,30..31,34..35,37..42,44..45,47..49,
                     51..56,58..59,61..63,65..66,68..70,72..73,75)
                     /site_type="other"
                     /note="heterotetramer interface [polypeptide binding]"
                     /db_xref="CDD:277248"
     Site            48
                     /site_type="active"
                     /note="zero layer [active]"
                     /db_xref="CDD:277248"
     Region          86..148
                     /region_name="SNAP-25"
                     /note="SNAP-25 family; pfam00835"
                     /db_xref="CDD:459955"
     Region          149..207
                     /region_name="SNARE_SNAP23C"
                     /note="C-terminal SNARE motif of SNAP23; cd15884"
                     /db_xref="CDD:277237"
     Site            order(149,151..152,155..160,162..163,166..167,169..171,
                     173..174,177..178,180..181,183..188,190..191,194,197,201,
                     204,207)
                     /site_type="other"
                     /note="heterotetramer interface [polypeptide binding]"
                     /db_xref="CDD:277237"
     Site            180
                     /site_type="other"
                     /note="zero layer"
                     /db_xref="CDD:277237"
     CDS             1..211
                     /gene="SNAP23"
                     /gene_synonym="HsT17016; SNAP-23; SNAP23A; SNAP23B"
                     /coded_by="XM_047433202.1:424..1059"
                     /db_xref="GeneID:8773"
                     /db_xref="HGNC:HGNC:11131"
                     /db_xref="MIM:602534"
ORIGIN      
        1 mdnlsseeiq qrahqitdes lestrrilgl aiesqdagik titmldeqke qlnrieegld
       61 qinkdmrete ktltelnkcc glcvcpcnrt knfesgkayk ttwgdggens pcnvvskqpg
      121 pvtngqlqqp ttgaasggyi kritndared emeenltqvg silgnlkdma lnigneidaq
      181 npqikritdk adtnrdridi anarakklid s
//
LOCUS       XP_016878183             211 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptosomal-associated protein 23 isoform X2 [Homo sapiens].
ACCESSION   XP_016878183
VERSION     XP_016878183.2
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022694.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XP_016878183.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..211
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..211
                     /product="synaptosomal-associated protein 23 isoform X2"
                     /calculated_mol_wt=23223
     Region          9..75
                     /region_name="SNARE_SNAP23N"
                     /note="N-terminal SNARE motif of SNAP23; cd15895"
                     /db_xref="CDD:277248"
     Site            order(13,16..21,23..28,30..31,34..35,37..42,44..45,47..49,
                     51..56,58..59,61..63,65..66,68..70,72..73,75)
                     /site_type="other"
                     /note="heterotetramer interface [polypeptide binding]"
                     /db_xref="CDD:277248"
     Site            48
                     /site_type="active"
                     /note="zero layer [active]"
                     /db_xref="CDD:277248"
     Region          86..148
                     /region_name="SNAP-25"
                     /note="SNAP-25 family; pfam00835"
                     /db_xref="CDD:459955"
     Region          149..207
                     /region_name="SNARE_SNAP23C"
                     /note="C-terminal SNARE motif of SNAP23; cd15884"
                     /db_xref="CDD:277237"
     Site            order(149,151..152,155..160,162..163,166..167,169..171,
                     173..174,177..178,180..181,183..188,190..191,194,197,201,
                     204,207)
                     /site_type="other"
                     /note="heterotetramer interface [polypeptide binding]"
                     /db_xref="CDD:277237"
     Site            180
                     /site_type="other"
                     /note="zero layer"
                     /db_xref="CDD:277237"
     CDS             1..211
                     /gene="SNAP23"
                     /gene_synonym="HsT17016; SNAP-23; SNAP23A; SNAP23B"
                     /coded_by="XM_017022694.2:199..834"
                     /db_xref="GeneID:8773"
                     /db_xref="HGNC:HGNC:11131"
                     /db_xref="MIM:602534"
ORIGIN      
        1 mdnlsseeiq qrahqitdes lestrrilgl aiesqdagik titmldeqke qlnrieegld
       61 qinkdmrete ktltelnkcc glcvcpcnrt knfesgkayk ttwgdggens pcnvvskqpg
      121 pvtngqlqqp ttgaasggyi kritndared emeenltqvg silgnlkdma lnigneidaq
      181 npqikritdk adtnrdridi anarakklid s
//
LOCUS       XP_047289159             211 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptosomal-associated protein 23 isoform X2 [Homo sapiens].
ACCESSION   XP_047289159
VERSION     XP_047289159.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433203.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..211
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..211
                     /product="synaptosomal-associated protein 23 isoform X2"
                     /calculated_mol_wt=23223
     Region          9..75
                     /region_name="SNARE_SNAP23N"
                     /note="N-terminal SNARE motif of SNAP23; cd15895"
                     /db_xref="CDD:277248"
     Site            order(13,16..21,23..28,30..31,34..35,37..42,44..45,47..49,
                     51..56,58..59,61..63,65..66,68..70,72..73,75)
                     /site_type="other"
                     /note="heterotetramer interface [polypeptide binding]"
                     /db_xref="CDD:277248"
     Site            48
                     /site_type="active"
                     /note="zero layer [active]"
                     /db_xref="CDD:277248"
     Region          86..148
                     /region_name="SNAP-25"
                     /note="SNAP-25 family; pfam00835"
                     /db_xref="CDD:459955"
     Region          149..207
                     /region_name="SNARE_SNAP23C"
                     /note="C-terminal SNARE motif of SNAP23; cd15884"
                     /db_xref="CDD:277237"
     Site            order(149,151..152,155..160,162..163,166..167,169..171,
                     173..174,177..178,180..181,183..188,190..191,194,197,201,
                     204,207)
                     /site_type="other"
                     /note="heterotetramer interface [polypeptide binding]"
                     /db_xref="CDD:277237"
     Site            180
                     /site_type="other"
                     /note="zero layer"
                     /db_xref="CDD:277237"
     CDS             1..211
                     /gene="SNAP23"
                     /gene_synonym="HsT17016; SNAP-23; SNAP23A; SNAP23B"
                     /coded_by="XM_047433203.1:267..902"
                     /db_xref="GeneID:8773"
                     /db_xref="HGNC:HGNC:11131"
                     /db_xref="MIM:602534"
ORIGIN      
        1 mdnlsseeiq qrahqitdes lestrrilgl aiesqdagik titmldeqke qlnrieegld
       61 qinkdmrete ktltelnkcc glcvcpcnrt knfesgkayk ttwgdggens pcnvvskqpg
      121 pvtngqlqqp ttgaasggyi kritndared emeenltqvg silgnlkdma lnigneidaq
      181 npqikritdk adtnrdridi anarakklid s
//
LOCUS       XP_047289160            1191 aa            linear   PRI 05-AUG-2025
DEFINITION  ras GTPase-activating-like protein IQGAP1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_047289160
VERSION     XP_047289160.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433204.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1191
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1191
                     /product="ras GTPase-activating-like protein IQGAP1
                     isoform X1"
                     /calculated_mol_wt=135873
     Region          37..190
                     /region_name="CH_IQGAP1"
                     /note="calponin homology (CH) domain found in Ras
                     GTPase-activating-like protein IQGAP1; cd21274"
                     /db_xref="CDD:409123"
     Site            order(46,50,111,113..114,117..118,120,130..138,144,
                     146..147,149..150,153..154,157)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409123"
     Region          685..710
                     /region_name="WW"
                     /note="Two conserved tryptophans domain; also known as the
                     WWP or rsp5 domain; around 40 amino acids; functions as an
                     interaction module in a diverse set of signalling
                     proteins; binds specific proline-rich sequences but at low
                     affinities compared to other...; cd00201"
                     /db_xref="CDD:238122"
     Site            order(696,707)
                     /site_type="active"
                     /note="binding pocket [active]"
                     /db_xref="CDD:238122"
     Region          <749..>954
                     /region_name="IQG1"
                     /note="Protein involved in regulation of cellular
                     morphogenesis/cytokinesis [Cell division and chromosome
                     partitioning / Signal transduction mechanisms]; COG5261"
                     /db_xref="CDD:227586"
     Region          1003..>1185
                     /region_name="RasGAP"
                     /note="Ras GTPase Activating Domain; cl02569"
                     /db_xref="CDD:470620"
     CDS             1..1191
                     /gene="IQGAP1"
                     /gene_synonym="HUMORFA01; p195; SAR1"
                     /coded_by="XM_047433204.1:101..3676"
                     /db_xref="GeneID:8826"
                     /db_xref="HGNC:HGNC:6110"
                     /db_xref="MIM:603379"
ORIGIN      
        1 msaadevdgl gvarphygsv ldnerltaee mderrrqnva yeylchleea krwmeaclge
       61 dlppttelee glrngvylak lgnffspkvv slkkiydreq trykatglhf rhtdnviqwl
      121 namdeiglpk ifypettdiy drknmprciy cihalslylf klglapqiqd lygkvdftee
      181 einnmktele kygiqmpafs kiggilanel svdeaalhaa viaineaidr ripadtfaal
      241 knpnamlvnl eeplastyqd ilyqakqdkm tnaknrtens ererdvyeel ltqaeiqgni
      301 nkvntfsala nidlaleqgd alalfralqs palglrglqq qnsdwylkql lsdkqqkrqs
      361 gqtdplqkee lqsgvdaans aaqqyqrrla avalinaaiq kgvaektvle lmnpeaqlpq
      421 vypfaadlyq kelatlqrqs pehnlthpel svavemlssv alinralesg dvntvwkqls
      481 ssvtgltnie eencqrylde lmklkaqaha ennefitwnd iqacvdhvnl vvqeeheril
      541 aiglineald egdaqktlqa lqipaakleg vlaevaqhyq dtlirakrek aqeiqdesav
      601 lwldeiqggi wqsnkdtqea qkfalgifai neavesgdvg ktlsalrspd vglygvipec
      661 getyhsdlae akkkklavgd nnskwvkhwv kggyyyyhnl etqeggwdep pnfvqnsmql
      721 sreeiqssis gvtaaynreq lwlaneglit rlqarcrgyl vrqefrsrmn flkkqipait
      781 ciqsqwrgyk qkkayqdrla ylrshkdevv kiqslarmhq arkryrdrlq yfrdhindii
      841 kiqafirank arddyktlin aedppmvvvr kfvhlldqsd qdfqeeldlm kmreevitli
      901 rsnqqlendl nlmdikigll vknkitlqdv vshskkltkk nkeqlsdmmm inkqkgglka
      961 lskekrekle ayqhlfyllq tnptylakli fqmpqnkstk fmdsviftly nyasnqreey
     1021 lllrlfktal qeeikskvdq iqeivtgnpt vikmvvsfnr gargqnalrq ilapvvkeim
     1081 ddkslniktd pvdiykswvn qmesqtgeas klpydvtpeq alaheevktr ldssirnmra
     1141 vtdkflsaiv ssvdkipygm rfiakvlkds lhekfpdage dellkfcafl q
//
LOCUS       XP_006720789            4829 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase HERC2 isoform X1 [Homo sapiens].
ACCESSION   XP_006720789
VERSION     XP_006720789.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720726.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4829
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4829
                     /product="E3 ubiquitin-protein ligase HERC2 isoform X1"
                     /calculated_mol_wt=526488
     Region          454..775
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          1206..1277
                     /region_name="Cyt-b5"
                     /note="Cytochrome b5-like Heme/Steroid binding domain;
                     pfam00173"
                     /db_xref="CDD:459698"
     Region          1865..1925
                     /region_name="MIB_HERC2"
                     /note="Mib_herc2; pfam06701"
                     /db_xref="CDD:461991"
     Region          2455..2502
                     /region_name="UBA_HERC2"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC2 and similar proteins; cd14402"
                     /db_xref="CDD:270585"
     Region          2549..2626
                     /region_name="Cul7"
                     /note="Mouse development and cellular proliferation
                     protein Cullin-7; pfam11515"
                     /db_xref="CDD:463286"
     Region          2634..2691
                     /region_name="SH3_15"
                     /note="Mind bomb SH3 repeat domain; pfam18346"
                     /db_xref="CDD:465720"
     Region          2701..2745
                     /region_name="ZZ_HERC2"
                     /note="Zinc finger, ZZ type. Zinc finger present in HERC2
                     and related proteins. HERC2 is a potential E3 ubiquitin
                     protein ligase and/or guanine nucleotide exchange factor.
                     The ZZ motif coordinates two zinc ions and most likely
                     participates in ligand binding or...; cd02344"
                     /db_xref="CDD:239084"
     Site            order(2703,2706,2718,2721,2727,2730,2736,2740)
                     /site_type="other"
                     /note="Zinc-binding sites [ion binding]"
                     /db_xref="CDD:239084"
     Site            order(2703,2706,2727,2730)
                     /site_type="other"
                     /note="zinc cluster 1 [ion binding]"
                     /db_xref="CDD:239084"
     Site            order(2704,2715,2717,2723,2725)
                     /site_type="active"
                     /note="putative charged binding surface [active]"
                     /db_xref="CDD:239084"
     Site            order(2716,2731,2742,2745)
                     /site_type="active"
                     /note="putative hydrophobic binding surface [active]"
                     /db_xref="CDD:239084"
     Site            order(2718,2721,2736,2740)
                     /site_type="other"
                     /note="zinc cluster 2 [ion binding]"
                     /db_xref="CDD:239084"
     Region          2760..2905
                     /region_name="APC10-HERC2"
                     /note="APC10-like DOC1 domain present in HERC2 (HECT
                     domain and RLD2); cd08664"
                     /db_xref="CDD:176485"
     Site            order(2803,2831,2837,2839,2898)
                     /site_type="other"
                     /note="putative ligand binding site [chemical binding]"
                     /db_xref="CDD:176485"
     Region          2943..3296
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          3939..4287
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          4416..4787
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4422,4468,4479,4546,4717,4751..4752,4755..4759,4779,
                     4786)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4574,4577..4578,4580..4581,4584,4591,4594..4595,
                     4597,4603,4608,4625,4629)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4829
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /coded_by="XM_006720726.4:137..14626"
                     /db_xref="GeneID:8924"
                     /db_xref="HGNC:HGNC:4868"
                     /db_xref="MIM:605837"
ORIGIN      
        1 mpsesfclaa qarldskwlk tdiqlaftrd glcglwnemv kdgeivytgt estqngelpp
       61 rkddsvepsg tkkedlndke kkdeeetpap iyraksilds wvwgkqpdvn elkeclsvlv
      121 keqqalavqs atttlsalrl kqrlvilery fialnrtvfq envkvkwkss gislppvdkk
      181 ssrpagkgve glarvgsraa lsfafaflrr awrsgedadl csellqesld alralpeasl
      241 fdestvssvw levveratrf lrsvvtgdvh gtpatkgpgs iplqdqhlal aillelavqr
      301 gtlsqmlsai llllqlwdsg aqetdnersa qgtsapllpl lqrfqsiicr kdaphsegdm
      361 hllsgplspn esflryltlp qdnelaidlr qtavvvmahl drlatpcmpp lcssptshkg
      421 slqevigwgl igwkyyanvi gpiqceglan lgvtqiacae krflilsrng rvytqaynsd
      481 tlapqlvqgl asrnivkiaa hsdghhylal aatgevyswg cgdggrlghg dtvpleepkv
      541 isafsgkqag khvvhiacgs tysaaitaeg elytwgrgny grlghgssed eaipmlvagl
      601 kglkvidvac gsgdaqtlav tengqvwswg dgdygklgrg gsdgcktpkl ieklqdldvv
      661 kvrcgsqfsi altkdgqvys wgkgdnqrlg hgteehvryp klleglqgkk vidvaagsth
      721 claltedsev hswgsndqcq hfdtlrvtkp epaalpgldt khivgiacgp aqsfawsscs
      781 ewsiglrvpf vvdicsmtfe qldlllrqvs egmdgsadwp ppqekecvav atlnllrlql
      841 haaishqvdp eflglglgsi llnslkqtvv tlassagvls tvqsaaqavl qsgwsvllpt
      901 aeeraralsa llpcavsgne vnispgrrfm idllvgslma dgglesalha aitaeiqdie
      961 akkeaqkeke ideqeanast fhrsrtpldk dlintgices sgkqclplvq liqqllrnia
     1021 sqtvarlkdv arrisscldf eqhsrersas ldlllrfqrl lisklypges igqtsdissp
     1081 elmgvgsllk kytallcthi gdilpvaasi astswrhfae vayivegdft gvllpelvvs
     1141 ivlllsknag lmqeagavpl lggllehldr fnhlapgker ddheelawpg imgqncrnne
     1201 evtlirkadl enhnkdggfw tvidgkvydi kdfqtqsltg nsilaqfage dpvvaleaal
     1261 qfedtresmh afcvgqylep dqeivtipdl gslssplidt ernlglllgl hasylamstp
     1321 lspveiecak wlqssifsgg lqtsqihysy neekdedhcs spggtpasks rlcshrralg
     1381 dhsqaflqai adnniqdhnv kdflcqiery crqchlttpi mfppehpvee vgrlllccll
     1441 khedlghval slvhagalgi eqvkhrtlpk svvdvcrvvy qakcslikth qeqgrsykev
     1501 capvierlrf lfnelrpavc ndlsimskfk llsslprwrr iaqkiirerr kkrvpkkpes
     1561 tddeekigne esdleeacil phspinvdkr piaikspkdk wqpllstvtg vhkykwlkqn
     1621 vqglypqspl lstiaefalk eepvdvekmr kcllkqlera evrlegidti lklasknfll
     1681 psvqyamfcg wqrlipegid igepltdclk dvdlippfnr mllevtfgkl yawavqnirn
     1741 vlmdasakfk elgiqpvplq titnenpsgp slgtipqarf llvmlsmltl qhgannldll
     1801 lnsgmlaltq talrligpsc dnveedmnas aqgasatvle etrketapvq lpvsgpelaa
     1861 mmkigtrvmr gvdwkwgdqd gpppglgrvi gelgedgwir vqwdtgstns yrmgkegkyd
     1921 lklaelpaaa qpsaedsdte ddseaeqter nihptammft stinllqtlc lsagvhaeim
     1981 qseatktlcg llrmlvesgt tdktsspnrl vyreqhrswc tlgfvrsial tpqvcgalss
     2041 pqwitllmkv veghapftat slqrqilavh llqavlpswd kterardmkc lveklfdflg
     2101 sllttcssdv pllrestlrr rrvrpqaslt athsstlaee vvallrtlhs ltqwnglink
     2161 yinsqlrsit hsfvgrpseg aqledyfpds enpevgglma vlaviggidg rlrlggqvmh
     2221 defgegtvtr itpkgkitvq fsdmrtcrvc plnqlkplpa vafnvnnlpf tepmlsvwaq
     2281 lvnlagskle khkikkstkq afagqvdldl lrcqqlklyi lkagrallsh qdklrqilsq
     2341 pavqetgtvh tddgavvspd lgdmspegpq ppmillqqll asatqpspvk aifdkqelea
     2401 aalavcqcla vesthpsspg fedcssseat tpvavqhirp arvkrrkqsp vpalpivvql
     2461 memgfsrrni efalksltga sgnasslpgv ealvgwlldh sdiqvtelsd adtvsdeysd
     2521 eevvedvdda aysmstgavv tesqtykkra dflsnddyav yvreniqvgm mvrccrayee
     2581 vcegdvgkvi kldrdglhdl nvqcdwqqkg gtywvryihv eligypppss sshikigdkv
     2641 rvkasvttpk ykwgsvthqs vgvvkafsan gkdiivdfpq qshwtgllse melvpsihpg
     2701 vtcdgcqmfp ingsrfkcrn cddfdfcetc fktkkhntrh tfgrinepgq savfcgrsgk
     2761 qlkrchssqp gmlldswsrm vkslnvsssv nqasrlidgs epcwqssgsq gkhwirleif
     2821 pdvlvhrlkm ivdpadssym pslvvvsggn slnnlielkt ininpsdttv pllndcteyh
     2881 ryieiaikqc rssgidckih glillgrira eeedlaavpf lasdneeeed ekgnsgslir
     2941 kkaaglesaa tirtkvfvwg lndkdqlggl kgskikvpsf setlsalnvv qvaggskslf
     3001 avtvegkvya cgeatngrlg lgissgtvpi prqitalssy vvkkvavhsg grhataltvd
     3061 gkvfswgegd dgklghfsrm ncdkprliea lktkrirdia cgsshsaalt ssgelytwgl
     3121 geygrlghgd nttqlkpkmv kvllghrviq vacgsrdaqt laltdeglvf swgdgdfgkl
     3181 grggsegcni pqnierlngq gvcqiecgaq fslaltksgv vwtwgkgdyf rlghgsdvhv
     3241 rkpqvveglr gkkivhvavg alhclavtds gqvyawgdnd hgqqgngttt vnrkptlvqg
     3301 legqkitrva cgsshsvawt tvdvatpsvh epvlfqtard plgasylgvp sdadssaasn
     3361 kisgasnskp nrpslakill sldgnlakqq alshiltalq imyardavvg almpaamiap
     3421 vecpsfssaa psdasamasp mngeecmlav diedrlspnp wqekreivss edavtpsavt
     3481 psapsasarp fipvtddlga asiiaetmtk tkedvesqnk aagpepqald eftslliadd
     3541 trvvvdllkl svcsragdrg rdvlsavlsg mgtaypqvad mllelcvtel edvatdsqsg
     3601 rlssqpvvve sshpytddts tsgtvkipga eglrvefdrq csterrhdpl tvmdgvnriv
     3661 svrsgrewsd wsselripgd elkwkfisdg svngwgwrft vypimpaagp kellsdrcvl
     3721 scpsmdlvtc lldfrlnlas nrsivprlaa slaacaqlsa laashrmwal qrlrklltte
     3781 fgqsininrl lgendgetra lsftgsalaa lvkglpealq rqfeyedpiv rggkqllhsp
     3841 ffkvlvalac dleldtlpcc aethkwawfr rycmasrvav aldkrtplpr lfldevakki
     3901 relmadsenm dvlheshdif kreqdeqlvq wmnrrpddwt lsaggsgtiy gwghnhrgql
     3961 ggiegakvkv ptpcealatl rpvqliggeq tlfavtadgk lyatgygagg rlgiggtesv
     4021 stptllesiq hvfikkvavn sggkhclals segevyswge aedgklghgn rspcdrprvi
     4081 eslrgievvd vaaggahsac vtaagdlytw gkgrygrlgh sdsedqlkpk lvealqghrv
     4141 vdiacgsgda qtlcltdddt vwswgdgdyg klgrggsdgc kvpmkidslt glgvvkvecg
     4201 sqfsvaltks gavytwgkgd yhrlghgsdd hvrrprqvqg lqgkkviaia tgslhcvcct
     4261 edgevytwgd ndegqlgdgt tnaiqrprlv aalqgkkvnr vacgsahtla wstskpasag
     4321 klpaqvpmey nhlqeipiia lrnrllllhh lselfcpcip mfdlegslde tglgpsvgfd
     4381 tlrgilisqg keaafrkvvq atmvrdrqhg pvvelnriqv krsrskggla gpdgtksvfg
     4441 qmcakmssfg pdslllphrv wkvkfvgesv ddcgggyses iaeiceelqn gltpllivtp
     4501 ngrdesganr dcyllspaar apvhssmfrf lgvllgiair tgsplslnla epvwkqlagm
     4561 sltiadlsev dkdfipglmy irdneatsee feamslpftv psasgqdiql sskhthitld
     4621 nraeyvrlai nyrlhefdeq vaavregmar vvpvpllslf tgyeletmvc gspdiplhll
     4681 ksvatykgie psasliqwfw evmesfsnte rslflrfvwg rtrlprtiad frgrdfviqv
     4741 ldkynppdhf lpesytcffl lklprysckq vleeklkyai hfcksidtdd yarialtgep
     4801 aaddssddsd nedvdsfasd stqdyltgh
//
LOCUS       XP_047289162            4825 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase HERC2 isoform X2 [Homo sapiens].
ACCESSION   XP_047289162
VERSION     XP_047289162.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433206.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4825
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4825
                     /product="E3 ubiquitin-protein ligase HERC2 isoform X2"
                     /calculated_mol_wt=526119
     Region          445..766
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          1202..1273
                     /region_name="Cyt-b5"
                     /note="Cytochrome b5-like Heme/Steroid binding domain;
                     pfam00173"
                     /db_xref="CDD:459698"
     Region          1861..1921
                     /region_name="MIB_HERC2"
                     /note="Mib_herc2; pfam06701"
                     /db_xref="CDD:461991"
     Region          2451..2498
                     /region_name="UBA_HERC2"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC2 and similar proteins; cd14402"
                     /db_xref="CDD:270585"
     Region          2545..2622
                     /region_name="Cul7"
                     /note="Mouse development and cellular proliferation
                     protein Cullin-7; pfam11515"
                     /db_xref="CDD:463286"
     Region          2630..2687
                     /region_name="SH3_15"
                     /note="Mind bomb SH3 repeat domain; pfam18346"
                     /db_xref="CDD:465720"
     Region          2697..2741
                     /region_name="ZZ_HERC2"
                     /note="Zinc finger, ZZ type. Zinc finger present in HERC2
                     and related proteins. HERC2 is a potential E3 ubiquitin
                     protein ligase and/or guanine nucleotide exchange factor.
                     The ZZ motif coordinates two zinc ions and most likely
                     participates in ligand binding or...; cd02344"
                     /db_xref="CDD:239084"
     Site            order(2699,2702,2714,2717,2723,2726,2732,2736)
                     /site_type="other"
                     /note="Zinc-binding sites [ion binding]"
                     /db_xref="CDD:239084"
     Site            order(2699,2702,2723,2726)
                     /site_type="other"
                     /note="zinc cluster 1 [ion binding]"
                     /db_xref="CDD:239084"
     Site            order(2700,2711,2713,2719,2721)
                     /site_type="active"
                     /note="putative charged binding surface [active]"
                     /db_xref="CDD:239084"
     Site            order(2712,2727,2738,2741)
                     /site_type="active"
                     /note="putative hydrophobic binding surface [active]"
                     /db_xref="CDD:239084"
     Site            order(2714,2717,2732,2736)
                     /site_type="other"
                     /note="zinc cluster 2 [ion binding]"
                     /db_xref="CDD:239084"
     Region          2756..2901
                     /region_name="APC10-HERC2"
                     /note="APC10-like DOC1 domain present in HERC2 (HECT
                     domain and RLD2); cd08664"
                     /db_xref="CDD:176485"
     Site            order(2799,2827,2833,2835,2894)
                     /site_type="other"
                     /note="putative ligand binding site [chemical binding]"
                     /db_xref="CDD:176485"
     Region          2939..3292
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          3935..4283
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          4412..4783
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4418,4464,4475,4542,4713,4747..4748,4751..4755,4775,
                     4782)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4570,4573..4574,4576..4577,4580,4587,4590..4591,
                     4593,4599,4604,4621,4625)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4825
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /coded_by="XM_047433206.1:7..14484"
                     /db_xref="GeneID:8924"
                     /db_xref="HGNC:HGNC:4868"
                     /db_xref="MIM:605837"
ORIGIN      
        1 mtsmshlarp rvifllaftr dglcglwnem vkdgeivytg testqngelp prkddsveps
       61 gtkkedlndk ekkdeeetpa piyraksild swvwgkqpdv nelkeclsvl vkeqqalavq
      121 satttlsalr lkqrlviler yfialnrtvf qenvkvkwks sgislppvdk kssrpagkgv
      181 eglarvgsra alsfafaflr rawrsgedad lcsellqesl dalralpeas lfdestvssv
      241 wlevveratr flrsvvtgdv hgtpatkgpg siplqdqhla laillelavq rgtlsqmlsa
      301 illllqlwds gaqetdners aqgtsapllp llqrfqsiic rkdaphsegd mhllsgplsp
      361 nesflryltl pqdnelaidl rqtavvvmah ldrlatpcmp plcssptshk gslqevigwg
      421 ligwkyyanv igpiqcegla nlgvtqiaca ekrflilsrn grvytqayns dtlapqlvqg
      481 lasrnivkia ahsdghhyla laatgevysw gcgdggrlgh gdtvpleepk visafsgkqa
      541 gkhvvhiacg stysaaitae gelytwgrgn ygrlghgsse deaipmlvag lkglkvidva
      601 cgsgdaqtla vtengqvwsw gdgdygklgr ggsdgcktpk lieklqdldv vkvrcgsqfs
      661 ialtkdgqvy swgkgdnqrl ghgteehvry pklleglqgk kvidvaagst hclaltedse
      721 vhswgsndqc qhfdtlrvtk pepaalpgld tkhivgiacg paqsfawssc sewsiglrvp
      781 fvvdicsmtf eqldlllrqv segmdgsadw pppqekecva vatlnllrlq lhaaishqvd
      841 peflglglgs illnslkqtv vtlassagvl stvqsaaqav lqsgwsvllp taeerarals
      901 allpcavsgn evnispgrrf midllvgslm adgglesalh aaitaeiqdi eakkeaqkek
      961 eideqeanas tfhrsrtpld kdlintgice ssgkqclplv qliqqllrni asqtvarlkd
     1021 varrisscld feqhsrersa sldlllrfqr llisklypge sigqtsdiss pelmgvgsll
     1081 kkytallcth igdilpvaas iastswrhfa evayivegdf tgvllpelvv sivlllskna
     1141 glmqeagavp llggllehld rfnhlapgke rddheelawp gimesfftgq ncrnneevtl
     1201 irkadlenhn kdggfwtvid gkvydikdfq tqsltgnsil aqfagedpvv aleaalqfed
     1261 tresmhafcv gqylepdqei vtipdlgsls splidternl glllglhasy lamstplspv
     1321 eiecakwlqs sifsgglqts qihysyneek dedhcsspgg tpasksrlcs hrralgdhsq
     1381 aflqaiadnn iqdhnvkdfl cqierycrqc hlttpimfpp ehpveevgrl llccllkhed
     1441 lghvalslvh agalgieqvk hrtlpksvvd vcrvvyqakc slikthqeqg rsykevcapv
     1501 ierlrflfne lrpavcndls imskfkllss lprwrriaqk iirerrkkrv pkkpestdde
     1561 ekigneesdl eeacilphsp invdkrpiai kspkdkwqpl lstvtgvhky kwlkqnvqgl
     1621 ypqspllsti aefalkeepv dvekmrkcll kqleraevrl egidtilkla sknfllpsvq
     1681 yamfcgwqrl ipegidigep ltdclkdvdl ippfnrmlle vtfgklyawa vqnirnvlmd
     1741 asakfkelgi qpvplqtitn enpsgpslgt ipqarfllvm lsmltlqhga nnldlllnsg
     1801 mlaltqtalr ligpscdnve edmnasaqga satvleetrk etapvqlpvs gpelaammki
     1861 gtrvmrgvdw kwgdqdgppp glgrvigelg edgwirvqwd tgstnsyrmg kegkydlkla
     1921 elpaaaqpsa edsdteddse aeqternihp tammftstin llqtlclsag vhaeimqsea
     1981 tktlcgllrm lvesgttdkt sspnrlvyre qhrswctlgf vrsialtpqv cgalsspqwi
     2041 tllmkvvegh apftatslqr qilavhllqa vlpswdkter ardmkclvek lfdflgsllt
     2101 tcssdvpllr estlrrrrvr pqasltaths stlaeevval lrtlhsltqw nglinkyins
     2161 qlrsithsfv grpsegaqle dyfpdsenpe vgglmavlav iggidgrlrl ggqvmhdefg
     2221 egtvtritpk gkitvqfsdm rtcrvcplnq lkplpavafn vnnlpftepm lsvwaqlvnl
     2281 agsklekhki kkstkqafag qvdldllrcq qlklyilkag rallshqdkl rqilsqpavq
     2341 etgtvhtddg avvspdlgdm spegpqppmi llqqllasat qpspvkaifd kqeleaaala
     2401 vcqclavest hpsspgfedc ssseattpva vqhirparvk rrkqspvpal pivvqlmemg
     2461 fsrrniefal ksltgasgna sslpgvealv gwlldhsdiq vtelsdadtv sdeysdeevv
     2521 edvddaaysm stgavvtesq tykkradfls nddyavyvre niqvgmmvrc crayeevceg
     2581 dvgkvikldr dglhdlnvqc dwqqkggtyw vryihvelig ypppsssshi kigdkvrvka
     2641 svttpkykwg svthqsvgvv kafsangkdi ivdfpqqshw tgllsemelv psihpgvtcd
     2701 gcqmfpings rfkcrncddf dfcetcfktk khntrhtfgr inepgqsavf cgrsgkqlkr
     2761 chssqpgmll dswsrmvksl nvsssvnqas rlidgsepcw qssgsqgkhw irleifpdvl
     2821 vhrlkmivdp adssympslv vvsggnslnn lielktinin psdttvplln dcteyhryie
     2881 iaikqcrssg idckihglil lgriraeeed laavpflasd neeeedekgn sgslirkkaa
     2941 glesaatirt kvfvwglndk dqlgglkgsk ikvpsfsetl salnvvqvag gskslfavtv
     3001 egkvyacgea tngrlglgis sgtvpiprqi talssyvvkk vavhsggrha taltvdgkvf
     3061 swgegddgkl ghfsrmncdk prliealktk rirdiacgss hsaaltssge lytwglgeyg
     3121 rlghgdnttq lkpkmvkvll ghrviqvacg srdaqtlalt deglvfswgd gdfgklgrgg
     3181 segcnipqni erlngqgvcq iecgaqfsla ltksgvvwtw gkgdyfrlgh gsdvhvrkpq
     3241 vveglrgkki vhvavgalhc lavtdsgqvy awgdndhgqq gngtttvnrk ptlvqglegq
     3301 kitrvacgss hsvawttvdv atpsvhepvl fqtardplga sylgvpsdad ssaasnkisg
     3361 asnskpnrps lakillsldg nlakqqalsh iltalqimya rdavvgalmp aamiapvecp
     3421 sfssaapsda samaspmnge ecmlavdied rlspnpwqek reivssedav tpsavtpsap
     3481 sasarpfipv tddlgaasii aetmtktked vesqnkaagp epqaldefts lliaddtrvv
     3541 vdllklsvcs ragdrgrdvl savlsgmgta ypqvadmlle lcvteledva tdsqsgrlss
     3601 qpvvvesshp ytddtstsgt vkipgaeglr vefdrqcste rrhdpltvmd gvnrivsvrs
     3661 grewsdwsse lripgdelkw kfisdgsvng wgwrftvypi mpaagpkell sdrcvlscps
     3721 mdlvtclldf rlnlasnrsi vprlaaslaa caqlsalaas hrmwalqrlr kllttefgqs
     3781 ininrllgen dgetralsft gsalaalvkg lpealqrqfe yedpivrggk qllhspffkv
     3841 lvalacdlel dtlpccaeth kwawfrrycm asrvavaldk rtplprlfld evakkirelm
     3901 adsenmdvlh eshdifkreq deqlvqwmnr rpddwtlsag gsgtiygwgh nhrgqlggie
     3961 gakvkvptpc ealatlrpvq liggeqtlfa vtadgklyat gygaggrlgi ggtesvstpt
     4021 llesiqhvfi kkvavnsggk hclalssege vyswgeaedg klghgnrspc drprvieslr
     4081 gievvdvaag gahsacvtaa gdlytwgkgr ygrlghsdse dqlkpklvea lqghrvvdia
     4141 cgsgdaqtlc ltdddtvwsw gdgdygklgr ggsdgckvpm kidsltglgv vkvecgsqfs
     4201 valtksgavy twgkgdyhrl ghgsddhvrr prqvqglqgk kviaiatgsl hcvcctedge
     4261 vytwgdndeg qlgdgttnai qrprlvaalq gkkvnrvacg sahtlawsts kpasagklpa
     4321 qvpmeynhlq eipiialrnr llllhhlsel fcpcipmfdl egsldetglg psvgfdtlrg
     4381 ilisqgkeaa frkvvqatmv rdrqhgpvve lnriqvkrsr skgglagpdg tksvfgqmca
     4441 kmssfgpdsl llphrvwkvk fvgesvddcg ggysesiaei ceelqngltp llivtpngrd
     4501 esganrdcyl lspaarapvh ssmfrflgvl lgiairtgsp lslnlaepvw kqlagmslti
     4561 adlsevdkdf ipglmyirdn eatseefeam slpftvpsas gqdiqlsskh thitldnrae
     4621 yvrlainyrl hefdeqvaav regmarvvpv pllslftgye letmvcgspd iplhllksva
     4681 tykgiepsas liqwfwevme sfsnterslf lrfvwgrtrl prtiadfrgr dfviqvldky
     4741 nppdhflpes ytcffllklp rysckqvlee klkyaihfck sidtddyari altgepaadd
     4801 ssddsdnedv dsfasdstqd yltgh
//
LOCUS       XP_016878184            4796 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase HERC2 isoform X3 [Homo sapiens].
ACCESSION   XP_016878184
VERSION     XP_016878184.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022695.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4796
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4796
                     /product="E3 ubiquitin-protein ligase HERC2 isoform X3"
                     /calculated_mol_wt=522802
     Region          416..737
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          1173..1244
                     /region_name="Cyt-b5"
                     /note="Cytochrome b5-like Heme/Steroid binding domain;
                     pfam00173"
                     /db_xref="CDD:459698"
     Region          1832..1892
                     /region_name="MIB_HERC2"
                     /note="Mib_herc2; pfam06701"
                     /db_xref="CDD:461991"
     Region          2422..2469
                     /region_name="UBA_HERC2"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC2 and similar proteins; cd14402"
                     /db_xref="CDD:270585"
     Region          2516..2593
                     /region_name="Cul7"
                     /note="Mouse development and cellular proliferation
                     protein Cullin-7; pfam11515"
                     /db_xref="CDD:463286"
     Region          2601..2658
                     /region_name="SH3_15"
                     /note="Mind bomb SH3 repeat domain; pfam18346"
                     /db_xref="CDD:465720"
     Region          2668..2712
                     /region_name="ZZ_HERC2"
                     /note="Zinc finger, ZZ type. Zinc finger present in HERC2
                     and related proteins. HERC2 is a potential E3 ubiquitin
                     protein ligase and/or guanine nucleotide exchange factor.
                     The ZZ motif coordinates two zinc ions and most likely
                     participates in ligand binding or...; cd02344"
                     /db_xref="CDD:239084"
     Site            order(2670,2673,2685,2688,2694,2697,2703,2707)
                     /site_type="other"
                     /note="Zinc-binding sites [ion binding]"
                     /db_xref="CDD:239084"
     Site            order(2670,2673,2694,2697)
                     /site_type="other"
                     /note="zinc cluster 1 [ion binding]"
                     /db_xref="CDD:239084"
     Site            order(2671,2682,2684,2690,2692)
                     /site_type="active"
                     /note="putative charged binding surface [active]"
                     /db_xref="CDD:239084"
     Site            order(2683,2698,2709,2712)
                     /site_type="active"
                     /note="putative hydrophobic binding surface [active]"
                     /db_xref="CDD:239084"
     Site            order(2685,2688,2703,2707)
                     /site_type="other"
                     /note="zinc cluster 2 [ion binding]"
                     /db_xref="CDD:239084"
     Region          2727..2872
                     /region_name="APC10-HERC2"
                     /note="APC10-like DOC1 domain present in HERC2 (HECT
                     domain and RLD2); cd08664"
                     /db_xref="CDD:176485"
     Site            order(2770,2798,2804,2806,2865)
                     /site_type="other"
                     /note="putative ligand binding site [chemical binding]"
                     /db_xref="CDD:176485"
     Region          2910..3263
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          3906..4254
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          4383..4754
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4389,4435,4446,4513,4684,4718..4719,4722..4726,4746,
                     4753)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4541,4544..4545,4547..4548,4551,4558,4561..4562,
                     4564,4570,4575,4592,4596)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4796
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /coded_by="XM_017022695.1:171..14561"
                     /db_xref="GeneID:8924"
                     /db_xref="HGNC:HGNC:4868"
                     /db_xref="MIM:605837"
ORIGIN      
        1 mvkdgeivyt gtestqngel pprkddsvep sgtkkedlnd kekkdeeetp apiyraksil
       61 dswvwgkqpd vnelkeclsv lvkeqqalav qsatttlsal rlkqrlvile ryfialnrtv
      121 fqenvkvkwk ssgislppvd kkssrpagkg veglarvgsr aalsfafafl rrawrsgeda
      181 dlcsellqes ldalralpea slfdestvss vwlevverat rflrsvvtgd vhgtpatkgp
      241 gsiplqdqhl alaillelav qrgtlsqmls aillllqlwd sgaqetdner saqgtsapll
      301 pllqrfqsii crkdaphseg dmhllsgpls pnesflrylt lpqdnelaid lrqtavvvma
      361 hldrlatpcm pplcssptsh kgslqevigw gligwkyyan vigpiqcegl anlgvtqiac
      421 aekrflilsr ngrvytqayn sdtlapqlvq glasrnivki aahsdghhyl alaatgevys
      481 wgcgdggrlg hgdtvpleep kvisafsgkq agkhvvhiac gstysaaita egelytwgrg
      541 nygrlghgss edeaipmlva glkglkvidv acgsgdaqtl avtengqvws wgdgdygklg
      601 rggsdgcktp klieklqdld vvkvrcgsqf sialtkdgqv yswgkgdnqr lghgteehvr
      661 ypklleglqg kkvidvaags thclalteds evhswgsndq cqhfdtlrvt kpepaalpgl
      721 dtkhivgiac gpaqsfawss csewsiglrv pfvvdicsmt feqldlllrq vsegmdgsad
      781 wpppqekecv avatlnllrl qlhaaishqv dpeflglglg sillnslkqt vvtlassagv
      841 lstvqsaaqa vlqsgwsvll ptaeeraral sallpcavsg nevnispgrr fmidllvgsl
      901 madgglesal haaitaeiqd ieakkeaqke keideqeana stfhrsrtpl dkdlintgic
      961 essgkqclpl vqliqqllrn iasqtvarlk dvarrisscl dfeqhsrers asldlllrfq
     1021 rllisklypg esigqtsdis spelmgvgsl lkkytallct higdilpvaa siastswrhf
     1081 aevayivegd ftgvllpelv vsivlllskn aglmqeagav pllggllehl drfnhlapgk
     1141 erddheelaw pgimesfftg qncrnneevt lirkadlenh nkdggfwtvi dgkvydikdf
     1201 qtqsltgnsi laqfagedpv valeaalqfe dtresmhafc vgqylepdqe ivtipdlgsl
     1261 ssplidtern lglllglhas ylamstplsp veiecakwlq ssifsgglqt sqihysynee
     1321 kdedhcsspg gtpasksrlc shrralgdhs qaflqaiadn niqdhnvkdf lcqierycrq
     1381 chlttpimfp pehpveevgr lllccllkhe dlghvalslv hagalgieqv khrtlpksvv
     1441 dvcrvvyqak cslikthqeq grsykevcap vierlrflfn elrpavcndl simskfklls
     1501 slprwrriaq kiirerrkkr vpkkpestdd eekigneesd leeacilphs pinvdkrpia
     1561 ikspkdkwqp llstvtgvhk ykwlkqnvqg lypqspllst iaefalkeep vdvekmrkcl
     1621 lkqleraevr legidtilkl asknfllpsv qyamfcgwqr lipegidige pltdclkdvd
     1681 lippfnrmll evtfgklyaw avqnirnvlm dasakfkelg iqpvplqtit nenpsgpslg
     1741 tipqarfllv mlsmltlqhg annldlllns gmlaltqtal rligpscdnv eedmnasaqg
     1801 asatvleetr ketapvqlpv sgpelaammk igtrvmrgvd wkwgdqdgpp pglgrvigel
     1861 gedgwirvqw dtgstnsyrm gkegkydlkl aelpaaaqps aedsdtedds eaeqternih
     1921 ptammftsti nllqtlclsa gvhaeimqse atktlcgllr mlvesgttdk tsspnrlvyr
     1981 eqhrswctlg fvrsialtpq vcgalsspqw itllmkvveg hapftatslq rqilavhllq
     2041 avlpswdkte rardmkclve klfdflgsll ttcssdvpll restlrrrrv rpqasltath
     2101 sstlaeevva llrtlhsltq wnglinkyin sqlrsithsf vgrpsegaql edyfpdsenp
     2161 evgglmavla viggidgrlr lggqvmhdef gegtvtritp kgkitvqfsd mrtcrvcpln
     2221 qlkplpavaf nvnnlpftep mlsvwaqlvn lagsklekhk ikkstkqafa gqvdldllrc
     2281 qqlklyilka grallshqdk lrqilsqpav qetgtvhtdd gavvspdlgd mspegpqppm
     2341 illqqllasa tqpspvkaif dkqeleaaal avcqclaves thpsspgfed cssseattpv
     2401 avqhirparv krrkqspvpa lpivvqlmem gfsrrniefa lksltgasgn asslpgveal
     2461 vgwlldhsdi qvtelsdadt vsdeysdeev vedvddaays mstgavvtes qtykkradfl
     2521 snddyavyvr eniqvgmmvr ccrayeevce gdvgkvikld rdglhdlnvq cdwqqkggty
     2581 wvryihveli gypppssssh ikigdkvrvk asvttpkykw gsvthqsvgv vkafsangkd
     2641 iivdfpqqsh wtgllsemel vpsihpgvtc dgcqmfping srfkcrncdd fdfcetcfkt
     2701 kkhntrhtfg rinepgqsav fcgrsgkqlk rchssqpgml ldswsrmvks lnvsssvnqa
     2761 srlidgsepc wqssgsqgkh wirleifpdv lvhrlkmivd padssympsl vvvsggnsln
     2821 nlielktini npsdttvpll ndcteyhryi eiaikqcrss gidckihgli llgriraeee
     2881 dlaavpflas dneeeedekg nsgslirkka aglesaatir tkvfvwglnd kdqlgglkgs
     2941 kikvpsfset lsalnvvqva ggskslfavt vegkvyacge atngrlglgi ssgtvpiprq
     3001 italssyvvk kvavhsggrh ataltvdgkv fswgegddgk lghfsrmncd kprliealkt
     3061 krirdiacgs shsaaltssg elytwglgey grlghgdntt qlkpkmvkvl lghrviqvac
     3121 gsrdaqtlal tdeglvfswg dgdfgklgrg gsegcnipqn ierlngqgvc qiecgaqfsl
     3181 altksgvvwt wgkgdyfrlg hgsdvhvrkp qvveglrgkk ivhvavgalh clavtdsgqv
     3241 yawgdndhgq qgngtttvnr kptlvqgleg qkitrvacgs shsvawttvd vatpsvhepv
     3301 lfqtardplg asylgvpsda dssaasnkis gasnskpnrp slakillsld gnlakqqals
     3361 hiltalqimy ardavvgalm paamiapvec psfssaapsd asamaspmng eecmlavdie
     3421 drlspnpwqe kreivsseda vtpsavtpsa psasarpfip vtddlgaasi iaetmtktke
     3481 dvesqnkaag pepqaldeft slliaddtrv vvdllklsvc sragdrgrdv lsavlsgmgt
     3541 aypqvadmll elcvteledv atdsqsgrls sqpvvvessh pytddtstsg tvkipgaegl
     3601 rvefdrqcst errhdpltvm dgvnrivsvr sgrewsdwss elripgdelk wkfisdgsvn
     3661 gwgwrftvyp impaagpkel lsdrcvlscp smdlvtclld frlnlasnrs ivprlaasla
     3721 acaqlsalaa shrmwalqrl rkllttefgq sininrllge ndgetralsf tgsalaalvk
     3781 glpealqrqf eyedpivrgg kqllhspffk vlvalacdle ldtlpccaet hkwawfrryc
     3841 masrvavald krtplprlfl devakkirel madsenmdvl heshdifkre qdeqlvqwmn
     3901 rrpddwtlsa ggsgtiygwg hnhrgqlggi egakvkvptp cealatlrpv qliggeqtlf
     3961 avtadgklya tgygaggrlg iggtesvstp tllesiqhvf ikkvavnsgg khclalsseg
     4021 evyswgeaed gklghgnrsp cdrprviesl rgievvdvaa ggahsacvta agdlytwgkg
     4081 rygrlghsds edqlkpklve alqghrvvdi acgsgdaqtl cltdddtvws wgdgdygklg
     4141 rggsdgckvp mkidsltglg vvkvecgsqf svaltksgav ytwgkgdyhr lghgsddhvr
     4201 rprqvqglqg kkviaiatgs lhcvcctedg evytwgdnde gqlgdgttna iqrprlvaal
     4261 qgkkvnrvac gsahtlawst skpasagklp aqvpmeynhl qeipiialrn rllllhhlse
     4321 lfcpcipmfd legsldetgl gpsvgfdtlr gilisqgkea afrkvvqatm vrdrqhgpvv
     4381 elnriqvkrs rskgglagpd gtksvfgqmc akmssfgpds lllphrvwkv kfvgesvddc
     4441 gggysesiae iceelqnglt pllivtpngr desganrdcy llspaarapv hssmfrflgv
     4501 llgiairtgs plslnlaepv wkqlagmslt iadlsevdkd fipglmyird neatseefea
     4561 mslpftvpsa sgqdiqlssk hthitldnra eyvrlainyr lhefdeqvaa vregmarvvp
     4621 vpllslftgy eletmvcgsp diplhllksv atykgiepsa sliqwfwevm esfsntersl
     4681 flrfvwgrtr lprtiadfrg rdfviqvldk ynppdhflpe sytcffllkl prysckqvle
     4741 eklkyaihfc ksidtddyar ialtgepaad dssddsdned vdsfasdstq dyltgh
//
LOCUS       XP_016878185            4796 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase HERC2 isoform X3 [Homo sapiens].
ACCESSION   XP_016878185
VERSION     XP_016878185.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022696.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4796
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4796
                     /product="E3 ubiquitin-protein ligase HERC2 isoform X3"
                     /calculated_mol_wt=522802
     Region          416..737
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          1173..1244
                     /region_name="Cyt-b5"
                     /note="Cytochrome b5-like Heme/Steroid binding domain;
                     pfam00173"
                     /db_xref="CDD:459698"
     Region          1832..1892
                     /region_name="MIB_HERC2"
                     /note="Mib_herc2; pfam06701"
                     /db_xref="CDD:461991"
     Region          2422..2469
                     /region_name="UBA_HERC2"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC2 and similar proteins; cd14402"
                     /db_xref="CDD:270585"
     Region          2516..2593
                     /region_name="Cul7"
                     /note="Mouse development and cellular proliferation
                     protein Cullin-7; pfam11515"
                     /db_xref="CDD:463286"
     Region          2601..2658
                     /region_name="SH3_15"
                     /note="Mind bomb SH3 repeat domain; pfam18346"
                     /db_xref="CDD:465720"
     Region          2668..2712
                     /region_name="ZZ_HERC2"
                     /note="Zinc finger, ZZ type. Zinc finger present in HERC2
                     and related proteins. HERC2 is a potential E3 ubiquitin
                     protein ligase and/or guanine nucleotide exchange factor.
                     The ZZ motif coordinates two zinc ions and most likely
                     participates in ligand binding or...; cd02344"
                     /db_xref="CDD:239084"
     Site            order(2670,2673,2685,2688,2694,2697,2703,2707)
                     /site_type="other"
                     /note="Zinc-binding sites [ion binding]"
                     /db_xref="CDD:239084"
     Site            order(2670,2673,2694,2697)
                     /site_type="other"
                     /note="zinc cluster 1 [ion binding]"
                     /db_xref="CDD:239084"
     Site            order(2671,2682,2684,2690,2692)
                     /site_type="active"
                     /note="putative charged binding surface [active]"
                     /db_xref="CDD:239084"
     Site            order(2683,2698,2709,2712)
                     /site_type="active"
                     /note="putative hydrophobic binding surface [active]"
                     /db_xref="CDD:239084"
     Site            order(2685,2688,2703,2707)
                     /site_type="other"
                     /note="zinc cluster 2 [ion binding]"
                     /db_xref="CDD:239084"
     Region          2727..2872
                     /region_name="APC10-HERC2"
                     /note="APC10-like DOC1 domain present in HERC2 (HECT
                     domain and RLD2); cd08664"
                     /db_xref="CDD:176485"
     Site            order(2770,2798,2804,2806,2865)
                     /site_type="other"
                     /note="putative ligand binding site [chemical binding]"
                     /db_xref="CDD:176485"
     Region          2910..3263
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          3906..4254
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          4383..4754
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4389,4435,4446,4513,4684,4718..4719,4722..4726,4746,
                     4753)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4541,4544..4545,4547..4548,4551,4558,4561..4562,
                     4564,4570,4575,4592,4596)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4796
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /coded_by="XM_017022696.2:68..14458"
                     /db_xref="GeneID:8924"
                     /db_xref="HGNC:HGNC:4868"
                     /db_xref="MIM:605837"
ORIGIN      
        1 mvkdgeivyt gtestqngel pprkddsvep sgtkkedlnd kekkdeeetp apiyraksil
       61 dswvwgkqpd vnelkeclsv lvkeqqalav qsatttlsal rlkqrlvile ryfialnrtv
      121 fqenvkvkwk ssgislppvd kkssrpagkg veglarvgsr aalsfafafl rrawrsgeda
      181 dlcsellqes ldalralpea slfdestvss vwlevverat rflrsvvtgd vhgtpatkgp
      241 gsiplqdqhl alaillelav qrgtlsqmls aillllqlwd sgaqetdner saqgtsapll
      301 pllqrfqsii crkdaphseg dmhllsgpls pnesflrylt lpqdnelaid lrqtavvvma
      361 hldrlatpcm pplcssptsh kgslqevigw gligwkyyan vigpiqcegl anlgvtqiac
      421 aekrflilsr ngrvytqayn sdtlapqlvq glasrnivki aahsdghhyl alaatgevys
      481 wgcgdggrlg hgdtvpleep kvisafsgkq agkhvvhiac gstysaaita egelytwgrg
      541 nygrlghgss edeaipmlva glkglkvidv acgsgdaqtl avtengqvws wgdgdygklg
      601 rggsdgcktp klieklqdld vvkvrcgsqf sialtkdgqv yswgkgdnqr lghgteehvr
      661 ypklleglqg kkvidvaags thclalteds evhswgsndq cqhfdtlrvt kpepaalpgl
      721 dtkhivgiac gpaqsfawss csewsiglrv pfvvdicsmt feqldlllrq vsegmdgsad
      781 wpppqekecv avatlnllrl qlhaaishqv dpeflglglg sillnslkqt vvtlassagv
      841 lstvqsaaqa vlqsgwsvll ptaeeraral sallpcavsg nevnispgrr fmidllvgsl
      901 madgglesal haaitaeiqd ieakkeaqke keideqeana stfhrsrtpl dkdlintgic
      961 essgkqclpl vqliqqllrn iasqtvarlk dvarrisscl dfeqhsrers asldlllrfq
     1021 rllisklypg esigqtsdis spelmgvgsl lkkytallct higdilpvaa siastswrhf
     1081 aevayivegd ftgvllpelv vsivlllskn aglmqeagav pllggllehl drfnhlapgk
     1141 erddheelaw pgimesfftg qncrnneevt lirkadlenh nkdggfwtvi dgkvydikdf
     1201 qtqsltgnsi laqfagedpv valeaalqfe dtresmhafc vgqylepdqe ivtipdlgsl
     1261 ssplidtern lglllglhas ylamstplsp veiecakwlq ssifsgglqt sqihysynee
     1321 kdedhcsspg gtpasksrlc shrralgdhs qaflqaiadn niqdhnvkdf lcqierycrq
     1381 chlttpimfp pehpveevgr lllccllkhe dlghvalslv hagalgieqv khrtlpksvv
     1441 dvcrvvyqak cslikthqeq grsykevcap vierlrflfn elrpavcndl simskfklls
     1501 slprwrriaq kiirerrkkr vpkkpestdd eekigneesd leeacilphs pinvdkrpia
     1561 ikspkdkwqp llstvtgvhk ykwlkqnvqg lypqspllst iaefalkeep vdvekmrkcl
     1621 lkqleraevr legidtilkl asknfllpsv qyamfcgwqr lipegidige pltdclkdvd
     1681 lippfnrmll evtfgklyaw avqnirnvlm dasakfkelg iqpvplqtit nenpsgpslg
     1741 tipqarfllv mlsmltlqhg annldlllns gmlaltqtal rligpscdnv eedmnasaqg
     1801 asatvleetr ketapvqlpv sgpelaammk igtrvmrgvd wkwgdqdgpp pglgrvigel
     1861 gedgwirvqw dtgstnsyrm gkegkydlkl aelpaaaqps aedsdtedds eaeqternih
     1921 ptammftsti nllqtlclsa gvhaeimqse atktlcgllr mlvesgttdk tsspnrlvyr
     1981 eqhrswctlg fvrsialtpq vcgalsspqw itllmkvveg hapftatslq rqilavhllq
     2041 avlpswdkte rardmkclve klfdflgsll ttcssdvpll restlrrrrv rpqasltath
     2101 sstlaeevva llrtlhsltq wnglinkyin sqlrsithsf vgrpsegaql edyfpdsenp
     2161 evgglmavla viggidgrlr lggqvmhdef gegtvtritp kgkitvqfsd mrtcrvcpln
     2221 qlkplpavaf nvnnlpftep mlsvwaqlvn lagsklekhk ikkstkqafa gqvdldllrc
     2281 qqlklyilka grallshqdk lrqilsqpav qetgtvhtdd gavvspdlgd mspegpqppm
     2341 illqqllasa tqpspvkaif dkqeleaaal avcqclaves thpsspgfed cssseattpv
     2401 avqhirparv krrkqspvpa lpivvqlmem gfsrrniefa lksltgasgn asslpgveal
     2461 vgwlldhsdi qvtelsdadt vsdeysdeev vedvddaays mstgavvtes qtykkradfl
     2521 snddyavyvr eniqvgmmvr ccrayeevce gdvgkvikld rdglhdlnvq cdwqqkggty
     2581 wvryihveli gypppssssh ikigdkvrvk asvttpkykw gsvthqsvgv vkafsangkd
     2641 iivdfpqqsh wtgllsemel vpsihpgvtc dgcqmfping srfkcrncdd fdfcetcfkt
     2701 kkhntrhtfg rinepgqsav fcgrsgkqlk rchssqpgml ldswsrmvks lnvsssvnqa
     2761 srlidgsepc wqssgsqgkh wirleifpdv lvhrlkmivd padssympsl vvvsggnsln
     2821 nlielktini npsdttvpll ndcteyhryi eiaikqcrss gidckihgli llgriraeee
     2881 dlaavpflas dneeeedekg nsgslirkka aglesaatir tkvfvwglnd kdqlgglkgs
     2941 kikvpsfset lsalnvvqva ggskslfavt vegkvyacge atngrlglgi ssgtvpiprq
     3001 italssyvvk kvavhsggrh ataltvdgkv fswgegddgk lghfsrmncd kprliealkt
     3061 krirdiacgs shsaaltssg elytwglgey grlghgdntt qlkpkmvkvl lghrviqvac
     3121 gsrdaqtlal tdeglvfswg dgdfgklgrg gsegcnipqn ierlngqgvc qiecgaqfsl
     3181 altksgvvwt wgkgdyfrlg hgsdvhvrkp qvveglrgkk ivhvavgalh clavtdsgqv
     3241 yawgdndhgq qgngtttvnr kptlvqgleg qkitrvacgs shsvawttvd vatpsvhepv
     3301 lfqtardplg asylgvpsda dssaasnkis gasnskpnrp slakillsld gnlakqqals
     3361 hiltalqimy ardavvgalm paamiapvec psfssaapsd asamaspmng eecmlavdie
     3421 drlspnpwqe kreivsseda vtpsavtpsa psasarpfip vtddlgaasi iaetmtktke
     3481 dvesqnkaag pepqaldeft slliaddtrv vvdllklsvc sragdrgrdv lsavlsgmgt
     3541 aypqvadmll elcvteledv atdsqsgrls sqpvvvessh pytddtstsg tvkipgaegl
     3601 rvefdrqcst errhdpltvm dgvnrivsvr sgrewsdwss elripgdelk wkfisdgsvn
     3661 gwgwrftvyp impaagpkel lsdrcvlscp smdlvtclld frlnlasnrs ivprlaasla
     3721 acaqlsalaa shrmwalqrl rkllttefgq sininrllge ndgetralsf tgsalaalvk
     3781 glpealqrqf eyedpivrgg kqllhspffk vlvalacdle ldtlpccaet hkwawfrryc
     3841 masrvavald krtplprlfl devakkirel madsenmdvl heshdifkre qdeqlvqwmn
     3901 rrpddwtlsa ggsgtiygwg hnhrgqlggi egakvkvptp cealatlrpv qliggeqtlf
     3961 avtadgklya tgygaggrlg iggtesvstp tllesiqhvf ikkvavnsgg khclalsseg
     4021 evyswgeaed gklghgnrsp cdrprviesl rgievvdvaa ggahsacvta agdlytwgkg
     4081 rygrlghsds edqlkpklve alqghrvvdi acgsgdaqtl cltdddtvws wgdgdygklg
     4141 rggsdgckvp mkidsltglg vvkvecgsqf svaltksgav ytwgkgdyhr lghgsddhvr
     4201 rprqvqglqg kkviaiatgs lhcvcctedg evytwgdnde gqlgdgttna iqrprlvaal
     4261 qgkkvnrvac gsahtlawst skpasagklp aqvpmeynhl qeipiialrn rllllhhlse
     4321 lfcpcipmfd legsldetgl gpsvgfdtlr gilisqgkea afrkvvqatm vrdrqhgpvv
     4381 elnriqvkrs rskgglagpd gtksvfgqmc akmssfgpds lllphrvwkv kfvgesvddc
     4441 gggysesiae iceelqnglt pllivtpngr desganrdcy llspaarapv hssmfrflgv
     4501 llgiairtgs plslnlaepv wkqlagmslt iadlsevdkd fipglmyird neatseefea
     4561 mslpftvpsa sgqdiqlssk hthitldnra eyvrlainyr lhefdeqvaa vregmarvvp
     4621 vpllslftgy eletmvcgsp diplhllksv atykgiepsa sliqwfwevm esfsntersl
     4681 flrfvwgrtr lprtiadfrg rdfviqvldk ynppdhflpe sytcffllkl prysckqvle
     4741 eklkyaihfc ksidtddyar ialtgepaad dssddsdned vdsfasdstq dyltgh
//
LOCUS       XP_005268333            4796 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase HERC2 isoform X3 [Homo sapiens].
ACCESSION   XP_005268333
VERSION     XP_005268333.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005268276.6
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4796
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4796
                     /product="E3 ubiquitin-protein ligase HERC2 isoform X3"
                     /calculated_mol_wt=522802
     Region          416..737
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          1173..1244
                     /region_name="Cyt-b5"
                     /note="Cytochrome b5-like Heme/Steroid binding domain;
                     pfam00173"
                     /db_xref="CDD:459698"
     Region          1832..1892
                     /region_name="MIB_HERC2"
                     /note="Mib_herc2; pfam06701"
                     /db_xref="CDD:461991"
     Region          2422..2469
                     /region_name="UBA_HERC2"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC2 and similar proteins; cd14402"
                     /db_xref="CDD:270585"
     Region          2516..2593
                     /region_name="Cul7"
                     /note="Mouse development and cellular proliferation
                     protein Cullin-7; pfam11515"
                     /db_xref="CDD:463286"
     Region          2601..2658
                     /region_name="SH3_15"
                     /note="Mind bomb SH3 repeat domain; pfam18346"
                     /db_xref="CDD:465720"
     Region          2668..2712
                     /region_name="ZZ_HERC2"
                     /note="Zinc finger, ZZ type. Zinc finger present in HERC2
                     and related proteins. HERC2 is a potential E3 ubiquitin
                     protein ligase and/or guanine nucleotide exchange factor.
                     The ZZ motif coordinates two zinc ions and most likely
                     participates in ligand binding or...; cd02344"
                     /db_xref="CDD:239084"
     Site            order(2670,2673,2685,2688,2694,2697,2703,2707)
                     /site_type="other"
                     /note="Zinc-binding sites [ion binding]"
                     /db_xref="CDD:239084"
     Site            order(2670,2673,2694,2697)
                     /site_type="other"
                     /note="zinc cluster 1 [ion binding]"
                     /db_xref="CDD:239084"
     Site            order(2671,2682,2684,2690,2692)
                     /site_type="active"
                     /note="putative charged binding surface [active]"
                     /db_xref="CDD:239084"
     Site            order(2683,2698,2709,2712)
                     /site_type="active"
                     /note="putative hydrophobic binding surface [active]"
                     /db_xref="CDD:239084"
     Site            order(2685,2688,2703,2707)
                     /site_type="other"
                     /note="zinc cluster 2 [ion binding]"
                     /db_xref="CDD:239084"
     Region          2727..2872
                     /region_name="APC10-HERC2"
                     /note="APC10-like DOC1 domain present in HERC2 (HECT
                     domain and RLD2); cd08664"
                     /db_xref="CDD:176485"
     Site            order(2770,2798,2804,2806,2865)
                     /site_type="other"
                     /note="putative ligand binding site [chemical binding]"
                     /db_xref="CDD:176485"
     Region          2910..3263
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          3906..4254
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          4383..4754
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4389,4435,4446,4513,4684,4718..4719,4722..4726,4746,
                     4753)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4541,4544..4545,4547..4548,4551,4558,4561..4562,
                     4564,4570,4575,4592,4596)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4796
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /coded_by="XM_005268276.6:363..14753"
                     /db_xref="GeneID:8924"
                     /db_xref="HGNC:HGNC:4868"
                     /db_xref="MIM:605837"
ORIGIN      
        1 mvkdgeivyt gtestqngel pprkddsvep sgtkkedlnd kekkdeeetp apiyraksil
       61 dswvwgkqpd vnelkeclsv lvkeqqalav qsatttlsal rlkqrlvile ryfialnrtv
      121 fqenvkvkwk ssgislppvd kkssrpagkg veglarvgsr aalsfafafl rrawrsgeda
      181 dlcsellqes ldalralpea slfdestvss vwlevverat rflrsvvtgd vhgtpatkgp
      241 gsiplqdqhl alaillelav qrgtlsqmls aillllqlwd sgaqetdner saqgtsapll
      301 pllqrfqsii crkdaphseg dmhllsgpls pnesflrylt lpqdnelaid lrqtavvvma
      361 hldrlatpcm pplcssptsh kgslqevigw gligwkyyan vigpiqcegl anlgvtqiac
      421 aekrflilsr ngrvytqayn sdtlapqlvq glasrnivki aahsdghhyl alaatgevys
      481 wgcgdggrlg hgdtvpleep kvisafsgkq agkhvvhiac gstysaaita egelytwgrg
      541 nygrlghgss edeaipmlva glkglkvidv acgsgdaqtl avtengqvws wgdgdygklg
      601 rggsdgcktp klieklqdld vvkvrcgsqf sialtkdgqv yswgkgdnqr lghgteehvr
      661 ypklleglqg kkvidvaags thclalteds evhswgsndq cqhfdtlrvt kpepaalpgl
      721 dtkhivgiac gpaqsfawss csewsiglrv pfvvdicsmt feqldlllrq vsegmdgsad
      781 wpppqekecv avatlnllrl qlhaaishqv dpeflglglg sillnslkqt vvtlassagv
      841 lstvqsaaqa vlqsgwsvll ptaeeraral sallpcavsg nevnispgrr fmidllvgsl
      901 madgglesal haaitaeiqd ieakkeaqke keideqeana stfhrsrtpl dkdlintgic
      961 essgkqclpl vqliqqllrn iasqtvarlk dvarrisscl dfeqhsrers asldlllrfq
     1021 rllisklypg esigqtsdis spelmgvgsl lkkytallct higdilpvaa siastswrhf
     1081 aevayivegd ftgvllpelv vsivlllskn aglmqeagav pllggllehl drfnhlapgk
     1141 erddheelaw pgimesfftg qncrnneevt lirkadlenh nkdggfwtvi dgkvydikdf
     1201 qtqsltgnsi laqfagedpv valeaalqfe dtresmhafc vgqylepdqe ivtipdlgsl
     1261 ssplidtern lglllglhas ylamstplsp veiecakwlq ssifsgglqt sqihysynee
     1321 kdedhcsspg gtpasksrlc shrralgdhs qaflqaiadn niqdhnvkdf lcqierycrq
     1381 chlttpimfp pehpveevgr lllccllkhe dlghvalslv hagalgieqv khrtlpksvv
     1441 dvcrvvyqak cslikthqeq grsykevcap vierlrflfn elrpavcndl simskfklls
     1501 slprwrriaq kiirerrkkr vpkkpestdd eekigneesd leeacilphs pinvdkrpia
     1561 ikspkdkwqp llstvtgvhk ykwlkqnvqg lypqspllst iaefalkeep vdvekmrkcl
     1621 lkqleraevr legidtilkl asknfllpsv qyamfcgwqr lipegidige pltdclkdvd
     1681 lippfnrmll evtfgklyaw avqnirnvlm dasakfkelg iqpvplqtit nenpsgpslg
     1741 tipqarfllv mlsmltlqhg annldlllns gmlaltqtal rligpscdnv eedmnasaqg
     1801 asatvleetr ketapvqlpv sgpelaammk igtrvmrgvd wkwgdqdgpp pglgrvigel
     1861 gedgwirvqw dtgstnsyrm gkegkydlkl aelpaaaqps aedsdtedds eaeqternih
     1921 ptammftsti nllqtlclsa gvhaeimqse atktlcgllr mlvesgttdk tsspnrlvyr
     1981 eqhrswctlg fvrsialtpq vcgalsspqw itllmkvveg hapftatslq rqilavhllq
     2041 avlpswdkte rardmkclve klfdflgsll ttcssdvpll restlrrrrv rpqasltath
     2101 sstlaeevva llrtlhsltq wnglinkyin sqlrsithsf vgrpsegaql edyfpdsenp
     2161 evgglmavla viggidgrlr lggqvmhdef gegtvtritp kgkitvqfsd mrtcrvcpln
     2221 qlkplpavaf nvnnlpftep mlsvwaqlvn lagsklekhk ikkstkqafa gqvdldllrc
     2281 qqlklyilka grallshqdk lrqilsqpav qetgtvhtdd gavvspdlgd mspegpqppm
     2341 illqqllasa tqpspvkaif dkqeleaaal avcqclaves thpsspgfed cssseattpv
     2401 avqhirparv krrkqspvpa lpivvqlmem gfsrrniefa lksltgasgn asslpgveal
     2461 vgwlldhsdi qvtelsdadt vsdeysdeev vedvddaays mstgavvtes qtykkradfl
     2521 snddyavyvr eniqvgmmvr ccrayeevce gdvgkvikld rdglhdlnvq cdwqqkggty
     2581 wvryihveli gypppssssh ikigdkvrvk asvttpkykw gsvthqsvgv vkafsangkd
     2641 iivdfpqqsh wtgllsemel vpsihpgvtc dgcqmfping srfkcrncdd fdfcetcfkt
     2701 kkhntrhtfg rinepgqsav fcgrsgkqlk rchssqpgml ldswsrmvks lnvsssvnqa
     2761 srlidgsepc wqssgsqgkh wirleifpdv lvhrlkmivd padssympsl vvvsggnsln
     2821 nlielktini npsdttvpll ndcteyhryi eiaikqcrss gidckihgli llgriraeee
     2881 dlaavpflas dneeeedekg nsgslirkka aglesaatir tkvfvwglnd kdqlgglkgs
     2941 kikvpsfset lsalnvvqva ggskslfavt vegkvyacge atngrlglgi ssgtvpiprq
     3001 italssyvvk kvavhsggrh ataltvdgkv fswgegddgk lghfsrmncd kprliealkt
     3061 krirdiacgs shsaaltssg elytwglgey grlghgdntt qlkpkmvkvl lghrviqvac
     3121 gsrdaqtlal tdeglvfswg dgdfgklgrg gsegcnipqn ierlngqgvc qiecgaqfsl
     3181 altksgvvwt wgkgdyfrlg hgsdvhvrkp qvveglrgkk ivhvavgalh clavtdsgqv
     3241 yawgdndhgq qgngtttvnr kptlvqgleg qkitrvacgs shsvawttvd vatpsvhepv
     3301 lfqtardplg asylgvpsda dssaasnkis gasnskpnrp slakillsld gnlakqqals
     3361 hiltalqimy ardavvgalm paamiapvec psfssaapsd asamaspmng eecmlavdie
     3421 drlspnpwqe kreivsseda vtpsavtpsa psasarpfip vtddlgaasi iaetmtktke
     3481 dvesqnkaag pepqaldeft slliaddtrv vvdllklsvc sragdrgrdv lsavlsgmgt
     3541 aypqvadmll elcvteledv atdsqsgrls sqpvvvessh pytddtstsg tvkipgaegl
     3601 rvefdrqcst errhdpltvm dgvnrivsvr sgrewsdwss elripgdelk wkfisdgsvn
     3661 gwgwrftvyp impaagpkel lsdrcvlscp smdlvtclld frlnlasnrs ivprlaasla
     3721 acaqlsalaa shrmwalqrl rkllttefgq sininrllge ndgetralsf tgsalaalvk
     3781 glpealqrqf eyedpivrgg kqllhspffk vlvalacdle ldtlpccaet hkwawfrryc
     3841 masrvavald krtplprlfl devakkirel madsenmdvl heshdifkre qdeqlvqwmn
     3901 rrpddwtlsa ggsgtiygwg hnhrgqlggi egakvkvptp cealatlrpv qliggeqtlf
     3961 avtadgklya tgygaggrlg iggtesvstp tllesiqhvf ikkvavnsgg khclalsseg
     4021 evyswgeaed gklghgnrsp cdrprviesl rgievvdvaa ggahsacvta agdlytwgkg
     4081 rygrlghsds edqlkpklve alqghrvvdi acgsgdaqtl cltdddtvws wgdgdygklg
     4141 rggsdgckvp mkidsltglg vvkvecgsqf svaltksgav ytwgkgdyhr lghgsddhvr
     4201 rprqvqglqg kkviaiatgs lhcvcctedg evytwgdnde gqlgdgttna iqrprlvaal
     4261 qgkkvnrvac gsahtlawst skpasagklp aqvpmeynhl qeipiialrn rllllhhlse
     4321 lfcpcipmfd legsldetgl gpsvgfdtlr gilisqgkea afrkvvqatm vrdrqhgpvv
     4381 elnriqvkrs rskgglagpd gtksvfgqmc akmssfgpds lllphrvwkv kfvgesvddc
     4441 gggysesiae iceelqnglt pllivtpngr desganrdcy llspaarapv hssmfrflgv
     4501 llgiairtgs plslnlaepv wkqlagmslt iadlsevdkd fipglmyird neatseefea
     4561 mslpftvpsa sgqdiqlssk hthitldnra eyvrlainyr lhefdeqvaa vregmarvvp
     4621 vpllslftgy eletmvcgsp diplhllksv atykgiepsa sliqwfwevm esfsntersl
     4681 flrfvwgrtr lprtiadfrg rdfviqvldk ynppdhflpe sytcffllkl prysckqvle
     4741 eklkyaihfc ksidtddyar ialtgepaad dssddsdned vdsfasdstq dyltgh
//
LOCUS       XP_006720790            4748 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase HERC2 isoform X4 [Homo sapiens].
ACCESSION   XP_006720790
VERSION     XP_006720790.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720727.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4748
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4748
                     /product="E3 ubiquitin-protein ligase HERC2 isoform X4"
                     /calculated_mol_wt=517844
     Region          368..689
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          1125..1196
                     /region_name="Cyt-b5"
                     /note="Cytochrome b5-like Heme/Steroid binding domain;
                     pfam00173"
                     /db_xref="CDD:459698"
     Region          1784..1844
                     /region_name="MIB_HERC2"
                     /note="Mib_herc2; pfam06701"
                     /db_xref="CDD:461991"
     Region          2374..2421
                     /region_name="UBA_HERC2"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC2 and similar proteins; cd14402"
                     /db_xref="CDD:270585"
     Region          2468..2545
                     /region_name="Cul7"
                     /note="Mouse development and cellular proliferation
                     protein Cullin-7; pfam11515"
                     /db_xref="CDD:463286"
     Region          2553..2610
                     /region_name="SH3_15"
                     /note="Mind bomb SH3 repeat domain; pfam18346"
                     /db_xref="CDD:465720"
     Region          2620..2664
                     /region_name="ZZ_HERC2"
                     /note="Zinc finger, ZZ type. Zinc finger present in HERC2
                     and related proteins. HERC2 is a potential E3 ubiquitin
                     protein ligase and/or guanine nucleotide exchange factor.
                     The ZZ motif coordinates two zinc ions and most likely
                     participates in ligand binding or...; cd02344"
                     /db_xref="CDD:239084"
     Site            order(2622,2625,2637,2640,2646,2649,2655,2659)
                     /site_type="other"
                     /note="Zinc-binding sites [ion binding]"
                     /db_xref="CDD:239084"
     Site            order(2622,2625,2646,2649)
                     /site_type="other"
                     /note="zinc cluster 1 [ion binding]"
                     /db_xref="CDD:239084"
     Site            order(2623,2634,2636,2642,2644)
                     /site_type="active"
                     /note="putative charged binding surface [active]"
                     /db_xref="CDD:239084"
     Site            order(2635,2650,2661,2664)
                     /site_type="active"
                     /note="putative hydrophobic binding surface [active]"
                     /db_xref="CDD:239084"
     Site            order(2637,2640,2655,2659)
                     /site_type="other"
                     /note="zinc cluster 2 [ion binding]"
                     /db_xref="CDD:239084"
     Region          2679..2824
                     /region_name="APC10-HERC2"
                     /note="APC10-like DOC1 domain present in HERC2 (HECT
                     domain and RLD2); cd08664"
                     /db_xref="CDD:176485"
     Site            order(2722,2750,2756,2758,2817)
                     /site_type="other"
                     /note="putative ligand binding site [chemical binding]"
                     /db_xref="CDD:176485"
     Region          2862..3215
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          3858..4206
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          4335..4706
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4341,4387,4398,4465,4636,4670..4671,4674..4678,4698,
                     4705)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4493,4496..4497,4499..4500,4503,4510,4513..4514,
                     4516,4522,4527,4544,4548)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4748
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /coded_by="XM_006720727.4:137..14383"
                     /db_xref="GeneID:8924"
                     /db_xref="HGNC:HGNC:4868"
                     /db_xref="MIM:605837"
ORIGIN      
        1 mpsesfclaa qarldskwlk tdiqlaftrd glcglwnemv kdgeivytgt estqngelpp
       61 rkddsvepsg tkkedlndke kkdeeetpap iyraksilds wvwgkqpdvn elkeclsvlv
      121 keqqalavqs atttlsalrl kqrlvilery fialnrtvfq envkvkwkss gislppvdkk
      181 rdvhgtpatk gpgsiplqdq hlalaillel avqrgtlsqm lsaillllql wdsgaqetdn
      241 ersaqgtsap llpllqrfqs iicrkdaphs egdmhllsgp lspnesflry ltlpqdnela
      301 idlrqtavvv mahldrlatp cmpplcsspt shkgslqevi gwgligwkyy anvigpiqce
      361 glanlgvtqi acaekrflil srngrvytqa ynsdtlapql vqglasrniv kiaahsdghh
      421 ylalaatgev yswgcgdggr lghgdtvple epkvisafsg kqagkhvvhi acgstysaai
      481 taegelytwg rgnygrlghg ssedeaipml vaglkglkvi dvacgsgdaq tlavtengqv
      541 wswgdgdygk lgrggsdgck tpklieklqd ldvvkvrcgs qfsialtkdg qvyswgkgdn
      601 qrlghgteeh vrypkllegl qgkkvidvaa gsthclalte dsevhswgsn dqcqhfdtlr
      661 vtkpepaalp gldtkhivgi acgpaqsfaw sscsewsigl rvpfvvdics mtfeqldlll
      721 rqvsegmdgs adwpppqeke cvavatlnll rlqlhaaish qvdpeflglg lgsillnslk
      781 qtvvtlassa gvlstvqsaa qavlqsgwsv llptaeerar alsallpcav sgnevnispg
      841 rrfmidllvg slmadggles alhaaitaei qdieakkeaq kekeideqea nastfhrsrt
      901 pldkdlintg icessgkqcl plvqliqqll rniasqtvar lkdvarriss cldfeqhsre
      961 rsasldlllr fqrlliskly pgesigqtsd isspelmgvg sllkkytall cthigdilpv
     1021 aasiastswr hfaevayive gdftgvllpe lvvsivllls knaglmqeag avpllgglle
     1081 hldrfnhlap gkerddheel awpgimesff tgqncrnnee vtlirkadle nhnkdggfwt
     1141 vidgkvydik dfqtqsltgn silaqfaged pvvaleaalq fedtresmha fcvgqylepd
     1201 qeivtipdlg slssplidte rnlglllglh asylamstpl spveiecakw lqssifsggl
     1261 qtsqihysyn eekdedhcss pggtpasksr lcshrralgd hsqaflqaia dnniqdhnvk
     1321 dflcqieryc rqchlttpim fppehpveev grlllccllk hedlghvals lvhagalgie
     1381 qvkhrtlpks vvdvcrvvyq akcslikthq eqgrsykevc apvierlrfl fnelrpavcn
     1441 dlsimskfkl lsslprwrri aqkiirerrk krvpkkpest ddeekignee sdleeacilp
     1501 hspinvdkrp iaikspkdkw qpllstvtgv hkykwlkqnv qglypqspll stiaefalke
     1561 epvdvekmrk cllkqlerae vrlegidtil klasknfllp svqyamfcgw qrlipegidi
     1621 gepltdclkd vdlippfnrm llevtfgkly awavqnirnv lmdasakfke lgiqpvplqt
     1681 itnenpsgps lgtipqarfl lvmlsmltlq hgannldlll nsgmlaltqt alrligpscd
     1741 nveedmnasa qgasatvlee trketapvql pvsgpelaam mkigtrvmrg vdwkwgdqdg
     1801 pppglgrvig elgedgwirv qwdtgstnsy rmgkegkydl klaelpaaaq psaedsdted
     1861 dseaeqtern ihptammfts tinllqtlcl sagvhaeimq seatktlcgl lrmlvesgtt
     1921 dktsspnrlv yreqhrswct lgfvrsialt pqvcgalssp qwitllmkvv eghapftats
     1981 lqrqilavhl lqavlpswdk terardmkcl veklfdflgs llttcssdvp llrestlrrr
     2041 rvrpqaslta thsstlaeev vallrtlhsl tqwnglinky insqlrsith sfvgrpsega
     2101 qledyfpdse npevgglmav laviggidgr lrlggqvmhd efgegtvtri tpkgkitvqf
     2161 sdmrtcrvcp lnqlkplpav afnvnnlpft epmlsvwaql vnlagsklek hkikkstkqa
     2221 fagqvdldll rcqqlklyil kagrallshq dklrqilsqp avqetgtvht ddgavvspdl
     2281 gdmspegpqp pmillqqlla satqpspvka ifdkqeleaa alavcqclav esthpsspgf
     2341 edcssseatt pvavqhirpa rvkrrkqspv palpivvqlm emgfsrrnie falksltgas
     2401 gnasslpgve alvgwlldhs diqvtelsda dtvsdeysde evvedvddaa ysmstgavvt
     2461 esqtykkrad flsnddyavy vreniqvgmm vrccrayeev cegdvgkvik ldrdglhdln
     2521 vqcdwqqkgg tywvryihve ligypppsss shikigdkvr vkasvttpky kwgsvthqsv
     2581 gvvkafsang kdiivdfpqq shwtgllsem elvpsihpgv tcdgcqmfpi ngsrfkcrnc
     2641 ddfdfcetcf ktkkhntrht fgrinepgqs avfcgrsgkq lkrchssqpg mlldswsrmv
     2701 kslnvsssvn qasrlidgse pcwqssgsqg khwirleifp dvlvhrlkmi vdpadssymp
     2761 slvvvsggns lnnlielkti ninpsdttvp llndcteyhr yieiaikqcr ssgidckihg
     2821 lillgrirae eedlaavpfl asdneeeede kgnsgslirk kaaglesaat irtkvfvwgl
     2881 ndkdqlgglk gskikvpsfs etlsalnvvq vaggskslfa vtvegkvyac geatngrlgl
     2941 gissgtvpip rqitalssyv vkkvavhsgg rhataltvdg kvfswgegdd gklghfsrmn
     3001 cdkprlieal ktkrirdiac gsshsaalts sgelytwglg eygrlghgdn ttqlkpkmvk
     3061 vllghrviqv acgsrdaqtl altdeglvfs wgdgdfgklg rggsegcnip qnierlngqg
     3121 vcqiecgaqf slaltksgvv wtwgkgdyfr lghgsdvhvr kpqvveglrg kkivhvavga
     3181 lhclavtdsg qvyawgdndh gqqgngtttv nrkptlvqgl egqkitrvac gsshsvawtt
     3241 vdvatpsvhe pvlfqtardp lgasylgvps dadssaasnk isgasnskpn rpslakills
     3301 ldgnlakqqa lshiltalqi myardavvga lmpaamiapv ecpsfssaap sdasamaspm
     3361 ngeecmlavd iedrlspnpw qekreivsse davtpsavtp sapsasarpf ipvtddlgaa
     3421 siiaetmtkt kedvesqnka agpepqalde ftslliaddt rvvvdllkls vcsragdrgr
     3481 dvlsavlsgm gtaypqvadm llelcvtele dvatdsqsgr lssqpvvves shpytddtst
     3541 sgtvkipgae glrvefdrqc sterrhdplt vmdgvnrivs vrsgrewsdw sselripgde
     3601 lkwkfisdgs vngwgwrftv ypimpaagpk ellsdrcvls cpsmdlvtcl ldfrlnlasn
     3661 rsivprlaas laacaqlsal aashrmwalq rlrkllttef gqsininrll gendgetral
     3721 sftgsalaal vkglpealqr qfeyedpivr ggkqllhspf fkvlvalacd leldtlpcca
     3781 ethkwawfrr ycmasrvava ldkrtplprl fldevakkir elmadsenmd vlheshdifk
     3841 reqdeqlvqw mnrrpddwtl saggsgtiyg wghnhrgqlg giegakvkvp tpcealatlr
     3901 pvqliggeqt lfavtadgkl yatgygaggr lgiggtesvs tptllesiqh vfikkvavns
     3961 ggkhclalss egevyswgea edgklghgnr spcdrprvie slrgievvdv aaggahsacv
     4021 taagdlytwg kgrygrlghs dsedqlkpkl vealqghrvv diacgsgdaq tlcltdddtv
     4081 wswgdgdygk lgrggsdgck vpmkidsltg lgvvkvecgs qfsvaltksg avytwgkgdy
     4141 hrlghgsddh vrrprqvqgl qgkkviaiat gslhcvccte dgevytwgdn degqlgdgtt
     4201 naiqrprlva alqgkkvnrv acgsahtlaw stskpasagk lpaqvpmeyn hlqeipiial
     4261 rnrllllhhl selfcpcipm fdlegsldet glgpsvgfdt lrgilisqgk eaafrkvvqa
     4321 tmvrdrqhgp vvelnriqvk rsrskgglag pdgtksvfgq mcakmssfgp dslllphrvw
     4381 kvkfvgesvd dcgggysesi aeiceelqng ltpllivtpn grdesganrd cyllspaara
     4441 pvhssmfrfl gvllgiairt gsplslnlae pvwkqlagms ltiadlsevd kdfipglmyi
     4501 rdneatseef eamslpftvp sasgqdiqls skhthitldn raeyvrlain yrlhefdeqv
     4561 aavregmarv vpvpllslft gyeletmvcg spdiplhllk svatykgiep sasliqwfwe
     4621 vmesfsnter slflrfvwgr trlprtiadf rgrdfviqvl dkynppdhfl pesytcffll
     4681 klprysckqv leeklkyaih fcksidtddy arialtgepa addssddsdn edvdsfasds
     4741 tqdyltgh
//
LOCUS       XP_047289163            4673 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase HERC2 isoform X5 [Homo sapiens].
ACCESSION   XP_047289163
VERSION     XP_047289163.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433207.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4673
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4673
                     /product="E3 ubiquitin-protein ligase HERC2 isoform X5"
                     /calculated_mol_wt=508868
     Region          293..614
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          1050..1121
                     /region_name="Cyt-b5"
                     /note="Cytochrome b5-like Heme/Steroid binding domain;
                     pfam00173"
                     /db_xref="CDD:459698"
     Region          1709..1769
                     /region_name="MIB_HERC2"
                     /note="Mib_herc2; pfam06701"
                     /db_xref="CDD:461991"
     Region          2299..2346
                     /region_name="UBA_HERC2"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC2 and similar proteins; cd14402"
                     /db_xref="CDD:270585"
     Region          2393..2470
                     /region_name="Cul7"
                     /note="Mouse development and cellular proliferation
                     protein Cullin-7; pfam11515"
                     /db_xref="CDD:463286"
     Region          2478..2535
                     /region_name="SH3_15"
                     /note="Mind bomb SH3 repeat domain; pfam18346"
                     /db_xref="CDD:465720"
     Region          2545..2589
                     /region_name="ZZ_HERC2"
                     /note="Zinc finger, ZZ type. Zinc finger present in HERC2
                     and related proteins. HERC2 is a potential E3 ubiquitin
                     protein ligase and/or guanine nucleotide exchange factor.
                     The ZZ motif coordinates two zinc ions and most likely
                     participates in ligand binding or...; cd02344"
                     /db_xref="CDD:239084"
     Site            order(2547,2550,2562,2565,2571,2574,2580,2584)
                     /site_type="other"
                     /note="Zinc-binding sites [ion binding]"
                     /db_xref="CDD:239084"
     Site            order(2547,2550,2571,2574)
                     /site_type="other"
                     /note="zinc cluster 1 [ion binding]"
                     /db_xref="CDD:239084"
     Site            order(2548,2559,2561,2567,2569)
                     /site_type="active"
                     /note="putative charged binding surface [active]"
                     /db_xref="CDD:239084"
     Site            order(2560,2575,2586,2589)
                     /site_type="active"
                     /note="putative hydrophobic binding surface [active]"
                     /db_xref="CDD:239084"
     Site            order(2562,2565,2580,2584)
                     /site_type="other"
                     /note="zinc cluster 2 [ion binding]"
                     /db_xref="CDD:239084"
     Region          2604..2749
                     /region_name="APC10-HERC2"
                     /note="APC10-like DOC1 domain present in HERC2 (HECT
                     domain and RLD2); cd08664"
                     /db_xref="CDD:176485"
     Site            order(2647,2675,2681,2683,2742)
                     /site_type="other"
                     /note="putative ligand binding site [chemical binding]"
                     /db_xref="CDD:176485"
     Region          2787..3140
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          3783..4131
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          4260..4631
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4266,4312,4323,4390,4561,4595..4596,4599..4603,4623,
                     4630)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4418,4421..4422,4424..4425,4428,4435,4438..4439,
                     4441,4447,4452,4469,4473)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4673
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /coded_by="XM_047433207.1:99..14120"
                     /db_xref="GeneID:8924"
                     /db_xref="HGNC:HGNC:4868"
                     /db_xref="MIM:605837"
ORIGIN      
        1 msklsgkaav flcllwtkks srpagkgveg larvgsraal sfafaflrra wrsgedadlc
       61 sellqeslda lralpeaslf destvssvwl evveratrfl rsvvtgdvhg tpatkgpgsi
      121 plqdqhlala illelavqrg tlsqmlsail lllqlwdsga qetdnersaq gtsapllpll
      181 qrfqsiicrk daphsegdmh llsgplspne sflryltlpq dnelaidlrq tavvvmahld
      241 rlatpcmppl cssptshkgs lqevigwgli gwkyyanvig piqceglanl gvtqiacaek
      301 rflilsrngr vytqaynsdt lapqlvqgla srnivkiaah sdghhylala atgevyswgc
      361 gdggrlghgd tvpleepkvi safsgkqagk hvvhiacgst ysaaitaege lytwgrgnyg
      421 rlghgssede aipmlvaglk glkvidvacg sgdaqtlavt engqvwswgd gdygklgrgg
      481 sdgcktpkli eklqdldvvk vrcgsqfsia ltkdgqvysw gkgdnqrlgh gteehvrypk
      541 lleglqgkkv idvaagsthc laltedsevh swgsndqcqh fdtlrvtkpe paalpgldtk
      601 hivgiacgpa qsfawsscse wsiglrvpfv vdicsmtfeq ldlllrqvse gmdgsadwpp
      661 pqekecvava tlnllrlqlh aaishqvdpe flglglgsil lnslkqtvvt lassagvlst
      721 vqsaaqavlq sgwsvllpta eeraralsal lpcavsgnev nispgrrfmi dllvgslmad
      781 gglesalhaa itaeiqdiea kkeaqkekei deqeanastf hrsrtpldkd lintgicess
      841 gkqclplvql iqqllrnias qtvarlkdva rrisscldfe qhsrersasl dlllrfqrll
      901 isklypgesi gqtsdisspe lmgvgsllkk ytallcthig dilpvaasia stswrhfaev
      961 ayivegdftg vllpelvvsi vlllsknagl mqeagavpll ggllehldrf nhlapgkerd
     1021 dheelawpgi mesfftgqnc rnneevtlir kadlenhnkd ggfwtvidgk vydikdfqtq
     1081 sltgnsilaq fagedpvval eaalqfedtr esmhafcvgq ylepdqeivt ipdlgslssp
     1141 lidternlgl llglhasyla mstplspvei ecakwlqssi fsgglqtsqi hysyneekde
     1201 dhcsspggtp asksrlcshr ralgdhsqaf lqaiadnniq dhnvkdflcq ierycrqchl
     1261 ttpimfppeh pveevgrlll ccllkhedlg hvalslvhag algieqvkhr tlpksvvdvc
     1321 rvvyqakcsl ikthqeqgrs ykevcapvie rlrflfnelr pavcndlsim skfkllsslp
     1381 rwrriaqkii rerrkkrvpk kpestddeek igneesdlee acilphspin vdkrpiaiks
     1441 pkdkwqplls tvtgvhkykw lkqnvqglyp qspllstiae falkeepvdv ekmrkcllkq
     1501 leraevrleg idtilklask nfllpsvqya mfcgwqrlip egidigeplt dclkdvdlip
     1561 pfnrmllevt fgklyawavq nirnvlmdas akfkelgiqp vplqtitnen psgpslgtip
     1621 qarfllvmls mltlqhgann ldlllnsgml altqtalrli gpscdnveed mnasaqgasa
     1681 tvleetrket apvqlpvsgp elaammkigt rvmrgvdwkw gdqdgpppgl grvigelged
     1741 gwirvqwdtg stnsyrmgke gkydlklael paaaqpsaed sdteddseae qternihpta
     1801 mmftstinll qtlclsagvh aeimqseatk tlcgllrmlv esgttdktss pnrlvyreqh
     1861 rswctlgfvr sialtpqvcg alsspqwitl lmkvveghap ftatslqrqi lavhllqavl
     1921 pswdkterar dmkclveklf dflgsllttc ssdvpllres tlrrrrvrpq asltathsst
     1981 laeevvallr tlhsltqwng linkyinsql rsithsfvgr psegaqledy fpdsenpevg
     2041 glmavlavig gidgrlrlgg qvmhdefgeg tvtritpkgk itvqfsdmrt crvcplnqlk
     2101 plpavafnvn nlpftepmls vwaqlvnlag sklekhkikk stkqafagqv dldllrcqql
     2161 klyilkagra llshqdklrq ilsqpavqet gtvhtddgav vspdlgdmsp egpqppmill
     2221 qqllasatqp spvkaifdkq eleaaalavc qclavesthp sspgfedcss seattpvavq
     2281 hirparvkrr kqspvpalpi vvqlmemgfs rrniefalks ltgasgnass lpgvealvgw
     2341 lldhsdiqvt elsdadtvsd eysdeevved vddaaysmst gavvtesqty kkradflsnd
     2401 dyavyvreni qvgmmvrccr ayeevcegdv gkvikldrdg lhdlnvqcdw qqkggtywvr
     2461 yihveligyp ppsssshiki gdkvrvkasv ttpkykwgsv thqsvgvvka fsangkdiiv
     2521 dfpqqshwtg llsemelvps ihpgvtcdgc qmfpingsrf kcrncddfdf cetcfktkkh
     2581 ntrhtfgrin epgqsavfcg rsgkqlkrch ssqpgmllds wsrmvkslnv sssvnqasrl
     2641 idgsepcwqs sgsqgkhwir leifpdvlvh rlkmivdpad ssympslvvv sggnslnnli
     2701 elktininps dttvpllndc teyhryieia ikqcrssgid ckihglillg riraeeedla
     2761 avpflasdne eeedekgnsg slirkkaagl esaatirtkv fvwglndkdq lgglkgskik
     2821 vpsfsetlsa lnvvqvaggs kslfavtveg kvyacgeatn grlglgissg tvpiprqita
     2881 lssyvvkkva vhsggrhata ltvdgkvfsw gegddgklgh fsrmncdkpr liealktkri
     2941 rdiacgsshs aaltssgely twglgeygrl ghgdnttqlk pkmvkvllgh rviqvacgsr
     3001 daqtlaltde glvfswgdgd fgklgrggse gcnipqnier lngqgvcqie cgaqfslalt
     3061 ksgvvwtwgk gdyfrlghgs dvhvrkpqvv eglrgkkivh vavgalhcla vtdsgqvyaw
     3121 gdndhgqqgn gtttvnrkpt lvqglegqki trvacgsshs vawttvdvat psvhepvlfq
     3181 tardplgasy lgvpsdadss aasnkisgas nskpnrpsla killsldgnl akqqalshil
     3241 talqimyard avvgalmpaa miapvecpsf ssaapsdasa maspmngeec mlavdiedrl
     3301 spnpwqekre ivssedavtp savtpsapsa sarpfipvtd dlgaasiiae tmtktkedve
     3361 sqnkaagpep qaldeftsll iaddtrvvvd llklsvcsra gdrgrdvlsa vlsgmgtayp
     3421 qvadmllelc vteledvatd sqsgrlssqp vvvesshpyt ddtstsgtvk ipgaeglrve
     3481 fdrqcsterr hdpltvmdgv nrivsvrsgr ewsdwsselr ipgdelkwkf isdgsvngwg
     3541 wrftvypimp aagpkellsd rcvlscpsmd lvtclldfrl nlasnrsivp rlaaslaaca
     3601 qlsalaashr mwalqrlrkl lttefgqsin inrllgendg etralsftgs alaalvkglp
     3661 ealqrqfeye dpivrggkql lhspffkvlv alacdleldt lpccaethkw awfrrycmas
     3721 rvavaldkrt plprlfldev akkirelmad senmdvlhes hdifkreqde qlvqwmnrrp
     3781 ddwtlsaggs gtiygwghnh rgqlggiega kvkvptpcea latlrpvqli ggeqtlfavt
     3841 adgklyatgy gaggrlgigg tesvstptll esiqhvfikk vavnsggkhc lalssegevy
     3901 swgeaedgkl ghgnrspcdr prvieslrgi evvdvaagga hsacvtaagd lytwgkgryg
     3961 rlghsdsedq lkpklvealq ghrvvdiacg sgdaqtlclt dddtvwswgd gdygklgrgg
     4021 sdgckvpmki dsltglgvvk vecgsqfsva ltksgavytw gkgdyhrlgh gsddhvrrpr
     4081 qvqglqgkkv iaiatgslhc vcctedgevy twgdndegql gdgttnaiqr prlvaalqgk
     4141 kvnrvacgsa htlawstskp asagklpaqv pmeynhlqei piialrnrll llhhlselfc
     4201 pcipmfdleg sldetglgps vgfdtlrgil isqgkeaafr kvvqatmvrd rqhgpvveln
     4261 riqvkrsrsk gglagpdgtk svfgqmcakm ssfgpdslll phrvwkvkfv gesvddcggg
     4321 ysesiaeice elqngltpll ivtpngrdes ganrdcylls paarapvhss mfrflgvllg
     4381 iairtgspls lnlaepvwkq lagmsltiad lsevdkdfip glmyirdnea tseefeamsl
     4441 pftvpsasgq diqlsskhth itldnraeyv rlainyrlhe fdeqvaavre gmarvvpvpl
     4501 lslftgyele tmvcgspdip lhllksvaty kgiepsasli qwfwevmesf snterslflr
     4561 fvwgrtrlpr tiadfrgrdf viqvldkynp pdhflpesyt cffllklpry sckqvleekl
     4621 kyaihfcksi dtddyarial tgepaaddss ddsdnedvds fasdstqdyl tgh
//
LOCUS       XP_047289164            3084 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase HERC2 isoform X6 [Homo sapiens].
ACCESSION   XP_047289164
VERSION     XP_047289164.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433208.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..3084
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..3084
                     /product="E3 ubiquitin-protein ligase HERC2 isoform X6"
                     /calculated_mol_wt=338179
     Region          454..775
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          1211..1282
                     /region_name="Cyt-b5"
                     /note="Cytochrome b5-like Heme/Steroid binding domain;
                     pfam00173"
                     /db_xref="CDD:459698"
     Region          1870..1930
                     /region_name="MIB_HERC2"
                     /note="Mib_herc2; pfam06701"
                     /db_xref="CDD:461991"
     Region          2460..2507
                     /region_name="UBA_HERC2"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC2 and similar proteins; cd14402"
                     /db_xref="CDD:270585"
     Region          2554..2631
                     /region_name="Cul7"
                     /note="Mouse development and cellular proliferation
                     protein Cullin-7; pfam11515"
                     /db_xref="CDD:463286"
     Region          2639..2696
                     /region_name="SH3_15"
                     /note="Mind bomb SH3 repeat domain; pfam18346"
                     /db_xref="CDD:465720"
     Region          2706..2750
                     /region_name="ZZ_HERC2"
                     /note="Zinc finger, ZZ type. Zinc finger present in HERC2
                     and related proteins. HERC2 is a potential E3 ubiquitin
                     protein ligase and/or guanine nucleotide exchange factor.
                     The ZZ motif coordinates two zinc ions and most likely
                     participates in ligand binding or...; cd02344"
                     /db_xref="CDD:239084"
     Site            order(2708,2711,2723,2726,2732,2735,2741,2745)
                     /site_type="other"
                     /note="Zinc-binding sites [ion binding]"
                     /db_xref="CDD:239084"
     Site            order(2708,2711,2732,2735)
                     /site_type="other"
                     /note="zinc cluster 1 [ion binding]"
                     /db_xref="CDD:239084"
     Site            order(2709,2720,2722,2728,2730)
                     /site_type="active"
                     /note="putative charged binding surface [active]"
                     /db_xref="CDD:239084"
     Site            order(2721,2736,2747,2750)
                     /site_type="active"
                     /note="putative hydrophobic binding surface [active]"
                     /db_xref="CDD:239084"
     Site            order(2723,2726,2741,2745)
                     /site_type="other"
                     /note="zinc cluster 2 [ion binding]"
                     /db_xref="CDD:239084"
     Region          2765..2910
                     /region_name="APC10-HERC2"
                     /note="APC10-like DOC1 domain present in HERC2 (HECT
                     domain and RLD2); cd08664"
                     /db_xref="CDD:176485"
     Site            order(2808,2836,2842,2844,2903)
                     /site_type="other"
                     /note="putative ligand binding site [chemical binding]"
                     /db_xref="CDD:176485"
     Region          2960..3006
                     /region_name="RCC1"
                     /note="Regulator of chromosome condensation (RCC1) repeat;
                     pfam00415"
                     /db_xref="CDD:395335"
     CDS             1..3084
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /coded_by="XM_047433208.1:137..9391"
                     /db_xref="GeneID:8924"
                     /db_xref="HGNC:HGNC:4868"
                     /db_xref="MIM:605837"
ORIGIN      
        1 mpsesfclaa qarldskwlk tdiqlaftrd glcglwnemv kdgeivytgt estqngelpp
       61 rkddsvepsg tkkedlndke kkdeeetpap iyraksilds wvwgkqpdvn elkeclsvlv
      121 keqqalavqs atttlsalrl kqrlvilery fialnrtvfq envkvkwkss gislppvdkk
      181 ssrpagkgve glarvgsraa lsfafaflrr awrsgedadl csellqesld alralpeasl
      241 fdestvssvw levveratrf lrsvvtgdvh gtpatkgpgs iplqdqhlal aillelavqr
      301 gtlsqmlsai llllqlwdsg aqetdnersa qgtsapllpl lqrfqsiicr kdaphsegdm
      361 hllsgplspn esflryltlp qdnelaidlr qtavvvmahl drlatpcmpp lcssptshkg
      421 slqevigwgl igwkyyanvi gpiqceglan lgvtqiacae krflilsrng rvytqaynsd
      481 tlapqlvqgl asrnivkiaa hsdghhylal aatgevyswg cgdggrlghg dtvpleepkv
      541 isafsgkqag khvvhiacgs tysaaitaeg elytwgrgny grlghgssed eaipmlvagl
      601 kglkvidvac gsgdaqtlav tengqvwswg dgdygklgrg gsdgcktpkl ieklqdldvv
      661 kvrcgsqfsi altkdgqvys wgkgdnqrlg hgteehvryp klleglqgkk vidvaagsth
      721 claltedsev hswgsndqcq hfdtlrvtkp epaalpgldt khivgiacgp aqsfawsscs
      781 ewsiglrvpf vvdicsmtfe qldlllrqvs egmdgsadwp ppqekecvav atlnllrlql
      841 haaishqvdp eflglglgsi llnslkqtvv tlassagvls tvqsaaqavl qsgwsvllpt
      901 aeeraralsa llpcavsgne vnispgrrfm idllvgslma dgglesalha aitaeiqdie
      961 akkeaqkeke ideqeanast fhrsrtpldk dlintgices sgkqclplvq liqqllrnia
     1021 sqtvarlkdv arrisscldf eqhsrersas ldlllrfqrl lisklypges igqtsdissp
     1081 elmgvgsllk kytallcthi gdilpvaasi astswrhfae vayivegdft gvllpelvvs
     1141 ivlllsknag lmqeagavpl lggllehldr fnhlapgker ddheelawpg imesfftgqn
     1201 crnneevtli rkadlenhnk dggfwtvidg kvydikdfqt qsltgnsila qfagedpvva
     1261 leaalqfedt resmhafcvg qylepdqeiv tipdlgslss plidternlg lllglhasyl
     1321 amstplspve iecakwlqss ifsgglqtsq ihysyneekd edhcsspggt pasksrlcsh
     1381 rralgdhsqa flqaiadnni qdhnvkdflc qierycrqch lttpimfppe hpveevgrll
     1441 lccllkhedl ghvalslvha galgieqvkh rtlpksvvdv crvvyqakcs likthqeqgr
     1501 sykevcapvi erlrflfnel rpavcndlsi mskfkllssl prwrriaqki irerrkkrvp
     1561 kkpestddee kigneesdle eacilphspi nvdkrpiaik spkdkwqpll stvtgvhkyk
     1621 wlkqnvqgly pqspllstia efalkeepvd vekmrkcllk qleraevrle gidtilklas
     1681 knfllpsvqy amfcgwqrli pegidigepl tdclkdvdli ppfnrmllev tfgklyawav
     1741 qnirnvlmda sakfkelgiq pvplqtitne npsgpslgti pqarfllvml smltlqhgan
     1801 nldlllnsgm laltqtalrl igpscdnvee dmnasaqgas atvleetrke tapvqlpvsg
     1861 pelaammkig trvmrgvdwk wgdqdgpppg lgrvigelge dgwirvqwdt gstnsyrmgk
     1921 egkydlklae lpaaaqpsae dsdteddsea eqternihpt ammftstinl lqtlclsagv
     1981 haeimqseat ktlcgllrml vesgttdkts spnrlvyreq hrswctlgfv rsialtpqvc
     2041 galsspqwit llmkvvegha pftatslqrq ilavhllqav lpswdktera rdmkclvekl
     2101 fdflgslltt cssdvpllre stlrrrrvrp qasltathss tlaeevvall rtlhsltqwn
     2161 glinkyinsq lrsithsfvg rpsegaqled yfpdsenpev gglmavlavi ggidgrlrlg
     2221 gqvmhdefge gtvtritpkg kitvqfsdmr tcrvcplnql kplpavafnv nnlpftepml
     2281 svwaqlvnla gsklekhkik kstkqafagq vdldllrcqq lklyilkagr allshqdklr
     2341 qilsqpavqe tgtvhtddga vvspdlgdms pegpqppmil lqqllasatq pspvkaifdk
     2401 qeleaaalav cqclavesth psspgfedcs sseattpvav qhirparvkr rkqspvpalp
     2461 ivvqlmemgf srrniefalk sltgasgnas slpgvealvg wlldhsdiqv telsdadtvs
     2521 deysdeevve dvddaaysms tgavvtesqt ykkradflsn ddyavyvren iqvgmmvrcc
     2581 rayeevcegd vgkvikldrd glhdlnvqcd wqqkggtywv ryihveligy pppsssshik
     2641 igdkvrvkas vttpkykwgs vthqsvgvvk afsangkdii vdfpqqshwt gllsemelvp
     2701 sihpgvtcdg cqmfpingsr fkcrncddfd fcetcfktkk hntrhtfgri nepgqsavfc
     2761 grsgkqlkrc hssqpgmlld swsrmvksln vsssvnqasr lidgsepcwq ssgsqgkhwi
     2821 rleifpdvlv hrlkmivdpa dssympslvv vsggnslnnl ielktininp sdttvpllnd
     2881 cteyhryiei aikqcrssgi dckihglill griraeeedl aavpflasdn eeeedekgns
     2941 gslirkkaag lesaatirtk vfvwglndkd qlgglkgski kvpsfsetls alnvvqvagg
     3001 skslfaespl lavvpcsdcg regvclwrsh ewpagaghfq rdgahptadh ssqqlrgqeg
     3061 gcslrwpard gfncrwksvf vgrr
//
LOCUS       XP_047289165            2713 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase HERC2 isoform X7 [Homo sapiens].
ACCESSION   XP_047289165
VERSION     XP_047289165.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433209.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2713
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2713
                     /product="E3 ubiquitin-protein ligase HERC2 isoform X7"
                     /calculated_mol_wt=297434
     Region          454..775
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          1211..1282
                     /region_name="Cyt-b5"
                     /note="Cytochrome b5-like Heme/Steroid binding domain;
                     pfam00173"
                     /db_xref="CDD:459698"
     Region          1870..1930
                     /region_name="MIB_HERC2"
                     /note="Mib_herc2; pfam06701"
                     /db_xref="CDD:461991"
     Region          2460..2507
                     /region_name="UBA_HERC2"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC2 and similar proteins; cd14402"
                     /db_xref="CDD:270585"
     Region          2554..2631
                     /region_name="Cul7"
                     /note="Mouse development and cellular proliferation
                     protein Cullin-7; pfam11515"
                     /db_xref="CDD:463286"
     CDS             1..2713
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /coded_by="XM_047433209.1:137..8278"
                     /db_xref="GeneID:8924"
                     /db_xref="HGNC:HGNC:4868"
                     /db_xref="MIM:605837"
ORIGIN      
        1 mpsesfclaa qarldskwlk tdiqlaftrd glcglwnemv kdgeivytgt estqngelpp
       61 rkddsvepsg tkkedlndke kkdeeetpap iyraksilds wvwgkqpdvn elkeclsvlv
      121 keqqalavqs atttlsalrl kqrlvilery fialnrtvfq envkvkwkss gislppvdkk
      181 ssrpagkgve glarvgsraa lsfafaflrr awrsgedadl csellqesld alralpeasl
      241 fdestvssvw levveratrf lrsvvtgdvh gtpatkgpgs iplqdqhlal aillelavqr
      301 gtlsqmlsai llllqlwdsg aqetdnersa qgtsapllpl lqrfqsiicr kdaphsegdm
      361 hllsgplspn esflryltlp qdnelaidlr qtavvvmahl drlatpcmpp lcssptshkg
      421 slqevigwgl igwkyyanvi gpiqceglan lgvtqiacae krflilsrng rvytqaynsd
      481 tlapqlvqgl asrnivkiaa hsdghhylal aatgevyswg cgdggrlghg dtvpleepkv
      541 isafsgkqag khvvhiacgs tysaaitaeg elytwgrgny grlghgssed eaipmlvagl
      601 kglkvidvac gsgdaqtlav tengqvwswg dgdygklgrg gsdgcktpkl ieklqdldvv
      661 kvrcgsqfsi altkdgqvys wgkgdnqrlg hgteehvryp klleglqgkk vidvaagsth
      721 claltedsev hswgsndqcq hfdtlrvtkp epaalpgldt khivgiacgp aqsfawsscs
      781 ewsiglrvpf vvdicsmtfe qldlllrqvs egmdgsadwp ppqekecvav atlnllrlql
      841 haaishqvdp eflglglgsi llnslkqtvv tlassagvls tvqsaaqavl qsgwsvllpt
      901 aeeraralsa llpcavsgne vnispgrrfm idllvgslma dgglesalha aitaeiqdie
      961 akkeaqkeke ideqeanast fhrsrtpldk dlintgices sgkqclplvq liqqllrnia
     1021 sqtvarlkdv arrisscldf eqhsrersas ldlllrfqrl lisklypges igqtsdissp
     1081 elmgvgsllk kytallcthi gdilpvaasi astswrhfae vayivegdft gvllpelvvs
     1141 ivlllsknag lmqeagavpl lggllehldr fnhlapgker ddheelawpg imesfftgqn
     1201 crnneevtli rkadlenhnk dggfwtvidg kvydikdfqt qsltgnsila qfagedpvva
     1261 leaalqfedt resmhafcvg qylepdqeiv tipdlgslss plidternlg lllglhasyl
     1321 amstplspve iecakwlqss ifsgglqtsq ihysyneekd edhcsspggt pasksrlcsh
     1381 rralgdhsqa flqaiadnni qdhnvkdflc qierycrqch lttpimfppe hpveevgrll
     1441 lccllkhedl ghvalslvha galgieqvkh rtlpksvvdv crvvyqakcs likthqeqgr
     1501 sykevcapvi erlrflfnel rpavcndlsi mskfkllssl prwrriaqki irerrkkrvp
     1561 kkpestddee kigneesdle eacilphspi nvdkrpiaik spkdkwqpll stvtgvhkyk
     1621 wlkqnvqgly pqspllstia efalkeepvd vekmrkcllk qleraevrle gidtilklas
     1681 knfllpsvqy amfcgwqrli pegidigepl tdclkdvdli ppfnrmllev tfgklyawav
     1741 qnirnvlmda sakfkelgiq pvplqtitne npsgpslgti pqarfllvml smltlqhgan
     1801 nldlllnsgm laltqtalrl igpscdnvee dmnasaqgas atvleetrke tapvqlpvsg
     1861 pelaammkig trvmrgvdwk wgdqdgpppg lgrvigelge dgwirvqwdt gstnsyrmgk
     1921 egkydlklae lpaaaqpsae dsdteddsea eqternihpt ammftstinl lqtlclsagv
     1981 haeimqseat ktlcgllrml vesgttdkts spnrlvyreq hrswctlgfv rsialtpqvc
     2041 galsspqwit llmkvvegha pftatslqrq ilavhllqav lpswdktera rdmkclvekl
     2101 fdflgslltt cssdvpllre stlrrrrvrp qasltathss tlaeevvall rtlhsltqwn
     2161 glinkyinsq lrsithsfvg rpsegaqled yfpdsenpev gglmavlavi ggidgrlrlg
     2221 gqvmhdefge gtvtritpkg kitvqfsdmr tcrvcplnql kplpavafnv nnlpftepml
     2281 svwaqlvnla gsklekhkik kstkqafagq vdldllrcqq lklyilkagr allshqdklr
     2341 qilsqpavqe tgtvhtddga vvspdlgdms pegpqppmil lqqllasatq pspvkaifdk
     2401 qeleaaalav cqclavesth psspgfedcs sseattpvav qhirparvkr rkqspvpalp
     2461 ivvqlmemgf srrniefalk sltgasgnas slpgvealvg wlldhsdiqv telsdadtvs
     2521 deysdeevve dvddaaysms tgavvtesqt ykkradflsn ddyavyvren iqvgmmvrcc
     2581 rayeevcegd vgkvikldrd glhdlnvqcd wqqkggtywv ryihveligy pppsssshik
     2641 igdkvrvkas vttpkykwgs vthqsvgvvk gvmdvrcfls mdpdsnaetv mtlifvkrvs
     2701 rpkntipgih lae
//
LOCUS       XP_016878186            2556 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase HERC2 isoform X8 [Homo sapiens].
ACCESSION   XP_016878186
VERSION     XP_016878186.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022697.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2556
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2556
                     /product="E3 ubiquitin-protein ligase HERC2 isoform X8"
                     /calculated_mol_wt=277194
     Region          182..229
                     /region_name="UBA_HERC2"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC2 and similar proteins; cd14402"
                     /db_xref="CDD:270585"
     Region          276..353
                     /region_name="Cul7"
                     /note="Mouse development and cellular proliferation
                     protein Cullin-7; pfam11515"
                     /db_xref="CDD:463286"
     Region          361..418
                     /region_name="SH3_15"
                     /note="Mind bomb SH3 repeat domain; pfam18346"
                     /db_xref="CDD:465720"
     Region          428..472
                     /region_name="ZZ_HERC2"
                     /note="Zinc finger, ZZ type. Zinc finger present in HERC2
                     and related proteins. HERC2 is a potential E3 ubiquitin
                     protein ligase and/or guanine nucleotide exchange factor.
                     The ZZ motif coordinates two zinc ions and most likely
                     participates in ligand binding or...; cd02344"
                     /db_xref="CDD:239084"
     Site            order(430,433,445,448,454,457,463,467)
                     /site_type="other"
                     /note="Zinc-binding sites [ion binding]"
                     /db_xref="CDD:239084"
     Site            order(430,433,454,457)
                     /site_type="other"
                     /note="zinc cluster 1 [ion binding]"
                     /db_xref="CDD:239084"
     Site            order(431,442,444,450,452)
                     /site_type="active"
                     /note="putative charged binding surface [active]"
                     /db_xref="CDD:239084"
     Site            order(443,458,469,472)
                     /site_type="active"
                     /note="putative hydrophobic binding surface [active]"
                     /db_xref="CDD:239084"
     Site            order(445,448,463,467)
                     /site_type="other"
                     /note="zinc cluster 2 [ion binding]"
                     /db_xref="CDD:239084"
     Region          487..632
                     /region_name="APC10-HERC2"
                     /note="APC10-like DOC1 domain present in HERC2 (HECT
                     domain and RLD2); cd08664"
                     /db_xref="CDD:176485"
     Site            order(530,558,564,566,625)
                     /site_type="other"
                     /note="putative ligand binding site [chemical binding]"
                     /db_xref="CDD:176485"
     Region          670..1023
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          1666..2014
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          2143..2514
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(2149,2195,2206,2273,2444,2478..2479,2482..2486,2506,
                     2513)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(2301,2304..2305,2307..2308,2311,2318,2321..2322,
                     2324,2330,2335,2352,2356)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..2556
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /coded_by="XM_017022697.2:274..7944"
                     /db_xref="GeneID:8924"
                     /db_xref="HGNC:HGNC:4868"
                     /db_xref="MIM:605837"
ORIGIN      
        1 mlsvwaqlvn lagsklekhk ikkstkqafa gqvdldllrc qqlklyilka grallshqdk
       61 lrqilsqpav qetgtvhtdd gavvspdlgd mspegpqppm illqqllasa tqpspvkaif
      121 dkqeleaaal avcqclaves thpsspgfed cssseattpv avqhirparv krrkqspvpa
      181 lpivvqlmem gfsrrniefa lksltgasgn asslpgveal vgwlldhsdi qvtelsdadt
      241 vsdeysdeev vedvddaays mstgavvtes qtykkradfl snddyavyvr eniqvgmmvr
      301 ccrayeevce gdvgkvikld rdglhdlnvq cdwqqkggty wvryihveli gypppssssh
      361 ikigdkvrvk asvttpkykw gsvthqsvgv vkafsangkd iivdfpqqsh wtgllsemel
      421 vpsihpgvtc dgcqmfping srfkcrncdd fdfcetcfkt kkhntrhtfg rinepgqsav
      481 fcgrsgkqlk rchssqpgml ldswsrmvks lnvsssvnqa srlidgsepc wqssgsqgkh
      541 wirleifpdv lvhrlkmivd padssympsl vvvsggnsln nlielktini npsdttvpll
      601 ndcteyhryi eiaikqcrss gidckihgli llgriraeee dlaavpflas dneeeedekg
      661 nsgslirkka aglesaatir tkvfvwglnd kdqlgglkgs kikvpsfset lsalnvvqva
      721 ggskslfavt vegkvyacge atngrlglgi ssgtvpiprq italssyvvk kvavhsggrh
      781 ataltvdgkv fswgegddgk lghfsrmncd kprliealkt krirdiacgs shsaaltssg
      841 elytwglgey grlghgdntt qlkpkmvkvl lghrviqvac gsrdaqtlal tdeglvfswg
      901 dgdfgklgrg gsegcnipqn ierlngqgvc qiecgaqfsl altksgvvwt wgkgdyfrlg
      961 hgsdvhvrkp qvveglrgkk ivhvavgalh clavtdsgqv yawgdndhgq qgngtttvnr
     1021 kptlvqgleg qkitrvacgs shsvawttvd vatpsvhepv lfqtardplg asylgvpsda
     1081 dssaasnkis gasnskpnrp slakillsld gnlakqqals hiltalqimy ardavvgalm
     1141 paamiapvec psfssaapsd asamaspmng eecmlavdie drlspnpwqe kreivsseda
     1201 vtpsavtpsa psasarpfip vtddlgaasi iaetmtktke dvesqnkaag pepqaldeft
     1261 slliaddtrv vvdllklsvc sragdrgrdv lsavlsgmgt aypqvadmll elcvteledv
     1321 atdsqsgrls sqpvvvessh pytddtstsg tvkipgaegl rvefdrqcst errhdpltvm
     1381 dgvnrivsvr sgrewsdwss elripgdelk wkfisdgsvn gwgwrftvyp impaagpkel
     1441 lsdrcvlscp smdlvtclld frlnlasnrs ivprlaasla acaqlsalaa shrmwalqrl
     1501 rkllttefgq sininrllge ndgetralsf tgsalaalvk glpealqrqf eyedpivrgg
     1561 kqllhspffk vlvalacdle ldtlpccaet hkwawfrryc masrvavald krtplprlfl
     1621 devakkirel madsenmdvl heshdifkre qdeqlvqwmn rrpddwtlsa ggsgtiygwg
     1681 hnhrgqlggi egakvkvptp cealatlrpv qliggeqtlf avtadgklya tgygaggrlg
     1741 iggtesvstp tllesiqhvf ikkvavnsgg khclalsseg evyswgeaed gklghgnrsp
     1801 cdrprviesl rgievvdvaa ggahsacvta agdlytwgkg rygrlghsds edqlkpklve
     1861 alqghrvvdi acgsgdaqtl cltdddtvws wgdgdygklg rggsdgckvp mkidsltglg
     1921 vvkvecgsqf svaltksgav ytwgkgdyhr lghgsddhvr rprqvqglqg kkviaiatgs
     1981 lhcvcctedg evytwgdnde gqlgdgttna iqrprlvaal qgkkvnrvac gsahtlawst
     2041 skpasagklp aqvpmeynhl qeipiialrn rllllhhlse lfcpcipmfd legsldetgl
     2101 gpsvgfdtlr gilisqgkea afrkvvqatm vrdrqhgpvv elnriqvkrs rskgglagpd
     2161 gtksvfgqmc akmssfgpds lllphrvwkv kfvgesvddc gggysesiae iceelqnglt
     2221 pllivtpngr desganrdcy llspaarapv hssmfrflgv llgiairtgs plslnlaepv
     2281 wkqlagmslt iadlsevdkd fipglmyird neatseefea mslpftvpsa sgqdiqlssk
     2341 hthitldnra eyvrlainyr lhefdeqvaa vregmarvvp vpllslftgy eletmvcgsp
     2401 diplhllksv atykgiepsa sliqwfwevm esfsntersl flrfvwgrtr lprtiadfrg
     2461 rdfviqvldk ynppdhflpe sytcffllkl prysckqvle eklkyaihfc ksidtddyar
     2521 ialtgepaad dssddsdned vdsfasdstq dyltgh
//
LOCUS       XP_016878187            2556 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase HERC2 isoform X8 [Homo sapiens].
ACCESSION   XP_016878187
VERSION     XP_016878187.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022698.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2556
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..2556
                     /product="E3 ubiquitin-protein ligase HERC2 isoform X8"
                     /calculated_mol_wt=277194
     Region          182..229
                     /region_name="UBA_HERC2"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC2 and similar proteins; cd14402"
                     /db_xref="CDD:270585"
     Region          276..353
                     /region_name="Cul7"
                     /note="Mouse development and cellular proliferation
                     protein Cullin-7; pfam11515"
                     /db_xref="CDD:463286"
     Region          361..418
                     /region_name="SH3_15"
                     /note="Mind bomb SH3 repeat domain; pfam18346"
                     /db_xref="CDD:465720"
     Region          428..472
                     /region_name="ZZ_HERC2"
                     /note="Zinc finger, ZZ type. Zinc finger present in HERC2
                     and related proteins. HERC2 is a potential E3 ubiquitin
                     protein ligase and/or guanine nucleotide exchange factor.
                     The ZZ motif coordinates two zinc ions and most likely
                     participates in ligand binding or...; cd02344"
                     /db_xref="CDD:239084"
     Site            order(430,433,445,448,454,457,463,467)
                     /site_type="other"
                     /note="Zinc-binding sites [ion binding]"
                     /db_xref="CDD:239084"
     Site            order(430,433,454,457)
                     /site_type="other"
                     /note="zinc cluster 1 [ion binding]"
                     /db_xref="CDD:239084"
     Site            order(431,442,444,450,452)
                     /site_type="active"
                     /note="putative charged binding surface [active]"
                     /db_xref="CDD:239084"
     Site            order(443,458,469,472)
                     /site_type="active"
                     /note="putative hydrophobic binding surface [active]"
                     /db_xref="CDD:239084"
     Site            order(445,448,463,467)
                     /site_type="other"
                     /note="zinc cluster 2 [ion binding]"
                     /db_xref="CDD:239084"
     Region          487..632
                     /region_name="APC10-HERC2"
                     /note="APC10-like DOC1 domain present in HERC2 (HECT
                     domain and RLD2); cd08664"
                     /db_xref="CDD:176485"
     Site            order(530,558,564,566,625)
                     /site_type="other"
                     /note="putative ligand binding site [chemical binding]"
                     /db_xref="CDD:176485"
     Region          670..1023
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          1666..2014
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          2143..2514
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(2149,2195,2206,2273,2444,2478..2479,2482..2486,2506,
                     2513)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(2301,2304..2305,2307..2308,2311,2318,2321..2322,
                     2324,2330,2335,2352,2356)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..2556
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /coded_by="XM_017022698.2:187..7857"
                     /db_xref="GeneID:8924"
                     /db_xref="HGNC:HGNC:4868"
                     /db_xref="MIM:605837"
ORIGIN      
        1 mlsvwaqlvn lagsklekhk ikkstkqafa gqvdldllrc qqlklyilka grallshqdk
       61 lrqilsqpav qetgtvhtdd gavvspdlgd mspegpqppm illqqllasa tqpspvkaif
      121 dkqeleaaal avcqclaves thpsspgfed cssseattpv avqhirparv krrkqspvpa
      181 lpivvqlmem gfsrrniefa lksltgasgn asslpgveal vgwlldhsdi qvtelsdadt
      241 vsdeysdeev vedvddaays mstgavvtes qtykkradfl snddyavyvr eniqvgmmvr
      301 ccrayeevce gdvgkvikld rdglhdlnvq cdwqqkggty wvryihveli gypppssssh
      361 ikigdkvrvk asvttpkykw gsvthqsvgv vkafsangkd iivdfpqqsh wtgllsemel
      421 vpsihpgvtc dgcqmfping srfkcrncdd fdfcetcfkt kkhntrhtfg rinepgqsav
      481 fcgrsgkqlk rchssqpgml ldswsrmvks lnvsssvnqa srlidgsepc wqssgsqgkh
      541 wirleifpdv lvhrlkmivd padssympsl vvvsggnsln nlielktini npsdttvpll
      601 ndcteyhryi eiaikqcrss gidckihgli llgriraeee dlaavpflas dneeeedekg
      661 nsgslirkka aglesaatir tkvfvwglnd kdqlgglkgs kikvpsfset lsalnvvqva
      721 ggskslfavt vegkvyacge atngrlglgi ssgtvpiprq italssyvvk kvavhsggrh
      781 ataltvdgkv fswgegddgk lghfsrmncd kprliealkt krirdiacgs shsaaltssg
      841 elytwglgey grlghgdntt qlkpkmvkvl lghrviqvac gsrdaqtlal tdeglvfswg
      901 dgdfgklgrg gsegcnipqn ierlngqgvc qiecgaqfsl altksgvvwt wgkgdyfrlg
      961 hgsdvhvrkp qvveglrgkk ivhvavgalh clavtdsgqv yawgdndhgq qgngtttvnr
     1021 kptlvqgleg qkitrvacgs shsvawttvd vatpsvhepv lfqtardplg asylgvpsda
     1081 dssaasnkis gasnskpnrp slakillsld gnlakqqals hiltalqimy ardavvgalm
     1141 paamiapvec psfssaapsd asamaspmng eecmlavdie drlspnpwqe kreivsseda
     1201 vtpsavtpsa psasarpfip vtddlgaasi iaetmtktke dvesqnkaag pepqaldeft
     1261 slliaddtrv vvdllklsvc sragdrgrdv lsavlsgmgt aypqvadmll elcvteledv
     1321 atdsqsgrls sqpvvvessh pytddtstsg tvkipgaegl rvefdrqcst errhdpltvm
     1381 dgvnrivsvr sgrewsdwss elripgdelk wkfisdgsvn gwgwrftvyp impaagpkel
     1441 lsdrcvlscp smdlvtclld frlnlasnrs ivprlaasla acaqlsalaa shrmwalqrl
     1501 rkllttefgq sininrllge ndgetralsf tgsalaalvk glpealqrqf eyedpivrgg
     1561 kqllhspffk vlvalacdle ldtlpccaet hkwawfrryc masrvavald krtplprlfl
     1621 devakkirel madsenmdvl heshdifkre qdeqlvqwmn rrpddwtlsa ggsgtiygwg
     1681 hnhrgqlggi egakvkvptp cealatlrpv qliggeqtlf avtadgklya tgygaggrlg
     1741 iggtesvstp tllesiqhvf ikkvavnsgg khclalsseg evyswgeaed gklghgnrsp
     1801 cdrprviesl rgievvdvaa ggahsacvta agdlytwgkg rygrlghsds edqlkpklve
     1861 alqghrvvdi acgsgdaqtl cltdddtvws wgdgdygklg rggsdgckvp mkidsltglg
     1921 vvkvecgsqf svaltksgav ytwgkgdyhr lghgsddhvr rprqvqglqg kkviaiatgs
     1981 lhcvcctedg evytwgdnde gqlgdgttna iqrprlvaal qgkkvnrvac gsahtlawst
     2041 skpasagklp aqvpmeynhl qeipiialrn rllllhhlse lfcpcipmfd legsldetgl
     2101 gpsvgfdtlr gilisqgkea afrkvvqatm vrdrqhgpvv elnriqvkrs rskgglagpd
     2161 gtksvfgqmc akmssfgpds lllphrvwkv kfvgesvddc gggysesiae iceelqnglt
     2221 pllivtpngr desganrdcy llspaarapv hssmfrflgv llgiairtgs plslnlaepv
     2281 wkqlagmslt iadlsevdkd fipglmyird neatseefea mslpftvpsa sgqdiqlssk
     2341 hthitldnra eyvrlainyr lhefdeqvaa vregmarvvp vpllslftgy eletmvcgsp
     2401 diplhllksv atykgiepsa sliqwfwevm esfsntersl flrfvwgrtr lprtiadfrg
     2461 rdfviqvldk ynppdhflpe sytcffllkl prysckqvle eklkyaihfc ksidtddyar
     2521 ialtgepaad dssddsdned vdsfasdstq dyltgh
//
LOCUS       XP_047289166            4909 aa            linear   PRI 05-AUG-2025
DEFINITION  putative E3 ubiquitin-protein ligase HERC1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_047289166
VERSION     XP_047289166.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433210.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4909
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4909
                     /product="putative E3 ubiquitin-protein ligase HERC1
                     isoform X1"
                     /calculated_mol_wt=537522
     Region          374..703
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          683..733
                     /region_name="RCC1"
                     /note="Regulator of chromosome condensation (RCC1) repeat;
                     pfam00415"
                     /db_xref="CDD:395335"
     Region          2063..2220
                     /region_name="SPRY_HERC1"
                     /note="SPRY domain in HERC1; cd12881"
                     /db_xref="CDD:293939"
     Region          2784..2827
                     /region_name="UBA_HERC1"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC1 and similar proteins; cd14401"
                     /db_xref="CDD:270584"
     Region          <3435..3826
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          3480..3523
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3537..3572
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3577..3624
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3633..3668
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3677..3713
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3720..3751
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3798..3834
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          4047..4383
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          4521..4889
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4526,4567,4578,4645,4823,4853..4854,4857..4861,4881,
                     4888)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4673,4676..4677,4679..4680,4683,4691,4693,
                     4697..4698,4700,4709,4714,4731,4735)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4909
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /coded_by="XM_047433210.1:154..14883"
                     /db_xref="GeneID:8925"
                     /db_xref="HGNC:HGNC:4867"
                     /db_xref="MIM:605109"
ORIGIN      
        1 matmippvkl kwlehlnssw itedsesiat regvavlysk lvsnkevvpl pqqvlclkgp
       61 qlpdferesl ssdeqdhyld allssqlala kmvcsdspfa galrkrllvl qrvfyalsnk
      121 yhdkgkvkqq qhspesssgs advhsvserp rsstdaliem gvrtglsllf allrqswmmp
      181 vsgpglslcn dvihtaievv sslpplslan eskippmgld clsqvttflk gvtipnsgad
      241 tlgrrlasel llglaaqrgs lryllewiem algasavvht mekgkllssq egmisfdcfm
      301 tilmqmrrsl gssadrsqwr eptrtsdglc slyeaalclf eevcrmasdy srtcaspdsi
      361 qtgdapivse tcevyvwgsn sshqlvegtq ekilqpklap sfsdaqtiea gqyctfvist
      421 dgsvracgkg sygrlglgds nnqstlkklt fephrsikkv ssskgsdght lafttegevf
      481 swgdgdygkl ghgnsstqky pkliqgplqg kvvvcvsagy rhsaavtedg elytwgegdf
      541 grlghgdsns rniptlvkdi snvgevscgs shtialskdg rtvwsfgggd ngklghgdtn
      601 rvykpkviea lqgmfirkvc agsqsslalt stgqvyawgc gaclgcgsse atalrpklie
      661 elaatrivdv sigdshclal shdnevyawg nnsmgqcgqg nstgpitkpk kvsgldgiai
      721 qqisagtshs lawtalprdr qvvawhrpyc vdleestfsh lrsflerycd kinseipplp
      781 fpssrehhsf lklclkllsn hlalalaggv atsilgrqag plrnllfrlm dstvpdeiqe
      841 vvietlsvga tmllpplrer mellhsllpq gpdrweslsk gqrmqldiil tslqdhthva
      901 sllgysspsd aadlssvctg ygnlsdqpyg tqschpdthl aeilmktllr nlgfytdqaf
      961 geleknsdkf llgtsssens qpahlhellc slqkqllafc hinnisenss svallhkhlq
     1021 lllphatdiy srsanllkes pwngsvgekl rdviyvsaag smlcqivnsl lllpvsvarp
     1081 llsylldllp pldclnrllp aadlledqel qwplhggpel idpaglplpq paqswvwlvd
     1141 lertiallig rclggmlqgs pvspeeqdta ywmktplfsd gvemdtpqld kcmsclleva
     1201 lsgneeqkpf dyklrpeiav yvdlalgcsk eparslwism qdyavskdwd satlsnesll
     1261 dtvsrfvlaa llkhtnllsq acgesryqpg khlsevyrcv ykvrsrllac knleliqtrs
     1321 ssrdrwisen qdsadvdpqe hsftrtidee aemeeqaerd reeghpeped eeeerehevm
     1381 tagnlvfvlh vteifqcfls arevarsrdr drmnsgagsg araddpppqs qqerrvstdl
     1441 pegqdvytaa cnsvihrcal lilgvspvid elqkrreegq lqqpstsase ggglmtrses
     1501 ltaesrlvht spnyrliksr sesdlsqpes deegyalsgr rnvdldlaas hrkrvylllf
     1561 gqlsprkkks fkqvhdgpmh sqleslsdsw arlkhsrdwl cnssysfesd fdltkslgvh
     1621 tlienvvsfv sgdvgnapgf kepeesmsts pqasiiameq qqlraelrle alhqilvlls
     1681 gmeekgsisl agsrlssgfq sstlltsvrl qflagcfglg tvghtggkge sgrlhhyqdg
     1741 iraakrniqi eiqvavhkiy qqlsatlera lqankhhiea qqrlllvtvf alsvhyqpvd
     1801 vslaistgll nvlsqlcgtd tmlgqplqll pktgvsqlst alkvastrll qilaittgty
     1861 adklspkvvq slldllcsql knllsqtgvl hmasfgegeq edgeeeekkv dssgetekkd
     1921 fraalrkqha aelhlgdflv flrrvvsska iqskmaspkw tevllniasq kcssgiplvg
     1981 nlrtrllalh vleavlpace sgveddqmaq iverlfslls dcmwetpiaq akhaiqikek
     2041 eqeiklqkqg eleeedenlp iqevsfdpek aqcclvengq ilthgsggkg yglastgvts
     2101 gcyqwkfyiv kenrgnegtc vgvsrwpvhd fnhrttsdmw lyraysgnly hngeqtltls
     2161 sftqgdfitc vldmeartis fgkngeepkl afedvdaael ypcvmfyssn pgekvkicdm
     2221 qmrgtprdll pgdpicspva avlaeatiql irilhrtdrw tycinkkmme rlhkikicik
     2281 esgqklkksr svqsreenem reekeskeee kgkhtrhgla dlselqlrtl cievwpvlav
     2341 iggvdaglrv ggrcvhkqtg rhatllgvvk egstsakvqw deaeitisfp tfwspsdtpl
     2401 ynlepceplp fdvarfrglt asvlldltyl tgvhedmgkq stkrhekkhr heseekgdve
     2461 qkpesesald mrtgltsddv ksqsttssks eneiasfsld ptlpsvesqh qitegkrknh
     2521 ehmsknhdva qseiravqls ylylgamksl sallgcskya elllipkvla enghnsdcas
     2581 spvvhedvem raalqflmrh mvkravmrsp ikralgladl eraqamiykl vvhglledqf
     2641 ggkikqeidq qaeesdpaqq aqtpvttsps assttsfmss sledtttatt pvtdtetvpa
     2701 sespgvmpls llrqmfssyp tttvlptrra qtppisslpt spsdevgrrq sltspdsqsa
     2761 rpanrtalsd pssrlstspp ppaiavplle mgfslrqiak ameatgarge adaqnitvla
     2821 mwmiehpghe deeepqsgst adsrpgaavl gsggksndpc ylqspgdips adaaemeegf
     2881 sespdnldht enaasgsgps argrsavtrr hkfdlaartl laraaglyrs vqahrnqsrr
     2941 egislqqdpg alydfnldee leidlddeam eamfgqdlts dndilgmwip evldwptwhv
     3001 cesedreevv vcelcecsvv sfnqhmkrnh pgcgrsanrq gyrsngsyvd gwfggecgsg
     3061 npyyllcgtc rekylamktk skstsseryk gqapdligkq dsvyeedwdm ldvdedeklt
     3121 geeefellag plglndrriv pepvqfpdsd plgasvamvt atnsmeetlm qigchgsvek
     3181 sssgritlge qaaalanphd rvvalrrvta aaqvllartm vmralsllsv sgsscslaag
     3241 leslgltdir tlvrlmclaa agraglstsp samastsers rgghskankp isclaylsta
     3301 vgclasnaps aakllvqlct qnlisaatgv nlttvddsiq rkflpsflrg iaeenklvts
     3361 pnfvvtqalv alladkgakl rpnydkseve kkgliaqlya hpsydpsavg plelanalaa
     3421 cclssrlssq hrqwaaqqlv rtlaahdrdn qttlqtladm ggdlrkcsfi kleahqnrvm
     3481 tcvwcnkkgl latsgndgti rvwnvtkkqy slqqtcvfnr legdaeeslg spsdpsfspv
     3541 swsisgkyla galekmvniw qvnggkglvd iqphwvsala wpeegpataw sgespelllv
     3601 grmdgslgli evvdvstmhr relehcyrkd vsvtciawfs edrpfavgyf dgklllgtke
     3661 plekggivli dahkdtlism kwdptghilm tcakedsvkl wgsisgcwcc lhslchpsiv
     3721 ngiawcrlpg kgsklqllma tgcqsglvcv wripqdttqt nvtsaegwwe qesncqdgyr
     3781 kssgakcvyq lrghitpvrt vafssdglal vsgglgglmn iwslrdgsvl qtvvigsgai
     3841 qttvwipevg vaacsnrskd vlvvnctaew aaanhvlatc rtalkqqgvl glnmapcmra
     3901 flerlpmmlq eqyayekphv vcgdqlvhsp ymqclaslav glhldqllcn ppvpphhqnc
     3961 lpdpaswnpn ewawlecfst tikaaealtn gaqfpesftv pdlepvpede lvflmdnskw
     4021 ingmdeqims watsrpedwh lggkcdvylw gagrhgqlae agrnvmvpaa apsfsqaqqv
     4081 icgqnctfvi qangtvlacg egsygrlgqg nsddlhvltv isalqgfvvt qlvtscgsdg
     4141 hsmaltesge vfswgdgdyg klghgnsdrq rrprqiealq geevvqmscg fkhsavvtsd
     4201 gklftfgngd ygrlglgnts nkklpervta legyqigqva cglnhtlavs adgsmvwafg
     4261 dgdygklglg nstaksspqk idvlcgigik kvacgtqfsv altkdghvyt fgqdrliglp
     4321 egrarnhnrp qqipvlagvi iedvavgaeh tlalasngdv yawgsnsegq lglghtnhvr
     4381 eptlvtglqg knvrqisagr chsaawtapp vpprapgvsv plqlglpdtv ppqygalrev
     4441 sihtvrarlr llyhfsdlmy sswrllnlsp nnqnstshyn agtwgivqgq lrpllaprvy
     4501 tlpmvrsigk tmvqgknygp qitvkristr grkckpifvq iarqvvklna sdlrlpsraw
     4561 kvklvgegad daggvfddti temcqeletg ivdllipspn ataevgynrd rflfnpsacl
     4621 dehlmqfkfl gilmgvairt kkpldlhlap lvwkqlccvp ltledleevd llyvqtlnsi
     4681 lhiedsgite esfhemipld sfvgqsadgk mvpiipggns ipltfsnrke yveraieyrl
     4741 hemdrqvaav regmswivpv pllslltakq leqmvcgmpe isvevlkkvv ryrevdeqhq
     4801 lvqwfwhtle efsneervlf mrfvsgrsrl pantadisqr fqimkvdrpy dslptsqtcf
     4861 fqlrlppyss qlvmaerlry ainncrsidm dnymlsrnvd naegsdtdy
//
LOCUS       XP_047289167            4908 aa            linear   PRI 05-AUG-2025
DEFINITION  putative E3 ubiquitin-protein ligase HERC1 isoform X2 [Homo
            sapiens].
ACCESSION   XP_047289167
VERSION     XP_047289167.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433211.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4908
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4908
                     /product="putative E3 ubiquitin-protein ligase HERC1
                     isoform X2"
                     /calculated_mol_wt=537393
     Region          374..703
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          683..733
                     /region_name="RCC1"
                     /note="Regulator of chromosome condensation (RCC1) repeat;
                     pfam00415"
                     /db_xref="CDD:395335"
     Region          2063..2220
                     /region_name="SPRY_HERC1"
                     /note="SPRY domain in HERC1; cd12881"
                     /db_xref="CDD:293939"
     Region          2784..2827
                     /region_name="UBA_HERC1"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC1 and similar proteins; cd14401"
                     /db_xref="CDD:270584"
     Region          <3434..3825
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          3479..3522
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3536..3571
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3576..3623
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3632..3667
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3676..3712
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3719..3750
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3797..3833
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          4046..4382
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          4520..4888
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4525,4566,4577,4644,4822,4852..4853,4856..4860,4880,
                     4887)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4672,4675..4676,4678..4679,4682,4690,4692,
                     4696..4697,4699,4708,4713,4730,4734)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4908
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /coded_by="XM_047433211.1:154..14880"
                     /db_xref="GeneID:8925"
                     /db_xref="HGNC:HGNC:4867"
                     /db_xref="MIM:605109"
ORIGIN      
        1 matmippvkl kwlehlnssw itedsesiat regvavlysk lvsnkevvpl pqqvlclkgp
       61 qlpdferesl ssdeqdhyld allssqlala kmvcsdspfa galrkrllvl qrvfyalsnk
      121 yhdkgkvkqq qhspesssgs advhsvserp rsstdaliem gvrtglsllf allrqswmmp
      181 vsgpglslcn dvihtaievv sslpplslan eskippmgld clsqvttflk gvtipnsgad
      241 tlgrrlasel llglaaqrgs lryllewiem algasavvht mekgkllssq egmisfdcfm
      301 tilmqmrrsl gssadrsqwr eptrtsdglc slyeaalclf eevcrmasdy srtcaspdsi
      361 qtgdapivse tcevyvwgsn sshqlvegtq ekilqpklap sfsdaqtiea gqyctfvist
      421 dgsvracgkg sygrlglgds nnqstlkklt fephrsikkv ssskgsdght lafttegevf
      481 swgdgdygkl ghgnsstqky pkliqgplqg kvvvcvsagy rhsaavtedg elytwgegdf
      541 grlghgdsns rniptlvkdi snvgevscgs shtialskdg rtvwsfgggd ngklghgdtn
      601 rvykpkviea lqgmfirkvc agsqsslalt stgqvyawgc gaclgcgsse atalrpklie
      661 elaatrivdv sigdshclal shdnevyawg nnsmgqcgqg nstgpitkpk kvsgldgiai
      721 qqisagtshs lawtalprdr qvvawhrpyc vdleestfsh lrsflerycd kinseipplp
      781 fpssrehhsf lklclkllsn hlalalaggv atsilgrqag plrnllfrlm dstvpdeiqe
      841 vvietlsvga tmllpplrer mellhsllpq gpdrweslsk gqrmqldiil tslqdhthva
      901 sllgysspsd aadlssvctg ygnlsdqpyg tqschpdthl aeilmktllr nlgfytdqaf
      961 geleknsdkf llgtsssens qpahlhellc slqkqllafc hinnisenss svallhkhlq
     1021 lllphatdiy srsanllkes pwngsvgekl rdviyvsaag smlcqivnsl lllpvsvarp
     1081 llsylldllp pldclnrllp aadlledqel qwplhggpel idpaglplpq paqswvwlvd
     1141 lertiallig rclggmlqgs pvspeeqdta ywmktplfsd gvemdtpqld kcmsclleva
     1201 lsgneeqkpf dyklrpeiav yvdlalgcsk eparslwism qdyavskdwd satlsnesll
     1261 dtvsrfvlaa llkhtnllsq acgesryqpg khlsevyrcv ykvrsrllac knleliqtrs
     1321 ssrdrwisen qdsadvdpqe hsftrtidee aemeeqaerd reeghpeped eeeerehevm
     1381 tagnlvfvlh vteifqcfls arevarsrdr drmnsgagsg araddpppqs qqerrvstdl
     1441 pegqdvytaa cnsvihrcal lilgvspvid elqkrreegq lqqpstsase ggglmtrses
     1501 ltaesrlvht spnyrliksr sesdlsqpes deegyalsgr rnvdldlaas hrkrvylllf
     1561 gqlsprkkks fkqvhdgpmh sqleslsdsw arlkhsrdwl cnssysfesd fdltkslgvh
     1621 tlienvvsfv sgdvgnapgf kepeesmsts pqasiiameq qqlraelrle alhqilvlls
     1681 gmeekgsisl agsrlssgfq sstlltsvrl qflagcfglg tvghtggkge sgrlhhyqdg
     1741 iraakrniqi eiqvavhkiy qqlsatlera lqankhhiea qqrlllvtvf alsvhyqpvd
     1801 vslaistgll nvlsqlcgtd tmlgqplqll pktgvsqlst alkvastrll qilaittgty
     1861 adklspkvvq slldllcsql knllsqtgvl hmasfgegeq edgeeeekkv dssgetekkd
     1921 fraalrkqha aelhlgdflv flrrvvsska iqskmaspkw tevllniasq kcssgiplvg
     1981 nlrtrllalh vleavlpace sgveddqmaq iverlfslls dcmwetpiaq akhaiqikek
     2041 eqeiklqkqg eleeedenlp iqevsfdpek aqcclvengq ilthgsggkg yglastgvts
     2101 gcyqwkfyiv kenrgnegtc vgvsrwpvhd fnhrttsdmw lyraysgnly hngeqtltls
     2161 sftqgdfitc vldmeartis fgkngeepkl afedvdaael ypcvmfyssn pgekvkicdm
     2221 qmrgtprdll pgdpicspva avlaeatiql irilhrtdrw tycinkkmme rlhkikicik
     2281 esgqklkksr svqsreenem reekeskeee kgkhtrhgla dlselqlrtl cievwpvlav
     2341 iggvdaglrv ggrcvhkqtg rhatllgvvk egstsakvqw deaeitisfp tfwspsdtpl
     2401 ynlepceplp fdvarfrglt asvlldltyl tgvhedmgkq stkrhekkhr heseekgdve
     2461 qkpesesald mrtgltsddv ksqsttssks eneiasfsld ptlpsvesqh qitegkrknh
     2521 ehmsknhdva qseiravqls ylylgamksl sallgcskya elllipkvla enghnsdcas
     2581 spvvhedvem raalqflmrh mvkravmrsp ikralgladl eraqamiykl vvhglledqf
     2641 ggkikqeidq qaeesdpaqq aqtpvttsps assttsfmss sledtttatt pvtdtetvpa
     2701 sespgvmpls llrqmfssyp tttvlptrra qtppisslpt spsdevgrrq sltspdsqsa
     2761 rpanrtalsd pssrlstspp ppaiavplle mgfslrqiak ameatgarge adaqnitvla
     2821 mwmiehpghe deeepqsgst adsrpgaavl gsggksndpc ylqspgdips adaaemeegf
     2881 sespdnldht enaasgsgps argrsavtrr hkfdlaartl laraaglyrs vqahrnqsrr
     2941 egislqqdpg alydfnldee leidlddeam eamfgqdlts dndilgmwip evldwptwhv
     3001 cesedreevv vcelcecsvv sfnqhmkrnh pgcgrsanrq gyrsngsyvd gwfggecgsg
     3061 npyyllcgtc rekylamktk skstsseryk gqapdligkq dsvyedwdml dvdedekltg
     3121 eeefellagp lglndrrivp epvqfpdsdp lgasvamvta tnsmeetlmq igchgsveks
     3181 ssgritlgeq aaalanphdr vvalrrvtaa aqvllartmv mralsllsvs gsscslaagl
     3241 eslgltdirt lvrlmclaaa graglstsps amastsersr gghskankpi sclaylstav
     3301 gclasnapsa akllvqlctq nlisaatgvn lttvddsiqr kflpsflrgi aeenklvtsp
     3361 nfvvtqalva lladkgaklr pnydksevek kgliaqlyah psydpsavgp lelanalaac
     3421 clssrlssqh rqwaaqqlvr tlaahdrdnq ttlqtladmg gdlrkcsfik leahqnrvmt
     3481 cvwcnkkgll atsgndgtir vwnvtkkqys lqqtcvfnrl egdaeeslgs psdpsfspvs
     3541 wsisgkylag alekmvniwq vnggkglvdi qphwvsalaw peegpataws gespelllvg
     3601 rmdgslglie vvdvstmhrr elehcyrkdv svtciawfse drpfavgyfd gklllgtkep
     3661 lekggivlid ahkdtlismk wdptghilmt cakedsvklw gsisgcwccl hslchpsivn
     3721 giawcrlpgk gsklqllmat gcqsglvcvw ripqdttqtn vtsaegwweq esncqdgyrk
     3781 ssgakcvyql rghitpvrtv afssdglalv sgglgglmni wslrdgsvlq tvvigsgaiq
     3841 ttvwipevgv aacsnrskdv lvvnctaewa aanhvlatcr talkqqgvlg lnmapcmraf
     3901 lerlpmmlqe qyayekphvv cgdqlvhspy mqclaslavg lhldqllcnp pvpphhqncl
     3961 pdpaswnpne wawlecfstt ikaaealtng aqfpesftvp dlepvpedel vflmdnskwi
     4021 ngmdeqimsw atsrpedwhl ggkcdvylwg agrhgqlaea grnvmvpaaa psfsqaqqvi
     4081 cgqnctfviq angtvlacge gsygrlgqgn sddlhvltvi salqgfvvtq lvtscgsdgh
     4141 smaltesgev fswgdgdygk lghgnsdrqr rprqiealqg eevvqmscgf khsavvtsdg
     4201 klftfgngdy grlglgntsn kklpervtal egyqigqvac glnhtlavsa dgsmvwafgd
     4261 gdygklglgn staksspqki dvlcgigikk vacgtqfsva ltkdghvytf gqdrliglpe
     4321 grarnhnrpq qipvlagvii edvavgaeht lalasngdvy awgsnsegql glghtnhvre
     4381 ptlvtglqgk nvrqisagrc hsaawtappv pprapgvsvp lqlglpdtvp pqygalrevs
     4441 ihtvrarlrl lyhfsdlmys swrllnlspn nqnstshyna gtwgivqgql rpllaprvyt
     4501 lpmvrsigkt mvqgknygpq itvkristrg rkckpifvqi arqvvklnas dlrlpsrawk
     4561 vklvgegadd aggvfddtit emcqeletgi vdllipspna taevgynrdr flfnpsacld
     4621 ehlmqfkflg ilmgvairtk kpldlhlapl vwkqlccvpl tledleevdl lyvqtlnsil
     4681 hiedsgitee sfhemiplds fvgqsadgkm vpiipggnsi pltfsnrkey veraieyrlh
     4741 emdrqvaavr egmswivpvp llslltakql eqmvcgmpei svevlkkvvr yrevdeqhql
     4801 vqwfwhtlee fsneervlfm rfvsgrsrlp antadisqrf qimkvdrpyd slptsqtcff
     4861 qlrlppyssq lvmaerlrya inncrsidmd nymlsrnvdn aegsdtdy
//
LOCUS       XP_047289169            4902 aa            linear   PRI 05-AUG-2025
DEFINITION  putative E3 ubiquitin-protein ligase HERC1 isoform X3 [Homo
            sapiens].
ACCESSION   XP_047289169
VERSION     XP_047289169.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433213.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4902
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4902
                     /product="putative E3 ubiquitin-protein ligase HERC1
                     isoform X3"
                     /calculated_mol_wt=536624
     Region          374..703
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          683..733
                     /region_name="RCC1"
                     /note="Regulator of chromosome condensation (RCC1) repeat;
                     pfam00415"
                     /db_xref="CDD:395335"
     Region          2063..2220
                     /region_name="SPRY_HERC1"
                     /note="SPRY domain in HERC1; cd12881"
                     /db_xref="CDD:293939"
     Region          2784..2827
                     /region_name="UBA_HERC1"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC1 and similar proteins; cd14401"
                     /db_xref="CDD:270584"
     Region          <3428..3819
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          3473..3516
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3530..3565
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3570..3617
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3626..3661
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3670..3706
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3713..3744
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3791..3827
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          4040..4376
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          4514..4882
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4519,4560,4571,4638,4816,4846..4847,4850..4854,4874,
                     4881)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4666,4669..4670,4672..4673,4676,4684,4686,
                     4690..4691,4693,4702,4707,4724,4728)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4902
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /coded_by="XM_047433213.1:154..14862"
                     /db_xref="GeneID:8925"
                     /db_xref="HGNC:HGNC:4867"
                     /db_xref="MIM:605109"
ORIGIN      
        1 matmippvkl kwlehlnssw itedsesiat regvavlysk lvsnkevvpl pqqvlclkgp
       61 qlpdferesl ssdeqdhyld allssqlala kmvcsdspfa galrkrllvl qrvfyalsnk
      121 yhdkgkvkqq qhspesssgs advhsvserp rsstdaliem gvrtglsllf allrqswmmp
      181 vsgpglslcn dvihtaievv sslpplslan eskippmgld clsqvttflk gvtipnsgad
      241 tlgrrlasel llglaaqrgs lryllewiem algasavvht mekgkllssq egmisfdcfm
      301 tilmqmrrsl gssadrsqwr eptrtsdglc slyeaalclf eevcrmasdy srtcaspdsi
      361 qtgdapivse tcevyvwgsn sshqlvegtq ekilqpklap sfsdaqtiea gqyctfvist
      421 dgsvracgkg sygrlglgds nnqstlkklt fephrsikkv ssskgsdght lafttegevf
      481 swgdgdygkl ghgnsstqky pkliqgplqg kvvvcvsagy rhsaavtedg elytwgegdf
      541 grlghgdsns rniptlvkdi snvgevscgs shtialskdg rtvwsfgggd ngklghgdtn
      601 rvykpkviea lqgmfirkvc agsqsslalt stgqvyawgc gaclgcgsse atalrpklie
      661 elaatrivdv sigdshclal shdnevyawg nnsmgqcgqg nstgpitkpk kvsgldgiai
      721 qqisagtshs lawtalprdr qvvawhrpyc vdleestfsh lrsflerycd kinseipplp
      781 fpssrehhsf lklclkllsn hlalalaggv atsilgrqag plrnllfrlm dstvpdeiqe
      841 vvietlsvga tmllpplrer mellhsllpq gpdrweslsk gqrmqldiil tslqdhthva
      901 sllgysspsd aadlssvctg ygnlsdqpyg tqschpdthl aeilmktllr nlgfytdqaf
      961 geleknsdkf llgtsssens qpahlhellc slqkqllafc hinnisenss svallhkhlq
     1021 lllphatdiy srsanllkes pwngsvgekl rdviyvsaag smlcqivnsl lllpvsvarp
     1081 llsylldllp pldclnrllp aadlledqel qwplhggpel idpaglplpq paqswvwlvd
     1141 lertiallig rclggmlqgs pvspeeqdta ywmktplfsd gvemdtpqld kcmsclleva
     1201 lsgneeqkpf dyklrpeiav yvdlalgcsk eparslwism qdyavskdwd satlsnesll
     1261 dtvsrfvlaa llkhtnllsq acgesryqpg khlsevyrcv ykvrsrllac knleliqtrs
     1321 ssrdrwisen qdsadvdpqe hsftrtidee aemeeqaerd reeghpeped eeeerehevm
     1381 tagnlvfvlh vteifqcfls arevarsrdr drmnsgagsg araddpppqs qqerrvstdl
     1441 pegqdvytaa cnsvihrcal lilgvspvid elqkrreegq lqqpstsase ggglmtrses
     1501 ltaesrlvht spnyrliksr sesdlsqpes deegyalsgr rnvdldlaas hrkrvylllf
     1561 gqlsprkkks fkqvhdgpmh sqleslsdsw arlkhsrdwl cnssysfesd fdltkslgvh
     1621 tlienvvsfv sgdvgnapgf kepeesmsts pqasiiameq qqlraelrle alhqilvlls
     1681 gmeekgsisl agsrlssgfq sstlltsvrl qflagcfglg tvghtggkge sgrlhhyqdg
     1741 iraakrniqi eiqvavhkiy qqlsatlera lqankhhiea qqrlllvtvf alsvhyqpvd
     1801 vslaistgll nvlsqlcgtd tmlgqplqll pktgvsqlst alkvastrll qilaittgty
     1861 adklspkvvq slldllcsql knllsqtgvl hmasfgegeq edgeeeekkv dssgetekkd
     1921 fraalrkqha aelhlgdflv flrrvvsska iqskmaspkw tevllniasq kcssgiplvg
     1981 nlrtrllalh vleavlpace sgveddqmaq iverlfslls dcmwetpiaq akhaiqikek
     2041 eqeiklqkqg eleeedenlp iqevsfdpek aqcclvengq ilthgsggkg yglastgvts
     2101 gcyqwkfyiv kenrgnegtc vgvsrwpvhd fnhrttsdmw lyraysgnly hngeqtltls
     2161 sftqgdfitc vldmeartis fgkngeepkl afedvdaael ypcvmfyssn pgekvkicdm
     2221 qmrgtprdll pgdpicspva avlaeatiql irilhrtdrw tycinkkmme rlhkikicik
     2281 esgqklkksr svqsreenem reekeskeee kgkhtrhgla dlselqlrtl cievwpvlav
     2341 iggvdaglrv ggrcvhkqtg rhatllgvvk egstsakvqw deaeitisfp tfwspsdtpl
     2401 ynlepceplp fdvarfrglt asvlldltyl tgvhedmgkq stkrhekkhr heseekgdve
     2461 qkpesesald mrtgltsddv ksqsttssks eneiasfsld ptlpsvesqh qitegkrknh
     2521 ehmsknhdva qseiravqls ylylgamksl sallgcskya elllipkvla enghnsdcas
     2581 spvvhedvem raalqflmrh mvkravmrsp ikralgladl eraqamiykl vvhglledqf
     2641 ggkikqeidq qaeesdpaqq aqtpvttsps assttsfmss sledtttatt pvtdtetvpa
     2701 sespgvmpls llrqmfssyp tttvlptrra qtppisslpt spsdevgrrq sltspdsqsa
     2761 rpanrtalsd pssrlstspp ppaiavplle mgfslrqiak ameatgarge adaqnitvla
     2821 mwmiehpghe deeepqsgst adsrpgaavl gsggksndpc ylqspgdips adaaemeegf
     2881 sespdnldht enaasgsgps argrsavtrr hkfdlaartl laraaglyrs vqahrnqsrr
     2941 egislqqdpg alydfnldee leidlddeam eamfgqdlts dndilgmwip ehvcesedre
     3001 evvvcelcec svvsfnqhmk rnhpgcgrsa nrqgyrsngs yvdgwfggec gsgnpyyllc
     3061 gtcrekylam ktkskstsse rykgqapdli gkqdsvyeed wdmldvdede kltgeeefel
     3121 lagplglndr rivpepvqfp dsdplgasva mvtatnsmee tlmqigchgs veksssgrit
     3181 lgeqaaalan phdrvvalrr vtaaaqvlla rtmvmralsl lsvsgsscsl aagleslglt
     3241 dirtlvrlmc laaagragls tspsamasts ersrgghska nkpisclayl stavgclasn
     3301 apsaakllvq lctqnlisaa tgvnlttvdd siqrkflpsf lrgiaeenkl vtspnfvvtq
     3361 alvalladkg aklrpnydks evekkgliaq lyahpsydps avgplelana laacclssrl
     3421 ssqhrqwaaq qlvrtlaahd rdnqttlqtl admggdlrkc sfikleahqn rvmtcvwcnk
     3481 kgllatsgnd gtirvwnvtk kqyslqqtcv fnrlegdaee slgspsdpsf spvswsisgk
     3541 ylagalekmv niwqvnggkg lvdiqphwvs alawpeegpa tawsgespel llvgrmdgsl
     3601 glievvdvst mhrrelehcy rkdvsvtcia wfsedrpfav gyfdgklllg tkeplekggi
     3661 vlidahkdtl ismkwdptgh ilmtcakeds vklwgsisgc wcclhslchp sivngiawcr
     3721 lpgkgsklql lmatgcqsgl vcvwripqdt tqtnvtsaeg wweqesncqd gyrkssgakc
     3781 vyqlrghitp vrtvafssdg lalvsgglgg lmniwslrdg svlqtvvigs gaiqttvwip
     3841 evgvaacsnr skdvlvvnct aewaaanhvl atcrtalkqq gvlglnmapc mraflerlpm
     3901 mlqeqyayek phvvcgdqlv hspymqclas lavglhldql lcnppvpphh qnclpdpasw
     3961 npnewawlec fsttikaaea ltngaqfpes ftvpdlepvp edelvflmdn skwingmdeq
     4021 imswatsrpe dwhlggkcdv ylwgagrhgq laeagrnvmv paaapsfsqa qqvicgqnct
     4081 fviqangtvl acgegsygrl gqgnsddlhv ltvisalqgf vvtqlvtscg sdghsmalte
     4141 sgevfswgdg dygklghgns drqrrprqie alqgeevvqm scgfkhsavv tsdgklftfg
     4201 ngdygrlglg ntsnkklper vtalegyqig qvacglnhtl avsadgsmvw afgdgdygkl
     4261 glgnstakss pqkidvlcgi gikkvacgtq fsvaltkdgh vytfgqdrli glpegrarnh
     4321 nrpqqipvla gviiedvavg aehtlalasn gdvyawgsns egqlglghtn hvreptlvtg
     4381 lqgknvrqis agrchsaawt appvpprapg vsvplqlglp dtvppqygal revsihtvra
     4441 rlrllyhfsd lmysswrlln lspnnqnsts hynagtwgiv qgqlrpllap rvytlpmvrs
     4501 igktmvqgkn ygpqitvkri strgrkckpi fvqiarqvvk lnasdlrlps rawkvklvge
     4561 gaddaggvfd dtitemcqel etgivdllip spnataevgy nrdrflfnps acldehlmqf
     4621 kflgilmgva irtkkpldlh laplvwkqlc cvpltledle evdllyvqtl nsilhiedsg
     4681 iteesfhemi pldsfvgqsa dgkmvpiipg gnsipltfsn rkeyveraie yrlhemdrqv
     4741 aavregmswi vpvpllsllt akqleqmvcg mpeisvevlk kvvryrevde qhqlvqwfwh
     4801 tleefsneer vlfmrfvsgr srlpantadi sqrfqimkvd rpydslptsq tcffqlrlpp
     4861 yssqlvmaer lryainncrs idmdnymlsr nvdnaegsdt dy
//
LOCUS       XP_047289170            4901 aa            linear   PRI 05-AUG-2025
DEFINITION  putative E3 ubiquitin-protein ligase HERC1 isoform X4 [Homo
            sapiens].
ACCESSION   XP_047289170
VERSION     XP_047289170.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433214.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4901
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4901
                     /product="putative E3 ubiquitin-protein ligase HERC1
                     isoform X4"
                     /calculated_mol_wt=536572
     Region          374..703
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          683..733
                     /region_name="RCC1"
                     /note="Regulator of chromosome condensation (RCC1) repeat;
                     pfam00415"
                     /db_xref="CDD:395335"
     Region          2063..2220
                     /region_name="SPRY_HERC1"
                     /note="SPRY domain in HERC1; cd12881"
                     /db_xref="CDD:293939"
     Region          2776..2819
                     /region_name="UBA_HERC1"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC1 and similar proteins; cd14401"
                     /db_xref="CDD:270584"
     Region          <3427..3818
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          3472..3515
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3529..3564
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3569..3616
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3625..3660
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3669..3705
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3712..3743
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3790..3826
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          4039..4375
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          4513..4881
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4518,4559,4570,4637,4815,4845..4846,4849..4853,4873,
                     4880)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4665,4668..4669,4671..4672,4675,4683,4685,
                     4689..4690,4692,4701,4706,4723,4727)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4901
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /coded_by="XM_047433214.1:154..14859"
                     /db_xref="GeneID:8925"
                     /db_xref="HGNC:HGNC:4867"
                     /db_xref="MIM:605109"
ORIGIN      
        1 matmippvkl kwlehlnssw itedsesiat regvavlysk lvsnkevvpl pqqvlclkgp
       61 qlpdferesl ssdeqdhyld allssqlala kmvcsdspfa galrkrllvl qrvfyalsnk
      121 yhdkgkvkqq qhspesssgs advhsvserp rsstdaliem gvrtglsllf allrqswmmp
      181 vsgpglslcn dvihtaievv sslpplslan eskippmgld clsqvttflk gvtipnsgad
      241 tlgrrlasel llglaaqrgs lryllewiem algasavvht mekgkllssq egmisfdcfm
      301 tilmqmrrsl gssadrsqwr eptrtsdglc slyeaalclf eevcrmasdy srtcaspdsi
      361 qtgdapivse tcevyvwgsn sshqlvegtq ekilqpklap sfsdaqtiea gqyctfvist
      421 dgsvracgkg sygrlglgds nnqstlkklt fephrsikkv ssskgsdght lafttegevf
      481 swgdgdygkl ghgnsstqky pkliqgplqg kvvvcvsagy rhsaavtedg elytwgegdf
      541 grlghgdsns rniptlvkdi snvgevscgs shtialskdg rtvwsfgggd ngklghgdtn
      601 rvykpkviea lqgmfirkvc agsqsslalt stgqvyawgc gaclgcgsse atalrpklie
      661 elaatrivdv sigdshclal shdnevyawg nnsmgqcgqg nstgpitkpk kvsgldgiai
      721 qqisagtshs lawtalprdr qvvawhrpyc vdleestfsh lrsflerycd kinseipplp
      781 fpssrehhsf lklclkllsn hlalalaggv atsilgrqag plrnllfrlm dstvpdeiqe
      841 vvietlsvga tmllpplrer mellhsllpq gpdrweslsk gqrmqldiil tslqdhthva
      901 sllgysspsd aadlssvctg ygnlsdqpyg tqschpdthl aeilmktllr nlgfytdqaf
      961 geleknsdkf llgtsssens qpahlhellc slqkqllafc hinnisenss svallhkhlq
     1021 lllphatdiy srsanllkes pwngsvgekl rdviyvsaag smlcqivnsl lllpvsvarp
     1081 llsylldllp pldclnrllp aadlledqel qwplhggpel idpaglplpq paqswvwlvd
     1141 lertiallig rclggmlqgs pvspeeqdta ywmktplfsd gvemdtpqld kcmsclleva
     1201 lsgneeqkpf dyklrpeiav yvdlalgcsk eparslwism qdyavskdwd satlsnesll
     1261 dtvsrfvlaa llkhtnllsq acgesryqpg khlsevyrcv ykvrsrllac knleliqtrs
     1321 ssrdrwisen qdsadvdpqe hsftrtidee aemeeqaerd reeghpeped eeeerehevm
     1381 tagnlvfvlh vteifqcfls arevarsrdr drmnsgagsg araddpppqs qqerrvstdl
     1441 pegqdvytaa cnsvihrcal lilgvspvid elqkrreegq lqqpstsase ggglmtrses
     1501 ltaesrlvht spnyrliksr sesdlsqpes deegyalsgr rnvdldlaas hrkrvylllf
     1561 gqlsprkkks fkqvhdgpmh sqleslsdsw arlkhsrdwl cnssysfesd fdltkslgvh
     1621 tlienvvsfv sgdvgnapgf kepeesmsts pqasiiameq qqlraelrle alhqilvlls
     1681 gmeekgsisl agsrlssgfq sstlltsvrl qflagcfglg tvghtggkge sgrlhhyqdg
     1741 iraakrniqi eiqvavhkiy qqlsatlera lqankhhiea qqrlllvtvf alsvhyqpvd
     1801 vslaistgll nvlsqlcgtd tmlgqplqll pktgvsqlst alkvastrll qilaittgty
     1861 adklspkvvq slldllcsql knllsqtgvl hmasfgegeq edgeeeekkv dssgetekkd
     1921 fraalrkqha aelhlgdflv flrrvvsska iqskmaspkw tevllniasq kcssgiplvg
     1981 nlrtrllalh vleavlpace sgveddqmaq iverlfslls dcmwetpiaq akhaiqikek
     2041 eqeiklqkqg eleeedenlp iqevsfdpek aqcclvengq ilthgsggkg yglastgvts
     2101 gcyqwkfyiv kenrgnegtc vgvsrwpvhd fnhrttsdmw lyraysgnly hngeqtltls
     2161 sftqgdfitc vldmeartis fgkngeepkl afedvdaael ypcvmfyssn pgekvkicdm
     2221 qmrgtprdll pgdpicspva avlaeatiql irilhrtdrw tycinkkmme rlhkikicik
     2281 esgqklkksr svqsreenem reekeskeee kgkhtrhgla dlselqlrtl cievwpvlav
     2341 iggvdaglrv ggrcvhkqtg rhatllgvvk egstsakvqw deaeitisdt plynlepcep
     2401 lpfdvarfrg ltasvlldlt yltgvhedmg kqstkrhekk hrheseekgd veqkpesesa
     2461 ldmrtgltsd dvksqsttss kseneiasfs ldptlpsves qhqitegkrk nhehmsknhd
     2521 vaqseiravq lsylylgamk slsallgcsk yaelllipkv laenghnsdc asspvvhedv
     2581 emraalqflm rhmvkravmr spikralgla dleraqamiy klvvhglled qfggkikqei
     2641 dqqaeesdpa qqaqtpvtts psassttsfm sssledttta ttpvtdtetv pasespgvmp
     2701 lsllrqmfss yptttvlptr raqtppissl ptspsdevgr rqsltspdsq sarpanrtal
     2761 sdpssrlsts ppppaiavpl lemgfslrqi akameatgar geadaqnitv lamwmiehpg
     2821 hedeeepqsg stadsrpgaa vlgsggksnd pcylqspgdi psadaaemee gfsespdnld
     2881 htenaasgsg psargrsavt rrhkfdlaar tllaraagly rsvqahrnqs rregislqqd
     2941 pgalydfnld eeleidldde ameamfgqdl tsdndilgmw ipevldwptw hvcesedree
     3001 vvvcelcecs vvsfnqhmkr nhpgcgrsan rqgyrsngsy vdgwfggecg sgnpyyllcg
     3061 tcrekylamk tkskstsser ykgqapdlig kqdsvyeedw dmldvdedek ltgeeefell
     3121 agplglndrr ivpepvqfpd sdplgasvam vtatnsmeet lmqigchgsv eksssgritl
     3181 geqaaalanp hdrvvalrrv taaaqvllar tmvmralsll svsgsscsla agleslgltd
     3241 irtlvrlmcl aaagraglst spsamastse rsrgghskan kpisclayls tavgclasna
     3301 psaakllvql ctqnlisaat gvnlttvdds iqrkflpsfl rgiaeenklv tspnfvvtqa
     3361 lvalladkga klrpnydkse vekkgliaql yahpsydpsa vgplelanal aacclssrls
     3421 sqhrqwaaqq lvrtlaahdr dnqttlqtla dmggdlrkcs fikleahqnr vmtcvwcnkk
     3481 gllatsgndg tirvwnvtkk qyslqqtcvf nrlegdaees lgspsdpsfs pvswsisgky
     3541 lagalekmvn iwqvnggkgl vdiqphwvsa lawpeegpat awsgespell lvgrmdgslg
     3601 lievvdvstm hrrelehcyr kdvsvtciaw fsedrpfavg yfdgklllgt keplekggiv
     3661 lidahkdtli smkwdptghi lmtcakedsv klwgsisgcw cclhslchps ivngiawcrl
     3721 pgkgsklqll matgcqsglv cvwripqdtt qtnvtsaegw weqesncqdg yrkssgakcv
     3781 yqlrghitpv rtvafssdgl alvsgglggl mniwslrdgs vlqtvvigsg aiqttvwipe
     3841 vgvaacsnrs kdvlvvncta ewaaanhvla tcrtalkqqg vlglnmapcm raflerlpmm
     3901 lqeqyayekp hvvcgdqlvh spymqclasl avglhldqll cnppvpphhq nclpdpaswn
     3961 pnewawlecf sttikaaeal tngaqfpesf tvpdlepvpe delvflmdns kwingmdeqi
     4021 mswatsrped whlggkcdvy lwgagrhgql aeagrnvmvp aaapsfsqaq qvicgqnctf
     4081 viqangtvla cgegsygrlg qgnsddlhvl tvisalqgfv vtqlvtscgs dghsmaltes
     4141 gevfswgdgd ygklghgnsd rqrrprqiea lqgeevvqms cgfkhsavvt sdgklftfgn
     4201 gdygrlglgn tsnkklperv talegyqigq vacglnhtla vsadgsmvwa fgdgdygklg
     4261 lgnstakssp qkidvlcgig ikkvacgtqf svaltkdghv ytfgqdrlig lpegrarnhn
     4321 rpqqipvlag viiedvavga ehtlalasng dvyawgsnse gqlglghtnh vreptlvtgl
     4381 qgknvrqisa grchsaawta ppvpprapgv svplqlglpd tvppqygalr evsihtvrar
     4441 lrllyhfsdl mysswrllnl spnnqnstsh ynagtwgivq gqlrpllapr vytlpmvrsi
     4501 gktmvqgkny gpqitvkris trgrkckpif vqiarqvvkl nasdlrlpsr awkvklvgeg
     4561 addaggvfdd titemcqele tgivdllips pnataevgyn rdrflfnpsa cldehlmqfk
     4621 flgilmgvai rtkkpldlhl aplvwkqlcc vpltledlee vdllyvqtln silhiedsgi
     4681 teesfhemip ldsfvgqsad gkmvpiipgg nsipltfsnr keyveraiey rlhemdrqva
     4741 avregmswiv pvpllsllta kqleqmvcgm peisvevlkk vvryrevdeq hqlvqwfwht
     4801 leefsneerv lfmrfvsgrs rlpantadis qrfqimkvdr pydslptsqt cffqlrlppy
     4861 ssqlvmaerl ryainncrsi dmdnymlsrn vdnaegsdtd y
//
LOCUS       XP_047289171            4901 aa            linear   PRI 05-AUG-2025
DEFINITION  putative E3 ubiquitin-protein ligase HERC1 isoform X5 [Homo
            sapiens].
ACCESSION   XP_047289171
VERSION     XP_047289171.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433215.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4901
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4901
                     /product="putative E3 ubiquitin-protein ligase HERC1
                     isoform X5"
                     /calculated_mol_wt=536495
     Region          374..703
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          683..733
                     /region_name="RCC1"
                     /note="Regulator of chromosome condensation (RCC1) repeat;
                     pfam00415"
                     /db_xref="CDD:395335"
     Region          2063..2220
                     /region_name="SPRY_HERC1"
                     /note="SPRY domain in HERC1; cd12881"
                     /db_xref="CDD:293939"
     Region          2784..2827
                     /region_name="UBA_HERC1"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC1 and similar proteins; cd14401"
                     /db_xref="CDD:270584"
     Region          <3427..3818
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          3472..3515
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3529..3564
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3569..3616
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3625..3660
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3669..3705
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3712..3743
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3790..3826
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          4039..4375
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          4513..4881
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4518,4559,4570,4637,4815,4845..4846,4849..4853,4873,
                     4880)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4665,4668..4669,4671..4672,4675,4683,4685,
                     4689..4690,4692,4701,4706,4723,4727)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4901
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /coded_by="XM_047433215.1:154..14859"
                     /db_xref="GeneID:8925"
                     /db_xref="HGNC:HGNC:4867"
                     /db_xref="MIM:605109"
ORIGIN      
        1 matmippvkl kwlehlnssw itedsesiat regvavlysk lvsnkevvpl pqqvlclkgp
       61 qlpdferesl ssdeqdhyld allssqlala kmvcsdspfa galrkrllvl qrvfyalsnk
      121 yhdkgkvkqq qhspesssgs advhsvserp rsstdaliem gvrtglsllf allrqswmmp
      181 vsgpglslcn dvihtaievv sslpplslan eskippmgld clsqvttflk gvtipnsgad
      241 tlgrrlasel llglaaqrgs lryllewiem algasavvht mekgkllssq egmisfdcfm
      301 tilmqmrrsl gssadrsqwr eptrtsdglc slyeaalclf eevcrmasdy srtcaspdsi
      361 qtgdapivse tcevyvwgsn sshqlvegtq ekilqpklap sfsdaqtiea gqyctfvist
      421 dgsvracgkg sygrlglgds nnqstlkklt fephrsikkv ssskgsdght lafttegevf
      481 swgdgdygkl ghgnsstqky pkliqgplqg kvvvcvsagy rhsaavtedg elytwgegdf
      541 grlghgdsns rniptlvkdi snvgevscgs shtialskdg rtvwsfgggd ngklghgdtn
      601 rvykpkviea lqgmfirkvc agsqsslalt stgqvyawgc gaclgcgsse atalrpklie
      661 elaatrivdv sigdshclal shdnevyawg nnsmgqcgqg nstgpitkpk kvsgldgiai
      721 qqisagtshs lawtalprdr qvvawhrpyc vdleestfsh lrsflerycd kinseipplp
      781 fpssrehhsf lklclkllsn hlalalaggv atsilgrqag plrnllfrlm dstvpdeiqe
      841 vvietlsvga tmllpplrer mellhsllpq gpdrweslsk gqrmqldiil tslqdhthva
      901 sllgysspsd aadlssvctg ygnlsdqpyg tqschpdthl aeilmktllr nlgfytdqaf
      961 geleknsdkf llgtsssens qpahlhellc slqkqllafc hinnisenss svallhkhlq
     1021 lllphatdiy srsanllkes pwngsvgekl rdviyvsaag smlcqivnsl lllpvsvarp
     1081 llsylldllp pldclnrllp aadlledqel qwplhggpel idpaglplpq paqswvwlvd
     1141 lertiallig rclggmlqgs pvspeeqdta ywmktplfsd gvemdtpqld kcmsclleva
     1201 lsgneeqkpf dyklrpeiav yvdlalgcsk eparslwism qdyavskdwd satlsnesll
     1261 dtvsrfvlaa llkhtnllsq acgesryqpg khlsevyrcv ykvrsrllac knleliqtrs
     1321 ssrdrwisen qdsadvdpqe hsftrtidee aemeeqaerd reeghpeped eeeerehevm
     1381 tagnlvfvlh vteifqcfls arevarsrdr drmnsgagsg araddpppqs qqerrvstdl
     1441 pegqdvytaa cnsvihrcal lilgvspvid elqkrreegq lqqpstsase ggglmtrses
     1501 ltaesrlvht spnyrliksr sesdlsqpes deegyalsgr rnvdldlaas hrkrvylllf
     1561 gqlsprkkks fkqvhdgpmh sqleslsdsw arlkhsrdwl cnssysfesd fdltkslgvh
     1621 tlienvvsfv sgdvgnapgf kepeesmsts pqasiiameq qqlraelrle alhqilvlls
     1681 gmeekgsisl agsrlssgfq sstlltsvrl qflagcfglg tvghtggkge sgrlhhyqdg
     1741 iraakrniqi eiqvavhkiy qqlsatlera lqankhhiea qqrlllvtvf alsvhyqpvd
     1801 vslaistgll nvlsqlcgtd tmlgqplqll pktgvsqlst alkvastrll qilaittgty
     1861 adklspkvvq slldllcsql knllsqtgvl hmasfgegeq edgeeeekkv dssgetekkd
     1921 fraalrkqha aelhlgdflv flrrvvsska iqskmaspkw tevllniasq kcssgiplvg
     1981 nlrtrllalh vleavlpace sgveddqmaq iverlfslls dcmwetpiaq akhaiqikek
     2041 eqeiklqkqg eleeedenlp iqevsfdpek aqcclvengq ilthgsggkg yglastgvts
     2101 gcyqwkfyiv kenrgnegtc vgvsrwpvhd fnhrttsdmw lyraysgnly hngeqtltls
     2161 sftqgdfitc vldmeartis fgkngeepkl afedvdaael ypcvmfyssn pgekvkicdm
     2221 qmrgtprdll pgdpicspva avlaeatiql irilhrtdrw tycinkkmme rlhkikicik
     2281 esgqklkksr svqsreenem reekeskeee kgkhtrhgla dlselqlrtl cievwpvlav
     2341 iggvdaglrv ggrcvhkqtg rhatllgvvk egstsakvqw deaeitisfp tfwspsdtpl
     2401 ynlepceplp fdvarfrglt asvlldltyl tgvhedmgkq stkrhekkhr heseekgdve
     2461 qkpesesald mrtgltsddv ksqsttssks eneiasfsld ptlpsvesqh qitegkrknh
     2521 ehmsknhdva qseiravqls ylylgamksl sallgcskya elllipkvla enghnsdcas
     2581 spvvhedvem raalqflmrh mvkravmrsp ikralgladl eraqamiykl vvhglledqf
     2641 ggkikqeidq qaeesdpaqq aqtpvttsps assttsfmss sledtttatt pvtdtetvpa
     2701 sespgvmpls llrqmfssyp tttvlptrra qtppisslpt spsdevgrrq sltspdsqsa
     2761 rpanrtalsd pssrlstspp ppaiavplle mgfslrqiak ameatgarge adaqnitvla
     2821 mwmiehpghe deeepqsgst adsrpgaavl gsggksndpc ylqspgdips adaaemeegf
     2881 sespdnldht enaasgsgps argrsavtrr hkfdlaartl laraaglyrs vqahrnqsrr
     2941 egislqqdpg alydfnldee leidlddeam eamfgqdlts dndilgmwip ehvcesedre
     3001 evvvcelcec svvsfnqhmk rnhpgcgrsa nrqgyrsngs yvdgwfggec gsgnpyyllc
     3061 gtcrekylam ktkskstsse rykgqapdli gkqdsvyedw dmldvdedek ltgeeefell
     3121 agplglndrr ivpepvqfpd sdplgasvam vtatnsmeet lmqigchgsv eksssgritl
     3181 geqaaalanp hdrvvalrrv taaaqvllar tmvmralsll svsgsscsla agleslgltd
     3241 irtlvrlmcl aaagraglst spsamastse rsrgghskan kpisclayls tavgclasna
     3301 psaakllvql ctqnlisaat gvnlttvdds iqrkflpsfl rgiaeenklv tspnfvvtqa
     3361 lvalladkga klrpnydkse vekkgliaql yahpsydpsa vgplelanal aacclssrls
     3421 sqhrqwaaqq lvrtlaahdr dnqttlqtla dmggdlrkcs fikleahqnr vmtcvwcnkk
     3481 gllatsgndg tirvwnvtkk qyslqqtcvf nrlegdaees lgspsdpsfs pvswsisgky
     3541 lagalekmvn iwqvnggkgl vdiqphwvsa lawpeegpat awsgespell lvgrmdgslg
     3601 lievvdvstm hrrelehcyr kdvsvtciaw fsedrpfavg yfdgklllgt keplekggiv
     3661 lidahkdtli smkwdptghi lmtcakedsv klwgsisgcw cclhslchps ivngiawcrl
     3721 pgkgsklqll matgcqsglv cvwripqdtt qtnvtsaegw weqesncqdg yrkssgakcv
     3781 yqlrghitpv rtvafssdgl alvsgglggl mniwslrdgs vlqtvvigsg aiqttvwipe
     3841 vgvaacsnrs kdvlvvncta ewaaanhvla tcrtalkqqg vlglnmapcm raflerlpmm
     3901 lqeqyayekp hvvcgdqlvh spymqclasl avglhldqll cnppvpphhq nclpdpaswn
     3961 pnewawlecf sttikaaeal tngaqfpesf tvpdlepvpe delvflmdns kwingmdeqi
     4021 mswatsrped whlggkcdvy lwgagrhgql aeagrnvmvp aaapsfsqaq qvicgqnctf
     4081 viqangtvla cgegsygrlg qgnsddlhvl tvisalqgfv vtqlvtscgs dghsmaltes
     4141 gevfswgdgd ygklghgnsd rqrrprqiea lqgeevvqms cgfkhsavvt sdgklftfgn
     4201 gdygrlglgn tsnkklperv talegyqigq vacglnhtla vsadgsmvwa fgdgdygklg
     4261 lgnstakssp qkidvlcgig ikkvacgtqf svaltkdghv ytfgqdrlig lpegrarnhn
     4321 rpqqipvlag viiedvavga ehtlalasng dvyawgsnse gqlglghtnh vreptlvtgl
     4381 qgknvrqisa grchsaawta ppvpprapgv svplqlglpd tvppqygalr evsihtvrar
     4441 lrllyhfsdl mysswrllnl spnnqnstsh ynagtwgivq gqlrpllapr vytlpmvrsi
     4501 gktmvqgkny gpqitvkris trgrkckpif vqiarqvvkl nasdlrlpsr awkvklvgeg
     4561 addaggvfdd titemcqele tgivdllips pnataevgyn rdrflfnpsa cldehlmqfk
     4621 flgilmgvai rtkkpldlhl aplvwkqlcc vpltledlee vdllyvqtln silhiedsgi
     4681 teesfhemip ldsfvgqsad gkmvpiipgg nsipltfsnr keyveraiey rlhemdrqva
     4741 avregmswiv pvpllsllta kqleqmvcgm peisvevlkk vvryrevdeq hqlvqwfwht
     4801 leefsneerv lfmrfvsgrs rlpantadis qrfqimkvdr pydslptsqt cffqlrlppy
     4861 ssqlvmaerl ryainncrsi dmdnymlsrn vdnaegsdtd y
//
LOCUS       XP_047289172            4894 aa            linear   PRI 05-AUG-2025
DEFINITION  putative E3 ubiquitin-protein ligase HERC1 isoform X6 [Homo
            sapiens].
ACCESSION   XP_047289172
VERSION     XP_047289172.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433216.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4894
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4894
                     /product="putative E3 ubiquitin-protein ligase HERC1
                     isoform X6"
                     /calculated_mol_wt=535674
     Region          374..703
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          683..733
                     /region_name="RCC1"
                     /note="Regulator of chromosome condensation (RCC1) repeat;
                     pfam00415"
                     /db_xref="CDD:395335"
     Region          2063..2220
                     /region_name="SPRY_HERC1"
                     /note="SPRY domain in HERC1; cd12881"
                     /db_xref="CDD:293939"
     Region          2776..2819
                     /region_name="UBA_HERC1"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC1 and similar proteins; cd14401"
                     /db_xref="CDD:270584"
     Region          <3420..3811
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          3465..3508
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3522..3557
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3562..3609
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3618..3653
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3662..3698
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3705..3736
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3783..3819
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          4032..4368
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          4506..4874
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4511,4552,4563,4630,4808,4838..4839,4842..4846,4866,
                     4873)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4658,4661..4662,4664..4665,4668,4676,4678,
                     4682..4683,4685,4694,4699,4716,4720)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4894
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /coded_by="XM_047433216.1:154..14838"
                     /db_xref="GeneID:8925"
                     /db_xref="HGNC:HGNC:4867"
                     /db_xref="MIM:605109"
ORIGIN      
        1 matmippvkl kwlehlnssw itedsesiat regvavlysk lvsnkevvpl pqqvlclkgp
       61 qlpdferesl ssdeqdhyld allssqlala kmvcsdspfa galrkrllvl qrvfyalsnk
      121 yhdkgkvkqq qhspesssgs advhsvserp rsstdaliem gvrtglsllf allrqswmmp
      181 vsgpglslcn dvihtaievv sslpplslan eskippmgld clsqvttflk gvtipnsgad
      241 tlgrrlasel llglaaqrgs lryllewiem algasavvht mekgkllssq egmisfdcfm
      301 tilmqmrrsl gssadrsqwr eptrtsdglc slyeaalclf eevcrmasdy srtcaspdsi
      361 qtgdapivse tcevyvwgsn sshqlvegtq ekilqpklap sfsdaqtiea gqyctfvist
      421 dgsvracgkg sygrlglgds nnqstlkklt fephrsikkv ssskgsdght lafttegevf
      481 swgdgdygkl ghgnsstqky pkliqgplqg kvvvcvsagy rhsaavtedg elytwgegdf
      541 grlghgdsns rniptlvkdi snvgevscgs shtialskdg rtvwsfgggd ngklghgdtn
      601 rvykpkviea lqgmfirkvc agsqsslalt stgqvyawgc gaclgcgsse atalrpklie
      661 elaatrivdv sigdshclal shdnevyawg nnsmgqcgqg nstgpitkpk kvsgldgiai
      721 qqisagtshs lawtalprdr qvvawhrpyc vdleestfsh lrsflerycd kinseipplp
      781 fpssrehhsf lklclkllsn hlalalaggv atsilgrqag plrnllfrlm dstvpdeiqe
      841 vvietlsvga tmllpplrer mellhsllpq gpdrweslsk gqrmqldiil tslqdhthva
      901 sllgysspsd aadlssvctg ygnlsdqpyg tqschpdthl aeilmktllr nlgfytdqaf
      961 geleknsdkf llgtsssens qpahlhellc slqkqllafc hinnisenss svallhkhlq
     1021 lllphatdiy srsanllkes pwngsvgekl rdviyvsaag smlcqivnsl lllpvsvarp
     1081 llsylldllp pldclnrllp aadlledqel qwplhggpel idpaglplpq paqswvwlvd
     1141 lertiallig rclggmlqgs pvspeeqdta ywmktplfsd gvemdtpqld kcmsclleva
     1201 lsgneeqkpf dyklrpeiav yvdlalgcsk eparslwism qdyavskdwd satlsnesll
     1261 dtvsrfvlaa llkhtnllsq acgesryqpg khlsevyrcv ykvrsrllac knleliqtrs
     1321 ssrdrwisen qdsadvdpqe hsftrtidee aemeeqaerd reeghpeped eeeerehevm
     1381 tagnlvfvlh vteifqcfls arevarsrdr drmnsgagsg araddpppqs qqerrvstdl
     1441 pegqdvytaa cnsvihrcal lilgvspvid elqkrreegq lqqpstsase ggglmtrses
     1501 ltaesrlvht spnyrliksr sesdlsqpes deegyalsgr rnvdldlaas hrkrvylllf
     1561 gqlsprkkks fkqvhdgpmh sqleslsdsw arlkhsrdwl cnssysfesd fdltkslgvh
     1621 tlienvvsfv sgdvgnapgf kepeesmsts pqasiiameq qqlraelrle alhqilvlls
     1681 gmeekgsisl agsrlssgfq sstlltsvrl qflagcfglg tvghtggkge sgrlhhyqdg
     1741 iraakrniqi eiqvavhkiy qqlsatlera lqankhhiea qqrlllvtvf alsvhyqpvd
     1801 vslaistgll nvlsqlcgtd tmlgqplqll pktgvsqlst alkvastrll qilaittgty
     1861 adklspkvvq slldllcsql knllsqtgvl hmasfgegeq edgeeeekkv dssgetekkd
     1921 fraalrkqha aelhlgdflv flrrvvsska iqskmaspkw tevllniasq kcssgiplvg
     1981 nlrtrllalh vleavlpace sgveddqmaq iverlfslls dcmwetpiaq akhaiqikek
     2041 eqeiklqkqg eleeedenlp iqevsfdpek aqcclvengq ilthgsggkg yglastgvts
     2101 gcyqwkfyiv kenrgnegtc vgvsrwpvhd fnhrttsdmw lyraysgnly hngeqtltls
     2161 sftqgdfitc vldmeartis fgkngeepkl afedvdaael ypcvmfyssn pgekvkicdm
     2221 qmrgtprdll pgdpicspva avlaeatiql irilhrtdrw tycinkkmme rlhkikicik
     2281 esgqklkksr svqsreenem reekeskeee kgkhtrhgla dlselqlrtl cievwpvlav
     2341 iggvdaglrv ggrcvhkqtg rhatllgvvk egstsakvqw deaeitisdt plynlepcep
     2401 lpfdvarfrg ltasvlldlt yltgvhedmg kqstkrhekk hrheseekgd veqkpesesa
     2461 ldmrtgltsd dvksqsttss kseneiasfs ldptlpsves qhqitegkrk nhehmsknhd
     2521 vaqseiravq lsylylgamk slsallgcsk yaelllipkv laenghnsdc asspvvhedv
     2581 emraalqflm rhmvkravmr spikralgla dleraqamiy klvvhglled qfggkikqei
     2641 dqqaeesdpa qqaqtpvtts psassttsfm sssledttta ttpvtdtetv pasespgvmp
     2701 lsllrqmfss yptttvlptr raqtppissl ptspsdevgr rqsltspdsq sarpanrtal
     2761 sdpssrlsts ppppaiavpl lemgfslrqi akameatgar geadaqnitv lamwmiehpg
     2821 hedeeepqsg stadsrpgaa vlgsggksnd pcylqspgdi psadaaemee gfsespdnld
     2881 htenaasgsg psargrsavt rrhkfdlaar tllaraagly rsvqahrnqs rregislqqd
     2941 pgalydfnld eeleidldde ameamfgqdl tsdndilgmw ipehvcesed reevvvcelc
     3001 ecsvvsfnqh mkrnhpgcgr sanrqgyrsn gsyvdgwfgg ecgsgnpyyl lcgtcrekyl
     3061 amktksksts serykgqapd ligkqdsvye edwdmldvde dekltgeeef ellagplgln
     3121 drrivpepvq fpdsdplgas vamvtatnsm eetlmqigch gsveksssgr itlgeqaaal
     3181 anphdrvval rrvtaaaqvl lartmvmral sllsvsgssc slaagleslg ltdirtlvrl
     3241 mclaaagrag lstspsamas tsersrgghs kankpiscla ylstavgcla snapsaakll
     3301 vqlctqnlis aatgvnlttv ddsiqrkflp sflrgiaeen klvtspnfvv tqalvallad
     3361 kgaklrpnyd ksevekkgli aqlyahpsyd psavgplela nalaacclss rlssqhrqwa
     3421 aqqlvrtlaa hdrdnqttlq tladmggdlr kcsfikleah qnrvmtcvwc nkkgllatsg
     3481 ndgtirvwnv tkkqyslqqt cvfnrlegda eeslgspsdp sfspvswsis gkylagalek
     3541 mvniwqvngg kglvdiqphw vsalawpeeg patawsgesp elllvgrmdg slglievvdv
     3601 stmhrreleh cyrkdvsvtc iawfsedrpf avgyfdgkll lgtkeplekg givlidahkd
     3661 tlismkwdpt ghilmtcake dsvklwgsis gcwcclhslc hpsivngiaw crlpgkgskl
     3721 qllmatgcqs glvcvwripq dttqtnvtsa egwweqesnc qdgyrkssga kcvyqlrghi
     3781 tpvrtvafss dglalvsggl gglmniwslr dgsvlqtvvi gsgaiqttvw ipevgvaacs
     3841 nrskdvlvvn ctaewaaanh vlatcrtalk qqgvlglnma pcmraflerl pmmlqeqyay
     3901 ekphvvcgdq lvhspymqcl aslavglhld qllcnppvpp hhqnclpdpa swnpnewawl
     3961 ecfsttikaa ealtngaqfp esftvpdlep vpedelvflm dnskwingmd eqimswatsr
     4021 pedwhlggkc dvylwgagrh gqlaeagrnv mvpaaapsfs qaqqvicgqn ctfviqangt
     4081 vlacgegsyg rlgqgnsddl hvltvisalq gfvvtqlvts cgsdghsmal tesgevfswg
     4141 dgdygklghg nsdrqrrprq iealqgeevv qmscgfkhsa vvtsdgklft fgngdygrlg
     4201 lgntsnkklp ervtalegyq igqvacglnh tlavsadgsm vwafgdgdyg klglgnstak
     4261 sspqkidvlc gigikkvacg tqfsvaltkd ghvytfgqdr liglpegrar nhnrpqqipv
     4321 lagviiedva vgaehtlala sngdvyawgs nsegqlglgh tnhvreptlv tglqgknvrq
     4381 isagrchsaa wtappvppra pgvsvplqlg lpdtvppqyg alrevsihtv rarlrllyhf
     4441 sdlmysswrl lnlspnnqns tshynagtwg ivqgqlrpll aprvytlpmv rsigktmvqg
     4501 knygpqitvk ristrgrkck pifvqiarqv vklnasdlrl psrawkvklv gegaddaggv
     4561 fddtitemcq eletgivdll ipspnataev gynrdrflfn psacldehlm qfkflgilmg
     4621 vairtkkpld lhlaplvwkq lccvpltled leevdllyvq tlnsilhied sgiteesfhe
     4681 mipldsfvgq sadgkmvpii pggnsipltf snrkeyvera ieyrlhemdr qvaavregms
     4741 wivpvpllsl ltakqleqmv cgmpeisvev lkkvvryrev deqhqlvqwf whtleefsne
     4801 ervlfmrfvs grsrlpanta disqrfqimk vdrpydslpt sqtcffqlrl ppyssqlvma
     4861 erlryainnc rsidmdnyml srnvdnaegs dtdy
//
LOCUS       XP_047289173            4892 aa            linear   PRI 05-AUG-2025
DEFINITION  putative E3 ubiquitin-protein ligase HERC1 isoform X7 [Homo
            sapiens].
ACCESSION   XP_047289173
VERSION     XP_047289173.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433217.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4892
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4892
                     /product="putative E3 ubiquitin-protein ligase HERC1
                     isoform X7"
                     /calculated_mol_wt=535738
     Region          374..703
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          683..733
                     /region_name="RCC1"
                     /note="Regulator of chromosome condensation (RCC1) repeat;
                     pfam00415"
                     /db_xref="CDD:395335"
     Region          2063..2220
                     /region_name="SPRY_HERC1"
                     /note="SPRY domain in HERC1; cd12881"
                     /db_xref="CDD:293939"
     Region          2784..2827
                     /region_name="UBA_HERC1"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC1 and similar proteins; cd14401"
                     /db_xref="CDD:270584"
     Region          <3418..3809
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          3463..3506
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3520..3555
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3560..3607
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3616..3651
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3660..3696
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3703..3734
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3781..3817
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          4030..4366
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          4504..4872
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4509,4550,4561,4628,4806,4836..4837,4840..4844,4864,
                     4871)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4656,4659..4660,4662..4663,4666,4674,4676,
                     4680..4681,4683,4692,4697,4714,4718)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4892
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /coded_by="XM_047433217.1:154..14832"
                     /db_xref="GeneID:8925"
                     /db_xref="HGNC:HGNC:4867"
                     /db_xref="MIM:605109"
ORIGIN      
        1 matmippvkl kwlehlnssw itedsesiat regvavlysk lvsnkevvpl pqqvlclkgp
       61 qlpdferesl ssdeqdhyld allssqlala kmvcsdspfa galrkrllvl qrvfyalsnk
      121 yhdkgkvkqq qhspesssgs advhsvserp rsstdaliem gvrtglsllf allrqswmmp
      181 vsgpglslcn dvihtaievv sslpplslan eskippmgld clsqvttflk gvtipnsgad
      241 tlgrrlasel llglaaqrgs lryllewiem algasavvht mekgkllssq egmisfdcfm
      301 tilmqmrrsl gssadrsqwr eptrtsdglc slyeaalclf eevcrmasdy srtcaspdsi
      361 qtgdapivse tcevyvwgsn sshqlvegtq ekilqpklap sfsdaqtiea gqyctfvist
      421 dgsvracgkg sygrlglgds nnqstlkklt fephrsikkv ssskgsdght lafttegevf
      481 swgdgdygkl ghgnsstqky pkliqgplqg kvvvcvsagy rhsaavtedg elytwgegdf
      541 grlghgdsns rniptlvkdi snvgevscgs shtialskdg rtvwsfgggd ngklghgdtn
      601 rvykpkviea lqgmfirkvc agsqsslalt stgqvyawgc gaclgcgsse atalrpklie
      661 elaatrivdv sigdshclal shdnevyawg nnsmgqcgqg nstgpitkpk kvsgldgiai
      721 qqisagtshs lawtalprdr qvvawhrpyc vdleestfsh lrsflerycd kinseipplp
      781 fpssrehhsf lklclkllsn hlalalaggv atsilgrqag plrnllfrlm dstvpdeiqe
      841 vvietlsvga tmllpplrer mellhsllpq gpdrweslsk gqrmqldiil tslqdhthva
      901 sllgysspsd aadlssvctg ygnlsdqpyg tqschpdthl aeilmktllr nlgfytdqaf
      961 geleknsdkf llgtsssens qpahlhellc slqkqllafc hinnisenss svallhkhlq
     1021 lllphatdiy srsanllkes pwngsvgekl rdviyvsaag smlcqivnsl lllpvsvarp
     1081 llsylldllp pldclnrllp aadlledqel qwplhggpel idpaglplpq paqswvwlvd
     1141 lertiallig rclggmlqgs pvspeeqdta ywmktplfsd gvemdtpqld kcmsclleva
     1201 lsgneeqkpf dyklrpeiav yvdlalgcsk eparslwism qdyavskdwd satlsnesll
     1261 dtvsrfvlaa llkhtnllsq acgesryqpg khlsevyrcv ykvrsrllac knleliqtrs
     1321 ssrdrwisen qdsadvdpqe hsftrtidee aemeeqaerd reeghpeped eeeerehevm
     1381 tagnlvfvlh vteifqcfls arevarsrdr drmnsgagsg araddpppqs qqerrvstdl
     1441 pegqdvytaa cnsvihrcal lilgvspvid elqkrreegq lqqpstsase ggglmtrses
     1501 ltaesrlvht spnyrliksr sesdlsqpes deegyalsgr rnvdldlaas hrkrvylllf
     1561 gqlsprkkks fkqvhdgpmh sqleslsdsw arlkhsrdwl cnssysfesd fdltkslgvh
     1621 tlienvvsfv sgdvgnapgf kepeesmsts pqasiiameq qqlraelrle alhqilvlls
     1681 gmeekgsisl agsrlssgfq sstlltsvrl qflagcfglg tvghtggkge sgrlhhyqdg
     1741 iraakrniqi eiqvavhkiy qqlsatlera lqankhhiea qqrlllvtvf alsvhyqpvd
     1801 vslaistgll nvlsqlcgtd tmlgqplqll pktgvsqlst alkvastrll qilaittgty
     1861 adklspkvvq slldllcsql knllsqtgvl hmasfgegeq edgeeeekkv dssgetekkd
     1921 fraalrkqha aelhlgdflv flrrvvsska iqskmaspkw tevllniasq kcssgiplvg
     1981 nlrtrllalh vleavlpace sgveddqmaq iverlfslls dcmwetpiaq akhaiqikek
     2041 eqeiklqkqg eleeedenlp iqevsfdpek aqcclvengq ilthgsggkg yglastgvts
     2101 gcyqwkfyiv kenrgnegtc vgvsrwpvhd fnhrttsdmw lyraysgnly hngeqtltls
     2161 sftqgdfitc vldmeartis fgkngeepkl afedvdaael ypcvmfyssn pgekvkicdm
     2221 qmrgtprdll pgdpicspva avlaeatiql irilhrtdrw tycinkkmme rlhkikicik
     2281 esgqklkksr svqsreenem reekeskeee kgkhtrhgla dlselqlrtl cievwpvlav
     2341 iggvdaglrv ggrcvhkqtg rhatllgvvk egstsakvqw deaeitisfp tfwspsdtpl
     2401 ynlepceplp fdvarfrglt asvlldltyl tgvhedmgkq stkrhekkhr heseekgdve
     2461 qkpesesald mrtgltsddv ksqsttssks eneiasfsld ptlpsvesqh qitegkrknh
     2521 ehmsknhdva qseiravqls ylylgamksl sallgcskya elllipkvla enghnsdcas
     2581 spvvhedvem raalqflmrh mvkravmrsp ikralgladl eraqamiykl vvhglledqf
     2641 ggkikqeidq qaeesdpaqq aqtpvttsps assttsfmss sledtttatt pvtdtetvpa
     2701 sespgvmpls llrqmfssyp tttvlptrra qtppisslpt spsdevgrrq sltspdsqsa
     2761 rpanrtalsd pssrlstspp ppaiavplle mgfslrqiak ameatgarge adaqnitvla
     2821 mwmiehpghe deeepqsgst adsrpgaavl gsggksndpc ylqspgdips adaaemeegf
     2881 sespdnldht enaasgsgps argrsavtrr hkfdlaartl laraaglyrs vqahrnqsrr
     2941 egislqqdpg alydfnldee leidlddeam eamfgqdlts dndilgmwip evldwptwhv
     3001 cesedreevv vcelcecsvv sfnqhmkrnh pgcgrsanrq gyrsngsyvd gwfggecgsg
     3061 npyyllcgtc rekylamktk skstsseryk gqapdligkq dsvyeedwdm ldvdedeklt
     3121 geeefellag plglndrriv pepvqfpdsd plgasvamvt atnsmeetlm qigchgsvek
     3181 sssgritlge qaaalanphd rvvalrrvta aaqvllartm vmralsllsv sgsscslaag
     3241 leslgltdir tlvrlmclaa agraglstsp samastsers rgghskankp isclaylsta
     3301 vgclasnaps aakllvqlct qnlisaatgv nlttvddsiq rkflpsflrg iaeenklvts
     3361 pnfvvtqalv alladkgakl rpnydkseve kkgplelana laacclssrl ssqhrqwaaq
     3421 qlvrtlaahd rdnqttlqtl admggdlrkc sfikleahqn rvmtcvwcnk kgllatsgnd
     3481 gtirvwnvtk kqyslqqtcv fnrlegdaee slgspsdpsf spvswsisgk ylagalekmv
     3541 niwqvnggkg lvdiqphwvs alawpeegpa tawsgespel llvgrmdgsl glievvdvst
     3601 mhrrelehcy rkdvsvtcia wfsedrpfav gyfdgklllg tkeplekggi vlidahkdtl
     3661 ismkwdptgh ilmtcakeds vklwgsisgc wcclhslchp sivngiawcr lpgkgsklql
     3721 lmatgcqsgl vcvwripqdt tqtnvtsaeg wweqesncqd gyrkssgakc vyqlrghitp
     3781 vrtvafssdg lalvsgglgg lmniwslrdg svlqtvvigs gaiqttvwip evgvaacsnr
     3841 skdvlvvnct aewaaanhvl atcrtalkqq gvlglnmapc mraflerlpm mlqeqyayek
     3901 phvvcgdqlv hspymqclas lavglhldql lcnppvpphh qnclpdpasw npnewawlec
     3961 fsttikaaea ltngaqfpes ftvpdlepvp edelvflmdn skwingmdeq imswatsrpe
     4021 dwhlggkcdv ylwgagrhgq laeagrnvmv paaapsfsqa qqvicgqnct fviqangtvl
     4081 acgegsygrl gqgnsddlhv ltvisalqgf vvtqlvtscg sdghsmalte sgevfswgdg
     4141 dygklghgns drqrrprqie alqgeevvqm scgfkhsavv tsdgklftfg ngdygrlglg
     4201 ntsnkklper vtalegyqig qvacglnhtl avsadgsmvw afgdgdygkl glgnstakss
     4261 pqkidvlcgi gikkvacgtq fsvaltkdgh vytfgqdrli glpegrarnh nrpqqipvla
     4321 gviiedvavg aehtlalasn gdvyawgsns egqlglghtn hvreptlvtg lqgknvrqis
     4381 agrchsaawt appvpprapg vsvplqlglp dtvppqygal revsihtvra rlrllyhfsd
     4441 lmysswrlln lspnnqnsts hynagtwgiv qgqlrpllap rvytlpmvrs igktmvqgkn
     4501 ygpqitvkri strgrkckpi fvqiarqvvk lnasdlrlps rawkvklvge gaddaggvfd
     4561 dtitemcqel etgivdllip spnataevgy nrdrflfnps acldehlmqf kflgilmgva
     4621 irtkkpldlh laplvwkqlc cvpltledle evdllyvqtl nsilhiedsg iteesfhemi
     4681 pldsfvgqsa dgkmvpiipg gnsipltfsn rkeyveraie yrlhemdrqv aavregmswi
     4741 vpvpllsllt akqleqmvcg mpeisvevlk kvvryrevde qhqlvqwfwh tleefsneer
     4801 vlfmrfvsgr srlpantadi sqrfqimkvd rpydslptsq tcffqlrlpp yssqlvmaer
     4861 lryainncrs idmdnymlsr nvdnaegsdt dy
//
LOCUS       XP_016878191            4892 aa            linear   PRI 05-AUG-2025
DEFINITION  putative E3 ubiquitin-protein ligase HERC1 isoform X8 [Homo
            sapiens].
ACCESSION   XP_016878191
VERSION     XP_016878191.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022702.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4892
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4892
                     /product="putative E3 ubiquitin-protein ligase HERC1
                     isoform X8"
                     /calculated_mol_wt=535488
     Region          374..703
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          683..733
                     /region_name="RCC1"
                     /note="Regulator of chromosome condensation (RCC1) repeat;
                     pfam00415"
                     /db_xref="CDD:395335"
     Region          2041..2198
                     /region_name="SPRY_HERC1"
                     /note="SPRY domain in HERC1; cd12881"
                     /db_xref="CDD:293939"
     Region          2762..2805
                     /region_name="UBA_HERC1"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC1 and similar proteins; cd14401"
                     /db_xref="CDD:270584"
     Region          <3418..3809
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          3463..3506
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3520..3555
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3560..3607
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3616..3651
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3660..3696
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3703..3734
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3781..3817
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          4030..4366
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          4504..4872
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4509,4550,4561,4628,4806,4836..4837,4840..4844,4864,
                     4871)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4656,4659..4660,4662..4663,4666,4674,4676,
                     4680..4681,4683,4692,4697,4714,4718)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4892
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /coded_by="XM_017022702.2:149..14827"
                     /db_xref="GeneID:8925"
                     /db_xref="HGNC:HGNC:4867"
                     /db_xref="MIM:605109"
ORIGIN      
        1 matmippvkl kwlehlnssw itedsesiat regvavlysk lvsnkevvpl pqqvlclkgp
       61 qlpdferesl ssdeqdhyld allssqlala kmvcsdspfa galrkrllvl qrvfyalsnk
      121 yhdkgkvkqq qhspesssgs advhsvserp rsstdaliem gvrtglsllf allrqswmmp
      181 vsgpglslcn dvihtaievv sslpplslan eskippmgld clsqvttflk gvtipnsgad
      241 tlgrrlasel llglaaqrgs lryllewiem algasavvht mekgkllssq egmisfdcfm
      301 tilmqmrrsl gssadrsqwr eptrtsdglc slyeaalclf eevcrmasdy srtcaspdsi
      361 qtgdapivse tcevyvwgsn sshqlvegtq ekilqpklap sfsdaqtiea gqyctfvist
      421 dgsvracgkg sygrlglgds nnqstlkklt fephrsikkv ssskgsdght lafttegevf
      481 swgdgdygkl ghgnsstqky pkliqgplqg kvvvcvsagy rhsaavtedg elytwgegdf
      541 grlghgdsns rniptlvkdi snvgevscgs shtialskdg rtvwsfgggd ngklghgdtn
      601 rvykpkviea lqgmfirkvc agsqsslalt stgqvyawgc gaclgcgsse atalrpklie
      661 elaatrivdv sigdshclal shdnevyawg nnsmgqcgqg nstgpitkpk kvsgldgiai
      721 qqisagtshs lawtalprdr qvvawhrpyc vdleestfsh lrsflerycd kinseipplp
      781 fpssrehhsf lklclkllsn hlalalaggv atsilgrqag plrnllfrlm dstvpdeiqe
      841 vvietlsvga tmllpplrer mellhsllpq gpdrweslsk gqrmqldiil tslqdhthva
      901 sllgysspsd aadlssvctg ygnlsdqpyg tqschpdthl aeilmktllr nlgfytdqaf
      961 geleknsdkf llgtsssens qpahlhellc slqkqllafc hinnisenss svallhkhlq
     1021 lllphatdiy srsanllkes pwngsvgekl rdviyvsaag smlcqivnsl lllpvsvarp
     1081 llsylldllp pldclnrllp aadlledqel qwplhggpel idpaglplpq paqswvwlvd
     1141 lertiallig rclggmlqgs pvspeeqdta ywmktplfsd gvemdtpqld kcmsclleva
     1201 lsgneeqkpf dyklrpeiav yvdlalgcsk eparslwism qdyavskdwd satlsnesll
     1261 dtvsrfvlaa llkhtnllsq acgesryqpg khlsevyrcv ykvrsrllac knleliqtrs
     1321 ssrdrwisen qdsadvdpqe hsftrtidee aemeeqaerd reeghpeped eeeerehevm
     1381 tagnlvfvlh vteifqcfls arevarsrdr drmnsgagsg araddpppqs qqerrvstdl
     1441 pegqdvytaa cnsvihrcal lilgvspvid elqkrreegq lqqpstsase ggglmtrses
     1501 ltaesrlvht spnyrliksr sesdlsqpes deegyalsgr rnvdldlaas hrkrgpmhsq
     1561 leslsdswar lkhsrdwlcn ssysfesdfd ltkslgvhtl ienvvsfvsg dvgnapgfke
     1621 peesmstspq asiiameqqq lraelrleal hqilvllsgm eekgsislag srlssgfqss
     1681 tlltsvrlqf lagcfglgtv ghtggkgesg rlhhyqdgir aakrniqiei qvavhkiyqq
     1741 lsatleralq ankhhieaqq rlllvtvfal svhyqpvdvs laistgllnv lsqlcgtdtm
     1801 lgqplqllpk tgvsqlstal kvastrllqi laittgtyad klspkvvqsl ldllcsqlkn
     1861 llsqtgvlhm asfgegeqed geeeekkvds sgetekkdfr aalrkqhaae lhlgdflvfl
     1921 rrvvsskaiq skmaspkwte vllniasqkc ssgiplvgnl rtrllalhvl eavlpacesg
     1981 veddqmaqiv erlfsllsdc mwetpiaqak haiqikekeq eiklqkqgel eeedenlpiq
     2041 evsfdpekaq cclvengqil thgsggkgyg lastgvtsgc yqwkfyivke nrgnegtcvg
     2101 vsrwpvhdfn hrttsdmwly raysgnlyhn geqtltlssf tqgdfitcvl dmeartisfg
     2161 kngeepklaf edvdaaelyp cvmfyssnpg ekvkicdmqm rgtprdllpg dpicspvaav
     2221 laeatiqlir ilhrtdrwty cinkkmmerl hkikicikes gqklkksrsv qsreenemre
     2281 ekeskeeekg khtrhgladl selqlrtlci evwpvlavig gvdaglrvgg rcvhkqtgrh
     2341 atllgvvkeg stsakvqwde aeitisfptf wspsdtplyn lepceplpfd varfrgltas
     2401 vlldltyltg vhedmgkqst krhekkhrhe seekgdveqk pesesaldmr tgltsddvks
     2461 qsttssksen eiasfsldpt lpsvesqhqi tegkrknheh msknhdvaqs eiravqlsyl
     2521 ylgamkslsa llgcskyael llipkvlaen ghnsdcassp vvhedvemra alqflmrhmv
     2581 kravmrspik ralgladler aqamiyklvv hglledqfgg kikqeidqqa eesdpaqqaq
     2641 tpvttspsas sttsfmsssl edtttattpv tdtetvpase spgvmplsll rqmfssyptt
     2701 tvlptrraqt ppisslptsp sdevgrrqsl tspdsqsarp anrtalsdps srlstspppp
     2761 aiavpllemg fslrqiakam eatgargead aqnitvlamw miehpghede eepqsgstad
     2821 srpgaavlgs ggksndpcyl qspgdipsad aaemeegfse spdnldhten aasgsgpsar
     2881 grsavtrrhk fdlaartlla raaglyrsvq ahrnqsrreg islqqdpgal ydfnldeele
     2941 idlddeamea mfgqdltsdn dilgmwipev ldwptwhvce sedreevvvc elcecsvvsf
     3001 nqhmkrnhpg cgrsanrqgy rsngsyvdgw fggecgsgnp yyllcgtcre kylamktksk
     3061 stsserykgq apdligkqds vyeedwdmld vdedekltge eefellagpl glndrrivpe
     3121 pvqfpdsdpl gasvamvtat nsmeetlmqi elcfsgchgs veksssgrit lgeqaaalan
     3181 phdrvvalrr vtaaaqvlla rtmvmralsl lsvsgsscsl aagleslglt dirtlvrlmc
     3241 laaagragls tspsamasts ersrgghska nkpisclayl stavgclasn apsaakllvq
     3301 lctqnlisaa tgvnlttvdd siqrkflpsf lrgiaeenkl vtspnfvvtq alvalladkg
     3361 aklrpnydks evekkgliaq lyahpsydps avgplelana laacclssrl ssqhrqwaaq
     3421 qlvrtlaahd rdnqttlqtl admggdlrkc sfikleahqn rvmtcvwcnk kgllatsgnd
     3481 gtirvwnvtk kqyslqqtcv fnrlegdaee slgspsdpsf spvswsisgk ylagalekmv
     3541 niwqvnggkg lvdiqphwvs alawpeegpa tawsgespel llvgrmdgsl glievvdvst
     3601 mhrrelehcy rkdvsvtcia wfsedrpfav gyfdgklllg tkeplekggi vlidahkdtl
     3661 ismkwdptgh ilmtcakeds vklwgsisgc wcclhslchp sivngiawcr lpgkgsklql
     3721 lmatgcqsgl vcvwripqdt tqtnvtsaeg wweqesncqd gyrkssgakc vyqlrghitp
     3781 vrtvafssdg lalvsgglgg lmniwslrdg svlqtvvigs gaiqttvwip evgvaacsnr
     3841 skdvlvvnct aewaaanhvl atcrtalkqq gvlglnmapc mraflerlpm mlqeqyayek
     3901 phvvcgdqlv hspymqclas lavglhldql lcnppvpphh qnclpdpasw npnewawlec
     3961 fsttikaaea ltngaqfpes ftvpdlepvp edelvflmdn skwingmdeq imswatsrpe
     4021 dwhlggkcdv ylwgagrhgq laeagrnvmv paaapsfsqa qqvicgqnct fviqangtvl
     4081 acgegsygrl gqgnsddlhv ltvisalqgf vvtqlvtscg sdghsmalte sgevfswgdg
     4141 dygklghgns drqrrprqie alqgeevvqm scgfkhsavv tsdgklftfg ngdygrlglg
     4201 ntsnkklper vtalegyqig qvacglnhtl avsadgsmvw afgdgdygkl glgnstakss
     4261 pqkidvlcgi gikkvacgtq fsvaltkdgh vytfgqdrli glpegrarnh nrpqqipvla
     4321 gviiedvavg aehtlalasn gdvyawgsns egqlglghtn hvreptlvtg lqgknvrqis
     4381 agrchsaawt appvpprapg vsvplqlglp dtvppqygal revsihtvra rlrllyhfsd
     4441 lmysswrlln lspnnqnsts hynagtwgiv qgqlrpllap rvytlpmvrs igktmvqgkn
     4501 ygpqitvkri strgrkckpi fvqiarqvvk lnasdlrlps rawkvklvge gaddaggvfd
     4561 dtitemcqel etgivdllip spnataevgy nrdrflfnps acldehlmqf kflgilmgva
     4621 irtkkpldlh laplvwkqlc cvpltledle evdllyvqtl nsilhiedsg iteesfhemi
     4681 pldsfvgqsa dgkmvpiipg gnsipltfsn rkeyveraie yrlhemdrqv aavregmswi
     4741 vpvpllsllt akqleqmvcg mpeisvevlk kvvryrevde qhqlvqwfwh tleefsneer
     4801 vlfmrfvsgr srlpantadi sqrfqimkvd rpydslptsq tcffqlrlpp yssqlvmaer
     4861 lryainncrs idmdnymlsr nvdnaegsdt dy
//
LOCUS       XP_047289174            4892 aa            linear   PRI 05-AUG-2025
DEFINITION  putative E3 ubiquitin-protein ligase HERC1 isoform X8 [Homo
            sapiens].
ACCESSION   XP_047289174
VERSION     XP_047289174.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433218.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4892
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4892
                     /product="putative E3 ubiquitin-protein ligase HERC1
                     isoform X8"
                     /calculated_mol_wt=535488
     Region          374..703
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          683..733
                     /region_name="RCC1"
                     /note="Regulator of chromosome condensation (RCC1) repeat;
                     pfam00415"
                     /db_xref="CDD:395335"
     Region          2041..2198
                     /region_name="SPRY_HERC1"
                     /note="SPRY domain in HERC1; cd12881"
                     /db_xref="CDD:293939"
     Region          2762..2805
                     /region_name="UBA_HERC1"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC1 and similar proteins; cd14401"
                     /db_xref="CDD:270584"
     Region          <3418..3809
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          3463..3506
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3520..3555
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3560..3607
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3616..3651
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3660..3696
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3703..3734
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3781..3817
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          4030..4366
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          4504..4872
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4509,4550,4561,4628,4806,4836..4837,4840..4844,4864,
                     4871)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4656,4659..4660,4662..4663,4666,4674,4676,
                     4680..4681,4683,4692,4697,4714,4718)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4892
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /coded_by="XM_047433218.1:154..14832"
                     /db_xref="GeneID:8925"
                     /db_xref="HGNC:HGNC:4867"
                     /db_xref="MIM:605109"
ORIGIN      
        1 matmippvkl kwlehlnssw itedsesiat regvavlysk lvsnkevvpl pqqvlclkgp
       61 qlpdferesl ssdeqdhyld allssqlala kmvcsdspfa galrkrllvl qrvfyalsnk
      121 yhdkgkvkqq qhspesssgs advhsvserp rsstdaliem gvrtglsllf allrqswmmp
      181 vsgpglslcn dvihtaievv sslpplslan eskippmgld clsqvttflk gvtipnsgad
      241 tlgrrlasel llglaaqrgs lryllewiem algasavvht mekgkllssq egmisfdcfm
      301 tilmqmrrsl gssadrsqwr eptrtsdglc slyeaalclf eevcrmasdy srtcaspdsi
      361 qtgdapivse tcevyvwgsn sshqlvegtq ekilqpklap sfsdaqtiea gqyctfvist
      421 dgsvracgkg sygrlglgds nnqstlkklt fephrsikkv ssskgsdght lafttegevf
      481 swgdgdygkl ghgnsstqky pkliqgplqg kvvvcvsagy rhsaavtedg elytwgegdf
      541 grlghgdsns rniptlvkdi snvgevscgs shtialskdg rtvwsfgggd ngklghgdtn
      601 rvykpkviea lqgmfirkvc agsqsslalt stgqvyawgc gaclgcgsse atalrpklie
      661 elaatrivdv sigdshclal shdnevyawg nnsmgqcgqg nstgpitkpk kvsgldgiai
      721 qqisagtshs lawtalprdr qvvawhrpyc vdleestfsh lrsflerycd kinseipplp
      781 fpssrehhsf lklclkllsn hlalalaggv atsilgrqag plrnllfrlm dstvpdeiqe
      841 vvietlsvga tmllpplrer mellhsllpq gpdrweslsk gqrmqldiil tslqdhthva
      901 sllgysspsd aadlssvctg ygnlsdqpyg tqschpdthl aeilmktllr nlgfytdqaf
      961 geleknsdkf llgtsssens qpahlhellc slqkqllafc hinnisenss svallhkhlq
     1021 lllphatdiy srsanllkes pwngsvgekl rdviyvsaag smlcqivnsl lllpvsvarp
     1081 llsylldllp pldclnrllp aadlledqel qwplhggpel idpaglplpq paqswvwlvd
     1141 lertiallig rclggmlqgs pvspeeqdta ywmktplfsd gvemdtpqld kcmsclleva
     1201 lsgneeqkpf dyklrpeiav yvdlalgcsk eparslwism qdyavskdwd satlsnesll
     1261 dtvsrfvlaa llkhtnllsq acgesryqpg khlsevyrcv ykvrsrllac knleliqtrs
     1321 ssrdrwisen qdsadvdpqe hsftrtidee aemeeqaerd reeghpeped eeeerehevm
     1381 tagnlvfvlh vteifqcfls arevarsrdr drmnsgagsg araddpppqs qqerrvstdl
     1441 pegqdvytaa cnsvihrcal lilgvspvid elqkrreegq lqqpstsase ggglmtrses
     1501 ltaesrlvht spnyrliksr sesdlsqpes deegyalsgr rnvdldlaas hrkrgpmhsq
     1561 leslsdswar lkhsrdwlcn ssysfesdfd ltkslgvhtl ienvvsfvsg dvgnapgfke
     1621 peesmstspq asiiameqqq lraelrleal hqilvllsgm eekgsislag srlssgfqss
     1681 tlltsvrlqf lagcfglgtv ghtggkgesg rlhhyqdgir aakrniqiei qvavhkiyqq
     1741 lsatleralq ankhhieaqq rlllvtvfal svhyqpvdvs laistgllnv lsqlcgtdtm
     1801 lgqplqllpk tgvsqlstal kvastrllqi laittgtyad klspkvvqsl ldllcsqlkn
     1861 llsqtgvlhm asfgegeqed geeeekkvds sgetekkdfr aalrkqhaae lhlgdflvfl
     1921 rrvvsskaiq skmaspkwte vllniasqkc ssgiplvgnl rtrllalhvl eavlpacesg
     1981 veddqmaqiv erlfsllsdc mwetpiaqak haiqikekeq eiklqkqgel eeedenlpiq
     2041 evsfdpekaq cclvengqil thgsggkgyg lastgvtsgc yqwkfyivke nrgnegtcvg
     2101 vsrwpvhdfn hrttsdmwly raysgnlyhn geqtltlssf tqgdfitcvl dmeartisfg
     2161 kngeepklaf edvdaaelyp cvmfyssnpg ekvkicdmqm rgtprdllpg dpicspvaav
     2221 laeatiqlir ilhrtdrwty cinkkmmerl hkikicikes gqklkksrsv qsreenemre
     2281 ekeskeeekg khtrhgladl selqlrtlci evwpvlavig gvdaglrvgg rcvhkqtgrh
     2341 atllgvvkeg stsakvqwde aeitisfptf wspsdtplyn lepceplpfd varfrgltas
     2401 vlldltyltg vhedmgkqst krhekkhrhe seekgdveqk pesesaldmr tgltsddvks
     2461 qsttssksen eiasfsldpt lpsvesqhqi tegkrknheh msknhdvaqs eiravqlsyl
     2521 ylgamkslsa llgcskyael llipkvlaen ghnsdcassp vvhedvemra alqflmrhmv
     2581 kravmrspik ralgladler aqamiyklvv hglledqfgg kikqeidqqa eesdpaqqaq
     2641 tpvttspsas sttsfmsssl edtttattpv tdtetvpase spgvmplsll rqmfssyptt
     2701 tvlptrraqt ppisslptsp sdevgrrqsl tspdsqsarp anrtalsdps srlstspppp
     2761 aiavpllemg fslrqiakam eatgargead aqnitvlamw miehpghede eepqsgstad
     2821 srpgaavlgs ggksndpcyl qspgdipsad aaemeegfse spdnldhten aasgsgpsar
     2881 grsavtrrhk fdlaartlla raaglyrsvq ahrnqsrreg islqqdpgal ydfnldeele
     2941 idlddeamea mfgqdltsdn dilgmwipev ldwptwhvce sedreevvvc elcecsvvsf
     3001 nqhmkrnhpg cgrsanrqgy rsngsyvdgw fggecgsgnp yyllcgtcre kylamktksk
     3061 stsserykgq apdligkqds vyeedwdmld vdedekltge eefellagpl glndrrivpe
     3121 pvqfpdsdpl gasvamvtat nsmeetlmqi elcfsgchgs veksssgrit lgeqaaalan
     3181 phdrvvalrr vtaaaqvlla rtmvmralsl lsvsgsscsl aagleslglt dirtlvrlmc
     3241 laaagragls tspsamasts ersrgghska nkpisclayl stavgclasn apsaakllvq
     3301 lctqnlisaa tgvnlttvdd siqrkflpsf lrgiaeenkl vtspnfvvtq alvalladkg
     3361 aklrpnydks evekkgliaq lyahpsydps avgplelana laacclssrl ssqhrqwaaq
     3421 qlvrtlaahd rdnqttlqtl admggdlrkc sfikleahqn rvmtcvwcnk kgllatsgnd
     3481 gtirvwnvtk kqyslqqtcv fnrlegdaee slgspsdpsf spvswsisgk ylagalekmv
     3541 niwqvnggkg lvdiqphwvs alawpeegpa tawsgespel llvgrmdgsl glievvdvst
     3601 mhrrelehcy rkdvsvtcia wfsedrpfav gyfdgklllg tkeplekggi vlidahkdtl
     3661 ismkwdptgh ilmtcakeds vklwgsisgc wcclhslchp sivngiawcr lpgkgsklql
     3721 lmatgcqsgl vcvwripqdt tqtnvtsaeg wweqesncqd gyrkssgakc vyqlrghitp
     3781 vrtvafssdg lalvsgglgg lmniwslrdg svlqtvvigs gaiqttvwip evgvaacsnr
     3841 skdvlvvnct aewaaanhvl atcrtalkqq gvlglnmapc mraflerlpm mlqeqyayek
     3901 phvvcgdqlv hspymqclas lavglhldql lcnppvpphh qnclpdpasw npnewawlec
     3961 fsttikaaea ltngaqfpes ftvpdlepvp edelvflmdn skwingmdeq imswatsrpe
     4021 dwhlggkcdv ylwgagrhgq laeagrnvmv paaapsfsqa qqvicgqnct fviqangtvl
     4081 acgegsygrl gqgnsddlhv ltvisalqgf vvtqlvtscg sdghsmalte sgevfswgdg
     4141 dygklghgns drqrrprqie alqgeevvqm scgfkhsavv tsdgklftfg ngdygrlglg
     4201 ntsnkklper vtalegyqig qvacglnhtl avsadgsmvw afgdgdygkl glgnstakss
     4261 pqkidvlcgi gikkvacgtq fsvaltkdgh vytfgqdrli glpegrarnh nrpqqipvla
     4321 gviiedvavg aehtlalasn gdvyawgsns egqlglghtn hvreptlvtg lqgknvrqis
     4381 agrchsaawt appvpprapg vsvplqlglp dtvppqygal revsihtvra rlrllyhfsd
     4441 lmysswrlln lspnnqnsts hynagtwgiv qgqlrpllap rvytlpmvrs igktmvqgkn
     4501 ygpqitvkri strgrkckpi fvqiarqvvk lnasdlrlps rawkvklvge gaddaggvfd
     4561 dtitemcqel etgivdllip spnataevgy nrdrflfnps acldehlmqf kflgilmgva
     4621 irtkkpldlh laplvwkqlc cvpltledle evdllyvqtl nsilhiedsg iteesfhemi
     4681 pldsfvgqsa dgkmvpiipg gnsipltfsn rkeyveraie yrlhemdrqv aavregmswi
     4741 vpvpllsllt akqleqmvcg mpeisvevlk kvvryrevde qhqlvqwfwh tleefsneer
     4801 vlfmrfvsgr srlpantadi sqrfqimkvd rpydslptsq tcffqlrlpp yssqlvmaer
     4861 lryainncrs idmdnymlsr nvdnaegsdt dy
//
LOCUS       XP_047289175            4892 aa            linear   PRI 05-AUG-2025
DEFINITION  putative E3 ubiquitin-protein ligase HERC1 isoform X8 [Homo
            sapiens].
ACCESSION   XP_047289175
VERSION     XP_047289175.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433219.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4892
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4892
                     /product="putative E3 ubiquitin-protein ligase HERC1
                     isoform X8"
                     /calculated_mol_wt=535488
     Region          374..703
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          683..733
                     /region_name="RCC1"
                     /note="Regulator of chromosome condensation (RCC1) repeat;
                     pfam00415"
                     /db_xref="CDD:395335"
     Region          2041..2198
                     /region_name="SPRY_HERC1"
                     /note="SPRY domain in HERC1; cd12881"
                     /db_xref="CDD:293939"
     Region          2762..2805
                     /region_name="UBA_HERC1"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC1 and similar proteins; cd14401"
                     /db_xref="CDD:270584"
     Region          <3418..3809
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          3463..3506
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3520..3555
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3560..3607
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3616..3651
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3660..3696
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3703..3734
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3781..3817
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          4030..4366
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          4504..4872
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4509,4550,4561,4628,4806,4836..4837,4840..4844,4864,
                     4871)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4656,4659..4660,4662..4663,4666,4674,4676,
                     4680..4681,4683,4692,4697,4714,4718)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4892
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /coded_by="XM_047433219.1:474..15152"
                     /db_xref="GeneID:8925"
                     /db_xref="HGNC:HGNC:4867"
                     /db_xref="MIM:605109"
ORIGIN      
        1 matmippvkl kwlehlnssw itedsesiat regvavlysk lvsnkevvpl pqqvlclkgp
       61 qlpdferesl ssdeqdhyld allssqlala kmvcsdspfa galrkrllvl qrvfyalsnk
      121 yhdkgkvkqq qhspesssgs advhsvserp rsstdaliem gvrtglsllf allrqswmmp
      181 vsgpglslcn dvihtaievv sslpplslan eskippmgld clsqvttflk gvtipnsgad
      241 tlgrrlasel llglaaqrgs lryllewiem algasavvht mekgkllssq egmisfdcfm
      301 tilmqmrrsl gssadrsqwr eptrtsdglc slyeaalclf eevcrmasdy srtcaspdsi
      361 qtgdapivse tcevyvwgsn sshqlvegtq ekilqpklap sfsdaqtiea gqyctfvist
      421 dgsvracgkg sygrlglgds nnqstlkklt fephrsikkv ssskgsdght lafttegevf
      481 swgdgdygkl ghgnsstqky pkliqgplqg kvvvcvsagy rhsaavtedg elytwgegdf
      541 grlghgdsns rniptlvkdi snvgevscgs shtialskdg rtvwsfgggd ngklghgdtn
      601 rvykpkviea lqgmfirkvc agsqsslalt stgqvyawgc gaclgcgsse atalrpklie
      661 elaatrivdv sigdshclal shdnevyawg nnsmgqcgqg nstgpitkpk kvsgldgiai
      721 qqisagtshs lawtalprdr qvvawhrpyc vdleestfsh lrsflerycd kinseipplp
      781 fpssrehhsf lklclkllsn hlalalaggv atsilgrqag plrnllfrlm dstvpdeiqe
      841 vvietlsvga tmllpplrer mellhsllpq gpdrweslsk gqrmqldiil tslqdhthva
      901 sllgysspsd aadlssvctg ygnlsdqpyg tqschpdthl aeilmktllr nlgfytdqaf
      961 geleknsdkf llgtsssens qpahlhellc slqkqllafc hinnisenss svallhkhlq
     1021 lllphatdiy srsanllkes pwngsvgekl rdviyvsaag smlcqivnsl lllpvsvarp
     1081 llsylldllp pldclnrllp aadlledqel qwplhggpel idpaglplpq paqswvwlvd
     1141 lertiallig rclggmlqgs pvspeeqdta ywmktplfsd gvemdtpqld kcmsclleva
     1201 lsgneeqkpf dyklrpeiav yvdlalgcsk eparslwism qdyavskdwd satlsnesll
     1261 dtvsrfvlaa llkhtnllsq acgesryqpg khlsevyrcv ykvrsrllac knleliqtrs
     1321 ssrdrwisen qdsadvdpqe hsftrtidee aemeeqaerd reeghpeped eeeerehevm
     1381 tagnlvfvlh vteifqcfls arevarsrdr drmnsgagsg araddpppqs qqerrvstdl
     1441 pegqdvytaa cnsvihrcal lilgvspvid elqkrreegq lqqpstsase ggglmtrses
     1501 ltaesrlvht spnyrliksr sesdlsqpes deegyalsgr rnvdldlaas hrkrgpmhsq
     1561 leslsdswar lkhsrdwlcn ssysfesdfd ltkslgvhtl ienvvsfvsg dvgnapgfke
     1621 peesmstspq asiiameqqq lraelrleal hqilvllsgm eekgsislag srlssgfqss
     1681 tlltsvrlqf lagcfglgtv ghtggkgesg rlhhyqdgir aakrniqiei qvavhkiyqq
     1741 lsatleralq ankhhieaqq rlllvtvfal svhyqpvdvs laistgllnv lsqlcgtdtm
     1801 lgqplqllpk tgvsqlstal kvastrllqi laittgtyad klspkvvqsl ldllcsqlkn
     1861 llsqtgvlhm asfgegeqed geeeekkvds sgetekkdfr aalrkqhaae lhlgdflvfl
     1921 rrvvsskaiq skmaspkwte vllniasqkc ssgiplvgnl rtrllalhvl eavlpacesg
     1981 veddqmaqiv erlfsllsdc mwetpiaqak haiqikekeq eiklqkqgel eeedenlpiq
     2041 evsfdpekaq cclvengqil thgsggkgyg lastgvtsgc yqwkfyivke nrgnegtcvg
     2101 vsrwpvhdfn hrttsdmwly raysgnlyhn geqtltlssf tqgdfitcvl dmeartisfg
     2161 kngeepklaf edvdaaelyp cvmfyssnpg ekvkicdmqm rgtprdllpg dpicspvaav
     2221 laeatiqlir ilhrtdrwty cinkkmmerl hkikicikes gqklkksrsv qsreenemre
     2281 ekeskeeekg khtrhgladl selqlrtlci evwpvlavig gvdaglrvgg rcvhkqtgrh
     2341 atllgvvkeg stsakvqwde aeitisfptf wspsdtplyn lepceplpfd varfrgltas
     2401 vlldltyltg vhedmgkqst krhekkhrhe seekgdveqk pesesaldmr tgltsddvks
     2461 qsttssksen eiasfsldpt lpsvesqhqi tegkrknheh msknhdvaqs eiravqlsyl
     2521 ylgamkslsa llgcskyael llipkvlaen ghnsdcassp vvhedvemra alqflmrhmv
     2581 kravmrspik ralgladler aqamiyklvv hglledqfgg kikqeidqqa eesdpaqqaq
     2641 tpvttspsas sttsfmsssl edtttattpv tdtetvpase spgvmplsll rqmfssyptt
     2701 tvlptrraqt ppisslptsp sdevgrrqsl tspdsqsarp anrtalsdps srlstspppp
     2761 aiavpllemg fslrqiakam eatgargead aqnitvlamw miehpghede eepqsgstad
     2821 srpgaavlgs ggksndpcyl qspgdipsad aaemeegfse spdnldhten aasgsgpsar
     2881 grsavtrrhk fdlaartlla raaglyrsvq ahrnqsrreg islqqdpgal ydfnldeele
     2941 idlddeamea mfgqdltsdn dilgmwipev ldwptwhvce sedreevvvc elcecsvvsf
     3001 nqhmkrnhpg cgrsanrqgy rsngsyvdgw fggecgsgnp yyllcgtcre kylamktksk
     3061 stsserykgq apdligkqds vyeedwdmld vdedekltge eefellagpl glndrrivpe
     3121 pvqfpdsdpl gasvamvtat nsmeetlmqi elcfsgchgs veksssgrit lgeqaaalan
     3181 phdrvvalrr vtaaaqvlla rtmvmralsl lsvsgsscsl aagleslglt dirtlvrlmc
     3241 laaagragls tspsamasts ersrgghska nkpisclayl stavgclasn apsaakllvq
     3301 lctqnlisaa tgvnlttvdd siqrkflpsf lrgiaeenkl vtspnfvvtq alvalladkg
     3361 aklrpnydks evekkgliaq lyahpsydps avgplelana laacclssrl ssqhrqwaaq
     3421 qlvrtlaahd rdnqttlqtl admggdlrkc sfikleahqn rvmtcvwcnk kgllatsgnd
     3481 gtirvwnvtk kqyslqqtcv fnrlegdaee slgspsdpsf spvswsisgk ylagalekmv
     3541 niwqvnggkg lvdiqphwvs alawpeegpa tawsgespel llvgrmdgsl glievvdvst
     3601 mhrrelehcy rkdvsvtcia wfsedrpfav gyfdgklllg tkeplekggi vlidahkdtl
     3661 ismkwdptgh ilmtcakeds vklwgsisgc wcclhslchp sivngiawcr lpgkgsklql
     3721 lmatgcqsgl vcvwripqdt tqtnvtsaeg wweqesncqd gyrkssgakc vyqlrghitp
     3781 vrtvafssdg lalvsgglgg lmniwslrdg svlqtvvigs gaiqttvwip evgvaacsnr
     3841 skdvlvvnct aewaaanhvl atcrtalkqq gvlglnmapc mraflerlpm mlqeqyayek
     3901 phvvcgdqlv hspymqclas lavglhldql lcnppvpphh qnclpdpasw npnewawlec
     3961 fsttikaaea ltngaqfpes ftvpdlepvp edelvflmdn skwingmdeq imswatsrpe
     4021 dwhlggkcdv ylwgagrhgq laeagrnvmv paaapsfsqa qqvicgqnct fviqangtvl
     4081 acgegsygrl gqgnsddlhv ltvisalqgf vvtqlvtscg sdghsmalte sgevfswgdg
     4141 dygklghgns drqrrprqie alqgeevvqm scgfkhsavv tsdgklftfg ngdygrlglg
     4201 ntsnkklper vtalegyqig qvacglnhtl avsadgsmvw afgdgdygkl glgnstakss
     4261 pqkidvlcgi gikkvacgtq fsvaltkdgh vytfgqdrli glpegrarnh nrpqqipvla
     4321 gviiedvavg aehtlalasn gdvyawgsns egqlglghtn hvreptlvtg lqgknvrqis
     4381 agrchsaawt appvpprapg vsvplqlglp dtvppqygal revsihtvra rlrllyhfsd
     4441 lmysswrlln lspnnqnsts hynagtwgiv qgqlrpllap rvytlpmvrs igktmvqgkn
     4501 ygpqitvkri strgrkckpi fvqiarqvvk lnasdlrlps rawkvklvge gaddaggvfd
     4561 dtitemcqel etgivdllip spnataevgy nrdrflfnps acldehlmqf kflgilmgva
     4621 irtkkpldlh laplvwkqlc cvpltledle evdllyvqtl nsilhiedsg iteesfhemi
     4681 pldsfvgqsa dgkmvpiipg gnsipltfsn rkeyveraie yrlhemdrqv aavregmswi
     4741 vpvpllsllt akqleqmvcg mpeisvevlk kvvryrevde qhqlvqwfwh tleefsneer
     4801 vlfmrfvsgr srlpantadi sqrfqimkvd rpydslptsq tcffqlrlpp yssqlvmaer
     4861 lryainncrs idmdnymlsr nvdnaegsdt dy
//
LOCUS       XP_047289176            4891 aa            linear   PRI 05-AUG-2025
DEFINITION  putative E3 ubiquitin-protein ligase HERC1 isoform X9 [Homo
            sapiens].
ACCESSION   XP_047289176
VERSION     XP_047289176.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433220.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4891
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4891
                     /product="putative E3 ubiquitin-protein ligase HERC1
                     isoform X9"
                     /calculated_mol_wt=535610
     Region          374..703
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          683..733
                     /region_name="RCC1"
                     /note="Regulator of chromosome condensation (RCC1) repeat;
                     pfam00415"
                     /db_xref="CDD:395335"
     Region          2062..2219
                     /region_name="SPRY_HERC1"
                     /note="SPRY domain in HERC1; cd12881"
                     /db_xref="CDD:293939"
     Region          2783..2826
                     /region_name="UBA_HERC1"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC1 and similar proteins; cd14401"
                     /db_xref="CDD:270584"
     Region          <3417..3808
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          3462..3505
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3519..3554
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3559..3606
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3615..3650
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3659..3695
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3702..3733
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3780..3816
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          4029..4365
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          4503..4871
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4508,4549,4560,4627,4805,4835..4836,4839..4843,4863,
                     4870)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4655,4658..4659,4661..4662,4665,4673,4675,
                     4679..4680,4682,4691,4696,4713,4717)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4891
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /coded_by="XM_047433220.1:154..14829"
                     /db_xref="GeneID:8925"
                     /db_xref="HGNC:HGNC:4867"
                     /db_xref="MIM:605109"
ORIGIN      
        1 matmippvkl kwlehlnssw itedsesiat regvavlysk lvsnkevvpl pqqvlclkgp
       61 qlpdferesl ssdeqdhyld allssqlala kmvcsdspfa galrkrllvl qrvfyalsnk
      121 yhdkgkvkqq qhspesssgs advhsvserp rsstdaliem gvrtglsllf allrqswmmp
      181 vsgpglslcn dvihtaievv sslpplslan eskippmgld clsqvttflk gvtipnsgad
      241 tlgrrlasel llglaaqrgs lryllewiem algasavvht mekgkllssq egmisfdcfm
      301 tilmqmrrsl gssadrsqwr eptrtsdglc slyeaalclf eevcrmasdy srtcaspdsi
      361 qtgdapivse tcevyvwgsn sshqlvegtq ekilqpklap sfsdaqtiea gqyctfvist
      421 dgsvracgkg sygrlglgds nnqstlkklt fephrsikkv ssskgsdght lafttegevf
      481 swgdgdygkl ghgnsstqky pkliqgplqg kvvvcvsagy rhsaavtedg elytwgegdf
      541 grlghgdsns rniptlvkdi snvgevscgs shtialskdg rtvwsfgggd ngklghgdtn
      601 rvykpkviea lqgmfirkvc agsqsslalt stgqvyawgc gaclgcgsse atalrpklie
      661 elaatrivdv sigdshclal shdnevyawg nnsmgqcgqg nstgpitkpk kvsgldgiai
      721 qqisagtshs lawtalprdr qvvawhrpyc vdleestfsh lrsflerycd kinseipplp
      781 fpssrehhsf lklclkllsn hlalalaggv atsilgrqag plrnllfrlm dstvpdeiqe
      841 vvietlsvga tmllpplrer mellhsllpq gpdrweslsk gqrmqldiil tslqdhthva
      901 sllgysspsd aadlssvctg ygnlsdqpyg tqschpdthl aeilmktllr nlgfytdqaf
      961 geleknsdkf llgtsssens qpahlhellc slqkqllafc hinnisenss svallhkhlq
     1021 lllphatdiy srsanllkes pwngsvgekl rdviyvsaag smlcqivnsl lllpvsvarp
     1081 llsylldllp pldclnrllp aadlledqel qwplhggpel idpaglplpq paqswvwlvd
     1141 lertiallig rclggmlqgs pvspeeqdta ywmktplfsd gvemdtpqld kcmsclleva
     1201 lsgneeqkpf dyklrpeiav yvdlalgcsk eparslwism qdyavskdwd satlsnesll
     1261 dtvsrfvlaa llkhtnllsq acgesryqpg khlsevyrcv ykvrsrllac knleliqtrs
     1321 ssrdrwisen qdsadvdpqe hsftrtidee aemeeqaerd reeghpeped eeeerehevm
     1381 tagnlvfvlh vteifqcfls arevarsrdr drmnsgagsg araddpppqs qqerrvstdl
     1441 pegqdvytaa cnsvihrcal lilgvspvid elqkrreegq lqqpstsase ggglmtrses
     1501 ltaesrlvht spnyrliksr sesdlsqpes deegyalsgr rnvdldlaas hrkrvylllf
     1561 gqlsprkkks fkqvhdgpmh sqleslsdsw arlkhsrdwl cnssysfesd fdltkslgvh
     1621 tlienvvsfv sgdvgnapgf kepeesmsts pqasiiameq qqlraelrle alhqilvlls
     1681 gmeekgsisl agsrlssgfq sstlltsvrl qflagcfglg tvghtggkge sgrlhhyqdg
     1741 iraakrniqi eiqvavhkiy qqlsatlera lqankhhiea qqrlllvtvf alsvhyqpvd
     1801 vslaistgll nvlsqlcgtd tmlgqplqll pktgvsqlst alkvastrll qilaittgty
     1861 adklspkvvq slldllcsql knllsqtgvl hmasfgegeq edgeeeekkv dssgetekkd
     1921 fraalrkqha aelhlgdflv flrrvvsska iqskmaspkw tevllniasq kcssgiplvg
     1981 nlrtrllalh vleavlpace sgveddqmaq iverlfslls dcmwetpiaq akhaiqikek
     2041 eqeiklqqge leeedenlpi qevsfdpeka qcclvengqi lthgsggkgy glastgvtsg
     2101 cyqwkfyivk enrgnegtcv gvsrwpvhdf nhrttsdmwl yraysgnlyh ngeqtltlss
     2161 ftqgdfitcv ldmeartisf gkngeepkla fedvdaaely pcvmfyssnp gekvkicdmq
     2221 mrgtprdllp gdpicspvaa vlaeatiqli rilhrtdrwt ycinkkmmer lhkikicike
     2281 sgqklkksrs vqsreenemr eekeskeeek gkhtrhglad lselqlrtlc ievwpvlavi
     2341 ggvdaglrvg grcvhkqtgr hatllgvvke gstsakvqwd eaeitisfpt fwspsdtply
     2401 nlepceplpf dvarfrglta svlldltylt gvhedmgkqs tkrhekkhrh eseekgdveq
     2461 kpesesaldm rtgltsddvk sqsttsskse neiasfsldp tlpsvesqhq itegkrknhe
     2521 hmsknhdvaq seiravqlsy lylgamksls allgcskyae lllipkvlae nghnsdcass
     2581 pvvhedvemr aalqflmrhm vkravmrspi kralgladle raqamiyklv vhglledqfg
     2641 gkikqeidqq aeesdpaqqa qtpvttspsa ssttsfmsss ledtttattp vtdtetvpas
     2701 espgvmplsl lrqmfssypt ttvlptrraq tppisslpts psdevgrrqs ltspdsqsar
     2761 panrtalsdp ssrlstsppp paiavpllem gfslrqiaka meatgargea daqnitvlam
     2821 wmiehpghed eeepqsgsta dsrpgaavlg sggksndpcy lqspgdipsa daaemeegfs
     2881 espdnldhte naasgsgpsa rgrsavtrrh kfdlaartll araaglyrsv qahrnqsrre
     2941 gislqqdpga lydfnldeel eidlddeame amfgqdltsd ndilgmwipe vldwptwhvc
     3001 esedreevvv celcecsvvs fnqhmkrnhp gcgrsanrqg yrsngsyvdg wfggecgsgn
     3061 pyyllcgtcr ekylamktks kstsserykg qapdligkqd svyeedwdml dvdedekltg
     3121 eeefellagp lglndrrivp epvqfpdsdp lgasvamvta tnsmeetlmq igchgsveks
     3181 ssgritlgeq aaalanphdr vvalrrvtaa aqvllartmv mralsllsvs gsscslaagl
     3241 eslgltdirt lvrlmclaaa graglstsps amastsersr gghskankpi sclaylstav
     3301 gclasnapsa akllvqlctq nlisaatgvn lttvddsiqr kflpsflrgi aeenklvtsp
     3361 nfvvtqalva lladkgaklr pnydksevek kgplelanal aacclssrls sqhrqwaaqq
     3421 lvrtlaahdr dnqttlqtla dmggdlrkcs fikleahqnr vmtcvwcnkk gllatsgndg
     3481 tirvwnvtkk qyslqqtcvf nrlegdaees lgspsdpsfs pvswsisgky lagalekmvn
     3541 iwqvnggkgl vdiqphwvsa lawpeegpat awsgespell lvgrmdgslg lievvdvstm
     3601 hrrelehcyr kdvsvtciaw fsedrpfavg yfdgklllgt keplekggiv lidahkdtli
     3661 smkwdptghi lmtcakedsv klwgsisgcw cclhslchps ivngiawcrl pgkgsklqll
     3721 matgcqsglv cvwripqdtt qtnvtsaegw weqesncqdg yrkssgakcv yqlrghitpv
     3781 rtvafssdgl alvsgglggl mniwslrdgs vlqtvvigsg aiqttvwipe vgvaacsnrs
     3841 kdvlvvncta ewaaanhvla tcrtalkqqg vlglnmapcm raflerlpmm lqeqyayekp
     3901 hvvcgdqlvh spymqclasl avglhldqll cnppvpphhq nclpdpaswn pnewawlecf
     3961 sttikaaeal tngaqfpesf tvpdlepvpe delvflmdns kwingmdeqi mswatsrped
     4021 whlggkcdvy lwgagrhgql aeagrnvmvp aaapsfsqaq qvicgqnctf viqangtvla
     4081 cgegsygrlg qgnsddlhvl tvisalqgfv vtqlvtscgs dghsmaltes gevfswgdgd
     4141 ygklghgnsd rqrrprqiea lqgeevvqms cgfkhsavvt sdgklftfgn gdygrlglgn
     4201 tsnkklperv talegyqigq vacglnhtla vsadgsmvwa fgdgdygklg lgnstakssp
     4261 qkidvlcgig ikkvacgtqf svaltkdghv ytfgqdrlig lpegrarnhn rpqqipvlag
     4321 viiedvavga ehtlalasng dvyawgsnse gqlglghtnh vreptlvtgl qgknvrqisa
     4381 grchsaawta ppvpprapgv svplqlglpd tvppqygalr evsihtvrar lrllyhfsdl
     4441 mysswrllnl spnnqnstsh ynagtwgivq gqlrpllapr vytlpmvrsi gktmvqgkny
     4501 gpqitvkris trgrkckpif vqiarqvvkl nasdlrlpsr awkvklvgeg addaggvfdd
     4561 titemcqele tgivdllips pnataevgyn rdrflfnpsa cldehlmqfk flgilmgvai
     4621 rtkkpldlhl aplvwkqlcc vpltledlee vdllyvqtln silhiedsgi teesfhemip
     4681 ldsfvgqsad gkmvpiipgg nsipltfsnr keyveraiey rlhemdrqva avregmswiv
     4741 pvpllsllta kqleqmvcgm peisvevlkk vvryrevdeq hqlvqwfwht leefsneerv
     4801 lfmrfvsgrs rlpantadis qrfqimkvdr pydslptsqt cffqlrlppy ssqlvmaerl
     4861 ryainncrsi dmdnymlsrn vdnaegsdtd y
//
LOCUS       XP_047289177            4891 aa            linear   PRI 05-AUG-2025
DEFINITION  putative E3 ubiquitin-protein ligase HERC1 isoform X10 [Homo
            sapiens].
ACCESSION   XP_047289177
VERSION     XP_047289177.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433221.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4891
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4891
                     /product="putative E3 ubiquitin-protein ligase HERC1
                     isoform X10"
                     /calculated_mol_wt=535609
     Region          374..703
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          683..733
                     /region_name="RCC1"
                     /note="Regulator of chromosome condensation (RCC1) repeat;
                     pfam00415"
                     /db_xref="CDD:395335"
     Region          2063..2220
                     /region_name="SPRY_HERC1"
                     /note="SPRY domain in HERC1; cd12881"
                     /db_xref="CDD:293939"
     Region          2784..2827
                     /region_name="UBA_HERC1"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC1 and similar proteins; cd14401"
                     /db_xref="CDD:270584"
     Region          <3417..3808
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          3462..3505
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3519..3554
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3559..3606
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3615..3650
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3659..3695
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3702..3733
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3780..3816
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          4029..4365
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          4503..4871
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4508,4549,4560,4627,4805,4835..4836,4839..4843,4863,
                     4870)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4655,4658..4659,4661..4662,4665,4673,4675,
                     4679..4680,4682,4691,4696,4713,4717)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4891
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /coded_by="XM_047433221.1:154..14829"
                     /db_xref="GeneID:8925"
                     /db_xref="HGNC:HGNC:4867"
                     /db_xref="MIM:605109"
ORIGIN      
        1 matmippvkl kwlehlnssw itedsesiat regvavlysk lvsnkevvpl pqqvlclkgp
       61 qlpdferesl ssdeqdhyld allssqlala kmvcsdspfa galrkrllvl qrvfyalsnk
      121 yhdkgkvkqq qhspesssgs advhsvserp rsstdaliem gvrtglsllf allrqswmmp
      181 vsgpglslcn dvihtaievv sslpplslan eskippmgld clsqvttflk gvtipnsgad
      241 tlgrrlasel llglaaqrgs lryllewiem algasavvht mekgkllssq egmisfdcfm
      301 tilmqmrrsl gssadrsqwr eptrtsdglc slyeaalclf eevcrmasdy srtcaspdsi
      361 qtgdapivse tcevyvwgsn sshqlvegtq ekilqpklap sfsdaqtiea gqyctfvist
      421 dgsvracgkg sygrlglgds nnqstlkklt fephrsikkv ssskgsdght lafttegevf
      481 swgdgdygkl ghgnsstqky pkliqgplqg kvvvcvsagy rhsaavtedg elytwgegdf
      541 grlghgdsns rniptlvkdi snvgevscgs shtialskdg rtvwsfgggd ngklghgdtn
      601 rvykpkviea lqgmfirkvc agsqsslalt stgqvyawgc gaclgcgsse atalrpklie
      661 elaatrivdv sigdshclal shdnevyawg nnsmgqcgqg nstgpitkpk kvsgldgiai
      721 qqisagtshs lawtalprdr qvvawhrpyc vdleestfsh lrsflerycd kinseipplp
      781 fpssrehhsf lklclkllsn hlalalaggv atsilgrqag plrnllfrlm dstvpdeiqe
      841 vvietlsvga tmllpplrer mellhsllpq gpdrweslsk gqrmqldiil tslqdhthva
      901 sllgysspsd aadlssvctg ygnlsdqpyg tqschpdthl aeilmktllr nlgfytdqaf
      961 geleknsdkf llgtsssens qpahlhellc slqkqllafc hinnisenss svallhkhlq
     1021 lllphatdiy srsanllkes pwngsvgekl rdviyvsaag smlcqivnsl lllpvsvarp
     1081 llsylldllp pldclnrllp aadlledqel qwplhggpel idpaglplpq paqswvwlvd
     1141 lertiallig rclggmlqgs pvspeeqdta ywmktplfsd gvemdtpqld kcmsclleva
     1201 lsgneeqkpf dyklrpeiav yvdlalgcsk eparslwism qdyavskdwd satlsnesll
     1261 dtvsrfvlaa llkhtnllsq acgesryqpg khlsevyrcv ykvrsrllac knleliqtrs
     1321 ssrdrwisen qdsadvdpqe hsftrtidee aemeeqaerd reeghpeped eeeerehevm
     1381 tagnlvfvlh vteifqcfls arevarsrdr drmnsgagsg araddpppqs qqerrvstdl
     1441 pegqdvytaa cnsvihrcal lilgvspvid elqkrreegq lqqpstsase ggglmtrses
     1501 ltaesrlvht spnyrliksr sesdlsqpes deegyalsgr rnvdldlaas hrkrvylllf
     1561 gqlsprkkks fkqvhdgpmh sqleslsdsw arlkhsrdwl cnssysfesd fdltkslgvh
     1621 tlienvvsfv sgdvgnapgf kepeesmsts pqasiiameq qqlraelrle alhqilvlls
     1681 gmeekgsisl agsrlssgfq sstlltsvrl qflagcfglg tvghtggkge sgrlhhyqdg
     1741 iraakrniqi eiqvavhkiy qqlsatlera lqankhhiea qqrlllvtvf alsvhyqpvd
     1801 vslaistgll nvlsqlcgtd tmlgqplqll pktgvsqlst alkvastrll qilaittgty
     1861 adklspkvvq slldllcsql knllsqtgvl hmasfgegeq edgeeeekkv dssgetekkd
     1921 fraalrkqha aelhlgdflv flrrvvsska iqskmaspkw tevllniasq kcssgiplvg
     1981 nlrtrllalh vleavlpace sgveddqmaq iverlfslls dcmwetpiaq akhaiqikek
     2041 eqeiklqkqg eleeedenlp iqevsfdpek aqcclvengq ilthgsggkg yglastgvts
     2101 gcyqwkfyiv kenrgnegtc vgvsrwpvhd fnhrttsdmw lyraysgnly hngeqtltls
     2161 sftqgdfitc vldmeartis fgkngeepkl afedvdaael ypcvmfyssn pgekvkicdm
     2221 qmrgtprdll pgdpicspva avlaeatiql irilhrtdrw tycinkkmme rlhkikicik
     2281 esgqklkksr svqsreenem reekeskeee kgkhtrhgla dlselqlrtl cievwpvlav
     2341 iggvdaglrv ggrcvhkqtg rhatllgvvk egstsakvqw deaeitisfp tfwspsdtpl
     2401 ynlepceplp fdvarfrglt asvlldltyl tgvhedmgkq stkrhekkhr heseekgdve
     2461 qkpesesald mrtgltsddv ksqsttssks eneiasfsld ptlpsvesqh qitegkrknh
     2521 ehmsknhdva qseiravqls ylylgamksl sallgcskya elllipkvla enghnsdcas
     2581 spvvhedvem raalqflmrh mvkravmrsp ikralgladl eraqamiykl vvhglledqf
     2641 ggkikqeidq qaeesdpaqq aqtpvttsps assttsfmss sledtttatt pvtdtetvpa
     2701 sespgvmpls llrqmfssyp tttvlptrra qtppisslpt spsdevgrrq sltspdsqsa
     2761 rpanrtalsd pssrlstspp ppaiavplle mgfslrqiak ameatgarge adaqnitvla
     2821 mwmiehpghe deeepqsgst adsrpgaavl gsggksndpc ylqspgdips adaaemeegf
     2881 sespdnldht enaasgsgps argrsavtrr hkfdlaartl laraaglyrs vqahrnqsrr
     2941 egislqqdpg alydfnldee leidlddeam eamfgqdlts dndilgmwip evldwptwhv
     3001 cesedreevv vcelcecsvv sfnqhmkrnh pgcgrsanrq gyrsngsyvd gwfggecgsg
     3061 npyyllcgtc rekylamktk skstsseryk gqapdligkq dsvyedwdml dvdedekltg
     3121 eeefellagp lglndrrivp epvqfpdsdp lgasvamvta tnsmeetlmq igchgsveks
     3181 ssgritlgeq aaalanphdr vvalrrvtaa aqvllartmv mralsllsvs gsscslaagl
     3241 eslgltdirt lvrlmclaaa graglstsps amastsersr gghskankpi sclaylstav
     3301 gclasnapsa akllvqlctq nlisaatgvn lttvddsiqr kflpsflrgi aeenklvtsp
     3361 nfvvtqalva lladkgaklr pnydksevek kgplelanal aacclssrls sqhrqwaaqq
     3421 lvrtlaahdr dnqttlqtla dmggdlrkcs fikleahqnr vmtcvwcnkk gllatsgndg
     3481 tirvwnvtkk qyslqqtcvf nrlegdaees lgspsdpsfs pvswsisgky lagalekmvn
     3541 iwqvnggkgl vdiqphwvsa lawpeegpat awsgespell lvgrmdgslg lievvdvstm
     3601 hrrelehcyr kdvsvtciaw fsedrpfavg yfdgklllgt keplekggiv lidahkdtli
     3661 smkwdptghi lmtcakedsv klwgsisgcw cclhslchps ivngiawcrl pgkgsklqll
     3721 matgcqsglv cvwripqdtt qtnvtsaegw weqesncqdg yrkssgakcv yqlrghitpv
     3781 rtvafssdgl alvsgglggl mniwslrdgs vlqtvvigsg aiqttvwipe vgvaacsnrs
     3841 kdvlvvncta ewaaanhvla tcrtalkqqg vlglnmapcm raflerlpmm lqeqyayekp
     3901 hvvcgdqlvh spymqclasl avglhldqll cnppvpphhq nclpdpaswn pnewawlecf
     3961 sttikaaeal tngaqfpesf tvpdlepvpe delvflmdns kwingmdeqi mswatsrped
     4021 whlggkcdvy lwgagrhgql aeagrnvmvp aaapsfsqaq qvicgqnctf viqangtvla
     4081 cgegsygrlg qgnsddlhvl tvisalqgfv vtqlvtscgs dghsmaltes gevfswgdgd
     4141 ygklghgnsd rqrrprqiea lqgeevvqms cgfkhsavvt sdgklftfgn gdygrlglgn
     4201 tsnkklperv talegyqigq vacglnhtla vsadgsmvwa fgdgdygklg lgnstakssp
     4261 qkidvlcgig ikkvacgtqf svaltkdghv ytfgqdrlig lpegrarnhn rpqqipvlag
     4321 viiedvavga ehtlalasng dvyawgsnse gqlglghtnh vreptlvtgl qgknvrqisa
     4381 grchsaawta ppvpprapgv svplqlglpd tvppqygalr evsihtvrar lrllyhfsdl
     4441 mysswrllnl spnnqnstsh ynagtwgivq gqlrpllapr vytlpmvrsi gktmvqgkny
     4501 gpqitvkris trgrkckpif vqiarqvvkl nasdlrlpsr awkvklvgeg addaggvfdd
     4561 titemcqele tgivdllips pnataevgyn rdrflfnpsa cldehlmqfk flgilmgvai
     4621 rtkkpldlhl aplvwkqlcc vpltledlee vdllyvqtln silhiedsgi teesfhemip
     4681 ldsfvgqsad gkmvpiipgg nsipltfsnr keyveraiey rlhemdrqva avregmswiv
     4741 pvpllsllta kqleqmvcgm peisvevlkk vvryrevdeq hqlvqwfwht leefsneerv
     4801 lfmrfvsgrs rlpantadis qrfqimkvdr pydslptsqt cffqlrlppy ssqlvmaerl
     4861 ryainncrsi dmdnymlsrn vdnaegsdtd y
//
LOCUS       XP_047289178            4891 aa            linear   PRI 05-AUG-2025
DEFINITION  putative E3 ubiquitin-protein ligase HERC1 isoform X11 [Homo
            sapiens].
ACCESSION   XP_047289178
VERSION     XP_047289178.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433222.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4891
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4891
                     /product="putative E3 ubiquitin-protein ligase HERC1
                     isoform X11"
                     /calculated_mol_wt=535359
     Region          374..703
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          683..733
                     /region_name="RCC1"
                     /note="Regulator of chromosome condensation (RCC1) repeat;
                     pfam00415"
                     /db_xref="CDD:395335"
     Region          2040..2197
                     /region_name="SPRY_HERC1"
                     /note="SPRY domain in HERC1; cd12881"
                     /db_xref="CDD:293939"
     Region          2761..2804
                     /region_name="UBA_HERC1"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC1 and similar proteins; cd14401"
                     /db_xref="CDD:270584"
     Region          <3417..3808
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          3462..3505
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3519..3554
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3559..3606
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3615..3650
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3659..3695
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3702..3733
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3780..3816
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          4029..4365
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          4503..4871
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4508,4549,4560,4627,4805,4835..4836,4839..4843,4863,
                     4870)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4655,4658..4659,4661..4662,4665,4673,4675,
                     4679..4680,4682,4691,4696,4713,4717)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4891
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /coded_by="XM_047433222.1:154..14829"
                     /db_xref="GeneID:8925"
                     /db_xref="HGNC:HGNC:4867"
                     /db_xref="MIM:605109"
ORIGIN      
        1 matmippvkl kwlehlnssw itedsesiat regvavlysk lvsnkevvpl pqqvlclkgp
       61 qlpdferesl ssdeqdhyld allssqlala kmvcsdspfa galrkrllvl qrvfyalsnk
      121 yhdkgkvkqq qhspesssgs advhsvserp rsstdaliem gvrtglsllf allrqswmmp
      181 vsgpglslcn dvihtaievv sslpplslan eskippmgld clsqvttflk gvtipnsgad
      241 tlgrrlasel llglaaqrgs lryllewiem algasavvht mekgkllssq egmisfdcfm
      301 tilmqmrrsl gssadrsqwr eptrtsdglc slyeaalclf eevcrmasdy srtcaspdsi
      361 qtgdapivse tcevyvwgsn sshqlvegtq ekilqpklap sfsdaqtiea gqyctfvist
      421 dgsvracgkg sygrlglgds nnqstlkklt fephrsikkv ssskgsdght lafttegevf
      481 swgdgdygkl ghgnsstqky pkliqgplqg kvvvcvsagy rhsaavtedg elytwgegdf
      541 grlghgdsns rniptlvkdi snvgevscgs shtialskdg rtvwsfgggd ngklghgdtn
      601 rvykpkviea lqgmfirkvc agsqsslalt stgqvyawgc gaclgcgsse atalrpklie
      661 elaatrivdv sigdshclal shdnevyawg nnsmgqcgqg nstgpitkpk kvsgldgiai
      721 qqisagtshs lawtalprdr qvvawhrpyc vdleestfsh lrsflerycd kinseipplp
      781 fpssrehhsf lklclkllsn hlalalaggv atsilgrqag plrnllfrlm dstvpdeiqe
      841 vvietlsvga tmllpplrer mellhsllpq gpdrweslsk gqrmqldiil tslqdhthva
      901 sllgysspsd aadlssvctg ygnlsdqpyg tqschpdthl aeilmktllr nlgfytdqaf
      961 geleknsdkf llgtsssens qpahlhellc slqkqllafc hinnisenss svallhkhlq
     1021 lllphatdiy srsanllkes pwngsvgekl rdviyvsaag smlcqivnsl lllpvsvarp
     1081 llsylldllp pldclnrllp aadlledqel qwplhggpel idpaglplpq paqswvwlvd
     1141 lertiallig rclggmlqgs pvspeeqdta ywmktplfsd gvemdtpqld kcmsclleva
     1201 lsgneeqkpf dyklrpeiav yvdlalgcsk eparslwism qdyavskdwd satlsnesll
     1261 dtvsrfvlaa llkhtnllsq acgesryqpg khlsevyrcv ykvrsrllac knleliqtrs
     1321 ssrdrwisen qdsadvdpqe hsftrtidee aemeeqaerd reeghpeped eeeerehevm
     1381 tagnlvfvlh vteifqcfls arevarsrdr drmnsgagsg araddpppqs qqerrvstdl
     1441 pegqdvytaa cnsvihrcal lilgvspvid elqkrreegq lqqpstsase ggglmtrses
     1501 ltaesrlvht spnyrliksr sesdlsqpes deegyalsgr rnvdldlaas hrkrgpmhsq
     1561 leslsdswar lkhsrdwlcn ssysfesdfd ltkslgvhtl ienvvsfvsg dvgnapgfke
     1621 peesmstspq asiiameqqq lraelrleal hqilvllsgm eekgsislag srlssgfqss
     1681 tlltsvrlqf lagcfglgtv ghtggkgesg rlhhyqdgir aakrniqiei qvavhkiyqq
     1741 lsatleralq ankhhieaqq rlllvtvfal svhyqpvdvs laistgllnv lsqlcgtdtm
     1801 lgqplqllpk tgvsqlstal kvastrllqi laittgtyad klspkvvqsl ldllcsqlkn
     1861 llsqtgvlhm asfgegeqed geeeekkvds sgetekkdfr aalrkqhaae lhlgdflvfl
     1921 rrvvsskaiq skmaspkwte vllniasqkc ssgiplvgnl rtrllalhvl eavlpacesg
     1981 veddqmaqiv erlfsllsdc mwetpiaqak haiqikekeq eiklqqgele eedenlpiqe
     2041 vsfdpekaqc clvengqilt hgsggkgygl astgvtsgcy qwkfyivken rgnegtcvgv
     2101 srwpvhdfnh rttsdmwlyr aysgnlyhng eqtltlssft qgdfitcvld meartisfgk
     2161 ngeepklafe dvdaaelypc vmfyssnpge kvkicdmqmr gtprdllpgd picspvaavl
     2221 aeatiqliri lhrtdrwtyc inkkmmerlh kikicikesg qklkksrsvq sreenemree
     2281 keskeeekgk htrhgladls elqlrtlcie vwpvlavigg vdaglrvggr cvhkqtgrha
     2341 tllgvvkegs tsakvqwdea eitisfptfw spsdtplynl epceplpfdv arfrgltasv
     2401 lldltyltgv hedmgkqstk rhekkhrhes eekgdveqkp esesaldmrt gltsddvksq
     2461 sttssksene iasfsldptl psvesqhqit egkrknhehm sknhdvaqse iravqlsyly
     2521 lgamkslsal lgcskyaell lipkvlaeng hnsdcasspv vhedvemraa lqflmrhmvk
     2581 ravmrspikr algladlera qamiyklvvh glledqfggk ikqeidqqae esdpaqqaqt
     2641 pvttspsass ttsfmsssle dtttattpvt dtetvpases pgvmplsllr qmfssypttt
     2701 vlptrraqtp pisslptsps devgrrqslt spdsqsarpa nrtalsdpss rlstsppppa
     2761 iavpllemgf slrqiakame atgargeada qnitvlamwm iehpghedee epqsgstads
     2821 rpgaavlgsg gksndpcylq spgdipsada aemeegfses pdnldhtena asgsgpsarg
     2881 rsavtrrhkf dlaartllar aaglyrsvqa hrnqsrregi slqqdpgaly dfnldeelei
     2941 dlddeameam fgqdltsdnd ilgmwipevl dwptwhvces edreevvvce lcecsvvsfn
     3001 qhmkrnhpgc grsanrqgyr sngsyvdgwf ggecgsgnpy yllcgtcrek ylamktksks
     3061 tsserykgqa pdligkqdsv yeedwdmldv dedekltgee efellagplg lndrrivpep
     3121 vqfpdsdplg asvamvtatn smeetlmqie lcfsgchgsv eksssgritl geqaaalanp
     3181 hdrvvalrrv taaaqvllar tmvmralsll svsgsscsla agleslgltd irtlvrlmcl
     3241 aaagraglst spsamastse rsrgghskan kpisclayls tavgclasna psaakllvql
     3301 ctqnlisaat gvnlttvdds iqrkflpsfl rgiaeenklv tspnfvvtqa lvalladkga
     3361 klrpnydkse vekkgliaql yahpsydpsa vgplelanal aacclssrls sqhrqwaaqq
     3421 lvrtlaahdr dnqttlqtla dmggdlrkcs fikleahqnr vmtcvwcnkk gllatsgndg
     3481 tirvwnvtkk qyslqqtcvf nrlegdaees lgspsdpsfs pvswsisgky lagalekmvn
     3541 iwqvnggkgl vdiqphwvsa lawpeegpat awsgespell lvgrmdgslg lievvdvstm
     3601 hrrelehcyr kdvsvtciaw fsedrpfavg yfdgklllgt keplekggiv lidahkdtli
     3661 smkwdptghi lmtcakedsv klwgsisgcw cclhslchps ivngiawcrl pgkgsklqll
     3721 matgcqsglv cvwripqdtt qtnvtsaegw weqesncqdg yrkssgakcv yqlrghitpv
     3781 rtvafssdgl alvsgglggl mniwslrdgs vlqtvvigsg aiqttvwipe vgvaacsnrs
     3841 kdvlvvncta ewaaanhvla tcrtalkqqg vlglnmapcm raflerlpmm lqeqyayekp
     3901 hvvcgdqlvh spymqclasl avglhldqll cnppvpphhq nclpdpaswn pnewawlecf
     3961 sttikaaeal tngaqfpesf tvpdlepvpe delvflmdns kwingmdeqi mswatsrped
     4021 whlggkcdvy lwgagrhgql aeagrnvmvp aaapsfsqaq qvicgqnctf viqangtvla
     4081 cgegsygrlg qgnsddlhvl tvisalqgfv vtqlvtscgs dghsmaltes gevfswgdgd
     4141 ygklghgnsd rqrrprqiea lqgeevvqms cgfkhsavvt sdgklftfgn gdygrlglgn
     4201 tsnkklperv talegyqigq vacglnhtla vsadgsmvwa fgdgdygklg lgnstakssp
     4261 qkidvlcgig ikkvacgtqf svaltkdghv ytfgqdrlig lpegrarnhn rpqqipvlag
     4321 viiedvavga ehtlalasng dvyawgsnse gqlglghtnh vreptlvtgl qgknvrqisa
     4381 grchsaawta ppvpprapgv svplqlglpd tvppqygalr evsihtvrar lrllyhfsdl
     4441 mysswrllnl spnnqnstsh ynagtwgivq gqlrpllapr vytlpmvrsi gktmvqgkny
     4501 gpqitvkris trgrkckpif vqiarqvvkl nasdlrlpsr awkvklvgeg addaggvfdd
     4561 titemcqele tgivdllips pnataevgyn rdrflfnpsa cldehlmqfk flgilmgvai
     4621 rtkkpldlhl aplvwkqlcc vpltledlee vdllyvqtln silhiedsgi teesfhemip
     4681 ldsfvgqsad gkmvpiipgg nsipltfsnr keyveraiey rlhemdrqva avregmswiv
     4741 pvpllsllta kqleqmvcgm peisvevlkk vvryrevdeq hqlvqwfwht leefsneerv
     4801 lfmrfvsgrs rlpantadis qrfqimkvdr pydslptsqt cffqlrlppy ssqlvmaerl
     4861 ryainncrsi dmdnymlsrn vdnaegsdtd y
//
LOCUS       XP_047289179            4885 aa            linear   PRI 05-AUG-2025
DEFINITION  putative E3 ubiquitin-protein ligase HERC1 isoform X12 [Homo
            sapiens].
ACCESSION   XP_047289179
VERSION     XP_047289179.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433223.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4885
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4885
                     /product="putative E3 ubiquitin-protein ligase HERC1
                     isoform X12"
                     /calculated_mol_wt=534840
     Region          374..703
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          683..733
                     /region_name="RCC1"
                     /note="Regulator of chromosome condensation (RCC1) repeat;
                     pfam00415"
                     /db_xref="CDD:395335"
     Region          2063..2220
                     /region_name="SPRY_HERC1"
                     /note="SPRY domain in HERC1; cd12881"
                     /db_xref="CDD:293939"
     Region          2784..2827
                     /region_name="UBA_HERC1"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC1 and similar proteins; cd14401"
                     /db_xref="CDD:270584"
     Region          <3411..3802
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          3456..3499
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3513..3548
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3553..3600
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3609..3644
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3653..3689
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3696..3727
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3774..3810
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          4023..4359
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          4497..4865
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4502,4543,4554,4621,4799,4829..4830,4833..4837,4857,
                     4864)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4649,4652..4653,4655..4656,4659,4667,4669,
                     4673..4674,4676,4685,4690,4707,4711)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4885
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /coded_by="XM_047433223.1:154..14811"
                     /db_xref="GeneID:8925"
                     /db_xref="HGNC:HGNC:4867"
                     /db_xref="MIM:605109"
ORIGIN      
        1 matmippvkl kwlehlnssw itedsesiat regvavlysk lvsnkevvpl pqqvlclkgp
       61 qlpdferesl ssdeqdhyld allssqlala kmvcsdspfa galrkrllvl qrvfyalsnk
      121 yhdkgkvkqq qhspesssgs advhsvserp rsstdaliem gvrtglsllf allrqswmmp
      181 vsgpglslcn dvihtaievv sslpplslan eskippmgld clsqvttflk gvtipnsgad
      241 tlgrrlasel llglaaqrgs lryllewiem algasavvht mekgkllssq egmisfdcfm
      301 tilmqmrrsl gssadrsqwr eptrtsdglc slyeaalclf eevcrmasdy srtcaspdsi
      361 qtgdapivse tcevyvwgsn sshqlvegtq ekilqpklap sfsdaqtiea gqyctfvist
      421 dgsvracgkg sygrlglgds nnqstlkklt fephrsikkv ssskgsdght lafttegevf
      481 swgdgdygkl ghgnsstqky pkliqgplqg kvvvcvsagy rhsaavtedg elytwgegdf
      541 grlghgdsns rniptlvkdi snvgevscgs shtialskdg rtvwsfgggd ngklghgdtn
      601 rvykpkviea lqgmfirkvc agsqsslalt stgqvyawgc gaclgcgsse atalrpklie
      661 elaatrivdv sigdshclal shdnevyawg nnsmgqcgqg nstgpitkpk kvsgldgiai
      721 qqisagtshs lawtalprdr qvvawhrpyc vdleestfsh lrsflerycd kinseipplp
      781 fpssrehhsf lklclkllsn hlalalaggv atsilgrqag plrnllfrlm dstvpdeiqe
      841 vvietlsvga tmllpplrer mellhsllpq gpdrweslsk gqrmqldiil tslqdhthva
      901 sllgysspsd aadlssvctg ygnlsdqpyg tqschpdthl aeilmktllr nlgfytdqaf
      961 geleknsdkf llgtsssens qpahlhellc slqkqllafc hinnisenss svallhkhlq
     1021 lllphatdiy srsanllkes pwngsvgekl rdviyvsaag smlcqivnsl lllpvsvarp
     1081 llsylldllp pldclnrllp aadlledqel qwplhggpel idpaglplpq paqswvwlvd
     1141 lertiallig rclggmlqgs pvspeeqdta ywmktplfsd gvemdtpqld kcmsclleva
     1201 lsgneeqkpf dyklrpeiav yvdlalgcsk eparslwism qdyavskdwd satlsnesll
     1261 dtvsrfvlaa llkhtnllsq acgesryqpg khlsevyrcv ykvrsrllac knleliqtrs
     1321 ssrdrwisen qdsadvdpqe hsftrtidee aemeeqaerd reeghpeped eeeerehevm
     1381 tagnlvfvlh vteifqcfls arevarsrdr drmnsgagsg araddpppqs qqerrvstdl
     1441 pegqdvytaa cnsvihrcal lilgvspvid elqkrreegq lqqpstsase ggglmtrses
     1501 ltaesrlvht spnyrliksr sesdlsqpes deegyalsgr rnvdldlaas hrkrvylllf
     1561 gqlsprkkks fkqvhdgpmh sqleslsdsw arlkhsrdwl cnssysfesd fdltkslgvh
     1621 tlienvvsfv sgdvgnapgf kepeesmsts pqasiiameq qqlraelrle alhqilvlls
     1681 gmeekgsisl agsrlssgfq sstlltsvrl qflagcfglg tvghtggkge sgrlhhyqdg
     1741 iraakrniqi eiqvavhkiy qqlsatlera lqankhhiea qqrlllvtvf alsvhyqpvd
     1801 vslaistgll nvlsqlcgtd tmlgqplqll pktgvsqlst alkvastrll qilaittgty
     1861 adklspkvvq slldllcsql knllsqtgvl hmasfgegeq edgeeeekkv dssgetekkd
     1921 fraalrkqha aelhlgdflv flrrvvsska iqskmaspkw tevllniasq kcssgiplvg
     1981 nlrtrllalh vleavlpace sgveddqmaq iverlfslls dcmwetpiaq akhaiqikek
     2041 eqeiklqkqg eleeedenlp iqevsfdpek aqcclvengq ilthgsggkg yglastgvts
     2101 gcyqwkfyiv kenrgnegtc vgvsrwpvhd fnhrttsdmw lyraysgnly hngeqtltls
     2161 sftqgdfitc vldmeartis fgkngeepkl afedvdaael ypcvmfyssn pgekvkicdm
     2221 qmrgtprdll pgdpicspva avlaeatiql irilhrtdrw tycinkkmme rlhkikicik
     2281 esgqklkksr svqsreenem reekeskeee kgkhtrhgla dlselqlrtl cievwpvlav
     2341 iggvdaglrv ggrcvhkqtg rhatllgvvk egstsakvqw deaeitisfp tfwspsdtpl
     2401 ynlepceplp fdvarfrglt asvlldltyl tgvhedmgkq stkrhekkhr heseekgdve
     2461 qkpesesald mrtgltsddv ksqsttssks eneiasfsld ptlpsvesqh qitegkrknh
     2521 ehmsknhdva qseiravqls ylylgamksl sallgcskya elllipkvla enghnsdcas
     2581 spvvhedvem raalqflmrh mvkravmrsp ikralgladl eraqamiykl vvhglledqf
     2641 ggkikqeidq qaeesdpaqq aqtpvttsps assttsfmss sledtttatt pvtdtetvpa
     2701 sespgvmpls llrqmfssyp tttvlptrra qtppisslpt spsdevgrrq sltspdsqsa
     2761 rpanrtalsd pssrlstspp ppaiavplle mgfslrqiak ameatgarge adaqnitvla
     2821 mwmiehpghe deeepqsgst adsrpgaavl gsggksndpc ylqspgdips adaaemeegf
     2881 sespdnldht enaasgsgps argrsavtrr hkfdlaartl laraaglyrs vqahrnqsrr
     2941 egislqqdpg alydfnldee leidlddeam eamfgqdlts dndilgmwip ehvcesedre
     3001 evvvcelcec svvsfnqhmk rnhpgcgrsa nrqgyrsngs yvdgwfggec gsgnpyyllc
     3061 gtcrekylam ktkskstsse rykgqapdli gkqdsvyeed wdmldvdede kltgeeefel
     3121 lagplglndr rivpepvqfp dsdplgasva mvtatnsmee tlmqigchgs veksssgrit
     3181 lgeqaaalan phdrvvalrr vtaaaqvlla rtmvmralsl lsvsgsscsl aagleslglt
     3241 dirtlvrlmc laaagragls tspsamasts ersrgghska nkpisclayl stavgclasn
     3301 apsaakllvq lctqnlisaa tgvnlttvdd siqrkflpsf lrgiaeenkl vtspnfvvtq
     3361 alvalladkg aklrpnydks evekkgplel analaaccls srlssqhrqw aaqqlvrtla
     3421 ahdrdnqttl qtladmggdl rkcsfiklea hqnrvmtcvw cnkkgllats gndgtirvwn
     3481 vtkkqyslqq tcvfnrlegd aeeslgspsd psfspvswsi sgkylagale kmvniwqvng
     3541 gkglvdiqph wvsalawpee gpatawsges pelllvgrmd gslglievvd vstmhrrele
     3601 hcyrkdvsvt ciawfsedrp favgyfdgkl llgtkeplek ggivlidahk dtlismkwdp
     3661 tghilmtcak edsvklwgsi sgcwcclhsl chpsivngia wcrlpgkgsk lqllmatgcq
     3721 sglvcvwrip qdttqtnvts aegwweqesn cqdgyrkssg akcvyqlrgh itpvrtvafs
     3781 sdglalvsgg lgglmniwsl rdgsvlqtvv igsgaiqttv wipevgvaac snrskdvlvv
     3841 nctaewaaan hvlatcrtal kqqgvlglnm apcmrafler lpmmlqeqya yekphvvcgd
     3901 qlvhspymqc laslavglhl dqllcnppvp phhqnclpdp aswnpnewaw lecfsttika
     3961 aealtngaqf pesftvpdle pvpedelvfl mdnskwingm deqimswats rpedwhlggk
     4021 cdvylwgagr hgqlaeagrn vmvpaaapsf sqaqqvicgq nctfviqang tvlacgegsy
     4081 grlgqgnsdd lhvltvisal qgfvvtqlvt scgsdghsma ltesgevfsw gdgdygklgh
     4141 gnsdrqrrpr qiealqgeev vqmscgfkhs avvtsdgklf tfgngdygrl glgntsnkkl
     4201 pervtalegy qigqvacgln htlavsadgs mvwafgdgdy gklglgnsta ksspqkidvl
     4261 cgigikkvac gtqfsvaltk dghvytfgqd rliglpegra rnhnrpqqip vlagviiedv
     4321 avgaehtlal asngdvyawg snsegqlglg htnhvreptl vtglqgknvr qisagrchsa
     4381 awtappvppr apgvsvplql glpdtvppqy galrevsiht vrarlrllyh fsdlmysswr
     4441 llnlspnnqn stshynagtw givqgqlrpl laprvytlpm vrsigktmvq gknygpqitv
     4501 kristrgrkc kpifvqiarq vvklnasdlr lpsrawkvkl vgegaddagg vfddtitemc
     4561 qeletgivdl lipspnatae vgynrdrflf npsacldehl mqfkflgilm gvairtkkpl
     4621 dlhlaplvwk qlccvpltle dleevdllyv qtlnsilhie dsgiteesfh emipldsfvg
     4681 qsadgkmvpi ipggnsiplt fsnrkeyver aieyrlhemd rqvaavregm swivpvplls
     4741 lltakqleqm vcgmpeisve vlkkvvryre vdeqhqlvqw fwhtleefsn eervlfmrfv
     4801 sgrsrlpant adisqrfqim kvdrpydslp tsqtcffqlr lppyssqlvm aerlryainn
     4861 crsidmdnym lsrnvdnaeg sdtdy
//
LOCUS       XP_047289180            4884 aa            linear   PRI 05-AUG-2025
DEFINITION  putative E3 ubiquitin-protein ligase HERC1 isoform X13 [Homo
            sapiens].
ACCESSION   XP_047289180
VERSION     XP_047289180.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433224.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4884
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4884
                     /product="putative E3 ubiquitin-protein ligase HERC1
                     isoform X13"
                     /calculated_mol_wt=534788
     Region          374..703
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          683..733
                     /region_name="RCC1"
                     /note="Regulator of chromosome condensation (RCC1) repeat;
                     pfam00415"
                     /db_xref="CDD:395335"
     Region          2063..2220
                     /region_name="SPRY_HERC1"
                     /note="SPRY domain in HERC1; cd12881"
                     /db_xref="CDD:293939"
     Region          2776..2819
                     /region_name="UBA_HERC1"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC1 and similar proteins; cd14401"
                     /db_xref="CDD:270584"
     Region          <3410..3801
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          3455..3498
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3512..3547
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3552..3599
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3608..3643
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3652..3688
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3695..3726
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3773..3809
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          4022..4358
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          4496..4864
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4501,4542,4553,4620,4798,4828..4829,4832..4836,4856,
                     4863)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4648,4651..4652,4654..4655,4658,4666,4668,
                     4672..4673,4675,4684,4689,4706,4710)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4884
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /coded_by="XM_047433224.1:154..14808"
                     /db_xref="GeneID:8925"
                     /db_xref="HGNC:HGNC:4867"
                     /db_xref="MIM:605109"
ORIGIN      
        1 matmippvkl kwlehlnssw itedsesiat regvavlysk lvsnkevvpl pqqvlclkgp
       61 qlpdferesl ssdeqdhyld allssqlala kmvcsdspfa galrkrllvl qrvfyalsnk
      121 yhdkgkvkqq qhspesssgs advhsvserp rsstdaliem gvrtglsllf allrqswmmp
      181 vsgpglslcn dvihtaievv sslpplslan eskippmgld clsqvttflk gvtipnsgad
      241 tlgrrlasel llglaaqrgs lryllewiem algasavvht mekgkllssq egmisfdcfm
      301 tilmqmrrsl gssadrsqwr eptrtsdglc slyeaalclf eevcrmasdy srtcaspdsi
      361 qtgdapivse tcevyvwgsn sshqlvegtq ekilqpklap sfsdaqtiea gqyctfvist
      421 dgsvracgkg sygrlglgds nnqstlkklt fephrsikkv ssskgsdght lafttegevf
      481 swgdgdygkl ghgnsstqky pkliqgplqg kvvvcvsagy rhsaavtedg elytwgegdf
      541 grlghgdsns rniptlvkdi snvgevscgs shtialskdg rtvwsfgggd ngklghgdtn
      601 rvykpkviea lqgmfirkvc agsqsslalt stgqvyawgc gaclgcgsse atalrpklie
      661 elaatrivdv sigdshclal shdnevyawg nnsmgqcgqg nstgpitkpk kvsgldgiai
      721 qqisagtshs lawtalprdr qvvawhrpyc vdleestfsh lrsflerycd kinseipplp
      781 fpssrehhsf lklclkllsn hlalalaggv atsilgrqag plrnllfrlm dstvpdeiqe
      841 vvietlsvga tmllpplrer mellhsllpq gpdrweslsk gqrmqldiil tslqdhthva
      901 sllgysspsd aadlssvctg ygnlsdqpyg tqschpdthl aeilmktllr nlgfytdqaf
      961 geleknsdkf llgtsssens qpahlhellc slqkqllafc hinnisenss svallhkhlq
     1021 lllphatdiy srsanllkes pwngsvgekl rdviyvsaag smlcqivnsl lllpvsvarp
     1081 llsylldllp pldclnrllp aadlledqel qwplhggpel idpaglplpq paqswvwlvd
     1141 lertiallig rclggmlqgs pvspeeqdta ywmktplfsd gvemdtpqld kcmsclleva
     1201 lsgneeqkpf dyklrpeiav yvdlalgcsk eparslwism qdyavskdwd satlsnesll
     1261 dtvsrfvlaa llkhtnllsq acgesryqpg khlsevyrcv ykvrsrllac knleliqtrs
     1321 ssrdrwisen qdsadvdpqe hsftrtidee aemeeqaerd reeghpeped eeeerehevm
     1381 tagnlvfvlh vteifqcfls arevarsrdr drmnsgagsg araddpppqs qqerrvstdl
     1441 pegqdvytaa cnsvihrcal lilgvspvid elqkrreegq lqqpstsase ggglmtrses
     1501 ltaesrlvht spnyrliksr sesdlsqpes deegyalsgr rnvdldlaas hrkrvylllf
     1561 gqlsprkkks fkqvhdgpmh sqleslsdsw arlkhsrdwl cnssysfesd fdltkslgvh
     1621 tlienvvsfv sgdvgnapgf kepeesmsts pqasiiameq qqlraelrle alhqilvlls
     1681 gmeekgsisl agsrlssgfq sstlltsvrl qflagcfglg tvghtggkge sgrlhhyqdg
     1741 iraakrniqi eiqvavhkiy qqlsatlera lqankhhiea qqrlllvtvf alsvhyqpvd
     1801 vslaistgll nvlsqlcgtd tmlgqplqll pktgvsqlst alkvastrll qilaittgty
     1861 adklspkvvq slldllcsql knllsqtgvl hmasfgegeq edgeeeekkv dssgetekkd
     1921 fraalrkqha aelhlgdflv flrrvvsska iqskmaspkw tevllniasq kcssgiplvg
     1981 nlrtrllalh vleavlpace sgveddqmaq iverlfslls dcmwetpiaq akhaiqikek
     2041 eqeiklqkqg eleeedenlp iqevsfdpek aqcclvengq ilthgsggkg yglastgvts
     2101 gcyqwkfyiv kenrgnegtc vgvsrwpvhd fnhrttsdmw lyraysgnly hngeqtltls
     2161 sftqgdfitc vldmeartis fgkngeepkl afedvdaael ypcvmfyssn pgekvkicdm
     2221 qmrgtprdll pgdpicspva avlaeatiql irilhrtdrw tycinkkmme rlhkikicik
     2281 esgqklkksr svqsreenem reekeskeee kgkhtrhgla dlselqlrtl cievwpvlav
     2341 iggvdaglrv ggrcvhkqtg rhatllgvvk egstsakvqw deaeitisdt plynlepcep
     2401 lpfdvarfrg ltasvlldlt yltgvhedmg kqstkrhekk hrheseekgd veqkpesesa
     2461 ldmrtgltsd dvksqsttss kseneiasfs ldptlpsves qhqitegkrk nhehmsknhd
     2521 vaqseiravq lsylylgamk slsallgcsk yaelllipkv laenghnsdc asspvvhedv
     2581 emraalqflm rhmvkravmr spikralgla dleraqamiy klvvhglled qfggkikqei
     2641 dqqaeesdpa qqaqtpvtts psassttsfm sssledttta ttpvtdtetv pasespgvmp
     2701 lsllrqmfss yptttvlptr raqtppissl ptspsdevgr rqsltspdsq sarpanrtal
     2761 sdpssrlsts ppppaiavpl lemgfslrqi akameatgar geadaqnitv lamwmiehpg
     2821 hedeeepqsg stadsrpgaa vlgsggksnd pcylqspgdi psadaaemee gfsespdnld
     2881 htenaasgsg psargrsavt rrhkfdlaar tllaraagly rsvqahrnqs rregislqqd
     2941 pgalydfnld eeleidldde ameamfgqdl tsdndilgmw ipevldwptw hvcesedree
     3001 vvvcelcecs vvsfnqhmkr nhpgcgrsan rqgyrsngsy vdgwfggecg sgnpyyllcg
     3061 tcrekylamk tkskstsser ykgqapdlig kqdsvyeedw dmldvdedek ltgeeefell
     3121 agplglndrr ivpepvqfpd sdplgasvam vtatnsmeet lmqigchgsv eksssgritl
     3181 geqaaalanp hdrvvalrrv taaaqvllar tmvmralsll svsgsscsla agleslgltd
     3241 irtlvrlmcl aaagraglst spsamastse rsrgghskan kpisclayls tavgclasna
     3301 psaakllvql ctqnlisaat gvnlttvdds iqrkflpsfl rgiaeenklv tspnfvvtqa
     3361 lvalladkga klrpnydkse vekkgplela nalaacclss rlssqhrqwa aqqlvrtlaa
     3421 hdrdnqttlq tladmggdlr kcsfikleah qnrvmtcvwc nkkgllatsg ndgtirvwnv
     3481 tkkqyslqqt cvfnrlegda eeslgspsdp sfspvswsis gkylagalek mvniwqvngg
     3541 kglvdiqphw vsalawpeeg patawsgesp elllvgrmdg slglievvdv stmhrreleh
     3601 cyrkdvsvtc iawfsedrpf avgyfdgkll lgtkeplekg givlidahkd tlismkwdpt
     3661 ghilmtcake dsvklwgsis gcwcclhslc hpsivngiaw crlpgkgskl qllmatgcqs
     3721 glvcvwripq dttqtnvtsa egwweqesnc qdgyrkssga kcvyqlrghi tpvrtvafss
     3781 dglalvsggl gglmniwslr dgsvlqtvvi gsgaiqttvw ipevgvaacs nrskdvlvvn
     3841 ctaewaaanh vlatcrtalk qqgvlglnma pcmraflerl pmmlqeqyay ekphvvcgdq
     3901 lvhspymqcl aslavglhld qllcnppvpp hhqnclpdpa swnpnewawl ecfsttikaa
     3961 ealtngaqfp esftvpdlep vpedelvflm dnskwingmd eqimswatsr pedwhlggkc
     4021 dvylwgagrh gqlaeagrnv mvpaaapsfs qaqqvicgqn ctfviqangt vlacgegsyg
     4081 rlgqgnsddl hvltvisalq gfvvtqlvts cgsdghsmal tesgevfswg dgdygklghg
     4141 nsdrqrrprq iealqgeevv qmscgfkhsa vvtsdgklft fgngdygrlg lgntsnkklp
     4201 ervtalegyq igqvacglnh tlavsadgsm vwafgdgdyg klglgnstak sspqkidvlc
     4261 gigikkvacg tqfsvaltkd ghvytfgqdr liglpegrar nhnrpqqipv lagviiedva
     4321 vgaehtlala sngdvyawgs nsegqlglgh tnhvreptlv tglqgknvrq isagrchsaa
     4381 wtappvppra pgvsvplqlg lpdtvppqyg alrevsihtv rarlrllyhf sdlmysswrl
     4441 lnlspnnqns tshynagtwg ivqgqlrpll aprvytlpmv rsigktmvqg knygpqitvk
     4501 ristrgrkck pifvqiarqv vklnasdlrl psrawkvklv gegaddaggv fddtitemcq
     4561 eletgivdll ipspnataev gynrdrflfn psacldehlm qfkflgilmg vairtkkpld
     4621 lhlaplvwkq lccvpltled leevdllyvq tlnsilhied sgiteesfhe mipldsfvgq
     4681 sadgkmvpii pggnsipltf snrkeyvera ieyrlhemdr qvaavregms wivpvpllsl
     4741 ltakqleqmv cgmpeisvev lkkvvryrev deqhqlvqwf whtleefsne ervlfmrfvs
     4801 grsrlpanta disqrfqimk vdrpydslpt sqtcffqlrl ppyssqlvma erlryainnc
     4861 rsidmdnyml srnvdnaegs dtdy
//
LOCUS       XP_047289181            4884 aa            linear   PRI 05-AUG-2025
DEFINITION  putative E3 ubiquitin-protein ligase HERC1 isoform X14 [Homo
            sapiens].
ACCESSION   XP_047289181
VERSION     XP_047289181.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433225.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4884
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4884
                     /product="putative E3 ubiquitin-protein ligase HERC1
                     isoform X14"
                     /calculated_mol_wt=534711
     Region          374..703
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          683..733
                     /region_name="RCC1"
                     /note="Regulator of chromosome condensation (RCC1) repeat;
                     pfam00415"
                     /db_xref="CDD:395335"
     Region          2063..2220
                     /region_name="SPRY_HERC1"
                     /note="SPRY domain in HERC1; cd12881"
                     /db_xref="CDD:293939"
     Region          2784..2827
                     /region_name="UBA_HERC1"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC1 and similar proteins; cd14401"
                     /db_xref="CDD:270584"
     Region          <3410..3801
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          3455..3498
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3512..3547
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3552..3599
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3608..3643
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3652..3688
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3695..3726
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3773..3809
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          4022..4358
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          4496..4864
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4501,4542,4553,4620,4798,4828..4829,4832..4836,4856,
                     4863)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4648,4651..4652,4654..4655,4658,4666,4668,
                     4672..4673,4675,4684,4689,4706,4710)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4884
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /coded_by="XM_047433225.1:154..14808"
                     /db_xref="GeneID:8925"
                     /db_xref="HGNC:HGNC:4867"
                     /db_xref="MIM:605109"
ORIGIN      
        1 matmippvkl kwlehlnssw itedsesiat regvavlysk lvsnkevvpl pqqvlclkgp
       61 qlpdferesl ssdeqdhyld allssqlala kmvcsdspfa galrkrllvl qrvfyalsnk
      121 yhdkgkvkqq qhspesssgs advhsvserp rsstdaliem gvrtglsllf allrqswmmp
      181 vsgpglslcn dvihtaievv sslpplslan eskippmgld clsqvttflk gvtipnsgad
      241 tlgrrlasel llglaaqrgs lryllewiem algasavvht mekgkllssq egmisfdcfm
      301 tilmqmrrsl gssadrsqwr eptrtsdglc slyeaalclf eevcrmasdy srtcaspdsi
      361 qtgdapivse tcevyvwgsn sshqlvegtq ekilqpklap sfsdaqtiea gqyctfvist
      421 dgsvracgkg sygrlglgds nnqstlkklt fephrsikkv ssskgsdght lafttegevf
      481 swgdgdygkl ghgnsstqky pkliqgplqg kvvvcvsagy rhsaavtedg elytwgegdf
      541 grlghgdsns rniptlvkdi snvgevscgs shtialskdg rtvwsfgggd ngklghgdtn
      601 rvykpkviea lqgmfirkvc agsqsslalt stgqvyawgc gaclgcgsse atalrpklie
      661 elaatrivdv sigdshclal shdnevyawg nnsmgqcgqg nstgpitkpk kvsgldgiai
      721 qqisagtshs lawtalprdr qvvawhrpyc vdleestfsh lrsflerycd kinseipplp
      781 fpssrehhsf lklclkllsn hlalalaggv atsilgrqag plrnllfrlm dstvpdeiqe
      841 vvietlsvga tmllpplrer mellhsllpq gpdrweslsk gqrmqldiil tslqdhthva
      901 sllgysspsd aadlssvctg ygnlsdqpyg tqschpdthl aeilmktllr nlgfytdqaf
      961 geleknsdkf llgtsssens qpahlhellc slqkqllafc hinnisenss svallhkhlq
     1021 lllphatdiy srsanllkes pwngsvgekl rdviyvsaag smlcqivnsl lllpvsvarp
     1081 llsylldllp pldclnrllp aadlledqel qwplhggpel idpaglplpq paqswvwlvd
     1141 lertiallig rclggmlqgs pvspeeqdta ywmktplfsd gvemdtpqld kcmsclleva
     1201 lsgneeqkpf dyklrpeiav yvdlalgcsk eparslwism qdyavskdwd satlsnesll
     1261 dtvsrfvlaa llkhtnllsq acgesryqpg khlsevyrcv ykvrsrllac knleliqtrs
     1321 ssrdrwisen qdsadvdpqe hsftrtidee aemeeqaerd reeghpeped eeeerehevm
     1381 tagnlvfvlh vteifqcfls arevarsrdr drmnsgagsg araddpppqs qqerrvstdl
     1441 pegqdvytaa cnsvihrcal lilgvspvid elqkrreegq lqqpstsase ggglmtrses
     1501 ltaesrlvht spnyrliksr sesdlsqpes deegyalsgr rnvdldlaas hrkrvylllf
     1561 gqlsprkkks fkqvhdgpmh sqleslsdsw arlkhsrdwl cnssysfesd fdltkslgvh
     1621 tlienvvsfv sgdvgnapgf kepeesmsts pqasiiameq qqlraelrle alhqilvlls
     1681 gmeekgsisl agsrlssgfq sstlltsvrl qflagcfglg tvghtggkge sgrlhhyqdg
     1741 iraakrniqi eiqvavhkiy qqlsatlera lqankhhiea qqrlllvtvf alsvhyqpvd
     1801 vslaistgll nvlsqlcgtd tmlgqplqll pktgvsqlst alkvastrll qilaittgty
     1861 adklspkvvq slldllcsql knllsqtgvl hmasfgegeq edgeeeekkv dssgetekkd
     1921 fraalrkqha aelhlgdflv flrrvvsska iqskmaspkw tevllniasq kcssgiplvg
     1981 nlrtrllalh vleavlpace sgveddqmaq iverlfslls dcmwetpiaq akhaiqikek
     2041 eqeiklqkqg eleeedenlp iqevsfdpek aqcclvengq ilthgsggkg yglastgvts
     2101 gcyqwkfyiv kenrgnegtc vgvsrwpvhd fnhrttsdmw lyraysgnly hngeqtltls
     2161 sftqgdfitc vldmeartis fgkngeepkl afedvdaael ypcvmfyssn pgekvkicdm
     2221 qmrgtprdll pgdpicspva avlaeatiql irilhrtdrw tycinkkmme rlhkikicik
     2281 esgqklkksr svqsreenem reekeskeee kgkhtrhgla dlselqlrtl cievwpvlav
     2341 iggvdaglrv ggrcvhkqtg rhatllgvvk egstsakvqw deaeitisfp tfwspsdtpl
     2401 ynlepceplp fdvarfrglt asvlldltyl tgvhedmgkq stkrhekkhr heseekgdve
     2461 qkpesesald mrtgltsddv ksqsttssks eneiasfsld ptlpsvesqh qitegkrknh
     2521 ehmsknhdva qseiravqls ylylgamksl sallgcskya elllipkvla enghnsdcas
     2581 spvvhedvem raalqflmrh mvkravmrsp ikralgladl eraqamiykl vvhglledqf
     2641 ggkikqeidq qaeesdpaqq aqtpvttsps assttsfmss sledtttatt pvtdtetvpa
     2701 sespgvmpls llrqmfssyp tttvlptrra qtppisslpt spsdevgrrq sltspdsqsa
     2761 rpanrtalsd pssrlstspp ppaiavplle mgfslrqiak ameatgarge adaqnitvla
     2821 mwmiehpghe deeepqsgst adsrpgaavl gsggksndpc ylqspgdips adaaemeegf
     2881 sespdnldht enaasgsgps argrsavtrr hkfdlaartl laraaglyrs vqahrnqsrr
     2941 egislqqdpg alydfnldee leidlddeam eamfgqdlts dndilgmwip ehvcesedre
     3001 evvvcelcec svvsfnqhmk rnhpgcgrsa nrqgyrsngs yvdgwfggec gsgnpyyllc
     3061 gtcrekylam ktkskstsse rykgqapdli gkqdsvyedw dmldvdedek ltgeeefell
     3121 agplglndrr ivpepvqfpd sdplgasvam vtatnsmeet lmqigchgsv eksssgritl
     3181 geqaaalanp hdrvvalrrv taaaqvllar tmvmralsll svsgsscsla agleslgltd
     3241 irtlvrlmcl aaagraglst spsamastse rsrgghskan kpisclayls tavgclasna
     3301 psaakllvql ctqnlisaat gvnlttvdds iqrkflpsfl rgiaeenklv tspnfvvtqa
     3361 lvalladkga klrpnydkse vekkgplela nalaacclss rlssqhrqwa aqqlvrtlaa
     3421 hdrdnqttlq tladmggdlr kcsfikleah qnrvmtcvwc nkkgllatsg ndgtirvwnv
     3481 tkkqyslqqt cvfnrlegda eeslgspsdp sfspvswsis gkylagalek mvniwqvngg
     3541 kglvdiqphw vsalawpeeg patawsgesp elllvgrmdg slglievvdv stmhrreleh
     3601 cyrkdvsvtc iawfsedrpf avgyfdgkll lgtkeplekg givlidahkd tlismkwdpt
     3661 ghilmtcake dsvklwgsis gcwcclhslc hpsivngiaw crlpgkgskl qllmatgcqs
     3721 glvcvwripq dttqtnvtsa egwweqesnc qdgyrkssga kcvyqlrghi tpvrtvafss
     3781 dglalvsggl gglmniwslr dgsvlqtvvi gsgaiqttvw ipevgvaacs nrskdvlvvn
     3841 ctaewaaanh vlatcrtalk qqgvlglnma pcmraflerl pmmlqeqyay ekphvvcgdq
     3901 lvhspymqcl aslavglhld qllcnppvpp hhqnclpdpa swnpnewawl ecfsttikaa
     3961 ealtngaqfp esftvpdlep vpedelvflm dnskwingmd eqimswatsr pedwhlggkc
     4021 dvylwgagrh gqlaeagrnv mvpaaapsfs qaqqvicgqn ctfviqangt vlacgegsyg
     4081 rlgqgnsddl hvltvisalq gfvvtqlvts cgsdghsmal tesgevfswg dgdygklghg
     4141 nsdrqrrprq iealqgeevv qmscgfkhsa vvtsdgklft fgngdygrlg lgntsnkklp
     4201 ervtalegyq igqvacglnh tlavsadgsm vwafgdgdyg klglgnstak sspqkidvlc
     4261 gigikkvacg tqfsvaltkd ghvytfgqdr liglpegrar nhnrpqqipv lagviiedva
     4321 vgaehtlala sngdvyawgs nsegqlglgh tnhvreptlv tglqgknvrq isagrchsaa
     4381 wtappvppra pgvsvplqlg lpdtvppqyg alrevsihtv rarlrllyhf sdlmysswrl
     4441 lnlspnnqns tshynagtwg ivqgqlrpll aprvytlpmv rsigktmvqg knygpqitvk
     4501 ristrgrkck pifvqiarqv vklnasdlrl psrawkvklv gegaddaggv fddtitemcq
     4561 eletgivdll ipspnataev gynrdrflfn psacldehlm qfkflgilmg vairtkkpld
     4621 lhlaplvwkq lccvpltled leevdllyvq tlnsilhied sgiteesfhe mipldsfvgq
     4681 sadgkmvpii pggnsipltf snrkeyvera ieyrlhemdr qvaavregms wivpvpllsl
     4741 ltakqleqmv cgmpeisvev lkkvvryrev deqhqlvqwf whtleefsne ervlfmrfvs
     4801 grsrlpanta disqrfqimk vdrpydslpt sqtcffqlrl ppyssqlvma erlryainnc
     4861 rsidmdnyml srnvdnaegs dtdy
//
LOCUS       XP_047289182            4884 aa            linear   PRI 05-AUG-2025
DEFINITION  putative E3 ubiquitin-protein ligase HERC1 isoform X15 [Homo
            sapiens].
ACCESSION   XP_047289182
VERSION     XP_047289182.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433226.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4884
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4884
                     /product="putative E3 ubiquitin-protein ligase HERC1
                     isoform X15"
                     /calculated_mol_wt=534537
     Region          374..703
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          683..733
                     /region_name="RCC1"
                     /note="Regulator of chromosome condensation (RCC1) repeat;
                     pfam00415"
                     /db_xref="CDD:395335"
     Region          2041..2198
                     /region_name="SPRY_HERC1"
                     /note="SPRY domain in HERC1; cd12881"
                     /db_xref="CDD:293939"
     Region          2754..2797
                     /region_name="UBA_HERC1"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC1 and similar proteins; cd14401"
                     /db_xref="CDD:270584"
     Region          <3410..3801
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          3455..3498
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3512..3547
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3552..3599
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3608..3643
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3652..3688
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3695..3726
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3773..3809
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          4022..4358
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          4496..4864
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4501,4542,4553,4620,4798,4828..4829,4832..4836,4856,
                     4863)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4648,4651..4652,4654..4655,4658,4666,4668,
                     4672..4673,4675,4684,4689,4706,4710)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4884
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /coded_by="XM_047433226.1:154..14808"
                     /db_xref="GeneID:8925"
                     /db_xref="HGNC:HGNC:4867"
                     /db_xref="MIM:605109"
ORIGIN      
        1 matmippvkl kwlehlnssw itedsesiat regvavlysk lvsnkevvpl pqqvlclkgp
       61 qlpdferesl ssdeqdhyld allssqlala kmvcsdspfa galrkrllvl qrvfyalsnk
      121 yhdkgkvkqq qhspesssgs advhsvserp rsstdaliem gvrtglsllf allrqswmmp
      181 vsgpglslcn dvihtaievv sslpplslan eskippmgld clsqvttflk gvtipnsgad
      241 tlgrrlasel llglaaqrgs lryllewiem algasavvht mekgkllssq egmisfdcfm
      301 tilmqmrrsl gssadrsqwr eptrtsdglc slyeaalclf eevcrmasdy srtcaspdsi
      361 qtgdapivse tcevyvwgsn sshqlvegtq ekilqpklap sfsdaqtiea gqyctfvist
      421 dgsvracgkg sygrlglgds nnqstlkklt fephrsikkv ssskgsdght lafttegevf
      481 swgdgdygkl ghgnsstqky pkliqgplqg kvvvcvsagy rhsaavtedg elytwgegdf
      541 grlghgdsns rniptlvkdi snvgevscgs shtialskdg rtvwsfgggd ngklghgdtn
      601 rvykpkviea lqgmfirkvc agsqsslalt stgqvyawgc gaclgcgsse atalrpklie
      661 elaatrivdv sigdshclal shdnevyawg nnsmgqcgqg nstgpitkpk kvsgldgiai
      721 qqisagtshs lawtalprdr qvvawhrpyc vdleestfsh lrsflerycd kinseipplp
      781 fpssrehhsf lklclkllsn hlalalaggv atsilgrqag plrnllfrlm dstvpdeiqe
      841 vvietlsvga tmllpplrer mellhsllpq gpdrweslsk gqrmqldiil tslqdhthva
      901 sllgysspsd aadlssvctg ygnlsdqpyg tqschpdthl aeilmktllr nlgfytdqaf
      961 geleknsdkf llgtsssens qpahlhellc slqkqllafc hinnisenss svallhkhlq
     1021 lllphatdiy srsanllkes pwngsvgekl rdviyvsaag smlcqivnsl lllpvsvarp
     1081 llsylldllp pldclnrllp aadlledqel qwplhggpel idpaglplpq paqswvwlvd
     1141 lertiallig rclggmlqgs pvspeeqdta ywmktplfsd gvemdtpqld kcmsclleva
     1201 lsgneeqkpf dyklrpeiav yvdlalgcsk eparslwism qdyavskdwd satlsnesll
     1261 dtvsrfvlaa llkhtnllsq acgesryqpg khlsevyrcv ykvrsrllac knleliqtrs
     1321 ssrdrwisen qdsadvdpqe hsftrtidee aemeeqaerd reeghpeped eeeerehevm
     1381 tagnlvfvlh vteifqcfls arevarsrdr drmnsgagsg araddpppqs qqerrvstdl
     1441 pegqdvytaa cnsvihrcal lilgvspvid elqkrreegq lqqpstsase ggglmtrses
     1501 ltaesrlvht spnyrliksr sesdlsqpes deegyalsgr rnvdldlaas hrkrgpmhsq
     1561 leslsdswar lkhsrdwlcn ssysfesdfd ltkslgvhtl ienvvsfvsg dvgnapgfke
     1621 peesmstspq asiiameqqq lraelrleal hqilvllsgm eekgsislag srlssgfqss
     1681 tlltsvrlqf lagcfglgtv ghtggkgesg rlhhyqdgir aakrniqiei qvavhkiyqq
     1741 lsatleralq ankhhieaqq rlllvtvfal svhyqpvdvs laistgllnv lsqlcgtdtm
     1801 lgqplqllpk tgvsqlstal kvastrllqi laittgtyad klspkvvqsl ldllcsqlkn
     1861 llsqtgvlhm asfgegeqed geeeekkvds sgetekkdfr aalrkqhaae lhlgdflvfl
     1921 rrvvsskaiq skmaspkwte vllniasqkc ssgiplvgnl rtrllalhvl eavlpacesg
     1981 veddqmaqiv erlfsllsdc mwetpiaqak haiqikekeq eiklqkqgel eeedenlpiq
     2041 evsfdpekaq cclvengqil thgsggkgyg lastgvtsgc yqwkfyivke nrgnegtcvg
     2101 vsrwpvhdfn hrttsdmwly raysgnlyhn geqtltlssf tqgdfitcvl dmeartisfg
     2161 kngeepklaf edvdaaelyp cvmfyssnpg ekvkicdmqm rgtprdllpg dpicspvaav
     2221 laeatiqlir ilhrtdrwty cinkkmmerl hkikicikes gqklkksrsv qsreenemre
     2281 ekeskeeekg khtrhgladl selqlrtlci evwpvlavig gvdaglrvgg rcvhkqtgrh
     2341 atllgvvkeg stsakvqwde aeitisdtpl ynlepceplp fdvarfrglt asvlldltyl
     2401 tgvhedmgkq stkrhekkhr heseekgdve qkpesesald mrtgltsddv ksqsttssks
     2461 eneiasfsld ptlpsvesqh qitegkrknh ehmsknhdva qseiravqls ylylgamksl
     2521 sallgcskya elllipkvla enghnsdcas spvvhedvem raalqflmrh mvkravmrsp
     2581 ikralgladl eraqamiykl vvhglledqf ggkikqeidq qaeesdpaqq aqtpvttsps
     2641 assttsfmss sledtttatt pvtdtetvpa sespgvmpls llrqmfssyp tttvlptrra
     2701 qtppisslpt spsdevgrrq sltspdsqsa rpanrtalsd pssrlstspp ppaiavplle
     2761 mgfslrqiak ameatgarge adaqnitvla mwmiehpghe deeepqsgst adsrpgaavl
     2821 gsggksndpc ylqspgdips adaaemeegf sespdnldht enaasgsgps argrsavtrr
     2881 hkfdlaartl laraaglyrs vqahrnqsrr egislqqdpg alydfnldee leidlddeam
     2941 eamfgqdlts dndilgmwip evldwptwhv cesedreevv vcelcecsvv sfnqhmkrnh
     3001 pgcgrsanrq gyrsngsyvd gwfggecgsg npyyllcgtc rekylamktk skstsseryk
     3061 gqapdligkq dsvyeedwdm ldvdedeklt geeefellag plglndrriv pepvqfpdsd
     3121 plgasvamvt atnsmeetlm qielcfsgch gsveksssgr itlgeqaaal anphdrvval
     3181 rrvtaaaqvl lartmvmral sllsvsgssc slaagleslg ltdirtlvrl mclaaagrag
     3241 lstspsamas tsersrgghs kankpiscla ylstavgcla snapsaakll vqlctqnlis
     3301 aatgvnlttv ddsiqrkflp sflrgiaeen klvtspnfvv tqalvallad kgaklrpnyd
     3361 ksevekkgli aqlyahpsyd psavgplela nalaacclss rlssqhrqwa aqqlvrtlaa
     3421 hdrdnqttlq tladmggdlr kcsfikleah qnrvmtcvwc nkkgllatsg ndgtirvwnv
     3481 tkkqyslqqt cvfnrlegda eeslgspsdp sfspvswsis gkylagalek mvniwqvngg
     3541 kglvdiqphw vsalawpeeg patawsgesp elllvgrmdg slglievvdv stmhrreleh
     3601 cyrkdvsvtc iawfsedrpf avgyfdgkll lgtkeplekg givlidahkd tlismkwdpt
     3661 ghilmtcake dsvklwgsis gcwcclhslc hpsivngiaw crlpgkgskl qllmatgcqs
     3721 glvcvwripq dttqtnvtsa egwweqesnc qdgyrkssga kcvyqlrghi tpvrtvafss
     3781 dglalvsggl gglmniwslr dgsvlqtvvi gsgaiqttvw ipevgvaacs nrskdvlvvn
     3841 ctaewaaanh vlatcrtalk qqgvlglnma pcmraflerl pmmlqeqyay ekphvvcgdq
     3901 lvhspymqcl aslavglhld qllcnppvpp hhqnclpdpa swnpnewawl ecfsttikaa
     3961 ealtngaqfp esftvpdlep vpedelvflm dnskwingmd eqimswatsr pedwhlggkc
     4021 dvylwgagrh gqlaeagrnv mvpaaapsfs qaqqvicgqn ctfviqangt vlacgegsyg
     4081 rlgqgnsddl hvltvisalq gfvvtqlvts cgsdghsmal tesgevfswg dgdygklghg
     4141 nsdrqrrprq iealqgeevv qmscgfkhsa vvtsdgklft fgngdygrlg lgntsnkklp
     4201 ervtalegyq igqvacglnh tlavsadgsm vwafgdgdyg klglgnstak sspqkidvlc
     4261 gigikkvacg tqfsvaltkd ghvytfgqdr liglpegrar nhnrpqqipv lagviiedva
     4321 vgaehtlala sngdvyawgs nsegqlglgh tnhvreptlv tglqgknvrq isagrchsaa
     4381 wtappvppra pgvsvplqlg lpdtvppqyg alrevsihtv rarlrllyhf sdlmysswrl
     4441 lnlspnnqns tshynagtwg ivqgqlrpll aprvytlpmv rsigktmvqg knygpqitvk
     4501 ristrgrkck pifvqiarqv vklnasdlrl psrawkvklv gegaddaggv fddtitemcq
     4561 eletgivdll ipspnataev gynrdrflfn psacldehlm qfkflgilmg vairtkkpld
     4621 lhlaplvwkq lccvpltled leevdllyvq tlnsilhied sgiteesfhe mipldsfvgq
     4681 sadgkmvpii pggnsipltf snrkeyvera ieyrlhemdr qvaavregms wivpvpllsl
     4741 ltakqleqmv cgmpeisvev lkkvvryrev deqhqlvqwf whtleefsne ervlfmrfvs
     4801 grsrlpanta disqrfqimk vdrpydslpt sqtcffqlrl ppyssqlvma erlryainnc
     4861 rsidmdnyml srnvdnaegs dtdy
//
LOCUS       XP_047289183            4884 aa            linear   PRI 05-AUG-2025
DEFINITION  putative E3 ubiquitin-protein ligase HERC1 isoform X15 [Homo
            sapiens].
ACCESSION   XP_047289183
VERSION     XP_047289183.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433227.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4884
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4884
                     /product="putative E3 ubiquitin-protein ligase HERC1
                     isoform X15"
                     /calculated_mol_wt=534537
     Region          374..703
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          683..733
                     /region_name="RCC1"
                     /note="Regulator of chromosome condensation (RCC1) repeat;
                     pfam00415"
                     /db_xref="CDD:395335"
     Region          2041..2198
                     /region_name="SPRY_HERC1"
                     /note="SPRY domain in HERC1; cd12881"
                     /db_xref="CDD:293939"
     Region          2754..2797
                     /region_name="UBA_HERC1"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC1 and similar proteins; cd14401"
                     /db_xref="CDD:270584"
     Region          <3410..3801
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          3455..3498
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3512..3547
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3552..3599
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3608..3643
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3652..3688
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3695..3726
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3773..3809
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          4022..4358
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          4496..4864
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4501,4542,4553,4620,4798,4828..4829,4832..4836,4856,
                     4863)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4648,4651..4652,4654..4655,4658,4666,4668,
                     4672..4673,4675,4684,4689,4706,4710)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4884
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /coded_by="XM_047433227.1:149..14803"
                     /db_xref="GeneID:8925"
                     /db_xref="HGNC:HGNC:4867"
                     /db_xref="MIM:605109"
ORIGIN      
        1 matmippvkl kwlehlnssw itedsesiat regvavlysk lvsnkevvpl pqqvlclkgp
       61 qlpdferesl ssdeqdhyld allssqlala kmvcsdspfa galrkrllvl qrvfyalsnk
      121 yhdkgkvkqq qhspesssgs advhsvserp rsstdaliem gvrtglsllf allrqswmmp
      181 vsgpglslcn dvihtaievv sslpplslan eskippmgld clsqvttflk gvtipnsgad
      241 tlgrrlasel llglaaqrgs lryllewiem algasavvht mekgkllssq egmisfdcfm
      301 tilmqmrrsl gssadrsqwr eptrtsdglc slyeaalclf eevcrmasdy srtcaspdsi
      361 qtgdapivse tcevyvwgsn sshqlvegtq ekilqpklap sfsdaqtiea gqyctfvist
      421 dgsvracgkg sygrlglgds nnqstlkklt fephrsikkv ssskgsdght lafttegevf
      481 swgdgdygkl ghgnsstqky pkliqgplqg kvvvcvsagy rhsaavtedg elytwgegdf
      541 grlghgdsns rniptlvkdi snvgevscgs shtialskdg rtvwsfgggd ngklghgdtn
      601 rvykpkviea lqgmfirkvc agsqsslalt stgqvyawgc gaclgcgsse atalrpklie
      661 elaatrivdv sigdshclal shdnevyawg nnsmgqcgqg nstgpitkpk kvsgldgiai
      721 qqisagtshs lawtalprdr qvvawhrpyc vdleestfsh lrsflerycd kinseipplp
      781 fpssrehhsf lklclkllsn hlalalaggv atsilgrqag plrnllfrlm dstvpdeiqe
      841 vvietlsvga tmllpplrer mellhsllpq gpdrweslsk gqrmqldiil tslqdhthva
      901 sllgysspsd aadlssvctg ygnlsdqpyg tqschpdthl aeilmktllr nlgfytdqaf
      961 geleknsdkf llgtsssens qpahlhellc slqkqllafc hinnisenss svallhkhlq
     1021 lllphatdiy srsanllkes pwngsvgekl rdviyvsaag smlcqivnsl lllpvsvarp
     1081 llsylldllp pldclnrllp aadlledqel qwplhggpel idpaglplpq paqswvwlvd
     1141 lertiallig rclggmlqgs pvspeeqdta ywmktplfsd gvemdtpqld kcmsclleva
     1201 lsgneeqkpf dyklrpeiav yvdlalgcsk eparslwism qdyavskdwd satlsnesll
     1261 dtvsrfvlaa llkhtnllsq acgesryqpg khlsevyrcv ykvrsrllac knleliqtrs
     1321 ssrdrwisen qdsadvdpqe hsftrtidee aemeeqaerd reeghpeped eeeerehevm
     1381 tagnlvfvlh vteifqcfls arevarsrdr drmnsgagsg araddpppqs qqerrvstdl
     1441 pegqdvytaa cnsvihrcal lilgvspvid elqkrreegq lqqpstsase ggglmtrses
     1501 ltaesrlvht spnyrliksr sesdlsqpes deegyalsgr rnvdldlaas hrkrgpmhsq
     1561 leslsdswar lkhsrdwlcn ssysfesdfd ltkslgvhtl ienvvsfvsg dvgnapgfke
     1621 peesmstspq asiiameqqq lraelrleal hqilvllsgm eekgsislag srlssgfqss
     1681 tlltsvrlqf lagcfglgtv ghtggkgesg rlhhyqdgir aakrniqiei qvavhkiyqq
     1741 lsatleralq ankhhieaqq rlllvtvfal svhyqpvdvs laistgllnv lsqlcgtdtm
     1801 lgqplqllpk tgvsqlstal kvastrllqi laittgtyad klspkvvqsl ldllcsqlkn
     1861 llsqtgvlhm asfgegeqed geeeekkvds sgetekkdfr aalrkqhaae lhlgdflvfl
     1921 rrvvsskaiq skmaspkwte vllniasqkc ssgiplvgnl rtrllalhvl eavlpacesg
     1981 veddqmaqiv erlfsllsdc mwetpiaqak haiqikekeq eiklqkqgel eeedenlpiq
     2041 evsfdpekaq cclvengqil thgsggkgyg lastgvtsgc yqwkfyivke nrgnegtcvg
     2101 vsrwpvhdfn hrttsdmwly raysgnlyhn geqtltlssf tqgdfitcvl dmeartisfg
     2161 kngeepklaf edvdaaelyp cvmfyssnpg ekvkicdmqm rgtprdllpg dpicspvaav
     2221 laeatiqlir ilhrtdrwty cinkkmmerl hkikicikes gqklkksrsv qsreenemre
     2281 ekeskeeekg khtrhgladl selqlrtlci evwpvlavig gvdaglrvgg rcvhkqtgrh
     2341 atllgvvkeg stsakvqwde aeitisdtpl ynlepceplp fdvarfrglt asvlldltyl
     2401 tgvhedmgkq stkrhekkhr heseekgdve qkpesesald mrtgltsddv ksqsttssks
     2461 eneiasfsld ptlpsvesqh qitegkrknh ehmsknhdva qseiravqls ylylgamksl
     2521 sallgcskya elllipkvla enghnsdcas spvvhedvem raalqflmrh mvkravmrsp
     2581 ikralgladl eraqamiykl vvhglledqf ggkikqeidq qaeesdpaqq aqtpvttsps
     2641 assttsfmss sledtttatt pvtdtetvpa sespgvmpls llrqmfssyp tttvlptrra
     2701 qtppisslpt spsdevgrrq sltspdsqsa rpanrtalsd pssrlstspp ppaiavplle
     2761 mgfslrqiak ameatgarge adaqnitvla mwmiehpghe deeepqsgst adsrpgaavl
     2821 gsggksndpc ylqspgdips adaaemeegf sespdnldht enaasgsgps argrsavtrr
     2881 hkfdlaartl laraaglyrs vqahrnqsrr egislqqdpg alydfnldee leidlddeam
     2941 eamfgqdlts dndilgmwip evldwptwhv cesedreevv vcelcecsvv sfnqhmkrnh
     3001 pgcgrsanrq gyrsngsyvd gwfggecgsg npyyllcgtc rekylamktk skstsseryk
     3061 gqapdligkq dsvyeedwdm ldvdedeklt geeefellag plglndrriv pepvqfpdsd
     3121 plgasvamvt atnsmeetlm qielcfsgch gsveksssgr itlgeqaaal anphdrvval
     3181 rrvtaaaqvl lartmvmral sllsvsgssc slaagleslg ltdirtlvrl mclaaagrag
     3241 lstspsamas tsersrgghs kankpiscla ylstavgcla snapsaakll vqlctqnlis
     3301 aatgvnlttv ddsiqrkflp sflrgiaeen klvtspnfvv tqalvallad kgaklrpnyd
     3361 ksevekkgli aqlyahpsyd psavgplela nalaacclss rlssqhrqwa aqqlvrtlaa
     3421 hdrdnqttlq tladmggdlr kcsfikleah qnrvmtcvwc nkkgllatsg ndgtirvwnv
     3481 tkkqyslqqt cvfnrlegda eeslgspsdp sfspvswsis gkylagalek mvniwqvngg
     3541 kglvdiqphw vsalawpeeg patawsgesp elllvgrmdg slglievvdv stmhrreleh
     3601 cyrkdvsvtc iawfsedrpf avgyfdgkll lgtkeplekg givlidahkd tlismkwdpt
     3661 ghilmtcake dsvklwgsis gcwcclhslc hpsivngiaw crlpgkgskl qllmatgcqs
     3721 glvcvwripq dttqtnvtsa egwweqesnc qdgyrkssga kcvyqlrghi tpvrtvafss
     3781 dglalvsggl gglmniwslr dgsvlqtvvi gsgaiqttvw ipevgvaacs nrskdvlvvn
     3841 ctaewaaanh vlatcrtalk qqgvlglnma pcmraflerl pmmlqeqyay ekphvvcgdq
     3901 lvhspymqcl aslavglhld qllcnppvpp hhqnclpdpa swnpnewawl ecfsttikaa
     3961 ealtngaqfp esftvpdlep vpedelvflm dnskwingmd eqimswatsr pedwhlggkc
     4021 dvylwgagrh gqlaeagrnv mvpaaapsfs qaqqvicgqn ctfviqangt vlacgegsyg
     4081 rlgqgnsddl hvltvisalq gfvvtqlvts cgsdghsmal tesgevfswg dgdygklghg
     4141 nsdrqrrprq iealqgeevv qmscgfkhsa vvtsdgklft fgngdygrlg lgntsnkklp
     4201 ervtalegyq igqvacglnh tlavsadgsm vwafgdgdyg klglgnstak sspqkidvlc
     4261 gigikkvacg tqfsvaltkd ghvytfgqdr liglpegrar nhnrpqqipv lagviiedva
     4321 vgaehtlala sngdvyawgs nsegqlglgh tnhvreptlv tglqgknvrq isagrchsaa
     4381 wtappvppra pgvsvplqlg lpdtvppqyg alrevsihtv rarlrllyhf sdlmysswrl
     4441 lnlspnnqns tshynagtwg ivqgqlrpll aprvytlpmv rsigktmvqg knygpqitvk
     4501 ristrgrkck pifvqiarqv vklnasdlrl psrawkvklv gegaddaggv fddtitemcq
     4561 eletgivdll ipspnataev gynrdrflfn psacldehlm qfkflgilmg vairtkkpld
     4621 lhlaplvwkq lccvpltled leevdllyvq tlnsilhied sgiteesfhe mipldsfvgq
     4681 sadgkmvpii pggnsipltf snrkeyvera ieyrlhemdr qvaavregms wivpvpllsl
     4741 ltakqleqmv cgmpeisvev lkkvvryrev deqhqlvqwf whtleefsne ervlfmrfvs
     4801 grsrlpanta disqrfqimk vdrpydslpt sqtcffqlrl ppyssqlvma erlryainnc
     4861 rsidmdnyml srnvdnaegs dtdy
//
LOCUS       XP_047289184            4883 aa            linear   PRI 05-AUG-2025
DEFINITION  putative E3 ubiquitin-protein ligase HERC1 isoform X16 [Homo
            sapiens].
ACCESSION   XP_047289184
VERSION     XP_047289184.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433228.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4883
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4883
                     /product="putative E3 ubiquitin-protein ligase HERC1
                     isoform X16"
                     /calculated_mol_wt=534659
     Region          374..703
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          683..733
                     /region_name="RCC1"
                     /note="Regulator of chromosome condensation (RCC1) repeat;
                     pfam00415"
                     /db_xref="CDD:395335"
     Region          2063..2220
                     /region_name="SPRY_HERC1"
                     /note="SPRY domain in HERC1; cd12881"
                     /db_xref="CDD:293939"
     Region          2776..2819
                     /region_name="UBA_HERC1"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC1 and similar proteins; cd14401"
                     /db_xref="CDD:270584"
     Region          <3409..3800
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          3454..3497
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3511..3546
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3551..3598
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3607..3642
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3651..3687
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3694..3725
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3772..3808
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          4021..4357
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          4495..4863
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4500,4541,4552,4619,4797,4827..4828,4831..4835,4855,
                     4862)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4647,4650..4651,4653..4654,4657,4665,4667,
                     4671..4672,4674,4683,4688,4705,4709)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4883
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /coded_by="XM_047433228.1:154..14805"
                     /db_xref="GeneID:8925"
                     /db_xref="HGNC:HGNC:4867"
                     /db_xref="MIM:605109"
ORIGIN      
        1 matmippvkl kwlehlnssw itedsesiat regvavlysk lvsnkevvpl pqqvlclkgp
       61 qlpdferesl ssdeqdhyld allssqlala kmvcsdspfa galrkrllvl qrvfyalsnk
      121 yhdkgkvkqq qhspesssgs advhsvserp rsstdaliem gvrtglsllf allrqswmmp
      181 vsgpglslcn dvihtaievv sslpplslan eskippmgld clsqvttflk gvtipnsgad
      241 tlgrrlasel llglaaqrgs lryllewiem algasavvht mekgkllssq egmisfdcfm
      301 tilmqmrrsl gssadrsqwr eptrtsdglc slyeaalclf eevcrmasdy srtcaspdsi
      361 qtgdapivse tcevyvwgsn sshqlvegtq ekilqpklap sfsdaqtiea gqyctfvist
      421 dgsvracgkg sygrlglgds nnqstlkklt fephrsikkv ssskgsdght lafttegevf
      481 swgdgdygkl ghgnsstqky pkliqgplqg kvvvcvsagy rhsaavtedg elytwgegdf
      541 grlghgdsns rniptlvkdi snvgevscgs shtialskdg rtvwsfgggd ngklghgdtn
      601 rvykpkviea lqgmfirkvc agsqsslalt stgqvyawgc gaclgcgsse atalrpklie
      661 elaatrivdv sigdshclal shdnevyawg nnsmgqcgqg nstgpitkpk kvsgldgiai
      721 qqisagtshs lawtalprdr qvvawhrpyc vdleestfsh lrsflerycd kinseipplp
      781 fpssrehhsf lklclkllsn hlalalaggv atsilgrqag plrnllfrlm dstvpdeiqe
      841 vvietlsvga tmllpplrer mellhsllpq gpdrweslsk gqrmqldiil tslqdhthva
      901 sllgysspsd aadlssvctg ygnlsdqpyg tqschpdthl aeilmktllr nlgfytdqaf
      961 geleknsdkf llgtsssens qpahlhellc slqkqllafc hinnisenss svallhkhlq
     1021 lllphatdiy srsanllkes pwngsvgekl rdviyvsaag smlcqivnsl lllpvsvarp
     1081 llsylldllp pldclnrllp aadlledqel qwplhggpel idpaglplpq paqswvwlvd
     1141 lertiallig rclggmlqgs pvspeeqdta ywmktplfsd gvemdtpqld kcmsclleva
     1201 lsgneeqkpf dyklrpeiav yvdlalgcsk eparslwism qdyavskdwd satlsnesll
     1261 dtvsrfvlaa llkhtnllsq acgesryqpg khlsevyrcv ykvrsrllac knleliqtrs
     1321 ssrdrwisen qdsadvdpqe hsftrtidee aemeeqaerd reeghpeped eeeerehevm
     1381 tagnlvfvlh vteifqcfls arevarsrdr drmnsgagsg araddpppqs qqerrvstdl
     1441 pegqdvytaa cnsvihrcal lilgvspvid elqkrreegq lqqpstsase ggglmtrses
     1501 ltaesrlvht spnyrliksr sesdlsqpes deegyalsgr rnvdldlaas hrkrvylllf
     1561 gqlsprkkks fkqvhdgpmh sqleslsdsw arlkhsrdwl cnssysfesd fdltkslgvh
     1621 tlienvvsfv sgdvgnapgf kepeesmsts pqasiiameq qqlraelrle alhqilvlls
     1681 gmeekgsisl agsrlssgfq sstlltsvrl qflagcfglg tvghtggkge sgrlhhyqdg
     1741 iraakrniqi eiqvavhkiy qqlsatlera lqankhhiea qqrlllvtvf alsvhyqpvd
     1801 vslaistgll nvlsqlcgtd tmlgqplqll pktgvsqlst alkvastrll qilaittgty
     1861 adklspkvvq slldllcsql knllsqtgvl hmasfgegeq edgeeeekkv dssgetekkd
     1921 fraalrkqha aelhlgdflv flrrvvsska iqskmaspkw tevllniasq kcssgiplvg
     1981 nlrtrllalh vleavlpace sgveddqmaq iverlfslls dcmwetpiaq akhaiqikek
     2041 eqeiklqkqg eleeedenlp iqevsfdpek aqcclvengq ilthgsggkg yglastgvts
     2101 gcyqwkfyiv kenrgnegtc vgvsrwpvhd fnhrttsdmw lyraysgnly hngeqtltls
     2161 sftqgdfitc vldmeartis fgkngeepkl afedvdaael ypcvmfyssn pgekvkicdm
     2221 qmrgtprdll pgdpicspva avlaeatiql irilhrtdrw tycinkkmme rlhkikicik
     2281 esgqklkksr svqsreenem reekeskeee kgkhtrhgla dlselqlrtl cievwpvlav
     2341 iggvdaglrv ggrcvhkqtg rhatllgvvk egstsakvqw deaeitisdt plynlepcep
     2401 lpfdvarfrg ltasvlldlt yltgvhedmg kqstkrhekk hrheseekgd veqkpesesa
     2461 ldmrtgltsd dvksqsttss kseneiasfs ldptlpsves qhqitegkrk nhehmsknhd
     2521 vaqseiravq lsylylgamk slsallgcsk yaelllipkv laenghnsdc asspvvhedv
     2581 emraalqflm rhmvkravmr spikralgla dleraqamiy klvvhglled qfggkikqei
     2641 dqqaeesdpa qqaqtpvtts psassttsfm sssledttta ttpvtdtetv pasespgvmp
     2701 lsllrqmfss yptttvlptr raqtppissl ptspsdevgr rqsltspdsq sarpanrtal
     2761 sdpssrlsts ppppaiavpl lemgfslrqi akameatgar geadaqnitv lamwmiehpg
     2821 hedeeepqsg stadsrpgaa vlgsggksnd pcylqspgdi psadaaemee gfsespdnld
     2881 htenaasgsg psargrsavt rrhkfdlaar tllaraagly rsvqahrnqs rregislqqd
     2941 pgalydfnld eeleidldde ameamfgqdl tsdndilgmw ipevldwptw hvcesedree
     3001 vvvcelcecs vvsfnqhmkr nhpgcgrsan rqgyrsngsy vdgwfggecg sgnpyyllcg
     3061 tcrekylamk tkskstsser ykgqapdlig kqdsvyedwd mldvdedekl tgeeefella
     3121 gplglndrri vpepvqfpds dplgasvamv tatnsmeetl mqigchgsve ksssgritlg
     3181 eqaaalanph drvvalrrvt aaaqvllart mvmralslls vsgsscslaa gleslgltdi
     3241 rtlvrlmcla aagraglsts psamastser srgghskank pisclaylst avgclasnap
     3301 saakllvqlc tqnlisaatg vnlttvddsi qrkflpsflr giaeenklvt spnfvvtqal
     3361 valladkgak lrpnydksev ekkgplelan alaacclssr lssqhrqwaa qqlvrtlaah
     3421 drdnqttlqt ladmggdlrk csfikleahq nrvmtcvwcn kkgllatsgn dgtirvwnvt
     3481 kkqyslqqtc vfnrlegdae eslgspsdps fspvswsisg kylagalekm vniwqvnggk
     3541 glvdiqphwv salawpeegp atawsgespe lllvgrmdgs lglievvdvs tmhrrelehc
     3601 yrkdvsvtci awfsedrpfa vgyfdgklll gtkeplekgg ivlidahkdt lismkwdptg
     3661 hilmtcaked svklwgsisg cwcclhslch psivngiawc rlpgkgsklq llmatgcqsg
     3721 lvcvwripqd ttqtnvtsae gwweqesncq dgyrkssgak cvyqlrghit pvrtvafssd
     3781 glalvsgglg glmniwslrd gsvlqtvvig sgaiqttvwi pevgvaacsn rskdvlvvnc
     3841 taewaaanhv latcrtalkq qgvlglnmap cmraflerlp mmlqeqyaye kphvvcgdql
     3901 vhspymqcla slavglhldq llcnppvpph hqnclpdpas wnpnewawle cfsttikaae
     3961 altngaqfpe sftvpdlepv pedelvflmd nskwingmde qimswatsrp edwhlggkcd
     4021 vylwgagrhg qlaeagrnvm vpaaapsfsq aqqvicgqnc tfviqangtv lacgegsygr
     4081 lgqgnsddlh vltvisalqg fvvtqlvtsc gsdghsmalt esgevfswgd gdygklghgn
     4141 sdrqrrprqi ealqgeevvq mscgfkhsav vtsdgklftf gngdygrlgl gntsnkklpe
     4201 rvtalegyqi gqvacglnht lavsadgsmv wafgdgdygk lglgnstaks spqkidvlcg
     4261 igikkvacgt qfsvaltkdg hvytfgqdrl iglpegrarn hnrpqqipvl agviiedvav
     4321 gaehtlalas ngdvyawgsn segqlglght nhvreptlvt glqgknvrqi sagrchsaaw
     4381 tappvpprap gvsvplqlgl pdtvppqyga lrevsihtvr arlrllyhfs dlmysswrll
     4441 nlspnnqnst shynagtwgi vqgqlrplla prvytlpmvr sigktmvqgk nygpqitvkr
     4501 istrgrkckp ifvqiarqvv klnasdlrlp srawkvklvg egaddaggvf ddtitemcqe
     4561 letgivdlli pspnataevg ynrdrflfnp sacldehlmq fkflgilmgv airtkkpldl
     4621 hlaplvwkql ccvpltledl eevdllyvqt lnsilhieds giteesfhem ipldsfvgqs
     4681 adgkmvpiip ggnsipltfs nrkeyverai eyrlhemdrq vaavregmsw ivpvpllsll
     4741 takqleqmvc gmpeisvevl kkvvryrevd eqhqlvqwfw htleefsnee rvlfmrfvsg
     4801 rsrlpantad isqrfqimkv drpydslpts qtcffqlrlp pyssqlvmae rlryainncr
     4861 sidmdnymls rnvdnaegsd tdy
//
LOCUS       XP_016878194            4883 aa            linear   PRI 05-AUG-2025
DEFINITION  putative E3 ubiquitin-protein ligase HERC1 isoform X17 [Homo
            sapiens].
ACCESSION   XP_016878194
VERSION     XP_016878194.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022705.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4883
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4883
                     /product="putative E3 ubiquitin-protein ligase HERC1
                     isoform X17"
                     /calculated_mol_wt=534463
     Region          374..703
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          683..733
                     /region_name="RCC1"
                     /note="Regulator of chromosome condensation (RCC1) repeat;
                     pfam00415"
                     /db_xref="CDD:395335"
     Region          2032..2189
                     /region_name="SPRY_HERC1"
                     /note="SPRY domain in HERC1; cd12881"
                     /db_xref="CDD:293939"
     Region          2753..2796
                     /region_name="UBA_HERC1"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC1 and similar proteins; cd14401"
                     /db_xref="CDD:270584"
     Region          <3409..3800
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          3454..3497
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3511..3546
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3551..3598
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3607..3642
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3651..3687
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3694..3725
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3772..3808
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          4021..4357
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          4495..4863
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4500,4541,4552,4619,4797,4827..4828,4831..4835,4855,
                     4862)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4647,4650..4651,4653..4654,4657,4665,4667,
                     4671..4672,4674,4683,4688,4705,4709)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4883
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /coded_by="XM_017022705.2:149..14800"
                     /db_xref="GeneID:8925"
                     /db_xref="HGNC:HGNC:4867"
                     /db_xref="MIM:605109"
ORIGIN      
        1 matmippvkl kwlehlnssw itedsesiat regvavlysk lvsnkevvpl pqqvlclkgp
       61 qlpdferesl ssdeqdhyld allssqlala kmvcsdspfa galrkrllvl qrvfyalsnk
      121 yhdkgkvkqq qhspesssgs advhsvserp rsstdaliem gvrtglsllf allrqswmmp
      181 vsgpglslcn dvihtaievv sslpplslan eskippmgld clsqvttflk gvtipnsgad
      241 tlgrrlasel llglaaqrgs lryllewiem algasavvht mekgkllssq egmisfdcfm
      301 tilmqmrrsl gssadrsqwr eptrtsdglc slyeaalclf eevcrmasdy srtcaspdsi
      361 qtgdapivse tcevyvwgsn sshqlvegtq ekilqpklap sfsdaqtiea gqyctfvist
      421 dgsvracgkg sygrlglgds nnqstlkklt fephrsikkv ssskgsdght lafttegevf
      481 swgdgdygkl ghgnsstqky pkliqgplqg kvvvcvsagy rhsaavtedg elytwgegdf
      541 grlghgdsns rniptlvkdi snvgevscgs shtialskdg rtvwsfgggd ngklghgdtn
      601 rvykpkviea lqgmfirkvc agsqsslalt stgqvyawgc gaclgcgsse atalrpklie
      661 elaatrivdv sigdshclal shdnevyawg nnsmgqcgqg nstgpitkpk kvsgldgiai
      721 qqisagtshs lawtalprdr qvvawhrpyc vdleestfsh lrsflerycd kinseipplp
      781 fpssrehhsf lklclkllsn hlalalaggv atsilgrqag plrnllfrlm dstvpdeiqe
      841 vvietlsvga tmllpplrer mellhsllpq gpdrweslsk gqrmqldiil tslqdhthva
      901 sllgysspsd aadlssvctg ygnlsdqpyg tqschpdthl aeilmktllr nlgfytdqaf
      961 geleknsdkf llgtsssens qpahlhellc slqkqllafc hinnisenss svallhkhlq
     1021 lllphatdiy srsanllkes pwngsvgekl rdviyvsaag smlcqivnsl lllpvsvarp
     1081 llsylldllp pldclnrllp aadlledqel qwplhggpel idpaglplpq paqswvwlvd
     1141 lertiallig rclggmlqgs pvspeeqdta ywmktplfsd gvemdtpqld kcmsclleva
     1201 lsgneeqkpf dyklrpeiav yvdlalgcsk eparslwism qdyavskdwd satlsnesll
     1261 dtvsrfvlaa llkhtnllsq acgesryqpg khlsevyrcv ykvrsrllac knleliqtrs
     1321 ssrdrwisen qdsadvdpqe hsftrtidee aemeeqaerd reeghpeped eeeerehevm
     1381 tagkifqcfl sarevarsrd rdrmnsgags garaddpppq sqqerrvstd lpegqdvyta
     1441 acnsvihrca llilgvspvi delqkrreeg qlqqpstsas eggglmtrse sltaesrlvh
     1501 tspnyrliks rsesdlsqpe sdeegyalsg rrnvdldlaa shrkrgpmhs qleslsdswa
     1561 rlkhsrdwlc nssysfesdf dltkslgvht lienvvsfvs gdvgnapgfk epeesmstsp
     1621 qasiiameqq qlraelrlea lhqilvllsg meekgsisla gsrlssgfqs stlltsvrlq
     1681 flagcfglgt vghtggkges grlhhyqdgi raakrniqie iqvavhkiyq qlsatleral
     1741 qankhhieaq qrlllvtvfa lsvhyqpvdv slaistglln vlsqlcgtdt mlgqplqllp
     1801 ktgvsqlsta lkvastrllq ilaittgtya dklspkvvqs lldllcsqlk nllsqtgvlh
     1861 masfgegeqe dgeeeekkvd ssgetekkdf raalrkqhaa elhlgdflvf lrrvvsskai
     1921 qskmaspkwt evllniasqk cssgiplvgn lrtrllalhv leavlpaces gveddqmaqi
     1981 verlfsllsd cmwetpiaqa khaiqikeke qeiklqkqge leeedenlpi qevsfdpeka
     2041 qcclvengqi lthgsggkgy glastgvtsg cyqwkfyivk enrgnegtcv gvsrwpvhdf
     2101 nhrttsdmwl yraysgnlyh ngeqtltlss ftqgdfitcv ldmeartisf gkngeepkla
     2161 fedvdaaely pcvmfyssnp gekvkicdmq mrgtprdllp gdpicspvaa vlaeatiqli
     2221 rilhrtdrwt ycinkkmmer lhkikicike sgqklkksrs vqsreenemr eekeskeeek
     2281 gkhtrhglad lselqlrtlc ievwpvlavi ggvdaglrvg grcvhkqtgr hatllgvvke
     2341 gstsakvqwd eaeitisfpt fwspsdtply nlepceplpf dvarfrglta svlldltylt
     2401 gvhedmgkqs tkrhekkhrh eseekgdveq kpesesaldm rtgltsddvk sqsttsskse
     2461 neiasfsldp tlpsvesqhq itegkrknhe hmsknhdvaq seiravqlsy lylgamksls
     2521 allgcskyae lllipkvlae nghnsdcass pvvhedvemr aalqflmrhm vkravmrspi
     2581 kralgladle raqamiyklv vhglledqfg gkikqeidqq aeesdpaqqa qtpvttspsa
     2641 ssttsfmsss ledtttattp vtdtetvpas espgvmplsl lrqmfssypt ttvlptrraq
     2701 tppisslpts psdevgrrqs ltspdsqsar panrtalsdp ssrlstsppp paiavpllem
     2761 gfslrqiaka meatgargea daqnitvlam wmiehpghed eeepqsgsta dsrpgaavlg
     2821 sggksndpcy lqspgdipsa daaemeegfs espdnldhte naasgsgpsa rgrsavtrrh
     2881 kfdlaartll araaglyrsv qahrnqsrre gislqqdpga lydfnldeel eidlddeame
     2941 amfgqdltsd ndilgmwipe vldwptwhvc esedreevvv celcecsvvs fnqhmkrnhp
     3001 gcgrsanrqg yrsngsyvdg wfggecgsgn pyyllcgtcr ekylamktks kstsserykg
     3061 qapdligkqd svyeedwdml dvdedekltg eeefellagp lglndrrivp epvqfpdsdp
     3121 lgasvamvta tnsmeetlmq ielcfsgchg sveksssgri tlgeqaaala nphdrvvalr
     3181 rvtaaaqvll artmvmrals llsvsgsscs laagleslgl tdirtlvrlm claaagragl
     3241 stspsamast sersrgghsk ankpisclay lstavgclas napsaakllv qlctqnlisa
     3301 atgvnlttvd dsiqrkflps flrgiaeenk lvtspnfvvt qalvalladk gaklrpnydk
     3361 sevekkglia qlyahpsydp savgplelan alaacclssr lssqhrqwaa qqlvrtlaah
     3421 drdnqttlqt ladmggdlrk csfikleahq nrvmtcvwcn kkgllatsgn dgtirvwnvt
     3481 kkqyslqqtc vfnrlegdae eslgspsdps fspvswsisg kylagalekm vniwqvnggk
     3541 glvdiqphwv salawpeegp atawsgespe lllvgrmdgs lglievvdvs tmhrrelehc
     3601 yrkdvsvtci awfsedrpfa vgyfdgklll gtkeplekgg ivlidahkdt lismkwdptg
     3661 hilmtcaked svklwgsisg cwcclhslch psivngiawc rlpgkgsklq llmatgcqsg
     3721 lvcvwripqd ttqtnvtsae gwweqesncq dgyrkssgak cvyqlrghit pvrtvafssd
     3781 glalvsgglg glmniwslrd gsvlqtvvig sgaiqttvwi pevgvaacsn rskdvlvvnc
     3841 taewaaanhv latcrtalkq qgvlglnmap cmraflerlp mmlqeqyaye kphvvcgdql
     3901 vhspymqcla slavglhldq llcnppvpph hqnclpdpas wnpnewawle cfsttikaae
     3961 altngaqfpe sftvpdlepv pedelvflmd nskwingmde qimswatsrp edwhlggkcd
     4021 vylwgagrhg qlaeagrnvm vpaaapsfsq aqqvicgqnc tfviqangtv lacgegsygr
     4081 lgqgnsddlh vltvisalqg fvvtqlvtsc gsdghsmalt esgevfswgd gdygklghgn
     4141 sdrqrrprqi ealqgeevvq mscgfkhsav vtsdgklftf gngdygrlgl gntsnkklpe
     4201 rvtalegyqi gqvacglnht lavsadgsmv wafgdgdygk lglgnstaks spqkidvlcg
     4261 igikkvacgt qfsvaltkdg hvytfgqdrl iglpegrarn hnrpqqipvl agviiedvav
     4321 gaehtlalas ngdvyawgsn segqlglght nhvreptlvt glqgknvrqi sagrchsaaw
     4381 tappvpprap gvsvplqlgl pdtvppqyga lrevsihtvr arlrllyhfs dlmysswrll
     4441 nlspnnqnst shynagtwgi vqgqlrplla prvytlpmvr sigktmvqgk nygpqitvkr
     4501 istrgrkckp ifvqiarqvv klnasdlrlp srawkvklvg egaddaggvf ddtitemcqe
     4561 letgivdlli pspnataevg ynrdrflfnp sacldehlmq fkflgilmgv airtkkpldl
     4621 hlaplvwkql ccvpltledl eevdllyvqt lnsilhieds giteesfhem ipldsfvgqs
     4681 adgkmvpiip ggnsipltfs nrkeyverai eyrlhemdrq vaavregmsw ivpvpllsll
     4741 takqleqmvc gmpeisvevl kkvvryrevd eqhqlvqwfw htleefsnee rvlfmrfvsg
     4801 rsrlpantad isqrfqimkv drpydslpts qtcffqlrlp pyssqlvmae rlryainncr
     4861 sidmdnymls rnvdnaegsd tdy
//
LOCUS       XP_047289185            4883 aa            linear   PRI 05-AUG-2025
DEFINITION  putative E3 ubiquitin-protein ligase HERC1 isoform X17 [Homo
            sapiens].
ACCESSION   XP_047289185
VERSION     XP_047289185.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433229.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4883
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4883
                     /product="putative E3 ubiquitin-protein ligase HERC1
                     isoform X17"
                     /calculated_mol_wt=534463
     Region          374..703
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          683..733
                     /region_name="RCC1"
                     /note="Regulator of chromosome condensation (RCC1) repeat;
                     pfam00415"
                     /db_xref="CDD:395335"
     Region          2032..2189
                     /region_name="SPRY_HERC1"
                     /note="SPRY domain in HERC1; cd12881"
                     /db_xref="CDD:293939"
     Region          2753..2796
                     /region_name="UBA_HERC1"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC1 and similar proteins; cd14401"
                     /db_xref="CDD:270584"
     Region          <3409..3800
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          3454..3497
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3511..3546
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3551..3598
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3607..3642
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3651..3687
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3694..3725
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3772..3808
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          4021..4357
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          4495..4863
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4500,4541,4552,4619,4797,4827..4828,4831..4835,4855,
                     4862)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4647,4650..4651,4653..4654,4657,4665,4667,
                     4671..4672,4674,4683,4688,4705,4709)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4883
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /coded_by="XM_047433229.1:154..14805"
                     /db_xref="GeneID:8925"
                     /db_xref="HGNC:HGNC:4867"
                     /db_xref="MIM:605109"
ORIGIN      
        1 matmippvkl kwlehlnssw itedsesiat regvavlysk lvsnkevvpl pqqvlclkgp
       61 qlpdferesl ssdeqdhyld allssqlala kmvcsdspfa galrkrllvl qrvfyalsnk
      121 yhdkgkvkqq qhspesssgs advhsvserp rsstdaliem gvrtglsllf allrqswmmp
      181 vsgpglslcn dvihtaievv sslpplslan eskippmgld clsqvttflk gvtipnsgad
      241 tlgrrlasel llglaaqrgs lryllewiem algasavvht mekgkllssq egmisfdcfm
      301 tilmqmrrsl gssadrsqwr eptrtsdglc slyeaalclf eevcrmasdy srtcaspdsi
      361 qtgdapivse tcevyvwgsn sshqlvegtq ekilqpklap sfsdaqtiea gqyctfvist
      421 dgsvracgkg sygrlglgds nnqstlkklt fephrsikkv ssskgsdght lafttegevf
      481 swgdgdygkl ghgnsstqky pkliqgplqg kvvvcvsagy rhsaavtedg elytwgegdf
      541 grlghgdsns rniptlvkdi snvgevscgs shtialskdg rtvwsfgggd ngklghgdtn
      601 rvykpkviea lqgmfirkvc agsqsslalt stgqvyawgc gaclgcgsse atalrpklie
      661 elaatrivdv sigdshclal shdnevyawg nnsmgqcgqg nstgpitkpk kvsgldgiai
      721 qqisagtshs lawtalprdr qvvawhrpyc vdleestfsh lrsflerycd kinseipplp
      781 fpssrehhsf lklclkllsn hlalalaggv atsilgrqag plrnllfrlm dstvpdeiqe
      841 vvietlsvga tmllpplrer mellhsllpq gpdrweslsk gqrmqldiil tslqdhthva
      901 sllgysspsd aadlssvctg ygnlsdqpyg tqschpdthl aeilmktllr nlgfytdqaf
      961 geleknsdkf llgtsssens qpahlhellc slqkqllafc hinnisenss svallhkhlq
     1021 lllphatdiy srsanllkes pwngsvgekl rdviyvsaag smlcqivnsl lllpvsvarp
     1081 llsylldllp pldclnrllp aadlledqel qwplhggpel idpaglplpq paqswvwlvd
     1141 lertiallig rclggmlqgs pvspeeqdta ywmktplfsd gvemdtpqld kcmsclleva
     1201 lsgneeqkpf dyklrpeiav yvdlalgcsk eparslwism qdyavskdwd satlsnesll
     1261 dtvsrfvlaa llkhtnllsq acgesryqpg khlsevyrcv ykvrsrllac knleliqtrs
     1321 ssrdrwisen qdsadvdpqe hsftrtidee aemeeqaerd reeghpeped eeeerehevm
     1381 tagkifqcfl sarevarsrd rdrmnsgags garaddpppq sqqerrvstd lpegqdvyta
     1441 acnsvihrca llilgvspvi delqkrreeg qlqqpstsas eggglmtrse sltaesrlvh
     1501 tspnyrliks rsesdlsqpe sdeegyalsg rrnvdldlaa shrkrgpmhs qleslsdswa
     1561 rlkhsrdwlc nssysfesdf dltkslgvht lienvvsfvs gdvgnapgfk epeesmstsp
     1621 qasiiameqq qlraelrlea lhqilvllsg meekgsisla gsrlssgfqs stlltsvrlq
     1681 flagcfglgt vghtggkges grlhhyqdgi raakrniqie iqvavhkiyq qlsatleral
     1741 qankhhieaq qrlllvtvfa lsvhyqpvdv slaistglln vlsqlcgtdt mlgqplqllp
     1801 ktgvsqlsta lkvastrllq ilaittgtya dklspkvvqs lldllcsqlk nllsqtgvlh
     1861 masfgegeqe dgeeeekkvd ssgetekkdf raalrkqhaa elhlgdflvf lrrvvsskai
     1921 qskmaspkwt evllniasqk cssgiplvgn lrtrllalhv leavlpaces gveddqmaqi
     1981 verlfsllsd cmwetpiaqa khaiqikeke qeiklqkqge leeedenlpi qevsfdpeka
     2041 qcclvengqi lthgsggkgy glastgvtsg cyqwkfyivk enrgnegtcv gvsrwpvhdf
     2101 nhrttsdmwl yraysgnlyh ngeqtltlss ftqgdfitcv ldmeartisf gkngeepkla
     2161 fedvdaaely pcvmfyssnp gekvkicdmq mrgtprdllp gdpicspvaa vlaeatiqli
     2221 rilhrtdrwt ycinkkmmer lhkikicike sgqklkksrs vqsreenemr eekeskeeek
     2281 gkhtrhglad lselqlrtlc ievwpvlavi ggvdaglrvg grcvhkqtgr hatllgvvke
     2341 gstsakvqwd eaeitisfpt fwspsdtply nlepceplpf dvarfrglta svlldltylt
     2401 gvhedmgkqs tkrhekkhrh eseekgdveq kpesesaldm rtgltsddvk sqsttsskse
     2461 neiasfsldp tlpsvesqhq itegkrknhe hmsknhdvaq seiravqlsy lylgamksls
     2521 allgcskyae lllipkvlae nghnsdcass pvvhedvemr aalqflmrhm vkravmrspi
     2581 kralgladle raqamiyklv vhglledqfg gkikqeidqq aeesdpaqqa qtpvttspsa
     2641 ssttsfmsss ledtttattp vtdtetvpas espgvmplsl lrqmfssypt ttvlptrraq
     2701 tppisslpts psdevgrrqs ltspdsqsar panrtalsdp ssrlstsppp paiavpllem
     2761 gfslrqiaka meatgargea daqnitvlam wmiehpghed eeepqsgsta dsrpgaavlg
     2821 sggksndpcy lqspgdipsa daaemeegfs espdnldhte naasgsgpsa rgrsavtrrh
     2881 kfdlaartll araaglyrsv qahrnqsrre gislqqdpga lydfnldeel eidlddeame
     2941 amfgqdltsd ndilgmwipe vldwptwhvc esedreevvv celcecsvvs fnqhmkrnhp
     3001 gcgrsanrqg yrsngsyvdg wfggecgsgn pyyllcgtcr ekylamktks kstsserykg
     3061 qapdligkqd svyeedwdml dvdedekltg eeefellagp lglndrrivp epvqfpdsdp
     3121 lgasvamvta tnsmeetlmq ielcfsgchg sveksssgri tlgeqaaala nphdrvvalr
     3181 rvtaaaqvll artmvmrals llsvsgsscs laagleslgl tdirtlvrlm claaagragl
     3241 stspsamast sersrgghsk ankpisclay lstavgclas napsaakllv qlctqnlisa
     3301 atgvnlttvd dsiqrkflps flrgiaeenk lvtspnfvvt qalvalladk gaklrpnydk
     3361 sevekkglia qlyahpsydp savgplelan alaacclssr lssqhrqwaa qqlvrtlaah
     3421 drdnqttlqt ladmggdlrk csfikleahq nrvmtcvwcn kkgllatsgn dgtirvwnvt
     3481 kkqyslqqtc vfnrlegdae eslgspsdps fspvswsisg kylagalekm vniwqvnggk
     3541 glvdiqphwv salawpeegp atawsgespe lllvgrmdgs lglievvdvs tmhrrelehc
     3601 yrkdvsvtci awfsedrpfa vgyfdgklll gtkeplekgg ivlidahkdt lismkwdptg
     3661 hilmtcaked svklwgsisg cwcclhslch psivngiawc rlpgkgsklq llmatgcqsg
     3721 lvcvwripqd ttqtnvtsae gwweqesncq dgyrkssgak cvyqlrghit pvrtvafssd
     3781 glalvsgglg glmniwslrd gsvlqtvvig sgaiqttvwi pevgvaacsn rskdvlvvnc
     3841 taewaaanhv latcrtalkq qgvlglnmap cmraflerlp mmlqeqyaye kphvvcgdql
     3901 vhspymqcla slavglhldq llcnppvpph hqnclpdpas wnpnewawle cfsttikaae
     3961 altngaqfpe sftvpdlepv pedelvflmd nskwingmde qimswatsrp edwhlggkcd
     4021 vylwgagrhg qlaeagrnvm vpaaapsfsq aqqvicgqnc tfviqangtv lacgegsygr
     4081 lgqgnsddlh vltvisalqg fvvtqlvtsc gsdghsmalt esgevfswgd gdygklghgn
     4141 sdrqrrprqi ealqgeevvq mscgfkhsav vtsdgklftf gngdygrlgl gntsnkklpe
     4201 rvtalegyqi gqvacglnht lavsadgsmv wafgdgdygk lglgnstaks spqkidvlcg
     4261 igikkvacgt qfsvaltkdg hvytfgqdrl iglpegrarn hnrpqqipvl agviiedvav
     4321 gaehtlalas ngdvyawgsn segqlglght nhvreptlvt glqgknvrqi sagrchsaaw
     4381 tappvpprap gvsvplqlgl pdtvppqyga lrevsihtvr arlrllyhfs dlmysswrll
     4441 nlspnnqnst shynagtwgi vqgqlrplla prvytlpmvr sigktmvqgk nygpqitvkr
     4501 istrgrkckp ifvqiarqvv klnasdlrlp srawkvklvg egaddaggvf ddtitemcqe
     4561 letgivdlli pspnataevg ynrdrflfnp sacldehlmq fkflgilmgv airtkkpldl
     4621 hlaplvwkql ccvpltledl eevdllyvqt lnsilhieds giteesfhem ipldsfvgqs
     4681 adgkmvpiip ggnsipltfs nrkeyverai eyrlhemdrq vaavregmsw ivpvpllsll
     4741 takqleqmvc gmpeisvevl kkvvryrevd eqhqlvqwfw htleefsnee rvlfmrfvsg
     4801 rsrlpantad isqrfqimkv drpydslpts qtcffqlrlp pyssqlvmae rlryainncr
     4861 sidmdnymls rnvdnaegsd tdy
//
LOCUS       XP_047289186            4883 aa            linear   PRI 05-AUG-2025
DEFINITION  putative E3 ubiquitin-protein ligase HERC1 isoform X17 [Homo
            sapiens].
ACCESSION   XP_047289186
VERSION     XP_047289186.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433230.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4883
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4883
                     /product="putative E3 ubiquitin-protein ligase HERC1
                     isoform X17"
                     /calculated_mol_wt=534463
     Region          374..703
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          683..733
                     /region_name="RCC1"
                     /note="Regulator of chromosome condensation (RCC1) repeat;
                     pfam00415"
                     /db_xref="CDD:395335"
     Region          2032..2189
                     /region_name="SPRY_HERC1"
                     /note="SPRY domain in HERC1; cd12881"
                     /db_xref="CDD:293939"
     Region          2753..2796
                     /region_name="UBA_HERC1"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC1 and similar proteins; cd14401"
                     /db_xref="CDD:270584"
     Region          <3409..3800
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          3454..3497
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3511..3546
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3551..3598
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3607..3642
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3651..3687
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3694..3725
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3772..3808
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          4021..4357
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          4495..4863
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4500,4541,4552,4619,4797,4827..4828,4831..4835,4855,
                     4862)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4647,4650..4651,4653..4654,4657,4665,4667,
                     4671..4672,4674,4683,4688,4705,4709)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4883
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /coded_by="XM_047433230.1:474..15125"
                     /db_xref="GeneID:8925"
                     /db_xref="HGNC:HGNC:4867"
                     /db_xref="MIM:605109"
ORIGIN      
        1 matmippvkl kwlehlnssw itedsesiat regvavlysk lvsnkevvpl pqqvlclkgp
       61 qlpdferesl ssdeqdhyld allssqlala kmvcsdspfa galrkrllvl qrvfyalsnk
      121 yhdkgkvkqq qhspesssgs advhsvserp rsstdaliem gvrtglsllf allrqswmmp
      181 vsgpglslcn dvihtaievv sslpplslan eskippmgld clsqvttflk gvtipnsgad
      241 tlgrrlasel llglaaqrgs lryllewiem algasavvht mekgkllssq egmisfdcfm
      301 tilmqmrrsl gssadrsqwr eptrtsdglc slyeaalclf eevcrmasdy srtcaspdsi
      361 qtgdapivse tcevyvwgsn sshqlvegtq ekilqpklap sfsdaqtiea gqyctfvist
      421 dgsvracgkg sygrlglgds nnqstlkklt fephrsikkv ssskgsdght lafttegevf
      481 swgdgdygkl ghgnsstqky pkliqgplqg kvvvcvsagy rhsaavtedg elytwgegdf
      541 grlghgdsns rniptlvkdi snvgevscgs shtialskdg rtvwsfgggd ngklghgdtn
      601 rvykpkviea lqgmfirkvc agsqsslalt stgqvyawgc gaclgcgsse atalrpklie
      661 elaatrivdv sigdshclal shdnevyawg nnsmgqcgqg nstgpitkpk kvsgldgiai
      721 qqisagtshs lawtalprdr qvvawhrpyc vdleestfsh lrsflerycd kinseipplp
      781 fpssrehhsf lklclkllsn hlalalaggv atsilgrqag plrnllfrlm dstvpdeiqe
      841 vvietlsvga tmllpplrer mellhsllpq gpdrweslsk gqrmqldiil tslqdhthva
      901 sllgysspsd aadlssvctg ygnlsdqpyg tqschpdthl aeilmktllr nlgfytdqaf
      961 geleknsdkf llgtsssens qpahlhellc slqkqllafc hinnisenss svallhkhlq
     1021 lllphatdiy srsanllkes pwngsvgekl rdviyvsaag smlcqivnsl lllpvsvarp
     1081 llsylldllp pldclnrllp aadlledqel qwplhggpel idpaglplpq paqswvwlvd
     1141 lertiallig rclggmlqgs pvspeeqdta ywmktplfsd gvemdtpqld kcmsclleva
     1201 lsgneeqkpf dyklrpeiav yvdlalgcsk eparslwism qdyavskdwd satlsnesll
     1261 dtvsrfvlaa llkhtnllsq acgesryqpg khlsevyrcv ykvrsrllac knleliqtrs
     1321 ssrdrwisen qdsadvdpqe hsftrtidee aemeeqaerd reeghpeped eeeerehevm
     1381 tagkifqcfl sarevarsrd rdrmnsgags garaddpppq sqqerrvstd lpegqdvyta
     1441 acnsvihrca llilgvspvi delqkrreeg qlqqpstsas eggglmtrse sltaesrlvh
     1501 tspnyrliks rsesdlsqpe sdeegyalsg rrnvdldlaa shrkrgpmhs qleslsdswa
     1561 rlkhsrdwlc nssysfesdf dltkslgvht lienvvsfvs gdvgnapgfk epeesmstsp
     1621 qasiiameqq qlraelrlea lhqilvllsg meekgsisla gsrlssgfqs stlltsvrlq
     1681 flagcfglgt vghtggkges grlhhyqdgi raakrniqie iqvavhkiyq qlsatleral
     1741 qankhhieaq qrlllvtvfa lsvhyqpvdv slaistglln vlsqlcgtdt mlgqplqllp
     1801 ktgvsqlsta lkvastrllq ilaittgtya dklspkvvqs lldllcsqlk nllsqtgvlh
     1861 masfgegeqe dgeeeekkvd ssgetekkdf raalrkqhaa elhlgdflvf lrrvvsskai
     1921 qskmaspkwt evllniasqk cssgiplvgn lrtrllalhv leavlpaces gveddqmaqi
     1981 verlfsllsd cmwetpiaqa khaiqikeke qeiklqkqge leeedenlpi qevsfdpeka
     2041 qcclvengqi lthgsggkgy glastgvtsg cyqwkfyivk enrgnegtcv gvsrwpvhdf
     2101 nhrttsdmwl yraysgnlyh ngeqtltlss ftqgdfitcv ldmeartisf gkngeepkla
     2161 fedvdaaely pcvmfyssnp gekvkicdmq mrgtprdllp gdpicspvaa vlaeatiqli
     2221 rilhrtdrwt ycinkkmmer lhkikicike sgqklkksrs vqsreenemr eekeskeeek
     2281 gkhtrhglad lselqlrtlc ievwpvlavi ggvdaglrvg grcvhkqtgr hatllgvvke
     2341 gstsakvqwd eaeitisfpt fwspsdtply nlepceplpf dvarfrglta svlldltylt
     2401 gvhedmgkqs tkrhekkhrh eseekgdveq kpesesaldm rtgltsddvk sqsttsskse
     2461 neiasfsldp tlpsvesqhq itegkrknhe hmsknhdvaq seiravqlsy lylgamksls
     2521 allgcskyae lllipkvlae nghnsdcass pvvhedvemr aalqflmrhm vkravmrspi
     2581 kralgladle raqamiyklv vhglledqfg gkikqeidqq aeesdpaqqa qtpvttspsa
     2641 ssttsfmsss ledtttattp vtdtetvpas espgvmplsl lrqmfssypt ttvlptrraq
     2701 tppisslpts psdevgrrqs ltspdsqsar panrtalsdp ssrlstsppp paiavpllem
     2761 gfslrqiaka meatgargea daqnitvlam wmiehpghed eeepqsgsta dsrpgaavlg
     2821 sggksndpcy lqspgdipsa daaemeegfs espdnldhte naasgsgpsa rgrsavtrrh
     2881 kfdlaartll araaglyrsv qahrnqsrre gislqqdpga lydfnldeel eidlddeame
     2941 amfgqdltsd ndilgmwipe vldwptwhvc esedreevvv celcecsvvs fnqhmkrnhp
     3001 gcgrsanrqg yrsngsyvdg wfggecgsgn pyyllcgtcr ekylamktks kstsserykg
     3061 qapdligkqd svyeedwdml dvdedekltg eeefellagp lglndrrivp epvqfpdsdp
     3121 lgasvamvta tnsmeetlmq ielcfsgchg sveksssgri tlgeqaaala nphdrvvalr
     3181 rvtaaaqvll artmvmrals llsvsgsscs laagleslgl tdirtlvrlm claaagragl
     3241 stspsamast sersrgghsk ankpisclay lstavgclas napsaakllv qlctqnlisa
     3301 atgvnlttvd dsiqrkflps flrgiaeenk lvtspnfvvt qalvalladk gaklrpnydk
     3361 sevekkglia qlyahpsydp savgplelan alaacclssr lssqhrqwaa qqlvrtlaah
     3421 drdnqttlqt ladmggdlrk csfikleahq nrvmtcvwcn kkgllatsgn dgtirvwnvt
     3481 kkqyslqqtc vfnrlegdae eslgspsdps fspvswsisg kylagalekm vniwqvnggk
     3541 glvdiqphwv salawpeegp atawsgespe lllvgrmdgs lglievvdvs tmhrrelehc
     3601 yrkdvsvtci awfsedrpfa vgyfdgklll gtkeplekgg ivlidahkdt lismkwdptg
     3661 hilmtcaked svklwgsisg cwcclhslch psivngiawc rlpgkgsklq llmatgcqsg
     3721 lvcvwripqd ttqtnvtsae gwweqesncq dgyrkssgak cvyqlrghit pvrtvafssd
     3781 glalvsgglg glmniwslrd gsvlqtvvig sgaiqttvwi pevgvaacsn rskdvlvvnc
     3841 taewaaanhv latcrtalkq qgvlglnmap cmraflerlp mmlqeqyaye kphvvcgdql
     3901 vhspymqcla slavglhldq llcnppvpph hqnclpdpas wnpnewawle cfsttikaae
     3961 altngaqfpe sftvpdlepv pedelvflmd nskwingmde qimswatsrp edwhlggkcd
     4021 vylwgagrhg qlaeagrnvm vpaaapsfsq aqqvicgqnc tfviqangtv lacgegsygr
     4081 lgqgnsddlh vltvisalqg fvvtqlvtsc gsdghsmalt esgevfswgd gdygklghgn
     4141 sdrqrrprqi ealqgeevvq mscgfkhsav vtsdgklftf gngdygrlgl gntsnkklpe
     4201 rvtalegyqi gqvacglnht lavsadgsmv wafgdgdygk lglgnstaks spqkidvlcg
     4261 igikkvacgt qfsvaltkdg hvytfgqdrl iglpegrarn hnrpqqipvl agviiedvav
     4321 gaehtlalas ngdvyawgsn segqlglght nhvreptlvt glqgknvrqi sagrchsaaw
     4381 tappvpprap gvsvplqlgl pdtvppqyga lrevsihtvr arlrllyhfs dlmysswrll
     4441 nlspnnqnst shynagtwgi vqgqlrplla prvytlpmvr sigktmvqgk nygpqitvkr
     4501 istrgrkckp ifvqiarqvv klnasdlrlp srawkvklvg egaddaggvf ddtitemcqe
     4561 letgivdlli pspnataevg ynrdrflfnp sacldehlmq fkflgilmgv airtkkpldl
     4621 hlaplvwkql ccvpltledl eevdllyvqt lnsilhieds giteesfhem ipldsfvgqs
     4681 adgkmvpiip ggnsipltfs nrkeyverai eyrlhemdrq vaavregmsw ivpvpllsll
     4741 takqleqmvc gmpeisvevl kkvvryrevd eqhqlvqwfw htleefsnee rvlfmrfvsg
     4801 rsrlpantad isqrfqimkv drpydslpts qtcffqlrlp pyssqlvmae rlryainncr
     4861 sidmdnymls rnvdnaegsd tdy
//
LOCUS       XP_047289188            4883 aa            linear   PRI 05-AUG-2025
DEFINITION  putative E3 ubiquitin-protein ligase HERC1 isoform X17 [Homo
            sapiens].
ACCESSION   XP_047289188
VERSION     XP_047289188.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433232.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4883
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4883
                     /product="putative E3 ubiquitin-protein ligase HERC1
                     isoform X17"
                     /calculated_mol_wt=534463
     Region          374..703
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          683..733
                     /region_name="RCC1"
                     /note="Regulator of chromosome condensation (RCC1) repeat;
                     pfam00415"
                     /db_xref="CDD:395335"
     Region          2032..2189
                     /region_name="SPRY_HERC1"
                     /note="SPRY domain in HERC1; cd12881"
                     /db_xref="CDD:293939"
     Region          2753..2796
                     /region_name="UBA_HERC1"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC1 and similar proteins; cd14401"
                     /db_xref="CDD:270584"
     Region          <3409..3800
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          3454..3497
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3511..3546
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3551..3598
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3607..3642
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3651..3687
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3694..3725
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3772..3808
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          4021..4357
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          4495..4863
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4500,4541,4552,4619,4797,4827..4828,4831..4835,4855,
                     4862)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4647,4650..4651,4653..4654,4657,4665,4667,
                     4671..4672,4674,4683,4688,4705,4709)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4883
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /coded_by="XM_047433232.1:3471..18122"
                     /db_xref="GeneID:8925"
                     /db_xref="HGNC:HGNC:4867"
                     /db_xref="MIM:605109"
ORIGIN      
        1 matmippvkl kwlehlnssw itedsesiat regvavlysk lvsnkevvpl pqqvlclkgp
       61 qlpdferesl ssdeqdhyld allssqlala kmvcsdspfa galrkrllvl qrvfyalsnk
      121 yhdkgkvkqq qhspesssgs advhsvserp rsstdaliem gvrtglsllf allrqswmmp
      181 vsgpglslcn dvihtaievv sslpplslan eskippmgld clsqvttflk gvtipnsgad
      241 tlgrrlasel llglaaqrgs lryllewiem algasavvht mekgkllssq egmisfdcfm
      301 tilmqmrrsl gssadrsqwr eptrtsdglc slyeaalclf eevcrmasdy srtcaspdsi
      361 qtgdapivse tcevyvwgsn sshqlvegtq ekilqpklap sfsdaqtiea gqyctfvist
      421 dgsvracgkg sygrlglgds nnqstlkklt fephrsikkv ssskgsdght lafttegevf
      481 swgdgdygkl ghgnsstqky pkliqgplqg kvvvcvsagy rhsaavtedg elytwgegdf
      541 grlghgdsns rniptlvkdi snvgevscgs shtialskdg rtvwsfgggd ngklghgdtn
      601 rvykpkviea lqgmfirkvc agsqsslalt stgqvyawgc gaclgcgsse atalrpklie
      661 elaatrivdv sigdshclal shdnevyawg nnsmgqcgqg nstgpitkpk kvsgldgiai
      721 qqisagtshs lawtalprdr qvvawhrpyc vdleestfsh lrsflerycd kinseipplp
      781 fpssrehhsf lklclkllsn hlalalaggv atsilgrqag plrnllfrlm dstvpdeiqe
      841 vvietlsvga tmllpplrer mellhsllpq gpdrweslsk gqrmqldiil tslqdhthva
      901 sllgysspsd aadlssvctg ygnlsdqpyg tqschpdthl aeilmktllr nlgfytdqaf
      961 geleknsdkf llgtsssens qpahlhellc slqkqllafc hinnisenss svallhkhlq
     1021 lllphatdiy srsanllkes pwngsvgekl rdviyvsaag smlcqivnsl lllpvsvarp
     1081 llsylldllp pldclnrllp aadlledqel qwplhggpel idpaglplpq paqswvwlvd
     1141 lertiallig rclggmlqgs pvspeeqdta ywmktplfsd gvemdtpqld kcmsclleva
     1201 lsgneeqkpf dyklrpeiav yvdlalgcsk eparslwism qdyavskdwd satlsnesll
     1261 dtvsrfvlaa llkhtnllsq acgesryqpg khlsevyrcv ykvrsrllac knleliqtrs
     1321 ssrdrwisen qdsadvdpqe hsftrtidee aemeeqaerd reeghpeped eeeerehevm
     1381 tagkifqcfl sarevarsrd rdrmnsgags garaddpppq sqqerrvstd lpegqdvyta
     1441 acnsvihrca llilgvspvi delqkrreeg qlqqpstsas eggglmtrse sltaesrlvh
     1501 tspnyrliks rsesdlsqpe sdeegyalsg rrnvdldlaa shrkrgpmhs qleslsdswa
     1561 rlkhsrdwlc nssysfesdf dltkslgvht lienvvsfvs gdvgnapgfk epeesmstsp
     1621 qasiiameqq qlraelrlea lhqilvllsg meekgsisla gsrlssgfqs stlltsvrlq
     1681 flagcfglgt vghtggkges grlhhyqdgi raakrniqie iqvavhkiyq qlsatleral
     1741 qankhhieaq qrlllvtvfa lsvhyqpvdv slaistglln vlsqlcgtdt mlgqplqllp
     1801 ktgvsqlsta lkvastrllq ilaittgtya dklspkvvqs lldllcsqlk nllsqtgvlh
     1861 masfgegeqe dgeeeekkvd ssgetekkdf raalrkqhaa elhlgdflvf lrrvvsskai
     1921 qskmaspkwt evllniasqk cssgiplvgn lrtrllalhv leavlpaces gveddqmaqi
     1981 verlfsllsd cmwetpiaqa khaiqikeke qeiklqkqge leeedenlpi qevsfdpeka
     2041 qcclvengqi lthgsggkgy glastgvtsg cyqwkfyivk enrgnegtcv gvsrwpvhdf
     2101 nhrttsdmwl yraysgnlyh ngeqtltlss ftqgdfitcv ldmeartisf gkngeepkla
     2161 fedvdaaely pcvmfyssnp gekvkicdmq mrgtprdllp gdpicspvaa vlaeatiqli
     2221 rilhrtdrwt ycinkkmmer lhkikicike sgqklkksrs vqsreenemr eekeskeeek
     2281 gkhtrhglad lselqlrtlc ievwpvlavi ggvdaglrvg grcvhkqtgr hatllgvvke
     2341 gstsakvqwd eaeitisfpt fwspsdtply nlepceplpf dvarfrglta svlldltylt
     2401 gvhedmgkqs tkrhekkhrh eseekgdveq kpesesaldm rtgltsddvk sqsttsskse
     2461 neiasfsldp tlpsvesqhq itegkrknhe hmsknhdvaq seiravqlsy lylgamksls
     2521 allgcskyae lllipkvlae nghnsdcass pvvhedvemr aalqflmrhm vkravmrspi
     2581 kralgladle raqamiyklv vhglledqfg gkikqeidqq aeesdpaqqa qtpvttspsa
     2641 ssttsfmsss ledtttattp vtdtetvpas espgvmplsl lrqmfssypt ttvlptrraq
     2701 tppisslpts psdevgrrqs ltspdsqsar panrtalsdp ssrlstsppp paiavpllem
     2761 gfslrqiaka meatgargea daqnitvlam wmiehpghed eeepqsgsta dsrpgaavlg
     2821 sggksndpcy lqspgdipsa daaemeegfs espdnldhte naasgsgpsa rgrsavtrrh
     2881 kfdlaartll araaglyrsv qahrnqsrre gislqqdpga lydfnldeel eidlddeame
     2941 amfgqdltsd ndilgmwipe vldwptwhvc esedreevvv celcecsvvs fnqhmkrnhp
     3001 gcgrsanrqg yrsngsyvdg wfggecgsgn pyyllcgtcr ekylamktks kstsserykg
     3061 qapdligkqd svyeedwdml dvdedekltg eeefellagp lglndrrivp epvqfpdsdp
     3121 lgasvamvta tnsmeetlmq ielcfsgchg sveksssgri tlgeqaaala nphdrvvalr
     3181 rvtaaaqvll artmvmrals llsvsgsscs laagleslgl tdirtlvrlm claaagragl
     3241 stspsamast sersrgghsk ankpisclay lstavgclas napsaakllv qlctqnlisa
     3301 atgvnlttvd dsiqrkflps flrgiaeenk lvtspnfvvt qalvalladk gaklrpnydk
     3361 sevekkglia qlyahpsydp savgplelan alaacclssr lssqhrqwaa qqlvrtlaah
     3421 drdnqttlqt ladmggdlrk csfikleahq nrvmtcvwcn kkgllatsgn dgtirvwnvt
     3481 kkqyslqqtc vfnrlegdae eslgspsdps fspvswsisg kylagalekm vniwqvnggk
     3541 glvdiqphwv salawpeegp atawsgespe lllvgrmdgs lglievvdvs tmhrrelehc
     3601 yrkdvsvtci awfsedrpfa vgyfdgklll gtkeplekgg ivlidahkdt lismkwdptg
     3661 hilmtcaked svklwgsisg cwcclhslch psivngiawc rlpgkgsklq llmatgcqsg
     3721 lvcvwripqd ttqtnvtsae gwweqesncq dgyrkssgak cvyqlrghit pvrtvafssd
     3781 glalvsgglg glmniwslrd gsvlqtvvig sgaiqttvwi pevgvaacsn rskdvlvvnc
     3841 taewaaanhv latcrtalkq qgvlglnmap cmraflerlp mmlqeqyaye kphvvcgdql
     3901 vhspymqcla slavglhldq llcnppvpph hqnclpdpas wnpnewawle cfsttikaae
     3961 altngaqfpe sftvpdlepv pedelvflmd nskwingmde qimswatsrp edwhlggkcd
     4021 vylwgagrhg qlaeagrnvm vpaaapsfsq aqqvicgqnc tfviqangtv lacgegsygr
     4081 lgqgnsddlh vltvisalqg fvvtqlvtsc gsdghsmalt esgevfswgd gdygklghgn
     4141 sdrqrrprqi ealqgeevvq mscgfkhsav vtsdgklftf gngdygrlgl gntsnkklpe
     4201 rvtalegyqi gqvacglnht lavsadgsmv wafgdgdygk lglgnstaks spqkidvlcg
     4261 igikkvacgt qfsvaltkdg hvytfgqdrl iglpegrarn hnrpqqipvl agviiedvav
     4321 gaehtlalas ngdvyawgsn segqlglght nhvreptlvt glqgknvrqi sagrchsaaw
     4381 tappvpprap gvsvplqlgl pdtvppqyga lrevsihtvr arlrllyhfs dlmysswrll
     4441 nlspnnqnst shynagtwgi vqgqlrplla prvytlpmvr sigktmvqgk nygpqitvkr
     4501 istrgrkckp ifvqiarqvv klnasdlrlp srawkvklvg egaddaggvf ddtitemcqe
     4561 letgivdlli pspnataevg ynrdrflfnp sacldehlmq fkflgilmgv airtkkpldl
     4621 hlaplvwkql ccvpltledl eevdllyvqt lnsilhieds giteesfhem ipldsfvgqs
     4681 adgkmvpiip ggnsipltfs nrkeyverai eyrlhemdrq vaavregmsw ivpvpllsll
     4741 takqleqmvc gmpeisvevl kkvvryrevd eqhqlvqwfw htleefsnee rvlfmrfvsg
     4801 rsrlpantad isqrfqimkv drpydslpts qtcffqlrlp pyssqlvmae rlryainncr
     4861 sidmdnymls rnvdnaegsd tdy
//
LOCUS       XP_047289189            4883 aa            linear   PRI 05-AUG-2025
DEFINITION  putative E3 ubiquitin-protein ligase HERC1 isoform X18 [Homo
            sapiens].
ACCESSION   XP_047289189
VERSION     XP_047289189.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433233.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4883
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4883
                     /product="putative E3 ubiquitin-protein ligase HERC1
                     isoform X18"
                     /calculated_mol_wt=534409
     Region          374..703
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          683..733
                     /region_name="RCC1"
                     /note="Regulator of chromosome condensation (RCC1) repeat;
                     pfam00415"
                     /db_xref="CDD:395335"
     Region          2040..2197
                     /region_name="SPRY_HERC1"
                     /note="SPRY domain in HERC1; cd12881"
                     /db_xref="CDD:293939"
     Region          2753..2796
                     /region_name="UBA_HERC1"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC1 and similar proteins; cd14401"
                     /db_xref="CDD:270584"
     Region          <3409..3800
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          3454..3497
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3511..3546
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3551..3598
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3607..3642
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3651..3687
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3694..3725
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3772..3808
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          4021..4357
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          4495..4863
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4500,4541,4552,4619,4797,4827..4828,4831..4835,4855,
                     4862)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4647,4650..4651,4653..4654,4657,4665,4667,
                     4671..4672,4674,4683,4688,4705,4709)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4883
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /coded_by="XM_047433233.1:149..14800"
                     /db_xref="GeneID:8925"
                     /db_xref="HGNC:HGNC:4867"
                     /db_xref="MIM:605109"
ORIGIN      
        1 matmippvkl kwlehlnssw itedsesiat regvavlysk lvsnkevvpl pqqvlclkgp
       61 qlpdferesl ssdeqdhyld allssqlala kmvcsdspfa galrkrllvl qrvfyalsnk
      121 yhdkgkvkqq qhspesssgs advhsvserp rsstdaliem gvrtglsllf allrqswmmp
      181 vsgpglslcn dvihtaievv sslpplslan eskippmgld clsqvttflk gvtipnsgad
      241 tlgrrlasel llglaaqrgs lryllewiem algasavvht mekgkllssq egmisfdcfm
      301 tilmqmrrsl gssadrsqwr eptrtsdglc slyeaalclf eevcrmasdy srtcaspdsi
      361 qtgdapivse tcevyvwgsn sshqlvegtq ekilqpklap sfsdaqtiea gqyctfvist
      421 dgsvracgkg sygrlglgds nnqstlkklt fephrsikkv ssskgsdght lafttegevf
      481 swgdgdygkl ghgnsstqky pkliqgplqg kvvvcvsagy rhsaavtedg elytwgegdf
      541 grlghgdsns rniptlvkdi snvgevscgs shtialskdg rtvwsfgggd ngklghgdtn
      601 rvykpkviea lqgmfirkvc agsqsslalt stgqvyawgc gaclgcgsse atalrpklie
      661 elaatrivdv sigdshclal shdnevyawg nnsmgqcgqg nstgpitkpk kvsgldgiai
      721 qqisagtshs lawtalprdr qvvawhrpyc vdleestfsh lrsflerycd kinseipplp
      781 fpssrehhsf lklclkllsn hlalalaggv atsilgrqag plrnllfrlm dstvpdeiqe
      841 vvietlsvga tmllpplrer mellhsllpq gpdrweslsk gqrmqldiil tslqdhthva
      901 sllgysspsd aadlssvctg ygnlsdqpyg tqschpdthl aeilmktllr nlgfytdqaf
      961 geleknsdkf llgtsssens qpahlhellc slqkqllafc hinnisenss svallhkhlq
     1021 lllphatdiy srsanllkes pwngsvgekl rdviyvsaag smlcqivnsl lllpvsvarp
     1081 llsylldllp pldclnrllp aadlledqel qwplhggpel idpaglplpq paqswvwlvd
     1141 lertiallig rclggmlqgs pvspeeqdta ywmktplfsd gvemdtpqld kcmsclleva
     1201 lsgneeqkpf dyklrpeiav yvdlalgcsk eparslwism qdyavskdwd satlsnesll
     1261 dtvsrfvlaa llkhtnllsq acgesryqpg khlsevyrcv ykvrsrllac knleliqtrs
     1321 ssrdrwisen qdsadvdpqe hsftrtidee aemeeqaerd reeghpeped eeeerehevm
     1381 tagnlvfvlh vteifqcfls arevarsrdr drmnsgagsg araddpppqs qqerrvstdl
     1441 pegqdvytaa cnsvihrcal lilgvspvid elqkrreegq lqqpstsase ggglmtrses
     1501 ltaesrlvht spnyrliksr sesdlsqpes deegyalsgr rnvdldlaas hrkrgpmhsq
     1561 leslsdswar lkhsrdwlcn ssysfesdfd ltkslgvhtl ienvvsfvsg dvgnapgfke
     1621 peesmstspq asiiameqqq lraelrleal hqilvllsgm eekgsislag srlssgfqss
     1681 tlltsvrlqf lagcfglgtv ghtggkgesg rlhhyqdgir aakrniqiei qvavhkiyqq
     1741 lsatleralq ankhhieaqq rlllvtvfal svhyqpvdvs laistgllnv lsqlcgtdtm
     1801 lgqplqllpk tgvsqlstal kvastrllqi laittgtyad klspkvvqsl ldllcsqlkn
     1861 llsqtgvlhm asfgegeqed geeeekkvds sgetekkdfr aalrkqhaae lhlgdflvfl
     1921 rrvvsskaiq skmaspkwte vllniasqkc ssgiplvgnl rtrllalhvl eavlpacesg
     1981 veddqmaqiv erlfsllsdc mwetpiaqak haiqikekeq eiklqqgele eedenlpiqe
     2041 vsfdpekaqc clvengqilt hgsggkgygl astgvtsgcy qwkfyivken rgnegtcvgv
     2101 srwpvhdfnh rttsdmwlyr aysgnlyhng eqtltlssft qgdfitcvld meartisfgk
     2161 ngeepklafe dvdaaelypc vmfyssnpge kvkicdmqmr gtprdllpgd picspvaavl
     2221 aeatiqliri lhrtdrwtyc inkkmmerlh kikicikesg qklkksrsvq sreenemree
     2281 keskeeekgk htrhgladls elqlrtlcie vwpvlavigg vdaglrvggr cvhkqtgrha
     2341 tllgvvkegs tsakvqwdea eitisdtply nlepceplpf dvarfrglta svlldltylt
     2401 gvhedmgkqs tkrhekkhrh eseekgdveq kpesesaldm rtgltsddvk sqsttsskse
     2461 neiasfsldp tlpsvesqhq itegkrknhe hmsknhdvaq seiravqlsy lylgamksls
     2521 allgcskyae lllipkvlae nghnsdcass pvvhedvemr aalqflmrhm vkravmrspi
     2581 kralgladle raqamiyklv vhglledqfg gkikqeidqq aeesdpaqqa qtpvttspsa
     2641 ssttsfmsss ledtttattp vtdtetvpas espgvmplsl lrqmfssypt ttvlptrraq
     2701 tppisslpts psdevgrrqs ltspdsqsar panrtalsdp ssrlstsppp paiavpllem
     2761 gfslrqiaka meatgargea daqnitvlam wmiehpghed eeepqsgsta dsrpgaavlg
     2821 sggksndpcy lqspgdipsa daaemeegfs espdnldhte naasgsgpsa rgrsavtrrh
     2881 kfdlaartll araaglyrsv qahrnqsrre gislqqdpga lydfnldeel eidlddeame
     2941 amfgqdltsd ndilgmwipe vldwptwhvc esedreevvv celcecsvvs fnqhmkrnhp
     3001 gcgrsanrqg yrsngsyvdg wfggecgsgn pyyllcgtcr ekylamktks kstsserykg
     3061 qapdligkqd svyeedwdml dvdedekltg eeefellagp lglndrrivp epvqfpdsdp
     3121 lgasvamvta tnsmeetlmq ielcfsgchg sveksssgri tlgeqaaala nphdrvvalr
     3181 rvtaaaqvll artmvmrals llsvsgsscs laagleslgl tdirtlvrlm claaagragl
     3241 stspsamast sersrgghsk ankpisclay lstavgclas napsaakllv qlctqnlisa
     3301 atgvnlttvd dsiqrkflps flrgiaeenk lvtspnfvvt qalvalladk gaklrpnydk
     3361 sevekkglia qlyahpsydp savgplelan alaacclssr lssqhrqwaa qqlvrtlaah
     3421 drdnqttlqt ladmggdlrk csfikleahq nrvmtcvwcn kkgllatsgn dgtirvwnvt
     3481 kkqyslqqtc vfnrlegdae eslgspsdps fspvswsisg kylagalekm vniwqvnggk
     3541 glvdiqphwv salawpeegp atawsgespe lllvgrmdgs lglievvdvs tmhrrelehc
     3601 yrkdvsvtci awfsedrpfa vgyfdgklll gtkeplekgg ivlidahkdt lismkwdptg
     3661 hilmtcaked svklwgsisg cwcclhslch psivngiawc rlpgkgsklq llmatgcqsg
     3721 lvcvwripqd ttqtnvtsae gwweqesncq dgyrkssgak cvyqlrghit pvrtvafssd
     3781 glalvsgglg glmniwslrd gsvlqtvvig sgaiqttvwi pevgvaacsn rskdvlvvnc
     3841 taewaaanhv latcrtalkq qgvlglnmap cmraflerlp mmlqeqyaye kphvvcgdql
     3901 vhspymqcla slavglhldq llcnppvpph hqnclpdpas wnpnewawle cfsttikaae
     3961 altngaqfpe sftvpdlepv pedelvflmd nskwingmde qimswatsrp edwhlggkcd
     4021 vylwgagrhg qlaeagrnvm vpaaapsfsq aqqvicgqnc tfviqangtv lacgegsygr
     4081 lgqgnsddlh vltvisalqg fvvtqlvtsc gsdghsmalt esgevfswgd gdygklghgn
     4141 sdrqrrprqi ealqgeevvq mscgfkhsav vtsdgklftf gngdygrlgl gntsnkklpe
     4201 rvtalegyqi gqvacglnht lavsadgsmv wafgdgdygk lglgnstaks spqkidvlcg
     4261 igikkvacgt qfsvaltkdg hvytfgqdrl iglpegrarn hnrpqqipvl agviiedvav
     4321 gaehtlalas ngdvyawgsn segqlglght nhvreptlvt glqgknvrqi sagrchsaaw
     4381 tappvpprap gvsvplqlgl pdtvppqyga lrevsihtvr arlrllyhfs dlmysswrll
     4441 nlspnnqnst shynagtwgi vqgqlrplla prvytlpmvr sigktmvqgk nygpqitvkr
     4501 istrgrkckp ifvqiarqvv klnasdlrlp srawkvklvg egaddaggvf ddtitemcqe
     4561 letgivdlli pspnataevg ynrdrflfnp sacldehlmq fkflgilmgv airtkkpldl
     4621 hlaplvwkql ccvpltledl eevdllyvqt lnsilhieds giteesfhem ipldsfvgqs
     4681 adgkmvpiip ggnsipltfs nrkeyverai eyrlhemdrq vaavregmsw ivpvpllsll
     4741 takqleqmvc gmpeisvevl kkvvryrevd eqhqlvqwfw htleefsnee rvlfmrfvsg
     4801 rsrlpantad isqrfqimkv drpydslpts qtcffqlrlp pyssqlvmae rlryainncr
     4861 sidmdnymls rnvdnaegsd tdy
//
LOCUS       XP_047289190            4882 aa            linear   PRI 05-AUG-2025
DEFINITION  putative E3 ubiquitin-protein ligase HERC1 isoform X19 [Homo
            sapiens].
ACCESSION   XP_047289190
VERSION     XP_047289190.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433234.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4882
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4882
                     /product="putative E3 ubiquitin-protein ligase HERC1
                     isoform X19"
                     /calculated_mol_wt=534335
     Region          374..703
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          683..733
                     /region_name="RCC1"
                     /note="Regulator of chromosome condensation (RCC1) repeat;
                     pfam00415"
                     /db_xref="CDD:395335"
     Region          2031..2188
                     /region_name="SPRY_HERC1"
                     /note="SPRY domain in HERC1; cd12881"
                     /db_xref="CDD:293939"
     Region          2752..2795
                     /region_name="UBA_HERC1"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC1 and similar proteins; cd14401"
                     /db_xref="CDD:270584"
     Region          <3408..3799
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          3453..3496
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3510..3545
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3550..3597
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3606..3641
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3650..3686
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3693..3724
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3771..3807
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          4020..4356
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          4494..4862
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4499,4540,4551,4618,4796,4826..4827,4830..4834,4854,
                     4861)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4646,4649..4650,4652..4653,4656,4664,4666,
                     4670..4671,4673,4682,4687,4704,4708)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4882
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /coded_by="XM_047433234.1:149..14797"
                     /db_xref="GeneID:8925"
                     /db_xref="HGNC:HGNC:4867"
                     /db_xref="MIM:605109"
ORIGIN      
        1 matmippvkl kwlehlnssw itedsesiat regvavlysk lvsnkevvpl pqqvlclkgp
       61 qlpdferesl ssdeqdhyld allssqlala kmvcsdspfa galrkrllvl qrvfyalsnk
      121 yhdkgkvkqq qhspesssgs advhsvserp rsstdaliem gvrtglsllf allrqswmmp
      181 vsgpglslcn dvihtaievv sslpplslan eskippmgld clsqvttflk gvtipnsgad
      241 tlgrrlasel llglaaqrgs lryllewiem algasavvht mekgkllssq egmisfdcfm
      301 tilmqmrrsl gssadrsqwr eptrtsdglc slyeaalclf eevcrmasdy srtcaspdsi
      361 qtgdapivse tcevyvwgsn sshqlvegtq ekilqpklap sfsdaqtiea gqyctfvist
      421 dgsvracgkg sygrlglgds nnqstlkklt fephrsikkv ssskgsdght lafttegevf
      481 swgdgdygkl ghgnsstqky pkliqgplqg kvvvcvsagy rhsaavtedg elytwgegdf
      541 grlghgdsns rniptlvkdi snvgevscgs shtialskdg rtvwsfgggd ngklghgdtn
      601 rvykpkviea lqgmfirkvc agsqsslalt stgqvyawgc gaclgcgsse atalrpklie
      661 elaatrivdv sigdshclal shdnevyawg nnsmgqcgqg nstgpitkpk kvsgldgiai
      721 qqisagtshs lawtalprdr qvvawhrpyc vdleestfsh lrsflerycd kinseipplp
      781 fpssrehhsf lklclkllsn hlalalaggv atsilgrqag plrnllfrlm dstvpdeiqe
      841 vvietlsvga tmllpplrer mellhsllpq gpdrweslsk gqrmqldiil tslqdhthva
      901 sllgysspsd aadlssvctg ygnlsdqpyg tqschpdthl aeilmktllr nlgfytdqaf
      961 geleknsdkf llgtsssens qpahlhellc slqkqllafc hinnisenss svallhkhlq
     1021 lllphatdiy srsanllkes pwngsvgekl rdviyvsaag smlcqivnsl lllpvsvarp
     1081 llsylldllp pldclnrllp aadlledqel qwplhggpel idpaglplpq paqswvwlvd
     1141 lertiallig rclggmlqgs pvspeeqdta ywmktplfsd gvemdtpqld kcmsclleva
     1201 lsgneeqkpf dyklrpeiav yvdlalgcsk eparslwism qdyavskdwd satlsnesll
     1261 dtvsrfvlaa llkhtnllsq acgesryqpg khlsevyrcv ykvrsrllac knleliqtrs
     1321 ssrdrwisen qdsadvdpqe hsftrtidee aemeeqaerd reeghpeped eeeerehevm
     1381 tagkifqcfl sarevarsrd rdrmnsgags garaddpppq sqqerrvstd lpegqdvyta
     1441 acnsvihrca llilgvspvi delqkrreeg qlqqpstsas eggglmtrse sltaesrlvh
     1501 tspnyrliks rsesdlsqpe sdeegyalsg rrnvdldlaa shrkrgpmhs qleslsdswa
     1561 rlkhsrdwlc nssysfesdf dltkslgvht lienvvsfvs gdvgnapgfk epeesmstsp
     1621 qasiiameqq qlraelrlea lhqilvllsg meekgsisla gsrlssgfqs stlltsvrlq
     1681 flagcfglgt vghtggkges grlhhyqdgi raakrniqie iqvavhkiyq qlsatleral
     1741 qankhhieaq qrlllvtvfa lsvhyqpvdv slaistglln vlsqlcgtdt mlgqplqllp
     1801 ktgvsqlsta lkvastrllq ilaittgtya dklspkvvqs lldllcsqlk nllsqtgvlh
     1861 masfgegeqe dgeeeekkvd ssgetekkdf raalrkqhaa elhlgdflvf lrrvvsskai
     1921 qskmaspkwt evllniasqk cssgiplvgn lrtrllalhv leavlpaces gveddqmaqi
     1981 verlfsllsd cmwetpiaqa khaiqikeke qeiklqqgel eeedenlpiq evsfdpekaq
     2041 cclvengqil thgsggkgyg lastgvtsgc yqwkfyivke nrgnegtcvg vsrwpvhdfn
     2101 hrttsdmwly raysgnlyhn geqtltlssf tqgdfitcvl dmeartisfg kngeepklaf
     2161 edvdaaelyp cvmfyssnpg ekvkicdmqm rgtprdllpg dpicspvaav laeatiqlir
     2221 ilhrtdrwty cinkkmmerl hkikicikes gqklkksrsv qsreenemre ekeskeeekg
     2281 khtrhgladl selqlrtlci evwpvlavig gvdaglrvgg rcvhkqtgrh atllgvvkeg
     2341 stsakvqwde aeitisfptf wspsdtplyn lepceplpfd varfrgltas vlldltyltg
     2401 vhedmgkqst krhekkhrhe seekgdveqk pesesaldmr tgltsddvks qsttssksen
     2461 eiasfsldpt lpsvesqhqi tegkrknheh msknhdvaqs eiravqlsyl ylgamkslsa
     2521 llgcskyael llipkvlaen ghnsdcassp vvhedvemra alqflmrhmv kravmrspik
     2581 ralgladler aqamiyklvv hglledqfgg kikqeidqqa eesdpaqqaq tpvttspsas
     2641 sttsfmsssl edtttattpv tdtetvpase spgvmplsll rqmfssyptt tvlptrraqt
     2701 ppisslptsp sdevgrrqsl tspdsqsarp anrtalsdps srlstspppp aiavpllemg
     2761 fslrqiakam eatgargead aqnitvlamw miehpghede eepqsgstad srpgaavlgs
     2821 ggksndpcyl qspgdipsad aaemeegfse spdnldhten aasgsgpsar grsavtrrhk
     2881 fdlaartlla raaglyrsvq ahrnqsrreg islqqdpgal ydfnldeele idlddeamea
     2941 mfgqdltsdn dilgmwipev ldwptwhvce sedreevvvc elcecsvvsf nqhmkrnhpg
     3001 cgrsanrqgy rsngsyvdgw fggecgsgnp yyllcgtcre kylamktksk stsserykgq
     3061 apdligkqds vyeedwdmld vdedekltge eefellagpl glndrrivpe pvqfpdsdpl
     3121 gasvamvtat nsmeetlmqi elcfsgchgs veksssgrit lgeqaaalan phdrvvalrr
     3181 vtaaaqvlla rtmvmralsl lsvsgsscsl aagleslglt dirtlvrlmc laaagragls
     3241 tspsamasts ersrgghska nkpisclayl stavgclasn apsaakllvq lctqnlisaa
     3301 tgvnlttvdd siqrkflpsf lrgiaeenkl vtspnfvvtq alvalladkg aklrpnydks
     3361 evekkgliaq lyahpsydps avgplelana laacclssrl ssqhrqwaaq qlvrtlaahd
     3421 rdnqttlqtl admggdlrkc sfikleahqn rvmtcvwcnk kgllatsgnd gtirvwnvtk
     3481 kqyslqqtcv fnrlegdaee slgspsdpsf spvswsisgk ylagalekmv niwqvnggkg
     3541 lvdiqphwvs alawpeegpa tawsgespel llvgrmdgsl glievvdvst mhrrelehcy
     3601 rkdvsvtcia wfsedrpfav gyfdgklllg tkeplekggi vlidahkdtl ismkwdptgh
     3661 ilmtcakeds vklwgsisgc wcclhslchp sivngiawcr lpgkgsklql lmatgcqsgl
     3721 vcvwripqdt tqtnvtsaeg wweqesncqd gyrkssgakc vyqlrghitp vrtvafssdg
     3781 lalvsgglgg lmniwslrdg svlqtvvigs gaiqttvwip evgvaacsnr skdvlvvnct
     3841 aewaaanhvl atcrtalkqq gvlglnmapc mraflerlpm mlqeqyayek phvvcgdqlv
     3901 hspymqclas lavglhldql lcnppvpphh qnclpdpasw npnewawlec fsttikaaea
     3961 ltngaqfpes ftvpdlepvp edelvflmdn skwingmdeq imswatsrpe dwhlggkcdv
     4021 ylwgagrhgq laeagrnvmv paaapsfsqa qqvicgqnct fviqangtvl acgegsygrl
     4081 gqgnsddlhv ltvisalqgf vvtqlvtscg sdghsmalte sgevfswgdg dygklghgns
     4141 drqrrprqie alqgeevvqm scgfkhsavv tsdgklftfg ngdygrlglg ntsnkklper
     4201 vtalegyqig qvacglnhtl avsadgsmvw afgdgdygkl glgnstakss pqkidvlcgi
     4261 gikkvacgtq fsvaltkdgh vytfgqdrli glpegrarnh nrpqqipvla gviiedvavg
     4321 aehtlalasn gdvyawgsns egqlglghtn hvreptlvtg lqgknvrqis agrchsaawt
     4381 appvpprapg vsvplqlglp dtvppqygal revsihtvra rlrllyhfsd lmysswrlln
     4441 lspnnqnsts hynagtwgiv qgqlrpllap rvytlpmvrs igktmvqgkn ygpqitvkri
     4501 strgrkckpi fvqiarqvvk lnasdlrlps rawkvklvge gaddaggvfd dtitemcqel
     4561 etgivdllip spnataevgy nrdrflfnps acldehlmqf kflgilmgva irtkkpldlh
     4621 laplvwkqlc cvpltledle evdllyvqtl nsilhiedsg iteesfhemi pldsfvgqsa
     4681 dgkmvpiipg gnsipltfsn rkeyveraie yrlhemdrqv aavregmswi vpvpllsllt
     4741 akqleqmvcg mpeisvevlk kvvryrevde qhqlvqwfwh tleefsneer vlfmrfvsgr
     4801 srlpantadi sqrfqimkvd rpydslptsq tcffqlrlpp yssqlvmaer lryainncrs
     4861 idmdnymlsr nvdnaegsdt dy
//
LOCUS       XP_047289191            4882 aa            linear   PRI 05-AUG-2025
DEFINITION  putative E3 ubiquitin-protein ligase HERC1 isoform X19 [Homo
            sapiens].
ACCESSION   XP_047289191
VERSION     XP_047289191.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433235.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4882
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4882
                     /product="putative E3 ubiquitin-protein ligase HERC1
                     isoform X19"
                     /calculated_mol_wt=534335
     Region          374..703
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          683..733
                     /region_name="RCC1"
                     /note="Regulator of chromosome condensation (RCC1) repeat;
                     pfam00415"
                     /db_xref="CDD:395335"
     Region          2031..2188
                     /region_name="SPRY_HERC1"
                     /note="SPRY domain in HERC1; cd12881"
                     /db_xref="CDD:293939"
     Region          2752..2795
                     /region_name="UBA_HERC1"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC1 and similar proteins; cd14401"
                     /db_xref="CDD:270584"
     Region          <3408..3799
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          3453..3496
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3510..3545
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3550..3597
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3606..3641
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3650..3686
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3693..3724
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3771..3807
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          4020..4356
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          4494..4862
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4499,4540,4551,4618,4796,4826..4827,4830..4834,4854,
                     4861)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4646,4649..4650,4652..4653,4656,4664,4666,
                     4670..4671,4673,4682,4687,4704,4708)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4882
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /coded_by="XM_047433235.1:154..14802"
                     /db_xref="GeneID:8925"
                     /db_xref="HGNC:HGNC:4867"
                     /db_xref="MIM:605109"
ORIGIN      
        1 matmippvkl kwlehlnssw itedsesiat regvavlysk lvsnkevvpl pqqvlclkgp
       61 qlpdferesl ssdeqdhyld allssqlala kmvcsdspfa galrkrllvl qrvfyalsnk
      121 yhdkgkvkqq qhspesssgs advhsvserp rsstdaliem gvrtglsllf allrqswmmp
      181 vsgpglslcn dvihtaievv sslpplslan eskippmgld clsqvttflk gvtipnsgad
      241 tlgrrlasel llglaaqrgs lryllewiem algasavvht mekgkllssq egmisfdcfm
      301 tilmqmrrsl gssadrsqwr eptrtsdglc slyeaalclf eevcrmasdy srtcaspdsi
      361 qtgdapivse tcevyvwgsn sshqlvegtq ekilqpklap sfsdaqtiea gqyctfvist
      421 dgsvracgkg sygrlglgds nnqstlkklt fephrsikkv ssskgsdght lafttegevf
      481 swgdgdygkl ghgnsstqky pkliqgplqg kvvvcvsagy rhsaavtedg elytwgegdf
      541 grlghgdsns rniptlvkdi snvgevscgs shtialskdg rtvwsfgggd ngklghgdtn
      601 rvykpkviea lqgmfirkvc agsqsslalt stgqvyawgc gaclgcgsse atalrpklie
      661 elaatrivdv sigdshclal shdnevyawg nnsmgqcgqg nstgpitkpk kvsgldgiai
      721 qqisagtshs lawtalprdr qvvawhrpyc vdleestfsh lrsflerycd kinseipplp
      781 fpssrehhsf lklclkllsn hlalalaggv atsilgrqag plrnllfrlm dstvpdeiqe
      841 vvietlsvga tmllpplrer mellhsllpq gpdrweslsk gqrmqldiil tslqdhthva
      901 sllgysspsd aadlssvctg ygnlsdqpyg tqschpdthl aeilmktllr nlgfytdqaf
      961 geleknsdkf llgtsssens qpahlhellc slqkqllafc hinnisenss svallhkhlq
     1021 lllphatdiy srsanllkes pwngsvgekl rdviyvsaag smlcqivnsl lllpvsvarp
     1081 llsylldllp pldclnrllp aadlledqel qwplhggpel idpaglplpq paqswvwlvd
     1141 lertiallig rclggmlqgs pvspeeqdta ywmktplfsd gvemdtpqld kcmsclleva
     1201 lsgneeqkpf dyklrpeiav yvdlalgcsk eparslwism qdyavskdwd satlsnesll
     1261 dtvsrfvlaa llkhtnllsq acgesryqpg khlsevyrcv ykvrsrllac knleliqtrs
     1321 ssrdrwisen qdsadvdpqe hsftrtidee aemeeqaerd reeghpeped eeeerehevm
     1381 tagkifqcfl sarevarsrd rdrmnsgags garaddpppq sqqerrvstd lpegqdvyta
     1441 acnsvihrca llilgvspvi delqkrreeg qlqqpstsas eggglmtrse sltaesrlvh
     1501 tspnyrliks rsesdlsqpe sdeegyalsg rrnvdldlaa shrkrgpmhs qleslsdswa
     1561 rlkhsrdwlc nssysfesdf dltkslgvht lienvvsfvs gdvgnapgfk epeesmstsp
     1621 qasiiameqq qlraelrlea lhqilvllsg meekgsisla gsrlssgfqs stlltsvrlq
     1681 flagcfglgt vghtggkges grlhhyqdgi raakrniqie iqvavhkiyq qlsatleral
     1741 qankhhieaq qrlllvtvfa lsvhyqpvdv slaistglln vlsqlcgtdt mlgqplqllp
     1801 ktgvsqlsta lkvastrllq ilaittgtya dklspkvvqs lldllcsqlk nllsqtgvlh
     1861 masfgegeqe dgeeeekkvd ssgetekkdf raalrkqhaa elhlgdflvf lrrvvsskai
     1921 qskmaspkwt evllniasqk cssgiplvgn lrtrllalhv leavlpaces gveddqmaqi
     1981 verlfsllsd cmwetpiaqa khaiqikeke qeiklqqgel eeedenlpiq evsfdpekaq
     2041 cclvengqil thgsggkgyg lastgvtsgc yqwkfyivke nrgnegtcvg vsrwpvhdfn
     2101 hrttsdmwly raysgnlyhn geqtltlssf tqgdfitcvl dmeartisfg kngeepklaf
     2161 edvdaaelyp cvmfyssnpg ekvkicdmqm rgtprdllpg dpicspvaav laeatiqlir
     2221 ilhrtdrwty cinkkmmerl hkikicikes gqklkksrsv qsreenemre ekeskeeekg
     2281 khtrhgladl selqlrtlci evwpvlavig gvdaglrvgg rcvhkqtgrh atllgvvkeg
     2341 stsakvqwde aeitisfptf wspsdtplyn lepceplpfd varfrgltas vlldltyltg
     2401 vhedmgkqst krhekkhrhe seekgdveqk pesesaldmr tgltsddvks qsttssksen
     2461 eiasfsldpt lpsvesqhqi tegkrknheh msknhdvaqs eiravqlsyl ylgamkslsa
     2521 llgcskyael llipkvlaen ghnsdcassp vvhedvemra alqflmrhmv kravmrspik
     2581 ralgladler aqamiyklvv hglledqfgg kikqeidqqa eesdpaqqaq tpvttspsas
     2641 sttsfmsssl edtttattpv tdtetvpase spgvmplsll rqmfssyptt tvlptrraqt
     2701 ppisslptsp sdevgrrqsl tspdsqsarp anrtalsdps srlstspppp aiavpllemg
     2761 fslrqiakam eatgargead aqnitvlamw miehpghede eepqsgstad srpgaavlgs
     2821 ggksndpcyl qspgdipsad aaemeegfse spdnldhten aasgsgpsar grsavtrrhk
     2881 fdlaartlla raaglyrsvq ahrnqsrreg islqqdpgal ydfnldeele idlddeamea
     2941 mfgqdltsdn dilgmwipev ldwptwhvce sedreevvvc elcecsvvsf nqhmkrnhpg
     3001 cgrsanrqgy rsngsyvdgw fggecgsgnp yyllcgtcre kylamktksk stsserykgq
     3061 apdligkqds vyeedwdmld vdedekltge eefellagpl glndrrivpe pvqfpdsdpl
     3121 gasvamvtat nsmeetlmqi elcfsgchgs veksssgrit lgeqaaalan phdrvvalrr
     3181 vtaaaqvlla rtmvmralsl lsvsgsscsl aagleslglt dirtlvrlmc laaagragls
     3241 tspsamasts ersrgghska nkpisclayl stavgclasn apsaakllvq lctqnlisaa
     3301 tgvnlttvdd siqrkflpsf lrgiaeenkl vtspnfvvtq alvalladkg aklrpnydks
     3361 evekkgliaq lyahpsydps avgplelana laacclssrl ssqhrqwaaq qlvrtlaahd
     3421 rdnqttlqtl admggdlrkc sfikleahqn rvmtcvwcnk kgllatsgnd gtirvwnvtk
     3481 kqyslqqtcv fnrlegdaee slgspsdpsf spvswsisgk ylagalekmv niwqvnggkg
     3541 lvdiqphwvs alawpeegpa tawsgespel llvgrmdgsl glievvdvst mhrrelehcy
     3601 rkdvsvtcia wfsedrpfav gyfdgklllg tkeplekggi vlidahkdtl ismkwdptgh
     3661 ilmtcakeds vklwgsisgc wcclhslchp sivngiawcr lpgkgsklql lmatgcqsgl
     3721 vcvwripqdt tqtnvtsaeg wweqesncqd gyrkssgakc vyqlrghitp vrtvafssdg
     3781 lalvsgglgg lmniwslrdg svlqtvvigs gaiqttvwip evgvaacsnr skdvlvvnct
     3841 aewaaanhvl atcrtalkqq gvlglnmapc mraflerlpm mlqeqyayek phvvcgdqlv
     3901 hspymqclas lavglhldql lcnppvpphh qnclpdpasw npnewawlec fsttikaaea
     3961 ltngaqfpes ftvpdlepvp edelvflmdn skwingmdeq imswatsrpe dwhlggkcdv
     4021 ylwgagrhgq laeagrnvmv paaapsfsqa qqvicgqnct fviqangtvl acgegsygrl
     4081 gqgnsddlhv ltvisalqgf vvtqlvtscg sdghsmalte sgevfswgdg dygklghgns
     4141 drqrrprqie alqgeevvqm scgfkhsavv tsdgklftfg ngdygrlglg ntsnkklper
     4201 vtalegyqig qvacglnhtl avsadgsmvw afgdgdygkl glgnstakss pqkidvlcgi
     4261 gikkvacgtq fsvaltkdgh vytfgqdrli glpegrarnh nrpqqipvla gviiedvavg
     4321 aehtlalasn gdvyawgsns egqlglghtn hvreptlvtg lqgknvrqis agrchsaawt
     4381 appvpprapg vsvplqlglp dtvppqygal revsihtvra rlrllyhfsd lmysswrlln
     4441 lspnnqnsts hynagtwgiv qgqlrpllap rvytlpmvrs igktmvqgkn ygpqitvkri
     4501 strgrkckpi fvqiarqvvk lnasdlrlps rawkvklvge gaddaggvfd dtitemcqel
     4561 etgivdllip spnataevgy nrdrflfnps acldehlmqf kflgilmgva irtkkpldlh
     4621 laplvwkqlc cvpltledle evdllyvqtl nsilhiedsg iteesfhemi pldsfvgqsa
     4681 dgkmvpiipg gnsipltfsn rkeyveraie yrlhemdrqv aavregmswi vpvpllsllt
     4741 akqleqmvcg mpeisvevlk kvvryrevde qhqlvqwfwh tleefsneer vlfmrfvsgr
     4801 srlpantadi sqrfqimkvd rpydslptsq tcffqlrlpp yssqlvmaer lryainncrs
     4861 idmdnymlsr nvdnaegsdt dy
//
LOCUS       XP_047289192            4882 aa            linear   PRI 05-AUG-2025
DEFINITION  putative E3 ubiquitin-protein ligase HERC1 isoform X19 [Homo
            sapiens].
ACCESSION   XP_047289192
VERSION     XP_047289192.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433236.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4882
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4882
                     /product="putative E3 ubiquitin-protein ligase HERC1
                     isoform X19"
                     /calculated_mol_wt=534335
     Region          374..703
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          683..733
                     /region_name="RCC1"
                     /note="Regulator of chromosome condensation (RCC1) repeat;
                     pfam00415"
                     /db_xref="CDD:395335"
     Region          2031..2188
                     /region_name="SPRY_HERC1"
                     /note="SPRY domain in HERC1; cd12881"
                     /db_xref="CDD:293939"
     Region          2752..2795
                     /region_name="UBA_HERC1"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC1 and similar proteins; cd14401"
                     /db_xref="CDD:270584"
     Region          <3408..3799
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          3453..3496
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3510..3545
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3550..3597
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3606..3641
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3650..3686
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3693..3724
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3771..3807
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          4020..4356
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          4494..4862
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4499,4540,4551,4618,4796,4826..4827,4830..4834,4854,
                     4861)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4646,4649..4650,4652..4653,4656,4664,4666,
                     4670..4671,4673,4682,4687,4704,4708)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4882
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /coded_by="XM_047433236.1:474..15122"
                     /db_xref="GeneID:8925"
                     /db_xref="HGNC:HGNC:4867"
                     /db_xref="MIM:605109"
ORIGIN      
        1 matmippvkl kwlehlnssw itedsesiat regvavlysk lvsnkevvpl pqqvlclkgp
       61 qlpdferesl ssdeqdhyld allssqlala kmvcsdspfa galrkrllvl qrvfyalsnk
      121 yhdkgkvkqq qhspesssgs advhsvserp rsstdaliem gvrtglsllf allrqswmmp
      181 vsgpglslcn dvihtaievv sslpplslan eskippmgld clsqvttflk gvtipnsgad
      241 tlgrrlasel llglaaqrgs lryllewiem algasavvht mekgkllssq egmisfdcfm
      301 tilmqmrrsl gssadrsqwr eptrtsdglc slyeaalclf eevcrmasdy srtcaspdsi
      361 qtgdapivse tcevyvwgsn sshqlvegtq ekilqpklap sfsdaqtiea gqyctfvist
      421 dgsvracgkg sygrlglgds nnqstlkklt fephrsikkv ssskgsdght lafttegevf
      481 swgdgdygkl ghgnsstqky pkliqgplqg kvvvcvsagy rhsaavtedg elytwgegdf
      541 grlghgdsns rniptlvkdi snvgevscgs shtialskdg rtvwsfgggd ngklghgdtn
      601 rvykpkviea lqgmfirkvc agsqsslalt stgqvyawgc gaclgcgsse atalrpklie
      661 elaatrivdv sigdshclal shdnevyawg nnsmgqcgqg nstgpitkpk kvsgldgiai
      721 qqisagtshs lawtalprdr qvvawhrpyc vdleestfsh lrsflerycd kinseipplp
      781 fpssrehhsf lklclkllsn hlalalaggv atsilgrqag plrnllfrlm dstvpdeiqe
      841 vvietlsvga tmllpplrer mellhsllpq gpdrweslsk gqrmqldiil tslqdhthva
      901 sllgysspsd aadlssvctg ygnlsdqpyg tqschpdthl aeilmktllr nlgfytdqaf
      961 geleknsdkf llgtsssens qpahlhellc slqkqllafc hinnisenss svallhkhlq
     1021 lllphatdiy srsanllkes pwngsvgekl rdviyvsaag smlcqivnsl lllpvsvarp
     1081 llsylldllp pldclnrllp aadlledqel qwplhggpel idpaglplpq paqswvwlvd
     1141 lertiallig rclggmlqgs pvspeeqdta ywmktplfsd gvemdtpqld kcmsclleva
     1201 lsgneeqkpf dyklrpeiav yvdlalgcsk eparslwism qdyavskdwd satlsnesll
     1261 dtvsrfvlaa llkhtnllsq acgesryqpg khlsevyrcv ykvrsrllac knleliqtrs
     1321 ssrdrwisen qdsadvdpqe hsftrtidee aemeeqaerd reeghpeped eeeerehevm
     1381 tagkifqcfl sarevarsrd rdrmnsgags garaddpppq sqqerrvstd lpegqdvyta
     1441 acnsvihrca llilgvspvi delqkrreeg qlqqpstsas eggglmtrse sltaesrlvh
     1501 tspnyrliks rsesdlsqpe sdeegyalsg rrnvdldlaa shrkrgpmhs qleslsdswa
     1561 rlkhsrdwlc nssysfesdf dltkslgvht lienvvsfvs gdvgnapgfk epeesmstsp
     1621 qasiiameqq qlraelrlea lhqilvllsg meekgsisla gsrlssgfqs stlltsvrlq
     1681 flagcfglgt vghtggkges grlhhyqdgi raakrniqie iqvavhkiyq qlsatleral
     1741 qankhhieaq qrlllvtvfa lsvhyqpvdv slaistglln vlsqlcgtdt mlgqplqllp
     1801 ktgvsqlsta lkvastrllq ilaittgtya dklspkvvqs lldllcsqlk nllsqtgvlh
     1861 masfgegeqe dgeeeekkvd ssgetekkdf raalrkqhaa elhlgdflvf lrrvvsskai
     1921 qskmaspkwt evllniasqk cssgiplvgn lrtrllalhv leavlpaces gveddqmaqi
     1981 verlfsllsd cmwetpiaqa khaiqikeke qeiklqqgel eeedenlpiq evsfdpekaq
     2041 cclvengqil thgsggkgyg lastgvtsgc yqwkfyivke nrgnegtcvg vsrwpvhdfn
     2101 hrttsdmwly raysgnlyhn geqtltlssf tqgdfitcvl dmeartisfg kngeepklaf
     2161 edvdaaelyp cvmfyssnpg ekvkicdmqm rgtprdllpg dpicspvaav laeatiqlir
     2221 ilhrtdrwty cinkkmmerl hkikicikes gqklkksrsv qsreenemre ekeskeeekg
     2281 khtrhgladl selqlrtlci evwpvlavig gvdaglrvgg rcvhkqtgrh atllgvvkeg
     2341 stsakvqwde aeitisfptf wspsdtplyn lepceplpfd varfrgltas vlldltyltg
     2401 vhedmgkqst krhekkhrhe seekgdveqk pesesaldmr tgltsddvks qsttssksen
     2461 eiasfsldpt lpsvesqhqi tegkrknheh msknhdvaqs eiravqlsyl ylgamkslsa
     2521 llgcskyael llipkvlaen ghnsdcassp vvhedvemra alqflmrhmv kravmrspik
     2581 ralgladler aqamiyklvv hglledqfgg kikqeidqqa eesdpaqqaq tpvttspsas
     2641 sttsfmsssl edtttattpv tdtetvpase spgvmplsll rqmfssyptt tvlptrraqt
     2701 ppisslptsp sdevgrrqsl tspdsqsarp anrtalsdps srlstspppp aiavpllemg
     2761 fslrqiakam eatgargead aqnitvlamw miehpghede eepqsgstad srpgaavlgs
     2821 ggksndpcyl qspgdipsad aaemeegfse spdnldhten aasgsgpsar grsavtrrhk
     2881 fdlaartlla raaglyrsvq ahrnqsrreg islqqdpgal ydfnldeele idlddeamea
     2941 mfgqdltsdn dilgmwipev ldwptwhvce sedreevvvc elcecsvvsf nqhmkrnhpg
     3001 cgrsanrqgy rsngsyvdgw fggecgsgnp yyllcgtcre kylamktksk stsserykgq
     3061 apdligkqds vyeedwdmld vdedekltge eefellagpl glndrrivpe pvqfpdsdpl
     3121 gasvamvtat nsmeetlmqi elcfsgchgs veksssgrit lgeqaaalan phdrvvalrr
     3181 vtaaaqvlla rtmvmralsl lsvsgsscsl aagleslglt dirtlvrlmc laaagragls
     3241 tspsamasts ersrgghska nkpisclayl stavgclasn apsaakllvq lctqnlisaa
     3301 tgvnlttvdd siqrkflpsf lrgiaeenkl vtspnfvvtq alvalladkg aklrpnydks
     3361 evekkgliaq lyahpsydps avgplelana laacclssrl ssqhrqwaaq qlvrtlaahd
     3421 rdnqttlqtl admggdlrkc sfikleahqn rvmtcvwcnk kgllatsgnd gtirvwnvtk
     3481 kqyslqqtcv fnrlegdaee slgspsdpsf spvswsisgk ylagalekmv niwqvnggkg
     3541 lvdiqphwvs alawpeegpa tawsgespel llvgrmdgsl glievvdvst mhrrelehcy
     3601 rkdvsvtcia wfsedrpfav gyfdgklllg tkeplekggi vlidahkdtl ismkwdptgh
     3661 ilmtcakeds vklwgsisgc wcclhslchp sivngiawcr lpgkgsklql lmatgcqsgl
     3721 vcvwripqdt tqtnvtsaeg wweqesncqd gyrkssgakc vyqlrghitp vrtvafssdg
     3781 lalvsgglgg lmniwslrdg svlqtvvigs gaiqttvwip evgvaacsnr skdvlvvnct
     3841 aewaaanhvl atcrtalkqq gvlglnmapc mraflerlpm mlqeqyayek phvvcgdqlv
     3901 hspymqclas lavglhldql lcnppvpphh qnclpdpasw npnewawlec fsttikaaea
     3961 ltngaqfpes ftvpdlepvp edelvflmdn skwingmdeq imswatsrpe dwhlggkcdv
     4021 ylwgagrhgq laeagrnvmv paaapsfsqa qqvicgqnct fviqangtvl acgegsygrl
     4081 gqgnsddlhv ltvisalqgf vvtqlvtscg sdghsmalte sgevfswgdg dygklghgns
     4141 drqrrprqie alqgeevvqm scgfkhsavv tsdgklftfg ngdygrlglg ntsnkklper
     4201 vtalegyqig qvacglnhtl avsadgsmvw afgdgdygkl glgnstakss pqkidvlcgi
     4261 gikkvacgtq fsvaltkdgh vytfgqdrli glpegrarnh nrpqqipvla gviiedvavg
     4321 aehtlalasn gdvyawgsns egqlglghtn hvreptlvtg lqgknvrqis agrchsaawt
     4381 appvpprapg vsvplqlglp dtvppqygal revsihtvra rlrllyhfsd lmysswrlln
     4441 lspnnqnsts hynagtwgiv qgqlrpllap rvytlpmvrs igktmvqgkn ygpqitvkri
     4501 strgrkckpi fvqiarqvvk lnasdlrlps rawkvklvge gaddaggvfd dtitemcqel
     4561 etgivdllip spnataevgy nrdrflfnps acldehlmqf kflgilmgva irtkkpldlh
     4621 laplvwkqlc cvpltledle evdllyvqtl nsilhiedsg iteesfhemi pldsfvgqsa
     4681 dgkmvpiipg gnsipltfsn rkeyveraie yrlhemdrqv aavregmswi vpvpllsllt
     4741 akqleqmvcg mpeisvevlk kvvryrevde qhqlvqwfwh tleefsneer vlfmrfvsgr
     4801 srlpantadi sqrfqimkvd rpydslptsq tcffqlrlpp yssqlvmaer lryainncrs
     4861 idmdnymlsr nvdnaegsdt dy
//
LOCUS       XP_047289193            4882 aa            linear   PRI 05-AUG-2025
DEFINITION  putative E3 ubiquitin-protein ligase HERC1 isoform X19 [Homo
            sapiens].
ACCESSION   XP_047289193
VERSION     XP_047289193.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433237.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4882
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4882
                     /product="putative E3 ubiquitin-protein ligase HERC1
                     isoform X19"
                     /calculated_mol_wt=534335
     Region          374..703
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          683..733
                     /region_name="RCC1"
                     /note="Regulator of chromosome condensation (RCC1) repeat;
                     pfam00415"
                     /db_xref="CDD:395335"
     Region          2031..2188
                     /region_name="SPRY_HERC1"
                     /note="SPRY domain in HERC1; cd12881"
                     /db_xref="CDD:293939"
     Region          2752..2795
                     /region_name="UBA_HERC1"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC1 and similar proteins; cd14401"
                     /db_xref="CDD:270584"
     Region          <3408..3799
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          3453..3496
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3510..3545
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3550..3597
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3606..3641
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3650..3686
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3693..3724
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3771..3807
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          4020..4356
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          4494..4862
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4499,4540,4551,4618,4796,4826..4827,4830..4834,4854,
                     4861)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4646,4649..4650,4652..4653,4656,4664,4666,
                     4670..4671,4673,4682,4687,4704,4708)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4882
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /coded_by="XM_047433237.1:3472..18120"
                     /db_xref="GeneID:8925"
                     /db_xref="HGNC:HGNC:4867"
                     /db_xref="MIM:605109"
ORIGIN      
        1 matmippvkl kwlehlnssw itedsesiat regvavlysk lvsnkevvpl pqqvlclkgp
       61 qlpdferesl ssdeqdhyld allssqlala kmvcsdspfa galrkrllvl qrvfyalsnk
      121 yhdkgkvkqq qhspesssgs advhsvserp rsstdaliem gvrtglsllf allrqswmmp
      181 vsgpglslcn dvihtaievv sslpplslan eskippmgld clsqvttflk gvtipnsgad
      241 tlgrrlasel llglaaqrgs lryllewiem algasavvht mekgkllssq egmisfdcfm
      301 tilmqmrrsl gssadrsqwr eptrtsdglc slyeaalclf eevcrmasdy srtcaspdsi
      361 qtgdapivse tcevyvwgsn sshqlvegtq ekilqpklap sfsdaqtiea gqyctfvist
      421 dgsvracgkg sygrlglgds nnqstlkklt fephrsikkv ssskgsdght lafttegevf
      481 swgdgdygkl ghgnsstqky pkliqgplqg kvvvcvsagy rhsaavtedg elytwgegdf
      541 grlghgdsns rniptlvkdi snvgevscgs shtialskdg rtvwsfgggd ngklghgdtn
      601 rvykpkviea lqgmfirkvc agsqsslalt stgqvyawgc gaclgcgsse atalrpklie
      661 elaatrivdv sigdshclal shdnevyawg nnsmgqcgqg nstgpitkpk kvsgldgiai
      721 qqisagtshs lawtalprdr qvvawhrpyc vdleestfsh lrsflerycd kinseipplp
      781 fpssrehhsf lklclkllsn hlalalaggv atsilgrqag plrnllfrlm dstvpdeiqe
      841 vvietlsvga tmllpplrer mellhsllpq gpdrweslsk gqrmqldiil tslqdhthva
      901 sllgysspsd aadlssvctg ygnlsdqpyg tqschpdthl aeilmktllr nlgfytdqaf
      961 geleknsdkf llgtsssens qpahlhellc slqkqllafc hinnisenss svallhkhlq
     1021 lllphatdiy srsanllkes pwngsvgekl rdviyvsaag smlcqivnsl lllpvsvarp
     1081 llsylldllp pldclnrllp aadlledqel qwplhggpel idpaglplpq paqswvwlvd
     1141 lertiallig rclggmlqgs pvspeeqdta ywmktplfsd gvemdtpqld kcmsclleva
     1201 lsgneeqkpf dyklrpeiav yvdlalgcsk eparslwism qdyavskdwd satlsnesll
     1261 dtvsrfvlaa llkhtnllsq acgesryqpg khlsevyrcv ykvrsrllac knleliqtrs
     1321 ssrdrwisen qdsadvdpqe hsftrtidee aemeeqaerd reeghpeped eeeerehevm
     1381 tagkifqcfl sarevarsrd rdrmnsgags garaddpppq sqqerrvstd lpegqdvyta
     1441 acnsvihrca llilgvspvi delqkrreeg qlqqpstsas eggglmtrse sltaesrlvh
     1501 tspnyrliks rsesdlsqpe sdeegyalsg rrnvdldlaa shrkrgpmhs qleslsdswa
     1561 rlkhsrdwlc nssysfesdf dltkslgvht lienvvsfvs gdvgnapgfk epeesmstsp
     1621 qasiiameqq qlraelrlea lhqilvllsg meekgsisla gsrlssgfqs stlltsvrlq
     1681 flagcfglgt vghtggkges grlhhyqdgi raakrniqie iqvavhkiyq qlsatleral
     1741 qankhhieaq qrlllvtvfa lsvhyqpvdv slaistglln vlsqlcgtdt mlgqplqllp
     1801 ktgvsqlsta lkvastrllq ilaittgtya dklspkvvqs lldllcsqlk nllsqtgvlh
     1861 masfgegeqe dgeeeekkvd ssgetekkdf raalrkqhaa elhlgdflvf lrrvvsskai
     1921 qskmaspkwt evllniasqk cssgiplvgn lrtrllalhv leavlpaces gveddqmaqi
     1981 verlfsllsd cmwetpiaqa khaiqikeke qeiklqqgel eeedenlpiq evsfdpekaq
     2041 cclvengqil thgsggkgyg lastgvtsgc yqwkfyivke nrgnegtcvg vsrwpvhdfn
     2101 hrttsdmwly raysgnlyhn geqtltlssf tqgdfitcvl dmeartisfg kngeepklaf
     2161 edvdaaelyp cvmfyssnpg ekvkicdmqm rgtprdllpg dpicspvaav laeatiqlir
     2221 ilhrtdrwty cinkkmmerl hkikicikes gqklkksrsv qsreenemre ekeskeeekg
     2281 khtrhgladl selqlrtlci evwpvlavig gvdaglrvgg rcvhkqtgrh atllgvvkeg
     2341 stsakvqwde aeitisfptf wspsdtplyn lepceplpfd varfrgltas vlldltyltg
     2401 vhedmgkqst krhekkhrhe seekgdveqk pesesaldmr tgltsddvks qsttssksen
     2461 eiasfsldpt lpsvesqhqi tegkrknheh msknhdvaqs eiravqlsyl ylgamkslsa
     2521 llgcskyael llipkvlaen ghnsdcassp vvhedvemra alqflmrhmv kravmrspik
     2581 ralgladler aqamiyklvv hglledqfgg kikqeidqqa eesdpaqqaq tpvttspsas
     2641 sttsfmsssl edtttattpv tdtetvpase spgvmplsll rqmfssyptt tvlptrraqt
     2701 ppisslptsp sdevgrrqsl tspdsqsarp anrtalsdps srlstspppp aiavpllemg
     2761 fslrqiakam eatgargead aqnitvlamw miehpghede eepqsgstad srpgaavlgs
     2821 ggksndpcyl qspgdipsad aaemeegfse spdnldhten aasgsgpsar grsavtrrhk
     2881 fdlaartlla raaglyrsvq ahrnqsrreg islqqdpgal ydfnldeele idlddeamea
     2941 mfgqdltsdn dilgmwipev ldwptwhvce sedreevvvc elcecsvvsf nqhmkrnhpg
     3001 cgrsanrqgy rsngsyvdgw fggecgsgnp yyllcgtcre kylamktksk stsserykgq
     3061 apdligkqds vyeedwdmld vdedekltge eefellagpl glndrrivpe pvqfpdsdpl
     3121 gasvamvtat nsmeetlmqi elcfsgchgs veksssgrit lgeqaaalan phdrvvalrr
     3181 vtaaaqvlla rtmvmralsl lsvsgsscsl aagleslglt dirtlvrlmc laaagragls
     3241 tspsamasts ersrgghska nkpisclayl stavgclasn apsaakllvq lctqnlisaa
     3301 tgvnlttvdd siqrkflpsf lrgiaeenkl vtspnfvvtq alvalladkg aklrpnydks
     3361 evekkgliaq lyahpsydps avgplelana laacclssrl ssqhrqwaaq qlvrtlaahd
     3421 rdnqttlqtl admggdlrkc sfikleahqn rvmtcvwcnk kgllatsgnd gtirvwnvtk
     3481 kqyslqqtcv fnrlegdaee slgspsdpsf spvswsisgk ylagalekmv niwqvnggkg
     3541 lvdiqphwvs alawpeegpa tawsgespel llvgrmdgsl glievvdvst mhrrelehcy
     3601 rkdvsvtcia wfsedrpfav gyfdgklllg tkeplekggi vlidahkdtl ismkwdptgh
     3661 ilmtcakeds vklwgsisgc wcclhslchp sivngiawcr lpgkgsklql lmatgcqsgl
     3721 vcvwripqdt tqtnvtsaeg wweqesncqd gyrkssgakc vyqlrghitp vrtvafssdg
     3781 lalvsgglgg lmniwslrdg svlqtvvigs gaiqttvwip evgvaacsnr skdvlvvnct
     3841 aewaaanhvl atcrtalkqq gvlglnmapc mraflerlpm mlqeqyayek phvvcgdqlv
     3901 hspymqclas lavglhldql lcnppvpphh qnclpdpasw npnewawlec fsttikaaea
     3961 ltngaqfpes ftvpdlepvp edelvflmdn skwingmdeq imswatsrpe dwhlggkcdv
     4021 ylwgagrhgq laeagrnvmv paaapsfsqa qqvicgqnct fviqangtvl acgegsygrl
     4081 gqgnsddlhv ltvisalqgf vvtqlvtscg sdghsmalte sgevfswgdg dygklghgns
     4141 drqrrprqie alqgeevvqm scgfkhsavv tsdgklftfg ngdygrlglg ntsnkklper
     4201 vtalegyqig qvacglnhtl avsadgsmvw afgdgdygkl glgnstakss pqkidvlcgi
     4261 gikkvacgtq fsvaltkdgh vytfgqdrli glpegrarnh nrpqqipvla gviiedvavg
     4321 aehtlalasn gdvyawgsns egqlglghtn hvreptlvtg lqgknvrqis agrchsaawt
     4381 appvpprapg vsvplqlglp dtvppqygal revsihtvra rlrllyhfsd lmysswrlln
     4441 lspnnqnsts hynagtwgiv qgqlrpllap rvytlpmvrs igktmvqgkn ygpqitvkri
     4501 strgrkckpi fvqiarqvvk lnasdlrlps rawkvklvge gaddaggvfd dtitemcqel
     4561 etgivdllip spnataevgy nrdrflfnps acldehlmqf kflgilmgva irtkkpldlh
     4621 laplvwkqlc cvpltledle evdllyvqtl nsilhiedsg iteesfhemi pldsfvgqsa
     4681 dgkmvpiipg gnsipltfsn rkeyveraie yrlhemdrqv aavregmswi vpvpllsllt
     4741 akqleqmvcg mpeisvevlk kvvryrevde qhqlvqwfwh tleefsneer vlfmrfvsgr
     4801 srlpantadi sqrfqimkvd rpydslptsq tcffqlrlpp yssqlvmaer lryainncrs
     4861 idmdnymlsr nvdnaegsdt dy
//
LOCUS       XP_047289194            4878 aa            linear   PRI 05-AUG-2025
DEFINITION  putative E3 ubiquitin-protein ligase HERC1 isoform X20 [Homo
            sapiens].
ACCESSION   XP_047289194
VERSION     XP_047289194.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433238.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4878
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4878
                     /product="putative E3 ubiquitin-protein ligase HERC1
                     isoform X20"
                     /calculated_mol_wt=533884
     Region          374..703
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          683..733
                     /region_name="RCC1"
                     /note="Regulator of chromosome condensation (RCC1) repeat;
                     pfam00415"
                     /db_xref="CDD:395335"
     Region          2032..2189
                     /region_name="SPRY_HERC1"
                     /note="SPRY domain in HERC1; cd12881"
                     /db_xref="CDD:293939"
     Region          2753..2796
                     /region_name="UBA_HERC1"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC1 and similar proteins; cd14401"
                     /db_xref="CDD:270584"
     Region          <3404..3795
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          3449..3492
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3506..3541
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3546..3593
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3602..3637
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3646..3682
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3689..3720
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3767..3803
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          4016..4352
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          4490..4858
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4495,4536,4547,4614,4792,4822..4823,4826..4830,4850,
                     4857)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4642,4645..4646,4648..4649,4652,4660,4662,
                     4666..4667,4669,4678,4683,4700,4704)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4878
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /coded_by="XM_047433238.1:149..14785"
                     /db_xref="GeneID:8925"
                     /db_xref="HGNC:HGNC:4867"
                     /db_xref="MIM:605109"
ORIGIN      
        1 matmippvkl kwlehlnssw itedsesiat regvavlysk lvsnkevvpl pqqvlclkgp
       61 qlpdferesl ssdeqdhyld allssqlala kmvcsdspfa galrkrllvl qrvfyalsnk
      121 yhdkgkvkqq qhspesssgs advhsvserp rsstdaliem gvrtglsllf allrqswmmp
      181 vsgpglslcn dvihtaievv sslpplslan eskippmgld clsqvttflk gvtipnsgad
      241 tlgrrlasel llglaaqrgs lryllewiem algasavvht mekgkllssq egmisfdcfm
      301 tilmqmrrsl gssadrsqwr eptrtsdglc slyeaalclf eevcrmasdy srtcaspdsi
      361 qtgdapivse tcevyvwgsn sshqlvegtq ekilqpklap sfsdaqtiea gqyctfvist
      421 dgsvracgkg sygrlglgds nnqstlkklt fephrsikkv ssskgsdght lafttegevf
      481 swgdgdygkl ghgnsstqky pkliqgplqg kvvvcvsagy rhsaavtedg elytwgegdf
      541 grlghgdsns rniptlvkdi snvgevscgs shtialskdg rtvwsfgggd ngklghgdtn
      601 rvykpkviea lqgmfirkvc agsqsslalt stgqvyawgc gaclgcgsse atalrpklie
      661 elaatrivdv sigdshclal shdnevyawg nnsmgqcgqg nstgpitkpk kvsgldgiai
      721 qqisagtshs lawtalprdr qvvawhrpyc vdleestfsh lrsflerycd kinseipplp
      781 fpssrehhsf lklclkllsn hlalalaggv atsilgrqag plrnllfrlm dstvpdeiqe
      841 vvietlsvga tmllpplrer mellhsllpq gpdrweslsk gqrmqldiil tslqdhthva
      901 sllgysspsd aadlssvctg ygnlsdqpyg tqschpdthl aeilmktllr nlgfytdqaf
      961 geleknsdkf llgtsssens qpahlhellc slqkqllafc hinnisenss svallhkhlq
     1021 lllphatdiy srsanllkes pwngsvgekl rdviyvsaag smlcqivnsl lllpvsvarp
     1081 llsylldllp pldclnrllp aadlledqel qwplhggpel idpaglplpq paqswvwlvd
     1141 lertiallig rclggmlqgs pvspeeqdta ywmktplfsd gvemdtpqld kcmsclleva
     1201 lsgneeqkpf dyklrpeiav yvdlalgcsk eparslwism qdyavskdwd satlsnesll
     1261 dtvsrfvlaa llkhtnllsq acgesryqpg khlsevyrcv ykvrsrllac knleliqtrs
     1321 ssrdrwisen qdsadvdpqe hsftrtidee aemeeqaerd reeghpeped eeeerehevm
     1381 tagkifqcfl sarevarsrd rdrmnsgags garaddpppq sqqerrvstd lpegqdvyta
     1441 acnsvihrca llilgvspvi delqkrreeg qlqqpstsas eggglmtrse sltaesrlvh
     1501 tspnyrliks rsesdlsqpe sdeegyalsg rrnvdldlaa shrkrgpmhs qleslsdswa
     1561 rlkhsrdwlc nssysfesdf dltkslgvht lienvvsfvs gdvgnapgfk epeesmstsp
     1621 qasiiameqq qlraelrlea lhqilvllsg meekgsisla gsrlssgfqs stlltsvrlq
     1681 flagcfglgt vghtggkges grlhhyqdgi raakrniqie iqvavhkiyq qlsatleral
     1741 qankhhieaq qrlllvtvfa lsvhyqpvdv slaistglln vlsqlcgtdt mlgqplqllp
     1801 ktgvsqlsta lkvastrllq ilaittgtya dklspkvvqs lldllcsqlk nllsqtgvlh
     1861 masfgegeqe dgeeeekkvd ssgetekkdf raalrkqhaa elhlgdflvf lrrvvsskai
     1921 qskmaspkwt evllniasqk cssgiplvgn lrtrllalhv leavlpaces gveddqmaqi
     1981 verlfsllsd cmwetpiaqa khaiqikeke qeiklqkqge leeedenlpi qevsfdpeka
     2041 qcclvengqi lthgsggkgy glastgvtsg cyqwkfyivk enrgnegtcv gvsrwpvhdf
     2101 nhrttsdmwl yraysgnlyh ngeqtltlss ftqgdfitcv ldmeartisf gkngeepkla
     2161 fedvdaaely pcvmfyssnp gekvkicdmq mrgtprdllp gdpicspvaa vlaeatiqli
     2221 rilhrtdrwt ycinkkmmer lhkikicike sgqklkksrs vqsreenemr eekeskeeek
     2281 gkhtrhglad lselqlrtlc ievwpvlavi ggvdaglrvg grcvhkqtgr hatllgvvke
     2341 gstsakvqwd eaeitisfpt fwspsdtply nlepceplpf dvarfrglta svlldltylt
     2401 gvhedmgkqs tkrhekkhrh eseekgdveq kpesesaldm rtgltsddvk sqsttsskse
     2461 neiasfsldp tlpsvesqhq itegkrknhe hmsknhdvaq seiravqlsy lylgamksls
     2521 allgcskyae lllipkvlae nghnsdcass pvvhedvemr aalqflmrhm vkravmrspi
     2581 kralgladle raqamiyklv vhglledqfg gkikqeidqq aeesdpaqqa qtpvttspsa
     2641 ssttsfmsss ledtttattp vtdtetvpas espgvmplsl lrqmfssypt ttvlptrraq
     2701 tppisslpts psdevgrrqs ltspdsqsar panrtalsdp ssrlstsppp paiavpllem
     2761 gfslrqiaka meatgargea daqnitvlam wmiehpghed eeepqsgsta dsrpgaavlg
     2821 sggksndpcy lqspgdipsa daaemeegfs espdnldhte naasgsgpsa rgrsavtrrh
     2881 kfdlaartll araaglyrsv qahrnqsrre gislqqdpga lydfnldeel eidlddeame
     2941 amfgqdltsd ndilgmwipe vldwptwhvc esedreevvv celcecsvvs fnqhmkrnhp
     3001 gcgrsanrqg yrsngsyvdg wfggecgsgn pyyllcgtcr ekylamktks kstsserykg
     3061 qapdligkqd svyeedwdml dvdedekltg eeefellagp lglndrrivp epvqfpdsdp
     3121 lgasvamvta tnsmeetlmq igchgsveks ssgritlgeq aaalanphdr vvalrrvtaa
     3181 aqvllartmv mralsllsvs gsscslaagl eslgltdirt lvrlmclaaa graglstsps
     3241 amastsersr gghskankpi sclaylstav gclasnapsa akllvqlctq nlisaatgvn
     3301 lttvddsiqr kflpsflrgi aeenklvtsp nfvvtqalva lladkgaklr pnydksevek
     3361 kgliaqlyah psydpsavgp lelanalaac clssrlssqh rqwaaqqlvr tlaahdrdnq
     3421 ttlqtladmg gdlrkcsfik leahqnrvmt cvwcnkkgll atsgndgtir vwnvtkkqys
     3481 lqqtcvfnrl egdaeeslgs psdpsfspvs wsisgkylag alekmvniwq vnggkglvdi
     3541 qphwvsalaw peegpataws gespelllvg rmdgslglie vvdvstmhrr elehcyrkdv
     3601 svtciawfse drpfavgyfd gklllgtkep lekggivlid ahkdtlismk wdptghilmt
     3661 cakedsvklw gsisgcwccl hslchpsivn giawcrlpgk gsklqllmat gcqsglvcvw
     3721 ripqdttqtn vtsaegwweq esncqdgyrk ssgakcvyql rghitpvrtv afssdglalv
     3781 sgglgglmni wslrdgsvlq tvvigsgaiq ttvwipevgv aacsnrskdv lvvnctaewa
     3841 aanhvlatcr talkqqgvlg lnmapcmraf lerlpmmlqe qyayekphvv cgdqlvhspy
     3901 mqclaslavg lhldqllcnp pvpphhqncl pdpaswnpne wawlecfstt ikaaealtng
     3961 aqfpesftvp dlepvpedel vflmdnskwi ngmdeqimsw atsrpedwhl ggkcdvylwg
     4021 agrhgqlaea grnvmvpaaa psfsqaqqvi cgqnctfviq angtvlacge gsygrlgqgn
     4081 sddlhvltvi salqgfvvtq lvtscgsdgh smaltesgev fswgdgdygk lghgnsdrqr
     4141 rprqiealqg eevvqmscgf khsavvtsdg klftfgngdy grlglgntsn kklpervtal
     4201 egyqigqvac glnhtlavsa dgsmvwafgd gdygklglgn staksspqki dvlcgigikk
     4261 vacgtqfsva ltkdghvytf gqdrliglpe grarnhnrpq qipvlagvii edvavgaeht
     4321 lalasngdvy awgsnsegql glghtnhvre ptlvtglqgk nvrqisagrc hsaawtappv
     4381 pprapgvsvp lqlglpdtvp pqygalrevs ihtvrarlrl lyhfsdlmys swrllnlspn
     4441 nqnstshyna gtwgivqgql rpllaprvyt lpmvrsigkt mvqgknygpq itvkristrg
     4501 rkckpifvqi arqvvklnas dlrlpsrawk vklvgegadd aggvfddtit emcqeletgi
     4561 vdllipspna taevgynrdr flfnpsacld ehlmqfkflg ilmgvairtk kpldlhlapl
     4621 vwkqlccvpl tledleevdl lyvqtlnsil hiedsgitee sfhemiplds fvgqsadgkm
     4681 vpiipggnsi pltfsnrkey veraieyrlh emdrqvaavr egmswivpvp llslltakql
     4741 eqmvcgmpei svevlkkvvr yrevdeqhql vqwfwhtlee fsneervlfm rfvsgrsrlp
     4801 antadisqrf qimkvdrpyd slptsqtcff qlrlppyssq lvmaerlrya inncrsidmd
     4861 nymlsrnvdn aegsdtdy
//
LOCUS       XP_047289195            4877 aa            linear   PRI 05-AUG-2025
DEFINITION  putative E3 ubiquitin-protein ligase HERC1 isoform X21 [Homo
            sapiens].
ACCESSION   XP_047289195
VERSION     XP_047289195.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433239.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4877
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4877
                     /product="putative E3 ubiquitin-protein ligase HERC1
                     isoform X21"
                     /calculated_mol_wt=533890
     Region          374..703
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          683..733
                     /region_name="RCC1"
                     /note="Regulator of chromosome condensation (RCC1) repeat;
                     pfam00415"
                     /db_xref="CDD:395335"
     Region          2063..2220
                     /region_name="SPRY_HERC1"
                     /note="SPRY domain in HERC1; cd12881"
                     /db_xref="CDD:293939"
     Region          2776..2819
                     /region_name="UBA_HERC1"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC1 and similar proteins; cd14401"
                     /db_xref="CDD:270584"
     Region          <3403..3794
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          3448..3491
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3505..3540
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3545..3592
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3601..3636
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3645..3681
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3688..3719
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3766..3802
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          4015..4351
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          4489..4857
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4494,4535,4546,4613,4791,4821..4822,4825..4829,4849,
                     4856)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4641,4644..4645,4647..4648,4651,4659,4661,
                     4665..4666,4668,4677,4682,4699,4703)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4877
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /coded_by="XM_047433239.1:154..14787"
                     /db_xref="GeneID:8925"
                     /db_xref="HGNC:HGNC:4867"
                     /db_xref="MIM:605109"
ORIGIN      
        1 matmippvkl kwlehlnssw itedsesiat regvavlysk lvsnkevvpl pqqvlclkgp
       61 qlpdferesl ssdeqdhyld allssqlala kmvcsdspfa galrkrllvl qrvfyalsnk
      121 yhdkgkvkqq qhspesssgs advhsvserp rsstdaliem gvrtglsllf allrqswmmp
      181 vsgpglslcn dvihtaievv sslpplslan eskippmgld clsqvttflk gvtipnsgad
      241 tlgrrlasel llglaaqrgs lryllewiem algasavvht mekgkllssq egmisfdcfm
      301 tilmqmrrsl gssadrsqwr eptrtsdglc slyeaalclf eevcrmasdy srtcaspdsi
      361 qtgdapivse tcevyvwgsn sshqlvegtq ekilqpklap sfsdaqtiea gqyctfvist
      421 dgsvracgkg sygrlglgds nnqstlkklt fephrsikkv ssskgsdght lafttegevf
      481 swgdgdygkl ghgnsstqky pkliqgplqg kvvvcvsagy rhsaavtedg elytwgegdf
      541 grlghgdsns rniptlvkdi snvgevscgs shtialskdg rtvwsfgggd ngklghgdtn
      601 rvykpkviea lqgmfirkvc agsqsslalt stgqvyawgc gaclgcgsse atalrpklie
      661 elaatrivdv sigdshclal shdnevyawg nnsmgqcgqg nstgpitkpk kvsgldgiai
      721 qqisagtshs lawtalprdr qvvawhrpyc vdleestfsh lrsflerycd kinseipplp
      781 fpssrehhsf lklclkllsn hlalalaggv atsilgrqag plrnllfrlm dstvpdeiqe
      841 vvietlsvga tmllpplrer mellhsllpq gpdrweslsk gqrmqldiil tslqdhthva
      901 sllgysspsd aadlssvctg ygnlsdqpyg tqschpdthl aeilmktllr nlgfytdqaf
      961 geleknsdkf llgtsssens qpahlhellc slqkqllafc hinnisenss svallhkhlq
     1021 lllphatdiy srsanllkes pwngsvgekl rdviyvsaag smlcqivnsl lllpvsvarp
     1081 llsylldllp pldclnrllp aadlledqel qwplhggpel idpaglplpq paqswvwlvd
     1141 lertiallig rclggmlqgs pvspeeqdta ywmktplfsd gvemdtpqld kcmsclleva
     1201 lsgneeqkpf dyklrpeiav yvdlalgcsk eparslwism qdyavskdwd satlsnesll
     1261 dtvsrfvlaa llkhtnllsq acgesryqpg khlsevyrcv ykvrsrllac knleliqtrs
     1321 ssrdrwisen qdsadvdpqe hsftrtidee aemeeqaerd reeghpeped eeeerehevm
     1381 tagnlvfvlh vteifqcfls arevarsrdr drmnsgagsg araddpppqs qqerrvstdl
     1441 pegqdvytaa cnsvihrcal lilgvspvid elqkrreegq lqqpstsase ggglmtrses
     1501 ltaesrlvht spnyrliksr sesdlsqpes deegyalsgr rnvdldlaas hrkrvylllf
     1561 gqlsprkkks fkqvhdgpmh sqleslsdsw arlkhsrdwl cnssysfesd fdltkslgvh
     1621 tlienvvsfv sgdvgnapgf kepeesmsts pqasiiameq qqlraelrle alhqilvlls
     1681 gmeekgsisl agsrlssgfq sstlltsvrl qflagcfglg tvghtggkge sgrlhhyqdg
     1741 iraakrniqi eiqvavhkiy qqlsatlera lqankhhiea qqrlllvtvf alsvhyqpvd
     1801 vslaistgll nvlsqlcgtd tmlgqplqll pktgvsqlst alkvastrll qilaittgty
     1861 adklspkvvq slldllcsql knllsqtgvl hmasfgegeq edgeeeekkv dssgetekkd
     1921 fraalrkqha aelhlgdflv flrrvvsska iqskmaspkw tevllniasq kcssgiplvg
     1981 nlrtrllalh vleavlpace sgveddqmaq iverlfslls dcmwetpiaq akhaiqikek
     2041 eqeiklqkqg eleeedenlp iqevsfdpek aqcclvengq ilthgsggkg yglastgvts
     2101 gcyqwkfyiv kenrgnegtc vgvsrwpvhd fnhrttsdmw lyraysgnly hngeqtltls
     2161 sftqgdfitc vldmeartis fgkngeepkl afedvdaael ypcvmfyssn pgekvkicdm
     2221 qmrgtprdll pgdpicspva avlaeatiql irilhrtdrw tycinkkmme rlhkikicik
     2281 esgqklkksr svqsreenem reekeskeee kgkhtrhgla dlselqlrtl cievwpvlav
     2341 iggvdaglrv ggrcvhkqtg rhatllgvvk egstsakvqw deaeitisdt plynlepcep
     2401 lpfdvarfrg ltasvlldlt yltgvhedmg kqstkrhekk hrheseekgd veqkpesesa
     2461 ldmrtgltsd dvksqsttss kseneiasfs ldptlpsves qhqitegkrk nhehmsknhd
     2521 vaqseiravq lsylylgamk slsallgcsk yaelllipkv laenghnsdc asspvvhedv
     2581 emraalqflm rhmvkravmr spikralgla dleraqamiy klvvhglled qfggkikqei
     2641 dqqaeesdpa qqaqtpvtts psassttsfm sssledttta ttpvtdtetv pasespgvmp
     2701 lsllrqmfss yptttvlptr raqtppissl ptspsdevgr rqsltspdsq sarpanrtal
     2761 sdpssrlsts ppppaiavpl lemgfslrqi akameatgar geadaqnitv lamwmiehpg
     2821 hedeeepqsg stadsrpgaa vlgsggksnd pcylqspgdi psadaaemee gfsespdnld
     2881 htenaasgsg psargrsavt rrhkfdlaar tllaraagly rsvqahrnqs rregislqqd
     2941 pgalydfnld eeleidldde ameamfgqdl tsdndilgmw ipehvcesed reevvvcelc
     3001 ecsvvsfnqh mkrnhpgcgr sanrqgyrsn gsyvdgwfgg ecgsgnpyyl lcgtcrekyl
     3061 amktksksts serykgqapd ligkqdsvye edwdmldvde dekltgeeef ellagplgln
     3121 drrivpepvq fpdsdplgas vamvtatnsm eetlmqigch gsveksssgr itlgeqaaal
     3181 anphdrvval rrvtaaaqvl lartmvmral sllsvsgssc slaagleslg ltdirtlvrl
     3241 mclaaagrag lstspsamas tsersrgghs kankpiscla ylstavgcla snapsaakll
     3301 vqlctqnlis aatgvnlttv ddsiqrkflp sflrgiaeen klvtspnfvv tqalvallad
     3361 kgaklrpnyd ksevekkgpl elanalaacc lssrlssqhr qwaaqqlvrt laahdrdnqt
     3421 tlqtladmgg dlrkcsfikl eahqnrvmtc vwcnkkglla tsgndgtirv wnvtkkqysl
     3481 qqtcvfnrle gdaeeslgsp sdpsfspvsw sisgkylaga lekmvniwqv nggkglvdiq
     3541 phwvsalawp eegpatawsg espelllvgr mdgslgliev vdvstmhrre lehcyrkdvs
     3601 vtciawfsed rpfavgyfdg klllgtkepl ekggivlida hkdtlismkw dptghilmtc
     3661 akedsvklwg sisgcwcclh slchpsivng iawcrlpgkg sklqllmatg cqsglvcvwr
     3721 ipqdttqtnv tsaegwweqe sncqdgyrks sgakcvyqlr ghitpvrtva fssdglalvs
     3781 gglgglmniw slrdgsvlqt vvigsgaiqt tvwipevgva acsnrskdvl vvnctaewaa
     3841 anhvlatcrt alkqqgvlgl nmapcmrafl erlpmmlqeq yayekphvvc gdqlvhspym
     3901 qclaslavgl hldqllcnpp vpphhqnclp dpaswnpnew awlecfstti kaaealtnga
     3961 qfpesftvpd lepvpedelv flmdnskwin gmdeqimswa tsrpedwhlg gkcdvylwga
     4021 grhgqlaeag rnvmvpaaap sfsqaqqvic gqnctfviqa ngtvlacgeg sygrlgqgns
     4081 ddlhvltvis alqgfvvtql vtscgsdghs maltesgevf swgdgdygkl ghgnsdrqrr
     4141 prqiealqge evvqmscgfk hsavvtsdgk lftfgngdyg rlglgntsnk klpervtale
     4201 gyqigqvacg lnhtlavsad gsmvwafgdg dygklglgns taksspqkid vlcgigikkv
     4261 acgtqfsval tkdghvytfg qdrliglpeg rarnhnrpqq ipvlagviie dvavgaehtl
     4321 alasngdvya wgsnsegqlg lghtnhvrep tlvtglqgkn vrqisagrch saawtappvp
     4381 prapgvsvpl qlglpdtvpp qygalrevsi htvrarlrll yhfsdlmyss wrllnlspnn
     4441 qnstshynag twgivqgqlr pllaprvytl pmvrsigktm vqgknygpqi tvkristrgr
     4501 kckpifvqia rqvvklnasd lrlpsrawkv klvgegadda ggvfddtite mcqeletgiv
     4561 dllipspnat aevgynrdrf lfnpsaclde hlmqfkflgi lmgvairtkk pldlhlaplv
     4621 wkqlccvplt ledleevdll yvqtlnsilh iedsgitees fhemipldsf vgqsadgkmv
     4681 piipggnsip ltfsnrkeyv eraieyrlhe mdrqvaavre gmswivpvpl lslltakqle
     4741 qmvcgmpeis vevlkkvvry revdeqhqlv qwfwhtleef sneervlfmr fvsgrsrlpa
     4801 ntadisqrfq imkvdrpyds lptsqtcffq lrlppyssql vmaerlryai nncrsidmdn
     4861 ymlsrnvdna egsdtdy
//
LOCUS       XP_047289196            4876 aa            linear   PRI 05-AUG-2025
DEFINITION  putative E3 ubiquitin-protein ligase HERC1 isoform X22 [Homo
            sapiens].
ACCESSION   XP_047289196
VERSION     XP_047289196.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433240.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4876
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4876
                     /product="putative E3 ubiquitin-protein ligase HERC1
                     isoform X22"
                     /calculated_mol_wt=533762
     Region          374..703
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          683..733
                     /region_name="RCC1"
                     /note="Regulator of chromosome condensation (RCC1) repeat;
                     pfam00415"
                     /db_xref="CDD:395335"
     Region          2062..2219
                     /region_name="SPRY_HERC1"
                     /note="SPRY domain in HERC1; cd12881"
                     /db_xref="CDD:293939"
     Region          2775..2818
                     /region_name="UBA_HERC1"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC1 and similar proteins; cd14401"
                     /db_xref="CDD:270584"
     Region          <3402..3793
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          3447..3490
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3504..3539
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3544..3591
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3600..3635
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3644..3680
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3687..3718
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3765..3801
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          4014..4350
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          4488..4856
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4493,4534,4545,4612,4790,4820..4821,4824..4828,4848,
                     4855)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4640,4643..4644,4646..4647,4650,4658,4660,
                     4664..4665,4667,4676,4681,4698,4702)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4876
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /coded_by="XM_047433240.1:154..14784"
                     /db_xref="GeneID:8925"
                     /db_xref="HGNC:HGNC:4867"
                     /db_xref="MIM:605109"
ORIGIN      
        1 matmippvkl kwlehlnssw itedsesiat regvavlysk lvsnkevvpl pqqvlclkgp
       61 qlpdferesl ssdeqdhyld allssqlala kmvcsdspfa galrkrllvl qrvfyalsnk
      121 yhdkgkvkqq qhspesssgs advhsvserp rsstdaliem gvrtglsllf allrqswmmp
      181 vsgpglslcn dvihtaievv sslpplslan eskippmgld clsqvttflk gvtipnsgad
      241 tlgrrlasel llglaaqrgs lryllewiem algasavvht mekgkllssq egmisfdcfm
      301 tilmqmrrsl gssadrsqwr eptrtsdglc slyeaalclf eevcrmasdy srtcaspdsi
      361 qtgdapivse tcevyvwgsn sshqlvegtq ekilqpklap sfsdaqtiea gqyctfvist
      421 dgsvracgkg sygrlglgds nnqstlkklt fephrsikkv ssskgsdght lafttegevf
      481 swgdgdygkl ghgnsstqky pkliqgplqg kvvvcvsagy rhsaavtedg elytwgegdf
      541 grlghgdsns rniptlvkdi snvgevscgs shtialskdg rtvwsfgggd ngklghgdtn
      601 rvykpkviea lqgmfirkvc agsqsslalt stgqvyawgc gaclgcgsse atalrpklie
      661 elaatrivdv sigdshclal shdnevyawg nnsmgqcgqg nstgpitkpk kvsgldgiai
      721 qqisagtshs lawtalprdr qvvawhrpyc vdleestfsh lrsflerycd kinseipplp
      781 fpssrehhsf lklclkllsn hlalalaggv atsilgrqag plrnllfrlm dstvpdeiqe
      841 vvietlsvga tmllpplrer mellhsllpq gpdrweslsk gqrmqldiil tslqdhthva
      901 sllgysspsd aadlssvctg ygnlsdqpyg tqschpdthl aeilmktllr nlgfytdqaf
      961 geleknsdkf llgtsssens qpahlhellc slqkqllafc hinnisenss svallhkhlq
     1021 lllphatdiy srsanllkes pwngsvgekl rdviyvsaag smlcqivnsl lllpvsvarp
     1081 llsylldllp pldclnrllp aadlledqel qwplhggpel idpaglplpq paqswvwlvd
     1141 lertiallig rclggmlqgs pvspeeqdta ywmktplfsd gvemdtpqld kcmsclleva
     1201 lsgneeqkpf dyklrpeiav yvdlalgcsk eparslwism qdyavskdwd satlsnesll
     1261 dtvsrfvlaa llkhtnllsq acgesryqpg khlsevyrcv ykvrsrllac knleliqtrs
     1321 ssrdrwisen qdsadvdpqe hsftrtidee aemeeqaerd reeghpeped eeeerehevm
     1381 tagnlvfvlh vteifqcfls arevarsrdr drmnsgagsg araddpppqs qqerrvstdl
     1441 pegqdvytaa cnsvihrcal lilgvspvid elqkrreegq lqqpstsase ggglmtrses
     1501 ltaesrlvht spnyrliksr sesdlsqpes deegyalsgr rnvdldlaas hrkrvylllf
     1561 gqlsprkkks fkqvhdgpmh sqleslsdsw arlkhsrdwl cnssysfesd fdltkslgvh
     1621 tlienvvsfv sgdvgnapgf kepeesmsts pqasiiameq qqlraelrle alhqilvlls
     1681 gmeekgsisl agsrlssgfq sstlltsvrl qflagcfglg tvghtggkge sgrlhhyqdg
     1741 iraakrniqi eiqvavhkiy qqlsatlera lqankhhiea qqrlllvtvf alsvhyqpvd
     1801 vslaistgll nvlsqlcgtd tmlgqplqll pktgvsqlst alkvastrll qilaittgty
     1861 adklspkvvq slldllcsql knllsqtgvl hmasfgegeq edgeeeekkv dssgetekkd
     1921 fraalrkqha aelhlgdflv flrrvvsska iqskmaspkw tevllniasq kcssgiplvg
     1981 nlrtrllalh vleavlpace sgveddqmaq iverlfslls dcmwetpiaq akhaiqikek
     2041 eqeiklqqge leeedenlpi qevsfdpeka qcclvengqi lthgsggkgy glastgvtsg
     2101 cyqwkfyivk enrgnegtcv gvsrwpvhdf nhrttsdmwl yraysgnlyh ngeqtltlss
     2161 ftqgdfitcv ldmeartisf gkngeepkla fedvdaaely pcvmfyssnp gekvkicdmq
     2221 mrgtprdllp gdpicspvaa vlaeatiqli rilhrtdrwt ycinkkmmer lhkikicike
     2281 sgqklkksrs vqsreenemr eekeskeeek gkhtrhglad lselqlrtlc ievwpvlavi
     2341 ggvdaglrvg grcvhkqtgr hatllgvvke gstsakvqwd eaeitisdtp lynlepcepl
     2401 pfdvarfrgl tasvlldlty ltgvhedmgk qstkrhekkh rheseekgdv eqkpesesal
     2461 dmrtgltsdd vksqsttssk seneiasfsl dptlpsvesq hqitegkrkn hehmsknhdv
     2521 aqseiravql sylylgamks lsallgcsky aelllipkvl aenghnsdca sspvvhedve
     2581 mraalqflmr hmvkravmrs pikralglad leraqamiyk lvvhglledq fggkikqeid
     2641 qqaeesdpaq qaqtpvttsp sassttsfms ssledtttat tpvtdtetvp asespgvmpl
     2701 sllrqmfssy ptttvlptrr aqtppisslp tspsdevgrr qsltspdsqs arpanrtals
     2761 dpssrlstsp pppaiavpll emgfslrqia kameatgarg eadaqnitvl amwmiehpgh
     2821 edeeepqsgs tadsrpgaav lgsggksndp cylqspgdip sadaaemeeg fsespdnldh
     2881 tenaasgsgp sargrsavtr rhkfdlaart llaraaglyr svqahrnqsr regislqqdp
     2941 galydfnlde eleidlddea meamfgqdlt sdndilgmwi pehvcesedr eevvvcelce
     3001 csvvsfnqhm krnhpgcgrs anrqgyrsng syvdgwfgge cgsgnpyyll cgtcrekyla
     3061 mktkskstss erykgqapdl igkqdsvyee dwdmldvded ekltgeeefe llagplglnd
     3121 rrivpepvqf pdsdplgasv amvtatnsme etlmqigchg sveksssgri tlgeqaaala
     3181 nphdrvvalr rvtaaaqvll artmvmrals llsvsgsscs laagleslgl tdirtlvrlm
     3241 claaagragl stspsamast sersrgghsk ankpisclay lstavgclas napsaakllv
     3301 qlctqnlisa atgvnlttvd dsiqrkflps flrgiaeenk lvtspnfvvt qalvalladk
     3361 gaklrpnydk sevekkgple lanalaaccl ssrlssqhrq waaqqlvrtl aahdrdnqtt
     3421 lqtladmggd lrkcsfikle ahqnrvmtcv wcnkkgllat sgndgtirvw nvtkkqyslq
     3481 qtcvfnrleg daeeslgsps dpsfspvsws isgkylagal ekmvniwqvn ggkglvdiqp
     3541 hwvsalawpe egpatawsge spelllvgrm dgslglievv dvstmhrrel ehcyrkdvsv
     3601 tciawfsedr pfavgyfdgk lllgtkeple kggivlidah kdtlismkwd ptghilmtca
     3661 kedsvklwgs isgcwcclhs lchpsivngi awcrlpgkgs klqllmatgc qsglvcvwri
     3721 pqdttqtnvt saegwweqes ncqdgyrkss gakcvyqlrg hitpvrtvaf ssdglalvsg
     3781 glgglmniws lrdgsvlqtv vigsgaiqtt vwipevgvaa csnrskdvlv vnctaewaaa
     3841 nhvlatcrta lkqqgvlgln mapcmrafle rlpmmlqeqy ayekphvvcg dqlvhspymq
     3901 claslavglh ldqllcnppv pphhqnclpd paswnpnewa wlecfsttik aaealtngaq
     3961 fpesftvpdl epvpedelvf lmdnskwing mdeqimswat srpedwhlgg kcdvylwgag
     4021 rhgqlaeagr nvmvpaaaps fsqaqqvicg qnctfviqan gtvlacgegs ygrlgqgnsd
     4081 dlhvltvisa lqgfvvtqlv tscgsdghsm altesgevfs wgdgdygklg hgnsdrqrrp
     4141 rqiealqgee vvqmscgfkh savvtsdgkl ftfgngdygr lglgntsnkk lpervtaleg
     4201 yqigqvacgl nhtlavsadg smvwafgdgd ygklglgnst aksspqkidv lcgigikkva
     4261 cgtqfsvalt kdghvytfgq drliglpegr arnhnrpqqi pvlagviied vavgaehtla
     4321 lasngdvyaw gsnsegqlgl ghtnhvrept lvtglqgknv rqisagrchs aawtappvpp
     4381 rapgvsvplq lglpdtvppq ygalrevsih tvrarlrlly hfsdlmyssw rllnlspnnq
     4441 nstshynagt wgivqgqlrp llaprvytlp mvrsigktmv qgknygpqit vkristrgrk
     4501 ckpifvqiar qvvklnasdl rlpsrawkvk lvgegaddag gvfddtitem cqeletgivd
     4561 llipspnata evgynrdrfl fnpsacldeh lmqfkflgil mgvairtkkp ldlhlaplvw
     4621 kqlccvpltl edleevdlly vqtlnsilhi edsgiteesf hemipldsfv gqsadgkmvp
     4681 iipggnsipl tfsnrkeyve raieyrlhem drqvaavreg mswivpvpll slltakqleq
     4741 mvcgmpeisv evlkkvvryr evdeqhqlvq wfwhtleefs neervlfmrf vsgrsrlpan
     4801 tadisqrfqi mkvdrpydsl ptsqtcffql rlppyssqlv maerlryain ncrsidmdny
     4861 mlsrnvdnae gsdtdy
//
LOCUS       XP_047289197            4875 aa            linear   PRI 05-AUG-2025
DEFINITION  putative E3 ubiquitin-protein ligase HERC1 isoform X23 [Homo
            sapiens].
ACCESSION   XP_047289197
VERSION     XP_047289197.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433241.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4875
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4875
                     /product="putative E3 ubiquitin-protein ligase HERC1
                     isoform X23"
                     /calculated_mol_wt=533513
     Region          374..703
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          683..733
                     /region_name="RCC1"
                     /note="Regulator of chromosome condensation (RCC1) repeat;
                     pfam00415"
                     /db_xref="CDD:395335"
     Region          2032..2189
                     /region_name="SPRY_HERC1"
                     /note="SPRY domain in HERC1; cd12881"
                     /db_xref="CDD:293939"
     Region          2745..2788
                     /region_name="UBA_HERC1"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC1 and similar proteins; cd14401"
                     /db_xref="CDD:270584"
     Region          <3401..3792
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          3446..3489
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3503..3538
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3543..3590
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3599..3634
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3643..3679
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3686..3717
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3764..3800
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          4013..4349
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          4487..4855
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4492,4533,4544,4611,4789,4819..4820,4823..4827,4847,
                     4854)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4639,4642..4643,4645..4646,4649,4657,4659,
                     4663..4664,4666,4675,4680,4697,4701)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4875
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /coded_by="XM_047433241.1:149..14776"
                     /db_xref="GeneID:8925"
                     /db_xref="HGNC:HGNC:4867"
                     /db_xref="MIM:605109"
ORIGIN      
        1 matmippvkl kwlehlnssw itedsesiat regvavlysk lvsnkevvpl pqqvlclkgp
       61 qlpdferesl ssdeqdhyld allssqlala kmvcsdspfa galrkrllvl qrvfyalsnk
      121 yhdkgkvkqq qhspesssgs advhsvserp rsstdaliem gvrtglsllf allrqswmmp
      181 vsgpglslcn dvihtaievv sslpplslan eskippmgld clsqvttflk gvtipnsgad
      241 tlgrrlasel llglaaqrgs lryllewiem algasavvht mekgkllssq egmisfdcfm
      301 tilmqmrrsl gssadrsqwr eptrtsdglc slyeaalclf eevcrmasdy srtcaspdsi
      361 qtgdapivse tcevyvwgsn sshqlvegtq ekilqpklap sfsdaqtiea gqyctfvist
      421 dgsvracgkg sygrlglgds nnqstlkklt fephrsikkv ssskgsdght lafttegevf
      481 swgdgdygkl ghgnsstqky pkliqgplqg kvvvcvsagy rhsaavtedg elytwgegdf
      541 grlghgdsns rniptlvkdi snvgevscgs shtialskdg rtvwsfgggd ngklghgdtn
      601 rvykpkviea lqgmfirkvc agsqsslalt stgqvyawgc gaclgcgsse atalrpklie
      661 elaatrivdv sigdshclal shdnevyawg nnsmgqcgqg nstgpitkpk kvsgldgiai
      721 qqisagtshs lawtalprdr qvvawhrpyc vdleestfsh lrsflerycd kinseipplp
      781 fpssrehhsf lklclkllsn hlalalaggv atsilgrqag plrnllfrlm dstvpdeiqe
      841 vvietlsvga tmllpplrer mellhsllpq gpdrweslsk gqrmqldiil tslqdhthva
      901 sllgysspsd aadlssvctg ygnlsdqpyg tqschpdthl aeilmktllr nlgfytdqaf
      961 geleknsdkf llgtsssens qpahlhellc slqkqllafc hinnisenss svallhkhlq
     1021 lllphatdiy srsanllkes pwngsvgekl rdviyvsaag smlcqivnsl lllpvsvarp
     1081 llsylldllp pldclnrllp aadlledqel qwplhggpel idpaglplpq paqswvwlvd
     1141 lertiallig rclggmlqgs pvspeeqdta ywmktplfsd gvemdtpqld kcmsclleva
     1201 lsgneeqkpf dyklrpeiav yvdlalgcsk eparslwism qdyavskdwd satlsnesll
     1261 dtvsrfvlaa llkhtnllsq acgesryqpg khlsevyrcv ykvrsrllac knleliqtrs
     1321 ssrdrwisen qdsadvdpqe hsftrtidee aemeeqaerd reeghpeped eeeerehevm
     1381 tagkifqcfl sarevarsrd rdrmnsgags garaddpppq sqqerrvstd lpegqdvyta
     1441 acnsvihrca llilgvspvi delqkrreeg qlqqpstsas eggglmtrse sltaesrlvh
     1501 tspnyrliks rsesdlsqpe sdeegyalsg rrnvdldlaa shrkrgpmhs qleslsdswa
     1561 rlkhsrdwlc nssysfesdf dltkslgvht lienvvsfvs gdvgnapgfk epeesmstsp
     1621 qasiiameqq qlraelrlea lhqilvllsg meekgsisla gsrlssgfqs stlltsvrlq
     1681 flagcfglgt vghtggkges grlhhyqdgi raakrniqie iqvavhkiyq qlsatleral
     1741 qankhhieaq qrlllvtvfa lsvhyqpvdv slaistglln vlsqlcgtdt mlgqplqllp
     1801 ktgvsqlsta lkvastrllq ilaittgtya dklspkvvqs lldllcsqlk nllsqtgvlh
     1861 masfgegeqe dgeeeekkvd ssgetekkdf raalrkqhaa elhlgdflvf lrrvvsskai
     1921 qskmaspkwt evllniasqk cssgiplvgn lrtrllalhv leavlpaces gveddqmaqi
     1981 verlfsllsd cmwetpiaqa khaiqikeke qeiklqkqge leeedenlpi qevsfdpeka
     2041 qcclvengqi lthgsggkgy glastgvtsg cyqwkfyivk enrgnegtcv gvsrwpvhdf
     2101 nhrttsdmwl yraysgnlyh ngeqtltlss ftqgdfitcv ldmeartisf gkngeepkla
     2161 fedvdaaely pcvmfyssnp gekvkicdmq mrgtprdllp gdpicspvaa vlaeatiqli
     2221 rilhrtdrwt ycinkkmmer lhkikicike sgqklkksrs vqsreenemr eekeskeeek
     2281 gkhtrhglad lselqlrtlc ievwpvlavi ggvdaglrvg grcvhkqtgr hatllgvvke
     2341 gstsakvqwd eaeitisdtp lynlepcepl pfdvarfrgl tasvlldlty ltgvhedmgk
     2401 qstkrhekkh rheseekgdv eqkpesesal dmrtgltsdd vksqsttssk seneiasfsl
     2461 dptlpsvesq hqitegkrkn hehmsknhdv aqseiravql sylylgamks lsallgcsky
     2521 aelllipkvl aenghnsdca sspvvhedve mraalqflmr hmvkravmrs pikralglad
     2581 leraqamiyk lvvhglledq fggkikqeid qqaeesdpaq qaqtpvttsp sassttsfms
     2641 ssledtttat tpvtdtetvp asespgvmpl sllrqmfssy ptttvlptrr aqtppisslp
     2701 tspsdevgrr qsltspdsqs arpanrtals dpssrlstsp pppaiavpll emgfslrqia
     2761 kameatgarg eadaqnitvl amwmiehpgh edeeepqsgs tadsrpgaav lgsggksndp
     2821 cylqspgdip sadaaemeeg fsespdnldh tenaasgsgp sargrsavtr rhkfdlaart
     2881 llaraaglyr svqahrnqsr regislqqdp galydfnlde eleidlddea meamfgqdlt
     2941 sdndilgmwi pevldwptwh vcesedreev vvcelcecsv vsfnqhmkrn hpgcgrsanr
     3001 qgyrsngsyv dgwfggecgs gnpyyllcgt crekylamkt kskstssery kgqapdligk
     3061 qdsvyeedwd mldvdedekl tgeeefella gplglndrri vpepvqfpds dplgasvamv
     3121 tatnsmeetl mqielcfsgc hgsveksssg ritlgeqaaa lanphdrvva lrrvtaaaqv
     3181 llartmvmra lsllsvsgss cslaaglesl gltdirtlvr lmclaaagra glstspsama
     3241 stsersrggh skankpiscl aylstavgcl asnapsaakl lvqlctqnli saatgvnltt
     3301 vddsiqrkfl psflrgiaee nklvtspnfv vtqalvalla dkgaklrpny dksevekkgl
     3361 iaqlyahpsy dpsavgplel analaaccls srlssqhrqw aaqqlvrtla ahdrdnqttl
     3421 qtladmggdl rkcsfiklea hqnrvmtcvw cnkkgllats gndgtirvwn vtkkqyslqq
     3481 tcvfnrlegd aeeslgspsd psfspvswsi sgkylagale kmvniwqvng gkglvdiqph
     3541 wvsalawpee gpatawsges pelllvgrmd gslglievvd vstmhrrele hcyrkdvsvt
     3601 ciawfsedrp favgyfdgkl llgtkeplek ggivlidahk dtlismkwdp tghilmtcak
     3661 edsvklwgsi sgcwcclhsl chpsivngia wcrlpgkgsk lqllmatgcq sglvcvwrip
     3721 qdttqtnvts aegwweqesn cqdgyrkssg akcvyqlrgh itpvrtvafs sdglalvsgg
     3781 lgglmniwsl rdgsvlqtvv igsgaiqttv wipevgvaac snrskdvlvv nctaewaaan
     3841 hvlatcrtal kqqgvlglnm apcmrafler lpmmlqeqya yekphvvcgd qlvhspymqc
     3901 laslavglhl dqllcnppvp phhqnclpdp aswnpnewaw lecfsttika aealtngaqf
     3961 pesftvpdle pvpedelvfl mdnskwingm deqimswats rpedwhlggk cdvylwgagr
     4021 hgqlaeagrn vmvpaaapsf sqaqqvicgq nctfviqang tvlacgegsy grlgqgnsdd
     4081 lhvltvisal qgfvvtqlvt scgsdghsma ltesgevfsw gdgdygklgh gnsdrqrrpr
     4141 qiealqgeev vqmscgfkhs avvtsdgklf tfgngdygrl glgntsnkkl pervtalegy
     4201 qigqvacgln htlavsadgs mvwafgdgdy gklglgnsta ksspqkidvl cgigikkvac
     4261 gtqfsvaltk dghvytfgqd rliglpegra rnhnrpqqip vlagviiedv avgaehtlal
     4321 asngdvyawg snsegqlglg htnhvreptl vtglqgknvr qisagrchsa awtappvppr
     4381 apgvsvplql glpdtvppqy galrevsiht vrarlrllyh fsdlmysswr llnlspnnqn
     4441 stshynagtw givqgqlrpl laprvytlpm vrsigktmvq gknygpqitv kristrgrkc
     4501 kpifvqiarq vvklnasdlr lpsrawkvkl vgegaddagg vfddtitemc qeletgivdl
     4561 lipspnatae vgynrdrflf npsacldehl mqfkflgilm gvairtkkpl dlhlaplvwk
     4621 qlccvpltle dleevdllyv qtlnsilhie dsgiteesfh emipldsfvg qsadgkmvpi
     4681 ipggnsiplt fsnrkeyver aieyrlhemd rqvaavregm swivpvplls lltakqleqm
     4741 vcgmpeisve vlkkvvryre vdeqhqlvqw fwhtleefsn eervlfmrfv sgrsrlpant
     4801 adisqrfqim kvdrpydslp tsqtcffqlr lppyssqlvm aerlryainn crsidmdnym
     4861 lsrnvdnaeg sdtdy
//
LOCUS       XP_047289199            4875 aa            linear   PRI 05-AUG-2025
DEFINITION  putative E3 ubiquitin-protein ligase HERC1 isoform X23 [Homo
            sapiens].
ACCESSION   XP_047289199
VERSION     XP_047289199.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433243.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4875
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4875
                     /product="putative E3 ubiquitin-protein ligase HERC1
                     isoform X23"
                     /calculated_mol_wt=533513
     Region          374..703
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          683..733
                     /region_name="RCC1"
                     /note="Regulator of chromosome condensation (RCC1) repeat;
                     pfam00415"
                     /db_xref="CDD:395335"
     Region          2032..2189
                     /region_name="SPRY_HERC1"
                     /note="SPRY domain in HERC1; cd12881"
                     /db_xref="CDD:293939"
     Region          2745..2788
                     /region_name="UBA_HERC1"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC1 and similar proteins; cd14401"
                     /db_xref="CDD:270584"
     Region          <3401..3792
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          3446..3489
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3503..3538
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3543..3590
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3599..3634
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3643..3679
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3686..3717
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3764..3800
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          4013..4349
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          4487..4855
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4492,4533,4544,4611,4789,4819..4820,4823..4827,4847,
                     4854)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4639,4642..4643,4645..4646,4649,4657,4659,
                     4663..4664,4666,4675,4680,4697,4701)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4875
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /coded_by="XM_047433243.1:154..14781"
                     /db_xref="GeneID:8925"
                     /db_xref="HGNC:HGNC:4867"
                     /db_xref="MIM:605109"
ORIGIN      
        1 matmippvkl kwlehlnssw itedsesiat regvavlysk lvsnkevvpl pqqvlclkgp
       61 qlpdferesl ssdeqdhyld allssqlala kmvcsdspfa galrkrllvl qrvfyalsnk
      121 yhdkgkvkqq qhspesssgs advhsvserp rsstdaliem gvrtglsllf allrqswmmp
      181 vsgpglslcn dvihtaievv sslpplslan eskippmgld clsqvttflk gvtipnsgad
      241 tlgrrlasel llglaaqrgs lryllewiem algasavvht mekgkllssq egmisfdcfm
      301 tilmqmrrsl gssadrsqwr eptrtsdglc slyeaalclf eevcrmasdy srtcaspdsi
      361 qtgdapivse tcevyvwgsn sshqlvegtq ekilqpklap sfsdaqtiea gqyctfvist
      421 dgsvracgkg sygrlglgds nnqstlkklt fephrsikkv ssskgsdght lafttegevf
      481 swgdgdygkl ghgnsstqky pkliqgplqg kvvvcvsagy rhsaavtedg elytwgegdf
      541 grlghgdsns rniptlvkdi snvgevscgs shtialskdg rtvwsfgggd ngklghgdtn
      601 rvykpkviea lqgmfirkvc agsqsslalt stgqvyawgc gaclgcgsse atalrpklie
      661 elaatrivdv sigdshclal shdnevyawg nnsmgqcgqg nstgpitkpk kvsgldgiai
      721 qqisagtshs lawtalprdr qvvawhrpyc vdleestfsh lrsflerycd kinseipplp
      781 fpssrehhsf lklclkllsn hlalalaggv atsilgrqag plrnllfrlm dstvpdeiqe
      841 vvietlsvga tmllpplrer mellhsllpq gpdrweslsk gqrmqldiil tslqdhthva
      901 sllgysspsd aadlssvctg ygnlsdqpyg tqschpdthl aeilmktllr nlgfytdqaf
      961 geleknsdkf llgtsssens qpahlhellc slqkqllafc hinnisenss svallhkhlq
     1021 lllphatdiy srsanllkes pwngsvgekl rdviyvsaag smlcqivnsl lllpvsvarp
     1081 llsylldllp pldclnrllp aadlledqel qwplhggpel idpaglplpq paqswvwlvd
     1141 lertiallig rclggmlqgs pvspeeqdta ywmktplfsd gvemdtpqld kcmsclleva
     1201 lsgneeqkpf dyklrpeiav yvdlalgcsk eparslwism qdyavskdwd satlsnesll
     1261 dtvsrfvlaa llkhtnllsq acgesryqpg khlsevyrcv ykvrsrllac knleliqtrs
     1321 ssrdrwisen qdsadvdpqe hsftrtidee aemeeqaerd reeghpeped eeeerehevm
     1381 tagkifqcfl sarevarsrd rdrmnsgags garaddpppq sqqerrvstd lpegqdvyta
     1441 acnsvihrca llilgvspvi delqkrreeg qlqqpstsas eggglmtrse sltaesrlvh
     1501 tspnyrliks rsesdlsqpe sdeegyalsg rrnvdldlaa shrkrgpmhs qleslsdswa
     1561 rlkhsrdwlc nssysfesdf dltkslgvht lienvvsfvs gdvgnapgfk epeesmstsp
     1621 qasiiameqq qlraelrlea lhqilvllsg meekgsisla gsrlssgfqs stlltsvrlq
     1681 flagcfglgt vghtggkges grlhhyqdgi raakrniqie iqvavhkiyq qlsatleral
     1741 qankhhieaq qrlllvtvfa lsvhyqpvdv slaistglln vlsqlcgtdt mlgqplqllp
     1801 ktgvsqlsta lkvastrllq ilaittgtya dklspkvvqs lldllcsqlk nllsqtgvlh
     1861 masfgegeqe dgeeeekkvd ssgetekkdf raalrkqhaa elhlgdflvf lrrvvsskai
     1921 qskmaspkwt evllniasqk cssgiplvgn lrtrllalhv leavlpaces gveddqmaqi
     1981 verlfsllsd cmwetpiaqa khaiqikeke qeiklqkqge leeedenlpi qevsfdpeka
     2041 qcclvengqi lthgsggkgy glastgvtsg cyqwkfyivk enrgnegtcv gvsrwpvhdf
     2101 nhrttsdmwl yraysgnlyh ngeqtltlss ftqgdfitcv ldmeartisf gkngeepkla
     2161 fedvdaaely pcvmfyssnp gekvkicdmq mrgtprdllp gdpicspvaa vlaeatiqli
     2221 rilhrtdrwt ycinkkmmer lhkikicike sgqklkksrs vqsreenemr eekeskeeek
     2281 gkhtrhglad lselqlrtlc ievwpvlavi ggvdaglrvg grcvhkqtgr hatllgvvke
     2341 gstsakvqwd eaeitisdtp lynlepcepl pfdvarfrgl tasvlldlty ltgvhedmgk
     2401 qstkrhekkh rheseekgdv eqkpesesal dmrtgltsdd vksqsttssk seneiasfsl
     2461 dptlpsvesq hqitegkrkn hehmsknhdv aqseiravql sylylgamks lsallgcsky
     2521 aelllipkvl aenghnsdca sspvvhedve mraalqflmr hmvkravmrs pikralglad
     2581 leraqamiyk lvvhglledq fggkikqeid qqaeesdpaq qaqtpvttsp sassttsfms
     2641 ssledtttat tpvtdtetvp asespgvmpl sllrqmfssy ptttvlptrr aqtppisslp
     2701 tspsdevgrr qsltspdsqs arpanrtals dpssrlstsp pppaiavpll emgfslrqia
     2761 kameatgarg eadaqnitvl amwmiehpgh edeeepqsgs tadsrpgaav lgsggksndp
     2821 cylqspgdip sadaaemeeg fsespdnldh tenaasgsgp sargrsavtr rhkfdlaart
     2881 llaraaglyr svqahrnqsr regislqqdp galydfnlde eleidlddea meamfgqdlt
     2941 sdndilgmwi pevldwptwh vcesedreev vvcelcecsv vsfnqhmkrn hpgcgrsanr
     3001 qgyrsngsyv dgwfggecgs gnpyyllcgt crekylamkt kskstssery kgqapdligk
     3061 qdsvyeedwd mldvdedekl tgeeefella gplglndrri vpepvqfpds dplgasvamv
     3121 tatnsmeetl mqielcfsgc hgsveksssg ritlgeqaaa lanphdrvva lrrvtaaaqv
     3181 llartmvmra lsllsvsgss cslaaglesl gltdirtlvr lmclaaagra glstspsama
     3241 stsersrggh skankpiscl aylstavgcl asnapsaakl lvqlctqnli saatgvnltt
     3301 vddsiqrkfl psflrgiaee nklvtspnfv vtqalvalla dkgaklrpny dksevekkgl
     3361 iaqlyahpsy dpsavgplel analaaccls srlssqhrqw aaqqlvrtla ahdrdnqttl
     3421 qtladmggdl rkcsfiklea hqnrvmtcvw cnkkgllats gndgtirvwn vtkkqyslqq
     3481 tcvfnrlegd aeeslgspsd psfspvswsi sgkylagale kmvniwqvng gkglvdiqph
     3541 wvsalawpee gpatawsges pelllvgrmd gslglievvd vstmhrrele hcyrkdvsvt
     3601 ciawfsedrp favgyfdgkl llgtkeplek ggivlidahk dtlismkwdp tghilmtcak
     3661 edsvklwgsi sgcwcclhsl chpsivngia wcrlpgkgsk lqllmatgcq sglvcvwrip
     3721 qdttqtnvts aegwweqesn cqdgyrkssg akcvyqlrgh itpvrtvafs sdglalvsgg
     3781 lgglmniwsl rdgsvlqtvv igsgaiqttv wipevgvaac snrskdvlvv nctaewaaan
     3841 hvlatcrtal kqqgvlglnm apcmrafler lpmmlqeqya yekphvvcgd qlvhspymqc
     3901 laslavglhl dqllcnppvp phhqnclpdp aswnpnewaw lecfsttika aealtngaqf
     3961 pesftvpdle pvpedelvfl mdnskwingm deqimswats rpedwhlggk cdvylwgagr
     4021 hgqlaeagrn vmvpaaapsf sqaqqvicgq nctfviqang tvlacgegsy grlgqgnsdd
     4081 lhvltvisal qgfvvtqlvt scgsdghsma ltesgevfsw gdgdygklgh gnsdrqrrpr
     4141 qiealqgeev vqmscgfkhs avvtsdgklf tfgngdygrl glgntsnkkl pervtalegy
     4201 qigqvacgln htlavsadgs mvwafgdgdy gklglgnsta ksspqkidvl cgigikkvac
     4261 gtqfsvaltk dghvytfgqd rliglpegra rnhnrpqqip vlagviiedv avgaehtlal
     4321 asngdvyawg snsegqlglg htnhvreptl vtglqgknvr qisagrchsa awtappvppr
     4381 apgvsvplql glpdtvppqy galrevsiht vrarlrllyh fsdlmysswr llnlspnnqn
     4441 stshynagtw givqgqlrpl laprvytlpm vrsigktmvq gknygpqitv kristrgrkc
     4501 kpifvqiarq vvklnasdlr lpsrawkvkl vgegaddagg vfddtitemc qeletgivdl
     4561 lipspnatae vgynrdrflf npsacldehl mqfkflgilm gvairtkkpl dlhlaplvwk
     4621 qlccvpltle dleevdllyv qtlnsilhie dsgiteesfh emipldsfvg qsadgkmvpi
     4681 ipggnsiplt fsnrkeyver aieyrlhemd rqvaavregm swivpvplls lltakqleqm
     4741 vcgmpeisve vlkkvvryre vdeqhqlvqw fwhtleefsn eervlfmrfv sgrsrlpant
     4801 adisqrfqim kvdrpydslp tsqtcffqlr lppyssqlvm aerlryainn crsidmdnym
     4861 lsrnvdnaeg sdtdy
//
LOCUS       XP_047289200            4875 aa            linear   PRI 05-AUG-2025
DEFINITION  putative E3 ubiquitin-protein ligase HERC1 isoform X23 [Homo
            sapiens].
ACCESSION   XP_047289200
VERSION     XP_047289200.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433244.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4875
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4875
                     /product="putative E3 ubiquitin-protein ligase HERC1
                     isoform X23"
                     /calculated_mol_wt=533513
     Region          374..703
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          683..733
                     /region_name="RCC1"
                     /note="Regulator of chromosome condensation (RCC1) repeat;
                     pfam00415"
                     /db_xref="CDD:395335"
     Region          2032..2189
                     /region_name="SPRY_HERC1"
                     /note="SPRY domain in HERC1; cd12881"
                     /db_xref="CDD:293939"
     Region          2745..2788
                     /region_name="UBA_HERC1"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC1 and similar proteins; cd14401"
                     /db_xref="CDD:270584"
     Region          <3401..3792
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          3446..3489
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3503..3538
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3543..3590
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3599..3634
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3643..3679
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3686..3717
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3764..3800
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          4013..4349
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          4487..4855
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4492,4533,4544,4611,4789,4819..4820,4823..4827,4847,
                     4854)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4639,4642..4643,4645..4646,4649,4657,4659,
                     4663..4664,4666,4675,4680,4697,4701)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4875
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /coded_by="XM_047433244.1:474..15101"
                     /db_xref="GeneID:8925"
                     /db_xref="HGNC:HGNC:4867"
                     /db_xref="MIM:605109"
ORIGIN      
        1 matmippvkl kwlehlnssw itedsesiat regvavlysk lvsnkevvpl pqqvlclkgp
       61 qlpdferesl ssdeqdhyld allssqlala kmvcsdspfa galrkrllvl qrvfyalsnk
      121 yhdkgkvkqq qhspesssgs advhsvserp rsstdaliem gvrtglsllf allrqswmmp
      181 vsgpglslcn dvihtaievv sslpplslan eskippmgld clsqvttflk gvtipnsgad
      241 tlgrrlasel llglaaqrgs lryllewiem algasavvht mekgkllssq egmisfdcfm
      301 tilmqmrrsl gssadrsqwr eptrtsdglc slyeaalclf eevcrmasdy srtcaspdsi
      361 qtgdapivse tcevyvwgsn sshqlvegtq ekilqpklap sfsdaqtiea gqyctfvist
      421 dgsvracgkg sygrlglgds nnqstlkklt fephrsikkv ssskgsdght lafttegevf
      481 swgdgdygkl ghgnsstqky pkliqgplqg kvvvcvsagy rhsaavtedg elytwgegdf
      541 grlghgdsns rniptlvkdi snvgevscgs shtialskdg rtvwsfgggd ngklghgdtn
      601 rvykpkviea lqgmfirkvc agsqsslalt stgqvyawgc gaclgcgsse atalrpklie
      661 elaatrivdv sigdshclal shdnevyawg nnsmgqcgqg nstgpitkpk kvsgldgiai
      721 qqisagtshs lawtalprdr qvvawhrpyc vdleestfsh lrsflerycd kinseipplp
      781 fpssrehhsf lklclkllsn hlalalaggv atsilgrqag plrnllfrlm dstvpdeiqe
      841 vvietlsvga tmllpplrer mellhsllpq gpdrweslsk gqrmqldiil tslqdhthva
      901 sllgysspsd aadlssvctg ygnlsdqpyg tqschpdthl aeilmktllr nlgfytdqaf
      961 geleknsdkf llgtsssens qpahlhellc slqkqllafc hinnisenss svallhkhlq
     1021 lllphatdiy srsanllkes pwngsvgekl rdviyvsaag smlcqivnsl lllpvsvarp
     1081 llsylldllp pldclnrllp aadlledqel qwplhggpel idpaglplpq paqswvwlvd
     1141 lertiallig rclggmlqgs pvspeeqdta ywmktplfsd gvemdtpqld kcmsclleva
     1201 lsgneeqkpf dyklrpeiav yvdlalgcsk eparslwism qdyavskdwd satlsnesll
     1261 dtvsrfvlaa llkhtnllsq acgesryqpg khlsevyrcv ykvrsrllac knleliqtrs
     1321 ssrdrwisen qdsadvdpqe hsftrtidee aemeeqaerd reeghpeped eeeerehevm
     1381 tagkifqcfl sarevarsrd rdrmnsgags garaddpppq sqqerrvstd lpegqdvyta
     1441 acnsvihrca llilgvspvi delqkrreeg qlqqpstsas eggglmtrse sltaesrlvh
     1501 tspnyrliks rsesdlsqpe sdeegyalsg rrnvdldlaa shrkrgpmhs qleslsdswa
     1561 rlkhsrdwlc nssysfesdf dltkslgvht lienvvsfvs gdvgnapgfk epeesmstsp
     1621 qasiiameqq qlraelrlea lhqilvllsg meekgsisla gsrlssgfqs stlltsvrlq
     1681 flagcfglgt vghtggkges grlhhyqdgi raakrniqie iqvavhkiyq qlsatleral
     1741 qankhhieaq qrlllvtvfa lsvhyqpvdv slaistglln vlsqlcgtdt mlgqplqllp
     1801 ktgvsqlsta lkvastrllq ilaittgtya dklspkvvqs lldllcsqlk nllsqtgvlh
     1861 masfgegeqe dgeeeekkvd ssgetekkdf raalrkqhaa elhlgdflvf lrrvvsskai
     1921 qskmaspkwt evllniasqk cssgiplvgn lrtrllalhv leavlpaces gveddqmaqi
     1981 verlfsllsd cmwetpiaqa khaiqikeke qeiklqkqge leeedenlpi qevsfdpeka
     2041 qcclvengqi lthgsggkgy glastgvtsg cyqwkfyivk enrgnegtcv gvsrwpvhdf
     2101 nhrttsdmwl yraysgnlyh ngeqtltlss ftqgdfitcv ldmeartisf gkngeepkla
     2161 fedvdaaely pcvmfyssnp gekvkicdmq mrgtprdllp gdpicspvaa vlaeatiqli
     2221 rilhrtdrwt ycinkkmmer lhkikicike sgqklkksrs vqsreenemr eekeskeeek
     2281 gkhtrhglad lselqlrtlc ievwpvlavi ggvdaglrvg grcvhkqtgr hatllgvvke
     2341 gstsakvqwd eaeitisdtp lynlepcepl pfdvarfrgl tasvlldlty ltgvhedmgk
     2401 qstkrhekkh rheseekgdv eqkpesesal dmrtgltsdd vksqsttssk seneiasfsl
     2461 dptlpsvesq hqitegkrkn hehmsknhdv aqseiravql sylylgamks lsallgcsky
     2521 aelllipkvl aenghnsdca sspvvhedve mraalqflmr hmvkravmrs pikralglad
     2581 leraqamiyk lvvhglledq fggkikqeid qqaeesdpaq qaqtpvttsp sassttsfms
     2641 ssledtttat tpvtdtetvp asespgvmpl sllrqmfssy ptttvlptrr aqtppisslp
     2701 tspsdevgrr qsltspdsqs arpanrtals dpssrlstsp pppaiavpll emgfslrqia
     2761 kameatgarg eadaqnitvl amwmiehpgh edeeepqsgs tadsrpgaav lgsggksndp
     2821 cylqspgdip sadaaemeeg fsespdnldh tenaasgsgp sargrsavtr rhkfdlaart
     2881 llaraaglyr svqahrnqsr regislqqdp galydfnlde eleidlddea meamfgqdlt
     2941 sdndilgmwi pevldwptwh vcesedreev vvcelcecsv vsfnqhmkrn hpgcgrsanr
     3001 qgyrsngsyv dgwfggecgs gnpyyllcgt crekylamkt kskstssery kgqapdligk
     3061 qdsvyeedwd mldvdedekl tgeeefella gplglndrri vpepvqfpds dplgasvamv
     3121 tatnsmeetl mqielcfsgc hgsveksssg ritlgeqaaa lanphdrvva lrrvtaaaqv
     3181 llartmvmra lsllsvsgss cslaaglesl gltdirtlvr lmclaaagra glstspsama
     3241 stsersrggh skankpiscl aylstavgcl asnapsaakl lvqlctqnli saatgvnltt
     3301 vddsiqrkfl psflrgiaee nklvtspnfv vtqalvalla dkgaklrpny dksevekkgl
     3361 iaqlyahpsy dpsavgplel analaaccls srlssqhrqw aaqqlvrtla ahdrdnqttl
     3421 qtladmggdl rkcsfiklea hqnrvmtcvw cnkkgllats gndgtirvwn vtkkqyslqq
     3481 tcvfnrlegd aeeslgspsd psfspvswsi sgkylagale kmvniwqvng gkglvdiqph
     3541 wvsalawpee gpatawsges pelllvgrmd gslglievvd vstmhrrele hcyrkdvsvt
     3601 ciawfsedrp favgyfdgkl llgtkeplek ggivlidahk dtlismkwdp tghilmtcak
     3661 edsvklwgsi sgcwcclhsl chpsivngia wcrlpgkgsk lqllmatgcq sglvcvwrip
     3721 qdttqtnvts aegwweqesn cqdgyrkssg akcvyqlrgh itpvrtvafs sdglalvsgg
     3781 lgglmniwsl rdgsvlqtvv igsgaiqttv wipevgvaac snrskdvlvv nctaewaaan
     3841 hvlatcrtal kqqgvlglnm apcmrafler lpmmlqeqya yekphvvcgd qlvhspymqc
     3901 laslavglhl dqllcnppvp phhqnclpdp aswnpnewaw lecfsttika aealtngaqf
     3961 pesftvpdle pvpedelvfl mdnskwingm deqimswats rpedwhlggk cdvylwgagr
     4021 hgqlaeagrn vmvpaaapsf sqaqqvicgq nctfviqang tvlacgegsy grlgqgnsdd
     4081 lhvltvisal qgfvvtqlvt scgsdghsma ltesgevfsw gdgdygklgh gnsdrqrrpr
     4141 qiealqgeev vqmscgfkhs avvtsdgklf tfgngdygrl glgntsnkkl pervtalegy
     4201 qigqvacgln htlavsadgs mvwafgdgdy gklglgnsta ksspqkidvl cgigikkvac
     4261 gtqfsvaltk dghvytfgqd rliglpegra rnhnrpqqip vlagviiedv avgaehtlal
     4321 asngdvyawg snsegqlglg htnhvreptl vtglqgknvr qisagrchsa awtappvppr
     4381 apgvsvplql glpdtvppqy galrevsiht vrarlrllyh fsdlmysswr llnlspnnqn
     4441 stshynagtw givqgqlrpl laprvytlpm vrsigktmvq gknygpqitv kristrgrkc
     4501 kpifvqiarq vvklnasdlr lpsrawkvkl vgegaddagg vfddtitemc qeletgivdl
     4561 lipspnatae vgynrdrflf npsacldehl mqfkflgilm gvairtkkpl dlhlaplvwk
     4621 qlccvpltle dleevdllyv qtlnsilhie dsgiteesfh emipldsfvg qsadgkmvpi
     4681 ipggnsiplt fsnrkeyver aieyrlhemd rqvaavregm swivpvplls lltakqleqm
     4741 vcgmpeisve vlkkvvryre vdeqhqlvqw fwhtleefsn eervlfmrfv sgrsrlpant
     4801 adisqrfqim kvdrpydslp tsqtcffqlr lppyssqlvm aerlryainn crsidmdnym
     4861 lsrnvdnaeg sdtdy
//
LOCUS       XP_047289201            4875 aa            linear   PRI 05-AUG-2025
DEFINITION  putative E3 ubiquitin-protein ligase HERC1 isoform X23 [Homo
            sapiens].
ACCESSION   XP_047289201
VERSION     XP_047289201.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433245.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4875
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4875
                     /product="putative E3 ubiquitin-protein ligase HERC1
                     isoform X23"
                     /calculated_mol_wt=533513
     Region          374..703
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          683..733
                     /region_name="RCC1"
                     /note="Regulator of chromosome condensation (RCC1) repeat;
                     pfam00415"
                     /db_xref="CDD:395335"
     Region          2032..2189
                     /region_name="SPRY_HERC1"
                     /note="SPRY domain in HERC1; cd12881"
                     /db_xref="CDD:293939"
     Region          2745..2788
                     /region_name="UBA_HERC1"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC1 and similar proteins; cd14401"
                     /db_xref="CDD:270584"
     Region          <3401..3792
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          3446..3489
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3503..3538
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3543..3590
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3599..3634
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3643..3679
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3686..3717
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3764..3800
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          4013..4349
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          4487..4855
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4492,4533,4544,4611,4789,4819..4820,4823..4827,4847,
                     4854)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4639,4642..4643,4645..4646,4649,4657,4659,
                     4663..4664,4666,4675,4680,4697,4701)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4875
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /coded_by="XM_047433245.1:3471..18098"
                     /db_xref="GeneID:8925"
                     /db_xref="HGNC:HGNC:4867"
                     /db_xref="MIM:605109"
ORIGIN      
        1 matmippvkl kwlehlnssw itedsesiat regvavlysk lvsnkevvpl pqqvlclkgp
       61 qlpdferesl ssdeqdhyld allssqlala kmvcsdspfa galrkrllvl qrvfyalsnk
      121 yhdkgkvkqq qhspesssgs advhsvserp rsstdaliem gvrtglsllf allrqswmmp
      181 vsgpglslcn dvihtaievv sslpplslan eskippmgld clsqvttflk gvtipnsgad
      241 tlgrrlasel llglaaqrgs lryllewiem algasavvht mekgkllssq egmisfdcfm
      301 tilmqmrrsl gssadrsqwr eptrtsdglc slyeaalclf eevcrmasdy srtcaspdsi
      361 qtgdapivse tcevyvwgsn sshqlvegtq ekilqpklap sfsdaqtiea gqyctfvist
      421 dgsvracgkg sygrlglgds nnqstlkklt fephrsikkv ssskgsdght lafttegevf
      481 swgdgdygkl ghgnsstqky pkliqgplqg kvvvcvsagy rhsaavtedg elytwgegdf
      541 grlghgdsns rniptlvkdi snvgevscgs shtialskdg rtvwsfgggd ngklghgdtn
      601 rvykpkviea lqgmfirkvc agsqsslalt stgqvyawgc gaclgcgsse atalrpklie
      661 elaatrivdv sigdshclal shdnevyawg nnsmgqcgqg nstgpitkpk kvsgldgiai
      721 qqisagtshs lawtalprdr qvvawhrpyc vdleestfsh lrsflerycd kinseipplp
      781 fpssrehhsf lklclkllsn hlalalaggv atsilgrqag plrnllfrlm dstvpdeiqe
      841 vvietlsvga tmllpplrer mellhsllpq gpdrweslsk gqrmqldiil tslqdhthva
      901 sllgysspsd aadlssvctg ygnlsdqpyg tqschpdthl aeilmktllr nlgfytdqaf
      961 geleknsdkf llgtsssens qpahlhellc slqkqllafc hinnisenss svallhkhlq
     1021 lllphatdiy srsanllkes pwngsvgekl rdviyvsaag smlcqivnsl lllpvsvarp
     1081 llsylldllp pldclnrllp aadlledqel qwplhggpel idpaglplpq paqswvwlvd
     1141 lertiallig rclggmlqgs pvspeeqdta ywmktplfsd gvemdtpqld kcmsclleva
     1201 lsgneeqkpf dyklrpeiav yvdlalgcsk eparslwism qdyavskdwd satlsnesll
     1261 dtvsrfvlaa llkhtnllsq acgesryqpg khlsevyrcv ykvrsrllac knleliqtrs
     1321 ssrdrwisen qdsadvdpqe hsftrtidee aemeeqaerd reeghpeped eeeerehevm
     1381 tagkifqcfl sarevarsrd rdrmnsgags garaddpppq sqqerrvstd lpegqdvyta
     1441 acnsvihrca llilgvspvi delqkrreeg qlqqpstsas eggglmtrse sltaesrlvh
     1501 tspnyrliks rsesdlsqpe sdeegyalsg rrnvdldlaa shrkrgpmhs qleslsdswa
     1561 rlkhsrdwlc nssysfesdf dltkslgvht lienvvsfvs gdvgnapgfk epeesmstsp
     1621 qasiiameqq qlraelrlea lhqilvllsg meekgsisla gsrlssgfqs stlltsvrlq
     1681 flagcfglgt vghtggkges grlhhyqdgi raakrniqie iqvavhkiyq qlsatleral
     1741 qankhhieaq qrlllvtvfa lsvhyqpvdv slaistglln vlsqlcgtdt mlgqplqllp
     1801 ktgvsqlsta lkvastrllq ilaittgtya dklspkvvqs lldllcsqlk nllsqtgvlh
     1861 masfgegeqe dgeeeekkvd ssgetekkdf raalrkqhaa elhlgdflvf lrrvvsskai
     1921 qskmaspkwt evllniasqk cssgiplvgn lrtrllalhv leavlpaces gveddqmaqi
     1981 verlfsllsd cmwetpiaqa khaiqikeke qeiklqkqge leeedenlpi qevsfdpeka
     2041 qcclvengqi lthgsggkgy glastgvtsg cyqwkfyivk enrgnegtcv gvsrwpvhdf
     2101 nhrttsdmwl yraysgnlyh ngeqtltlss ftqgdfitcv ldmeartisf gkngeepkla
     2161 fedvdaaely pcvmfyssnp gekvkicdmq mrgtprdllp gdpicspvaa vlaeatiqli
     2221 rilhrtdrwt ycinkkmmer lhkikicike sgqklkksrs vqsreenemr eekeskeeek
     2281 gkhtrhglad lselqlrtlc ievwpvlavi ggvdaglrvg grcvhkqtgr hatllgvvke
     2341 gstsakvqwd eaeitisdtp lynlepcepl pfdvarfrgl tasvlldlty ltgvhedmgk
     2401 qstkrhekkh rheseekgdv eqkpesesal dmrtgltsdd vksqsttssk seneiasfsl
     2461 dptlpsvesq hqitegkrkn hehmsknhdv aqseiravql sylylgamks lsallgcsky
     2521 aelllipkvl aenghnsdca sspvvhedve mraalqflmr hmvkravmrs pikralglad
     2581 leraqamiyk lvvhglledq fggkikqeid qqaeesdpaq qaqtpvttsp sassttsfms
     2641 ssledtttat tpvtdtetvp asespgvmpl sllrqmfssy ptttvlptrr aqtppisslp
     2701 tspsdevgrr qsltspdsqs arpanrtals dpssrlstsp pppaiavpll emgfslrqia
     2761 kameatgarg eadaqnitvl amwmiehpgh edeeepqsgs tadsrpgaav lgsggksndp
     2821 cylqspgdip sadaaemeeg fsespdnldh tenaasgsgp sargrsavtr rhkfdlaart
     2881 llaraaglyr svqahrnqsr regislqqdp galydfnlde eleidlddea meamfgqdlt
     2941 sdndilgmwi pevldwptwh vcesedreev vvcelcecsv vsfnqhmkrn hpgcgrsanr
     3001 qgyrsngsyv dgwfggecgs gnpyyllcgt crekylamkt kskstssery kgqapdligk
     3061 qdsvyeedwd mldvdedekl tgeeefella gplglndrri vpepvqfpds dplgasvamv
     3121 tatnsmeetl mqielcfsgc hgsveksssg ritlgeqaaa lanphdrvva lrrvtaaaqv
     3181 llartmvmra lsllsvsgss cslaaglesl gltdirtlvr lmclaaagra glstspsama
     3241 stsersrggh skankpiscl aylstavgcl asnapsaakl lvqlctqnli saatgvnltt
     3301 vddsiqrkfl psflrgiaee nklvtspnfv vtqalvalla dkgaklrpny dksevekkgl
     3361 iaqlyahpsy dpsavgplel analaaccls srlssqhrqw aaqqlvrtla ahdrdnqttl
     3421 qtladmggdl rkcsfiklea hqnrvmtcvw cnkkgllats gndgtirvwn vtkkqyslqq
     3481 tcvfnrlegd aeeslgspsd psfspvswsi sgkylagale kmvniwqvng gkglvdiqph
     3541 wvsalawpee gpatawsges pelllvgrmd gslglievvd vstmhrrele hcyrkdvsvt
     3601 ciawfsedrp favgyfdgkl llgtkeplek ggivlidahk dtlismkwdp tghilmtcak
     3661 edsvklwgsi sgcwcclhsl chpsivngia wcrlpgkgsk lqllmatgcq sglvcvwrip
     3721 qdttqtnvts aegwweqesn cqdgyrkssg akcvyqlrgh itpvrtvafs sdglalvsgg
     3781 lgglmniwsl rdgsvlqtvv igsgaiqttv wipevgvaac snrskdvlvv nctaewaaan
     3841 hvlatcrtal kqqgvlglnm apcmrafler lpmmlqeqya yekphvvcgd qlvhspymqc
     3901 laslavglhl dqllcnppvp phhqnclpdp aswnpnewaw lecfsttika aealtngaqf
     3961 pesftvpdle pvpedelvfl mdnskwingm deqimswats rpedwhlggk cdvylwgagr
     4021 hgqlaeagrn vmvpaaapsf sqaqqvicgq nctfviqang tvlacgegsy grlgqgnsdd
     4081 lhvltvisal qgfvvtqlvt scgsdghsma ltesgevfsw gdgdygklgh gnsdrqrrpr
     4141 qiealqgeev vqmscgfkhs avvtsdgklf tfgngdygrl glgntsnkkl pervtalegy
     4201 qigqvacgln htlavsadgs mvwafgdgdy gklglgnsta ksspqkidvl cgigikkvac
     4261 gtqfsvaltk dghvytfgqd rliglpegra rnhnrpqqip vlagviiedv avgaehtlal
     4321 asngdvyawg snsegqlglg htnhvreptl vtglqgknvr qisagrchsa awtappvppr
     4381 apgvsvplql glpdtvppqy galrevsiht vrarlrllyh fsdlmysswr llnlspnnqn
     4441 stshynagtw givqgqlrpl laprvytlpm vrsigktmvq gknygpqitv kristrgrkc
     4501 kpifvqiarq vvklnasdlr lpsrawkvkl vgegaddagg vfddtitemc qeletgivdl
     4561 lipspnatae vgynrdrflf npsacldehl mqfkflgilm gvairtkkpl dlhlaplvwk
     4621 qlccvpltle dleevdllyv qtlnsilhie dsgiteesfh emipldsfvg qsadgkmvpi
     4681 ipggnsiplt fsnrkeyver aieyrlhemd rqvaavregm swivpvplls lltakqleqm
     4741 vcgmpeisve vlkkvvryre vdeqhqlvqw fwhtleefsn eervlfmrfv sgrsrlpant
     4801 adisqrfqim kvdrpydslp tsqtcffqlr lppyssqlvm aerlryainn crsidmdnym
     4861 lsrnvdnaeg sdtdy
//
LOCUS       XP_047289202            4874 aa            linear   PRI 05-AUG-2025
DEFINITION  putative E3 ubiquitin-protein ligase HERC1 isoform X24 [Homo
            sapiens].
ACCESSION   XP_047289202
VERSION     XP_047289202.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433246.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4874
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4874
                     /product="putative E3 ubiquitin-protein ligase HERC1
                     isoform X24"
                     /calculated_mol_wt=533385
     Region          374..703
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          683..733
                     /region_name="RCC1"
                     /note="Regulator of chromosome condensation (RCC1) repeat;
                     pfam00415"
                     /db_xref="CDD:395335"
     Region          2031..2188
                     /region_name="SPRY_HERC1"
                     /note="SPRY domain in HERC1; cd12881"
                     /db_xref="CDD:293939"
     Region          2744..2787
                     /region_name="UBA_HERC1"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC1 and similar proteins; cd14401"
                     /db_xref="CDD:270584"
     Region          <3400..3791
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          3445..3488
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3502..3537
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3542..3589
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3598..3633
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3642..3678
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3685..3716
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3763..3799
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          4012..4348
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          4486..4854
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4491,4532,4543,4610,4788,4818..4819,4822..4826,4846,
                     4853)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4638,4641..4642,4644..4645,4648,4656,4658,
                     4662..4663,4665,4674,4679,4696,4700)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4874
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /coded_by="XM_047433246.1:154..14778"
                     /db_xref="GeneID:8925"
                     /db_xref="HGNC:HGNC:4867"
                     /db_xref="MIM:605109"
ORIGIN      
        1 matmippvkl kwlehlnssw itedsesiat regvavlysk lvsnkevvpl pqqvlclkgp
       61 qlpdferesl ssdeqdhyld allssqlala kmvcsdspfa galrkrllvl qrvfyalsnk
      121 yhdkgkvkqq qhspesssgs advhsvserp rsstdaliem gvrtglsllf allrqswmmp
      181 vsgpglslcn dvihtaievv sslpplslan eskippmgld clsqvttflk gvtipnsgad
      241 tlgrrlasel llglaaqrgs lryllewiem algasavvht mekgkllssq egmisfdcfm
      301 tilmqmrrsl gssadrsqwr eptrtsdglc slyeaalclf eevcrmasdy srtcaspdsi
      361 qtgdapivse tcevyvwgsn sshqlvegtq ekilqpklap sfsdaqtiea gqyctfvist
      421 dgsvracgkg sygrlglgds nnqstlkklt fephrsikkv ssskgsdght lafttegevf
      481 swgdgdygkl ghgnsstqky pkliqgplqg kvvvcvsagy rhsaavtedg elytwgegdf
      541 grlghgdsns rniptlvkdi snvgevscgs shtialskdg rtvwsfgggd ngklghgdtn
      601 rvykpkviea lqgmfirkvc agsqsslalt stgqvyawgc gaclgcgsse atalrpklie
      661 elaatrivdv sigdshclal shdnevyawg nnsmgqcgqg nstgpitkpk kvsgldgiai
      721 qqisagtshs lawtalprdr qvvawhrpyc vdleestfsh lrsflerycd kinseipplp
      781 fpssrehhsf lklclkllsn hlalalaggv atsilgrqag plrnllfrlm dstvpdeiqe
      841 vvietlsvga tmllpplrer mellhsllpq gpdrweslsk gqrmqldiil tslqdhthva
      901 sllgysspsd aadlssvctg ygnlsdqpyg tqschpdthl aeilmktllr nlgfytdqaf
      961 geleknsdkf llgtsssens qpahlhellc slqkqllafc hinnisenss svallhkhlq
     1021 lllphatdiy srsanllkes pwngsvgekl rdviyvsaag smlcqivnsl lllpvsvarp
     1081 llsylldllp pldclnrllp aadlledqel qwplhggpel idpaglplpq paqswvwlvd
     1141 lertiallig rclggmlqgs pvspeeqdta ywmktplfsd gvemdtpqld kcmsclleva
     1201 lsgneeqkpf dyklrpeiav yvdlalgcsk eparslwism qdyavskdwd satlsnesll
     1261 dtvsrfvlaa llkhtnllsq acgesryqpg khlsevyrcv ykvrsrllac knleliqtrs
     1321 ssrdrwisen qdsadvdpqe hsftrtidee aemeeqaerd reeghpeped eeeerehevm
     1381 tagkifqcfl sarevarsrd rdrmnsgags garaddpppq sqqerrvstd lpegqdvyta
     1441 acnsvihrca llilgvspvi delqkrreeg qlqqpstsas eggglmtrse sltaesrlvh
     1501 tspnyrliks rsesdlsqpe sdeegyalsg rrnvdldlaa shrkrgpmhs qleslsdswa
     1561 rlkhsrdwlc nssysfesdf dltkslgvht lienvvsfvs gdvgnapgfk epeesmstsp
     1621 qasiiameqq qlraelrlea lhqilvllsg meekgsisla gsrlssgfqs stlltsvrlq
     1681 flagcfglgt vghtggkges grlhhyqdgi raakrniqie iqvavhkiyq qlsatleral
     1741 qankhhieaq qrlllvtvfa lsvhyqpvdv slaistglln vlsqlcgtdt mlgqplqllp
     1801 ktgvsqlsta lkvastrllq ilaittgtya dklspkvvqs lldllcsqlk nllsqtgvlh
     1861 masfgegeqe dgeeeekkvd ssgetekkdf raalrkqhaa elhlgdflvf lrrvvsskai
     1921 qskmaspkwt evllniasqk cssgiplvgn lrtrllalhv leavlpaces gveddqmaqi
     1981 verlfsllsd cmwetpiaqa khaiqikeke qeiklqqgel eeedenlpiq evsfdpekaq
     2041 cclvengqil thgsggkgyg lastgvtsgc yqwkfyivke nrgnegtcvg vsrwpvhdfn
     2101 hrttsdmwly raysgnlyhn geqtltlssf tqgdfitcvl dmeartisfg kngeepklaf
     2161 edvdaaelyp cvmfyssnpg ekvkicdmqm rgtprdllpg dpicspvaav laeatiqlir
     2221 ilhrtdrwty cinkkmmerl hkikicikes gqklkksrsv qsreenemre ekeskeeekg
     2281 khtrhgladl selqlrtlci evwpvlavig gvdaglrvgg rcvhkqtgrh atllgvvkeg
     2341 stsakvqwde aeitisdtpl ynlepceplp fdvarfrglt asvlldltyl tgvhedmgkq
     2401 stkrhekkhr heseekgdve qkpesesald mrtgltsddv ksqsttssks eneiasfsld
     2461 ptlpsvesqh qitegkrknh ehmsknhdva qseiravqls ylylgamksl sallgcskya
     2521 elllipkvla enghnsdcas spvvhedvem raalqflmrh mvkravmrsp ikralgladl
     2581 eraqamiykl vvhglledqf ggkikqeidq qaeesdpaqq aqtpvttsps assttsfmss
     2641 sledtttatt pvtdtetvpa sespgvmpls llrqmfssyp tttvlptrra qtppisslpt
     2701 spsdevgrrq sltspdsqsa rpanrtalsd pssrlstspp ppaiavplle mgfslrqiak
     2761 ameatgarge adaqnitvla mwmiehpghe deeepqsgst adsrpgaavl gsggksndpc
     2821 ylqspgdips adaaemeegf sespdnldht enaasgsgps argrsavtrr hkfdlaartl
     2881 laraaglyrs vqahrnqsrr egislqqdpg alydfnldee leidlddeam eamfgqdlts
     2941 dndilgmwip evldwptwhv cesedreevv vcelcecsvv sfnqhmkrnh pgcgrsanrq
     3001 gyrsngsyvd gwfggecgsg npyyllcgtc rekylamktk skstsseryk gqapdligkq
     3061 dsvyeedwdm ldvdedeklt geeefellag plglndrriv pepvqfpdsd plgasvamvt
     3121 atnsmeetlm qielcfsgch gsveksssgr itlgeqaaal anphdrvval rrvtaaaqvl
     3181 lartmvmral sllsvsgssc slaagleslg ltdirtlvrl mclaaagrag lstspsamas
     3241 tsersrgghs kankpiscla ylstavgcla snapsaakll vqlctqnlis aatgvnlttv
     3301 ddsiqrkflp sflrgiaeen klvtspnfvv tqalvallad kgaklrpnyd ksevekkgli
     3361 aqlyahpsyd psavgplela nalaacclss rlssqhrqwa aqqlvrtlaa hdrdnqttlq
     3421 tladmggdlr kcsfikleah qnrvmtcvwc nkkgllatsg ndgtirvwnv tkkqyslqqt
     3481 cvfnrlegda eeslgspsdp sfspvswsis gkylagalek mvniwqvngg kglvdiqphw
     3541 vsalawpeeg patawsgesp elllvgrmdg slglievvdv stmhrreleh cyrkdvsvtc
     3601 iawfsedrpf avgyfdgkll lgtkeplekg givlidahkd tlismkwdpt ghilmtcake
     3661 dsvklwgsis gcwcclhslc hpsivngiaw crlpgkgskl qllmatgcqs glvcvwripq
     3721 dttqtnvtsa egwweqesnc qdgyrkssga kcvyqlrghi tpvrtvafss dglalvsggl
     3781 gglmniwslr dgsvlqtvvi gsgaiqttvw ipevgvaacs nrskdvlvvn ctaewaaanh
     3841 vlatcrtalk qqgvlglnma pcmraflerl pmmlqeqyay ekphvvcgdq lvhspymqcl
     3901 aslavglhld qllcnppvpp hhqnclpdpa swnpnewawl ecfsttikaa ealtngaqfp
     3961 esftvpdlep vpedelvflm dnskwingmd eqimswatsr pedwhlggkc dvylwgagrh
     4021 gqlaeagrnv mvpaaapsfs qaqqvicgqn ctfviqangt vlacgegsyg rlgqgnsddl
     4081 hvltvisalq gfvvtqlvts cgsdghsmal tesgevfswg dgdygklghg nsdrqrrprq
     4141 iealqgeevv qmscgfkhsa vvtsdgklft fgngdygrlg lgntsnkklp ervtalegyq
     4201 igqvacglnh tlavsadgsm vwafgdgdyg klglgnstak sspqkidvlc gigikkvacg
     4261 tqfsvaltkd ghvytfgqdr liglpegrar nhnrpqqipv lagviiedva vgaehtlala
     4321 sngdvyawgs nsegqlglgh tnhvreptlv tglqgknvrq isagrchsaa wtappvppra
     4381 pgvsvplqlg lpdtvppqyg alrevsihtv rarlrllyhf sdlmysswrl lnlspnnqns
     4441 tshynagtwg ivqgqlrpll aprvytlpmv rsigktmvqg knygpqitvk ristrgrkck
     4501 pifvqiarqv vklnasdlrl psrawkvklv gegaddaggv fddtitemcq eletgivdll
     4561 ipspnataev gynrdrflfn psacldehlm qfkflgilmg vairtkkpld lhlaplvwkq
     4621 lccvpltled leevdllyvq tlnsilhied sgiteesfhe mipldsfvgq sadgkmvpii
     4681 pggnsipltf snrkeyvera ieyrlhemdr qvaavregms wivpvpllsl ltakqleqmv
     4741 cgmpeisvev lkkvvryrev deqhqlvqwf whtleefsne ervlfmrfvs grsrlpanta
     4801 disqrfqimk vdrpydslpt sqtcffqlrl ppyssqlvma erlryainnc rsidmdnyml
     4861 srnvdnaegs dtdy
//
LOCUS       XP_047289203            4874 aa            linear   PRI 05-AUG-2025
DEFINITION  putative E3 ubiquitin-protein ligase HERC1 isoform X24 [Homo
            sapiens].
ACCESSION   XP_047289203
VERSION     XP_047289203.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433247.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4874
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4874
                     /product="putative E3 ubiquitin-protein ligase HERC1
                     isoform X24"
                     /calculated_mol_wt=533385
     Region          374..703
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          683..733
                     /region_name="RCC1"
                     /note="Regulator of chromosome condensation (RCC1) repeat;
                     pfam00415"
                     /db_xref="CDD:395335"
     Region          2031..2188
                     /region_name="SPRY_HERC1"
                     /note="SPRY domain in HERC1; cd12881"
                     /db_xref="CDD:293939"
     Region          2744..2787
                     /region_name="UBA_HERC1"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC1 and similar proteins; cd14401"
                     /db_xref="CDD:270584"
     Region          <3400..3791
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          3445..3488
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3502..3537
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3542..3589
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3598..3633
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3642..3678
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3685..3716
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3763..3799
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          4012..4348
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          4486..4854
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4491,4532,4543,4610,4788,4818..4819,4822..4826,4846,
                     4853)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4638,4641..4642,4644..4645,4648,4656,4658,
                     4662..4663,4665,4674,4679,4696,4700)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4874
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /coded_by="XM_047433247.1:149..14773"
                     /db_xref="GeneID:8925"
                     /db_xref="HGNC:HGNC:4867"
                     /db_xref="MIM:605109"
ORIGIN      
        1 matmippvkl kwlehlnssw itedsesiat regvavlysk lvsnkevvpl pqqvlclkgp
       61 qlpdferesl ssdeqdhyld allssqlala kmvcsdspfa galrkrllvl qrvfyalsnk
      121 yhdkgkvkqq qhspesssgs advhsvserp rsstdaliem gvrtglsllf allrqswmmp
      181 vsgpglslcn dvihtaievv sslpplslan eskippmgld clsqvttflk gvtipnsgad
      241 tlgrrlasel llglaaqrgs lryllewiem algasavvht mekgkllssq egmisfdcfm
      301 tilmqmrrsl gssadrsqwr eptrtsdglc slyeaalclf eevcrmasdy srtcaspdsi
      361 qtgdapivse tcevyvwgsn sshqlvegtq ekilqpklap sfsdaqtiea gqyctfvist
      421 dgsvracgkg sygrlglgds nnqstlkklt fephrsikkv ssskgsdght lafttegevf
      481 swgdgdygkl ghgnsstqky pkliqgplqg kvvvcvsagy rhsaavtedg elytwgegdf
      541 grlghgdsns rniptlvkdi snvgevscgs shtialskdg rtvwsfgggd ngklghgdtn
      601 rvykpkviea lqgmfirkvc agsqsslalt stgqvyawgc gaclgcgsse atalrpklie
      661 elaatrivdv sigdshclal shdnevyawg nnsmgqcgqg nstgpitkpk kvsgldgiai
      721 qqisagtshs lawtalprdr qvvawhrpyc vdleestfsh lrsflerycd kinseipplp
      781 fpssrehhsf lklclkllsn hlalalaggv atsilgrqag plrnllfrlm dstvpdeiqe
      841 vvietlsvga tmllpplrer mellhsllpq gpdrweslsk gqrmqldiil tslqdhthva
      901 sllgysspsd aadlssvctg ygnlsdqpyg tqschpdthl aeilmktllr nlgfytdqaf
      961 geleknsdkf llgtsssens qpahlhellc slqkqllafc hinnisenss svallhkhlq
     1021 lllphatdiy srsanllkes pwngsvgekl rdviyvsaag smlcqivnsl lllpvsvarp
     1081 llsylldllp pldclnrllp aadlledqel qwplhggpel idpaglplpq paqswvwlvd
     1141 lertiallig rclggmlqgs pvspeeqdta ywmktplfsd gvemdtpqld kcmsclleva
     1201 lsgneeqkpf dyklrpeiav yvdlalgcsk eparslwism qdyavskdwd satlsnesll
     1261 dtvsrfvlaa llkhtnllsq acgesryqpg khlsevyrcv ykvrsrllac knleliqtrs
     1321 ssrdrwisen qdsadvdpqe hsftrtidee aemeeqaerd reeghpeped eeeerehevm
     1381 tagkifqcfl sarevarsrd rdrmnsgags garaddpppq sqqerrvstd lpegqdvyta
     1441 acnsvihrca llilgvspvi delqkrreeg qlqqpstsas eggglmtrse sltaesrlvh
     1501 tspnyrliks rsesdlsqpe sdeegyalsg rrnvdldlaa shrkrgpmhs qleslsdswa
     1561 rlkhsrdwlc nssysfesdf dltkslgvht lienvvsfvs gdvgnapgfk epeesmstsp
     1621 qasiiameqq qlraelrlea lhqilvllsg meekgsisla gsrlssgfqs stlltsvrlq
     1681 flagcfglgt vghtggkges grlhhyqdgi raakrniqie iqvavhkiyq qlsatleral
     1741 qankhhieaq qrlllvtvfa lsvhyqpvdv slaistglln vlsqlcgtdt mlgqplqllp
     1801 ktgvsqlsta lkvastrllq ilaittgtya dklspkvvqs lldllcsqlk nllsqtgvlh
     1861 masfgegeqe dgeeeekkvd ssgetekkdf raalrkqhaa elhlgdflvf lrrvvsskai
     1921 qskmaspkwt evllniasqk cssgiplvgn lrtrllalhv leavlpaces gveddqmaqi
     1981 verlfsllsd cmwetpiaqa khaiqikeke qeiklqqgel eeedenlpiq evsfdpekaq
     2041 cclvengqil thgsggkgyg lastgvtsgc yqwkfyivke nrgnegtcvg vsrwpvhdfn
     2101 hrttsdmwly raysgnlyhn geqtltlssf tqgdfitcvl dmeartisfg kngeepklaf
     2161 edvdaaelyp cvmfyssnpg ekvkicdmqm rgtprdllpg dpicspvaav laeatiqlir
     2221 ilhrtdrwty cinkkmmerl hkikicikes gqklkksrsv qsreenemre ekeskeeekg
     2281 khtrhgladl selqlrtlci evwpvlavig gvdaglrvgg rcvhkqtgrh atllgvvkeg
     2341 stsakvqwde aeitisdtpl ynlepceplp fdvarfrglt asvlldltyl tgvhedmgkq
     2401 stkrhekkhr heseekgdve qkpesesald mrtgltsddv ksqsttssks eneiasfsld
     2461 ptlpsvesqh qitegkrknh ehmsknhdva qseiravqls ylylgamksl sallgcskya
     2521 elllipkvla enghnsdcas spvvhedvem raalqflmrh mvkravmrsp ikralgladl
     2581 eraqamiykl vvhglledqf ggkikqeidq qaeesdpaqq aqtpvttsps assttsfmss
     2641 sledtttatt pvtdtetvpa sespgvmpls llrqmfssyp tttvlptrra qtppisslpt
     2701 spsdevgrrq sltspdsqsa rpanrtalsd pssrlstspp ppaiavplle mgfslrqiak
     2761 ameatgarge adaqnitvla mwmiehpghe deeepqsgst adsrpgaavl gsggksndpc
     2821 ylqspgdips adaaemeegf sespdnldht enaasgsgps argrsavtrr hkfdlaartl
     2881 laraaglyrs vqahrnqsrr egislqqdpg alydfnldee leidlddeam eamfgqdlts
     2941 dndilgmwip evldwptwhv cesedreevv vcelcecsvv sfnqhmkrnh pgcgrsanrq
     3001 gyrsngsyvd gwfggecgsg npyyllcgtc rekylamktk skstsseryk gqapdligkq
     3061 dsvyeedwdm ldvdedeklt geeefellag plglndrriv pepvqfpdsd plgasvamvt
     3121 atnsmeetlm qielcfsgch gsveksssgr itlgeqaaal anphdrvval rrvtaaaqvl
     3181 lartmvmral sllsvsgssc slaagleslg ltdirtlvrl mclaaagrag lstspsamas
     3241 tsersrgghs kankpiscla ylstavgcla snapsaakll vqlctqnlis aatgvnlttv
     3301 ddsiqrkflp sflrgiaeen klvtspnfvv tqalvallad kgaklrpnyd ksevekkgli
     3361 aqlyahpsyd psavgplela nalaacclss rlssqhrqwa aqqlvrtlaa hdrdnqttlq
     3421 tladmggdlr kcsfikleah qnrvmtcvwc nkkgllatsg ndgtirvwnv tkkqyslqqt
     3481 cvfnrlegda eeslgspsdp sfspvswsis gkylagalek mvniwqvngg kglvdiqphw
     3541 vsalawpeeg patawsgesp elllvgrmdg slglievvdv stmhrreleh cyrkdvsvtc
     3601 iawfsedrpf avgyfdgkll lgtkeplekg givlidahkd tlismkwdpt ghilmtcake
     3661 dsvklwgsis gcwcclhslc hpsivngiaw crlpgkgskl qllmatgcqs glvcvwripq
     3721 dttqtnvtsa egwweqesnc qdgyrkssga kcvyqlrghi tpvrtvafss dglalvsggl
     3781 gglmniwslr dgsvlqtvvi gsgaiqttvw ipevgvaacs nrskdvlvvn ctaewaaanh
     3841 vlatcrtalk qqgvlglnma pcmraflerl pmmlqeqyay ekphvvcgdq lvhspymqcl
     3901 aslavglhld qllcnppvpp hhqnclpdpa swnpnewawl ecfsttikaa ealtngaqfp
     3961 esftvpdlep vpedelvflm dnskwingmd eqimswatsr pedwhlggkc dvylwgagrh
     4021 gqlaeagrnv mvpaaapsfs qaqqvicgqn ctfviqangt vlacgegsyg rlgqgnsddl
     4081 hvltvisalq gfvvtqlvts cgsdghsmal tesgevfswg dgdygklghg nsdrqrrprq
     4141 iealqgeevv qmscgfkhsa vvtsdgklft fgngdygrlg lgntsnkklp ervtalegyq
     4201 igqvacglnh tlavsadgsm vwafgdgdyg klglgnstak sspqkidvlc gigikkvacg
     4261 tqfsvaltkd ghvytfgqdr liglpegrar nhnrpqqipv lagviiedva vgaehtlala
     4321 sngdvyawgs nsegqlglgh tnhvreptlv tglqgknvrq isagrchsaa wtappvppra
     4381 pgvsvplqlg lpdtvppqyg alrevsihtv rarlrllyhf sdlmysswrl lnlspnnqns
     4441 tshynagtwg ivqgqlrpll aprvytlpmv rsigktmvqg knygpqitvk ristrgrkck
     4501 pifvqiarqv vklnasdlrl psrawkvklv gegaddaggv fddtitemcq eletgivdll
     4561 ipspnataev gynrdrflfn psacldehlm qfkflgilmg vairtkkpld lhlaplvwkq
     4621 lccvpltled leevdllyvq tlnsilhied sgiteesfhe mipldsfvgq sadgkmvpii
     4681 pggnsipltf snrkeyvera ieyrlhemdr qvaavregms wivpvpllsl ltakqleqmv
     4741 cgmpeisvev lkkvvryrev deqhqlvqwf whtleefsne ervlfmrfvs grsrlpanta
     4801 disqrfqimk vdrpydslpt sqtcffqlrl ppyssqlvma erlryainnc rsidmdnyml
     4861 srnvdnaegs dtdy
//
LOCUS       XP_047289204            4874 aa            linear   PRI 05-AUG-2025
DEFINITION  putative E3 ubiquitin-protein ligase HERC1 isoform X24 [Homo
            sapiens].
ACCESSION   XP_047289204
VERSION     XP_047289204.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433248.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4874
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4874
                     /product="putative E3 ubiquitin-protein ligase HERC1
                     isoform X24"
                     /calculated_mol_wt=533385
     Region          374..703
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          683..733
                     /region_name="RCC1"
                     /note="Regulator of chromosome condensation (RCC1) repeat;
                     pfam00415"
                     /db_xref="CDD:395335"
     Region          2031..2188
                     /region_name="SPRY_HERC1"
                     /note="SPRY domain in HERC1; cd12881"
                     /db_xref="CDD:293939"
     Region          2744..2787
                     /region_name="UBA_HERC1"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC1 and similar proteins; cd14401"
                     /db_xref="CDD:270584"
     Region          <3400..3791
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          3445..3488
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3502..3537
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3542..3589
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3598..3633
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3642..3678
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3685..3716
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3763..3799
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          4012..4348
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          4486..4854
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4491,4532,4543,4610,4788,4818..4819,4822..4826,4846,
                     4853)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4638,4641..4642,4644..4645,4648,4656,4658,
                     4662..4663,4665,4674,4679,4696,4700)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4874
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /coded_by="XM_047433248.1:474..15098"
                     /db_xref="GeneID:8925"
                     /db_xref="HGNC:HGNC:4867"
                     /db_xref="MIM:605109"
ORIGIN      
        1 matmippvkl kwlehlnssw itedsesiat regvavlysk lvsnkevvpl pqqvlclkgp
       61 qlpdferesl ssdeqdhyld allssqlala kmvcsdspfa galrkrllvl qrvfyalsnk
      121 yhdkgkvkqq qhspesssgs advhsvserp rsstdaliem gvrtglsllf allrqswmmp
      181 vsgpglslcn dvihtaievv sslpplslan eskippmgld clsqvttflk gvtipnsgad
      241 tlgrrlasel llglaaqrgs lryllewiem algasavvht mekgkllssq egmisfdcfm
      301 tilmqmrrsl gssadrsqwr eptrtsdglc slyeaalclf eevcrmasdy srtcaspdsi
      361 qtgdapivse tcevyvwgsn sshqlvegtq ekilqpklap sfsdaqtiea gqyctfvist
      421 dgsvracgkg sygrlglgds nnqstlkklt fephrsikkv ssskgsdght lafttegevf
      481 swgdgdygkl ghgnsstqky pkliqgplqg kvvvcvsagy rhsaavtedg elytwgegdf
      541 grlghgdsns rniptlvkdi snvgevscgs shtialskdg rtvwsfgggd ngklghgdtn
      601 rvykpkviea lqgmfirkvc agsqsslalt stgqvyawgc gaclgcgsse atalrpklie
      661 elaatrivdv sigdshclal shdnevyawg nnsmgqcgqg nstgpitkpk kvsgldgiai
      721 qqisagtshs lawtalprdr qvvawhrpyc vdleestfsh lrsflerycd kinseipplp
      781 fpssrehhsf lklclkllsn hlalalaggv atsilgrqag plrnllfrlm dstvpdeiqe
      841 vvietlsvga tmllpplrer mellhsllpq gpdrweslsk gqrmqldiil tslqdhthva
      901 sllgysspsd aadlssvctg ygnlsdqpyg tqschpdthl aeilmktllr nlgfytdqaf
      961 geleknsdkf llgtsssens qpahlhellc slqkqllafc hinnisenss svallhkhlq
     1021 lllphatdiy srsanllkes pwngsvgekl rdviyvsaag smlcqivnsl lllpvsvarp
     1081 llsylldllp pldclnrllp aadlledqel qwplhggpel idpaglplpq paqswvwlvd
     1141 lertiallig rclggmlqgs pvspeeqdta ywmktplfsd gvemdtpqld kcmsclleva
     1201 lsgneeqkpf dyklrpeiav yvdlalgcsk eparslwism qdyavskdwd satlsnesll
     1261 dtvsrfvlaa llkhtnllsq acgesryqpg khlsevyrcv ykvrsrllac knleliqtrs
     1321 ssrdrwisen qdsadvdpqe hsftrtidee aemeeqaerd reeghpeped eeeerehevm
     1381 tagkifqcfl sarevarsrd rdrmnsgags garaddpppq sqqerrvstd lpegqdvyta
     1441 acnsvihrca llilgvspvi delqkrreeg qlqqpstsas eggglmtrse sltaesrlvh
     1501 tspnyrliks rsesdlsqpe sdeegyalsg rrnvdldlaa shrkrgpmhs qleslsdswa
     1561 rlkhsrdwlc nssysfesdf dltkslgvht lienvvsfvs gdvgnapgfk epeesmstsp
     1621 qasiiameqq qlraelrlea lhqilvllsg meekgsisla gsrlssgfqs stlltsvrlq
     1681 flagcfglgt vghtggkges grlhhyqdgi raakrniqie iqvavhkiyq qlsatleral
     1741 qankhhieaq qrlllvtvfa lsvhyqpvdv slaistglln vlsqlcgtdt mlgqplqllp
     1801 ktgvsqlsta lkvastrllq ilaittgtya dklspkvvqs lldllcsqlk nllsqtgvlh
     1861 masfgegeqe dgeeeekkvd ssgetekkdf raalrkqhaa elhlgdflvf lrrvvsskai
     1921 qskmaspkwt evllniasqk cssgiplvgn lrtrllalhv leavlpaces gveddqmaqi
     1981 verlfsllsd cmwetpiaqa khaiqikeke qeiklqqgel eeedenlpiq evsfdpekaq
     2041 cclvengqil thgsggkgyg lastgvtsgc yqwkfyivke nrgnegtcvg vsrwpvhdfn
     2101 hrttsdmwly raysgnlyhn geqtltlssf tqgdfitcvl dmeartisfg kngeepklaf
     2161 edvdaaelyp cvmfyssnpg ekvkicdmqm rgtprdllpg dpicspvaav laeatiqlir
     2221 ilhrtdrwty cinkkmmerl hkikicikes gqklkksrsv qsreenemre ekeskeeekg
     2281 khtrhgladl selqlrtlci evwpvlavig gvdaglrvgg rcvhkqtgrh atllgvvkeg
     2341 stsakvqwde aeitisdtpl ynlepceplp fdvarfrglt asvlldltyl tgvhedmgkq
     2401 stkrhekkhr heseekgdve qkpesesald mrtgltsddv ksqsttssks eneiasfsld
     2461 ptlpsvesqh qitegkrknh ehmsknhdva qseiravqls ylylgamksl sallgcskya
     2521 elllipkvla enghnsdcas spvvhedvem raalqflmrh mvkravmrsp ikralgladl
     2581 eraqamiykl vvhglledqf ggkikqeidq qaeesdpaqq aqtpvttsps assttsfmss
     2641 sledtttatt pvtdtetvpa sespgvmpls llrqmfssyp tttvlptrra qtppisslpt
     2701 spsdevgrrq sltspdsqsa rpanrtalsd pssrlstspp ppaiavplle mgfslrqiak
     2761 ameatgarge adaqnitvla mwmiehpghe deeepqsgst adsrpgaavl gsggksndpc
     2821 ylqspgdips adaaemeegf sespdnldht enaasgsgps argrsavtrr hkfdlaartl
     2881 laraaglyrs vqahrnqsrr egislqqdpg alydfnldee leidlddeam eamfgqdlts
     2941 dndilgmwip evldwptwhv cesedreevv vcelcecsvv sfnqhmkrnh pgcgrsanrq
     3001 gyrsngsyvd gwfggecgsg npyyllcgtc rekylamktk skstsseryk gqapdligkq
     3061 dsvyeedwdm ldvdedeklt geeefellag plglndrriv pepvqfpdsd plgasvamvt
     3121 atnsmeetlm qielcfsgch gsveksssgr itlgeqaaal anphdrvval rrvtaaaqvl
     3181 lartmvmral sllsvsgssc slaagleslg ltdirtlvrl mclaaagrag lstspsamas
     3241 tsersrgghs kankpiscla ylstavgcla snapsaakll vqlctqnlis aatgvnlttv
     3301 ddsiqrkflp sflrgiaeen klvtspnfvv tqalvallad kgaklrpnyd ksevekkgli
     3361 aqlyahpsyd psavgplela nalaacclss rlssqhrqwa aqqlvrtlaa hdrdnqttlq
     3421 tladmggdlr kcsfikleah qnrvmtcvwc nkkgllatsg ndgtirvwnv tkkqyslqqt
     3481 cvfnrlegda eeslgspsdp sfspvswsis gkylagalek mvniwqvngg kglvdiqphw
     3541 vsalawpeeg patawsgesp elllvgrmdg slglievvdv stmhrreleh cyrkdvsvtc
     3601 iawfsedrpf avgyfdgkll lgtkeplekg givlidahkd tlismkwdpt ghilmtcake
     3661 dsvklwgsis gcwcclhslc hpsivngiaw crlpgkgskl qllmatgcqs glvcvwripq
     3721 dttqtnvtsa egwweqesnc qdgyrkssga kcvyqlrghi tpvrtvafss dglalvsggl
     3781 gglmniwslr dgsvlqtvvi gsgaiqttvw ipevgvaacs nrskdvlvvn ctaewaaanh
     3841 vlatcrtalk qqgvlglnma pcmraflerl pmmlqeqyay ekphvvcgdq lvhspymqcl
     3901 aslavglhld qllcnppvpp hhqnclpdpa swnpnewawl ecfsttikaa ealtngaqfp
     3961 esftvpdlep vpedelvflm dnskwingmd eqimswatsr pedwhlggkc dvylwgagrh
     4021 gqlaeagrnv mvpaaapsfs qaqqvicgqn ctfviqangt vlacgegsyg rlgqgnsddl
     4081 hvltvisalq gfvvtqlvts cgsdghsmal tesgevfswg dgdygklghg nsdrqrrprq
     4141 iealqgeevv qmscgfkhsa vvtsdgklft fgngdygrlg lgntsnkklp ervtalegyq
     4201 igqvacglnh tlavsadgsm vwafgdgdyg klglgnstak sspqkidvlc gigikkvacg
     4261 tqfsvaltkd ghvytfgqdr liglpegrar nhnrpqqipv lagviiedva vgaehtlala
     4321 sngdvyawgs nsegqlglgh tnhvreptlv tglqgknvrq isagrchsaa wtappvppra
     4381 pgvsvplqlg lpdtvppqyg alrevsihtv rarlrllyhf sdlmysswrl lnlspnnqns
     4441 tshynagtwg ivqgqlrpll aprvytlpmv rsigktmvqg knygpqitvk ristrgrkck
     4501 pifvqiarqv vklnasdlrl psrawkvklv gegaddaggv fddtitemcq eletgivdll
     4561 ipspnataev gynrdrflfn psacldehlm qfkflgilmg vairtkkpld lhlaplvwkq
     4621 lccvpltled leevdllyvq tlnsilhied sgiteesfhe mipldsfvgq sadgkmvpii
     4681 pggnsipltf snrkeyvera ieyrlhemdr qvaavregms wivpvpllsl ltakqleqmv
     4741 cgmpeisvev lkkvvryrev deqhqlvqwf whtleefsne ervlfmrfvs grsrlpanta
     4801 disqrfqimk vdrpydslpt sqtcffqlrl ppyssqlvma erlryainnc rsidmdnyml
     4861 srnvdnaegs dtdy
//
LOCUS       XP_047289205            4874 aa            linear   PRI 05-AUG-2025
DEFINITION  putative E3 ubiquitin-protein ligase HERC1 isoform X24 [Homo
            sapiens].
ACCESSION   XP_047289205
VERSION     XP_047289205.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433249.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4874
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4874
                     /product="putative E3 ubiquitin-protein ligase HERC1
                     isoform X24"
                     /calculated_mol_wt=533385
     Region          374..703
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          683..733
                     /region_name="RCC1"
                     /note="Regulator of chromosome condensation (RCC1) repeat;
                     pfam00415"
                     /db_xref="CDD:395335"
     Region          2031..2188
                     /region_name="SPRY_HERC1"
                     /note="SPRY domain in HERC1; cd12881"
                     /db_xref="CDD:293939"
     Region          2744..2787
                     /region_name="UBA_HERC1"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC1 and similar proteins; cd14401"
                     /db_xref="CDD:270584"
     Region          <3400..3791
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          3445..3488
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3502..3537
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3542..3589
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3598..3633
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3642..3678
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3685..3716
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3763..3799
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          4012..4348
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          4486..4854
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4491,4532,4543,4610,4788,4818..4819,4822..4826,4846,
                     4853)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4638,4641..4642,4644..4645,4648,4656,4658,
                     4662..4663,4665,4674,4679,4696,4700)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4874
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /coded_by="XM_047433249.1:3471..18095"
                     /db_xref="GeneID:8925"
                     /db_xref="HGNC:HGNC:4867"
                     /db_xref="MIM:605109"
ORIGIN      
        1 matmippvkl kwlehlnssw itedsesiat regvavlysk lvsnkevvpl pqqvlclkgp
       61 qlpdferesl ssdeqdhyld allssqlala kmvcsdspfa galrkrllvl qrvfyalsnk
      121 yhdkgkvkqq qhspesssgs advhsvserp rsstdaliem gvrtglsllf allrqswmmp
      181 vsgpglslcn dvihtaievv sslpplslan eskippmgld clsqvttflk gvtipnsgad
      241 tlgrrlasel llglaaqrgs lryllewiem algasavvht mekgkllssq egmisfdcfm
      301 tilmqmrrsl gssadrsqwr eptrtsdglc slyeaalclf eevcrmasdy srtcaspdsi
      361 qtgdapivse tcevyvwgsn sshqlvegtq ekilqpklap sfsdaqtiea gqyctfvist
      421 dgsvracgkg sygrlglgds nnqstlkklt fephrsikkv ssskgsdght lafttegevf
      481 swgdgdygkl ghgnsstqky pkliqgplqg kvvvcvsagy rhsaavtedg elytwgegdf
      541 grlghgdsns rniptlvkdi snvgevscgs shtialskdg rtvwsfgggd ngklghgdtn
      601 rvykpkviea lqgmfirkvc agsqsslalt stgqvyawgc gaclgcgsse atalrpklie
      661 elaatrivdv sigdshclal shdnevyawg nnsmgqcgqg nstgpitkpk kvsgldgiai
      721 qqisagtshs lawtalprdr qvvawhrpyc vdleestfsh lrsflerycd kinseipplp
      781 fpssrehhsf lklclkllsn hlalalaggv atsilgrqag plrnllfrlm dstvpdeiqe
      841 vvietlsvga tmllpplrer mellhsllpq gpdrweslsk gqrmqldiil tslqdhthva
      901 sllgysspsd aadlssvctg ygnlsdqpyg tqschpdthl aeilmktllr nlgfytdqaf
      961 geleknsdkf llgtsssens qpahlhellc slqkqllafc hinnisenss svallhkhlq
     1021 lllphatdiy srsanllkes pwngsvgekl rdviyvsaag smlcqivnsl lllpvsvarp
     1081 llsylldllp pldclnrllp aadlledqel qwplhggpel idpaglplpq paqswvwlvd
     1141 lertiallig rclggmlqgs pvspeeqdta ywmktplfsd gvemdtpqld kcmsclleva
     1201 lsgneeqkpf dyklrpeiav yvdlalgcsk eparslwism qdyavskdwd satlsnesll
     1261 dtvsrfvlaa llkhtnllsq acgesryqpg khlsevyrcv ykvrsrllac knleliqtrs
     1321 ssrdrwisen qdsadvdpqe hsftrtidee aemeeqaerd reeghpeped eeeerehevm
     1381 tagkifqcfl sarevarsrd rdrmnsgags garaddpppq sqqerrvstd lpegqdvyta
     1441 acnsvihrca llilgvspvi delqkrreeg qlqqpstsas eggglmtrse sltaesrlvh
     1501 tspnyrliks rsesdlsqpe sdeegyalsg rrnvdldlaa shrkrgpmhs qleslsdswa
     1561 rlkhsrdwlc nssysfesdf dltkslgvht lienvvsfvs gdvgnapgfk epeesmstsp
     1621 qasiiameqq qlraelrlea lhqilvllsg meekgsisla gsrlssgfqs stlltsvrlq
     1681 flagcfglgt vghtggkges grlhhyqdgi raakrniqie iqvavhkiyq qlsatleral
     1741 qankhhieaq qrlllvtvfa lsvhyqpvdv slaistglln vlsqlcgtdt mlgqplqllp
     1801 ktgvsqlsta lkvastrllq ilaittgtya dklspkvvqs lldllcsqlk nllsqtgvlh
     1861 masfgegeqe dgeeeekkvd ssgetekkdf raalrkqhaa elhlgdflvf lrrvvsskai
     1921 qskmaspkwt evllniasqk cssgiplvgn lrtrllalhv leavlpaces gveddqmaqi
     1981 verlfsllsd cmwetpiaqa khaiqikeke qeiklqqgel eeedenlpiq evsfdpekaq
     2041 cclvengqil thgsggkgyg lastgvtsgc yqwkfyivke nrgnegtcvg vsrwpvhdfn
     2101 hrttsdmwly raysgnlyhn geqtltlssf tqgdfitcvl dmeartisfg kngeepklaf
     2161 edvdaaelyp cvmfyssnpg ekvkicdmqm rgtprdllpg dpicspvaav laeatiqlir
     2221 ilhrtdrwty cinkkmmerl hkikicikes gqklkksrsv qsreenemre ekeskeeekg
     2281 khtrhgladl selqlrtlci evwpvlavig gvdaglrvgg rcvhkqtgrh atllgvvkeg
     2341 stsakvqwde aeitisdtpl ynlepceplp fdvarfrglt asvlldltyl tgvhedmgkq
     2401 stkrhekkhr heseekgdve qkpesesald mrtgltsddv ksqsttssks eneiasfsld
     2461 ptlpsvesqh qitegkrknh ehmsknhdva qseiravqls ylylgamksl sallgcskya
     2521 elllipkvla enghnsdcas spvvhedvem raalqflmrh mvkravmrsp ikralgladl
     2581 eraqamiykl vvhglledqf ggkikqeidq qaeesdpaqq aqtpvttsps assttsfmss
     2641 sledtttatt pvtdtetvpa sespgvmpls llrqmfssyp tttvlptrra qtppisslpt
     2701 spsdevgrrq sltspdsqsa rpanrtalsd pssrlstspp ppaiavplle mgfslrqiak
     2761 ameatgarge adaqnitvla mwmiehpghe deeepqsgst adsrpgaavl gsggksndpc
     2821 ylqspgdips adaaemeegf sespdnldht enaasgsgps argrsavtrr hkfdlaartl
     2881 laraaglyrs vqahrnqsrr egislqqdpg alydfnldee leidlddeam eamfgqdlts
     2941 dndilgmwip evldwptwhv cesedreevv vcelcecsvv sfnqhmkrnh pgcgrsanrq
     3001 gyrsngsyvd gwfggecgsg npyyllcgtc rekylamktk skstsseryk gqapdligkq
     3061 dsvyeedwdm ldvdedeklt geeefellag plglndrriv pepvqfpdsd plgasvamvt
     3121 atnsmeetlm qielcfsgch gsveksssgr itlgeqaaal anphdrvval rrvtaaaqvl
     3181 lartmvmral sllsvsgssc slaagleslg ltdirtlvrl mclaaagrag lstspsamas
     3241 tsersrgghs kankpiscla ylstavgcla snapsaakll vqlctqnlis aatgvnlttv
     3301 ddsiqrkflp sflrgiaeen klvtspnfvv tqalvallad kgaklrpnyd ksevekkgli
     3361 aqlyahpsyd psavgplela nalaacclss rlssqhrqwa aqqlvrtlaa hdrdnqttlq
     3421 tladmggdlr kcsfikleah qnrvmtcvwc nkkgllatsg ndgtirvwnv tkkqyslqqt
     3481 cvfnrlegda eeslgspsdp sfspvswsis gkylagalek mvniwqvngg kglvdiqphw
     3541 vsalawpeeg patawsgesp elllvgrmdg slglievvdv stmhrreleh cyrkdvsvtc
     3601 iawfsedrpf avgyfdgkll lgtkeplekg givlidahkd tlismkwdpt ghilmtcake
     3661 dsvklwgsis gcwcclhslc hpsivngiaw crlpgkgskl qllmatgcqs glvcvwripq
     3721 dttqtnvtsa egwweqesnc qdgyrkssga kcvyqlrghi tpvrtvafss dglalvsggl
     3781 gglmniwslr dgsvlqtvvi gsgaiqttvw ipevgvaacs nrskdvlvvn ctaewaaanh
     3841 vlatcrtalk qqgvlglnma pcmraflerl pmmlqeqyay ekphvvcgdq lvhspymqcl
     3901 aslavglhld qllcnppvpp hhqnclpdpa swnpnewawl ecfsttikaa ealtngaqfp
     3961 esftvpdlep vpedelvflm dnskwingmd eqimswatsr pedwhlggkc dvylwgagrh
     4021 gqlaeagrnv mvpaaapsfs qaqqvicgqn ctfviqangt vlacgegsyg rlgqgnsddl
     4081 hvltvisalq gfvvtqlvts cgsdghsmal tesgevfswg dgdygklghg nsdrqrrprq
     4141 iealqgeevv qmscgfkhsa vvtsdgklft fgngdygrlg lgntsnkklp ervtalegyq
     4201 igqvacglnh tlavsadgsm vwafgdgdyg klglgnstak sspqkidvlc gigikkvacg
     4261 tqfsvaltkd ghvytfgqdr liglpegrar nhnrpqqipv lagviiedva vgaehtlala
     4321 sngdvyawgs nsegqlglgh tnhvreptlv tglqgknvrq isagrchsaa wtappvppra
     4381 pgvsvplqlg lpdtvppqyg alrevsihtv rarlrllyhf sdlmysswrl lnlspnnqns
     4441 tshynagtwg ivqgqlrpll aprvytlpmv rsigktmvqg knygpqitvk ristrgrkck
     4501 pifvqiarqv vklnasdlrl psrawkvklv gegaddaggv fddtitemcq eletgivdll
     4561 ipspnataev gynrdrflfn psacldehlm qfkflgilmg vairtkkpld lhlaplvwkq
     4621 lccvpltled leevdllyvq tlnsilhied sgiteesfhe mipldsfvgq sadgkmvpii
     4681 pggnsipltf snrkeyvera ieyrlhemdr qvaavregms wivpvpllsl ltakqleqmv
     4741 cgmpeisvev lkkvvryrev deqhqlvqwf whtleefsne ervlfmrfvs grsrlpanta
     4801 disqrfqimk vdrpydslpt sqtcffqlrl ppyssqlvma erlryainnc rsidmdnyml
     4861 srnvdnaegs dtdy
//
LOCUS       XP_047289206            4869 aa            linear   PRI 05-AUG-2025
DEFINITION  putative E3 ubiquitin-protein ligase HERC1 isoform X25 [Homo
            sapiens].
ACCESSION   XP_047289206
VERSION     XP_047289206.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433250.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4869
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4869
                     /product="putative E3 ubiquitin-protein ligase HERC1
                     isoform X25"
                     /calculated_mol_wt=532805
     Region          374..703
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          683..733
                     /region_name="RCC1"
                     /note="Regulator of chromosome condensation (RCC1) repeat;
                     pfam00415"
                     /db_xref="CDD:395335"
     Region          2031..2188
                     /region_name="SPRY_HERC1"
                     /note="SPRY domain in HERC1; cd12881"
                     /db_xref="CDD:293939"
     Region          2744..2787
                     /region_name="UBA_HERC1"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC1 and similar proteins; cd14401"
                     /db_xref="CDD:270584"
     Region          <3395..3786
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          3440..3483
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3497..3532
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3537..3584
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3593..3628
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3637..3673
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3680..3711
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3758..3794
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          4007..4343
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          4481..4849
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4486,4527,4538,4605,4783,4813..4814,4817..4821,4841,
                     4848)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4633,4636..4637,4639..4640,4643,4651,4653,
                     4657..4658,4660,4669,4674,4691,4695)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4869
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /coded_by="XM_047433250.1:154..14763"
                     /db_xref="GeneID:8925"
                     /db_xref="HGNC:HGNC:4867"
                     /db_xref="MIM:605109"
ORIGIN      
        1 matmippvkl kwlehlnssw itedsesiat regvavlysk lvsnkevvpl pqqvlclkgp
       61 qlpdferesl ssdeqdhyld allssqlala kmvcsdspfa galrkrllvl qrvfyalsnk
      121 yhdkgkvkqq qhspesssgs advhsvserp rsstdaliem gvrtglsllf allrqswmmp
      181 vsgpglslcn dvihtaievv sslpplslan eskippmgld clsqvttflk gvtipnsgad
      241 tlgrrlasel llglaaqrgs lryllewiem algasavvht mekgkllssq egmisfdcfm
      301 tilmqmrrsl gssadrsqwr eptrtsdglc slyeaalclf eevcrmasdy srtcaspdsi
      361 qtgdapivse tcevyvwgsn sshqlvegtq ekilqpklap sfsdaqtiea gqyctfvist
      421 dgsvracgkg sygrlglgds nnqstlkklt fephrsikkv ssskgsdght lafttegevf
      481 swgdgdygkl ghgnsstqky pkliqgplqg kvvvcvsagy rhsaavtedg elytwgegdf
      541 grlghgdsns rniptlvkdi snvgevscgs shtialskdg rtvwsfgggd ngklghgdtn
      601 rvykpkviea lqgmfirkvc agsqsslalt stgqvyawgc gaclgcgsse atalrpklie
      661 elaatrivdv sigdshclal shdnevyawg nnsmgqcgqg nstgpitkpk kvsgldgiai
      721 qqisagtshs lawtalprdr qvvawhrpyc vdleestfsh lrsflerycd kinseipplp
      781 fpssrehhsf lklclkllsn hlalalaggv atsilgrqag plrnllfrlm dstvpdeiqe
      841 vvietlsvga tmllpplrer mellhsllpq gpdrweslsk gqrmqldiil tslqdhthva
      901 sllgysspsd aadlssvctg ygnlsdqpyg tqschpdthl aeilmktllr nlgfytdqaf
      961 geleknsdkf llgtsssens qpahlhellc slqkqllafc hinnisenss svallhkhlq
     1021 lllphatdiy srsanllkes pwngsvgekl rdviyvsaag smlcqivnsl lllpvsvarp
     1081 llsylldllp pldclnrllp aadlledqel qwplhggpel idpaglplpq paqswvwlvd
     1141 lertiallig rclggmlqgs pvspeeqdta ywmktplfsd gvemdtpqld kcmsclleva
     1201 lsgneeqkpf dyklrpeiav yvdlalgcsk eparslwism qdyavskdwd satlsnesll
     1261 dtvsrfvlaa llkhtnllsq acgesryqpg khlsevyrcv ykvrsrllac knleliqtrs
     1321 ssrdrwisen qdsadvdpqe hsftrtidee aemeeqaerd reeghpeped eeeerehevm
     1381 tagkifqcfl sarevarsrd rdrmnsgags garaddpppq sqqerrvstd lpegqdvyta
     1441 acnsvihrca llilgvspvi delqkrreeg qlqqpstsas eggglmtrse sltaesrlvh
     1501 tspnyrliks rsesdlsqpe sdeegyalsg rrnvdldlaa shrkrgpmhs qleslsdswa
     1561 rlkhsrdwlc nssysfesdf dltkslgvht lienvvsfvs gdvgnapgfk epeesmstsp
     1621 qasiiameqq qlraelrlea lhqilvllsg meekgsisla gsrlssgfqs stlltsvrlq
     1681 flagcfglgt vghtggkges grlhhyqdgi raakrniqie iqvavhkiyq qlsatleral
     1741 qankhhieaq qrlllvtvfa lsvhyqpvdv slaistglln vlsqlcgtdt mlgqplqllp
     1801 ktgvsqlsta lkvastrllq ilaittgtya dklspkvvqs lldllcsqlk nllsqtgvlh
     1861 masfgegeqe dgeeeekkvd ssgetekkdf raalrkqhaa elhlgdflvf lrrvvsskai
     1921 qskmaspkwt evllniasqk cssgiplvgn lrtrllalhv leavlpaces gveddqmaqi
     1981 verlfsllsd cmwetpiaqa khaiqikeke qeiklqqgel eeedenlpiq evsfdpekaq
     2041 cclvengqil thgsggkgyg lastgvtsgc yqwkfyivke nrgnegtcvg vsrwpvhdfn
     2101 hrttsdmwly raysgnlyhn geqtltlssf tqgdfitcvl dmeartisfg kngeepklaf
     2161 edvdaaelyp cvmfyssnpg ekvkicdmqm rgtprdllpg dpicspvaav laeatiqlir
     2221 ilhrtdrwty cinkkmmerl hkikicikes gqklkksrsv qsreenemre ekeskeeekg
     2281 khtrhgladl selqlrtlci evwpvlavig gvdaglrvgg rcvhkqtgrh atllgvvkeg
     2341 stsakvqwde aeitisdtpl ynlepceplp fdvarfrglt asvlldltyl tgvhedmgkq
     2401 stkrhekkhr heseekgdve qkpesesald mrtgltsddv ksqsttssks eneiasfsld
     2461 ptlpsvesqh qitegkrknh ehmsknhdva qseiravqls ylylgamksl sallgcskya
     2521 elllipkvla enghnsdcas spvvhedvem raalqflmrh mvkravmrsp ikralgladl
     2581 eraqamiykl vvhglledqf ggkikqeidq qaeesdpaqq aqtpvttsps assttsfmss
     2641 sledtttatt pvtdtetvpa sespgvmpls llrqmfssyp tttvlptrra qtppisslpt
     2701 spsdevgrrq sltspdsqsa rpanrtalsd pssrlstspp ppaiavplle mgfslrqiak
     2761 ameatgarge adaqnitvla mwmiehpghe deeepqsgst adsrpgaavl gsggksndpc
     2821 ylqspgdips adaaemeegf sespdnldht enaasgsgps argrsavtrr hkfdlaartl
     2881 laraaglyrs vqahrnqsrr egislqqdpg alydfnldee leidlddeam eamfgqdlts
     2941 dndilgmwip evldwptwhv cesedreevv vcelcecsvv sfnqhmkrnh pgcgrsanrq
     3001 gyrsngsyvd gwfggecgsg npyyllcgtc rekylamktk skstsseryk gqapdligkq
     3061 dsvyeedwdm ldvdedeklt geeefellag plglndrriv pepvqfpdsd plgasvamvt
     3121 atnsmeetlm qigchgsvek sssgritlge qaaalanphd rvvalrrvta aaqvllartm
     3181 vmralsllsv sgsscslaag leslgltdir tlvrlmclaa agraglstsp samastsers
     3241 rgghskankp isclaylsta vgclasnaps aakllvqlct qnlisaatgv nlttvddsiq
     3301 rkflpsflrg iaeenklvts pnfvvtqalv alladkgakl rpnydkseve kkgliaqlya
     3361 hpsydpsavg plelanalaa cclssrlssq hrqwaaqqlv rtlaahdrdn qttlqtladm
     3421 ggdlrkcsfi kleahqnrvm tcvwcnkkgl latsgndgti rvwnvtkkqy slqqtcvfnr
     3481 legdaeeslg spsdpsfspv swsisgkyla galekmvniw qvnggkglvd iqphwvsala
     3541 wpeegpataw sgespelllv grmdgslgli evvdvstmhr relehcyrkd vsvtciawfs
     3601 edrpfavgyf dgklllgtke plekggivli dahkdtlism kwdptghilm tcakedsvkl
     3661 wgsisgcwcc lhslchpsiv ngiawcrlpg kgsklqllma tgcqsglvcv wripqdttqt
     3721 nvtsaegwwe qesncqdgyr kssgakcvyq lrghitpvrt vafssdglal vsgglgglmn
     3781 iwslrdgsvl qtvvigsgai qttvwipevg vaacsnrskd vlvvnctaew aaanhvlatc
     3841 rtalkqqgvl glnmapcmra flerlpmmlq eqyayekphv vcgdqlvhsp ymqclaslav
     3901 glhldqllcn ppvpphhqnc lpdpaswnpn ewawlecfst tikaaealtn gaqfpesftv
     3961 pdlepvpede lvflmdnskw ingmdeqims watsrpedwh lggkcdvylw gagrhgqlae
     4021 agrnvmvpaa apsfsqaqqv icgqnctfvi qangtvlacg egsygrlgqg nsddlhvltv
     4081 isalqgfvvt qlvtscgsdg hsmaltesge vfswgdgdyg klghgnsdrq rrprqiealq
     4141 geevvqmscg fkhsavvtsd gklftfgngd ygrlglgnts nkklpervta legyqigqva
     4201 cglnhtlavs adgsmvwafg dgdygklglg nstaksspqk idvlcgigik kvacgtqfsv
     4261 altkdghvyt fgqdrliglp egrarnhnrp qqipvlagvi iedvavgaeh tlalasngdv
     4321 yawgsnsegq lglghtnhvr eptlvtglqg knvrqisagr chsaawtapp vpprapgvsv
     4381 plqlglpdtv ppqygalrev sihtvrarlr llyhfsdlmy sswrllnlsp nnqnstshyn
     4441 agtwgivqgq lrpllaprvy tlpmvrsigk tmvqgknygp qitvkristr grkckpifvq
     4501 iarqvvklna sdlrlpsraw kvklvgegad daggvfddti temcqeletg ivdllipspn
     4561 ataevgynrd rflfnpsacl dehlmqfkfl gilmgvairt kkpldlhlap lvwkqlccvp
     4621 ltledleevd llyvqtlnsi lhiedsgite esfhemipld sfvgqsadgk mvpiipggns
     4681 ipltfsnrke yveraieyrl hemdrqvaav regmswivpv pllslltakq leqmvcgmpe
     4741 isvevlkkvv ryrevdeqhq lvqwfwhtle efsneervlf mrfvsgrsrl pantadisqr
     4801 fqimkvdrpy dslptsqtcf fqlrlppyss qlvmaerlry ainncrsidm dnymlsrnvd
     4861 naegsdtdy
//
LOCUS       XP_047289207            4863 aa            linear   PRI 05-AUG-2025
DEFINITION  putative E3 ubiquitin-protein ligase HERC1 isoform X26 [Homo
            sapiens].
ACCESSION   XP_047289207
VERSION     XP_047289207.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433251.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4863
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4863
                     /product="putative E3 ubiquitin-protein ligase HERC1
                     isoform X26"
                     /calculated_mol_wt=532226
     Region          374..703
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          683..733
                     /region_name="RCC1"
                     /note="Regulator of chromosome condensation (RCC1) repeat;
                     pfam00415"
                     /db_xref="CDD:395335"
     Region          2041..2198
                     /region_name="SPRY_HERC1"
                     /note="SPRY domain in HERC1; cd12881"
                     /db_xref="CDD:293939"
     Region          2762..2805
                     /region_name="UBA_HERC1"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC1 and similar proteins; cd14401"
                     /db_xref="CDD:270584"
     Region          <3389..3780
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          3434..3477
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3491..3526
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3531..3578
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3587..3622
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3631..3667
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3674..3705
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3752..3788
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          4001..4337
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          4475..4843
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4480,4521,4532,4599,4777,4807..4808,4811..4815,4835,
                     4842)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4627,4630..4631,4633..4634,4637,4645,4647,
                     4651..4652,4654,4663,4668,4685,4689)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4863
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /coded_by="XM_047433251.1:149..14740"
                     /db_xref="GeneID:8925"
                     /db_xref="HGNC:HGNC:4867"
                     /db_xref="MIM:605109"
ORIGIN      
        1 matmippvkl kwlehlnssw itedsesiat regvavlysk lvsnkevvpl pqqvlclkgp
       61 qlpdferesl ssdeqdhyld allssqlala kmvcsdspfa galrkrllvl qrvfyalsnk
      121 yhdkgkvkqq qhspesssgs advhsvserp rsstdaliem gvrtglsllf allrqswmmp
      181 vsgpglslcn dvihtaievv sslpplslan eskippmgld clsqvttflk gvtipnsgad
      241 tlgrrlasel llglaaqrgs lryllewiem algasavvht mekgkllssq egmisfdcfm
      301 tilmqmrrsl gssadrsqwr eptrtsdglc slyeaalclf eevcrmasdy srtcaspdsi
      361 qtgdapivse tcevyvwgsn sshqlvegtq ekilqpklap sfsdaqtiea gqyctfvist
      421 dgsvracgkg sygrlglgds nnqstlkklt fephrsikkv ssskgsdght lafttegevf
      481 swgdgdygkl ghgnsstqky pkliqgplqg kvvvcvsagy rhsaavtedg elytwgegdf
      541 grlghgdsns rniptlvkdi snvgevscgs shtialskdg rtvwsfgggd ngklghgdtn
      601 rvykpkviea lqgmfirkvc agsqsslalt stgqvyawgc gaclgcgsse atalrpklie
      661 elaatrivdv sigdshclal shdnevyawg nnsmgqcgqg nstgpitkpk kvsgldgiai
      721 qqisagtshs lawtalprdr qvvawhrpyc vdleestfsh lrsflerycd kinseipplp
      781 fpssrehhsf lklclkllsn hlalalaggv atsilgrqag plrnllfrlm dstvpdeiqe
      841 vvietlsvga tmllpplrer mellhsllpq gpdrweslsk gqrmqldiil tslqdhthva
      901 sllgysspsd aadlssvctg ygnlsdqpyg tqschpdthl aeilmktllr nlgfytdqaf
      961 geleknsdkf llgtsssens qpahlhellc slqkqllafc hinnisenss svallhkhlq
     1021 lllphatdiy srsanllkes pwngsvgekl rdviyvsaag smlcqivnsl lllpvsvarp
     1081 llsylldllp pldclnrllp aadlledqel qwplhggpel idpaglplpq paqswvwlvd
     1141 lertiallig rclggmlqgs pvspeeqdta ywmktplfsd gvemdtpqld kcmsclleva
     1201 lsgneeqkpf dyklrpeiav yvdlalgcsk eparslwism qdyavskdwd satlsnesll
     1261 dtvsrfvlaa llkhtnllsq acgesryqpg khlsevyrcv ykvrsrllac knleliqtrs
     1321 ssrdrwisen qdsadvdpqe hsftrtidee aemeeqaerd reeghpeped eeeerehevm
     1381 tagnlvfvlh vteifqcfls arevarsrdr drmnsgagsg araddpppqs qqerrvstdl
     1441 pegqdvytaa cnsvihrcal lilgvspvid elqkrreegq lqqpstsase ggglmtrses
     1501 ltaesrlvht spnyrliksr sesdlsqpes deegyalsgr rnvdldlaas hrkrgpmhsq
     1561 leslsdswar lkhsrdwlcn ssysfesdfd ltkslgvhtl ienvvsfvsg dvgnapgfke
     1621 peesmstspq asiiameqqq lraelrleal hqilvllsgm eekgsislag srlssgfqss
     1681 tlltsvrlqf lagcfglgtv ghtggkgesg rlhhyqdgir aakrniqiei qvavhkiyqq
     1741 lsatleralq ankhhieaqq rlllvtvfal svhyqpvdvs laistgllnv lsqlcgtdtm
     1801 lgqplqllpk tgvsqlstal kvastrllqi laittgtyad klspkvvqsl ldllcsqlkn
     1861 llsqtgvlhm asfgegeqed geeeekkvds sgetekkdfr aalrkqhaae lhlgdflvfl
     1921 rrvvsskaiq skmaspkwte vllniasqkc ssgiplvgnl rtrllalhvl eavlpacesg
     1981 veddqmaqiv erlfsllsdc mwetpiaqak haiqikekeq eiklqkqgel eeedenlpiq
     2041 evsfdpekaq cclvengqil thgsggkgyg lastgvtsgc yqwkfyivke nrgnegtcvg
     2101 vsrwpvhdfn hrttsdmwly raysgnlyhn geqtltlssf tqgdfitcvl dmeartisfg
     2161 kngeepklaf edvdaaelyp cvmfyssnpg ekvkicdmqm rgtprdllpg dpicspvaav
     2221 laeatiqlir ilhrtdrwty cinkkmmerl hkikicikes gqklkksrsv qsreenemre
     2281 ekeskeeekg khtrhgladl selqlrtlci evwpvlavig gvdaglrvgg rcvhkqtgrh
     2341 atllgvvkeg stsakvqwde aeitisfptf wspsdtplyn lepceplpfd varfrgltas
     2401 vlldltyltg vhedmgkqst krhekkhrhe seekgdveqk pesesaldmr tgltsddvks
     2461 qsttssksen eiasfsldpt lpsvesqhqi tegkrknheh msknhdvaqs eiravqlsyl
     2521 ylgamkslsa llgcskyael llipkvlaen ghnsdcassp vvhedvemra alqflmrhmv
     2581 kravmrspik ralgladler aqamiyklvv hglledqfgg kikqeidqqa eesdpaqqaq
     2641 tpvttspsas sttsfmsssl edtttattpv tdtetvpase spgvmplsll rqmfssyptt
     2701 tvlptrraqt ppisslptsp sdevgrrqsl tspdsqsarp anrtalsdps srlstspppp
     2761 aiavpllemg fslrqiakam eatgargead aqnitvlamw miehpghede eepqsgstad
     2821 srpgaavlgs ggksndpcyl qspgdipsad aaemeegfse spdnldhten aasgsgpsar
     2881 grsavtrrhk fdlaartlla raaglyrsvq ahrnqsrreg islqqdpgal ydfnldeele
     2941 idlddeamea mfgqdltsdn dilgmwipeh vcesedreev vvcelcecsv vsfnqhmkrn
     3001 hpgcgrsanr qgyrsngsyv dgwfggecgs gnpyyllcgt crekylamkt kskstssery
     3061 kgqapdligk qdsvyeedwd mldvdedekl tgeeefella gplglndrri vpepvqfpds
     3121 dplgasvamv tatnsmeetl mqigchgsve ksssgritlg eqaaalanph drvvalrrvt
     3181 aaaqvllart mvmralslls vsgsscslaa gleslgltdi rtlvrlmcla aagraglsts
     3241 psamastser srgghskank pisclaylst avgclasnap saakllvqlc tqnlisaatg
     3301 vnlttvddsi qrkflpsflr giaeenklvt spnfvvtqal valladkgak lrpnydksev
     3361 ekkgplelan alaacclssr lssqhrqwaa qqlvrtlaah drdnqttlqt ladmggdlrk
     3421 csfikleahq nrvmtcvwcn kkgllatsgn dgtirvwnvt kkqyslqqtc vfnrlegdae
     3481 eslgspsdps fspvswsisg kylagalekm vniwqvnggk glvdiqphwv salawpeegp
     3541 atawsgespe lllvgrmdgs lglievvdvs tmhrrelehc yrkdvsvtci awfsedrpfa
     3601 vgyfdgklll gtkeplekgg ivlidahkdt lismkwdptg hilmtcaked svklwgsisg
     3661 cwcclhslch psivngiawc rlpgkgsklq llmatgcqsg lvcvwripqd ttqtnvtsae
     3721 gwweqesncq dgyrkssgak cvyqlrghit pvrtvafssd glalvsgglg glmniwslrd
     3781 gsvlqtvvig sgaiqttvwi pevgvaacsn rskdvlvvnc taewaaanhv latcrtalkq
     3841 qgvlglnmap cmraflerlp mmlqeqyaye kphvvcgdql vhspymqcla slavglhldq
     3901 llcnppvpph hqnclpdpas wnpnewawle cfsttikaae altngaqfpe sftvpdlepv
     3961 pedelvflmd nskwingmde qimswatsrp edwhlggkcd vylwgagrhg qlaeagrnvm
     4021 vpaaapsfsq aqqvicgqnc tfviqangtv lacgegsygr lgqgnsddlh vltvisalqg
     4081 fvvtqlvtsc gsdghsmalt esgevfswgd gdygklghgn sdrqrrprqi ealqgeevvq
     4141 mscgfkhsav vtsdgklftf gngdygrlgl gntsnkklpe rvtalegyqi gqvacglnht
     4201 lavsadgsmv wafgdgdygk lglgnstaks spqkidvlcg igikkvacgt qfsvaltkdg
     4261 hvytfgqdrl iglpegrarn hnrpqqipvl agviiedvav gaehtlalas ngdvyawgsn
     4321 segqlglght nhvreptlvt glqgknvrqi sagrchsaaw tappvpprap gvsvplqlgl
     4381 pdtvppqyga lrevsihtvr arlrllyhfs dlmysswrll nlspnnqnst shynagtwgi
     4441 vqgqlrplla prvytlpmvr sigktmvqgk nygpqitvkr istrgrkckp ifvqiarqvv
     4501 klnasdlrlp srawkvklvg egaddaggvf ddtitemcqe letgivdlli pspnataevg
     4561 ynrdrflfnp sacldehlmq fkflgilmgv airtkkpldl hlaplvwkql ccvpltledl
     4621 eevdllyvqt lnsilhieds giteesfhem ipldsfvgqs adgkmvpiip ggnsipltfs
     4681 nrkeyverai eyrlhemdrq vaavregmsw ivpvpllsll takqleqmvc gmpeisvevl
     4741 kkvvryrevd eqhqlvqwfw htleefsnee rvlfmrfvsg rsrlpantad isqrfqimkv
     4801 drpydslpts qtcffqlrlp pyssqlvmae rlryainncr sidmdnymls rnvdnaegsd
     4861 tdy
//
LOCUS       XP_047289208            4863 aa            linear   PRI 05-AUG-2025
DEFINITION  putative E3 ubiquitin-protein ligase HERC1 isoform X27 [Homo
            sapiens].
ACCESSION   XP_047289208
VERSION     XP_047289208.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433252.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4863
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4863
                     /product="putative E3 ubiquitin-protein ligase HERC1
                     isoform X27"
                     /calculated_mol_wt=532036
     Region          374..703
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          683..733
                     /region_name="RCC1"
                     /note="Regulator of chromosome condensation (RCC1) repeat;
                     pfam00415"
                     /db_xref="CDD:395335"
     Region          2032..2189
                     /region_name="SPRY_HERC1"
                     /note="SPRY domain in HERC1; cd12881"
                     /db_xref="CDD:293939"
     Region          2745..2788
                     /region_name="UBA_HERC1"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC1 and similar proteins; cd14401"
                     /db_xref="CDD:270584"
     Region          <3389..3780
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          3434..3477
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3491..3526
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3531..3578
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3587..3622
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3631..3667
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3674..3705
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3752..3788
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          4001..4337
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          4475..4843
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4480,4521,4532,4599,4777,4807..4808,4811..4815,4835,
                     4842)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4627,4630..4631,4633..4634,4637,4645,4647,
                     4651..4652,4654,4663,4668,4685,4689)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4863
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /coded_by="XM_047433252.1:149..14740"
                     /db_xref="GeneID:8925"
                     /db_xref="HGNC:HGNC:4867"
                     /db_xref="MIM:605109"
ORIGIN      
        1 matmippvkl kwlehlnssw itedsesiat regvavlysk lvsnkevvpl pqqvlclkgp
       61 qlpdferesl ssdeqdhyld allssqlala kmvcsdspfa galrkrllvl qrvfyalsnk
      121 yhdkgkvkqq qhspesssgs advhsvserp rsstdaliem gvrtglsllf allrqswmmp
      181 vsgpglslcn dvihtaievv sslpplslan eskippmgld clsqvttflk gvtipnsgad
      241 tlgrrlasel llglaaqrgs lryllewiem algasavvht mekgkllssq egmisfdcfm
      301 tilmqmrrsl gssadrsqwr eptrtsdglc slyeaalclf eevcrmasdy srtcaspdsi
      361 qtgdapivse tcevyvwgsn sshqlvegtq ekilqpklap sfsdaqtiea gqyctfvist
      421 dgsvracgkg sygrlglgds nnqstlkklt fephrsikkv ssskgsdght lafttegevf
      481 swgdgdygkl ghgnsstqky pkliqgplqg kvvvcvsagy rhsaavtedg elytwgegdf
      541 grlghgdsns rniptlvkdi snvgevscgs shtialskdg rtvwsfgggd ngklghgdtn
      601 rvykpkviea lqgmfirkvc agsqsslalt stgqvyawgc gaclgcgsse atalrpklie
      661 elaatrivdv sigdshclal shdnevyawg nnsmgqcgqg nstgpitkpk kvsgldgiai
      721 qqisagtshs lawtalprdr qvvawhrpyc vdleestfsh lrsflerycd kinseipplp
      781 fpssrehhsf lklclkllsn hlalalaggv atsilgrqag plrnllfrlm dstvpdeiqe
      841 vvietlsvga tmllpplrer mellhsllpq gpdrweslsk gqrmqldiil tslqdhthva
      901 sllgysspsd aadlssvctg ygnlsdqpyg tqschpdthl aeilmktllr nlgfytdqaf
      961 geleknsdkf llgtsssens qpahlhellc slqkqllafc hinnisenss svallhkhlq
     1021 lllphatdiy srsanllkes pwngsvgekl rdviyvsaag smlcqivnsl lllpvsvarp
     1081 llsylldllp pldclnrllp aadlledqel qwplhggpel idpaglplpq paqswvwlvd
     1141 lertiallig rclggmlqgs pvspeeqdta ywmktplfsd gvemdtpqld kcmsclleva
     1201 lsgneeqkpf dyklrpeiav yvdlalgcsk eparslwism qdyavskdwd satlsnesll
     1261 dtvsrfvlaa llkhtnllsq acgesryqpg khlsevyrcv ykvrsrllac knleliqtrs
     1321 ssrdrwisen qdsadvdpqe hsftrtidee aemeeqaerd reeghpeped eeeerehevm
     1381 tagkifqcfl sarevarsrd rdrmnsgags garaddpppq sqqerrvstd lpegqdvyta
     1441 acnsvihrca llilgvspvi delqkrreeg qlqqpstsas eggglmtrse sltaesrlvh
     1501 tspnyrliks rsesdlsqpe sdeegyalsg rrnvdldlaa shrkrgpmhs qleslsdswa
     1561 rlkhsrdwlc nssysfesdf dltkslgvht lienvvsfvs gdvgnapgfk epeesmstsp
     1621 qasiiameqq qlraelrlea lhqilvllsg meekgsisla gsrlssgfqs stlltsvrlq
     1681 flagcfglgt vghtggkges grlhhyqdgi raakrniqie iqvavhkiyq qlsatleral
     1741 qankhhieaq qrlllvtvfa lsvhyqpvdv slaistglln vlsqlcgtdt mlgqplqllp
     1801 ktgvsqlsta lkvastrllq ilaittgtya dklspkvvqs lldllcsqlk nllsqtgvlh
     1861 masfgegeqe dgeeeekkvd ssgetekkdf raalrkqhaa elhlgdflvf lrrvvsskai
     1921 qskmaspkwt evllniasqk cssgiplvgn lrtrllalhv leavlpaces gveddqmaqi
     1981 verlfsllsd cmwetpiaqa khaiqikeke qeiklqkqge leeedenlpi qevsfdpeka
     2041 qcclvengqi lthgsggkgy glastgvtsg cyqwkfyivk enrgnegtcv gvsrwpvhdf
     2101 nhrttsdmwl yraysgnlyh ngeqtltlss ftqgdfitcv ldmeartisf gkngeepkla
     2161 fedvdaaely pcvmfyssnp gekvkicdmq mrgtprdllp gdpicspvaa vlaeatiqli
     2221 rilhrtdrwt ycinkkmmer lhkikicike sgqklkksrs vqsreenemr eekeskeeek
     2281 gkhtrhglad lselqlrtlc ievwpvlavi ggvdaglrvg grcvhkqtgr hatllgvvke
     2341 gstsakvqwd eaeitisdtp lynlepcepl pfdvarfrgl tasvlldlty ltgvhedmgk
     2401 qstkrhekkh rheseekgdv eqkpesesal dmrtgltsdd vksqsttssk seneiasfsl
     2461 dptlpsvesq hqitegkrkn hehmsknhdv aqseiravql sylylgamks lsallgcsky
     2521 aelllipkvl aenghnsdca sspvvhedve mraalqflmr hmvkravmrs pikralglad
     2581 leraqamiyk lvvhglledq fggkikqeid qqaeesdpaq qaqtpvttsp sassttsfms
     2641 ssledtttat tpvtdtetvp asespgvmpl sllrqmfssy ptttvlptrr aqtppisslp
     2701 tspsdevgrr qsltspdsqs arpanrtals dpssrlstsp pppaiavpll emgfslrqia
     2761 kameatgarg eadaqnitvl amwmiehpgh edeeepqsgs tadsrpgaav lgsggksndp
     2821 cylqspgdip sadaaemeeg fsespdnldh tenaasgsgp sargrsavtr rhkfdlaart
     2881 llaraaglyr svqahrnqsr regislqqdp galydfnlde eleidlddea meamfgqdlt
     2941 sdndilgmwi pehvcesedr eevvvcelce csvvsfnqhm krnhpgcgrs anrqgyrsng
     3001 syvdgwfgge cgsgnpyyll cgtcrekyla mktkskstss erykgqapdl igkqdsvyee
     3061 dwdmldvded ekltgeeefe llagplglnd rrivpepvqf pdsdplgasv amvtatnsme
     3121 etlmqigchg sveksssgri tlgeqaaala nphdrvvalr rvtaaaqvll artmvmrals
     3181 llsvsgsscs laagleslgl tdirtlvrlm claaagragl stspsamast sersrgghsk
     3241 ankpisclay lstavgclas napsaakllv qlctqnlisa atgvnlttvd dsiqrkflps
     3301 flrgiaeenk lvtspnfvvt qalvalladk gaklrpnydk sevekkglia qlyahpsydp
     3361 savgplelan alaacclssr lssqhrqwaa qqlvrtlaah drdnqttlqt ladmggdlrk
     3421 csfikleahq nrvmtcvwcn kkgllatsgn dgtirvwnvt kkqyslqqtc vfnrlegdae
     3481 eslgspsdps fspvswsisg kylagalekm vniwqvnggk glvdiqphwv salawpeegp
     3541 atawsgespe lllvgrmdgs lglievvdvs tmhrrelehc yrkdvsvtci awfsedrpfa
     3601 vgyfdgklll gtkeplekgg ivlidahkdt lismkwdptg hilmtcaked svklwgsisg
     3661 cwcclhslch psivngiawc rlpgkgsklq llmatgcqsg lvcvwripqd ttqtnvtsae
     3721 gwweqesncq dgyrkssgak cvyqlrghit pvrtvafssd glalvsgglg glmniwslrd
     3781 gsvlqtvvig sgaiqttvwi pevgvaacsn rskdvlvvnc taewaaanhv latcrtalkq
     3841 qgvlglnmap cmraflerlp mmlqeqyaye kphvvcgdql vhspymqcla slavglhldq
     3901 llcnppvpph hqnclpdpas wnpnewawle cfsttikaae altngaqfpe sftvpdlepv
     3961 pedelvflmd nskwingmde qimswatsrp edwhlggkcd vylwgagrhg qlaeagrnvm
     4021 vpaaapsfsq aqqvicgqnc tfviqangtv lacgegsygr lgqgnsddlh vltvisalqg
     4081 fvvtqlvtsc gsdghsmalt esgevfswgd gdygklghgn sdrqrrprqi ealqgeevvq
     4141 mscgfkhsav vtsdgklftf gngdygrlgl gntsnkklpe rvtalegyqi gqvacglnht
     4201 lavsadgsmv wafgdgdygk lglgnstaks spqkidvlcg igikkvacgt qfsvaltkdg
     4261 hvytfgqdrl iglpegrarn hnrpqqipvl agviiedvav gaehtlalas ngdvyawgsn
     4321 segqlglght nhvreptlvt glqgknvrqi sagrchsaaw tappvpprap gvsvplqlgl
     4381 pdtvppqyga lrevsihtvr arlrllyhfs dlmysswrll nlspnnqnst shynagtwgi
     4441 vqgqlrplla prvytlpmvr sigktmvqgk nygpqitvkr istrgrkckp ifvqiarqvv
     4501 klnasdlrlp srawkvklvg egaddaggvf ddtitemcqe letgivdlli pspnataevg
     4561 ynrdrflfnp sacldehlmq fkflgilmgv airtkkpldl hlaplvwkql ccvpltledl
     4621 eevdllyvqt lnsilhieds giteesfhem ipldsfvgqs adgkmvpiip ggnsipltfs
     4681 nrkeyverai eyrlhemdrq vaavregmsw ivpvpllsll takqleqmvc gmpeisvevl
     4741 kkvvryrevd eqhqlvqwfw htleefsnee rvlfmrfvsg rsrlpantad isqrfqimkv
     4801 drpydslpts qtcffqlrlp pyssqlvmae rlryainncr sidmdnymls rnvdnaegsd
     4861 tdy
//
LOCUS       XP_047289210            4862 aa            linear   PRI 05-AUG-2025
DEFINITION  putative E3 ubiquitin-protein ligase HERC1 isoform X28 [Homo
            sapiens].
ACCESSION   XP_047289210
VERSION     XP_047289210.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433254.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4862
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4862
                     /product="putative E3 ubiquitin-protein ligase HERC1
                     isoform X28"
                     /calculated_mol_wt=532174
     Region          374..703
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          683..733
                     /region_name="RCC1"
                     /note="Regulator of chromosome condensation (RCC1) repeat;
                     pfam00415"
                     /db_xref="CDD:395335"
     Region          2041..2198
                     /region_name="SPRY_HERC1"
                     /note="SPRY domain in HERC1; cd12881"
                     /db_xref="CDD:293939"
     Region          2754..2797
                     /region_name="UBA_HERC1"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC1 and similar proteins; cd14401"
                     /db_xref="CDD:270584"
     Region          <3388..3779
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          3433..3476
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3490..3525
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3530..3577
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3586..3621
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3630..3666
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3673..3704
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3751..3787
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          4000..4336
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          4474..4842
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4479,4520,4531,4598,4776,4806..4807,4810..4814,4834,
                     4841)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4626,4629..4630,4632..4633,4636,4644,4646,
                     4650..4651,4653,4662,4667,4684,4688)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4862
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /coded_by="XM_047433254.1:154..14742"
                     /db_xref="GeneID:8925"
                     /db_xref="HGNC:HGNC:4867"
                     /db_xref="MIM:605109"
ORIGIN      
        1 matmippvkl kwlehlnssw itedsesiat regvavlysk lvsnkevvpl pqqvlclkgp
       61 qlpdferesl ssdeqdhyld allssqlala kmvcsdspfa galrkrllvl qrvfyalsnk
      121 yhdkgkvkqq qhspesssgs advhsvserp rsstdaliem gvrtglsllf allrqswmmp
      181 vsgpglslcn dvihtaievv sslpplslan eskippmgld clsqvttflk gvtipnsgad
      241 tlgrrlasel llglaaqrgs lryllewiem algasavvht mekgkllssq egmisfdcfm
      301 tilmqmrrsl gssadrsqwr eptrtsdglc slyeaalclf eevcrmasdy srtcaspdsi
      361 qtgdapivse tcevyvwgsn sshqlvegtq ekilqpklap sfsdaqtiea gqyctfvist
      421 dgsvracgkg sygrlglgds nnqstlkklt fephrsikkv ssskgsdght lafttegevf
      481 swgdgdygkl ghgnsstqky pkliqgplqg kvvvcvsagy rhsaavtedg elytwgegdf
      541 grlghgdsns rniptlvkdi snvgevscgs shtialskdg rtvwsfgggd ngklghgdtn
      601 rvykpkviea lqgmfirkvc agsqsslalt stgqvyawgc gaclgcgsse atalrpklie
      661 elaatrivdv sigdshclal shdnevyawg nnsmgqcgqg nstgpitkpk kvsgldgiai
      721 qqisagtshs lawtalprdr qvvawhrpyc vdleestfsh lrsflerycd kinseipplp
      781 fpssrehhsf lklclkllsn hlalalaggv atsilgrqag plrnllfrlm dstvpdeiqe
      841 vvietlsvga tmllpplrer mellhsllpq gpdrweslsk gqrmqldiil tslqdhthva
      901 sllgysspsd aadlssvctg ygnlsdqpyg tqschpdthl aeilmktllr nlgfytdqaf
      961 geleknsdkf llgtsssens qpahlhellc slqkqllafc hinnisenss svallhkhlq
     1021 lllphatdiy srsanllkes pwngsvgekl rdviyvsaag smlcqivnsl lllpvsvarp
     1081 llsylldllp pldclnrllp aadlledqel qwplhggpel idpaglplpq paqswvwlvd
     1141 lertiallig rclggmlqgs pvspeeqdta ywmktplfsd gvemdtpqld kcmsclleva
     1201 lsgneeqkpf dyklrpeiav yvdlalgcsk eparslwism qdyavskdwd satlsnesll
     1261 dtvsrfvlaa llkhtnllsq acgesryqpg khlsevyrcv ykvrsrllac knleliqtrs
     1321 ssrdrwisen qdsadvdpqe hsftrtidee aemeeqaerd reeghpeped eeeerehevm
     1381 tagnlvfvlh vteifqcfls arevarsrdr drmnsgagsg araddpppqs qqerrvstdl
     1441 pegqdvytaa cnsvihrcal lilgvspvid elqkrreegq lqqpstsase ggglmtrses
     1501 ltaesrlvht spnyrliksr sesdlsqpes deegyalsgr rnvdldlaas hrkrgpmhsq
     1561 leslsdswar lkhsrdwlcn ssysfesdfd ltkslgvhtl ienvvsfvsg dvgnapgfke
     1621 peesmstspq asiiameqqq lraelrleal hqilvllsgm eekgsislag srlssgfqss
     1681 tlltsvrlqf lagcfglgtv ghtggkgesg rlhhyqdgir aakrniqiei qvavhkiyqq
     1741 lsatleralq ankhhieaqq rlllvtvfal svhyqpvdvs laistgllnv lsqlcgtdtm
     1801 lgqplqllpk tgvsqlstal kvastrllqi laittgtyad klspkvvqsl ldllcsqlkn
     1861 llsqtgvlhm asfgegeqed geeeekkvds sgetekkdfr aalrkqhaae lhlgdflvfl
     1921 rrvvsskaiq skmaspkwte vllniasqkc ssgiplvgnl rtrllalhvl eavlpacesg
     1981 veddqmaqiv erlfsllsdc mwetpiaqak haiqikekeq eiklqkqgel eeedenlpiq
     2041 evsfdpekaq cclvengqil thgsggkgyg lastgvtsgc yqwkfyivke nrgnegtcvg
     2101 vsrwpvhdfn hrttsdmwly raysgnlyhn geqtltlssf tqgdfitcvl dmeartisfg
     2161 kngeepklaf edvdaaelyp cvmfyssnpg ekvkicdmqm rgtprdllpg dpicspvaav
     2221 laeatiqlir ilhrtdrwty cinkkmmerl hkikicikes gqklkksrsv qsreenemre
     2281 ekeskeeekg khtrhgladl selqlrtlci evwpvlavig gvdaglrvgg rcvhkqtgrh
     2341 atllgvvkeg stsakvqwde aeitisdtpl ynlepceplp fdvarfrglt asvlldltyl
     2401 tgvhedmgkq stkrhekkhr heseekgdve qkpesesald mrtgltsddv ksqsttssks
     2461 eneiasfsld ptlpsvesqh qitegkrknh ehmsknhdva qseiravqls ylylgamksl
     2521 sallgcskya elllipkvla enghnsdcas spvvhedvem raalqflmrh mvkravmrsp
     2581 ikralgladl eraqamiykl vvhglledqf ggkikqeidq qaeesdpaqq aqtpvttsps
     2641 assttsfmss sledtttatt pvtdtetvpa sespgvmpls llrqmfssyp tttvlptrra
     2701 qtppisslpt spsdevgrrq sltspdsqsa rpanrtalsd pssrlstspp ppaiavplle
     2761 mgfslrqiak ameatgarge adaqnitvla mwmiehpghe deeepqsgst adsrpgaavl
     2821 gsggksndpc ylqspgdips adaaemeegf sespdnldht enaasgsgps argrsavtrr
     2881 hkfdlaartl laraaglyrs vqahrnqsrr egislqqdpg alydfnldee leidlddeam
     2941 eamfgqdlts dndilgmwip evldwptwhv cesedreevv vcelcecsvv sfnqhmkrnh
     3001 pgcgrsanrq gyrsngsyvd gwfggecgsg npyyllcgtc rekylamktk skstsseryk
     3061 gqapdligkq dsvyeedwdm ldvdedeklt geeefellag plglndrriv pepvqfpdsd
     3121 plgasvamvt atnsmeetlm qigchgsvek sssgritlge qaaalanphd rvvalrrvta
     3181 aaqvllartm vmralsllsv sgsscslaag leslgltdir tlvrlmclaa agraglstsp
     3241 samastsers rgghskankp isclaylsta vgclasnaps aakllvqlct qnlisaatgv
     3301 nlttvddsiq rkflpsflrg iaeenklvts pnfvvtqalv alladkgakl rpnydkseve
     3361 kkgplelana laacclssrl ssqhrqwaaq qlvrtlaahd rdnqttlqtl admggdlrkc
     3421 sfikleahqn rvmtcvwcnk kgllatsgnd gtirvwnvtk kqyslqqtcv fnrlegdaee
     3481 slgspsdpsf spvswsisgk ylagalekmv niwqvnggkg lvdiqphwvs alawpeegpa
     3541 tawsgespel llvgrmdgsl glievvdvst mhrrelehcy rkdvsvtcia wfsedrpfav
     3601 gyfdgklllg tkeplekggi vlidahkdtl ismkwdptgh ilmtcakeds vklwgsisgc
     3661 wcclhslchp sivngiawcr lpgkgsklql lmatgcqsgl vcvwripqdt tqtnvtsaeg
     3721 wweqesncqd gyrkssgakc vyqlrghitp vrtvafssdg lalvsgglgg lmniwslrdg
     3781 svlqtvvigs gaiqttvwip evgvaacsnr skdvlvvnct aewaaanhvl atcrtalkqq
     3841 gvlglnmapc mraflerlpm mlqeqyayek phvvcgdqlv hspymqclas lavglhldql
     3901 lcnppvpphh qnclpdpasw npnewawlec fsttikaaea ltngaqfpes ftvpdlepvp
     3961 edelvflmdn skwingmdeq imswatsrpe dwhlggkcdv ylwgagrhgq laeagrnvmv
     4021 paaapsfsqa qqvicgqnct fviqangtvl acgegsygrl gqgnsddlhv ltvisalqgf
     4081 vvtqlvtscg sdghsmalte sgevfswgdg dygklghgns drqrrprqie alqgeevvqm
     4141 scgfkhsavv tsdgklftfg ngdygrlglg ntsnkklper vtalegyqig qvacglnhtl
     4201 avsadgsmvw afgdgdygkl glgnstakss pqkidvlcgi gikkvacgtq fsvaltkdgh
     4261 vytfgqdrli glpegrarnh nrpqqipvla gviiedvavg aehtlalasn gdvyawgsns
     4321 egqlglghtn hvreptlvtg lqgknvrqis agrchsaawt appvpprapg vsvplqlglp
     4381 dtvppqygal revsihtvra rlrllyhfsd lmysswrlln lspnnqnsts hynagtwgiv
     4441 qgqlrpllap rvytlpmvrs igktmvqgkn ygpqitvkri strgrkckpi fvqiarqvvk
     4501 lnasdlrlps rawkvklvge gaddaggvfd dtitemcqel etgivdllip spnataevgy
     4561 nrdrflfnps acldehlmqf kflgilmgva irtkkpldlh laplvwkqlc cvpltledle
     4621 evdllyvqtl nsilhiedsg iteesfhemi pldsfvgqsa dgkmvpiipg gnsipltfsn
     4681 rkeyveraie yrlhemdrqv aavregmswi vpvpllsllt akqleqmvcg mpeisvevlk
     4741 kvvryrevde qhqlvqwfwh tleefsneer vlfmrfvsgr srlpantadi sqrfqimkvd
     4801 rpydslptsq tcffqlrlpp yssqlvmaer lryainncrs idmdnymlsr nvdnaegsdt
     4861 dy
//
LOCUS       XP_047289211            4854 aa            linear   PRI 05-AUG-2025
DEFINITION  putative E3 ubiquitin-protein ligase HERC1 isoform X29 [Homo
            sapiens].
ACCESSION   XP_047289211
VERSION     XP_047289211.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433255.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4854
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4854
                     /product="putative E3 ubiquitin-protein ligase HERC1
                     isoform X29"
                     /calculated_mol_wt=531202
     Region          374..703
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          683..733
                     /region_name="RCC1"
                     /note="Regulator of chromosome condensation (RCC1) repeat;
                     pfam00415"
                     /db_xref="CDD:395335"
     Region          2032..2189
                     /region_name="SPRY_HERC1"
                     /note="SPRY domain in HERC1; cd12881"
                     /db_xref="CDD:293939"
     Region          2753..2796
                     /region_name="UBA_HERC1"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC1 and similar proteins; cd14401"
                     /db_xref="CDD:270584"
     Region          <3380..3771
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          3425..3468
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3482..3517
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3522..3569
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3578..3613
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3622..3658
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3665..3696
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3743..3779
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3992..4328
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          4466..4834
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4471,4512,4523,4590,4768,4798..4799,4802..4806,4826,
                     4833)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4618,4621..4622,4624..4625,4628,4636,4638,
                     4642..4643,4645,4654,4659,4676,4680)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4854
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /coded_by="XM_047433255.1:149..14713"
                     /db_xref="GeneID:8925"
                     /db_xref="HGNC:HGNC:4867"
                     /db_xref="MIM:605109"
ORIGIN      
        1 matmippvkl kwlehlnssw itedsesiat regvavlysk lvsnkevvpl pqqvlclkgp
       61 qlpdferesl ssdeqdhyld allssqlala kmvcsdspfa galrkrllvl qrvfyalsnk
      121 yhdkgkvkqq qhspesssgs advhsvserp rsstdaliem gvrtglsllf allrqswmmp
      181 vsgpglslcn dvihtaievv sslpplslan eskippmgld clsqvttflk gvtipnsgad
      241 tlgrrlasel llglaaqrgs lryllewiem algasavvht mekgkllssq egmisfdcfm
      301 tilmqmrrsl gssadrsqwr eptrtsdglc slyeaalclf eevcrmasdy srtcaspdsi
      361 qtgdapivse tcevyvwgsn sshqlvegtq ekilqpklap sfsdaqtiea gqyctfvist
      421 dgsvracgkg sygrlglgds nnqstlkklt fephrsikkv ssskgsdght lafttegevf
      481 swgdgdygkl ghgnsstqky pkliqgplqg kvvvcvsagy rhsaavtedg elytwgegdf
      541 grlghgdsns rniptlvkdi snvgevscgs shtialskdg rtvwsfgggd ngklghgdtn
      601 rvykpkviea lqgmfirkvc agsqsslalt stgqvyawgc gaclgcgsse atalrpklie
      661 elaatrivdv sigdshclal shdnevyawg nnsmgqcgqg nstgpitkpk kvsgldgiai
      721 qqisagtshs lawtalprdr qvvawhrpyc vdleestfsh lrsflerycd kinseipplp
      781 fpssrehhsf lklclkllsn hlalalaggv atsilgrqag plrnllfrlm dstvpdeiqe
      841 vvietlsvga tmllpplrer mellhsllpq gpdrweslsk gqrmqldiil tslqdhthva
      901 sllgysspsd aadlssvctg ygnlsdqpyg tqschpdthl aeilmktllr nlgfytdqaf
      961 geleknsdkf llgtsssens qpahlhellc slqkqllafc hinnisenss svallhkhlq
     1021 lllphatdiy srsanllkes pwngsvgekl rdviyvsaag smlcqivnsl lllpvsvarp
     1081 llsylldllp pldclnrllp aadlledqel qwplhggpel idpaglplpq paqswvwlvd
     1141 lertiallig rclggmlqgs pvspeeqdta ywmktplfsd gvemdtpqld kcmsclleva
     1201 lsgneeqkpf dyklrpeiav yvdlalgcsk eparslwism qdyavskdwd satlsnesll
     1261 dtvsrfvlaa llkhtnllsq acgesryqpg khlsevyrcv ykvrsrllac knleliqtrs
     1321 ssrdrwisen qdsadvdpqe hsftrtidee aemeeqaerd reeghpeped eeeerehevm
     1381 tagkifqcfl sarevarsrd rdrmnsgags garaddpppq sqqerrvstd lpegqdvyta
     1441 acnsvihrca llilgvspvi delqkrreeg qlqqpstsas eggglmtrse sltaesrlvh
     1501 tspnyrliks rsesdlsqpe sdeegyalsg rrnvdldlaa shrkrgpmhs qleslsdswa
     1561 rlkhsrdwlc nssysfesdf dltkslgvht lienvvsfvs gdvgnapgfk epeesmstsp
     1621 qasiiameqq qlraelrlea lhqilvllsg meekgsisla gsrlssgfqs stlltsvrlq
     1681 flagcfglgt vghtggkges grlhhyqdgi raakrniqie iqvavhkiyq qlsatleral
     1741 qankhhieaq qrlllvtvfa lsvhyqpvdv slaistglln vlsqlcgtdt mlgqplqllp
     1801 ktgvsqlsta lkvastrllq ilaittgtya dklspkvvqs lldllcsqlk nllsqtgvlh
     1861 masfgegeqe dgeeeekkvd ssgetekkdf raalrkqhaa elhlgdflvf lrrvvsskai
     1921 qskmaspkwt evllniasqk cssgiplvgn lrtrllalhv leavlpaces gveddqmaqi
     1981 verlfsllsd cmwetpiaqa khaiqikeke qeiklqkqge leeedenlpi qevsfdpeka
     2041 qcclvengqi lthgsggkgy glastgvtsg cyqwkfyivk enrgnegtcv gvsrwpvhdf
     2101 nhrttsdmwl yraysgnlyh ngeqtltlss ftqgdfitcv ldmeartisf gkngeepkla
     2161 fedvdaaely pcvmfyssnp gekvkicdmq mrgtprdllp gdpicspvaa vlaeatiqli
     2221 rilhrtdrwt ycinkkmmer lhkikicike sgqklkksrs vqsreenemr eekeskeeek
     2281 gkhtrhglad lselqlrtlc ievwpvlavi ggvdaglrvg grcvhkqtgr hatllgvvke
     2341 gstsakvqwd eaeitisfpt fwspsdtply nlepceplpf dvarfrglta svlldltylt
     2401 gvhedmgkqs tkrhekkhrh eseekgdveq kpesesaldm rtgltsddvk sqsttsskse
     2461 neiasfsldp tlpsvesqhq itegkrknhe hmsknhdvaq seiravqlsy lylgamksls
     2521 allgcskyae lllipkvlae nghnsdcass pvvhedvemr aalqflmrhm vkravmrspi
     2581 kralgladle raqamiyklv vhglledqfg gkikqeidqq aeesdpaqqa qtpvttspsa
     2641 ssttsfmsss ledtttattp vtdtetvpas espgvmplsl lrqmfssypt ttvlptrraq
     2701 tppisslpts psdevgrrqs ltspdsqsar panrtalsdp ssrlstsppp paiavpllem
     2761 gfslrqiaka meatgargea daqnitvlam wmiehpghed eeepqsgsta dsrpgaavlg
     2821 sggksndpcy lqspgdipsa daaemeegfs espdnldhte naasgsgpsa rgrsavtrrh
     2881 kfdlaartll araaglyrsv qahrnqsrre gislqqdpga lydfnldeel eidlddeame
     2941 amfgqdltsd ndilgmwipe hvcesedree vvvcelcecs vvsfnqhmkr nhpgcgrsan
     3001 rqgyrsngsy vdgwfggecg sgnpyyllcg tcrekylamk tkskstsser ykgqapdlig
     3061 kqdsvyeedw dmldvdedek ltgeeefell agplglndrr ivpepvqfpd sdplgasvam
     3121 vtatnsmeet lmqigchgsv eksssgritl geqaaalanp hdrvvalrrv taaaqvllar
     3181 tmvmralsll svsgsscsla agleslgltd irtlvrlmcl aaagraglst spsamastse
     3241 rsrgghskan kpisclayls tavgclasna psaakllvql ctqnlisaat gvnlttvdds
     3301 iqrkflpsfl rgiaeenklv tspnfvvtqa lvalladkga klrpnydkse vekkgplela
     3361 nalaacclss rlssqhrqwa aqqlvrtlaa hdrdnqttlq tladmggdlr kcsfikleah
     3421 qnrvmtcvwc nkkgllatsg ndgtirvwnv tkkqyslqqt cvfnrlegda eeslgspsdp
     3481 sfspvswsis gkylagalek mvniwqvngg kglvdiqphw vsalawpeeg patawsgesp
     3541 elllvgrmdg slglievvdv stmhrreleh cyrkdvsvtc iawfsedrpf avgyfdgkll
     3601 lgtkeplekg givlidahkd tlismkwdpt ghilmtcake dsvklwgsis gcwcclhslc
     3661 hpsivngiaw crlpgkgskl qllmatgcqs glvcvwripq dttqtnvtsa egwweqesnc
     3721 qdgyrkssga kcvyqlrghi tpvrtvafss dglalvsggl gglmniwslr dgsvlqtvvi
     3781 gsgaiqttvw ipevgvaacs nrskdvlvvn ctaewaaanh vlatcrtalk qqgvlglnma
     3841 pcmraflerl pmmlqeqyay ekphvvcgdq lvhspymqcl aslavglhld qllcnppvpp
     3901 hhqnclpdpa swnpnewawl ecfsttikaa ealtngaqfp esftvpdlep vpedelvflm
     3961 dnskwingmd eqimswatsr pedwhlggkc dvylwgagrh gqlaeagrnv mvpaaapsfs
     4021 qaqqvicgqn ctfviqangt vlacgegsyg rlgqgnsddl hvltvisalq gfvvtqlvts
     4081 cgsdghsmal tesgevfswg dgdygklghg nsdrqrrprq iealqgeevv qmscgfkhsa
     4141 vvtsdgklft fgngdygrlg lgntsnkklp ervtalegyq igqvacglnh tlavsadgsm
     4201 vwafgdgdyg klglgnstak sspqkidvlc gigikkvacg tqfsvaltkd ghvytfgqdr
     4261 liglpegrar nhnrpqqipv lagviiedva vgaehtlala sngdvyawgs nsegqlglgh
     4321 tnhvreptlv tglqgknvrq isagrchsaa wtappvppra pgvsvplqlg lpdtvppqyg
     4381 alrevsihtv rarlrllyhf sdlmysswrl lnlspnnqns tshynagtwg ivqgqlrpll
     4441 aprvytlpmv rsigktmvqg knygpqitvk ristrgrkck pifvqiarqv vklnasdlrl
     4501 psrawkvklv gegaddaggv fddtitemcq eletgivdll ipspnataev gynrdrflfn
     4561 psacldehlm qfkflgilmg vairtkkpld lhlaplvwkq lccvpltled leevdllyvq
     4621 tlnsilhied sgiteesfhe mipldsfvgq sadgkmvpii pggnsipltf snrkeyvera
     4681 ieyrlhemdr qvaavregms wivpvpllsl ltakqleqmv cgmpeisvev lkkvvryrev
     4741 deqhqlvqwf whtleefsne ervlfmrfvs grsrlpanta disqrfqimk vdrpydslpt
     4801 sqtcffqlrl ppyssqlvma erlryainnc rsidmdnyml srnvdnaegs dtdy
//
LOCUS       XP_047289212            4853 aa            linear   PRI 05-AUG-2025
DEFINITION  putative E3 ubiquitin-protein ligase HERC1 isoform X30 [Homo
            sapiens].
ACCESSION   XP_047289212
VERSION     XP_047289212.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433256.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4853
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4853
                     /product="putative E3 ubiquitin-protein ligase HERC1
                     isoform X30"
                     /calculated_mol_wt=531073
     Region          374..703
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          683..733
                     /region_name="RCC1"
                     /note="Regulator of chromosome condensation (RCC1) repeat;
                     pfam00415"
                     /db_xref="CDD:395335"
     Region          2031..2188
                     /region_name="SPRY_HERC1"
                     /note="SPRY domain in HERC1; cd12881"
                     /db_xref="CDD:293939"
     Region          2752..2795
                     /region_name="UBA_HERC1"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC1 and similar proteins; cd14401"
                     /db_xref="CDD:270584"
     Region          <3379..3770
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          3424..3467
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3481..3516
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3521..3568
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3577..3612
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3621..3657
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3664..3695
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3742..3778
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3991..4327
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          4465..4833
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4470,4511,4522,4589,4767,4797..4798,4801..4805,4825,
                     4832)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4617,4620..4621,4623..4624,4627,4635,4637,
                     4641..4642,4644,4653,4658,4675,4679)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4853
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /coded_by="XM_047433256.1:154..14715"
                     /db_xref="GeneID:8925"
                     /db_xref="HGNC:HGNC:4867"
                     /db_xref="MIM:605109"
ORIGIN      
        1 matmippvkl kwlehlnssw itedsesiat regvavlysk lvsnkevvpl pqqvlclkgp
       61 qlpdferesl ssdeqdhyld allssqlala kmvcsdspfa galrkrllvl qrvfyalsnk
      121 yhdkgkvkqq qhspesssgs advhsvserp rsstdaliem gvrtglsllf allrqswmmp
      181 vsgpglslcn dvihtaievv sslpplslan eskippmgld clsqvttflk gvtipnsgad
      241 tlgrrlasel llglaaqrgs lryllewiem algasavvht mekgkllssq egmisfdcfm
      301 tilmqmrrsl gssadrsqwr eptrtsdglc slyeaalclf eevcrmasdy srtcaspdsi
      361 qtgdapivse tcevyvwgsn sshqlvegtq ekilqpklap sfsdaqtiea gqyctfvist
      421 dgsvracgkg sygrlglgds nnqstlkklt fephrsikkv ssskgsdght lafttegevf
      481 swgdgdygkl ghgnsstqky pkliqgplqg kvvvcvsagy rhsaavtedg elytwgegdf
      541 grlghgdsns rniptlvkdi snvgevscgs shtialskdg rtvwsfgggd ngklghgdtn
      601 rvykpkviea lqgmfirkvc agsqsslalt stgqvyawgc gaclgcgsse atalrpklie
      661 elaatrivdv sigdshclal shdnevyawg nnsmgqcgqg nstgpitkpk kvsgldgiai
      721 qqisagtshs lawtalprdr qvvawhrpyc vdleestfsh lrsflerycd kinseipplp
      781 fpssrehhsf lklclkllsn hlalalaggv atsilgrqag plrnllfrlm dstvpdeiqe
      841 vvietlsvga tmllpplrer mellhsllpq gpdrweslsk gqrmqldiil tslqdhthva
      901 sllgysspsd aadlssvctg ygnlsdqpyg tqschpdthl aeilmktllr nlgfytdqaf
      961 geleknsdkf llgtsssens qpahlhellc slqkqllafc hinnisenss svallhkhlq
     1021 lllphatdiy srsanllkes pwngsvgekl rdviyvsaag smlcqivnsl lllpvsvarp
     1081 llsylldllp pldclnrllp aadlledqel qwplhggpel idpaglplpq paqswvwlvd
     1141 lertiallig rclggmlqgs pvspeeqdta ywmktplfsd gvemdtpqld kcmsclleva
     1201 lsgneeqkpf dyklrpeiav yvdlalgcsk eparslwism qdyavskdwd satlsnesll
     1261 dtvsrfvlaa llkhtnllsq acgesryqpg khlsevyrcv ykvrsrllac knleliqtrs
     1321 ssrdrwisen qdsadvdpqe hsftrtidee aemeeqaerd reeghpeped eeeerehevm
     1381 tagkifqcfl sarevarsrd rdrmnsgags garaddpppq sqqerrvstd lpegqdvyta
     1441 acnsvihrca llilgvspvi delqkrreeg qlqqpstsas eggglmtrse sltaesrlvh
     1501 tspnyrliks rsesdlsqpe sdeegyalsg rrnvdldlaa shrkrgpmhs qleslsdswa
     1561 rlkhsrdwlc nssysfesdf dltkslgvht lienvvsfvs gdvgnapgfk epeesmstsp
     1621 qasiiameqq qlraelrlea lhqilvllsg meekgsisla gsrlssgfqs stlltsvrlq
     1681 flagcfglgt vghtggkges grlhhyqdgi raakrniqie iqvavhkiyq qlsatleral
     1741 qankhhieaq qrlllvtvfa lsvhyqpvdv slaistglln vlsqlcgtdt mlgqplqllp
     1801 ktgvsqlsta lkvastrllq ilaittgtya dklspkvvqs lldllcsqlk nllsqtgvlh
     1861 masfgegeqe dgeeeekkvd ssgetekkdf raalrkqhaa elhlgdflvf lrrvvsskai
     1921 qskmaspkwt evllniasqk cssgiplvgn lrtrllalhv leavlpaces gveddqmaqi
     1981 verlfsllsd cmwetpiaqa khaiqikeke qeiklqqgel eeedenlpiq evsfdpekaq
     2041 cclvengqil thgsggkgyg lastgvtsgc yqwkfyivke nrgnegtcvg vsrwpvhdfn
     2101 hrttsdmwly raysgnlyhn geqtltlssf tqgdfitcvl dmeartisfg kngeepklaf
     2161 edvdaaelyp cvmfyssnpg ekvkicdmqm rgtprdllpg dpicspvaav laeatiqlir
     2221 ilhrtdrwty cinkkmmerl hkikicikes gqklkksrsv qsreenemre ekeskeeekg
     2281 khtrhgladl selqlrtlci evwpvlavig gvdaglrvgg rcvhkqtgrh atllgvvkeg
     2341 stsakvqwde aeitisfptf wspsdtplyn lepceplpfd varfrgltas vlldltyltg
     2401 vhedmgkqst krhekkhrhe seekgdveqk pesesaldmr tgltsddvks qsttssksen
     2461 eiasfsldpt lpsvesqhqi tegkrknheh msknhdvaqs eiravqlsyl ylgamkslsa
     2521 llgcskyael llipkvlaen ghnsdcassp vvhedvemra alqflmrhmv kravmrspik
     2581 ralgladler aqamiyklvv hglledqfgg kikqeidqqa eesdpaqqaq tpvttspsas
     2641 sttsfmsssl edtttattpv tdtetvpase spgvmplsll rqmfssyptt tvlptrraqt
     2701 ppisslptsp sdevgrrqsl tspdsqsarp anrtalsdps srlstspppp aiavpllemg
     2761 fslrqiakam eatgargead aqnitvlamw miehpghede eepqsgstad srpgaavlgs
     2821 ggksndpcyl qspgdipsad aaemeegfse spdnldhten aasgsgpsar grsavtrrhk
     2881 fdlaartlla raaglyrsvq ahrnqsrreg islqqdpgal ydfnldeele idlddeamea
     2941 mfgqdltsdn dilgmwipeh vcesedreev vvcelcecsv vsfnqhmkrn hpgcgrsanr
     3001 qgyrsngsyv dgwfggecgs gnpyyllcgt crekylamkt kskstssery kgqapdligk
     3061 qdsvyeedwd mldvdedekl tgeeefella gplglndrri vpepvqfpds dplgasvamv
     3121 tatnsmeetl mqigchgsve ksssgritlg eqaaalanph drvvalrrvt aaaqvllart
     3181 mvmralslls vsgsscslaa gleslgltdi rtlvrlmcla aagraglsts psamastser
     3241 srgghskank pisclaylst avgclasnap saakllvqlc tqnlisaatg vnlttvddsi
     3301 qrkflpsflr giaeenklvt spnfvvtqal valladkgak lrpnydksev ekkgplelan
     3361 alaacclssr lssqhrqwaa qqlvrtlaah drdnqttlqt ladmggdlrk csfikleahq
     3421 nrvmtcvwcn kkgllatsgn dgtirvwnvt kkqyslqqtc vfnrlegdae eslgspsdps
     3481 fspvswsisg kylagalekm vniwqvnggk glvdiqphwv salawpeegp atawsgespe
     3541 lllvgrmdgs lglievvdvs tmhrrelehc yrkdvsvtci awfsedrpfa vgyfdgklll
     3601 gtkeplekgg ivlidahkdt lismkwdptg hilmtcaked svklwgsisg cwcclhslch
     3661 psivngiawc rlpgkgsklq llmatgcqsg lvcvwripqd ttqtnvtsae gwweqesncq
     3721 dgyrkssgak cvyqlrghit pvrtvafssd glalvsgglg glmniwslrd gsvlqtvvig
     3781 sgaiqttvwi pevgvaacsn rskdvlvvnc taewaaanhv latcrtalkq qgvlglnmap
     3841 cmraflerlp mmlqeqyaye kphvvcgdql vhspymqcla slavglhldq llcnppvpph
     3901 hqnclpdpas wnpnewawle cfsttikaae altngaqfpe sftvpdlepv pedelvflmd
     3961 nskwingmde qimswatsrp edwhlggkcd vylwgagrhg qlaeagrnvm vpaaapsfsq
     4021 aqqvicgqnc tfviqangtv lacgegsygr lgqgnsddlh vltvisalqg fvvtqlvtsc
     4081 gsdghsmalt esgevfswgd gdygklghgn sdrqrrprqi ealqgeevvq mscgfkhsav
     4141 vtsdgklftf gngdygrlgl gntsnkklpe rvtalegyqi gqvacglnht lavsadgsmv
     4201 wafgdgdygk lglgnstaks spqkidvlcg igikkvacgt qfsvaltkdg hvytfgqdrl
     4261 iglpegrarn hnrpqqipvl agviiedvav gaehtlalas ngdvyawgsn segqlglght
     4321 nhvreptlvt glqgknvrqi sagrchsaaw tappvpprap gvsvplqlgl pdtvppqyga
     4381 lrevsihtvr arlrllyhfs dlmysswrll nlspnnqnst shynagtwgi vqgqlrplla
     4441 prvytlpmvr sigktmvqgk nygpqitvkr istrgrkckp ifvqiarqvv klnasdlrlp
     4501 srawkvklvg egaddaggvf ddtitemcqe letgivdlli pspnataevg ynrdrflfnp
     4561 sacldehlmq fkflgilmgv airtkkpldl hlaplvwkql ccvpltledl eevdllyvqt
     4621 lnsilhieds giteesfhem ipldsfvgqs adgkmvpiip ggnsipltfs nrkeyverai
     4681 eyrlhemdrq vaavregmsw ivpvpllsll takqleqmvc gmpeisvevl kkvvryrevd
     4741 eqhqlvqwfw htleefsnee rvlfmrfvsg rsrlpantad isqrfqimkv drpydslpts
     4801 qtcffqlrlp pyssqlvmae rlryainncr sidmdnymls rnvdnaegsd tdy
//
LOCUS       XP_047289213            4853 aa            linear   PRI 05-AUG-2025
DEFINITION  putative E3 ubiquitin-protein ligase HERC1 isoform X31 [Homo
            sapiens].
ACCESSION   XP_047289213
VERSION     XP_047289213.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433257.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4853
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4853
                     /product="putative E3 ubiquitin-protein ligase HERC1
                     isoform X31"
                     /calculated_mol_wt=531150
     Region          374..703
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          683..733
                     /region_name="RCC1"
                     /note="Regulator of chromosome condensation (RCC1) repeat;
                     pfam00415"
                     /db_xref="CDD:395335"
     Region          2032..2189
                     /region_name="SPRY_HERC1"
                     /note="SPRY domain in HERC1; cd12881"
                     /db_xref="CDD:293939"
     Region          2745..2788
                     /region_name="UBA_HERC1"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC1 and similar proteins; cd14401"
                     /db_xref="CDD:270584"
     Region          <3379..3770
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          3424..3467
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3481..3516
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3521..3568
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3577..3612
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3621..3657
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3664..3695
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3742..3778
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3991..4327
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          4465..4833
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4470,4511,4522,4589,4767,4797..4798,4801..4805,4825,
                     4832)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4617,4620..4621,4623..4624,4627,4635,4637,
                     4641..4642,4644,4653,4658,4675,4679)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4853
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /coded_by="XM_047433257.1:149..14710"
                     /db_xref="GeneID:8925"
                     /db_xref="HGNC:HGNC:4867"
                     /db_xref="MIM:605109"
ORIGIN      
        1 matmippvkl kwlehlnssw itedsesiat regvavlysk lvsnkevvpl pqqvlclkgp
       61 qlpdferesl ssdeqdhyld allssqlala kmvcsdspfa galrkrllvl qrvfyalsnk
      121 yhdkgkvkqq qhspesssgs advhsvserp rsstdaliem gvrtglsllf allrqswmmp
      181 vsgpglslcn dvihtaievv sslpplslan eskippmgld clsqvttflk gvtipnsgad
      241 tlgrrlasel llglaaqrgs lryllewiem algasavvht mekgkllssq egmisfdcfm
      301 tilmqmrrsl gssadrsqwr eptrtsdglc slyeaalclf eevcrmasdy srtcaspdsi
      361 qtgdapivse tcevyvwgsn sshqlvegtq ekilqpklap sfsdaqtiea gqyctfvist
      421 dgsvracgkg sygrlglgds nnqstlkklt fephrsikkv ssskgsdght lafttegevf
      481 swgdgdygkl ghgnsstqky pkliqgplqg kvvvcvsagy rhsaavtedg elytwgegdf
      541 grlghgdsns rniptlvkdi snvgevscgs shtialskdg rtvwsfgggd ngklghgdtn
      601 rvykpkviea lqgmfirkvc agsqsslalt stgqvyawgc gaclgcgsse atalrpklie
      661 elaatrivdv sigdshclal shdnevyawg nnsmgqcgqg nstgpitkpk kvsgldgiai
      721 qqisagtshs lawtalprdr qvvawhrpyc vdleestfsh lrsflerycd kinseipplp
      781 fpssrehhsf lklclkllsn hlalalaggv atsilgrqag plrnllfrlm dstvpdeiqe
      841 vvietlsvga tmllpplrer mellhsllpq gpdrweslsk gqrmqldiil tslqdhthva
      901 sllgysspsd aadlssvctg ygnlsdqpyg tqschpdthl aeilmktllr nlgfytdqaf
      961 geleknsdkf llgtsssens qpahlhellc slqkqllafc hinnisenss svallhkhlq
     1021 lllphatdiy srsanllkes pwngsvgekl rdviyvsaag smlcqivnsl lllpvsvarp
     1081 llsylldllp pldclnrllp aadlledqel qwplhggpel idpaglplpq paqswvwlvd
     1141 lertiallig rclggmlqgs pvspeeqdta ywmktplfsd gvemdtpqld kcmsclleva
     1201 lsgneeqkpf dyklrpeiav yvdlalgcsk eparslwism qdyavskdwd satlsnesll
     1261 dtvsrfvlaa llkhtnllsq acgesryqpg khlsevyrcv ykvrsrllac knleliqtrs
     1321 ssrdrwisen qdsadvdpqe hsftrtidee aemeeqaerd reeghpeped eeeerehevm
     1381 tagkifqcfl sarevarsrd rdrmnsgags garaddpppq sqqerrvstd lpegqdvyta
     1441 acnsvihrca llilgvspvi delqkrreeg qlqqpstsas eggglmtrse sltaesrlvh
     1501 tspnyrliks rsesdlsqpe sdeegyalsg rrnvdldlaa shrkrgpmhs qleslsdswa
     1561 rlkhsrdwlc nssysfesdf dltkslgvht lienvvsfvs gdvgnapgfk epeesmstsp
     1621 qasiiameqq qlraelrlea lhqilvllsg meekgsisla gsrlssgfqs stlltsvrlq
     1681 flagcfglgt vghtggkges grlhhyqdgi raakrniqie iqvavhkiyq qlsatleral
     1741 qankhhieaq qrlllvtvfa lsvhyqpvdv slaistglln vlsqlcgtdt mlgqplqllp
     1801 ktgvsqlsta lkvastrllq ilaittgtya dklspkvvqs lldllcsqlk nllsqtgvlh
     1861 masfgegeqe dgeeeekkvd ssgetekkdf raalrkqhaa elhlgdflvf lrrvvsskai
     1921 qskmaspkwt evllniasqk cssgiplvgn lrtrllalhv leavlpaces gveddqmaqi
     1981 verlfsllsd cmwetpiaqa khaiqikeke qeiklqkqge leeedenlpi qevsfdpeka
     2041 qcclvengqi lthgsggkgy glastgvtsg cyqwkfyivk enrgnegtcv gvsrwpvhdf
     2101 nhrttsdmwl yraysgnlyh ngeqtltlss ftqgdfitcv ldmeartisf gkngeepkla
     2161 fedvdaaely pcvmfyssnp gekvkicdmq mrgtprdllp gdpicspvaa vlaeatiqli
     2221 rilhrtdrwt ycinkkmmer lhkikicike sgqklkksrs vqsreenemr eekeskeeek
     2281 gkhtrhglad lselqlrtlc ievwpvlavi ggvdaglrvg grcvhkqtgr hatllgvvke
     2341 gstsakvqwd eaeitisdtp lynlepcepl pfdvarfrgl tasvlldlty ltgvhedmgk
     2401 qstkrhekkh rheseekgdv eqkpesesal dmrtgltsdd vksqsttssk seneiasfsl
     2461 dptlpsvesq hqitegkrkn hehmsknhdv aqseiravql sylylgamks lsallgcsky
     2521 aelllipkvl aenghnsdca sspvvhedve mraalqflmr hmvkravmrs pikralglad
     2581 leraqamiyk lvvhglledq fggkikqeid qqaeesdpaq qaqtpvttsp sassttsfms
     2641 ssledtttat tpvtdtetvp asespgvmpl sllrqmfssy ptttvlptrr aqtppisslp
     2701 tspsdevgrr qsltspdsqs arpanrtals dpssrlstsp pppaiavpll emgfslrqia
     2761 kameatgarg eadaqnitvl amwmiehpgh edeeepqsgs tadsrpgaav lgsggksndp
     2821 cylqspgdip sadaaemeeg fsespdnldh tenaasgsgp sargrsavtr rhkfdlaart
     2881 llaraaglyr svqahrnqsr regislqqdp galydfnlde eleidlddea meamfgqdlt
     2941 sdndilgmwi pevldwptwh vcesedreev vvcelcecsv vsfnqhmkrn hpgcgrsanr
     3001 qgyrsngsyv dgwfggecgs gnpyyllcgt crekylamkt kskstssery kgqapdligk
     3061 qdsvyeedwd mldvdedekl tgeeefella gplglndrri vpepvqfpds dplgasvamv
     3121 tatnsmeetl mqigchgsve ksssgritlg eqaaalanph drvvalrrvt aaaqvllart
     3181 mvmralslls vsgsscslaa gleslgltdi rtlvrlmcla aagraglsts psamastser
     3241 srgghskank pisclaylst avgclasnap saakllvqlc tqnlisaatg vnlttvddsi
     3301 qrkflpsflr giaeenklvt spnfvvtqal valladkgak lrpnydksev ekkgplelan
     3361 alaacclssr lssqhrqwaa qqlvrtlaah drdnqttlqt ladmggdlrk csfikleahq
     3421 nrvmtcvwcn kkgllatsgn dgtirvwnvt kkqyslqqtc vfnrlegdae eslgspsdps
     3481 fspvswsisg kylagalekm vniwqvnggk glvdiqphwv salawpeegp atawsgespe
     3541 lllvgrmdgs lglievvdvs tmhrrelehc yrkdvsvtci awfsedrpfa vgyfdgklll
     3601 gtkeplekgg ivlidahkdt lismkwdptg hilmtcaked svklwgsisg cwcclhslch
     3661 psivngiawc rlpgkgsklq llmatgcqsg lvcvwripqd ttqtnvtsae gwweqesncq
     3721 dgyrkssgak cvyqlrghit pvrtvafssd glalvsgglg glmniwslrd gsvlqtvvig
     3781 sgaiqttvwi pevgvaacsn rskdvlvvnc taewaaanhv latcrtalkq qgvlglnmap
     3841 cmraflerlp mmlqeqyaye kphvvcgdql vhspymqcla slavglhldq llcnppvpph
     3901 hqnclpdpas wnpnewawle cfsttikaae altngaqfpe sftvpdlepv pedelvflmd
     3961 nskwingmde qimswatsrp edwhlggkcd vylwgagrhg qlaeagrnvm vpaaapsfsq
     4021 aqqvicgqnc tfviqangtv lacgegsygr lgqgnsddlh vltvisalqg fvvtqlvtsc
     4081 gsdghsmalt esgevfswgd gdygklghgn sdrqrrprqi ealqgeevvq mscgfkhsav
     4141 vtsdgklftf gngdygrlgl gntsnkklpe rvtalegyqi gqvacglnht lavsadgsmv
     4201 wafgdgdygk lglgnstaks spqkidvlcg igikkvacgt qfsvaltkdg hvytfgqdrl
     4261 iglpegrarn hnrpqqipvl agviiedvav gaehtlalas ngdvyawgsn segqlglght
     4321 nhvreptlvt glqgknvrqi sagrchsaaw tappvpprap gvsvplqlgl pdtvppqyga
     4381 lrevsihtvr arlrllyhfs dlmysswrll nlspnnqnst shynagtwgi vqgqlrplla
     4441 prvytlpmvr sigktmvqgk nygpqitvkr istrgrkckp ifvqiarqvv klnasdlrlp
     4501 srawkvklvg egaddaggvf ddtitemcqe letgivdlli pspnataevg ynrdrflfnp
     4561 sacldehlmq fkflgilmgv airtkkpldl hlaplvwkql ccvpltledl eevdllyvqt
     4621 lnsilhieds giteesfhem ipldsfvgqs adgkmvpiip ggnsipltfs nrkeyverai
     4681 eyrlhemdrq vaavregmsw ivpvpllsll takqleqmvc gmpeisvevl kkvvryrevd
     4741 eqhqlvqwfw htleefsnee rvlfmrfvsg rsrlpantad isqrfqimkv drpydslpts
     4801 qtcffqlrlp pyssqlvmae rlryainncr sidmdnymls rnvdnaegsd tdy
//
LOCUS       XP_047289214            4852 aa            linear   PRI 05-AUG-2025
DEFINITION  putative E3 ubiquitin-protein ligase HERC1 isoform X32 [Homo
            sapiens].
ACCESSION   XP_047289214
VERSION     XP_047289214.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433258.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4852
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4852
                     /product="putative E3 ubiquitin-protein ligase HERC1
                     isoform X32"
                     /calculated_mol_wt=531020
     Region          374..703
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          683..733
                     /region_name="RCC1"
                     /note="Regulator of chromosome condensation (RCC1) repeat;
                     pfam00415"
                     /db_xref="CDD:395335"
     Region          2032..2189
                     /region_name="SPRY_HERC1"
                     /note="SPRY domain in HERC1; cd12881"
                     /db_xref="CDD:293939"
     Region          2745..2788
                     /region_name="UBA_HERC1"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC1 and similar proteins; cd14401"
                     /db_xref="CDD:270584"
     Region          <3378..3769
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          3423..3466
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3480..3515
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3520..3567
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3576..3611
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3620..3656
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3663..3694
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3741..3777
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3990..4326
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          4464..4832
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4469,4510,4521,4588,4766,4796..4797,4800..4804,4824,
                     4831)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4616,4619..4620,4622..4623,4626,4634,4636,
                     4640..4641,4643,4652,4657,4674,4678)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4852
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /coded_by="XM_047433258.1:149..14707"
                     /db_xref="GeneID:8925"
                     /db_xref="HGNC:HGNC:4867"
                     /db_xref="MIM:605109"
ORIGIN      
        1 matmippvkl kwlehlnssw itedsesiat regvavlysk lvsnkevvpl pqqvlclkgp
       61 qlpdferesl ssdeqdhyld allssqlala kmvcsdspfa galrkrllvl qrvfyalsnk
      121 yhdkgkvkqq qhspesssgs advhsvserp rsstdaliem gvrtglsllf allrqswmmp
      181 vsgpglslcn dvihtaievv sslpplslan eskippmgld clsqvttflk gvtipnsgad
      241 tlgrrlasel llglaaqrgs lryllewiem algasavvht mekgkllssq egmisfdcfm
      301 tilmqmrrsl gssadrsqwr eptrtsdglc slyeaalclf eevcrmasdy srtcaspdsi
      361 qtgdapivse tcevyvwgsn sshqlvegtq ekilqpklap sfsdaqtiea gqyctfvist
      421 dgsvracgkg sygrlglgds nnqstlkklt fephrsikkv ssskgsdght lafttegevf
      481 swgdgdygkl ghgnsstqky pkliqgplqg kvvvcvsagy rhsaavtedg elytwgegdf
      541 grlghgdsns rniptlvkdi snvgevscgs shtialskdg rtvwsfgggd ngklghgdtn
      601 rvykpkviea lqgmfirkvc agsqsslalt stgqvyawgc gaclgcgsse atalrpklie
      661 elaatrivdv sigdshclal shdnevyawg nnsmgqcgqg nstgpitkpk kvsgldgiai
      721 qqisagtshs lawtalprdr qvvawhrpyc vdleestfsh lrsflerycd kinseipplp
      781 fpssrehhsf lklclkllsn hlalalaggv atsilgrqag plrnllfrlm dstvpdeiqe
      841 vvietlsvga tmllpplrer mellhsllpq gpdrweslsk gqrmqldiil tslqdhthva
      901 sllgysspsd aadlssvctg ygnlsdqpyg tqschpdthl aeilmktllr nlgfytdqaf
      961 geleknsdkf llgtsssens qpahlhellc slqkqllafc hinnisenss svallhkhlq
     1021 lllphatdiy srsanllkes pwngsvgekl rdviyvsaag smlcqivnsl lllpvsvarp
     1081 llsylldllp pldclnrllp aadlledqel qwplhggpel idpaglplpq paqswvwlvd
     1141 lertiallig rclggmlqgs pvspeeqdta ywmktplfsd gvemdtpqld kcmsclleva
     1201 lsgneeqkpf dyklrpeiav yvdlalgcsk eparslwism qdyavskdwd satlsnesll
     1261 dtvsrfvlaa llkhtnllsq acgesryqpg khlsevyrcv ykvrsrllac knleliqtrs
     1321 ssrdrwisen qdsadvdpqe hsftrtidee aemeeqaerd reeghpeped eeeerehevm
     1381 tagkifqcfl sarevarsrd rdrmnsgags garaddpppq sqqerrvstd lpegqdvyta
     1441 acnsvihrca llilgvspvi delqkrreeg qlqqpstsas eggglmtrse sltaesrlvh
     1501 tspnyrliks rsesdlsqpe sdeegyalsg rrnvdldlaa shrkrgpmhs qleslsdswa
     1561 rlkhsrdwlc nssysfesdf dltkslgvht lienvvsfvs gdvgnapgfk epeesmstsp
     1621 qasiiameqq qlraelrlea lhqilvllsg meekgsisla gsrlssgfqs stlltsvrlq
     1681 flagcfglgt vghtggkges grlhhyqdgi raakrniqie iqvavhkiyq qlsatleral
     1741 qankhhieaq qrlllvtvfa lsvhyqpvdv slaistglln vlsqlcgtdt mlgqplqllp
     1801 ktgvsqlsta lkvastrllq ilaittgtya dklspkvvqs lldllcsqlk nllsqtgvlh
     1861 masfgegeqe dgeeeekkvd ssgetekkdf raalrkqhaa elhlgdflvf lrrvvsskai
     1921 qskmaspkwt evllniasqk cssgiplvgn lrtrllalhv leavlpaces gveddqmaqi
     1981 verlfsllsd cmwetpiaqa khaiqikeke qeiklqkqge leeedenlpi qevsfdpeka
     2041 qcclvengqi lthgsggkgy glastgvtsg cyqwkfyivk enrgnegtcv gvsrwpvhdf
     2101 nhrttsdmwl yraysgnlyh ngeqtltlss ftqgdfitcv ldmeartisf gkngeepkla
     2161 fedvdaaely pcvmfyssnp gekvkicdmq mrgtprdllp gdpicspvaa vlaeatiqli
     2221 rilhrtdrwt ycinkkmmer lhkikicike sgqklkksrs vqsreenemr eekeskeeek
     2281 gkhtrhglad lselqlrtlc ievwpvlavi ggvdaglrvg grcvhkqtgr hatllgvvke
     2341 gstsakvqwd eaeitisdtp lynlepcepl pfdvarfrgl tasvlldlty ltgvhedmgk
     2401 qstkrhekkh rheseekgdv eqkpesesal dmrtgltsdd vksqsttssk seneiasfsl
     2461 dptlpsvesq hqitegkrkn hehmsknhdv aqseiravql sylylgamks lsallgcsky
     2521 aelllipkvl aenghnsdca sspvvhedve mraalqflmr hmvkravmrs pikralglad
     2581 leraqamiyk lvvhglledq fggkikqeid qqaeesdpaq qaqtpvttsp sassttsfms
     2641 ssledtttat tpvtdtetvp asespgvmpl sllrqmfssy ptttvlptrr aqtppisslp
     2701 tspsdevgrr qsltspdsqs arpanrtals dpssrlstsp pppaiavpll emgfslrqia
     2761 kameatgarg eadaqnitvl amwmiehpgh edeeepqsgs tadsrpgaav lgsggksndp
     2821 cylqspgdip sadaaemeeg fsespdnldh tenaasgsgp sargrsavtr rhkfdlaart
     2881 llaraaglyr svqahrnqsr regislqqdp galydfnlde eleidlddea meamfgqdlt
     2941 sdndilgmwi pevldwptwh vcesedreev vvcelcecsv vsfnqhmkrn hpgcgrsanr
     3001 qgyrsngsyv dgwfggecgs gnpyyllcgt crekylamkt kskstssery kgqapdligk
     3061 qdsvyedwdm ldvdedeklt geeefellag plglndrriv pepvqfpdsd plgasvamvt
     3121 atnsmeetlm qigchgsvek sssgritlge qaaalanphd rvvalrrvta aaqvllartm
     3181 vmralsllsv sgsscslaag leslgltdir tlvrlmclaa agraglstsp samastsers
     3241 rgghskankp isclaylsta vgclasnaps aakllvqlct qnlisaatgv nlttvddsiq
     3301 rkflpsflrg iaeenklvts pnfvvtqalv alladkgakl rpnydkseve kkgplelana
     3361 laacclssrl ssqhrqwaaq qlvrtlaahd rdnqttlqtl admggdlrkc sfikleahqn
     3421 rvmtcvwcnk kgllatsgnd gtirvwnvtk kqyslqqtcv fnrlegdaee slgspsdpsf
     3481 spvswsisgk ylagalekmv niwqvnggkg lvdiqphwvs alawpeegpa tawsgespel
     3541 llvgrmdgsl glievvdvst mhrrelehcy rkdvsvtcia wfsedrpfav gyfdgklllg
     3601 tkeplekggi vlidahkdtl ismkwdptgh ilmtcakeds vklwgsisgc wcclhslchp
     3661 sivngiawcr lpgkgsklql lmatgcqsgl vcvwripqdt tqtnvtsaeg wweqesncqd
     3721 gyrkssgakc vyqlrghitp vrtvafssdg lalvsgglgg lmniwslrdg svlqtvvigs
     3781 gaiqttvwip evgvaacsnr skdvlvvnct aewaaanhvl atcrtalkqq gvlglnmapc
     3841 mraflerlpm mlqeqyayek phvvcgdqlv hspymqclas lavglhldql lcnppvpphh
     3901 qnclpdpasw npnewawlec fsttikaaea ltngaqfpes ftvpdlepvp edelvflmdn
     3961 skwingmdeq imswatsrpe dwhlggkcdv ylwgagrhgq laeagrnvmv paaapsfsqa
     4021 qqvicgqnct fviqangtvl acgegsygrl gqgnsddlhv ltvisalqgf vvtqlvtscg
     4081 sdghsmalte sgevfswgdg dygklghgns drqrrprqie alqgeevvqm scgfkhsavv
     4141 tsdgklftfg ngdygrlglg ntsnkklper vtalegyqig qvacglnhtl avsadgsmvw
     4201 afgdgdygkl glgnstakss pqkidvlcgi gikkvacgtq fsvaltkdgh vytfgqdrli
     4261 glpegrarnh nrpqqipvla gviiedvavg aehtlalasn gdvyawgsns egqlglghtn
     4321 hvreptlvtg lqgknvrqis agrchsaawt appvpprapg vsvplqlglp dtvppqygal
     4381 revsihtvra rlrllyhfsd lmysswrlln lspnnqnsts hynagtwgiv qgqlrpllap
     4441 rvytlpmvrs igktmvqgkn ygpqitvkri strgrkckpi fvqiarqvvk lnasdlrlps
     4501 rawkvklvge gaddaggvfd dtitemcqel etgivdllip spnataevgy nrdrflfnps
     4561 acldehlmqf kflgilmgva irtkkpldlh laplvwkqlc cvpltledle evdllyvqtl
     4621 nsilhiedsg iteesfhemi pldsfvgqsa dgkmvpiipg gnsipltfsn rkeyveraie
     4681 yrlhemdrqv aavregmswi vpvpllsllt akqleqmvcg mpeisvevlk kvvryrevde
     4741 qhqlvqwfwh tleefsneer vlfmrfvsgr srlpantadi sqrfqimkvd rpydslptsq
     4801 tcffqlrlpp yssqlvmaer lryainncrs idmdnymlsr nvdnaegsdt dy
//
LOCUS       XP_047289215            4846 aa            linear   PRI 05-AUG-2025
DEFINITION  putative E3 ubiquitin-protein ligase HERC1 isoform X33 [Homo
            sapiens].
ACCESSION   XP_047289215
VERSION     XP_047289215.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433259.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4846
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4846
                     /product="putative E3 ubiquitin-protein ligase HERC1
                     isoform X33"
                     /calculated_mol_wt=530252
     Region          374..703
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          683..733
                     /region_name="RCC1"
                     /note="Regulator of chromosome condensation (RCC1) repeat;
                     pfam00415"
                     /db_xref="CDD:395335"
     Region          2032..2189
                     /region_name="SPRY_HERC1"
                     /note="SPRY domain in HERC1; cd12881"
                     /db_xref="CDD:293939"
     Region          2745..2788
                     /region_name="UBA_HERC1"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC1 and similar proteins; cd14401"
                     /db_xref="CDD:270584"
     Region          <3372..3763
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          3417..3460
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3474..3509
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3514..3561
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3570..3605
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3614..3650
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3657..3688
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3735..3771
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3984..4320
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          4458..4826
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4463,4504,4515,4582,4760,4790..4791,4794..4798,4818,
                     4825)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4610,4613..4614,4616..4617,4620,4628,4630,
                     4634..4635,4637,4646,4651,4668,4672)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4846
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /coded_by="XM_047433259.1:154..14694"
                     /db_xref="GeneID:8925"
                     /db_xref="HGNC:HGNC:4867"
                     /db_xref="MIM:605109"
ORIGIN      
        1 matmippvkl kwlehlnssw itedsesiat regvavlysk lvsnkevvpl pqqvlclkgp
       61 qlpdferesl ssdeqdhyld allssqlala kmvcsdspfa galrkrllvl qrvfyalsnk
      121 yhdkgkvkqq qhspesssgs advhsvserp rsstdaliem gvrtglsllf allrqswmmp
      181 vsgpglslcn dvihtaievv sslpplslan eskippmgld clsqvttflk gvtipnsgad
      241 tlgrrlasel llglaaqrgs lryllewiem algasavvht mekgkllssq egmisfdcfm
      301 tilmqmrrsl gssadrsqwr eptrtsdglc slyeaalclf eevcrmasdy srtcaspdsi
      361 qtgdapivse tcevyvwgsn sshqlvegtq ekilqpklap sfsdaqtiea gqyctfvist
      421 dgsvracgkg sygrlglgds nnqstlkklt fephrsikkv ssskgsdght lafttegevf
      481 swgdgdygkl ghgnsstqky pkliqgplqg kvvvcvsagy rhsaavtedg elytwgegdf
      541 grlghgdsns rniptlvkdi snvgevscgs shtialskdg rtvwsfgggd ngklghgdtn
      601 rvykpkviea lqgmfirkvc agsqsslalt stgqvyawgc gaclgcgsse atalrpklie
      661 elaatrivdv sigdshclal shdnevyawg nnsmgqcgqg nstgpitkpk kvsgldgiai
      721 qqisagtshs lawtalprdr qvvawhrpyc vdleestfsh lrsflerycd kinseipplp
      781 fpssrehhsf lklclkllsn hlalalaggv atsilgrqag plrnllfrlm dstvpdeiqe
      841 vvietlsvga tmllpplrer mellhsllpq gpdrweslsk gqrmqldiil tslqdhthva
      901 sllgysspsd aadlssvctg ygnlsdqpyg tqschpdthl aeilmktllr nlgfytdqaf
      961 geleknsdkf llgtsssens qpahlhellc slqkqllafc hinnisenss svallhkhlq
     1021 lllphatdiy srsanllkes pwngsvgekl rdviyvsaag smlcqivnsl lllpvsvarp
     1081 llsylldllp pldclnrllp aadlledqel qwplhggpel idpaglplpq paqswvwlvd
     1141 lertiallig rclggmlqgs pvspeeqdta ywmktplfsd gvemdtpqld kcmsclleva
     1201 lsgneeqkpf dyklrpeiav yvdlalgcsk eparslwism qdyavskdwd satlsnesll
     1261 dtvsrfvlaa llkhtnllsq acgesryqpg khlsevyrcv ykvrsrllac knleliqtrs
     1321 ssrdrwisen qdsadvdpqe hsftrtidee aemeeqaerd reeghpeped eeeerehevm
     1381 tagkifqcfl sarevarsrd rdrmnsgags garaddpppq sqqerrvstd lpegqdvyta
     1441 acnsvihrca llilgvspvi delqkrreeg qlqqpstsas eggglmtrse sltaesrlvh
     1501 tspnyrliks rsesdlsqpe sdeegyalsg rrnvdldlaa shrkrgpmhs qleslsdswa
     1561 rlkhsrdwlc nssysfesdf dltkslgvht lienvvsfvs gdvgnapgfk epeesmstsp
     1621 qasiiameqq qlraelrlea lhqilvllsg meekgsisla gsrlssgfqs stlltsvrlq
     1681 flagcfglgt vghtggkges grlhhyqdgi raakrniqie iqvavhkiyq qlsatleral
     1741 qankhhieaq qrlllvtvfa lsvhyqpvdv slaistglln vlsqlcgtdt mlgqplqllp
     1801 ktgvsqlsta lkvastrllq ilaittgtya dklspkvvqs lldllcsqlk nllsqtgvlh
     1861 masfgegeqe dgeeeekkvd ssgetekkdf raalrkqhaa elhlgdflvf lrrvvsskai
     1921 qskmaspkwt evllniasqk cssgiplvgn lrtrllalhv leavlpaces gveddqmaqi
     1981 verlfsllsd cmwetpiaqa khaiqikeke qeiklqkqge leeedenlpi qevsfdpeka
     2041 qcclvengqi lthgsggkgy glastgvtsg cyqwkfyivk enrgnegtcv gvsrwpvhdf
     2101 nhrttsdmwl yraysgnlyh ngeqtltlss ftqgdfitcv ldmeartisf gkngeepkla
     2161 fedvdaaely pcvmfyssnp gekvkicdmq mrgtprdllp gdpicspvaa vlaeatiqli
     2221 rilhrtdrwt ycinkkmmer lhkikicike sgqklkksrs vqsreenemr eekeskeeek
     2281 gkhtrhglad lselqlrtlc ievwpvlavi ggvdaglrvg grcvhkqtgr hatllgvvke
     2341 gstsakvqwd eaeitisdtp lynlepcepl pfdvarfrgl tasvlldlty ltgvhedmgk
     2401 qstkrhekkh rheseekgdv eqkpesesal dmrtgltsdd vksqsttssk seneiasfsl
     2461 dptlpsvesq hqitegkrkn hehmsknhdv aqseiravql sylylgamks lsallgcsky
     2521 aelllipkvl aenghnsdca sspvvhedve mraalqflmr hmvkravmrs pikralglad
     2581 leraqamiyk lvvhglledq fggkikqeid qqaeesdpaq qaqtpvttsp sassttsfms
     2641 ssledtttat tpvtdtetvp asespgvmpl sllrqmfssy ptttvlptrr aqtppisslp
     2701 tspsdevgrr qsltspdsqs arpanrtals dpssrlstsp pppaiavpll emgfslrqia
     2761 kameatgarg eadaqnitvl amwmiehpgh edeeepqsgs tadsrpgaav lgsggksndp
     2821 cylqspgdip sadaaemeeg fsespdnldh tenaasgsgp sargrsavtr rhkfdlaart
     2881 llaraaglyr svqahrnqsr regislqqdp galydfnlde eleidlddea meamfgqdlt
     2941 sdndilgmwi pehvcesedr eevvvcelce csvvsfnqhm krnhpgcgrs anrqgyrsng
     3001 syvdgwfgge cgsgnpyyll cgtcrekyla mktkskstss erykgqapdl igkqdsvyee
     3061 dwdmldvded ekltgeeefe llagplglnd rrivpepvqf pdsdplgasv amvtatnsme
     3121 etlmqigchg sveksssgri tlgeqaaala nphdrvvalr rvtaaaqvll artmvmrals
     3181 llsvsgsscs laagleslgl tdirtlvrlm claaagragl stspsamast sersrgghsk
     3241 ankpisclay lstavgclas napsaakllv qlctqnlisa atgvnlttvd dsiqrkflps
     3301 flrgiaeenk lvtspnfvvt qalvalladk gaklrpnydk sevekkgple lanalaaccl
     3361 ssrlssqhrq waaqqlvrtl aahdrdnqtt lqtladmggd lrkcsfikle ahqnrvmtcv
     3421 wcnkkgllat sgndgtirvw nvtkkqyslq qtcvfnrleg daeeslgsps dpsfspvsws
     3481 isgkylagal ekmvniwqvn ggkglvdiqp hwvsalawpe egpatawsge spelllvgrm
     3541 dgslglievv dvstmhrrel ehcyrkdvsv tciawfsedr pfavgyfdgk lllgtkeple
     3601 kggivlidah kdtlismkwd ptghilmtca kedsvklwgs isgcwcclhs lchpsivngi
     3661 awcrlpgkgs klqllmatgc qsglvcvwri pqdttqtnvt saegwweqes ncqdgyrkss
     3721 gakcvyqlrg hitpvrtvaf ssdglalvsg glgglmniws lrdgsvlqtv vigsgaiqtt
     3781 vwipevgvaa csnrskdvlv vnctaewaaa nhvlatcrta lkqqgvlgln mapcmrafle
     3841 rlpmmlqeqy ayekphvvcg dqlvhspymq claslavglh ldqllcnppv pphhqnclpd
     3901 paswnpnewa wlecfsttik aaealtngaq fpesftvpdl epvpedelvf lmdnskwing
     3961 mdeqimswat srpedwhlgg kcdvylwgag rhgqlaeagr nvmvpaaaps fsqaqqvicg
     4021 qnctfviqan gtvlacgegs ygrlgqgnsd dlhvltvisa lqgfvvtqlv tscgsdghsm
     4081 altesgevfs wgdgdygklg hgnsdrqrrp rqiealqgee vvqmscgfkh savvtsdgkl
     4141 ftfgngdygr lglgntsnkk lpervtaleg yqigqvacgl nhtlavsadg smvwafgdgd
     4201 ygklglgnst aksspqkidv lcgigikkva cgtqfsvalt kdghvytfgq drliglpegr
     4261 arnhnrpqqi pvlagviied vavgaehtla lasngdvyaw gsnsegqlgl ghtnhvrept
     4321 lvtglqgknv rqisagrchs aawtappvpp rapgvsvplq lglpdtvppq ygalrevsih
     4381 tvrarlrlly hfsdlmyssw rllnlspnnq nstshynagt wgivqgqlrp llaprvytlp
     4441 mvrsigktmv qgknygpqit vkristrgrk ckpifvqiar qvvklnasdl rlpsrawkvk
     4501 lvgegaddag gvfddtitem cqeletgivd llipspnata evgynrdrfl fnpsacldeh
     4561 lmqfkflgil mgvairtkkp ldlhlaplvw kqlccvpltl edleevdlly vqtlnsilhi
     4621 edsgiteesf hemipldsfv gqsadgkmvp iipggnsipl tfsnrkeyve raieyrlhem
     4681 drqvaavreg mswivpvpll slltakqleq mvcgmpeisv evlkkvvryr evdeqhqlvq
     4741 wfwhtleefs neervlfmrf vsgrsrlpan tadisqrfqi mkvdrpydsl ptsqtcffql
     4801 rlppyssqlv maerlryain ncrsidmdny mlsrnvdnae gsdtdy
//
LOCUS       XP_047289216            4845 aa            linear   PRI 05-AUG-2025
DEFINITION  putative E3 ubiquitin-protein ligase HERC1 isoform X34 [Homo
            sapiens].
ACCESSION   XP_047289216
VERSION     XP_047289216.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433260.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4845
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..4845
                     /product="putative E3 ubiquitin-protein ligase HERC1
                     isoform X34"
                     /calculated_mol_wt=530123
     Region          374..703
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          683..733
                     /region_name="RCC1"
                     /note="Regulator of chromosome condensation (RCC1) repeat;
                     pfam00415"
                     /db_xref="CDD:395335"
     Region          2031..2188
                     /region_name="SPRY_HERC1"
                     /note="SPRY domain in HERC1; cd12881"
                     /db_xref="CDD:293939"
     Region          2744..2787
                     /region_name="UBA_HERC1"
                     /note="UBA domain found in probable E3 ubiquitin-protein
                     ligase HERC1 and similar proteins; cd14401"
                     /db_xref="CDD:270584"
     Region          <3371..3762
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          3416..3459
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3473..3508
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3513..3560
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3569..3604
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3613..3649
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3656..3687
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3734..3770
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          3983..4319
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     Region          4457..4825
                     /region_name="HECTc"
                     /note="HECT domain; C-terminal catalytic domain of a
                     subclass of Ubiquitin-protein ligase (E3). It binds
                     specific ubiquitin-conjugating enzymes (E2), accepts
                     ubiquitin from E2, transfers ubiquitin to substrate lysine
                     side chains, and transfers additional...; cd00078"
                     /db_xref="CDD:238033"
     Site            order(4462,4503,4514,4581,4759,4789..4790,4793..4797,4817,
                     4824)
                     /site_type="active"
                     /note="catalytic cleft [active]"
                     /db_xref="CDD:238033"
     Site            order(4609,4612..4613,4615..4616,4619,4627,4629,
                     4633..4634,4636,4645,4650,4667,4671)
                     /site_type="active"
                     /note="E2 interaction site [active]"
                     /db_xref="CDD:238033"
     CDS             1..4845
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /coded_by="XM_047433260.1:149..14686"
                     /db_xref="GeneID:8925"
                     /db_xref="HGNC:HGNC:4867"
                     /db_xref="MIM:605109"
ORIGIN      
        1 matmippvkl kwlehlnssw itedsesiat regvavlysk lvsnkevvpl pqqvlclkgp
       61 qlpdferesl ssdeqdhyld allssqlala kmvcsdspfa galrkrllvl qrvfyalsnk
      121 yhdkgkvkqq qhspesssgs advhsvserp rsstdaliem gvrtglsllf allrqswmmp
      181 vsgpglslcn dvihtaievv sslpplslan eskippmgld clsqvttflk gvtipnsgad
      241 tlgrrlasel llglaaqrgs lryllewiem algasavvht mekgkllssq egmisfdcfm
      301 tilmqmrrsl gssadrsqwr eptrtsdglc slyeaalclf eevcrmasdy srtcaspdsi
      361 qtgdapivse tcevyvwgsn sshqlvegtq ekilqpklap sfsdaqtiea gqyctfvist
      421 dgsvracgkg sygrlglgds nnqstlkklt fephrsikkv ssskgsdght lafttegevf
      481 swgdgdygkl ghgnsstqky pkliqgplqg kvvvcvsagy rhsaavtedg elytwgegdf
      541 grlghgdsns rniptlvkdi snvgevscgs shtialskdg rtvwsfgggd ngklghgdtn
      601 rvykpkviea lqgmfirkvc agsqsslalt stgqvyawgc gaclgcgsse atalrpklie
      661 elaatrivdv sigdshclal shdnevyawg nnsmgqcgqg nstgpitkpk kvsgldgiai
      721 qqisagtshs lawtalprdr qvvawhrpyc vdleestfsh lrsflerycd kinseipplp
      781 fpssrehhsf lklclkllsn hlalalaggv atsilgrqag plrnllfrlm dstvpdeiqe
      841 vvietlsvga tmllpplrer mellhsllpq gpdrweslsk gqrmqldiil tslqdhthva
      901 sllgysspsd aadlssvctg ygnlsdqpyg tqschpdthl aeilmktllr nlgfytdqaf
      961 geleknsdkf llgtsssens qpahlhellc slqkqllafc hinnisenss svallhkhlq
     1021 lllphatdiy srsanllkes pwngsvgekl rdviyvsaag smlcqivnsl lllpvsvarp
     1081 llsylldllp pldclnrllp aadlledqel qwplhggpel idpaglplpq paqswvwlvd
     1141 lertiallig rclggmlqgs pvspeeqdta ywmktplfsd gvemdtpqld kcmsclleva
     1201 lsgneeqkpf dyklrpeiav yvdlalgcsk eparslwism qdyavskdwd satlsnesll
     1261 dtvsrfvlaa llkhtnllsq acgesryqpg khlsevyrcv ykvrsrllac knleliqtrs
     1321 ssrdrwisen qdsadvdpqe hsftrtidee aemeeqaerd reeghpeped eeeerehevm
     1381 tagkifqcfl sarevarsrd rdrmnsgags garaddpppq sqqerrvstd lpegqdvyta
     1441 acnsvihrca llilgvspvi delqkrreeg qlqqpstsas eggglmtrse sltaesrlvh
     1501 tspnyrliks rsesdlsqpe sdeegyalsg rrnvdldlaa shrkrgpmhs qleslsdswa
     1561 rlkhsrdwlc nssysfesdf dltkslgvht lienvvsfvs gdvgnapgfk epeesmstsp
     1621 qasiiameqq qlraelrlea lhqilvllsg meekgsisla gsrlssgfqs stlltsvrlq
     1681 flagcfglgt vghtggkges grlhhyqdgi raakrniqie iqvavhkiyq qlsatleral
     1741 qankhhieaq qrlllvtvfa lsvhyqpvdv slaistglln vlsqlcgtdt mlgqplqllp
     1801 ktgvsqlsta lkvastrllq ilaittgtya dklspkvvqs lldllcsqlk nllsqtgvlh
     1861 masfgegeqe dgeeeekkvd ssgetekkdf raalrkqhaa elhlgdflvf lrrvvsskai
     1921 qskmaspkwt evllniasqk cssgiplvgn lrtrllalhv leavlpaces gveddqmaqi
     1981 verlfsllsd cmwetpiaqa khaiqikeke qeiklqqgel eeedenlpiq evsfdpekaq
     2041 cclvengqil thgsggkgyg lastgvtsgc yqwkfyivke nrgnegtcvg vsrwpvhdfn
     2101 hrttsdmwly raysgnlyhn geqtltlssf tqgdfitcvl dmeartisfg kngeepklaf
     2161 edvdaaelyp cvmfyssnpg ekvkicdmqm rgtprdllpg dpicspvaav laeatiqlir
     2221 ilhrtdrwty cinkkmmerl hkikicikes gqklkksrsv qsreenemre ekeskeeekg
     2281 khtrhgladl selqlrtlci evwpvlavig gvdaglrvgg rcvhkqtgrh atllgvvkeg
     2341 stsakvqwde aeitisdtpl ynlepceplp fdvarfrglt asvlldltyl tgvhedmgkq
     2401 stkrhekkhr heseekgdve qkpesesald mrtgltsddv ksqsttssks eneiasfsld
     2461 ptlpsvesqh qitegkrknh ehmsknhdva qseiravqls ylylgamksl sallgcskya
     2521 elllipkvla enghnsdcas spvvhedvem raalqflmrh mvkravmrsp ikralgladl
     2581 eraqamiykl vvhglledqf ggkikqeidq qaeesdpaqq aqtpvttsps assttsfmss
     2641 sledtttatt pvtdtetvpa sespgvmpls llrqmfssyp tttvlptrra qtppisslpt
     2701 spsdevgrrq sltspdsqsa rpanrtalsd pssrlstspp ppaiavplle mgfslrqiak
     2761 ameatgarge adaqnitvla mwmiehpghe deeepqsgst adsrpgaavl gsggksndpc
     2821 ylqspgdips adaaemeegf sespdnldht enaasgsgps argrsavtrr hkfdlaartl
     2881 laraaglyrs vqahrnqsrr egislqqdpg alydfnldee leidlddeam eamfgqdlts
     2941 dndilgmwip ehvcesedre evvvcelcec svvsfnqhmk rnhpgcgrsa nrqgyrsngs
     3001 yvdgwfggec gsgnpyyllc gtcrekylam ktkskstsse rykgqapdli gkqdsvyeed
     3061 wdmldvdede kltgeeefel lagplglndr rivpepvqfp dsdplgasva mvtatnsmee
     3121 tlmqigchgs veksssgrit lgeqaaalan phdrvvalrr vtaaaqvlla rtmvmralsl
     3181 lsvsgsscsl aagleslglt dirtlvrlmc laaagragls tspsamasts ersrgghska
     3241 nkpisclayl stavgclasn apsaakllvq lctqnlisaa tgvnlttvdd siqrkflpsf
     3301 lrgiaeenkl vtspnfvvtq alvalladkg aklrpnydks evekkgplel analaaccls
     3361 srlssqhrqw aaqqlvrtla ahdrdnqttl qtladmggdl rkcsfiklea hqnrvmtcvw
     3421 cnkkgllats gndgtirvwn vtkkqyslqq tcvfnrlegd aeeslgspsd psfspvswsi
     3481 sgkylagale kmvniwqvng gkglvdiqph wvsalawpee gpatawsges pelllvgrmd
     3541 gslglievvd vstmhrrele hcyrkdvsvt ciawfsedrp favgyfdgkl llgtkeplek
     3601 ggivlidahk dtlismkwdp tghilmtcak edsvklwgsi sgcwcclhsl chpsivngia
     3661 wcrlpgkgsk lqllmatgcq sglvcvwrip qdttqtnvts aegwweqesn cqdgyrkssg
     3721 akcvyqlrgh itpvrtvafs sdglalvsgg lgglmniwsl rdgsvlqtvv igsgaiqttv
     3781 wipevgvaac snrskdvlvv nctaewaaan hvlatcrtal kqqgvlglnm apcmrafler
     3841 lpmmlqeqya yekphvvcgd qlvhspymqc laslavglhl dqllcnppvp phhqnclpdp
     3901 aswnpnewaw lecfsttika aealtngaqf pesftvpdle pvpedelvfl mdnskwingm
     3961 deqimswats rpedwhlggk cdvylwgagr hgqlaeagrn vmvpaaapsf sqaqqvicgq
     4021 nctfviqang tvlacgegsy grlgqgnsdd lhvltvisal qgfvvtqlvt scgsdghsma
     4081 ltesgevfsw gdgdygklgh gnsdrqrrpr qiealqgeev vqmscgfkhs avvtsdgklf
     4141 tfgngdygrl glgntsnkkl pervtalegy qigqvacgln htlavsadgs mvwafgdgdy
     4201 gklglgnsta ksspqkidvl cgigikkvac gtqfsvaltk dghvytfgqd rliglpegra
     4261 rnhnrpqqip vlagviiedv avgaehtlal asngdvyawg snsegqlglg htnhvreptl
     4321 vtglqgknvr qisagrchsa awtappvppr apgvsvplql glpdtvppqy galrevsiht
     4381 vrarlrllyh fsdlmysswr llnlspnnqn stshynagtw givqgqlrpl laprvytlpm
     4441 vrsigktmvq gknygpqitv kristrgrkc kpifvqiarq vvklnasdlr lpsrawkvkl
     4501 vgegaddagg vfddtitemc qeletgivdl lipspnatae vgynrdrflf npsacldehl
     4561 mqfkflgilm gvairtkkpl dlhlaplvwk qlccvpltle dleevdllyv qtlnsilhie
     4621 dsgiteesfh emipldsfvg qsadgkmvpi ipggnsiplt fsnrkeyver aieyrlhemd
     4681 rqvaavregm swivpvplls lltakqleqm vcgmpeisve vlkkvvryre vdeqhqlvqw
     4741 fwhtleefsn eervlfmrfv sgrsrlpant adisqrfqim kvdrpydslp tsqtcffqlr
     4801 lppyssqlvm aerlryainn crsidmdnym lsrnvdnaeg sdtdy
//
LOCUS       XP_011520455             412 aa            linear   PRI 05-AUG-2025
DEFINITION  CHRNA7-FAM7A fusion protein isoform X1 [Homo sapiens].
ACCESSION   XP_011520455
VERSION     XP_011520455.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522153.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..412
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..412
                     /product="CHRNA7-FAM7A fusion protein isoform X1"
                     /calculated_mol_wt=46087
     Region          <28..400
                     /region_name="LIC"
                     /note="Cation transporter family protein; cl42365"
                     /db_xref="CDD:455710"
     CDS             1..412
                     /gene="CHRFAM7A"
                     /gene_synonym="CHRNA7; CHRNA7-DR1; D-10; NACHRA7"
                     /coded_by="XM_011522153.3:312..1550"
                     /db_xref="GeneID:89832"
                     /db_xref="HGNC:HGNC:15781"
                     /db_xref="MIM:609756"
ORIGIN      
        1 mqkyciyqhf qfqlliqhlw iaancdiade rfdatfhtnv lvnssghcqy lppgifkssc
       61 yidvrwfpfd vqhcklkfgs wsyggwsldl qmqeadisgy ipngewdlvg ipgkrserfy
      121 ecckepypdv tftvtmrrrt lyyglnllip cvlisalall vfllpadsge kislgitvll
      181 sltvfmllva eimpatsdsv pliaqyfast miivglsvvv tvivlqyhhh dpdggkmpkw
      241 trvillnwca wflrmkrpge dkvrpacqhk qrrcslasve msavapppas ngnllyigfr
      301 gldgvhcvpt pdsgvvcgrm acspthdehl lhggqppegd pdlakileev ryianrfrcq
      361 deseavcsew kfaacvvdrl clmafsvfti ictigilmsa pnfveavskd fa
//
LOCUS       XP_005254807             321 aa            linear   PRI 05-AUG-2025
DEFINITION  CHRNA7-FAM7A fusion protein isoform X2 [Homo sapiens].
ACCESSION   XP_005254807
VERSION     XP_005254807.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254750.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..321
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..321
                     /product="CHRNA7-FAM7A fusion protein isoform X2"
                     /calculated_mol_wt=35351
     Region          <3..309
                     /region_name="LIC"
                     /note="Cation transporter family protein; cl42365"
                     /db_xref="CDD:455710"
     CDS             1..321
                     /gene="CHRFAM7A"
                     /gene_synonym="CHRNA7; CHRNA7-DR1; D-10; NACHRA7"
                     /coded_by="XM_005254750.4:1014..1979"
                     /db_xref="GeneID:89832"
                     /db_xref="HGNC:HGNC:15781"
                     /db_xref="MIM:609756"
ORIGIN      
        1 mqeadisgyi pngewdlvgi pgkrserfye cckepypdvt ftvtmrrrtl yyglnllipc
       61 vlisalallv fllpadsgek islgitvlls ltvfmllvae impatsdsvp liaqyfastm
      121 iivglsvvvt vivlqyhhhd pdggkmpkwt rvillnwcaw flrmkrpged kvrpacqhkq
      181 rrcslasvem savapppasn gnllyigfrg ldgvhcvptp dsgvvcgrma cspthdehll
      241 hggqppegdp dlakileevr yianrfrcqd eseavcsewk faacvvdrlc lmafsvftii
      301 ctigilmsap nfveavskdf a
//
LOCUS       XP_011520457             290 aa            linear   PRI 05-AUG-2025
DEFINITION  CHRNA7-FAM7A fusion protein isoform X3 [Homo sapiens].
ACCESSION   XP_011520457
VERSION     XP_011520457.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522155.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..290
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..290
                     /product="CHRNA7-FAM7A fusion protein isoform X3"
                     /calculated_mol_wt=32276
     Region          <28..139
                     /region_name="LGIC_ECD"
                     /note="extracellular domain (ECD) of Cys-loop
                     neurotransmitter-gated ion channels (also known as
                     ligand-gated ion channel (LGIC)); cl28912"
                     /db_xref="CDD:475126"
     Region          141..>203
                     /region_name="LGIC_TM_cation"
                     /note="transmembrane domain of Cys-loop
                     neurotransmitter-gated ion channels, includes 5HT3, nAChR,
                     and ZAC; cd19051"
                     /db_xref="CDD:349853"
     Region          141..165
                     /region_name="TM1 helix"
                     /note="TM1 helix [structural motif]"
                     /db_xref="CDD:349853"
     Region          173..194
                     /region_name="TM2 helix"
                     /note="TM2 helix [structural motif]"
                     /db_xref="CDD:349853"
     CDS             1..290
                     /gene="CHRFAM7A"
                     /gene_synonym="CHRNA7; CHRNA7-DR1; D-10; NACHRA7"
                     /coded_by="XM_011522155.4:567..1439"
                     /db_xref="GeneID:89832"
                     /db_xref="HGNC:HGNC:15781"
                     /db_xref="MIM:609756"
ORIGIN      
        1 mqkyciyqhf qfqlliqhlw iaancdiade rfdatfhtnv lvnssghcqy lppgifkssc
       61 yidvrwfpfd vqhcklkfgs wsyggwsldl qmqeadisgy ipngewdlvg ipgkrserfy
      121 ecckepypdv tftvtmrrrt lyyglnllip cvlisalall vfllpadsge kislgitvll
      181 sltvfmllva eimpatsdsv plidqshpse lvrvvpanee arggqgapgl paqaaalqpg
      241 qcgdecrgaa arqqrepavh rlprpgrral cpdprlwgsv wphgllphar
//
LOCUS       XP_016878197             271 aa            linear   PRI 05-AUG-2025
DEFINITION  diphthine--ammonia ligase isoform X1 [Homo sapiens].
ACCESSION   XP_016878197
VERSION     XP_016878197.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022708.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..271
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..271
                     /product="diphthine--ammonia ligase isoform X1"
                     /calculated_mol_wt=30530
     Region          2..219
                     /region_name="AANH_PF0828-like"
                     /note="putative ATP pyrophosphatase PF0828 and similar
                     proteins; cd01994"
                     /db_xref="CDD:467498"
     CDS             1..271
                     /gene="DPH6"
                     /gene_synonym="ATPBD4"
                     /coded_by="XM_017022708.3:25..840"
                     /db_xref="GeneID:89978"
                     /db_xref="HGNC:HGNC:30543"
                     /db_xref="MIM:618391"
ORIGIN      
        1 mrvaalisgg kdscynmmqc iaaghqival anlrpaenqv gsdeldsymy qtvghhaidl
       61 yaeamalply rrtirgrsld trqvytkceg devedlyell klvkekeeve gisvgailsd
      121 yqrirvenvc krlnlqplay lwqrnqedll remissniqa miikvaalgl dpdkhlgktl
      181 dqmepyliel skkygvhvcg eggeyetftl dcplfkkkii vdssevvihs adafapvayl
      241 rflelhledk cdayqhvmmq qegshqmvas l
//
LOCUS       XP_011520462             254 aa            linear   PRI 05-AUG-2025
DEFINITION  diphthine--ammonia ligase isoform X2 [Homo sapiens].
ACCESSION   XP_011520462
VERSION     XP_011520462.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522160.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..254
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..254
                     /product="diphthine--ammonia ligase isoform X2"
                     /calculated_mol_wt=28540
     Region          2..219
                     /region_name="AANH_PF0828-like"
                     /note="putative ATP pyrophosphatase PF0828 and similar
                     proteins; cd01994"
                     /db_xref="CDD:467498"
     CDS             1..254
                     /gene="DPH6"
                     /gene_synonym="ATPBD4"
                     /coded_by="XM_011522160.3:25..789"
                     /db_xref="GeneID:89978"
                     /db_xref="HGNC:HGNC:30543"
                     /db_xref="MIM:618391"
ORIGIN      
        1 mrvaalisgg kdscynmmqc iaaghqival anlrpaenqv gsdeldsymy qtvghhaidl
       61 yaeamalply rrtirgrsld trqvytkceg devedlyell klvkekeeve gisvgailsd
      121 yqrirvenvc krlnlqplay lwqrnqedll remissniqa miikvaalgl dpdkhlgktl
      181 dqmepyliel skkygvhvcg eggeyetftl dcplfkkkii vdssevvihs adafapvayl
      241 rflelhledk grta
//
LOCUS       XP_047289219             254 aa            linear   PRI 05-AUG-2025
DEFINITION  diphthine--ammonia ligase isoform X2 [Homo sapiens].
ACCESSION   XP_047289219
VERSION     XP_047289219.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433263.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..254
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..254
                     /product="diphthine--ammonia ligase isoform X2"
                     /calculated_mol_wt=28540
     Region          2..219
                     /region_name="AANH_PF0828-like"
                     /note="putative ATP pyrophosphatase PF0828 and similar
                     proteins; cd01994"
                     /db_xref="CDD:467498"
     CDS             1..254
                     /gene="DPH6"
                     /gene_synonym="ATPBD4"
                     /coded_by="XM_047433263.1:25..789"
                     /db_xref="GeneID:89978"
                     /db_xref="HGNC:HGNC:30543"
                     /db_xref="MIM:618391"
ORIGIN      
        1 mrvaalisgg kdscynmmqc iaaghqival anlrpaenqv gsdeldsymy qtvghhaidl
       61 yaeamalply rrtirgrsld trqvytkceg devedlyell klvkekeeve gisvgailsd
      121 yqrirvenvc krlnlqplay lwqrnqedll remissniqa miikvaalgl dpdkhlgktl
      181 dqmepyliel skkygvhvcg eggeyetftl dcplfkkkii vdssevvihs adafapvayl
      241 rflelhledk grta
//
LOCUS       XP_047289220             254 aa            linear   PRI 05-AUG-2025
DEFINITION  diphthine--ammonia ligase isoform X2 [Homo sapiens].
ACCESSION   XP_047289220
VERSION     XP_047289220.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433264.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..254
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..254
                     /product="diphthine--ammonia ligase isoform X2"
                     /calculated_mol_wt=28540
     Region          2..219
                     /region_name="AANH_PF0828-like"
                     /note="putative ATP pyrophosphatase PF0828 and similar
                     proteins; cd01994"
                     /db_xref="CDD:467498"
     CDS             1..254
                     /gene="DPH6"
                     /gene_synonym="ATPBD4"
                     /coded_by="XM_047433264.1:25..789"
                     /db_xref="GeneID:89978"
                     /db_xref="HGNC:HGNC:30543"
                     /db_xref="MIM:618391"
ORIGIN      
        1 mrvaalisgg kdscynmmqc iaaghqival anlrpaenqv gsdeldsymy qtvghhaidl
       61 yaeamalply rrtirgrsld trqvytkceg devedlyell klvkekeeve gisvgailsd
      121 yqrirvenvc krlnlqplay lwqrnqedll remissniqa miikvaalgl dpdkhlgktl
      181 dqmepyliel skkygvhvcg eggeyetftl dcplfkkkii vdssevvihs adafapvayl
      241 rflelhledk grta
//
LOCUS       XP_047289221             254 aa            linear   PRI 05-AUG-2025
DEFINITION  diphthine--ammonia ligase isoform X2 [Homo sapiens].
ACCESSION   XP_047289221
VERSION     XP_047289221.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433265.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..254
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..254
                     /product="diphthine--ammonia ligase isoform X2"
                     /calculated_mol_wt=28540
     Region          2..219
                     /region_name="AANH_PF0828-like"
                     /note="putative ATP pyrophosphatase PF0828 and similar
                     proteins; cd01994"
                     /db_xref="CDD:467498"
     CDS             1..254
                     /gene="DPH6"
                     /gene_synonym="ATPBD4"
                     /coded_by="XM_047433265.1:25..789"
                     /db_xref="GeneID:89978"
                     /db_xref="HGNC:HGNC:30543"
                     /db_xref="MIM:618391"
ORIGIN      
        1 mrvaalisgg kdscynmmqc iaaghqival anlrpaenqv gsdeldsymy qtvghhaidl
       61 yaeamalply rrtirgrsld trqvytkceg devedlyell klvkekeeve gisvgailsd
      121 yqrirvenvc krlnlqplay lwqrnqedll remissniqa miikvaalgl dpdkhlgktl
      181 dqmepyliel skkygvhvcg eggeyetftl dcplfkkkii vdssevvihs adafapvayl
      241 rflelhledk grta
//
LOCUS       XP_016878198             199 aa            linear   PRI 05-AUG-2025
DEFINITION  diphthine--ammonia ligase isoform X3 [Homo sapiens].
ACCESSION   XP_016878198
VERSION     XP_016878198.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022709.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..199
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..199
                     /product="diphthine--ammonia ligase isoform X3"
                     /calculated_mol_wt=22435
     Region          2..189
                     /region_name="AANH_PF0828-like"
                     /note="putative ATP pyrophosphatase PF0828 and similar
                     proteins; cd01994"
                     /db_xref="CDD:467498"
     CDS             1..199
                     /gene="DPH6"
                     /gene_synonym="ATPBD4"
                     /coded_by="XM_017022709.3:25..624"
                     /db_xref="GeneID:89978"
                     /db_xref="HGNC:HGNC:30543"
                     /db_xref="MIM:618391"
ORIGIN      
        1 mrvaalisgg kdscynmmqc iaaghqival anlrpaenqv gsdeldsymy qtvghhaidl
       61 yaeamalply rrtirgrsld trqvytkceg devedlyell klvkekeeve gisvgailsd
      121 yqrirvenvc krlnlqplay lwqrnqedll remissniqa miikvaalgl dpdkhlgktl
      181 dqmepylieg firsshtfs
//
LOCUS       XP_011520470             435 aa            linear   PRI 05-AUG-2025
DEFINITION  proline-serine-threonine phosphatase-interacting protein 1 isoform
            X1 [Homo sapiens].
ACCESSION   XP_011520470
VERSION     XP_011520470.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522168.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..435
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..435
                     /product="proline-serine-threonine phosphatase-interacting
                     protein 1 isoform X1"
                     /calculated_mol_wt=49580
     Region          16..276
                     /region_name="BAR"
                     /note="The Bin/Amphiphysin/Rvs (BAR) domain, a
                     dimerization module that binds membranes and detects
                     membrane curvature; cl12013"
                     /db_xref="CDD:472257"
     Site            order(21,24..25,29,31..32,35..36,38..39,49..50,52..53,
                     56..57,59..60,63,86,89..90,232,235..236,238,240,243..244,
                     246..247,250..251,254..255,257..258,261..262,264..265)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:153355"
     Region          382..434
                     /region_name="SH3_PSTPIP1"
                     /note="Src homology 3 domain of Proline-Serine-Threonine
                     Phosphatase-Interacting Protein 1; cd11824"
                     /db_xref="CDD:212758"
     Site            order(387,389,392,396,414..415,428,430..431)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212758"
     CDS             1..435
                     /gene="PSTPIP1"
                     /gene_synonym="AICZC; CD2BP1; CD2BP1L; CD2BP1S; H-PIP;
                     PAPA; PAPAS; PSTPIP"
                     /coded_by="XM_011522168.4:449..1756"
                     /db_xref="GeneID:9051"
                     /db_xref="HGNC:HGNC:9580"
                     /db_xref="MIM:606347"
ORIGIN      
        1 mmpqlqfkda fwcrdftaht gyevllqrll dgrkmckdme ellrqraqae erygkelvqi
       61 arkaggqtei nslrasfdsl kqqmenvgss hiqlaltlre elrsleefre rqkeqrkkgm
      121 avprqsdcme vkspsweyea vmdrvqkskl slykkamesk ktyeqkcrda ddaeqaferi
      181 sanghqkqve ksqnkarqck dsateaervy rqsiaqlekv raeweqehrt tceafqlqef
      241 drltilrnal wvhsnqlsmq cvkddelyee vrltlegcsi dadidsfiqa kstgteppap
      301 vpyqnyydre vtpltsspgi qpscgmikrf sgllhgspkt tslaasaast etltptpern
      361 egvytaiavq eiqgnpaspa qeyralydyt aqnpdeldls agdilevile gedgwwtver
      421 ngqrgfvpgs ylekl
//
LOCUS       XP_011520465             432 aa            linear   PRI 05-AUG-2025
DEFINITION  proline-serine-threonine phosphatase-interacting protein 1 isoform
            X2 [Homo sapiens].
ACCESSION   XP_011520465
VERSION     XP_011520465.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522163.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..432
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..432
                     /product="proline-serine-threonine phosphatase-interacting
                     protein 1 isoform X2"
                     /calculated_mol_wt=49321
     Region          16..276
                     /region_name="BAR"
                     /note="The Bin/Amphiphysin/Rvs (BAR) domain, a
                     dimerization module that binds membranes and detects
                     membrane curvature; cl12013"
                     /db_xref="CDD:472257"
     Site            order(21,24..25,29,31..32,35..36,38..39,49..50,52..53,
                     56..57,59..60,63,86,89..90,232,235..236,238,240,243..244,
                     246..247,250..251,254..255,257..258,261..262,264..265)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:153355"
     Region          379..431
                     /region_name="SH3_PSTPIP1"
                     /note="Src homology 3 domain of Proline-Serine-Threonine
                     Phosphatase-Interacting Protein 1; cd11824"
                     /db_xref="CDD:212758"
     Site            order(384,386,389,393,411..412,425,427..428)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212758"
     CDS             1..432
                     /gene="PSTPIP1"
                     /gene_synonym="AICZC; CD2BP1; CD2BP1L; CD2BP1S; H-PIP;
                     PAPA; PAPAS; PSTPIP"
                     /coded_by="XM_011522163.3:449..1747"
                     /db_xref="GeneID:9051"
                     /db_xref="HGNC:HGNC:9580"
                     /db_xref="MIM:606347"
ORIGIN      
        1 mmpqlqfkda fwcrdftaht gyevllqrll dgrkmckdme ellrqraqae erygkelvqi
       61 arkaggqtei nslrasfdsl kqqmenvgss hiqlaltlre elrsleefre rqkeqrkkgm
      121 avprqsdcme vkspsweyea vmdrvqkskl slykkamesk ktyeqkcrda ddaeqaferi
      181 sanghqkqve ksqnkarqck dsateaervy rqsiaqlekv raeweqehrt tceafqlqef
      241 drltilrnal wvhsnqlsmq cvkddelyee vrltlegcsi dadidsfiqa kstgteppap
      301 vpyqnyydre vtpltsspgi qpscgmikrf sgllhgspkt tslaasaetl tptpernegv
      361 ytaiavqeiq gnpaspaqey ralydytaqn pdeldlsagd ilevileged gwwtverngq
      421 rgfvpgsyle kl
//
LOCUS       XP_047289232             371 aa            linear   PRI 05-AUG-2025
DEFINITION  proline-serine-threonine phosphatase-interacting protein 1 isoform
            X3 [Homo sapiens].
ACCESSION   XP_047289232
VERSION     XP_047289232.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433276.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..371
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..371
                     /product="proline-serine-threonine phosphatase-interacting
                     protein 1 isoform X3"
                     /calculated_mol_wt=42678
     Region          16..276
                     /region_name="BAR"
                     /note="The Bin/Amphiphysin/Rvs (BAR) domain, a
                     dimerization module that binds membranes and detects
                     membrane curvature; cl12013"
                     /db_xref="CDD:472257"
     Site            order(21,24..25,29,31..32,35..36,38..39,49..50,52..53,
                     56..57,59..60,63,86,89..90,232,235..236,238,240,243..244,
                     246..247,250..251,254..255,257..258,261..262,264..265)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:153355"
     CDS             1..371
                     /gene="PSTPIP1"
                     /gene_synonym="AICZC; CD2BP1; CD2BP1L; CD2BP1S; H-PIP;
                     PAPA; PAPAS; PSTPIP"
                     /coded_by="XM_047433276.1:449..1564"
                     /db_xref="GeneID:9051"
                     /db_xref="HGNC:HGNC:9580"
                     /db_xref="MIM:606347"
ORIGIN      
        1 mmpqlqfkda fwcrdftaht gyevllqrll dgrkmckdme ellrqraqae erygkelvqi
       61 arkaggqtei nslrasfdsl kqqmenvgss hiqlaltlre elrsleefre rqkeqrkkgm
      121 avprqsdcme vkspsweyea vmdrvqkskl slykkamesk ktyeqkcrda ddaeqaferi
      181 sanghqkqve ksqnkarqck dsateaervy rqsiaqlekv raeweqehrt tceafqlqef
      241 drltilrnal wvhsnqlsmq cvkddelyee vrltlegcsi dadidsfiqa kstgteppge
      301 vrladsaass sgalpellrs gghpadqqpw htavlrhdke vlwtaarksq dhfvgsfccv
      361 hrdpdphpra e
//
LOCUS       XP_011520467             367 aa            linear   PRI 05-AUG-2025
DEFINITION  proline-serine-threonine phosphatase-interacting protein 1 isoform
            X4 [Homo sapiens].
ACCESSION   XP_011520467
VERSION     XP_011520467.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522165.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..367
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..367
                     /product="proline-serine-threonine phosphatase-interacting
                     protein 1 isoform X4"
                     /calculated_mol_wt=41522
     Region          <4..208
                     /region_name="BAR"
                     /note="The Bin/Amphiphysin/Rvs (BAR) domain, a
                     dimerization module that binds membranes and detects
                     membrane curvature; cl12013"
                     /db_xref="CDD:472257"
     Region          314..366
                     /region_name="SH3_PSTPIP1"
                     /note="Src homology 3 domain of Proline-Serine-Threonine
                     Phosphatase-Interacting Protein 1; cd11824"
                     /db_xref="CDD:212758"
     Site            order(319,321,324,328,346..347,360,362..363)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212758"
     CDS             1..367
                     /gene="PSTPIP1"
                     /gene_synonym="AICZC; CD2BP1; CD2BP1L; CD2BP1S; H-PIP;
                     PAPA; PAPAS; PSTPIP"
                     /coded_by="XM_011522165.3:211..1314"
                     /db_xref="GeneID:9051"
                     /db_xref="HGNC:HGNC:9580"
                     /db_xref="MIM:606347"
ORIGIN      
        1 mpsslrasfd slkqqmenvg sshiqlaltl reelrsleef rerqkeqrkk gmavprqsdc
       61 mevkspswey eavmdrvqks klslykkame skktyeqkcr daddaeqafe risanghqkq
      121 veksqnkarq ckdsateaer vyrqsiaqle kvraeweqeh rttceafqlq efdrltilrn
      181 alwvhsnqls mqcvkddely eevrltlegc sidadidsfi qakstgtepp apvpyqnyyd
      241 revtpltssp giqpscgmik rfsgllhgsp kttslaasaa stetltptpe rnegvytaia
      301 vqeiqgnpas paqeyralyd ytaqnpdeld lsagdilevi legedgwwtv erngqrgfvp
      361 gsylekl
//
LOCUS       XP_011520468             358 aa            linear   PRI 05-AUG-2025
DEFINITION  proline-serine-threonine phosphatase-interacting protein 1 isoform
            X5 [Homo sapiens].
ACCESSION   XP_011520468
VERSION     XP_011520468.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522166.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..358
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..358
                     /product="proline-serine-threonine phosphatase-interacting
                     protein 1 isoform X5"
                     /calculated_mol_wt=41168
     Region          16..276
                     /region_name="BAR"
                     /note="The Bin/Amphiphysin/Rvs (BAR) domain, a
                     dimerization module that binds membranes and detects
                     membrane curvature; cl12013"
                     /db_xref="CDD:472257"
     Site            order(21,24..25,29,31..32,35..36,38..39,49..50,52..53,
                     56..57,59..60,63,86,89..90,232,235..236,238,240,243..244,
                     246..247,250..251,254..255,257..258,261..262,264..265)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:153355"
     CDS             1..358
                     /gene="PSTPIP1"
                     /gene_synonym="AICZC; CD2BP1; CD2BP1L; CD2BP1S; H-PIP;
                     PAPA; PAPAS; PSTPIP"
                     /coded_by="XM_011522166.2:449..1525"
                     /db_xref="GeneID:9051"
                     /db_xref="HGNC:HGNC:9580"
                     /db_xref="MIM:606347"
ORIGIN      
        1 mmpqlqfkda fwcrdftaht gyevllqrll dgrkmckdme ellrqraqae erygkelvqi
       61 arkaggqtei nslrasfdsl kqqmenvgss hiqlaltlre elrsleefre rqkeqrkkgm
      121 avprqsdcme vkspsweyea vmdrvqkskl slykkamesk ktyeqkcrda ddaeqaferi
      181 sanghqkqve ksqnkarqck dsateaervy rqsiaqlekv raeweqehrt tceafqlqef
      241 drltilrnal wvhsnqlsmq cvkddelyee vrltlegcsi dadidsfiqa kstgteppge
      301 vrladsaass sgalpellrs gghpadqqpw htavlrhdke vlwtaarksq dhfvgsfc
//
LOCUS       XP_047289233             352 aa            linear   PRI 05-AUG-2025
DEFINITION  proline-serine-threonine phosphatase-interacting protein 1 isoform
            X6 [Homo sapiens].
ACCESSION   XP_047289233
VERSION     XP_047289233.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433277.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..352
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..352
                     /product="proline-serine-threonine phosphatase-interacting
                     protein 1 isoform X6"
                     /calculated_mol_wt=40559
     Region          16..257
                     /region_name="BAR"
                     /note="The Bin/Amphiphysin/Rvs (BAR) domain, a
                     dimerization module that binds membranes and detects
                     membrane curvature; cl12013"
                     /db_xref="CDD:472257"
     Site            order(21,24..25,29,31..32,35..36,38..39,49..50,52..53,
                     56..57,59..60,63,86,89..90,213,216..217,219,221,224..225,
                     227..228,231..232,235..236,238..239,242..243,245..246)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:153355"
     CDS             1..352
                     /gene="PSTPIP1"
                     /gene_synonym="AICZC; CD2BP1; CD2BP1L; CD2BP1S; H-PIP;
                     PAPA; PAPAS; PSTPIP"
                     /coded_by="XM_047433277.1:449..1507"
                     /db_xref="GeneID:9051"
                     /db_xref="HGNC:HGNC:9580"
                     /db_xref="MIM:606347"
ORIGIN      
        1 mmpqlqfkda fwcrdftaht gyevllqrll dgrkmckdme ellrqraqae erygkelvqi
       61 arkaggqtei nslrasfdsl kqqmenvgss hiqlaltlre elrsleefre rqkeqrkkye
      121 avmdrvqksk lslykkames kktyeqkcrd addaeqafer isanghqkqv eksqnkarqc
      181 kdsateaerv yrqsiaqlek vraeweqehr ttceafqlqe fdrltilrna lwvhsnqlsm
      241 qcvkddelye evrltlegcs idadidsfiq akstgteppg evrladsaas ssgalpellr
      301 sgghpadqqp whtavlrhdk evlwtaarks qdhfvgsfcc vhrdpdphpr ae
//
LOCUS       XP_047289234             348 aa            linear   PRI 05-AUG-2025
DEFINITION  proline-serine-threonine phosphatase-interacting protein 1 isoform
            X7 [Homo sapiens].
ACCESSION   XP_047289234
VERSION     XP_047289234.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433278.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..348
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..348
                     /product="proline-serine-threonine phosphatase-interacting
                     protein 1 isoform X7"
                     /calculated_mol_wt=39402
     Region          <4..189
                     /region_name="BAR"
                     /note="The Bin/Amphiphysin/Rvs (BAR) domain, a
                     dimerization module that binds membranes and detects
                     membrane curvature; cl12013"
                     /db_xref="CDD:472257"
     Region          295..347
                     /region_name="SH3_PSTPIP1"
                     /note="Src homology 3 domain of Proline-Serine-Threonine
                     Phosphatase-Interacting Protein 1; cd11824"
                     /db_xref="CDD:212758"
     Site            order(300,302,305,309,327..328,341,343..344)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212758"
     CDS             1..348
                     /gene="PSTPIP1"
                     /gene_synonym="AICZC; CD2BP1; CD2BP1L; CD2BP1S; H-PIP;
                     PAPA; PAPAS; PSTPIP"
                     /coded_by="XM_047433278.1:158..1204"
                     /db_xref="GeneID:9051"
                     /db_xref="HGNC:HGNC:9580"
                     /db_xref="MIM:606347"
ORIGIN      
        1 mpsslrasfd slkqqmenvg sshiqlaltl reelrsleef rerqkeqrkk yeavmdrvqk
       61 sklslykkam eskktyeqkc rdaddaeqaf erisanghqk qveksqnkar qckdsateae
      121 rvyrqsiaql ekvraeweqe hrttceafql qefdrltilr nalwvhsnql smqcvkddel
      181 yeevrltleg csidadidsf iqakstgtep papvpyqnyy drevtpltss pgiqpscgmi
      241 krfsgllhgs pkttslaasa astetltptp ernegvytai avqeiqgnpa spaqeyraly
      301 dytaqnpdel dlsagdilev ilegedgwwt verngqrgfv pgsylekl
//
LOCUS       XP_047289236             322 aa            linear   PRI 05-AUG-2025
DEFINITION  proline-serine-threonine phosphatase-interacting protein 1 isoform
            X8 [Homo sapiens].
ACCESSION   XP_047289236
VERSION     XP_047289236.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433280.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..322
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..322
                     /product="proline-serine-threonine phosphatase-interacting
                     protein 1 isoform X8"
                     /calculated_mol_wt=37520
     Region          16..276
                     /region_name="BAR"
                     /note="The Bin/Amphiphysin/Rvs (BAR) domain, a
                     dimerization module that binds membranes and detects
                     membrane curvature; cl12013"
                     /db_xref="CDD:472257"
     Site            order(21,24..25,29,31..32,35..36,38..39,49..50,52..53,
                     56..57,59..60,63,86,89..90,232,235..236,238,240,243..244,
                     246..247,250..251,254..255,257..258,261..262,264..265)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:153355"
     CDS             1..322
                     /gene="PSTPIP1"
                     /gene_synonym="AICZC; CD2BP1; CD2BP1L; CD2BP1S; H-PIP;
                     PAPA; PAPAS; PSTPIP"
                     /coded_by="XM_047433280.1:449..1417"
                     /db_xref="GeneID:9051"
                     /db_xref="HGNC:HGNC:9580"
                     /db_xref="MIM:606347"
ORIGIN      
        1 mmpqlqfkda fwcrdftaht gyevllqrll dgrkmckdme ellrqraqae erygkelvqi
       61 arkaggqtei nslrasfdsl kqqmenvgss hiqlaltlre elrsleefre rqkeqrkkgm
      121 avprqsdcme vkspsweyea vmdrvqkskl slykkamesk ktyeqkcrda ddaeqaferi
      181 sanghqkqve ksqnkarqck dsateaervy rqsiaqlekv raeweqehrt tceafqlqef
      241 drltilrnal wvhsnqlsmq cvkddelyee vrltlegcsi dadidsfiqa kstgteppgs
      301 ldcctevprp lrwqlllrpq rp
//
LOCUS       XP_011520469             319 aa            linear   PRI 05-AUG-2025
DEFINITION  proline-serine-threonine phosphatase-interacting protein 1 isoform
            X9 [Homo sapiens].
ACCESSION   XP_011520469
VERSION     XP_011520469.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522167.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..319
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..319
                     /product="proline-serine-threonine phosphatase-interacting
                     protein 1 isoform X9"
                     /calculated_mol_wt=37138
     Region          16..276
                     /region_name="BAR"
                     /note="The Bin/Amphiphysin/Rvs (BAR) domain, a
                     dimerization module that binds membranes and detects
                     membrane curvature; cl12013"
                     /db_xref="CDD:472257"
     Site            order(21,24..25,29,31..32,35..36,38..39,49..50,52..53,
                     56..57,59..60,63,86,89..90,232,235..236,238,240,243..244,
                     246..247,250..251,254..255,257..258,261..262,264..265)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:153355"
     CDS             1..319
                     /gene="PSTPIP1"
                     /gene_synonym="AICZC; CD2BP1; CD2BP1L; CD2BP1S; H-PIP;
                     PAPA; PAPAS; PSTPIP"
                     /coded_by="XM_011522167.2:449..1408"
                     /db_xref="GeneID:9051"
                     /db_xref="HGNC:HGNC:9580"
                     /db_xref="MIM:606347"
ORIGIN      
        1 mmpqlqfkda fwcrdftaht gyevllqrll dgrkmckdme ellrqraqae erygkelvqi
       61 arkaggqtei nslrasfdsl kqqmenvgss hiqlaltlre elrsleefre rqkeqrkkgm
      121 avprqsdcme vkspsweyea vmdrvqkskl slykkamesk ktyeqkcrda ddaeqaferi
      181 sanghqkqve ksqnkarqck dsateaervy rqsiaqlekv raeweqehrt tceafqlqef
      241 drltilrnal wvhsnqlsmq cvkddelyee vrltlegcsi dadidsfiqa kstgteppgs
      301 ldcctevprp lrwqlllrp
//
LOCUS       XP_047289237             297 aa            linear   PRI 05-AUG-2025
DEFINITION  proline-serine-threonine phosphatase-interacting protein 1 isoform
            X10 [Homo sapiens].
ACCESSION   XP_047289237
VERSION     XP_047289237.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433281.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..297
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..297
                     /product="proline-serine-threonine phosphatase-interacting
                     protein 1 isoform X10"
                     /calculated_mol_wt=34767
     Region          16..266
                     /region_name="BAR"
                     /note="The Bin/Amphiphysin/Rvs (BAR) domain, a
                     dimerization module that binds membranes and detects
                     membrane curvature; cl12013"
                     /db_xref="CDD:472257"
     Site            order(21,24..25,29,31..32,35..36,38..39,49..50,52..53,
                     56..57,59..60,63,86,89..90,232,235..236,238,240,243..244,
                     246..247,250..251,254..255,257..258,261..262,264..265)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:153355"
     CDS             1..297
                     /gene="PSTPIP1"
                     /gene_synonym="AICZC; CD2BP1; CD2BP1L; CD2BP1S; H-PIP;
                     PAPA; PAPAS; PSTPIP"
                     /coded_by="XM_047433281.1:449..1342"
                     /db_xref="GeneID:9051"
                     /db_xref="HGNC:HGNC:9580"
                     /db_xref="MIM:606347"
ORIGIN      
        1 mmpqlqfkda fwcrdftaht gyevllqrll dgrkmckdme ellrqraqae erygkelvqi
       61 arkaggqtei nslrasfdsl kqqmenvgss hiqlaltlre elrsleefre rqkeqrkkgm
      121 avprqsdcme vkspsweyea vmdrvqkskl slykkamesk ktyeqkcrda ddaeqaferi
      181 sanghqkqve ksqnkarqck dsateaervy rqsiaqlekv raeweqehrt tceafqlqef
      241 drltilrnal wvhsnqlsmq cvkddevlwt aarksqdhfv gsfccvhrdp dphprae
//
LOCUS       XP_006720800             294 aa            linear   PRI 05-AUG-2025
DEFINITION  proline-serine-threonine phosphatase-interacting protein 1 isoform
            X11 [Homo sapiens].
ACCESSION   XP_006720800
VERSION     XP_006720800.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720737.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..294
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..294
                     /product="proline-serine-threonine phosphatase-interacting
                     protein 1 isoform X11"
                     /calculated_mol_wt=33011
     Region          <1..135
                     /region_name="BAR"
                     /note="The Bin/Amphiphysin/Rvs (BAR) domain, a
                     dimerization module that binds membranes and detects
                     membrane curvature; cl12013"
                     /db_xref="CDD:472257"
     Region          241..293
                     /region_name="SH3_PSTPIP1"
                     /note="Src homology 3 domain of Proline-Serine-Threonine
                     Phosphatase-Interacting Protein 1; cd11824"
                     /db_xref="CDD:212758"
     Site            order(246,248,251,255,273..274,287,289..290)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212758"
     CDS             1..294
                     /gene="PSTPIP1"
                     /gene_synonym="AICZC; CD2BP1; CD2BP1L; CD2BP1S; H-PIP;
                     PAPA; PAPAS; PSTPIP"
                     /coded_by="XM_006720737.4:150..1034"
                     /db_xref="GeneID:9051"
                     /db_xref="HGNC:HGNC:9580"
                     /db_xref="MIM:606347"
ORIGIN      
        1 mdrvqkskls lykkameskk tyeqkcrdad daeqaferis anghqkqvek sqnkarqckd
       61 sateaervyr qsiaqlekvr aeweqehrtt ceafqlqefd rltilrnalw vhsnqlsmqc
      121 vkddelyeev rltlegcsid adidsfiqak stgteppapv pyqnyydrev tpltsspgiq
      181 pscgmikrfs gllhgspktt slaasaaste tltptperne gvytaiavqe iqgnpaspaq
      241 eyralydyta qnpdeldlsa gdilevileg edgwwtvern gqrgfvpgsy lekl
//
LOCUS       XP_011520471             284 aa            linear   PRI 05-AUG-2025
DEFINITION  proline-serine-threonine phosphatase-interacting protein 1 isoform
            X12 [Homo sapiens].
ACCESSION   XP_011520471
VERSION     XP_011520471.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522169.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..284
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..284
                     /product="proline-serine-threonine phosphatase-interacting
                     protein 1 isoform X12"
                     /calculated_mol_wt=33257
     Region          16..266
                     /region_name="BAR"
                     /note="The Bin/Amphiphysin/Rvs (BAR) domain, a
                     dimerization module that binds membranes and detects
                     membrane curvature; cl12013"
                     /db_xref="CDD:472257"
     Site            order(21,24..25,29,31..32,35..36,38..39,49..50,52..53,
                     56..57,59..60,63,86,89..90,232,235..236,238,240,243..244,
                     246..247,250..251,254..255,257..258,261..262,264..265)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:153355"
     CDS             1..284
                     /gene="PSTPIP1"
                     /gene_synonym="AICZC; CD2BP1; CD2BP1L; CD2BP1S; H-PIP;
                     PAPA; PAPAS; PSTPIP"
                     /coded_by="XM_011522169.2:449..1303"
                     /db_xref="GeneID:9051"
                     /db_xref="HGNC:HGNC:9580"
                     /db_xref="MIM:606347"
ORIGIN      
        1 mmpqlqfkda fwcrdftaht gyevllqrll dgrkmckdme ellrqraqae erygkelvqi
       61 arkaggqtei nslrasfdsl kqqmenvgss hiqlaltlre elrsleefre rqkeqrkkgm
      121 avprqsdcme vkspsweyea vmdrvqkskl slykkamesk ktyeqkcrda ddaeqaferi
      181 sanghqkqve ksqnkarqck dsateaervy rqsiaqlekv raeweqehrt tceafqlqef
      241 drltilrnal wvhsnqlsmq cvkddevlwt aarksqdhfv gsfc
//
LOCUS       XP_047289240             433 aa            linear   PRI 05-AUG-2025
DEFINITION  SH2 domain-containing adapter protein F isoform X1 [Homo sapiens].
ACCESSION   XP_047289240
VERSION     XP_047289240.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433284.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..433
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..433
                     /product="SH2 domain-containing adapter protein F isoform
                     X1"
                     /calculated_mol_wt=45204
     Region          386..>426
                     /region_name="SH2"
                     /note="Src homology 2 (SH2) domain; cl15255"
                     /db_xref="CDD:472789"
     CDS             1..433
                     /gene="SHF"
                     /coded_by="XM_047433284.1:16..1317"
                     /db_xref="GeneID:90525"
                     /db_xref="HGNC:HGNC:25116"
                     /db_xref="MIM:617313"
ORIGIN      
        1 mllsgappag srpgprtqgs agggpggsrr gaggagagpg gggsggvakw lrehlgfrgg
       61 ggggggskpa ppepdyrppa pspaappapp pdilaayrlq rerdfedpys ggssgsaala
      121 tpvapgptpp prhgspphrl irvetpgppa ppaderisgp passdrlail edyadpfdvq
      181 etgegsagas gapekvpend gymepyeaqk mmaeirgske tatqplplyd tpyepeedga
      241 taegegapwp resrlpedde rppeeydqpw ewkkeriska favdikvikd lpwpppvgql
      301 dsspslpdgd rdisgpaspl pepsledssa qfegpekscl spgreekgrl pprlsagnpk
      361 sakplsmeps splgewtdpa lplenqvwyh gaisrtdaen llrlckeasy lvrnsetskn
      421 dfslslncht lgv
//
LOCUS       XP_047289241             376 aa            linear   PRI 05-AUG-2025
DEFINITION  SH2 domain-containing adapter protein F isoform X2 [Homo sapiens].
ACCESSION   XP_047289241
VERSION     XP_047289241.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433285.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..376
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..376
                     /product="SH2 domain-containing adapter protein F isoform
                     X2"
                     /calculated_mol_wt=41734
     Region          274..371
                     /region_name="SH2_SHF"
                     /note="Src homology 2 domain found in SH2
                     domain-containing adapter protein F (SHF); cd10392"
                     /db_xref="CDD:198255"
     Site            order(283,301,322,324)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198255"
     Site            order(323,352)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198255"
     CDS             1..376
                     /gene="SHF"
                     /coded_by="XM_047433285.1:437..1567"
                     /db_xref="GeneID:90525"
                     /db_xref="HGNC:HGNC:25116"
                     /db_xref="MIM:617313"
ORIGIN      
        1 mqqeggpvrs apcrtgtleg srqgspghrk raspkgslss aqphswmltp splnshcahr
       61 epissspqpv angpkqkkks nwrsttrlri irlrdrlepr plailedyad pfdvqetgeg
      121 sagasgapek vpendgymep yeaqkmmaei rgsketatqp lplydtpyep eedgataege
      181 gapwpresrl pedderppee ydqpwewkke riskafaaqf egpeksclsp greekgrlpp
      241 rlsagnpksa kplsmepssp lgewtdpalp lenqvwyhga isrtdaenll rlckeasylv
      301 rnsetskndf slslkssqgf mhmklsrtke hkyvlgqnsp pfssvpeivh hyasrklpik
      361 gaehmsllyp vairtl
//
LOCUS       XP_047289242             344 aa            linear   PRI 05-AUG-2025
DEFINITION  SH2 domain-containing adapter protein F isoform X3 [Homo sapiens].
ACCESSION   XP_047289242
VERSION     XP_047289242.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433286.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..344
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..344
                     /product="SH2 domain-containing adapter protein F isoform
                     X3"
                     /calculated_mol_wt=38404
     Region          244..339
                     /region_name="SH2_SHF"
                     /note="Src homology 2 domain found in SH2
                     domain-containing adapter protein F (SHF); cd10392"
                     /db_xref="CDD:198255"
     Site            order(251,269,290,292)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198255"
     Site            order(291,320)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198255"
     CDS             1..344
                     /gene="SHF"
                     /coded_by="XM_047433286.1:437..1471"
                     /db_xref="GeneID:90525"
                     /db_xref="HGNC:HGNC:25116"
                     /db_xref="MIM:617313"
ORIGIN      
        1 mqqeggpvrs apcrtgtleg srqgspghrk raspkgslss aqphswmltp splnshcahr
       61 epissspqpv angpkqkkks nwrsttrlri irlrdrlepr plailedyad pfdvqetgeg
      121 sagasgapek vpendgymep yeaqkmmaei rgsketatqp lplydtpyep eedgataege
      181 gapwpresrl pedderppee ydqpwewkke riskafagdt hngwawtard paemppflsl
      241 ilswyhgais rtdaenllrl ckeasylvrn setskndfsl slkssqgfmh mklsrtkehk
      301 yvlgqnsppf ssvpeivhhy asrklpikga ehmsllypva irtl
//
LOCUS       XP_016878199             337 aa            linear   PRI 05-AUG-2025
DEFINITION  SH2 domain-containing adapter protein F isoform X4 [Homo sapiens].
ACCESSION   XP_016878199
VERSION     XP_016878199.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022710.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..337
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..337
                     /product="SH2 domain-containing adapter protein F isoform
                     X4"
                     /calculated_mol_wt=34575
     CDS             1..337
                     /gene="SHF"
                     /coded_by="XM_017022710.2:16..1029"
                     /db_xref="GeneID:90525"
                     /db_xref="HGNC:HGNC:25116"
                     /db_xref="MIM:617313"
ORIGIN      
        1 mllsgappag srpgprtqgs agggpggsrr gaggagagpg gggsggvakw lrehlgfrgg
       61 ggggggskpa ppepdyrppa pspaappapp pdilaayrlq rerdfedpys ggssgsaala
      121 tpvapgptpp prhgspphrl irvetpgppa ppaderisgp passdrlail edyadpfdvq
      181 etgegsagas gapekvpend gymepyeaqk mmaeirgske tatqplplyd tpyepeedga
      241 taegegapwp resrlpedde rppeeydqpw ewkkeriska favdikvikd lpwpppvgql
      301 dsspslpdgd rdisgpaspl pepsledssg aardsct
//
LOCUS       XP_011520480             326 aa            linear   PRI 05-AUG-2025
DEFINITION  SH2 domain-containing adapter protein F isoform X5 [Homo sapiens].
ACCESSION   XP_011520480
VERSION     XP_011520480.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522178.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..326
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..326
                     /product="SH2 domain-containing adapter protein F isoform
                     X5"
                     /calculated_mol_wt=33377
     CDS             1..326
                     /gene="SHF"
                     /coded_by="XM_011522178.3:16..996"
                     /db_xref="GeneID:90525"
                     /db_xref="HGNC:HGNC:25116"
                     /db_xref="MIM:617313"
ORIGIN      
        1 mllsgappag srpgprtqgs agggpggsrr gaggagagpg gggsggvakw lrehlgfrgg
       61 ggggggskpa ppepdyrppa pspaappapp pdilaayrlq rerdfedpys ggssgsaala
      121 tpvapgptpp prhgspphrl irvetpgppa ppaderisgp passdrlail edyadpfdvq
      181 etgegsagas gapekvpend gymepyeaqk mmaeirgske tatqplplyd tpyepeedga
      241 taegegapwp resrlpedde rppeeydqpw ewkkeriska faagitgpsa eptprtcsgc
      301 akrpatwcat vrparmtsps pstvil
//
LOCUS       XP_047289244             343 aa            linear   PRI 05-AUG-2025
DEFINITION  dual oxidase maturation factor 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047289244
VERSION     XP_047289244.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433288.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..343
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..343
                     /product="dual oxidase maturation factor 1 isoform X1"
                     /calculated_mol_wt=37684
     Region          10..287
                     /region_name="DuoxA"
                     /note="Dual oxidase maturation factor; pfam10204"
                     /db_xref="CDD:462995"
     CDS             1..343
                     /gene="DUOXA1"
                     /gene_synonym="mol; NIP; NUMBIP"
                     /coded_by="XM_047433288.1:175..1206"
                     /db_xref="GeneID:90527"
                     /db_xref="HGNC:HGNC:26507"
                     /db_xref="MIM:612771"
ORIGIN      
        1 matlghtfpf yagpkptfpm dttlasiimi fltalatfiv ilpgirgktr lfwllrvvts
       61 lfigaailav nfssewsvgq vstntsykaf ssewisadig lqvglggvni tltgtpvqql
      121 netinyneef twrlgenyae eyakalekgl pdpvlylaek ftprspcgly rqyrlaghyt
      181 samlwvaflc wllanvmlsm pvlvyggyml latgifqlla llffsmatsl tspcplhlga
      241 svlhthhgpa fwitlttgll cvllglamav ahrmqphrlk affnqsvded pmlewspeeg
      301 gllspryrsm adspksqdip lseasstkay ckeahpkdpd cal
//
LOCUS       XP_006720815             343 aa            linear   PRI 05-AUG-2025
DEFINITION  dual oxidase maturation factor 1 isoform X1 [Homo sapiens].
ACCESSION   XP_006720815
VERSION     XP_006720815.3
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720752.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XP_006720815.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..343
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..343
                     /product="dual oxidase maturation factor 1 isoform X1"
                     /calculated_mol_wt=37684
     Region          10..287
                     /region_name="DuoxA"
                     /note="Dual oxidase maturation factor; pfam10204"
                     /db_xref="CDD:462995"
     CDS             1..343
                     /gene="DUOXA1"
                     /gene_synonym="mol; NIP; NUMBIP"
                     /coded_by="XM_006720752.4:58..1089"
                     /db_xref="GeneID:90527"
                     /db_xref="HGNC:HGNC:26507"
                     /db_xref="MIM:612771"
ORIGIN      
        1 matlghtfpf yagpkptfpm dttlasiimi fltalatfiv ilpgirgktr lfwllrvvts
       61 lfigaailav nfssewsvgq vstntsykaf ssewisadig lqvglggvni tltgtpvqql
      121 netinyneef twrlgenyae eyakalekgl pdpvlylaek ftprspcgly rqyrlaghyt
      181 samlwvaflc wllanvmlsm pvlvyggyml latgifqlla llffsmatsl tspcplhlga
      241 svlhthhgpa fwitlttgll cvllglamav ahrmqphrlk affnqsvded pmlewspeeg
      301 gllspryrsm adspksqdip lseasstkay ckeahpkdpd cal
//
LOCUS       XP_047289245             298 aa            linear   PRI 05-AUG-2025
DEFINITION  dual oxidase maturation factor 1 isoform X2 [Homo sapiens].
ACCESSION   XP_047289245
VERSION     XP_047289245.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433289.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..298
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..298
                     /product="dual oxidase maturation factor 1 isoform X2"
                     /calculated_mol_wt=32980
     Region          10..242
                     /region_name="DuoxA"
                     /note="Dual oxidase maturation factor; pfam10204"
                     /db_xref="CDD:462995"
     CDS             1..298
                     /gene="DUOXA1"
                     /gene_synonym="mol; NIP; NUMBIP"
                     /coded_by="XM_047433289.1:175..1071"
                     /db_xref="GeneID:90527"
                     /db_xref="HGNC:HGNC:26507"
                     /db_xref="MIM:612771"
ORIGIN      
        1 matlghtfpf yagpkptfpm dttlasiimi fltalatfiv ilpgirgktr lfwllrvvts
       61 lfigaailgt pvqqlnetin yneeftwrlg enyaeeyaka lekglpdpvl ylaekftprs
      121 pcglyrqyrl aghytsamlw vaflcwllan vmlsmpvlvy ggymllatgi fqllallffs
      181 matsltspcp lhlgasvlht hhgpafwitl ttgllcvllg lamavahrmq phrlkaffnq
      241 svdedpmlew speeggllsp ryrsmadspk sqdiplseas stkayckeah pkdpdcal
//
LOCUS       XP_006720806             343 aa            linear   PRI 05-AUG-2025
DEFINITION  dual oxidase maturation factor 1 isoform X1 [Homo sapiens].
ACCESSION   XP_006720806
VERSION     XP_006720806.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720743.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..343
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..343
                     /product="dual oxidase maturation factor 1 isoform X1"
                     /calculated_mol_wt=37684
     Region          10..287
                     /region_name="DuoxA"
                     /note="Dual oxidase maturation factor; pfam10204"
                     /db_xref="CDD:462995"
     CDS             1..343
                     /gene="DUOXA1"
                     /gene_synonym="mol; NIP; NUMBIP"
                     /coded_by="XM_006720743.4:675..1706"
                     /db_xref="GeneID:90527"
                     /db_xref="HGNC:HGNC:26507"
                     /db_xref="MIM:612771"
ORIGIN      
        1 matlghtfpf yagpkptfpm dttlasiimi fltalatfiv ilpgirgktr lfwllrvvts
       61 lfigaailav nfssewsvgq vstntsykaf ssewisadig lqvglggvni tltgtpvqql
      121 netinyneef twrlgenyae eyakalekgl pdpvlylaek ftprspcgly rqyrlaghyt
      181 samlwvaflc wllanvmlsm pvlvyggyml latgifqlla llffsmatsl tspcplhlga
      241 svlhthhgpa fwitlttgll cvllglamav ahrmqphrlk affnqsvded pmlewspeeg
      301 gllspryrsm adspksqdip lseasstkay ckeahpkdpd cal
//
LOCUS       XP_047289246             343 aa            linear   PRI 05-AUG-2025
DEFINITION  dual oxidase maturation factor 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047289246
VERSION     XP_047289246.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433290.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..343
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..343
                     /product="dual oxidase maturation factor 1 isoform X1"
                     /calculated_mol_wt=37684
     Region          10..287
                     /region_name="DuoxA"
                     /note="Dual oxidase maturation factor; pfam10204"
                     /db_xref="CDD:462995"
     CDS             1..343
                     /gene="DUOXA1"
                     /gene_synonym="mol; NIP; NUMBIP"
                     /coded_by="XM_047433290.1:772..1803"
                     /db_xref="GeneID:90527"
                     /db_xref="HGNC:HGNC:26507"
                     /db_xref="MIM:612771"
ORIGIN      
        1 matlghtfpf yagpkptfpm dttlasiimi fltalatfiv ilpgirgktr lfwllrvvts
       61 lfigaailav nfssewsvgq vstntsykaf ssewisadig lqvglggvni tltgtpvqql
      121 netinyneef twrlgenyae eyakalekgl pdpvlylaek ftprspcgly rqyrlaghyt
      181 samlwvaflc wllanvmlsm pvlvyggyml latgifqlla llffsmatsl tspcplhlga
      241 svlhthhgpa fwitlttgll cvllglamav ahrmqphrlk affnqsvded pmlewspeeg
      301 gllspryrsm adspksqdip lseasstkay ckeahpkdpd cal
//
LOCUS       XP_047289248             343 aa            linear   PRI 05-AUG-2025
DEFINITION  dual oxidase maturation factor 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047289248
VERSION     XP_047289248.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433292.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..343
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..343
                     /product="dual oxidase maturation factor 1 isoform X1"
                     /calculated_mol_wt=37684
     Region          10..287
                     /region_name="DuoxA"
                     /note="Dual oxidase maturation factor; pfam10204"
                     /db_xref="CDD:462995"
     CDS             1..343
                     /gene="DUOXA1"
                     /gene_synonym="mol; NIP; NUMBIP"
                     /coded_by="XM_047433292.1:413..1444"
                     /db_xref="GeneID:90527"
                     /db_xref="HGNC:HGNC:26507"
                     /db_xref="MIM:612771"
ORIGIN      
        1 matlghtfpf yagpkptfpm dttlasiimi fltalatfiv ilpgirgktr lfwllrvvts
       61 lfigaailav nfssewsvgq vstntsykaf ssewisadig lqvglggvni tltgtpvqql
      121 netinyneef twrlgenyae eyakalekgl pdpvlylaek ftprspcgly rqyrlaghyt
      181 samlwvaflc wllanvmlsm pvlvyggyml latgifqlla llffsmatsl tspcplhlga
      241 svlhthhgpa fwitlttgll cvllglamav ahrmqphrlk affnqsvded pmlewspeeg
      301 gllspryrsm adspksqdip lseasstkay ckeahpkdpd cal
//
LOCUS       XP_006720808             343 aa            linear   PRI 05-AUG-2025
DEFINITION  dual oxidase maturation factor 1 isoform X1 [Homo sapiens].
ACCESSION   XP_006720808
VERSION     XP_006720808.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720745.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..343
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..343
                     /product="dual oxidase maturation factor 1 isoform X1"
                     /calculated_mol_wt=37684
     Region          10..287
                     /region_name="DuoxA"
                     /note="Dual oxidase maturation factor; pfam10204"
                     /db_xref="CDD:462995"
     CDS             1..343
                     /gene="DUOXA1"
                     /gene_synonym="mol; NIP; NUMBIP"
                     /coded_by="XM_006720745.2:565..1596"
                     /db_xref="GeneID:90527"
                     /db_xref="HGNC:HGNC:26507"
                     /db_xref="MIM:612771"
ORIGIN      
        1 matlghtfpf yagpkptfpm dttlasiimi fltalatfiv ilpgirgktr lfwllrvvts
       61 lfigaailav nfssewsvgq vstntsykaf ssewisadig lqvglggvni tltgtpvqql
      121 netinyneef twrlgenyae eyakalekgl pdpvlylaek ftprspcgly rqyrlaghyt
      181 samlwvaflc wllanvmlsm pvlvyggyml latgifqlla llffsmatsl tspcplhlga
      241 svlhthhgpa fwitlttgll cvllglamav ahrmqphrlk affnqsvded pmlewspeeg
      301 gllspryrsm adspksqdip lseasstkay ckeahpkdpd cal
//
LOCUS       XP_006720809             343 aa            linear   PRI 05-AUG-2025
DEFINITION  dual oxidase maturation factor 1 isoform X1 [Homo sapiens].
ACCESSION   XP_006720809
VERSION     XP_006720809.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720746.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..343
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..343
                     /product="dual oxidase maturation factor 1 isoform X1"
                     /calculated_mol_wt=37684
     Region          10..287
                     /region_name="DuoxA"
                     /note="Dual oxidase maturation factor; pfam10204"
                     /db_xref="CDD:462995"
     CDS             1..343
                     /gene="DUOXA1"
                     /gene_synonym="mol; NIP; NUMBIP"
                     /coded_by="XM_006720746.2:536..1567"
                     /db_xref="GeneID:90527"
                     /db_xref="HGNC:HGNC:26507"
                     /db_xref="MIM:612771"
ORIGIN      
        1 matlghtfpf yagpkptfpm dttlasiimi fltalatfiv ilpgirgktr lfwllrvvts
       61 lfigaailav nfssewsvgq vstntsykaf ssewisadig lqvglggvni tltgtpvqql
      121 netinyneef twrlgenyae eyakalekgl pdpvlylaek ftprspcgly rqyrlaghyt
      181 samlwvaflc wllanvmlsm pvlvyggyml latgifqlla llffsmatsl tspcplhlga
      241 svlhthhgpa fwitlttgll cvllglamav ahrmqphrlk affnqsvded pmlewspeeg
      301 gllspryrsm adspksqdip lseasstkay ckeahpkdpd cal
//
LOCUS       XP_011520483             343 aa            linear   PRI 05-AUG-2025
DEFINITION  dual oxidase maturation factor 1 isoform X1 [Homo sapiens].
ACCESSION   XP_011520483
VERSION     XP_011520483.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522181.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..343
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..343
                     /product="dual oxidase maturation factor 1 isoform X1"
                     /calculated_mol_wt=37684
     Region          10..287
                     /region_name="DuoxA"
                     /note="Dual oxidase maturation factor; pfam10204"
                     /db_xref="CDD:462995"
     CDS             1..343
                     /gene="DUOXA1"
                     /gene_synonym="mol; NIP; NUMBIP"
                     /coded_by="XM_011522181.3:703..1734"
                     /db_xref="GeneID:90527"
                     /db_xref="HGNC:HGNC:26507"
                     /db_xref="MIM:612771"
ORIGIN      
        1 matlghtfpf yagpkptfpm dttlasiimi fltalatfiv ilpgirgktr lfwllrvvts
       61 lfigaailav nfssewsvgq vstntsykaf ssewisadig lqvglggvni tltgtpvqql
      121 netinyneef twrlgenyae eyakalekgl pdpvlylaek ftprspcgly rqyrlaghyt
      181 samlwvaflc wllanvmlsm pvlvyggyml latgifqlla llffsmatsl tspcplhlga
      241 svlhthhgpa fwitlttgll cvllglamav ahrmqphrlk affnqsvded pmlewspeeg
      301 gllspryrsm adspksqdip lseasstkay ckeahpkdpd cal
//
LOCUS       XP_047289249             343 aa            linear   PRI 05-AUG-2025
DEFINITION  dual oxidase maturation factor 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047289249
VERSION     XP_047289249.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433293.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..343
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..343
                     /product="dual oxidase maturation factor 1 isoform X1"
                     /calculated_mol_wt=37684
     Region          10..287
                     /region_name="DuoxA"
                     /note="Dual oxidase maturation factor; pfam10204"
                     /db_xref="CDD:462995"
     CDS             1..343
                     /gene="DUOXA1"
                     /gene_synonym="mol; NIP; NUMBIP"
                     /coded_by="XM_047433293.1:567..1598"
                     /db_xref="GeneID:90527"
                     /db_xref="HGNC:HGNC:26507"
                     /db_xref="MIM:612771"
ORIGIN      
        1 matlghtfpf yagpkptfpm dttlasiimi fltalatfiv ilpgirgktr lfwllrvvts
       61 lfigaailav nfssewsvgq vstntsykaf ssewisadig lqvglggvni tltgtpvqql
      121 netinyneef twrlgenyae eyakalekgl pdpvlylaek ftprspcgly rqyrlaghyt
      181 samlwvaflc wllanvmlsm pvlvyggyml latgifqlla llffsmatsl tspcplhlga
      241 svlhthhgpa fwitlttgll cvllglamav ahrmqphrlk affnqsvded pmlewspeeg
      301 gllspryrsm adspksqdip lseasstkay ckeahpkdpd cal
//
LOCUS       XP_006720810             343 aa            linear   PRI 05-AUG-2025
DEFINITION  dual oxidase maturation factor 1 isoform X1 [Homo sapiens].
ACCESSION   XP_006720810
VERSION     XP_006720810.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720747.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..343
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..343
                     /product="dual oxidase maturation factor 1 isoform X1"
                     /calculated_mol_wt=37684
     Region          10..287
                     /region_name="DuoxA"
                     /note="Dual oxidase maturation factor; pfam10204"
                     /db_xref="CDD:462995"
     CDS             1..343
                     /gene="DUOXA1"
                     /gene_synonym="mol; NIP; NUMBIP"
                     /coded_by="XM_006720747.4:586..1617"
                     /db_xref="GeneID:90527"
                     /db_xref="HGNC:HGNC:26507"
                     /db_xref="MIM:612771"
ORIGIN      
        1 matlghtfpf yagpkptfpm dttlasiimi fltalatfiv ilpgirgktr lfwllrvvts
       61 lfigaailav nfssewsvgq vstntsykaf ssewisadig lqvglggvni tltgtpvqql
      121 netinyneef twrlgenyae eyakalekgl pdpvlylaek ftprspcgly rqyrlaghyt
      181 samlwvaflc wllanvmlsm pvlvyggyml latgifqlla llffsmatsl tspcplhlga
      241 svlhthhgpa fwitlttgll cvllglamav ahrmqphrlk affnqsvded pmlewspeeg
      301 gllspryrsm adspksqdip lseasstkay ckeahpkdpd cal
//
LOCUS       XP_006720814             343 aa            linear   PRI 05-AUG-2025
DEFINITION  dual oxidase maturation factor 1 isoform X1 [Homo sapiens].
ACCESSION   XP_006720814
VERSION     XP_006720814.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720751.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..343
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..343
                     /product="dual oxidase maturation factor 1 isoform X1"
                     /calculated_mol_wt=37684
     Region          10..287
                     /region_name="DuoxA"
                     /note="Dual oxidase maturation factor; pfam10204"
                     /db_xref="CDD:462995"
     CDS             1..343
                     /gene="DUOXA1"
                     /gene_synonym="mol; NIP; NUMBIP"
                     /coded_by="XM_006720751.4:87..1118"
                     /db_xref="GeneID:90527"
                     /db_xref="HGNC:HGNC:26507"
                     /db_xref="MIM:612771"
ORIGIN      
        1 matlghtfpf yagpkptfpm dttlasiimi fltalatfiv ilpgirgktr lfwllrvvts
       61 lfigaailav nfssewsvgq vstntsykaf ssewisadig lqvglggvni tltgtpvqql
      121 netinyneef twrlgenyae eyakalekgl pdpvlylaek ftprspcgly rqyrlaghyt
      181 samlwvaflc wllanvmlsm pvlvyggyml latgifqlla llffsmatsl tspcplhlga
      241 svlhthhgpa fwitlttgll cvllglamav ahrmqphrlk affnqsvded pmlewspeeg
      301 gllspryrsm adspksqdip lseasstkay ckeahpkdpd cal
//
LOCUS       XP_011520485             343 aa            linear   PRI 05-AUG-2025
DEFINITION  dual oxidase maturation factor 1 isoform X1 [Homo sapiens].
ACCESSION   XP_011520485
VERSION     XP_011520485.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522183.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..343
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..343
                     /product="dual oxidase maturation factor 1 isoform X1"
                     /calculated_mol_wt=37684
     Region          10..287
                     /region_name="DuoxA"
                     /note="Dual oxidase maturation factor; pfam10204"
                     /db_xref="CDD:462995"
     CDS             1..343
                     /gene="DUOXA1"
                     /gene_synonym="mol; NIP; NUMBIP"
                     /coded_by="XM_011522183.3:439..1470"
                     /db_xref="GeneID:90527"
                     /db_xref="HGNC:HGNC:26507"
                     /db_xref="MIM:612771"
ORIGIN      
        1 matlghtfpf yagpkptfpm dttlasiimi fltalatfiv ilpgirgktr lfwllrvvts
       61 lfigaailav nfssewsvgq vstntsykaf ssewisadig lqvglggvni tltgtpvqql
      121 netinyneef twrlgenyae eyakalekgl pdpvlylaek ftprspcgly rqyrlaghyt
      181 samlwvaflc wllanvmlsm pvlvyggyml latgifqlla llffsmatsl tspcplhlga
      241 svlhthhgpa fwitlttgll cvllglamav ahrmqphrlk affnqsvded pmlewspeeg
      301 gllspryrsm adspksqdip lseasstkay ckeahpkdpd cal
//
LOCUS       XP_011520488             186 aa            linear   PRI 05-AUG-2025
DEFINITION  dual oxidase maturation factor 1 isoform X3 [Homo sapiens].
ACCESSION   XP_011520488
VERSION     XP_011520488.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522186.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..186
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..186
                     /product="dual oxidase maturation factor 1 isoform X3"
                     /calculated_mol_wt=20487
     Region          10..>184
                     /region_name="DuoxA"
                     /note="Dual oxidase maturation factor; pfam10204"
                     /db_xref="CDD:462995"
     CDS             1..186
                     /gene="DUOXA1"
                     /gene_synonym="mol; NIP; NUMBIP"
                     /coded_by="XM_011522186.3:175..735"
                     /db_xref="GeneID:90527"
                     /db_xref="HGNC:HGNC:26507"
                     /db_xref="MIM:612771"
ORIGIN      
        1 matlghtfpf yagpkptfpm dttlasiimi fltalatfiv ilpgirgktr lfwllrvvts
       61 lfigaailav nfssewsvgq vstntsykaf ssewisadig lqvglggvni tltgtpvqql
      121 netinyneef twrlgenyae eyakalekgl pdpvlylaek ftprspcgly rqyrlaghyt
      181 samlcr
//
LOCUS       XP_011520489             621 aa            linear   PRI 05-AUG-2025
DEFINITION  protein regulator of cytokinesis 1 isoform X1 [Homo sapiens].
ACCESSION   XP_011520489
VERSION     XP_011520489.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522187.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..621
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..621
                     /product="protein regulator of cytokinesis 1 isoform X1"
                     /calculated_mol_wt=71873
     Region          16..477
                     /region_name="MAP65_ASE1"
                     /note="Microtubule associated protein (MAP65/ASE1 family);
                     pfam03999"
                     /db_xref="CDD:427641"
     CDS             1..621
                     /gene="PRC1"
                     /gene_synonym="ASE1; MAP65"
                     /coded_by="XM_011522187.3:119..1984"
                     /db_xref="GeneID:9055"
                     /db_xref="HGNC:HGNC:9341"
                     /db_xref="MIM:603484"
ORIGIN      
        1 mrrsevlaee sivclqkaln hlreiwelig ipedqrlqrt evvkkhikel ldmmiaeees
       61 lkerliksis vcqkelntlc selhvepfqe egettilqle kdlrtqvelm rkqkkerkqe
      121 lkllqeqdqe lceilcmphy didsasvpsl eelnqfrqhv ttlretkasr reefvsikrq
      181 iilcmealdh tpdtsferdv vcededafcl sleniatlqk llrqlemqks qneavceglr
      241 tqirelwdrl qipeeereav atimsgskak vrkalqlevd rleelkmqnm kkvieairve
      301 lvqywdqcfy sqeqrqafap fcaedytesl lqlhdaeivr lknyyevhke lfegvqkwee
      361 twrlflefer kasdpnrftn rggnllkeek qraklqkmlp kleeelkari elweqehska
      421 fmvngqkfme yvaeqwemhr lekerakqer qlknkkqtet emlygsaprt pskrrglapn
      481 tpgkarklnt ttmsnatans sirpifggtv yhspvsrlpp sgskpvaast csgkktprtg
      541 rhgankenle lngsilsggy pgsaplqrnf sinsvastys efakdpslsd sstvglqdsl
      601 ppeenvfvcp klrwpallpk r
//
LOCUS       XP_011520490             607 aa            linear   PRI 05-AUG-2025
DEFINITION  protein regulator of cytokinesis 1 isoform X2 [Homo sapiens].
ACCESSION   XP_011520490
VERSION     XP_011520490.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522188.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..607
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..607
                     /product="protein regulator of cytokinesis 1 isoform X2"
                     /calculated_mol_wt=70458
     Region          16..477
                     /region_name="MAP65_ASE1"
                     /note="Microtubule associated protein (MAP65/ASE1 family);
                     pfam03999"
                     /db_xref="CDD:427641"
     CDS             1..607
                     /gene="PRC1"
                     /gene_synonym="ASE1; MAP65"
                     /coded_by="XM_011522188.4:119..1942"
                     /db_xref="GeneID:9055"
                     /db_xref="HGNC:HGNC:9341"
                     /db_xref="MIM:603484"
ORIGIN      
        1 mrrsevlaee sivclqkaln hlreiwelig ipedqrlqrt evvkkhikel ldmmiaeees
       61 lkerliksis vcqkelntlc selhvepfqe egettilqle kdlrtqvelm rkqkkerkqe
      121 lkllqeqdqe lceilcmphy didsasvpsl eelnqfrqhv ttlretkasr reefvsikrq
      181 iilcmealdh tpdtsferdv vcededafcl sleniatlqk llrqlemqks qneavceglr
      241 tqirelwdrl qipeeereav atimsgskak vrkalqlevd rleelkmqnm kkvieairve
      301 lvqywdqcfy sqeqrqafap fcaedytesl lqlhdaeivr lknyyevhke lfegvqkwee
      361 twrlflefer kasdpnrftn rggnllkeek qraklqkmlp kleeelkari elweqehska
      421 fmvngqkfme yvaeqwemhr lekerakqer qlknkkqtet emlygsaprt pskrrglapn
      481 tpgkarklnt ttmsnatans sirpifggtv yhspvsrlpp sgskpvaast csgkktprtg
      541 rhgankenle lngsilsggy pgsaplqrnf sinsvastys efadslppee nvfvcpklrw
      601 pallpkr
//
LOCUS       XP_011520491             584 aa            linear   PRI 05-AUG-2025
DEFINITION  protein regulator of cytokinesis 1 isoform X3 [Homo sapiens].
ACCESSION   XP_011520491
VERSION     XP_011520491.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522189.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..584
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..584
                     /product="protein regulator of cytokinesis 1 isoform X3"
                     /calculated_mol_wt=68044
     Region          16..477
                     /region_name="MAP65_ASE1"
                     /note="Microtubule associated protein (MAP65/ASE1 family);
                     pfam03999"
                     /db_xref="CDD:427641"
     CDS             1..584
                     /gene="PRC1"
                     /gene_synonym="ASE1; MAP65"
                     /coded_by="XM_011522189.3:119..1873"
                     /db_xref="GeneID:9055"
                     /db_xref="HGNC:HGNC:9341"
                     /db_xref="MIM:603484"
ORIGIN      
        1 mrrsevlaee sivclqkaln hlreiwelig ipedqrlqrt evvkkhikel ldmmiaeees
       61 lkerliksis vcqkelntlc selhvepfqe egettilqle kdlrtqvelm rkqkkerkqe
      121 lkllqeqdqe lceilcmphy didsasvpsl eelnqfrqhv ttlretkasr reefvsikrq
      181 iilcmealdh tpdtsferdv vcededafcl sleniatlqk llrqlemqks qneavceglr
      241 tqirelwdrl qipeeereav atimsgskak vrkalqlevd rleelkmqnm kkvieairve
      301 lvqywdqcfy sqeqrqafap fcaedytesl lqlhdaeivr lknyyevhke lfegvqkwee
      361 twrlflefer kasdpnrftn rggnllkeek qraklqkmlp kleeelkari elweqehska
      421 fmvngqkfme yvaeqwemhr lekerakqer qlknkkqtet emlygsaprt pskrrglapn
      481 tpgkarkpva astcsgkktp rtgrhganke nlelngsils ggypgsaplq rnfsinsvas
      541 tysefakdps lsdsstvglq dslppeenvf vcpklrwpal lpkr
//
LOCUS       XP_016878201             583 aa            linear   PRI 05-AUG-2025
DEFINITION  protein regulator of cytokinesis 1 isoform X4 [Homo sapiens].
ACCESSION   XP_016878201
VERSION     XP_016878201.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022712.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..583
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..583
                     /product="protein regulator of cytokinesis 1 isoform X4"
                     /calculated_mol_wt=67646
     Region          16..477
                     /region_name="MAP65_ASE1"
                     /note="Microtubule associated protein (MAP65/ASE1 family);
                     pfam03999"
                     /db_xref="CDD:427641"
     CDS             1..583
                     /gene="PRC1"
                     /gene_synonym="ASE1; MAP65"
                     /coded_by="XM_017022712.3:119..1870"
                     /db_xref="GeneID:9055"
                     /db_xref="HGNC:HGNC:9341"
                     /db_xref="MIM:603484"
ORIGIN      
        1 mrrsevlaee sivclqkaln hlreiwelig ipedqrlqrt evvkkhikel ldmmiaeees
       61 lkerliksis vcqkelntlc selhvepfqe egettilqle kdlrtqvelm rkqkkerkqe
      121 lkllqeqdqe lceilcmphy didsasvpsl eelnqfrqhv ttlretkasr reefvsikrq
      181 iilcmealdh tpdtsferdv vcededafcl sleniatlqk llrqlemqks qneavceglr
      241 tqirelwdrl qipeeereav atimsgskak vrkalqlevd rleelkmqnm kkvieairve
      301 lvqywdqcfy sqeqrqafap fcaedytesl lqlhdaeivr lknyyevhke lfegvqkwee
      361 twrlflefer kasdpnrftn rggnllkeek qraklqkmlp kleeelkari elweqehska
      421 fmvngqkfme yvaeqwemhr lekerakqer qlknkkqtet emlygsaprt pskrrglapn
      481 tpgkarkpva astcsgkktp rtgrhganke nlelngsils ggypgsaplq rnfsinsvas
      541 tysefakdps lsdsstvglq relskasksd atsgilnstn iqs
//
LOCUS       XP_047289251             570 aa            linear   PRI 05-AUG-2025
DEFINITION  protein regulator of cytokinesis 1 isoform X5 [Homo sapiens].
ACCESSION   XP_047289251
VERSION     XP_047289251.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433295.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..570
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..570
                     /product="protein regulator of cytokinesis 1 isoform X5"
                     /calculated_mol_wt=66629
     Region          16..477
                     /region_name="MAP65_ASE1"
                     /note="Microtubule associated protein (MAP65/ASE1 family);
                     pfam03999"
                     /db_xref="CDD:427641"
     CDS             1..570
                     /gene="PRC1"
                     /gene_synonym="ASE1; MAP65"
                     /coded_by="XM_047433295.1:119..1831"
                     /db_xref="GeneID:9055"
                     /db_xref="HGNC:HGNC:9341"
                     /db_xref="MIM:603484"
ORIGIN      
        1 mrrsevlaee sivclqkaln hlreiwelig ipedqrlqrt evvkkhikel ldmmiaeees
       61 lkerliksis vcqkelntlc selhvepfqe egettilqle kdlrtqvelm rkqkkerkqe
      121 lkllqeqdqe lceilcmphy didsasvpsl eelnqfrqhv ttlretkasr reefvsikrq
      181 iilcmealdh tpdtsferdv vcededafcl sleniatlqk llrqlemqks qneavceglr
      241 tqirelwdrl qipeeereav atimsgskak vrkalqlevd rleelkmqnm kkvieairve
      301 lvqywdqcfy sqeqrqafap fcaedytesl lqlhdaeivr lknyyevhke lfegvqkwee
      361 twrlflefer kasdpnrftn rggnllkeek qraklqkmlp kleeelkari elweqehska
      421 fmvngqkfme yvaeqwemhr lekerakqer qlknkkqtet emlygsaprt pskrrglapn
      481 tpgkarkpva astcsgkktp rtgrhganke nlelngsils ggypgsaplq rnfsinsvas
      541 tysefadslp peenvfvcpk lrwpallpkr
//
LOCUS       XP_016878202             569 aa            linear   PRI 05-AUG-2025
DEFINITION  protein regulator of cytokinesis 1 isoform X6 [Homo sapiens].
ACCESSION   XP_016878202
VERSION     XP_016878202.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022713.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..569
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..569
                     /product="protein regulator of cytokinesis 1 isoform X6"
                     /calculated_mol_wt=66231
     Region          16..477
                     /region_name="MAP65_ASE1"
                     /note="Microtubule associated protein (MAP65/ASE1 family);
                     pfam03999"
                     /db_xref="CDD:427641"
     CDS             1..569
                     /gene="PRC1"
                     /gene_synonym="ASE1; MAP65"
                     /coded_by="XM_017022713.3:119..1828"
                     /db_xref="GeneID:9055"
                     /db_xref="HGNC:HGNC:9341"
                     /db_xref="MIM:603484"
ORIGIN      
        1 mrrsevlaee sivclqkaln hlreiwelig ipedqrlqrt evvkkhikel ldmmiaeees
       61 lkerliksis vcqkelntlc selhvepfqe egettilqle kdlrtqvelm rkqkkerkqe
      121 lkllqeqdqe lceilcmphy didsasvpsl eelnqfrqhv ttlretkasr reefvsikrq
      181 iilcmealdh tpdtsferdv vcededafcl sleniatlqk llrqlemqks qneavceglr
      241 tqirelwdrl qipeeereav atimsgskak vrkalqlevd rleelkmqnm kkvieairve
      301 lvqywdqcfy sqeqrqafap fcaedytesl lqlhdaeivr lknyyevhke lfegvqkwee
      361 twrlflefer kasdpnrftn rggnllkeek qraklqkmlp kleeelkari elweqehska
      421 fmvngqkfme yvaeqwemhr lekerakqer qlknkkqtet emlygsaprt pskrrglapn
      481 tpgkarkpva astcsgkktp rtgrhganke nlelngsils ggypgsaplq rnfsinsvas
      541 tysefarels kasksdatsg ilnstniqs
//
LOCUS       XP_016878203             569 aa            linear   PRI 05-AUG-2025
DEFINITION  protein regulator of cytokinesis 1 isoform X7 [Homo sapiens].
ACCESSION   XP_016878203
VERSION     XP_016878203.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022714.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..569
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..569
                     /product="protein regulator of cytokinesis 1 isoform X7"
                     /calculated_mol_wt=65684
     Region          1..425
                     /region_name="MAP65_ASE1"
                     /note="Microtubule associated protein (MAP65/ASE1 family);
                     pfam03999"
                     /db_xref="CDD:427641"
     CDS             1..569
                     /gene="PRC1"
                     /gene_synonym="ASE1; MAP65"
                     /coded_by="XM_017022714.3:142..1851"
                     /db_xref="GeneID:9055"
                     /db_xref="HGNC:HGNC:9341"
                     /db_xref="MIM:603484"
ORIGIN      
        1 mmiaeeeslk erliksisvc qkelntlcse lhvepfqeeg ettilqlekd lrtqvelmrk
       61 qkkerkqelk llqeqdqelc eilcmphydi dsasvpslee lnqfrqhvtt lretkasrre
      121 efvsikrqii lcmealdhtp dtsferdvvc ededafclsl eniatlqkll rqlemqksqn
      181 eavceglrtq irelwdrlqi peeereavat imsgskakvr kalqlevdrl eelkmqnmkk
      241 vieairvelv qywdqcfysq eqrqafapfc aedytesllq lhdaeivrlk nyyevhkelf
      301 egvqkweetw rlfleferka sdpnrftnrg gnllkeekqr aklqkmlpkl eeelkariel
      361 weqehskafm vngqkfmeyv aeqwemhrle kerakqerql knkkqtetem lygsaprtps
      421 krrglapntp gkarklnttt msnatanssi rpifggtvyh spvsrlppsg skpvaastcs
      481 gkktprtgrh gankenleln gsilsggypg saplqrnfsi nsvastysef akdpslsdss
      541 tvglqdslpp eenvfvcpkl rwpallpkr
//
LOCUS       XP_005255044             566 aa            linear   PRI 05-AUG-2025
DEFINITION  protein regulator of cytokinesis 1 isoform X8 [Homo sapiens].
ACCESSION   XP_005255044
VERSION     XP_005255044.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254987.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..566
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..566
                     /product="protein regulator of cytokinesis 1 isoform X8"
                     /calculated_mol_wt=66017
     Region          16..477
                     /region_name="MAP65_ASE1"
                     /note="Microtubule associated protein (MAP65/ASE1 family);
                     pfam03999"
                     /db_xref="CDD:427641"
     CDS             1..566
                     /gene="PRC1"
                     /gene_synonym="ASE1; MAP65"
                     /coded_by="XM_005254987.4:119..1819"
                     /db_xref="GeneID:9055"
                     /db_xref="HGNC:HGNC:9341"
                     /db_xref="MIM:603484"
ORIGIN      
        1 mrrsevlaee sivclqkaln hlreiwelig ipedqrlqrt evvkkhikel ldmmiaeees
       61 lkerliksis vcqkelntlc selhvepfqe egettilqle kdlrtqvelm rkqkkerkqe
      121 lkllqeqdqe lceilcmphy didsasvpsl eelnqfrqhv ttlretkasr reefvsikrq
      181 iilcmealdh tpdtsferdv vcededafcl sleniatlqk llrqlemqks qneavceglr
      241 tqirelwdrl qipeeereav atimsgskak vrkalqlevd rleelkmqnm kkvieairve
      301 lvqywdqcfy sqeqrqafap fcaedytesl lqlhdaeivr lknyyevhke lfegvqkwee
      361 twrlflefer kasdpnrftn rggnllkeek qraklqkmlp kleeelkari elweqehska
      421 fmvngqkfme yvaeqwemhr lekerakqer qlknkkqtet emlygsaprt pskrrglapn
      481 tpgkarklnt ttmsnatans sirpifggtv yhspvsrlpp sgskpvaast csgkktprtg
      541 rhgankenle lngsilsart fkgfqi
//
LOCUS       XP_011520492             564 aa            linear   PRI 05-AUG-2025
DEFINITION  protein regulator of cytokinesis 1 isoform X9 [Homo sapiens].
ACCESSION   XP_011520492
VERSION     XP_011520492.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522190.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..564
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..564
                     /product="protein regulator of cytokinesis 1 isoform X9"
                     /calculated_mol_wt=65264
     Region          16..420
                     /region_name="MAP65_ASE1"
                     /note="Microtubule associated protein (MAP65/ASE1 family);
                     pfam03999"
                     /db_xref="CDD:427641"
     CDS             1..564
                     /gene="PRC1"
                     /gene_synonym="ASE1; MAP65"
                     /coded_by="XM_011522190.4:119..1813"
                     /db_xref="GeneID:9055"
                     /db_xref="HGNC:HGNC:9341"
                     /db_xref="MIM:603484"
ORIGIN      
        1 mrrsevlaee sivclqkaln hlreiwelig ipedqrlqrt evvkkhikel ldmmiaeees
       61 lkerliksis vcqkelntlc selhvepfqe egettilqle kdlrtqvelm rkqkkerkqe
      121 lkllqeqdqe lceilcmphy didsasvpsl eelnqfrqhv ttlretklem qksqneavce
      181 glrtqirelw drlqipeeer eavatimsgs kakvrkalql evdrleelkm qnmkkvieai
      241 rvelvqywdq cfysqeqrqa fapfcaedyt esllqlhdae ivrlknyyev hkelfegvqk
      301 weetwrlfle ferkasdpnr ftnrggnllk eekqraklqk mlpkleeelk arielweqeh
      361 skafmvngqk fmeyvaeqwe mhrlekerak qerqlknkkq tetemlygsa prtpskrrgl
      421 apntpgkark lntttmsnat anssirpifg gtvyhspvsr lppsgskpva astcsgkktp
      481 rtgrhganke nlelngsils ggypgsaplq rnfsinsvas tysefakdps lsdsstvglq
      541 dslppeenvf vcpklrwpal lpkr
//
LOCUS       XP_011520493             563 aa            linear   PRI 05-AUG-2025
DEFINITION  protein regulator of cytokinesis 1 isoform X10 [Homo sapiens].
ACCESSION   XP_011520493
VERSION     XP_011520493.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522191.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..563
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..563
                     /product="protein regulator of cytokinesis 1 isoform X10"
                     /calculated_mol_wt=65550
     Region          16..477
                     /region_name="MAP65_ASE1"
                     /note="Microtubule associated protein (MAP65/ASE1 family);
                     pfam03999"
                     /db_xref="CDD:427641"
     CDS             1..563
                     /gene="PRC1"
                     /gene_synonym="ASE1; MAP65"
                     /coded_by="XM_011522191.4:119..1810"
                     /db_xref="GeneID:9055"
                     /db_xref="HGNC:HGNC:9341"
                     /db_xref="MIM:603484"
ORIGIN      
        1 mrrsevlaee sivclqkaln hlreiwelig ipedqrlqrt evvkkhikel ldmmiaeees
       61 lkerliksis vcqkelntlc selhvepfqe egettilqle kdlrtqvelm rkqkkerkqe
      121 lkllqeqdqe lceilcmphy didsasvpsl eelnqfrqhv ttlretkasr reefvsikrq
      181 iilcmealdh tpdtsferdv vcededafcl sleniatlqk llrqlemqks qneavceglr
      241 tqirelwdrl qipeeereav atimsgskak vrkalqlevd rleelkmqnm kkvieairve
      301 lvqywdqcfy sqeqrqafap fcaedytesl lqlhdaeivr lknyyevhke lfegvqkwee
      361 twrlflefer kasdpnrftn rggnllkeek qraklqkmlp kleeelkari elweqehska
      421 fmvngqkfme yvaeqwemhr lekerakqer qlknkkqtet emlygsaprt pskrrglapn
      481 tpgkarklnt ttmsnatans sirpifggtv yhspvsrlpp sgskpvaast csgkktprtg
      541 rhgankenle lngsilsegs vpl
//
LOCUS       XP_047289253             563 aa            linear   PRI 05-AUG-2025
DEFINITION  protein regulator of cytokinesis 1 isoform X11 [Homo sapiens].
ACCESSION   XP_047289253
VERSION     XP_047289253.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433297.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..563
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..563
                     /product="protein regulator of cytokinesis 1 isoform X11"
                     /calculated_mol_wt=64866
     Region          16..420
                     /region_name="MAP65_ASE1"
                     /note="Microtubule associated protein (MAP65/ASE1 family);
                     pfam03999"
                     /db_xref="CDD:427641"
     CDS             1..563
                     /gene="PRC1"
                     /gene_synonym="ASE1; MAP65"
                     /coded_by="XM_047433297.1:119..1810"
                     /db_xref="GeneID:9055"
                     /db_xref="HGNC:HGNC:9341"
                     /db_xref="MIM:603484"
ORIGIN      
        1 mrrsevlaee sivclqkaln hlreiwelig ipedqrlqrt evvkkhikel ldmmiaeees
       61 lkerliksis vcqkelntlc selhvepfqe egettilqle kdlrtqvelm rkqkkerkqe
      121 lkllqeqdqe lceilcmphy didsasvpsl eelnqfrqhv ttlretklem qksqneavce
      181 glrtqirelw drlqipeeer eavatimsgs kakvrkalql evdrleelkm qnmkkvieai
      241 rvelvqywdq cfysqeqrqa fapfcaedyt esllqlhdae ivrlknyyev hkelfegvqk
      301 weetwrlfle ferkasdpnr ftnrggnllk eekqraklqk mlpkleeelk arielweqeh
      361 skafmvngqk fmeyvaeqwe mhrlekerak qerqlknkkq tetemlygsa prtpskrrgl
      421 apntpgkark lntttmsnat anssirpifg gtvyhspvsr lppsgskpva astcsgkktp
      481 rtgrhganke nlelngsils ggypgsaplq rnfsinsvas tysefakdps lsdsstvglq
      541 relskasksd atsgilnstn iqs
//
LOCUS       XP_006720822             563 aa            linear   PRI 05-AUG-2025
DEFINITION  protein regulator of cytokinesis 1 isoform X10 [Homo sapiens].
ACCESSION   XP_006720822
VERSION     XP_006720822.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720759.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..563
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..563
                     /product="protein regulator of cytokinesis 1 isoform X10"
                     /calculated_mol_wt=65550
     Region          16..477
                     /region_name="MAP65_ASE1"
                     /note="Microtubule associated protein (MAP65/ASE1 family);
                     pfam03999"
                     /db_xref="CDD:427641"
     CDS             1..563
                     /gene="PRC1"
                     /gene_synonym="ASE1; MAP65"
                     /coded_by="XM_006720759.3:119..1810"
                     /db_xref="GeneID:9055"
                     /db_xref="HGNC:HGNC:9341"
                     /db_xref="MIM:603484"
ORIGIN      
        1 mrrsevlaee sivclqkaln hlreiwelig ipedqrlqrt evvkkhikel ldmmiaeees
       61 lkerliksis vcqkelntlc selhvepfqe egettilqle kdlrtqvelm rkqkkerkqe
      121 lkllqeqdqe lceilcmphy didsasvpsl eelnqfrqhv ttlretkasr reefvsikrq
      181 iilcmealdh tpdtsferdv vcededafcl sleniatlqk llrqlemqks qneavceglr
      241 tqirelwdrl qipeeereav atimsgskak vrkalqlevd rleelkmqnm kkvieairve
      301 lvqywdqcfy sqeqrqafap fcaedytesl lqlhdaeivr lknyyevhke lfegvqkwee
      361 twrlflefer kasdpnrftn rggnllkeek qraklqkmlp kleeelkari elweqehska
      421 fmvngqkfme yvaeqwemhr lekerakqer qlknkkqtet emlygsaprt pskrrglapn
      481 tpgkarklnt ttmsnatans sirpifggtv yhspvsrlpp sgskpvaast csgkktprtg
      541 rhgankenle lngsilsegs vpl
//
LOCUS       XP_006720823             562 aa            linear   PRI 05-AUG-2025
DEFINITION  protein regulator of cytokinesis 1 isoform X12 [Homo sapiens].
ACCESSION   XP_006720823
VERSION     XP_006720823.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720760.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..562
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..562
                     /product="protein regulator of cytokinesis 1 isoform X12"
                     /calculated_mol_wt=65424
     Region          16..477
                     /region_name="MAP65_ASE1"
                     /note="Microtubule associated protein (MAP65/ASE1 family);
                     pfam03999"
                     /db_xref="CDD:427641"
     CDS             1..562
                     /gene="PRC1"
                     /gene_synonym="ASE1; MAP65"
                     /coded_by="XM_006720760.3:119..1807"
                     /db_xref="GeneID:9055"
                     /db_xref="HGNC:HGNC:9341"
                     /db_xref="MIM:603484"
ORIGIN      
        1 mrrsevlaee sivclqkaln hlreiwelig ipedqrlqrt evvkkhikel ldmmiaeees
       61 lkerliksis vcqkelntlc selhvepfqe egettilqle kdlrtqvelm rkqkkerkqe
      121 lkllqeqdqe lceilcmphy didsasvpsl eelnqfrqhv ttlretkasr reefvsikrq
      181 iilcmealdh tpdtsferdv vcededafcl sleniatlqk llrqlemqks qneavceglr
      241 tqirelwdrl qipeeereav atimsgskak vrkalqlevd rleelkmqnm kkvieairve
      301 lvqywdqcfy sqeqrqafap fcaedytesl lqlhdaeivr lknyyevhke lfegvqkwee
      361 twrlflefer kasdpnrftn rggnllkeek qraklqkmlp kleeelkari elweqehska
      421 fmvngqkfme yvaeqwemhr lekerakqer qlknkkqtet emlygsaprt pskrrglapn
      481 tpgkarklnt ttmsnatans sirpifggtv yhspvsrlpp sgskpvaast csgkktprtg
      541 rhgankenle lngsilsgqp ss
//
LOCUS       XP_047289254             550 aa            linear   PRI 05-AUG-2025
DEFINITION  protein regulator of cytokinesis 1 isoform X13 [Homo sapiens].
ACCESSION   XP_047289254
VERSION     XP_047289254.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433298.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..550
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..550
                     /product="protein regulator of cytokinesis 1 isoform X13"
                     /calculated_mol_wt=63848
     Region          16..420
                     /region_name="MAP65_ASE1"
                     /note="Microtubule associated protein (MAP65/ASE1 family);
                     pfam03999"
                     /db_xref="CDD:427641"
     CDS             1..550
                     /gene="PRC1"
                     /gene_synonym="ASE1; MAP65"
                     /coded_by="XM_047433298.1:119..1771"
                     /db_xref="GeneID:9055"
                     /db_xref="HGNC:HGNC:9341"
                     /db_xref="MIM:603484"
ORIGIN      
        1 mrrsevlaee sivclqkaln hlreiwelig ipedqrlqrt evvkkhikel ldmmiaeees
       61 lkerliksis vcqkelntlc selhvepfqe egettilqle kdlrtqvelm rkqkkerkqe
      121 lkllqeqdqe lceilcmphy didsasvpsl eelnqfrqhv ttlretklem qksqneavce
      181 glrtqirelw drlqipeeer eavatimsgs kakvrkalql evdrleelkm qnmkkvieai
      241 rvelvqywdq cfysqeqrqa fapfcaedyt esllqlhdae ivrlknyyev hkelfegvqk
      301 weetwrlfle ferkasdpnr ftnrggnllk eekqraklqk mlpkleeelk arielweqeh
      361 skafmvngqk fmeyvaeqwe mhrlekerak qerqlknkkq tetemlygsa prtpskrrgl
      421 apntpgkark lntttmsnat anssirpifg gtvyhspvsr lppsgskpva astcsgkktp
      481 rtgrhganke nlelngsils ggypgsaplq rnfsinsvas tysefadslp peenvfvcpk
      541 lrwpallpkr
//
LOCUS       XP_016878205             549 aa            linear   PRI 05-AUG-2025
DEFINITION  protein regulator of cytokinesis 1 isoform X14 [Homo sapiens].
ACCESSION   XP_016878205
VERSION     XP_016878205.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022716.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..549
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..549
                     /product="protein regulator of cytokinesis 1 isoform X14"
                     /calculated_mol_wt=63451
     Region          16..420
                     /region_name="MAP65_ASE1"
                     /note="Microtubule associated protein (MAP65/ASE1 family);
                     pfam03999"
                     /db_xref="CDD:427641"
     CDS             1..549
                     /gene="PRC1"
                     /gene_synonym="ASE1; MAP65"
                     /coded_by="XM_017022716.3:119..1768"
                     /db_xref="GeneID:9055"
                     /db_xref="HGNC:HGNC:9341"
                     /db_xref="MIM:603484"
ORIGIN      
        1 mrrsevlaee sivclqkaln hlreiwelig ipedqrlqrt evvkkhikel ldmmiaeees
       61 lkerliksis vcqkelntlc selhvepfqe egettilqle kdlrtqvelm rkqkkerkqe
      121 lkllqeqdqe lceilcmphy didsasvpsl eelnqfrqhv ttlretklem qksqneavce
      181 glrtqirelw drlqipeeer eavatimsgs kakvrkalql evdrleelkm qnmkkvieai
      241 rvelvqywdq cfysqeqrqa fapfcaedyt esllqlhdae ivrlknyyev hkelfegvqk
      301 weetwrlfle ferkasdpnr ftnrggnllk eekqraklqk mlpkleeelk arielweqeh
      361 skafmvngqk fmeyvaeqwe mhrlekerak qerqlknkkq tetemlygsa prtpskrrgl
      421 apntpgkark lntttmsnat anssirpifg gtvyhspvsr lppsgskpva astcsgkktp
      481 rtgrhganke nlelngsils ggypgsaplq rnfsinsvas tysefarels kasksdatsg
      541 ilnstniqs
//
LOCUS       XP_047289255             529 aa            linear   PRI 05-AUG-2025
DEFINITION  protein regulator of cytokinesis 1 isoform X15 [Homo sapiens].
ACCESSION   XP_047289255
VERSION     XP_047289255.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433299.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..529
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..529
                     /product="protein regulator of cytokinesis 1 isoform X15"
                     /calculated_mol_wt=62188
     Region          16..477
                     /region_name="MAP65_ASE1"
                     /note="Microtubule associated protein (MAP65/ASE1 family);
                     pfam03999"
                     /db_xref="CDD:427641"
     CDS             1..529
                     /gene="PRC1"
                     /gene_synonym="ASE1; MAP65"
                     /coded_by="XM_047433299.1:119..1708"
                     /db_xref="GeneID:9055"
                     /db_xref="HGNC:HGNC:9341"
                     /db_xref="MIM:603484"
ORIGIN      
        1 mrrsevlaee sivclqkaln hlreiwelig ipedqrlqrt evvkkhikel ldmmiaeees
       61 lkerliksis vcqkelntlc selhvepfqe egettilqle kdlrtqvelm rkqkkerkqe
      121 lkllqeqdqe lceilcmphy didsasvpsl eelnqfrqhv ttlretkasr reefvsikrq
      181 iilcmealdh tpdtsferdv vcededafcl sleniatlqk llrqlemqks qneavceglr
      241 tqirelwdrl qipeeereav atimsgskak vrkalqlevd rleelkmqnm kkvieairve
      301 lvqywdqcfy sqeqrqafap fcaedytesl lqlhdaeivr lknyyevhke lfegvqkwee
      361 twrlflefer kasdpnrftn rggnllkeek qraklqkmlp kleeelkari elweqehska
      421 fmvngqkfme yvaeqwemhr lekerakqer qlknkkqtet emlygsaprt pskrrglapn
      481 tpgkarkpva astcsgkktp rtgrhganke nlelngsils artfkgfqi
//
LOCUS       XP_047289256             527 aa            linear   PRI 05-AUG-2025
DEFINITION  protein regulator of cytokinesis 1 isoform X16 [Homo sapiens].
ACCESSION   XP_047289256
VERSION     XP_047289256.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433300.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..527
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..527
                     /product="protein regulator of cytokinesis 1 isoform X16"
                     /calculated_mol_wt=61435
     Region          16..420
                     /region_name="MAP65_ASE1"
                     /note="Microtubule associated protein (MAP65/ASE1 family);
                     pfam03999"
                     /db_xref="CDD:427641"
     CDS             1..527
                     /gene="PRC1"
                     /gene_synonym="ASE1; MAP65"
                     /coded_by="XM_047433300.1:119..1702"
                     /db_xref="GeneID:9055"
                     /db_xref="HGNC:HGNC:9341"
                     /db_xref="MIM:603484"
ORIGIN      
        1 mrrsevlaee sivclqkaln hlreiwelig ipedqrlqrt evvkkhikel ldmmiaeees
       61 lkerliksis vcqkelntlc selhvepfqe egettilqle kdlrtqvelm rkqkkerkqe
      121 lkllqeqdqe lceilcmphy didsasvpsl eelnqfrqhv ttlretklem qksqneavce
      181 glrtqirelw drlqipeeer eavatimsgs kakvrkalql evdrleelkm qnmkkvieai
      241 rvelvqywdq cfysqeqrqa fapfcaedyt esllqlhdae ivrlknyyev hkelfegvqk
      301 weetwrlfle ferkasdpnr ftnrggnllk eekqraklqk mlpkleeelk arielweqeh
      361 skafmvngqk fmeyvaeqwe mhrlekerak qerqlknkkq tetemlygsa prtpskrrgl
      421 apntpgkark pvaastcsgk ktprtgrhga nkenlelngs ilsggypgsa plqrnfsins
      481 vastysefak dpslsdsstv glqdslppee nvfvcpklrw pallpkr
//
LOCUS       XP_047289257             526 aa            linear   PRI 05-AUG-2025
DEFINITION  protein regulator of cytokinesis 1 isoform X17 [Homo sapiens].
ACCESSION   XP_047289257
VERSION     XP_047289257.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433301.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..526
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..526
                     /product="protein regulator of cytokinesis 1 isoform X17"
                     /calculated_mol_wt=61037
     Region          16..420
                     /region_name="MAP65_ASE1"
                     /note="Microtubule associated protein (MAP65/ASE1 family);
                     pfam03999"
                     /db_xref="CDD:427641"
     CDS             1..526
                     /gene="PRC1"
                     /gene_synonym="ASE1; MAP65"
                     /coded_by="XM_047433301.1:119..1699"
                     /db_xref="GeneID:9055"
                     /db_xref="HGNC:HGNC:9341"
                     /db_xref="MIM:603484"
ORIGIN      
        1 mrrsevlaee sivclqkaln hlreiwelig ipedqrlqrt evvkkhikel ldmmiaeees
       61 lkerliksis vcqkelntlc selhvepfqe egettilqle kdlrtqvelm rkqkkerkqe
      121 lkllqeqdqe lceilcmphy didsasvpsl eelnqfrqhv ttlretklem qksqneavce
      181 glrtqirelw drlqipeeer eavatimsgs kakvrkalql evdrleelkm qnmkkvieai
      241 rvelvqywdq cfysqeqrqa fapfcaedyt esllqlhdae ivrlknyyev hkelfegvqk
      301 weetwrlfle ferkasdpnr ftnrggnllk eekqraklqk mlpkleeelk arielweqeh
      361 skafmvngqk fmeyvaeqwe mhrlekerak qerqlknkkq tetemlygsa prtpskrrgl
      421 apntpgkark pvaastcsgk ktprtgrhga nkenlelngs ilsggypgsa plqrnfsins
      481 vastysefak dpslsdsstv glqrelskas ksdatsgiln stniqs
//
LOCUS       XP_047289259             526 aa            linear   PRI 05-AUG-2025
DEFINITION  protein regulator of cytokinesis 1 isoform X18 [Homo sapiens].
ACCESSION   XP_047289259
VERSION     XP_047289259.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433303.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..526
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..526
                     /product="protein regulator of cytokinesis 1 isoform X18"
                     /calculated_mol_wt=61721
     Region          16..477
                     /region_name="MAP65_ASE1"
                     /note="Microtubule associated protein (MAP65/ASE1 family);
                     pfam03999"
                     /db_xref="CDD:427641"
     CDS             1..526
                     /gene="PRC1"
                     /gene_synonym="ASE1; MAP65"
                     /coded_by="XM_047433303.1:119..1699"
                     /db_xref="GeneID:9055"
                     /db_xref="HGNC:HGNC:9341"
                     /db_xref="MIM:603484"
ORIGIN      
        1 mrrsevlaee sivclqkaln hlreiwelig ipedqrlqrt evvkkhikel ldmmiaeees
       61 lkerliksis vcqkelntlc selhvepfqe egettilqle kdlrtqvelm rkqkkerkqe
      121 lkllqeqdqe lceilcmphy didsasvpsl eelnqfrqhv ttlretkasr reefvsikrq
      181 iilcmealdh tpdtsferdv vcededafcl sleniatlqk llrqlemqks qneavceglr
      241 tqirelwdrl qipeeereav atimsgskak vrkalqlevd rleelkmqnm kkvieairve
      301 lvqywdqcfy sqeqrqafap fcaedytesl lqlhdaeivr lknyyevhke lfegvqkwee
      361 twrlflefer kasdpnrftn rggnllkeek qraklqkmlp kleeelkari elweqehska
      421 fmvngqkfme yvaeqwemhr lekerakqer qlknkkqtet emlygsaprt pskrrglapn
      481 tpgkarkpva astcsgkktp rtgrhganke nlelngsils egsvpl
//
LOCUS       XP_047289260             525 aa            linear   PRI 05-AUG-2025
DEFINITION  protein regulator of cytokinesis 1 isoform X19 [Homo sapiens].
ACCESSION   XP_047289260
VERSION     XP_047289260.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433304.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..525
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..525
                     /product="protein regulator of cytokinesis 1 isoform X19"
                     /calculated_mol_wt=61595
     Region          16..477
                     /region_name="MAP65_ASE1"
                     /note="Microtubule associated protein (MAP65/ASE1 family);
                     pfam03999"
                     /db_xref="CDD:427641"
     CDS             1..525
                     /gene="PRC1"
                     /gene_synonym="ASE1; MAP65"
                     /coded_by="XM_047433304.1:119..1696"
                     /db_xref="GeneID:9055"
                     /db_xref="HGNC:HGNC:9341"
                     /db_xref="MIM:603484"
ORIGIN      
        1 mrrsevlaee sivclqkaln hlreiwelig ipedqrlqrt evvkkhikel ldmmiaeees
       61 lkerliksis vcqkelntlc selhvepfqe egettilqle kdlrtqvelm rkqkkerkqe
      121 lkllqeqdqe lceilcmphy didsasvpsl eelnqfrqhv ttlretkasr reefvsikrq
      181 iilcmealdh tpdtsferdv vcededafcl sleniatlqk llrqlemqks qneavceglr
      241 tqirelwdrl qipeeereav atimsgskak vrkalqlevd rleelkmqnm kkvieairve
      301 lvqywdqcfy sqeqrqafap fcaedytesl lqlhdaeivr lknyyevhke lfegvqkwee
      361 twrlflefer kasdpnrftn rggnllkeek qraklqkmlp kleeelkari elweqehska
      421 fmvngqkfme yvaeqwemhr lekerakqer qlknkkqtet emlygsaprt pskrrglapn
      481 tpgkarkpva astcsgkktp rtgrhganke nlelngsils gqpss
//
LOCUS       XP_011520494             514 aa            linear   PRI 05-AUG-2025
DEFINITION  protein regulator of cytokinesis 1 isoform X20 [Homo sapiens].
ACCESSION   XP_011520494
VERSION     XP_011520494.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522192.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..514
                     /product="protein regulator of cytokinesis 1 isoform X20"
                     /calculated_mol_wt=59524
     Region          16..370
                     /region_name="MAP65_ASE1"
                     /note="Microtubule associated protein (MAP65/ASE1 family);
                     pfam03999"
                     /db_xref="CDD:427641"
     CDS             1..514
                     /gene="PRC1"
                     /gene_synonym="ASE1; MAP65"
                     /coded_by="XM_011522192.3:119..1663"
                     /db_xref="GeneID:9055"
                     /db_xref="HGNC:HGNC:9341"
                     /db_xref="MIM:603484"
ORIGIN      
        1 mrrsevlaee sivclqkaln hlreiwelig ipedqrlqrt evvkkhikel ldmmiaeees
       61 lkerliksis vcqkelntlc selhvepfqe egettilqle kdlrtqvelm rkqkkerkqe
      121 lkllqeqdqe lceilcmphy didsasvpsl eelnqfrqhv ttlretklql evdrleelkm
      181 qnmkkvieai rvelvqywdq cfysqeqrqa fapfcaedyt esllqlhdae ivrlknyyev
      241 hkelfegvqk weetwrlfle ferkasdpnr ftnrggnllk eekqraklqk mlpkleeelk
      301 arielweqeh skafmvngqk fmeyvaeqwe mhrlekerak qerqlknkkq tetemlygsa
      361 prtpskrrgl apntpgkark lntttmsnat anssirpifg gtvyhspvsr lppsgskpva
      421 astcsgkktp rtgrhganke nlelngsils ggypgsaplq rnfsinsvas tysefakdps
      481 lsdsstvglq dslppeenvf vcpklrwpal lpkr
//
LOCUS       XP_047289261             513 aa            linear   PRI 05-AUG-2025
DEFINITION  protein regulator of cytokinesis 1 isoform X21 [Homo sapiens].
ACCESSION   XP_047289261
VERSION     XP_047289261.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433305.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..513
                     /product="protein regulator of cytokinesis 1 isoform X21"
                     /calculated_mol_wt=60019
     Region          16..420
                     /region_name="MAP65_ASE1"
                     /note="Microtubule associated protein (MAP65/ASE1 family);
                     pfam03999"
                     /db_xref="CDD:427641"
     CDS             1..513
                     /gene="PRC1"
                     /gene_synonym="ASE1; MAP65"
                     /coded_by="XM_047433305.1:119..1660"
                     /db_xref="GeneID:9055"
                     /db_xref="HGNC:HGNC:9341"
                     /db_xref="MIM:603484"
ORIGIN      
        1 mrrsevlaee sivclqkaln hlreiwelig ipedqrlqrt evvkkhikel ldmmiaeees
       61 lkerliksis vcqkelntlc selhvepfqe egettilqle kdlrtqvelm rkqkkerkqe
      121 lkllqeqdqe lceilcmphy didsasvpsl eelnqfrqhv ttlretklem qksqneavce
      181 glrtqirelw drlqipeeer eavatimsgs kakvrkalql evdrleelkm qnmkkvieai
      241 rvelvqywdq cfysqeqrqa fapfcaedyt esllqlhdae ivrlknyyev hkelfegvqk
      301 weetwrlfle ferkasdpnr ftnrggnllk eekqraklqk mlpkleeelk arielweqeh
      361 skafmvngqk fmeyvaeqwe mhrlekerak qerqlknkkq tetemlygsa prtpskrrgl
      421 apntpgkark pvaastcsgk ktprtgrhga nkenlelngs ilsggypgsa plqrnfsins
      481 vastysefad slppeenvfv cpklrwpall pkr
//
LOCUS       XP_047289262             512 aa            linear   PRI 05-AUG-2025
DEFINITION  protein regulator of cytokinesis 1 isoform X22 [Homo sapiens].
ACCESSION   XP_047289262
VERSION     XP_047289262.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433306.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..512
                     /product="protein regulator of cytokinesis 1 isoform X22"
                     /calculated_mol_wt=59621
     Region          16..420
                     /region_name="MAP65_ASE1"
                     /note="Microtubule associated protein (MAP65/ASE1 family);
                     pfam03999"
                     /db_xref="CDD:427641"
     CDS             1..512
                     /gene="PRC1"
                     /gene_synonym="ASE1; MAP65"
                     /coded_by="XM_047433306.1:119..1657"
                     /db_xref="GeneID:9055"
                     /db_xref="HGNC:HGNC:9341"
                     /db_xref="MIM:603484"
ORIGIN      
        1 mrrsevlaee sivclqkaln hlreiwelig ipedqrlqrt evvkkhikel ldmmiaeees
       61 lkerliksis vcqkelntlc selhvepfqe egettilqle kdlrtqvelm rkqkkerkqe
      121 lkllqeqdqe lceilcmphy didsasvpsl eelnqfrqhv ttlretklem qksqneavce
      181 glrtqirelw drlqipeeer eavatimsgs kakvrkalql evdrleelkm qnmkkvieai
      241 rvelvqywdq cfysqeqrqa fapfcaedyt esllqlhdae ivrlknyyev hkelfegvqk
      301 weetwrlfle ferkasdpnr ftnrggnllk eekqraklqk mlpkleeelk arielweqeh
      361 skafmvngqk fmeyvaeqwe mhrlekerak qerqlknkkq tetemlygsa prtpskrrgl
      421 apntpgkark pvaastcsgk ktprtgrhga nkenlelngs ilsggypgsa plqrnfsins
      481 vastysefar elskasksda tsgilnstni qs
//
LOCUS       XP_047289263             509 aa            linear   PRI 05-AUG-2025
DEFINITION  protein regulator of cytokinesis 1 isoform X23 [Homo sapiens].
ACCESSION   XP_047289263
VERSION     XP_047289263.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433307.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..509
                     /product="protein regulator of cytokinesis 1 isoform X23"
                     /calculated_mol_wt=59407
     Region          16..420
                     /region_name="MAP65_ASE1"
                     /note="Microtubule associated protein (MAP65/ASE1 family);
                     pfam03999"
                     /db_xref="CDD:427641"
     CDS             1..509
                     /gene="PRC1"
                     /gene_synonym="ASE1; MAP65"
                     /coded_by="XM_047433307.1:119..1648"
                     /db_xref="GeneID:9055"
                     /db_xref="HGNC:HGNC:9341"
                     /db_xref="MIM:603484"
ORIGIN      
        1 mrrsevlaee sivclqkaln hlreiwelig ipedqrlqrt evvkkhikel ldmmiaeees
       61 lkerliksis vcqkelntlc selhvepfqe egettilqle kdlrtqvelm rkqkkerkqe
      121 lkllqeqdqe lceilcmphy didsasvpsl eelnqfrqhv ttlretklem qksqneavce
      181 glrtqirelw drlqipeeer eavatimsgs kakvrkalql evdrleelkm qnmkkvieai
      241 rvelvqywdq cfysqeqrqa fapfcaedyt esllqlhdae ivrlknyyev hkelfegvqk
      301 weetwrlfle ferkasdpnr ftnrggnllk eekqraklqk mlpkleeelk arielweqeh
      361 skafmvngqk fmeyvaeqwe mhrlekerak qerqlknkkq tetemlygsa prtpskrrgl
      421 apntpgkark lntttmsnat anssirpifg gtvyhspvsr lppsgskpva astcsgkktp
      481 rtgrhganke nlelngsils artfkgfqi
//
LOCUS       XP_047289264             506 aa            linear   PRI 05-AUG-2025
DEFINITION  protein regulator of cytokinesis 1 isoform X24 [Homo sapiens].
ACCESSION   XP_047289264
VERSION     XP_047289264.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433308.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..506
                     /product="protein regulator of cytokinesis 1 isoform X24"
                     /calculated_mol_wt=58941
     Region          16..420
                     /region_name="MAP65_ASE1"
                     /note="Microtubule associated protein (MAP65/ASE1 family);
                     pfam03999"
                     /db_xref="CDD:427641"
     CDS             1..506
                     /gene="PRC1"
                     /gene_synonym="ASE1; MAP65"
                     /coded_by="XM_047433308.1:119..1639"
                     /db_xref="GeneID:9055"
                     /db_xref="HGNC:HGNC:9341"
                     /db_xref="MIM:603484"
ORIGIN      
        1 mrrsevlaee sivclqkaln hlreiwelig ipedqrlqrt evvkkhikel ldmmiaeees
       61 lkerliksis vcqkelntlc selhvepfqe egettilqle kdlrtqvelm rkqkkerkqe
      121 lkllqeqdqe lceilcmphy didsasvpsl eelnqfrqhv ttlretklem qksqneavce
      181 glrtqirelw drlqipeeer eavatimsgs kakvrkalql evdrleelkm qnmkkvieai
      241 rvelvqywdq cfysqeqrqa fapfcaedyt esllqlhdae ivrlknyyev hkelfegvqk
      301 weetwrlfle ferkasdpnr ftnrggnllk eekqraklqk mlpkleeelk arielweqeh
      361 skafmvngqk fmeyvaeqwe mhrlekerak qerqlknkkq tetemlygsa prtpskrrgl
      421 apntpgkark lntttmsnat anssirpifg gtvyhspvsr lppsgskpva astcsgkktp
      481 rtgrhganke nlelngsils egsvpl
//
LOCUS       XP_047289265             505 aa            linear   PRI 05-AUG-2025
DEFINITION  protein regulator of cytokinesis 1 isoform X25 [Homo sapiens].
ACCESSION   XP_047289265
VERSION     XP_047289265.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433309.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..505
                     /product="protein regulator of cytokinesis 1 isoform X25"
                     /calculated_mol_wt=58815
     Region          16..420
                     /region_name="MAP65_ASE1"
                     /note="Microtubule associated protein (MAP65/ASE1 family);
                     pfam03999"
                     /db_xref="CDD:427641"
     CDS             1..505
                     /gene="PRC1"
                     /gene_synonym="ASE1; MAP65"
                     /coded_by="XM_047433309.1:119..1636"
                     /db_xref="GeneID:9055"
                     /db_xref="HGNC:HGNC:9341"
                     /db_xref="MIM:603484"
ORIGIN      
        1 mrrsevlaee sivclqkaln hlreiwelig ipedqrlqrt evvkkhikel ldmmiaeees
       61 lkerliksis vcqkelntlc selhvepfqe egettilqle kdlrtqvelm rkqkkerkqe
      121 lkllqeqdqe lceilcmphy didsasvpsl eelnqfrqhv ttlretklem qksqneavce
      181 glrtqirelw drlqipeeer eavatimsgs kakvrkalql evdrleelkm qnmkkvieai
      241 rvelvqywdq cfysqeqrqa fapfcaedyt esllqlhdae ivrlknyyev hkelfegvqk
      301 weetwrlfle ferkasdpnr ftnrggnllk eekqraklqk mlpkleeelk arielweqeh
      361 skafmvngqk fmeyvaeqwe mhrlekerak qerqlknkkq tetemlygsa prtpskrrgl
      421 apntpgkark lntttmsnat anssirpifg gtvyhspvsr lppsgskpva astcsgkktp
      481 rtgrhganke nlelngsils gqpss
//
LOCUS       XP_047289266             499 aa            linear   PRI 05-AUG-2025
DEFINITION  protein regulator of cytokinesis 1 isoform X26 [Homo sapiens].
ACCESSION   XP_047289266
VERSION     XP_047289266.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433310.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..499
                     /product="protein regulator of cytokinesis 1 isoform X26"
                     /calculated_mol_wt=57711
     Region          16..370
                     /region_name="MAP65_ASE1"
                     /note="Microtubule associated protein (MAP65/ASE1 family);
                     pfam03999"
                     /db_xref="CDD:427641"
     CDS             1..499
                     /gene="PRC1"
                     /gene_synonym="ASE1; MAP65"
                     /coded_by="XM_047433310.1:119..1618"
                     /db_xref="GeneID:9055"
                     /db_xref="HGNC:HGNC:9341"
                     /db_xref="MIM:603484"
ORIGIN      
        1 mrrsevlaee sivclqkaln hlreiwelig ipedqrlqrt evvkkhikel ldmmiaeees
       61 lkerliksis vcqkelntlc selhvepfqe egettilqle kdlrtqvelm rkqkkerkqe
      121 lkllqeqdqe lceilcmphy didsasvpsl eelnqfrqhv ttlretklql evdrleelkm
      181 qnmkkvieai rvelvqywdq cfysqeqrqa fapfcaedyt esllqlhdae ivrlknyyev
      241 hkelfegvqk weetwrlfle ferkasdpnr ftnrggnllk eekqraklqk mlpkleeelk
      301 arielweqeh skafmvngqk fmeyvaeqwe mhrlekerak qerqlknkkq tetemlygsa
      361 prtpskrrgl apntpgkark lntttmsnat anssirpifg gtvyhspvsr lppsgskpva
      421 astcsgkktp rtgrhganke nlelngsils ggypgsaplq rnfsinsvas tysefarels
      481 kasksdatsg ilnstniqs
//
LOCUS       XP_047289267             472 aa            linear   PRI 05-AUG-2025
DEFINITION  protein regulator of cytokinesis 1 isoform X27 [Homo sapiens].
ACCESSION   XP_047289267
VERSION     XP_047289267.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433311.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..472
                     /product="protein regulator of cytokinesis 1 isoform X27"
                     /calculated_mol_wt=55578
     Region          16..420
                     /region_name="MAP65_ASE1"
                     /note="Microtubule associated protein (MAP65/ASE1 family);
                     pfam03999"
                     /db_xref="CDD:427641"
     CDS             1..472
                     /gene="PRC1"
                     /gene_synonym="ASE1; MAP65"
                     /coded_by="XM_047433311.1:119..1537"
                     /db_xref="GeneID:9055"
                     /db_xref="HGNC:HGNC:9341"
                     /db_xref="MIM:603484"
ORIGIN      
        1 mrrsevlaee sivclqkaln hlreiwelig ipedqrlqrt evvkkhikel ldmmiaeees
       61 lkerliksis vcqkelntlc selhvepfqe egettilqle kdlrtqvelm rkqkkerkqe
      121 lkllqeqdqe lceilcmphy didsasvpsl eelnqfrqhv ttlretklem qksqneavce
      181 glrtqirelw drlqipeeer eavatimsgs kakvrkalql evdrleelkm qnmkkvieai
      241 rvelvqywdq cfysqeqrqa fapfcaedyt esllqlhdae ivrlknyyev hkelfegvqk
      301 weetwrlfle ferkasdpnr ftnrggnllk eekqraklqk mlpkleeelk arielweqeh
      361 skafmvngqk fmeyvaeqwe mhrlekerak qerqlknkkq tetemlygsa prtpskrrgl
      421 apntpgkark pvaastcsgk ktprtgrhga nkenlelngs ilsartfkgf qi
//
LOCUS       XP_047289269             468 aa            linear   PRI 05-AUG-2025
DEFINITION  protein regulator of cytokinesis 1 isoform X28 [Homo sapiens].
ACCESSION   XP_047289269
VERSION     XP_047289269.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433313.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..468
                     /product="protein regulator of cytokinesis 1 isoform X28"
                     /calculated_mol_wt=54985
     Region          16..420
                     /region_name="MAP65_ASE1"
                     /note="Microtubule associated protein (MAP65/ASE1 family);
                     pfam03999"
                     /db_xref="CDD:427641"
     CDS             1..468
                     /gene="PRC1"
                     /gene_synonym="ASE1; MAP65"
                     /coded_by="XM_047433313.1:119..1525"
                     /db_xref="GeneID:9055"
                     /db_xref="HGNC:HGNC:9341"
                     /db_xref="MIM:603484"
ORIGIN      
        1 mrrsevlaee sivclqkaln hlreiwelig ipedqrlqrt evvkkhikel ldmmiaeees
       61 lkerliksis vcqkelntlc selhvepfqe egettilqle kdlrtqvelm rkqkkerkqe
      121 lkllqeqdqe lceilcmphy didsasvpsl eelnqfrqhv ttlretklem qksqneavce
      181 glrtqirelw drlqipeeer eavatimsgs kakvrkalql evdrleelkm qnmkkvieai
      241 rvelvqywdq cfysqeqrqa fapfcaedyt esllqlhdae ivrlknyyev hkelfegvqk
      301 weetwrlfle ferkasdpnr ftnrggnllk eekqraklqk mlpkleeelk arielweqeh
      361 skafmvngqk fmeyvaeqwe mhrlekerak qerqlknkkq tetemlygsa prtpskrrgl
      421 apntpgkark pvaastcsgk ktprtgrhga nkenlelngs ilsgqpss
//
LOCUS       XP_047289270             459 aa            linear   PRI 05-AUG-2025
DEFINITION  protein regulator of cytokinesis 1 isoform X29 [Homo sapiens].
ACCESSION   XP_047289270
VERSION     XP_047289270.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433314.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..459
                     /product="protein regulator of cytokinesis 1 isoform X29"
                     /calculated_mol_wt=53668
     Region          16..370
                     /region_name="MAP65_ASE1"
                     /note="Microtubule associated protein (MAP65/ASE1 family);
                     pfam03999"
                     /db_xref="CDD:427641"
     CDS             1..459
                     /gene="PRC1"
                     /gene_synonym="ASE1; MAP65"
                     /coded_by="XM_047433314.1:119..1498"
                     /db_xref="GeneID:9055"
                     /db_xref="HGNC:HGNC:9341"
                     /db_xref="MIM:603484"
ORIGIN      
        1 mrrsevlaee sivclqkaln hlreiwelig ipedqrlqrt evvkkhikel ldmmiaeees
       61 lkerliksis vcqkelntlc selhvepfqe egettilqle kdlrtqvelm rkqkkerkqe
      121 lkllqeqdqe lceilcmphy didsasvpsl eelnqfrqhv ttlretklql evdrleelkm
      181 qnmkkvieai rvelvqywdq cfysqeqrqa fapfcaedyt esllqlhdae ivrlknyyev
      241 hkelfegvqk weetwrlfle ferkasdpnr ftnrggnllk eekqraklqk mlpkleeelk
      301 arielweqeh skafmvngqk fmeyvaeqwe mhrlekerak qerqlknkkq tetemlygsa
      361 prtpskrrgl apntpgkark lntttmsnat anssirpifg gtvyhspvsr lppsgskpva
      421 astcsgkktp rtgrhganke nlelngsils artfkgfqi
//
LOCUS       XP_047289272             376 aa            linear   PRI 05-AUG-2025
DEFINITION  RCC1 domain-containing protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047289272
VERSION     XP_047289272.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433316.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..376
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..376
                     /product="RCC1 domain-containing protein 1 isoform X1"
                     /calculated_mol_wt=39948
     Region          <160..368
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     CDS             1..376
                     /gene="RCCD1"
                     /coded_by="XM_047433316.1:693..1823"
                     /db_xref="GeneID:91433"
                     /db_xref="HGNC:HGNC:30457"
                     /db_xref="MIM:617997"
ORIGIN      
        1 maeerpgawf gfgfcgfgqe lgsgrgrqvh spsplragvd icrvsaswsy tafvtrggrl
       61 elsgsasgaa grckdawase gllavlragp gpeallqvwa aesalrgepl waqnvvpeae
      121 geddpageaq agrlpllpca rayvsprapf yrplapelra rqlelgaeha llldaagqvf
      181 swgggrhgql ghgtleaele prllealqgl vmaevaaggw hsvcvsetgd iyiwgwnesg
      241 qlalptrnla edgetvarea telnedgsqv krtggaedga papfiavqpf palldlpmgs
      301 davkascgsr htavvtrtge lytwgwgkyg qlghedttsl drprrveyfv dkqlqvkavt
      361 cgpwntyvya vekgks
//
LOCUS       XP_047289273             376 aa            linear   PRI 05-AUG-2025
DEFINITION  RCC1 domain-containing protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047289273
VERSION     XP_047289273.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433317.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..376
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..376
                     /product="RCC1 domain-containing protein 1 isoform X1"
                     /calculated_mol_wt=39948
     Region          <160..368
                     /region_name="ATS1"
                     /note="Alpha-tubulin suppressor ATS1 and related RCC1
                     domain-containing proteins [Cell cycle control, cell
                     division, chromosome partitioning, Cytoskeleton]; COG5184"
                     /db_xref="CDD:444065"
     CDS             1..376
                     /gene="RCCD1"
                     /coded_by="XM_047433317.1:777..1907"
                     /db_xref="GeneID:91433"
                     /db_xref="HGNC:HGNC:30457"
                     /db_xref="MIM:617997"
ORIGIN      
        1 maeerpgawf gfgfcgfgqe lgsgrgrqvh spsplragvd icrvsaswsy tafvtrggrl
       61 elsgsasgaa grckdawase gllavlragp gpeallqvwa aesalrgepl waqnvvpeae
      121 geddpageaq agrlpllpca rayvsprapf yrplapelra rqlelgaeha llldaagqvf
      181 swgggrhgql ghgtleaele prllealqgl vmaevaaggw hsvcvsetgd iyiwgwnesg
      241 qlalptrnla edgetvarea telnedgsqv krtggaedga papfiavqpf palldlpmgs
      301 davkascgsr htavvtrtge lytwgwgkyg qlghedttsl drprrveyfv dkqlqvkavt
      361 cgpwntyvya vekgks
//
LOCUS       XP_047289274             205 aa            linear   PRI 05-AUG-2025
DEFINITION  RCC1 domain-containing protein 1 isoform X2 [Homo sapiens].
ACCESSION   XP_047289274
VERSION     XP_047289274.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433318.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..205
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..205
                     /product="RCC1 domain-containing protein 1 isoform X2"
                     /calculated_mol_wt=21035
     CDS             1..205
                     /gene="RCCD1"
                     /coded_by="XM_047433318.1:1124..1741"
                     /db_xref="GeneID:91433"
                     /db_xref="HGNC:HGNC:30457"
                     /db_xref="MIM:617997"
ORIGIN      
        1 maeerpgawf gfgfcgfgqe lgsgrgrqvh spsplragvd icrvsaswsy tafvtrggrl
       61 elsgsasgaa grckdawase gllavlragp gpeallqvwa aesalrgepl waqnvvpeae
      121 geddpageaq agrlpllpca rayvsprapf yrplapelra rqlelgaeha llldaagqaw
      181 tagpwdpggr agatavggva gpshg
//
LOCUS       XP_011520505             692 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium/nucleoside cotransporter 1 isoform X1 [Homo sapiens].
ACCESSION   XP_011520505
VERSION     XP_011520505.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522203.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..692
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..692
                     /product="sodium/nucleoside cotransporter 1 isoform X1"
                     /calculated_mol_wt=76363
     Region          179..590
                     /region_name="nupC"
                     /note="nucleoside transporter; TIGR00804"
                     /db_xref="CDD:273278"
     CDS             1..692
                     /gene="SLC28A1"
                     /gene_synonym="CNT1; HCNT1; URCTU"
                     /coded_by="XM_011522203.3:223..2301"
                     /db_xref="GeneID:9154"
                     /db_xref="HGNC:HGNC:11001"
                     /db_xref="MIM:606207"
ORIGIN      
        1 mendpsrrre sisltpvakg lenmgadfle sleegqlprs dlspaeirss wseaapkpfs
       61 rwrnlqpalr arsfcrehmq lfrwigtgll ctglsafllv aclldfqral alfvltcvvl
      121 tflghrllkr llgpklrrfl kpqghprlll wfkrglalaa flglvlwlsl dtsqrpeqlv
      181 sfagicvfva llfacskhhc avswravswg lglqfvlgll virtepgfia fewlgeqiri
      241 flsytkagss fvfgealvkd vfafqvlpii vffscvisvl yhvglmqwvi lkiawlmqvt
      301 mgttatetls vagnifvsqt eapllirpyl admtlsevhv vmtggyatia gsllgayisf
      361 gidatsliaa svmaapcala lsklvypeve eskfrreegv kltygdaqnl ieaastgaai
      421 svkvvaniaa nliaflavld finaalswlg dmvdiqglsf qlicsyilrp vaflmgvawe
      481 dcpvvaellg iklflnefva yqdlskykqr rlagaeewvg drkqwisvra evlttfalcg
      541 fanfssigim lggltsmvpq rksdfsqivl ralftgacvs lvnacmagil ymprgaevdc
      601 msllnttlss ssfeiyqccr eafqrqcmsq eqvedeartq hggthfssts kkavthrsrl
      661 ptrwthemll htllhvskfl asndsmcfsd gp
//
LOCUS       XP_011520506             692 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium/nucleoside cotransporter 1 isoform X1 [Homo sapiens].
ACCESSION   XP_011520506
VERSION     XP_011520506.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522204.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..692
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..692
                     /product="sodium/nucleoside cotransporter 1 isoform X1"
                     /calculated_mol_wt=76363
     Region          179..590
                     /region_name="nupC"
                     /note="nucleoside transporter; TIGR00804"
                     /db_xref="CDD:273278"
     CDS             1..692
                     /gene="SLC28A1"
                     /gene_synonym="CNT1; HCNT1; URCTU"
                     /coded_by="XM_011522204.4:424..2502"
                     /db_xref="GeneID:9154"
                     /db_xref="HGNC:HGNC:11001"
                     /db_xref="MIM:606207"
ORIGIN      
        1 mendpsrrre sisltpvakg lenmgadfle sleegqlprs dlspaeirss wseaapkpfs
       61 rwrnlqpalr arsfcrehmq lfrwigtgll ctglsafllv aclldfqral alfvltcvvl
      121 tflghrllkr llgpklrrfl kpqghprlll wfkrglalaa flglvlwlsl dtsqrpeqlv
      181 sfagicvfva llfacskhhc avswravswg lglqfvlgll virtepgfia fewlgeqiri
      241 flsytkagss fvfgealvkd vfafqvlpii vffscvisvl yhvglmqwvi lkiawlmqvt
      301 mgttatetls vagnifvsqt eapllirpyl admtlsevhv vmtggyatia gsllgayisf
      361 gidatsliaa svmaapcala lsklvypeve eskfrreegv kltygdaqnl ieaastgaai
      421 svkvvaniaa nliaflavld finaalswlg dmvdiqglsf qlicsyilrp vaflmgvawe
      481 dcpvvaellg iklflnefva yqdlskykqr rlagaeewvg drkqwisvra evlttfalcg
      541 fanfssigim lggltsmvpq rksdfsqivl ralftgacvs lvnacmagil ymprgaevdc
      601 msllnttlss ssfeiyqccr eafqrqcmsq eqvedeartq hggthfssts kkavthrsrl
      661 ptrwthemll htllhvskfl asndsmcfsd gp
//
LOCUS       XP_011520507             692 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium/nucleoside cotransporter 1 isoform X1 [Homo sapiens].
ACCESSION   XP_011520507
VERSION     XP_011520507.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522205.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..692
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..692
                     /product="sodium/nucleoside cotransporter 1 isoform X1"
                     /calculated_mol_wt=76363
     Region          179..590
                     /region_name="nupC"
                     /note="nucleoside transporter; TIGR00804"
                     /db_xref="CDD:273278"
     CDS             1..692
                     /gene="SLC28A1"
                     /gene_synonym="CNT1; HCNT1; URCTU"
                     /coded_by="XM_011522205.4:308..2386"
                     /db_xref="GeneID:9154"
                     /db_xref="HGNC:HGNC:11001"
                     /db_xref="MIM:606207"
ORIGIN      
        1 mendpsrrre sisltpvakg lenmgadfle sleegqlprs dlspaeirss wseaapkpfs
       61 rwrnlqpalr arsfcrehmq lfrwigtgll ctglsafllv aclldfqral alfvltcvvl
      121 tflghrllkr llgpklrrfl kpqghprlll wfkrglalaa flglvlwlsl dtsqrpeqlv
      181 sfagicvfva llfacskhhc avswravswg lglqfvlgll virtepgfia fewlgeqiri
      241 flsytkagss fvfgealvkd vfafqvlpii vffscvisvl yhvglmqwvi lkiawlmqvt
      301 mgttatetls vagnifvsqt eapllirpyl admtlsevhv vmtggyatia gsllgayisf
      361 gidatsliaa svmaapcala lsklvypeve eskfrreegv kltygdaqnl ieaastgaai
      421 svkvvaniaa nliaflavld finaalswlg dmvdiqglsf qlicsyilrp vaflmgvawe
      481 dcpvvaellg iklflnefva yqdlskykqr rlagaeewvg drkqwisvra evlttfalcg
      541 fanfssigim lggltsmvpq rksdfsqivl ralftgacvs lvnacmagil ymprgaevdc
      601 msllnttlss ssfeiyqccr eafqrqcmsq eqvedeartq hggthfssts kkavthrsrl
      661 ptrwthemll htllhvskfl asndsmcfsd gp
//
LOCUS       XP_011520508             692 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium/nucleoside cotransporter 1 isoform X1 [Homo sapiens].
ACCESSION   XP_011520508
VERSION     XP_011520508.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522206.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..692
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..692
                     /product="sodium/nucleoside cotransporter 1 isoform X1"
                     /calculated_mol_wt=76363
     Region          179..590
                     /region_name="nupC"
                     /note="nucleoside transporter; TIGR00804"
                     /db_xref="CDD:273278"
     CDS             1..692
                     /gene="SLC28A1"
                     /gene_synonym="CNT1; HCNT1; URCTU"
                     /coded_by="XM_011522206.4:107..2185"
                     /db_xref="GeneID:9154"
                     /db_xref="HGNC:HGNC:11001"
                     /db_xref="MIM:606207"
ORIGIN      
        1 mendpsrrre sisltpvakg lenmgadfle sleegqlprs dlspaeirss wseaapkpfs
       61 rwrnlqpalr arsfcrehmq lfrwigtgll ctglsafllv aclldfqral alfvltcvvl
      121 tflghrllkr llgpklrrfl kpqghprlll wfkrglalaa flglvlwlsl dtsqrpeqlv
      181 sfagicvfva llfacskhhc avswravswg lglqfvlgll virtepgfia fewlgeqiri
      241 flsytkagss fvfgealvkd vfafqvlpii vffscvisvl yhvglmqwvi lkiawlmqvt
      301 mgttatetls vagnifvsqt eapllirpyl admtlsevhv vmtggyatia gsllgayisf
      361 gidatsliaa svmaapcala lsklvypeve eskfrreegv kltygdaqnl ieaastgaai
      421 svkvvaniaa nliaflavld finaalswlg dmvdiqglsf qlicsyilrp vaflmgvawe
      481 dcpvvaellg iklflnefva yqdlskykqr rlagaeewvg drkqwisvra evlttfalcg
      541 fanfssigim lggltsmvpq rksdfsqivl ralftgacvs lvnacmagil ymprgaevdc
      601 msllnttlss ssfeiyqccr eafqrqcmsq eqvedeartq hggthfssts kkavthrsrl
      661 ptrwthemll htllhvskfl asndsmcfsd gp
//
LOCUS       XP_047289276             692 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium/nucleoside cotransporter 1 isoform X1 [Homo sapiens].
ACCESSION   XP_047289276
VERSION     XP_047289276.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433320.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..692
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..692
                     /product="sodium/nucleoside cotransporter 1 isoform X1"
                     /calculated_mol_wt=76363
     Region          179..590
                     /region_name="nupC"
                     /note="nucleoside transporter; TIGR00804"
                     /db_xref="CDD:273278"
     CDS             1..692
                     /gene="SLC28A1"
                     /gene_synonym="CNT1; HCNT1; URCTU"
                     /coded_by="XM_047433320.1:52..2130"
                     /db_xref="GeneID:9154"
                     /db_xref="HGNC:HGNC:11001"
                     /db_xref="MIM:606207"
ORIGIN      
        1 mendpsrrre sisltpvakg lenmgadfle sleegqlprs dlspaeirss wseaapkpfs
       61 rwrnlqpalr arsfcrehmq lfrwigtgll ctglsafllv aclldfqral alfvltcvvl
      121 tflghrllkr llgpklrrfl kpqghprlll wfkrglalaa flglvlwlsl dtsqrpeqlv
      181 sfagicvfva llfacskhhc avswravswg lglqfvlgll virtepgfia fewlgeqiri
      241 flsytkagss fvfgealvkd vfafqvlpii vffscvisvl yhvglmqwvi lkiawlmqvt
      301 mgttatetls vagnifvsqt eapllirpyl admtlsevhv vmtggyatia gsllgayisf
      361 gidatsliaa svmaapcala lsklvypeve eskfrreegv kltygdaqnl ieaastgaai
      421 svkvvaniaa nliaflavld finaalswlg dmvdiqglsf qlicsyilrp vaflmgvawe
      481 dcpvvaellg iklflnefva yqdlskykqr rlagaeewvg drkqwisvra evlttfalcg
      541 fanfssigim lggltsmvpq rksdfsqivl ralftgacvs lvnacmagil ymprgaevdc
      601 msllnttlss ssfeiyqccr eafqrqcmsq eqvedeartq hggthfssts kkavthrsrl
      661 ptrwthemll htllhvskfl asndsmcfsd gp
//
LOCUS       XP_011520510             683 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium/nucleoside cotransporter 1 isoform X2 [Homo sapiens].
ACCESSION   XP_011520510
VERSION     XP_011520510.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522208.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..683
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..683
                     /product="sodium/nucleoside cotransporter 1 isoform X2"
                     /calculated_mol_wt=75601
     Region          170..581
                     /region_name="nupC"
                     /note="nucleoside transporter; TIGR00804"
                     /db_xref="CDD:273278"
     CDS             1..683
                     /gene="SLC28A1"
                     /gene_synonym="CNT1; HCNT1; URCTU"
                     /coded_by="XM_011522208.4:45..2096"
                     /db_xref="GeneID:9154"
                     /db_xref="HGNC:HGNC:11001"
                     /db_xref="MIM:606207"
ORIGIN      
        1 mccvpgfpld adrnkagrsg twrttprdee spslshlwpr vwrtwglisw kawrnlqpal
       61 rarsfcrehm qlfrwigtgl lctglsafll vaclldfqra lalfvltcvv ltflghrllk
      121 rllgpklrrf lkpqghprll lwfkrglala aflglvlwls ldtsqrpeql vsfagicvfv
      181 allfacskhh cavswravsw glglqfvlgl lvirtepgfi afewlgeqir iflsytkags
      241 sfvfgealvk dvfafqvlpi ivffscvisv lyhvglmqwv ilkiawlmqv tmgttatetl
      301 svagnifvsq teapllirpy ladmtlsevh vvmtggyati agsllgayis fgidatslia
      361 asvmaapcal alsklvypev eeskfrreeg vkltygdaqn lieaastgaa isvkvvania
      421 anliaflavl dfinaalswl gdmvdiqgls fqlicsyilr pvaflmgvaw edcpvvaell
      481 giklflnefv ayqdlskykq rrlagaeewv gdrkqwisvr aevlttfalc gfanfssigi
      541 mlggltsmvp qrksdfsqiv lralftgacv slvnacmagi lymprgaevd cmsllnttls
      601 sssfeiyqcc reafqrqcms qeqvedeart qhggthfsst skkavthrsr lptrwtheml
      661 lhtllhvskf lasndsmcfs dgp
//
LOCUS       XP_011520511             666 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium/nucleoside cotransporter 1 isoform X3 [Homo sapiens].
ACCESSION   XP_011520511
VERSION     XP_011520511.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522209.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..666
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..666
                     /product="sodium/nucleoside cotransporter 1 isoform X3"
                     /calculated_mol_wt=73509
     Region          179..564
                     /region_name="nupC"
                     /note="nucleoside transporter; TIGR00804"
                     /db_xref="CDD:273278"
     CDS             1..666
                     /gene="SLC28A1"
                     /gene_synonym="CNT1; HCNT1; URCTU"
                     /coded_by="XM_011522209.3:223..2223"
                     /db_xref="GeneID:9154"
                     /db_xref="HGNC:HGNC:11001"
                     /db_xref="MIM:606207"
ORIGIN      
        1 mendpsrrre sisltpvakg lenmgadfle sleegqlprs dlspaeirss wseaapkpfs
       61 rwrnlqpalr arsfcrehmq lfrwigtgll ctglsafllv aclldfqral alfvltcvvl
      121 tflghrllkr llgpklrrfl kpqghprlll wfkrglalaa flglvlwlsl dtsqrpeqlv
      181 sfagicvfva llfacskhhc avswravswg lglqfvlgll virtepgfia fewlgeqirv
      241 lpiivffscv isvlyhvglm qwvilkiawl mqvtmgttat etlsvagnif vsqteaplli
      301 rpyladmtls evhvvmtggy atiagsllga yisfgidats liaasvmaap calalsklvy
      361 peveeskfrr eegvkltygd aqnlieaast gaaisvkvva niaanliafl avldfinaal
      421 swlgdmvdiq glsfqlicsy ilrpvaflmg vawedcpvva ellgiklfln efvayqdlsk
      481 ykqrrlagae ewvgdrkqwi svraevlttf alcgfanfss igimlgglts mvpqrksdfs
      541 qivlralftg acvslvnacm agilymprga evdcmsllnt tlssssfeiy qccreafqrq
      601 cmsqeqvede artqhggthf sstskkavth rsrlptrwth emllhtllhv skflasndsm
      661 cfsdgp
//
LOCUS       XP_011520512             648 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium/nucleoside cotransporter 1 isoform X4 [Homo sapiens].
ACCESSION   XP_011520512
VERSION     XP_011520512.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522210.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..648
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..648
                     /product="sodium/nucleoside cotransporter 1 isoform X4"
                     /calculated_mol_wt=71429
     Region          179..590
                     /region_name="nupC"
                     /note="nucleoside transporter; TIGR00804"
                     /db_xref="CDD:273278"
     CDS             1..648
                     /gene="SLC28A1"
                     /gene_synonym="CNT1; HCNT1; URCTU"
                     /coded_by="XM_011522210.3:223..2169"
                     /db_xref="GeneID:9154"
                     /db_xref="HGNC:HGNC:11001"
                     /db_xref="MIM:606207"
ORIGIN      
        1 mendpsrrre sisltpvakg lenmgadfle sleegqlprs dlspaeirss wseaapkpfs
       61 rwrnlqpalr arsfcrehmq lfrwigtgll ctglsafllv aclldfqral alfvltcvvl
      121 tflghrllkr llgpklrrfl kpqghprlll wfkrglalaa flglvlwlsl dtsqrpeqlv
      181 sfagicvfva llfacskhhc avswravswg lglqfvlgll virtepgfia fewlgeqiri
      241 flsytkagss fvfgealvkd vfafqvlpii vffscvisvl yhvglmqwvi lkiawlmqvt
      301 mgttatetls vagnifvsqt eapllirpyl admtlsevhv vmtggyatia gsllgayisf
      361 gidatsliaa svmaapcala lsklvypeve eskfrreegv kltygdaqnl ieaastgaai
      421 svkvvaniaa nliaflavld finaalswlg dmvdiqglsf qlicsyilrp vaflmgvawe
      481 dcpvvaellg iklflnefva yqdlskykqr rlagaeewvg drkqwisvra evlttfalcg
      541 fanfssigim lggltsmvpq rksdfsqivl ralftgacvs lvnacmagil ymprgaevdc
      601 msllnttlss ssfeiyqccr eafqrqcmsq eqvedeartq hvgmqmgr
//
LOCUS       XP_016878212             633 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium/nucleoside cotransporter 1 isoform X5 [Homo sapiens].
ACCESSION   XP_016878212
VERSION     XP_016878212.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022723.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..633
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..633
                     /product="sodium/nucleoside cotransporter 1 isoform X5"
                     /calculated_mol_wt=69822
     Region          179..590
                     /region_name="nupC"
                     /note="nucleoside transporter; TIGR00804"
                     /db_xref="CDD:273278"
     CDS             1..633
                     /gene="SLC28A1"
                     /gene_synonym="CNT1; HCNT1; URCTU"
                     /coded_by="XM_017022723.2:223..2124"
                     /db_xref="GeneID:9154"
                     /db_xref="HGNC:HGNC:11001"
                     /db_xref="MIM:606207"
ORIGIN      
        1 mendpsrrre sisltpvakg lenmgadfle sleegqlprs dlspaeirss wseaapkpfs
       61 rwrnlqpalr arsfcrehmq lfrwigtgll ctglsafllv aclldfqral alfvltcvvl
      121 tflghrllkr llgpklrrfl kpqghprlll wfkrglalaa flglvlwlsl dtsqrpeqlv
      181 sfagicvfva llfacskhhc avswravswg lglqfvlgll virtepgfia fewlgeqiri
      241 flsytkagss fvfgealvkd vfafqvlpii vffscvisvl yhvglmqwvi lkiawlmqvt
      301 mgttatetls vagnifvsqt eapllirpyl admtlsevhv vmtggyatia gsllgayisf
      361 gidatsliaa svmaapcala lsklvypeve eskfrreegv kltygdaqnl ieaastgaai
      421 svkvvaniaa nliaflavld finaalswlg dmvdiqglsf qlicsyilrp vaflmgvawe
      481 dcpvvaellg iklflnefva yqdlskykqr rlagaeewvg drkqwisvra evlttfalcg
      541 fanfssigim lggltsmvpq rksdfsqivl ralftgacvs lvnacmagil ymprgaevdc
      601 msllnttlss ssfeiyqccr eafqrwdsfl iyk
//
LOCUS       XP_011520514             557 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium/nucleoside cotransporter 1 isoform X6 [Homo sapiens].
ACCESSION   XP_011520514
VERSION     XP_011520514.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522212.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..557
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..557
                     /product="sodium/nucleoside cotransporter 1 isoform X6"
                     /calculated_mol_wt=61706
     Region          179..512
                     /region_name="nupC"
                     /note="nucleoside transporter; TIGR00804"
                     /db_xref="CDD:273278"
     CDS             1..557
                     /gene="SLC28A1"
                     /gene_synonym="CNT1; HCNT1; URCTU"
                     /coded_by="XM_011522212.2:223..1896"
                     /db_xref="GeneID:9154"
                     /db_xref="HGNC:HGNC:11001"
                     /db_xref="MIM:606207"
ORIGIN      
        1 mendpsrrre sisltpvakg lenmgadfle sleegqlprs dlspaeirss wseaapkpfs
       61 rwrnlqpalr arsfcrehmq lfrwigtgll ctglsafllv aclldfqral alfvltcvvl
      121 tflghrllkr llgpklrrfl kpqghprlll wfkrglalaa flglvlwlsl dtsqrpeqlv
      181 sfagicvfva llfacskhhc avswravswg lglqfvlgll virtepgfia fewlgeqiri
      241 flsytkagss fvfgealvkd vfafqvlpii vffscvisvl yhvglmqwvi lkiawlmqvt
      301 mgttatetls vagnifvsqt eapllirpyl admtlsevhv vmtggyatia gsllgayisf
      361 gidatsliaa svmaapcala lsklvypeve eskfrreegv kltygdaqnl ieaastgaai
      421 svkvvaniaa nliaflavld finaalswlg dmvdiqglsf qlicsyilrp vaflmgvawe
      481 dcpvvaellg iklflnefva yqdlskykqr rlagaeewvg drkqwislec rwegeqawtm
      541 ktkatperws sfklkga
//
LOCUS       XP_011520516             537 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium/nucleoside cotransporter 1 isoform X7 [Homo sapiens].
ACCESSION   XP_011520516
VERSION     XP_011520516.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522214.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..537
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..537
                     /product="sodium/nucleoside cotransporter 1 isoform X7"
                     /calculated_mol_wt=59081
     Region          179..512
                     /region_name="nupC"
                     /note="nucleoside transporter; TIGR00804"
                     /db_xref="CDD:273278"
     CDS             1..537
                     /gene="SLC28A1"
                     /gene_synonym="CNT1; HCNT1; URCTU"
                     /coded_by="XM_011522214.3:223..1836"
                     /db_xref="GeneID:9154"
                     /db_xref="HGNC:HGNC:11001"
                     /db_xref="MIM:606207"
ORIGIN      
        1 mendpsrrre sisltpvakg lenmgadfle sleegqlprs dlspaeirss wseaapkpfs
       61 rwrnlqpalr arsfcrehmq lfrwigtgll ctglsafllv aclldfqral alfvltcvvl
      121 tflghrllkr llgpklrrfl kpqghprlll wfkrglalaa flglvlwlsl dtsqrpeqlv
      181 sfagicvfva llfacskhhc avswravswg lglqfvlgll virtepgfia fewlgeqiri
      241 flsytkagss fvfgealvkd vfafqvlpii vffscvisvl yhvglmqwvi lkiawlmqvt
      301 mgttatetls vagnifvsqt eapllirpyl admtlsevhv vmtggyatia gsllgayisf
      361 gidatsliaa svmaapcala lsklvypeve eskfrreegv kltygdaqnl ieaastgaai
      421 svkvvaniaa nliaflavld finaalswlg dmvdiqglsf qlicsyilrp vaflmgvawe
      481 dcpvvaellg iklflnefva yqdlskykqr rlagaeewvg drkqwisiis aafpgvg
//
LOCUS       XP_011520517             526 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium/nucleoside cotransporter 1 isoform X8 [Homo sapiens].
ACCESSION   XP_011520517
VERSION     XP_011520517.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522215.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..526
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..526
                     /product="sodium/nucleoside cotransporter 1 isoform X8"
                     /calculated_mol_wt=58265
     Region          179..424
                     /region_name="nupC"
                     /note="nucleoside transporter; TIGR00804"
                     /db_xref="CDD:273278"
     CDS             1..526
                     /gene="SLC28A1"
                     /gene_synonym="CNT1; HCNT1; URCTU"
                     /coded_by="XM_011522215.3:223..1803"
                     /db_xref="GeneID:9154"
                     /db_xref="HGNC:HGNC:11001"
                     /db_xref="MIM:606207"
ORIGIN      
        1 mendpsrrre sisltpvakg lenmgadfle sleegqlprs dlspaeirss wseaapkpfs
       61 rwrnlqpalr arsfcrehmq lfrwigtgll ctglsafllv aclldfqral alfvltcvvl
      121 tflghrllkr llgpklrrfl kpqghprlll wfkrglalaa flglvlwlsl dtsqrpeqlv
      181 sfagicvfva llfacskhhc avswravswg lglqfvlgll virtepgfia fewlgeqiri
      241 flsytkagss fvfgealvkd vfafqvlpii vffscvisvl yhvglmqwvi lkiawlmqvt
      301 mgttatetls vagnifvsqt eapllirpyl admtlsevhv vmtggyatia gsllgayisf
      361 gvraevlttf alcgfanfss igimlgglts mvpqrksdfs qivlralftg acvslvnacm
      421 agilymprga evdcmsllnt tlssssfeiy qccreafqrq cmsqeqvede artqhggthf
      481 sstskkavth rsrlptrwth emllhtllhv skflasndsm cfsdgp
//
LOCUS       XP_011520519             483 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium/nucleoside cotransporter 1 isoform X9 [Homo sapiens].
ACCESSION   XP_011520519
VERSION     XP_011520519.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522217.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..483
                     /product="sodium/nucleoside cotransporter 1 isoform X9"
                     /calculated_mol_wt=53355
     Region          179..424
                     /region_name="nupC"
                     /note="nucleoside transporter; TIGR00804"
                     /db_xref="CDD:273278"
     CDS             1..483
                     /gene="SLC28A1"
                     /gene_synonym="CNT1; HCNT1; URCTU"
                     /coded_by="XM_011522217.2:223..1674"
                     /db_xref="GeneID:9154"
                     /db_xref="HGNC:HGNC:11001"
                     /db_xref="MIM:606207"
ORIGIN      
        1 mendpsrrre sisltpvakg lenmgadfle sleegqlprs dlspaeirss wseaapkpfs
       61 rwrnlqpalr arsfcrehmq lfrwigtgll ctglsafllv aclldfqral alfvltcvvl
      121 tflghrllkr llgpklrrfl kpqghprlll wfkrglalaa flglvlwlsl dtsqrpeqlv
      181 sfagicvfva llfacskhhc avswravswg lglqfvlgll virtepgfia fewlgeqiri
      241 flsytkagss fvfgealvkd vfafqvlpii vffscvisvl yhvglmqwvi lkiawlmqvt
      301 mgttatetls vagnifvsqt eapllirpyl admtlsevhv vmtggyatia gsllgayisf
      361 gvraevlttf alcgfanfss igimlgglts mvpqrksdfs qivlralftg acvslvnacm
      421 agilymprga evdcmsllnt tlssssfeiy qccreafqsv npefspeald nccrfynhti
      481 caq
//
LOCUS       XP_011520518             614 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium/nucleoside cotransporter 1 isoform X10 [Homo sapiens].
ACCESSION   XP_011520518
VERSION     XP_011520518.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522216.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..614
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..614
                     /product="sodium/nucleoside cotransporter 1 isoform X10"
                     /calculated_mol_wt=67484
     Region          101..512
                     /region_name="nupC"
                     /note="nucleoside transporter; TIGR00804"
                     /db_xref="CDD:273278"
     CDS             1..614
                     /gene="SLC28A1"
                     /gene_synonym="CNT1; HCNT1; URCTU"
                     /coded_by="XM_011522216.2:197..2041"
                     /db_xref="GeneID:9154"
                     /db_xref="HGNC:HGNC:11001"
                     /db_xref="MIM:606207"
ORIGIN      
        1 mqlfrwigtg llctglsafl lvaclldfqr alalfvltcv vltflghrll krllgpklrr
       61 flkpqghprl llwfkrglal aaflglvlwl sldtsqrpeq lvsfagicvf vallfacskh
      121 hcavswravs wglglqfvlg llvirtepgf iafewlgeqi riflsytkag ssfvfgealv
      181 kdvfafqvlp iivffscvis vlyhvglmqw vilkiawlmq vtmgttatet lsvagnifvs
      241 qteapllirp yladmtlsev hvvmtggyat iagsllgayi sfgidatsli aasvmaapca
      301 lalsklvype veeskfrree gvkltygdaq nlieaastga aisvkvvani aanliaflav
      361 ldfinaalsw lgdmvdiqgl sfqlicsyil rpvaflmgva wedcpvvael lgiklflnef
      421 vayqdlskyk qrrlagaeew vgdrkqwisv raevlttfal cgfanfssig imlggltsmv
      481 pqrksdfsqi vlralftgac vslvnacmag ilymprgaev dcmsllnttl ssssfeiyqc
      541 creafqrqcm sqeqvedear tqhggthfss tskkavthrs rlptrwthem llhtllhvsk
      601 flasndsmcf sdgp
//
LOCUS       XP_047289278             442 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium/nucleoside cotransporter 1 isoform X11 [Homo sapiens].
ACCESSION   XP_047289278
VERSION     XP_047289278.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433322.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..442
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..442
                     /product="sodium/nucleoside cotransporter 1 isoform X11"
                     /calculated_mol_wt=48630
     Region          179..>365
                     /region_name="nupC"
                     /note="nucleoside transporter; TIGR00804"
                     /db_xref="CDD:273278"
     CDS             1..442
                     /gene="SLC28A1"
                     /gene_synonym="CNT1; HCNT1; URCTU"
                     /coded_by="XM_047433322.1:223..1551"
                     /db_xref="GeneID:9154"
                     /db_xref="HGNC:HGNC:11001"
                     /db_xref="MIM:606207"
ORIGIN      
        1 mendpsrrre sisltpvakg lenmgadfle sleegqlprs dlspaeirss wseaapkpfs
       61 rwrnlqpalr arsfcrehmq lfrwigtgll ctglsafllv aclldfqral alfvltcvvl
      121 tflghrllkr llgpklrrfl kpqghprlll wfkrglalaa flglvlwlsl dtsqrpeqlv
      181 sfagicvfva llfacskhhc avswravswg lglqfvlgll virtepgfia fewlgeqiri
      241 flsytkagss fvfgealvkd vfafqvlpii vffscvisvl yhvglmqwvi lkiawlmqvt
      301 mgttatetls vagnifvsqt eapllirpyl admtlsevhv vmtggyatia gsllgayisf
      361 grcsephrss qhwgrhlreg grqhrcqpdc vpgcaglyqc cpllagrhgg hpraqlpahl
      421 llhpaacsll dgcgvgglps gs
//
LOCUS       XP_011520520             365 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium/nucleoside cotransporter 1 isoform X12 [Homo sapiens].
ACCESSION   XP_011520520
VERSION     XP_011520520.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522218.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..365
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..365
                     /product="sodium/nucleoside cotransporter 1 isoform X12"
                     /calculated_mol_wt=40553
     Region          179..>363
                     /region_name="nupC"
                     /note="nucleoside transporter; TIGR00804"
                     /db_xref="CDD:273278"
     CDS             1..365
                     /gene="SLC28A1"
                     /gene_synonym="CNT1; HCNT1; URCTU"
                     /coded_by="XM_011522218.3:223..1320"
                     /db_xref="GeneID:9154"
                     /db_xref="HGNC:HGNC:11001"
                     /db_xref="MIM:606207"
ORIGIN      
        1 mendpsrrre sisltpvakg lenmgadfle sleegqlprs dlspaeirss wseaapkpfs
       61 rwrnlqpalr arsfcrehmq lfrwigtgll ctglsafllv aclldfqral alfvltcvvl
      121 tflghrllkr llgpklrrfl kpqghprlll wfkrglalaa flglvlwlsl dtsqrpeqlv
      181 sfagicvfva llfacskhhc avswravswg lglqfvlgll virtepgfia fewlgeqiri
      241 flsytkagss fvfgealvkd vfafqvlpii vffscvisvl yhvglmqwvi lkiawlmqvt
      301 mgttatetls vagnifvsqt eapllirpyl admtlsevhv vmtggyatia gsllgayisf
      361 glekl
//
LOCUS       XP_011520521            1099 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium/potassium/calcium exchanger 1 isoform X1 [Homo sapiens].
ACCESSION   XP_011520521
VERSION     XP_011520521.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522219.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1099
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1099
                     /product="sodium/potassium/calcium exchanger 1 isoform X1"
                     /calculated_mol_wt=121244
     Region          1..1099
                     /region_name="2A1904"
                     /note="K+-dependent Na+/Ca+ exchanger; TIGR00927"
                     /db_xref="CDD:273344"
     CDS             1..1099
                     /gene="SLC24A1"
                     /gene_synonym="CSNB1D; HsT17412; NCKX; NCKX1; RODX"
                     /coded_by="XM_011522219.2:781..4080"
                     /db_xref="GeneID:9187"
                     /db_xref="HGNC:HGNC:10975"
                     /db_xref="MIM:603617"
ORIGIN      
        1 mgklirmgpq erwllrtkrl hwsrllfllg mliigstyqh lrrprglssl waavsshqpi
       61 klasrdlsse emmmmsssps kpssemggkm lvpqasvgsd eatlsmtven ipsmpkrtak
      121 miptttknny sptaagterr kedtptssrt ltyytstssr qivkkytptp rgemksyspt
      181 qvrekvkytp sprgrrvgty vpstfmtmet shaitprttv kdsditatyk iletnslkri
      241 meettpttlk gmfdstptfl theveanvlt sprsvmeknn lfpprrvesn ssahpwglvg
      301 ksnpktpqgt vllhtpatse gqvtistmtg sspaetkaft aawslrnpsp rtsvsaikta
      361 paivwrlakk pstapststt ptvrakltmq vhhcvvvkpt pamlttpsps lttallpeel
      421 spspsvlpps lpdlhpkgey ppdlfsveer rqgwvvlhvf gmmyvfvala ivcdeyfvpa
      481 lgvitdklqi sedvagatfm aaggsapelf tsligvfish snvgigtivg savfnilfvi
      541 gtcslfsrei lnltwwplfr dvsfyildli mlilffldsl iawwesllll layafyvftm
      601 kwnkhievwv keqlsrrpva kvmaledlsk pgdgaiavde lqdnkklklp slltrgssst
      661 slhnstirst iyqlmlhsld plrevrlake keeeslnqga raqpqakaes kpeeeepakl
      721 pavtvtpapv pdikgdqken pggqedvaea estgempgee getagegete eksggetqpe
      781 gegetetqgk geecedenea egkgdneged egeihaedge mkgnegetes qelsaenhge
      841 akndekgved gggsdggdse eeeeeeeeqe eeeeeeeqee eeeeeeeeee kgneeplsld
      901 wpetrqkqai ylfllpivfp lwltvpdvrr qesrkffvft flgsimwiam fsylmvwwah
      961 qvgetigise eimgltilaa gtsipdlits vivarkglgd mavsssvgsn ifditvglpv
     1021 pwllfsling lqpvpvssng lfcaivllfl mllfvissia sckwrmnkil gftmfllyfv
     1081 fliisvmled riiscpvsv
//
LOCUS       XP_024305871            1099 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium/potassium/calcium exchanger 1 isoform X1 [Homo sapiens].
ACCESSION   XP_024305871
VERSION     XP_024305871.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024450103.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1099
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1099
                     /product="sodium/potassium/calcium exchanger 1 isoform X1"
                     /calculated_mol_wt=121244
     Region          1..1099
                     /region_name="2A1904"
                     /note="K+-dependent Na+/Ca+ exchanger; TIGR00927"
                     /db_xref="CDD:273344"
     CDS             1..1099
                     /gene="SLC24A1"
                     /gene_synonym="CSNB1D; HsT17412; NCKX; NCKX1; RODX"
                     /coded_by="XM_024450103.2:965..4264"
                     /db_xref="GeneID:9187"
                     /db_xref="HGNC:HGNC:10975"
                     /db_xref="MIM:603617"
ORIGIN      
        1 mgklirmgpq erwllrtkrl hwsrllfllg mliigstyqh lrrprglssl waavsshqpi
       61 klasrdlsse emmmmsssps kpssemggkm lvpqasvgsd eatlsmtven ipsmpkrtak
      121 miptttknny sptaagterr kedtptssrt ltyytstssr qivkkytptp rgemksyspt
      181 qvrekvkytp sprgrrvgty vpstfmtmet shaitprttv kdsditatyk iletnslkri
      241 meettpttlk gmfdstptfl theveanvlt sprsvmeknn lfpprrvesn ssahpwglvg
      301 ksnpktpqgt vllhtpatse gqvtistmtg sspaetkaft aawslrnpsp rtsvsaikta
      361 paivwrlakk pstapststt ptvrakltmq vhhcvvvkpt pamlttpsps lttallpeel
      421 spspsvlpps lpdlhpkgey ppdlfsveer rqgwvvlhvf gmmyvfvala ivcdeyfvpa
      481 lgvitdklqi sedvagatfm aaggsapelf tsligvfish snvgigtivg savfnilfvi
      541 gtcslfsrei lnltwwplfr dvsfyildli mlilffldsl iawwesllll layafyvftm
      601 kwnkhievwv keqlsrrpva kvmaledlsk pgdgaiavde lqdnkklklp slltrgssst
      661 slhnstirst iyqlmlhsld plrevrlake keeeslnqga raqpqakaes kpeeeepakl
      721 pavtvtpapv pdikgdqken pggqedvaea estgempgee getagegete eksggetqpe
      781 gegetetqgk geecedenea egkgdneged egeihaedge mkgnegetes qelsaenhge
      841 akndekgved gggsdggdse eeeeeeeeqe eeeeeeeqee eeeeeeeeee kgneeplsld
      901 wpetrqkqai ylfllpivfp lwltvpdvrr qesrkffvft flgsimwiam fsylmvwwah
      961 qvgetigise eimgltilaa gtsipdlits vivarkglgd mavsssvgsn ifditvglpv
     1021 pwllfsling lqpvpvssng lfcaivllfl mllfvissia sckwrmnkil gftmfllyfv
     1081 fliisvmled riiscpvsv
//
LOCUS       XP_024305872            1099 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium/potassium/calcium exchanger 1 isoform X1 [Homo sapiens].
ACCESSION   XP_024305872
VERSION     XP_024305872.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024450104.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1099
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1099
                     /product="sodium/potassium/calcium exchanger 1 isoform X1"
                     /calculated_mol_wt=121244
     Region          1..1099
                     /region_name="2A1904"
                     /note="K+-dependent Na+/Ca+ exchanger; TIGR00927"
                     /db_xref="CDD:273344"
     CDS             1..1099
                     /gene="SLC24A1"
                     /gene_synonym="CSNB1D; HsT17412; NCKX; NCKX1; RODX"
                     /coded_by="XM_024450104.2:780..4079"
                     /db_xref="GeneID:9187"
                     /db_xref="HGNC:HGNC:10975"
                     /db_xref="MIM:603617"
ORIGIN      
        1 mgklirmgpq erwllrtkrl hwsrllfllg mliigstyqh lrrprglssl waavsshqpi
       61 klasrdlsse emmmmsssps kpssemggkm lvpqasvgsd eatlsmtven ipsmpkrtak
      121 miptttknny sptaagterr kedtptssrt ltyytstssr qivkkytptp rgemksyspt
      181 qvrekvkytp sprgrrvgty vpstfmtmet shaitprttv kdsditatyk iletnslkri
      241 meettpttlk gmfdstptfl theveanvlt sprsvmeknn lfpprrvesn ssahpwglvg
      301 ksnpktpqgt vllhtpatse gqvtistmtg sspaetkaft aawslrnpsp rtsvsaikta
      361 paivwrlakk pstapststt ptvrakltmq vhhcvvvkpt pamlttpsps lttallpeel
      421 spspsvlpps lpdlhpkgey ppdlfsveer rqgwvvlhvf gmmyvfvala ivcdeyfvpa
      481 lgvitdklqi sedvagatfm aaggsapelf tsligvfish snvgigtivg savfnilfvi
      541 gtcslfsrei lnltwwplfr dvsfyildli mlilffldsl iawwesllll layafyvftm
      601 kwnkhievwv keqlsrrpva kvmaledlsk pgdgaiavde lqdnkklklp slltrgssst
      661 slhnstirst iyqlmlhsld plrevrlake keeeslnqga raqpqakaes kpeeeepakl
      721 pavtvtpapv pdikgdqken pggqedvaea estgempgee getagegete eksggetqpe
      781 gegetetqgk geecedenea egkgdneged egeihaedge mkgnegetes qelsaenhge
      841 akndekgved gggsdggdse eeeeeeeeqe eeeeeeeqee eeeeeeeeee kgneeplsld
      901 wpetrqkqai ylfllpivfp lwltvpdvrr qesrkffvft flgsimwiam fsylmvwwah
      961 qvgetigise eimgltilaa gtsipdlits vivarkglgd mavsssvgsn ifditvglpv
     1021 pwllfsling lqpvpvssng lfcaivllfl mllfvissia sckwrmnkil gftmfllyfv
     1081 fliisvmled riiscpvsv
//
LOCUS       XP_024305873            1099 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium/potassium/calcium exchanger 1 isoform X1 [Homo sapiens].
ACCESSION   XP_024305873
VERSION     XP_024305873.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_024450105.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1099
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1099
                     /product="sodium/potassium/calcium exchanger 1 isoform X1"
                     /calculated_mol_wt=121244
     Region          1..1099
                     /region_name="2A1904"
                     /note="K+-dependent Na+/Ca+ exchanger; TIGR00927"
                     /db_xref="CDD:273344"
     CDS             1..1099
                     /gene="SLC24A1"
                     /gene_synonym="CSNB1D; HsT17412; NCKX; NCKX1; RODX"
                     /coded_by="XM_024450105.2:798..4097"
                     /db_xref="GeneID:9187"
                     /db_xref="HGNC:HGNC:10975"
                     /db_xref="MIM:603617"
ORIGIN      
        1 mgklirmgpq erwllrtkrl hwsrllfllg mliigstyqh lrrprglssl waavsshqpi
       61 klasrdlsse emmmmsssps kpssemggkm lvpqasvgsd eatlsmtven ipsmpkrtak
      121 miptttknny sptaagterr kedtptssrt ltyytstssr qivkkytptp rgemksyspt
      181 qvrekvkytp sprgrrvgty vpstfmtmet shaitprttv kdsditatyk iletnslkri
      241 meettpttlk gmfdstptfl theveanvlt sprsvmeknn lfpprrvesn ssahpwglvg
      301 ksnpktpqgt vllhtpatse gqvtistmtg sspaetkaft aawslrnpsp rtsvsaikta
      361 paivwrlakk pstapststt ptvrakltmq vhhcvvvkpt pamlttpsps lttallpeel
      421 spspsvlpps lpdlhpkgey ppdlfsveer rqgwvvlhvf gmmyvfvala ivcdeyfvpa
      481 lgvitdklqi sedvagatfm aaggsapelf tsligvfish snvgigtivg savfnilfvi
      541 gtcslfsrei lnltwwplfr dvsfyildli mlilffldsl iawwesllll layafyvftm
      601 kwnkhievwv keqlsrrpva kvmaledlsk pgdgaiavde lqdnkklklp slltrgssst
      661 slhnstirst iyqlmlhsld plrevrlake keeeslnqga raqpqakaes kpeeeepakl
      721 pavtvtpapv pdikgdqken pggqedvaea estgempgee getagegete eksggetqpe
      781 gegetetqgk geecedenea egkgdneged egeihaedge mkgnegetes qelsaenhge
      841 akndekgved gggsdggdse eeeeeeeeqe eeeeeeeqee eeeeeeeeee kgneeplsld
      901 wpetrqkqai ylfllpivfp lwltvpdvrr qesrkffvft flgsimwiam fsylmvwwah
      961 qvgetigise eimgltilaa gtsipdlits vivarkglgd mavsssvgsn ifditvglpv
     1021 pwllfsling lqpvpvssng lfcaivllfl mllfvissia sckwrmnkil gftmfllyfv
     1081 fliisvmled riiscpvsv
//
LOCUS       XP_047289281            1081 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium/potassium/calcium exchanger 1 isoform X2 [Homo sapiens].
ACCESSION   XP_047289281
VERSION     XP_047289281.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433325.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1081
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1081
                     /product="sodium/potassium/calcium exchanger 1 isoform X2"
                     /calculated_mol_wt=119350
     Region          1..1081
                     /region_name="2A1904"
                     /note="K+-dependent Na+/Ca+ exchanger; TIGR00927"
                     /db_xref="CDD:273344"
     CDS             1..1081
                     /gene="SLC24A1"
                     /gene_synonym="CSNB1D; HsT17412; NCKX; NCKX1; RODX"
                     /coded_by="XM_047433325.1:798..4043"
                     /db_xref="GeneID:9187"
                     /db_xref="HGNC:HGNC:10975"
                     /db_xref="MIM:603617"
ORIGIN      
        1 mgklirmgpq erwllrtkrl hwsrllfllg mliigstyqh lrrprglssl waavsshqpi
       61 klasrdlsse emmmmsssps kpssemggkm lvpqasvgsd eatlsmtven ipsmpkrtak
      121 miptttknny sptaagterr kedtptssrt ltyytstssr qivkkytptp rgemksyspt
      181 qvrekvkytp sprgrrvgty vpstfmtmet shaitprttv kdsditatyk iletnslkri
      241 meettpttlk gmfdstptfl theveanvlt sprsvmeknn lfpprrvesn ssahpwglvg
      301 ksnpktpqgt vllhtpatse gqvtistmtg sspaetkaft aawslrnpsp rtsvsaikta
      361 paivwrlakk pstapststt ptvrakltmq vhhcvvvkpt pamlttpsps lttallpeel
      421 spspsvlpps lpdlhpkgey ppdlfsveer rqgwvvlhvf gmmyvfvala ivcdeyfvpa
      481 lgvitdklqi sedvagatfm aaggsapelf tsligvfish snvgigtivg savfnilfvi
      541 gtcslfsrei lnltwwplfr dvsfyildli mlilffldsl iawwesllll layafyvftm
      601 kwnkhievwv keqlsrrpva kvmaledlsk lpslltrgss stslhnstir stiyqlmlhs
      661 ldplrevrla kekeeeslnq garaqpqaka eskpeeeepa klpavtvtpa pvpdikgdqk
      721 enpggqedva eaestgempg eegetagege teeksggetq pegegetetq gkgeeceden
      781 eaegkgdneg edegeihaed gemkgneget esqelsaenh geakndekgv edgggsdggd
      841 seeeeeeeee qeeeeeeeeq eeeeeeeeee eekgneepls ldwpetrqkq aiylfllpiv
      901 fplwltvpdv rrqesrkffv ftflgsimwi amfsylmvww ahqvgetigi seeimgltil
      961 aagtsipdli tsvivarkgl gdmavsssvg snifditvgl pvpwllfsli nglqpvpvss
     1021 nglfcaivll flmllfviss iasckwrmnk ilgftmflly fvfliisvml edriiscpvs
     1081 v
//
LOCUS       XP_047289282            1081 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium/potassium/calcium exchanger 1 isoform X2 [Homo sapiens].
ACCESSION   XP_047289282
VERSION     XP_047289282.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433326.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1081
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1081
                     /product="sodium/potassium/calcium exchanger 1 isoform X2"
                     /calculated_mol_wt=119350
     Region          1..1081
                     /region_name="2A1904"
                     /note="K+-dependent Na+/Ca+ exchanger; TIGR00927"
                     /db_xref="CDD:273344"
     CDS             1..1081
                     /gene="SLC24A1"
                     /gene_synonym="CSNB1D; HsT17412; NCKX; NCKX1; RODX"
                     /coded_by="XM_047433326.1:356..3601"
                     /db_xref="GeneID:9187"
                     /db_xref="HGNC:HGNC:10975"
                     /db_xref="MIM:603617"
ORIGIN      
        1 mgklirmgpq erwllrtkrl hwsrllfllg mliigstyqh lrrprglssl waavsshqpi
       61 klasrdlsse emmmmsssps kpssemggkm lvpqasvgsd eatlsmtven ipsmpkrtak
      121 miptttknny sptaagterr kedtptssrt ltyytstssr qivkkytptp rgemksyspt
      181 qvrekvkytp sprgrrvgty vpstfmtmet shaitprttv kdsditatyk iletnslkri
      241 meettpttlk gmfdstptfl theveanvlt sprsvmeknn lfpprrvesn ssahpwglvg
      301 ksnpktpqgt vllhtpatse gqvtistmtg sspaetkaft aawslrnpsp rtsvsaikta
      361 paivwrlakk pstapststt ptvrakltmq vhhcvvvkpt pamlttpsps lttallpeel
      421 spspsvlpps lpdlhpkgey ppdlfsveer rqgwvvlhvf gmmyvfvala ivcdeyfvpa
      481 lgvitdklqi sedvagatfm aaggsapelf tsligvfish snvgigtivg savfnilfvi
      541 gtcslfsrei lnltwwplfr dvsfyildli mlilffldsl iawwesllll layafyvftm
      601 kwnkhievwv keqlsrrpva kvmaledlsk lpslltrgss stslhnstir stiyqlmlhs
      661 ldplrevrla kekeeeslnq garaqpqaka eskpeeeepa klpavtvtpa pvpdikgdqk
      721 enpggqedva eaestgempg eegetagege teeksggetq pegegetetq gkgeeceden
      781 eaegkgdneg edegeihaed gemkgneget esqelsaenh geakndekgv edgggsdggd
      841 seeeeeeeee qeeeeeeeeq eeeeeeeeee eekgneepls ldwpetrqkq aiylfllpiv
      901 fplwltvpdv rrqesrkffv ftflgsimwi amfsylmvww ahqvgetigi seeimgltil
      961 aagtsipdli tsvivarkgl gdmavsssvg snifditvgl pvpwllfsli nglqpvpvss
     1021 nglfcaivll flmllfviss iasckwrmnk ilgftmflly fvfliisvml edriiscpvs
     1081 v
//
LOCUS       XP_011520523            1069 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium/potassium/calcium exchanger 1 isoform X3 [Homo sapiens].
ACCESSION   XP_011520523
VERSION     XP_011520523.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522221.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1069
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1069
                     /product="sodium/potassium/calcium exchanger 1 isoform X3"
                     /calculated_mol_wt=117501
     Region          1..1069
                     /region_name="2A1904"
                     /note="K+-dependent Na+/Ca+ exchanger; TIGR00927"
                     /db_xref="CDD:273344"
     CDS             1..1069
                     /gene="SLC24A1"
                     /gene_synonym="CSNB1D; HsT17412; NCKX; NCKX1; RODX"
                     /coded_by="XM_011522221.4:262..3471"
                     /db_xref="GeneID:9187"
                     /db_xref="HGNC:HGNC:10975"
                     /db_xref="MIM:603617"
ORIGIN      
        1 mgklirmgpq erwllrtkrl hwsrllfllg mliigstyqh lrrprglssl waavsshqpi
       61 klasrdlsse emmmmsssps kpssemggkm lvpqasvgsd eatlsmtven ipsmpkrtak
      121 miptttknny sptaagterr kedtptssrt ltyytstssr qivkkytptp rgemksyspt
      181 qvrekvkytp sprgrrvgty vpstfmtmet shaitprttv kdsditatyk iletnslkri
      241 meettpttlk gmfdstptfl theveanvlt sprsvmeknn lfpprrvesn ssahpwglvg
      301 ksnpktpqgt vllhtpatse gqvtistmtg sspaetkaft aawslrnpsp rtsvsaikta
      361 paivwrlakk pstapststt ptvrakltmq vhhcvvvkpt pamlttpsps lttallpeel
      421 spspsvlpps lpdlhpkgey ppdlfsveer rqgwvvlhvf gmmyvfvala ivcdeyfvpa
      481 lgvitdklqi sedvagatfm aaggsapelf tsligvfish snvgigtivg savfnilfvi
      541 gtcslfsrei lnltwwplfr dvsfyildli mlilffldsl iawwesllll layafyvftm
      601 kwnkhievwv keqlsrrpva kvmaledlsk pgdgaiavde lqdnkklklp slltrgssst
      661 slhnstirst iyqlmlhsld plrevrlake keeeslnqga raqpqakaes kpeeeepakl
      721 pavtvtpapv pdikgdqken pggqedvaea estgempgee getagegete eksggetqpe
      781 gegetetqgk geecedenea egkgdneged egeihaedge mkgnegetes qelsaenhge
      841 akndekgved gggsdggdse eeeeeeeeqe eeeeeeeqee eeeeeeeeee kgneeplsld
      901 wpetrqkqai ylfllpivfp lwltvpdvrr qvgetigise eimgltilaa gtsipdlits
      961 vivarkglgd mavsssvgsn ifditvglpv pwllfsling lqpvpvssng lfcaivllfl
     1021 mllfvissia sckwrmnkil gftmfllyfv fliisvmled riiscpvsv
//
LOCUS       XP_047289283            1051 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium/potassium/calcium exchanger 1 isoform X4 [Homo sapiens].
ACCESSION   XP_047289283
VERSION     XP_047289283.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433327.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1051
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1051
                     /product="sodium/potassium/calcium exchanger 1 isoform X4"
                     /calculated_mol_wt=115608
     Region          1..1051
                     /region_name="2A1904"
                     /note="K+-dependent Na+/Ca+ exchanger; TIGR00927"
                     /db_xref="CDD:273344"
     CDS             1..1051
                     /gene="SLC24A1"
                     /gene_synonym="CSNB1D; HsT17412; NCKX; NCKX1; RODX"
                     /coded_by="XM_047433327.1:262..3417"
                     /db_xref="GeneID:9187"
                     /db_xref="HGNC:HGNC:10975"
                     /db_xref="MIM:603617"
ORIGIN      
        1 mgklirmgpq erwllrtkrl hwsrllfllg mliigstyqh lrrprglssl waavsshqpi
       61 klasrdlsse emmmmsssps kpssemggkm lvpqasvgsd eatlsmtven ipsmpkrtak
      121 miptttknny sptaagterr kedtptssrt ltyytstssr qivkkytptp rgemksyspt
      181 qvrekvkytp sprgrrvgty vpstfmtmet shaitprttv kdsditatyk iletnslkri
      241 meettpttlk gmfdstptfl theveanvlt sprsvmeknn lfpprrvesn ssahpwglvg
      301 ksnpktpqgt vllhtpatse gqvtistmtg sspaetkaft aawslrnpsp rtsvsaikta
      361 paivwrlakk pstapststt ptvrakltmq vhhcvvvkpt pamlttpsps lttallpeel
      421 spspsvlpps lpdlhpkgey ppdlfsveer rqgwvvlhvf gmmyvfvala ivcdeyfvpa
      481 lgvitdklqi sedvagatfm aaggsapelf tsligvfish snvgigtivg savfnilfvi
      541 gtcslfsrei lnltwwplfr dvsfyildli mlilffldsl iawwesllll layafyvftm
      601 kwnkhievwv keqlsrrpva kvmaledlsk lpslltrgss stslhnstir stiyqlmlhs
      661 ldplrevrla kekeeeslnq garaqpqaka eskpeeeepa klpavtvtpa pvpdikgdqk
      721 enpggqedva eaestgempg eegetagege teeksggetq pegegetetq gkgeeceden
      781 eaegkgdneg edegeihaed gemkgneget esqelsaenh geakndekgv edgggsdggd
      841 seeeeeeeee qeeeeeeeeq eeeeeeeeee eekgneepls ldwpetrqkq aiylfllpiv
      901 fplwltvpdv rrqvgetigi seeimgltil aagtsipdli tsvivarkgl gdmavsssvg
      961 snifditvgl pvpwllfsli nglqpvpvss nglfcaivll flmllfviss iasckwrmnk
     1021 ilgftmflly fvfliisvml edriiscpvs v
//
LOCUS       XP_016878213            1049 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium/potassium/calcium exchanger 1 isoform X5 [Homo sapiens].
ACCESSION   XP_016878213
VERSION     XP_016878213.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022724.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1049
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1049
                     /product="sodium/potassium/calcium exchanger 1 isoform X5"
                     /calculated_mol_wt=115351
     Region          1..1022
                     /region_name="2A1904"
                     /note="K+-dependent Na+/Ca+ exchanger; TIGR00927"
                     /db_xref="CDD:273344"
     CDS             1..1049
                     /gene="SLC24A1"
                     /gene_synonym="CSNB1D; HsT17412; NCKX; NCKX1; RODX"
                     /coded_by="XM_017022724.3:262..3411"
                     /db_xref="GeneID:9187"
                     /db_xref="HGNC:HGNC:10975"
                     /db_xref="MIM:603617"
ORIGIN      
        1 mgklirmgpq erwllrtkrl hwsrllfllg mliigstyqh lrrprglssl waavsshqpi
       61 klasrdlsse emmmmsssps kpssemggkm lvpqasvgsd eatlsmtven ipsmpkrtak
      121 miptttknny sptaagterr kedtptssrt ltyytstssr qivkkytptp rgemksyspt
      181 qvrekvkytp sprgrrvgty vpstfmtmet shaitprttv kdsditatyk iletnslkri
      241 meettpttlk gmfdstptfl theveanvlt sprsvmeknn lfpprrvesn ssahpwglvg
      301 ksnpktpqgt vllhtpatse gqvtistmtg sspaetkaft aawslrnpsp rtsvsaikta
      361 paivwrlakk pstapststt ptvrakltmq vhhcvvvkpt pamlttpsps lttallpeel
      421 spspsvlpps lpdlhpkgey ppdlfsveer rqgwvvlhvf gmmyvfvala ivcdeyfvpa
      481 lgvitdklqi sedvagatfm aaggsapelf tsligvfish snvgigtivg savfnilfvi
      541 gtcslfsrei lnltwwplfr dvsfyildli mlilffldsl iawwesllll layafyvftm
      601 kwnkhievwv keqlsrrpva kvmaledlsk pgdgaiavde lqdnkklklp slltrgssst
      661 slhnstirst iyqlmlhsld plrevrlake keeeslnqga raqpqakaes kpeeeepakl
      721 pavtvtpapv pdikgdqken pggqedvaea estgempgee getagegete eksggetqpe
      781 gegetetqgk geecedenea egkgdneged egeihaedge mkgnegetes qelsaenhge
      841 akndekgved gggsdggdse eeeeeeeeqe eeeeeeeqee eeeeeeeeee kgneeplsld
      901 wpetrqkqai ylfllpivfp lwltvpdvrr qesrkffvft flgsimwiam fsylmvwwah
      961 qvgetigise eimgltilaa gtsipdlits vivarkglgd mavsssvgsn ifditvgvwl
     1021 llprlvcngv isahhnlhlp gssnspasa
//
LOCUS       XP_047289284            1031 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium/potassium/calcium exchanger 1 isoform X6 [Homo sapiens].
ACCESSION   XP_047289284
VERSION     XP_047289284.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433328.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1031
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1031
                     /product="sodium/potassium/calcium exchanger 1 isoform X6"
                     /calculated_mol_wt=113458
     Region          1..1004
                     /region_name="2A1904"
                     /note="K+-dependent Na+/Ca+ exchanger; TIGR00927"
                     /db_xref="CDD:273344"
     CDS             1..1031
                     /gene="SLC24A1"
                     /gene_synonym="CSNB1D; HsT17412; NCKX; NCKX1; RODX"
                     /coded_by="XM_047433328.1:262..3357"
                     /db_xref="GeneID:9187"
                     /db_xref="HGNC:HGNC:10975"
                     /db_xref="MIM:603617"
ORIGIN      
        1 mgklirmgpq erwllrtkrl hwsrllfllg mliigstyqh lrrprglssl waavsshqpi
       61 klasrdlsse emmmmsssps kpssemggkm lvpqasvgsd eatlsmtven ipsmpkrtak
      121 miptttknny sptaagterr kedtptssrt ltyytstssr qivkkytptp rgemksyspt
      181 qvrekvkytp sprgrrvgty vpstfmtmet shaitprttv kdsditatyk iletnslkri
      241 meettpttlk gmfdstptfl theveanvlt sprsvmeknn lfpprrvesn ssahpwglvg
      301 ksnpktpqgt vllhtpatse gqvtistmtg sspaetkaft aawslrnpsp rtsvsaikta
      361 paivwrlakk pstapststt ptvrakltmq vhhcvvvkpt pamlttpsps lttallpeel
      421 spspsvlpps lpdlhpkgey ppdlfsveer rqgwvvlhvf gmmyvfvala ivcdeyfvpa
      481 lgvitdklqi sedvagatfm aaggsapelf tsligvfish snvgigtivg savfnilfvi
      541 gtcslfsrei lnltwwplfr dvsfyildli mlilffldsl iawwesllll layafyvftm
      601 kwnkhievwv keqlsrrpva kvmaledlsk lpslltrgss stslhnstir stiyqlmlhs
      661 ldplrevrla kekeeeslnq garaqpqaka eskpeeeepa klpavtvtpa pvpdikgdqk
      721 enpggqedva eaestgempg eegetagege teeksggetq pegegetetq gkgeeceden
      781 eaegkgdneg edegeihaed gemkgneget esqelsaenh geakndekgv edgggsdggd
      841 seeeeeeeee qeeeeeeeeq eeeeeeeeee eekgneepls ldwpetrqkq aiylfllpiv
      901 fplwltvpdv rrqesrkffv ftflgsimwi amfsylmvww ahqvgetigi seeimgltil
      961 aagtsipdli tsvivarkgl gdmavsssvg snifditvgv wlllprlvcn gvisahhnlh
     1021 lpgssnspas a
//
LOCUS       XP_047289286            1030 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium/potassium/calcium exchanger 1 isoform X7 [Homo sapiens].
ACCESSION   XP_047289286
VERSION     XP_047289286.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433330.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1030
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1030
                     /product="sodium/potassium/calcium exchanger 1 isoform X7"
                     /calculated_mol_wt=113406
     Region          1..1018
                     /region_name="2A1904"
                     /note="K+-dependent Na+/Ca+ exchanger; TIGR00927"
                     /db_xref="CDD:273344"
     CDS             1..1030
                     /gene="SLC24A1"
                     /gene_synonym="CSNB1D; HsT17412; NCKX; NCKX1; RODX"
                     /coded_by="XM_047433330.1:262..3354"
                     /db_xref="GeneID:9187"
                     /db_xref="HGNC:HGNC:10975"
                     /db_xref="MIM:603617"
ORIGIN      
        1 mgklirmgpq erwllrtkrl hwsrllfllg mliigstyqh lrrprglssl waavsshqpi
       61 klasrdlsse emmmmsssps kpssemggkm lvpqasvgsd eatlsmtven ipsmpkrtak
      121 miptttknny sptaagterr kedtptssrt ltyytstssr qivkkytptp rgemksyspt
      181 qvrekvkytp sprgrrvgty vpstfmtmet shaitprttv kdsditatyk iletnslkri
      241 meettpttlk gmfdstptfl theveanvlt sprsvmeknn lfpprrvesn ssahpwglvg
      301 ksnpktpqgt vllhtpatse gqvtistmtg sspaetkaft aawslrnpsp rtsvsaikta
      361 paivwrlakk pstapststt ptvrakltmq vhhcvvvkpt pamlttpsps lttallpeel
      421 spspsvlpps lpdlhpkgey ppdlfsveer rqgwvvlhvf gmmyvfvala ivcdeyfvpa
      481 lgvitdklqi sedvagatfm aaggsapelf tsligvfish snvgigtivg savfnilfvi
      541 gtcslfsrei lnltwwplfr dvsfyildli mlilffldsl iawwesllll layafyvftm
      601 kwnkhievwv keqlsrrpva kvmaledlsk pgdgaiavde lqdnkklklp slltrgssst
      661 slhnstirst iyqlmlhsld plrevrlake keeeslnqga raqpqakaes kpeeeepakl
      721 pavtvtpapv pdikgdqken pggqedvaea estgempgee getagegete eksggetqpe
      781 gegetetqgk geecedenea egkgdneged egeihaedge mkgnegetes qelsaenhge
      841 akndekgved gggsdggdse eeeeeeeeqe eeeeeeeqee eeeeeeeeee kgneeplsld
      901 wpetrqkqai ylfllpivfp lwltvpdvrr qesrkffvft flgsimwiam fsylmvwwah
      961 qvgetigise eimgltilaa gtsipdlits vivarkglgd mavsssvgsn ifditvgvgs
     1021 cemfqhgaih
//
LOCUS       XP_011520524            1030 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium/potassium/calcium exchanger 1 isoform X7 [Homo sapiens].
ACCESSION   XP_011520524
VERSION     XP_011520524.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522222.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1030
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1030
                     /product="sodium/potassium/calcium exchanger 1 isoform X7"
                     /calculated_mol_wt=113406
     Region          1..1018
                     /region_name="2A1904"
                     /note="K+-dependent Na+/Ca+ exchanger; TIGR00927"
                     /db_xref="CDD:273344"
     CDS             1..1030
                     /gene="SLC24A1"
                     /gene_synonym="CSNB1D; HsT17412; NCKX; NCKX1; RODX"
                     /coded_by="XM_011522222.4:262..3354"
                     /db_xref="GeneID:9187"
                     /db_xref="HGNC:HGNC:10975"
                     /db_xref="MIM:603617"
ORIGIN      
        1 mgklirmgpq erwllrtkrl hwsrllfllg mliigstyqh lrrprglssl waavsshqpi
       61 klasrdlsse emmmmsssps kpssemggkm lvpqasvgsd eatlsmtven ipsmpkrtak
      121 miptttknny sptaagterr kedtptssrt ltyytstssr qivkkytptp rgemksyspt
      181 qvrekvkytp sprgrrvgty vpstfmtmet shaitprttv kdsditatyk iletnslkri
      241 meettpttlk gmfdstptfl theveanvlt sprsvmeknn lfpprrvesn ssahpwglvg
      301 ksnpktpqgt vllhtpatse gqvtistmtg sspaetkaft aawslrnpsp rtsvsaikta
      361 paivwrlakk pstapststt ptvrakltmq vhhcvvvkpt pamlttpsps lttallpeel
      421 spspsvlpps lpdlhpkgey ppdlfsveer rqgwvvlhvf gmmyvfvala ivcdeyfvpa
      481 lgvitdklqi sedvagatfm aaggsapelf tsligvfish snvgigtivg savfnilfvi
      541 gtcslfsrei lnltwwplfr dvsfyildli mlilffldsl iawwesllll layafyvftm
      601 kwnkhievwv keqlsrrpva kvmaledlsk pgdgaiavde lqdnkklklp slltrgssst
      661 slhnstirst iyqlmlhsld plrevrlake keeeslnqga raqpqakaes kpeeeepakl
      721 pavtvtpapv pdikgdqken pggqedvaea estgempgee getagegete eksggetqpe
      781 gegetetqgk geecedenea egkgdneged egeihaedge mkgnegetes qelsaenhge
      841 akndekgved gggsdggdse eeeeeeeeqe eeeeeeeqee eeeeeeeeee kgneeplsld
      901 wpetrqkqai ylfllpivfp lwltvpdvrr qesrkffvft flgsimwiam fsylmvwwah
      961 qvgetigise eimgltilaa gtsipdlits vivarkglgd mavsssvgsn ifditvgvgs
     1021 cemfqhgaih
//
LOCUS       XP_047289287            1019 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium/potassium/calcium exchanger 1 isoform X8 [Homo sapiens].
ACCESSION   XP_047289287
VERSION     XP_047289287.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433331.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1019
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1019
                     /product="sodium/potassium/calcium exchanger 1 isoform X8"
                     /calculated_mol_wt=111608
     Region          1..992
                     /region_name="2A1904"
                     /note="K+-dependent Na+/Ca+ exchanger; TIGR00927"
                     /db_xref="CDD:273344"
     CDS             1..1019
                     /gene="SLC24A1"
                     /gene_synonym="CSNB1D; HsT17412; NCKX; NCKX1; RODX"
                     /coded_by="XM_047433331.1:262..3321"
                     /db_xref="GeneID:9187"
                     /db_xref="HGNC:HGNC:10975"
                     /db_xref="MIM:603617"
ORIGIN      
        1 mgklirmgpq erwllrtkrl hwsrllfllg mliigstyqh lrrprglssl waavsshqpi
       61 klasrdlsse emmmmsssps kpssemggkm lvpqasvgsd eatlsmtven ipsmpkrtak
      121 miptttknny sptaagterr kedtptssrt ltyytstssr qivkkytptp rgemksyspt
      181 qvrekvkytp sprgrrvgty vpstfmtmet shaitprttv kdsditatyk iletnslkri
      241 meettpttlk gmfdstptfl theveanvlt sprsvmeknn lfpprrvesn ssahpwglvg
      301 ksnpktpqgt vllhtpatse gqvtistmtg sspaetkaft aawslrnpsp rtsvsaikta
      361 paivwrlakk pstapststt ptvrakltmq vhhcvvvkpt pamlttpsps lttallpeel
      421 spspsvlpps lpdlhpkgey ppdlfsveer rqgwvvlhvf gmmyvfvala ivcdeyfvpa
      481 lgvitdklqi sedvagatfm aaggsapelf tsligvfish snvgigtivg savfnilfvi
      541 gtcslfsrei lnltwwplfr dvsfyildli mlilffldsl iawwesllll layafyvftm
      601 kwnkhievwv keqlsrrpva kvmaledlsk pgdgaiavde lqdnkklklp slltrgssst
      661 slhnstirst iyqlmlhsld plrevrlake keeeslnqga raqpqakaes kpeeeepakl
      721 pavtvtpapv pdikgdqken pggqedvaea estgempgee getagegete eksggetqpe
      781 gegetetqgk geecedenea egkgdneged egeihaedge mkgnegetes qelsaenhge
      841 akndekgved gggsdggdse eeeeeeeeqe eeeeeeeqee eeeeeeeeee kgneeplsld
      901 wpetrqkqai ylfllpivfp lwltvpdvrr qvgetigise eimgltilaa gtsipdlits
      961 vivarkglgd mavsssvgsn ifditvgvwl llprlvcngv isahhnlhlp gssnspasa
//
LOCUS       XP_047289288            1001 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium/potassium/calcium exchanger 1 isoform X9 [Homo sapiens].
ACCESSION   XP_047289288
VERSION     XP_047289288.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433332.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1001
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1001
                     /product="sodium/potassium/calcium exchanger 1 isoform X9"
                     /calculated_mol_wt=109715
     Region          1..974
                     /region_name="2A1904"
                     /note="K+-dependent Na+/Ca+ exchanger; TIGR00927"
                     /db_xref="CDD:273344"
     CDS             1..1001
                     /gene="SLC24A1"
                     /gene_synonym="CSNB1D; HsT17412; NCKX; NCKX1; RODX"
                     /coded_by="XM_047433332.1:262..3267"
                     /db_xref="GeneID:9187"
                     /db_xref="HGNC:HGNC:10975"
                     /db_xref="MIM:603617"
ORIGIN      
        1 mgklirmgpq erwllrtkrl hwsrllfllg mliigstyqh lrrprglssl waavsshqpi
       61 klasrdlsse emmmmsssps kpssemggkm lvpqasvgsd eatlsmtven ipsmpkrtak
      121 miptttknny sptaagterr kedtptssrt ltyytstssr qivkkytptp rgemksyspt
      181 qvrekvkytp sprgrrvgty vpstfmtmet shaitprttv kdsditatyk iletnslkri
      241 meettpttlk gmfdstptfl theveanvlt sprsvmeknn lfpprrvesn ssahpwglvg
      301 ksnpktpqgt vllhtpatse gqvtistmtg sspaetkaft aawslrnpsp rtsvsaikta
      361 paivwrlakk pstapststt ptvrakltmq vhhcvvvkpt pamlttpsps lttallpeel
      421 spspsvlpps lpdlhpkgey ppdlfsveer rqgwvvlhvf gmmyvfvala ivcdeyfvpa
      481 lgvitdklqi sedvagatfm aaggsapelf tsligvfish snvgigtivg savfnilfvi
      541 gtcslfsrei lnltwwplfr dvsfyildli mlilffldsl iawwesllll layafyvftm
      601 kwnkhievwv keqlsrrpva kvmaledlsk lpslltrgss stslhnstir stiyqlmlhs
      661 ldplrevrla kekeeeslnq garaqpqaka eskpeeeepa klpavtvtpa pvpdikgdqk
      721 enpggqedva eaestgempg eegetagege teeksggetq pegegetetq gkgeeceden
      781 eaegkgdneg edegeihaed gemkgneget esqelsaenh geakndekgv edgggsdggd
      841 seeeeeeeee qeeeeeeeeq eeeeeeeeee eekgneepls ldwpetrqkq aiylfllpiv
      901 fplwltvpdv rrqvgetigi seeimgltil aagtsipdli tsvivarkgl gdmavsssvg
      961 snifditvgv wlllprlvcn gvisahhnlh lpgssnspas a
//
LOCUS       XP_047289289            1000 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium/potassium/calcium exchanger 1 isoform X10 [Homo sapiens].
ACCESSION   XP_047289289
VERSION     XP_047289289.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433333.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1000
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..1000
                     /product="sodium/potassium/calcium exchanger 1 isoform
                     X10"
                     /calculated_mol_wt=109663
     Region          1..988
                     /region_name="2A1904"
                     /note="K+-dependent Na+/Ca+ exchanger; TIGR00927"
                     /db_xref="CDD:273344"
     CDS             1..1000
                     /gene="SLC24A1"
                     /gene_synonym="CSNB1D; HsT17412; NCKX; NCKX1; RODX"
                     /coded_by="XM_047433333.1:262..3264"
                     /db_xref="GeneID:9187"
                     /db_xref="HGNC:HGNC:10975"
                     /db_xref="MIM:603617"
ORIGIN      
        1 mgklirmgpq erwllrtkrl hwsrllfllg mliigstyqh lrrprglssl waavsshqpi
       61 klasrdlsse emmmmsssps kpssemggkm lvpqasvgsd eatlsmtven ipsmpkrtak
      121 miptttknny sptaagterr kedtptssrt ltyytstssr qivkkytptp rgemksyspt
      181 qvrekvkytp sprgrrvgty vpstfmtmet shaitprttv kdsditatyk iletnslkri
      241 meettpttlk gmfdstptfl theveanvlt sprsvmeknn lfpprrvesn ssahpwglvg
      301 ksnpktpqgt vllhtpatse gqvtistmtg sspaetkaft aawslrnpsp rtsvsaikta
      361 paivwrlakk pstapststt ptvrakltmq vhhcvvvkpt pamlttpsps lttallpeel
      421 spspsvlpps lpdlhpkgey ppdlfsveer rqgwvvlhvf gmmyvfvala ivcdeyfvpa
      481 lgvitdklqi sedvagatfm aaggsapelf tsligvfish snvgigtivg savfnilfvi
      541 gtcslfsrei lnltwwplfr dvsfyildli mlilffldsl iawwesllll layafyvftm
      601 kwnkhievwv keqlsrrpva kvmaledlsk pgdgaiavde lqdnkklklp slltrgssst
      661 slhnstirst iyqlmlhsld plrevrlake keeeslnqga raqpqakaes kpeeeepakl
      721 pavtvtpapv pdikgdqken pggqedvaea estgempgee getagegete eksggetqpe
      781 gegetetqgk geecedenea egkgdneged egeihaedge mkgnegetes qelsaenhge
      841 akndekgved gggsdggdse eeeeeeeeqe eeeeeeeqee eeeeeeeeee kgneeplsld
      901 wpetrqkqai ylfllpivfp lwltvpdvrr qvgetigise eimgltilaa gtsipdlits
      961 vivarkglgd mavsssvgsn ifditvgvgs cemfqhgaih
//
LOCUS       XP_047289290             982 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium/potassium/calcium exchanger 1 isoform X11 [Homo sapiens].
ACCESSION   XP_047289290
VERSION     XP_047289290.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433334.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..982
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..982
                     /product="sodium/potassium/calcium exchanger 1 isoform
                     X11"
                     /calculated_mol_wt=107770
     Region          1..970
                     /region_name="2A1904"
                     /note="K+-dependent Na+/Ca+ exchanger; TIGR00927"
                     /db_xref="CDD:273344"
     CDS             1..982
                     /gene="SLC24A1"
                     /gene_synonym="CSNB1D; HsT17412; NCKX; NCKX1; RODX"
                     /coded_by="XM_047433334.1:262..3210"
                     /db_xref="GeneID:9187"
                     /db_xref="HGNC:HGNC:10975"
                     /db_xref="MIM:603617"
ORIGIN      
        1 mgklirmgpq erwllrtkrl hwsrllfllg mliigstyqh lrrprglssl waavsshqpi
       61 klasrdlsse emmmmsssps kpssemggkm lvpqasvgsd eatlsmtven ipsmpkrtak
      121 miptttknny sptaagterr kedtptssrt ltyytstssr qivkkytptp rgemksyspt
      181 qvrekvkytp sprgrrvgty vpstfmtmet shaitprttv kdsditatyk iletnslkri
      241 meettpttlk gmfdstptfl theveanvlt sprsvmeknn lfpprrvesn ssahpwglvg
      301 ksnpktpqgt vllhtpatse gqvtistmtg sspaetkaft aawslrnpsp rtsvsaikta
      361 paivwrlakk pstapststt ptvrakltmq vhhcvvvkpt pamlttpsps lttallpeel
      421 spspsvlpps lpdlhpkgey ppdlfsveer rqgwvvlhvf gmmyvfvala ivcdeyfvpa
      481 lgvitdklqi sedvagatfm aaggsapelf tsligvfish snvgigtivg savfnilfvi
      541 gtcslfsrei lnltwwplfr dvsfyildli mlilffldsl iawwesllll layafyvftm
      601 kwnkhievwv keqlsrrpva kvmaledlsk lpslltrgss stslhnstir stiyqlmlhs
      661 ldplrevrla kekeeeslnq garaqpqaka eskpeeeepa klpavtvtpa pvpdikgdqk
      721 enpggqedva eaestgempg eegetagege teeksggetq pegegetetq gkgeeceden
      781 eaegkgdneg edegeihaed gemkgneget esqelsaenh geakndekgv edgggsdggd
      841 seeeeeeeee qeeeeeeeeq eeeeeeeeee eekgneepls ldwpetrqkq aiylfllpiv
      901 fplwltvpdv rrqvgetigi seeimgltil aagtsipdli tsvivarkgl gdmavsssvg
      961 snifditvgv gscemfqhga ih
//
LOCUS       XP_016878214             966 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium/potassium/calcium exchanger 1 isoform X12 [Homo sapiens].
ACCESSION   XP_016878214
VERSION     XP_016878214.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022725.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..966
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..966
                     /product="sodium/potassium/calcium exchanger 1 isoform
                     X12"
                     /calculated_mol_wt=106503
     Region          1..931
                     /region_name="2A1904"
                     /note="K+-dependent Na+/Ca+ exchanger; TIGR00927"
                     /db_xref="CDD:273344"
     CDS             1..966
                     /gene="SLC24A1"
                     /gene_synonym="CSNB1D; HsT17412; NCKX; NCKX1; RODX"
                     /coded_by="XM_017022725.3:262..3162"
                     /db_xref="GeneID:9187"
                     /db_xref="HGNC:HGNC:10975"
                     /db_xref="MIM:603617"
ORIGIN      
        1 mgklirmgpq erwllrtkrl hwsrllfllg mliigstyqh lrrprglssl waavsshqpi
       61 klasrdlsse emmmmsssps kpssemggkm lvpqasvgsd eatlsmtven ipsmpkrtak
      121 miptttknny sptaagterr kedtptssrt ltyytstssr qivkkytptp rgemksyspt
      181 qvrekvkytp sprgrrvgty vpstfmtmet shaitprttv kdsditatyk iletnslkri
      241 meettpttlk gmfdstptfl theveanvlt sprsvmeknn lfpprrvesn ssahpwglvg
      301 ksnpktpqgt vllhtpatse gqvtistmtg sspaetkaft aawslrnpsp rtsvsaikta
      361 paivwrlakk pstapststt ptvrakltmq vhhcvvvkpt pamlttpsps lttallpeel
      421 spspsvlpps lpdlhpkgey ppdlfsveer rqgwvvlhvf gmmyvfvala ivcdeyfvpa
      481 lgvitdklqi sedvagatfm aaggsapelf tsligvfish snvgigtivg savfnilfvi
      541 gtcslfsrei lnltwwplfr dvsfyildli mlilffldsl iawwesllll layafyvftm
      601 kwnkhievwv keqlsrrpva kvmaledlsk pgdgaiavde lqdnkklklp slltrgssst
      661 slhnstirst iyqlmlhsld plrevrlake keeeslnqga raqpqakaes kpeeeepakl
      721 pavtvtpapv pdikgdqken pggqedvaea estgempgee getagegete eksggetqpe
      781 gegetetqgk geecedenea egkgdneged egeihaedge mkgnegetes qelsaenhge
      841 akndekgved gggsdggdse eeeeeeeeqe eeeeeeeqee eeeeeeeeee kgneeplsld
      901 wpetrqkqai ylfllpivfp lwltvpdvrr qslalvaqag vqwrdlgtpq pspprfkqfs
      961 clslks
//
LOCUS       XP_047289291             955 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium/potassium/calcium exchanger 1 isoform X13 [Homo sapiens].
ACCESSION   XP_047289291
VERSION     XP_047289291.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433335.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..955
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..955
                     /product="sodium/potassium/calcium exchanger 1 isoform
                     X13"
                     /calculated_mol_wt=105201
     Region          1..955
                     /region_name="2A1904"
                     /note="K+-dependent Na+/Ca+ exchanger; TIGR00927"
                     /db_xref="CDD:273344"
     CDS             1..955
                     /gene="SLC24A1"
                     /gene_synonym="CSNB1D; HsT17412; NCKX; NCKX1; RODX"
                     /coded_by="XM_047433335.1:262..3129"
                     /db_xref="GeneID:9187"
                     /db_xref="HGNC:HGNC:10975"
                     /db_xref="MIM:603617"
ORIGIN      
        1 mgklirmgpq erwllrtkrl hwsrllfllg mliigstyqh lrrprglssl waavsshqpi
       61 klasrdlsse emmmmsssps kpssemggkm lvpqasvgsd eatlsmtven ipsmpkrtak
      121 miptttknny sptaagterr kedtptssrt ltyytstssr qivkkytptp rgemksyspt
      181 qvrekvkytp sprgrrvgty vpstfmtmet shaitprttv kdsditatyk iletnslkri
      241 meettpttlk gmfdstptfl theveanvlt sprsvmeknn lfpprrvesn ssahpwglvg
      301 ksnpktpqgt vllhtpatse gqvtistmtg sspaetkaft aawslrnpsp rtsvsaikta
      361 paivwrlakk pstapststt ptvrakltmq vhhcvvvkpt pamlttpsps lttallpeel
      421 spspsvlpps lpdlhpkgey ppdlfsveer rqgwvvlhvf gmmyvfvala ivcdeyfvpa
      481 lgvitdklqi sedvagatfm aaggsapelf tsligvfish snvgigtivg savfnilfvi
      541 gtcslfsrei lnltwwplfr dvsfyildli mlilffldsl iawwesllll layafyvftm
      601 kwnkhievwv keqlsrrpva kvmaledlsk edvaeaestg empgeegeta gegeteeksg
      661 getqpegege tetqgkgeec edeneaegkg dnegedegei haedgemkgn egetesqels
      721 aenhgeaknd ekgvedgggs dggdseeeee eeeeqeeeee eeeqeeeeee eeeeeekgne
      781 eplsldwpet rqkqaiylfl lpivfplwlt vpdvrrqvge tigiseeimg ltilaagtsi
      841 pdlitsviva rkglgdmavs ssvgsnifdi tvglpvpwll fslinglqpv pvssnglfca
      901 ivllflmllf vissiasckw rmnkilgftm fllyfvflii svmledriis cpvsv
//
LOCUS       XP_047289292             948 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium/potassium/calcium exchanger 1 isoform X14 [Homo sapiens].
ACCESSION   XP_047289292
VERSION     XP_047289292.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433336.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..948
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..948
                     /product="sodium/potassium/calcium exchanger 1 isoform
                     X14"
                     /calculated_mol_wt=104609
     Region          1..913
                     /region_name="2A1904"
                     /note="K+-dependent Na+/Ca+ exchanger; TIGR00927"
                     /db_xref="CDD:273344"
     CDS             1..948
                     /gene="SLC24A1"
                     /gene_synonym="CSNB1D; HsT17412; NCKX; NCKX1; RODX"
                     /coded_by="XM_047433336.1:262..3108"
                     /db_xref="GeneID:9187"
                     /db_xref="HGNC:HGNC:10975"
                     /db_xref="MIM:603617"
ORIGIN      
        1 mgklirmgpq erwllrtkrl hwsrllfllg mliigstyqh lrrprglssl waavsshqpi
       61 klasrdlsse emmmmsssps kpssemggkm lvpqasvgsd eatlsmtven ipsmpkrtak
      121 miptttknny sptaagterr kedtptssrt ltyytstssr qivkkytptp rgemksyspt
      181 qvrekvkytp sprgrrvgty vpstfmtmet shaitprttv kdsditatyk iletnslkri
      241 meettpttlk gmfdstptfl theveanvlt sprsvmeknn lfpprrvesn ssahpwglvg
      301 ksnpktpqgt vllhtpatse gqvtistmtg sspaetkaft aawslrnpsp rtsvsaikta
      361 paivwrlakk pstapststt ptvrakltmq vhhcvvvkpt pamlttpsps lttallpeel
      421 spspsvlpps lpdlhpkgey ppdlfsveer rqgwvvlhvf gmmyvfvala ivcdeyfvpa
      481 lgvitdklqi sedvagatfm aaggsapelf tsligvfish snvgigtivg savfnilfvi
      541 gtcslfsrei lnltwwplfr dvsfyildli mlilffldsl iawwesllll layafyvftm
      601 kwnkhievwv keqlsrrpva kvmaledlsk lpslltrgss stslhnstir stiyqlmlhs
      661 ldplrevrla kekeeeslnq garaqpqaka eskpeeeepa klpavtvtpa pvpdikgdqk
      721 enpggqedva eaestgempg eegetagege teeksggetq pegegetetq gkgeeceden
      781 eaegkgdneg edegeihaed gemkgneget esqelsaenh geakndekgv edgggsdggd
      841 seeeeeeeee qeeeeeeeeq eeeeeeeeee eekgneepls ldwpetrqkq aiylfllpiv
      901 fplwltvpdv rrqslalvaq agvqwrdlgt pqpspprfkq fsclslks
//
LOCUS       XP_047289294             886 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium/potassium/calcium exchanger 1 isoform X15 [Homo sapiens].
ACCESSION   XP_047289294
VERSION     XP_047289294.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433338.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..886
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..886
                     /product="sodium/potassium/calcium exchanger 1 isoform
                     X15"
                     /calculated_mol_wt=97363
     Region          1..874
                     /region_name="2A1904"
                     /note="K+-dependent Na+/Ca+ exchanger; TIGR00927"
                     /db_xref="CDD:273344"
     CDS             1..886
                     /gene="SLC24A1"
                     /gene_synonym="CSNB1D; HsT17412; NCKX; NCKX1; RODX"
                     /coded_by="XM_047433338.1:262..2922"
                     /db_xref="GeneID:9187"
                     /db_xref="HGNC:HGNC:10975"
                     /db_xref="MIM:603617"
ORIGIN      
        1 mgklirmgpq erwllrtkrl hwsrllfllg mliigstyqh lrrprglssl waavsshqpi
       61 klasrdlsse emmmmsssps kpssemggkm lvpqasvgsd eatlsmtven ipsmpkrtak
      121 miptttknny sptaagterr kedtptssrt ltyytstssr qivkkytptp rgemksyspt
      181 qvrekvkytp sprgrrvgty vpstfmtmet shaitprttv kdsditatyk iletnslkri
      241 meettpttlk gmfdstptfl theveanvlt sprsvmeknn lfpprrvesn ssahpwglvg
      301 ksnpktpqgt vllhtpatse gqvtistmtg sspaetkaft aawslrnpsp rtsvsaikta
      361 paivwrlakk pstapststt ptvrakltmq vhhcvvvkpt pamlttpsps lttallpeel
      421 spspsvlpps lpdlhpkgey ppdlfsveer rqgwvvlhvf gmmyvfvala ivcdeyfvpa
      481 lgvitdklqi sedvagatfm aaggsapelf tsligvfish snvgigtivg savfnilfvi
      541 gtcslfsrei lnltwwplfr dvsfyildli mlilffldsl iawwesllll layafyvftm
      601 kwnkhievwv keqlsrrpva kvmaledlsk edvaeaestg empgeegeta gegeteeksg
      661 getqpegege tetqgkgeec edeneaegkg dnegedegei haedgemkgn egetesqels
      721 aenhgeaknd ekgvedgggs dggdseeeee eeeeqeeeee eeeqeeeeee eeeeeekgne
      781 eplsldwpet rqkqaiylfl lpivfplwlt vpdvrrqvge tigiseeimg ltilaagtsi
      841 pdlitsviva rkglgdmavs ssvgsnifdi tvgvgscemf qhgaih
//
LOCUS       XP_005254838             717 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium/potassium/calcium exchanger 1 isoform X16 [Homo sapiens].
ACCESSION   XP_005254838
VERSION     XP_005254838.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254781.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..717
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..717
                     /product="sodium/potassium/calcium exchanger 1 isoform
                     X16"
                     /calculated_mol_wt=79174
     Region          1..>637
                     /region_name="2A1904"
                     /note="K+-dependent Na+/Ca+ exchanger; TIGR00927"
                     /db_xref="CDD:273344"
     CDS             1..717
                     /gene="SLC24A1"
                     /gene_synonym="CSNB1D; HsT17412; NCKX; NCKX1; RODX"
                     /coded_by="XM_005254781.5:262..2415"
                     /db_xref="GeneID:9187"
                     /db_xref="HGNC:HGNC:10975"
                     /db_xref="MIM:603617"
ORIGIN      
        1 mgklirmgpq erwllrtkrl hwsrllfllg mliigstyqh lrrprglssl waavsshqpi
       61 klasrdlsse emmmmsssps kpssemggkm lvpqasvgsd eatlsmtven ipsmpkrtak
      121 miptttknny sptaagterr kedtptssrt ltyytstssr qivkkytptp rgemksyspt
      181 qvrekvkytp sprgrrvgty vpstfmtmet shaitprttv kdsditatyk iletnslkri
      241 meettpttlk gmfdstptfl theveanvlt sprsvmeknn lfpprrvesn ssahpwglvg
      301 ksnpktpqgt vllhtpatse gqvtistmtg sspaetkaft aawslrnpsp rtsvsaikta
      361 paivwrlakk pstapststt ptvrakltmq vhhcvvvkpt pamlttpsps lttallpeel
      421 spspsvlpps lpdlhpkgey ppdlfsveer rqgwvvlhvf gmmyvfvala ivcdeyfvpa
      481 lgvitdklqi sedvagatfm aaggsapelf tsligvfish snvgigtivg savfnilfvi
      541 gtcslfsrei lnltwwplfr dvsfyildli mlilffldsl iawwesllll layafyvftm
      601 kwnkhievwv keqlsrrpva kvmaledlsk pgdgaiavde lqdnkklklp slltrgssst
      661 slhnstirst iyqlmlhsld plrevrlake keeeslnqga raqpqakaes kpegrcg
//
LOCUS       XP_011520528             688 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium/potassium/calcium exchanger 1 isoform X17 [Homo sapiens].
ACCESSION   XP_011520528
VERSION     XP_011520528.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522226.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..688
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..688
                     /product="sodium/potassium/calcium exchanger 1 isoform
                     X17"
                     /calculated_mol_wt=75969
     Region          1..>637
                     /region_name="2A1904"
                     /note="K+-dependent Na+/Ca+ exchanger; TIGR00927"
                     /db_xref="CDD:273344"
     CDS             1..688
                     /gene="SLC24A1"
                     /gene_synonym="CSNB1D; HsT17412; NCKX; NCKX1; RODX"
                     /coded_by="XM_011522226.4:262..2328"
                     /db_xref="GeneID:9187"
                     /db_xref="HGNC:HGNC:10975"
                     /db_xref="MIM:603617"
ORIGIN      
        1 mgklirmgpq erwllrtkrl hwsrllfllg mliigstyqh lrrprglssl waavsshqpi
       61 klasrdlsse emmmmsssps kpssemggkm lvpqasvgsd eatlsmtven ipsmpkrtak
      121 miptttknny sptaagterr kedtptssrt ltyytstssr qivkkytptp rgemksyspt
      181 qvrekvkytp sprgrrvgty vpstfmtmet shaitprttv kdsditatyk iletnslkri
      241 meettpttlk gmfdstptfl theveanvlt sprsvmeknn lfpprrvesn ssahpwglvg
      301 ksnpktpqgt vllhtpatse gqvtistmtg sspaetkaft aawslrnpsp rtsvsaikta
      361 paivwrlakk pstapststt ptvrakltmq vhhcvvvkpt pamlttpsps lttallpeel
      421 spspsvlpps lpdlhpkgey ppdlfsveer rqgwvvlhvf gmmyvfvala ivcdeyfvpa
      481 lgvitdklqi sedvagatfm aaggsapelf tsligvfish snvgigtivg savfnilfvi
      541 gtcslfsrei lnltwwplfr dvsfyildli mlilffldsl iawwesllll layafyvftm
      601 kwnkhievwv keqlsrrpva kvmaledlsk pgdgaiavde lqdnkklklp slltrgssst
      661 slhnstirst iyqlmlhsld plregrcg
//
LOCUS       XP_047289295             670 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium/potassium/calcium exchanger 1 isoform X18 [Homo sapiens].
ACCESSION   XP_047289295
VERSION     XP_047289295.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433339.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..670
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..670
                     /product="sodium/potassium/calcium exchanger 1 isoform
                     X18"
                     /calculated_mol_wt=74076
     Region          1..>630
                     /region_name="2A1904"
                     /note="K+-dependent Na+/Ca+ exchanger; TIGR00927"
                     /db_xref="CDD:273344"
     CDS             1..670
                     /gene="SLC24A1"
                     /gene_synonym="CSNB1D; HsT17412; NCKX; NCKX1; RODX"
                     /coded_by="XM_047433339.1:262..2274"
                     /db_xref="GeneID:9187"
                     /db_xref="HGNC:HGNC:10975"
                     /db_xref="MIM:603617"
ORIGIN      
        1 mgklirmgpq erwllrtkrl hwsrllfllg mliigstyqh lrrprglssl waavsshqpi
       61 klasrdlsse emmmmsssps kpssemggkm lvpqasvgsd eatlsmtven ipsmpkrtak
      121 miptttknny sptaagterr kedtptssrt ltyytstssr qivkkytptp rgemksyspt
      181 qvrekvkytp sprgrrvgty vpstfmtmet shaitprttv kdsditatyk iletnslkri
      241 meettpttlk gmfdstptfl theveanvlt sprsvmeknn lfpprrvesn ssahpwglvg
      301 ksnpktpqgt vllhtpatse gqvtistmtg sspaetkaft aawslrnpsp rtsvsaikta
      361 paivwrlakk pstapststt ptvrakltmq vhhcvvvkpt pamlttpsps lttallpeel
      421 spspsvlpps lpdlhpkgey ppdlfsveer rqgwvvlhvf gmmyvfvala ivcdeyfvpa
      481 lgvitdklqi sedvagatfm aaggsapelf tsligvfish snvgigtivg savfnilfvi
      541 gtcslfsrei lnltwwplfr dvsfyildli mlilffldsl iawwesllll layafyvftm
      601 kwnkhievwv keqlsrrpva kvmaledlsk lpslltrgss stslhnstir stiyqlmlhs
      661 ldplregrcg
//
LOCUS       XP_047289302             324 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin-conjugating enzyme E2 Q2 isoform X1 [Homo sapiens].
ACCESSION   XP_047289302
VERSION     XP_047289302.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433346.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..324
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..324
                     /product="ubiquitin-conjugating enzyme E2 Q2 isoform X1"
                     /calculated_mol_wt=36706
     Region          156..311
                     /region_name="UBCc_UBE2Q"
                     /note="Ubiquitin-conjugating enzyme E2, catalytic (UBCc)
                     domain of ubiquitin-conjugating enzyme E2 Q1, Q2, and
                     related proteins; cd23802"
                     /db_xref="CDD:467422"
     CDS             1..324
                     /gene="UBE2Q2"
                     /coded_by="XM_047433346.1:311..1285"
                     /db_xref="GeneID:92912"
                     /db_xref="HGNC:HGNC:19248"
                     /db_xref="MIM:612501"
ORIGIN      
        1 mrmdslteek lecrlwccls dpsppglaar ccvlersivp slrqesypss spiwfvdsed
       61 pnltsvlerl edtknnnlng tteevtseee eeeeemaedi edldhyemke eepisgkkse
      121 degiekenla ilekirktqr qdhlngavsg svqasdrlmk elrdiyrsqs yktgiysvel
      181 indslydwhv klqkvdpdsp lhsdlqilke kegieyilln fsfkdnfpfd ppfvrvvlpv
      241 lsggyvlggg alcmelltkq gwssaysies vimqinatlv kgkarvqfga nknqynlara
      301 qqsynsivqi hekngwytpp kedg
//
LOCUS       XP_005254844             314 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin-conjugating enzyme E2 Q2 isoform X2 [Homo sapiens].
ACCESSION   XP_005254844
VERSION     XP_005254844.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254787.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..314
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..314
                     /product="ubiquitin-conjugating enzyme E2 Q2 isoform X2"
                     /calculated_mol_wt=35972
     Region          9..89
                     /region_name="RWD"
                     /note="RWD domain; cl02687"
                     /db_xref="CDD:413438"
     Region          207..>298
                     /region_name="UBCc_UBE2Q"
                     /note="Ubiquitin-conjugating enzyme E2, catalytic (UBCc)
                     domain of ubiquitin-conjugating enzyme E2 Q1, Q2, and
                     related proteins; cd23802"
                     /db_xref="CDD:467422"
     CDS             1..314
                     /gene="UBE2Q2"
                     /coded_by="XM_005254787.3:221..1165"
                     /db_xref="GeneID:92912"
                     /db_xref="HGNC:HGNC:19248"
                     /db_xref="MIM:612501"
ORIGIN      
        1 msvsglkael kflasifdkn herfrivswk ldelhcqflv pqqgsphslp ppltlhcnit
       61 esypssspiw fvdsedpnlt svlerledtk nnnllrqqlk wlicelcsly nlpkhldvem
      121 ldqplptgqn gtteevtsee eeeeeemaed iedldhyemk eeepisgkks edegiekenl
      181 ailekirktq rqdhlngavs gsvqasdrlm kelrdiyrsq syktgiysve lindslydwh
      241 vklqkvdpds plhsdlqilk ekegieyill nfsfkdnfpf dppfvrvvlp vlsgglvhps
      301 kgrwlnvltv vcld
//
LOCUS       XP_005254845             296 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin-conjugating enzyme E2 Q2 isoform X3 [Homo sapiens].
ACCESSION   XP_005254845
VERSION     XP_005254845.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254788.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..296
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..296
                     /product="ubiquitin-conjugating enzyme E2 Q2 isoform X3"
                     /calculated_mol_wt=33585
     Region          9..89
                     /region_name="RWD"
                     /note="RWD domain; cl02687"
                     /db_xref="CDD:413438"
     Region          <183..283
                     /region_name="UBCc_UBE2Q"
                     /note="Ubiquitin-conjugating enzyme E2, catalytic (UBCc)
                     domain of ubiquitin-conjugating enzyme E2 Q1, Q2, and
                     related proteins; cd23802"
                     /db_xref="CDD:467422"
     CDS             1..296
                     /gene="UBE2Q2"
                     /coded_by="XM_005254788.3:221..1111"
                     /db_xref="GeneID:92912"
                     /db_xref="HGNC:HGNC:19248"
                     /db_xref="MIM:612501"
ORIGIN      
        1 msvsglkael kflasifdkn herfrivswk ldelhcqflv pqqgsphslp ppltlhcnit
       61 esypssspiw fvdsedpnlt svlerledtk nnnllrqqlk wlicelcsly nlpkhldvem
      121 ldqplptgqn gtteevtsee eeeeeemaed iedldhyemk eeepisgkks edegiekenl
      181 ailekirktq rqdhlndnfp fdppfvrvvl pvlsggyvlg ggalcmellt kqgwssaysi
      241 esvimqinat lvkgkarvqf ganknqynla raqqsynsiv qihekngwyt ppkedg
//
LOCUS       XP_016878215             298 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin-conjugating enzyme E2 Q2 isoform X4 [Homo sapiens].
ACCESSION   XP_016878215
VERSION     XP_016878215.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022726.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..298
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..298
                     /product="ubiquitin-conjugating enzyme E2 Q2 isoform X4"
                     /calculated_mol_wt=34110
     Region          191..>282
                     /region_name="UBCc_UBE2Q"
                     /note="Ubiquitin-conjugating enzyme E2, catalytic (UBCc)
                     domain of ubiquitin-conjugating enzyme E2 Q1, Q2, and
                     related proteins; cd23802"
                     /db_xref="CDD:467422"
     CDS             1..298
                     /gene="UBE2Q2"
                     /coded_by="XM_017022726.2:311..1207"
                     /db_xref="GeneID:92912"
                     /db_xref="HGNC:HGNC:19248"
                     /db_xref="MIM:612501"
ORIGIN      
        1 mrmdslteek lecrlwccls dpsppglaar ccvlersivp slrqesypss spiwfvdsed
       61 pnltsvlerl edtknnnllr qqlkwlicel cslynlpkhl dvemldqplp tgqngtteev
      121 tseeeeeeee maediedldh yemkeeepis gkksedegie kenlaileki rktqrqdhln
      181 gavsgsvqas drlmkelrdi yrsqsyktgi ysvelindsl ydwhvklqkv dpdsplhsdl
      241 qilkekegie yillnfsfkd nfpfdppfvr vvlpvlsggl vhpskgrwln vltvvcld
//
LOCUS       XP_016878216             279 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin-conjugating enzyme E2 Q2 isoform X5 [Homo sapiens].
ACCESSION   XP_016878216
VERSION     XP_016878216.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022727.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..279
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..279
                     /product="ubiquitin-conjugating enzyme E2 Q2 isoform X5"
                     /calculated_mol_wt=31853
     Region          9..89
                     /region_name="RWD"
                     /note="RWD domain; cl02687"
                     /db_xref="CDD:413438"
     Region          172..>263
                     /region_name="UBCc_UBE2Q"
                     /note="Ubiquitin-conjugating enzyme E2, catalytic (UBCc)
                     domain of ubiquitin-conjugating enzyme E2 Q1, Q2, and
                     related proteins; cd23802"
                     /db_xref="CDD:467422"
     CDS             1..279
                     /gene="UBE2Q2"
                     /coded_by="XM_017022727.3:221..1060"
                     /db_xref="GeneID:92912"
                     /db_xref="HGNC:HGNC:19248"
                     /db_xref="MIM:612501"
ORIGIN      
        1 msvsglkael kflasifdkn herfrivswk ldelhcqflv pqqgsphslp ppltlhcnit
       61 esypssspiw fvdsedpnlt svlerledtk nnnlngttee vtseeeeeee emaediedld
      121 hyemkeeepi sgkksedegi ekenlailek irktqrqdhl ngavsgsvqa sdrlmkelrd
      181 iyrsqsyktg iysvelinds lydwhvklqk vdpdsplhsd lqilkekegi eyillnfsfk
      241 dnfpfdppfv rvvlpvlsgg lvhpskgrwl nvltvvcld
//
LOCUS       XP_047289303             280 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin-conjugating enzyme E2 Q2 isoform X6 [Homo sapiens].
ACCESSION   XP_047289303
VERSION     XP_047289303.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433347.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..280
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..280
                     /product="ubiquitin-conjugating enzyme E2 Q2 isoform X6"
                     /calculated_mol_wt=31723
     Region          <167..267
                     /region_name="UBCc_UBE2Q"
                     /note="Ubiquitin-conjugating enzyme E2, catalytic (UBCc)
                     domain of ubiquitin-conjugating enzyme E2 Q1, Q2, and
                     related proteins; cd23802"
                     /db_xref="CDD:467422"
     CDS             1..280
                     /gene="UBE2Q2"
                     /coded_by="XM_047433347.1:311..1153"
                     /db_xref="GeneID:92912"
                     /db_xref="HGNC:HGNC:19248"
                     /db_xref="MIM:612501"
ORIGIN      
        1 mrmdslteek lecrlwccls dpsppglaar ccvlersivp slrqesypss spiwfvdsed
       61 pnltsvlerl edtknnnllr qqlkwlicel cslynlpkhl dvemldqplp tgqngtteev
      121 tseeeeeeee maediedldh yemkeeepis gkksedegie kenlaileki rktqrqdhln
      181 dnfpfdppfv rvvlpvlsgg yvlgggalcm elltkqgwss aysiesvimq inatlvkgka
      241 rvqfganknq ynlaraqqsy nsivqihekn gwytppkedg
//
LOCUS       XP_016878217             261 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin-conjugating enzyme E2 Q2 isoform X7 [Homo sapiens].
ACCESSION   XP_016878217
VERSION     XP_016878217.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022728.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..261
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..261
                     /product="ubiquitin-conjugating enzyme E2 Q2 isoform X7"
                     /calculated_mol_wt=29466
     Region          9..89
                     /region_name="RWD"
                     /note="RWD domain; cl02687"
                     /db_xref="CDD:413438"
     Region          <148..248
                     /region_name="UBCc_UBE2Q"
                     /note="Ubiquitin-conjugating enzyme E2, catalytic (UBCc)
                     domain of ubiquitin-conjugating enzyme E2 Q1, Q2, and
                     related proteins; cd23802"
                     /db_xref="CDD:467422"
     CDS             1..261
                     /gene="UBE2Q2"
                     /coded_by="XM_017022728.3:221..1006"
                     /db_xref="GeneID:92912"
                     /db_xref="HGNC:HGNC:19248"
                     /db_xref="MIM:612501"
ORIGIN      
        1 msvsglkael kflasifdkn herfrivswk ldelhcqflv pqqgsphslp ppltlhcnit
       61 esypssspiw fvdsedpnlt svlerledtk nnnlngttee vtseeeeeee emaediedld
      121 hyemkeeepi sgkksedegi ekenlailek irktqrqdhl ndnfpfdppf vrvvlpvlsg
      181 gyvlgggalc melltkqgws saysiesvim qinatlvkgk arvqfgankn qynlaraqqs
      241 ynsivqihek ngwytppked g
//
LOCUS       XP_006720833             235 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin-conjugating enzyme E2 Q2 isoform X8 [Homo sapiens].
ACCESSION   XP_006720833
VERSION     XP_006720833.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720770.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..235
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..235
                     /product="ubiquitin-conjugating enzyme E2 Q2 isoform X8"
                     /calculated_mol_wt=26869
     Region          9..89
                     /region_name="RWD"
                     /note="RWD domain; cl02687"
                     /db_xref="CDD:413438"
     Region          <183..>219
                     /region_name="UBCc_UEV"
                     /note="Ubiquitin-conjugating enzyme E2, catalytic (UBCc)
                     domain/ubiquitin E2 variant (UEV) domain; cl49610"
                     /db_xref="CDD:483950"
     CDS             1..235
                     /gene="UBE2Q2"
                     /coded_by="XM_006720770.3:221..928"
                     /db_xref="GeneID:92912"
                     /db_xref="HGNC:HGNC:19248"
                     /db_xref="MIM:612501"
ORIGIN      
        1 msvsglkael kflasifdkn herfrivswk ldelhcqflv pqqgsphslp ppltlhcnit
       61 esypssspiw fvdsedpnlt svlerledtk nnnllrqqlk wlicelcsly nlpkhldvem
      121 ldqplptgqn gtteevtsee eeeeeemaed iedldhyemk eeepisgkks edegiekenl
      181 ailekirktq rqdhlndnfp fdppfvrvvl pvlsgglvhp skgrwlnvlt vvcld
//
LOCUS       XP_047289305             203 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin-conjugating enzyme E2 Q2 isoform X9 [Homo sapiens].
ACCESSION   XP_047289305
VERSION     XP_047289305.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433349.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..203
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..203
                     /product="ubiquitin-conjugating enzyme E2 Q2 isoform X9"
                     /calculated_mol_wt=23416
     Region          9..>69
                     /region_name="RWD"
                     /note="RWD domain; cl02687"
                     /db_xref="CDD:413438"
     CDS             1..203
                     /gene="UBE2Q2"
                     /coded_by="XM_047433349.1:221..832"
                     /db_xref="GeneID:92912"
                     /db_xref="HGNC:HGNC:19248"
                     /db_xref="MIM:612501"
ORIGIN      
        1 msvsglkael kflasifdkn herfrivswk ldelhcqflv pqqgsphslp ppltlhcnit
       61 esypssspiw fvdsedpnlt svlerledtk nnnllrqqlk wlicelcsly nlpkhldvem
      121 ldqplptgqn gtteevtsee eeeeeemaed iedldhyemk eeepisgkks edegiekenl
      181 ailekirktq rqdhlngfiq wns
//
LOCUS       XP_047289306             200 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin-conjugating enzyme E2 Q2 isoform X10 [Homo sapiens].
ACCESSION   XP_047289306
VERSION     XP_047289306.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433350.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..200
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..200
                     /product="ubiquitin-conjugating enzyme E2 Q2 isoform X10"
                     /calculated_mol_wt=22750
     Region          9..89
                     /region_name="RWD"
                     /note="RWD domain; cl02687"
                     /db_xref="CDD:413438"
     Region          <148..>184
                     /region_name="UBCc_UEV"
                     /note="Ubiquitin-conjugating enzyme E2, catalytic (UBCc)
                     domain/ubiquitin E2 variant (UEV) domain; cl49610"
                     /db_xref="CDD:483950"
     CDS             1..200
                     /gene="UBE2Q2"
                     /coded_by="XM_047433350.1:221..823"
                     /db_xref="GeneID:92912"
                     /db_xref="HGNC:HGNC:19248"
                     /db_xref="MIM:612501"
ORIGIN      
        1 msvsglkael kflasifdkn herfrivswk ldelhcqflv pqqgsphslp ppltlhcnit
       61 esypssspiw fvdsedpnlt svlerledtk nnnlngttee vtseeeeeee emaediedld
      121 hyemkeeepi sgkksedegi ekenlailek irktqrqdhl ndnfpfdppf vrvvlpvlsg
      181 glvhpskgrw lnvltvvcld
//
LOCUS       XP_011520530             198 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin-conjugating enzyme E2 Q2 isoform X11 [Homo sapiens].
ACCESSION   XP_011520530
VERSION     XP_011520530.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522228.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..198
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..198
                     /product="ubiquitin-conjugating enzyme E2 Q2 isoform X11"
                     /calculated_mol_wt=22834
     Region          9..>69
                     /region_name="RWD"
                     /note="RWD domain; cl02687"
                     /db_xref="CDD:413438"
     CDS             1..198
                     /gene="UBE2Q2"
                     /coded_by="XM_011522228.3:221..817"
                     /db_xref="GeneID:92912"
                     /db_xref="HGNC:HGNC:19248"
                     /db_xref="MIM:612501"
ORIGIN      
        1 msvsglkael kflasifdkn herfrivswk ldelhcqflv pqqgsphslp ppltlhcnit
       61 esypssspiw fvdsedpnlt svlerledtk nnnllrqqlk wlicelcsly nlpkhldvem
      121 ldqplptgqn gtteevtsee eeeeeemaed iedldhyemk eeepisgkks edegiekenl
      181 ailekirktq rqdhlnsy
//
LOCUS       XP_047289307             197 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin-conjugating enzyme E2 Q2 isoform X12 [Homo sapiens].
ACCESSION   XP_047289307
VERSION     XP_047289307.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433351.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..197
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..197
                     /product="ubiquitin-conjugating enzyme E2 Q2 isoform X12"
                     /calculated_mol_wt=22640
     Region          9..>69
                     /region_name="RWD"
                     /note="RWD domain; cl02687"
                     /db_xref="CDD:413438"
     CDS             1..197
                     /gene="UBE2Q2"
                     /coded_by="XM_047433351.1:221..814"
                     /db_xref="GeneID:92912"
                     /db_xref="HGNC:HGNC:19248"
                     /db_xref="MIM:612501"
ORIGIN      
        1 msvsglkael kflasifdkn herfrivswk ldelhcqflv pqqgsphslp ppltlhcnit
       61 esypssspiw fvdsedpnlt svlerledtk nnnllrqqlk wlicelcsly nlpkhldvem
      121 ldqplptgqn gtteevtsee eeeeeemaed iedldhyemk eeepisgkks edegiekenl
      181 ailekirktq rqdhlng
//
LOCUS       XP_011520532             377 aa            linear   PRI 05-AUG-2025
DEFINITION  protein-glutamine gamma-glutamyltransferase 5 isoform X1 [Homo
            sapiens].
ACCESSION   XP_011520532
VERSION     XP_011520532.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522230.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..377
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..377
                     /product="protein-glutamine gamma-glutamyltransferase 5
                     isoform X1"
                     /calculated_mol_wt=41896
     Region          164..263
                     /region_name="Transglut_C"
                     /note="Transglutaminase family, C-terminal ig like domain;
                     pfam00927"
                     /db_xref="CDD:460002"
     Region          277..374
                     /region_name="Transglut_C"
                     /note="Transglutaminase family, C-terminal ig like domain;
                     pfam00927"
                     /db_xref="CDD:460002"
     CDS             1..377
                     /gene="TGM5"
                     /gene_synonym="PSS2; TG(X); TGASE5; TGASEX; TGM6; TGMX;
                     TGX"
                     /coded_by="XM_011522230.3:233..1366"
                     /db_xref="GeneID:9333"
                     /db_xref="HGNC:HGNC:11781"
                     /db_xref="MIM:603805"
ORIGIN      
        1 markdlppay ggwqvldatp qemsngvycc gpasvraike gevdlnydtp fvfsmvnadc
       61 mswlvqggke qklhqdtssv gnfistksiq sderdditen ykyeegslqe rqvflkalqk
      121 lkarsfhgsq rgaelqpsrp tslsqdsprs lhtpslrpsd vvqvslkfkl ldppnmgqdi
      181 cfvllalnms sqfkdlkvnl saqsllhdgs plspfwqdta fitlspkeak typckisysq
      241 ysqylstdkl irisalgeek sspekilvnk iitlsypsit invlgaavvn qplsiqvifs
      301 nplseqvedc vltvegsglf kkqqkvflgv lkpqhqasii letvpfksgq rqiqanmrsn
      361 kfkdikgyrn vyvdfal
//
LOCUS       XP_006720838             364 aa            linear   PRI 05-AUG-2025
DEFINITION  homer protein homolog 2 isoform X1 [Homo sapiens].
ACCESSION   XP_006720838
VERSION     XP_006720838.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720775.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..364
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..364
                     /product="homer protein homolog 2 isoform X1"
                     /calculated_mol_wt=41845
     Region          13..121
                     /region_name="EVH1_Homer_Vesl"
                     /note="Homer/Vesl family proteins EVH1 domain; cd01206"
                     /db_xref="CDD:269917"
     Site            order(34,80,84,99)
                     /site_type="other"
                     /note="proline-rich peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:269917"
     Region          <103..343
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..364
                     /gene="HOMER2"
                     /gene_synonym="ACPD; CPD; DFNA68; HOMER-2; VESL-2"
                     /coded_by="XM_006720775.4:479..1573"
                     /db_xref="GeneID:9455"
                     /db_xref="HGNC:HGNC:17513"
                     /db_xref="MIM:604799"
ORIGIN      
        1 mlkmmevyke preqpifttr ahvfqidpnt kknwmpaskq avtvsyfydv trnsyriisv
       61 dgakviinst itpnmtftkt sqkfgqwads rantvfglgf sseqqltkfa ekfqevkeaa
      121 kiakdktqek ietssnhsqe sgretpsstq assvngtdde kashagpant hlksendklk
      181 ialtqsaanv kkweielqtl resnarltta lqesaasveq wkrqfsicrd endrlrnkid
      241 eleeqcsein rekekntqlk rrieeleael reketelkdl rkqseiipql mseceyvsek
      301 leaaerdnqn ledkvrslkt dieeskyrqr hlkvelksfl evldgkiddl hdfrrglskl
      361 gtdn
//
LOCUS       XP_011520534             364 aa            linear   PRI 05-AUG-2025
DEFINITION  homer protein homolog 2 isoform X1 [Homo sapiens].
ACCESSION   XP_011520534
VERSION     XP_011520534.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522232.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..364
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..364
                     /product="homer protein homolog 2 isoform X1"
                     /calculated_mol_wt=41845
     Region          13..121
                     /region_name="EVH1_Homer_Vesl"
                     /note="Homer/Vesl family proteins EVH1 domain; cd01206"
                     /db_xref="CDD:269917"
     Site            order(34,80,84,99)
                     /site_type="other"
                     /note="proline-rich peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:269917"
     Region          <103..343
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..364
                     /gene="HOMER2"
                     /gene_synonym="ACPD; CPD; DFNA68; HOMER-2; VESL-2"
                     /coded_by="XM_011522232.3:479..1573"
                     /db_xref="GeneID:9455"
                     /db_xref="HGNC:HGNC:17513"
                     /db_xref="MIM:604799"
ORIGIN      
        1 mlkmmevyke preqpifttr ahvfqidpnt kknwmpaskq avtvsyfydv trnsyriisv
       61 dgakviinst itpnmtftkt sqkfgqwads rantvfglgf sseqqltkfa ekfqevkeaa
      121 kiakdktqek ietssnhsqe sgretpsstq assvngtdde kashagpant hlksendklk
      181 ialtqsaanv kkweielqtl resnarltta lqesaasveq wkrqfsicrd endrlrnkid
      241 eleeqcsein rekekntqlk rrieeleael reketelkdl rkqseiipql mseceyvsek
      301 leaaerdnqn ledkvrslkt dieeskyrqr hlkvelksfl evldgkiddl hdfrrglskl
      361 gtdn
//
LOCUS       XP_011520535             362 aa            linear   PRI 05-AUG-2025
DEFINITION  homer protein homolog 2 isoform X2 [Homo sapiens].
ACCESSION   XP_011520535
VERSION     XP_011520535.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522233.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..362
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..362
                     /product="homer protein homolog 2 isoform X2"
                     /calculated_mol_wt=41376
     Region          11..119
                     /region_name="EVH1_Homer_Vesl"
                     /note="Homer/Vesl family proteins EVH1 domain; cd01206"
                     /db_xref="CDD:269917"
     Site            order(32,78,82,97)
                     /site_type="other"
                     /note="proline-rich peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:269917"
     Region          <101..341
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..362
                     /gene="HOMER2"
                     /gene_synonym="ACPD; CPD; DFNA68; HOMER-2; VESL-2"
                     /coded_by="XM_011522233.4:16..1104"
                     /db_xref="GeneID:9455"
                     /db_xref="HGNC:HGNC:17513"
                     /db_xref="MIM:604799"
ORIGIN      
        1 mgpgarwvgr eqpifttrah vfqidpntkk nwmpaskqav tvsyfydvtr nsyriisvdg
       61 akviinstit pnmtftktsq kfgqwadsra ntvfglgfss eqqltkfaek fqevkeaaki
      121 akdktqekie tssnhsqesg retpsstqas svngtddeka shagpanthl ksendklkia
      181 ltqsaanvkk weielqtlre snarlttalq esaasveqwk rqfsicrden drlrnkidel
      241 eeqcseinre kekntqlkrr ieeleaelre ketelkdlrk qseiipqlms eceyvsekle
      301 aaerdnqnle dkvrslktdi eeskyrqrhl kvelksflev ldgkiddlhd frrglsklgt
      361 dn
//
LOCUS       XP_006720839             354 aa            linear   PRI 05-AUG-2025
DEFINITION  homer protein homolog 2 isoform X3 [Homo sapiens].
ACCESSION   XP_006720839
VERSION     XP_006720839.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_006720776.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..354
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..354
                     /product="homer protein homolog 2 isoform X3"
                     /calculated_mol_wt=40595
     Region          3..111
                     /region_name="EVH1_Homer_Vesl"
                     /note="Homer/Vesl family proteins EVH1 domain; cd01206"
                     /db_xref="CDD:269917"
     Site            order(24,70,74,89)
                     /site_type="other"
                     /note="proline-rich peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:269917"
     Region          <93..333
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..354
                     /gene="HOMER2"
                     /gene_synonym="ACPD; CPD; DFNA68; HOMER-2; VESL-2"
                     /coded_by="XM_006720776.5:74..1138"
                     /db_xref="GeneID:9455"
                     /db_xref="HGNC:HGNC:17513"
                     /db_xref="MIM:604799"
ORIGIN      
        1 mreqpifttr ahvfqidpnt kknwmpaskq avtvsyfydv trnsyriisv dgakviinst
       61 itpnmtftkt sqkfgqwads rantvfglgf sseqqltkfa ekfqevkeaa kiakdktqek
      121 ietssnhsqe sgretpsstq assvngtdde kashagpant hlksendklk ialtqsaanv
      181 kkweielqtl resnarltta lqesaasveq wkrqfsicrd endrlrnkid eleeqcsein
      241 rekekntqlk rrieeleael reketelkdl rkqseiipql mseceyvsek leaaerdnqn
      301 ledkvrslkt dieeskyrqr hlkvelksfl evldgkiddl hdfrrglskl gtdn
//
LOCUS       XP_047289311             354 aa            linear   PRI 05-AUG-2025
DEFINITION  homer protein homolog 2 isoform X4 [Homo sapiens].
ACCESSION   XP_047289311
VERSION     XP_047289311.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433355.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..354
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..354
                     /product="homer protein homolog 2 isoform X4"
                     /calculated_mol_wt=40496
     Region          3..111
                     /region_name="EVH1_Homer_Vesl"
                     /note="Homer/Vesl family proteins EVH1 domain; cd01206"
                     /db_xref="CDD:269917"
     Site            order(24,70,74,89)
                     /site_type="other"
                     /note="proline-rich peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:269917"
     Region          <93..333
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..354
                     /gene="HOMER2"
                     /gene_synonym="ACPD; CPD; DFNA68; HOMER-2; VESL-2"
                     /coded_by="XM_047433355.1:186..1250"
                     /db_xref="GeneID:9455"
                     /db_xref="HGNC:HGNC:17513"
                     /db_xref="MIM:604799"
ORIGIN      
        1 mgeqpifttr ahvfqidpnt kknwmpaskq avtvsyfydv trnsyriisv dgakviinst
       61 itpnmtftkt sqkfgqwads rantvfglgf sseqqltkfa ekfqevkeaa kiakdktqek
      121 ietssnhsqe sgretpsstq assvngtdde kashagpant hlksendklk ialtqsaanv
      181 kkweielqtl resnarltta lqesaasveq wkrqfsicrd endrlrnkid eleeqcsein
      241 rekekntqlk rrieeleael reketelkdl rkqseiipql mseceyvsek leaaerdnqn
      301 ledkvrslkt dieeskyrqr hlkvelksfl evldgkiddl hdfrrglskl gtdn
//
LOCUS       XP_047289312             353 aa            linear   PRI 05-AUG-2025
DEFINITION  homer protein homolog 2 isoform X5 [Homo sapiens].
ACCESSION   XP_047289312
VERSION     XP_047289312.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433356.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..353
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..353
                     /product="homer protein homolog 2 isoform X5"
                     /calculated_mol_wt=40685
     Region          13..121
                     /region_name="EVH1_Homer_Vesl"
                     /note="Homer/Vesl family proteins EVH1 domain; cd01206"
                     /db_xref="CDD:269917"
     Site            order(34,80,84,99)
                     /site_type="other"
                     /note="proline-rich peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:269917"
     Region          <103..332
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..353
                     /gene="HOMER2"
                     /gene_synonym="ACPD; CPD; DFNA68; HOMER-2; VESL-2"
                     /coded_by="XM_047433356.1:479..1540"
                     /db_xref="GeneID:9455"
                     /db_xref="HGNC:HGNC:17513"
                     /db_xref="MIM:604799"
ORIGIN      
        1 mlkmmevyke preqpifttr ahvfqidpnt kknwmpaskq avtvsyfydv trnsyriisv
       61 dgakviinst itpnmtftkt sqkfgqwads rantvfglgf sseqqltkfa ekfqevkeaa
      121 kiakdktqek ietssnhsqa ssvngtddek ashagpanth lksendklki altqsaanvk
      181 kweielqtlr esnarlttal qesaasveqw krqfsicrde ndrlrnkide leeqcseinr
      241 ekekntqlkr rieeleaelr eketelkdlr kqseiipqlm seceyvsekl eaaerdnqnl
      301 edkvrslktd ieeskyrqrh lkvelksfle vldgkiddlh dfrrglsklg tdn
//
LOCUS       XP_047289313             353 aa            linear   PRI 05-AUG-2025
DEFINITION  homer protein homolog 2 isoform X5 [Homo sapiens].
ACCESSION   XP_047289313
VERSION     XP_047289313.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433357.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..353
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..353
                     /product="homer protein homolog 2 isoform X5"
                     /calculated_mol_wt=40685
     Region          13..121
                     /region_name="EVH1_Homer_Vesl"
                     /note="Homer/Vesl family proteins EVH1 domain; cd01206"
                     /db_xref="CDD:269917"
     Site            order(34,80,84,99)
                     /site_type="other"
                     /note="proline-rich peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:269917"
     Region          <103..332
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..353
                     /gene="HOMER2"
                     /gene_synonym="ACPD; CPD; DFNA68; HOMER-2; VESL-2"
                     /coded_by="XM_047433357.1:479..1540"
                     /db_xref="GeneID:9455"
                     /db_xref="HGNC:HGNC:17513"
                     /db_xref="MIM:604799"
ORIGIN      
        1 mlkmmevyke preqpifttr ahvfqidpnt kknwmpaskq avtvsyfydv trnsyriisv
       61 dgakviinst itpnmtftkt sqkfgqwads rantvfglgf sseqqltkfa ekfqevkeaa
      121 kiakdktqek ietssnhsqa ssvngtddek ashagpanth lksendklki altqsaanvk
      181 kweielqtlr esnarlttal qesaasveqw krqfsicrde ndrlrnkide leeqcseinr
      241 ekekntqlkr rieeleaelr eketelkdlr kqseiipqlm seceyvsekl eaaerdnqnl
      301 edkvrslktd ieeskyrqrh lkvelksfle vldgkiddlh dfrrglsklg tdn
//
LOCUS       XP_005272506             343 aa            linear   PRI 05-AUG-2025
DEFINITION  homer protein homolog 2 isoform X6 [Homo sapiens].
ACCESSION   XP_005272506
VERSION     XP_005272506.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005272449.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..343
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..343
                     /product="homer protein homolog 2 isoform X6"
                     /calculated_mol_wt=39435
     Region          3..111
                     /region_name="EVH1_Homer_Vesl"
                     /note="Homer/Vesl family proteins EVH1 domain; cd01206"
                     /db_xref="CDD:269917"
     Site            order(24,70,74,89)
                     /site_type="other"
                     /note="proline-rich peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:269917"
     Region          <93..322
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..343
                     /gene="HOMER2"
                     /gene_synonym="ACPD; CPD; DFNA68; HOMER-2; VESL-2"
                     /coded_by="XM_005272449.5:74..1105"
                     /db_xref="GeneID:9455"
                     /db_xref="HGNC:HGNC:17513"
                     /db_xref="MIM:604799"
ORIGIN      
        1 mreqpifttr ahvfqidpnt kknwmpaskq avtvsyfydv trnsyriisv dgakviinst
       61 itpnmtftkt sqkfgqwads rantvfglgf sseqqltkfa ekfqevkeaa kiakdktqek
      121 ietssnhsqa ssvngtddek ashagpanth lksendklki altqsaanvk kweielqtlr
      181 esnarlttal qesaasveqw krqfsicrde ndrlrnkide leeqcseinr ekekntqlkr
      241 rieeleaelr eketelkdlr kqseiipqlm seceyvsekl eaaerdnqnl edkvrslktd
      301 ieeskyrqrh lkvelksfle vldgkiddlh dfrrglsklg tdn
//
LOCUS       XP_047289314             343 aa            linear   PRI 05-AUG-2025
DEFINITION  homer protein homolog 2 isoform X7 [Homo sapiens].
ACCESSION   XP_047289314
VERSION     XP_047289314.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433358.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..343
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..343
                     /product="homer protein homolog 2 isoform X7"
                     /calculated_mol_wt=39336
     Region          3..111
                     /region_name="EVH1_Homer_Vesl"
                     /note="Homer/Vesl family proteins EVH1 domain; cd01206"
                     /db_xref="CDD:269917"
     Site            order(24,70,74,89)
                     /site_type="other"
                     /note="proline-rich peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:269917"
     Region          <93..322
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..343
                     /gene="HOMER2"
                     /gene_synonym="ACPD; CPD; DFNA68; HOMER-2; VESL-2"
                     /coded_by="XM_047433358.1:186..1217"
                     /db_xref="GeneID:9455"
                     /db_xref="HGNC:HGNC:17513"
                     /db_xref="MIM:604799"
ORIGIN      
        1 mgeqpifttr ahvfqidpnt kknwmpaskq avtvsyfydv trnsyriisv dgakviinst
       61 itpnmtftkt sqkfgqwads rantvfglgf sseqqltkfa ekfqevkeaa kiakdktqek
      121 ietssnhsqa ssvngtddek ashagpanth lksendklki altqsaanvk kweielqtlr
      181 esnarlttal qesaasveqw krqfsicrde ndrlrnkide leeqcseinr ekekntqlkr
      241 rieeleaelr eketelkdlr kqseiipqlm seceyvsekl eaaerdnqnl edkvrslktd
      301 ieeskyrqrh lkvelksfle vldgkiddlh dfrrglsklg tdn
//
LOCUS       XP_047289315             343 aa            linear   PRI 05-AUG-2025
DEFINITION  homer protein homolog 2 isoform X7 [Homo sapiens].
ACCESSION   XP_047289315
VERSION     XP_047289315.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433359.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..343
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..343
                     /product="homer protein homolog 2 isoform X7"
                     /calculated_mol_wt=39336
     Region          3..111
                     /region_name="EVH1_Homer_Vesl"
                     /note="Homer/Vesl family proteins EVH1 domain; cd01206"
                     /db_xref="CDD:269917"
     Site            order(24,70,74,89)
                     /site_type="other"
                     /note="proline-rich peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:269917"
     Region          <93..322
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..343
                     /gene="HOMER2"
                     /gene_synonym="ACPD; CPD; DFNA68; HOMER-2; VESL-2"
                     /coded_by="XM_047433359.1:186..1217"
                     /db_xref="GeneID:9455"
                     /db_xref="HGNC:HGNC:17513"
                     /db_xref="MIM:604799"
ORIGIN      
        1 mgeqpifttr ahvfqidpnt kknwmpaskq avtvsyfydv trnsyriisv dgakviinst
       61 itpnmtftkt sqkfgqwads rantvfglgf sseqqltkfa ekfqevkeaa kiakdktqek
      121 ietssnhsqa ssvngtddek ashagpanth lksendklki altqsaanvk kweielqtlr
      181 esnarlttal qesaasveqw krqfsicrde ndrlrnkide leeqcseinr ekekntqlkr
      241 rieeleaelr eketelkdlr kqseiipqlm seceyvsekl eaaerdnqnl edkvrslktd
      301 ieeskyrqrh lkvelksfle vldgkiddlh dfrrglsklg tdn
//
LOCUS       XP_047289316             330 aa            linear   PRI 05-AUG-2025
DEFINITION  homer protein homolog 2 isoform X8 [Homo sapiens].
ACCESSION   XP_047289316
VERSION     XP_047289316.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433360.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..330
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..330
                     /product="homer protein homolog 2 isoform X8"
                     /calculated_mol_wt=37655
     Region          <2..87
                     /region_name="EVH1_Homer_Vesl"
                     /note="Homer/Vesl family proteins EVH1 domain; cd01206"
                     /db_xref="CDD:269917"
     Region          <69..309
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..330
                     /gene="HOMER2"
                     /gene_synonym="ACPD; CPD; DFNA68; HOMER-2; VESL-2"
                     /coded_by="XM_047433360.1:358..1350"
                     /db_xref="GeneID:9455"
                     /db_xref="HGNC:HGNC:17513"
                     /db_xref="MIM:604799"
ORIGIN      
        1 mpaskqavtv syfydvtrns yriisvdgak viinstitpn mtftktsqkf gqwadsrant
       61 vfglgfsseq qltkfaekfq evkeaakiak dktqekiets snhsqesgre tpsstqassv
      121 ngtddekash agpanthlks endklkialt qsaanvkkwe ielqtlresn arlttalqes
      181 aasveqwkrq fsicrdendr lrnkidelee qcseinreke kntqlkrrie eleaelreke
      241 telkdlrkqs eiipqlmsec eyvsekleaa erdnqnledk vrslktdiee skyrqrhlkv
      301 elksflevld gkiddlhdfr rglsklgtdn
//
LOCUS       XP_047289317             330 aa            linear   PRI 05-AUG-2025
DEFINITION  homer protein homolog 2 isoform X8 [Homo sapiens].
ACCESSION   XP_047289317
VERSION     XP_047289317.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433361.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..330
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..330
                     /product="homer protein homolog 2 isoform X8"
                     /calculated_mol_wt=37655
     Region          <2..87
                     /region_name="EVH1_Homer_Vesl"
                     /note="Homer/Vesl family proteins EVH1 domain; cd01206"
                     /db_xref="CDD:269917"
     Region          <69..309
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..330
                     /gene="HOMER2"
                     /gene_synonym="ACPD; CPD; DFNA68; HOMER-2; VESL-2"
                     /coded_by="XM_047433361.1:773..1765"
                     /db_xref="GeneID:9455"
                     /db_xref="HGNC:HGNC:17513"
                     /db_xref="MIM:604799"
ORIGIN      
        1 mpaskqavtv syfydvtrns yriisvdgak viinstitpn mtftktsqkf gqwadsrant
       61 vfglgfsseq qltkfaekfq evkeaakiak dktqekiets snhsqesgre tpsstqassv
      121 ngtddekash agpanthlks endklkialt qsaanvkkwe ielqtlresn arlttalqes
      181 aasveqwkrq fsicrdendr lrnkidelee qcseinreke kntqlkrrie eleaelreke
      241 telkdlrkqs eiipqlmsec eyvsekleaa erdnqnledk vrslktdiee skyrqrhlkv
      301 elksflevld gkiddlhdfr rglsklgtdn
//
LOCUS       XP_047289318             330 aa            linear   PRI 05-AUG-2025
DEFINITION  homer protein homolog 2 isoform X8 [Homo sapiens].
ACCESSION   XP_047289318
VERSION     XP_047289318.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433362.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..330
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..330
                     /product="homer protein homolog 2 isoform X8"
                     /calculated_mol_wt=37655
     Region          <2..87
                     /region_name="EVH1_Homer_Vesl"
                     /note="Homer/Vesl family proteins EVH1 domain; cd01206"
                     /db_xref="CDD:269917"
     Region          <69..309
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..330
                     /gene="HOMER2"
                     /gene_synonym="ACPD; CPD; DFNA68; HOMER-2; VESL-2"
                     /coded_by="XM_047433362.1:1604..2596"
                     /db_xref="GeneID:9455"
                     /db_xref="HGNC:HGNC:17513"
                     /db_xref="MIM:604799"
ORIGIN      
        1 mpaskqavtv syfydvtrns yriisvdgak viinstitpn mtftktsqkf gqwadsrant
       61 vfglgfsseq qltkfaekfq evkeaakiak dktqekiets snhsqesgre tpsstqassv
      121 ngtddekash agpanthlks endklkialt qsaanvkkwe ielqtlresn arlttalqes
      181 aasveqwkrq fsicrdendr lrnkidelee qcseinreke kntqlkrrie eleaelreke
      241 telkdlrkqs eiipqlmsec eyvsekleaa erdnqnledk vrslktdiee skyrqrhlkv
      301 elksflevld gkiddlhdfr rglsklgtdn
//
LOCUS       XP_011520537             539 aa            linear   PRI 05-AUG-2025
DEFINITION  GPI alpha-1,2-mannosyltransferase 3 isoform X1 [Homo sapiens].
ACCESSION   XP_011520537
VERSION     XP_011520537.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522235.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..539
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..539
                     /product="GPI alpha-1,2-mannosyltransferase 3 isoform X1"
                     /calculated_mol_wt=63046
     Region          62..434
                     /region_name="Glyco_transf_22"
                     /note="Alg9-like mannosyltransferase family; pfam03901"
                     /db_xref="CDD:281842"
     CDS             1..539
                     /gene="PIGB"
                     /gene_synonym="DEE80; EIEE80; GPI-MT-III; PIG-B"
                     /coded_by="XM_011522235.4:30..1649"
                     /db_xref="GeneID:9488"
                     /db_xref="HGNC:HGNC:8959"
                     /db_xref="MIM:604122"
ORIGIN      
        1 mrrplskcgm epgggdaslt lhglqnrshg kiklrkrkst lyfntqeksa rrrgdllgen
       61 iylllftial rilncflvqt sfvpdeywqs levshhmvfn ygyltwewte rlrsytypli
      121 fasiykilhl lgkdsvqlli wiprlaqall savadvrlys lmkqlenqev arwvffcqlc
      181 swftwycctr tltntmetvl tiialfyypl egsksmnsvk ysslvalafi irptavilwt
      241 pllfrhfcqe prkldlilhh flpvgfvtls lslmidriff gqnwgtfygs hpwhwyfsqg
      301 fpvilgthlp ffihgcylap kryrillvtv lwtllvysml shkefrfiyp vlpfcmvfcg
      361 yslthlktwk kpalsflfls nlflalytgl vhqrgtldvm shiqkvcynn pnkssasifi
      421 mmpchstpyy shvhcplpmr flqcppdltg kshyldeadv fylnplnwlh refhddaslp
      481 thlitfsile eeisafliss nykrtavffh thlpegrigs hiyvyerklk gkfnmkmkf
//
LOCUS       XP_011520538             519 aa            linear   PRI 05-AUG-2025
DEFINITION  GPI alpha-1,2-mannosyltransferase 3 isoform X2 [Homo sapiens].
ACCESSION   XP_011520538
VERSION     XP_011520538.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522236.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..519
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..519
                     /product="GPI alpha-1,2-mannosyltransferase 3 isoform X2"
                     /calculated_mol_wt=60862
     Region          62..414
                     /region_name="Glyco_transf_22"
                     /note="Alg9-like mannosyltransferase family; pfam03901"
                     /db_xref="CDD:281842"
     CDS             1..519
                     /gene="PIGB"
                     /gene_synonym="DEE80; EIEE80; GPI-MT-III; PIG-B"
                     /coded_by="XM_011522236.4:30..1589"
                     /db_xref="GeneID:9488"
                     /db_xref="HGNC:HGNC:8959"
                     /db_xref="MIM:604122"
ORIGIN      
        1 mrrplskcgm epgggdaslt lhglqnrshg kiklrkrkst lyfntqeksa rrrgdllgen
       61 iylllftial rilncflvqt sfvpdeywqs levshhmvfn ygyltwewte rlrsytypli
      121 fasiykilhl lgkdsvqllf fcqlcswftw ycctrtltnt metvltiial fyyplegsks
      181 mnsvkysslv alafiirpta vilwtpllfr hfcqeprkld lilhhflpvg fvtlslslmi
      241 driffgqwtl vqfnflkfnv lqnwgtfygs hpwhwyfsqg fpvilgthlp ffihgcylap
      301 kryrillvtv lwtllvysml shkefrfiyp vlpfcmvfcg yslthlktwk kpalsflfls
      361 nlflalytgl vhqrgtldvm shiqkvcynn pnkssasifi mmpchstpyy shvhcplpmr
      421 flqcppdltg kshyldeadv fylnplnwlh refhddaslp thlitfsile eeisafliss
      481 nykrtavffh thlpegrigs hiyvyerklk gkfnmkmkf
//
LOCUS       XP_016878219             421 aa            linear   PRI 05-AUG-2025
DEFINITION  GPI alpha-1,2-mannosyltransferase 3 isoform X3 [Homo sapiens].
ACCESSION   XP_016878219
VERSION     XP_016878219.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022730.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..421
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..421
                     /product="GPI alpha-1,2-mannosyltransferase 3 isoform X3"
                     /calculated_mol_wt=49405
     Region          7..316
                     /region_name="PMT_2"
                     /note="Dolichyl-phosphate-mannose-protein
                     mannosyltransferase; cl21590"
                     /db_xref="CDD:473917"
     CDS             1..421
                     /gene="PIGB"
                     /gene_synonym="DEE80; EIEE80; GPI-MT-III; PIG-B"
                     /coded_by="XM_017022730.1:135..1400"
                     /db_xref="GeneID:9488"
                     /db_xref="HGNC:HGNC:8959"
                     /db_xref="MIM:604122"
ORIGIN      
        1 mqskqkiwip rlaqallsav advrlyslmk qlenqevarw vffcqlcswf twycctrtlt
       61 ntmetvltii alfyyplegs ksmnsvkyss lvalafiirp tavilwtpll frhfcqeprk
      121 ldlilhhflp vgfvtlslsl midriffgqw tlvqfnflkf nvlqnwgtfy gshpwhwyfs
      181 qgfpvilgth lpffihgcyl apkryrillv tvlwtllvys mlshkefrfi ypvlpfcmvf
      241 cgyslthlkt wkkpalsflf lsnlflalyt glvhqrgtld vmshiqkvcy nnpnkssasi
      301 fimmpchstp yyshvhcplp mrflqcppdl tgkshyldea dvfylnplnw lhrefhddas
      361 lpthlitfsi leeeisafli ssnykrtavf fhthlpegri gshiyvyerk lkgkfnmkmk
      421 f
//
LOCUS       XP_016878220             421 aa            linear   PRI 05-AUG-2025
DEFINITION  GPI alpha-1,2-mannosyltransferase 3 isoform X3 [Homo sapiens].
ACCESSION   XP_016878220
VERSION     XP_016878220.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_017022731.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..421
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..421
                     /product="GPI alpha-1,2-mannosyltransferase 3 isoform X3"
                     /calculated_mol_wt=49405
     Region          7..316
                     /region_name="PMT_2"
                     /note="Dolichyl-phosphate-mannose-protein
                     mannosyltransferase; cl21590"
                     /db_xref="CDD:473917"
     CDS             1..421
                     /gene="PIGB"
                     /gene_synonym="DEE80; EIEE80; GPI-MT-III; PIG-B"
                     /coded_by="XM_017022731.2:260..1525"
                     /db_xref="GeneID:9488"
                     /db_xref="HGNC:HGNC:8959"
                     /db_xref="MIM:604122"
ORIGIN      
        1 mqskqkiwip rlaqallsav advrlyslmk qlenqevarw vffcqlcswf twycctrtlt
       61 ntmetvltii alfyyplegs ksmnsvkyss lvalafiirp tavilwtpll frhfcqeprk
      121 ldlilhhflp vgfvtlslsl midriffgqw tlvqfnflkf nvlqnwgtfy gshpwhwyfs
      181 qgfpvilgth lpffihgcyl apkryrillv tvlwtllvys mlshkefrfi ypvlpfcmvf
      241 cgyslthlkt wkkpalsflf lsnlflalyt glvhqrgtld vmshiqkvcy nnpnkssasi
      301 fimmpchstp yyshvhcplp mrflqcppdl tgkshyldea dvfylnplnw lhrefhddas
      361 lpthlitfsi leeeisafli ssnykrtavf fhthlpegri gshiyvyerk lkgkfnmkmk
      421 f
//
LOCUS       XP_047289319             421 aa            linear   PRI 05-AUG-2025
DEFINITION  GPI alpha-1,2-mannosyltransferase 3 isoform X3 [Homo sapiens].
ACCESSION   XP_047289319
VERSION     XP_047289319.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433363.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 8% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..421
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..421
                     /product="GPI alpha-1,2-mannosyltransferase 3 isoform X3"
                     /calculated_mol_wt=49405
     Region          7..316
                     /region_name="PMT_2"
                     /note="Dolichyl-phosphate-mannose-protein
                     mannosyltransferase; cl21590"
                     /db_xref="CDD:473917"
     CDS             1..421
                     /gene="PIGB"
                     /gene_synonym="DEE80; EIEE80; GPI-MT-III; PIG-B"
                     /coded_by="XM_047433363.1:391..1656"
                     /db_xref="GeneID:9488"
                     /db_xref="HGNC:HGNC:8959"
                     /db_xref="MIM:604122"
ORIGIN      
        1 mqskqkiwip rlaqallsav advrlyslmk qlenqevarw vffcqlcswf twycctrtlt
       61 ntmetvltii alfyyplegs ksmnsvkyss lvalafiirp tavilwtpll frhfcqeprk
      121 ldlilhhflp vgfvtlslsl midriffgqw tlvqfnflkf nvlqnwgtfy gshpwhwyfs
      181 qgfpvilgth lpffihgcyl apkryrillv tvlwtllvys mlshkefrfi ypvlpfcmvf
      241 cgyslthlkt wkkpalsflf lsnlflalyt glvhqrgtld vmshiqkvcy nnpnkssasi
      301 fimmpchstp yyshvhcplp mrflqcppdl tgkshyldea dvfylnplnw lhrefhddas
      361 lpthlitfsi leeeisafli ssnykrtavf fhthlpegri gshiyvyerk lkgkfnmkmk
      421 f
//
LOCUS       XP_011520539             421 aa            linear   PRI 05-AUG-2025
DEFINITION  GPI alpha-1,2-mannosyltransferase 3 isoform X3 [Homo sapiens].
ACCESSION   XP_011520539
VERSION     XP_011520539.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_011522237.3
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 8% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..421
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..421
                     /product="GPI alpha-1,2-mannosyltransferase 3 isoform X3"
                     /calculated_mol_wt=49405
     Region          7..316
                     /region_name="PMT_2"
                     /note="Dolichyl-phosphate-mannose-protein
                     mannosyltransferase; cl21590"
                     /db_xref="CDD:473917"
     CDS             1..421
                     /gene="PIGB"
                     /gene_synonym="DEE80; EIEE80; GPI-MT-III; PIG-B"
                     /coded_by="XM_011522237.3:230..1495"
                     /db_xref="GeneID:9488"
                     /db_xref="HGNC:HGNC:8959"
                     /db_xref="MIM:604122"
ORIGIN      
        1 mqskqkiwip rlaqallsav advrlyslmk qlenqevarw vffcqlcswf twycctrtlt
       61 ntmetvltii alfyyplegs ksmnsvkyss lvalafiirp tavilwtpll frhfcqeprk
      121 ldlilhhflp vgfvtlslsl midriffgqw tlvqfnflkf nvlqnwgtfy gshpwhwyfs
      181 qgfpvilgth lpffihgcyl apkryrillv tvlwtllvys mlshkefrfi ypvlpfcmvf
      241 cgyslthlkt wkkpalsflf lsnlflalyt glvhqrgtld vmshiqkvcy nnpnkssasi
      301 fimmpchstp yyshvhcplp mrflqcppdl tgkshyldea dvfylnplnw lhrefhddas
      361 lpthlitfsi leeeisafli ssnykrtavf fhthlpegri gshiyvyerk lkgkfnmkmk
      421 f
//
LOCUS       XP_005254852             393 aa            linear   PRI 05-AUG-2025
DEFINITION  GPI alpha-1,2-mannosyltransferase 3 isoform X4 [Homo sapiens].
ACCESSION   XP_005254852
VERSION     XP_005254852.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254795.6
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 8% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..393
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..393
                     /product="GPI alpha-1,2-mannosyltransferase 3 isoform X4"
                     /calculated_mol_wt=46223
     Region          <1..288
                     /region_name="PMT_2"
                     /note="Dolichyl-phosphate-mannose-protein
                     mannosyltransferase; cl21590"
                     /db_xref="CDD:473917"
     CDS             1..393
                     /gene="PIGB"
                     /gene_synonym="DEE80; EIEE80; GPI-MT-III; PIG-B"
                     /coded_by="XM_005254795.6:259..1440"
                     /db_xref="GeneID:9488"
                     /db_xref="HGNC:HGNC:8959"
                     /db_xref="MIM:604122"
ORIGIN      
        1 mkqlenqeva rwvffcqlcs wftwycctrt ltntmetvlt iialfyyple gsksmnsvky
       61 sslvalafii rptavilwtp llfrhfcqep rkldlilhhf lpvgfvtlsl slmidriffg
      121 qwtlvqfnfl kfnvlqnwgt fygshpwhwy fsqgfpvilg thlpffihgc ylapkryril
      181 lvtvlwtllv ysmlshkefr fiypvlpfcm vfcgyslthl ktwkkpalsf lflsnlflal
      241 ytglvhqrgt ldvmshiqkv cynnpnkssa sifimmpchs tpyyshvhcp lpmrflqcpp
      301 dltgkshyld eadvfylnpl nwlhrefhdd aslpthlitf sileeeisaf lissnykrta
      361 vffhthlpeg rigshiyvye rklkgkfnmk mkf
//
LOCUS       XP_047289320             393 aa            linear   PRI 05-AUG-2025
DEFINITION  GPI alpha-1,2-mannosyltransferase 3 isoform X4 [Homo sapiens].
ACCESSION   XP_047289320
VERSION     XP_047289320.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433364.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 8% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..393
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..393
                     /product="GPI alpha-1,2-mannosyltransferase 3 isoform X4"
                     /calculated_mol_wt=46223
     Region          <1..288
                     /region_name="PMT_2"
                     /note="Dolichyl-phosphate-mannose-protein
                     mannosyltransferase; cl21590"
                     /db_xref="CDD:473917"
     CDS             1..393
                     /gene="PIGB"
                     /gene_synonym="DEE80; EIEE80; GPI-MT-III; PIG-B"
                     /coded_by="XM_047433364.1:420..1601"
                     /db_xref="GeneID:9488"
                     /db_xref="HGNC:HGNC:8959"
                     /db_xref="MIM:604122"
ORIGIN      
        1 mkqlenqeva rwvffcqlcs wftwycctrt ltntmetvlt iialfyyple gsksmnsvky
       61 sslvalafii rptavilwtp llfrhfcqep rkldlilhhf lpvgfvtlsl slmidriffg
      121 qwtlvqfnfl kfnvlqnwgt fygshpwhwy fsqgfpvilg thlpffihgc ylapkryril
      181 lvtvlwtllv ysmlshkefr fiypvlpfcm vfcgyslthl ktwkkpalsf lflsnlflal
      241 ytglvhqrgt ldvmshiqkv cynnpnkssa sifimmpchs tpyyshvhcp lpmrflqcpp
      301 dltgkshyld eadvfylnpl nwlhrefhdd aslpthlitf sileeeisaf lissnykrta
      361 vffhthlpeg rigshiyvye rklkgkfnmk mkf
//
LOCUS       XP_047289321             382 aa            linear   PRI 05-AUG-2025
DEFINITION  GPI alpha-1,2-mannosyltransferase 3 isoform X5 [Homo sapiens].
ACCESSION   XP_047289321
VERSION     XP_047289321.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_047433365.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..382
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..382
                     /product="GPI alpha-1,2-mannosyltransferase 3 isoform X5"
                     /calculated_mol_wt=44877
     Region          62..381
                     /region_name="Glyco_transf_22"
                     /note="Alg9-like mannosyltransferase family; pfam03901"
                     /db_xref="CDD:281842"
     CDS             1..382
                     /gene="PIGB"
                     /gene_synonym="DEE80; EIEE80; GPI-MT-III; PIG-B"
                     /coded_by="XM_047433365.1:30..1178"
                     /db_xref="GeneID:9488"
                     /db_xref="HGNC:HGNC:8959"
                     /db_xref="MIM:604122"
ORIGIN      
        1 mrrplskcgm epgggdaslt lhglqnrshg kiklrkrkst lyfntqeksa rrrgdllgen
       61 iylllftial rilncflvqt sfvpdeywqs levshhmvfn ygyltwewte rlrsytypli
      121 fasiykilhl lgkdsvqlli wiprlaqall savadvrlys lmkqlenqev arwvffcqlc
      181 swftwycctr tltntmetvl tiialfyypl egsksmnsvk ysslvalafi irptavilwt
      241 pllfrhfcqe prkldlilhh flpvgfvtls lslmidriff gqwtlvqfnf lkfnvlqnwg
      301 tfygshpwhw yfsqgfpvil gthlpffihg cylapkryri llvtvlwtll vysmlshkef
      361 rfiypvlpfc mvfcamftah fp
//
LOCUS       XP_005254854             925 aa            linear   PRI 05-AUG-2025
DEFINITION  kinesin-like protein KIF23 isoform X1 [Homo sapiens].
ACCESSION   XP_005254854
VERSION     XP_005254854.1
DBLINK      BioProject: PRJNA168
DBSOURCE    REFSEQ: accession XM_005254797.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..925
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     Protein         1..925
                     /product="kinesin-like protein KIF23 isoform X1"
                     /calculated_mol_wt=106379
     Region          24..448
                     /region_name="KISc_KIF23_like"
                     /note="Kinesin motor domain, KIF23-like subgroup; cd01368"
                     /db_xref="CDD:276819"
     Site            order(33,112,115,117..120,351)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276819"
     Site            order(403,406,409)
                     /site_type="other"
                     /note="microtubule interaction site [polypeptide binding]"
                     /db_xref="CDD:276819"
     Region          <498..>691
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          817..919
                     /region_name="MKLP1_Arf_bdg"
                     /note="Arf6-interacting domain of mitotic kinesin-like
                     protein 1; pfam16540"
                     /db_xref="CDD:465166"
     CDS             1..925
                     /gene="KIF23"
                     /gene_synonym="CDA3; CDAIII; CDAN3; CDAN3A; CHO1; KNSL5;
                     MKLP-1; MKLP1"
                     /coded_by="XM_005254797.4:118..2895"
                     /db_xref="GeneID:9493"
                     /db_xref="HGNC:HGNC:6392"
                     /db_xref="MIM:605064"
ORIGIN      
        1 mksaraktpr kptvkkgsqt nlkdpvgvyc rvrplgfpdq eccievinnt tvqlhtpegy
       61 rlnrngdyke tqysfkqvfg thttqkelfd vvanplvndl ihgkngllft ygvtgsgkth
      121 tmtgspgegg llprcldmif nsigsfqakr yvfksndrns mdiqcevdal lerqkreamp
      181 npktssskrq vdpefadmit vqefckaeev dedsvygvfv syieiynnyi ydlleevpfd
      241 pikpkwnscs tpmrntdfvp pqskllredk nhnmyvagct evevksteea fevfwrgqkk
      301 rrianthlnr essrshsvfn iklvqaplda dgdnvlqeke qitisqlslv dlagsertnr
      361 traegnrlre agninqslmt lrtcmdvlre nqmygtnkmv pyrdsklthl fknyfdgegk
      421 vrmivcvnpk aedyeenlqv mrfaevtqev evarpvdkai cgltpgrryr nqprgpvgne
      481 plvtdvvlqs fpplpsceil dindeqtlpr liealekrhn lrqmmidefn kqsnafkall
      541 qefdnavlsk enhmqgklne kekmisgqkl eierlekknk tleykieile ktttiyeedk
      601 rnlqqeletq nqklqrqfsd krrlearlqg mvtettmkwe kecerrvaak qlemqnklwv
      661 kdeklkqlka ivtepktekp erpsrerdre kvtqrsvsps pvplssnyia qisngqqlms
      721 qpqlhrrsns cssisvasci seweqkipty ntplkvtsia rrrqqepgqs ktcivsdrrr
      781 gmywtegrev vptfrneiei eedhcgrllf qpdqnappir lrhrrsrsag drwvdhkpas
      841 nmqtetvmqp hvphaitvsv anekalakce kymlthqela sdgeietkli kgdiyktrgg
      901 gqsvqftdie tlkqespngv lwlwr
//
LOCUS       XP_054225046             681 aa            linear   PRI 05-AUG-2025
DEFINITION  PHD finger protein 21A isoform X5 [Homo sapiens].
ACCESSION   XP_054225046
VERSION     XP_054225046.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369071.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..681
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..681
                     /product="PHD finger protein 21A isoform X5"
                     /calculated_mol_wt=74851
     Region          <375..537
                     /region_name="TNG2"
                     /note="Chromatin remodeling protein, contains PhD zinc
                     finger [Chromatin structure and dynamics]; COG5034"
                     /db_xref="CDD:227367"
     Region          491..533
                     /region_name="PHD_PHF21A"
                     /note="PHD finger found in PHD finger protein 21A
                     (PHF21A); cd15523"
                     /db_xref="CDD:276998"
     Site            order(491,498..503,523..526,528)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:276998"
     CDS             1..681
                     /gene="PHF21A"
                     /gene_synonym="BHC80; BM-006; IDDBCS; NEDMS"
                     /coded_by="XM_054369071.1:440..2485"
                     /db_xref="GeneID:51317"
                     /db_xref="HGNC:HGNC:24156"
                     /db_xref="MIM:608325"
ORIGIN      
        1 melqtlqeal kveiqvhqkl vaqmkqdpqn adlkkqlhel qakitalsek qkrvveqlrk
       61 nlivkqeqpd kfqiqplpqs enklqtaqqq plqqlqqqqq yhhhhaqqsa aaspnltasq
      121 ktvttasmit tktlplvlka atatmpasvv gqrptiamvt ainsqkavls tdvqntpvnl
      181 qtsskvtgpg aeavqivakn tvtlqvqatp pqpikvpqfi ppprltprpn flpqvrpkpv
      241 aqnnipiapa pppmlaapql iqrpvmltkf tpttlptsqn sihpvrvvng qtatiaktfp
      301 maqltsivia tpgtrlagpq tvqlskpsle kqtvkshtet dekqtesrti tppaapkpkr
      361 eenpqklafm vslglvthdh leeiqskrqe rkrrttanpv ysgavfeper kksavtylns
      421 tmhpgtrkrg rppkynavlg fgaltptspq sshpdspene ktettftfpa pvqpvslpsp
      481 tstdgdihed fcsvcrksgq llmcdtcsrv yhldcldppl ktipkgmwic prcqdqmlkk
      541 eeaipwpgtl aivhsyiayk aakeeekqkl lkwssdlkqe reqleqkvkq lsnsiskcme
      601 mkntilarqk emhsslekvk qlirlihgid lskpvdseat vgaisngpdc tppanaatst
      661 papspssqsc tancnqgeet k
//
LOCUS       XP_054225047             681 aa            linear   PRI 05-AUG-2025
DEFINITION  PHD finger protein 21A isoform X5 [Homo sapiens].
ACCESSION   XP_054225047
VERSION     XP_054225047.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369072.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..681
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..681
                     /product="PHD finger protein 21A isoform X5"
                     /calculated_mol_wt=74851
     Region          <375..537
                     /region_name="TNG2"
                     /note="Chromatin remodeling protein, contains PhD zinc
                     finger [Chromatin structure and dynamics]; COG5034"
                     /db_xref="CDD:227367"
     Region          491..533
                     /region_name="PHD_PHF21A"
                     /note="PHD finger found in PHD finger protein 21A
                     (PHF21A); cd15523"
                     /db_xref="CDD:276998"
     Site            order(491,498..503,523..526,528)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:276998"
     CDS             1..681
                     /gene="PHF21A"
                     /gene_synonym="BHC80; BM-006; IDDBCS; NEDMS"
                     /coded_by="XM_054369072.1:1364..3409"
                     /db_xref="GeneID:51317"
                     /db_xref="HGNC:HGNC:24156"
                     /db_xref="MIM:608325"
ORIGIN      
        1 melqtlqeal kveiqvhqkl vaqmkqdpqn adlkkqlhel qakitalsek qkrvveqlrk
       61 nlivkqeqpd kfqiqplpqs enklqtaqqq plqqlqqqqq yhhhhaqqsa aaspnltasq
      121 ktvttasmit tktlplvlka atatmpasvv gqrptiamvt ainsqkavls tdvqntpvnl
      181 qtsskvtgpg aeavqivakn tvtlqvqatp pqpikvpqfi ppprltprpn flpqvrpkpv
      241 aqnnipiapa pppmlaapql iqrpvmltkf tpttlptsqn sihpvrvvng qtatiaktfp
      301 maqltsivia tpgtrlagpq tvqlskpsle kqtvkshtet dekqtesrti tppaapkpkr
      361 eenpqklafm vslglvthdh leeiqskrqe rkrrttanpv ysgavfeper kksavtylns
      421 tmhpgtrkrg rppkynavlg fgaltptspq sshpdspene ktettftfpa pvqpvslpsp
      481 tstdgdihed fcsvcrksgq llmcdtcsrv yhldcldppl ktipkgmwic prcqdqmlkk
      541 eeaipwpgtl aivhsyiayk aakeeekqkl lkwssdlkqe reqleqkvkq lsnsiskcme
      601 mkntilarqk emhsslekvk qlirlihgid lskpvdseat vgaisngpdc tppanaatst
      661 papspssqsc tancnqgeet k
//
LOCUS       XP_054225049             680 aa            linear   PRI 05-AUG-2025
DEFINITION  PHD finger protein 21A isoform X6 [Homo sapiens].
ACCESSION   XP_054225049
VERSION     XP_054225049.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369074.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..680
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..680
                     /product="PHD finger protein 21A isoform X6"
                     /calculated_mol_wt=74723
     Region          <111..318
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          <374..536
                     /region_name="TNG2"
                     /note="Chromatin remodeling protein, contains PhD zinc
                     finger [Chromatin structure and dynamics]; COG5034"
                     /db_xref="CDD:227367"
     Region          490..532
                     /region_name="PHD_PHF21A"
                     /note="PHD finger found in PHD finger protein 21A
                     (PHF21A); cd15523"
                     /db_xref="CDD:276998"
     Site            order(490,497..502,522..525,527)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:276998"
     CDS             1..680
                     /gene="PHF21A"
                     /gene_synonym="BHC80; BM-006; IDDBCS; NEDMS"
                     /coded_by="XM_054369074.1:763..2805"
                     /db_xref="GeneID:51317"
                     /db_xref="HGNC:HGNC:24156"
                     /db_xref="MIM:608325"
ORIGIN      
        1 melqtlqeal kveiqvhqkl vaqmkqdpqn adlkkqlhel qakitalsek qkrvveqlrk
       61 nlivkqeqpd kfqiqplpqs enklqtaqqq plqqlqqqqq yhhhhaqqsa aaspnltasq
      121 tvttasmitt ktlplvlkaa tatmpasvvg qrptiamvta insqkavlst dvqntpvnlq
      181 tsskvtgpga eavqivaknt vtlqvqatpp qpikvpqfip pprltprpnf lpqvrpkpva
      241 qnnipiapap ppmlaapqli qrpvmltkft pttlptsqns ihpvrvvngq tatiaktfpm
      301 aqltsiviat pgtrlagpqt vqlskpslek qtvkshtetd ekqtesrtit ppaapkpkre
      361 enpqklafmv slglvthdhl eeiqskrqer krrttanpvy sgavfeperk ksavtylnst
      421 mhpgtrkrgr ppkynavlgf galtptspqs shpdspenek tettftfpap vqpvslpspt
      481 stdgdihedf csvcrksgql lmcdtcsrvy hldcldpplk tipkgmwicp rcqdqmlkke
      541 eaipwpgtla ivhsyiayka akeeekqkll kwssdlkqer eqleqkvkql snsiskcmem
      601 kntilarqke mhsslekvkq lirlihgidl skpvdseatv gaisngpdct ppanaatstp
      661 apspssqsct ancnqgeetk
//
LOCUS       XP_054225050             680 aa            linear   PRI 05-AUG-2025
DEFINITION  PHD finger protein 21A isoform X7 [Homo sapiens].
ACCESSION   XP_054225050
VERSION     XP_054225050.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369075.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..680
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..680
                     /product="PHD finger protein 21A isoform X7"
                     /calculated_mol_wt=74723
     Region          <374..536
                     /region_name="TNG2"
                     /note="Chromatin remodeling protein, contains PhD zinc
                     finger [Chromatin structure and dynamics]; COG5034"
                     /db_xref="CDD:227367"
     Region          490..532
                     /region_name="PHD_PHF21A"
                     /note="PHD finger found in PHD finger protein 21A
                     (PHF21A); cd15523"
                     /db_xref="CDD:276998"
     Site            order(490,497..502,522..525,527)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:276998"
     CDS             1..680
                     /gene="PHF21A"
                     /gene_synonym="BHC80; BM-006; IDDBCS; NEDMS"
                     /coded_by="XM_054369075.1:763..2805"
                     /db_xref="GeneID:51317"
                     /db_xref="HGNC:HGNC:24156"
                     /db_xref="MIM:608325"
ORIGIN      
        1 melqtlqeal kveiqvhqkl vaqmkqdpqn adlkkqlhel qakitalsek qkrvveqlrk
       61 nlivkqeqpd kfqiqplpqs enklqtaqqq plqqlqqqqq yhhhhaqqsa aaspnltasq
      121 ktvttasmit tktlplvlka atatmpasvv gqrptiamvt ainsqkavls tdvqntpvnl
      181 qtsskvtgpg aeavqivakn tvtlvqatpp qpikvpqfip pprltprpnf lpqvrpkpva
      241 qnnipiapap ppmlaapqli qrpvmltkft pttlptsqns ihpvrvvngq tatiaktfpm
      301 aqltsiviat pgtrlagpqt vqlskpslek qtvkshtetd ekqtesrtit ppaapkpkre
      361 enpqklafmv slglvthdhl eeiqskrqer krrttanpvy sgavfeperk ksavtylnst
      421 mhpgtrkrgr ppkynavlgf galtptspqs shpdspenek tettftfpap vqpvslpspt
      481 stdgdihedf csvcrksgql lmcdtcsrvy hldcldpplk tipkgmwicp rcqdqmlkke
      541 eaipwpgtla ivhsyiayka akeeekqkll kwssdlkqer eqleqkvkql snsiskcmem
      601 kntilarqke mhsslekvkq lirlihgidl skpvdseatv gaisngpdct ppanaatstp
      661 apspssqsct ancnqgeetk
//
LOCUS       XP_054225051             680 aa            linear   PRI 05-AUG-2025
DEFINITION  PHD finger protein 21A isoform X6 [Homo sapiens].
ACCESSION   XP_054225051
VERSION     XP_054225051.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369076.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..680
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..680
                     /product="PHD finger protein 21A isoform X6"
                     /calculated_mol_wt=74723
     Region          <111..318
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          <374..536
                     /region_name="TNG2"
                     /note="Chromatin remodeling protein, contains PhD zinc
                     finger [Chromatin structure and dynamics]; COG5034"
                     /db_xref="CDD:227367"
     Region          490..532
                     /region_name="PHD_PHF21A"
                     /note="PHD finger found in PHD finger protein 21A
                     (PHF21A); cd15523"
                     /db_xref="CDD:276998"
     Site            order(490,497..502,522..525,527)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:276998"
     CDS             1..680
                     /gene="PHF21A"
                     /gene_synonym="BHC80; BM-006; IDDBCS; NEDMS"
                     /coded_by="XM_054369076.1:651..2693"
                     /db_xref="GeneID:51317"
                     /db_xref="HGNC:HGNC:24156"
                     /db_xref="MIM:608325"
ORIGIN      
        1 melqtlqeal kveiqvhqkl vaqmkqdpqn adlkkqlhel qakitalsek qkrvveqlrk
       61 nlivkqeqpd kfqiqplpqs enklqtaqqq plqqlqqqqq yhhhhaqqsa aaspnltasq
      121 tvttasmitt ktlplvlkaa tatmpasvvg qrptiamvta insqkavlst dvqntpvnlq
      181 tsskvtgpga eavqivaknt vtlqvqatpp qpikvpqfip pprltprpnf lpqvrpkpva
      241 qnnipiapap ppmlaapqli qrpvmltkft pttlptsqns ihpvrvvngq tatiaktfpm
      301 aqltsiviat pgtrlagpqt vqlskpslek qtvkshtetd ekqtesrtit ppaapkpkre
      361 enpqklafmv slglvthdhl eeiqskrqer krrttanpvy sgavfeperk ksavtylnst
      421 mhpgtrkrgr ppkynavlgf galtptspqs shpdspenek tettftfpap vqpvslpspt
      481 stdgdihedf csvcrksgql lmcdtcsrvy hldcldpplk tipkgmwicp rcqdqmlkke
      541 eaipwpgtla ivhsyiayka akeeekqkll kwssdlkqer eqleqkvkql snsiskcmem
      601 kntilarqke mhsslekvkq lirlihgidl skpvdseatv gaisngpdct ppanaatstp
      661 apspssqsct ancnqgeetk
//
LOCUS       XP_054225052             680 aa            linear   PRI 05-AUG-2025
DEFINITION  PHD finger protein 21A isoform X7 [Homo sapiens].
ACCESSION   XP_054225052
VERSION     XP_054225052.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369077.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..680
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..680
                     /product="PHD finger protein 21A isoform X7"
                     /calculated_mol_wt=74723
     Region          <374..536
                     /region_name="TNG2"
                     /note="Chromatin remodeling protein, contains PhD zinc
                     finger [Chromatin structure and dynamics]; COG5034"
                     /db_xref="CDD:227367"
     Region          490..532
                     /region_name="PHD_PHF21A"
                     /note="PHD finger found in PHD finger protein 21A
                     (PHF21A); cd15523"
                     /db_xref="CDD:276998"
     Site            order(490,497..502,522..525,527)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:276998"
     CDS             1..680
                     /gene="PHF21A"
                     /gene_synonym="BHC80; BM-006; IDDBCS; NEDMS"
                     /coded_by="XM_054369077.1:1365..3407"
                     /db_xref="GeneID:51317"
                     /db_xref="HGNC:HGNC:24156"
                     /db_xref="MIM:608325"
ORIGIN      
        1 melqtlqeal kveiqvhqkl vaqmkqdpqn adlkkqlhel qakitalsek qkrvveqlrk
       61 nlivkqeqpd kfqiqplpqs enklqtaqqq plqqlqqqqq yhhhhaqqsa aaspnltasq
      121 ktvttasmit tktlplvlka atatmpasvv gqrptiamvt ainsqkavls tdvqntpvnl
      181 qtsskvtgpg aeavqivakn tvtlvqatpp qpikvpqfip pprltprpnf lpqvrpkpva
      241 qnnipiapap ppmlaapqli qrpvmltkft pttlptsqns ihpvrvvngq tatiaktfpm
      301 aqltsiviat pgtrlagpqt vqlskpslek qtvkshtetd ekqtesrtit ppaapkpkre
      361 enpqklafmv slglvthdhl eeiqskrqer krrttanpvy sgavfeperk ksavtylnst
      421 mhpgtrkrgr ppkynavlgf galtptspqs shpdspenek tettftfpap vqpvslpspt
      481 stdgdihedf csvcrksgql lmcdtcsrvy hldcldpplk tipkgmwicp rcqdqmlkke
      541 eaipwpgtla ivhsyiayka akeeekqkll kwssdlkqer eqleqkvkql snsiskcmem
      601 kntilarqke mhsslekvkq lirlihgidl skpvdseatv gaisngpdct ppanaatstp
      661 apspssqsct ancnqgeetk
//
LOCUS       XP_054225053             680 aa            linear   PRI 05-AUG-2025
DEFINITION  PHD finger protein 21A isoform X6 [Homo sapiens].
ACCESSION   XP_054225053
VERSION     XP_054225053.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369078.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..680
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..680
                     /product="PHD finger protein 21A isoform X6"
                     /calculated_mol_wt=74723
     Region          <111..318
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          <374..536
                     /region_name="TNG2"
                     /note="Chromatin remodeling protein, contains PhD zinc
                     finger [Chromatin structure and dynamics]; COG5034"
                     /db_xref="CDD:227367"
     Region          490..532
                     /region_name="PHD_PHF21A"
                     /note="PHD finger found in PHD finger protein 21A
                     (PHF21A); cd15523"
                     /db_xref="CDD:276998"
     Site            order(490,497..502,522..525,527)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:276998"
     CDS             1..680
                     /gene="PHF21A"
                     /gene_synonym="BHC80; BM-006; IDDBCS; NEDMS"
                     /coded_by="XM_054369078.1:329..2371"
                     /db_xref="GeneID:51317"
                     /db_xref="HGNC:HGNC:24156"
                     /db_xref="MIM:608325"
ORIGIN      
        1 melqtlqeal kveiqvhqkl vaqmkqdpqn adlkkqlhel qakitalsek qkrvveqlrk
       61 nlivkqeqpd kfqiqplpqs enklqtaqqq plqqlqqqqq yhhhhaqqsa aaspnltasq
      121 tvttasmitt ktlplvlkaa tatmpasvvg qrptiamvta insqkavlst dvqntpvnlq
      181 tsskvtgpga eavqivaknt vtlqvqatpp qpikvpqfip pprltprpnf lpqvrpkpva
      241 qnnipiapap ppmlaapqli qrpvmltkft pttlptsqns ihpvrvvngq tatiaktfpm
      301 aqltsiviat pgtrlagpqt vqlskpslek qtvkshtetd ekqtesrtit ppaapkpkre
      361 enpqklafmv slglvthdhl eeiqskrqer krrttanpvy sgavfeperk ksavtylnst
      421 mhpgtrkrgr ppkynavlgf galtptspqs shpdspenek tettftfpap vqpvslpspt
      481 stdgdihedf csvcrksgql lmcdtcsrvy hldcldpplk tipkgmwicp rcqdqmlkke
      541 eaipwpgtla ivhsyiayka akeeekqkll kwssdlkqer eqleqkvkql snsiskcmem
      601 kntilarqke mhsslekvkq lirlihgidl skpvdseatv gaisngpdct ppanaatstp
      661 apspssqsct ancnqgeetk
//
LOCUS       XP_054225054             680 aa            linear   PRI 05-AUG-2025
DEFINITION  PHD finger protein 21A isoform X6 [Homo sapiens].
ACCESSION   XP_054225054
VERSION     XP_054225054.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369079.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..680
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..680
                     /product="PHD finger protein 21A isoform X6"
                     /calculated_mol_wt=74723
     Region          <111..318
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          <374..536
                     /region_name="TNG2"
                     /note="Chromatin remodeling protein, contains PhD zinc
                     finger [Chromatin structure and dynamics]; COG5034"
                     /db_xref="CDD:227367"
     Region          490..532
                     /region_name="PHD_PHF21A"
                     /note="PHD finger found in PHD finger protein 21A
                     (PHF21A); cd15523"
                     /db_xref="CDD:276998"
     Site            order(490,497..502,522..525,527)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:276998"
     CDS             1..680
                     /gene="PHF21A"
                     /gene_synonym="BHC80; BM-006; IDDBCS; NEDMS"
                     /coded_by="XM_054369079.1:1253..3295"
                     /db_xref="GeneID:51317"
                     /db_xref="HGNC:HGNC:24156"
                     /db_xref="MIM:608325"
ORIGIN      
        1 melqtlqeal kveiqvhqkl vaqmkqdpqn adlkkqlhel qakitalsek qkrvveqlrk
       61 nlivkqeqpd kfqiqplpqs enklqtaqqq plqqlqqqqq yhhhhaqqsa aaspnltasq
      121 tvttasmitt ktlplvlkaa tatmpasvvg qrptiamvta insqkavlst dvqntpvnlq
      181 tsskvtgpga eavqivaknt vtlqvqatpp qpikvpqfip pprltprpnf lpqvrpkpva
      241 qnnipiapap ppmlaapqli qrpvmltkft pttlptsqns ihpvrvvngq tatiaktfpm
      301 aqltsiviat pgtrlagpqt vqlskpslek qtvkshtetd ekqtesrtit ppaapkpkre
      361 enpqklafmv slglvthdhl eeiqskrqer krrttanpvy sgavfeperk ksavtylnst
      421 mhpgtrkrgr ppkynavlgf galtptspqs shpdspenek tettftfpap vqpvslpspt
      481 stdgdihedf csvcrksgql lmcdtcsrvy hldcldpplk tipkgmwicp rcqdqmlkke
      541 eaipwpgtla ivhsyiayka akeeekqkll kwssdlkqer eqleqkvkql snsiskcmem
      601 kntilarqke mhsslekvkq lirlihgidl skpvdseatv gaisngpdct ppanaatstp
      661 apspssqsct ancnqgeetk
//
LOCUS       XP_054225055             680 aa            linear   PRI 05-AUG-2025
DEFINITION  PHD finger protein 21A isoform X7 [Homo sapiens].
ACCESSION   XP_054225055
VERSION     XP_054225055.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369080.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..680
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..680
                     /product="PHD finger protein 21A isoform X7"
                     /calculated_mol_wt=74723
     Region          <374..536
                     /region_name="TNG2"
                     /note="Chromatin remodeling protein, contains PhD zinc
                     finger [Chromatin structure and dynamics]; COG5034"
                     /db_xref="CDD:227367"
     Region          490..532
                     /region_name="PHD_PHF21A"
                     /note="PHD finger found in PHD finger protein 21A
                     (PHF21A); cd15523"
                     /db_xref="CDD:276998"
     Site            order(490,497..502,522..525,527)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:276998"
     CDS             1..680
                     /gene="PHF21A"
                     /gene_synonym="BHC80; BM-006; IDDBCS; NEDMS"
                     /coded_by="XM_054369080.1:329..2371"
                     /db_xref="GeneID:51317"
                     /db_xref="HGNC:HGNC:24156"
                     /db_xref="MIM:608325"
ORIGIN      
        1 melqtlqeal kveiqvhqkl vaqmkqdpqn adlkkqlhel qakitalsek qkrvveqlrk
       61 nlivkqeqpd kfqiqplpqs enklqtaqqq plqqlqqqqq yhhhhaqqsa aaspnltasq
      121 ktvttasmit tktlplvlka atatmpasvv gqrptiamvt ainsqkavls tdvqntpvnl
      181 qtsskvtgpg aeavqivakn tvtlvqatpp qpikvpqfip pprltprpnf lpqvrpkpva
      241 qnnipiapap ppmlaapqli qrpvmltkft pttlptsqns ihpvrvvngq tatiaktfpm
      301 aqltsiviat pgtrlagpqt vqlskpslek qtvkshtetd ekqtesrtit ppaapkpkre
      361 enpqklafmv slglvthdhl eeiqskrqer krrttanpvy sgavfeperk ksavtylnst
      421 mhpgtrkrgr ppkynavlgf galtptspqs shpdspenek tettftfpap vqpvslpspt
      481 stdgdihedf csvcrksgql lmcdtcsrvy hldcldpplk tipkgmwicp rcqdqmlkke
      541 eaipwpgtla ivhsyiayka akeeekqkll kwssdlkqer eqleqkvkql snsiskcmem
      601 kntilarqke mhsslekvkq lirlihgidl skpvdseatv gaisngpdct ppanaatstp
      661 apspssqsct ancnqgeetk
//
LOCUS       XP_054225056             680 aa            linear   PRI 05-AUG-2025
DEFINITION  PHD finger protein 21A isoform X6 [Homo sapiens].
ACCESSION   XP_054225056
VERSION     XP_054225056.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369081.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..680
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..680
                     /product="PHD finger protein 21A isoform X6"
                     /calculated_mol_wt=74723
     Region          <111..318
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          <374..536
                     /region_name="TNG2"
                     /note="Chromatin remodeling protein, contains PhD zinc
                     finger [Chromatin structure and dynamics]; COG5034"
                     /db_xref="CDD:227367"
     Region          490..532
                     /region_name="PHD_PHF21A"
                     /note="PHD finger found in PHD finger protein 21A
                     (PHF21A); cd15523"
                     /db_xref="CDD:276998"
     Site            order(490,497..502,522..525,527)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:276998"
     CDS             1..680
                     /gene="PHF21A"
                     /gene_synonym="BHC80; BM-006; IDDBCS; NEDMS"
                     /coded_by="XM_054369081.1:441..2483"
                     /db_xref="GeneID:51317"
                     /db_xref="HGNC:HGNC:24156"
                     /db_xref="MIM:608325"
ORIGIN      
        1 melqtlqeal kveiqvhqkl vaqmkqdpqn adlkkqlhel qakitalsek qkrvveqlrk
       61 nlivkqeqpd kfqiqplpqs enklqtaqqq plqqlqqqqq yhhhhaqqsa aaspnltasq
      121 tvttasmitt ktlplvlkaa tatmpasvvg qrptiamvta insqkavlst dvqntpvnlq
      181 tsskvtgpga eavqivaknt vtlqvqatpp qpikvpqfip pprltprpnf lpqvrpkpva
      241 qnnipiapap ppmlaapqli qrpvmltkft pttlptsqns ihpvrvvngq tatiaktfpm
      301 aqltsiviat pgtrlagpqt vqlskpslek qtvkshtetd ekqtesrtit ppaapkpkre
      361 enpqklafmv slglvthdhl eeiqskrqer krrttanpvy sgavfeperk ksavtylnst
      421 mhpgtrkrgr ppkynavlgf galtptspqs shpdspenek tettftfpap vqpvslpspt
      481 stdgdihedf csvcrksgql lmcdtcsrvy hldcldpplk tipkgmwicp rcqdqmlkke
      541 eaipwpgtla ivhsyiayka akeeekqkll kwssdlkqer eqleqkvkql snsiskcmem
      601 kntilarqke mhsslekvkq lirlihgidl skpvdseatv gaisngpdct ppanaatstp
      661 apspssqsct ancnqgeetk
//
LOCUS       XP_054225057             679 aa            linear   PRI 05-AUG-2025
DEFINITION  PHD finger protein 21A isoform X8 [Homo sapiens].
ACCESSION   XP_054225057
VERSION     XP_054225057.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369082.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..679
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..679
                     /product="PHD finger protein 21A isoform X8"
                     /calculated_mol_wt=74595
     Region          <373..535
                     /region_name="TNG2"
                     /note="Chromatin remodeling protein, contains PhD zinc
                     finger [Chromatin structure and dynamics]; COG5034"
                     /db_xref="CDD:227367"
     Region          489..531
                     /region_name="PHD_PHF21A"
                     /note="PHD finger found in PHD finger protein 21A
                     (PHF21A); cd15523"
                     /db_xref="CDD:276998"
     Site            order(489,496..501,521..524,526)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:276998"
     CDS             1..679
                     /gene="PHF21A"
                     /gene_synonym="BHC80; BM-006; IDDBCS; NEDMS"
                     /coded_by="XM_054369082.1:763..2802"
                     /db_xref="GeneID:51317"
                     /db_xref="HGNC:HGNC:24156"
                     /db_xref="MIM:608325"
ORIGIN      
        1 melqtlqeal kveiqvhqkl vaqmkqdpqn adlkkqlhel qakitalsek qkrvveqlrk
       61 nlivkqeqpd kfqiqplpqs enklqtaqqq plqqlqqqqq yhhhhaqqsa aaspnltasq
      121 tvttasmitt ktlplvlkaa tatmpasvvg qrptiamvta insqkavlst dvqntpvnlq
      181 tsskvtgpga eavqivaknt vtlvqatppq pikvpqfipp prltprpnfl pqvrpkpvaq
      241 nnipiapapp pmlaapqliq rpvmltkftp ttlptsqnsi hpvrvvngqt atiaktfpma
      301 qltsiviatp gtrlagpqtv qlskpslekq tvkshtetde kqtesrtitp paapkpkree
      361 npqklafmvs lglvthdhle eiqskrqerk rrttanpvys gavfeperkk savtylnstm
      421 hpgtrkrgrp pkynavlgfg altptspqss hpdspenekt ettftfpapv qpvslpspts
      481 tdgdihedfc svcrksgqll mcdtcsrvyh ldcldpplkt ipkgmwicpr cqdqmlkkee
      541 aipwpgtlai vhsyiaykaa keeekqkllk wssdlkqere qleqkvkqls nsiskcmemk
      601 ntilarqkem hsslekvkql irlihgidls kpvdseatvg aisngpdctp panaatstpa
      661 pspssqscta ncnqgeetk
//
LOCUS       XP_054225058             679 aa            linear   PRI 05-AUG-2025
DEFINITION  PHD finger protein 21A isoform X8 [Homo sapiens].
ACCESSION   XP_054225058
VERSION     XP_054225058.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369083.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..679
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..679
                     /product="PHD finger protein 21A isoform X8"
                     /calculated_mol_wt=74595
     Region          <373..535
                     /region_name="TNG2"
                     /note="Chromatin remodeling protein, contains PhD zinc
                     finger [Chromatin structure and dynamics]; COG5034"
                     /db_xref="CDD:227367"
     Region          489..531
                     /region_name="PHD_PHF21A"
                     /note="PHD finger found in PHD finger protein 21A
                     (PHF21A); cd15523"
                     /db_xref="CDD:276998"
     Site            order(489,496..501,521..524,526)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:276998"
     CDS             1..679
                     /gene="PHF21A"
                     /gene_synonym="BHC80; BM-006; IDDBCS; NEDMS"
                     /coded_by="XM_054369083.1:651..2690"
                     /db_xref="GeneID:51317"
                     /db_xref="HGNC:HGNC:24156"
                     /db_xref="MIM:608325"
ORIGIN      
        1 melqtlqeal kveiqvhqkl vaqmkqdpqn adlkkqlhel qakitalsek qkrvveqlrk
       61 nlivkqeqpd kfqiqplpqs enklqtaqqq plqqlqqqqq yhhhhaqqsa aaspnltasq
      121 tvttasmitt ktlplvlkaa tatmpasvvg qrptiamvta insqkavlst dvqntpvnlq
      181 tsskvtgpga eavqivaknt vtlvqatppq pikvpqfipp prltprpnfl pqvrpkpvaq
      241 nnipiapapp pmlaapqliq rpvmltkftp ttlptsqnsi hpvrvvngqt atiaktfpma
      301 qltsiviatp gtrlagpqtv qlskpslekq tvkshtetde kqtesrtitp paapkpkree
      361 npqklafmvs lglvthdhle eiqskrqerk rrttanpvys gavfeperkk savtylnstm
      421 hpgtrkrgrp pkynavlgfg altptspqss hpdspenekt ettftfpapv qpvslpspts
      481 tdgdihedfc svcrksgqll mcdtcsrvyh ldcldpplkt ipkgmwicpr cqdqmlkkee
      541 aipwpgtlai vhsyiaykaa keeekqkllk wssdlkqere qleqkvkqls nsiskcmemk
      601 ntilarqkem hsslekvkql irlihgidls kpvdseatvg aisngpdctp panaatstpa
      661 pspssqscta ncnqgeetk
//
LOCUS       XP_054225059             649 aa            linear   PRI 05-AUG-2025
DEFINITION  PHD finger protein 21A isoform X9 [Homo sapiens].
ACCESSION   XP_054225059
VERSION     XP_054225059.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369084.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..649
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..649
                     /product="PHD finger protein 21A isoform X9"
                     /calculated_mol_wt=71583
     Region          <112..319
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          <375..537
                     /region_name="TNG2"
                     /note="Chromatin remodeling protein, contains PhD zinc
                     finger [Chromatin structure and dynamics]; COG5034"
                     /db_xref="CDD:227367"
     Region          491..533
                     /region_name="PHD_PHF21A"
                     /note="PHD finger found in PHD finger protein 21A
                     (PHF21A); cd15523"
                     /db_xref="CDD:276998"
     Site            order(491,498..503,523..526,528)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:276998"
     CDS             1..649
                     /gene="PHF21A"
                     /gene_synonym="BHC80; BM-006; IDDBCS; NEDMS"
                     /coded_by="XM_054369084.1:763..2712"
                     /db_xref="GeneID:51317"
                     /db_xref="HGNC:HGNC:24156"
                     /db_xref="MIM:608325"
ORIGIN      
        1 melqtlqeal kveiqvhqkl vaqmkqdpqn adlkkqlhel qakitalsek qkrvveqlrk
       61 nlivkqeqpd kfqiqplpqs enklqtaqqq plqqlqqqqq yhhhhaqqsa aaspnltasq
      121 ktvttasmit tktlplvlka atatmpasvv gqrptiamvt ainsqkavls tdvqntpvnl
      181 qtsskvtgpg aeavqivakn tvtlqvqatp pqpikvpqfi ppprltprpn flpqvrpkpv
      241 aqnnipiapa pppmlaapql iqrpvmltkf tpttlptsqn sihpvrvvng qtatiaktfp
      301 maqltsivia tpgtrlagpq tvqlskpsle kqtvkshtet dekqtesrti tppaapkpkr
      361 eenpqklafm vslglvthdh leeiqskrqe rkrrttanpv ysgavfeper kksavtylns
      421 tmhpgtrkrg rppkynavlg fgaltptspq sshpdspene ktettftfpa pvqpvslpsp
      481 tstdgdihed fcsvcrksgq llmcdtcsrv yhldcldppl ktipkgmwic prcqdqmlkk
      541 eeaipwpgtl aivhsyiayk aakeeekqkl lkwssdlkqe reqleqkvkq lsnsisceea
      601 gfletsigkm hgneehhpgp aegdaqlpge gktadsphpr hrplqtcrl
//
LOCUS       XP_054225060             649 aa            linear   PRI 05-AUG-2025
DEFINITION  PHD finger protein 21A isoform X9 [Homo sapiens].
ACCESSION   XP_054225060
VERSION     XP_054225060.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369085.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..649
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..649
                     /product="PHD finger protein 21A isoform X9"
                     /calculated_mol_wt=71583
     Region          <112..319
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          <375..537
                     /region_name="TNG2"
                     /note="Chromatin remodeling protein, contains PhD zinc
                     finger [Chromatin structure and dynamics]; COG5034"
                     /db_xref="CDD:227367"
     Region          491..533
                     /region_name="PHD_PHF21A"
                     /note="PHD finger found in PHD finger protein 21A
                     (PHF21A); cd15523"
                     /db_xref="CDD:276998"
     Site            order(491,498..503,523..526,528)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:276998"
     CDS             1..649
                     /gene="PHF21A"
                     /gene_synonym="BHC80; BM-006; IDDBCS; NEDMS"
                     /coded_by="XM_054369085.1:441..2390"
                     /db_xref="GeneID:51317"
                     /db_xref="HGNC:HGNC:24156"
                     /db_xref="MIM:608325"
ORIGIN      
        1 melqtlqeal kveiqvhqkl vaqmkqdpqn adlkkqlhel qakitalsek qkrvveqlrk
       61 nlivkqeqpd kfqiqplpqs enklqtaqqq plqqlqqqqq yhhhhaqqsa aaspnltasq
      121 ktvttasmit tktlplvlka atatmpasvv gqrptiamvt ainsqkavls tdvqntpvnl
      181 qtsskvtgpg aeavqivakn tvtlqvqatp pqpikvpqfi ppprltprpn flpqvrpkpv
      241 aqnnipiapa pppmlaapql iqrpvmltkf tpttlptsqn sihpvrvvng qtatiaktfp
      301 maqltsivia tpgtrlagpq tvqlskpsle kqtvkshtet dekqtesrti tppaapkpkr
      361 eenpqklafm vslglvthdh leeiqskrqe rkrrttanpv ysgavfeper kksavtylns
      421 tmhpgtrkrg rppkynavlg fgaltptspq sshpdspene ktettftfpa pvqpvslpsp
      481 tstdgdihed fcsvcrksgq llmcdtcsrv yhldcldppl ktipkgmwic prcqdqmlkk
      541 eeaipwpgtl aivhsyiayk aakeeekqkl lkwssdlkqe reqleqkvkq lsnsisceea
      601 gfletsigkm hgneehhpgp aegdaqlpge gktadsphpr hrplqtcrl
//
LOCUS       XP_054225061             649 aa            linear   PRI 05-AUG-2025
DEFINITION  PHD finger protein 21A isoform X9 [Homo sapiens].
ACCESSION   XP_054225061
VERSION     XP_054225061.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369086.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..649
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..649
                     /product="PHD finger protein 21A isoform X9"
                     /calculated_mol_wt=71583
     Region          <112..319
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          <375..537
                     /region_name="TNG2"
                     /note="Chromatin remodeling protein, contains PhD zinc
                     finger [Chromatin structure and dynamics]; COG5034"
                     /db_xref="CDD:227367"
     Region          491..533
                     /region_name="PHD_PHF21A"
                     /note="PHD finger found in PHD finger protein 21A
                     (PHF21A); cd15523"
                     /db_xref="CDD:276998"
     Site            order(491,498..503,523..526,528)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:276998"
     CDS             1..649
                     /gene="PHF21A"
                     /gene_synonym="BHC80; BM-006; IDDBCS; NEDMS"
                     /coded_by="XM_054369086.1:651..2600"
                     /db_xref="GeneID:51317"
                     /db_xref="HGNC:HGNC:24156"
                     /db_xref="MIM:608325"
ORIGIN      
        1 melqtlqeal kveiqvhqkl vaqmkqdpqn adlkkqlhel qakitalsek qkrvveqlrk
       61 nlivkqeqpd kfqiqplpqs enklqtaqqq plqqlqqqqq yhhhhaqqsa aaspnltasq
      121 ktvttasmit tktlplvlka atatmpasvv gqrptiamvt ainsqkavls tdvqntpvnl
      181 qtsskvtgpg aeavqivakn tvtlqvqatp pqpikvpqfi ppprltprpn flpqvrpkpv
      241 aqnnipiapa pppmlaapql iqrpvmltkf tpttlptsqn sihpvrvvng qtatiaktfp
      301 maqltsivia tpgtrlagpq tvqlskpsle kqtvkshtet dekqtesrti tppaapkpkr
      361 eenpqklafm vslglvthdh leeiqskrqe rkrrttanpv ysgavfeper kksavtylns
      421 tmhpgtrkrg rppkynavlg fgaltptspq sshpdspene ktettftfpa pvqpvslpsp
      481 tstdgdihed fcsvcrksgq llmcdtcsrv yhldcldppl ktipkgmwic prcqdqmlkk
      541 eeaipwpgtl aivhsyiayk aakeeekqkl lkwssdlkqe reqleqkvkq lsnsisceea
      601 gfletsigkm hgneehhpgp aegdaqlpge gktadsphpr hrplqtcrl
//
LOCUS       XP_054225062             641 aa            linear   PRI 05-AUG-2025
DEFINITION  PHD finger protein 21A isoform X10 [Homo sapiens].
ACCESSION   XP_054225062
VERSION     XP_054225062.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369087.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..641
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..641
                     /product="PHD finger protein 21A isoform X10"
                     /calculated_mol_wt=70929
     Region          <119..326
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          451..493
                     /region_name="PHD_PHF21A"
                     /note="PHD finger found in PHD finger protein 21A
                     (PHF21A); cd15523"
                     /db_xref="CDD:276998"
     Site            order(451,458..463,483..486,488)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:276998"
     CDS             1..641
                     /gene="PHF21A"
                     /gene_synonym="BHC80; BM-006; IDDBCS; NEDMS"
                     /coded_by="XM_054369087.1:380..2305"
                     /db_xref="GeneID:51317"
                     /db_xref="HGNC:HGNC:24156"
                     /db_xref="MIM:608325"
ORIGIN      
        1 melqtlqeal kveiqvhqkl vaqmkqdpqi fflsnqnadl kkqlhelqak italsekqkr
       61 vveqlrknli vkqeqpdkfq iqplpqsenk lqtaqqqplq qlqqqqqyhh hhaqqsaaas
      121 pnltasqktv ttasmittkt lplvlkaata tmpasvvgqr ptiamvtain sqkavlstdv
      181 qntpvnlqts skvtgpgaea vqivakntvt lqvqatppqp ikvpqfippp rltprpnflp
      241 qvrpkpvaqn nipiapappp mlaapqliqr pvmltkftpt tlptsqnsih pvrvvngqta
      301 tiaktfpmaq ltsiviatpg trlagpqtvq lskpslekqt vkshtetdek qtesrtitpp
      361 aapkpkreen pqklafmvsl glvthdhlee iqskrqerkr rttanpvysg avfeperkks
      421 avtylnstmh pgtrkranee hwpkgdihed fcsvcrksgq llmcdtcsrv yhldcldppl
      481 ktipkgmwic prcqdqmlkk eeaipwpgtl aivhsyiayk aakeeekqkl lkwssdlkqe
      541 reqleqkvkq lsnsiskcme mkntilarqk emhsslekvk qlirlihgid lskpvdseat
      601 vgaisngpdc tppanaatst papspssqsc tancnqgeet k
//
LOCUS       XP_054225063             640 aa            linear   PRI 05-AUG-2025
DEFINITION  PHD finger protein 21A isoform X11 [Homo sapiens].
ACCESSION   XP_054225063
VERSION     XP_054225063.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369088.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..640
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..640
                     /product="PHD finger protein 21A isoform X11"
                     /calculated_mol_wt=70801
     Region          <118..325
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          450..492
                     /region_name="PHD_PHF21A"
                     /note="PHD finger found in PHD finger protein 21A
                     (PHF21A); cd15523"
                     /db_xref="CDD:276998"
     Site            order(450,457..462,482..485,487)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:276998"
     CDS             1..640
                     /gene="PHF21A"
                     /gene_synonym="BHC80; BM-006; IDDBCS; NEDMS"
                     /coded_by="XM_054369088.1:380..2302"
                     /db_xref="GeneID:51317"
                     /db_xref="HGNC:HGNC:24156"
                     /db_xref="MIM:608325"
ORIGIN      
        1 melqtlqeal kveiqvhqkl vaqmkqdpqi fflsnqnadl kkqlhelqak italsekqkr
       61 vveqlrknli vkqeqpdkfq iqplpqsenk lqtaqqqplq qlqqqqqyhh hhaqqsaaas
      121 pnltasqtvt tasmittktl plvlkaatat mpasvvgqrp tiamvtains qkavlstdvq
      181 ntpvnlqtss kvtgpgaeav qivakntvtl qvqatppqpi kvpqfipppr ltprpnflpq
      241 vrpkpvaqnn ipiapapppm laapqliqrp vmltkftptt lptsqnsihp vrvvngqtat
      301 iaktfpmaql tsiviatpgt rlagpqtvql skpslekqtv kshtetdekq tesrtitppa
      361 apkpkreenp qklafmvslg lvthdhleei qskrqerkrr ttanpvysga vfeperkksa
      421 vtylnstmhp gtrkraneeh wpkgdihedf csvcrksgql lmcdtcsrvy hldcldpplk
      481 tipkgmwicp rcqdqmlkke eaipwpgtla ivhsyiayka akeeekqkll kwssdlkqer
      541 eqleqkvkql snsiskcmem kntilarqke mhsslekvkq lirlihgidl skpvdseatv
      601 gaisngpdct ppanaatstp apspssqsct ancnqgeetk
//
LOCUS       XP_054225064             640 aa            linear   PRI 05-AUG-2025
DEFINITION  PHD finger protein 21A isoform X12 [Homo sapiens].
ACCESSION   XP_054225064
VERSION     XP_054225064.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369089.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..640
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..640
                     /product="PHD finger protein 21A isoform X12"
                     /calculated_mol_wt=70801
     Region          <83..325
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          450..492
                     /region_name="PHD_PHF21A"
                     /note="PHD finger found in PHD finger protein 21A
                     (PHF21A); cd15523"
                     /db_xref="CDD:276998"
     Site            order(450,457..462,482..485,487)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:276998"
     CDS             1..640
                     /gene="PHF21A"
                     /gene_synonym="BHC80; BM-006; IDDBCS; NEDMS"
                     /coded_by="XM_054369089.1:651..2573"
                     /db_xref="GeneID:51317"
                     /db_xref="HGNC:HGNC:24156"
                     /db_xref="MIM:608325"
ORIGIN      
        1 melqtlqeal kveiqvhqkl vaqmkqdpqi fflsnqnadl kkqlhelqak italsekqkr
       61 vveqlrknli vkqeqpdkfq iqplpqsenk lqtaqqqplq qlqqqqqyhh hhaqqsaaas
      121 pnltasqktv ttasmittkt lplvlkaata tmpasvvgqr ptiamvtain sqkavlstdv
      181 qntpvnlqts skvtgpgaea vqivakntvt lvqatppqpi kvpqfipppr ltprpnflpq
      241 vrpkpvaqnn ipiapapppm laapqliqrp vmltkftptt lptsqnsihp vrvvngqtat
      301 iaktfpmaql tsiviatpgt rlagpqtvql skpslekqtv kshtetdekq tesrtitppa
      361 apkpkreenp qklafmvslg lvthdhleei qskrqerkrr ttanpvysga vfeperkksa
      421 vtylnstmhp gtrkraneeh wpkgdihedf csvcrksgql lmcdtcsrvy hldcldpplk
      481 tipkgmwicp rcqdqmlkke eaipwpgtla ivhsyiayka akeeekqkll kwssdlkqer
      541 eqleqkvkql snsiskcmem kntilarqke mhsslekvkq lirlihgidl skpvdseatv
      601 gaisngpdct ppanaatstp apspssqsct ancnqgeetk
//
LOCUS       XP_054225065             636 aa            linear   PRI 05-AUG-2025
DEFINITION  PHD finger protein 21A isoform X13 [Homo sapiens].
ACCESSION   XP_054225065
VERSION     XP_054225065.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369090.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..636
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..636
                     /product="PHD finger protein 21A isoform X13"
                     /calculated_mol_wt=69762
     CDS             1..636
                     /gene="PHF21A"
                     /gene_synonym="BHC80; BM-006; IDDBCS; NEDMS"
                     /coded_by="XM_054369090.1:380..2290"
                     /db_xref="GeneID:51317"
                     /db_xref="HGNC:HGNC:24156"
                     /db_xref="MIM:608325"
ORIGIN      
        1 melqtlqeal kveiqvhqkl vaqmkqdpqi fflsnqnadl kkqlhelqak italsekqkr
       61 vveqlrknli vkqeqpdkfq iqplpqsenk lqtaqqqplq qlqqqqqyhh hhaqqsaaas
      121 pnltasqktv ttasmittkt lplvlkaata tmpasvvgqr ptiamvtain sqkavlstdv
      181 qntpvnlqts skvtgpgaea vqivakntvt lqvqatppqp ikvpqfippp rltprpnflp
      241 qvrpkpvaqn nipiapappp mlaapqliqr pvmltkftpt tlptsqnsih pvrvvngqta
      301 tiaktfpmaq ltsiviatpg trlagpqtvq lskpslekqt vkshtetdek qtesrtitpp
      361 aapkpkreen pqklafmvsl glvthdhlee iqskrqerkr rttanpvysg avfeperkks
      421 avtylnstmh pgtrkrgrpp kynavlgfga ltptspqssh pdspenekte ttftfpapvq
      481 pvslpsptst dmlkkeeaip wpgtlaivhs yiaykaakee ekqkllkwss dlkqereqle
      541 qkvkqlsnsi skcmemknti larqkemhss lekvkqlirl ihgidlskpv dseatvgais
      601 ngpdctppan aatstpapsp ssqsctancn qgeetk
//
LOCUS       XP_054225066             634 aa            linear   PRI 05-AUG-2025
DEFINITION  PHD finger protein 21A isoform X14 [Homo sapiens].
ACCESSION   XP_054225066
VERSION     XP_054225066.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369091.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..634
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..634
                     /product="PHD finger protein 21A isoform X14"
                     /calculated_mol_wt=70079
     Region          <112..319
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          444..486
                     /region_name="PHD_PHF21A"
                     /note="PHD finger found in PHD finger protein 21A
                     (PHF21A); cd15523"
                     /db_xref="CDD:276998"
     Site            order(444,451..456,476..479,481)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:276998"
     CDS             1..634
                     /gene="PHF21A"
                     /gene_synonym="BHC80; BM-006; IDDBCS; NEDMS"
                     /coded_by="XM_054369091.1:763..2667"
                     /db_xref="GeneID:51317"
                     /db_xref="HGNC:HGNC:24156"
                     /db_xref="MIM:608325"
ORIGIN      
        1 melqtlqeal kveiqvhqkl vaqmkqdpqn adlkkqlhel qakitalsek qkrvveqlrk
       61 nlivkqeqpd kfqiqplpqs enklqtaqqq plqqlqqqqq yhhhhaqqsa aaspnltasq
      121 ktvttasmit tktlplvlka atatmpasvv gqrptiamvt ainsqkavls tdvqntpvnl
      181 qtsskvtgpg aeavqivakn tvtlqvqatp pqpikvpqfi ppprltprpn flpqvrpkpv
      241 aqnnipiapa pppmlaapql iqrpvmltkf tpttlptsqn sihpvrvvng qtatiaktfp
      301 maqltsivia tpgtrlagpq tvqlskpsle kqtvkshtet dekqtesrti tppaapkpkr
      361 eenpqklafm vslglvthdh leeiqskrqe rkrrttanpv ysgavfeper kksavtylns
      421 tmhpgtrkra neehwpkgdi hedfcsvcrk sgqllmcdtc srvyhldcld pplktipkgm
      481 wicprcqdqm lkkeeaipwp gtlaivhsyi aykaakeeek qkllkwssdl kqereqleqk
      541 vkqlsnsisk cmemkntila rqkemhssle kvkqlirlih gidlskpvds eatvgaisng
      601 pdctppanaa tstpapspss qsctancnqg eetk
//
LOCUS       XP_054225067             634 aa            linear   PRI 05-AUG-2025
DEFINITION  PHD finger protein 21A isoform X14 [Homo sapiens].
ACCESSION   XP_054225067
VERSION     XP_054225067.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369092.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..634
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..634
                     /product="PHD finger protein 21A isoform X14"
                     /calculated_mol_wt=70079
     Region          <112..319
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          444..486
                     /region_name="PHD_PHF21A"
                     /note="PHD finger found in PHD finger protein 21A
                     (PHF21A); cd15523"
                     /db_xref="CDD:276998"
     Site            order(444,451..456,476..479,481)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:276998"
     CDS             1..634
                     /gene="PHF21A"
                     /gene_synonym="BHC80; BM-006; IDDBCS; NEDMS"
                     /coded_by="XM_054369092.1:441..2345"
                     /db_xref="GeneID:51317"
                     /db_xref="HGNC:HGNC:24156"
                     /db_xref="MIM:608325"
ORIGIN      
        1 melqtlqeal kveiqvhqkl vaqmkqdpqn adlkkqlhel qakitalsek qkrvveqlrk
       61 nlivkqeqpd kfqiqplpqs enklqtaqqq plqqlqqqqq yhhhhaqqsa aaspnltasq
      121 ktvttasmit tktlplvlka atatmpasvv gqrptiamvt ainsqkavls tdvqntpvnl
      181 qtsskvtgpg aeavqivakn tvtlqvqatp pqpikvpqfi ppprltprpn flpqvrpkpv
      241 aqnnipiapa pppmlaapql iqrpvmltkf tpttlptsqn sihpvrvvng qtatiaktfp
      301 maqltsivia tpgtrlagpq tvqlskpsle kqtvkshtet dekqtesrti tppaapkpkr
      361 eenpqklafm vslglvthdh leeiqskrqe rkrrttanpv ysgavfeper kksavtylns
      421 tmhpgtrkra neehwpkgdi hedfcsvcrk sgqllmcdtc srvyhldcld pplktipkgm
      481 wicprcqdqm lkkeeaipwp gtlaivhsyi aykaakeeek qkllkwssdl kqereqleqk
      541 vkqlsnsisk cmemkntila rqkemhssle kvkqlirlih gidlskpvds eatvgaisng
      601 pdctppanaa tstpapspss qsctancnqg eetk
//
LOCUS       XP_054225068             634 aa            linear   PRI 05-AUG-2025
DEFINITION  PHD finger protein 21A isoform X14 [Homo sapiens].
ACCESSION   XP_054225068
VERSION     XP_054225068.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369093.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..634
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..634
                     /product="PHD finger protein 21A isoform X14"
                     /calculated_mol_wt=70079
     Region          <112..319
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          444..486
                     /region_name="PHD_PHF21A"
                     /note="PHD finger found in PHD finger protein 21A
                     (PHF21A); cd15523"
                     /db_xref="CDD:276998"
     Site            order(444,451..456,476..479,481)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:276998"
     CDS             1..634
                     /gene="PHF21A"
                     /gene_synonym="BHC80; BM-006; IDDBCS; NEDMS"
                     /coded_by="XM_054369093.1:329..2233"
                     /db_xref="GeneID:51317"
                     /db_xref="HGNC:HGNC:24156"
                     /db_xref="MIM:608325"
ORIGIN      
        1 melqtlqeal kveiqvhqkl vaqmkqdpqn adlkkqlhel qakitalsek qkrvveqlrk
       61 nlivkqeqpd kfqiqplpqs enklqtaqqq plqqlqqqqq yhhhhaqqsa aaspnltasq
      121 ktvttasmit tktlplvlka atatmpasvv gqrptiamvt ainsqkavls tdvqntpvnl
      181 qtsskvtgpg aeavqivakn tvtlqvqatp pqpikvpqfi ppprltprpn flpqvrpkpv
      241 aqnnipiapa pppmlaapql iqrpvmltkf tpttlptsqn sihpvrvvng qtatiaktfp
      301 maqltsivia tpgtrlagpq tvqlskpsle kqtvkshtet dekqtesrti tppaapkpkr
      361 eenpqklafm vslglvthdh leeiqskrqe rkrrttanpv ysgavfeper kksavtylns
      421 tmhpgtrkra neehwpkgdi hedfcsvcrk sgqllmcdtc srvyhldcld pplktipkgm
      481 wicprcqdqm lkkeeaipwp gtlaivhsyi aykaakeeek qkllkwssdl kqereqleqk
      541 vkqlsnsisk cmemkntila rqkemhssle kvkqlirlih gidlskpvds eatvgaisng
      601 pdctppanaa tstpapspss qsctancnqg eetk
//
LOCUS       XP_054225069             633 aa            linear   PRI 05-AUG-2025
DEFINITION  PHD finger protein 21A isoform X15 [Homo sapiens].
ACCESSION   XP_054225069
VERSION     XP_054225069.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369094.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..633
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..633
                     /product="PHD finger protein 21A isoform X15"
                     /calculated_mol_wt=69951
     Region          <111..318
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          443..485
                     /region_name="PHD_PHF21A"
                     /note="PHD finger found in PHD finger protein 21A
                     (PHF21A); cd15523"
                     /db_xref="CDD:276998"
     Site            order(443,450..455,475..478,480)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:276998"
     CDS             1..633
                     /gene="PHF21A"
                     /gene_synonym="BHC80; BM-006; IDDBCS; NEDMS"
                     /coded_by="XM_054369094.1:331..2232"
                     /db_xref="GeneID:51317"
                     /db_xref="HGNC:HGNC:24156"
                     /db_xref="MIM:608325"
ORIGIN      
        1 melqtlqeal kveiqvhqkl vaqmkqdpqn adlkkqlhel qakitalsek qkrvveqlrk
       61 nlivkqeqpd kfqiqplpqs enklqtaqqq plqqlqqqqq yhhhhaqqsa aaspnltasq
      121 tvttasmitt ktlplvlkaa tatmpasvvg qrptiamvta insqkavlst dvqntpvnlq
      181 tsskvtgpga eavqivaknt vtlqvqatpp qpikvpqfip pprltprpnf lpqvrpkpva
      241 qnnipiapap ppmlaapqli qrpvmltkft pttlptsqns ihpvrvvngq tatiaktfpm
      301 aqltsiviat pgtrlagpqt vqlskpslek qtvkshtetd ekqtesrtit ppaapkpkre
      361 enpqklafmv slglvthdhl eeiqskrqer krrttanpvy sgavfeperk ksavtylnst
      421 mhpgtrkran eehwpkgdih edfcsvcrks gqllmcdtcs rvyhldcldp plktipkgmw
      481 icprcqdqml kkeeaipwpg tlaivhsyia ykaakeeekq kllkwssdlk qereqleqkv
      541 kqlsnsiskc memkntilar qkemhsslek vkqlirlihg idlskpvdse atvgaisngp
      601 dctppanaat stpapspssq sctancnqge etk
//
LOCUS       XP_054225070             632 aa            linear   PRI 05-AUG-2025
DEFINITION  PHD finger protein 21A isoform X16 [Homo sapiens].
ACCESSION   XP_054225070
VERSION     XP_054225070.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369095.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..632
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..632
                     /product="PHD finger protein 21A isoform X16"
                     /calculated_mol_wt=69823
     Region          <111..317
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          442..484
                     /region_name="PHD_PHF21A"
                     /note="PHD finger found in PHD finger protein 21A
                     (PHF21A); cd15523"
                     /db_xref="CDD:276998"
     Site            order(442,449..454,474..477,479)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:276998"
     CDS             1..632
                     /gene="PHF21A"
                     /gene_synonym="BHC80; BM-006; IDDBCS; NEDMS"
                     /coded_by="XM_054369095.1:380..2278"
                     /db_xref="GeneID:51317"
                     /db_xref="HGNC:HGNC:24156"
                     /db_xref="MIM:608325"
ORIGIN      
        1 melqtlqeal kveiqvhqkl vaqmkqdpqn adlkkqlhel qakitalsek qkrvveqlrk
       61 nlivkqeqpd kfqiqplpqs enklqtaqqq plqqlqqqqq yhhhhaqqsa aaspnltasq
      121 tvttasmitt ktlplvlkaa tatmpasvvg qrptiamvta insqkavlst dvqntpvnlq
      181 tsskvtgpga eavqivaknt vtlvqatppq pikvpqfipp prltprpnfl pqvrpkpvaq
      241 nnipiapapp pmlaapqliq rpvmltkftp ttlptsqnsi hpvrvvngqt atiaktfpma
      301 qltsiviatp gtrlagpqtv qlskpslekq tvkshtetde kqtesrtitp paapkpkree
      361 npqklafmvs lglvthdhle eiqskrqerk rrttanpvys gavfeperkk savtylnstm
      421 hpgtrkrane ehwpkgdihe dfcsvcrksg qllmcdtcsr vyhldcldpp lktipkgmwi
      481 cprcqdqmlk keeaipwpgt laivhsyiay kaakeeekqk llkwssdlkq ereqleqkvk
      541 qlsnsiskcm emkntilarq kemhsslekv kqlirlihgi dlskpvdsea tvgaisngpd
      601 ctppanaats tpapspssqs ctancnqgee tk
//
LOCUS       XP_054225071             629 aa            linear   PRI 05-AUG-2025
DEFINITION  PHD finger protein 21A isoform X17 [Homo sapiens].
ACCESSION   XP_054225071
VERSION     XP_054225071.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369096.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..629
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..629
                     /product="PHD finger protein 21A isoform X17"
                     /calculated_mol_wt=68912
     CDS             1..629
                     /gene="PHF21A"
                     /gene_synonym="BHC80; BM-006; IDDBCS; NEDMS"
                     /coded_by="XM_054369096.1:763..2652"
                     /db_xref="GeneID:51317"
                     /db_xref="HGNC:HGNC:24156"
                     /db_xref="MIM:608325"
ORIGIN      
        1 melqtlqeal kveiqvhqkl vaqmkqdpqn adlkkqlhel qakitalsek qkrvveqlrk
       61 nlivkqeqpd kfqiqplpqs enklqtaqqq plqqlqqqqq yhhhhaqqsa aaspnltasq
      121 ktvttasmit tktlplvlka atatmpasvv gqrptiamvt ainsqkavls tdvqntpvnl
      181 qtsskvtgpg aeavqivakn tvtlqvqatp pqpikvpqfi ppprltprpn flpqvrpkpv
      241 aqnnipiapa pppmlaapql iqrpvmltkf tpttlptsqn sihpvrvvng qtatiaktfp
      301 maqltsivia tpgtrlagpq tvqlskpsle kqtvkshtet dekqtesrti tppaapkpkr
      361 eenpqklafm vslglvthdh leeiqskrqe rkrrttanpv ysgavfeper kksavtylns
      421 tmhpgtrkrg rppkynavlg fgaltptspq sshpdspene ktettftfpa pvqpvslpsp
      481 tstdmlkkee aipwpgtlai vhsyiaykaa keeekqkllk wssdlkqere qleqkvkqls
      541 nsiskcmemk ntilarqkem hsslekvkql irlihgidls kpvdseatvg aisngpdctp
      601 panaatstpa pspssqscta ncnqgeetk
//
LOCUS       XP_054225072             629 aa            linear   PRI 05-AUG-2025
DEFINITION  PHD finger protein 21A isoform X17 [Homo sapiens].
ACCESSION   XP_054225072
VERSION     XP_054225072.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369097.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..629
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..629
                     /product="PHD finger protein 21A isoform X17"
                     /calculated_mol_wt=68912
     CDS             1..629
                     /gene="PHF21A"
                     /gene_synonym="BHC80; BM-006; IDDBCS; NEDMS"
                     /coded_by="XM_054369097.1:651..2540"
                     /db_xref="GeneID:51317"
                     /db_xref="HGNC:HGNC:24156"
                     /db_xref="MIM:608325"
ORIGIN      
        1 melqtlqeal kveiqvhqkl vaqmkqdpqn adlkkqlhel qakitalsek qkrvveqlrk
       61 nlivkqeqpd kfqiqplpqs enklqtaqqq plqqlqqqqq yhhhhaqqsa aaspnltasq
      121 ktvttasmit tktlplvlka atatmpasvv gqrptiamvt ainsqkavls tdvqntpvnl
      181 qtsskvtgpg aeavqivakn tvtlqvqatp pqpikvpqfi ppprltprpn flpqvrpkpv
      241 aqnnipiapa pppmlaapql iqrpvmltkf tpttlptsqn sihpvrvvng qtatiaktfp
      301 maqltsivia tpgtrlagpq tvqlskpsle kqtvkshtet dekqtesrti tppaapkpkr
      361 eenpqklafm vslglvthdh leeiqskrqe rkrrttanpv ysgavfeper kksavtylns
      421 tmhpgtrkrg rppkynavlg fgaltptspq sshpdspene ktettftfpa pvqpvslpsp
      481 tstdmlkkee aipwpgtlai vhsyiaykaa keeekqkllk wssdlkqere qleqkvkqls
      541 nsiskcmemk ntilarqkem hsslekvkql irlihgidls kpvdseatvg aisngpdctp
      601 panaatstpa pspssqscta ncnqgeetk
//
LOCUS       XP_054225073             628 aa            linear   PRI 05-AUG-2025
DEFINITION  PHD finger protein 21A isoform X18 [Homo sapiens].
ACCESSION   XP_054225073
VERSION     XP_054225073.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369098.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..628
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..628
                     /product="PHD finger protein 21A isoform X18"
                     /calculated_mol_wt=68784
     CDS             1..628
                     /gene="PHF21A"
                     /gene_synonym="BHC80; BM-006; IDDBCS; NEDMS"
                     /coded_by="XM_054369098.1:763..2649"
                     /db_xref="GeneID:51317"
                     /db_xref="HGNC:HGNC:24156"
                     /db_xref="MIM:608325"
ORIGIN      
        1 melqtlqeal kveiqvhqkl vaqmkqdpqn adlkkqlhel qakitalsek qkrvveqlrk
       61 nlivkqeqpd kfqiqplpqs enklqtaqqq plqqlqqqqq yhhhhaqqsa aaspnltasq
      121 ktvttasmit tktlplvlka atatmpasvv gqrptiamvt ainsqkavls tdvqntpvnl
      181 qtsskvtgpg aeavqivakn tvtlvqatpp qpikvpqfip pprltprpnf lpqvrpkpva
      241 qnnipiapap ppmlaapqli qrpvmltkft pttlptsqns ihpvrvvngq tatiaktfpm
      301 aqltsiviat pgtrlagpqt vqlskpslek qtvkshtetd ekqtesrtit ppaapkpkre
      361 enpqklafmv slglvthdhl eeiqskrqer krrttanpvy sgavfeperk ksavtylnst
      421 mhpgtrkrgr ppkynavlgf galtptspqs shpdspenek tettftfpap vqpvslpspt
      481 stdmlkkeea ipwpgtlaiv hsyiaykaak eeekqkllkw ssdlkqereq leqkvkqlsn
      541 siskcmemkn tilarqkemh sslekvkqli rlihgidlsk pvdseatvga isngpdctpp
      601 anaatstpap spssqsctan cnqgeetk
//
LOCUS       XP_054225074             628 aa            linear   PRI 05-AUG-2025
DEFINITION  PHD finger protein 21A isoform X19 [Homo sapiens].
ACCESSION   XP_054225074
VERSION     XP_054225074.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369099.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..628
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..628
                     /product="PHD finger protein 21A isoform X19"
                     /calculated_mol_wt=68784
     CDS             1..628
                     /gene="PHF21A"
                     /gene_synonym="BHC80; BM-006; IDDBCS; NEDMS"
                     /coded_by="XM_054369099.1:651..2537"
                     /db_xref="GeneID:51317"
                     /db_xref="HGNC:HGNC:24156"
                     /db_xref="MIM:608325"
ORIGIN      
        1 melqtlqeal kveiqvhqkl vaqmkqdpqn adlkkqlhel qakitalsek qkrvveqlrk
       61 nlivkqeqpd kfqiqplpqs enklqtaqqq plqqlqqqqq yhhhhaqqsa aaspnltasq
      121 tvttasmitt ktlplvlkaa tatmpasvvg qrptiamvta insqkavlst dvqntpvnlq
      181 tsskvtgpga eavqivaknt vtlqvqatpp qpikvpqfip pprltprpnf lpqvrpkpva
      241 qnnipiapap ppmlaapqli qrpvmltkft pttlptsqns ihpvrvvngq tatiaktfpm
      301 aqltsiviat pgtrlagpqt vqlskpslek qtvkshtetd ekqtesrtit ppaapkpkre
      361 enpqklafmv slglvthdhl eeiqskrqer krrttanpvy sgavfeperk ksavtylnst
      421 mhpgtrkrgr ppkynavlgf galtptspqs shpdspenek tettftfpap vqpvslpspt
      481 stdmlkkeea ipwpgtlaiv hsyiaykaak eeekqkllkw ssdlkqereq leqkvkqlsn
      541 siskcmemkn tilarqkemh sslekvkqli rlihgidlsk pvdseatvga isngpdctpp
      601 anaatstpap spssqsctan cnqgeetk
//
LOCUS       XP_054225076             628 aa            linear   PRI 05-AUG-2025
DEFINITION  PHD finger protein 21A isoform X18 [Homo sapiens].
ACCESSION   XP_054225076
VERSION     XP_054225076.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369101.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..628
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..628
                     /product="PHD finger protein 21A isoform X18"
                     /calculated_mol_wt=68784
     CDS             1..628
                     /gene="PHF21A"
                     /gene_synonym="BHC80; BM-006; IDDBCS; NEDMS"
                     /coded_by="XM_054369101.1:338..2224"
                     /db_xref="GeneID:51317"
                     /db_xref="HGNC:HGNC:24156"
                     /db_xref="MIM:608325"
ORIGIN      
        1 melqtlqeal kveiqvhqkl vaqmkqdpqn adlkkqlhel qakitalsek qkrvveqlrk
       61 nlivkqeqpd kfqiqplpqs enklqtaqqq plqqlqqqqq yhhhhaqqsa aaspnltasq
      121 ktvttasmit tktlplvlka atatmpasvv gqrptiamvt ainsqkavls tdvqntpvnl
      181 qtsskvtgpg aeavqivakn tvtlvqatpp qpikvpqfip pprltprpnf lpqvrpkpva
      241 qnnipiapap ppmlaapqli qrpvmltkft pttlptsqns ihpvrvvngq tatiaktfpm
      301 aqltsiviat pgtrlagpqt vqlskpslek qtvkshtetd ekqtesrtit ppaapkpkre
      361 enpqklafmv slglvthdhl eeiqskrqer krrttanpvy sgavfeperk ksavtylnst
      421 mhpgtrkrgr ppkynavlgf galtptspqs shpdspenek tettftfpap vqpvslpspt
      481 stdmlkkeea ipwpgtlaiv hsyiaykaak eeekqkllkw ssdlkqereq leqkvkqlsn
      541 siskcmemkn tilarqkemh sslekvkqli rlihgidlsk pvdseatvga isngpdctpp
      601 anaatstpap spssqsctan cnqgeetk
//
LOCUS       XP_054225077             623 aa            linear   PRI 05-AUG-2025
DEFINITION  PHD finger protein 21A isoform X20 [Homo sapiens].
ACCESSION   XP_054225077
VERSION     XP_054225077.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369102.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..623
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..623
                     /product="PHD finger protein 21A isoform X20"
                     /calculated_mol_wt=68746
     Region          <382..544
                     /region_name="TNG2"
                     /note="Chromatin remodeling protein, contains PhD zinc
                     finger [Chromatin structure and dynamics]; COG5034"
                     /db_xref="CDD:227367"
     Region          498..540
                     /region_name="PHD_PHF21A"
                     /note="PHD finger found in PHD finger protein 21A
                     (PHF21A); cd15523"
                     /db_xref="CDD:276998"
     Site            order(498,505..510,530..533,535)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:276998"
     CDS             1..623
                     /gene="PHF21A"
                     /gene_synonym="BHC80; BM-006; IDDBCS; NEDMS"
                     /coded_by="XM_054369102.1:380..2251"
                     /db_xref="GeneID:51317"
                     /db_xref="HGNC:HGNC:24156"
                     /db_xref="MIM:608325"
ORIGIN      
        1 melqtlqeal kveiqvhqkl vaqmkqdpqi fflsnqnadl kkqlhelqak italsekqkr
       61 vveqlrknli vkqeqpdkfq iqplpqsenk lqtaqqqplq qlqqqqqyhh hhaqqsaaas
      121 pnltasqktv ttasmittkt lplvlkaata tmpasvvgqr ptiamvtain sqkavlstdv
      181 qntpvnlqts skvtgpgaea vqivakntvt lqvqatppqp ikvpqfippp rltprpnflp
      241 qvrpkpvaqn nipiapappp mlaapqliqr pvmltkftpt tlptsqnsih pvrvvngqta
      301 tiaktfpmaq ltsiviatpg trlagpqtvq lskpslekqt vkshtetdek qtesrtitpp
      361 aapkpkreen pqklafmvsl glvthdhlee iqskrqerkr rttanpvysg avfeperkks
      421 avtylnstmh pgtrkrgrpp kynavlgfga ltptspqssh pdspenekte ttftfpapvq
      481 pvslpsptst dgdihedfcs vcrksgqllm cdtcsrvyhl dcldpplkti pkgmwicprc
      541 qdqmlkkeea ipwpgtlaiv hsyiaykaak eeekqkllkw ssdlkqereq leqkvkqlsn
      601 sisspervgp svrpslalss tpc
//
LOCUS       XP_054225078             615 aa            linear   PRI 05-AUG-2025
DEFINITION  PHD finger protein 21A isoform X21 [Homo sapiens].
ACCESSION   XP_054225078
VERSION     XP_054225078.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369103.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..615
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..615
                     /product="PHD finger protein 21A isoform X21"
                     /calculated_mol_wt=67768
     Region          <374..536
                     /region_name="TNG2"
                     /note="Chromatin remodeling protein, contains PhD zinc
                     finger [Chromatin structure and dynamics]; COG5034"
                     /db_xref="CDD:227367"
     Region          490..532
                     /region_name="PHD_PHF21A"
                     /note="PHD finger found in PHD finger protein 21A
                     (PHF21A); cd15523"
                     /db_xref="CDD:276998"
     Site            order(490,497..502,522..525,527)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:276998"
     CDS             1..615
                     /gene="PHF21A"
                     /gene_synonym="BHC80; BM-006; IDDBCS; NEDMS"
                     /coded_by="XM_054369103.1:651..2498"
                     /db_xref="GeneID:51317"
                     /db_xref="HGNC:HGNC:24156"
                     /db_xref="MIM:608325"
ORIGIN      
        1 melqtlqeal kveiqvhqkl vaqmkqdpqn adlkkqlhel qakitalsek qkrvveqlrk
       61 nlivkqeqpd kfqiqplpqs enklqtaqqq plqqlqqqqq yhhhhaqqsa aaspnltasq
      121 tvttasmitt ktlplvlkaa tatmpasvvg qrptiamvta insqkavlst dvqntpvnlq
      181 tsskvtgpga eavqivaknt vtlqvqatpp qpikvpqfip pprltprpnf lpqvrpkpva
      241 qnnipiapap ppmlaapqli qrpvmltkft pttlptsqns ihpvrvvngq tatiaktfpm
      301 aqltsiviat pgtrlagpqt vqlskpslek qtvkshtetd ekqtesrtit ppaapkpkre
      361 enpqklafmv slglvthdhl eeiqskrqer krrttanpvy sgavfeperk ksavtylnst
      421 mhpgtrkrgr ppkynavlgf galtptspqs shpdspenek tettftfpap vqpvslpspt
      481 stdgdihedf csvcrksgql lmcdtcsrvy hldcldpplk tipkgmwicp rcqdqmlkke
      541 eaipwpgtla ivhsyiayka akeeekqkll kwssdlkqer eqleqkvkql snsissperv
      601 gpsvrpslal sstpc
//
LOCUS       XP_054225080             940 aa            linear   PRI 05-AUG-2025
DEFINITION  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225080
VERSION     XP_054225080.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369105.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..940
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..940
                     /product="cGMP-dependent 3',5'-cyclic phosphodiesterase
                     isoform X1"
                     /calculated_mol_wt=105331
     Region          240..386
                     /region_name="GAF"
                     /note="Domain present in phytochromes and cGMP-specific
                     phosphodiesterases; smart00065"
                     /db_xref="CDD:214500"
     Region          408..557
                     /region_name="GAF"
                     /note="Domain present in phytochromes and cGMP-specific
                     phosphodiesterases; smart00065"
                     /db_xref="CDD:214500"
     Region          654..887
                     /region_name="PDEase_I"
                     /note="3'5'-cyclic nucleotide phosphodiesterase;
                     pfam00233"
                     /db_xref="CDD:459723"
     CDS             1..940
                     /gene="PDE2A"
                     /gene_synonym="CGS-PDE; cGSPDE; IDDPADS; PDE2A1; PED2A4"
                     /coded_by="XM_054369105.1:74..2896"
                     /db_xref="GeneID:5138"
                     /db_xref="HGNC:HGNC:8777"
                     /db_xref="MIM:602658"
ORIGIN      
        1 mppihgclyw glplgdrkgm gvsgaqasld plakepgppg srddrledal lslgsvidis
       61 glqravkeal savlprvetv ytylldgesq lvcedpphel pqegkvreai isqkrlgcng
      121 lgfsdlpgkp larlvaplap dtqvlvmpla dkeagavaav ilvhcgqlsd neewslqave
      181 khtlvalrrv qvlqqrgpre apravqnppe gtaedqkgga aytdrdrkil qlcgelydld
      241 asslqlkvlq ylqqetrasr cclllvsedn lqlsckvigd kvlgeevsfp ltgclgqvve
      301 dkksiqlkdl tsedvqqlqs mlgcelqaml cvpvisratd qvvalacafn klegdlftde
      361 dehviqhcfh ytstvltstl afqkeqklkc ecqallqvak nlfthlddvs vllqeiitea
      421 rnlsnaeics vflldqnelv akvfdggvvd desyeiripa dqgiaghvat tgqilnipda
      481 yahplfyrgv ddstgfrtrn ilcfpiknen qevigvaelv nkingpwfsk fdedlatafs
      541 iycgisiahs llykkvneaq yrshlanemm myhmkvsdde ytkllhdgiq pvaaidsnfa
      601 sftytprslp eddtsmails mlqdmnfinn ykidcptlar fclmvkkgyr dppyhnwmha
      661 fsvshfcyll yknleltnyl edieifalfi scmchdldhr gtnnsfqvas ksvlaalyss
      721 egsvmerhhf aqaiailnth gcnifdhfsr kdyqrmldlm rdiilatdla hhlrifkdlq
      781 kmaevgydrn nkqhhrlllc llmtscdlsd qtkgwkttrk iaeliykeff sqgdlekamg
      841 nrpmemmdre kayipelqis fmehiampiy kllqdlfpka aelyervasn rehwtkvshk
      901 ftirglpsnn sldfldeeye vpdldgtrap ingccsldae
//
LOCUS       XP_054225081             114 aa            linear   PRI 05-AUG-2025
DEFINITION  trafficking protein particle complex subunit 4 isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225081
VERSION     XP_054225081.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369106.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..114
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..114
                     /product="trafficking protein particle complex subunit 4
                     isoform X1"
                     /calculated_mol_wt=12610
     Region          <13..100
                     /region_name="TRAPPC4_synbindin"
                     /note="Trafficking protein particle complex subunit 4;
                     cd14856"
                     /db_xref="CDD:341446"
     Site            order(27,43..48,66,69..70,72..74,77..79,82)
                     /site_type="other"
                     /note="TRAPPC3 interface [polypeptide binding]"
                     /db_xref="CDD:341446"
     Site            order(74,77..80,92)
                     /site_type="other"
                     /note="TRAPPC5 interface [polypeptide binding]"
                     /db_xref="CDD:341446"
     CDS             1..114
                     /gene="TRAPPC4"
                     /gene_synonym="CGI-104; HSPC172; NEDESBA; PTD009; SBDN;
                     SYNBINDIN; TRS23"
                     /coded_by="XM_054369106.1:250..594"
                     /db_xref="GeneID:51399"
                     /db_xref="HGNC:HGNC:19943"
                     /db_xref="MIM:610971"
ORIGIN      
        1 mknatdpdld frlfaigsql speqgssgie mletdtfklh cyqtltgikf vvladprqag
       61 idsllrkiye iysdfalknp fyslempirc elfdqnlkla levaekagtf gpgs
//
LOCUS       XP_054225082             735 aa            linear   PRI 05-AUG-2025
DEFINITION  cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225082
VERSION     XP_054225082.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369107.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..735
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..735
                     /product="cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B
                     isoform X1"
                     /calculated_mol_wt=81442
     Region          <190..263
                     /region_name="CynX"
                     /note="Cyanate permease [Inorganic ion transport and
                     metabolism]; COG2807"
                     /db_xref="CDD:442057"
     CDS             1..735
                     /gene="PDE3B"
                     /gene_synonym="cGIPDE1; HcGIP1"
                     /coded_by="XM_054369107.1:273..2480"
                     /db_xref="GeneID:5140"
                     /db_xref="HGNC:HGNC:8779"
                     /db_xref="MIM:602047"
ORIGIN      
        1 mrrderdaka mrslqppdga gsppeslrng yvkscvsplr qdpprgfffh lcrfcnvelr
       61 pppaspqqpr rcspfcrarl slgalaafvl alllgaepes waagaawlrt llsvcshsls
      121 plfsiacaff fltcfltrtk rgpgpgrscg swwllalpac cylgdflvwq wwswpwgdgd
      181 agsaaphtpp eaaagrlllv lscvgllltl ahplrlrhcv lvlllasfvw wvsftslgsl
      241 psalrpllsg lvggagclla lgldhffqir eaplhprlss aaeekvpvir prrrsscvsl
      301 getaasyygs ckifrrpslp cisreqmilw dwdlkqwykp hyqnsgggng vdlsvlnear
      361 nmvsdlltdp slppqvissl rsisslmgaf sgscrpkinp ltpfpgfypc seiedpaekg
      421 drklnkglnr nslptpqlrr ssgtsgllpv eqssrwdrnn gkrphqefgi ssqgcylngp
      481 fnsnlltipk qrsssvslth hvglrragvl sslspvnssn hgpvstgslt nrspiefpdt
      541 adflnkpsvi lqrslgnapn tpdfyqqlrn sdsnlcnscg hqmlkyvsts esdgtdccsg
      601 ksgeeenifs kesfklmetq qeeetekkds rklfqegdkw lteeaqseqq tnieqevsld
      661 lilveeydsl iekmsnwnfp ifelvekmge ksgrilsqvm ytlfqdtgll eifkiptqqf
      721 mnyfraleng yrdip
//
LOCUS       XP_054225083             659 aa            linear   PRI 05-AUG-2025
DEFINITION  cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform X2 [Homo
            sapiens].
ACCESSION   XP_054225083
VERSION     XP_054225083.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369108.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..659
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..659
                     /product="cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B
                     isoform X2"
                     /calculated_mol_wt=72387
     Region          <190..263
                     /region_name="CynX"
                     /note="Cyanate permease [Inorganic ion transport and
                     metabolism]; COG2807"
                     /db_xref="CDD:442057"
     CDS             1..659
                     /gene="PDE3B"
                     /gene_synonym="cGIPDE1; HcGIP1"
                     /coded_by="XM_054369108.1:273..2252"
                     /db_xref="GeneID:5140"
                     /db_xref="HGNC:HGNC:8779"
                     /db_xref="MIM:602047"
ORIGIN      
        1 mrrderdaka mrslqppdga gsppeslrng yvkscvsplr qdpprgfffh lcrfcnvelr
       61 pppaspqqpr rcspfcrarl slgalaafvl alllgaepes waagaawlrt llsvcshsls
      121 plfsiacaff fltcfltrtk rgpgpgrscg swwllalpac cylgdflvwq wwswpwgdgd
      181 agsaaphtpp eaaagrlllv lscvgllltl ahplrlrhcv lvlllasfvw wvsftslgsl
      241 psalrpllsg lvggagclla lgldhffqir eaplhprlss aaeekvpvir prrrsscvsl
      301 getaasyygs ckifrrpslp cisreqmilw dwdlkqwykp hyqnsgggng vdlsvlnear
      361 nmvsdlltdp slppqvissl rsisslmgaf sgscrpkinp ltpfpgfypc seiedpaekg
      421 drklnkglnr nslptpqlrr ssgtsgllpv eqssrwdrnn gkrphqefgi ssqgcylngp
      481 fnsnlltipk qrsssvslth hvglrragvl sslspvnssn hgpvstgslt nrspiefpdt
      541 adflnkpsvi lqrslgnapn tpdfyqqlrn sdsnlcnscg hqmlkyvsts esdgtdccsg
      601 ksgeeenifs kesfklmetq qeeetekkds rklfqegdkw lteeaqseqq tnvkdklsi
//
LOCUS       XP_054225084             437 aa            linear   PRI 05-AUG-2025
DEFINITION  protein phosphatase methylesterase 1 isoform X1 [Homo sapiens].
ACCESSION   XP_054225084
VERSION     XP_054225084.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369109.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..437
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..437
                     /product="protein phosphatase methylesterase 1 isoform X1"
                     /calculated_mol_wt=47881
     Region          66..>229
                     /region_name="MenH"
                     /note="2-succinyl-6-hydroxy-2,
                     4-cyclohexadiene-1-carboxylate synthase MenH and related
                     esterases, alpha/beta hydrolase fold [Coenzyme transport
                     and metabolism, General function prediction only];
                     COG0596"
                     /db_xref="CDD:440361"
     CDS             1..437
                     /gene="PPME1"
                     /gene_synonym="ABDH19; PME-1"
                     /coded_by="XM_054369109.1:134..1447"
                     /db_xref="GeneID:51400"
                     /db_xref="HGNC:HGNC:30178"
                     /db_xref="MIM:611117"
ORIGIN      
        1 msaleksmhl grlpsrpplp gsggsqsgak mrmgpgrkrd fspvpwsqyf esmedveven
       61 etgkdtfrvy ksgsegpvll llhggghsal swavftaaii srvqcrival dlrshgetkv
      121 knpedlsaet makdvgnvve amygdlpppi mlighsmgga iavhtassnl vpsllglcmi
      181 dvvegtamda lnsmqnflrg rpktfkslen aiewsvksgq irnlesarvs mvgqvkqceg
      241 itspegsksi vegiieeeee deegsesisk rkkeddmetk kdhpytwrie laktekywdg
      301 wfrglsnlfl scpipkllll agvdrldkdl tigqmqgkfq mqvlpqcgha vhedapdkvs
      361 lvlsdckrtt vritldvted kslslslhcl qqllwslcrc sstssptspw qllmvlvlci
      421 caeelltlcy fipgpcg
//
LOCUS       XP_054225085             278 aa            linear   PRI 05-AUG-2025
DEFINITION  protein phosphatase methylesterase 1 isoform X2 [Homo sapiens].
ACCESSION   XP_054225085
VERSION     XP_054225085.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369110.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..278
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..278
                     /product="protein phosphatase methylesterase 1 isoform X2"
                     /calculated_mol_wt=29945
     Region          66..>229
                     /region_name="MenH"
                     /note="2-succinyl-6-hydroxy-2,
                     4-cyclohexadiene-1-carboxylate synthase MenH and related
                     esterases, alpha/beta hydrolase fold [Coenzyme transport
                     and metabolism, General function prediction only];
                     COG0596"
                     /db_xref="CDD:440361"
     CDS             1..278
                     /gene="PPME1"
                     /gene_synonym="ABDH19; PME-1"
                     /coded_by="XM_054369110.1:134..970"
                     /db_xref="GeneID:51400"
                     /db_xref="HGNC:HGNC:30178"
                     /db_xref="MIM:611117"
ORIGIN      
        1 msaleksmhl grlpsrpplp gsggsqsgak mrmgpgrkrd fspvpwsqyf esmedveven
       61 etgkdtfrvy ksgsegpvll llhggghsal swavftaaii srvqcrival dlrshgetkv
      121 knpedlsaet makdvgnvve amygdlpppi mlighsmgga iavhtassnl vpsllglcmi
      181 dvvegtamda lnsmqnflrg rpktfkslen aiewsvksgq irnlesarvs mvgqvkqceg
      241 itspegsksi vegiieeeee deegsesisk rkkeddme
//
LOCUS       XP_054225086             179 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Hikeshi isoform X1 [Homo sapiens].
ACCESSION   XP_054225086
VERSION     XP_054225086.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369111.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..179
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..179
                     /product="protein Hikeshi isoform X1"
                     /calculated_mol_wt=19117
     Region          1..179
                     /region_name="DUF775"
                     /note="Protein of unknown function (DUF775); pfam05603"
                     /db_xref="CDD:461690"
     CDS             1..179
                     /gene="HIKESHI"
                     /gene_synonym="C11orf73; HLD13; HSPC138; HSPC179; L7RN6;
                     OPI10"
                     /coded_by="XM_054369111.1:210..749"
                     /db_xref="GeneID:51501"
                     /db_xref="HGNC:HGNC:26938"
                     /db_xref="MIM:614908"
ORIGIN      
        1 mfgclvagrl vqtaaqqvae dkfvfdlpdy esinhvvvfm lgtipfpegm ggsvyfsypd
       61 sngmpvwqll gfvtngkpsa ifkisglksg egsqhpfgam nivrtpsvaq igisvellds
      121 maqqtpvgna avssvdsftq ftqkmldnfy nfassfavsq aqmtpspsem fipanvvlk
//
LOCUS       XP_054225087             109 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Hikeshi isoform X3 [Homo sapiens].
ACCESSION   XP_054225087
VERSION     XP_054225087.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369112.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..109
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..109
                     /product="protein Hikeshi isoform X3"
                     /calculated_mol_wt=12080
     Region          <3..107
                     /region_name="DUF775"
                     /note="Protein of unknown function (DUF775); pfam05603"
                     /db_xref="CDD:461690"
     CDS             1..109
                     /gene="HIKESHI"
                     /gene_synonym="C11orf73; HLD13; HSPC138; HSPC179; L7RN6;
                     OPI10"
                     /coded_by="XM_054369112.1:230..559"
                     /db_xref="GeneID:51501"
                     /db_xref="HGNC:HGNC:26938"
                     /db_xref="MIM:614908"
ORIGIN      
        1 mregsqhpfg amnivrtpsv aqigisvell dsmaqqtpvg naavssvdsf tqftqkmldn
       61 fynfassfav sqaqmtpsps emfipanvvl kwyenfqrrl aqnplfwkt
//
LOCUS       XP_054225088             125 aa            linear   PRI 05-AUG-2025
DEFINITION  multifunctional methyltransferase subunit TRM112-like protein
            isoform X1 [Homo sapiens].
ACCESSION   XP_054225088
VERSION     XP_054225088.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369113.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..125
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..125
                     /product="multifunctional methyltransferase subunit
                     TRM112-like protein isoform X1"
                     /calculated_mol_wt=14068
     Region          2..118
                     /region_name="Trm112-like"
                     /note="eukaryotic tRNA methyltransferase 112, a partner
                     protein of both rRNA/tRNA and protein methyltransferases,
                     and similar proteins; cd21089"
                     /db_xref="CDD:411041"
     Site            order(2,5,7..10,12,21,38,41,44,48,50,111,113..117)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:411041"
     CDS             1..125
                     /gene="TRMT112"
                     /gene_synonym="HSPC152; HSPC170; hTrm112; TRM112;
                     TRMT11-2"
                     /coded_by="XM_054369113.1:314..691"
                     /db_xref="GeneID:51504"
                     /db_xref="HGNC:HGNC:26940"
                     /db_xref="MIM:618630"
ORIGIN      
        1 mkllthnlls shvrgvgsrg fplrlqatev ricpvefnpn fvarmipkve wsafleaadn
       61 lrliqvpkgp vegyeeneef lrtmhhllle veviegtlqc pesgrmfpis rgipnmllse
      121 eetes
//
LOCUS       XP_054225089             125 aa            linear   PRI 05-AUG-2025
DEFINITION  multifunctional methyltransferase subunit TRM112-like protein
            isoform X1 [Homo sapiens].
ACCESSION   XP_054225089
VERSION     XP_054225089.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369114.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..125
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..125
                     /product="multifunctional methyltransferase subunit
                     TRM112-like protein isoform X1"
                     /calculated_mol_wt=14068
     Region          2..118
                     /region_name="Trm112-like"
                     /note="eukaryotic tRNA methyltransferase 112, a partner
                     protein of both rRNA/tRNA and protein methyltransferases,
                     and similar proteins; cd21089"
                     /db_xref="CDD:411041"
     Site            order(2,5,7..10,12,21,38,41,44,48,50,111,113..117)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:411041"
     CDS             1..125
                     /gene="TRMT112"
                     /gene_synonym="HSPC152; HSPC170; hTrm112; TRM112;
                     TRMT11-2"
                     /coded_by="XM_054369114.1:337..714"
                     /db_xref="GeneID:51504"
                     /db_xref="HGNC:HGNC:26940"
                     /db_xref="MIM:618630"
ORIGIN      
        1 mkllthnlls shvrgvgsrg fplrlqatev ricpvefnpn fvarmipkve wsafleaadn
       61 lrliqvpkgp vegyeeneef lrtmhhllle veviegtlqc pesgrmfpis rgipnmllse
      121 eetes
//
LOCUS       XP_054225091             147 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 138 isoform X4 [Homo sapiens].
ACCESSION   XP_054225091
VERSION     XP_054225091.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369116.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..147
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..147
                     /product="transmembrane protein 138 isoform X4"
                     /calculated_mol_wt=16707
     Region          38..>100
                     /region_name="TMEM138"
                     /note="Transmembrane protein 138; pfam14935"
                     /db_xref="CDD:434328"
     CDS             1..147
                     /gene="TMEM138"
                     /gene_synonym="HSPC196"
                     /coded_by="XM_054369116.1:187..630"
                     /db_xref="GeneID:51524"
                     /db_xref="HGNC:HGNC:26944"
                     /db_xref="MIM:614459"
ORIGIN      
        1 mlqtsnyslv lslqflllsy dlfvnsfsel lqktpviqlv lfiiqdiavl fniiiiflmf
       61 fntfvfqagl vnllfhkfkg tiiltavyfa lsislhvwvm kevevpgkkq sntrvsgcfl
      121 krilcpgsws qnrswlctik avnlikp
//
LOCUS       XP_054225094            1438 aa            linear   PRI 05-AUG-2025
DEFINITION  pre-mRNA cleavage complex 2 protein Pcf11 isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225094
VERSION     XP_054225094.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369119.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1438
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1438
                     /product="pre-mRNA cleavage complex 2 protein Pcf11
                     isoform X1"
                     /calculated_mol_wt=159076
     Region          19..145
                     /region_name="CID_Pcf11"
                     /note="CID (CTD-Interacting Domain) of Pcf11; cd16982"
                     /db_xref="CDD:340779"
     Site            order(34..35,37,75,78..79,82..83,114,118,121)
                     /site_type="other"
                     /note="CTD binding site [polypeptide binding]"
                     /db_xref="CDD:340779"
     Region          <196..467
                     /region_name="Mplasa_alph_rch"
                     /note="helix-rich Mycoplasma protein; TIGR04523"
                     /db_xref="CDD:275316"
     Region          <374..616
                     /region_name="PTZ00108"
                     /note="DNA topoisomerase 2-like protein; Provisional"
                     /db_xref="CDD:240271"
     Region          <1162..>1304
                     /region_name="gly_rich_SclB"
                     /note="LPXTG-anchored collagen-like adhesin Scl2/SclB;
                     NF038329"
                     /db_xref="CDD:468478"
     CDS             1..1438
                     /gene="PCF11"
                     /coded_by="XM_054369119.1:310..4626"
                     /db_xref="GeneID:51585"
                     /db_xref="HGNC:HGNC:30097"
                     /db_xref="MIM:608876"
ORIGIN      
        1 mseqtpaeag aagaredacr dyqssledlt fnskphinml tilaeenlpf akeivsliea
       61 qtakapssek lpvmylmdsi vknvgreylt aftknlvatf icvfekvden trkslfklrs
      121 twdeifplkk lyaldvrvns ldpawpikpl ppnvntssih vnpkflnksp eepstpgtvv
      181 sspsistppi vpdiqknltq eqlirqqlla kqkqllelqq kkleleleqa kaqlavslsv
      241 qqetsnlgpg sapsklhvsq ippmavkaph qvpvqseksr pgpslqiqdl kgtnrdprln
      301 risqhshgkd qshrkeflmn tlnqsdtkts ktipseklns skqeksksge kitkkeldql
      361 dsksksksks psplknklsh tkdlknqese smrlsdmnkr dprlkkhlqd ktdgkdddvk
      421 ekrktaekkd kdehmksseh rlagsrnkii ngivqkqdti teesekqgtk pgrsstrkrs
      481 rsrspksrsp iihspkrrdr rspkrrqrsm sptstpkagk irqsgakqsh meeftppsre
      541 drnakrstkq dirdprrmkk teeerpqett nqhstksgte pkenvenwqs sksakrwksg
      601 weenkslqqv dehskpphlr hreswsstkg ilsprapkqq qhrlsvdanl qipkeltlas
      661 krellqktse rlasgeitqd dflvvvhqir qlfqyqegkh rcnvrdspte enkgglkkkp
      721 llsdaeltyy ehkaklkrtq vqhsfprldl ldpdifdypl tdallsgiec epskskhasr
      781 nsgaqfdrke qfserarrls pisgsrtyae nlsphegrrr hdeqvsakgv reeqrspfnd
      841 rfplkrprye dsdkpfvdsp asrfagldtn qrltalaedr plfdgpsrps vardgptkmi
      901 fegpnklspr idgpptpasl rfdgspgqmg gggplrfegp qgqlgggcpl rfegppgpvg
      961 tplrfegpig qaggggfrfe gspglrfegs pgglrfegpg gqpvgglrfe ghrgqpvggl
     1021 rfegphgqpv gglrfdnprg qpvgglrfeg ghgpsgaair fdgphgqpgg girfegpllq
     1081 qgvgmrfegp hgqsvaglrf egqhnqlggn lrfegphgqp gvgirfegpl vqqgggmrfe
     1141 gpsvpggglr iegplgqggp rfegchalrf dgqpgqpsll prfdglhgqp gprfertpgq
     1201 pgpqrfdgpp gqqvqprfdg vpqrfdgpqh qqasrfdipl glqgtrfdnh psqrlesvsf
     1261 nqtgpyndpp gnafnapsqg lqfqrheqif dspqgpnfng phgpgnqsfs nplnrasghy
     1321 fdeknlqssq fgnfgnipap mtvgniqasq qvlsgvaqpv afgqgqqflp vhpqnpgfvq
     1381 npsgalpkay pdnhlsqvdv nelfskllkt gilklsqtds attqntwrmv lrnlyvss
//
LOCUS       XP_054225095             202 aa            linear   PRI 05-AUG-2025
DEFINITION  large ribosomal subunit protein mL48 isoform X1 [Homo sapiens].
ACCESSION   XP_054225095
VERSION     XP_054225095.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369120.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 4% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..202
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..202
                     /product="large ribosomal subunit protein mL48 isoform X1"
                     /calculated_mol_wt=22112
     Region          82..177
                     /region_name="Ribosomal_S10"
                     /note="Ribosomal protein S10p/S20e; pfam00338"
                     /db_xref="CDD:459769"
     CDS             1..202
                     /gene="MRPL48"
                     /gene_synonym="CGI-118; HSPC290; L48MT; mL48; MRP-L48"
                     /coded_by="XM_054369120.1:410..1018"
                     /db_xref="GeneID:51642"
                     /db_xref="HGNC:HGNC:16653"
                     /db_xref="MIM:611853"
ORIGIN      
        1 miiapcslel lgssnppasa sgvagitggi llsisrpykt kpthgigkyk hlikaeepkk
       61 kkgkvevrai nlgtdyeygv lnihltaydm tlaesyaqyv hnlcnslsik veesyamptk
      121 tievlqlqdq gskmlldsvl tthervvqis glsatfaeif leiiqsslpe gvrlsvkeht
      181 eedfkgrfka rpeleellak lk
//
LOCUS       XP_054225096             113 aa            linear   PRI 05-AUG-2025
DEFINITION  large ribosomal subunit protein mL48 isoform X2 [Homo sapiens].
ACCESSION   XP_054225096
VERSION     XP_054225096.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369121.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..113
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..113
                     /product="large ribosomal subunit protein mL48 isoform X2"
                     /calculated_mol_wt=12639
     Region          1..88
                     /region_name="Ribosomal_S10"
                     /note="Ribosomal protein S10p/S20e; pfam00338"
                     /db_xref="CDD:459769"
     CDS             1..113
                     /gene="MRPL48"
                     /gene_synonym="CGI-118; HSPC290; L48MT; mL48; MRP-L48"
                     /coded_by="XM_054369121.1:138..479"
                     /db_xref="GeneID:51642"
                     /db_xref="HGNC:HGNC:16653"
                     /db_xref="MIM:611853"
ORIGIN      
        1 mtlaesyaqy vhnlcnslsi kveesyampt ktievlqlqd qgskmlldsv ltthervvqi
       61 sglsatfaei fleiiqsslp egvrlsvkeh teedfkgrfk arpeleella klk
//
LOCUS       XP_054225097             336 aa            linear   PRI 05-AUG-2025
DEFINITION  NADH-cytochrome b5 reductase 2 isoform X4 [Homo sapiens].
ACCESSION   XP_054225097
VERSION     XP_054225097.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369122.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..336
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..336
                     /product="NADH-cytochrome b5 reductase 2 isoform X4"
                     /calculated_mol_wt=37832
     Region          80..336
                     /region_name="cyt_b5_reduct_like"
                     /note="Cytochrome b5 reductase catalyzes the reduction of
                     2 molecules of cytochrome b5 using NADH as an electron
                     donor. Like ferredoxin reductases, these proteins have an
                     N-terminal FAD binding subdomain and a C-terminal NADH
                     binding subdomain, separated by a...; cd06183"
                     /db_xref="CDD:99780"
     Site            order(113,127..130,144..146,148,159..163,217,220..221,336)
                     /site_type="other"
                     /note="FAD binding pocket [chemical binding]"
                     /db_xref="CDD:99780"
     Site            order(127,129..130)
                     /site_type="other"
                     /note="FAD binding motif [chemical binding]"
                     /db_xref="CDD:99780"
     Site            order(146,148,217..218,244..246,275,287,310..314)
                     /site_type="other"
                     /note="NAD binding pocket [chemical binding]"
                     /db_xref="CDD:99780"
     Site            order(160,163,166,172,180,182)
                     /site_type="other"
                     /note="phosphate binding motif [ion binding]"
                     /db_xref="CDD:99780"
     Site            order(212,216..219,221)
                     /site_type="other"
                     /note="beta-alpha-beta structure motif"
                     /db_xref="CDD:99780"
     CDS             1..336
                     /gene="CYB5R2"
                     /gene_synonym="B5R.2"
                     /coded_by="XM_054369122.1:2742..3752"
                     /db_xref="GeneID:51700"
                     /db_xref="HGNC:HGNC:24376"
                     /db_xref="MIM:608342"
ORIGIN      
        1 mnerrsarst rlqlgdapas apprkhpprt rprvgahedp sllltitvtg vtvlvlvlks
       61 mnsrrrepit lqdpeakypl pliekekish ntrrfrfglp spdhvlglpv gnyvqllaki
      121 dnelvvrayt pvssdddrgf vdliikiyfk nvhpqypegg kmtqylenmk igetiffrgp
      181 rgrlfyhgpg nlgirpdqts epkktladhl gmiaggtgit pmlqlirhit kdpsdrtrms
      241 lifanqteed ilvrkeleei arthpdqfdl wytldrppig wkyssgfvta dmikehlppp
      301 akstlilvcg pppliqtaah pnleklgytq dmifty
//
LOCUS       XP_054225098             333 aa            linear   PRI 05-AUG-2025
DEFINITION  NADH-cytochrome b5 reductase 2 isoform X5 [Homo sapiens].
ACCESSION   XP_054225098
VERSION     XP_054225098.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369123.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..333
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..333
                     /product="NADH-cytochrome b5 reductase 2 isoform X5"
                     /calculated_mol_wt=37456
     Region          <68..277
                     /region_name="PLN02252"
                     /note="nitrate reductase [NADPH]"
                     /db_xref="CDD:215141"
     CDS             1..333
                     /gene="CYB5R2"
                     /gene_synonym="B5R.2"
                     /coded_by="XM_054369123.1:128..1129"
                     /db_xref="GeneID:51700"
                     /db_xref="HGNC:HGNC:24376"
                     /db_xref="MIM:608342"
ORIGIN      
        1 mnerrsarst rlqlgdapas apprkhpprt rprvgahedp sllltitvtg vtvlvlvlks
       61 mnsrrrepit lqdpeakypl pliekekish ntrrfrfglp spdhvlglpv gnyvqllaki
      121 dnelvvrayt pvssdddrgf vdliikiyfk nvhpqypegg kmtqylenmk igetiffrgp
      181 rgrlfyhgpg nlgirpdqts epkktladhl gmiaggtgit pmlqlirhit kdpsdrtrms
      241 lifanqteed ilvrkeleei arthpdqfdl wytldrppig ttssalthhg saptldhfed
      301 wslvgrgryp teqfcavplt pghtlpdnss wly
//
LOCUS       XP_054225099             297 aa            linear   PRI 05-AUG-2025
DEFINITION  NADH-cytochrome b5 reductase 2 isoform X6 [Homo sapiens].
ACCESSION   XP_054225099
VERSION     XP_054225099.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369124.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..297
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..297
                     /product="NADH-cytochrome b5 reductase 2 isoform X6"
                     /calculated_mol_wt=33416
     Region          <68..282
                     /region_name="PLN02252"
                     /note="nitrate reductase [NADPH]"
                     /db_xref="CDD:215141"
     CDS             1..297
                     /gene="CYB5R2"
                     /gene_synonym="B5R.2"
                     /coded_by="XM_054369124.1:122..1015"
                     /db_xref="GeneID:51700"
                     /db_xref="HGNC:HGNC:24376"
                     /db_xref="MIM:608342"
ORIGIN      
        1 mnerrsarst rlqlgdapas apprkhpprt rprvgahedp sllltitvtg vtvlvlvlks
       61 mnsrrrepit lqdpeakypl pliekekish ntrrfrfglp spdhvlglpv gnyvqllaki
      121 dnelvvrayt pvssdddrgf vdliikiyfk nvhpqypegg kmtqylenmk igetiffrgp
      181 rgrlfyhgpg nlgirpdqts epkktladhl gmiaggtgit pmlqlirhit kdpsdrtrms
      241 lifanqteed ilvrkeleei arthpdqfdl wytldrppig pwsaegatll snsaqfh
//
LOCUS       XP_054225100             276 aa            linear   PRI 05-AUG-2025
DEFINITION  NADH-cytochrome b5 reductase 2 isoform X1 [Homo sapiens].
ACCESSION   XP_054225100
VERSION     XP_054225100.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369125.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..276
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..276
                     /product="NADH-cytochrome b5 reductase 2 isoform X1"
                     /calculated_mol_wt=31328
     Region          <8..276
                     /region_name="PLN02252"
                     /note="nitrate reductase [NADPH]"
                     /db_xref="CDD:215141"
     CDS             1..276
                     /gene="CYB5R2"
                     /gene_synonym="B5R.2"
                     /coded_by="XM_054369125.1:150..980"
                     /db_xref="GeneID:51700"
                     /db_xref="HGNC:HGNC:24376"
                     /db_xref="MIM:608342"
ORIGIN      
        1 mnsrrrepit lqdpeakypl pliekekish ntrrfrfglp spdhvlglpv gnyvqllaki
       61 dnelvvrayt pvssdddrgf vdliikiyfk nvhpqypegg kmtqylenmk igetiffrgp
      121 rgrlfyhgpg nlgirpdqts epkktladhl gmiaggtgit pmlqlirhit kdpsdrtrms
      181 lifanqteed ilvrkeleei arthpdqfdl wytldrppig wkyssgfvta dmikehlppp
      241 akstlilvcg pppliqtaah pnleklgytq dmifty
//
LOCUS       XP_054225101             258 aa            linear   PRI 05-AUG-2025
DEFINITION  NADH-cytochrome b5 reductase 2 isoform X7 [Homo sapiens].
ACCESSION   XP_054225101
VERSION     XP_054225101.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369126.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..258
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..258
                     /product="NADH-cytochrome b5 reductase 2 isoform X7"
                     /calculated_mol_wt=28638
     Region          <68..245
                     /region_name="PLN02252"
                     /note="nitrate reductase [NADPH]"
                     /db_xref="CDD:215141"
     CDS             1..258
                     /gene="CYB5R2"
                     /gene_synonym="B5R.2"
                     /coded_by="XM_054369126.1:122..898"
                     /db_xref="GeneID:51700"
                     /db_xref="HGNC:HGNC:24376"
                     /db_xref="MIM:608342"
ORIGIN      
        1 mnerrsarst rlqlgdapas apprkhpprt rprvgahedp sllltitvtg vtvlvlvlks
       61 mnsrrrepit lqdpeakypl pliekekish ntrrfrfglp spdhvlglpv gnyvqllaki
      121 dnelvvrayt pvssdddrgf vdliikiyfk nvhpqypegg kmtqylenmk igetiffrgp
      181 rgrlfyhgpg nlgirpdqts epkktladhl gmiaggtgit pmlqlirhit kdpsdrtrms
      241 lifanqagst aqasllpt
//
LOCUS       XP_054225102            1438 aa            linear   PRI 05-AUG-2025
DEFINITION  remodeling and spacing factor 1 isoform X1 [Homo sapiens].
ACCESSION   XP_054225102
VERSION     XP_054225102.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369127.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1438
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1438
                     /product="remodeling and spacing factor 1 isoform X1"
                     /calculated_mol_wt=163376
     Region          96..142
                     /region_name="WHIM1"
                     /note="WSTF, HB1, Itc1p, MBD9 motif 1; pfam15612"
                     /db_xref="CDD:464774"
     Region          890..935
                     /region_name="PHD_RSF1"
                     /note="PHD finger found in Remodeling and spacing factor 1
                     (Rsf-1); cd15543"
                     /db_xref="CDD:277018"
     Site            order(890,902..906,910,930)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277018"
     Region          912..>965
                     /region_name="BAH"
                     /note="or Bromo Adjacent Homology domain (also called ELM1
                     and BAM for Bromo Adjacent Motif). BAH domains have first
                     been described as domains found in the polybromo protein
                     and Yeast Rsc1/Rsc2 (Remodeling of the Structure of
                     Chromatin). They also occur in...; cl02608"
                     /db_xref="CDD:470629"
     CDS             1..1438
                     /gene="RSF1"
                     /gene_synonym="HBXAP; p325; RSF-1; XAP8"
                     /coded_by="XM_054369127.1:9..4325"
                     /db_xref="GeneID:51773"
                     /db_xref="HGNC:HGNC:18118"
                     /db_xref="MIM:608522"
ORIGIN      
        1 mataaaaaav mappgcpgsc pnfavvcsfl erygplldlp elpfpelerv lqapppdvgn
       61 gevpkelvel hlklmrkigk svtadrweky likicqefns twawemekkg ylemsveckl
      121 allkylcecq fddnlkfkni ineedadtmr lqpigrdkdg lmywyqldqd hnvrmyieeq
      181 ddqdgsswkc ivrnrnelae tlallkaqid pvllknssqq dnssrespsl edeetkkeee
      241 tpkqeeqkes ekmkseeqpm dlenrstanv leettvkkek edekelvklp vivklekplp
      301 eneekkiike esdsfkenvk pikvevkecr adpkdtkssm ekpvaqeper iefggnikss
      361 heitekstee teklkndqqa kiplkkreik lsddfdspvk gplcksvtpt keflkdeikq
      421 eeetckrist italghegkq lvngevsder vapnfktepi etkfyetkee syspskdrni
      481 itegngtesl nsvitsmktg eleketaplr kdadssisvl eihsqkaqie epdppemets
      541 ldssemakdl ssktalsste sctmkgeeks pktkkdkrpp ilecleklek skktfldkda
      601 qrlspipeev pkstlesekp gspeaaetsp psniidhcek lasekevvec qststvggqs
      661 vkkvdletlk edseftkvem dnldnaqtsg ieepsetkgs mqkskfkykl vpeeettase
      721 nteitserqk egikltiris srkkkpdspp kvlepenkqe ktekeeektn vgrtlrrspr
      781 isrptakvae irdqkadkkr gegedeveee stalqktdkk eilkksekdt nskvkpkgkv
      841 rwtgsrtrgr wkyssndese gsgsekssaa seeeeekese eailadddep ckkcglpnhp
      901 elillcdscd sgyhtaclrp plmiipdgew fcppcqhkll cekleeqlqd ldvalkkker
      961 aerrkerlvy vgisieniip pqepdfsedq eekkkdskks kanllerrst rtrkcisyrf
     1021 defdeaidea ieddikeadg ggvgrgkdis titghrgkdi stildeerke nkrpqraaaa
     1081 rrkkrrrlnd ldsdsnldee esedefkisd gsqdefvvsd enpdeseedp psnddsdtdf
     1141 csrrlrrhps rpmrqsrrlr rktpkkkysd ddeeeeseen srdsesdfsd dfsddfvetr
     1201 rrrsrrnqkr qinykedses dgsqkslrrg keirrvhkrr lssseseesy lsknseddel
     1261 akeskrsvrk rgrstdeyse adeeeeeeeg kpsrkrlhri etdeeescdn ahgdanqpar
     1321 dsqprvlpse qestkkpyri esdeeedfen vgkvgspldy slvdlpstng qspgkaienl
     1381 igkpteksqt pkdnstasas lasngtsggq eagapeeeed ellrvtdlvd yvcnseql
//
LOCUS       XP_054225103            1400 aa            linear   PRI 05-AUG-2025
DEFINITION  remodeling and spacing factor 1 isoform X2 [Homo sapiens].
ACCESSION   XP_054225103
VERSION     XP_054225103.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369128.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1400
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1400
                     /product="remodeling and spacing factor 1 isoform X2"
                     /calculated_mol_wt=159774
     Region          55..101
                     /region_name="WHIM1"
                     /note="WSTF, HB1, Itc1p, MBD9 motif 1; pfam15612"
                     /db_xref="CDD:464774"
     Region          852..897
                     /region_name="PHD_RSF1"
                     /note="PHD finger found in Remodeling and spacing factor 1
                     (Rsf-1); cd15543"
                     /db_xref="CDD:277018"
     Site            order(852,864..868,872,892)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277018"
     Region          874..>927
                     /region_name="BAH"
                     /note="or Bromo Adjacent Homology domain (also called ELM1
                     and BAM for Bromo Adjacent Motif). BAH domains have first
                     been described as domains found in the polybromo protein
                     and Yeast Rsc1/Rsc2 (Remodeling of the Structure of
                     Chromatin). They also occur in...; cl02608"
                     /db_xref="CDD:470629"
     CDS             1..1400
                     /gene="RSF1"
                     /gene_synonym="HBXAP; p325; RSF-1; XAP8"
                     /coded_by="XM_054369128.1:18..4220"
                     /db_xref="GeneID:51773"
                     /db_xref="HGNC:HGNC:18118"
                     /db_xref="MIM:608522"
ORIGIN      
        1 mpcflrystv degtweggke mipkelvelh lklmrkigks vtadrwekyl ikicqefnst
       61 wawemekkgy lemsveckla llkylcecqf ddnlkfknii needadtmrl qpigrdkdgl
      121 mywyqldqdh nvrmyieeqd dqdgsswkci vrnrnelaet lallkaqidp vllknssqqd
      181 nssrespsle deetkkeeet pkqeeqkese kmkseeqpmd lenrstanvl eettvkkeke
      241 dekelvklpv ivklekplpe neekkiikee sdsfkenvkp ikvevkecra dpkdtkssme
      301 kpvaqeperi efggnikssh eiteksteet eklkndqqak iplkkreikl sddfdspvkg
      361 plcksvtptk eflkdeikqe eetckristi talghegkql vngevsderv apnfktepie
      421 tkfyetkees yspskdrnii tegngtesln svitsmktge leketaplrk dadssisvle
      481 ihsqkaqiee pdppemetsl dssemakdls sktalsstes ctmkgeeksp ktkkdkrppi
      541 leclekleks kktfldkdaq rlspipeevp kstlesekpg speaaetspp sniidhcekl
      601 asekevvecq ststvggqsv kkvdletlke dseftkvemd nldnaqtsgi eepsetkgsm
      661 qkskfkyklv peeettasen teitserqke gikltiriss rkkkpdsppk vlepenkqek
      721 tekeeektnv grtlrrspri srptakvaei rdqkadkkrg egedeveees talqktdkke
      781 ilkksekdtn skvskvkpkg kvrwtgsrtr grwkyssnde segsgsekss aaseeeeeke
      841 seeailaddd epckkcglpn hpelillcds cdsgyhtacl rpplmiipdg ewfcppcqhk
      901 llcekleeql qdldvalkkk eraerrkerl vyvgisieni ippqepdfse dqeekkkdsk
      961 kskanllerr strtrkcisy rfdefdeaid eaieddikea dgggvgrgkd istitghrgk
     1021 distildeer kenkrpqraa aarrkkrrrl ndldsdsnld eeesedefki sdgsqdefvv
     1081 sdenpdesee dppsnddsdt dfcsrrlrrh psrpmrqsrr lrrktpkkky sdddeeeese
     1141 ensrdsesdf sddfsddfve trrrrsrrnq krqinykeds esdgsqkslr rgkeirrvhk
     1201 rrlsssesee sylsknsedd elakeskrsv rkrgrstdey seadeeeeee egkpsrkrlh
     1261 rietdeeesc dnahgdanqp ardsqprvlp seqestkkpy riesdeeedf envgkvgspl
     1321 dyslvdlpst ngqspgkaie nligkpteks qtpkdnstas aslasngtsg gqeagapeee
     1381 edellrvtdl vdyvcnseql
//
LOCUS       XP_054225104             797 aa            linear   PRI 05-AUG-2025
DEFINITION  progesterone receptor isoform X1 [Homo sapiens].
ACCESSION   XP_054225104
VERSION     XP_054225104.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369129.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..797
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..797
                     /product="progesterone receptor isoform X1"
                     /calculated_mol_wt=82831
     Region          1..564
                     /region_name="Prog_receptor"
                     /note="Progesterone receptor; pfam02161"
                     /db_xref="CDD:460470"
     Region          563..640
                     /region_name="NR_DBD_GR_PR"
                     /note="DNA-binding domain of glucocorticoid receptor (GR)
                     is composed of two C4-type zinc fingers; cd07172"
                     /db_xref="CDD:143546"
     Site            order(567,570,584,587,603,609,619,622)
                     /site_type="other"
                     /note="zinc binding site [ion binding]"
                     /db_xref="CDD:143546"
     Site            order(577..579,585..586,588..589,592..593,601,616..617,
                     623)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143546"
     Site            order(602..604,606,609..610,614..615,618)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:143546"
     Region          686..>786
                     /region_name="NR_LBD"
                     /note="The ligand binding domain of nuclear receptors, a
                     family of ligand-activated transcription regulators;
                     cl11397"
                     /db_xref="CDD:472173"
     Site            order(718..719,722,725..726,755..756,759..760,763,766)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:132726"
     Site            order(727,730,734,739,744..745,747..748,751..752)
                     /site_type="active"
                     /note="coregulator recognition site [active]"
                     /db_xref="CDD:132726"
     CDS             1..797
                     /gene="PGR"
                     /gene_synonym="NR3C3; PR"
                     /coded_by="XM_054369129.1:745..3138"
                     /db_xref="GeneID:5241"
                     /db_xref="HGNC:HGNC:8910"
                     /db_xref="MIM:607311"
ORIGIN      
        1 mtelkakgpr aphvaggpps pevgspllcr paagpfpgsq tsdtlpevsa ipisldgllf
       61 prpcqgqdps dektqdqqsl sdvegaysra eatrgaggss ssppekdsgl ldsvldtlla
      121 psgpgqsqps ppacevtssw clfgpelped ppaapatqrv lsplmsrsgc kvgdssgtaa
      181 ahkvlprgls parqlllpas esphwsgapv kpspqaaave veeedgsese esagpllkgk
      241 pralggaaag ggaaavppga aaggvalvpk edsrfsaprv alveqdapma pgrsplattv
      301 mdfihvpilp lnhallaart rqlledesyd ggagaasafa pprsspcass tpvavgdfpd
      361 cayppdaepk ddayplysdf qppalkikee eegaeasars prsylvagan paafpdfplg
      421 pppplpprat psrpgeaavt aapasasvss asssgstlec ilykaegapp qqgpfapppc
      481 kapgasgcll prdglpstsa saaaagaapa lypalglngl pqlgyqaavl keglpqvypp
      541 ylnylrpdse asqspqysfe slpqkiclic gdeasgchyg vltcgsckvf fkramegqhn
      601 ylcagrndci vdkirrkncp acrlrkccqa gmvlggrkfk kfnkvrvvra ldavalpqpv
      661 gvpnesqals qrftfspgqd iqlipplinl lmsiepdviy aghdntkpdt ssslltslnq
      721 lgerqllsvv kwskslpgfr nlhiddqitl iqyswmslmv fglgwrsykh vsgqmlyfap
      781 dlilndsfgr atksnpv
//
LOCUS       XP_054225105             611 aa            linear   PRI 05-AUG-2025
DEFINITION  progesterone receptor isoform X2 [Homo sapiens].
ACCESSION   XP_054225105
VERSION     XP_054225105.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369130.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..611
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..611
                     /product="progesterone receptor isoform X2"
                     /calculated_mol_wt=62060
     Region          1..564
                     /region_name="Prog_receptor"
                     /note="Progesterone receptor; pfam02161"
                     /db_xref="CDD:460470"
     Region          563..>596
                     /region_name="NR_DBD_like"
                     /note="DNA-binding domain of nuclear receptors is composed
                     of two C4-type zinc fingers; cl02596"
                     /db_xref="CDD:413390"
     CDS             1..611
                     /gene="PGR"
                     /gene_synonym="NR3C3; PR"
                     /coded_by="XM_054369130.1:745..2580"
                     /db_xref="GeneID:5241"
                     /db_xref="HGNC:HGNC:8910"
                     /db_xref="MIM:607311"
ORIGIN      
        1 mtelkakgpr aphvaggpps pevgspllcr paagpfpgsq tsdtlpevsa ipisldgllf
       61 prpcqgqdps dektqdqqsl sdvegaysra eatrgaggss ssppekdsgl ldsvldtlla
      121 psgpgqsqps ppacevtssw clfgpelped ppaapatqrv lsplmsrsgc kvgdssgtaa
      181 ahkvlprgls parqlllpas esphwsgapv kpspqaaave veeedgsese esagpllkgk
      241 pralggaaag ggaaavppga aaggvalvpk edsrfsaprv alveqdapma pgrsplattv
      301 mdfihvpilp lnhallaart rqlledesyd ggagaasafa pprsspcass tpvavgdfpd
      361 cayppdaepk ddayplysdf qppalkikee eegaeasars prsylvagan paafpdfplg
      421 pppplpprat psrpgeaavt aapasasvss asssgstlec ilykaegapp qqgpfapppc
      481 kapgasgcll prdglpstsa saaaagaapa lypalglngl pqlgyqaavl keglpqvypp
      541 ylnylrpdse asqspqysfe slpqkiclic gdeasgchyg vltcgsckvf fkramedtci
      601 dptfksclcw d
//
LOCUS       XP_054225106            1686 aa            linear   PRI 05-AUG-2025
DEFINITION  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing
            subunit alpha isoform X1 [Homo sapiens].
ACCESSION   XP_054225106
VERSION     XP_054225106.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369131.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1686
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1686
                     /product="phosphatidylinositol 4-phosphate 3-kinase C2
                     domain-containing subunit alpha isoform X1"
                     /calculated_mol_wt=190549
     Region          409..512
                     /region_name="PI3K_rbd"
                     /note="PI3-kinase family, ras-binding domain; pfam00794"
                     /db_xref="CDD:395642"
     Region          677..849
                     /region_name="C2A_PI3K_class_II"
                     /note="C2 domain first repeat present in class II
                     phosphatidylinositol 3-kinases (PI3Ks); cd04012"
                     /db_xref="CDD:175979"
     Region          870..1038
                     /region_name="PI3Ka_II"
                     /note="Phosphoinositide 3-kinase (PI3K) class II,
                     accessory domain (PIK domain); PIK domain is conserved in
                     all PI3 and PI4-kinases. Its role is unclear but it has
                     been suggested to be involved in substrate presentation.
                     In general, class II PI3-kinases...; cd00869"
                     /db_xref="CDD:238441"
     Region          1043..1395
                     /region_name="PI3Kc_C2_alpha"
                     /note="Catalytic domain of Class II Phosphoinositide
                     3-kinase alpha; cd05176"
                     /db_xref="CDD:270720"
     Site            order(1112,1114..1116,1118,1136,1138,1141,1172,1184..1187,
                     1192,1195,1255,1257,1267..1268)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270720"
     Site            1247..1255
                     /site_type="active"
                     /note="catalytic loop [active]"
                     /db_xref="CDD:270720"
     Site            1268..1292
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270720"
     Region          1426..1534
                     /region_name="PX_PI3K_C2_alpha"
                     /note="The phosphoinositide binding Phox Homology Domain
                     of the Alpha Isoform of Class II Phosphoinositide
                     3-Kinases; cd07289"
                     /db_xref="CDD:132822"
     Site            order(1462..1464,1488..1489,1503)
                     /site_type="other"
                     /note="phosphoinositide binding site [chemical binding]"
                     /db_xref="CDD:132822"
     Region          1560..1681
                     /region_name="C2B_PI3K_class_II"
                     /note="C2 domain second repeat present in class II
                     phosphatidylinositol 3-kinases (PI3Ks); cd08381"
                     /db_xref="CDD:176027"
     Site            1609..1619
                     /site_type="active"
                     /note="nuclear localization signal [active]"
                     /db_xref="CDD:176027"
     CDS             1..1686
                     /gene="PIK3C2A"
                     /gene_synonym="CPK; OCSKD; PI3-K-C2(ALPHA); PI3-K-C2A;
                     PI3K-C2-alpha; PI3K-C2alpha"
                     /coded_by="XM_054369131.1:300..5360"
                     /db_xref="GeneID:5286"
                     /db_xref="HGNC:HGNC:8971"
                     /db_xref="MIM:603601"
ORIGIN      
        1 maqissnsgf kecpsshpep trakdvdkee alqmeaeala klqkdrqvtd nqrgfelsss
       61 trkkaqvynk qdydlmvfpe sdsqkraldi dvekltqael eklllddsfe tkktpvlpvt
      121 pilspsfsaq lyfrptiqrg qwppglpgps tyalpsiyps tyskqaafqn gfnprmptfp
      181 stepiylslp gqspyfsypl tpatpfhpqg slpiyrpvvs tdmaklfdki astseflkng
      241 kartdleitd skvsnlqvsp ksediskfdw ldldplskpk vdnvevldhe eeknvsslla
      301 kdpwdavlle erstanchle rkvngkslsv atvtrsqsln irttqlakaq ghisqkdpng
      361 tsslptgssl lqevevqnee maafcrsitk lktkfpytnh rtnpgyllsp vtaqrnicge
      421 nasvkvsidi egfqlpvtft cdvsstveii imqalcwvhd dlnqvdvgsy vlkvcgqeev
      481 lqnnhclgsh ehiqncrkwd teirlqlltf samcqnlart aeddetpvdl nkhlyqiekp
      541 ckeamtrhpv eelldsyhnq velalqienq hravdqvika vrkicsaldg vetlaitesv
      601 kklkravnlp rsktadvtsl fggedtsrss trgslnpenp vqvsinqlta aiydllrlha
      661 nsgrsptdca qssksvkeaw ttteqlqfti faahgissnw vsnyekyyli cslshngkdl
      721 fkpiqskkvg tyknffylik wdeliifpiq isqlplesvl hltlfgilnq ssgsspdsnk
      781 qrkgpealgk vslplfdfkr fltcgtklly lwtsshtnsv pgtvtkkgyv merivlqvdf
      841 pspafdiiyt tpqvdrsiiq qhnletlend ikgklldilh kdsslglske dkaflwekry
      901 ycfkhpnclp kilasapnwk wvnlaktysl lhqwpalypl ialelldskf adqevrslav
      961 twieaisdde ltdllpqfvq alkyeiylns slvqfllsra lgniqiahnl ywllkdalhd
     1021 vqfstryehv lgallsvggk rlreellkqt klvqllggva ekvrqasgsa rqvvlqrsme
     1081 rvqsffqknk crlplkpslv akelnikscs ffssnavplk vtmvnadpmg eeinvmfkvg
     1141 edlrqdmlal qmikimdkiw lkegldlrmv ifkclstgrd rgmvelvpas dtlrkiqvey
     1201 gvtgsfkdkp laewlrkynp seeeyekase nfiyscagcc vatyvlgicd rhndnimlrs
     1261 tghmfhidfg kflghaqmfg sfkrdrapfv ltsdmayvin ggekptirfq lfvdlccqay
     1321 nlirkqtnlf lnllslmips glpeltsiqd lkyvrdalqp qttdaeatif ftrliesslg
     1381 siatkfnffi hnlaqlrfsg lpsndepils fspktysfrq dgrikevsvf tyhkkynpdk
     1441 hyiyvvrilr egqiepsfvf rtfdefqelh nklsiifplw klpgfpnrmv lgrthikdva
     1501 akrkielnsy lqslmnastd vaecdlvctf fhpllrdeka egiarsadag sfsptpgqig
     1561 gavklsisyr ngtlfimvmh ikdlvtedga dpnpyvktyl lpdnhktskr ktkisrktrn
     1621 ptfnemlvys gysketlrqr elqlsvlsae slrenfflgg vtlplkdfnl sketvkwyql
     1681 taatyl
//
LOCUS       XP_054225107            1630 aa            linear   PRI 05-AUG-2025
DEFINITION  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing
            subunit alpha isoform X2 [Homo sapiens].
ACCESSION   XP_054225107
VERSION     XP_054225107.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369132.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1630
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1630
                     /product="phosphatidylinositol 4-phosphate 3-kinase C2
                     domain-containing subunit alpha isoform X2"
                     /calculated_mol_wt=184404
     Region          409..512
                     /region_name="PI3K_rbd"
                     /note="PI3-kinase family, ras-binding domain; pfam00794"
                     /db_xref="CDD:395642"
     Region          677..793
                     /region_name="C2A_PI3K_class_II"
                     /note="C2 domain first repeat present in class II
                     phosphatidylinositol 3-kinases (PI3Ks); cd04012"
                     /db_xref="CDD:175979"
     Region          814..982
                     /region_name="PI3Ka_II"
                     /note="Phosphoinositide 3-kinase (PI3K) class II,
                     accessory domain (PIK domain); PIK domain is conserved in
                     all PI3 and PI4-kinases. Its role is unclear but it has
                     been suggested to be involved in substrate presentation.
                     In general, class II PI3-kinases...; cd00869"
                     /db_xref="CDD:238441"
     Region          987..1339
                     /region_name="PI3Kc_C2_alpha"
                     /note="Catalytic domain of Class II Phosphoinositide
                     3-kinase alpha; cd05176"
                     /db_xref="CDD:270720"
     Site            order(1056,1058..1060,1062,1080,1082,1085,1116,1128..1131,
                     1136,1139,1199,1201,1211..1212)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270720"
     Site            1191..1199
                     /site_type="active"
                     /note="catalytic loop [active]"
                     /db_xref="CDD:270720"
     Site            1212..1236
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270720"
     Region          1370..1478
                     /region_name="PX_PI3K_C2_alpha"
                     /note="The phosphoinositide binding Phox Homology Domain
                     of the Alpha Isoform of Class II Phosphoinositide
                     3-Kinases; cd07289"
                     /db_xref="CDD:132822"
     Site            order(1406..1408,1432..1433,1447)
                     /site_type="other"
                     /note="phosphoinositide binding site [chemical binding]"
                     /db_xref="CDD:132822"
     Region          1504..1625
                     /region_name="C2B_PI3K_class_II"
                     /note="C2 domain second repeat present in class II
                     phosphatidylinositol 3-kinases (PI3Ks); cd08381"
                     /db_xref="CDD:176027"
     Site            1553..1563
                     /site_type="active"
                     /note="nuclear localization signal [active]"
                     /db_xref="CDD:176027"
     CDS             1..1630
                     /gene="PIK3C2A"
                     /gene_synonym="CPK; OCSKD; PI3-K-C2(ALPHA); PI3-K-C2A;
                     PI3K-C2-alpha; PI3K-C2alpha"
                     /coded_by="XM_054369132.1:274..5166"
                     /db_xref="GeneID:5286"
                     /db_xref="HGNC:HGNC:8971"
                     /db_xref="MIM:603601"
ORIGIN      
        1 maqissnsgf kecpsshpep trakdvdkee alqmeaeala klqkdrqvtd nqrgfelsss
       61 trkkaqvynk qdydlmvfpe sdsqkraldi dvekltqael eklllddsfe tkktpvlpvt
      121 pilspsfsaq lyfrptiqrg qwppglpgps tyalpsiyps tyskqaafqn gfnprmptfp
      181 stepiylslp gqspyfsypl tpatpfhpqg slpiyrpvvs tdmaklfdki astseflkng
      241 kartdleitd skvsnlqvsp ksediskfdw ldldplskpk vdnvevldhe eeknvsslla
      301 kdpwdavlle erstanchle rkvngkslsv atvtrsqsln irttqlakaq ghisqkdpng
      361 tsslptgssl lqevevqnee maafcrsitk lktkfpytnh rtnpgyllsp vtaqrnicge
      421 nasvkvsidi egfqlpvtft cdvsstveii imqalcwvhd dlnqvdvgsy vlkvcgqeev
      481 lqnnhclgsh ehiqncrkwd teirlqlltf samcqnlart aeddetpvdl nkhlyqiekp
      541 ckeamtrhpv eelldsyhnq velalqienq hravdqvika vrkicsaldg vetlaitesv
      601 kklkravnlp rsktadvtsl fggedtsrss trgslnpenp vqvsinqlta aiydllrlha
      661 nsgrsptdca qssksvkeaw ttteqlqfti faahgissnw vsnyekyyli cslshngkdl
      721 fkpiqskkvg tyknffylik wdelfltcgt kllylwtssh tnsvpgtvtk kgyvmerivl
      781 qvdfpspafd iiyttpqvdr siiqqhnlet lendikgkll dilhkdsslg lskedkaflw
      841 ekryycfkhp nclpkilasa pnwkwvnlak tysllhqwpa lyplialell dskfadqevr
      901 slavtwieai sddeltdllp qfvqalkyei ylnsslvqfl lsralgniqi ahnlywllkd
      961 alhdvqfstr yehvlgalls vggkrlreel lkqtklvqll ggvaekvrqa sgsarqvvlq
     1021 rsmervqsff qknkcrlplk pslvakelni kscsffssna vplkvtmvna dpmgeeinvm
     1081 fkvgedlrqd mlalqmikim dkiwlkegld lrmvifkcls tgrdrgmvel vpasdtlrki
     1141 qveygvtgsf kdkplaewlr kynpseeeye kasenfiysc agccvatyvl gicdrhndni
     1201 mlrstghmfh idfgkflgha qmfgsfkrdr apfvltsdma yvinggekpt irfqlfvdlc
     1261 cqaynlirkq tnlflnllsl mipsglpelt siqdlkyvrd alqpqttdae atifftrlie
     1321 sslgsiatkf nffihnlaql rfsglpsnde pilsfspkty sfrqdgrike vsvftyhkky
     1381 npdkhyiyvv rilregqiep sfvfrtfdef qelhnklsii fplwklpgfp nrmvlgrthi
     1441 kdvaakrkie lnsylqslmn astdvaecdl vctffhpllr dekaegiars adagsfsptp
     1501 gqiggavkls isyrngtlfi mvmhikdlvt edgadpnpyv ktyllpdnhk tskrktkisr
     1561 ktrnptfnem lvysgysket lrqrelqlsv lsaeslrenf flggvtlplk dfnlsketvk
     1621 wyqltaatyl
//
LOCUS       XP_054225108             703 aa            linear   PRI 05-AUG-2025
DEFINITION  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
            isoform X1 [Homo sapiens].
ACCESSION   XP_054225108
VERSION     XP_054225108.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369133.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..703
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..703
                     /product="1-phosphatidylinositol 4,5-bisphosphate
                     phosphodiesterase beta-3 isoform X1"
                     /calculated_mol_wt=78850
     Region          22..149
                     /region_name="PH_PLC_beta"
                     /note="Phospholipase C-beta (PLC-beta) pleckstrin homology
                     (PH) domain; cd13361"
                     /db_xref="CDD:270167"
     Site            order(27,29,40,57,123)
                     /site_type="other"
                     /note="Rac1 binding site [polypeptide binding]"
                     /db_xref="CDD:270167"
     Site            order(30,32,37,39,41,56..57)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:270167"
     Region          154..304
                     /region_name="EFh_PI-PLCbeta3"
                     /note="EF-hand motif found in phosphoinositide
                     phospholipase C beta 3 (PI-PLC-beta3); cd16210"
                     /db_xref="CDD:320040"
     Region          154..183
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320040"
     Region          187..216
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320040"
     Region          225..254
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320040"
     Site            257..263
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:320040"
     Region          271..304
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320040"
     Region          316..680
                     /region_name="PI-PLCc_beta"
                     /note="Catalytic domain of metazoan
                     phosphoinositide-specific phospholipase C-beta; cd08591"
                     /db_xref="CDD:176533"
     Site            order(332..333,362,364,379,413,466,468,619,646,648)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:176533"
     Site            order(332,379)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:176533"
     Site            order(333,362,364,413)
                     /site_type="other"
                     /note="Ca binding site [ion binding]"
                     /db_xref="CDD:176533"
     CDS             1..703
                     /gene="PLCB3"
                     /gene_synonym="SMDCD"
                     /coded_by="XM_054369133.1:121..2232"
                     /db_xref="GeneID:5331"
                     /db_xref="HGNC:HGNC:9056"
                     /db_xref="MIM:600230"
ORIGIN      
        1 magaqpgvha lqlepptvve tlrrgskfik wdeetssrnl vtlrvdpngf flywtgpnme
       61 vdtldissir dtrtgryarl pkdpkirevl gfggpdarle eklmtvvsgp dpvntvflnf
      121 mavqddtakv wseelfklam nilaqnasrn tflrkaytkl klqvnqdgri pvknilkmfs
      181 adkkrvetal escglkfnrs esirpdefsl eiferflnkl clrpdidkil leigakgkpy
      241 ltleqlmdfi nqkqrdprln evlypplrps qarlliekye pnqqflerdq msmegfsryl
      301 ggeengilpl ealdlstdmt qplsayfins shntyltagq lagtssvemy rqallwgcrc
      361 veldvwkgrp peeepfithg ftmttevplr dvleaiaeta fktspypvil sfenhvdsak
      421 qqakmaeycr sifgdallie pldkyplapg vplpspqdlm grilvknkkr hrpsaggpds
      481 agrkrpleqs nsalsessaa tepsspqlgs pssdscpgls ngeevglekp slepqkslgd
      541 eglnrgpyvl gpadredeee deeeeeqtdp kkpttdegta ssevnateem stlvnyiepv
      601 kfksfeaark rnkcfemssf vetkameqlt kspmefveyn kqqlsriypk gtrvdssnym
      661 pqlfwnvgcq lvalnfqtld prgtqlpthp ascpwlipdp spv
//
LOCUS       XP_054225109             151 aa            linear   PRI 05-AUG-2025
DEFINITION  sperm surface protein Sp17 isoform X1 [Homo sapiens].
ACCESSION   XP_054225109
VERSION     XP_054225109.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369134.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..151
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..151
                     /product="sperm surface protein Sp17 isoform X1"
                     /calculated_mol_wt=17275
     Region          9..50
                     /region_name="DD_CABYR_SP17"
                     /note="dimerization/docking (D/D) domain of the sperm
                     fibrous sheath proteins, Calcium-Binding
                     tYrosine-phosphorylation Regulated protein and Sperm
                     Protein 17; cd12100"
                     /db_xref="CDD:438521"
     Site            order(12,16..17,20..21,24..25,28..29)
                     /site_type="other"
                     /note="putative AKAP interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:438521"
     Site            order(16,19..20,23..24,27..28,31..32,34..37,39..40,43..44,
                     47)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:438521"
     Region          <117..138
                     /region_name="IQCD"
                     /note="IQ (isoleucine-glutamine) motif containing D
                     (IQCD); cd23767"
                     /db_xref="CDD:467745"
     CDS             1..151
                     /gene="SPA17"
                     /gene_synonym="CT22; SP17; SP17-1"
                     /coded_by="XM_054369134.1:328..783"
                     /db_xref="GeneID:53340"
                     /db_xref="HGNC:HGNC:11210"
                     /db_xref="MIM:608621"
ORIGIN      
        1 msipfsnthy ripqgfgnll egltreilre qpdnipafaa ayfesllekr ektnfdpaew
       61 gskvedrfyn nhafeeqepp eksdpkqees qisgkeeets vtildsseed kekeevaavk
      121 iqaafrghia reeakkmktn slqneekeen k
//
LOCUS       XP_054225110             151 aa            linear   PRI 05-AUG-2025
DEFINITION  sperm surface protein Sp17 isoform X1 [Homo sapiens].
ACCESSION   XP_054225110
VERSION     XP_054225110.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369135.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..151
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..151
                     /product="sperm surface protein Sp17 isoform X1"
                     /calculated_mol_wt=17275
     Region          9..50
                     /region_name="DD_CABYR_SP17"
                     /note="dimerization/docking (D/D) domain of the sperm
                     fibrous sheath proteins, Calcium-Binding
                     tYrosine-phosphorylation Regulated protein and Sperm
                     Protein 17; cd12100"
                     /db_xref="CDD:438521"
     Site            order(12,16..17,20..21,24..25,28..29)
                     /site_type="other"
                     /note="putative AKAP interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:438521"
     Site            order(16,19..20,23..24,27..28,31..32,34..37,39..40,43..44,
                     47)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:438521"
     Region          <117..138
                     /region_name="IQCD"
                     /note="IQ (isoleucine-glutamine) motif containing D
                     (IQCD); cd23767"
                     /db_xref="CDD:467745"
     CDS             1..151
                     /gene="SPA17"
                     /gene_synonym="CT22; SP17; SP17-1"
                     /coded_by="XM_054369135.1:191..646"
                     /db_xref="GeneID:53340"
                     /db_xref="HGNC:HGNC:11210"
                     /db_xref="MIM:608621"
ORIGIN      
        1 msipfsnthy ripqgfgnll egltreilre qpdnipafaa ayfesllekr ektnfdpaew
       61 gskvedrfyn nhafeeqepp eksdpkqees qisgkeeets vtildsseed kekeevaavk
      121 iqaafrghia reeakkmktn slqneekeen k
//
LOCUS       XP_054225111             449 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein C11orf24 isoform X1 [Homo sapiens].
ACCESSION   XP_054225111
VERSION     XP_054225111.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369136.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..449
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..449
                     /product="uncharacterized protein C11orf24 isoform X1"
                     /calculated_mol_wt=45970
     Region          1..449
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     CDS             1..449
                     /gene="C11orf24"
                     /gene_synonym="DM4E3"
                     /coded_by="XM_054369136.1:657..2006"
                     /db_xref="GeneID:53838"
                     /db_xref="HGNC:HGNC:1174"
                     /db_xref="MIM:610880"
ORIGIN      
        1 mwtalvliwi fslslsesha asndprnfvp nkmwkglvkr nasvetvdnk tsedvtmaaa
       61 spvtltkgts aahlnsmevt tedtsrtdvs epatsggaad gvtsiaptav assttaasit
      121 taassmtvas sapttaasst tvasiaptta assmtaasst pmtlalpapt ststgrtpst
      181 tatghpslst alaqvpkssa lprtatlatl atraqtvatt antsspmstr pspskhmpsd
      241 taaspvppmr pqaqgpisqv svdqpvvntt nkstpmpsnt tpepaptptv vtttkaqare
      301 ptaspvpvph tspipemeam spttqpspmp ytqraagpgt sqapeqvete atpgtdstgp
      361 tprssggtkm patdscqpst qgqymvvtte pltqavvdkt lllvvlllgv tlfitvlvlf
      421 alqayesykk kdytqvdyli ngmyadsem
//
LOCUS       XP_054225112             417 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein C11orf24 isoform X2 [Homo sapiens].
ACCESSION   XP_054225112
VERSION     XP_054225112.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369137.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..417
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..417
                     /product="uncharacterized protein C11orf24 isoform X2"
                     /calculated_mol_wt=42343
     Region          1..417
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     CDS             1..417
                     /gene="C11orf24"
                     /gene_synonym="DM4E3"
                     /coded_by="XM_054369137.1:132..1385"
                     /db_xref="GeneID:53838"
                     /db_xref="HGNC:HGNC:1174"
                     /db_xref="MIM:610880"
ORIGIN      
        1 mwkglvkrna svetvdnkts edvtmaaasp vtltkgtsaa hlnsmevtte dtsrtdvsep
       61 atsggaadgv tsiaptavas sttaasitta assmtvassa pttaassttv asiapttaas
      121 smtaasstpm tlalpaptst stgrtpstta tghpslstal aqvpkssalp rtatlatlat
      181 raqtvattan tsspmstrps pskhmpsdta aspvppmrpq aqgpisqvsv dqpvvnttnk
      241 stpmpsnttp epaptptvvt ttkaqarept aspvpvphts pipemeamsp ttqpspmpyt
      301 qraagpgtsq apeqveteat pgtdstgptp rssggtkmpa tdscqpstqg qymvvttepl
      361 tqavvdktll lvvlllgvtl fitvlvlfal qayesykkkd ytqvdyling myadsem
//
LOCUS       XP_054225114             765 aa            linear   PRI 05-AUG-2025
DEFINITION  cadherin-related family member 5 isoform X1 [Homo sapiens].
ACCESSION   XP_054225114
VERSION     XP_054225114.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369139.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..765
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..765
                     /product="cadherin-related family member 5 isoform X1"
                     /calculated_mol_wt=80487
     Region          37..120
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(41..42,85,87,116,118..119)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          274..343
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Region          <453..540
                     /region_name="PRK13700"
                     /note="conjugal transfer protein TraD; Provisional"
                     /db_xref="CDD:184256"
     Region          <456..656
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..765
                     /gene="CDHR5"
                     /gene_synonym="MLPCDH; MU-PCDH; MUCDHL; MUPCDH"
                     /coded_by="XM_054369139.1:54..2351"
                     /db_xref="GeneID:53841"
                     /db_xref="HGNC:HGNC:7521"
                     /db_xref="MIM:606839"
ORIGIN      
        1 mgswallwpp llftgllvrp pgtmaqaqyc svnkdifeve entnvteplv dihvpegqev
       61 tlgalstpfa friqgnqlfl nvtpdyeeks lleaqllcqs ggtlvtqlrv fvsvldvndn
      121 apefpfktke irveedtkvn stvipetqlq aedrdkddil fytlqemtag asdyfslvsv
      181 nrpalrldrp ldfyerpnmt fwllvrdtpg envepshtat atlvlnvvpa dlrppwflpc
      241 tfsdgyvciq aqyhgavptg hilpsplvlr pgpiyaedgd rginqpiiys ifrgnvngtf
      301 iihpdsgnlt varsvpspmt flllvkgqqa dlarysvtqv tveavaaags pprfpqrlyr
      361 gtvargagag vvvkdaaaps qplriqaqdp efsdlnsait yritnhshfr megevvlttt
      421 tlaqagafya eveahntvts gtattvieiq vseqeppsta qtpkpgtsqp mppgvgtsts
      481 hqpatpsggt aqtpepgtsq pmppsmgtst shqpatpggg taqtpeagts qpmppgmgts
      541 tshqpttpgg gtaqtpepgt sqpmplskst pssgggpsed krfsvvdmaa lggvlgalll
      601 lallgltvlv hkhygprlkc csgkapepqp qgfdnqaflp dhkanwapvp spthdpkpae
      661 apmpaepapp gpaspggape ppaaaraggs ptavrsiltk errpeggyka vwfgedigte
      721 advvvlnapt ldvdgasdsg sgdegegagr gggpydapgg ddsyi
//
LOCUS       XP_054225115             734 aa            linear   PRI 05-AUG-2025
DEFINITION  cadherin-related family member 5 isoform X2 [Homo sapiens].
ACCESSION   XP_054225115
VERSION     XP_054225115.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369140.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..734
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..734
                     /product="cadherin-related family member 5 isoform X2"
                     /calculated_mol_wt=77544
     Region          37..120
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(41..42,85,87,116,118..119)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          274..343
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Region          308..>541
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          <438..509
                     /region_name="PRK13700"
                     /note="conjugal transfer protein TraD; Provisional"
                     /db_xref="CDD:184256"
     CDS             1..734
                     /gene="CDHR5"
                     /gene_synonym="MLPCDH; MU-PCDH; MUCDHL; MUPCDH"
                     /coded_by="XM_054369140.1:54..2258"
                     /db_xref="GeneID:53841"
                     /db_xref="HGNC:HGNC:7521"
                     /db_xref="MIM:606839"
ORIGIN      
        1 mgswallwpp llftgllvrp pgtmaqaqyc svnkdifeve entnvteplv dihvpegqev
       61 tlgalstpfa friqgnqlfl nvtpdyeeks lleaqllcqs ggtlvtqlrv fvsvldvndn
      121 apefpfktke irveedtkvn stvipetqlq aedrdkddil fytlqemtag asdyfslvsv
      181 nrpalrldrp ldfyerpnmt fwllvrdtpg envepshtat atlvlnvvpa dlrppwflpc
      241 tfsdgyvciq aqyhgavptg hilpsplvlr pgpiyaedgd rginqpiiys ifrgnvngtf
      301 iihpdsgnlt varsvpspmt flllvkgqqa dlarysvtqv tveavaaags pprfpqrlyr
      361 gtvargagag vvvkdaaaps qplriqaqdp efsdlnsait yritnhshfr megevvlttt
      421 tlaqagafya eveahntvts gtattvieiq vseqeppsta qtpepgtsqp mppsmgtsts
      481 hqpatpgggt aqtpeagtsq pmppgmgtst shqpttpggg taqtpepgts qpmplskstp
      541 ssgggpsedk rfsvvdmaal ggvlgallll allgltvlvh khygprlkcc sgkapepqpq
      601 gfdnqaflpd hkanwapvps pthdpkpaea pmpaepappg paspggapep paaaraggsp
      661 tavrsiltke rrpeggykav wfgedigtea dvvvlnaptl dvdgasdsgs gdegegagrg
      721 ggpydapggd dsyi
//
LOCUS       XP_054225116             703 aa            linear   PRI 05-AUG-2025
DEFINITION  cadherin-related family member 5 isoform X3 [Homo sapiens].
ACCESSION   XP_054225116
VERSION     XP_054225116.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369141.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..703
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..703
                     /product="cadherin-related family member 5 isoform X3"
                     /calculated_mol_wt=74569
     Region          37..120
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(41..42,85,87,116,118..119)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          274..343
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Region          <417..515
                     /region_name="PRK12438"
                     /note="hypothetical protein; Provisional"
                     /db_xref="CDD:171499"
     CDS             1..703
                     /gene="CDHR5"
                     /gene_synonym="MLPCDH; MU-PCDH; MUCDHL; MUPCDH"
                     /coded_by="XM_054369141.1:54..2165"
                     /db_xref="GeneID:53841"
                     /db_xref="HGNC:HGNC:7521"
                     /db_xref="MIM:606839"
ORIGIN      
        1 mgswallwpp llftgllvrp pgtmaqaqyc svnkdifeve entnvteplv dihvpegqev
       61 tlgalstpfa friqgnqlfl nvtpdyeeks lleaqllcqs ggtlvtqlrv fvsvldvndn
      121 apefpfktke irveedtkvn stvipetqlq aedrdkddil fytlqemtag asdyfslvsv
      181 nrpalrldrp ldfyerpnmt fwllvrdtpg envepshtat atlvlnvvpa dlrppwflpc
      241 tfsdgyvciq aqyhgavptg hilpsplvlr pgpiyaedgd rginqpiiys ifrgnvngtf
      301 iihpdsgnlt varsvpspmt flllvkgqqa dlarysvtqv tveavaaags pprfpqrlyr
      361 gtvargagag vvvkdaaaps qplriqaqdp efsdlnsait yritnhshfr megevvlttt
      421 tlaqagafya eveahntvts gtattvieiq vseqeppsta qtpeagtsqp mppgmgtsts
      481 hqpttpgggt aqtpepgtsq pmplskstps sgggpsedkr fsvvdmaalg gvlgalllla
      541 llgltvlvhk hygprlkccs gkapepqpqg fdnqaflpdh kanwapvpsp thdpkpaeap
      601 mpaepappgp aspggapepp aaaraggspt avrsiltker rpeggykavw fgedigtead
      661 vvvlnaptld vdgasdsgsg degegagrgg gpydapggdd syi
//
LOCUS       XP_054225117             680 aa            linear   PRI 05-AUG-2025
DEFINITION  cadherin-related family member 5 isoform X4 [Homo sapiens].
ACCESSION   XP_054225117
VERSION     XP_054225117.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369142.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..680
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..680
                     /product="cadherin-related family member 5 isoform X4"
                     /calculated_mol_wt=71666
     Region          37..120
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(41..42,85,87,116,118..119)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          274..343
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Region          <452..665
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..680
                     /gene="CDHR5"
                     /gene_synonym="MLPCDH; MU-PCDH; MUCDHL; MUPCDH"
                     /coded_by="XM_054369142.1:54..2096"
                     /db_xref="GeneID:53841"
                     /db_xref="HGNC:HGNC:7521"
                     /db_xref="MIM:606839"
ORIGIN      
        1 mgswallwpp llftgllvrp pgtmaqaqyc svnkdifeve entnvteplv dihvpegqev
       61 tlgalstpfa friqgnqlfl nvtpdyeeks lleaqllcqs ggtlvtqlrv fvsvldvndn
      121 apefpfktke irveedtkvn stvipetqlq aedrdkddil fytlqemtag asdyfslvsv
      181 nrpalrldrp ldfyerpnmt fwllvrdtpg envepshtat atlvlnvvpa dlrppwflpc
      241 tfsdgyvciq aqyhgavptg hilpsplvlr pgpiyaedgd rginqpiiys ifrgnvngtf
      301 iihpdsgnlt varsvpspmt flllvkgqqa dlarysvtqv tveavaaags pprfpqrlyr
      361 gtvargagag vvvkdaaaps qplriqaqdp efsdlnsait yritnhshfr megevvlttt
      421 tlaqagafya eveahntvts gtattvieiq vseqeppstd vppspeaggt tgpwtsttse
      481 vprppepsqg psttssgggt gphppsgttl rpptsstpgg ppgaenstsh qpatpggdta
      541 qtpkpgtsqp mppgvgtsts hqpatpsggt aqtpepgtsq pmppsmgtst shqpatpggg
      601 taqtpeagts qpmppgmgts tshqpttpgg gtaqtpepgt sqpmplskst pssgqrpdvg
      661 sseshdshgc rspckslhll
//
LOCUS       XP_054225118             551 aa            linear   PRI 05-AUG-2025
DEFINITION  cadherin-related family member 5 isoform X5 [Homo sapiens].
ACCESSION   XP_054225118
VERSION     XP_054225118.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369143.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..551
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..551
                     /product="cadherin-related family member 5 isoform X5"
                     /calculated_mol_wt=60386
     Region          37..120
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(41..42,85,87,116,118..119)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          110..>165
                     /region_name="Cadherin_3"
                     /note="Cadherin-like; pfam16184"
                     /db_xref="CDD:465048"
     Region          150..228
                     /region_name="CA_like"
                     /note="Cadherin repeat-like domain; cl46864"
                     /db_xref="CDD:481204"
     Region          274..343
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Region          <463..>549
                     /region_name="PRK12323"
                     /note="DNA polymerase III subunit gamma/tau; cl46901"
                     /db_xref="CDD:481241"
     CDS             1..551
                     /gene="CDHR5"
                     /gene_synonym="MLPCDH; MU-PCDH; MUCDHL; MUPCDH"
                     /coded_by="XM_054369143.1:54..1709"
                     /db_xref="GeneID:53841"
                     /db_xref="HGNC:HGNC:7521"
                     /db_xref="MIM:606839"
ORIGIN      
        1 mgswallwpp llftgllvrp pgtmaqaqyc svnkdifeve entnvteplv dihvpegqev
       61 tlgalstpfa friqgnqlfl nvtpdyeeks lleaqllcqs ggtlvtqlrv fvsvldvndn
      121 apefpfktke irveedtkvn stvipetqlq aedrdkddil fytlqemtag asdyfslvsv
      181 nrpalrldrp ldfyerpnmt fwllvrdtpg envepshtat atlvlnvvpa dlrppwflpc
      241 tfsdgyvciq aqyhgavptg hilpsplvlr pgpiyaedgd rginqpiiys ifrgnvngtf
      301 iihpdsgnlt varsvpspmt flllvkgqqa dlarysvtqv tveavaaags pprfpqrlyr
      361 gtvargagag vvvkdaaaps qplriqaqdp efsdlnsait yritnhshfr megevvlttt
      421 tlaqagafya evaaprrtsa srwwiwrpwa gcwvrcccwl slaspslsts tmapgssaal
      481 aklrspspka lttrrssltt rptgrpspap rttpsprrhr cpqsphppal ppqavplspp
      541 qrpelaeapr r
//
LOCUS       XP_054225119            1100 aa            linear   PRI 05-AUG-2025
DEFINITION  contactin-5 isoform X1 [Homo sapiens].
ACCESSION   XP_054225119
VERSION     XP_054225119.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369144.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1100
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1100
                     /product="contactin-5 isoform X1"
                     /calculated_mol_wt=120542
     Region          98..193
                     /region_name="IgI_1_Contactin-5"
                     /note="First immunoglobulin (Ig) domain of contactin-5;
                     member of the I-set of Ig superfamily domains; cd05848"
                     /db_xref="CDD:409435"
     Site            order(98..99,180..183)
                     /site_type="other"
                     /note="interdomain interface [polypeptide binding]"
                     /db_xref="CDD:409435"
     Region          100..104
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409435"
     Region          107..112
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409435"
     Region          118..126
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409435"
     Region          131..137
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409435"
     Region          139..142
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409435"
     Region          149..153
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409435"
     Region          155..161
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409435"
     Region          168..177
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409435"
     Region          180..193
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409435"
     Region          202..287
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          213..217
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          227..231
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          252..256
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          266..271
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          282..285
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          300..387
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          318..322
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          331..335
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          352..356
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          366..371
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          379..382
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          392..475
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          407..411
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          420..424
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          441..445
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          455..460
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          468..471
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          480..568
                     /region_name="Ig5_Contactin"
                     /note="Fifth immunoglobulin (Ig) domain of contactin;
                     cd04969"
                     /db_xref="CDD:409358"
     Region          480..485
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409358"
     Region          488..493
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409358"
     Region          497..504
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409358"
     Region          512..516
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409358"
     Region          530..533
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409358"
     Region          534..539
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409358"
     Region          547..555
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409358"
     Region          561..568
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409358"
     Region          570..671
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          589..593
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          604..608
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          633..637
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          647..652
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          660..663
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          671..768
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(671,740,755)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          <718..>1023
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     Site            order(756..757,759..760)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          878..969
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(958..959,961..962)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     CDS             1..1100
                     /gene="CNTN5"
                     /gene_synonym="HNB-2s; NB-2"
                     /coded_by="XM_054369144.1:628..3930"
                     /db_xref="GeneID:53942"
                     /db_xref="HGNC:HGNC:2175"
                     /db_xref="MIM:607219"
ORIGIN      
        1 masswklmlf lsvtmclsey skslpglsts yaallrikks sssslfgskt rprysspslg
       61 tlsasspswl gaaqnyyspi nlyhssdafk qdesvdygpv fvqepddiif ptdsdekkva
      121 lncevrgnpv psyrwlrngt eidlesdyry slidgtfiis npseakdsgh yqclatntvg
      181 silsreatlq faylgnfsgr trsavsvreg qgvvlmcspp phspeiiysw vfnefpsfva
      241 edsrrfisqe tgnlyiskvq tsdvgsyicl vkntvtnarv lspptpltlr ndgvmgeyep
      301 kievhfpftv taakgttvkm ecfalgnpvp titwmkvngy ipskarlrks qavleipnvq
      361 lddagiyecr aensrgknsf rgqlqvytyp hwveklndtq ldsgsplrwe ckatgkprpt
      421 yrwlkngvpl spqsrvemvn gvlmihnvnq sdagmyqcla enkygaiyas aelkilasap
      481 tfalnqlkkt iivtkdqevv ieckpqgspk ptiswkkgdr avrenkriav lpdgslriln
      541 asksdegkyv crgenvfgsa eiiaslsvke ptrieltpkr teltvgesiv lnckaihdas
      601 ldvtfywtlk gqpidfeeeg ghfesiraqa ssadlmirni llmhagrygc rvqttadsvs
      661 deaellvrgp pgppgivive eitestatls wspaadnhsp issynlqars pfslgwqtvk
      721 tvpeiitgdm esamavdlnp wveyefrvva tnpigtgdps tpsrmirtne avpktaptnv
      781 sgrsgrrhel viawepvsee fqngegfgyi vafrpngtrg wkekmvtsse askfiyrdes
      841 vppltpfevk vgvynnkgdg pfsqivvics aegepsaapt dvkatsvsvs eilvawkhik
      901 eslgrpqgfe vgywkdmeqe dtaetvktrg nesfviltgl egntlyhftv rayngagygp
      961 pssevsattk ksppsqapsn lrweqqgsqv slgwepvipl anesevvgyk vfyrqeghsn
     1021 sqvietqklq avvplpdagv yiievrayse ggdgtassqi rvpsysggki tsaqstlhsl
     1081 stssssvtll lalmipstsw
//
LOCUS       XP_054225120            1026 aa            linear   PRI 05-AUG-2025
DEFINITION  contactin-5 isoform X2 [Homo sapiens].
ACCESSION   XP_054225120
VERSION     XP_054225120.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369145.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1026
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1026
                     /product="contactin-5 isoform X2"
                     /calculated_mol_wt=112562
     Region          24..119
                     /region_name="IgI_1_Contactin-5"
                     /note="First immunoglobulin (Ig) domain of contactin-5;
                     member of the I-set of Ig superfamily domains; cd05848"
                     /db_xref="CDD:409435"
     Site            order(24..25,106..109)
                     /site_type="other"
                     /note="interdomain interface [polypeptide binding]"
                     /db_xref="CDD:409435"
     Region          26..30
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409435"
     Region          33..38
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409435"
     Region          44..52
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409435"
     Region          57..63
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409435"
     Region          65..68
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409435"
     Region          75..79
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409435"
     Region          81..87
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409435"
     Region          94..103
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409435"
     Region          106..119
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409435"
     Region          128..213
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          139..143
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409392"
     Region          153..157
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409392"
     Region          178..182
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409392"
     Region          192..197
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409392"
     Region          208..211
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409392"
     Region          226..313
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          244..248
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409357"
     Region          257..261
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409357"
     Region          278..282
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409357"
     Region          292..297
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409357"
     Region          305..308
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409357"
     Region          318..401
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          333..337
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          346..350
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          367..371
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          381..386
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          394..397
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          406..494
                     /region_name="Ig5_Contactin"
                     /note="Fifth immunoglobulin (Ig) domain of contactin;
                     cd04969"
                     /db_xref="CDD:409358"
     Region          406..411
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409358"
     Region          414..419
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409358"
     Region          423..430
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409358"
     Region          438..442
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409358"
     Region          456..459
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409358"
     Region          460..465
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409358"
     Region          473..481
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409358"
     Region          487..494
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409358"
     Region          496..597
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          515..519
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409359"
     Region          530..534
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409359"
     Region          559..563
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409359"
     Region          573..578
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409359"
     Region          586..589
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409359"
     Region          597..694
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(597,666,681)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          <644..>949
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     Site            order(682..683,685..686)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     CDS             1..1026
                     /gene="CNTN5"
                     /gene_synonym="HNB-2s; NB-2"
                     /coded_by="XM_054369145.1:532..3612"
                     /db_xref="GeneID:53942"
                     /db_xref="HGNC:HGNC:2175"
                     /db_xref="MIM:607219"
ORIGIN      
        1 masswklmlf lsvtmclses vdygpvfvqe pddiifptds dekkvalnce vrgnpvpsyr
       61 wlrngteidl esdyryslid gtfiisnpse akdsghyqcl atntvgsils reatlqfayl
      121 gnfsgrtrsa vsvregqgvv lmcsppphsp eiiyswvfne fpsfvaedsr rfisqetgnl
      181 yiskvqtsdv gsyiclvknt vtnarvlspp tpltlrndgv mgeyepkiev hfpftvtaak
      241 gttvkmecfa lgnpvptitw mkvngyipsk arlrksqavl eipnvqldda giyecraens
      301 rgknsfrgql qvytyphwve klndtqldsg splrweckat gkprptyrwl kngvplspqs
      361 rvemvngvlm ihnvnqsdag myqclaenky gaiyasaelk ilasaptfal nqlkktiivt
      421 kdqevvieck pqgspkptis wkkgdravre nkriavlpdg slrilnasks degkyvcrge
      481 nvfgsaeiia slsvkeptri eltpkrtelt vgesivlnck aihdasldvt fywtlkgqpi
      541 dfeeegghfe siraqassad lmirnillmh agrygcrvqt tadsvsdeae llvrgppgpp
      601 giviveeite statlswspa adnhspissy nlqarspfsl gwqtvktvpe iitgdmesam
      661 avdlnpwvey efrvvatnpi gtgdpstpsr mirtneavpk taptnvsgrs grrhelviaw
      721 epvseefqng egfgyivafr pngtrgwkek mvtsseaskf iyrdesvppl tpfevkvgvy
      781 nnkgdgpfsq ivvicsaege psaaptdvka tsvsvseilv awkhikeslg rpqgfevgyw
      841 kdmeqedtae tvktrgnesf viltglegnt lyhftvrayn gagygppsse vsattkkspp
      901 sqapsnlrwe qqgsqvslgw epviplanes evvgykvfyr qeghsnsqvi etqklqavvp
      961 lpdagvyiie vrayseggdg tassqirvps ysggkitsaq stlhslstss ssvtlllalm
     1021 ipstsw
//
LOCUS       XP_054225121            1026 aa            linear   PRI 05-AUG-2025
DEFINITION  contactin-5 isoform X2 [Homo sapiens].
ACCESSION   XP_054225121
VERSION     XP_054225121.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369146.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1026
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1026
                     /product="contactin-5 isoform X2"
                     /calculated_mol_wt=112562
     Region          24..119
                     /region_name="IgI_1_Contactin-5"
                     /note="First immunoglobulin (Ig) domain of contactin-5;
                     member of the I-set of Ig superfamily domains; cd05848"
                     /db_xref="CDD:409435"
     Site            order(24..25,106..109)
                     /site_type="other"
                     /note="interdomain interface [polypeptide binding]"
                     /db_xref="CDD:409435"
     Region          26..30
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409435"
     Region          33..38
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409435"
     Region          44..52
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409435"
     Region          57..63
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409435"
     Region          65..68
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409435"
     Region          75..79
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409435"
     Region          81..87
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409435"
     Region          94..103
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409435"
     Region          106..119
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409435"
     Region          128..213
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          139..143
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409392"
     Region          153..157
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409392"
     Region          178..182
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409392"
     Region          192..197
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409392"
     Region          208..211
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409392"
     Region          226..313
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          244..248
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409357"
     Region          257..261
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409357"
     Region          278..282
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409357"
     Region          292..297
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409357"
     Region          305..308
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409357"
     Region          318..401
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          333..337
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          346..350
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          367..371
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          381..386
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          394..397
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          406..494
                     /region_name="Ig5_Contactin"
                     /note="Fifth immunoglobulin (Ig) domain of contactin;
                     cd04969"
                     /db_xref="CDD:409358"
     Region          406..411
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409358"
     Region          414..419
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409358"
     Region          423..430
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409358"
     Region          438..442
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409358"
     Region          456..459
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409358"
     Region          460..465
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409358"
     Region          473..481
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409358"
     Region          487..494
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409358"
     Region          496..597
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          515..519
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409359"
     Region          530..534
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409359"
     Region          559..563
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409359"
     Region          573..578
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409359"
     Region          586..589
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409359"
     Region          597..694
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(597,666,681)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          <644..>949
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     Site            order(682..683,685..686)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     CDS             1..1026
                     /gene="CNTN5"
                     /gene_synonym="HNB-2s; NB-2"
                     /coded_by="XM_054369146.1:393..3473"
                     /db_xref="GeneID:53942"
                     /db_xref="HGNC:HGNC:2175"
                     /db_xref="MIM:607219"
ORIGIN      
        1 masswklmlf lsvtmclses vdygpvfvqe pddiifptds dekkvalnce vrgnpvpsyr
       61 wlrngteidl esdyryslid gtfiisnpse akdsghyqcl atntvgsils reatlqfayl
      121 gnfsgrtrsa vsvregqgvv lmcsppphsp eiiyswvfne fpsfvaedsr rfisqetgnl
      181 yiskvqtsdv gsyiclvknt vtnarvlspp tpltlrndgv mgeyepkiev hfpftvtaak
      241 gttvkmecfa lgnpvptitw mkvngyipsk arlrksqavl eipnvqldda giyecraens
      301 rgknsfrgql qvytyphwve klndtqldsg splrweckat gkprptyrwl kngvplspqs
      361 rvemvngvlm ihnvnqsdag myqclaenky gaiyasaelk ilasaptfal nqlkktiivt
      421 kdqevvieck pqgspkptis wkkgdravre nkriavlpdg slrilnasks degkyvcrge
      481 nvfgsaeiia slsvkeptri eltpkrtelt vgesivlnck aihdasldvt fywtlkgqpi
      541 dfeeegghfe siraqassad lmirnillmh agrygcrvqt tadsvsdeae llvrgppgpp
      601 giviveeite statlswspa adnhspissy nlqarspfsl gwqtvktvpe iitgdmesam
      661 avdlnpwvey efrvvatnpi gtgdpstpsr mirtneavpk taptnvsgrs grrhelviaw
      721 epvseefqng egfgyivafr pngtrgwkek mvtsseaskf iyrdesvppl tpfevkvgvy
      781 nnkgdgpfsq ivvicsaege psaaptdvka tsvsvseilv awkhikeslg rpqgfevgyw
      841 kdmeqedtae tvktrgnesf viltglegnt lyhftvrayn gagygppsse vsattkkspp
      901 sqapsnlrwe qqgsqvslgw epviplanes evvgykvfyr qeghsnsqvi etqklqavvp
      961 lpdagvyiie vrayseggdg tassqirvps ysggkitsaq stlhslstss ssvtlllalm
     1021 ipstsw
//
LOCUS       XP_054225122             647 aa            linear   PRI 05-AUG-2025
DEFINITION  contactin-5 isoform X3 [Homo sapiens].
ACCESSION   XP_054225122
VERSION     XP_054225122.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369147.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..647
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..647
                     /product="contactin-5 isoform X3"
                     /calculated_mol_wt=71762
     Region          98..193
                     /region_name="IgI_1_Contactin-5"
                     /note="First immunoglobulin (Ig) domain of contactin-5;
                     member of the I-set of Ig superfamily domains; cd05848"
                     /db_xref="CDD:409435"
     Site            order(98..99,180..183)
                     /site_type="other"
                     /note="interdomain interface [polypeptide binding]"
                     /db_xref="CDD:409435"
     Region          100..104
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409435"
     Region          107..112
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409435"
     Region          118..126
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409435"
     Region          131..137
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409435"
     Region          139..142
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409435"
     Region          149..153
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409435"
     Region          155..161
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409435"
     Region          168..177
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409435"
     Region          180..193
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409435"
     Region          202..287
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          213..217
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409392"
     Region          227..231
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409392"
     Region          252..256
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409392"
     Region          266..271
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409392"
     Region          282..285
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409392"
     Region          300..387
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          318..322
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409357"
     Region          331..335
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409357"
     Region          352..356
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409357"
     Region          366..371
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409357"
     Region          379..382
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409357"
     Region          392..475
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          407..411
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          420..424
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          441..445
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          455..460
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          468..471
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          480..568
                     /region_name="Ig5_Contactin"
                     /note="Fifth immunoglobulin (Ig) domain of contactin;
                     cd04969"
                     /db_xref="CDD:409358"
     Region          480..485
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409358"
     Region          488..493
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409358"
     Region          497..504
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409358"
     Region          512..516
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409358"
     Region          530..533
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409358"
     Region          534..539
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409358"
     Region          547..555
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409358"
     Region          561..568
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409358"
     Region          570..>624
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          589..593
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409359"
     Region          604..608
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409359"
     CDS             1..647
                     /gene="CNTN5"
                     /gene_synonym="HNB-2s; NB-2"
                     /coded_by="XM_054369147.1:532..2475"
                     /db_xref="GeneID:53942"
                     /db_xref="HGNC:HGNC:2175"
                     /db_xref="MIM:607219"
ORIGIN      
        1 masswklmlf lsvtmclsey skslpglsts yaallrikks sssslfgskt rprysspslg
       61 tlsasspswl gaaqnyyspi nlyhssdafk qdesvdygpv fvqepddiif ptdsdekkva
      121 lncevrgnpv psyrwlrngt eidlesdyry slidgtfiis npseakdsgh yqclatntvg
      181 silsreatlq faylgnfsgr trsavsvreg qgvvlmcspp phspeiiysw vfnefpsfva
      241 edsrrfisqe tgnlyiskvq tsdvgsyicl vkntvtnarv lspptpltlr ndgvmgeyep
      301 kievhfpftv taakgttvkm ecfalgnpvp titwmkvngy ipskarlrks qavleipnvq
      361 lddagiyecr aensrgknsf rgqlqvytyp hwveklndtq ldsgsplrwe ckatgkprpt
      421 yrwlkngvpl spqsrvemvn gvlmihnvnq sdagmyqcla enkygaiyas aelkilasap
      481 tfalnqlkkt iivtkdqevv ieckpqgspk ptiswkkgdr avrenkriav lpdgslriln
      541 asksdegkyv crgenvfgsa eiiaslsvke ptrieltpkr teltvgesiv lnckaihdas
      601 ldvtfywtlk gqpidfeeeg ghfesiravl fhwipvttll vsqviyk
//
LOCUS       XP_054225123             647 aa            linear   PRI 05-AUG-2025
DEFINITION  contactin-5 isoform X3 [Homo sapiens].
ACCESSION   XP_054225123
VERSION     XP_054225123.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369148.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..647
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..647
                     /product="contactin-5 isoform X3"
                     /calculated_mol_wt=71762
     Region          98..193
                     /region_name="IgI_1_Contactin-5"
                     /note="First immunoglobulin (Ig) domain of contactin-5;
                     member of the I-set of Ig superfamily domains; cd05848"
                     /db_xref="CDD:409435"
     Site            order(98..99,180..183)
                     /site_type="other"
                     /note="interdomain interface [polypeptide binding]"
                     /db_xref="CDD:409435"
     Region          100..104
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409435"
     Region          107..112
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409435"
     Region          118..126
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409435"
     Region          131..137
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409435"
     Region          139..142
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409435"
     Region          149..153
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409435"
     Region          155..161
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409435"
     Region          168..177
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409435"
     Region          180..193
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409435"
     Region          202..287
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          213..217
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409392"
     Region          227..231
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409392"
     Region          252..256
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409392"
     Region          266..271
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409392"
     Region          282..285
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409392"
     Region          300..387
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          318..322
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409357"
     Region          331..335
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409357"
     Region          352..356
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409357"
     Region          366..371
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409357"
     Region          379..382
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409357"
     Region          392..475
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          407..411
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          420..424
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          441..445
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          455..460
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          468..471
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          480..568
                     /region_name="Ig5_Contactin"
                     /note="Fifth immunoglobulin (Ig) domain of contactin;
                     cd04969"
                     /db_xref="CDD:409358"
     Region          480..485
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409358"
     Region          488..493
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409358"
     Region          497..504
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409358"
     Region          512..516
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409358"
     Region          530..533
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409358"
     Region          534..539
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409358"
     Region          547..555
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409358"
     Region          561..568
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409358"
     Region          570..>624
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          589..593
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409359"
     Region          604..608
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409359"
     CDS             1..647
                     /gene="CNTN5"
                     /gene_synonym="HNB-2s; NB-2"
                     /coded_by="XM_054369148.1:628..2571"
                     /db_xref="GeneID:53942"
                     /db_xref="HGNC:HGNC:2175"
                     /db_xref="MIM:607219"
ORIGIN      
        1 masswklmlf lsvtmclsey skslpglsts yaallrikks sssslfgskt rprysspslg
       61 tlsasspswl gaaqnyyspi nlyhssdafk qdesvdygpv fvqepddiif ptdsdekkva
      121 lncevrgnpv psyrwlrngt eidlesdyry slidgtfiis npseakdsgh yqclatntvg
      181 silsreatlq faylgnfsgr trsavsvreg qgvvlmcspp phspeiiysw vfnefpsfva
      241 edsrrfisqe tgnlyiskvq tsdvgsyicl vkntvtnarv lspptpltlr ndgvmgeyep
      301 kievhfpftv taakgttvkm ecfalgnpvp titwmkvngy ipskarlrks qavleipnvq
      361 lddagiyecr aensrgknsf rgqlqvytyp hwveklndtq ldsgsplrwe ckatgkprpt
      421 yrwlkngvpl spqsrvemvn gvlmihnvnq sdagmyqcla enkygaiyas aelkilasap
      481 tfalnqlkkt iivtkdqevv ieckpqgspk ptiswkkgdr avrenkriav lpdgslriln
      541 asksdegkyv crgenvfgsa eiiaslsvke ptrieltpkr teltvgesiv lnckaihdas
      601 ldvtfywtlk gqpidfeeeg ghfesiravl fhwipvttll vsqviyk
//
LOCUS       XP_054225124             647 aa            linear   PRI 05-AUG-2025
DEFINITION  contactin-5 isoform X3 [Homo sapiens].
ACCESSION   XP_054225124
VERSION     XP_054225124.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369149.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..647
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..647
                     /product="contactin-5 isoform X3"
                     /calculated_mol_wt=71762
     Region          98..193
                     /region_name="IgI_1_Contactin-5"
                     /note="First immunoglobulin (Ig) domain of contactin-5;
                     member of the I-set of Ig superfamily domains; cd05848"
                     /db_xref="CDD:409435"
     Site            order(98..99,180..183)
                     /site_type="other"
                     /note="interdomain interface [polypeptide binding]"
                     /db_xref="CDD:409435"
     Region          100..104
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409435"
     Region          107..112
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409435"
     Region          118..126
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409435"
     Region          131..137
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409435"
     Region          139..142
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409435"
     Region          149..153
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409435"
     Region          155..161
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409435"
     Region          168..177
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409435"
     Region          180..193
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409435"
     Region          202..287
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          213..217
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409392"
     Region          227..231
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409392"
     Region          252..256
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409392"
     Region          266..271
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409392"
     Region          282..285
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409392"
     Region          300..387
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          318..322
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409357"
     Region          331..335
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409357"
     Region          352..356
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409357"
     Region          366..371
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409357"
     Region          379..382
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409357"
     Region          392..475
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          407..411
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          420..424
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          441..445
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          455..460
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          468..471
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          480..568
                     /region_name="Ig5_Contactin"
                     /note="Fifth immunoglobulin (Ig) domain of contactin;
                     cd04969"
                     /db_xref="CDD:409358"
     Region          480..485
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409358"
     Region          488..493
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409358"
     Region          497..504
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409358"
     Region          512..516
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409358"
     Region          530..533
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409358"
     Region          534..539
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409358"
     Region          547..555
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409358"
     Region          561..568
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409358"
     Region          570..>624
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          589..593
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409359"
     Region          604..608
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409359"
     CDS             1..647
                     /gene="CNTN5"
                     /gene_synonym="HNB-2s; NB-2"
                     /coded_by="XM_054369149.1:393..2336"
                     /db_xref="GeneID:53942"
                     /db_xref="HGNC:HGNC:2175"
                     /db_xref="MIM:607219"
ORIGIN      
        1 masswklmlf lsvtmclsey skslpglsts yaallrikks sssslfgskt rprysspslg
       61 tlsasspswl gaaqnyyspi nlyhssdafk qdesvdygpv fvqepddiif ptdsdekkva
      121 lncevrgnpv psyrwlrngt eidlesdyry slidgtfiis npseakdsgh yqclatntvg
      181 silsreatlq faylgnfsgr trsavsvreg qgvvlmcspp phspeiiysw vfnefpsfva
      241 edsrrfisqe tgnlyiskvq tsdvgsyicl vkntvtnarv lspptpltlr ndgvmgeyep
      301 kievhfpftv taakgttvkm ecfalgnpvp titwmkvngy ipskarlrks qavleipnvq
      361 lddagiyecr aensrgknsf rgqlqvytyp hwveklndtq ldsgsplrwe ckatgkprpt
      421 yrwlkngvpl spqsrvemvn gvlmihnvnq sdagmyqcla enkygaiyas aelkilasap
      481 tfalnqlkkt iivtkdqevv ieckpqgspk ptiswkkgdr avrenkriav lpdgslriln
      541 asksdegkyv crgenvfgsa eiiaslsvke ptrieltpkr teltvgesiv lnckaihdas
      601 ldvtfywtlk gqpidfeeeg ghfesiravl fhwipvttll vsqviyk
//
LOCUS       XP_054225125             635 aa            linear   PRI 05-AUG-2025
DEFINITION  contactin-5 isoform X4 [Homo sapiens].
ACCESSION   XP_054225125
VERSION     XP_054225125.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369150.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..635
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..635
                     /product="contactin-5 isoform X4"
                     /calculated_mol_wt=70242
     Region          98..193
                     /region_name="IgI_1_Contactin-5"
                     /note="First immunoglobulin (Ig) domain of contactin-5;
                     member of the I-set of Ig superfamily domains; cd05848"
                     /db_xref="CDD:409435"
     Site            order(98..99,180..183)
                     /site_type="other"
                     /note="interdomain interface [polypeptide binding]"
                     /db_xref="CDD:409435"
     Region          100..104
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409435"
     Region          107..112
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409435"
     Region          118..126
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409435"
     Region          131..137
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409435"
     Region          139..142
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409435"
     Region          149..153
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409435"
     Region          155..161
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409435"
     Region          168..177
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409435"
     Region          180..193
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409435"
     Region          202..287
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          213..217
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409392"
     Region          227..231
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409392"
     Region          252..256
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409392"
     Region          266..271
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409392"
     Region          282..285
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409392"
     Region          300..387
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          318..322
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409357"
     Region          331..335
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409357"
     Region          352..356
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409357"
     Region          366..371
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409357"
     Region          379..382
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409357"
     Region          392..475
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          407..411
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          420..424
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          441..445
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          455..460
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          468..471
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          480..568
                     /region_name="Ig5_Contactin"
                     /note="Fifth immunoglobulin (Ig) domain of contactin;
                     cd04969"
                     /db_xref="CDD:409358"
     Region          480..485
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409358"
     Region          488..493
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409358"
     Region          497..504
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409358"
     Region          512..516
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409358"
     Region          530..533
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409358"
     Region          534..539
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409358"
     Region          547..555
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409358"
     Region          561..568
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409358"
     Region          570..>624
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          589..593
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409359"
     Region          604..608
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409359"
     CDS             1..635
                     /gene="CNTN5"
                     /gene_synonym="HNB-2s; NB-2"
                     /coded_by="XM_054369150.1:532..2439"
                     /db_xref="GeneID:53942"
                     /db_xref="HGNC:HGNC:2175"
                     /db_xref="MIM:607219"
ORIGIN      
        1 masswklmlf lsvtmclsey skslpglsts yaallrikks sssslfgskt rprysspslg
       61 tlsasspswl gaaqnyyspi nlyhssdafk qdesvdygpv fvqepddiif ptdsdekkva
      121 lncevrgnpv psyrwlrngt eidlesdyry slidgtfiis npseakdsgh yqclatntvg
      181 silsreatlq faylgnfsgr trsavsvreg qgvvlmcspp phspeiiysw vfnefpsfva
      241 edsrrfisqe tgnlyiskvq tsdvgsyicl vkntvtnarv lspptpltlr ndgvmgeyep
      301 kievhfpftv taakgttvkm ecfalgnpvp titwmkvngy ipskarlrks qavleipnvq
      361 lddagiyecr aensrgknsf rgqlqvytyp hwveklndtq ldsgsplrwe ckatgkprpt
      421 yrwlkngvpl spqsrvemvn gvlmihnvnq sdagmyqcla enkygaiyas aelkilasap
      481 tfalnqlkkt iivtkdqevv ieckpqgspk ptiswkkgdr avrenkriav lpdgslriln
      541 asksdegkyv crgenvfgsa eiiaslsvke ptrieltpkr teltvgesiv lnckaihdas
      601 ldvtfywtlk gqpidfeeeg ghfesiradp qahlg
//
LOCUS       XP_054225126             573 aa            linear   PRI 05-AUG-2025
DEFINITION  contactin-5 isoform X5 [Homo sapiens].
ACCESSION   XP_054225126
VERSION     XP_054225126.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369151.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..573
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..573
                     /product="contactin-5 isoform X5"
                     /calculated_mol_wt=63782
     Region          24..119
                     /region_name="IgI_1_Contactin-5"
                     /note="First immunoglobulin (Ig) domain of contactin-5;
                     member of the I-set of Ig superfamily domains; cd05848"
                     /db_xref="CDD:409435"
     Site            order(24..25,106..109)
                     /site_type="other"
                     /note="interdomain interface [polypeptide binding]"
                     /db_xref="CDD:409435"
     Region          26..30
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409435"
     Region          33..38
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409435"
     Region          44..52
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409435"
     Region          57..63
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409435"
     Region          65..68
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409435"
     Region          75..79
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409435"
     Region          81..87
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409435"
     Region          94..103
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409435"
     Region          106..119
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409435"
     Region          128..213
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          139..143
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409392"
     Region          153..157
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409392"
     Region          178..182
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409392"
     Region          192..197
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409392"
     Region          208..211
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409392"
     Region          226..313
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          244..248
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409357"
     Region          257..261
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409357"
     Region          278..282
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409357"
     Region          292..297
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409357"
     Region          305..308
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409357"
     Region          318..401
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          333..337
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          346..350
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          367..371
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          381..386
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          394..397
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          406..494
                     /region_name="Ig5_Contactin"
                     /note="Fifth immunoglobulin (Ig) domain of contactin;
                     cd04969"
                     /db_xref="CDD:409358"
     Region          406..411
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409358"
     Region          414..419
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409358"
     Region          423..430
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409358"
     Region          438..442
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409358"
     Region          456..459
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409358"
     Region          460..465
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409358"
     Region          473..481
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409358"
     Region          487..494
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409358"
     Region          496..>550
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          515..519
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409359"
     Region          530..534
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409359"
     CDS             1..573
                     /gene="CNTN5"
                     /gene_synonym="HNB-2s; NB-2"
                     /coded_by="XM_054369151.1:532..2253"
                     /db_xref="GeneID:53942"
                     /db_xref="HGNC:HGNC:2175"
                     /db_xref="MIM:607219"
ORIGIN      
        1 masswklmlf lsvtmclses vdygpvfvqe pddiifptds dekkvalnce vrgnpvpsyr
       61 wlrngteidl esdyryslid gtfiisnpse akdsghyqcl atntvgsils reatlqfayl
      121 gnfsgrtrsa vsvregqgvv lmcsppphsp eiiyswvfne fpsfvaedsr rfisqetgnl
      181 yiskvqtsdv gsyiclvknt vtnarvlspp tpltlrndgv mgeyepkiev hfpftvtaak
      241 gttvkmecfa lgnpvptitw mkvngyipsk arlrksqavl eipnvqldda giyecraens
      301 rgknsfrgql qvytyphwve klndtqldsg splrweckat gkprptyrwl kngvplspqs
      361 rvemvngvlm ihnvnqsdag myqclaenky gaiyasaelk ilasaptfal nqlkktiivt
      421 kdqevvieck pqgspkptis wkkgdravre nkriavlpdg slrilnasks degkyvcrge
      481 nvfgsaeiia slsvkeptri eltpkrtelt vgesivlnck aihdasldvt fywtlkgqpi
      541 dfeeegghfe siravlfhwi pvttllvsqv iyk
//
LOCUS       XP_054225127             332 aa            linear   PRI 05-AUG-2025
DEFINITION  sialate O-acetylesterase isoform X1 [Homo sapiens].
ACCESSION   XP_054225127
VERSION     XP_054225127.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369152.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..332
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..332
                     /product="sialate O-acetylesterase isoform X1"
                     /calculated_mol_wt=37128
     Region          <18..>90
                     /region_name="SASA"
                     /note="Carbohydrate esterase, sialic acid-specific
                     acetylesterase; pfam03629"
                     /db_xref="CDD:427409"
     CDS             1..332
                     /gene="SIAE"
                     /gene_synonym="AIS6; CSE-C; CSEC; LSE; YSG2"
                     /coded_by="XM_054369152.1:2704..3702"
                     /db_xref="GeneID:54414"
                     /db_xref="HGNC:HGNC:18187"
                     /db_xref="MIM:610079"
ORIGIN      
        1 msavcwlfgr hlydtlqypi gliasswggt pieawssgrs lkacgvpkqg sipydsvtgp
       61 skhsvlwnam ihplcnmtlk gvvwyqgesn inyntdlync tfpaliedwr etfhrgsqgq
      121 terffpfglv qlssdlskks sddgfpqirw hqtadfgyvp npkmpntfma vamdlcdrds
      181 pfgsihprdk qtvayrlhlg aralaygekn ltfegplpek iellahkgll nltyyqqiqv
      241 qkkdnkifei sccsdhrckw lpasmntvst qsltlaidsc hgtvvalrya wttwpceykq
      301 cplyhpssal pappfiafit dqgpghqsnv ak
//
LOCUS       XP_054225128             274 aa            linear   PRI 05-AUG-2025
DEFINITION  sialate O-acetylesterase isoform X2 [Homo sapiens].
ACCESSION   XP_054225128
VERSION     XP_054225128.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369153.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..274
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..274
                     /product="sialate O-acetylesterase isoform X2"
                     /calculated_mol_wt=29594
     CDS             1..274
                     /gene="SIAE"
                     /gene_synonym="AIS6; CSE-C; CSEC; LSE; YSG2"
                     /coded_by="XM_054369153.1:32..856"
                     /db_xref="GeneID:54414"
                     /db_xref="HGNC:HGNC:18187"
                     /db_xref="MIM:610079"
ORIGIN      
        1 mvapglvlgl vlplilwadr sagigfrfas yinndmvlqk epagaviwgf gtpgatvtvt
       61 lrqgqetimk kvtsvkahsd twmvvldpvk pggpfevmaq qtlekinftl rvhdvlfgdv
      121 wlcsgqsnmq mtvlqifnat relsntaayq svrilsvspi qaeqeledlv avdlqwskpt
      181 sgffprlptn lpsccgemsl pstssvkisr pfgmgsasis rrclhskssl lsslvsvsvd
      241 nwslfransd lgspfsraff nplgtvvfps vhsa
//
LOCUS       XP_054225129             503 aa            linear   PRI 05-AUG-2025
DEFINITION  toll-interacting protein isoform X5 [Homo sapiens].
ACCESSION   XP_054225129
VERSION     XP_054225129.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369154.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..503
                     /product="toll-interacting protein isoform X5"
                     /calculated_mol_wt=54597
     Region          281..401
                     /region_name="C2_Tollip"
                     /note="C2 domain present in Toll-interacting protein
                     (Tollip); cd04016"
                     /db_xref="CDD:175983"
     Site            order(303,350,352,358)
                     /site_type="other"
                     /note="putative Ca2+ binding pocket [ion binding]"
                     /db_xref="CDD:175983"
     Region          459..499
                     /region_name="CUE_TOLIP"
                     /note="CUE domain found in the C-terminal of
                     toll-interacting protein (Tollip) and similar proteins;
                     cd14363"
                     /db_xref="CDD:270546"
     CDS             1..503
                     /gene="TOLLIP"
                     /gene_synonym="IL-1RAcPIP"
                     /coded_by="XM_054369154.1:1469..2980"
                     /db_xref="GeneID:54472"
                     /db_xref="HGNC:HGNC:16476"
                     /db_xref="MIM:606277"
ORIGIN      
        1 maqagtgfwc awqrrsggls tctlpkltsd tprvpgstry flkttaqgtg adrgpcrrlg
       61 lhptppatrp pphstsnqas tplhqqpglh ptppatrppp hstsnqastp lhqqpglhpt
      121 ppstrppphs tsnqastplh qqpglhptpp atrppphsts nqastplhqq pglhptppat
      181 rpppatrppp hstsnqastp llqqpglhpt ppaarpmlra ssatfhlwsm vyprplrplq
      241 vyigelpqdf lritptqqqr qvqldaqaaq qlqyggavgt vgrlnitvvq aklaknygmt
      301 rmdpycrlrl gyavyetpta hngaknprwn kvihctvppg vdsfyleifd erafsmddri
      361 awthitipes lrqgkvedkw yslsgrqgdd kegminlvms yallpaamvm ppqpvvlmpt
      421 vyqqgvgyvp itgmpavcsp gmvpvalppa avnaqprcse edlkaiqdmf pnmdqevirs
      481 vleaqrgnkd aainsllqmg eep
//
LOCUS       XP_054225130             229 aa            linear   PRI 05-AUG-2025
DEFINITION  toll-interacting protein isoform X1 [Homo sapiens].
ACCESSION   XP_054225130
VERSION     XP_054225130.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369155.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..229
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..229
                     /product="toll-interacting protein isoform X1"
                     /calculated_mol_wt=25857
     Region          52..172
                     /region_name="C2_Tollip"
                     /note="C2 domain present in Toll-interacting protein
                     (Tollip); cd04016"
                     /db_xref="CDD:175983"
     Site            order(74,121,123,129)
                     /site_type="other"
                     /note="putative Ca2+ binding pocket [ion binding]"
                     /db_xref="CDD:175983"
     CDS             1..229
                     /gene="TOLLIP"
                     /gene_synonym="IL-1RAcPIP"
                     /coded_by="XM_054369155.1:16..705"
                     /db_xref="GeneID:54472"
                     /db_xref="HGNC:HGNC:16476"
                     /db_xref="MIM:606277"
ORIGIN      
        1 mvyprplrpl qvyigelpqd flritptqqq rqvqldaqaa qqlqyggavg tvgrlnitvv
       61 qaklaknygm trmdpycrlr lgyavyetpt ahngaknprw nkvihctvpp gvdsfyleif
      121 derafsmddr iawthitipe slrqgkvedk wyslsgrqgd dkegminlvm syallpaamv
      181 mppqpvvlmp tvyqqgvgyv pitdivnfgt aphfiekfpr rcrnicqsl
//
LOCUS       XP_054225131             229 aa            linear   PRI 05-AUG-2025
DEFINITION  toll-interacting protein isoform X2 [Homo sapiens].
ACCESSION   XP_054225131
VERSION     XP_054225131.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369156.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..229
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..229
                     /product="toll-interacting protein isoform X2"
                     /calculated_mol_wt=25636
     Region          52..172
                     /region_name="C2_Tollip"
                     /note="C2 domain present in Toll-interacting protein
                     (Tollip); cd04016"
                     /db_xref="CDD:175983"
     Site            order(74,121,123,129)
                     /site_type="other"
                     /note="putative Ca2+ binding pocket [ion binding]"
                     /db_xref="CDD:175983"
     CDS             1..229
                     /gene="TOLLIP"
                     /gene_synonym="IL-1RAcPIP"
                     /coded_by="XM_054369156.1:135..824"
                     /db_xref="GeneID:54472"
                     /db_xref="HGNC:HGNC:16476"
                     /db_xref="MIM:606277"
ORIGIN      
        1 mattvstqrg pvyigelpqd flritptqqq rqvqldaqaa qqlqyggavg tvgrlnitvv
       61 qaklaknygm trmdpycrlr lgyavyetpt ahngaknprw nkvihctvpp gvdsfyleif
      121 derafsmddr iawthitipe slrqgkvedk wyslsgrqgd dkegminlvm syallpaamv
      181 mppqpvvlmp tvyqqgvgyv pitdivnfgt aphfiekfpr rcrnicqsl
//
LOCUS       XP_054225132             148 aa            linear   PRI 05-AUG-2025
DEFINITION  toll-interacting protein isoform X3 [Homo sapiens].
ACCESSION   XP_054225132
VERSION     XP_054225132.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369157.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..148
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..148
                     /product="toll-interacting protein isoform X3"
                     /calculated_mol_wt=16064
     Region          <1..46
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     Region          104..144
                     /region_name="CUE_TOLIP"
                     /note="CUE domain found in the C-terminal of
                     toll-interacting protein (Tollip) and similar proteins;
                     cd14363"
                     /db_xref="CDD:270546"
     CDS             1..148
                     /gene="TOLLIP"
                     /gene_synonym="IL-1RAcPIP"
                     /coded_by="XM_054369157.1:437..883"
                     /db_xref="GeneID:54472"
                     /db_xref="HGNC:HGNC:16476"
                     /db_xref="MIM:606277"
ORIGIN      
        1 mddriawthi tipeslrqgk vedkwyslsg rqgddkegmi nlvmsyallp aamvmppqpv
       61 vlmptvyqqg vgyvpitgmp avcspgmvpv alppaavnaq prcseedlka iqdmfpnmdq
      121 evirsvleaq rgnkdaains llqmgeep
//
LOCUS       XP_054225133             642 aa            linear   PRI 05-AUG-2025
DEFINITION  palmitoyltransferase ZDHHC13 isoform X1 [Homo sapiens].
ACCESSION   XP_054225133
VERSION     XP_054225133.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369158.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..642
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..642
                     /product="palmitoyltransferase ZDHHC13 isoform X1"
                     /calculated_mol_wt=73139
     Region          49..290
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Site            order(78..80,82..83,87,90,99,101,103,107..108,111..113,
                     115..116,120,123,132,134,136,141..142,145..147,149..150,
                     154,157,166)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          101..132
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          134..166
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          168..199
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          201..267
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          443..579
                     /region_name="DHHC"
                     /note="DHHC palmitoyltransferase; pfam01529"
                     /db_xref="CDD:396215"
     CDS             1..642
                     /gene="ZDHHC13"
                     /gene_synonym="HIP14L; HIP3RP"
                     /coded_by="XM_054369158.1:7..1935"
                     /db_xref="GeneID:54503"
                     /db_xref="HGNC:HGNC:18413"
                     /db_xref="MIM:612815"
ORIGIN      
        1 mqwcdlsllq ppppgfksfs gytsktpknc rnhshgphpp gfgrygicah enkelanare
       61 alpliedssn cdivkatqyg iferckelve agydvrqpdk envsllhwaa innrldlvrf
      121 yiskgavvdq lggdlnstpl hwairqghlp mvilllqhga dptlidgegf ssihlavlfq
      181 hmpiiaylis kgqsvnmtdv ngqtplmlsa hkvigpeptg fllkfnpsln vvdkihqntp
      241 lhwavaagnv navdklleag ssldiqnvkg etpldmalqn knqliihmlk teakmranqk
      301 frlwrwlqkc elflllmlsv itmwaigyil dfnsdswllk gcllvtlffl tslfprflvg
      361 yknlvylpta fllssvfwif mtwfilffpd lagapfyfsf ifsivaflyf fyktwatdpg
      421 ftkaseeekk vniitlaetg sldfrtfcts clirkplrsl hchvcnccva rydqhclwtg
      481 rcigfgnhhy yifflfflsm vcgwiiygsf iylsshcatt fkedglwtyl nqivacspwv
      541 lyilmlatfh fswstfllln qlfqiaflgl tsherislqk qskhmkqtls lrktpynlgf
      601 mqnladffqc gcfglvkpcv vdwtsqytmv fhparekvlr sv
//
LOCUS       XP_054225134             614 aa            linear   PRI 05-AUG-2025
DEFINITION  palmitoyltransferase ZDHHC13 isoform X2 [Homo sapiens].
ACCESSION   XP_054225134
VERSION     XP_054225134.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369159.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..614
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..614
                     /product="palmitoyltransferase ZDHHC13 isoform X2"
                     /calculated_mol_wt=69986
     Region          21..262
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Site            order(50..52,54..55,59,62,71,73,75,79..80,83..85,87..88,
                     92,95,104,106,108,113..114,117..119,121..122,126,129,138)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          73..104
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          106..138
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          140..171
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          173..239
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          415..551
                     /region_name="DHHC"
                     /note="DHHC palmitoyltransferase; pfam01529"
                     /db_xref="CDD:396215"
     CDS             1..614
                     /gene="ZDHHC13"
                     /gene_synonym="HIP14L; HIP3RP"
                     /coded_by="XM_054369159.1:265..2109"
                     /db_xref="GeneID:54503"
                     /db_xref="HGNC:HGNC:18413"
                     /db_xref="MIM:612815"
ORIGIN      
        1 mgrnhshgph ppgfgrygic ahenkelana realplieds sncdivkatq ygiferckel
       61 veagydvrqp dkenvsllhw aainnrldlv rfyiskgavv dqlggdlnst plhwairqgh
      121 lpmvilllqh gadptlidge gfssihlavl fqhmpiiayl iskgqsvnmt dvngqtplml
      181 sahkvigpep tgfllkfnps lnvvdkihqn tplhwavaag nvnavdklle agssldiqnv
      241 kgetpldmal qnknqliihm lkteakmran qkfrlwrwlq kcelflllml svitmwaigy
      301 ildfnsdswl lkgcllvtlf fltslfprfl vgyknlvylp tafllssvfw ifmtwfilff
      361 pdlagapfyf sfifsivafl yffyktwatd pgftkaseee kkvniitlae tgsldfrtfc
      421 tsclirkplr slhchvcncc varydqhclw tgrcigfgnh hyyifflffl smvcgwiiyg
      481 sfiylsshca ttfkedglwt ylnqivacsp wvlyilmlat fhfswstfll lnqlfqiafl
      541 gltsherisl qkqskhmkqt lslrktpynl gfmqnladff qcgcfglvkp cvvdwtsqyt
      601 mvfhparekv lrsv
//
LOCUS       XP_054225135             614 aa            linear   PRI 05-AUG-2025
DEFINITION  palmitoyltransferase ZDHHC13 isoform X3 [Homo sapiens].
ACCESSION   XP_054225135
VERSION     XP_054225135.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369160.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..614
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..614
                     /product="palmitoyltransferase ZDHHC13 isoform X3"
                     /calculated_mol_wt=69729
     Region          49..290
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Site            order(78..80,82..83,87,90,99,101,103,107..108,111..113,
                     115..116,120,123,132,134,136,141..142,145..147,149..150,
                     154,157,166)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          101..132
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          134..166
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          168..199
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          201..267
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          361..>488
                     /region_name="DHHC"
                     /note="DHHC palmitoyltransferase; cl19890"
                     /db_xref="CDD:418707"
     Region          443..551
                     /region_name="DHHC"
                     /note="DHHC palmitoyltransferase; pfam01529"
                     /db_xref="CDD:396215"
     CDS             1..614
                     /gene="ZDHHC13"
                     /gene_synonym="HIP14L; HIP3RP"
                     /coded_by="XM_054369160.1:10..1854"
                     /db_xref="GeneID:54503"
                     /db_xref="HGNC:HGNC:18413"
                     /db_xref="MIM:612815"
ORIGIN      
        1 mqwcdlsllq ppppgfksfs gytsktpknc rnhshgphpp gfgrygicah enkelanare
       61 alpliedssn cdivkatqyg iferckelve agydvrqpdk envsllhwaa innrldlvrf
      121 yiskgavvdq lggdlnstpl hwairqghlp mvilllqhga dptlidgegf ssihlavlfq
      181 hmpiiaylis kgqsvnmtdv ngqtplmlsa hkvigpeptg fllkfnpsln vvdkihqntp
      241 lhwavaagnv navdklleag ssldiqnvkg etpldmalqn knqliihmlk teakmranqk
      301 frlwrwlqkc elflllmlsv itmwaigyil dfnsdswllk gcllvtlffl tslfprflvg
      361 yknlvylpta fllssvfwif mtwfilffpd lagapfyfsf ifsivaflyf fyktwatdpg
      421 ftkaseeekk vniitlaetg sldfrtfcts clirkplrsl hchvcnccva rydqhclwtg
      481 rcidlsshca ttfkedglwt ylnqivacsp wvlyilmlat fhfswstfll lnqlfqiafl
      541 gltsherisl qkqskhmkqt lslrktpynl gfmqnladff qcgcfglvkp cvvdwtsqyt
      601 mvfhparekv lrsv
//
LOCUS       XP_054225136             594 aa            linear   PRI 05-AUG-2025
DEFINITION  palmitoyltransferase ZDHHC13 isoform X4 [Homo sapiens].
ACCESSION   XP_054225136
VERSION     XP_054225136.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369161.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..594
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..594
                     /product="palmitoyltransferase ZDHHC13 isoform X4"
                     /calculated_mol_wt=67348
     Region          29..270
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Site            order(58..60,62..63,67,70,79,81,83,87..88,91..93,95..96,
                     100,103,112,114,116,121..122,125..127,129..130,134,137,
                     146)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          81..112
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          114..146
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          148..179
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          181..247
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          341..>468
                     /region_name="DHHC"
                     /note="DHHC palmitoyltransferase; cl19890"
                     /db_xref="CDD:418707"
     Region          423..531
                     /region_name="DHHC"
                     /note="DHHC palmitoyltransferase; pfam01529"
                     /db_xref="CDD:396215"
     CDS             1..594
                     /gene="ZDHHC13"
                     /gene_synonym="HIP14L; HIP3RP"
                     /coded_by="XM_054369161.1:83..1867"
                     /db_xref="GeneID:54503"
                     /db_xref="HGNC:HGNC:18413"
                     /db_xref="MIM:612815"
ORIGIN      
        1 megpglgsqc rnhshgphpp gfgrygicah enkelanare alpliedssn cdivkatqyg
       61 iferckelve agydvrqpdk envsllhwaa innrldlvrf yiskgavvdq lggdlnstpl
      121 hwairqghlp mvilllqhga dptlidgegf ssihlavlfq hmpiiaylis kgqsvnmtdv
      181 ngqtplmlsa hkvigpeptg fllkfnpsln vvdkihqntp lhwavaagnv navdklleag
      241 ssldiqnvkg etpldmalqn knqliihmlk teakmranqk frlwrwlqkc elflllmlsv
      301 itmwaigyil dfnsdswllk gcllvtlffl tslfprflvg yknlvylpta fllssvfwif
      361 mtwfilffpd lagapfyfsf ifsivaflyf fyktwatdpg ftkaseeekk vniitlaetg
      421 sldfrtfcts clirkplrsl hchvcnccva rydqhclwtg rcidlsshca ttfkedglwt
      481 ylnqivacsp wvlyilmlat fhfswstfll lnqlfqiafl gltsherisl qkqskhmkqt
      541 lslrktpynl gfmqnladff qcgcfglvkp cvvdwtsqyt mvfhparekv lrsv
//
LOCUS       XP_054225137             558 aa            linear   PRI 05-AUG-2025
DEFINITION  palmitoyltransferase ZDHHC13 isoform X5 [Homo sapiens].
ACCESSION   XP_054225137
VERSION     XP_054225137.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369162.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..558
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..558
                     /product="palmitoyltransferase ZDHHC13 isoform X5"
                     /calculated_mol_wt=63488
     Region          49..290
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Site            order(78..80,82..83,87,90,99,101,103,107..108,111..113,
                     115..116,120,123,132,134,136,141..142,145..147,149..150,
                     154,157,166)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          101..132
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          134..166
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          168..199
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          201..267
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          443..>513
                     /region_name="DHHC"
                     /note="DHHC palmitoyltransferase; pfam01529"
                     /db_xref="CDD:396215"
     CDS             1..558
                     /gene="ZDHHC13"
                     /gene_synonym="HIP14L; HIP3RP"
                     /coded_by="XM_054369162.1:26..1702"
                     /db_xref="GeneID:54503"
                     /db_xref="HGNC:HGNC:18413"
                     /db_xref="MIM:612815"
ORIGIN      
        1 mqwcdlsllq ppppgfksfs gytsktpknc rnhshgphpp gfgrygicah enkelanare
       61 alpliedssn cdivkatqyg iferckelve agydvrqpdk envsllhwaa innrldlvrf
      121 yiskgavvdq lggdlnstpl hwairqghlp mvilllqhga dptlidgegf ssihlavlfq
      181 hmpiiaylis kgqsvnmtdv ngqtplmlsa hkvigpeptg fllkfnpsln vvdkihqntp
      241 lhwavaagnv navdklleag ssldiqnvkg etpldmalqn knqliihmlk teakmranqk
      301 frlwrwlqkc elflllmlsv itmwaigyil dfnsdswllk gcllvtlffl tslfprflvg
      361 yknlvylpta fllssvfwif mtwfilffpd lagapfyfsf ifsivaflyf fyktwatdpg
      421 ftkaseeekk vniitlaetg sldfrtfcts clirkplrsl hchvcnccva rydqhclwtg
      481 rcigfgnhhy yifflfflsm vcgwiiygsf iclftrwivs dsksvsilqv terkivdyhq
      541 eelcncqshl kmktfdle
//
LOCUS       XP_054225138             492 aa            linear   PRI 05-AUG-2025
DEFINITION  palmitoyltransferase ZDHHC13 isoform X6 [Homo sapiens].
ACCESSION   XP_054225138
VERSION     XP_054225138.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369163.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..492
                     /product="palmitoyltransferase ZDHHC13 isoform X6"
                     /calculated_mol_wt=56378
     Region          <1..140
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Site            order(18,20,24..25,28..30,32..33,37,40,49,51,53,57..58,
                     61..63,66..67,71,74,83,86,88,92..93,96..98,100..101,105,
                     108,117)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          18..49
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          51..83
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          86..117
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          293..429
                     /region_name="DHHC"
                     /note="DHHC palmitoyltransferase; pfam01529"
                     /db_xref="CDD:396215"
     CDS             1..492
                     /gene="ZDHHC13"
                     /gene_synonym="HIP14L; HIP3RP"
                     /coded_by="XM_054369163.1:401..1879"
                     /db_xref="GeneID:54503"
                     /db_xref="HGNC:HGNC:18413"
                     /db_xref="MIM:612815"
ORIGIN      
        1 mvilllqhga dptlidgegf ssihlavlfq hmpiiaylis kgqsvnmtdv ngqtplmlsa
       61 hkvigpeptg fllkfnpsln vvdkihqntp lhwavaagnv navdklleag ssldiqnvkg
      121 etpldmalqn knqliihmlk teakmranqk frlwrwlqkc elflllmlsv itmwaigyil
      181 dfnsdswllk gcllvtlffl tslfprflvg yknlvylpta fllssvfwif mtwfilffpd
      241 lagapfyfsf ifsivaflyf fyktwatdpg ftkaseeekk vniitlaetg sldfrtfcts
      301 clirkplrsl hchvcnccva rydqhclwtg rcigfgnhhy yifflfflsm vcgwiiygsf
      361 iylsshcatt fkedglwtyl nqivacspwv lyilmlatfh fswstfllln qlfqiaflgl
      421 tsherislqk qskhmkqtls lrktpynlgf mqnladffqc gcfglvkpcv vdwtsqytmv
      481 fhparekvlr sv
//
LOCUS       XP_054225139             492 aa            linear   PRI 05-AUG-2025
DEFINITION  palmitoyltransferase ZDHHC13 isoform X6 [Homo sapiens].
ACCESSION   XP_054225139
VERSION     XP_054225139.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369164.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..492
                     /product="palmitoyltransferase ZDHHC13 isoform X6"
                     /calculated_mol_wt=56378
     Region          <1..140
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Site            order(18,20,24..25,28..30,32..33,37,40,49,51,53,57..58,
                     61..63,66..67,71,74,83,86,88,92..93,96..98,100..101,105,
                     108,117)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          18..49
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          51..83
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          86..117
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          293..429
                     /region_name="DHHC"
                     /note="DHHC palmitoyltransferase; pfam01529"
                     /db_xref="CDD:396215"
     CDS             1..492
                     /gene="ZDHHC13"
                     /gene_synonym="HIP14L; HIP3RP"
                     /coded_by="XM_054369164.1:468..1946"
                     /db_xref="GeneID:54503"
                     /db_xref="HGNC:HGNC:18413"
                     /db_xref="MIM:612815"
ORIGIN      
        1 mvilllqhga dptlidgegf ssihlavlfq hmpiiaylis kgqsvnmtdv ngqtplmlsa
       61 hkvigpeptg fllkfnpsln vvdkihqntp lhwavaagnv navdklleag ssldiqnvkg
      121 etpldmalqn knqliihmlk teakmranqk frlwrwlqkc elflllmlsv itmwaigyil
      181 dfnsdswllk gcllvtlffl tslfprflvg yknlvylpta fllssvfwif mtwfilffpd
      241 lagapfyfsf ifsivaflyf fyktwatdpg ftkaseeekk vniitlaetg sldfrtfcts
      301 clirkplrsl hchvcnccva rydqhclwtg rcigfgnhhy yifflfflsm vcgwiiygsf
      361 iylsshcatt fkedglwtyl nqivacspwv lyilmlatfh fswstfllln qlfqiaflgl
      421 tsherislqk qskhmkqtls lrktpynlgf mqnladffqc gcfglvkpcv vdwtsqytmv
      481 fhparekvlr sv
//
LOCUS       XP_054225140             464 aa            linear   PRI 05-AUG-2025
DEFINITION  palmitoyltransferase ZDHHC13 isoform X7 [Homo sapiens].
ACCESSION   XP_054225140
VERSION     XP_054225140.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369165.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..464
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..464
                     /product="palmitoyltransferase ZDHHC13 isoform X7"
                     /calculated_mol_wt=52968
     Region          <1..140
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Site            order(18,20,24..25,28..30,32..33,37,40,49,51,53,57..58,
                     61..63,66..67,71,74,83,86,88,92..93,96..98,100..101,105,
                     108,117)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          18..49
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          51..83
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          86..117
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          211..>338
                     /region_name="DHHC"
                     /note="DHHC palmitoyltransferase; cl19890"
                     /db_xref="CDD:418707"
     Region          293..401
                     /region_name="DHHC"
                     /note="DHHC palmitoyltransferase; pfam01529"
                     /db_xref="CDD:396215"
     CDS             1..464
                     /gene="ZDHHC13"
                     /gene_synonym="HIP14L; HIP3RP"
                     /coded_by="XM_054369165.1:468..1862"
                     /db_xref="GeneID:54503"
                     /db_xref="HGNC:HGNC:18413"
                     /db_xref="MIM:612815"
ORIGIN      
        1 mvilllqhga dptlidgegf ssihlavlfq hmpiiaylis kgqsvnmtdv ngqtplmlsa
       61 hkvigpeptg fllkfnpsln vvdkihqntp lhwavaagnv navdklleag ssldiqnvkg
      121 etpldmalqn knqliihmlk teakmranqk frlwrwlqkc elflllmlsv itmwaigyil
      181 dfnsdswllk gcllvtlffl tslfprflvg yknlvylpta fllssvfwif mtwfilffpd
      241 lagapfyfsf ifsivaflyf fyktwatdpg ftkaseeekk vniitlaetg sldfrtfcts
      301 clirkplrsl hchvcnccva rydqhclwtg rcidlsshca ttfkedglwt ylnqivacsp
      361 wvlyilmlat fhfswstfll lnqlfqiafl gltsherisl qkqskhmkqt lslrktpynl
      421 gfmqnladff qcgcfglvkp cvvdwtsqyt mvfhparekv lrsv
//
LOCUS       XP_054225141             464 aa            linear   PRI 05-AUG-2025
DEFINITION  palmitoyltransferase ZDHHC13 isoform X7 [Homo sapiens].
ACCESSION   XP_054225141
VERSION     XP_054225141.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369166.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..464
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..464
                     /product="palmitoyltransferase ZDHHC13 isoform X7"
                     /calculated_mol_wt=52968
     Region          <1..140
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Site            order(18,20,24..25,28..30,32..33,37,40,49,51,53,57..58,
                     61..63,66..67,71,74,83,86,88,92..93,96..98,100..101,105,
                     108,117)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          18..49
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          51..83
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          86..117
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          211..>338
                     /region_name="DHHC"
                     /note="DHHC palmitoyltransferase; cl19890"
                     /db_xref="CDD:418707"
     Region          293..401
                     /region_name="DHHC"
                     /note="DHHC palmitoyltransferase; pfam01529"
                     /db_xref="CDD:396215"
     CDS             1..464
                     /gene="ZDHHC13"
                     /gene_synonym="HIP14L; HIP3RP"
                     /coded_by="XM_054369166.1:327..1721"
                     /db_xref="GeneID:54503"
                     /db_xref="HGNC:HGNC:18413"
                     /db_xref="MIM:612815"
ORIGIN      
        1 mvilllqhga dptlidgegf ssihlavlfq hmpiiaylis kgqsvnmtdv ngqtplmlsa
       61 hkvigpeptg fllkfnpsln vvdkihqntp lhwavaagnv navdklleag ssldiqnvkg
      121 etpldmalqn knqliihmlk teakmranqk frlwrwlqkc elflllmlsv itmwaigyil
      181 dfnsdswllk gcllvtlffl tslfprflvg yknlvylpta fllssvfwif mtwfilffpd
      241 lagapfyfsf ifsivaflyf fyktwatdpg ftkaseeekk vniitlaetg sldfrtfcts
      301 clirkplrsl hchvcnccva rydqhclwtg rcidlsshca ttfkedglwt ylnqivacsp
      361 wvlyilmlat fhfswstfll lnqlfqiafl gltsherisl qkqskhmkqt lslrktpynl
      421 gfmqnladff qcgcfglvkp cvvdwtsqyt mvfhparekv lrsv
//
LOCUS       XP_054225142             377 aa            linear   PRI 05-AUG-2025
DEFINITION  palmitoyltransferase ZDHHC13 isoform X8 [Homo sapiens].
ACCESSION   XP_054225142
VERSION     XP_054225142.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369167.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..377
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..377
                     /product="palmitoyltransferase ZDHHC13 isoform X8"
                     /calculated_mol_wt=42145
     Region          49..290
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Site            order(78..80,82..83,87,90,99,101,103,107..108,111..113,
                     115..116,120,123,132,134,136,141..142,145..147,149..150,
                     154,157,166)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          101..132
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          134..166
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          168..199
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          201..267
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     CDS             1..377
                     /gene="ZDHHC13"
                     /gene_synonym="HIP14L; HIP3RP"
                     /coded_by="XM_054369167.1:25..1158"
                     /db_xref="GeneID:54503"
                     /db_xref="HGNC:HGNC:18413"
                     /db_xref="MIM:612815"
ORIGIN      
        1 mqwcdlsllq ppppgfksfs gytsktpknc rnhshgphpp gfgrygicah enkelanare
       61 alpliedssn cdivkatqyg iferckelve agydvrqpdk envsllhwaa innrldlvrf
      121 yiskgavvdq lggdlnstpl hwairqghlp mvilllqhga dptlidgegf ssihlavlfq
      181 hmpiiaylis kgqsvnmtdv ngqtplmlsa hkvigpeptg fllkfnpsln vvdkihqntp
      241 lhwavaagnv navdklleag ssldiqnvkg etpldmalqn knqliihmlk teakmranqk
      301 frlwrwlqkc elflllmlsv itmwaigyil dfnsdswllk gcllvtlffl tslfprissp
      361 lqklalwtse hfvhhvl
//
LOCUS       XP_054225144             565 aa            linear   PRI 05-AUG-2025
DEFINITION  roundabout homolog 4 isoform X2 [Homo sapiens].
ACCESSION   XP_054225144
VERSION     XP_054225144.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369169.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..565
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..565
                     /product="roundabout homolog 4 isoform X2"
                     /calculated_mol_wt=60247
     Region          <125..434
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..565
                     /gene="ROBO4"
                     /gene_synonym="AOVD3; ECSM4; MRB"
                     /coded_by="XM_054369169.1:43..1740"
                     /db_xref="GeneID:54538"
                     /db_xref="HGNC:HGNC:17985"
                     /db_xref="MIM:607528"
ORIGIN      
        1 meratqepse hgpwtleqlr atlkrpevia tcgvalwlll lgtavcihrr rrarvhlgpg
       61 lyrytsedai lkhrmdhsds qwladtwrst sgsrdlssss slssrlgada rdpldcrrsl
      121 lswdsrspgv pllpdtstfy gsliaelpss tparpspqvp avrrlppqla qlsspcsssd
      181 slcsrrglss prlslapaea wkakkkqelq hansspllrg shslelrace lgnrgsknls
      241 qspgavpqal vawralgpkl lsssnelvtr hlppaplfph etpptqsqqt qppvapqaps
      301 sillpaapip ilspcsppsp qasslsgpsp assrlssssl sslgedqdsv ltpeevalcl
      361 elsegeetpr nsvspmprap sppttygyis vptaseftdm grtgggvgpk ggvllcpprp
      421 cltptpsegs langwgsase dnaasarasl vsssdgsfla dahfaralav avdsfgfgle
      481 preadcvfid assppsprde ifltpnlslp lwewrpdwle dmevshtqrl grgmppwppd
      541 sqissqrsql hcrmpkagas pvdys
//
LOCUS       XP_054225145             327 aa            linear   PRI 05-AUG-2025
DEFINITION  solute carrier family 35 member F2 isoform X1 [Homo sapiens].
ACCESSION   XP_054225145
VERSION     XP_054225145.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369170.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..327
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..327
                     /product="solute carrier family 35 member F2 isoform X1"
                     /calculated_mol_wt=36174
     Region          1..287
                     /region_name="SLC35F"
                     /note="Solute carrier family 35; pfam06027"
                     /db_xref="CDD:283644"
     CDS             1..327
                     /gene="SLC35F2"
                     /gene_synonym="HSNOV1"
                     /coded_by="XM_054369170.1:92..1075"
                     /db_xref="GeneID:54733"
                     /db_xref="HGNC:HGNC:23615"
                     /db_xref="MIM:620350"
ORIGIN      
        1 mlslcicgta itsqylaery kvntpmlqsf inycllfliy tvmlafrsgs dnllvilkrk
       61 wwkyillgla dveanyvivr ayqyttltsv qlldcfgipv lmalswfilh aryrvihfia
      121 vavcllgvgt mvgadilagr ednsgsdvli gdilvllgas lyaisnvcee yivkklsrqe
      181 flgmvglfgt iisgiqlliv eykdiasihw dwkiallfva falcmfclys fmplvikvts
      241 atsvnlgilt adlyslfvgl flfgykfsgl yilsftvimv gfilycstpt rtaepaessv
      301 ppvtsigidn lglkleenlq ethsavl
//
LOCUS       XP_054225146             264 aa            linear   PRI 05-AUG-2025
DEFINITION  tripartite motif-containing protein 44 isoform X1 [Homo sapiens].
ACCESSION   XP_054225146
VERSION     XP_054225146.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369171.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..264
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..264
                     /product="tripartite motif-containing protein 44 isoform
                     X1"
                     /calculated_mol_wt=29189
     Region          15..60
                     /region_name="Bbox1_TRIM44"
                     /note="B-box-type 1 zinc finger found in tripartite
                     motif-containing protein 44 (TRIM44) and similar proteins;
                     cd19841"
                     /db_xref="CDD:380899"
     Region          177..215
                     /region_name="Bbox_SF"
                     /note="B-box-type zinc finger superfamily; cl00034"
                     /db_xref="CDD:469587"
     CDS             1..264
                     /gene="TRIM44"
                     /gene_synonym="AN3; DIPB; HSA249128; MC7"
                     /coded_by="XM_054369171.1:338..1132"
                     /db_xref="GeneID:54765"
                     /db_xref="HGNC:HGNC:19016"
                     /db_xref="MIM:612298"
ORIGIN      
        1 masgvgaafe elphdgtcde cepdeapgae evcrecgfcy crrhaeahrq kflshhlaey
       61 vhgsqawtpp adgegagkee aevkveqere ieseageese seeeseseee seteeesede
      121 sdeeseedse eemedeqese aeednqeege seaegeteae sefdpeieme aervakrkcp
      181 dhgldlstyc qedrqlicvl cpvigahqgh qlstldeafe elrskdsggl kaamielver
      241 lkfkssdpkg deegpsgase eedt
//
LOCUS       XP_054225147             293 aa            linear   PRI 05-AUG-2025
DEFINITION  protein BTG4 isoform X1 [Homo sapiens].
ACCESSION   XP_054225147
VERSION     XP_054225147.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369172.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..293
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..293
                     /product="protein BTG4 isoform X1"
                     /calculated_mol_wt=34108
     Region          1..116
                     /region_name="BTG"
                     /note="BTG family; pfam07742"
                     /db_xref="CDD:462251"
     CDS             1..293
                     /gene="BTG4"
                     /gene_synonym="APRO3; OOMD8; OZEMA8; PC3B"
                     /coded_by="XM_054369172.1:233..1114"
                     /db_xref="GeneID:54766"
                     /db_xref="HGNC:HGNC:13862"
                     /db_xref="MIM:605673"
ORIGIN      
        1 mrdeiattvf fvtrlvkkhd klskqqiedf aeklmtilfe tyrshwhsdc pskgqafrci
       61 rinnnqnkdp ileracvesn vdfshlglpk emtiwvdpfe vccrygeknh pftvasfkgr
      121 weewelyqqi syavsrassd vssgtscdee scskeprvip kvsnpksiyq venlkqpfqs
      181 wlqiprkknv vdgrvgllgn tyhgsqkhpk cyrpamhrld retiprkrtf ftqqllpysl
      241 rcvfvfsyvf lhqrcpkawn rtwhnymmle csgtitahld llgssnppts tfk
//
LOCUS       XP_054225148             293 aa            linear   PRI 05-AUG-2025
DEFINITION  protein BTG4 isoform X1 [Homo sapiens].
ACCESSION   XP_054225148
VERSION     XP_054225148.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369173.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 1% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..293
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..293
                     /product="protein BTG4 isoform X1"
                     /calculated_mol_wt=34108
     Region          1..116
                     /region_name="BTG"
                     /note="BTG family; pfam07742"
                     /db_xref="CDD:462251"
     CDS             1..293
                     /gene="BTG4"
                     /gene_synonym="APRO3; OOMD8; OZEMA8; PC3B"
                     /coded_by="XM_054369173.1:317..1198"
                     /db_xref="GeneID:54766"
                     /db_xref="HGNC:HGNC:13862"
                     /db_xref="MIM:605673"
ORIGIN      
        1 mrdeiattvf fvtrlvkkhd klskqqiedf aeklmtilfe tyrshwhsdc pskgqafrci
       61 rinnnqnkdp ileracvesn vdfshlglpk emtiwvdpfe vccrygeknh pftvasfkgr
      121 weewelyqqi syavsrassd vssgtscdee scskeprvip kvsnpksiyq venlkqpfqs
      181 wlqiprkknv vdgrvgllgn tyhgsqkhpk cyrpamhrld retiprkrtf ftqqllpysl
      241 rcvfvfsyvf lhqrcpkawn rtwhnymmle csgtitahld llgssnppts tfk
//
LOCUS       XP_054225149             293 aa            linear   PRI 05-AUG-2025
DEFINITION  protein BTG4 isoform X1 [Homo sapiens].
ACCESSION   XP_054225149
VERSION     XP_054225149.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369174.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..293
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..293
                     /product="protein BTG4 isoform X1"
                     /calculated_mol_wt=34108
     Region          1..116
                     /region_name="BTG"
                     /note="BTG family; pfam07742"
                     /db_xref="CDD:462251"
     CDS             1..293
                     /gene="BTG4"
                     /gene_synonym="APRO3; OOMD8; OZEMA8; PC3B"
                     /coded_by="XM_054369174.1:86..967"
                     /db_xref="GeneID:54766"
                     /db_xref="HGNC:HGNC:13862"
                     /db_xref="MIM:605673"
ORIGIN      
        1 mrdeiattvf fvtrlvkkhd klskqqiedf aeklmtilfe tyrshwhsdc pskgqafrci
       61 rinnnqnkdp ileracvesn vdfshlglpk emtiwvdpfe vccrygeknh pftvasfkgr
      121 weewelyqqi syavsrassd vssgtscdee scskeprvip kvsnpksiyq venlkqpfqs
      181 wlqiprkknv vdgrvgllgn tyhgsqkhpk cyrpamhrld retiprkrtf ftqqllpysl
      241 rcvfvfsyvf lhqrcpkawn rtwhnymmle csgtitahld llgssnppts tfk
//
LOCUS       XP_054225150             293 aa            linear   PRI 05-AUG-2025
DEFINITION  protein BTG4 isoform X1 [Homo sapiens].
ACCESSION   XP_054225150
VERSION     XP_054225150.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369175.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 1% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..293
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..293
                     /product="protein BTG4 isoform X1"
                     /calculated_mol_wt=34108
     Region          1..116
                     /region_name="BTG"
                     /note="BTG family; pfam07742"
                     /db_xref="CDD:462251"
     CDS             1..293
                     /gene="BTG4"
                     /gene_synonym="APRO3; OOMD8; OZEMA8; PC3B"
                     /coded_by="XM_054369175.1:330..1211"
                     /db_xref="GeneID:54766"
                     /db_xref="HGNC:HGNC:13862"
                     /db_xref="MIM:605673"
ORIGIN      
        1 mrdeiattvf fvtrlvkkhd klskqqiedf aeklmtilfe tyrshwhsdc pskgqafrci
       61 rinnnqnkdp ileracvesn vdfshlglpk emtiwvdpfe vccrygeknh pftvasfkgr
      121 weewelyqqi syavsrassd vssgtscdee scskeprvip kvsnpksiyq venlkqpfqs
      181 wlqiprkknv vdgrvgllgn tyhgsqkhpk cyrpamhrld retiprkrtf ftqqllpysl
      241 rcvfvfsyvf lhqrcpkawn rtwhnymmle csgtitahld llgssnppts tfk
//
LOCUS       XP_054225151             293 aa            linear   PRI 05-AUG-2025
DEFINITION  protein BTG4 isoform X1 [Homo sapiens].
ACCESSION   XP_054225151
VERSION     XP_054225151.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369176.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..293
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..293
                     /product="protein BTG4 isoform X1"
                     /calculated_mol_wt=34108
     Region          1..116
                     /region_name="BTG"
                     /note="BTG family; pfam07742"
                     /db_xref="CDD:462251"
     CDS             1..293
                     /gene="BTG4"
                     /gene_synonym="APRO3; OOMD8; OZEMA8; PC3B"
                     /coded_by="XM_054369176.1:430..1311"
                     /db_xref="GeneID:54766"
                     /db_xref="HGNC:HGNC:13862"
                     /db_xref="MIM:605673"
ORIGIN      
        1 mrdeiattvf fvtrlvkkhd klskqqiedf aeklmtilfe tyrshwhsdc pskgqafrci
       61 rinnnqnkdp ileracvesn vdfshlglpk emtiwvdpfe vccrygeknh pftvasfkgr
      121 weewelyqqi syavsrassd vssgtscdee scskeprvip kvsnpksiyq venlkqpfqs
      181 wlqiprkknv vdgrvgllgn tyhgsqkhpk cyrpamhrld retiprkrtf ftqqllpysl
      241 rcvfvfsyvf lhqrcpkawn rtwhnymmle csgtitahld llgssnppts tfk
//
LOCUS       XP_054225152             273 aa            linear   PRI 05-AUG-2025
DEFINITION  protein BTG4 isoform X2 [Homo sapiens].
ACCESSION   XP_054225152
VERSION     XP_054225152.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369177.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 1% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..273
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..273
                     /product="protein BTG4 isoform X2"
                     /calculated_mol_wt=32111
     Region          1..116
                     /region_name="BTG"
                     /note="BTG family; pfam07742"
                     /db_xref="CDD:462251"
     CDS             1..273
                     /gene="BTG4"
                     /gene_synonym="APRO3; OOMD8; OZEMA8; PC3B"
                     /coded_by="XM_054369177.1:233..1054"
                     /db_xref="GeneID:54766"
                     /db_xref="HGNC:HGNC:13862"
                     /db_xref="MIM:605673"
ORIGIN      
        1 mrdeiattvf fvtrlvkkhd klskqqiedf aeklmtilfe tyrshwhsdc pskgqafrci
       61 rinnnqnkdp ileracvesn vdfshlglpk emtiwvdpfe vccrygeknh pftvasfkgr
      121 weewelyqqi syavsrassd vssgtscdee scskeprvip kvsnpksiyq venlkqpfqs
      181 wlqiprkknv vdgrvgllgn tyhgsqkhpk cyrpamhrld retiprkrtf ftqqllpysl
      241 rcvfvfsyvf lhqrcpkawn rtwhnymmnl sfl
//
LOCUS       XP_054225153             259 aa            linear   PRI 05-AUG-2025
DEFINITION  protein BTG4 isoform X3 [Homo sapiens].
ACCESSION   XP_054225153
VERSION     XP_054225153.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369178.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 1% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..259
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..259
                     /product="protein BTG4 isoform X3"
                     /calculated_mol_wt=30060
     Region          <2..82
                     /region_name="BTG"
                     /note="BTG family; pfam07742"
                     /db_xref="CDD:462251"
     CDS             1..259
                     /gene="BTG4"
                     /gene_synonym="APRO3; OOMD8; OZEMA8; PC3B"
                     /coded_by="XM_054369178.1:304..1083"
                     /db_xref="GeneID:54766"
                     /db_xref="HGNC:HGNC:13862"
                     /db_xref="MIM:605673"
ORIGIN      
        1 mtilfetyrs hwhsdcpskg qafrcirinn nqnkdpiler acvesnvdfs hlglpkemti
       61 wvdpfevccr ygeknhpftv asfkgrweew elyqqisyav srassdvssg tscdeescsk
      121 eprvipkvsn pksiyqvenl kqpfqswlqi prkknvvdgr vgllgntyhg sqkhpkcyrp
      181 amhrldreti prkrtfftqq llpyslrcvf vfsyvflhqr cpkawnrtwh nymmlecsgt
      241 itahldllgs snpptstfk
//
LOCUS       XP_054225154             244 aa            linear   PRI 05-AUG-2025
DEFINITION  protein BTG4 isoform X4 [Homo sapiens].
ACCESSION   XP_054225154
VERSION     XP_054225154.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369179.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 1% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..244
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..244
                     /product="protein BTG4 isoform X4"
                     /calculated_mol_wt=27867
     Region          1..116
                     /region_name="BTG"
                     /note="BTG family; pfam07742"
                     /db_xref="CDD:462251"
     CDS             1..244
                     /gene="BTG4"
                     /gene_synonym="APRO3; OOMD8; OZEMA8; PC3B"
                     /coded_by="XM_054369179.1:233..967"
                     /db_xref="GeneID:54766"
                     /db_xref="HGNC:HGNC:13862"
                     /db_xref="MIM:605673"
ORIGIN      
        1 mrdeiattvf fvtrlvkkhd klskqqiedf aeklmtilfe tyrshwhsdc pskgqafrci
       61 rinnnqnkdp ileracvesn vdfshlglpk emtiwvdpfe vccrygeknh pftvasfkgr
      121 weewelyqqi syavsrassd vssgtscdee scskeprvip kvsnpksiyq venlkqpfqs
      181 wlqiprkknv vdgrvgllgn tyhgsqkhpk cyrpamhrld rndgslghia alfcgtnspt
      241 lngi
//
LOCUS       XP_054225155             226 aa            linear   PRI 05-AUG-2025
DEFINITION  protein BTG4 isoform X5 [Homo sapiens].
ACCESSION   XP_054225155
VERSION     XP_054225155.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369180.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 1% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..226
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..226
                     /product="protein BTG4 isoform X5"
                     /calculated_mol_wt=26171
     Region          1..116
                     /region_name="BTG"
                     /note="BTG family; pfam07742"
                     /db_xref="CDD:462251"
     CDS             1..226
                     /gene="BTG4"
                     /gene_synonym="APRO3; OOMD8; OZEMA8; PC3B"
                     /coded_by="XM_054369180.1:233..913"
                     /db_xref="GeneID:54766"
                     /db_xref="HGNC:HGNC:13862"
                     /db_xref="MIM:605673"
ORIGIN      
        1 mrdeiattvf fvtrlvkkhd klskqqiedf aeklmtilfe tyrshwhsdc pskgqafrci
       61 rinnnqnkdp ileracvesn vdfshlglpk emtiwvdpfe vccrygeknh pftvasfkgr
      121 weewelyqqi syavsrassd vssgtscdee scskeprvip kvsnpksiyq venlkqpfqs
      181 wlqiprkknv vdgrvgllgn tyhgsqkhpk cyrpamhrld rlnlaf
//
LOCUS       XP_054225156             544 aa            linear   PRI 05-AUG-2025
DEFINITION  NXPE family member 4 isoform X1 [Homo sapiens].
ACCESSION   XP_054225156
VERSION     XP_054225156.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369181.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..544
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..544
                     /product="NXPE family member 4 isoform X1"
                     /calculated_mol_wt=62132
     Region          <121..259
                     /region_name="Neurexophilin"
                     /note="pfam06312"
                     /db_xref="CDD:428882"
     CDS             1..544
                     /gene="NXPE4"
                     /gene_synonym="C11orf33; FAM55D"
                     /coded_by="XM_054369181.1:383..2017"
                     /db_xref="GeneID:54827"
                     /db_xref="HGNC:HGNC:23117"
                     /db_xref="MIM:618133"
ORIGIN      
        1 mkisminyks llallfilas wiiftvfqns tkvwsalnls islhywnnst kslfpktpli
       61 slkpltetel rikeiiekld qqipprpfth vntttsaths tatilnprdt ycrgdqlhil
      121 levrdhlgrr kqyggdflra rmsspalmag asgkvtdfnn gtylvsftlf wegqvslsll
      181 lihpsegvsa lwsarnqgyd rviftgqfvn gtsqvhsecg lilntnaelc qyldnrdqeg
      241 fycvrpqhmp caalthmysk nkkvsylskq ekslfersnv gveimekfnt isvskcnket
      301 vamkekckfg mtstipsghv wrntwnpvsc slatvkmkec lrgkliylmg dstirqwmey
      361 fkasintlks vdlhesgklq hqlavdldrn iniqwqkycy pligsmtysv kemeyltrai
      421 drtggekntv ivislgqhfr pfpidvfirr alnvhkaiqh lllrspdtmv iiktenirem
      481 yndaerfsdf hgyiqyliik difqdlsvsi idawditiay gtnnvhppqh vvgnqinill
      541 nyic
//
LOCUS       XP_054225157             544 aa            linear   PRI 05-AUG-2025
DEFINITION  NXPE family member 4 isoform X1 [Homo sapiens].
ACCESSION   XP_054225157
VERSION     XP_054225157.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369182.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..544
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..544
                     /product="NXPE family member 4 isoform X1"
                     /calculated_mol_wt=62132
     Region          <121..259
                     /region_name="Neurexophilin"
                     /note="pfam06312"
                     /db_xref="CDD:428882"
     CDS             1..544
                     /gene="NXPE4"
                     /gene_synonym="C11orf33; FAM55D"
                     /coded_by="XM_054369182.1:259..1893"
                     /db_xref="GeneID:54827"
                     /db_xref="HGNC:HGNC:23117"
                     /db_xref="MIM:618133"
ORIGIN      
        1 mkisminyks llallfilas wiiftvfqns tkvwsalnls islhywnnst kslfpktpli
       61 slkpltetel rikeiiekld qqipprpfth vntttsaths tatilnprdt ycrgdqlhil
      121 levrdhlgrr kqyggdflra rmsspalmag asgkvtdfnn gtylvsftlf wegqvslsll
      181 lihpsegvsa lwsarnqgyd rviftgqfvn gtsqvhsecg lilntnaelc qyldnrdqeg
      241 fycvrpqhmp caalthmysk nkkvsylskq ekslfersnv gveimekfnt isvskcnket
      301 vamkekckfg mtstipsghv wrntwnpvsc slatvkmkec lrgkliylmg dstirqwmey
      361 fkasintlks vdlhesgklq hqlavdldrn iniqwqkycy pligsmtysv kemeyltrai
      421 drtggekntv ivislgqhfr pfpidvfirr alnvhkaiqh lllrspdtmv iiktenirem
      481 yndaerfsdf hgyiqyliik difqdlsvsi idawditiay gtnnvhppqh vvgnqinill
      541 nyic
//
LOCUS       XP_054225158             544 aa            linear   PRI 05-AUG-2025
DEFINITION  NXPE family member 4 isoform X1 [Homo sapiens].
ACCESSION   XP_054225158
VERSION     XP_054225158.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369183.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..544
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..544
                     /product="NXPE family member 4 isoform X1"
                     /calculated_mol_wt=62132
     Region          <121..259
                     /region_name="Neurexophilin"
                     /note="pfam06312"
                     /db_xref="CDD:428882"
     CDS             1..544
                     /gene="NXPE4"
                     /gene_synonym="C11orf33; FAM55D"
                     /coded_by="XM_054369183.1:509..2143"
                     /db_xref="GeneID:54827"
                     /db_xref="HGNC:HGNC:23117"
                     /db_xref="MIM:618133"
ORIGIN      
        1 mkisminyks llallfilas wiiftvfqns tkvwsalnls islhywnnst kslfpktpli
       61 slkpltetel rikeiiekld qqipprpfth vntttsaths tatilnprdt ycrgdqlhil
      121 levrdhlgrr kqyggdflra rmsspalmag asgkvtdfnn gtylvsftlf wegqvslsll
      181 lihpsegvsa lwsarnqgyd rviftgqfvn gtsqvhsecg lilntnaelc qyldnrdqeg
      241 fycvrpqhmp caalthmysk nkkvsylskq ekslfersnv gveimekfnt isvskcnket
      301 vamkekckfg mtstipsghv wrntwnpvsc slatvkmkec lrgkliylmg dstirqwmey
      361 fkasintlks vdlhesgklq hqlavdldrn iniqwqkycy pligsmtysv kemeyltrai
      421 drtggekntv ivislgqhfr pfpidvfirr alnvhkaiqh lllrspdtmv iiktenirem
      481 yndaerfsdf hgyiqyliik difqdlsvsi idawditiay gtnnvhppqh vvgnqinill
      541 nyic
//
LOCUS       XP_054225159             544 aa            linear   PRI 05-AUG-2025
DEFINITION  NXPE family member 4 isoform X1 [Homo sapiens].
ACCESSION   XP_054225159
VERSION     XP_054225159.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369184.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..544
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..544
                     /product="NXPE family member 4 isoform X1"
                     /calculated_mol_wt=62132
     Region          <121..259
                     /region_name="Neurexophilin"
                     /note="pfam06312"
                     /db_xref="CDD:428882"
     CDS             1..544
                     /gene="NXPE4"
                     /gene_synonym="C11orf33; FAM55D"
                     /coded_by="XM_054369184.1:249..1883"
                     /db_xref="GeneID:54827"
                     /db_xref="HGNC:HGNC:23117"
                     /db_xref="MIM:618133"
ORIGIN      
        1 mkisminyks llallfilas wiiftvfqns tkvwsalnls islhywnnst kslfpktpli
       61 slkpltetel rikeiiekld qqipprpfth vntttsaths tatilnprdt ycrgdqlhil
      121 levrdhlgrr kqyggdflra rmsspalmag asgkvtdfnn gtylvsftlf wegqvslsll
      181 lihpsegvsa lwsarnqgyd rviftgqfvn gtsqvhsecg lilntnaelc qyldnrdqeg
      241 fycvrpqhmp caalthmysk nkkvsylskq ekslfersnv gveimekfnt isvskcnket
      301 vamkekckfg mtstipsghv wrntwnpvsc slatvkmkec lrgkliylmg dstirqwmey
      361 fkasintlks vdlhesgklq hqlavdldrn iniqwqkycy pligsmtysv kemeyltrai
      421 drtggekntv ivislgqhfr pfpidvfirr alnvhkaiqh lllrspdtmv iiktenirem
      481 yndaerfsdf hgyiqyliik difqdlsvsi idawditiay gtnnvhppqh vvgnqinill
      541 nyic
//
LOCUS       XP_054225160             544 aa            linear   PRI 05-AUG-2025
DEFINITION  NXPE family member 4 isoform X1 [Homo sapiens].
ACCESSION   XP_054225160
VERSION     XP_054225160.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369185.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..544
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..544
                     /product="NXPE family member 4 isoform X1"
                     /calculated_mol_wt=62132
     Region          <121..259
                     /region_name="Neurexophilin"
                     /note="pfam06312"
                     /db_xref="CDD:428882"
     CDS             1..544
                     /gene="NXPE4"
                     /gene_synonym="C11orf33; FAM55D"
                     /coded_by="XM_054369185.1:411..2045"
                     /db_xref="GeneID:54827"
                     /db_xref="HGNC:HGNC:23117"
                     /db_xref="MIM:618133"
ORIGIN      
        1 mkisminyks llallfilas wiiftvfqns tkvwsalnls islhywnnst kslfpktpli
       61 slkpltetel rikeiiekld qqipprpfth vntttsaths tatilnprdt ycrgdqlhil
      121 levrdhlgrr kqyggdflra rmsspalmag asgkvtdfnn gtylvsftlf wegqvslsll
      181 lihpsegvsa lwsarnqgyd rviftgqfvn gtsqvhsecg lilntnaelc qyldnrdqeg
      241 fycvrpqhmp caalthmysk nkkvsylskq ekslfersnv gveimekfnt isvskcnket
      301 vamkekckfg mtstipsghv wrntwnpvsc slatvkmkec lrgkliylmg dstirqwmey
      361 fkasintlks vdlhesgklq hqlavdldrn iniqwqkycy pligsmtysv kemeyltrai
      421 drtggekntv ivislgqhfr pfpidvfirr alnvhkaiqh lllrspdtmv iiktenirem
      481 yndaerfsdf hgyiqyliik difqdlsvsi idawditiay gtnnvhppqh vvgnqinill
      541 nyic
//
LOCUS       XP_054225161             544 aa            linear   PRI 05-AUG-2025
DEFINITION  NXPE family member 4 isoform X1 [Homo sapiens].
ACCESSION   XP_054225161
VERSION     XP_054225161.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369186.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..544
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..544
                     /product="NXPE family member 4 isoform X1"
                     /calculated_mol_wt=62132
     Region          <121..259
                     /region_name="Neurexophilin"
                     /note="pfam06312"
                     /db_xref="CDD:428882"
     CDS             1..544
                     /gene="NXPE4"
                     /gene_synonym="C11orf33; FAM55D"
                     /coded_by="XM_054369186.1:484..2118"
                     /db_xref="GeneID:54827"
                     /db_xref="HGNC:HGNC:23117"
                     /db_xref="MIM:618133"
ORIGIN      
        1 mkisminyks llallfilas wiiftvfqns tkvwsalnls islhywnnst kslfpktpli
       61 slkpltetel rikeiiekld qqipprpfth vntttsaths tatilnprdt ycrgdqlhil
      121 levrdhlgrr kqyggdflra rmsspalmag asgkvtdfnn gtylvsftlf wegqvslsll
      181 lihpsegvsa lwsarnqgyd rviftgqfvn gtsqvhsecg lilntnaelc qyldnrdqeg
      241 fycvrpqhmp caalthmysk nkkvsylskq ekslfersnv gveimekfnt isvskcnket
      301 vamkekckfg mtstipsghv wrntwnpvsc slatvkmkec lrgkliylmg dstirqwmey
      361 fkasintlks vdlhesgklq hqlavdldrn iniqwqkycy pligsmtysv kemeyltrai
      421 drtggekntv ivislgqhfr pfpidvfirr alnvhkaiqh lllrspdtmv iiktenirem
      481 yndaerfsdf hgyiqyliik difqdlsvsi idawditiay gtnnvhppqh vvgnqinill
      541 nyic
//
LOCUS       XP_054225162             475 aa            linear   PRI 05-AUG-2025
DEFINITION  NXPE family member 4 isoform X2 [Homo sapiens].
ACCESSION   XP_054225162
VERSION     XP_054225162.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369187.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..475
                     /product="NXPE family member 4 isoform X2"
                     /calculated_mol_wt=54188
     Region          <121..259
                     /region_name="Neurexophilin"
                     /note="pfam06312"
                     /db_xref="CDD:428882"
     CDS             1..475
                     /gene="NXPE4"
                     /gene_synonym="C11orf33; FAM55D"
                     /coded_by="XM_054369187.1:206..1633"
                     /db_xref="GeneID:54827"
                     /db_xref="HGNC:HGNC:23117"
                     /db_xref="MIM:618133"
ORIGIN      
        1 mkisminyks llallfilas wiiftvfqns tkvwsalnls islhywnnst kslfpktpli
       61 slkpltetel rikeiiekld qqipprpfth vntttsaths tatilnprdt ycrgdqlhil
      121 levrdhlgrr kqyggdflra rmsspalmag asgkvtdfnn gtylvsftlf wegqvslsll
      181 lihpsegvsa lwsarnqgyd rviftgqfvn gtsqvhsecg lilntnaelc qyldnrdqeg
      241 fycvrpqhmp caalthmysk nkkvsylskq ekslfersnv gveimekfnt isvskcntlk
      301 svdlhesgkl qhqlavdldr niniqwqkyc ypligsmtys vkemeyltra idrtggeknt
      361 vivislgqhf rpfpidvfir ralnvhkaiq hlllrspdtm viiktenire myndaerfsd
      421 fhgyiqylii kdifqdlsvs iidawditia ygtnnvhppq hvvgnqinil lnyic
//
LOCUS       XP_054225163             319 aa            linear   PRI 05-AUG-2025
DEFINITION  NXPE family member 4 isoform X3 [Homo sapiens].
ACCESSION   XP_054225163
VERSION     XP_054225163.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369188.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..319
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..319
                     /product="NXPE family member 4 isoform X3"
                     /calculated_mol_wt=35760
     Region          <121..259
                     /region_name="Neurexophilin"
                     /note="pfam06312"
                     /db_xref="CDD:428882"
     CDS             1..319
                     /gene="NXPE4"
                     /gene_synonym="C11orf33; FAM55D"
                     /coded_by="XM_054369188.1:206..1165"
                     /db_xref="GeneID:54827"
                     /db_xref="HGNC:HGNC:23117"
                     /db_xref="MIM:618133"
ORIGIN      
        1 mkisminyks llallfilas wiiftvfqns tkvwsalnls islhywnnst kslfpktpli
       61 slkpltetel rikeiiekld qqipprpfth vntttsaths tatilnprdt ycrgdqlhil
      121 levrdhlgrr kqyggdflra rmsspalmag asgkvtdfnn gtylvsftlf wegqvslsll
      181 lihpsegvsa lwsarnqgyd rviftgqfvn gtsqvhsecg lilntnaelc qyldnrdqeg
      241 fycvrpqhmp caalthmysk nkkvsylskq ekslfersnv gveimekfnt isvskcnils
      301 alcssglskv gqdtsylge
//
LOCUS       XP_054225164             311 aa            linear   PRI 05-AUG-2025
DEFINITION  NXPE family member 4 isoform X4 [Homo sapiens].
ACCESSION   XP_054225164
VERSION     XP_054225164.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369189.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..311
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..311
                     /product="NXPE family member 4 isoform X4"
                     /calculated_mol_wt=35190
     Region          <121..259
                     /region_name="Neurexophilin"
                     /note="pfam06312"
                     /db_xref="CDD:428882"
     CDS             1..311
                     /gene="NXPE4"
                     /gene_synonym="C11orf33; FAM55D"
                     /coded_by="XM_054369189.1:206..1141"
                     /db_xref="GeneID:54827"
                     /db_xref="HGNC:HGNC:23117"
                     /db_xref="MIM:618133"
ORIGIN      
        1 mkisminyks llallfilas wiiftvfqns tkvwsalnls islhywnnst kslfpktpli
       61 slkpltetel rikeiiekld qqipprpfth vntttsaths tatilnprdt ycrgdqlhil
      121 levrdhlgrr kqyggdflra rmsspalmag asgkvtdfnn gtylvsftlf wegqvslsll
      181 lihpsegvsa lwsarnqgyd rviftgqfvn gtsqvhsecg lilntnaelc qyldnrdqeg
      241 fycvrpqhmp caalthmysk nkkvsylskq ekslfersnv gveimekfnt isvskcnryl
      301 edrgllihtd g
//
LOCUS       XP_054225165            2211 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-like protein 2 isoform X1 [Homo sapiens].
ACCESSION   XP_054225165
VERSION     XP_054225165.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369190.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2211
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2211
                     /product="synaptotagmin-like protein 2 isoform X1"
                     /calculated_mol_wt=245809
     Region          5..>41
                     /region_name="PHD_SF"
                     /note="PHD finger superfamily; cl22851"
                     /db_xref="CDD:473978"
     Region          1906..2033
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     Region          2046..2202
                     /region_name="C2B_SLP_1-2-3-4"
                     /note="C2 domain second repeat present in
                     Synaptotagmin-like proteins 1-4; cd04020"
                     /db_xref="CDD:175987"
     CDS             1..2211
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; PPP1R151; SGA72M; SLP2;
                     SLP2A"
                     /coded_by="XM_054369190.1:578..7213"
                     /db_xref="GeneID:54843"
                     /db_xref="HGNC:HGNC:15585"
                     /db_xref="MIM:612880"
ORIGIN      
        1 midlsfltee eqeaimkvlq rdaalkraee ervrhlpeki kddqqlknms gqwfyeakak
       61 rhrdkihgad iirasmrkkr pqiaelagvv eepeedaapa spsssvvnpa ssvidmsqen
      121 trkpnvspek rknpfnsskl peghssqqtk neqskngrtg lfqtskedel seskekstva
      181 dtsiqkleks kqtlpglsng sqikapipka rkmiykstdl nkddnqsfpr qrtdslkarg
      241 aprgilkrns sssstdsetl rynhnfepks kivspgltih erisekehsl ednsspnsle
      301 plkhvrfsav kdelpqspgl ihgrevgefs vlesdrlkng medagdteef qsdpkpsqyr
      361 kpslfhqsts spyvskseth qpmtsgsfpi nglhshsevl tarpqsmens ptinepkdks
      421 seltrlesvl prspadelsh cvepepsqvp ggssrdrqqg kppplpalka ktssrsgpya
      481 teikkstdds ifkvldwfnr ssysddnksf lqhprgiesk ektdsksqva vdlvtddttl
      541 rengsktlsp skielkpvrs dspfqaegdm lvsescqdnn vnikskfmnl sqkgtpkegp
      601 gilqpfesyg tpsqgsknmd ysqdskspgk gngaspsnsn ysysvlkesd aenqvpcntn
      661 nignlgeeep kfhaheenrg hsevnfdsst vvkepglkdn mnaerkskvg ntyilkasle
      721 penikstpgv anngspwkkp evqfqqeage vpknqvqrek ykrvsdrisf wegekagaki
      781 thekptsscs qeqpsakayq pvkksqgvss mdslstdqse ynqaipkrvv ldeddqasql
      841 snsyssnksk etkpqiagps ryylsaeqsd kvslfqnkkn epikrsqvad slpsrrnitl
      901 palqppsnvg serhaplekd rplvresnan fkvmslkerm depnaeqvyn psqfenlrkf
      961 wdleansnsk dndknittts qknsapfnrq khkefsdikl sgkntheaev llspkkvmar
     1021 eemeklnskg ilqvlpdeit fplsplrkyt yqlpgnessk envekntegi vtpvfkeekd
     1081 yseqeiqesi iktnvlskdc kdtfndslqk llsetstpai qpsggkvhgk qvlepsvsen
     1141 rtwpqktdfg dteeevkgpe kiinehvdkt vvhpkvkrns ltasldkllk eatgtspspl
     1201 qaklapvitg tnskleegrf fgkgieqshn tsadkreila pfpvrdetfg ntallkkaes
     1261 gecqlstqnl iqvaaedshp ldptsqlsrk gsfgdvaspp qdmlfpqgah lvpqarvhps
     1321 qmeisetvek vilpprpvln dvsaalqklc gevwlsypag revgpgevnp efpeavqpvc
     1381 splnppgvis pwatmdtivp drkdfyssnv vpdkthevgs ylaaqmspsd qtlssfasiv
     1441 aqygkglpqe veeivretiv qpkseflefs aglekllkee tetfpskyes dtgnlspskl
     1501 igsteeprra tsechpeelk etvekaeapl itesafdagf ekllkeitea ppyqpqvsvr
     1561 eethekessq seqtrflgtv phfyraasqt semkdksngl esqvnqcdkm lggdalvtdl
     1621 lvdfcgsrsg veiprtpqly vaheigtikt vtppedrdse sgvaggqgtl qepgfgease
     1681 aisvsrnrqp ipllmnkens tktskveltl aspymkqeke eekegfsesd fsdgntssna
     1741 eswrnpssse eepspvlktl ersaarkmps ksledissds snqakvdnqp eelvrsaedd
     1801 ekpdqkpvtn ecvpristvp tqpdnpfshp dklkrmsksv paflqdesdd retdtasess
     1861 yqlsrhkksp ssltnlssss gmtslssvsg svmsvysgdf gnlevkgniq faieyveslk
     1921 elhvfvaqck dlaaadvkkq rsdpyvkayl lpdkgkmgkk ktlvvkktln pvyneilryk
     1981 iekqilktqk lnlsiwhrdt fkrnsflgev eldletwdwd nkqnkqlrwy plkrktapva
     2041 leaenrgemk lalqyvpepv pgkklpttge vhiwvkecld lpllrgshln sfvkctilpd
     2101 tsrksrqktr avgkttnpif nhtmvydgfr pedlmeacve ltvwdhyklt nqflgglrig
     2161 fgtgksygte vdwmdstsee valwekmvns pntwieatlp lrmlliakis k
//
LOCUS       XP_054225166            2199 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-like protein 2 isoform X2 [Homo sapiens].
ACCESSION   XP_054225166
VERSION     XP_054225166.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369191.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2199
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2199
                     /product="synaptotagmin-like protein 2 isoform X2"
                     /calculated_mol_wt=244729
     Region          5..>51
                     /region_name="PHD_SF"
                     /note="PHD finger superfamily; cl22851"
                     /db_xref="CDD:473978"
     Region          1894..2021
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     Region          2034..2190
                     /region_name="C2B_SLP_1-2-3-4"
                     /note="C2 domain second repeat present in
                     Synaptotagmin-like proteins 1-4; cd04020"
                     /db_xref="CDD:175987"
     CDS             1..2199
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; PPP1R151; SGA72M; SLP2;
                     SLP2A"
                     /coded_by="XM_054369191.1:578..7177"
                     /db_xref="GeneID:54843"
                     /db_xref="HGNC:HGNC:15585"
                     /db_xref="MIM:612880"
ORIGIN      
        1 midlsfltee eqeaimkvlq rdaalkraee ervrhlpeki kddqqlknms gqwfyeakak
       61 rhrdkihgad iirasmrkkr pqiaaeqskd rengakeswv nnvnkdaflp pelagvveep
      121 eedaapasps ssvvnpassv idmsqentrk pnvspekqrk npfnssklpe ghssqqtkne
      181 qskngrtglf qtskedelse skekstvadt siqklekskq tlpglsngsq ikapipkark
      241 miykstdlnk ddnqsfprqr tdslkargap rgilkrnsss sstdsetlry nhnfepkski
      301 vspgltiher isekehsled nsspnslepl khvrfsavkd elpqspglih grevgefsvl
      361 esdrlkngme dagdteefqs dpkpsqyrkp slfhqstssp yvsksethqp mtsgsfping
      421 lhshsevlta rpqsmenspt inepkdksse ltrlesvlpr spadelshcv epepsqvpgg
      481 ssrdrqqgkp pplpalkakt ssrsgpyate ikkstddsif kvldwfnrss ysddnksflq
      541 hprgieskek tdsksqvavd lvtddttlre ngsktlspsk ielkpvrsds pfqaegdmlv
      601 sescqdnnvn ikskfmnlsq kgtpkegpgi lqpfesygtp sqgsknmdys qdskspgkgn
      661 gaspsnsnys ysvlkesdae nqvpcntnni gnlgeeepkf haheenrghs evnfdsstvv
      721 kepglkdnmn aerkskvgnt yilkaslepe nikstpgvan ngspwkkpev qfqqeagevp
      781 knqvqrekyk rvsdrisfwe gekagakith ekptsscsqe qpsakayqpv kksqgvssmd
      841 slstdqseyn qaipkrvvld eddqasqlsn syssnksket kpqiagpsry ylsaeqsdkv
      901 slfqnkknep ikrsqvadsl psrrnitlpa lqppsnvgse rhaplekdrp lvresnanfk
      961 vmslkermde pnaeqvynps qfenlrkfwd leansnskdn dknitttsqk nsapfnrqkh
     1021 kefsdiklsg kntheaevll spkkvmaree meklnskgil qvlpdeitfp lsplrkytyq
     1081 lpgnessken vekntegivt pvfkeekdys eqeiqesiik tnvlskdckd tfndslqkll
     1141 setstpaiqp sggkvhgkqv lepsvsenrt wpqktdfgdt eeevkgpeki inehvdktvv
     1201 hpkvkrnslt asldkllkea tgtspsplqa klapvitgtn skleegrffg kgieqshnts
     1261 adkreilapf pvrdetfgnt allkkaesge cqlstqnliq vaaedshpld ptsqlsrkgs
     1321 fgdvasppqd mlfpqgahlv pqarvhpsqm eisetvekvi lpprpvlndv saalqklcge
     1381 vwlsypagre vgpgevnpef peavqpvcsp lnppgvispw atmdtivpdr kdfyssnvvp
     1441 dkthevgsyl aaqmspsdqt lssfasivaq ygkglpqeve eivretivqp kseflefsag
     1501 lekllkeete tfpskyesdt gnlspsklig steeprrats echpeelket vekaeaplit
     1561 esafdagfek llkeiteapp yqpqvsvree thekessqse qtrflgtvph fyraasqtse
     1621 mkdksngles qvnqcdkmlg gdalvtdllv dfcgsrsgve iprtpqlyva heigtiktvt
     1681 ppedrdsesg vaggqgtlqe pgfgeaseai svsrnrqpip llmnkenstk tskveltlas
     1741 pymkqekeee kegfsesdfs dgntssnaes wrnpssseee pspvlktler saarkmpsks
     1801 ledissdssn qakvdnqpee lvrsaeddek pdqkpvtnec vpristvptq pdnpfshpdk
     1861 lkrmsksvpa flqdevsgsv msvysgdfgn levkgniqfa ieyveslkel hvfvaqckdl
     1921 aaadvkkqrs dpyvkayllp dkgkmgkkkt lvvkktlnpv yneilrykie kqilktqkln
     1981 lsiwhrdtfk rnsflgevel dletwdwdnk qnkqlrwypl krktapvale aenrgemkla
     2041 lqyvpepvpg kklpttgevh iwvkecldlp llrgshlnsf vkctilpdts rksrqktrav
     2101 gkttnpifnh tmvydgfrpe dlmeacvelt vwdhykltnq flgglrigfg tgksygtevd
     2161 wmdstseeva lwekmvnspn twieatlplr mlliakisk
//
LOCUS       XP_054225167            2198 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-like protein 2 isoform X3 [Homo sapiens].
ACCESSION   XP_054225167
VERSION     XP_054225167.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369192.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2198
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2198
                     /product="synaptotagmin-like protein 2 isoform X3"
                     /calculated_mol_wt=244600
     Region          5..>51
                     /region_name="PHD_SF"
                     /note="PHD finger superfamily; cl22851"
                     /db_xref="CDD:473978"
     Region          1893..2020
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     Region          2033..2189
                     /region_name="C2B_SLP_1-2-3-4"
                     /note="C2 domain second repeat present in
                     Synaptotagmin-like proteins 1-4; cd04020"
                     /db_xref="CDD:175987"
     CDS             1..2198
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; PPP1R151; SGA72M; SLP2;
                     SLP2A"
                     /coded_by="XM_054369192.1:578..7174"
                     /db_xref="GeneID:54843"
                     /db_xref="HGNC:HGNC:15585"
                     /db_xref="MIM:612880"
ORIGIN      
        1 midlsfltee eqeaimkvlq rdaalkraee ervrhlpeki kddqqlknms gqwfyeakak
       61 rhrdkihgad iirasmrkkr pqiaaeqskd rengakeswv nnvnkdaflp pelagvveep
      121 eedaapasps ssvvnpassv idmsqentrk pnvspekrkn pfnssklpeg hssqqtkneq
      181 skngrtglfq tskedelses kekstvadts iqklekskqt lpglsngsqi kapipkarkm
      241 iykstdlnkd dnqsfprqrt dslkargapr gilkrnssss stdsetlryn hnfepkskiv
      301 spgltiheri sekehsledn sspnsleplk hvrfsavkde lpqspglihg revgefsvle
      361 sdrlkngmed agdteefqsd pkpsqyrkps lfhqstsspy vsksethqpm tsgsfpingl
      421 hshsevltar pqsmenspti nepkdkssel trlesvlprs padelshcve pepsqvpggs
      481 srdrqqgkpp plpalkakts srsgpyatei kkstddsifk vldwfnrssy sddnksflqh
      541 prgieskekt dsksqvavdl vtddttlren gsktlspski elkpvrsdsp fqaegdmlvs
      601 escqdnnvni kskfmnlsqk gtpkegpgil qpfesygtps qgsknmdysq dskspgkgng
      661 aspsnsnysy svlkesdaen qvpcntnnig nlgeeepkfh aheenrghse vnfdsstvvk
      721 epglkdnmna erkskvgnty ilkaslepen ikstpgvann gspwkkpevq fqqeagevpk
      781 nqvqrekykr vsdrisfweg ekagakithe kptsscsqeq psakayqpvk ksqgvssmds
      841 lstdqseynq aipkrvvlde ddqasqlsns yssnksketk pqiagpsryy lsaeqsdkvs
      901 lfqnkknepi krsqvadslp srrnitlpal qppsnvgser haplekdrpl vresnanfkv
      961 mslkermdep naeqvynpsq fenlrkfwdl eansnskdnd knitttsqkn sapfnrqkhk
     1021 efsdiklsgk ntheaevlls pkkvmareem eklnskgilq vlpdeitfpl splrkytyql
     1081 pgnesskenv ekntegivtp vfkeekdyse qeiqesiikt nvlskdckdt fndslqklls
     1141 etstpaiqps ggkvhgkqvl epsvsenrtw pqktdfgdte eevkgpekii nehvdktvvh
     1201 pkvkrnslta sldkllkeat gtspsplqak lapvitgtns kleegrffgk gieqshntsa
     1261 dkreilapfp vrdetfgnta llkkaesgec qlstqnliqv aaedshpldp tsqlsrkgsf
     1321 gdvasppqdm lfpqgahlvp qarvhpsqme isetvekvil pprpvlndvs aalqklcgev
     1381 wlsypagrev gpgevnpefp eavqpvcspl nppgvispwa tmdtivpdrk dfyssnvvpd
     1441 kthevgsyla aqmspsdqtl ssfasivaqy gkglpqevee ivretivqpk seflefsagl
     1501 ekllkeetet fpskyesdtg nlspskligs teeprratse chpeelketv ekaeaplite
     1561 safdagfekl lkeiteappy qpqvsvreet hekessqseq trflgtvphf yraasqtsem
     1621 kdksnglesq vnqcdkmlgg dalvtdllvd fcgsrsgvei prtpqlyvah eigtiktvtp
     1681 pedrdsesgv aggqgtlqep gfgeaseais vsrnrqpipl lmnkenstkt skveltlasp
     1741 ymkqekeeek egfsesdfsd gntssnaesw rnpssseeep spvlktlers aarkmpsksl
     1801 edissdssnq akvdnqpeel vrsaeddekp dqkpvtnecv pristvptqp dnpfshpdkl
     1861 krmsksvpaf lqdevsgsvm svysgdfgnl evkgniqfai eyveslkelh vfvaqckdla
     1921 aadvkkqrsd pyvkayllpd kgkmgkkktl vvkktlnpvy neilrykiek qilktqklnl
     1981 siwhrdtfkr nsflgeveld letwdwdnkq nkqlrwyplk rktapvalea enrgemklal
     2041 qyvpepvpgk klpttgevhi wvkecldlpl lrgshlnsfv kctilpdtsr ksrqktravg
     2101 kttnpifnht mvydgfrped lmeacveltv wdhykltnqf lgglrigfgt gksygtevdw
     2161 mdstseeval wekmvnspnt wieatlplrm lliakisk
//
LOCUS       XP_054225168            2191 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-like protein 2 isoform X27 [Homo sapiens].
ACCESSION   XP_054225168
VERSION     XP_054225168.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369193.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2191
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2191
                     /product="synaptotagmin-like protein 2 isoform X27"
                     /calculated_mol_wt=243244
     Region          1886..2013
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     Region          2026..2182
                     /region_name="C2B_SLP_1-2-3-4"
                     /note="C2 domain second repeat present in
                     Synaptotagmin-like proteins 1-4; cd04020"
                     /db_xref="CDD:175987"
     CDS             1..2191
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; PPP1R151; SGA72M; SLP2;
                     SLP2A"
                     /coded_by="XM_054369193.1:232..6807"
                     /db_xref="GeneID:54843"
                     /db_xref="HGNC:HGNC:15585"
                     /db_xref="MIM:612880"
ORIGIN      
        1 msgqwfyeak akrhrdkihg adiirasmrk krpqiaaeqs kdrengakes wvnnvnkdaf
       61 lppelagvve epeedaapas psssvvnpas svidmsqent rkpnvspekq rknpfnsskl
      121 peghssqqtk neqskngrtg lfqtskedel seskekstva dtsiqkleks kqtlpglsng
      181 sqikapipka rkmiykstdl nkddnqsfpr qrtdslkarg aprgilkrns sssstdsetl
      241 rynhnfepks kivspgltih erisekehsl ednsspnsle plkhvrfsav kdelpqspgl
      301 ihgrevgefs vlesdrlkng medagdteef qsdpkpsqyr kpslfhqsts spyvskseth
      361 qpmtsgsfpi nglhshsevl tarpqsmens ptinepkdks seltrlesvl prspadelsh
      421 cvepepsqvp ggssrdrqqg kppplpalka ktssrsgpya teikkstdds ifkvldwfnr
      481 ssysddnksf lqhprgiesk ektdsksqva vdlvtddttl rengsktlsp skielkpvrs
      541 dspfqaegdm lvsescqdnn vnikskfmnl sqkgtpkegp gilqpfesyg tpsqgsknmd
      601 ysqdskspgk gngaspsnsn ysysvlkesd aenqvpcntn nignlgeeep kfhaheenrg
      661 hsevnfdsst vvkepglkdn mnaerkskvg ntyilkasle penikstpgv anngspwkkp
      721 evqfqqeage vpknqvqrek ykrvsdrisf wegekagaki thekptsscs qeqpsakayq
      781 pvkksqgvss mdslstdqse ynqaipkrvv ldeddqasql snsyssnksk etkpqiagps
      841 ryylsaeqsd kvslfqnkkn epikrsqvad slpsrrnitl palqppsnvg serhaplekd
      901 rplvresnan fkvmslkerm depnaeqvyn psqfenlrkf wdleansnsk dndknittts
      961 qknsapfnrq khkefsdikl sgkntheaev llspkkvmar eemeklnskg ilqvlpdeit
     1021 fplsplrkyt yqlpgnessk envekntegi vtpvfkeekd yseqeiqesi iktnvlskdc
     1081 kdtfndslqk llsetstpai qpsggkvhgk qvlepsvsen rtwpqktdfg dteeevkgpe
     1141 kiinehvdkt vvhpkvkrns ltasldkllk eatgtspspl qaklapvitg tnskleegrf
     1201 fgkgieqshn tsadkreila pfpvrdetfg ntallkkaes gecqlstqnl iqvaaedshp
     1261 ldptsqlsrk gsfgdvaspp qdmlfpqgah lvpqarvhps qmeisetvek vilpprpvln
     1321 dvsaalqklc gevwlsypag revgpgevnp efpeavqpvc splnppgvis pwatmdtivp
     1381 drkdfyssnv vpdkthevgs ylaaqmspsd qtlssfasiv aqygkglpqe veeivretiv
     1441 qpkseflefs aglekllkee tetfpskyes dtgnlspskl igsteeprra tsechpeelk
     1501 etvekaeapl itesafdagf ekllkeitea ppyqpqvsvr eethekessq seqtrflgtv
     1561 phfyraasqt semkdksngl esqvnqcdkm lggdalvtdl lvdfcgsrsg veiprtpqly
     1621 vaheigtikt vtppedrdse sgvaggqgtl qepgfgease aisvsrnrqp ipllmnkens
     1681 tktskveltl aspymkqeke eekegfsesd fsdgntssna eswrnpssse eepspvlktl
     1741 ersaarkmps ksledissds snqakvdnqp eelvrsaedd ekpdqkpvtn ecvpristvp
     1801 tqpdnpfshp dklkrmsksv paflqdesdd retdtasess yqlsrhkksp ssltnlssss
     1861 gmtslssvsg svmsvysgdf gnlevkgniq faieyveslk elhvfvaqck dlaaadvkkq
     1921 rsdpyvkayl lpdkgkmgkk ktlvvkktln pvyneilryk iekqilktqk lnlsiwhrdt
     1981 fkrnsflgev eldletwdwd nkqnkqlrwy plkrktapva leaenrgemk lalqyvpepv
     2041 pgkklpttge vhiwvkecld lpllrgshln sfvkctilpd tsrksrqktr avgkttnpif
     2101 nhtmvydgfr pedlmeacve ltvwdhyklt nqflgglrig fgtgksygte vdwmdstsee
     2161 valwekmvns pntwieatlp lrmlliakis k
//
LOCUS       XP_054225169            2190 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-like protein 2 isoform X28 [Homo sapiens].
ACCESSION   XP_054225169
VERSION     XP_054225169.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369194.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2190
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2190
                     /product="synaptotagmin-like protein 2 isoform X28"
                     /calculated_mol_wt=243116
     Region          1885..2012
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     Region          2025..2181
                     /region_name="C2B_SLP_1-2-3-4"
                     /note="C2 domain second repeat present in
                     Synaptotagmin-like proteins 1-4; cd04020"
                     /db_xref="CDD:175987"
     CDS             1..2190
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; PPP1R151; SGA72M; SLP2;
                     SLP2A"
                     /coded_by="XM_054369194.1:232..6804"
                     /db_xref="GeneID:54843"
                     /db_xref="HGNC:HGNC:15585"
                     /db_xref="MIM:612880"
ORIGIN      
        1 msgqwfyeak akrhrdkihg adiirasmrk krpqiaaeqs kdrengakes wvnnvnkdaf
       61 lppelagvve epeedaapas psssvvnpas svidmsqent rkpnvspekr knpfnssklp
      121 eghssqqtkn eqskngrtgl fqtskedels eskekstvad tsiqkleksk qtlpglsngs
      181 qikapipkar kmiykstdln kddnqsfprq rtdslkarga prgilkrnss ssstdsetlr
      241 ynhnfepksk ivspgltihe risekehsle dnsspnslep lkhvrfsavk delpqspgli
      301 hgrevgefsv lesdrlkngm edagdteefq sdpkpsqyrk pslfhqstss pyvsksethq
      361 pmtsgsfpin glhshsevlt arpqsmensp tinepkdkss eltrlesvlp rspadelshc
      421 vepepsqvpg gssrdrqqgk ppplpalkak tssrsgpyat eikkstddsi fkvldwfnrs
      481 sysddnksfl qhprgieske ktdsksqvav dlvtddttlr engsktlsps kielkpvrsd
      541 spfqaegdml vsescqdnnv nikskfmnls qkgtpkegpg ilqpfesygt psqgsknmdy
      601 sqdskspgkg ngaspsnsny sysvlkesda enqvpcntnn ignlgeeepk fhaheenrgh
      661 sevnfdsstv vkepglkdnm naerkskvgn tyilkaslep enikstpgva nngspwkkpe
      721 vqfqqeagev pknqvqreky krvsdrisfw egekagakit hekptsscsq eqpsakayqp
      781 vkksqgvssm dslstdqsey nqaipkrvvl deddqasqls nsyssnkske tkpqiagpsr
      841 yylsaeqsdk vslfqnkkne pikrsqvads lpsrrnitlp alqppsnvgs erhaplekdr
      901 plvresnanf kvmslkermd epnaeqvynp sqfenlrkfw dleansnskd ndknitttsq
      961 knsapfnrqk hkefsdikls gkntheaevl lspkkvmare emeklnskgi lqvlpdeitf
     1021 plsplrkyty qlpgnesske nvekntegiv tpvfkeekdy seqeiqesii ktnvlskdck
     1081 dtfndslqkl lsetstpaiq psggkvhgkq vlepsvsenr twpqktdfgd teeevkgpek
     1141 iinehvdktv vhpkvkrnsl tasldkllke atgtspsplq aklapvitgt nskleegrff
     1201 gkgieqshnt sadkreilap fpvrdetfgn tallkkaesg ecqlstqnli qvaaedshpl
     1261 dptsqlsrkg sfgdvasppq dmlfpqgahl vpqarvhpsq meisetvekv ilpprpvlnd
     1321 vsaalqklcg evwlsypagr evgpgevnpe fpeavqpvcs plnppgvisp watmdtivpd
     1381 rkdfyssnvv pdkthevgsy laaqmspsdq tlssfasiva qygkglpqev eeivretivq
     1441 pkseflefsa glekllkeet etfpskyesd tgnlspskli gsteeprrat sechpeelke
     1501 tvekaeapli tesafdagfe kllkeiteap pyqpqvsvre ethekessqs eqtrflgtvp
     1561 hfyraasqts emkdksngle sqvnqcdkml ggdalvtdll vdfcgsrsgv eiprtpqlyv
     1621 aheigtiktv tppedrdses gvaggqgtlq epgfgeasea isvsrnrqpi pllmnkenst
     1681 ktskveltla spymkqekee ekegfsesdf sdgntssnae swrnpsssee epspvlktle
     1741 rsaarkmpsk sledissdss nqakvdnqpe elvrsaedde kpdqkpvtne cvpristvpt
     1801 qpdnpfshpd klkrmsksvp aflqdesddr etdtasessy qlsrhkksps sltnlssssg
     1861 mtslssvsgs vmsvysgdfg nlevkgniqf aieyveslke lhvfvaqckd laaadvkkqr
     1921 sdpyvkayll pdkgkmgkkk tlvvkktlnp vyneilryki ekqilktqkl nlsiwhrdtf
     1981 krnsflgeve ldletwdwdn kqnkqlrwyp lkrktapval eaenrgemkl alqyvpepvp
     2041 gkklpttgev hiwvkecldl pllrgshlns fvkctilpdt srksrqktra vgkttnpifn
     2101 htmvydgfrp edlmeacvel tvwdhykltn qflgglrigf gtgksygtev dwmdstseev
     2161 alwekmvnsp ntwieatlpl rmlliakisk
//
LOCUS       XP_054225170            2182 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-like protein 2 isoform X4 [Homo sapiens].
ACCESSION   XP_054225170
VERSION     XP_054225170.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369195.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2182
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2182
                     /product="synaptotagmin-like protein 2 isoform X4"
                     /calculated_mol_wt=242749
     Region          5..>51
                     /region_name="PHD_SF"
                     /note="PHD finger superfamily; cl22851"
                     /db_xref="CDD:473978"
     Region          1877..2004
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     Region          2017..2173
                     /region_name="C2B_SLP_1-2-3-4"
                     /note="C2 domain second repeat present in
                     Synaptotagmin-like proteins 1-4; cd04020"
                     /db_xref="CDD:175987"
     CDS             1..2182
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; PPP1R151; SGA72M; SLP2;
                     SLP2A"
                     /coded_by="XM_054369195.1:578..7126"
                     /db_xref="GeneID:54843"
                     /db_xref="HGNC:HGNC:15585"
                     /db_xref="MIM:612880"
ORIGIN      
        1 midlsfltee eqeaimkvlq rdaalkraee ervrhlpeki kddqqlknms gqwfyeakak
       61 rhrdkihgad iirasmrkkr pqiaaeqskd rengakeswv nnvnkdaflp pelagvveep
      121 eedaapasps ssvvnpassv idmsqentrk pnvspekrkn pfnssklpeg hssqqtkneq
      181 skngrtglfq tskedelses kekstvadts iqklekskqt lpglsngsqi kapipkarkm
      241 iykstdlnkd dnqsfprqrt dslkargapr gilkrnssss stdsetlryn hnfepkskiv
      301 spgltiheri sekehsledn sspnsleplk hvrfsavkde lpqspglihg revgefsvle
      361 sdrlkngmed agdteefqsd pkpsqyrkps lfhqstsspy vsksethqpm tsgsfpingl
      421 hshsevltar pqsmenspti nepkdkssel trlesvlprs padelshcve pepsqvpggs
      481 srdrqqgkpp plpalkakts srsgpyatei kkstddsifk vldwfnrssy sddnksflqh
      541 prgieskekt dsksqvavdl vtddttlren gsktlspski elkpvrsdsp fqaegdmlvs
      601 escqdnnvni kskfmnlsqk gtpkegpgil qpfesygtps qgsknmdysq dskspgkgng
      661 aspsnsnysy svlkesdaen qvpcntnnig nlgeeepkfh aheenrghse vnfdsstvvk
      721 epglkdnmna erkskvgnty ilkaslepen ikstpgvann gspwkkpevq fqqeagevpk
      781 nqvqrekykr vsdrisfweg ekagakithe kptsscsqeq psakayqpvk ksqgvssmds
      841 lstdqseynq aipkrvvlde ddqasqlsns yssnksketk pqiagpsryy lsaeqsdkvs
      901 lfqnkknepi krsqvadslp srrnitlpal qppsnvgser haplekdrpl vresnanfkv
      961 mslkermdep naeqvynpsq fenlrkfwdl eansnskdnd knitttsqkn sapfnrqkhk
     1021 efsdiklsgk ntheaevlls pkkvmareem eklnskgilq vlpdeitfpl splrkytyql
     1081 pgnesskenv ekntegivtp vfkeekdyse qeiqesiikt nvlskdckdt fndslqklls
     1141 etstpaiqps ggkvhgkqvl epsvsenrtw pqktdfgdte eevkgpekii nehvdktvvh
     1201 pkvkrnslta sldkllkeat gtspsplqak lapvitgtns kleegrffgk gieqshntsa
     1261 dkreilapfp vrdetfgnta llkkaesgec qlstqnliqv aaedshpldp tsqlsrkgsf
     1321 gdvasppqdm lfpqgahlvp qarvhpsqme isetvekvil pprpvlndvs aalqklcgev
     1381 wlsypagrev gpgevnpefp eavqpvcspl nppgvispwa tmdtivpdrk dfyssnvvpd
     1441 kthevgsyla aqmspsdqtl ssfasivaqy gkglpqevee ivretivqpk seflefsagl
     1501 ekllkeetet fpskyesdtg nlspskligs teeprratse chpeelketv ekaeaplite
     1561 safdagfekl lkeiteappy qpqvsvreet hekessqseq trflgtvphf yraasqtsem
     1621 kdksnglesq vnqcdkmlgg dalvtdllvd fcgsrsgvei prtpqlyvah eigtiktvtp
     1681 pedrdsesgv aggqgtlqep gfgeaseais vsrnrqpipl lmnkenstkt skveltlasp
     1741 ymkqekeeek egfsesdfsd gntssnaesw rnpssseeep spvlktlers aarkmpsksl
     1801 edissdssnq akvdnqpeel vrsaedvstv ptqpdnpfsh pdklkrmsks vpaflqdevs
     1861 gsvmsvysgd fgnlevkgni qfaieyvesl kelhvfvaqc kdlaaadvkk qrsdpyvkay
     1921 llpdkgkmgk kktlvvkktl npvyneilry kiekqilktq klnlsiwhrd tfkrnsflge
     1981 veldletwdw dnkqnkqlrw yplkrktapv aleaenrgem klalqyvpep vpgkklpttg
     2041 evhiwvkecl dlpllrgshl nsfvkctilp dtsrksrqkt ravgkttnpi fnhtmvydgf
     2101 rpedlmeacv eltvwdhykl tnqflgglri gfgtgksygt evdwmdstse evalwekmvn
     2161 spntwieatl plrmlliaki sk
//
LOCUS       XP_054225171            2182 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-like protein 2 isoform X5 [Homo sapiens].
ACCESSION   XP_054225171
VERSION     XP_054225171.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369196.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2182
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2182
                     /product="synaptotagmin-like protein 2 isoform X5"
                     /calculated_mol_wt=241761
     Region          5..>51
                     /region_name="PHD_SF"
                     /note="PHD finger superfamily; cl22851"
                     /db_xref="CDD:473978"
     Region          1934..>2006
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     Region          2017..2173
                     /region_name="C2B_SLP_1-2-3-4"
                     /note="C2 domain second repeat present in
                     Synaptotagmin-like proteins 1-4; cd04020"
                     /db_xref="CDD:175987"
     CDS             1..2182
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; PPP1R151; SGA72M; SLP2;
                     SLP2A"
                     /coded_by="XM_054369196.1:578..7126"
                     /db_xref="GeneID:54843"
                     /db_xref="HGNC:HGNC:15585"
                     /db_xref="MIM:612880"
ORIGIN      
        1 midlsfltee eqeaimkvlq rdaalkraee ervrhlpeki kddqqlknms gqwfyeakak
       61 rhrdkihgad iirasmrkkr pqiaaeqskd rengakeswv nnvnkdaflp pelagvveep
      121 eedaapasps ssvvnpassv idmsqentrk pnvspekqrk npfnssklpe ghssqqtkne
      181 qskngrtglf qtskedelse skekstvadt siqklekskq tlpglsngsq ikapipkark
      241 miykstdlnk ddnqsfprqr tdslkargap rgilkrnsss sstdsetlry nhnfepkski
      301 vspgltiher isekehsled nsspnslepl khvrfsavkd elpqspglih grevgefsvl
      361 esdrlkngme dagdteefqs dpkpsqyrkp slfhqstssp yvsksethqp mtsgsfping
      421 lhshsevlta rpqsmenspt inepkdksse ltrlesvlpr spadelshcv epepsqvpgg
      481 ssrdrqqgkp pplpalkakt ssrsgpyate ikkstddsif kvldwfnrss ysddnksflq
      541 hprgieskek tdsksqvavd lvtddttlre ngsktlspsk ielkpvrsds pfqaegdmlv
      601 sescqdnnvn ikskfmnlsq kgtpkegpgi lqpfesygtp sqgsknmdys qdskspgkgn
      661 gaspsnsnys ysvlkesdae nqvpcntnni gnlgeeepkf haheenrghs evnfdsstvv
      721 kepglkdnmn aerkskvgnt yilkaslepe nikstpgvan ngspwkkpev qfqqeagevp
      781 knqvqrekyk rvsdrisfwe gekagakith ekptsscsqe qpsakayqpv kksqgvssmd
      841 slstdqseyn qaipkrvvld eddqasqlsn syssnksket kpqiagpsry ylsaeqsdkv
      901 slfqnkknep ikrsqvadsl psrrnitlpa lqppsnvgse rhaplekdrp lvresnanfk
      961 vmslkermde pnaeqvynps qfenlrkfwd leansnskdn dknitttsqk nsapfnrqkh
     1021 kefsdiklsg kntheaevll spkkvmaree meklnskgil qvlpdeitfp lsplrkytyq
     1081 lpgnessken vekntegivt pvfkeekdys eqeiqesiik tnvlskdckd tfndslqkll
     1141 setstpaiqp sggkvhgkqv lepsvsenrt wpqktdfgdt eeevkgpeki inehvdktvv
     1201 hpkvkrnslt asldkllkea tgtspsplqa klapvitgtn skleegrffg kgieqshnts
     1261 adkreilapf pvrdetfgnt allkkaesge cqlstqnliq vaaedshpld ptsqlsrkgs
     1321 fgdvasppqd mlfpqgahlv pqarvhpsqm eisetvekvi lpprpvlndv saalqklcge
     1381 vwlsypagre vgpgevnpef peavqpvcsp lnppgvispw atmdtivpdr kdfyssnvvp
     1441 dkthevgsyl aaqmspsdqt lssfasivaq ygkglpqeve eivretivqp kseflefsag
     1501 lekllkeete tfpskyesdt gnlspsklig steeprrats echpeelket vekaeaplit
     1561 esafdagfek llkeiteapp yqpqvsvree thekessqse qtrflgtvph fyraasqtse
     1621 mkdksngles qvnqcdkmlg gdalvtdllv dfcgsrsgve iprtpqlyva heigtiktvt
     1681 ppedrdsesg vaggqgtlqe pgfgeaseai svsrnrqpip llmnkenstk tskveltlas
     1741 pymkqekeee kegfsesdfs dgntssnaes wrnpssseee pspvlktler saarkmpsks
     1801 ledissdssn qakvdnqpee lvrsaeddek pdqkpvtnec vpristvptq pdnpfshpdk
     1861 lkrmsksvpa flqdesddre tdtasessyq lsrhkkspss ltnlssssgm tslssvsgsv
     1921 msvysgdfgn levkgniqfa ieyveslkel hvfvaqckdl aaadvkkqrs dpyvkayllp
     1981 dkgkmgkkkt lvvkktlnpv yneilrtapv aleaenrgem klalqyvpep vpgkklpttg
     2041 evhiwvkecl dlpllrgshl nsfvkctilp dtsrksrqkt ravgkttnpi fnhtmvydgf
     2101 rpedlmeacv eltvwdhykl tnqflgglri gfgtgksygt evdwmdstse evalwekmvn
     2161 spntwieatl plrmlliaki sk
//
LOCUS       XP_054225172            2175 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-like protein 2 isoform X6 [Homo sapiens].
ACCESSION   XP_054225172
VERSION     XP_054225172.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369197.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2175
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2175
                     /product="synaptotagmin-like protein 2 isoform X6"
                     /calculated_mol_wt=241393
     Region          1870..1997
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     Region          2010..2166
                     /region_name="C2B_SLP_1-2-3-4"
                     /note="C2 domain second repeat present in
                     Synaptotagmin-like proteins 1-4; cd04020"
                     /db_xref="CDD:175987"
     CDS             1..2175
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; PPP1R151; SGA72M; SLP2;
                     SLP2A"
                     /coded_by="XM_054369197.1:232..6759"
                     /db_xref="GeneID:54843"
                     /db_xref="HGNC:HGNC:15585"
                     /db_xref="MIM:612880"
ORIGIN      
        1 msgqwfyeak akrhrdkihg adiirasmrk krpqiaaeqs kdrengakes wvnnvnkdaf
       61 lppelagvve epeedaapas psssvvnpas svidmsqent rkpnvspekq rknpfnsskl
      121 peghssqqtk neqskngrtg lfqtskedel seskekstva dtsiqkleks kqtlpglsng
      181 sqikapipka rkmiykstdl nkddnqsfpr qrtdslkarg aprgilkrns sssstdsetl
      241 rynhnfepks kivspgltih erisekehsl ednsspnsle plkhvrfsav kdelpqspgl
      301 ihgrevgefs vlesdrlkng medagdteef qsdpkpsqyr kpslfhqsts spyvskseth
      361 qpmtsgsfpi nglhshsevl tarpqsmens ptinepkdks seltrlesvl prspadelsh
      421 cvepepsqvp ggssrdrqqg kppplpalka ktssrsgpya teikkstdds ifkvldwfnr
      481 ssysddnksf lqhprgiesk ektdsksqva vdlvtddttl rengsktlsp skielkpvrs
      541 dspfqaegdm lvsescqdnn vnikskfmnl sqkgtpkegp gilqpfesyg tpsqgsknmd
      601 ysqdskspgk gngaspsnsn ysysvlkesd aenqvpcntn nignlgeeep kfhaheenrg
      661 hsevnfdsst vvkepglkdn mnaerkskvg ntyilkasle penikstpgv anngspwkkp
      721 evqfqqeage vpknqvqrek ykrvsdrisf wegekagaki thekptsscs qeqpsakayq
      781 pvkksqgvss mdslstdqse ynqaipkrvv ldeddqasql snsyssnksk etkpqiagps
      841 ryylsaeqsd kvslfqnkkn epikrsqvad slpsrrnitl palqppsnvg serhaplekd
      901 rplvresnan fkvmslkerm depnaeqvyn psqfenlrkf wdleansnsk dndknittts
      961 qknsapfnrq khkefsdikl sgkntheaev llspkkvmar eemeklnskg ilqvlpdeit
     1021 fplsplrkyt yqlpgnessk envekntegi vtpvfkeekd yseqeiqesi iktnvlskdc
     1081 kdtfndslqk llsetstpai qpsggkvhgk qvlepsvsen rtwpqktdfg dteeevkgpe
     1141 kiinehvdkt vvhpkvkrns ltasldkllk eatgtspspl qaklapvitg tnskleegrf
     1201 fgkgieqshn tsadkreila pfpvrdetfg ntallkkaes gecqlstqnl iqvaaedshp
     1261 ldptsqlsrk gsfgdvaspp qdmlfpqgah lvpqarvhps qmeisetvek vilpprpvln
     1321 dvsaalqklc gevwlsypag revgpgevnp efpeavqpvc splnppgvis pwatmdtivp
     1381 drkdfyssnv vpdkthevgs ylaaqmspsd qtlssfasiv aqygkglpqe veeivretiv
     1441 qpkseflefs aglekllkee tetfpskyes dtgnlspskl igsteeprra tsechpeelk
     1501 etvekaeapl itesafdagf ekllkeitea ppyqpqvsvr eethekessq seqtrflgtv
     1561 phfyraasqt semkdksngl esqvnqcdkm lggdalvtdl lvdfcgsrsg veiprtpqly
     1621 vaheigtikt vtppedrdse sgvaggqgtl qepgfgease aisvsrnrqp ipllmnkens
     1681 tktskveltl aspymkqeke eekegfsesd fsdgntssna eswrnpssse eepspvlktl
     1741 ersaarkmps ksledissds snqakvdnqp eelvrsaedv stvptqpdnp fshpdklkrm
     1801 sksvpaflqd esddretdta sessyqlsrh kkspssltnl ssssgmtsls svsgsvmsvy
     1861 sgdfgnlevk gniqfaieyv eslkelhvfv aqckdlaaad vkkqrsdpyv kayllpdkgk
     1921 mgkkktlvvk ktlnpvynei lrykiekqil ktqklnlsiw hrdtfkrnsf lgeveldlet
     1981 wdwdnkqnkq lrwyplkrkt apvaleaenr gemklalqyv pepvpgkklp ttgevhiwvk
     2041 ecldlpllrg shlnsfvkct ilpdtsrksr qktravgktt npifnhtmvy dgfrpedlme
     2101 acveltvwdh ykltnqflgg lrigfgtgks ygtevdwmds tseevalwek mvnspntwie
     2161 atlplrmlli akisk
//
LOCUS       XP_054225173            1836 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-like protein 2 isoform X7 [Homo sapiens].
ACCESSION   XP_054225173
VERSION     XP_054225173.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369198.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1836
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1836
                     /product="synaptotagmin-like protein 2 isoform X7"
                     /calculated_mol_wt=203212
     Region          5..>51
                     /region_name="PHD_SF"
                     /note="PHD finger superfamily; cl22851"
                     /db_xref="CDD:473978"
     CDS             1..1836
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; PPP1R151; SGA72M; SLP2;
                     SLP2A"
                     /coded_by="XM_054369198.1:578..6088"
                     /db_xref="GeneID:54843"
                     /db_xref="HGNC:HGNC:15585"
                     /db_xref="MIM:612880"
ORIGIN      
        1 midlsfltee eqeaimkvlq rdaalkraee ervrhlpeki kddqqlknms gqwfyeakak
       61 rhrdkihgad iirasmrkkr pqiaaeqskd rengakeswv nnvnkdaflp pelagvveep
      121 eedaapasps ssvvnpassv idmsqentrk pnvspekqrk npfnssklpe ghssqqtkne
      181 qskngrtglf qtskedelse skekstvadt siqklekskq tlpglsngsq ikapipkark
      241 miykstdlnk ddnqsfprqr tdslkargap rgilkrnsss sstdsetlry nhnfepkski
      301 vspgltiher isekehsled nsspnslepl khvrfsavkd elpqspglih grevgefsvl
      361 esdrlkngme dagdteefqs dpkpsqyrkp slfhqstssp yvsksethqp mtsgsfping
      421 lhshsevlta rpqsmenspt inepkdksse ltrlesvlpr spadelshcv epepsqvpgg
      481 ssrdrqqgkp pplpalkakt ssrsgpyate ikkstddsif kvldwfnrss ysddnksflq
      541 hprgieskek tdsksqvavd lvtddttlre ngsktlspsk ielkpvrsds pfqaegdmlv
      601 sescqdnnvn ikskfmnlsq kgtpkegpgi lqpfesygtp sqgsknmdys qdskspgkgn
      661 gaspsnsnys ysvlkesdae nqvpcntnni gnlgeeepkf haheenrghs evnfdsstvv
      721 kepglkdnmn aerkskvgnt yilkaslepe nikstpgvan ngspwkkpev qfqqeagevp
      781 knqvqrekyk rvsdrisfwe gekagakith ekptsscsqe qpsakayqpv kksqgvssmd
      841 slstdqseyn qaipkrvvld eddqasqlsn syssnksket kpqiagpsry ylsaeqsdkv
      901 slfqnkknep ikrsqvadsl psrrnitlpa lqppsnvgse rhaplekdrp lvresnanfk
      961 vmslkermde pnaeqvynps qfenlrkfwd leansnskdn dknitttsqk nsapfnrqkh
     1021 kefsdiklsg kntheaevll spkkvmaree meklnskgil qvlpdeitfp lsplrkytyq
     1081 lpgnessken vekntegivt pvfkeekdys eqeiqesiik tnvlskdckd tfndslqkll
     1141 setstpaiqp sggkvhgkqv lepsvsenrt wpqktdfgdt eeevkgpeki inehvdktvv
     1201 hpkvkrnslt asldkllkea tgtspsplqa klapvitgtn skleegrffg kgieqshnts
     1261 adkreilapf pvrdetfgnt allkkaesge cqlstqnliq vaaedshpld ptsqlsrkgs
     1321 fgdvasppqd mlfpqgahlv pqarvhpsqm eisetvekvi lpprpvlndv saalqklcge
     1381 vwlsypagre vgpgevnpef peavqpvcsp lnppgvispw atmdtivpdr kdfyssnvvp
     1441 dkthevgsyl aaqmspsdqt lssfasivaq ygkglpqeve eivretivqp kseflefsag
     1501 lekllkeete tfpskyesdt gnlspsklig steeprrats echpeelket vekaeaplit
     1561 esafdagfek llkeiteapp yqpqvsvree thekessqse qtrflgtvph fyraasqtse
     1621 mkdksngles qvnqcdkmlg gdalvtdllv dfcgsrsgve iprtpqlyva heigtiktvt
     1681 ppedrdsesg vaggqgtlqe pgfgeaseai svsrnrqpip llmnkenstk tskveltlas
     1741 pymkqekeee kegfsesdfs dgntssnaes wrnpssseee pspvlktler saarkmpsks
     1801 ledissdssn qakvdnqpee lvrsaedgew qcdecl
//
LOCUS       XP_054225174            1828 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-like protein 2 isoform X8 [Homo sapiens].
ACCESSION   XP_054225174
VERSION     XP_054225174.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369199.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1828
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1828
                     /product="synaptotagmin-like protein 2 isoform X8"
                     /calculated_mol_wt=202277
     Region          5..>51
                     /region_name="PHD_SF"
                     /note="PHD finger superfamily; cl22851"
                     /db_xref="CDD:473978"
     CDS             1..1828
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; PPP1R151; SGA72M; SLP2;
                     SLP2A"
                     /coded_by="XM_054369199.1:578..6064"
                     /db_xref="GeneID:54843"
                     /db_xref="HGNC:HGNC:15585"
                     /db_xref="MIM:612880"
ORIGIN      
        1 midlsfltee eqeaimkvlq rdaalkraee ervrhlpeki kddqqlknms gqwfyeakak
       61 rhrdkihgad iirasmrkkr pqiaaeqskd rengakeswv nnvnkdaflp pelagvveep
      121 eedaapasps ssvvnpassv idmsqentrk pnvspekqrk npfnssklpe ghssqqtkne
      181 qskngrtglf qtskedelse skekstvadt siqklekskq tlpglsngsq ikapipkark
      241 miykstdlnk ddnqsfprqr tdslkargap rgilkrnsss sstdsetlry nhnfepkski
      301 vspgltiher isekehsled nsspnslepl khvrfsavkd elpqspglih grevgefsvl
      361 esdrlkngme dagdteefqs dpkpsqyrkp slfhqstssp yvsksethqp mtsgsfping
      421 lhshsevlta rpqsmenspt inepkdksse ltrlesvlpr spadelshcv epepsqvpgg
      481 ssrdrqqgkp pplpalkakt ssrsgpyate ikkstddsif kvldwfnrss ysddnksflq
      541 hprgieskek tdsksqvavd lvtddttlre ngsktlspsk ielkpvrsds pfqaegdmlv
      601 sescqdnnvn ikskfmnlsq kgtpkegpgi lqpfesygtp sqgsknmdys qdskspgkgn
      661 gaspsnsnys ysvlkesdae nqvpcntnni gnlgeeepkf haheenrghs evnfdsstvv
      721 kepglkdnmn aerkskvgnt yilkaslepe nikstpgvan ngspwkkpev qfqqeagevp
      781 knqvqrekyk rvsdrisfwe gekagakith ekptsscsqe qpsakayqpv kksqgvssmd
      841 slstdqseyn qaipkrvvld eddqasqlsn syssnksket kpqiagpsry ylsaeqsdkv
      901 slfqnkknep ikrsqvadsl psrrnitlpa lqppsnvgse rhaplekdrp lvresnanfk
      961 vmslkermde pnaeqvynps qfenlrkfwd leansnskdn dknitttsqk nsapfnrqkh
     1021 kefsdiklsg kntheaevll spkkvmaree meklnskgil qvlpdeitfp lsplrkytyq
     1081 lpgnessken vekntegivt pvfkeekdys eqeiqesiik tnvlskdckd tfndslqkll
     1141 setstpaiqp sggkvhgkqv lepsvsenrt wpqktdfgdt eeevkgpeki inehvdktvv
     1201 hpkvkrnslt asldkllkea tgtspsplqa klapvitgtn skleegrffg kgieqshnts
     1261 adkreilapf pvrdetfgnt allkkaesge cqlstqnliq vaaedshpld ptsqlsrkgs
     1321 fgdvasppqd mlfpqgahlv pqarvhpsqm eisetvekvi lpprpvlndv saalqklcge
     1381 vwlsypagre vgpgevnpef peavqpvcsp lnppgvispw atmdtivpdr kdfyssnvvp
     1441 dkthevgsyl aaqmspsdqt lssfasivaq ygkglpqeve eivretivqp kseflefsag
     1501 lekllkeete tfpskyesdt gnlspsklig steeprrats echpeelket vekaeaplit
     1561 esafdagfek llkeiteapp yqpqvsvree thekessqse qtrflgtvph fyraasqtse
     1621 mkdksngles qvnqcdkmlg gdalvtdllv dfcgsrsgve iprtpqlyva heigtiktvt
     1681 ppedrdsesg vaggqgtlqe pgfgeaseai svsrnrqpip llmnkenstk tskveltlas
     1741 pymkqekeee kegfsesdfs dgntssnaes wrnpssseee pspvlktler saarkmpsks
     1801 ledissdssn qakvdnqpee lvrsaede
//
LOCUS       XP_054225175             908 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-like protein 2 isoform X9 [Homo sapiens].
ACCESSION   XP_054225175
VERSION     XP_054225175.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369200.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..908
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..908
                     /product="synaptotagmin-like protein 2 isoform X9"
                     /calculated_mol_wt=101901
     Region          5..>51
                     /region_name="PHD_SF"
                     /note="PHD finger superfamily; cl22851"
                     /db_xref="CDD:473978"
     Region          603..730
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     Region          743..899
                     /region_name="C2B_SLP_1-2-3-4"
                     /note="C2 domain second repeat present in
                     Synaptotagmin-like proteins 1-4; cd04020"
                     /db_xref="CDD:175987"
     CDS             1..908
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; PPP1R151; SGA72M; SLP2;
                     SLP2A"
                     /coded_by="XM_054369200.1:578..3304"
                     /db_xref="GeneID:54843"
                     /db_xref="HGNC:HGNC:15585"
                     /db_xref="MIM:612880"
ORIGIN      
        1 midlsfltee eqeaimkvlq rdaalkraee ervrhlpeki kddqqlknms gqwfyeakak
       61 rhrdkihgad iirasmrkkr pqiaelagvv eepeedaapa spsssvvnpa ssvidmsqen
      121 trkpnvspek qrknpfnssk lpeghssqqt kneqskngrt glfqtskede lseskekstv
      181 adtsiqklek skqtlpglsn gsqikapipk arkmiykstd lnkddnqsfp rqrtdslkar
      241 gaprgilkrn ssssstdset lrynhnfepk skivspglti herisekehs lednsspnsl
      301 eplkhvrfsa vkdelpqspg lihgrevgef svlesdrlkn gmedagdtee fqsdpkpsqy
      361 rkpslfhqst sspyvskset hqpmtsgsfp inglhshsev ltarpqsmen sptinepkdk
      421 sseltrlesv lprspadels hcvepepsqv pggssrdrqq gseeepspvl ktlersaark
      481 mpsksledis sdssnqakvd nqpeelvrsa edvstvptqp dnpfshpdkl krmsksvpaf
      541 lqdesddret dtasessyql srhkkspssl tnlssssgmt slssvsgsvm svysgdfgnl
      601 evkgniqfai eyveslkelh vfvaqckdla aadvkkqrsd pyvkayllpd kgkmgkkktl
      661 vvkktlnpvy neilrykiek qilktqklnl siwhrdtfkr nsflgeveld letwdwdnkq
      721 nkqlrwyplk rktapvalea enrgemklal qyvpepvpgk klpttgevhi wvkecldlpl
      781 lrgshlnsfv kctilpdtsr ksrqktravg kttnpifnht mvydgfrped lmeacveltv
      841 wdhykltnqf lgglrigfgt gksygtevdw mdstseeval wekmvnspnt wieatlplrm
      901 lliakisk
//
LOCUS       XP_054225176             895 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-like protein 2 isoform X11 [Homo sapiens].
ACCESSION   XP_054225176
VERSION     XP_054225176.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369201.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..895
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..895
                     /product="synaptotagmin-like protein 2 isoform X11"
                     /calculated_mol_wt=100693
     Region          5..>51
                     /region_name="PHD_SF"
                     /note="PHD finger superfamily; cl22851"
                     /db_xref="CDD:473978"
     Region          590..717
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     Region          730..886
                     /region_name="C2B_SLP_1-2-3-4"
                     /note="C2 domain second repeat present in
                     Synaptotagmin-like proteins 1-4; cd04020"
                     /db_xref="CDD:175987"
     CDS             1..895
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; PPP1R151; SGA72M; SLP2;
                     SLP2A"
                     /coded_by="XM_054369201.1:578..3265"
                     /db_xref="GeneID:54843"
                     /db_xref="HGNC:HGNC:15585"
                     /db_xref="MIM:612880"
ORIGIN      
        1 midlsfltee eqeaimkvlq rdaalkraee ervrhlpeki kddqqlknms gqwfyeakak
       61 rhrdkihgad iirasmrkkr pqiaaeqskd rengakeswv nnvnkdaflp pelagvveep
      121 eedaapasps ssvvnpassv idmsqentrk pnvspekqrk npfnssklpe ghssqqtkne
      181 qskngrtglf qtskedelse skekstvadt siqklekskq tlpglsngsq ikapipkark
      241 miykstdlnk ddnqsfprqr tdslkargap rgilkrnsss sstdsetlry nhnfepkski
      301 vspgltiher isekehsled nsspnslepl khvrfsavkd elpqspglih grevgefsvl
      361 esdrlkngme dagdteefqs dpkpsqyrkp slfhqstssp yvsksethqp mtsgsfping
      421 lhshsevlta rpqsmenspt inepkdksse ltrlesvlpr spadelshcv epepsqvpgg
      481 ssrdrqqgse eepspvlktl ersaarkmps ksledissds snqakvdnqp eelvrsaedv
      541 stvptqpdnp fshpdklkrm sksvpaflqd evsgsvmsvy sgdfgnlevk gniqfaieyv
      601 eslkelhvfv aqckdlaaad vkkqrsdpyv kayllpdkgk mgkkktlvvk ktlnpvynei
      661 lrykiekqil ktqklnlsiw hrdtfkrnsf lgeveldlet wdwdnkqnkq lrwyplkrkt
      721 apvaleaenr gemklalqyv pepvpgkklp ttgevhiwvk ecldlpllrg shlnsfvkct
      781 ilpdtsrksr qktravgktt npifnhtmvy dgfrpedlme acveltvwdh ykltnqflgg
      841 lrigfgtgks ygtevdwmds tseevalwek mvnspntwie atlplrmlli akisk
//
LOCUS       XP_054225177             894 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-like protein 2 isoform X12 [Homo sapiens].
ACCESSION   XP_054225177
VERSION     XP_054225177.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369202.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..894
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..894
                     /product="synaptotagmin-like protein 2 isoform X12"
                     /calculated_mol_wt=100565
     Region          5..>51
                     /region_name="PHD_SF"
                     /note="PHD finger superfamily; cl22851"
                     /db_xref="CDD:473978"
     Region          589..716
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     Region          729..885
                     /region_name="C2B_SLP_1-2-3-4"
                     /note="C2 domain second repeat present in
                     Synaptotagmin-like proteins 1-4; cd04020"
                     /db_xref="CDD:175987"
     CDS             1..894
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; PPP1R151; SGA72M; SLP2;
                     SLP2A"
                     /coded_by="XM_054369202.1:578..3262"
                     /db_xref="GeneID:54843"
                     /db_xref="HGNC:HGNC:15585"
                     /db_xref="MIM:612880"
ORIGIN      
        1 midlsfltee eqeaimkvlq rdaalkraee ervrhlpeki kddqqlknms gqwfyeakak
       61 rhrdkihgad iirasmrkkr pqiaaeqskd rengakeswv nnvnkdaflp pelagvveep
      121 eedaapasps ssvvnpassv idmsqentrk pnvspekrkn pfnssklpeg hssqqtkneq
      181 skngrtglfq tskedelses kekstvadts iqklekskqt lpglsngsqi kapipkarkm
      241 iykstdlnkd dnqsfprqrt dslkargapr gilkrnssss stdsetlryn hnfepkskiv
      301 spgltiheri sekehsledn sspnsleplk hvrfsavkde lpqspglihg revgefsvle
      361 sdrlkngmed agdteefqsd pkpsqyrkps lfhqstsspy vsksethqpm tsgsfpingl
      421 hshsevltar pqsmenspti nepkdkssel trlesvlprs padelshcve pepsqvpggs
      481 srdrqqgsee epspvlktle rsaarkmpsk sledissdss nqakvdnqpe elvrsaedvs
      541 tvptqpdnpf shpdklkrms ksvpaflqde vsgsvmsvys gdfgnlevkg niqfaieyve
      601 slkelhvfva qckdlaaadv kkqrsdpyvk ayllpdkgkm gkkktlvvkk tlnpvyneil
      661 rykiekqilk tqklnlsiwh rdtfkrnsfl geveldletw dwdnkqnkql rwyplkrkta
      721 pvaleaenrg emklalqyvp epvpgkklpt tgevhiwvke cldlpllrgs hlnsfvkcti
      781 lpdtsrksrq ktravgkttn pifnhtmvyd gfrpedlmea cveltvwdhy kltnqflggl
      841 rigfgtgksy gtevdwmdst seevalwekm vnspntwiea tlplrmllia kisk
//
LOCUS       XP_054225178             894 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-like protein 2 isoform X13 [Homo sapiens].
ACCESSION   XP_054225178
VERSION     XP_054225178.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369203.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..894
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..894
                     /product="synaptotagmin-like protein 2 isoform X13"
                     /calculated_mol_wt=99576
     Region          5..>51
                     /region_name="PHD_SF"
                     /note="PHD finger superfamily; cl22851"
                     /db_xref="CDD:473978"
     Region          646..>718
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     Region          729..885
                     /region_name="C2B_SLP_1-2-3-4"
                     /note="C2 domain second repeat present in
                     Synaptotagmin-like proteins 1-4; cd04020"
                     /db_xref="CDD:175987"
     CDS             1..894
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; PPP1R151; SGA72M; SLP2;
                     SLP2A"
                     /coded_by="XM_054369203.1:578..3262"
                     /db_xref="GeneID:54843"
                     /db_xref="HGNC:HGNC:15585"
                     /db_xref="MIM:612880"
ORIGIN      
        1 midlsfltee eqeaimkvlq rdaalkraee ervrhlpeki kddqqlknms gqwfyeakak
       61 rhrdkihgad iirasmrkkr pqiaaeqskd rengakeswv nnvnkdaflp pelagvveep
      121 eedaapasps ssvvnpassv idmsqentrk pnvspekqrk npfnssklpe ghssqqtkne
      181 qskngrtglf qtskedelse skekstvadt siqklekskq tlpglsngsq ikapipkark
      241 miykstdlnk ddnqsfprqr tdslkargap rgilkrnsss sstdsetlry nhnfepkski
      301 vspgltiher isekehsled nsspnslepl khvrfsavkd elpqspglih grevgefsvl
      361 esdrlkngme dagdteefqs dpkpsqyrkp slfhqstssp yvsksethqp mtsgsfping
      421 lhshsevlta rpqsmenspt inepkdksse ltrlesvlpr spadelshcv epepsqvpgg
      481 ssrdrqqgse eepspvlktl ersaarkmps ksledissds snqakvdnqp eelvrsaedd
      541 ekpdqkpvtn ecvpristvp tqpdnpfshp dklkrmsksv paflqdesdd retdtasess
      601 yqlsrhkksp ssltnlssss gmtslssvsg svmsvysgdf gnlevkgniq faieyveslk
      661 elhvfvaqck dlaaadvkkq rsdpyvkayl lpdkgkmgkk ktlvvkktln pvyneilrta
      721 pvaleaenrg emklalqyvp epvpgkklpt tgevhiwvke cldlpllrgs hlnsfvkcti
      781 lpdtsrksrq ktravgkttn pifnhtmvyd gfrpedlmea cveltvwdhy kltnqflggl
      841 rigfgtgksy gtevdwmdst seevalwekm vnspntwiea tlplrmllia kisk
//
LOCUS       XP_054225179             884 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-like protein 2 isoform X15 [Homo sapiens].
ACCESSION   XP_054225179
VERSION     XP_054225179.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369204.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..884
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..884
                     /product="synaptotagmin-like protein 2 isoform X15"
                     /calculated_mol_wt=99518
     Region          5..>51
                     /region_name="PHD_SF"
                     /note="PHD finger superfamily; cl22851"
                     /db_xref="CDD:473978"
     Region          579..706
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     Region          719..875
                     /region_name="C2B_SLP_1-2-3-4"
                     /note="C2 domain second repeat present in
                     Synaptotagmin-like proteins 1-4; cd04020"
                     /db_xref="CDD:175987"
     CDS             1..884
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; PPP1R151; SGA72M; SLP2;
                     SLP2A"
                     /coded_by="XM_054369204.1:578..3232"
                     /db_xref="GeneID:54843"
                     /db_xref="HGNC:HGNC:15585"
                     /db_xref="MIM:612880"
ORIGIN      
        1 midlsfltee eqeaimkvlq rdaalkraee ervrhlpeki kddqqlknms gqwfyeakak
       61 rhrdkihgad iirasmrkkr pqiaelagvv eepeedaapa spsssvvnpa ssvidmsqen
      121 trkpnvspek qrknpfnssk lpeghssqqt kneqskngrt glfqtskede lseskekstv
      181 adtsiqklek skqtlpglsn gsqikapipk arkmiykstd lnkddnqsfp rqrtdslkar
      241 gaprgilkrn ssssstdset lrynhnfepk skivspglti herisekehs lednsspnsl
      301 eplkhvrfsa vkdelpqspg lihgrevgef svlesdrlkn gmedagdtee fqsdpkpsqy
      361 rkpslfhqst sspyvskset hqpmtsgsfp inglhshsev ltarpqsmen sptinepkdk
      421 sseltrlesv lprspadels hcvepepsqv pggssrdrqq gseeepspvl ktlersaark
      481 mpsksledis sdssnqakvd nqpeelvrsa eddekpdqkp vtnecvpris tvptqpdnpf
      541 shpdklkrms ksvpaflqde vsgsvmsvys gdfgnlevkg niqfaieyve slkelhvfva
      601 qckdlaaadv kkqrsdpyvk ayllpdkgkm gkkktlvvkk tlnpvyneil rykiekqilk
      661 tqklnlsiwh rdtfkrnsfl geveldletw dwdnkqnkql rwyplkrkta pvaleaenrg
      721 emklalqyvp epvpgkklpt tgevhiwvke cldlpllrgs hlnsfvkcti lpdtsrksrq
      781 ktravgkttn pifnhtmvyd gfrpedlmea cveltvwdhy kltnqflggl rigfgtgksy
      841 gtevdwmdst seevalwekm vnspntwiea tlplrmllia kisk
//
LOCUS       XP_054225180             883 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-like protein 2 isoform X16 [Homo sapiens].
ACCESSION   XP_054225180
VERSION     XP_054225180.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369205.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..883
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..883
                     /product="synaptotagmin-like protein 2 isoform X16"
                     /calculated_mol_wt=99390
     Region          5..>51
                     /region_name="PHD_SF"
                     /note="PHD finger superfamily; cl22851"
                     /db_xref="CDD:473978"
     Region          578..705
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     Region          718..874
                     /region_name="C2B_SLP_1-2-3-4"
                     /note="C2 domain second repeat present in
                     Synaptotagmin-like proteins 1-4; cd04020"
                     /db_xref="CDD:175987"
     CDS             1..883
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; PPP1R151; SGA72M; SLP2;
                     SLP2A"
                     /coded_by="XM_054369205.1:578..3229"
                     /db_xref="GeneID:54843"
                     /db_xref="HGNC:HGNC:15585"
                     /db_xref="MIM:612880"
ORIGIN      
        1 midlsfltee eqeaimkvlq rdaalkraee ervrhlpeki kddqqlknms gqwfyeakak
       61 rhrdkihgad iirasmrkkr pqiaelagvv eepeedaapa spsssvvnpa ssvidmsqen
      121 trkpnvspek rknpfnsskl peghssqqtk neqskngrtg lfqtskedel seskekstva
      181 dtsiqkleks kqtlpglsng sqikapipka rkmiykstdl nkddnqsfpr qrtdslkarg
      241 aprgilkrns sssstdsetl rynhnfepks kivspgltih erisekehsl ednsspnsle
      301 plkhvrfsav kdelpqspgl ihgrevgefs vlesdrlkng medagdteef qsdpkpsqyr
      361 kpslfhqsts spyvskseth qpmtsgsfpi nglhshsevl tarpqsmens ptinepkdks
      421 seltrlesvl prspadelsh cvepepsqvp ggssrdrqqg seeepspvlk tlersaarkm
      481 pskslediss dssnqakvdn qpeelvrsae ddekpdqkpv tnecvprist vptqpdnpfs
      541 hpdklkrmsk svpaflqdev sgsvmsvysg dfgnlevkgn iqfaieyves lkelhvfvaq
      601 ckdlaaadvk kqrsdpyvka yllpdkgkmg kkktlvvkkt lnpvyneilr ykiekqilkt
      661 qklnlsiwhr dtfkrnsflg eveldletwd wdnkqnkqlr wyplkrktap valeaenrge
      721 mklalqyvpe pvpgkklptt gevhiwvkec ldlpllrgsh lnsfvkctil pdtsrksrqk
      781 travgkttnp ifnhtmvydg frpedlmeac veltvwdhyk ltnqflgglr igfgtgksyg
      841 tevdwmdsts eevalwekmv nspntwieat lplrmlliak isk
//
LOCUS       XP_054225181             878 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-like protein 2 isoform X17 [Homo sapiens].
ACCESSION   XP_054225181
VERSION     XP_054225181.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369206.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..878
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..878
                     /product="synaptotagmin-like protein 2 isoform X17"
                     /calculated_mol_wt=97725
     Region          5..>51
                     /region_name="PHD_SF"
                     /note="PHD finger superfamily; cl22851"
                     /db_xref="CDD:473978"
     Region          630..>702
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     Region          713..869
                     /region_name="C2B_SLP_1-2-3-4"
                     /note="C2 domain second repeat present in
                     Synaptotagmin-like proteins 1-4; cd04020"
                     /db_xref="CDD:175987"
     CDS             1..878
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; PPP1R151; SGA72M; SLP2;
                     SLP2A"
                     /coded_by="XM_054369206.1:578..3214"
                     /db_xref="GeneID:54843"
                     /db_xref="HGNC:HGNC:15585"
                     /db_xref="MIM:612880"
ORIGIN      
        1 midlsfltee eqeaimkvlq rdaalkraee ervrhlpeki kddqqlknms gqwfyeakak
       61 rhrdkihgad iirasmrkkr pqiaaeqskd rengakeswv nnvnkdaflp pelagvveep
      121 eedaapasps ssvvnpassv idmsqentrk pnvspekqrk npfnssklpe ghssqqtkne
      181 qskngrtglf qtskedelse skekstvadt siqklekskq tlpglsngsq ikapipkark
      241 miykstdlnk ddnqsfprqr tdslkargap rgilkrnsss sstdsetlry nhnfepkski
      301 vspgltiher isekehsled nsspnslepl khvrfsavkd elpqspglih grevgefsvl
      361 esdrlkngme dagdteefqs dpkpsqyrkp slfhqstssp yvsksethqp mtsgsfping
      421 lhshsevlta rpqsmenspt inepkdksse ltrlesvlpr spadelshcv epepsqvpgg
      481 ssrdrqqgse eepspvlktl ersaarkmps ksledissds snqakvdnqp eelvrsaedv
      541 stvptqpdnp fshpdklkrm sksvpaflqd esddretdta sessyqlsrh kkspssltnl
      601 ssssgmtsls svsgsvmsvy sgdfgnlevk gniqfaieyv eslkelhvfv aqckdlaaad
      661 vkkqrsdpyv kayllpdkgk mgkkktlvvk ktlnpvynei lrtapvalea enrgemklal
      721 qyvpepvpgk klpttgevhi wvkecldlpl lrgshlnsfv kctilpdtsr ksrqktravg
      781 kttnpifnht mvydgfrped lmeacveltv wdhykltnqf lgglrigfgt gksygtevdw
      841 mdstseeval wekmvnspnt wieatlplrm lliakisk
//
LOCUS       XP_054225182             877 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-like protein 2 isoform X18 [Homo sapiens].
ACCESSION   XP_054225182
VERSION     XP_054225182.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369207.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..877
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..877
                     /product="synaptotagmin-like protein 2 isoform X18"
                     /calculated_mol_wt=97597
     Region          5..>51
                     /region_name="PHD_SF"
                     /note="PHD finger superfamily; cl22851"
                     /db_xref="CDD:473978"
     Region          629..>701
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     Region          712..868
                     /region_name="C2B_SLP_1-2-3-4"
                     /note="C2 domain second repeat present in
                     Synaptotagmin-like proteins 1-4; cd04020"
                     /db_xref="CDD:175987"
     CDS             1..877
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; PPP1R151; SGA72M; SLP2;
                     SLP2A"
                     /coded_by="XM_054369207.1:578..3211"
                     /db_xref="GeneID:54843"
                     /db_xref="HGNC:HGNC:15585"
                     /db_xref="MIM:612880"
ORIGIN      
        1 midlsfltee eqeaimkvlq rdaalkraee ervrhlpeki kddqqlknms gqwfyeakak
       61 rhrdkihgad iirasmrkkr pqiaaeqskd rengakeswv nnvnkdaflp pelagvveep
      121 eedaapasps ssvvnpassv idmsqentrk pnvspekrkn pfnssklpeg hssqqtkneq
      181 skngrtglfq tskedelses kekstvadts iqklekskqt lpglsngsqi kapipkarkm
      241 iykstdlnkd dnqsfprqrt dslkargapr gilkrnssss stdsetlryn hnfepkskiv
      301 spgltiheri sekehsledn sspnsleplk hvrfsavkde lpqspglihg revgefsvle
      361 sdrlkngmed agdteefqsd pkpsqyrkps lfhqstsspy vsksethqpm tsgsfpingl
      421 hshsevltar pqsmenspti nepkdkssel trlesvlprs padelshcve pepsqvpggs
      481 srdrqqgsee epspvlktle rsaarkmpsk sledissdss nqakvdnqpe elvrsaedvs
      541 tvptqpdnpf shpdklkrms ksvpaflqde sddretdtas essyqlsrhk kspssltnls
      601 sssgmtslss vsgsvmsvys gdfgnlevkg niqfaieyve slkelhvfva qckdlaaadv
      661 kkqrsdpyvk ayllpdkgkm gkkktlvvkk tlnpvyneil rtapvaleae nrgemklalq
      721 yvpepvpgkk lpttgevhiw vkecldlpll rgshlnsfvk ctilpdtsrk srqktravgk
      781 ttnpifnhtm vydgfrpedl meacveltvw dhykltnqfl gglrigfgtg ksygtevdwm
      841 dstseevalw ekmvnspntw ieatlplrml liakisk
//
LOCUS       XP_054225183             868 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-like protein 2 isoform X19 [Homo sapiens].
ACCESSION   XP_054225183
VERSION     XP_054225183.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369208.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..868
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..868
                     /product="synaptotagmin-like protein 2 isoform X19"
                     /calculated_mol_wt=97667
     Region          5..>51
                     /region_name="PHD_SF"
                     /note="PHD finger superfamily; cl22851"
                     /db_xref="CDD:473978"
     Region          563..690
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     Region          703..859
                     /region_name="C2B_SLP_1-2-3-4"
                     /note="C2 domain second repeat present in
                     Synaptotagmin-like proteins 1-4; cd04020"
                     /db_xref="CDD:175987"
     CDS             1..868
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; PPP1R151; SGA72M; SLP2;
                     SLP2A"
                     /coded_by="XM_054369208.1:578..3184"
                     /db_xref="GeneID:54843"
                     /db_xref="HGNC:HGNC:15585"
                     /db_xref="MIM:612880"
ORIGIN      
        1 midlsfltee eqeaimkvlq rdaalkraee ervrhlpeki kddqqlknms gqwfyeakak
       61 rhrdkihgad iirasmrkkr pqiaelagvv eepeedaapa spsssvvnpa ssvidmsqen
      121 trkpnvspek qrknpfnssk lpeghssqqt kneqskngrt glfqtskede lseskekstv
      181 adtsiqklek skqtlpglsn gsqikapipk arkmiykstd lnkddnqsfp rqrtdslkar
      241 gaprgilkrn ssssstdset lrynhnfepk skivspglti herisekehs lednsspnsl
      301 eplkhvrfsa vkdelpqspg lihgrevgef svlesdrlkn gmedagdtee fqsdpkpsqy
      361 rkpslfhqst sspyvskset hqpmtsgsfp inglhshsev ltarpqsmen sptinepkdk
      421 sseltrlesv lprspadels hcvepepsqv pggssrdrqq gseeepspvl ktlersaark
      481 mpsksledis sdssnqakvd nqpeelvrsa edvstvptqp dnpfshpdkl krmsksvpaf
      541 lqdevsgsvm svysgdfgnl evkgniqfai eyveslkelh vfvaqckdla aadvkkqrsd
      601 pyvkayllpd kgkmgkkktl vvkktlnpvy neilrykiek qilktqklnl siwhrdtfkr
      661 nsflgeveld letwdwdnkq nkqlrwyplk rktapvalea enrgemklal qyvpepvpgk
      721 klpttgevhi wvkecldlpl lrgshlnsfv kctilpdtsr ksrqktravg kttnpifnht
      781 mvydgfrped lmeacveltv wdhykltnqf lgglrigfgt gksygtevdw mdstseeval
      841 wekmvnspnt wieatlplrm lliakisk
//
LOCUS       XP_054225184             854 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-like protein 2 isoform X20 [Homo sapiens].
ACCESSION   XP_054225184
VERSION     XP_054225184.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369209.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..854
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..854
                     /product="synaptotagmin-like protein 2 isoform X20"
                     /calculated_mol_wt=95342
     Region          5..>51
                     /region_name="PHD_SF"
                     /note="PHD finger superfamily; cl22851"
                     /db_xref="CDD:473978"
     Region          606..>678
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     Region          689..845
                     /region_name="C2B_SLP_1-2-3-4"
                     /note="C2 domain second repeat present in
                     Synaptotagmin-like proteins 1-4; cd04020"
                     /db_xref="CDD:175987"
     CDS             1..854
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; PPP1R151; SGA72M; SLP2;
                     SLP2A"
                     /coded_by="XM_054369209.1:578..3142"
                     /db_xref="GeneID:54843"
                     /db_xref="HGNC:HGNC:15585"
                     /db_xref="MIM:612880"
ORIGIN      
        1 midlsfltee eqeaimkvlq rdaalkraee ervrhlpeki kddqqlknms gqwfyeakak
       61 rhrdkihgad iirasmrkkr pqiaaeqskd rengakeswv nnvnkdaflp pelagvveep
      121 eedaapasps ssvvnpassv idmsqentrk pnvspekqrk npfnssklpe ghssqqtkne
      181 qskngrtglf qtskedelse skekstvadt siqklekskq tlpglsngsq ikapipkark
      241 miykstdlnk ddnqsfprqr tdslkargap rgilkrnsss sstdsetlry nhnfepkski
      301 vspgltiher isekehsled nsspnslepl khvrfsavkd elpqspglih grevgefsvl
      361 esdrlkngme dagdteefqs dpkpsqyrkp slfhqstssp yvsksethqp mtsgsfping
      421 lhshsevlta rpqsmenspt inepkdksse ltrlesvlpr spadelshcv epepsqvpgg
      481 ssrdrqqgse eepspvlktl ersaarkmps ksledissds snqakvdnqp eelvrsaedd
      541 ekpdqkpvtn ecvpristvp tqpdnpfshp dklkrmsksv paflqdevsg svmsvysgdf
      601 gnlevkgniq faieyveslk elhvfvaqck dlaaadvkkq rsdpyvkayl lpdkgkmgkk
      661 ktlvvkktln pvyneilrta pvaleaenrg emklalqyvp epvpgkklpt tgevhiwvke
      721 cldlpllrgs hlnsfvkcti lpdtsrksrq ktravgkttn pifnhtmvyd gfrpedlmea
      781 cveltvwdhy kltnqflggl rigfgtgksy gtevdwmdst seevalwekm vnspntwiea
      841 tlplrmllia kisk
//
LOCUS       XP_054225185             851 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-like protein 2 isoform X21 [Homo sapiens].
ACCESSION   XP_054225185
VERSION     XP_054225185.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369210.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..851
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..851
                     /product="synaptotagmin-like protein 2 isoform X21"
                     /calculated_mol_wt=94699
     Region          5..>51
                     /region_name="PHD_SF"
                     /note="PHD finger superfamily; cl22851"
                     /db_xref="CDD:473978"
     Region          603..>675
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     Region          686..842
                     /region_name="C2B_SLP_1-2-3-4"
                     /note="C2 domain second repeat present in
                     Synaptotagmin-like proteins 1-4; cd04020"
                     /db_xref="CDD:175987"
     CDS             1..851
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; PPP1R151; SGA72M; SLP2;
                     SLP2A"
                     /coded_by="XM_054369210.1:578..3133"
                     /db_xref="GeneID:54843"
                     /db_xref="HGNC:HGNC:15585"
                     /db_xref="MIM:612880"
ORIGIN      
        1 midlsfltee eqeaimkvlq rdaalkraee ervrhlpeki kddqqlknms gqwfyeakak
       61 rhrdkihgad iirasmrkkr pqiaelagvv eepeedaapa spsssvvnpa ssvidmsqen
      121 trkpnvspek qrknpfnssk lpeghssqqt kneqskngrt glfqtskede lseskekstv
      181 adtsiqklek skqtlpglsn gsqikapipk arkmiykstd lnkddnqsfp rqrtdslkar
      241 gaprgilkrn ssssstdset lrynhnfepk skivspglti herisekehs lednsspnsl
      301 eplkhvrfsa vkdelpqspg lihgrevgef svlesdrlkn gmedagdtee fqsdpkpsqy
      361 rkpslfhqst sspyvskset hqpmtsgsfp inglhshsev ltarpqsmen sptinepkdk
      421 sseltrlesv lprspadels hcvepepsqv pggssrdrqq gseeepspvl ktlersaark
      481 mpsksledis sdssnqakvd nqpeelvrsa edvstvptqp dnpfshpdkl krmsksvpaf
      541 lqdesddret dtasessyql srhkkspssl tnlssssgmt slssvsgsvm svysgdfgnl
      601 evkgniqfai eyveslkelh vfvaqckdla aadvkkqrsd pyvkayllpd kgkmgkkktl
      661 vvkktlnpvy neilrtapva leaenrgemk lalqyvpepv pgkklpttge vhiwvkecld
      721 lpllrgshln sfvkctilpd tsrksrqktr avgkttnpif nhtmvydgfr pedlmeacve
      781 ltvwdhyklt nqflgglrig fgtgksygte vdwmdstsee valwekmvns pntwieatlp
      841 lrmlliakis k
//
LOCUS       XP_054225186             850 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-like protein 2 isoform X22 [Homo sapiens].
ACCESSION   XP_054225186
VERSION     XP_054225186.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369211.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..850
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..850
                     /product="synaptotagmin-like protein 2 isoform X22"
                     /calculated_mol_wt=94571
     Region          5..>51
                     /region_name="PHD_SF"
                     /note="PHD finger superfamily; cl22851"
                     /db_xref="CDD:473978"
     Region          602..>674
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     Region          685..841
                     /region_name="C2B_SLP_1-2-3-4"
                     /note="C2 domain second repeat present in
                     Synaptotagmin-like proteins 1-4; cd04020"
                     /db_xref="CDD:175987"
     CDS             1..850
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; PPP1R151; SGA72M; SLP2;
                     SLP2A"
                     /coded_by="XM_054369211.1:578..3130"
                     /db_xref="GeneID:54843"
                     /db_xref="HGNC:HGNC:15585"
                     /db_xref="MIM:612880"
ORIGIN      
        1 midlsfltee eqeaimkvlq rdaalkraee ervrhlpeki kddqqlknms gqwfyeakak
       61 rhrdkihgad iirasmrkkr pqiaelagvv eepeedaapa spsssvvnpa ssvidmsqen
      121 trkpnvspek rknpfnsskl peghssqqtk neqskngrtg lfqtskedel seskekstva
      181 dtsiqkleks kqtlpglsng sqikapipka rkmiykstdl nkddnqsfpr qrtdslkarg
      241 aprgilkrns sssstdsetl rynhnfepks kivspgltih erisekehsl ednsspnsle
      301 plkhvrfsav kdelpqspgl ihgrevgefs vlesdrlkng medagdteef qsdpkpsqyr
      361 kpslfhqsts spyvskseth qpmtsgsfpi nglhshsevl tarpqsmens ptinepkdks
      421 seltrlesvl prspadelsh cvepepsqvp ggssrdrqqg seeepspvlk tlersaarkm
      481 pskslediss dssnqakvdn qpeelvrsae dvstvptqpd npfshpdklk rmsksvpafl
      541 qdesddretd tasessyqls rhkkspsslt nlssssgmts lssvsgsvms vysgdfgnle
      601 vkgniqfaie yveslkelhv fvaqckdlaa advkkqrsdp yvkayllpdk gkmgkkktlv
      661 vkktlnpvyn eilrtapval eaenrgemkl alqyvpepvp gkklpttgev hiwvkecldl
      721 pllrgshlns fvkctilpdt srksrqktra vgkttnpifn htmvydgfrp edlmeacvel
      781 tvwdhykltn qflgglrigf gtgksygtev dwmdstseev alwekmvnsp ntwieatlpl
      841 rmlliakisk
//
LOCUS       XP_054225187             827 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-like protein 2 isoform X23 [Homo sapiens].
ACCESSION   XP_054225187
VERSION     XP_054225187.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369212.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..827
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..827
                     /product="synaptotagmin-like protein 2 isoform X23"
                     /calculated_mol_wt=92315
     Region          5..>51
                     /region_name="PHD_SF"
                     /note="PHD finger superfamily; cl22851"
                     /db_xref="CDD:473978"
     Region          579..>651
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     Region          662..818
                     /region_name="C2B_SLP_1-2-3-4"
                     /note="C2 domain second repeat present in
                     Synaptotagmin-like proteins 1-4; cd04020"
                     /db_xref="CDD:175987"
     CDS             1..827
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; PPP1R151; SGA72M; SLP2;
                     SLP2A"
                     /coded_by="XM_054369212.1:578..3061"
                     /db_xref="GeneID:54843"
                     /db_xref="HGNC:HGNC:15585"
                     /db_xref="MIM:612880"
ORIGIN      
        1 midlsfltee eqeaimkvlq rdaalkraee ervrhlpeki kddqqlknms gqwfyeakak
       61 rhrdkihgad iirasmrkkr pqiaelagvv eepeedaapa spsssvvnpa ssvidmsqen
      121 trkpnvspek qrknpfnssk lpeghssqqt kneqskngrt glfqtskede lseskekstv
      181 adtsiqklek skqtlpglsn gsqikapipk arkmiykstd lnkddnqsfp rqrtdslkar
      241 gaprgilkrn ssssstdset lrynhnfepk skivspglti herisekehs lednsspnsl
      301 eplkhvrfsa vkdelpqspg lihgrevgef svlesdrlkn gmedagdtee fqsdpkpsqy
      361 rkpslfhqst sspyvskset hqpmtsgsfp inglhshsev ltarpqsmen sptinepkdk
      421 sseltrlesv lprspadels hcvepepsqv pggssrdrqq gseeepspvl ktlersaark
      481 mpsksledis sdssnqakvd nqpeelvrsa eddekpdqkp vtnecvpris tvptqpdnpf
      541 shpdklkrms ksvpaflqde vsgsvmsvys gdfgnlevkg niqfaieyve slkelhvfva
      601 qckdlaaadv kkqrsdpyvk ayllpdkgkm gkkktlvvkk tlnpvyneil rtapvaleae
      661 nrgemklalq yvpepvpgkk lpttgevhiw vkecldlpll rgshlnsfvk ctilpdtsrk
      721 srqktravgk ttnpifnhtm vydgfrpedl meacveltvw dhykltnqfl gglrigfgtg
      781 ksygtevdwm dstseevalw ekmvnspntw ieatlplrml liakisk
//
LOCUS       XP_054225188             445 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-like protein 2 isoform X24 [Homo sapiens].
ACCESSION   XP_054225188
VERSION     XP_054225188.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369213.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..445
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..445
                     /product="synaptotagmin-like protein 2 isoform X24"
                     /calculated_mol_wt=50152
     Region          140..267
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     Region          280..436
                     /region_name="C2B_SLP_1-2-3-4"
                     /note="C2 domain second repeat present in
                     Synaptotagmin-like proteins 1-4; cd04020"
                     /db_xref="CDD:175987"
     CDS             1..445
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; PPP1R151; SGA72M; SLP2;
                     SLP2A"
                     /coded_by="XM_054369213.1:56..1393"
                     /db_xref="GeneID:54843"
                     /db_xref="HGNC:HGNC:15585"
                     /db_xref="MIM:612880"
ORIGIN      
        1 mgapamalaq ganlknqakv dnqpeelvrs aeddekpdqk pvtnecvpri stvptqpdnp
       61 fshpdklkrm sksvpaflqd esddretdta sessyqlsrh kkspssltnl ssssgmtsls
      121 svsgsvmsvy sgdfgnlevk gniqfaieyv eslkelhvfv aqckdlaaad vkkqrsdpyv
      181 kayllpdkgk mgkkktlvvk ktlnpvynei lrykiekqil ktqklnlsiw hrdtfkrnsf
      241 lgeveldlet wdwdnkqnkq lrwyplkrkt apvaleaenr gemklalqyv pepvpgkklp
      301 ttgevhiwvk ecldlpllrg shlnsfvkct ilpdtsrksr qktravgktt npifnhtmvy
      361 dgfrpedlme acveltvwdh ykltnqflgg lrigfgtgks ygtevdwmds tseevalwek
      421 mvnspntwie atlplrmlli akisk
//
LOCUS       XP_054225189             365 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-like protein 2 isoform X25 [Homo sapiens].
ACCESSION   XP_054225189
VERSION     XP_054225189.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369214.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 7% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..365
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..365
                     /product="synaptotagmin-like protein 2 isoform X25"
                     /calculated_mol_wt=41403
     Region          60..187
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     Region          200..356
                     /region_name="C2B_SLP_1-2-3-4"
                     /note="C2 domain second repeat present in
                     Synaptotagmin-like proteins 1-4; cd04020"
                     /db_xref="CDD:175987"
     CDS             1..365
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; PPP1R151; SGA72M; SLP2;
                     SLP2A"
                     /coded_by="XM_054369214.1:153..1250"
                     /db_xref="GeneID:54843"
                     /db_xref="HGNC:HGNC:15585"
                     /db_xref="MIM:612880"
ORIGIN      
        1 msddretdta sessyqlsrh kkspssltnl ssssgmtsls svsgsvmsvy sgdfgnlevk
       61 gniqfaieyv eslkelhvfv aqckdlaaad vkkqrsdpyv kayllpdkgk mgkkktlvvk
      121 ktlnpvynei lrykiekqil ktqklnlsiw hrdtfkrnsf lgeveldlet wdwdnkqnkq
      181 lrwyplkrkt apvaleaenr gemklalqyv pepvpgkklp ttgevhiwvk ecldlpllrg
      241 shlnsfvkct ilpdtsrksr qktravgktt npifnhtmvy dgfrpedlme acveltvwdh
      301 ykltnqflgg lrigfgtgks ygtevdwmds tseevalwek mvnspntwie atlplrmlli
      361 akisk
//
LOCUS       XP_054225190             325 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-like protein 2 isoform X26 [Homo sapiens].
ACCESSION   XP_054225190
VERSION     XP_054225190.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369215.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..325
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..325
                     /product="synaptotagmin-like protein 2 isoform X26"
                     /calculated_mol_wt=37168
     Region          20..147
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     Region          160..316
                     /region_name="C2B_SLP_1-2-3-4"
                     /note="C2 domain second repeat present in
                     Synaptotagmin-like proteins 1-4; cd04020"
                     /db_xref="CDD:175987"
     CDS             1..325
                     /gene="SYTL2"
                     /gene_synonym="CHR11SYT; EXO4; PPP1R151; SGA72M; SLP2;
                     SLP2A"
                     /coded_by="XM_054369215.1:157..1134"
                     /db_xref="GeneID:54843"
                     /db_xref="HGNC:HGNC:15585"
                     /db_xref="MIM:612880"
ORIGIN      
        1 mvsgsvmsvy sgdfgnlevk gniqfaieyv eslkelhvfv aqckdlaaad vkkqrsdpyv
       61 kayllpdkgk mgkkktlvvk ktlnpvynei lrykiekqil ktqklnlsiw hrdtfkrnsf
      121 lgeveldlet wdwdnkqnkq lrwyplkrkt apvaleaenr gemklalqyv pepvpgkklp
      181 ttgevhiwvk ecldlpllrg shlnsfvkct ilpdtsrksr qktravgktt npifnhtmvy
      241 dgfrpedlme acveltvwdh ykltnqflgg lrigfgtgks ygtevdwmds tseevalwek
      301 mvnspntwie atlplrmlli akisk
//
LOCUS       XP_054225191             239 aa            linear   PRI 05-AUG-2025
DEFINITION  ankyrin repeat domain-containing protein 49 isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225191
VERSION     XP_054225191.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369216.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..239
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..239
                     /product="ankyrin repeat domain-containing protein 49
                     isoform X1"
                     /calculated_mol_wt=27159
     Region          <77..>218
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          78..105
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(79..80,83..85,87..88,92,96,105,107,109,113..114,
                     117..119,121..122,126,129,138,140,142,146..147,150..152,
                     154..155,159,162)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          107..138
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          140..170
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     CDS             1..239
                     /gene="ANKRD49"
                     /gene_synonym="FGIF; GBIF"
                     /coded_by="XM_054369216.1:231..950"
                     /db_xref="GeneID:54851"
                     /db_xref="HGNC:HGNC:25970"
                     /db_xref="MIM:619571"
ORIGIN      
        1 mekekgnddg ipdqensldf sehfnqlell ethghliptg tqslwvgnsd edeeqddkne
       61 ewyrlqekkm ekdpsrlllw aaeknrlttv rrllsekath vntrdedeyt plhraaysgh
      121 ldivqeliaq gadvhavtvd gwtplhsack wnntrvasfl lqhdadinaq tkglltplhl
      181 aagnrdskdt lelllmnryv kpglknnlee tafdiarrts iyhylfeive gctnsspqs
//
LOCUS       XP_054225192             471 aa            linear   PRI 05-AUG-2025
DEFINITION  protein phosphatase Slingshot homolog 3 isoform X1 [Homo sapiens].
ACCESSION   XP_054225192
VERSION     XP_054225192.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369217.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..471
                     /product="protein phosphatase Slingshot homolog 3 isoform
                     X1"
                     /calculated_mol_wt=52582
     Region          3..259
                     /region_name="SSH-N"
                     /note="N-terminal domain conserved in slingshot (SSH)
                     phosphatases; cd11652"
                     /db_xref="CDD:212166"
     Region          272..320
                     /region_name="DEK_C"
                     /note="DEK C terminal domain; pfam08766"
                     /db_xref="CDD:462592"
     Region          326..469
                     /region_name="DSP_slingshot_3"
                     /note="dual specificity phosphatase domain of slingshot
                     homolog 3; cd14571"
                     /db_xref="CDD:350419"
     CDS             1..471
                     /gene="SSH3"
                     /gene_synonym="SSH3L"
                     /coded_by="XM_054369217.1:97..1512"
                     /db_xref="GeneID:54961"
                     /db_xref="HGNC:HGNC:30581"
                     /db_xref="MIM:606780"
ORIGIN      
        1 malvtvsrsp pgsgastpvg pwdqavqrrs rlqrrqsfav lrgavlglqd ggdnddaaea
       61 sseptekaps eeelhgdqtd fgqgsqspqk qeeqrqhlhl mvqllrpqdd irlaaqleap
      121 rpprlryllv vstregegls qdetvllgvd fpdssspsct lglvlplwsd tqvyldgdgg
      181 fsvtsggqsr ifkpisiqtm watlqvlhqa ceaalgsglv pggsaltwas hyqerlnseq
      241 sclnewtama dleslrppsa epggsseqeq meqairaelw kvldvsdles vtskeirqal
      301 elrlglplqq yrdfidnqml llvaqrdras rifphlylgs ewnaanleel qrnrvthiln
      361 mareidnfyp erftyhnvrl wdeesaqllp hwkethrfie aaraqgthvl vhckmgvsrs
      421 aatvlayamk qyecsleqal rhvqelrpia rpnpgflrql qiyqgiltar t
//
LOCUS       XP_054225193            1037 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 132A isoform X1 [Homo sapiens].
ACCESSION   XP_054225193
VERSION     XP_054225193.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369218.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1037
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1037
                     /product="transmembrane protein 132A isoform X1"
                     /calculated_mol_wt=111121
     Region          61..181
                     /region_name="TMEM132D_N"
                     /note="Mature oligodendrocyte transmembrane protein,
                     TMEM132D, N-term; pfam15705"
                     /db_xref="CDD:464813"
     Region          421..764
                     /region_name="TMEM132"
                     /note="Transmembrane protein family 132; pfam16070"
                     /db_xref="CDD:465003"
     Region          <850..915
                     /region_name="TMEM132D_C"
                     /note="Mature oligodendrocyte transmembrane protein,
                     TMEM132D, C-term; pfam15706"
                     /db_xref="CDD:464814"
     CDS             1..1037
                     /gene="TMEM132A"
                     /gene_synonym="GBP; HSPA5BP1"
                     /coded_by="XM_054369218.1:2534..5647"
                     /db_xref="GeneID:54972"
                     /db_xref="HGNC:HGNC:31092"
                     /db_xref="MIM:617363"
ORIGIN      
        1 mvvrgegtft alfslpcpql lcpsmapgsa passgaviis psyassvdcg qapldpvylp
       61 aalelldape hfrvqqvghy ppansslssr setflllqpw praqpllras yppfatqqvv
      121 pprvtephqr pvpwdvravs veaavtpaep yarvlfhlkg qdwppgsgsl pcarlhathp
      181 agtahqacrf qpslgacvve lelpshwfsq asttraelay tlepaaegpg gcgsgeendp
      241 geqalpvggv elrpadppqy qevpldeavt lrvpdmpvrp gqlfsatlll rhnftasllt
      301 lrikvkkglh vtaarpaqpt lwtakldrfk gsrhhttlit chragltepd sssplelsef
      361 lwvdfvvens tgggvavtrp vtwqleypgq apeaekdkmv weilvserdi raliplakae
      421 elvntapltg vpqhvpvrlv tvdgggalve vtehvgcesa ntqvlqvsea cdavfvagke
      481 srgargvrvd fwwrrlrasl rltvwapllp lrieltdttl eqvrgwrvpg paegpaepaa
      541 easdeaerra rgchlqyqra gvrflapfaa hpldggrrlt hllgpdwlld vshlvaphar
      601 vldsrvasle ggrvvvgrep gvtsievrsp lsdsilgeqa lavtddkvsv lelrvqpvmg
      661 isltlsrgta hpgevtatcw aqsalpapkq evalslwlsf sdhtvapael ydrrdlglsv
      721 saeepgailp aeeqgaqlgv vvsgagaegl plhvalhppe pcrrgrhrvp lasgtawlgl
      781 ppastpapal psspawsppa teatmggkrq vagsvggntg vrgkferaee earkeetear
      841 eeeeeeeeem vpapqhvtel elgmyallgv fcvaififlv ngvvfvlryq rkeppdsatd
      901 ptspqphnwv wlgtdqeels rqldrqspgp pkgegscpce sggggeaptl apgppggtts
      961 ssstlarkea ggrrkrvefv tfvpappaqs peepvgapav qsilvageed irwvcedmgl
     1021 kdpeelrnym erirgss
//
LOCUS       XP_054225194            1036 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 132A isoform X2 [Homo sapiens].
ACCESSION   XP_054225194
VERSION     XP_054225194.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369219.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1036
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1036
                     /product="transmembrane protein 132A isoform X2"
                     /calculated_mol_wt=111034
     Region          61..181
                     /region_name="TMEM132D_N"
                     /note="Mature oligodendrocyte transmembrane protein,
                     TMEM132D, N-term; pfam15705"
                     /db_xref="CDD:464813"
     Region          420..763
                     /region_name="TMEM132"
                     /note="Transmembrane protein family 132; pfam16070"
                     /db_xref="CDD:465003"
     Region          <849..914
                     /region_name="TMEM132D_C"
                     /note="Mature oligodendrocyte transmembrane protein,
                     TMEM132D, C-term; pfam15706"
                     /db_xref="CDD:464814"
     CDS             1..1036
                     /gene="TMEM132A"
                     /gene_synonym="GBP; HSPA5BP1"
                     /coded_by="XM_054369219.1:2409..5519"
                     /db_xref="GeneID:54972"
                     /db_xref="HGNC:HGNC:31092"
                     /db_xref="MIM:617363"
ORIGIN      
        1 mvvrgegtft alfslpcpql lcpsmapgsa passgaviis psyassvdcg qapldpvylp
       61 aalelldape hfrvqqvghy ppansslssr setflllqpw praqpllras yppfatqqvv
      121 pprvtephqr pvpwdvravs veaavtpaep yarvlfhlkg qdwppgsgsl pcarlhathp
      181 agtahqacrf qpslgacvve lelpshwfsq asttraelay tlepaaegpg gcgsgeendp
      241 geqalpvggv elrpadppqy qevpldeavt lrvpdmpvrp gqlfsatlll rhnftasllt
      301 lrikvkkglh vtaarpaqpt lwtakldrfk gsrhhttlit chragltepd ssplelsefl
      361 wvdfvvenst gggvavtrpv twqleypgqa peaekdkmvw eilvserdir aliplakaee
      421 lvntapltgv pqhvpvrlvt vdgggalvev tehvgcesan tqvlqvseac davfvagkes
      481 rgargvrvdf wwrrlraslr ltvwapllpl rieltdttle qvrgwrvpgp aegpaepaae
      541 asdeaerrar gchlqyqrag vrflapfaah pldggrrlth llgpdwlldv shlvapharv
      601 ldsrvasleg grvvvgrepg vtsievrspl sdsilgeqal avtddkvsvl elrvqpvmgi
      661 sltlsrgtah pgevtatcwa qsalpapkqe valslwlsfs dhtvapaely drrdlglsvs
      721 aeepgailpa eeqgaqlgvv vsgagaeglp lhvalhppep crrgrhrvpl asgtawlglp
      781 pastpapalp sspawsppat eatmggkrqv agsvggntgv rgkferaeee arkeeteare
      841 eeeeeeeemv papqhvtele lgmyallgvf cvaififlvn gvvfvlryqr keppdsatdp
      901 tspqphnwvw lgtdqeelsr qldrqspgpp kgegscpces ggggeaptla pgppggttss
      961 sstlarkeag grrkrvefvt fvpappaqsp eepvgapavq silvageedi rwvcedmglk
     1021 dpeelrnyme rirgss
//
LOCUS       XP_054225195             195 aa            linear   PRI 05-AUG-2025
DEFINITION  phospholipase A and acyltransferase 2 isoform X1 [Homo sapiens].
ACCESSION   XP_054225195
VERSION     XP_054225195.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369220.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..195
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..195
                     /product="phospholipase A and acyltransferase 2 isoform
                     X1"
                     /calculated_mol_wt=21231
     Region          52..158
                     /region_name="LRAT"
                     /note="Lecithin retinol acyltransferase; pfam04970"
                     /db_xref="CDD:398571"
     CDS             1..195
                     /gene="PLAAT2"
                     /gene_synonym="HRASLS2; PLA1/2-2; PLAAT-2"
                     /coded_by="XM_054369220.1:411..998"
                     /db_xref="GeneID:54979"
                     /db_xref="HGNC:HGNC:17824"
                     /db_xref="MIM:613866"
ORIGIN      
        1 mqnccgsqrv fqfwlqsici ptlklfvclf vyslkrarpr prlgdlieis rfgyahwaiy
       61 vgdgyvvhla paseiagaga asvlsaltnk aivkkellsv vaggdnyrvn nkhddrytpl
      121 psnkivkrae elvgqelpys ltsdncehfv nhlrygvsrs dqvtgavttv gvaagllaaa
      181 slvgillars krerq
//
LOCUS       XP_054225196             976 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin carboxyl-terminal hydrolase 47 isoform X1 [Homo sapiens].
ACCESSION   XP_054225196
VERSION     XP_054225196.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369221.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..976
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..976
                     /product="ubiquitin carboxyl-terminal hydrolase 47 isoform
                     X1"
                     /calculated_mol_wt=111251
     Region          <1..167
                     /region_name="Peptidase_C19"
                     /note="Peptidase C19 contains ubiquitinyl hydrolases. They
                     are intracellular peptidases that remove ubiquitin
                     molecules from polyubiquinated peptides by cleavage of
                     isopeptide bonds. They hydrolyse bonds involving the
                     carboxyl group of the C-terminal Gly...; cl02553"
                     /db_xref="CDD:470612"
     Region          <435..>626
                     /region_name="MSCRAMM_ClfA"
                     /note="MSCRAMM family adhesin clumping factor ClfA;
                     NF033609"
                     /db_xref="CDD:468110"
     Region          725..964
                     /region_name="USP47_C"
                     /note="Ubiquitin carboxyl-terminal hydrolase 47
                     C-terminal; pfam19718"
                     /db_xref="CDD:466158"
     CDS             1..976
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /coded_by="XM_054369221.1:1296..4226"
                     /db_xref="GeneID:55031"
                     /db_xref="HGNC:HGNC:20076"
                     /db_xref="MIM:614460"
ORIGIN      
        1 mhriklndrm tfpeeldmst fidvedeksp qtesctdsga enegschsdq msndfsnddg
       61 vdegicletn sgtekisksg leknsliyel fsvmvhsgsa agghyyacik sfsdeqwysf
      121 ndqhvsritq edikkthggs sgsrgyyssa fasstnayml iyrlkdparn akflevdeyp
      181 ehiknlvqke releeqekrq reierntcki klfclhptkq vmmenklevh kdktlkeave
      241 maykmmdlee vipldccrlv kydefhdyle rsyegeedtp mglllggvks tymfdlllet
      301 rkpdqvfqsy kpgevmvkvh vvdlkaesva apitvrayln qtvtefkqli skaihlpaet
      361 mrivlercyn dlrllsvssk tlkaegffrs nkvfvesset ldyqmafads hlwklldrha
      421 ntirlfvllp eqspvsyskr tayqkaggds gnvdddcerv kgpvgslksv eaileestek
      481 lkslslqqqq dgdngdssks tetsdfenie splnerdssa svdnreleqh iqtsdpenfq
      541 seersdsdvn ndrstssvds dilssshssd tlcnadnaqi plangldshs itssrrtkan
      601 egkketwdta eedsgtdsey desgksrgem qymyfkaepy aadegsgegh kwlmvhvdkr
      661 itlaafkqhl epfvgvlssh fkvfrvyasn qefesvrlne tlssfsddnk itirlgralk
      721 kgeyrvkvyq llvneqepck flldavfakg mtvrqskeel ipqlreqcgl elsidrfrlr
      781 kktwknpgtv fldyhiyeed inissnwevf levldgvekm ksmsqlavls rrwkpsemkl
      841 dpfqevvles ssvdelrekl seisgipldd iefakgrgtf pcdisvldih qdldwnpkvs
      901 tlnvwplyic ddgavifyrd kteelmeltd eqrnelmkke ssrlqktghr vtysprkeka
      961 lkiyldgapn kdltqd
//
LOCUS       XP_054225197             976 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin carboxyl-terminal hydrolase 47 isoform X1 [Homo sapiens].
ACCESSION   XP_054225197
VERSION     XP_054225197.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369222.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..976
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..976
                     /product="ubiquitin carboxyl-terminal hydrolase 47 isoform
                     X1"
                     /calculated_mol_wt=111251
     Region          <1..167
                     /region_name="Peptidase_C19"
                     /note="Peptidase C19 contains ubiquitinyl hydrolases. They
                     are intracellular peptidases that remove ubiquitin
                     molecules from polyubiquinated peptides by cleavage of
                     isopeptide bonds. They hydrolyse bonds involving the
                     carboxyl group of the C-terminal Gly...; cl02553"
                     /db_xref="CDD:470612"
     Region          <435..>626
                     /region_name="MSCRAMM_ClfA"
                     /note="MSCRAMM family adhesin clumping factor ClfA;
                     NF033609"
                     /db_xref="CDD:468110"
     Region          725..964
                     /region_name="USP47_C"
                     /note="Ubiquitin carboxyl-terminal hydrolase 47
                     C-terminal; pfam19718"
                     /db_xref="CDD:466158"
     CDS             1..976
                     /gene="USP47"
                     /gene_synonym="TRFP"
                     /coded_by="XM_054369222.1:3662..6592"
                     /db_xref="GeneID:55031"
                     /db_xref="HGNC:HGNC:20076"
                     /db_xref="MIM:614460"
ORIGIN      
        1 mhriklndrm tfpeeldmst fidvedeksp qtesctdsga enegschsdq msndfsnddg
       61 vdegicletn sgtekisksg leknsliyel fsvmvhsgsa agghyyacik sfsdeqwysf
      121 ndqhvsritq edikkthggs sgsrgyyssa fasstnayml iyrlkdparn akflevdeyp
      181 ehiknlvqke releeqekrq reierntcki klfclhptkq vmmenklevh kdktlkeave
      241 maykmmdlee vipldccrlv kydefhdyle rsyegeedtp mglllggvks tymfdlllet
      301 rkpdqvfqsy kpgevmvkvh vvdlkaesva apitvrayln qtvtefkqli skaihlpaet
      361 mrivlercyn dlrllsvssk tlkaegffrs nkvfvesset ldyqmafads hlwklldrha
      421 ntirlfvllp eqspvsyskr tayqkaggds gnvdddcerv kgpvgslksv eaileestek
      481 lkslslqqqq dgdngdssks tetsdfenie splnerdssa svdnreleqh iqtsdpenfq
      541 seersdsdvn ndrstssvds dilssshssd tlcnadnaqi plangldshs itssrrtkan
      601 egkketwdta eedsgtdsey desgksrgem qymyfkaepy aadegsgegh kwlmvhvdkr
      661 itlaafkqhl epfvgvlssh fkvfrvyasn qefesvrlne tlssfsddnk itirlgralk
      721 kgeyrvkvyq llvneqepck flldavfakg mtvrqskeel ipqlreqcgl elsidrfrlr
      781 kktwknpgtv fldyhiyeed inissnwevf levldgvekm ksmsqlavls rrwkpsemkl
      841 dpfqevvles ssvdelrekl seisgipldd iefakgrgtf pcdisvldih qdldwnpkvs
      901 tlnvwplyic ddgavifyrd kteelmeltd eqrnelmkke ssrlqktghr vtysprkeka
      961 lkiyldgapn kdltqd
//
LOCUS       XP_054225198             355 aa            linear   PRI 05-AUG-2025
DEFINITION  vacuolar protein sorting-associated protein 37C isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225198
VERSION     XP_054225198.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369223.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..355
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..355
                     /product="vacuolar protein sorting-associated protein 37C
                     isoform X1"
                     /calculated_mol_wt=38502
     Region          5..149
                     /region_name="Mod_r"
                     /note="Modifier of rudimentary (Mod(r)) protein;
                     pfam07200"
                     /db_xref="CDD:462117"
     Region          <187..>326
                     /region_name="PRK12323"
                     /note="DNA polymerase III subunit gamma/tau; cl46901"
                     /db_xref="CDD:481241"
     CDS             1..355
                     /gene="VPS37C"
                     /coded_by="XM_054369223.1:197..1264"
                     /db_xref="GeneID:55048"
                     /db_xref="HGNC:HGNC:26097"
                     /db_xref="MIM:610038"
ORIGIN      
        1 metlkdktlq eleelqndse aidqlalesp evqdlqlere malatnrsla ernlefqgpl
       61 eisrsnlsdr yqelrklver cqeqkaklek fssalqpgtl ldllqvegmk ieeeseamae
      121 kflegevple tflenfssmr mlshlrrvrv eklqevvrkp rasqelagda ppprppppvr
      181 pvpqgtppvv eeqpqppsam ppyplpysps pslpvgptah galppapfpv vsqpsfysgp
      241 lgptypaaql gprgaagysw spqrsmpprp gypgtpmgas gpgyplrggr apspgypqqs
      301 pypatggkpp ypiqpqlpsf pgqpqpsvpl qppyppgpap pygfppppgp awpgy
//
LOCUS       XP_054225199             160 aa            linear   PRI 05-AUG-2025
DEFINITION  vacuolar protein sorting-associated protein 37C isoform X2 [Homo
            sapiens].
ACCESSION   XP_054225199
VERSION     XP_054225199.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369224.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..160
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..160
                     /product="vacuolar protein sorting-associated protein 37C
                     isoform X2"
                     /calculated_mol_wt=17895
     Region          5..>116
                     /region_name="Mod_r"
                     /note="Modifier of rudimentary (Mod(r)) protein;
                     pfam07200"
                     /db_xref="CDD:462117"
     CDS             1..160
                     /gene="VPS37C"
                     /coded_by="XM_054369224.1:43..525"
                     /db_xref="GeneID:55048"
                     /db_xref="HGNC:HGNC:26097"
                     /db_xref="MIM:610038"
ORIGIN      
        1 metlkdktlq eleelqndse aidqlalesp evqdlqlere malatnrsla ernlefqgpl
       61 eisrsnlsdr yqelrklver cqeqkaklek fssalqpgtl ldllqvegmk ieeesevrgr
      121 gdtplpwtgc qslqqgpleg eadvckawnk gafvdgrghg
//
LOCUS       XP_054225200             160 aa            linear   PRI 05-AUG-2025
DEFINITION  vacuolar protein sorting-associated protein 37C isoform X2 [Homo
            sapiens].
ACCESSION   XP_054225200
VERSION     XP_054225200.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369225.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..160
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..160
                     /product="vacuolar protein sorting-associated protein 37C
                     isoform X2"
                     /calculated_mol_wt=17895
     Region          5..>116
                     /region_name="Mod_r"
                     /note="Modifier of rudimentary (Mod(r)) protein;
                     pfam07200"
                     /db_xref="CDD:462117"
     CDS             1..160
                     /gene="VPS37C"
                     /coded_by="XM_054369225.1:83..565"
                     /db_xref="GeneID:55048"
                     /db_xref="HGNC:HGNC:26097"
                     /db_xref="MIM:610038"
ORIGIN      
        1 metlkdktlq eleelqndse aidqlalesp evqdlqlere malatnrsla ernlefqgpl
       61 eisrsnlsdr yqelrklver cqeqkaklek fssalqpgtl ldllqvegmk ieeesevrgr
      121 gdtplpwtgc qslqqgpleg eadvckawnk gafvdgrghg
//
LOCUS       XP_054225201            1007 aa            linear   PRI 05-AUG-2025
DEFINITION  anoctamin-1 isoform X1 [Homo sapiens].
ACCESSION   XP_054225201
VERSION     XP_054225201.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369226.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1007
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1007
                     /product="anoctamin-1 isoform X1"
                     /calculated_mol_wt=116266
     Region          54..339
                     /region_name="Anoct_dimer"
                     /note="dimerization domain of Ca+-activated
                     chloride-channel, anoctamin; pfam16178"
                     /db_xref="CDD:465044"
     Region          342..947
                     /region_name="Anoctamin"
                     /note="Calcium-activated chloride channel; pfam04547"
                     /db_xref="CDD:461349"
     CDS             1..1007
                     /gene="ANO1"
                     /gene_synonym="DOG1; INDMS; MYMY7; ORAOV2; TAOS2; TMEM16A"
                     /coded_by="XM_054369226.1:66..3089"
                     /db_xref="GeneID:55107"
                     /db_xref="HGNC:HGNC:21625"
                     /db_xref="MIM:610108"
ORIGIN      
        1 mrvnekystl paedrsvhii nicaiedigy lpsegtllns lsvdpdaeck yglyfrdgrr
       61 kvdyilvyhh krpsgnrtlv rrvqhsdtps garsvkqdhp lpgkgaslda gsgeppmdyh
      121 eddkrfrree yegnlleagl elerdedtki hgvgfvkiha pwnvlcreae flklkmptkk
      181 myhinetrgl lkkinsvlqk itdpiqpkva ehrpqtmkrl sypfsrekqh lfdlsdkdsf
      241 fdsktrstiv yeilkrttct kakysmgqge grkkdsalls krrkcgkygi tsllangvya
      301 aayplhdgdy ngenvefndr kllyeewary gvfykyqpid lvrkyfgeki glyfawlgvy
      361 tqmlipasiv giivflygca tmdenipsme mcdqrhnitm cplcdktcsy wkmssacata
      421 rashlfdnpa tvffsvfmal waatfmehwk rkqmrlnyrw dltgfeeeea vkdhpraeye
      481 arvlekslkk esrnkekrrh ipeestnkwk qrvktamagv kltdkvkltw rdrfpayltn
      541 lvsiifmiav tfaivlgvii yrismaaala mnsspsvrsn irvtvtatav iinlvviill
      601 devygciarw ltkievpkte ksfeerlifk afllkfvnsy tpifyvaffk grfvgrpgdy
      661 vyifrsfrme ecapggclme lciqlsiiml gkqliqnnlf eigipkmkkl irylklkqqs
      721 ppdheecvkr kqryevdynl epfagltpey memiiqfgfv tlfvasfpla plfallnnii
      781 eirldakkfv telrrpvavr akdigiwyni lrgigklavi inafvisfts dfiprlvyly
      841 myskngtmhg fvnhtlssfn vsdfqngtap ndpldlgyev qicrykdyre ppwsenkydi
      901 skdfwavlaa rlafvivfqn lvmfmsdfvd wvipdipkdi sqqihkekvl mvelfmreeq
      961 dkqqlletwm ekerqkdepp cnhhntkacp dslgspapsh ayhggvl
//
LOCUS       XP_054225202            1004 aa            linear   PRI 05-AUG-2025
DEFINITION  anoctamin-1 isoform X2 [Homo sapiens].
ACCESSION   XP_054225202
VERSION     XP_054225202.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369227.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1004
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1004
                     /product="anoctamin-1 isoform X2"
                     /calculated_mol_wt=115968
     Region          54..339
                     /region_name="Anoct_dimer"
                     /note="dimerization domain of Ca+-activated
                     chloride-channel, anoctamin; pfam16178"
                     /db_xref="CDD:465044"
     Region          342..944
                     /region_name="Anoctamin"
                     /note="Calcium-activated chloride channel; pfam04547"
                     /db_xref="CDD:461349"
     CDS             1..1004
                     /gene="ANO1"
                     /gene_synonym="DOG1; INDMS; MYMY7; ORAOV2; TAOS2; TMEM16A"
                     /coded_by="XM_054369227.1:66..3080"
                     /db_xref="GeneID:55107"
                     /db_xref="HGNC:HGNC:21625"
                     /db_xref="MIM:610108"
ORIGIN      
        1 mrvnekystl paedrsvhii nicaiedigy lpsegtllns lsvdpdaeck yglyfrdgrr
       61 kvdyilvyhh krpsgnrtlv rrvqhsdtps garsvkqdhp lpgkgaslda gsgeppmdyh
      121 eddkrfrree yegnlleagl elerdedtki hgvgfvkiha pwnvlcreae flklkmptkk
      181 myhinetrgl lkkinsvlqk itdpiqpkva ehrpqtmkrl sypfsrekqh lfdlsdkdsf
      241 fdsktrstiv yeilkrttct kakysmgqge grkkdsalls krrkcgkygi tsllangvya
      301 aayplhdgdy ngenvefndr kllyeewary gvfykyqpid lvrkyfgeki glyfawlgvy
      361 tqmlipasiv giivflygca tmdenipsme mcdqrhnitm cplcdktcsy wkmssacata
      421 rashlfdnpa tvffsvfmal waatfmehwk rkqmrlnyrw dltgfeeeed hpraeyearv
      481 lekslkkesr nkekrrhipe estnkwkqrv ktamagvklt dkvkltwrdr fpayltnlvs
      541 iifmiavtfa ivlgviiyri smaaalamns spsvrsnirv tvtataviin lvviilldev
      601 ygciarwltk ievpkteksf eerlifkafl lkfvnsytpi fyvaffkgrf vgrpgdyvyi
      661 frsfrmeeca pggclmelci qlsiimlgkq liqnnlfeig ipkmkkliry lklkqqsppd
      721 heecvkrkqr yevdynlepf agltpeymem iiqfgfvtlf vasfplaplf allnniieir
      781 ldakkfvtel rrpvavrakd igiwynilrg igklaviina fvisftsdfi prlvylymys
      841 kngtmhgfvn htlssfnvsd fqngtapndp ldlgyevqic rykdyreppw senkydiskd
      901 fwavlaarla fvivfqnlvm fmsdfvdwvi pdipkdisqq ihkekvlmve lfmreeqdkq
      961 qlletwmeke rqkdeppcnh hntkacpdsl gspapshayh ggvl
//
LOCUS       XP_054225203            1027 aa            linear   PRI 05-AUG-2025
DEFINITION  anoctamin-1 isoform X13 [Homo sapiens].
ACCESSION   XP_054225203
VERSION     XP_054225203.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369228.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1027
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1027
                     /product="anoctamin-1 isoform X13"
                     /calculated_mol_wt=117802
     Region          95..358
                     /region_name="Anoct_dimer"
                     /note="dimerization domain of Ca+-activated
                     chloride-channel, anoctamin; pfam16178"
                     /db_xref="CDD:465044"
     Region          361..967
                     /region_name="Anoctamin"
                     /note="Calcium-activated chloride channel; pfam04547"
                     /db_xref="CDD:461349"
     CDS             1..1027
                     /gene="ANO1"
                     /gene_synonym="DOG1; INDMS; MYMY7; ORAOV2; TAOS2; TMEM16A"
                     /coded_by="XM_054369228.1:203..3286"
                     /db_xref="GeneID:55107"
                     /db_xref="HGNC:HGNC:21625"
                     /db_xref="MIM:610108"
ORIGIN      
        1 mqegdigleg lpprevptae aagavdgega ppggpsaqaa tmrvnekyst lpaedrsvhi
       61 inicaiedig ylpsegtlln slsvdpdaec kyglyfrdgr rkvdyilvyh hkrpsgnrtl
      121 vrrvqhsdtp sgarsvkqdh plpgkgasld agsgeppmdy heddkrfrre eyegnlleag
      181 lelerdedtk ihgvgfvkih apwnvlcrea eflklkmptk kmyhinetrg llkkinsvlq
      241 kitdpiqpkv aehrpqtmkr lsypfsrekq hlfdlsdkds ffdsktrsti vyeilkrttc
      301 tkakysmgit sllangvyaa ayplhdgdyn genvefndrk llyeewaryg vfykyqpidl
      361 vrkyfgekig lyfawlgvyt qmlipasivg iivflygcat mdenipsmem cdqrhnitmc
      421 plcdktcsyw kmssacatar ashlfdnpat vffsvfmalw aatfmehwkr kqmrlnyrwd
      481 ltgfeeeeea vkdhpraeye arvlekslkk esrnkekrrh ipeestnkwk qrvktamagv
      541 kltdkvkltw rdrfpayltn lvsiifmiav tfaivlgvii yrismaaala mnsspsvrsn
      601 irvtvtatav iinlvviill devygciarw ltkievpkte ksfeerlifk afllkfvnsy
      661 tpifyvaffk grfvgrpgdy vyifrsfrme ecapggclme lciqlsiiml gkqliqnnlf
      721 eigipkmkkl irylklkqqs ppdheecvkr kqryevdynl epfagltpey memiiqfgfv
      781 tlfvasfpla plfallnnii eirldakkfv telrrpvavr akdigiwyni lrgigklavi
      841 inafvisfts dfiprlvyly myskngtmhg fvnhtlssfn vsdfqngtap ndpldlgyev
      901 qicrykdyre ppwsenkydi skdfwavlaa rlafvivfqn lvmfmsdfvd wvipdipkdi
      961 sqqihkekvl mvelfmreeq dkqqlletwm ekerqkdepp cnhhntkacp dslgspapsh
     1021 ayhggvl
//
LOCUS       XP_054225204            1019 aa            linear   PRI 05-AUG-2025
DEFINITION  anoctamin-1 isoform X3 [Homo sapiens].
ACCESSION   XP_054225204
VERSION     XP_054225204.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369229.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1019
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1019
                     /product="anoctamin-1 isoform X3"
                     /calculated_mol_wt=116748
     Region          95..380
                     /region_name="Anoct_dimer"
                     /note="dimerization domain of Ca+-activated
                     chloride-channel, anoctamin; pfam16178"
                     /db_xref="CDD:465044"
     Region          383..959
                     /region_name="Anoctamin"
                     /note="Calcium-activated chloride channel; pfam04547"
                     /db_xref="CDD:461349"
     CDS             1..1019
                     /gene="ANO1"
                     /gene_synonym="DOG1; INDMS; MYMY7; ORAOV2; TAOS2; TMEM16A"
                     /coded_by="XM_054369229.1:203..3262"
                     /db_xref="GeneID:55107"
                     /db_xref="HGNC:HGNC:21625"
                     /db_xref="MIM:610108"
ORIGIN      
        1 mqegdigleg lpprevptae aagavdgega ppggpsaqaa tmrvnekyst lpaedrsvhi
       61 inicaiedig ylpsegtlln slsvdpdaec kyglyfrdgr rkvdyilvyh hkrpsgnrtl
      121 vrrvqhsdtp sgarsvkqdh plpgkgasld agsgeppmdy heddkrfrre eyegnlleag
      181 lelerdedtk ihgvgfvkih apwnvlcrea eflklkmptk kmyhinetrg llkkinsvlq
      241 kitdpiqpkv aehrpqtmkr lsypfsrekq hlfdlsdkds ffdsktrsti vyeilkrttc
      301 tkakysmgqg egrkkdsall skrrkcgkyg itsllangvy aaayplhdgd yngenvefnd
      361 rkllyeewar ygvfykyqpi dlvrkyfgek iglyfawlgv ytqmlipasi vgiivflygc
      421 atmdenipsm emcdqrhnit mcplcdktcs ywkmssacat arashlfdnp atvffsvfma
      481 lwaatfmehw krkqmrlnyr wdltgfeeee dhpraeyear vlekslkkes rnketdkvkl
      541 twrdrfpayl tnlvsiifmi avtfaivlgv iiyrismaaa lamnsspsvr snirvtvtat
      601 aviinlvvii lldevygcia rwltkievpk teksfeerli fkafllkfvn sytpifyvaf
      661 fkgrfvgrpg dyvyifrsfr meecapggcl melciqlsii mlgkqliqnn lfeigipkmk
      721 klirylklkq qsppdheecv krkqryevdy nlepfagltp eymemiiqfg fvtlfvasfp
      781 laplfallnn iieirldakk fvtelrrpva vrakdigiwy nilrgigkla viinafvisf
      841 tsdfiprlvy lymyskngtm hgfvnhtlss fnvsdfqngt apndpldlgy evqicrykdy
      901 reppwsenky diskdfwavl aarlafvivf qnlvmfmsdf vdwvipdipk disqqihkek
      961 vlmvelfmre eqdkqqllet wmekerqkde ppcnhhntka cpdslgspap shayhggvl
//
LOCUS       XP_054225205             960 aa            linear   PRI 05-AUG-2025
DEFINITION  anoctamin-1 isoform X4 [Homo sapiens].
ACCESSION   XP_054225205
VERSION     XP_054225205.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369230.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..960
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..960
                     /product="anoctamin-1 isoform X4"
                     /calculated_mol_wt=110873
     Region          54..317
                     /region_name="Anoct_dimer"
                     /note="dimerization domain of Ca+-activated
                     chloride-channel, anoctamin; pfam16178"
                     /db_xref="CDD:465044"
     Region          320..900
                     /region_name="Anoctamin"
                     /note="Calcium-activated chloride channel; pfam04547"
                     /db_xref="CDD:461349"
     CDS             1..960
                     /gene="ANO1"
                     /gene_synonym="DOG1; INDMS; MYMY7; ORAOV2; TAOS2; TMEM16A"
                     /coded_by="XM_054369230.1:66..2948"
                     /db_xref="GeneID:55107"
                     /db_xref="HGNC:HGNC:21625"
                     /db_xref="MIM:610108"
ORIGIN      
        1 mrvnekystl paedrsvhii nicaiedigy lpsegtllns lsvdpdaeck yglyfrdgrr
       61 kvdyilvyhh krpsgnrtlv rrvqhsdtps garsvkqdhp lpgkgaslda gsgeppmdyh
      121 eddkrfrree yegnlleagl elerdedtki hgvgfvkiha pwnvlcreae flklkmptkk
      181 myhinetrgl lkkinsvlqk itdpiqpkva ehrpqtmkrl sypfsrekqh lfdlsdkdsf
      241 fdsktrstiv yeilkrttct kakysmgits llangvyaaa yplhdgdyng envefndrkl
      301 lyeewarygv fykyqpidlv rkyfgekigl yfawlgvytq mlipasivgi ivflygcatm
      361 denipsmemc dqrhnitmcp lcdktcsywk mssacatara shlfdnpatv ffsvfmalwa
      421 atfmehwkrk qmrlnyrwdl tgfeeeeeav kdhpraeyea rvlekslkke srnketdkvk
      481 ltwrdrfpay ltnlvsiifm iavtfaivlg viiyrismaa alamnsspsv rsnirvtvta
      541 taviinlvvi illdevygci arwltkievp kteksfeerl ifkafllkfv nsytpifyva
      601 ffkgrfvgrp gdyvyifrsf rmeecapggc lmelciqlsi imlgkqliqn nlfeigipkm
      661 kklirylklk qqsppdheec vkrkqryevd ynlepfaglt peymemiiqf gfvtlfvasf
      721 plaplfalln niieirldak kfvtelrrpv avrakdigiw ynilrgigkl aviinafvis
      781 ftsdfiprlv ylymyskngt mhgfvnhtls sfnvsdfqng tapndpldlg yevqicrykd
      841 yreppwsenk ydiskdfwav laarlafviv fqnlvmfmsd fvdwvipdip kdisqqihke
      901 kvlmvelfmr eeqdkqqlle twmekerqkd eppcnhhntk acpdslgspa pshayhggvl
//
LOCUS       XP_054225206            1008 aa            linear   PRI 05-AUG-2025
DEFINITION  anoctamin-1 isoform X5 [Homo sapiens].
ACCESSION   XP_054225206
VERSION     XP_054225206.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369231.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1008
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1008
                     /product="anoctamin-1 isoform X5"
                     /calculated_mol_wt=116396
     Region          54..339
                     /region_name="Anoct_dimer"
                     /note="dimerization domain of Ca+-activated
                     chloride-channel, anoctamin; pfam16178"
                     /db_xref="CDD:465044"
     Region          342..948
                     /region_name="Anoctamin"
                     /note="Calcium-activated chloride channel; pfam04547"
                     /db_xref="CDD:461349"
     CDS             1..1008
                     /gene="ANO1"
                     /gene_synonym="DOG1; INDMS; MYMY7; ORAOV2; TAOS2; TMEM16A"
                     /coded_by="XM_054369231.1:138..3164"
                     /db_xref="GeneID:55107"
                     /db_xref="HGNC:HGNC:21625"
                     /db_xref="MIM:610108"
ORIGIN      
        1 mrvnekystl paedrsvhii nicaiedigy lpsegtllns lsvdpdaeck yglyfrdgrr
       61 kvdyilvyhh krpsgnrtlv rrvqhsdtps garsvkqdhp lpgkgaslda gsgeppmdyh
      121 eddkrfrree yegnlleagl elerdedtki hgvgfvkiha pwnvlcreae flklkmptkk
      181 myhinetrgl lkkinsvlqk itdpiqpkva ehrpqtmkrl sypfsrekqh lfdlsdkdsf
      241 fdsktrstiv yeilkrttct kakysmgqge grkkdsalls krrkcgkygi tsllangvya
      301 aayplhdgdy ngenvefndr kllyeewary gvfykyqpid lvrkyfgeki glyfawlgvy
      361 tqmlipasiv giivflygca tmdenipsme mcdqrhnitm cplcdktcsy wkmssacata
      421 rashlfdnpa tvffsvfmal waatfmehwk rkqmrlnyrw dltgfeeeee avkdhpraey
      481 earvlekslk kesrnkekrr hipeestnkw kqrvktamag vkltdkvklt wrdrfpaylt
      541 nlvsiifmia vtfaivlgvi iyrismaaal amnsspsvrs nirvtvtata viinlvviil
      601 ldevygciar wltkievpkt eksfeerlif kafllkfvns ytpifyvaff kgrfvgrpgd
      661 yvyifrsfrm eecapggclm elciqlsiim lgkqliqnnl feigipkmkk lirylklkqq
      721 sppdheecvk rkqryevdyn lepfagltpe ymemiiqfgf vtlfvasfpl aplfallnni
      781 ieirldakkf vtelrrpvav rakdigiwyn ilrgigklav iinafvisft sdfiprlvyl
      841 ymyskngtmh gfvnhtlssf nvsdfqngta pndpldlgye vqicrykdyr eppwsenkyd
      901 iskdfwavla arlafvivfq nlvmfmsdfv dwvipdipkd isqqihkekv lmvelfmree
      961 qdkqqlletw mekerqkdep pcnhhntkac pdslgspaps hayhggvl
//
LOCUS       XP_054225207             997 aa            linear   PRI 05-AUG-2025
DEFINITION  anoctamin-1 isoform X6 [Homo sapiens].
ACCESSION   XP_054225207
VERSION     XP_054225207.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369232.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..997
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..997
                     /product="anoctamin-1 isoform X6"
                     /calculated_mol_wt=114300
     Region          95..358
                     /region_name="Anoct_dimer"
                     /note="dimerization domain of Ca+-activated
                     chloride-channel, anoctamin; pfam16178"
                     /db_xref="CDD:465044"
     Region          361..937
                     /region_name="Anoctamin"
                     /note="Calcium-activated chloride channel; pfam04547"
                     /db_xref="CDD:461349"
     CDS             1..997
                     /gene="ANO1"
                     /gene_synonym="DOG1; INDMS; MYMY7; ORAOV2; TAOS2; TMEM16A"
                     /coded_by="XM_054369232.1:203..3196"
                     /db_xref="GeneID:55107"
                     /db_xref="HGNC:HGNC:21625"
                     /db_xref="MIM:610108"
ORIGIN      
        1 mqegdigleg lpprevptae aagavdgega ppggpsaqaa tmrvnekyst lpaedrsvhi
       61 inicaiedig ylpsegtlln slsvdpdaec kyglyfrdgr rkvdyilvyh hkrpsgnrtl
      121 vrrvqhsdtp sgarsvkqdh plpgkgasld agsgeppmdy heddkrfrre eyegnlleag
      181 lelerdedtk ihgvgfvkih apwnvlcrea eflklkmptk kmyhinetrg llkkinsvlq
      241 kitdpiqpkv aehrpqtmkr lsypfsrekq hlfdlsdkds ffdsktrsti vyeilkrttc
      301 tkakysmgit sllangvyaa ayplhdgdyn genvefndrk llyeewaryg vfykyqpidl
      361 vrkyfgekig lyfawlgvyt qmlipasivg iivflygcat mdenipsmem cdqrhnitmc
      421 plcdktcsyw kmssacatar ashlfdnpat vffsvfmalw aatfmehwkr kqmrlnyrwd
      481 ltgfeeeedh praeyearvl ekslkkesrn ketdkvkltw rdrfpayltn lvsiifmiav
      541 tfaivlgvii yrismaaala mnsspsvrsn irvtvtatav iinlvviill devygciarw
      601 ltkievpkte ksfeerlifk afllkfvnsy tpifyvaffk grfvgrpgdy vyifrsfrme
      661 ecapggclme lciqlsiiml gkqliqnnlf eigipkmkkl irylklkqqs ppdheecvkr
      721 kqryevdynl epfagltpey memiiqfgfv tlfvasfpla plfallnnii eirldakkfv
      781 telrrpvavr akdigiwyni lrgigklavi inafvisfts dfiprlvyly myskngtmhg
      841 fvnhtlssfn vsdfqngtap ndpldlgyev qicrykdyre ppwsenkydi skdfwavlaa
      901 rlafvivfqn lvmfmsdfvd wvipdipkdi sqqihkekvl mvelfmreeq dkqqlletwm
      961 ekerqkdepp cnhhntkacp dslgspapsh ayhggvl
//
LOCUS       XP_054225208            1005 aa            linear   PRI 05-AUG-2025
DEFINITION  anoctamin-1 isoform X7 [Homo sapiens].
ACCESSION   XP_054225208
VERSION     XP_054225208.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369233.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1005
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1005
                     /product="anoctamin-1 isoform X7"
                     /calculated_mol_wt=115345
     Region          103..366
                     /region_name="Anoct_dimer"
                     /note="dimerization domain of Ca+-activated
                     chloride-channel, anoctamin; pfam16178"
                     /db_xref="CDD:465044"
     Region          369..945
                     /region_name="Anoctamin"
                     /note="Calcium-activated chloride channel; pfam04547"
                     /db_xref="CDD:461349"
     CDS             1..1005
                     /gene="ANO1"
                     /gene_synonym="DOG1; INDMS; MYMY7; ORAOV2; TAOS2; TMEM16A"
                     /coded_by="XM_054369233.1:568..3585"
                     /db_xref="GeneID:55107"
                     /db_xref="HGNC:HGNC:21625"
                     /db_xref="MIM:610108"
ORIGIN      
        1 mweasgmeer ameelameet aldpllaeaa gavdgegapp ggpsaqaatm rvnekystlp
       61 aedrsvhiin icaiedigyl psegtllnsl svdpdaecky glyfrdgrrk vdyilvyhhk
      121 rpsgnrtlvr rvqhsdtpsg arsvkqdhpl pgkgasldag sgeppmdyhe ddkrfrreey
      181 egnlleagle lerdedtkih gvgfvkihap wnvlcreaef lklkmptkkm yhinetrgll
      241 kkinsvlqki tdpiqpkvae hrpqtmkrls ypfsrekqhl fdlsdkdsff dsktrstivy
      301 eilkrttctk akysmgitsl langvyaaay plhdgdynge nvefndrkll yeewarygvf
      361 ykyqpidlvr kyfgekigly fawlgvytqm lipasivgii vflygcatmd enipsmemcd
      421 qrhnitmcpl cdktcsywkm ssacataras hlfdnpatvf fsvfmalwaa tfmehwkrkq
      481 mrlnyrwdlt gfeeeedhpr aeyearvlek slkkesrnke tdkvkltwrd rfpayltnlv
      541 siifmiavtf aivlgviiyr ismaaalamn sspsvrsnir vtvtatavii nlvviillde
      601 vygciarwlt kievpkteks feerlifkaf llkfvnsytp ifyvaffkgr fvgrpgdyvy
      661 ifrsfrmeec apggclmelc iqlsiimlgk qliqnnlfei gipkmkklir ylklkqqspp
      721 dheecvkrkq ryevdynlep fagltpeyme miiqfgfvtl fvasfplapl fallnniiei
      781 rldakkfvte lrrpvavrak digiwynilr gigklaviin afvisftsdf iprlvylymy
      841 skngtmhgfv nhtlssfnvs dfqngtapnd pldlgyevqi crykdyrepp wsenkydisk
      901 dfwavlaarl afvivfqnlv mfmsdfvdwv ipdipkdisq qihkekvlmv elfmreeqdk
      961 qqlletwmek erqkdeppcn hhntkacpds lgspapshay hggvl
//
LOCUS       XP_054225209             986 aa            linear   PRI 05-AUG-2025
DEFINITION  anoctamin-1 isoform X8 [Homo sapiens].
ACCESSION   XP_054225209
VERSION     XP_054225209.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369234.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..986
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..986
                     /product="anoctamin-1 isoform X8"
                     /calculated_mol_wt=113948
     Region          54..317
                     /region_name="Anoct_dimer"
                     /note="dimerization domain of Ca+-activated
                     chloride-channel, anoctamin; pfam16178"
                     /db_xref="CDD:465044"
     Region          320..926
                     /region_name="Anoctamin"
                     /note="Calcium-activated chloride channel; pfam04547"
                     /db_xref="CDD:461349"
     CDS             1..986
                     /gene="ANO1"
                     /gene_synonym="DOG1; INDMS; MYMY7; ORAOV2; TAOS2; TMEM16A"
                     /coded_by="XM_054369234.1:138..3098"
                     /db_xref="GeneID:55107"
                     /db_xref="HGNC:HGNC:21625"
                     /db_xref="MIM:610108"
ORIGIN      
        1 mrvnekystl paedrsvhii nicaiedigy lpsegtllns lsvdpdaeck yglyfrdgrr
       61 kvdyilvyhh krpsgnrtlv rrvqhsdtps garsvkqdhp lpgkgaslda gsgeppmdyh
      121 eddkrfrree yegnlleagl elerdedtki hgvgfvkiha pwnvlcreae flklkmptkk
      181 myhinetrgl lkkinsvlqk itdpiqpkva ehrpqtmkrl sypfsrekqh lfdlsdkdsf
      241 fdsktrstiv yeilkrttct kakysmgits llangvyaaa yplhdgdyng envefndrkl
      301 lyeewarygv fykyqpidlv rkyfgekigl yfawlgvytq mlipasivgi ivflygcatm
      361 denipsmemc dqrhnitmcp lcdktcsywk mssacatara shlfdnpatv ffsvfmalwa
      421 atfmehwkrk qmrlnyrwdl tgfeeeeeav kdhpraeyea rvlekslkke srnkekrrhi
      481 peestnkwkq rvktamagvk ltdkvkltwr drfpayltnl vsiifmiavt faivlgviiy
      541 rismaaalam nsspsvrsni rvtvtatavi inlvviilld evygciarwl tkievpktek
      601 sfeerlifka fllkfvnsyt pifyvaffkg rfvgrpgdyv yifrsfrmee capggclmel
      661 ciqlsiimlg kqliqnnlfe igipkmkkli rylklkqqsp pdheecvkrk qryevdynle
      721 pfagltpeym emiiqfgfvt lfvasfplap lfallnniie irldakkfvt elrrpvavra
      781 kdigiwynil rgigklavii nafvisftsd fiprlvylym yskngtmhgf vnhtlssfnv
      841 sdfqngtapn dpldlgyevq icrykdyrep pwsenkydis kdfwavlaar lafvivfqnl
      901 vmfmsdfvdw vipdipkdis qqihkekvlm velfmreeqd kqqlletwme kerqkdeppc
      961 nhhntkacpd slgspapsha yhggvl
//
LOCUS       XP_054225210             980 aa            linear   PRI 05-AUG-2025
DEFINITION  anoctamin-1 isoform X9 [Homo sapiens].
ACCESSION   XP_054225210
VERSION     XP_054225210.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369235.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..980
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..980
                     /product="anoctamin-1 isoform X9"
                     /calculated_mol_wt=113291
     Region          26..311
                     /region_name="Anoct_dimer"
                     /note="dimerization domain of Ca+-activated
                     chloride-channel, anoctamin; pfam16178"
                     /db_xref="CDD:465044"
     Region          314..920
                     /region_name="Anoctamin"
                     /note="Calcium-activated chloride channel; pfam04547"
                     /db_xref="CDD:461349"
     CDS             1..980
                     /gene="ANO1"
                     /gene_synonym="DOG1; INDMS; MYMY7; ORAOV2; TAOS2; TMEM16A"
                     /coded_by="XM_054369235.1:107..3049"
                     /db_xref="GeneID:55107"
                     /db_xref="HGNC:HGNC:21625"
                     /db_xref="MIM:610108"
ORIGIN      
        1 mltrpsqvll nslsvdpdae ckyglyfrdg rrkvdyilvy hhkrpsgnrt lvrrvqhsdt
       61 psgarsvkqd hplpgkgasl dagsgeppmd yheddkrfrr eeyegnllea glelerdedt
      121 kihgvgfvki hapwnvlcre aeflklkmpt kkmyhinetr gllkkinsvl qkitdpiqpk
      181 vaehrpqtmk rlsypfsrek qhlfdlsdkd sffdsktrst ivyeilkrtt ctkakysmgq
      241 gegrkkdsal lskrrkcgky gitsllangv yaaayplhdg dyngenvefn drkllyeewa
      301 rygvfykyqp idlvrkyfge kiglyfawlg vytqmlipas ivgiivflyg catmdenips
      361 memcdqrhni tmcplcdktc sywkmssaca tarashlfdn patvffsvfm alwaatfmeh
      421 wkrkqmrlny rwdltgfeee eeavkdhpra eyearvleks lkkesrnkek rrhipeestn
      481 kwkqrvktam agvkltdkvk ltwrdrfpay ltnlvsiifm iavtfaivlg viiyrismaa
      541 alamnsspsv rsnirvtvta taviinlvvi illdevygci arwltkievp kteksfeerl
      601 ifkafllkfv nsytpifyva ffkgrfvgrp gdyvyifrsf rmeecapggc lmelciqlsi
      661 imlgkqliqn nlfeigipkm kklirylklk qqsppdheec vkrkqryevd ynlepfaglt
      721 peymemiiqf gfvtlfvasf plaplfalln niieirldak kfvtelrrpv avrakdigiw
      781 ynilrgigkl aviinafvis ftsdfiprlv ylymyskngt mhgfvnhtls sfnvsdfqng
      841 tapndpldlg yevqicrykd yreppwsenk ydiskdfwav laarlafviv fqnlvmfmsd
      901 fvdwvipdip kdisqqihke kvlmvelfmr eeqdkqqlle twmekerqkd eppcnhhntk
      961 acpdslgspa pshayhggvl
//
LOCUS       XP_054225211             979 aa            linear   PRI 05-AUG-2025
DEFINITION  anoctamin-1 isoform X10 [Homo sapiens].
ACCESSION   XP_054225211
VERSION     XP_054225211.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369236.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..979
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..979
                     /product="anoctamin-1 isoform X10"
                     /calculated_mol_wt=113192
     Region          25..310
                     /region_name="Anoct_dimer"
                     /note="dimerization domain of Ca+-activated
                     chloride-channel, anoctamin; pfam16178"
                     /db_xref="CDD:465044"
     Region          313..919
                     /region_name="Anoctamin"
                     /note="Calcium-activated chloride channel; pfam04547"
                     /db_xref="CDD:461349"
     CDS             1..979
                     /gene="ANO1"
                     /gene_synonym="DOG1; INDMS; MYMY7; ORAOV2; TAOS2; TMEM16A"
                     /coded_by="XM_054369236.1:16..2955"
                     /db_xref="GeneID:55107"
                     /db_xref="HGNC:HGNC:21625"
                     /db_xref="MIM:610108"
ORIGIN      
        1 mltrpsqlln slsvdpdaec kyglyfrdgr rkvdyilvyh hkrpsgnrtl vrrvqhsdtp
       61 sgarsvkqdh plpgkgasld agsgeppmdy heddkrfrre eyegnlleag lelerdedtk
      121 ihgvgfvkih apwnvlcrea eflklkmptk kmyhinetrg llkkinsvlq kitdpiqpkv
      181 aehrpqtmkr lsypfsrekq hlfdlsdkds ffdsktrsti vyeilkrttc tkakysmgqg
      241 egrkkdsall skrrkcgkyg itsllangvy aaayplhdgd yngenvefnd rkllyeewar
      301 ygvfykyqpi dlvrkyfgek iglyfawlgv ytqmlipasi vgiivflygc atmdenipsm
      361 emcdqrhnit mcplcdktcs ywkmssacat arashlfdnp atvffsvfma lwaatfmehw
      421 krkqmrlnyr wdltgfeeee eavkdhprae yearvleksl kkesrnkekr rhipeestnk
      481 wkqrvktama gvkltdkvkl twrdrfpayl tnlvsiifmi avtfaivlgv iiyrismaaa
      541 lamnsspsvr snirvtvtat aviinlvvii lldevygcia rwltkievpk teksfeerli
      601 fkafllkfvn sytpifyvaf fkgrfvgrpg dyvyifrsfr meecapggcl melciqlsii
      661 mlgkqliqnn lfeigipkmk klirylklkq qsppdheecv krkqryevdy nlepfagltp
      721 eymemiiqfg fvtlfvasfp laplfallnn iieirldakk fvtelrrpva vrakdigiwy
      781 nilrgigkla viinafvisf tsdfiprlvy lymyskngtm hgfvnhtlss fnvsdfqngt
      841 apndpldlgy evqicrykdy reppwsenky diskdfwavl aarlafvivf qnlvmfmsdf
      901 vdwvipdipk disqqihkek vlmvelfmre eqdkqqllet wmekerqkde ppcnhhntka
      961 cpdslgspap shayhggvl
//
LOCUS       XP_054225212             721 aa            linear   PRI 05-AUG-2025
DEFINITION  anoctamin-1 isoform X11 [Homo sapiens].
ACCESSION   XP_054225212
VERSION     XP_054225212.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369237.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..721
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..721
                     /product="anoctamin-1 isoform X11"
                     /calculated_mol_wt=83390
     Region          <1..52
                     /region_name="Anoct_dimer"
                     /note="dimerization domain of Ca+-activated
                     chloride-channel, anoctamin; pfam16178"
                     /db_xref="CDD:465044"
     Region          55..661
                     /region_name="Anoctamin"
                     /note="Calcium-activated chloride channel; pfam04547"
                     /db_xref="CDD:461349"
     CDS             1..721
                     /gene="ANO1"
                     /gene_synonym="DOG1; INDMS; MYMY7; ORAOV2; TAOS2; TMEM16A"
                     /coded_by="XM_054369237.1:54..2219"
                     /db_xref="GeneID:55107"
                     /db_xref="HGNC:HGNC:21625"
                     /db_xref="MIM:610108"
ORIGIN      
        1 mgitsllang vyaaayplhd gdyngenvef ndrkllyeew arygvfykyq pidlvrkyfg
       61 ekiglyfawl gvytqmlipa sivgiivfly gcatmdenip smemcdqrhn itmcplcdkt
      121 csywkmssac atarashlfd npatvffsvf malwaatfme hwkrkqmrln yrwdltgfee
      181 eeeavkdhpr aeyearvlek slkkesrnke krrhipeest nkwkqrvkta magvkltdkv
      241 kltwrdrfpa yltnlvsiif miavtfaivl gviiyrisma aalamnssps vrsnirvtvt
      301 ataviinlvv iilldevygc iarwltkiev pkteksfeer lifkafllkf vnsytpifyv
      361 affkgrfvgr pgdyvyifrs frmeecapgg clmelciqls iimlgkqliq nnlfeigipk
      421 mkklirylkl kqqsppdhee cvkrkqryev dynlepfagl tpeymemiiq fgfvtlfvas
      481 fplaplfall nniieirlda kkfvtelrrp vavrakdigi wynilrgigk laviinafvi
      541 sftsdfiprl vylymyskng tmhgfvnhtl ssfnvsdfqn gtapndpldl gyevqicryk
      601 dyreppwsen kydiskdfwa vlaarlafvi vfqnlvmfms dfvdwvipdi pkdisqqihk
      661 ekvlmvelfm reeqdkqqll etwmekerqk deppcnhhnt kacpdslgsp apshayhggv
      721 l
//
LOCUS       XP_054225213             642 aa            linear   PRI 05-AUG-2025
DEFINITION  anoctamin-1 isoform X12 [Homo sapiens].
ACCESSION   XP_054225213
VERSION     XP_054225213.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369238.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..642
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..642
                     /product="anoctamin-1 isoform X12"
                     /calculated_mol_wt=74238
     Region          26..289
                     /region_name="Anoct_dimer"
                     /note="dimerization domain of Ca+-activated
                     chloride-channel, anoctamin; pfam16178"
                     /db_xref="CDD:465044"
     Region          292..>554
                     /region_name="Anoctamin"
                     /note="Calcium-activated chloride channel; pfam04547"
                     /db_xref="CDD:461349"
     CDS             1..642
                     /gene="ANO1"
                     /gene_synonym="DOG1; INDMS; MYMY7; ORAOV2; TAOS2; TMEM16A"
                     /coded_by="XM_054369238.1:107..2035"
                     /db_xref="GeneID:55107"
                     /db_xref="HGNC:HGNC:21625"
                     /db_xref="MIM:610108"
ORIGIN      
        1 mltrpsqvll nslsvdpdae ckyglyfrdg rrkvdyilvy hhkrpsgnrt lvrrvqhsdt
       61 psgarsvkqd hplpgkgasl dagsgeppmd yheddkrfrr eeyegnllea glelerdedt
      121 kihgvgfvki hapwnvlcre aeflklkmpt kkmyhinetr gllkkinsvl qkitdpiqpk
      181 vaehrpqtmk rlsypfsrek qhlfdlsdkd sffdsktrst ivyeilkrtt ctkakysmgi
      241 tsllangvya aayplhdgdy ngenvefndr kllyeewary gvfykyqpid lvrkyfgeki
      301 glyfawlgvy tqmlipasiv giivflygca tmdenipsme mcdqrhnitm cplcdktcsy
      361 wkmssacata rashlfdnpa tvffsvfmal waatfmehwk rkqmrlnyrw dltgfeeeed
      421 hpraeyearv lekslkkesr nketdkvklt wrdrfpaylt nlvsiifmia vtfaivlgvi
      481 iyrismaaal amnsspsvrs nirvtvtata viinlvviil ldevygciar wltkievpkt
      541 eksfeerlif kafllkfvns ytpifyvaff kgrfvgrpgd yvyifrsfrm eevteilfis
      601 gspfclaydl stpctwekql qhicsakssr flsflletfl fp
//
LOCUS       XP_054225214             661 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A
            beta isoform isoform X1 [Homo sapiens].
ACCESSION   XP_054225214
VERSION     XP_054225214.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369239.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..661
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..661
                     /product="serine/threonine-protein phosphatase 2A 65 kDa
                     regulatory subunit A beta isoform isoform X1"
                     /calculated_mol_wt=72747
     Region          25..49
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Site            order(41..42,45,48..49,79..80,83,86..87,90,118..119,122,
                     125..126,129,157..158,161,164..165,195..196,199,202..203)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          63..90
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          100..130
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          102..239
                     /region_name="HEAT"
                     /note="HEAT repeat [General function prediction only];
                     COG1413"
                     /db_xref="CDD:441023"
     Region          139..165
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          175..204
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          193..364
                     /region_name="HEAT"
                     /note="HEAT repeat [General function prediction only];
                     COG1413"
                     /db_xref="CDD:441023"
     Region          216..246
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          257..281
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Site            order(273..274,277,280..281,312..313,316,319..320,323,
                     355..356,359,362..363,366,394..395,398,401..402,433..434,
                     437,440..441)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          295..323
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          337..367
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          376..402
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          378..478
                     /region_name="HEAT_2"
                     /note="HEAT repeats; pfam13646"
                     /db_xref="CDD:433376"
     Region          413..442
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          454..480
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          491..520
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          530..556
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          571..597
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     CDS             1..661
                     /gene="PPP2R1B"
                     /gene_synonym="PP2A-Abeta; PR65B"
                     /coded_by="XM_054369239.1:29..2014"
                     /db_xref="GeneID:5519"
                     /db_xref="HGNC:HGNC:9303"
                     /db_xref="MIM:603113"
ORIGIN      
        1 magaselgtg pgaaggdgdd slypiavlid elrnedvqlr lnsikklsti alalgvertr
       61 sellpfltdt iydedevlla laeqlgnftg lvggpdfahc llpplenlat veetvvrdka
      121 veslrqisqe htpvaleayf vplvkrlasg dwftsrtsac glfsvcypra snavkaeirq
      181 qfrslcsddt pmvrraaask lgefakvlel dsvkseivpl ftslasdeqd svrllaveac
      241 vsiaqllsqd dletlvmptl rqaaedkswr vrymvadrfs elqkamgpki tlndlipafq
      301 nllkdceaev raaaahkvke lgenlpiedr etiimnqilp yikelvsdtn qhvksalasv
      361 imglstilgk entiehllpl flaqlkdecp dvrlniisnl dcvnevigir qlsqsllpai
      421 velaedakwr vrlaiieymp llagqlgvef fdeklnslcm awlvdhvyai reaatnnlmk
      481 lvqkfgtewa qntivpkvlv mandpnylhr mttlfcinal seacgqeitt kqmlpivlkm
      541 agdqvanvrf nvakslqkig pildtnalqg evkpvlqklg qdedmdvkyf aqeaisvvaq
      601 rlrklefpvk dsgepsvpra dknhfprptv pgedmgkdka aqealgcvfr dpeihtiiaa
      661 l
//
LOCUS       XP_054225215             661 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A
            beta isoform isoform X1 [Homo sapiens].
ACCESSION   XP_054225215
VERSION     XP_054225215.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369240.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..661
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..661
                     /product="serine/threonine-protein phosphatase 2A 65 kDa
                     regulatory subunit A beta isoform isoform X1"
                     /calculated_mol_wt=72747
     Region          25..49
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Site            order(41..42,45,48..49,79..80,83,86..87,90,118..119,122,
                     125..126,129,157..158,161,164..165,195..196,199,202..203)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          63..90
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          100..130
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          102..239
                     /region_name="HEAT"
                     /note="HEAT repeat [General function prediction only];
                     COG1413"
                     /db_xref="CDD:441023"
     Region          139..165
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          175..204
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          193..364
                     /region_name="HEAT"
                     /note="HEAT repeat [General function prediction only];
                     COG1413"
                     /db_xref="CDD:441023"
     Region          216..246
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          257..281
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Site            order(273..274,277,280..281,312..313,316,319..320,323,
                     355..356,359,362..363,366,394..395,398,401..402,433..434,
                     437,440..441)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          295..323
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          337..367
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          376..402
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          378..478
                     /region_name="HEAT_2"
                     /note="HEAT repeats; pfam13646"
                     /db_xref="CDD:433376"
     Region          413..442
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          454..480
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          491..520
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          530..556
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          571..597
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     CDS             1..661
                     /gene="PPP2R1B"
                     /gene_synonym="PP2A-Abeta; PR65B"
                     /coded_by="XM_054369240.1:29..2014"
                     /db_xref="GeneID:5519"
                     /db_xref="HGNC:HGNC:9303"
                     /db_xref="MIM:603113"
ORIGIN      
        1 magaselgtg pgaaggdgdd slypiavlid elrnedvqlr lnsikklsti alalgvertr
       61 sellpfltdt iydedevlla laeqlgnftg lvggpdfahc llpplenlat veetvvrdka
      121 veslrqisqe htpvaleayf vplvkrlasg dwftsrtsac glfsvcypra snavkaeirq
      181 qfrslcsddt pmvrraaask lgefakvlel dsvkseivpl ftslasdeqd svrllaveac
      241 vsiaqllsqd dletlvmptl rqaaedkswr vrymvadrfs elqkamgpki tlndlipafq
      301 nllkdceaev raaaahkvke lgenlpiedr etiimnqilp yikelvsdtn qhvksalasv
      361 imglstilgk entiehllpl flaqlkdecp dvrlniisnl dcvnevigir qlsqsllpai
      421 velaedakwr vrlaiieymp llagqlgvef fdeklnslcm awlvdhvyai reaatnnlmk
      481 lvqkfgtewa qntivpkvlv mandpnylhr mttlfcinal seacgqeitt kqmlpivlkm
      541 agdqvanvrf nvakslqkig pildtnalqg evkpvlqklg qdedmdvkyf aqeaisvvaq
      601 rlrklefpvk dsgepsvpra dknhfprptv pgedmgkdka aqealgcvfr dpeihtiiaa
      661 l
//
LOCUS       XP_054225216             661 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A
            beta isoform isoform X1 [Homo sapiens].
ACCESSION   XP_054225216
VERSION     XP_054225216.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369241.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..661
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..661
                     /product="serine/threonine-protein phosphatase 2A 65 kDa
                     regulatory subunit A beta isoform isoform X1"
                     /calculated_mol_wt=72747
     Region          25..49
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Site            order(41..42,45,48..49,79..80,83,86..87,90,118..119,122,
                     125..126,129,157..158,161,164..165,195..196,199,202..203)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          63..90
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          100..130
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          102..239
                     /region_name="HEAT"
                     /note="HEAT repeat [General function prediction only];
                     COG1413"
                     /db_xref="CDD:441023"
     Region          139..165
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          175..204
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          193..364
                     /region_name="HEAT"
                     /note="HEAT repeat [General function prediction only];
                     COG1413"
                     /db_xref="CDD:441023"
     Region          216..246
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          257..281
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Site            order(273..274,277,280..281,312..313,316,319..320,323,
                     355..356,359,362..363,366,394..395,398,401..402,433..434,
                     437,440..441)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          295..323
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          337..367
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          376..402
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          378..478
                     /region_name="HEAT_2"
                     /note="HEAT repeats; pfam13646"
                     /db_xref="CDD:433376"
     Region          413..442
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          454..480
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          491..520
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          530..556
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          571..597
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     CDS             1..661
                     /gene="PPP2R1B"
                     /gene_synonym="PP2A-Abeta; PR65B"
                     /coded_by="XM_054369241.1:29..2014"
                     /db_xref="GeneID:5519"
                     /db_xref="HGNC:HGNC:9303"
                     /db_xref="MIM:603113"
ORIGIN      
        1 magaselgtg pgaaggdgdd slypiavlid elrnedvqlr lnsikklsti alalgvertr
       61 sellpfltdt iydedevlla laeqlgnftg lvggpdfahc llpplenlat veetvvrdka
      121 veslrqisqe htpvaleayf vplvkrlasg dwftsrtsac glfsvcypra snavkaeirq
      181 qfrslcsddt pmvrraaask lgefakvlel dsvkseivpl ftslasdeqd svrllaveac
      241 vsiaqllsqd dletlvmptl rqaaedkswr vrymvadrfs elqkamgpki tlndlipafq
      301 nllkdceaev raaaahkvke lgenlpiedr etiimnqilp yikelvsdtn qhvksalasv
      361 imglstilgk entiehllpl flaqlkdecp dvrlniisnl dcvnevigir qlsqsllpai
      421 velaedakwr vrlaiieymp llagqlgvef fdeklnslcm awlvdhvyai reaatnnlmk
      481 lvqkfgtewa qntivpkvlv mandpnylhr mttlfcinal seacgqeitt kqmlpivlkm
      541 agdqvanvrf nvakslqkig pildtnalqg evkpvlqklg qdedmdvkyf aqeaisvvaq
      601 rlrklefpvk dsgepsvpra dknhfprptv pgedmgkdka aqealgcvfr dpeihtiiaa
      661 l
//
LOCUS       XP_054225217             661 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A
            beta isoform isoform X1 [Homo sapiens].
ACCESSION   XP_054225217
VERSION     XP_054225217.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369242.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..661
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..661
                     /product="serine/threonine-protein phosphatase 2A 65 kDa
                     regulatory subunit A beta isoform isoform X1"
                     /calculated_mol_wt=72747
     Region          25..49
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Site            order(41..42,45,48..49,79..80,83,86..87,90,118..119,122,
                     125..126,129,157..158,161,164..165,195..196,199,202..203)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          63..90
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          100..130
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          102..239
                     /region_name="HEAT"
                     /note="HEAT repeat [General function prediction only];
                     COG1413"
                     /db_xref="CDD:441023"
     Region          139..165
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          175..204
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          193..364
                     /region_name="HEAT"
                     /note="HEAT repeat [General function prediction only];
                     COG1413"
                     /db_xref="CDD:441023"
     Region          216..246
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          257..281
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Site            order(273..274,277,280..281,312..313,316,319..320,323,
                     355..356,359,362..363,366,394..395,398,401..402,433..434,
                     437,440..441)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          295..323
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          337..367
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          376..402
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          378..478
                     /region_name="HEAT_2"
                     /note="HEAT repeats; pfam13646"
                     /db_xref="CDD:433376"
     Region          413..442
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          454..480
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          491..520
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          530..556
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          571..597
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     CDS             1..661
                     /gene="PPP2R1B"
                     /gene_synonym="PP2A-Abeta; PR65B"
                     /coded_by="XM_054369242.1:29..2014"
                     /db_xref="GeneID:5519"
                     /db_xref="HGNC:HGNC:9303"
                     /db_xref="MIM:603113"
ORIGIN      
        1 magaselgtg pgaaggdgdd slypiavlid elrnedvqlr lnsikklsti alalgvertr
       61 sellpfltdt iydedevlla laeqlgnftg lvggpdfahc llpplenlat veetvvrdka
      121 veslrqisqe htpvaleayf vplvkrlasg dwftsrtsac glfsvcypra snavkaeirq
      181 qfrslcsddt pmvrraaask lgefakvlel dsvkseivpl ftslasdeqd svrllaveac
      241 vsiaqllsqd dletlvmptl rqaaedkswr vrymvadrfs elqkamgpki tlndlipafq
      301 nllkdceaev raaaahkvke lgenlpiedr etiimnqilp yikelvsdtn qhvksalasv
      361 imglstilgk entiehllpl flaqlkdecp dvrlniisnl dcvnevigir qlsqsllpai
      421 velaedakwr vrlaiieymp llagqlgvef fdeklnslcm awlvdhvyai reaatnnlmk
      481 lvqkfgtewa qntivpkvlv mandpnylhr mttlfcinal seacgqeitt kqmlpivlkm
      541 agdqvanvrf nvakslqkig pildtnalqg evkpvlqklg qdedmdvkyf aqeaisvvaq
      601 rlrklefpvk dsgepsvpra dknhfprptv pgedmgkdka aqealgcvfr dpeihtiiaa
      661 l
//
LOCUS       XP_054225218             640 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A
            beta isoform isoform X2 [Homo sapiens].
ACCESSION   XP_054225218
VERSION     XP_054225218.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369243.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..640
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..640
                     /product="serine/threonine-protein phosphatase 2A 65 kDa
                     regulatory subunit A beta isoform isoform X2"
                     /calculated_mol_wt=70457
     Region          25..49
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Site            order(41..42,45,48..49,79..80,83,86..87,90,118..119,122,
                     125..126,129,157..158,161,164..165,195..196,199,202..203)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          63..90
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          100..130
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          102..239
                     /region_name="HEAT"
                     /note="HEAT repeat [General function prediction only];
                     COG1413"
                     /db_xref="CDD:441023"
     Region          139..165
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          175..204
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          193..364
                     /region_name="HEAT"
                     /note="HEAT repeat [General function prediction only];
                     COG1413"
                     /db_xref="CDD:441023"
     Region          216..246
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          257..281
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Site            order(273..274,277,280..281,312..313,316,319..320,323,
                     355..356,359,362..363,366,394..395,398,401..402,433..434,
                     437,440..441)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          295..323
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          337..367
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          376..402
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          378..478
                     /region_name="HEAT_2"
                     /note="HEAT repeats; pfam13646"
                     /db_xref="CDD:433376"
     Region          413..442
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          454..480
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          491..520
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          530..556
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          571..597
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     CDS             1..640
                     /gene="PPP2R1B"
                     /gene_synonym="PP2A-Abeta; PR65B"
                     /coded_by="XM_054369243.1:29..1951"
                     /db_xref="GeneID:5519"
                     /db_xref="HGNC:HGNC:9303"
                     /db_xref="MIM:603113"
ORIGIN      
        1 magaselgtg pgaaggdgdd slypiavlid elrnedvqlr lnsikklsti alalgvertr
       61 sellpfltdt iydedevlla laeqlgnftg lvggpdfahc llpplenlat veetvvrdka
      121 veslrqisqe htpvaleayf vplvkrlasg dwftsrtsac glfsvcypra snavkaeirq
      181 qfrslcsddt pmvrraaask lgefakvlel dsvkseivpl ftslasdeqd svrllaveac
      241 vsiaqllsqd dletlvmptl rqaaedkswr vrymvadrfs elqkamgpki tlndlipafq
      301 nllkdceaev raaaahkvke lgenlpiedr etiimnqilp yikelvsdtn qhvksalasv
      361 imglstilgk entiehllpl flaqlkdecp dvrlniisnl dcvnevigir qlsqsllpai
      421 velaedakwr vrlaiieymp llagqlgvef fdeklnslcm awlvdhvyai reaatnnlmk
      481 lvqkfgtewa qntivpkvlv mandpnylhr mttlfcinal seacgqeitt kqmlpivlkm
      541 agdqvanvrf nvakslqkig pildtnalqg evkpvlqklg qdedmdvkyf aqeaisvvaq
      601 rlrklefpvk dsgepsvpra dknhfprptv pgedmgkesg
//
LOCUS       XP_054225219             640 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A
            beta isoform isoform X2 [Homo sapiens].
ACCESSION   XP_054225219
VERSION     XP_054225219.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369244.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..640
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..640
                     /product="serine/threonine-protein phosphatase 2A 65 kDa
                     regulatory subunit A beta isoform isoform X2"
                     /calculated_mol_wt=70457
     Region          25..49
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Site            order(41..42,45,48..49,79..80,83,86..87,90,118..119,122,
                     125..126,129,157..158,161,164..165,195..196,199,202..203)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          63..90
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          100..130
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          102..239
                     /region_name="HEAT"
                     /note="HEAT repeat [General function prediction only];
                     COG1413"
                     /db_xref="CDD:441023"
     Region          139..165
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          175..204
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          193..364
                     /region_name="HEAT"
                     /note="HEAT repeat [General function prediction only];
                     COG1413"
                     /db_xref="CDD:441023"
     Region          216..246
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          257..281
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Site            order(273..274,277,280..281,312..313,316,319..320,323,
                     355..356,359,362..363,366,394..395,398,401..402,433..434,
                     437,440..441)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          295..323
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          337..367
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          376..402
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          378..478
                     /region_name="HEAT_2"
                     /note="HEAT repeats; pfam13646"
                     /db_xref="CDD:433376"
     Region          413..442
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          454..480
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          491..520
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          530..556
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          571..597
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     CDS             1..640
                     /gene="PPP2R1B"
                     /gene_synonym="PP2A-Abeta; PR65B"
                     /coded_by="XM_054369244.1:29..1951"
                     /db_xref="GeneID:5519"
                     /db_xref="HGNC:HGNC:9303"
                     /db_xref="MIM:603113"
ORIGIN      
        1 magaselgtg pgaaggdgdd slypiavlid elrnedvqlr lnsikklsti alalgvertr
       61 sellpfltdt iydedevlla laeqlgnftg lvggpdfahc llpplenlat veetvvrdka
      121 veslrqisqe htpvaleayf vplvkrlasg dwftsrtsac glfsvcypra snavkaeirq
      181 qfrslcsddt pmvrraaask lgefakvlel dsvkseivpl ftslasdeqd svrllaveac
      241 vsiaqllsqd dletlvmptl rqaaedkswr vrymvadrfs elqkamgpki tlndlipafq
      301 nllkdceaev raaaahkvke lgenlpiedr etiimnqilp yikelvsdtn qhvksalasv
      361 imglstilgk entiehllpl flaqlkdecp dvrlniisnl dcvnevigir qlsqsllpai
      421 velaedakwr vrlaiieymp llagqlgvef fdeklnslcm awlvdhvyai reaatnnlmk
      481 lvqkfgtewa qntivpkvlv mandpnylhr mttlfcinal seacgqeitt kqmlpivlkm
      541 agdqvanvrf nvakslqkig pildtnalqg evkpvlqklg qdedmdvkyf aqeaisvvaq
      601 rlrklefpvk dsgepsvpra dknhfprptv pgedmgkesg
//
LOCUS       XP_054225220             640 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A
            beta isoform isoform X2 [Homo sapiens].
ACCESSION   XP_054225220
VERSION     XP_054225220.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369245.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..640
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..640
                     /product="serine/threonine-protein phosphatase 2A 65 kDa
                     regulatory subunit A beta isoform isoform X2"
                     /calculated_mol_wt=70457
     Region          25..49
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Site            order(41..42,45,48..49,79..80,83,86..87,90,118..119,122,
                     125..126,129,157..158,161,164..165,195..196,199,202..203)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          63..90
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          100..130
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          102..239
                     /region_name="HEAT"
                     /note="HEAT repeat [General function prediction only];
                     COG1413"
                     /db_xref="CDD:441023"
     Region          139..165
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          175..204
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          193..364
                     /region_name="HEAT"
                     /note="HEAT repeat [General function prediction only];
                     COG1413"
                     /db_xref="CDD:441023"
     Region          216..246
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          257..281
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Site            order(273..274,277,280..281,312..313,316,319..320,323,
                     355..356,359,362..363,366,394..395,398,401..402,433..434,
                     437,440..441)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          295..323
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          337..367
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          376..402
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          378..478
                     /region_name="HEAT_2"
                     /note="HEAT repeats; pfam13646"
                     /db_xref="CDD:433376"
     Region          413..442
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          454..480
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          491..520
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          530..556
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          571..597
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     CDS             1..640
                     /gene="PPP2R1B"
                     /gene_synonym="PP2A-Abeta; PR65B"
                     /coded_by="XM_054369245.1:29..1951"
                     /db_xref="GeneID:5519"
                     /db_xref="HGNC:HGNC:9303"
                     /db_xref="MIM:603113"
ORIGIN      
        1 magaselgtg pgaaggdgdd slypiavlid elrnedvqlr lnsikklsti alalgvertr
       61 sellpfltdt iydedevlla laeqlgnftg lvggpdfahc llpplenlat veetvvrdka
      121 veslrqisqe htpvaleayf vplvkrlasg dwftsrtsac glfsvcypra snavkaeirq
      181 qfrslcsddt pmvrraaask lgefakvlel dsvkseivpl ftslasdeqd svrllaveac
      241 vsiaqllsqd dletlvmptl rqaaedkswr vrymvadrfs elqkamgpki tlndlipafq
      301 nllkdceaev raaaahkvke lgenlpiedr etiimnqilp yikelvsdtn qhvksalasv
      361 imglstilgk entiehllpl flaqlkdecp dvrlniisnl dcvnevigir qlsqsllpai
      421 velaedakwr vrlaiieymp llagqlgvef fdeklnslcm awlvdhvyai reaatnnlmk
      481 lvqkfgtewa qntivpkvlv mandpnylhr mttlfcinal seacgqeitt kqmlpivlkm
      541 agdqvanvrf nvakslqkig pildtnalqg evkpvlqklg qdedmdvkyf aqeaisvvaq
      601 rlrklefpvk dsgepsvpra dknhfprptv pgedmgkesg
//
LOCUS       XP_054225221             622 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A
            beta isoform isoform X3 [Homo sapiens].
ACCESSION   XP_054225221
VERSION     XP_054225221.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369246.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..622
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..622
                     /product="serine/threonine-protein phosphatase 2A 65 kDa
                     regulatory subunit A beta isoform isoform X3"
                     /calculated_mol_wt=68554
     Region          25..49
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Site            order(41..42,45,48..49,79..80,83,86..87,90,118..119,122,
                     125..126,129,157..158,161,164..165)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          63..90
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          100..130
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          116..276
                     /region_name="HEAT"
                     /note="HEAT repeat [General function prediction only];
                     COG1413"
                     /db_xref="CDD:441023"
     Region          139..165
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          217..245
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          257..281
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Site            order(273..274,277,280..281,312..313,353,356..357,360,
                     388..389,392,395..396,399,427..428,431,434..435,466..467,
                     470,473..474)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          295..360
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          295..325
                     /region_name="HEAT"
                     /note="HEAT repeat; pfam02985"
                     /db_xref="CDD:460773"
     Region          370..400
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          409..435
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          446..475
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          485..511
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          524..553
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     CDS             1..622
                     /gene="PPP2R1B"
                     /gene_synonym="PP2A-Abeta; PR65B"
                     /coded_by="XM_054369246.1:29..1897"
                     /db_xref="GeneID:5519"
                     /db_xref="HGNC:HGNC:9303"
                     /db_xref="MIM:603113"
ORIGIN      
        1 magaselgtg pgaaggdgdd slypiavlid elrnedvqlr lnsikklsti alalgvertr
       61 sellpfltdt iydedevlla laeqlgnftg lvggpdfahc llpplenlat veetvvrdka
      121 veslrqisqe htpvaleayf vplvkrlasg dwftsrtsac glfsvcypra snavkaeirq
      181 qfrslcsddt pmvrraaask lgefakvlel dsvkseivpl ftslasdeqd svrllaveac
      241 vsiaqllsqd dletlvmptl rqaaedkswr vrymvadrfs elqkamgpki tlndlipafq
      301 nllkdceaev raaaahkvke lgenlpiedr etiimnqilp yikcpdvrln iisnldcvne
      361 vigirqlsqs llpaivelae dakwrvrlai ieympllagq lgveffdekl nslcmawlvd
      421 hvyaireaat nnlmklvqkf gtewaqntiv pkvlvmandp nylhrmttlf cinalseacg
      481 qeittkqmlp ivlkmagdqv anvrfnvaks lqkigpildt nalqgevkpv lqklgqdedm
      541 dvkyfaqeai svvaqrlrkl efpvkdsgep svpradknhf prptvpgedm gkgpvyqlrg
      601 dtrdtlaqlg iaelvhfsqs td
//
LOCUS       XP_054225222             595 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A
            beta isoform isoform X4 [Homo sapiens].
ACCESSION   XP_054225222
VERSION     XP_054225222.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369247.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..595
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..595
                     /product="serine/threonine-protein phosphatase 2A 65 kDa
                     regulatory subunit A beta isoform isoform X4"
                     /calculated_mol_wt=65557
     Region          25..49
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Site            order(41..42,45,48..49,79..80,83,86..87,90,118..119,122,
                     125..126,129,157..158,161,164..165)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          63..90
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          100..130
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          116..276
                     /region_name="HEAT"
                     /note="HEAT repeat [General function prediction only];
                     COG1413"
                     /db_xref="CDD:441023"
     Region          139..165
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          217..245
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          257..281
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Site            order(273..274,277,280..281,312..313,353,356..357,360,
                     388..389,392,395..396,399,427..428,431,434..435,466..467,
                     470,473..474)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          295..360
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          295..325
                     /region_name="HEAT"
                     /note="HEAT repeat; pfam02985"
                     /db_xref="CDD:460773"
     Region          370..400
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          409..435
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          446..475
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          485..511
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          524..553
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     CDS             1..595
                     /gene="PPP2R1B"
                     /gene_synonym="PP2A-Abeta; PR65B"
                     /coded_by="XM_054369247.1:29..1816"
                     /db_xref="GeneID:5519"
                     /db_xref="HGNC:HGNC:9303"
                     /db_xref="MIM:603113"
ORIGIN      
        1 magaselgtg pgaaggdgdd slypiavlid elrnedvqlr lnsikklsti alalgvertr
       61 sellpfltdt iydedevlla laeqlgnftg lvggpdfahc llpplenlat veetvvrdka
      121 veslrqisqe htpvaleayf vplvkrlasg dwftsrtsac glfsvcypra snavkaeirq
      181 qfrslcsddt pmvrraaask lgefakvlel dsvkseivpl ftslasdeqd svrllaveac
      241 vsiaqllsqd dletlvmptl rqaaedkswr vrymvadrfs elqkamgpki tlndlipafq
      301 nllkdceaev raaaahkvke lgenlpiedr etiimnqilp yikcpdvrln iisnldcvne
      361 vigirqlsqs llpaivelae dakwrvrlai ieympllagq lgveffdekl nslcmawlvd
      421 hvyaireaat nnlmklvqkf gtewaqntiv pkvlvmandp nylhrmttlf cinalseacg
      481 qeittkqmlp ivlkmagdqv anvrfnvaks lqkigpildt nalqgevkpv lqklgqdedm
      541 dvkyfaqeai svvaqrlrkl efpvkdsgep svpradknhf prptvpgedm gkesg
//
LOCUS       XP_054225223             688 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A
            beta isoform isoform X5 [Homo sapiens].
ACCESSION   XP_054225223
VERSION     XP_054225223.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369248.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..688
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..688
                     /product="serine/threonine-protein phosphatase 2A 65 kDa
                     regulatory subunit A beta isoform isoform X5"
                     /calculated_mol_wt=76255
     Region          25..152
                     /region_name="HEAT"
                     /note="HEAT repeat [General function prediction only];
                     COG1413"
                     /db_xref="CDD:441023"
     Region          25..49
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Site            order(41..42,45,48..49,79..80,83,86..87,90,118..119,122,
                     125..126,129,157..158,161,164..165,195..196,199,202..203)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          63..90
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          100..130
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          102..239
                     /region_name="HEAT"
                     /note="HEAT repeat [General function prediction only];
                     COG1413"
                     /db_xref="CDD:441023"
     Region          139..165
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          175..204
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          193..364
                     /region_name="HEAT"
                     /note="HEAT repeat [General function prediction only];
                     COG1413"
                     /db_xref="CDD:441023"
     Region          216..246
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          257..281
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Site            order(273..274,277,280..281,312..313,316,319..320,323,
                     355..356,359,362..363,366,394..395,398,401..402,433..434,
                     437,440..441)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          295..323
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          337..367
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          376..402
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          378..478
                     /region_name="HEAT_2"
                     /note="HEAT repeats; pfam13646"
                     /db_xref="CDD:433376"
     Region          413..442
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          454..480
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          491..520
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          530..556
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          571..597
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     CDS             1..688
                     /gene="PPP2R1B"
                     /gene_synonym="PP2A-Abeta; PR65B"
                     /coded_by="XM_054369248.1:29..2095"
                     /db_xref="GeneID:5519"
                     /db_xref="HGNC:HGNC:9303"
                     /db_xref="MIM:603113"
ORIGIN      
        1 magaselgtg pgaaggdgdd slypiavlid elrnedvqlr lnsikklsti alalgvertr
       61 sellpfltdt iydedevlla laeqlgnftg lvggpdfahc llpplenlat veetvvrdka
      121 veslrqisqe htpvaleayf vplvkrlasg dwftsrtsac glfsvcypra snavkaeirq
      181 qfrslcsddt pmvrraaask lgefakvlel dsvkseivpl ftslasdeqd svrllaveac
      241 vsiaqllsqd dletlvmptl rqaaedkswr vrymvadrfs elqkamgpki tlndlipafq
      301 nllkdceaev raaaahkvke lgenlpiedr etiimnqilp yikelvsdtn qhvksalasv
      361 imglstilgk entiehllpl flaqlkdecp dvrlniisnl dcvnevigir qlsqsllpai
      421 velaedakwr vrlaiieymp llagqlgvef fdeklnslcm awlvdhvyai reaatnnlmk
      481 lvqkfgtewa qntivpkvlv mandpnylhr mttlfcinal seacgqeitt kqmlpivlkm
      541 agdqvanvrf nvakslqkig pildtnalqg evkpvlqklg qdedmdvkyf aqeaisvvaq
      601 rlrklefpvk dsgepsvpra dknhfprptv pgedmgkfsp fmfrhketew lgwlprrqle
      661 aaqfrslsva gqpwhrcqpl ftgtetvk
//
LOCUS       XP_054225224             293 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein NKAPD1 isoform X1 [Homo sapiens].
ACCESSION   XP_054225224
VERSION     XP_054225224.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369249.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..293
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..293
                     /product="uncharacterized protein NKAPD1 isoform X1"
                     /calculated_mol_wt=34066
     Region          93..>147
                     /region_name="NKAP"
                     /note="NF-kappa-B-activating protein; pfam15692"
                     /db_xref="CDD:464805"
     CDS             1..293
                     /gene="NKAPD1"
                     /gene_synonym="C11orf57"
                     /coded_by="XM_054369249.1:99..980"
                     /db_xref="GeneID:55216"
                     /db_xref="HGNC:HGNC:25569"
ORIGIN      
        1 msriplgkvl lrnvirhtda hnkiqeesdm wkirelekqm edayrgtkrk mlpssssrmr
       61 sdgfdeesqr yywrpkneis gtleddflka kswnkkfydy eanmpdrwgh sgykelypee
      121 fetdssdqqd itngkktspq vkssthesrk hkkskkshkk kqkkrshkkq kkskkeatdi
      181 tadsssefse etgasgtrkg kqphkrkkks rkkslkkpal fleaesntsh sddsasssse
      241 eseerdtkkt krkkrekkah tsvanneiqe rtnkrtnwkv atdersaess edd
//
LOCUS       XP_054225225             292 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein NKAPD1 isoform X2 [Homo sapiens].
ACCESSION   XP_054225225
VERSION     XP_054225225.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369250.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..292
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..292
                     /product="uncharacterized protein NKAPD1 isoform X2"
                     /calculated_mol_wt=33979
     Region          93..>146
                     /region_name="NKAP"
                     /note="NF-kappa-B-activating protein; pfam15692"
                     /db_xref="CDD:464805"
     CDS             1..292
                     /gene="NKAPD1"
                     /gene_synonym="C11orf57"
                     /coded_by="XM_054369250.1:99..977"
                     /db_xref="GeneID:55216"
                     /db_xref="HGNC:HGNC:25569"
ORIGIN      
        1 msriplgkvl lrnvirhtda hnkiqeesdm wkirelekqm edayrgtkrk mlpssssrmr
       61 sdgfdeesqr yywrpkneis gtleddflka kswnkkfydy eanmpdrwgh sgykelypee
      121 fetdsdqqdi tngkktspqv kssthesrkh kkskkshkkk qkkrshkkqk kskkeatdit
      181 adsssefsee tgasgtrkgk qphkrkkksr kkslkkpalf leaesntshs ddsassssee
      241 seerdtkktk rkkrekkaht svanneiqer tnkrtnwkva tdersaesse dd
//
LOCUS       XP_054225226             497 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
            beta isoform isoform X1 [Homo sapiens].
ACCESSION   XP_054225226
VERSION     XP_054225226.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369251.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..497
                     /product="serine/threonine-protein phosphatase 2A 56 kDa
                     regulatory subunit beta isoform isoform X1"
                     /calculated_mol_wt=57262
     Region          69..467
                     /region_name="B56"
                     /note="Protein phosphatase 2A regulatory B subunit (B56
                     family); pfam01603"
                     /db_xref="CDD:460264"
     CDS             1..497
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; B56beta; PR61B"
                     /coded_by="XM_054369251.1:2811..4304"
                     /db_xref="GeneID:5526"
                     /db_xref="HGNC:HGNC:9310"
                     /db_xref="MIM:601644"
ORIGIN      
        1 metklppast ptspsspgls pvpppdkvdg fsrrslrrar prrshsssqf ryqsnqqelt
       61 plpllkdvpa selhellsrk laqcgvmfdf ldcvadlkgk evkraalnel vecvgstrgv
      121 liepvypdii rmisvnifrt lppsenpefd peedepnlep swphlqlvye fflrflespd
      181 fqpsvakryv dqkfvlmlle lfdsedprer eylktilhrv ygkflglray irkqcnhifl
      241 rfiyefehfn gvaelleilg siingfalpl ktehkqflvr vliplhsvks lsvfhaqlay
      301 cvvqflekda tltehvirgl lkywpktctq kevmflgeme eildviepsq fvkiqeplfk
      361 qvarcvssph fqvaeralyf wnneyilsli ednchtvlpa vfgtlyqvsk ehwnqtivsl
      421 iynvlktfme mngklfdelt asyklekqqe qqkaqerqel wqgleelrlr rlqgtqgake
      481 aplqrltpqv aasggqs
//
LOCUS       XP_054225227             468 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
            beta isoform isoform X2 [Homo sapiens].
ACCESSION   XP_054225227
VERSION     XP_054225227.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369252.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..468
                     /product="serine/threonine-protein phosphatase 2A 56 kDa
                     regulatory subunit beta isoform isoform X2"
                     /calculated_mol_wt=54335
     Region          40..438
                     /region_name="B56"
                     /note="Protein phosphatase 2A regulatory B subunit (B56
                     family); pfam01603"
                     /db_xref="CDD:460264"
     CDS             1..468
                     /gene="PPP2R5B"
                     /gene_synonym="B56B; B56beta; PR61B"
                     /coded_by="XM_054369252.1:145..1551"
                     /db_xref="GeneID:5526"
                     /db_xref="HGNC:HGNC:9310"
                     /db_xref="MIM:601644"
ORIGIN      
        1 mgdfrnshra rprrshsssq fryqsnqqel tplpllkdvp aselhellsr klaqcgvmfd
       61 fldcvadlkg kevkraalne lvecvgstrg vliepvypdi irmisvnifr tlppsenpef
      121 dpeedepnle pswphlqlvy efflrflesp dfqpsvakry vdqkfvlmll elfdsedpre
      181 reylktilhr vygkflglra yirkqcnhif lrfiyefehf ngvaelleil gsiingfalp
      241 lktehkqflv rvliplhsvk slsvfhaqla ycvvqflekd atltehvirg llkywpktct
      301 qkevmflgem eeildvieps qfvkiqeplf kqvarcvssp hfqvaeraly fwnneyilsl
      361 iednchtvlp avfgtlyqvs kehwnqtivs liynvlktfm emngklfdel tasyklekqq
      421 eqqkaqerqe lwqgleelrl rrlqgtqgak eaplqrltpq vaasggqs
//
LOCUS       XP_054225228             883 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform
            X1 [Homo sapiens].
ACCESSION   XP_054225228
VERSION     XP_054225228.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369253.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..883
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..883
                     /product="serine/threonine-protein phosphatase 6
                     regulatory subunit 3 isoform X1"
                     /calculated_mol_wt=98526
     Region          128..513
                     /region_name="SAPS"
                     /note="SIT4 phosphatase-associated protein; pfam04499"
                     /db_xref="CDD:398279"
     CDS             1..883
                     /gene="PPP6R3"
                     /gene_synonym="C11orf23; PP6R3; SAP190; SAPL; SAPLa;
                     SAPS3"
                     /coded_by="XM_054369253.1:361..3012"
                     /db_xref="GeneID:55291"
                     /db_xref="HGNC:HGNC:1173"
                     /db_xref="MIM:610879"
ORIGIN      
        1 mfwkfdlhss shidtllere dvtlkelmde edvlqeckaq nrkliefllk aecledlvsf
       61 iieeppqdmd ekirykypni scelltsdvs qmndrlgede sllmklysfl lndsplnpll
      121 asffskvlsi lisrkpeqiv dflkkkhdfv dliikhigts aimdlllrll tcieppqprq
      181 dvlnwlneek iiqrlveivh psqeedrhsn asqslceivr lsrdqmlqiq nstepdplla
      241 tlekqeiieq llsnifhkek nesaivsaiq illtlletrr ptfeghieic ppgmshsacs
      301 vnksvleair grlgsfhell leppkksvmk ttwgvldppv gntrlnvirl issllqtnts
      361 singdlmeln sigvilnmff kytwnnflht qveicialil aspfentena titdqdstgd
      421 nlllkhlfqk cqlierilea wemnekkqae ggrrhgymgh ltriancivh stdkgpnsal
      481 vqqlikdlpd evrerwetfc tsslgetnkr ntvdlvttch ihsssddeid fketgfsqds
      541 slqqafsdyq mqqmtsnfid qfgfndekfa dqddignvsf drvsdinftl ntnesgnial
      601 feacckeriq qfddggsdee diweekhiaf tpesqrrsss gstdseestd seeedgakqd
      661 lfepssante dkmevdlsep pnwsanfdvp metthgapld svgsdvwste epmptketgw
      721 asfseftssl stkdslrsns pvemetstep mdpltpsaaa lavqpeaags vameassdge
      781 edaestdkvt etvmnggmke tlsltvdakt etavfkseeg klstsqdaac kdaeecpeta
      841 eakcaaprpp ssspeqsasd acllllrtgq psapgdtsvn gpv
//
LOCUS       XP_054225229             883 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform
            X1 [Homo sapiens].
ACCESSION   XP_054225229
VERSION     XP_054225229.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369254.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..883
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..883
                     /product="serine/threonine-protein phosphatase 6
                     regulatory subunit 3 isoform X1"
                     /calculated_mol_wt=98526
     Region          128..513
                     /region_name="SAPS"
                     /note="SIT4 phosphatase-associated protein; pfam04499"
                     /db_xref="CDD:398279"
     CDS             1..883
                     /gene="PPP6R3"
                     /gene_synonym="C11orf23; PP6R3; SAP190; SAPL; SAPLa;
                     SAPS3"
                     /coded_by="XM_054369254.1:234..2885"
                     /db_xref="GeneID:55291"
                     /db_xref="HGNC:HGNC:1173"
                     /db_xref="MIM:610879"
ORIGIN      
        1 mfwkfdlhss shidtllere dvtlkelmde edvlqeckaq nrkliefllk aecledlvsf
       61 iieeppqdmd ekirykypni scelltsdvs qmndrlgede sllmklysfl lndsplnpll
      121 asffskvlsi lisrkpeqiv dflkkkhdfv dliikhigts aimdlllrll tcieppqprq
      181 dvlnwlneek iiqrlveivh psqeedrhsn asqslceivr lsrdqmlqiq nstepdplla
      241 tlekqeiieq llsnifhkek nesaivsaiq illtlletrr ptfeghieic ppgmshsacs
      301 vnksvleair grlgsfhell leppkksvmk ttwgvldppv gntrlnvirl issllqtnts
      361 singdlmeln sigvilnmff kytwnnflht qveicialil aspfentena titdqdstgd
      421 nlllkhlfqk cqlierilea wemnekkqae ggrrhgymgh ltriancivh stdkgpnsal
      481 vqqlikdlpd evrerwetfc tsslgetnkr ntvdlvttch ihsssddeid fketgfsqds
      541 slqqafsdyq mqqmtsnfid qfgfndekfa dqddignvsf drvsdinftl ntnesgnial
      601 feacckeriq qfddggsdee diweekhiaf tpesqrrsss gstdseestd seeedgakqd
      661 lfepssante dkmevdlsep pnwsanfdvp metthgapld svgsdvwste epmptketgw
      721 asfseftssl stkdslrsns pvemetstep mdpltpsaaa lavqpeaags vameassdge
      781 edaestdkvt etvmnggmke tlsltvdakt etavfkseeg klstsqdaac kdaeecpeta
      841 eakcaaprpp ssspeqsasd acllllrtgq psapgdtsvn gpv
//
LOCUS       XP_054225230             877 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform
            X2 [Homo sapiens].
ACCESSION   XP_054225230
VERSION     XP_054225230.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369255.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..877
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..877
                     /product="serine/threonine-protein phosphatase 6
                     regulatory subunit 3 isoform X2"
                     /calculated_mol_wt=97814
     Region          128..513
                     /region_name="SAPS"
                     /note="SIT4 phosphatase-associated protein; pfam04499"
                     /db_xref="CDD:398279"
     CDS             1..877
                     /gene="PPP6R3"
                     /gene_synonym="C11orf23; PP6R3; SAP190; SAPL; SAPLa;
                     SAPS3"
                     /coded_by="XM_054369255.1:361..2994"
                     /db_xref="GeneID:55291"
                     /db_xref="HGNC:HGNC:1173"
                     /db_xref="MIM:610879"
ORIGIN      
        1 mfwkfdlhss shidtllere dvtlkelmde edvlqeckaq nrkliefllk aecledlvsf
       61 iieeppqdmd ekirykypni scelltsdvs qmndrlgede sllmklysfl lndsplnpll
      121 asffskvlsi lisrkpeqiv dflkkkhdfv dliikhigts aimdlllrll tcieppqprq
      181 dvlnwlneek iiqrlveivh psqeedrhsn asqslceivr lsrdqmlqiq nstepdplla
      241 tlekqeiieq llsnifhkek nesaivsaiq illtlletrr ptfeghieic ppgmshsacs
      301 vnksvleair grlgsfhell leppkksvmk ttwgvldppv gntrlnvirl issllqtnts
      361 singdlmeln sigvilnmff kytwnnflht qveicialil aspfentena titdqdstgd
      421 nlllkhlfqk cqlierilea wemnekkqae ggrrhgymgh ltriancivh stdkgpnsal
      481 vqqlikdlpd evrerwetfc tsslgetnkr ntvdlvttch ihsssddeid fketgfsqds
      541 slqqmqqmts nfidqfgfnd ekfadqddig nvsfdrvsdi nftlntnesg nialfeacck
      601 eriqqfddgg sdeediweek hiaftpesqr rsssgstdse estdseeedg akqdlfepss
      661 antedkmevd lseppnwsan fdvpmetthg apldsvgsdv wsteepmptk etgwasfsef
      721 tsslstkdsl rsnspvemet stepmdpltp saaalavqpe aagsvameas sdgeedaest
      781 dkvtetvmng gmketlsltv daktetavfk seegklstsq daackdaeec petaeakcaa
      841 prppssspeq sasdacllll rtgqpsapgd tsvngpv
//
LOCUS       XP_054225231             877 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform
            X2 [Homo sapiens].
ACCESSION   XP_054225231
VERSION     XP_054225231.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369256.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..877
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..877
                     /product="serine/threonine-protein phosphatase 6
                     regulatory subunit 3 isoform X2"
                     /calculated_mol_wt=97814
     Region          128..513
                     /region_name="SAPS"
                     /note="SIT4 phosphatase-associated protein; pfam04499"
                     /db_xref="CDD:398279"
     CDS             1..877
                     /gene="PPP6R3"
                     /gene_synonym="C11orf23; PP6R3; SAP190; SAPL; SAPLa;
                     SAPS3"
                     /coded_by="XM_054369256.1:234..2867"
                     /db_xref="GeneID:55291"
                     /db_xref="HGNC:HGNC:1173"
                     /db_xref="MIM:610879"
ORIGIN      
        1 mfwkfdlhss shidtllere dvtlkelmde edvlqeckaq nrkliefllk aecledlvsf
       61 iieeppqdmd ekirykypni scelltsdvs qmndrlgede sllmklysfl lndsplnpll
      121 asffskvlsi lisrkpeqiv dflkkkhdfv dliikhigts aimdlllrll tcieppqprq
      181 dvlnwlneek iiqrlveivh psqeedrhsn asqslceivr lsrdqmlqiq nstepdplla
      241 tlekqeiieq llsnifhkek nesaivsaiq illtlletrr ptfeghieic ppgmshsacs
      301 vnksvleair grlgsfhell leppkksvmk ttwgvldppv gntrlnvirl issllqtnts
      361 singdlmeln sigvilnmff kytwnnflht qveicialil aspfentena titdqdstgd
      421 nlllkhlfqk cqlierilea wemnekkqae ggrrhgymgh ltriancivh stdkgpnsal
      481 vqqlikdlpd evrerwetfc tsslgetnkr ntvdlvttch ihsssddeid fketgfsqds
      541 slqqmqqmts nfidqfgfnd ekfadqddig nvsfdrvsdi nftlntnesg nialfeacck
      601 eriqqfddgg sdeediweek hiaftpesqr rsssgstdse estdseeedg akqdlfepss
      661 antedkmevd lseppnwsan fdvpmetthg apldsvgsdv wsteepmptk etgwasfsef
      721 tsslstkdsl rsnspvemet stepmdpltp saaalavqpe aagsvameas sdgeedaest
      781 dkvtetvmng gmketlsltv daktetavfk seegklstsq daackdaeec petaeakcaa
      841 prppssspeq sasdacllll rtgqpsapgd tsvngpv
//
LOCUS       XP_054225232             873 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform
            X3 [Homo sapiens].
ACCESSION   XP_054225232
VERSION     XP_054225232.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369257.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..873
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..873
                     /product="serine/threonine-protein phosphatase 6
                     regulatory subunit 3 isoform X3"
                     /calculated_mol_wt=97538
     Region          128..513
                     /region_name="SAPS"
                     /note="SIT4 phosphatase-associated protein; pfam04499"
                     /db_xref="CDD:398279"
     CDS             1..873
                     /gene="PPP6R3"
                     /gene_synonym="C11orf23; PP6R3; SAP190; SAPL; SAPLa;
                     SAPS3"
                     /coded_by="XM_054369257.1:557..3178"
                     /db_xref="GeneID:55291"
                     /db_xref="HGNC:HGNC:1173"
                     /db_xref="MIM:610879"
ORIGIN      
        1 mfwkfdlhss shidtllere dvtlkelmde edvlqeckaq nrkliefllk aecledlvsf
       61 iieeppqdmd ekirykypni scelltsdvs qmndrlgede sllmklysfl lndsplnpll
      121 asffskvlsi lisrkpeqiv dflkkkhdfv dliikhigts aimdlllrll tcieppqprq
      181 dvlnwlneek iiqrlveivh psqeedrhsn asqslceivr lsrdqmlqiq nstepdplla
      241 tlekqeiieq llsnifhkek nesaivsaiq illtlletrr ptfeghieic ppgmshsacs
      301 vnksvleair grlgsfhell leppkksvmk ttwgvldppv gntrlnvirl issllqtnts
      361 singdlmeln sigvilnmff kytwnnflht qveicialil aspfentena titdqdstgd
      421 nlllkhlfqk cqlierilea wemnekkqae ggrrhgymgh ltriancivh stdkgpnsal
      481 vqqlikdlpd evrerwetfc tsslgetnkr ntvdlvttch ihsssddeid fketgfsqds
      541 slqqafsdyq mqqmtsnfid qfgfndekfa dqddignvsf drvsdinftl ntnesgnial
      601 feacckeriq qfddggsdee diweekhiaf tpesqrrsss gstdseestd seeedgakqd
      661 lfepssante dkmevdlsep pnwsanfdvp metthgapld svgsdvwste epmptketgw
      721 asfseftssl stkdslrsns pvemetstep mdpltpsaaa lavqpeaags vameassdge
      781 edaestdkvt etvmnggmke tlsltvdakt etavfkseeg klstsqdaac kdaeecpeta
      841 eakcaaprpp ssspeqrtgq psapgdtsvn gpv
//
LOCUS       XP_054225233             873 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform
            X3 [Homo sapiens].
ACCESSION   XP_054225233
VERSION     XP_054225233.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369258.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..873
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..873
                     /product="serine/threonine-protein phosphatase 6
                     regulatory subunit 3 isoform X3"
                     /calculated_mol_wt=97538
     Region          128..513
                     /region_name="SAPS"
                     /note="SIT4 phosphatase-associated protein; pfam04499"
                     /db_xref="CDD:398279"
     CDS             1..873
                     /gene="PPP6R3"
                     /gene_synonym="C11orf23; PP6R3; SAP190; SAPL; SAPLa;
                     SAPS3"
                     /coded_by="XM_054369258.1:535..3156"
                     /db_xref="GeneID:55291"
                     /db_xref="HGNC:HGNC:1173"
                     /db_xref="MIM:610879"
ORIGIN      
        1 mfwkfdlhss shidtllere dvtlkelmde edvlqeckaq nrkliefllk aecledlvsf
       61 iieeppqdmd ekirykypni scelltsdvs qmndrlgede sllmklysfl lndsplnpll
      121 asffskvlsi lisrkpeqiv dflkkkhdfv dliikhigts aimdlllrll tcieppqprq
      181 dvlnwlneek iiqrlveivh psqeedrhsn asqslceivr lsrdqmlqiq nstepdplla
      241 tlekqeiieq llsnifhkek nesaivsaiq illtlletrr ptfeghieic ppgmshsacs
      301 vnksvleair grlgsfhell leppkksvmk ttwgvldppv gntrlnvirl issllqtnts
      361 singdlmeln sigvilnmff kytwnnflht qveicialil aspfentena titdqdstgd
      421 nlllkhlfqk cqlierilea wemnekkqae ggrrhgymgh ltriancivh stdkgpnsal
      481 vqqlikdlpd evrerwetfc tsslgetnkr ntvdlvttch ihsssddeid fketgfsqds
      541 slqqafsdyq mqqmtsnfid qfgfndekfa dqddignvsf drvsdinftl ntnesgnial
      601 feacckeriq qfddggsdee diweekhiaf tpesqrrsss gstdseestd seeedgakqd
      661 lfepssante dkmevdlsep pnwsanfdvp metthgapld svgsdvwste epmptketgw
      721 asfseftssl stkdslrsns pvemetstep mdpltpsaaa lavqpeaags vameassdge
      781 edaestdkvt etvmnggmke tlsltvdakt etavfkseeg klstsqdaac kdaeecpeta
      841 eakcaaprpp ssspeqrtgq psapgdtsvn gpv
//
LOCUS       XP_054225234             867 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform
            X4 [Homo sapiens].
ACCESSION   XP_054225234
VERSION     XP_054225234.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369259.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..867
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..867
                     /product="serine/threonine-protein phosphatase 6
                     regulatory subunit 3 isoform X4"
                     /calculated_mol_wt=96827
     Region          128..513
                     /region_name="SAPS"
                     /note="SIT4 phosphatase-associated protein; pfam04499"
                     /db_xref="CDD:398279"
     CDS             1..867
                     /gene="PPP6R3"
                     /gene_synonym="C11orf23; PP6R3; SAP190; SAPL; SAPLa;
                     SAPS3"
                     /coded_by="XM_054369259.1:361..2964"
                     /db_xref="GeneID:55291"
                     /db_xref="HGNC:HGNC:1173"
                     /db_xref="MIM:610879"
ORIGIN      
        1 mfwkfdlhss shidtllere dvtlkelmde edvlqeckaq nrkliefllk aecledlvsf
       61 iieeppqdmd ekirykypni scelltsdvs qmndrlgede sllmklysfl lndsplnpll
      121 asffskvlsi lisrkpeqiv dflkkkhdfv dliikhigts aimdlllrll tcieppqprq
      181 dvlnwlneek iiqrlveivh psqeedrhsn asqslceivr lsrdqmlqiq nstepdplla
      241 tlekqeiieq llsnifhkek nesaivsaiq illtlletrr ptfeghieic ppgmshsacs
      301 vnksvleair grlgsfhell leppkksvmk ttwgvldppv gntrlnvirl issllqtnts
      361 singdlmeln sigvilnmff kytwnnflht qveicialil aspfentena titdqdstgd
      421 nlllkhlfqk cqlierilea wemnekkqae ggrrhgymgh ltriancivh stdkgpnsal
      481 vqqlikdlpd evrerwetfc tsslgetnkr ntvdlvttch ihsssddeid fketgfsqds
      541 slqqmqqmts nfidqfgfnd ekfadqddig nvsfdrvsdi nftlntnesg nialfeacck
      601 eriqqfddgg sdeediweek hiaftpesqr rsssgstdse estdseeedg akqdlfepss
      661 antedkmevd lseppnwsan fdvpmetthg apldsvgsdv wsteepmptk etgwasfsef
      721 tsslstkdsl rsnspvemet stepmdpltp saaalavqpe aagsvameas sdgeedaest
      781 dkvtetvmng gmketlsltv daktetavfk seegklstsq daackdaeec petaeakcaa
      841 prppssspeq rtgqpsapgd tsvngpv
//
LOCUS       XP_054225235             867 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform
            X4 [Homo sapiens].
ACCESSION   XP_054225235
VERSION     XP_054225235.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369260.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..867
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..867
                     /product="serine/threonine-protein phosphatase 6
                     regulatory subunit 3 isoform X4"
                     /calculated_mol_wt=96827
     Region          128..513
                     /region_name="SAPS"
                     /note="SIT4 phosphatase-associated protein; pfam04499"
                     /db_xref="CDD:398279"
     CDS             1..867
                     /gene="PPP6R3"
                     /gene_synonym="C11orf23; PP6R3; SAP190; SAPL; SAPLa;
                     SAPS3"
                     /coded_by="XM_054369260.1:557..3160"
                     /db_xref="GeneID:55291"
                     /db_xref="HGNC:HGNC:1173"
                     /db_xref="MIM:610879"
ORIGIN      
        1 mfwkfdlhss shidtllere dvtlkelmde edvlqeckaq nrkliefllk aecledlvsf
       61 iieeppqdmd ekirykypni scelltsdvs qmndrlgede sllmklysfl lndsplnpll
      121 asffskvlsi lisrkpeqiv dflkkkhdfv dliikhigts aimdlllrll tcieppqprq
      181 dvlnwlneek iiqrlveivh psqeedrhsn asqslceivr lsrdqmlqiq nstepdplla
      241 tlekqeiieq llsnifhkek nesaivsaiq illtlletrr ptfeghieic ppgmshsacs
      301 vnksvleair grlgsfhell leppkksvmk ttwgvldppv gntrlnvirl issllqtnts
      361 singdlmeln sigvilnmff kytwnnflht qveicialil aspfentena titdqdstgd
      421 nlllkhlfqk cqlierilea wemnekkqae ggrrhgymgh ltriancivh stdkgpnsal
      481 vqqlikdlpd evrerwetfc tsslgetnkr ntvdlvttch ihsssddeid fketgfsqds
      541 slqqmqqmts nfidqfgfnd ekfadqddig nvsfdrvsdi nftlntnesg nialfeacck
      601 eriqqfddgg sdeediweek hiaftpesqr rsssgstdse estdseeedg akqdlfepss
      661 antedkmevd lseppnwsan fdvpmetthg apldsvgsdv wsteepmptk etgwasfsef
      721 tsslstkdsl rsnspvemet stepmdpltp saaalavqpe aagsvameas sdgeedaest
      781 dkvtetvmng gmketlsltv daktetavfk seegklstsq daackdaeec petaeakcaa
      841 prppssspeq rtgqpsapgd tsvngpv
//
LOCUS       XP_054225236             867 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform
            X4 [Homo sapiens].
ACCESSION   XP_054225236
VERSION     XP_054225236.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369261.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..867
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..867
                     /product="serine/threonine-protein phosphatase 6
                     regulatory subunit 3 isoform X4"
                     /calculated_mol_wt=96827
     Region          128..513
                     /region_name="SAPS"
                     /note="SIT4 phosphatase-associated protein; pfam04499"
                     /db_xref="CDD:398279"
     CDS             1..867
                     /gene="PPP6R3"
                     /gene_synonym="C11orf23; PP6R3; SAP190; SAPL; SAPLa;
                     SAPS3"
                     /coded_by="XM_054369261.1:535..3138"
                     /db_xref="GeneID:55291"
                     /db_xref="HGNC:HGNC:1173"
                     /db_xref="MIM:610879"
ORIGIN      
        1 mfwkfdlhss shidtllere dvtlkelmde edvlqeckaq nrkliefllk aecledlvsf
       61 iieeppqdmd ekirykypni scelltsdvs qmndrlgede sllmklysfl lndsplnpll
      121 asffskvlsi lisrkpeqiv dflkkkhdfv dliikhigts aimdlllrll tcieppqprq
      181 dvlnwlneek iiqrlveivh psqeedrhsn asqslceivr lsrdqmlqiq nstepdplla
      241 tlekqeiieq llsnifhkek nesaivsaiq illtlletrr ptfeghieic ppgmshsacs
      301 vnksvleair grlgsfhell leppkksvmk ttwgvldppv gntrlnvirl issllqtnts
      361 singdlmeln sigvilnmff kytwnnflht qveicialil aspfentena titdqdstgd
      421 nlllkhlfqk cqlierilea wemnekkqae ggrrhgymgh ltriancivh stdkgpnsal
      481 vqqlikdlpd evrerwetfc tsslgetnkr ntvdlvttch ihsssddeid fketgfsqds
      541 slqqmqqmts nfidqfgfnd ekfadqddig nvsfdrvsdi nftlntnesg nialfeacck
      601 eriqqfddgg sdeediweek hiaftpesqr rsssgstdse estdseeedg akqdlfepss
      661 antedkmevd lseppnwsan fdvpmetthg apldsvgsdv wsteepmptk etgwasfsef
      721 tsslstkdsl rsnspvemet stepmdpltp saaalavqpe aagsvameas sdgeedaest
      781 dkvtetvmng gmketlsltv daktetavfk seegklstsq daackdaeec petaeakcaa
      841 prppssspeq rtgqpsapgd tsvngpv
//
LOCUS       XP_054225237             867 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform
            X4 [Homo sapiens].
ACCESSION   XP_054225237
VERSION     XP_054225237.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369262.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..867
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..867
                     /product="serine/threonine-protein phosphatase 6
                     regulatory subunit 3 isoform X4"
                     /calculated_mol_wt=96827
     Region          128..513
                     /region_name="SAPS"
                     /note="SIT4 phosphatase-associated protein; pfam04499"
                     /db_xref="CDD:398279"
     CDS             1..867
                     /gene="PPP6R3"
                     /gene_synonym="C11orf23; PP6R3; SAP190; SAPL; SAPLa;
                     SAPS3"
                     /coded_by="XM_054369262.1:339..2942"
                     /db_xref="GeneID:55291"
                     /db_xref="HGNC:HGNC:1173"
                     /db_xref="MIM:610879"
ORIGIN      
        1 mfwkfdlhss shidtllere dvtlkelmde edvlqeckaq nrkliefllk aecledlvsf
       61 iieeppqdmd ekirykypni scelltsdvs qmndrlgede sllmklysfl lndsplnpll
      121 asffskvlsi lisrkpeqiv dflkkkhdfv dliikhigts aimdlllrll tcieppqprq
      181 dvlnwlneek iiqrlveivh psqeedrhsn asqslceivr lsrdqmlqiq nstepdplla
      241 tlekqeiieq llsnifhkek nesaivsaiq illtlletrr ptfeghieic ppgmshsacs
      301 vnksvleair grlgsfhell leppkksvmk ttwgvldppv gntrlnvirl issllqtnts
      361 singdlmeln sigvilnmff kytwnnflht qveicialil aspfentena titdqdstgd
      421 nlllkhlfqk cqlierilea wemnekkqae ggrrhgymgh ltriancivh stdkgpnsal
      481 vqqlikdlpd evrerwetfc tsslgetnkr ntvdlvttch ihsssddeid fketgfsqds
      541 slqqmqqmts nfidqfgfnd ekfadqddig nvsfdrvsdi nftlntnesg nialfeacck
      601 eriqqfddgg sdeediweek hiaftpesqr rsssgstdse estdseeedg akqdlfepss
      661 antedkmevd lseppnwsan fdvpmetthg apldsvgsdv wsteepmptk etgwasfsef
      721 tsslstkdsl rsnspvemet stepmdpltp saaalavqpe aagsvameas sdgeedaest
      781 dkvtetvmng gmketlsltv daktetavfk seegklstsq daackdaeec petaeakcaa
      841 prppssspeq rtgqpsapgd tsvngpv
//
LOCUS       XP_054225238             866 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform
            X5 [Homo sapiens].
ACCESSION   XP_054225238
VERSION     XP_054225238.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369263.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..866
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..866
                     /product="serine/threonine-protein phosphatase 6
                     regulatory subunit 3 isoform X5"
                     /calculated_mol_wt=96489
     Region          128..513
                     /region_name="SAPS"
                     /note="SIT4 phosphatase-associated protein; pfam04499"
                     /db_xref="CDD:398279"
     CDS             1..866
                     /gene="PPP6R3"
                     /gene_synonym="C11orf23; PP6R3; SAP190; SAPL; SAPLa;
                     SAPS3"
                     /coded_by="XM_054369263.1:361..2961"
                     /db_xref="GeneID:55291"
                     /db_xref="HGNC:HGNC:1173"
                     /db_xref="MIM:610879"
ORIGIN      
        1 mfwkfdlhss shidtllere dvtlkelmde edvlqeckaq nrkliefllk aecledlvsf
       61 iieeppqdmd ekirykypni scelltsdvs qmndrlgede sllmklysfl lndsplnpll
      121 asffskvlsi lisrkpeqiv dflkkkhdfv dliikhigts aimdlllrll tcieppqprq
      181 dvlnwlneek iiqrlveivh psqeedrhsn asqslceivr lsrdqmlqiq nstepdplla
      241 tlekqeiieq llsnifhkek nesaivsaiq illtlletrr ptfeghieic ppgmshsacs
      301 vnksvleair grlgsfhell leppkksvmk ttwgvldppv gntrlnvirl issllqtnts
      361 singdlmeln sigvilnmff kytwnnflht qveicialil aspfentena titdqdstgd
      421 nlllkhlfqk cqlierilea wemnekkqae ggrrhgymgh ltriancivh stdkgpnsal
      481 vqqlikdlpd evrerwetfc tsslgetnkr ntvdlvttch ihsssddeid fketgfsqds
      541 slqqfgfnde kfadqddign vsfdrvsdin ftlntnesgn ialfeaccke riqqfddggs
      601 deediweekh iaftpesqrr sssgstdsee stdseeedga kqdlfepssa ntedkmevdl
      661 seppnwsanf dvpmetthga pldsvgsdvw steepmptke tgwasfseft sslstkdslr
      721 snspvemets tepmdpltps aaalavqpea agsvameass dgeedaestd kvtetvmngg
      781 mketlsltvd aktetavfks eegklstsqd aackdaeecp etaeakcaap rppssspeqs
      841 asdacllllr tgqpsapgdt svngpv
//
LOCUS       XP_054225239             866 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform
            X5 [Homo sapiens].
ACCESSION   XP_054225239
VERSION     XP_054225239.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369264.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..866
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..866
                     /product="serine/threonine-protein phosphatase 6
                     regulatory subunit 3 isoform X5"
                     /calculated_mol_wt=96489
     Region          128..513
                     /region_name="SAPS"
                     /note="SIT4 phosphatase-associated protein; pfam04499"
                     /db_xref="CDD:398279"
     CDS             1..866
                     /gene="PPP6R3"
                     /gene_synonym="C11orf23; PP6R3; SAP190; SAPL; SAPLa;
                     SAPS3"
                     /coded_by="XM_054369264.1:234..2834"
                     /db_xref="GeneID:55291"
                     /db_xref="HGNC:HGNC:1173"
                     /db_xref="MIM:610879"
ORIGIN      
        1 mfwkfdlhss shidtllere dvtlkelmde edvlqeckaq nrkliefllk aecledlvsf
       61 iieeppqdmd ekirykypni scelltsdvs qmndrlgede sllmklysfl lndsplnpll
      121 asffskvlsi lisrkpeqiv dflkkkhdfv dliikhigts aimdlllrll tcieppqprq
      181 dvlnwlneek iiqrlveivh psqeedrhsn asqslceivr lsrdqmlqiq nstepdplla
      241 tlekqeiieq llsnifhkek nesaivsaiq illtlletrr ptfeghieic ppgmshsacs
      301 vnksvleair grlgsfhell leppkksvmk ttwgvldppv gntrlnvirl issllqtnts
      361 singdlmeln sigvilnmff kytwnnflht qveicialil aspfentena titdqdstgd
      421 nlllkhlfqk cqlierilea wemnekkqae ggrrhgymgh ltriancivh stdkgpnsal
      481 vqqlikdlpd evrerwetfc tsslgetnkr ntvdlvttch ihsssddeid fketgfsqds
      541 slqqfgfnde kfadqddign vsfdrvsdin ftlntnesgn ialfeaccke riqqfddggs
      601 deediweekh iaftpesqrr sssgstdsee stdseeedga kqdlfepssa ntedkmevdl
      661 seppnwsanf dvpmetthga pldsvgsdvw steepmptke tgwasfseft sslstkdslr
      721 snspvemets tepmdpltps aaalavqpea agsvameass dgeedaestd kvtetvmngg
      781 mketlsltvd aktetavfks eegklstsqd aackdaeecp etaeakcaap rppssspeqs
      841 asdacllllr tgqpsapgdt svngpv
//
LOCUS       XP_054225240             856 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform
            X6 [Homo sapiens].
ACCESSION   XP_054225240
VERSION     XP_054225240.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369265.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..856
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..856
                     /product="serine/threonine-protein phosphatase 6
                     regulatory subunit 3 isoform X6"
                     /calculated_mol_wt=95502
     Region          128..513
                     /region_name="SAPS"
                     /note="SIT4 phosphatase-associated protein; pfam04499"
                     /db_xref="CDD:398279"
     CDS             1..856
                     /gene="PPP6R3"
                     /gene_synonym="C11orf23; PP6R3; SAP190; SAPL; SAPLa;
                     SAPS3"
                     /coded_by="XM_054369265.1:339..2909"
                     /db_xref="GeneID:55291"
                     /db_xref="HGNC:HGNC:1173"
                     /db_xref="MIM:610879"
ORIGIN      
        1 mfwkfdlhss shidtllere dvtlkelmde edvlqeckaq nrkliefllk aecledlvsf
       61 iieeppqdmd ekirykypni scelltsdvs qmndrlgede sllmklysfl lndsplnpll
      121 asffskvlsi lisrkpeqiv dflkkkhdfv dliikhigts aimdlllrll tcieppqprq
      181 dvlnwlneek iiqrlveivh psqeedrhsn asqslceivr lsrdqmlqiq nstepdplla
      241 tlekqeiieq llsnifhkek nesaivsaiq illtlletrr ptfeghieic ppgmshsacs
      301 vnksvleair grlgsfhell leppkksvmk ttwgvldppv gntrlnvirl issllqtnts
      361 singdlmeln sigvilnmff kytwnnflht qveicialil aspfentena titdqdstgd
      421 nlllkhlfqk cqlierilea wemnekkqae ggrrhgymgh ltriancivh stdkgpnsal
      481 vqqlikdlpd evrerwetfc tsslgetnkr ntvdlvttch ihsssddeid fketgfsqds
      541 slqqfgfnde kfadqddign vsfdrvsdin ftlntnesgn ialfeaccke riqqfddggs
      601 deediweekh iaftpesqrr sssgstdsee stdseeedga kqdlfepssa ntedkmevdl
      661 seppnwsanf dvpmetthga pldsvgsdvw steepmptke tgwasfseft sslstkdslr
      721 snspvemets tepmdpltps aaalavqpea agsvameass dgeedaestd kvtetvmngg
      781 mketlsltvd aktetavfks eegklstsqd aackdaeecp etaeakcaap rppssspeqr
      841 tgqpsapgdt svngpv
//
LOCUS       XP_054225241             856 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform
            X6 [Homo sapiens].
ACCESSION   XP_054225241
VERSION     XP_054225241.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369266.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..856
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..856
                     /product="serine/threonine-protein phosphatase 6
                     regulatory subunit 3 isoform X6"
                     /calculated_mol_wt=95502
     Region          128..513
                     /region_name="SAPS"
                     /note="SIT4 phosphatase-associated protein; pfam04499"
                     /db_xref="CDD:398279"
     CDS             1..856
                     /gene="PPP6R3"
                     /gene_synonym="C11orf23; PP6R3; SAP190; SAPL; SAPLa;
                     SAPS3"
                     /coded_by="XM_054369266.1:557..3127"
                     /db_xref="GeneID:55291"
                     /db_xref="HGNC:HGNC:1173"
                     /db_xref="MIM:610879"
ORIGIN      
        1 mfwkfdlhss shidtllere dvtlkelmde edvlqeckaq nrkliefllk aecledlvsf
       61 iieeppqdmd ekirykypni scelltsdvs qmndrlgede sllmklysfl lndsplnpll
      121 asffskvlsi lisrkpeqiv dflkkkhdfv dliikhigts aimdlllrll tcieppqprq
      181 dvlnwlneek iiqrlveivh psqeedrhsn asqslceivr lsrdqmlqiq nstepdplla
      241 tlekqeiieq llsnifhkek nesaivsaiq illtlletrr ptfeghieic ppgmshsacs
      301 vnksvleair grlgsfhell leppkksvmk ttwgvldppv gntrlnvirl issllqtnts
      361 singdlmeln sigvilnmff kytwnnflht qveicialil aspfentena titdqdstgd
      421 nlllkhlfqk cqlierilea wemnekkqae ggrrhgymgh ltriancivh stdkgpnsal
      481 vqqlikdlpd evrerwetfc tsslgetnkr ntvdlvttch ihsssddeid fketgfsqds
      541 slqqfgfnde kfadqddign vsfdrvsdin ftlntnesgn ialfeaccke riqqfddggs
      601 deediweekh iaftpesqrr sssgstdsee stdseeedga kqdlfepssa ntedkmevdl
      661 seppnwsanf dvpmetthga pldsvgsdvw steepmptke tgwasfseft sslstkdslr
      721 snspvemets tepmdpltps aaalavqpea agsvameass dgeedaestd kvtetvmngg
      781 mketlsltvd aktetavfks eegklstsqd aackdaeecp etaeakcaap rppssspeqr
      841 tgqpsapgdt svngpv
//
LOCUS       XP_054225242             856 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform
            X6 [Homo sapiens].
ACCESSION   XP_054225242
VERSION     XP_054225242.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369267.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..856
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..856
                     /product="serine/threonine-protein phosphatase 6
                     regulatory subunit 3 isoform X6"
                     /calculated_mol_wt=95502
     Region          128..513
                     /region_name="SAPS"
                     /note="SIT4 phosphatase-associated protein; pfam04499"
                     /db_xref="CDD:398279"
     CDS             1..856
                     /gene="PPP6R3"
                     /gene_synonym="C11orf23; PP6R3; SAP190; SAPL; SAPLa;
                     SAPS3"
                     /coded_by="XM_054369267.1:535..3105"
                     /db_xref="GeneID:55291"
                     /db_xref="HGNC:HGNC:1173"
                     /db_xref="MIM:610879"
ORIGIN      
        1 mfwkfdlhss shidtllere dvtlkelmde edvlqeckaq nrkliefllk aecledlvsf
       61 iieeppqdmd ekirykypni scelltsdvs qmndrlgede sllmklysfl lndsplnpll
      121 asffskvlsi lisrkpeqiv dflkkkhdfv dliikhigts aimdlllrll tcieppqprq
      181 dvlnwlneek iiqrlveivh psqeedrhsn asqslceivr lsrdqmlqiq nstepdplla
      241 tlekqeiieq llsnifhkek nesaivsaiq illtlletrr ptfeghieic ppgmshsacs
      301 vnksvleair grlgsfhell leppkksvmk ttwgvldppv gntrlnvirl issllqtnts
      361 singdlmeln sigvilnmff kytwnnflht qveicialil aspfentena titdqdstgd
      421 nlllkhlfqk cqlierilea wemnekkqae ggrrhgymgh ltriancivh stdkgpnsal
      481 vqqlikdlpd evrerwetfc tsslgetnkr ntvdlvttch ihsssddeid fketgfsqds
      541 slqqfgfnde kfadqddign vsfdrvsdin ftlntnesgn ialfeaccke riqqfddggs
      601 deediweekh iaftpesqrr sssgstdsee stdseeedga kqdlfepssa ntedkmevdl
      661 seppnwsanf dvpmetthga pldsvgsdvw steepmptke tgwasfseft sslstkdslr
      721 snspvemets tepmdpltps aaalavqpea agsvameass dgeedaestd kvtetvmngg
      781 mketlsltvd aktetavfks eegklstsqd aackdaeecp etaeakcaap rppssspeqr
      841 tgqpsapgdt svngpv
//
LOCUS       XP_054225243             856 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform
            X6 [Homo sapiens].
ACCESSION   XP_054225243
VERSION     XP_054225243.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369268.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..856
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..856
                     /product="serine/threonine-protein phosphatase 6
                     regulatory subunit 3 isoform X6"
                     /calculated_mol_wt=95502
     Region          128..513
                     /region_name="SAPS"
                     /note="SIT4 phosphatase-associated protein; pfam04499"
                     /db_xref="CDD:398279"
     CDS             1..856
                     /gene="PPP6R3"
                     /gene_synonym="C11orf23; PP6R3; SAP190; SAPL; SAPLa;
                     SAPS3"
                     /coded_by="XM_054369268.1:430..3000"
                     /db_xref="GeneID:55291"
                     /db_xref="HGNC:HGNC:1173"
                     /db_xref="MIM:610879"
ORIGIN      
        1 mfwkfdlhss shidtllere dvtlkelmde edvlqeckaq nrkliefllk aecledlvsf
       61 iieeppqdmd ekirykypni scelltsdvs qmndrlgede sllmklysfl lndsplnpll
      121 asffskvlsi lisrkpeqiv dflkkkhdfv dliikhigts aimdlllrll tcieppqprq
      181 dvlnwlneek iiqrlveivh psqeedrhsn asqslceivr lsrdqmlqiq nstepdplla
      241 tlekqeiieq llsnifhkek nesaivsaiq illtlletrr ptfeghieic ppgmshsacs
      301 vnksvleair grlgsfhell leppkksvmk ttwgvldppv gntrlnvirl issllqtnts
      361 singdlmeln sigvilnmff kytwnnflht qveicialil aspfentena titdqdstgd
      421 nlllkhlfqk cqlierilea wemnekkqae ggrrhgymgh ltriancivh stdkgpnsal
      481 vqqlikdlpd evrerwetfc tsslgetnkr ntvdlvttch ihsssddeid fketgfsqds
      541 slqqfgfnde kfadqddign vsfdrvsdin ftlntnesgn ialfeaccke riqqfddggs
      601 deediweekh iaftpesqrr sssgstdsee stdseeedga kqdlfepssa ntedkmevdl
      661 seppnwsanf dvpmetthga pldsvgsdvw steepmptke tgwasfseft sslstkdslr
      721 snspvemets tepmdpltps aaalavqpea agsvameass dgeedaestd kvtetvmngg
      781 mketlsltvd aktetavfks eegklstsqd aackdaeecp etaeakcaap rppssspeqr
      841 tgqpsapgdt svngpv
//
LOCUS       XP_054225244             856 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform
            X6 [Homo sapiens].
ACCESSION   XP_054225244
VERSION     XP_054225244.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369269.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..856
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..856
                     /product="serine/threonine-protein phosphatase 6
                     regulatory subunit 3 isoform X6"
                     /calculated_mol_wt=95502
     Region          128..513
                     /region_name="SAPS"
                     /note="SIT4 phosphatase-associated protein; pfam04499"
                     /db_xref="CDD:398279"
     CDS             1..856
                     /gene="PPP6R3"
                     /gene_synonym="C11orf23; PP6R3; SAP190; SAPL; SAPLa;
                     SAPS3"
                     /coded_by="XM_054369269.1:361..2931"
                     /db_xref="GeneID:55291"
                     /db_xref="HGNC:HGNC:1173"
                     /db_xref="MIM:610879"
ORIGIN      
        1 mfwkfdlhss shidtllere dvtlkelmde edvlqeckaq nrkliefllk aecledlvsf
       61 iieeppqdmd ekirykypni scelltsdvs qmndrlgede sllmklysfl lndsplnpll
      121 asffskvlsi lisrkpeqiv dflkkkhdfv dliikhigts aimdlllrll tcieppqprq
      181 dvlnwlneek iiqrlveivh psqeedrhsn asqslceivr lsrdqmlqiq nstepdplla
      241 tlekqeiieq llsnifhkek nesaivsaiq illtlletrr ptfeghieic ppgmshsacs
      301 vnksvleair grlgsfhell leppkksvmk ttwgvldppv gntrlnvirl issllqtnts
      361 singdlmeln sigvilnmff kytwnnflht qveicialil aspfentena titdqdstgd
      421 nlllkhlfqk cqlierilea wemnekkqae ggrrhgymgh ltriancivh stdkgpnsal
      481 vqqlikdlpd evrerwetfc tsslgetnkr ntvdlvttch ihsssddeid fketgfsqds
      541 slqqfgfnde kfadqddign vsfdrvsdin ftlntnesgn ialfeaccke riqqfddggs
      601 deediweekh iaftpesqrr sssgstdsee stdseeedga kqdlfepssa ntedkmevdl
      661 seppnwsanf dvpmetthga pldsvgsdvw steepmptke tgwasfseft sslstkdslr
      721 snspvemets tepmdpltps aaalavqpea agsvameass dgeedaestd kvtetvmngg
      781 mketlsltvd aktetavfks eegklstsqd aackdaeecp etaeakcaap rppssspeqr
      841 tgqpsapgdt svngpv
//
LOCUS       XP_054225245             854 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform
            X7 [Homo sapiens].
ACCESSION   XP_054225245
VERSION     XP_054225245.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369270.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..854
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..854
                     /product="serine/threonine-protein phosphatase 6
                     regulatory subunit 3 isoform X7"
                     /calculated_mol_wt=95301
     Region          128..513
                     /region_name="SAPS"
                     /note="SIT4 phosphatase-associated protein; pfam04499"
                     /db_xref="CDD:398279"
     CDS             1..854
                     /gene="PPP6R3"
                     /gene_synonym="C11orf23; PP6R3; SAP190; SAPL; SAPLa;
                     SAPS3"
                     /coded_by="XM_054369270.1:361..2925"
                     /db_xref="GeneID:55291"
                     /db_xref="HGNC:HGNC:1173"
                     /db_xref="MIM:610879"
ORIGIN      
        1 mfwkfdlhss shidtllere dvtlkelmde edvlqeckaq nrkliefllk aecledlvsf
       61 iieeppqdmd ekirykypni scelltsdvs qmndrlgede sllmklysfl lndsplnpll
      121 asffskvlsi lisrkpeqiv dflkkkhdfv dliikhigts aimdlllrll tcieppqprq
      181 dvlnwlneek iiqrlveivh psqeedrhsn asqslceivr lsrdqmlqiq nstepdplla
      241 tlekqeiieq llsnifhkek nesaivsaiq illtlletrr ptfeghieic ppgmshsacs
      301 vnksvleair grlgsfhell leppkksvmk ttwgvldppv gntrlnvirl issllqtnts
      361 singdlmeln sigvilnmff kytwnnflht qveicialil aspfentena titdqdstgd
      421 nlllkhlfqk cqlierilea wemnekkqae ggrrhgymgh ltriancivh stdkgpnsal
      481 vqqlikdlpd evrerwetfc tsslgetnkr ntvdlafsdy qmqqmtsnfi dqfgfndekf
      541 adqddignvs fdrvsdinft lntnesgnia lfeacckeri qqfddggsde ediweekhia
      601 ftpesqrrss sgstdseest dseeedgakq dlfepssant edkmevdlse ppnwsanfdv
      661 pmetthgapl dsvgsdvwst eepmptketg wasfseftss lstkdslrsn spvemetste
      721 pmdpltpsaa alavqpeaag svameassdg eedaestdkv tetvmnggmk etlsltvdak
      781 tetavfksee gklstsqdaa ckdaeecpet aeakcaaprp pssspeqsas dacllllrtg
      841 qpsapgdtsv ngpv
//
LOCUS       XP_054225246             854 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform
            X7 [Homo sapiens].
ACCESSION   XP_054225246
VERSION     XP_054225246.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369271.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..854
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..854
                     /product="serine/threonine-protein phosphatase 6
                     regulatory subunit 3 isoform X7"
                     /calculated_mol_wt=95301
     Region          128..513
                     /region_name="SAPS"
                     /note="SIT4 phosphatase-associated protein; pfam04499"
                     /db_xref="CDD:398279"
     CDS             1..854
                     /gene="PPP6R3"
                     /gene_synonym="C11orf23; PP6R3; SAP190; SAPL; SAPLa;
                     SAPS3"
                     /coded_by="XM_054369271.1:339..2903"
                     /db_xref="GeneID:55291"
                     /db_xref="HGNC:HGNC:1173"
                     /db_xref="MIM:610879"
ORIGIN      
        1 mfwkfdlhss shidtllere dvtlkelmde edvlqeckaq nrkliefllk aecledlvsf
       61 iieeppqdmd ekirykypni scelltsdvs qmndrlgede sllmklysfl lndsplnpll
      121 asffskvlsi lisrkpeqiv dflkkkhdfv dliikhigts aimdlllrll tcieppqprq
      181 dvlnwlneek iiqrlveivh psqeedrhsn asqslceivr lsrdqmlqiq nstepdplla
      241 tlekqeiieq llsnifhkek nesaivsaiq illtlletrr ptfeghieic ppgmshsacs
      301 vnksvleair grlgsfhell leppkksvmk ttwgvldppv gntrlnvirl issllqtnts
      361 singdlmeln sigvilnmff kytwnnflht qveicialil aspfentena titdqdstgd
      421 nlllkhlfqk cqlierilea wemnekkqae ggrrhgymgh ltriancivh stdkgpnsal
      481 vqqlikdlpd evrerwetfc tsslgetnkr ntvdlafsdy qmqqmtsnfi dqfgfndekf
      541 adqddignvs fdrvsdinft lntnesgnia lfeacckeri qqfddggsde ediweekhia
      601 ftpesqrrss sgstdseest dseeedgakq dlfepssant edkmevdlse ppnwsanfdv
      661 pmetthgapl dsvgsdvwst eepmptketg wasfseftss lstkdslrsn spvemetste
      721 pmdpltpsaa alavqpeaag svameassdg eedaestdkv tetvmnggmk etlsltvdak
      781 tetavfksee gklstsqdaa ckdaeecpet aeakcaaprp pssspeqsas dacllllrtg
      841 qpsapgdtsv ngpv
//
LOCUS       XP_054225247             854 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform
            X7 [Homo sapiens].
ACCESSION   XP_054225247
VERSION     XP_054225247.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369272.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..854
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..854
                     /product="serine/threonine-protein phosphatase 6
                     regulatory subunit 3 isoform X7"
                     /calculated_mol_wt=95301
     Region          128..513
                     /region_name="SAPS"
                     /note="SIT4 phosphatase-associated protein; pfam04499"
                     /db_xref="CDD:398279"
     CDS             1..854
                     /gene="PPP6R3"
                     /gene_synonym="C11orf23; PP6R3; SAP190; SAPL; SAPLa;
                     SAPS3"
                     /coded_by="XM_054369272.1:234..2798"
                     /db_xref="GeneID:55291"
                     /db_xref="HGNC:HGNC:1173"
                     /db_xref="MIM:610879"
ORIGIN      
        1 mfwkfdlhss shidtllere dvtlkelmde edvlqeckaq nrkliefllk aecledlvsf
       61 iieeppqdmd ekirykypni scelltsdvs qmndrlgede sllmklysfl lndsplnpll
      121 asffskvlsi lisrkpeqiv dflkkkhdfv dliikhigts aimdlllrll tcieppqprq
      181 dvlnwlneek iiqrlveivh psqeedrhsn asqslceivr lsrdqmlqiq nstepdplla
      241 tlekqeiieq llsnifhkek nesaivsaiq illtlletrr ptfeghieic ppgmshsacs
      301 vnksvleair grlgsfhell leppkksvmk ttwgvldppv gntrlnvirl issllqtnts
      361 singdlmeln sigvilnmff kytwnnflht qveicialil aspfentena titdqdstgd
      421 nlllkhlfqk cqlierilea wemnekkqae ggrrhgymgh ltriancivh stdkgpnsal
      481 vqqlikdlpd evrerwetfc tsslgetnkr ntvdlafsdy qmqqmtsnfi dqfgfndekf
      541 adqddignvs fdrvsdinft lntnesgnia lfeacckeri qqfddggsde ediweekhia
      601 ftpesqrrss sgstdseest dseeedgakq dlfepssant edkmevdlse ppnwsanfdv
      661 pmetthgapl dsvgsdvwst eepmptketg wasfseftss lstkdslrsn spvemetste
      721 pmdpltpsaa alavqpeaag svameassdg eedaestdkv tetvmnggmk etlsltvdak
      781 tetavfksee gklstsqdaa ckdaeecpet aeakcaaprp pssspeqsas dacllllrtg
      841 qpsapgdtsv ngpv
//
LOCUS       XP_054225248             844 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform
            X8 [Homo sapiens].
ACCESSION   XP_054225248
VERSION     XP_054225248.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369273.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..844
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..844
                     /product="serine/threonine-protein phosphatase 6
                     regulatory subunit 3 isoform X8"
                     /calculated_mol_wt=94314
     Region          128..513
                     /region_name="SAPS"
                     /note="SIT4 phosphatase-associated protein; pfam04499"
                     /db_xref="CDD:398279"
     CDS             1..844
                     /gene="PPP6R3"
                     /gene_synonym="C11orf23; PP6R3; SAP190; SAPL; SAPLa;
                     SAPS3"
                     /coded_by="XM_054369273.1:339..2873"
                     /db_xref="GeneID:55291"
                     /db_xref="HGNC:HGNC:1173"
                     /db_xref="MIM:610879"
ORIGIN      
        1 mfwkfdlhss shidtllere dvtlkelmde edvlqeckaq nrkliefllk aecledlvsf
       61 iieeppqdmd ekirykypni scelltsdvs qmndrlgede sllmklysfl lndsplnpll
      121 asffskvlsi lisrkpeqiv dflkkkhdfv dliikhigts aimdlllrll tcieppqprq
      181 dvlnwlneek iiqrlveivh psqeedrhsn asqslceivr lsrdqmlqiq nstepdplla
      241 tlekqeiieq llsnifhkek nesaivsaiq illtlletrr ptfeghieic ppgmshsacs
      301 vnksvleair grlgsfhell leppkksvmk ttwgvldppv gntrlnvirl issllqtnts
      361 singdlmeln sigvilnmff kytwnnflht qveicialil aspfentena titdqdstgd
      421 nlllkhlfqk cqlierilea wemnekkqae ggrrhgymgh ltriancivh stdkgpnsal
      481 vqqlikdlpd evrerwetfc tsslgetnkr ntvdlafsdy qmqqmtsnfi dqfgfndekf
      541 adqddignvs fdrvsdinft lntnesgnia lfeacckeri qqfddggsde ediweekhia
      601 ftpesqrrss sgstdseest dseeedgakq dlfepssant edkmevdlse ppnwsanfdv
      661 pmetthgapl dsvgsdvwst eepmptketg wasfseftss lstkdslrsn spvemetste
      721 pmdpltpsaa alavqpeaag svameassdg eedaestdkv tetvmnggmk etlsltvdak
      781 tetavfksee gklstsqdaa ckdaeecpet aeakcaaprp pssspeqrtg qpsapgdtsv
      841 ngpv
//
LOCUS       XP_054225249             838 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform
            X9 [Homo sapiens].
ACCESSION   XP_054225249
VERSION     XP_054225249.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369274.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..838
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..838
                     /product="serine/threonine-protein phosphatase 6
                     regulatory subunit 3 isoform X9"
                     /calculated_mol_wt=93602
     Region          128..513
                     /region_name="SAPS"
                     /note="SIT4 phosphatase-associated protein; pfam04499"
                     /db_xref="CDD:398279"
     CDS             1..838
                     /gene="PPP6R3"
                     /gene_synonym="C11orf23; PP6R3; SAP190; SAPL; SAPLa;
                     SAPS3"
                     /coded_by="XM_054369274.1:361..2877"
                     /db_xref="GeneID:55291"
                     /db_xref="HGNC:HGNC:1173"
                     /db_xref="MIM:610879"
ORIGIN      
        1 mfwkfdlhss shidtllere dvtlkelmde edvlqeckaq nrkliefllk aecledlvsf
       61 iieeppqdmd ekirykypni scelltsdvs qmndrlgede sllmklysfl lndsplnpll
      121 asffskvlsi lisrkpeqiv dflkkkhdfv dliikhigts aimdlllrll tcieppqprq
      181 dvlnwlneek iiqrlveivh psqeedrhsn asqslceivr lsrdqmlqiq nstepdplla
      241 tlekqeiieq llsnifhkek nesaivsaiq illtlletrr ptfeghieic ppgmshsacs
      301 vnksvleair grlgsfhell leppkksvmk ttwgvldppv gntrlnvirl issllqtnts
      361 singdlmeln sigvilnmff kytwnnflht qveicialil aspfentena titdqdstgd
      421 nlllkhlfqk cqlierilea wemnekkqae ggrrhgymgh ltriancivh stdkgpnsal
      481 vqqlikdlpd evrerwetfc tsslgetnkr ntvdlmqqmt snfidqfgfn dekfadqddi
      541 gnvsfdrvsd inftlntnes gnialfeacc keriqqfddg gsdeediwee khiaftpesq
      601 rrsssgstds eestdseeed gakqdlfeps santedkmev dlseppnwsa nfdvpmetth
      661 gapldsvgsd vwsteepmpt ketgwasfse ftsslstkds lrsnspveme tstepmdplt
      721 psaaalavqp eaagsvamea ssdgeedaes tdkvtetvmn ggmketlslt vdaktetavf
      781 kseegklsts qdaackdaee cpetaeakca aprppssspe qrtgqpsapg dtsvngpv
//
LOCUS       XP_054225250             838 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform
            X9 [Homo sapiens].
ACCESSION   XP_054225250
VERSION     XP_054225250.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369275.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..838
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..838
                     /product="serine/threonine-protein phosphatase 6
                     regulatory subunit 3 isoform X9"
                     /calculated_mol_wt=93602
     Region          128..513
                     /region_name="SAPS"
                     /note="SIT4 phosphatase-associated protein; pfam04499"
                     /db_xref="CDD:398279"
     CDS             1..838
                     /gene="PPP6R3"
                     /gene_synonym="C11orf23; PP6R3; SAP190; SAPL; SAPLa;
                     SAPS3"
                     /coded_by="XM_054369275.1:234..2750"
                     /db_xref="GeneID:55291"
                     /db_xref="HGNC:HGNC:1173"
                     /db_xref="MIM:610879"
ORIGIN      
        1 mfwkfdlhss shidtllere dvtlkelmde edvlqeckaq nrkliefllk aecledlvsf
       61 iieeppqdmd ekirykypni scelltsdvs qmndrlgede sllmklysfl lndsplnpll
      121 asffskvlsi lisrkpeqiv dflkkkhdfv dliikhigts aimdlllrll tcieppqprq
      181 dvlnwlneek iiqrlveivh psqeedrhsn asqslceivr lsrdqmlqiq nstepdplla
      241 tlekqeiieq llsnifhkek nesaivsaiq illtlletrr ptfeghieic ppgmshsacs
      301 vnksvleair grlgsfhell leppkksvmk ttwgvldppv gntrlnvirl issllqtnts
      361 singdlmeln sigvilnmff kytwnnflht qveicialil aspfentena titdqdstgd
      421 nlllkhlfqk cqlierilea wemnekkqae ggrrhgymgh ltriancivh stdkgpnsal
      481 vqqlikdlpd evrerwetfc tsslgetnkr ntvdlmqqmt snfidqfgfn dekfadqddi
      541 gnvsfdrvsd inftlntnes gnialfeacc keriqqfddg gsdeediwee khiaftpesq
      601 rrsssgstds eestdseeed gakqdlfeps santedkmev dlseppnwsa nfdvpmetth
      661 gapldsvgsd vwsteepmpt ketgwasfse ftsslstkds lrsnspveme tstepmdplt
      721 psaaalavqp eaagsvamea ssdgeedaes tdkvtetvmn ggmketlslt vdaktetavf
      781 kseegklsts qdaackdaee cpetaeakca aprppssspe qrtgqpsapg dtsvngpv
//
LOCUS       XP_054225251             827 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform
            X10 [Homo sapiens].
ACCESSION   XP_054225251
VERSION     XP_054225251.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369276.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..827
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..827
                     /product="serine/threonine-protein phosphatase 6
                     regulatory subunit 3 isoform X10"
                     /calculated_mol_wt=92278
     Region          128..513
                     /region_name="SAPS"
                     /note="SIT4 phosphatase-associated protein; pfam04499"
                     /db_xref="CDD:398279"
     CDS             1..827
                     /gene="PPP6R3"
                     /gene_synonym="C11orf23; PP6R3; SAP190; SAPL; SAPLa;
                     SAPS3"
                     /coded_by="XM_054369276.1:361..2844"
                     /db_xref="GeneID:55291"
                     /db_xref="HGNC:HGNC:1173"
                     /db_xref="MIM:610879"
ORIGIN      
        1 mfwkfdlhss shidtllere dvtlkelmde edvlqeckaq nrkliefllk aecledlvsf
       61 iieeppqdmd ekirykypni scelltsdvs qmndrlgede sllmklysfl lndsplnpll
      121 asffskvlsi lisrkpeqiv dflkkkhdfv dliikhigts aimdlllrll tcieppqprq
      181 dvlnwlneek iiqrlveivh psqeedrhsn asqslceivr lsrdqmlqiq nstepdplla
      241 tlekqeiieq llsnifhkek nesaivsaiq illtlletrr ptfeghieic ppgmshsacs
      301 vnksvleair grlgsfhell leppkksvmk ttwgvldppv gntrlnvirl issllqtnts
      361 singdlmeln sigvilnmff kytwnnflht qveicialil aspfentena titdqdstgd
      421 nlllkhlfqk cqlierilea wemnekkqae ggrrhgymgh ltriancivh stdkgpnsal
      481 vqqlikdlpd evrerwetfc tsslgetnkr ntvdlfgfnd ekfadqddig nvsfdrvsdi
      541 nftlntnesg nialfeacck eriqqfddgg sdeediweek hiaftpesqr rsssgstdse
      601 estdseeedg akqdlfepss antedkmevd lseppnwsan fdvpmetthg apldsvgsdv
      661 wsteepmptk etgwasfsef tsslstkdsl rsnspvemet stepmdpltp saaalavqpe
      721 aagsvameas sdgeedaest dkvtetvmng gmketlsltv daktetavfk seegklstsq
      781 daackdaeec petaeakcaa prppssspeq rtgqpsapgd tsvngpv
//
LOCUS       XP_054225252             827 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform
            X10 [Homo sapiens].
ACCESSION   XP_054225252
VERSION     XP_054225252.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369277.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..827
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..827
                     /product="serine/threonine-protein phosphatase 6
                     regulatory subunit 3 isoform X10"
                     /calculated_mol_wt=92278
     Region          128..513
                     /region_name="SAPS"
                     /note="SIT4 phosphatase-associated protein; pfam04499"
                     /db_xref="CDD:398279"
     CDS             1..827
                     /gene="PPP6R3"
                     /gene_synonym="C11orf23; PP6R3; SAP190; SAPL; SAPLa;
                     SAPS3"
                     /coded_by="XM_054369277.1:339..2822"
                     /db_xref="GeneID:55291"
                     /db_xref="HGNC:HGNC:1173"
                     /db_xref="MIM:610879"
ORIGIN      
        1 mfwkfdlhss shidtllere dvtlkelmde edvlqeckaq nrkliefllk aecledlvsf
       61 iieeppqdmd ekirykypni scelltsdvs qmndrlgede sllmklysfl lndsplnpll
      121 asffskvlsi lisrkpeqiv dflkkkhdfv dliikhigts aimdlllrll tcieppqprq
      181 dvlnwlneek iiqrlveivh psqeedrhsn asqslceivr lsrdqmlqiq nstepdplla
      241 tlekqeiieq llsnifhkek nesaivsaiq illtlletrr ptfeghieic ppgmshsacs
      301 vnksvleair grlgsfhell leppkksvmk ttwgvldppv gntrlnvirl issllqtnts
      361 singdlmeln sigvilnmff kytwnnflht qveicialil aspfentena titdqdstgd
      421 nlllkhlfqk cqlierilea wemnekkqae ggrrhgymgh ltriancivh stdkgpnsal
      481 vqqlikdlpd evrerwetfc tsslgetnkr ntvdlfgfnd ekfadqddig nvsfdrvsdi
      541 nftlntnesg nialfeacck eriqqfddgg sdeediweek hiaftpesqr rsssgstdse
      601 estdseeedg akqdlfepss antedkmevd lseppnwsan fdvpmetthg apldsvgsdv
      661 wsteepmptk etgwasfsef tsslstkdsl rsnspvemet stepmdpltp saaalavqpe
      721 aagsvameas sdgeedaest dkvtetvmng gmketlsltv daktetavfk seegklstsq
      781 daackdaeec petaeakcaa prppssspeq rtgqpsapgd tsvngpv
//
LOCUS       XP_054225253             827 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform
            X10 [Homo sapiens].
ACCESSION   XP_054225253
VERSION     XP_054225253.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369278.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..827
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..827
                     /product="serine/threonine-protein phosphatase 6
                     regulatory subunit 3 isoform X10"
                     /calculated_mol_wt=92278
     Region          128..513
                     /region_name="SAPS"
                     /note="SIT4 phosphatase-associated protein; pfam04499"
                     /db_xref="CDD:398279"
     CDS             1..827
                     /gene="PPP6R3"
                     /gene_synonym="C11orf23; PP6R3; SAP190; SAPL; SAPLa;
                     SAPS3"
                     /coded_by="XM_054369278.1:234..2717"
                     /db_xref="GeneID:55291"
                     /db_xref="HGNC:HGNC:1173"
                     /db_xref="MIM:610879"
ORIGIN      
        1 mfwkfdlhss shidtllere dvtlkelmde edvlqeckaq nrkliefllk aecledlvsf
       61 iieeppqdmd ekirykypni scelltsdvs qmndrlgede sllmklysfl lndsplnpll
      121 asffskvlsi lisrkpeqiv dflkkkhdfv dliikhigts aimdlllrll tcieppqprq
      181 dvlnwlneek iiqrlveivh psqeedrhsn asqslceivr lsrdqmlqiq nstepdplla
      241 tlekqeiieq llsnifhkek nesaivsaiq illtlletrr ptfeghieic ppgmshsacs
      301 vnksvleair grlgsfhell leppkksvmk ttwgvldppv gntrlnvirl issllqtnts
      361 singdlmeln sigvilnmff kytwnnflht qveicialil aspfentena titdqdstgd
      421 nlllkhlfqk cqlierilea wemnekkqae ggrrhgymgh ltriancivh stdkgpnsal
      481 vqqlikdlpd evrerwetfc tsslgetnkr ntvdlfgfnd ekfadqddig nvsfdrvsdi
      541 nftlntnesg nialfeacck eriqqfddgg sdeediweek hiaftpesqr rsssgstdse
      601 estdseeedg akqdlfepss antedkmevd lseppnwsan fdvpmetthg apldsvgsdv
      661 wsteepmptk etgwasfsef tsslstkdsl rsnspvemet stepmdpltp saaalavqpe
      721 aagsvameas sdgeedaest dkvtetvmng gmketlsltv daktetavfk seegklstsq
      781 daackdaeec petaeakcaa prppssspeq rtgqpsapgd tsvngpv
//
LOCUS       XP_054225254             822 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform
            X11 [Homo sapiens].
ACCESSION   XP_054225254
VERSION     XP_054225254.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369279.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..822
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..822
                     /product="serine/threonine-protein phosphatase 6
                     regulatory subunit 3 isoform X11"
                     /calculated_mol_wt=92046
     Region          128..462
                     /region_name="SAPS"
                     /note="SIT4 phosphatase-associated protein; pfam04499"
                     /db_xref="CDD:398279"
     CDS             1..822
                     /gene="PPP6R3"
                     /gene_synonym="C11orf23; PP6R3; SAP190; SAPL; SAPLa;
                     SAPS3"
                     /coded_by="XM_054369279.1:361..2829"
                     /db_xref="GeneID:55291"
                     /db_xref="HGNC:HGNC:1173"
                     /db_xref="MIM:610879"
ORIGIN      
        1 mfwkfdlhss shidtllere dvtlkelmde edvlqeckaq nrkliefllk aecledlvsf
       61 iieeppqdmd ekirykypni scelltsdvs qmndrlgede sllmklysfl lndsplnpll
      121 asffskvlsi lisrkpeqiv dflkkkhdfv dliikhigts aimdlllrll tcieppqprq
      181 dvlnwlneek iiqrlveivh psqeedrhsn asqslceivr lsrdqmlqiq nstepdplla
      241 tlekqeiieq llsnifhkek nesaivsaiq illtlletrr ptfeghieic ppgmshsacs
      301 vnksvleair grlgsfhell leppknmffk ytwnnflhtq veicialila spfentenat
      361 itdqdstgdn lllkhlfqkc qlierileaw emnekkqaeg grrhgymghl triancivhs
      421 tdkgpnsalv qqlikdlpde vrerwetfct sslgetnkrn tvdlvttchi hsssddeidf
      481 ketgfsqdss lqqafsdyqm qqmtsnfidq fgfndekfad qddignvsfd rvsdinftln
      541 tnesgnialf eacckeriqq fddggsdeed iweekhiaft pesqrrsssg stdseestds
      601 eeedgakqdl fepssanted kmevdlsepp nwsanfdvpm etthgaplds vgsdvwstee
      661 pmptketgwa sfseftssls tkdslrsnsp vemetstepm dpltpsaaal avqpeaagsv
      721 ameassdgee daestdkvte tvmnggmket lsltvdakte tavfkseegk lstsqdaack
      781 daeecpetae akcaaprpps sspeqrtgqp sapgdtsvng pv
//
LOCUS       XP_054225255             822 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform
            X11 [Homo sapiens].
ACCESSION   XP_054225255
VERSION     XP_054225255.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369280.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..822
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..822
                     /product="serine/threonine-protein phosphatase 6
                     regulatory subunit 3 isoform X11"
                     /calculated_mol_wt=92046
     Region          128..462
                     /region_name="SAPS"
                     /note="SIT4 phosphatase-associated protein; pfam04499"
                     /db_xref="CDD:398279"
     CDS             1..822
                     /gene="PPP6R3"
                     /gene_synonym="C11orf23; PP6R3; SAP190; SAPL; SAPLa;
                     SAPS3"
                     /coded_by="XM_054369280.1:234..2702"
                     /db_xref="GeneID:55291"
                     /db_xref="HGNC:HGNC:1173"
                     /db_xref="MIM:610879"
ORIGIN      
        1 mfwkfdlhss shidtllere dvtlkelmde edvlqeckaq nrkliefllk aecledlvsf
       61 iieeppqdmd ekirykypni scelltsdvs qmndrlgede sllmklysfl lndsplnpll
      121 asffskvlsi lisrkpeqiv dflkkkhdfv dliikhigts aimdlllrll tcieppqprq
      181 dvlnwlneek iiqrlveivh psqeedrhsn asqslceivr lsrdqmlqiq nstepdplla
      241 tlekqeiieq llsnifhkek nesaivsaiq illtlletrr ptfeghieic ppgmshsacs
      301 vnksvleair grlgsfhell leppknmffk ytwnnflhtq veicialila spfentenat
      361 itdqdstgdn lllkhlfqkc qlierileaw emnekkqaeg grrhgymghl triancivhs
      421 tdkgpnsalv qqlikdlpde vrerwetfct sslgetnkrn tvdlvttchi hsssddeidf
      481 ketgfsqdss lqqafsdyqm qqmtsnfidq fgfndekfad qddignvsfd rvsdinftln
      541 tnesgnialf eacckeriqq fddggsdeed iweekhiaft pesqrrsssg stdseestds
      601 eeedgakqdl fepssanted kmevdlsepp nwsanfdvpm etthgaplds vgsdvwstee
      661 pmptketgwa sfseftssls tkdslrsnsp vemetstepm dpltpsaaal avqpeaagsv
      721 ameassdgee daestdkvte tvmnggmket lsltvdakte tavfkseegk lstsqdaack
      781 daeecpetae akcaaprpps sspeqrtgqp sapgdtsvng pv
//
LOCUS       XP_054225256             822 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform
            X11 [Homo sapiens].
ACCESSION   XP_054225256
VERSION     XP_054225256.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369281.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..822
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..822
                     /product="serine/threonine-protein phosphatase 6
                     regulatory subunit 3 isoform X11"
                     /calculated_mol_wt=92046
     Region          128..462
                     /region_name="SAPS"
                     /note="SIT4 phosphatase-associated protein; pfam04499"
                     /db_xref="CDD:398279"
     CDS             1..822
                     /gene="PPP6R3"
                     /gene_synonym="C11orf23; PP6R3; SAP190; SAPL; SAPLa;
                     SAPS3"
                     /coded_by="XM_054369281.1:339..2807"
                     /db_xref="GeneID:55291"
                     /db_xref="HGNC:HGNC:1173"
                     /db_xref="MIM:610879"
ORIGIN      
        1 mfwkfdlhss shidtllere dvtlkelmde edvlqeckaq nrkliefllk aecledlvsf
       61 iieeppqdmd ekirykypni scelltsdvs qmndrlgede sllmklysfl lndsplnpll
      121 asffskvlsi lisrkpeqiv dflkkkhdfv dliikhigts aimdlllrll tcieppqprq
      181 dvlnwlneek iiqrlveivh psqeedrhsn asqslceivr lsrdqmlqiq nstepdplla
      241 tlekqeiieq llsnifhkek nesaivsaiq illtlletrr ptfeghieic ppgmshsacs
      301 vnksvleair grlgsfhell leppknmffk ytwnnflhtq veicialila spfentenat
      361 itdqdstgdn lllkhlfqkc qlierileaw emnekkqaeg grrhgymghl triancivhs
      421 tdkgpnsalv qqlikdlpde vrerwetfct sslgetnkrn tvdlvttchi hsssddeidf
      481 ketgfsqdss lqqafsdyqm qqmtsnfidq fgfndekfad qddignvsfd rvsdinftln
      541 tnesgnialf eacckeriqq fddggsdeed iweekhiaft pesqrrsssg stdseestds
      601 eeedgakqdl fepssanted kmevdlsepp nwsanfdvpm etthgaplds vgsdvwstee
      661 pmptketgwa sfseftssls tkdslrsnsp vemetstepm dpltpsaaal avqpeaagsv
      721 ameassdgee daestdkvte tvmnggmket lsltvdakte tavfkseegk lstsqdaack
      781 daeecpetae akcaaprpps sspeqrtgqp sapgdtsvng pv
//
LOCUS       XP_054225257             816 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform
            X12 [Homo sapiens].
ACCESSION   XP_054225257
VERSION     XP_054225257.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369282.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..816
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..816
                     /product="serine/threonine-protein phosphatase 6
                     regulatory subunit 3 isoform X12"
                     /calculated_mol_wt=91334
     Region          128..462
                     /region_name="SAPS"
                     /note="SIT4 phosphatase-associated protein; pfam04499"
                     /db_xref="CDD:398279"
     CDS             1..816
                     /gene="PPP6R3"
                     /gene_synonym="C11orf23; PP6R3; SAP190; SAPL; SAPLa;
                     SAPS3"
                     /coded_by="XM_054369282.1:361..2811"
                     /db_xref="GeneID:55291"
                     /db_xref="HGNC:HGNC:1173"
                     /db_xref="MIM:610879"
ORIGIN      
        1 mfwkfdlhss shidtllere dvtlkelmde edvlqeckaq nrkliefllk aecledlvsf
       61 iieeppqdmd ekirykypni scelltsdvs qmndrlgede sllmklysfl lndsplnpll
      121 asffskvlsi lisrkpeqiv dflkkkhdfv dliikhigts aimdlllrll tcieppqprq
      181 dvlnwlneek iiqrlveivh psqeedrhsn asqslceivr lsrdqmlqiq nstepdplla
      241 tlekqeiieq llsnifhkek nesaivsaiq illtlletrr ptfeghieic ppgmshsacs
      301 vnksvleair grlgsfhell leppknmffk ytwnnflhtq veicialila spfentenat
      361 itdqdstgdn lllkhlfqkc qlierileaw emnekkqaeg grrhgymghl triancivhs
      421 tdkgpnsalv qqlikdlpde vrerwetfct sslgetnkrn tvdlvttchi hsssddeidf
      481 ketgfsqdss lqqmqqmtsn fidqfgfnde kfadqddign vsfdrvsdin ftlntnesgn
      541 ialfeaccke riqqfddggs deediweekh iaftpesqrr sssgstdsee stdseeedga
      601 kqdlfepssa ntedkmevdl seppnwsanf dvpmetthga pldsvgsdvw steepmptke
      661 tgwasfseft sslstkdslr snspvemets tepmdpltps aaalavqpea agsvameass
      721 dgeedaestd kvtetvmngg mketlsltvd aktetavfks eegklstsqd aackdaeecp
      781 etaeakcaap rppssspeqr tgqpsapgdt svngpv
//
LOCUS       XP_054225258             816 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform
            X12 [Homo sapiens].
ACCESSION   XP_054225258
VERSION     XP_054225258.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369283.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..816
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..816
                     /product="serine/threonine-protein phosphatase 6
                     regulatory subunit 3 isoform X12"
                     /calculated_mol_wt=91334
     Region          128..462
                     /region_name="SAPS"
                     /note="SIT4 phosphatase-associated protein; pfam04499"
                     /db_xref="CDD:398279"
     CDS             1..816
                     /gene="PPP6R3"
                     /gene_synonym="C11orf23; PP6R3; SAP190; SAPL; SAPLa;
                     SAPS3"
                     /coded_by="XM_054369283.1:339..2789"
                     /db_xref="GeneID:55291"
                     /db_xref="HGNC:HGNC:1173"
                     /db_xref="MIM:610879"
ORIGIN      
        1 mfwkfdlhss shidtllere dvtlkelmde edvlqeckaq nrkliefllk aecledlvsf
       61 iieeppqdmd ekirykypni scelltsdvs qmndrlgede sllmklysfl lndsplnpll
      121 asffskvlsi lisrkpeqiv dflkkkhdfv dliikhigts aimdlllrll tcieppqprq
      181 dvlnwlneek iiqrlveivh psqeedrhsn asqslceivr lsrdqmlqiq nstepdplla
      241 tlekqeiieq llsnifhkek nesaivsaiq illtlletrr ptfeghieic ppgmshsacs
      301 vnksvleair grlgsfhell leppknmffk ytwnnflhtq veicialila spfentenat
      361 itdqdstgdn lllkhlfqkc qlierileaw emnekkqaeg grrhgymghl triancivhs
      421 tdkgpnsalv qqlikdlpde vrerwetfct sslgetnkrn tvdlvttchi hsssddeidf
      481 ketgfsqdss lqqmqqmtsn fidqfgfnde kfadqddign vsfdrvsdin ftlntnesgn
      541 ialfeaccke riqqfddggs deediweekh iaftpesqrr sssgstdsee stdseeedga
      601 kqdlfepssa ntedkmevdl seppnwsanf dvpmetthga pldsvgsdvw steepmptke
      661 tgwasfseft sslstkdslr snspvemets tepmdpltps aaalavqpea agsvameass
      721 dgeedaestd kvtetvmngg mketlsltvd aktetavfks eegklstsqd aackdaeecp
      781 etaeakcaap rppssspeqr tgqpsapgdt svngpv
//
LOCUS       XP_054225259             816 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform
            X12 [Homo sapiens].
ACCESSION   XP_054225259
VERSION     XP_054225259.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369284.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..816
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..816
                     /product="serine/threonine-protein phosphatase 6
                     regulatory subunit 3 isoform X12"
                     /calculated_mol_wt=91334
     Region          128..462
                     /region_name="SAPS"
                     /note="SIT4 phosphatase-associated protein; pfam04499"
                     /db_xref="CDD:398279"
     CDS             1..816
                     /gene="PPP6R3"
                     /gene_synonym="C11orf23; PP6R3; SAP190; SAPL; SAPLa;
                     SAPS3"
                     /coded_by="XM_054369284.1:234..2684"
                     /db_xref="GeneID:55291"
                     /db_xref="HGNC:HGNC:1173"
                     /db_xref="MIM:610879"
ORIGIN      
        1 mfwkfdlhss shidtllere dvtlkelmde edvlqeckaq nrkliefllk aecledlvsf
       61 iieeppqdmd ekirykypni scelltsdvs qmndrlgede sllmklysfl lndsplnpll
      121 asffskvlsi lisrkpeqiv dflkkkhdfv dliikhigts aimdlllrll tcieppqprq
      181 dvlnwlneek iiqrlveivh psqeedrhsn asqslceivr lsrdqmlqiq nstepdplla
      241 tlekqeiieq llsnifhkek nesaivsaiq illtlletrr ptfeghieic ppgmshsacs
      301 vnksvleair grlgsfhell leppknmffk ytwnnflhtq veicialila spfentenat
      361 itdqdstgdn lllkhlfqkc qlierileaw emnekkqaeg grrhgymghl triancivhs
      421 tdkgpnsalv qqlikdlpde vrerwetfct sslgetnkrn tvdlvttchi hsssddeidf
      481 ketgfsqdss lqqmqqmtsn fidqfgfnde kfadqddign vsfdrvsdin ftlntnesgn
      541 ialfeaccke riqqfddggs deediweekh iaftpesqrr sssgstdsee stdseeedga
      601 kqdlfepssa ntedkmevdl seppnwsanf dvpmetthga pldsvgsdvw steepmptke
      661 tgwasfseft sslstkdslr snspvemets tepmdpltps aaalavqpea agsvameass
      721 dgeedaestd kvtetvmngg mketlsltvd aktetavfks eegklstsqd aackdaeecp
      781 etaeakcaap rppssspeqr tgqpsapgdt svngpv
//
LOCUS       XP_054225260             805 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform
            X13 [Homo sapiens].
ACCESSION   XP_054225260
VERSION     XP_054225260.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369285.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..805
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..805
                     /product="serine/threonine-protein phosphatase 6
                     regulatory subunit 3 isoform X13"
                     /calculated_mol_wt=90010
     Region          128..462
                     /region_name="SAPS"
                     /note="SIT4 phosphatase-associated protein; pfam04499"
                     /db_xref="CDD:398279"
     CDS             1..805
                     /gene="PPP6R3"
                     /gene_synonym="C11orf23; PP6R3; SAP190; SAPL; SAPLa;
                     SAPS3"
                     /coded_by="XM_054369285.1:361..2778"
                     /db_xref="GeneID:55291"
                     /db_xref="HGNC:HGNC:1173"
                     /db_xref="MIM:610879"
ORIGIN      
        1 mfwkfdlhss shidtllere dvtlkelmde edvlqeckaq nrkliefllk aecledlvsf
       61 iieeppqdmd ekirykypni scelltsdvs qmndrlgede sllmklysfl lndsplnpll
      121 asffskvlsi lisrkpeqiv dflkkkhdfv dliikhigts aimdlllrll tcieppqprq
      181 dvlnwlneek iiqrlveivh psqeedrhsn asqslceivr lsrdqmlqiq nstepdplla
      241 tlekqeiieq llsnifhkek nesaivsaiq illtlletrr ptfeghieic ppgmshsacs
      301 vnksvleair grlgsfhell leppknmffk ytwnnflhtq veicialila spfentenat
      361 itdqdstgdn lllkhlfqkc qlierileaw emnekkqaeg grrhgymghl triancivhs
      421 tdkgpnsalv qqlikdlpde vrerwetfct sslgetnkrn tvdlvttchi hsssddeidf
      481 ketgfsqdss lqqfgfndek fadqddignv sfdrvsdinf tlntnesgni alfeaccker
      541 iqqfddggsd eediweekhi aftpesqrrs ssgstdsees tdseeedgak qdlfepssan
      601 tedkmevdls eppnwsanfd vpmetthgap ldsvgsdvws teepmptket gwasfsefts
      661 slstkdslrs nspvemetst epmdpltpsa aalavqpeaa gsvameassd geedaestdk
      721 vtetvmnggm ketlsltvda ktetavfkse egklstsqda ackdaeecpe taeakcaapr
      781 ppssspeqrt gqpsapgdts vngpv
//
LOCUS       XP_054225261             803 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform
            X14 [Homo sapiens].
ACCESSION   XP_054225261
VERSION     XP_054225261.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369286.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..803
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..803
                     /product="serine/threonine-protein phosphatase 6
                     regulatory subunit 3 isoform X14"
                     /calculated_mol_wt=89809
     Region          128..462
                     /region_name="SAPS"
                     /note="SIT4 phosphatase-associated protein; pfam04499"
                     /db_xref="CDD:398279"
     CDS             1..803
                     /gene="PPP6R3"
                     /gene_synonym="C11orf23; PP6R3; SAP190; SAPL; SAPLa;
                     SAPS3"
                     /coded_by="XM_054369286.1:339..2750"
                     /db_xref="GeneID:55291"
                     /db_xref="HGNC:HGNC:1173"
                     /db_xref="MIM:610879"
ORIGIN      
        1 mfwkfdlhss shidtllere dvtlkelmde edvlqeckaq nrkliefllk aecledlvsf
       61 iieeppqdmd ekirykypni scelltsdvs qmndrlgede sllmklysfl lndsplnpll
      121 asffskvlsi lisrkpeqiv dflkkkhdfv dliikhigts aimdlllrll tcieppqprq
      181 dvlnwlneek iiqrlveivh psqeedrhsn asqslceivr lsrdqmlqiq nstepdplla
      241 tlekqeiieq llsnifhkek nesaivsaiq illtlletrr ptfeghieic ppgmshsacs
      301 vnksvleair grlgsfhell leppknmffk ytwnnflhtq veicialila spfentenat
      361 itdqdstgdn lllkhlfqkc qlierileaw emnekkqaeg grrhgymghl triancivhs
      421 tdkgpnsalv qqlikdlpde vrerwetfct sslgetnkrn tvdlafsdyq mqqmtsnfid
      481 qfgfndekfa dqddignvsf drvsdinftl ntnesgnial feacckeriq qfddggsdee
      541 diweekhiaf tpesqrrsss gstdseestd seeedgakqd lfepssante dkmevdlsep
      601 pnwsanfdvp metthgapld svgsdvwste epmptketgw asfseftssl stkdslrsns
      661 pvemetstep mdpltpsaaa lavqpeaags vameassdge edaestdkvt etvmnggmke
      721 tlsltvdakt etavfkseeg klstsqdaac kdaeecpeta eakcaaprpp ssspeqsasd
      781 acllllrtgq psapgdtsvn gpv
//
LOCUS       XP_054225262             793 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform
            X15 [Homo sapiens].
ACCESSION   XP_054225262
VERSION     XP_054225262.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369287.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..793
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..793
                     /product="serine/threonine-protein phosphatase 6
                     regulatory subunit 3 isoform X15"
                     /calculated_mol_wt=88822
     Region          128..462
                     /region_name="SAPS"
                     /note="SIT4 phosphatase-associated protein; pfam04499"
                     /db_xref="CDD:398279"
     CDS             1..793
                     /gene="PPP6R3"
                     /gene_synonym="C11orf23; PP6R3; SAP190; SAPL; SAPLa;
                     SAPS3"
                     /coded_by="XM_054369287.1:361..2742"
                     /db_xref="GeneID:55291"
                     /db_xref="HGNC:HGNC:1173"
                     /db_xref="MIM:610879"
ORIGIN      
        1 mfwkfdlhss shidtllere dvtlkelmde edvlqeckaq nrkliefllk aecledlvsf
       61 iieeppqdmd ekirykypni scelltsdvs qmndrlgede sllmklysfl lndsplnpll
      121 asffskvlsi lisrkpeqiv dflkkkhdfv dliikhigts aimdlllrll tcieppqprq
      181 dvlnwlneek iiqrlveivh psqeedrhsn asqslceivr lsrdqmlqiq nstepdplla
      241 tlekqeiieq llsnifhkek nesaivsaiq illtlletrr ptfeghieic ppgmshsacs
      301 vnksvleair grlgsfhell leppknmffk ytwnnflhtq veicialila spfentenat
      361 itdqdstgdn lllkhlfqkc qlierileaw emnekkqaeg grrhgymghl triancivhs
      421 tdkgpnsalv qqlikdlpde vrerwetfct sslgetnkrn tvdlafsdyq mqqmtsnfid
      481 qfgfndekfa dqddignvsf drvsdinftl ntnesgnial feacckeriq qfddggsdee
      541 diweekhiaf tpesqrrsss gstdseestd seeedgakqd lfepssante dkmevdlsep
      601 pnwsanfdvp metthgapld svgsdvwste epmptketgw asfseftssl stkdslrsns
      661 pvemetstep mdpltpsaaa lavqpeaags vameassdge edaestdkvt etvmnggmke
      721 tlsltvdakt etavfkseeg klstsqdaac kdaeecpeta eakcaaprpp ssspeqrtgq
      781 psapgdtsvn gpv
//
LOCUS       XP_054225263             601 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform
            X16 [Homo sapiens].
ACCESSION   XP_054225263
VERSION     XP_054225263.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369288.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..601
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..601
                     /product="serine/threonine-protein phosphatase 6
                     regulatory subunit 3 isoform X16"
                     /calculated_mol_wt=68769
     Region          128..513
                     /region_name="SAPS"
                     /note="SIT4 phosphatase-associated protein; pfam04499"
                     /db_xref="CDD:398279"
     CDS             1..601
                     /gene="PPP6R3"
                     /gene_synonym="C11orf23; PP6R3; SAP190; SAPL; SAPLa;
                     SAPS3"
                     /coded_by="XM_054369288.1:361..2166"
                     /db_xref="GeneID:55291"
                     /db_xref="HGNC:HGNC:1173"
                     /db_xref="MIM:610879"
ORIGIN      
        1 mfwkfdlhss shidtllere dvtlkelmde edvlqeckaq nrkliefllk aecledlvsf
       61 iieeppqdmd ekirykypni scelltsdvs qmndrlgede sllmklysfl lndsplnpll
      121 asffskvlsi lisrkpeqiv dflkkkhdfv dliikhigts aimdlllrll tcieppqprq
      181 dvlnwlneek iiqrlveivh psqeedrhsn asqslceivr lsrdqmlqiq nstepdplla
      241 tlekqeiieq llsnifhkek nesaivsaiq illtlletrr ptfeghieic ppgmshsacs
      301 vnksvleair grlgsfhell leppkksvmk ttwgvldppv gntrlnvirl issllqtnts
      361 singdlmeln sigvilnmff kytwnnflht qveicialil aspfentena titdqdstgd
      421 nlllkhlfqk cqlierilea wemnekkqae ggrrhgymgh ltriancivh stdkgpnsal
      481 vqqlikdlpd evrerwetfc tsslgetnkr ntvdlqgyih lytehfpvll avylrtcsll
      541 ldklcpapgs yhfcnilvkf slryskcfnl lapsypntct adsytpcvfm fgvydeqklv
      601 f
//
LOCUS       XP_054225264             601 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform
            X16 [Homo sapiens].
ACCESSION   XP_054225264
VERSION     XP_054225264.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369289.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..601
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..601
                     /product="serine/threonine-protein phosphatase 6
                     regulatory subunit 3 isoform X16"
                     /calculated_mol_wt=68769
     Region          128..513
                     /region_name="SAPS"
                     /note="SIT4 phosphatase-associated protein; pfam04499"
                     /db_xref="CDD:398279"
     CDS             1..601
                     /gene="PPP6R3"
                     /gene_synonym="C11orf23; PP6R3; SAP190; SAPL; SAPLa;
                     SAPS3"
                     /coded_by="XM_054369289.1:234..2039"
                     /db_xref="GeneID:55291"
                     /db_xref="HGNC:HGNC:1173"
                     /db_xref="MIM:610879"
ORIGIN      
        1 mfwkfdlhss shidtllere dvtlkelmde edvlqeckaq nrkliefllk aecledlvsf
       61 iieeppqdmd ekirykypni scelltsdvs qmndrlgede sllmklysfl lndsplnpll
      121 asffskvlsi lisrkpeqiv dflkkkhdfv dliikhigts aimdlllrll tcieppqprq
      181 dvlnwlneek iiqrlveivh psqeedrhsn asqslceivr lsrdqmlqiq nstepdplla
      241 tlekqeiieq llsnifhkek nesaivsaiq illtlletrr ptfeghieic ppgmshsacs
      301 vnksvleair grlgsfhell leppkksvmk ttwgvldppv gntrlnvirl issllqtnts
      361 singdlmeln sigvilnmff kytwnnflht qveicialil aspfentena titdqdstgd
      421 nlllkhlfqk cqlierilea wemnekkqae ggrrhgymgh ltriancivh stdkgpnsal
      481 vqqlikdlpd evrerwetfc tsslgetnkr ntvdlqgyih lytehfpvll avylrtcsll
      541 ldklcpapgs yhfcnilvkf slryskcfnl lapsypntct adsytpcvfm fgvydeqklv
      601 f
//
LOCUS       XP_054225265             601 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform
            X16 [Homo sapiens].
ACCESSION   XP_054225265
VERSION     XP_054225265.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369290.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..601
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..601
                     /product="serine/threonine-protein phosphatase 6
                     regulatory subunit 3 isoform X16"
                     /calculated_mol_wt=68769
     Region          128..513
                     /region_name="SAPS"
                     /note="SIT4 phosphatase-associated protein; pfam04499"
                     /db_xref="CDD:398279"
     CDS             1..601
                     /gene="PPP6R3"
                     /gene_synonym="C11orf23; PP6R3; SAP190; SAPL; SAPLa;
                     SAPS3"
                     /coded_by="XM_054369290.1:339..2144"
                     /db_xref="GeneID:55291"
                     /db_xref="HGNC:HGNC:1173"
                     /db_xref="MIM:610879"
ORIGIN      
        1 mfwkfdlhss shidtllere dvtlkelmde edvlqeckaq nrkliefllk aecledlvsf
       61 iieeppqdmd ekirykypni scelltsdvs qmndrlgede sllmklysfl lndsplnpll
      121 asffskvlsi lisrkpeqiv dflkkkhdfv dliikhigts aimdlllrll tcieppqprq
      181 dvlnwlneek iiqrlveivh psqeedrhsn asqslceivr lsrdqmlqiq nstepdplla
      241 tlekqeiieq llsnifhkek nesaivsaiq illtlletrr ptfeghieic ppgmshsacs
      301 vnksvleair grlgsfhell leppkksvmk ttwgvldppv gntrlnvirl issllqtnts
      361 singdlmeln sigvilnmff kytwnnflht qveicialil aspfentena titdqdstgd
      421 nlllkhlfqk cqlierilea wemnekkqae ggrrhgymgh ltriancivh stdkgpnsal
      481 vqqlikdlpd evrerwetfc tsslgetnkr ntvdlqgyih lytehfpvll avylrtcsll
      541 ldklcpapgs yhfcnilvkf slryskcfnl lapsypntct adsytpcvfm fgvydeqklv
      601 f
//
LOCUS       XP_054225266             246 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin ligase RNF121 isoform X3 [Homo sapiens].
ACCESSION   XP_054225266
VERSION     XP_054225266.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369291.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..246
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..246
                     /product="E3 ubiquitin ligase RNF121 isoform X3"
                     /calculated_mol_wt=28605
     Region          143..197
                     /region_name="RING-H2_RNF121-like"
                     /note="RING finger, H2 subclass, found in RING finger
                     proteins RNF121, RNF175 and similar proteins; cd16475"
                     /db_xref="CDD:438138"
     CDS             1..246
                     /gene="RNF121"
                     /coded_by="XM_054369291.1:146..886"
                     /db_xref="GeneID:55298"
                     /db_xref="HGNC:HGNC:21070"
                     /db_xref="MIM:620529"
ORIGIN      
        1 mvtlfqmwvv plyftvklhw wrflviwilf savtafvtfr atrkplvqtt prlvykwfll
       61 iykisyatgi vgymavmftl fglnllfkik pedamdfgis llfyglyygv lerdfaemca
      121 dymastigfy sesgmptkhl sdsvcavcgq qifvdvseeg iientyrlsc nhvfhefcir
      181 gwcivgkkqt cpyckekvdl krmfsnpwer phvmygqlld wlrylvawqp viigvvqgin
      241 yilgle
//
LOCUS       XP_054225267             220 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin ligase RNF121 isoform X4 [Homo sapiens].
ACCESSION   XP_054225267
VERSION     XP_054225267.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369292.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..220
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..220
                     /product="E3 ubiquitin ligase RNF121 isoform X4"
                     /calculated_mol_wt=24863
     Region          117..171
                     /region_name="RING-H2_RNF121-like"
                     /note="RING finger, H2 subclass, found in RING finger
                     proteins RNF121, RNF175 and similar proteins; cd16475"
                     /db_xref="CDD:438138"
     CDS             1..220
                     /gene="RNF121"
                     /coded_by="XM_054369292.1:75..737"
                     /db_xref="GeneID:55298"
                     /db_xref="HGNC:HGNC:21070"
                     /db_xref="MIM:620529"
ORIGIN      
        1 mrlicqislq ksnggsstha cmpstvamkl cmlkwsssss qpwwwpscsw csgsrgthap
       61 tmikpedamd fgisllfygl yygvlerdfa emcadymast igfysesgmp tkhlsdsvca
      121 vcgqqifvdv seegiienty rlscnhvfhe fcirgwcivg kkqtcpycke kvdlkrmfsn
      181 pwerphvmyg qlldwlrylv awqpviigvv qginyilgle
//
LOCUS       XP_054225268             233 aa            linear   PRI 05-AUG-2025
DEFINITION  alkaline ceramidase 3 isoform X1 [Homo sapiens].
ACCESSION   XP_054225268
VERSION     XP_054225268.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369293.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..233
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..233
                     /product="alkaline ceramidase 3 isoform X1"
                     /calculated_mol_wt=27428
     Region          12..229
                     /region_name="Ceramidase"
                     /note="pfam05875"
                     /db_xref="CDD:461766"
     CDS             1..233
                     /gene="ACER3"
                     /gene_synonym="APHC; PHCA; PLDECO"
                     /coded_by="XM_054369293.1:60..761"
                     /db_xref="GeneID:55331"
                     /db_xref="HGNC:HGNC:16066"
                     /db_xref="MIM:617036"
ORIGIN      
        1 mapaadregy wgpttstldw ceenysvtwy iaefwntvsn limiippmfg aiqsvrdgle
       61 kryiasylal tvvgmgswcf hmtlkyemql ldelpmiysc cifvycmfec fkiknsvnyh
      121 llftlvlfsl ivttvylkvk epifhqvmyg mlvftlvlrs iyivtwnfrk kvppiigitt
      181 qfhawwhilt glgsylhilf slytrtlylr yrpkvkflfg iwpvilfepl rkh
//
LOCUS       XP_054225269             225 aa            linear   PRI 05-AUG-2025
DEFINITION  alkaline ceramidase 3 isoform X2 [Homo sapiens].
ACCESSION   XP_054225269
VERSION     XP_054225269.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369294.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..225
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..225
                     /product="alkaline ceramidase 3 isoform X2"
                     /calculated_mol_wt=26563
     Region          1..221
                     /region_name="Ceramidase"
                     /note="pfam05875"
                     /db_xref="CDD:461766"
     CDS             1..225
                     /gene="ACER3"
                     /gene_synonym="APHC; PHCA; PLDECO"
                     /coded_by="XM_054369294.1:178..855"
                     /db_xref="GeneID:55331"
                     /db_xref="HGNC:HGNC:16066"
                     /db_xref="MIM:617036"
ORIGIN      
        1 miippmfgai qsvrdglekr yiasylaltv vgmgswcfhm tlkyemqlld elpmiyscci
       61 fvycmfecfk iknsvnyhll ftlvlfsliv ttvylkvkep ifhqvmygml vftlvlrsiy
      121 ivtwvypwlr glgytslgif llgflfwnid nifceslrnf rkkvppiigi ttqfhawwhi
      181 ltglgsylhi lfslytrtly lryrpkvkfl fgiwpvilfe plrkh
//
LOCUS       XP_054225270             170 aa            linear   PRI 05-AUG-2025
DEFINITION  alkaline ceramidase 3 isoform X3 [Homo sapiens].
ACCESSION   XP_054225270
VERSION     XP_054225270.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369295.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..170
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..170
                     /product="alkaline ceramidase 3 isoform X3"
                     /calculated_mol_wt=19566
     Region          12..>146
                     /region_name="Ceramidase"
                     /note="pfam05875"
                     /db_xref="CDD:461766"
     CDS             1..170
                     /gene="ACER3"
                     /gene_synonym="APHC; PHCA; PLDECO"
                     /coded_by="XM_054369295.1:60..572"
                     /db_xref="GeneID:55331"
                     /db_xref="HGNC:HGNC:16066"
                     /db_xref="MIM:617036"
ORIGIN      
        1 mapaadregy wgpttstldw ceenysvtwy iaefwntvsn limiippmfg aiqsvrdgle
       61 kryiasylal tvvgmgswcf hmtlkyemql ldelpmiysc cifvycmfec fkiknsvnyh
      121 llftlvlfsl ivttvylkvk epifhqeshs vtpaevqwhn lgsleppppr
//
LOCUS       XP_054225271             165 aa            linear   PRI 05-AUG-2025
DEFINITION  alkaline ceramidase 3 isoform X4 [Homo sapiens].
ACCESSION   XP_054225271
VERSION     XP_054225271.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369296.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..165
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..165
                     /product="alkaline ceramidase 3 isoform X4"
                     /calculated_mol_wt=19120
     Region          12..>164
                     /region_name="Ceramidase"
                     /note="pfam05875"
                     /db_xref="CDD:461766"
     CDS             1..165
                     /gene="ACER3"
                     /gene_synonym="APHC; PHCA; PLDECO"
                     /coded_by="XM_054369296.1:60..557"
                     /db_xref="GeneID:55331"
                     /db_xref="HGNC:HGNC:16066"
                     /db_xref="MIM:617036"
ORIGIN      
        1 mapaadregy wgpttstldw ceenysvtwy iaefwntvsn limiippmfg aiqsvrdgle
       61 kryiasylal tvvgmgswcf hmtlkyemql ldelpmiysc cifvycmfec fkiknsvnyh
      121 llftlvlfsl ivttvylkvk epifhqvmyg mlvftlvlrs iyivt
//
LOCUS       XP_054225272             195 aa            linear   PRI 05-AUG-2025
DEFINITION  GDP-fucose transporter 1 isoform X1 [Homo sapiens].
ACCESSION   XP_054225272
VERSION     XP_054225272.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369297.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..195
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..195
                     /product="GDP-fucose transporter 1 isoform X1"
                     /calculated_mol_wt=21162
     CDS             1..195
                     /gene="SLC35C1"
                     /gene_synonym="CDG2C; FUCT1"
                     /coded_by="XM_054369297.1:408..995"
                     /db_xref="GeneID:55343"
                     /db_xref="HGNC:HGNC:20197"
                     /db_xref="MIM:605881"
ORIGIN      
        1 mlqllldseg gfwlgvdqeg aegtlswlgt vfgvlaslcv slnaiyttkv lpavdgsiwr
       61 ltfynnvnac ilflplllll gelqalrdfa qlgsahfwgm mtlgglfgfa igyvtglqik
      121 ftsplthnvs gtakacaqtv lavlyyeetk sflwwtsnmm vlggssaytw vrgwemkktp
      181 eepspkdsek samgv
//
LOCUS       XP_054225273             192 aa            linear   PRI 05-AUG-2025
DEFINITION  GDP-fucose transporter 1 isoform X2 [Homo sapiens].
ACCESSION   XP_054225273
VERSION     XP_054225273.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369298.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..192
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..192
                     /product="GDP-fucose transporter 1 isoform X2"
                     /calculated_mol_wt=20845
     Region          39..>179
                     /region_name="TPT"
                     /note="Triose-phosphate Transporter family; cl26744"
                     /db_xref="CDD:474852"
     CDS             1..192
                     /gene="SLC35C1"
                     /gene_synonym="CDG2C; FUCT1"
                     /coded_by="XM_054369298.1:654..1232"
                     /db_xref="GeneID:55343"
                     /db_xref="HGNC:HGNC:20197"
                     /db_xref="MIM:605881"
ORIGIN      
        1 mnraplkrsr ilhmaltgas dpsaeaeang ekpfllralq ialvvslywv tsismvflnk
       61 ylldspslrl dtpifvtfyq clvttllckg lsalaaccpg avdfpslrld lrvarsvlpl
      121 svvfigmitf nnlclkyvgv afynvgrslt tvfnvllsyl llkqttsfya lltcgiiige
      181 desqatilgl ps
//
LOCUS       XP_054225274             514 aa            linear   PRI 05-AUG-2025
DEFINITION  T-complex protein 11-like protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_054225274
VERSION     XP_054225274.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369299.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..514
                     /product="T-complex protein 11-like protein 1 isoform X1"
                     /calculated_mol_wt=57543
     Region          78..507
                     /region_name="Tcp11"
                     /note="T-complex protein 11; pfam05794"
                     /db_xref="CDD:461743"
     CDS             1..514
                     /gene="TCP11L1"
                     /gene_synonym="dJ85M6.3"
                     /coded_by="XM_054369299.1:246..1790"
                     /db_xref="GeneID:55346"
                     /db_xref="HGNC:HGNC:25655"
ORIGIN      
        1 msenldksnv neagksksnd seegledave gadealqkai ksdssspqrv qrphsspprf
       61 vtveelleta rgvtnmalah eivvngdfqi kpvelpensl kkrvkeivhk afwdclsvql
      121 sedppaydha iklvgeiket llsfllpght rlrnqitevl dldlikqeae ngaldisrla
      181 efiigmmgtl capardeevk klkdikeivp lfreifsvld lmkvdmanfa issirphlmq
      241 qsveyerkkf qeilerqptl fftdsldfvt qwleeasedl mtqkykhalp vggmaagsgd
      301 mprlspvavq nyaylkllkw dhlqrpfpet vlmdqsrfhe lqlqleqlti lgavllvtfs
      361 maapgissqa dfaeklkmiv killtdmhlp sfhlkdvltt igekvclevs sclslcgssp
      421 fttdketvlk gqiqavaspd dpirrimesr iltfletyla sghqkplptv pgglspvqre
      481 leevaikfar lvnynkmvfc pyydailski lvrs
//
LOCUS       XP_054225275             514 aa            linear   PRI 05-AUG-2025
DEFINITION  T-complex protein 11-like protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_054225275
VERSION     XP_054225275.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369300.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..514
                     /product="T-complex protein 11-like protein 1 isoform X1"
                     /calculated_mol_wt=57543
     Region          78..507
                     /region_name="Tcp11"
                     /note="T-complex protein 11; pfam05794"
                     /db_xref="CDD:461743"
     CDS             1..514
                     /gene="TCP11L1"
                     /gene_synonym="dJ85M6.3"
                     /coded_by="XM_054369300.1:470..2014"
                     /db_xref="GeneID:55346"
                     /db_xref="HGNC:HGNC:25655"
ORIGIN      
        1 msenldksnv neagksksnd seegledave gadealqkai ksdssspqrv qrphsspprf
       61 vtveelleta rgvtnmalah eivvngdfqi kpvelpensl kkrvkeivhk afwdclsvql
      121 sedppaydha iklvgeiket llsfllpght rlrnqitevl dldlikqeae ngaldisrla
      181 efiigmmgtl capardeevk klkdikeivp lfreifsvld lmkvdmanfa issirphlmq
      241 qsveyerkkf qeilerqptl fftdsldfvt qwleeasedl mtqkykhalp vggmaagsgd
      301 mprlspvavq nyaylkllkw dhlqrpfpet vlmdqsrfhe lqlqleqlti lgavllvtfs
      361 maapgissqa dfaeklkmiv killtdmhlp sfhlkdvltt igekvclevs sclslcgssp
      421 fttdketvlk gqiqavaspd dpirrimesr iltfletyla sghqkplptv pgglspvqre
      481 leevaikfar lvnynkmvfc pyydailski lvrs
//
LOCUS       XP_054225276             514 aa            linear   PRI 05-AUG-2025
DEFINITION  T-complex protein 11-like protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_054225276
VERSION     XP_054225276.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369301.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..514
                     /product="T-complex protein 11-like protein 1 isoform X1"
                     /calculated_mol_wt=57543
     Region          78..507
                     /region_name="Tcp11"
                     /note="T-complex protein 11; pfam05794"
                     /db_xref="CDD:461743"
     CDS             1..514
                     /gene="TCP11L1"
                     /gene_synonym="dJ85M6.3"
                     /coded_by="XM_054369301.1:285..1829"
                     /db_xref="GeneID:55346"
                     /db_xref="HGNC:HGNC:25655"
ORIGIN      
        1 msenldksnv neagksksnd seegledave gadealqkai ksdssspqrv qrphsspprf
       61 vtveelleta rgvtnmalah eivvngdfqi kpvelpensl kkrvkeivhk afwdclsvql
      121 sedppaydha iklvgeiket llsfllpght rlrnqitevl dldlikqeae ngaldisrla
      181 efiigmmgtl capardeevk klkdikeivp lfreifsvld lmkvdmanfa issirphlmq
      241 qsveyerkkf qeilerqptl fftdsldfvt qwleeasedl mtqkykhalp vggmaagsgd
      301 mprlspvavq nyaylkllkw dhlqrpfpet vlmdqsrfhe lqlqleqlti lgavllvtfs
      361 maapgissqa dfaeklkmiv killtdmhlp sfhlkdvltt igekvclevs sclslcgssp
      421 fttdketvlk gqiqavaspd dpirrimesr iltfletyla sghqkplptv pgglspvqre
      481 leevaikfar lvnynkmvfc pyydailski lvrs
//
LOCUS       XP_054225277             514 aa            linear   PRI 05-AUG-2025
DEFINITION  T-complex protein 11-like protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_054225277
VERSION     XP_054225277.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369302.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..514
                     /product="T-complex protein 11-like protein 1 isoform X1"
                     /calculated_mol_wt=57543
     Region          78..507
                     /region_name="Tcp11"
                     /note="T-complex protein 11; pfam05794"
                     /db_xref="CDD:461743"
     CDS             1..514
                     /gene="TCP11L1"
                     /gene_synonym="dJ85M6.3"
                     /coded_by="XM_054369302.1:216..1760"
                     /db_xref="GeneID:55346"
                     /db_xref="HGNC:HGNC:25655"
ORIGIN      
        1 msenldksnv neagksksnd seegledave gadealqkai ksdssspqrv qrphsspprf
       61 vtveelleta rgvtnmalah eivvngdfqi kpvelpensl kkrvkeivhk afwdclsvql
      121 sedppaydha iklvgeiket llsfllpght rlrnqitevl dldlikqeae ngaldisrla
      181 efiigmmgtl capardeevk klkdikeivp lfreifsvld lmkvdmanfa issirphlmq
      241 qsveyerkkf qeilerqptl fftdsldfvt qwleeasedl mtqkykhalp vggmaagsgd
      301 mprlspvavq nyaylkllkw dhlqrpfpet vlmdqsrfhe lqlqleqlti lgavllvtfs
      361 maapgissqa dfaeklkmiv killtdmhlp sfhlkdvltt igekvclevs sclslcgssp
      421 fttdketvlk gqiqavaspd dpirrimesr iltfletyla sghqkplptv pgglspvqre
      481 leevaikfar lvnynkmvfc pyydailski lvrs
//
LOCUS       XP_054225278             509 aa            linear   PRI 05-AUG-2025
DEFINITION  T-complex protein 11-like protein 1 isoform X2 [Homo sapiens].
ACCESSION   XP_054225278
VERSION     XP_054225278.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369303.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..509
                     /product="T-complex protein 11-like protein 1 isoform X2"
                     /calculated_mol_wt=56932
     Region          78..502
                     /region_name="Tcp11"
                     /note="T-complex protein 11; pfam05794"
                     /db_xref="CDD:461743"
     CDS             1..509
                     /gene="TCP11L1"
                     /gene_synonym="dJ85M6.3"
                     /coded_by="XM_054369303.1:431..1960"
                     /db_xref="GeneID:55346"
                     /db_xref="HGNC:HGNC:25655"
ORIGIN      
        1 msenldksnv neagksksnd seegledave gadealqkai ksdssspqrv qrphsspprf
       61 vtveelleta rgvtnmalah eivvngdfqi kpvelpensl kkrvkeivhk afwdclsvql
      121 sedppaydha iklvgeiket llsfllpght rlrnqitevl dldlikqeae ngaldisrla
      181 efiigmmgtl capardeevk klkdikeivp lfreifsvld lmkvdmanfa issirphlmq
      241 qsveyerkkf qeilerqpns ldfvtqwlee asedlmtqky khalpvggma agsgdmprls
      301 pvavqnyayl kllkwdhlqr pfpetvlmdq srfhelqlql eqltilgavl lvtfsmaapg
      361 issqadfaek lkmivkillt dmhlpsfhlk dvlttigekv clevssclsl cgsspfttdk
      421 etvlkgqiqa vaspddpirr imesriltfl etylasghqk plptvpggls pvqreleeva
      481 ikfarlvnyn kmvfcpyyda ilskilvrs
//
LOCUS       XP_054225279             509 aa            linear   PRI 05-AUG-2025
DEFINITION  T-complex protein 11-like protein 1 isoform X2 [Homo sapiens].
ACCESSION   XP_054225279
VERSION     XP_054225279.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369304.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..509
                     /product="T-complex protein 11-like protein 1 isoform X2"
                     /calculated_mol_wt=56932
     Region          78..502
                     /region_name="Tcp11"
                     /note="T-complex protein 11; pfam05794"
                     /db_xref="CDD:461743"
     CDS             1..509
                     /gene="TCP11L1"
                     /gene_synonym="dJ85M6.3"
                     /coded_by="XM_054369304.1:617..2146"
                     /db_xref="GeneID:55346"
                     /db_xref="HGNC:HGNC:25655"
ORIGIN      
        1 msenldksnv neagksksnd seegledave gadealqkai ksdssspqrv qrphsspprf
       61 vtveelleta rgvtnmalah eivvngdfqi kpvelpensl kkrvkeivhk afwdclsvql
      121 sedppaydha iklvgeiket llsfllpght rlrnqitevl dldlikqeae ngaldisrla
      181 efiigmmgtl capardeevk klkdikeivp lfreifsvld lmkvdmanfa issirphlmq
      241 qsveyerkkf qeilerqpns ldfvtqwlee asedlmtqky khalpvggma agsgdmprls
      301 pvavqnyayl kllkwdhlqr pfpetvlmdq srfhelqlql eqltilgavl lvtfsmaapg
      361 issqadfaek lkmivkillt dmhlpsfhlk dvlttigekv clevssclsl cgsspfttdk
      421 etvlkgqiqa vaspddpirr imesriltfl etylasghqk plptvpggls pvqreleeva
      481 ikfarlvnyn kmvfcpyyda ilskilvrs
//
LOCUS       XP_054225280             439 aa            linear   PRI 05-AUG-2025
DEFINITION  T-complex protein 11-like protein 1 isoform X5 [Homo sapiens].
ACCESSION   XP_054225280
VERSION     XP_054225280.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369305.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..439
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..439
                     /product="T-complex protein 11-like protein 1 isoform X5"
                     /calculated_mol_wt=49462
     Region          3..432
                     /region_name="Tcp11"
                     /note="T-complex protein 11; pfam05794"
                     /db_xref="CDD:461743"
     CDS             1..439
                     /gene="TCP11L1"
                     /gene_synonym="dJ85M6.3"
                     /coded_by="XM_054369305.1:148..1467"
                     /db_xref="GeneID:55346"
                     /db_xref="HGNC:HGNC:25655"
ORIGIN      
        1 malaheivvn gdfqikpvel penslkkrvk eivhkafwdc lsvqlsedpp aydhaiklvg
       61 eiketllsfl lpghtrlrnq itevldldli kqeaengald isrlaefiig mmgtlcapar
      121 deevkklkdi keivplfrei fsvldlmkvd manfaissir phlmqqsvey erkkfqeile
      181 rqptlfftds ldfvtqwlee asedlmtqky khalpvggma agsgdmprls pvavqnyayl
      241 kllkwdhlqr pfpetvlmdq srfhelqlql eqltilgavl lvtfsmaapg issqadfaek
      301 lkmivkillt dmhlpsfhlk dvlttigekv clevssclsl cgsspfttdk etvlkgqiqa
      361 vaspddpirr imesriltfl etylasghqk plptvpggls pvqreleeva ikfarlvnyn
      421 kmvfcpyyda ilskilvrs
//
LOCUS       XP_054225281             329 aa            linear   PRI 05-AUG-2025
DEFINITION  T-complex protein 11-like protein 1 isoform X3 [Homo sapiens].
ACCESSION   XP_054225281
VERSION     XP_054225281.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369306.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..329
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..329
                     /product="T-complex protein 11-like protein 1 isoform X3"
                     /calculated_mol_wt=37083
     Region          <1..322
                     /region_name="Tcp11"
                     /note="T-complex protein 11; pfam05794"
                     /db_xref="CDD:461743"
     CDS             1..329
                     /gene="TCP11L1"
                     /gene_synonym="dJ85M6.3"
                     /coded_by="XM_054369306.1:335..1324"
                     /db_xref="GeneID:55346"
                     /db_xref="HGNC:HGNC:25655"
ORIGIN      
        1 mmgtlcapar deevkklkdi keivplfrei fsvldlmkvd manfaissir phlmqqsvey
       61 erkkfqeile rqptlfftds ldfvtqwlee asedlmtqky khalpvggma agsgdmprls
      121 pvavqnyayl kllkwdhlqr pfpetvlmdq srfhelqlql eqltilgavl lvtfsmaapg
      181 issqadfaek lkmivkillt dmhlpsfhlk dvlttigekv clevssclsl cgsspfttdk
      241 etvlkgqiqa vaspddpirr imesriltfl etylasghqk plptvpggls pvqreleeva
      301 ikfarlvnyn kmvfcpyyda ilskilvrs
//
LOCUS       XP_054225282             302 aa            linear   PRI 05-AUG-2025
DEFINITION  T-complex protein 11-like protein 1 isoform X4 [Homo sapiens].
ACCESSION   XP_054225282
VERSION     XP_054225282.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369307.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..302
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..302
                     /product="T-complex protein 11-like protein 1 isoform X4"
                     /calculated_mol_wt=33374
     Region          78..>262
                     /region_name="Tcp11"
                     /note="T-complex protein 11; pfam05794"
                     /db_xref="CDD:461743"
     CDS             1..302
                     /gene="TCP11L1"
                     /gene_synonym="dJ85M6.3"
                     /coded_by="XM_054369307.1:246..1154"
                     /db_xref="GeneID:55346"
                     /db_xref="HGNC:HGNC:25655"
ORIGIN      
        1 msenldksnv neagksksnd seegledave gadealqkai ksdssspqrv qrphsspprf
       61 vtveelleta rgvtnmalah eivvngdfqi kpvelpensl kkrvkeivhk afwdclsvql
      121 sedppaydha iklvgeiket llsfllpght rlrnqitevl dldlikqeae ngaldisrla
      181 efiigmmgtl capardeevk klkdikeivp lfreifsvld lmkvdmanfa issirphlmq
      241 qsveyerkkf qeilerqpns fngpvslpra pvaagttdhp ggcvaghlqh gsarnfqpgr
      301 lc
//
LOCUS       XP_054225283             917 aa            linear   PRI 05-AUG-2025
DEFINITION  p53-induced death domain-containing protein 1 isoform X14 [Homo
            sapiens].
ACCESSION   XP_054225283
VERSION     XP_054225283.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369308.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..917
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..917
                     /product="p53-induced death domain-containing protein 1
                     isoform X14"
                     /calculated_mol_wt=100150
     Region          39..63
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          64..91
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          <87..>296
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          127..152
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          153..172
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          173..195
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          196..218
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          219..241
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          242..264
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          265..286
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          325..416
                     /region_name="ZU5"
                     /note="ZU5 domain; cl02517"
                     /db_xref="CDD:470600"
     Region          421..453
                     /region_name="Peptidase_S68"
                     /note="Peptidase S68; pfam10461"
                     /db_xref="CDD:463098"
     Region          465..537
                     /region_name="ZU5"
                     /note="ZU5 domain; cl02517"
                     /db_xref="CDD:470600"
     Region          795..880
                     /region_name="Death_PIDD"
                     /note="Death Domain of p53-induced protein with a death
                     domain; cd08779"
                     /db_xref="CDD:260049"
     Site            order(803..804,806,808,833..836,839)
                     /site_type="other"
                     /note="Type III interaction site [polypeptide binding]"
                     /db_xref="CDD:260049"
     Site            order(808,812,815..817,820..821,828,866,868..871,874)
                     /site_type="other"
                     /note="PIDD-RAIDD interaction site [polypeptide binding]"
                     /db_xref="CDD:260049"
     Site            order(808,812,815..816,820..821,828,866..867)
                     /site_type="other"
                     /note="Type I interaction site [polypeptide binding]"
                     /db_xref="CDD:260049"
     Site            order(868..871,874)
                     /site_type="other"
                     /note="Type II interaction site [polypeptide binding]"
                     /db_xref="CDD:260049"
     CDS             1..917
                     /gene="PIDD1"
                     /gene_synonym="LRDD; MRT75; PIDD"
                     /coded_by="XM_054369308.1:76..2829"
                     /db_xref="GeneID:55367"
                     /db_xref="HGNC:HGNC:16491"
                     /db_xref="MIM:605247"
ORIGIN      
        1 maatvegpel eaaaaagdas edsdagsral pflggnrlsl dlypggcqql lhlcvqqplq
       61 llqveflrls thedpqllea tlaqlpqsls clrslvlkgg qrrdtlgacl rgaltnlpag
      121 lsglahlahl dlsfnsletl pacvlqmrgl galllshncl selpealgal paltfltvth
      181 nrlqtlppal galstlqrld lsqnlldtlp peigglgsll elnlasnrlq slpaslaglr
      241 slrllvlhsn llasvpadla rlplltrldl rdnqlrdlpp elldapfvrl qgnplgeasp
      301 dapsspvaal ipemprlflt sdldsfpvtp rgcsvtlacg vrlqfpagat atpitiryrl
      361 llpepglvpl gphdallshv lelqphgvaf qqdvglwllf tppqarrcre vvvrtrndns
      421 wgdletylee eapqrlwahc qvphfswflv vsrpvsnacl vppegtllcs sghpgvkvif
      481 ppgateeprr vsmqvvrmag relqallgep eaavspllcl sqsgppsflq pvtvqlplps
      541 gitglsldrs rlhllywapp aatwdditaq vvlelthlya rfqvthfsws vppsflsppp
      601 pvctalltps sprywlwytt kncvgglark awerlrlhrv nlialqrrrd peqvllqclp
      661 rnkvdatlrr lleryrgpep sdtvemfege effaafergi dvdadrpdcv egricfvfys
      721 hlknvkevsf yrgavpvrvp eeaeaarqrk gadalwmatl piklprlrgs egprrgagls
      781 laplnlgdae tgfltqsnll svagrlgldw pavalhlgvs yrevqrirhe frddldeqir
      841 hmlfswaerq agqpgavgll vqaleqsdrq dvaeevravl elgrrkyqds irrmglapkd
      901 palpgssapq ppepaqa
//
LOCUS       XP_054225284             937 aa            linear   PRI 05-AUG-2025
DEFINITION  p53-induced death domain-containing protein 1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225284
VERSION     XP_054225284.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369309.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..937
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..937
                     /product="p53-induced death domain-containing protein 1
                     isoform X1"
                     /calculated_mol_wt=102562
     Region          66..90
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          91..118
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          <114..>323
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          154..179
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          180..199
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          200..222
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          223..245
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          246..268
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          269..291
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          292..313
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          352..443
                     /region_name="ZU5"
                     /note="ZU5 domain; cl02517"
                     /db_xref="CDD:470600"
     Region          448..480
                     /region_name="Peptidase_S68"
                     /note="Peptidase S68; pfam10461"
                     /db_xref="CDD:463098"
     Region          492..564
                     /region_name="ZU5"
                     /note="ZU5 domain; cl02517"
                     /db_xref="CDD:470600"
     Region          815..900
                     /region_name="Death_PIDD"
                     /note="Death Domain of p53-induced protein with a death
                     domain; cd08779"
                     /db_xref="CDD:260049"
     Site            order(823..824,826,828,853..856,859)
                     /site_type="other"
                     /note="Type III interaction site [polypeptide binding]"
                     /db_xref="CDD:260049"
     Site            order(828,832,835..837,840..841,848,886,888..891,894)
                     /site_type="other"
                     /note="PIDD-RAIDD interaction site [polypeptide binding]"
                     /db_xref="CDD:260049"
     Site            order(828,832,835..836,840..841,848,886..887)
                     /site_type="other"
                     /note="Type I interaction site [polypeptide binding]"
                     /db_xref="CDD:260049"
     Site            order(888..891,894)
                     /site_type="other"
                     /note="Type II interaction site [polypeptide binding]"
                     /db_xref="CDD:260049"
     CDS             1..937
                     /gene="PIDD1"
                     /gene_synonym="LRDD; MRT75; PIDD"
                     /coded_by="XM_054369309.1:836..3649"
                     /db_xref="GeneID:55367"
                     /db_xref="HGNC:HGNC:16491"
                     /db_xref="MIM:605247"
ORIGIN      
        1 mqlpralpgq aclragtcla skdrrwamaa tvegpeleaa aaagdaseds dagsralpfl
       61 ggnrlsldly pggcqqllhl cvqqplqllq veflrlsthe dpqlleatla qlpqslsclr
      121 slvlkggqrr dtlgaclrga ltnlpaglsg lahlahldls fnsletlpac vlqmrglgal
      181 llshnclsel pealgalpal tfltvthnrl qtlppalgal stlqrldlsq nlldtlppei
      241 gglgslleln lasnrlqslp aslaglrslr llvlhsnlla svpadlarlp lltrldlrdn
      301 qlrdlppell dapfvrlqgn plgeaspdap sspvaalipe mprlfltsdl dsfpvtprgc
      361 svtlacgvrl qfpagatatp itiryrlllp epglvplgph dallshvlel qphgvafqqd
      421 vglwllftpp qarrcrevvv rtrndnswgd letyleeeap qrlwahcqvp hfswflvvsr
      481 pvsnaclvpp egtllcssgh pgvkvifppg ateeprrvsm qvvrmagrel qallgepeaa
      541 vspllclsqs gppsflqpvt vqlplpsgit glsldrsrlh llywappaat wdditaqvvl
      601 elthlyarfq vthfswywlw yttkncvggl arkawerlrl hrvnlialqr rrdpeqvllq
      661 clprnkvdat lrrlleryrg pepsdtvemf egeeffaafe rgidvdadrp dcvegricfv
      721 fyshlknvke vyvtttldre aqavrgqvsf yrgavpvrvp eeaeaarqrk gadalwmatl
      781 piklprlrgs egprrgagls laplnlgdae tgfltqsnll svagrlgldw pavalhlgvs
      841 yrevqrirhe frddldeqir hmlfswaerq agqpgavgll vqaleqsdrq dvaeevravl
      901 elgrrkyqds irrmglapkd palpgssapq ppepaqa
//
LOCUS       XP_054225285             934 aa            linear   PRI 05-AUG-2025
DEFINITION  p53-induced death domain-containing protein 1 isoform X2 [Homo
            sapiens].
ACCESSION   XP_054225285
VERSION     XP_054225285.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369310.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..934
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..934
                     /product="p53-induced death domain-containing protein 1
                     isoform X2"
                     /calculated_mol_wt=102039
     Region          39..63
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          64..91
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          <87..>296
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          127..152
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          153..172
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          173..195
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          196..218
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          219..241
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          242..264
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          265..286
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          325..416
                     /region_name="ZU5"
                     /note="ZU5 domain; cl02517"
                     /db_xref="CDD:470600"
     Region          421..453
                     /region_name="Peptidase_S68"
                     /note="Peptidase S68; pfam10461"
                     /db_xref="CDD:463098"
     Region          465..537
                     /region_name="ZU5"
                     /note="ZU5 domain; cl02517"
                     /db_xref="CDD:470600"
     Region          812..897
                     /region_name="Death_PIDD"
                     /note="Death Domain of p53-induced protein with a death
                     domain; cd08779"
                     /db_xref="CDD:260049"
     Site            order(820..821,823,825,850..853,856)
                     /site_type="other"
                     /note="Type III interaction site [polypeptide binding]"
                     /db_xref="CDD:260049"
     Site            order(825,829,832..834,837..838,845,883,885..888,891)
                     /site_type="other"
                     /note="PIDD-RAIDD interaction site [polypeptide binding]"
                     /db_xref="CDD:260049"
     Site            order(825,829,832..833,837..838,845,883..884)
                     /site_type="other"
                     /note="Type I interaction site [polypeptide binding]"
                     /db_xref="CDD:260049"
     Site            order(885..888,891)
                     /site_type="other"
                     /note="Type II interaction site [polypeptide binding]"
                     /db_xref="CDD:260049"
     CDS             1..934
                     /gene="PIDD1"
                     /gene_synonym="LRDD; MRT75; PIDD"
                     /coded_by="XM_054369310.1:1370..4174"
                     /db_xref="GeneID:55367"
                     /db_xref="HGNC:HGNC:16491"
                     /db_xref="MIM:605247"
ORIGIN      
        1 maatvegpel eaaaaagdas edsdagsral pflggnrlsl dlypggcqql lhlcvqqplq
       61 llqveflrls thedpqllea tlaqlpqsls clrslvlkgg qrrdtlgacl rgaltnlpag
      121 lsglahlahl dlsfnsletl pacvlqmrgl galllshncl selpealgal paltfltvth
      181 nrlqtlppal galstlqrld lsqnlldtlp peigglgsll elnlasnrlq slpaslaglr
      241 slrllvlhsn llasvpadla rlplltrldl rdnqlrdlpp elldapfvrl qgnplgeasp
      301 dapsspvaal ipemprlflt sdldsfpvtp rgcsvtlacg vrlqfpagat atpitiryrl
      361 llpepglvpl gphdallshv lelqphgvaf qqdvglwllf tppqarrcre vvvrtrndns
      421 wgdletylee eapqrlwahc qvphfswflv vsrpvsnacl vppegtllcs sghpgvkvif
      481 ppgateeprr vsmqvvrmag relqallgep eaavspllcl sqsgppsflq pvtvqlplps
      541 gitglsldrs rlhllywapp aatwdditaq vvlelthlya rfqvthfsws vppsflsppp
      601 pvctalltps sprywlwytt kncvgglark awerlrlhrv nlialqrrrd peqvllqclp
      661 rnkvdatlrr lleryrgpep sdtvemfege effaafergi dvdadrpdcv egricfvfys
      721 hlknvkevyv tttldreaqa vrgqvsfyrg avpvrvpeea eaarqrkgad alwmatlpik
      781 lprlrgsegp rrgaglslap lnlgdaetgf ltqsnllsva grlgldwpav alhlgvsyre
      841 vqrirhefrd dldeqirhml fswaerqagq pgavgllvqa leqsdrqdva eevravlelg
      901 rrkyqdsirr mglapkdpal pgssapqppe paqa
//
LOCUS       XP_054225286             920 aa            linear   PRI 05-AUG-2025
DEFINITION  p53-induced death domain-containing protein 1 isoform X3 [Homo
            sapiens].
ACCESSION   XP_054225286
VERSION     XP_054225286.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369311.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..920
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..920
                     /product="p53-induced death domain-containing protein 1
                     isoform X3"
                     /calculated_mol_wt=100672
     Region          66..90
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          91..118
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          <114..>323
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          154..179
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          180..199
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          200..222
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          223..245
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          246..268
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          269..291
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          292..313
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          352..443
                     /region_name="ZU5"
                     /note="ZU5 domain; cl02517"
                     /db_xref="CDD:470600"
     Region          448..480
                     /region_name="Peptidase_S68"
                     /note="Peptidase S68; pfam10461"
                     /db_xref="CDD:463098"
     Region          492..564
                     /region_name="ZU5"
                     /note="ZU5 domain; cl02517"
                     /db_xref="CDD:470600"
     Region          798..883
                     /region_name="Death_PIDD"
                     /note="Death Domain of p53-induced protein with a death
                     domain; cd08779"
                     /db_xref="CDD:260049"
     Site            order(806..807,809,811,836..839,842)
                     /site_type="other"
                     /note="Type III interaction site [polypeptide binding]"
                     /db_xref="CDD:260049"
     Site            order(811,815,818..820,823..824,831,869,871..874,877)
                     /site_type="other"
                     /note="PIDD-RAIDD interaction site [polypeptide binding]"
                     /db_xref="CDD:260049"
     Site            order(811,815,818..819,823..824,831,869..870)
                     /site_type="other"
                     /note="Type I interaction site [polypeptide binding]"
                     /db_xref="CDD:260049"
     Site            order(871..874,877)
                     /site_type="other"
                     /note="Type II interaction site [polypeptide binding]"
                     /db_xref="CDD:260049"
     CDS             1..920
                     /gene="PIDD1"
                     /gene_synonym="LRDD; MRT75; PIDD"
                     /coded_by="XM_054369311.1:440..3202"
                     /db_xref="GeneID:55367"
                     /db_xref="HGNC:HGNC:16491"
                     /db_xref="MIM:605247"
ORIGIN      
        1 mqlpralpgq aclragtcla skdrrwamaa tvegpeleaa aaagdaseds dagsralpfl
       61 ggnrlsldly pggcqqllhl cvqqplqllq veflrlsthe dpqlleatla qlpqslsclr
      121 slvlkggqrr dtlgaclrga ltnlpaglsg lahlahldls fnsletlpac vlqmrglgal
      181 llshnclsel pealgalpal tfltvthnrl qtlppalgal stlqrldlsq nlldtlppei
      241 gglgslleln lasnrlqslp aslaglrslr llvlhsnlla svpadlarlp lltrldlrdn
      301 qlrdlppell dapfvrlqgn plgeaspdap sspvaalipe mprlfltsdl dsfpvtprgc
      361 svtlacgvrl qfpagatatp itiryrlllp epglvplgph dallshvlel qphgvafqqd
      421 vglwllftpp qarrcrevvv rtrndnswgd letyleeeap qrlwahcqvp hfswflvvsr
      481 pvsnaclvpp egtllcssgh pgvkvifppg ateeprrvsm qvvrmagrel qallgepeaa
      541 vspllclsqs gppsflqpvt vqlplpsgit glsldrsrlh llywappaat wdditaqvvl
      601 elthlyarfq vthfswywlw yttkncvggl arkawerlrl hrvnlialqr rrdpeqvllq
      661 clprnkvdat lrrlleryrg pepsdtvemf egeeffaafe rgidvdadrp dcvegricfv
      721 fyshlknvke vsfyrgavpv rvpeeaeaar qrkgadalwm atlpiklprl rgsegprrga
      781 glslaplnlg daetgfltqs nllsvagrlg ldwpavalhl gvsyrevqri rhefrddlde
      841 qirhmlfswa erqagqpgav gllvqaleqs drqdvaeevr avlelgrrky qdsirrmgla
      901 pkdpalpgss apqppepaqa
//
LOCUS       XP_054225287             910 aa            linear   PRI 05-AUG-2025
DEFINITION  p53-induced death domain-containing protein 1 isoform X4 [Homo
            sapiens].
ACCESSION   XP_054225287
VERSION     XP_054225287.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369312.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..910
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..910
                     /product="p53-induced death domain-containing protein 1
                     isoform X4"
                     /calculated_mol_wt=99609
     Region          39..63
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          64..91
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          <87..>296
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          127..152
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          153..172
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          173..195
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          196..218
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          219..241
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          242..264
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          265..286
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          325..416
                     /region_name="ZU5"
                     /note="ZU5 domain; cl02517"
                     /db_xref="CDD:470600"
     Region          421..453
                     /region_name="Peptidase_S68"
                     /note="Peptidase S68; pfam10461"
                     /db_xref="CDD:463098"
     Region          465..537
                     /region_name="ZU5"
                     /note="ZU5 domain; cl02517"
                     /db_xref="CDD:470600"
     Region          788..873
                     /region_name="Death_PIDD"
                     /note="Death Domain of p53-induced protein with a death
                     domain; cd08779"
                     /db_xref="CDD:260049"
     Site            order(796..797,799,801,826..829,832)
                     /site_type="other"
                     /note="Type III interaction site [polypeptide binding]"
                     /db_xref="CDD:260049"
     Site            order(801,805,808..810,813..814,821,859,861..864,867)
                     /site_type="other"
                     /note="PIDD-RAIDD interaction site [polypeptide binding]"
                     /db_xref="CDD:260049"
     Site            order(801,805,808..809,813..814,821,859..860)
                     /site_type="other"
                     /note="Type I interaction site [polypeptide binding]"
                     /db_xref="CDD:260049"
     Site            order(861..864,867)
                     /site_type="other"
                     /note="Type II interaction site [polypeptide binding]"
                     /db_xref="CDD:260049"
     CDS             1..910
                     /gene="PIDD1"
                     /gene_synonym="LRDD; MRT75; PIDD"
                     /coded_by="XM_054369312.1:1369..4101"
                     /db_xref="GeneID:55367"
                     /db_xref="HGNC:HGNC:16491"
                     /db_xref="MIM:605247"
ORIGIN      
        1 maatvegpel eaaaaagdas edsdagsral pflggnrlsl dlypggcqql lhlcvqqplq
       61 llqveflrls thedpqllea tlaqlpqsls clrslvlkgg qrrdtlgacl rgaltnlpag
      121 lsglahlahl dlsfnsletl pacvlqmrgl galllshncl selpealgal paltfltvth
      181 nrlqtlppal galstlqrld lsqnlldtlp peigglgsll elnlasnrlq slpaslaglr
      241 slrllvlhsn llasvpadla rlplltrldl rdnqlrdlpp elldapfvrl qgnplgeasp
      301 dapsspvaal ipemprlflt sdldsfpvtp rgcsvtlacg vrlqfpagat atpitiryrl
      361 llpepglvpl gphdallshv lelqphgvaf qqdvglwllf tppqarrcre vvvrtrndns
      421 wgdletylee eapqrlwahc qvphfswflv vsrpvsnacl vppegtllcs sghpgvkvif
      481 ppgateeprr vsmqvvrmag relqallgep eaavspllcl sqsgppsflq pvtvqlplps
      541 gitglsldrs rlhllywapp aatwdditaq vvlelthlya rfqvthfswy wlwyttkncv
      601 gglarkawer lrlhrvnlia lqrrrdpeqv llqclprnkv datlrrller yrgpepsdtv
      661 emfegeeffa afergidvda drpdcvegri cfvfyshlkn vkevyvtttl dreaqavrgq
      721 vsfyrgavpv rvpeeaeaar qrkgadalwm atlpiklprl rgsegprrga glslaplnlg
      781 daetgfltqs nllsvagrlg ldwpavalhl gvsyrevqri rhefrddlde qirhmlfswa
      841 erqagqpgav gllvqaleqs drqdvaeevr avlelgrrky qdsirrmgla pkdpalpgss
      901 apqppepaqa
//
LOCUS       XP_054225288             822 aa            linear   PRI 05-AUG-2025
DEFINITION  p53-induced death domain-containing protein 1 isoform X15 [Homo
            sapiens].
ACCESSION   XP_054225288
VERSION     XP_054225288.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369313.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..822
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..822
                     /product="p53-induced death domain-containing protein 1
                     isoform X15"
                     /calculated_mol_wt=89653
     Region          39..63
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          64..91
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          <87..>296
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          127..152
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          153..172
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          173..195
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          196..218
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          219..241
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          242..264
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          265..286
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          325..416
                     /region_name="ZU5"
                     /note="ZU5 domain; cl02517"
                     /db_xref="CDD:470600"
     Region          421..453
                     /region_name="Peptidase_S68"
                     /note="Peptidase S68; pfam10461"
                     /db_xref="CDD:463098"
     Region          465..537
                     /region_name="ZU5"
                     /note="ZU5 domain; cl02517"
                     /db_xref="CDD:470600"
     CDS             1..822
                     /gene="PIDD1"
                     /gene_synonym="LRDD; MRT75; PIDD"
                     /coded_by="XM_054369313.1:76..2544"
                     /db_xref="GeneID:55367"
                     /db_xref="HGNC:HGNC:16491"
                     /db_xref="MIM:605247"
ORIGIN      
        1 maatvegpel eaaaaagdas edsdagsral pflggnrlsl dlypggcqql lhlcvqqplq
       61 llqveflrls thedpqllea tlaqlpqsls clrslvlkgg qrrdtlgacl rgaltnlpag
      121 lsglahlahl dlsfnsletl pacvlqmrgl galllshncl selpealgal paltfltvth
      181 nrlqtlppal galstlqrld lsqnlldtlp peigglgsll elnlasnrlq slpaslaglr
      241 slrllvlhsn llasvpadla rlplltrldl rdnqlrdlpp elldapfvrl qgnplgeasp
      301 dapsspvaal ipemprlflt sdldsfpvtp rgcsvtlacg vrlqfpagat atpitiryrl
      361 llpepglvpl gphdallshv lelqphgvaf qqdvglwllf tppqarrcre vvvrtrndns
      421 wgdletylee eapqrlwahc qvphfswflv vsrpvsnacl vppegtllcs sghpgvkvif
      481 ppgateeprr vsmqvvrmag relqallgep eaavspllcl sqsgppsflq pvtvqlplps
      541 gitglsldrs rlhllywapp aatwdditaq vvlelthlya rfqvthfsws vppsflsppp
      601 pvctalltps sprywlwytt kncvgglark awerlrlhrv nlialqrrrd peqvllqclp
      661 rnkvdatlrr lleryrgpep sdtvemfege effaafergi dvdadrpdcv egricfvfys
      721 hlknvkevsf yrgavpvrvp eeaeaarqrk gadalwmatl piklpvglrd srgagqdrgp
      781 gvtrvtwwsw gwspglnalf psnrdfegpr ghggglaspw hp
//
LOCUS       XP_054225289             934 aa            linear   PRI 05-AUG-2025
DEFINITION  p53-induced death domain-containing protein 1 isoform X2 [Homo
            sapiens].
ACCESSION   XP_054225289
VERSION     XP_054225289.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369314.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..934
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..934
                     /product="p53-induced death domain-containing protein 1
                     isoform X2"
                     /calculated_mol_wt=102039
     Region          39..63
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          64..91
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          <87..>296
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          127..152
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          153..172
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          173..195
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          196..218
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          219..241
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          242..264
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          265..286
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          325..416
                     /region_name="ZU5"
                     /note="ZU5 domain; cl02517"
                     /db_xref="CDD:470600"
     Region          421..453
                     /region_name="Peptidase_S68"
                     /note="Peptidase S68; pfam10461"
                     /db_xref="CDD:463098"
     Region          465..537
                     /region_name="ZU5"
                     /note="ZU5 domain; cl02517"
                     /db_xref="CDD:470600"
     Region          812..897
                     /region_name="Death_PIDD"
                     /note="Death Domain of p53-induced protein with a death
                     domain; cd08779"
                     /db_xref="CDD:260049"
     Site            order(820..821,823,825,850..853,856)
                     /site_type="other"
                     /note="Type III interaction site [polypeptide binding]"
                     /db_xref="CDD:260049"
     Site            order(825,829,832..834,837..838,845,883,885..888,891)
                     /site_type="other"
                     /note="PIDD-RAIDD interaction site [polypeptide binding]"
                     /db_xref="CDD:260049"
     Site            order(825,829,832..833,837..838,845,883..884)
                     /site_type="other"
                     /note="Type I interaction site [polypeptide binding]"
                     /db_xref="CDD:260049"
     Site            order(885..888,891)
                     /site_type="other"
                     /note="Type II interaction site [polypeptide binding]"
                     /db_xref="CDD:260049"
     CDS             1..934
                     /gene="PIDD1"
                     /gene_synonym="LRDD; MRT75; PIDD"
                     /coded_by="XM_054369314.1:192..2996"
                     /db_xref="GeneID:55367"
                     /db_xref="HGNC:HGNC:16491"
                     /db_xref="MIM:605247"
ORIGIN      
        1 maatvegpel eaaaaagdas edsdagsral pflggnrlsl dlypggcqql lhlcvqqplq
       61 llqveflrls thedpqllea tlaqlpqsls clrslvlkgg qrrdtlgacl rgaltnlpag
      121 lsglahlahl dlsfnsletl pacvlqmrgl galllshncl selpealgal paltfltvth
      181 nrlqtlppal galstlqrld lsqnlldtlp peigglgsll elnlasnrlq slpaslaglr
      241 slrllvlhsn llasvpadla rlplltrldl rdnqlrdlpp elldapfvrl qgnplgeasp
      301 dapsspvaal ipemprlflt sdldsfpvtp rgcsvtlacg vrlqfpagat atpitiryrl
      361 llpepglvpl gphdallshv lelqphgvaf qqdvglwllf tppqarrcre vvvrtrndns
      421 wgdletylee eapqrlwahc qvphfswflv vsrpvsnacl vppegtllcs sghpgvkvif
      481 ppgateeprr vsmqvvrmag relqallgep eaavspllcl sqsgppsflq pvtvqlplps
      541 gitglsldrs rlhllywapp aatwdditaq vvlelthlya rfqvthfsws vppsflsppp
      601 pvctalltps sprywlwytt kncvgglark awerlrlhrv nlialqrrrd peqvllqclp
      661 rnkvdatlrr lleryrgpep sdtvemfege effaafergi dvdadrpdcv egricfvfys
      721 hlknvkevyv tttldreaqa vrgqvsfyrg avpvrvpeea eaarqrkgad alwmatlpik
      781 lprlrgsegp rrgaglslap lnlgdaetgf ltqsnllsva grlgldwpav alhlgvsyre
      841 vqrirhefrd dldeqirhml fswaerqagq pgavgllvqa leqsdrqdva eevravlelg
      901 rrkyqdsirr mglapkdpal pgssapqppe paqa
//
LOCUS       XP_054225290             788 aa            linear   PRI 05-AUG-2025
DEFINITION  p53-induced death domain-containing protein 1 isoform X5 [Homo
            sapiens].
ACCESSION   XP_054225290
VERSION     XP_054225290.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369315.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..788
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..788
                     /product="p53-induced death domain-containing protein 1
                     isoform X5"
                     /calculated_mol_wt=86721
     Region          <1..>149
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          7..26
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          27..49
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          50..72
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          73..95
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          96..118
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          119..140
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          179..270
                     /region_name="ZU5"
                     /note="ZU5 domain; cl02517"
                     /db_xref="CDD:470600"
     Region          275..307
                     /region_name="Peptidase_S68"
                     /note="Peptidase S68; pfam10461"
                     /db_xref="CDD:463098"
     Region          319..391
                     /region_name="ZU5"
                     /note="ZU5 domain; cl02517"
                     /db_xref="CDD:470600"
     Region          666..751
                     /region_name="Death_PIDD"
                     /note="Death Domain of p53-induced protein with a death
                     domain; cd08779"
                     /db_xref="CDD:260049"
     Site            order(674..675,677,679,704..707,710)
                     /site_type="other"
                     /note="Type III interaction site [polypeptide binding]"
                     /db_xref="CDD:260049"
     Site            order(679,683,686..688,691..692,699,737,739..742,745)
                     /site_type="other"
                     /note="PIDD-RAIDD interaction site [polypeptide binding]"
                     /db_xref="CDD:260049"
     Site            order(679,683,686..687,691..692,699,737..738)
                     /site_type="other"
                     /note="Type I interaction site [polypeptide binding]"
                     /db_xref="CDD:260049"
     Site            order(739..742,745)
                     /site_type="other"
                     /note="Type II interaction site [polypeptide binding]"
                     /db_xref="CDD:260049"
     CDS             1..788
                     /gene="PIDD1"
                     /gene_synonym="LRDD; MRT75; PIDD"
                     /coded_by="XM_054369315.1:293..2659"
                     /db_xref="GeneID:55367"
                     /db_xref="HGNC:HGNC:16491"
                     /db_xref="MIM:605247"
ORIGIN      
        1 mrglgallls hnclselpea lgalpaltfl tvthnrlqtl ppalgalstl qrldlsqnll
       61 dtlppeiggl gsllelnlas nrlqslpasl aglrslrllv lhsnllasvp adlarlpllt
      121 rldlrdnqlr dlppelldap fvrlqgnplg easpdapssp vaalipempr lfltsdldsf
      181 pvtprgcsvt lacgvrlqfp agatatpiti ryrlllpepg lvplgphdal lshvlelqph
      241 gvafqqdvgl wllftppqar rcrevvvrtr ndnswgdlet yleeeapqrl wahcqvphfs
      301 wflvvsrpvs naclvppegt llcssghpgv kvifppgate eprrvsmqvv rmagrelqal
      361 lgepeaavsp llclsqsgpp sflqpvtvql plpsgitgls ldrsrlhlly wappaatwdd
      421 itaqvvlelt hlyarfqvth fswsvppsfl sppppvctal ltpssprywl wyttkncvgg
      481 larkawerlr lhrvnlialq rrrdpeqvll qclprnkvda tlrrlleryr gpepsdtvem
      541 fegeeffaaf ergidvdadr pdcvegricf vfyshlknvk evyvtttldr eaqavrgqvs
      601 fyrgavpvrv peeaeaarqr kgadalwmat lpiklprlrg segprrgagl slaplnlgda
      661 etgfltqsnl lsvagrlgld wpavalhlgv syrevqrirh efrddldeqi rhmlfswaer
      721 qagqpgavgl lvqaleqsdr qdvaeevrav lelgrrkyqd sirrmglapk dpalpgssap
      781 qppepaqa
//
LOCUS       XP_054225291             771 aa            linear   PRI 05-AUG-2025
DEFINITION  p53-induced death domain-containing protein 1 isoform X6 [Homo
            sapiens].
ACCESSION   XP_054225291
VERSION     XP_054225291.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369316.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..771
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..771
                     /product="p53-induced death domain-containing protein 1
                     isoform X6"
                     /calculated_mol_wt=84832
     Region          <1..>149
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          7..26
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          27..49
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          50..72
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          73..95
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          96..118
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          119..140
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          179..270
                     /region_name="ZU5"
                     /note="ZU5 domain; cl02517"
                     /db_xref="CDD:470600"
     Region          275..307
                     /region_name="Peptidase_S68"
                     /note="Peptidase S68; pfam10461"
                     /db_xref="CDD:463098"
     Region          319..391
                     /region_name="ZU5"
                     /note="ZU5 domain; cl02517"
                     /db_xref="CDD:470600"
     Region          649..734
                     /region_name="Death_PIDD"
                     /note="Death Domain of p53-induced protein with a death
                     domain; cd08779"
                     /db_xref="CDD:260049"
     Site            order(657..658,660,662,687..690,693)
                     /site_type="other"
                     /note="Type III interaction site [polypeptide binding]"
                     /db_xref="CDD:260049"
     Site            order(662,666,669..671,674..675,682,720,722..725,728)
                     /site_type="other"
                     /note="PIDD-RAIDD interaction site [polypeptide binding]"
                     /db_xref="CDD:260049"
     Site            order(662,666,669..670,674..675,682,720..721)
                     /site_type="other"
                     /note="Type I interaction site [polypeptide binding]"
                     /db_xref="CDD:260049"
     Site            order(722..725,728)
                     /site_type="other"
                     /note="Type II interaction site [polypeptide binding]"
                     /db_xref="CDD:260049"
     CDS             1..771
                     /gene="PIDD1"
                     /gene_synonym="LRDD; MRT75; PIDD"
                     /coded_by="XM_054369316.1:293..2608"
                     /db_xref="GeneID:55367"
                     /db_xref="HGNC:HGNC:16491"
                     /db_xref="MIM:605247"
ORIGIN      
        1 mrglgallls hnclselpea lgalpaltfl tvthnrlqtl ppalgalstl qrldlsqnll
       61 dtlppeiggl gsllelnlas nrlqslpasl aglrslrllv lhsnllasvp adlarlpllt
      121 rldlrdnqlr dlppelldap fvrlqgnplg easpdapssp vaalipempr lfltsdldsf
      181 pvtprgcsvt lacgvrlqfp agatatpiti ryrlllpepg lvplgphdal lshvlelqph
      241 gvafqqdvgl wllftppqar rcrevvvrtr ndnswgdlet yleeeapqrl wahcqvphfs
      301 wflvvsrpvs naclvppegt llcssghpgv kvifppgate eprrvsmqvv rmagrelqal
      361 lgepeaavsp llclsqsgpp sflqpvtvql plpsgitgls ldrsrlhlly wappaatwdd
      421 itaqvvlelt hlyarfqvth fswsvppsfl sppppvctal ltpssprywl wyttkncvgg
      481 larkawerlr lhrvnlialq rrrdpeqvll qclprnkvda tlrrlleryr gpepsdtvem
      541 fegeeffaaf ergidvdadr pdcvegricf vfyshlknvk evsfyrgavp vrvpeeaeaa
      601 rqrkgadalw matlpiklpr lrgsegprrg aglslaplnl gdaetgfltq snllsvagrl
      661 gldwpavalh lgvsyrevqr irhefrddld eqirhmlfsw aerqagqpga vgllvqaleq
      721 sdrqdvaeev ravlelgrrk yqdsirrmgl apkdpalpgs sapqppepaq a
//
LOCUS       XP_054225292             764 aa            linear   PRI 05-AUG-2025
DEFINITION  p53-induced death domain-containing protein 1 isoform X7 [Homo
            sapiens].
ACCESSION   XP_054225292
VERSION     XP_054225292.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369317.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..764
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..764
                     /product="p53-induced death domain-containing protein 1
                     isoform X7"
                     /calculated_mol_wt=84291
     Region          <1..>149
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          7..26
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          27..49
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          50..72
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          73..95
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          96..118
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          119..140
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          179..270
                     /region_name="ZU5"
                     /note="ZU5 domain; cl02517"
                     /db_xref="CDD:470600"
     Region          275..307
                     /region_name="Peptidase_S68"
                     /note="Peptidase S68; pfam10461"
                     /db_xref="CDD:463098"
     Region          319..391
                     /region_name="ZU5"
                     /note="ZU5 domain; cl02517"
                     /db_xref="CDD:470600"
     Region          642..727
                     /region_name="Death_PIDD"
                     /note="Death Domain of p53-induced protein with a death
                     domain; cd08779"
                     /db_xref="CDD:260049"
     Site            order(650..651,653,655,680..683,686)
                     /site_type="other"
                     /note="Type III interaction site [polypeptide binding]"
                     /db_xref="CDD:260049"
     Site            order(655,659,662..664,667..668,675,713,715..718,721)
                     /site_type="other"
                     /note="PIDD-RAIDD interaction site [polypeptide binding]"
                     /db_xref="CDD:260049"
     Site            order(655,659,662..663,667..668,675,713..714)
                     /site_type="other"
                     /note="Type I interaction site [polypeptide binding]"
                     /db_xref="CDD:260049"
     Site            order(715..718,721)
                     /site_type="other"
                     /note="Type II interaction site [polypeptide binding]"
                     /db_xref="CDD:260049"
     CDS             1..764
                     /gene="PIDD1"
                     /gene_synonym="LRDD; MRT75; PIDD"
                     /coded_by="XM_054369317.1:293..2587"
                     /db_xref="GeneID:55367"
                     /db_xref="HGNC:HGNC:16491"
                     /db_xref="MIM:605247"
ORIGIN      
        1 mrglgallls hnclselpea lgalpaltfl tvthnrlqtl ppalgalstl qrldlsqnll
       61 dtlppeiggl gsllelnlas nrlqslpasl aglrslrllv lhsnllasvp adlarlpllt
      121 rldlrdnqlr dlppelldap fvrlqgnplg easpdapssp vaalipempr lfltsdldsf
      181 pvtprgcsvt lacgvrlqfp agatatpiti ryrlllpepg lvplgphdal lshvlelqph
      241 gvafqqdvgl wllftppqar rcrevvvrtr ndnswgdlet yleeeapqrl wahcqvphfs
      301 wflvvsrpvs naclvppegt llcssghpgv kvifppgate eprrvsmqvv rmagrelqal
      361 lgepeaavsp llclsqsgpp sflqpvtvql plpsgitgls ldrsrlhlly wappaatwdd
      421 itaqvvlelt hlyarfqvth fswywlwytt kncvgglark awerlrlhrv nlialqrrrd
      481 peqvllqclp rnkvdatlrr lleryrgpep sdtvemfege effaafergi dvdadrpdcv
      541 egricfvfys hlknvkevyv tttldreaqa vrgqvsfyrg avpvrvpeea eaarqrkgad
      601 alwmatlpik lprlrgsegp rrgaglslap lnlgdaetgf ltqsnllsva grlgldwpav
      661 alhlgvsyre vqrirhefrd dldeqirhml fswaerqagq pgavgllvqa leqsdrqdva
      721 eevravlelg rrkyqdsirr mglapkdpal pgssapqppe paqa
//
LOCUS       XP_054225293             747 aa            linear   PRI 05-AUG-2025
DEFINITION  p53-induced death domain-containing protein 1 isoform X8 [Homo
            sapiens].
ACCESSION   XP_054225293
VERSION     XP_054225293.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369318.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..747
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..747
                     /product="p53-induced death domain-containing protein 1
                     isoform X8"
                     /calculated_mol_wt=82402
     Region          <1..>149
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          7..26
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          27..49
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          50..72
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          73..95
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          96..118
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          119..140
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          179..270
                     /region_name="ZU5"
                     /note="ZU5 domain; cl02517"
                     /db_xref="CDD:470600"
     Region          275..307
                     /region_name="Peptidase_S68"
                     /note="Peptidase S68; pfam10461"
                     /db_xref="CDD:463098"
     Region          319..391
                     /region_name="ZU5"
                     /note="ZU5 domain; cl02517"
                     /db_xref="CDD:470600"
     Region          625..710
                     /region_name="Death_PIDD"
                     /note="Death Domain of p53-induced protein with a death
                     domain; cd08779"
                     /db_xref="CDD:260049"
     Site            order(633..634,636,638,663..666,669)
                     /site_type="other"
                     /note="Type III interaction site [polypeptide binding]"
                     /db_xref="CDD:260049"
     Site            order(638,642,645..647,650..651,658,696,698..701,704)
                     /site_type="other"
                     /note="PIDD-RAIDD interaction site [polypeptide binding]"
                     /db_xref="CDD:260049"
     Site            order(638,642,645..646,650..651,658,696..697)
                     /site_type="other"
                     /note="Type I interaction site [polypeptide binding]"
                     /db_xref="CDD:260049"
     Site            order(698..701,704)
                     /site_type="other"
                     /note="Type II interaction site [polypeptide binding]"
                     /db_xref="CDD:260049"
     CDS             1..747
                     /gene="PIDD1"
                     /gene_synonym="LRDD; MRT75; PIDD"
                     /coded_by="XM_054369318.1:293..2536"
                     /db_xref="GeneID:55367"
                     /db_xref="HGNC:HGNC:16491"
                     /db_xref="MIM:605247"
ORIGIN      
        1 mrglgallls hnclselpea lgalpaltfl tvthnrlqtl ppalgalstl qrldlsqnll
       61 dtlppeiggl gsllelnlas nrlqslpasl aglrslrllv lhsnllasvp adlarlpllt
      121 rldlrdnqlr dlppelldap fvrlqgnplg easpdapssp vaalipempr lfltsdldsf
      181 pvtprgcsvt lacgvrlqfp agatatpiti ryrlllpepg lvplgphdal lshvlelqph
      241 gvafqqdvgl wllftppqar rcrevvvrtr ndnswgdlet yleeeapqrl wahcqvphfs
      301 wflvvsrpvs naclvppegt llcssghpgv kvifppgate eprrvsmqvv rmagrelqal
      361 lgepeaavsp llclsqsgpp sflqpvtvql plpsgitgls ldrsrlhlly wappaatwdd
      421 itaqvvlelt hlyarfqvth fswywlwytt kncvgglark awerlrlhrv nlialqrrrd
      481 peqvllqclp rnkvdatlrr lleryrgpep sdtvemfege effaafergi dvdadrpdcv
      541 egricfvfys hlknvkevsf yrgavpvrvp eeaeaarqrk gadalwmatl piklprlrgs
      601 egprrgagls laplnlgdae tgfltqsnll svagrlgldw pavalhlgvs yrevqrirhe
      661 frddldeqir hmlfswaerq agqpgavgll vqaleqsdrq dvaeevravl elgrrkyqds
      721 irrmglapkd palpgssapq ppepaqa
//
LOCUS       XP_054225294             621 aa            linear   PRI 05-AUG-2025
DEFINITION  p53-induced death domain-containing protein 1 isoform X16 [Homo
            sapiens].
ACCESSION   XP_054225294
VERSION     XP_054225294.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369319.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..621
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..621
                     /product="p53-induced death domain-containing protein 1
                     isoform X16"
                     /calculated_mol_wt=66264
     Region          39..63
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          64..91
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          <114..>299
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          127..152
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          153..172
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          173..195
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          196..218
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          219..241
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          242..264
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          265..286
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          325..416
                     /region_name="ZU5"
                     /note="ZU5 domain; cl02517"
                     /db_xref="CDD:470600"
     Region          421..453
                     /region_name="Peptidase_S68"
                     /note="Peptidase S68; pfam10461"
                     /db_xref="CDD:463098"
     Region          465..537
                     /region_name="ZU5"
                     /note="ZU5 domain; cl02517"
                     /db_xref="CDD:470600"
     CDS             1..621
                     /gene="PIDD1"
                     /gene_synonym="LRDD; MRT75; PIDD"
                     /coded_by="XM_054369319.1:76..1941"
                     /db_xref="GeneID:55367"
                     /db_xref="HGNC:HGNC:16491"
                     /db_xref="MIM:605247"
ORIGIN      
        1 maatvegpel eaaaaagdas edsdagsral pflggnrlsl dlypggcqql lhlcvqqplq
       61 llqveflrls thedpqllea tlaqlpqsls clrslvlkgg qrrdtlgacl rgaltnlpag
      121 lsglahlahl dlsfnsletl pacvlqmrgl galllshncl selpealgal paltfltvth
      181 nrlqtlppal galstlqrld lsqnlldtlp peigglgsll elnlasnrlq slpaslaglr
      241 slrllvlhsn llasvpadla rlplltrldl rdnqlrdlpp elldapfvrl qgnplgeasp
      301 dapsspvaal ipemprlflt sdldsfpvtp rgcsvtlacg vrlqfpagat atpitiryrl
      361 llpepglvpl gphdallshv lelqphgvaf qqdvglwllf tppqarrcre vvvrtrndns
      421 wgdletylee eapqrlwahc qvphfswflv vsrpvsnacl vppegtllcs sghpgvkvif
      481 ppgateeprr vsmqvvrmag relqallgep eaavspllcl sqsgppsflq pvtvqlplps
      541 gitglsldrs rlhllywapp aatwdditaq vvlelthlya rfqvlalvhh qelcgrpgse
      601 glgaaaaapc ephrsaaapg p
//
LOCUS       XP_054225295             621 aa            linear   PRI 05-AUG-2025
DEFINITION  p53-induced death domain-containing protein 1 isoform X9 [Homo
            sapiens].
ACCESSION   XP_054225295
VERSION     XP_054225295.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369320.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..621
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..621
                     /product="p53-induced death domain-containing protein 1
                     isoform X9"
                     /calculated_mol_wt=69047
     Region          12..103
                     /region_name="ZU5"
                     /note="ZU5 domain; cl02517"
                     /db_xref="CDD:470600"
     Region          108..140
                     /region_name="Peptidase_S68"
                     /note="Peptidase S68; pfam10461"
                     /db_xref="CDD:463098"
     Region          152..224
                     /region_name="ZU5"
                     /note="ZU5 domain; cl02517"
                     /db_xref="CDD:470600"
     Region          499..584
                     /region_name="Death_PIDD"
                     /note="Death Domain of p53-induced protein with a death
                     domain; cd08779"
                     /db_xref="CDD:260049"
     Site            order(507..508,510,512,537..540,543)
                     /site_type="other"
                     /note="Type III interaction site [polypeptide binding]"
                     /db_xref="CDD:260049"
     Site            order(512,516,519..521,524..525,532,570,572..575,578)
                     /site_type="other"
                     /note="PIDD-RAIDD interaction site [polypeptide binding]"
                     /db_xref="CDD:260049"
     Site            order(512,516,519..520,524..525,532,570..571)
                     /site_type="other"
                     /note="Type I interaction site [polypeptide binding]"
                     /db_xref="CDD:260049"
     Site            order(572..575,578)
                     /site_type="other"
                     /note="Type II interaction site [polypeptide binding]"
                     /db_xref="CDD:260049"
     CDS             1..621
                     /gene="PIDD1"
                     /gene_synonym="LRDD; MRT75; PIDD"
                     /coded_by="XM_054369320.1:518..2383"
                     /db_xref="GeneID:55367"
                     /db_xref="HGNC:HGNC:16491"
                     /db_xref="MIM:605247"
ORIGIN      
        1 mprlfltsdl dsfpvtprgc svtlacgvrl qfpagatatp itiryrlllp epglvplgph
       61 dallshvlel qphgvafqqd vglwllftpp qarrcrevvv rtrndnswgd letyleeeap
      121 qrlwahcqvp hfswflvvsr pvsnaclvpp egtllcssgh pgvkvifppg ateeprrvsm
      181 qvvrmagrel qallgepeaa vspllclsqs gppsflqpvt vqlplpsgit glsldrsrlh
      241 llywappaat wdditaqvvl elthlyarfq vthfswsvpp sflsppppvc talltpsspr
      301 ywlwyttknc vgglarkawe rlrlhrvnli alqrrrdpeq vllqclprnk vdatlrrlle
      361 ryrgpepsdt vemfegeeff aafergidvd adrpdcvegr icfvfyshlk nvkevyvttt
      421 ldreaqavrg qvsfyrgavp vrvpeeaeaa rqrkgadalw matlpiklpr lrgsegprrg
      481 aglslaplnl gdaetgfltq snllsvagrl gldwpavalh lgvsyrevqr irhefrddld
      541 eqirhmlfsw aerqagqpga vgllvqaleq sdrqdvaeev ravlelgrrk yqdsirrmgl
      601 apkdpalpgs sapqppepaq a
//
LOCUS       XP_054225296             621 aa            linear   PRI 05-AUG-2025
DEFINITION  p53-induced death domain-containing protein 1 isoform X9 [Homo
            sapiens].
ACCESSION   XP_054225296
VERSION     XP_054225296.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369321.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..621
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..621
                     /product="p53-induced death domain-containing protein 1
                     isoform X9"
                     /calculated_mol_wt=69047
     Region          12..103
                     /region_name="ZU5"
                     /note="ZU5 domain; cl02517"
                     /db_xref="CDD:470600"
     Region          108..140
                     /region_name="Peptidase_S68"
                     /note="Peptidase S68; pfam10461"
                     /db_xref="CDD:463098"
     Region          152..224
                     /region_name="ZU5"
                     /note="ZU5 domain; cl02517"
                     /db_xref="CDD:470600"
     Region          499..584
                     /region_name="Death_PIDD"
                     /note="Death Domain of p53-induced protein with a death
                     domain; cd08779"
                     /db_xref="CDD:260049"
     Site            order(507..508,510,512,537..540,543)
                     /site_type="other"
                     /note="Type III interaction site [polypeptide binding]"
                     /db_xref="CDD:260049"
     Site            order(512,516,519..521,524..525,532,570,572..575,578)
                     /site_type="other"
                     /note="PIDD-RAIDD interaction site [polypeptide binding]"
                     /db_xref="CDD:260049"
     Site            order(512,516,519..520,524..525,532,570..571)
                     /site_type="other"
                     /note="Type I interaction site [polypeptide binding]"
                     /db_xref="CDD:260049"
     Site            order(572..575,578)
                     /site_type="other"
                     /note="Type II interaction site [polypeptide binding]"
                     /db_xref="CDD:260049"
     CDS             1..621
                     /gene="PIDD1"
                     /gene_synonym="LRDD; MRT75; PIDD"
                     /coded_by="XM_054369321.1:307..2172"
                     /db_xref="GeneID:55367"
                     /db_xref="HGNC:HGNC:16491"
                     /db_xref="MIM:605247"
ORIGIN      
        1 mprlfltsdl dsfpvtprgc svtlacgvrl qfpagatatp itiryrlllp epglvplgph
       61 dallshvlel qphgvafqqd vglwllftpp qarrcrevvv rtrndnswgd letyleeeap
      121 qrlwahcqvp hfswflvvsr pvsnaclvpp egtllcssgh pgvkvifppg ateeprrvsm
      181 qvvrmagrel qallgepeaa vspllclsqs gppsflqpvt vqlplpsgit glsldrsrlh
      241 llywappaat wdditaqvvl elthlyarfq vthfswsvpp sflsppppvc talltpsspr
      301 ywlwyttknc vgglarkawe rlrlhrvnli alqrrrdpeq vllqclprnk vdatlrrlle
      361 ryrgpepsdt vemfegeeff aafergidvd adrpdcvegr icfvfyshlk nvkevyvttt
      421 ldreaqavrg qvsfyrgavp vrvpeeaeaa rqrkgadalw matlpiklpr lrgsegprrg
      481 aglslaplnl gdaetgfltq snllsvagrl gldwpavalh lgvsyrevqr irhefrddld
      541 eqirhmlfsw aerqagqpga vgllvqaleq sdrqdvaeev ravlelgrrk yqdsirrmgl
      601 apkdpalpgs sapqppepaq a
//
LOCUS       XP_054225297             597 aa            linear   PRI 05-AUG-2025
DEFINITION  p53-induced death domain-containing protein 1 isoform X10 [Homo
            sapiens].
ACCESSION   XP_054225297
VERSION     XP_054225297.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369322.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..597
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..597
                     /product="p53-induced death domain-containing protein 1
                     isoform X10"
                     /calculated_mol_wt=66617
     Region          12..103
                     /region_name="ZU5"
                     /note="ZU5 domain; cl02517"
                     /db_xref="CDD:470600"
     Region          108..140
                     /region_name="Peptidase_S68"
                     /note="Peptidase S68; pfam10461"
                     /db_xref="CDD:463098"
     Region          152..224
                     /region_name="ZU5"
                     /note="ZU5 domain; cl02517"
                     /db_xref="CDD:470600"
     Region          475..560
                     /region_name="Death_PIDD"
                     /note="Death Domain of p53-induced protein with a death
                     domain; cd08779"
                     /db_xref="CDD:260049"
     Site            order(483..484,486,488,513..516,519)
                     /site_type="other"
                     /note="Type III interaction site [polypeptide binding]"
                     /db_xref="CDD:260049"
     Site            order(488,492,495..497,500..501,508,546,548..551,554)
                     /site_type="other"
                     /note="PIDD-RAIDD interaction site [polypeptide binding]"
                     /db_xref="CDD:260049"
     Site            order(488,492,495..496,500..501,508,546..547)
                     /site_type="other"
                     /note="Type I interaction site [polypeptide binding]"
                     /db_xref="CDD:260049"
     Site            order(548..551,554)
                     /site_type="other"
                     /note="Type II interaction site [polypeptide binding]"
                     /db_xref="CDD:260049"
     CDS             1..597
                     /gene="PIDD1"
                     /gene_synonym="LRDD; MRT75; PIDD"
                     /coded_by="XM_054369322.1:307..2100"
                     /db_xref="GeneID:55367"
                     /db_xref="HGNC:HGNC:16491"
                     /db_xref="MIM:605247"
ORIGIN      
        1 mprlfltsdl dsfpvtprgc svtlacgvrl qfpagatatp itiryrlllp epglvplgph
       61 dallshvlel qphgvafqqd vglwllftpp qarrcrevvv rtrndnswgd letyleeeap
      121 qrlwahcqvp hfswflvvsr pvsnaclvpp egtllcssgh pgvkvifppg ateeprrvsm
      181 qvvrmagrel qallgepeaa vspllclsqs gppsflqpvt vqlplpsgit glsldrsrlh
      241 llywappaat wdditaqvvl elthlyarfq vthfswywlw yttkncvggl arkawerlrl
      301 hrvnlialqr rrdpeqvllq clprnkvdat lrrlleryrg pepsdtvemf egeeffaafe
      361 rgidvdadrp dcvegricfv fyshlknvke vyvtttldre aqavrgqvsf yrgavpvrvp
      421 eeaeaarqrk gadalwmatl piklprlrgs egprrgagls laplnlgdae tgfltqsnll
      481 svagrlgldw pavalhlgvs yrevqrirhe frddldeqir hmlfswaerq agqpgavgll
      541 vqaleqsdrq dvaeevravl elgrrkyqds irrmglapkd palpgssapq ppepaqa
//
LOCUS       XP_054225298             391 aa            linear   PRI 05-AUG-2025
DEFINITION  lysosomal Pro-X carboxypeptidase isoform X1 [Homo sapiens].
ACCESSION   XP_054225298
VERSION     XP_054225298.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369323.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..391
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..391
                     /product="lysosomal Pro-X carboxypeptidase isoform X1"
                     /calculated_mol_wt=43803
     Region          1..372
                     /region_name="alpha/beta hydrolases"
                     /note="A functionally diverse superfamily containing
                     proteases, lipases, peroxidases, esterases, epoxide
                     hydrolases and dehalogenases. The catalytic apparatus
                     typically involves three residues (catalytic triad): a
                     serine, a glutamate or aspartate and a...; cl21494"
                     /db_xref="CDD:473884"
     CDS             1..391
                     /gene="PRCP"
                     /gene_synonym="HUMPCP; PCP"
                     /coded_by="XM_054369323.1:247..1422"
                     /db_xref="GeneID:5547"
                     /db_xref="HGNC:HGNC:9344"
                     /db_xref="MIM:176785"
ORIGIN      
        1 mwdvaeelka mlvfaehryy geslpfgdns fkdsrhlnfl tseqaladfa elikhlkrti
       61 pgaenqpvia iggsyggmla awfrmkyphm vvgalaasap iwqfedlvpc gvfmkivttd
      121 frksgphcse sihrswdain rlsntgsglq wltgalhlcs pltsqdiqhl kdwisetwvn
      181 lamvdypyas nflqplpawp ikvvcqylkn pnvsdslllq nifqalnvyy nysgqvkcln
      241 isetatsslg tlgwsyqact evvmpfctng vddmfephsw nlkelsddcf qqwgvrprps
      301 wittmyggkn isshtnivfs ngeldpwsgg gvtkditdtl vavtisegah hldlrtknal
      361 dpmsvllars levrhmknwi rdfydsagkq h
//
LOCUS       XP_054225299            1569 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase MRCK gamma isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225299
VERSION     XP_054225299.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369324.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1569
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1569
                     /product="serine/threonine-protein kinase MRCK gamma
                     isoform X1"
                     /calculated_mol_wt=174193
     Region          69..399
                     /region_name="STKc_DMPK_like"
                     /note="Catalytic domain of Myotonic Dystrophy protein
                     kinase (DMPK)-like Serine/Threonine Kinases; cd05597"
                     /db_xref="CDD:270748"
     Site            order(77..81,85,98,100,132,148..149,151,155,157,195,197,
                     199..200,202,212..213,216,231..236,268,274,277)
                     /site_type="active"
                     /db_xref="CDD:270748"
     Site            order(77..81,85,98,100,132,149..151,155,195,197,199..200,
                     202,212..213)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270748"
     Site            order(81,155,157,195,197,199,216,231..236,268,274,277)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270748"
     Site            order(212..222,225..236)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270748"
     Site            393..398
                     /site_type="other"
                     /note="hydrophobic motif (HM)"
                     /db_xref="CDD:270748"
     Region          <444..805
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          897..939
                     /region_name="C1_MRCKgamma"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in myotonic dystrophy kinase-related Cdc42-binding
                     kinase gamma (MRCK gamma) and similar proteins; cd20866"
                     /db_xref="CDD:410416"
     Site            order(902..908,916..920,923)
                     /site_type="other"
                     /note="putative DAG/PE binding site [chemical binding]"
                     /db_xref="CDD:410416"
     Region          956..1088
                     /region_name="PH_MRCK"
                     /note="MRCK (myotonic dystrophy-related Cdc42-binding
                     kinase) pleckstrin homology (PH) domain; cd01243"
                     /db_xref="CDD:269949"
     Region          1120..1378
                     /region_name="CNH"
                     /note="CNH domain; pfam00780"
                     /db_xref="CDD:459938"
     CDS             1..1569
                     /gene="CDC42BPG"
                     /gene_synonym="DMPK2; HSMDPKIN; KAPPA-200; MRCKG;
                     MRCKgamma"
                     /coded_by="XM_054369324.1:85..4794"
                     /db_xref="GeneID:55561"
                     /db_xref="HGNC:HGNC:29829"
                     /db_xref="MIM:613991"
ORIGIN      
        1 merrlraleq largeaggcp gldglldlll alhhelssgp lrrersvaqf lswaspfvsk
       61 vkelrlqrdd feilkvigrg afgevtvvrq rdtgqifamk mlhkwemlkr aetacfreer
      121 dvlvkgdsrw vttlhyafqd eeylylvmdy yaggdlltll srfedrlppe laqfylaemv
      181 laihslhqlg yvhrdvkpdn vlldvnghir ladfgsclrl ntngmvdssv avgtpdyisp
      241 eilqameegk ghygpqcdww slgvcayell fgetpfyaes lvetygkimn hedhlqfppd
      301 vpdvpasaqd lirqllcrqe erlgrggldd frnhpffegv dwerlassta pyipelrgpm
      361 dtsnfdvddd tlnhpgtlpp pshgafsghh lpfvgftyts gshspessse awaalerklq
      421 cleqekvels rkhqealhap tdhreleqlr kevqtlrdrl pemlrdkasl sqtdgppags
      481 pgqdsdlrqe ldrlhrelae graglqaqeq elcraqgqqe ellqrlqeaq ereaatasqt
      541 ralssqleea raaqreleaq vsslsrqvtq lqgqweqrle essqaktiht asetngmgpp
      601 eggpqeaqlr kevaalreql eqahshrpsg keealcqlqe enrrlsreqe rleaelaqeq
      661 eskqrleger retesnweaq ladilswvnd ekvsrgylqa latkmaeele slrnvgtqtl
      721 parpldhqwk arrlqkmeas arlelqsale aeirakqglq erltqvqeaq lqaerrlqea
      781 ekqsqalqqe lamlreelra rgpvdtkpsn slipflsfrs sekdsakdpg isgeatrhgg
      841 epdlrpegrr slrmgavfpr aptantaste glpakgwgmg pwealgngcp ppqpgshtlr
      901 prsfpsptkc lrctslmlgl grqglgcdac gyfchttcap qappcpvppd llrtalgvhp
      961 etgtgtayeg flsvprpsgv rrgwqrvfaa lsdsrlllfd apdlrlspps gallqvldlr
     1021 dpqfsatpvl asdvihaqsr dlprifrvtt sqlavppttc tvlllaeseg ererwlqvlg
     1081 elqrllldar prprpvytlk eaydnglpll phtlcaaild qdrlalgtee glfvihlrsn
     1141 difqvgecrr vqrltlspsa gllvvlcgrg psvrlfalae lenievagak ipesrgcqvl
     1201 aagsilqart pvlcvavkrq vlcyqlgpgp gpwqrrirel qapatvqslg llgdrlcvga
     1261 aggfalypll neaaplalga glvpeelpps rgglgealga velslsefll lfttagiyvd
     1321 gagrksrghe llwpaapmgw gyaapyltvf sensidvfdv rraewvqtvp lkkvrplnpe
     1381 gslflygtek vrltylrnql aekdefdipd ltdnsrrqlf rtkskrrfff rvseeqqkqq
     1441 rremlkdpfv rsklispptn fnhlvhvgpa ngrpgardks papeekgrva rgsgpqrphs
     1501 fsealrrpas mgseglggda dpmkrkpwts lssesvscpq gslspatslm qvserprslp
     1561 lspelessp
//
LOCUS       XP_054225300            1568 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase MRCK gamma isoform X2 [Homo
            sapiens].
ACCESSION   XP_054225300
VERSION     XP_054225300.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369325.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1568
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1568
                     /product="serine/threonine-protein kinase MRCK gamma
                     isoform X2"
                     /calculated_mol_wt=174065
     Region          69..399
                     /region_name="STKc_DMPK_like"
                     /note="Catalytic domain of Myotonic Dystrophy protein
                     kinase (DMPK)-like Serine/Threonine Kinases; cd05597"
                     /db_xref="CDD:270748"
     Site            order(77..81,85,98,100,132,148..149,151,155,157,195,197,
                     199..200,202,212..213,216,231..236,268,274,277)
                     /site_type="active"
                     /db_xref="CDD:270748"
     Site            order(77..81,85,98,100,132,149..151,155,195,197,199..200,
                     202,212..213)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270748"
     Site            order(81,155,157,195,197,199,216,231..236,268,274,277)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270748"
     Site            order(212..222,225..236)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270748"
     Site            393..398
                     /site_type="other"
                     /note="hydrophobic motif (HM)"
                     /db_xref="CDD:270748"
     Region          <444..805
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          896..938
                     /region_name="C1"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     superfamily; cl00040"
                     /db_xref="CDD:412127"
     Region          955..1087
                     /region_name="PH_MRCK"
                     /note="MRCK (myotonic dystrophy-related Cdc42-binding
                     kinase) pleckstrin homology (PH) domain; cd01243"
                     /db_xref="CDD:269949"
     Region          1119..1377
                     /region_name="CNH"
                     /note="CNH domain; pfam00780"
                     /db_xref="CDD:459938"
     CDS             1..1568
                     /gene="CDC42BPG"
                     /gene_synonym="DMPK2; HSMDPKIN; KAPPA-200; MRCKG;
                     MRCKgamma"
                     /coded_by="XM_054369325.1:85..4791"
                     /db_xref="GeneID:55561"
                     /db_xref="HGNC:HGNC:29829"
                     /db_xref="MIM:613991"
ORIGIN      
        1 merrlraleq largeaggcp gldglldlll alhhelssgp lrrersvaqf lswaspfvsk
       61 vkelrlqrdd feilkvigrg afgevtvvrq rdtgqifamk mlhkwemlkr aetacfreer
      121 dvlvkgdsrw vttlhyafqd eeylylvmdy yaggdlltll srfedrlppe laqfylaemv
      181 laihslhqlg yvhrdvkpdn vlldvnghir ladfgsclrl ntngmvdssv avgtpdyisp
      241 eilqameegk ghygpqcdww slgvcayell fgetpfyaes lvetygkimn hedhlqfppd
      301 vpdvpasaqd lirqllcrqe erlgrggldd frnhpffegv dwerlassta pyipelrgpm
      361 dtsnfdvddd tlnhpgtlpp pshgafsghh lpfvgftyts gshspessse awaalerklq
      421 cleqekvels rkhqealhap tdhreleqlr kevqtlrdrl pemlrdkasl sqtdgppags
      481 pgqdsdlrqe ldrlhrelae graglqaqeq elcraqgqqe ellqrlqeaq ereaatasqt
      541 ralssqleea raaqreleaq vsslsrqvtq lqgqweqrle essqaktiht asetngmgpp
      601 eggpqeaqlr kevaalreql eqahshrpsg keealcqlqe enrrlsreqe rleaelaqeq
      661 eskqrleger retesnweaq ladilswvnd ekvsrgylqa latkmaeele slrnvgtqtl
      721 parpldhqwk arrlqkmeas arlelqsale aeirakqglq erltqvqeaq lqaerrlqea
      781 ekqsqalqqe lamlreelra rgpvdtkpsn slipflsfrs sedsakdpgi sgeatrhgge
      841 pdlrpegrrs lrmgavfpra ptantasteg lpakgwgmgp wealgngcpp pqpgshtlrp
      901 rsfpsptkcl rctslmlglg rqglgcdacg yfchttcapq appcpvppdl lrtalgvhpe
      961 tgtgtayegf lsvprpsgvr rgwqrvfaal sdsrlllfda pdlrlsppsg allqvldlrd
     1021 pqfsatpvla sdvihaqsrd lprifrvtts qlavppttct vlllaesege rerwlqvlge
     1081 lqrllldarp rprpvytlke aydnglpllp htlcaaildq drlalgteeg lfvihlrsnd
     1141 ifqvgecrrv qrltlspsag llvvlcgrgp svrlfalael enievagaki pesrgcqvla
     1201 agsilqartp vlcvavkrqv lcyqlgpgpg pwqrrirelq apatvqslgl lgdrlcvgaa
     1261 ggfalyplln eaaplalgag lvpeelppsr gglgealgav elslseflll fttagiyvdg
     1321 agrksrghel lwpaapmgwg yaapyltvfs ensidvfdvr raewvqtvpl kkvrplnpeg
     1381 slflygtekv rltylrnqla ekdefdipdl tdnsrrqlfr tkskrrfffr vseeqqkqqr
     1441 remlkdpfvr sklispptnf nhlvhvgpan grpgardksp apeekgrvar gsgpqrphsf
     1501 sealrrpasm gseglggdad pmkrkpwtsl ssesvscpqg slspatslmq vserprslpl
     1561 spelessp
//
LOCUS       XP_054225301            1562 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase MRCK gamma isoform X3 [Homo
            sapiens].
ACCESSION   XP_054225301
VERSION     XP_054225301.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369326.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1562
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1562
                     /product="serine/threonine-protein kinase MRCK gamma
                     isoform X3"
                     /calculated_mol_wt=173473
     Region          69..399
                     /region_name="STKc_DMPK_like"
                     /note="Catalytic domain of Myotonic Dystrophy protein
                     kinase (DMPK)-like Serine/Threonine Kinases; cd05597"
                     /db_xref="CDD:270748"
     Site            order(77..81,85,98,100,132,148..149,151,155,157,195,197,
                     199..200,202,212..213,216,231..236,268,274,277)
                     /site_type="active"
                     /db_xref="CDD:270748"
     Site            order(77..81,85,98,100,132,149..151,155,195,197,199..200,
                     202,212..213)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270748"
     Site            order(81,155,157,195,197,199,216,231..236,268,274,277)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270748"
     Site            order(212..222,225..236)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270748"
     Site            393..398
                     /site_type="other"
                     /note="hydrophobic motif (HM)"
                     /db_xref="CDD:270748"
     Region          <425..798
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          890..932
                     /region_name="C1_MRCKgamma"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in myotonic dystrophy kinase-related Cdc42-binding
                     kinase gamma (MRCK gamma) and similar proteins; cd20866"
                     /db_xref="CDD:410416"
     Site            order(895..901,909..913,916)
                     /site_type="other"
                     /note="putative DAG/PE binding site [chemical binding]"
                     /db_xref="CDD:410416"
     Region          949..1081
                     /region_name="PH_MRCK"
                     /note="MRCK (myotonic dystrophy-related Cdc42-binding
                     kinase) pleckstrin homology (PH) domain; cd01243"
                     /db_xref="CDD:269949"
     Region          1113..1371
                     /region_name="CNH"
                     /note="CNH domain; pfam00780"
                     /db_xref="CDD:459938"
     CDS             1..1562
                     /gene="CDC42BPG"
                     /gene_synonym="DMPK2; HSMDPKIN; KAPPA-200; MRCKG;
                     MRCKgamma"
                     /coded_by="XM_054369326.1:85..4773"
                     /db_xref="GeneID:55561"
                     /db_xref="HGNC:HGNC:29829"
                     /db_xref="MIM:613991"
ORIGIN      
        1 merrlraleq largeaggcp gldglldlll alhhelssgp lrrersvaqf lswaspfvsk
       61 vkelrlqrdd feilkvigrg afgevtvvrq rdtgqifamk mlhkwemlkr aetacfreer
      121 dvlvkgdsrw vttlhyafqd eeylylvmdy yaggdlltll srfedrlppe laqfylaemv
      181 laihslhqlg yvhrdvkpdn vlldvnghir ladfgsclrl ntngmvdssv avgtpdyisp
      241 eilqameegk ghygpqcdww slgvcayell fgetpfyaes lvetygkimn hedhlqfppd
      301 vpdvpasaqd lirqllcrqe erlgrggldd frnhpffegv dwerlassta pyipelrgpm
      361 dtsnfdvddd tlnhpgtlpp pshgafsghh lpfvgftyts gshspessse awaalerklq
      421 cleqekvels rkhqdhrele qlrkevqtlr drlpemlrdk aslsqtdgpp agspgqdsdl
      481 rqeldrlhre laegraglqa qeqelcraqg qqeellqrlq eaqereaata sqtralssql
      541 eearaaqrel eaqvsslsrq vtqlqgqweq rleessqakt ihtasetngm gppeggpqea
      601 qlrkevaalr eqleqahshr psgkeealcq lqeenrrlsr eqerleaela qeqeskqrle
      661 gerretesnw eaqladilsw vndekvsrgy lqalatkmae eleslrnvgt qtlparpldh
      721 qwkarrlqkm easarlelqs aleaeirakq glqerltqvq eaqlqaerrl qeaekqsqal
      781 qqelamlree lrargpvdtk psnslipfls frssekdsak dpgisgeatr hggepdlrpe
      841 grrslrmgav fpraptanta steglpakgw gmgpwealgn gcpppqpgsh tlrprsfpsp
      901 tkclrctslm lglgrqglgc dacgyfchtt capqappcpv ppdllrtalg vhpetgtgta
      961 yegflsvprp sgvrrgwqrv faalsdsrll lfdapdlrls ppsgallqvl dlrdpqfsat
     1021 pvlasdviha qsrdlprifr vttsqlavpp ttctvlllae segererwlq vlgelqrlll
     1081 darprprpvy tlkeaydngl pllphtlcaa ildqdrlalg teeglfvihl rsndifqvge
     1141 crrvqrltls psagllvvlc grgpsvrlfa laelenieva gakipesrgc qvlaagsilq
     1201 artpvlcvav krqvlcyqlg pgpgpwqrri relqapatvq slgllgdrlc vgaaggfaly
     1261 pllneaapla lgaglvpeel ppsrgglgea lgavelslse flllfttagi yvdgagrksr
     1321 ghellwpaap mgwgyaapyl tvfsensidv fdvrraewvq tvplkkvrpl npegslflyg
     1381 tekvrltylr nqlaekdefd ipdltdnsrr qlfrtkskrr fffrvseeqq kqqrremlkd
     1441 pfvrsklisp ptnfnhlvhv gpangrpgar dkspapeekg rvargsgpqr phsfsealrr
     1501 pasmgseglg gdadpmkrkp wtslssesvs cpqgslspat slmqvserpr slplspeles
     1561 sp
//
LOCUS       XP_054225302            1544 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase MRCK gamma isoform X4 [Homo
            sapiens].
ACCESSION   XP_054225302
VERSION     XP_054225302.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369327.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1544
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1544
                     /product="serine/threonine-protein kinase MRCK gamma
                     isoform X4"
                     /calculated_mol_wt=171637
     Region          69..399
                     /region_name="STKc_DMPK_like"
                     /note="Catalytic domain of Myotonic Dystrophy protein
                     kinase (DMPK)-like Serine/Threonine Kinases; cd05597"
                     /db_xref="CDD:270748"
     Site            order(77..81,85,98,100,132,148..149,151,155,157,195,197,
                     199..200,202,212..213,216,231..236,268,274,277)
                     /site_type="active"
                     /db_xref="CDD:270748"
     Site            order(77..81,85,98,100,132,149..151,155,195,197,199..200,
                     202,212..213)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270748"
     Site            order(81,155,157,195,197,199,216,231..236,268,274,277)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270748"
     Site            order(212..222,225..236)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270748"
     Site            393..398
                     /site_type="other"
                     /note="hydrophobic motif (HM)"
                     /db_xref="CDD:270748"
     Region          <425..798
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          872..914
                     /region_name="C1_MRCKgamma"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in myotonic dystrophy kinase-related Cdc42-binding
                     kinase gamma (MRCK gamma) and similar proteins; cd20866"
                     /db_xref="CDD:410416"
     Site            order(877..883,891..895,898)
                     /site_type="other"
                     /note="putative DAG/PE binding site [chemical binding]"
                     /db_xref="CDD:410416"
     Region          931..1063
                     /region_name="PH_MRCK"
                     /note="MRCK (myotonic dystrophy-related Cdc42-binding
                     kinase) pleckstrin homology (PH) domain; cd01243"
                     /db_xref="CDD:269949"
     Region          1095..1353
                     /region_name="CNH"
                     /note="CNH domain; pfam00780"
                     /db_xref="CDD:459938"
     CDS             1..1544
                     /gene="CDC42BPG"
                     /gene_synonym="DMPK2; HSMDPKIN; KAPPA-200; MRCKG;
                     MRCKgamma"
                     /coded_by="XM_054369327.1:85..4719"
                     /db_xref="GeneID:55561"
                     /db_xref="HGNC:HGNC:29829"
                     /db_xref="MIM:613991"
ORIGIN      
        1 merrlraleq largeaggcp gldglldlll alhhelssgp lrrersvaqf lswaspfvsk
       61 vkelrlqrdd feilkvigrg afgevtvvrq rdtgqifamk mlhkwemlkr aetacfreer
      121 dvlvkgdsrw vttlhyafqd eeylylvmdy yaggdlltll srfedrlppe laqfylaemv
      181 laihslhqlg yvhrdvkpdn vlldvnghir ladfgsclrl ntngmvdssv avgtpdyisp
      241 eilqameegk ghygpqcdww slgvcayell fgetpfyaes lvetygkimn hedhlqfppd
      301 vpdvpasaqd lirqllcrqe erlgrggldd frnhpffegv dwerlassta pyipelrgpm
      361 dtsnfdvddd tlnhpgtlpp pshgafsghh lpfvgftyts gshspessse awaalerklq
      421 cleqekvels rkhqdhrele qlrkevqtlr drlpemlrdk aslsqtdgpp agspgqdsdl
      481 rqeldrlhre laegraglqa qeqelcraqg qqeellqrlq eaqereaata sqtralssql
      541 eearaaqrel eaqvsslsrq vtqlqgqweq rleessqakt ihtasetngm gppeggpqea
      601 qlrkevaalr eqleqahshr psgkeealcq lqeenrrlsr eqerleaela qeqeskqrle
      661 gerretesnw eaqladilsw vndekvsrgy lqalatkmae eleslrnvgt qtlparpldh
      721 qwkarrlqkm easarlelqs aleaeirakq glqerltqvq eaqlqaerrl qeaekqsqal
      781 qqelamlree lrargpvdtk psnslipfls frssekdsak dpgisgeatr hggepdlrpe
      841 grrslrmgav fpraptanta steglpakpg shtlrprsfp sptkclrcts lmlglgrqgl
      901 gcdacgyfch ttcapqappc pvppdllrta lgvhpetgtg tayegflsvp rpsgvrrgwq
      961 rvfaalsdsr lllfdapdlr lsppsgallq vldlrdpqfs atpvlasdvi haqsrdlpri
     1021 frvttsqlav ppttctvlll aesegererw lqvlgelqrl lldarprprp vytlkeaydn
     1081 glpllphtlc aaildqdrla lgteeglfvi hlrsndifqv gecrrvqrlt lspsagllvv
     1141 lcgrgpsvrl falaelenie vagakipesr gcqvlaagsi lqartpvlcv avkrqvlcyq
     1201 lgpgpgpwqr rirelqapat vqslgllgdr lcvgaaggfa lypllneaap lalgaglvpe
     1261 elppsrgglg ealgavelsl seflllftta giyvdgagrk srghellwpa apmgwgyaap
     1321 yltvfsensi dvfdvrraew vqtvplkkvr plnpegslfl ygtekvrlty lrnqlaekde
     1381 fdipdltdns rrqlfrtksk rrfffrvsee qqkqqrreml kdpfvrskli spptnfnhlv
     1441 hvgpangrpg ardkspapee kgrvargsgp qrphsfseal rrpasmgseg lggdadpmkr
     1501 kpwtslsses vscpqgslsp atslmqvser prslplspel essp
//
LOCUS       XP_054225303            1530 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase MRCK gamma isoform X5 [Homo
            sapiens].
ACCESSION   XP_054225303
VERSION     XP_054225303.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369328.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1530
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1530
                     /product="serine/threonine-protein kinase MRCK gamma
                     isoform X5"
                     /calculated_mol_wt=168783
     Region          69..399
                     /region_name="STKc_DMPK_like"
                     /note="Catalytic domain of Myotonic Dystrophy protein
                     kinase (DMPK)-like Serine/Threonine Kinases; cd05597"
                     /db_xref="CDD:270748"
     Site            order(77..81,85,98,100,132,148..149,151,155,157,195,197,
                     199..200,202,212..213,216,231..236,268,274,277)
                     /site_type="active"
                     /db_xref="CDD:270748"
     Site            order(77..81,85,98,100,132,149..151,155,195,197,199..200,
                     202,212..213)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270748"
     Site            order(81,155,157,195,197,199,216,231..236,268,274,277)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270748"
     Site            order(212..222,225..236)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270748"
     Site            393..398
                     /site_type="other"
                     /note="hydrophobic motif (HM)"
                     /db_xref="CDD:270748"
     Region          <444..805
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          897..939
                     /region_name="C1"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     superfamily; cl00040"
                     /db_xref="CDD:412127"
     Region          956..1088
                     /region_name="PH_MRCK"
                     /note="MRCK (myotonic dystrophy-related Cdc42-binding
                     kinase) pleckstrin homology (PH) domain; cd01243"
                     /db_xref="CDD:269949"
     Region          1120..1340
                     /region_name="CNH"
                     /note="CNH domain; cl02434"
                     /db_xref="CDD:470577"
     CDS             1..1530
                     /gene="CDC42BPG"
                     /gene_synonym="DMPK2; HSMDPKIN; KAPPA-200; MRCKG;
                     MRCKgamma"
                     /coded_by="XM_054369328.1:85..4677"
                     /db_xref="GeneID:55561"
                     /db_xref="HGNC:HGNC:29829"
                     /db_xref="MIM:613991"
ORIGIN      
        1 merrlraleq largeaggcp gldglldlll alhhelssgp lrrersvaqf lswaspfvsk
       61 vkelrlqrdd feilkvigrg afgevtvvrq rdtgqifamk mlhkwemlkr aetacfreer
      121 dvlvkgdsrw vttlhyafqd eeylylvmdy yaggdlltll srfedrlppe laqfylaemv
      181 laihslhqlg yvhrdvkpdn vlldvnghir ladfgsclrl ntngmvdssv avgtpdyisp
      241 eilqameegk ghygpqcdww slgvcayell fgetpfyaes lvetygkimn hedhlqfppd
      301 vpdvpasaqd lirqllcrqe erlgrggldd frnhpffegv dwerlassta pyipelrgpm
      361 dtsnfdvddd tlnhpgtlpp pshgafsghh lpfvgftyts gshspessse awaalerklq
      421 cleqekvels rkhqealhap tdhreleqlr kevqtlrdrl pemlrdkasl sqtdgppags
      481 pgqdsdlrqe ldrlhrelae graglqaqeq elcraqgqqe ellqrlqeaq ereaatasqt
      541 ralssqleea raaqreleaq vsslsrqvtq lqgqweqrle essqaktiht asetngmgpp
      601 eggpqeaqlr kevaalreql eqahshrpsg keealcqlqe enrrlsreqe rleaelaqeq
      661 eskqrleger retesnweaq ladilswvnd ekvsrgylqa latkmaeele slrnvgtqtl
      721 parpldhqwk arrlqkmeas arlelqsale aeirakqglq erltqvqeaq lqaerrlqea
      781 ekqsqalqqe lamlreelra rgpvdtkpsn slipflsfrs sekdsakdpg isgeatrhgg
      841 epdlrpegrr slrmgavfpr aptantaste glpakgwgmg pwealgngcp ppqpgshtlr
      901 prsfpsptkc lrctslmlgl grqglgcdac gyfchttcap qappcpvppd llrtalgvhp
      961 etgtgtayeg flsvprpsgv rrgwqrvfaa lsdsrlllfd apdlrlspps gallqvldlr
     1021 dpqfsatpvl asdvihaqsr dlprifrvtt sqlavppttc tvlllaeseg ererwlqvlg
     1081 elqrllldar prprpvytlk eaydnglpll phtlcaaild qdrlalgtee glfvihlrsn
     1141 difqvgecrr vqrltlspsa gllvvlcgrg psvrlfalae lenievagak ipesrgcqvl
     1201 aagsilqart pvlcvavkrq vlcyqlgpgp gpwqrrirel qapatvqslg llgdrlcvga
     1261 aggfalypll neaaplalga glvpeelpps rgglgealga velslsefll lfttagiyvd
     1321 gagrksrghe llwpaapmgw gaapqsrglp vplrhregpp dlpqepagre grvrhpgphr
     1381 qqpapavphq eqapllfprv ggaaeaaaqg daegpfcalq ahlaayqlqp pstrgpcqra
     1441 arrqgqvpgs rregpscprl rptaapqllr gvaapslhgq rrprwrrrph eeetldipvq
     1501 rvcvlppgia epcnlpnagl rtapkpppvp
//
LOCUS       XP_054225304            1512 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase MRCK gamma isoform X6 [Homo
            sapiens].
ACCESSION   XP_054225304
VERSION     XP_054225304.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369329.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1512
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1512
                     /product="serine/threonine-protein kinase MRCK gamma
                     isoform X6"
                     /calculated_mol_wt=166947
     Region          69..399
                     /region_name="STKc_DMPK_like"
                     /note="Catalytic domain of Myotonic Dystrophy protein
                     kinase (DMPK)-like Serine/Threonine Kinases; cd05597"
                     /db_xref="CDD:270748"
     Site            order(77..81,85,98,100,132,148..149,151,155,157,195,197,
                     199..200,202,212..213,216,231..236,268,274,277)
                     /site_type="active"
                     /db_xref="CDD:270748"
     Site            order(77..81,85,98,100,132,149..151,155,195,197,199..200,
                     202,212..213)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270748"
     Site            order(81,155,157,195,197,199,216,231..236,268,274,277)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270748"
     Site            order(212..222,225..236)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270748"
     Site            393..398
                     /site_type="other"
                     /note="hydrophobic motif (HM)"
                     /db_xref="CDD:270748"
     Region          <444..805
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          879..921
                     /region_name="C1"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     superfamily; cl00040"
                     /db_xref="CDD:412127"
     Region          938..1070
                     /region_name="PH_MRCK"
                     /note="MRCK (myotonic dystrophy-related Cdc42-binding
                     kinase) pleckstrin homology (PH) domain; cd01243"
                     /db_xref="CDD:269949"
     Region          1102..1322
                     /region_name="CNH"
                     /note="CNH domain; cl02434"
                     /db_xref="CDD:470577"
     CDS             1..1512
                     /gene="CDC42BPG"
                     /gene_synonym="DMPK2; HSMDPKIN; KAPPA-200; MRCKG;
                     MRCKgamma"
                     /coded_by="XM_054369329.1:85..4623"
                     /db_xref="GeneID:55561"
                     /db_xref="HGNC:HGNC:29829"
                     /db_xref="MIM:613991"
ORIGIN      
        1 merrlraleq largeaggcp gldglldlll alhhelssgp lrrersvaqf lswaspfvsk
       61 vkelrlqrdd feilkvigrg afgevtvvrq rdtgqifamk mlhkwemlkr aetacfreer
      121 dvlvkgdsrw vttlhyafqd eeylylvmdy yaggdlltll srfedrlppe laqfylaemv
      181 laihslhqlg yvhrdvkpdn vlldvnghir ladfgsclrl ntngmvdssv avgtpdyisp
      241 eilqameegk ghygpqcdww slgvcayell fgetpfyaes lvetygkimn hedhlqfppd
      301 vpdvpasaqd lirqllcrqe erlgrggldd frnhpffegv dwerlassta pyipelrgpm
      361 dtsnfdvddd tlnhpgtlpp pshgafsghh lpfvgftyts gshspessse awaalerklq
      421 cleqekvels rkhqealhap tdhreleqlr kevqtlrdrl pemlrdkasl sqtdgppags
      481 pgqdsdlrqe ldrlhrelae graglqaqeq elcraqgqqe ellqrlqeaq ereaatasqt
      541 ralssqleea raaqreleaq vsslsrqvtq lqgqweqrle essqaktiht asetngmgpp
      601 eggpqeaqlr kevaalreql eqahshrpsg keealcqlqe enrrlsreqe rleaelaqeq
      661 eskqrleger retesnweaq ladilswvnd ekvsrgylqa latkmaeele slrnvgtqtl
      721 parpldhqwk arrlqkmeas arlelqsale aeirakqglq erltqvqeaq lqaerrlqea
      781 ekqsqalqqe lamlreelra rgpvdtkpsn slipflsfrs sekdsakdpg isgeatrhgg
      841 epdlrpegrr slrmgavfpr aptantaste glpakpgsht lrprsfpspt kclrctslml
      901 glgrqglgcd acgyfchttc apqappcpvp pdllrtalgv hpetgtgtay egflsvprps
      961 gvrrgwqrvf aalsdsrlll fdapdlrlsp psgallqvld lrdpqfsatp vlasdvihaq
     1021 srdlprifrv ttsqlavppt tctvlllaes egererwlqv lgelqrllld arprprpvyt
     1081 lkeaydnglp llphtlcaai ldqdrlalgt eeglfvihlr sndifqvgec rrvqrltlsp
     1141 sagllvvlcg rgpsvrlfal aelenievag akipesrgcq vlaagsilqa rtpvlcvavk
     1201 rqvlcyqlgp gpgpwqrrir elqapatvqs lgllgdrlcv gaaggfalyp llneaaplal
     1261 gaglvpeelp psrgglgeal gavelslsef lllfttagiy vdgagrksrg hellwpaapm
     1321 gwgaapqsrg lpvplrhreg ppdlpqepag regrvrhpgp hrqqpapavp hqeqapllfp
     1381 rvggaaeaaa qgdaegpfca lqahlaayql qppstrgpcq raarrqgqvp gsrregpscp
     1441 rlrptaapql lrgvaapslh gqrrprwrrr pheeetldip vqrvcvlppg iaepcnlpna
     1501 glrtapkppp vp
//
LOCUS       XP_054225305            1505 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase MRCK gamma isoform X7 [Homo
            sapiens].
ACCESSION   XP_054225305
VERSION     XP_054225305.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369330.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1505
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1505
                     /product="serine/threonine-protein kinase MRCK gamma
                     isoform X7"
                     /calculated_mol_wt=166227
     Region          69..399
                     /region_name="STKc_DMPK_like"
                     /note="Catalytic domain of Myotonic Dystrophy protein
                     kinase (DMPK)-like Serine/Threonine Kinases; cd05597"
                     /db_xref="CDD:270748"
     Site            order(77..81,85,98,100,132,148..149,151,155,157,195,197,
                     199..200,202,212..213,216,231..236,268,274,277)
                     /site_type="active"
                     /db_xref="CDD:270748"
     Site            order(77..81,85,98,100,132,149..151,155,195,197,199..200,
                     202,212..213)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270748"
     Site            order(81,155,157,195,197,199,216,231..236,268,274,277)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270748"
     Site            order(212..222,225..236)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270748"
     Site            393..398
                     /site_type="other"
                     /note="hydrophobic motif (HM)"
                     /db_xref="CDD:270748"
     Region          <425..798
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          872..914
                     /region_name="C1"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     superfamily; cl00040"
                     /db_xref="CDD:412127"
     Region          931..1063
                     /region_name="PH_MRCK"
                     /note="MRCK (myotonic dystrophy-related Cdc42-binding
                     kinase) pleckstrin homology (PH) domain; cd01243"
                     /db_xref="CDD:269949"
     Region          1095..1315
                     /region_name="CNH"
                     /note="CNH domain; cl02434"
                     /db_xref="CDD:470577"
     CDS             1..1505
                     /gene="CDC42BPG"
                     /gene_synonym="DMPK2; HSMDPKIN; KAPPA-200; MRCKG;
                     MRCKgamma"
                     /coded_by="XM_054369330.1:85..4602"
                     /db_xref="GeneID:55561"
                     /db_xref="HGNC:HGNC:29829"
                     /db_xref="MIM:613991"
ORIGIN      
        1 merrlraleq largeaggcp gldglldlll alhhelssgp lrrersvaqf lswaspfvsk
       61 vkelrlqrdd feilkvigrg afgevtvvrq rdtgqifamk mlhkwemlkr aetacfreer
      121 dvlvkgdsrw vttlhyafqd eeylylvmdy yaggdlltll srfedrlppe laqfylaemv
      181 laihslhqlg yvhrdvkpdn vlldvnghir ladfgsclrl ntngmvdssv avgtpdyisp
      241 eilqameegk ghygpqcdww slgvcayell fgetpfyaes lvetygkimn hedhlqfppd
      301 vpdvpasaqd lirqllcrqe erlgrggldd frnhpffegv dwerlassta pyipelrgpm
      361 dtsnfdvddd tlnhpgtlpp pshgafsghh lpfvgftyts gshspessse awaalerklq
      421 cleqekvels rkhqdhrele qlrkevqtlr drlpemlrdk aslsqtdgpp agspgqdsdl
      481 rqeldrlhre laegraglqa qeqelcraqg qqeellqrlq eaqereaata sqtralssql
      541 eearaaqrel eaqvsslsrq vtqlqgqweq rleessqakt ihtasetngm gppeggpqea
      601 qlrkevaalr eqleqahshr psgkeealcq lqeenrrlsr eqerleaela qeqeskqrle
      661 gerretesnw eaqladilsw vndekvsrgy lqalatkmae eleslrnvgt qtlparpldh
      721 qwkarrlqkm easarlelqs aleaeirakq glqerltqvq eaqlqaerrl qeaekqsqal
      781 qqelamlree lrargpvdtk psnslipfls frssekdsak dpgisgeatr hggepdlrpe
      841 grrslrmgav fpraptanta steglpakpg shtlrprsfp sptkclrcts lmlglgrqgl
      901 gcdacgyfch ttcapqappc pvppdllrta lgvhpetgtg tayegflsvp rpsgvrrgwq
      961 rvfaalsdsr lllfdapdlr lsppsgallq vldlrdpqfs atpvlasdvi haqsrdlpri
     1021 frvttsqlav ppttctvlll aesegererw lqvlgelqrl lldarprprp vytlkeaydn
     1081 glpllphtlc aaildqdrla lgteeglfvi hlrsndifqv gecrrvqrlt lspsagllvv
     1141 lcgrgpsvrl falaelenie vagakipesr gcqvlaagsi lqartpvlcv avkrqvlcyq
     1201 lgpgpgpwqr rirelqapat vqslgllgdr lcvgaaggfa lypllneaap lalgaglvpe
     1261 elppsrgglg ealgavelsl seflllftta giyvdgagrk srghellwpa apmgwgaapq
     1321 srglpvplrh regppdlpqe pagregrvrh pgphrqqpap avphqeqapl lfprvggaae
     1381 aaaqgdaegp fcalqahlaa yqlqppstrg pcqraarrqg qvpgsrregp scprlrptaa
     1441 pqllrgvaap slhgqrrprw rrrpheeetl dipvqrvcvl ppgiaepcnl pnaglrtapk
     1501 pppvp
//
LOCUS       XP_054225306            1495 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase MRCK gamma isoform X8 [Homo
            sapiens].
ACCESSION   XP_054225306
VERSION     XP_054225306.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369331.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1495
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1495
                     /product="serine/threonine-protein kinase MRCK gamma
                     isoform X8"
                     /calculated_mol_wt=164835
     Region          69..399
                     /region_name="STKc_DMPK_like"
                     /note="Catalytic domain of Myotonic Dystrophy protein
                     kinase (DMPK)-like Serine/Threonine Kinases; cd05597"
                     /db_xref="CDD:270748"
     Site            order(77..81,85,98,100,132,148..149,151,155,157,195,197,
                     199..200,202,212..213,216,231..236,268,274,277)
                     /site_type="active"
                     /db_xref="CDD:270748"
     Site            order(77..81,85,98,100,132,149..151,155,195,197,199..200,
                     202,212..213)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270748"
     Site            order(81,155,157,195,197,199,216,231..236,268,274,277)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270748"
     Site            order(212..222,225..236)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270748"
     Site            393..398
                     /site_type="other"
                     /note="hydrophobic motif (HM)"
                     /db_xref="CDD:270748"
     Region          <444..805
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          897..939
                     /region_name="C1"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     superfamily; cl00040"
                     /db_xref="CDD:412127"
     Region          956..1088
                     /region_name="PH_MRCK"
                     /note="MRCK (myotonic dystrophy-related Cdc42-binding
                     kinase) pleckstrin homology (PH) domain; cd01243"
                     /db_xref="CDD:269949"
     Region          1120..1340
                     /region_name="CNH"
                     /note="CNH domain; cl02434"
                     /db_xref="CDD:470577"
     CDS             1..1495
                     /gene="CDC42BPG"
                     /gene_synonym="DMPK2; HSMDPKIN; KAPPA-200; MRCKG;
                     MRCKgamma"
                     /coded_by="XM_054369331.1:85..4572"
                     /db_xref="GeneID:55561"
                     /db_xref="HGNC:HGNC:29829"
                     /db_xref="MIM:613991"
ORIGIN      
        1 merrlraleq largeaggcp gldglldlll alhhelssgp lrrersvaqf lswaspfvsk
       61 vkelrlqrdd feilkvigrg afgevtvvrq rdtgqifamk mlhkwemlkr aetacfreer
      121 dvlvkgdsrw vttlhyafqd eeylylvmdy yaggdlltll srfedrlppe laqfylaemv
      181 laihslhqlg yvhrdvkpdn vlldvnghir ladfgsclrl ntngmvdssv avgtpdyisp
      241 eilqameegk ghygpqcdww slgvcayell fgetpfyaes lvetygkimn hedhlqfppd
      301 vpdvpasaqd lirqllcrqe erlgrggldd frnhpffegv dwerlassta pyipelrgpm
      361 dtsnfdvddd tlnhpgtlpp pshgafsghh lpfvgftyts gshspessse awaalerklq
      421 cleqekvels rkhqealhap tdhreleqlr kevqtlrdrl pemlrdkasl sqtdgppags
      481 pgqdsdlrqe ldrlhrelae graglqaqeq elcraqgqqe ellqrlqeaq ereaatasqt
      541 ralssqleea raaqreleaq vsslsrqvtq lqgqweqrle essqaktiht asetngmgpp
      601 eggpqeaqlr kevaalreql eqahshrpsg keealcqlqe enrrlsreqe rleaelaqeq
      661 eskqrleger retesnweaq ladilswvnd ekvsrgylqa latkmaeele slrnvgtqtl
      721 parpldhqwk arrlqkmeas arlelqsale aeirakqglq erltqvqeaq lqaerrlqea
      781 ekqsqalqqe lamlreelra rgpvdtkpsn slipflsfrs sekdsakdpg isgeatrhgg
      841 epdlrpegrr slrmgavfpr aptantaste glpakgwgmg pwealgngcp ppqpgshtlr
      901 prsfpsptkc lrctslmlgl grqglgcdac gyfchttcap qappcpvppd llrtalgvhp
      961 etgtgtayeg flsvprpsgv rrgwqrvfaa lsdsrlllfd apdlrlspps gallqvldlr
     1021 dpqfsatpvl asdvihaqsr dlprifrvtt sqlavppttc tvlllaeseg ererwlqvlg
     1081 elqrllldar prprpvytlk eaydnglpll phtlcaaild qdrlalgtee glfvihlrsn
     1141 difqvgecrr vqrltlspsa gllvvlcgrg psvrlfalae lenievagak ipesrgcqvl
     1201 aagsilqart pvlcvavkrq vlcyqlgpgp gpwqrrirel qapatvqslg llgdrlcvga
     1261 aggfalypll neaaplalga glvpeelpps rgglgealga velslsefll lfttagiyvd
     1321 gagrksrghe llwpaapmgw gaapqsrglp vplrhregpp dlpqepagre grvrhpgphr
     1381 qqpapavphq eqapllfprv ggaaeaaaqg daegpfcalq ahlaayqlqp pstrgpcqra
     1441 arrqgqvpvk rkpwtslsse svscpqgsls patslmqvse rprslplspe lessp
//
LOCUS       XP_054225307            1481 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase MRCK gamma isoform X9 [Homo
            sapiens].
ACCESSION   XP_054225307
VERSION     XP_054225307.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369332.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1481
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1481
                     /product="serine/threonine-protein kinase MRCK gamma
                     isoform X9"
                     /calculated_mol_wt=164924
     Region          69..399
                     /region_name="STKc_DMPK_like"
                     /note="Catalytic domain of Myotonic Dystrophy protein
                     kinase (DMPK)-like Serine/Threonine Kinases; cd05597"
                     /db_xref="CDD:270748"
     Site            order(77..81,85,98,100,132,148..149,151,155,157,195,197,
                     199..200,202,212..213,216,231..236,268,274,277)
                     /site_type="active"
                     /db_xref="CDD:270748"
     Site            order(77..81,85,98,100,132,149..151,155,195,197,199..200,
                     202,212..213)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270748"
     Site            order(81,155,157,195,197,199,216,231..236,268,274,277)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270748"
     Site            order(212..222,225..236)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270748"
     Site            393..398
                     /site_type="other"
                     /note="hydrophobic motif (HM)"
                     /db_xref="CDD:270748"
     Region          <444..805
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          897..939
                     /region_name="C1_MRCKgamma"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in myotonic dystrophy kinase-related Cdc42-binding
                     kinase gamma (MRCK gamma) and similar proteins; cd20866"
                     /db_xref="CDD:410416"
     Site            order(902..908,916..920,923)
                     /site_type="other"
                     /note="putative DAG/PE binding site [chemical binding]"
                     /db_xref="CDD:410416"
     Region          956..1088
                     /region_name="PH_MRCK"
                     /note="MRCK (myotonic dystrophy-related Cdc42-binding
                     kinase) pleckstrin homology (PH) domain; cd01243"
                     /db_xref="CDD:269949"
     Region          1120..1378
                     /region_name="CNH"
                     /note="CNH domain; pfam00780"
                     /db_xref="CDD:459938"
     CDS             1..1481
                     /gene="CDC42BPG"
                     /gene_synonym="DMPK2; HSMDPKIN; KAPPA-200; MRCKG;
                     MRCKgamma"
                     /coded_by="XM_054369332.1:85..4530"
                     /db_xref="GeneID:55561"
                     /db_xref="HGNC:HGNC:29829"
                     /db_xref="MIM:613991"
ORIGIN      
        1 merrlraleq largeaggcp gldglldlll alhhelssgp lrrersvaqf lswaspfvsk
       61 vkelrlqrdd feilkvigrg afgevtvvrq rdtgqifamk mlhkwemlkr aetacfreer
      121 dvlvkgdsrw vttlhyafqd eeylylvmdy yaggdlltll srfedrlppe laqfylaemv
      181 laihslhqlg yvhrdvkpdn vlldvnghir ladfgsclrl ntngmvdssv avgtpdyisp
      241 eilqameegk ghygpqcdww slgvcayell fgetpfyaes lvetygkimn hedhlqfppd
      301 vpdvpasaqd lirqllcrqe erlgrggldd frnhpffegv dwerlassta pyipelrgpm
      361 dtsnfdvddd tlnhpgtlpp pshgafsghh lpfvgftyts gshspessse awaalerklq
      421 cleqekvels rkhqealhap tdhreleqlr kevqtlrdrl pemlrdkasl sqtdgppags
      481 pgqdsdlrqe ldrlhrelae graglqaqeq elcraqgqqe ellqrlqeaq ereaatasqt
      541 ralssqleea raaqreleaq vsslsrqvtq lqgqweqrle essqaktiht asetngmgpp
      601 eggpqeaqlr kevaalreql eqahshrpsg keealcqlqe enrrlsreqe rleaelaqeq
      661 eskqrleger retesnweaq ladilswvnd ekvsrgylqa latkmaeele slrnvgtqtl
      721 parpldhqwk arrlqkmeas arlelqsale aeirakqglq erltqvqeaq lqaerrlqea
      781 ekqsqalqqe lamlreelra rgpvdtkpsn slipflsfrs sekdsakdpg isgeatrhgg
      841 epdlrpegrr slrmgavfpr aptantaste glpakgwgmg pwealgngcp ppqpgshtlr
      901 prsfpsptkc lrctslmlgl grqglgcdac gyfchttcap qappcpvppd llrtalgvhp
      961 etgtgtayeg flsvprpsgv rrgwqrvfaa lsdsrlllfd apdlrlspps gallqvldlr
     1021 dpqfsatpvl asdvihaqsr dlprifrvtt sqlavppttc tvlllaeseg ererwlqvlg
     1081 elqrllldar prprpvytlk eaydnglpll phtlcaaild qdrlalgtee glfvihlrsn
     1141 difqvgecrr vqrltlspsa gllvvlcgrg psvrlfalae lenievagak ipesrgcqvl
     1201 aagsilqart pvlcvavkrq vlcyqlgpgp gpwqrrirel qapatvqslg llgdrlcvga
     1261 aggfalypll neaaplalga glvpeelpps rgglgealga velslsefll lfttagiyvd
     1321 gagrksrghe llwpaapmgw gyaapyltvf sensidvfdv rraewvqtvp lkkvrplnpe
     1381 gslflygtek vrltylrnql aekdefdipd ltdnsrrqlf rtkskrrfff rvseeqqkqq
     1441 rremlkdpfv rsklispptn fnhlvhvgpa ngrpgardks p
//
LOCUS       XP_054225308            1471 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase MRCK gamma isoform X10 [Homo
            sapiens].
ACCESSION   XP_054225308
VERSION     XP_054225308.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369333.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 3% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1471
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1471
                     /product="serine/threonine-protein kinase MRCK gamma
                     isoform X10"
                     /calculated_mol_wt=163255
     Region          1..301
                     /region_name="STKc_DMPK_like"
                     /note="Catalytic domain of Myotonic Dystrophy protein
                     kinase (DMPK)-like Serine/Threonine Kinases; cd05597"
                     /db_xref="CDD:270748"
     Site            order(57,59,97,99,101,118,133..138,170,176,179)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270748"
     Site            order(114..124,127..138)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270748"
     Site            295..300
                     /site_type="other"
                     /note="hydrophobic motif (HM)"
                     /db_xref="CDD:270748"
     Region          <346..707
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          799..841
                     /region_name="C1"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     superfamily; cl00040"
                     /db_xref="CDD:412127"
     Region          858..990
                     /region_name="PH_MRCK"
                     /note="MRCK (myotonic dystrophy-related Cdc42-binding
                     kinase) pleckstrin homology (PH) domain; cd01243"
                     /db_xref="CDD:269949"
     Region          1022..1280
                     /region_name="CNH"
                     /note="CNH domain; pfam00780"
                     /db_xref="CDD:459938"
     CDS             1..1471
                     /gene="CDC42BPG"
                     /gene_synonym="DMPK2; HSMDPKIN; KAPPA-200; MRCKG;
                     MRCKgamma"
                     /coded_by="XM_054369333.1:547..4962"
                     /db_xref="GeneID:55561"
                     /db_xref="HGNC:HGNC:29829"
                     /db_xref="MIM:613991"
ORIGIN      
        1 mkmlhkweml kraetacfre erdvlvkgds rwvttlhyaf qdeeylylvm dyyaggdllt
       61 llsrfedrlp pelaqfylae mvlaihslhq lgyvhrdvkp dnvlldvngh irladfgscl
      121 rlntngmvds svavgtpdyi speilqamee gkghygpqcd wwslgvcaye llfgetpfya
      181 eslvetygki mnhedhlqfp pdvpdvpasa qdlirqllcr qeerlgrggl ddfrnhpffe
      241 gvdwerlass tapyipelrg pmdtsnfdvd ddtlnhpgtl pppshgafsg hhlpfvgfty
      301 tsgshspess seawaalerk lqcleqekve lsrkhqealh aptdhreleq lrkevqtlrd
      361 rlpemlrdka slsqtdgppa gspgqdsdlr qeldrlhrel aegraglqaq eqelcraqgq
      421 qeellqrlqe aqereaatas qtralssqle earaaqrele aqvsslsrqv tqlqgqweqr
      481 leessqakti htasetngmg ppeggpqeaq lrkevaalre qleqahshrp sgkeealcql
      541 qeenrrlsre qerleaelaq eqeskqrleg erretesnwe aqladilswv ndekvsrgyl
      601 qalatkmaee leslrnvgtq tlparpldhq wkarrlqkme asarlelqsa leaeirakqg
      661 lqerltqvqe aqlqaerrlq eaekqsqalq qelamlreel rargpvdtkp snslipflsf
      721 rssekdsakd pgisgeatrh ggepdlrpeg rrslrmgavf praptantas teglpakgwg
      781 mgpwealgng cpppqpgsht lrprsfpspt kclrctslml glgrqglgcd acgyfchttc
      841 apqappcpvp pdllrtalgv hpetgtgtay egflsvprps gvrrgwqrvf aalsdsrlll
      901 fdapdlrlsp psgallqvld lrdpqfsatp vlasdvihaq srdlprifrv ttsqlavppt
      961 tctvlllaes egererwlqv lgelqrllld arprprpvyt lkeaydnglp llphtlcaai
     1021 ldqdrlalgt eeglfvihlr sndifqvgec rrvqrltlsp sagllvvlcg rgpsvrlfal
     1081 aelenievag akipesrgcq vlaagsilqa rtpvlcvavk rqvlcyqlgp gpgpwqrrir
     1141 elqapatvqs lgllgdrlcv gaaggfalyp llneaaplal gaglvpeelp psrgglgeal
     1201 gavelslsef lllfttagiy vdgagrksrg hellwpaapm gwgyaapylt vfsensidvf
     1261 dvrraewvqt vplkkvrpln pegslflygt ekvrltylrn qlaekdefdi pdltdnsrrq
     1321 lfrtkskrrf ffrvseeqqk qqrremlkdp fvrsklispp tnfnhlvhvg pangrpgard
     1381 kspapeekgr vargsgpqrp hsfsealrrp asmgseglgg dadpmkrkpw tslssesvsc
     1441 pqgslspats lmqvserprs lplspeless p
//
LOCUS       XP_054225309            1139 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase MRCK gamma isoform X11 [Homo
            sapiens].
ACCESSION   XP_054225309
VERSION     XP_054225309.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369334.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1139
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1139
                     /product="serine/threonine-protein kinase MRCK gamma
                     isoform X11"
                     /calculated_mol_wt=126988
     Region          69..399
                     /region_name="STKc_DMPK_like"
                     /note="Catalytic domain of Myotonic Dystrophy protein
                     kinase (DMPK)-like Serine/Threonine Kinases; cd05597"
                     /db_xref="CDD:270748"
     Site            order(77..81,85,98,100,132,148..149,151,155,157,195,197,
                     199..200,202,212..213,216,231..236,268,274,277)
                     /site_type="active"
                     /db_xref="CDD:270748"
     Site            order(77..81,85,98,100,132,149..151,155,195,197,199..200,
                     202,212..213)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270748"
     Site            order(81,155,157,195,197,199,216,231..236,268,274,277)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270748"
     Site            order(212..222,225..236)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270748"
     Site            393..398
                     /site_type="other"
                     /note="hydrophobic motif (HM)"
                     /db_xref="CDD:270748"
     Region          <444..805
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          897..939
                     /region_name="C1_MRCKgamma"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in myotonic dystrophy kinase-related Cdc42-binding
                     kinase gamma (MRCK gamma) and similar proteins; cd20866"
                     /db_xref="CDD:410416"
     Site            order(902..908,916..920,923)
                     /site_type="other"
                     /note="putative DAG/PE binding site [chemical binding]"
                     /db_xref="CDD:410416"
     Region          956..1088
                     /region_name="PH_MRCK"
                     /note="MRCK (myotonic dystrophy-related Cdc42-binding
                     kinase) pleckstrin homology (PH) domain; cd01243"
                     /db_xref="CDD:269949"
     CDS             1..1139
                     /gene="CDC42BPG"
                     /gene_synonym="DMPK2; HSMDPKIN; KAPPA-200; MRCKG;
                     MRCKgamma"
                     /coded_by="XM_054369334.1:85..3504"
                     /db_xref="GeneID:55561"
                     /db_xref="HGNC:HGNC:29829"
                     /db_xref="MIM:613991"
ORIGIN      
        1 merrlraleq largeaggcp gldglldlll alhhelssgp lrrersvaqf lswaspfvsk
       61 vkelrlqrdd feilkvigrg afgevtvvrq rdtgqifamk mlhkwemlkr aetacfreer
      121 dvlvkgdsrw vttlhyafqd eeylylvmdy yaggdlltll srfedrlppe laqfylaemv
      181 laihslhqlg yvhrdvkpdn vlldvnghir ladfgsclrl ntngmvdssv avgtpdyisp
      241 eilqameegk ghygpqcdww slgvcayell fgetpfyaes lvetygkimn hedhlqfppd
      301 vpdvpasaqd lirqllcrqe erlgrggldd frnhpffegv dwerlassta pyipelrgpm
      361 dtsnfdvddd tlnhpgtlpp pshgafsghh lpfvgftyts gshspessse awaalerklq
      421 cleqekvels rkhqealhap tdhreleqlr kevqtlrdrl pemlrdkasl sqtdgppags
      481 pgqdsdlrqe ldrlhrelae graglqaqeq elcraqgqqe ellqrlqeaq ereaatasqt
      541 ralssqleea raaqreleaq vsslsrqvtq lqgqweqrle essqaktiht asetngmgpp
      601 eggpqeaqlr kevaalreql eqahshrpsg keealcqlqe enrrlsreqe rleaelaqeq
      661 eskqrleger retesnweaq ladilswvnd ekvsrgylqa latkmaeele slrnvgtqtl
      721 parpldhqwk arrlqkmeas arlelqsale aeirakqglq erltqvqeaq lqaerrlqea
      781 ekqsqalqqe lamlreelra rgpvdtkpsn slipflsfrs sekdsakdpg isgeatrhgg
      841 epdlrpegrr slrmgavfpr aptantaste glpakgwgmg pwealgngcp ppqpgshtlr
      901 prsfpsptkc lrctslmlgl grqglgcdac gyfchttcap qappcpvppd llrtalgvhp
      961 etgtgtayeg flsvprpsgv rrgwqrvfaa lsdsrlllfd apdlrlspps gallqvldlr
     1021 dpqfsatpvl asdvihaqsr dlprifrvtt sqlavppttc tvlllaeseg ererwlqvlg
     1081 elqrllldar prprpvytlk eaydnglpll phtlcaailg tagqvdcpis vslsgtadl
//
LOCUS       XP_054225310            1135 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase MRCK gamma isoform X12 [Homo
            sapiens].
ACCESSION   XP_054225310
VERSION     XP_054225310.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369335.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1135
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1135
                     /product="serine/threonine-protein kinase MRCK gamma
                     isoform X12"
                     /calculated_mol_wt=126938
     Region          69..399
                     /region_name="STKc_DMPK_like"
                     /note="Catalytic domain of Myotonic Dystrophy protein
                     kinase (DMPK)-like Serine/Threonine Kinases; cd05597"
                     /db_xref="CDD:270748"
     Site            order(77..81,85,98,100,132,148..149,151,155,157,195,197,
                     199..200,202,212..213,216,231..236,268,274,277)
                     /site_type="active"
                     /db_xref="CDD:270748"
     Site            order(77..81,85,98,100,132,149..151,155,195,197,199..200,
                     202,212..213)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270748"
     Site            order(81,155,157,195,197,199,216,231..236,268,274,277)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270748"
     Site            order(212..222,225..236)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270748"
     Site            393..398
                     /site_type="other"
                     /note="hydrophobic motif (HM)"
                     /db_xref="CDD:270748"
     Region          <444..805
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          897..939
                     /region_name="C1_MRCKgamma"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in myotonic dystrophy kinase-related Cdc42-binding
                     kinase gamma (MRCK gamma) and similar proteins; cd20866"
                     /db_xref="CDD:410416"
     Site            order(902..908,916..920,923)
                     /site_type="other"
                     /note="putative DAG/PE binding site [chemical binding]"
                     /db_xref="CDD:410416"
     Region          956..1088
                     /region_name="PH_MRCK"
                     /note="MRCK (myotonic dystrophy-related Cdc42-binding
                     kinase) pleckstrin homology (PH) domain; cd01243"
                     /db_xref="CDD:269949"
     CDS             1..1135
                     /gene="CDC42BPG"
                     /gene_synonym="DMPK2; HSMDPKIN; KAPPA-200; MRCKG;
                     MRCKgamma"
                     /coded_by="XM_054369335.1:85..3492"
                     /db_xref="GeneID:55561"
                     /db_xref="HGNC:HGNC:29829"
                     /db_xref="MIM:613991"
ORIGIN      
        1 merrlraleq largeaggcp gldglldlll alhhelssgp lrrersvaqf lswaspfvsk
       61 vkelrlqrdd feilkvigrg afgevtvvrq rdtgqifamk mlhkwemlkr aetacfreer
      121 dvlvkgdsrw vttlhyafqd eeylylvmdy yaggdlltll srfedrlppe laqfylaemv
      181 laihslhqlg yvhrdvkpdn vlldvnghir ladfgsclrl ntngmvdssv avgtpdyisp
      241 eilqameegk ghygpqcdww slgvcayell fgetpfyaes lvetygkimn hedhlqfppd
      301 vpdvpasaqd lirqllcrqe erlgrggldd frnhpffegv dwerlassta pyipelrgpm
      361 dtsnfdvddd tlnhpgtlpp pshgafsghh lpfvgftyts gshspessse awaalerklq
      421 cleqekvels rkhqealhap tdhreleqlr kevqtlrdrl pemlrdkasl sqtdgppags
      481 pgqdsdlrqe ldrlhrelae graglqaqeq elcraqgqqe ellqrlqeaq ereaatasqt
      541 ralssqleea raaqreleaq vsslsrqvtq lqgqweqrle essqaktiht asetngmgpp
      601 eggpqeaqlr kevaalreql eqahshrpsg keealcqlqe enrrlsreqe rleaelaqeq
      661 eskqrleger retesnweaq ladilswvnd ekvsrgylqa latkmaeele slrnvgtqtl
      721 parpldhqwk arrlqkmeas arlelqsale aeirakqglq erltqvqeaq lqaerrlqea
      781 ekqsqalqqe lamlreelra rgpvdtkpsn slipflsfrs sekdsakdpg isgeatrhgg
      841 epdlrpegrr slrmgavfpr aptantaste glpakgwgmg pwealgngcp ppqpgshtlr
      901 prsfpsptkc lrctslmlgl grqglgcdac gyfchttcap qappcpvppd llrtalgvhp
      961 etgtgtayeg flsvprpsgv rrgwqrvfaa lsdsrlllfd apdlrlspps gallqvldlr
     1021 dpqfsatpvl asdvihaqsr dlprifrvtt sqlavppttc tvlllaeseg ererwlqvlg
     1081 elqrllldar prprpvytlk eaydnglpll phtlcaaild kqaqqgrwta qspch
//
LOCUS       XP_054225311            1121 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase MRCK gamma isoform X13 [Homo
            sapiens].
ACCESSION   XP_054225311
VERSION     XP_054225311.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369336.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1121
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1121
                     /product="serine/threonine-protein kinase MRCK gamma
                     isoform X13"
                     /calculated_mol_wt=125152
     Region          69..399
                     /region_name="STKc_DMPK_like"
                     /note="Catalytic domain of Myotonic Dystrophy protein
                     kinase (DMPK)-like Serine/Threonine Kinases; cd05597"
                     /db_xref="CDD:270748"
     Site            order(77..81,85,98,100,132,148..149,151,155,157,195,197,
                     199..200,202,212..213,216,231..236,268,274,277)
                     /site_type="active"
                     /db_xref="CDD:270748"
     Site            order(77..81,85,98,100,132,149..151,155,195,197,199..200,
                     202,212..213)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270748"
     Site            order(81,155,157,195,197,199,216,231..236,268,274,277)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270748"
     Site            order(212..222,225..236)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270748"
     Site            393..398
                     /site_type="other"
                     /note="hydrophobic motif (HM)"
                     /db_xref="CDD:270748"
     Region          <444..805
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          879..921
                     /region_name="C1_MRCKgamma"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in myotonic dystrophy kinase-related Cdc42-binding
                     kinase gamma (MRCK gamma) and similar proteins; cd20866"
                     /db_xref="CDD:410416"
     Site            order(884..890,898..902,905)
                     /site_type="other"
                     /note="putative DAG/PE binding site [chemical binding]"
                     /db_xref="CDD:410416"
     Region          938..1070
                     /region_name="PH_MRCK"
                     /note="MRCK (myotonic dystrophy-related Cdc42-binding
                     kinase) pleckstrin homology (PH) domain; cd01243"
                     /db_xref="CDD:269949"
     CDS             1..1121
                     /gene="CDC42BPG"
                     /gene_synonym="DMPK2; HSMDPKIN; KAPPA-200; MRCKG;
                     MRCKgamma"
                     /coded_by="XM_054369336.1:85..3450"
                     /db_xref="GeneID:55561"
                     /db_xref="HGNC:HGNC:29829"
                     /db_xref="MIM:613991"
ORIGIN      
        1 merrlraleq largeaggcp gldglldlll alhhelssgp lrrersvaqf lswaspfvsk
       61 vkelrlqrdd feilkvigrg afgevtvvrq rdtgqifamk mlhkwemlkr aetacfreer
      121 dvlvkgdsrw vttlhyafqd eeylylvmdy yaggdlltll srfedrlppe laqfylaemv
      181 laihslhqlg yvhrdvkpdn vlldvnghir ladfgsclrl ntngmvdssv avgtpdyisp
      241 eilqameegk ghygpqcdww slgvcayell fgetpfyaes lvetygkimn hedhlqfppd
      301 vpdvpasaqd lirqllcrqe erlgrggldd frnhpffegv dwerlassta pyipelrgpm
      361 dtsnfdvddd tlnhpgtlpp pshgafsghh lpfvgftyts gshspessse awaalerklq
      421 cleqekvels rkhqealhap tdhreleqlr kevqtlrdrl pemlrdkasl sqtdgppags
      481 pgqdsdlrqe ldrlhrelae graglqaqeq elcraqgqqe ellqrlqeaq ereaatasqt
      541 ralssqleea raaqreleaq vsslsrqvtq lqgqweqrle essqaktiht asetngmgpp
      601 eggpqeaqlr kevaalreql eqahshrpsg keealcqlqe enrrlsreqe rleaelaqeq
      661 eskqrleger retesnweaq ladilswvnd ekvsrgylqa latkmaeele slrnvgtqtl
      721 parpldhqwk arrlqkmeas arlelqsale aeirakqglq erltqvqeaq lqaerrlqea
      781 ekqsqalqqe lamlreelra rgpvdtkpsn slipflsfrs sekdsakdpg isgeatrhgg
      841 epdlrpegrr slrmgavfpr aptantaste glpakpgsht lrprsfpspt kclrctslml
      901 glgrqglgcd acgyfchttc apqappcpvp pdllrtalgv hpetgtgtay egflsvprps
      961 gvrrgwqrvf aalsdsrlll fdapdlrlsp psgallqvld lrdpqfsatp vlasdvihaq
     1021 srdlprifrv ttsqlavppt tctvlllaes egererwlqv lgelqrllld arprprpvyt
     1081 lkeaydnglp llphtlcaai lgtagqvdcp isvslsgtad l
//
LOCUS       XP_054225312            1081 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase MRCK gamma isoform X14 [Homo
            sapiens].
ACCESSION   XP_054225312
VERSION     XP_054225312.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369337.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1081
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1081
                     /product="serine/threonine-protein kinase MRCK gamma
                     isoform X14"
                     /calculated_mol_wt=120559
     Region          69..399
                     /region_name="STKc_DMPK_like"
                     /note="Catalytic domain of Myotonic Dystrophy protein
                     kinase (DMPK)-like Serine/Threonine Kinases; cd05597"
                     /db_xref="CDD:270748"
     Site            order(77..81,85,98,100,132,148..149,151,155,157,195,197,
                     199..200,202,212..213,216,231..236,268,274,277)
                     /site_type="active"
                     /db_xref="CDD:270748"
     Site            order(77..81,85,98,100,132,149..151,155,195,197,199..200,
                     202,212..213)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270748"
     Site            order(81,155,157,195,197,199,216,231..236,268,274,277)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270748"
     Site            order(212..222,225..236)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270748"
     Site            393..398
                     /site_type="other"
                     /note="hydrophobic motif (HM)"
                     /db_xref="CDD:270748"
     Region          <444..805
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          897..939
                     /region_name="C1_MRCKgamma"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in myotonic dystrophy kinase-related Cdc42-binding
                     kinase gamma (MRCK gamma) and similar proteins; cd20866"
                     /db_xref="CDD:410416"
     Site            order(902..908,916..920,923)
                     /site_type="other"
                     /note="putative DAG/PE binding site [chemical binding]"
                     /db_xref="CDD:410416"
     Region          956..>1047
                     /region_name="PH-like"
                     /note="Pleckstrin homology-like domain; cl17171"
                     /db_xref="CDD:473070"
     CDS             1..1081
                     /gene="CDC42BPG"
                     /gene_synonym="DMPK2; HSMDPKIN; KAPPA-200; MRCKG;
                     MRCKgamma"
                     /coded_by="XM_054369337.1:85..3330"
                     /db_xref="GeneID:55561"
                     /db_xref="HGNC:HGNC:29829"
                     /db_xref="MIM:613991"
ORIGIN      
        1 merrlraleq largeaggcp gldglldlll alhhelssgp lrrersvaqf lswaspfvsk
       61 vkelrlqrdd feilkvigrg afgevtvvrq rdtgqifamk mlhkwemlkr aetacfreer
      121 dvlvkgdsrw vttlhyafqd eeylylvmdy yaggdlltll srfedrlppe laqfylaemv
      181 laihslhqlg yvhrdvkpdn vlldvnghir ladfgsclrl ntngmvdssv avgtpdyisp
      241 eilqameegk ghygpqcdww slgvcayell fgetpfyaes lvetygkimn hedhlqfppd
      301 vpdvpasaqd lirqllcrqe erlgrggldd frnhpffegv dwerlassta pyipelrgpm
      361 dtsnfdvddd tlnhpgtlpp pshgafsghh lpfvgftyts gshspessse awaalerklq
      421 cleqekvels rkhqealhap tdhreleqlr kevqtlrdrl pemlrdkasl sqtdgppags
      481 pgqdsdlrqe ldrlhrelae graglqaqeq elcraqgqqe ellqrlqeaq ereaatasqt
      541 ralssqleea raaqreleaq vsslsrqvtq lqgqweqrle essqaktiht asetngmgpp
      601 eggpqeaqlr kevaalreql eqahshrpsg keealcqlqe enrrlsreqe rleaelaqeq
      661 eskqrleger retesnweaq ladilswvnd ekvsrgylqa latkmaeele slrnvgtqtl
      721 parpldhqwk arrlqkmeas arlelqsale aeirakqglq erltqvqeaq lqaerrlqea
      781 ekqsqalqqe lamlreelra rgpvdtkpsn slipflsfrs sekdsakdpg isgeatrhgg
      841 epdlrpegrr slrmgavfpr aptantaste glpakgwgmg pwealgngcp ppqpgshtlr
      901 prsfpsptkc lrctslmlgl grqglgcdac gyfchttcap qappcpvppd llrtalgvhp
      961 etgtgtayeg flsvprpsgv rrgwqrvfaa lsdsrlllfd apdlrlspps gallqvldlr
     1021 dpqfsatpvl asdvihaqsr dlprifrtri dlrlaprrgs lssicaatts srwgsagacs
     1081 g
//
LOCUS       XP_054225314             471 aa            linear   PRI 05-AUG-2025
DEFINITION  FAD-dependent oxidoreductase domain-containing protein 1 isoform X2
            [Homo sapiens].
ACCESSION   XP_054225314
VERSION     XP_054225314.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369339.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..471
                     /product="FAD-dependent oxidoreductase domain-containing
                     protein 1 isoform X2"
                     /calculated_mol_wt=51845
     Region          63..458
                     /region_name="DadA"
                     /note="Glycine/D-amino acid oxidase (deaminating) [Amino
                     acid transport and metabolism]; COG0665"
                     /db_xref="CDD:440429"
     CDS             1..471
                     /gene="FOXRED1"
                     /gene_synonym="FP634; H17; MC1DN19"
                     /coded_by="XM_054369339.1:220..1635"
                     /db_xref="GeneID:55572"
                     /db_xref="HGNC:HGNC:26927"
                     /db_xref="MIM:613622"
ORIGIN      
        1 mahtgrtvgr lgegdwdgkv seikkkiksi lpgrscdllq dtshlppehs dvvivgggvl
       61 glsvaywlkk lesrrgairv lvverdhtys qastglsvgg icqqfslpen iqlslfsasf
      121 lrnineylav vdappldlrf npsgylllas ekdaaamesn vkvqrqegak vslmspdqlr
      181 nkfpwinteg valasygmed egwfdpwcll qglrrkvqsl gvlfcqgevt rfvsssqrml
      241 ttddkavvlk rihevhvkmd rsleyqpvec aivinaagaw saqiaalagv gegppgtlqg
      301 tklpveprkr yvyvwhcpqg pgletplvad tsgayfrreg lgsnylggrs pteeepdpan
      361 levdhdffqd kvwphlalrv pafetlkvqs awagyydynt fdqngvvgph plvvnmyfat
      421 gfsghglqqa pgigravaem vlkgrfqtid lspflftrfy lgekiqenni i
//
LOCUS       XP_054225315             316 aa            linear   PRI 05-AUG-2025
DEFINITION  FAD-dependent oxidoreductase domain-containing protein 1 isoform X3
            [Homo sapiens].
ACCESSION   XP_054225315
VERSION     XP_054225315.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369340.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 18% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..316
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..316
                     /product="FAD-dependent oxidoreductase domain-containing
                     protein 1 isoform X3"
                     /calculated_mol_wt=35090
     Region          <1..303
                     /region_name="DadA"
                     /note="Glycine/D-amino acid oxidase (deaminating) [Amino
                     acid transport and metabolism]; COG0665"
                     /db_xref="CDD:440429"
     CDS             1..316
                     /gene="FOXRED1"
                     /gene_synonym="FP634; H17; MC1DN19"
                     /coded_by="XM_054369340.1:909..1859"
                     /db_xref="GeneID:55572"
                     /db_xref="HGNC:HGNC:26927"
                     /db_xref="MIM:613622"
ORIGIN      
        1 mesnvkvqrq egakvslmsp dqlrnkfpwi ntegvalasy gmedegwfdp wcllqglrrk
       61 vqslgvlfcq gevtrfvsss qrmlttddka vvlkrihevh vkmdrsleyq pvecaivina
      121 agawsaqiaa lagvgegppg tlqgtklpve prkryvyvwh cpqgpgletp lvadtsgayf
      181 rreglgsnyl ggrspteqee pdpanlevdh dffqdkvwph lalrvpafet lkvqsawagy
      241 ydyntfdqng vvgphplvvn myfatgfsgh glqqapgigr avaemvlkgr fqtidlspfl
      301 ftrfylgeki qennii
//
LOCUS       XP_054225316             316 aa            linear   PRI 05-AUG-2025
DEFINITION  FAD-dependent oxidoreductase domain-containing protein 1 isoform X3
            [Homo sapiens].
ACCESSION   XP_054225316
VERSION     XP_054225316.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369341.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..316
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..316
                     /product="FAD-dependent oxidoreductase domain-containing
                     protein 1 isoform X3"
                     /calculated_mol_wt=35090
     Region          <1..303
                     /region_name="DadA"
                     /note="Glycine/D-amino acid oxidase (deaminating) [Amino
                     acid transport and metabolism]; COG0665"
                     /db_xref="CDD:440429"
     CDS             1..316
                     /gene="FOXRED1"
                     /gene_synonym="FP634; H17; MC1DN19"
                     /coded_by="XM_054369341.1:363..1313"
                     /db_xref="GeneID:55572"
                     /db_xref="HGNC:HGNC:26927"
                     /db_xref="MIM:613622"
ORIGIN      
        1 mesnvkvqrq egakvslmsp dqlrnkfpwi ntegvalasy gmedegwfdp wcllqglrrk
       61 vqslgvlfcq gevtrfvsss qrmlttddka vvlkrihevh vkmdrsleyq pvecaivina
      121 agawsaqiaa lagvgegppg tlqgtklpve prkryvyvwh cpqgpgletp lvadtsgayf
      181 rreglgsnyl ggrspteqee pdpanlevdh dffqdkvwph lalrvpafet lkvqsawagy
      241 ydyntfdqng vvgphplvvn myfatgfsgh glqqapgigr avaemvlkgr fqtidlspfl
      301 ftrfylgeki qennii
//
LOCUS       XP_054225317             275 aa            linear   PRI 05-AUG-2025
DEFINITION  FAD-dependent oxidoreductase domain-containing protein 1 isoform X4
            [Homo sapiens].
ACCESSION   XP_054225317
VERSION     XP_054225317.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369342.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..275
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..275
                     /product="FAD-dependent oxidoreductase domain-containing
                     protein 1 isoform X4"
                     /calculated_mol_wt=30528
     Region          <3..262
                     /region_name="DadA"
                     /note="Glycine/D-amino acid oxidase (deaminating) [Amino
                     acid transport and metabolism]; COG0665"
                     /db_xref="CDD:440429"
     CDS             1..275
                     /gene="FOXRED1"
                     /gene_synonym="FP634; H17; MC1DN19"
                     /coded_by="XM_054369342.1:391..1218"
                     /db_xref="GeneID:55572"
                     /db_xref="HGNC:HGNC:26927"
                     /db_xref="MIM:613622"
ORIGIN      
        1 medegwfdpw cllqglrrkv qslgvlfcqg evtrfvsssq rmlttddkav vlkrihevhv
       61 kmdrsleyqp vecaivinaa gawsaqiaal agvgegppgt lqgtklpvep rkryvyvwhc
      121 pqgpgletpl vadtsgayfr reglgsnylg grspteqeep dpanlevdhd ffqdkvwphl
      181 alrvpafetl kvqsawagyy dyntfdqngv vgphplvvnm yfatgfsghg lqqapgigra
      241 vaemvlkgrf qtidlspflf trfylgekiq ennii
//
LOCUS       XP_054225318             316 aa            linear   PRI 05-AUG-2025
DEFINITION  FAD-dependent oxidoreductase domain-containing protein 1 isoform X3
            [Homo sapiens].
ACCESSION   XP_054225318
VERSION     XP_054225318.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369343.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..316
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..316
                     /product="FAD-dependent oxidoreductase domain-containing
                     protein 1 isoform X3"
                     /calculated_mol_wt=35090
     Region          <1..303
                     /region_name="DadA"
                     /note="Glycine/D-amino acid oxidase (deaminating) [Amino
                     acid transport and metabolism]; COG0665"
                     /db_xref="CDD:440429"
     CDS             1..316
                     /gene="FOXRED1"
                     /gene_synonym="FP634; H17; MC1DN19"
                     /coded_by="XM_054369343.1:323..1273"
                     /db_xref="GeneID:55572"
                     /db_xref="HGNC:HGNC:26927"
                     /db_xref="MIM:613622"
ORIGIN      
        1 mesnvkvqrq egakvslmsp dqlrnkfpwi ntegvalasy gmedegwfdp wcllqglrrk
       61 vqslgvlfcq gevtrfvsss qrmlttddka vvlkrihevh vkmdrsleyq pvecaivina
      121 agawsaqiaa lagvgegppg tlqgtklpve prkryvyvwh cpqgpgletp lvadtsgayf
      181 rreglgsnyl ggrspteqee pdpanlevdh dffqdkvwph lalrvpafet lkvqsawagy
      241 ydyntfdqng vvgphplvvn myfatgfsgh glqqapgigr avaemvlkgr fqtidlspfl
      301 ftrfylgeki qennii
//
LOCUS       XP_054225319             865 aa            linear   PRI 05-AUG-2025
DEFINITION  phosphofurin acidic cluster sorting protein 1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225319
VERSION     XP_054225319.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369344.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..865
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..865
                     /product="phosphofurin acidic cluster sorting protein 1
                     isoform X1"
                     /calculated_mol_wt=95575
     Region          450..862
                     /region_name="Pacs-1"
                     /note="PACS-1 cytosolic sorting protein; pfam10254"
                     /db_xref="CDD:463027"
     CDS             1..865
                     /gene="PACS1"
                     /gene_synonym="MRD17; SHMS"
                     /coded_by="XM_054369344.1:33..2630"
                     /db_xref="GeneID:55690"
                     /db_xref="HGNC:HGNC:30032"
                     /db_xref="MIM:607492"
ORIGIN      
        1 mrtvagtpvm afprgclass rlfsltlkkl vmlkemdkdl nsvviavklq gskrilrsne
       61 ivlpasglve telqltfslq yphflkrdan klqimlqrrk ryknrtilgy ktlavglinm
      121 aevmqhpneg alvlglhsnv kdvsvpvaei kiyslssqpi dhegikskls drspdidnys
      181 eeeeesfsse qegsddplhg qdlfyededl rkvkktrrkl tstsaitrqp nikqkfvall
      241 krfkvsdevg fglehvsreq ireveedlde lydslemynp sdsgpemeet esilstpkpk
      301 lkpffegmsq sssqteigsl nskgslgkdt tspmelaale kikstwiknq ddsltetdtl
      361 eitdqdmfgd astslvvpek vktpmksskt dlqgsaspsk vegvhtprqk rstplkerql
      421 skplsertns sdserspdlg hstqiprkvv ydqlnqilvs daalpenvil vnttdwqgqy
      481 vaellqdqrk pvvctcstve vqavlsallt riqrycncns smprpvkvaa vggqsylssi
      541 lrffvkslan ktsdwlgymr fliiplgshp vakylgsvds kysssfldsg wrdlfsrsep
      601 pvseqldvag rvmqyvngaa tthqlpvaea mltcrhkfpd edsyqkfipf igvvkvglve
      661 dspstagdgd dspvvsltvp stsppsssgl srdatatpps spsmssalai vgspnspygd
      721 viglqvdywl ghpgerrreg dkrdassknt lksvfrsvqv srlphsgeaq lsgtmamtvv
      781 tkeknkkvpt iflskkprek evdsksqvie gisrlicsak qqqtmlrvsi dgvewsdikf
      841 fqlaaqwpth vkhfpvglfs gskat
//
LOCUS       XP_054225320             850 aa            linear   PRI 05-AUG-2025
DEFINITION  phosphofurin acidic cluster sorting protein 1 isoform X2 [Homo
            sapiens].
ACCESSION   XP_054225320
VERSION     XP_054225320.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369345.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..850
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..850
                     /product="phosphofurin acidic cluster sorting protein 1
                     isoform X2"
                     /calculated_mol_wt=94186
     Region          435..847
                     /region_name="Pacs-1"
                     /note="PACS-1 cytosolic sorting protein; pfam10254"
                     /db_xref="CDD:463027"
     CDS             1..850
                     /gene="PACS1"
                     /gene_synonym="MRD17; SHMS"
                     /coded_by="XM_054369345.1:1342..3894"
                     /db_xref="GeneID:55690"
                     /db_xref="HGNC:HGNC:30032"
                     /db_xref="MIM:607492"
ORIGIN      
        1 mehtfrlfsl tlkklvmlke mdkdlnsvvi avklqgskri lrsneivlpa sglvetelql
       61 tfslqyphfl krdanklqim lqrrkryknr tilgyktlav glinmaevmq hpnegalvlg
      121 lhsnvkdvsv pvaeikiysl ssqpidhegi ksklsdrspd idnyseeeee sfsseqegsd
      181 dplhgqdlfy ededlrkvkk trrkltstsa itrqpnikqk fvallkrfkv sdevgfgleh
      241 vsreqireve edldelydsl emynpsdsgp emeetesils tpkpklkpff egmsqsssqt
      301 eigslnskgs lgkdttspme laalekikst wiknqddslt etdtleitdq dmfgdastsl
      361 vvpekvktpm kssktdlqgs aspskvegvh tprqkrstpl kerqlskpls ertnssdser
      421 spdlghstqi prkvvydqln qilvsdaalp envilvnttd wqgqyvaell qdqrkpvvct
      481 cstvevqavl salltriqry cncnssmprp vkvaavggqs ylssilrffv kslanktsdw
      541 lgymrfliip lgshpvakyl gsvdskysss fldsgwrdlf srseppvseq ldvagrvmqy
      601 vngaatthql pvaeamltcr hkfpdedsyq kfipfigvvk vglvedspst agdgddspvv
      661 sltvpstspp sssglsrdat atppsspsms salaivgspn spygdviglq vdywlghpge
      721 rrregdkrda sskntlksvf rsvqvsrlph sgeaqlsgtm amtvvtkekn kkvptiflsk
      781 kprekevdsk sqviegisrl icsakqqqtm lrvsidgvew sdikffqlaa qwpthvkhfp
      841 vglfsgskat
//
LOCUS       XP_054225321             328 aa            linear   PRI 05-AUG-2025
DEFINITION  alpha-parvin isoform X1 [Homo sapiens].
ACCESSION   XP_054225321
VERSION     XP_054225321.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369346.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..328
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..328
                     /product="alpha-parvin isoform X1"
                     /calculated_mol_wt=37440
     Region          47..161
                     /region_name="CH_PARVA_rpt1"
                     /note="first calponin homology (CH) domain found in
                     alpha-parvin; cd21335"
                     /db_xref="CDD:409184"
     Site            order(53,57,108,110..111,114..115,117,129..137,142,
                     144..145,147..148,151..152,155)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409184"
     Region          200..328
                     /region_name="CH_PARVA_rpt2"
                     /note="second calponin homology (CH) domain found in
                     alpha-parvin; cd21337"
                     /db_xref="CDD:409186"
     Site            order(220,224,278,280..281,284..285,287,296..304,309,
                     311..312,314..315,318..319,322)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409186"
     CDS             1..328
                     /gene="PARVA"
                     /gene_synonym="CH-ILKBP; MXRA2"
                     /coded_by="XM_054369346.1:404..1390"
                     /db_xref="GeneID:55742"
                     /db_xref="HGNC:HGNC:14652"
                     /db_xref="MIM:608120"
ORIGIN      
        1 mvselqeegm nainlplspi pfeldpedtm leenevrtmv dpnsrsdpkl qelmkvlidw
       61 indvlvgeri ivkdlaedly dgqvlqklfe kleseklnva evtqseiaqk qklqtvleki
      121 netlklpprs ikwnvdsvha kslvailhll valsqyfrap irlpdhvsiq vvvvqkregi
      181 lqsrqiqeei tgntealsgr herdafdtlf dhapdklnvv kktlitfvnk hlnklnlevt
      241 eletqfadgv ylvllmglle gyfvplhsff ltpdsfeqkv lnvsfafelm qdgglekpkp
      301 rpedivncdl kstlrvlynl ftkyrnve
//
LOCUS       XP_054225322            1141 aa            linear   PRI 05-AUG-2025
DEFINITION  tetratricopeptide repeat protein 17 isoform X1 [Homo sapiens].
ACCESSION   XP_054225322
VERSION     XP_054225322.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369347.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1141
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1141
                     /product="tetratricopeptide repeat protein 17 isoform X1"
                     /calculated_mol_wt=129919
     Region          169..349
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          553..>679
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          564..590
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(566..567,570..571,573,597,602..603,606..607,
                     609..610,633,636..637,640..641,644)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          595..627
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          632..660
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1006..>1132
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          1016..1043
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(1018..1019,1022..1023,1025,1050,1055..1056,
                     1059..1060,1062..1063,1086,1089..1090,1093..1094,1097)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          1048..1080
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          1085..1113
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..1141
                     /gene="TTC17"
                     /coded_by="XM_054369347.1:107..3532"
                     /db_xref="GeneID:55761"
                     /db_xref="HGNC:HGNC:25596"
                     /db_xref="MIM:619388"
ORIGIN      
        1 mnlkhphdlv ilmrqeatvn ylkelekqlv aqkihieene drdtgleqrh nkedpdcika
       61 kvplgdldly dgtyitlesk dispedyidt espvppdpeq pdctkilelp ysihafqhlr
      121 gvqervnlsa pllpkedpif tylskrlgrs iddighlihe glqkntsswv lynmasfywr
      181 iknepyqvve camralhfss rhnkdialvn lanvlhrahf sadaavvvha alddsdffts
      241 yytlgniyam lgeynhsvlc ydhalqarpg feqaikrkha vlcqqkleqk leaqhrslqr
      301 tlnelkeyqk qhdhylrqqe ilekhkliqe eqilrniihe tqmakeaqlg nhqicrlvnq
      361 qhslhcqwdq pvryhrgdif envdyvqfge dsstssmmsv nfdvqsnqsd indsvksspv
      421 ahsilwiwgr dsdayrdkqh ilwpkradct esyprvpvgg elptyflppe nkglrihels
      481 sddysteeea qtpdcsitdf rkshtlsylv kelevrmdlk akmpddhark illsrinnyt
      541 ipeeeigsfl fhainkpnap iwlilneagl ywravgnstf aiaclqraln laplqyqdvp
      601 lvnlanllih yglhldatkl llqalainss epltflslgn aylalknisg aleafrqalk
      661 lttkcpecen slklircmqf ypflynitss vcsgnchekt ldnshdkqky fdnsqsldaa
      721 eeepsergte edpvfsvens grdsdalrle stvveesngs demensdetk mseeilalvd
      781 efqqawpleg fggalemkgr rldlqgirvl kkgpqdgvar sscygdcrse ddeatewitf
      841 qvkrvkkpkg dhkktpgkkv etgqienghr yqanleitgp kvaspgpqgk krdyqrlgwp
      901 spdeclklrw veltaivstw lavssknidi tehidfatpi qqpameplcn gnlptsmhtl
      961 dhlhgvsnra slhytgesql tevlqnlgkd qypqqsleqi gtriakvlek nqtswvlssm
     1021 aalywrvkgq gkkaidclrq alhyaphqmk dvplislani lhnaklwnda vivatmavei
     1081 aphfavnhft lgnvyvamee fekalvwyes tlklqpefvp aknriqtiqc hlmlkkgrrs
     1141 p
//
LOCUS       XP_054225323            1077 aa            linear   PRI 05-AUG-2025
DEFINITION  tetratricopeptide repeat protein 17 isoform X2 [Homo sapiens].
ACCESSION   XP_054225323
VERSION     XP_054225323.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369348.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1077
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1077
                     /product="tetratricopeptide repeat protein 17 isoform X2"
                     /calculated_mol_wt=122218
     Region          226..406
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          610..>736
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          621..647
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(623..624,627..628,630,654,659..660,663..664,
                     666..667,690,693..694,697..698,701)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          652..684
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          689..717
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..1077
                     /gene="TTC17"
                     /coded_by="XM_054369348.1:36..3269"
                     /db_xref="GeneID:55761"
                     /db_xref="HGNC:HGNC:25596"
                     /db_xref="MIM:619388"
ORIGIN      
        1 maaavgvrgr yelppcsgpg wllslsalls vaargafatt hwvvtedgki qqqvdspmnl
       61 khphdlvilm rqeatvnylk elekqlvaqk ihieenedrd tgleqrhnke dpdcikakvp
      121 lgdldlydgt yitleskdis pedyidtesp vppdpeqpdc tkilelpysi hafqhlrgvq
      181 ervnlsapll pkedpiftyl skrlgrsidd ighliheglq kntsswvlyn masfywrikn
      241 epyqvvecam ralhfssrhn kdialvnlan vlhrahfsad aavvvhaald dsdfftsyyt
      301 lgniyamlge ynhsvlcydh alqarpgfeq aikrkhavlc qqkleqklea qhrslqrtln
      361 elkeyqkqhd hylrqqeile khkliqeeqi lrniihetqm akeaqlgnhq icrlvnqqhs
      421 lhcqwdqpvr yhrgdifenv dyvqfgedss tssmmsvnfd vqsnqsdind svksspvahs
      481 ilwiwgrdsd ayrdkqhilw pkradctesy prvpvggelp tyflppenkg lrihelssdd
      541 ysteeeaqtp dcsitdfrks htlsylvkel evrmdlkakm pddharkill srinnytipe
      601 eeigsflfha inkpnapiwl ilneaglywr avgnstfaia clqralnlap lqyqdvplvn
      661 lanllihygl hldatklllq alainssepl tflslgnayl alknisgale afrqalkltt
      721 kcpecenslk lircmqfypf lynitssvcs gnchektldn shdkqkyfdn sqsldaaeee
      781 psergteedp vfsvensgrd sdalrlestv veesngsdem ensdetkmse eilalvdefq
      841 qawplegfgg alemkgrrld lqgirvlkkg pqdgvarssc ygdcrsedde atewitfqvk
      901 rvkkpkgdhk ktpgkkvetg qienghryqa nleitgpkva spgpqgkkrd yqrlgwpspd
      961 eclklrwvel taivstwlav sskniditeh idfatpiqqp ameplcngnl ptsmhtldhl
     1021 hgvsnraslh ytgesqltev lqnlgkdqyp qqsleqigtr iakvlekqeq wnqkttk
//
LOCUS       XP_054225324            1020 aa            linear   PRI 05-AUG-2025
DEFINITION  tetratricopeptide repeat protein 17 isoform X3 [Homo sapiens].
ACCESSION   XP_054225324
VERSION     XP_054225324.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369349.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1020
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1020
                     /product="tetratricopeptide repeat protein 17 isoform X3"
                     /calculated_mol_wt=115779
     Region          226..406
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          610..>736
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          621..647
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(623..624,627..628,630,654,659..660,663..664,
                     666..667,690,693..694,697..698,701)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          652..684
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          689..717
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..1020
                     /gene="TTC17"
                     /coded_by="XM_054369349.1:36..3098"
                     /db_xref="GeneID:55761"
                     /db_xref="HGNC:HGNC:25596"
                     /db_xref="MIM:619388"
ORIGIN      
        1 maaavgvrgr yelppcsgpg wllslsalls vaargafatt hwvvtedgki qqqvdspmnl
       61 khphdlvilm rqeatvnylk elekqlvaqk ihieenedrd tgleqrhnke dpdcikakvp
      121 lgdldlydgt yitleskdis pedyidtesp vppdpeqpdc tkilelpysi hafqhlrgvq
      181 ervnlsapll pkedpiftyl skrlgrsidd ighliheglq kntsswvlyn masfywrikn
      241 epyqvvecam ralhfssrhn kdialvnlan vlhrahfsad aavvvhaald dsdfftsyyt
      301 lgniyamlge ynhsvlcydh alqarpgfeq aikrkhavlc qqkleqklea qhrslqrtln
      361 elkeyqkqhd hylrqqeile khkliqeeqi lrniihetqm akeaqlgnhq icrlvnqqhs
      421 lhcqwdqpvr yhrgdifenv dyvqfgedss tssmmsvnfd vqsnqsdind svksspvahs
      481 ilwiwgrdsd ayrdkqhilw pkradctesy prvpvggelp tyflppenkg lrihelssdd
      541 ysteeeaqtp dcsitdfrks htlsylvkel evrmdlkakm pddharkill srinnytipe
      601 eeigsflfha inkpnapiwl ilneaglywr avgnstfaia clqralnlap lqyqdvplvn
      661 lanllihygl hldatklllq alainssepl tflslgnayl alknisgale afrqalkltt
      721 kcpecenslk lircmqfypf lynitssvcs gtvveesngs demensdetk mseeilalvd
      781 efqqawpleg fggalemkgr rldlqgirvl kkgpqdgvar sscygdcrse ddeatewitf
      841 qvkrvkkpkg dhkktpgkkv etgqienghr yqanleitgp kvaspgpqgk krdyqrlgwp
      901 spdeclklrw veltaivstw lavssknidi tehidfatpi qqpameplcn gnlptsmhtl
      961 dhlhgvsnra slhytgesql tevlqnlgkd qypqqsleqi gtriakvlek qeqwnqkttk
//
LOCUS       XP_054225325             899 aa            linear   PRI 05-AUG-2025
DEFINITION  tetratricopeptide repeat protein 17 isoform X4 [Homo sapiens].
ACCESSION   XP_054225325
VERSION     XP_054225325.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369350.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..899
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..899
                     /product="tetratricopeptide repeat protein 17 isoform X4"
                     /calculated_mol_wt=102042
     Region          226..406
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          610..>736
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          621..647
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(623..624,627..628,630,654,659..660,663..664,
                     666..667,690,693..694,697..698,701)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          652..684
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          689..717
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..899
                     /gene="TTC17"
                     /coded_by="XM_054369350.1:36..2735"
                     /db_xref="GeneID:55761"
                     /db_xref="HGNC:HGNC:25596"
                     /db_xref="MIM:619388"
ORIGIN      
        1 maaavgvrgr yelppcsgpg wllslsalls vaargafatt hwvvtedgki qqqvdspmnl
       61 khphdlvilm rqeatvnylk elekqlvaqk ihieenedrd tgleqrhnke dpdcikakvp
      121 lgdldlydgt yitleskdis pedyidtesp vppdpeqpdc tkilelpysi hafqhlrgvq
      181 ervnlsapll pkedpiftyl skrlgrsidd ighliheglq kntsswvlyn masfywrikn
      241 epyqvvecam ralhfssrhn kdialvnlan vlhrahfsad aavvvhaald dsdfftsyyt
      301 lgniyamlge ynhsvlcydh alqarpgfeq aikrkhavlc qqkleqklea qhrslqrtln
      361 elkeyqkqhd hylrqqeile khkliqeeqi lrniihetqm akeaqlgnhq icrlvnqqhs
      421 lhcqwdqpvr yhrgdifenv dyvqfgedss tssmmsvnfd vqsnqsdind svksspvahs
      481 ilwiwgrdsd ayrdkqhilw pkradctesy prvpvggelp tyflppenkg lrihelssdd
      541 ysteeeaqtp dcsitdfrks htlsylvkel evrmdlkakm pddharkill srinnytipe
      601 eeigsflfha inkpnapiwl ilneaglywr avgnstfaia clqralnlap lqyqdvplvn
      661 lanllihygl hldatklllq alainssepl tflslgnayl alknisgale afrqalkltt
      721 kcpecenslk lircmqfypf lynitssvcs gtvveesngs demensdetk mseeilalvd
      781 efqqawpleg fggalemkgr rldlqgirvl kkgpqdgvar sscygdcrse ddeatewitf
      841 qvkrvkkpkg dhkktpgkkv etgqienghr yqanleitgp kvaspgpqgl ldwktrkvp
//
LOCUS       XP_054225326             215 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium channel regulatory subunit beta-3 isoform X1 [Homo sapiens].
ACCESSION   XP_054225326
VERSION     XP_054225326.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369351.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..215
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..215
                     /product="sodium channel regulatory subunit beta-3 isoform
                     X1"
                     /calculated_mol_wt=24571
     Region          28..140
                     /region_name="V-set"
                     /note="Immunoglobulin V-set domain; pfam07686"
                     /db_xref="CDD:462230"
     CDS             1..215
                     /gene="SCN3B"
                     /gene_synonym="ATFB16; BRGDA7; HSA243396; SCNB3"
                     /coded_by="XM_054369351.1:425..1072"
                     /db_xref="GeneID:55800"
                     /db_xref="HGNC:HGNC:20665"
                     /db_xref="MIM:608214"
ORIGIN      
        1 mpafnrlfpl aslvliywvs vcfpvcvevp seteavqgnp mklrciscmk reeveattvv
       61 ewfyrpeggk dfliyeyrng hqevespfqg rlqwngskdl qdvsitvlnv tlndsglytc
      121 nvsrefefea hrpfvkttrl iplrvteeag edftsvvsei mmyillvflt lwlliemiyc
      181 yrkvskaeea aqenasdyla ipsenkensa vpvee
//
LOCUS       XP_054225327             579 aa            linear   PRI 05-AUG-2025
DEFINITION  vacuolar protein sorting-associated protein 11 homolog isoform X1
            [Homo sapiens].
ACCESSION   XP_054225327
VERSION     XP_054225327.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369352.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..579
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..579
                     /product="vacuolar protein sorting-associated protein 11
                     homolog isoform X1"
                     /calculated_mol_wt=67317
     Region          55..174
                     /region_name="Clathrin"
                     /note="Region in Clathrin and VPS; pfam00637"
                     /db_xref="CDD:459884"
     Region          458..501
                     /region_name="RING-H2_Vps11"
                     /note="RING finger, H2 subclass, found in vacuolar protein
                     sorting-associated protein 11 homolog (Vps11) and similar
                     proteins; cd16688"
                     /db_xref="CDD:438349"
     Region          502..545
                     /region_name="VPS11_C"
                     /note="Vacuolar protein sorting protein 11 C terminal;
                     pfam12451"
                     /db_xref="CDD:463590"
     CDS             1..579
                     /gene="VPS11"
                     /gene_synonym="DYT32; END1; HLD12; hVPS11; PEP5; RNF108"
                     /coded_by="XM_054369352.1:432..2171"
                     /db_xref="GeneID:55823"
                     /db_xref="HGNC:HGNC:14583"
                     /db_xref="MIM:608549"
ORIGIN      
        1 mlfkknlfem ainlaksqhl dsdglaqifm qygdhlyskg nhdgavqqyi rtigklepsy
       61 virkfldaqr ihnltaylqt lhrqslanad httlllncyt klkdssklee fikkksesev
      121 hfdvetaikv lrqagyysha lylaenhahh ewylkiqled iknyqealry igklpfeqae
      181 snmkrygkil mhhipeqttq llkglctdyr pslegrsdre apgcransee fipifannpr
      241 elkaflehms evqpdspqgi ydtllelrlq nwahekdpqv keklhaeais llksgrfcdv
      301 fdkalvlcqm hdfqdgvlyl yeqgklfqqi mhyhmqheqy rqvisvcerh geqdpslweq
      361 alsyfarkee dckeyvaavl khienknlmp pllvvqtlah nstatlsvir dylvqklqkq
      421 sqqiaqdelr vrryreettr irqeiqelka spkifqktkc sicnsalelp svhflcghsf
      481 hqhcfesyse sdadcptclp enrkvmdmir aqeqkrdlhd qfqhqlrcsn dsfsviadyf
      541 grgvfnkltl ltdpptarlt ssleaglqrd llmhsrrgt
//
LOCUS       XP_054225328             417 aa            linear   PRI 05-AUG-2025
DEFINITION  solute carrier family 22 member 11 isoform X1 [Homo sapiens].
ACCESSION   XP_054225328
VERSION     XP_054225328.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369353.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..417
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..417
                     /product="solute carrier family 22 member 11 isoform X1"
                     /calculated_mol_wt=45030
     Region          33..378
                     /region_name="MFS"
                     /note="Major Facilitator Superfamily; cl28910"
                     /db_xref="CDD:475125"
     Site            order(74..75,77..79,82,98,101..102,105,220,223..224,
                     227..229,232,252,256,307..308,312,316,332,335..336,
                     339..340,343)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:349949"
     CDS             1..417
                     /gene="SLC22A11"
                     /gene_synonym="hOAT4; OAT4"
                     /coded_by="XM_054369353.1:355..1608"
                     /db_xref="GeneID:55867"
                     /db_xref="HGNC:HGNC:18120"
                     /db_xref="MIM:607097"
ORIGIN      
        1 mprppagakl trsrvwtags mtaassppps wprfgrkpml swcclqlava gtstifaptf
       61 viycglrfva afgmagifls sltlmvewtt tsrravtmtv vgcafsagqa algglafalr
      121 dwrtlqlaas vpffaislis wwlpesarwl iikgkpdqal qelrkvarin ghkeaknlti
      181 evlmssvkee vasakeprsv ldlfcvpvlr wrscamlvvn fsllisyygl vfdlqslgrd
      241 ifllqalfga vdflgratta lllsflgrrt iqagsqamag lailanmlvp qdlqtlrvvf
      301 avlgkgcfgi sltcltiyka elfptpvrmt adgilhtvgr lgammgplil msrqalpllp
      361 pllygvisia sslvvlfflp etqglplpdt iqdlesqkst aaqgnrqeav tvestsl
//
LOCUS       XP_054225329             342 aa            linear   PRI 05-AUG-2025
DEFINITION  cytotoxic and regulatory T-cell molecule isoform X1 [Homo sapiens].
ACCESSION   XP_054225329
VERSION     XP_054225329.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369354.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..342
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..342
                     /product="cytotoxic and regulatory T-cell molecule isoform
                     X1"
                     /calculated_mol_wt=38843
     Region          21..>65
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          34..38
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409382"
     Region          47..51
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409382"
     Region          70..156
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          86..90
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409418"
     Region          100..104
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409418"
     Region          130..134
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409418"
     Region          142..147
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409418"
     Region          158..161
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409418"
     CDS             1..342
                     /gene="CRTAM"
                     /gene_synonym="CD355"
                     /coded_by="XM_054369354.1:48..1076"
                     /db_xref="GeneID:56253"
                     /db_xref="HGNC:HGNC:24313"
                     /db_xref="MIM:612597"
ORIGIN      
        1 mwwrvlslla wfplqeaslt nhtetitvee gqtltlkcvt slrknsslqw ltpsgftifl
       61 neypatpfkp ileasvirkq ngeehvvlmc stmrskpppq itwllgnsme vsggtlhefe
      121 tdgkkcntts tliihtygkn stvdciirhr glqgrklvap frfedlvtde etasdalern
      181 slssqdpqqp tstvsvteds stseidkeek eqttqdpdlt teanpqylgl arkksgilll
      241 tlvsflifil fiivqlfimk lrkahviwkr enevsehtle syrsrsnnee tsseekngqs
      301 shpmrcmnyi tklyseaktk rkenvqhskl eekhiqvpes iv
//
LOCUS       XP_054225330             191 aa            linear   PRI 05-AUG-2025
DEFINITION  matrix metalloproteinase-26 isoform X1 [Homo sapiens].
ACCESSION   XP_054225330
VERSION     XP_054225330.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369355.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 27% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..191
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..191
                     /product="matrix metalloproteinase-26 isoform X1"
                     /calculated_mol_wt=21393
     Region          28..183
                     /region_name="Peptidase_M10"
                     /note="Matrixin; pfam00413"
                     /db_xref="CDD:425668"
     CDS             1..191
                     /gene="MMP26"
                     /coded_by="XM_054369355.1:582..1157"
                     /db_xref="GeneID:56547"
                     /db_xref="HGNC:HGNC:14249"
                     /db_xref="MIM:605470"
ORIGIN      
        1 mqmhallhqp hcgvpdgsdt sispgrckwn khtltyriin yphdmkpsav kdsiynavsi
       61 wsnvtplifq qvqngdadik vsfwqwahed gwpfdgpggi lghaflpnsg npgvvhfdkn
      121 ehwsasdtgy nlflvathei ghslglqhsg nqssimypty wyhdprtfql saddiqriqh
      181 lygekcssdi p
//
LOCUS       XP_054225331             494 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protease serine 4 isoform X1 [Homo sapiens].
ACCESSION   XP_054225331
VERSION     XP_054225331.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369356.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..494
                     /product="transmembrane protease serine 4 isoform X1"
                     /calculated_mol_wt=54459
     Region          58..92
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(62,71,82..83)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(75,78,82,88..89)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            85..89
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          108..197
                     /region_name="SRCR_2"
                     /note="Scavenger receptor cysteine-rich domain; cl02509"
                     /db_xref="CDD:470597"
     Region          204..429
                     /region_name="Tryp_SPc"
                     /note="Trypsin-like serine protease; smart00020"
                     /db_xref="CDD:214473"
     Site            205
                     /site_type="active"
                     /note="cleavage site [active]"
                     /db_xref="CDD:238113"
     Site            order(245,290,387)
                     /site_type="active"
                     /db_xref="CDD:238113"
     Site            order(381,405,407)
                     /site_type="other"
                     /note="substrate binding sites [chemical binding]"
                     /db_xref="CDD:238113"
     CDS             1..494
                     /gene="TMPRSS4"
                     /gene_synonym="CAP2; CAPH2; MT-SP2; TMPRSS3"
                     /coded_by="XM_054369356.1:226..1710"
                     /db_xref="GeneID:56649"
                     /db_xref="HGNC:HGNC:11878"
                     /db_xref="MIM:606565"
ORIGIN      
        1 mlqdpdsdqp lnsldvkplr kpripmetfr kvgipiiial lslasiiivv vlikvildky
       61 yflcgqplhf iprkqlcdge ldcplgedee hcvksfpegp avavrlskdr stlqvldsat
      121 gnwfsacfdn ftealaetac rqmgysskpt fraveigpdq dldvveiten sqelrmrnss
      181 gpclsgslvs lhclacgksl ktprvvggee asvdswpwqv siqydkqhvc ggsildphwv
      241 ltaahcfrkh tdvfnwkvra gsdklgsfps lavakiiiie fnpmypkdnd ialmklqfpl
      301 tfsgtvrpic lpffdeeltp atplwiigwg ftkqnggkms dillqasvqv idstrcnadd
      361 ayqgevtekm mcagipeggv dtcqgdsggp lmyqsdqwhv vgivswgygc ggpstpgvyt
      421 kvsaylnwiy nvwkdrtiqr scnspgtglv iqqpavplme lrsarhthrl itcvcflsfp
      481 alqplsplcp fpwd
//
LOCUS       XP_054225332             492 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protease serine 4 isoform X2 [Homo sapiens].
ACCESSION   XP_054225332
VERSION     XP_054225332.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369357.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..492
                     /product="transmembrane protease serine 4 isoform X2"
                     /calculated_mol_wt=54218
     Region          56..90
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(60,69,80..81)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(73,76,80,86..87)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            83..87
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          106..195
                     /region_name="SRCR_2"
                     /note="Scavenger receptor cysteine-rich domain; cl02509"
                     /db_xref="CDD:470597"
     Region          202..427
                     /region_name="Tryp_SPc"
                     /note="Trypsin-like serine protease; smart00020"
                     /db_xref="CDD:214473"
     Site            203
                     /site_type="active"
                     /note="cleavage site [active]"
                     /db_xref="CDD:238113"
     Site            order(243,288,385)
                     /site_type="active"
                     /db_xref="CDD:238113"
     Site            order(379,403,405)
                     /site_type="other"
                     /note="substrate binding sites [chemical binding]"
                     /db_xref="CDD:238113"
     CDS             1..492
                     /gene="TMPRSS4"
                     /gene_synonym="CAP2; CAPH2; MT-SP2; TMPRSS3"
                     /coded_by="XM_054369357.1:226..1704"
                     /db_xref="GeneID:56649"
                     /db_xref="HGNC:HGNC:11878"
                     /db_xref="MIM:606565"
ORIGIN      
        1 mdpdsdqpln sldvkplrkp ripmetfrkv gipiiialls lasiiivvvl ikvildkyyf
       61 lcgqplhfip rkqlcdgeld cplgedeehc vksfpegpav avrlskdrst lqvldsatgn
      121 wfsacfdnft ealaetacrq mgysskptfr aveigpdqdl dvveitensq elrmrnssgp
      181 clsgslvslh clacgkslkt prvvggeeas vdswpwqvsi qydkqhvcgg sildphwvlt
      241 aahcfrkhtd vfnwkvrags dklgsfpsla vakiiiiefn pmypkdndia lmklqfpltf
      301 sgtvrpiclp ffdeeltpat plwiigwgft kqnggkmsdi llqasvqvid strcnadday
      361 qgevtekmmc agipeggvdt cqgdsggplm yqsdqwhvvg ivswgygcgg pstpgvytkv
      421 saylnwiynv wkdrtiqrsc nspgtglviq qpavplmelr sarhthrlit cvcflsfpal
      481 qplsplcpfp wd
//
LOCUS       XP_054225333             489 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protease serine 4 isoform X3 [Homo sapiens].
ACCESSION   XP_054225333
VERSION     XP_054225333.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369358.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..489
                     /product="transmembrane protease serine 4 isoform X3"
                     /calculated_mol_wt=53898
     Region          58..92
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(62,71,82..83)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(75,78,82,88..89)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            85..89
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          108..192
                     /region_name="SRCR_2"
                     /note="Scavenger receptor cysteine-rich domain; cl02509"
                     /db_xref="CDD:470597"
     Region          199..424
                     /region_name="Tryp_SPc"
                     /note="Trypsin-like serine protease; smart00020"
                     /db_xref="CDD:214473"
     Site            200
                     /site_type="active"
                     /note="cleavage site [active]"
                     /db_xref="CDD:238113"
     Site            order(240,285,382)
                     /site_type="active"
                     /db_xref="CDD:238113"
     Site            order(376,400,402)
                     /site_type="other"
                     /note="substrate binding sites [chemical binding]"
                     /db_xref="CDD:238113"
     CDS             1..489
                     /gene="TMPRSS4"
                     /gene_synonym="CAP2; CAPH2; MT-SP2; TMPRSS3"
                     /coded_by="XM_054369358.1:226..1695"
                     /db_xref="GeneID:56649"
                     /db_xref="HGNC:HGNC:11878"
                     /db_xref="MIM:606565"
ORIGIN      
        1 mlqdpdsdqp lnsldvkplr kpripmetfr kvgipiiial lslasiiivv vlikvildky
       61 yflcgqplhf iprkqlcdge ldcplgedee hcvksfpegp avavrlskdr stlqvldsat
      121 gnwfsacfdn ftealaetac rqmgysrave igpdqdldvv eitensqelr mrnssgpcls
      181 gslvslhcla cgkslktprv vggeeasvds wpwqvsiqyd kqhvcggsil dphwvltaah
      241 cfrkhtdvfn wkvragsdkl gsfpslavak iiiiefnpmy pkdndialmk lqfpltfsgt
      301 vrpiclpffd eeltpatplw iigwgftkqn ggkmsdillq asvqvidstr cnaddayqge
      361 vtekmmcagi peggvdtcqg dsggplmyqs dqwhvvgivs wgygcggpst pgvytkvsay
      421 lnwiynvwkd rtiqrscnsp gtglviqqpa vplmelrsar hthrlitcvc flsfpalqpl
      481 splcpfpwd
//
LOCUS       XP_054225334             487 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protease serine 4 isoform X4 [Homo sapiens].
ACCESSION   XP_054225334
VERSION     XP_054225334.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369359.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..487
                     /product="transmembrane protease serine 4 isoform X4"
                     /calculated_mol_wt=53657
     Region          56..90
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(60,69,80..81)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(73,76,80,86..87)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            83..87
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          106..190
                     /region_name="SRCR_2"
                     /note="Scavenger receptor cysteine-rich domain; cl02509"
                     /db_xref="CDD:470597"
     Region          197..422
                     /region_name="Tryp_SPc"
                     /note="Trypsin-like serine protease; smart00020"
                     /db_xref="CDD:214473"
     Site            198
                     /site_type="active"
                     /note="cleavage site [active]"
                     /db_xref="CDD:238113"
     Site            order(238,283,380)
                     /site_type="active"
                     /db_xref="CDD:238113"
     Site            order(374,398,400)
                     /site_type="other"
                     /note="substrate binding sites [chemical binding]"
                     /db_xref="CDD:238113"
     CDS             1..487
                     /gene="TMPRSS4"
                     /gene_synonym="CAP2; CAPH2; MT-SP2; TMPRSS3"
                     /coded_by="XM_054369359.1:226..1689"
                     /db_xref="GeneID:56649"
                     /db_xref="HGNC:HGNC:11878"
                     /db_xref="MIM:606565"
ORIGIN      
        1 mdpdsdqpln sldvkplrkp ripmetfrkv gipiiialls lasiiivvvl ikvildkyyf
       61 lcgqplhfip rkqlcdgeld cplgedeehc vksfpegpav avrlskdrst lqvldsatgn
      121 wfsacfdnft ealaetacrq mgysraveig pdqdldvvei tensqelrmr nssgpclsgs
      181 lvslhclacg kslktprvvg geeasvdswp wqvsiqydkq hvcggsildp hwvltaahcf
      241 rkhtdvfnwk vragsdklgs fpslavakii iiefnpmypk dndialmklq fpltfsgtvr
      301 piclpffdee ltpatplwii gwgftkqngg kmsdillqas vqvidstrcn addayqgevt
      361 ekmmcagipe ggvdtcqgds ggplmyqsdq whvvgivswg ygcggpstpg vytkvsayln
      421 wiynvwkdrt iqrscnspgt glviqqpavp lmelrsarht hrlitcvcfl sfpalqplsp
      481 lcpfpwd
//
LOCUS       XP_054225335             456 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protease serine 4 isoform X5 [Homo sapiens].
ACCESSION   XP_054225335
VERSION     XP_054225335.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369360.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..456
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..456
                     /product="transmembrane protease serine 4 isoform X5"
                     /calculated_mol_wt=50240
     Region          20..54
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(24,33,44..45)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(37,40,44,50..51)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            47..51
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          70..159
                     /region_name="SRCR_2"
                     /note="Scavenger receptor cysteine-rich domain; cl02509"
                     /db_xref="CDD:470597"
     Region          166..391
                     /region_name="Tryp_SPc"
                     /note="Trypsin-like serine protease; smart00020"
                     /db_xref="CDD:214473"
     Site            167
                     /site_type="active"
                     /note="cleavage site [active]"
                     /db_xref="CDD:238113"
     Site            order(207,252,349)
                     /site_type="active"
                     /db_xref="CDD:238113"
     Site            order(343,367,369)
                     /site_type="other"
                     /note="substrate binding sites [chemical binding]"
                     /db_xref="CDD:238113"
     CDS             1..456
                     /gene="TMPRSS4"
                     /gene_synonym="CAP2; CAPH2; MT-SP2; TMPRSS3"
                     /coded_by="XM_054369360.1:226..1596"
                     /db_xref="GeneID:56649"
                     /db_xref="HGNC:HGNC:11878"
                     /db_xref="MIM:606565"
ORIGIN      
        1 mlqdpdsdqp lnslvkvild kyyflcgqpl hfiprkqlcd geldcplged eehcvksfpe
       61 gpavavrlsk drstlqvlds atgnwfsacf dnftealaet acrqmgyssk ptfraveigp
      121 dqdldvveit ensqelrmrn ssgpclsgsl vslhclacgk slktprvvgg eeasvdswpw
      181 qvsiqydkqh vcggsildph wvltaahcfr khtdvfnwkv ragsdklgsf pslavakiii
      241 iefnpmypkd ndialmklqf pltfsgtvrp iclpffdeel tpatplwiig wgftkqnggk
      301 msdillqasv qvidstrcna ddayqgevte kmmcagipeg gvdtcqgdsg gplmyqsdqw
      361 hvvgivswgy gcggpstpgv ytkvsaylnw iynvwkdrti qrscnspgtg lviqqpavpl
      421 melrsarhth rlitcvcfls fpalqplspl cpfpwd
//
LOCUS       XP_054225336             454 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protease serine 4 isoform X6 [Homo sapiens].
ACCESSION   XP_054225336
VERSION     XP_054225336.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369361.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..454
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..454
                     /product="transmembrane protease serine 4 isoform X6"
                     /calculated_mol_wt=49998
     Region          18..52
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(22,31,42..43)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(35,38,42,48..49)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            45..49
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          68..157
                     /region_name="SRCR_2"
                     /note="Scavenger receptor cysteine-rich domain; cl02509"
                     /db_xref="CDD:470597"
     Region          164..389
                     /region_name="Tryp_SPc"
                     /note="Trypsin-like serine protease; smart00020"
                     /db_xref="CDD:214473"
     Site            165
                     /site_type="active"
                     /note="cleavage site [active]"
                     /db_xref="CDD:238113"
     Site            order(205,250,347)
                     /site_type="active"
                     /db_xref="CDD:238113"
     Site            order(341,365,367)
                     /site_type="other"
                     /note="substrate binding sites [chemical binding]"
                     /db_xref="CDD:238113"
     CDS             1..454
                     /gene="TMPRSS4"
                     /gene_synonym="CAP2; CAPH2; MT-SP2; TMPRSS3"
                     /coded_by="XM_054369361.1:226..1590"
                     /db_xref="GeneID:56649"
                     /db_xref="HGNC:HGNC:11878"
                     /db_xref="MIM:606565"
ORIGIN      
        1 mdpdsdqpln slvkvildky yflcgqplhf iprkqlcdge ldcplgedee hcvksfpegp
       61 avavrlskdr stlqvldsat gnwfsacfdn ftealaetac rqmgysskpt fraveigpdq
      121 dldvveiten sqelrmrnss gpclsgslvs lhclacgksl ktprvvggee asvdswpwqv
      181 siqydkqhvc ggsildphwv ltaahcfrkh tdvfnwkvra gsdklgsfps lavakiiiie
      241 fnpmypkdnd ialmklqfpl tfsgtvrpic lpffdeeltp atplwiigwg ftkqnggkms
      301 dillqasvqv idstrcnadd ayqgevtekm mcagipeggv dtcqgdsggp lmyqsdqwhv
      361 vgivswgygc ggpstpgvyt kvsaylnwiy nvwkdrtiqr scnspgtglv iqqpavplme
      421 lrsarhthrl itcvcflsfp alqplsplcp fpwd
//
LOCUS       XP_054225337             430 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protease serine 4 isoform X7 [Homo sapiens].
ACCESSION   XP_054225337
VERSION     XP_054225337.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369362.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..430
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..430
                     /product="transmembrane protease serine 4 isoform X7"
                     /calculated_mol_wt=47272
     Region          56..90
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(60,69,80..81)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(73,76,80,86..87)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            83..87
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          106..190
                     /region_name="SRCR_2"
                     /note="Scavenger receptor cysteine-rich domain; cl02509"
                     /db_xref="CDD:470597"
     Region          197..422
                     /region_name="Tryp_SPc"
                     /note="Trypsin-like serine protease; smart00020"
                     /db_xref="CDD:214473"
     Site            198
                     /site_type="active"
                     /note="cleavage site [active]"
                     /db_xref="CDD:238113"
     Site            order(238,283,380)
                     /site_type="active"
                     /db_xref="CDD:238113"
     Site            order(374,398,400)
                     /site_type="other"
                     /note="substrate binding sites [chemical binding]"
                     /db_xref="CDD:238113"
     CDS             1..430
                     /gene="TMPRSS4"
                     /gene_synonym="CAP2; CAPH2; MT-SP2; TMPRSS3"
                     /coded_by="XM_054369362.1:226..1518"
                     /db_xref="GeneID:56649"
                     /db_xref="HGNC:HGNC:11878"
                     /db_xref="MIM:606565"
ORIGIN      
        1 mdpdsdqpln sldvkplrkp ripmetfrkv gipiiialls lasiiivvvl ikvildkyyf
       61 lcgqplhfip rkqlcdgeld cplgedeehc vksfpegpav avrlskdrst lqvldsatgn
      121 wfsacfdnft ealaetacrq mgysraveig pdqdldvvei tensqelrmr nssgpclsgs
      181 lvslhclacg kslktprvvg geeasvdswp wqvsiqydkq hvcggsildp hwvltaahcf
      241 rkhtdvfnwk vragsdklgs fpslavakii iiefnpmypk dndialmklq fpltfsgtvr
      301 piclpffdee ltpatplwii gwgftkqngg kmsdillqas vqvidstrcn addayqgevt
      361 ekmmcagipe ggvdtcqgds ggplmyqsdq whvvgivswg ygcggpstpg vytkvsayln
      421 wiynvwkael
//
LOCUS       XP_054225338             345 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protease serine 4 isoform X8 [Homo sapiens].
ACCESSION   XP_054225338
VERSION     XP_054225338.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369363.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..345
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..345
                     /product="transmembrane protease serine 4 isoform X8"
                     /calculated_mol_wt=38345
     Region          58..92
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(62,71,82..83)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(75,78,82,88..89)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            85..89
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          108..197
                     /region_name="SRCR_2"
                     /note="Scavenger receptor cysteine-rich domain; cl02509"
                     /db_xref="CDD:470597"
     Region          204..>304
                     /region_name="Tryp_SPc"
                     /note="Trypsin-like serine protease; smart00020"
                     /db_xref="CDD:214473"
     Site            205
                     /site_type="active"
                     /note="cleavage site [active]"
                     /db_xref="CDD:238113"
     CDS             1..345
                     /gene="TMPRSS4"
                     /gene_synonym="CAP2; CAPH2; MT-SP2; TMPRSS3"
                     /coded_by="XM_054369363.1:226..1263"
                     /db_xref="GeneID:56649"
                     /db_xref="HGNC:HGNC:11878"
                     /db_xref="MIM:606565"
ORIGIN      
        1 mlqdpdsdqp lnsldvkplr kpripmetfr kvgipiiial lslasiiivv vlikvildky
       61 yflcgqplhf iprkqlcdge ldcplgedee hcvksfpegp avavrlskdr stlqvldsat
      121 gnwfsacfdn ftealaetac rqmgysskpt fraveigpdq dldvveiten sqelrmrnss
      181 gpclsgslvs lhclacgksl ktprvvggee asvdswpwqv siqydkqhvc ggsildphwv
      241 ltaahcfrkh tdvfnwkvra gsdklgsfps lavakiiiie fnpmypkdnd ialmklqfpl
      301 tfsdqdsqlw gpqdtgplek rgfhcqislg nifilqlpsw ntlvy
//
LOCUS       XP_054225339             254 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protease serine 4 isoform X9 [Homo sapiens].
ACCESSION   XP_054225339
VERSION     XP_054225339.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369364.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..254
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..254
                     /product="transmembrane protease serine 4 isoform X9"
                     /calculated_mol_wt=28088
     Region          58..92
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(62,71,82..83)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(75,78,82,88..89)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            85..89
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          108..197
                     /region_name="SRCR_2"
                     /note="Scavenger receptor cysteine-rich domain; cl02509"
                     /db_xref="CDD:470597"
     CDS             1..254
                     /gene="TMPRSS4"
                     /gene_synonym="CAP2; CAPH2; MT-SP2; TMPRSS3"
                     /coded_by="XM_054369364.1:226..990"
                     /db_xref="GeneID:56649"
                     /db_xref="HGNC:HGNC:11878"
                     /db_xref="MIM:606565"
ORIGIN      
        1 mlqdpdsdqp lnsldvkplr kpripmetfr kvgipiiial lslasiiivv vlikvildky
       61 yflcgqplhf iprkqlcdge ldcplgedee hcvksfpegp avavrlskdr stlqvldsat
      121 gnwfsacfdn ftealaetac rqmgysskpt fraveigpdq dldvveiten sqelrmrnss
      181 gpclsgslvs lhclacgnsr ereiprdwgp rlntekcicr lkeekpmsvc lahhslpaps
      241 tapgqraldt swld
//
LOCUS       XP_054225340             210 aa            linear   PRI 05-AUG-2025
DEFINITION  A-kinase-interacting protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_054225340
VERSION     XP_054225340.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369365.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..210
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..210
                     /product="A-kinase-interacting protein 1 isoform X1"
                     /calculated_mol_wt=22983
     CDS             1..210
                     /gene="AKIP1"
                     /gene_synonym="BCA3; C11orf17"
                     /coded_by="XM_054369365.1:92..724"
                     /db_xref="GeneID:56672"
                     /db_xref="HGNC:HGNC:1170"
                     /db_xref="MIM:609191"
ORIGIN      
        1 mdnclaaaal ngvdrrslqr sarlalevle rakrravdwh alerpkgcmg vlareaphle
       61 kqpaagpqrv lpgereerpp tlsasfrtma efmdytssqc gkyyssvpee ggathvyryh
      121 rgesklhmcl digngqrkdr kktslgpggs yqisehapea sqpaeniskd lyievypgty
      181 svtvgsndlt kkthvvavds gqsvdlvfpv
//
LOCUS       XP_054225341             183 aa            linear   PRI 05-AUG-2025
DEFINITION  A-kinase-interacting protein 1 isoform X2 [Homo sapiens].
ACCESSION   XP_054225341
VERSION     XP_054225341.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369366.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..183
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..183
                     /product="A-kinase-interacting protein 1 isoform X2"
                     /calculated_mol_wt=19903
     CDS             1..183
                     /gene="AKIP1"
                     /gene_synonym="BCA3; C11orf17"
                     /coded_by="XM_054369366.1:104..655"
                     /db_xref="GeneID:56672"
                     /db_xref="HGNC:HGNC:1170"
                     /db_xref="MIM:609191"
ORIGIN      
        1 mdnclaaaal ngvdrrslqr sarlalevle rakrravdwh alerpkgcmg vlareaphle
       61 kqpaagpqrv lpgekyyssv peeggathvy ryhrgesklh mcldigngqr kdrkktslgp
      121 ggsyqiseha peasqpaeni skdlyievyp gtysvtvgsn dltkkthvva vdsgqsvdlv
      181 fpv
//
LOCUS       XP_054225342             173 aa            linear   PRI 05-AUG-2025
DEFINITION  nuclear receptor-interacting protein 3 isoform X1 [Homo sapiens].
ACCESSION   XP_054225342
VERSION     XP_054225342.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369367.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..173
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..173
                     /product="nuclear receptor-interacting protein 3 isoform
                     X1"
                     /calculated_mol_wt=19021
     Region          42..144
                     /region_name="NRIP_C"
                     /note="putative nuclear receptor interacting protein;
                     cd05480"
                     /db_xref="CDD:133147"
     Site            56..58
                     /site_type="active"
                     /note="catalytic motif [active]"
                     /db_xref="CDD:133147"
     Site            56
                     /site_type="active"
                     /note="Catalytic residue [active]"
                     /db_xref="CDD:133147"
     CDS             1..173
                     /gene="NRIP3"
                     /gene_synonym="C11orf14; NY-SAR-105"
                     /coded_by="XM_054369367.1:54..575"
                     /db_xref="GeneID:56675"
                     /db_xref="HGNC:HGNC:1167"
                     /db_xref="MIM:613125"
ORIGIN      
        1 metnlsklrs gprvpwaskt nklnqakseg lkkseeddmi lvscqcagkd vkalvdtgcl
       61 ynlislacvd rlglkehvks hkhegeklsl prhlkvvgqi ehlvitlgsl rldcpaavvd
      121 dneknlslgl qtlrslkcii nldkhrlimg ktdkeeipfv etvslnednt sea
//
LOCUS       XP_054225343             141 aa            linear   PRI 05-AUG-2025
DEFINITION  nuclear receptor-interacting protein 3 isoform X2 [Homo sapiens].
ACCESSION   XP_054225343
VERSION     XP_054225343.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369368.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..141
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..141
                     /product="nuclear receptor-interacting protein 3 isoform
                     X2"
                     /calculated_mol_wt=15634
     Region          110..>141
                     /region_name="pepsin_retropepsin_like"
                     /note="Cellular and retroviral pepsin-like aspartate
                     proteases; cl11403"
                     /db_xref="CDD:472175"
     Site            124..126
                     /site_type="active"
                     /note="catalytic motif [active]"
                     /db_xref="CDD:133147"
     Site            124
                     /site_type="active"
                     /note="Catalytic residue [active]"
                     /db_xref="CDD:133147"
     CDS             1..141
                     /gene="NRIP3"
                     /gene_synonym="C11orf14; NY-SAR-105"
                     /coded_by="XM_054369368.1:67..492"
                     /db_xref="GeneID:56675"
                     /db_xref="HGNC:HGNC:1167"
                     /db_xref="MIM:613125"
ORIGIN      
        1 mfysgllteg grketdmrea aslrqqrrmk qavqfihkds adllpldglk klgsskdmqp
       61 hnilqrrlme tnlsklrsgp rvpwasktnk lnqakseglk kseeddmilv scqcagkdvk
      121 alvdtgclyn lislacvdrl g
//
LOCUS       XP_054225344             423 aa            linear   PRI 05-AUG-2025
DEFINITION  integral membrane protein GPR137 isoform X1 [Homo sapiens].
ACCESSION   XP_054225344
VERSION     XP_054225344.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369369.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..423
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..423
                     /product="integral membrane protein GPR137 isoform X1"
                     /calculated_mol_wt=46543
     Region          22..331
                     /region_name="7tm_GPR137A"
                     /note="Integral membrane protein GPR137A, an orphan
                     receptor member of the seven-transmembrane G
                     protein-coupled receptor superfamily; cd21474"
                     /db_xref="CDD:410551"
     Region          33..55
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:410551"
     Region          67..87
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:410551"
     Region          102..124
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:410551"
     Region          145..167
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:410551"
     Region          182..204
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:410551"
     Region          226..248
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:410551"
     Region          279..301
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:410551"
     CDS             1..423
                     /gene="GPR137"
                     /gene_synonym="C11orf4; GPR137A; TM7SF1L1"
                     /coded_by="XM_054369369.1:129..1400"
                     /db_xref="GeneID:56834"
                     /db_xref="HGNC:HGNC:24300"
ORIGIN      
        1 maslpdmesn lsglvpaagl vpalppavtl gltaayttly allffsvyaq lwlvllyghk
       61 rlsyqtvfla lcllwaalrt tlfsfyfrdt pranrlgplp fwllyccpvc lqfftltlmn
      121 lyfaqvvfka kvkrrpemsr gllavrgafv gasllfllvn vlcavlshrr raqpwalllv
      181 rvlvsdslfv icalslaacl clvarrapst siyleakgts vcqaaamgga mvllyasrac
      241 ynltalalap qsrldtfdyd wynvsdqadl vndlgnkgyl vfglilfvwe llpttllvgf
      301 frvhrppqdl stshilngqv fasrsyffdr aghcedegcs wehsrgestr cqdqaatttv
      361 stpphrrdpp pspteypgps pphprplcqv clpllaqdpg grgypllwpa pccschselv
      421 psp
//
LOCUS       XP_054225345             417 aa            linear   PRI 05-AUG-2025
DEFINITION  integral membrane protein GPR137 isoform X2 [Homo sapiens].
ACCESSION   XP_054225345
VERSION     XP_054225345.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369370.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..417
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..417
                     /product="integral membrane protein GPR137 isoform X2"
                     /calculated_mol_wt=45928
     Region          16..325
                     /region_name="7tm_GPR137A"
                     /note="Integral membrane protein GPR137A, an orphan
                     receptor member of the seven-transmembrane G
                     protein-coupled receptor superfamily; cd21474"
                     /db_xref="CDD:410551"
     Region          27..49
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:410551"
     Region          61..81
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:410551"
     Region          96..118
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:410551"
     Region          139..161
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:410551"
     Region          176..198
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:410551"
     Region          220..242
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:410551"
     Region          273..295
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:410551"
     CDS             1..417
                     /gene="GPR137"
                     /gene_synonym="C11orf4; GPR137A; TM7SF1L1"
                     /coded_by="XM_054369370.1:119..1372"
                     /db_xref="GeneID:56834"
                     /db_xref="HGNC:HGNC:24300"
ORIGIN      
        1 mesnlsglvp aaglvpalpp avtlgltaay ttlyallffs vyaqlwlvll yghkrlsyqt
       61 vflalcllwa alrttlfsfy frdtpranrl gplpfwllyc cpvclqfftl tlmnlyfaqv
      121 vfkakvkrrp emsrgllavr gafvgasllf llvnvlcavl shrrraqpwa lllvrvlvsd
      181 slfvicalsl aaclclvarr apstsiylea kgtsvcqaaa mggamvllya sracynltal
      241 alapqsrldt fdydwynvsd qadlvndlgn kgylvfglil fvwellpttl lvgffrvhrp
      301 pqdlstshil ngqvfasrsy ffdraghced egcswehsrg estrcqdqaa tttvstpphr
      361 rdpppsptey pgpspphprp lcqvclplla qdpggrgypl lwpapccsch selvpsp
//
LOCUS       XP_054225346             417 aa            linear   PRI 05-AUG-2025
DEFINITION  integral membrane protein GPR137 isoform X2 [Homo sapiens].
ACCESSION   XP_054225346
VERSION     XP_054225346.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369371.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..417
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..417
                     /product="integral membrane protein GPR137 isoform X2"
                     /calculated_mol_wt=45928
     Region          16..325
                     /region_name="7tm_GPR137A"
                     /note="Integral membrane protein GPR137A, an orphan
                     receptor member of the seven-transmembrane G
                     protein-coupled receptor superfamily; cd21474"
                     /db_xref="CDD:410551"
     Region          27..49
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:410551"
     Region          61..81
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:410551"
     Region          96..118
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:410551"
     Region          139..161
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:410551"
     Region          176..198
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:410551"
     Region          220..242
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:410551"
     Region          273..295
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:410551"
     CDS             1..417
                     /gene="GPR137"
                     /gene_synonym="C11orf4; GPR137A; TM7SF1L1"
                     /coded_by="XM_054369371.1:254..1507"
                     /db_xref="GeneID:56834"
                     /db_xref="HGNC:HGNC:24300"
ORIGIN      
        1 mesnlsglvp aaglvpalpp avtlgltaay ttlyallffs vyaqlwlvll yghkrlsyqt
       61 vflalcllwa alrttlfsfy frdtpranrl gplpfwllyc cpvclqfftl tlmnlyfaqv
      121 vfkakvkrrp emsrgllavr gafvgasllf llvnvlcavl shrrraqpwa lllvrvlvsd
      181 slfvicalsl aaclclvarr apstsiylea kgtsvcqaaa mggamvllya sracynltal
      241 alapqsrldt fdydwynvsd qadlvndlgn kgylvfglil fvwellpttl lvgffrvhrp
      301 pqdlstshil ngqvfasrsy ffdraghced egcswehsrg estrcqdqaa tttvstpphr
      361 rdpppsptey pgpspphprp lcqvclplla qdpggrgypl lwpapccsch selvpsp
//
LOCUS       XP_054225347             417 aa            linear   PRI 05-AUG-2025
DEFINITION  integral membrane protein GPR137 isoform X2 [Homo sapiens].
ACCESSION   XP_054225347
VERSION     XP_054225347.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369372.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..417
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..417
                     /product="integral membrane protein GPR137 isoform X2"
                     /calculated_mol_wt=45928
     Region          16..325
                     /region_name="7tm_GPR137A"
                     /note="Integral membrane protein GPR137A, an orphan
                     receptor member of the seven-transmembrane G
                     protein-coupled receptor superfamily; cd21474"
                     /db_xref="CDD:410551"
     Region          27..49
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:410551"
     Region          61..81
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:410551"
     Region          96..118
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:410551"
     Region          139..161
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:410551"
     Region          176..198
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:410551"
     Region          220..242
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:410551"
     Region          273..295
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:410551"
     CDS             1..417
                     /gene="GPR137"
                     /gene_synonym="C11orf4; GPR137A; TM7SF1L1"
                     /coded_by="XM_054369372.1:117..1370"
                     /db_xref="GeneID:56834"
                     /db_xref="HGNC:HGNC:24300"
ORIGIN      
        1 mesnlsglvp aaglvpalpp avtlgltaay ttlyallffs vyaqlwlvll yghkrlsyqt
       61 vflalcllwa alrttlfsfy frdtpranrl gplpfwllyc cpvclqfftl tlmnlyfaqv
      121 vfkakvkrrp emsrgllavr gafvgasllf llvnvlcavl shrrraqpwa lllvrvlvsd
      181 slfvicalsl aaclclvarr apstsiylea kgtsvcqaaa mggamvllya sracynltal
      241 alapqsrldt fdydwynvsd qadlvndlgn kgylvfglil fvwellpttl lvgffrvhrp
      301 pqdlstshil ngqvfasrsy ffdraghced egcswehsrg estrcqdqaa tttvstpphr
      361 rdpppsptey pgpspphprp lcqvclplla qdpggrgypl lwpapccsch selvpsp
//
LOCUS       XP_054225348             417 aa            linear   PRI 05-AUG-2025
DEFINITION  integral membrane protein GPR137 isoform X2 [Homo sapiens].
ACCESSION   XP_054225348
VERSION     XP_054225348.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369373.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..417
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..417
                     /product="integral membrane protein GPR137 isoform X2"
                     /calculated_mol_wt=45928
     Region          16..325
                     /region_name="7tm_GPR137A"
                     /note="Integral membrane protein GPR137A, an orphan
                     receptor member of the seven-transmembrane G
                     protein-coupled receptor superfamily; cd21474"
                     /db_xref="CDD:410551"
     Region          27..49
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:410551"
     Region          61..81
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:410551"
     Region          96..118
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:410551"
     Region          139..161
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:410551"
     Region          176..198
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:410551"
     Region          220..242
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:410551"
     Region          273..295
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:410551"
     CDS             1..417
                     /gene="GPR137"
                     /gene_synonym="C11orf4; GPR137A; TM7SF1L1"
                     /coded_by="XM_054369373.1:403..1656"
                     /db_xref="GeneID:56834"
                     /db_xref="HGNC:HGNC:24300"
ORIGIN      
        1 mesnlsglvp aaglvpalpp avtlgltaay ttlyallffs vyaqlwlvll yghkrlsyqt
       61 vflalcllwa alrttlfsfy frdtpranrl gplpfwllyc cpvclqfftl tlmnlyfaqv
      121 vfkakvkrrp emsrgllavr gafvgasllf llvnvlcavl shrrraqpwa lllvrvlvsd
      181 slfvicalsl aaclclvarr apstsiylea kgtsvcqaaa mggamvllya sracynltal
      241 alapqsrldt fdydwynvsd qadlvndlgn kgylvfglil fvwellpttl lvgffrvhrp
      301 pqdlstshil ngqvfasrsy ffdraghced egcswehsrg estrcqdqaa tttvstpphr
      361 rdpppsptey pgpspphprp lcqvclplla qdpggrgypl lwpapccsch selvpsp
//
LOCUS       XP_054225349             373 aa            linear   PRI 05-AUG-2025
DEFINITION  integral membrane protein GPR137 isoform X3 [Homo sapiens].
ACCESSION   XP_054225349
VERSION     XP_054225349.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369374.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..373
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..373
                     /product="integral membrane protein GPR137 isoform X3"
                     /calculated_mol_wt=41167
     Region          22..281
                     /region_name="7tm_GPCRs"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; cl28897"
                     /db_xref="CDD:475119"
     Region          33..55
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:410551"
     Region          67..87
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:410551"
     Region          102..124
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:410551"
     Region          145..167
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:410551"
     Region          182..204
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:410551"
     Region          229..251
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:410551"
     CDS             1..373
                     /gene="GPR137"
                     /gene_synonym="C11orf4; GPR137A; TM7SF1L1"
                     /coded_by="XM_054369374.1:129..1250"
                     /db_xref="GeneID:56834"
                     /db_xref="HGNC:HGNC:24300"
ORIGIN      
        1 maslpdmesn lsglvpaagl vpalppavtl gltaayttly allffsvyaq lwlvllyghk
       61 rlsyqtvfla lcllwaalrt tlfsfyfrdt pranrlgplp fwllyccpvc lqfftltlmn
      121 lyfaqvvfka kvkrrpemsr gllavrgafv gasllfllvn vlcavlshrr raqpwalllv
      181 rvlvsdslfv icalslaacl clvarrapst siyleakadl vndlgnkgyl vfglilfvwe
      241 llpttllvgf frvhrppqdl stshilngqv fasrsyffdr aghcedegcs wehsrgestr
      301 cqdqaatttv stpphrrdpp pspteypgps pphprplcqv clpllaqdpg grgypllwpa
      361 pccschselv psp
//
LOCUS       XP_054225350             346 aa            linear   PRI 05-AUG-2025
DEFINITION  integral membrane protein GPR137 isoform X4 [Homo sapiens].
ACCESSION   XP_054225350
VERSION     XP_054225350.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369375.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..346
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..346
                     /product="integral membrane protein GPR137 isoform X4"
                     /calculated_mol_wt=38125
     Region          16..275
                     /region_name="7tm_GPCRs"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; cl28897"
                     /db_xref="CDD:475119"
     Region          27..49
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:410550"
     Region          61..81
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:410550"
     Region          96..118
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:410550"
     Region          139..161
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:410550"
     Region          176..198
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:410550"
     Region          223..245
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:410550"
     CDS             1..346
                     /gene="GPR137"
                     /gene_synonym="C11orf4; GPR137A; TM7SF1L1"
                     /coded_by="XM_054369375.1:254..1294"
                     /db_xref="GeneID:56834"
                     /db_xref="HGNC:HGNC:24300"
ORIGIN      
        1 mesnlsglvp aaglvpalpp avtlgltaay ttlyallffs vyaqlwlvll yghkrlsyqt
       61 vflalcllwa alrttlfsfy frdtpranrl gplpfwllyc cpvclqfftl tlmnlyfaqv
      121 vfkakvkrrp emsrgllavr gafvgasllf llvnvlcavl shrrraqpwa lllvrvlvsd
      181 slfvicalsl aaclclvarr apstsiylea kadlvndlgn kgylvfglil fvwellpttl
      241 lvgffrvhrp pqdlstshil ngqvfasrsy ffdraghced egcswehsrg estsmsgslg
      301 sgswygaigr epgwyggsqt kttpllfsqv pgpgghhhsl ystpqt
//
LOCUS       XP_054225351             276 aa            linear   PRI 05-AUG-2025
DEFINITION  integral membrane protein GPR137 isoform X5 [Homo sapiens].
ACCESSION   XP_054225351
VERSION     XP_054225351.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369376.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..276
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..276
                     /product="integral membrane protein GPR137 isoform X5"
                     /calculated_mol_wt=30863
     Region          22..260
                     /region_name="7tm_GPCRs"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; cl28897"
                     /db_xref="CDD:475119"
     Region          33..55
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:410550"
     Region          67..87
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:410550"
     Region          102..124
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:410550"
     Region          145..167
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:410550"
     Region          182..204
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:410550"
     Region          229..251
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:410550"
     CDS             1..276
                     /gene="GPR137"
                     /gene_synonym="C11orf4; GPR137A; TM7SF1L1"
                     /coded_by="XM_054369376.1:129..959"
                     /db_xref="GeneID:56834"
                     /db_xref="HGNC:HGNC:24300"
ORIGIN      
        1 maslpdmesn lsglvpaagl vpalppavtl gltaayttly allffsvyaq lwlvllyghk
       61 rlsyqtvfla lcllwaalrt tlfsfyfrdt pranrlgplp fwllyccpvc lqfftltlmn
      121 lyfaqvvfka kvkrrpemsr gllavrgafv gasllfllvn vlcavlshrr raqpwalllv
      181 rvlvsdslfv icalslaacl clvarrapst siyleakadl vndlgnkgyl vfglilfvwe
      241 llpttllvgf frvhrppqdl yvgqsrlwel vwchra
//
LOCUS       XP_054225352             270 aa            linear   PRI 05-AUG-2025
DEFINITION  integral membrane protein GPR137 isoform X6 [Homo sapiens].
ACCESSION   XP_054225352
VERSION     XP_054225352.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369377.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..270
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..270
                     /product="integral membrane protein GPR137 isoform X6"
                     /calculated_mol_wt=30248
     Region          16..254
                     /region_name="7tm_GPCRs"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; cl28897"
                     /db_xref="CDD:475119"
     Region          27..49
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:410550"
     Region          61..81
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:410550"
     Region          96..118
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:410550"
     Region          139..161
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:410550"
     Region          176..198
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:410550"
     Region          223..245
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:410550"
     CDS             1..270
                     /gene="GPR137"
                     /gene_synonym="C11orf4; GPR137A; TM7SF1L1"
                     /coded_by="XM_054369377.1:119..931"
                     /db_xref="GeneID:56834"
                     /db_xref="HGNC:HGNC:24300"
ORIGIN      
        1 mesnlsglvp aaglvpalpp avtlgltaay ttlyallffs vyaqlwlvll yghkrlsyqt
       61 vflalcllwa alrttlfsfy frdtpranrl gplpfwllyc cpvclqfftl tlmnlyfaqv
      121 vfkakvkrrp emsrgllavr gafvgasllf llvnvlcavl shrrraqpwa lllvrvlvsd
      181 slfvicalsl aaclclvarr apstsiylea kadlvndlgn kgylvfglil fvwellpttl
      241 lvgffrvhrp pqdlyvgqsr lwelvwchra
//
LOCUS       XP_054225353             355 aa            linear   PRI 05-AUG-2025
DEFINITION  intraflagellar transport protein 46 homolog isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225353
VERSION     XP_054225353.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369378.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..355
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..355
                     /product="intraflagellar transport protein 46 homolog
                     isoform X1"
                     /calculated_mol_wt=39933
     Region          116..318
                     /region_name="IFT46_B_C"
                     /note="Intraflagellar transport complex B protein 46 C
                     terminal; pfam12317"
                     /db_xref="CDD:463532"
     CDS             1..355
                     /gene="IFT46"
                     /gene_synonym="C11orf2; C11orf60; CFAP32; FAP32"
                     /coded_by="XM_054369378.1:4440..5507"
                     /db_xref="GeneID:56912"
                     /db_xref="HGNC:HGNC:26146"
                     /db_xref="MIM:620506"
ORIGIN      
        1 madnssdece eennkvlreg mpqapghrgk dmdpvppapa slkchqtpsh vlervgwyre
       61 sqkhrkekkk tsqltpqrgf senedddddd ddssetdsds ddddeehgap legaydpady
      121 ehlpvsaeik elfqyisryt pqlidldhkl kpfipdfipa vgdidaflkv prpdgkpdnl
      181 gllvldepst kqsdptvlsl wltenskqhn itqhmkvksl edaeknpkai dtwiesisel
      241 hrskppatvh ytrpmpdidt lmqewspefe ellgkvslpt aeidcslaey idmicaildi
      301 pvyksriqsl hllfslysef knsqhfkala egkkaftpss nstsqagdme tltfs
//
LOCUS       XP_054225354             355 aa            linear   PRI 05-AUG-2025
DEFINITION  intraflagellar transport protein 46 homolog isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225354
VERSION     XP_054225354.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369379.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..355
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..355
                     /product="intraflagellar transport protein 46 homolog
                     isoform X1"
                     /calculated_mol_wt=39933
     Region          116..318
                     /region_name="IFT46_B_C"
                     /note="Intraflagellar transport complex B protein 46 C
                     terminal; pfam12317"
                     /db_xref="CDD:463532"
     CDS             1..355
                     /gene="IFT46"
                     /gene_synonym="C11orf2; C11orf60; CFAP32; FAP32"
                     /coded_by="XM_054369379.1:178..1245"
                     /db_xref="GeneID:56912"
                     /db_xref="HGNC:HGNC:26146"
                     /db_xref="MIM:620506"
ORIGIN      
        1 madnssdece eennkvlreg mpqapghrgk dmdpvppapa slkchqtpsh vlervgwyre
       61 sqkhrkekkk tsqltpqrgf senedddddd ddssetdsds ddddeehgap legaydpady
      121 ehlpvsaeik elfqyisryt pqlidldhkl kpfipdfipa vgdidaflkv prpdgkpdnl
      181 gllvldepst kqsdptvlsl wltenskqhn itqhmkvksl edaeknpkai dtwiesisel
      241 hrskppatvh ytrpmpdidt lmqewspefe ellgkvslpt aeidcslaey idmicaildi
      301 pvyksriqsl hllfslysef knsqhfkala egkkaftpss nstsqagdme tltfs
//
LOCUS       XP_054225355             304 aa            linear   PRI 05-AUG-2025
DEFINITION  intraflagellar transport protein 46 homolog isoform X2 [Homo
            sapiens].
ACCESSION   XP_054225355
VERSION     XP_054225355.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369380.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..304
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..304
                     /product="intraflagellar transport protein 46 homolog
                     isoform X2"
                     /calculated_mol_wt=34155
     Region          65..267
                     /region_name="IFT46_B_C"
                     /note="Intraflagellar transport complex B protein 46 C
                     terminal; pfam12317"
                     /db_xref="CDD:463532"
     CDS             1..304
                     /gene="IFT46"
                     /gene_synonym="C11orf2; C11orf60; CFAP32; FAP32"
                     /coded_by="XM_054369380.1:4440..5354"
                     /db_xref="GeneID:56912"
                     /db_xref="HGNC:HGNC:26146"
                     /db_xref="MIM:620506"
ORIGIN      
        1 madnssdece eennkekkkt sqltpqrgfs eneddddddd dssetdsdsd dddeehgapl
       61 egaydpadye hlpvsaeike lfqyisrytp qlidldhklk pfipdfipav gdidaflkvp
      121 rpdgkpdnlg llvldepstk qsdptvlslw ltenskqhni tqhmkvksle daeknpkaid
      181 twiesiselh rskppatvhy trpmpdidtl mqewspefee llgkvslpta eidcslaeyi
      241 dmicaildip vyksriqslh llfslysefk nsqhfkalae gkkaftpssn stsqagdmet
      301 ltfs
//
LOCUS       XP_054225356             304 aa            linear   PRI 05-AUG-2025
DEFINITION  intraflagellar transport protein 46 homolog isoform X2 [Homo
            sapiens].
ACCESSION   XP_054225356
VERSION     XP_054225356.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369381.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..304
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..304
                     /product="intraflagellar transport protein 46 homolog
                     isoform X2"
                     /calculated_mol_wt=34155
     Region          65..267
                     /region_name="IFT46_B_C"
                     /note="Intraflagellar transport complex B protein 46 C
                     terminal; pfam12317"
                     /db_xref="CDD:463532"
     CDS             1..304
                     /gene="IFT46"
                     /gene_synonym="C11orf2; C11orf60; CFAP32; FAP32"
                     /coded_by="XM_054369381.1:178..1092"
                     /db_xref="GeneID:56912"
                     /db_xref="HGNC:HGNC:26146"
                     /db_xref="MIM:620506"
ORIGIN      
        1 madnssdece eennkekkkt sqltpqrgfs eneddddddd dssetdsdsd dddeehgapl
       61 egaydpadye hlpvsaeike lfqyisrytp qlidldhklk pfipdfipav gdidaflkvp
      121 rpdgkpdnlg llvldepstk qsdptvlslw ltenskqhni tqhmkvksle daeknpkaid
      181 twiesiselh rskppatvhy trpmpdidtl mqewspefee llgkvslpta eidcslaeyi
      241 dmicaildip vyksriqslh llfslysefk nsqhfkalae gkkaftpssn stsqagdmet
      301 ltfs
//
LOCUS       XP_054225357             199 aa            linear   PRI 05-AUG-2025
DEFINITION  single-pass membrane and coiled-coil domain-containing protein 4
            isoform X1 [Homo sapiens].
ACCESSION   XP_054225357
VERSION     XP_054225357.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369382.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..199
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..199
                     /product="single-pass membrane and coiled-coil
                     domain-containing protein 4 isoform X1"
                     /calculated_mol_wt=21739
     CDS             1..199
                     /gene="SMCO4"
                     /gene_synonym="C11orf75; FN5"
                     /coded_by="XM_054369382.1:4..603"
                     /db_xref="GeneID:56935"
                     /db_xref="HGNC:HGNC:24810"
                     /db_xref="MIM:609477"
ORIGIN      
        1 mpaalevfrs cnagnqdvrl lkgeelpdrt wlcrankgit qvtctgnqfa einqrflklk
       61 kscslyrrfq pwqeecgpsw npsghtllas srkdaaaqre aqegdlqgqe gaeashaggp
      121 aadhysgtah agrgraldrg vcvrghaphh hrvspaagrg phrqgeeare gdankkwlsy
      181 semfmllsck qehpvfsgl
//
LOCUS       XP_054225358             194 aa            linear   PRI 05-AUG-2025
DEFINITION  single-pass membrane and coiled-coil domain-containing protein 4
            isoform X2 [Homo sapiens].
ACCESSION   XP_054225358
VERSION     XP_054225358.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369383.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..194
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..194
                     /product="single-pass membrane and coiled-coil
                     domain-containing protein 4 isoform X2"
                     /calculated_mol_wt=21186
     CDS             1..194
                     /gene="SMCO4"
                     /gene_synonym="C11orf75; FN5"
                     /coded_by="XM_054369383.1:4..588"
                     /db_xref="GeneID:56935"
                     /db_xref="HGNC:HGNC:24810"
                     /db_xref="MIM:609477"
ORIGIN      
        1 mpaalevfrs cnagnqdvrl lkgeelpdrt wlcrankgit qvtctgnqfa einqrflklk
       61 krrfqpwqee cgpswnpsgh tllassrkda aaqreaqegd lqgqegaeas haggpaadhy
      121 sgtahagrgr aldrgvcvrg haphhhrvsp aagrgphrqg eearegdank kwlsysemfm
      181 llsckqehpv fsgl
//
LOCUS       XP_054225359             165 aa            linear   PRI 05-AUG-2025
DEFINITION  single-pass membrane and coiled-coil domain-containing protein 4
            isoform X3 [Homo sapiens].
ACCESSION   XP_054225359
VERSION     XP_054225359.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369384.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..165
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..165
                     /product="single-pass membrane and coiled-coil
                     domain-containing protein 4 isoform X3"
                     /calculated_mol_wt=17946
     CDS             1..165
                     /gene="SMCO4"
                     /gene_synonym="C11orf75; FN5"
                     /coded_by="XM_054369384.1:267..764"
                     /db_xref="GeneID:56935"
                     /db_xref="HGNC:HGNC:24810"
                     /db_xref="MIM:609477"
ORIGIN      
        1 mypgitqvtc tgnqfaeinq rflklkkscs lyrrfqpwqe ecgpswnpsg htllassrkd
       61 aaaqreaqeg dlqgqegaea shaggpaadh ysgtahagrg raldrgvcvr ghaphhhrvs
      121 paagrgphrq geearegdan kkwlsysemf mllsckqehp vfsgl
//
LOCUS       XP_054225360             165 aa            linear   PRI 05-AUG-2025
DEFINITION  single-pass membrane and coiled-coil domain-containing protein 4
            isoform X3 [Homo sapiens].
ACCESSION   XP_054225360
VERSION     XP_054225360.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369385.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..165
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..165
                     /product="single-pass membrane and coiled-coil
                     domain-containing protein 4 isoform X3"
                     /calculated_mol_wt=17946
     CDS             1..165
                     /gene="SMCO4"
                     /gene_synonym="C11orf75; FN5"
                     /coded_by="XM_054369385.1:772..1269"
                     /db_xref="GeneID:56935"
                     /db_xref="HGNC:HGNC:24810"
                     /db_xref="MIM:609477"
ORIGIN      
        1 mypgitqvtc tgnqfaeinq rflklkkscs lyrrfqpwqe ecgpswnpsg htllassrkd
       61 aaaqreaqeg dlqgqegaea shaggpaadh ysgtahagrg raldrgvcvr ghaphhhrvs
      121 paagrgphrq geearegdan kkwlsysemf mllsckqehp vfsgl
//
LOCUS       XP_054225361             160 aa            linear   PRI 05-AUG-2025
DEFINITION  single-pass membrane and coiled-coil domain-containing protein 4
            isoform X4 [Homo sapiens].
ACCESSION   XP_054225361
VERSION     XP_054225361.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369386.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..160
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..160
                     /product="single-pass membrane and coiled-coil
                     domain-containing protein 4 isoform X4"
                     /calculated_mol_wt=17392
     CDS             1..160
                     /gene="SMCO4"
                     /gene_synonym="C11orf75; FN5"
                     /coded_by="XM_054369386.1:262..744"
                     /db_xref="GeneID:56935"
                     /db_xref="HGNC:HGNC:24810"
                     /db_xref="MIM:609477"
ORIGIN      
        1 mypgitqvtc tgnqfaeinq rflklkkrrf qpwqeecgps wnpsghtlla ssrkdaaaqr
       61 eaqegdlqgq egaeashagg paadhysgta hagrgraldr gvcvrghaph hhrvspaagr
      121 gphrqgeear egdankkwls ysemfmllsc kqehpvfsgl
//
LOCUS       XP_054225362            1336 aa            linear   PRI 05-AUG-2025
DEFINITION  BRCA2-interacting transcriptional repressor EMSY isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225362
VERSION     XP_054225362.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369387.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1336
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1336
                     /product="BRCA2-interacting transcriptional repressor EMSY
                     isoform X1"
                     /calculated_mol_wt=142963
     Region          17..81
                     /region_name="ENT"
                     /note="ENT domain; pfam03735"
                     /db_xref="CDD:461032"
     Region          <483..584
                     /region_name="COG3889"
                     /note="Extracellular solute-binding protein, contains
                     Ig-fold domain [General function prediction only]"
                     /db_xref="CDD:443097"
     Region          <964..1135
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     CDS             1..1336
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /coded_by="XM_054369387.1:151..4161"
                     /db_xref="GeneID:56946"
                     /db_xref="HGNC:HGNC:18071"
                     /db_xref="MIM:608574"
ORIGIN      
        1 mpvvwptlld lsrdeckril rkleleayag visalraqgd ltkekkdllg elskvlsist
       61 erhraevrra vnderlttia hkmnlslylg erpsysmsgp nsssewsieg rrlvplmprl
      121 vpqtaftvta navanaaiqh naslpvpaet gskevvcysy tsttstptst pvpsgsiatv
      181 ksprpaspas nvvvlpsgst vyvksvscsd edekprkrrr tnssssspvv lkevpkavvp
      241 vsktitvpvs gspkmsnimq sianslpphm spvkitftkp stqttntttq kviivttsps
      301 stfvpnilsk shnyaavtkl vptsviastt qkppvvitas qsslvsnsss gsssstpspi
      361 pntvavtavv sstpsvvmst vaqgvstsai kmastrlpsp kslvsaptqi laqfpkqhqq
      421 spkqqlyqvq qqtqqqvaqp spvshqqqpq qsplppgikp tiqikqesgv kiitqqvqps
      481 kilpkpvtat lptssnspim vvssngaimt tklvttptgt qatytrptvs psigrmaatp
      541 gaatyvktts gsiitvvpks latlggkiis snivsgtttk ittipmtskp nvivvqkttg
      601 kgttiqglpg knvvttllna ggektiqtvp tgakpailta trpitkmivt qpkgigstvq
      661 paakiiptki vygqqgktqv likpkpvtfq atvvseqtrq lvtetlqqas rvaeagnssi
      721 qegkeepqny tdssssstes sqssqdsqpv vhviasrrqd wseheiamet sptiiyqdvs
      781 sesqsatsti kallelqqtt vkekleskpr qptidlsqma vpiqmtqekr hspespsiav
      841 veselvaeyi ttertdegte vafpllvshr sqpqqpsqpq rtllqhvaqs qtatqtsvvv
      901 ksipasspga ithimqqals shtaftkhse elgteegeve emdtldpqtg lfyrsaltqs
      961 qsakqqklsq ppleqtqlqv ktlqcfqtkq kqtihlqadq lqhklpqmpq lsirhqkltp
     1021 lqqeqaqpkp dvqhtqhpmv akdrqlptlm aqppqtvvqv lavkttqqlp klqqapnqpk
     1081 iyvqpqtpqs qmslpassek qtasqveqpi itqgssvtki tfegrqpptv tkitggssvp
     1141 kltspvtsis piqasektav sdilkmslme aqidtnvehm ivdppkkala tsmltgeags
     1201 lpsthmvvag manstpqqqk crescsspst vgsslttrki dppavpatgq fmriqnvgqk
     1261 kaeespaeii iqaipqyaip chsssnvvve psgllelnnf tsqqlddeet ameqdidsst
     1321 edgtepspsq ssaers
//
LOCUS       XP_054225363            1322 aa            linear   PRI 05-AUG-2025
DEFINITION  BRCA2-interacting transcriptional repressor EMSY isoform X2 [Homo
            sapiens].
ACCESSION   XP_054225363
VERSION     XP_054225363.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369388.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1322
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1322
                     /product="BRCA2-interacting transcriptional repressor EMSY
                     isoform X2"
                     /calculated_mol_wt=141404
     Region          17..81
                     /region_name="ENT"
                     /note="ENT domain; pfam03735"
                     /db_xref="CDD:461032"
     Region          <483..584
                     /region_name="COG3889"
                     /note="Extracellular solute-binding protein, contains
                     Ig-fold domain [General function prediction only]"
                     /db_xref="CDD:443097"
     Region          <950..1121
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     CDS             1..1322
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /coded_by="XM_054369388.1:151..4119"
                     /db_xref="GeneID:56946"
                     /db_xref="HGNC:HGNC:18071"
                     /db_xref="MIM:608574"
ORIGIN      
        1 mpvvwptlld lsrdeckril rkleleayag visalraqgd ltkekkdllg elskvlsist
       61 erhraevrra vnderlttia hkmnlslylg erpsysmsgp nsssewsieg rrlvplmprl
      121 vpqtaftvta navanaaiqh naslpvpaet gskevvcysy tsttstptst pvpsgsiatv
      181 ksprpaspas nvvvlpsgst vyvksvscsd edekprkrrr tnssssspvv lkevpkavvp
      241 vsktitvpvs gspkmsnimq sianslpphm spvkitftkp stqttntttq kviivttsps
      301 stfvpnilsk shnyaavtkl vptsviastt qkppvvitas qsslvsnsss gsssstpspi
      361 pntvavtavv sstpsvvmst vaqgvstsai kmastrlpsp kslvsaptqi laqfpkqhqq
      421 spkqqlyqvq qqtqqqvaqp spvshqqqpq qsplppgikp tiqikqesgv kiitqqvqps
      481 kilpkpvtat lptssnspim vvssngaimt tklvttptgt qatytrptvs psigrmaatp
      541 gaatyvktts gsiitvvpks latlggkiis snivsgtttk ittipmtskp nvivvqkttg
      601 kgttiqglpg knvvttllna ggektiqtvp tgakpailta trpitkmivt qpkgigstvq
      661 paakiiptki vygqqgktqv likpkpvtfq atvvseqtrq lvtetlqqas rvaeagnssi
      721 qegkeepqny tdssssstes sqssqdsqpv vhviasrrqd wseheiamet sptiiyqdvs
      781 sesqsatsti kallelqqtt vkekleskpr qptidlsqma vpiqmtqekr hspespsiav
      841 veselvaeyi ttvshrsqpq qpsqpqrtll qhvaqsqtat qtsvvvksip asspgaithi
      901 mqqalsshta ftkhseelgt eegeveemdt ldpqtglfyr saltqsqsak qqklsqpple
      961 qtqlqvktlq cfqtkqkqti hlqadqlqhk lpqmpqlsir hqkltplqqe qaqpkpdvqh
     1021 tqhpmvakdr qlptlmaqpp qtvvqvlavk ttqqlpklqq apnqpkiyvq pqtpqsqmsl
     1081 passekqtas qveqpiitqg ssvtkitfeg rqpptvtkit ggssvpklts pvtsispiqa
     1141 sektavsdil kmslmeaqid tnvehmivdp pkkalatsml tgeagslpst hmvvagmans
     1201 tpqqqkcres csspstvgss lttrkidppa vpatgqfmri qnvgqkkaee spaeiiiqai
     1261 pqyaipchss snvvvepsgl lelnnftsqq lddeetameq didsstedgt epspsqssae
     1321 rs
//
LOCUS       XP_054225364            1320 aa            linear   PRI 05-AUG-2025
DEFINITION  BRCA2-interacting transcriptional repressor EMSY isoform X3 [Homo
            sapiens].
ACCESSION   XP_054225364
VERSION     XP_054225364.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369389.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1320
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1320
                     /product="BRCA2-interacting transcriptional repressor EMSY
                     isoform X3"
                     /calculated_mol_wt=141274
     Region          17..81
                     /region_name="ENT"
                     /note="ENT domain; pfam03735"
                     /db_xref="CDD:461032"
     Region          <484..585
                     /region_name="COG3889"
                     /note="Extracellular solute-binding protein, contains
                     Ig-fold domain [General function prediction only]"
                     /db_xref="CDD:443097"
     Region          <965..1136
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     CDS             1..1320
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /coded_by="XM_054369389.1:151..4113"
                     /db_xref="GeneID:56946"
                     /db_xref="HGNC:HGNC:18071"
                     /db_xref="MIM:608574"
ORIGIN      
        1 mpvvwptlld lsrdeckril rkleleayag visalraqgd ltkekkdllg elskvlsist
       61 erhraevrra vnderlttia hkmnlslylg erpsysmsgp nsssewsieg rrlvplmprl
      121 vpqtaftvta navanaaiqh naslpvpaet gskevvvcys ytsttstpts tpvpsgsiat
      181 vksprpaspa snvvvlpsgs tvyvksvscs dedekprkrr rtnssssspv vlkevpkavv
      241 pvsktitvpv sgspkmsnim qsianslpph mspvkitftk pstqttnttt qkviivttsp
      301 sstfvpnils kshnyaavtk lvptsviast tqkppvvita sqsslvsnss sgsssstpsp
      361 ipntvavtav vsstpsvvms tvaqgvstsa ikmastrlps pkslvsaptq ilaqfpkqhq
      421 qspkqqlyqv qqqtqqqvaq pspvshqqqp qqsplppgik ptiqikqesg vkiitqqvqp
      481 skilpkpvta tlptssnspi mvvssngaim ttklvttptg tqatytrptv spsigrmaat
      541 pgaatyvktt sgsiitvvpk slatlggkii ssnivsgttt kittipmtsk pnvivvqktt
      601 gkgttiqglp gknvvttlln aggektiqtv ptgakpailt atrpitkmiv tqpkgigstv
      661 qpaakiiptk ivygqqgktq vlikpkpvtf qatvvseqtr qlvtetlqqa srvaeagnss
      721 iqegkeepqn ytdssssste ssqssqdsqp vvhviasrrq dwseheiame tsptiiyqdv
      781 ssesqsatst ikallelqqt tvkekleskp rqptidlsqm avpiqmtqek rhspespsia
      841 vveselvaey ittertdegt evafpllvsh rsqpqqpsqp qrtllqhvaq sqtatqtsvv
      901 vksipasspg aithimqqal sshtaftkhs eelgteegev eemdtldpqt glfyrsaltq
      961 sqsakqqkls qppleqtqlq vktlqcfqtk qkqtihlqad qlqhklpqmp qlsirhqklt
     1021 plqqeqaqpk pdvqhtqhpm vakdrqlptl maqppqtvvq vlavkttqql pklqqapnqp
     1081 kiyvqpqtpq sqmslpasse kqtasqveqp iitqgssvtk itfegrqppt vtkitggssv
     1141 pkltspvtsi spiqasekta vsdilkmslm eaqidtnveh mivdppkkal atsmltgeag
     1201 slpsthmvva gmanstpqqq kcrescssps tvgsslttrk idppavpatg qfmriqnvgq
     1261 kkaeespaei iiqvktkell spgyplevvf ylplslqgys svcyslslql qcgggaqwas
//
LOCUS       XP_054225365            1309 aa            linear   PRI 05-AUG-2025
DEFINITION  BRCA2-interacting transcriptional repressor EMSY isoform X4 [Homo
            sapiens].
ACCESSION   XP_054225365
VERSION     XP_054225365.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369390.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1309
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1309
                     /product="BRCA2-interacting transcriptional repressor EMSY
                     isoform X4"
                     /calculated_mol_wt=139878
     Region          17..86
                     /region_name="ENT"
                     /note="ENT domain; pfam03735"
                     /db_xref="CDD:461032"
     Region          <470..571
                     /region_name="COG3889"
                     /note="Extracellular solute-binding protein, contains
                     Ig-fold domain [General function prediction only]"
                     /db_xref="CDD:443097"
     Region          <937..1108
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     CDS             1..1309
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /coded_by="XM_054369390.1:151..4080"
                     /db_xref="GeneID:56946"
                     /db_xref="HGNC:HGNC:18071"
                     /db_xref="MIM:608574"
ORIGIN      
        1 mpvvwptlld lsrdeckril rkleleayag visalraqgd ltkekkdllg elskvlsist
       61 erhraevrra vnderlttia hnmsgpnsss ewsiegrrlv plmprlvpqt aftvtanava
      121 naaiqhnasl pvpaetgske vvvcysytst tstptstpvp sgsiatvksp rpaspasnvv
      181 vlpsgstvyv ksvscsdede kprkrrrtns sssspvvlke vpkavvpvsk titvpvsgsp
      241 kmsnimqsia nslpphmspv kitftkpstq ttntttqkvi ivttspsstf vpnilskshn
      301 yaavtklvpt sviasttqkp pvvitasqss lvsnsssgss sstpspipnt vavtavvsst
      361 psvvmstvaq gvstsaikma strlpspksl vsaptqilaq fpkqhqqspk qqlyqvqqqt
      421 qqqvaqpspv shqqqpqqsp lppgikptiq ikqesgvkii tqqvqpskil pkpvtatlpt
      481 ssnspimvvs sngaimttkl vttptgtqat ytrptvspsi grmaatpgaa tyvkttsgsi
      541 itvvpkslat lggkiissni vsgtttkitt ipmtskpnvi vvqkttgkgt tiqglpgknv
      601 vttllnagge ktiqtvptga kpailtatrp itkmivtqpk gigstvqpaa kiiptkivyg
      661 qqgktqvlik pkpvtfqatv vseqtrqlvt etlqqasrva eagnssiqeg keepqnytds
      721 sssstessqs sqdsqpvvhv iasrrqdwse heiametspt iiyqdvsses qsatstikal
      781 lelqqttvke kleskprqpt idlsqmavpi qmtqekrhsp espsiavves elvaeyittv
      841 shrsqpqqps qpqrtllqhv aqsqtatqts vvvksipass pgaithimqq alsshtaftk
      901 hseelgteeg eveemdtldp qtglfyrsal tqsqsakqqk lsqppleqtq lqvktlqcfq
      961 tkqkqtihlq adqlqhklpq mpqlsirhqk ltplqqeqaq pkpdvqhtqh pmvakdrqlp
     1021 tlmaqppqtv vqvlavkttq qlpklqqapn qpkiyvqpqt pqsqmslpas sekqtasqve
     1081 qpiitqgssv tkitfegrqp ptvtkitggs svpkltspvt sispiqasek tavsdilkms
     1141 lmeaqidtnv ehmivdppkk alatsmltge agslpsthmv vagmanstpq qqkcrescss
     1201 pstvgssltt rkidppavpa tgqfmriqnv gqkkaeespa eiiiqaipqy aipchsssnv
     1261 vvepsgllel nnftsqqldd eetameqdid sstedgteps psqssaers
//
LOCUS       XP_054225366            1308 aa            linear   PRI 05-AUG-2025
DEFINITION  BRCA2-interacting transcriptional repressor EMSY isoform X5 [Homo
            sapiens].
ACCESSION   XP_054225366
VERSION     XP_054225366.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369391.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1308
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1308
                     /product="BRCA2-interacting transcriptional repressor EMSY
                     isoform X5"
                     /calculated_mol_wt=139778
     Region          17..86
                     /region_name="ENT"
                     /note="ENT domain; pfam03735"
                     /db_xref="CDD:461032"
     Region          <469..570
                     /region_name="COG3889"
                     /note="Extracellular solute-binding protein, contains
                     Ig-fold domain [General function prediction only]"
                     /db_xref="CDD:443097"
     Region          <936..1107
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     CDS             1..1308
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /coded_by="XM_054369391.1:151..4077"
                     /db_xref="GeneID:56946"
                     /db_xref="HGNC:HGNC:18071"
                     /db_xref="MIM:608574"
ORIGIN      
        1 mpvvwptlld lsrdeckril rkleleayag visalraqgd ltkekkdllg elskvlsist
       61 erhraevrra vnderlttia hnmsgpnsss ewsiegrrlv plmprlvpqt aftvtanava
      121 naaiqhnasl pvpaetgske vvcysytstt stptstpvps gsiatvkspr paspasnvvv
      181 lpsgstvyvk svscsdedek prkrrrtnss ssspvvlkev pkavvpvskt itvpvsgspk
      241 msnimqsian slpphmspvk itftkpstqt tntttqkvii vttspsstfv pnilskshny
      301 aavtklvpts viasttqkpp vvitasqssl vsnsssgsss stpspipntv avtavvsstp
      361 svvmstvaqg vstsaikmas trlpspkslv saptqilaqf pkqhqqspkq qlyqvqqqtq
      421 qqvaqpspvs hqqqpqqspl ppgikptiqi kqesgvkiit qqvqpskilp kpvtatlpts
      481 snspimvvss ngaimttklv ttptgtqaty trptvspsig rmaatpgaat yvkttsgsii
      541 tvvpkslatl ggkiissniv sgtttkitti pmtskpnviv vqkttgkgtt iqglpgknvv
      601 ttllnaggek tiqtvptgak pailtatrpi tkmivtqpkg igstvqpaak iiptkivygq
      661 qgktqvlikp kpvtfqatvv seqtrqlvte tlqqasrvae agnssiqegk eepqnytdss
      721 ssstessqss qdsqpvvhvi asrrqdwseh eiametspti iyqdvssesq satstikall
      781 elqqttvkek leskprqpti dlsqmavpiq mtqekrhspe spsiavvese lvaeyittvs
      841 hrsqpqqpsq pqrtllqhva qsqtatqtsv vvksipassp gaithimqqa lsshtaftkh
      901 seelgteege veemdtldpq tglfyrsalt qsqsakqqkl sqppleqtql qvktlqcfqt
      961 kqkqtihlqa dqlqhklpqm pqlsirhqkl tplqqeqaqp kpdvqhtqhp mvakdrqlpt
     1021 lmaqppqtvv qvlavkttqq lpklqqapnq pkiyvqpqtp qsqmslpass ekqtasqveq
     1081 piitqgssvt kitfegrqpp tvtkitggss vpkltspvts ispiqasekt avsdilkmsl
     1141 meaqidtnve hmivdppkka latsmltgea gslpsthmvv agmanstpqq qkcrescssp
     1201 stvgsslttr kidppavpat gqfmriqnvg qkkaeespae iiiqaipqya ipchsssnvv
     1261 vepsglleln nftsqqldde etameqdids stedgtepsp sqssaers
//
LOCUS       XP_054225367            1306 aa            linear   PRI 05-AUG-2025
DEFINITION  BRCA2-interacting transcriptional repressor EMSY isoform X6 [Homo
            sapiens].
ACCESSION   XP_054225367
VERSION     XP_054225367.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369392.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1306
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1306
                     /product="BRCA2-interacting transcriptional repressor EMSY
                     isoform X6"
                     /calculated_mol_wt=139648
     Region          17..86
                     /region_name="ENT"
                     /note="ENT domain; pfam03735"
                     /db_xref="CDD:461032"
     Region          <470..571
                     /region_name="COG3889"
                     /note="Extracellular solute-binding protein, contains
                     Ig-fold domain [General function prediction only]"
                     /db_xref="CDD:443097"
     Region          <951..1122
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     CDS             1..1306
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /coded_by="XM_054369392.1:151..4071"
                     /db_xref="GeneID:56946"
                     /db_xref="HGNC:HGNC:18071"
                     /db_xref="MIM:608574"
ORIGIN      
        1 mpvvwptlld lsrdeckril rkleleayag visalraqgd ltkekkdllg elskvlsist
       61 erhraevrra vnderlttia hnmsgpnsss ewsiegrrlv plmprlvpqt aftvtanava
      121 naaiqhnasl pvpaetgske vvvcysytst tstptstpvp sgsiatvksp rpaspasnvv
      181 vlpsgstvyv ksvscsdede kprkrrrtns sssspvvlke vpkavvpvsk titvpvsgsp
      241 kmsnimqsia nslpphmspv kitftkpstq ttntttqkvi ivttspsstf vpnilskshn
      301 yaavtklvpt sviasttqkp pvvitasqss lvsnsssgss sstpspipnt vavtavvsst
      361 psvvmstvaq gvstsaikma strlpspksl vsaptqilaq fpkqhqqspk qqlyqvqqqt
      421 qqqvaqpspv shqqqpqqsp lppgikptiq ikqesgvkii tqqvqpskil pkpvtatlpt
      481 ssnspimvvs sngaimttkl vttptgtqat ytrptvspsi grmaatpgaa tyvkttsgsi
      541 itvvpkslat lggkiissni vsgtttkitt ipmtskpnvi vvqkttgkgt tiqglpgknv
      601 vttllnagge ktiqtvptga kpailtatrp itkmivtqpk gigstvqpaa kiiptkivyg
      661 qqgktqvlik pkpvtfqatv vseqtrqlvt etlqqasrva eagnssiqeg keepqnytds
      721 sssstessqs sqdsqpvvhv iasrrqdwse heiametspt iiyqdvsses qsatstikal
      781 lelqqttvke kleskprqpt idlsqmavpi qmtqekrhsp espsiavves elvaeyitte
      841 rtdegtevaf pllvshrsqp qqpsqpqrtl lqhvaqsqta tqtsvvvksi passpgaith
      901 imqqalssht aftkhseelg teegeveemd tldpqtglfy rsaltqsqsa kqqklsqppl
      961 eqtqlqvktl qcfqtkqkqt ihlqadqlqh klpqmpqlsi rhqkltplqq eqaqpkpdvq
     1021 htqhpmvakd rqlptlmaqp pqtvvqvlav kttqqlpklq qapnqpkiyv qpqtpqsqms
     1081 lpassekqta sqveqpiitq gssvtkitfe grqpptvtki tggssvpklt spvtsispiq
     1141 asektavsdi lkmslmeaqi dtnvehmivd ppkkalatsm ltgeagslps thmvvagman
     1201 stpqqqkcre scsspstvgs slttrkidpp avpatgqfmr iqnvgqkkae espaeiiiqv
     1261 ktkellspgy plevvfylpl slqgyssvcy slslqlqcgg gaqwas
//
LOCUS       XP_054225368            1306 aa            linear   PRI 05-AUG-2025
DEFINITION  BRCA2-interacting transcriptional repressor EMSY isoform X7 [Homo
            sapiens].
ACCESSION   XP_054225368
VERSION     XP_054225368.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369393.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1306
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1306
                     /product="BRCA2-interacting transcriptional repressor EMSY
                     isoform X7"
                     /calculated_mol_wt=139715
     Region          17..81
                     /region_name="ENT"
                     /note="ENT domain; pfam03735"
                     /db_xref="CDD:461032"
     Region          <484..585
                     /region_name="COG3889"
                     /note="Extracellular solute-binding protein, contains
                     Ig-fold domain [General function prediction only]"
                     /db_xref="CDD:443097"
     Region          <951..1122
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     CDS             1..1306
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /coded_by="XM_054369393.1:151..4071"
                     /db_xref="GeneID:56946"
                     /db_xref="HGNC:HGNC:18071"
                     /db_xref="MIM:608574"
ORIGIN      
        1 mpvvwptlld lsrdeckril rkleleayag visalraqgd ltkekkdllg elskvlsist
       61 erhraevrra vnderlttia hkmnlslylg erpsysmsgp nsssewsieg rrlvplmprl
      121 vpqtaftvta navanaaiqh naslpvpaet gskevvvcys ytsttstpts tpvpsgsiat
      181 vksprpaspa snvvvlpsgs tvyvksvscs dedekprkrr rtnssssspv vlkevpkavv
      241 pvsktitvpv sgspkmsnim qsianslpph mspvkitftk pstqttnttt qkviivttsp
      301 sstfvpnils kshnyaavtk lvptsviast tqkppvvita sqsslvsnss sgsssstpsp
      361 ipntvavtav vsstpsvvms tvaqgvstsa ikmastrlps pkslvsaptq ilaqfpkqhq
      421 qspkqqlyqv qqqtqqqvaq pspvshqqqp qqsplppgik ptiqikqesg vkiitqqvqp
      481 skilpkpvta tlptssnspi mvvssngaim ttklvttptg tqatytrptv spsigrmaat
      541 pgaatyvktt sgsiitvvpk slatlggkii ssnivsgttt kittipmtsk pnvivvqktt
      601 gkgttiqglp gknvvttlln aggektiqtv ptgakpailt atrpitkmiv tqpkgigstv
      661 qpaakiiptk ivygqqgktq vlikpkpvtf qatvvseqtr qlvtetlqqa srvaeagnss
      721 iqegkeepqn ytdssssste ssqssqdsqp vvhviasrrq dwseheiame tsptiiyqdv
      781 ssesqsatst ikallelqqt tvkekleskp rqptidlsqm avpiqmtqek rhspespsia
      841 vveselvaey ittvshrsqp qqpsqpqrtl lqhvaqsqta tqtsvvvksi passpgaith
      901 imqqalssht aftkhseelg teegeveemd tldpqtglfy rsaltqsqsa kqqklsqppl
      961 eqtqlqvktl qcfqtkqkqt ihlqadqlqh klpqmpqlsi rhqkltplqq eqaqpkpdvq
     1021 htqhpmvakd rqlptlmaqp pqtvvqvlav kttqqlpklq qapnqpkiyv qpqtpqsqms
     1081 lpassekqta sqveqpiitq gssvtkitfe grqpptvtki tggssvpklt spvtsispiq
     1141 asektavsdi lkmslmeaqi dtnvehmivd ppkkalatsm ltgeagslps thmvvagman
     1201 stpqqqkcre scsspstvgs slttrkidpp avpatgqfmr iqnvgqkkae espaeiiiqv
     1261 ktkellspgy plevvfylpl slqgyssvcy slslqlqcgg gaqwas
//
LOCUS       XP_054225369            1305 aa            linear   PRI 05-AUG-2025
DEFINITION  BRCA2-interacting transcriptional repressor EMSY isoform X8 [Homo
            sapiens].
ACCESSION   XP_054225369
VERSION     XP_054225369.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369394.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1305
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1305
                     /product="BRCA2-interacting transcriptional repressor EMSY
                     isoform X8"
                     /calculated_mol_wt=139549
     Region          17..86
                     /region_name="ENT"
                     /note="ENT domain; pfam03735"
                     /db_xref="CDD:461032"
     Region          <469..570
                     /region_name="COG3889"
                     /note="Extracellular solute-binding protein, contains
                     Ig-fold domain [General function prediction only]"
                     /db_xref="CDD:443097"
     Region          <950..1121
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     CDS             1..1305
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /coded_by="XM_054369394.1:151..4068"
                     /db_xref="GeneID:56946"
                     /db_xref="HGNC:HGNC:18071"
                     /db_xref="MIM:608574"
ORIGIN      
        1 mpvvwptlld lsrdeckril rkleleayag visalraqgd ltkekkdllg elskvlsist
       61 erhraevrra vnderlttia hnmsgpnsss ewsiegrrlv plmprlvpqt aftvtanava
      121 naaiqhnasl pvpaetgske vvcysytstt stptstpvps gsiatvkspr paspasnvvv
      181 lpsgstvyvk svscsdedek prkrrrtnss ssspvvlkev pkavvpvskt itvpvsgspk
      241 msnimqsian slpphmspvk itftkpstqt tntttqkvii vttspsstfv pnilskshny
      301 aavtklvpts viasttqkpp vvitasqssl vsnsssgsss stpspipntv avtavvsstp
      361 svvmstvaqg vstsaikmas trlpspkslv saptqilaqf pkqhqqspkq qlyqvqqqtq
      421 qqvaqpspvs hqqqpqqspl ppgikptiqi kqesgvkiit qqvqpskilp kpvtatlpts
      481 snspimvvss ngaimttklv ttptgtqaty trptvspsig rmaatpgaat yvkttsgsii
      541 tvvpkslatl ggkiissniv sgtttkitti pmtskpnviv vqkttgkgtt iqglpgknvv
      601 ttllnaggek tiqtvptgak pailtatrpi tkmivtqpkg igstvqpaak iiptkivygq
      661 qgktqvlikp kpvtfqatvv seqtrqlvte tlqqasrvae agnssiqegk eepqnytdss
      721 ssstessqss qdsqpvvhvi asrrqdwseh eiametspti iyqdvssesq satstikall
      781 elqqttvkek leskprqpti dlsqmavpiq mtqekrhspe spsiavvese lvaeyitter
      841 tdegtevafp llvshrsqpq qpsqpqrtll qhvaqsqtat qtsvvvksip asspgaithi
      901 mqqalsshta ftkhseelgt eegeveemdt ldpqtglfyr saltqsqsak qqklsqpple
      961 qtqlqvktlq cfqtkqkqti hlqadqlqhk lpqmpqlsir hqkltplqqe qaqpkpdvqh
     1021 tqhpmvakdr qlptlmaqpp qtvvqvlavk ttqqlpklqq apnqpkiyvq pqtpqsqmsl
     1081 passekqtas qveqpiitqg ssvtkitfeg rqpptvtkit ggssvpklts pvtsispiqa
     1141 sektavsdil kmslmeaqid tnvehmivdp pkkalatsml tgeagslpst hmvvagmans
     1201 tpqqqkcres csspstvgss lttrkidppa vpatgqfmri qnvgqkkaee spaeiiiqvk
     1261 tkellspgyp levvfylpls lqgyssvcys lslqlqcggg aqwas
//
LOCUS       XP_054225370            1292 aa            linear   PRI 05-AUG-2025
DEFINITION  BRCA2-interacting transcriptional repressor EMSY isoform X9 [Homo
            sapiens].
ACCESSION   XP_054225370
VERSION     XP_054225370.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369395.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1292
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1292
                     /product="BRCA2-interacting transcriptional repressor EMSY
                     isoform X9"
                     /calculated_mol_wt=138089
     Region          17..86
                     /region_name="ENT"
                     /note="ENT domain; pfam03735"
                     /db_xref="CDD:461032"
     Region          <470..571
                     /region_name="COG3889"
                     /note="Extracellular solute-binding protein, contains
                     Ig-fold domain [General function prediction only]"
                     /db_xref="CDD:443097"
     Region          <937..1108
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     CDS             1..1292
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /coded_by="XM_054369395.1:151..4029"
                     /db_xref="GeneID:56946"
                     /db_xref="HGNC:HGNC:18071"
                     /db_xref="MIM:608574"
ORIGIN      
        1 mpvvwptlld lsrdeckril rkleleayag visalraqgd ltkekkdllg elskvlsist
       61 erhraevrra vnderlttia hnmsgpnsss ewsiegrrlv plmprlvpqt aftvtanava
      121 naaiqhnasl pvpaetgske vvvcysytst tstptstpvp sgsiatvksp rpaspasnvv
      181 vlpsgstvyv ksvscsdede kprkrrrtns sssspvvlke vpkavvpvsk titvpvsgsp
      241 kmsnimqsia nslpphmspv kitftkpstq ttntttqkvi ivttspsstf vpnilskshn
      301 yaavtklvpt sviasttqkp pvvitasqss lvsnsssgss sstpspipnt vavtavvsst
      361 psvvmstvaq gvstsaikma strlpspksl vsaptqilaq fpkqhqqspk qqlyqvqqqt
      421 qqqvaqpspv shqqqpqqsp lppgikptiq ikqesgvkii tqqvqpskil pkpvtatlpt
      481 ssnspimvvs sngaimttkl vttptgtqat ytrptvspsi grmaatpgaa tyvkttsgsi
      541 itvvpkslat lggkiissni vsgtttkitt ipmtskpnvi vvqkttgkgt tiqglpgknv
      601 vttllnagge ktiqtvptga kpailtatrp itkmivtqpk gigstvqpaa kiiptkivyg
      661 qqgktqvlik pkpvtfqatv vseqtrqlvt etlqqasrva eagnssiqeg keepqnytds
      721 sssstessqs sqdsqpvvhv iasrrqdwse heiametspt iiyqdvsses qsatstikal
      781 lelqqttvke kleskprqpt idlsqmavpi qmtqekrhsp espsiavves elvaeyittv
      841 shrsqpqqps qpqrtllqhv aqsqtatqts vvvksipass pgaithimqq alsshtaftk
      901 hseelgteeg eveemdtldp qtglfyrsal tqsqsakqqk lsqppleqtq lqvktlqcfq
      961 tkqkqtihlq adqlqhklpq mpqlsirhqk ltplqqeqaq pkpdvqhtqh pmvakdrqlp
     1021 tlmaqppqtv vqvlavkttq qlpklqqapn qpkiyvqpqt pqsqmslpas sekqtasqve
     1081 qpiitqgssv tkitfegrqp ptvtkitggs svpkltspvt sispiqasek tavsdilkms
     1141 lmeaqidtnv ehmivdppkk alatsmltge agslpsthmv vagmanstpq qqkcrescss
     1201 pstvgssltt rkidppavpa tgqfmriqnv gqkkaeespa eiiiqvktke llspgyplev
     1261 vfylplslqg yssvcyslsl qlqcgggaqw as
//
LOCUS       XP_054225371            1286 aa            linear   PRI 05-AUG-2025
DEFINITION  BRCA2-interacting transcriptional repressor EMSY isoform X10 [Homo
            sapiens].
ACCESSION   XP_054225371
VERSION     XP_054225371.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369396.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1286
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1286
                     /product="BRCA2-interacting transcriptional repressor EMSY
                     isoform X10"
                     /calculated_mol_wt=137921
     Region          17..81
                     /region_name="ENT"
                     /note="ENT domain; pfam03735"
                     /db_xref="CDD:461032"
     Region          <433..534
                     /region_name="COG3889"
                     /note="Extracellular solute-binding protein, contains
                     Ig-fold domain [General function prediction only]"
                     /db_xref="CDD:443097"
     Region          <914..1085
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     CDS             1..1286
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /coded_by="XM_054369396.1:151..4011"
                     /db_xref="GeneID:56946"
                     /db_xref="HGNC:HGNC:18071"
                     /db_xref="MIM:608574"
ORIGIN      
        1 mpvvwptlld lsrdeckril rkleleayag visalraqgd ltkekkdllg elskvlsist
       61 erhraevrra vnderlttia hkmnlslylg erpsysmsgp nsssewsieg rrlvplmprl
      121 vpqtaftvta navanaaiqh naslpvpaet gskegvscsd edekprkrrr tnssssspvv
      181 lkevpkavvp vsktitvpvs gspkmsnimq sianslpphm spvkitftkp stqttntttq
      241 kviivttsps stfvpnilsk shnyaavtkl vptsviastt qkppvvitas qsslvsnsss
      301 gsssstpspi pntvavtavv sstpsvvmst vaqgvstsai kmastrlpsp kslvsaptqi
      361 laqfpkqhqq spkqqlyqvq qqtqqqvaqp spvshqqqpq qsplppgikp tiqikqesgv
      421 kiitqqvqps kilpkpvtat lptssnspim vvssngaimt tklvttptgt qatytrptvs
      481 psigrmaatp gaatyvktts gsiitvvpks latlggkiis snivsgtttk ittipmtskp
      541 nvivvqkttg kgttiqglpg knvvttllna ggektiqtvp tgakpailta trpitkmivt
      601 qpkgigstvq paakiiptki vygqqgktqv likpkpvtfq atvvseqtrq lvtetlqqas
      661 rvaeagnssi qegkeepqny tdssssstes sqssqdsqpv vhviasrrqd wseheiamet
      721 sptiiyqdvs sesqsatsti kallelqqtt vkekleskpr qptidlsqma vpiqmtqekr
      781 hspespsiav veselvaeyi ttertdegte vafpllvshr sqpqqpsqpq rtllqhvaqs
      841 qtatqtsvvv ksipasspga ithimqqals shtaftkhse elgteegeve emdtldpqtg
      901 lfyrsaltqs qsakqqklsq ppleqtqlqv ktlqcfqtkq kqtihlqadq lqhklpqmpq
      961 lsirhqkltp lqqeqaqpkp dvqhtqhpmv akdrqlptlm aqppqtvvqv lavkttqqlp
     1021 klqqapnqpk iyvqpqtpqs qmslpassek qtasqveqpi itqgssvtki tfegrqpptv
     1081 tkitggssvp kltspvtsis piqasektav sdilkmslme aqidtnvehm ivdppkkala
     1141 tsmltgeags lpsthmvvag manstpqqqk crescsspst vgsslttrki dppavpatgq
     1201 fmriqnvgqk kaeespaeii iqaipqyaip chsssnvvve psgllelnnf tsqqlddeet
     1261 ameqdidsst edgtepspsq ssaers
//
LOCUS       XP_054225372            1282 aa            linear   PRI 05-AUG-2025
DEFINITION  BRCA2-interacting transcriptional repressor EMSY isoform X11 [Homo
            sapiens].
ACCESSION   XP_054225372
VERSION     XP_054225372.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369397.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1282
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1282
                     /product="BRCA2-interacting transcriptional repressor EMSY
                     isoform X11"
                     /calculated_mol_wt=136936
     Region          17..81
                     /region_name="ENT"
                     /note="ENT domain; pfam03735"
                     /db_xref="CDD:461032"
     Region          <484..585
                     /region_name="COG3889"
                     /note="Extracellular solute-binding protein, contains
                     Ig-fold domain [General function prediction only]"
                     /db_xref="CDD:443097"
     Region          <910..1081
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     CDS             1..1282
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /coded_by="XM_054369397.1:151..3999"
                     /db_xref="GeneID:56946"
                     /db_xref="HGNC:HGNC:18071"
                     /db_xref="MIM:608574"
ORIGIN      
        1 mpvvwptlld lsrdeckril rkleleayag visalraqgd ltkekkdllg elskvlsist
       61 erhraevrra vnderlttia hkmnlslylg erpsysmsgp nsssewsieg rrlvplmprl
      121 vpqtaftvta navanaaiqh naslpvpaet gskevvvcys ytsttstpts tpvpsgsiat
      181 vksprpaspa snvvvlpsgs tvyvksvscs dedekprkrr rtnssssspv vlkevpkavv
      241 pvsktitvpv sgspkmsnim qsianslpph mspvkitftk pstqttnttt qkviivttsp
      301 sstfvpnils kshnyaavtk lvptsviast tqkppvvita sqsslvsnss sgsssstpsp
      361 ipntvavtav vsstpsvvms tvaqgvstsa ikmastrlps pkslvsaptq ilaqfpkqhq
      421 qspkqqlyqv qqqtqqqvaq pspvshqqqp qqsplppgik ptiqikqesg vkiitqqvqp
      481 skilpkpvta tlptssnspi mvvssngaim ttklvttptg tqatytrptv spsigrmaat
      541 pgaatyvktt sgsiitvvpk slatlggkii ssnivsgttt kittipmtsk pnvivvqktt
      601 gkgttiqglp gknvvttlln aggektiqtv ptgakpailt atrpitkmiv tqpkgigstv
      661 qpaakiiptk ivygqqgktq vlikpkpvtf qatvvseqtr qlvtetlqqa srvaeagnss
      721 iqegkeepqn ytdssssste ssqssqvkek leskprqpti dlsqmavpiq mtqekrhspe
      781 spsiavvese lvaeyitter tdegtevafp llvshrsqpq qpsqpqrtll qhvaqsqtat
      841 qtsvvvksip asspgaithi mqqalsshta ftkhseelgt eegeveemdt ldpqtglfyr
      901 saltqsqsak qqklsqpple qtqlqvktlq cfqtkqkqti hlqadqlqhk lpqmpqlsir
      961 hqkltplqqe qaqpkpdvqh tqhpmvakdr qlptlmaqpp qtvvqvlavk ttqqlpklqq
     1021 apnqpkiyvq pqtpqsqmsl passekqtas qveqpiitqg ssvtkitfeg rqpptvtkit
     1081 ggssvpklts pvtsispiqa sektavsdil kmslmeaqid tnvehmivdp pkkalatsml
     1141 tgeagslpst hmvvagmans tpqqqkcres csspstvgss lttrkidppa vpatgqfmri
     1201 qnvgqkkaee spaeiiiqai pqyaipchss snvvvepsgl lelnnftsqq lddeetameq
     1261 didsstedgt epspsqssae rs
//
LOCUS       XP_054225373            1281 aa            linear   PRI 05-AUG-2025
DEFINITION  BRCA2-interacting transcriptional repressor EMSY isoform X12 [Homo
            sapiens].
ACCESSION   XP_054225373
VERSION     XP_054225373.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369398.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1281
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1281
                     /product="BRCA2-interacting transcriptional repressor EMSY
                     isoform X12"
                     /calculated_mol_wt=136837
     Region          17..81
                     /region_name="ENT"
                     /note="ENT domain; pfam03735"
                     /db_xref="CDD:461032"
     Region          <483..584
                     /region_name="COG3889"
                     /note="Extracellular solute-binding protein, contains
                     Ig-fold domain [General function prediction only]"
                     /db_xref="CDD:443097"
     Region          <909..1080
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     CDS             1..1281
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /coded_by="XM_054369398.1:151..3996"
                     /db_xref="GeneID:56946"
                     /db_xref="HGNC:HGNC:18071"
                     /db_xref="MIM:608574"
ORIGIN      
        1 mpvvwptlld lsrdeckril rkleleayag visalraqgd ltkekkdllg elskvlsist
       61 erhraevrra vnderlttia hkmnlslylg erpsysmsgp nsssewsieg rrlvplmprl
      121 vpqtaftvta navanaaiqh naslpvpaet gskevvcysy tsttstptst pvpsgsiatv
      181 ksprpaspas nvvvlpsgst vyvksvscsd edekprkrrr tnssssspvv lkevpkavvp
      241 vsktitvpvs gspkmsnimq sianslpphm spvkitftkp stqttntttq kviivttsps
      301 stfvpnilsk shnyaavtkl vptsviastt qkppvvitas qsslvsnsss gsssstpspi
      361 pntvavtavv sstpsvvmst vaqgvstsai kmastrlpsp kslvsaptqi laqfpkqhqq
      421 spkqqlyqvq qqtqqqvaqp spvshqqqpq qsplppgikp tiqikqesgv kiitqqvqps
      481 kilpkpvtat lptssnspim vvssngaimt tklvttptgt qatytrptvs psigrmaatp
      541 gaatyvktts gsiitvvpks latlggkiis snivsgtttk ittipmtskp nvivvqkttg
      601 kgttiqglpg knvvttllna ggektiqtvp tgakpailta trpitkmivt qpkgigstvq
      661 paakiiptki vygqqgktqv likpkpvtfq atvvseqtrq lvtetlqqas rvaeagnssi
      721 qegkeepqny tdssssstes sqssqvkekl eskprqptid lsqmavpiqm tqekrhspes
      781 psiavvesel vaeyittert degtevafpl lvshrsqpqq psqpqrtllq hvaqsqtatq
      841 tsvvvksipa sspgaithim qqalsshtaf tkhseelgte egeveemdtl dpqtglfyrs
      901 altqsqsakq qklsqppleq tqlqvktlqc fqtkqkqtih lqadqlqhkl pqmpqlsirh
      961 qkltplqqeq aqpkpdvqht qhpmvakdrq lptlmaqppq tvvqvlavkt tqqlpklqqa
     1021 pnqpkiyvqp qtpqsqmslp assekqtasq veqpiitqgs svtkitfegr qpptvtkitg
     1081 gssvpkltsp vtsispiqas ektavsdilk mslmeaqidt nvehmivdpp kkalatsmlt
     1141 geagslpsth mvvagmanst pqqqkcresc sspstvgssl ttrkidppav patgqfmriq
     1201 nvgqkkaees paeiiiqaip qyaipchsss nvvvepsgll elnnftsqql ddeetameqd
     1261 idsstedgte pspsqssaer s
//
LOCUS       XP_054225374            1272 aa            linear   PRI 05-AUG-2025
DEFINITION  BRCA2-interacting transcriptional repressor EMSY isoform X13 [Homo
            sapiens].
ACCESSION   XP_054225374
VERSION     XP_054225374.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369399.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1272
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1272
                     /product="BRCA2-interacting transcriptional repressor EMSY
                     isoform X13"
                     /calculated_mol_wt=136295
     Region          17..86
                     /region_name="ENT"
                     /note="ENT domain; pfam03735"
                     /db_xref="CDD:461032"
     Region          <419..520
                     /region_name="COG3889"
                     /note="Extracellular solute-binding protein, contains
                     Ig-fold domain [General function prediction only]"
                     /db_xref="CDD:443097"
     Region          <900..1071
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     CDS             1..1272
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /coded_by="XM_054369399.1:151..3969"
                     /db_xref="GeneID:56946"
                     /db_xref="HGNC:HGNC:18071"
                     /db_xref="MIM:608574"
ORIGIN      
        1 mpvvwptlld lsrdeckril rkleleayag visalraqgd ltkekkdllg elskvlsist
       61 erhraevrra vnderlttia hnmsgpnsss ewsiegrrlv plmprlvpqt aftvtanava
      121 naaiqhnasl pvpaetgske gvscsdedek prkrrrtnss ssspvvlkev pkavvpvskt
      181 itvpvsgspk msnimqsian slpphmspvk itftkpstqt tntttqkvii vttspsstfv
      241 pnilskshny aavtklvpts viasttqkpp vvitasqssl vsnsssgsss stpspipntv
      301 avtavvsstp svvmstvaqg vstsaikmas trlpspkslv saptqilaqf pkqhqqspkq
      361 qlyqvqqqtq qqvaqpspvs hqqqpqqspl ppgikptiqi kqesgvkiit qqvqpskilp
      421 kpvtatlpts snspimvvss ngaimttklv ttptgtqaty trptvspsig rmaatpgaat
      481 yvkttsgsii tvvpkslatl ggkiissniv sgtttkitti pmtskpnviv vqkttgkgtt
      541 iqglpgknvv ttllnaggek tiqtvptgak pailtatrpi tkmivtqpkg igstvqpaak
      601 iiptkivygq qgktqvlikp kpvtfqatvv seqtrqlvte tlqqasrvae agnssiqegk
      661 eepqnytdss ssstessqss qdsqpvvhvi asrrqdwseh eiametspti iyqdvssesq
      721 satstikall elqqttvkek leskprqpti dlsqmavpiq mtqekrhspe spsiavvese
      781 lvaeyitter tdegtevafp llvshrsqpq qpsqpqrtll qhvaqsqtat qtsvvvksip
      841 asspgaithi mqqalsshta ftkhseelgt eegeveemdt ldpqtglfyr saltqsqsak
      901 qqklsqpple qtqlqvktlq cfqtkqkqti hlqadqlqhk lpqmpqlsir hqkltplqqe
      961 qaqpkpdvqh tqhpmvakdr qlptlmaqpp qtvvqvlavk ttqqlpklqq apnqpkiyvq
     1021 pqtpqsqmsl passekqtas qveqpiitqg ssvtkitfeg rqpptvtkit ggssvpklts
     1081 pvtsispiqa sektavsdil kmslmeaqid tnvehmivdp pkkalatsml tgeagslpst
     1141 hmvvagmans tpqqqkcres csspstvgss lttrkidppa vpatgqfmri qnvgqkkaee
     1201 spaeiiiqai pqyaipchss snvvvepsgl lelnnftsqq lddeetameq didsstedgt
     1261 epspsqssae rs
//
LOCUS       XP_054225375            1272 aa            linear   PRI 05-AUG-2025
DEFINITION  BRCA2-interacting transcriptional repressor EMSY isoform X14 [Homo
            sapiens].
ACCESSION   XP_054225375
VERSION     XP_054225375.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369400.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1272
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1272
                     /product="BRCA2-interacting transcriptional repressor EMSY
                     isoform X14"
                     /calculated_mol_wt=136363
     Region          17..81
                     /region_name="ENT"
                     /note="ENT domain; pfam03735"
                     /db_xref="CDD:461032"
     Region          <433..534
                     /region_name="COG3889"
                     /note="Extracellular solute-binding protein, contains
                     Ig-fold domain [General function prediction only]"
                     /db_xref="CDD:443097"
     Region          <900..1071
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     CDS             1..1272
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /coded_by="XM_054369400.1:151..3969"
                     /db_xref="GeneID:56946"
                     /db_xref="HGNC:HGNC:18071"
                     /db_xref="MIM:608574"
ORIGIN      
        1 mpvvwptlld lsrdeckril rkleleayag visalraqgd ltkekkdllg elskvlsist
       61 erhraevrra vnderlttia hkmnlslylg erpsysmsgp nsssewsieg rrlvplmprl
      121 vpqtaftvta navanaaiqh naslpvpaet gskegvscsd edekprkrrr tnssssspvv
      181 lkevpkavvp vsktitvpvs gspkmsnimq sianslpphm spvkitftkp stqttntttq
      241 kviivttsps stfvpnilsk shnyaavtkl vptsviastt qkppvvitas qsslvsnsss
      301 gsssstpspi pntvavtavv sstpsvvmst vaqgvstsai kmastrlpsp kslvsaptqi
      361 laqfpkqhqq spkqqlyqvq qqtqqqvaqp spvshqqqpq qsplppgikp tiqikqesgv
      421 kiitqqvqps kilpkpvtat lptssnspim vvssngaimt tklvttptgt qatytrptvs
      481 psigrmaatp gaatyvktts gsiitvvpks latlggkiis snivsgtttk ittipmtskp
      541 nvivvqkttg kgttiqglpg knvvttllna ggektiqtvp tgakpailta trpitkmivt
      601 qpkgigstvq paakiiptki vygqqgktqv likpkpvtfq atvvseqtrq lvtetlqqas
      661 rvaeagnssi qegkeepqny tdssssstes sqssqdsqpv vhviasrrqd wseheiamet
      721 sptiiyqdvs sesqsatsti kallelqqtt vkekleskpr qptidlsqma vpiqmtqekr
      781 hspespsiav veselvaeyi ttvshrsqpq qpsqpqrtll qhvaqsqtat qtsvvvksip
      841 asspgaithi mqqalsshta ftkhseelgt eegeveemdt ldpqtglfyr saltqsqsak
      901 qqklsqpple qtqlqvktlq cfqtkqkqti hlqadqlqhk lpqmpqlsir hqkltplqqe
      961 qaqpkpdvqh tqhpmvakdr qlptlmaqpp qtvvqvlavk ttqqlpklqq apnqpkiyvq
     1021 pqtpqsqmsl passekqtas qveqpiitqg ssvtkitfeg rqpptvtkit ggssvpklts
     1081 pvtsispiqa sektavsdil kmslmeaqid tnvehmivdp pkkalatsml tgeagslpst
     1141 hmvvagmans tpqqqkcres csspstvgss lttrkidppa vpatgqfmri qnvgqkkaee
     1201 spaeiiiqai pqyaipchss snvvvepsgl lelnnftsqq lddeetameq didsstedgt
     1261 epspsqssae rs
//
LOCUS       XP_054225376            1269 aa            linear   PRI 05-AUG-2025
DEFINITION  BRCA2-interacting transcriptional repressor EMSY isoform X15 [Homo
            sapiens].
ACCESSION   XP_054225376
VERSION     XP_054225376.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369401.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1269
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1269
                     /product="BRCA2-interacting transcriptional repressor EMSY
                     isoform X15"
                     /calculated_mol_wt=136133
     Region          17..81
                     /region_name="ENT"
                     /note="ENT domain; pfam03735"
                     /db_xref="CDD:461032"
     Region          <433..534
                     /region_name="COG3889"
                     /note="Extracellular solute-binding protein, contains
                     Ig-fold domain [General function prediction only]"
                     /db_xref="CDD:443097"
     Region          <914..1085
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     CDS             1..1269
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /coded_by="XM_054369401.1:151..3960"
                     /db_xref="GeneID:56946"
                     /db_xref="HGNC:HGNC:18071"
                     /db_xref="MIM:608574"
ORIGIN      
        1 mpvvwptlld lsrdeckril rkleleayag visalraqgd ltkekkdllg elskvlsist
       61 erhraevrra vnderlttia hkmnlslylg erpsysmsgp nsssewsieg rrlvplmprl
      121 vpqtaftvta navanaaiqh naslpvpaet gskegvscsd edekprkrrr tnssssspvv
      181 lkevpkavvp vsktitvpvs gspkmsnimq sianslpphm spvkitftkp stqttntttq
      241 kviivttsps stfvpnilsk shnyaavtkl vptsviastt qkppvvitas qsslvsnsss
      301 gsssstpspi pntvavtavv sstpsvvmst vaqgvstsai kmastrlpsp kslvsaptqi
      361 laqfpkqhqq spkqqlyqvq qqtqqqvaqp spvshqqqpq qsplppgikp tiqikqesgv
      421 kiitqqvqps kilpkpvtat lptssnspim vvssngaimt tklvttptgt qatytrptvs
      481 psigrmaatp gaatyvktts gsiitvvpks latlggkiis snivsgtttk ittipmtskp
      541 nvivvqkttg kgttiqglpg knvvttllna ggektiqtvp tgakpailta trpitkmivt
      601 qpkgigstvq paakiiptki vygqqgktqv likpkpvtfq atvvseqtrq lvtetlqqas
      661 rvaeagnssi qegkeepqny tdssssstes sqssqdsqpv vhviasrrqd wseheiamet
      721 sptiiyqdvs sesqsatsti kallelqqtt vkekleskpr qptidlsqma vpiqmtqekr
      781 hspespsiav veselvaeyi ttertdegte vafpllvshr sqpqqpsqpq rtllqhvaqs
      841 qtatqtsvvv ksipasspga ithimqqals shtaftkhse elgteegeve emdtldpqtg
      901 lfyrsaltqs qsakqqklsq ppleqtqlqv ktlqcfqtkq kqtihlqadq lqhklpqmpq
      961 lsirhqkltp lqqeqaqpkp dvqhtqhpmv akdrqlptlm aqppqtvvqv lavkttqqlp
     1021 klqqapnqpk iyvqpqtpqs qmslpassek qtasqveqpi itqgssvtki tfegrqpptv
     1081 tkitggssvp kltspvtsis piqasektav sdilkmslme aqidtnvehm ivdppkkala
     1141 tsmltgeags lpsthmvvag manstpqqqk crescsspst vgsslttrki dppavpatgq
     1201 fmriqnvgqk kaeespaeii iqvktkells pgyplevvfy lplslqgyss vcyslslqlq
     1261 cgggaqwas
//
LOCUS       XP_054225377            1268 aa            linear   PRI 05-AUG-2025
DEFINITION  BRCA2-interacting transcriptional repressor EMSY isoform X16 [Homo
            sapiens].
ACCESSION   XP_054225377
VERSION     XP_054225377.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369402.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1268
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1268
                     /product="BRCA2-interacting transcriptional repressor EMSY
                     isoform X16"
                     /calculated_mol_wt=135311
     Region          17..86
                     /region_name="ENT"
                     /note="ENT domain; pfam03735"
                     /db_xref="CDD:461032"
     Region          <470..571
                     /region_name="COG3889"
                     /note="Extracellular solute-binding protein, contains
                     Ig-fold domain [General function prediction only]"
                     /db_xref="CDD:443097"
     Region          <896..1067
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     CDS             1..1268
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /coded_by="XM_054369402.1:151..3957"
                     /db_xref="GeneID:56946"
                     /db_xref="HGNC:HGNC:18071"
                     /db_xref="MIM:608574"
ORIGIN      
        1 mpvvwptlld lsrdeckril rkleleayag visalraqgd ltkekkdllg elskvlsist
       61 erhraevrra vnderlttia hnmsgpnsss ewsiegrrlv plmprlvpqt aftvtanava
      121 naaiqhnasl pvpaetgske vvvcysytst tstptstpvp sgsiatvksp rpaspasnvv
      181 vlpsgstvyv ksvscsdede kprkrrrtns sssspvvlke vpkavvpvsk titvpvsgsp
      241 kmsnimqsia nslpphmspv kitftkpstq ttntttqkvi ivttspsstf vpnilskshn
      301 yaavtklvpt sviasttqkp pvvitasqss lvsnsssgss sstpspipnt vavtavvsst
      361 psvvmstvaq gvstsaikma strlpspksl vsaptqilaq fpkqhqqspk qqlyqvqqqt
      421 qqqvaqpspv shqqqpqqsp lppgikptiq ikqesgvkii tqqvqpskil pkpvtatlpt
      481 ssnspimvvs sngaimttkl vttptgtqat ytrptvspsi grmaatpgaa tyvkttsgsi
      541 itvvpkslat lggkiissni vsgtttkitt ipmtskpnvi vvqkttgkgt tiqglpgknv
      601 vttllnagge ktiqtvptga kpailtatrp itkmivtqpk gigstvqpaa kiiptkivyg
      661 qqgktqvlik pkpvtfqatv vseqtrqlvt etlqqasrva eagnssiqeg keepqnytds
      721 sssstessqs sqvkeklesk prqptidlsq mavpiqmtqe krhspespsi avveselvae
      781 yittertdeg tevafpllvs hrsqpqqpsq pqrtllqhva qsqtatqtsv vvksipassp
      841 gaithimqqa lsshtaftkh seelgteege veemdtldpq tglfyrsalt qsqsakqqkl
      901 sqppleqtql qvktlqcfqt kqkqtihlqa dqlqhklpqm pqlsirhqkl tplqqeqaqp
      961 kpdvqhtqhp mvakdrqlpt lmaqppqtvv qvlavkttqq lpklqqapnq pkiyvqpqtp
     1021 qsqmslpass ekqtasqveq piitqgssvt kitfegrqpp tvtkitggss vpkltspvts
     1081 ispiqasekt avsdilkmsl meaqidtnve hmivdppkka latsmltgea gslpsthmvv
     1141 agmanstpqq qkcrescssp stvgsslttr kidppavpat gqfmriqnvg qkkaeespae
     1201 iiiqaipqya ipchsssnvv vepsglleln nftsqqldde etameqdids stedgtepsp
     1261 sqssaers
//
LOCUS       XP_054225378            1268 aa            linear   PRI 05-AUG-2025
DEFINITION  BRCA2-interacting transcriptional repressor EMSY isoform X17 [Homo
            sapiens].
ACCESSION   XP_054225378
VERSION     XP_054225378.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369403.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1268
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1268
                     /product="BRCA2-interacting transcriptional repressor EMSY
                     isoform X17"
                     /calculated_mol_wt=135378
     Region          17..81
                     /region_name="ENT"
                     /note="ENT domain; pfam03735"
                     /db_xref="CDD:461032"
     Region          <484..585
                     /region_name="COG3889"
                     /note="Extracellular solute-binding protein, contains
                     Ig-fold domain [General function prediction only]"
                     /db_xref="CDD:443097"
     Region          <896..1067
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     CDS             1..1268
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /coded_by="XM_054369403.1:151..3957"
                     /db_xref="GeneID:56946"
                     /db_xref="HGNC:HGNC:18071"
                     /db_xref="MIM:608574"
ORIGIN      
        1 mpvvwptlld lsrdeckril rkleleayag visalraqgd ltkekkdllg elskvlsist
       61 erhraevrra vnderlttia hkmnlslylg erpsysmsgp nsssewsieg rrlvplmprl
      121 vpqtaftvta navanaaiqh naslpvpaet gskevvvcys ytsttstpts tpvpsgsiat
      181 vksprpaspa snvvvlpsgs tvyvksvscs dedekprkrr rtnssssspv vlkevpkavv
      241 pvsktitvpv sgspkmsnim qsianslpph mspvkitftk pstqttnttt qkviivttsp
      301 sstfvpnils kshnyaavtk lvptsviast tqkppvvita sqsslvsnss sgsssstpsp
      361 ipntvavtav vsstpsvvms tvaqgvstsa ikmastrlps pkslvsaptq ilaqfpkqhq
      421 qspkqqlyqv qqqtqqqvaq pspvshqqqp qqsplppgik ptiqikqesg vkiitqqvqp
      481 skilpkpvta tlptssnspi mvvssngaim ttklvttptg tqatytrptv spsigrmaat
      541 pgaatyvktt sgsiitvvpk slatlggkii ssnivsgttt kittipmtsk pnvivvqktt
      601 gkgttiqglp gknvvttlln aggektiqtv ptgakpailt atrpitkmiv tqpkgigstv
      661 qpaakiiptk ivygqqgktq vlikpkpvtf qatvvseqtr qlvtetlqqa srvaeagnss
      721 iqegkeepqn ytdssssste ssqssqvkek leskprqpti dlsqmavpiq mtqekrhspe
      781 spsiavvese lvaeyittvs hrsqpqqpsq pqrtllqhva qsqtatqtsv vvksipassp
      841 gaithimqqa lsshtaftkh seelgteege veemdtldpq tglfyrsalt qsqsakqqkl
      901 sqppleqtql qvktlqcfqt kqkqtihlqa dqlqhklpqm pqlsirhqkl tplqqeqaqp
      961 kpdvqhtqhp mvakdrqlpt lmaqppqtvv qvlavkttqq lpklqqapnq pkiyvqpqtp
     1021 qsqmslpass ekqtasqveq piitqgssvt kitfegrqpp tvtkitggss vpkltspvts
     1081 ispiqasekt avsdilkmsl meaqidtnve hmivdppkka latsmltgea gslpsthmvv
     1141 agmanstpqq qkcrescssp stvgsslttr kidppavpat gqfmriqnvg qkkaeespae
     1201 iiiqaipqya ipchsssnvv vepsglleln nftsqqldde etameqdids stedgtepsp
     1261 sqssaers
//
LOCUS       XP_054225379            1267 aa            linear   PRI 05-AUG-2025
DEFINITION  BRCA2-interacting transcriptional repressor EMSY isoform X18 [Homo
            sapiens].
ACCESSION   XP_054225379
VERSION     XP_054225379.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369404.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1267
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1267
                     /product="BRCA2-interacting transcriptional repressor EMSY
                     isoform X18"
                     /calculated_mol_wt=135211
     Region          17..86
                     /region_name="ENT"
                     /note="ENT domain; pfam03735"
                     /db_xref="CDD:461032"
     Region          <469..570
                     /region_name="COG3889"
                     /note="Extracellular solute-binding protein, contains
                     Ig-fold domain [General function prediction only]"
                     /db_xref="CDD:443097"
     Region          <895..1066
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     CDS             1..1267
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /coded_by="XM_054369404.1:151..3954"
                     /db_xref="GeneID:56946"
                     /db_xref="HGNC:HGNC:18071"
                     /db_xref="MIM:608574"
ORIGIN      
        1 mpvvwptlld lsrdeckril rkleleayag visalraqgd ltkekkdllg elskvlsist
       61 erhraevrra vnderlttia hnmsgpnsss ewsiegrrlv plmprlvpqt aftvtanava
      121 naaiqhnasl pvpaetgske vvcysytstt stptstpvps gsiatvkspr paspasnvvv
      181 lpsgstvyvk svscsdedek prkrrrtnss ssspvvlkev pkavvpvskt itvpvsgspk
      241 msnimqsian slpphmspvk itftkpstqt tntttqkvii vttspsstfv pnilskshny
      301 aavtklvpts viasttqkpp vvitasqssl vsnsssgsss stpspipntv avtavvsstp
      361 svvmstvaqg vstsaikmas trlpspkslv saptqilaqf pkqhqqspkq qlyqvqqqtq
      421 qqvaqpspvs hqqqpqqspl ppgikptiqi kqesgvkiit qqvqpskilp kpvtatlpts
      481 snspimvvss ngaimttklv ttptgtqaty trptvspsig rmaatpgaat yvkttsgsii
      541 tvvpkslatl ggkiissniv sgtttkitti pmtskpnviv vqkttgkgtt iqglpgknvv
      601 ttllnaggek tiqtvptgak pailtatrpi tkmivtqpkg igstvqpaak iiptkivygq
      661 qgktqvlikp kpvtfqatvv seqtrqlvte tlqqasrvae agnssiqegk eepqnytdss
      721 ssstessqss qvkekleskp rqptidlsqm avpiqmtqek rhspespsia vveselvaey
      781 ittertdegt evafpllvsh rsqpqqpsqp qrtllqhvaq sqtatqtsvv vksipasspg
      841 aithimqqal sshtaftkhs eelgteegev eemdtldpqt glfyrsaltq sqsakqqkls
      901 qppleqtqlq vktlqcfqtk qkqtihlqad qlqhklpqmp qlsirhqklt plqqeqaqpk
      961 pdvqhtqhpm vakdrqlptl maqppqtvvq vlavkttqql pklqqapnqp kiyvqpqtpq
     1021 sqmslpasse kqtasqveqp iitqgssvtk itfegrqppt vtkitggssv pkltspvtsi
     1081 spiqasekta vsdilkmslm eaqidtnveh mivdppkkal atsmltgeag slpsthmvva
     1141 gmanstpqqq kcrescssps tvgsslttrk idppavpatg qfmriqnvgq kkaeespaei
     1201 iiqaipqyai pchsssnvvv epsgllelnn ftsqqlddee tameqdidss tedgtepsps
     1261 qssaers
//
LOCUS       XP_054225380            1267 aa            linear   PRI 05-AUG-2025
DEFINITION  BRCA2-interacting transcriptional repressor EMSY isoform X19 [Homo
            sapiens].
ACCESSION   XP_054225380
VERSION     XP_054225380.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369405.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1267
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1267
                     /product="BRCA2-interacting transcriptional repressor EMSY
                     isoform X19"
                     /calculated_mol_wt=135279
     Region          17..81
                     /region_name="ENT"
                     /note="ENT domain; pfam03735"
                     /db_xref="CDD:461032"
     Region          <483..584
                     /region_name="COG3889"
                     /note="Extracellular solute-binding protein, contains
                     Ig-fold domain [General function prediction only]"
                     /db_xref="CDD:443097"
     Region          <895..1066
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     CDS             1..1267
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /coded_by="XM_054369405.1:151..3954"
                     /db_xref="GeneID:56946"
                     /db_xref="HGNC:HGNC:18071"
                     /db_xref="MIM:608574"
ORIGIN      
        1 mpvvwptlld lsrdeckril rkleleayag visalraqgd ltkekkdllg elskvlsist
       61 erhraevrra vnderlttia hkmnlslylg erpsysmsgp nsssewsieg rrlvplmprl
      121 vpqtaftvta navanaaiqh naslpvpaet gskevvcysy tsttstptst pvpsgsiatv
      181 ksprpaspas nvvvlpsgst vyvksvscsd edekprkrrr tnssssspvv lkevpkavvp
      241 vsktitvpvs gspkmsnimq sianslpphm spvkitftkp stqttntttq kviivttsps
      301 stfvpnilsk shnyaavtkl vptsviastt qkppvvitas qsslvsnsss gsssstpspi
      361 pntvavtavv sstpsvvmst vaqgvstsai kmastrlpsp kslvsaptqi laqfpkqhqq
      421 spkqqlyqvq qqtqqqvaqp spvshqqqpq qsplppgikp tiqikqesgv kiitqqvqps
      481 kilpkpvtat lptssnspim vvssngaimt tklvttptgt qatytrptvs psigrmaatp
      541 gaatyvktts gsiitvvpks latlggkiis snivsgtttk ittipmtskp nvivvqkttg
      601 kgttiqglpg knvvttllna ggektiqtvp tgakpailta trpitkmivt qpkgigstvq
      661 paakiiptki vygqqgktqv likpkpvtfq atvvseqtrq lvtetlqqas rvaeagnssi
      721 qegkeepqny tdssssstes sqssqvkekl eskprqptid lsqmavpiqm tqekrhspes
      781 psiavvesel vaeyittvsh rsqpqqpsqp qrtllqhvaq sqtatqtsvv vksipasspg
      841 aithimqqal sshtaftkhs eelgteegev eemdtldpqt glfyrsaltq sqsakqqkls
      901 qppleqtqlq vktlqcfqtk qkqtihlqad qlqhklpqmp qlsirhqklt plqqeqaqpk
      961 pdvqhtqhpm vakdrqlptl maqppqtvvq vlavkttqql pklqqapnqp kiyvqpqtpq
     1021 sqmslpasse kqtasqveqp iitqgssvtk itfegrqppt vtkitggssv pkltspvtsi
     1081 spiqasekta vsdilkmslm eaqidtnveh mivdppkkal atsmltgeag slpsthmvva
     1141 gmanstpqqq kcrescssps tvgsslttrk idppavpatg qfmriqnvgq kkaeespaei
     1201 iiqaipqyai pchsssnvvv epsgllelnn ftsqqlddee tameqdidss tedgtepsps
     1261 qssaers
//
LOCUS       XP_054225381            1258 aa            linear   PRI 05-AUG-2025
DEFINITION  BRCA2-interacting transcriptional repressor EMSY isoform X20 [Homo
            sapiens].
ACCESSION   XP_054225381
VERSION     XP_054225381.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369406.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1258
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1258
                     /product="BRCA2-interacting transcriptional repressor EMSY
                     isoform X20"
                     /calculated_mol_wt=134737
     Region          17..86
                     /region_name="ENT"
                     /note="ENT domain; pfam03735"
                     /db_xref="CDD:461032"
     Region          <419..520
                     /region_name="COG3889"
                     /note="Extracellular solute-binding protein, contains
                     Ig-fold domain [General function prediction only]"
                     /db_xref="CDD:443097"
     Region          <886..1057
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     CDS             1..1258
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /coded_by="XM_054369406.1:151..3927"
                     /db_xref="GeneID:56946"
                     /db_xref="HGNC:HGNC:18071"
                     /db_xref="MIM:608574"
ORIGIN      
        1 mpvvwptlld lsrdeckril rkleleayag visalraqgd ltkekkdllg elskvlsist
       61 erhraevrra vnderlttia hnmsgpnsss ewsiegrrlv plmprlvpqt aftvtanava
      121 naaiqhnasl pvpaetgske gvscsdedek prkrrrtnss ssspvvlkev pkavvpvskt
      181 itvpvsgspk msnimqsian slpphmspvk itftkpstqt tntttqkvii vttspsstfv
      241 pnilskshny aavtklvpts viasttqkpp vvitasqssl vsnsssgsss stpspipntv
      301 avtavvsstp svvmstvaqg vstsaikmas trlpspkslv saptqilaqf pkqhqqspkq
      361 qlyqvqqqtq qqvaqpspvs hqqqpqqspl ppgikptiqi kqesgvkiit qqvqpskilp
      421 kpvtatlpts snspimvvss ngaimttklv ttptgtqaty trptvspsig rmaatpgaat
      481 yvkttsgsii tvvpkslatl ggkiissniv sgtttkitti pmtskpnviv vqkttgkgtt
      541 iqglpgknvv ttllnaggek tiqtvptgak pailtatrpi tkmivtqpkg igstvqpaak
      601 iiptkivygq qgktqvlikp kpvtfqatvv seqtrqlvte tlqqasrvae agnssiqegk
      661 eepqnytdss ssstessqss qdsqpvvhvi asrrqdwseh eiametspti iyqdvssesq
      721 satstikall elqqttvkek leskprqpti dlsqmavpiq mtqekrhspe spsiavvese
      781 lvaeyittvs hrsqpqqpsq pqrtllqhva qsqtatqtsv vvksipassp gaithimqqa
      841 lsshtaftkh seelgteege veemdtldpq tglfyrsalt qsqsakqqkl sqppleqtql
      901 qvktlqcfqt kqkqtihlqa dqlqhklpqm pqlsirhqkl tplqqeqaqp kpdvqhtqhp
      961 mvakdrqlpt lmaqppqtvv qvlavkttqq lpklqqapnq pkiyvqpqtp qsqmslpass
     1021 ekqtasqveq piitqgssvt kitfegrqpp tvtkitggss vpkltspvts ispiqasekt
     1081 avsdilkmsl meaqidtnve hmivdppkka latsmltgea gslpsthmvv agmanstpqq
     1141 qkcrescssp stvgsslttr kidppavpat gqfmriqnvg qkkaeespae iiiqaipqya
     1201 ipchsssnvv vepsglleln nftsqqldde etameqdids stedgtepsp sqssaers
//
LOCUS       XP_054225382            1255 aa            linear   PRI 05-AUG-2025
DEFINITION  BRCA2-interacting transcriptional repressor EMSY isoform X21 [Homo
            sapiens].
ACCESSION   XP_054225382
VERSION     XP_054225382.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369407.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1255
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1255
                     /product="BRCA2-interacting transcriptional repressor EMSY
                     isoform X21"
                     /calculated_mol_wt=134507
     Region          17..86
                     /region_name="ENT"
                     /note="ENT domain; pfam03735"
                     /db_xref="CDD:461032"
     Region          <419..520
                     /region_name="COG3889"
                     /note="Extracellular solute-binding protein, contains
                     Ig-fold domain [General function prediction only]"
                     /db_xref="CDD:443097"
     Region          <900..1071
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     CDS             1..1255
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /coded_by="XM_054369407.1:151..3918"
                     /db_xref="GeneID:56946"
                     /db_xref="HGNC:HGNC:18071"
                     /db_xref="MIM:608574"
ORIGIN      
        1 mpvvwptlld lsrdeckril rkleleayag visalraqgd ltkekkdllg elskvlsist
       61 erhraevrra vnderlttia hnmsgpnsss ewsiegrrlv plmprlvpqt aftvtanava
      121 naaiqhnasl pvpaetgske gvscsdedek prkrrrtnss ssspvvlkev pkavvpvskt
      181 itvpvsgspk msnimqsian slpphmspvk itftkpstqt tntttqkvii vttspsstfv
      241 pnilskshny aavtklvpts viasttqkpp vvitasqssl vsnsssgsss stpspipntv
      301 avtavvsstp svvmstvaqg vstsaikmas trlpspkslv saptqilaqf pkqhqqspkq
      361 qlyqvqqqtq qqvaqpspvs hqqqpqqspl ppgikptiqi kqesgvkiit qqvqpskilp
      421 kpvtatlpts snspimvvss ngaimttklv ttptgtqaty trptvspsig rmaatpgaat
      481 yvkttsgsii tvvpkslatl ggkiissniv sgtttkitti pmtskpnviv vqkttgkgtt
      541 iqglpgknvv ttllnaggek tiqtvptgak pailtatrpi tkmivtqpkg igstvqpaak
      601 iiptkivygq qgktqvlikp kpvtfqatvv seqtrqlvte tlqqasrvae agnssiqegk
      661 eepqnytdss ssstessqss qdsqpvvhvi asrrqdwseh eiametspti iyqdvssesq
      721 satstikall elqqttvkek leskprqpti dlsqmavpiq mtqekrhspe spsiavvese
      781 lvaeyitter tdegtevafp llvshrsqpq qpsqpqrtll qhvaqsqtat qtsvvvksip
      841 asspgaithi mqqalsshta ftkhseelgt eegeveemdt ldpqtglfyr saltqsqsak
      901 qqklsqpple qtqlqvktlq cfqtkqkqti hlqadqlqhk lpqmpqlsir hqkltplqqe
      961 qaqpkpdvqh tqhpmvakdr qlptlmaqpp qtvvqvlavk ttqqlpklqq apnqpkiyvq
     1021 pqtpqsqmsl passekqtas qveqpiitqg ssvtkitfeg rqpptvtkit ggssvpklts
     1081 pvtsispiqa sektavsdil kmslmeaqid tnvehmivdp pkkalatsml tgeagslpst
     1141 hmvvagmans tpqqqkcres csspstvgss lttrkidppa vpatgqfmri qnvgqkkaee
     1201 spaeiiiqvk tkellspgyp levvfylpls lqgyssvcys lslqlqcggg aqwas
//
LOCUS       XP_054225383            1254 aa            linear   PRI 05-AUG-2025
DEFINITION  BRCA2-interacting transcriptional repressor EMSY isoform X22 [Homo
            sapiens].
ACCESSION   XP_054225383
VERSION     XP_054225383.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369408.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1254
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1254
                     /product="BRCA2-interacting transcriptional repressor EMSY
                     isoform X22"
                     /calculated_mol_wt=133752
     Region          17..86
                     /region_name="ENT"
                     /note="ENT domain; pfam03735"
                     /db_xref="CDD:461032"
     Region          <470..571
                     /region_name="COG3889"
                     /note="Extracellular solute-binding protein, contains
                     Ig-fold domain [General function prediction only]"
                     /db_xref="CDD:443097"
     Region          <882..1053
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     CDS             1..1254
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /coded_by="XM_054369408.1:151..3915"
                     /db_xref="GeneID:56946"
                     /db_xref="HGNC:HGNC:18071"
                     /db_xref="MIM:608574"
ORIGIN      
        1 mpvvwptlld lsrdeckril rkleleayag visalraqgd ltkekkdllg elskvlsist
       61 erhraevrra vnderlttia hnmsgpnsss ewsiegrrlv plmprlvpqt aftvtanava
      121 naaiqhnasl pvpaetgske vvvcysytst tstptstpvp sgsiatvksp rpaspasnvv
      181 vlpsgstvyv ksvscsdede kprkrrrtns sssspvvlke vpkavvpvsk titvpvsgsp
      241 kmsnimqsia nslpphmspv kitftkpstq ttntttqkvi ivttspsstf vpnilskshn
      301 yaavtklvpt sviasttqkp pvvitasqss lvsnsssgss sstpspipnt vavtavvsst
      361 psvvmstvaq gvstsaikma strlpspksl vsaptqilaq fpkqhqqspk qqlyqvqqqt
      421 qqqvaqpspv shqqqpqqsp lppgikptiq ikqesgvkii tqqvqpskil pkpvtatlpt
      481 ssnspimvvs sngaimttkl vttptgtqat ytrptvspsi grmaatpgaa tyvkttsgsi
      541 itvvpkslat lggkiissni vsgtttkitt ipmtskpnvi vvqkttgkgt tiqglpgknv
      601 vttllnagge ktiqtvptga kpailtatrp itkmivtqpk gigstvqpaa kiiptkivyg
      661 qqgktqvlik pkpvtfqatv vseqtrqlvt etlqqasrva eagnssiqeg keepqnytds
      721 sssstessqs sqvkeklesk prqptidlsq mavpiqmtqe krhspespsi avveselvae
      781 yittvshrsq pqqpsqpqrt llqhvaqsqt atqtsvvvks ipasspgait himqqalssh
      841 taftkhseel gteegeveem dtldpqtglf yrsaltqsqs akqqklsqpp leqtqlqvkt
      901 lqcfqtkqkq tihlqadqlq hklpqmpqls irhqkltplq qeqaqpkpdv qhtqhpmvak
      961 drqlptlmaq ppqtvvqvla vkttqqlpkl qqapnqpkiy vqpqtpqsqm slpassekqt
     1021 asqveqpiit qgssvtkitf egrqpptvtk itggssvpkl tspvtsispi qasektavsd
     1081 ilkmslmeaq idtnvehmiv dppkkalats mltgeagslp sthmvvagma nstpqqqkcr
     1141 escsspstvg sslttrkidp pavpatgqfm riqnvgqkka eespaeiiiq aipqyaipch
     1201 sssnvvveps gllelnnfts qqlddeetam eqdidssted gtepspsqss aers
//
LOCUS       XP_054225384            1253 aa            linear   PRI 05-AUG-2025
DEFINITION  BRCA2-interacting transcriptional repressor EMSY isoform X23 [Homo
            sapiens].
ACCESSION   XP_054225384
VERSION     XP_054225384.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369409.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1253
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1253
                     /product="BRCA2-interacting transcriptional repressor EMSY
                     isoform X23"
                     /calculated_mol_wt=133653
     Region          17..86
                     /region_name="ENT"
                     /note="ENT domain; pfam03735"
                     /db_xref="CDD:461032"
     Region          <469..570
                     /region_name="COG3889"
                     /note="Extracellular solute-binding protein, contains
                     Ig-fold domain [General function prediction only]"
                     /db_xref="CDD:443097"
     Region          <881..1052
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     CDS             1..1253
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /coded_by="XM_054369409.1:151..3912"
                     /db_xref="GeneID:56946"
                     /db_xref="HGNC:HGNC:18071"
                     /db_xref="MIM:608574"
ORIGIN      
        1 mpvvwptlld lsrdeckril rkleleayag visalraqgd ltkekkdllg elskvlsist
       61 erhraevrra vnderlttia hnmsgpnsss ewsiegrrlv plmprlvpqt aftvtanava
      121 naaiqhnasl pvpaetgske vvcysytstt stptstpvps gsiatvkspr paspasnvvv
      181 lpsgstvyvk svscsdedek prkrrrtnss ssspvvlkev pkavvpvskt itvpvsgspk
      241 msnimqsian slpphmspvk itftkpstqt tntttqkvii vttspsstfv pnilskshny
      301 aavtklvpts viasttqkpp vvitasqssl vsnsssgsss stpspipntv avtavvsstp
      361 svvmstvaqg vstsaikmas trlpspkslv saptqilaqf pkqhqqspkq qlyqvqqqtq
      421 qqvaqpspvs hqqqpqqspl ppgikptiqi kqesgvkiit qqvqpskilp kpvtatlpts
      481 snspimvvss ngaimttklv ttptgtqaty trptvspsig rmaatpgaat yvkttsgsii
      541 tvvpkslatl ggkiissniv sgtttkitti pmtskpnviv vqkttgkgtt iqglpgknvv
      601 ttllnaggek tiqtvptgak pailtatrpi tkmivtqpkg igstvqpaak iiptkivygq
      661 qgktqvlikp kpvtfqatvv seqtrqlvte tlqqasrvae agnssiqegk eepqnytdss
      721 ssstessqss qvkekleskp rqptidlsqm avpiqmtqek rhspespsia vveselvaey
      781 ittvshrsqp qqpsqpqrtl lqhvaqsqta tqtsvvvksi passpgaith imqqalssht
      841 aftkhseelg teegeveemd tldpqtglfy rsaltqsqsa kqqklsqppl eqtqlqvktl
      901 qcfqtkqkqt ihlqadqlqh klpqmpqlsi rhqkltplqq eqaqpkpdvq htqhpmvakd
      961 rqlptlmaqp pqtvvqvlav kttqqlpklq qapnqpkiyv qpqtpqsqms lpassekqta
     1021 sqveqpiitq gssvtkitfe grqpptvtki tggssvpklt spvtsispiq asektavsdi
     1081 lkmslmeaqi dtnvehmivd ppkkalatsm ltgeagslps thmvvagman stpqqqkcre
     1141 scsspstvgs slttrkidpp avpatgqfmr iqnvgqkkae espaeiiiqa ipqyaipchs
     1201 ssnvvvepsg llelnnftsq qlddeetame qdidsstedg tepspsqssa ers
//
LOCUS       XP_054225385            1251 aa            linear   PRI 05-AUG-2025
DEFINITION  BRCA2-interacting transcriptional repressor EMSY isoform X24 [Homo
            sapiens].
ACCESSION   XP_054225385
VERSION     XP_054225385.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369410.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1251
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1251
                     /product="BRCA2-interacting transcriptional repressor EMSY
                     isoform X24"
                     /calculated_mol_wt=133522
     Region          17..86
                     /region_name="ENT"
                     /note="ENT domain; pfam03735"
                     /db_xref="CDD:461032"
     Region          <470..571
                     /region_name="COG3889"
                     /note="Extracellular solute-binding protein, contains
                     Ig-fold domain [General function prediction only]"
                     /db_xref="CDD:443097"
     Region          <896..1067
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     CDS             1..1251
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /coded_by="XM_054369410.1:151..3906"
                     /db_xref="GeneID:56946"
                     /db_xref="HGNC:HGNC:18071"
                     /db_xref="MIM:608574"
ORIGIN      
        1 mpvvwptlld lsrdeckril rkleleayag visalraqgd ltkekkdllg elskvlsist
       61 erhraevrra vnderlttia hnmsgpnsss ewsiegrrlv plmprlvpqt aftvtanava
      121 naaiqhnasl pvpaetgske vvvcysytst tstptstpvp sgsiatvksp rpaspasnvv
      181 vlpsgstvyv ksvscsdede kprkrrrtns sssspvvlke vpkavvpvsk titvpvsgsp
      241 kmsnimqsia nslpphmspv kitftkpstq ttntttqkvi ivttspsstf vpnilskshn
      301 yaavtklvpt sviasttqkp pvvitasqss lvsnsssgss sstpspipnt vavtavvsst
      361 psvvmstvaq gvstsaikma strlpspksl vsaptqilaq fpkqhqqspk qqlyqvqqqt
      421 qqqvaqpspv shqqqpqqsp lppgikptiq ikqesgvkii tqqvqpskil pkpvtatlpt
      481 ssnspimvvs sngaimttkl vttptgtqat ytrptvspsi grmaatpgaa tyvkttsgsi
      541 itvvpkslat lggkiissni vsgtttkitt ipmtskpnvi vvqkttgkgt tiqglpgknv
      601 vttllnagge ktiqtvptga kpailtatrp itkmivtqpk gigstvqpaa kiiptkivyg
      661 qqgktqvlik pkpvtfqatv vseqtrqlvt etlqqasrva eagnssiqeg keepqnytds
      721 sssstessqs sqvkeklesk prqptidlsq mavpiqmtqe krhspespsi avveselvae
      781 yittertdeg tevafpllvs hrsqpqqpsq pqrtllqhva qsqtatqtsv vvksipassp
      841 gaithimqqa lsshtaftkh seelgteege veemdtldpq tglfyrsalt qsqsakqqkl
      901 sqppleqtql qvktlqcfqt kqkqtihlqa dqlqhklpqm pqlsirhqkl tplqqeqaqp
      961 kpdvqhtqhp mvakdrqlpt lmaqppqtvv qvlavkttqq lpklqqapnq pkiyvqpqtp
     1021 qsqmslpass ekqtasqveq piitqgssvt kitfegrqpp tvtkitggss vpkltspvts
     1081 ispiqasekt avsdilkmsl meaqidtnve hmivdppkka latsmltgea gslpsthmvv
     1141 agmanstpqq qkcrescssp stvgsslttr kidppavpat gqfmriqnvg qkkaeespae
     1201 iiiqvktkel lspgyplevv fylplslqgy ssvcyslslq lqcgggaqwa s
//
LOCUS       XP_054225386            1241 aa            linear   PRI 05-AUG-2025
DEFINITION  BRCA2-interacting transcriptional repressor EMSY isoform X25 [Homo
            sapiens].
ACCESSION   XP_054225386
VERSION     XP_054225386.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369411.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1241
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1241
                     /product="BRCA2-interacting transcriptional repressor EMSY
                     isoform X25"
                     /calculated_mol_wt=132948
     Region          17..86
                     /region_name="ENT"
                     /note="ENT domain; pfam03735"
                     /db_xref="CDD:461032"
     Region          <419..520
                     /region_name="COG3889"
                     /note="Extracellular solute-binding protein, contains
                     Ig-fold domain [General function prediction only]"
                     /db_xref="CDD:443097"
     Region          <886..1057
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     CDS             1..1241
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /coded_by="XM_054369411.1:151..3876"
                     /db_xref="GeneID:56946"
                     /db_xref="HGNC:HGNC:18071"
                     /db_xref="MIM:608574"
ORIGIN      
        1 mpvvwptlld lsrdeckril rkleleayag visalraqgd ltkekkdllg elskvlsist
       61 erhraevrra vnderlttia hnmsgpnsss ewsiegrrlv plmprlvpqt aftvtanava
      121 naaiqhnasl pvpaetgske gvscsdedek prkrrrtnss ssspvvlkev pkavvpvskt
      181 itvpvsgspk msnimqsian slpphmspvk itftkpstqt tntttqkvii vttspsstfv
      241 pnilskshny aavtklvpts viasttqkpp vvitasqssl vsnsssgsss stpspipntv
      301 avtavvsstp svvmstvaqg vstsaikmas trlpspkslv saptqilaqf pkqhqqspkq
      361 qlyqvqqqtq qqvaqpspvs hqqqpqqspl ppgikptiqi kqesgvkiit qqvqpskilp
      421 kpvtatlpts snspimvvss ngaimttklv ttptgtqaty trptvspsig rmaatpgaat
      481 yvkttsgsii tvvpkslatl ggkiissniv sgtttkitti pmtskpnviv vqkttgkgtt
      541 iqglpgknvv ttllnaggek tiqtvptgak pailtatrpi tkmivtqpkg igstvqpaak
      601 iiptkivygq qgktqvlikp kpvtfqatvv seqtrqlvte tlqqasrvae agnssiqegk
      661 eepqnytdss ssstessqss qdsqpvvhvi asrrqdwseh eiametspti iyqdvssesq
      721 satstikall elqqttvkek leskprqpti dlsqmavpiq mtqekrhspe spsiavvese
      781 lvaeyittvs hrsqpqqpsq pqrtllqhva qsqtatqtsv vvksipassp gaithimqqa
      841 lsshtaftkh seelgteege veemdtldpq tglfyrsalt qsqsakqqkl sqppleqtql
      901 qvktlqcfqt kqkqtihlqa dqlqhklpqm pqlsirhqkl tplqqeqaqp kpdvqhtqhp
      961 mvakdrqlpt lmaqppqtvv qvlavkttqq lpklqqapnq pkiyvqpqtp qsqmslpass
     1021 ekqtasqveq piitqgssvt kitfegrqpp tvtkitggss vpkltspvts ispiqasekt
     1081 avsdilkmsl meaqidtnve hmivdppkka latsmltgea gslpsthmvv agmanstpqq
     1141 qkcrescssp stvgsslttr kidppavpat gqfmriqnvg qkkaeespae iiiqvktkel
     1201 lspgyplevv fylplslqgy ssvcyslslq lqcgggaqwa s
//
LOCUS       XP_054225387            1231 aa            linear   PRI 05-AUG-2025
DEFINITION  BRCA2-interacting transcriptional repressor EMSY isoform X26 [Homo
            sapiens].
ACCESSION   XP_054225387
VERSION     XP_054225387.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369412.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1231
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1231
                     /product="BRCA2-interacting transcriptional repressor EMSY
                     isoform X26"
                     /calculated_mol_wt=131796
     Region          17..81
                     /region_name="ENT"
                     /note="ENT domain; pfam03735"
                     /db_xref="CDD:461032"
     Region          <433..534
                     /region_name="COG3889"
                     /note="Extracellular solute-binding protein, contains
                     Ig-fold domain [General function prediction only]"
                     /db_xref="CDD:443097"
     Region          <859..1030
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     CDS             1..1231
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /coded_by="XM_054369412.1:151..3846"
                     /db_xref="GeneID:56946"
                     /db_xref="HGNC:HGNC:18071"
                     /db_xref="MIM:608574"
ORIGIN      
        1 mpvvwptlld lsrdeckril rkleleayag visalraqgd ltkekkdllg elskvlsist
       61 erhraevrra vnderlttia hkmnlslylg erpsysmsgp nsssewsieg rrlvplmprl
      121 vpqtaftvta navanaaiqh naslpvpaet gskegvscsd edekprkrrr tnssssspvv
      181 lkevpkavvp vsktitvpvs gspkmsnimq sianslpphm spvkitftkp stqttntttq
      241 kviivttsps stfvpnilsk shnyaavtkl vptsviastt qkppvvitas qsslvsnsss
      301 gsssstpspi pntvavtavv sstpsvvmst vaqgvstsai kmastrlpsp kslvsaptqi
      361 laqfpkqhqq spkqqlyqvq qqtqqqvaqp spvshqqqpq qsplppgikp tiqikqesgv
      421 kiitqqvqps kilpkpvtat lptssnspim vvssngaimt tklvttptgt qatytrptvs
      481 psigrmaatp gaatyvktts gsiitvvpks latlggkiis snivsgtttk ittipmtskp
      541 nvivvqkttg kgttiqglpg knvvttllna ggektiqtvp tgakpailta trpitkmivt
      601 qpkgigstvq paakiiptki vygqqgktqv likpkpvtfq atvvseqtrq lvtetlqqas
      661 rvaeagnssi qegkeepqny tdssssstes sqssqvkekl eskprqptid lsqmavpiqm
      721 tqekrhspes psiavvesel vaeyittert degtevafpl lvshrsqpqq psqpqrtllq
      781 hvaqsqtatq tsvvvksipa sspgaithim qqalsshtaf tkhseelgte egeveemdtl
      841 dpqtglfyrs altqsqsakq qklsqppleq tqlqvktlqc fqtkqkqtih lqadqlqhkl
      901 pqmpqlsirh qkltplqqeq aqpkpdvqht qhpmvakdrq lptlmaqppq tvvqvlavkt
      961 tqqlpklqqa pnqpkiyvqp qtpqsqmslp assekqtasq veqpiitqgs svtkitfegr
     1021 qpptvtkitg gssvpkltsp vtsispiqas ektavsdilk mslmeaqidt nvehmivdpp
     1081 kkalatsmlt geagslpsth mvvagmanst pqqqkcresc sspstvgssl ttrkidppav
     1141 patgqfmriq nvgqkkaees paeiiiqaip qyaipchsss nvvvepsgll elnnftsqql
     1201 ddeetameqd idsstedgte pspsqssaer s
//
LOCUS       XP_054225388            1217 aa            linear   PRI 05-AUG-2025
DEFINITION  BRCA2-interacting transcriptional repressor EMSY isoform X27 [Homo
            sapiens].
ACCESSION   XP_054225388
VERSION     XP_054225388.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369413.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1217
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1217
                     /product="BRCA2-interacting transcriptional repressor EMSY
                     isoform X27"
                     /calculated_mol_wt=130170
     Region          17..86
                     /region_name="ENT"
                     /note="ENT domain; pfam03735"
                     /db_xref="CDD:461032"
     Region          <419..520
                     /region_name="COG3889"
                     /note="Extracellular solute-binding protein, contains
                     Ig-fold domain [General function prediction only]"
                     /db_xref="CDD:443097"
     Region          <845..1016
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     CDS             1..1217
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /coded_by="XM_054369413.1:151..3804"
                     /db_xref="GeneID:56946"
                     /db_xref="HGNC:HGNC:18071"
                     /db_xref="MIM:608574"
ORIGIN      
        1 mpvvwptlld lsrdeckril rkleleayag visalraqgd ltkekkdllg elskvlsist
       61 erhraevrra vnderlttia hnmsgpnsss ewsiegrrlv plmprlvpqt aftvtanava
      121 naaiqhnasl pvpaetgske gvscsdedek prkrrrtnss ssspvvlkev pkavvpvskt
      181 itvpvsgspk msnimqsian slpphmspvk itftkpstqt tntttqkvii vttspsstfv
      241 pnilskshny aavtklvpts viasttqkpp vvitasqssl vsnsssgsss stpspipntv
      301 avtavvsstp svvmstvaqg vstsaikmas trlpspkslv saptqilaqf pkqhqqspkq
      361 qlyqvqqqtq qqvaqpspvs hqqqpqqspl ppgikptiqi kqesgvkiit qqvqpskilp
      421 kpvtatlpts snspimvvss ngaimttklv ttptgtqaty trptvspsig rmaatpgaat
      481 yvkttsgsii tvvpkslatl ggkiissniv sgtttkitti pmtskpnviv vqkttgkgtt
      541 iqglpgknvv ttllnaggek tiqtvptgak pailtatrpi tkmivtqpkg igstvqpaak
      601 iiptkivygq qgktqvlikp kpvtfqatvv seqtrqlvte tlqqasrvae agnssiqegk
      661 eepqnytdss ssstessqss qvkekleskp rqptidlsqm avpiqmtqek rhspespsia
      721 vveselvaey ittertdegt evafpllvsh rsqpqqpsqp qrtllqhvaq sqtatqtsvv
      781 vksipasspg aithimqqal sshtaftkhs eelgteegev eemdtldpqt glfyrsaltq
      841 sqsakqqkls qppleqtqlq vktlqcfqtk qkqtihlqad qlqhklpqmp qlsirhqklt
      901 plqqeqaqpk pdvqhtqhpm vakdrqlptl maqppqtvvq vlavkttqql pklqqapnqp
      961 kiyvqpqtpq sqmslpasse kqtasqveqp iitqgssvtk itfegrqppt vtkitggssv
     1021 pkltspvtsi spiqasekta vsdilkmslm eaqidtnveh mivdppkkal atsmltgeag
     1081 slpsthmvva gmanstpqqq kcrescssps tvgsslttrk idppavpatg qfmriqnvgq
     1141 kkaeespaei iiqaipqyai pchsssnvvv epsgllelnn ftsqqlddee tameqdidss
     1201 tedgtepsps qssaers
//
LOCUS       XP_054225389            1217 aa            linear   PRI 05-AUG-2025
DEFINITION  BRCA2-interacting transcriptional repressor EMSY isoform X28 [Homo
            sapiens].
ACCESSION   XP_054225389
VERSION     XP_054225389.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369414.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1217
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1217
                     /product="BRCA2-interacting transcriptional repressor EMSY
                     isoform X28"
                     /calculated_mol_wt=130237
     Region          17..81
                     /region_name="ENT"
                     /note="ENT domain; pfam03735"
                     /db_xref="CDD:461032"
     Region          <433..534
                     /region_name="COG3889"
                     /note="Extracellular solute-binding protein, contains
                     Ig-fold domain [General function prediction only]"
                     /db_xref="CDD:443097"
     Region          <845..1016
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     CDS             1..1217
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /coded_by="XM_054369414.1:151..3804"
                     /db_xref="GeneID:56946"
                     /db_xref="HGNC:HGNC:18071"
                     /db_xref="MIM:608574"
ORIGIN      
        1 mpvvwptlld lsrdeckril rkleleayag visalraqgd ltkekkdllg elskvlsist
       61 erhraevrra vnderlttia hkmnlslylg erpsysmsgp nsssewsieg rrlvplmprl
      121 vpqtaftvta navanaaiqh naslpvpaet gskegvscsd edekprkrrr tnssssspvv
      181 lkevpkavvp vsktitvpvs gspkmsnimq sianslpphm spvkitftkp stqttntttq
      241 kviivttsps stfvpnilsk shnyaavtkl vptsviastt qkppvvitas qsslvsnsss
      301 gsssstpspi pntvavtavv sstpsvvmst vaqgvstsai kmastrlpsp kslvsaptqi
      361 laqfpkqhqq spkqqlyqvq qqtqqqvaqp spvshqqqpq qsplppgikp tiqikqesgv
      421 kiitqqvqps kilpkpvtat lptssnspim vvssngaimt tklvttptgt qatytrptvs
      481 psigrmaatp gaatyvktts gsiitvvpks latlggkiis snivsgtttk ittipmtskp
      541 nvivvqkttg kgttiqglpg knvvttllna ggektiqtvp tgakpailta trpitkmivt
      601 qpkgigstvq paakiiptki vygqqgktqv likpkpvtfq atvvseqtrq lvtetlqqas
      661 rvaeagnssi qegkeepqny tdssssstes sqssqvkekl eskprqptid lsqmavpiqm
      721 tqekrhspes psiavvesel vaeyittvsh rsqpqqpsqp qrtllqhvaq sqtatqtsvv
      781 vksipasspg aithimqqal sshtaftkhs eelgteegev eemdtldpqt glfyrsaltq
      841 sqsakqqkls qppleqtqlq vktlqcfqtk qkqtihlqad qlqhklpqmp qlsirhqklt
      901 plqqeqaqpk pdvqhtqhpm vakdrqlptl maqppqtvvq vlavkttqql pklqqapnqp
      961 kiyvqpqtpq sqmslpasse kqtasqveqp iitqgssvtk itfegrqppt vtkitggssv
     1021 pkltspvtsi spiqasekta vsdilkmslm eaqidtnveh mivdppkkal atsmltgeag
     1081 slpsthmvva gmanstpqqq kcrescssps tvgsslttrk idppavpatg qfmriqnvgq
     1141 kkaeespaei iiqaipqyai pchsssnvvv epsgllelnn ftsqqlddee tameqdidss
     1201 tedgtepsps qssaers
//
LOCUS       XP_054225390            1216 aa            linear   PRI 05-AUG-2025
DEFINITION  BRCA2-interacting transcriptional repressor EMSY isoform X29 [Homo
            sapiens].
ACCESSION   XP_054225390
VERSION     XP_054225390.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369415.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1216
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1216
                     /product="BRCA2-interacting transcriptional repressor EMSY
                     isoform X29"
                     /calculated_mol_wt=129545
     Region          17..81
                     /region_name="ENT"
                     /note="ENT domain; pfam03735"
                     /db_xref="CDD:461032"
     Region          <484..585
                     /region_name="COG3889"
                     /note="Extracellular solute-binding protein, contains
                     Ig-fold domain [General function prediction only]"
                     /db_xref="CDD:443097"
     Region          <844..1015
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     CDS             1..1216
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /coded_by="XM_054369415.1:151..3801"
                     /db_xref="GeneID:56946"
                     /db_xref="HGNC:HGNC:18071"
                     /db_xref="MIM:608574"
ORIGIN      
        1 mpvvwptlld lsrdeckril rkleleayag visalraqgd ltkekkdllg elskvlsist
       61 erhraevrra vnderlttia hkmnlslylg erpsysmsgp nsssewsieg rrlvplmprl
      121 vpqtaftvta navanaaiqh naslpvpaet gskevvvcys ytsttstpts tpvpsgsiat
      181 vksprpaspa snvvvlpsgs tvyvksvscs dedekprkrr rtnssssspv vlkevpkavv
      241 pvsktitvpv sgspkmsnim qsianslpph mspvkitftk pstqttnttt qkviivttsp
      301 sstfvpnils kshnyaavtk lvptsviast tqkppvvita sqsslvsnss sgsssstpsp
      361 ipntvavtav vsstpsvvms tvaqgvstsa ikmastrlps pkslvsaptq ilaqfpkqhq
      421 qspkqqlyqv qqqtqqqvaq pspvshqqqp qqsplppgik ptiqikqesg vkiitqqvqp
      481 skilpkpvta tlptssnspi mvvssngaim ttklvttptg tqatytrptv spsigrmaat
      541 pgaatyvktt sgsiitvvpk slatlggkii ssnivsgttt kittipmtsk pnvivvqktt
      601 gkgttiqglp gknvvttlln aggektiqtv ptgakpailt atrpitkmiv tqpkgigstv
      661 qpaakiiptk ivygqqgktq vlikpkpvtf qatvvseqtr qlvtetlqqa srvaeagnss
      721 iqegkeepqn ytdssssste ssqssqvshr sqpqqpsqpq rtllqhvaqs qtatqtsvvv
      781 ksipasspga ithimqqals shtaftkhse elgteegeve emdtldpqtg lfyrsaltqs
      841 qsakqqklsq ppleqtqlqv ktlqcfqtkq kqtihlqadq lqhklpqmpq lsirhqkltp
      901 lqqeqaqpkp dvqhtqhpmv akdrqlptlm aqppqtvvqv lavkttqqlp klqqapnqpk
      961 iyvqpqtpqs qmslpassek qtasqveqpi itqgssvtki tfegrqpptv tkitggssvp
     1021 kltspvtsis piqasektav sdilkmslme aqidtnvehm ivdppkkala tsmltgeags
     1081 lpsthmvvag manstpqqqk crescsspst vgsslttrki dppavpatgq fmriqnvgqk
     1141 kaeespaeii iqaipqyaip chsssnvvve psgllelnnf tsqqlddeet ameqdidsst
     1201 edgtepspsq ssaers
//
LOCUS       XP_054225391            1215 aa            linear   PRI 05-AUG-2025
DEFINITION  BRCA2-interacting transcriptional repressor EMSY isoform X30 [Homo
            sapiens].
ACCESSION   XP_054225391
VERSION     XP_054225391.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369416.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1215
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1215
                     /product="BRCA2-interacting transcriptional repressor EMSY
                     isoform X30"
                     /calculated_mol_wt=129446
     Region          17..81
                     /region_name="ENT"
                     /note="ENT domain; pfam03735"
                     /db_xref="CDD:461032"
     Region          <483..584
                     /region_name="COG3889"
                     /note="Extracellular solute-binding protein, contains
                     Ig-fold domain [General function prediction only]"
                     /db_xref="CDD:443097"
     Region          <843..1014
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     CDS             1..1215
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /coded_by="XM_054369416.1:151..3798"
                     /db_xref="GeneID:56946"
                     /db_xref="HGNC:HGNC:18071"
                     /db_xref="MIM:608574"
ORIGIN      
        1 mpvvwptlld lsrdeckril rkleleayag visalraqgd ltkekkdllg elskvlsist
       61 erhraevrra vnderlttia hkmnlslylg erpsysmsgp nsssewsieg rrlvplmprl
      121 vpqtaftvta navanaaiqh naslpvpaet gskevvcysy tsttstptst pvpsgsiatv
      181 ksprpaspas nvvvlpsgst vyvksvscsd edekprkrrr tnssssspvv lkevpkavvp
      241 vsktitvpvs gspkmsnimq sianslpphm spvkitftkp stqttntttq kviivttsps
      301 stfvpnilsk shnyaavtkl vptsviastt qkppvvitas qsslvsnsss gsssstpspi
      361 pntvavtavv sstpsvvmst vaqgvstsai kmastrlpsp kslvsaptqi laqfpkqhqq
      421 spkqqlyqvq qqtqqqvaqp spvshqqqpq qsplppgikp tiqikqesgv kiitqqvqps
      481 kilpkpvtat lptssnspim vvssngaimt tklvttptgt qatytrptvs psigrmaatp
      541 gaatyvktts gsiitvvpks latlggkiis snivsgtttk ittipmtskp nvivvqkttg
      601 kgttiqglpg knvvttllna ggektiqtvp tgakpailta trpitkmivt qpkgigstvq
      661 paakiiptki vygqqgktqv likpkpvtfq atvvseqtrq lvtetlqqas rvaeagnssi
      721 qegkeepqny tdssssstes sqssqvshrs qpqqpsqpqr tllqhvaqsq tatqtsvvvk
      781 sipasspgai thimqqalss htaftkhsee lgteegevee mdtldpqtgl fyrsaltqsq
      841 sakqqklsqp pleqtqlqvk tlqcfqtkqk qtihlqadql qhklpqmpql sirhqkltpl
      901 qqeqaqpkpd vqhtqhpmva kdrqlptlma qppqtvvqvl avkttqqlpk lqqapnqpki
      961 yvqpqtpqsq mslpassekq tasqveqpii tqgssvtkit fegrqpptvt kitggssvpk
     1021 ltspvtsisp iqasektavs dilkmslmea qidtnvehmi vdppkkalat smltgeagsl
     1081 psthmvvagm anstpqqqkc rescsspstv gsslttrkid ppavpatgqf mriqnvgqkk
     1141 aeespaeiii qaipqyaipc hsssnvvvep sgllelnnft sqqlddeeta meqdidsste
     1201 dgtepspsqs saers
//
LOCUS       XP_054225392            1203 aa            linear   PRI 05-AUG-2025
DEFINITION  BRCA2-interacting transcriptional repressor EMSY isoform X31 [Homo
            sapiens].
ACCESSION   XP_054225392
VERSION     XP_054225392.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369417.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1203
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1203
                     /product="BRCA2-interacting transcriptional repressor EMSY
                     isoform X31"
                     /calculated_mol_wt=128611
     Region          17..86
                     /region_name="ENT"
                     /note="ENT domain; pfam03735"
                     /db_xref="CDD:461032"
     Region          <419..520
                     /region_name="COG3889"
                     /note="Extracellular solute-binding protein, contains
                     Ig-fold domain [General function prediction only]"
                     /db_xref="CDD:443097"
     Region          <831..1002
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     CDS             1..1203
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /coded_by="XM_054369417.1:151..3762"
                     /db_xref="GeneID:56946"
                     /db_xref="HGNC:HGNC:18071"
                     /db_xref="MIM:608574"
ORIGIN      
        1 mpvvwptlld lsrdeckril rkleleayag visalraqgd ltkekkdllg elskvlsist
       61 erhraevrra vnderlttia hnmsgpnsss ewsiegrrlv plmprlvpqt aftvtanava
      121 naaiqhnasl pvpaetgske gvscsdedek prkrrrtnss ssspvvlkev pkavvpvskt
      181 itvpvsgspk msnimqsian slpphmspvk itftkpstqt tntttqkvii vttspsstfv
      241 pnilskshny aavtklvpts viasttqkpp vvitasqssl vsnsssgsss stpspipntv
      301 avtavvsstp svvmstvaqg vstsaikmas trlpspkslv saptqilaqf pkqhqqspkq
      361 qlyqvqqqtq qqvaqpspvs hqqqpqqspl ppgikptiqi kqesgvkiit qqvqpskilp
      421 kpvtatlpts snspimvvss ngaimttklv ttptgtqaty trptvspsig rmaatpgaat
      481 yvkttsgsii tvvpkslatl ggkiissniv sgtttkitti pmtskpnviv vqkttgkgtt
      541 iqglpgknvv ttllnaggek tiqtvptgak pailtatrpi tkmivtqpkg igstvqpaak
      601 iiptkivygq qgktqvlikp kpvtfqatvv seqtrqlvte tlqqasrvae agnssiqegk
      661 eepqnytdss ssstessqss qvkekleskp rqptidlsqm avpiqmtqek rhspespsia
      721 vveselvaey ittvshrsqp qqpsqpqrtl lqhvaqsqta tqtsvvvksi passpgaith
      781 imqqalssht aftkhseelg teegeveemd tldpqtglfy rsaltqsqsa kqqklsqppl
      841 eqtqlqvktl qcfqtkqkqt ihlqadqlqh klpqmpqlsi rhqkltplqq eqaqpkpdvq
      901 htqhpmvakd rqlptlmaqp pqtvvqvlav kttqqlpklq qapnqpkiyv qpqtpqsqms
      961 lpassekqta sqveqpiitq gssvtkitfe grqpptvtki tggssvpklt spvtsispiq
     1021 asektavsdi lkmslmeaqi dtnvehmivd ppkkalatsm ltgeagslps thmvvagman
     1081 stpqqqkcre scsspstvgs slttrkidpp avpatgqfmr iqnvgqkkae espaeiiiqa
     1141 ipqyaipchs ssnvvvepsg llelnnftsq qlddeetame qdidsstedg tepspsqssa
     1201 ers
//
LOCUS       XP_054225393            1202 aa            linear   PRI 05-AUG-2025
DEFINITION  BRCA2-interacting transcriptional repressor EMSY isoform X32 [Homo
            sapiens].
ACCESSION   XP_054225393
VERSION     XP_054225393.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369418.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1202
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1202
                     /product="BRCA2-interacting transcriptional repressor EMSY
                     isoform X32"
                     /calculated_mol_wt=127919
     Region          17..86
                     /region_name="ENT"
                     /note="ENT domain; pfam03735"
                     /db_xref="CDD:461032"
     Region          <470..571
                     /region_name="COG3889"
                     /note="Extracellular solute-binding protein, contains
                     Ig-fold domain [General function prediction only]"
                     /db_xref="CDD:443097"
     Region          <830..1001
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     CDS             1..1202
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /coded_by="XM_054369418.1:151..3759"
                     /db_xref="GeneID:56946"
                     /db_xref="HGNC:HGNC:18071"
                     /db_xref="MIM:608574"
ORIGIN      
        1 mpvvwptlld lsrdeckril rkleleayag visalraqgd ltkekkdllg elskvlsist
       61 erhraevrra vnderlttia hnmsgpnsss ewsiegrrlv plmprlvpqt aftvtanava
      121 naaiqhnasl pvpaetgske vvvcysytst tstptstpvp sgsiatvksp rpaspasnvv
      181 vlpsgstvyv ksvscsdede kprkrrrtns sssspvvlke vpkavvpvsk titvpvsgsp
      241 kmsnimqsia nslpphmspv kitftkpstq ttntttqkvi ivttspsstf vpnilskshn
      301 yaavtklvpt sviasttqkp pvvitasqss lvsnsssgss sstpspipnt vavtavvsst
      361 psvvmstvaq gvstsaikma strlpspksl vsaptqilaq fpkqhqqspk qqlyqvqqqt
      421 qqqvaqpspv shqqqpqqsp lppgikptiq ikqesgvkii tqqvqpskil pkpvtatlpt
      481 ssnspimvvs sngaimttkl vttptgtqat ytrptvspsi grmaatpgaa tyvkttsgsi
      541 itvvpkslat lggkiissni vsgtttkitt ipmtskpnvi vvqkttgkgt tiqglpgknv
      601 vttllnagge ktiqtvptga kpailtatrp itkmivtqpk gigstvqpaa kiiptkivyg
      661 qqgktqvlik pkpvtfqatv vseqtrqlvt etlqqasrva eagnssiqeg keepqnytds
      721 sssstessqs sqvshrsqpq qpsqpqrtll qhvaqsqtat qtsvvvksip asspgaithi
      781 mqqalsshta ftkhseelgt eegeveemdt ldpqtglfyr saltqsqsak qqklsqpple
      841 qtqlqvktlq cfqtkqkqti hlqadqlqhk lpqmpqlsir hqkltplqqe qaqpkpdvqh
      901 tqhpmvakdr qlptlmaqpp qtvvqvlavk ttqqlpklqq apnqpkiyvq pqtpqsqmsl
      961 passekqtas qveqpiitqg ssvtkitfeg rqpptvtkit ggssvpklts pvtsispiqa
     1021 sektavsdil kmslmeaqid tnvehmivdp pkkalatsml tgeagslpst hmvvagmans
     1081 tpqqqkcres csspstvgss lttrkidppa vpatgqfmri qnvgqkkaee spaeiiiqai
     1141 pqyaipchss snvvvepsgl lelnnftsqq lddeetameq didsstedgt epspsqssae
     1201 rs
//
LOCUS       XP_054225394            1201 aa            linear   PRI 05-AUG-2025
DEFINITION  BRCA2-interacting transcriptional repressor EMSY isoform X47 [Homo
            sapiens].
ACCESSION   XP_054225394
VERSION     XP_054225394.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369419.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1201
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1201
                     /product="BRCA2-interacting transcriptional repressor EMSY
                     isoform X47"
                     /calculated_mol_wt=127820
     Region          17..86
                     /region_name="ENT"
                     /note="ENT domain; pfam03735"
                     /db_xref="CDD:461032"
     Region          <469..570
                     /region_name="COG3889"
                     /note="Extracellular solute-binding protein, contains
                     Ig-fold domain [General function prediction only]"
                     /db_xref="CDD:443097"
     Region          <829..1000
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     CDS             1..1201
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /coded_by="XM_054369419.1:151..3756"
                     /db_xref="GeneID:56946"
                     /db_xref="HGNC:HGNC:18071"
                     /db_xref="MIM:608574"
ORIGIN      
        1 mpvvwptlld lsrdeckril rkleleayag visalraqgd ltkekkdllg elskvlsist
       61 erhraevrra vnderlttia hnmsgpnsss ewsiegrrlv plmprlvpqt aftvtanava
      121 naaiqhnasl pvpaetgske vvcysytstt stptstpvps gsiatvkspr paspasnvvv
      181 lpsgstvyvk svscsdedek prkrrrtnss ssspvvlkev pkavvpvskt itvpvsgspk
      241 msnimqsian slpphmspvk itftkpstqt tntttqkvii vttspsstfv pnilskshny
      301 aavtklvpts viasttqkpp vvitasqssl vsnsssgsss stpspipntv avtavvsstp
      361 svvmstvaqg vstsaikmas trlpspkslv saptqilaqf pkqhqqspkq qlyqvqqqtq
      421 qqvaqpspvs hqqqpqqspl ppgikptiqi kqesgvkiit qqvqpskilp kpvtatlpts
      481 snspimvvss ngaimttklv ttptgtqaty trptvspsig rmaatpgaat yvkttsgsii
      541 tvvpkslatl ggkiissniv sgtttkitti pmtskpnviv vqkttgkgtt iqglpgknvv
      601 ttllnaggek tiqtvptgak pailtatrpi tkmivtqpkg igstvqpaak iiptkivygq
      661 qgktqvlikp kpvtfqatvv seqtrqlvte tlqqasrvae agnssiqegk eepqnytdss
      721 ssstessqss qvshrsqpqq psqpqrtllq hvaqsqtatq tsvvvksipa sspgaithim
      781 qqalsshtaf tkhseelgte egeveemdtl dpqtglfyrs altqsqsakq qklsqppleq
      841 tqlqvktlqc fqtkqkqtih lqadqlqhkl pqmpqlsirh qkltplqqeq aqpkpdvqht
      901 qhpmvakdrq lptlmaqppq tvvqvlavkt tqqlpklqqa pnqpkiyvqp qtpqsqmslp
      961 assekqtasq veqpiitqgs svtkitfegr qpptvtkitg gssvpkltsp vtsispiqas
     1021 ektavsdilk mslmeaqidt nvehmivdpp kkalatsmlt geagslpsth mvvagmanst
     1081 pqqqkcresc sspstvgssl ttrkidppav patgqfmriq nvgqkkaees paeiiiqaip
     1141 qyaipchsss nvvvepsgll elnnftsqql ddeetameqd idsstedgte pspsqssaer
     1201 s
//
LOCUS       XP_054225395            1199 aa            linear   PRI 05-AUG-2025
DEFINITION  BRCA2-interacting transcriptional repressor EMSY isoform X33 [Homo
            sapiens].
ACCESSION   XP_054225395
VERSION     XP_054225395.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369420.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1199
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1199
                     /product="BRCA2-interacting transcriptional repressor EMSY
                     isoform X33"
                     /calculated_mol_wt=127757
     Region          17..81
                     /region_name="ENT"
                     /note="ENT domain; pfam03735"
                     /db_xref="CDD:461032"
     Region          <484..585
                     /region_name="COG3889"
                     /note="Extracellular solute-binding protein, contains
                     Ig-fold domain [General function prediction only]"
                     /db_xref="CDD:443097"
     Region          <844..1015
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     CDS             1..1199
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /coded_by="XM_054369420.1:151..3750"
                     /db_xref="GeneID:56946"
                     /db_xref="HGNC:HGNC:18071"
                     /db_xref="MIM:608574"
ORIGIN      
        1 mpvvwptlld lsrdeckril rkleleayag visalraqgd ltkekkdllg elskvlsist
       61 erhraevrra vnderlttia hkmnlslylg erpsysmsgp nsssewsieg rrlvplmprl
      121 vpqtaftvta navanaaiqh naslpvpaet gskevvvcys ytsttstpts tpvpsgsiat
      181 vksprpaspa snvvvlpsgs tvyvksvscs dedekprkrr rtnssssspv vlkevpkavv
      241 pvsktitvpv sgspkmsnim qsianslpph mspvkitftk pstqttnttt qkviivttsp
      301 sstfvpnils kshnyaavtk lvptsviast tqkppvvita sqsslvsnss sgsssstpsp
      361 ipntvavtav vsstpsvvms tvaqgvstsa ikmastrlps pkslvsaptq ilaqfpkqhq
      421 qspkqqlyqv qqqtqqqvaq pspvshqqqp qqsplppgik ptiqikqesg vkiitqqvqp
      481 skilpkpvta tlptssnspi mvvssngaim ttklvttptg tqatytrptv spsigrmaat
      541 pgaatyvktt sgsiitvvpk slatlggkii ssnivsgttt kittipmtsk pnvivvqktt
      601 gkgttiqglp gknvvttlln aggektiqtv ptgakpailt atrpitkmiv tqpkgigstv
      661 qpaakiiptk ivygqqgktq vlikpkpvtf qatvvseqtr qlvtetlqqa srvaeagnss
      721 iqegkeepqn ytdssssste ssqssqvshr sqpqqpsqpq rtllqhvaqs qtatqtsvvv
      781 ksipasspga ithimqqals shtaftkhse elgteegeve emdtldpqtg lfyrsaltqs
      841 qsakqqklsq ppleqtqlqv ktlqcfqtkq kqtihlqadq lqhklpqmpq lsirhqkltp
      901 lqqeqaqpkp dvqhtqhpmv akdrqlptlm aqppqtvvqv lavkttqqlp klqqapnqpk
      961 iyvqpqtpqs qmslpassek qtasqveqpi itqgssvtki tfegrqpptv tkitggssvp
     1021 kltspvtsis piqasektav sdilkmslme aqidtnvehm ivdppkkala tsmltgeags
     1081 lpsthmvvag manstpqqqk crescsspst vgsslttrki dppavpatgq fmriqnvgqk
     1141 kaeespaeii iqvktkells pgyplevvfy lplslqgyss vcyslslqlq cgggaqwas
//
LOCUS       XP_054225396            1170 aa            linear   PRI 05-AUG-2025
DEFINITION  BRCA2-interacting transcriptional repressor EMSY isoform X34 [Homo
            sapiens].
ACCESSION   XP_054225396
VERSION     XP_054225396.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369421.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1170
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1170
                     /product="BRCA2-interacting transcriptional repressor EMSY
                     isoform X34"
                     /calculated_mol_wt=125509
     Region          17..81
                     /region_name="ENT"
                     /note="ENT domain; pfam03735"
                     /db_xref="CDD:461032"
     Region          <484..585
                     /region_name="COG3889"
                     /note="Extracellular solute-binding protein, contains
                     Ig-fold domain [General function prediction only]"
                     /db_xref="CDD:443097"
     Region          <965..1102
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     CDS             1..1170
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /coded_by="XM_054369421.1:151..3663"
                     /db_xref="GeneID:56946"
                     /db_xref="HGNC:HGNC:18071"
                     /db_xref="MIM:608574"
ORIGIN      
        1 mpvvwptlld lsrdeckril rkleleayag visalraqgd ltkekkdllg elskvlsist
       61 erhraevrra vnderlttia hkmnlslylg erpsysmsgp nsssewsieg rrlvplmprl
      121 vpqtaftvta navanaaiqh naslpvpaet gskevvvcys ytsttstpts tpvpsgsiat
      181 vksprpaspa snvvvlpsgs tvyvksvscs dedekprkrr rtnssssspv vlkevpkavv
      241 pvsktitvpv sgspkmsnim qsianslpph mspvkitftk pstqttnttt qkviivttsp
      301 sstfvpnils kshnyaavtk lvptsviast tqkppvvita sqsslvsnss sgsssstpsp
      361 ipntvavtav vsstpsvvms tvaqgvstsa ikmastrlps pkslvsaptq ilaqfpkqhq
      421 qspkqqlyqv qqqtqqqvaq pspvshqqqp qqsplppgik ptiqikqesg vkiitqqvqp
      481 skilpkpvta tlptssnspi mvvssngaim ttklvttptg tqatytrptv spsigrmaat
      541 pgaatyvktt sgsiitvvpk slatlggkii ssnivsgttt kittipmtsk pnvivvqktt
      601 gkgttiqglp gknvvttlln aggektiqtv ptgakpailt atrpitkmiv tqpkgigstv
      661 qpaakiiptk ivygqqgktq vlikpkpvtf qatvvseqtr qlvtetlqqa srvaeagnss
      721 iqegkeepqn ytdssssste ssqssqdsqp vvhviasrrq dwseheiame tsptiiyqdv
      781 ssesqsatst ikallelqqt tvkekleskp rqptidlsqm avpiqmtqek rhspespsia
      841 vveselvaey ittertdegt evafpllvsh rsqpqqpsqp qrtllqhvaq sqtatqtsvv
      901 vksipasspg aithimqqal sshtaftkhs eelgteegev eemdtldpqt glfyrsaltq
      961 sqsakqqkls qppleqtqlq vktlqcfqtk qkqtihlqad qlqhklpqmp qlsirhqklt
     1021 plqqeqaqpk pdvqhtqhpm vakdrqlptl maqppqtvvq vlavkttqql pklqqapnqp
     1081 kiyvqpqtpq sqmslpasse kqtasqaipq yaipchsssn vvvepsglle lnnftsqqld
     1141 deetameqdi dsstedgtep spsqssaers
//
LOCUS       XP_054225397            1156 aa            linear   PRI 05-AUG-2025
DEFINITION  BRCA2-interacting transcriptional repressor EMSY isoform X35 [Homo
            sapiens].
ACCESSION   XP_054225397
VERSION     XP_054225397.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369422.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1156
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1156
                     /product="BRCA2-interacting transcriptional repressor EMSY
                     isoform X35"
                     /calculated_mol_wt=123883
     Region          17..86
                     /region_name="ENT"
                     /note="ENT domain; pfam03735"
                     /db_xref="CDD:461032"
     Region          <470..571
                     /region_name="COG3889"
                     /note="Extracellular solute-binding protein, contains
                     Ig-fold domain [General function prediction only]"
                     /db_xref="CDD:443097"
     Region          <951..1088
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     CDS             1..1156
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /coded_by="XM_054369422.1:151..3621"
                     /db_xref="GeneID:56946"
                     /db_xref="HGNC:HGNC:18071"
                     /db_xref="MIM:608574"
ORIGIN      
        1 mpvvwptlld lsrdeckril rkleleayag visalraqgd ltkekkdllg elskvlsist
       61 erhraevrra vnderlttia hnmsgpnsss ewsiegrrlv plmprlvpqt aftvtanava
      121 naaiqhnasl pvpaetgske vvvcysytst tstptstpvp sgsiatvksp rpaspasnvv
      181 vlpsgstvyv ksvscsdede kprkrrrtns sssspvvlke vpkavvpvsk titvpvsgsp
      241 kmsnimqsia nslpphmspv kitftkpstq ttntttqkvi ivttspsstf vpnilskshn
      301 yaavtklvpt sviasttqkp pvvitasqss lvsnsssgss sstpspipnt vavtavvsst
      361 psvvmstvaq gvstsaikma strlpspksl vsaptqilaq fpkqhqqspk qqlyqvqqqt
      421 qqqvaqpspv shqqqpqqsp lppgikptiq ikqesgvkii tqqvqpskil pkpvtatlpt
      481 ssnspimvvs sngaimttkl vttptgtqat ytrptvspsi grmaatpgaa tyvkttsgsi
      541 itvvpkslat lggkiissni vsgtttkitt ipmtskpnvi vvqkttgkgt tiqglpgknv
      601 vttllnagge ktiqtvptga kpailtatrp itkmivtqpk gigstvqpaa kiiptkivyg
      661 qqgktqvlik pkpvtfqatv vseqtrqlvt etlqqasrva eagnssiqeg keepqnytds
      721 sssstessqs sqdsqpvvhv iasrrqdwse heiametspt iiyqdvsses qsatstikal
      781 lelqqttvke kleskprqpt idlsqmavpi qmtqekrhsp espsiavves elvaeyitte
      841 rtdegtevaf pllvshrsqp qqpsqpqrtl lqhvaqsqta tqtsvvvksi passpgaith
      901 imqqalssht aftkhseelg teegeveemd tldpqtglfy rsaltqsqsa kqqklsqppl
      961 eqtqlqvktl qcfqtkqkqt ihlqadqlqh klpqmpqlsi rhqkltplqq eqaqpkpdvq
     1021 htqhpmvakd rqlptlmaqp pqtvvqvlav kttqqlpklq qapnqpkiyv qpqtpqsqms
     1081 lpassekqta sqaipqyaip chsssnvvve psgllelnnf tsqqlddeet ameqdidsst
     1141 edgtepspsq ssaers
//
LOCUS       XP_054225398            1156 aa            linear   PRI 05-AUG-2025
DEFINITION  BRCA2-interacting transcriptional repressor EMSY isoform X36 [Homo
            sapiens].
ACCESSION   XP_054225398
VERSION     XP_054225398.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369423.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1156
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1156
                     /product="BRCA2-interacting transcriptional repressor EMSY
                     isoform X36"
                     /calculated_mol_wt=123950
     Region          17..81
                     /region_name="ENT"
                     /note="ENT domain; pfam03735"
                     /db_xref="CDD:461032"
     Region          <484..585
                     /region_name="COG3889"
                     /note="Extracellular solute-binding protein, contains
                     Ig-fold domain [General function prediction only]"
                     /db_xref="CDD:443097"
     Region          <951..1088
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     CDS             1..1156
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /coded_by="XM_054369423.1:151..3621"
                     /db_xref="GeneID:56946"
                     /db_xref="HGNC:HGNC:18071"
                     /db_xref="MIM:608574"
ORIGIN      
        1 mpvvwptlld lsrdeckril rkleleayag visalraqgd ltkekkdllg elskvlsist
       61 erhraevrra vnderlttia hkmnlslylg erpsysmsgp nsssewsieg rrlvplmprl
      121 vpqtaftvta navanaaiqh naslpvpaet gskevvvcys ytsttstpts tpvpsgsiat
      181 vksprpaspa snvvvlpsgs tvyvksvscs dedekprkrr rtnssssspv vlkevpkavv
      241 pvsktitvpv sgspkmsnim qsianslpph mspvkitftk pstqttnttt qkviivttsp
      301 sstfvpnils kshnyaavtk lvptsviast tqkppvvita sqsslvsnss sgsssstpsp
      361 ipntvavtav vsstpsvvms tvaqgvstsa ikmastrlps pkslvsaptq ilaqfpkqhq
      421 qspkqqlyqv qqqtqqqvaq pspvshqqqp qqsplppgik ptiqikqesg vkiitqqvqp
      481 skilpkpvta tlptssnspi mvvssngaim ttklvttptg tqatytrptv spsigrmaat
      541 pgaatyvktt sgsiitvvpk slatlggkii ssnivsgttt kittipmtsk pnvivvqktt
      601 gkgttiqglp gknvvttlln aggektiqtv ptgakpailt atrpitkmiv tqpkgigstv
      661 qpaakiiptk ivygqqgktq vlikpkpvtf qatvvseqtr qlvtetlqqa srvaeagnss
      721 iqegkeepqn ytdssssste ssqssqdsqp vvhviasrrq dwseheiame tsptiiyqdv
      781 ssesqsatst ikallelqqt tvkekleskp rqptidlsqm avpiqmtqek rhspespsia
      841 vveselvaey ittvshrsqp qqpsqpqrtl lqhvaqsqta tqtsvvvksi passpgaith
      901 imqqalssht aftkhseelg teegeveemd tldpqtglfy rsaltqsqsa kqqklsqppl
      961 eqtqlqvktl qcfqtkqkqt ihlqadqlqh klpqmpqlsi rhqkltplqq eqaqpkpdvq
     1021 htqhpmvakd rqlptlmaqp pqtvvqvlav kttqqlpklq qapnqpkiyv qpqtpqsqms
     1081 lpassekqta sqaipqyaip chsssnvvve psgllelnnf tsqqlddeet ameqdidsst
     1141 edgtepspsq ssaers
//
LOCUS       XP_054225399            1155 aa            linear   PRI 05-AUG-2025
DEFINITION  BRCA2-interacting transcriptional repressor EMSY isoform X37 [Homo
            sapiens].
ACCESSION   XP_054225399
VERSION     XP_054225399.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369424.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1155
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1155
                     /product="BRCA2-interacting transcriptional repressor EMSY
                     isoform X37"
                     /calculated_mol_wt=123784
     Region          17..86
                     /region_name="ENT"
                     /note="ENT domain; pfam03735"
                     /db_xref="CDD:461032"
     Region          <469..570
                     /region_name="COG3889"
                     /note="Extracellular solute-binding protein, contains
                     Ig-fold domain [General function prediction only]"
                     /db_xref="CDD:443097"
     Region          <950..1087
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     CDS             1..1155
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /coded_by="XM_054369424.1:151..3618"
                     /db_xref="GeneID:56946"
                     /db_xref="HGNC:HGNC:18071"
                     /db_xref="MIM:608574"
ORIGIN      
        1 mpvvwptlld lsrdeckril rkleleayag visalraqgd ltkekkdllg elskvlsist
       61 erhraevrra vnderlttia hnmsgpnsss ewsiegrrlv plmprlvpqt aftvtanava
      121 naaiqhnasl pvpaetgske vvcysytstt stptstpvps gsiatvkspr paspasnvvv
      181 lpsgstvyvk svscsdedek prkrrrtnss ssspvvlkev pkavvpvskt itvpvsgspk
      241 msnimqsian slpphmspvk itftkpstqt tntttqkvii vttspsstfv pnilskshny
      301 aavtklvpts viasttqkpp vvitasqssl vsnsssgsss stpspipntv avtavvsstp
      361 svvmstvaqg vstsaikmas trlpspkslv saptqilaqf pkqhqqspkq qlyqvqqqtq
      421 qqvaqpspvs hqqqpqqspl ppgikptiqi kqesgvkiit qqvqpskilp kpvtatlpts
      481 snspimvvss ngaimttklv ttptgtqaty trptvspsig rmaatpgaat yvkttsgsii
      541 tvvpkslatl ggkiissniv sgtttkitti pmtskpnviv vqkttgkgtt iqglpgknvv
      601 ttllnaggek tiqtvptgak pailtatrpi tkmivtqpkg igstvqpaak iiptkivygq
      661 qgktqvlikp kpvtfqatvv seqtrqlvte tlqqasrvae agnssiqegk eepqnytdss
      721 ssstessqss qdsqpvvhvi asrrqdwseh eiametspti iyqdvssesq satstikall
      781 elqqttvkek leskprqpti dlsqmavpiq mtqekrhspe spsiavvese lvaeyitter
      841 tdegtevafp llvshrsqpq qpsqpqrtll qhvaqsqtat qtsvvvksip asspgaithi
      901 mqqalsshta ftkhseelgt eegeveemdt ldpqtglfyr saltqsqsak qqklsqpple
      961 qtqlqvktlq cfqtkqkqti hlqadqlqhk lpqmpqlsir hqkltplqqe qaqpkpdvqh
     1021 tqhpmvakdr qlptlmaqpp qtvvqvlavk ttqqlpklqq apnqpkiyvq pqtpqsqmsl
     1081 passekqtas qaipqyaipc hsssnvvvep sgllelnnft sqqlddeeta meqdidsste
     1141 dgtepspsqs saers
//
LOCUS       XP_054225400            1142 aa            linear   PRI 05-AUG-2025
DEFINITION  BRCA2-interacting transcriptional repressor EMSY isoform X38 [Homo
            sapiens].
ACCESSION   XP_054225400
VERSION     XP_054225400.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369425.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1142
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1142
                     /product="BRCA2-interacting transcriptional repressor EMSY
                     isoform X38"
                     /calculated_mol_wt=122324
     Region          17..86
                     /region_name="ENT"
                     /note="ENT domain; pfam03735"
                     /db_xref="CDD:461032"
     Region          <470..571
                     /region_name="COG3889"
                     /note="Extracellular solute-binding protein, contains
                     Ig-fold domain [General function prediction only]"
                     /db_xref="CDD:443097"
     Region          <937..1074
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     CDS             1..1142
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /coded_by="XM_054369425.1:151..3579"
                     /db_xref="GeneID:56946"
                     /db_xref="HGNC:HGNC:18071"
                     /db_xref="MIM:608574"
ORIGIN      
        1 mpvvwptlld lsrdeckril rkleleayag visalraqgd ltkekkdllg elskvlsist
       61 erhraevrra vnderlttia hnmsgpnsss ewsiegrrlv plmprlvpqt aftvtanava
      121 naaiqhnasl pvpaetgske vvvcysytst tstptstpvp sgsiatvksp rpaspasnvv
      181 vlpsgstvyv ksvscsdede kprkrrrtns sssspvvlke vpkavvpvsk titvpvsgsp
      241 kmsnimqsia nslpphmspv kitftkpstq ttntttqkvi ivttspsstf vpnilskshn
      301 yaavtklvpt sviasttqkp pvvitasqss lvsnsssgss sstpspipnt vavtavvsst
      361 psvvmstvaq gvstsaikma strlpspksl vsaptqilaq fpkqhqqspk qqlyqvqqqt
      421 qqqvaqpspv shqqqpqqsp lppgikptiq ikqesgvkii tqqvqpskil pkpvtatlpt
      481 ssnspimvvs sngaimttkl vttptgtqat ytrptvspsi grmaatpgaa tyvkttsgsi
      541 itvvpkslat lggkiissni vsgtttkitt ipmtskpnvi vvqkttgkgt tiqglpgknv
      601 vttllnagge ktiqtvptga kpailtatrp itkmivtqpk gigstvqpaa kiiptkivyg
      661 qqgktqvlik pkpvtfqatv vseqtrqlvt etlqqasrva eagnssiqeg keepqnytds
      721 sssstessqs sqdsqpvvhv iasrrqdwse heiametspt iiyqdvsses qsatstikal
      781 lelqqttvke kleskprqpt idlsqmavpi qmtqekrhsp espsiavves elvaeyittv
      841 shrsqpqqps qpqrtllqhv aqsqtatqts vvvksipass pgaithimqq alsshtaftk
      901 hseelgteeg eveemdtldp qtglfyrsal tqsqsakqqk lsqppleqtq lqvktlqcfq
      961 tkqkqtihlq adqlqhklpq mpqlsirhqk ltplqqeqaq pkpdvqhtqh pmvakdrqlp
     1021 tlmaqppqtv vqvlavkttq qlpklqqapn qpkiyvqpqt pqsqmslpas sekqtasqai
     1081 pqyaipchss snvvvepsgl lelnnftsqq lddeetameq didsstedgt epspsqssae
     1141 rs
//
LOCUS       XP_054225401            1141 aa            linear   PRI 05-AUG-2025
DEFINITION  BRCA2-interacting transcriptional repressor EMSY isoform X39 [Homo
            sapiens].
ACCESSION   XP_054225401
VERSION     XP_054225401.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369426.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1141
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1141
                     /product="BRCA2-interacting transcriptional repressor EMSY
                     isoform X39"
                     /calculated_mol_wt=122225
     Region          17..86
                     /region_name="ENT"
                     /note="ENT domain; pfam03735"
                     /db_xref="CDD:461032"
     Region          <469..570
                     /region_name="COG3889"
                     /note="Extracellular solute-binding protein, contains
                     Ig-fold domain [General function prediction only]"
                     /db_xref="CDD:443097"
     Region          <936..1073
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     CDS             1..1141
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /coded_by="XM_054369426.1:151..3576"
                     /db_xref="GeneID:56946"
                     /db_xref="HGNC:HGNC:18071"
                     /db_xref="MIM:608574"
ORIGIN      
        1 mpvvwptlld lsrdeckril rkleleayag visalraqgd ltkekkdllg elskvlsist
       61 erhraevrra vnderlttia hnmsgpnsss ewsiegrrlv plmprlvpqt aftvtanava
      121 naaiqhnasl pvpaetgske vvcysytstt stptstpvps gsiatvkspr paspasnvvv
      181 lpsgstvyvk svscsdedek prkrrrtnss ssspvvlkev pkavvpvskt itvpvsgspk
      241 msnimqsian slpphmspvk itftkpstqt tntttqkvii vttspsstfv pnilskshny
      301 aavtklvpts viasttqkpp vvitasqssl vsnsssgsss stpspipntv avtavvsstp
      361 svvmstvaqg vstsaikmas trlpspkslv saptqilaqf pkqhqqspkq qlyqvqqqtq
      421 qqvaqpspvs hqqqpqqspl ppgikptiqi kqesgvkiit qqvqpskilp kpvtatlpts
      481 snspimvvss ngaimttklv ttptgtqaty trptvspsig rmaatpgaat yvkttsgsii
      541 tvvpkslatl ggkiissniv sgtttkitti pmtskpnviv vqkttgkgtt iqglpgknvv
      601 ttllnaggek tiqtvptgak pailtatrpi tkmivtqpkg igstvqpaak iiptkivygq
      661 qgktqvlikp kpvtfqatvv seqtrqlvte tlqqasrvae agnssiqegk eepqnytdss
      721 ssstessqss qdsqpvvhvi asrrqdwseh eiametspti iyqdvssesq satstikall
      781 elqqttvkek leskprqpti dlsqmavpiq mtqekrhspe spsiavvese lvaeyittvs
      841 hrsqpqqpsq pqrtllqhva qsqtatqtsv vvksipassp gaithimqqa lsshtaftkh
      901 seelgteege veemdtldpq tglfyrsalt qsqsakqqkl sqppleqtql qvktlqcfqt
      961 kqkqtihlqa dqlqhklpqm pqlsirhqkl tplqqeqaqp kpdvqhtqhp mvakdrqlpt
     1021 lmaqppqtvv qvlavkttqq lpklqqapnq pkiyvqpqtp qsqmslpass ekqtasqaip
     1081 qyaipchsss nvvvepsgll elnnftsqql ddeetameqd idsstedgte pspsqssaer
     1141 s
//
LOCUS       XP_054225402            1119 aa            linear   PRI 05-AUG-2025
DEFINITION  BRCA2-interacting transcriptional repressor EMSY isoform X40 [Homo
            sapiens].
ACCESSION   XP_054225402
VERSION     XP_054225402.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369427.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1119
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1119
                     /product="BRCA2-interacting transcriptional repressor EMSY
                     isoform X40"
                     /calculated_mol_wt=120368
     Region          17..81
                     /region_name="ENT"
                     /note="ENT domain; pfam03735"
                     /db_xref="CDD:461032"
     Region          <433..534
                     /region_name="COG3889"
                     /note="Extracellular solute-binding protein, contains
                     Ig-fold domain [General function prediction only]"
                     /db_xref="CDD:443097"
     Region          <914..1051
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     CDS             1..1119
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /coded_by="XM_054369427.1:151..3510"
                     /db_xref="GeneID:56946"
                     /db_xref="HGNC:HGNC:18071"
                     /db_xref="MIM:608574"
ORIGIN      
        1 mpvvwptlld lsrdeckril rkleleayag visalraqgd ltkekkdllg elskvlsist
       61 erhraevrra vnderlttia hkmnlslylg erpsysmsgp nsssewsieg rrlvplmprl
      121 vpqtaftvta navanaaiqh naslpvpaet gskegvscsd edekprkrrr tnssssspvv
      181 lkevpkavvp vsktitvpvs gspkmsnimq sianslpphm spvkitftkp stqttntttq
      241 kviivttsps stfvpnilsk shnyaavtkl vptsviastt qkppvvitas qsslvsnsss
      301 gsssstpspi pntvavtavv sstpsvvmst vaqgvstsai kmastrlpsp kslvsaptqi
      361 laqfpkqhqq spkqqlyqvq qqtqqqvaqp spvshqqqpq qsplppgikp tiqikqesgv
      421 kiitqqvqps kilpkpvtat lptssnspim vvssngaimt tklvttptgt qatytrptvs
      481 psigrmaatp gaatyvktts gsiitvvpks latlggkiis snivsgtttk ittipmtskp
      541 nvivvqkttg kgttiqglpg knvvttllna ggektiqtvp tgakpailta trpitkmivt
      601 qpkgigstvq paakiiptki vygqqgktqv likpkpvtfq atvvseqtrq lvtetlqqas
      661 rvaeagnssi qegkeepqny tdssssstes sqssqdsqpv vhviasrrqd wseheiamet
      721 sptiiyqdvs sesqsatsti kallelqqtt vkekleskpr qptidlsqma vpiqmtqekr
      781 hspespsiav veselvaeyi ttertdegte vafpllvshr sqpqqpsqpq rtllqhvaqs
      841 qtatqtsvvv ksipasspga ithimqqals shtaftkhse elgteegeve emdtldpqtg
      901 lfyrsaltqs qsakqqklsq ppleqtqlqv ktlqcfqtkq kqtihlqadq lqhklpqmpq
      961 lsirhqkltp lqqeqaqpkp dvqhtqhpmv akdrqlptlm aqppqtvvqv lavkttqqlp
     1021 klqqapnqpk iyvqpqtpqs qmslpassek qtasqaipqy aipchsssnv vvepsgllel
     1081 nnftsqqldd eetameqdid sstedgteps psqssaers
//
LOCUS       XP_054225403            1105 aa            linear   PRI 05-AUG-2025
DEFINITION  BRCA2-interacting transcriptional repressor EMSY isoform X41 [Homo
            sapiens].
ACCESSION   XP_054225403
VERSION     XP_054225403.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369428.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1105
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1105
                     /product="BRCA2-interacting transcriptional repressor EMSY
                     isoform X41"
                     /calculated_mol_wt=118742
     Region          17..86
                     /region_name="ENT"
                     /note="ENT domain; pfam03735"
                     /db_xref="CDD:461032"
     Region          <419..520
                     /region_name="COG3889"
                     /note="Extracellular solute-binding protein, contains
                     Ig-fold domain [General function prediction only]"
                     /db_xref="CDD:443097"
     Region          <900..1037
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     CDS             1..1105
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /coded_by="XM_054369428.1:151..3468"
                     /db_xref="GeneID:56946"
                     /db_xref="HGNC:HGNC:18071"
                     /db_xref="MIM:608574"
ORIGIN      
        1 mpvvwptlld lsrdeckril rkleleayag visalraqgd ltkekkdllg elskvlsist
       61 erhraevrra vnderlttia hnmsgpnsss ewsiegrrlv plmprlvpqt aftvtanava
      121 naaiqhnasl pvpaetgske gvscsdedek prkrrrtnss ssspvvlkev pkavvpvskt
      181 itvpvsgspk msnimqsian slpphmspvk itftkpstqt tntttqkvii vttspsstfv
      241 pnilskshny aavtklvpts viasttqkpp vvitasqssl vsnsssgsss stpspipntv
      301 avtavvsstp svvmstvaqg vstsaikmas trlpspkslv saptqilaqf pkqhqqspkq
      361 qlyqvqqqtq qqvaqpspvs hqqqpqqspl ppgikptiqi kqesgvkiit qqvqpskilp
      421 kpvtatlpts snspimvvss ngaimttklv ttptgtqaty trptvspsig rmaatpgaat
      481 yvkttsgsii tvvpkslatl ggkiissniv sgtttkitti pmtskpnviv vqkttgkgtt
      541 iqglpgknvv ttllnaggek tiqtvptgak pailtatrpi tkmivtqpkg igstvqpaak
      601 iiptkivygq qgktqvlikp kpvtfqatvv seqtrqlvte tlqqasrvae agnssiqegk
      661 eepqnytdss ssstessqss qdsqpvvhvi asrrqdwseh eiametspti iyqdvssesq
      721 satstikall elqqttvkek leskprqpti dlsqmavpiq mtqekrhspe spsiavvese
      781 lvaeyitter tdegtevafp llvshrsqpq qpsqpqrtll qhvaqsqtat qtsvvvksip
      841 asspgaithi mqqalsshta ftkhseelgt eegeveemdt ldpqtglfyr saltqsqsak
      901 qqklsqpple qtqlqvktlq cfqtkqkqti hlqadqlqhk lpqmpqlsir hqkltplqqe
      961 qaqpkpdvqh tqhpmvakdr qlptlmaqpp qtvvqvlavk ttqqlpklqq apnqpkiyvq
     1021 pqtpqsqmsl passekqtas qaipqyaipc hsssnvvvep sgllelnnft sqqlddeeta
     1081 meqdidsste dgtepspsqs saers
//
LOCUS       XP_054225404            1105 aa            linear   PRI 05-AUG-2025
DEFINITION  BRCA2-interacting transcriptional repressor EMSY isoform X42 [Homo
            sapiens].
ACCESSION   XP_054225404
VERSION     XP_054225404.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369429.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1105
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1105
                     /product="BRCA2-interacting transcriptional repressor EMSY
                     isoform X42"
                     /calculated_mol_wt=118809
     Region          17..81
                     /region_name="ENT"
                     /note="ENT domain; pfam03735"
                     /db_xref="CDD:461032"
     Region          <433..534
                     /region_name="COG3889"
                     /note="Extracellular solute-binding protein, contains
                     Ig-fold domain [General function prediction only]"
                     /db_xref="CDD:443097"
     Region          <900..1037
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     CDS             1..1105
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /coded_by="XM_054369429.1:151..3468"
                     /db_xref="GeneID:56946"
                     /db_xref="HGNC:HGNC:18071"
                     /db_xref="MIM:608574"
ORIGIN      
        1 mpvvwptlld lsrdeckril rkleleayag visalraqgd ltkekkdllg elskvlsist
       61 erhraevrra vnderlttia hkmnlslylg erpsysmsgp nsssewsieg rrlvplmprl
      121 vpqtaftvta navanaaiqh naslpvpaet gskegvscsd edekprkrrr tnssssspvv
      181 lkevpkavvp vsktitvpvs gspkmsnimq sianslpphm spvkitftkp stqttntttq
      241 kviivttsps stfvpnilsk shnyaavtkl vptsviastt qkppvvitas qsslvsnsss
      301 gsssstpspi pntvavtavv sstpsvvmst vaqgvstsai kmastrlpsp kslvsaptqi
      361 laqfpkqhqq spkqqlyqvq qqtqqqvaqp spvshqqqpq qsplppgikp tiqikqesgv
      421 kiitqqvqps kilpkpvtat lptssnspim vvssngaimt tklvttptgt qatytrptvs
      481 psigrmaatp gaatyvktts gsiitvvpks latlggkiis snivsgtttk ittipmtskp
      541 nvivvqkttg kgttiqglpg knvvttllna ggektiqtvp tgakpailta trpitkmivt
      601 qpkgigstvq paakiiptki vygqqgktqv likpkpvtfq atvvseqtrq lvtetlqqas
      661 rvaeagnssi qegkeepqny tdssssstes sqssqdsqpv vhviasrrqd wseheiamet
      721 sptiiyqdvs sesqsatsti kallelqqtt vkekleskpr qptidlsqma vpiqmtqekr
      781 hspespsiav veselvaeyi ttvshrsqpq qpsqpqrtll qhvaqsqtat qtsvvvksip
      841 asspgaithi mqqalsshta ftkhseelgt eegeveemdt ldpqtglfyr saltqsqsak
      901 qqklsqpple qtqlqvktlq cfqtkqkqti hlqadqlqhk lpqmpqlsir hqkltplqqe
      961 qaqpkpdvqh tqhpmvakdr qlptlmaqpp qtvvqvlavk ttqqlpklqq apnqpkiyvq
     1021 pqtpqsqmsl passekqtas qaipqyaipc hsssnvvvep sgllelnnft sqqlddeeta
     1081 meqdidsste dgtepspsqs saers
//
LOCUS       XP_054225405            1101 aa            linear   PRI 05-AUG-2025
DEFINITION  BRCA2-interacting transcriptional repressor EMSY isoform X43 [Homo
            sapiens].
ACCESSION   XP_054225405
VERSION     XP_054225405.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369430.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1101
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1101
                     /product="BRCA2-interacting transcriptional repressor EMSY
                     isoform X43"
                     /calculated_mol_wt=117757
     Region          17..86
                     /region_name="ENT"
                     /note="ENT domain; pfam03735"
                     /db_xref="CDD:461032"
     Region          <470..571
                     /region_name="COG3889"
                     /note="Extracellular solute-binding protein, contains
                     Ig-fold domain [General function prediction only]"
                     /db_xref="CDD:443097"
     Region          <896..1033
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     CDS             1..1101
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /coded_by="XM_054369430.1:151..3456"
                     /db_xref="GeneID:56946"
                     /db_xref="HGNC:HGNC:18071"
                     /db_xref="MIM:608574"
ORIGIN      
        1 mpvvwptlld lsrdeckril rkleleayag visalraqgd ltkekkdllg elskvlsist
       61 erhraevrra vnderlttia hnmsgpnsss ewsiegrrlv plmprlvpqt aftvtanava
      121 naaiqhnasl pvpaetgske vvvcysytst tstptstpvp sgsiatvksp rpaspasnvv
      181 vlpsgstvyv ksvscsdede kprkrrrtns sssspvvlke vpkavvpvsk titvpvsgsp
      241 kmsnimqsia nslpphmspv kitftkpstq ttntttqkvi ivttspsstf vpnilskshn
      301 yaavtklvpt sviasttqkp pvvitasqss lvsnsssgss sstpspipnt vavtavvsst
      361 psvvmstvaq gvstsaikma strlpspksl vsaptqilaq fpkqhqqspk qqlyqvqqqt
      421 qqqvaqpspv shqqqpqqsp lppgikptiq ikqesgvkii tqqvqpskil pkpvtatlpt
      481 ssnspimvvs sngaimttkl vttptgtqat ytrptvspsi grmaatpgaa tyvkttsgsi
      541 itvvpkslat lggkiissni vsgtttkitt ipmtskpnvi vvqkttgkgt tiqglpgknv
      601 vttllnagge ktiqtvptga kpailtatrp itkmivtqpk gigstvqpaa kiiptkivyg
      661 qqgktqvlik pkpvtfqatv vseqtrqlvt etlqqasrva eagnssiqeg keepqnytds
      721 sssstessqs sqvkeklesk prqptidlsq mavpiqmtqe krhspespsi avveselvae
      781 yittertdeg tevafpllvs hrsqpqqpsq pqrtllqhva qsqtatqtsv vvksipassp
      841 gaithimqqa lsshtaftkh seelgteege veemdtldpq tglfyrsalt qsqsakqqkl
      901 sqppleqtql qvktlqcfqt kqkqtihlqa dqlqhklpqm pqlsirhqkl tplqqeqaqp
      961 kpdvqhtqhp mvakdrqlpt lmaqppqtvv qvlavkttqq lpklqqapnq pkiyvqpqtp
     1021 qsqmslpass ekqtasqaip qyaipchsss nvvvepsgll elnnftsqql ddeetameqd
     1081 idsstedgte pspsqssaer s
//
LOCUS       XP_054225406             982 aa            linear   PRI 05-AUG-2025
DEFINITION  BRCA2-interacting transcriptional repressor EMSY isoform X46 [Homo
            sapiens].
ACCESSION   XP_054225406
VERSION     XP_054225406.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369431.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..982
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..982
                     /product="BRCA2-interacting transcriptional repressor EMSY
                     isoform X46"
                     /calculated_mol_wt=104321
     Region          17..81
                     /region_name="ENT"
                     /note="ENT domain; pfam03735"
                     /db_xref="CDD:461032"
     Region          <484..585
                     /region_name="COG3889"
                     /note="Extracellular solute-binding protein, contains
                     Ig-fold domain [General function prediction only]"
                     /db_xref="CDD:443097"
     CDS             1..982
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /coded_by="XM_054369431.1:151..3099"
                     /db_xref="GeneID:56946"
                     /db_xref="HGNC:HGNC:18071"
                     /db_xref="MIM:608574"
ORIGIN      
        1 mpvvwptlld lsrdeckril rkleleayag visalraqgd ltkekkdllg elskvlsist
       61 erhraevrra vnderlttia hkmnlslylg erpsysmsgp nsssewsieg rrlvplmprl
      121 vpqtaftvta navanaaiqh naslpvpaet gskevvvcys ytsttstpts tpvpsgsiat
      181 vksprpaspa snvvvlpsgs tvyvksvscs dedekprkrr rtnssssspv vlkevpkavv
      241 pvsktitvpv sgspkmsnim qsianslpph mspvkitftk pstqttnttt qkviivttsp
      301 sstfvpnils kshnyaavtk lvptsviast tqkppvvita sqsslvsnss sgsssstpsp
      361 ipntvavtav vsstpsvvms tvaqgvstsa ikmastrlps pkslvsaptq ilaqfpkqhq
      421 qspkqqlyqv qqqtqqqvaq pspvshqqqp qqsplppgik ptiqikqesg vkiitqqvqp
      481 skilpkpvta tlptssnspi mvvssngaim ttklvttptg tqatytrptv spsigrmaat
      541 pgaatyvktt sgsiitvvpk slatlggkii ssnivsgttt kittipmtsk pnvivvqktt
      601 gkgttiqglp gknvvttlln aggektiqtv ptgakpailt atrpitkmiv tqpkgigstv
      661 qpaakiiptk ivygqqgktq vlikpkpvtf qatvvseqtr qlvtetlqqa srvaeagnss
      721 iqegkeepqn ytdssssste ssqssqdsqp vvhviasrrq dwseheiame tsptiiyqdv
      781 ssesqsatst ikallelqqt tvkekleskp rqptidlsqm avpiqmtqek rhspespsia
      841 vveselvaey ittertdegt evafpllvsh rsqpqqpsqp qrtllqhvaq sqtatqtsvv
      901 vksipasspg aithimqqai pqyaipchss snvvvepsgl lelnnftsqq lddeetameq
      961 didsstedgt epspsqssae rs
//
LOCUS       XP_054225407             927 aa            linear   PRI 05-AUG-2025
DEFINITION  BRCA2-interacting transcriptional repressor EMSY isoform X48 [Homo
            sapiens].
ACCESSION   XP_054225407
VERSION     XP_054225407.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369432.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..927
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..927
                     /product="BRCA2-interacting transcriptional repressor EMSY
                     isoform X48"
                     /calculated_mol_wt=98195
     Region          17..81
                     /region_name="ENT"
                     /note="ENT domain; pfam03735"
                     /db_xref="CDD:461032"
     Region          <484..585
                     /region_name="COG3889"
                     /note="Extracellular solute-binding protein, contains
                     Ig-fold domain [General function prediction only]"
                     /db_xref="CDD:443097"
     CDS             1..927
                     /gene="EMSY"
                     /gene_synonym="C11orf30; GL002"
                     /coded_by="XM_054369432.1:151..2934"
                     /db_xref="GeneID:56946"
                     /db_xref="HGNC:HGNC:18071"
                     /db_xref="MIM:608574"
ORIGIN      
        1 mpvvwptlld lsrdeckril rkleleayag visalraqgd ltkekkdllg elskvlsist
       61 erhraevrra vnderlttia hkmnlslylg erpsysmsgp nsssewsieg rrlvplmprl
      121 vpqtaftvta navanaaiqh naslpvpaet gskevvvcys ytsttstpts tpvpsgsiat
      181 vksprpaspa snvvvlpsgs tvyvksvscs dedekprkrr rtnssssspv vlkevpkavv
      241 pvsktitvpv sgspkmsnim qsianslpph mspvkitftk pstqttnttt qkviivttsp
      301 sstfvpnils kshnyaavtk lvptsviast tqkppvvita sqsslvsnss sgsssstpsp
      361 ipntvavtav vsstpsvvms tvaqgvstsa ikmastrlps pkslvsaptq ilaqfpkqhq
      421 qspkqqlyqv qqqtqqqvaq pspvshqqqp qqsplppgik ptiqikqesg vkiitqqvqp
      481 skilpkpvta tlptssnspi mvvssngaim ttklvttptg tqatytrptv spsigrmaat
      541 pgaatyvktt sgsiitvvpk slatlggkii ssnivsgttt kittipmtsk pnvivvqktt
      601 gkgttiqglp gknvvttlln aggektiqtv ptgakpailt atrpitkmiv tqpkgigstv
      661 qpaakiiptk ivygqqgktq vlikpkpvtf qatvvseqtr qlvtetlqqa srvaeagnss
      721 iqegkeepqn ytdssssste ssqssqvkek leskprqpti dlsqmavpiq mtqekrhspe
      781 spsiavvese lvaeyitter tdegtevafp llvshrsqpq qpsqpqrtll qhvaqsqtat
      841 qtsvvvksip asspgaithi mqqaipqyai pchsssnvvv epsgllelnn ftsqqlddee
      901 tameqdidss tedgtepsps qssaers
//
LOCUS       XP_054225408            1143 aa            linear   PRI 05-AUG-2025
DEFINITION  PR domain zinc finger protein 10 isoform X1 [Homo sapiens].
ACCESSION   XP_054225408
VERSION     XP_054225408.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369433.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1143
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1143
                     /product="PR domain zinc finger protein 10 isoform X1"
                     /calculated_mol_wt=129552
     Region          <173..200
                     /region_name="zf_PR_Knuckle"
                     /note="PR zinc knuckle motif; pfam18445"
                     /db_xref="CDD:375871"
     Region          203..334
                     /region_name="PR-SET_PRDM10"
                     /note="PR-SET domain found in PR domain zinc finger
                     protein 10 (PRDM10) and similar proteins; cd19194"
                     /db_xref="CDD:380971"
     Site            order(218..219,236,272,285..289,291,300..301,325)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:380971"
     Site            order(218..219,285..289,291,325)
                     /site_type="other"
                     /note="putative SAM binding site"
                     /db_xref="CDD:380971"
     Region          405..510
                     /region_name="Tristanin_u2"
                     /note="Unstructured region on methyltransferase between
                     zinc-fingers; pfam16638"
                     /db_xref="CDD:465211"
     Region          528..548
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(533,535,537,539..540,543..544,547,563,565,569..570,
                     573..574,577,591,593,595,597..598,601..602,605)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          558..578
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          586..606
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          614..634
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(619,621,623,625..626,629..630,633,647,649,653..654,
                     657..658,661,675,677,679,681..682,685..686,690)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          640..662
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          642..662
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          670..691
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          725..751
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          770..787
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          <840..>1009
                     /region_name="SP1-4_N"
                     /note="N-terminal domain of transcription factor
                     Specificity Proteins (SP) 1-4; cl41773"
                     /db_xref="CDD:425404"
     CDS             1..1143
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /coded_by="XM_054369433.1:233..3664"
                     /db_xref="GeneID:56980"
                     /db_xref="HGNC:HGNC:13995"
                     /db_xref="MIM:618319"
ORIGIN      
        1 mdskdesshv wptsaeheqn atqvhfvpdt gtvaqivytd dqvrppqqvv ytadgasyts
       61 vdgpehtlvy ihpveaaqtl ftdpgqvayv qqdataqqas lpvhnqvlps iesvdgsdpl
      121 atlqtplgrl eakeeedede dedteedeee dgedtdlddw epdpprpfdp hdlwceecnn
      181 ahasvcpkhg plhpipnrpv ltraraslpl vlyidrflgg vfskrripkr tqfgpvegpl
      241 vrgselkdcy ihlkvsldkg drkerdlhed lwfelsdetl cnwmmfvrpa qnhleqnlva
      301 yqyghhvyyt tiknvepkqe lkvwyaasya efvnqkihdi seeerkvlre qeknwpcyec
      361 nrrfisseql qqhlnshdek ldvfsrtrgr grgrgkrrfg pgrrpgrppk firleitsen
      421 geksddgtqd llhfptkeqf deaepatlng ldqpeqttip ipqlpqetqs slehepetht
      481 lhlqpqhees vvptqstlta ddmrrakrir naalqhlfir ksfrpfkclq cgkafrekdk
      541 ldqhlrfhgr egncpltcdl cnkgfissts leshmklhsd qktyscifcp esfdrldllk
      601 dhvaihindg yftcptckkr fpdfiqvkkh vrsfhsekiy qctecdkafc rpdklrlhml
      661 rhsdrkdflc stcgkqfkrk dklrehmqrm hnpereakka drisrsktfk pritstdyds
      721 ftfkcrlcmm gfrrrgmlvn hlskrhpdmk ieevpeltlp iikpnrdyfc qycdkvyksa
      781 skrkahilkn hpgaelppsi rklrpagpge pdpmlsthtq ltgtiatppv ccphcskqys
      841 sktkmvqhir kkhpefaqls ntihtpltta visatpavlt tdsatgetvv ttdlltqamt
      901 elsqtlttdy rtpqgdyqri qyipvsqsas glqqpqhiql qvvqvasats phqsqqstvd
      961 vgqlhdpqpy pqhaiqvqhi qvsgqplsps aqqaqqglsp shiqgssstq gqalqqqqqq
     1021 qqnssvqhty lpsawnsfrg ysseiqmmtl ppgqfvitds gvatpvttgq vkavtsghyv
     1081 lsesqselee kqtsalsggv qveppahsds ldpqtnsqqq ttqyiitttt ngngssevhi
     1141 tkp
//
LOCUS       XP_054225409            1113 aa            linear   PRI 05-AUG-2025
DEFINITION  PR domain zinc finger protein 10 isoform X2 [Homo sapiens].
ACCESSION   XP_054225409
VERSION     XP_054225409.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369434.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1113
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1113
                     /product="PR domain zinc finger protein 10 isoform X2"
                     /calculated_mol_wt=126252
     Region          <173..200
                     /region_name="zf_PR_Knuckle"
                     /note="PR zinc knuckle motif; pfam18445"
                     /db_xref="CDD:375871"
     Region          203..334
                     /region_name="PR-SET_PRDM10"
                     /note="PR-SET domain found in PR domain zinc finger
                     protein 10 (PRDM10) and similar proteins; cd19194"
                     /db_xref="CDD:380971"
     Site            order(218..219,236,272,285..289,291,300..301,325)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:380971"
     Site            order(218..219,285..289,291,325)
                     /site_type="other"
                     /note="putative SAM binding site"
                     /db_xref="CDD:380971"
     Region          405..510
                     /region_name="Tristanin_u2"
                     /note="Unstructured region on methyltransferase between
                     zinc-fingers; pfam16638"
                     /db_xref="CDD:465211"
     Region          532..552
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(537,539,541,543..544,547..548,551,567,569,573..574,
                     577..578,581,595,597,599,601..602,605..606,609)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          562..582
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          590..610
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          618..638
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(623,625,627,629..630,633..634,637,651,653,657..658,
                     661..662,665,679,681,683,685..686,689..690,694)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          644..666
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          646..666
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          674..695
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          729..755
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          774..791
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..1113
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /coded_by="XM_054369434.1:233..3574"
                     /db_xref="GeneID:56980"
                     /db_xref="HGNC:HGNC:13995"
                     /db_xref="MIM:618319"
ORIGIN      
        1 mdskdesshv wptsaeheqn atqvhfvpdt gtvaqivytd dqvrppqqvv ytadgasyts
       61 vdgpehtlvy ihpveaaqtl ftdpgqvayv qqdataqqas lpvhnqvlps iesvdgsdpl
      121 atlqtplgrl eakeeedede dedteedeee dgedtdlddw epdpprpfdp hdlwceecnn
      181 ahasvcpkhg plhpipnrpv ltraraslpl vlyidrflgg vfskrripkr tqfgpvegpl
      241 vrgselkdcy ihlkvsldkg drkerdlhed lwfelsdetl cnwmmfvrpa qnhleqnlva
      301 yqyghhvyyt tiknvepkqe lkvwyaasya efvnqkihdi seeerkvlre qeknwpcyec
      361 nrrfisseql qqhlnshdek ldvfsrtrgr grgrgkrrfg pgrrpgrppk firleitsen
      421 geksddgtqd llhfptkeqf deaepatlng ldqpeqttip ipqlpqetqs slehepetht
      481 lhlqpqhees vvptqstlta ddmrrakrir lelqnaalqh lfirksfrpf kclqcgkafr
      541 ekdkldqhlr fhgregncpl tcdlcnkgfi sstsleshmk lhsdqktysc ifcpesfdrl
      601 dllkdhvaih indgyftcpt ckkrfpdfiq vkkhvrsfhs ekiyqctecd kafcrpdklr
      661 lhmlrhsdrk dflcstcgkq fkrkdklreh mqrmhnpere akkadrisrs ktfkpritst
      721 dydsftfkcr lcmmgfrrrg mlvnhlskrh pdmkieevpe ltlpiikpnr dyfcqycdkv
      781 yksaskrkah ilknhpgael ppsirklrpa gpgepdpmls thtqltgtia tppvccphcs
      841 kqyssktkmv qhirkkhpef aqlsntihtp lttavisatp avlttdsatg etvvttdllt
      901 qamtelsqtl ttdyrtpqgd yqriqyipvs qsasglqqpq hiqlqvvqva svsgqplsps
      961 aqqaqqglsp shiqgssstq gqalqqqqqq qqnssvqhty lpsawnsfrg ysseiqmmtl
     1021 ppgqfvitds gvatpvttgq vkavtsghyv lsesqselee kqtsalsggv qveppahsds
     1081 ldpqtnsqqq ttqyiitttt ngngssevhi tkp
//
LOCUS       XP_054225410            1109 aa            linear   PRI 05-AUG-2025
DEFINITION  PR domain zinc finger protein 10 isoform X3 [Homo sapiens].
ACCESSION   XP_054225410
VERSION     XP_054225410.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369435.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1109
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1109
                     /product="PR domain zinc finger protein 10 isoform X3"
                     /calculated_mol_wt=125769
     Region          <173..200
                     /region_name="zf_PR_Knuckle"
                     /note="PR zinc knuckle motif; pfam18445"
                     /db_xref="CDD:375871"
     Region          203..334
                     /region_name="PR-SET_PRDM10"
                     /note="PR-SET domain found in PR domain zinc finger
                     protein 10 (PRDM10) and similar proteins; cd19194"
                     /db_xref="CDD:380971"
     Site            order(218..219,236,272,285..289,291,300..301,325)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:380971"
     Site            order(218..219,285..289,291,325)
                     /site_type="other"
                     /note="putative SAM binding site"
                     /db_xref="CDD:380971"
     Region          405..510
                     /region_name="Tristanin_u2"
                     /note="Unstructured region on methyltransferase between
                     zinc-fingers; pfam16638"
                     /db_xref="CDD:465211"
     Region          528..548
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(533,535,537,539..540,543..544,547,563,565,569..570,
                     573..574,577,591,593,595,597..598,601..602,605)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          558..578
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          586..606
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          614..634
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(619,621,623,625..626,629..630,633,647,649,653..654,
                     657..658,661,675,677,679,681..682,685..686,690)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          640..662
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          642..662
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          670..691
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          725..751
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          770..787
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..1109
                     /gene="PRDM10"
                     /gene_synonym="BHD2; PFM7; TRIS"
                     /coded_by="XM_054369435.1:233..3562"
                     /db_xref="GeneID:56980"
                     /db_xref="HGNC:HGNC:13995"
                     /db_xref="MIM:618319"
ORIGIN      
        1 mdskdesshv wptsaeheqn atqvhfvpdt gtvaqivytd dqvrppqqvv ytadgasyts
       61 vdgpehtlvy ihpveaaqtl ftdpgqvayv qqdataqqas lpvhnqvlps iesvdgsdpl
      121 atlqtplgrl eakeeedede dedteedeee dgedtdlddw epdpprpfdp hdlwceecnn
      181 ahasvcpkhg plhpipnrpv ltraraslpl vlyidrflgg vfskrripkr tqfgpvegpl
      241 vrgselkdcy ihlkvsldkg drkerdlhed lwfelsdetl cnwmmfvrpa qnhleqnlva
      301 yqyghhvyyt tiknvepkqe lkvwyaasya efvnqkihdi seeerkvlre qeknwpcyec
      361 nrrfisseql qqhlnshdek ldvfsrtrgr grgrgkrrfg pgrrpgrppk firleitsen
      421 geksddgtqd llhfptkeqf deaepatlng ldqpeqttip ipqlpqetqs slehepetht
      481 lhlqpqhees vvptqstlta ddmrrakrir naalqhlfir ksfrpfkclq cgkafrekdk
      541 ldqhlrfhgr egncpltcdl cnkgfissts leshmklhsd qktyscifcp esfdrldllk
      601 dhvaihindg yftcptckkr fpdfiqvkkh vrsfhsekiy qctecdkafc rpdklrlhml
      661 rhsdrkdflc stcgkqfkrk dklrehmqrm hnpereakka drisrsktfk pritstdyds
      721 ftfkcrlcmm gfrrrgmlvn hlskrhpdmk ieevpeltlp iikpnrdyfc qycdkvyksa
      781 skrkahilkn hpgaelppsi rklrpagpge pdpmlsthtq ltgtiatppv ccphcskqys
      841 sktkmvqhir kkhpefaqls ntihtpltta visatpavlt tdsatgetvv ttdlltqamt
      901 elsqtlttdy rtpqgdyqri qyipvsqsas glqqpqhiql qvvqvasvsg qplspsaqqa
      961 qqglspshiq gssstqgqal qqqqqqqqns svqhtylpsa wnsfrgysse iqmmtlppgq
     1021 fvitdsgvat pvttgqvkav tsghyvlses qseleekqts alsggvqvep pahsdsldpq
     1081 tnsqqqttqy iittttngng ssevhitkp
//
LOCUS       XP_054225411            1177 aa            linear   PRI 05-AUG-2025
DEFINITION  PR domain-containing protein 11 isoform X1 [Homo sapiens].
ACCESSION   XP_054225411
VERSION     XP_054225411.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369436.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1177
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1177
                     /product="PR domain-containing protein 11 isoform X1"
                     /calculated_mol_wt=134131
     Region          <75..101
                     /region_name="zf_PR_Knuckle"
                     /note="PR zinc knuckle motif; pfam18445"
                     /db_xref="CDD:375871"
     Region          109..235
                     /region_name="PR-SET_PRDM11"
                     /note="PR-SET domain found in PR domain zinc finger
                     protein 11 (PRDM11) and similar proteins; cd19195"
                     /db_xref="CDD:380972"
     Site            order(125..127,145,158..162,172,185..189,191,200..201,225)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:380972"
     Site            order(125..127,158..159,185..189,191,225)
                     /site_type="other"
                     /note="putative SAM binding site"
                     /db_xref="CDD:380972"
     CDS             1..1177
                     /gene="PRDM11"
                     /gene_synonym="PFM8"
                     /coded_by="XM_054369436.1:139..3672"
                     /db_xref="GeneID:56981"
                     /db_xref="HGNC:HGNC:13996"
                     /db_xref="MIM:616347"
ORIGIN      
        1 mtenmkecla qtnaavgdmv tvvktevcsp lrdqeygqpc srrpdssame vepkklkgkr
       61 dlivpksfqq vdfwfcescq eyfvdecpnh gppvfvsdtp vpvgipdraa ltipqgmevv
      121 kdtsgesdvr cvnevipkgh ifgpyegqis tqdksagffs wlivdknnry ksidgsdetk
      181 anwmryvvis reereqnlla fqhseriyfr acrdirpgew lrvwysedym krlhsmsqet
      241 ihrnlargek rlqrekseqv ldnpedlrgp ihlsvlrqgk spykrgfdeg dvhpqakkkk
      301 idlifkdvle aslesakvea hqlalstslv irkvpkyqdd aysqcattmt hgvqnigqtq
      361 gegdwkvpqg vskepgqled eeeepssfka dspaeaslas dphelpttsf cpncirlkkk
      421 vrelqaeldm lksgklpepp vlppqvlelp efsdpaases mvsgpaimed ddqevdsade
      481 svsndmmtat depskmssat grrirrfkqe wlkkfwflry sptlnemwch vcrqytvqss
      541 rtsafiigsk qfkihtiklh sqsnlhkkcl qlyklrmhpe kteemcrnmt llfntayhla
      601 legrpyldfr plaellrkce lkvvdqymne gdcqilihhi aralredlve rirqspclsv
      661 ildgqsddll adtvavyvqy tssdgppate flslqelgfs stesylqald rafsalgirl
      721 qdekptvglg vdganitasl rasmfmtirk tlpwllclpf mvhrphleil daisgkelpc
      781 leelennlkq llsfyryspr lmcelrstaa tlceeteflg diravrwiig eqnvlnalik
      841 dylevvahlk evssqtqrad asaialallq flmdyqsikl iyflldviav lsrlayifqg
      901 eyllvsqvdd kieeaiqeis rladspgeyl qefeenfres fngiamknlr vaeakfqsir
      961 ekicqktqvi laqrfdsrsr ifvkacqvfd laawprssee lmsygkedmv qifdhleaip
     1021 tfsrdvcreg ldprgsllme wrelkadyyt kngfkdlish ickykqrfpl lnkiiqvlkv
     1081 lptstaccek grnalqrvrk nhrsrltleq lsdlltiavn gppitnfdak raldswfeek
     1141 sgnsyalsae vlsrmsaleq kpalqtmdhg tefypdi
//
LOCUS       XP_054225412            1177 aa            linear   PRI 05-AUG-2025
DEFINITION  PR domain-containing protein 11 isoform X1 [Homo sapiens].
ACCESSION   XP_054225412
VERSION     XP_054225412.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369437.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1177
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1177
                     /product="PR domain-containing protein 11 isoform X1"
                     /calculated_mol_wt=134131
     Region          <75..101
                     /region_name="zf_PR_Knuckle"
                     /note="PR zinc knuckle motif; pfam18445"
                     /db_xref="CDD:375871"
     Region          109..235
                     /region_name="PR-SET_PRDM11"
                     /note="PR-SET domain found in PR domain zinc finger
                     protein 11 (PRDM11) and similar proteins; cd19195"
                     /db_xref="CDD:380972"
     Site            order(125..127,145,158..162,172,185..189,191,200..201,225)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:380972"
     Site            order(125..127,158..159,185..189,191,225)
                     /site_type="other"
                     /note="putative SAM binding site"
                     /db_xref="CDD:380972"
     CDS             1..1177
                     /gene="PRDM11"
                     /gene_synonym="PFM8"
                     /coded_by="XM_054369437.1:134..3667"
                     /db_xref="GeneID:56981"
                     /db_xref="HGNC:HGNC:13996"
                     /db_xref="MIM:616347"
ORIGIN      
        1 mtenmkecla qtnaavgdmv tvvktevcsp lrdqeygqpc srrpdssame vepkklkgkr
       61 dlivpksfqq vdfwfcescq eyfvdecpnh gppvfvsdtp vpvgipdraa ltipqgmevv
      121 kdtsgesdvr cvnevipkgh ifgpyegqis tqdksagffs wlivdknnry ksidgsdetk
      181 anwmryvvis reereqnlla fqhseriyfr acrdirpgew lrvwysedym krlhsmsqet
      241 ihrnlargek rlqrekseqv ldnpedlrgp ihlsvlrqgk spykrgfdeg dvhpqakkkk
      301 idlifkdvle aslesakvea hqlalstslv irkvpkyqdd aysqcattmt hgvqnigqtq
      361 gegdwkvpqg vskepgqled eeeepssfka dspaeaslas dphelpttsf cpncirlkkk
      421 vrelqaeldm lksgklpepp vlppqvlelp efsdpaases mvsgpaimed ddqevdsade
      481 svsndmmtat depskmssat grrirrfkqe wlkkfwflry sptlnemwch vcrqytvqss
      541 rtsafiigsk qfkihtiklh sqsnlhkkcl qlyklrmhpe kteemcrnmt llfntayhla
      601 legrpyldfr plaellrkce lkvvdqymne gdcqilihhi aralredlve rirqspclsv
      661 ildgqsddll adtvavyvqy tssdgppate flslqelgfs stesylqald rafsalgirl
      721 qdekptvglg vdganitasl rasmfmtirk tlpwllclpf mvhrphleil daisgkelpc
      781 leelennlkq llsfyryspr lmcelrstaa tlceeteflg diravrwiig eqnvlnalik
      841 dylevvahlk evssqtqrad asaialallq flmdyqsikl iyflldviav lsrlayifqg
      901 eyllvsqvdd kieeaiqeis rladspgeyl qefeenfres fngiamknlr vaeakfqsir
      961 ekicqktqvi laqrfdsrsr ifvkacqvfd laawprssee lmsygkedmv qifdhleaip
     1021 tfsrdvcreg ldprgsllme wrelkadyyt kngfkdlish ickykqrfpl lnkiiqvlkv
     1081 lptstaccek grnalqrvrk nhrsrltleq lsdlltiavn gppitnfdak raldswfeek
     1141 sgnsyalsae vlsrmsaleq kpalqtmdhg tefypdi
//
LOCUS       XP_054225413            1177 aa            linear   PRI 05-AUG-2025
DEFINITION  PR domain-containing protein 11 isoform X1 [Homo sapiens].
ACCESSION   XP_054225413
VERSION     XP_054225413.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369438.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 5% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1177
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1177
                     /product="PR domain-containing protein 11 isoform X1"
                     /calculated_mol_wt=134131
     Region          <75..101
                     /region_name="zf_PR_Knuckle"
                     /note="PR zinc knuckle motif; pfam18445"
                     /db_xref="CDD:375871"
     Region          109..235
                     /region_name="PR-SET_PRDM11"
                     /note="PR-SET domain found in PR domain zinc finger
                     protein 11 (PRDM11) and similar proteins; cd19195"
                     /db_xref="CDD:380972"
     Site            order(125..127,145,158..162,172,185..189,191,200..201,225)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:380972"
     Site            order(125..127,158..159,185..189,191,225)
                     /site_type="other"
                     /note="putative SAM binding site"
                     /db_xref="CDD:380972"
     CDS             1..1177
                     /gene="PRDM11"
                     /gene_synonym="PFM8"
                     /coded_by="XM_054369438.1:241..3774"
                     /db_xref="GeneID:56981"
                     /db_xref="HGNC:HGNC:13996"
                     /db_xref="MIM:616347"
ORIGIN      
        1 mtenmkecla qtnaavgdmv tvvktevcsp lrdqeygqpc srrpdssame vepkklkgkr
       61 dlivpksfqq vdfwfcescq eyfvdecpnh gppvfvsdtp vpvgipdraa ltipqgmevv
      121 kdtsgesdvr cvnevipkgh ifgpyegqis tqdksagffs wlivdknnry ksidgsdetk
      181 anwmryvvis reereqnlla fqhseriyfr acrdirpgew lrvwysedym krlhsmsqet
      241 ihrnlargek rlqrekseqv ldnpedlrgp ihlsvlrqgk spykrgfdeg dvhpqakkkk
      301 idlifkdvle aslesakvea hqlalstslv irkvpkyqdd aysqcattmt hgvqnigqtq
      361 gegdwkvpqg vskepgqled eeeepssfka dspaeaslas dphelpttsf cpncirlkkk
      421 vrelqaeldm lksgklpepp vlppqvlelp efsdpaases mvsgpaimed ddqevdsade
      481 svsndmmtat depskmssat grrirrfkqe wlkkfwflry sptlnemwch vcrqytvqss
      541 rtsafiigsk qfkihtiklh sqsnlhkkcl qlyklrmhpe kteemcrnmt llfntayhla
      601 legrpyldfr plaellrkce lkvvdqymne gdcqilihhi aralredlve rirqspclsv
      661 ildgqsddll adtvavyvqy tssdgppate flslqelgfs stesylqald rafsalgirl
      721 qdekptvglg vdganitasl rasmfmtirk tlpwllclpf mvhrphleil daisgkelpc
      781 leelennlkq llsfyryspr lmcelrstaa tlceeteflg diravrwiig eqnvlnalik
      841 dylevvahlk evssqtqrad asaialallq flmdyqsikl iyflldviav lsrlayifqg
      901 eyllvsqvdd kieeaiqeis rladspgeyl qefeenfres fngiamknlr vaeakfqsir
      961 ekicqktqvi laqrfdsrsr ifvkacqvfd laawprssee lmsygkedmv qifdhleaip
     1021 tfsrdvcreg ldprgsllme wrelkadyyt kngfkdlish ickykqrfpl lnkiiqvlkv
     1081 lptstaccek grnalqrvrk nhrsrltleq lsdlltiavn gppitnfdak raldswfeek
     1141 sgnsyalsae vlsrmsaleq kpalqtmdhg tefypdi
//
LOCUS       XP_054225414             994 aa            linear   PRI 05-AUG-2025
DEFINITION  PR domain-containing protein 11 isoform X2 [Homo sapiens].
ACCESSION   XP_054225414
VERSION     XP_054225414.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369439.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..994
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..994
                     /product="PR domain-containing protein 11 isoform X2"
                     /calculated_mol_wt=113750
     Region          <1..52
                     /region_name="SET"
                     /note="SET (Su(var)3-9, Enhancer-of-zeste, Trithorax)
                     domain superfamily; cl40432"
                     /db_xref="CDD:394802"
     Site            order(1..6,17..19,40..43)
                     /site_type="active"
                     /db_xref="CDD:380972"
     Region          195..>327
                     /region_name="Phage-scaffold"
                     /note="Bacteriophage, scaffolding protein; pfam09306"
                     /db_xref="CDD:286399"
     CDS             1..994
                     /gene="PRDM11"
                     /gene_synonym="PFM8"
                     /coded_by="XM_054369439.1:98..3082"
                     /db_xref="GeneID:56981"
                     /db_xref="HGNC:HGNC:13996"
                     /db_xref="MIM:616347"
ORIGIN      
        1 mryvvisree reqnllafqh seriyfracr dirpgewlrv wysedymkrl hsmsqetihr
       61 nlargekrlq rekseqvldn pedlrgpihl svlrqgkspy krgfdegdvh pqakkkkidl
      121 ifkdvleasl esakveahql alstslvirk vpkyqddays qcattmthgv qnigqtqgeg
      181 dwkvpqgvsk epgqledeee epssfkadsp aeaslasdph elpttsfcpn cirlkkkvre
      241 lqaeldmlks gklpeppvlp pqvlelpefs dpaasesmvs gpaimedddq evdsadesvs
      301 ndmmtatdep skmssatgrr irrfkqewlk kfwflryspt lnemwchvcr qytvqssrts
      361 afiigskqfk ihtiklhsqs nlhkkclqly klrmhpekte emcrnmtllf ntayhlaleg
      421 rpyldfrpla ellrkcelkv vdqymnegdc qilihhiara lredlverir qspclsvild
      481 gqsddlladt vavyvqytss dgppatefls lqelgfsste sylqaldraf salgirlqde
      541 kptvglgvdg anitaslras mfmtirktlp wllclpfmvh rphleildai sgkelpclee
      601 lennlkqlls fyrysprlmc elrstaatlc eeteflgdir avrwiigeqn vlnalikdyl
      661 evvahlkevs sqtqradasa ialallqflm dyqsikliyf lldviavlsr layifqgeyl
      721 lvsqvddkie eaiqeisrla dspgeylqef eenfresfng iamknlrvae akfqsireki
      781 cqktqvilaq rfdsrsrifv kacqvfdlaa wprsseelms ygkedmvqif dhleaiptfs
      841 rdvcregldp rgsllmewre lkadyytkng fkdlishick ykqrfpllnk iiqvlkvlpt
      901 staccekgrn alqrvrknhr srltleqlsd lltiavngpp itnfdakral dswfeeksgn
      961 syalsaevls rmsaleqkpa lqtmdhgtef ypdi
//
LOCUS       XP_054225415             968 aa            linear   PRI 05-AUG-2025
DEFINITION  PR domain-containing protein 11 isoform X3 [Homo sapiens].
ACCESSION   XP_054225415
VERSION     XP_054225415.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369440.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..968
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..968
                     /product="PR domain-containing protein 11 isoform X3"
                     /calculated_mol_wt=110962
     Region          <75..101
                     /region_name="zf_PR_Knuckle"
                     /note="PR zinc knuckle motif; pfam18445"
                     /db_xref="CDD:375871"
     Region          109..235
                     /region_name="PR-SET_PRDM11"
                     /note="PR-SET domain found in PR domain zinc finger
                     protein 11 (PRDM11) and similar proteins; cd19195"
                     /db_xref="CDD:380972"
     Site            order(125..127,145,158..162,172,185..189,191,200..201,225)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:380972"
     Site            order(125..127,158..159,185..189,191,225)
                     /site_type="other"
                     /note="putative SAM binding site"
                     /db_xref="CDD:380972"
     CDS             1..968
                     /gene="PRDM11"
                     /gene_synonym="PFM8"
                     /coded_by="XM_054369440.1:139..3045"
                     /db_xref="GeneID:56981"
                     /db_xref="HGNC:HGNC:13996"
                     /db_xref="MIM:616347"
ORIGIN      
        1 mtenmkecla qtnaavgdmv tvvktevcsp lrdqeygqpc srrpdssame vepkklkgkr
       61 dlivpksfqq vdfwfcescq eyfvdecpnh gppvfvsdtp vpvgipdraa ltipqgmevv
      121 kdtsgesdvr cvnevipkgh ifgpyegqis tqdksagffs wlivdknnry ksidgsdetk
      181 anwmryvvis reereqnlla fqhseriyfr acrdirpgew lrvwysedym krlhsmsqet
      241 ihrnlarase smvsgpaime dddqevdsad esvsndmmta tdepskmssa tgrrirrfkq
      301 ewlkkfwflr ysptlnemwc hvcrqytvqs srtsafiigs kqfkihtikl hsqsnlhkkc
      361 lqlyklrmhp ekteemcrnm tllfntayhl alegrpyldf rplaellrkc elkvvdqymn
      421 egdcqilihh iaralredlv erirqspcls vildgqsddl ladtvavyvq ytssdgppat
      481 eflslqelgf sstesylqal drafsalgir lqdekptvgl gvdganitas lrasmfmtir
      541 ktlpwllclp fmvhrphlei ldaisgkelp cleelennlk qllsfyrysp rlmcelrsta
      601 atlceetefl gdiravrwii geqnvlnali kdylevvahl kevssqtqra dasaialall
      661 qflmdyqsik liyflldvia vlsrlayifq geyllvsqvd dkieeaiqei srladspgey
      721 lqefeenfre sfngiamknl rvaeakfqsi rekicqktqv ilaqrfdsrs rifvkacqvf
      781 dlaawprsse elmsygkedm vqifdhleai ptfsrdvcre gldprgsllm ewrelkadyy
      841 tkngfkdlis hickykqrfp llnkiiqvlk vlptstacce kgrnalqrvr knhrsrltle
      901 qlsdlltiav ngppitnfda kraldswfee ksgnsyalsa evlsrmsale qkpalqtmdh
      961 gtefypdi
//
LOCUS       XP_054225416             516 aa            linear   PRI 05-AUG-2025
DEFINITION  PR domain-containing protein 11 isoform X4 [Homo sapiens].
ACCESSION   XP_054225416
VERSION     XP_054225416.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369441.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..516
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..516
                     /product="PR domain-containing protein 11 isoform X4"
                     /calculated_mol_wt=57029
     Region          <75..101
                     /region_name="zf_PR_Knuckle"
                     /note="PR zinc knuckle motif; pfam18445"
                     /db_xref="CDD:375871"
     Region          109..235
                     /region_name="SET"
                     /note="SET (Su(var)3-9, Enhancer-of-zeste, Trithorax)
                     domain superfamily; cl40432"
                     /db_xref="CDD:394802"
     Site            order(126..127,184..188,199,210..212,234..235)
                     /site_type="active"
                     /db_xref="CDD:380914"
     Site            order(126..127,185..188,199)
                     /site_type="other"
                     /note="SAM binding site [polypeptide binding]"
                     /db_xref="CDD:380914"
     Region          <334..404
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..516
                     /gene="PRDM11"
                     /gene_synonym="PFM8"
                     /coded_by="XM_054369441.1:139..1689"
                     /db_xref="GeneID:56981"
                     /db_xref="HGNC:HGNC:13996"
                     /db_xref="MIM:616347"
ORIGIN      
        1 mtenmkecla qtnaavgdmv tvvktevcsp lrdqeygqpc srrpdssame vepkklkgkr
       61 dlivpksfqq vdfwfcescq eyfvdecpnh gppvfvsdtp vpvgipdraa ltipqgmevv
      121 kdtsgesdvr cvnevipkgh ifgpyegqis tqdksagffs wlivdknnry ksidgsdetk
      181 anwmrnvahl aerkrkpkfs keeldilvte vthheavlfg retmrlshad rdkiwegiar
      241 kitsvsqvpr svkdikhrwd dmkrrtkdkl afmqqslsgp gaggraptiv ltaherviks
      301 alltaragrg fpraeldgtd spstsydede eapgpsrqpl rvplqrspee eahlarpall
      361 rsssssdqse tvgpkpealp hpspqaqaac rtprphpspp ttgldwqllh vhaqqtevfr
      421 qfcqelvtvh rdmansmhvi gqamaeltsr vgqmcqtlte irdgvqasqr gpegadptgs
      481 tpqatqaqap lpepppaspa saptrttrsr krkhnf
//
LOCUS       XP_054225417             477 aa            linear   PRI 05-AUG-2025
DEFINITION  PR domain-containing protein 11 isoform X5 [Homo sapiens].
ACCESSION   XP_054225417
VERSION     XP_054225417.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369442.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..477
                     /product="PR domain-containing protein 11 isoform X5"
                     /calculated_mol_wt=53734
     Region          <75..101
                     /region_name="zf_PR_Knuckle"
                     /note="PR zinc knuckle motif; pfam18445"
                     /db_xref="CDD:375871"
     Region          109..235
                     /region_name="PR-SET_PRDM11"
                     /note="PR-SET domain found in PR domain zinc finger
                     protein 11 (PRDM11) and similar proteins; cd19195"
                     /db_xref="CDD:380972"
     Site            order(125..127,145,158..162,172,185..189,191,200..201,225)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:380972"
     Site            order(125..127,158..159,185..189,191,225)
                     /site_type="other"
                     /note="putative SAM binding site"
                     /db_xref="CDD:380972"
     CDS             1..477
                     /gene="PRDM11"
                     /gene_synonym="PFM8"
                     /coded_by="XM_054369442.1:139..1572"
                     /db_xref="GeneID:56981"
                     /db_xref="HGNC:HGNC:13996"
                     /db_xref="MIM:616347"
ORIGIN      
        1 mtenmkecla qtnaavgdmv tvvktevcsp lrdqeygqpc srrpdssame vepkklkgkr
       61 dlivpksfqq vdfwfcescq eyfvdecpnh gppvfvsdtp vpvgipdraa ltipqgmevv
      121 kdtsgesdvr cvnevipkgh ifgpyegqis tqdksagffs wlivdknnry ksidgsdetk
      181 anwmryvvis reereqnlla fqhseriyfr acrdirpgew lrvwysedym krlhsmsqet
      241 ihrnlargek rlqrekseqv ldnpedlrgp ihlsvlrqgk spykrgfdeg dvhpqakkkk
      301 idlifkdvle aslesakvea hqlalstslv irkvpkyqdd aysqcattmt hgvqnigqtq
      361 gegdwkvpqg vskepgqled eeeepssfka dspaeaslas dphelpttsf cpncirlkkk
      421 vrelqaeldm lksgklpepp vlppqvlelp efsdpagklv wmrllsegrv rsglcgg
//
LOCUS       XP_054225418             202 aa            linear   PRI 05-AUG-2025
DEFINITION  calcium-binding protein 4 isoform X2 [Homo sapiens].
ACCESSION   XP_054225418
VERSION     XP_054225418.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369443.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..202
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..202
                     /product="calcium-binding protein 4 isoform X2"
                     /calculated_mol_wt=22097
     Region          <76..121
                     /region_name="KLF9_13_N-like"
                     /note="Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16,
                     and similar proteins; cl41730"
                     /db_xref="CDD:425361"
     Region          145..>192
                     /region_name="PTZ00184"
                     /note="calmodulin; Provisional"
                     /db_xref="CDD:185504"
     CDS             1..202
                     /gene="CABP4"
                     /gene_synonym="CRSD; CSNB2B"
                     /coded_by="XM_054369443.1:4..612"
                     /db_xref="GeneID:57010"
                     /db_xref="HGNC:HGNC:1386"
                     /db_xref="MIM:608965"
ORIGIN      
        1 mtswsphtiy ftgedrkvqr iseeqargqq gpnlaigrqk ppagvvtpks daeeppltrk
       61 rskkerglrg srkrtgssge qtgpeapgss nnppstgegp agappaspgp assrqshrhr
      121 pdslhdaaqr tygpllnrvf gkdrelgpee ldelqaafee fdtdrdgyis hrelgdcmrt
      181 lgymptemel lewaavwtlr sl
//
LOCUS       XP_054225419             375 aa            linear   PRI 05-AUG-2025
DEFINITION  tripartite motif-containing protein 49 isoform X2 [Homo sapiens].
ACCESSION   XP_054225419
VERSION     XP_054225419.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369444.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 29% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..375
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..375
                     /product="tripartite motif-containing protein 49 isoform
                     X2"
                     /calculated_mol_wt=43406
     Region          9..67
                     /region_name="RING-HC_TRIM43-like_C-IV"
                     /note="RING finger, HC subclass, found in tripartite
                     motif-containing proteins TRIM43, TRIM48, TRIM49, TRIM51,
                     TRIM64 and similar proteins; cd16603"
                     /db_xref="CDD:438265"
     Region          87..139
                     /region_name="Bbox2_TRIM43-like"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing proteins TRIM43, TRIM48, TRIM49, TRIM51,
                     TRIM64, TRIM77 and similar proteins; cd19783"
                     /db_xref="CDD:380841"
     Region          208..371
                     /region_name="SPRY"
                     /note="SPRY domain; cl02614"
                     /db_xref="CDD:470632"
     CDS             1..375
                     /gene="TRIM49"
                     /gene_synonym="RNF18; TRIM49A; TRIM49L2"
                     /coded_by="XM_054369444.1:5..1132"
                     /db_xref="GeneID:57093"
                     /db_xref="HGNC:HGNC:13431"
                     /db_xref="MIM:606124"
ORIGIN      
        1 mnsgilqvfq gelicplcmn yfidpvtidc ghsfcrpcfy lnwqdipflv qcsectkste
       61 qinlktnihl kkmaslarkv slwlflssee qmcgthretk kifcevdrsl lcllcsssqe
      121 hryhrhrpie waaeehrekl lqkmqslwek acenhrnlnv ettrtrcwka fgdilhrses
      181 vllhmpqpln pelsagpitg lrdrlnqfrv hitlhheean ndiflyeilr smcigcdhqd
      241 vpyftatprs flawgvqtft sgkyywevhv gdswnwafgv cnmyrkeknq nekidgkagl
      301 fllgcvkndi qcslfttspl mlqyipkpts rvglfldcea ktvsfvdvnq ssliytipnc
      361 sfspplrlif ccihf
//
LOCUS       XP_054225420             310 aa            linear   PRI 05-AUG-2025
DEFINITION  26S proteasome non-ATPase regulatory subunit 13 isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225420
VERSION     XP_054225420.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369445.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..310
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..310
                     /product="26S proteasome non-ATPase regulatory subunit 13
                     isoform X1"
                     /calculated_mol_wt=35259
     CDS             1..310
                     /gene="PSMD13"
                     /gene_synonym="HSPC027; p40.5; Rpn9; S11"
                     /coded_by="XM_054369445.1:75..1007"
                     /db_xref="GeneID:5719"
                     /db_xref="HGNC:HGNC:9558"
                     /db_xref="MIM:603481"
ORIGIN      
        1 mkdvpgflqq sqssgpgqpa vwhrleelyt kklwhqltlq vldfvqdpcf aqgdglikly
       61 enfisefehr vnplslveii lhvvrqmtdp nvaltflekt rekvkssdea vilcktaiga
      121 lklnigdlqv tketiedvee mlnnlpgvts vhsrfydlss kyyqtignha syykdalrfl
      181 gcvdikdlpv seqqeraftl glagllgegv fnfgellmhp vleslrntdr qwlidtlyaf
      241 nsgnverfqt lktawgqqpd laaneaqllr kiqllclmei kgmkdrlefw ctdvksmeml
      301 vehqahdilt
//
LOCUS       XP_054225426            2065 aa            linear   PRI 05-AUG-2025
DEFINITION  cell adhesion molecule DSCAML1 isoform X1 [Homo sapiens].
ACCESSION   XP_054225426
VERSION     XP_054225426.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369451.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2065
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2065
                     /product="cell adhesion molecule DSCAML1 isoform X1"
                     /calculated_mol_wt=225511
     Region          27..122
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          43..47
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          56..60
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          80..84
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          100..105
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          113..117
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          130..218
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          142..146
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          158..162
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          180..184
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          195..200
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          211..214
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          245..323
                     /region_name="I-set"
                     /note="Immunoglobulin I-set domain; pfam07679"
                     /db_xref="CDD:400151"
     Region          255..259
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          268..272
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          303..308
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          317..320
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          326..415
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          344..348
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          357..361
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          381..385
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          395..400
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          408..411
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          419..514
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          437..441
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          450..454
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          480..484
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          494..499
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          507..510
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          517..605
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          534..538
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          547..551
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          569..573
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          584..589
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          598..601
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          608..698
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          625..629
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          639..643
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          664..668
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          678..683
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          691..694
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          701..797
                     /region_name="Ig_DSCAM"
                     /note="Immunoglobulin (Ig)-like domain of Down Syndrome
                     Cell Adhesion molecule (DSCAM); cd05734"
                     /db_xref="CDD:409397"
     Region          701..705
                     /region_name="putative Ig strand A"
                     /note="putative Ig strand A [structural motif]"
                     /db_xref="CDD:409397"
     Region          710..714
                     /region_name="putative Ig strand A'"
                     /note="putative Ig strand A' [structural motif]"
                     /db_xref="CDD:409397"
     Region          716..726
                     /region_name="putative Ig strand B"
                     /note="putative Ig strand B [structural motif]"
                     /db_xref="CDD:409397"
     Region          732..738
                     /region_name="putative Ig strand C"
                     /note="putative Ig strand C [structural motif]"
                     /db_xref="CDD:409397"
     Region          745..748
                     /region_name="putative Ig strand C'"
                     /note="putative Ig strand C' [structural motif]"
                     /db_xref="CDD:409397"
     Region          757..760
                     /region_name="putative Ig strand D"
                     /note="putative Ig strand D [structural motif]"
                     /db_xref="CDD:409397"
     Region          762..768
                     /region_name="putative Ig strand E"
                     /note="putative Ig strand E [structural motif]"
                     /db_xref="CDD:409397"
     Region          775..783
                     /region_name="putative Ig strand F"
                     /note="putative Ig strand F [structural motif]"
                     /db_xref="CDD:409397"
     Region          788..797
                     /region_name="putative Ig strand G"
                     /note="putative Ig strand G [structural motif]"
                     /db_xref="CDD:409397"
     Region          798..898
                     /region_name="Ig_DSCAM"
                     /note="Immunoglobulin (Ig) domain of Down Syndrome Cell
                     Adhesion molecule (DSCAM); cd05735"
                     /db_xref="CDD:409398"
     Region          798..801
                     /region_name="putative Ig strand A"
                     /note="putative Ig strand A [structural motif]"
                     /db_xref="CDD:409398"
     Region          809..813
                     /region_name="putative Ig strand A'"
                     /note="putative Ig strand A' [structural motif]"
                     /db_xref="CDD:409398"
     Region          816..823
                     /region_name="putative Ig strand B"
                     /note="putative Ig strand B [structural motif]"
                     /db_xref="CDD:409398"
     Region          831..837
                     /region_name="putative Ig strand C"
                     /note="putative Ig strand C [structural motif]"
                     /db_xref="CDD:409398"
     Region          847..850
                     /region_name="putative Ig strand C'"
                     /note="putative Ig strand C' [structural motif]"
                     /db_xref="CDD:409398"
     Region          856..860
                     /region_name="putative Ig strand D"
                     /note="putative Ig strand D [structural motif]"
                     /db_xref="CDD:409398"
     Region          862..868
                     /region_name="putative Ig strand E"
                     /note="putative Ig strand E [structural motif]"
                     /db_xref="CDD:409398"
     Region          875..883
                     /region_name="putative Ig strand F"
                     /note="putative Ig strand F [structural motif]"
                     /db_xref="CDD:409398"
     Region          886..896
                     /region_name="putative Ig strand G"
                     /note="putative Ig strand G [structural motif]"
                     /db_xref="CDD:409398"
     Region          <895..1208
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     Site            order(1203,1269,1284)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          <1223..1289
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(1285..1286,1288..1289)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1303..1379
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     Region          1396..1486
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(1396,1459,1474)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Site            order(1475..1476,1478..1479)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1500..1572
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     CDS             1..2065
                     /gene="DSCAML1"
                     /gene_synonym="DSCAM2"
                     /coded_by="XM_054369451.1:138..6335"
                     /db_xref="GeneID:57453"
                     /db_xref="HGNC:HGNC:14656"
                     /db_xref="MIM:611782"
ORIGIN      
        1 mwlvtfllll dslhkarped vgtslyfvnd slqqvtfsss vgvvvpcpaa gspsaalrwy
       61 latgddiydv phirhvhang tlqlypfsps afnsfihdnd yfctaenaag kirspnirvk
      121 avfrepytvr vedqrsmrgn vavfkclips svqeyvsvvs wekdtvsiip ehrffityhg
      181 glyisdvqke dalstyrcit khkysgetrq sngarlsvtg laraadplcl pdpaesipti
      241 ldgfhsqevw aghtvelpct asgypipair wlkdgrplpa dsrwtkritg ltisdlrted
      301 sgtyicevtn tfgsaeatgi lmvidplhvt ltpkklktgi gstvilscal tgspeftirw
      361 yrntelvlpd eaisirglsn etllitsaqk shsgayqcfa trkaqtaqdf aiialedgtp
      421 rivssfsekv vnpgeqfslm caakgapppt vtwalddepi vrdgshrtnq ytmsdgttis
      481 hmnvtgpqir dggvyrctar nlvgsaeyqa rinvrgppsi ramrnitava grdtlincrv
      541 igypyysikw ykdalllpdn hrqvvfengt lkltdvqkgm degeylcsvl iqpqlsisqs
      601 vhvavkvppl iqpfefppas igqllyipcv vssgdmpiri twrkdgqvii sgsgvtiesk
      661 efmsslqiss vslkhngnyt ciasnaaatv srerqlivrv pprfvvqpnn qdgiygkagv
      721 lncsvdgypp pkvmwkhakg sgnpqqyhpv pltgriqilp nssllirhvl eedigyylcq
      781 asngvgtdis ksmfltvkip amitshpntt iaikghakel nctargerpi iirwekgdtv
      841 idpdrvmrya iatkdngdev vstlklkpad rgdsvffsch ainsygedrg liqltvqepp
      901 dppeleirev karsmnlrwt qrfdgnsiit gfdieyknks dswdfkqstr nisptinqan
      961 ivdlhpasvy sirmysfnki grsepskelt isteeaapdg ppmdvtlqpv tsqsiqvtwk
     1021 apkkelqngv irgyqigyre nspgsngqys ivemkatgds evytldnlkk faqygvvvqa
     1081 fnragtgpss seinattled vpsqppenvr alsitsdvav iswsepprst lngvlkgyrv
     1141 ifwslyvdge wgemqnittt rervelrgme kftnysvqvl aytqagdgvr ssvlyiqtke
     1201 dvpgppagik avpssassvv vswlpptkpn gvirkytifc sspgsgqpap seyetspeql
     1261 fyriahlnrg qqyllwvaav tsagrgnsse kvtiepagka pakiisfggt vttpwmkdvr
     1321 lpcnsvgdpa pavkwtkdse dsaipvsmdg hrlihtngtl llravkaeds gyytctatnt
     1381 ggfdtiivnl lvqvppdqpr ltvsktsass itltwipgdn ggssirgfvl qysvdnseew
     1441 kdvfissser sfkldslkcg twykvklaak nsvgsgrise iieakthgre psfskdqhlf
     1501 thinstharl nlqgwnnggc pitaivleyr pkgtwawqgl ranssgevfl telreatwye
     1561 lrmracnsag cgnetaqfat ldydgstipp iksaqgegdd vkklftigcp vilatlgval
     1621 lfivrkkrke krlkrlrdak slaemliskn nrsfdtpvkg ppqgprlhid iprvqllied
     1681 kegikqlgdd katipvtdae fsqavnpqsf ctgvslhhpt liqstgplid msdirpgtnp
     1741 vsrknvksah strnryssqw tltkcqastp artltsdwrt vgsqhgvtvt esdsysasls
     1801 qdtdkgrnsm vstesassty eelarayeha kleeqlqhak feitecfisd sssdqmttgt
     1861 nenadsmtsm stpsepgicr ftasppkpqd adrgknvavp iphranksdy cnlplyakse
     1921 affrkadgre pcpvvpprea sirnlartyh tqarhltldp askslglphp gapaaastat
     1981 lpqrtlampa ppagtappap gptpaeppta psaappapst eppraggpht kmggsrdsll
     2041 emstsgvgrs qkqgagaysk sytlv
//
LOCUS       XP_054225427            1977 aa            linear   PRI 05-AUG-2025
DEFINITION  cell adhesion molecule DSCAML1 isoform X2 [Homo sapiens].
ACCESSION   XP_054225427
VERSION     XP_054225427.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369452.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 1% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1977
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1977
                     /product="cell adhesion molecule DSCAML1 isoform X2"
                     /calculated_mol_wt=215858
     Region          42..130
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          54..58
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          70..74
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          92..96
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          107..112
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          123..126
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          157..235
                     /region_name="I-set"
                     /note="Immunoglobulin I-set domain; pfam07679"
                     /db_xref="CDD:400151"
     Region          167..171
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          180..184
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          215..220
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          229..232
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          238..327
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          256..260
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          269..273
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          293..297
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          307..312
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          320..323
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          331..426
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          349..353
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          362..366
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          392..396
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          406..411
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          419..422
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          429..517
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          446..450
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          459..463
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          481..485
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          496..501
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          510..513
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          520..610
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          537..541
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          551..555
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          576..580
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          590..595
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          603..606
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          613..709
                     /region_name="Ig_DSCAM"
                     /note="Immunoglobulin (Ig)-like domain of Down Syndrome
                     Cell Adhesion molecule (DSCAM); cd05734"
                     /db_xref="CDD:409397"
     Region          613..617
                     /region_name="putative Ig strand A"
                     /note="putative Ig strand A [structural motif]"
                     /db_xref="CDD:409397"
     Region          622..626
                     /region_name="putative Ig strand A'"
                     /note="putative Ig strand A' [structural motif]"
                     /db_xref="CDD:409397"
     Region          628..638
                     /region_name="putative Ig strand B"
                     /note="putative Ig strand B [structural motif]"
                     /db_xref="CDD:409397"
     Region          644..650
                     /region_name="putative Ig strand C"
                     /note="putative Ig strand C [structural motif]"
                     /db_xref="CDD:409397"
     Region          657..660
                     /region_name="putative Ig strand C'"
                     /note="putative Ig strand C' [structural motif]"
                     /db_xref="CDD:409397"
     Region          669..672
                     /region_name="putative Ig strand D"
                     /note="putative Ig strand D [structural motif]"
                     /db_xref="CDD:409397"
     Region          674..680
                     /region_name="putative Ig strand E"
                     /note="putative Ig strand E [structural motif]"
                     /db_xref="CDD:409397"
     Region          687..695
                     /region_name="putative Ig strand F"
                     /note="putative Ig strand F [structural motif]"
                     /db_xref="CDD:409397"
     Region          700..709
                     /region_name="putative Ig strand G"
                     /note="putative Ig strand G [structural motif]"
                     /db_xref="CDD:409397"
     Region          710..810
                     /region_name="Ig_DSCAM"
                     /note="Immunoglobulin (Ig) domain of Down Syndrome Cell
                     Adhesion molecule (DSCAM); cd05735"
                     /db_xref="CDD:409398"
     Region          710..713
                     /region_name="putative Ig strand A"
                     /note="putative Ig strand A [structural motif]"
                     /db_xref="CDD:409398"
     Region          721..725
                     /region_name="putative Ig strand A'"
                     /note="putative Ig strand A' [structural motif]"
                     /db_xref="CDD:409398"
     Region          728..735
                     /region_name="putative Ig strand B"
                     /note="putative Ig strand B [structural motif]"
                     /db_xref="CDD:409398"
     Region          743..749
                     /region_name="putative Ig strand C"
                     /note="putative Ig strand C [structural motif]"
                     /db_xref="CDD:409398"
     Region          759..762
                     /region_name="putative Ig strand C'"
                     /note="putative Ig strand C' [structural motif]"
                     /db_xref="CDD:409398"
     Region          768..772
                     /region_name="putative Ig strand D"
                     /note="putative Ig strand D [structural motif]"
                     /db_xref="CDD:409398"
     Region          774..780
                     /region_name="putative Ig strand E"
                     /note="putative Ig strand E [structural motif]"
                     /db_xref="CDD:409398"
     Region          787..795
                     /region_name="putative Ig strand F"
                     /note="putative Ig strand F [structural motif]"
                     /db_xref="CDD:409398"
     Region          798..808
                     /region_name="putative Ig strand G"
                     /note="putative Ig strand G [structural motif]"
                     /db_xref="CDD:409398"
     Region          <807..1120
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     Site            order(1115,1181,1196)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          <1135..1201
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(1197..1198,1200..1201)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1215..1291
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     Region          1308..1398
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(1308,1371,1386)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Site            order(1387..1388,1390..1391)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1412..1484
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     CDS             1..1977
                     /gene="DSCAML1"
                     /gene_synonym="DSCAM2"
                     /coded_by="XM_054369452.1:223..6156"
                     /db_xref="GeneID:57453"
                     /db_xref="HGNC:HGNC:14656"
                     /db_xref="MIM:611782"
ORIGIN      
        1 mtpcssfihd ndyfctaena agkirspnir vkavfrepyt vrvedqrsmr gnvavfkcli
       61 pssvqeyvsv vswekdtvsi ipehrffity hgglyisdvq kedalstyrc itkhkysget
      121 rqsngarlsv tglaraadpl clpdpaesip tildgfhsqe vwaghtvelp ctasgypipa
      181 irwlkdgrpl padsrwtkri tgltisdlrt edsgtyicev tntfgsaeat gilmvidplh
      241 vtltpkklkt gigstvilsc altgspefti rwyrntelvl pdeaisirgl snetllitsa
      301 qkshsgayqc fatrkaqtaq dfaiialedg tprivssfse kvvnpgeqfs lmcaakgapp
      361 ptvtwaldde pivrdgshrt nqytmsdgtt ishmnvtgpq irdggvyrct arnlvgsaey
      421 qarinvrgpp siramrnita vagrdtlinc rvigypyysi kwykdalllp dnhrqvvfen
      481 gtlkltdvqk gmdegeylcs vliqpqlsis qsvhvavkvp pliqpfefpp asigqllyip
      541 cvvssgdmpi ritwrkdgqv iisgsgvtie skefmsslqi ssvslkhngn ytciasnaaa
      601 tvsrerqliv rvpprfvvqp nnqdgiygka gvlncsvdgy pppkvmwkha kgsgnpqqyh
      661 pvpltgriqi lpnssllirh vleedigyyl cqasngvgtd isksmfltvk ipamitshpn
      721 ttiaikghak elnctarger piiirwekgd tvidpdrvmr yaiatkdngd evvstlklkp
      781 adrgdsvffs chainsyged rgliqltvqe ppdppeleir evkarsmnlr wtqrfdgnsi
      841 itgfdieykn ksdswdfkqs trnisptinq anivdlhpas vysirmysfn kigrsepske
      901 ltisteeaap dgppmdvtlq pvtsqsiqvt wkapkkelqn gvirgyqigy renspgsngq
      961 ysivemkatg dsevytldnl kkfaqygvvv qafnragtgp ssseinattl edvpsqppen
     1021 vralsitsdv aviswseppr stlngvlkgy rvifwslyvd gewgemqnit ttrervelrg
     1081 mekftnysvq vlaytqagdg vrssvlyiqt kedvpgppag ikavpssass vvvswlpptk
     1141 pngvirkyti fcsspgsgqp apseyetspe qlfyriahln rgqqyllwva avtsagrgns
     1201 sekvtiepag kapakiisfg gtvttpwmkd vrlpcnsvgd papavkwtkd sedsaipvsm
     1261 dghrlihtng tlllravkae dsgyytctat ntggfdtiiv nllvqvppdq prltvsktsa
     1321 ssitltwipg dnggssirgf vlqysvdnse ewkdvfisss ersfkldslk cgtwykvkla
     1381 aknsvgsgri seiieakthg repsfskdqh lfthinstha rlnlqgwnng gcpitaivle
     1441 yrpkgtwawq glranssgev fltelreatw yelrmracns agcgnetaqf atldydgsti
     1501 ppiksaqgeg ddvkklftig cpvilatlgv allfivrkkr kekrlkrlrd akslaemlis
     1561 knnrsfdtpv kgppqgprlh idiprvqlli edkegikqlg ddkatipvtd aefsqavnpq
     1621 sfctgvslhh ptliqstgpl idmsdirpgt npvsrknvks ahstrnryss qwtltkcqas
     1681 tpartltsdw rtvgsqhgvt vtesdsysas lsqdtdkgrn smvstesass tyeelaraye
     1741 hakleeqlqh akfeitecfi sdsssdqmtt gtnenadsmt smstpsepgi crftasppkp
     1801 qdadrgknva vpiphranks dycnlplyak seaffrkadg repcpvvppr easirnlart
     1861 yhtqarhltl dpaskslglp hpgapaaast atlpqrtlam pappagtapp apgptpaepp
     1921 tapsaappap steppraggp htkmggsrds llemstsgvg rsqkqgagay sksytlv
//
LOCUS       XP_054225428            1626 aa            linear   PRI 05-AUG-2025
DEFINITION  cell adhesion molecule DSCAML1 isoform X3 [Homo sapiens].
ACCESSION   XP_054225428
VERSION     XP_054225428.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369453.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1626
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1626
                     /product="cell adhesion molecule DSCAML1 isoform X3"
                     /calculated_mol_wt=177189
     Region          <2..75
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          11..15
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          41..45
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          55..60
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          68..71
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          78..166
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          95..99
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          108..112
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          130..134
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          145..150
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          159..162
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          169..259
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          186..190
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          200..204
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          225..229
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          239..244
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          252..255
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          262..358
                     /region_name="Ig_DSCAM"
                     /note="Immunoglobulin (Ig)-like domain of Down Syndrome
                     Cell Adhesion molecule (DSCAM); cd05734"
                     /db_xref="CDD:409397"
     Region          262..266
                     /region_name="putative Ig strand A"
                     /note="putative Ig strand A [structural motif]"
                     /db_xref="CDD:409397"
     Region          271..275
                     /region_name="putative Ig strand A'"
                     /note="putative Ig strand A' [structural motif]"
                     /db_xref="CDD:409397"
     Region          277..287
                     /region_name="putative Ig strand B"
                     /note="putative Ig strand B [structural motif]"
                     /db_xref="CDD:409397"
     Region          293..299
                     /region_name="putative Ig strand C"
                     /note="putative Ig strand C [structural motif]"
                     /db_xref="CDD:409397"
     Region          306..309
                     /region_name="putative Ig strand C'"
                     /note="putative Ig strand C' [structural motif]"
                     /db_xref="CDD:409397"
     Region          318..321
                     /region_name="putative Ig strand D"
                     /note="putative Ig strand D [structural motif]"
                     /db_xref="CDD:409397"
     Region          323..329
                     /region_name="putative Ig strand E"
                     /note="putative Ig strand E [structural motif]"
                     /db_xref="CDD:409397"
     Region          336..344
                     /region_name="putative Ig strand F"
                     /note="putative Ig strand F [structural motif]"
                     /db_xref="CDD:409397"
     Region          349..358
                     /region_name="putative Ig strand G"
                     /note="putative Ig strand G [structural motif]"
                     /db_xref="CDD:409397"
     Region          359..459
                     /region_name="Ig_DSCAM"
                     /note="Immunoglobulin (Ig) domain of Down Syndrome Cell
                     Adhesion molecule (DSCAM); cd05735"
                     /db_xref="CDD:409398"
     Region          359..362
                     /region_name="putative Ig strand A"
                     /note="putative Ig strand A [structural motif]"
                     /db_xref="CDD:409398"
     Region          370..374
                     /region_name="putative Ig strand A'"
                     /note="putative Ig strand A' [structural motif]"
                     /db_xref="CDD:409398"
     Region          377..384
                     /region_name="putative Ig strand B"
                     /note="putative Ig strand B [structural motif]"
                     /db_xref="CDD:409398"
     Region          392..398
                     /region_name="putative Ig strand C"
                     /note="putative Ig strand C [structural motif]"
                     /db_xref="CDD:409398"
     Region          408..411
                     /region_name="putative Ig strand C'"
                     /note="putative Ig strand C' [structural motif]"
                     /db_xref="CDD:409398"
     Region          417..421
                     /region_name="putative Ig strand D"
                     /note="putative Ig strand D [structural motif]"
                     /db_xref="CDD:409398"
     Region          423..429
                     /region_name="putative Ig strand E"
                     /note="putative Ig strand E [structural motif]"
                     /db_xref="CDD:409398"
     Region          436..444
                     /region_name="putative Ig strand F"
                     /note="putative Ig strand F [structural motif]"
                     /db_xref="CDD:409398"
     Region          447..457
                     /region_name="putative Ig strand G"
                     /note="putative Ig strand G [structural motif]"
                     /db_xref="CDD:409398"
     Region          <456..769
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     Site            order(764,830,845)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          <784..850
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(846..847,849..850)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          864..940
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     Region          957..1047
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(957,1020,1035)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Site            order(1036..1037,1039..1040)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1061..1133
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     CDS             1..1626
                     /gene="DSCAML1"
                     /gene_synonym="DSCAM2"
                     /coded_by="XM_054369453.1:137..5017"
                     /db_xref="GeneID:57453"
                     /db_xref="HGNC:HGNC:14656"
                     /db_xref="MIM:611782"
ORIGIN      
        1 mcaakgappp tvtwalddep ivrdgshrtn qytmsdgtti shmnvtgpqi rdggvyrcta
       61 rnlvgsaeyq arinvrgpps iramrnitav agrdtlincr vigypyysik wykdalllpd
      121 nhrqvvfeng tlkltdvqkg mdegeylcsv liqpqlsisq svhvavkvpp liqpfefppa
      181 sigqllyipc vvssgdmpir itwrkdgqvi isgsgvties kefmsslqis svslkhngny
      241 tciasnaaat vsrerqlivr vpprfvvqpn nqdgiygkag vlncsvdgyp ppkvmwkhak
      301 gsgnpqqyhp vpltgriqil pnssllirhv leedigyylc qasngvgtdi sksmfltvki
      361 pamitshpnt tiaikghake lnctargerp iiirwekgdt vidpdrvmry aiatkdngde
      421 vvstlklkpa drgdsvffsc hainsygedr gliqltvqep pdppeleire vkarsmnlrw
      481 tqrfdgnsii tgfdieyknk sdswdfkqst rnisptinqa nivdlhpasv ysirmysfnk
      541 igrsepskel tisteeaapd gppmdvtlqp vtsqsiqvtw kapkkelqng virgyqigyr
      601 enspgsngqy sivemkatgd sevytldnlk kfaqygvvvq afnragtgps sseinattle
      661 dvpsqppenv ralsitsdva viswsepprs tlngvlkgyr vifwslyvdg ewgemqnitt
      721 trervelrgm ekftnysvqv laytqagdgv rssvlyiqtk edvpgppagi kavpssassv
      781 vvswlpptkp ngvirkytif csspgsgqpa pseyetspeq lfyriahlnr gqqyllwvaa
      841 vtsagrgnss ekvtiepagk apakiisfgg tvttpwmkdv rlpcnsvgdp apavkwtkds
      901 edsaipvsmd ghrlihtngt lllravkaed sgyytctatn tggfdtiivn llvqvppdqp
      961 rltvsktsas sitltwipgd nggssirgfv lqysvdnsee wkdvfissse rsfkldslkc
     1021 gtwykvklaa knsvgsgris eiieakthgr epsfskdqhl fthinsthar lnlqgwnngg
     1081 cpitaivley rpkgtwawqg lranssgevf ltelreatwy elrmracnsa gcgnetaqfa
     1141 tldydgstip piksaqgegd dvkklftigc pvilatlgva llfivrkkrk ekrlkrlrda
     1201 kslaemlisk nnrsfdtpvk gppqgprlhi diprvqllie dkegikqlgd dkatipvtda
     1261 efsqavnpqs fctgvslhhp tliqstgpli dmsdirpgtn pvsrknvksa hstrnryssq
     1321 wtltkcqast partltsdwr tvgsqhgvtv tesdsysasl sqdtdkgrns mvstesasst
     1381 yeelarayeh akleeqlqha kfeitecfis dsssdqmttg tnenadsmts mstpsepgic
     1441 rftasppkpq dadrgknvav piphranksd ycnlplyaks eaffrkadgr epcpvvppre
     1501 asirnlarty htqarhltld paskslglph pgapaaasta tlpqrtlamp appagtappa
     1561 pgptpaeppt apsaappaps teppraggph tkmggsrdsl lemstsgvgr sqkqgagays
     1621 ksytlv
//
LOCUS       XP_054225429            1344 aa            linear   PRI 05-AUG-2025
DEFINITION  cell adhesion molecule DSCAML1 isoform X4 [Homo sapiens].
ACCESSION   XP_054225429
VERSION     XP_054225429.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369454.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1344
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1344
                     /product="cell adhesion molecule DSCAML1 isoform X4"
                     /calculated_mol_wt=146211
     Region          78..177
                     /region_name="Ig_DSCAM"
                     /note="Immunoglobulin (Ig) domain of Down Syndrome Cell
                     Adhesion molecule (DSCAM); cd05735"
                     /db_xref="CDD:409398"
     Region          88..92
                     /region_name="putative Ig strand A'"
                     /note="putative Ig strand A' [structural motif]"
                     /db_xref="CDD:409398"
     Region          95..102
                     /region_name="putative Ig strand B"
                     /note="putative Ig strand B [structural motif]"
                     /db_xref="CDD:409398"
     Region          110..116
                     /region_name="putative Ig strand C"
                     /note="putative Ig strand C [structural motif]"
                     /db_xref="CDD:409398"
     Region          126..129
                     /region_name="putative Ig strand C'"
                     /note="putative Ig strand C' [structural motif]"
                     /db_xref="CDD:409398"
     Region          135..139
                     /region_name="putative Ig strand D"
                     /note="putative Ig strand D [structural motif]"
                     /db_xref="CDD:409398"
     Region          141..147
                     /region_name="putative Ig strand E"
                     /note="putative Ig strand E [structural motif]"
                     /db_xref="CDD:409398"
     Region          154..162
                     /region_name="putative Ig strand F"
                     /note="putative Ig strand F [structural motif]"
                     /db_xref="CDD:409398"
     Region          165..175
                     /region_name="putative Ig strand G"
                     /note="putative Ig strand G [structural motif]"
                     /db_xref="CDD:409398"
     Region          <174..487
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     Site            order(482,548,563)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          <502..568
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(564..565,567..568)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          582..658
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     Region          675..765
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(675,738,753)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Site            order(754..755,757..758)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          779..851
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     CDS             1..1344
                     /gene="DSCAML1"
                     /gene_synonym="DSCAM2"
                     /coded_by="XM_054369454.1:587..4621"
                     /db_xref="GeneID:57453"
                     /db_xref="HGNC:HGNC:14656"
                     /db_xref="MIM:611782"
ORIGIN      
        1 mdyafpdapq sklmspnplm khssdfppvh vagaatecsn sspvtvtsrn pricshhitv
       61 ianiskyhly aallqdhvpa mitshpntti aikghakeln ctargerpii irwekgdtvi
      121 dpdrvmryai atkdngdevv stlklkpadr gdsvffscha insygedrgl iqltvqeppd
      181 ppeleirevk arsmnlrwtq rfdgnsiitg fdieyknksd swdfkqstrn isptinqani
      241 vdlhpasvys irmysfnkig rsepskelti steeaapdgp pmdvtlqpvt sqsiqvtwka
      301 pkkelqngvi rgyqigyren spgsngqysi vemkatgdse vytldnlkkf aqygvvvqaf
      361 nragtgpsss einattledv psqppenvra lsitsdvavi swsepprstl ngvlkgyrvi
      421 fwslyvdgew gemqnitttr ervelrgmek ftnysvqvla ytqagdgvrs svlyiqtked
      481 vpgppagika vpssassvvv swlpptkpng virkytifcs spgsgqpaps eyetspeqlf
      541 yriahlnrgq qyllwvaavt sagrgnssek vtiepagkap akiisfggtv ttpwmkdvrl
      601 pcnsvgdpap avkwtkdsed saipvsmdgh rlihtngtll lravkaedsg yytctatntg
      661 gfdtiivnll vqvppdqprl tvsktsassi tltwipgdng gssirgfvlq ysvdnseewk
      721 dvfisssers fkldslkcgt wykvklaakn svgsgrisei ieakthgrep sfskdqhlft
      781 hinstharln lqgwnnggcp itaivleyrp kgtwawqglr anssgevflt elreatwyel
      841 rmracnsagc gnetaqfatl dydgstippi ksaqgegddv kklftigcpv ilatlgvall
      901 fivrkkrkek rlkrlrdaks laemlisknn rsfdtpvkgp pqgprlhidi prvqlliedk
      961 egikqlgddk atipvtdaef sqavnpqsfc tgvslhhptl iqstgplidm sdirpgtnpv
     1021 srknvksahs trnryssqwt ltkcqastpa rtltsdwrtv gsqhgvtvte sdsysaslsq
     1081 dtdkgrnsmv stesasstye elarayehak leeqlqhakf eitecfisds ssdqmttgtn
     1141 enadsmtsms tpsepgicrf tasppkpqda drgknvavpi phranksdyc nlplyaksea
     1201 ffrkadgrep cpvvppreas irnlartyht qarhltldpa skslglphpg apaaastatl
     1261 pqrtlampap pagtappapg ptpaepptap saappapste ppraggphtk mggsrdslle
     1321 mstsgvgrsq kqgagaysks ytlv
//
LOCUS       XP_054225430            1270 aa            linear   PRI 05-AUG-2025
DEFINITION  cell adhesion molecule DSCAML1 isoform X5 [Homo sapiens].
ACCESSION   XP_054225430
VERSION     XP_054225430.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369455.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1270
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1270
                     /product="cell adhesion molecule DSCAML1 isoform X5"
                     /calculated_mol_wt=138161
     Region          4..103
                     /region_name="Ig_DSCAM"
                     /note="Immunoglobulin (Ig) domain of Down Syndrome Cell
                     Adhesion molecule (DSCAM); cd05735"
                     /db_xref="CDD:409398"
     Region          14..18
                     /region_name="putative Ig strand A'"
                     /note="putative Ig strand A' [structural motif]"
                     /db_xref="CDD:409398"
     Region          21..28
                     /region_name="putative Ig strand B"
                     /note="putative Ig strand B [structural motif]"
                     /db_xref="CDD:409398"
     Region          36..42
                     /region_name="putative Ig strand C"
                     /note="putative Ig strand C [structural motif]"
                     /db_xref="CDD:409398"
     Region          52..55
                     /region_name="putative Ig strand C'"
                     /note="putative Ig strand C' [structural motif]"
                     /db_xref="CDD:409398"
     Region          61..65
                     /region_name="putative Ig strand D"
                     /note="putative Ig strand D [structural motif]"
                     /db_xref="CDD:409398"
     Region          67..73
                     /region_name="putative Ig strand E"
                     /note="putative Ig strand E [structural motif]"
                     /db_xref="CDD:409398"
     Region          80..88
                     /region_name="putative Ig strand F"
                     /note="putative Ig strand F [structural motif]"
                     /db_xref="CDD:409398"
     Region          91..101
                     /region_name="putative Ig strand G"
                     /note="putative Ig strand G [structural motif]"
                     /db_xref="CDD:409398"
     Region          <100..413
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     Region          205..302
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(291..292,294..295)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Site            order(408,474,489)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          <428..494
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(490..491,493..494)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          508..584
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     Region          601..691
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(601,664,679)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Site            order(680..681,683..684)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          705..777
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     CDS             1..1270
                     /gene="DSCAML1"
                     /gene_synonym="DSCAM2"
                     /coded_by="XM_054369455.1:696..4508"
                     /db_xref="GeneID:57453"
                     /db_xref="HGNC:HGNC:14656"
                     /db_xref="MIM:611782"
ORIGIN      
        1 mesvpamits hpnttiaikg hakelnctar gerpiiirwe kgdtvidpdr vmryaiatkd
       61 ngdevvstlk lkpadrgdsv ffschainsy gedrgliqlt vqeppdppel eirevkarsm
      121 nlrwtqrfdg nsiitgfdie yknksdswdf kqstrnispt inqanivdlh pasvysirmy
      181 sfnkigrsep skeltistee aapdgppmdv tlqpvtsqsi qvtwkapkke lqngvirgyq
      241 igyrenspgs ngqysivemk atgdsevytl dnlkkfaqyg vvvqafnrag tgpssseina
      301 ttledvpsqp penvralsit sdvaviswse pprstlngvl kgyrvifwsl yvdgewgemq
      361 nitttrerve lrgmekftny svqvlaytqa gdgvrssvly iqtkedvpgp pagikavpss
      421 assvvvswlp ptkpngvirk ytifcsspgs gqpapseyet speqlfyria hlnrgqqyll
      481 wvaavtsagr gnssekvtie pagkapakii sfggtvttpw mkdvrlpcns vgdpapavkw
      541 tkdsedsaip vsmdghrlih tngtlllrav kaedsgyytc tatntggfdt iivnllvqvp
      601 pdqprltvsk tsassitltw ipgdnggssi rgfvlqysvd nseewkdvfi sssersfkld
      661 slkcgtwykv klaaknsvgs griseiieak thgrepsfsk dqhlfthins tharlnlqgw
      721 nnggcpitai vleyrpkgtw awqglranss gevfltelre atwyelrmra cnsagcgnet
      781 aqfatldydg stippiksaq gegddvkklf tigcpvilat lgvallfivr kkrkekrlkr
      841 lrdakslaem lisknnrsfd tpvkgppqgp rlhidiprvq lliedkegik qlgddkatip
      901 vtdaefsqav npqsfctgvs lhhptliqst gplidmsdir pgtnpvsrkn vksahstrnr
      961 yssqwtltkc qastpartlt sdwrtvgsqh gvtvtesdsy saslsqdtdk grnsmvstes
     1021 asstyeelar ayehakleeq lqhakfeite cfisdsssdq mttgtnenad smtsmstpse
     1081 pgicrftasp pkpqdadrgk nvavpiphra nksdycnlpl yakseaffrk adgrepcpvv
     1141 ppreasirnl artyhtqarh ltldpasksl glphpgapaa astatlpqrt lampappagt
     1201 appapgptpa epptapsaap papsteppra ggphtkmggs rdsllemsts gvgrsqkqga
     1261 gaysksytlv
//
LOCUS       XP_054225431            1264 aa            linear   PRI 05-AUG-2025
DEFINITION  cell adhesion molecule DSCAML1 isoform X6 [Homo sapiens].
ACCESSION   XP_054225431
VERSION     XP_054225431.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369456.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1264
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1264
                     /product="cell adhesion molecule DSCAML1 isoform X6"
                     /calculated_mol_wt=137546
     Region          1..97
                     /region_name="Ig_DSCAM"
                     /note="Immunoglobulin (Ig) domain of Down Syndrome Cell
                     Adhesion molecule (DSCAM); cd05735"
                     /db_xref="CDD:409398"
     Region          8..12
                     /region_name="putative Ig strand A'"
                     /note="putative Ig strand A' [structural motif]"
                     /db_xref="CDD:409398"
     Region          15..22
                     /region_name="putative Ig strand B"
                     /note="putative Ig strand B [structural motif]"
                     /db_xref="CDD:409398"
     Region          30..36
                     /region_name="putative Ig strand C"
                     /note="putative Ig strand C [structural motif]"
                     /db_xref="CDD:409398"
     Region          46..49
                     /region_name="putative Ig strand C'"
                     /note="putative Ig strand C' [structural motif]"
                     /db_xref="CDD:409398"
     Region          55..59
                     /region_name="putative Ig strand D"
                     /note="putative Ig strand D [structural motif]"
                     /db_xref="CDD:409398"
     Region          61..67
                     /region_name="putative Ig strand E"
                     /note="putative Ig strand E [structural motif]"
                     /db_xref="CDD:409398"
     Region          74..82
                     /region_name="putative Ig strand F"
                     /note="putative Ig strand F [structural motif]"
                     /db_xref="CDD:409398"
     Region          85..95
                     /region_name="putative Ig strand G"
                     /note="putative Ig strand G [structural motif]"
                     /db_xref="CDD:409398"
     Region          <94..407
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     Region          199..296
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(285..286,288..289)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Site            order(402,468,483)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          <422..488
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(484..485,487..488)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          502..578
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     Region          595..685
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(595,658,673)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Site            order(674..675,677..678)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          699..771
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     CDS             1..1264
                     /gene="DSCAML1"
                     /gene_synonym="DSCAM2"
                     /coded_by="XM_054369456.1:1419..5213"
                     /db_xref="GeneID:57453"
                     /db_xref="HGNC:HGNC:14656"
                     /db_xref="MIM:611782"
ORIGIN      
        1 mitshpntti aikghakeln ctargerpii irwekgdtvi dpdrvmryai atkdngdevv
       61 stlklkpadr gdsvffscha insygedrgl iqltvqeppd ppeleirevk arsmnlrwtq
      121 rfdgnsiitg fdieyknksd swdfkqstrn isptinqani vdlhpasvys irmysfnkig
      181 rsepskelti steeaapdgp pmdvtlqpvt sqsiqvtwka pkkelqngvi rgyqigyren
      241 spgsngqysi vemkatgdse vytldnlkkf aqygvvvqaf nragtgpsss einattledv
      301 psqppenvra lsitsdvavi swsepprstl ngvlkgyrvi fwslyvdgew gemqnitttr
      361 ervelrgmek ftnysvqvla ytqagdgvrs svlyiqtked vpgppagika vpssassvvv
      421 swlpptkpng virkytifcs spgsgqpaps eyetspeqlf yriahlnrgq qyllwvaavt
      481 sagrgnssek vtiepagkap akiisfggtv ttpwmkdvrl pcnsvgdpap avkwtkdsed
      541 saipvsmdgh rlihtngtll lravkaedsg yytctatntg gfdtiivnll vqvppdqprl
      601 tvsktsassi tltwipgdng gssirgfvlq ysvdnseewk dvfisssers fkldslkcgt
      661 wykvklaakn svgsgrisei ieakthgrep sfskdqhlft hinstharln lqgwnnggcp
      721 itaivleyrp kgtwawqglr anssgevflt elreatwyel rmracnsagc gnetaqfatl
      781 dydgstippi ksaqgegddv kklftigcpv ilatlgvall fivrkkrkek rlkrlrdaks
      841 laemlisknn rsfdtpvkgp pqgprlhidi prvqlliedk egikqlgddk atipvtdaef
      901 sqavnpqsfc tgvslhhptl iqstgplidm sdirpgtnpv srknvksahs trnryssqwt
      961 ltkcqastpa rtltsdwrtv gsqhgvtvte sdsysaslsq dtdkgrnsmv stesasstye
     1021 elarayehak leeqlqhakf eitecfisds ssdqmttgtn enadsmtsms tpsepgicrf
     1081 tasppkpqda drgknvavpi phranksdyc nlplyaksea ffrkadgrep cpvvppreas
     1141 irnlartyht qarhltldpa skslglphpg apaaastatl pqrtlampap pagtappapg
     1201 ptpaepptap saappapste ppraggphtk mggsrdslle mstsgvgrsq kqgagaysks
     1261 ytlv
//
LOCUS       XP_054225432             896 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Aster-B isoform X1 [Homo sapiens].
ACCESSION   XP_054225432
VERSION     XP_054225432.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369457.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 10% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..896
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..896
                     /product="protein Aster-B isoform X1"
                     /calculated_mol_wt=102933
     Region          250..343
                     /region_name="PH-GRAM_GRAMDC"
                     /note="GRAM domain-containing protein (GRAMDC) Pleckstrin
                     Homology-Glucosyltransferases, Rab-like GTPase activators
                     and Myotubularins (PH-GRAM) domain; cd13220"
                     /db_xref="CDD:275406"
     Region          520..666
                     /region_name="VASt"
                     /note="VAD1 Analog of StAR-related lipid transfer domain;
                     pfam16016"
                     /db_xref="CDD:464975"
     CDS             1..896
                     /gene="GRAMD1B"
                     /gene_synonym="LINC01059"
                     /coded_by="XM_054369457.1:830..3520"
                     /db_xref="GeneID:57476"
                     /db_xref="HGNC:HGNC:29214"
                     /db_xref="MIM:620179"
ORIGIN      
        1 mpaanmmenr plpalqvpep qgapegspvw sssstptlrr rrfkmrrmkn vqeqsleagl
       61 ardlpavlap gkeflqlpsi eitpssdedt pwsncstpsa sprrkrfllr kwlrvrerke
      121 csesssqqss qqsshdddss rflspraree stasnsnrst pacspilrkr srsptpqnqd
      181 gdtmvekgsd hssdkspstp eqgvqrscss qsgrsggkns kksqswynvl sptykqrned
      241 frklfkqlpd terlivdysc alqrdillqg rlylsenwic fysnifrwet lltvrlkdic
      301 smtkektarl ipnaiqvctd sekhfftsfg ardrtymmmf rlwqnallek plcpkelwhf
      361 vhqcygnelg ltsddedyvp pdddfntmgy ceeipveene vndssskssi etkpdaspql
      421 pkksitnstl tstgsseapv sfdglpleee alegdgslek elaidnimge kiemiapvns
      481 psldfndned iptelsdssd thdegevqaf yedlsgrqyv nevfnfsvdk lydllftnsp
      541 fqrdfmeqrr fsdiifhpwk keengnqsrv ilytitltnp lapktatvre tqtmykasqe
      601 secyvidaev lthdvpyhdy fytinrytlt rvarnksrlr vstelryrkq pwglvktfie
      661 knfwsgledy frhleselak testylaemh rqspkekask tttvrrrkrp hahlrvphle
      721 evmspvttpt dedvghrikh vagstqtrhi pedtpngfhl qsvsklllvi scvlvllvil
      781 nmmlfyklwm leyttqtlta wqglrlqerl pqsqtewaql lesqqkyhdt elqkwreiik
      841 ssvmlldqvr cptfsacpgl wergllplcc ekdprlyhhp pdfslqfilp pghalf
//
LOCUS       XP_054225433             881 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Aster-B isoform X2 [Homo sapiens].
ACCESSION   XP_054225433
VERSION     XP_054225433.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369458.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..881
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..881
                     /product="protein Aster-B isoform X2"
                     /calculated_mol_wt=101299
     Region          235..328
                     /region_name="PH-GRAM_GRAMDC"
                     /note="GRAM domain-containing protein (GRAMDC) Pleckstrin
                     Homology-Glucosyltransferases, Rab-like GTPase activators
                     and Myotubularins (PH-GRAM) domain; cd13220"
                     /db_xref="CDD:275406"
     Region          505..651
                     /region_name="VASt"
                     /note="VAD1 Analog of StAR-related lipid transfer domain;
                     pfam16016"
                     /db_xref="CDD:464975"
     CDS             1..881
                     /gene="GRAMD1B"
                     /gene_synonym="LINC01059"
                     /coded_by="XM_054369458.1:115..2760"
                     /db_xref="GeneID:57476"
                     /db_xref="HGNC:HGNC:29214"
                     /db_xref="MIM:620179"
ORIGIN      
        1 mvpepqgape gspvwsssst ptlrrrrfkm rrmknvqeqs leaglardlp avlapgkefl
       61 qlpsieitps sdedtpwsnc stpsasprrk rfllrkwlrv rerkecsess sqqssqqssh
      121 dddssrflsp rareestasn snrstpacsp ilrkrsrspt pqnqdgdtmv ekgsdhssdk
      181 spstpeqgvq rscssqsgrs ggknskksqs wynvlsptyk qrnedfrklf kqlpdterli
      241 vdyscalqrd illqgrlyls enwicfysni frwetlltvr lkdicsmtke ktarlipnai
      301 qvctdsekhf ftsfgardrt ymmmfrlwqn allekplcpk elwhfvhqcy gnelgltsdd
      361 edyvppdddf ntmgyceeip veenevndss skssietkpd aspqlpkksi tnstltstgs
      421 seapvsfdgl pleeealegd gslekelaid nimgekiemi apvnspsldf ndnediptel
      481 sdssdthdeg evqafyedls grqyvnevfn fsvdklydll ftnspfqrdf meqrrfsdii
      541 fhpwkkeeng nqsrvilyti tltnplapkt atvretqtmy kasqesecyv idaevlthdv
      601 pyhdyfytin rytltrvarn ksrlrvstel ryrkqpwglv ktfieknfws gledyfrhle
      661 selaktesty laemhrqspk ekasktttvr rrkrphahlr vphleevmsp vttptdedvg
      721 hrikhvagst qtrhipedtp ngfhlqsvsk lllviscvlv llvilnmmlf yklwmleytt
      781 qtltawqglr lqerlpqsqt ewaqllesqq kyhdtelqkw reiikssvml ldqvrcptfs
      841 acpglwergl lplccekdpr lyhhppdfsl qfilppghal f
//
LOCUS       XP_054225434             880 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Aster-B isoform X3 [Homo sapiens].
ACCESSION   XP_054225434
VERSION     XP_054225434.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369459.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..880
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..880
                     /product="protein Aster-B isoform X3"
                     /calculated_mol_wt=101211
     Region          234..327
                     /region_name="PH-GRAM_GRAMDC"
                     /note="GRAM domain-containing protein (GRAMDC) Pleckstrin
                     Homology-Glucosyltransferases, Rab-like GTPase activators
                     and Myotubularins (PH-GRAM) domain; cd13220"
                     /db_xref="CDD:275406"
     Region          504..650
                     /region_name="VASt"
                     /note="VAD1 Analog of StAR-related lipid transfer domain;
                     pfam16016"
                     /db_xref="CDD:464975"
     CDS             1..880
                     /gene="GRAMD1B"
                     /gene_synonym="LINC01059"
                     /coded_by="XM_054369459.1:115..2757"
                     /db_xref="GeneID:57476"
                     /db_xref="HGNC:HGNC:29214"
                     /db_xref="MIM:620179"
ORIGIN      
        1 mvpepqgape gspvwsssst ptlrrrrfkm rrmknvqeqs leaglardlp avlapgkefl
       61 qlpsieitps sdedtpwsnc stpsasprrk rfllrkwlrv rerkecsess qqssqqsshd
      121 ddssrflspr areestasns nrstpacspi lrkrsrsptp qnqdgdtmve kgsdhssdks
      181 pstpeqgvqr scssqsgrsg gknskksqsw ynvlsptykq rnedfrklfk qlpdterliv
      241 dyscalqrdi llqgrlylse nwicfysnif rwetlltvrl kdicsmtkek tarlipnaiq
      301 vctdsekhff tsfgardrty mmmfrlwqna llekplcpke lwhfvhqcyg nelgltsdde
      361 dyvppdddfn tmgyceeipv eenevndsss kssietkpda spqlpkksit nstltstgss
      421 eapvsfdglp leeealegdg slekelaidn imgekiemia pvnspsldfn dnediptels
      481 dssdthdege vqafyedlsg rqyvnevfnf svdklydllf tnspfqrdfm eqrrfsdiif
      541 hpwkkeengn qsrvilytit ltnplapkta tvretqtmyk asqesecyvi daevlthdvp
      601 yhdyfytinr ytltrvarnk srlrvstelr yrkqpwglvk tfieknfwsg ledyfrhles
      661 elaktestyl aemhrqspke kasktttvrr rkrphahlrv phleevmspv ttptdedvgh
      721 rikhvagstq trhipedtpn gfhlqsvskl llviscvlvl lvilnmmlfy klwmleyttq
      781 tltawqglrl qerlpqsqte waqllesqqk yhdtelqkwr eiikssvmll dqvrcptfsa
      841 cpglwergll plccekdprl yhhppdfslq filppghalf
//
LOCUS       XP_054225435             866 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Aster-B isoform X4 [Homo sapiens].
ACCESSION   XP_054225435
VERSION     XP_054225435.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369460.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..866
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..866
                     /product="protein Aster-B isoform X4"
                     /calculated_mol_wt=99813
     Region          235..328
                     /region_name="PH-GRAM_GRAMDC"
                     /note="GRAM domain-containing protein (GRAMDC) Pleckstrin
                     Homology-Glucosyltransferases, Rab-like GTPase activators
                     and Myotubularins (PH-GRAM) domain; cd13220"
                     /db_xref="CDD:275406"
     Region          505..651
                     /region_name="VASt"
                     /note="VAD1 Analog of StAR-related lipid transfer domain;
                     pfam16016"
                     /db_xref="CDD:464975"
     CDS             1..866
                     /gene="GRAMD1B"
                     /gene_synonym="LINC01059"
                     /coded_by="XM_054369460.1:115..2715"
                     /db_xref="GeneID:57476"
                     /db_xref="HGNC:HGNC:29214"
                     /db_xref="MIM:620179"
ORIGIN      
        1 mvpepqgape gspvwsssst ptlrrrrfkm rrmknvqeqs leaglardlp avlapgkefl
       61 qlpsieitps sdedtpwsnc stpsasprrk rfllrkwlrv rerkecsess sqqssqqssh
      121 dddssrflsp rareestasn snrstpacsp ilrkrsrspt pqnqdgdtmv ekgsdhssdk
      181 spstpeqgvq rscssqsgrs ggknskksqs wynvlsptyk qrnedfrklf kqlpdterli
      241 vdyscalqrd illqgrlyls enwicfysni frwetlltvr lkdicsmtke ktarlipnai
      301 qvctdsekhf ftsfgardrt ymmmfrlwqn allekplcpk elwhfvhqcy gnelgltsdd
      361 edyvppdddf ntmgyceeip veenevndss skssietkpd aspqlpkksi tnstltstgs
      421 seapvsfdgl pleeealegd gslekelaid nimgekiemi apvnspsldf ndnediptel
      481 sdssdthdeg evqafyedls grqyvnevfn fsvdklydll ftnspfqrdf meqrrfsdii
      541 fhpwkkeeng nqsrvilyti tltnplapkt atvretqtmy kasqesecyv idaevlthdv
      601 pyhdyfytin rytltrvarn ksrlrvstel ryrkqpwglv ktfieknfws gledyfrhle
      661 selaktesty laemhrqspk ekasktttvr rrkrphahlr vphleevmsp vttptdedvg
      721 hrikhvagst qtrhipedtp ngfhlqsvsk lllviscvic fslvllviln mmlfyklwml
      781 eyttqtltaw qglrlqerlp qsqtewaqll esqqkyhdte lqkwreiiks svmlldqmkd
      841 slinlqngir srdytsesee krnryh
//
LOCUS       XP_054225436             852 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Aster-B isoform X5 [Homo sapiens].
ACCESSION   XP_054225436
VERSION     XP_054225436.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369461.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..852
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..852
                     /product="protein Aster-B isoform X5"
                     /calculated_mol_wt=98075
     Region          206..299
                     /region_name="PH-GRAM_GRAMDC"
                     /note="GRAM domain-containing protein (GRAMDC) Pleckstrin
                     Homology-Glucosyltransferases, Rab-like GTPase activators
                     and Myotubularins (PH-GRAM) domain; cd13220"
                     /db_xref="CDD:275406"
     Region          476..622
                     /region_name="VASt"
                     /note="VAD1 Analog of StAR-related lipid transfer domain;
                     pfam16016"
                     /db_xref="CDD:464975"
     CDS             1..852
                     /gene="GRAMD1B"
                     /gene_synonym="LINC01059"
                     /coded_by="XM_054369461.1:473..3031"
                     /db_xref="GeneID:57476"
                     /db_xref="HGNC:HGNC:29214"
                     /db_xref="MIM:620179"
ORIGIN      
        1 mrrmknvqeq sleaglardl pavlapgkef lqlpsieitp ssdedtpwsn cstpsasprr
       61 krfllrkwlr vrerkecses ssqqssqqss hdddssrfls prareestas nsnrstpacs
      121 pilrkrsrsp tpqnqdgdtm vekgsdhssd kspstpeqgv qrscssqsgr sggknskksq
      181 swynvlspty kqrnedfrkl fkqlpdterl ivdyscalqr dillqgrlyl senwicfysn
      241 ifrwetlltv rlkdicsmtk ektarlipna iqvctdsekh fftsfgardr tymmmfrlwq
      301 nallekplcp kelwhfvhqc ygnelgltsd dedyvppddd fntmgyceei pveenevnds
      361 sskssietkp daspqlpkks itnstltstg sseapvsfdg lpleeealeg dgslekelai
      421 dnimgekiem iapvnspsld fndnedipte lsdssdthde gevqafyedl sgrqyvnevf
      481 nfsvdklydl lftnspfqrd fmeqrrfsdi ifhpwkkeen gnqsrvilyt itltnplapk
      541 tatvretqtm ykasqesecy vidaevlthd vpyhdyfyti nrytltrvar nksrlrvste
      601 lryrkqpwgl vktfieknfw sgledyfrhl eselaktest ylaemhrqsp kekasktttv
      661 rrrkrphahl rvphleevms pvttptdedv ghrikhvags tqtrhipedt pngfhlqsvs
      721 klllviscvl vllvilnmml fyklwmleyt tqtltawqgl rlqerlpqsq tewaqllesq
      781 qkyhdtelqk wreiikssvm lldqvrcptf sacpglwerg llplccekdp rlyhhppdfs
      841 lqfilppgha lf
//
LOCUS       XP_054225437             852 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Aster-B isoform X5 [Homo sapiens].
ACCESSION   XP_054225437
VERSION     XP_054225437.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369462.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 12% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..852
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..852
                     /product="protein Aster-B isoform X5"
                     /calculated_mol_wt=98075
     Region          206..299
                     /region_name="PH-GRAM_GRAMDC"
                     /note="GRAM domain-containing protein (GRAMDC) Pleckstrin
                     Homology-Glucosyltransferases, Rab-like GTPase activators
                     and Myotubularins (PH-GRAM) domain; cd13220"
                     /db_xref="CDD:275406"
     Region          476..622
                     /region_name="VASt"
                     /note="VAD1 Analog of StAR-related lipid transfer domain;
                     pfam16016"
                     /db_xref="CDD:464975"
     CDS             1..852
                     /gene="GRAMD1B"
                     /gene_synonym="LINC01059"
                     /coded_by="XM_054369462.1:463..3021"
                     /db_xref="GeneID:57476"
                     /db_xref="HGNC:HGNC:29214"
                     /db_xref="MIM:620179"
ORIGIN      
        1 mrrmknvqeq sleaglardl pavlapgkef lqlpsieitp ssdedtpwsn cstpsasprr
       61 krfllrkwlr vrerkecses ssqqssqqss hdddssrfls prareestas nsnrstpacs
      121 pilrkrsrsp tpqnqdgdtm vekgsdhssd kspstpeqgv qrscssqsgr sggknskksq
      181 swynvlspty kqrnedfrkl fkqlpdterl ivdyscalqr dillqgrlyl senwicfysn
      241 ifrwetlltv rlkdicsmtk ektarlipna iqvctdsekh fftsfgardr tymmmfrlwq
      301 nallekplcp kelwhfvhqc ygnelgltsd dedyvppddd fntmgyceei pveenevnds
      361 sskssietkp daspqlpkks itnstltstg sseapvsfdg lpleeealeg dgslekelai
      421 dnimgekiem iapvnspsld fndnedipte lsdssdthde gevqafyedl sgrqyvnevf
      481 nfsvdklydl lftnspfqrd fmeqrrfsdi ifhpwkkeen gnqsrvilyt itltnplapk
      541 tatvretqtm ykasqesecy vidaevlthd vpyhdyfyti nrytltrvar nksrlrvste
      601 lryrkqpwgl vktfieknfw sgledyfrhl eselaktest ylaemhrqsp kekasktttv
      661 rrrkrphahl rvphleevms pvttptdedv ghrikhvags tqtrhipedt pngfhlqsvs
      721 klllviscvl vllvilnmml fyklwmleyt tqtltawqgl rlqerlpqsq tewaqllesq
      781 qkyhdtelqk wreiikssvm lldqvrcptf sacpglwerg llplccekdp rlyhhppdfs
      841 lqfilppgha lf
//
LOCUS       XP_054225438             802 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Aster-B isoform X6 [Homo sapiens].
ACCESSION   XP_054225438
VERSION     XP_054225438.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369463.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..802
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..802
                     /product="protein Aster-B isoform X6"
                     /calculated_mol_wt=92286
     Region          156..249
                     /region_name="PH-GRAM_GRAMDC"
                     /note="GRAM domain-containing protein (GRAMDC) Pleckstrin
                     Homology-Glucosyltransferases, Rab-like GTPase activators
                     and Myotubularins (PH-GRAM) domain; cd13220"
                     /db_xref="CDD:275406"
     Region          426..572
                     /region_name="VASt"
                     /note="VAD1 Analog of StAR-related lipid transfer domain;
                     pfam16016"
                     /db_xref="CDD:464975"
     CDS             1..802
                     /gene="GRAMD1B"
                     /gene_synonym="LINC01059"
                     /coded_by="XM_054369463.1:190..2598"
                     /db_xref="GeneID:57476"
                     /db_xref="HGNC:HGNC:29214"
                     /db_xref="MIM:620179"
ORIGIN      
        1 mkshcitqag lktpglqrss flnlpkcwdy ssqqssqqss hdddssrfls prareestas
       61 nsnrstpacs pilrkrsrsp tpqnqdgdtm vekgsdhssd kspstpeqgv qrscssqsgr
      121 sggknskksq swynvlspty kqrnedfrkl fkqlpdterl ivdyscalqr dillqgrlyl
      181 senwicfysn ifrwetlltv rlkdicsmtk ektarlipna iqvctdsekh fftsfgardr
      241 tymmmfrlwq nallekplcp kelwhfvhqc ygnelgltsd dedyvppddd fntmgyceei
      301 pveenevnds sskssietkp daspqlpkks itnstltstg sseapvsfdg lpleeealeg
      361 dgslekelai dnimgekiem iapvnspsld fndnedipte lsdssdthde gevqafyedl
      421 sgrqyvnevf nfsvdklydl lftnspfqrd fmeqrrfsdi ifhpwkkeen gnqsrvilyt
      481 itltnplapk tatvretqtm ykasqesecy vidaevlthd vpyhdyfyti nrytltrvar
      541 nksrlrvste lryrkqpwgl vktfieknfw sgledyfrhl eselaktest ylaemhrqsp
      601 kekasktttv rrrkrphahl rvphleevms pvttptdedv ghrikhvags tqtrhipedt
      661 pngfhlqsvs klllviscvl vllvilnmml fyklwmleyt tqtltawqgl rlqerlpqsq
      721 tewaqllesq qkyhdtelqk wreiikssvm lldqvrcptf sacpglwerg llplccekdp
      781 rlyhhppdfs lqfilppgha lf
//
LOCUS       XP_054225439             798 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Aster-B isoform X21 [Homo sapiens].
ACCESSION   XP_054225439
VERSION     XP_054225439.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369464.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..798
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..798
                     /product="protein Aster-B isoform X21"
                     /calculated_mol_wt=91918
     Region          152..245
                     /region_name="PH-GRAM_GRAMDC"
                     /note="GRAM domain-containing protein (GRAMDC) Pleckstrin
                     Homology-Glucosyltransferases, Rab-like GTPase activators
                     and Myotubularins (PH-GRAM) domain; cd13220"
                     /db_xref="CDD:275406"
     Region          422..568
                     /region_name="VASt"
                     /note="VAD1 Analog of StAR-related lipid transfer domain;
                     pfam16016"
                     /db_xref="CDD:464975"
     CDS             1..798
                     /gene="GRAMD1B"
                     /gene_synonym="LINC01059"
                     /coded_by="XM_054369464.1:552..2948"
                     /db_xref="GeneID:57476"
                     /db_xref="HGNC:HGNC:29214"
                     /db_xref="MIM:620179"
ORIGIN      
        1 mrawfqteav gvmngrrmds rvtkevssqq ssqqsshddd ssrflsprar eestasnsnr
       61 stpacspilr krsrsptpqn qdgdtmvekg sdhssdksps tpeqgvqrsc ssqsgrsggk
      121 nskksqswyn vlsptykqrn edfrklfkql pdterlivdy scalqrdill qgrlylsenw
      181 icfysnifrw etlltvrlkd icsmtkekta rlipnaiqvc tdsekhffts fgardrtymm
      241 mfrlwqnall ekplcpkelw hfvhqcygne lgltsddedy vppdddfntm gyceeipvee
      301 nevndsssks sietkpdasp qlpkksitns tltstgssea pvsfdglple eealegdgsl
      361 ekelaidnim gekiemiapv nspsldfndn ediptelsds sdthdegevq afyedlsgrq
      421 yvnevfnfsv dklydllftn spfqrdfmeq rrfsdiifhp wkkeengnqs rvilytitlt
      481 nplapktatv retqtmykas qesecyvida evlthdvpyh dyfytinryt ltrvarnksr
      541 lrvstelryr kqpwglvktf ieknfwsgle dyfrhlesel aktestylae mhrqspkeka
      601 sktttvrrrk rphahlrvph leevmspvtt ptdedvghri khvagstqtr hipedtpngf
      661 hlqsvsklll viscvlvllv ilnmmlfykl wmleyttqtl tawqglrlqe rlpqsqtewa
      721 qllesqqkyh dtelqkwrei ikssvmlldq vrcptfsacp glwergllpl ccekdprlyh
      781 hppdfslqfi lppghalf
//
LOCUS       XP_054225440             796 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Aster-B isoform X7 [Homo sapiens].
ACCESSION   XP_054225440
VERSION     XP_054225440.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369465.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..796
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..796
                     /product="protein Aster-B isoform X7"
                     /calculated_mol_wt=91640
     Region          150..243
                     /region_name="PH-GRAM_GRAMDC"
                     /note="GRAM domain-containing protein (GRAMDC) Pleckstrin
                     Homology-Glucosyltransferases, Rab-like GTPase activators
                     and Myotubularins (PH-GRAM) domain; cd13220"
                     /db_xref="CDD:275406"
     Region          420..566
                     /region_name="VASt"
                     /note="VAD1 Analog of StAR-related lipid transfer domain;
                     pfam16016"
                     /db_xref="CDD:464975"
     CDS             1..796
                     /gene="GRAMD1B"
                     /gene_synonym="LINC01059"
                     /coded_by="XM_054369465.1:300..2690"
                     /db_xref="GeneID:57476"
                     /db_xref="HGNC:HGNC:29214"
                     /db_xref="MIM:620179"
ORIGIN      
        1 mepgstrtyr slmthlrstg rllnssqqss qqsshdddss rflspraree stasnsnrst
       61 pacspilrkr srsptpqnqd gdtmvekgsd hssdkspstp eqgvqrscss qsgrsggkns
      121 kksqswynvl sptykqrned frklfkqlpd terlivdysc alqrdillqg rlylsenwic
      181 fysnifrwet lltvrlkdic smtkektarl ipnaiqvctd sekhfftsfg ardrtymmmf
      241 rlwqnallek plcpkelwhf vhqcygnelg ltsddedyvp pdddfntmgy ceeipveene
      301 vndssskssi etkpdaspql pkksitnstl tstgsseapv sfdglpleee alegdgslek
      361 elaidnimge kiemiapvns psldfndned iptelsdssd thdegevqaf yedlsgrqyv
      421 nevfnfsvdk lydllftnsp fqrdfmeqrr fsdiifhpwk keengnqsrv ilytitltnp
      481 lapktatvre tqtmykasqe secyvidaev lthdvpyhdy fytinrytlt rvarnksrlr
      541 vstelryrkq pwglvktfie knfwsgledy frhleselak testylaemh rqspkekask
      601 tttvrrrkrp hahlrvphle evmspvttpt dedvghrikh vagstqtrhi pedtpngfhl
      661 qsvsklllvi scvlvllvil nmmlfyklwm leyttqtlta wqglrlqerl pqsqtewaql
      721 lesqqkyhdt elqkwreiik ssvmlldqvr cptfsacpgl wergllplcc ekdprlyhhp
      781 pdfslqfilp pghalf
//
LOCUS       XP_054225441             795 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Aster-B isoform X8 [Homo sapiens].
ACCESSION   XP_054225441
VERSION     XP_054225441.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369466.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..795
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..795
                     /product="protein Aster-B isoform X8"
                     /calculated_mol_wt=91553
     Region          149..242
                     /region_name="PH-GRAM_GRAMDC"
                     /note="GRAM domain-containing protein (GRAMDC) Pleckstrin
                     Homology-Glucosyltransferases, Rab-like GTPase activators
                     and Myotubularins (PH-GRAM) domain; cd13220"
                     /db_xref="CDD:275406"
     Region          419..565
                     /region_name="VASt"
                     /note="VAD1 Analog of StAR-related lipid transfer domain;
                     pfam16016"
                     /db_xref="CDD:464975"
     CDS             1..795
                     /gene="GRAMD1B"
                     /gene_synonym="LINC01059"
                     /coded_by="XM_054369466.1:300..2687"
                     /db_xref="GeneID:57476"
                     /db_xref="HGNC:HGNC:29214"
                     /db_xref="MIM:620179"
ORIGIN      
        1 mepgstrtyr slmthlrstg rllnsqqssq qsshdddssr flsprarees tasnsnrstp
       61 acspilrkrs rsptpqnqdg dtmvekgsdh ssdkspstpe qgvqrscssq sgrsggknsk
      121 ksqswynvls ptykqrnedf rklfkqlpdt erlivdysca lqrdillqgr lylsenwicf
      181 ysnifrwetl ltvrlkdics mtkektarli pnaiqvctds ekhfftsfga rdrtymmmfr
      241 lwqnallekp lcpkelwhfv hqcygnelgl tsddedyvpp dddfntmgyc eeipveenev
      301 ndssskssie tkpdaspqlp kksitnstlt stgsseapvs fdglpleeea legdgsleke
      361 laidnimgek iemiapvnsp sldfndnedi ptelsdssdt hdegevqafy edlsgrqyvn
      421 evfnfsvdkl ydllftnspf qrdfmeqrrf sdiifhpwkk eengnqsrvi lytitltnpl
      481 apktatvret qtmykasqes ecyvidaevl thdvpyhdyf ytinrytltr varnksrlrv
      541 stelryrkqp wglvktfiek nfwsgledyf rhleselakt estylaemhr qspkekaskt
      601 ttvrrrkrph ahlrvphlee vmspvttptd edvghrikhv agstqtrhip edtpngfhlq
      661 svsklllvis cvlvllviln mmlfyklwml eyttqtltaw qglrlqerlp qsqtewaqll
      721 esqqkyhdte lqkwreiiks svmlldqvrc ptfsacpglw ergllplcce kdprlyhhpp
      781 dfslqfilpp ghalf
//
LOCUS       XP_054225442             783 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Aster-B isoform X9 [Homo sapiens].
ACCESSION   XP_054225442
VERSION     XP_054225442.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369467.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..783
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..783
                     /product="protein Aster-B isoform X9"
                     /calculated_mol_wt=90351
     Region          156..249
                     /region_name="PH-GRAM_GRAMDC"
                     /note="GRAM domain-containing protein (GRAMDC) Pleckstrin
                     Homology-Glucosyltransferases, Rab-like GTPase activators
                     and Myotubularins (PH-GRAM) domain; cd13220"
                     /db_xref="CDD:275406"
     Region          426..572
                     /region_name="VASt"
                     /note="VAD1 Analog of StAR-related lipid transfer domain;
                     pfam16016"
                     /db_xref="CDD:464975"
     CDS             1..783
                     /gene="GRAMD1B"
                     /gene_synonym="LINC01059"
                     /coded_by="XM_054369467.1:190..2541"
                     /db_xref="GeneID:57476"
                     /db_xref="HGNC:HGNC:29214"
                     /db_xref="MIM:620179"
ORIGIN      
        1 mkshcitqag lktpglqrss flnlpkcwdy ssqqssqqss hdddssrfls prareestas
       61 nsnrstpacs pilrkrsrsp tpqnqdgdtm vekgsdhssd kspstpeqgv qrscssqsgr
      121 sggknskksq swynvlspty kqrnedfrkl fkqlpdterl ivdyscalqr dillqgrlyl
      181 senwicfysn ifrwetlltv rlkdicsmtk ektarlipna iqvctdsekh fftsfgardr
      241 tymmmfrlwq nallekplcp kelwhfvhqc ygnelgltsd dedyvppddd fntmgyceei
      301 pveenevnds sskssietkp daspqlpkks itnstltstg sseapvsfdg lpleeealeg
      361 dgslekelai dnimgekiem iapvnspsld fndnedipte lsdssdthde gevqafyedl
      421 sgrqyvnevf nfsvdklydl lftnspfqrd fmeqrrfsdi ifhpwkkeen gnqsrvilyt
      481 itltnplapk tatvretqtm ykasqesecy vidaevlthd vpyhdyfyti nrytltrvar
      541 nksrlrvste lryrkqpwgl vktfieknfw sgledyfrhl eselaktest ylaemhrqsp
      601 kekasktttv rrrkrphahl rvphleevms pvttptdedv ghrikhvags tqtrhipedt
      661 pngfhlqsvs klllviscvl vllvilnmml fyklwmleyt tqtltawqgl rlqerlpqsq
      721 tewaqllesq qkyhdtelqk wreiikssvm lldqmkdsli nlqngirsrd ytseseekrn
      781 ryh
//
LOCUS       XP_054225443             780 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Aster-B isoform X10 [Homo sapiens].
ACCESSION   XP_054225443
VERSION     XP_054225443.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369468.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..780
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..780
                     /product="protein Aster-B isoform X10"
                     /calculated_mol_wt=89684
     Region          134..227
                     /region_name="PH-GRAM_GRAMDC"
                     /note="GRAM domain-containing protein (GRAMDC) Pleckstrin
                     Homology-Glucosyltransferases, Rab-like GTPase activators
                     and Myotubularins (PH-GRAM) domain; cd13220"
                     /db_xref="CDD:275406"
     Region          404..550
                     /region_name="VASt"
                     /note="VAD1 Analog of StAR-related lipid transfer domain;
                     pfam16016"
                     /db_xref="CDD:464975"
     CDS             1..780
                     /gene="GRAMD1B"
                     /gene_synonym="LINC01059"
                     /coded_by="XM_054369468.1:353..2695"
                     /db_xref="GeneID:57476"
                     /db_xref="HGNC:HGNC:29214"
                     /db_xref="MIM:620179"
ORIGIN      
        1 msaspsrsss qqssqqsshd ddssrflspr areestasns nrstpacspi lrkrsrsptp
       61 qnqdgdtmve kgsdhssdks pstpeqgvqr scssqsgrsg gknskksqsw ynvlsptykq
      121 rnedfrklfk qlpdterliv dyscalqrdi llqgrlylse nwicfysnif rwetlltvrl
      181 kdicsmtkek tarlipnaiq vctdsekhff tsfgardrty mmmfrlwqna llekplcpke
      241 lwhfvhqcyg nelgltsdde dyvppdddfn tmgyceeipv eenevndsss kssietkpda
      301 spqlpkksit nstltstgss eapvsfdglp leeealegdg slekelaidn imgekiemia
      361 pvnspsldfn dnediptels dssdthdege vqafyedlsg rqyvnevfnf svdklydllf
      421 tnspfqrdfm eqrrfsdiif hpwkkeengn qsrvilytit ltnplapkta tvretqtmyk
      481 asqesecyvi daevlthdvp yhdyfytinr ytltrvarnk srlrvstelr yrkqpwglvk
      541 tfieknfwsg ledyfrhles elaktestyl aemhrqspke kasktttvrr rkrphahlrv
      601 phleevmspv ttptdedvgh rikhvagstq trhipedtpn gfhlqsvskl llviscvlvl
      661 lvilnmmlfy klwmleyttq tltawqglrl qerlpqsqte waqllesqqk yhdtelqkwr
      721 eiikssvmll dqvrcptfsa cpglwergll plccekdprl yhhppdfslq filppghalf
//
LOCUS       XP_054225444             772 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Aster-B isoform X22 [Homo sapiens].
ACCESSION   XP_054225444
VERSION     XP_054225444.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369469.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..772
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..772
                     /product="protein Aster-B isoform X22"
                     /calculated_mol_wt=88989
     Region          126..219
                     /region_name="PH-GRAM_GRAMDC"
                     /note="GRAM domain-containing protein (GRAMDC) Pleckstrin
                     Homology-Glucosyltransferases, Rab-like GTPase activators
                     and Myotubularins (PH-GRAM) domain; cd13220"
                     /db_xref="CDD:275406"
     Region          396..542
                     /region_name="VASt"
                     /note="VAD1 Analog of StAR-related lipid transfer domain;
                     pfam16016"
                     /db_xref="CDD:464975"
     CDS             1..772
                     /gene="GRAMD1B"
                     /gene_synonym="LINC01059"
                     /coded_by="XM_054369469.1:139..2457"
                     /db_xref="GeneID:57476"
                     /db_xref="HGNC:HGNC:29214"
                     /db_xref="MIM:620179"
ORIGIN      
        1 mdrekkntsk rcsleledpd dsalpritas nsnrstpacs pilrkrsrsp tpqnqdgdtm
       61 vekgsdhssd kspstpeqgv qrscssqsgr sggknskksq swynvlspty kqrnedfrkl
      121 fkqlpdterl ivdyscalqr dillqgrlyl senwicfysn ifrwetlltv rlkdicsmtk
      181 ektarlipna iqvctdsekh fftsfgardr tymmmfrlwq nallekplcp kelwhfvhqc
      241 ygnelgltsd dedyvppddd fntmgyceei pveenevnds sskssietkp daspqlpkks
      301 itnstltstg sseapvsfdg lpleeealeg dgslekelai dnimgekiem iapvnspsld
      361 fndnedipte lsdssdthde gevqafyedl sgrqyvnevf nfsvdklydl lftnspfqrd
      421 fmeqrrfsdi ifhpwkkeen gnqsrvilyt itltnplapk tatvretqtm ykasqesecy
      481 vidaevlthd vpyhdyfyti nrytltrvar nksrlrvste lryrkqpwgl vktfieknfw
      541 sgledyfrhl eselaktest ylaemhrqsp kekasktttv rrrkrphahl rvphleevms
      601 pvttptdedv ghrikhvags tqtrhipedt pngfhlqsvs klllviscvl vllvilnmml
      661 fyklwmleyt tqtltawqgl rlqerlpqsq tewaqllesq qkyhdtelqk wreiikssvm
      721 lldqvrcptf sacpglwerg llplccekdp rlyhhppdfs lqfilppgha lf
//
LOCUS       XP_054225445             770 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Aster-B isoform X11 [Homo sapiens].
ACCESSION   XP_054225445
VERSION     XP_054225445.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369470.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..770
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..770
                     /product="protein Aster-B isoform X11"
                     /calculated_mol_wt=88706
     Region          124..217
                     /region_name="PH-GRAM_GRAMDC"
                     /note="GRAM domain-containing protein (GRAMDC) Pleckstrin
                     Homology-Glucosyltransferases, Rab-like GTPase activators
                     and Myotubularins (PH-GRAM) domain; cd13220"
                     /db_xref="CDD:275406"
     Region          394..540
                     /region_name="VASt"
                     /note="VAD1 Analog of StAR-related lipid transfer domain;
                     pfam16016"
                     /db_xref="CDD:464975"
     CDS             1..770
                     /gene="GRAMD1B"
                     /gene_synonym="LINC01059"
                     /coded_by="XM_054369470.1:301..2613"
                     /db_xref="GeneID:57476"
                     /db_xref="HGNC:HGNC:29214"
                     /db_xref="MIM:620179"
ORIGIN      
        1 mepgstrtyr slmthlrstg rllnstasns nrstpacspi lrkrsrsptp qnqdgdtmve
       61 kgsdhssdks pstpeqgvqr scssqsgrsg gknskksqsw ynvlsptykq rnedfrklfk
      121 qlpdterliv dyscalqrdi llqgrlylse nwicfysnif rwetlltvrl kdicsmtkek
      181 tarlipnaiq vctdsekhff tsfgardrty mmmfrlwqna llekplcpke lwhfvhqcyg
      241 nelgltsdde dyvppdddfn tmgyceeipv eenevndsss kssietkpda spqlpkksit
      301 nstltstgss eapvsfdglp leeealegdg slekelaidn imgekiemia pvnspsldfn
      361 dnediptels dssdthdege vqafyedlsg rqyvnevfnf svdklydllf tnspfqrdfm
      421 eqrrfsdiif hpwkkeengn qsrvilytit ltnplapkta tvretqtmyk asqesecyvi
      481 daevlthdvp yhdyfytinr ytltrvarnk srlrvstelr yrkqpwglvk tfieknfwsg
      541 ledyfrhles elaktestyl aemhrqspke kasktttvrr rkrphahlrv phleevmspv
      601 ttptdedvgh rikhvagstq trhipedtpn gfhlqsvskl llviscvlvl lvilnmmlfy
      661 klwmleyttq tltawqglrl qerlpqsqte waqllesqqk yhdtelqkwr eiikssvmll
      721 dqvrcptfsa cpglwergll plccekdprl yhhppdfslq filppghalf
//
LOCUS       XP_054225446             779 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Aster-B isoform X23 [Homo sapiens].
ACCESSION   XP_054225446
VERSION     XP_054225446.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369471.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..779
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..779
                     /product="protein Aster-B isoform X23"
                     /calculated_mol_wt=89982
     Region          152..245
                     /region_name="PH-GRAM_GRAMDC"
                     /note="GRAM domain-containing protein (GRAMDC) Pleckstrin
                     Homology-Glucosyltransferases, Rab-like GTPase activators
                     and Myotubularins (PH-GRAM) domain; cd13220"
                     /db_xref="CDD:275406"
     Region          422..568
                     /region_name="VASt"
                     /note="VAD1 Analog of StAR-related lipid transfer domain;
                     pfam16016"
                     /db_xref="CDD:464975"
     CDS             1..779
                     /gene="GRAMD1B"
                     /gene_synonym="LINC01059"
                     /coded_by="XM_054369471.1:548..2887"
                     /db_xref="GeneID:57476"
                     /db_xref="HGNC:HGNC:29214"
                     /db_xref="MIM:620179"
ORIGIN      
        1 mrawfqteav gvmngrrmds rvtkevssqq ssqqsshddd ssrflsprar eestasnsnr
       61 stpacspilr krsrsptpqn qdgdtmvekg sdhssdksps tpeqgvqrsc ssqsgrsggk
      121 nskksqswyn vlsptykqrn edfrklfkql pdterlivdy scalqrdill qgrlylsenw
      181 icfysnifrw etlltvrlkd icsmtkekta rlipnaiqvc tdsekhffts fgardrtymm
      241 mfrlwqnall ekplcpkelw hfvhqcygne lgltsddedy vppdddfntm gyceeipvee
      301 nevndsssks sietkpdasp qlpkksitns tltstgssea pvsfdglple eealegdgsl
      361 ekelaidnim gekiemiapv nspsldfndn ediptelsds sdthdegevq afyedlsgrq
      421 yvnevfnfsv dklydllftn spfqrdfmeq rrfsdiifhp wkkeengnqs rvilytitlt
      481 nplapktatv retqtmykas qesecyvida evlthdvpyh dyfytinryt ltrvarnksr
      541 lrvstelryr kqpwglvktf ieknfwsgle dyfrhlesel aktestylae mhrqspkeka
      601 sktttvrrrk rphahlrvph leevmspvtt ptdedvghri khvagstqtr hipedtpngf
      661 hlqsvsklll viscvlvllv ilnmmlfykl wmleyttqtl tawqglrlqe rlpqsqtewa
      721 qllesqqkyh dtelqkwrei ikssvmlldq mkdslinlqn girsrdytse seekrnryh
//
LOCUS       XP_054225447             754 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Aster-B isoform X12 [Homo sapiens].
ACCESSION   XP_054225447
VERSION     XP_054225447.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369472.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..754
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..754
                     /product="protein Aster-B isoform X12"
                     /calculated_mol_wt=86750
     Region          108..201
                     /region_name="PH-GRAM_GRAMDC"
                     /note="GRAM domain-containing protein (GRAMDC) Pleckstrin
                     Homology-Glucosyltransferases, Rab-like GTPase activators
                     and Myotubularins (PH-GRAM) domain; cd13220"
                     /db_xref="CDD:275406"
     Region          378..524
                     /region_name="VASt"
                     /note="VAD1 Analog of StAR-related lipid transfer domain;
                     pfam16016"
                     /db_xref="CDD:464975"
     CDS             1..754
                     /gene="GRAMD1B"
                     /gene_synonym="LINC01059"
                     /coded_by="XM_054369472.1:353..2617"
                     /db_xref="GeneID:57476"
                     /db_xref="HGNC:HGNC:29214"
                     /db_xref="MIM:620179"
ORIGIN      
        1 msaspsrsst asnsnrstpa cspilrkrsr sptpqnqdgd tmvekgsdhs sdkspstpeq
       61 gvqrscssqs grsggknskk sqswynvlsp tykqrnedfr klfkqlpdte rlivdyscal
      121 qrdillqgrl ylsenwicfy snifrwetll tvrlkdicsm tkektarlip naiqvctdse
      181 khfftsfgar drtymmmfrl wqnallekpl cpkelwhfvh qcygnelglt sddedyvppd
      241 ddfntmgyce eipveenevn dssskssiet kpdaspqlpk ksitnstlts tgsseapvsf
      301 dglpleeeal egdgslekel aidnimgeki emiapvnsps ldfndnedip telsdssdth
      361 degevqafye dlsgrqyvne vfnfsvdkly dllftnspfq rdfmeqrrfs diifhpwkke
      421 engnqsrvil ytitltnpla pktatvretq tmykasqese cyvidaevlt hdvpyhdyfy
      481 tinrytltrv arnksrlrvs telryrkqpw glvktfiekn fwsgledyfr hleselakte
      541 stylaemhrq spkekasktt tvrrrkrpha hlrvphleev mspvttptde dvghrikhva
      601 gstqtrhipe dtpngfhlqs vsklllvisc vlvllvilnm mlfyklwmle yttqtltawq
      661 glrlqerlpq sqtewaqlle sqqkyhdtel qkwreiikss vmlldqvrcp tfsacpglwe
      721 rgllplccek dprlyhhppd fslqfilppg half
//
LOCUS       XP_054225448             753 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Aster-B isoform X24 [Homo sapiens].
ACCESSION   XP_054225448
VERSION     XP_054225448.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369473.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..753
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..753
                     /product="protein Aster-B isoform X24"
                     /calculated_mol_wt=87053
     Region          126..219
                     /region_name="PH-GRAM_GRAMDC"
                     /note="GRAM domain-containing protein (GRAMDC) Pleckstrin
                     Homology-Glucosyltransferases, Rab-like GTPase activators
                     and Myotubularins (PH-GRAM) domain; cd13220"
                     /db_xref="CDD:275406"
     Region          396..542
                     /region_name="VASt"
                     /note="VAD1 Analog of StAR-related lipid transfer domain;
                     pfam16016"
                     /db_xref="CDD:464975"
     CDS             1..753
                     /gene="GRAMD1B"
                     /gene_synonym="LINC01059"
                     /coded_by="XM_054369473.1:136..2397"
                     /db_xref="GeneID:57476"
                     /db_xref="HGNC:HGNC:29214"
                     /db_xref="MIM:620179"
ORIGIN      
        1 mdrekkntsk rcsleledpd dsalpritas nsnrstpacs pilrkrsrsp tpqnqdgdtm
       61 vekgsdhssd kspstpeqgv qrscssqsgr sggknskksq swynvlspty kqrnedfrkl
      121 fkqlpdterl ivdyscalqr dillqgrlyl senwicfysn ifrwetlltv rlkdicsmtk
      181 ektarlipna iqvctdsekh fftsfgardr tymmmfrlwq nallekplcp kelwhfvhqc
      241 ygnelgltsd dedyvppddd fntmgyceei pveenevnds sskssietkp daspqlpkks
      301 itnstltstg sseapvsfdg lpleeealeg dgslekelai dnimgekiem iapvnspsld
      361 fndnedipte lsdssdthde gevqafyedl sgrqyvnevf nfsvdklydl lftnspfqrd
      421 fmeqrrfsdi ifhpwkkeen gnqsrvilyt itltnplapk tatvretqtm ykasqesecy
      481 vidaevlthd vpyhdyfyti nrytltrvar nksrlrvste lryrkqpwgl vktfieknfw
      541 sgledyfrhl eselaktest ylaemhrqsp kekasktttv rrrkrphahl rvphleevms
      601 pvttptdedv ghrikhvags tqtrhipedt pngfhlqsvs klllviscvl vllvilnmml
      661 fyklwmleyt tqtltawqgl rlqerlpqsq tewaqllesq qkyhdtelqk wreiikssvm
      721 lldqmkdsli nlqngirsrd ytseseekrn ryh
//
LOCUS       XP_054225449             753 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Aster-B isoform X13 [Homo sapiens].
ACCESSION   XP_054225449
VERSION     XP_054225449.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369474.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..753
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..753
                     /product="protein Aster-B isoform X13"
                     /calculated_mol_wt=86754
     Region          107..200
                     /region_name="PH-GRAM_GRAMDC"
                     /note="GRAM domain-containing protein (GRAMDC) Pleckstrin
                     Homology-Glucosyltransferases, Rab-like GTPase activators
                     and Myotubularins (PH-GRAM) domain; cd13220"
                     /db_xref="CDD:275406"
     Region          377..523
                     /region_name="VASt"
                     /note="VAD1 Analog of StAR-related lipid transfer domain;
                     pfam16016"
                     /db_xref="CDD:464975"
     CDS             1..753
                     /gene="GRAMD1B"
                     /gene_synonym="LINC01059"
                     /coded_by="XM_054369474.1:524..2785"
                     /db_xref="GeneID:57476"
                     /db_xref="HGNC:HGNC:29214"
                     /db_xref="MIM:620179"
ORIGIN      
        1 mkgfklscta snsnrstpac spilrkrsrs ptpqnqdgdt mvekgsdhss dkspstpeqg
       61 vqrscssqsg rsggknskks qswynvlspt ykqrnedfrk lfkqlpdter livdyscalq
      121 rdillqgrly lsenwicfys nifrwetllt vrlkdicsmt kektarlipn aiqvctdsek
      181 hfftsfgard rtymmmfrlw qnallekplc pkelwhfvhq cygnelglts ddedyvppdd
      241 dfntmgycee ipveenevnd ssskssietk pdaspqlpkk sitnstltst gsseapvsfd
      301 glpleeeale gdgslekela idnimgekie miapvnspsl dfndnedipt elsdssdthd
      361 egevqafyed lsgrqyvnev fnfsvdklyd llftnspfqr dfmeqrrfsd iifhpwkkee
      421 ngnqsrvily titltnplap ktatvretqt mykasqesec yvidaevlth dvpyhdyfyt
      481 inrytltrva rnksrlrvst elryrkqpwg lvktfieknf wsgledyfrh leselaktes
      541 tylaemhrqs pkekaskttt vrrrkrphah lrvphleevm spvttptded vghrikhvag
      601 stqtrhiped tpngfhlqsv sklllviscv lvllvilnmm lfyklwmley ttqtltawqg
      661 lrlqerlpqs qtewaqlles qqkyhdtelq kwreiikssv mlldqvrcpt fsacpglwer
      721 gllplccekd prlyhhppdf slqfilppgh alf
//
LOCUS       XP_054225450             749 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Aster-B isoform X14 [Homo sapiens].
ACCESSION   XP_054225450
VERSION     XP_054225450.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369475.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..749
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..749
                     /product="protein Aster-B isoform X14"
                     /calculated_mol_wt=86236
     Region          103..196
                     /region_name="PH-GRAM_GRAMDC"
                     /note="GRAM domain-containing protein (GRAMDC) Pleckstrin
                     Homology-Glucosyltransferases, Rab-like GTPase activators
                     and Myotubularins (PH-GRAM) domain; cd13220"
                     /db_xref="CDD:275406"
     Region          373..519
                     /region_name="VASt"
                     /note="VAD1 Analog of StAR-related lipid transfer domain;
                     pfam16016"
                     /db_xref="CDD:464975"
     CDS             1..749
                     /gene="GRAMD1B"
                     /gene_synonym="LINC01059"
                     /coded_by="XM_054369475.1:415..2664"
                     /db_xref="GeneID:57476"
                     /db_xref="HGNC:HGNC:29214"
                     /db_xref="MIM:620179"
ORIGIN      
        1 masstasnsn rstpacspil rkrsrsptpq nqdgdtmvek gsdhssdksp stpeqgvqrs
       61 cssqsgrsgg knskksqswy nvlsptykqr nedfrklfkq lpdterlivd yscalqrdil
      121 lqgrlylsen wicfysnifr wetlltvrlk dicsmtkekt arlipnaiqv ctdsekhfft
      181 sfgardrtym mmfrlwqnal lekplcpkel whfvhqcygn elgltsdded yvppdddfnt
      241 mgyceeipve enevndsssk ssietkpdas pqlpkksitn stltstgsse apvsfdglpl
      301 eeealegdgs lekelaidni mgekiemiap vnspsldfnd nediptelsd ssdthdegev
      361 qafyedlsgr qyvnevfnfs vdklydllft nspfqrdfme qrrfsdiifh pwkkeengnq
      421 srvilytitl tnplapktat vretqtmyka sqesecyvid aevlthdvpy hdyfytinry
      481 tltrvarnks rlrvstelry rkqpwglvkt fieknfwsgl edyfrhlese laktestyla
      541 emhrqspkek asktttvrrr krphahlrvp hleevmspvt tptdedvghr ikhvagstqt
      601 rhipedtpng fhlqsvskll lviscvlvll vilnmmlfyk lwmleyttqt ltawqglrlq
      661 erlpqsqtew aqllesqqky hdtelqkwre iikssvmlld qvrcptfsac pglwergllp
      721 lccekdprly hhppdfslqf ilppghalf
//
LOCUS       XP_054225451             713 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Aster-B isoform X15 [Homo sapiens].
ACCESSION   XP_054225451
VERSION     XP_054225451.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369476.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..713
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..713
                     /product="protein Aster-B isoform X15"
                     /calculated_mol_wt=82434
     Region          67..160
                     /region_name="PH-GRAM_GRAMDC"
                     /note="GRAM domain-containing protein (GRAMDC) Pleckstrin
                     Homology-Glucosyltransferases, Rab-like GTPase activators
                     and Myotubularins (PH-GRAM) domain; cd13220"
                     /db_xref="CDD:275406"
     Region          337..483
                     /region_name="VASt"
                     /note="VAD1 Analog of StAR-related lipid transfer domain;
                     pfam16016"
                     /db_xref="CDD:464975"
     CDS             1..713
                     /gene="GRAMD1B"
                     /gene_synonym="LINC01059"
                     /coded_by="XM_054369476.1:264..2405"
                     /db_xref="GeneID:57476"
                     /db_xref="HGNC:HGNC:29214"
                     /db_xref="MIM:620179"
ORIGIN      
        1 mvekgsdhss dkspstpeqg vqrscssqsg rsggknskks qswynvlspt ykqrnedfrk
       61 lfkqlpdter livdyscalq rdillqgrly lsenwicfys nifrwetllt vrlkdicsmt
      121 kektarlipn aiqvctdsek hfftsfgard rtymmmfrlw qnallekplc pkelwhfvhq
      181 cygnelglts ddedyvppdd dfntmgycee ipveenevnd ssskssietk pdaspqlpkk
      241 sitnstltst gsseapvsfd glpleeeale gdgslekela idnimgekie miapvnspsl
      301 dfndnedipt elsdssdthd egevqafyed lsgrqyvnev fnfsvdklyd llftnspfqr
      361 dfmeqrrfsd iifhpwkkee ngnqsrvily titltnplap ktatvretqt mykasqesec
      421 yvidaevlth dvpyhdyfyt inrytltrva rnksrlrvst elryrkqpwg lvktfieknf
      481 wsgledyfrh leselaktes tylaemhrqs pkekaskttt vrrrkrphah lrvphleevm
      541 spvttptded vghrikhvag stqtrhiped tpngfhlqsv sklllviscv lvllvilnmm
      601 lfyklwmley ttqtltawqg lrlqerlpqs qtewaqlles qqkyhdtelq kwreiikssv
      661 mlldqvrcpt fsacpglwer gllplccekd prlyhhppdf slqfilppgh alf
//
LOCUS       XP_054225452             713 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Aster-B isoform X15 [Homo sapiens].
ACCESSION   XP_054225452
VERSION     XP_054225452.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369477.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..713
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..713
                     /product="protein Aster-B isoform X15"
                     /calculated_mol_wt=82434
     Region          67..160
                     /region_name="PH-GRAM_GRAMDC"
                     /note="GRAM domain-containing protein (GRAMDC) Pleckstrin
                     Homology-Glucosyltransferases, Rab-like GTPase activators
                     and Myotubularins (PH-GRAM) domain; cd13220"
                     /db_xref="CDD:275406"
     Region          337..483
                     /region_name="VASt"
                     /note="VAD1 Analog of StAR-related lipid transfer domain;
                     pfam16016"
                     /db_xref="CDD:464975"
     CDS             1..713
                     /gene="GRAMD1B"
                     /gene_synonym="LINC01059"
                     /coded_by="XM_054369477.1:1166..3307"
                     /db_xref="GeneID:57476"
                     /db_xref="HGNC:HGNC:29214"
                     /db_xref="MIM:620179"
ORIGIN      
        1 mvekgsdhss dkspstpeqg vqrscssqsg rsggknskks qswynvlspt ykqrnedfrk
       61 lfkqlpdter livdyscalq rdillqgrly lsenwicfys nifrwetllt vrlkdicsmt
      121 kektarlipn aiqvctdsek hfftsfgard rtymmmfrlw qnallekplc pkelwhfvhq
      181 cygnelglts ddedyvppdd dfntmgycee ipveenevnd ssskssietk pdaspqlpkk
      241 sitnstltst gsseapvsfd glpleeeale gdgslekela idnimgekie miapvnspsl
      301 dfndnedipt elsdssdthd egevqafyed lsgrqyvnev fnfsvdklyd llftnspfqr
      361 dfmeqrrfsd iifhpwkkee ngnqsrvily titltnplap ktatvretqt mykasqesec
      421 yvidaevlth dvpyhdyfyt inrytltrva rnksrlrvst elryrkqpwg lvktfieknf
      481 wsgledyfrh leselaktes tylaemhrqs pkekaskttt vrrrkrphah lrvphleevm
      541 spvttptded vghrikhvag stqtrhiped tpngfhlqsv sklllviscv lvllvilnmm
      601 lfyklwmley ttqtltawqg lrlqerlpqs qtewaqlles qqkyhdtelq kwreiikssv
      661 mlldqvrcpt fsacpglwer gllplccekd prlyhhppdf slqfilppgh alf
//
LOCUS       XP_054225453             713 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Aster-B isoform X15 [Homo sapiens].
ACCESSION   XP_054225453
VERSION     XP_054225453.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369478.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..713
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..713
                     /product="protein Aster-B isoform X15"
                     /calculated_mol_wt=82434
     Region          67..160
                     /region_name="PH-GRAM_GRAMDC"
                     /note="GRAM domain-containing protein (GRAMDC) Pleckstrin
                     Homology-Glucosyltransferases, Rab-like GTPase activators
                     and Myotubularins (PH-GRAM) domain; cd13220"
                     /db_xref="CDD:275406"
     Region          337..483
                     /region_name="VASt"
                     /note="VAD1 Analog of StAR-related lipid transfer domain;
                     pfam16016"
                     /db_xref="CDD:464975"
     CDS             1..713
                     /gene="GRAMD1B"
                     /gene_synonym="LINC01059"
                     /coded_by="XM_054369478.1:220..2361"
                     /db_xref="GeneID:57476"
                     /db_xref="HGNC:HGNC:29214"
                     /db_xref="MIM:620179"
ORIGIN      
        1 mvekgsdhss dkspstpeqg vqrscssqsg rsggknskks qswynvlspt ykqrnedfrk
       61 lfkqlpdter livdyscalq rdillqgrly lsenwicfys nifrwetllt vrlkdicsmt
      121 kektarlipn aiqvctdsek hfftsfgard rtymmmfrlw qnallekplc pkelwhfvhq
      181 cygnelglts ddedyvppdd dfntmgycee ipveenevnd ssskssietk pdaspqlpkk
      241 sitnstltst gsseapvsfd glpleeeale gdgslekela idnimgekie miapvnspsl
      301 dfndnedipt elsdssdthd egevqafyed lsgrqyvnev fnfsvdklyd llftnspfqr
      361 dfmeqrrfsd iifhpwkkee ngnqsrvily titltnplap ktatvretqt mykasqesec
      421 yvidaevlth dvpyhdyfyt inrytltrva rnksrlrvst elryrkqpwg lvktfieknf
      481 wsgledyfrh leselaktes tylaemhrqs pkekaskttt vrrrkrphah lrvphleevm
      541 spvttptded vghrikhvag stqtrhiped tpngfhlqsv sklllviscv lvllvilnmm
      601 lfyklwmley ttqtltawqg lrlqerlpqs qtewaqlles qqkyhdtelq kwreiikssv
      661 mlldqvrcpt fsacpglwer gllplccekd prlyhhppdf slqfilppgh alf
//
LOCUS       XP_054225454             702 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Aster-B isoform X16 [Homo sapiens].
ACCESSION   XP_054225454
VERSION     XP_054225454.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369479.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..702
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..702
                     /product="protein Aster-B isoform X16"
                     /calculated_mol_wt=81691
     Region          71..164
                     /region_name="PH-GRAM_GRAMDC"
                     /note="GRAM domain-containing protein (GRAMDC) Pleckstrin
                     Homology-Glucosyltransferases, Rab-like GTPase activators
                     and Myotubularins (PH-GRAM) domain; cd13220"
                     /db_xref="CDD:275406"
     Region          341..487
                     /region_name="VASt"
                     /note="VAD1 Analog of StAR-related lipid transfer domain;
                     pfam16016"
                     /db_xref="CDD:464975"
     CDS             1..702
                     /gene="GRAMD1B"
                     /gene_synonym="LINC01059"
                     /coded_by="XM_054369479.1:1697..3805"
                     /db_xref="GeneID:57476"
                     /db_xref="HGNC:HGNC:29214"
                     /db_xref="MIM:620179"
ORIGIN      
        1 mesltesgvl wsllleqesq llqwylkqlg hapaaaehrc whgseeipav lsptykqrne
       61 dfrklfkqlp dterlivdys calqrdillq grlylsenwi cfysnifrwe tlltvrlkdi
      121 csmtkektar lipnaiqvct dsekhfftsf gardrtymmm frlwqnalle kplcpkelwh
      181 fvhqcygnel gltsddedyv ppdddfntmg yceeipveen evndssskss ietkpdaspq
      241 lpkksitnst ltstgsseap vsfdglplee ealegdgsle kelaidnimg ekiemiapvn
      301 spsldfndne diptelsdss dthdegevqa fyedlsgrqy vnevfnfsvd klydllftns
      361 pfqrdfmeqr rfsdiifhpw kkeengnqsr vilytitltn plapktatvr etqtmykasq
      421 esecyvidae vlthdvpyhd yfytinrytl trvarnksrl rvstelryrk qpwglvktfi
      481 eknfwsgled yfrhlesela ktestylaem hrqspkekas ktttvrrrkr phahlrvphl
      541 eevmspvttp tdedvghrik hvagstqtrh ipedtpngfh lqsvsklllv iscvicfslv
      601 llvilnmmlf yklwmleytt qtltawqglr lqerlpqsqt ewaqllesqq kyhdtelqkw
      661 reiikssvml ldqmkdslin lqngirsrdy tseseekrnr yh
//
LOCUS       XP_054225455             698 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Aster-B isoform X17 [Homo sapiens].
ACCESSION   XP_054225455
VERSION     XP_054225455.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369480.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..698
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..698
                     /product="protein Aster-B isoform X17"
                     /calculated_mol_wt=81240
     Region          71..164
                     /region_name="PH-GRAM_GRAMDC"
                     /note="GRAM domain-containing protein (GRAMDC) Pleckstrin
                     Homology-Glucosyltransferases, Rab-like GTPase activators
                     and Myotubularins (PH-GRAM) domain; cd13220"
                     /db_xref="CDD:275406"
     Region          341..487
                     /region_name="VASt"
                     /note="VAD1 Analog of StAR-related lipid transfer domain;
                     pfam16016"
                     /db_xref="CDD:464975"
     CDS             1..698
                     /gene="GRAMD1B"
                     /gene_synonym="LINC01059"
                     /coded_by="XM_054369480.1:1697..3793"
                     /db_xref="GeneID:57476"
                     /db_xref="HGNC:HGNC:29214"
                     /db_xref="MIM:620179"
ORIGIN      
        1 mesltesgvl wsllleqesq llqwylkqlg hapaaaehrc whgseeipav lsptykqrne
       61 dfrklfkqlp dterlivdys calqrdillq grlylsenwi cfysnifrwe tlltvrlkdi
      121 csmtkektar lipnaiqvct dsekhfftsf gardrtymmm frlwqnalle kplcpkelwh
      181 fvhqcygnel gltsddedyv ppdddfntmg yceeipveen evndssskss ietkpdaspq
      241 lpkksitnst ltstgsseap vsfdglplee ealegdgsle kelaidnimg ekiemiapvn
      301 spsldfndne diptelsdss dthdegevqa fyedlsgrqy vnevfnfsvd klydllftns
      361 pfqrdfmeqr rfsdiifhpw kkeengnqsr vilytitltn plapktatvr etqtmykasq
      421 esecyvidae vlthdvpyhd yfytinrytl trvarnksrl rvstelryrk qpwglvktfi
      481 eknfwsgled yfrhlesela ktestylaem hrqspkekas ktttvrrrkr phahlrvphl
      541 eevmspvttp tdedvghrik hvagstqtrh ipedtpngfh lqsvsklllv iscvlvllvi
      601 lnmmlfyklw mleyttqtlt awqglrlqer lpqsqtewaq llesqqkyhd telqkwreii
      661 kssvmlldqm kdslinlqng irsrdytses eekrnryh
//
LOCUS       XP_054225456             694 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Aster-B isoform X25 [Homo sapiens].
ACCESSION   XP_054225456
VERSION     XP_054225456.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369481.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..694
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..694
                     /product="protein Aster-B isoform X25"
                     /calculated_mol_wt=80498
     Region          67..160
                     /region_name="PH-GRAM_GRAMDC"
                     /note="GRAM domain-containing protein (GRAMDC) Pleckstrin
                     Homology-Glucosyltransferases, Rab-like GTPase activators
                     and Myotubularins (PH-GRAM) domain; cd13220"
                     /db_xref="CDD:275406"
     Region          337..483
                     /region_name="VASt"
                     /note="VAD1 Analog of StAR-related lipid transfer domain;
                     pfam16016"
                     /db_xref="CDD:464975"
     CDS             1..694
                     /gene="GRAMD1B"
                     /gene_synonym="LINC01059"
                     /coded_by="XM_054369481.1:719..2803"
                     /db_xref="GeneID:57476"
                     /db_xref="HGNC:HGNC:29214"
                     /db_xref="MIM:620179"
ORIGIN      
        1 mvekgsdhss dkspstpeqg vqrscssqsg rsggknskks qswynvlspt ykqrnedfrk
       61 lfkqlpdter livdyscalq rdillqgrly lsenwicfys nifrwetllt vrlkdicsmt
      121 kektarlipn aiqvctdsek hfftsfgard rtymmmfrlw qnallekplc pkelwhfvhq
      181 cygnelglts ddedyvppdd dfntmgycee ipveenevnd ssskssietk pdaspqlpkk
      241 sitnstltst gsseapvsfd glpleeeale gdgslekela idnimgekie miapvnspsl
      301 dfndnedipt elsdssdthd egevqafyed lsgrqyvnev fnfsvdklyd llftnspfqr
      361 dfmeqrrfsd iifhpwkkee ngnqsrvily titltnplap ktatvretqt mykasqesec
      421 yvidaevlth dvpyhdyfyt inrytltrva rnksrlrvst elryrkqpwg lvktfieknf
      481 wsgledyfrh leselaktes tylaemhrqs pkekaskttt vrrrkrphah lrvphleevm
      541 spvttptded vghrikhvag stqtrhiped tpngfhlqsv sklllviscv lvllvilnmm
      601 lfyklwmley ttqtltawqg lrlqerlpqs qtewaqlles qqkyhdtelq kwreiikssv
      661 mlldqmkdsl inlqngirsr dytseseekr nryh
//
LOCUS       XP_054225457             580 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Aster-B isoform X26 [Homo sapiens].
ACCESSION   XP_054225457
VERSION     XP_054225457.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369482.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..580
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..580
                     /product="protein Aster-B isoform X26"
                     /calculated_mol_wt=67275
     Region          <1..42
                     /region_name="PH-like"
                     /note="Pleckstrin homology-like domain; cl17171"
                     /db_xref="CDD:473070"
     Region          219..365
                     /region_name="VASt"
                     /note="VAD1 Analog of StAR-related lipid transfer domain;
                     pfam16016"
                     /db_xref="CDD:464975"
     CDS             1..580
                     /gene="GRAMD1B"
                     /gene_synonym="LINC01059"
                     /coded_by="XM_054369482.1:351..2093"
                     /db_xref="GeneID:57476"
                     /db_xref="HGNC:HGNC:29214"
                     /db_xref="MIM:620179"
ORIGIN      
        1 mtkektarli pnaiqvctds ekhfftsfga rdrtymmmfr lwqnallekp lcpkelwhfv
       61 hqcygnelgl tsddedyvpp dddfntmgyc eeipveenev ndssskssie tkpdaspqlp
      121 kksitnstlt stgsseapvs fdglpleeea legdgsleke laidnimgek iemiapvnsp
      181 sldfndnedi ptelsdssdt hdegevqafy edlsgrqyvn evfnfsvdkl ydllftnspf
      241 qrdfmeqrrf sdiifhpwkk eengnqsrvi lytitltnpl apktatvret qtmykasqes
      301 ecyvidaevl thdvpyhdyf ytinrytltr varnksrlrv stelryrkqp wglvktfiek
      361 nfwsgledyf rhleselakt estylaemhr qspkekaskt ttvrrrkrph ahlrvphlee
      421 vmspvttptd edvghrikhv agstqtrhip edtpngfhlq svsklllvis cvicfslvll
      481 vilnmmlfyk lwmleyttqt ltawqglrlq erlpqsqtew aqllesqqky hdtelqkwre
      541 iikssvmlld qmkdslinlq ngirsrdyts eseekrnryh
//
LOCUS       XP_054225458            1018 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin carboxyl-terminal hydrolase 35 isoform X1 [Homo sapiens].
ACCESSION   XP_054225458
VERSION     XP_054225458.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369483.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1018
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1018
                     /product="ubiquitin carboxyl-terminal hydrolase 35 isoform
                     X1"
                     /calculated_mol_wt=113286
     Region          <55..97
                     /region_name="COG1365"
                     /note="Predicted ATPase, PP-loop superfamily [General
                     function prediction only]"
                     /db_xref="CDD:440976"
     Region          442..924
                     /region_name="Peptidase_C19"
                     /note="Peptidase C19 contains ubiquitinyl hydrolases. They
                     are intracellular peptidases that remove ubiquitin
                     molecules from polyubiquinated peptides by cleavage of
                     isopeptide bonds. They hydrolyse bonds involving the
                     carboxyl group of the C-terminal Gly...; cl02553"
                     /db_xref="CDD:470612"
     Site            order(445,450,862,895)
                     /site_type="active"
                     /db_xref="CDD:239072"
     CDS             1..1018
                     /gene="USP35"
                     /coded_by="XM_054369483.1:250..3306"
                     /db_xref="GeneID:57558"
                     /db_xref="HGNC:HGNC:20061"
                     /db_xref="MIM:620959"
ORIGIN      
        1 mdkileavvt ssypvsvkqg lvrrvleaar qplereqcla llalgarlyv ggaeelprrv
       61 gcqllhvagr hhpdvfaeff sarrvlrllq ggagppgpra lacvqlglql lpegpaadev
      121 fallrrevlr tvcerpgpaa caqvarllar hprcvpdgph rllfcqqlvr clgrfrcpae
      181 geegavefle qaqqvsglla qlwraqpaai lpclkelfav iscaeeepps salasvvqhl
      241 plelmdgvvr nlsnddsvtd sqmltaisrm idwvswplgk nidkwiiall kglaavkkfs
      301 ilievsltki ekvfskllyp ivrgaalsvl kymlltfqhs heafhlllph ippmvaslvk
      361 edsnsgtscl eqlaelvhcm vfrfpgfpdl yepvmeaikd lhvpnedrik qllgqdawts
      421 qkselagfyp rlmaksdtgk iglinlgntc yvnsilqalf masdfrhcvl rltennsqpl
      481 mtklqwlfgf lehsqrpais penflsaswt pwfspgtqqd cseylkylld rlheeektgt
      541 ricqklkqss spsppeeppa psstsvekmf ggkivtricc lcclnvssre eaftdlslaf
      601 pppercrrrr lgsvmrpted itarelpppt saqgpgrvgp rrqrkhcite dtpptslyie
      661 gldskeaggq ssqeervere eegkeertek eevgeeeest rgegerekee eveeeeekve
      721 ketekeaeqe keedslgagt hpdaaipsge rtcgsegsrs vldlvnyfls pekltaenry
      781 ycescaslqd aekvvelsqg pcyliltllr fsfdlrtmrr rkilddvsip lllrlplagg
      841 rgqaydlcsv vvhsgvsses ghyycyareg aarpapslgt adrpepenqw ylfndtrvsf
      901 ssfesvsnvt sffpkdtayv lfyrqrpreg peaelgssrv rteptlhkdl meaiskdnil
      961 ylqeqekear sraayisalp tsphwgrgfd edkdedegsp ggcnpaggng gdfhrlvf
//
LOCUS       XP_054225459            1018 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin carboxyl-terminal hydrolase 35 isoform X1 [Homo sapiens].
ACCESSION   XP_054225459
VERSION     XP_054225459.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369484.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1018
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1018
                     /product="ubiquitin carboxyl-terminal hydrolase 35 isoform
                     X1"
                     /calculated_mol_wt=113286
     Region          <55..97
                     /region_name="COG1365"
                     /note="Predicted ATPase, PP-loop superfamily [General
                     function prediction only]"
                     /db_xref="CDD:440976"
     Region          442..924
                     /region_name="Peptidase_C19"
                     /note="Peptidase C19 contains ubiquitinyl hydrolases. They
                     are intracellular peptidases that remove ubiquitin
                     molecules from polyubiquinated peptides by cleavage of
                     isopeptide bonds. They hydrolyse bonds involving the
                     carboxyl group of the C-terminal Gly...; cl02553"
                     /db_xref="CDD:470612"
     Site            order(445,450,862,895)
                     /site_type="active"
                     /db_xref="CDD:239072"
     CDS             1..1018
                     /gene="USP35"
                     /coded_by="XM_054369484.1:250..3306"
                     /db_xref="GeneID:57558"
                     /db_xref="HGNC:HGNC:20061"
                     /db_xref="MIM:620959"
ORIGIN      
        1 mdkileavvt ssypvsvkqg lvrrvleaar qplereqcla llalgarlyv ggaeelprrv
       61 gcqllhvagr hhpdvfaeff sarrvlrllq ggagppgpra lacvqlglql lpegpaadev
      121 fallrrevlr tvcerpgpaa caqvarllar hprcvpdgph rllfcqqlvr clgrfrcpae
      181 geegavefle qaqqvsglla qlwraqpaai lpclkelfav iscaeeepps salasvvqhl
      241 plelmdgvvr nlsnddsvtd sqmltaisrm idwvswplgk nidkwiiall kglaavkkfs
      301 ilievsltki ekvfskllyp ivrgaalsvl kymlltfqhs heafhlllph ippmvaslvk
      361 edsnsgtscl eqlaelvhcm vfrfpgfpdl yepvmeaikd lhvpnedrik qllgqdawts
      421 qkselagfyp rlmaksdtgk iglinlgntc yvnsilqalf masdfrhcvl rltennsqpl
      481 mtklqwlfgf lehsqrpais penflsaswt pwfspgtqqd cseylkylld rlheeektgt
      541 ricqklkqss spsppeeppa psstsvekmf ggkivtricc lcclnvssre eaftdlslaf
      601 pppercrrrr lgsvmrpted itarelpppt saqgpgrvgp rrqrkhcite dtpptslyie
      661 gldskeaggq ssqeervere eegkeertek eevgeeeest rgegerekee eveeeeekve
      721 ketekeaeqe keedslgagt hpdaaipsge rtcgsegsrs vldlvnyfls pekltaenry
      781 ycescaslqd aekvvelsqg pcyliltllr fsfdlrtmrr rkilddvsip lllrlplagg
      841 rgqaydlcsv vvhsgvsses ghyycyareg aarpapslgt adrpepenqw ylfndtrvsf
      901 ssfesvsnvt sffpkdtayv lfyrqrpreg peaelgssrv rteptlhkdl meaiskdnil
      961 ylqeqekear sraayisalp tsphwgrgfd edkdedegsp ggcnpaggng gdfhrlvf
//
LOCUS       XP_054225460             749 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin carboxyl-terminal hydrolase 35 isoform X2 [Homo sapiens].
ACCESSION   XP_054225460
VERSION     XP_054225460.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369485.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..749
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..749
                     /product="ubiquitin carboxyl-terminal hydrolase 35 isoform
                     X2"
                     /calculated_mol_wt=84070
     Region          173..655
                     /region_name="Peptidase_C19"
                     /note="Peptidase C19 contains ubiquitinyl hydrolases. They
                     are intracellular peptidases that remove ubiquitin
                     molecules from polyubiquinated peptides by cleavage of
                     isopeptide bonds. They hydrolyse bonds involving the
                     carboxyl group of the C-terminal Gly...; cl02553"
                     /db_xref="CDD:470612"
     Site            order(176,181,593,626)
                     /site_type="active"
                     /db_xref="CDD:239072"
     CDS             1..749
                     /gene="USP35"
                     /coded_by="XM_054369485.1:93..2342"
                     /db_xref="GeneID:57558"
                     /db_xref="HGNC:HGNC:20061"
                     /db_xref="MIM:620959"
ORIGIN      
        1 midwvswplg knidkwiial lkglaavkkf silievsltk iekvfsklly pivrgaalsv
       61 lkymlltfqh sheafhlllp hippmvaslv kedsnsgtsc leqlaelvhc mvfrfpgfpd
      121 lyepvmeaik dlhvpnedri kqllgqdawt sqkselagfy prlmaksdtg kiglinlgnt
      181 cyvnsilqal fmasdfrhcv lrltennsqp lmtklqwlfg flehsqrpai spenflsasw
      241 tpwfspgtqq dcseylkyll drlheeektg tricqklkqs sspsppeepp apsstsvekm
      301 fggkivtric clcclnvssr eeaftdlsla fpppercrrr rlgsvmrpte ditarelppp
      361 tsaqgpgrvg prrqrkhcit edtpptslyi egldskeagg qssqeerver eeegkeerte
      421 keevgeeees trgegereke eeveeeeekv eketekeaeq ekeedslgag thpdaaipsg
      481 ertcgsegsr svldlvnyfl spekltaenr yycescaslq daekvvelsq gpcyliltll
      541 rfsfdlrtmr rrkilddvsi plllrlplag grgqaydlcs vvvhsgvsse sghyycyare
      601 gaarpapslg tadrpepenq wylfndtrvs fssfesvsnv tsffpkdtay vlfyrqrpre
      661 gpeaelgssr vrteptlhkd lmeaiskdni lylqeqekea rsraayisal ptsphwgrgf
      721 dedkdedegs pggcnpaggn ggdfhrlvf
//
LOCUS       XP_054225461             749 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin carboxyl-terminal hydrolase 35 isoform X2 [Homo sapiens].
ACCESSION   XP_054225461
VERSION     XP_054225461.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369486.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..749
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..749
                     /product="ubiquitin carboxyl-terminal hydrolase 35 isoform
                     X2"
                     /calculated_mol_wt=84070
     Region          173..655
                     /region_name="Peptidase_C19"
                     /note="Peptidase C19 contains ubiquitinyl hydrolases. They
                     are intracellular peptidases that remove ubiquitin
                     molecules from polyubiquinated peptides by cleavage of
                     isopeptide bonds. They hydrolyse bonds involving the
                     carboxyl group of the C-terminal Gly...; cl02553"
                     /db_xref="CDD:470612"
     Site            order(176,181,593,626)
                     /site_type="active"
                     /db_xref="CDD:239072"
     CDS             1..749
                     /gene="USP35"
                     /coded_by="XM_054369486.1:90..2339"
                     /db_xref="GeneID:57558"
                     /db_xref="HGNC:HGNC:20061"
                     /db_xref="MIM:620959"
ORIGIN      
        1 midwvswplg knidkwiial lkglaavkkf silievsltk iekvfsklly pivrgaalsv
       61 lkymlltfqh sheafhlllp hippmvaslv kedsnsgtsc leqlaelvhc mvfrfpgfpd
      121 lyepvmeaik dlhvpnedri kqllgqdawt sqkselagfy prlmaksdtg kiglinlgnt
      181 cyvnsilqal fmasdfrhcv lrltennsqp lmtklqwlfg flehsqrpai spenflsasw
      241 tpwfspgtqq dcseylkyll drlheeektg tricqklkqs sspsppeepp apsstsvekm
      301 fggkivtric clcclnvssr eeaftdlsla fpppercrrr rlgsvmrpte ditarelppp
      361 tsaqgpgrvg prrqrkhcit edtpptslyi egldskeagg qssqeerver eeegkeerte
      421 keevgeeees trgegereke eeveeeeekv eketekeaeq ekeedslgag thpdaaipsg
      481 ertcgsegsr svldlvnyfl spekltaenr yycescaslq daekvvelsq gpcyliltll
      541 rfsfdlrtmr rrkilddvsi plllrlplag grgqaydlcs vvvhsgvsse sghyycyare
      601 gaarpapslg tadrpepenq wylfndtrvs fssfesvsnv tsffpkdtay vlfyrqrpre
      661 gpeaelgssr vrteptlhkd lmeaiskdni lylqeqekea rsraayisal ptsphwgrgf
      721 dedkdedegs pggcnpaggn ggdfhrlvf
//
LOCUS       XP_054225462             734 aa            linear   PRI 05-AUG-2025
DEFINITION  rho GTPase-activating protein 20 isoform X1 [Homo sapiens].
ACCESSION   XP_054225462
VERSION     XP_054225462.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369487.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..734
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..734
                     /product="rho GTPase-activating protein 20 isoform X1"
                     /calculated_mol_wt=81180
     Region          <1..98
                     /region_name="RhoGAP"
                     /note="GTPase-activator protein (GAP) for Rho-like
                     GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases.
                     Small GTPases (G proteins) cluster into distinct families,
                     and all act as molecular switches, active in their
                     GTP-bound form but inactive when bound to...; cl02570"
                     /db_xref="CDD:470621"
     CDS             1..734
                     /gene="ARHGAP20"
                     /gene_synonym="RARHOGAP"
                     /coded_by="XM_054369487.1:532..2736"
                     /db_xref="GeneID:57569"
                     /db_xref="HGNC:HGNC:18357"
                     /db_xref="MIM:609568"
ORIGIN      
        1 mdqgndeeki ntvqrlldql pranvvllry lfgvlhnieq hsssnqmtaf nlavcvapsi
       61 lwppassspe leneftkkvs lliqflienc lrifgeeits lfrevsvrcd trenasdisc
      121 fqlndssyds lenelnedvd apcsdlvkkl gqgsrsmdsv ltlsdydldq peveglltls
      181 dfdlahskde dvqmkrples kpvnilvytk iplrdharap samctpsyls taaanaaksl
      241 rrhrrcseps idyldsklsy lrefyqkklr ksscdailsq kdedylkqnq plqeegktcf
      301 kqslvtgtdv skknattqnt kkkslsgseg nhvklfpksk pvaisvasys pmssqdhskn
      361 qpfdvntsgy spphtadalk gprthrrcse pniedqnrkl tylrgiyskk qhktsceagl
      421 lhgeedylkr hkslqmegqk linqslvmgi evgkssatnq ntekvlpprl nlcprtsyss
      481 lsspgtspsg ssvssqdsaf sqisehsvft ptetsspidc tfqaqrkred lspdfsnash
      541 vsgmpgpssg qacsrpaytk kdtmewhsqm hsvtlhpstw lrngvaslkn wslkkkakaa
      601 rpeeekiasp kgplepppha sgvpeanslq eeqkdlplra aeglspvqsa qrcssspfqd
      661 serhcsspfs lvesrlklcm ksheeiepgs qsssgslpwe rasasswtle datspdsgpt
      721 vvcdiedryl tkdi
//
LOCUS       XP_054225463             282 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-13 isoform X1 [Homo sapiens].
ACCESSION   XP_054225463
VERSION     XP_054225463.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369488.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..282
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..282
                     /product="synaptotagmin-13 isoform X1"
                     /calculated_mol_wt=31188
     Region          16..133
                     /region_name="C2A_Synaptotagmin-13"
                     /note="C2 domain; cd08677"
                     /db_xref="CDD:176059"
     Region          144..281
                     /region_name="C2B_Synaptotagmin-13"
                     /note="C2 domain second repeat present in Synaptotagmin
                     13; cd08407"
                     /db_xref="CDD:176052"
     CDS             1..282
                     /gene="SYT13"
                     /coded_by="XM_054369488.1:274..1122"
                     /db_xref="GeneID:57586"
                     /db_xref="HGNC:HGNC:14962"
                     /db_xref="MIM:607716"
ORIGIN      
        1 metwnpekaa swnqapklhy cldydcqkae lfvtrleavt snhdggcdcy vqgsvanrtg
       61 sveaqtalkk rqlhttweeg lvlplaeeel ptatltltlr tcdrfsrhsv agelrlgldg
      121 tsvplgaaqw gelktsakep sagagevlls isylpaanrl lvvlikaknl hsnqskellg
      181 kdvsvkvtlk hqarklkkkq tkrakhkinp vwnemimfel pddllqassv elevlgqdds
      241 gqscalghcs lglhtsgser shweemlknp rrqiamwhql hl
//
LOCUS       XP_054225464             282 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-13 isoform X1 [Homo sapiens].
ACCESSION   XP_054225464
VERSION     XP_054225464.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369489.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..282
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..282
                     /product="synaptotagmin-13 isoform X1"
                     /calculated_mol_wt=31188
     Region          16..133
                     /region_name="C2A_Synaptotagmin-13"
                     /note="C2 domain; cd08677"
                     /db_xref="CDD:176059"
     Region          144..281
                     /region_name="C2B_Synaptotagmin-13"
                     /note="C2 domain second repeat present in Synaptotagmin
                     13; cd08407"
                     /db_xref="CDD:176052"
     CDS             1..282
                     /gene="SYT13"
                     /coded_by="XM_054369489.1:274..1122"
                     /db_xref="GeneID:57586"
                     /db_xref="HGNC:HGNC:14962"
                     /db_xref="MIM:607716"
ORIGIN      
        1 metwnpekaa swnqapklhy cldydcqkae lfvtrleavt snhdggcdcy vqgsvanrtg
       61 sveaqtalkk rqlhttweeg lvlplaeeel ptatltltlr tcdrfsrhsv agelrlgldg
      121 tsvplgaaqw gelktsakep sagagevlls isylpaanrl lvvlikaknl hsnqskellg
      181 kdvsvkvtlk hqarklkkkq tkrakhkinp vwnemimfel pddllqassv elevlgqdds
      241 gqscalghcs lglhtsgser shweemlknp rrqiamwhql hl
//
LOCUS       XP_054225465            1649 aa            linear   PRI 05-AUG-2025
DEFINITION  PHD and RING finger domain-containing protein 1 isoform X16 [Homo
            sapiens].
ACCESSION   XP_054225465
VERSION     XP_054225465.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369490.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1649
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1649
                     /product="PHD and RING finger domain-containing protein 1
                     isoform X16"
                     /calculated_mol_wt=178508
     Region          <49..106
                     /region_name="DNA_pol_phi"
                     /note="DNA polymerase phi; pfam04931"
                     /db_xref="CDD:461488"
     Region          102..152
                     /region_name="mRING-HC-C3HC3D_PHRF1"
                     /note="Modified RING finger, HC subclass (C3HC3D-type),
                     found in PHD and RING finger domain-containing protein 1
                     (PHRF1) and similar proteins; cd16635"
                     /db_xref="CDD:438297"
     Region          185..230
                     /region_name="PHD_PHRF1"
                     /note="PHD finger found in PHD and RING finger
                     domain-containing protein 1 (PHRF1); cd15536"
                     /db_xref="CDD:277011"
     Site            order(185,197..201,205,225)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277011"
     Region          <1289..1555
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..1649
                     /gene="PHRF1"
                     /gene_synonym="PPP1R125; RNF221"
                     /coded_by="XM_054369490.1:3966..8915"
                     /db_xref="GeneID:57661"
                     /db_xref="HGNC:HGNC:24351"
                     /db_xref="MIM:611780"
ORIGIN      
        1 mdddsldelv arspgpdghp qvgpadpagd feessvgssg dsgddsdseh gdgtdgedeg
       61 aseeedledr sgsedseddg etllevagtq gkleaagsfn sdddaescpi clnafrdqav
      121 gtpencahyf cldcivewsk nanscpvdrt lfkciciraq fggkilrkip ventkaseee
      181 edptfcevcg rsdredrlll cdgcdagyhm ecldpplqev pvdewfcpec aapgvvlaad
      241 agpvseeevs llladvvptt srlrpragrt raiartrqse rvratvnrnr istarrvqht
      301 pgrlgsslld eaieavatgl stavyqrplt prtparrkrk trrrkkvpgr kktpsgpsak
      361 skssatrskk rqhrvkkrrg kkvkseattr sriartlglr rpvhsscips vlkpvepslg
      421 llradigaas lslfgdpyel dpfdsseels anplsplsak rralsrsalq shqpvarpvs
      481 vglsrrrlpa avpepdleee pvpdllgsil sgqsllmlgs sdviihrdgs lsakraapvs
      541 fqrnsgslsr geegfkgclq pralpsgspa qgpsgnrpqs tglscqgrsr tpartagapv
      601 rldlpaapga vqarnlsngs vpgfrqshsp wfngtnkhtl plasaaskis srdskppcrs
      661 vvpgpplkpa prrtdiselp ripkirrddg ggrrdaapah gqsieipsac isrltgregt
      721 gqpgrgtrae seassrvpre pgvhtgssrp papsshgsla plgpsrgkgv gstfesfrin
      781 ipgnmahssq lsspgfcntf rpvddkeqrk enpsplfsik ktkqlrsevy dpsdptgsds
      841 sapgsspers gpgllpseit rtisinspka qtvqavrcvt sytvesifgt epepplgpss
      901 amsklrgava aegasdtere eptesqglaa rlrrpsppep wdeedgascs tffgseertv
      961 tcvtvvepea ppspdvlqaa thrvvelrpp srsrstsssr srkkakrkrv srehgrtrsg
     1021 trsesrdrss rsaspsvgee rprrqrskak srrsssdrss srerakrkka kdksrehrrg
     1081 pwghsrrtsr srsgspgsss yehyesrkkk krrsasrprg recsptssle rlcrhkhqre
     1141 rsherpdrke svawprdrrk rrsrspsseh rarehrrprs rekwpqtrsh sperkgavre
     1201 aspaplaqge pgredlptrl palgeahvsp evatadkapl qappvlevaa ecepddldld
     1261 ygdsveaghv fddfssdavf iqlddmsspp spestdsspe rdfplkpalp paslavaaiq
     1321 revslmhded psqppplpeg tqephllrpd aaekaeapss pdvapagked spsasgrvqe
     1381 aarpeevvsq tpllrsralv krvtwnlqes essapaedra praplhrpqk pregawdmed
     1441 vaptgvrqaf selpfpshvl pepgfpdtdp sqvyspglpp apaqpssipp calvsqptvq
     1501 filqgslplv gcgaaqtlap vpaaltpase pasqataasn seektpaprl aaektkkeey
     1561 mkklhmqera veevklaikp fyqkrevtke eykdilrkav qkichsksge inpvkvanlv
     1621 kayvdkyrhm rrhkkpeage epptqgaeg
//
LOCUS       XP_054225466            1648 aa            linear   PRI 05-AUG-2025
DEFINITION  PHD and RING finger domain-containing protein 1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225466
VERSION     XP_054225466.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369491.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1648
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1648
                     /product="PHD and RING finger domain-containing protein 1
                     isoform X1"
                     /calculated_mol_wt=178379
     Region          <48..105
                     /region_name="DNA_pol_phi"
                     /note="DNA polymerase phi; pfam04931"
                     /db_xref="CDD:461488"
     Region          101..151
                     /region_name="mRING-HC-C3HC3D_PHRF1"
                     /note="Modified RING finger, HC subclass (C3HC3D-type),
                     found in PHD and RING finger domain-containing protein 1
                     (PHRF1) and similar proteins; cd16635"
                     /db_xref="CDD:438297"
     Region          184..229
                     /region_name="PHD_PHRF1"
                     /note="PHD finger found in PHD and RING finger
                     domain-containing protein 1 (PHRF1); cd15536"
                     /db_xref="CDD:277011"
     Site            order(184,196..200,204,224)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277011"
     Region          <1288..1554
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..1648
                     /gene="PHRF1"
                     /gene_synonym="PPP1R125; RNF221"
                     /coded_by="XM_054369491.1:145..5091"
                     /db_xref="GeneID:57661"
                     /db_xref="HGNC:HGNC:24351"
                     /db_xref="MIM:611780"
ORIGIN      
        1 mdddsldelv arspgpdghp qvgpadpagd fessvgssgd sgddsdsehg dgtdgedega
       61 seeedledrs gsedseddge tllevagtqg kleaagsfns dddaescpic lnafrdqavg
      121 tpencahyfc ldcivewskn anscpvdrtl fkciciraqf ggkilrkipv entkaseeee
      181 dptfcevcgr sdredrlllc dgcdagyhme cldpplqevp vdewfcpeca apgvvlaada
      241 gpvseeevsl lladvvptts rlrpragrtr aiartrqser vratvnrnri starrvqhtp
      301 grlgssllde aieavatgls tavyqrpltp rtparrkrkt rrrkkvpgrk ktpsgpsaks
      361 kssatrskkr qhrvkkrrgk kvkseattrs riartlglrr pvhsscipsv lkpvepslgl
      421 lradigaasl slfgdpyeld pfdsseelsa nplsplsakr ralsrsalqs hqpvarpvsv
      481 glsrrrlpaa vpepdleeep vpdllgsils gqsllmlgss dviihrdgsl sakraapvsf
      541 qrnsgslsrg eegfkgclqp ralpsgspaq gpsgnrpqst glscqgrsrt partagapvr
      601 ldlpaapgav qarnlsngsv pgfrqshspw fngtnkhtlp lasaaskiss rdskppcrsv
      661 vpgpplkpap rrtdiselpr ipkirrddgg grrdaapahg qsieipsaci srltgregtg
      721 qpgrgtraes eassrvprep gvhtgssrpp apsshgslap lgpsrgkgvg stfesfrini
      781 pgnmahssql sspgfcntfr pvddkeqrke npsplfsikk tkqlrsevyd psdptgsdss
      841 apgsspersg pgllpseitr tisinspkaq tvqavrcvts ytvesifgte pepplgpssa
      901 msklrgavaa egasdteree ptesqglaar lrrpsppepw deedgascst ffgseertvt
      961 cvtvvepeap pspdvlqaat hrvvelrpps rsrstsssrs rkkakrkrvs rehgrtrsgt
     1021 rsesrdrssr saspsvgeer prrqrskaks rrsssdrsss rerakrkkak dksrehrrgp
     1081 wghsrrtsrs rsgspgsssy ehyesrkkkk rrsasrprgr ecsptssler lcrhkhqrer
     1141 sherpdrkes vawprdrrkr rsrspssehr arehrrprsr ekwpqtrshs perkgavrea
     1201 spaplaqgep gredlptrlp algeahvspe vatadkaplq appvlevaae cepddldldy
     1261 gdsveaghvf ddfssdavfi qlddmsspps pestdssper dfplkpalpp aslavaaiqr
     1321 evslmhdedp sqppplpegt qephllrpda aekaeapssp dvapagkeds psasgrvqea
     1381 arpeevvsqt pllrsralvk rvtwnlqese ssapaedrap raplhrpqkp regawdmedv
     1441 aptgvrqafs elpfpshvlp epgfpdtdps qvyspglppa paqpssippc alvsqptvqf
     1501 ilqgslplvg cgaaqtlapv paaltpasep asqataasns eektpaprla aektkkeeym
     1561 kklhmqerav eevklaikpf yqkrevtkee ykdilrkavq kichsksgei npvkvanlvk
     1621 ayvdkyrhmr rhkkpeagee pptqgaeg
//
LOCUS       XP_054225467            1647 aa            linear   PRI 05-AUG-2025
DEFINITION  PHD and RING finger domain-containing protein 1 isoform X2 [Homo
            sapiens].
ACCESSION   XP_054225467
VERSION     XP_054225467.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369492.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1647
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1647
                     /product="PHD and RING finger domain-containing protein 1
                     isoform X2"
                     /calculated_mol_wt=178280
     Region          <49..106
                     /region_name="DNA_pol_phi"
                     /note="DNA polymerase phi; pfam04931"
                     /db_xref="CDD:461488"
     Region          102..152
                     /region_name="mRING-HC-C3HC3D_PHRF1"
                     /note="Modified RING finger, HC subclass (C3HC3D-type),
                     found in PHD and RING finger domain-containing protein 1
                     (PHRF1) and similar proteins; cd16635"
                     /db_xref="CDD:438297"
     Region          185..230
                     /region_name="PHD_PHRF1"
                     /note="PHD finger found in PHD and RING finger
                     domain-containing protein 1 (PHRF1); cd15536"
                     /db_xref="CDD:277011"
     Site            order(185,197..201,205,225)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277011"
     Region          <1287..1553
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..1647
                     /gene="PHRF1"
                     /gene_synonym="PPP1R125; RNF221"
                     /coded_by="XM_054369492.1:145..5088"
                     /db_xref="GeneID:57661"
                     /db_xref="HGNC:HGNC:24351"
                     /db_xref="MIM:611780"
ORIGIN      
        1 mdddsldelv arspgpdghp qvgpadpagd feessvgssg dsgddsdseh gdgtdgedeg
       61 aseeedledr sgsedseddg etllevagtq gkleaagsfn sdddaescpi clnafrdqav
      121 gtpencahyf cldcivewsk nanscpvdrt lfkciciraq fggkilrkip ventkaseee
      181 edptfcevcg rsdredrlll cdgcdagyhm ecldpplqev pvdewfcpec aapgvvlaad
      241 agpvseeevs llladvvptt srlrpragrt raiartrqse rvratvnrnr istarrvqht
      301 pgrlgsslld eaieavatgl stavyqrplt prtparrkrk trrrkkvpgr kktpsgpsak
      361 skssatrskk rqhrvkkrrg kkseattrsr iartlglrrp vhsscipsvl kpvepslgll
      421 radigaasls lfgdpyeldp fdsseelsan plsplsakrr alsrsalqsh qpvarpvsvg
      481 lsrrrlpaav pepdleeepv pdllgsilsg qsllmlgssd viihrdgsls akraapvsfq
      541 rnsgslsrge egfkgclqpr alpsgspaqg psgnrpqstg lscqgrsrtp artagapvrl
      601 dlpaapgavq arnlsngsvp gfrqshspwf ngtnkhtlpl asaaskissr dskppcrsvv
      661 pgpplkpapr rtdiselpri pkirrddggg rrdaapahgq sieipsacis rltgregtgq
      721 pgrgtraese assrvprepg vhtgssrppa psshgslapl gpsrgkgvgs tfesfrinip
      781 gnmahssqls spgfcntfrp vddkeqrken psplfsikkt kqlrsevydp sdptgsdssa
      841 pgsspersgp gllpseitrt isinspkaqt vqavrcvtsy tvesifgtep epplgpssam
      901 sklrgavaae gasdtereep tesqglaarl rrpsppepwd eedgascstf fgseertvtc
      961 vtvvepeapp spdvlqaath rvvelrppsr srstsssrsr kkakrkrvsr ehgrtrsgtr
     1021 sesrdrssrs aspsvgeerp rrqrskaksr rsssdrsssr erakrkkakd ksrehrrgpw
     1081 ghsrrtsrsr sgspgsssye hyesrkkkkr rsasrprgre csptsslerl crhkhqrers
     1141 herpdrkesv awprdrrkrr srspssehra rehrrprsre kwpqtrshsp erkgavreas
     1201 paplaqgepg redlptrlpa lgeahvspev atadkaplqa ppvlevaaec epddldldyg
     1261 dsveaghvfd dfssdavfiq lddmssppsp estdssperd fplkpalppa slavaaiqre
     1321 vslmhdedps qppplpegtq ephllrpdaa ekaeapsspd vapagkedsp sasgrvqeaa
     1381 rpeevvsqtp llrsralvkr vtwnlqeses sapaedrapr aplhrpqkpr egawdmedva
     1441 ptgvrqafse lpfpshvlpe pgfpdtdpsq vyspglppap aqpssippca lvsqptvqfi
     1501 lqgslplvgc gaaqtlapvp aaltpasepa sqataasnse ektpaprlaa ektkkeeymk
     1561 klhmqerave evklaikpfy qkrevtkeey kdilrkavqk ichsksgein pvkvanlvka
     1621 yvdkyrhmrr hkkpeageep ptqgaeg
//
LOCUS       XP_054225468            1646 aa            linear   PRI 05-AUG-2025
DEFINITION  PHD and RING finger domain-containing protein 1 isoform X3 [Homo
            sapiens].
ACCESSION   XP_054225468
VERSION     XP_054225468.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369493.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1646
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1646
                     /product="PHD and RING finger domain-containing protein 1
                     isoform X3"
                     /calculated_mol_wt=178188
     Region          <46..103
                     /region_name="DNA_pol_phi"
                     /note="DNA polymerase phi; pfam04931"
                     /db_xref="CDD:461488"
     Region          99..149
                     /region_name="mRING-HC-C3HC3D_PHRF1"
                     /note="Modified RING finger, HC subclass (C3HC3D-type),
                     found in PHD and RING finger domain-containing protein 1
                     (PHRF1) and similar proteins; cd16635"
                     /db_xref="CDD:438297"
     Region          182..227
                     /region_name="PHD_PHRF1"
                     /note="PHD finger found in PHD and RING finger
                     domain-containing protein 1 (PHRF1); cd15536"
                     /db_xref="CDD:277011"
     Site            order(182,194..198,202,222)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277011"
     Region          <1286..1552
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..1646
                     /gene="PHRF1"
                     /gene_synonym="PPP1R125; RNF221"
                     /coded_by="XM_054369493.1:145..5085"
                     /db_xref="GeneID:57661"
                     /db_xref="HGNC:HGNC:24351"
                     /db_xref="MIM:611780"
ORIGIN      
        1 mdddsldelv arspgpdghp qvgpadpaee ssvgssgdsg ddsdsehgdg tdgedegase
       61 eedledrsgs edseddgetl levagtqgkl eaagsfnsdd daescpicln afrdqavgtp
      121 encahyfcld civewsknan scpvdrtlfk ciciraqfgg kilrkipven tkaseeeedp
      181 tfcevcgrsd redrlllcdg cdagyhmecl dpplqevpvd ewfcpecaap gvvlaadagp
      241 vseeevslll advvpttsrl rpragrtrai artrqservr atvnrnrist arrvqhtpgr
      301 lgsslldeai eavatglsta vyqrpltprt parrkrktrr rkkvpgrkkt psgpsaksks
      361 satrskkrqh rvkkrrgkkv kseattrsri artlglrrpv hsscipsvlk pvepslgllr
      421 adigaaslsl fgdpyeldpf dsseelsanp lsplsakrra lsrsalqshq pvarpvsvgl
      481 srrrlpaavp epdleeepvp dllgsilsgq sllmlgssdv iihrdgslsa kraapvsfqr
      541 nsgslsrgee gfkgclqpra lpsgspaqgp sgnrpqstgl scqgrsrtpa rtagapvrld
      601 lpaapgavqa rnlsngsvpg frqshspwfn gtnkhtlpla saaskissrd skppcrsvvp
      661 gpplkpaprr tdiselprip kirrddgggr rdaapahgqs ieipsacisr ltgregtgqp
      721 grgtraesea ssrvprepgv htgssrppap sshgslaplg psrgkgvgst fesfrinipg
      781 nmahssqlss pgfcntfrpv ddkeqrkenp splfsikktk qlrsevydps dptgsdssap
      841 gsspersgpg llpseitrti sinspkaqtv qavrcvtsyt vesifgtepe pplgpssams
      901 klrgavaaeg asdtereept esqglaarlr rpsppepwde edgascstff gseertvtcv
      961 tvvepeapps pdvlqaathr vvelrppsrs rstsssrsrk kakrkrvsre hgrtrsgtrs
     1021 esrdrssrsa spsvgeerpr rqrskaksrr sssdrsssre rakrkkakdk srehrrgpwg
     1081 hsrrtsrsrs gspgsssyeh yesrkkkkrr sasrprgrec sptsslerlc rhkhqrersh
     1141 erpdrkesva wprdrrkrrs rspssehrar ehrrprsrek wpqtrshspe rkgavreasp
     1201 aplaqgepgr edlptrlpal geahvspeva tadkaplqap pvlevaaece pddldldygd
     1261 sveaghvfdd fssdavfiql ddmssppspe stdssperdf plkpalppas lavaaiqrev
     1321 slmhdedpsq ppplpegtqe phllrpdaae kaeapsspdv apagkedsps asgrvqeaar
     1381 peevvsqtpl lrsralvkrv twnlqesess apaedrapra plhrpqkpre gawdmedvap
     1441 tgvrqafsel pfpshvlpep gfpdtdpsqv yspglppapa qpssippcal vsqptvqfil
     1501 qgslplvgcg aaqtlapvpa altpasepas qataasnsee ktpaprlaae ktkkeeymkk
     1561 lhmqeravee vklaikpfyq krevtkeeyk dilrkavqki chsksgeinp vkvanlvkay
     1621 vdkyrhmrrh kkpeageepp tqgaeg
//
LOCUS       XP_054225469            1646 aa            linear   PRI 05-AUG-2025
DEFINITION  PHD and RING finger domain-containing protein 1 isoform X4 [Homo
            sapiens].
ACCESSION   XP_054225469
VERSION     XP_054225469.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369494.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1646
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1646
                     /product="PHD and RING finger domain-containing protein 1
                     isoform X4"
                     /calculated_mol_wt=178151
     Region          <48..105
                     /region_name="DNA_pol_phi"
                     /note="DNA polymerase phi; pfam04931"
                     /db_xref="CDD:461488"
     Region          101..151
                     /region_name="mRING-HC-C3HC3D_PHRF1"
                     /note="Modified RING finger, HC subclass (C3HC3D-type),
                     found in PHD and RING finger domain-containing protein 1
                     (PHRF1) and similar proteins; cd16635"
                     /db_xref="CDD:438297"
     Region          184..229
                     /region_name="PHD_PHRF1"
                     /note="PHD finger found in PHD and RING finger
                     domain-containing protein 1 (PHRF1); cd15536"
                     /db_xref="CDD:277011"
     Site            order(184,196..200,204,224)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277011"
     Region          <1286..1552
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..1646
                     /gene="PHRF1"
                     /gene_synonym="PPP1R125; RNF221"
                     /coded_by="XM_054369494.1:145..5085"
                     /db_xref="GeneID:57661"
                     /db_xref="HGNC:HGNC:24351"
                     /db_xref="MIM:611780"
ORIGIN      
        1 mdddsldelv arspgpdghp qvgpadpagd fessvgssgd sgddsdsehg dgtdgedega
       61 seeedledrs gsedseddge tllevagtqg kleaagsfns dddaescpic lnafrdqavg
      121 tpencahyfc ldcivewskn anscpvdrtl fkciciraqf ggkilrkipv entkaseeee
      181 dptfcevcgr sdredrlllc dgcdagyhme cldpplqevp vdewfcpeca apgvvlaada
      241 gpvseeevsl lladvvptts rlrpragrtr aiartrqser vratvnrnri starrvqhtp
      301 grlgssllde aieavatgls tavyqrpltp rtparrkrkt rrrkkvpgrk ktpsgpsaks
      361 kssatrskkr qhrvkkrrgk kseattrsri artlglrrpv hsscipsvlk pvepslgllr
      421 adigaaslsl fgdpyeldpf dsseelsanp lsplsakrra lsrsalqshq pvarpvsvgl
      481 srrrlpaavp epdleeepvp dllgsilsgq sllmlgssdv iihrdgslsa kraapvsfqr
      541 nsgslsrgee gfkgclqpra lpsgspaqgp sgnrpqstgl scqgrsrtpa rtagapvrld
      601 lpaapgavqa rnlsngsvpg frqshspwfn gtnkhtlpla saaskissrd skppcrsvvp
      661 gpplkpaprr tdiselprip kirrddgggr rdaapahgqs ieipsacisr ltgregtgqp
      721 grgtraesea ssrvprepgv htgssrppap sshgslaplg psrgkgvgst fesfrinipg
      781 nmahssqlss pgfcntfrpv ddkeqrkenp splfsikktk qlrsevydps dptgsdssap
      841 gsspersgpg llpseitrti sinspkaqtv qavrcvtsyt vesifgtepe pplgpssams
      901 klrgavaaeg asdtereept esqglaarlr rpsppepwde edgascstff gseertvtcv
      961 tvvepeapps pdvlqaathr vvelrppsrs rstsssrsrk kakrkrvsre hgrtrsgtrs
     1021 esrdrssrsa spsvgeerpr rqrskaksrr sssdrsssre rakrkkakdk srehrrgpwg
     1081 hsrrtsrsrs gspgsssyeh yesrkkkkrr sasrprgrec sptsslerlc rhkhqrersh
     1141 erpdrkesva wprdrrkrrs rspssehrar ehrrprsrek wpqtrshspe rkgavreasp
     1201 aplaqgepgr edlptrlpal geahvspeva tadkaplqap pvlevaaece pddldldygd
     1261 sveaghvfdd fssdavfiql ddmssppspe stdssperdf plkpalppas lavaaiqrev
     1321 slmhdedpsq ppplpegtqe phllrpdaae kaeapsspdv apagkedsps asgrvqeaar
     1381 peevvsqtpl lrsralvkrv twnlqesess apaedrapra plhrpqkpre gawdmedvap
     1441 tgvrqafsel pfpshvlpep gfpdtdpsqv yspglppapa qpssippcal vsqptvqfil
     1501 qgslplvgcg aaqtlapvpa altpasepas qataasnsee ktpaprlaae ktkkeeymkk
     1561 lhmqeravee vklaikpfyq krevtkeeyk dilrkavqki chsksgeinp vkvanlvkay
     1621 vdkyrhmrrh kkpeageepp tqgaeg
//
LOCUS       XP_054225470            1646 aa            linear   PRI 05-AUG-2025
DEFINITION  PHD and RING finger domain-containing protein 1 isoform X5 [Homo
            sapiens].
ACCESSION   XP_054225470
VERSION     XP_054225470.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369495.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1646
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1646
                     /product="PHD and RING finger domain-containing protein 1
                     isoform X5"
                     /calculated_mol_wt=178193
     Region          <49..106
                     /region_name="DNA_pol_phi"
                     /note="DNA polymerase phi; pfam04931"
                     /db_xref="CDD:461488"
     Region          102..152
                     /region_name="mRING-HC-C3HC3D_PHRF1"
                     /note="Modified RING finger, HC subclass (C3HC3D-type),
                     found in PHD and RING finger domain-containing protein 1
                     (PHRF1) and similar proteins; cd16635"
                     /db_xref="CDD:438297"
     Region          185..230
                     /region_name="PHD_PHRF1"
                     /note="PHD finger found in PHD and RING finger
                     domain-containing protein 1 (PHRF1); cd15536"
                     /db_xref="CDD:277011"
     Site            order(185,197..201,205,225)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277011"
     Region          <1286..1552
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..1646
                     /gene="PHRF1"
                     /gene_synonym="PPP1R125; RNF221"
                     /coded_by="XM_054369495.1:145..5085"
                     /db_xref="GeneID:57661"
                     /db_xref="HGNC:HGNC:24351"
                     /db_xref="MIM:611780"
ORIGIN      
        1 mdddsldelv arspgpdghp qvgpadpagd feessvgssg dsgddsdseh gdgtdgedeg
       61 aseeedledr sgsedseddg etllevagtq gkleaagsfn sdddaescpi clnafrdqav
      121 gtpencahyf cldcivewsk nanscpvdrt lfkciciraq fggkilrkip ventkaseee
      181 edptfcevcg rsdredrlll cdgcdagyhm ecldpplqev pvdewfcpec aapgvvlaad
      241 agpvseeevs llladvvptt srlrpragrt raiartrqse rvratvnrnr istarrvqht
      301 pgrlgsslld eaieavatgl stavyqrplt prtparrkrk trrrkkvpgr kktpsgpsak
      361 skssatrskk rqhrvkkrrg kkseattrsr iartlglrrp vhsscipsvl kpvepslgll
      421 radigaasls lfgdpyeldp fdseelsanp lsplsakrra lsrsalqshq pvarpvsvgl
      481 srrrlpaavp epdleeepvp dllgsilsgq sllmlgssdv iihrdgslsa kraapvsfqr
      541 nsgslsrgee gfkgclqpra lpsgspaqgp sgnrpqstgl scqgrsrtpa rtagapvrld
      601 lpaapgavqa rnlsngsvpg frqshspwfn gtnkhtlpla saaskissrd skppcrsvvp
      661 gpplkpaprr tdiselprip kirrddgggr rdaapahgqs ieipsacisr ltgregtgqp
      721 grgtraesea ssrvprepgv htgssrppap sshgslaplg psrgkgvgst fesfrinipg
      781 nmahssqlss pgfcntfrpv ddkeqrkenp splfsikktk qlrsevydps dptgsdssap
      841 gsspersgpg llpseitrti sinspkaqtv qavrcvtsyt vesifgtepe pplgpssams
      901 klrgavaaeg asdtereept esqglaarlr rpsppepwde edgascstff gseertvtcv
      961 tvvepeapps pdvlqaathr vvelrppsrs rstsssrsrk kakrkrvsre hgrtrsgtrs
     1021 esrdrssrsa spsvgeerpr rqrskaksrr sssdrsssre rakrkkakdk srehrrgpwg
     1081 hsrrtsrsrs gspgsssyeh yesrkkkkrr sasrprgrec sptsslerlc rhkhqrersh
     1141 erpdrkesva wprdrrkrrs rspssehrar ehrrprsrek wpqtrshspe rkgavreasp
     1201 aplaqgepgr edlptrlpal geahvspeva tadkaplqap pvlevaaece pddldldygd
     1261 sveaghvfdd fssdavfiql ddmssppspe stdssperdf plkpalppas lavaaiqrev
     1321 slmhdedpsq ppplpegtqe phllrpdaae kaeapsspdv apagkedsps asgrvqeaar
     1381 peevvsqtpl lrsralvkrv twnlqesess apaedrapra plhrpqkpre gawdmedvap
     1441 tgvrqafsel pfpshvlpep gfpdtdpsqv yspglppapa qpssippcal vsqptvqfil
     1501 qgslplvgcg aaqtlapvpa altpasepas qataasnsee ktpaprlaae ktkkeeymkk
     1561 lhmqeravee vklaikpfyq krevtkeeyk dilrkavqki chsksgeinp vkvanlvkay
     1621 vdkyrhmrrh kkpeageepp tqgaeg
//
LOCUS       XP_054225471            1645 aa            linear   PRI 05-AUG-2025
DEFINITION  PHD and RING finger domain-containing protein 1 isoform X6 [Homo
            sapiens].
ACCESSION   XP_054225471
VERSION     XP_054225471.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369496.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1645
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1645
                     /product="PHD and RING finger domain-containing protein 1
                     isoform X6"
                     /calculated_mol_wt=178101
     Region          <46..103
                     /region_name="DNA_pol_phi"
                     /note="DNA polymerase phi; pfam04931"
                     /db_xref="CDD:461488"
     Region          99..149
                     /region_name="mRING-HC-C3HC3D_PHRF1"
                     /note="Modified RING finger, HC subclass (C3HC3D-type),
                     found in PHD and RING finger domain-containing protein 1
                     (PHRF1) and similar proteins; cd16635"
                     /db_xref="CDD:438297"
     Region          182..227
                     /region_name="PHD_PHRF1"
                     /note="PHD finger found in PHD and RING finger
                     domain-containing protein 1 (PHRF1); cd15536"
                     /db_xref="CDD:277011"
     Site            order(182,194..198,202,222)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277011"
     Region          <1285..1551
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..1645
                     /gene="PHRF1"
                     /gene_synonym="PPP1R125; RNF221"
                     /coded_by="XM_054369496.1:145..5082"
                     /db_xref="GeneID:57661"
                     /db_xref="HGNC:HGNC:24351"
                     /db_xref="MIM:611780"
ORIGIN      
        1 mdddsldelv arspgpdghp qvgpadpaee ssvgssgdsg ddsdsehgdg tdgedegase
       61 eedledrsgs edseddgetl levagtqgkl eaagsfnsdd daescpicln afrdqavgtp
      121 encahyfcld civewsknan scpvdrtlfk ciciraqfgg kilrkipven tkaseeeedp
      181 tfcevcgrsd redrlllcdg cdagyhmecl dpplqevpvd ewfcpecaap gvvlaadagp
      241 vseeevslll advvpttsrl rpragrtrai artrqservr atvnrnrist arrvqhtpgr
      301 lgsslldeai eavatglsta vyqrpltprt parrkrktrr rkkvpgrkkt psgpsaksks
      361 satrskkrqh rvkkrrgkkv kseattrsri artlglrrpv hsscipsvlk pvepslgllr
      421 adigaaslsl fgdpyeldpf dseelsanpl splsakrral srsalqshqp varpvsvgls
      481 rrrlpaavpe pdleeepvpd llgsilsgqs llmlgssdvi ihrdgslsak raapvsfqrn
      541 sgslsrgeeg fkgclqpral psgspaqgps gnrpqstgls cqgrsrtpar tagapvrldl
      601 paapgavqar nlsngsvpgf rqshspwfng tnkhtlplas aaskissrds kppcrsvvpg
      661 pplkpaprrt diselpripk irrddgggrr daapahgqsi eipsacisrl tgregtgqpg
      721 rgtraeseas srvprepgvh tgssrppaps shgslaplgp srgkgvgstf esfrinipgn
      781 mahssqlssp gfcntfrpvd dkeqrkenps plfsikktkq lrsevydpsd ptgsdssapg
      841 sspersgpgl lpseitrtis inspkaqtvq avrcvtsytv esifgtepep plgpssamsk
      901 lrgavaaega sdtereepte sqglaarlrr psppepwdee dgascstffg seertvtcvt
      961 vvepeappsp dvlqaathrv velrppsrsr stsssrsrkk akrkrvsreh grtrsgtrse
     1021 srdrssrsas psvgeerprr qrskaksrrs ssdrsssrer akrkkakdks rehrrgpwgh
     1081 srrtsrsrsg spgsssyehy esrkkkkrrs asrprgrecs ptsslerlcr hkhqrershe
     1141 rpdrkesvaw prdrrkrrsr spssehrare hrrprsrekw pqtrshsper kgavreaspa
     1201 plaqgepgre dlptrlpalg eahvspevat adkaplqapp vlevaaecep ddldldygds
     1261 veaghvfddf ssdavfiqld dmssppspes tdssperdfp lkpalppasl avaaiqrevs
     1321 lmhdedpsqp pplpegtqep hllrpdaaek aeapsspdva pagkedspsa sgrvqeaarp
     1381 eevvsqtpll rsralvkrvt wnlqesessa paedraprap lhrpqkpreg awdmedvapt
     1441 gvrqafselp fpshvlpepg fpdtdpsqvy spglppapaq pssippcalv sqptvqfilq
     1501 gslplvgcga aqtlapvpaa ltpasepasq ataasnseek tpaprlaaek tkkeeymkkl
     1561 hmqeraveev klaikpfyqk revtkeeykd ilrkavqkic hsksgeinpv kvanlvkayv
     1621 dkyrhmrrhk kpeageeppt qgaeg
//
LOCUS       XP_054225472            1645 aa            linear   PRI 05-AUG-2025
DEFINITION  PHD and RING finger domain-containing protein 1 isoform X17 [Homo
            sapiens].
ACCESSION   XP_054225472
VERSION     XP_054225472.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369497.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1645
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1645
                     /product="PHD and RING finger domain-containing protein 1
                     isoform X17"
                     /calculated_mol_wt=178064
     Region          <48..105
                     /region_name="DNA_pol_phi"
                     /note="DNA polymerase phi; pfam04931"
                     /db_xref="CDD:461488"
     Region          101..151
                     /region_name="mRING-HC-C3HC3D_PHRF1"
                     /note="Modified RING finger, HC subclass (C3HC3D-type),
                     found in PHD and RING finger domain-containing protein 1
                     (PHRF1) and similar proteins; cd16635"
                     /db_xref="CDD:438297"
     Region          184..229
                     /region_name="PHD_PHRF1"
                     /note="PHD finger found in PHD and RING finger
                     domain-containing protein 1 (PHRF1); cd15536"
                     /db_xref="CDD:277011"
     Site            order(184,196..200,204,224)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277011"
     Region          <1285..1551
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..1645
                     /gene="PHRF1"
                     /gene_synonym="PPP1R125; RNF221"
                     /coded_by="XM_054369497.1:145..5082"
                     /db_xref="GeneID:57661"
                     /db_xref="HGNC:HGNC:24351"
                     /db_xref="MIM:611780"
ORIGIN      
        1 mdddsldelv arspgpdghp qvgpadpagd fessvgssgd sgddsdsehg dgtdgedega
       61 seeedledrs gsedseddge tllevagtqg kleaagsfns dddaescpic lnafrdqavg
      121 tpencahyfc ldcivewskn anscpvdrtl fkciciraqf ggkilrkipv entkaseeee
      181 dptfcevcgr sdredrlllc dgcdagyhme cldpplqevp vdewfcpeca apgvvlaada
      241 gpvseeevsl lladvvptts rlrpragrtr aiartrqser vratvnrnri starrvqhtp
      301 grlgssllde aieavatgls tavyqrpltp rtparrkrkt rrrkkvpgrk ktpsgpsaks
      361 kssatrskkr qhrvkkrrgk kseattrsri artlglrrpv hsscipsvlk pvepslgllr
      421 adigaaslsl fgdpyeldpf dseelsanpl splsakrral srsalqshqp varpvsvgls
      481 rrrlpaavpe pdleeepvpd llgsilsgqs llmlgssdvi ihrdgslsak raapvsfqrn
      541 sgslsrgeeg fkgclqpral psgspaqgps gnrpqstgls cqgrsrtpar tagapvrldl
      601 paapgavqar nlsngsvpgf rqshspwfng tnkhtlplas aaskissrds kppcrsvvpg
      661 pplkpaprrt diselpripk irrddgggrr daapahgqsi eipsacisrl tgregtgqpg
      721 rgtraeseas srvprepgvh tgssrppaps shgslaplgp srgkgvgstf esfrinipgn
      781 mahssqlssp gfcntfrpvd dkeqrkenps plfsikktkq lrsevydpsd ptgsdssapg
      841 sspersgpgl lpseitrtis inspkaqtvq avrcvtsytv esifgtepep plgpssamsk
      901 lrgavaaega sdtereepte sqglaarlrr psppepwdee dgascstffg seertvtcvt
      961 vvepeappsp dvlqaathrv velrppsrsr stsssrsrkk akrkrvsreh grtrsgtrse
     1021 srdrssrsas psvgeerprr qrskaksrrs ssdrsssrer akrkkakdks rehrrgpwgh
     1081 srrtsrsrsg spgsssyehy esrkkkkrrs asrprgrecs ptsslerlcr hkhqrershe
     1141 rpdrkesvaw prdrrkrrsr spssehrare hrrprsrekw pqtrshsper kgavreaspa
     1201 plaqgepgre dlptrlpalg eahvspevat adkaplqapp vlevaaecep ddldldygds
     1261 veaghvfddf ssdavfiqld dmssppspes tdssperdfp lkpalppasl avaaiqrevs
     1321 lmhdedpsqp pplpegtqep hllrpdaaek aeapsspdva pagkedspsa sgrvqeaarp
     1381 eevvsqtpll rsralvkrvt wnlqesessa paedraprap lhrpqkpreg awdmedvapt
     1441 gvrqafselp fpshvlpepg fpdtdpsqvy spglppapaq pssippcalv sqptvqfilq
     1501 gslplvgcga aqtlapvpaa ltpasepasq ataasnseek tpaprlaaek tkkeeymkkl
     1561 hmqeraveev klaikpfyqk revtkeeykd ilrkavqkic hsksgeinpv kvanlvkayv
     1621 dkyrhmrrhk kpeageeppt qgaeg
//
LOCUS       XP_054225473            1644 aa            linear   PRI 05-AUG-2025
DEFINITION  PHD and RING finger domain-containing protein 1 isoform X7 [Homo
            sapiens].
ACCESSION   XP_054225473
VERSION     XP_054225473.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369498.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1644
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1644
                     /product="PHD and RING finger domain-containing protein 1
                     isoform X7"
                     /calculated_mol_wt=177961
     Region          <46..103
                     /region_name="DNA_pol_phi"
                     /note="DNA polymerase phi; pfam04931"
                     /db_xref="CDD:461488"
     Region          99..149
                     /region_name="mRING-HC-C3HC3D_PHRF1"
                     /note="Modified RING finger, HC subclass (C3HC3D-type),
                     found in PHD and RING finger domain-containing protein 1
                     (PHRF1) and similar proteins; cd16635"
                     /db_xref="CDD:438297"
     Region          182..227
                     /region_name="PHD_PHRF1"
                     /note="PHD finger found in PHD and RING finger
                     domain-containing protein 1 (PHRF1); cd15536"
                     /db_xref="CDD:277011"
     Site            order(182,194..198,202,222)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277011"
     Region          <1284..1550
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..1644
                     /gene="PHRF1"
                     /gene_synonym="PPP1R125; RNF221"
                     /coded_by="XM_054369498.1:145..5079"
                     /db_xref="GeneID:57661"
                     /db_xref="HGNC:HGNC:24351"
                     /db_xref="MIM:611780"
ORIGIN      
        1 mdddsldelv arspgpdghp qvgpadpaee ssvgssgdsg ddsdsehgdg tdgedegase
       61 eedledrsgs edseddgetl levagtqgkl eaagsfnsdd daescpicln afrdqavgtp
      121 encahyfcld civewsknan scpvdrtlfk ciciraqfgg kilrkipven tkaseeeedp
      181 tfcevcgrsd redrlllcdg cdagyhmecl dpplqevpvd ewfcpecaap gvvlaadagp
      241 vseeevslll advvpttsrl rpragrtrai artrqservr atvnrnrist arrvqhtpgr
      301 lgsslldeai eavatglsta vyqrpltprt parrkrktrr rkkvpgrkkt psgpsaksks
      361 satrskkrqh rvkkrrgkks eattrsriar tlglrrpvhs scipsvlkpv epslgllrad
      421 igaaslslfg dpyeldpfds seelsanpls plsakrrals rsalqshqpv arpvsvglsr
      481 rrlpaavpep dleeepvpdl lgsilsgqsl lmlgssdvii hrdgslsakr aapvsfqrns
      541 gslsrgeegf kgclqpralp sgspaqgpsg nrpqstglsc qgrsrtpart agapvrldlp
      601 aapgavqarn lsngsvpgfr qshspwfngt nkhtlplasa askissrdsk ppcrsvvpgp
      661 plkpaprrtd iselpripki rrddgggrrd aapahgqsie ipsacisrlt gregtgqpgr
      721 gtraeseass rvprepgvht gssrppapss hgslaplgps rgkgvgstfe sfrinipgnm
      781 ahssqlsspg fcntfrpvdd keqrkenpsp lfsikktkql rsevydpsdp tgsdssapgs
      841 spersgpgll pseitrtisi nspkaqtvqa vrcvtsytve sifgtepepp lgpssamskl
      901 rgavaaegas dtereeptes qglaarlrrp sppepwdeed gascstffgs eertvtcvtv
      961 vepeappspd vlqaathrvv elrppsrsrs tsssrsrkka krkrvsrehg rtrsgtrses
     1021 rdrssrsasp svgeerprrq rskaksrrss sdrsssrera krkkakdksr ehrrgpwghs
     1081 rrtsrsrsgs pgsssyehye srkkkkrrsa srprgrecsp tsslerlcrh khqrersher
     1141 pdrkesvawp rdrrkrrsrs pssehrareh rrprsrekwp qtrshsperk gavreaspap
     1201 laqgepgred lptrlpalge ahvspevata dkaplqappv levaaecepd dldldygdsv
     1261 eaghvfddfs sdavfiqldd mssppspest dssperdfpl kpalppasla vaaiqrevsl
     1321 mhdedpsqpp plpegtqeph llrpdaaeka eapsspdvap agkedspsas grvqeaarpe
     1381 evvsqtpllr sralvkrvtw nlqesessap aedraprapl hrpqkprega wdmedvaptg
     1441 vrqafselpf pshvlpepgf pdtdpsqvys pglppapaqp ssippcalvs qptvqfilqg
     1501 slplvgcgaa qtlapvpaal tpasepasqa taasnseekt paprlaaekt kkeeymkklh
     1561 mqeraveevk laikpfyqkr evtkeeykdi lrkavqkich sksgeinpvk vanlvkayvd
     1621 kyrhmrrhkk peageepptq gaeg
//
LOCUS       XP_054225474            1644 aa            linear   PRI 05-AUG-2025
DEFINITION  PHD and RING finger domain-containing protein 1 isoform X18 [Homo
            sapiens].
ACCESSION   XP_054225474
VERSION     XP_054225474.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369499.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1644
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1644
                     /product="PHD and RING finger domain-containing protein 1
                     isoform X18"
                     /calculated_mol_wt=177972
     Region          <45..102
                     /region_name="DNA_pol_phi"
                     /note="DNA polymerase phi; pfam04931"
                     /db_xref="CDD:461488"
     Region          98..148
                     /region_name="mRING-HC-C3HC3D_PHRF1"
                     /note="Modified RING finger, HC subclass (C3HC3D-type),
                     found in PHD and RING finger domain-containing protein 1
                     (PHRF1) and similar proteins; cd16635"
                     /db_xref="CDD:438297"
     Region          181..226
                     /region_name="PHD_PHRF1"
                     /note="PHD finger found in PHD and RING finger
                     domain-containing protein 1 (PHRF1); cd15536"
                     /db_xref="CDD:277011"
     Site            order(181,193..197,201,221)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277011"
     Region          <1284..1550
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..1644
                     /gene="PHRF1"
                     /gene_synonym="PPP1R125; RNF221"
                     /coded_by="XM_054369499.1:145..5079"
                     /db_xref="GeneID:57661"
                     /db_xref="HGNC:HGNC:24351"
                     /db_xref="MIM:611780"
ORIGIN      
        1 mdddsldelv arspgpdghp qvgpadpaes svgssgdsgd dsdsehgdgt dgedegasee
       61 edledrsgse dseddgetll evagtqgkle aagsfnsddd aescpiclna frdqavgtpe
      121 ncahyfcldc ivewsknans cpvdrtlfkc iciraqfggk ilrkipvent kaseeeedpt
      181 fcevcgrsdr edrlllcdgc dagyhmecld pplqevpvde wfcpecaapg vvlaadagpv
      241 seeevsllla dvvpttsrlr pragrtraia rtrqservra tvnrnrista rrvqhtpgrl
      301 gsslldeaie avatglstav yqrpltprtp arrkrktrrr kkvpgrkktp sgpsakskss
      361 atrskkrqhr vkkrrgkkvk seattrsria rtlglrrpvh sscipsvlkp vepslgllra
      421 digaaslslf gdpyeldpfd seelsanpls plsakrrals rsalqshqpv arpvsvglsr
      481 rrlpaavpep dleeepvpdl lgsilsgqsl lmlgssdvii hrdgslsakr aapvsfqrns
      541 gslsrgeegf kgclqpralp sgspaqgpsg nrpqstglsc qgrsrtpart agapvrldlp
      601 aapgavqarn lsngsvpgfr qshspwfngt nkhtlplasa askissrdsk ppcrsvvpgp
      661 plkpaprrtd iselpripki rrddgggrrd aapahgqsie ipsacisrlt gregtgqpgr
      721 gtraeseass rvprepgvht gssrppapss hgslaplgps rgkgvgstfe sfrinipgnm
      781 ahssqlsspg fcntfrpvdd keqrkenpsp lfsikktkql rsevydpsdp tgsdssapgs
      841 spersgpgll pseitrtisi nspkaqtvqa vrcvtsytve sifgtepepp lgpssamskl
      901 rgavaaegas dtereeptes qglaarlrrp sppepwdeed gascstffgs eertvtcvtv
      961 vepeappspd vlqaathrvv elrppsrsrs tsssrsrkka krkrvsrehg rtrsgtrses
     1021 rdrssrsasp svgeerprrq rskaksrrss sdrsssrera krkkakdksr ehrrgpwghs
     1081 rrtsrsrsgs pgsssyehye srkkkkrrsa srprgrecsp tsslerlcrh khqrersher
     1141 pdrkesvawp rdrrkrrsrs pssehrareh rrprsrekwp qtrshsperk gavreaspap
     1201 laqgepgred lptrlpalge ahvspevata dkaplqappv levaaecepd dldldygdsv
     1261 eaghvfddfs sdavfiqldd mssppspest dssperdfpl kpalppasla vaaiqrevsl
     1321 mhdedpsqpp plpegtqeph llrpdaaeka eapsspdvap agkedspsas grvqeaarpe
     1381 evvsqtpllr sralvkrvtw nlqesessap aedraprapl hrpqkprega wdmedvaptg
     1441 vrqafselpf pshvlpepgf pdtdpsqvys pglppapaqp ssippcalvs qptvqfilqg
     1501 slplvgcgaa qtlapvpaal tpasepasqa taasnseekt paprlaaekt kkeeymkklh
     1561 mqeraveevk laikpfyqkr evtkeeykdi lrkavqkich sksgeinpvk vanlvkayvd
     1621 kyrhmrrhkk peageepptq gaeg
//
LOCUS       XP_054225475            1643 aa            linear   PRI 05-AUG-2025
DEFINITION  PHD and RING finger domain-containing protein 1 isoform X8 [Homo
            sapiens].
ACCESSION   XP_054225475
VERSION     XP_054225475.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369500.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1643
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1643
                     /product="PHD and RING finger domain-containing protein 1
                     isoform X8"
                     /calculated_mol_wt=177832
     Region          <45..102
                     /region_name="DNA_pol_phi"
                     /note="DNA polymerase phi; pfam04931"
                     /db_xref="CDD:461488"
     Region          98..148
                     /region_name="mRING-HC-C3HC3D_PHRF1"
                     /note="Modified RING finger, HC subclass (C3HC3D-type),
                     found in PHD and RING finger domain-containing protein 1
                     (PHRF1) and similar proteins; cd16635"
                     /db_xref="CDD:438297"
     Region          181..226
                     /region_name="PHD_PHRF1"
                     /note="PHD finger found in PHD and RING finger
                     domain-containing protein 1 (PHRF1); cd15536"
                     /db_xref="CDD:277011"
     Site            order(181,193..197,201,221)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277011"
     Region          <1283..1549
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..1643
                     /gene="PHRF1"
                     /gene_synonym="PPP1R125; RNF221"
                     /coded_by="XM_054369500.1:145..5076"
                     /db_xref="GeneID:57661"
                     /db_xref="HGNC:HGNC:24351"
                     /db_xref="MIM:611780"
ORIGIN      
        1 mdddsldelv arspgpdghp qvgpadpaes svgssgdsgd dsdsehgdgt dgedegasee
       61 edledrsgse dseddgetll evagtqgkle aagsfnsddd aescpiclna frdqavgtpe
      121 ncahyfcldc ivewsknans cpvdrtlfkc iciraqfggk ilrkipvent kaseeeedpt
      181 fcevcgrsdr edrlllcdgc dagyhmecld pplqevpvde wfcpecaapg vvlaadagpv
      241 seeevsllla dvvpttsrlr pragrtraia rtrqservra tvnrnrista rrvqhtpgrl
      301 gsslldeaie avatglstav yqrpltprtp arrkrktrrr kkvpgrkktp sgpsakskss
      361 atrskkrqhr vkkrrgkkse attrsriart lglrrpvhss cipsvlkpve pslgllradi
      421 gaaslslfgd pyeldpfdss eelsanplsp lsakrralsr salqshqpva rpvsvglsrr
      481 rlpaavpepd leeepvpdll gsilsgqsll mlgssdviih rdgslsakra apvsfqrnsg
      541 slsrgeegfk gclqpralps gspaqgpsgn rpqstglscq grsrtparta gapvrldlpa
      601 apgavqarnl sngsvpgfrq shspwfngtn khtlplasaa skissrdskp pcrsvvpgpp
      661 lkpaprrtdi selpripkir rddgggrrda apahgqsiei psacisrltg regtgqpgrg
      721 traeseassr vprepgvhtg ssrppapssh gslaplgpsr gkgvgstfes frinipgnma
      781 hssqlsspgf cntfrpvddk eqrkenpspl fsikktkqlr sevydpsdpt gsdssapgss
      841 persgpgllp seitrtisin spkaqtvqav rcvtsytves ifgtepeppl gpssamsklr
      901 gavaaegasd tereeptesq glaarlrrps ppepwdeedg ascstffgse ertvtcvtvv
      961 epeappspdv lqaathrvve lrppsrsrst sssrsrkkak rkrvsrehgr trsgtrsesr
     1021 drssrsasps vgeerprrqr skaksrrsss drsssrerak rkkakdksre hrrgpwghsr
     1081 rtsrsrsgsp gsssyehyes rkkkkrrsas rprgrecspt sslerlcrhk hqrersherp
     1141 drkesvawpr drrkrrsrsp ssehrarehr rprsrekwpq trshsperkg avreaspapl
     1201 aqgepgredl ptrlpalgea hvspevatad kaplqappvl evaaecepdd ldldygdsve
     1261 aghvfddfss davfiqlddm ssppspestd ssperdfplk palppaslav aaiqrevslm
     1321 hdedpsqppp lpegtqephl lrpdaaekae apsspdvapa gkedspsasg rvqeaarpee
     1381 vvsqtpllrs ralvkrvtwn lqesessapa edrapraplh rpqkpregaw dmedvaptgv
     1441 rqafselpfp shvlpepgfp dtdpsqvysp glppapaqps sippcalvsq ptvqfilqgs
     1501 lplvgcgaaq tlapvpaalt pasepasqat aasnseektp aprlaaektk keeymkklhm
     1561 qeraveevkl aikpfyqkre vtkeeykdil rkavqkichs ksgeinpvkv anlvkayvdk
     1621 yrhmrrhkkp eageepptqg aeg
//
LOCUS       XP_054225476            1643 aa            linear   PRI 05-AUG-2025
DEFINITION  PHD and RING finger domain-containing protein 1 isoform X19 [Homo
            sapiens].
ACCESSION   XP_054225476
VERSION     XP_054225476.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369501.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1643
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1643
                     /product="PHD and RING finger domain-containing protein 1
                     isoform X19"
                     /calculated_mol_wt=177874
     Region          <46..103
                     /region_name="DNA_pol_phi"
                     /note="DNA polymerase phi; pfam04931"
                     /db_xref="CDD:461488"
     Region          99..149
                     /region_name="mRING-HC-C3HC3D_PHRF1"
                     /note="Modified RING finger, HC subclass (C3HC3D-type),
                     found in PHD and RING finger domain-containing protein 1
                     (PHRF1) and similar proteins; cd16635"
                     /db_xref="CDD:438297"
     Region          182..227
                     /region_name="PHD_PHRF1"
                     /note="PHD finger found in PHD and RING finger
                     domain-containing protein 1 (PHRF1); cd15536"
                     /db_xref="CDD:277011"
     Site            order(182,194..198,202,222)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277011"
     Region          <1283..1549
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..1643
                     /gene="PHRF1"
                     /gene_synonym="PPP1R125; RNF221"
                     /coded_by="XM_054369501.1:145..5076"
                     /db_xref="GeneID:57661"
                     /db_xref="HGNC:HGNC:24351"
                     /db_xref="MIM:611780"
ORIGIN      
        1 mdddsldelv arspgpdghp qvgpadpaee ssvgssgdsg ddsdsehgdg tdgedegase
       61 eedledrsgs edseddgetl levagtqgkl eaagsfnsdd daescpicln afrdqavgtp
      121 encahyfcld civewsknan scpvdrtlfk ciciraqfgg kilrkipven tkaseeeedp
      181 tfcevcgrsd redrlllcdg cdagyhmecl dpplqevpvd ewfcpecaap gvvlaadagp
      241 vseeevslll advvpttsrl rpragrtrai artrqservr atvnrnrist arrvqhtpgr
      301 lgsslldeai eavatglsta vyqrpltprt parrkrktrr rkkvpgrkkt psgpsaksks
      361 satrskkrqh rvkkrrgkks eattrsriar tlglrrpvhs scipsvlkpv epslgllrad
      421 igaaslslfg dpyeldpfds eelsanplsp lsakrralsr salqshqpva rpvsvglsrr
      481 rlpaavpepd leeepvpdll gsilsgqsll mlgssdviih rdgslsakra apvsfqrnsg
      541 slsrgeegfk gclqpralps gspaqgpsgn rpqstglscq grsrtparta gapvrldlpa
      601 apgavqarnl sngsvpgfrq shspwfngtn khtlplasaa skissrdskp pcrsvvpgpp
      661 lkpaprrtdi selpripkir rddgggrrda apahgqsiei psacisrltg regtgqpgrg
      721 traeseassr vprepgvhtg ssrppapssh gslaplgpsr gkgvgstfes frinipgnma
      781 hssqlsspgf cntfrpvddk eqrkenpspl fsikktkqlr sevydpsdpt gsdssapgss
      841 persgpgllp seitrtisin spkaqtvqav rcvtsytves ifgtepeppl gpssamsklr
      901 gavaaegasd tereeptesq glaarlrrps ppepwdeedg ascstffgse ertvtcvtvv
      961 epeappspdv lqaathrvve lrppsrsrst sssrsrkkak rkrvsrehgr trsgtrsesr
     1021 drssrsasps vgeerprrqr skaksrrsss drsssrerak rkkakdksre hrrgpwghsr
     1081 rtsrsrsgsp gsssyehyes rkkkkrrsas rprgrecspt sslerlcrhk hqrersherp
     1141 drkesvawpr drrkrrsrsp ssehrarehr rprsrekwpq trshsperkg avreaspapl
     1201 aqgepgredl ptrlpalgea hvspevatad kaplqappvl evaaecepdd ldldygdsve
     1261 aghvfddfss davfiqlddm ssppspestd ssperdfplk palppaslav aaiqrevslm
     1321 hdedpsqppp lpegtqephl lrpdaaekae apsspdvapa gkedspsasg rvqeaarpee
     1381 vvsqtpllrs ralvkrvtwn lqesessapa edrapraplh rpqkpregaw dmedvaptgv
     1441 rqafselpfp shvlpepgfp dtdpsqvysp glppapaqps sippcalvsq ptvqfilqgs
     1501 lplvgcgaaq tlapvpaalt pasepasqat aasnseektp aprlaaektk keeymkklhm
     1561 qeraveevkl aikpfyqkre vtkeeykdil rkavqkichs ksgeinpvkv anlvkayvdk
     1621 yrhmrrhkkp eageepptqg aeg
//
LOCUS       XP_054225477            1642 aa            linear   PRI 05-AUG-2025
DEFINITION  PHD and RING finger domain-containing protein 1 isoform X9 [Homo
            sapiens].
ACCESSION   XP_054225477
VERSION     XP_054225477.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369502.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1642
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1642
                     /product="PHD and RING finger domain-containing protein 1
                     isoform X9"
                     /calculated_mol_wt=177745
     Region          <45..102
                     /region_name="DNA_pol_phi"
                     /note="DNA polymerase phi; pfam04931"
                     /db_xref="CDD:461488"
     Region          98..148
                     /region_name="mRING-HC-C3HC3D_PHRF1"
                     /note="Modified RING finger, HC subclass (C3HC3D-type),
                     found in PHD and RING finger domain-containing protein 1
                     (PHRF1) and similar proteins; cd16635"
                     /db_xref="CDD:438297"
     Region          181..226
                     /region_name="PHD_PHRF1"
                     /note="PHD finger found in PHD and RING finger
                     domain-containing protein 1 (PHRF1); cd15536"
                     /db_xref="CDD:277011"
     Site            order(181,193..197,201,221)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277011"
     Region          <1282..1548
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..1642
                     /gene="PHRF1"
                     /gene_synonym="PPP1R125; RNF221"
                     /coded_by="XM_054369502.1:145..5073"
                     /db_xref="GeneID:57661"
                     /db_xref="HGNC:HGNC:24351"
                     /db_xref="MIM:611780"
ORIGIN      
        1 mdddsldelv arspgpdghp qvgpadpaes svgssgdsgd dsdsehgdgt dgedegasee
       61 edledrsgse dseddgetll evagtqgkle aagsfnsddd aescpiclna frdqavgtpe
      121 ncahyfcldc ivewsknans cpvdrtlfkc iciraqfggk ilrkipvent kaseeeedpt
      181 fcevcgrsdr edrlllcdgc dagyhmecld pplqevpvde wfcpecaapg vvlaadagpv
      241 seeevsllla dvvpttsrlr pragrtraia rtrqservra tvnrnrista rrvqhtpgrl
      301 gsslldeaie avatglstav yqrpltprtp arrkrktrrr kkvpgrkktp sgpsakskss
      361 atrskkrqhr vkkrrgkkse attrsriart lglrrpvhss cipsvlkpve pslgllradi
      421 gaaslslfgd pyeldpfdse elsanplspl sakrralsrs alqshqpvar pvsvglsrrr
      481 lpaavpepdl eeepvpdllg silsgqsllm lgssdviihr dgslsakraa pvsfqrnsgs
      541 lsrgeegfkg clqpralpsg spaqgpsgnr pqstglscqg rsrtpartag apvrldlpaa
      601 pgavqarnls ngsvpgfrqs hspwfngtnk htlplasaas kissrdskpp crsvvpgppl
      661 kpaprrtdis elpripkirr ddgggrrdaa pahgqsieip sacisrltgr egtgqpgrgt
      721 raeseassrv prepgvhtgs srppapsshg slaplgpsrg kgvgstfesf rinipgnmah
      781 ssqlsspgfc ntfrpvddke qrkenpsplf sikktkqlrs evydpsdptg sdssapgssp
      841 ersgpgllps eitrtisins pkaqtvqavr cvtsytvesi fgtepepplg pssamsklrg
      901 avaaegasdt ereeptesqg laarlrrpsp pepwdeedga scstffgsee rtvtcvtvve
      961 peappspdvl qaathrvvel rppsrsrsts ssrsrkkakr krvsrehgrt rsgtrsesrd
     1021 rssrsaspsv geerprrqrs kaksrrsssd rsssrerakr kkakdksreh rrgpwghsrr
     1081 tsrsrsgspg sssyehyesr kkkkrrsasr prgrecspts slerlcrhkh qrersherpd
     1141 rkesvawprd rrkrrsrsps sehrarehrr prsrekwpqt rshsperkga vreaspapla
     1201 qgepgredlp trlpalgeah vspevatadk aplqappvle vaaecepddl dldygdsvea
     1261 ghvfddfssd avfiqlddms sppspestds sperdfplkp alppaslava aiqrevslmh
     1321 dedpsqpppl pegtqephll rpdaaekaea psspdvapag kedspsasgr vqeaarpeev
     1381 vsqtpllrsr alvkrvtwnl qesessapae drapraplhr pqkpregawd medvaptgvr
     1441 qafselpfps hvlpepgfpd tdpsqvyspg lppapaqpss ippcalvsqp tvqfilqgsl
     1501 plvgcgaaqt lapvpaaltp asepasqata asnseektpa prlaaektkk eeymkklhmq
     1561 eraveevkla ikpfyqkrev tkeeykdilr kavqkichsk sgeinpvkva nlvkayvdky
     1621 rhmrrhkkpe ageepptqga eg
//
LOCUS       XP_054225478            1609 aa            linear   PRI 05-AUG-2025
DEFINITION  PHD and RING finger domain-containing protein 1 isoform X10 [Homo
            sapiens].
ACCESSION   XP_054225478
VERSION     XP_054225478.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369503.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1609
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1609
                     /product="PHD and RING finger domain-containing protein 1
                     isoform X10"
                     /calculated_mol_wt=174449
     Region          62..112
                     /region_name="mRING-HC-C3HC3D_PHRF1"
                     /note="Modified RING finger, HC subclass (C3HC3D-type),
                     found in PHD and RING finger domain-containing protein 1
                     (PHRF1) and similar proteins; cd16635"
                     /db_xref="CDD:438297"
     Region          145..190
                     /region_name="PHD_PHRF1"
                     /note="PHD finger found in PHD and RING finger
                     domain-containing protein 1 (PHRF1); cd15536"
                     /db_xref="CDD:277011"
     Site            order(145,157..161,165,185)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277011"
     Region          <1249..1515
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..1609
                     /gene="PHRF1"
                     /gene_synonym="PPP1R125; RNF221"
                     /coded_by="XM_054369503.1:145..4974"
                     /db_xref="GeneID:57661"
                     /db_xref="HGNC:HGNC:24351"
                     /db_xref="MIM:611780"
ORIGIN      
        1 mdddsldelv arspgpdghp qvgpadpagd fgsedseddg etllevagtq gkleaagsfn
       61 sdddaescpi clnafrdqav gtpencahyf cldcivewsk nanscpvdrt lfkciciraq
      121 fggkilrkip ventkaseee edptfcevcg rsdredrlll cdgcdagyhm ecldpplqev
      181 pvdewfcpec aapgvvlaad agpvseeevs llladvvptt srlrpragrt raiartrqse
      241 rvratvnrnr istarrvqht pgrlgsslld eaieavatgl stavyqrplt prtparrkrk
      301 trrrkkvpgr kktpsgpsak skssatrskk rqhrvkkrrg kkvkseattr sriartlglr
      361 rpvhsscips vlkpvepslg llradigaas lslfgdpyel dpfdsseels anplsplsak
      421 rralsrsalq shqpvarpvs vglsrrrlpa avpepdleee pvpdllgsil sgqsllmlgs
      481 sdviihrdgs lsakraapvs fqrnsgslsr geegfkgclq pralpsgspa qgpsgnrpqs
      541 tglscqgrsr tpartagapv rldlpaapga vqarnlsngs vpgfrqshsp wfngtnkhtl
      601 plasaaskis srdskppcrs vvpgpplkpa prrtdiselp ripkirrddg ggrrdaapah
      661 gqsieipsac isrltgregt gqpgrgtrae seassrvpre pgvhtgssrp papsshgsla
      721 plgpsrgkgv gstfesfrin ipgnmahssq lsspgfcntf rpvddkeqrk enpsplfsik
      781 ktkqlrsevy dpsdptgsds sapgsspers gpgllpseit rtisinspka qtvqavrcvt
      841 sytvesifgt epepplgpss amsklrgava aegasdtere eptesqglaa rlrrpsppep
      901 wdeedgascs tffgseertv tcvtvvepea ppspdvlqaa thrvvelrpp srsrstsssr
      961 srkkakrkrv srehgrtrsg trsesrdrss rsaspsvgee rprrqrskak srrsssdrss
     1021 srerakrkka kdksrehrrg pwghsrrtsr srsgspgsss yehyesrkkk krrsasrprg
     1081 recsptssle rlcrhkhqre rsherpdrke svawprdrrk rrsrspsseh rarehrrprs
     1141 rekwpqtrsh sperkgavre aspaplaqge pgredlptrl palgeahvsp evatadkapl
     1201 qappvlevaa ecepddldld ygdsveaghv fddfssdavf iqlddmsspp spestdsspe
     1261 rdfplkpalp paslavaaiq revslmhded psqppplpeg tqephllrpd aaekaeapss
     1321 pdvapagked spsasgrvqe aarpeevvsq tpllrsralv krvtwnlqes essapaedra
     1381 praplhrpqk pregawdmed vaptgvrqaf selpfpshvl pepgfpdtdp sqvyspglpp
     1441 apaqpssipp calvsqptvq filqgslplv gcgaaqtlap vpaaltpase pasqataasn
     1501 seektpaprl aaektkkeey mkklhmqera veevklaikp fyqkrevtke eykdilrkav
     1561 qkichsksge inpvkvanlv kayvdkyrhm rrhkkpeage epptqgaeg
//
LOCUS       XP_054225479            1608 aa            linear   PRI 05-AUG-2025
DEFINITION  PHD and RING finger domain-containing protein 1 isoform X11 [Homo
            sapiens].
ACCESSION   XP_054225479
VERSION     XP_054225479.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369504.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1608
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1608
                     /product="PHD and RING finger domain-containing protein 1
                     isoform X11"
                     /calculated_mol_wt=174362
     Region          62..112
                     /region_name="mRING-HC-C3HC3D_PHRF1"
                     /note="Modified RING finger, HC subclass (C3HC3D-type),
                     found in PHD and RING finger domain-containing protein 1
                     (PHRF1) and similar proteins; cd16635"
                     /db_xref="CDD:438297"
     Region          145..190
                     /region_name="PHD_PHRF1"
                     /note="PHD finger found in PHD and RING finger
                     domain-containing protein 1 (PHRF1); cd15536"
                     /db_xref="CDD:277011"
     Site            order(145,157..161,165,185)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277011"
     Region          <1248..1514
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..1608
                     /gene="PHRF1"
                     /gene_synonym="PPP1R125; RNF221"
                     /coded_by="XM_054369504.1:145..4971"
                     /db_xref="GeneID:57661"
                     /db_xref="HGNC:HGNC:24351"
                     /db_xref="MIM:611780"
ORIGIN      
        1 mdddsldelv arspgpdghp qvgpadpagd fgsedseddg etllevagtq gkleaagsfn
       61 sdddaescpi clnafrdqav gtpencahyf cldcivewsk nanscpvdrt lfkciciraq
      121 fggkilrkip ventkaseee edptfcevcg rsdredrlll cdgcdagyhm ecldpplqev
      181 pvdewfcpec aapgvvlaad agpvseeevs llladvvptt srlrpragrt raiartrqse
      241 rvratvnrnr istarrvqht pgrlgsslld eaieavatgl stavyqrplt prtparrkrk
      301 trrrkkvpgr kktpsgpsak skssatrskk rqhrvkkrrg kkvkseattr sriartlglr
      361 rpvhsscips vlkpvepslg llradigaas lslfgdpyel dpfdseelsa nplsplsakr
      421 ralsrsalqs hqpvarpvsv glsrrrlpaa vpepdleeep vpdllgsils gqsllmlgss
      481 dviihrdgsl sakraapvsf qrnsgslsrg eegfkgclqp ralpsgspaq gpsgnrpqst
      541 glscqgrsrt partagapvr ldlpaapgav qarnlsngsv pgfrqshspw fngtnkhtlp
      601 lasaaskiss rdskppcrsv vpgpplkpap rrtdiselpr ipkirrddgg grrdaapahg
      661 qsieipsaci srltgregtg qpgrgtraes eassrvprep gvhtgssrpp apsshgslap
      721 lgpsrgkgvg stfesfrini pgnmahssql sspgfcntfr pvddkeqrke npsplfsikk
      781 tkqlrsevyd psdptgsdss apgsspersg pgllpseitr tisinspkaq tvqavrcvts
      841 ytvesifgte pepplgpssa msklrgavaa egasdteree ptesqglaar lrrpsppepw
      901 deedgascst ffgseertvt cvtvvepeap pspdvlqaat hrvvelrpps rsrstsssrs
      961 rkkakrkrvs rehgrtrsgt rsesrdrssr saspsvgeer prrqrskaks rrsssdrsss
     1021 rerakrkkak dksrehrrgp wghsrrtsrs rsgspgsssy ehyesrkkkk rrsasrprgr
     1081 ecsptssler lcrhkhqrer sherpdrkes vawprdrrkr rsrspssehr arehrrprsr
     1141 ekwpqtrshs perkgavrea spaplaqgep gredlptrlp algeahvspe vatadkaplq
     1201 appvlevaae cepddldldy gdsveaghvf ddfssdavfi qlddmsspps pestdssper
     1261 dfplkpalpp aslavaaiqr evslmhdedp sqppplpegt qephllrpda aekaeapssp
     1321 dvapagkeds psasgrvqea arpeevvsqt pllrsralvk rvtwnlqese ssapaedrap
     1381 raplhrpqkp regawdmedv aptgvrqafs elpfpshvlp epgfpdtdps qvyspglppa
     1441 paqpssippc alvsqptvqf ilqgslplvg cgaaqtlapv paaltpasep asqataasns
     1501 eektpaprla aektkkeeym kklhmqerav eevklaikpf yqkrevtkee ykdilrkavq
     1561 kichsksgei npvkvanlvk ayvdkyrhmr rhkkpeagee pptqgaeg
//
LOCUS       XP_054225480            1607 aa            linear   PRI 05-AUG-2025
DEFINITION  PHD and RING finger domain-containing protein 1 isoform X20 [Homo
            sapiens].
ACCESSION   XP_054225480
VERSION     XP_054225480.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369505.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1607
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1607
                     /product="PHD and RING finger domain-containing protein 1
                     isoform X20"
                     /calculated_mol_wt=174222
     Region          62..112
                     /region_name="mRING-HC-C3HC3D_PHRF1"
                     /note="Modified RING finger, HC subclass (C3HC3D-type),
                     found in PHD and RING finger domain-containing protein 1
                     (PHRF1) and similar proteins; cd16635"
                     /db_xref="CDD:438297"
     Region          145..190
                     /region_name="PHD_PHRF1"
                     /note="PHD finger found in PHD and RING finger
                     domain-containing protein 1 (PHRF1); cd15536"
                     /db_xref="CDD:277011"
     Site            order(145,157..161,165,185)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277011"
     Region          <1247..1513
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..1607
                     /gene="PHRF1"
                     /gene_synonym="PPP1R125; RNF221"
                     /coded_by="XM_054369505.1:145..4968"
                     /db_xref="GeneID:57661"
                     /db_xref="HGNC:HGNC:24351"
                     /db_xref="MIM:611780"
ORIGIN      
        1 mdddsldelv arspgpdghp qvgpadpagd fgsedseddg etllevagtq gkleaagsfn
       61 sdddaescpi clnafrdqav gtpencahyf cldcivewsk nanscpvdrt lfkciciraq
      121 fggkilrkip ventkaseee edptfcevcg rsdredrlll cdgcdagyhm ecldpplqev
      181 pvdewfcpec aapgvvlaad agpvseeevs llladvvptt srlrpragrt raiartrqse
      241 rvratvnrnr istarrvqht pgrlgsslld eaieavatgl stavyqrplt prtparrkrk
      301 trrrkkvpgr kktpsgpsak skssatrskk rqhrvkkrrg kkseattrsr iartlglrrp
      361 vhsscipsvl kpvepslgll radigaasls lfgdpyeldp fdsseelsan plsplsakrr
      421 alsrsalqsh qpvarpvsvg lsrrrlpaav pepdleeepv pdllgsilsg qsllmlgssd
      481 viihrdgsls akraapvsfq rnsgslsrge egfkgclqpr alpsgspaqg psgnrpqstg
      541 lscqgrsrtp artagapvrl dlpaapgavq arnlsngsvp gfrqshspwf ngtnkhtlpl
      601 asaaskissr dskppcrsvv pgpplkpapr rtdiselpri pkirrddggg rrdaapahgq
      661 sieipsacis rltgregtgq pgrgtraese assrvprepg vhtgssrppa psshgslapl
      721 gpsrgkgvgs tfesfrinip gnmahssqls spgfcntfrp vddkeqrken psplfsikkt
      781 kqlrsevydp sdptgsdssa pgsspersgp gllpseitrt isinspkaqt vqavrcvtsy
      841 tvesifgtep epplgpssam sklrgavaae gasdtereep tesqglaarl rrpsppepwd
      901 eedgascstf fgseertvtc vtvvepeapp spdvlqaath rvvelrppsr srstsssrsr
      961 kkakrkrvsr ehgrtrsgtr sesrdrssrs aspsvgeerp rrqrskaksr rsssdrsssr
     1021 erakrkkakd ksrehrrgpw ghsrrtsrsr sgspgsssye hyesrkkkkr rsasrprgre
     1081 csptsslerl crhkhqrers herpdrkesv awprdrrkrr srspssehra rehrrprsre
     1141 kwpqtrshsp erkgavreas paplaqgepg redlptrlpa lgeahvspev atadkaplqa
     1201 ppvlevaaec epddldldyg dsveaghvfd dfssdavfiq lddmssppsp estdssperd
     1261 fplkpalppa slavaaiqre vslmhdedps qppplpegtq ephllrpdaa ekaeapsspd
     1321 vapagkedsp sasgrvqeaa rpeevvsqtp llrsralvkr vtwnlqeses sapaedrapr
     1381 aplhrpqkpr egawdmedva ptgvrqafse lpfpshvlpe pgfpdtdpsq vyspglppap
     1441 aqpssippca lvsqptvqfi lqgslplvgc gaaqtlapvp aaltpasepa sqataasnse
     1501 ektpaprlaa ektkkeeymk klhmqerave evklaikpfy qkrevtkeey kdilrkavqk
     1561 ichsksgein pvkvanlvka yvdkyrhmrr hkkpeageep ptqgaeg
//
LOCUS       XP_054225481             640 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 4C isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225481
VERSION     XP_054225481.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369506.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..640
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..640
                     /product="leucine-rich repeat-containing protein 4C
                     isoform X1"
                     /calculated_mol_wt=71819
     Region          47..80
                     /region_name="LRRNT"
                     /note="Leucine rich repeat N-terminal domain; smart00013"
                     /db_xref="CDD:214470"
     Region          <76..325
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          78..101
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          102..125
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          126..149
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          150..173
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          174..198
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          199..220
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          221..244
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          245..268
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          269..290
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          360..443
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          371..375
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          383..387
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          409..413
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          423..428
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          436..439
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     CDS             1..640
                     /gene="LRRC4C"
                     /gene_synonym="NGL-1; NGL1"
                     /coded_by="XM_054369506.1:850..2772"
                     /db_xref="GeneID:57689"
                     /db_xref="HGNC:HGNC:29317"
                     /db_xref="MIM:608817"
ORIGIN      
        1 mlnkmtlhpq qimigprfnr alfdpllvvl lalqllvvag lvraqtcpsv cscsnqfskv
       61 icvrknlrev pdgistntrl lnlhenqiqi ikvnsfkhlr hleilqlsrn hirtieigaf
      121 nglanlntle lfdnrlttip ngafvylskl kelwlrnnpi esipsyafnr ipslrrldlg
      181 elkrlsyise gafeglsnlr ylnlamcnlr eipnltplik ldeldlsgnh lsairpgsfq
      241 glmhlqklwm iqsqiqvier nafdnlqslv einlahnnlt llphdlftpl hhlerihlhh
      301 npwncncdil wlswwikdma psntaccarc ntppnlkgry igeldqnyft cyapvivepp
      361 adlnvtegma aelkcrasts ltsvswitpn gtvmthgayk vriavlsdgt lnftnvtvqd
      421 tgmytcmvsn svgnttasat lnvtaatttp fsyfstvtve tmepsqdear ttdnnvgptp
      481 vvdwettnvt tsltpqstrs tektftipvt dinsgipgid evmkttkiii gcfvaitlma
      541 avmlvifykm rkqhhrqnhh aptrtveiin vddeitgdtp meshlpmpai ehehlnhyns
      601 ykspfnhttt vntinsihss vhepllirmn skdnvqetqi
//
LOCUS       XP_054225482             640 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 4C isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225482
VERSION     XP_054225482.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369507.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..640
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..640
                     /product="leucine-rich repeat-containing protein 4C
                     isoform X1"
                     /calculated_mol_wt=71819
     Region          47..80
                     /region_name="LRRNT"
                     /note="Leucine rich repeat N-terminal domain; smart00013"
                     /db_xref="CDD:214470"
     Region          <76..325
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          78..101
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          102..125
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          126..149
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          150..173
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          174..198
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          199..220
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          221..244
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          245..268
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          269..290
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          360..443
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          371..375
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          383..387
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          409..413
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          423..428
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          436..439
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     CDS             1..640
                     /gene="LRRC4C"
                     /gene_synonym="NGL-1; NGL1"
                     /coded_by="XM_054369507.1:779..2701"
                     /db_xref="GeneID:57689"
                     /db_xref="HGNC:HGNC:29317"
                     /db_xref="MIM:608817"
ORIGIN      
        1 mlnkmtlhpq qimigprfnr alfdpllvvl lalqllvvag lvraqtcpsv cscsnqfskv
       61 icvrknlrev pdgistntrl lnlhenqiqi ikvnsfkhlr hleilqlsrn hirtieigaf
      121 nglanlntle lfdnrlttip ngafvylskl kelwlrnnpi esipsyafnr ipslrrldlg
      181 elkrlsyise gafeglsnlr ylnlamcnlr eipnltplik ldeldlsgnh lsairpgsfq
      241 glmhlqklwm iqsqiqvier nafdnlqslv einlahnnlt llphdlftpl hhlerihlhh
      301 npwncncdil wlswwikdma psntaccarc ntppnlkgry igeldqnyft cyapvivepp
      361 adlnvtegma aelkcrasts ltsvswitpn gtvmthgayk vriavlsdgt lnftnvtvqd
      421 tgmytcmvsn svgnttasat lnvtaatttp fsyfstvtve tmepsqdear ttdnnvgptp
      481 vvdwettnvt tsltpqstrs tektftipvt dinsgipgid evmkttkiii gcfvaitlma
      541 avmlvifykm rkqhhrqnhh aptrtveiin vddeitgdtp meshlpmpai ehehlnhyns
      601 ykspfnhttt vntinsihss vhepllirmn skdnvqetqi
//
LOCUS       XP_054225483             640 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 4C isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225483
VERSION     XP_054225483.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369508.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..640
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..640
                     /product="leucine-rich repeat-containing protein 4C
                     isoform X1"
                     /calculated_mol_wt=71819
     Region          47..80
                     /region_name="LRRNT"
                     /note="Leucine rich repeat N-terminal domain; smart00013"
                     /db_xref="CDD:214470"
     Region          <76..325
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          78..101
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          102..125
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          126..149
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          150..173
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          174..198
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          199..220
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          221..244
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          245..268
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          269..290
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          360..443
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          371..375
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          383..387
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          409..413
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          423..428
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          436..439
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     CDS             1..640
                     /gene="LRRC4C"
                     /gene_synonym="NGL-1; NGL1"
                     /coded_by="XM_054369508.1:926..2848"
                     /db_xref="GeneID:57689"
                     /db_xref="HGNC:HGNC:29317"
                     /db_xref="MIM:608817"
ORIGIN      
        1 mlnkmtlhpq qimigprfnr alfdpllvvl lalqllvvag lvraqtcpsv cscsnqfskv
       61 icvrknlrev pdgistntrl lnlhenqiqi ikvnsfkhlr hleilqlsrn hirtieigaf
      121 nglanlntle lfdnrlttip ngafvylskl kelwlrnnpi esipsyafnr ipslrrldlg
      181 elkrlsyise gafeglsnlr ylnlamcnlr eipnltplik ldeldlsgnh lsairpgsfq
      241 glmhlqklwm iqsqiqvier nafdnlqslv einlahnnlt llphdlftpl hhlerihlhh
      301 npwncncdil wlswwikdma psntaccarc ntppnlkgry igeldqnyft cyapvivepp
      361 adlnvtegma aelkcrasts ltsvswitpn gtvmthgayk vriavlsdgt lnftnvtvqd
      421 tgmytcmvsn svgnttasat lnvtaatttp fsyfstvtve tmepsqdear ttdnnvgptp
      481 vvdwettnvt tsltpqstrs tektftipvt dinsgipgid evmkttkiii gcfvaitlma
      541 avmlvifykm rkqhhrqnhh aptrtveiin vddeitgdtp meshlpmpai ehehlnhyns
      601 ykspfnhttt vntinsihss vhepllirmn skdnvqetqi
//
LOCUS       XP_054225484             640 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 4C isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225484
VERSION     XP_054225484.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369509.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..640
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..640
                     /product="leucine-rich repeat-containing protein 4C
                     isoform X1"
                     /calculated_mol_wt=71819
     Region          47..80
                     /region_name="LRRNT"
                     /note="Leucine rich repeat N-terminal domain; smart00013"
                     /db_xref="CDD:214470"
     Region          <76..325
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          78..101
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          102..125
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          126..149
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          150..173
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          174..198
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          199..220
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          221..244
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          245..268
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          269..290
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          360..443
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          371..375
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          383..387
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          409..413
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          423..428
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          436..439
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     CDS             1..640
                     /gene="LRRC4C"
                     /gene_synonym="NGL-1; NGL1"
                     /coded_by="XM_054369509.1:638..2560"
                     /db_xref="GeneID:57689"
                     /db_xref="HGNC:HGNC:29317"
                     /db_xref="MIM:608817"
ORIGIN      
        1 mlnkmtlhpq qimigprfnr alfdpllvvl lalqllvvag lvraqtcpsv cscsnqfskv
       61 icvrknlrev pdgistntrl lnlhenqiqi ikvnsfkhlr hleilqlsrn hirtieigaf
      121 nglanlntle lfdnrlttip ngafvylskl kelwlrnnpi esipsyafnr ipslrrldlg
      181 elkrlsyise gafeglsnlr ylnlamcnlr eipnltplik ldeldlsgnh lsairpgsfq
      241 glmhlqklwm iqsqiqvier nafdnlqslv einlahnnlt llphdlftpl hhlerihlhh
      301 npwncncdil wlswwikdma psntaccarc ntppnlkgry igeldqnyft cyapvivepp
      361 adlnvtegma aelkcrasts ltsvswitpn gtvmthgayk vriavlsdgt lnftnvtvqd
      421 tgmytcmvsn svgnttasat lnvtaatttp fsyfstvtve tmepsqdear ttdnnvgptp
      481 vvdwettnvt tsltpqstrs tektftipvt dinsgipgid evmkttkiii gcfvaitlma
      541 avmlvifykm rkqhhrqnhh aptrtveiin vddeitgdtp meshlpmpai ehehlnhyns
      601 ykspfnhttt vntinsihss vhepllirmn skdnvqetqi
//
LOCUS       XP_054225485             640 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 4C isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225485
VERSION     XP_054225485.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369510.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..640
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..640
                     /product="leucine-rich repeat-containing protein 4C
                     isoform X1"
                     /calculated_mol_wt=71819
     Region          47..80
                     /region_name="LRRNT"
                     /note="Leucine rich repeat N-terminal domain; smart00013"
                     /db_xref="CDD:214470"
     Region          <76..325
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          78..101
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          102..125
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          126..149
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          150..173
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          174..198
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          199..220
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          221..244
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          245..268
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          269..290
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          360..443
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          371..375
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          383..387
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          409..413
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          423..428
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          436..439
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     CDS             1..640
                     /gene="LRRC4C"
                     /gene_synonym="NGL-1; NGL1"
                     /coded_by="XM_054369510.1:992..2914"
                     /db_xref="GeneID:57689"
                     /db_xref="HGNC:HGNC:29317"
                     /db_xref="MIM:608817"
ORIGIN      
        1 mlnkmtlhpq qimigprfnr alfdpllvvl lalqllvvag lvraqtcpsv cscsnqfskv
       61 icvrknlrev pdgistntrl lnlhenqiqi ikvnsfkhlr hleilqlsrn hirtieigaf
      121 nglanlntle lfdnrlttip ngafvylskl kelwlrnnpi esipsyafnr ipslrrldlg
      181 elkrlsyise gafeglsnlr ylnlamcnlr eipnltplik ldeldlsgnh lsairpgsfq
      241 glmhlqklwm iqsqiqvier nafdnlqslv einlahnnlt llphdlftpl hhlerihlhh
      301 npwncncdil wlswwikdma psntaccarc ntppnlkgry igeldqnyft cyapvivepp
      361 adlnvtegma aelkcrasts ltsvswitpn gtvmthgayk vriavlsdgt lnftnvtvqd
      421 tgmytcmvsn svgnttasat lnvtaatttp fsyfstvtve tmepsqdear ttdnnvgptp
      481 vvdwettnvt tsltpqstrs tektftipvt dinsgipgid evmkttkiii gcfvaitlma
      541 avmlvifykm rkqhhrqnhh aptrtveiin vddeitgdtp meshlpmpai ehehlnhyns
      601 ykspfnhttt vntinsihss vhepllirmn skdnvqetqi
//
LOCUS       XP_054225486             640 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 4C isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225486
VERSION     XP_054225486.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369511.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..640
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..640
                     /product="leucine-rich repeat-containing protein 4C
                     isoform X1"
                     /calculated_mol_wt=71819
     Region          47..80
                     /region_name="LRRNT"
                     /note="Leucine rich repeat N-terminal domain; smart00013"
                     /db_xref="CDD:214470"
     Region          <76..325
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          78..101
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          102..125
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          126..149
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          150..173
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          174..198
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          199..220
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          221..244
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          245..268
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          269..290
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          360..443
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          371..375
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          383..387
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          409..413
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          423..428
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          436..439
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     CDS             1..640
                     /gene="LRRC4C"
                     /gene_synonym="NGL-1; NGL1"
                     /coded_by="XM_054369511.1:1540..3462"
                     /db_xref="GeneID:57689"
                     /db_xref="HGNC:HGNC:29317"
                     /db_xref="MIM:608817"
ORIGIN      
        1 mlnkmtlhpq qimigprfnr alfdpllvvl lalqllvvag lvraqtcpsv cscsnqfskv
       61 icvrknlrev pdgistntrl lnlhenqiqi ikvnsfkhlr hleilqlsrn hirtieigaf
      121 nglanlntle lfdnrlttip ngafvylskl kelwlrnnpi esipsyafnr ipslrrldlg
      181 elkrlsyise gafeglsnlr ylnlamcnlr eipnltplik ldeldlsgnh lsairpgsfq
      241 glmhlqklwm iqsqiqvier nafdnlqslv einlahnnlt llphdlftpl hhlerihlhh
      301 npwncncdil wlswwikdma psntaccarc ntppnlkgry igeldqnyft cyapvivepp
      361 adlnvtegma aelkcrasts ltsvswitpn gtvmthgayk vriavlsdgt lnftnvtvqd
      421 tgmytcmvsn svgnttasat lnvtaatttp fsyfstvtve tmepsqdear ttdnnvgptp
      481 vvdwettnvt tsltpqstrs tektftipvt dinsgipgid evmkttkiii gcfvaitlma
      541 avmlvifykm rkqhhrqnhh aptrtveiin vddeitgdtp meshlpmpai ehehlnhyns
      601 ykspfnhttt vntinsihss vhepllirmn skdnvqetqi
//
LOCUS       XP_054225487             640 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 4C isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225487
VERSION     XP_054225487.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369512.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..640
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..640
                     /product="leucine-rich repeat-containing protein 4C
                     isoform X1"
                     /calculated_mol_wt=71819
     Region          47..80
                     /region_name="LRRNT"
                     /note="Leucine rich repeat N-terminal domain; smart00013"
                     /db_xref="CDD:214470"
     Region          <76..325
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          78..101
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          102..125
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          126..149
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          150..173
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          174..198
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          199..220
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          221..244
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          245..268
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          269..290
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          360..443
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          371..375
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          383..387
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          409..413
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          423..428
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          436..439
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     CDS             1..640
                     /gene="LRRC4C"
                     /gene_synonym="NGL-1; NGL1"
                     /coded_by="XM_054369512.1:15654..17576"
                     /db_xref="GeneID:57689"
                     /db_xref="HGNC:HGNC:29317"
                     /db_xref="MIM:608817"
ORIGIN      
        1 mlnkmtlhpq qimigprfnr alfdpllvvl lalqllvvag lvraqtcpsv cscsnqfskv
       61 icvrknlrev pdgistntrl lnlhenqiqi ikvnsfkhlr hleilqlsrn hirtieigaf
      121 nglanlntle lfdnrlttip ngafvylskl kelwlrnnpi esipsyafnr ipslrrldlg
      181 elkrlsyise gafeglsnlr ylnlamcnlr eipnltplik ldeldlsgnh lsairpgsfq
      241 glmhlqklwm iqsqiqvier nafdnlqslv einlahnnlt llphdlftpl hhlerihlhh
      301 npwncncdil wlswwikdma psntaccarc ntppnlkgry igeldqnyft cyapvivepp
      361 adlnvtegma aelkcrasts ltsvswitpn gtvmthgayk vriavlsdgt lnftnvtvqd
      421 tgmytcmvsn svgnttasat lnvtaatttp fsyfstvtve tmepsqdear ttdnnvgptp
      481 vvdwettnvt tsltpqstrs tektftipvt dinsgipgid evmkttkiii gcfvaitlma
      541 avmlvifykm rkqhhrqnhh aptrtveiin vddeitgdtp meshlpmpai ehehlnhyns
      601 ykspfnhttt vntinsihss vhepllirmn skdnvqetqi
//
LOCUS       XP_054225488             640 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 4C isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225488
VERSION     XP_054225488.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369513.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..640
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..640
                     /product="leucine-rich repeat-containing protein 4C
                     isoform X1"
                     /calculated_mol_wt=71819
     Region          47..80
                     /region_name="LRRNT"
                     /note="Leucine rich repeat N-terminal domain; smart00013"
                     /db_xref="CDD:214470"
     Region          <76..325
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          78..101
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          102..125
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          126..149
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          150..173
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          174..198
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          199..220
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          221..244
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          245..268
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          269..290
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          360..443
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          371..375
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          383..387
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          409..413
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          423..428
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          436..439
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     CDS             1..640
                     /gene="LRRC4C"
                     /gene_synonym="NGL-1; NGL1"
                     /coded_by="XM_054369513.1:1141..3063"
                     /db_xref="GeneID:57689"
                     /db_xref="HGNC:HGNC:29317"
                     /db_xref="MIM:608817"
ORIGIN      
        1 mlnkmtlhpq qimigprfnr alfdpllvvl lalqllvvag lvraqtcpsv cscsnqfskv
       61 icvrknlrev pdgistntrl lnlhenqiqi ikvnsfkhlr hleilqlsrn hirtieigaf
      121 nglanlntle lfdnrlttip ngafvylskl kelwlrnnpi esipsyafnr ipslrrldlg
      181 elkrlsyise gafeglsnlr ylnlamcnlr eipnltplik ldeldlsgnh lsairpgsfq
      241 glmhlqklwm iqsqiqvier nafdnlqslv einlahnnlt llphdlftpl hhlerihlhh
      301 npwncncdil wlswwikdma psntaccarc ntppnlkgry igeldqnyft cyapvivepp
      361 adlnvtegma aelkcrasts ltsvswitpn gtvmthgayk vriavlsdgt lnftnvtvqd
      421 tgmytcmvsn svgnttasat lnvtaatttp fsyfstvtve tmepsqdear ttdnnvgptp
      481 vvdwettnvt tsltpqstrs tektftipvt dinsgipgid evmkttkiii gcfvaitlma
      541 avmlvifykm rkqhhrqnhh aptrtveiin vddeitgdtp meshlpmpai ehehlnhyns
      601 ykspfnhttt vntinsihss vhepllirmn skdnvqetqi
//
LOCUS       XP_054225489             640 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 4C isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225489
VERSION     XP_054225489.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369514.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..640
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..640
                     /product="leucine-rich repeat-containing protein 4C
                     isoform X1"
                     /calculated_mol_wt=71819
     Region          47..80
                     /region_name="LRRNT"
                     /note="Leucine rich repeat N-terminal domain; smart00013"
                     /db_xref="CDD:214470"
     Region          <76..325
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          78..101
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          102..125
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          126..149
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          150..173
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          174..198
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          199..220
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          221..244
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          245..268
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          269..290
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          360..443
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          371..375
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          383..387
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          409..413
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          423..428
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          436..439
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     CDS             1..640
                     /gene="LRRC4C"
                     /gene_synonym="NGL-1; NGL1"
                     /coded_by="XM_054369514.1:17820..19742"
                     /db_xref="GeneID:57689"
                     /db_xref="HGNC:HGNC:29317"
                     /db_xref="MIM:608817"
ORIGIN      
        1 mlnkmtlhpq qimigprfnr alfdpllvvl lalqllvvag lvraqtcpsv cscsnqfskv
       61 icvrknlrev pdgistntrl lnlhenqiqi ikvnsfkhlr hleilqlsrn hirtieigaf
      121 nglanlntle lfdnrlttip ngafvylskl kelwlrnnpi esipsyafnr ipslrrldlg
      181 elkrlsyise gafeglsnlr ylnlamcnlr eipnltplik ldeldlsgnh lsairpgsfq
      241 glmhlqklwm iqsqiqvier nafdnlqslv einlahnnlt llphdlftpl hhlerihlhh
      301 npwncncdil wlswwikdma psntaccarc ntppnlkgry igeldqnyft cyapvivepp
      361 adlnvtegma aelkcrasts ltsvswitpn gtvmthgayk vriavlsdgt lnftnvtvqd
      421 tgmytcmvsn svgnttasat lnvtaatttp fsyfstvtve tmepsqdear ttdnnvgptp
      481 vvdwettnvt tsltpqstrs tektftipvt dinsgipgid evmkttkiii gcfvaitlma
      541 avmlvifykm rkqhhrqnhh aptrtveiin vddeitgdtp meshlpmpai ehehlnhyns
      601 ykspfnhttt vntinsihss vhepllirmn skdnvqetqi
//
LOCUS       XP_054225490             640 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 4C isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225490
VERSION     XP_054225490.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369515.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..640
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..640
                     /product="leucine-rich repeat-containing protein 4C
                     isoform X1"
                     /calculated_mol_wt=71819
     Region          47..80
                     /region_name="LRRNT"
                     /note="Leucine rich repeat N-terminal domain; smart00013"
                     /db_xref="CDD:214470"
     Region          <76..325
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          78..101
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          102..125
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          126..149
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          150..173
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          174..198
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          199..220
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          221..244
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          245..268
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          269..290
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          360..443
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          371..375
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          383..387
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          409..413
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          423..428
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          436..439
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     CDS             1..640
                     /gene="LRRC4C"
                     /gene_synonym="NGL-1; NGL1"
                     /coded_by="XM_054369515.1:585..2507"
                     /db_xref="GeneID:57689"
                     /db_xref="HGNC:HGNC:29317"
                     /db_xref="MIM:608817"
ORIGIN      
        1 mlnkmtlhpq qimigprfnr alfdpllvvl lalqllvvag lvraqtcpsv cscsnqfskv
       61 icvrknlrev pdgistntrl lnlhenqiqi ikvnsfkhlr hleilqlsrn hirtieigaf
      121 nglanlntle lfdnrlttip ngafvylskl kelwlrnnpi esipsyafnr ipslrrldlg
      181 elkrlsyise gafeglsnlr ylnlamcnlr eipnltplik ldeldlsgnh lsairpgsfq
      241 glmhlqklwm iqsqiqvier nafdnlqslv einlahnnlt llphdlftpl hhlerihlhh
      301 npwncncdil wlswwikdma psntaccarc ntppnlkgry igeldqnyft cyapvivepp
      361 adlnvtegma aelkcrasts ltsvswitpn gtvmthgayk vriavlsdgt lnftnvtvqd
      421 tgmytcmvsn svgnttasat lnvtaatttp fsyfstvtve tmepsqdear ttdnnvgptp
      481 vvdwettnvt tsltpqstrs tektftipvt dinsgipgid evmkttkiii gcfvaitlma
      541 avmlvifykm rkqhhrqnhh aptrtveiin vddeitgdtp meshlpmpai ehehlnhyns
      601 ykspfnhttt vntinsihss vhepllirmn skdnvqetqi
//
LOCUS       XP_054225491             640 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 4C isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225491
VERSION     XP_054225491.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369516.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..640
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..640
                     /product="leucine-rich repeat-containing protein 4C
                     isoform X1"
                     /calculated_mol_wt=71819
     Region          47..80
                     /region_name="LRRNT"
                     /note="Leucine rich repeat N-terminal domain; smart00013"
                     /db_xref="CDD:214470"
     Region          <76..325
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          78..101
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          102..125
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          126..149
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          150..173
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          174..198
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          199..220
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          221..244
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          245..268
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          269..290
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          360..443
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          371..375
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          383..387
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          409..413
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          423..428
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          436..439
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     CDS             1..640
                     /gene="LRRC4C"
                     /gene_synonym="NGL-1; NGL1"
                     /coded_by="XM_054369516.1:877..2799"
                     /db_xref="GeneID:57689"
                     /db_xref="HGNC:HGNC:29317"
                     /db_xref="MIM:608817"
ORIGIN      
        1 mlnkmtlhpq qimigprfnr alfdpllvvl lalqllvvag lvraqtcpsv cscsnqfskv
       61 icvrknlrev pdgistntrl lnlhenqiqi ikvnsfkhlr hleilqlsrn hirtieigaf
      121 nglanlntle lfdnrlttip ngafvylskl kelwlrnnpi esipsyafnr ipslrrldlg
      181 elkrlsyise gafeglsnlr ylnlamcnlr eipnltplik ldeldlsgnh lsairpgsfq
      241 glmhlqklwm iqsqiqvier nafdnlqslv einlahnnlt llphdlftpl hhlerihlhh
      301 npwncncdil wlswwikdma psntaccarc ntppnlkgry igeldqnyft cyapvivepp
      361 adlnvtegma aelkcrasts ltsvswitpn gtvmthgayk vriavlsdgt lnftnvtvqd
      421 tgmytcmvsn svgnttasat lnvtaatttp fsyfstvtve tmepsqdear ttdnnvgptp
      481 vvdwettnvt tsltpqstrs tektftipvt dinsgipgid evmkttkiii gcfvaitlma
      541 avmlvifykm rkqhhrqnhh aptrtveiin vddeitgdtp meshlpmpai ehehlnhyns
      601 ykspfnhttt vntinsihss vhepllirmn skdnvqetqi
//
LOCUS       XP_054225492             640 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 4C isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225492
VERSION     XP_054225492.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369517.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..640
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..640
                     /product="leucine-rich repeat-containing protein 4C
                     isoform X1"
                     /calculated_mol_wt=71819
     Region          47..80
                     /region_name="LRRNT"
                     /note="Leucine rich repeat N-terminal domain; smart00013"
                     /db_xref="CDD:214470"
     Region          <76..325
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          78..101
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          102..125
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          126..149
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          150..173
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          174..198
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          199..220
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          221..244
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          245..268
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          269..290
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          360..443
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          371..375
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          383..387
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          409..413
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          423..428
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          436..439
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     CDS             1..640
                     /gene="LRRC4C"
                     /gene_synonym="NGL-1; NGL1"
                     /coded_by="XM_054369517.1:1114..3036"
                     /db_xref="GeneID:57689"
                     /db_xref="HGNC:HGNC:29317"
                     /db_xref="MIM:608817"
ORIGIN      
        1 mlnkmtlhpq qimigprfnr alfdpllvvl lalqllvvag lvraqtcpsv cscsnqfskv
       61 icvrknlrev pdgistntrl lnlhenqiqi ikvnsfkhlr hleilqlsrn hirtieigaf
      121 nglanlntle lfdnrlttip ngafvylskl kelwlrnnpi esipsyafnr ipslrrldlg
      181 elkrlsyise gafeglsnlr ylnlamcnlr eipnltplik ldeldlsgnh lsairpgsfq
      241 glmhlqklwm iqsqiqvier nafdnlqslv einlahnnlt llphdlftpl hhlerihlhh
      301 npwncncdil wlswwikdma psntaccarc ntppnlkgry igeldqnyft cyapvivepp
      361 adlnvtegma aelkcrasts ltsvswitpn gtvmthgayk vriavlsdgt lnftnvtvqd
      421 tgmytcmvsn svgnttasat lnvtaatttp fsyfstvtve tmepsqdear ttdnnvgptp
      481 vvdwettnvt tsltpqstrs tektftipvt dinsgipgid evmkttkiii gcfvaitlma
      541 avmlvifykm rkqhhrqnhh aptrtveiin vddeitgdtp meshlpmpai ehehlnhyns
      601 ykspfnhttt vntinsihss vhepllirmn skdnvqetqi
//
LOCUS       XP_054225493             640 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 4C isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225493
VERSION     XP_054225493.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369518.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..640
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..640
                     /product="leucine-rich repeat-containing protein 4C
                     isoform X1"
                     /calculated_mol_wt=71819
     Region          47..80
                     /region_name="LRRNT"
                     /note="Leucine rich repeat N-terminal domain; smart00013"
                     /db_xref="CDD:214470"
     Region          <76..325
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          78..101
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          102..125
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          126..149
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          150..173
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          174..198
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          199..220
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          221..244
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          245..268
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          269..290
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          360..443
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          371..375
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          383..387
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          409..413
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          423..428
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          436..439
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     CDS             1..640
                     /gene="LRRC4C"
                     /gene_synonym="NGL-1; NGL1"
                     /coded_by="XM_054369518.1:1100..3022"
                     /db_xref="GeneID:57689"
                     /db_xref="HGNC:HGNC:29317"
                     /db_xref="MIM:608817"
ORIGIN      
        1 mlnkmtlhpq qimigprfnr alfdpllvvl lalqllvvag lvraqtcpsv cscsnqfskv
       61 icvrknlrev pdgistntrl lnlhenqiqi ikvnsfkhlr hleilqlsrn hirtieigaf
      121 nglanlntle lfdnrlttip ngafvylskl kelwlrnnpi esipsyafnr ipslrrldlg
      181 elkrlsyise gafeglsnlr ylnlamcnlr eipnltplik ldeldlsgnh lsairpgsfq
      241 glmhlqklwm iqsqiqvier nafdnlqslv einlahnnlt llphdlftpl hhlerihlhh
      301 npwncncdil wlswwikdma psntaccarc ntppnlkgry igeldqnyft cyapvivepp
      361 adlnvtegma aelkcrasts ltsvswitpn gtvmthgayk vriavlsdgt lnftnvtvqd
      421 tgmytcmvsn svgnttasat lnvtaatttp fsyfstvtve tmepsqdear ttdnnvgptp
      481 vvdwettnvt tsltpqstrs tektftipvt dinsgipgid evmkttkiii gcfvaitlma
      541 avmlvifykm rkqhhrqnhh aptrtveiin vddeitgdtp meshlpmpai ehehlnhyns
      601 ykspfnhttt vntinsihss vhepllirmn skdnvqetqi
//
LOCUS       XP_054225494             640 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 4C isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225494
VERSION     XP_054225494.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369519.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..640
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..640
                     /product="leucine-rich repeat-containing protein 4C
                     isoform X1"
                     /calculated_mol_wt=71819
     Region          47..80
                     /region_name="LRRNT"
                     /note="Leucine rich repeat N-terminal domain; smart00013"
                     /db_xref="CDD:214470"
     Region          <76..325
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          78..101
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          102..125
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          126..149
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          150..173
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          174..198
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          199..220
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          221..244
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          245..268
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          269..290
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          360..443
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          371..375
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          383..387
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          409..413
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          423..428
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          436..439
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     CDS             1..640
                     /gene="LRRC4C"
                     /gene_synonym="NGL-1; NGL1"
                     /coded_by="XM_054369519.1:1095..3017"
                     /db_xref="GeneID:57689"
                     /db_xref="HGNC:HGNC:29317"
                     /db_xref="MIM:608817"
ORIGIN      
        1 mlnkmtlhpq qimigprfnr alfdpllvvl lalqllvvag lvraqtcpsv cscsnqfskv
       61 icvrknlrev pdgistntrl lnlhenqiqi ikvnsfkhlr hleilqlsrn hirtieigaf
      121 nglanlntle lfdnrlttip ngafvylskl kelwlrnnpi esipsyafnr ipslrrldlg
      181 elkrlsyise gafeglsnlr ylnlamcnlr eipnltplik ldeldlsgnh lsairpgsfq
      241 glmhlqklwm iqsqiqvier nafdnlqslv einlahnnlt llphdlftpl hhlerihlhh
      301 npwncncdil wlswwikdma psntaccarc ntppnlkgry igeldqnyft cyapvivepp
      361 adlnvtegma aelkcrasts ltsvswitpn gtvmthgayk vriavlsdgt lnftnvtvqd
      421 tgmytcmvsn svgnttasat lnvtaatttp fsyfstvtve tmepsqdear ttdnnvgptp
      481 vvdwettnvt tsltpqstrs tektftipvt dinsgipgid evmkttkiii gcfvaitlma
      541 avmlvifykm rkqhhrqnhh aptrtveiin vddeitgdtp meshlpmpai ehehlnhyns
      601 ykspfnhttt vntinsihss vhepllirmn skdnvqetqi
//
LOCUS       XP_054225495             640 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 4C isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225495
VERSION     XP_054225495.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369520.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..640
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..640
                     /product="leucine-rich repeat-containing protein 4C
                     isoform X1"
                     /calculated_mol_wt=71819
     Region          47..80
                     /region_name="LRRNT"
                     /note="Leucine rich repeat N-terminal domain; smart00013"
                     /db_xref="CDD:214470"
     Region          <76..325
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          78..101
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          102..125
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          126..149
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          150..173
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          174..198
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          199..220
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          221..244
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          245..268
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          269..290
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          360..443
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          371..375
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          383..387
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          409..413
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          423..428
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          436..439
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     CDS             1..640
                     /gene="LRRC4C"
                     /gene_synonym="NGL-1; NGL1"
                     /coded_by="XM_054369520.1:930..2852"
                     /db_xref="GeneID:57689"
                     /db_xref="HGNC:HGNC:29317"
                     /db_xref="MIM:608817"
ORIGIN      
        1 mlnkmtlhpq qimigprfnr alfdpllvvl lalqllvvag lvraqtcpsv cscsnqfskv
       61 icvrknlrev pdgistntrl lnlhenqiqi ikvnsfkhlr hleilqlsrn hirtieigaf
      121 nglanlntle lfdnrlttip ngafvylskl kelwlrnnpi esipsyafnr ipslrrldlg
      181 elkrlsyise gafeglsnlr ylnlamcnlr eipnltplik ldeldlsgnh lsairpgsfq
      241 glmhlqklwm iqsqiqvier nafdnlqslv einlahnnlt llphdlftpl hhlerihlhh
      301 npwncncdil wlswwikdma psntaccarc ntppnlkgry igeldqnyft cyapvivepp
      361 adlnvtegma aelkcrasts ltsvswitpn gtvmthgayk vriavlsdgt lnftnvtvqd
      421 tgmytcmvsn svgnttasat lnvtaatttp fsyfstvtve tmepsqdear ttdnnvgptp
      481 vvdwettnvt tsltpqstrs tektftipvt dinsgipgid evmkttkiii gcfvaitlma
      541 avmlvifykm rkqhhrqnhh aptrtveiin vddeitgdtp meshlpmpai ehehlnhyns
      601 ykspfnhttt vntinsihss vhepllirmn skdnvqetqi
//
LOCUS       XP_054225496             640 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 4C isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225496
VERSION     XP_054225496.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369521.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..640
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..640
                     /product="leucine-rich repeat-containing protein 4C
                     isoform X1"
                     /calculated_mol_wt=71819
     Region          47..80
                     /region_name="LRRNT"
                     /note="Leucine rich repeat N-terminal domain; smart00013"
                     /db_xref="CDD:214470"
     Region          <76..325
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          78..101
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          102..125
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          126..149
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          150..173
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          174..198
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          199..220
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          221..244
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          245..268
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          269..290
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          360..443
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          371..375
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          383..387
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          409..413
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          423..428
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          436..439
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     CDS             1..640
                     /gene="LRRC4C"
                     /gene_synonym="NGL-1; NGL1"
                     /coded_by="XM_054369521.1:996..2918"
                     /db_xref="GeneID:57689"
                     /db_xref="HGNC:HGNC:29317"
                     /db_xref="MIM:608817"
ORIGIN      
        1 mlnkmtlhpq qimigprfnr alfdpllvvl lalqllvvag lvraqtcpsv cscsnqfskv
       61 icvrknlrev pdgistntrl lnlhenqiqi ikvnsfkhlr hleilqlsrn hirtieigaf
      121 nglanlntle lfdnrlttip ngafvylskl kelwlrnnpi esipsyafnr ipslrrldlg
      181 elkrlsyise gafeglsnlr ylnlamcnlr eipnltplik ldeldlsgnh lsairpgsfq
      241 glmhlqklwm iqsqiqvier nafdnlqslv einlahnnlt llphdlftpl hhlerihlhh
      301 npwncncdil wlswwikdma psntaccarc ntppnlkgry igeldqnyft cyapvivepp
      361 adlnvtegma aelkcrasts ltsvswitpn gtvmthgayk vriavlsdgt lnftnvtvqd
      421 tgmytcmvsn svgnttasat lnvtaatttp fsyfstvtve tmepsqdear ttdnnvgptp
      481 vvdwettnvt tsltpqstrs tektftipvt dinsgipgid evmkttkiii gcfvaitlma
      541 avmlvifykm rkqhhrqnhh aptrtveiin vddeitgdtp meshlpmpai ehehlnhyns
      601 ykspfnhttt vntinsihss vhepllirmn skdnvqetqi
//
LOCUS       XP_054225497             640 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 4C isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225497
VERSION     XP_054225497.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369522.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..640
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..640
                     /product="leucine-rich repeat-containing protein 4C
                     isoform X1"
                     /calculated_mol_wt=71819
     Region          47..80
                     /region_name="LRRNT"
                     /note="Leucine rich repeat N-terminal domain; smart00013"
                     /db_xref="CDD:214470"
     Region          <76..325
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          78..101
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          102..125
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          126..149
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          150..173
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          174..198
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          199..220
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          221..244
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          245..268
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          269..290
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          360..443
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          371..375
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          383..387
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          409..413
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          423..428
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          436..439
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     CDS             1..640
                     /gene="LRRC4C"
                     /gene_synonym="NGL-1; NGL1"
                     /coded_by="XM_054369522.1:916..2838"
                     /db_xref="GeneID:57689"
                     /db_xref="HGNC:HGNC:29317"
                     /db_xref="MIM:608817"
ORIGIN      
        1 mlnkmtlhpq qimigprfnr alfdpllvvl lalqllvvag lvraqtcpsv cscsnqfskv
       61 icvrknlrev pdgistntrl lnlhenqiqi ikvnsfkhlr hleilqlsrn hirtieigaf
      121 nglanlntle lfdnrlttip ngafvylskl kelwlrnnpi esipsyafnr ipslrrldlg
      181 elkrlsyise gafeglsnlr ylnlamcnlr eipnltplik ldeldlsgnh lsairpgsfq
      241 glmhlqklwm iqsqiqvier nafdnlqslv einlahnnlt llphdlftpl hhlerihlhh
      301 npwncncdil wlswwikdma psntaccarc ntppnlkgry igeldqnyft cyapvivepp
      361 adlnvtegma aelkcrasts ltsvswitpn gtvmthgayk vriavlsdgt lnftnvtvqd
      421 tgmytcmvsn svgnttasat lnvtaatttp fsyfstvtve tmepsqdear ttdnnvgptp
      481 vvdwettnvt tsltpqstrs tektftipvt dinsgipgid evmkttkiii gcfvaitlma
      541 avmlvifykm rkqhhrqnhh aptrtveiin vddeitgdtp meshlpmpai ehehlnhyns
      601 ykspfnhttt vntinsihss vhepllirmn skdnvqetqi
//
LOCUS       XP_054225498             640 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 4C isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225498
VERSION     XP_054225498.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369523.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..640
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..640
                     /product="leucine-rich repeat-containing protein 4C
                     isoform X1"
                     /calculated_mol_wt=71819
     Region          47..80
                     /region_name="LRRNT"
                     /note="Leucine rich repeat N-terminal domain; smart00013"
                     /db_xref="CDD:214470"
     Region          <76..325
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          78..101
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          102..125
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          126..149
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          150..173
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          174..198
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          199..220
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          221..244
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          245..268
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          269..290
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          360..443
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          371..375
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          383..387
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          409..413
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          423..428
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          436..439
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     CDS             1..640
                     /gene="LRRC4C"
                     /gene_synonym="NGL-1; NGL1"
                     /coded_by="XM_054369523.1:665..2587"
                     /db_xref="GeneID:57689"
                     /db_xref="HGNC:HGNC:29317"
                     /db_xref="MIM:608817"
ORIGIN      
        1 mlnkmtlhpq qimigprfnr alfdpllvvl lalqllvvag lvraqtcpsv cscsnqfskv
       61 icvrknlrev pdgistntrl lnlhenqiqi ikvnsfkhlr hleilqlsrn hirtieigaf
      121 nglanlntle lfdnrlttip ngafvylskl kelwlrnnpi esipsyafnr ipslrrldlg
      181 elkrlsyise gafeglsnlr ylnlamcnlr eipnltplik ldeldlsgnh lsairpgsfq
      241 glmhlqklwm iqsqiqvier nafdnlqslv einlahnnlt llphdlftpl hhlerihlhh
      301 npwncncdil wlswwikdma psntaccarc ntppnlkgry igeldqnyft cyapvivepp
      361 adlnvtegma aelkcrasts ltsvswitpn gtvmthgayk vriavlsdgt lnftnvtvqd
      421 tgmytcmvsn svgnttasat lnvtaatttp fsyfstvtve tmepsqdear ttdnnvgptp
      481 vvdwettnvt tsltpqstrs tektftipvt dinsgipgid evmkttkiii gcfvaitlma
      541 avmlvifykm rkqhhrqnhh aptrtveiin vddeitgdtp meshlpmpai ehehlnhyns
      601 ykspfnhttt vntinsihss vhepllirmn skdnvqetqi
//
LOCUS       XP_054225499             640 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 4C isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225499
VERSION     XP_054225499.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369524.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..640
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..640
                     /product="leucine-rich repeat-containing protein 4C
                     isoform X1"
                     /calculated_mol_wt=71819
     Region          47..80
                     /region_name="LRRNT"
                     /note="Leucine rich repeat N-terminal domain; smart00013"
                     /db_xref="CDD:214470"
     Region          <76..325
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          78..101
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          102..125
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          126..149
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          150..173
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          174..198
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          199..220
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          221..244
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          245..268
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          269..290
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          360..443
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          371..375
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          383..387
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          409..413
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          423..428
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          436..439
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     CDS             1..640
                     /gene="LRRC4C"
                     /gene_synonym="NGL-1; NGL1"
                     /coded_by="XM_054369524.1:797..2719"
                     /db_xref="GeneID:57689"
                     /db_xref="HGNC:HGNC:29317"
                     /db_xref="MIM:608817"
ORIGIN      
        1 mlnkmtlhpq qimigprfnr alfdpllvvl lalqllvvag lvraqtcpsv cscsnqfskv
       61 icvrknlrev pdgistntrl lnlhenqiqi ikvnsfkhlr hleilqlsrn hirtieigaf
      121 nglanlntle lfdnrlttip ngafvylskl kelwlrnnpi esipsyafnr ipslrrldlg
      181 elkrlsyise gafeglsnlr ylnlamcnlr eipnltplik ldeldlsgnh lsairpgsfq
      241 glmhlqklwm iqsqiqvier nafdnlqslv einlahnnlt llphdlftpl hhlerihlhh
      301 npwncncdil wlswwikdma psntaccarc ntppnlkgry igeldqnyft cyapvivepp
      361 adlnvtegma aelkcrasts ltsvswitpn gtvmthgayk vriavlsdgt lnftnvtvqd
      421 tgmytcmvsn svgnttasat lnvtaatttp fsyfstvtve tmepsqdear ttdnnvgptp
      481 vvdwettnvt tsltpqstrs tektftipvt dinsgipgid evmkttkiii gcfvaitlma
      541 avmlvifykm rkqhhrqnhh aptrtveiin vddeitgdtp meshlpmpai ehehlnhyns
      601 ykspfnhttt vntinsihss vhepllirmn skdnvqetqi
//
LOCUS       XP_054225500             640 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 4C isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225500
VERSION     XP_054225500.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369525.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..640
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..640
                     /product="leucine-rich repeat-containing protein 4C
                     isoform X1"
                     /calculated_mol_wt=71819
     Region          47..80
                     /region_name="LRRNT"
                     /note="Leucine rich repeat N-terminal domain; smart00013"
                     /db_xref="CDD:214470"
     Region          <76..325
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          78..101
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          102..125
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          126..149
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          150..173
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          174..198
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          199..220
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          221..244
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          245..268
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          269..290
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          360..443
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          371..375
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          383..387
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          409..413
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          423..428
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          436..439
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     CDS             1..640
                     /gene="LRRC4C"
                     /gene_synonym="NGL-1; NGL1"
                     /coded_by="XM_054369525.1:17741..19663"
                     /db_xref="GeneID:57689"
                     /db_xref="HGNC:HGNC:29317"
                     /db_xref="MIM:608817"
ORIGIN      
        1 mlnkmtlhpq qimigprfnr alfdpllvvl lalqllvvag lvraqtcpsv cscsnqfskv
       61 icvrknlrev pdgistntrl lnlhenqiqi ikvnsfkhlr hleilqlsrn hirtieigaf
      121 nglanlntle lfdnrlttip ngafvylskl kelwlrnnpi esipsyafnr ipslrrldlg
      181 elkrlsyise gafeglsnlr ylnlamcnlr eipnltplik ldeldlsgnh lsairpgsfq
      241 glmhlqklwm iqsqiqvier nafdnlqslv einlahnnlt llphdlftpl hhlerihlhh
      301 npwncncdil wlswwikdma psntaccarc ntppnlkgry igeldqnyft cyapvivepp
      361 adlnvtegma aelkcrasts ltsvswitpn gtvmthgayk vriavlsdgt lnftnvtvqd
      421 tgmytcmvsn svgnttasat lnvtaatttp fsyfstvtve tmepsqdear ttdnnvgptp
      481 vvdwettnvt tsltpqstrs tektftipvt dinsgipgid evmkttkiii gcfvaitlma
      541 avmlvifykm rkqhhrqnhh aptrtveiin vddeitgdtp meshlpmpai ehehlnhyns
      601 ykspfnhttt vntinsihss vhepllirmn skdnvqetqi
//
LOCUS       XP_054225501             640 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 4C isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225501
VERSION     XP_054225501.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369526.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..640
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..640
                     /product="leucine-rich repeat-containing protein 4C
                     isoform X1"
                     /calculated_mol_wt=71819
     Region          47..80
                     /region_name="LRRNT"
                     /note="Leucine rich repeat N-terminal domain; smart00013"
                     /db_xref="CDD:214470"
     Region          <76..325
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          78..101
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          102..125
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          126..149
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          150..173
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          174..198
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          199..220
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          221..244
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          245..268
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          269..290
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          360..443
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          371..375
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          383..387
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          409..413
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          423..428
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          436..439
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     CDS             1..640
                     /gene="LRRC4C"
                     /gene_synonym="NGL-1; NGL1"
                     /coded_by="XM_054369526.1:1180..3102"
                     /db_xref="GeneID:57689"
                     /db_xref="HGNC:HGNC:29317"
                     /db_xref="MIM:608817"
ORIGIN      
        1 mlnkmtlhpq qimigprfnr alfdpllvvl lalqllvvag lvraqtcpsv cscsnqfskv
       61 icvrknlrev pdgistntrl lnlhenqiqi ikvnsfkhlr hleilqlsrn hirtieigaf
      121 nglanlntle lfdnrlttip ngafvylskl kelwlrnnpi esipsyafnr ipslrrldlg
      181 elkrlsyise gafeglsnlr ylnlamcnlr eipnltplik ldeldlsgnh lsairpgsfq
      241 glmhlqklwm iqsqiqvier nafdnlqslv einlahnnlt llphdlftpl hhlerihlhh
      301 npwncncdil wlswwikdma psntaccarc ntppnlkgry igeldqnyft cyapvivepp
      361 adlnvtegma aelkcrasts ltsvswitpn gtvmthgayk vriavlsdgt lnftnvtvqd
      421 tgmytcmvsn svgnttasat lnvtaatttp fsyfstvtve tmepsqdear ttdnnvgptp
      481 vvdwettnvt tsltpqstrs tektftipvt dinsgipgid evmkttkiii gcfvaitlma
      541 avmlvifykm rkqhhrqnhh aptrtveiin vddeitgdtp meshlpmpai ehehlnhyns
      601 ykspfnhttt vntinsihss vhepllirmn skdnvqetqi
//
LOCUS       XP_054225502             640 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 4C isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225502
VERSION     XP_054225502.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369527.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..640
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..640
                     /product="leucine-rich repeat-containing protein 4C
                     isoform X1"
                     /calculated_mol_wt=71819
     Region          47..80
                     /region_name="LRRNT"
                     /note="Leucine rich repeat N-terminal domain; smart00013"
                     /db_xref="CDD:214470"
     Region          <76..325
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          78..101
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          102..125
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          126..149
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          150..173
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          174..198
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          199..220
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          221..244
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          245..268
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          269..290
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          360..443
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          371..375
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          383..387
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          409..413
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          423..428
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          436..439
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     CDS             1..640
                     /gene="LRRC4C"
                     /gene_synonym="NGL-1; NGL1"
                     /coded_by="XM_054369527.1:911..2833"
                     /db_xref="GeneID:57689"
                     /db_xref="HGNC:HGNC:29317"
                     /db_xref="MIM:608817"
ORIGIN      
        1 mlnkmtlhpq qimigprfnr alfdpllvvl lalqllvvag lvraqtcpsv cscsnqfskv
       61 icvrknlrev pdgistntrl lnlhenqiqi ikvnsfkhlr hleilqlsrn hirtieigaf
      121 nglanlntle lfdnrlttip ngafvylskl kelwlrnnpi esipsyafnr ipslrrldlg
      181 elkrlsyise gafeglsnlr ylnlamcnlr eipnltplik ldeldlsgnh lsairpgsfq
      241 glmhlqklwm iqsqiqvier nafdnlqslv einlahnnlt llphdlftpl hhlerihlhh
      301 npwncncdil wlswwikdma psntaccarc ntppnlkgry igeldqnyft cyapvivepp
      361 adlnvtegma aelkcrasts ltsvswitpn gtvmthgayk vriavlsdgt lnftnvtvqd
      421 tgmytcmvsn svgnttasat lnvtaatttp fsyfstvtve tmepsqdear ttdnnvgptp
      481 vvdwettnvt tsltpqstrs tektftipvt dinsgipgid evmkttkiii gcfvaitlma
      541 avmlvifykm rkqhhrqnhh aptrtveiin vddeitgdtp meshlpmpai ehehlnhyns
      601 ykspfnhttt vntinsihss vhepllirmn skdnvqetqi
//
LOCUS       XP_054225503             640 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 4C isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225503
VERSION     XP_054225503.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369528.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..640
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..640
                     /product="leucine-rich repeat-containing protein 4C
                     isoform X1"
                     /calculated_mol_wt=71819
     Region          47..80
                     /region_name="LRRNT"
                     /note="Leucine rich repeat N-terminal domain; smart00013"
                     /db_xref="CDD:214470"
     Region          <76..325
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          78..101
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          102..125
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          126..149
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          150..173
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          174..198
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          199..220
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          221..244
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          245..268
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          269..290
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          360..443
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          371..375
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          383..387
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          409..413
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          423..428
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          436..439
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     CDS             1..640
                     /gene="LRRC4C"
                     /gene_synonym="NGL-1; NGL1"
                     /coded_by="XM_054369528.1:793..2715"
                     /db_xref="GeneID:57689"
                     /db_xref="HGNC:HGNC:29317"
                     /db_xref="MIM:608817"
ORIGIN      
        1 mlnkmtlhpq qimigprfnr alfdpllvvl lalqllvvag lvraqtcpsv cscsnqfskv
       61 icvrknlrev pdgistntrl lnlhenqiqi ikvnsfkhlr hleilqlsrn hirtieigaf
      121 nglanlntle lfdnrlttip ngafvylskl kelwlrnnpi esipsyafnr ipslrrldlg
      181 elkrlsyise gafeglsnlr ylnlamcnlr eipnltplik ldeldlsgnh lsairpgsfq
      241 glmhlqklwm iqsqiqvier nafdnlqslv einlahnnlt llphdlftpl hhlerihlhh
      301 npwncncdil wlswwikdma psntaccarc ntppnlkgry igeldqnyft cyapvivepp
      361 adlnvtegma aelkcrasts ltsvswitpn gtvmthgayk vriavlsdgt lnftnvtvqd
      421 tgmytcmvsn svgnttasat lnvtaatttp fsyfstvtve tmepsqdear ttdnnvgptp
      481 vvdwettnvt tsltpqstrs tektftipvt dinsgipgid evmkttkiii gcfvaitlma
      541 avmlvifykm rkqhhrqnhh aptrtveiin vddeitgdtp meshlpmpai ehehlnhyns
      601 ykspfnhttt vntinsihss vhepllirmn skdnvqetqi
//
LOCUS       XP_054225504             640 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich repeat-containing protein 4C isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225504
VERSION     XP_054225504.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369529.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..640
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..640
                     /product="leucine-rich repeat-containing protein 4C
                     isoform X1"
                     /calculated_mol_wt=71819
     Region          47..80
                     /region_name="LRRNT"
                     /note="Leucine rich repeat N-terminal domain; smart00013"
                     /db_xref="CDD:214470"
     Region          <76..325
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          78..101
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          102..125
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          126..149
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          150..173
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          174..198
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          199..220
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          221..244
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          245..268
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          269..290
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          360..443
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          371..375
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          383..387
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          409..413
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          423..428
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          436..439
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     CDS             1..640
                     /gene="LRRC4C"
                     /gene_synonym="NGL-1; NGL1"
                     /coded_by="XM_054369529.1:1061..2983"
                     /db_xref="GeneID:57689"
                     /db_xref="HGNC:HGNC:29317"
                     /db_xref="MIM:608817"
ORIGIN      
        1 mlnkmtlhpq qimigprfnr alfdpllvvl lalqllvvag lvraqtcpsv cscsnqfskv
       61 icvrknlrev pdgistntrl lnlhenqiqi ikvnsfkhlr hleilqlsrn hirtieigaf
      121 nglanlntle lfdnrlttip ngafvylskl kelwlrnnpi esipsyafnr ipslrrldlg
      181 elkrlsyise gafeglsnlr ylnlamcnlr eipnltplik ldeldlsgnh lsairpgsfq
      241 glmhlqklwm iqsqiqvier nafdnlqslv einlahnnlt llphdlftpl hhlerihlhh
      301 npwncncdil wlswwikdma psntaccarc ntppnlkgry igeldqnyft cyapvivepp
      361 adlnvtegma aelkcrasts ltsvswitpn gtvmthgayk vriavlsdgt lnftnvtvqd
      421 tgmytcmvsn svgnttasat lnvtaatttp fsyfstvtve tmepsqdear ttdnnvgptp
      481 vvdwettnvt tsltpqstrs tektftipvt dinsgipgid evmkttkiii gcfvaitlma
      541 avmlvifykm rkqhhrqnhh aptrtveiin vddeitgdtp meshlpmpai ehehlnhyns
      601 ykspfnhttt vntinsihss vhepllirmn skdnvqetqi
//
LOCUS       XP_054225505             986 aa            linear   PRI 05-AUG-2025
DEFINITION  signal peptide, CUB and EGF-like domain-containing protein 2
            isoform X1 [Homo sapiens].
ACCESSION   XP_054225505
VERSION     XP_054225505.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369530.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..986
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..986
                     /product="signal peptide, CUB and EGF-like
                     domain-containing protein 2 isoform X1"
                     /calculated_mol_wt=108109
     Region          48..83
                     /region_name="EGF_3"
                     /note="EGF domain; pfam12947"
                     /db_xref="CDD:463759"
     Region          94..125
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          131..166
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          176..212
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          216..251
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          285..320
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          <311..360
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          <358..394
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          631..681
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          688..735
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          744..791
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          796..907
                     /region_name="CUB"
                     /note="CUB domain; extracellular domain; present in
                     proteins mostly known to be involved in development; not
                     found in prokaryotes, plants and yeast; cd00041"
                     /db_xref="CDD:238001"
     Site            order(804,806,808,835,840,878,902,904,906..907)
                     /site_type="other"
                     /note="heterodimerization interface [polypeptide binding]"
                     /db_xref="CDD:238001"
     CDS             1..986
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /coded_by="XM_054369530.1:71..3031"
                     /db_xref="GeneID:57758"
                     /db_xref="HGNC:HGNC:30425"
                     /db_xref="MIM:611747"
ORIGIN      
        1 mgvagrnrpg aawavlllll lppplllaga vppgrgraag pqedvdecaq glddchadal
       61 cqntptsykc sckpgyqgeg rqcedidecg nelnggcvhd clnipgnyrc tcfdgfmlah
      121 dghncldvde clennggcqh tcvnvmgsye ccckegffls dnqhtcihrs eeglscmnkd
      181 hgcshickea prgsvacecr pgfelaknqr dciltcnhgn ggcqhscddt adgpecschp
      241 qykmhtdgrs cleredtvle vtesnttsvv dgdkrvkrrl lmetcavnng gcdrtckdts
      301 tgvhcscpvg ftlqldgktc kdidecqtrn ggcdhfckni vgsfdcgckk gfklltdeks
      361 cqdvdecsld rtcdhscinh pgtfacacnr gytlygfthc gevkgllpts vsprvslhcg
      421 ksgggdgcfl rchsgihlss glqgaysvtc gsssplrnkq qksndsafgd vttirtsvtf
      481 klnegkcslk naelfpeglr palpekhssv kesfryvnlt cssgkqvpga pgrpstpkem
      541 fitvefelet nqkevtascd lscivkrtek rlrkairtlr kavhreqfhl qlsgmnldva
      601 kkpprtserq aescgvgqgh aenqcvscra gtyydgarer cilcpngtfq neegqmtcep
      661 cprpgnsgal ktpeawnmse cgglcqpgey sadgfapcql calgtfqpea grtscfpcgg
      721 glatkhqgat sfqdcetrvq cspghfyntt thrcircpvg tyqpefgknn cvscpgnttt
      781 dfdgstnitq cknrrcggel gdftgyiesp nypgnypant ectwtinppp krrilivvpe
      841 iflpieddcg dylvmrktss snsvttyetc qtyerpiaft srskklwiqf ksnegnsarg
      901 fqvpyvtyde dyqeliediv rdgrlyasen hqeilkdkkl ikalfdvlah pqnyfkytaq
      961 esremfprsf irllrskvsr flrpyk
//
LOCUS       XP_054225506             961 aa            linear   PRI 05-AUG-2025
DEFINITION  signal peptide, CUB and EGF-like domain-containing protein 2
            isoform X2 [Homo sapiens].
ACCESSION   XP_054225506
VERSION     XP_054225506.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369531.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..961
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..961
                     /product="signal peptide, CUB and EGF-like
                     domain-containing protein 2 isoform X2"
                     /calculated_mol_wt=105182
     Region          48..83
                     /region_name="EGF_3"
                     /note="EGF domain; pfam12947"
                     /db_xref="CDD:463759"
     Region          94..125
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          131..166
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          176..212
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          216..251
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          285..320
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          <311..360
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          <358..394
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          406..441
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          672..722
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          729..776
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          785..832
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     CDS             1..961
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /coded_by="XM_054369531.1:71..2956"
                     /db_xref="GeneID:57758"
                     /db_xref="HGNC:HGNC:30425"
                     /db_xref="MIM:611747"
ORIGIN      
        1 mgvagrnrpg aawavlllll lppplllaga vppgrgraag pqedvdecaq glddchadal
       61 cqntptsykc sckpgyqgeg rqcedidecg nelnggcvhd clnipgnyrc tcfdgfmlah
      121 dghncldvde clennggcqh tcvnvmgsye ccckegffls dnqhtcihrs eeglscmnkd
      181 hgcshickea prgsvacecr pgfelaknqr dciltcnhgn ggcqhscddt adgpecschp
      241 qykmhtdgrs cleredtvle vtesnttsvv dgdkrvkrrl lmetcavnng gcdrtckdts
      301 tgvhcscpvg ftlqldgktc kdidecqtrn ggcdhfckni vgsfdcgckk gfklltdeks
      361 cqdvdecsld rtcdhscinh pgtfacacnr gytlygfthc gdtnecsinn ggcqqvcvnt
      421 vgsyecqchp gyklhwnkkd cvevkgllpt svsprvslhc gksgggdgcf lrchsgihls
      481 sglqgaysvt cgsssplrnk qqksndsafg dvttirtsvt fklnegkcsl knaelfpegl
      541 rpalpekhss vkesfryvnl tcssgkqvpg apgrpstpke mfitvefele tnqkevtasc
      601 dlscivkrte krlrkairtl rkavhreqfh lqlsgmnldv akkpprtser qaescgvgqg
      661 haenqcvscr agtyydgare rcilcpngtf qneegqmtce pcprpgnsga lktpeawnms
      721 ecgglcqpge ysadgfapcq lcalgtfqpe agrtscfpcg gglatkhqga tsfqdcetrv
      781 qcspghfynt tthrcircpv gtyqpefgkn ncvscpgntt tdfdgstnit qcktssnsvt
      841 tyetcqtyer piaftsrskk lwiqfksneg nsargfqvpy vtydedyqel iedivrdgrl
      901 yasenhqeil kdkklikalf dvlahpqnyf kytaqesrem fprsfirllr skvsrflrpy
      961 k
//
LOCUS       XP_054225507             959 aa            linear   PRI 05-AUG-2025
DEFINITION  signal peptide, CUB and EGF-like domain-containing protein 2
            isoform X3 [Homo sapiens].
ACCESSION   XP_054225507
VERSION     XP_054225507.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369532.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..959
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..959
                     /product="signal peptide, CUB and EGF-like
                     domain-containing protein 2 isoform X3"
                     /calculated_mol_wt=105736
     Region          48..83
                     /region_name="EGF_3"
                     /note="EGF domain; pfam12947"
                     /db_xref="CDD:463759"
     Region          94..125
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          131..166
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          176..212
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          216..251
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          285..320
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          <311..360
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          <358..394
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          406..441
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          604..654
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          661..708
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          717..764
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          769..880
                     /region_name="CUB"
                     /note="CUB domain; extracellular domain; present in
                     proteins mostly known to be involved in development; not
                     found in prokaryotes, plants and yeast; cd00041"
                     /db_xref="CDD:238001"
     Site            order(777,779,781,808,813,851,875,877,879..880)
                     /site_type="other"
                     /note="heterodimerization interface [polypeptide binding]"
                     /db_xref="CDD:238001"
     CDS             1..959
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /coded_by="XM_054369532.1:71..2950"
                     /db_xref="GeneID:57758"
                     /db_xref="HGNC:HGNC:30425"
                     /db_xref="MIM:611747"
ORIGIN      
        1 mgvagrnrpg aawavlllll lppplllaga vppgrgraag pqedvdecaq glddchadal
       61 cqntptsykc sckpgyqgeg rqcedidecg nelnggcvhd clnipgnyrc tcfdgfmlah
      121 dghncldvde clennggcqh tcvnvmgsye ccckegffls dnqhtcihrs eeglscmnkd
      181 hgcshickea prgsvacecr pgfelaknqr dciltcnhgn ggcqhscddt adgpecschp
      241 qykmhtdgrs cleredtvle vtesnttsvv dgdkrvkrrl lmetcavnng gcdrtckdts
      301 tgvhcscpvg ftlqldgktc kdidecqtrn ggcdhfckni vgsfdcgckk gfklltdeks
      361 cqdvdecsld rtcdhscinh pgtfacacnr gytlygfthc gdtnecsinn ggcqqvcvnt
      421 vgsyecqchp gyklhwnkkd cvdvttirts vtfklnegkc slknaelfpe glrpalpekh
      481 ssvkesfryv nltcssgkqv pgapgrpstp kemfitvefe letnqkevta scdlscivkr
      541 tekrlrkair tlrkavhreq fhlqlsgmnl dvakkpprts erqaescgvg qghaenqcvs
      601 cragtyydga rercilcpng tfqneegqmt cepcprpgns galktpeawn msecgglcqp
      661 geysadgfap cqlcalgtfq peagrtscfp cggglatkhq gatsfqdcet rvqcspghfy
      721 nttthrcirc pvgtyqpefg knncvscpgn tttdfdgstn itqcknrrcg gelgdftgyi
      781 espnypgnyp antectwtin pppkrriliv vpeiflpied dcgdylvmrk tsssnsvtty
      841 etcqtyerpi aftsrskklw iqfksnegns argfqvpyvt ydedyqelie divrdgrlya
      901 senhqeilkd kklikalfdv lahpqnyfky taqesremfp rsfirllrsk vsrflrpyk
//
LOCUS       XP_054225508             957 aa            linear   PRI 05-AUG-2025
DEFINITION  signal peptide, CUB and EGF-like domain-containing protein 2
            isoform X4 [Homo sapiens].
ACCESSION   XP_054225508
VERSION     XP_054225508.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369533.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..957
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..957
                     /product="signal peptide, CUB and EGF-like
                     domain-containing protein 2 isoform X4"
                     /calculated_mol_wt=105139
     Region          48..83
                     /region_name="EGF_3"
                     /note="EGF domain; pfam12947"
                     /db_xref="CDD:463759"
     Region          94..125
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          131..166
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          176..212
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          216..251
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          285..320
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          <311..360
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          <358..394
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          602..652
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          659..706
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          715..762
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          767..878
                     /region_name="CUB"
                     /note="CUB domain; extracellular domain; present in
                     proteins mostly known to be involved in development; not
                     found in prokaryotes, plants and yeast; cd00041"
                     /db_xref="CDD:238001"
     Site            order(775,777,779,806,811,849,873,875,877..878)
                     /site_type="other"
                     /note="heterodimerization interface [polypeptide binding]"
                     /db_xref="CDD:238001"
     CDS             1..957
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /coded_by="XM_054369533.1:71..2944"
                     /db_xref="GeneID:57758"
                     /db_xref="HGNC:HGNC:30425"
                     /db_xref="MIM:611747"
ORIGIN      
        1 mgvagrnrpg aawavlllll lppplllaga vppgrgraag pqedvdecaq glddchadal
       61 cqntptsykc sckpgyqgeg rqcedidecg nelnggcvhd clnipgnyrc tcfdgfmlah
      121 dghncldvde clennggcqh tcvnvmgsye ccckegffls dnqhtcihrs eeglscmnkd
      181 hgcshickea prgsvacecr pgfelaknqr dciltcnhgn ggcqhscddt adgpecschp
      241 qykmhtdgrs cleredtvle vtesnttsvv dgdkrvkrrl lmetcavnng gcdrtckdts
      301 tgvhcscpvg ftlqldgktc kdidecqtrn ggcdhfckni vgsfdcgckk gfklltdeks
      361 cqdvdecsld rtcdhscinh pgtfacacnr gytlygfthc gevkgllpts vsprvslhcg
      421 ksgggdgcfl rchsgihlss dvttirtsvt fklnegkcsl knaelfpegl rpalpekhss
      481 vkesfryvnl tcssgkqvpg apgrpstpke mfitvefele tnqkevtasc dlscivkrte
      541 krlrkairtl rkavhreqfh lqlsgmnldv akkpprtser qaescgvgqg haenqcvscr
      601 agtyydgare rcilcpngtf qneegqmtce pcprpgnsga lktpeawnms ecgglcqpge
      661 ysadgfapcq lcalgtfqpe agrtscfpcg gglatkhqga tsfqdcetrv qcspghfynt
      721 tthrcircpv gtyqpefgkn ncvscpgntt tdfdgstnit qcknrrcgge lgdftgyies
      781 pnypgnypan tectwtinpp pkrrilivvp eiflpieddc gdylvmrkts ssnsvttyet
      841 cqtyerpiaf tsrskklwiq fksnegnsar gfqvpyvtyd edyqeliedi vrdgrlyase
      901 nhqeilkdkk likalfdvla hpqnyfkyta qesremfprs firllrskvs rflrpyk
//
LOCUS       XP_054225509             952 aa            linear   PRI 05-AUG-2025
DEFINITION  signal peptide, CUB and EGF-like domain-containing protein 2
            isoform X5 [Homo sapiens].
ACCESSION   XP_054225509
VERSION     XP_054225509.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369534.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..952
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..952
                     /product="signal peptide, CUB and EGF-like
                     domain-containing protein 2 isoform X5"
                     /calculated_mol_wt=103479
     Region          48..83
                     /region_name="EGF_3"
                     /note="EGF domain; pfam12947"
                     /db_xref="CDD:463759"
     Region          94..125
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          131..166
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          176..212
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          216..251
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          285..320
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          <311..360
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          <358..394
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          406..441
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          672..722
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          729..776
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          785..832
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          837..948
                     /region_name="CUB"
                     /note="CUB domain; extracellular domain; present in
                     proteins mostly known to be involved in development; not
                     found in prokaryotes, plants and yeast; cd00041"
                     /db_xref="CDD:238001"
     Site            order(845,847,849,876,881,919,943,945,947..948)
                     /site_type="other"
                     /note="heterodimerization interface [polypeptide binding]"
                     /db_xref="CDD:238001"
     CDS             1..952
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /coded_by="XM_054369534.1:71..2929"
                     /db_xref="GeneID:57758"
                     /db_xref="HGNC:HGNC:30425"
                     /db_xref="MIM:611747"
ORIGIN      
        1 mgvagrnrpg aawavlllll lppplllaga vppgrgraag pqedvdecaq glddchadal
       61 cqntptsykc sckpgyqgeg rqcedidecg nelnggcvhd clnipgnyrc tcfdgfmlah
      121 dghncldvde clennggcqh tcvnvmgsye ccckegffls dnqhtcihrs eeglscmnkd
      181 hgcshickea prgsvacecr pgfelaknqr dciltcnhgn ggcqhscddt adgpecschp
      241 qykmhtdgrs cleredtvle vtesnttsvv dgdkrvkrrl lmetcavnng gcdrtckdts
      301 tgvhcscpvg ftlqldgktc kdidecqtrn ggcdhfckni vgsfdcgckk gfklltdeks
      361 cqdvdecsld rtcdhscinh pgtfacacnr gytlygfthc gdtnecsinn ggcqqvcvnt
      421 vgsyecqchp gyklhwnkkd cvevkgllpt svsprvslhc gksgggdgcf lrchsgihls
      481 sglqgaysvt cgsssplrnk qqksndsafg dvttirtsvt fklnegkcsl knaelfpegl
      541 rpalpekhss vkesfryvnl tcssgkqvpg apgrpstpke mfitvefele tnqkevtasc
      601 dlscivkrte krlrkairtl rkavhreqfh lqlsgmnldv akkpprtser qaescgvgqg
      661 haenqcvscr agtyydgare rcilcpngtf qneegqmtce pcprpgnsga lktpeawnms
      721 ecgglcqpge ysadgfapcq lcalgtfqpe agrtscfpcg gglatkhqga tsfqdcetrv
      781 qcspghfynt tthrcircpv gtyqpefgkn ncvscpgntt tdfdgstnit qcknrrcgge
      841 lgdftgyies pnypgnypan tectwtinpp pkrrilivvp eiflpieddc gdylvmrkts
      901 ssnsvttyet cqtyerpiaf tsrskklwiq fksnegnsar gfqvpyvtyd da
//
LOCUS       XP_054225510             941 aa            linear   PRI 05-AUG-2025
DEFINITION  signal peptide, CUB and EGF-like domain-containing protein 2
            isoform X6 [Homo sapiens].
ACCESSION   XP_054225510
VERSION     XP_054225510.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369535.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..941
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..941
                     /product="signal peptide, CUB and EGF-like
                     domain-containing protein 2 isoform X6"
                     /calculated_mol_wt=103527
     Region          48..83
                     /region_name="EGF_3"
                     /note="EGF domain; pfam12947"
                     /db_xref="CDD:463759"
     Region          94..125
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          131..166
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          176..212
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          216..251
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          285..320
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          <311..360
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          <358..394
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          406..441
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          643..690
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          699..746
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          751..862
                     /region_name="CUB"
                     /note="CUB domain; extracellular domain; present in
                     proteins mostly known to be involved in development; not
                     found in prokaryotes, plants and yeast; cd00041"
                     /db_xref="CDD:238001"
     Site            order(759,761,763,790,795,833,857,859,861..862)
                     /site_type="other"
                     /note="heterodimerization interface [polypeptide binding]"
                     /db_xref="CDD:238001"
     CDS             1..941
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /coded_by="XM_054369535.1:71..2896"
                     /db_xref="GeneID:57758"
                     /db_xref="HGNC:HGNC:30425"
                     /db_xref="MIM:611747"
ORIGIN      
        1 mgvagrnrpg aawavlllll lppplllaga vppgrgraag pqedvdecaq glddchadal
       61 cqntptsykc sckpgyqgeg rqcedidecg nelnggcvhd clnipgnyrc tcfdgfmlah
      121 dghncldvde clennggcqh tcvnvmgsye ccckegffls dnqhtcihrs eeglscmnkd
      181 hgcshickea prgsvacecr pgfelaknqr dciltcnhgn ggcqhscddt adgpecschp
      241 qykmhtdgrs cleredtvle vtesnttsvv dgdkrvkrrl lmetcavnng gcdrtckdts
      301 tgvhcscpvg ftlqldgktc kdidecqtrn ggcdhfckni vgsfdcgckk gfklltdeks
      361 cqdvdecsld rtcdhscinh pgtfacacnr gytlygfthc gdtnecsinn ggcqqvcvnt
      421 vgsyecqchp gyklhwnkkd cvevkgllpt svsprvslhc gksgggdgcf lrchsgihls
      481 sdvttirtsv tfklnegkcs lknaelfpeg lrpalpekhs svkesfryvn ltcssgkqvp
      541 gapgrpstpk emfitvefel etnqkevtas cdlscivkrt ekrlrkairt lrkavhreqf
      601 hlqlsgmnld vakkpprtse rqaescgvgq ghaenqcglc qpgeysadgf apcqlcalgt
      661 fqpeagrtsc fpcggglatk hqgatsfqdc etrvqcspgh fynttthrci rcpvgtyqpe
      721 fgknncvscp gntttdfdgs tnitqcknrr cggelgdftg yiespnypgn ypantectwt
      781 inpppkrril ivvpeiflpi eddcgdylvm rktsssnsvt tyetcqtyer piaftsrskk
      841 lwiqfksneg nsargfqvpy vtydedyqel iedivrdgrl yasenhqeil kdkklikalf
      901 dvlahpqnyf kytaqesrem fprsfirllr skvsrflrpy k
//
LOCUS       XP_054225511             932 aa            linear   PRI 05-AUG-2025
DEFINITION  signal peptide, CUB and EGF-like domain-containing protein 2
            isoform X7 [Homo sapiens].
ACCESSION   XP_054225511
VERSION     XP_054225511.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369536.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..932
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..932
                     /product="signal peptide, CUB and EGF-like
                     domain-containing protein 2 isoform X7"
                     /calculated_mol_wt=102212
     Region          48..83
                     /region_name="EGF_3"
                     /note="EGF domain; pfam12947"
                     /db_xref="CDD:463759"
     Region          94..125
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          131..166
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          176..212
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          216..251
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          285..320
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          <311..360
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          <358..394
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          406..441
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          643..693
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          700..747
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          756..803
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     CDS             1..932
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /coded_by="XM_054369536.1:71..2869"
                     /db_xref="GeneID:57758"
                     /db_xref="HGNC:HGNC:30425"
                     /db_xref="MIM:611747"
ORIGIN      
        1 mgvagrnrpg aawavlllll lppplllaga vppgrgraag pqedvdecaq glddchadal
       61 cqntptsykc sckpgyqgeg rqcedidecg nelnggcvhd clnipgnyrc tcfdgfmlah
      121 dghncldvde clennggcqh tcvnvmgsye ccckegffls dnqhtcihrs eeglscmnkd
      181 hgcshickea prgsvacecr pgfelaknqr dciltcnhgn ggcqhscddt adgpecschp
      241 qykmhtdgrs cleredtvle vtesnttsvv dgdkrvkrrl lmetcavnng gcdrtckdts
      301 tgvhcscpvg ftlqldgktc kdidecqtrn ggcdhfckni vgsfdcgckk gfklltdeks
      361 cqdvdecsld rtcdhscinh pgtfacacnr gytlygfthc gdtnecsinn ggcqqvcvnt
      421 vgsyecqchp gyklhwnkkd cvevkgllpt svsprvslhc gksgggdgcf lrchsgihls
      481 sdvttirtsv tfklnegkcs lknaelfpeg lrpalpekhs svkesfryvn ltcssgkqvp
      541 gapgrpstpk emfitvefel etnqkevtas cdlscivkrt ekrlrkairt lrkavhreqf
      601 hlqlsgmnld vakkpprtse rqaescgvgq ghaenqcvsc ragtyydgar ercilcpngt
      661 fqneegqmtc epcprpgnsg alktpeawnm secgglcqpg eysadgfapc qlcalgtfqp
      721 eagrtscfpc ggglatkhqg atsfqdcetr vqcspghfyn ttthrcircp vgtyqpefgk
      781 nncvscpgnt ttdfdgstni tqcktssnsv ttyetcqtye rpiaftsrsk klwiqfksne
      841 gnsargfqvp yvtydedyqe liedivrdgr lyasenhqei lkdkklikal fdvlahpqny
      901 fkytaqesre mfprsfirll rskvsrflrp yk
//
LOCUS       XP_054225512             923 aa            linear   PRI 05-AUG-2025
DEFINITION  signal peptide, CUB and EGF-like domain-containing protein 2
            isoform X8 [Homo sapiens].
ACCESSION   XP_054225512
VERSION     XP_054225512.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369537.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..923
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..923
                     /product="signal peptide, CUB and EGF-like
                     domain-containing protein 2 isoform X8"
                     /calculated_mol_wt=100508
     Region          48..83
                     /region_name="EGF_3"
                     /note="EGF domain; pfam12947"
                     /db_xref="CDD:463759"
     Region          94..125
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          131..166
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          176..212
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          216..251
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          285..320
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          <311..360
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          <358..394
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          406..441
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          643..693
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          700..747
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          756..803
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          808..919
                     /region_name="CUB"
                     /note="CUB domain; extracellular domain; present in
                     proteins mostly known to be involved in development; not
                     found in prokaryotes, plants and yeast; cd00041"
                     /db_xref="CDD:238001"
     Site            order(816,818,820,847,852,890,914,916,918..919)
                     /site_type="other"
                     /note="heterodimerization interface [polypeptide binding]"
                     /db_xref="CDD:238001"
     CDS             1..923
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /coded_by="XM_054369537.1:71..2842"
                     /db_xref="GeneID:57758"
                     /db_xref="HGNC:HGNC:30425"
                     /db_xref="MIM:611747"
ORIGIN      
        1 mgvagrnrpg aawavlllll lppplllaga vppgrgraag pqedvdecaq glddchadal
       61 cqntptsykc sckpgyqgeg rqcedidecg nelnggcvhd clnipgnyrc tcfdgfmlah
      121 dghncldvde clennggcqh tcvnvmgsye ccckegffls dnqhtcihrs eeglscmnkd
      181 hgcshickea prgsvacecr pgfelaknqr dciltcnhgn ggcqhscddt adgpecschp
      241 qykmhtdgrs cleredtvle vtesnttsvv dgdkrvkrrl lmetcavnng gcdrtckdts
      301 tgvhcscpvg ftlqldgktc kdidecqtrn ggcdhfckni vgsfdcgckk gfklltdeks
      361 cqdvdecsld rtcdhscinh pgtfacacnr gytlygfthc gdtnecsinn ggcqqvcvnt
      421 vgsyecqchp gyklhwnkkd cvevkgllpt svsprvslhc gksgggdgcf lrchsgihls
      481 sdvttirtsv tfklnegkcs lknaelfpeg lrpalpekhs svkesfryvn ltcssgkqvp
      541 gapgrpstpk emfitvefel etnqkevtas cdlscivkrt ekrlrkairt lrkavhreqf
      601 hlqlsgmnld vakkpprtse rqaescgvgq ghaenqcvsc ragtyydgar ercilcpngt
      661 fqneegqmtc epcprpgnsg alktpeawnm secgglcqpg eysadgfapc qlcalgtfqp
      721 eagrtscfpc ggglatkhqg atsfqdcetr vqcspghfyn ttthrcircp vgtyqpefgk
      781 nncvscpgnt ttdfdgstni tqcknrrcgg elgdftgyie spnypgnypa ntectwtinp
      841 ppkrrilivv peiflpiedd cgdylvmrkt sssnsvttye tcqtyerpia ftsrskklwi
      901 qfksnegnsa rgfqvpyvty dda
//
LOCUS       XP_054225513             920 aa            linear   PRI 05-AUG-2025
DEFINITION  signal peptide, CUB and EGF-like domain-containing protein 2
            isoform X9 [Homo sapiens].
ACCESSION   XP_054225513
VERSION     XP_054225513.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369538.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..920
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..920
                     /product="signal peptide, CUB and EGF-like
                     domain-containing protein 2 isoform X9"
                     /calculated_mol_wt=100624
     Region          48..83
                     /region_name="EGF_3"
                     /note="EGF domain; pfam12947"
                     /db_xref="CDD:463759"
     Region          94..125
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          131..166
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          176..212
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          216..251
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          285..320
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          <311..360
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          <358..394
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          631..681
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          688..735
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          744..791
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     CDS             1..920
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /coded_by="XM_054369538.1:71..2833"
                     /db_xref="GeneID:57758"
                     /db_xref="HGNC:HGNC:30425"
                     /db_xref="MIM:611747"
ORIGIN      
        1 mgvagrnrpg aawavlllll lppplllaga vppgrgraag pqedvdecaq glddchadal
       61 cqntptsykc sckpgyqgeg rqcedidecg nelnggcvhd clnipgnyrc tcfdgfmlah
      121 dghncldvde clennggcqh tcvnvmgsye ccckegffls dnqhtcihrs eeglscmnkd
      181 hgcshickea prgsvacecr pgfelaknqr dciltcnhgn ggcqhscddt adgpecschp
      241 qykmhtdgrs cleredtvle vtesnttsvv dgdkrvkrrl lmetcavnng gcdrtckdts
      301 tgvhcscpvg ftlqldgktc kdidecqtrn ggcdhfckni vgsfdcgckk gfklltdeks
      361 cqdvdecsld rtcdhscinh pgtfacacnr gytlygfthc gevkgllpts vsprvslhcg
      421 ksgggdgcfl rchsgihlss glqgaysvtc gsssplrnkq qksndsafgd vttirtsvtf
      481 klnegkcslk naelfpeglr palpekhssv kesfryvnlt cssgkqvpga pgrpstpkem
      541 fitvefelet nqkevtascd lscivkrtek rlrkairtlr kavhreqfhl qlsgmnldva
      601 kkpprtserq aescgvgqgh aenqcvscra gtyydgarer cilcpngtfq neegqmtcep
      661 cprpgnsgal ktpeawnmse cgglcqpgey sadgfapcql calgtfqpea grtscfpcgg
      721 glatkhqgat sfqdcetrvq cspghfyntt thrcircpvg tyqpefgknn cvscpgnttt
      781 dfdgstnitq cktssnsvtt yetcqtyerp iaftsrskkl wiqfksnegn sargfqvpyv
      841 tydedyqeli edivrdgrly asenhqeilk dkklikalfd vlahpqnyfk ytaqesremf
      901 prsfirllrs kvsrflrpyk
//
LOCUS       XP_054225514             918 aa            linear   PRI 05-AUG-2025
DEFINITION  signal peptide, CUB and EGF-like domain-containing protein 2
            isoform X10 [Homo sapiens].
ACCESSION   XP_054225514
VERSION     XP_054225514.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369539.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..918
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..918
                     /product="signal peptide, CUB and EGF-like
                     domain-containing protein 2 isoform X10"
                     /calculated_mol_wt=101177
     Region          48..83
                     /region_name="EGF_3"
                     /note="EGF domain; pfam12947"
                     /db_xref="CDD:463759"
     Region          94..125
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          131..166
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          176..212
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          216..251
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          285..320
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          <311..360
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          <358..394
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          563..613
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          620..667
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          676..723
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          728..839
                     /region_name="CUB"
                     /note="CUB domain; extracellular domain; present in
                     proteins mostly known to be involved in development; not
                     found in prokaryotes, plants and yeast; cd00041"
                     /db_xref="CDD:238001"
     Site            order(736,738,740,767,772,810,834,836,838..839)
                     /site_type="other"
                     /note="heterodimerization interface [polypeptide binding]"
                     /db_xref="CDD:238001"
     CDS             1..918
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /coded_by="XM_054369539.1:71..2827"
                     /db_xref="GeneID:57758"
                     /db_xref="HGNC:HGNC:30425"
                     /db_xref="MIM:611747"
ORIGIN      
        1 mgvagrnrpg aawavlllll lppplllaga vppgrgraag pqedvdecaq glddchadal
       61 cqntptsykc sckpgyqgeg rqcedidecg nelnggcvhd clnipgnyrc tcfdgfmlah
      121 dghncldvde clennggcqh tcvnvmgsye ccckegffls dnqhtcihrs eeglscmnkd
      181 hgcshickea prgsvacecr pgfelaknqr dciltcnhgn ggcqhscddt adgpecschp
      241 qykmhtdgrs cleredtvle vtesnttsvv dgdkrvkrrl lmetcavnng gcdrtckdts
      301 tgvhcscpvg ftlqldgktc kdidecqtrn ggcdhfckni vgsfdcgckk gfklltdeks
      361 cqdvdecsld rtcdhscinh pgtfacacnr gytlygfthc gdvttirtsv tfklnegkcs
      421 lknaelfpeg lrpalpekhs svkesfryvn ltcssgkqvp gapgrpstpk emfitvefel
      481 etnqkevtas cdlscivkrt ekrlrkairt lrkavhreqf hlqlsgmnld vakkpprtse
      541 rqaescgvgq ghaenqcvsc ragtyydgar ercilcpngt fqneegqmtc epcprpgnsg
      601 alktpeawnm secgglcqpg eysadgfapc qlcalgtfqp eagrtscfpc ggglatkhqg
      661 atsfqdcetr vqcspghfyn ttthrcircp vgtyqpefgk nncvscpgnt ttdfdgstni
      721 tqcknrrcgg elgdftgyie spnypgnypa ntectwtinp ppkrrilivv peiflpiedd
      781 cgdylvmrkt sssnsvttye tcqtyerpia ftsrskklwi qfksnegnsa rgfqvpyvty
      841 dedyqelied ivrdgrlyas enhqeilkdk klikalfdvl ahpqnyfkyt aqesremfpr
      901 sfirllrskv srflrpyk
//
LOCUS       XP_054225515             911 aa            linear   PRI 05-AUG-2025
DEFINITION  signal peptide, CUB and EGF-like domain-containing protein 2
            isoform X11 [Homo sapiens].
ACCESSION   XP_054225515
VERSION     XP_054225515.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369540.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..911
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..911
                     /product="signal peptide, CUB and EGF-like
                     domain-containing protein 2 isoform X11"
                     /calculated_mol_wt=98921
     Region          48..83
                     /region_name="EGF_3"
                     /note="EGF domain; pfam12947"
                     /db_xref="CDD:463759"
     Region          94..125
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          131..166
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          176..212
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          216..251
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          285..320
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          <311..360
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          <358..394
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          631..681
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          688..735
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          744..791
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          796..907
                     /region_name="CUB"
                     /note="CUB domain; extracellular domain; present in
                     proteins mostly known to be involved in development; not
                     found in prokaryotes, plants and yeast; cd00041"
                     /db_xref="CDD:238001"
     Site            order(804,806,808,835,840,878,902,904,906..907)
                     /site_type="other"
                     /note="heterodimerization interface [polypeptide binding]"
                     /db_xref="CDD:238001"
     CDS             1..911
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /coded_by="XM_054369540.1:71..2806"
                     /db_xref="GeneID:57758"
                     /db_xref="HGNC:HGNC:30425"
                     /db_xref="MIM:611747"
ORIGIN      
        1 mgvagrnrpg aawavlllll lppplllaga vppgrgraag pqedvdecaq glddchadal
       61 cqntptsykc sckpgyqgeg rqcedidecg nelnggcvhd clnipgnyrc tcfdgfmlah
      121 dghncldvde clennggcqh tcvnvmgsye ccckegffls dnqhtcihrs eeglscmnkd
      181 hgcshickea prgsvacecr pgfelaknqr dciltcnhgn ggcqhscddt adgpecschp
      241 qykmhtdgrs cleredtvle vtesnttsvv dgdkrvkrrl lmetcavnng gcdrtckdts
      301 tgvhcscpvg ftlqldgktc kdidecqtrn ggcdhfckni vgsfdcgckk gfklltdeks
      361 cqdvdecsld rtcdhscinh pgtfacacnr gytlygfthc gevkgllpts vsprvslhcg
      421 ksgggdgcfl rchsgihlss glqgaysvtc gsssplrnkq qksndsafgd vttirtsvtf
      481 klnegkcslk naelfpeglr palpekhssv kesfryvnlt cssgkqvpga pgrpstpkem
      541 fitvefelet nqkevtascd lscivkrtek rlrkairtlr kavhreqfhl qlsgmnldva
      601 kkpprtserq aescgvgqgh aenqcvscra gtyydgarer cilcpngtfq neegqmtcep
      661 cprpgnsgal ktpeawnmse cgglcqpgey sadgfapcql calgtfqpea grtscfpcgg
      721 glatkhqgat sfqdcetrvq cspghfyntt thrcircpvg tyqpefgknn cvscpgnttt
      781 dfdgstnitq cknrrcggel gdftgyiesp nypgnypant ectwtinppp krrilivvpe
      841 iflpieddcg dylvmrktss snsvttyetc qtyerpiaft srskklwiqf ksnegnsarg
      901 fqvpyvtydd a
//
LOCUS       XP_054225516             902 aa            linear   PRI 05-AUG-2025
DEFINITION  signal peptide, CUB and EGF-like domain-containing protein 2
            isoform X12 [Homo sapiens].
ACCESSION   XP_054225516
VERSION     XP_054225516.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369541.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..902
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..902
                     /product="signal peptide, CUB and EGF-like
                     domain-containing protein 2 isoform X12"
                     /calculated_mol_wt=99566
     Region          48..83
                     /region_name="EGF_3"
                     /note="EGF domain; pfam12947"
                     /db_xref="CDD:463759"
     Region          94..125
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          131..166
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          176..212
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          216..251
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          285..320
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          <311..360
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          <358..394
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          406..441
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          604..651
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          660..707
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          712..823
                     /region_name="CUB"
                     /note="CUB domain; extracellular domain; present in
                     proteins mostly known to be involved in development; not
                     found in prokaryotes, plants and yeast; cd00041"
                     /db_xref="CDD:238001"
     Site            order(720,722,724,751,756,794,818,820,822..823)
                     /site_type="other"
                     /note="heterodimerization interface [polypeptide binding]"
                     /db_xref="CDD:238001"
     CDS             1..902
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /coded_by="XM_054369541.1:71..2779"
                     /db_xref="GeneID:57758"
                     /db_xref="HGNC:HGNC:30425"
                     /db_xref="MIM:611747"
ORIGIN      
        1 mgvagrnrpg aawavlllll lppplllaga vppgrgraag pqedvdecaq glddchadal
       61 cqntptsykc sckpgyqgeg rqcedidecg nelnggcvhd clnipgnyrc tcfdgfmlah
      121 dghncldvde clennggcqh tcvnvmgsye ccckegffls dnqhtcihrs eeglscmnkd
      181 hgcshickea prgsvacecr pgfelaknqr dciltcnhgn ggcqhscddt adgpecschp
      241 qykmhtdgrs cleredtvle vtesnttsvv dgdkrvkrrl lmetcavnng gcdrtckdts
      301 tgvhcscpvg ftlqldgktc kdidecqtrn ggcdhfckni vgsfdcgckk gfklltdeks
      361 cqdvdecsld rtcdhscinh pgtfacacnr gytlygfthc gdtnecsinn ggcqqvcvnt
      421 vgsyecqchp gyklhwnkkd cvdvttirts vtfklnegkc slknaelfpe glrpalpekh
      481 ssvkesfryv nltcssgkqv pgapgrpstp kemfitvefe letnqkevta scdlscivkr
      541 tekrlrkair tlrkavhreq fhlqlsgmnl dvakkpprts erqaescgvg qghaenqcgl
      601 cqpgeysadg fapcqlcalg tfqpeagrts cfpcggglat khqgatsfqd cetrvqcspg
      661 hfynttthrc ircpvgtyqp efgknncvsc pgntttdfdg stnitqcknr rcggelgdft
      721 gyiespnypg nypantectw tinpppkrri livvpeiflp ieddcgdylv mrktsssnsv
      781 ttyetcqtye rpiaftsrsk klwiqfksne gnsargfqvp yvtydedyqe liedivrdgr
      841 lyasenhqei lkdkklikal fdvlahpqny fkytaqesre mfprsfirll rskvsrflrp
      901 yk
//
LOCUS       XP_054225517             895 aa            linear   PRI 05-AUG-2025
DEFINITION  signal peptide, CUB and EGF-like domain-containing protein 2
            isoform X13 [Homo sapiens].
ACCESSION   XP_054225517
VERSION     XP_054225517.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369542.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..895
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..895
                     /product="signal peptide, CUB and EGF-like
                     domain-containing protein 2 isoform X13"
                     /calculated_mol_wt=97309
     Region          48..83
                     /region_name="EGF_3"
                     /note="EGF domain; pfam12947"
                     /db_xref="CDD:463759"
     Region          94..125
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          131..166
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          176..212
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          216..251
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          285..320
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          <311..360
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          <358..394
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          406..441
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          672..719
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          728..775
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          780..891
                     /region_name="CUB"
                     /note="CUB domain; extracellular domain; present in
                     proteins mostly known to be involved in development; not
                     found in prokaryotes, plants and yeast; cd00041"
                     /db_xref="CDD:238001"
     Site            order(788,790,792,819,824,862,886,888,890..891)
                     /site_type="other"
                     /note="heterodimerization interface [polypeptide binding]"
                     /db_xref="CDD:238001"
     CDS             1..895
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /coded_by="XM_054369542.1:71..2758"
                     /db_xref="GeneID:57758"
                     /db_xref="HGNC:HGNC:30425"
                     /db_xref="MIM:611747"
ORIGIN      
        1 mgvagrnrpg aawavlllll lppplllaga vppgrgraag pqedvdecaq glddchadal
       61 cqntptsykc sckpgyqgeg rqcedidecg nelnggcvhd clnipgnyrc tcfdgfmlah
      121 dghncldvde clennggcqh tcvnvmgsye ccckegffls dnqhtcihrs eeglscmnkd
      181 hgcshickea prgsvacecr pgfelaknqr dciltcnhgn ggcqhscddt adgpecschp
      241 qykmhtdgrs cleredtvle vtesnttsvv dgdkrvkrrl lmetcavnng gcdrtckdts
      301 tgvhcscpvg ftlqldgktc kdidecqtrn ggcdhfckni vgsfdcgckk gfklltdeks
      361 cqdvdecsld rtcdhscinh pgtfacacnr gytlygfthc gdtnecsinn ggcqqvcvnt
      421 vgsyecqchp gyklhwnkkd cvevkgllpt svsprvslhc gksgggdgcf lrchsgihls
      481 sglqgaysvt cgsssplrnk qqksndsafg dvttirtsvt fklnegkcsl knaelfpegl
      541 rpalpekhss vkesfryvnl tcssgkqvpg apgrpstpke mfitvefele tnqkevtasc
      601 dlscivkrte krlrkairtl rkavhreqfh lqlsgmnldv akkpprtser qaescgvgqg
      661 haenqcglcq pgeysadgfa pcqlcalgtf qpeagrtscf pcggglatkh qgatsfqdce
      721 trvqcspghf ynttthrcir cpvgtyqpef gknncvscpg ntttdfdgst nitqcknrrc
      781 ggelgdftgy iespnypgny pantectwti npppkrrili vvpeiflpie ddcgdylvmr
      841 ktsssnsvtt yetcqtyerp iaftsrskkl wiqfksnegn sargfqvpyv tydda
//
LOCUS       XP_054225518             893 aa            linear   PRI 05-AUG-2025
DEFINITION  signal peptide, CUB and EGF-like domain-containing protein 2
            isoform X14 [Homo sapiens].
ACCESSION   XP_054225518
VERSION     XP_054225518.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369543.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..893
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..893
                     /product="signal peptide, CUB and EGF-like
                     domain-containing protein 2 isoform X14"
                     /calculated_mol_wt=98250
     Region          48..83
                     /region_name="EGF_3"
                     /note="EGF domain; pfam12947"
                     /db_xref="CDD:463759"
     Region          94..125
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          131..166
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          176..212
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          216..251
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          285..320
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          <311..360
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          <358..394
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          406..441
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          604..654
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          661..708
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          717..764
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     CDS             1..893
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /coded_by="XM_054369543.1:71..2752"
                     /db_xref="GeneID:57758"
                     /db_xref="HGNC:HGNC:30425"
                     /db_xref="MIM:611747"
ORIGIN      
        1 mgvagrnrpg aawavlllll lppplllaga vppgrgraag pqedvdecaq glddchadal
       61 cqntptsykc sckpgyqgeg rqcedidecg nelnggcvhd clnipgnyrc tcfdgfmlah
      121 dghncldvde clennggcqh tcvnvmgsye ccckegffls dnqhtcihrs eeglscmnkd
      181 hgcshickea prgsvacecr pgfelaknqr dciltcnhgn ggcqhscddt adgpecschp
      241 qykmhtdgrs cleredtvle vtesnttsvv dgdkrvkrrl lmetcavnng gcdrtckdts
      301 tgvhcscpvg ftlqldgktc kdidecqtrn ggcdhfckni vgsfdcgckk gfklltdeks
      361 cqdvdecsld rtcdhscinh pgtfacacnr gytlygfthc gdtnecsinn ggcqqvcvnt
      421 vgsyecqchp gyklhwnkkd cvdvttirts vtfklnegkc slknaelfpe glrpalpekh
      481 ssvkesfryv nltcssgkqv pgapgrpstp kemfitvefe letnqkevta scdlscivkr
      541 tekrlrkair tlrkavhreq fhlqlsgmnl dvakkpprts erqaescgvg qghaenqcvs
      601 cragtyydga rercilcpng tfqneegqmt cepcprpgns galktpeawn msecgglcqp
      661 geysadgfap cqlcalgtfq peagrtscfp cggglatkhq gatsfqdcet rvqcspghfy
      721 nttthrcirc pvgtyqpefg knncvscpgn tttdfdgstn itqcktssns vttyetcqty
      781 erpiaftsrs kklwiqfksn egnsargfqv pyvtydedyq eliedivrdg rlyasenhqe
      841 ilkdkklika lfdvlahpqn yfkytaqesr emfprsfirl lrskvsrflr pyk
//
LOCUS       XP_054225519             891 aa            linear   PRI 05-AUG-2025
DEFINITION  signal peptide, CUB and EGF-like domain-containing protein 2
            isoform X15 [Homo sapiens].
ACCESSION   XP_054225519
VERSION     XP_054225519.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369544.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..891
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..891
                     /product="signal peptide, CUB and EGF-like
                     domain-containing protein 2 isoform X15"
                     /calculated_mol_wt=97653
     Region          48..83
                     /region_name="EGF_3"
                     /note="EGF domain; pfam12947"
                     /db_xref="CDD:463759"
     Region          94..125
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          131..166
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          176..212
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          216..251
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          285..320
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          <311..360
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          <358..394
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          602..652
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          659..706
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          715..762
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     CDS             1..891
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /coded_by="XM_054369544.1:71..2746"
                     /db_xref="GeneID:57758"
                     /db_xref="HGNC:HGNC:30425"
                     /db_xref="MIM:611747"
ORIGIN      
        1 mgvagrnrpg aawavlllll lppplllaga vppgrgraag pqedvdecaq glddchadal
       61 cqntptsykc sckpgyqgeg rqcedidecg nelnggcvhd clnipgnyrc tcfdgfmlah
      121 dghncldvde clennggcqh tcvnvmgsye ccckegffls dnqhtcihrs eeglscmnkd
      181 hgcshickea prgsvacecr pgfelaknqr dciltcnhgn ggcqhscddt adgpecschp
      241 qykmhtdgrs cleredtvle vtesnttsvv dgdkrvkrrl lmetcavnng gcdrtckdts
      301 tgvhcscpvg ftlqldgktc kdidecqtrn ggcdhfckni vgsfdcgckk gfklltdeks
      361 cqdvdecsld rtcdhscinh pgtfacacnr gytlygfthc gevkgllpts vsprvslhcg
      421 ksgggdgcfl rchsgihlss dvttirtsvt fklnegkcsl knaelfpegl rpalpekhss
      481 vkesfryvnl tcssgkqvpg apgrpstpke mfitvefele tnqkevtasc dlscivkrte
      541 krlrkairtl rkavhreqfh lqlsgmnldv akkpprtser qaescgvgqg haenqcvscr
      601 agtyydgare rcilcpngtf qneegqmtce pcprpgnsga lktpeawnms ecgglcqpge
      661 ysadgfapcq lcalgtfqpe agrtscfpcg gglatkhqga tsfqdcetrv qcspghfynt
      721 tthrcircpv gtyqpefgkn ncvscpgntt tdfdgstnit qcktssnsvt tyetcqtyer
      781 piaftsrskk lwiqfksneg nsargfqvpy vtydedyqel iedivrdgrl yasenhqeil
      841 kdkklikalf dvlahpqnyf kytaqesrem fprsfirllr skvsrflrpy k
//
LOCUS       XP_054225520             886 aa            linear   PRI 05-AUG-2025
DEFINITION  signal peptide, CUB and EGF-like domain-containing protein 2
            isoform X16 [Homo sapiens].
ACCESSION   XP_054225520
VERSION     XP_054225520.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369545.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..886
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..886
                     /product="signal peptide, CUB and EGF-like
                     domain-containing protein 2 isoform X16"
                     /calculated_mol_wt=95993
     Region          48..83
                     /region_name="EGF_3"
                     /note="EGF domain; pfam12947"
                     /db_xref="CDD:463759"
     Region          94..125
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          131..166
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          176..212
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          216..251
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          285..320
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          <311..360
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          <358..394
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          406..441
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          672..722
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          729..776
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          785..832
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     CDS             1..886
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /coded_by="XM_054369545.1:71..2731"
                     /db_xref="GeneID:57758"
                     /db_xref="HGNC:HGNC:30425"
                     /db_xref="MIM:611747"
ORIGIN      
        1 mgvagrnrpg aawavlllll lppplllaga vppgrgraag pqedvdecaq glddchadal
       61 cqntptsykc sckpgyqgeg rqcedidecg nelnggcvhd clnipgnyrc tcfdgfmlah
      121 dghncldvde clennggcqh tcvnvmgsye ccckegffls dnqhtcihrs eeglscmnkd
      181 hgcshickea prgsvacecr pgfelaknqr dciltcnhgn ggcqhscddt adgpecschp
      241 qykmhtdgrs cleredtvle vtesnttsvv dgdkrvkrrl lmetcavnng gcdrtckdts
      301 tgvhcscpvg ftlqldgktc kdidecqtrn ggcdhfckni vgsfdcgckk gfklltdeks
      361 cqdvdecsld rtcdhscinh pgtfacacnr gytlygfthc gdtnecsinn ggcqqvcvnt
      421 vgsyecqchp gyklhwnkkd cvevkgllpt svsprvslhc gksgggdgcf lrchsgihls
      481 sglqgaysvt cgsssplrnk qqksndsafg dvttirtsvt fklnegkcsl knaelfpegl
      541 rpalpekhss vkesfryvnl tcssgkqvpg apgrpstpke mfitvefele tnqkevtasc
      601 dlscivkrte krlrkairtl rkavhreqfh lqlsgmnldv akkpprtser qaescgvgqg
      661 haenqcvscr agtyydgare rcilcpngtf qneegqmtce pcprpgnsga lktpeawnms
      721 ecgglcqpge ysadgfapcq lcalgtfqpe agrtscfpcg gglatkhqga tsfqdcetrv
      781 qcspghfynt tthrcircpv gtyqpefgkn ncvscpgntt tdfdgstnit qcktssnsvt
      841 tyetcqtyer piaftsrskk lwiqfksneg nsargfqvpy vtydda
//
LOCUS       XP_054225521             884 aa            linear   PRI 05-AUG-2025
DEFINITION  signal peptide, CUB and EGF-like domain-containing protein 2
            isoform X17 [Homo sapiens].
ACCESSION   XP_054225521
VERSION     XP_054225521.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369546.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..884
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..884
                     /product="signal peptide, CUB and EGF-like
                     domain-containing protein 2 isoform X17"
                     /calculated_mol_wt=96547
     Region          48..83
                     /region_name="EGF_3"
                     /note="EGF domain; pfam12947"
                     /db_xref="CDD:463759"
     Region          94..125
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          131..166
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          176..212
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          216..251
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          285..320
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          <311..360
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          <358..394
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          406..441
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          604..654
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          661..708
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          717..764
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          769..880
                     /region_name="CUB"
                     /note="CUB domain; extracellular domain; present in
                     proteins mostly known to be involved in development; not
                     found in prokaryotes, plants and yeast; cd00041"
                     /db_xref="CDD:238001"
     Site            order(777,779,781,808,813,851,875,877,879..880)
                     /site_type="other"
                     /note="heterodimerization interface [polypeptide binding]"
                     /db_xref="CDD:238001"
     CDS             1..884
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /coded_by="XM_054369546.1:71..2725"
                     /db_xref="GeneID:57758"
                     /db_xref="HGNC:HGNC:30425"
                     /db_xref="MIM:611747"
ORIGIN      
        1 mgvagrnrpg aawavlllll lppplllaga vppgrgraag pqedvdecaq glddchadal
       61 cqntptsykc sckpgyqgeg rqcedidecg nelnggcvhd clnipgnyrc tcfdgfmlah
      121 dghncldvde clennggcqh tcvnvmgsye ccckegffls dnqhtcihrs eeglscmnkd
      181 hgcshickea prgsvacecr pgfelaknqr dciltcnhgn ggcqhscddt adgpecschp
      241 qykmhtdgrs cleredtvle vtesnttsvv dgdkrvkrrl lmetcavnng gcdrtckdts
      301 tgvhcscpvg ftlqldgktc kdidecqtrn ggcdhfckni vgsfdcgckk gfklltdeks
      361 cqdvdecsld rtcdhscinh pgtfacacnr gytlygfthc gdtnecsinn ggcqqvcvnt
      421 vgsyecqchp gyklhwnkkd cvdvttirts vtfklnegkc slknaelfpe glrpalpekh
      481 ssvkesfryv nltcssgkqv pgapgrpstp kemfitvefe letnqkevta scdlscivkr
      541 tekrlrkair tlrkavhreq fhlqlsgmnl dvakkpprts erqaescgvg qghaenqcvs
      601 cragtyydga rercilcpng tfqneegqmt cepcprpgns galktpeawn msecgglcqp
      661 geysadgfap cqlcalgtfq peagrtscfp cggglatkhq gatsfqdcet rvqcspghfy
      721 nttthrcirc pvgtyqpefg knncvscpgn tttdfdgstn itqcknrrcg gelgdftgyi
      781 espnypgnyp antectwtin pppkrriliv vpeiflpied dcgdylvmrk tsssnsvtty
      841 etcqtyerpi aftsrskklw iqfksnegns argfqvpyvt ydda
//
LOCUS       XP_054225522             872 aa            linear   PRI 05-AUG-2025
DEFINITION  signal peptide, CUB and EGF-like domain-containing protein 2
            isoform X18 [Homo sapiens].
ACCESSION   XP_054225522
VERSION     XP_054225522.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369547.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..872
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..872
                     /product="signal peptide, CUB and EGF-like
                     domain-containing protein 2 isoform X18"
                     /calculated_mol_wt=96096
     Region          48..83
                     /region_name="EGF_3"
                     /note="EGF domain; pfam12947"
                     /db_xref="CDD:463759"
     Region          94..125
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          131..166
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          176..212
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          216..251
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          285..320
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          <311..360
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          <358..394
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          406..441
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          517..567
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          574..621
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          630..677
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          682..793
                     /region_name="CUB"
                     /note="CUB domain; extracellular domain; present in
                     proteins mostly known to be involved in development; not
                     found in prokaryotes, plants and yeast; cd00041"
                     /db_xref="CDD:238001"
     Site            order(690,692,694,721,726,764,788,790,792..793)
                     /site_type="other"
                     /note="heterodimerization interface [polypeptide binding]"
                     /db_xref="CDD:238001"
     CDS             1..872
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /coded_by="XM_054369547.1:71..2689"
                     /db_xref="GeneID:57758"
                     /db_xref="HGNC:HGNC:30425"
                     /db_xref="MIM:611747"
ORIGIN      
        1 mgvagrnrpg aawavlllll lppplllaga vppgrgraag pqedvdecaq glddchadal
       61 cqntptsykc sckpgyqgeg rqcedidecg nelnggcvhd clnipgnyrc tcfdgfmlah
      121 dghncldvde clennggcqh tcvnvmgsye ccckegffls dnqhtcihrs eeglscmnkd
      181 hgcshickea prgsvacecr pgfelaknqr dciltcnhgn ggcqhscddt adgpecschp
      241 qykmhtdgrs cleredtvle vtesnttsvv dgdkrvkrrl lmetcavnng gcdrtckdts
      301 tgvhcscpvg ftlqldgktc kdidecqtrn ggcdhfckni vgsfdcgckk gfklltdeks
      361 cqdvdecsld rtcdhscinh pgtfacacnr gytlygfthc gdtnecsinn ggcqqvcvnt
      421 vgsyecqchp gyklhwnkkd cvascdlsci vkrtekrlrk airtlrkavh reqfhlqlsg
      481 mnldvakkpp rtserqaesc gvgqghaenq cvscragtyy dgarercilc pngtfqneeg
      541 qmtcepcprp gnsgalktpe awnmsecggl cqpgeysadg fapcqlcalg tfqpeagrts
      601 cfpcggglat khqgatsfqd cetrvqcspg hfynttthrc ircpvgtyqp efgknncvsc
      661 pgntttdfdg stnitqcknr rcggelgdft gyiespnypg nypantectw tinpppkrri
      721 livvpeiflp ieddcgdylv mrktsssnsv ttyetcqtye rpiaftsrsk klwiqfksne
      781 gnsargfqvp yvtydedyqe liedivrdgr lyasenhqei lkdkklikal fdvlahpqny
      841 fkytaqesre mfprsfirll rskvsrflrp yk
//
LOCUS       XP_054225523             861 aa            linear   PRI 05-AUG-2025
DEFINITION  signal peptide, CUB and EGF-like domain-containing protein 2
            isoform X19 [Homo sapiens].
ACCESSION   XP_054225523
VERSION     XP_054225523.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369548.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..861
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..861
                     /product="signal peptide, CUB and EGF-like
                     domain-containing protein 2 isoform X19"
                     /calculated_mol_wt=95008
     Region          48..83
                     /region_name="EGF_3"
                     /note="EGF domain; pfam12947"
                     /db_xref="CDD:463759"
     Region          94..125
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          131..166
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          176..212
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          216..251
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          285..320
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          <311..360
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          <358..394
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          563..610
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          619..666
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          671..782
                     /region_name="CUB"
                     /note="CUB domain; extracellular domain; present in
                     proteins mostly known to be involved in development; not
                     found in prokaryotes, plants and yeast; cd00041"
                     /db_xref="CDD:238001"
     Site            order(679,681,683,710,715,753,777,779,781..782)
                     /site_type="other"
                     /note="heterodimerization interface [polypeptide binding]"
                     /db_xref="CDD:238001"
     CDS             1..861
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /coded_by="XM_054369548.1:71..2656"
                     /db_xref="GeneID:57758"
                     /db_xref="HGNC:HGNC:30425"
                     /db_xref="MIM:611747"
ORIGIN      
        1 mgvagrnrpg aawavlllll lppplllaga vppgrgraag pqedvdecaq glddchadal
       61 cqntptsykc sckpgyqgeg rqcedidecg nelnggcvhd clnipgnyrc tcfdgfmlah
      121 dghncldvde clennggcqh tcvnvmgsye ccckegffls dnqhtcihrs eeglscmnkd
      181 hgcshickea prgsvacecr pgfelaknqr dciltcnhgn ggcqhscddt adgpecschp
      241 qykmhtdgrs cleredtvle vtesnttsvv dgdkrvkrrl lmetcavnng gcdrtckdts
      301 tgvhcscpvg ftlqldgktc kdidecqtrn ggcdhfckni vgsfdcgckk gfklltdeks
      361 cqdvdecsld rtcdhscinh pgtfacacnr gytlygfthc gdvttirtsv tfklnegkcs
      421 lknaelfpeg lrpalpekhs svkesfryvn ltcssgkqvp gapgrpstpk emfitvefel
      481 etnqkevtas cdlscivkrt ekrlrkairt lrkavhreqf hlqlsgmnld vakkpprtse
      541 rqaescgvgq ghaenqcglc qpgeysadgf apcqlcalgt fqpeagrtsc fpcggglatk
      601 hqgatsfqdc etrvqcspgh fynttthrci rcpvgtyqpe fgknncvscp gntttdfdgs
      661 tnitqcknrr cggelgdftg yiespnypgn ypantectwt inpppkrril ivvpeiflpi
      721 eddcgdylvm rktsssnsvt tyetcqtyer piaftsrskk lwiqfksneg nsargfqvpy
      781 vtydedyqel iedivrdgrl yasenhqeil kdkklikalf dvlahpqnyf kytaqesrem
      841 fprsfirllr skvsrflrpy k
//
LOCUS       XP_054225524             852 aa            linear   PRI 05-AUG-2025
DEFINITION  signal peptide, CUB and EGF-like domain-containing protein 2
            isoform X20 [Homo sapiens].
ACCESSION   XP_054225524
VERSION     XP_054225524.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369549.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..852
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..852
                     /product="signal peptide, CUB and EGF-like
                     domain-containing protein 2 isoform X20"
                     /calculated_mol_wt=93692
     Region          48..83
                     /region_name="EGF_3"
                     /note="EGF domain; pfam12947"
                     /db_xref="CDD:463759"
     Region          94..125
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          131..166
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          176..212
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          216..251
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          285..320
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          <311..360
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          <358..394
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          563..613
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          620..667
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          676..723
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     CDS             1..852
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /coded_by="XM_054369549.1:71..2629"
                     /db_xref="GeneID:57758"
                     /db_xref="HGNC:HGNC:30425"
                     /db_xref="MIM:611747"
ORIGIN      
        1 mgvagrnrpg aawavlllll lppplllaga vppgrgraag pqedvdecaq glddchadal
       61 cqntptsykc sckpgyqgeg rqcedidecg nelnggcvhd clnipgnyrc tcfdgfmlah
      121 dghncldvde clennggcqh tcvnvmgsye ccckegffls dnqhtcihrs eeglscmnkd
      181 hgcshickea prgsvacecr pgfelaknqr dciltcnhgn ggcqhscddt adgpecschp
      241 qykmhtdgrs cleredtvle vtesnttsvv dgdkrvkrrl lmetcavnng gcdrtckdts
      301 tgvhcscpvg ftlqldgktc kdidecqtrn ggcdhfckni vgsfdcgckk gfklltdeks
      361 cqdvdecsld rtcdhscinh pgtfacacnr gytlygfthc gdvttirtsv tfklnegkcs
      421 lknaelfpeg lrpalpekhs svkesfryvn ltcssgkqvp gapgrpstpk emfitvefel
      481 etnqkevtas cdlscivkrt ekrlrkairt lrkavhreqf hlqlsgmnld vakkpprtse
      541 rqaescgvgq ghaenqcvsc ragtyydgar ercilcpngt fqneegqmtc epcprpgnsg
      601 alktpeawnm secgglcqpg eysadgfapc qlcalgtfqp eagrtscfpc ggglatkhqg
      661 atsfqdcetr vqcspghfyn ttthrcircp vgtyqpefgk nncvscpgnt ttdfdgstni
      721 tqcktssnsv ttyetcqtye rpiaftsrsk klwiqfksne gnsargfqvp yvtydedyqe
      781 liedivrdgr lyasenhqei lkdkklikal fdvlahpqny fkytaqesre mfprsfirll
      841 rskvsrflrp yk
//
LOCUS       XP_054225525             843 aa            linear   PRI 05-AUG-2025
DEFINITION  signal peptide, CUB and EGF-like domain-containing protein 2
            isoform X21 [Homo sapiens].
ACCESSION   XP_054225525
VERSION     XP_054225525.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369550.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..843
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..843
                     /product="signal peptide, CUB and EGF-like
                     domain-containing protein 2 isoform X21"
                     /calculated_mol_wt=91989
     Region          48..83
                     /region_name="EGF_3"
                     /note="EGF domain; pfam12947"
                     /db_xref="CDD:463759"
     Region          94..125
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          131..166
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          176..212
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          216..251
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          285..320
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          <311..360
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          <358..394
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          563..613
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          620..667
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          676..723
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          728..839
                     /region_name="CUB"
                     /note="CUB domain; extracellular domain; present in
                     proteins mostly known to be involved in development; not
                     found in prokaryotes, plants and yeast; cd00041"
                     /db_xref="CDD:238001"
     Site            order(736,738,740,767,772,810,834,836,838..839)
                     /site_type="other"
                     /note="heterodimerization interface [polypeptide binding]"
                     /db_xref="CDD:238001"
     CDS             1..843
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /coded_by="XM_054369550.1:71..2602"
                     /db_xref="GeneID:57758"
                     /db_xref="HGNC:HGNC:30425"
                     /db_xref="MIM:611747"
ORIGIN      
        1 mgvagrnrpg aawavlllll lppplllaga vppgrgraag pqedvdecaq glddchadal
       61 cqntptsykc sckpgyqgeg rqcedidecg nelnggcvhd clnipgnyrc tcfdgfmlah
      121 dghncldvde clennggcqh tcvnvmgsye ccckegffls dnqhtcihrs eeglscmnkd
      181 hgcshickea prgsvacecr pgfelaknqr dciltcnhgn ggcqhscddt adgpecschp
      241 qykmhtdgrs cleredtvle vtesnttsvv dgdkrvkrrl lmetcavnng gcdrtckdts
      301 tgvhcscpvg ftlqldgktc kdidecqtrn ggcdhfckni vgsfdcgckk gfklltdeks
      361 cqdvdecsld rtcdhscinh pgtfacacnr gytlygfthc gdvttirtsv tfklnegkcs
      421 lknaelfpeg lrpalpekhs svkesfryvn ltcssgkqvp gapgrpstpk emfitvefel
      481 etnqkevtas cdlscivkrt ekrlrkairt lrkavhreqf hlqlsgmnld vakkpprtse
      541 rqaescgvgq ghaenqcvsc ragtyydgar ercilcpngt fqneegqmtc epcprpgnsg
      601 alktpeawnm secgglcqpg eysadgfapc qlcalgtfqp eagrtscfpc ggglatkhqg
      661 atsfqdcetr vqcspghfyn ttthrcircp vgtyqpefgk nncvscpgnt ttdfdgstni
      721 tqcknrrcgg elgdftgyie spnypgnypa ntectwtinp ppkrrilivv peiflpiedd
      781 cgdylvmrkt sssnsvttye tcqtyerpia ftsrskklwi qfksnegnsa rgfqvpyvty
      841 dda
//
LOCUS       XP_054225526             818 aa            linear   PRI 05-AUG-2025
DEFINITION  signal peptide, CUB and EGF-like domain-containing protein 2
            isoform X22 [Homo sapiens].
ACCESSION   XP_054225526
VERSION     XP_054225526.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369551.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..818
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..818
                     /product="signal peptide, CUB and EGF-like
                     domain-containing protein 2 isoform X22"
                     /calculated_mol_wt=89061
     Region          48..83
                     /region_name="EGF_3"
                     /note="EGF domain; pfam12947"
                     /db_xref="CDD:463759"
     Region          94..125
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          131..166
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          176..212
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          216..251
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          285..320
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          <311..360
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          <358..394
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          406..441
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          604..654
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          661..708
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          717..764
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     CDS             1..818
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /coded_by="XM_054369551.1:71..2527"
                     /db_xref="GeneID:57758"
                     /db_xref="HGNC:HGNC:30425"
                     /db_xref="MIM:611747"
ORIGIN      
        1 mgvagrnrpg aawavlllll lppplllaga vppgrgraag pqedvdecaq glddchadal
       61 cqntptsykc sckpgyqgeg rqcedidecg nelnggcvhd clnipgnyrc tcfdgfmlah
      121 dghncldvde clennggcqh tcvnvmgsye ccckegffls dnqhtcihrs eeglscmnkd
      181 hgcshickea prgsvacecr pgfelaknqr dciltcnhgn ggcqhscddt adgpecschp
      241 qykmhtdgrs cleredtvle vtesnttsvv dgdkrvkrrl lmetcavnng gcdrtckdts
      301 tgvhcscpvg ftlqldgktc kdidecqtrn ggcdhfckni vgsfdcgckk gfklltdeks
      361 cqdvdecsld rtcdhscinh pgtfacacnr gytlygfthc gdtnecsinn ggcqqvcvnt
      421 vgsyecqchp gyklhwnkkd cvdvttirts vtfklnegkc slknaelfpe glrpalpekh
      481 ssvkesfryv nltcssgkqv pgapgrpstp kemfitvefe letnqkevta scdlscivkr
      541 tekrlrkair tlrkavhreq fhlqlsgmnl dvakkpprts erqaescgvg qghaenqcvs
      601 cragtyydga rercilcpng tfqneegqmt cepcprpgns galktpeawn msecgglcqp
      661 geysadgfap cqlcalgtfq peagrtscfp cggglatkhq gatsfqdcet rvqcspghfy
      721 nttthrcirc pvgtyqpefg knncvscpgn tttdfdgstn itqcktssns vttyetcqty
      781 erpiaftsrs kklwiqfksn egnsargfqv pyvtydda
//
LOCUS       XP_054225527             815 aa            linear   PRI 05-AUG-2025
DEFINITION  signal peptide, CUB and EGF-like domain-containing protein 2
            isoform X23 [Homo sapiens].
ACCESSION   XP_054225527
VERSION     XP_054225527.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369552.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..815
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..815
                     /product="signal peptide, CUB and EGF-like
                     domain-containing protein 2 isoform X23"
                     /calculated_mol_wt=89926
     Region          48..83
                     /region_name="EGF_3"
                     /note="EGF domain; pfam12947"
                     /db_xref="CDD:463759"
     Region          94..125
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          131..166
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          176..212
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          216..251
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          285..320
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          <311..360
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          <358..394
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          406..441
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          517..564
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          573..620
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          625..736
                     /region_name="CUB"
                     /note="CUB domain; extracellular domain; present in
                     proteins mostly known to be involved in development; not
                     found in prokaryotes, plants and yeast; cd00041"
                     /db_xref="CDD:238001"
     Site            order(633,635,637,664,669,707,731,733,735..736)
                     /site_type="other"
                     /note="heterodimerization interface [polypeptide binding]"
                     /db_xref="CDD:238001"
     CDS             1..815
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /coded_by="XM_054369552.1:71..2518"
                     /db_xref="GeneID:57758"
                     /db_xref="HGNC:HGNC:30425"
                     /db_xref="MIM:611747"
ORIGIN      
        1 mgvagrnrpg aawavlllll lppplllaga vppgrgraag pqedvdecaq glddchadal
       61 cqntptsykc sckpgyqgeg rqcedidecg nelnggcvhd clnipgnyrc tcfdgfmlah
      121 dghncldvde clennggcqh tcvnvmgsye ccckegffls dnqhtcihrs eeglscmnkd
      181 hgcshickea prgsvacecr pgfelaknqr dciltcnhgn ggcqhscddt adgpecschp
      241 qykmhtdgrs cleredtvle vtesnttsvv dgdkrvkrrl lmetcavnng gcdrtckdts
      301 tgvhcscpvg ftlqldgktc kdidecqtrn ggcdhfckni vgsfdcgckk gfklltdeks
      361 cqdvdecsld rtcdhscinh pgtfacacnr gytlygfthc gdtnecsinn ggcqqvcvnt
      421 vgsyecqchp gyklhwnkkd cvascdlsci vkrtekrlrk airtlrkavh reqfhlqlsg
      481 mnldvakkpp rtserqaesc gvgqghaenq cglcqpgeys adgfapcqlc algtfqpeag
      541 rtscfpcggg latkhqgats fqdcetrvqc spghfynttt hrcircpvgt yqpefgknnc
      601 vscpgntttd fdgstnitqc knrrcggelg dftgyiespn ypgnypante ctwtinpppk
      661 rrilivvpei flpieddcgd ylvmrktsss nsvttyetcq tyerpiafts rskklwiqfk
      721 snegnsargf qvpyvtyded yqeliedivr dgrlyasenh qeilkdkkli kalfdvlahp
      781 qnyfkytaqe sremfprsfi rllrskvsrf lrpyk
//
LOCUS       XP_054225528             797 aa            linear   PRI 05-AUG-2025
DEFINITION  signal peptide, CUB and EGF-like domain-containing protein 2
            isoform X24 [Homo sapiens].
ACCESSION   XP_054225528
VERSION     XP_054225528.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369553.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..797
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..797
                     /product="signal peptide, CUB and EGF-like
                     domain-containing protein 2 isoform X24"
                     /calculated_mol_wt=86907
     Region          48..83
                     /region_name="EGF_3"
                     /note="EGF domain; pfam12947"
                     /db_xref="CDD:463759"
     Region          94..125
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          131..166
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          176..212
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          216..251
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          285..320
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          <311..360
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          <358..394
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          406..441
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          517..567
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          574..621
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          630..677
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          682..793
                     /region_name="CUB"
                     /note="CUB domain; extracellular domain; present in
                     proteins mostly known to be involved in development; not
                     found in prokaryotes, plants and yeast; cd00041"
                     /db_xref="CDD:238001"
     Site            order(690,692,694,721,726,764,788,790,792..793)
                     /site_type="other"
                     /note="heterodimerization interface [polypeptide binding]"
                     /db_xref="CDD:238001"
     CDS             1..797
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /coded_by="XM_054369553.1:71..2464"
                     /db_xref="GeneID:57758"
                     /db_xref="HGNC:HGNC:30425"
                     /db_xref="MIM:611747"
ORIGIN      
        1 mgvagrnrpg aawavlllll lppplllaga vppgrgraag pqedvdecaq glddchadal
       61 cqntptsykc sckpgyqgeg rqcedidecg nelnggcvhd clnipgnyrc tcfdgfmlah
      121 dghncldvde clennggcqh tcvnvmgsye ccckegffls dnqhtcihrs eeglscmnkd
      181 hgcshickea prgsvacecr pgfelaknqr dciltcnhgn ggcqhscddt adgpecschp
      241 qykmhtdgrs cleredtvle vtesnttsvv dgdkrvkrrl lmetcavnng gcdrtckdts
      301 tgvhcscpvg ftlqldgktc kdidecqtrn ggcdhfckni vgsfdcgckk gfklltdeks
      361 cqdvdecsld rtcdhscinh pgtfacacnr gytlygfthc gdtnecsinn ggcqqvcvnt
      421 vgsyecqchp gyklhwnkkd cvascdlsci vkrtekrlrk airtlrkavh reqfhlqlsg
      481 mnldvakkpp rtserqaesc gvgqghaenq cvscragtyy dgarercilc pngtfqneeg
      541 qmtcepcprp gnsgalktpe awnmsecggl cqpgeysadg fapcqlcalg tfqpeagrts
      601 cfpcggglat khqgatsfqd cetrvqcspg hfynttthrc ircpvgtyqp efgknncvsc
      661 pgntttdfdg stnitqcknr rcggelgdft gyiespnypg nypantectw tinpppkrri
      721 livvpeiflp ieddcgdylv mrktsssnsv ttyetcqtye rpiaftsrsk klwiqfksne
      781 gnsargfqvp yvtydda
//
LOCUS       XP_054225529             777 aa            linear   PRI 05-AUG-2025
DEFINITION  signal peptide, CUB and EGF-like domain-containing protein 2
            isoform X25 [Homo sapiens].
ACCESSION   XP_054225529
VERSION     XP_054225529.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369554.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..777
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..777
                     /product="signal peptide, CUB and EGF-like
                     domain-containing protein 2 isoform X25"
                     /calculated_mol_wt=84503
     Region          48..83
                     /region_name="EGF_3"
                     /note="EGF domain; pfam12947"
                     /db_xref="CDD:463759"
     Region          94..125
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          131..166
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          176..212
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          216..251
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          285..320
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          <311..360
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          <358..394
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          563..613
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          620..667
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          676..723
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     CDS             1..777
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /coded_by="XM_054369554.1:71..2404"
                     /db_xref="GeneID:57758"
                     /db_xref="HGNC:HGNC:30425"
                     /db_xref="MIM:611747"
ORIGIN      
        1 mgvagrnrpg aawavlllll lppplllaga vppgrgraag pqedvdecaq glddchadal
       61 cqntptsykc sckpgyqgeg rqcedidecg nelnggcvhd clnipgnyrc tcfdgfmlah
      121 dghncldvde clennggcqh tcvnvmgsye ccckegffls dnqhtcihrs eeglscmnkd
      181 hgcshickea prgsvacecr pgfelaknqr dciltcnhgn ggcqhscddt adgpecschp
      241 qykmhtdgrs cleredtvle vtesnttsvv dgdkrvkrrl lmetcavnng gcdrtckdts
      301 tgvhcscpvg ftlqldgktc kdidecqtrn ggcdhfckni vgsfdcgckk gfklltdeks
      361 cqdvdecsld rtcdhscinh pgtfacacnr gytlygfthc gdvttirtsv tfklnegkcs
      421 lknaelfpeg lrpalpekhs svkesfryvn ltcssgkqvp gapgrpstpk emfitvefel
      481 etnqkevtas cdlscivkrt ekrlrkairt lrkavhreqf hlqlsgmnld vakkpprtse
      541 rqaescgvgq ghaenqcvsc ragtyydgar ercilcpngt fqneegqmtc epcprpgnsg
      601 alktpeawnm secgglcqpg eysadgfapc qlcalgtfqp eagrtscfpc ggglatkhqg
      661 atsfqdcetr vqcspghfyn ttthrcircp vgtyqpefgk nncvscpgnt ttdfdgstni
      721 tqcktssnsv ttyetcqtye rpiaftsrsk klwiqfksne gnsargfqvp yvtydda
//
LOCUS       XP_054225530             731 aa            linear   PRI 05-AUG-2025
DEFINITION  signal peptide, CUB and EGF-like domain-containing protein 2
            isoform X26 [Homo sapiens].
ACCESSION   XP_054225530
VERSION     XP_054225530.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369555.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..731
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..731
                     /product="signal peptide, CUB and EGF-like
                     domain-containing protein 2 isoform X26"
                     /calculated_mol_wt=79421
     Region          48..83
                     /region_name="EGF_3"
                     /note="EGF domain; pfam12947"
                     /db_xref="CDD:463759"
     Region          94..125
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          131..166
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          176..212
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          216..251
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          285..320
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          <311..360
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          <358..394
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          406..441
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          517..567
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          574..621
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     Region          630..677
                     /region_name="Ephrin_rec_like"
                     /note="Tyrosine-protein kinase ephrin type A/B
                     receptor-like; pfam07699"
                     /db_xref="CDD:429604"
     CDS             1..731
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /coded_by="XM_054369555.1:71..2266"
                     /db_xref="GeneID:57758"
                     /db_xref="HGNC:HGNC:30425"
                     /db_xref="MIM:611747"
ORIGIN      
        1 mgvagrnrpg aawavlllll lppplllaga vppgrgraag pqedvdecaq glddchadal
       61 cqntptsykc sckpgyqgeg rqcedidecg nelnggcvhd clnipgnyrc tcfdgfmlah
      121 dghncldvde clennggcqh tcvnvmgsye ccckegffls dnqhtcihrs eeglscmnkd
      181 hgcshickea prgsvacecr pgfelaknqr dciltcnhgn ggcqhscddt adgpecschp
      241 qykmhtdgrs cleredtvle vtesnttsvv dgdkrvkrrl lmetcavnng gcdrtckdts
      301 tgvhcscpvg ftlqldgktc kdidecqtrn ggcdhfckni vgsfdcgckk gfklltdeks
      361 cqdvdecsld rtcdhscinh pgtfacacnr gytlygfthc gdtnecsinn ggcqqvcvnt
      421 vgsyecqchp gyklhwnkkd cvascdlsci vkrtekrlrk airtlrkavh reqfhlqlsg
      481 mnldvakkpp rtserqaesc gvgqghaenq cvscragtyy dgarercilc pngtfqneeg
      541 qmtcepcprp gnsgalktpe awnmsecggl cqpgeysadg fapcqlcalg tfqpeagrts
      601 cfpcggglat khqgatsfqd cetrvqcspg hfynttthrc ircpvgtyqp efgknncvsc
      661 pgntttdfdg stnitqckts snsvttyetc qtyerpiaft srskklwiqf ksnegnsarg
      721 fqvpyvtydd a
//
LOCUS       XP_054225531             694 aa            linear   PRI 05-AUG-2025
DEFINITION  signal peptide, CUB and EGF-like domain-containing protein 2
            isoform X27 [Homo sapiens].
ACCESSION   XP_054225531
VERSION     XP_054225531.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369556.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..694
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..694
                     /product="signal peptide, CUB and EGF-like
                     domain-containing protein 2 isoform X27"
                     /calculated_mol_wt=75097
     Region          48..83
                     /region_name="EGF_3"
                     /note="EGF domain; pfam12947"
                     /db_xref="CDD:463759"
     Region          94..125
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          131..166
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          176..212
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          216..251
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          285..320
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          <311..360
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          <358..394
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          406..441
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     CDS             1..694
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /coded_by="XM_054369556.1:71..2155"
                     /db_xref="GeneID:57758"
                     /db_xref="HGNC:HGNC:30425"
                     /db_xref="MIM:611747"
ORIGIN      
        1 mgvagrnrpg aawavlllll lppplllaga vppgrgraag pqedvdecaq glddchadal
       61 cqntptsykc sckpgyqgeg rqcedidecg nelnggcvhd clnipgnyrc tcfdgfmlah
      121 dghncldvde clennggcqh tcvnvmgsye ccckegffls dnqhtcihrs eeglscmnkd
      181 hgcshickea prgsvacecr pgfelaknqr dciltcnhgn ggcqhscddt adgpecschp
      241 qykmhtdgrs cleredtvle vtesnttsvv dgdkrvkrrl lmetcavnng gcdrtckdts
      301 tgvhcscpvg ftlqldgktc kdidecqtrn ggcdhfckni vgsfdcgckk gfklltdeks
      361 cqdvdecsld rtcdhscinh pgtfacacnr gytlygfthc gdtnecsinn ggcqqvcvnt
      421 vgsyecqchp gyklhwnkkd cvevkgllpt svsprvslhc gksgggdgcf lrchsgihls
      481 sglqgaysvt cgsssplrnk qqksndsafg dvttirtsvt fklnegkcsl knaelfpegl
      541 rpalpekhss vkesfryvnl tcssgkqvpg apgrpstpke mfitvefele tnqkevtasc
      601 dlscivkrte krlrkairtl rkavhreqfh lqlsgmnldv akkpprtser qaescgvgqg
      661 haenqcgepm clvsgapkhw mnfvaltasn qvqv
//
LOCUS       XP_054225532             585 aa            linear   PRI 05-AUG-2025
DEFINITION  signal peptide, CUB and EGF-like domain-containing protein 2
            isoform X28 [Homo sapiens].
ACCESSION   XP_054225532
VERSION     XP_054225532.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369557.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..585
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..585
                     /product="signal peptide, CUB and EGF-like
                     domain-containing protein 2 isoform X28"
                     /calculated_mol_wt=63607
     Region          48..83
                     /region_name="EGF_3"
                     /note="EGF domain; pfam12947"
                     /db_xref="CDD:463759"
     Region          94..125
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          131..166
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          176..212
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          216..251
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          285..320
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          <311..360
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          <358..394
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     CDS             1..585
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /coded_by="XM_054369557.1:71..1828"
                     /db_xref="GeneID:57758"
                     /db_xref="HGNC:HGNC:30425"
                     /db_xref="MIM:611747"
ORIGIN      
        1 mgvagrnrpg aawavlllll lppplllaga vppgrgraag pqedvdecaq glddchadal
       61 cqntptsykc sckpgyqgeg rqcedidecg nelnggcvhd clnipgnyrc tcfdgfmlah
      121 dghncldvde clennggcqh tcvnvmgsye ccckegffls dnqhtcihrs eeglscmnkd
      181 hgcshickea prgsvacecr pgfelaknqr dciltcnhgn ggcqhscddt adgpecschp
      241 qykmhtdgrs cleredtvle vtesnttsvv dgdkrvkrrl lmetcavnng gcdrtckdts
      301 tgvhcscpvg ftlqldgktc kdidecqtrn ggcdhfckni vgsfdcgckk gfklltdeks
      361 cqdvdecsld rtcdhscinh pgtfacacnr gytlygfthc gdvttirtsv tfklnegkcs
      421 lknaelfpeg lrpalpekhs svkesfryvn ltcssgkqvp gapgrpstpk emfitvefel
      481 etnqkevtas cdlscivkrt ekrlrkairt lrkavhreqf hlqlsgmnld vakkpprtse
      541 rqaescgvgq ghaenqcgep mclvsgapkh wmnfvaltas nqvqv
//
LOCUS       XP_054225533             539 aa            linear   PRI 05-AUG-2025
DEFINITION  signal peptide, CUB and EGF-like domain-containing protein 2
            isoform X29 [Homo sapiens].
ACCESSION   XP_054225533
VERSION     XP_054225533.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369558.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..539
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..539
                     /product="signal peptide, CUB and EGF-like
                     domain-containing protein 2 isoform X29"
                     /calculated_mol_wt=58525
     Region          48..83
                     /region_name="EGF_3"
                     /note="EGF domain; pfam12947"
                     /db_xref="CDD:463759"
     Region          94..125
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          131..166
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          176..212
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          216..251
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          285..320
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          <311..360
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          <358..394
                     /region_name="vWFA"
                     /note="Von Willebrand factor type A (vWA) domain was
                     originally found in the blood coagulation protein von
                     Willebrand factor (vWF). Typically, the vWA domain is made
                     up of approximately 200 amino acid residues folded into a
                     classic a/b para-rossmann type of...; cl00057"
                     /db_xref="CDD:469594"
     Region          406..441
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     CDS             1..539
                     /gene="SCUBE2"
                     /gene_synonym="CEGB1; CEGF1; CEGP1; scube/You"
                     /coded_by="XM_054369558.1:71..1690"
                     /db_xref="GeneID:57758"
                     /db_xref="HGNC:HGNC:30425"
                     /db_xref="MIM:611747"
ORIGIN      
        1 mgvagrnrpg aawavlllll lppplllaga vppgrgraag pqedvdecaq glddchadal
       61 cqntptsykc sckpgyqgeg rqcedidecg nelnggcvhd clnipgnyrc tcfdgfmlah
      121 dghncldvde clennggcqh tcvnvmgsye ccckegffls dnqhtcihrs eeglscmnkd
      181 hgcshickea prgsvacecr pgfelaknqr dciltcnhgn ggcqhscddt adgpecschp
      241 qykmhtdgrs cleredtvle vtesnttsvv dgdkrvkrrl lmetcavnng gcdrtckdts
      301 tgvhcscpvg ftlqldgktc kdidecqtrn ggcdhfckni vgsfdcgckk gfklltdeks
      361 cqdvdecsld rtcdhscinh pgtfacacnr gytlygfthc gdtnecsinn ggcqqvcvnt
      421 vgsyecqchp gyklhwnkkd cvascdlsci vkrtekrlrk airtlrkavh reqfhlqlsg
      481 mnldvakkpp rtserqaesc gvgqghaenq cgepmclvsg apkhwmnfva ltasnqvqv
//
LOCUS       XP_054225534            1321 aa            linear   PRI 05-AUG-2025
DEFINITION  receptor-type tyrosine-protein phosphatase eta isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225534
VERSION     XP_054225534.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369559.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1321
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1321
                     /product="receptor-type tyrosine-protein phosphatase eta
                     isoform X1"
                     /calculated_mol_wt=143830
     Region          103..189
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(103,162,178)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Site            order(179..180,182..183)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          <356..679
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     Region          819..949
                     /region_name="PTP_tm"
                     /note="TM proximal of protein tyrosine phosphatase,
                     receptor type J; pfam18861"
                     /db_xref="CDD:465889"
     Region          1053..1281
                     /region_name="R-PTPc-J"
                     /note="catalytic domain of receptor-type tyrosine-protein
                     phosphatase J; cd14615"
                     /db_xref="CDD:350463"
     CDS             1..1321
                     /gene="PTPRJ"
                     /gene_synonym="CD148; DEP1; HPTP eta; HPTPeta; R-PTP-ETA;
                     R-PTP-J; SCC1; THC10"
                     /coded_by="XM_054369559.1:16..3981"
                     /db_xref="GeneID:5795"
                     /db_xref="HGNC:HGNC:9673"
                     /db_xref="MIM:600925"
ORIGIN      
        1 mtrgggsgss rgsrdrilca ggtpspipdp svatvatgen gitqisstae sfhkqngtgt
       61 pqvetntsed gessgandsl rtpeqgsngt dgasqktpss tgpspvfdik avsisptnvi
      121 ltwksndtaa seykyvvkhk menektitvv hqpwcnitgl rpatsyvfsi tpgignetwg
      181 dprvikvite pipvsdlrva ltgvrkaals wsngngtasc rvllesigsh eeltqdsrlq
      241 vnisglkpgv qyninpyllq snktkgdplg teggldasnt ersragspta pvhdeslvgp
      301 vdpssgqqsr dtevllvgle pgtrynatvy sqaangtegq pqaiefrtna iqvfdvtavn
      361 isatsltliw kvsdnesssn ytykihvage tdssnlnvse pravipglrs stfynitvcp
      421 vlgdiegtpg flqvhtppvp vsdfrvtvvs tteiglawss hdaesfqmhi tqegagnsrv
      481 eittnqsiii gglfpgtkyc feivpkgpng tegasrtvcn rtvpsavfdi hvvyvtttem
      541 wldwkspdga seyvyhlvie skhgsnhtst ydkaitlqgl ipgtlyniti spevdhvwgd
      601 pnstaqytrp snvsnidvst nttaatlswq nfddasptys yclliekagn ssnatqvvtd
      661 igitdatvte lipgssytve ifaqvgdgik slepgrksfc tdpasmasfd cevvpkepal
      721 vlkwtcppga nagfelevss gawnnathle scssengtey rtevtylnfs tsynisittv
      781 scgkmaaptr ntcttgitdp pppdgspnit svshnsvkvk fsgfeashgp ikayaviltt
      841 geaghpsadv lkytyedfkk gasdtyvtyl irteekgrsq slsevlkyei dvgnesttlg
      901 yyngkleplg syracvagft nitfhpqnkg lidgaesyvs fsrysdavsl pqdpgvicga
      961 vfgcifgalv ivtvggfifw rkkrkdaknn evsfsqikpk ksklirvenf eayfkkqqad
     1021 sncgfaeeye dlklvgisqp kyaaelaenr gknrynnvlp ydisrvklsv qthstddyin
     1081 anympgyhsk kdfiatqgpl pntlkdfwrm vweknvyaii mltkcveqgr tkceeywpsk
     1141 qaqdygditv amtseivlpe wtirdftvkn iqtseshplr qfhftswpdh gvpdttdlli
     1201 nfrylvrdym kqsppespil vhcsagvgrt gtfiaidrli yqienentvd vygivydlrm
     1261 hrplmvqted qyvflnqcvl divrsqkdsk vdliyqntta mtiyenlapv ttfgktngyi
     1321 a
//
LOCUS       XP_054225535            1104 aa            linear   PRI 05-AUG-2025
DEFINITION  receptor-type tyrosine-protein phosphatase eta isoform X2 [Homo
            sapiens].
ACCESSION   XP_054225535
VERSION     XP_054225535.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369560.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1104
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1104
                     /product="receptor-type tyrosine-protein phosphatase eta
                     isoform X2"
                     /calculated_mol_wt=117896
     Region          233..319
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(233,292,308)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Site            order(309..310,312..313)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          <486..809
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     Region          949..1079
                     /region_name="PTP_tm"
                     /note="TM proximal of protein tyrosine phosphatase,
                     receptor type J; pfam18861"
                     /db_xref="CDD:465889"
     CDS             1..1104
                     /gene="PTPRJ"
                     /gene_synonym="CD148; DEP1; HPTP eta; HPTPeta; R-PTP-ETA;
                     R-PTP-J; SCC1; THC10"
                     /coded_by="XM_054369560.1:13..3327"
                     /db_xref="GeneID:5795"
                     /db_xref="HGNC:HGNC:9673"
                     /db_xref="MIM:600925"
ORIGIN      
        1 mtrgggsgss rgsrdrvaar wgwaplappr eaparsgtrp prgsrarlrr vaaaaaaaam
       61 spgkpgagga gtrrtgwrrr rrrrrqeaat tvpglgrtag pdsrvrgtfq gargmkpaar
      121 earlpprspg lrwalpllll llrlgqilca ggtpspipdp svatvatgen gitqisstae
      181 sfhkqngtgt pqvetntsed gessgandsl rtpeqgsngt dgasqktpss tgpspvfdik
      241 avsisptnvi ltwksndtaa seykyvvkhk menektitvv hqpwcnitgl rpatsyvfsi
      301 tpgignetwg dprvikvite pipvsdlrva ltgvrkaals wsngngtasc rvllesigsh
      361 eeltqdsrlq vnisglkpgv qyninpyllq snktkgdplg teggldasnt ersragspta
      421 pvhdeslvgp vdpssgqqsr dtevllvgle pgtrynatvy sqaangtegq pqaiefrtna
      481 iqvfdvtavn isatsltliw kvsdnesssn ytykihvage tdssnlnvse pravipglrs
      541 stfynitvcp vlgdiegtpg flqvhtppvp vsdfrvtvvs tteiglawss hdaesfqmhi
      601 tqegagnsrv eittnqsiii gglfpgtkyc feivpkgpng tegasrtvcn rtvpsavfdi
      661 hvvyvtttem wldwkspdga seyvyhlvie skhgsnhtst ydkaitlqgl ipgtlyniti
      721 spevdhvwgd pnstaqytrp snvsnidvst nttaatlswq nfddasptys yclliekagn
      781 ssnatqvvtd igitdatvte lipgssytve ifaqvgdgik slepgrksfc tdpasmasfd
      841 cevvpkepal vlkwtcppga nagfelevss gawnnathle scssengtey rtevtylnfs
      901 tsynisittv scgkmaaptr ntcttgitdp pppdgspnit svshnsvkvk fsgfeashgp
      961 ikayaviltt geaghpsadv lkytyedfkk gasdtyvtyl irteekgrsq slsevlkyei
     1021 dvgnesttlg yyngkleplg syracvagft nitfhpqnkg lidgaesyvs fsrysdavsl
     1081 pqdpgkmqri mkcpflklnl knls
//
LOCUS       XP_054225536             192 aa            linear   PRI 05-AUG-2025
DEFINITION  6-pyruvoyl tetrahydrobiopterin synthase isoform X1 [Homo sapiens].
ACCESSION   XP_054225536
VERSION     XP_054225536.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369561.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..192
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..192
                     /product="6-pyruvoyl tetrahydrobiopterin synthase isoform
                     X1"
                     /calculated_mol_wt=20742
     CDS             1..192
                     /gene="PTS"
                     /gene_synonym="PTPS"
                     /coded_by="XM_054369561.1:1482..2060"
                     /db_xref="GeneID:5805"
                     /db_xref="HGNC:HGNC:9689"
                     /db_xref="MIM:612719"
ORIGIN      
        1 mvtvraslqs efvclilsdt sdavkqgqsg swivtthadi kqtlpsaech ertvttlgph
       61 geggrnfvsl gaqggqlllp tgniclelfc aihnlpplhp sfapgmlqss lhcallivrh
      121 vallsplsgi lppfsvcerk sslifkalvl efqfclcfrn tflpapflqt llllwmlpqa
      181 ctvslltlyc nd
//
LOCUS       XP_054225537             184 aa            linear   PRI 05-AUG-2025
DEFINITION  6-pyruvoyl tetrahydrobiopterin synthase isoform X2 [Homo sapiens].
ACCESSION   XP_054225537
VERSION     XP_054225537.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369562.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..184
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..184
                     /product="6-pyruvoyl tetrahydrobiopterin synthase isoform
                     X2"
                     /calculated_mol_wt=19834
     CDS             1..184
                     /gene="PTS"
                     /gene_synonym="PTPS"
                     /coded_by="XM_054369562.1:212..766"
                     /db_xref="GeneID:5805"
                     /db_xref="HGNC:HGNC:9689"
                     /db_xref="MIM:612719"
ORIGIN      
        1 mtacfsrvss dtsdavkqgq sgswivttha dikqtlpsae chertvttlg phgeggrnfv
       61 slgaqggqll lptgniclel fcaihnlppl hpsfapgmlq sslhcalliv rhvallspls
      121 gilppfsvce rksslifkal vlefqfclcf rntflpapfl qtllllwmlp qactvslltl
      181 ycnd
//
LOCUS       XP_054225538             145 aa            linear   PRI 05-AUG-2025
DEFINITION  6-pyruvoyl tetrahydrobiopterin synthase isoform X3 [Homo sapiens].
ACCESSION   XP_054225538
VERSION     XP_054225538.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369563.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..145
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..145
                     /product="6-pyruvoyl tetrahydrobiopterin synthase isoform
                     X3"
                     /calculated_mol_wt=16255
     Region          11..145
                     /region_name="PTPS"
                     /note="6-pyruvoyl tetrahydropterin synthase (PTPS). Folate
                     derivatives are essential cofactors in the biosynthesis of
                     purines, pyrimidines, and amino acids, as well as
                     formyl-tRNA. Mammalian cells are able to utilize
                     pre-formed folates after uptake by a...; cd00470"
                     /db_xref="CDD:238264"
     Site            order(11,63..73,106..112,142,144)
                     /site_type="other"
                     /note="homohexamer interface [polypeptide binding]"
                     /db_xref="CDD:238264"
     Site            order(13,15,17,19,54,56,58,128..129,131,133,139,141,143)
                     /site_type="other"
                     /note="putative substrate stabilizing pore"
                     /db_xref="CDD:238264"
     Site            order(24,26,43,49,51,89..90,107..108)
                     /site_type="active"
                     /note="pterin binding site [active]"
                     /db_xref="CDD:238264"
     CDS             1..145
                     /gene="PTS"
                     /gene_synonym="PTPS"
                     /coded_by="XM_054369563.1:17..454"
                     /db_xref="GeneID:5805"
                     /db_xref="HGNC:HGNC:9689"
                     /db_xref="MIM:612719"
ORIGIN      
        1 mstegggrrc qaqvsrrisf sashrlyskf lsdeenlklf gkcnnpnghg hnykvvvtvh
       61 geidpatgmv mnladlkkym eeaimqpldh knldmdvpyf advvsttenv avyiwdnlqk
      121 vlpvgvlykv kvyetdnniv vykge
//
LOCUS       XP_054225539             145 aa            linear   PRI 05-AUG-2025
DEFINITION  6-pyruvoyl tetrahydrobiopterin synthase isoform X3 [Homo sapiens].
ACCESSION   XP_054225539
VERSION     XP_054225539.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369564.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..145
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..145
                     /product="6-pyruvoyl tetrahydrobiopterin synthase isoform
                     X3"
                     /calculated_mol_wt=16255
     Region          11..145
                     /region_name="PTPS"
                     /note="6-pyruvoyl tetrahydropterin synthase (PTPS). Folate
                     derivatives are essential cofactors in the biosynthesis of
                     purines, pyrimidines, and amino acids, as well as
                     formyl-tRNA. Mammalian cells are able to utilize
                     pre-formed folates after uptake by a...; cd00470"
                     /db_xref="CDD:238264"
     Site            order(11,63..73,106..112,142,144)
                     /site_type="other"
                     /note="homohexamer interface [polypeptide binding]"
                     /db_xref="CDD:238264"
     Site            order(13,15,17,19,54,56,58,128..129,131,133,139,141,143)
                     /site_type="other"
                     /note="putative substrate stabilizing pore"
                     /db_xref="CDD:238264"
     Site            order(24,26,43,49,51,89..90,107..108)
                     /site_type="active"
                     /note="pterin binding site [active]"
                     /db_xref="CDD:238264"
     CDS             1..145
                     /gene="PTS"
                     /gene_synonym="PTPS"
                     /coded_by="XM_054369564.1:17..454"
                     /db_xref="GeneID:5805"
                     /db_xref="HGNC:HGNC:9689"
                     /db_xref="MIM:612719"
ORIGIN      
        1 mstegggrrc qaqvsrrisf sashrlyskf lsdeenlklf gkcnnpnghg hnykvvvtvh
       61 geidpatgmv mnladlkkym eeaimqpldh knldmdvpyf advvsttenv avyiwdnlqk
      121 vlpvgvlykv kvyetdnniv vykge
//
LOCUS       XP_054225540             224 aa            linear   PRI 05-AUG-2025
DEFINITION  pleckstrin homology domain-containing family B member 1 isoform X1
            [Homo sapiens].
ACCESSION   XP_054225540
VERSION     XP_054225540.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369565.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..224
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..224
                     /product="pleckstrin homology domain-containing family B
                     member 1 isoform X1"
                     /calculated_mol_wt=25102
     Region          1..108
                     /region_name="PH_evt"
                     /note="Evectin Pleckstrin homology (PH) domain; cd13265"
                     /db_xref="CDD:270085"
     Site            order(11,13..18,20,34,45,87)
                     /site_type="other"
                     /note="phosophoserine binding site [chemical binding]"
                     /db_xref="CDD:270085"
     CDS             1..224
                     /gene="PLEKHB1"
                     /gene_synonym="KPL1; PHR1; PHRET1"
                     /coded_by="XM_054369565.1:65..739"
                     /db_xref="GeneID:58473"
                     /db_xref="HGNC:HGNC:19079"
                     /db_xref="MIM:607651"
ORIGIN      
        1 malvrggwlw rqssilrrwk rnwfalwldg tlgyyhdeta qdeedrvlih fnvrdikigp
       61 echdvqppeg rsrdglltvn lreggrlhlc aetkddalaw ktalleanst papagatvpp
      121 rsrrvcskvr cvtrswspck verriwvrvy spyqdyyevv ppnaheatyv rsyygppyag
      181 pgvthvivre dpcysagapl amgmlagaat gaalgslmws pcwf
//
LOCUS       XP_054225541             189 aa            linear   PRI 05-AUG-2025
DEFINITION  pleckstrin homology domain-containing family B member 1 isoform X2
            [Homo sapiens].
ACCESSION   XP_054225541
VERSION     XP_054225541.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369566.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..189
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..189
                     /product="pleckstrin homology domain-containing family B
                     member 1 isoform X2"
                     /calculated_mol_wt=21123
     Region          1..108
                     /region_name="PH_evt"
                     /note="Evectin Pleckstrin homology (PH) domain; cd13265"
                     /db_xref="CDD:270085"
     Site            order(11,13..18,20,34,45,87)
                     /site_type="other"
                     /note="phosophoserine binding site [chemical binding]"
                     /db_xref="CDD:270085"
     CDS             1..189
                     /gene="PLEKHB1"
                     /gene_synonym="KPL1; PHR1; PHRET1"
                     /coded_by="XM_054369566.1:116..685"
                     /db_xref="GeneID:58473"
                     /db_xref="HGNC:HGNC:19079"
                     /db_xref="MIM:607651"
ORIGIN      
        1 malvrggwlw rqssilrrwk rnwfalwldg tlgyyhdeta qdeedrvlih fnvrdikigp
       61 echdvqppeg rsrdglltvn lreggrlhlc aetkddalaw ktalleanst pvrvyspyqd
      121 yyevvppnah eatyvrsyyg ppyagpgvth vivredpcys agaplamgml agaatgaalg
      181 slmwspcwf
//
LOCUS       XP_054225542             358 aa            linear   PRI 05-AUG-2025
DEFINITION  CREB/ATF bZIP transcription factor isoform X1 [Homo sapiens].
ACCESSION   XP_054225542
VERSION     XP_054225542.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369567.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..358
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..358
                     /product="CREB/ATF bZIP transcription factor isoform X1"
                     /calculated_mol_wt=37583
     Region          <219..260
                     /region_name="bZIP"
                     /note="Basic leucine zipper (bZIP) domain of bZIP
                     transcription factors: a DNA-binding and dimerization
                     domain; cl21462"
                     /db_xref="CDD:473870"
     Site            order(225,228..229,232..233,235..236,239..240,242..243,
                     246..247,249..250,253..254,256..257)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:269854"
     CDS             1..358
                     /gene="CREBZF"
                     /gene_synonym="SMILE; ZF"
                     /coded_by="XM_054369567.1:255..1331"
                     /db_xref="GeneID:58487"
                     /db_xref="HGNC:HGNC:24905"
                     /db_xref="MIM:606444"
ORIGIN      
        1 mrhsltklla asgsnsptrs espepaatcs lpsdltraaa geeetaaags pgrkqqfgde
       61 geleagrgsr ggvavrapsp eemeeeaias lpgeetedmd flsgleladl ldprqpdwhl
      121 dpglsspgpl sssgggsdsg glwrgdddde aaaaemqrfs dllqrllngi ggcssssdsg
      181 saekrrrksp gggggggsgn dnnqaatksp rkaaaaaarl nrlkkkeyvm glesrvrgla
      241 aenqelraen relgkrvqal qeesrylrav lanetglarl lsrlsgvglr lttslfrdsp
      301 agdhdyalpv gkqkqdllee ddsaggvclh vdkdkvsvef csacarkass slkifffr
//
LOCUS       XP_054225543             358 aa            linear   PRI 05-AUG-2025
DEFINITION  CREB/ATF bZIP transcription factor isoform X1 [Homo sapiens].
ACCESSION   XP_054225543
VERSION     XP_054225543.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369568.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..358
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..358
                     /product="CREB/ATF bZIP transcription factor isoform X1"
                     /calculated_mol_wt=37583
     Region          <219..260
                     /region_name="bZIP"
                     /note="Basic leucine zipper (bZIP) domain of bZIP
                     transcription factors: a DNA-binding and dimerization
                     domain; cl21462"
                     /db_xref="CDD:473870"
     Site            order(225,228..229,232..233,235..236,239..240,242..243,
                     246..247,249..250,253..254,256..257)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:269854"
     CDS             1..358
                     /gene="CREBZF"
                     /gene_synonym="SMILE; ZF"
                     /coded_by="XM_054369568.1:255..1331"
                     /db_xref="GeneID:58487"
                     /db_xref="HGNC:HGNC:24905"
                     /db_xref="MIM:606444"
ORIGIN      
        1 mrhsltklla asgsnsptrs espepaatcs lpsdltraaa geeetaaags pgrkqqfgde
       61 geleagrgsr ggvavrapsp eemeeeaias lpgeetedmd flsgleladl ldprqpdwhl
      121 dpglsspgpl sssgggsdsg glwrgdddde aaaaemqrfs dllqrllngi ggcssssdsg
      181 saekrrrksp gggggggsgn dnnqaatksp rkaaaaaarl nrlkkkeyvm glesrvrgla
      241 aenqelraen relgkrvqal qeesrylrav lanetglarl lsrlsgvglr lttslfrdsp
      301 agdhdyalpv gkqkqdllee ddsaggvclh vdkdkvsvef csacarkass slkifffr
//
LOCUS       XP_054225544             358 aa            linear   PRI 05-AUG-2025
DEFINITION  CREB/ATF bZIP transcription factor isoform X1 [Homo sapiens].
ACCESSION   XP_054225544
VERSION     XP_054225544.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369569.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..358
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..358
                     /product="CREB/ATF bZIP transcription factor isoform X1"
                     /calculated_mol_wt=37583
     Region          <219..260
                     /region_name="bZIP"
                     /note="Basic leucine zipper (bZIP) domain of bZIP
                     transcription factors: a DNA-binding and dimerization
                     domain; cl21462"
                     /db_xref="CDD:473870"
     Site            order(225,228..229,232..233,235..236,239..240,242..243,
                     246..247,249..250,253..254,256..257)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:269854"
     CDS             1..358
                     /gene="CREBZF"
                     /gene_synonym="SMILE; ZF"
                     /coded_by="XM_054369569.1:255..1331"
                     /db_xref="GeneID:58487"
                     /db_xref="HGNC:HGNC:24905"
                     /db_xref="MIM:606444"
ORIGIN      
        1 mrhsltklla asgsnsptrs espepaatcs lpsdltraaa geeetaaags pgrkqqfgde
       61 geleagrgsr ggvavrapsp eemeeeaias lpgeetedmd flsgleladl ldprqpdwhl
      121 dpglsspgpl sssgggsdsg glwrgdddde aaaaemqrfs dllqrllngi ggcssssdsg
      181 saekrrrksp gggggggsgn dnnqaatksp rkaaaaaarl nrlkkkeyvm glesrvrgla
      241 aenqelraen relgkrvqal qeesrylrav lanetglarl lsrlsgvglr lttslfrdsp
      301 agdhdyalpv gkqkqdllee ddsaggvclh vdkdkvsvef csacarkass slkifffr
//
LOCUS       XP_054225545             358 aa            linear   PRI 05-AUG-2025
DEFINITION  CREB/ATF bZIP transcription factor isoform X1 [Homo sapiens].
ACCESSION   XP_054225545
VERSION     XP_054225545.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369570.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..358
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..358
                     /product="CREB/ATF bZIP transcription factor isoform X1"
                     /calculated_mol_wt=37583
     Region          <219..260
                     /region_name="bZIP"
                     /note="Basic leucine zipper (bZIP) domain of bZIP
                     transcription factors: a DNA-binding and dimerization
                     domain; cl21462"
                     /db_xref="CDD:473870"
     Site            order(225,228..229,232..233,235..236,239..240,242..243,
                     246..247,249..250,253..254,256..257)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:269854"
     CDS             1..358
                     /gene="CREBZF"
                     /gene_synonym="SMILE; ZF"
                     /coded_by="XM_054369570.1:255..1331"
                     /db_xref="GeneID:58487"
                     /db_xref="HGNC:HGNC:24905"
                     /db_xref="MIM:606444"
ORIGIN      
        1 mrhsltklla asgsnsptrs espepaatcs lpsdltraaa geeetaaags pgrkqqfgde
       61 geleagrgsr ggvavrapsp eemeeeaias lpgeetedmd flsgleladl ldprqpdwhl
      121 dpglsspgpl sssgggsdsg glwrgdddde aaaaemqrfs dllqrllngi ggcssssdsg
      181 saekrrrksp gggggggsgn dnnqaatksp rkaaaaaarl nrlkkkeyvm glesrvrgla
      241 aenqelraen relgkrvqal qeesrylrav lanetglarl lsrlsgvglr lttslfrdsp
      301 agdhdyalpv gkqkqdllee ddsaggvclh vdkdkvsvef csacarkass slkifffr
//
LOCUS       XP_054225546             358 aa            linear   PRI 05-AUG-2025
DEFINITION  CREB/ATF bZIP transcription factor isoform X1 [Homo sapiens].
ACCESSION   XP_054225546
VERSION     XP_054225546.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369571.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..358
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..358
                     /product="CREB/ATF bZIP transcription factor isoform X1"
                     /calculated_mol_wt=37583
     Region          <219..260
                     /region_name="bZIP"
                     /note="Basic leucine zipper (bZIP) domain of bZIP
                     transcription factors: a DNA-binding and dimerization
                     domain; cl21462"
                     /db_xref="CDD:473870"
     Site            order(225,228..229,232..233,235..236,239..240,242..243,
                     246..247,249..250,253..254,256..257)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:269854"
     CDS             1..358
                     /gene="CREBZF"
                     /gene_synonym="SMILE; ZF"
                     /coded_by="XM_054369571.1:255..1331"
                     /db_xref="GeneID:58487"
                     /db_xref="HGNC:HGNC:24905"
                     /db_xref="MIM:606444"
ORIGIN      
        1 mrhsltklla asgsnsptrs espepaatcs lpsdltraaa geeetaaags pgrkqqfgde
       61 geleagrgsr ggvavrapsp eemeeeaias lpgeetedmd flsgleladl ldprqpdwhl
      121 dpglsspgpl sssgggsdsg glwrgdddde aaaaemqrfs dllqrllngi ggcssssdsg
      181 saekrrrksp gggggggsgn dnnqaatksp rkaaaaaarl nrlkkkeyvm glesrvrgla
      241 aenqelraen relgkrvqal qeesrylrav lanetglarl lsrlsgvglr lttslfrdsp
      301 agdhdyalpv gkqkqdllee ddsaggvclh vdkdkvsvef csacarkass slkifffr
//
LOCUS       XP_054225547             358 aa            linear   PRI 05-AUG-2025
DEFINITION  CREB/ATF bZIP transcription factor isoform X1 [Homo sapiens].
ACCESSION   XP_054225547
VERSION     XP_054225547.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369572.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..358
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..358
                     /product="CREB/ATF bZIP transcription factor isoform X1"
                     /calculated_mol_wt=37583
     Region          <219..260
                     /region_name="bZIP"
                     /note="Basic leucine zipper (bZIP) domain of bZIP
                     transcription factors: a DNA-binding and dimerization
                     domain; cl21462"
                     /db_xref="CDD:473870"
     Site            order(225,228..229,232..233,235..236,239..240,242..243,
                     246..247,249..250,253..254,256..257)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:269854"
     CDS             1..358
                     /gene="CREBZF"
                     /gene_synonym="SMILE; ZF"
                     /coded_by="XM_054369572.1:255..1331"
                     /db_xref="GeneID:58487"
                     /db_xref="HGNC:HGNC:24905"
                     /db_xref="MIM:606444"
ORIGIN      
        1 mrhsltklla asgsnsptrs espepaatcs lpsdltraaa geeetaaags pgrkqqfgde
       61 geleagrgsr ggvavrapsp eemeeeaias lpgeetedmd flsgleladl ldprqpdwhl
      121 dpglsspgpl sssgggsdsg glwrgdddde aaaaemqrfs dllqrllngi ggcssssdsg
      181 saekrrrksp gggggggsgn dnnqaatksp rkaaaaaarl nrlkkkeyvm glesrvrgla
      241 aenqelraen relgkrvqal qeesrylrav lanetglarl lsrlsgvglr lttslfrdsp
      301 agdhdyalpv gkqkqdllee ddsaggvclh vdkdkvsvef csacarkass slkifffr
//
LOCUS       XP_054225548             358 aa            linear   PRI 05-AUG-2025
DEFINITION  CREB/ATF bZIP transcription factor isoform X1 [Homo sapiens].
ACCESSION   XP_054225548
VERSION     XP_054225548.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369573.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..358
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..358
                     /product="CREB/ATF bZIP transcription factor isoform X1"
                     /calculated_mol_wt=37583
     Region          <219..260
                     /region_name="bZIP"
                     /note="Basic leucine zipper (bZIP) domain of bZIP
                     transcription factors: a DNA-binding and dimerization
                     domain; cl21462"
                     /db_xref="CDD:473870"
     Site            order(225,228..229,232..233,235..236,239..240,242..243,
                     246..247,249..250,253..254,256..257)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:269854"
     CDS             1..358
                     /gene="CREBZF"
                     /gene_synonym="SMILE; ZF"
                     /coded_by="XM_054369573.1:255..1331"
                     /db_xref="GeneID:58487"
                     /db_xref="HGNC:HGNC:24905"
                     /db_xref="MIM:606444"
ORIGIN      
        1 mrhsltklla asgsnsptrs espepaatcs lpsdltraaa geeetaaags pgrkqqfgde
       61 geleagrgsr ggvavrapsp eemeeeaias lpgeetedmd flsgleladl ldprqpdwhl
      121 dpglsspgpl sssgggsdsg glwrgdddde aaaaemqrfs dllqrllngi ggcssssdsg
      181 saekrrrksp gggggggsgn dnnqaatksp rkaaaaaarl nrlkkkeyvm glesrvrgla
      241 aenqelraen relgkrvqal qeesrylrav lanetglarl lsrlsgvglr lttslfrdsp
      301 agdhdyalpv gkqkqdllee ddsaggvclh vdkdkvsvef csacarkass slkifffr
//
LOCUS       XP_054225549             354 aa            linear   PRI 05-AUG-2025
DEFINITION  CREB/ATF bZIP transcription factor isoform X2 [Homo sapiens].
ACCESSION   XP_054225549
VERSION     XP_054225549.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369574.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..354
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..354
                     /product="CREB/ATF bZIP transcription factor isoform X2"
                     /calculated_mol_wt=37003
     Region          <219..260
                     /region_name="bZIP"
                     /note="Basic leucine zipper (bZIP) domain of bZIP
                     transcription factors: a DNA-binding and dimerization
                     domain; cl21462"
                     /db_xref="CDD:473870"
     Site            order(225,228..229,232..233,235..236,239..240,242..243,
                     246..247,249..250,253..254,256..257)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:269854"
     CDS             1..354
                     /gene="CREBZF"
                     /gene_synonym="SMILE; ZF"
                     /coded_by="XM_054369574.1:255..1319"
                     /db_xref="GeneID:58487"
                     /db_xref="HGNC:HGNC:24905"
                     /db_xref="MIM:606444"
ORIGIN      
        1 mrhsltklla asgsnsptrs espepaatcs lpsdltraaa geeetaaags pgrkqqfgde
       61 geleagrgsr ggvavrapsp eemeeeaias lpgeetedmd flsgleladl ldprqpdwhl
      121 dpglsspgpl sssgggsdsg glwrgdddde aaaaemqrfs dllqrllngi ggcssssdsg
      181 saekrrrksp gggggggsgn dnnqaatksp rkaaaaaarl nrlkkkeyvm glesrvrgla
      241 aenqelraen relgkrvqal qeesrylrav lanetglarl lsrlsgvglr lttslfrdsp
      301 agdhdyalpv gkqkqdllee ddsaggvclh vdkdkvsvef csacarkass slkm
//
LOCUS       XP_054225550             354 aa            linear   PRI 05-AUG-2025
DEFINITION  CREB/ATF bZIP transcription factor isoform X2 [Homo sapiens].
ACCESSION   XP_054225550
VERSION     XP_054225550.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369575.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..354
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..354
                     /product="CREB/ATF bZIP transcription factor isoform X2"
                     /calculated_mol_wt=37003
     Region          <219..260
                     /region_name="bZIP"
                     /note="Basic leucine zipper (bZIP) domain of bZIP
                     transcription factors: a DNA-binding and dimerization
                     domain; cl21462"
                     /db_xref="CDD:473870"
     Site            order(225,228..229,232..233,235..236,239..240,242..243,
                     246..247,249..250,253..254,256..257)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:269854"
     CDS             1..354
                     /gene="CREBZF"
                     /gene_synonym="SMILE; ZF"
                     /coded_by="XM_054369575.1:255..1319"
                     /db_xref="GeneID:58487"
                     /db_xref="HGNC:HGNC:24905"
                     /db_xref="MIM:606444"
ORIGIN      
        1 mrhsltklla asgsnsptrs espepaatcs lpsdltraaa geeetaaags pgrkqqfgde
       61 geleagrgsr ggvavrapsp eemeeeaias lpgeetedmd flsgleladl ldprqpdwhl
      121 dpglsspgpl sssgggsdsg glwrgdddde aaaaemqrfs dllqrllngi ggcssssdsg
      181 saekrrrksp gggggggsgn dnnqaatksp rkaaaaaarl nrlkkkeyvm glesrvrgla
      241 aenqelraen relgkrvqal qeesrylrav lanetglarl lsrlsgvglr lttslfrdsp
      301 agdhdyalpv gkqkqdllee ddsaggvclh vdkdkvsvef csacarkass slkm
//
LOCUS       XP_054225551             487 aa            linear   PRI 05-AUG-2025
DEFINITION  guanine nucleotide exchange factor for Rab-3A isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225551
VERSION     XP_054225551.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369576.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..487
                     /product="guanine nucleotide exchange factor for Rab-3A
                     isoform X1"
                     /calculated_mol_wt=53096
     Region          80..>206
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          <162..206
                     /region_name="Sec2p"
                     /note="GDP/GTP exchange factor Sec2p; pfam06428"
                     /db_xref="CDD:428938"
     Region          263..403
                     /region_name="Rab11BD_RAB3IP_like"
                     /note="Rab11 binding domain of Rab-3A-interacting protein
                     (RAB3IP), Rab-3A-interacting-like protein 1 (RAB3IL1) and
                     similar proteins; cl41767"
                     /db_xref="CDD:425398"
     Site            order(322..327,382,385..386,389,393,398..400)
                     /site_type="other"
                     /note="Rab11 binding site [polypeptide binding]"
                     /db_xref="CDD:411033"
     CDS             1..487
                     /gene="RAB3IL1"
                     /gene_synonym="GRAB"
                     /coded_by="XM_054369576.1:93..1556"
                     /db_xref="GeneID:5866"
                     /db_xref="HGNC:HGNC:9780"
                     /db_xref="MIM:621025"
ORIGIN      
        1 mdsseehagc pargtcpvfl amsagtvrya psglcpvleg nlreepwgtd sppqpdqglp
       61 pplaavpvpw kstdpcqghr espgalvets ageeaqgqeg paaaqldvlr lrsssmeire
      121 kgseflkeel hraqkelklk deecerlskv reqleqelee ltaslfeeah kmvreanmkq
      181 aasekqlkea rgkidmlqae vtalktlvit stpaspnrel hpqllsptka gprkghsrhk
      241 stsstlcpav cpaaghtltp dregkevdti lfaefqawre sptldktcpf lervyredvg
      301 pcldftmqel svlvraaved ntltiepvas qtlptvkvae vdcsstntca lsgltrtcrh
      361 rirlgdsksh yyispssrar itavcnffty iryiqqglvr qdahsarpgs pllhqpllaa
      421 esspepvwpd plskelsplh pggqvlleak akacwvltpa rsldgrcgpr ltaqgpcetp
      481 grhlclv
//
LOCUS       XP_054225552             446 aa            linear   PRI 05-AUG-2025
DEFINITION  guanine nucleotide exchange factor for Rab-3A isoform X2 [Homo
            sapiens].
ACCESSION   XP_054225552
VERSION     XP_054225552.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369577.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..446
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..446
                     /product="guanine nucleotide exchange factor for Rab-3A
                     isoform X2"
                     /calculated_mol_wt=48807
     Region          39..>165
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          <121..165
                     /region_name="Sec2p"
                     /note="GDP/GTP exchange factor Sec2p; pfam06428"
                     /db_xref="CDD:428938"
     Region          222..362
                     /region_name="Rab11BD_RAB3IP_like"
                     /note="Rab11 binding domain of Rab-3A-interacting protein
                     (RAB3IP), Rab-3A-interacting-like protein 1 (RAB3IL1) and
                     similar proteins; cl41767"
                     /db_xref="CDD:425398"
     Site            order(281..286,341,344..345,348,352,357..359)
                     /site_type="other"
                     /note="Rab11 binding site [polypeptide binding]"
                     /db_xref="CDD:411033"
     CDS             1..446
                     /gene="RAB3IL1"
                     /gene_synonym="GRAB"
                     /coded_by="XM_054369577.1:512..1852"
                     /db_xref="GeneID:5866"
                     /db_xref="HGNC:HGNC:9780"
                     /db_xref="MIM:621025"
ORIGIN      
        1 mdsarlqsas ppqpdqglpp plaavpvpwk stdpcqghre spgalvetsa geeaqgqegp
       61 aaaqldvlrl rsssmeirek gseflkeelh raqkelklkd eecerlskvr eqleqeleel
      121 taslfeeahk mvreanmkqa asekqlkear gkidmlqaev talktlvits tpaspnrelh
      181 pqllsptkag prkghsrhks tsstlcpavc paaghtltpd regkevdtil faefqawres
      241 ptldktcpfl ervyredvgp cldftmqels vlvraavedn tltiepvasq tlptvkvaev
      301 dcsstntcal sgltrtcrhr irlgdskshy yispssrari tavcnfftyi ryiqqglvrq
      361 dahsarpgsp llhqpllaae sspepvwpdp lskelsplhp ggqvlleaka kacwvltpar
      421 sldgrcgprl taqgpcetpg rhlclv
//
LOCUS       XP_054225553             440 aa            linear   PRI 05-AUG-2025
DEFINITION  guanine nucleotide exchange factor for Rab-3A isoform X3 [Homo
            sapiens].
ACCESSION   XP_054225553
VERSION     XP_054225553.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369578.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..440
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..440
                     /product="guanine nucleotide exchange factor for Rab-3A
                     isoform X3"
                     /calculated_mol_wt=48221
     Region          33..>159
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          <115..159
                     /region_name="Sec2p"
                     /note="GDP/GTP exchange factor Sec2p; pfam06428"
                     /db_xref="CDD:428938"
     Region          216..356
                     /region_name="Rab11BD_RAB3IP_like"
                     /note="Rab11 binding domain of Rab-3A-interacting protein
                     (RAB3IP), Rab-3A-interacting-like protein 1 (RAB3IL1) and
                     similar proteins; cl41767"
                     /db_xref="CDD:425398"
     Site            order(275..280,335,338..339,342,346,351..353)
                     /site_type="other"
                     /note="Rab11 binding site [polypeptide binding]"
                     /db_xref="CDD:411033"
     CDS             1..440
                     /gene="RAB3IL1"
                     /gene_synonym="GRAB"
                     /coded_by="XM_054369578.1:200..1522"
                     /db_xref="GeneID:5866"
                     /db_xref="HGNC:HGNC:9780"
                     /db_xref="MIM:621025"
ORIGIN      
        1 mwsgppqpdq glppplaavp vpwkstdpcq ghrespgalv etsageeaqg qegpaaaqld
       61 vlrlrsssme irekgseflk eelhraqkel klkdeecerl skvreqleqe leeltaslfe
      121 eahkmvrean mkqaasekql keargkidml qaevtalktl vitstpaspn relhpqllsp
      181 tkagprkghs rhkstsstlc pavcpaaght ltpdregkev dtilfaefqa wresptldkt
      241 cpflervyre dvgpcldftm qelsvlvraa vedntltiep vasqtlptvk vaevdcsstn
      301 tcalsgltrt crhrirlgds kshyyispss raritavcnf ftyiryiqqg lvrqdahsar
      361 pgspllhqpl laaesspepv wpdplskels plhpggqvll eakakacwvl tparsldgrc
      421 gprltaqgpc etpgrhlclv
//
LOCUS       XP_054225554             429 aa            linear   PRI 05-AUG-2025
DEFINITION  guanine nucleotide exchange factor for Rab-3A isoform X4 [Homo
            sapiens].
ACCESSION   XP_054225554
VERSION     XP_054225554.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369579.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..429
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..429
                     /product="guanine nucleotide exchange factor for Rab-3A
                     isoform X4"
                     /calculated_mol_wt=47380
     Region          <162..206
                     /region_name="Sec2p"
                     /note="GDP/GTP exchange factor Sec2p; pfam06428"
                     /db_xref="CDD:428938"
     Region          263..425
                     /region_name="Rab11BD_RAB3IL1"
                     /note="Rab11 binding domain of Rab-3A-interacting-like
                     protein 1 (RAB3IL1); cd21069"
                     /db_xref="CDD:411033"
     Site            order(321..327,382,385..386,389,393,398..402)
                     /site_type="other"
                     /note="putative Rab11 binding site [polypeptide binding]"
                     /db_xref="CDD:411033"
     CDS             1..429
                     /gene="RAB3IL1"
                     /gene_synonym="GRAB"
                     /coded_by="XM_054369579.1:93..1382"
                     /db_xref="GeneID:5866"
                     /db_xref="HGNC:HGNC:9780"
                     /db_xref="MIM:621025"
ORIGIN      
        1 mdsseehagc pargtcpvfl amsagtvrya psglcpvleg nlreepwgtd sppqpdqglp
       61 pplaavpvpw kstdpcqghr espgalvets ageeaqgqeg paaaqldvlr lrsssmeire
      121 kgseflkeel hraqkelklk deecerlskv reqleqelee ltaslfeeah kmvreanmkq
      181 aasekqlkea rgkidmlqae vtalktlvit stpaspnrel hpqllsptka gprkghsrhk
      241 stsstlcpav cpaaghtltp dregkevdti lfaefqawre sptldktcpf lervyredvg
      301 pcldftmqel svlvraaved ntltiepvas qtlptvkvae vdcsstntca lsgltrtcrh
      361 rirlgdsksh yyispssrar itavcnffty iryiqqglvr qdaepmfwei mrlrkemsla
      421 klgffpqea
//
LOCUS       XP_054225555             428 aa            linear   PRI 05-AUG-2025
DEFINITION  guanine nucleotide exchange factor for Rab-3A isoform X5 [Homo
            sapiens].
ACCESSION   XP_054225555
VERSION     XP_054225555.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369580.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..428
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..428
                     /product="guanine nucleotide exchange factor for Rab-3A
                     isoform X5"
                     /calculated_mol_wt=47309
     Region          <162..206
                     /region_name="Sec2p"
                     /note="GDP/GTP exchange factor Sec2p; pfam06428"
                     /db_xref="CDD:428938"
     Region          263..424
                     /region_name="Rab11BD_RAB3IP_like"
                     /note="Rab11 binding domain of Rab-3A-interacting protein
                     (RAB3IP), Rab-3A-interacting-like protein 1 (RAB3IL1) and
                     similar proteins; cl41767"
                     /db_xref="CDD:425398"
     Site            order(322..327,382,385..386,389,393,398..400)
                     /site_type="other"
                     /note="Rab11 binding site [polypeptide binding]"
                     /db_xref="CDD:411031"
     CDS             1..428
                     /gene="RAB3IL1"
                     /gene_synonym="GRAB"
                     /coded_by="XM_054369580.1:93..1379"
                     /db_xref="GeneID:5866"
                     /db_xref="HGNC:HGNC:9780"
                     /db_xref="MIM:621025"
ORIGIN      
        1 mdsseehagc pargtcpvfl amsagtvrya psglcpvleg nlreepwgtd sppqpdqglp
       61 pplaavpvpw kstdpcqghr espgalvets ageeaqgqeg paaaqldvlr lrsssmeire
      121 kgseflkeel hraqkelklk deecerlskv reqleqelee ltaslfeeah kmvreanmkq
      181 aasekqlkea rgkidmlqae vtalktlvit stpaspnrel hpqllsptka gprkghsrhk
      241 stsstlcpav cpaaghtltp dregkevdti lfaefqawre sptldktcpf lervyredvg
      301 pcldftmqel svlvraaved ntltiepvas qtlptvkvae vdcsstntca lsgltrtcrh
      361 rirlgdsksh yyispssrar itavcnffty iryiqqglvr qdepmfweim rlrkemslak
      421 lgffpqea
//
LOCUS       XP_054225556             414 aa            linear   PRI 05-AUG-2025
DEFINITION  guanine nucleotide exchange factor for Rab-3A isoform X6 [Homo
            sapiens].
ACCESSION   XP_054225556
VERSION     XP_054225556.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369581.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..414
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..414
                     /product="guanine nucleotide exchange factor for Rab-3A
                     isoform X6"
                     /calculated_mol_wt=45376
     Region          <162..>196
                     /region_name="Sec2p"
                     /note="GDP/GTP exchange factor Sec2p; pfam06428"
                     /db_xref="CDD:428938"
     Region          193..330
                     /region_name="Rab11BD_RAB3IP_like"
                     /note="Rab11 binding domain of Rab-3A-interacting protein
                     (RAB3IP), Rab-3A-interacting-like protein 1 (RAB3IL1) and
                     similar proteins; cl41767"
                     /db_xref="CDD:425398"
     Site            order(249..254,309,312..313,316,320,325..327)
                     /site_type="other"
                     /note="Rab11 binding site [polypeptide binding]"
                     /db_xref="CDD:411033"
     CDS             1..414
                     /gene="RAB3IL1"
                     /gene_synonym="GRAB"
                     /coded_by="XM_054369581.1:93..1337"
                     /db_xref="GeneID:5866"
                     /db_xref="HGNC:HGNC:9780"
                     /db_xref="MIM:621025"
ORIGIN      
        1 mdsseehagc pargtcpvfl amsagtvrya psglcpvleg nlreepwgtd sppqpdqglp
       61 pplaavpvpw kstdpcqghr espgalvets ageeaqgqeg paaaqldvlr lrsssmeire
      121 kgseflkeel hraqkelklk deecerlskv reqleqelee ltaslfeeah kmvreanmkq
      181 aasekqlkea rgkvdtilfa efqawrespt ldktcpfler vyredvgpcl dftmqelsvl
      241 vraavedntl tiepvasqtl ptvkvaevdc sstntcalsg ltrtcrhrir lgdskshyyi
      301 spssrarita vcnfftyiry iqqglvrqda hsarpgspll hqpllaaess pepvwpdpls
      361 kelsplhpgg qvlleakaka cwvltparsl dgrcgprlta qgpcetpgrh lclv
//
LOCUS       XP_054225557             381 aa            linear   PRI 05-AUG-2025
DEFINITION  guanine nucleotide exchange factor for Rab-3A isoform X7 [Homo
            sapiens].
ACCESSION   XP_054225557
VERSION     XP_054225557.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369582.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..381
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..381
                     /product="guanine nucleotide exchange factor for Rab-3A
                     isoform X7"
                     /calculated_mol_wt=42435
     Region          <115..159
                     /region_name="Sec2p"
                     /note="GDP/GTP exchange factor Sec2p; pfam06428"
                     /db_xref="CDD:428938"
     Region          216..377
                     /region_name="Rab11BD_RAB3IP_like"
                     /note="Rab11 binding domain of Rab-3A-interacting protein
                     (RAB3IP), Rab-3A-interacting-like protein 1 (RAB3IL1) and
                     similar proteins; cl41767"
                     /db_xref="CDD:425398"
     Site            order(275..280,335,338..339,342,346,351..353)
                     /site_type="other"
                     /note="Rab11 binding site [polypeptide binding]"
                     /db_xref="CDD:411031"
     CDS             1..381
                     /gene="RAB3IL1"
                     /gene_synonym="GRAB"
                     /coded_by="XM_054369582.1:200..1345"
                     /db_xref="GeneID:5866"
                     /db_xref="HGNC:HGNC:9780"
                     /db_xref="MIM:621025"
ORIGIN      
        1 mwsgppqpdq glppplaavp vpwkstdpcq ghrespgalv etsageeaqg qegpaaaqld
       61 vlrlrsssme irekgseflk eelhraqkel klkdeecerl skvreqleqe leeltaslfe
      121 eahkmvrean mkqaasekql keargkidml qaevtalktl vitstpaspn relhpqllsp
      181 tkagprkghs rhkstsstlc pavcpaaght ltpdregkev dtilfaefqa wresptldkt
      241 cpflervyre dvgpcldftm qelsvlvraa vedntltiep vasqtlptvk vaevdcsstn
      301 tcalsgltrt crhrirlgds kshyyispss raritavcnf ftyiryiqqg lvrqdepmfw
      361 eimrlrkems laklgffpqe a
//
LOCUS       XP_054225558             292 aa            linear   PRI 05-AUG-2025
DEFINITION  guanine nucleotide exchange factor for Rab-3A isoform X8 [Homo
            sapiens].
ACCESSION   XP_054225558
VERSION     XP_054225558.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369583.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..292
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..292
                     /product="guanine nucleotide exchange factor for Rab-3A
                     isoform X8"
                     /calculated_mol_wt=31729
     Region          68..208
                     /region_name="Rab11BD_RAB3IP_like"
                     /note="Rab11 binding domain of Rab-3A-interacting protein
                     (RAB3IP), Rab-3A-interacting-like protein 1 (RAB3IL1) and
                     similar proteins; cl41767"
                     /db_xref="CDD:425398"
     Site            order(127..132,187,190..191,194,198,203..205)
                     /site_type="other"
                     /note="Rab11 binding site [polypeptide binding]"
                     /db_xref="CDD:411033"
     CDS             1..292
                     /gene="RAB3IL1"
                     /gene_synonym="GRAB"
                     /coded_by="XM_054369583.1:93..971"
                     /db_xref="GeneID:5866"
                     /db_xref="HGNC:HGNC:9780"
                     /db_xref="MIM:621025"
ORIGIN      
        1 mlqaevtalk tlvitstpas pnrelhpqll sptkagprkg hsrhkstsst lcpavcpaag
       61 htltpdregk evdtilfaef qawresptld ktcpflervy redvgpcldf tmqelsvlvr
      121 aavedntlti epvasqtlpt vkvaevdcss tntcalsglt rtcrhrirlg dskshyyisp
      181 ssraritavc nfftyiryiq qglvrqdahs arpgspllhq pllaaesspe pvwpdplske
      241 lsplhpggqv lleakakacw vltparsldg rcgprltaqg pcetpgrhlc lv
//
LOCUS       XP_054225559             232 aa            linear   PRI 05-AUG-2025
DEFINITION  guanine nucleotide exchange factor for Rab-3A isoform X9 [Homo
            sapiens].
ACCESSION   XP_054225559
VERSION     XP_054225559.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369584.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..232
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..232
                     /product="guanine nucleotide exchange factor for Rab-3A
                     isoform X9"
                     /calculated_mol_wt=25456
     CDS             1..232
                     /gene="RAB3IL1"
                     /gene_synonym="GRAB"
                     /coded_by="XM_054369584.1:93..791"
                     /db_xref="GeneID:5866"
                     /db_xref="HGNC:HGNC:9780"
                     /db_xref="MIM:621025"
ORIGIN      
        1 mdsseehagc pargtcpvfl amsagtvrya psglcpvleg nlreepwgtd sppqpdqglp
       61 pplaavpvpw kstdpcqghr espgalvets ageeaqgqeg paaaqldvlr lrsssmeire
      121 kgseflkeel hraqkelklk deecerlskv reqleqelee ltaslfeeah kmvreanmkq
      181 aasekqlkea rgkphftkqk phsvwlsepg qvasslqawl pickistccr qr
//
LOCUS       XP_054225560             402 aa            linear   PRI 05-AUG-2025
DEFINITION  cell cycle checkpoint control protein RAD9A isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225560
VERSION     XP_054225560.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369585.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..402
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..402
                     /product="cell cycle checkpoint control protein RAD9A
                     isoform X1"
                     /calculated_mol_wt=43808
     Region          46..276
                     /region_name="Rad9"
                     /note="pfam04139"
                     /db_xref="CDD:427739"
     CDS             1..402
                     /gene="RAD9A"
                     /gene_synonym="RAD9"
                     /coded_by="XM_054369585.1:273..1481"
                     /db_xref="GeneID:5883"
                     /db_xref="HGNC:HGNC:9827"
                     /db_xref="MIM:603761"
ORIGIN      
        1 mgkggffsrw wrsgrtigqv ceqkqpegwv cgcplttsls llfvaqlslr tvnssrsaya
       61 cflfaplffq qyqaatpgqd llrckilmks flsvfrslam lektvekcci slngrssrlv
      121 vqlhckfgvr kthnlsfqdc eslqavfdpa scphmlrapa rvlgeavlpf spalaevtlg
      181 igrgrrvilr syheeeadst akamvtemcl geedfqqlqa qegvaitfcl kefrgllsfa
      241 esanlnlsih fdapgrpaif tikdslldgh fvlatlsdtd shsqdlgspe rhqpvpqlqa
      301 hstphpddfa nddidsymia mettignegs rvlpsislsp gpqppkspgp hseeedeaep
      361 stvpgtpppk kfrslffgsi lapvrspqgp spvlaedseg eg
//
LOCUS       XP_054225561             316 aa            linear   PRI 05-AUG-2025
DEFINITION  cell cycle checkpoint control protein RAD9A isoform X2 [Homo
            sapiens].
ACCESSION   XP_054225561
VERSION     XP_054225561.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369586.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..316
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..316
                     /product="cell cycle checkpoint control protein RAD9A
                     isoform X2"
                     /calculated_mol_wt=34872
     Region          46..257
                     /region_name="Rad9"
                     /note="pfam04139"
                     /db_xref="CDD:427739"
     CDS             1..316
                     /gene="RAD9A"
                     /gene_synonym="RAD9"
                     /coded_by="XM_054369586.1:275..1225"
                     /db_xref="GeneID:5883"
                     /db_xref="HGNC:HGNC:9827"
                     /db_xref="MIM:603761"
ORIGIN      
        1 mgkggffsrw wrsgrtigqv ceqkqpegwv cgcplttsls llfvaqlslr tvnssrsaya
       61 cflfaplffq qyqaatpgqd llrckilmks flsvfrslam lektvekcci slngrssrlv
      121 vqlhckfgvr kthnlsfqdc eslqavfdpa scphmlrapa rvlgeavlpf spalaevtlg
      181 igrgrrvilr syheeeadst akamvtemcl geedfqqlqa qegvaitfcl kefrgllsfa
      241 esanlnlsih fdapgppssp srtlcwtatl swphsqtptr tprtwapqsv tsqclssrlt
      301 ahptrttlpm ttltlt
//
LOCUS       XP_054225562             315 aa            linear   PRI 05-AUG-2025
DEFINITION  cell cycle checkpoint control protein RAD9A isoform X3 [Homo
            sapiens].
ACCESSION   XP_054225562
VERSION     XP_054225562.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369587.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..315
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..315
                     /product="cell cycle checkpoint control protein RAD9A
                     isoform X3"
                     /calculated_mol_wt=34071
     Region          <1..189
                     /region_name="Rad9"
                     /note="pfam04139"
                     /db_xref="CDD:427739"
     CDS             1..315
                     /gene="RAD9A"
                     /gene_synonym="RAD9"
                     /coded_by="XM_054369587.1:930..1877"
                     /db_xref="GeneID:5883"
                     /db_xref="HGNC:HGNC:9827"
                     /db_xref="MIM:603761"
ORIGIN      
        1 mqsflsvfrs lamlektvek ccislngrss rlvvqlhckf gvrkthnlsf qdceslqavf
       61 dpascphmlr aparvlgeav lpfspalaev tlgigrgrrv ilrsyheeea dstakamvte
      121 mclgeedfqq lqaqegvait fclkefrgll sfaesanlnl sihfdapgrp aiftikdsll
      181 dghfvlatls dtdshsqdlg sperhqpvpq lqahstphpd dfanddidsy miamettign
      241 egsrvlpsis lspgpqppks pgphseeede aepstvpgtp ppkkfrslff gsilapvrsp
      301 qgpspvlaed segeg
//
LOCUS       XP_054225563             279 aa            linear   PRI 05-AUG-2025
DEFINITION  cell cycle checkpoint control protein RAD9A isoform X4 [Homo
            sapiens].
ACCESSION   XP_054225563
VERSION     XP_054225563.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369588.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..279
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..279
                     /product="cell cycle checkpoint control protein RAD9A
                     isoform X4"
                     /calculated_mol_wt=29710
     Region          <12..153
                     /region_name="Rad9"
                     /note="pfam04139"
                     /db_xref="CDD:427739"
     CDS             1..279
                     /gene="RAD9A"
                     /gene_synonym="RAD9"
                     /coded_by="XM_054369588.1:293..1132"
                     /db_xref="GeneID:5883"
                     /db_xref="HGNC:HGNC:9827"
                     /db_xref="MIM:603761"
ORIGIN      
        1 magaaawwss ciassdcesl qavfdpascp hmlraparvl geavlpfspa laevtlgigr
       61 grrvilrsyh eeeadstaka mvtemclgee dfqqlqaqeg vaitfclkef rgllsfaesa
      121 nlnlsihfda pgrpaiftik dslldghfvl atlsdtdshs qdlgsperhq pvpqlqahst
      181 phpddfandd idsymiamet tignegsrvl psislspgpq ppkspgphse eedeaepstv
      241 pgtpppkkfr slffgsilap vrspqgpspv laedsegeg
//
LOCUS       XP_054225564             199 aa            linear   PRI 05-AUG-2025
DEFINITION  cell cycle checkpoint control protein RAD9A isoform X5 [Homo
            sapiens].
ACCESSION   XP_054225564
VERSION     XP_054225564.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369589.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..199
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..199
                     /product="cell cycle checkpoint control protein RAD9A
                     isoform X5"
                     /calculated_mol_wt=21271
     Region          <3..73
                     /region_name="Rad9"
                     /note="pfam04139"
                     /db_xref="CDD:427739"
     CDS             1..199
                     /gene="RAD9A"
                     /gene_synonym="RAD9"
                     /coded_by="XM_054369589.1:122..721"
                     /db_xref="GeneID:5883"
                     /db_xref="HGNC:HGNC:9827"
                     /db_xref="MIM:603761"
ORIGIN      
        1 mvtemclgee dfqqlqaqeg vaitfclkef rgllsfaesa nlnlsihfda pgrpaiftik
       61 dslldghfvl atlsdtdshs qdlgsperhq pvpqlqahst phpddfandd idsymiamet
      121 tignegsrvl psislspgpq ppkspgphse eedeaepstv pgtpppkkfr slffgsilap
      181 vrspqgpspv laedsegeg
//
LOCUS       XP_054225565            1043 aa            linear   PRI 05-AUG-2025
DEFINITION  V(D)J recombination-activating protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_054225565
VERSION     XP_054225565.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369590.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1043
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1043
                     /product="V(D)J recombination-activating protein 1 isoform
                     X1"
                     /calculated_mol_wt=119014
     Region          12..290
                     /region_name="RAG1_imp_bd"
                     /note="RAG1 importin binding; pfam12560"
                     /db_xref="CDD:463629"
     Region          289..334
                     /region_name="RING-HC_RAG1"
                     /note="RING finger, HC subclass, found in recombination
                     activating gene-1 (RAG-1) and similar proteins; cd16530"
                     /db_xref="CDD:319444"
     Region          354..383
                     /region_name="zf-RAG1"
                     /note="Recombination-activating protein 1 zinc-finger
                     domain; pfam10426"
                     /db_xref="CDD:431278"
     Region          386..1021
                     /region_name="RAG1"
                     /note="Recombination-activation protein 1 (RAG1),
                     recombinase; pfam12940"
                     /db_xref="CDD:315595"
     CDS             1..1043
                     /gene="RAG1"
                     /gene_synonym="RAG-1; RNF74"
                     /coded_by="XM_054369590.1:1302..4433"
                     /db_xref="GeneID:5896"
                     /db_xref="HGNC:HGNC:9831"
                     /db_xref="MIM:179615"
ORIGIN      
        1 maasfpptlg lssapdeiqh phikfsewkf klfrvrsfek tpeeaqkekk dsfegkpsle
       61 qspavldkad gqkpvptqpl lkahpkfskk fhdnekargk aihqanlrhl cricgnsfra
      121 dehnrrypvh gpvdgktlgl lrkkekrats wpdliakvfr idvkadvdsi hptefchncw
      181 simhrkfssa pcevyfprnv tmewhphtps cdicntarrg lkrkslqpnl qlskklktvl
      241 dqarqarqrk rraqarissk dvmkkiancs kihlstklla vdfpehfvks iscqicehil
      301 adpvetnckh vfcrvcilrc lkvmgsycps crypcfptdl espvksflsv lnslmvkcpa
      361 kecneevsle kynhhisshk eskeifvhin kggrprqhll sltrraqkhr lrelklqvka
      421 fadkeeggdv ksvcmtlfll alrarnehrq adeleaimqg kgsglqpavc lairvntfls
      481 csqyhkmyrt vkaitgrqif qplhalrnae kvllpgyhhf ewqpplknvs sstdvgiidg
      541 lsglsssvdd ypvdtiakrf rydsalvsal mdmeedileg mrsqdlddyl ngpftvvvke
      601 scdgmgdvse khgsgpvvpe kavrfsftim kitiahssqn vkvfeeakpn selcckplcl
      661 mladesdhet ltailsplia ereamkssel mlelggilrt fkfifrgtgy deklvreveg
      721 leasgsvyic tlcdatrlea sqnlvfhsit rshaenlery evwrsnpyhe sveelrdrvk
      781 gvsakpfiet vpsidalhcd ignaaefyki fqleigevyr npnaskeerk rwqatldkhl
      841 rkkmnlkpim rmngnfarkl mtketvdavc elipseerhe alrelmdlyl kmkpvwrssc
      901 pakecpeslc qysfnsqrfa ellstkfkyr yegkitnyfh ktlahvpeii erdgsigawa
      961 segnesgnkl frrfrkmnar qskcyemedv lkhhwlytsk ylqkfmnahn alktsgftmn
     1021 pqaslgdplg iedslesqds mef
//
LOCUS       XP_054225566             527 aa            linear   PRI 05-AUG-2025
DEFINITION  V(D)J recombination-activating protein 2 isoform X1 [Homo sapiens].
ACCESSION   XP_054225566
VERSION     XP_054225566.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369591.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..527
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..527
                     /product="V(D)J recombination-activating protein 2 isoform
                     X1"
                     /calculated_mol_wt=59110
     Region          51..389
                     /region_name="RAG2"
                     /note="Recombination activating protein 2; pfam03089"
                     /db_xref="CDD:427128"
     Region          414..491
                     /region_name="RAG2_PHD"
                     /note="RAG2 PHD domain; pfam13341"
                     /db_xref="CDD:404256"
     Site            order(418,442..446,453,476)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277044"
     CDS             1..527
                     /gene="RAG2"
                     /gene_synonym="RAG-2"
                     /coded_by="XM_054369591.1:1163..2746"
                     /db_xref="GeneID:5897"
                     /db_xref="HGNC:HGNC:9832"
                     /db_xref="MIM:179616"
ORIGIN      
        1 mslqmvtvsn nialiqpgfs lmnfdgqvff fgqkgwpkrs cptgvfhldv khnhvklkpt
       61 ifskdscylp plrypatctf kgslesekhq yiihggktpn nevsdkiyvm sivcknnkkv
      121 tfrctekdlv gdvpearygh sinvvysrgk smgvlfggrs ympsthrtte kwnsvadclp
      181 cvflvdfefg catsyilpel qdglsfhvsi akndtiyilg ghslannirp anlyrirvdl
      241 plgspavnct vlpggisvss ailtqtnnde fvivggyqle nqkrmicnii slednkieir
      301 emetpdwtpd ikhskiwfgs nmgngtvflg ipgdnkqvvs egfyfymlkc aeddtneeqt
      361 tftnsqtste dpgdstpfed seefcfsaea nsfdgddefd tyneddeede setgywitcc
      421 ptcdvdintw vpfystelnk pamiycshgd ghwvhaqcmd laertlihls agsnkyycne
      481 hveiaralht pqrvlplkkp pmkslrkkgs gkiltpakks flrrlfd
//
LOCUS       XP_054225570             504 aa            linear   PRI 05-AUG-2025
DEFINITION  single Ig IL-1-related receptor isoform X1 [Homo sapiens].
ACCESSION   XP_054225570
VERSION     XP_054225570.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369595.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..504
                     /product="single Ig IL-1-related receptor isoform X1"
                     /calculated_mol_wt=55090
     Region          9..>66
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          28..32
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          46..50
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          80..87
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          95..100
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          168..311
                     /region_name="TIR"
                     /note="TIR domain; pfam01582"
                     /db_xref="CDD:396246"
     CDS             1..504
                     /gene="SIGIRR"
                     /gene_synonym="IL-1R8; TIR8"
                     /coded_by="XM_054369595.1:258..1772"
                     /db_xref="GeneID:59307"
                     /db_xref="HGNC:HGNC:30575"
                     /db_xref="MIM:605478"
ORIGIN      
        1 mpgvcdrapd flspsedqvl rpalgssval nctawvvsgp hcslpsvqwl kdglplgigg
       61 hyslheyswv kanlsevlvs svlgvnvtst evygaftcsi qnisfssftl qragptshva
      121 avlasllvll alllaallyv kcrlnvllwy qdaygevein dgklydayvs ysdcpedrkf
      181 vnfilkpqle rrrgyklfld drdllpraep sadllvnlsr crrlivvlsd aflsrawcsh
      241 sfreglcrll eltrrpifit fegqrrdpah palrllrqhr hlvtlllwrp gsvtpssdfw
      301 kevqlalprk vqyrpvegdp qtqlqddkdp mlilrgrvpe graldsevdp dpegdlgmpa
      361 qphsptgeaq hraewgqaqg tgpggapgve dssrhreplh glcpggarps vclgtswasq
      421 aitaggeqgq plavglgqgc gwppqasrsp hprcpgaclw raisstahqw glagrepeqr
      481 sgrlgsrlak lqcphrlllp gvqg
//
LOCUS       XP_054225571             504 aa            linear   PRI 05-AUG-2025
DEFINITION  single Ig IL-1-related receptor isoform X1 [Homo sapiens].
ACCESSION   XP_054225571
VERSION     XP_054225571.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369596.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..504
                     /product="single Ig IL-1-related receptor isoform X1"
                     /calculated_mol_wt=55090
     Region          9..>66
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          28..32
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          46..50
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          80..87
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          95..100
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          168..311
                     /region_name="TIR"
                     /note="TIR domain; pfam01582"
                     /db_xref="CDD:396246"
     CDS             1..504
                     /gene="SIGIRR"
                     /gene_synonym="IL-1R8; TIR8"
                     /coded_by="XM_054369596.1:227..1741"
                     /db_xref="GeneID:59307"
                     /db_xref="HGNC:HGNC:30575"
                     /db_xref="MIM:605478"
ORIGIN      
        1 mpgvcdrapd flspsedqvl rpalgssval nctawvvsgp hcslpsvqwl kdglplgigg
       61 hyslheyswv kanlsevlvs svlgvnvtst evygaftcsi qnisfssftl qragptshva
      121 avlasllvll alllaallyv kcrlnvllwy qdaygevein dgklydayvs ysdcpedrkf
      181 vnfilkpqle rrrgyklfld drdllpraep sadllvnlsr crrlivvlsd aflsrawcsh
      241 sfreglcrll eltrrpifit fegqrrdpah palrllrqhr hlvtlllwrp gsvtpssdfw
      301 kevqlalprk vqyrpvegdp qtqlqddkdp mlilrgrvpe graldsevdp dpegdlgmpa
      361 qphsptgeaq hraewgqaqg tgpggapgve dssrhreplh glcpggarps vclgtswasq
      421 aitaggeqgq plavglgqgc gwppqasrsp hprcpgaclw raisstahqw glagrepeqr
      481 sgrlgsrlak lqcphrlllp gvqg
//
LOCUS       XP_054225572             479 aa            linear   PRI 05-AUG-2025
DEFINITION  single Ig IL-1-related receptor isoform X2 [Homo sapiens].
ACCESSION   XP_054225572
VERSION     XP_054225572.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369597.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..479
                     /product="single Ig IL-1-related receptor isoform X2"
                     /calculated_mol_wt=52440
     Region          9..>66
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          28..32
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          46..50
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          80..87
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          95..100
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          168..311
                     /region_name="TIR"
                     /note="TIR domain; pfam01582"
                     /db_xref="CDD:396246"
     CDS             1..479
                     /gene="SIGIRR"
                     /gene_synonym="IL-1R8; TIR8"
                     /coded_by="XM_054369597.1:258..1697"
                     /db_xref="GeneID:59307"
                     /db_xref="HGNC:HGNC:30575"
                     /db_xref="MIM:605478"
ORIGIN      
        1 mpgvcdrapd flspsedqvl rpalgssval nctawvvsgp hcslpsvqwl kdglplgigg
       61 hyslheyswv kanlsevlvs svlgvnvtst evygaftcsi qnisfssftl qragptshva
      121 avlasllvll alllaallyv kcrlnvllwy qdaygevein dgklydayvs ysdcpedrkf
      181 vnfilkpqle rrrgyklfld drdllpraep sadllvnlsr crrlivvlsd aflsrawcsh
      241 sfreglcrll eltrrpifit fegqrrdpah palrllrqhr hlvtlllwrp gsvtpssdfw
      301 kevqlalprk vqyrpvegdp qtqlqddkdp mlilrgrvpe graldsevdp dpegdlgmpa
      361 qphsptgeaq hraewgqaqg tgpggapgve dssrhreplh glcpggarps vclgtswasq
      421 aitaggvrgp vfgepsapph tsgvslgesr ssevdvsdlg srnysartdf yclvskddm
//
LOCUS       XP_054225573             479 aa            linear   PRI 05-AUG-2025
DEFINITION  single Ig IL-1-related receptor isoform X2 [Homo sapiens].
ACCESSION   XP_054225573
VERSION     XP_054225573.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369598.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..479
                     /product="single Ig IL-1-related receptor isoform X2"
                     /calculated_mol_wt=52440
     Region          9..>66
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          28..32
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          46..50
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          80..87
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          95..100
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          168..311
                     /region_name="TIR"
                     /note="TIR domain; pfam01582"
                     /db_xref="CDD:396246"
     CDS             1..479
                     /gene="SIGIRR"
                     /gene_synonym="IL-1R8; TIR8"
                     /coded_by="XM_054369598.1:227..1666"
                     /db_xref="GeneID:59307"
                     /db_xref="HGNC:HGNC:30575"
                     /db_xref="MIM:605478"
ORIGIN      
        1 mpgvcdrapd flspsedqvl rpalgssval nctawvvsgp hcslpsvqwl kdglplgigg
       61 hyslheyswv kanlsevlvs svlgvnvtst evygaftcsi qnisfssftl qragptshva
      121 avlasllvll alllaallyv kcrlnvllwy qdaygevein dgklydayvs ysdcpedrkf
      181 vnfilkpqle rrrgyklfld drdllpraep sadllvnlsr crrlivvlsd aflsrawcsh
      241 sfreglcrll eltrrpifit fegqrrdpah palrllrqhr hlvtlllwrp gsvtpssdfw
      301 kevqlalprk vqyrpvegdp qtqlqddkdp mlilrgrvpe graldsevdp dpegdlgmpa
      361 qphsptgeaq hraewgqaqg tgpggapgve dssrhreplh glcpggarps vclgtswasq
      421 aitaggvrgp vfgepsapph tsgvslgesr ssevdvsdlg srnysartdf yclvskddm
//
LOCUS       XP_054225574             281 aa            linear   PRI 05-AUG-2025
DEFINITION  single Ig IL-1-related receptor isoform X3 [Homo sapiens].
ACCESSION   XP_054225574
VERSION     XP_054225574.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369599.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..281
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..281
                     /product="single Ig IL-1-related receptor isoform X3"
                     /calculated_mol_wt=31219
     Region          8..102
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          28..32
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          46..50
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          80..87
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          95..100
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          168..>238
                     /region_name="TIR"
                     /note="TIR domain; pfam01582"
                     /db_xref="CDD:396246"
     CDS             1..281
                     /gene="SIGIRR"
                     /gene_synonym="IL-1R8; TIR8"
                     /coded_by="XM_054369599.1:258..1103"
                     /db_xref="GeneID:59307"
                     /db_xref="HGNC:HGNC:30575"
                     /db_xref="MIM:605478"
ORIGIN      
        1 mpgvcdrapd flspsedqvl rpalgssval nctawvvsgp hcslpsvqwl kdglplgigg
       61 hyslheyswv kanlsevlvs svlgvnvtst evygaftcsi qnisfssftl qragptshva
      121 avlasllvll alllaallyv kcrlnvllwy qdaygevein dgklydayvs ysdcpedrkf
      181 vnfilkpqle rrrgyklfld drdllpraep sadllvnlsr crrlivvlsd aflsrawcsh
      241 sfrllppifg kkcswrcrgr cstglwketp rrscrttrtp c
//
LOCUS       XP_054225576             237 aa            linear   PRI 05-AUG-2025
DEFINITION  radixin isoform X2 [Homo sapiens].
ACCESSION   XP_054225576
VERSION     XP_054225576.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369601.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..237
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..237
                     /product="radixin isoform X2"
                     /calculated_mol_wt=27213
     Region          <18..110
                     /region_name="ERM_helical"
                     /note="Ezrin/radixin/moesin, alpha-helical domain;
                     pfam20492"
                     /db_xref="CDD:466641"
     Region          161..237
                     /region_name="ERM_C"
                     /note="Ezrin/radixin/moesin family C terminal; pfam00769"
                     /db_xref="CDD:459932"
     CDS             1..237
                     /gene="RDX"
                     /gene_synonym="DFNB24"
                     /coded_by="XM_054369601.1:369..1082"
                     /db_xref="GeneID:5962"
                     /db_xref="HGNC:HGNC:9944"
                     /db_xref="MIM:179410"
ORIGIN      
        1 mrmiginhcw geytyfiele eqtrkaleld qerkrakeea erlekerraa eeaksaiakq
       61 aadqmknqeq laaelaefta kialleeakk kkeeeatewq hkafaaqedl ektkeelktv
      121 msappppppp pvippteneh dehdennaea saelsnegvm nhrseeervt etqknervkk
      181 qlqalssela qardetkktq ndvlhaenvk agrdkyktlr qirqgntkqr idefeam
//
LOCUS       XP_054225577             520 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor p65 isoform X1 [Homo sapiens].
ACCESSION   XP_054225577
VERSION     XP_054225577.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369602.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..520
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..520
                     /product="transcription factor p65 isoform X1"
                     /calculated_mol_wt=56634
     Region          1..156
                     /region_name="RHD-n"
                     /note="N-terminal sub-domain of the Rel homology domain
                     (RHD); cl08275"
                     /db_xref="CDD:447596"
     Site            order(2,4..5,7..8,10..13,89,91..92,156)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143640"
     Region          163..259
                     /region_name="IPT_NFkappaB"
                     /note="IPT domain of the transcription factor NFkappaB and
                     related transcription factors. NFkappaB is considered a
                     central regulator of stress responses, activated by
                     different stressful conditions, including physical stress,
                     oxidative stress, and exposure to...; cd01177"
                     /db_xref="CDD:238582"
     Site            order(164,166..168,170..172,207..209,222,234,253,256,258)
                     /site_type="other"
                     /note="ankyrin protein binding site [polypeptide binding]"
                     /db_xref="CDD:238582"
     Site            order(166..167,169,182,184,186,214..215,218,220)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:238582"
     Site            order(187,189,215..216)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238582"
     CDS             1..520
                     /gene="RELA"
                     /gene_synonym="AIF3BL3; CMCU; NFKB3; p65"
                     /coded_by="XM_054369602.1:112..1674"
                     /db_xref="GeneID:5970"
                     /db_xref="HGNC:HGNC:9955"
                     /db_xref="MIM:164014"
ORIGIN      
        1 mrfrykcegr sagsipgers tdttkthpti kingytgpgt vrislvtkdp phrphphelv
       61 gkdcrdgfye aelcpdrcih sfqnlgiqcv kkrdleqais qriqtnnnpf qvpieeqrgd
      121 ydlnavrlcf qvtvrdpsgr plrlppvlsh pifdnrapnt aelkicrvnr nsgsclggde
      181 ifllcdkvqk edievyftgp gweargsfsq advhrqvaiv frtppyadps lqapvrvsmq
      241 lrrpsdrels epmefqylpd tddrhrieek rkrtyetfks imkkspfsgp tdprppprri
      301 avpsrssasv pkpapqpypf tsslstinyd efptmvfpsg qisqasalap appqvlpqap
      361 apapapamvs alaqapapvp vlapgppqav appapkptqa gegtlseall qlqfddedlg
      421 allgnstdpa vftdlasvdn sefqqllnqg ipvaphttep mlmeypeait rlvtgaqrpp
      481 dpapaplgap glpngllsgd edfssiadmd fsallsqiss
//
LOCUS       XP_054225578             156 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 90B, mitochondrial isoform X1
            [Homo sapiens].
ACCESSION   XP_054225578
VERSION     XP_054225578.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369603.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..156
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..156
                     /product="coiled-coil domain-containing protein 90B,
                     mitochondrial isoform X1"
                     /calculated_mol_wt=18311
     Region          <10..155
                     /region_name="CCDC90-like"
                     /note="Coiled-coil domain-containing protein 90-like;
                     pfam07798"
                     /db_xref="CDD:462268"
     CDS             1..156
                     /gene="CCDC90B"
                     /gene_synonym="MDS011; MDS025"
                     /coded_by="XM_054369603.1:602..1072"
                     /db_xref="GeneID:60492"
                     /db_xref="HGNC:HGNC:28108"
                     /db_xref="MIM:620753"
ORIGIN      
        1 mhwfrtwklm eitvqqlmah ldairkdmvi leksefanlr aenekmkiel dqvkqqlmhe
       61 tsriradnkl dinlersrvt dmftdqekql mettteftkk dtqtksiise tsnkidaeia
      121 slktlmesnk letirylaas vftclaialg fyrfwk
//
LOCUS       XP_054225579             456 aa            linear   PRI 05-AUG-2025
DEFINITION  ribonuclease inhibitor isoform X1 [Homo sapiens].
ACCESSION   XP_054225579
VERSION     XP_054225579.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369604.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..456
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..456
                     /product="ribonuclease inhibitor isoform X1"
                     /calculated_mol_wt=49286
     Region          1..320
                     /region_name="LRR_RI"
                     /note="Leucine-rich repeats (LRRs), ribonuclease inhibitor
                     (RI)-like subfamily. LRRs are 20-29 residue sequence
                     motifs present in many proteins that participate in
                     protein-protein interactions and have different functions
                     and cellular locations. LRRs correspond...; cd00116"
                     /db_xref="CDD:238064"
     Region          2..24
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            order(3,5,8,10,25,28,30,33,35,53,56,58,61,63,82,85,87,90,
                     92,110,113,115,118,120,139,142,144,147,149,167,170,172,
                     175,177,196,199,201,204,206,224,227,229,232,234,253,256,
                     258,261,263,281,284,286,289,291,310,313,315,318,320)
                     /site_type="active"
                     /note="Leucine-rich repeats [active]"
                     /db_xref="CDD:238064"
     Region          25..52
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            order(31..32,89,146,174,231,257,259,285,314)
                     /site_type="other"
                     /note="Substrate binding site [chemical binding]"
                     /db_xref="CDD:238064"
     Region          53..81
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          82..109
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          110..138
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          139..166
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          167..195
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          196..223
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          <223..425
                     /region_name="RNA1"
                     /note="Ran GTPase-activating protein (RanGAP) involved in
                     mRNA processing and transport [Translation, ribosomal
                     structure and biogenesis]; COG5238"
                     /db_xref="CDD:444072"
     Region          224..252
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          253..273
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          281..309
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          310..333
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          338..362
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          367..394
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     CDS             1..456
                     /gene="RNH1"
                     /gene_synonym="IIAE12; RAI; RNH"
                     /coded_by="XM_054369604.1:426..1796"
                     /db_xref="GeneID:6050"
                     /db_xref="HGNC:HGNC:10074"
                     /db_xref="MIM:173320"
ORIGIN      
        1 msldiqceel sdarwaellp llqqcqvvrl ddcgltearc kdissalrvn palaelnlrs
       61 nelgdvgvhc vlqglqtpsc kiqklslqnc cltgagcgvl sstlrtlptl qelhlsdnll
      121 gdaglqllce glldpqcrle klqleycsls aasceplasv lrakpdfkel tvsnndinea
      181 gvrvlcqglk dspcqlealk lescgvtsdn crdlcgivas kaslrelalg snklgdvgma
      241 elcpgllhps srlrtlwiwe cgitakgcgd lcrvlrakes lkelslagne lgdegarllc
      301 etllepgcql eslwvkscsf taaccshfss vlaqnrflle lqisnnrled agvrelcqgl
      361 gqpgsvlrvl wladcdvsds scsslaatll anhslreldl snnclgdagi lqlvesvrqp
      421 gclleqlvly diywseemed rlqalekdkp slrvis
//
LOCUS       XP_054225580             456 aa            linear   PRI 05-AUG-2025
DEFINITION  ribonuclease inhibitor isoform X1 [Homo sapiens].
ACCESSION   XP_054225580
VERSION     XP_054225580.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369605.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..456
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..456
                     /product="ribonuclease inhibitor isoform X1"
                     /calculated_mol_wt=49286
     Region          1..320
                     /region_name="LRR_RI"
                     /note="Leucine-rich repeats (LRRs), ribonuclease inhibitor
                     (RI)-like subfamily. LRRs are 20-29 residue sequence
                     motifs present in many proteins that participate in
                     protein-protein interactions and have different functions
                     and cellular locations. LRRs correspond...; cd00116"
                     /db_xref="CDD:238064"
     Region          2..24
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            order(3,5,8,10,25,28,30,33,35,53,56,58,61,63,82,85,87,90,
                     92,110,113,115,118,120,139,142,144,147,149,167,170,172,
                     175,177,196,199,201,204,206,224,227,229,232,234,253,256,
                     258,261,263,281,284,286,289,291,310,313,315,318,320)
                     /site_type="active"
                     /note="Leucine-rich repeats [active]"
                     /db_xref="CDD:238064"
     Region          25..52
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            order(31..32,89,146,174,231,257,259,285,314)
                     /site_type="other"
                     /note="Substrate binding site [chemical binding]"
                     /db_xref="CDD:238064"
     Region          53..81
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          82..109
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          110..138
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          139..166
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          167..195
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          196..223
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          <223..425
                     /region_name="RNA1"
                     /note="Ran GTPase-activating protein (RanGAP) involved in
                     mRNA processing and transport [Translation, ribosomal
                     structure and biogenesis]; COG5238"
                     /db_xref="CDD:444072"
     Region          224..252
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          253..273
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          281..309
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          310..333
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          338..362
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          367..394
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     CDS             1..456
                     /gene="RNH1"
                     /gene_synonym="IIAE12; RAI; RNH"
                     /coded_by="XM_054369605.1:475..1845"
                     /db_xref="GeneID:6050"
                     /db_xref="HGNC:HGNC:10074"
                     /db_xref="MIM:173320"
ORIGIN      
        1 msldiqceel sdarwaellp llqqcqvvrl ddcgltearc kdissalrvn palaelnlrs
       61 nelgdvgvhc vlqglqtpsc kiqklslqnc cltgagcgvl sstlrtlptl qelhlsdnll
      121 gdaglqllce glldpqcrle klqleycsls aasceplasv lrakpdfkel tvsnndinea
      181 gvrvlcqglk dspcqlealk lescgvtsdn crdlcgivas kaslrelalg snklgdvgma
      241 elcpgllhps srlrtlwiwe cgitakgcgd lcrvlrakes lkelslagne lgdegarllc
      301 etllepgcql eslwvkscsf taaccshfss vlaqnrflle lqisnnrled agvrelcqgl
      361 gqpgsvlrvl wladcdvsds scsslaatll anhslreldl snnclgdagi lqlvesvrqp
      421 gclleqlvly diywseemed rlqalekdkp slrvis
//
LOCUS       XP_054225581             456 aa            linear   PRI 05-AUG-2025
DEFINITION  ribonuclease inhibitor isoform X1 [Homo sapiens].
ACCESSION   XP_054225581
VERSION     XP_054225581.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369606.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..456
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..456
                     /product="ribonuclease inhibitor isoform X1"
                     /calculated_mol_wt=49286
     Region          1..320
                     /region_name="LRR_RI"
                     /note="Leucine-rich repeats (LRRs), ribonuclease inhibitor
                     (RI)-like subfamily. LRRs are 20-29 residue sequence
                     motifs present in many proteins that participate in
                     protein-protein interactions and have different functions
                     and cellular locations. LRRs correspond...; cd00116"
                     /db_xref="CDD:238064"
     Region          2..24
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            order(3,5,8,10,25,28,30,33,35,53,56,58,61,63,82,85,87,90,
                     92,110,113,115,118,120,139,142,144,147,149,167,170,172,
                     175,177,196,199,201,204,206,224,227,229,232,234,253,256,
                     258,261,263,281,284,286,289,291,310,313,315,318,320)
                     /site_type="active"
                     /note="Leucine-rich repeats [active]"
                     /db_xref="CDD:238064"
     Region          25..52
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            order(31..32,89,146,174,231,257,259,285,314)
                     /site_type="other"
                     /note="Substrate binding site [chemical binding]"
                     /db_xref="CDD:238064"
     Region          53..81
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          82..109
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          110..138
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          139..166
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          167..195
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          196..223
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          <223..425
                     /region_name="RNA1"
                     /note="Ran GTPase-activating protein (RanGAP) involved in
                     mRNA processing and transport [Translation, ribosomal
                     structure and biogenesis]; COG5238"
                     /db_xref="CDD:444072"
     Region          224..252
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          253..273
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          281..309
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          310..333
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          338..362
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          367..394
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     CDS             1..456
                     /gene="RNH1"
                     /gene_synonym="IIAE12; RAI; RNH"
                     /coded_by="XM_054369606.1:358..1728"
                     /db_xref="GeneID:6050"
                     /db_xref="HGNC:HGNC:10074"
                     /db_xref="MIM:173320"
ORIGIN      
        1 msldiqceel sdarwaellp llqqcqvvrl ddcgltearc kdissalrvn palaelnlrs
       61 nelgdvgvhc vlqglqtpsc kiqklslqnc cltgagcgvl sstlrtlptl qelhlsdnll
      121 gdaglqllce glldpqcrle klqleycsls aasceplasv lrakpdfkel tvsnndinea
      181 gvrvlcqglk dspcqlealk lescgvtsdn crdlcgivas kaslrelalg snklgdvgma
      241 elcpgllhps srlrtlwiwe cgitakgcgd lcrvlrakes lkelslagne lgdegarllc
      301 etllepgcql eslwvkscsf taaccshfss vlaqnrflle lqisnnrled agvrelcqgl
      361 gqpgsvlrvl wladcdvsds scsslaatll anhslreldl snnclgdagi lqlvesvrqp
      421 gclleqlvly diywseemed rlqalekdkp slrvis
//
LOCUS       XP_054225582             456 aa            linear   PRI 05-AUG-2025
DEFINITION  ribonuclease inhibitor isoform X1 [Homo sapiens].
ACCESSION   XP_054225582
VERSION     XP_054225582.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369607.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..456
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..456
                     /product="ribonuclease inhibitor isoform X1"
                     /calculated_mol_wt=49286
     Region          1..320
                     /region_name="LRR_RI"
                     /note="Leucine-rich repeats (LRRs), ribonuclease inhibitor
                     (RI)-like subfamily. LRRs are 20-29 residue sequence
                     motifs present in many proteins that participate in
                     protein-protein interactions and have different functions
                     and cellular locations. LRRs correspond...; cd00116"
                     /db_xref="CDD:238064"
     Region          2..24
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            order(3,5,8,10,25,28,30,33,35,53,56,58,61,63,82,85,87,90,
                     92,110,113,115,118,120,139,142,144,147,149,167,170,172,
                     175,177,196,199,201,204,206,224,227,229,232,234,253,256,
                     258,261,263,281,284,286,289,291,310,313,315,318,320)
                     /site_type="active"
                     /note="Leucine-rich repeats [active]"
                     /db_xref="CDD:238064"
     Region          25..52
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            order(31..32,89,146,174,231,257,259,285,314)
                     /site_type="other"
                     /note="Substrate binding site [chemical binding]"
                     /db_xref="CDD:238064"
     Region          53..81
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          82..109
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          110..138
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          139..166
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          167..195
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          196..223
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          <223..425
                     /region_name="RNA1"
                     /note="Ran GTPase-activating protein (RanGAP) involved in
                     mRNA processing and transport [Translation, ribosomal
                     structure and biogenesis]; COG5238"
                     /db_xref="CDD:444072"
     Region          224..252
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          253..273
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          281..309
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          310..333
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          338..362
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          367..394
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     CDS             1..456
                     /gene="RNH1"
                     /gene_synonym="IIAE12; RAI; RNH"
                     /coded_by="XM_054369607.1:407..1777"
                     /db_xref="GeneID:6050"
                     /db_xref="HGNC:HGNC:10074"
                     /db_xref="MIM:173320"
ORIGIN      
        1 msldiqceel sdarwaellp llqqcqvvrl ddcgltearc kdissalrvn palaelnlrs
       61 nelgdvgvhc vlqglqtpsc kiqklslqnc cltgagcgvl sstlrtlptl qelhlsdnll
      121 gdaglqllce glldpqcrle klqleycsls aasceplasv lrakpdfkel tvsnndinea
      181 gvrvlcqglk dspcqlealk lescgvtsdn crdlcgivas kaslrelalg snklgdvgma
      241 elcpgllhps srlrtlwiwe cgitakgcgd lcrvlrakes lkelslagne lgdegarllc
      301 etllepgcql eslwvkscsf taaccshfss vlaqnrflle lqisnnrled agvrelcqgl
      361 gqpgsvlrvl wladcdvsds scsslaatll anhslreldl snnclgdagi lqlvesvrqp
      421 gclleqlvly diywseemed rlqalekdkp slrvis
//
LOCUS       XP_054225583             456 aa            linear   PRI 05-AUG-2025
DEFINITION  ribonuclease inhibitor isoform X1 [Homo sapiens].
ACCESSION   XP_054225583
VERSION     XP_054225583.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369608.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..456
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..456
                     /product="ribonuclease inhibitor isoform X1"
                     /calculated_mol_wt=49286
     Region          1..320
                     /region_name="LRR_RI"
                     /note="Leucine-rich repeats (LRRs), ribonuclease inhibitor
                     (RI)-like subfamily. LRRs are 20-29 residue sequence
                     motifs present in many proteins that participate in
                     protein-protein interactions and have different functions
                     and cellular locations. LRRs correspond...; cd00116"
                     /db_xref="CDD:238064"
     Region          2..24
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            order(3,5,8,10,25,28,30,33,35,53,56,58,61,63,82,85,87,90,
                     92,110,113,115,118,120,139,142,144,147,149,167,170,172,
                     175,177,196,199,201,204,206,224,227,229,232,234,253,256,
                     258,261,263,281,284,286,289,291,310,313,315,318,320)
                     /site_type="active"
                     /note="Leucine-rich repeats [active]"
                     /db_xref="CDD:238064"
     Region          25..52
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            order(31..32,89,146,174,231,257,259,285,314)
                     /site_type="other"
                     /note="Substrate binding site [chemical binding]"
                     /db_xref="CDD:238064"
     Region          53..81
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          82..109
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          110..138
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          139..166
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          167..195
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          196..223
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          <223..425
                     /region_name="RNA1"
                     /note="Ran GTPase-activating protein (RanGAP) involved in
                     mRNA processing and transport [Translation, ribosomal
                     structure and biogenesis]; COG5238"
                     /db_xref="CDD:444072"
     Region          224..252
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          253..273
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          281..309
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          310..333
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          338..362
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          367..394
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     CDS             1..456
                     /gene="RNH1"
                     /gene_synonym="IIAE12; RAI; RNH"
                     /coded_by="XM_054369608.1:522..1892"
                     /db_xref="GeneID:6050"
                     /db_xref="HGNC:HGNC:10074"
                     /db_xref="MIM:173320"
ORIGIN      
        1 msldiqceel sdarwaellp llqqcqvvrl ddcgltearc kdissalrvn palaelnlrs
       61 nelgdvgvhc vlqglqtpsc kiqklslqnc cltgagcgvl sstlrtlptl qelhlsdnll
      121 gdaglqllce glldpqcrle klqleycsls aasceplasv lrakpdfkel tvsnndinea
      181 gvrvlcqglk dspcqlealk lescgvtsdn crdlcgivas kaslrelalg snklgdvgma
      241 elcpgllhps srlrtlwiwe cgitakgcgd lcrvlrakes lkelslagne lgdegarllc
      301 etllepgcql eslwvkscsf taaccshfss vlaqnrflle lqisnnrled agvrelcqgl
      361 gqpgsvlrvl wladcdvsds scsslaatll anhslreldl snnclgdagi lqlvesvrqp
      421 gclleqlvly diywseemed rlqalekdkp slrvis
//
LOCUS       XP_054225584             456 aa            linear   PRI 05-AUG-2025
DEFINITION  ribonuclease inhibitor isoform X1 [Homo sapiens].
ACCESSION   XP_054225584
VERSION     XP_054225584.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369609.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..456
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..456
                     /product="ribonuclease inhibitor isoform X1"
                     /calculated_mol_wt=49286
     Region          1..320
                     /region_name="LRR_RI"
                     /note="Leucine-rich repeats (LRRs), ribonuclease inhibitor
                     (RI)-like subfamily. LRRs are 20-29 residue sequence
                     motifs present in many proteins that participate in
                     protein-protein interactions and have different functions
                     and cellular locations. LRRs correspond...; cd00116"
                     /db_xref="CDD:238064"
     Region          2..24
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            order(3,5,8,10,25,28,30,33,35,53,56,58,61,63,82,85,87,90,
                     92,110,113,115,118,120,139,142,144,147,149,167,170,172,
                     175,177,196,199,201,204,206,224,227,229,232,234,253,256,
                     258,261,263,281,284,286,289,291,310,313,315,318,320)
                     /site_type="active"
                     /note="Leucine-rich repeats [active]"
                     /db_xref="CDD:238064"
     Region          25..52
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            order(31..32,89,146,174,231,257,259,285,314)
                     /site_type="other"
                     /note="Substrate binding site [chemical binding]"
                     /db_xref="CDD:238064"
     Region          53..81
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          82..109
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          110..138
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          139..166
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          167..195
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          196..223
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          <223..425
                     /region_name="RNA1"
                     /note="Ran GTPase-activating protein (RanGAP) involved in
                     mRNA processing and transport [Translation, ribosomal
                     structure and biogenesis]; COG5238"
                     /db_xref="CDD:444072"
     Region          224..252
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          253..273
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          281..309
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          310..333
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          338..362
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          367..394
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     CDS             1..456
                     /gene="RNH1"
                     /gene_synonym="IIAE12; RAI; RNH"
                     /coded_by="XM_054369609.1:490..1860"
                     /db_xref="GeneID:6050"
                     /db_xref="HGNC:HGNC:10074"
                     /db_xref="MIM:173320"
ORIGIN      
        1 msldiqceel sdarwaellp llqqcqvvrl ddcgltearc kdissalrvn palaelnlrs
       61 nelgdvgvhc vlqglqtpsc kiqklslqnc cltgagcgvl sstlrtlptl qelhlsdnll
      121 gdaglqllce glldpqcrle klqleycsls aasceplasv lrakpdfkel tvsnndinea
      181 gvrvlcqglk dspcqlealk lescgvtsdn crdlcgivas kaslrelalg snklgdvgma
      241 elcpgllhps srlrtlwiwe cgitakgcgd lcrvlrakes lkelslagne lgdegarllc
      301 etllepgcql eslwvkscsf taaccshfss vlaqnrflle lqisnnrled agvrelcqgl
      361 gqpgsvlrvl wladcdvsds scsslaatll anhslreldl snnclgdagi lqlvesvrqp
      421 gclleqlvly diywseemed rlqalekdkp slrvis
//
LOCUS       XP_054225585             456 aa            linear   PRI 05-AUG-2025
DEFINITION  ribonuclease inhibitor isoform X1 [Homo sapiens].
ACCESSION   XP_054225585
VERSION     XP_054225585.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369610.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..456
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..456
                     /product="ribonuclease inhibitor isoform X1"
                     /calculated_mol_wt=49286
     Region          1..320
                     /region_name="LRR_RI"
                     /note="Leucine-rich repeats (LRRs), ribonuclease inhibitor
                     (RI)-like subfamily. LRRs are 20-29 residue sequence
                     motifs present in many proteins that participate in
                     protein-protein interactions and have different functions
                     and cellular locations. LRRs correspond...; cd00116"
                     /db_xref="CDD:238064"
     Region          2..24
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            order(3,5,8,10,25,28,30,33,35,53,56,58,61,63,82,85,87,90,
                     92,110,113,115,118,120,139,142,144,147,149,167,170,172,
                     175,177,196,199,201,204,206,224,227,229,232,234,253,256,
                     258,261,263,281,284,286,289,291,310,313,315,318,320)
                     /site_type="active"
                     /note="Leucine-rich repeats [active]"
                     /db_xref="CDD:238064"
     Region          25..52
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            order(31..32,89,146,174,231,257,259,285,314)
                     /site_type="other"
                     /note="Substrate binding site [chemical binding]"
                     /db_xref="CDD:238064"
     Region          53..81
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          82..109
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          110..138
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          139..166
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          167..195
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          196..223
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          <223..425
                     /region_name="RNA1"
                     /note="Ran GTPase-activating protein (RanGAP) involved in
                     mRNA processing and transport [Translation, ribosomal
                     structure and biogenesis]; COG5238"
                     /db_xref="CDD:444072"
     Region          224..252
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          253..273
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          281..309
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          310..333
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          338..362
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          367..394
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     CDS             1..456
                     /gene="RNH1"
                     /gene_synonym="IIAE12; RAI; RNH"
                     /coded_by="XM_054369610.1:396..1766"
                     /db_xref="GeneID:6050"
                     /db_xref="HGNC:HGNC:10074"
                     /db_xref="MIM:173320"
ORIGIN      
        1 msldiqceel sdarwaellp llqqcqvvrl ddcgltearc kdissalrvn palaelnlrs
       61 nelgdvgvhc vlqglqtpsc kiqklslqnc cltgagcgvl sstlrtlptl qelhlsdnll
      121 gdaglqllce glldpqcrle klqleycsls aasceplasv lrakpdfkel tvsnndinea
      181 gvrvlcqglk dspcqlealk lescgvtsdn crdlcgivas kaslrelalg snklgdvgma
      241 elcpgllhps srlrtlwiwe cgitakgcgd lcrvlrakes lkelslagne lgdegarllc
      301 etllepgcql eslwvkscsf taaccshfss vlaqnrflle lqisnnrled agvrelcqgl
      361 gqpgsvlrvl wladcdvsds scsslaatll anhslreldl snnclgdagi lqlvesvrqp
      421 gclleqlvly diywseemed rlqalekdkp slrvis
//
LOCUS       XP_054225586             541 aa            linear   PRI 05-AUG-2025
DEFINITION  chaperone Ric-8A isoform X1 [Homo sapiens].
ACCESSION   XP_054225586
VERSION     XP_054225586.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369611.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..541
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..541
                     /product="chaperone Ric-8A isoform X1"
                     /calculated_mol_wt=60717
     Region          71..503
                     /region_name="Ric8"
                     /note="Guanine nucleotide exchange factor synembryn;
                     pfam10165"
                     /db_xref="CDD:462973"
     CDS             1..541
                     /gene="RIC8A"
                     /gene_synonym="RIC8"
                     /coded_by="XM_054369611.1:1148..2773"
                     /db_xref="GeneID:60626"
                     /db_xref="HGNC:HGNC:29550"
                     /db_xref="MIM:609146"
ORIGIN      
        1 mepravaeav etgeedvime alrsynqefs lqhsqsftfd daqqedrkrl aellvsvleq
       61 glppshrviw lqsvrilsrd rncldpftsr qslqalacya disvsegsvp esadmdvvle
      121 slkclcnlvl sspvaqmlaa earlvvklte rvglyrersf phdvqffdlr llflltalrt
      181 dvrqqlfqel kgvrlltdtl eltlgvtpeg nppptllpsq eterameilk vlfnitldsi
      241 kgevdeedaa lyrhlgtllr hcvmiatagd rteefhghav nllgnlplkc ldvlltleph
      301 gdstefmgvn mdvirallif lekrlhkthr lkesvapvls vltecarmhr parkflkaqg
      361 wpppqvlppl rdvrtrpevg emlrnklvrl mthldtdvkr vaaeflfvlc sesvprfiky
      421 tgygnaagll aarglmaggr pegqyseded tdtdeykeak asinpvtgrv eekppnpmeg
      481 mteeqkehea mklvtmfdkl srnrviqpmg msprghltsl qdamcetmeq qlssdpdsdp
      541 d
//
LOCUS       XP_054225587             241 aa            linear   PRI 05-AUG-2025
DEFINITION  large ribosomal subunit protein uL23m isoform X1 [Homo sapiens].
ACCESSION   XP_054225587
VERSION     XP_054225587.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369612.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..241
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..241
                     /product="large ribosomal subunit protein uL23m isoform
                     X1"
                     /calculated_mol_wt=26749
     Region          <42..99
                     /region_name="Ribosomal_L23"
                     /note="Ribosomal protein L23; pfam00276"
                     /db_xref="CDD:459743"
     CDS             1..241
                     /gene="MRPL23"
                     /gene_synonym="L23MRP; RPL23; RPL23L; uL23m"
                     /coded_by="XM_054369612.1:32..757"
                     /db_xref="GeneID:6150"
                     /db_xref="HGNC:HGNC:10322"
                     /db_xref="MIM:600789"
ORIGIN      
        1 marnvvyply rlggpqlrvf rtnffiqlvr pgvaqpedtv qfripmemtr vdlrnylegi
       61 ynvpvaavrt rvqhgsnkrr dhrnvrikkp dykvayvqlp sqtpskeqng qgstlcfrss
      121 cskgwstwgt rdprpawspv ggriprkags ggpanriaqd gslllnsfrs aepqgcrslg
      181 pqspggdpah tilrppsqng dcaemhacrl hpailgvhis rkkslpipra pwrrifpsgl
      241 f
//
LOCUS       XP_054225588             296 aa            linear   PRI 05-AUG-2025
DEFINITION  ribosomal protein S6 kinase beta-2 isoform X1 [Homo sapiens].
ACCESSION   XP_054225588
VERSION     XP_054225588.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369613.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..296
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..296
                     /product="ribosomal protein S6 kinase beta-2 isoform X1"
                     /calculated_mol_wt=32550
     Region          70..>259
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Site            order(73..76,79,81,97,99,132,148..151,194,198..199,201,
                     211..212)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270870"
     CDS             1..296
                     /gene="RPS6KB2"
                     /gene_synonym="KLS; p70(S6K)-beta; P70-beta; P70-beta-1;
                     P70-beta-2; p70S6Kb; S6K-beta2; S6K2; S6KB; S6Kbeta;
                     S6KI(2); SRK; STK14B"
                     /coded_by="XM_054369613.1:53..943"
                     /db_xref="GeneID:6199"
                     /db_xref="HGNC:HGNC:10437"
                     /db_xref="MIM:608939"
ORIGIN      
        1 maavfdldle teegsegege pelspadacp laelraagle pvghyeevel tetsvnvgpe
       61 rigphcfell rvlgkggygk vfqvrkvqgt nlgkiyamkv lrkakivrna kdtahtraer
      121 nilesvkhpf ivelayafqt ggklylilec lsggelfthl eregifledt acfylaeitl
      181 alghlhsqgi iyrdlkpeni mlssqghikl tdfglckesi hegavthtfc gtieymapei
      241 lvrsghnrav dwwslgalir pspqrtgrkp wirssgaswh cpptspqmpg tlsksf
//
LOCUS       XP_054225589             282 aa            linear   PRI 05-AUG-2025
DEFINITION  ribosomal protein S6 kinase beta-2 isoform X2 [Homo sapiens].
ACCESSION   XP_054225589
VERSION     XP_054225589.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369614.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..282
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..282
                     /product="ribosomal protein S6 kinase beta-2 isoform X2"
                     /calculated_mol_wt=31261
     Region          <1..192
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..282
                     /gene="RPS6KB2"
                     /gene_synonym="KLS; p70(S6K)-beta; P70-beta; P70-beta-1;
                     P70-beta-2; p70S6Kb; S6K-beta2; S6K2; S6KB; S6Kbeta;
                     S6KI(2); SRK; STK14B"
                     /coded_by="XM_054369614.1:281..1129"
                     /db_xref="GeneID:6199"
                     /db_xref="HGNC:HGNC:10437"
                     /db_xref="MIM:608939"
ORIGIN      
        1 mlssqghikl tdfglckesi hegavthtfc gtieymapei lvrsghnrav dwwslgalmy
       61 dmltgsppft aenrkktmdk iirgklalpp yltpdardlv kkflkrnpsq rigggpgdaa
      121 dvqrhpffrh mnwddllawr vdppfrpclq seedvsqfdt rftrqtpvds pddtalsesa
      181 nqaflgftyv apsvldsike gfsfqpklrs prrlnsspra pvsplkfspf egfrpspslp
      241 eptelplppl lpppppstta plpirppsgt kkskrgrgrp gr
//
LOCUS       XP_054225590             273 aa            linear   PRI 05-AUG-2025
DEFINITION  ribosomal protein S6 kinase beta-2 isoform X3 [Homo sapiens].
ACCESSION   XP_054225590
VERSION     XP_054225590.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369615.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..273
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..273
                     /product="ribosomal protein S6 kinase beta-2 isoform X3"
                     /calculated_mol_wt=29989
     Region          70..>244
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Site            order(73..76,79,81,97,99,132,148..151,194,198..199,201,
                     211..212)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270736"
     CDS             1..273
                     /gene="RPS6KB2"
                     /gene_synonym="KLS; p70(S6K)-beta; P70-beta; P70-beta-1;
                     P70-beta-2; p70S6Kb; S6K-beta2; S6K2; S6KB; S6Kbeta;
                     S6KI(2); SRK; STK14B"
                     /coded_by="XM_054369615.1:53..874"
                     /db_xref="GeneID:6199"
                     /db_xref="HGNC:HGNC:10437"
                     /db_xref="MIM:608939"
ORIGIN      
        1 maavfdldle teegsegege pelspadacp laelraagle pvghyeevel tetsvnvgpe
       61 rigphcfell rvlgkggygk vfqvrkvqgt nlgkiyamkv lrkakivrna kdtahtraer
      121 nilesvkhpf ivelayafqt ggklylilec lsggelfthl eregifledt acfylaeitl
      181 alghlhsqgi iyrdlkpeni mlssqghikl tdfglckesi hegavthtfc gtieyirpsp
      241 qrtgrkpwir ssgaswhcpp tspqmpgtls ksf
//
LOCUS       XP_054225591             146 aa            linear   PRI 05-AUG-2025
DEFINITION  p53-regulated apoptosis-inducing protein 1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225591
VERSION     XP_054225591.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369616.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..146
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..146
                     /product="p53-regulated apoptosis-inducing protein 1
                     isoform X1"
                     /calculated_mol_wt=15453
     Region          24..146
                     /region_name="TPIP1"
                     /note="p53-regulated apoptosis-inducing protein 1;
                     pfam15338"
                     /db_xref="CDD:464658"
     CDS             1..146
                     /gene="TP53AIP1"
                     /gene_synonym="P53AIP1"
                     /coded_by="XM_054369616.1:29..469"
                     /db_xref="GeneID:63970"
                     /db_xref="HGNC:HGNC:29984"
                     /db_xref="MIM:605426"
ORIGIN      
        1 mcrrrpfprt lrllggrqgl pwmgssseas frsaqascsg arrqglgrgd qnlsvmppng
       61 raqthtpgwv sdplvlgaqv hggcrgieal svssgswssa tvwiltglgl glsrpflpga
      121 tvlrdrplgs afelsydqkk aplrlq
//
LOCUS       XP_054225592             142 aa            linear   PRI 05-AUG-2025
DEFINITION  p53-regulated apoptosis-inducing protein 1 isoform X2 [Homo
            sapiens].
ACCESSION   XP_054225592
VERSION     XP_054225592.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369617.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..142
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..142
                     /product="p53-regulated apoptosis-inducing protein 1
                     isoform X2"
                     /calculated_mol_wt=15112
     Region          24..142
                     /region_name="TPIP1"
                     /note="p53-regulated apoptosis-inducing protein 1;
                     pfam15338"
                     /db_xref="CDD:464658"
     CDS             1..142
                     /gene="TP53AIP1"
                     /gene_synonym="P53AIP1"
                     /coded_by="XM_054369617.1:29..457"
                     /db_xref="GeneID:63970"
                     /db_xref="HGNC:HGNC:29984"
                     /db_xref="MIM:605426"
ORIGIN      
        1 mcrrrpfprt lrllggrqgl pwmgssseas frsaqascsg arrqglgrgd qnlsvmppng
       61 raqthtpgwv sdplvlgaqv hggcrgieal svssgswssa tvwiltglsr pflpgatvlr
      121 drplgsafel sydqkkaplr lq
//
LOCUS       XP_054225593             130 aa            linear   PRI 05-AUG-2025
DEFINITION  p53-regulated apoptosis-inducing protein 1 isoform X3 [Homo
            sapiens].
ACCESSION   XP_054225593
VERSION     XP_054225593.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369618.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..130
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..130
                     /product="p53-regulated apoptosis-inducing protein 1
                     isoform X3"
                     /calculated_mol_wt=14000
     Region          24..>70
                     /region_name="TPIP1"
                     /note="p53-regulated apoptosis-inducing protein 1;
                     pfam15338"
                     /db_xref="CDD:464658"
     CDS             1..130
                     /gene="TP53AIP1"
                     /gene_synonym="P53AIP1"
                     /coded_by="XM_054369618.1:29..421"
                     /db_xref="GeneID:63970"
                     /db_xref="HGNC:HGNC:29984"
                     /db_xref="MIM:605426"
ORIGIN      
        1 mcrrrpfprt lrllggrqgl pwmgssseas frsaqascsg arrqglgrgd qnlsvmppng
       61 raqthtpgwm glgapvtysk ksfpvanned dalgslwalr rgsllfllsq fgfhgnlsgs
      121 vitllrfqip
//
LOCUS       XP_054225594             124 aa            linear   PRI 05-AUG-2025
DEFINITION  p53-regulated apoptosis-inducing protein 1 isoform X4 [Homo
            sapiens].
ACCESSION   XP_054225594
VERSION     XP_054225594.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369619.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 4% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..124
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..124
                     /product="p53-regulated apoptosis-inducing protein 1
                     isoform X4"
                     /calculated_mol_wt=12803
     Region          2..124
                     /region_name="TPIP1"
                     /note="p53-regulated apoptosis-inducing protein 1;
                     pfam15338"
                     /db_xref="CDD:464658"
     CDS             1..124
                     /gene="TP53AIP1"
                     /gene_synonym="P53AIP1"
                     /coded_by="XM_054369619.1:4758..5132"
                     /db_xref="GeneID:63970"
                     /db_xref="HGNC:HGNC:29984"
                     /db_xref="MIM:605426"
ORIGIN      
        1 mgssseasfr saqascsgar rqglgrgdqn lsvmppngra qthtpgwvsd plvlgaqvhg
       61 gcrgiealsv ssgswssatv wiltglglgl srpflpgatv lrdrplgsaf elsydqkkap
      121 lrlq
//
LOCUS       XP_054225595             108 aa            linear   PRI 05-AUG-2025
DEFINITION  p53-regulated apoptosis-inducing protein 1 isoform X5 [Homo
            sapiens].
ACCESSION   XP_054225595
VERSION     XP_054225595.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369620.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 1% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..108
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..108
                     /product="p53-regulated apoptosis-inducing protein 1
                     isoform X5"
                     /calculated_mol_wt=11359
     Region          24..>106
                     /region_name="TPIP1"
                     /note="p53-regulated apoptosis-inducing protein 1;
                     pfam15338"
                     /db_xref="CDD:464658"
     CDS             1..108
                     /gene="TP53AIP1"
                     /gene_synonym="P53AIP1"
                     /coded_by="XM_054369620.1:29..355"
                     /db_xref="GeneID:63970"
                     /db_xref="HGNC:HGNC:29984"
                     /db_xref="MIM:605426"
ORIGIN      
        1 mcrrrpfprt lrllggrqgl pwmgssseas frsaqascsg arrqglgrgd qnlsvmppng
       61 raqthtpgwv sdplvlgaqv hggcrgieal svssgswssa tvwiltvq
//
LOCUS       XP_054225596             106 aa            linear   PRI 05-AUG-2025
DEFINITION  p53-regulated apoptosis-inducing protein 1 isoform X6 [Homo
            sapiens].
ACCESSION   XP_054225596
VERSION     XP_054225596.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369621.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..106
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..106
                     /product="p53-regulated apoptosis-inducing protein 1
                     isoform X6"
                     /calculated_mol_wt=11398
     Region          24..>70
                     /region_name="TPIP1"
                     /note="p53-regulated apoptosis-inducing protein 1;
                     pfam15338"
                     /db_xref="CDD:464658"
     CDS             1..106
                     /gene="TP53AIP1"
                     /gene_synonym="P53AIP1"
                     /coded_by="XM_054369621.1:29..349"
                     /db_xref="GeneID:63970"
                     /db_xref="HGNC:HGNC:29984"
                     /db_xref="MIM:605426"
ORIGIN      
        1 mcrrrpfprt lrllggrqgl pwmgssseas frsaqascsg arrqglgrgd qnlsvmppng
       61 raqthtpgwm glgapvtysk ksfpvanned dalgslwalr rgfqip
//
LOCUS       XP_054225597             966 aa            linear   PRI 05-AUG-2025
DEFINITION  anoctamin-3 isoform X1 [Homo sapiens].
ACCESSION   XP_054225597
VERSION     XP_054225597.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369622.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..966
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..966
                     /product="anoctamin-3 isoform X1"
                     /calculated_mol_wt=112764
     Region          157..366
                     /region_name="Anoct_dimer"
                     /note="dimerization domain of Ca+-activated
                     chloride-channel, anoctamin; pfam16178"
                     /db_xref="CDD:465044"
     Region          369..934
                     /region_name="Anoctamin"
                     /note="Calcium-activated chloride channel; pfam04547"
                     /db_xref="CDD:461349"
     CDS             1..966
                     /gene="ANO3"
                     /gene_synonym="C11orf25; DYT23; DYT24; GENX-3947; TMEM16C"
                     /coded_by="XM_054369622.1:147..3047"
                     /db_xref="GeneID:63982"
                     /db_xref="HGNC:HGNC:14004"
                     /db_xref="MIM:610110"
ORIGIN      
        1 mvhhsgsiqs fkqqkgmnis kseitketsl kpsrrslpcl aqsyaysksl sqstslfqst
       61 esesqaptsi tlistdkaeq vnteenknds vlrcsfadls dfclalgkdk dytdesehat
      121 ydrsrlindf vikdksefkt klskndmnyi assgplfkdg kkridyilvy rktniqydkr
      181 ntfeknlrae glmlekepai aspdimfiki hipwdtlcky aerlnirmpf rmqtyfrrik
      241 nwmaqnpmvl dksafpdlee sdcytgpfsr arihhfiinn kdtffsnatr srivyhmler
      301 tkyengiskv girklinngs yiaafppheg aykssqpikt hgpqnnrhll yerwarwgmw
      361 ykhqpldlir lyfgekigly fawlgwytgm lipaaivglc vffyglftmn nsqvsqeick
      421 atevfmcplc dkncslqrln dsciyakvty lfdnggtvff aifmaiwatv flefwkrrrs
      481 iltytwdlie weeeeetlrp qfeakyykme ivnpitgkpe phqpssdkvt rllvsvsgif
      541 fmislvitav fgvvvyrlvv meqfasfkwn fikqywqfat saaavcinfi iimllnlaye
      601 kiaylltnle yprtesewen sfalkmflfq fvnlnssify iafflgrfvg hpgkynklfd
      661 rwrleechps gclidlclqm gvimflkqiw nnfmelgypl iqnwwsrhki krgihdasip
      721 qwendwnlqp mnlhglmdey lemvlqfgft tifvaafpla pllallnnii eirldaykfv
      781 tqwrrplpar atdigiwlgi legigilavi tnafviaits dyiprfvyey kygpcanhve
      841 psenclkgyv nnslsffdls elgmgksgyc ryrdyrgppw sskpyeftlq ywhilaarla
      901 fiivfehlvf giksfiayli pdvpkglhdr irrekylvqe mmyeaelehl qqqrrksgqp
      961 vhhewp
//
LOCUS       XP_054225598             835 aa            linear   PRI 05-AUG-2025
DEFINITION  anoctamin-3 isoform X2 [Homo sapiens].
ACCESSION   XP_054225598
VERSION     XP_054225598.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369623.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..835
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..835
                     /product="anoctamin-3 isoform X2"
                     /calculated_mol_wt=98154
     Region          11..235
                     /region_name="Anoct_dimer"
                     /note="dimerization domain of Ca+-activated
                     chloride-channel, anoctamin; pfam16178"
                     /db_xref="CDD:465044"
     Region          238..803
                     /region_name="Anoctamin"
                     /note="Calcium-activated chloride channel; pfam04547"
                     /db_xref="CDD:461349"
     CDS             1..835
                     /gene="ANO3"
                     /gene_synonym="C11orf25; DYT23; DYT24; GENX-3947; TMEM16C"
                     /coded_by="XM_054369623.1:212..2719"
                     /db_xref="GeneID:63982"
                     /db_xref="HGNC:HGNC:14004"
                     /db_xref="MIM:610110"
ORIGIN      
        1 mnyiassgpl fkdgkkridy ilvyrktniq ydkrntfekn lraeglmlek epaiaspdim
       61 fikihipwdt lckyaerlni rmpfrkkcyy tdgrsksmgr mqtyfrrikn wmaqnpmvld
      121 ksafpdlees dcytgpfsra rihhfiinnk dtffsnatrs rivyhmlert kyengiskvg
      181 irklinngsy iaafpphega ykssqpikth gpqnnrhlly erwarwgmwy khqpldlirl
      241 yfgekiglyf awlgwytgml ipaaivglcv ffyglftmnn sqvsqeicka tevfmcplcd
      301 kncslqrlnd sciyakvtyl fdnggtvffa ifmaiwatvf lefwkrrrsi ltytwdliew
      361 eeeeetlrpq feakyykmei vnpitgkpep hqpssdkvtr llvsvsgiff mislvitavf
      421 gvvvyrlvvm eqfasfkwnf ikqywqfats aaavcinfii imllnlayek iaylltnley
      481 prtesewens falkmflfqf vnlnssifyi afflgrfvgh pgkynklfdr wrleechpsg
      541 clidlclqmg vimflkqiwn nfmelgypli qnwwsrhkik rgihdasipq wendwnlqpm
      601 nlhglmdeyl emvlqfgftt ifvaafplap llallnniie irldaykfvt qwrrplpara
      661 tdigiwlgil egigilavit nafviaitsd yiprfvyeyk ygpcanhvep senclkgyvn
      721 nslsffdlse lgmgksgycr yrdyrgppws skpyeftlqy whilaarlaf iivfehlvfg
      781 iksfiaylip dvpkglhdri rrekylvqem myeaelehlq qqrrksgqpv hhewp
//
LOCUS       XP_054225599             738 aa            linear   PRI 05-AUG-2025
DEFINITION  anoctamin-3 isoform X3 [Homo sapiens].
ACCESSION   XP_054225599
VERSION     XP_054225599.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369624.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..738
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..738
                     /product="anoctamin-3 isoform X3"
                     /calculated_mol_wt=86614
     Region          <1..138
                     /region_name="Anoct_dimer"
                     /note="dimerization domain of Ca+-activated
                     chloride-channel, anoctamin; pfam16178"
                     /db_xref="CDD:465044"
     Region          141..706
                     /region_name="Anoctamin"
                     /note="Calcium-activated chloride channel; pfam04547"
                     /db_xref="CDD:461349"
     CDS             1..738
                     /gene="ANO3"
                     /gene_synonym="C11orf25; DYT23; DYT24; GENX-3947; TMEM16C"
                     /coded_by="XM_054369624.1:115..2331"
                     /db_xref="GeneID:63982"
                     /db_xref="HGNC:HGNC:14004"
                     /db_xref="MIM:610110"
ORIGIN      
        1 mgrmqtyfrr iknwmaqnpm vldksafpdl eesdcytgpf srarihhfii nnkdtffsna
       61 trsrivyhml ertkyengis kvgirklinn gsyiaafpph egaykssqpi kthgpqnnrh
      121 llyerwarwg mwykhqpldl irlyfgekig lyfawlgwyt gmlipaaivg lcvffyglft
      181 mnnsqvsqei ckatevfmcp lcdkncslqr lndsciyakv tylfdnggtv ffaifmaiwa
      241 tvflefwkrr rsiltytwdl ieweeeeetl rpqfeakyyk meivnpitgk pephqpssdk
      301 vtrllvsvsg iffmislvit avfgvvvyrl vvmeqfasfk wnfikqywqf atsaaavcin
      361 fiiimllnla yekiaylltn leyprtesew ensfalkmfl fqfvnlnssi fyiafflgrf
      421 vghpgkynkl fdrwrleech psgclidlcl qmgvimflkq iwnnfmelgy pliqnwwsrh
      481 kikrgihdas ipqwendwnl qpmnlhglmd eylemvlqfg fttifvaafp lapllallnn
      541 iieirldayk fvtqwrrplp aratdigiwl gilegigila vitnafviai tsdyiprfvy
      601 eykygpcanh vepsenclkg yvnnslsffd lselgmgksg ycryrdyrgp pwsskpyeft
      661 lqywhilaar lafiivfehl vfgiksfiay lipdvpkglh drirrekylv qemmyeaele
      721 hlqqqrrksg qpvhhewp
//
LOCUS       XP_054225600             515 aa            linear   PRI 05-AUG-2025
DEFINITION  anoctamin-3 isoform X4 [Homo sapiens].
ACCESSION   XP_054225600
VERSION     XP_054225600.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369625.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..515
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..515
                     /product="anoctamin-3 isoform X4"
                     /calculated_mol_wt=60527
     Region          17..483
                     /region_name="Anoctamin"
                     /note="Calcium-activated chloride channel; pfam04547"
                     /db_xref="CDD:461349"
     CDS             1..515
                     /gene="ANO3"
                     /gene_synonym="C11orf25; DYT23; DYT24; GENX-3947; TMEM16C"
                     /coded_by="XM_054369625.1:76..1623"
                     /db_xref="GeneID:63982"
                     /db_xref="HGNC:HGNC:14004"
                     /db_xref="MIM:610110"
ORIGIN      
        1 meckesaqli gprkeqatvf lefwkrrrsi ltytwdliew eeeeetlrpq feakyykmei
       61 vnpitgkpep hqpssdkvtr llvsvsgiff mislvitavf gvvvyrlvvm eqfasfkwnf
      121 ikqywqfats aaavcinfii imllnlayek iaylltnley prtesewens falkmflfqf
      181 vnlnssifyi afflgrfvgh pgkynklfdr wrleechpsg clidlclqmg vimflkqiwn
      241 nfmelgypli qnwwsrhkik rgihdasipq wendwnlqpm nlhglmdeyl emvlqfgftt
      301 ifvaafplap llallnniie irldaykfvt qwrrplpara tdigiwlgil egigilavit
      361 nafviaitsd yiprfvyeyk ygpcanhvep senclkgyvn nslsffdlse lgmgksgycr
      421 yrdyrgppws skpyeftlqy whilaarlaf iivfehlvfg iksfiaylip dvpkglhdri
      481 rrekylvqem myeaelehlq qqrrksgqpv hhewp
//
LOCUS       XP_054225601             512 aa            linear   PRI 05-AUG-2025
DEFINITION  matrix metalloproteinase-27 isoform X1 [Homo sapiens].
ACCESSION   XP_054225601
VERSION     XP_054225601.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369626.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 1% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..512
                     /product="matrix metalloproteinase-27 isoform X1"
                     /calculated_mol_wt=58837
     Region          26..86
                     /region_name="PG_binding_1"
                     /note="Putative peptidoglycan binding domain; pfam01471"
                     /db_xref="CDD:460223"
     Region          106..261
                     /region_name="Peptidase_M10"
                     /note="Matrixin; pfam00413"
                     /db_xref="CDD:425668"
     Region          275..464
                     /region_name="HX"
                     /note="Hemopexin-like repeats.; Hemopexin is a
                     heme-binding protein that transports heme to the liver.
                     Hemopexin-like repeats occur in vitronectin and some
                     matrix metalloproteinases family (matrixins). The HX
                     repeats of some matrixins bind tissue inhibitor of...;
                     cd00094"
                     /db_xref="CDD:238046"
     Site            order(285,287,329,331,376,378,425,427)
                     /site_type="metal-binding"
                     /note="Metal binding sites [ion binding]"
                     /db_xref="CDD:238046"
     CDS             1..512
                     /gene="MMP27"
                     /gene_synonym="MMP-27"
                     /coded_by="XM_054369626.1:56..1594"
                     /db_xref="GeneID:64066"
                     /db_xref="HGNC:HGNC:14250"
                     /db_xref="MIM:618101"
ORIGIN      
        1 mkrllllflf fitfssafpl vrmmeneenm qlaqaylnqf ysleiegnhl vqsknrslid
       61 dkiremqaff gltvtgklds ntleimktpr cgvpdvgqyg ytlpgwrkyn ltyriinytp
      121 dmaraavdea iqeglevwsk vtplkftkis kgiadimiaf rtrvhgrcpr yfdgplgvlg
      181 hafppgpglg gdthfdeden wtkdgagfnl flvaahefgh alglshsndq talmfpnyvs
      241 ldprkyplsq ddingiqsiy glpkvpakpk eptiphacdp dltfdaittf rrevmffkgr
      301 hlwriyydit dvefeliasf wpslpadlqa ayenprdkil vfkdenfwmi rgyavlpdyp
      361 ksihtlgfpg rvkkidaavc dkttrktyff vgiwcwrfde mtqtmdkgfp qrvvkhfpgi
      421 sirvdaafqy kgffffsrgs kqfeyniktk nitrimrtnt wfqckepkns sfgfdinkek
      481 ahsggikily hkslslfifg ivhllkntsi yq
//
LOCUS       XP_054225602             470 aa            linear   PRI 05-AUG-2025
DEFINITION  matrix metalloproteinase-27 isoform X2 [Homo sapiens].
ACCESSION   XP_054225602
VERSION     XP_054225602.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369627.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 1% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..470
                     /product="matrix metalloproteinase-27 isoform X2"
                     /calculated_mol_wt=54319
     Region          26..86
                     /region_name="PG_binding_1"
                     /note="Putative peptidoglycan binding domain; pfam01471"
                     /db_xref="CDD:460223"
     Region          106..218
                     /region_name="Peptidase_M10"
                     /note="Matrixin; pfam00413"
                     /db_xref="CDD:425668"
     Region          233..422
                     /region_name="HX"
                     /note="Hemopexin-like repeats.; Hemopexin is a
                     heme-binding protein that transports heme to the liver.
                     Hemopexin-like repeats occur in vitronectin and some
                     matrix metalloproteinases family (matrixins). The HX
                     repeats of some matrixins bind tissue inhibitor of...;
                     cd00094"
                     /db_xref="CDD:238046"
     Site            order(243,245,287,289,334,336,383,385)
                     /site_type="metal-binding"
                     /note="Metal binding sites [ion binding]"
                     /db_xref="CDD:238046"
     CDS             1..470
                     /gene="MMP27"
                     /gene_synonym="MMP-27"
                     /coded_by="XM_054369627.1:56..1468"
                     /db_xref="GeneID:64066"
                     /db_xref="HGNC:HGNC:14250"
                     /db_xref="MIM:618101"
ORIGIN      
        1 mkrllllflf fitfssafpl vrmmeneenm qlaqaylnqf ysleiegnhl vqsknrslid
       61 dkiremqaff gltvtgklds ntleimktpr cgvpdvgqyg ytlpgwrkyn ltyriinytp
      121 dmaraavdea iqeglevwsk vtplkftkis kgiadimiaf rtrgfnlflv aahefghalg
      181 lshsndqtal mfpnyvsldp rkyplsqddi ngiqsiyggl pkvpakpkep tiphacdpdl
      241 tfdaittfrr evmffkgrhl wriyyditdv efeliasfwp slpadlqaay enprdkilvf
      301 kdenfwmirg yavlpdypks ihtlgfpgrv kkidaavcdk ttrktyffvg iwcwrfdemt
      361 qtmdkgfpqr vvkhfpgisi rvdaafqykg ffffsrgskq feyniktkni trimrtntwf
      421 qckepknssf gfdinkekah sggikilyhk slslfifgiv hllkntsiyq
//
LOCUS       XP_054225603             459 aa            linear   PRI 05-AUG-2025
DEFINITION  matrix metalloproteinase-27 isoform X3 [Homo sapiens].
ACCESSION   XP_054225603
VERSION     XP_054225603.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369628.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 1% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..459
                     /product="matrix metalloproteinase-27 isoform X3"
                     /calculated_mol_wt=52888
     Region          26..86
                     /region_name="PG_binding_1"
                     /note="Putative peptidoglycan binding domain; pfam01471"
                     /db_xref="CDD:460223"
     Region          106..>204
                     /region_name="Peptidase_M10"
                     /note="Matrixin; pfam00413"
                     /db_xref="CDD:425668"
     Region          222..411
                     /region_name="HX"
                     /note="Hemopexin-like repeats.; Hemopexin is a
                     heme-binding protein that transports heme to the liver.
                     Hemopexin-like repeats occur in vitronectin and some
                     matrix metalloproteinases family (matrixins). The HX
                     repeats of some matrixins bind tissue inhibitor of...;
                     cd00094"
                     /db_xref="CDD:238046"
     Site            order(232,234,276,278,323,325,372,374)
                     /site_type="metal-binding"
                     /note="Metal binding sites [ion binding]"
                     /db_xref="CDD:238046"
     CDS             1..459
                     /gene="MMP27"
                     /gene_synonym="MMP-27"
                     /coded_by="XM_054369628.1:56..1435"
                     /db_xref="GeneID:64066"
                     /db_xref="HGNC:HGNC:14250"
                     /db_xref="MIM:618101"
ORIGIN      
        1 mkrllllflf fitfssafpl vrmmeneenm qlaqaylnqf ysleiegnhl vqsknrslid
       61 dkiremqaff gltvtgklds ntleimktpr cgvpdvgqyg ytlpgwrkyn ltyriinytp
      121 dmaraavdea iqeglevwsk vtplkftkis kgiadimiaf rtrvhgrcpr yfdgplgvlg
      181 hafppgpglg gdthfdeden wtkdgagglp kvpakpkept iphacdpdlt fdaittfrre
      241 vmffkgrhlw riyyditdve feliasfwps lpadlqaaye nprdkilvfk denfwmirgy
      301 avlpdypksi htlgfpgrvk kidaavcdkt trktyffvgi wcwrfdemtq tmdkgfpqrv
      361 vkhfpgisir vdaafqykgf fffsrgskqf eyniktknit rimrtntwfq ckepknssfg
      421 fdinkekahs ggikilyhks lslfifgivh llkntsiyq
//
LOCUS       XP_054225604             408 aa            linear   PRI 05-AUG-2025
DEFINITION  matrix metalloproteinase-27 isoform X4 [Homo sapiens].
ACCESSION   XP_054225604
VERSION     XP_054225604.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369629.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 3% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..408
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..408
                     /product="matrix metalloproteinase-27 isoform X4"
                     /calculated_mol_wt=46729
     Region          9..156
                     /region_name="Peptidase_M10"
                     /note="Matrixin; pfam00413"
                     /db_xref="CDD:425668"
     Region          171..360
                     /region_name="HX"
                     /note="Hemopexin-like repeats.; Hemopexin is a
                     heme-binding protein that transports heme to the liver.
                     Hemopexin-like repeats occur in vitronectin and some
                     matrix metalloproteinases family (matrixins). The HX
                     repeats of some matrixins bind tissue inhibitor of...;
                     cd00094"
                     /db_xref="CDD:238046"
     Site            order(181,183,225,227,272,274,321,323)
                     /site_type="metal-binding"
                     /note="Metal binding sites [ion binding]"
                     /db_xref="CDD:238046"
     CDS             1..408
                     /gene="MMP27"
                     /gene_synonym="MMP-27"
                     /coded_by="XM_054369629.1:132..1358"
                     /db_xref="GeneID:64066"
                     /db_xref="HGNC:HGNC:14250"
                     /db_xref="MIM:618101"
ORIGIN      
        1 mkkicnwlri inytpdmara avdeaiqegl evwskvtplk ftkiskgiad imiafrtrvh
       61 grcpryfdgp lgvlghafpp gpglggdthf dedenwtkdg agfnlflvaa hefghalgls
      121 hsndqtalmf pnyvsldprk yplsqdding iqsiygglpk vpakpkepti phacdpdltf
      181 daittfrrev mffkgrhlwr iyyditdvef eliasfwpsl padlqaayen prdkilvfkd
      241 enfwmirgya vlpdypksih tlgfpgrvkk idaavcdktt rktyffvgiw cwrfdemtqt
      301 mdkgfpqrvv khfpgisirv daafqykgff ffsrgskqfe yniktknitr imrtntwfqc
      361 kepknssfgf dinkekahsg gikilyhksl slfifgivhl lkntsiyq
//
LOCUS       XP_054225605             582 aa            linear   PRI 05-AUG-2025
DEFINITION  ATP-binding cassette sub-family G member 4 isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225605
VERSION     XP_054225605.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369630.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..582
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..582
                     /product="ATP-binding cassette sub-family G member 4
                     isoform X1"
                     /calculated_mol_wt=64817
     Region          15..582
                     /region_name="3a01204"
                     /note="The Eye Pigment Precursor Transporter (EPP) Family
                     protein; TIGR00955"
                     /db_xref="CDD:273361"
     CDS             1..582
                     /gene="ABCG4"
                     /gene_synonym="WHITE2"
                     /coded_by="XM_054369630.1:557..2305"
                     /db_xref="GeneID:64137"
                     /db_xref="HGNC:HGNC:13884"
                     /db_xref="MIM:607784"
ORIGIN      
        1 mcgfshafqk rivasgyktl lkclsgkfcr religimgps gagkstfmni lagyresgmk
       61 gqilvngrpr elrtfrkmsc yimqddmllp hltvleammv sanlklsekq evkkelvtei
      121 ltalglmscs htrtallsgg qrkrlaiale lvnnppvmff deptsgldsa scfqvvslmk
      181 slaqggrtii ctihqpsakl femfdklyil sqgqcifkgv vtnlipylkg lglhcptyhn
      241 padfiievas geygdlnpml fravqnglca maekksspek nevpapcppc ppevdpiesh
      301 tfatstltqf cilfkrtfls ilrdtvlthl rfmshvvigv ligllylhig ddaskvfnnt
      361 gclffsmlfl mfaalmptvl tfplemavfm rehlnywysl kayylaktma dvpfqvvcpv
      421 vycsivywmt gqpaetsrfl lfsalatata lvaqslglli gaasnslqva tfvgpvtaip
      481 vllfsgffvs fktiptylqw ssylsyvryg fegviltiyg mergdltcle ercpfrepqs
      541 ilraldveda klymdflvlg ifflalrlla ylvlryrvks er
//
LOCUS       XP_054225606             276 aa            linear   PRI 05-AUG-2025
DEFINITION  membrane-spanning 4-domains subfamily A member 6A isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225606
VERSION     XP_054225606.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369631.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..276
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..276
                     /product="membrane-spanning 4-domains subfamily A member
                     6A isoform X1"
                     /calculated_mol_wt=29919
     Region          75..236
                     /region_name="CD20"
                     /note="CD20-like family; pfam04103"
                     /db_xref="CDD:461174"
     CDS             1..276
                     /gene="MS4A6A"
                     /gene_synonym="4SPAN3; 4SPAN3.2; CD20L3; CDA01; MS4A6;
                     MST090; MSTP090"
                     /coded_by="XM_054369631.1:344..1174"
                     /db_xref="GeneID:64231"
                     /db_xref="HGNC:HGNC:13375"
                     /db_xref="MIM:606548"
ORIGIN      
        1 mvllkllevy rkgsagtfhk stifgntimt sqpvpnetii vlpsnvinfs qaekpeptnq
       61 gqdslkkhlh aeikvigtiq ilcgmmvlsl giilasasfs pnftqvtstl lnsaypfigp
      121 fffiisgsls iatekrltkl lvhsslvgsi lsalsalvgf iilsvkqatl npaslqceld
      181 knniptrsyv syfyhdslyt tdcytakasl agtlslmlic tllefclavl tavlrwkqay
      241 sdfpgsvlfl phsyignsgm sskmthdcgy eellts
//
LOCUS       XP_054225607             276 aa            linear   PRI 05-AUG-2025
DEFINITION  membrane-spanning 4-domains subfamily A member 6A isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225607
VERSION     XP_054225607.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369632.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..276
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..276
                     /product="membrane-spanning 4-domains subfamily A member
                     6A isoform X1"
                     /calculated_mol_wt=29919
     Region          75..236
                     /region_name="CD20"
                     /note="CD20-like family; pfam04103"
                     /db_xref="CDD:461174"
     CDS             1..276
                     /gene="MS4A6A"
                     /gene_synonym="4SPAN3; 4SPAN3.2; CD20L3; CDA01; MS4A6;
                     MST090; MSTP090"
                     /coded_by="XM_054369632.1:255..1085"
                     /db_xref="GeneID:64231"
                     /db_xref="HGNC:HGNC:13375"
                     /db_xref="MIM:606548"
ORIGIN      
        1 mvllkllevy rkgsagtfhk stifgntimt sqpvpnetii vlpsnvinfs qaekpeptnq
       61 gqdslkkhlh aeikvigtiq ilcgmmvlsl giilasasfs pnftqvtstl lnsaypfigp
      121 fffiisgsls iatekrltkl lvhsslvgsi lsalsalvgf iilsvkqatl npaslqceld
      181 knniptrsyv syfyhdslyt tdcytakasl agtlslmlic tllefclavl tavlrwkqay
      241 sdfpgsvlfl phsyignsgm sskmthdcgy eellts
//
LOCUS       XP_054225608             231 aa            linear   PRI 05-AUG-2025
DEFINITION  membrane-spanning 4-domains subfamily A member 6A isoform X2 [Homo
            sapiens].
ACCESSION   XP_054225608
VERSION     XP_054225608.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369633.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..231
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..231
                     /product="membrane-spanning 4-domains subfamily A member
                     6A isoform X2"
                     /calculated_mol_wt=25124
     Region          <78..191
                     /region_name="CD20"
                     /note="CD20-like family; pfam04103"
                     /db_xref="CDD:461174"
     CDS             1..231
                     /gene="MS4A6A"
                     /gene_synonym="4SPAN3; 4SPAN3.2; CD20L3; CDA01; MS4A6;
                     MST090; MSTP090"
                     /coded_by="XM_054369633.1:344..1039"
                     /db_xref="GeneID:64231"
                     /db_xref="HGNC:HGNC:13375"
                     /db_xref="MIM:606548"
ORIGIN      
        1 mvllkllevy rkgsagtfhk stifgntimt sqpvpnetii vlpsnvinfs qaekpeptnq
       61 gqdslkkhlh aeikvigfii sgslsiatek rltkllvhss lvgsilsals alvgfiilsv
      121 kqatlnpasl qceldknnip trsyvsyfyh dslyttdcyt akaslagtls lmlictllef
      181 clavltavlr wkqaysdfpg svlflphsyi gnsgmsskmt hdcgyeellt s
//
LOCUS       XP_054225609             208 aa            linear   PRI 05-AUG-2025
DEFINITION  membrane-spanning 4-domains subfamily A member 6A isoform X3 [Homo
            sapiens].
ACCESSION   XP_054225609
VERSION     XP_054225609.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369634.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..208
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..208
                     /product="membrane-spanning 4-domains subfamily A member
                     6A isoform X3"
                     /calculated_mol_wt=22512
     Region          <78..191
                     /region_name="CD20"
                     /note="CD20-like family; pfam04103"
                     /db_xref="CDD:461174"
     CDS             1..208
                     /gene="MS4A6A"
                     /gene_synonym="4SPAN3; 4SPAN3.2; CD20L3; CDA01; MS4A6;
                     MST090; MSTP090"
                     /coded_by="XM_054369634.1:344..970"
                     /db_xref="GeneID:64231"
                     /db_xref="HGNC:HGNC:13375"
                     /db_xref="MIM:606548"
ORIGIN      
        1 mvllkllevy rkgsagtfhk stifgntimt sqpvpnetii vlpsnvinfs qaekpeptnq
       61 gqdslkkhlh aeikvigfii sgslsiatek rltkllvhss lvgsilsals alvgfiilsv
      121 kqatlnpasl qceldknnip trsyvsyfyh dslyttdcyt akaslagtls lmlictllef
      181 clavltavlr wkqaysdfpg vsvlagft
//
LOCUS       XP_054225610             203 aa            linear   PRI 05-AUG-2025
DEFINITION  membrane-spanning 4-domains subfamily A member 6A isoform X4 [Homo
            sapiens].
ACCESSION   XP_054225610
VERSION     XP_054225610.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369635.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..203
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..203
                     /product="membrane-spanning 4-domains subfamily A member
                     6A isoform X4"
                     /calculated_mol_wt=22018
     Region          <50..163
                     /region_name="CD20"
                     /note="CD20-like family; pfam04103"
                     /db_xref="CDD:461174"
     CDS             1..203
                     /gene="MS4A6A"
                     /gene_synonym="4SPAN3; 4SPAN3.2; CD20L3; CDA01; MS4A6;
                     MST090; MSTP090"
                     /coded_by="XM_054369635.1:121..732"
                     /db_xref="GeneID:64231"
                     /db_xref="HGNC:HGNC:13375"
                     /db_xref="MIM:606548"
ORIGIN      
        1 mtsqpvpnet iivlpsnvin fsqaekpept nqgqdslkkh lhaeikvigf iisgslsiat
       61 ekrltkllvh sslvgsilsa lsalvgfiil svkqatlnpa slqceldknn iptrsyvsyf
      121 yhdslyttdc ytakaslagt lslmlictll efclavltav lrwkqaysdf pgsvlflphs
      181 yignsgmssk mthdcgyeel lts
//
LOCUS       XP_054225611             180 aa            linear   PRI 05-AUG-2025
DEFINITION  membrane-spanning 4-domains subfamily A member 6A isoform X5 [Homo
            sapiens].
ACCESSION   XP_054225611
VERSION     XP_054225611.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369636.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..180
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..180
                     /product="membrane-spanning 4-domains subfamily A member
                     6A isoform X5"
                     /calculated_mol_wt=19406
     Region          <50..163
                     /region_name="CD20"
                     /note="CD20-like family; pfam04103"
                     /db_xref="CDD:461174"
     CDS             1..180
                     /gene="MS4A6A"
                     /gene_synonym="4SPAN3; 4SPAN3.2; CD20L3; CDA01; MS4A6;
                     MST090; MSTP090"
                     /coded_by="XM_054369636.1:121..663"
                     /db_xref="GeneID:64231"
                     /db_xref="HGNC:HGNC:13375"
                     /db_xref="MIM:606548"
ORIGIN      
        1 mtsqpvpnet iivlpsnvin fsqaekpept nqgqdslkkh lhaeikvigf iisgslsiat
       61 ekrltkllvh sslvgsilsa lsalvgfiil svkqatlnpa slqceldknn iptrsyvsyf
      121 yhdslyttdc ytakaslagt lslmlictll efclavltav lrwkqaysdf pgvsvlagft
//
LOCUS       XP_054225612             148 aa            linear   PRI 05-AUG-2025
DEFINITION  membrane-spanning 4-domains subfamily A member 6A isoform X6 [Homo
            sapiens].
ACCESSION   XP_054225612
VERSION     XP_054225612.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369637.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..148
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..148
                     /product="membrane-spanning 4-domains subfamily A member
                     6A isoform X6"
                     /calculated_mol_wt=16010
     Region          75..>148
                     /region_name="CD20"
                     /note="CD20-like family; pfam04103"
                     /db_xref="CDD:461174"
     CDS             1..148
                     /gene="MS4A6A"
                     /gene_synonym="4SPAN3; 4SPAN3.2; CD20L3; CDA01; MS4A6;
                     MST090; MSTP090"
                     /coded_by="XM_054369637.1:344..790"
                     /db_xref="GeneID:64231"
                     /db_xref="HGNC:HGNC:13375"
                     /db_xref="MIM:606548"
ORIGIN      
        1 mvllkllevy rkgsagtfhk stifgntimt sqpvpnetii vlpsnvinfs qaekpeptnq
       61 gqdslkkhlh aeikvigtiq ilcgmmvlsl giilasasfs pnftqvtstl lnsaypfigp
      121 fffiisgsls iatekrltkl lglmleim
//
LOCUS       XP_054225613             145 aa            linear   PRI 05-AUG-2025
DEFINITION  membrane-spanning 4-domains subfamily A member 6A isoform X7 [Homo
            sapiens].
ACCESSION   XP_054225613
VERSION     XP_054225613.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369638.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..145
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..145
                     /product="membrane-spanning 4-domains subfamily A member
                     6A isoform X7"
                     /calculated_mol_wt=15626
     Region          75..>145
                     /region_name="CD20"
                     /note="CD20-like family; pfam04103"
                     /db_xref="CDD:461174"
     CDS             1..145
                     /gene="MS4A6A"
                     /gene_synonym="4SPAN3; 4SPAN3.2; CD20L3; CDA01; MS4A6;
                     MST090; MSTP090"
                     /coded_by="XM_054369638.1:344..781"
                     /db_xref="GeneID:64231"
                     /db_xref="HGNC:HGNC:13375"
                     /db_xref="MIM:606548"
ORIGIN      
        1 mvllkllevy rkgsagtfhk stifgntimt sqpvpnetii vlpsnvinfs qaekpeptnq
       61 gqdslkkhlh aeikvigtiq ilcgmmvlsl giilasasfs pnftqvtstl lnsaypfigp
      121 fffiisgsls iatekrltkl lgfls
//
LOCUS       XP_054225614             375 aa            linear   PRI 05-AUG-2025
DEFINITION  tripartite motif-containing protein 49C isoform X1 [Homo sapiens].
ACCESSION   XP_054225614
VERSION     XP_054225614.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369639.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 29% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..375
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..375
                     /product="tripartite motif-containing protein 49C isoform
                     X1"
                     /calculated_mol_wt=43435
     Region          9..67
                     /region_name="RING-HC_TRIM43-like_C-IV"
                     /note="RING finger, HC subclass, found in tripartite
                     motif-containing proteins TRIM43, TRIM48, TRIM49, TRIM51,
                     TRIM64 and similar proteins; cd16603"
                     /db_xref="CDD:438265"
     Region          87..139
                     /region_name="Bbox2_TRIM43-like"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing proteins TRIM43, TRIM48, TRIM49, TRIM51,
                     TRIM64, TRIM77 and similar proteins; cd19783"
                     /db_xref="CDD:380841"
     Region          208..371
                     /region_name="SPRY"
                     /note="SPRY domain; cl02614"
                     /db_xref="CDD:470632"
     CDS             1..375
                     /gene="TRIM49C"
                     /gene_synonym="TRIM49L2"
                     /coded_by="XM_054369639.1:5..1132"
                     /db_xref="GeneID:642612"
                     /db_xref="HGNC:HGNC:38877"
ORIGIN      
        1 mnsgilqvfq gelicplcmn yfidpvtidc ghsfcrpcfy lnwqdipflv qcsectkste
       61 qinlktnihl kkmaslarkv slwlflssee qmcgthretk kifcevdrsl lcllcsssqe
      121 hryhrhrpie waaeehrekl lqkmqslwek acenhrnlnv ettrtrcwka fgdilhrses
      181 vllhmpqpln pelsagpitg lrdrlnqfrv hitlhheean sdiflyeilr smcigcdhqd
      241 vpyftatprs flawgvqtft sgkyywevhv gdswnwafgv cnmyrkeknq nekidgkegl
      301 fllgcikndi qcslfttspl mlqyipkpts rvglfldcea ktvsfvdvnq ssliytipnc
      361 sfspplrpif ccihf
//
LOCUS       XP_054225615             446 aa            linear   PRI 05-AUG-2025
DEFINITION  tripartite motif-containing protein 49C isoform X2 [Homo sapiens].
ACCESSION   XP_054225615
VERSION     XP_054225615.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369640.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..446
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..446
                     /product="tripartite motif-containing protein 49C isoform
                     X2"
                     /calculated_mol_wt=52245
     Region          9..67
                     /region_name="RING-HC_TRIM43-like_C-IV"
                     /note="RING finger, HC subclass, found in tripartite
                     motif-containing proteins TRIM43, TRIM48, TRIM49, TRIM51,
                     TRIM64 and similar proteins; cd16603"
                     /db_xref="CDD:438265"
     Region          87..139
                     /region_name="Bbox2_TRIM43-like"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing proteins TRIM43, TRIM48, TRIM49, TRIM51,
                     TRIM64, TRIM77 and similar proteins; cd19783"
                     /db_xref="CDD:380841"
     Region          285..441
                     /region_name="SPRY"
                     /note="SPRY domain; cl02614"
                     /db_xref="CDD:470632"
     CDS             1..446
                     /gene="TRIM49C"
                     /gene_synonym="TRIM49L2"
                     /coded_by="XM_054369640.1:1..1341"
                     /db_xref="GeneID:642612"
                     /db_xref="HGNC:HGNC:38877"
ORIGIN      
        1 mnsgilqvfq gelicplcmn yfidpvtidc ghsfcrpcfy lnwqdipflv qcsectkste
       61 qinlktnihl kkmaslarkv slwlflssee qmcgthretk kifcevdrsl lcllcsssqe
      121 hryhrhrpie waaeehrekl lqkmqslwek acenhrnlnv ettrtrcwkd yvnlrleair
      181 aeyqkmpafh heeekhnlem lkkkgkeifh rlhlskakma hrmeilrgmy eelnemchkp
      241 dvellqdlgd mvarsesvll hmlqpvnpel ptgpitgpvd rlnhfrveis ftwegtnyni
      301 glfedvrslm frrgslnsdr sdyfaawgaw vfssgkhywe ldvdnswdwa lgvckdswir
      361 knstmfnskd iflllcvkvd nhfsllttsp mfphyvekpl vrvgvflnfe sgsvsflnvt
      421 knsliwnypa gslnfpvrsf fytghr
//
LOCUS       XP_054225616             372 aa            linear   PRI 05-AUG-2025
DEFINITION  C-X-C chemokine receptor type 5 isoform X1 [Homo sapiens].
ACCESSION   XP_054225616
VERSION     XP_054225616.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369641.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..372
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..372
                     /product="C-X-C chemokine receptor type 5 isoform X1"
                     /calculated_mol_wt=41824
     Region          52..333
                     /region_name="7tmA_CXCR5"
                     /note="CXC chemokine receptor type 5, member of the class
                     A family of seven-transmembrane G protein-coupled
                     receptors; cd15181"
                     /db_xref="CDD:341336"
     Region          52..79
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:341336"
     Site            order(58,107,110,126,129..130,202..207,215,218..219,275,
                     282,285,297,301,304..305,308)
                     /site_type="other"
                     /note="putative chemokine binding site [polypeptide
                     binding]"
                     /db_xref="CDD:341336"
     Region          86..111
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:341336"
     Region          122..152
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:341336"
     Region          164..186
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:341336"
     Region          215..244
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:341336"
     Region          252..282
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:341336"
     Region          301..326
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:341336"
     CDS             1..372
                     /gene="CXCR5"
                     /gene_synonym="BLR1; CD185; MDR15"
                     /coded_by="XM_054369641.1:309..1427"
                     /db_xref="GeneID:643"
                     /db_xref="HGNC:HGNC:1060"
                     /db_xref="MIM:601613"
ORIGIN      
        1 mnypltlemd lenledlfwe ldrldnyndt slvenhlcpa tegplmasfk avfvpvaysl
       61 ifllgvignv lvlvilerhr qtrsstetfl fhlavadlll vfilpfavae gsvgwvlgtf
      121 lcktvialhk vnfycsslll aciavdryla ivhavhayrh rrllsihitc gtiwlvgfll
      181 alpeilfakv sqghhnnslp rctfsqenqa ethawftsrf lyhvagfllp mlvmgwcyvg
      241 vvhrlrqaqr rpqrqkavrv ailvtsiffl cwspyhivif ldtlarlkav dntcklngsl
      301 pvaitmcefl glahcclnpm lytfagvkfr sdlsrlltkl gctgpaslcq lfpswrrssl
      361 sesenatslt tf
//
LOCUS       XP_054225617             712 aa            linear   PRI 05-AUG-2025
DEFINITION  BTB/POZ domain-containing protein 18 isoform X1 [Homo sapiens].
ACCESSION   XP_054225617
VERSION     XP_054225617.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369642.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..712
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..712
                     /product="BTB/POZ domain-containing protein 18 isoform X1"
                     /calculated_mol_wt=77801
     Region          19..138
                     /region_name="BTB_POZ_BTBD18"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in BTB/POZ
                     domain-containing protein 18 (BTBD18); cd18293"
                     /db_xref="CDD:349602"
     CDS             1..712
                     /gene="BTBD18"
                     /coded_by="XM_054369642.1:204..2342"
                     /db_xref="GeneID:643376"
                     /db_xref="HGNC:HGNC:37214"
                     /db_xref="MIM:621145"
ORIGIN      
        1 mcspaspkil yrnprflrla flqlhhqqqs dvfcdvllqa egeavpahcc ilsacspfft
       61 erlererpaq ggkvvlelgg lkistlrklv dflytsemev sqeeaqdvls aarqlrvsel
      121 eslqleggkl vkapqgrrln reclqptsaa pisarvvtps hhphtplptn qtpcplgair
      181 lkslgkeegp qennrqnadn lsgtlllkrk aracptpqek nsspsshsqe prenkndtal
      241 dptvlsppsl ypsvdkhllp rkirlsrskp spgictskps silsgsssvp atpgrrlwrq
      301 rsvnketped kpkpgraspl qstpnpsglg ktggsrkrsp evrapnsdsa eegqvgrvkl
      361 rkivngtcwe vvqetplknt qdspqipdpg gdfqepsgtq pfssneqems ptrtelcqds
      421 pmctklqdil vsashspdhp vvksefessp elvekepmla idcrepyafd talleqpcea
      481 eeyritsaaa tseleeildf mlcgsdiepp igslespgae gcrtptyhlt etgknwiege
      541 ewclpdmelw prelteleke pagenrgpte llsplvmpse vsevlsvggr wtpdleitss
      601 qpldgqedkl lhvssldtpq rsygdlsppc snwvetglev slttdellyp spkagkevsg
      661 hsellgslpa sseeeeidvv dwtaegrlvp ttvpsvwpdp ssesetevdi lt
//
LOCUS       XP_054225618             712 aa            linear   PRI 05-AUG-2025
DEFINITION  BTB/POZ domain-containing protein 18 isoform X1 [Homo sapiens].
ACCESSION   XP_054225618
VERSION     XP_054225618.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369643.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..712
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..712
                     /product="BTB/POZ domain-containing protein 18 isoform X1"
                     /calculated_mol_wt=77801
     Region          19..138
                     /region_name="BTB_POZ_BTBD18"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in BTB/POZ
                     domain-containing protein 18 (BTBD18); cd18293"
                     /db_xref="CDD:349602"
     CDS             1..712
                     /gene="BTBD18"
                     /coded_by="XM_054369643.1:1087..3225"
                     /db_xref="GeneID:643376"
                     /db_xref="HGNC:HGNC:37214"
                     /db_xref="MIM:621145"
ORIGIN      
        1 mcspaspkil yrnprflrla flqlhhqqqs dvfcdvllqa egeavpahcc ilsacspfft
       61 erlererpaq ggkvvlelgg lkistlrklv dflytsemev sqeeaqdvls aarqlrvsel
      121 eslqleggkl vkapqgrrln reclqptsaa pisarvvtps hhphtplptn qtpcplgair
      181 lkslgkeegp qennrqnadn lsgtlllkrk aracptpqek nsspsshsqe prenkndtal
      241 dptvlsppsl ypsvdkhllp rkirlsrskp spgictskps silsgsssvp atpgrrlwrq
      301 rsvnketped kpkpgraspl qstpnpsglg ktggsrkrsp evrapnsdsa eegqvgrvkl
      361 rkivngtcwe vvqetplknt qdspqipdpg gdfqepsgtq pfssneqems ptrtelcqds
      421 pmctklqdil vsashspdhp vvksefessp elvekepmla idcrepyafd talleqpcea
      481 eeyritsaaa tseleeildf mlcgsdiepp igslespgae gcrtptyhlt etgknwiege
      541 ewclpdmelw prelteleke pagenrgpte llsplvmpse vsevlsvggr wtpdleitss
      601 qpldgqedkl lhvssldtpq rsygdlsppc snwvetglev slttdellyp spkagkevsg
      661 hsellgslpa sseeeeidvv dwtaegrlvp ttvpsvwpdp ssesetevdi lt
//
LOCUS       XP_054225619             229 aa            linear   PRI 05-AUG-2025
DEFINITION  putative membrane-spanning 4-domains subfamily A member 4E isoform
            X1 [Homo sapiens].
ACCESSION   XP_054225619
VERSION     XP_054225619.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369644.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 1% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..229
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..229
                     /product="putative membrane-spanning 4-domains subfamily A
                     member 4E isoform X1"
                     /calculated_mol_wt=25179
     Region          <61..152
                     /region_name="CD20"
                     /note="CD20-like family; pfam04103"
                     /db_xref="CDD:461174"
     CDS             1..229
                     /gene="MS4A4E"
                     /coded_by="XM_054369644.1:197..886"
                     /db_xref="GeneID:643680"
                     /db_xref="HGNC:HGNC:14284"
                     /db_xref="MIM:608401"
ORIGIN      
        1 mttmqgmeqt tpgagpdvpq lgnidvihsy lckglqekff krkpkvlgvl cghkfsthsv
       61 slsvaagirt tkglvggslg knitssvlai sgilinaisl tfysfryhyc nhdqlssncy
      121 mtmsilmgtd gmvlllsvle fciavslsaf gckvlccsps esknkirsnt fmcyllsiqm
      181 qydgkrlnvd vdstvwcsgd gqylekvyyd ilsswlrier sqsyhrtsl
//
LOCUS       XP_054225620             180 aa            linear   PRI 05-AUG-2025
DEFINITION  putative membrane-spanning 4-domains subfamily A member 4E isoform
            X2 [Homo sapiens].
ACCESSION   XP_054225620
VERSION     XP_054225620.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369645.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 1% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..180
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..180
                     /product="putative membrane-spanning 4-domains subfamily A
                     member 4E isoform X2"
                     /calculated_mol_wt=19316
     Region          <61..152
                     /region_name="CD20"
                     /note="CD20-like family; pfam04103"
                     /db_xref="CDD:461174"
     CDS             1..180
                     /gene="MS4A4E"
                     /coded_by="XM_054369645.1:197..739"
                     /db_xref="GeneID:643680"
                     /db_xref="HGNC:HGNC:14284"
                     /db_xref="MIM:608401"
ORIGIN      
        1 mttmqgmeqt tpgagpdvpq lgnidvihsy lckglqekff krkpkvlgvl cghkfsthsv
       61 slsvaagirt tkglvggslg knitssvlai sgilinaisl tfysfryhyc nhdqlssncy
      121 mtmsilmgtd gmvlllsvle fciavslsaf gckvlccsps efpwikslgp vdvgpwfril
//
LOCUS       XP_054225621             166 aa            linear   PRI 05-AUG-2025
DEFINITION  cilia- and flagella-associated protein 68 isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225621
VERSION     XP_054225621.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369646.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..166
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..166
                     /product="cilia- and flagella-associated protein 68
                     isoform X1"
                     /calculated_mol_wt=19336
     Region          32..165
                     /region_name="DUF1143"
                     /note="Protein of unknown function (DUF1143); pfam06608"
                     /db_xref="CDD:461959"
     CDS             1..166
                     /gene="CFAP68"
                     /gene_synonym="C11orf1"
                     /coded_by="XM_054369646.1:104..604"
                     /db_xref="GeneID:64776"
                     /db_xref="HGNC:HGNC:1163"
ORIGIN      
        1 meqpskdfcd shkkssksst ysassysssg krqnlacflt nphcgslvna dghgevwtdw
       61 nnmskffqyg wrcttnenty snrtlmgnwn qerydlrniv qpkplpsqfg hyfettydts
      121 ynnkmplsth rfkrephwfp ghqpeldppr ykctekstym nsyskp
//
LOCUS       XP_054225623             622 aa            linear   PRI 05-AUG-2025
DEFINITION  kinesin light chain 2 isoform X1 [Homo sapiens].
ACCESSION   XP_054225623
VERSION     XP_054225623.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369648.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..622
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..622
                     /product="kinesin light chain 2 isoform X1"
                     /calculated_mol_wt=68751
     Region          26..>132
                     /region_name="Crescentin"
                     /note="Crescentin protein; pfam19220"
                     /db_xref="CDD:437057"
     Region          195..434
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          199..226
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          240..268
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          282..310
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(283,286..287,290..291,293,325,328..329,332..333,
                     335..336,367,370..371,374..375,378)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          323..353
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          366..393
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..622
                     /gene="KLC2"
                     /coded_by="XM_054369648.1:77..1945"
                     /db_xref="GeneID:64837"
                     /db_xref="HGNC:HGNC:20716"
                     /db_xref="MIM:611729"
ORIGIN      
        1 mammvfpree klsqdeivlg tkaviqglet lrgehralla plvapeagea epgsqercil
       61 lrrsleaiel glgeaqvila lsshlgaves ekqklraqvr rlvqenqwlr eelagtqqkl
      121 qrseqavaql eeekqhllfm sqirkldeda spneekgdvp kdtlddlfpn edeqspapsp
      181 gggdvsgqhg gyeiparlrt lhnlviqyas qgryevavpl ckqaledlek tsghdhpdva
      241 tmlnilalvy rdqnkykeaa hllndalair ektlgkdhpa vaatlnnlav lygkrgkyke
      301 aeplckrale irekvlgkfh pdvakqlsnl allcqnqgka eeveyyyrra leiyatrlgp
      361 ddpnvaktkn nlascylkqg kyqdaetlyk eiltraheke fgsvngdnkp iwmhaeeree
      421 skdkrrdsap ygeygswyka ckvdsptvnt tlrslgalyr rqgkleaaht ledcasrnrk
      481 qgldpasqtk vvellkdgsg rrgdcrssrd maggagprse sdledvgpta ewngdgsgsl
      541 rrsgsfgklr dalrrsseml vkklqggtpq eppnprmkra sslnflnksv eeptqpggtg
      601 lsdsrtlsss smdlsrrssl vg
//
LOCUS       XP_054225624             600 aa            linear   PRI 05-AUG-2025
DEFINITION  kinesin light chain 2 isoform X2 [Homo sapiens].
ACCESSION   XP_054225624
VERSION     XP_054225624.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369649.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..600
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..600
                     /product="kinesin light chain 2 isoform X2"
                     /calculated_mol_wt=66550
     Region          26..>132
                     /region_name="Crescentin"
                     /note="Crescentin protein; pfam19220"
                     /db_xref="CDD:437057"
     Region          195..434
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          199..226
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          240..268
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          282..310
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(283,286..287,290..291,293,325,328..329,332..333,
                     335..336,367,370..371,374..375,378)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          323..353
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          366..393
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..600
                     /gene="KLC2"
                     /coded_by="XM_054369649.1:181..1983"
                     /db_xref="GeneID:64837"
                     /db_xref="HGNC:HGNC:20716"
                     /db_xref="MIM:611729"
ORIGIN      
        1 mammvfpree klsqdeivlg tkaviqglet lrgehralla plvapeagea epgsqercil
       61 lrrsleaiel glgeaqvila lsshlgaves ekqklraqvr rlvqenqwlr eelagtqqkl
      121 qrseqavaql eeekqhllfm sqirkldeda spneekgdvp kdtlddlfpn edeqspapsp
      181 gggdvsgqhg gyeiparlrt lhnlviqyas qgryevavpl ckqaledlek tsghdhpdva
      241 tmlnilalvy rdqnkykeaa hllndalair ektlgkdhpa vaatlnnlav lygkrgkyke
      301 aeplckrale irekvlgkfh pdvakqlsnl allcqnqgka eeveyyyrra leiyatrlgp
      361 ddpnvaktkn nlascylkqg kyqdaetlyk eiltraheke fgsvngdnkp iwmhaeeree
      421 skdkrrdsap ygeygswyka ckvdsptvnt tlrslgalyr rqgkleaaht ledcasrnrk
      481 qgldpasqtk vvellkdgsg rrgdcrssrd maggagprse sdledvgpta ewngdgsgsl
      541 rrsgsfgklr dalrrsseml vkklqggtpq eppnprmkra sslnflnksv eeptqqgplp
//
LOCUS       XP_054225625             600 aa            linear   PRI 05-AUG-2025
DEFINITION  kinesin light chain 2 isoform X2 [Homo sapiens].
ACCESSION   XP_054225625
VERSION     XP_054225625.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369650.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..600
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..600
                     /product="kinesin light chain 2 isoform X2"
                     /calculated_mol_wt=66550
     Region          26..>132
                     /region_name="Crescentin"
                     /note="Crescentin protein; pfam19220"
                     /db_xref="CDD:437057"
     Region          195..434
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          199..226
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          240..268
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          282..310
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(283,286..287,290..291,293,325,328..329,332..333,
                     335..336,367,370..371,374..375,378)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          323..353
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          366..393
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..600
                     /gene="KLC2"
                     /coded_by="XM_054369650.1:218..2020"
                     /db_xref="GeneID:64837"
                     /db_xref="HGNC:HGNC:20716"
                     /db_xref="MIM:611729"
ORIGIN      
        1 mammvfpree klsqdeivlg tkaviqglet lrgehralla plvapeagea epgsqercil
       61 lrrsleaiel glgeaqvila lsshlgaves ekqklraqvr rlvqenqwlr eelagtqqkl
      121 qrseqavaql eeekqhllfm sqirkldeda spneekgdvp kdtlddlfpn edeqspapsp
      181 gggdvsgqhg gyeiparlrt lhnlviqyas qgryevavpl ckqaledlek tsghdhpdva
      241 tmlnilalvy rdqnkykeaa hllndalair ektlgkdhpa vaatlnnlav lygkrgkyke
      301 aeplckrale irekvlgkfh pdvakqlsnl allcqnqgka eeveyyyrra leiyatrlgp
      361 ddpnvaktkn nlascylkqg kyqdaetlyk eiltraheke fgsvngdnkp iwmhaeeree
      421 skdkrrdsap ygeygswyka ckvdsptvnt tlrslgalyr rqgkleaaht ledcasrnrk
      481 qgldpasqtk vvellkdgsg rrgdcrssrd maggagprse sdledvgpta ewngdgsgsl
      541 rrsgsfgklr dalrrsseml vkklqggtpq eppnprmkra sslnflnksv eeptqqgplp
//
LOCUS       XP_054225626             600 aa            linear   PRI 05-AUG-2025
DEFINITION  kinesin light chain 2 isoform X2 [Homo sapiens].
ACCESSION   XP_054225626
VERSION     XP_054225626.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369651.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..600
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..600
                     /product="kinesin light chain 2 isoform X2"
                     /calculated_mol_wt=66550
     Region          26..>132
                     /region_name="Crescentin"
                     /note="Crescentin protein; pfam19220"
                     /db_xref="CDD:437057"
     Region          195..434
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          199..226
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          240..268
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          282..310
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(283,286..287,290..291,293,325,328..329,332..333,
                     335..336,367,370..371,374..375,378)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          323..353
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          366..393
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..600
                     /gene="KLC2"
                     /coded_by="XM_054369651.1:77..1879"
                     /db_xref="GeneID:64837"
                     /db_xref="HGNC:HGNC:20716"
                     /db_xref="MIM:611729"
ORIGIN      
        1 mammvfpree klsqdeivlg tkaviqglet lrgehralla plvapeagea epgsqercil
       61 lrrsleaiel glgeaqvila lsshlgaves ekqklraqvr rlvqenqwlr eelagtqqkl
      121 qrseqavaql eeekqhllfm sqirkldeda spneekgdvp kdtlddlfpn edeqspapsp
      181 gggdvsgqhg gyeiparlrt lhnlviqyas qgryevavpl ckqaledlek tsghdhpdva
      241 tmlnilalvy rdqnkykeaa hllndalair ektlgkdhpa vaatlnnlav lygkrgkyke
      301 aeplckrale irekvlgkfh pdvakqlsnl allcqnqgka eeveyyyrra leiyatrlgp
      361 ddpnvaktkn nlascylkqg kyqdaetlyk eiltraheke fgsvngdnkp iwmhaeeree
      421 skdkrrdsap ygeygswyka ckvdsptvnt tlrslgalyr rqgkleaaht ledcasrnrk
      481 qgldpasqtk vvellkdgsg rrgdcrssrd maggagprse sdledvgpta ewngdgsgsl
      541 rrsgsfgklr dalrrsseml vkklqggtpq eppnprmkra sslnflnksv eeptqqgplp
//
LOCUS       XP_054225627             600 aa            linear   PRI 05-AUG-2025
DEFINITION  kinesin light chain 2 isoform X2 [Homo sapiens].
ACCESSION   XP_054225627
VERSION     XP_054225627.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369652.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..600
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..600
                     /product="kinesin light chain 2 isoform X2"
                     /calculated_mol_wt=66550
     Region          26..>132
                     /region_name="Crescentin"
                     /note="Crescentin protein; pfam19220"
                     /db_xref="CDD:437057"
     Region          195..434
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          199..226
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          240..268
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          282..310
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(283,286..287,290..291,293,325,328..329,332..333,
                     335..336,367,370..371,374..375,378)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          323..353
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          366..393
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..600
                     /gene="KLC2"
                     /coded_by="XM_054369652.1:40..1842"
                     /db_xref="GeneID:64837"
                     /db_xref="HGNC:HGNC:20716"
                     /db_xref="MIM:611729"
ORIGIN      
        1 mammvfpree klsqdeivlg tkaviqglet lrgehralla plvapeagea epgsqercil
       61 lrrsleaiel glgeaqvila lsshlgaves ekqklraqvr rlvqenqwlr eelagtqqkl
      121 qrseqavaql eeekqhllfm sqirkldeda spneekgdvp kdtlddlfpn edeqspapsp
      181 gggdvsgqhg gyeiparlrt lhnlviqyas qgryevavpl ckqaledlek tsghdhpdva
      241 tmlnilalvy rdqnkykeaa hllndalair ektlgkdhpa vaatlnnlav lygkrgkyke
      301 aeplckrale irekvlgkfh pdvakqlsnl allcqnqgka eeveyyyrra leiyatrlgp
      361 ddpnvaktkn nlascylkqg kyqdaetlyk eiltraheke fgsvngdnkp iwmhaeeree
      421 skdkrrdsap ygeygswyka ckvdsptvnt tlrslgalyr rqgkleaaht ledcasrnrk
      481 qgldpasqtk vvellkdgsg rrgdcrssrd maggagprse sdledvgpta ewngdgsgsl
      541 rrsgsfgklr dalrrsseml vkklqggtpq eppnprmkra sslnflnksv eeptqqgplp
//
LOCUS       XP_054225628             333 aa            linear   PRI 05-AUG-2025
DEFINITION  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,
            3-sialyltransferase 4 isoform X1 [Homo sapiens].
ACCESSION   XP_054225628
VERSION     XP_054225628.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369653.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..333
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..333
                     /product="CMP-N-acetylneuraminate-beta-galactosamide-
                     alpha-2,3-sialyltransferase 4 isoform X1"
                     /calculated_mol_wt=37914
     Region          116..321
                     /region_name="GT29_ST3GAL4"
                     /note="beta-galactoside alpha-2,3-sialyltransferase 4;
                     cd23982"
                     /db_xref="CDD:467710"
     Site            order(124..126,147..148,169,260..262,280..281,292..294,
                     309)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:467710"
     CDS             1..333
                     /gene="ST3GAL4"
                     /gene_synonym="CGS23; gal-NAc6S; NANTA3; SAT3; SIAT4;
                     SIAT4C; ST-4; ST3GalA.2; ST3GalIV; STZ"
                     /coded_by="XM_054369653.1:152..1153"
                     /db_xref="GeneID:6484"
                     /db_xref="HGNC:HGNC:10864"
                     /db_xref="MIM:104240"
ORIGIN      
        1 mvsksrwkll amlalvlvvm vwysisredr yielfyfpip ekkepclqge aeskasklfg
       61 nysrdqpifl rledyfwvkt psayelpygt kgsedlllrv laitsssipk niqslrcrrc
      121 vvvgnghrlr nsslgdaink ydvvirlnna pvagyegdvg skttmrlfyp esahfdpkve
      181 nnpdtllvlv afkamdfhwi etilsdkkrv rkgfwkqppl iwdvnpkqir ilnpffmeia
      241 adkllslpmq qprkikqkpt tgllaitlal hlcdlvhiag fgypdaynkk qtihyyeqit
      301 lksmagsghn vsqealaikr mlemgaiknl tsf
//
LOCUS       XP_054225629             333 aa            linear   PRI 05-AUG-2025
DEFINITION  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,
            3-sialyltransferase 4 isoform X1 [Homo sapiens].
ACCESSION   XP_054225629
VERSION     XP_054225629.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369654.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..333
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..333
                     /product="CMP-N-acetylneuraminate-beta-galactosamide-
                     alpha-2,3-sialyltransferase 4 isoform X1"
                     /calculated_mol_wt=37914
     Region          116..321
                     /region_name="GT29_ST3GAL4"
                     /note="beta-galactoside alpha-2,3-sialyltransferase 4;
                     cd23982"
                     /db_xref="CDD:467710"
     Site            order(124..126,147..148,169,260..262,280..281,292..294,
                     309)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:467710"
     CDS             1..333
                     /gene="ST3GAL4"
                     /gene_synonym="CGS23; gal-NAc6S; NANTA3; SAT3; SIAT4;
                     SIAT4C; ST-4; ST3GalA.2; ST3GalIV; STZ"
                     /coded_by="XM_054369654.1:116..1117"
                     /db_xref="GeneID:6484"
                     /db_xref="HGNC:HGNC:10864"
                     /db_xref="MIM:104240"
ORIGIN      
        1 mvsksrwkll amlalvlvvm vwysisredr yielfyfpip ekkepclqge aeskasklfg
       61 nysrdqpifl rledyfwvkt psayelpygt kgsedlllrv laitsssipk niqslrcrrc
      121 vvvgnghrlr nsslgdaink ydvvirlnna pvagyegdvg skttmrlfyp esahfdpkve
      181 nnpdtllvlv afkamdfhwi etilsdkkrv rkgfwkqppl iwdvnpkqir ilnpffmeia
      241 adkllslpmq qprkikqkpt tgllaitlal hlcdlvhiag fgypdaynkk qtihyyeqit
      301 lksmagsghn vsqealaikr mlemgaiknl tsf
//
LOCUS       XP_054225630             329 aa            linear   PRI 05-AUG-2025
DEFINITION  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,
            3-sialyltransferase 4 isoform X2 [Homo sapiens].
ACCESSION   XP_054225630
VERSION     XP_054225630.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369655.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..329
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..329
                     /product="CMP-N-acetylneuraminate-beta-galactosamide-
                     alpha-2,3-sialyltransferase 4 isoform X2"
                     /calculated_mol_wt=37327
     Region          112..317
                     /region_name="GT29_ST3GAL4"
                     /note="beta-galactoside alpha-2,3-sialyltransferase 4;
                     cd23982"
                     /db_xref="CDD:467710"
     Site            order(120..122,143..144,165,256..258,276..277,288..290,
                     305)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:467710"
     CDS             1..329
                     /gene="ST3GAL4"
                     /gene_synonym="CGS23; gal-NAc6S; NANTA3; SAT3; SIAT4;
                     SIAT4C; ST-4; ST3GalA.2; ST3GalIV; STZ"
                     /coded_by="XM_054369655.1:80..1069"
                     /db_xref="GeneID:6484"
                     /db_xref="HGNC:HGNC:10864"
                     /db_xref="MIM:104240"
ORIGIN      
        1 mvsksrwkll amlalvlvvm vwysisreds fyfpipekke pclqgeaesk asklfgnysr
       61 dqpiflrled yfwvktpsay elpygtkgse dlllrvlait sssipkniqs lrcrrcvvvg
      121 nghrlrnssl gdainkydvv irlnnapvag yegdvgsktt mrlfypesah fdpkvennpd
      181 tllvlvafka mdfhwietil sdkkrvrkgf wkqppliwdv npkqirilnp ffmeiaadkl
      241 lslpmqqprk ikqkpttgll aitlalhlcd lvhiagfgyp daynkkqtih yyeqitlksm
      301 agsghnvsqe alaikrmlem gaiknltsf
//
LOCUS       XP_054225631             370 aa            linear   PRI 05-AUG-2025
DEFINITION  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,
            3-sialyltransferase 4 isoform X3 [Homo sapiens].
ACCESSION   XP_054225631
VERSION     XP_054225631.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369656.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..370
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..370
                     /product="CMP-N-acetylneuraminate-beta-galactosamide-
                     alpha-2,3-sialyltransferase 4 isoform X3"
                     /calculated_mol_wt=41746
     Region          153..358
                     /region_name="GT29_ST3GAL4"
                     /note="beta-galactoside alpha-2,3-sialyltransferase 4;
                     cd23982"
                     /db_xref="CDD:467710"
     Site            order(161..163,184..185,206,297..299,317..318,329..331,
                     346)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:467710"
     CDS             1..370
                     /gene="ST3GAL4"
                     /gene_synonym="CGS23; gal-NAc6S; NANTA3; SAT3; SIAT4;
                     SIAT4C; ST-4; ST3GalA.2; ST3GalIV; STZ"
                     /coded_by="XM_054369656.1:13..1125"
                     /db_xref="GeneID:6484"
                     /db_xref="HGNC:HGNC:10864"
                     /db_xref="MIM:104240"
ORIGIN      
        1 meeesalagg apqaleavar gsrddsspqe sccllrnmvs ksrwkllaml alvlvvmvwy
       61 sisredryie lfyfpipekk epclqgeaes kasklfgnys rdqpiflrle dyfwvktpsa
      121 yelpygtkgs edlllrvlai tsssipkniq slrcrrcvvv gnghrlrnss lgdainkydv
      181 virlnnapva gyegdvgskt tmrlfypesa hfdpkvennp dtllvlvafk amdfhwieti
      241 lsdkkrvrkg fwkqppliwd vnpkqiriln pffmeiaadk llslpmqqpr kikqkpttgl
      301 laitlalhlc dlvhiagfgy pdaynkkqti hyyeqitlks magsghnvsq ealaikrmle
      361 mgaiknltsf
//
LOCUS       XP_054225632             356 aa            linear   PRI 05-AUG-2025
DEFINITION  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,
            3-sialyltransferase 4 isoform X4 [Homo sapiens].
ACCESSION   XP_054225632
VERSION     XP_054225632.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369657.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..356
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..356
                     /product="CMP-N-acetylneuraminate-beta-galactosamide-
                     alpha-2,3-sialyltransferase 4 isoform X4"
                     /calculated_mol_wt=40463
     Region          139..344
                     /region_name="GT29_ST3GAL4"
                     /note="beta-galactoside alpha-2,3-sialyltransferase 4;
                     cd23982"
                     /db_xref="CDD:467710"
     Site            order(147..149,170..171,192,283..285,303..304,315..317,
                     332)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:467710"
     CDS             1..356
                     /gene="ST3GAL4"
                     /gene_synonym="CGS23; gal-NAc6S; NANTA3; SAT3; SIAT4;
                     SIAT4C; ST-4; ST3GalA.2; ST3GalIV; STZ"
                     /coded_by="XM_054369657.1:265..1335"
                     /db_xref="GeneID:6484"
                     /db_xref="HGNC:HGNC:10864"
                     /db_xref="MIM:104240"
ORIGIN      
        1 melvargsrd dsspqesccl lrnmvsksrw kllamlalvl vvmvwysisr edryielfyf
       61 pipekkepcl qgeaeskask lfgnysrdqp iflrledyfw vktpsayelp ygtkgsedll
      121 lrvlaitsss ipkniqslrc rrcvvvgngh rlrnsslgda inkydvvirl nnapvagyeg
      181 dvgskttmrl fypesahfdp kvennpdtll vlvafkamdf hwietilsdk krvrkgfwkq
      241 ppliwdvnpk qirilnpffm eiaadkllsl pmqqprkikq kpttgllait lalhlcdlvh
      301 iagfgypday nkkqtihyye qitlksmags ghnvsqeala ikrmlemgai knltsf
//
LOCUS       XP_054225633             354 aa            linear   PRI 05-AUG-2025
DEFINITION  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,
            3-sialyltransferase 4 isoform X5 [Homo sapiens].
ACCESSION   XP_054225633
VERSION     XP_054225633.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369658.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..354
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..354
                     /product="CMP-N-acetylneuraminate-beta-galactosamide-
                     alpha-2,3-sialyltransferase 4 isoform X5"
                     /calculated_mol_wt=40221
     Region          137..342
                     /region_name="GT29_ST3GAL4"
                     /note="beta-galactoside alpha-2,3-sialyltransferase 4;
                     cd23982"
                     /db_xref="CDD:467710"
     Site            order(145..147,168..169,190,281..283,301..302,313..315,
                     330)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:467710"
     CDS             1..354
                     /gene="ST3GAL4"
                     /gene_synonym="CGS23; gal-NAc6S; NANTA3; SAT3; SIAT4;
                     SIAT4C; ST-4; ST3GalA.2; ST3GalIV; STZ"
                     /coded_by="XM_054369658.1:118..1182"
                     /db_xref="GeneID:6484"
                     /db_xref="HGNC:HGNC:10864"
                     /db_xref="MIM:104240"
ORIGIN      
        1 mvargsrdds spqesccllr nmvsksrwkl lamlalvlvv mvwysisred ryielfyfpi
       61 pekkepclqg eaeskasklf gnysrdqpif lrledyfwvk tpsayelpyg tkgsedlllr
      121 vlaitsssip kniqslrcrr cvvvgnghrl rnsslgdain kydvvirlnn apvagyegdv
      181 gskttmrlfy pesahfdpkv ennpdtllvl vafkamdfhw ietilsdkkr vrkgfwkqpp
      241 liwdvnpkqi rilnpffmei aadkllslpm qqprkikqkp ttgllaitla lhlcdlvhia
      301 gfgypdaynk kqtihyyeqi tlksmagsgh nvsqealaik rmlemgaikn ltsf
//
LOCUS       XP_054225634             352 aa            linear   PRI 05-AUG-2025
DEFINITION  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,
            3-sialyltransferase 4 isoform X6 [Homo sapiens].
ACCESSION   XP_054225634
VERSION     XP_054225634.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369659.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..352
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..352
                     /product="CMP-N-acetylneuraminate-beta-galactosamide-
                     alpha-2,3-sialyltransferase 4 isoform X6"
                     /calculated_mol_wt=39876
     Region          135..340
                     /region_name="GT29_ST3GAL4"
                     /note="beta-galactoside alpha-2,3-sialyltransferase 4;
                     cd23982"
                     /db_xref="CDD:467710"
     Site            order(143..145,166..167,188,279..281,299..300,311..313,
                     328)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:467710"
     CDS             1..352
                     /gene="ST3GAL4"
                     /gene_synonym="CGS23; gal-NAc6S; NANTA3; SAT3; SIAT4;
                     SIAT4C; ST-4; ST3GalA.2; ST3GalIV; STZ"
                     /coded_by="XM_054369659.1:279..1337"
                     /db_xref="GeneID:6484"
                     /db_xref="HGNC:HGNC:10864"
                     /db_xref="MIM:104240"
ORIGIN      
        1 melvargsrd dsspqesccl lrnmvsksrw kllamlalvl vvmvwysisr edsfyfpipe
       61 kkepclqgea eskasklfgn ysrdqpiflr ledyfwvktp sayelpygtk gsedlllrvl
      121 aitsssipkn iqslrcrrcv vvgnghrlrn sslgdainky dvvirlnnap vagyegdvgs
      181 kttmrlfype sahfdpkven npdtllvlva fkamdfhwie tilsdkkrvr kgfwkqppli
      241 wdvnpkqiri lnpffmeiaa dkllslpmqq prkikqkptt gllaitlalh lcdlvhiagf
      301 gypdaynkkq tihyyeqitl ksmagsghnv sqealaikrm lemgaiknlt sf
//
LOCUS       XP_054225635             350 aa            linear   PRI 05-AUG-2025
DEFINITION  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,
            3-sialyltransferase 4 isoform X7 [Homo sapiens].
ACCESSION   XP_054225635
VERSION     XP_054225635.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369660.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..350
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..350
                     /product="CMP-N-acetylneuraminate-beta-galactosamide-
                     alpha-2,3-sialyltransferase 4 isoform X7"
                     /calculated_mol_wt=39633
     Region          133..338
                     /region_name="GT29_ST3GAL4"
                     /note="beta-galactoside alpha-2,3-sialyltransferase 4;
                     cd23982"
                     /db_xref="CDD:467710"
     Site            order(141..143,164..165,186,277..279,297..298,309..311,
                     326)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:467710"
     CDS             1..350
                     /gene="ST3GAL4"
                     /gene_synonym="CGS23; gal-NAc6S; NANTA3; SAT3; SIAT4;
                     SIAT4C; ST-4; ST3GalA.2; ST3GalIV; STZ"
                     /coded_by="XM_054369660.1:132..1184"
                     /db_xref="GeneID:6484"
                     /db_xref="HGNC:HGNC:10864"
                     /db_xref="MIM:104240"
ORIGIN      
        1 mvargsrdds spqesccllr nmvsksrwkl lamlalvlvv mvwysisred sfyfpipekk
       61 epclqgeaes kasklfgnys rdqpiflrle dyfwvktpsa yelpygtkgs edlllrvlai
      121 tsssipkniq slrcrrcvvv gnghrlrnss lgdainkydv virlnnapva gyegdvgskt
      181 tmrlfypesa hfdpkvennp dtllvlvafk amdfhwieti lsdkkrvrkg fwkqppliwd
      241 vnpkqiriln pffmeiaadk llslpmqqpr kikqkpttgl laitlalhlc dlvhiagfgy
      301 pdaynkkqti hyyeqitlks magsghnvsq ealaikrmle mgaiknltsf
//
LOCUS       XP_054225636             350 aa            linear   PRI 05-AUG-2025
DEFINITION  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,
            3-sialyltransferase 4 isoform X8 [Homo sapiens].
ACCESSION   XP_054225636
VERSION     XP_054225636.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369661.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..350
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..350
                     /product="CMP-N-acetylneuraminate-beta-galactosamide-
                     alpha-2,3-sialyltransferase 4 isoform X8"
                     /calculated_mol_wt=39633
     Region          133..338
                     /region_name="GT29_ST3GAL4"
                     /note="beta-galactoside alpha-2,3-sialyltransferase 4;
                     cd23982"
                     /db_xref="CDD:467710"
     Site            order(141..143,164..165,186,277..279,297..298,309..311,
                     326)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:467710"
     CDS             1..350
                     /gene="ST3GAL4"
                     /gene_synonym="CGS23; gal-NAc6S; NANTA3; SAT3; SIAT4;
                     SIAT4C; ST-4; ST3GalA.2; ST3GalIV; STZ"
                     /coded_by="XM_054369661.1:440..1492"
                     /db_xref="GeneID:6484"
                     /db_xref="HGNC:HGNC:10864"
                     /db_xref="MIM:104240"
ORIGIN      
        1 mvargsrdds spqesccllr nmvsksrwkl lamlalvlvv mvwysisred sfyfpipekk
       61 epclqgeaes kasklfgnys rdqpiflrle dyfwvktpsa yelpygtkgs edlllrvlai
      121 tsssipkniq slrcrrcvvv gnghrlrnss lgdainkydv virlnnapva gyegdvgskt
      181 tmrlfypesa hfdpkvennp dtllvlvafk amdfhwieti lsdkkrvrkg fwkqppliwd
      241 vnpkqiriln pffmeiaadk llslpmqqpr kikqkpttgl laitlalhlc dlvhiagfgy
      301 pdaynkkqti hyyeqitlks magsghnvsq ealaikrmle mgaiknltsf
//
LOCUS       XP_054225637            1042 aa            linear   PRI 05-AUG-2025
DEFINITION  signal-induced proliferation-associated protein 1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225637
VERSION     XP_054225637.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369662.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 1% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1042
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1042
                     /product="signal-induced proliferation-associated protein
                     1 isoform X1"
                     /calculated_mol_wt=112018
     Region          351..532
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     Region          687..759
                     /region_name="PDZ_SIPA1-like"
                     /note="PDZ domain of signal-induced
                     proliferation-associated protein 1 (SIPA1), and related
                     domains; cd06745"
                     /db_xref="CDD:467227"
     Site            order(697..703,709,712,741,745,748..749)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467227"
     Region          974..1030
                     /region_name="ZapB"
                     /note="Cell division protein ZapB; pfam06005"
                     /db_xref="CDD:428718"
     CDS             1..1042
                     /gene="SIPA1"
                     /gene_synonym="SPA1"
                     /coded_by="XM_054369662.1:2470..5598"
                     /db_xref="GeneID:6494"
                     /db_xref="HGNC:HGNC:10885"
                     /db_xref="MIM:602180"
ORIGIN      
        1 mpmwaggvgs prrgmapast ddlfarklrq parppltpht feprpvrgpl lrsgsdagea
       61 rpptpaspra rahsheeasr paatstrlft dplallglpa eepepafppv leprwfahyd
      121 vqsllfdwap rsqgmgshse assgtlasae dqaassdllh gapgfvcelg gegelglggp
      181 asppvppalp naavsileep qnrtsaysle hadlgagyyr kyfygkehqn ffgmdeslgp
      241 vavslrreek egsgggtlhs yrvivrttql rtlrgtised alppgpprgl sprkllehva
      301 pqlspsclrl gsaspkvprt lltldeqvls fqrkvgilyc ragqgseeem ynnqeagpaf
      361 mqfltllgdv vrlkgfesyr aqldtktdst gthslyttyq dheimfhvst mlpytpnnqq
      421 qllrkrhign divtivfqep gskpfcptti rshfqhvflv vrahtpctph ttyrvavsrt
      481 qdtpafgpal pagggpfaan adfrafllak alngeqaagh arqfhamatr trqqylqdla
      541 tnevtttsld sasrfglpsl ggrrraaprg pgaelqaags lvwgvraapg arvaagaqas
      601 gpegievpcl lgisaealvl vaprdgrvvf ncacrdvlaw tfseqqldly hgrgeaitlr
      661 fdgspgqavg evvarlqlvs rgcetrelal prdgqgrlgf evdaegfvth verftfaeta
      721 glrpgarllr vcgqtlpslr peaaaqllrs apkvcvtvlp pdesgrprrs fselytlslq
      781 epsrrgapdp vqdevqgvtl lpttkqllhl clqdggsppg pgdlaeerte flhsqnslsp
      841 rsslsdeapv lpnttpdlll attakpsvps adsetpltqd rpgspsgsed kgnpapelra
      901 sflprtlslr nsisrimsea gsgtledewq aiseiastcn tileslsreg qpipesgdpk
      961 gtpksdaepe pgnlsekvsh lesmlrklqe dlqkekadra aleeevrslr hnnrrlqaes
     1021 esaatrllla skqlgsptad la
//
LOCUS       XP_054225638            1042 aa            linear   PRI 05-AUG-2025
DEFINITION  signal-induced proliferation-associated protein 1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225638
VERSION     XP_054225638.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369663.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1042
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1042
                     /product="signal-induced proliferation-associated protein
                     1 isoform X1"
                     /calculated_mol_wt=112018
     Region          351..532
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     Region          687..759
                     /region_name="PDZ_SIPA1-like"
                     /note="PDZ domain of signal-induced
                     proliferation-associated protein 1 (SIPA1), and related
                     domains; cd06745"
                     /db_xref="CDD:467227"
     Site            order(697..703,709,712,741,745,748..749)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467227"
     Region          974..1030
                     /region_name="ZapB"
                     /note="Cell division protein ZapB; pfam06005"
                     /db_xref="CDD:428718"
     CDS             1..1042
                     /gene="SIPA1"
                     /gene_synonym="SPA1"
                     /coded_by="XM_054369663.1:1150..4278"
                     /db_xref="GeneID:6494"
                     /db_xref="HGNC:HGNC:10885"
                     /db_xref="MIM:602180"
ORIGIN      
        1 mpmwaggvgs prrgmapast ddlfarklrq parppltpht feprpvrgpl lrsgsdagea
       61 rpptpaspra rahsheeasr paatstrlft dplallglpa eepepafppv leprwfahyd
      121 vqsllfdwap rsqgmgshse assgtlasae dqaassdllh gapgfvcelg gegelglggp
      181 asppvppalp naavsileep qnrtsaysle hadlgagyyr kyfygkehqn ffgmdeslgp
      241 vavslrreek egsgggtlhs yrvivrttql rtlrgtised alppgpprgl sprkllehva
      301 pqlspsclrl gsaspkvprt lltldeqvls fqrkvgilyc ragqgseeem ynnqeagpaf
      361 mqfltllgdv vrlkgfesyr aqldtktdst gthslyttyq dheimfhvst mlpytpnnqq
      421 qllrkrhign divtivfqep gskpfcptti rshfqhvflv vrahtpctph ttyrvavsrt
      481 qdtpafgpal pagggpfaan adfrafllak alngeqaagh arqfhamatr trqqylqdla
      541 tnevtttsld sasrfglpsl ggrrraaprg pgaelqaags lvwgvraapg arvaagaqas
      601 gpegievpcl lgisaealvl vaprdgrvvf ncacrdvlaw tfseqqldly hgrgeaitlr
      661 fdgspgqavg evvarlqlvs rgcetrelal prdgqgrlgf evdaegfvth verftfaeta
      721 glrpgarllr vcgqtlpslr peaaaqllrs apkvcvtvlp pdesgrprrs fselytlslq
      781 epsrrgapdp vqdevqgvtl lpttkqllhl clqdggsppg pgdlaeerte flhsqnslsp
      841 rsslsdeapv lpnttpdlll attakpsvps adsetpltqd rpgspsgsed kgnpapelra
      901 sflprtlslr nsisrimsea gsgtledewq aiseiastcn tileslsreg qpipesgdpk
      961 gtpksdaepe pgnlsekvsh lesmlrklqe dlqkekadra aleeevrslr hnnrrlqaes
     1021 esaatrllla skqlgsptad la
//
LOCUS       XP_054225639            1042 aa            linear   PRI 05-AUG-2025
DEFINITION  signal-induced proliferation-associated protein 1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225639
VERSION     XP_054225639.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369664.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1042
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1042
                     /product="signal-induced proliferation-associated protein
                     1 isoform X1"
                     /calculated_mol_wt=112018
     Region          351..532
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     Region          687..759
                     /region_name="PDZ_SIPA1-like"
                     /note="PDZ domain of signal-induced
                     proliferation-associated protein 1 (SIPA1), and related
                     domains; cd06745"
                     /db_xref="CDD:467227"
     Site            order(697..703,709,712,741,745,748..749)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467227"
     Region          974..1030
                     /region_name="ZapB"
                     /note="Cell division protein ZapB; pfam06005"
                     /db_xref="CDD:428718"
     CDS             1..1042
                     /gene="SIPA1"
                     /gene_synonym="SPA1"
                     /coded_by="XM_054369664.1:744..3872"
                     /db_xref="GeneID:6494"
                     /db_xref="HGNC:HGNC:10885"
                     /db_xref="MIM:602180"
ORIGIN      
        1 mpmwaggvgs prrgmapast ddlfarklrq parppltpht feprpvrgpl lrsgsdagea
       61 rpptpaspra rahsheeasr paatstrlft dplallglpa eepepafppv leprwfahyd
      121 vqsllfdwap rsqgmgshse assgtlasae dqaassdllh gapgfvcelg gegelglggp
      181 asppvppalp naavsileep qnrtsaysle hadlgagyyr kyfygkehqn ffgmdeslgp
      241 vavslrreek egsgggtlhs yrvivrttql rtlrgtised alppgpprgl sprkllehva
      301 pqlspsclrl gsaspkvprt lltldeqvls fqrkvgilyc ragqgseeem ynnqeagpaf
      361 mqfltllgdv vrlkgfesyr aqldtktdst gthslyttyq dheimfhvst mlpytpnnqq
      421 qllrkrhign divtivfqep gskpfcptti rshfqhvflv vrahtpctph ttyrvavsrt
      481 qdtpafgpal pagggpfaan adfrafllak alngeqaagh arqfhamatr trqqylqdla
      541 tnevtttsld sasrfglpsl ggrrraaprg pgaelqaags lvwgvraapg arvaagaqas
      601 gpegievpcl lgisaealvl vaprdgrvvf ncacrdvlaw tfseqqldly hgrgeaitlr
      661 fdgspgqavg evvarlqlvs rgcetrelal prdgqgrlgf evdaegfvth verftfaeta
      721 glrpgarllr vcgqtlpslr peaaaqllrs apkvcvtvlp pdesgrprrs fselytlslq
      781 epsrrgapdp vqdevqgvtl lpttkqllhl clqdggsppg pgdlaeerte flhsqnslsp
      841 rsslsdeapv lpnttpdlll attakpsvps adsetpltqd rpgspsgsed kgnpapelra
      901 sflprtlslr nsisrimsea gsgtledewq aiseiastcn tileslsreg qpipesgdpk
      961 gtpksdaepe pgnlsekvsh lesmlrklqe dlqkekadra aleeevrslr hnnrrlqaes
     1021 esaatrllla skqlgsptad la
//
LOCUS       XP_054225640            1042 aa            linear   PRI 05-AUG-2025
DEFINITION  signal-induced proliferation-associated protein 1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225640
VERSION     XP_054225640.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369665.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1042
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1042
                     /product="signal-induced proliferation-associated protein
                     1 isoform X1"
                     /calculated_mol_wt=112018
     Region          351..532
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     Region          687..759
                     /region_name="PDZ_SIPA1-like"
                     /note="PDZ domain of signal-induced
                     proliferation-associated protein 1 (SIPA1), and related
                     domains; cd06745"
                     /db_xref="CDD:467227"
     Site            order(697..703,709,712,741,745,748..749)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467227"
     Region          974..1030
                     /region_name="ZapB"
                     /note="Cell division protein ZapB; pfam06005"
                     /db_xref="CDD:428718"
     CDS             1..1042
                     /gene="SIPA1"
                     /gene_synonym="SPA1"
                     /coded_by="XM_054369665.1:822..3950"
                     /db_xref="GeneID:6494"
                     /db_xref="HGNC:HGNC:10885"
                     /db_xref="MIM:602180"
ORIGIN      
        1 mpmwaggvgs prrgmapast ddlfarklrq parppltpht feprpvrgpl lrsgsdagea
       61 rpptpaspra rahsheeasr paatstrlft dplallglpa eepepafppv leprwfahyd
      121 vqsllfdwap rsqgmgshse assgtlasae dqaassdllh gapgfvcelg gegelglggp
      181 asppvppalp naavsileep qnrtsaysle hadlgagyyr kyfygkehqn ffgmdeslgp
      241 vavslrreek egsgggtlhs yrvivrttql rtlrgtised alppgpprgl sprkllehva
      301 pqlspsclrl gsaspkvprt lltldeqvls fqrkvgilyc ragqgseeem ynnqeagpaf
      361 mqfltllgdv vrlkgfesyr aqldtktdst gthslyttyq dheimfhvst mlpytpnnqq
      421 qllrkrhign divtivfqep gskpfcptti rshfqhvflv vrahtpctph ttyrvavsrt
      481 qdtpafgpal pagggpfaan adfrafllak alngeqaagh arqfhamatr trqqylqdla
      541 tnevtttsld sasrfglpsl ggrrraaprg pgaelqaags lvwgvraapg arvaagaqas
      601 gpegievpcl lgisaealvl vaprdgrvvf ncacrdvlaw tfseqqldly hgrgeaitlr
      661 fdgspgqavg evvarlqlvs rgcetrelal prdgqgrlgf evdaegfvth verftfaeta
      721 glrpgarllr vcgqtlpslr peaaaqllrs apkvcvtvlp pdesgrprrs fselytlslq
      781 epsrrgapdp vqdevqgvtl lpttkqllhl clqdggsppg pgdlaeerte flhsqnslsp
      841 rsslsdeapv lpnttpdlll attakpsvps adsetpltqd rpgspsgsed kgnpapelra
      901 sflprtlslr nsisrimsea gsgtledewq aiseiastcn tileslsreg qpipesgdpk
      961 gtpksdaepe pgnlsekvsh lesmlrklqe dlqkekadra aleeevrslr hnnrrlqaes
     1021 esaatrllla skqlgsptad la
//
LOCUS       XP_054225641            1042 aa            linear   PRI 05-AUG-2025
DEFINITION  signal-induced proliferation-associated protein 1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225641
VERSION     XP_054225641.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369666.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1042
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1042
                     /product="signal-induced proliferation-associated protein
                     1 isoform X1"
                     /calculated_mol_wt=112018
     Region          351..532
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     Region          687..759
                     /region_name="PDZ_SIPA1-like"
                     /note="PDZ domain of signal-induced
                     proliferation-associated protein 1 (SIPA1), and related
                     domains; cd06745"
                     /db_xref="CDD:467227"
     Site            order(697..703,709,712,741,745,748..749)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467227"
     Region          974..1030
                     /region_name="ZapB"
                     /note="Cell division protein ZapB; pfam06005"
                     /db_xref="CDD:428718"
     CDS             1..1042
                     /gene="SIPA1"
                     /gene_synonym="SPA1"
                     /coded_by="XM_054369666.1:377..3505"
                     /db_xref="GeneID:6494"
                     /db_xref="HGNC:HGNC:10885"
                     /db_xref="MIM:602180"
ORIGIN      
        1 mpmwaggvgs prrgmapast ddlfarklrq parppltpht feprpvrgpl lrsgsdagea
       61 rpptpaspra rahsheeasr paatstrlft dplallglpa eepepafppv leprwfahyd
      121 vqsllfdwap rsqgmgshse assgtlasae dqaassdllh gapgfvcelg gegelglggp
      181 asppvppalp naavsileep qnrtsaysle hadlgagyyr kyfygkehqn ffgmdeslgp
      241 vavslrreek egsgggtlhs yrvivrttql rtlrgtised alppgpprgl sprkllehva
      301 pqlspsclrl gsaspkvprt lltldeqvls fqrkvgilyc ragqgseeem ynnqeagpaf
      361 mqfltllgdv vrlkgfesyr aqldtktdst gthslyttyq dheimfhvst mlpytpnnqq
      421 qllrkrhign divtivfqep gskpfcptti rshfqhvflv vrahtpctph ttyrvavsrt
      481 qdtpafgpal pagggpfaan adfrafllak alngeqaagh arqfhamatr trqqylqdla
      541 tnevtttsld sasrfglpsl ggrrraaprg pgaelqaags lvwgvraapg arvaagaqas
      601 gpegievpcl lgisaealvl vaprdgrvvf ncacrdvlaw tfseqqldly hgrgeaitlr
      661 fdgspgqavg evvarlqlvs rgcetrelal prdgqgrlgf evdaegfvth verftfaeta
      721 glrpgarllr vcgqtlpslr peaaaqllrs apkvcvtvlp pdesgrprrs fselytlslq
      781 epsrrgapdp vqdevqgvtl lpttkqllhl clqdggsppg pgdlaeerte flhsqnslsp
      841 rsslsdeapv lpnttpdlll attakpsvps adsetpltqd rpgspsgsed kgnpapelra
      901 sflprtlslr nsisrimsea gsgtledewq aiseiastcn tileslsreg qpipesgdpk
      961 gtpksdaepe pgnlsekvsh lesmlrklqe dlqkekadra aleeevrslr hnnrrlqaes
     1021 esaatrllla skqlgsptad la
//
LOCUS       XP_054225642             789 aa            linear   PRI 05-AUG-2025
DEFINITION  signal-induced proliferation-associated protein 1 isoform X2 [Homo
            sapiens].
ACCESSION   XP_054225642
VERSION     XP_054225642.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369667.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..789
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..789
                     /product="signal-induced proliferation-associated protein
                     1 isoform X2"
                     /calculated_mol_wt=84823
     Region          <31..>114
                     /region_name="PHA03378"
                     /note="EBNA-3B; Provisional"
                     /db_xref="CDD:223065"
     Region          351..532
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     Region          687..759
                     /region_name="PDZ_SIPA1-like"
                     /note="PDZ domain of signal-induced
                     proliferation-associated protein 1 (SIPA1), and related
                     domains; cd06745"
                     /db_xref="CDD:467227"
     Site            order(697..703,709,712,741,745,748..749)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467227"
     CDS             1..789
                     /gene="SIPA1"
                     /gene_synonym="SPA1"
                     /coded_by="XM_054369667.1:122..2491"
                     /db_xref="GeneID:6494"
                     /db_xref="HGNC:HGNC:10885"
                     /db_xref="MIM:602180"
ORIGIN      
        1 mpmwaggvgs prrgmapast ddlfarklrq parppltpht feprpvrgpl lrsgsdagea
       61 rpptpaspra rahsheeasr paatstrlft dplallglpa eepepafppv leprwfahyd
      121 vqsllfdwap rsqgmgshse assgtlasae dqaassdllh gapgfvcelg gegelglggp
      181 asppvppalp naavsileep qnrtsaysle hadlgagyyr kyfygkehqn ffgmdeslgp
      241 vavslrreek egsgggtlhs yrvivrttql rtlrgtised alppgpprgl sprkllehva
      301 pqlspsclrl gsaspkvprt lltldeqvls fqrkvgilyc ragqgseeem ynnqeagpaf
      361 mqfltllgdv vrlkgfesyr aqldtktdst gthslyttyq dheimfhvst mlpytpnnqq
      421 qllrkrhign divtivfqep gskpfcptti rshfqhvflv vrahtpctph ttyrvavsrt
      481 qdtpafgpal pagggpfaan adfrafllak alngeqaagh arqfhamatr trqqylqdla
      541 tnevtttsld sasrfglpsl ggrrraaprg pgaelqaags lvwgvraapg arvaagaqas
      601 gpegievpcl lgisaealvl vaprdgrvvf ncacrdvlaw tfseqqldly hgrgeaitlr
      661 fdgspgqavg evvarlqlvs rgcetrelal prdgqgrlgf evdaegfvth verftfaeta
      721 glrpgarllr vcgqtlpslr peaaaqllrs apkvcvtvlp pdesgrprrp lgkrlpflsh
      781 pcspqlsvg
//
LOCUS       XP_054225643             766 aa            linear   PRI 05-AUG-2025
DEFINITION  signal-induced proliferation-associated protein 1 isoform X3 [Homo
            sapiens].
ACCESSION   XP_054225643
VERSION     XP_054225643.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369668.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..766
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..766
                     /product="signal-induced proliferation-associated protein
                     1 isoform X3"
                     /calculated_mol_wt=82173
     Region          <31..>114
                     /region_name="PHA03378"
                     /note="EBNA-3B; Provisional"
                     /db_xref="CDD:223065"
     Region          351..532
                     /region_name="Rap_GAP"
                     /note="Rap/ran-GAP; pfam02145"
                     /db_xref="CDD:460463"
     Region          687..753
                     /region_name="PDZ_SIPA1-like"
                     /note="PDZ domain of signal-induced
                     proliferation-associated protein 1 (SIPA1), and related
                     domains; cd06745"
                     /db_xref="CDD:467227"
     Site            order(697..703,709,712,741,745,748..749)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467227"
     CDS             1..766
                     /gene="SIPA1"
                     /gene_synonym="SPA1"
                     /coded_by="XM_054369668.1:122..2422"
                     /db_xref="GeneID:6494"
                     /db_xref="HGNC:HGNC:10885"
                     /db_xref="MIM:602180"
ORIGIN      
        1 mpmwaggvgs prrgmapast ddlfarklrq parppltpht feprpvrgpl lrsgsdagea
       61 rpptpaspra rahsheeasr paatstrlft dplallglpa eepepafppv leprwfahyd
      121 vqsllfdwap rsqgmgshse assgtlasae dqaassdllh gapgfvcelg gegelglggp
      181 asppvppalp naavsileep qnrtsaysle hadlgagyyr kyfygkehqn ffgmdeslgp
      241 vavslrreek egsgggtlhs yrvivrttql rtlrgtised alppgpprgl sprkllehva
      301 pqlspsclrl gsaspkvprt lltldeqvls fqrkvgilyc ragqgseeem ynnqeagpaf
      361 mqfltllgdv vrlkgfesyr aqldtktdst gthslyttyq dheimfhvst mlpytpnnqq
      421 qllrkrhign divtivfqep gskpfcptti rshfqhvflv vrahtpctph ttyrvavsrt
      481 qdtpafgpal pagggpfaan adfrafllak alngeqaagh arqfhamatr trqqylqdla
      541 tnevtttsld sasrfglpsl ggrrraaprg pgaelqaags lvwgvraapg arvaagaqas
      601 gpegievpcl lgisaealvl vaprdgrvvf ncacrdvlaw tfseqqldly hgrgeaitlr
      661 fdgspgqavg evvarlqlvs rgcetrelal prdgqgrlgf evdaegfvth verftfaeta
      721 glrpgarllr vcgqtlpslr peaaaqllrs apkeffgavh avaaga
//
LOCUS       XP_054225644             155 aa            linear   PRI 05-AUG-2025
DEFINITION  large ribosomal subunit protein uL11m isoform X1 [Homo sapiens].
ACCESSION   XP_054225644
VERSION     XP_054225644.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369669.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..155
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..155
                     /product="large ribosomal subunit protein uL11m isoform
                     X1"
                     /calculated_mol_wt=16845
     Region          16..129
                     /region_name="Ribosomal_L11"
                     /note="Ribosomal protein L11. Ribosomal protein L11,
                     together with proteins L10 and L7/L12, and 23S rRNA, form
                     the L7/L12 stalk on the surface of the large subunit of
                     the ribosome. The homologous eukaryotic cytoplasmic
                     protein is also called 60S ribosomal...; cd00349"
                     /db_xref="CDD:100101"
     Site            order(43,45..48,52,54..55,99..100,107..108)
                     /site_type="other"
                     /note="L7/L12 interface [polypeptide binding]"
                     /db_xref="CDD:100101"
     Site            order(60..62,66,73,98,107..109,113,116..117,120..121,
                     123..125)
                     /site_type="other"
                     /note="23S rRNA interface [nucleotide binding]"
                     /db_xref="CDD:100101"
     Site            order(79,82)
                     /site_type="other"
                     /note="L25 interface [polypeptide binding]"
                     /db_xref="CDD:100101"
     CDS             1..155
                     /gene="MRPL11"
                     /gene_synonym="CGI-113; L11MT; MRP-L11; uL11m"
                     /coded_by="XM_054369669.1:95..562"
                     /db_xref="GeneID:65003"
                     /db_xref="HGNC:HGNC:14042"
                     /db_xref="MIM:611826"
ORIGIN      
        1 msklgraarg lrkpergvsi nqfckefner tkdikegipl ptkilvkpdr tfeikigqpt
       61 vsyflkaaag iekgarqtgk evaglvtlkh vyeiarikaq deafalqdvp lssvvrsiig
      121 sarslgirvv kercsanvlr ngkismkdps grssv
//
LOCUS       XP_054225645             602 aa            linear   PRI 05-AUG-2025
DEFINITION  excitatory amino acid transporter 2 isoform X1 [Homo sapiens].
ACCESSION   XP_054225645
VERSION     XP_054225645.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369670.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..602
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..602
                     /product="excitatory amino acid transporter 2 isoform X1"
                     /calculated_mol_wt=65274
     Region          74..524
                     /region_name="SDF"
                     /note="Sodium:dicarboxylate symporter family; pfam00375"
                     /db_xref="CDD:425646"
     CDS             1..602
                     /gene="SLC1A2"
                     /gene_synonym="DEE41; EAAT2; EIEE41; GLT-1; GLT1; HBGT"
                     /coded_by="XM_054369670.1:489..2297"
                     /db_xref="GeneID:6506"
                     /db_xref="HGNC:HGNC:10940"
                     /db_xref="MIM:600300"
ORIGIN      
        1 mtavdrtvfd vfevktlark tlkqltafsl qyssannmpk qvevrmhdsh lgseepkhrh
       61 lglrlcdklg knllltltvf gvilgavcgg llrlaspihp dvvmliafpg dilmrmlkml
      121 ilpliissli tglsgldaka sgrlgtramv yymsttiiaa vlgvilvlai hpgnpklkkq
      181 lgpgkkndev ssldafldli rnlfpenlvq acfqqiqtvt kkvlvapppd eeanatsavv
      241 sllnetvtev peetkmvikk glefkdgmnv lgligffiaf giamgkmgdq aklmvdffni
      301 lneivmklvi mimwysplgi aclicgkiia ikdlevvarq lgmymvtvii gliihggifl
      361 pliyfvvtrk npfsffagif qawitalgta ssagtlpvtf rcleenlgid krvtrfvlpv
      421 gatinmdgta lyeavaaifi aqmngvvldg gqivtvslta tlasvgaasi psaglvtmll
      481 iltavglpte disllvavdw lldrmrtsvn vvgdsfgagi vyhlskseld tidsqhrvhe
      541 diemtktqsi yddmknhres nsnqcvyaah nsvivdeckv tlaangksad csveeepwkr
      601 ek
//
LOCUS       XP_054225646             572 aa            linear   PRI 05-AUG-2025
DEFINITION  excitatory amino acid transporter 2 isoform X2 [Homo sapiens].
ACCESSION   XP_054225646
VERSION     XP_054225646.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369671.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..572
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..572
                     /product="excitatory amino acid transporter 2 isoform X2"
                     /calculated_mol_wt=61829
     Region          44..494
                     /region_name="SDF"
                     /note="Sodium:dicarboxylate symporter family; pfam00375"
                     /db_xref="CDD:425646"
     CDS             1..572
                     /gene="SLC1A2"
                     /gene_synonym="DEE41; EAAT2; EIEE41; GLT-1; GLT1; HBGT"
                     /coded_by="XM_054369671.1:10..1728"
                     /db_xref="GeneID:6506"
                     /db_xref="HGNC:HGNC:10940"
                     /db_xref="MIM:600300"
ORIGIN      
        1 mitsannmpk qvevrmhdsh lgseepkhrh lglrlcdklg knllltltvf gvilgavcgg
       61 llrlaspihp dvvmliafpg dilmrmlkml ilpliissli tglsgldaka sgrlgtramv
      121 yymsttiiaa vlgvilvlai hpgnpklkkq lgpgkkndev ssldafldli rnlfpenlvq
      181 acfqqiqtvt kkvlvapppd eeanatsavv sllnetvtev peetkmvikk glefkdgmnv
      241 lgligffiaf giamgkmgdq aklmvdffni lneivmklvi mimwysplgi aclicgkiia
      301 ikdlevvarq lgmymvtvii gliihggifl pliyfvvtrk npfsffagif qawitalgta
      361 ssagtlpvtf rcleenlgid krvtrfvlpv gatinmdgta lyeavaaifi aqmngvvldg
      421 gqivtvslta tlasvgaasi psaglvtmll iltavglpte disllvavdw lldrmrtsvn
      481 vvgdsfgagi vyhlskseld tidsqhrvhe diemtktqsi yddmknhres nsnqcvyaah
      541 nsvivdeckv tlaangksad csveeepwkr ek
//
LOCUS       XP_054225647             579 aa            linear   PRI 05-AUG-2025
DEFINITION  excitatory amino acid transporter 2 isoform X3 [Homo sapiens].
ACCESSION   XP_054225647
VERSION     XP_054225647.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369672.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..579
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..579
                     /product="excitatory amino acid transporter 2 isoform X3"
                     /calculated_mol_wt=62833
     Region          51..501
                     /region_name="SDF"
                     /note="Sodium:dicarboxylate symporter family; pfam00375"
                     /db_xref="CDD:425646"
     CDS             1..579
                     /gene="SLC1A2"
                     /gene_synonym="DEE41; EAAT2; EIEE41; GLT-1; GLT1; HBGT"
                     /coded_by="XM_054369672.1:875..2614"
                     /db_xref="GeneID:6506"
                     /db_xref="HGNC:HGNC:10940"
                     /db_xref="MIM:600300"
ORIGIN      
        1 mkrpkdhiwr sannmpkqve vrmhdshlgs eepkhrhlgl rlcdklgknl lltltvfgvi
       61 lgavcggllr laspihpdvv mliafpgdil mrmlkmlilp liisslitgl sgldakasgr
      121 lgtramvyym sttiiaavlg vilvlaihpg npklkkqlgp gkkndevssl dafldlirnl
      181 fpenlvqacf qqiqtvtkkv lvapppdeea natsavvsll netvtevpee tkmvikkgle
      241 fkdgmnvlgl igffiafgia mgkmgdqakl mvdffnilne ivmklvimim wysplgiacl
      301 icgkiiaikd levvarqlgm ymvtviigli ihggiflpli yfvvtrknpf sffagifqaw
      361 italgtassa gtlpvtfrcl eenlgidkrv trfvlpvgat inmdgtalye avaaifiaqm
      421 ngvvldggqi vtvsltatla svgaasipsa glvtmllilt avglptedis llvavdwlld
      481 rmrtsvnvvg dsfgagivyh lskseldtid sqhrvhedie mtktqsiydd mknhresnsn
      541 qcvyaahnsv ivdeckvtla angksadcsv eeepwkrek
//
LOCUS       XP_054225649             565 aa            linear   PRI 05-AUG-2025
DEFINITION  excitatory amino acid transporter 2 isoform X5 [Homo sapiens].
ACCESSION   XP_054225649
VERSION     XP_054225649.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369674.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..565
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..565
                     /product="excitatory amino acid transporter 2 isoform X5"
                     /calculated_mol_wt=61097
     Region          37..487
                     /region_name="SDF"
                     /note="Sodium:dicarboxylate symporter family; pfam00375"
                     /db_xref="CDD:425646"
     CDS             1..565
                     /gene="SLC1A2"
                     /gene_synonym="DEE41; EAAT2; EIEE41; GLT-1; GLT1; HBGT"
                     /coded_by="XM_054369674.1:32..1729"
                     /db_xref="GeneID:6506"
                     /db_xref="HGNC:HGNC:10940"
                     /db_xref="MIM:600300"
ORIGIN      
        1 mpkqvevrmh dshlgseepk hrhlglrlcd klgknllltl tvfgvilgav cggllrlasp
       61 ihpdvvmlia fpgdilmrml kmlilpliis slitglsgld akasgrlgtr amvyymstti
      121 iaavlgvilv laihpgnpkl kkqlgpgkkn devssldafl dlirnlfpen lvqacfqqiq
      181 tvtkkvlvap ppdeeanats avvsllnetv tevpeetkmv ikkglefkdg mnvlgligff
      241 iafgiamgkm gdqaklmvdf fnilneivmk lvimimwysp lgiaclicgk iiaikdlevv
      301 arqlgmymvt viigliihgg iflpliyfvv trknpfsffa gifqawital gtassagtlp
      361 vtfrcleenl gidkrvtrfv lpvgatinmd gtalyeavaa ifiaqmngvv ldggqivtvs
      421 ltatlasvga asipsaglvt mlliltavgl ptedisllva vdwlldrmrt svnvvgdsfg
      481 agivyhlsks eldtidsqhr vhediemtkt qsiyddmknh resnsnqcvy aahnsvivde
      541 ckvtlaangk sadcsveeep wkrek
//
LOCUS       XP_054225651             565 aa            linear   PRI 05-AUG-2025
DEFINITION  excitatory amino acid transporter 2 isoform X5 [Homo sapiens].
ACCESSION   XP_054225651
VERSION     XP_054225651.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369676.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..565
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..565
                     /product="excitatory amino acid transporter 2 isoform X5"
                     /calculated_mol_wt=61097
     Region          37..487
                     /region_name="SDF"
                     /note="Sodium:dicarboxylate symporter family; pfam00375"
                     /db_xref="CDD:425646"
     CDS             1..565
                     /gene="SLC1A2"
                     /gene_synonym="DEE41; EAAT2; EIEE41; GLT-1; GLT1; HBGT"
                     /coded_by="XM_054369676.1:30..1727"
                     /db_xref="GeneID:6506"
                     /db_xref="HGNC:HGNC:10940"
                     /db_xref="MIM:600300"
ORIGIN      
        1 mpkqvevrmh dshlgseepk hrhlglrlcd klgknllltl tvfgvilgav cggllrlasp
       61 ihpdvvmlia fpgdilmrml kmlilpliis slitglsgld akasgrlgtr amvyymstti
      121 iaavlgvilv laihpgnpkl kkqlgpgkkn devssldafl dlirnlfpen lvqacfqqiq
      181 tvtkkvlvap ppdeeanats avvsllnetv tevpeetkmv ikkglefkdg mnvlgligff
      241 iafgiamgkm gdqaklmvdf fnilneivmk lvimimwysp lgiaclicgk iiaikdlevv
      301 arqlgmymvt viigliihgg iflpliyfvv trknpfsffa gifqawital gtassagtlp
      361 vtfrcleenl gidkrvtrfv lpvgatinmd gtalyeavaa ifiaqmngvv ldggqivtvs
      421 ltatlasvga asipsaglvt mlliltavgl ptedisllva vdwlldrmrt svnvvgdsfg
      481 agivyhlsks eldtidsqhr vhediemtkt qsiyddmknh resnsnqcvy aahnsvivde
      541 ckvtlaangk sadcsveeep wkrek
//
LOCUS       XP_054225652             565 aa            linear   PRI 05-AUG-2025
DEFINITION  excitatory amino acid transporter 2 isoform X5 [Homo sapiens].
ACCESSION   XP_054225652
VERSION     XP_054225652.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369677.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..565
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..565
                     /product="excitatory amino acid transporter 2 isoform X5"
                     /calculated_mol_wt=61097
     Region          37..487
                     /region_name="SDF"
                     /note="Sodium:dicarboxylate symporter family; pfam00375"
                     /db_xref="CDD:425646"
     CDS             1..565
                     /gene="SLC1A2"
                     /gene_synonym="DEE41; EAAT2; EIEE41; GLT-1; GLT1; HBGT"
                     /coded_by="XM_054369677.1:29..1726"
                     /db_xref="GeneID:6506"
                     /db_xref="HGNC:HGNC:10940"
                     /db_xref="MIM:600300"
ORIGIN      
        1 mpkqvevrmh dshlgseepk hrhlglrlcd klgknllltl tvfgvilgav cggllrlasp
       61 ihpdvvmlia fpgdilmrml kmlilpliis slitglsgld akasgrlgtr amvyymstti
      121 iaavlgvilv laihpgnpkl kkqlgpgkkn devssldafl dlirnlfpen lvqacfqqiq
      181 tvtkkvlvap ppdeeanats avvsllnetv tevpeetkmv ikkglefkdg mnvlgligff
      241 iafgiamgkm gdqaklmvdf fnilneivmk lvimimwysp lgiaclicgk iiaikdlevv
      301 arqlgmymvt viigliihgg iflpliyfvv trknpfsffa gifqawital gtassagtlp
      361 vtfrcleenl gidkrvtrfv lpvgatinmd gtalyeavaa ifiaqmngvv ldggqivtvs
      421 ltatlasvga asipsaglvt mlliltavgl ptedisllva vdwlldrmrt svnvvgdsfg
      481 agivyhlsks eldtidsqhr vhediemtkt qsiyddmknh resnsnqcvy aahnsvivde
      541 ckvtlaangk sadcsveeep wkrek
//
LOCUS       XP_054225654             565 aa            linear   PRI 05-AUG-2025
DEFINITION  excitatory amino acid transporter 2 isoform X5 [Homo sapiens].
ACCESSION   XP_054225654
VERSION     XP_054225654.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369679.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..565
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..565
                     /product="excitatory amino acid transporter 2 isoform X5"
                     /calculated_mol_wt=61097
     Region          37..487
                     /region_name="SDF"
                     /note="Sodium:dicarboxylate symporter family; pfam00375"
                     /db_xref="CDD:425646"
     CDS             1..565
                     /gene="SLC1A2"
                     /gene_synonym="DEE41; EAAT2; EIEE41; GLT-1; GLT1; HBGT"
                     /coded_by="XM_054369679.1:265..1962"
                     /db_xref="GeneID:6506"
                     /db_xref="HGNC:HGNC:10940"
                     /db_xref="MIM:600300"
ORIGIN      
        1 mpkqvevrmh dshlgseepk hrhlglrlcd klgknllltl tvfgvilgav cggllrlasp
       61 ihpdvvmlia fpgdilmrml kmlilpliis slitglsgld akasgrlgtr amvyymstti
      121 iaavlgvilv laihpgnpkl kkqlgpgkkn devssldafl dlirnlfpen lvqacfqqiq
      181 tvtkkvlvap ppdeeanats avvsllnetv tevpeetkmv ikkglefkdg mnvlgligff
      241 iafgiamgkm gdqaklmvdf fnilneivmk lvimimwysp lgiaclicgk iiaikdlevv
      301 arqlgmymvt viigliihgg iflpliyfvv trknpfsffa gifqawital gtassagtlp
      361 vtfrcleenl gidkrvtrfv lpvgatinmd gtalyeavaa ifiaqmngvv ldggqivtvs
      421 ltatlasvga asipsaglvt mlliltavgl ptedisllva vdwlldrmrt svnvvgdsfg
      481 agivyhlsks eldtidsqhr vhediemtkt qsiyddmknh resnsnqcvy aahnsvivde
      541 ckvtlaangk sadcsveeep wkrek
//
LOCUS       XP_054225655             565 aa            linear   PRI 05-AUG-2025
DEFINITION  excitatory amino acid transporter 2 isoform X5 [Homo sapiens].
ACCESSION   XP_054225655
VERSION     XP_054225655.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369680.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..565
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..565
                     /product="excitatory amino acid transporter 2 isoform X5"
                     /calculated_mol_wt=61097
     Region          37..487
                     /region_name="SDF"
                     /note="Sodium:dicarboxylate symporter family; pfam00375"
                     /db_xref="CDD:425646"
     CDS             1..565
                     /gene="SLC1A2"
                     /gene_synonym="DEE41; EAAT2; EIEE41; GLT-1; GLT1; HBGT"
                     /coded_by="XM_054369680.1:32..1729"
                     /db_xref="GeneID:6506"
                     /db_xref="HGNC:HGNC:10940"
                     /db_xref="MIM:600300"
ORIGIN      
        1 mpkqvevrmh dshlgseepk hrhlglrlcd klgknllltl tvfgvilgav cggllrlasp
       61 ihpdvvmlia fpgdilmrml kmlilpliis slitglsgld akasgrlgtr amvyymstti
      121 iaavlgvilv laihpgnpkl kkqlgpgkkn devssldafl dlirnlfpen lvqacfqqiq
      181 tvtkkvlvap ppdeeanats avvsllnetv tevpeetkmv ikkglefkdg mnvlgligff
      241 iafgiamgkm gdqaklmvdf fnilneivmk lvimimwysp lgiaclicgk iiaikdlevv
      301 arqlgmymvt viigliihgg iflpliyfvv trknpfsffa gifqawital gtassagtlp
      361 vtfrcleenl gidkrvtrfv lpvgatinmd gtalyeavaa ifiaqmngvv ldggqivtvs
      421 ltatlasvga asipsaglvt mlliltavgl ptedisllva vdwlldrmrt svnvvgdsfg
      481 agivyhlsks eldtidsqhr vhediemtkt qsiyddmknh resnsnqcvy aahnsvivde
      541 ckvtlaangk sadcsveeep wkrek
//
LOCUS       XP_054225656             330 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 135 isoform X1 [Homo sapiens].
ACCESSION   XP_054225656
VERSION     XP_054225656.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369681.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..330
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..330
                     /product="transmembrane protein 135 isoform X1"
                     /calculated_mol_wt=37821
     Region          <171..223
                     /region_name="Tim17"
                     /note="Tim17/Tim22/Tim23/Pmp24 family; pfam02466"
                     /db_xref="CDD:460567"
     CDS             1..330
                     /gene="TMEM135"
                     /gene_synonym="PMP52"
                     /coded_by="XM_054369681.1:137..1129"
                     /db_xref="GeneID:65084"
                     /db_xref="HGNC:HGNC:26167"
                     /db_xref="MIM:616360"
ORIGIN      
        1 manlatetlf rmgvargtit tlrngevllf citaamymff frckdglkgf tfsalrfivg
       61 keeipthsfs peaayakveq kreqheekpr rmnmiglvrk fvdsickhgp rhrcckhyed
      121 ncisycikgf irmfsvgyli qcclripsaf rhlftqpsrl lslfynkenf qlgaflgsfv
      181 siykgtscfl rwirnlddel haiiagflag ismmfykstt ismylasklv etmyfkgiea
      241 gkvpyfphad tiiysistai cfqaavmevq tlrpsywkfl lrltkgkfav mnrkvldvfg
      301 tgaskhfqdf iprldprytt vtpelptefs
//
LOCUS       XP_054225657             319 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 135 isoform X2 [Homo sapiens].
ACCESSION   XP_054225657
VERSION     XP_054225657.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369682.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..319
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..319
                     /product="transmembrane protein 135 isoform X2"
                     /calculated_mol_wt=36572
     Region          <160..212
                     /region_name="Tim17"
                     /note="Tim17/Tim22/Tim23/Pmp24 family; pfam02466"
                     /db_xref="CDD:460567"
     CDS             1..319
                     /gene="TMEM135"
                     /gene_synonym="PMP52"
                     /coded_by="XM_054369682.1:43..1002"
                     /db_xref="GeneID:65084"
                     /db_xref="HGNC:HGNC:26167"
                     /db_xref="MIM:616360"
ORIGIN      
        1 mgvargtitt lrngevllfc itaamymfff rckdglkgft fsalrfivgk eeipthsfsp
       61 eaayakveqk reqheekprr mnmiglvrkf vdsickhgpr hrcckhyedn cisycikgfi
      121 rmfsvgyliq cclripsafr hlftqpsrll slfynkenfq lgaflgsfvs iykgtscflr
      181 wirnlddelh aiiagflagi smmfykstti smylasklve tmyfkgieag kvpyfphadt
      241 iiysistaic fqaavmevqt lrpsywkfll rltkgkfavm nrkvldvfgt gaskhfqdfi
      301 prldpryttv tpelptefs
//
LOCUS       XP_054225658             514 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase 33 isoform X1 [Homo sapiens].
ACCESSION   XP_054225658
VERSION     XP_054225658.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369683.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..514
                     /product="serine/threonine-protein kinase 33 isoform X1"
                     /calculated_mol_wt=57700
     Region          114..381
                     /region_name="STKc_STK33"
                     /note="Catalytic domain of Serine/Threonine Kinase 33;
                     cd14097"
                     /db_xref="CDD:270999"
     Site            order(122..126,130,143,145,176,192..195,199,201,237..238,
                     240,242..243,245,264..265,268,284..288,290)
                     /site_type="active"
                     /db_xref="CDD:270999"
     Site            order(122..125,130,143,145,176,192..195,199,242..243,245,
                     264..265)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270999"
     Site            order(126,199,201,237..238,240,242,268,284..288,290)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270999"
     Site            order(264..278,280..288)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270999"
     CDS             1..514
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /coded_by="XM_054369683.1:699..2243"
                     /db_xref="GeneID:65975"
                     /db_xref="HGNC:HGNC:14568"
                     /db_xref="MIM:607670"
ORIGIN      
        1 madsgldkks tkcpdcssas qkdvlcvcss ktrvppvlvv emsqtssigs aeslislerk
       61 kekninrdit srkdlpsrts nverkasqqq wgrgnftegk vphirienga aieeiytfgr
      121 ilgkgsfgiv ieatdketet kwaikkvnke kagssavkll erevnilksv khehiihleq
      181 vfetpkkmyl vmelcedgel keildrkghf senetrwiiq slasaiaylh nndivhrdlk
      241 lenimvkssl iddnneinln ikvtdfglav kkqsrseaml qatcgtpiym apevisahdy
      301 sqqcdiwsig vvmymllrge ppflasseek lfelirkgel hfenavwnsi sdcaksvlkq
      361 lmkvdpahri takelldnqw ltgnklssvr ptnvlemmke wknnpesvee ntteeknkps
      421 teeklksyqp wgnvpdanyt sdeeeekqst ayekqfpats kdnfdmcsss ftsskllpae
      481 ikgemektpv tpsqgtatky paksgalsrt kkkl
//
LOCUS       XP_054225659             514 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase 33 isoform X1 [Homo sapiens].
ACCESSION   XP_054225659
VERSION     XP_054225659.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369684.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..514
                     /product="serine/threonine-protein kinase 33 isoform X1"
                     /calculated_mol_wt=57700
     Region          114..381
                     /region_name="STKc_STK33"
                     /note="Catalytic domain of Serine/Threonine Kinase 33;
                     cd14097"
                     /db_xref="CDD:270999"
     Site            order(122..126,130,143,145,176,192..195,199,201,237..238,
                     240,242..243,245,264..265,268,284..288,290)
                     /site_type="active"
                     /db_xref="CDD:270999"
     Site            order(122..125,130,143,145,176,192..195,199,242..243,245,
                     264..265)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270999"
     Site            order(126,199,201,237..238,240,242,268,284..288,290)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270999"
     Site            order(264..278,280..288)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270999"
     CDS             1..514
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /coded_by="XM_054369684.1:626..2170"
                     /db_xref="GeneID:65975"
                     /db_xref="HGNC:HGNC:14568"
                     /db_xref="MIM:607670"
ORIGIN      
        1 madsgldkks tkcpdcssas qkdvlcvcss ktrvppvlvv emsqtssigs aeslislerk
       61 kekninrdit srkdlpsrts nverkasqqq wgrgnftegk vphirienga aieeiytfgr
      121 ilgkgsfgiv ieatdketet kwaikkvnke kagssavkll erevnilksv khehiihleq
      181 vfetpkkmyl vmelcedgel keildrkghf senetrwiiq slasaiaylh nndivhrdlk
      241 lenimvkssl iddnneinln ikvtdfglav kkqsrseaml qatcgtpiym apevisahdy
      301 sqqcdiwsig vvmymllrge ppflasseek lfelirkgel hfenavwnsi sdcaksvlkq
      361 lmkvdpahri takelldnqw ltgnklssvr ptnvlemmke wknnpesvee ntteeknkps
      421 teeklksyqp wgnvpdanyt sdeeeekqst ayekqfpats kdnfdmcsss ftsskllpae
      481 ikgemektpv tpsqgtatky paksgalsrt kkkl
//
LOCUS       XP_054225660             514 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase 33 isoform X1 [Homo sapiens].
ACCESSION   XP_054225660
VERSION     XP_054225660.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369685.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..514
                     /product="serine/threonine-protein kinase 33 isoform X1"
                     /calculated_mol_wt=57700
     Region          114..381
                     /region_name="STKc_STK33"
                     /note="Catalytic domain of Serine/Threonine Kinase 33;
                     cd14097"
                     /db_xref="CDD:270999"
     Site            order(122..126,130,143,145,176,192..195,199,201,237..238,
                     240,242..243,245,264..265,268,284..288,290)
                     /site_type="active"
                     /db_xref="CDD:270999"
     Site            order(122..125,130,143,145,176,192..195,199,242..243,245,
                     264..265)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270999"
     Site            order(126,199,201,237..238,240,242,268,284..288,290)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270999"
     Site            order(264..278,280..288)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270999"
     CDS             1..514
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /coded_by="XM_054369685.1:702..2246"
                     /db_xref="GeneID:65975"
                     /db_xref="HGNC:HGNC:14568"
                     /db_xref="MIM:607670"
ORIGIN      
        1 madsgldkks tkcpdcssas qkdvlcvcss ktrvppvlvv emsqtssigs aeslislerk
       61 kekninrdit srkdlpsrts nverkasqqq wgrgnftegk vphirienga aieeiytfgr
      121 ilgkgsfgiv ieatdketet kwaikkvnke kagssavkll erevnilksv khehiihleq
      181 vfetpkkmyl vmelcedgel keildrkghf senetrwiiq slasaiaylh nndivhrdlk
      241 lenimvkssl iddnneinln ikvtdfglav kkqsrseaml qatcgtpiym apevisahdy
      301 sqqcdiwsig vvmymllrge ppflasseek lfelirkgel hfenavwnsi sdcaksvlkq
      361 lmkvdpahri takelldnqw ltgnklssvr ptnvlemmke wknnpesvee ntteeknkps
      421 teeklksyqp wgnvpdanyt sdeeeekqst ayekqfpats kdnfdmcsss ftsskllpae
      481 ikgemektpv tpsqgtatky paksgalsrt kkkl
//
LOCUS       XP_054225661             514 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase 33 isoform X1 [Homo sapiens].
ACCESSION   XP_054225661
VERSION     XP_054225661.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369686.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..514
                     /product="serine/threonine-protein kinase 33 isoform X1"
                     /calculated_mol_wt=57700
     Region          114..381
                     /region_name="STKc_STK33"
                     /note="Catalytic domain of Serine/Threonine Kinase 33;
                     cd14097"
                     /db_xref="CDD:270999"
     Site            order(122..126,130,143,145,176,192..195,199,201,237..238,
                     240,242..243,245,264..265,268,284..288,290)
                     /site_type="active"
                     /db_xref="CDD:270999"
     Site            order(122..125,130,143,145,176,192..195,199,242..243,245,
                     264..265)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270999"
     Site            order(126,199,201,237..238,240,242,268,284..288,290)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270999"
     Site            order(264..278,280..288)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270999"
     CDS             1..514
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /coded_by="XM_054369686.1:488..2032"
                     /db_xref="GeneID:65975"
                     /db_xref="HGNC:HGNC:14568"
                     /db_xref="MIM:607670"
ORIGIN      
        1 madsgldkks tkcpdcssas qkdvlcvcss ktrvppvlvv emsqtssigs aeslislerk
       61 kekninrdit srkdlpsrts nverkasqqq wgrgnftegk vphirienga aieeiytfgr
      121 ilgkgsfgiv ieatdketet kwaikkvnke kagssavkll erevnilksv khehiihleq
      181 vfetpkkmyl vmelcedgel keildrkghf senetrwiiq slasaiaylh nndivhrdlk
      241 lenimvkssl iddnneinln ikvtdfglav kkqsrseaml qatcgtpiym apevisahdy
      301 sqqcdiwsig vvmymllrge ppflasseek lfelirkgel hfenavwnsi sdcaksvlkq
      361 lmkvdpahri takelldnqw ltgnklssvr ptnvlemmke wknnpesvee ntteeknkps
      421 teeklksyqp wgnvpdanyt sdeeeekqst ayekqfpats kdnfdmcsss ftsskllpae
      481 ikgemektpv tpsqgtatky paksgalsrt kkkl
//
LOCUS       XP_054225662             514 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase 33 isoform X1 [Homo sapiens].
ACCESSION   XP_054225662
VERSION     XP_054225662.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369687.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..514
                     /product="serine/threonine-protein kinase 33 isoform X1"
                     /calculated_mol_wt=57700
     Region          114..381
                     /region_name="STKc_STK33"
                     /note="Catalytic domain of Serine/Threonine Kinase 33;
                     cd14097"
                     /db_xref="CDD:270999"
     Site            order(122..126,130,143,145,176,192..195,199,201,237..238,
                     240,242..243,245,264..265,268,284..288,290)
                     /site_type="active"
                     /db_xref="CDD:270999"
     Site            order(122..125,130,143,145,176,192..195,199,242..243,245,
                     264..265)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270999"
     Site            order(126,199,201,237..238,240,242,268,284..288,290)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270999"
     Site            order(264..278,280..288)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270999"
     CDS             1..514
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /coded_by="XM_054369687.1:474..2018"
                     /db_xref="GeneID:65975"
                     /db_xref="HGNC:HGNC:14568"
                     /db_xref="MIM:607670"
ORIGIN      
        1 madsgldkks tkcpdcssas qkdvlcvcss ktrvppvlvv emsqtssigs aeslislerk
       61 kekninrdit srkdlpsrts nverkasqqq wgrgnftegk vphirienga aieeiytfgr
      121 ilgkgsfgiv ieatdketet kwaikkvnke kagssavkll erevnilksv khehiihleq
      181 vfetpkkmyl vmelcedgel keildrkghf senetrwiiq slasaiaylh nndivhrdlk
      241 lenimvkssl iddnneinln ikvtdfglav kkqsrseaml qatcgtpiym apevisahdy
      301 sqqcdiwsig vvmymllrge ppflasseek lfelirkgel hfenavwnsi sdcaksvlkq
      361 lmkvdpahri takelldnqw ltgnklssvr ptnvlemmke wknnpesvee ntteeknkps
      421 teeklksyqp wgnvpdanyt sdeeeekqst ayekqfpats kdnfdmcsss ftsskllpae
      481 ikgemektpv tpsqgtatky paksgalsrt kkkl
//
LOCUS       XP_054225663             514 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase 33 isoform X1 [Homo sapiens].
ACCESSION   XP_054225663
VERSION     XP_054225663.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369688.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..514
                     /product="serine/threonine-protein kinase 33 isoform X1"
                     /calculated_mol_wt=57700
     Region          114..381
                     /region_name="STKc_STK33"
                     /note="Catalytic domain of Serine/Threonine Kinase 33;
                     cd14097"
                     /db_xref="CDD:270999"
     Site            order(122..126,130,143,145,176,192..195,199,201,237..238,
                     240,242..243,245,264..265,268,284..288,290)
                     /site_type="active"
                     /db_xref="CDD:270999"
     Site            order(122..125,130,143,145,176,192..195,199,242..243,245,
                     264..265)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270999"
     Site            order(126,199,201,237..238,240,242,268,284..288,290)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270999"
     Site            order(264..278,280..288)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270999"
     CDS             1..514
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /coded_by="XM_054369688.1:615..2159"
                     /db_xref="GeneID:65975"
                     /db_xref="HGNC:HGNC:14568"
                     /db_xref="MIM:607670"
ORIGIN      
        1 madsgldkks tkcpdcssas qkdvlcvcss ktrvppvlvv emsqtssigs aeslislerk
       61 kekninrdit srkdlpsrts nverkasqqq wgrgnftegk vphirienga aieeiytfgr
      121 ilgkgsfgiv ieatdketet kwaikkvnke kagssavkll erevnilksv khehiihleq
      181 vfetpkkmyl vmelcedgel keildrkghf senetrwiiq slasaiaylh nndivhrdlk
      241 lenimvkssl iddnneinln ikvtdfglav kkqsrseaml qatcgtpiym apevisahdy
      301 sqqcdiwsig vvmymllrge ppflasseek lfelirkgel hfenavwnsi sdcaksvlkq
      361 lmkvdpahri takelldnqw ltgnklssvr ptnvlemmke wknnpesvee ntteeknkps
      421 teeklksyqp wgnvpdanyt sdeeeekqst ayekqfpats kdnfdmcsss ftsskllpae
      481 ikgemektpv tpsqgtatky paksgalsrt kkkl
//
LOCUS       XP_054225664             514 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase 33 isoform X1 [Homo sapiens].
ACCESSION   XP_054225664
VERSION     XP_054225664.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369689.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..514
                     /product="serine/threonine-protein kinase 33 isoform X1"
                     /calculated_mol_wt=57700
     Region          114..381
                     /region_name="STKc_STK33"
                     /note="Catalytic domain of Serine/Threonine Kinase 33;
                     cd14097"
                     /db_xref="CDD:270999"
     Site            order(122..126,130,143,145,176,192..195,199,201,237..238,
                     240,242..243,245,264..265,268,284..288,290)
                     /site_type="active"
                     /db_xref="CDD:270999"
     Site            order(122..125,130,143,145,176,192..195,199,242..243,245,
                     264..265)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270999"
     Site            order(126,199,201,237..238,240,242,268,284..288,290)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270999"
     Site            order(264..278,280..288)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270999"
     CDS             1..514
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /coded_by="XM_054369689.1:513..2057"
                     /db_xref="GeneID:65975"
                     /db_xref="HGNC:HGNC:14568"
                     /db_xref="MIM:607670"
ORIGIN      
        1 madsgldkks tkcpdcssas qkdvlcvcss ktrvppvlvv emsqtssigs aeslislerk
       61 kekninrdit srkdlpsrts nverkasqqq wgrgnftegk vphirienga aieeiytfgr
      121 ilgkgsfgiv ieatdketet kwaikkvnke kagssavkll erevnilksv khehiihleq
      181 vfetpkkmyl vmelcedgel keildrkghf senetrwiiq slasaiaylh nndivhrdlk
      241 lenimvkssl iddnneinln ikvtdfglav kkqsrseaml qatcgtpiym apevisahdy
      301 sqqcdiwsig vvmymllrge ppflasseek lfelirkgel hfenavwnsi sdcaksvlkq
      361 lmkvdpahri takelldnqw ltgnklssvr ptnvlemmke wknnpesvee ntteeknkps
      421 teeklksyqp wgnvpdanyt sdeeeekqst ayekqfpats kdnfdmcsss ftsskllpae
      481 ikgemektpv tpsqgtatky paksgalsrt kkkl
//
LOCUS       XP_054225665             514 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase 33 isoform X1 [Homo sapiens].
ACCESSION   XP_054225665
VERSION     XP_054225665.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369690.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..514
                     /product="serine/threonine-protein kinase 33 isoform X1"
                     /calculated_mol_wt=57700
     Region          114..381
                     /region_name="STKc_STK33"
                     /note="Catalytic domain of Serine/Threonine Kinase 33;
                     cd14097"
                     /db_xref="CDD:270999"
     Site            order(122..126,130,143,145,176,192..195,199,201,237..238,
                     240,242..243,245,264..265,268,284..288,290)
                     /site_type="active"
                     /db_xref="CDD:270999"
     Site            order(122..125,130,143,145,176,192..195,199,242..243,245,
                     264..265)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270999"
     Site            order(126,199,201,237..238,240,242,268,284..288,290)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270999"
     Site            order(264..278,280..288)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270999"
     CDS             1..514
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /coded_by="XM_054369690.1:491..2035"
                     /db_xref="GeneID:65975"
                     /db_xref="HGNC:HGNC:14568"
                     /db_xref="MIM:607670"
ORIGIN      
        1 madsgldkks tkcpdcssas qkdvlcvcss ktrvppvlvv emsqtssigs aeslislerk
       61 kekninrdit srkdlpsrts nverkasqqq wgrgnftegk vphirienga aieeiytfgr
      121 ilgkgsfgiv ieatdketet kwaikkvnke kagssavkll erevnilksv khehiihleq
      181 vfetpkkmyl vmelcedgel keildrkghf senetrwiiq slasaiaylh nndivhrdlk
      241 lenimvkssl iddnneinln ikvtdfglav kkqsrseaml qatcgtpiym apevisahdy
      301 sqqcdiwsig vvmymllrge ppflasseek lfelirkgel hfenavwnsi sdcaksvlkq
      361 lmkvdpahri takelldnqw ltgnklssvr ptnvlemmke wknnpesvee ntteeknkps
      421 teeklksyqp wgnvpdanyt sdeeeekqst ayekqfpats kdnfdmcsss ftsskllpae
      481 ikgemektpv tpsqgtatky paksgalsrt kkkl
//
LOCUS       XP_054225666             514 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase 33 isoform X1 [Homo sapiens].
ACCESSION   XP_054225666
VERSION     XP_054225666.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369691.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..514
                     /product="serine/threonine-protein kinase 33 isoform X1"
                     /calculated_mol_wt=57700
     Region          114..381
                     /region_name="STKc_STK33"
                     /note="Catalytic domain of Serine/Threonine Kinase 33;
                     cd14097"
                     /db_xref="CDD:270999"
     Site            order(122..126,130,143,145,176,192..195,199,201,237..238,
                     240,242..243,245,264..265,268,284..288,290)
                     /site_type="active"
                     /db_xref="CDD:270999"
     Site            order(122..125,130,143,145,176,192..195,199,242..243,245,
                     264..265)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270999"
     Site            order(126,199,201,237..238,240,242,268,284..288,290)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270999"
     Site            order(264..278,280..288)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270999"
     CDS             1..514
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /coded_by="XM_054369691.1:600..2144"
                     /db_xref="GeneID:65975"
                     /db_xref="HGNC:HGNC:14568"
                     /db_xref="MIM:607670"
ORIGIN      
        1 madsgldkks tkcpdcssas qkdvlcvcss ktrvppvlvv emsqtssigs aeslislerk
       61 kekninrdit srkdlpsrts nverkasqqq wgrgnftegk vphirienga aieeiytfgr
      121 ilgkgsfgiv ieatdketet kwaikkvnke kagssavkll erevnilksv khehiihleq
      181 vfetpkkmyl vmelcedgel keildrkghf senetrwiiq slasaiaylh nndivhrdlk
      241 lenimvkssl iddnneinln ikvtdfglav kkqsrseaml qatcgtpiym apevisahdy
      301 sqqcdiwsig vvmymllrge ppflasseek lfelirkgel hfenavwnsi sdcaksvlkq
      361 lmkvdpahri takelldnqw ltgnklssvr ptnvlemmke wknnpesvee ntteeknkps
      421 teeklksyqp wgnvpdanyt sdeeeekqst ayekqfpats kdnfdmcsss ftsskllpae
      481 ikgemektpv tpsqgtatky paksgalsrt kkkl
//
LOCUS       XP_054225667             514 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase 33 isoform X1 [Homo sapiens].
ACCESSION   XP_054225667
VERSION     XP_054225667.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369692.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..514
                     /product="serine/threonine-protein kinase 33 isoform X1"
                     /calculated_mol_wt=57700
     Region          114..381
                     /region_name="STKc_STK33"
                     /note="Catalytic domain of Serine/Threonine Kinase 33;
                     cd14097"
                     /db_xref="CDD:270999"
     Site            order(122..126,130,143,145,176,192..195,199,201,237..238,
                     240,242..243,245,264..265,268,284..288,290)
                     /site_type="active"
                     /db_xref="CDD:270999"
     Site            order(122..125,130,143,145,176,192..195,199,242..243,245,
                     264..265)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270999"
     Site            order(126,199,201,237..238,240,242,268,284..288,290)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270999"
     Site            order(264..278,280..288)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270999"
     CDS             1..514
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /coded_by="XM_054369692.1:494..2038"
                     /db_xref="GeneID:65975"
                     /db_xref="HGNC:HGNC:14568"
                     /db_xref="MIM:607670"
ORIGIN      
        1 madsgldkks tkcpdcssas qkdvlcvcss ktrvppvlvv emsqtssigs aeslislerk
       61 kekninrdit srkdlpsrts nverkasqqq wgrgnftegk vphirienga aieeiytfgr
      121 ilgkgsfgiv ieatdketet kwaikkvnke kagssavkll erevnilksv khehiihleq
      181 vfetpkkmyl vmelcedgel keildrkghf senetrwiiq slasaiaylh nndivhrdlk
      241 lenimvkssl iddnneinln ikvtdfglav kkqsrseaml qatcgtpiym apevisahdy
      301 sqqcdiwsig vvmymllrge ppflasseek lfelirkgel hfenavwnsi sdcaksvlkq
      361 lmkvdpahri takelldnqw ltgnklssvr ptnvlemmke wknnpesvee ntteeknkps
      421 teeklksyqp wgnvpdanyt sdeeeekqst ayekqfpats kdnfdmcsss ftsskllpae
      481 ikgemektpv tpsqgtatky paksgalsrt kkkl
//
LOCUS       XP_054225668             514 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase 33 isoform X1 [Homo sapiens].
ACCESSION   XP_054225668
VERSION     XP_054225668.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369693.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..514
                     /product="serine/threonine-protein kinase 33 isoform X1"
                     /calculated_mol_wt=57700
     Region          114..381
                     /region_name="STKc_STK33"
                     /note="Catalytic domain of Serine/Threonine Kinase 33;
                     cd14097"
                     /db_xref="CDD:270999"
     Site            order(122..126,130,143,145,176,192..195,199,201,237..238,
                     240,242..243,245,264..265,268,284..288,290)
                     /site_type="active"
                     /db_xref="CDD:270999"
     Site            order(122..125,130,143,145,176,192..195,199,242..243,245,
                     264..265)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270999"
     Site            order(126,199,201,237..238,240,242,268,284..288,290)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270999"
     Site            order(264..278,280..288)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270999"
     CDS             1..514
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /coded_by="XM_054369693.1:561..2105"
                     /db_xref="GeneID:65975"
                     /db_xref="HGNC:HGNC:14568"
                     /db_xref="MIM:607670"
ORIGIN      
        1 madsgldkks tkcpdcssas qkdvlcvcss ktrvppvlvv emsqtssigs aeslislerk
       61 kekninrdit srkdlpsrts nverkasqqq wgrgnftegk vphirienga aieeiytfgr
      121 ilgkgsfgiv ieatdketet kwaikkvnke kagssavkll erevnilksv khehiihleq
      181 vfetpkkmyl vmelcedgel keildrkghf senetrwiiq slasaiaylh nndivhrdlk
      241 lenimvkssl iddnneinln ikvtdfglav kkqsrseaml qatcgtpiym apevisahdy
      301 sqqcdiwsig vvmymllrge ppflasseek lfelirkgel hfenavwnsi sdcaksvlkq
      361 lmkvdpahri takelldnqw ltgnklssvr ptnvlemmke wknnpesvee ntteeknkps
      421 teeklksyqp wgnvpdanyt sdeeeekqst ayekqfpats kdnfdmcsss ftsskllpae
      481 ikgemektpv tpsqgtatky paksgalsrt kkkl
//
LOCUS       XP_054225669             514 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase 33 isoform X1 [Homo sapiens].
ACCESSION   XP_054225669
VERSION     XP_054225669.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369694.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..514
                     /product="serine/threonine-protein kinase 33 isoform X1"
                     /calculated_mol_wt=57700
     Region          114..381
                     /region_name="STKc_STK33"
                     /note="Catalytic domain of Serine/Threonine Kinase 33;
                     cd14097"
                     /db_xref="CDD:270999"
     Site            order(122..126,130,143,145,176,192..195,199,201,237..238,
                     240,242..243,245,264..265,268,284..288,290)
                     /site_type="active"
                     /db_xref="CDD:270999"
     Site            order(122..125,130,143,145,176,192..195,199,242..243,245,
                     264..265)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270999"
     Site            order(126,199,201,237..238,240,242,268,284..288,290)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270999"
     Site            order(264..278,280..288)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270999"
     CDS             1..514
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /coded_by="XM_054369694.1:497..2041"
                     /db_xref="GeneID:65975"
                     /db_xref="HGNC:HGNC:14568"
                     /db_xref="MIM:607670"
ORIGIN      
        1 madsgldkks tkcpdcssas qkdvlcvcss ktrvppvlvv emsqtssigs aeslislerk
       61 kekninrdit srkdlpsrts nverkasqqq wgrgnftegk vphirienga aieeiytfgr
      121 ilgkgsfgiv ieatdketet kwaikkvnke kagssavkll erevnilksv khehiihleq
      181 vfetpkkmyl vmelcedgel keildrkghf senetrwiiq slasaiaylh nndivhrdlk
      241 lenimvkssl iddnneinln ikvtdfglav kkqsrseaml qatcgtpiym apevisahdy
      301 sqqcdiwsig vvmymllrge ppflasseek lfelirkgel hfenavwnsi sdcaksvlkq
      361 lmkvdpahri takelldnqw ltgnklssvr ptnvlemmke wknnpesvee ntteeknkps
      421 teeklksyqp wgnvpdanyt sdeeeekqst ayekqfpats kdnfdmcsss ftsskllpae
      481 ikgemektpv tpsqgtatky paksgalsrt kkkl
//
LOCUS       XP_054225670             514 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase 33 isoform X1 [Homo sapiens].
ACCESSION   XP_054225670
VERSION     XP_054225670.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369695.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..514
                     /product="serine/threonine-protein kinase 33 isoform X1"
                     /calculated_mol_wt=57700
     Region          114..381
                     /region_name="STKc_STK33"
                     /note="Catalytic domain of Serine/Threonine Kinase 33;
                     cd14097"
                     /db_xref="CDD:270999"
     Site            order(122..126,130,143,145,176,192..195,199,201,237..238,
                     240,242..243,245,264..265,268,284..288,290)
                     /site_type="active"
                     /db_xref="CDD:270999"
     Site            order(122..125,130,143,145,176,192..195,199,242..243,245,
                     264..265)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270999"
     Site            order(126,199,201,237..238,240,242,268,284..288,290)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270999"
     Site            order(264..278,280..288)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270999"
     CDS             1..514
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /coded_by="XM_054369695.1:476..2020"
                     /db_xref="GeneID:65975"
                     /db_xref="HGNC:HGNC:14568"
                     /db_xref="MIM:607670"
ORIGIN      
        1 madsgldkks tkcpdcssas qkdvlcvcss ktrvppvlvv emsqtssigs aeslislerk
       61 kekninrdit srkdlpsrts nverkasqqq wgrgnftegk vphirienga aieeiytfgr
      121 ilgkgsfgiv ieatdketet kwaikkvnke kagssavkll erevnilksv khehiihleq
      181 vfetpkkmyl vmelcedgel keildrkghf senetrwiiq slasaiaylh nndivhrdlk
      241 lenimvkssl iddnneinln ikvtdfglav kkqsrseaml qatcgtpiym apevisahdy
      301 sqqcdiwsig vvmymllrge ppflasseek lfelirkgel hfenavwnsi sdcaksvlkq
      361 lmkvdpahri takelldnqw ltgnklssvr ptnvlemmke wknnpesvee ntteeknkps
      421 teeklksyqp wgnvpdanyt sdeeeekqst ayekqfpats kdnfdmcsss ftsskllpae
      481 ikgemektpv tpsqgtatky paksgalsrt kkkl
//
LOCUS       XP_054225671             514 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase 33 isoform X1 [Homo sapiens].
ACCESSION   XP_054225671
VERSION     XP_054225671.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369696.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..514
                     /product="serine/threonine-protein kinase 33 isoform X1"
                     /calculated_mol_wt=57700
     Region          114..381
                     /region_name="STKc_STK33"
                     /note="Catalytic domain of Serine/Threonine Kinase 33;
                     cd14097"
                     /db_xref="CDD:270999"
     Site            order(122..126,130,143,145,176,192..195,199,201,237..238,
                     240,242..243,245,264..265,268,284..288,290)
                     /site_type="active"
                     /db_xref="CDD:270999"
     Site            order(122..125,130,143,145,176,192..195,199,242..243,245,
                     264..265)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270999"
     Site            order(126,199,201,237..238,240,242,268,284..288,290)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270999"
     Site            order(264..278,280..288)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270999"
     CDS             1..514
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /coded_by="XM_054369696.1:389..1933"
                     /db_xref="GeneID:65975"
                     /db_xref="HGNC:HGNC:14568"
                     /db_xref="MIM:607670"
ORIGIN      
        1 madsgldkks tkcpdcssas qkdvlcvcss ktrvppvlvv emsqtssigs aeslislerk
       61 kekninrdit srkdlpsrts nverkasqqq wgrgnftegk vphirienga aieeiytfgr
      121 ilgkgsfgiv ieatdketet kwaikkvnke kagssavkll erevnilksv khehiihleq
      181 vfetpkkmyl vmelcedgel keildrkghf senetrwiiq slasaiaylh nndivhrdlk
      241 lenimvkssl iddnneinln ikvtdfglav kkqsrseaml qatcgtpiym apevisahdy
      301 sqqcdiwsig vvmymllrge ppflasseek lfelirkgel hfenavwnsi sdcaksvlkq
      361 lmkvdpahri takelldnqw ltgnklssvr ptnvlemmke wknnpesvee ntteeknkps
      421 teeklksyqp wgnvpdanyt sdeeeekqst ayekqfpats kdnfdmcsss ftsskllpae
      481 ikgemektpv tpsqgtatky paksgalsrt kkkl
//
LOCUS       XP_054225672             514 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase 33 isoform X1 [Homo sapiens].
ACCESSION   XP_054225672
VERSION     XP_054225672.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369697.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..514
                     /product="serine/threonine-protein kinase 33 isoform X1"
                     /calculated_mol_wt=57700
     Region          114..381
                     /region_name="STKc_STK33"
                     /note="Catalytic domain of Serine/Threonine Kinase 33;
                     cd14097"
                     /db_xref="CDD:270999"
     Site            order(122..126,130,143,145,176,192..195,199,201,237..238,
                     240,242..243,245,264..265,268,284..288,290)
                     /site_type="active"
                     /db_xref="CDD:270999"
     Site            order(122..125,130,143,145,176,192..195,199,242..243,245,
                     264..265)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270999"
     Site            order(126,199,201,237..238,240,242,268,284..288,290)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270999"
     Site            order(264..278,280..288)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270999"
     CDS             1..514
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /coded_by="XM_054369697.1:539..2083"
                     /db_xref="GeneID:65975"
                     /db_xref="HGNC:HGNC:14568"
                     /db_xref="MIM:607670"
ORIGIN      
        1 madsgldkks tkcpdcssas qkdvlcvcss ktrvppvlvv emsqtssigs aeslislerk
       61 kekninrdit srkdlpsrts nverkasqqq wgrgnftegk vphirienga aieeiytfgr
      121 ilgkgsfgiv ieatdketet kwaikkvnke kagssavkll erevnilksv khehiihleq
      181 vfetpkkmyl vmelcedgel keildrkghf senetrwiiq slasaiaylh nndivhrdlk
      241 lenimvkssl iddnneinln ikvtdfglav kkqsrseaml qatcgtpiym apevisahdy
      301 sqqcdiwsig vvmymllrge ppflasseek lfelirkgel hfenavwnsi sdcaksvlkq
      361 lmkvdpahri takelldnqw ltgnklssvr ptnvlemmke wknnpesvee ntteeknkps
      421 teeklksyqp wgnvpdanyt sdeeeekqst ayekqfpats kdnfdmcsss ftsskllpae
      481 ikgemektpv tpsqgtatky paksgalsrt kkkl
//
LOCUS       XP_054225673             514 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase 33 isoform X1 [Homo sapiens].
ACCESSION   XP_054225673
VERSION     XP_054225673.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369698.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..514
                     /product="serine/threonine-protein kinase 33 isoform X1"
                     /calculated_mol_wt=57700
     Region          114..381
                     /region_name="STKc_STK33"
                     /note="Catalytic domain of Serine/Threonine Kinase 33;
                     cd14097"
                     /db_xref="CDD:270999"
     Site            order(122..126,130,143,145,176,192..195,199,201,237..238,
                     240,242..243,245,264..265,268,284..288,290)
                     /site_type="active"
                     /db_xref="CDD:270999"
     Site            order(122..125,130,143,145,176,192..195,199,242..243,245,
                     264..265)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270999"
     Site            order(126,199,201,237..238,240,242,268,284..288,290)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270999"
     Site            order(264..278,280..288)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270999"
     CDS             1..514
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /coded_by="XM_054369698.1:410..1954"
                     /db_xref="GeneID:65975"
                     /db_xref="HGNC:HGNC:14568"
                     /db_xref="MIM:607670"
ORIGIN      
        1 madsgldkks tkcpdcssas qkdvlcvcss ktrvppvlvv emsqtssigs aeslislerk
       61 kekninrdit srkdlpsrts nverkasqqq wgrgnftegk vphirienga aieeiytfgr
      121 ilgkgsfgiv ieatdketet kwaikkvnke kagssavkll erevnilksv khehiihleq
      181 vfetpkkmyl vmelcedgel keildrkghf senetrwiiq slasaiaylh nndivhrdlk
      241 lenimvkssl iddnneinln ikvtdfglav kkqsrseaml qatcgtpiym apevisahdy
      301 sqqcdiwsig vvmymllrge ppflasseek lfelirkgel hfenavwnsi sdcaksvlkq
      361 lmkvdpahri takelldnqw ltgnklssvr ptnvlemmke wknnpesvee ntteeknkps
      421 teeklksyqp wgnvpdanyt sdeeeekqst ayekqfpats kdnfdmcsss ftsskllpae
      481 ikgemektpv tpsqgtatky paksgalsrt kkkl
//
LOCUS       XP_054225674             514 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase 33 isoform X1 [Homo sapiens].
ACCESSION   XP_054225674
VERSION     XP_054225674.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369699.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..514
                     /product="serine/threonine-protein kinase 33 isoform X1"
                     /calculated_mol_wt=57700
     Region          114..381
                     /region_name="STKc_STK33"
                     /note="Catalytic domain of Serine/Threonine Kinase 33;
                     cd14097"
                     /db_xref="CDD:270999"
     Site            order(122..126,130,143,145,176,192..195,199,201,237..238,
                     240,242..243,245,264..265,268,284..288,290)
                     /site_type="active"
                     /db_xref="CDD:270999"
     Site            order(122..125,130,143,145,176,192..195,199,242..243,245,
                     264..265)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270999"
     Site            order(126,199,201,237..238,240,242,268,284..288,290)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270999"
     Site            order(264..278,280..288)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270999"
     CDS             1..514
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /coded_by="XM_054369699.1:575..2119"
                     /db_xref="GeneID:65975"
                     /db_xref="HGNC:HGNC:14568"
                     /db_xref="MIM:607670"
ORIGIN      
        1 madsgldkks tkcpdcssas qkdvlcvcss ktrvppvlvv emsqtssigs aeslislerk
       61 kekninrdit srkdlpsrts nverkasqqq wgrgnftegk vphirienga aieeiytfgr
      121 ilgkgsfgiv ieatdketet kwaikkvnke kagssavkll erevnilksv khehiihleq
      181 vfetpkkmyl vmelcedgel keildrkghf senetrwiiq slasaiaylh nndivhrdlk
      241 lenimvkssl iddnneinln ikvtdfglav kkqsrseaml qatcgtpiym apevisahdy
      301 sqqcdiwsig vvmymllrge ppflasseek lfelirkgel hfenavwnsi sdcaksvlkq
      361 lmkvdpahri takelldnqw ltgnklssvr ptnvlemmke wknnpesvee ntteeknkps
      421 teeklksyqp wgnvpdanyt sdeeeekqst ayekqfpats kdnfdmcsss ftsskllpae
      481 ikgemektpv tpsqgtatky paksgalsrt kkkl
//
LOCUS       XP_054225675             514 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase 33 isoform X1 [Homo sapiens].
ACCESSION   XP_054225675
VERSION     XP_054225675.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369700.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..514
                     /product="serine/threonine-protein kinase 33 isoform X1"
                     /calculated_mol_wt=57700
     Region          114..381
                     /region_name="STKc_STK33"
                     /note="Catalytic domain of Serine/Threonine Kinase 33;
                     cd14097"
                     /db_xref="CDD:270999"
     Site            order(122..126,130,143,145,176,192..195,199,201,237..238,
                     240,242..243,245,264..265,268,284..288,290)
                     /site_type="active"
                     /db_xref="CDD:270999"
     Site            order(122..125,130,143,145,176,192..195,199,242..243,245,
                     264..265)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270999"
     Site            order(126,199,201,237..238,240,242,268,284..288,290)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270999"
     Site            order(264..278,280..288)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270999"
     CDS             1..514
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /coded_by="XM_054369700.1:542..2086"
                     /db_xref="GeneID:65975"
                     /db_xref="HGNC:HGNC:14568"
                     /db_xref="MIM:607670"
ORIGIN      
        1 madsgldkks tkcpdcssas qkdvlcvcss ktrvppvlvv emsqtssigs aeslislerk
       61 kekninrdit srkdlpsrts nverkasqqq wgrgnftegk vphirienga aieeiytfgr
      121 ilgkgsfgiv ieatdketet kwaikkvnke kagssavkll erevnilksv khehiihleq
      181 vfetpkkmyl vmelcedgel keildrkghf senetrwiiq slasaiaylh nndivhrdlk
      241 lenimvkssl iddnneinln ikvtdfglav kkqsrseaml qatcgtpiym apevisahdy
      301 sqqcdiwsig vvmymllrge ppflasseek lfelirkgel hfenavwnsi sdcaksvlkq
      361 lmkvdpahri takelldnqw ltgnklssvr ptnvlemmke wknnpesvee ntteeknkps
      421 teeklksyqp wgnvpdanyt sdeeeekqst ayekqfpats kdnfdmcsss ftsskllpae
      481 ikgemektpv tpsqgtatky paksgalsrt kkkl
//
LOCUS       XP_054225676             514 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase 33 isoform X1 [Homo sapiens].
ACCESSION   XP_054225676
VERSION     XP_054225676.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369701.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..514
                     /product="serine/threonine-protein kinase 33 isoform X1"
                     /calculated_mol_wt=57700
     Region          114..381
                     /region_name="STKc_STK33"
                     /note="Catalytic domain of Serine/Threonine Kinase 33;
                     cd14097"
                     /db_xref="CDD:270999"
     Site            order(122..126,130,143,145,176,192..195,199,201,237..238,
                     240,242..243,245,264..265,268,284..288,290)
                     /site_type="active"
                     /db_xref="CDD:270999"
     Site            order(122..125,130,143,145,176,192..195,199,242..243,245,
                     264..265)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270999"
     Site            order(126,199,201,237..238,240,242,268,284..288,290)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270999"
     Site            order(264..278,280..288)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270999"
     CDS             1..514
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /coded_by="XM_054369701.1:3326..4870"
                     /db_xref="GeneID:65975"
                     /db_xref="HGNC:HGNC:14568"
                     /db_xref="MIM:607670"
ORIGIN      
        1 madsgldkks tkcpdcssas qkdvlcvcss ktrvppvlvv emsqtssigs aeslislerk
       61 kekninrdit srkdlpsrts nverkasqqq wgrgnftegk vphirienga aieeiytfgr
      121 ilgkgsfgiv ieatdketet kwaikkvnke kagssavkll erevnilksv khehiihleq
      181 vfetpkkmyl vmelcedgel keildrkghf senetrwiiq slasaiaylh nndivhrdlk
      241 lenimvkssl iddnneinln ikvtdfglav kkqsrseaml qatcgtpiym apevisahdy
      301 sqqcdiwsig vvmymllrge ppflasseek lfelirkgel hfenavwnsi sdcaksvlkq
      361 lmkvdpahri takelldnqw ltgnklssvr ptnvlemmke wknnpesvee ntteeknkps
      421 teeklksyqp wgnvpdanyt sdeeeekqst ayekqfpats kdnfdmcsss ftsskllpae
      481 ikgemektpv tpsqgtatky paksgalsrt kkkl
//
LOCUS       XP_054225677             514 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase 33 isoform X1 [Homo sapiens].
ACCESSION   XP_054225677
VERSION     XP_054225677.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369702.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..514
                     /product="serine/threonine-protein kinase 33 isoform X1"
                     /calculated_mol_wt=57700
     Region          114..381
                     /region_name="STKc_STK33"
                     /note="Catalytic domain of Serine/Threonine Kinase 33;
                     cd14097"
                     /db_xref="CDD:270999"
     Site            order(122..126,130,143,145,176,192..195,199,201,237..238,
                     240,242..243,245,264..265,268,284..288,290)
                     /site_type="active"
                     /db_xref="CDD:270999"
     Site            order(122..125,130,143,145,176,192..195,199,242..243,245,
                     264..265)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270999"
     Site            order(126,199,201,237..238,240,242,268,284..288,290)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270999"
     Site            order(264..278,280..288)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270999"
     CDS             1..514
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /coded_by="XM_054369702.1:429..1973"
                     /db_xref="GeneID:65975"
                     /db_xref="HGNC:HGNC:14568"
                     /db_xref="MIM:607670"
ORIGIN      
        1 madsgldkks tkcpdcssas qkdvlcvcss ktrvppvlvv emsqtssigs aeslislerk
       61 kekninrdit srkdlpsrts nverkasqqq wgrgnftegk vphirienga aieeiytfgr
      121 ilgkgsfgiv ieatdketet kwaikkvnke kagssavkll erevnilksv khehiihleq
      181 vfetpkkmyl vmelcedgel keildrkghf senetrwiiq slasaiaylh nndivhrdlk
      241 lenimvkssl iddnneinln ikvtdfglav kkqsrseaml qatcgtpiym apevisahdy
      301 sqqcdiwsig vvmymllrge ppflasseek lfelirkgel hfenavwnsi sdcaksvlkq
      361 lmkvdpahri takelldnqw ltgnklssvr ptnvlemmke wknnpesvee ntteeknkps
      421 teeklksyqp wgnvpdanyt sdeeeekqst ayekqfpats kdnfdmcsss ftsskllpae
      481 ikgemektpv tpsqgtatky paksgalsrt kkkl
//
LOCUS       XP_054225678             514 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase 33 isoform X1 [Homo sapiens].
ACCESSION   XP_054225678
VERSION     XP_054225678.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369703.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..514
                     /product="serine/threonine-protein kinase 33 isoform X1"
                     /calculated_mol_wt=57700
     Region          114..381
                     /region_name="STKc_STK33"
                     /note="Catalytic domain of Serine/Threonine Kinase 33;
                     cd14097"
                     /db_xref="CDD:270999"
     Site            order(122..126,130,143,145,176,192..195,199,201,237..238,
                     240,242..243,245,264..265,268,284..288,290)
                     /site_type="active"
                     /db_xref="CDD:270999"
     Site            order(122..125,130,143,145,176,192..195,199,242..243,245,
                     264..265)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270999"
     Site            order(126,199,201,237..238,240,242,268,284..288,290)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270999"
     Site            order(264..278,280..288)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270999"
     CDS             1..514
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /coded_by="XM_054369703.1:723..2267"
                     /db_xref="GeneID:65975"
                     /db_xref="HGNC:HGNC:14568"
                     /db_xref="MIM:607670"
ORIGIN      
        1 madsgldkks tkcpdcssas qkdvlcvcss ktrvppvlvv emsqtssigs aeslislerk
       61 kekninrdit srkdlpsrts nverkasqqq wgrgnftegk vphirienga aieeiytfgr
      121 ilgkgsfgiv ieatdketet kwaikkvnke kagssavkll erevnilksv khehiihleq
      181 vfetpkkmyl vmelcedgel keildrkghf senetrwiiq slasaiaylh nndivhrdlk
      241 lenimvkssl iddnneinln ikvtdfglav kkqsrseaml qatcgtpiym apevisahdy
      301 sqqcdiwsig vvmymllrge ppflasseek lfelirkgel hfenavwnsi sdcaksvlkq
      361 lmkvdpahri takelldnqw ltgnklssvr ptnvlemmke wknnpesvee ntteeknkps
      421 teeklksyqp wgnvpdanyt sdeeeekqst ayekqfpats kdnfdmcsss ftsskllpae
      481 ikgemektpv tpsqgtatky paksgalsrt kkkl
//
LOCUS       XP_054225679             514 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase 33 isoform X1 [Homo sapiens].
ACCESSION   XP_054225679
VERSION     XP_054225679.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369704.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..514
                     /product="serine/threonine-protein kinase 33 isoform X1"
                     /calculated_mol_wt=57700
     Region          114..381
                     /region_name="STKc_STK33"
                     /note="Catalytic domain of Serine/Threonine Kinase 33;
                     cd14097"
                     /db_xref="CDD:270999"
     Site            order(122..126,130,143,145,176,192..195,199,201,237..238,
                     240,242..243,245,264..265,268,284..288,290)
                     /site_type="active"
                     /db_xref="CDD:270999"
     Site            order(122..125,130,143,145,176,192..195,199,242..243,245,
                     264..265)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270999"
     Site            order(126,199,201,237..238,240,242,268,284..288,290)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270999"
     Site            order(264..278,280..288)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270999"
     CDS             1..514
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /coded_by="XM_054369704.1:735..2279"
                     /db_xref="GeneID:65975"
                     /db_xref="HGNC:HGNC:14568"
                     /db_xref="MIM:607670"
ORIGIN      
        1 madsgldkks tkcpdcssas qkdvlcvcss ktrvppvlvv emsqtssigs aeslislerk
       61 kekninrdit srkdlpsrts nverkasqqq wgrgnftegk vphirienga aieeiytfgr
      121 ilgkgsfgiv ieatdketet kwaikkvnke kagssavkll erevnilksv khehiihleq
      181 vfetpkkmyl vmelcedgel keildrkghf senetrwiiq slasaiaylh nndivhrdlk
      241 lenimvkssl iddnneinln ikvtdfglav kkqsrseaml qatcgtpiym apevisahdy
      301 sqqcdiwsig vvmymllrge ppflasseek lfelirkgel hfenavwnsi sdcaksvlkq
      361 lmkvdpahri takelldnqw ltgnklssvr ptnvlemmke wknnpesvee ntteeknkps
      421 teeklksyqp wgnvpdanyt sdeeeekqst ayekqfpats kdnfdmcsss ftsskllpae
      481 ikgemektpv tpsqgtatky paksgalsrt kkkl
//
LOCUS       XP_054225680             514 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase 33 isoform X1 [Homo sapiens].
ACCESSION   XP_054225680
VERSION     XP_054225680.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369705.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..514
                     /product="serine/threonine-protein kinase 33 isoform X1"
                     /calculated_mol_wt=57700
     Region          114..381
                     /region_name="STKc_STK33"
                     /note="Catalytic domain of Serine/Threonine Kinase 33;
                     cd14097"
                     /db_xref="CDD:270999"
     Site            order(122..126,130,143,145,176,192..195,199,201,237..238,
                     240,242..243,245,264..265,268,284..288,290)
                     /site_type="active"
                     /db_xref="CDD:270999"
     Site            order(122..125,130,143,145,176,192..195,199,242..243,245,
                     264..265)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270999"
     Site            order(126,199,201,237..238,240,242,268,284..288,290)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270999"
     Site            order(264..278,280..288)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270999"
     CDS             1..514
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /coded_by="XM_054369705.1:179..1723"
                     /db_xref="GeneID:65975"
                     /db_xref="HGNC:HGNC:14568"
                     /db_xref="MIM:607670"
ORIGIN      
        1 madsgldkks tkcpdcssas qkdvlcvcss ktrvppvlvv emsqtssigs aeslislerk
       61 kekninrdit srkdlpsrts nverkasqqq wgrgnftegk vphirienga aieeiytfgr
      121 ilgkgsfgiv ieatdketet kwaikkvnke kagssavkll erevnilksv khehiihleq
      181 vfetpkkmyl vmelcedgel keildrkghf senetrwiiq slasaiaylh nndivhrdlk
      241 lenimvkssl iddnneinln ikvtdfglav kkqsrseaml qatcgtpiym apevisahdy
      301 sqqcdiwsig vvmymllrge ppflasseek lfelirkgel hfenavwnsi sdcaksvlkq
      361 lmkvdpahri takelldnqw ltgnklssvr ptnvlemmke wknnpesvee ntteeknkps
      421 teeklksyqp wgnvpdanyt sdeeeekqst ayekqfpats kdnfdmcsss ftsskllpae
      481 ikgemektpv tpsqgtatky paksgalsrt kkkl
//
LOCUS       XP_054225681             473 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase 33 isoform X2 [Homo sapiens].
ACCESSION   XP_054225681
VERSION     XP_054225681.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369706.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..473
                     /product="serine/threonine-protein kinase 33 isoform X2"
                     /calculated_mol_wt=53405
     Region          73..340
                     /region_name="STKc_STK33"
                     /note="Catalytic domain of Serine/Threonine Kinase 33;
                     cd14097"
                     /db_xref="CDD:270999"
     Site            order(81..85,89,102,104,135,151..154,158,160,196..197,199,
                     201..202,204,223..224,227,243..247,249)
                     /site_type="active"
                     /db_xref="CDD:270999"
     Site            order(81..84,89,102,104,135,151..154,158,201..202,204,
                     223..224)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270999"
     Site            order(85,158,160,196..197,199,201,227,243..247,249)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270999"
     Site            order(223..237,239..247)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270999"
     CDS             1..473
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /coded_by="XM_054369706.1:181..1602"
                     /db_xref="GeneID:65975"
                     /db_xref="HGNC:HGNC:14568"
                     /db_xref="MIM:607670"
ORIGIN      
        1 msqtssigsa eslislerkk ekninrdits rkdlpsrtsn verkasqqqw grgnftegkv
       61 phiriengaa ieeiytfgri lgkgsfgivi eatdketetk waikkvnkek agssavklle
      121 revnilksvk hehiihleqv fetpkkmylv melcedgelk eildrkghfs enetrwiiqs
      181 lasaiaylhn ndivhrdlkl enimvkssli ddnneinlni kvtdfglavk kqsrseamlq
      241 atcgtpiyma pevisahdys qqcdiwsigv vmymllrgep pflasseekl felirkgelh
      301 fenavwnsis dcaksvlkql mkvdpahrit akelldnqwl tgnklssvrp tnvlemmkew
      361 knnpesveen tteeknkpst eeklksyqpw gnvpdanyts deeeekqsta yekqfpatsk
      421 dnfdmcsssf tsskllpaei kgemektpvt psqgtatkyp aksgalsrtk kkl
//
LOCUS       XP_054225682             473 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase 33 isoform X2 [Homo sapiens].
ACCESSION   XP_054225682
VERSION     XP_054225682.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369707.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..473
                     /product="serine/threonine-protein kinase 33 isoform X2"
                     /calculated_mol_wt=53405
     Region          73..340
                     /region_name="STKc_STK33"
                     /note="Catalytic domain of Serine/Threonine Kinase 33;
                     cd14097"
                     /db_xref="CDD:270999"
     Site            order(81..85,89,102,104,135,151..154,158,160,196..197,199,
                     201..202,204,223..224,227,243..247,249)
                     /site_type="active"
                     /db_xref="CDD:270999"
     Site            order(81..84,89,102,104,135,151..154,158,201..202,204,
                     223..224)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270999"
     Site            order(85,158,160,196..197,199,201,227,243..247,249)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270999"
     Site            order(223..237,239..247)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270999"
     CDS             1..473
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /coded_by="XM_054369707.1:420..1841"
                     /db_xref="GeneID:65975"
                     /db_xref="HGNC:HGNC:14568"
                     /db_xref="MIM:607670"
ORIGIN      
        1 msqtssigsa eslislerkk ekninrdits rkdlpsrtsn verkasqqqw grgnftegkv
       61 phiriengaa ieeiytfgri lgkgsfgivi eatdketetk waikkvnkek agssavklle
      121 revnilksvk hehiihleqv fetpkkmylv melcedgelk eildrkghfs enetrwiiqs
      181 lasaiaylhn ndivhrdlkl enimvkssli ddnneinlni kvtdfglavk kqsrseamlq
      241 atcgtpiyma pevisahdys qqcdiwsigv vmymllrgep pflasseekl felirkgelh
      301 fenavwnsis dcaksvlkql mkvdpahrit akelldnqwl tgnklssvrp tnvlemmkew
      361 knnpesveen tteeknkpst eeklksyqpw gnvpdanyts deeeekqsta yekqfpatsk
      421 dnfdmcsssf tsskllpaei kgemektpvt psqgtatkyp aksgalsrtk kkl
//
LOCUS       XP_054225683             473 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase 33 isoform X2 [Homo sapiens].
ACCESSION   XP_054225683
VERSION     XP_054225683.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369708.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..473
                     /product="serine/threonine-protein kinase 33 isoform X2"
                     /calculated_mol_wt=53405
     Region          73..340
                     /region_name="STKc_STK33"
                     /note="Catalytic domain of Serine/Threonine Kinase 33;
                     cd14097"
                     /db_xref="CDD:270999"
     Site            order(81..85,89,102,104,135,151..154,158,160,196..197,199,
                     201..202,204,223..224,227,243..247,249)
                     /site_type="active"
                     /db_xref="CDD:270999"
     Site            order(81..84,89,102,104,135,151..154,158,201..202,204,
                     223..224)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270999"
     Site            order(85,158,160,196..197,199,201,227,243..247,249)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270999"
     Site            order(223..237,239..247)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270999"
     CDS             1..473
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /coded_by="XM_054369708.1:215..1636"
                     /db_xref="GeneID:65975"
                     /db_xref="HGNC:HGNC:14568"
                     /db_xref="MIM:607670"
ORIGIN      
        1 msqtssigsa eslislerkk ekninrdits rkdlpsrtsn verkasqqqw grgnftegkv
       61 phiriengaa ieeiytfgri lgkgsfgivi eatdketetk waikkvnkek agssavklle
      121 revnilksvk hehiihleqv fetpkkmylv melcedgelk eildrkghfs enetrwiiqs
      181 lasaiaylhn ndivhrdlkl enimvkssli ddnneinlni kvtdfglavk kqsrseamlq
      241 atcgtpiyma pevisahdys qqcdiwsigv vmymllrgep pflasseekl felirkgelh
      301 fenavwnsis dcaksvlkql mkvdpahrit akelldnqwl tgnklssvrp tnvlemmkew
      361 knnpesveen tteeknkpst eeklksyqpw gnvpdanyts deeeekqsta yekqfpatsk
      421 dnfdmcsssf tsskllpaei kgemektpvt psqgtatkyp aksgalsrtk kkl
//
LOCUS       XP_054225684             473 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase 33 isoform X2 [Homo sapiens].
ACCESSION   XP_054225684
VERSION     XP_054225684.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369709.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..473
                     /product="serine/threonine-protein kinase 33 isoform X2"
                     /calculated_mol_wt=53405
     Region          73..340
                     /region_name="STKc_STK33"
                     /note="Catalytic domain of Serine/Threonine Kinase 33;
                     cd14097"
                     /db_xref="CDD:270999"
     Site            order(81..85,89,102,104,135,151..154,158,160,196..197,199,
                     201..202,204,223..224,227,243..247,249)
                     /site_type="active"
                     /db_xref="CDD:270999"
     Site            order(81..84,89,102,104,135,151..154,158,201..202,204,
                     223..224)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270999"
     Site            order(85,158,160,196..197,199,201,227,243..247,249)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270999"
     Site            order(223..237,239..247)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270999"
     CDS             1..473
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /coded_by="XM_054369709.1:296..1717"
                     /db_xref="GeneID:65975"
                     /db_xref="HGNC:HGNC:14568"
                     /db_xref="MIM:607670"
ORIGIN      
        1 msqtssigsa eslislerkk ekninrdits rkdlpsrtsn verkasqqqw grgnftegkv
       61 phiriengaa ieeiytfgri lgkgsfgivi eatdketetk waikkvnkek agssavklle
      121 revnilksvk hehiihleqv fetpkkmylv melcedgelk eildrkghfs enetrwiiqs
      181 lasaiaylhn ndivhrdlkl enimvkssli ddnneinlni kvtdfglavk kqsrseamlq
      241 atcgtpiyma pevisahdys qqcdiwsigv vmymllrgep pflasseekl felirkgelh
      301 fenavwnsis dcaksvlkql mkvdpahrit akelldnqwl tgnklssvrp tnvlemmkew
      361 knnpesveen tteeknkpst eeklksyqpw gnvpdanyts deeeekqsta yekqfpatsk
      421 dnfdmcsssf tsskllpaei kgemektpvt psqgtatkyp aksgalsrtk kkl
//
LOCUS       XP_054225685             473 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase 33 isoform X2 [Homo sapiens].
ACCESSION   XP_054225685
VERSION     XP_054225685.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369710.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..473
                     /product="serine/threonine-protein kinase 33 isoform X2"
                     /calculated_mol_wt=53405
     Region          73..340
                     /region_name="STKc_STK33"
                     /note="Catalytic domain of Serine/Threonine Kinase 33;
                     cd14097"
                     /db_xref="CDD:270999"
     Site            order(81..85,89,102,104,135,151..154,158,160,196..197,199,
                     201..202,204,223..224,227,243..247,249)
                     /site_type="active"
                     /db_xref="CDD:270999"
     Site            order(81..84,89,102,104,135,151..154,158,201..202,204,
                     223..224)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270999"
     Site            order(85,158,160,196..197,199,201,227,243..247,249)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270999"
     Site            order(223..237,239..247)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270999"
     CDS             1..473
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /coded_by="XM_054369710.1:302..1723"
                     /db_xref="GeneID:65975"
                     /db_xref="HGNC:HGNC:14568"
                     /db_xref="MIM:607670"
ORIGIN      
        1 msqtssigsa eslislerkk ekninrdits rkdlpsrtsn verkasqqqw grgnftegkv
       61 phiriengaa ieeiytfgri lgkgsfgivi eatdketetk waikkvnkek agssavklle
      121 revnilksvk hehiihleqv fetpkkmylv melcedgelk eildrkghfs enetrwiiqs
      181 lasaiaylhn ndivhrdlkl enimvkssli ddnneinlni kvtdfglavk kqsrseamlq
      241 atcgtpiyma pevisahdys qqcdiwsigv vmymllrgep pflasseekl felirkgelh
      301 fenavwnsis dcaksvlkql mkvdpahrit akelldnqwl tgnklssvrp tnvlemmkew
      361 knnpesveen tteeknkpst eeklksyqpw gnvpdanyts deeeekqsta yekqfpatsk
      421 dnfdmcsssf tsskllpaei kgemektpvt psqgtatkyp aksgalsrtk kkl
//
LOCUS       XP_054225686             473 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase 33 isoform X2 [Homo sapiens].
ACCESSION   XP_054225686
VERSION     XP_054225686.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369711.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..473
                     /product="serine/threonine-protein kinase 33 isoform X2"
                     /calculated_mol_wt=53405
     Region          73..340
                     /region_name="STKc_STK33"
                     /note="Catalytic domain of Serine/Threonine Kinase 33;
                     cd14097"
                     /db_xref="CDD:270999"
     Site            order(81..85,89,102,104,135,151..154,158,160,196..197,199,
                     201..202,204,223..224,227,243..247,249)
                     /site_type="active"
                     /db_xref="CDD:270999"
     Site            order(81..84,89,102,104,135,151..154,158,201..202,204,
                     223..224)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270999"
     Site            order(85,158,160,196..197,199,201,227,243..247,249)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270999"
     Site            order(223..237,239..247)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270999"
     CDS             1..473
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /coded_by="XM_054369711.1:268..1689"
                     /db_xref="GeneID:65975"
                     /db_xref="HGNC:HGNC:14568"
                     /db_xref="MIM:607670"
ORIGIN      
        1 msqtssigsa eslislerkk ekninrdits rkdlpsrtsn verkasqqqw grgnftegkv
       61 phiriengaa ieeiytfgri lgkgsfgivi eatdketetk waikkvnkek agssavklle
      121 revnilksvk hehiihleqv fetpkkmylv melcedgelk eildrkghfs enetrwiiqs
      181 lasaiaylhn ndivhrdlkl enimvkssli ddnneinlni kvtdfglavk kqsrseamlq
      241 atcgtpiyma pevisahdys qqcdiwsigv vmymllrgep pflasseekl felirkgelh
      301 fenavwnsis dcaksvlkql mkvdpahrit akelldnqwl tgnklssvrp tnvlemmkew
      361 knnpesveen tteeknkpst eeklksyqpw gnvpdanyts deeeekqsta yekqfpatsk
      421 dnfdmcsssf tsskllpaei kgemektpvt psqgtatkyp aksgalsrtk kkl
//
LOCUS       XP_054225687             473 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase 33 isoform X2 [Homo sapiens].
ACCESSION   XP_054225687
VERSION     XP_054225687.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369712.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..473
                     /product="serine/threonine-protein kinase 33 isoform X2"
                     /calculated_mol_wt=53405
     Region          73..340
                     /region_name="STKc_STK33"
                     /note="Catalytic domain of Serine/Threonine Kinase 33;
                     cd14097"
                     /db_xref="CDD:270999"
     Site            order(81..85,89,102,104,135,151..154,158,160,196..197,199,
                     201..202,204,223..224,227,243..247,249)
                     /site_type="active"
                     /db_xref="CDD:270999"
     Site            order(81..84,89,102,104,135,151..154,158,201..202,204,
                     223..224)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270999"
     Site            order(85,158,160,196..197,199,201,227,243..247,249)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270999"
     Site            order(223..237,239..247)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270999"
     CDS             1..473
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /coded_by="XM_054369712.1:347..1768"
                     /db_xref="GeneID:65975"
                     /db_xref="HGNC:HGNC:14568"
                     /db_xref="MIM:607670"
ORIGIN      
        1 msqtssigsa eslislerkk ekninrdits rkdlpsrtsn verkasqqqw grgnftegkv
       61 phiriengaa ieeiytfgri lgkgsfgivi eatdketetk waikkvnkek agssavklle
      121 revnilksvk hehiihleqv fetpkkmylv melcedgelk eildrkghfs enetrwiiqs
      181 lasaiaylhn ndivhrdlkl enimvkssli ddnneinlni kvtdfglavk kqsrseamlq
      241 atcgtpiyma pevisahdys qqcdiwsigv vmymllrgep pflasseekl felirkgelh
      301 fenavwnsis dcaksvlkql mkvdpahrit akelldnqwl tgnklssvrp tnvlemmkew
      361 knnpesveen tteeknkpst eeklksyqpw gnvpdanyts deeeekqsta yekqfpatsk
      421 dnfdmcsssf tsskllpaei kgemektpvt psqgtatkyp aksgalsrtk kkl
//
LOCUS       XP_054225688             473 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase 33 isoform X2 [Homo sapiens].
ACCESSION   XP_054225688
VERSION     XP_054225688.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369713.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..473
                     /product="serine/threonine-protein kinase 33 isoform X2"
                     /calculated_mol_wt=53405
     Region          73..340
                     /region_name="STKc_STK33"
                     /note="Catalytic domain of Serine/Threonine Kinase 33;
                     cd14097"
                     /db_xref="CDD:270999"
     Site            order(81..85,89,102,104,135,151..154,158,160,196..197,199,
                     201..202,204,223..224,227,243..247,249)
                     /site_type="active"
                     /db_xref="CDD:270999"
     Site            order(81..84,89,102,104,135,151..154,158,201..202,204,
                     223..224)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270999"
     Site            order(85,158,160,196..197,199,201,227,243..247,249)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270999"
     Site            order(223..237,239..247)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270999"
     CDS             1..473
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /coded_by="XM_054369713.1:313..1734"
                     /db_xref="GeneID:65975"
                     /db_xref="HGNC:HGNC:14568"
                     /db_xref="MIM:607670"
ORIGIN      
        1 msqtssigsa eslislerkk ekninrdits rkdlpsrtsn verkasqqqw grgnftegkv
       61 phiriengaa ieeiytfgri lgkgsfgivi eatdketetk waikkvnkek agssavklle
      121 revnilksvk hehiihleqv fetpkkmylv melcedgelk eildrkghfs enetrwiiqs
      181 lasaiaylhn ndivhrdlkl enimvkssli ddnneinlni kvtdfglavk kqsrseamlq
      241 atcgtpiyma pevisahdys qqcdiwsigv vmymllrgep pflasseekl felirkgelh
      301 fenavwnsis dcaksvlkql mkvdpahrit akelldnqwl tgnklssvrp tnvlemmkew
      361 knnpesveen tteeknkpst eeklksyqpw gnvpdanyts deeeekqsta yekqfpatsk
      421 dnfdmcsssf tsskllpaei kgemektpvt psqgtatkyp aksgalsrtk kkl
//
LOCUS       XP_054225689             458 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase 33 isoform X3 [Homo sapiens].
ACCESSION   XP_054225689
VERSION     XP_054225689.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369714.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..458
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..458
                     /product="serine/threonine-protein kinase 33 isoform X3"
                     /calculated_mol_wt=51638
     Region          114..381
                     /region_name="STKc_STK33"
                     /note="Catalytic domain of Serine/Threonine Kinase 33;
                     cd14097"
                     /db_xref="CDD:270999"
     Site            order(122..126,130,143,145,176,192..195,199,201,237..238,
                     240,242..243,245,264..265,268,284..288,290)
                     /site_type="active"
                     /db_xref="CDD:270999"
     Site            order(122..125,130,143,145,176,192..195,199,242..243,245,
                     264..265)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270999"
     Site            order(126,199,201,237..238,240,242,268,284..288,290)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270999"
     Site            order(264..278,280..288)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270999"
     CDS             1..458
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /coded_by="XM_054369714.1:11608..12984"
                     /db_xref="GeneID:65975"
                     /db_xref="HGNC:HGNC:14568"
                     /db_xref="MIM:607670"
ORIGIN      
        1 madsgldkks tkcpdcssas qkdvlcvcss ktrvppvlvv emsqtssigs aeslislerk
       61 kekninrdit srkdlpsrts nverkasqqq wgrgnftegk vphirienga aieeiytfgr
      121 ilgkgsfgiv ieatdketet kwaikkvnke kagssavkll erevnilksv khehiihleq
      181 vfetpkkmyl vmelcedgel keildrkghf senetrwiiq slasaiaylh nndivhrdlk
      241 lenimvkssl iddnneinln ikvtdfglav kkqsrseaml qatcgtpiym apevisahdy
      301 sqqcdiwsig vvmymllrge ppflasseek lfelirkgel hfenavwnsi sdcaksvlkq
      361 lmkvdpahri takelldnqw ltgnklssvr ptnvlemmke wknnpesvee ntteeknkps
      421 teeklksyqp wgnvpdanyt sdeeeekqdn aglrslra
//
LOCUS       XP_054225690             448 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase 33 isoform X4 [Homo sapiens].
ACCESSION   XP_054225690
VERSION     XP_054225690.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369715.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..448
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..448
                     /product="serine/threonine-protein kinase 33 isoform X4"
                     /calculated_mol_wt=50045
     Region          114..381
                     /region_name="STKc_STK33"
                     /note="Catalytic domain of Serine/Threonine Kinase 33;
                     cd14097"
                     /db_xref="CDD:270999"
     Site            order(122..126,130,143,145,176,192..195,199,201,237..238,
                     240,242..243,245,264..265,268,284..288,290)
                     /site_type="active"
                     /db_xref="CDD:270999"
     Site            order(122..125,130,143,145,176,192..195,199,242..243,245,
                     264..265)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270999"
     Site            order(126,199,201,237..238,240,242,268,284..288,290)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270999"
     Site            order(264..278,280..288)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270999"
     CDS             1..448
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /coded_by="XM_054369715.1:612..1958"
                     /db_xref="GeneID:65975"
                     /db_xref="HGNC:HGNC:14568"
                     /db_xref="MIM:607670"
ORIGIN      
        1 madsgldkks tkcpdcssas qkdvlcvcss ktrvppvlvv emsqtssigs aeslislerk
       61 kekninrdit srkdlpsrts nverkasqqq wgrgnftegk vphirienga aieeiytfgr
      121 ilgkgsfgiv ieatdketet kwaikkvnke kagssavkll erevnilksv khehiihleq
      181 vfetpkkmyl vmelcedgel keildrkghf senetrwiiq slasaiaylh nndivhrdlk
      241 lenimvkssl iddnneinln ikvtdfglav kkqsrseaml qatcgtpiym apevisahdy
      301 sqqcdiwsig vvmymllrge ppflasseek lfelirkgel hfenavwnsi sdcaksvlkq
      361 lmkvdpahri takelldnqw ltstayekqf patskdnfdm csssftsskl lpaeikgeme
      421 ktpvtpsqgt atkypaksga lsrtkkkl
//
LOCUS       XP_054225691             448 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase 33 isoform X4 [Homo sapiens].
ACCESSION   XP_054225691
VERSION     XP_054225691.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369716.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..448
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..448
                     /product="serine/threonine-protein kinase 33 isoform X4"
                     /calculated_mol_wt=50045
     Region          114..381
                     /region_name="STKc_STK33"
                     /note="Catalytic domain of Serine/Threonine Kinase 33;
                     cd14097"
                     /db_xref="CDD:270999"
     Site            order(122..126,130,143,145,176,192..195,199,201,237..238,
                     240,242..243,245,264..265,268,284..288,290)
                     /site_type="active"
                     /db_xref="CDD:270999"
     Site            order(122..125,130,143,145,176,192..195,199,242..243,245,
                     264..265)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270999"
     Site            order(126,199,201,237..238,240,242,268,284..288,290)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270999"
     Site            order(264..278,280..288)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270999"
     CDS             1..448
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /coded_by="XM_054369716.1:488..1834"
                     /db_xref="GeneID:65975"
                     /db_xref="HGNC:HGNC:14568"
                     /db_xref="MIM:607670"
ORIGIN      
        1 madsgldkks tkcpdcssas qkdvlcvcss ktrvppvlvv emsqtssigs aeslislerk
       61 kekninrdit srkdlpsrts nverkasqqq wgrgnftegk vphirienga aieeiytfgr
      121 ilgkgsfgiv ieatdketet kwaikkvnke kagssavkll erevnilksv khehiihleq
      181 vfetpkkmyl vmelcedgel keildrkghf senetrwiiq slasaiaylh nndivhrdlk
      241 lenimvkssl iddnneinln ikvtdfglav kkqsrseaml qatcgtpiym apevisahdy
      301 sqqcdiwsig vvmymllrge ppflasseek lfelirkgel hfenavwnsi sdcaksvlkq
      361 lmkvdpahri takelldnqw ltstayekqf patskdnfdm csssftsskl lpaeikgeme
      421 ktpvtpsqgt atkypaksga lsrtkkkl
//
LOCUS       XP_054225692             448 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase 33 isoform X4 [Homo sapiens].
ACCESSION   XP_054225692
VERSION     XP_054225692.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369717.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..448
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..448
                     /product="serine/threonine-protein kinase 33 isoform X4"
                     /calculated_mol_wt=50045
     Region          114..381
                     /region_name="STKc_STK33"
                     /note="Catalytic domain of Serine/Threonine Kinase 33;
                     cd14097"
                     /db_xref="CDD:270999"
     Site            order(122..126,130,143,145,176,192..195,199,201,237..238,
                     240,242..243,245,264..265,268,284..288,290)
                     /site_type="active"
                     /db_xref="CDD:270999"
     Site            order(122..125,130,143,145,176,192..195,199,242..243,245,
                     264..265)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270999"
     Site            order(126,199,201,237..238,240,242,268,284..288,290)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270999"
     Site            order(264..278,280..288)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270999"
     CDS             1..448
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /coded_by="XM_054369717.1:342..1688"
                     /db_xref="GeneID:65975"
                     /db_xref="HGNC:HGNC:14568"
                     /db_xref="MIM:607670"
ORIGIN      
        1 madsgldkks tkcpdcssas qkdvlcvcss ktrvppvlvv emsqtssigs aeslislerk
       61 kekninrdit srkdlpsrts nverkasqqq wgrgnftegk vphirienga aieeiytfgr
      121 ilgkgsfgiv ieatdketet kwaikkvnke kagssavkll erevnilksv khehiihleq
      181 vfetpkkmyl vmelcedgel keildrkghf senetrwiiq slasaiaylh nndivhrdlk
      241 lenimvkssl iddnneinln ikvtdfglav kkqsrseaml qatcgtpiym apevisahdy
      301 sqqcdiwsig vvmymllrge ppflasseek lfelirkgel hfenavwnsi sdcaksvlkq
      361 lmkvdpahri takelldnqw ltstayekqf patskdnfdm csssftsskl lpaeikgeme
      421 ktpvtpsqgt atkypaksga lsrtkkkl
//
LOCUS       XP_054225693             448 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase 33 isoform X4 [Homo sapiens].
ACCESSION   XP_054225693
VERSION     XP_054225693.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369718.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..448
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..448
                     /product="serine/threonine-protein kinase 33 isoform X4"
                     /calculated_mol_wt=50045
     Region          114..381
                     /region_name="STKc_STK33"
                     /note="Catalytic domain of Serine/Threonine Kinase 33;
                     cd14097"
                     /db_xref="CDD:270999"
     Site            order(122..126,130,143,145,176,192..195,199,201,237..238,
                     240,242..243,245,264..265,268,284..288,290)
                     /site_type="active"
                     /db_xref="CDD:270999"
     Site            order(122..125,130,143,145,176,192..195,199,242..243,245,
                     264..265)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270999"
     Site            order(126,199,201,237..238,240,242,268,284..288,290)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270999"
     Site            order(264..278,280..288)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270999"
     CDS             1..448
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /coded_by="XM_054369718.1:407..1753"
                     /db_xref="GeneID:65975"
                     /db_xref="HGNC:HGNC:14568"
                     /db_xref="MIM:607670"
ORIGIN      
        1 madsgldkks tkcpdcssas qkdvlcvcss ktrvppvlvv emsqtssigs aeslislerk
       61 kekninrdit srkdlpsrts nverkasqqq wgrgnftegk vphirienga aieeiytfgr
      121 ilgkgsfgiv ieatdketet kwaikkvnke kagssavkll erevnilksv khehiihleq
      181 vfetpkkmyl vmelcedgel keildrkghf senetrwiiq slasaiaylh nndivhrdlk
      241 lenimvkssl iddnneinln ikvtdfglav kkqsrseaml qatcgtpiym apevisahdy
      301 sqqcdiwsig vvmymllrge ppflasseek lfelirkgel hfenavwnsi sdcaksvlkq
      361 lmkvdpahri takelldnqw ltstayekqf patskdnfdm csssftsskl lpaeikgeme
      421 ktpvtpsqgt atkypaksga lsrtkkkl
//
LOCUS       XP_054225694             448 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase 33 isoform X4 [Homo sapiens].
ACCESSION   XP_054225694
VERSION     XP_054225694.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369719.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..448
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..448
                     /product="serine/threonine-protein kinase 33 isoform X4"
                     /calculated_mol_wt=50045
     Region          114..381
                     /region_name="STKc_STK33"
                     /note="Catalytic domain of Serine/Threonine Kinase 33;
                     cd14097"
                     /db_xref="CDD:270999"
     Site            order(122..126,130,143,145,176,192..195,199,201,237..238,
                     240,242..243,245,264..265,268,284..288,290)
                     /site_type="active"
                     /db_xref="CDD:270999"
     Site            order(122..125,130,143,145,176,192..195,199,242..243,245,
                     264..265)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270999"
     Site            order(126,199,201,237..238,240,242,268,284..288,290)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270999"
     Site            order(264..278,280..288)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270999"
     CDS             1..448
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /coded_by="XM_054369719.1:539..1885"
                     /db_xref="GeneID:65975"
                     /db_xref="HGNC:HGNC:14568"
                     /db_xref="MIM:607670"
ORIGIN      
        1 madsgldkks tkcpdcssas qkdvlcvcss ktrvppvlvv emsqtssigs aeslislerk
       61 kekninrdit srkdlpsrts nverkasqqq wgrgnftegk vphirienga aieeiytfgr
      121 ilgkgsfgiv ieatdketet kwaikkvnke kagssavkll erevnilksv khehiihleq
      181 vfetpkkmyl vmelcedgel keildrkghf senetrwiiq slasaiaylh nndivhrdlk
      241 lenimvkssl iddnneinln ikvtdfglav kkqsrseaml qatcgtpiym apevisahdy
      301 sqqcdiwsig vvmymllrge ppflasseek lfelirkgel hfenavwnsi sdcaksvlkq
      361 lmkvdpahri takelldnqw ltstayekqf patskdnfdm csssftsskl lpaeikgeme
      421 ktpvtpsqgt atkypaksga lsrtkkkl
//
LOCUS       XP_054225695             407 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase 33 isoform X5 [Homo sapiens].
ACCESSION   XP_054225695
VERSION     XP_054225695.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369720.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..407
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..407
                     /product="serine/threonine-protein kinase 33 isoform X5"
                     /calculated_mol_wt=45750
     Region          73..340
                     /region_name="STKc_STK33"
                     /note="Catalytic domain of Serine/Threonine Kinase 33;
                     cd14097"
                     /db_xref="CDD:270999"
     Site            order(81..85,89,102,104,135,151..154,158,160,196..197,199,
                     201..202,204,223..224,227,243..247,249)
                     /site_type="active"
                     /db_xref="CDD:270999"
     Site            order(81..84,89,102,104,135,151..154,158,201..202,204,
                     223..224)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270999"
     Site            order(85,158,160,196..197,199,201,227,243..247,249)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270999"
     Site            order(223..237,239..247)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270999"
     CDS             1..407
                     /gene="STK33"
                     /gene_synonym="SPGF93"
                     /coded_by="XM_054369720.1:296..1519"
                     /db_xref="GeneID:65975"
                     /db_xref="HGNC:HGNC:14568"
                     /db_xref="MIM:607670"
ORIGIN      
        1 msqtssigsa eslislerkk ekninrdits rkdlpsrtsn verkasqqqw grgnftegkv
       61 phiriengaa ieeiytfgri lgkgsfgivi eatdketetk waikkvnkek agssavklle
      121 revnilksvk hehiihleqv fetpkkmylv melcedgelk eildrkghfs enetrwiiqs
      181 lasaiaylhn ndivhrdlkl enimvkssli ddnneinlni kvtdfglavk kqsrseamlq
      241 atcgtpiyma pevisahdys qqcdiwsigv vmymllrgep pflasseekl felirkgelh
      301 fenavwnsis dcaksvlkql mkvdpahrit akelldnqwl tstayekqfp atskdnfdmc
      361 sssftsskll paeikgemek tpvtpsqgta tkypaksgal srtkkkl
//
LOCUS       XP_054225696             549 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger translocation-associated protein isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225696
VERSION     XP_054225696.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369721.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 6% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..549
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..549
                     /product="zinc finger translocation-associated protein
                     isoform X1"
                     /calculated_mol_wt=59074
     Region          106..169
                     /region_name="zf-C2H2_12"
                     /note="Spin-doc zinc-finger; pfam18658"
                     /db_xref="CDD:465831"
     Region          290..353
                     /region_name="zf-C2H2_12"
                     /note="Spin-doc zinc-finger; pfam18658"
                     /db_xref="CDD:465831"
     Region          453..516
                     /region_name="zf-C2H2_12"
                     /note="Spin-doc zinc-finger; pfam18658"
                     /db_xref="CDD:465831"
     CDS             1..549
                     /gene="ZFTA"
                     /gene_synonym="C11orf95"
                     /coded_by="XM_054369721.1:154..1803"
                     /db_xref="GeneID:65998"
                     /db_xref="HGNC:HGNC:28449"
                     /db_xref="MIM:615699"
ORIGIN      
        1 mepggdhrsr ssggrggpgp avasargrrl ppagssgsae peedeggqdl qleggalgsw
       61 gsaplpssra rgpassgrky sdhcearasr pgksripgrd hrryyhdhwr leylmdfnpa
      121 rhgmvcmvcg sslatlklst ikrhirqkhp yslhwsprek evisnswdah lglgacgeae
      181 glgvqgaeee eeeeeeeeee gagvpacppk gpgddlapqd ltgksrdsas aagapssqdl
      241 sppdvkeeag wvperpgpae eeeeleegeg eragvpgrsp rgrahrrhpq erwrleylme
      301 ldggrrglvc gvcggalasl kmstierhir rrhpgstrlg gpvqaliare wsekaahlla
      361 lgpprpespq gpippgtaaa sdegggdeee epeeeeeewg dvplspgapl erpaeeeede
      421 edgqepggla lppppppppp ppprsreqrr nyqprwrgey lmdydgsrrg lvcmvcggal
      481 atlkvstikr hilqvhpfsm dftpeerqti leayeeaalr cyghegfgpp apaprdggad
      541 lksgavcra
//
LOCUS       XP_054225697             491 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger translocation-associated protein isoform X2 [Homo
            sapiens].
ACCESSION   XP_054225697
VERSION     XP_054225697.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369722.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..491
                     /product="zinc finger translocation-associated protein
                     isoform X2"
                     /calculated_mol_wt=52974
     Region          106..169
                     /region_name="zf-C2H2_12"
                     /note="Spin-doc zinc-finger; pfam18658"
                     /db_xref="CDD:465831"
     Region          265..326
                     /region_name="zf-C2H2_12"
                     /note="Spin-doc zinc-finger; pfam18658"
                     /db_xref="CDD:465831"
     Region          395..458
                     /region_name="zf-C2H2_12"
                     /note="Spin-doc zinc-finger; pfam18658"
                     /db_xref="CDD:465831"
     CDS             1..491
                     /gene="ZFTA"
                     /gene_synonym="C11orf95"
                     /coded_by="XM_054369722.1:154..1629"
                     /db_xref="GeneID:65998"
                     /db_xref="HGNC:HGNC:28449"
                     /db_xref="MIM:615699"
ORIGIN      
        1 mepggdhrsr ssggrggpgp avasargrrl ppagssgsae peedeggqdl qleggalgsw
       61 gsaplpssra rgpassgrky sdhcearasr pgksripgrd hrryyhdhwr leylmdfnpa
      121 rhgmvcmvcg sslatlklst ikrhirqkhp yslhwsprek evisnswdah lglgacgeae
      181 glgvqgaeee eeeeeeeeee gagvpacppk gpgkapaggg crrqrrggpv aprarrlrls
      241 asrraggsrg lgarrlerrl keslqnwfra eclmdydprg nrlvcmacgr alpslhlddi
      301 rahvlevhpg slglsgpqrs allqawggqp ealseltqsp pgdvplspga plerpaeeee
      361 deedgqepgg lalppppppp ppppprsreq rrnyqprwrg eylmdydgsr rglvcmvcgg
      421 alatlkvsti krhilqvhpf smdftpeerq tileayeeaa lrcyghegfg ppapaprdgg
      481 adlksgavcr a
//
LOCUS       XP_054225698             362 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger translocation-associated protein isoform X3 [Homo
            sapiens].
ACCESSION   XP_054225698
VERSION     XP_054225698.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369723.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..362
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..362
                     /product="zinc finger translocation-associated protein
                     isoform X3"
                     /calculated_mol_wt=38981
     Region          106..169
                     /region_name="zf-C2H2_12"
                     /note="Spin-doc zinc-finger; pfam18658"
                     /db_xref="CDD:465831"
     Region          266..329
                     /region_name="zf-C2H2_12"
                     /note="Spin-doc zinc-finger; pfam18658"
                     /db_xref="CDD:465831"
     CDS             1..362
                     /gene="ZFTA"
                     /gene_synonym="C11orf95"
                     /coded_by="XM_054369723.1:154..1242"
                     /db_xref="GeneID:65998"
                     /db_xref="HGNC:HGNC:28449"
                     /db_xref="MIM:615699"
ORIGIN      
        1 mepggdhrsr ssggrggpgp avasargrrl ppagssgsae peedeggqdl qleggalgsw
       61 gsaplpssra rgpassgrky sdhcearasr pgksripgrd hrryyhdhwr leylmdfnpa
      121 rhgmvcmvcg sslatlklst ikrhirqkhp yslhwsprek evisnswdah lglgacgeae
      181 glgvqgaeee eeeeeeeeee gagvpacppk gpgdvplspg aplerpaeee edeedgqepg
      241 glalpppppp pppppprsre qrrnyqprwr geylmdydgs rrglvcmvcg galatlkvst
      301 ikrhilqvhp fsmdftpeer qtileayeea alrcyghegf gppapaprdg gadlksgavc
      361 ra
//
LOCUS       XP_054225699             478 aa            linear   PRI 05-AUG-2025
DEFINITION  chitinase domain-containing protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_054225699
VERSION     XP_054225699.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369724.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..478
                     /product="chitinase domain-containing protein 1 isoform
                     X1"
                     /calculated_mol_wt=53307
     Region          162..478
                     /region_name="GH18_SI-CLP"
                     /note="Stabilin-1 interacting chitinase-like protein
                     (SI-CLP) is a eukaryotic chitinase-like protein of unknown
                     function that interacts with the endocytic/sorting
                     transmembrane receptor stabilin-1 and is secreted from the
                     lysosome. SI-CLP has a glycosyl...; cd02876"
                     /db_xref="CDD:119355"
     Site            order(169,195,275,277,279,346..347,465)
                     /site_type="other"
                     /note="putative carbohydrate binding site [chemical
                     binding]"
                     /db_xref="CDD:119355"
     CDS             1..478
                     /gene="CHID1"
                     /gene_synonym="GL008; SI-CLP; SICLP"
                     /coded_by="XM_054369724.1:200..1636"
                     /db_xref="GeneID:66005"
                     /db_xref="HGNC:HGNC:28474"
                     /db_xref="MIM:615692"
ORIGIN      
        1 mgspkagiqs aaetlisagl ltppacpcpt lsppcprqtg sgqaggpqgr sdlglqgraw
       61 tsaralhthp gpldpevgpy cdtptmrtlf nllwlalacs pvhttlsksd akkaasktll
      121 eksqfsdkpv qdrglvvtdl kaesvvlehr sycsakardr hfagdvlgyv tpwnshgydv
      181 tkvfgskftq ispvwlqlkr rgremfevtg lhdvdqgwmr avrkhakglh ivprllfedw
      241 tyddfrnvld sedeieelsk tvvqvaknqh fdgfvvevwn qllsqkrvgl ihmlthlaea
      301 lhqarllall vippaitpgt dqlgmfthke feqlapvldg fslmtydyst ahqpgpnapl
      361 swvracvqvl dpkskwrski llglnfygmd yatskdarep vvgaryiqtl kdhrpqmvwd
      421 sqvsehffey kksrsgrhvv fyptlkslqv rlelarelgv gvsiwelgqg ldyfydll
//
LOCUS       XP_054225700             447 aa            linear   PRI 05-AUG-2025
DEFINITION  chitinase domain-containing protein 1 isoform X2 [Homo sapiens].
ACCESSION   XP_054225700
VERSION     XP_054225700.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369725.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..447
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..447
                     /product="chitinase domain-containing protein 1 isoform
                     X2"
                     /calculated_mol_wt=50044
     Region          162..447
                     /region_name="GH18_SI-CLP"
                     /note="Stabilin-1 interacting chitinase-like protein
                     (SI-CLP) is a eukaryotic chitinase-like protein of unknown
                     function that interacts with the endocytic/sorting
                     transmembrane receptor stabilin-1 and is secreted from the
                     lysosome. SI-CLP has a glycosyl...; cd02876"
                     /db_xref="CDD:119355"
     Site            order(169,195,275,277,279,315..316,434)
                     /site_type="other"
                     /note="putative carbohydrate binding site [chemical
                     binding]"
                     /db_xref="CDD:119355"
     CDS             1..447
                     /gene="CHID1"
                     /gene_synonym="GL008; SI-CLP; SICLP"
                     /coded_by="XM_054369725.1:200..1543"
                     /db_xref="GeneID:66005"
                     /db_xref="HGNC:HGNC:28474"
                     /db_xref="MIM:615692"
ORIGIN      
        1 mgspkagiqs aaetlisagl ltppacpcpt lsppcprqtg sgqaggpqgr sdlglqgraw
       61 tsaralhthp gpldpevgpy cdtptmrtlf nllwlalacs pvhttlsksd akkaasktll
      121 eksqfsdkpv qdrglvvtdl kaesvvlehr sycsakardr hfagdvlgyv tpwnshgydv
      181 tkvfgskftq ispvwlqlkr rgremfevtg lhdvdqgwmr avrkhakglh ivprllfedw
      241 tyddfrnvld sedeieelsk tvvqvaknqh fdgfvvevwn qllsqkrvtd qlgmfthkef
      301 eqlapvldgf slmtydysta hqpgpnapls wvracvqvld pkskwrskil lglnfygmdy
      361 atskdarepv vgaryiqtlk dhrpqmvwds qvsehffeyk ksrsgrhvvf yptlkslqvr
      421 lelarelgvg vsiwelgqgl dyfydll
//
LOCUS       XP_054225701             447 aa            linear   PRI 05-AUG-2025
DEFINITION  chitinase domain-containing protein 1 isoform X3 [Homo sapiens].
ACCESSION   XP_054225701
VERSION     XP_054225701.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369726.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..447
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..447
                     /product="chitinase domain-containing protein 1 isoform
                     X3"
                     /calculated_mol_wt=49159
     Region          162..>405
                     /region_name="GH18_SI-CLP"
                     /note="Stabilin-1 interacting chitinase-like protein
                     (SI-CLP) is a eukaryotic chitinase-like protein of unknown
                     function that interacts with the endocytic/sorting
                     transmembrane receptor stabilin-1 and is secreted from the
                     lysosome. SI-CLP has a glycosyl...; cd02876"
                     /db_xref="CDD:119355"
     Site            order(169,195,275,277,279,346..347)
                     /site_type="other"
                     /note="putative carbohydrate binding site [chemical
                     binding]"
                     /db_xref="CDD:119355"
     CDS             1..447
                     /gene="CHID1"
                     /gene_synonym="GL008; SI-CLP; SICLP"
                     /coded_by="XM_054369726.1:200..1543"
                     /db_xref="GeneID:66005"
                     /db_xref="HGNC:HGNC:28474"
                     /db_xref="MIM:615692"
ORIGIN      
        1 mgspkagiqs aaetlisagl ltppacpcpt lsppcprqtg sgqaggpqgr sdlglqgraw
       61 tsaralhthp gpldpevgpy cdtptmrtlf nllwlalacs pvhttlsksd akkaasktll
      121 eksqfsdkpv qdrglvvtdl kaesvvlehr sycsakardr hfagdvlgyv tpwnshgydv
      181 tkvfgskftq ispvwlqlkr rgremfevtg lhdvdqgwmr avrkhakglh ivprllfedw
      241 tyddfrnvld sedeieelsk tvvqvaknqh fdgfvvevwn qllsqkrvgl ihmlthlaea
      301 lhqarllall vippaitpgt dqlgmfthke feqlapvldg fslmtydyst ahqpgpnapl
      361 swvracvqvl dpkskwrski llglnfygmd yatskdarep vvgarklctt rlcllsaasr
      421 trnrflmvaq ggsqhtmtal plepgqp
//
LOCUS       XP_054225702             410 aa            linear   PRI 05-AUG-2025
DEFINITION  chitinase domain-containing protein 1 isoform X4 [Homo sapiens].
ACCESSION   XP_054225702
VERSION     XP_054225702.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369727.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..410
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..410
                     /product="chitinase domain-containing protein 1 isoform
                     X4"
                     /calculated_mol_wt=45003
     Region          162..>404
                     /region_name="GH18_SI-CLP"
                     /note="Stabilin-1 interacting chitinase-like protein
                     (SI-CLP) is a eukaryotic chitinase-like protein of unknown
                     function that interacts with the endocytic/sorting
                     transmembrane receptor stabilin-1 and is secreted from the
                     lysosome. SI-CLP has a glycosyl...; cd02876"
                     /db_xref="CDD:119355"
     Site            order(169,195,275,277,279,346..347)
                     /site_type="other"
                     /note="putative carbohydrate binding site [chemical
                     binding]"
                     /db_xref="CDD:119355"
     CDS             1..410
                     /gene="CHID1"
                     /gene_synonym="GL008; SI-CLP; SICLP"
                     /coded_by="XM_054369727.1:200..1432"
                     /db_xref="GeneID:66005"
                     /db_xref="HGNC:HGNC:28474"
                     /db_xref="MIM:615692"
ORIGIN      
        1 mgspkagiqs aaetlisagl ltppacpcpt lsppcprqtg sgqaggpqgr sdlglqgraw
       61 tsaralhthp gpldpevgpy cdtptmrtlf nllwlalacs pvhttlsksd akkaasktll
      121 eksqfsdkpv qdrglvvtdl kaesvvlehr sycsakardr hfagdvlgyv tpwnshgydv
      181 tkvfgskftq ispvwlqlkr rgremfevtg lhdvdqgwmr avrkhakglh ivprllfedw
      241 tyddfrnvld sedeieelsk tvvqvaknqh fdgfvvevwn qllsqkrvgl ihmlthlaea
      301 lhqarllall vippaitpgt dqlgmfthke feqlapvldg fslmtydyst ahqpgpnapl
      361 swvracvqvl dpkskwrski llglnfygmd yatskdarep vvgasvhgas
//
LOCUS       XP_054225703             393 aa            linear   PRI 05-AUG-2025
DEFINITION  chitinase domain-containing protein 1 isoform X5 [Homo sapiens].
ACCESSION   XP_054225703
VERSION     XP_054225703.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369728.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 1% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..393
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..393
                     /product="chitinase domain-containing protein 1 isoform
                     X5"
                     /calculated_mol_wt=44810
     Region          77..393
                     /region_name="GH18_SI-CLP"
                     /note="Stabilin-1 interacting chitinase-like protein
                     (SI-CLP) is a eukaryotic chitinase-like protein of unknown
                     function that interacts with the endocytic/sorting
                     transmembrane receptor stabilin-1 and is secreted from the
                     lysosome. SI-CLP has a glycosyl...; cd02876"
                     /db_xref="CDD:119355"
     Site            order(84,110,190,192,194,261..262,380)
                     /site_type="other"
                     /note="putative carbohydrate binding site [chemical
                     binding]"
                     /db_xref="CDD:119355"
     CDS             1..393
                     /gene="CHID1"
                     /gene_synonym="GL008; SI-CLP; SICLP"
                     /coded_by="XM_054369728.1:249..1430"
                     /db_xref="GeneID:66005"
                     /db_xref="HGNC:HGNC:28474"
                     /db_xref="MIM:615692"
ORIGIN      
        1 mrtlfnllwl alacspvhtt lsksdakkaa sktlleksqf sdkpvqdrgl vvtdlkaesv
       61 vlehrsycsa kardrhfagd vlgyvtpwns hgydvtkvfg skftqispvw lqlkrrgrem
      121 fevtglhdvd qgwmravrkh akglhivprl lfedwtyddf rnvldsedei eelsktvvqv
      181 aknqhfdgfv vevwnqllsq krvglihmlt hlaealhqar llallvippa itpgtdqlgm
      241 fthkefeqla pvldgfslmt ydystahqpg pnaplswvra cvqvldpksk wrskillgln
      301 fygmdyatsk darepvvgar yiqtlkdhrp qmvwdsqvse hffeykksrs grhvvfyptl
      361 kslqvrlela relgvgvsiw elgqgldyfy dll
//
LOCUS       XP_054225704             379 aa            linear   PRI 05-AUG-2025
DEFINITION  chitinase domain-containing protein 1 isoform X6 [Homo sapiens].
ACCESSION   XP_054225704
VERSION     XP_054225704.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369729.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..379
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..379
                     /product="chitinase domain-containing protein 1 isoform
                     X6"
                     /calculated_mol_wt=41740
     Region          162..>373
                     /region_name="GH18_chitinase-like"
                     /note="The GH18 (glycosyl hydrolase, family 18) type II
                     chitinases hydrolyze chitin, an abundant polymer of
                     beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a
                     major component of the cell wall of fungi and the
                     exoskeleton of arthropods. Chitinases have...; cl10447"
                     /db_xref="CDD:471972"
     Site            order(168,195,275,277,279,315..316,356)
                     /site_type="active"
                     /db_xref="CDD:119349"
     CDS             1..379
                     /gene="CHID1"
                     /gene_synonym="GL008; SI-CLP; SICLP"
                     /coded_by="XM_054369729.1:200..1339"
                     /db_xref="GeneID:66005"
                     /db_xref="HGNC:HGNC:28474"
                     /db_xref="MIM:615692"
ORIGIN      
        1 mgspkagiqs aaetlisagl ltppacpcpt lsppcprqtg sgqaggpqgr sdlglqgraw
       61 tsaralhthp gpldpevgpy cdtptmrtlf nllwlalacs pvhttlsksd akkaasktll
      121 eksqfsdkpv qdrglvvtdl kaesvvlehr sycsakardr hfagdvlgyv tpwnshgydv
      181 tkvfgskftq ispvwlqlkr rgremfevtg lhdvdqgwmr avrkhakglh ivprllfedw
      241 tyddfrnvld sedeieelsk tvvqvaknqh fdgfvvevwn qllsqkrvtd qlgmfthkef
      301 eqlapvldgf slmtydysta hqpgpnapls wvracvqvld pkskwrskil lglnfygmdy
      361 atskdarepv vgasvhgas
//
LOCUS       XP_054225705             362 aa            linear   PRI 05-AUG-2025
DEFINITION  chitinase domain-containing protein 1 isoform X7 [Homo sapiens].
ACCESSION   XP_054225705
VERSION     XP_054225705.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369730.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..362
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..362
                     /product="chitinase domain-containing protein 1 isoform
                     X7"
                     /calculated_mol_wt=40661
     Region          77..>320
                     /region_name="GH18_SI-CLP"
                     /note="Stabilin-1 interacting chitinase-like protein
                     (SI-CLP) is a eukaryotic chitinase-like protein of unknown
                     function that interacts with the endocytic/sorting
                     transmembrane receptor stabilin-1 and is secreted from the
                     lysosome. SI-CLP has a glycosyl...; cd02876"
                     /db_xref="CDD:119355"
     Site            order(84,110,190,192,194,261..262)
                     /site_type="other"
                     /note="putative carbohydrate binding site [chemical
                     binding]"
                     /db_xref="CDD:119355"
     CDS             1..362
                     /gene="CHID1"
                     /gene_synonym="GL008; SI-CLP; SICLP"
                     /coded_by="XM_054369730.1:80..1168"
                     /db_xref="GeneID:66005"
                     /db_xref="HGNC:HGNC:28474"
                     /db_xref="MIM:615692"
ORIGIN      
        1 mrtlfnllwl alacspvhtt lsksdakkaa sktlleksqf sdkpvqdrgl vvtdlkaesv
       61 vlehrsycsa kardrhfagd vlgyvtpwns hgydvtkvfg skftqispvw lqlkrrgrem
      121 fevtglhdvd qgwmravrkh akglhivprl lfedwtyddf rnvldsedei eelsktvvqv
      181 aknqhfdgfv vevwnqllsq krvglihmlt hlaealhqar llallvippa itpgtdqlgm
      241 fthkefeqla pvldgfslmt ydystahqpg pnaplswvra cvqvldpksk wrskillgln
      301 fygmdyatsk darepvvgar klcttrlcll saasrtrnrf lmvaqggsqh tmtalplepg
      361 qp
//
LOCUS       XP_054225706             362 aa            linear   PRI 05-AUG-2025
DEFINITION  chitinase domain-containing protein 1 isoform X8 [Homo sapiens].
ACCESSION   XP_054225706
VERSION     XP_054225706.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369731.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..362
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..362
                     /product="chitinase domain-containing protein 1 isoform
                     X8"
                     /calculated_mol_wt=41547
     Region          77..362
                     /region_name="GH18_SI-CLP"
                     /note="Stabilin-1 interacting chitinase-like protein
                     (SI-CLP) is a eukaryotic chitinase-like protein of unknown
                     function that interacts with the endocytic/sorting
                     transmembrane receptor stabilin-1 and is secreted from the
                     lysosome. SI-CLP has a glycosyl...; cd02876"
                     /db_xref="CDD:119355"
     Site            order(84,110,190,192,194,230..231,349)
                     /site_type="other"
                     /note="putative carbohydrate binding site [chemical
                     binding]"
                     /db_xref="CDD:119355"
     CDS             1..362
                     /gene="CHID1"
                     /gene_synonym="GL008; SI-CLP; SICLP"
                     /coded_by="XM_054369731.1:145..1233"
                     /db_xref="GeneID:66005"
                     /db_xref="HGNC:HGNC:28474"
                     /db_xref="MIM:615692"
ORIGIN      
        1 mrtlfnllwl alacspvhtt lsksdakkaa sktlleksqf sdkpvqdrgl vvtdlkaesv
       61 vlehrsycsa kardrhfagd vlgyvtpwns hgydvtkvfg skftqispvw lqlkrrgrem
      121 fevtglhdvd qgwmravrkh akglhivprl lfedwtyddf rnvldsedei eelsktvvqv
      181 aknqhfdgfv vevwnqllsq krvtdqlgmf thkefeqlap vldgfslmty dystahqpgp
      241 naplswvrac vqvldpkskw rskillglnf ygmdyatskd arepvvgary iqtlkdhrpq
      301 mvwdsqvseh ffeykksrsg rhvvfyptlk slqvrlelar elgvgvsiwe lgqgldyfyd
      361 ll
//
LOCUS       XP_054225707             331 aa            linear   PRI 05-AUG-2025
DEFINITION  chitinase domain-containing protein 1 isoform X9 [Homo sapiens].
ACCESSION   XP_054225707
VERSION     XP_054225707.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369732.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..331
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..331
                     /product="chitinase domain-containing protein 1 isoform
                     X9"
                     /calculated_mol_wt=37398
     Region          77..>289
                     /region_name="GH18_chitinase-like"
                     /note="The GH18 (glycosyl hydrolase, family 18) type II
                     chitinases hydrolyze chitin, an abundant polymer of
                     beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a
                     major component of the cell wall of fungi and the
                     exoskeleton of arthropods. Chitinases have...; cl10447"
                     /db_xref="CDD:471972"
     Site            order(83,110,190,192,194,230..231,271)
                     /site_type="active"
                     /db_xref="CDD:119349"
     CDS             1..331
                     /gene="CHID1"
                     /gene_synonym="GL008; SI-CLP; SICLP"
                     /coded_by="XM_054369732.1:80..1075"
                     /db_xref="GeneID:66005"
                     /db_xref="HGNC:HGNC:28474"
                     /db_xref="MIM:615692"
ORIGIN      
        1 mrtlfnllwl alacspvhtt lsksdakkaa sktlleksqf sdkpvqdrgl vvtdlkaesv
       61 vlehrsycsa kardrhfagd vlgyvtpwns hgydvtkvfg skftqispvw lqlkrrgrem
      121 fevtglhdvd qgwmravrkh akglhivprl lfedwtyddf rnvldsedei eelsktvvqv
      181 aknqhfdgfv vevwnqllsq krvtdqlgmf thkefeqlap vldgfslmty dystahqpgp
      241 naplswvrac vqvldpkskw rskillglnf ygmdyatskd arepvvgark lcttrlclls
      301 aasrtrnrfl mvaqggsqht mtalplepgq p
//
LOCUS       XP_054225708             325 aa            linear   PRI 05-AUG-2025
DEFINITION  chitinase domain-containing protein 1 isoform X10 [Homo sapiens].
ACCESSION   XP_054225708
VERSION     XP_054225708.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369733.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..325
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..325
                     /product="chitinase domain-containing protein 1 isoform
                     X10"
                     /calculated_mol_wt=36505
     Region          77..>319
                     /region_name="GH18_SI-CLP"
                     /note="Stabilin-1 interacting chitinase-like protein
                     (SI-CLP) is a eukaryotic chitinase-like protein of unknown
                     function that interacts with the endocytic/sorting
                     transmembrane receptor stabilin-1 and is secreted from the
                     lysosome. SI-CLP has a glycosyl...; cd02876"
                     /db_xref="CDD:119355"
     Site            order(84,110,190,192,194,261..262)
                     /site_type="other"
                     /note="putative carbohydrate binding site [chemical
                     binding]"
                     /db_xref="CDD:119355"
     CDS             1..325
                     /gene="CHID1"
                     /gene_synonym="GL008; SI-CLP; SICLP"
                     /coded_by="XM_054369733.1:80..1057"
                     /db_xref="GeneID:66005"
                     /db_xref="HGNC:HGNC:28474"
                     /db_xref="MIM:615692"
ORIGIN      
        1 mrtlfnllwl alacspvhtt lsksdakkaa sktlleksqf sdkpvqdrgl vvtdlkaesv
       61 vlehrsycsa kardrhfagd vlgyvtpwns hgydvtkvfg skftqispvw lqlkrrgrem
      121 fevtglhdvd qgwmravrkh akglhivprl lfedwtyddf rnvldsedei eelsktvvqv
      181 aknqhfdgfv vevwnqllsq krvglihmlt hlaealhqar llallvippa itpgtdqlgm
      241 fthkefeqla pvldgfslmt ydystahqpg pnaplswvra cvqvldpksk wrskillgln
      301 fygmdyatsk darepvvgas vhgas
//
LOCUS       XP_054225709             325 aa            linear   PRI 05-AUG-2025
DEFINITION  chitinase domain-containing protein 1 isoform X10 [Homo sapiens].
ACCESSION   XP_054225709
VERSION     XP_054225709.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369734.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..325
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..325
                     /product="chitinase domain-containing protein 1 isoform
                     X10"
                     /calculated_mol_wt=36505
     Region          77..>319
                     /region_name="GH18_SI-CLP"
                     /note="Stabilin-1 interacting chitinase-like protein
                     (SI-CLP) is a eukaryotic chitinase-like protein of unknown
                     function that interacts with the endocytic/sorting
                     transmembrane receptor stabilin-1 and is secreted from the
                     lysosome. SI-CLP has a glycosyl...; cd02876"
                     /db_xref="CDD:119355"
     Site            order(84,110,190,192,194,261..262)
                     /site_type="other"
                     /note="putative carbohydrate binding site [chemical
                     binding]"
                     /db_xref="CDD:119355"
     CDS             1..325
                     /gene="CHID1"
                     /gene_synonym="GL008; SI-CLP; SICLP"
                     /coded_by="XM_054369734.1:145..1122"
                     /db_xref="GeneID:66005"
                     /db_xref="HGNC:HGNC:28474"
                     /db_xref="MIM:615692"
ORIGIN      
        1 mrtlfnllwl alacspvhtt lsksdakkaa sktlleksqf sdkpvqdrgl vvtdlkaesv
       61 vlehrsycsa kardrhfagd vlgyvtpwns hgydvtkvfg skftqispvw lqlkrrgrem
      121 fevtglhdvd qgwmravrkh akglhivprl lfedwtyddf rnvldsedei eelsktvvqv
      181 aknqhfdgfv vevwnqllsq krvglihmlt hlaealhqar llallvippa itpgtdqlgm
      241 fthkefeqla pvldgfslmt ydystahqpg pnaplswvra cvqvldpksk wrskillgln
      301 fygmdyatsk darepvvgas vhgas
//
LOCUS       XP_054225710             294 aa            linear   PRI 05-AUG-2025
DEFINITION  chitinase domain-containing protein 1 isoform X11 [Homo sapiens].
ACCESSION   XP_054225710
VERSION     XP_054225710.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369735.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..294
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..294
                     /product="chitinase domain-containing protein 1 isoform
                     X11"
                     /calculated_mol_wt=33242
     Region          77..>288
                     /region_name="GH18_chitinase-like"
                     /note="The GH18 (glycosyl hydrolase, family 18) type II
                     chitinases hydrolyze chitin, an abundant polymer of
                     beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a
                     major component of the cell wall of fungi and the
                     exoskeleton of arthropods. Chitinases have...; cl10447"
                     /db_xref="CDD:471972"
     Site            order(83,110,190,192,194,230..231,271)
                     /site_type="active"
                     /db_xref="CDD:119349"
     CDS             1..294
                     /gene="CHID1"
                     /gene_synonym="GL008; SI-CLP; SICLP"
                     /coded_by="XM_054369735.1:80..964"
                     /db_xref="GeneID:66005"
                     /db_xref="HGNC:HGNC:28474"
                     /db_xref="MIM:615692"
ORIGIN      
        1 mrtlfnllwl alacspvhtt lsksdakkaa sktlleksqf sdkpvqdrgl vvtdlkaesv
       61 vlehrsycsa kardrhfagd vlgyvtpwns hgydvtkvfg skftqispvw lqlkrrgrem
      121 fevtglhdvd qgwmravrkh akglhivprl lfedwtyddf rnvldsedei eelsktvvqv
      181 aknqhfdgfv vevwnqllsq krvtdqlgmf thkefeqlap vldgfslmty dystahqpgp
      241 naplswvrac vqvldpkskw rskillglnf ygmdyatskd arepvvgasv hgas
//
LOCUS       XP_054225711             464 aa            linear   PRI 05-AUG-2025
DEFINITION  sphingomyelin phosphodiesterase isoform X1 [Homo sapiens].
ACCESSION   XP_054225711
VERSION     XP_054225711.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369736.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..464
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..464
                     /product="sphingomyelin phosphodiesterase isoform X1"
                     /calculated_mol_wt=50780
     Region          89..162
                     /region_name="SapB"
                     /note="Saposin (B) Domains; smart00741"
                     /db_xref="CDD:214797"
     Region          203..451
                     /region_name="MPP_ASMase"
                     /note="acid sphingomyelinase and related proteins,
                     metallophosphatase domain; cd00842"
                     /db_xref="CDD:277321"
     Site            order(208,210,280,320..321,383,415,417)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:277321"
     Site            order(208,210,280,320,383,415,417)
                     /site_type="other"
                     /note="putative metal binding site [ion binding]"
                     /db_xref="CDD:277321"
     CDS             1..464
                     /gene="SMPD1"
                     /gene_synonym="ASM; ASMASE; NPD"
                     /coded_by="XM_054369736.1:126..1520"
                     /db_xref="GeneID:6609"
                     /db_xref="HGNC:HGNC:11120"
                     /db_xref="MIM:607608"
ORIGIN      
        1 mprygaslrq scprsgreqg qdgtagapgl lwmglalala lalalalals dsrvlwapae
       61 ahplspqghp arlhrivprl rdvfgwgnlt cpickglfta inlglkkepn varvgsvaik
      121 lcnllkiapp avcqsivhlf eddmvevwrr svlspseacg lllgstcghw difsswnisl
      181 ptvpkpppkp psppapgapv srilfltdlh wdhdylegtd pdcadplccr rgsglppasr
      241 pgagywgeys kcdlplrtle sllsglgpag pfdmvywtgd ipahdvwhqt rqdqlraltt
      301 vtalvrkflg pvpvypavgn hestpvnsfp ppfiegnhss rwlyeamaka wepwlpaeal
      361 rtlrylssve tqegkrkvhi ighippghcl kswswnyyri varyentlaa qffghthvde
      421 fevfydeetl srplavafla psattyigln pvsptslqvt vctk
//
LOCUS       XP_054225712             324 aa            linear   PRI 05-AUG-2025
DEFINITION  sphingomyelin phosphodiesterase isoform X2 [Homo sapiens].
ACCESSION   XP_054225712
VERSION     XP_054225712.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369737.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..324
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..324
                     /product="sphingomyelin phosphodiesterase isoform X2"
                     /calculated_mol_wt=36388
     Region          <47..191
                     /region_name="MPP_ASMase"
                     /note="acid sphingomyelinase and related proteins,
                     metallophosphatase domain; cd00842"
                     /db_xref="CDD:277321"
     Region          169..290
                     /region_name="ASMase_C"
                     /note="Acid sphingomyelin phosphodiesterase C-terminal
                     region; pfam19272"
                     /db_xref="CDD:466022"
     CDS             1..324
                     /gene="SMPD1"
                     /gene_synonym="ASM; ASMASE; NPD"
                     /coded_by="XM_054369737.1:646..1620"
                     /db_xref="GeneID:6609"
                     /db_xref="HGNC:HGNC:11120"
                     /db_xref="MIM:607608"
ORIGIN      
        1 mkahlsiasl ppslrattpp agsmkrwprl gspgclpkpc apsgtyrpwk prkgkerigg
       61 fyalspypgl rlislnmnfc srenfwllin stdpagqlqw lvgelqaaed rgdkvhiigh
      121 ippghclksw swnyyrivar yentlaaqff ghthvdefev fydeetlsrp lavaflapsa
      181 ttyiglnpgy rvyqidgnys gsshvvldhe tyilnltqan ipgaiphwql lyraretygl
      241 pntlptawhn lvyrmrgdmq lfqtfwflyh kghppsepcg tpcrlatlca qlsaradspa
      301 lcrhlmpdgs lpeaqslwpr plfc
//
LOCUS       XP_054225713             183 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor PU.1 isoform X1 [Homo sapiens].
ACCESSION   XP_054225713
VERSION     XP_054225713.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369738.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..183
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..183
                     /product="transcription factor PU.1 isoform X1"
                     /calculated_mol_wt=20576
     Region          84..165
                     /region_name="Ets"
                     /note="Ets-domain; pfam00178"
                     /db_xref="CDD:459700"
     CDS             1..183
                     /gene="SPI1"
                     /gene_synonym="AGM10; OF; PU.1; SFPI1; SPI-1; SPI-A"
                     /coded_by="XM_054369738.1:322..873"
                     /db_xref="GeneID:6688"
                     /db_xref="HGNC:HGNC:11241"
                     /db_xref="MIM:165170"
ORIGIN      
        1 meleqmhvld tpmvpphpsl ghqvsylprm clqypslspa qpssdeeege rqspplevsd
       61 geadglepgp gllpgetgsk kkirlyqfll dllrsgdmkd siwwvdkdkg tfqfsskhke
      121 alahrwgiqk gnrkkmtyqk maralrnygk tgevkkvkkk ltyqfsgevl grgglaerrh
      181 pph
//
LOCUS       XP_054225714             183 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor PU.1 isoform X1 [Homo sapiens].
ACCESSION   XP_054225714
VERSION     XP_054225714.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369739.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..183
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..183
                     /product="transcription factor PU.1 isoform X1"
                     /calculated_mol_wt=20576
     Region          84..165
                     /region_name="Ets"
                     /note="Ets-domain; pfam00178"
                     /db_xref="CDD:459700"
     CDS             1..183
                     /gene="SPI1"
                     /gene_synonym="AGM10; OF; PU.1; SFPI1; SPI-1; SPI-A"
                     /coded_by="XM_054369739.1:325..876"
                     /db_xref="GeneID:6688"
                     /db_xref="HGNC:HGNC:11241"
                     /db_xref="MIM:165170"
ORIGIN      
        1 meleqmhvld tpmvpphpsl ghqvsylprm clqypslspa qpssdeeege rqspplevsd
       61 geadglepgp gllpgetgsk kkirlyqfll dllrsgdmkd siwwvdkdkg tfqfsskhke
      121 alahrwgiqk gnrkkmtyqk maralrnygk tgevkkvkkk ltyqfsgevl grgglaerrh
      181 pph
//
LOCUS       XP_054225715            2390 aa            linear   PRI 05-AUG-2025
DEFINITION  spectrin beta chain, non-erythrocytic 2 isoform X1 [Homo sapiens].
ACCESSION   XP_054225715
VERSION     XP_054225715.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369740.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2390
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2390
                     /product="spectrin beta chain, non-erythrocytic 2 isoform
                     X1"
                     /calculated_mol_wt=271165
     Region          43..159
                     /region_name="CH_SPTB-like_rpt1"
                     /note="first calponin homology (CH) domain found in the
                     beta-I spectrin-like subfamily; cd21246"
                     /db_xref="CDD:409095"
     Site            order(44,47..48,51..52,55..56,59,113,116..117,120,127,
                     132..140,147..148,150..151,154..155,158..159)
                     /site_type="other"
                     /note="actin binding site [polypeptide binding]"
                     /db_xref="CDD:409095"
     Region          173..291
                     /region_name="CH_SPTBN2_rpt2"
                     /note="second calponin homology (CH) domain found in
                     spectrin beta chain, non-erythrocytic 2 (SPTBN2) and
                     similar proteins; cd21321"
                     /db_xref="CDD:409170"
     Site            order(178,182,232,234..235,238,245,250..258,267..268,
                     270..271,274..275,278)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409170"
     Region          305..414
                     /region_name="Spectrin"
                     /note="Spectrin repeat; pfam00435"
                     /db_xref="CDD:395348"
     Site            416..421
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          429..522
                     /region_name="Spectrin"
                     /note="Spectrin repeat; pfam00435"
                     /db_xref="CDD:395348"
     Region          534..746
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            640..645
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          749..958
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            851..856
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          961..1172
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1064..1069
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1174..1383
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1277..1282
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1384..1588
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1487..1492
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1589..1801
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1693..1698
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1802..2010
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1906..1911
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          2018..>2075
                     /region_name="SPEC"
                     /note="Spectrin repeats; smart00150"
                     /db_xref="CDD:197544"
     Region          <2097..>2241
                     /region_name="dnaA"
                     /note="chromosomal replication initiator protein DnaA;
                     cl42516"
                     /db_xref="CDD:455861"
     Region          2221..2324
                     /region_name="PH_beta_spectrin"
                     /note="Beta-spectrin pleckstrin homology (PH) domain;
                     cd10571"
                     /db_xref="CDD:269975"
     Site            order(2228,2241..2243,2289)
                     /site_type="other"
                     /note="non-cannonical phosphoinositide binding site
                     [chemical binding]"
                     /db_xref="CDD:269975"
     CDS             1..2390
                     /gene="SPTBN2"
                     /gene_synonym="GTRAP41; SCA5; SCAR14"
                     /coded_by="XM_054369740.1:457..7629"
                     /db_xref="GeneID:6712"
                     /db_xref="HGNC:HGNC:11276"
                     /db_xref="MIM:604985"
ORIGIN      
        1 msstlsptdf dsleiqgqys dinnrwdlpd sdwdndsssa rlfersrika ladereavqk
       61 ktftkwvnsh larvtcrvgd lysdlrdgrn llrllevlsg eilpkptkgr mrihclenvd
      121 kalqflkeqk vhlenmgshd ivdgnhrltl glvwtiilrf qiqdisvete dnkekksakd
      181 alllwcqmkt agypnvnvhn fttswrdgla fnaivhkhrp dlldfeslkk cnahynlqna
      241 fnlaekelgl tklldpedvn vdqpdeksii tyvatyyhyf skmkalaveg krigkvldha
      301 meaerlveky eslasellqw ieqtivtlnd rqlanslsgv qnqlqsfnsy rtvekppkft
      361 ekgnlevllf tiqsklrann qkvytpregr lisdinkawe rlekaehere lalrtelirq
      421 ekleqlaarf drkaamretw lsenqrlvsq dnfglelaav eaavrkheai etdivaysgr
      481 vqavdavaae laaeryhdik riaarqhnva rlwdflrqmv aarrerllln lelqkvfqdl
      541 lylmdwmeem kgrlqsqdlg rhlagvedll qlhelveadi avqaervrav sasalrfcnp
      601 gkeyrpcdpq lvservakle qsyealcela aarrarlees rrlwrflwev geaeawvreq
      661 qhllasadtg rdltgalrll nkhtalrgem sgrlgplklt leqgqqlvae ghpgasqasa
      721 raaelqaqwe rlealaeera qrlaqaasly qfqadandme awlvdalrlv sspelghdef
      781 stqalarqhr aleeeirshr ptldalreqa aalpptlsrt pevqgrvptl erhyeelqar
      841 ageraralea alalytmlse agacglwvee keqwlnglal perledlevv qqrfetlepe
      901 mntlaaqita vndiaeqllk anppgkdriv ntqeqlnhrw qqfrrladgk kaaltsalsi
      961 qnyhlectet qawmrektkv iestqglgnd lagvlalqrk lagterdlea iaarvgeltr
     1021 eanalaaghp aqavainarl revqtgwedl ratmrrrees lgearrlqdf lrslddfqaw
     1081 lgrtqtavas eegpatlpea eallaqhaal rgeveraqse ysrlralgee vtrdqadpqc
     1141 lflrqrleal gtgweelgrm wesrqgrlaq ahgfqgflrd arqaegvlss qeyvlshtem
     1201 pgtlqaadaa ikkledfmst mdangerihg lleagrqlvs egnihadkir ekadsierrh
     1261 kknqdaaqqf lgrlrdnreq qhflqdchel klwidekmlt aqdvsydear nlhtkwqkhq
     1321 afmaelaank dwldkvdkeg reltlekpel kalvseklrd lhrrwdelet ttqakarslf
     1381 danraelfaq sccaleswle slqaqlhsdd ygkdltsvni llkkqqmlew emavrekeve
     1441 aiqaqakala qedqgageve rtsraveekf ralcqpmrer crrlqasreq hqfhrdvede
     1501 ilwvterlpm assmehgkdl psvqllmkkn qtlqkeiqgh epriadlrer qralgaaaag
     1561 pelaelqemw krlghelelr gkrledalra qqfyrdaaea eawmgeqelh mmgqekakde
     1621 lsaqaevkkh qvleqalady aqtihqlaas sqdmidhehp estrisirqa qvdklyaglk
     1681 elagerrerl qehlrlcqlr relddleqwi qerevvaash elgqdyehvt mlrdkfrefs
     1741 rdtstigqer vdsanalang liagghaara tvaewkdsln eawadllell dtrgqvlaaa
     1801 yelqrflhga rqalarvqhk qqqlpdgtgr dlnaaealqr rhcayehdiq alspqvqqvq
     1861 ddghrlqkay agdkaeeigr hmqavaeawa qlqgssaarr qllldttdkf rffkavrelm
     1921 lwmdevnlqm daqerprdvs sadlviknqq gikaeieara drfsscidmg kellarshya
     1981 aeeiseklsq lqarrqetae kwqekmdwlq lvlevlvfgr dagmaeawlc sqeplvrsae
     2041 lgctvdeves likrheafqk savaweerfc alekltalee rekerkrkre eeerrkqppa
     2101 peptasvppg dlvggqtasd ttwdgtqprp ppstqapsvn gvctdgepsq pllgqqrleh
     2161 ssfpegpgpg sgdeangprg erqtrtrgpa psampqsrst esahaatlpp rgpepsaqeq
     2221 megmlcrkqe meafgkkaan rswqnvycvl rrgslgfykd akaasagvpy hgevpvslar
     2281 aqgsvafdyr krkhvfklgl qdgkeylfqa kdeaemsswl rvvnaaiata ssasgepeep
     2341 vvpsttrgmt ramtmppvsp vgaegpvvlr skdgrerere krfsffkknk
//
LOCUS       XP_054225716            2390 aa            linear   PRI 05-AUG-2025
DEFINITION  spectrin beta chain, non-erythrocytic 2 isoform X1 [Homo sapiens].
ACCESSION   XP_054225716
VERSION     XP_054225716.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369741.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2390
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2390
                     /product="spectrin beta chain, non-erythrocytic 2 isoform
                     X1"
                     /calculated_mol_wt=271165
     Region          43..159
                     /region_name="CH_SPTB-like_rpt1"
                     /note="first calponin homology (CH) domain found in the
                     beta-I spectrin-like subfamily; cd21246"
                     /db_xref="CDD:409095"
     Site            order(44,47..48,51..52,55..56,59,113,116..117,120,127,
                     132..140,147..148,150..151,154..155,158..159)
                     /site_type="other"
                     /note="actin binding site [polypeptide binding]"
                     /db_xref="CDD:409095"
     Region          173..291
                     /region_name="CH_SPTBN2_rpt2"
                     /note="second calponin homology (CH) domain found in
                     spectrin beta chain, non-erythrocytic 2 (SPTBN2) and
                     similar proteins; cd21321"
                     /db_xref="CDD:409170"
     Site            order(178,182,232,234..235,238,245,250..258,267..268,
                     270..271,274..275,278)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409170"
     Region          305..414
                     /region_name="Spectrin"
                     /note="Spectrin repeat; pfam00435"
                     /db_xref="CDD:395348"
     Site            416..421
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          429..522
                     /region_name="Spectrin"
                     /note="Spectrin repeat; pfam00435"
                     /db_xref="CDD:395348"
     Region          534..746
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            640..645
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          749..958
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            851..856
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          961..1172
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1064..1069
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1174..1383
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1277..1282
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1384..1588
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1487..1492
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1589..1801
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1693..1698
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1802..2010
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1906..1911
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          2018..>2075
                     /region_name="SPEC"
                     /note="Spectrin repeats; smart00150"
                     /db_xref="CDD:197544"
     Region          <2097..>2241
                     /region_name="dnaA"
                     /note="chromosomal replication initiator protein DnaA;
                     cl42516"
                     /db_xref="CDD:455861"
     Region          2221..2324
                     /region_name="PH_beta_spectrin"
                     /note="Beta-spectrin pleckstrin homology (PH) domain;
                     cd10571"
                     /db_xref="CDD:269975"
     Site            order(2228,2241..2243,2289)
                     /site_type="other"
                     /note="non-cannonical phosphoinositide binding site
                     [chemical binding]"
                     /db_xref="CDD:269975"
     CDS             1..2390
                     /gene="SPTBN2"
                     /gene_synonym="GTRAP41; SCA5; SCAR14"
                     /coded_by="XM_054369741.1:271..7443"
                     /db_xref="GeneID:6712"
                     /db_xref="HGNC:HGNC:11276"
                     /db_xref="MIM:604985"
ORIGIN      
        1 msstlsptdf dsleiqgqys dinnrwdlpd sdwdndsssa rlfersrika ladereavqk
       61 ktftkwvnsh larvtcrvgd lysdlrdgrn llrllevlsg eilpkptkgr mrihclenvd
      121 kalqflkeqk vhlenmgshd ivdgnhrltl glvwtiilrf qiqdisvete dnkekksakd
      181 alllwcqmkt agypnvnvhn fttswrdgla fnaivhkhrp dlldfeslkk cnahynlqna
      241 fnlaekelgl tklldpedvn vdqpdeksii tyvatyyhyf skmkalaveg krigkvldha
      301 meaerlveky eslasellqw ieqtivtlnd rqlanslsgv qnqlqsfnsy rtvekppkft
      361 ekgnlevllf tiqsklrann qkvytpregr lisdinkawe rlekaehere lalrtelirq
      421 ekleqlaarf drkaamretw lsenqrlvsq dnfglelaav eaavrkheai etdivaysgr
      481 vqavdavaae laaeryhdik riaarqhnva rlwdflrqmv aarrerllln lelqkvfqdl
      541 lylmdwmeem kgrlqsqdlg rhlagvedll qlhelveadi avqaervrav sasalrfcnp
      601 gkeyrpcdpq lvservakle qsyealcela aarrarlees rrlwrflwev geaeawvreq
      661 qhllasadtg rdltgalrll nkhtalrgem sgrlgplklt leqgqqlvae ghpgasqasa
      721 raaelqaqwe rlealaeera qrlaqaasly qfqadandme awlvdalrlv sspelghdef
      781 stqalarqhr aleeeirshr ptldalreqa aalpptlsrt pevqgrvptl erhyeelqar
      841 ageraralea alalytmlse agacglwvee keqwlnglal perledlevv qqrfetlepe
      901 mntlaaqita vndiaeqllk anppgkdriv ntqeqlnhrw qqfrrladgk kaaltsalsi
      961 qnyhlectet qawmrektkv iestqglgnd lagvlalqrk lagterdlea iaarvgeltr
     1021 eanalaaghp aqavainarl revqtgwedl ratmrrrees lgearrlqdf lrslddfqaw
     1081 lgrtqtavas eegpatlpea eallaqhaal rgeveraqse ysrlralgee vtrdqadpqc
     1141 lflrqrleal gtgweelgrm wesrqgrlaq ahgfqgflrd arqaegvlss qeyvlshtem
     1201 pgtlqaadaa ikkledfmst mdangerihg lleagrqlvs egnihadkir ekadsierrh
     1261 kknqdaaqqf lgrlrdnreq qhflqdchel klwidekmlt aqdvsydear nlhtkwqkhq
     1321 afmaelaank dwldkvdkeg reltlekpel kalvseklrd lhrrwdelet ttqakarslf
     1381 danraelfaq sccaleswle slqaqlhsdd ygkdltsvni llkkqqmlew emavrekeve
     1441 aiqaqakala qedqgageve rtsraveekf ralcqpmrer crrlqasreq hqfhrdvede
     1501 ilwvterlpm assmehgkdl psvqllmkkn qtlqkeiqgh epriadlrer qralgaaaag
     1561 pelaelqemw krlghelelr gkrledalra qqfyrdaaea eawmgeqelh mmgqekakde
     1621 lsaqaevkkh qvleqalady aqtihqlaas sqdmidhehp estrisirqa qvdklyaglk
     1681 elagerrerl qehlrlcqlr relddleqwi qerevvaash elgqdyehvt mlrdkfrefs
     1741 rdtstigqer vdsanalang liagghaara tvaewkdsln eawadllell dtrgqvlaaa
     1801 yelqrflhga rqalarvqhk qqqlpdgtgr dlnaaealqr rhcayehdiq alspqvqqvq
     1861 ddghrlqkay agdkaeeigr hmqavaeawa qlqgssaarr qllldttdkf rffkavrelm
     1921 lwmdevnlqm daqerprdvs sadlviknqq gikaeieara drfsscidmg kellarshya
     1981 aeeiseklsq lqarrqetae kwqekmdwlq lvlevlvfgr dagmaeawlc sqeplvrsae
     2041 lgctvdeves likrheafqk savaweerfc alekltalee rekerkrkre eeerrkqppa
     2101 peptasvppg dlvggqtasd ttwdgtqprp ppstqapsvn gvctdgepsq pllgqqrleh
     2161 ssfpegpgpg sgdeangprg erqtrtrgpa psampqsrst esahaatlpp rgpepsaqeq
     2221 megmlcrkqe meafgkkaan rswqnvycvl rrgslgfykd akaasagvpy hgevpvslar
     2281 aqgsvafdyr krkhvfklgl qdgkeylfqa kdeaemsswl rvvnaaiata ssasgepeep
     2341 vvpsttrgmt ramtmppvsp vgaegpvvlr skdgrerere krfsffkknk
//
LOCUS       XP_054225717            2390 aa            linear   PRI 05-AUG-2025
DEFINITION  spectrin beta chain, non-erythrocytic 2 isoform X1 [Homo sapiens].
ACCESSION   XP_054225717
VERSION     XP_054225717.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369742.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2390
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2390
                     /product="spectrin beta chain, non-erythrocytic 2 isoform
                     X1"
                     /calculated_mol_wt=271165
     Region          43..159
                     /region_name="CH_SPTB-like_rpt1"
                     /note="first calponin homology (CH) domain found in the
                     beta-I spectrin-like subfamily; cd21246"
                     /db_xref="CDD:409095"
     Site            order(44,47..48,51..52,55..56,59,113,116..117,120,127,
                     132..140,147..148,150..151,154..155,158..159)
                     /site_type="other"
                     /note="actin binding site [polypeptide binding]"
                     /db_xref="CDD:409095"
     Region          173..291
                     /region_name="CH_SPTBN2_rpt2"
                     /note="second calponin homology (CH) domain found in
                     spectrin beta chain, non-erythrocytic 2 (SPTBN2) and
                     similar proteins; cd21321"
                     /db_xref="CDD:409170"
     Site            order(178,182,232,234..235,238,245,250..258,267..268,
                     270..271,274..275,278)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409170"
     Region          305..414
                     /region_name="Spectrin"
                     /note="Spectrin repeat; pfam00435"
                     /db_xref="CDD:395348"
     Site            416..421
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          429..522
                     /region_name="Spectrin"
                     /note="Spectrin repeat; pfam00435"
                     /db_xref="CDD:395348"
     Region          534..746
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            640..645
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          749..958
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            851..856
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          961..1172
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1064..1069
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1174..1383
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1277..1282
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1384..1588
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1487..1492
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1589..1801
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1693..1698
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1802..2010
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1906..1911
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          2018..>2075
                     /region_name="SPEC"
                     /note="Spectrin repeats; smart00150"
                     /db_xref="CDD:197544"
     Region          <2097..>2241
                     /region_name="dnaA"
                     /note="chromosomal replication initiator protein DnaA;
                     cl42516"
                     /db_xref="CDD:455861"
     Region          2221..2324
                     /region_name="PH_beta_spectrin"
                     /note="Beta-spectrin pleckstrin homology (PH) domain;
                     cd10571"
                     /db_xref="CDD:269975"
     Site            order(2228,2241..2243,2289)
                     /site_type="other"
                     /note="non-cannonical phosphoinositide binding site
                     [chemical binding]"
                     /db_xref="CDD:269975"
     CDS             1..2390
                     /gene="SPTBN2"
                     /gene_synonym="GTRAP41; SCA5; SCAR14"
                     /coded_by="XM_054369742.1:2013..9185"
                     /db_xref="GeneID:6712"
                     /db_xref="HGNC:HGNC:11276"
                     /db_xref="MIM:604985"
ORIGIN      
        1 msstlsptdf dsleiqgqys dinnrwdlpd sdwdndsssa rlfersrika ladereavqk
       61 ktftkwvnsh larvtcrvgd lysdlrdgrn llrllevlsg eilpkptkgr mrihclenvd
      121 kalqflkeqk vhlenmgshd ivdgnhrltl glvwtiilrf qiqdisvete dnkekksakd
      181 alllwcqmkt agypnvnvhn fttswrdgla fnaivhkhrp dlldfeslkk cnahynlqna
      241 fnlaekelgl tklldpedvn vdqpdeksii tyvatyyhyf skmkalaveg krigkvldha
      301 meaerlveky eslasellqw ieqtivtlnd rqlanslsgv qnqlqsfnsy rtvekppkft
      361 ekgnlevllf tiqsklrann qkvytpregr lisdinkawe rlekaehere lalrtelirq
      421 ekleqlaarf drkaamretw lsenqrlvsq dnfglelaav eaavrkheai etdivaysgr
      481 vqavdavaae laaeryhdik riaarqhnva rlwdflrqmv aarrerllln lelqkvfqdl
      541 lylmdwmeem kgrlqsqdlg rhlagvedll qlhelveadi avqaervrav sasalrfcnp
      601 gkeyrpcdpq lvservakle qsyealcela aarrarlees rrlwrflwev geaeawvreq
      661 qhllasadtg rdltgalrll nkhtalrgem sgrlgplklt leqgqqlvae ghpgasqasa
      721 raaelqaqwe rlealaeera qrlaqaasly qfqadandme awlvdalrlv sspelghdef
      781 stqalarqhr aleeeirshr ptldalreqa aalpptlsrt pevqgrvptl erhyeelqar
      841 ageraralea alalytmlse agacglwvee keqwlnglal perledlevv qqrfetlepe
      901 mntlaaqita vndiaeqllk anppgkdriv ntqeqlnhrw qqfrrladgk kaaltsalsi
      961 qnyhlectet qawmrektkv iestqglgnd lagvlalqrk lagterdlea iaarvgeltr
     1021 eanalaaghp aqavainarl revqtgwedl ratmrrrees lgearrlqdf lrslddfqaw
     1081 lgrtqtavas eegpatlpea eallaqhaal rgeveraqse ysrlralgee vtrdqadpqc
     1141 lflrqrleal gtgweelgrm wesrqgrlaq ahgfqgflrd arqaegvlss qeyvlshtem
     1201 pgtlqaadaa ikkledfmst mdangerihg lleagrqlvs egnihadkir ekadsierrh
     1261 kknqdaaqqf lgrlrdnreq qhflqdchel klwidekmlt aqdvsydear nlhtkwqkhq
     1321 afmaelaank dwldkvdkeg reltlekpel kalvseklrd lhrrwdelet ttqakarslf
     1381 danraelfaq sccaleswle slqaqlhsdd ygkdltsvni llkkqqmlew emavrekeve
     1441 aiqaqakala qedqgageve rtsraveekf ralcqpmrer crrlqasreq hqfhrdvede
     1501 ilwvterlpm assmehgkdl psvqllmkkn qtlqkeiqgh epriadlrer qralgaaaag
     1561 pelaelqemw krlghelelr gkrledalra qqfyrdaaea eawmgeqelh mmgqekakde
     1621 lsaqaevkkh qvleqalady aqtihqlaas sqdmidhehp estrisirqa qvdklyaglk
     1681 elagerrerl qehlrlcqlr relddleqwi qerevvaash elgqdyehvt mlrdkfrefs
     1741 rdtstigqer vdsanalang liagghaara tvaewkdsln eawadllell dtrgqvlaaa
     1801 yelqrflhga rqalarvqhk qqqlpdgtgr dlnaaealqr rhcayehdiq alspqvqqvq
     1861 ddghrlqkay agdkaeeigr hmqavaeawa qlqgssaarr qllldttdkf rffkavrelm
     1921 lwmdevnlqm daqerprdvs sadlviknqq gikaeieara drfsscidmg kellarshya
     1981 aeeiseklsq lqarrqetae kwqekmdwlq lvlevlvfgr dagmaeawlc sqeplvrsae
     2041 lgctvdeves likrheafqk savaweerfc alekltalee rekerkrkre eeerrkqppa
     2101 peptasvppg dlvggqtasd ttwdgtqprp ppstqapsvn gvctdgepsq pllgqqrleh
     2161 ssfpegpgpg sgdeangprg erqtrtrgpa psampqsrst esahaatlpp rgpepsaqeq
     2221 megmlcrkqe meafgkkaan rswqnvycvl rrgslgfykd akaasagvpy hgevpvslar
     2281 aqgsvafdyr krkhvfklgl qdgkeylfqa kdeaemsswl rvvnaaiata ssasgepeep
     2341 vvpsttrgmt ramtmppvsp vgaegpvvlr skdgrerere krfsffkknk
//
LOCUS       XP_054225719            2390 aa            linear   PRI 05-AUG-2025
DEFINITION  spectrin beta chain, non-erythrocytic 2 isoform X1 [Homo sapiens].
ACCESSION   XP_054225719
VERSION     XP_054225719.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369744.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2390
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2390
                     /product="spectrin beta chain, non-erythrocytic 2 isoform
                     X1"
                     /calculated_mol_wt=271165
     Region          43..159
                     /region_name="CH_SPTB-like_rpt1"
                     /note="first calponin homology (CH) domain found in the
                     beta-I spectrin-like subfamily; cd21246"
                     /db_xref="CDD:409095"
     Site            order(44,47..48,51..52,55..56,59,113,116..117,120,127,
                     132..140,147..148,150..151,154..155,158..159)
                     /site_type="other"
                     /note="actin binding site [polypeptide binding]"
                     /db_xref="CDD:409095"
     Region          173..291
                     /region_name="CH_SPTBN2_rpt2"
                     /note="second calponin homology (CH) domain found in
                     spectrin beta chain, non-erythrocytic 2 (SPTBN2) and
                     similar proteins; cd21321"
                     /db_xref="CDD:409170"
     Site            order(178,182,232,234..235,238,245,250..258,267..268,
                     270..271,274..275,278)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409170"
     Region          305..414
                     /region_name="Spectrin"
                     /note="Spectrin repeat; pfam00435"
                     /db_xref="CDD:395348"
     Site            416..421
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          429..522
                     /region_name="Spectrin"
                     /note="Spectrin repeat; pfam00435"
                     /db_xref="CDD:395348"
     Region          534..746
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            640..645
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          749..958
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            851..856
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          961..1172
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1064..1069
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1174..1383
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1277..1282
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1384..1588
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1487..1492
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1589..1801
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1693..1698
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1802..2010
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1906..1911
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          2018..>2075
                     /region_name="SPEC"
                     /note="Spectrin repeats; smart00150"
                     /db_xref="CDD:197544"
     Region          <2097..>2241
                     /region_name="dnaA"
                     /note="chromosomal replication initiator protein DnaA;
                     cl42516"
                     /db_xref="CDD:455861"
     Region          2221..2324
                     /region_name="PH_beta_spectrin"
                     /note="Beta-spectrin pleckstrin homology (PH) domain;
                     cd10571"
                     /db_xref="CDD:269975"
     Site            order(2228,2241..2243,2289)
                     /site_type="other"
                     /note="non-cannonical phosphoinositide binding site
                     [chemical binding]"
                     /db_xref="CDD:269975"
     CDS             1..2390
                     /gene="SPTBN2"
                     /gene_synonym="GTRAP41; SCA5; SCAR14"
                     /coded_by="XM_054369744.1:549..7721"
                     /db_xref="GeneID:6712"
                     /db_xref="HGNC:HGNC:11276"
                     /db_xref="MIM:604985"
ORIGIN      
        1 msstlsptdf dsleiqgqys dinnrwdlpd sdwdndsssa rlfersrika ladereavqk
       61 ktftkwvnsh larvtcrvgd lysdlrdgrn llrllevlsg eilpkptkgr mrihclenvd
      121 kalqflkeqk vhlenmgshd ivdgnhrltl glvwtiilrf qiqdisvete dnkekksakd
      181 alllwcqmkt agypnvnvhn fttswrdgla fnaivhkhrp dlldfeslkk cnahynlqna
      241 fnlaekelgl tklldpedvn vdqpdeksii tyvatyyhyf skmkalaveg krigkvldha
      301 meaerlveky eslasellqw ieqtivtlnd rqlanslsgv qnqlqsfnsy rtvekppkft
      361 ekgnlevllf tiqsklrann qkvytpregr lisdinkawe rlekaehere lalrtelirq
      421 ekleqlaarf drkaamretw lsenqrlvsq dnfglelaav eaavrkheai etdivaysgr
      481 vqavdavaae laaeryhdik riaarqhnva rlwdflrqmv aarrerllln lelqkvfqdl
      541 lylmdwmeem kgrlqsqdlg rhlagvedll qlhelveadi avqaervrav sasalrfcnp
      601 gkeyrpcdpq lvservakle qsyealcela aarrarlees rrlwrflwev geaeawvreq
      661 qhllasadtg rdltgalrll nkhtalrgem sgrlgplklt leqgqqlvae ghpgasqasa
      721 raaelqaqwe rlealaeera qrlaqaasly qfqadandme awlvdalrlv sspelghdef
      781 stqalarqhr aleeeirshr ptldalreqa aalpptlsrt pevqgrvptl erhyeelqar
      841 ageraralea alalytmlse agacglwvee keqwlnglal perledlevv qqrfetlepe
      901 mntlaaqita vndiaeqllk anppgkdriv ntqeqlnhrw qqfrrladgk kaaltsalsi
      961 qnyhlectet qawmrektkv iestqglgnd lagvlalqrk lagterdlea iaarvgeltr
     1021 eanalaaghp aqavainarl revqtgwedl ratmrrrees lgearrlqdf lrslddfqaw
     1081 lgrtqtavas eegpatlpea eallaqhaal rgeveraqse ysrlralgee vtrdqadpqc
     1141 lflrqrleal gtgweelgrm wesrqgrlaq ahgfqgflrd arqaegvlss qeyvlshtem
     1201 pgtlqaadaa ikkledfmst mdangerihg lleagrqlvs egnihadkir ekadsierrh
     1261 kknqdaaqqf lgrlrdnreq qhflqdchel klwidekmlt aqdvsydear nlhtkwqkhq
     1321 afmaelaank dwldkvdkeg reltlekpel kalvseklrd lhrrwdelet ttqakarslf
     1381 danraelfaq sccaleswle slqaqlhsdd ygkdltsvni llkkqqmlew emavrekeve
     1441 aiqaqakala qedqgageve rtsraveekf ralcqpmrer crrlqasreq hqfhrdvede
     1501 ilwvterlpm assmehgkdl psvqllmkkn qtlqkeiqgh epriadlrer qralgaaaag
     1561 pelaelqemw krlghelelr gkrledalra qqfyrdaaea eawmgeqelh mmgqekakde
     1621 lsaqaevkkh qvleqalady aqtihqlaas sqdmidhehp estrisirqa qvdklyaglk
     1681 elagerrerl qehlrlcqlr relddleqwi qerevvaash elgqdyehvt mlrdkfrefs
     1741 rdtstigqer vdsanalang liagghaara tvaewkdsln eawadllell dtrgqvlaaa
     1801 yelqrflhga rqalarvqhk qqqlpdgtgr dlnaaealqr rhcayehdiq alspqvqqvq
     1861 ddghrlqkay agdkaeeigr hmqavaeawa qlqgssaarr qllldttdkf rffkavrelm
     1921 lwmdevnlqm daqerprdvs sadlviknqq gikaeieara drfsscidmg kellarshya
     1981 aeeiseklsq lqarrqetae kwqekmdwlq lvlevlvfgr dagmaeawlc sqeplvrsae
     2041 lgctvdeves likrheafqk savaweerfc alekltalee rekerkrkre eeerrkqppa
     2101 peptasvppg dlvggqtasd ttwdgtqprp ppstqapsvn gvctdgepsq pllgqqrleh
     2161 ssfpegpgpg sgdeangprg erqtrtrgpa psampqsrst esahaatlpp rgpepsaqeq
     2221 megmlcrkqe meafgkkaan rswqnvycvl rrgslgfykd akaasagvpy hgevpvslar
     2281 aqgsvafdyr krkhvfklgl qdgkeylfqa kdeaemsswl rvvnaaiata ssasgepeep
     2341 vvpsttrgmt ramtmppvsp vgaegpvvlr skdgrerere krfsffkknk
//
LOCUS       XP_054225720            2390 aa            linear   PRI 05-AUG-2025
DEFINITION  spectrin beta chain, non-erythrocytic 2 isoform X1 [Homo sapiens].
ACCESSION   XP_054225720
VERSION     XP_054225720.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369745.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2390
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2390
                     /product="spectrin beta chain, non-erythrocytic 2 isoform
                     X1"
                     /calculated_mol_wt=271165
     Region          43..159
                     /region_name="CH_SPTB-like_rpt1"
                     /note="first calponin homology (CH) domain found in the
                     beta-I spectrin-like subfamily; cd21246"
                     /db_xref="CDD:409095"
     Site            order(44,47..48,51..52,55..56,59,113,116..117,120,127,
                     132..140,147..148,150..151,154..155,158..159)
                     /site_type="other"
                     /note="actin binding site [polypeptide binding]"
                     /db_xref="CDD:409095"
     Region          173..291
                     /region_name="CH_SPTBN2_rpt2"
                     /note="second calponin homology (CH) domain found in
                     spectrin beta chain, non-erythrocytic 2 (SPTBN2) and
                     similar proteins; cd21321"
                     /db_xref="CDD:409170"
     Site            order(178,182,232,234..235,238,245,250..258,267..268,
                     270..271,274..275,278)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409170"
     Region          305..414
                     /region_name="Spectrin"
                     /note="Spectrin repeat; pfam00435"
                     /db_xref="CDD:395348"
     Site            416..421
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          429..522
                     /region_name="Spectrin"
                     /note="Spectrin repeat; pfam00435"
                     /db_xref="CDD:395348"
     Region          534..746
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            640..645
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          749..958
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            851..856
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          961..1172
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1064..1069
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1174..1383
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1277..1282
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1384..1588
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1487..1492
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1589..1801
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1693..1698
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1802..2010
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1906..1911
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          2018..>2075
                     /region_name="SPEC"
                     /note="Spectrin repeats; smart00150"
                     /db_xref="CDD:197544"
     Region          <2097..>2241
                     /region_name="dnaA"
                     /note="chromosomal replication initiator protein DnaA;
                     cl42516"
                     /db_xref="CDD:455861"
     Region          2221..2324
                     /region_name="PH_beta_spectrin"
                     /note="Beta-spectrin pleckstrin homology (PH) domain;
                     cd10571"
                     /db_xref="CDD:269975"
     Site            order(2228,2241..2243,2289)
                     /site_type="other"
                     /note="non-cannonical phosphoinositide binding site
                     [chemical binding]"
                     /db_xref="CDD:269975"
     CDS             1..2390
                     /gene="SPTBN2"
                     /gene_synonym="GTRAP41; SCA5; SCAR14"
                     /coded_by="XM_054369745.1:682..7854"
                     /db_xref="GeneID:6712"
                     /db_xref="HGNC:HGNC:11276"
                     /db_xref="MIM:604985"
ORIGIN      
        1 msstlsptdf dsleiqgqys dinnrwdlpd sdwdndsssa rlfersrika ladereavqk
       61 ktftkwvnsh larvtcrvgd lysdlrdgrn llrllevlsg eilpkptkgr mrihclenvd
      121 kalqflkeqk vhlenmgshd ivdgnhrltl glvwtiilrf qiqdisvete dnkekksakd
      181 alllwcqmkt agypnvnvhn fttswrdgla fnaivhkhrp dlldfeslkk cnahynlqna
      241 fnlaekelgl tklldpedvn vdqpdeksii tyvatyyhyf skmkalaveg krigkvldha
      301 meaerlveky eslasellqw ieqtivtlnd rqlanslsgv qnqlqsfnsy rtvekppkft
      361 ekgnlevllf tiqsklrann qkvytpregr lisdinkawe rlekaehere lalrtelirq
      421 ekleqlaarf drkaamretw lsenqrlvsq dnfglelaav eaavrkheai etdivaysgr
      481 vqavdavaae laaeryhdik riaarqhnva rlwdflrqmv aarrerllln lelqkvfqdl
      541 lylmdwmeem kgrlqsqdlg rhlagvedll qlhelveadi avqaervrav sasalrfcnp
      601 gkeyrpcdpq lvservakle qsyealcela aarrarlees rrlwrflwev geaeawvreq
      661 qhllasadtg rdltgalrll nkhtalrgem sgrlgplklt leqgqqlvae ghpgasqasa
      721 raaelqaqwe rlealaeera qrlaqaasly qfqadandme awlvdalrlv sspelghdef
      781 stqalarqhr aleeeirshr ptldalreqa aalpptlsrt pevqgrvptl erhyeelqar
      841 ageraralea alalytmlse agacglwvee keqwlnglal perledlevv qqrfetlepe
      901 mntlaaqita vndiaeqllk anppgkdriv ntqeqlnhrw qqfrrladgk kaaltsalsi
      961 qnyhlectet qawmrektkv iestqglgnd lagvlalqrk lagterdlea iaarvgeltr
     1021 eanalaaghp aqavainarl revqtgwedl ratmrrrees lgearrlqdf lrslddfqaw
     1081 lgrtqtavas eegpatlpea eallaqhaal rgeveraqse ysrlralgee vtrdqadpqc
     1141 lflrqrleal gtgweelgrm wesrqgrlaq ahgfqgflrd arqaegvlss qeyvlshtem
     1201 pgtlqaadaa ikkledfmst mdangerihg lleagrqlvs egnihadkir ekadsierrh
     1261 kknqdaaqqf lgrlrdnreq qhflqdchel klwidekmlt aqdvsydear nlhtkwqkhq
     1321 afmaelaank dwldkvdkeg reltlekpel kalvseklrd lhrrwdelet ttqakarslf
     1381 danraelfaq sccaleswle slqaqlhsdd ygkdltsvni llkkqqmlew emavrekeve
     1441 aiqaqakala qedqgageve rtsraveekf ralcqpmrer crrlqasreq hqfhrdvede
     1501 ilwvterlpm assmehgkdl psvqllmkkn qtlqkeiqgh epriadlrer qralgaaaag
     1561 pelaelqemw krlghelelr gkrledalra qqfyrdaaea eawmgeqelh mmgqekakde
     1621 lsaqaevkkh qvleqalady aqtihqlaas sqdmidhehp estrisirqa qvdklyaglk
     1681 elagerrerl qehlrlcqlr relddleqwi qerevvaash elgqdyehvt mlrdkfrefs
     1741 rdtstigqer vdsanalang liagghaara tvaewkdsln eawadllell dtrgqvlaaa
     1801 yelqrflhga rqalarvqhk qqqlpdgtgr dlnaaealqr rhcayehdiq alspqvqqvq
     1861 ddghrlqkay agdkaeeigr hmqavaeawa qlqgssaarr qllldttdkf rffkavrelm
     1921 lwmdevnlqm daqerprdvs sadlviknqq gikaeieara drfsscidmg kellarshya
     1981 aeeiseklsq lqarrqetae kwqekmdwlq lvlevlvfgr dagmaeawlc sqeplvrsae
     2041 lgctvdeves likrheafqk savaweerfc alekltalee rekerkrkre eeerrkqppa
     2101 peptasvppg dlvggqtasd ttwdgtqprp ppstqapsvn gvctdgepsq pllgqqrleh
     2161 ssfpegpgpg sgdeangprg erqtrtrgpa psampqsrst esahaatlpp rgpepsaqeq
     2221 megmlcrkqe meafgkkaan rswqnvycvl rrgslgfykd akaasagvpy hgevpvslar
     2281 aqgsvafdyr krkhvfklgl qdgkeylfqa kdeaemsswl rvvnaaiata ssasgepeep
     2341 vvpsttrgmt ramtmppvsp vgaegpvvlr skdgrerere krfsffkknk
//
LOCUS       XP_054225721            2390 aa            linear   PRI 05-AUG-2025
DEFINITION  spectrin beta chain, non-erythrocytic 2 isoform X1 [Homo sapiens].
ACCESSION   XP_054225721
VERSION     XP_054225721.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369746.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2390
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2390
                     /product="spectrin beta chain, non-erythrocytic 2 isoform
                     X1"
                     /calculated_mol_wt=271165
     Region          43..159
                     /region_name="CH_SPTB-like_rpt1"
                     /note="first calponin homology (CH) domain found in the
                     beta-I spectrin-like subfamily; cd21246"
                     /db_xref="CDD:409095"
     Site            order(44,47..48,51..52,55..56,59,113,116..117,120,127,
                     132..140,147..148,150..151,154..155,158..159)
                     /site_type="other"
                     /note="actin binding site [polypeptide binding]"
                     /db_xref="CDD:409095"
     Region          173..291
                     /region_name="CH_SPTBN2_rpt2"
                     /note="second calponin homology (CH) domain found in
                     spectrin beta chain, non-erythrocytic 2 (SPTBN2) and
                     similar proteins; cd21321"
                     /db_xref="CDD:409170"
     Site            order(178,182,232,234..235,238,245,250..258,267..268,
                     270..271,274..275,278)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409170"
     Region          305..414
                     /region_name="Spectrin"
                     /note="Spectrin repeat; pfam00435"
                     /db_xref="CDD:395348"
     Site            416..421
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          429..522
                     /region_name="Spectrin"
                     /note="Spectrin repeat; pfam00435"
                     /db_xref="CDD:395348"
     Region          534..746
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            640..645
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          749..958
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            851..856
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          961..1172
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1064..1069
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1174..1383
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1277..1282
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1384..1588
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1487..1492
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1589..1801
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1693..1698
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1802..2010
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1906..1911
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          2018..>2075
                     /region_name="SPEC"
                     /note="Spectrin repeats; smart00150"
                     /db_xref="CDD:197544"
     Region          <2097..>2241
                     /region_name="dnaA"
                     /note="chromosomal replication initiator protein DnaA;
                     cl42516"
                     /db_xref="CDD:455861"
     Region          2221..2324
                     /region_name="PH_beta_spectrin"
                     /note="Beta-spectrin pleckstrin homology (PH) domain;
                     cd10571"
                     /db_xref="CDD:269975"
     Site            order(2228,2241..2243,2289)
                     /site_type="other"
                     /note="non-cannonical phosphoinositide binding site
                     [chemical binding]"
                     /db_xref="CDD:269975"
     CDS             1..2390
                     /gene="SPTBN2"
                     /gene_synonym="GTRAP41; SCA5; SCAR14"
                     /coded_by="XM_054369746.1:366..7538"
                     /db_xref="GeneID:6712"
                     /db_xref="HGNC:HGNC:11276"
                     /db_xref="MIM:604985"
ORIGIN      
        1 msstlsptdf dsleiqgqys dinnrwdlpd sdwdndsssa rlfersrika ladereavqk
       61 ktftkwvnsh larvtcrvgd lysdlrdgrn llrllevlsg eilpkptkgr mrihclenvd
      121 kalqflkeqk vhlenmgshd ivdgnhrltl glvwtiilrf qiqdisvete dnkekksakd
      181 alllwcqmkt agypnvnvhn fttswrdgla fnaivhkhrp dlldfeslkk cnahynlqna
      241 fnlaekelgl tklldpedvn vdqpdeksii tyvatyyhyf skmkalaveg krigkvldha
      301 meaerlveky eslasellqw ieqtivtlnd rqlanslsgv qnqlqsfnsy rtvekppkft
      361 ekgnlevllf tiqsklrann qkvytpregr lisdinkawe rlekaehere lalrtelirq
      421 ekleqlaarf drkaamretw lsenqrlvsq dnfglelaav eaavrkheai etdivaysgr
      481 vqavdavaae laaeryhdik riaarqhnva rlwdflrqmv aarrerllln lelqkvfqdl
      541 lylmdwmeem kgrlqsqdlg rhlagvedll qlhelveadi avqaervrav sasalrfcnp
      601 gkeyrpcdpq lvservakle qsyealcela aarrarlees rrlwrflwev geaeawvreq
      661 qhllasadtg rdltgalrll nkhtalrgem sgrlgplklt leqgqqlvae ghpgasqasa
      721 raaelqaqwe rlealaeera qrlaqaasly qfqadandme awlvdalrlv sspelghdef
      781 stqalarqhr aleeeirshr ptldalreqa aalpptlsrt pevqgrvptl erhyeelqar
      841 ageraralea alalytmlse agacglwvee keqwlnglal perledlevv qqrfetlepe
      901 mntlaaqita vndiaeqllk anppgkdriv ntqeqlnhrw qqfrrladgk kaaltsalsi
      961 qnyhlectet qawmrektkv iestqglgnd lagvlalqrk lagterdlea iaarvgeltr
     1021 eanalaaghp aqavainarl revqtgwedl ratmrrrees lgearrlqdf lrslddfqaw
     1081 lgrtqtavas eegpatlpea eallaqhaal rgeveraqse ysrlralgee vtrdqadpqc
     1141 lflrqrleal gtgweelgrm wesrqgrlaq ahgfqgflrd arqaegvlss qeyvlshtem
     1201 pgtlqaadaa ikkledfmst mdangerihg lleagrqlvs egnihadkir ekadsierrh
     1261 kknqdaaqqf lgrlrdnreq qhflqdchel klwidekmlt aqdvsydear nlhtkwqkhq
     1321 afmaelaank dwldkvdkeg reltlekpel kalvseklrd lhrrwdelet ttqakarslf
     1381 danraelfaq sccaleswle slqaqlhsdd ygkdltsvni llkkqqmlew emavrekeve
     1441 aiqaqakala qedqgageve rtsraveekf ralcqpmrer crrlqasreq hqfhrdvede
     1501 ilwvterlpm assmehgkdl psvqllmkkn qtlqkeiqgh epriadlrer qralgaaaag
     1561 pelaelqemw krlghelelr gkrledalra qqfyrdaaea eawmgeqelh mmgqekakde
     1621 lsaqaevkkh qvleqalady aqtihqlaas sqdmidhehp estrisirqa qvdklyaglk
     1681 elagerrerl qehlrlcqlr relddleqwi qerevvaash elgqdyehvt mlrdkfrefs
     1741 rdtstigqer vdsanalang liagghaara tvaewkdsln eawadllell dtrgqvlaaa
     1801 yelqrflhga rqalarvqhk qqqlpdgtgr dlnaaealqr rhcayehdiq alspqvqqvq
     1861 ddghrlqkay agdkaeeigr hmqavaeawa qlqgssaarr qllldttdkf rffkavrelm
     1921 lwmdevnlqm daqerprdvs sadlviknqq gikaeieara drfsscidmg kellarshya
     1981 aeeiseklsq lqarrqetae kwqekmdwlq lvlevlvfgr dagmaeawlc sqeplvrsae
     2041 lgctvdeves likrheafqk savaweerfc alekltalee rekerkrkre eeerrkqppa
     2101 peptasvppg dlvggqtasd ttwdgtqprp ppstqapsvn gvctdgepsq pllgqqrleh
     2161 ssfpegpgpg sgdeangprg erqtrtrgpa psampqsrst esahaatlpp rgpepsaqeq
     2221 megmlcrkqe meafgkkaan rswqnvycvl rrgslgfykd akaasagvpy hgevpvslar
     2281 aqgsvafdyr krkhvfklgl qdgkeylfqa kdeaemsswl rvvnaaiata ssasgepeep
     2341 vvpsttrgmt ramtmppvsp vgaegpvvlr skdgrerere krfsffkknk
//
LOCUS       XP_054225722            2390 aa            linear   PRI 05-AUG-2025
DEFINITION  spectrin beta chain, non-erythrocytic 2 isoform X1 [Homo sapiens].
ACCESSION   XP_054225722
VERSION     XP_054225722.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369747.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2390
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2390
                     /product="spectrin beta chain, non-erythrocytic 2 isoform
                     X1"
                     /calculated_mol_wt=271165
     Region          43..159
                     /region_name="CH_SPTB-like_rpt1"
                     /note="first calponin homology (CH) domain found in the
                     beta-I spectrin-like subfamily; cd21246"
                     /db_xref="CDD:409095"
     Site            order(44,47..48,51..52,55..56,59,113,116..117,120,127,
                     132..140,147..148,150..151,154..155,158..159)
                     /site_type="other"
                     /note="actin binding site [polypeptide binding]"
                     /db_xref="CDD:409095"
     Region          173..291
                     /region_name="CH_SPTBN2_rpt2"
                     /note="second calponin homology (CH) domain found in
                     spectrin beta chain, non-erythrocytic 2 (SPTBN2) and
                     similar proteins; cd21321"
                     /db_xref="CDD:409170"
     Site            order(178,182,232,234..235,238,245,250..258,267..268,
                     270..271,274..275,278)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409170"
     Region          305..414
                     /region_name="Spectrin"
                     /note="Spectrin repeat; pfam00435"
                     /db_xref="CDD:395348"
     Site            416..421
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          429..522
                     /region_name="Spectrin"
                     /note="Spectrin repeat; pfam00435"
                     /db_xref="CDD:395348"
     Region          534..746
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            640..645
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          749..958
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            851..856
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          961..1172
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1064..1069
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1174..1383
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1277..1282
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1384..1588
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1487..1492
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1589..1801
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1693..1698
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1802..2010
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1906..1911
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          2018..>2075
                     /region_name="SPEC"
                     /note="Spectrin repeats; smart00150"
                     /db_xref="CDD:197544"
     Region          <2097..>2241
                     /region_name="dnaA"
                     /note="chromosomal replication initiator protein DnaA;
                     cl42516"
                     /db_xref="CDD:455861"
     Region          2221..2324
                     /region_name="PH_beta_spectrin"
                     /note="Beta-spectrin pleckstrin homology (PH) domain;
                     cd10571"
                     /db_xref="CDD:269975"
     Site            order(2228,2241..2243,2289)
                     /site_type="other"
                     /note="non-cannonical phosphoinositide binding site
                     [chemical binding]"
                     /db_xref="CDD:269975"
     CDS             1..2390
                     /gene="SPTBN2"
                     /gene_synonym="GTRAP41; SCA5; SCAR14"
                     /coded_by="XM_054369747.1:280..7452"
                     /db_xref="GeneID:6712"
                     /db_xref="HGNC:HGNC:11276"
                     /db_xref="MIM:604985"
ORIGIN      
        1 msstlsptdf dsleiqgqys dinnrwdlpd sdwdndsssa rlfersrika ladereavqk
       61 ktftkwvnsh larvtcrvgd lysdlrdgrn llrllevlsg eilpkptkgr mrihclenvd
      121 kalqflkeqk vhlenmgshd ivdgnhrltl glvwtiilrf qiqdisvete dnkekksakd
      181 alllwcqmkt agypnvnvhn fttswrdgla fnaivhkhrp dlldfeslkk cnahynlqna
      241 fnlaekelgl tklldpedvn vdqpdeksii tyvatyyhyf skmkalaveg krigkvldha
      301 meaerlveky eslasellqw ieqtivtlnd rqlanslsgv qnqlqsfnsy rtvekppkft
      361 ekgnlevllf tiqsklrann qkvytpregr lisdinkawe rlekaehere lalrtelirq
      421 ekleqlaarf drkaamretw lsenqrlvsq dnfglelaav eaavrkheai etdivaysgr
      481 vqavdavaae laaeryhdik riaarqhnva rlwdflrqmv aarrerllln lelqkvfqdl
      541 lylmdwmeem kgrlqsqdlg rhlagvedll qlhelveadi avqaervrav sasalrfcnp
      601 gkeyrpcdpq lvservakle qsyealcela aarrarlees rrlwrflwev geaeawvreq
      661 qhllasadtg rdltgalrll nkhtalrgem sgrlgplklt leqgqqlvae ghpgasqasa
      721 raaelqaqwe rlealaeera qrlaqaasly qfqadandme awlvdalrlv sspelghdef
      781 stqalarqhr aleeeirshr ptldalreqa aalpptlsrt pevqgrvptl erhyeelqar
      841 ageraralea alalytmlse agacglwvee keqwlnglal perledlevv qqrfetlepe
      901 mntlaaqita vndiaeqllk anppgkdriv ntqeqlnhrw qqfrrladgk kaaltsalsi
      961 qnyhlectet qawmrektkv iestqglgnd lagvlalqrk lagterdlea iaarvgeltr
     1021 eanalaaghp aqavainarl revqtgwedl ratmrrrees lgearrlqdf lrslddfqaw
     1081 lgrtqtavas eegpatlpea eallaqhaal rgeveraqse ysrlralgee vtrdqadpqc
     1141 lflrqrleal gtgweelgrm wesrqgrlaq ahgfqgflrd arqaegvlss qeyvlshtem
     1201 pgtlqaadaa ikkledfmst mdangerihg lleagrqlvs egnihadkir ekadsierrh
     1261 kknqdaaqqf lgrlrdnreq qhflqdchel klwidekmlt aqdvsydear nlhtkwqkhq
     1321 afmaelaank dwldkvdkeg reltlekpel kalvseklrd lhrrwdelet ttqakarslf
     1381 danraelfaq sccaleswle slqaqlhsdd ygkdltsvni llkkqqmlew emavrekeve
     1441 aiqaqakala qedqgageve rtsraveekf ralcqpmrer crrlqasreq hqfhrdvede
     1501 ilwvterlpm assmehgkdl psvqllmkkn qtlqkeiqgh epriadlrer qralgaaaag
     1561 pelaelqemw krlghelelr gkrledalra qqfyrdaaea eawmgeqelh mmgqekakde
     1621 lsaqaevkkh qvleqalady aqtihqlaas sqdmidhehp estrisirqa qvdklyaglk
     1681 elagerrerl qehlrlcqlr relddleqwi qerevvaash elgqdyehvt mlrdkfrefs
     1741 rdtstigqer vdsanalang liagghaara tvaewkdsln eawadllell dtrgqvlaaa
     1801 yelqrflhga rqalarvqhk qqqlpdgtgr dlnaaealqr rhcayehdiq alspqvqqvq
     1861 ddghrlqkay agdkaeeigr hmqavaeawa qlqgssaarr qllldttdkf rffkavrelm
     1921 lwmdevnlqm daqerprdvs sadlviknqq gikaeieara drfsscidmg kellarshya
     1981 aeeiseklsq lqarrqetae kwqekmdwlq lvlevlvfgr dagmaeawlc sqeplvrsae
     2041 lgctvdeves likrheafqk savaweerfc alekltalee rekerkrkre eeerrkqppa
     2101 peptasvppg dlvggqtasd ttwdgtqprp ppstqapsvn gvctdgepsq pllgqqrleh
     2161 ssfpegpgpg sgdeangprg erqtrtrgpa psampqsrst esahaatlpp rgpepsaqeq
     2221 megmlcrkqe meafgkkaan rswqnvycvl rrgslgfykd akaasagvpy hgevpvslar
     2281 aqgsvafdyr krkhvfklgl qdgkeylfqa kdeaemsswl rvvnaaiata ssasgepeep
     2341 vvpsttrgmt ramtmppvsp vgaegpvvlr skdgrerere krfsffkknk
//
LOCUS       XP_054225723            2390 aa            linear   PRI 05-AUG-2025
DEFINITION  spectrin beta chain, non-erythrocytic 2 isoform X1 [Homo sapiens].
ACCESSION   XP_054225723
VERSION     XP_054225723.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369748.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2390
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2390
                     /product="spectrin beta chain, non-erythrocytic 2 isoform
                     X1"
                     /calculated_mol_wt=271165
     Region          43..159
                     /region_name="CH_SPTB-like_rpt1"
                     /note="first calponin homology (CH) domain found in the
                     beta-I spectrin-like subfamily; cd21246"
                     /db_xref="CDD:409095"
     Site            order(44,47..48,51..52,55..56,59,113,116..117,120,127,
                     132..140,147..148,150..151,154..155,158..159)
                     /site_type="other"
                     /note="actin binding site [polypeptide binding]"
                     /db_xref="CDD:409095"
     Region          173..291
                     /region_name="CH_SPTBN2_rpt2"
                     /note="second calponin homology (CH) domain found in
                     spectrin beta chain, non-erythrocytic 2 (SPTBN2) and
                     similar proteins; cd21321"
                     /db_xref="CDD:409170"
     Site            order(178,182,232,234..235,238,245,250..258,267..268,
                     270..271,274..275,278)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409170"
     Region          305..414
                     /region_name="Spectrin"
                     /note="Spectrin repeat; pfam00435"
                     /db_xref="CDD:395348"
     Site            416..421
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          429..522
                     /region_name="Spectrin"
                     /note="Spectrin repeat; pfam00435"
                     /db_xref="CDD:395348"
     Region          534..746
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            640..645
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          749..958
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            851..856
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          961..1172
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1064..1069
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1174..1383
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1277..1282
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1384..1588
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1487..1492
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1589..1801
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1693..1698
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1802..2010
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1906..1911
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          2018..>2075
                     /region_name="SPEC"
                     /note="Spectrin repeats; smart00150"
                     /db_xref="CDD:197544"
     Region          <2097..>2241
                     /region_name="dnaA"
                     /note="chromosomal replication initiator protein DnaA;
                     cl42516"
                     /db_xref="CDD:455861"
     Region          2221..2324
                     /region_name="PH_beta_spectrin"
                     /note="Beta-spectrin pleckstrin homology (PH) domain;
                     cd10571"
                     /db_xref="CDD:269975"
     Site            order(2228,2241..2243,2289)
                     /site_type="other"
                     /note="non-cannonical phosphoinositide binding site
                     [chemical binding]"
                     /db_xref="CDD:269975"
     CDS             1..2390
                     /gene="SPTBN2"
                     /gene_synonym="GTRAP41; SCA5; SCAR14"
                     /coded_by="XM_054369748.1:309..7481"
                     /db_xref="GeneID:6712"
                     /db_xref="HGNC:HGNC:11276"
                     /db_xref="MIM:604985"
ORIGIN      
        1 msstlsptdf dsleiqgqys dinnrwdlpd sdwdndsssa rlfersrika ladereavqk
       61 ktftkwvnsh larvtcrvgd lysdlrdgrn llrllevlsg eilpkptkgr mrihclenvd
      121 kalqflkeqk vhlenmgshd ivdgnhrltl glvwtiilrf qiqdisvete dnkekksakd
      181 alllwcqmkt agypnvnvhn fttswrdgla fnaivhkhrp dlldfeslkk cnahynlqna
      241 fnlaekelgl tklldpedvn vdqpdeksii tyvatyyhyf skmkalaveg krigkvldha
      301 meaerlveky eslasellqw ieqtivtlnd rqlanslsgv qnqlqsfnsy rtvekppkft
      361 ekgnlevllf tiqsklrann qkvytpregr lisdinkawe rlekaehere lalrtelirq
      421 ekleqlaarf drkaamretw lsenqrlvsq dnfglelaav eaavrkheai etdivaysgr
      481 vqavdavaae laaeryhdik riaarqhnva rlwdflrqmv aarrerllln lelqkvfqdl
      541 lylmdwmeem kgrlqsqdlg rhlagvedll qlhelveadi avqaervrav sasalrfcnp
      601 gkeyrpcdpq lvservakle qsyealcela aarrarlees rrlwrflwev geaeawvreq
      661 qhllasadtg rdltgalrll nkhtalrgem sgrlgplklt leqgqqlvae ghpgasqasa
      721 raaelqaqwe rlealaeera qrlaqaasly qfqadandme awlvdalrlv sspelghdef
      781 stqalarqhr aleeeirshr ptldalreqa aalpptlsrt pevqgrvptl erhyeelqar
      841 ageraralea alalytmlse agacglwvee keqwlnglal perledlevv qqrfetlepe
      901 mntlaaqita vndiaeqllk anppgkdriv ntqeqlnhrw qqfrrladgk kaaltsalsi
      961 qnyhlectet qawmrektkv iestqglgnd lagvlalqrk lagterdlea iaarvgeltr
     1021 eanalaaghp aqavainarl revqtgwedl ratmrrrees lgearrlqdf lrslddfqaw
     1081 lgrtqtavas eegpatlpea eallaqhaal rgeveraqse ysrlralgee vtrdqadpqc
     1141 lflrqrleal gtgweelgrm wesrqgrlaq ahgfqgflrd arqaegvlss qeyvlshtem
     1201 pgtlqaadaa ikkledfmst mdangerihg lleagrqlvs egnihadkir ekadsierrh
     1261 kknqdaaqqf lgrlrdnreq qhflqdchel klwidekmlt aqdvsydear nlhtkwqkhq
     1321 afmaelaank dwldkvdkeg reltlekpel kalvseklrd lhrrwdelet ttqakarslf
     1381 danraelfaq sccaleswle slqaqlhsdd ygkdltsvni llkkqqmlew emavrekeve
     1441 aiqaqakala qedqgageve rtsraveekf ralcqpmrer crrlqasreq hqfhrdvede
     1501 ilwvterlpm assmehgkdl psvqllmkkn qtlqkeiqgh epriadlrer qralgaaaag
     1561 pelaelqemw krlghelelr gkrledalra qqfyrdaaea eawmgeqelh mmgqekakde
     1621 lsaqaevkkh qvleqalady aqtihqlaas sqdmidhehp estrisirqa qvdklyaglk
     1681 elagerrerl qehlrlcqlr relddleqwi qerevvaash elgqdyehvt mlrdkfrefs
     1741 rdtstigqer vdsanalang liagghaara tvaewkdsln eawadllell dtrgqvlaaa
     1801 yelqrflhga rqalarvqhk qqqlpdgtgr dlnaaealqr rhcayehdiq alspqvqqvq
     1861 ddghrlqkay agdkaeeigr hmqavaeawa qlqgssaarr qllldttdkf rffkavrelm
     1921 lwmdevnlqm daqerprdvs sadlviknqq gikaeieara drfsscidmg kellarshya
     1981 aeeiseklsq lqarrqetae kwqekmdwlq lvlevlvfgr dagmaeawlc sqeplvrsae
     2041 lgctvdeves likrheafqk savaweerfc alekltalee rekerkrkre eeerrkqppa
     2101 peptasvppg dlvggqtasd ttwdgtqprp ppstqapsvn gvctdgepsq pllgqqrleh
     2161 ssfpegpgpg sgdeangprg erqtrtrgpa psampqsrst esahaatlpp rgpepsaqeq
     2221 megmlcrkqe meafgkkaan rswqnvycvl rrgslgfykd akaasagvpy hgevpvslar
     2281 aqgsvafdyr krkhvfklgl qdgkeylfqa kdeaemsswl rvvnaaiata ssasgepeep
     2341 vvpsttrgmt ramtmppvsp vgaegpvvlr skdgrerere krfsffkknk
//
LOCUS       XP_054225724            2390 aa            linear   PRI 05-AUG-2025
DEFINITION  spectrin beta chain, non-erythrocytic 2 isoform X1 [Homo sapiens].
ACCESSION   XP_054225724
VERSION     XP_054225724.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369749.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2390
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2390
                     /product="spectrin beta chain, non-erythrocytic 2 isoform
                     X1"
                     /calculated_mol_wt=271165
     Region          43..159
                     /region_name="CH_SPTB-like_rpt1"
                     /note="first calponin homology (CH) domain found in the
                     beta-I spectrin-like subfamily; cd21246"
                     /db_xref="CDD:409095"
     Site            order(44,47..48,51..52,55..56,59,113,116..117,120,127,
                     132..140,147..148,150..151,154..155,158..159)
                     /site_type="other"
                     /note="actin binding site [polypeptide binding]"
                     /db_xref="CDD:409095"
     Region          173..291
                     /region_name="CH_SPTBN2_rpt2"
                     /note="second calponin homology (CH) domain found in
                     spectrin beta chain, non-erythrocytic 2 (SPTBN2) and
                     similar proteins; cd21321"
                     /db_xref="CDD:409170"
     Site            order(178,182,232,234..235,238,245,250..258,267..268,
                     270..271,274..275,278)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409170"
     Region          305..414
                     /region_name="Spectrin"
                     /note="Spectrin repeat; pfam00435"
                     /db_xref="CDD:395348"
     Site            416..421
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          429..522
                     /region_name="Spectrin"
                     /note="Spectrin repeat; pfam00435"
                     /db_xref="CDD:395348"
     Region          534..746
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            640..645
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          749..958
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            851..856
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          961..1172
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1064..1069
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1174..1383
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1277..1282
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1384..1588
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1487..1492
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1589..1801
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1693..1698
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1802..2010
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1906..1911
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          2018..>2075
                     /region_name="SPEC"
                     /note="Spectrin repeats; smart00150"
                     /db_xref="CDD:197544"
     Region          <2097..>2241
                     /region_name="dnaA"
                     /note="chromosomal replication initiator protein DnaA;
                     cl42516"
                     /db_xref="CDD:455861"
     Region          2221..2324
                     /region_name="PH_beta_spectrin"
                     /note="Beta-spectrin pleckstrin homology (PH) domain;
                     cd10571"
                     /db_xref="CDD:269975"
     Site            order(2228,2241..2243,2289)
                     /site_type="other"
                     /note="non-cannonical phosphoinositide binding site
                     [chemical binding]"
                     /db_xref="CDD:269975"
     CDS             1..2390
                     /gene="SPTBN2"
                     /gene_synonym="GTRAP41; SCA5; SCAR14"
                     /coded_by="XM_054369749.1:261..7433"
                     /db_xref="GeneID:6712"
                     /db_xref="HGNC:HGNC:11276"
                     /db_xref="MIM:604985"
ORIGIN      
        1 msstlsptdf dsleiqgqys dinnrwdlpd sdwdndsssa rlfersrika ladereavqk
       61 ktftkwvnsh larvtcrvgd lysdlrdgrn llrllevlsg eilpkptkgr mrihclenvd
      121 kalqflkeqk vhlenmgshd ivdgnhrltl glvwtiilrf qiqdisvete dnkekksakd
      181 alllwcqmkt agypnvnvhn fttswrdgla fnaivhkhrp dlldfeslkk cnahynlqna
      241 fnlaekelgl tklldpedvn vdqpdeksii tyvatyyhyf skmkalaveg krigkvldha
      301 meaerlveky eslasellqw ieqtivtlnd rqlanslsgv qnqlqsfnsy rtvekppkft
      361 ekgnlevllf tiqsklrann qkvytpregr lisdinkawe rlekaehere lalrtelirq
      421 ekleqlaarf drkaamretw lsenqrlvsq dnfglelaav eaavrkheai etdivaysgr
      481 vqavdavaae laaeryhdik riaarqhnva rlwdflrqmv aarrerllln lelqkvfqdl
      541 lylmdwmeem kgrlqsqdlg rhlagvedll qlhelveadi avqaervrav sasalrfcnp
      601 gkeyrpcdpq lvservakle qsyealcela aarrarlees rrlwrflwev geaeawvreq
      661 qhllasadtg rdltgalrll nkhtalrgem sgrlgplklt leqgqqlvae ghpgasqasa
      721 raaelqaqwe rlealaeera qrlaqaasly qfqadandme awlvdalrlv sspelghdef
      781 stqalarqhr aleeeirshr ptldalreqa aalpptlsrt pevqgrvptl erhyeelqar
      841 ageraralea alalytmlse agacglwvee keqwlnglal perledlevv qqrfetlepe
      901 mntlaaqita vndiaeqllk anppgkdriv ntqeqlnhrw qqfrrladgk kaaltsalsi
      961 qnyhlectet qawmrektkv iestqglgnd lagvlalqrk lagterdlea iaarvgeltr
     1021 eanalaaghp aqavainarl revqtgwedl ratmrrrees lgearrlqdf lrslddfqaw
     1081 lgrtqtavas eegpatlpea eallaqhaal rgeveraqse ysrlralgee vtrdqadpqc
     1141 lflrqrleal gtgweelgrm wesrqgrlaq ahgfqgflrd arqaegvlss qeyvlshtem
     1201 pgtlqaadaa ikkledfmst mdangerihg lleagrqlvs egnihadkir ekadsierrh
     1261 kknqdaaqqf lgrlrdnreq qhflqdchel klwidekmlt aqdvsydear nlhtkwqkhq
     1321 afmaelaank dwldkvdkeg reltlekpel kalvseklrd lhrrwdelet ttqakarslf
     1381 danraelfaq sccaleswle slqaqlhsdd ygkdltsvni llkkqqmlew emavrekeve
     1441 aiqaqakala qedqgageve rtsraveekf ralcqpmrer crrlqasreq hqfhrdvede
     1501 ilwvterlpm assmehgkdl psvqllmkkn qtlqkeiqgh epriadlrer qralgaaaag
     1561 pelaelqemw krlghelelr gkrledalra qqfyrdaaea eawmgeqelh mmgqekakde
     1621 lsaqaevkkh qvleqalady aqtihqlaas sqdmidhehp estrisirqa qvdklyaglk
     1681 elagerrerl qehlrlcqlr relddleqwi qerevvaash elgqdyehvt mlrdkfrefs
     1741 rdtstigqer vdsanalang liagghaara tvaewkdsln eawadllell dtrgqvlaaa
     1801 yelqrflhga rqalarvqhk qqqlpdgtgr dlnaaealqr rhcayehdiq alspqvqqvq
     1861 ddghrlqkay agdkaeeigr hmqavaeawa qlqgssaarr qllldttdkf rffkavrelm
     1921 lwmdevnlqm daqerprdvs sadlviknqq gikaeieara drfsscidmg kellarshya
     1981 aeeiseklsq lqarrqetae kwqekmdwlq lvlevlvfgr dagmaeawlc sqeplvrsae
     2041 lgctvdeves likrheafqk savaweerfc alekltalee rekerkrkre eeerrkqppa
     2101 peptasvppg dlvggqtasd ttwdgtqprp ppstqapsvn gvctdgepsq pllgqqrleh
     2161 ssfpegpgpg sgdeangprg erqtrtrgpa psampqsrst esahaatlpp rgpepsaqeq
     2221 megmlcrkqe meafgkkaan rswqnvycvl rrgslgfykd akaasagvpy hgevpvslar
     2281 aqgsvafdyr krkhvfklgl qdgkeylfqa kdeaemsswl rvvnaaiata ssasgepeep
     2341 vvpsttrgmt ramtmppvsp vgaegpvvlr skdgrerere krfsffkknk
//
LOCUS       XP_054225725            2390 aa            linear   PRI 05-AUG-2025
DEFINITION  spectrin beta chain, non-erythrocytic 2 isoform X1 [Homo sapiens].
ACCESSION   XP_054225725
VERSION     XP_054225725.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369750.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2390
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2390
                     /product="spectrin beta chain, non-erythrocytic 2 isoform
                     X1"
                     /calculated_mol_wt=271165
     Region          43..159
                     /region_name="CH_SPTB-like_rpt1"
                     /note="first calponin homology (CH) domain found in the
                     beta-I spectrin-like subfamily; cd21246"
                     /db_xref="CDD:409095"
     Site            order(44,47..48,51..52,55..56,59,113,116..117,120,127,
                     132..140,147..148,150..151,154..155,158..159)
                     /site_type="other"
                     /note="actin binding site [polypeptide binding]"
                     /db_xref="CDD:409095"
     Region          173..291
                     /region_name="CH_SPTBN2_rpt2"
                     /note="second calponin homology (CH) domain found in
                     spectrin beta chain, non-erythrocytic 2 (SPTBN2) and
                     similar proteins; cd21321"
                     /db_xref="CDD:409170"
     Site            order(178,182,232,234..235,238,245,250..258,267..268,
                     270..271,274..275,278)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409170"
     Region          305..414
                     /region_name="Spectrin"
                     /note="Spectrin repeat; pfam00435"
                     /db_xref="CDD:395348"
     Site            416..421
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          429..522
                     /region_name="Spectrin"
                     /note="Spectrin repeat; pfam00435"
                     /db_xref="CDD:395348"
     Region          534..746
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            640..645
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          749..958
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            851..856
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          961..1172
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1064..1069
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1174..1383
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1277..1282
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1384..1588
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1487..1492
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1589..1801
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1693..1698
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1802..2010
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1906..1911
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          2018..>2075
                     /region_name="SPEC"
                     /note="Spectrin repeats; smart00150"
                     /db_xref="CDD:197544"
     Region          <2097..>2241
                     /region_name="dnaA"
                     /note="chromosomal replication initiator protein DnaA;
                     cl42516"
                     /db_xref="CDD:455861"
     Region          2221..2324
                     /region_name="PH_beta_spectrin"
                     /note="Beta-spectrin pleckstrin homology (PH) domain;
                     cd10571"
                     /db_xref="CDD:269975"
     Site            order(2228,2241..2243,2289)
                     /site_type="other"
                     /note="non-cannonical phosphoinositide binding site
                     [chemical binding]"
                     /db_xref="CDD:269975"
     CDS             1..2390
                     /gene="SPTBN2"
                     /gene_synonym="GTRAP41; SCA5; SCAR14"
                     /coded_by="XM_054369750.1:146..7318"
                     /db_xref="GeneID:6712"
                     /db_xref="HGNC:HGNC:11276"
                     /db_xref="MIM:604985"
ORIGIN      
        1 msstlsptdf dsleiqgqys dinnrwdlpd sdwdndsssa rlfersrika ladereavqk
       61 ktftkwvnsh larvtcrvgd lysdlrdgrn llrllevlsg eilpkptkgr mrihclenvd
      121 kalqflkeqk vhlenmgshd ivdgnhrltl glvwtiilrf qiqdisvete dnkekksakd
      181 alllwcqmkt agypnvnvhn fttswrdgla fnaivhkhrp dlldfeslkk cnahynlqna
      241 fnlaekelgl tklldpedvn vdqpdeksii tyvatyyhyf skmkalaveg krigkvldha
      301 meaerlveky eslasellqw ieqtivtlnd rqlanslsgv qnqlqsfnsy rtvekppkft
      361 ekgnlevllf tiqsklrann qkvytpregr lisdinkawe rlekaehere lalrtelirq
      421 ekleqlaarf drkaamretw lsenqrlvsq dnfglelaav eaavrkheai etdivaysgr
      481 vqavdavaae laaeryhdik riaarqhnva rlwdflrqmv aarrerllln lelqkvfqdl
      541 lylmdwmeem kgrlqsqdlg rhlagvedll qlhelveadi avqaervrav sasalrfcnp
      601 gkeyrpcdpq lvservakle qsyealcela aarrarlees rrlwrflwev geaeawvreq
      661 qhllasadtg rdltgalrll nkhtalrgem sgrlgplklt leqgqqlvae ghpgasqasa
      721 raaelqaqwe rlealaeera qrlaqaasly qfqadandme awlvdalrlv sspelghdef
      781 stqalarqhr aleeeirshr ptldalreqa aalpptlsrt pevqgrvptl erhyeelqar
      841 ageraralea alalytmlse agacglwvee keqwlnglal perledlevv qqrfetlepe
      901 mntlaaqita vndiaeqllk anppgkdriv ntqeqlnhrw qqfrrladgk kaaltsalsi
      961 qnyhlectet qawmrektkv iestqglgnd lagvlalqrk lagterdlea iaarvgeltr
     1021 eanalaaghp aqavainarl revqtgwedl ratmrrrees lgearrlqdf lrslddfqaw
     1081 lgrtqtavas eegpatlpea eallaqhaal rgeveraqse ysrlralgee vtrdqadpqc
     1141 lflrqrleal gtgweelgrm wesrqgrlaq ahgfqgflrd arqaegvlss qeyvlshtem
     1201 pgtlqaadaa ikkledfmst mdangerihg lleagrqlvs egnihadkir ekadsierrh
     1261 kknqdaaqqf lgrlrdnreq qhflqdchel klwidekmlt aqdvsydear nlhtkwqkhq
     1321 afmaelaank dwldkvdkeg reltlekpel kalvseklrd lhrrwdelet ttqakarslf
     1381 danraelfaq sccaleswle slqaqlhsdd ygkdltsvni llkkqqmlew emavrekeve
     1441 aiqaqakala qedqgageve rtsraveekf ralcqpmrer crrlqasreq hqfhrdvede
     1501 ilwvterlpm assmehgkdl psvqllmkkn qtlqkeiqgh epriadlrer qralgaaaag
     1561 pelaelqemw krlghelelr gkrledalra qqfyrdaaea eawmgeqelh mmgqekakde
     1621 lsaqaevkkh qvleqalady aqtihqlaas sqdmidhehp estrisirqa qvdklyaglk
     1681 elagerrerl qehlrlcqlr relddleqwi qerevvaash elgqdyehvt mlrdkfrefs
     1741 rdtstigqer vdsanalang liagghaara tvaewkdsln eawadllell dtrgqvlaaa
     1801 yelqrflhga rqalarvqhk qqqlpdgtgr dlnaaealqr rhcayehdiq alspqvqqvq
     1861 ddghrlqkay agdkaeeigr hmqavaeawa qlqgssaarr qllldttdkf rffkavrelm
     1921 lwmdevnlqm daqerprdvs sadlviknqq gikaeieara drfsscidmg kellarshya
     1981 aeeiseklsq lqarrqetae kwqekmdwlq lvlevlvfgr dagmaeawlc sqeplvrsae
     2041 lgctvdeves likrheafqk savaweerfc alekltalee rekerkrkre eeerrkqppa
     2101 peptasvppg dlvggqtasd ttwdgtqprp ppstqapsvn gvctdgepsq pllgqqrleh
     2161 ssfpegpgpg sgdeangprg erqtrtrgpa psampqsrst esahaatlpp rgpepsaqeq
     2221 megmlcrkqe meafgkkaan rswqnvycvl rrgslgfykd akaasagvpy hgevpvslar
     2281 aqgsvafdyr krkhvfklgl qdgkeylfqa kdeaemsswl rvvnaaiata ssasgepeep
     2341 vvpsttrgmt ramtmppvsp vgaegpvvlr skdgrerere krfsffkknk
//
LOCUS       XP_054225726            2372 aa            linear   PRI 05-AUG-2025
DEFINITION  spectrin beta chain, non-erythrocytic 2 isoform X2 [Homo sapiens].
ACCESSION   XP_054225726
VERSION     XP_054225726.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369751.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2372
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2372
                     /product="spectrin beta chain, non-erythrocytic 2 isoform
                     X2"
                     /calculated_mol_wt=268511
     Region          52..166
                     /region_name="CH_SPTB-like_rpt1"
                     /note="first calponin homology (CH) domain found in the
                     beta-I spectrin-like subfamily; cd21246"
                     /db_xref="CDD:409095"
     Site            order(54..55,58..59,62..63,66,120,123..124,127,134,
                     139..147,154..155,157..158,161..162,165..166)
                     /site_type="other"
                     /note="actin binding site [polypeptide binding]"
                     /db_xref="CDD:409095"
     Region          180..298
                     /region_name="CH_SPTBN2_rpt2"
                     /note="second calponin homology (CH) domain found in
                     spectrin beta chain, non-erythrocytic 2 (SPTBN2) and
                     similar proteins; cd21321"
                     /db_xref="CDD:409170"
     Site            order(185,189,239,241..242,245,252,257..265,274..275,
                     277..278,281..282,285)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409170"
     Region          312..421
                     /region_name="Spectrin"
                     /note="Spectrin repeat; pfam00435"
                     /db_xref="CDD:395348"
     Site            423..428
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          436..529
                     /region_name="Spectrin"
                     /note="Spectrin repeat; pfam00435"
                     /db_xref="CDD:395348"
     Region          541..753
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            647..652
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          756..965
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            858..863
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          968..1179
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1071..1076
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1181..1390
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1284..1289
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1391..1595
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1494..1499
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1596..1808
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1700..1705
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1809..2017
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1913..1918
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          2025..>2082
                     /region_name="SPEC"
                     /note="Spectrin repeats; smart00150"
                     /db_xref="CDD:197544"
     Region          <2104..>2248
                     /region_name="dnaA"
                     /note="chromosomal replication initiator protein DnaA;
                     cl42516"
                     /db_xref="CDD:455861"
     Region          2228..2320
                     /region_name="PH_beta_spectrin"
                     /note="Beta-spectrin pleckstrin homology (PH) domain;
                     cd10571"
                     /db_xref="CDD:269975"
     Site            order(2235,2248..2250,2296)
                     /site_type="other"
                     /note="non-cannonical phosphoinositide binding site
                     [chemical binding]"
                     /db_xref="CDD:269975"
     CDS             1..2372
                     /gene="SPTBN2"
                     /gene_synonym="GTRAP41; SCA5; SCAR14"
                     /coded_by="XM_054369751.1:687..7805"
                     /db_xref="GeneID:6712"
                     /db_xref="HGNC:HGNC:11276"
                     /db_xref="MIM:604985"
ORIGIN      
        1 mngngvsrvh gnglheasef yyeavegahn pgglllspaa finpaqyasv legrfkqlqd
       61 ereavqkktf tkwvnshlar vtcrvgdlys dlrdgrnllr llevlsgeil pkptkgrmri
      121 hclenvdkal qflkeqkvhl enmgshdivd gnhrltlglv wtiilrfqiq disvetednk
      181 ekksakdall lwcqmktagy pnvnvhnftt swrdglafna ivhkhrpdll dfeslkkcna
      241 hynlqnafnl aekelgltkl ldpedvnvdq pdeksiityv atyyhyfskm kalavegkri
      301 gkvldhamea erlvekyesl asellqwieq tivtlndrql anslsgvqnq lqsfnsyrtv
      361 ekppkftekg nlevllftiq sklrannqkv ytpregrlis dinkawerle kaeherelal
      421 rtelirqekl eqlaarfdrk aamretwlse nqrlvsqdnf glelaaveaa vrkheaietd
      481 ivaysgrvqa vdavaaelaa eryhdikria arqhnvarlw dflrqmvaar rerlllnlel
      541 qkvfqdllyl mdwmeemkgr lqsqdlgrhl agvedllqlh elveadiavq aervravsas
      601 alrfcnpgke yrpcdpqlvs ervakleqsy ealcelaaar rarleesrrl wrflwevgea
      661 eawvreqqhl lasadtgrdl tgalrllnkh talrgemsgr lgplkltleq gqqlvaeghp
      721 gasqasaraa elqaqwerle alaeeraqrl aqaaslyqfq adandmeawl vdalrlvssp
      781 elghdefstq alarqhrale eeirshrptl dalreqaaal pptlsrtpev qgrvptlerh
      841 yeelqarage raraleaala lytmlseaga cglwveekeq wlnglalper ledlevvqqr
      901 fetlepemnt laaqitavnd iaeqllkanp pgkdrivntq eqlnhrwqqf rrladgkkaa
      961 ltsalsiqny hlectetqaw mrektkvies tqglgndlag vlalqrklag terdleaiaa
     1021 rvgeltrean alaaghpaqa vainarlrev qtgwedlrat mrrreeslge arrlqdflrs
     1081 lddfqawlgr tqtavaseeg patlpeaeal laqhaalrge veraqseysr lralgeevtr
     1141 dqadpqclfl rqrlealgtg weelgrmwes rqgrlaqahg fqgflrdarq aegvlssqey
     1201 vlshtempgt lqaadaaikk ledfmstmda ngerihglle agrqlvsegn ihadkireka
     1261 dsierrhkkn qdaaqqflgr lrdnreqqhf lqdchelklw idekmltaqd vsydearnlh
     1321 tkwqkhqafm aelaankdwl dkvdkegrel tlekpelkal vseklrdlhr rwdeletttq
     1381 akarslfdan raelfaqscc aleswleslq aqlhsddygk dltsvnillk kqqmlewema
     1441 vrekeveaiq aqakalaqed qgageverts raveekfral cqpmrercrr lqasreqhqf
     1501 hrdvedeilw vterlpmass mehgkdlpsv qllmkknqtl qkeiqghepr iadlrerqra
     1561 lgaaaagpel aelqemwkrl ghelelrgkr ledalraqqf yrdaaeaeaw mgeqelhmmg
     1621 qekakdelsa qaevkkhqvl eqaladyaqt ihqlaassqd midhehpest risirqaqvd
     1681 klyaglkela gerrerlqeh lrlcqlrrel ddleqwiqer evvaashelg qdyehvtmlr
     1741 dkfrefsrdt stigqervds analanglia gghaaratva ewkdslneaw adllelldtr
     1801 gqvlaaayel qrflhgarqa larvqhkqqq lpdgtgrdln aaealqrrhc ayehdiqals
     1861 pqvqqvqddg hrlqkayagd kaeeigrhmq avaeawaqlq gssaarrqll ldttdkfrff
     1921 kavrelmlwm devnlqmdaq erprdvssad lviknqqgik aeiearadrf sscidmgkel
     1981 larshyaaee iseklsqlqa rrqetaekwq ekmdwlqlvl evlvfgrdag maeawlcsqe
     2041 plvrsaelgc tvdeveslik rheafqksav aweerfcale kltaleerek erkrkreeee
     2101 rrkqppapep tasvppgdlv ggqtasdttw dgtqprppps tqapsvngvc tdgepsqpll
     2161 gqqrlehssf pegpgpgsgd eangprgerq trtrgpapsa mpqsrstesa haatlpprgp
     2221 epsaqeqmeg mlcrkqemea fgkkaanrsw qnvycvlrrg slgfykdaka asagvpyhge
     2281 vpvslaraqg svafdyrkrk hvfklglqdg keylfqakde vscpscssls vpfqklpaad
     2341 spsfpvlplf pglvlcgktg cvrrphqaal pv
//
LOCUS       XP_054225727            1452 aa            linear   PRI 05-AUG-2025
DEFINITION  spectrin beta chain, non-erythrocytic 2 isoform X3 [Homo sapiens].
ACCESSION   XP_054225727
VERSION     XP_054225727.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369752.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1452
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1452
                     /product="spectrin beta chain, non-erythrocytic 2 isoform
                     X3"
                     /calculated_mol_wt=164793
     Region          50..166
                     /region_name="CH_SF"
                     /note="calponin homology (CH) domain superfamily; cl00030"
                     /db_xref="CDD:469584"
     Site            order(70,121,123..124,127..128,130,143..147,152,154..155,
                     157..158,161..162,165)
                     /site_type="other"
                     /note="actin binding site [polypeptide binding]"
                     /db_xref="CDD:409031"
     Region          180..298
                     /region_name="CH_SPTBN2_rpt2"
                     /note="second calponin homology (CH) domain found in
                     spectrin beta chain, non-erythrocytic 2 (SPTBN2) and
                     similar proteins; cd21321"
                     /db_xref="CDD:409170"
     Site            order(185,189,239,241..242,245,252,257..265,274..275,
                     277..278,281..282,285)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409170"
     Region          312..421
                     /region_name="Spectrin"
                     /note="Spectrin repeat; pfam00435"
                     /db_xref="CDD:395348"
     Site            423..428
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          436..529
                     /region_name="Spectrin"
                     /note="Spectrin repeat; pfam00435"
                     /db_xref="CDD:395348"
     Region          541..753
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            647..652
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          756..965
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            858..863
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          968..1179
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1071..1076
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1181..1350
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1284..1289
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     CDS             1..1452
                     /gene="SPTBN2"
                     /gene_synonym="GTRAP41; SCA5; SCAR14"
                     /coded_by="XM_054369752.1:2397..6755"
                     /db_xref="GeneID:6712"
                     /db_xref="HGNC:HGNC:11276"
                     /db_xref="MIM:604985"
ORIGIN      
        1 mngngvsrvh gnglheasef yyeavegahn pgglllspaa finpaqyasv legrfkqlqd
       61 ereavqkktf tkwvnshlar vtcrvgdlys dlrdgrnllr llevlsgeil pkptkgrmri
      121 hclenvdkal qflkeqkvhl enmgshdivd gnhrltlglv wtiilrfqiq disvetednk
      181 ekksakdall lwcqmktagy pnvnvhnftt swrdglafna ivhkhrpdll dfeslkkcna
      241 hynlqnafnl aekelgltkl ldpedvnvdq pdeksiityv atyyhyfskm kalavegkri
      301 gkvldhamea erlvekyesl asellqwieq tivtlndrql anslsgvqnq lqsfnsyrtv
      361 ekppkftekg nlevllftiq sklrannqkv ytpregrlis dinkawerle kaeherelal
      421 rtelirqekl eqlaarfdrk aamretwlse nqrlvsqdnf glelaaveaa vrkheaietd
      481 ivaysgrvqa vdavaaelaa eryhdikria arqhnvarlw dflrqmvaar rerlllnlel
      541 qkvfqdllyl mdwmeemkgr lqsqdlgrhl agvedllqlh elveadiavq aervravsas
      601 alrfcnpgke yrpcdpqlvs ervakleqsy ealcelaaar rarleesrrl wrflwevgea
      661 eawvreqqhl lasadtgrdl tgalrllnkh talrgemsgr lgplkltleq gqqlvaeghp
      721 gasqasaraa elqaqwerle alaeeraqrl aqaaslyqfq adandmeawl vdalrlvssp
      781 elghdefstq alarqhrale eeirshrptl dalreqaaal pptlsrtpev qgrvptlerh
      841 yeelqarage raraleaala lytmlseaga cglwveekeq wlnglalper ledlevvqqr
      901 fetlepemnt laaqitavnd iaeqllkanp pgkdrivntq eqlnhrwqqf rrladgkkaa
      961 ltsalsiqny hlectetqaw mrektkvies tqglgndlag vlalqrklag terdleaiaa
     1021 rvgeltrean alaaghpaqa vainarlrev qtgwedlrat mrrreeslge arrlqdflrs
     1081 lddfqawlgr tqtavaseeg patlpeaeal laqhaalrge veraqseysr lralgeevtr
     1141 dqadpqclfl rqrlealgtg weelgrmwes rqgrlaqahg fqgflrdarq aegvlssqey
     1201 vlshtempgt lqaadaaikk ledfmstmda ngerihglle agrqlvsegn ihadkireka
     1261 dsierrhkkn qdaaqqflgr lrdnreqqhf lqdchelklw idekmltaqd vsydearnlh
     1321 tkwqkhqafm aelaankdwl dkvdkavgqi tpwavcslpi lifescrpwf lvshpavpqe
     1381 srtdkalyll skypyrtwyv lnslrgtags tkrhfpflkg mmvgtkgdqc afkcfhsfsk
     1441 yllgatiska ly
//
LOCUS       XP_054225728            1432 aa            linear   PRI 05-AUG-2025
DEFINITION  spectrin beta chain, non-erythrocytic 2 isoform X4 [Homo sapiens].
ACCESSION   XP_054225728
VERSION     XP_054225728.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369753.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1432
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1432
                     /product="spectrin beta chain, non-erythrocytic 2 isoform
                     X4"
                     /calculated_mol_wt=162640
     Region          50..166
                     /region_name="CH_SF"
                     /note="calponin homology (CH) domain superfamily; cl00030"
                     /db_xref="CDD:469584"
     Site            order(70,121,123..124,127..128,130,143..147,152,154..155,
                     157..158,161..162,165)
                     /site_type="other"
                     /note="actin binding site [polypeptide binding]"
                     /db_xref="CDD:409031"
     Region          180..298
                     /region_name="CH_SPTBN2_rpt2"
                     /note="second calponin homology (CH) domain found in
                     spectrin beta chain, non-erythrocytic 2 (SPTBN2) and
                     similar proteins; cd21321"
                     /db_xref="CDD:409170"
     Site            order(185,189,239,241..242,245,252,257..265,274..275,
                     277..278,281..282,285)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409170"
     Region          312..421
                     /region_name="Spectrin"
                     /note="Spectrin repeat; pfam00435"
                     /db_xref="CDD:395348"
     Site            423..428
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          436..529
                     /region_name="Spectrin"
                     /note="Spectrin repeat; pfam00435"
                     /db_xref="CDD:395348"
     Region          541..753
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            647..652
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          756..965
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            858..863
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          968..1179
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1071..1076
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          1181..1350
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Site            1284..1289
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     CDS             1..1432
                     /gene="SPTBN2"
                     /gene_synonym="GTRAP41; SCA5; SCAR14"
                     /coded_by="XM_054369753.1:2396..6694"
                     /db_xref="GeneID:6712"
                     /db_xref="HGNC:HGNC:11276"
                     /db_xref="MIM:604985"
ORIGIN      
        1 mngngvsrvh gnglheasef yyeavegahn pgglllspaa finpaqyasv legrfkqlqd
       61 ereavqkktf tkwvnshlar vtcrvgdlys dlrdgrnllr llevlsgeil pkptkgrmri
      121 hclenvdkal qflkeqkvhl enmgshdivd gnhrltlglv wtiilrfqiq disvetednk
      181 ekksakdall lwcqmktagy pnvnvhnftt swrdglafna ivhkhrpdll dfeslkkcna
      241 hynlqnafnl aekelgltkl ldpedvnvdq pdeksiityv atyyhyfskm kalavegkri
      301 gkvldhamea erlvekyesl asellqwieq tivtlndrql anslsgvqnq lqsfnsyrtv
      361 ekppkftekg nlevllftiq sklrannqkv ytpregrlis dinkawerle kaeherelal
      421 rtelirqekl eqlaarfdrk aamretwlse nqrlvsqdnf glelaaveaa vrkheaietd
      481 ivaysgrvqa vdavaaelaa eryhdikria arqhnvarlw dflrqmvaar rerlllnlel
      541 qkvfqdllyl mdwmeemkgr lqsqdlgrhl agvedllqlh elveadiavq aervravsas
      601 alrfcnpgke yrpcdpqlvs ervakleqsy ealcelaaar rarleesrrl wrflwevgea
      661 eawvreqqhl lasadtgrdl tgalrllnkh talrgemsgr lgplkltleq gqqlvaeghp
      721 gasqasaraa elqaqwerle alaeeraqrl aqaaslyqfq adandmeawl vdalrlvssp
      781 elghdefstq alarqhrale eeirshrptl dalreqaaal pptlsrtpev qgrvptlerh
      841 yeelqarage raraleaala lytmlseaga cglwveekeq wlnglalper ledlevvqqr
      901 fetlepemnt laaqitavnd iaeqllkanp pgkdrivntq eqlnhrwqqf rrladgkkaa
      961 ltsalsiqny hlectetqaw mrektkvies tqglgndlag vlalqrklag terdleaiaa
     1021 rvgeltrean alaaghpaqa vainarlrev qtgwedlrat mrrreeslge arrlqdflrs
     1081 lddfqawlgr tqtavaseeg patlpeaeal laqhaalrge veraqseysr lralgeevtr
     1141 dqadpqclfl rqrlealgtg weelgrmwes rqgrlaqahg fqgflrdarq aegvlssqey
     1201 vlshtempgt lqaadaaikk ledfmstmda ngerihglle agrqlvsegn ihadkireka
     1261 dsierrhkkn qdaaqqflgr lrdnreqqhf lqdchelklw idekmltaqd vsydearnlh
     1321 tkwqkhqafm aelaankdwl dkvdkavgqi tpwavcslpi lifescrpwf lvshpavpqe
     1381 srtdkalyll skypyrtcsr ehtslttpdt eilkqkswkw gnqvglnlls lk
//
LOCUS       XP_054225729             688 aa            linear   PRI 05-AUG-2025
DEFINITION  signal recognition particle receptor subunit alpha isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225729
VERSION     XP_054225729.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369754.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..688
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..688
                     /product="signal recognition particle receptor subunit
                     alpha isoform X1"
                     /calculated_mol_wt=76175
     Region          28..296
                     /region_name="SRP-alpha_N"
                     /note="Signal recognition particle, alpha subunit,
                     N-terminal; pfam04086"
                     /db_xref="CDD:461165"
     Region          <301..523
                     /region_name="FlhF"
                     /note="flagellar biosynthetic protein FlhF; TIGR03499"
                     /db_xref="CDD:274609"
     Region          419..597
                     /region_name="SRalpha_C"
                     /note="C-terminal domain of signal recognition particle
                     receptor alpha subunit; cd17876"
                     /db_xref="CDD:349785"
     Site            order(427..428,457..460,463..464,467..468,494,523,
                     525..527,552,554..558,561,589,591..592,594)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:349785"
     CDS             1..688
                     /gene="SRPRA"
                     /gene_synonym="DP; Sralpha; SRPR"
                     /coded_by="XM_054369754.1:92..2158"
                     /db_xref="GeneID:6734"
                     /db_xref="HGNC:HGNC:11307"
                     /db_xref="MIM:182180"
ORIGIN      
        1 mldfftifsk gglvlwcfqg vsdsctgpvn alirsvllqe rggnnsfthe altlkykldn
       61 qfelvfvvgf qkiltltyvd kliddvhrlf rdkyrteiqq qsalsllngt fdfqndflrl
      121 lreaeesski rapttmkkfe dsekakkpvr smietrgekp kekaknskkk gakkegsdgp
      181 latskpvpae ksglpvgpen gvelskeeli rrkreefiqk hgrgmeksnk stksdapkek
      241 gkkaprvwel ggcankevld ystpttngtp eaalsedinl irgtgsggql qdldcsssdd
      301 egaaqnstkp satkgtlggm fgmlkglvgs kslsredmes vldkmrdhli aknvaadiav
      361 qlcesvankl egkvmgtfst vtstvkqalq eslvqilqpq rrvdmlrdim daqrrqrpyv
      421 vtfcgvngvg kstnlakisf wllengfsvl iaacdtfrag aveqlrthtr rlsalhppek
      481 hggrtmvqlf ekgygkdaag iameaiafar nqgfdvvlvd tagrmqdnap lmtalaklit
      541 vntpdlvlfv gealvgneav dqlvkfnral adhsmaqtpr lidgivltkf dtiddkvnvr
      601 leagmgvlhk gaeaarkswl qrflflrgrl ckdmlqenkg vhqkrgheiq qtenryrrdv
      661 keiirmmgmg nskyqernrt geqvsrvd
//
LOCUS       XP_054225730             634 aa            linear   PRI 05-AUG-2025
DEFINITION  signal recognition particle receptor subunit alpha isoform X2 [Homo
            sapiens].
ACCESSION   XP_054225730
VERSION     XP_054225730.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369755.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..634
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..634
                     /product="signal recognition particle receptor subunit
                     alpha isoform X2"
                     /calculated_mol_wt=69688
     Region          28..296
                     /region_name="SRP-alpha_N"
                     /note="Signal recognition particle, alpha subunit,
                     N-terminal; pfam04086"
                     /db_xref="CDD:461165"
     Region          <301..523
                     /region_name="FlhF"
                     /note="flagellar biosynthetic protein FlhF; TIGR03499"
                     /db_xref="CDD:274609"
     Region          419..597
                     /region_name="SRalpha_C"
                     /note="C-terminal domain of signal recognition particle
                     receptor alpha subunit; cd17876"
                     /db_xref="CDD:349785"
     Site            order(427..428,457..460,463..464,467..468,494,523,
                     525..527,552,554..558,561,589,591..592,594)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:349785"
     CDS             1..634
                     /gene="SRPRA"
                     /gene_synonym="DP; Sralpha; SRPR"
                     /coded_by="XM_054369755.1:92..1996"
                     /db_xref="GeneID:6734"
                     /db_xref="HGNC:HGNC:11307"
                     /db_xref="MIM:182180"
ORIGIN      
        1 mldfftifsk gglvlwcfqg vsdsctgpvn alirsvllqe rggnnsfthe altlkykldn
       61 qfelvfvvgf qkiltltyvd kliddvhrlf rdkyrteiqq qsalsllngt fdfqndflrl
      121 lreaeesski rapttmkkfe dsekakkpvr smietrgekp kekaknskkk gakkegsdgp
      181 latskpvpae ksglpvgpen gvelskeeli rrkreefiqk hgrgmeksnk stksdapkek
      241 gkkaprvwel ggcankevld ystpttngtp eaalsedinl irgtgsggql qdldcsssdd
      301 egaaqnstkp satkgtlggm fgmlkglvgs kslsredmes vldkmrdhli aknvaadiav
      361 qlcesvankl egkvmgtfst vtstvkqalq eslvqilqpq rrvdmlrdim daqrrqrpyv
      421 vtfcgvngvg kstnlakisf wllengfsvl iaacdtfrag aveqlrthtr rlsalhppek
      481 hggrtmvqlf ekgygkdaag iameaiafar nqgfdvvlvd tagrmqdnap lmtalaklit
      541 vntpdlvlfv gealvgneav dqlvkfnral adhsmaqtpr lidgivltkf dtiddkvnvr
      601 leagmgvlhk gaeaarkswl qrflflrgfk mhlt
//
LOCUS       XP_054225731             875 aa            linear   PRI 05-AUG-2025
DEFINITION  FACT complex subunit SSRP1 isoform X1 [Homo sapiens].
ACCESSION   XP_054225731
VERSION     XP_054225731.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369756.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..875
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..875
                     /product="FACT complex subunit SSRP1 isoform X1"
                     /calculated_mol_wt=97805
     Region          187..646
                     /region_name="POB3"
                     /note="Nucleosome-binding factor SPN, POB3 subunit
                     [Transcription / DNA replication, recombination, and
                     repair / Chromatin structure and dynamics]; COG5165"
                     /db_xref="CDD:227494"
     Region          715..781
                     /region_name="HMG-box_SSRP1-like"
                     /note="high mobility group (HMG)-box found in
                     structure-specific recognition protein 1 (SSRP1) and
                     similar proteins; cd21994"
                     /db_xref="CDD:438810"
     Site            order(715,717..718,720..721,724..725,728,732,740..741,
                     744..745,748,751..752,773,777,781)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:438810"
     CDS             1..875
                     /gene="SSRP1"
                     /gene_synonym="FACT; FACT80; T160"
                     /coded_by="XM_054369756.1:268..2895"
                     /db_xref="GeneID:6749"
                     /db_xref="HGNC:HGNC:11327"
                     /db_xref="MIM:604328"
ORIGIN      
        1 mwgggepwvw grgvvgavrg kpctlswigs ramcglladp gvpllvamap agaaragvgl
       61 gvsgipgpvl hpgldldpra lqrpsvgfqa eeilrhpgaa gscylapsvs tarcclscls
      121 vfllnsdsqp aehphthsgv gaqlpvylvs lvqpgalprp pqagvdmaet lefndvyqev
      181 kgsmndgrlr lsrqgiifkn sktgkvdniq ageltegiwr rvalghglkl ltknghvyky
      241 dgfresefek lsdffkthyr lelmekdlcv kgwnwgtvkf ggqllsfdig dqpvfeipls
      301 nvsqcttgkn evtlefhqnd daevslmevr fyvpptqedg vdpveafaqn vlskadviqa
      361 tgdaicifre lqcltprgry diriyptflh lhgktfdyki pyttvlrlfl lphkdqrqmf
      421 fvisldppik qgqtryhfli llfskdedis ltlnmneeev ekrfegrltk nmsgslyemv
      481 srvmkalvnr kitvpgnfqg hsgaqcitcs ykassgllyp lergfiyvhk ppvhirfdei
      541 sfvnfargtt ttrsfdfeie tkqgtqytfs siereeygkl fdfvnakkln iknrglkegm
      601 npsydeyads dedqhdayle rmkeegkire enandssdds geetdesfnp geeeedvaee
      661 fdsnasasss snegdsdrde kkrkqlkkak makdrksrkk pvevkkgkdp napkrpmsay
      721 mlwlnasrek iksdhpgisi tdlskkagei wkgmskekke ewdrkaedar rdyekamkey
      781 eggrgesskr dkskkkkkvk vkmekkstps rgsssksssr qlsesfkske fvssdesssg
      841 enkskkkrrr sedseeeela stppssedsa sgsde
//
LOCUS       XP_054225732             709 aa            linear   PRI 05-AUG-2025
DEFINITION  FACT complex subunit SSRP1 isoform X2 [Homo sapiens].
ACCESSION   XP_054225732
VERSION     XP_054225732.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369757.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..709
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..709
                     /product="FACT complex subunit SSRP1 isoform X2"
                     /calculated_mol_wt=80944
     Region          21..480
                     /region_name="POB3"
                     /note="Nucleosome-binding factor SPN, POB3 subunit
                     [Transcription / DNA replication, recombination, and
                     repair / Chromatin structure and dynamics]; COG5165"
                     /db_xref="CDD:227494"
     Region          549..615
                     /region_name="HMG-box_SSRP1-like"
                     /note="high mobility group (HMG)-box found in
                     structure-specific recognition protein 1 (SSRP1) and
                     similar proteins; cd21994"
                     /db_xref="CDD:438810"
     Site            order(549,551..552,554..555,558..559,562,566,574..575,
                     578..579,582,585..586,607,611,615)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:438810"
     CDS             1..709
                     /gene="SSRP1"
                     /gene_synonym="FACT; FACT80; T160"
                     /coded_by="XM_054369757.1:290..2419"
                     /db_xref="GeneID:6749"
                     /db_xref="HGNC:HGNC:11327"
                     /db_xref="MIM:604328"
ORIGIN      
        1 maetlefndv yqevkgsmnd grlrlsrqgi ifknsktgkv dniqagelte giwrrvalgh
       61 glklltkngh vykydgfres efeklsdffk thyrlelmek dlcvkgwnwg tvkfggqlls
      121 fdigdqpvfe iplsnvsqct tgknevtlef hqnddaevsl mevrfyvppt qedgvdpvea
      181 faqnvlskad viqatgdaic ifrelqcltp rgrydiriyp tflhlhgktf dykipyttvl
      241 rlfllphkdq rqmffvisld ppikqgqtry hflillfskd edisltlnmn eeevekrfeg
      301 rltknmsgsl yemvsrvmka lvnrkitvpg nfqghsgaqc itcsykassg llyplergfi
      361 yvhkppvhir fdeisfvnfa rgttttrsfd feietkqgtq ytfssieree ygklfdfvna
      421 kklniknrgl kegmnpsyde yadsdedqhd aylermkeeg kireenands sddsgeetde
      481 sfnpgeeeed vaeefdsnas assssnegds drdekkrkql kkakmakdrk srkkpvevkk
      541 gkdpnapkrp msaymlwlna srekiksdhp gisitdlskk ageiwkgmsk ekkeewdrka
      601 edarrdyeka mkeyeggrge sskrdkskkk kkvkvkmekk stpsrgsssk sssrqlsesf
      661 kskefvssde sssgenkskk krrrsedsee eelastppss edsasgsde
//
LOCUS       XP_054225733             641 aa            linear   PRI 05-AUG-2025
DEFINITION  FACT complex subunit SSRP1 isoform X3 [Homo sapiens].
ACCESSION   XP_054225733
VERSION     XP_054225733.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369758.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..641
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..641
                     /product="FACT complex subunit SSRP1 isoform X3"
                     /calculated_mol_wt=71218
     Region          187..602
                     /region_name="POB3"
                     /note="Nucleosome-binding factor SPN, POB3 subunit
                     [Transcription / DNA replication, recombination, and
                     repair / Chromatin structure and dynamics]; COG5165"
                     /db_xref="CDD:227494"
     CDS             1..641
                     /gene="SSRP1"
                     /gene_synonym="FACT; FACT80; T160"
                     /coded_by="XM_054369758.1:252..2177"
                     /db_xref="GeneID:6749"
                     /db_xref="HGNC:HGNC:11327"
                     /db_xref="MIM:604328"
ORIGIN      
        1 mwgggepwvw grgvvgavrg kpctlswigs ramcglladp gvpllvamap agaaragvgl
       61 gvsgipgpvl hpgldldpra lqrpsvgfqa eeilrhpgaa gscylapsvs tarcclscls
      121 vfllnsdsqp aehphthsgv gaqlpvylvs lvqpgalprp pqagvdmaet lefndvyqev
      181 kgsmndgrlr lsrqgiifkn sktgkvdniq ageltegiwr rvalghglkl ltknghvyky
      241 dgfresefek lsdffkthyr lelmekdlcv kgwnwgtvkf ggqllsfdig dqpvfeipls
      301 nvsqcttgkn evtlefhqnd daevslmevr fyvpptqedg vdpveafaqn vlskadviqa
      361 tgdaicifre lqcltprgry diriyptflh lhgktfdyki pyttvlrlfl lphkdqrqmf
      421 fvisldppik qgqtryhfli llfskdedis ltlnmneeev ekrfegrltk nmsgslyemv
      481 srvmkalvnr kitvpgnfqg hsgaqcitcs ykassgllyp lergfiyvhk ppvhirfdei
      541 sfvnfargtt ttrsfdfeie tkqgtqytfs siereeygkl fdfvnakkln iknrglkekk
      601 evrvtlspsw crfplhdlrp vyaapqeppv glgeggawgl d
//
LOCUS       XP_054225734             281 aa            linear   PRI 05-AUG-2025
DEFINITION  syntaxin-3 isoform X7 [Homo sapiens].
ACCESSION   XP_054225734
VERSION     XP_054225734.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369759.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..281
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..281
                     /product="syntaxin-3 isoform X7"
                     /calculated_mol_wt=32073
     Region          26..218
                     /region_name="Syntaxin"
                     /note="pfam00804"
                     /db_xref="CDD:459942"
     Region          186..252
                     /region_name="SNARE"
                     /note="SNARE motif; cl22856"
                     /db_xref="CDD:473982"
     Site            order(214,221,224)
                     /site_type="other"
                     /note="flanking leucine-zipper layers"
                     /db_xref="CDD:277229"
     Site            217
                     /site_type="active"
                     /note="zero layer [active]"
                     /db_xref="CDD:277229"
     CDS             1..281
                     /gene="STX3"
                     /gene_synonym="DIAR12; MVID2; RDMVID; STX3A"
                     /coded_by="XM_054369759.1:16..861"
                     /db_xref="GeneID:6809"
                     /db_xref="HGNC:HGNC:11438"
                     /db_xref="MIM:600876"
ORIGIN      
        1 mmkqltqddd tdaveiaidn tafmdeffse ieetrlnidk isehveeakk lysiilsapi
       61 pepktkddle qltteikkra nnvrnklksm ekhieedevr ssadlrirks qhsvlsrkfv
      121 evmtkyneaq vdfrerskgr iqrqleitgk kttdeeleem lesgnpaift sgiidsqisk
      181 qalseiegrh kdivrlessi kelhdmfmdi amlvenqgem ldnielnvmh tvdhvekard
      241 etkkavkyqs qarkkliiii vlvvvllgil aliiglsvgl n
//
LOCUS       XP_054225735             279 aa            linear   PRI 05-AUG-2025
DEFINITION  syntaxin-3 isoform X8 [Homo sapiens].
ACCESSION   XP_054225735
VERSION     XP_054225735.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369760.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..279
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..279
                     /product="syntaxin-3 isoform X8"
                     /calculated_mol_wt=31971
     Region          26..218
                     /region_name="Syntaxin"
                     /note="pfam00804"
                     /db_xref="CDD:459942"
     Region          186..252
                     /region_name="SNARE"
                     /note="SNARE motif; cl22856"
                     /db_xref="CDD:473982"
     Site            order(214,221,224)
                     /site_type="other"
                     /note="flanking leucine-zipper layers"
                     /db_xref="CDD:277229"
     Site            217
                     /site_type="active"
                     /note="zero layer [active]"
                     /db_xref="CDD:277229"
     CDS             1..279
                     /gene="STX3"
                     /gene_synonym="DIAR12; MVID2; RDMVID; STX3A"
                     /coded_by="XM_054369760.1:16..855"
                     /db_xref="GeneID:6809"
                     /db_xref="HGNC:HGNC:11438"
                     /db_xref="MIM:600876"
ORIGIN      
        1 mmkqltqddd tdaveiaidn tafmdeffse ieetrlnidk isehveeakk lysiilsapi
       61 pepktkddle qltteikkra nnvrnklksm ekhieedevr ssadlrirks qhsvlsrkfv
      121 evmtkyneaq vdfrerskgr iqrqleitgk kttdeeleem lesgnpaift sgiidsqisk
      181 qalseiegrh kdivrlessi kelhdmfmdi amlvenqgem ldnielnvmh tvdhvekard
      241 etkkavkyqs qarkkkimim icciilaiil astigsifa
//
LOCUS       XP_054225736             279 aa            linear   PRI 05-AUG-2025
DEFINITION  syntaxin-3 isoform X8 [Homo sapiens].
ACCESSION   XP_054225736
VERSION     XP_054225736.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369761.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..279
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..279
                     /product="syntaxin-3 isoform X8"
                     /calculated_mol_wt=31971
     Region          26..218
                     /region_name="Syntaxin"
                     /note="pfam00804"
                     /db_xref="CDD:459942"
     Region          186..252
                     /region_name="SNARE"
                     /note="SNARE motif; cl22856"
                     /db_xref="CDD:473982"
     Site            order(214,221,224)
                     /site_type="other"
                     /note="flanking leucine-zipper layers"
                     /db_xref="CDD:277229"
     Site            217
                     /site_type="active"
                     /note="zero layer [active]"
                     /db_xref="CDD:277229"
     CDS             1..279
                     /gene="STX3"
                     /gene_synonym="DIAR12; MVID2; RDMVID; STX3A"
                     /coded_by="XM_054369761.1:16..855"
                     /db_xref="GeneID:6809"
                     /db_xref="HGNC:HGNC:11438"
                     /db_xref="MIM:600876"
ORIGIN      
        1 mmkqltqddd tdaveiaidn tafmdeffse ieetrlnidk isehveeakk lysiilsapi
       61 pepktkddle qltteikkra nnvrnklksm ekhieedevr ssadlrirks qhsvlsrkfv
      121 evmtkyneaq vdfrerskgr iqrqleitgk kttdeeleem lesgnpaift sgiidsqisk
      181 qalseiegrh kdivrlessi kelhdmfmdi amlvenqgem ldnielnvmh tvdhvekard
      241 etkkavkyqs qarkkkimim icciilaiil astigsifa
//
LOCUS       XP_054225741             252 aa            linear   PRI 05-AUG-2025
DEFINITION  syntaxin-3 isoform X6 [Homo sapiens].
ACCESSION   XP_054225741
VERSION     XP_054225741.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369766.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..252
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..252
                     /product="syntaxin-3 isoform X6"
                     /calculated_mol_wt=28729
     Region          34..225
                     /region_name="Syntaxin"
                     /note="pfam00804"
                     /db_xref="CDD:459942"
     CDS             1..252
                     /gene="STX3"
                     /gene_synonym="DIAR12; MVID2; RDMVID; STX3A"
                     /coded_by="XM_054369766.1:231..989"
                     /db_xref="GeneID:6809"
                     /db_xref="HGNC:HGNC:11438"
                     /db_xref="MIM:600876"
ORIGIN      
        1 mkdrleqlka kqltqdddtd aveiaidnta fmdeffseie etrlnidkis ehveeakkly
       61 siilsapipe pktkddleql tteikkrann vrnklksmek hieedevrss adlrirksqh
      121 svlsrkfvev mtkyneaqvd frerskgriq rqleitgkkt tdeeleemle sgnpaiftsg
      181 iidsqiskqa lseiegrhkd ivrlessike lhdmfmdiam lvenqkliii ivlvvvllgi
      241 laliiglsvg ln
//
LOCUS       XP_054225742             192 aa            linear   PRI 05-AUG-2025
DEFINITION  syntaxin-3 isoform X9 [Homo sapiens].
ACCESSION   XP_054225742
VERSION     XP_054225742.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369767.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..192
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..192
                     /product="syntaxin-3 isoform X9"
                     /calculated_mol_wt=21807
     Region          <1..129
                     /region_name="Syntaxin"
                     /note="pfam00804"
                     /db_xref="CDD:459942"
     Region          97..163
                     /region_name="SNARE"
                     /note="SNARE motif; cl22856"
                     /db_xref="CDD:473982"
     Site            order(125,132,135)
                     /site_type="other"
                     /note="flanking leucine-zipper layers"
                     /db_xref="CDD:277229"
     Site            128
                     /site_type="active"
                     /note="zero layer [active]"
                     /db_xref="CDD:277229"
     CDS             1..192
                     /gene="STX3"
                     /gene_synonym="DIAR12; MVID2; RDMVID; STX3A"
                     /coded_by="XM_054369767.1:162..740"
                     /db_xref="GeneID:6809"
                     /db_xref="HGNC:HGNC:11438"
                     /db_xref="MIM:600876"
ORIGIN      
        1 mekhieedev rssadlrirk sqhsvlsrkf vevmtkynea qvdfrerskg riqrqleitg
       61 kkttdeelee mlesgnpaif tsgiidsqis kqalseiegr hkdivrless ikelhdmfmd
      121 iamlvenqge mldnielnvm htvdhvekar detkkavkyq sqarkkliii ivlvvvllgi
      181 laliiglsvg ln
//
LOCUS       XP_054225743             355 aa            linear   PRI 05-AUG-2025
DEFINITION  syntaxin-5 isoform X1 [Homo sapiens].
ACCESSION   XP_054225743
VERSION     XP_054225743.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369768.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..355
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..355
                     /product="syntaxin-5 isoform X1"
                     /calculated_mol_wt=39542
     Region          53..74
                     /region_name="Syntaxin-5_N"
                     /note="Syntaxin-5 N-terminal, Sly1p-binding domain;
                     pfam11416"
                     /db_xref="CDD:463276"
     Region          <182..324
                     /region_name="COG5325"
                     /note="t-SNARE complex subunit, syntaxin [Intracellular
                     trafficking and secretion]"
                     /db_xref="CDD:227635"
     Region          266..338
                     /region_name="SNARE_syntaxin5"
                     /note="SNARE motif of syntaxin 5; cd15844"
                     /db_xref="CDD:277197"
     Site            order(267,269..270,272..277,279..281,283..284,286..288,
                     290..291,293..295,297..298,300..305,307..312,314..319,
                     321..323)
                     /site_type="other"
                     /note="heterotetramer interface [polypeptide binding]"
                     /db_xref="CDD:277197"
     Site            297
                     /site_type="other"
                     /note="zero layer"
                     /db_xref="CDD:277197"
     CDS             1..355
                     /gene="STX5"
                     /gene_synonym="CDG2AA; SED5; STX5A"
                     /coded_by="XM_054369768.1:388..1455"
                     /db_xref="GeneID:6811"
                     /db_xref="HGNC:HGNC:11440"
                     /db_xref="MIM:603189"
ORIGIN      
        1 miprkrygsk ntdqgvylgl sktqvlspat agssssdiap lpppvtlvpp ppdtmscrdr
       61 tqeflsacks lqtrqngiqt nkpalravrq rseftlmakr igkdlsntfa klekltilak
      121 rkslfddkav eieeltyiik qdinslnkqi aqlqdfvrak gsqsgrhlqt hsntivvslq
      181 sklasmsndf ksvlevrten lkqqrsrreq fsrapvsalp lapnhlggga vvlgaeshas
      241 kdvaidmmds rtsqqlqlid eqdsyiqsra dtmqniesti velgsifqql ahmvkeqeet
      301 iqridenvlg aqldveaahs eilkyfqsvt snrwlmvkif lilivffiif vvfla
//
LOCUS       XP_054225744             259 aa            linear   PRI 05-AUG-2025
DEFINITION  syntaxin-5 isoform X2 [Homo sapiens].
ACCESSION   XP_054225744
VERSION     XP_054225744.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369769.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..259
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..259
                     /product="syntaxin-5 isoform X2"
                     /calculated_mol_wt=29103
     Region          <86..228
                     /region_name="COG5325"
                     /note="t-SNARE complex subunit, syntaxin [Intracellular
                     trafficking and secretion]"
                     /db_xref="CDD:227635"
     Region          170..242
                     /region_name="SNARE_syntaxin5"
                     /note="SNARE motif of syntaxin 5; cd15844"
                     /db_xref="CDD:277197"
     Site            order(171,173..174,176..181,183..185,187..188,190..192,
                     194..195,197..199,201..202,204..209,211..216,218..223,
                     225..227)
                     /site_type="other"
                     /note="heterotetramer interface [polypeptide binding]"
                     /db_xref="CDD:277197"
     Site            201
                     /site_type="other"
                     /note="zero layer"
                     /db_xref="CDD:277197"
     CDS             1..259
                     /gene="STX5"
                     /gene_synonym="CDG2AA; SED5; STX5A"
                     /coded_by="XM_054369769.1:162..941"
                     /db_xref="GeneID:6811"
                     /db_xref="HGNC:HGNC:11440"
                     /db_xref="MIM:603189"
ORIGIN      
        1 makrigkdls ntfakleklt ilakrkslfd dkaveieelt yiikqdinsl nkqiaqlqdf
       61 vrakgsqsgr hlqthsntiv vslqsklasm sndfksvlev rtenlkqqrs rreqfsrapv
      121 salplapnhl gggavvlgae shaskdvaid mmdsrtsqql qlideqdsyi qsradtmqni
      181 estivelgsi fqqlahmvke qeetiqride nvlgaqldve aahseilkyf qsvtsnrwlm
      241 vkiflilivf fiifvvfla
//
LOCUS       XP_054225746             269 aa            linear   PRI 05-AUG-2025
DEFINITION  tetraspanin-4 isoform X4 [Homo sapiens].
ACCESSION   XP_054225746
VERSION     XP_054225746.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369771.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..269
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..269
                     /product="tetraspanin-4 isoform X4"
                     /calculated_mol_wt=29176
     Region          63..259
                     /region_name="Tetraspanin"
                     /note="Tetraspanin family; pfam00335"
                     /db_xref="CDD:459767"
     Region          136..233
                     /region_name="NET-5_like_LEL"
                     /note="Tetraspanin, extracellular domain or large
                     extracellular loop (LEL), NET-5_like family. Tetraspanins
                     are trans-membrane proteins with 4 trans-membrane
                     segments. Both the N- and C-termini lie on the
                     intracellular side of the membrane. This alignment
                     model...; cd03165"
                     /db_xref="CDD:239418"
     Site            order(137,142,146,148..149,152,168,171..172,175..176)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:239418"
     CDS             1..269
                     /gene="TSPAN4"
                     /gene_synonym="NAG-2; NAG2; TETRASPAN; TM4SF7; TSPAN-4"
                     /coded_by="XM_054369771.1:477..1286"
                     /db_xref="GeneID:7106"
                     /db_xref="HGNC:HGNC:11859"
                     /db_xref="MIM:602644"
ORIGIN      
        1 mecggagtst llavplgwga wgflgrthhl pahwsafrdp ehrlvsflwp aqlggcgvlg
       61 vgiwlaatqg sfatlsssfp slsaanllii tgafvmaigf vgclgaiken kcllltffll
      121 lllvflleat iailffaytd kidryaqqdl kkglhlygtq gnvgltnaws iiqtdfrccg
      181 vsnytdwfev ynatrvpdsc clefsescgl hapgtwwkap cyetvkvwlq enllavgifg
      241 lctalvqilg ltfamtmycq vvkadtyca
//
LOCUS       XP_054225753             261 aa            linear   PRI 05-AUG-2025
DEFINITION  troponin T, fast skeletal muscle isoform X1 [Homo sapiens].
ACCESSION   XP_054225753
VERSION     XP_054225753.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369778.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..261
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..261
                     /product="troponin T, fast skeletal muscle isoform X1"
                     /calculated_mol_wt=30843
     Region          65..201
                     /region_name="Troponin"
                     /note="pfam00992"
                     /db_xref="CDD:460018"
     CDS             1..261
                     /gene="TNNT3"
                     /gene_synonym="beta-TnTF; DA2B2; TNTF"
                     /coded_by="XM_054369778.1:79..864"
                     /db_xref="GeneID:7140"
                     /db_xref="HGNC:HGNC:11950"
                     /db_xref="MIM:600692"
ORIGIN      
        1 msdeeveqve eqyeeeeeaq eeaaevheev hepeevqeee kprpkltapk ipegekvdfd
       61 diqkkrqnkd lmelqalids hfearkkeee elvalkerie krraeraeqq riraekerer
      121 qnrlaeekar reeedakrra eddlkkkkal ssmganyssy lakadqkrgk kqtaremkkk
      181 ilaerrkpln idhlgedklr dkakelwetl hqleidkfef geklkrqkyd imnvrarvqm
      241 lakfskkagt pakgkvggrw k
//
LOCUS       XP_054225754             256 aa            linear   PRI 05-AUG-2025
DEFINITION  troponin T, fast skeletal muscle isoform X2 [Homo sapiens].
ACCESSION   XP_054225754
VERSION     XP_054225754.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369779.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..256
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..256
                     /product="troponin T, fast skeletal muscle isoform X2"
                     /calculated_mol_wt=30228
     Region          60..196
                     /region_name="Troponin"
                     /note="pfam00992"
                     /db_xref="CDD:460018"
     CDS             1..256
                     /gene="TNNT3"
                     /gene_synonym="beta-TnTF; DA2B2; TNTF"
                     /coded_by="XM_054369779.1:79..849"
                     /db_xref="GeneID:7140"
                     /db_xref="HGNC:HGNC:11950"
                     /db_xref="MIM:600692"
ORIGIN      
        1 msdeeveqve eqyeeeeeaq eeaaevheev hepeekprpk ltapkipege kvdfddiqkk
       61 rqnkdlmelq alidshfear kkeeeelval keriekrrae raeqqrirae kererqnrla
      121 eekarreeed akrraeddlk kkkalssmga nyssylakad qkrgkkqtar emkkkilaer
      181 rkplnidhlg edklrdkake lwetlhqlei dkfefgeklk rqkydimnvr arvqmlakfs
      241 kkagtpakgk vggrwk
//
LOCUS       XP_054225755             269 aa            linear   PRI 05-AUG-2025
DEFINITION  troponin T, fast skeletal muscle isoform X3 [Homo sapiens].
ACCESSION   XP_054225755
VERSION     XP_054225755.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369780.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..269
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..269
                     /product="troponin T, fast skeletal muscle isoform X3"
                     /calculated_mol_wt=31693
     Region          73..209
                     /region_name="Troponin"
                     /note="pfam00992"
                     /db_xref="CDD:460018"
     CDS             1..269
                     /gene="TNNT3"
                     /gene_synonym="beta-TnTF; DA2B2; TNTF"
                     /coded_by="XM_054369780.1:41..850"
                     /db_xref="GeneID:7140"
                     /db_xref="HGNC:HGNC:11950"
                     /db_xref="MIM:600692"
ORIGIN      
        1 msdeeveqve eqyeeeeeaq eeaaevheev hepeevqedt aeedaeeekp rpkltapkip
       61 egekvdfddi qkkrqnkdlm elqalidshf earkkeeeel valkeriekr raeraeqqri
      121 raekererqn rlaeekarre eedakrraed dlkkkkalss mganyssyla kadqkrgkkq
      181 taremkkkil aerrkplnid hlgedklrdk akelwetlhq leidkfefge klkrqkydit
      241 tlrsridqaq khskkagtpa kgkvggrwk
//
LOCUS       XP_054225756             265 aa            linear   PRI 05-AUG-2025
DEFINITION  troponin T, fast skeletal muscle isoform X4 [Homo sapiens].
ACCESSION   XP_054225756
VERSION     XP_054225756.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369781.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..265
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..265
                     /product="troponin T, fast skeletal muscle isoform X4"
                     /calculated_mol_wt=31231
     Region          69..205
                     /region_name="Troponin"
                     /note="pfam00992"
                     /db_xref="CDD:460018"
     CDS             1..265
                     /gene="TNNT3"
                     /gene_synonym="beta-TnTF; DA2B2; TNTF"
                     /coded_by="XM_054369781.1:41..838"
                     /db_xref="GeneID:7140"
                     /db_xref="HGNC:HGNC:11950"
                     /db_xref="MIM:600692"
ORIGIN      
        1 msdeeveqve eqyeeeeeaq eeaaevheee evqedtaeed aeeekprpkl tapkipegek
       61 vdfddiqkkr qnkdlmelqa lidshfeark keeeelvalk eriekrraer aeqqriraek
      121 ererqnrlae ekarreeeda krraeddlkk kkalssmgan yssylakadq krgkkqtare
      181 mkkkilaerr kplnidhlge dklrdkakel wetlhqleid kfefgeklkr qkydittlrs
      241 ridqaqkhsk kagtpakgkv ggrwk
//
LOCUS       XP_054225757             262 aa            linear   PRI 05-AUG-2025
DEFINITION  troponin T, fast skeletal muscle isoform X5 [Homo sapiens].
ACCESSION   XP_054225757
VERSION     XP_054225757.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369782.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..262
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..262
                     /product="troponin T, fast skeletal muscle isoform X5"
                     /calculated_mol_wt=30928
     Region          66..202
                     /region_name="Troponin"
                     /note="pfam00992"
                     /db_xref="CDD:460018"
     CDS             1..262
                     /gene="TNNT3"
                     /gene_synonym="beta-TnTF; DA2B2; TNTF"
                     /coded_by="XM_054369782.1:19..807"
                     /db_xref="GeneID:7140"
                     /db_xref="HGNC:HGNC:11950"
                     /db_xref="MIM:600692"
ORIGIN      
        1 msdeeveqve eqyeeeeeaq eevhepeevq edtaeedaee ekprpkltap kipegekvdf
       61 ddiqkkrqnk dlmelqalid shfearkkee eelvalkeri ekrraeraeq qriraekere
      121 rqnrlaeeka rreeedakrr aeddlkkkka lssmganyss ylakadqkrg kkqtaremkk
      181 kilaerrkpl nidhlgedkl rdkakelwet lhqleidkfe fgeklkrqky dittlrsrid
      241 qaqkhskkag tpakgkvggr wk
//
LOCUS       XP_054225758             257 aa            linear   PRI 05-AUG-2025
DEFINITION  troponin T, fast skeletal muscle isoform X6 [Homo sapiens].
ACCESSION   XP_054225758
VERSION     XP_054225758.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369783.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..257
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..257
                     /product="troponin T, fast skeletal muscle isoform X6"
                     /calculated_mol_wt=30370
     Region          61..197
                     /region_name="Troponin"
                     /note="pfam00992"
                     /db_xref="CDD:460018"
     CDS             1..257
                     /gene="TNNT3"
                     /gene_synonym="beta-TnTF; DA2B2; TNTF"
                     /coded_by="XM_054369783.1:41..814"
                     /db_xref="GeneID:7140"
                     /db_xref="HGNC:HGNC:11950"
                     /db_xref="MIM:600692"
ORIGIN      
        1 msdeeveqve eqyeeeeeaq eeaaevheee evqeeekprp kltapkipeg ekvdfddiqk
       61 krqnkdlmel qalidshfea rkkeeeelva lkeriekrra eraeqqrira ekererqnrl
      121 aeekarreee dakrraeddl kkkkalssmg anyssylaka dqkrgkkqta remkkkilae
      181 rrkplnidhl gedklrdkak elwetlhqle idkfefgekl krqkydittl rsridqaqkh
      241 skkagtpakg kvggrwk
//
LOCUS       XP_054225759             256 aa            linear   PRI 05-AUG-2025
DEFINITION  troponin T, fast skeletal muscle isoform X7 [Homo sapiens].
ACCESSION   XP_054225759
VERSION     XP_054225759.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369784.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..256
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..256
                     /product="troponin T, fast skeletal muscle isoform X7"
                     /calculated_mol_wt=30218
     Region          60..196
                     /region_name="Troponin"
                     /note="pfam00992"
                     /db_xref="CDD:460018"
     CDS             1..256
                     /gene="TNNT3"
                     /gene_synonym="beta-TnTF; DA2B2; TNTF"
                     /coded_by="XM_054369784.1:41..811"
                     /db_xref="GeneID:7140"
                     /db_xref="HGNC:HGNC:11950"
                     /db_xref="MIM:600692"
ORIGIN      
        1 msdeeveqve eqyeeeeeaq eeaaevheev hepeekprpk ltapkipege kvdfddiqkk
       61 rqnkdlmelq alidshfear kkeeeelval keriekrrae raeqqrirae kererqnrla
      121 eekarreeed akrraeddlk kkkalssmga nyssylakad qkrgkkqtar emkkkilaer
      181 rkplnidhlg edklrdkake lwetlhqlei dkfefgeklk rqkydittlr sridqaqkhs
      241 kkagtpakgk vggrwk
//
LOCUS       XP_054225760             254 aa            linear   PRI 05-AUG-2025
DEFINITION  troponin T, fast skeletal muscle isoform X8 [Homo sapiens].
ACCESSION   XP_054225760
VERSION     XP_054225760.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369785.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..254
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..254
                     /product="troponin T, fast skeletal muscle isoform X8"
                     /calculated_mol_wt=30067
     Region          58..194
                     /region_name="Troponin"
                     /note="pfam00992"
                     /db_xref="CDD:460018"
     CDS             1..254
                     /gene="TNNT3"
                     /gene_synonym="beta-TnTF; DA2B2; TNTF"
                     /coded_by="XM_054369785.1:19..783"
                     /db_xref="GeneID:7140"
                     /db_xref="HGNC:HGNC:11950"
                     /db_xref="MIM:600692"
ORIGIN      
        1 msdeeveqve eqyeeeeeaq eevhepeevq eeekprpklt apkipegekv dfddiqkkrq
       61 nkdlmelqal idshfearkk eeeelvalke riekrraera eqqriraeke rerqnrlaee
      121 karreeedak rraeddlkkk kalssmgany ssylakadqk rgkkqtarem kkkilaerrk
      181 plnidhlged klrdkakelw etlhqleidk fefgeklkrq kydittlrsr idqaqkhskk
      241 agtpakgkvg grwk
//
LOCUS       XP_054225761             252 aa            linear   PRI 05-AUG-2025
DEFINITION  troponin T, fast skeletal muscle isoform X9 [Homo sapiens].
ACCESSION   XP_054225761
VERSION     XP_054225761.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369786.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..252
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..252
                     /product="troponin T, fast skeletal muscle isoform X9"
                     /calculated_mol_wt=29756
     Region          56..192
                     /region_name="Troponin"
                     /note="pfam00992"
                     /db_xref="CDD:460018"
     CDS             1..252
                     /gene="TNNT3"
                     /gene_synonym="beta-TnTF; DA2B2; TNTF"
                     /coded_by="XM_054369786.1:40..798"
                     /db_xref="GeneID:7140"
                     /db_xref="HGNC:HGNC:11950"
                     /db_xref="MIM:600692"
ORIGIN      
        1 msdeeveqve eqyeeeeeaq eeaaevheee ekprpkltap kipegekvdf ddiqkkrqnk
       61 dlmelqalid shfearkkee eelvalkeri ekrraeraeq qriraekere rqnrlaeeka
      121 rreeedakrr aeddlkkkka lssmganyss ylakadqkrg kkqtaremkk kilaerrkpl
      181 nidhlgedkl rdkakelwet lhqleidkfe fgeklkrqky dittlrsrid qaqkhskkag
      241 tpakgkvggr wk
//
LOCUS       XP_054225762             251 aa            linear   PRI 05-AUG-2025
DEFINITION  troponin T, fast skeletal muscle isoform X10 [Homo sapiens].
ACCESSION   XP_054225762
VERSION     XP_054225762.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369787.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..251
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..251
                     /product="troponin T, fast skeletal muscle isoform X10"
                     /calculated_mol_wt=29562
     Region          55..191
                     /region_name="Troponin"
                     /note="pfam00992"
                     /db_xref="CDD:460018"
     CDS             1..251
                     /gene="TNNT3"
                     /gene_synonym="beta-TnTF; DA2B2; TNTF"
                     /coded_by="XM_054369787.1:19..774"
                     /db_xref="GeneID:7140"
                     /db_xref="HGNC:HGNC:11950"
                     /db_xref="MIM:600692"
ORIGIN      
        1 msdeeveqve eeaqeeaaev heeeevqeee kprpkltapk ipegekvdfd diqkkrqnkd
       61 lmelqalids hfearkkeee elvalkerie krraeraeqq riraekerer qnrlaeekar
      121 reeedakrra eddlkkkkal ssmganyssy lakadqkrgk kqtaremkkk ilaerrkpln
      181 idhlgedklr dkakelwetl hqleidkfef geklkrqkyd ittlrsridq aqkhskkagt
      241 pakgkvggrw k
//
LOCUS       XP_054225763             250 aa            linear   PRI 05-AUG-2025
DEFINITION  troponin T, fast skeletal muscle isoform X11 [Homo sapiens].
ACCESSION   XP_054225763
VERSION     XP_054225763.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369788.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..250
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..250
                     /product="troponin T, fast skeletal muscle isoform X11"
                     /calculated_mol_wt=29410
     Region          54..190
                     /region_name="Troponin"
                     /note="pfam00992"
                     /db_xref="CDD:460018"
     CDS             1..250
                     /gene="TNNT3"
                     /gene_synonym="beta-TnTF; DA2B2; TNTF"
                     /coded_by="XM_054369788.1:19..771"
                     /db_xref="GeneID:7140"
                     /db_xref="HGNC:HGNC:11950"
                     /db_xref="MIM:600692"
ORIGIN      
        1 msdeeveqve eeaqeeaaev heevhepeek prpkltapki pegekvdfdd iqkkrqnkdl
       61 melqalidsh fearkkeeee lvalkeriek rraeraeqqr iraekererq nrlaeekarr
      121 eeedakrrae ddlkkkkals smganyssyl akadqkrgkk qtaremkkki laerrkplni
      181 dhlgedklrd kakelwetlh qleidkfefg eklkrqkydi ttlrsridqa qkhskkagtp
      241 akgkvggrwk
//
LOCUS       XP_054225764             249 aa            linear   PRI 05-AUG-2025
DEFINITION  troponin T, fast skeletal muscle isoform X12 [Homo sapiens].
ACCESSION   XP_054225764
VERSION     XP_054225764.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369789.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..249
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..249
                     /product="troponin T, fast skeletal muscle isoform X12"
                     /calculated_mol_wt=29452
     Region          53..189
                     /region_name="Troponin"
                     /note="pfam00992"
                     /db_xref="CDD:460018"
     CDS             1..249
                     /gene="TNNT3"
                     /gene_synonym="beta-TnTF; DA2B2; TNTF"
                     /coded_by="XM_054369789.1:19..768"
                     /db_xref="GeneID:7140"
                     /db_xref="HGNC:HGNC:11950"
                     /db_xref="MIM:600692"
ORIGIN      
        1 msdeeveqve eqyeeeeeaq eevhepeekp rpkltapkip egekvdfddi qkkrqnkdlm
       61 elqalidshf earkkeeeel valkeriekr raeraeqqri raekererqn rlaeekarre
      121 eedakrraed dlkkkkalss mganyssyla kadqkrgkkq taremkkkil aerrkplnid
      181 hlgedklrdk akelwetlhq leidkfefge klkrqkydit tlrsridqaq khskkagtpa
      241 kgkvggrwk
//
LOCUS       XP_054225765             246 aa            linear   PRI 05-AUG-2025
DEFINITION  troponin T, fast skeletal muscle isoform X13 [Homo sapiens].
ACCESSION   XP_054225765
VERSION     XP_054225765.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369790.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..246
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..246
                     /product="troponin T, fast skeletal muscle isoform X13"
                     /calculated_mol_wt=28948
     Region          50..186
                     /region_name="Troponin"
                     /note="pfam00992"
                     /db_xref="CDD:460018"
     CDS             1..246
                     /gene="TNNT3"
                     /gene_synonym="beta-TnTF; DA2B2; TNTF"
                     /coded_by="XM_054369790.1:19..759"
                     /db_xref="GeneID:7140"
                     /db_xref="HGNC:HGNC:11950"
                     /db_xref="MIM:600692"
ORIGIN      
        1 msdeeveqve eeaqeeaaev heeeekprpk ltapkipege kvdfddiqkk rqnkdlmelq
       61 alidshfear kkeeeelval keriekrrae raeqqrirae kererqnrla eekarreeed
      121 akrraeddlk kkkalssmga nyssylakad qkrgkkqtar emkkkilaer rkplnidhlg
      181 edklrdkake lwetlhqlei dkfefgeklk rqkydittlr sridqaqkhs kkagtpakgk
      241 vggrwk
//
LOCUS       XP_054225766             245 aa            linear   PRI 05-AUG-2025
DEFINITION  troponin T, fast skeletal muscle isoform X14 [Homo sapiens].
ACCESSION   XP_054225766
VERSION     XP_054225766.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369791.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..245
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..245
                     /product="troponin T, fast skeletal muscle isoform X14"
                     /calculated_mol_wt=29000
     Region          49..185
                     /region_name="Troponin"
                     /note="pfam00992"
                     /db_xref="CDD:460018"
     CDS             1..245
                     /gene="TNNT3"
                     /gene_synonym="beta-TnTF; DA2B2; TNTF"
                     /coded_by="XM_054369791.1:19..756"
                     /db_xref="GeneID:7140"
                     /db_xref="HGNC:HGNC:11950"
                     /db_xref="MIM:600692"
ORIGIN      
        1 msdeeveqve eqyeeeeeaq eeeekprpkl tapkipegek vdfddiqkkr qnkdlmelqa
       61 lidshfeark keeeelvalk eriekrraer aeqqriraek ererqnrlae ekarreeeda
      121 krraeddlkk kkalssmgan yssylakadq krgkkqtare mkkkilaerr kplnidhlge
      181 dklrdkakel wetlhqleid kfefgeklkr qkydimnvra rvqmlakfsk kagtpakgkv
      241 ggrwk
//
LOCUS       XP_054225767             243 aa            linear   PRI 05-AUG-2025
DEFINITION  troponin T, fast skeletal muscle isoform X15 [Homo sapiens].
ACCESSION   XP_054225767
VERSION     XP_054225767.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369792.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..243
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..243
                     /product="troponin T, fast skeletal muscle isoform X15"
                     /calculated_mol_wt=28645
     Region          47..183
                     /region_name="Troponin"
                     /note="pfam00992"
                     /db_xref="CDD:460018"
     CDS             1..243
                     /gene="TNNT3"
                     /gene_synonym="beta-TnTF; DA2B2; TNTF"
                     /coded_by="XM_054369792.1:19..750"
                     /db_xref="GeneID:7140"
                     /db_xref="HGNC:HGNC:11950"
                     /db_xref="MIM:600692"
ORIGIN      
        1 msdeeveqve eeaqeevhep eekprpklta pkipegekvd fddiqkkrqn kdlmelqali
       61 dshfearkke eeelvalker iekrraerae qqriraeker erqnrlaeek arreeedakr
      121 raeddlkkkk alssmganys sylakadqkr gkkqtaremk kkilaerrkp lnidhlgedk
      181 lrdkakelwe tlhqleidkf efgeklkrqk ydittlrsri dqaqkhskka gtpakgkvgg
      241 rwk
//
LOCUS       XP_054225768             243 aa            linear   PRI 05-AUG-2025
DEFINITION  troponin T, fast skeletal muscle isoform X16 [Homo sapiens].
ACCESSION   XP_054225768
VERSION     XP_054225768.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369793.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..243
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..243
                     /product="troponin T, fast skeletal muscle isoform X16"
                     /calculated_mol_wt=28645
     Region          47..183
                     /region_name="Troponin"
                     /note="pfam00992"
                     /db_xref="CDD:460018"
     CDS             1..243
                     /gene="TNNT3"
                     /gene_synonym="beta-TnTF; DA2B2; TNTF"
                     /coded_by="XM_054369793.1:19..750"
                     /db_xref="GeneID:7140"
                     /db_xref="HGNC:HGNC:11950"
                     /db_xref="MIM:600692"
ORIGIN      
        1 msdeeveqve eeaqeevhep eekprpklta pkipegekvd fddiqkkrqn kdlmelqali
       61 dshfearkke eeelvalker iekrraerae qqriraeker erqnrlaeek arreeedakr
      121 raeddlkkkk alssmganys sylakadqkr gkkqtaremk kkilaerrkp lnidhlgedk
      181 lrdkakelwe tlhqleidkf efgeklkrqk ydittlrsri dqaqkhskka gtpakgkvgg
      241 rwk
//
LOCUS       XP_054225769             269 aa            linear   PRI 05-AUG-2025
DEFINITION  troponin T, fast skeletal muscle isoform X3 [Homo sapiens].
ACCESSION   XP_054225769
VERSION     XP_054225769.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369794.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..269
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..269
                     /product="troponin T, fast skeletal muscle isoform X3"
                     /calculated_mol_wt=31693
     Region          73..209
                     /region_name="Troponin"
                     /note="pfam00992"
                     /db_xref="CDD:460018"
     CDS             1..269
                     /gene="TNNT3"
                     /gene_synonym="beta-TnTF; DA2B2; TNTF"
                     /coded_by="XM_054369794.1:277..1086"
                     /db_xref="GeneID:7140"
                     /db_xref="HGNC:HGNC:11950"
                     /db_xref="MIM:600692"
ORIGIN      
        1 msdeeveqve eqyeeeeeaq eeaaevheev hepeevqedt aeedaeeekp rpkltapkip
       61 egekvdfddi qkkrqnkdlm elqalidshf earkkeeeel valkeriekr raeraeqqri
      121 raekererqn rlaeekarre eedakrraed dlkkkkalss mganyssyla kadqkrgkkq
      181 taremkkkil aerrkplnid hlgedklrdk akelwetlhq leidkfefge klkrqkydit
      241 tlrsridqaq khskkagtpa kgkvggrwk
//
LOCUS       XP_054225770             263 aa            linear   PRI 05-AUG-2025
DEFINITION  troponin T, fast skeletal muscle isoform X17 [Homo sapiens].
ACCESSION   XP_054225770
VERSION     XP_054225770.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369795.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..263
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..263
                     /product="troponin T, fast skeletal muscle isoform X17"
                     /calculated_mol_wt=30886
     Region          67..203
                     /region_name="Troponin"
                     /note="pfam00992"
                     /db_xref="CDD:460018"
     CDS             1..263
                     /gene="TNNT3"
                     /gene_synonym="beta-TnTF; DA2B2; TNTF"
                     /coded_by="XM_054369795.1:79..870"
                     /db_xref="GeneID:7140"
                     /db_xref="HGNC:HGNC:11950"
                     /db_xref="MIM:600692"
ORIGIN      
        1 msdeeveqve eeaqeeaaev heevhepeev qedtaeedae eekprpklta pkipegekvd
       61 fddiqkkrqn kdlmelqali dshfearkke eeelvalker iekrraerae qqriraeker
      121 erqnrlaeek arreeedakr raeddlkkkk alssmganys sylakadqkr gkkqtaremk
      181 kkilaerrkp lnidhlgedk lrdkakelwe tlhqleidkf efgeklkrqk ydittlrsri
      241 dqaqkhskka gtpakgkvgg rwk
//
LOCUS       XP_054225771             256 aa            linear   PRI 05-AUG-2025
DEFINITION  troponin T, fast skeletal muscle isoform X18 [Homo sapiens].
ACCESSION   XP_054225771
VERSION     XP_054225771.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369796.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..256
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..256
                     /product="troponin T, fast skeletal muscle isoform X18"
                     /calculated_mol_wt=30120
     Region          60..196
                     /region_name="Troponin"
                     /note="pfam00992"
                     /db_xref="CDD:460018"
     CDS             1..256
                     /gene="TNNT3"
                     /gene_synonym="beta-TnTF; DA2B2; TNTF"
                     /coded_by="XM_054369796.1:79..849"
                     /db_xref="GeneID:7140"
                     /db_xref="HGNC:HGNC:11950"
                     /db_xref="MIM:600692"
ORIGIN      
        1 msdeeveqve eeaqeevhep eevqedtaee daeeekprpk ltapkipege kvdfddiqkk
       61 rqnkdlmelq alidshfear kkeeeelval keriekrrae raeqqrirae kererqnrla
      121 eekarreeed akrraeddlk kkkalssmga nyssylakad qkrgkkqtar emkkkilaer
      181 rkplnidhlg edklrdkake lwetlhqlei dkfefgeklk rqkydittlr sridqaqkhs
      241 kkagtpakgk vggrwk
//
LOCUS       XP_054225772             252 aa            linear   PRI 05-AUG-2025
DEFINITION  troponin T, fast skeletal muscle isoform X19 [Homo sapiens].
ACCESSION   XP_054225772
VERSION     XP_054225772.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369797.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..252
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..252
                     /product="troponin T, fast skeletal muscle isoform X19"
                     /calculated_mol_wt=29657
     Region          56..192
                     /region_name="Troponin"
                     /note="pfam00992"
                     /db_xref="CDD:460018"
     CDS             1..252
                     /gene="TNNT3"
                     /gene_synonym="beta-TnTF; DA2B2; TNTF"
                     /coded_by="XM_054369797.1:79..837"
                     /db_xref="GeneID:7140"
                     /db_xref="HGNC:HGNC:11950"
                     /db_xref="MIM:600692"
ORIGIN      
        1 msdeeveqve eeaqeeeevq edtaeedaee ekprpkltap kipegekvdf ddiqkkrqnk
       61 dlmelqalid shfearkkee eelvalkeri ekrraeraeq qriraekere rqnrlaeeka
      121 rreeedakrr aeddlkkkka lssmganyss ylakadqkrg kkqtaremkk kilaerrkpl
      181 nidhlgedkl rdkakelwet lhqleidkfe fgeklkrqky dittlrsrid qaqkhskkag
      241 tpakgkvggr wk
//
LOCUS       XP_054225773             249 aa            linear   PRI 05-AUG-2025
DEFINITION  troponin T, fast skeletal muscle isoform X20 [Homo sapiens].
ACCESSION   XP_054225773
VERSION     XP_054225773.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369798.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..249
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..249
                     /product="troponin T, fast skeletal muscle isoform X20"
                     /calculated_mol_wt=29452
     Region          53..189
                     /region_name="Troponin"
                     /note="pfam00992"
                     /db_xref="CDD:460018"
     CDS             1..249
                     /gene="TNNT3"
                     /gene_synonym="beta-TnTF; DA2B2; TNTF"
                     /coded_by="XM_054369798.1:79..828"
                     /db_xref="GeneID:7140"
                     /db_xref="HGNC:HGNC:11950"
                     /db_xref="MIM:600692"
ORIGIN      
        1 msdeeveqve eqyeeeeeaq eevhepeekp rpkltapkip egekvdfddi qkkrqnkdlm
       61 elqalidshf earkkeeeel valkeriekr raeraeqqri raekererqn rlaeekarre
      121 eedakrraed dlkkkkalss mganyssyla kadqkrgkkq taremkkkil aerrkplnid
      181 hlgedklrdk akelwetlhq leidkfefge klkrqkydit tlrsridqaq khskkagtpa
      241 kgkvggrwk
//
LOCUS       XP_054225774             245 aa            linear   PRI 05-AUG-2025
DEFINITION  troponin T, fast skeletal muscle isoform X21 [Homo sapiens].
ACCESSION   XP_054225774
VERSION     XP_054225774.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369799.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..245
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..245
                     /product="troponin T, fast skeletal muscle isoform X21"
                     /calculated_mol_wt=28990
     Region          49..185
                     /region_name="Troponin"
                     /note="pfam00992"
                     /db_xref="CDD:460018"
     CDS             1..245
                     /gene="TNNT3"
                     /gene_synonym="beta-TnTF; DA2B2; TNTF"
                     /coded_by="XM_054369799.1:79..816"
                     /db_xref="GeneID:7140"
                     /db_xref="HGNC:HGNC:11950"
                     /db_xref="MIM:600692"
ORIGIN      
        1 msdeeveqve eqyeeeeeaq eeeekprpkl tapkipegek vdfddiqkkr qnkdlmelqa
       61 lidshfeark keeeelvalk eriekrraer aeqqriraek ererqnrlae ekarreeeda
      121 krraeddlkk kkalssmgan yssylakadq krgkkqtare mkkkilaerr kplnidhlge
      181 dklrdkakel wetlhqleid kfefgeklkr qkydittlrs ridqaqkhsk kagtpakgkv
      241 ggrwk
//
LOCUS       XP_054225775             239 aa            linear   PRI 05-AUG-2025
DEFINITION  troponin T, fast skeletal muscle isoform X22 [Homo sapiens].
ACCESSION   XP_054225775
VERSION     XP_054225775.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369800.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..239
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..239
                     /product="troponin T, fast skeletal muscle isoform X22"
                     /calculated_mol_wt=28182
     Region          43..179
                     /region_name="Troponin"
                     /note="pfam00992"
                     /db_xref="CDD:460018"
     CDS             1..239
                     /gene="TNNT3"
                     /gene_synonym="beta-TnTF; DA2B2; TNTF"
                     /coded_by="XM_054369800.1:79..798"
                     /db_xref="GeneID:7140"
                     /db_xref="HGNC:HGNC:11950"
                     /db_xref="MIM:600692"
ORIGIN      
        1 msdeeveqve eeaqeeeekp rpkltapkip egekvdfddi qkkrqnkdlm elqalidshf
       61 earkkeeeel valkeriekr raeraeqqri raekererqn rlaeekarre eedakrraed
      121 dlkkkkalss mganyssyla kadqkrgkkq taremkkkil aerrkplnid hlgedklrdk
      181 akelwetlhq leidkfefge klkrqkydit tlrsridqaq khskkagtpa kgkvggrwk
//
LOCUS       XP_054225776             876 aa            linear   PRI 05-AUG-2025
DEFINITION  short transient receptor potential channel 6 isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225776
VERSION     XP_054225776.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369801.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..876
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..876
                     /product="short transient receptor potential channel 6
                     isoform X1"
                     /calculated_mol_wt=100331
     Region          27..842
                     /region_name="trp"
                     /note="transient-receptor-potential calcium channel
                     protein; TIGR00870"
                     /db_xref="CDD:273311"
     Site            order(52..54,56..57,61,64,75,77,79,83..84,87..89,91..92,
                     96,99,104,106,108,111..112,115..117,119..120,124,127)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          77..104
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          106..130
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          157..192
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     CDS             1..876
                     /gene="TRPC6"
                     /gene_synonym="FSGS2; TRP6"
                     /coded_by="XM_054369801.1:194..2824"
                     /db_xref="GeneID:7225"
                     /db_xref="HGNC:HGNC:12338"
                     /db_xref="MIM:603652"
ORIGIN      
        1 msrgsdnrla hrrqtvlrek grrlanrgpa ymfsdrstsl sieeerflda aeygnipvvr
       61 kmleechsln vncvdymgqn alqlavaneh leitelllkk enlsrvgdal llaiskgyvr
      121 iveailshpa faegkrlats psqselqqdd fyaydedgtr fshdvtpiil aahcqeyeiv
      181 htllrkgari erphdyfckc ndcnqkqkhd sfshsrsrin aykglaspay lslssedpvm
      241 talelsnela vlaniekefk ndykklsmqc kdfvvglldl crnteeveai lngdvetlqs
      301 gdhgrpnlsr lklaikyevk kfvahpncqq qllsiwyenl sglrqqtmav kflvvlavai
      361 glpflaliyw fapcskmgki mrgpfmkfva haasftiflg llvmnaadrf egtkllpnet
      421 stdnakqlfr mktscfswme mliiswvigm iwaeckeiwt qgpkeylfel wnmldfgmla
      481 ifaasfiarf mafwhaskaq siidandtlk dltkvtlgdn vkyynlarik wdpsdpqiis
      541 eglyaiavvl sfsriayilp anesfgplqi slgrtvkdif kfmvifimvf vafmigmfnl
      601 ysyyigakqn eafttveesf ktlfwaifgl sevksvviny nhkfienigy vlygvynvtm
      661 vivllnmlia minssfqeie ddadvewkfa raklwfsyfe egrtlpvpfn lvpspkslfy
      721 lllklkkwis elfqghkkgf qedaemnkin eekklgilgs hedlsklsld kkqvghnkqp
      781 sirssedfhl nsfnnpprqy qkimkrlikr yvlqaqidke sdevnegelk eikqdisslr
      841 yelleeksqn tedlaelire lgeklsmepn qeetnr
//
LOCUS       XP_054225777             832 aa            linear   PRI 05-AUG-2025
DEFINITION  short transient receptor potential channel 6 isoform X3 [Homo
            sapiens].
ACCESSION   XP_054225777
VERSION     XP_054225777.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369802.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..832
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..832
                     /product="short transient receptor potential channel 6
                     isoform X3"
                     /calculated_mol_wt=94443
     Region          82..775
                     /region_name="TRPV"
                     /note="Transient Receptor Potential channel, Vanilloid
                     subfamily (TRPV); cl40437"
                     /db_xref="CDD:454755"
     Site            order(107..109,111..112,116,119,130,132,134,138..139,
                     142..144,146..147,151,154,159,161,163,166..167,170..172,
                     174..175,179,182)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          132..159
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          161..185
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          212..247
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     CDS             1..832
                     /gene="TRPC6"
                     /gene_synonym="FSGS2; TRP6"
                     /coded_by="XM_054369802.1:505..3003"
                     /db_xref="GeneID:7225"
                     /db_xref="HGNC:HGNC:12338"
                     /db_xref="MIM:603652"
ORIGIN      
        1 msqspafgpr rgssprgaag aaarrnesqd yllmdselge dgcpqaplpc ygyypcfrgs
       61 dnrlahrrqt vlrekgrrla nrgpaymfsd rstslsieee rfldaaeygn ipvvrkmlee
      121 chslnvncvd ymgqnalqla vanehleite lllkkenlsr vgdalllais kgyvriveai
      181 lshpafaegk rlatspsqse lqqddfyayd edgtrfshdv tpiilaahcq eyeivhtllr
      241 kgarierphd yfckcndcnq kqkhdsfshs rsrinaykgl aspaylslss edpvmtalel
      301 snelavlani ekefkndykk lsmqckdfvv glldlcrnte eveailngdv etlqsgdhgr
      361 pnlsrlklai kyevkkfvah pncqqqllsi wyenlsglrq qtmavkflvv lavaiglpfl
      421 aliywfapcs kmgkimrgpf mkfvahaasf tiflgllvmn aadrfegtkl lpnetstdna
      481 kqlfrmktsc fswmemliis wvigmiwaec keiwtqgpke ylfelwnmld fgmlaifaas
      541 fiarfmafwh askaqsiida ndtlkdltkv tlgdnvkyyn larikwdpsd pqiiseglya
      601 iavvlsfsri ayilpanesf gplqislgrt vkdifkfmvi fimvfvafmi gmfnlysyyi
      661 gakqneaftt veesfktlfw aifglsevks vvinynhkfi enigyvlygv ynvtmvivll
      721 nmliaminss fqeieddadv ewkfaraklw fsyfeegrtl pvpfnlvpsp kslfylllkl
      781 kkwiselfqg hkkgfqedae mnkineekkl gilgshedls klsldkktgw aq
//
LOCUS       XP_054225779             338 aa            linear   PRI 05-AUG-2025
DEFINITION  tumor susceptibility gene 101 protein isoform X1 [Homo sapiens].
ACCESSION   XP_054225779
VERSION     XP_054225779.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369804.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..338
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..338
                     /product="tumor susceptibility gene 101 protein isoform
                     X1"
                     /calculated_mol_wt=37772
     Region          <1..87
                     /region_name="UEV"
                     /note="UEV domain; pfam05743"
                     /db_xref="CDD:399041"
     Region          159..>297
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          264..323
                     /region_name="Vps23_core"
                     /note="Vps23 core domain; pfam09454"
                     /db_xref="CDD:462803"
     CDS             1..338
                     /gene="TSG101"
                     /gene_synonym="TSG10; VPS23"
                     /coded_by="XM_054369804.1:325..1341"
                     /db_xref="GeneID:7251"
                     /db_xref="HGNC:HGNC:15971"
                     /db_xref="MIM:601387"
ORIGIN      
        1 mnltgtipvp yrgntynipi clwlldtypy nppicfvkpt ssmtiktgkh vdangkiylp
       61 ylhewkhpqs dllgliqvmi vvfgdeppvf srpisasypp yqatgppnts ympgmpggis
      121 pypsgyppnp sgypgcpypp ggpypattss qypsqppvtt vgpsrdgtis edtiraslis
      181 avsdklrwrm keemdraqae lnalkrteed lkkghqklee mvtrldqeva evdkniellk
      241 kkdeelssal ekmenqsenn dideviipta plykqilnly aeenaiedti fylgealrrg
      301 vidldvflkh vrllsrkqfq lralmqkark taglsdly
//
LOCUS       XP_054225780             680 aa            linear   PRI 05-AUG-2025
DEFINITION  calpain-5 isoform X1 [Homo sapiens].
ACCESSION   XP_054225780
VERSION     XP_054225780.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369805.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..680
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..680
                     /product="calpain-5 isoform X1"
                     /calculated_mol_wt=77162
     Region          67..381
                     /region_name="Peptidase_C2"
                     /note="Calpain family cysteine protease; pfam00648"
                     /db_xref="CDD:459889"
     Region          392..538
                     /region_name="Calpain_III"
                     /note="Calpain, subdomain III. Calpains are
                     calcium-activated cytoplasmic cysteine proteinases,
                     participate in cytoskeletal remodeling processes, cell
                     differentiation, apoptosis and signal transduction.
                     Catalytic domain and the two calmodulin-like domains
                     are...; cd00214"
                     /db_xref="CDD:238132"
     Region          555..678
                     /region_name="C2_Calpain"
                     /note="C2 domain present in Calpain proteins; cd04046"
                     /db_xref="CDD:176011"
     CDS             1..680
                     /gene="CAPN5"
                     /gene_synonym="ADNIV; HTRA3; nCL-3; VRNI"
                     /coded_by="XM_054369805.1:187..2229"
                     /db_xref="GeneID:726"
                     /db_xref="HGNC:HGNC:1482"
                     /db_xref="MIM:602537"
ORIGIN      
        1 msctgtpsci yllsalslqd lvldweprgv ppplpgaaat mfscvkpyed qnysalrrdc
       61 rrrkvlfedp lfpatddsly ykgtpgpavr wkrpkgiced prlfvdgiss hdlhqgqvgn
      121 cwfvaacssl asreslwqkv ipdwkeqewd pekpnayagi fhfhfwrfge wvdvviddrl
      181 ptvnnqliyc hsnsrnefwc alvekayakl agcyqaldgg ntadalvdft ggvsepidlt
      241 egdfandetk rnqlfermlk vhsrgglisa sikavtaadm earlacglvk ghayavtdvr
      301 kvrlghglla ffksekldmi rlrnpwgere wngpwsdtse ewqkvskser ekmgvtvqdd
      361 gefwmtfedv cryftdiikc rvintshlsi hktweearlh gawtlhedpr qnrgggcinh
      421 kdtffqnpqy ifevkkpede vliciqqrpk rstrregkge nlaigfdiyk veenrqyrmh
      481 slqhkaassi yinsrsvflr tdqpegryvi ipttfepght gefllrvftd vpsncrelrl
      541 depphtcwss lcgypqlvtq vhvlgaaglk dsptgansyv iikcegdkvr savqkgtstp
      601 eynvkgifyr kklsqpitvq vwnhrvlkde flgqvhlkad pdnlqalhtl hlrdrnsrqp
      661 snlpgtvavh ilsstslmav
//
LOCUS       XP_054225781             676 aa            linear   PRI 05-AUG-2025
DEFINITION  calpain-5 isoform X2 [Homo sapiens].
ACCESSION   XP_054225781
VERSION     XP_054225781.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369806.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..676
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..676
                     /product="calpain-5 isoform X2"
                     /calculated_mol_wt=76995
     Region          63..377
                     /region_name="Peptidase_C2"
                     /note="Calpain family cysteine protease; pfam00648"
                     /db_xref="CDD:459889"
     Region          388..534
                     /region_name="Calpain_III"
                     /note="Calpain, subdomain III. Calpains are
                     calcium-activated cytoplasmic cysteine proteinases,
                     participate in cytoskeletal remodeling processes, cell
                     differentiation, apoptosis and signal transduction.
                     Catalytic domain and the two calmodulin-like domains
                     are...; cd00214"
                     /db_xref="CDD:238132"
     Region          551..674
                     /region_name="C2_Calpain"
                     /note="C2 domain present in Calpain proteins; cd04046"
                     /db_xref="CDD:176011"
     CDS             1..676
                     /gene="CAPN5"
                     /gene_synonym="ADNIV; HTRA3; nCL-3; VRNI"
                     /coded_by="XM_054369806.1:2..2032"
                     /db_xref="GeneID:726"
                     /db_xref="HGNC:HGNC:1482"
                     /db_xref="MIM:602537"
ORIGIN      
        1 mrilkhkevn cfaprwpqsp hlrtgvpppl pgaaatmfsc vkpyedqnys alrrdcrrrk
       61 vlfedplfpa tddslyykgt pgpavrwkrp kgicedprlf vdgisshdlh qgqvgncwfv
      121 aacsslasre slwqkvipdw keqewdpekp nayagifhfh fwrfgewvdv viddrlptvn
      181 nqliychsns rnefwcalve kayaklagcy qaldggntad alvdftggvs epidltegdf
      241 andetkrnql fermlkvhsr gglisasika vtaadmearl acglvkghay avtdvrkvrl
      301 ghgllaffks ekldmirlrn pwgerewngp wsdtseewqk vskserekmg vtvqddgefw
      361 mtfedvcryf tdiikcrvin tshlsihktw eearlhgawt lhedprqnrg ggcinhkdtf
      421 fqnpqyifev kkpedevlic iqqrpkrstr regkgenlai gfdiykveen rqyrmhslqh
      481 kaassiyins rsvflrtdqp egryviiptt fepghtgefl lrvftdvpsn crelrldepp
      541 htcwsslcgy pqlvtqvhvl gaaglkdspt gansyviikc egdkvrsavq kgtstpeynv
      601 kgifyrkkls qpitvqvwnh rvlkdeflgq vhlkadpdnl qalhtlhlrd rnsrqpsnlp
      661 gtvavhilss tslmav
//
LOCUS       XP_054225783             518 aa            linear   PRI 05-AUG-2025
DEFINITION  tubby protein homolog isoform X2 [Homo sapiens].
ACCESSION   XP_054225783
VERSION     XP_054225783.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369808.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..518
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..518
                     /product="tubby protein homolog isoform X2"
                     /calculated_mol_wt=56591
     Region          41..249
                     /region_name="Tub_N"
                     /note="Tubby N-terminal; pfam16322"
                     /db_xref="CDD:465092"
     Region          268..513
                     /region_name="Tub"
                     /note="Tub family; pfam01167"
                     /db_xref="CDD:460094"
     CDS             1..518
                     /gene="TUB"
                     /gene_synonym="rd5; RDOB"
                     /coded_by="XM_054369808.1:1116..2672"
                     /db_xref="GeneID:7275"
                     /db_xref="HGNC:HGNC:12406"
                     /db_xref="MIM:601197"
ORIGIN      
        1 mepgtgavlt eksccarqts rlghsvldde grnlrqqkld rqralleqkq kkkrqeplmv
       61 qanadgrprs rrarqseeqa plvesylsss gstsyqvqea dslasvqlga trptapasak
      121 rtkaaatagg qggaarkekk gkhkgtsgpa alaedkseaq gpvqiltvgq sdhaqdaget
      181 aagggerpsg qdlratmqrk gisssmsfde deedeeenss sssqlnsntr pssatsrksv
      241 reaasapspt apeqpvdvev qdleefalrp apqgitikcr itrdkkgmdr gmyptyflhl
      301 dredgkkvfl lagrkrkksk tsnylisvdp tdlsrggdsy igklrsnlmg tkftvydngv
      361 npqkassstl esgtlrqela avcyetnvlg fkgprkmsvi vpgmnmvher vsirprnehe
      421 tllarwqnkn tesiielqnk tpvwnddtqs yvlnfhgrvt qasvknfqii hgndpdyivm
      481 qfgrvaedvf tmdynyplca lqafaialss fdsklace
//
LOCUS       XP_054225786             469 aa            linear   PRI 05-AUG-2025
DEFINITION  tubby protein homolog isoform X5 [Homo sapiens].
ACCESSION   XP_054225786
VERSION     XP_054225786.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369811.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..469
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..469
                     /product="tubby protein homolog isoform X5"
                     /calculated_mol_wt=51394
     Region          29..237
                     /region_name="Tub_N"
                     /note="Tubby N-terminal; pfam16322"
                     /db_xref="CDD:465092"
     Region          256..463
                     /region_name="Tub"
                     /note="Tub family; pfam01167"
                     /db_xref="CDD:460094"
     CDS             1..469
                     /gene="TUB"
                     /gene_synonym="rd5; RDOB"
                     /coded_by="XM_054369811.1:301..1710"
                     /db_xref="GeneID:7275"
                     /db_xref="HGNC:HGNC:12406"
                     /db_xref="MIM:601197"
ORIGIN      
        1 mtskphsdwi pysvlddegr nlrqqkldrq ralleqkqkk krqeplmvqa nadgrprsrr
       61 arqseeqapl vesylsssgs tsyqvqeads lasvqlgatr ptapasakrt kaaataggqg
      121 gaarkekkgk hkgtsgpaal aedkseaqgp vqiltvgqsd haqdagetaa gggerpsgqd
      181 lratmqrkgi sssmsfdede edeeenssss sqlnsntrps satsrksvre aasapsptap
      241 eqpvdvevqd leefalrpap qgitikcrit rdkkgmdrgm yptyflhldr edgkkvflla
      301 grkrkkskts nylisvdptd lsrggdsyig klrsnlmgtk ftvydngvnp qkassstles
      361 gtlrqelaav cyetnvlgfk gprkmsvivp gmnmvhervs irprnehetl larwqnknte
      421 siielqnktp vwnddtqsyv lnfhgrvtqa svknfqiihg ndhfpmlna
//
LOCUS       XP_054225789             460 aa            linear   PRI 05-AUG-2025
DEFINITION  tubby protein homolog isoform X8 [Homo sapiens].
ACCESSION   XP_054225789
VERSION     XP_054225789.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369814.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..460
                     /product="tubby protein homolog isoform X8"
                     /calculated_mol_wt=49949
     Region          1..191
                     /region_name="Tub_N"
                     /note="Tubby N-terminal; pfam16322"
                     /db_xref="CDD:465092"
     Region          210..455
                     /region_name="Tub"
                     /note="Tub family; pfam01167"
                     /db_xref="CDD:460094"
     CDS             1..460
                     /gene="TUB"
                     /gene_synonym="rd5; RDOB"
                     /coded_by="XM_054369814.1:203..1585"
                     /db_xref="GeneID:7275"
                     /db_xref="HGNC:HGNC:12406"
                     /db_xref="MIM:601197"
ORIGIN      
        1 mvqanadgrp rsrrarqsee qaplvesyls ssgstsyqvq eadslasvql gatrptapas
       61 akrtkaaata ggqggaarke kkgkhkgtsg paalaedkse aqgpvqiltv gqsdhaqdag
      121 etaagggerp sgqdlratmq rkgisssmsf dedeedeeen sssssqlnsn trpssatsrk
      181 svreaasaps ptapeqpvdv evqdleefal rpapqgitik critrdkkgm drgmyptyfl
      241 hldredgkkv fllagrkrkk sktsnylisv dptdlsrggd syigklrsnl mgtkftvydn
      301 gvnpqkasss tlesgtlrqe laavcyetnv lgfkgprkms vivpgmnmvh ervsirprne
      361 hetllarwqn kntesiielq nktpvwnddt qsyvlnfhgr vtqasvknfq iihgndpdyi
      421 vmqfgrvaed vftmdynypl calqafaial ssfdsklace
//
LOCUS       XP_054225790             471 aa            linear   PRI 05-AUG-2025
DEFINITION  tyrosinase isoform X1 [Homo sapiens].
ACCESSION   XP_054225790
VERSION     XP_054225790.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369815.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 7% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..471
                     /product="tyrosinase isoform X1"
                     /calculated_mol_wt=53632
     Region          171..403
                     /region_name="Tyrosinase"
                     /note="Common central domain of tyrosinase; pfam00264"
                     /db_xref="CDD:425566"
     CDS             1..471
                     /gene="TYR"
                     /gene_synonym="ATN; CMM8; OCA1; OCA1A; OCAIA; SHEP3"
                     /coded_by="XM_054369815.1:80..1495"
                     /db_xref="GeneID:7299"
                     /db_xref="HGNC:HGNC:12442"
                     /db_xref="MIM:606933"
ORIGIN      
        1 mllavlycll wsfqtsaghf pracvssknl mekeccppws gdrspcgqls grgscqnill
       61 snaplgpqfp ftgvddresw psvfynrtcq csgnfmgfnc gnckfgfwgp ncterrllvr
      121 rnifdlsape kdkffayltl akhtissdyv ipigtygqmk ngstpmfndi niydlfvwmh
      181 yyvsmdallg gyeiwrdidf aheapaflpw hrlfllrweq eiqkltgden ftipywdwrd
      241 aekcdictde ymggqhptnp nllspasffs swqivcsrle eynshqslcn gtpegplrrn
      301 pgnhdksrtp rlpssadvef clsltqyesg smdkaanfsf rntlegfasp ltgiadasqs
      361 smhnalhiym ngtmsqvqgs andpifllhh afvdsifeqw lrrhrplqev ypeanapigh
      421 nresymvpfi plyrngdffi sskdlgydys ylqdsvsqwi lfttkatkfp g
//
LOCUS       XP_054225791             543 aa            linear   PRI 05-AUG-2025
DEFINITION  UV radiation resistance-associated gene protein isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225791
VERSION     XP_054225791.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369816.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..543
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..543
                     /product="UV radiation resistance-associated gene protein
                     isoform X1"
                     /calculated_mol_wt=61612
     Region          39..437
                     /region_name="VPS38"
                     /note="Vacuolar protein sorting 38; pfam17649"
                     /db_xref="CDD:435943"
     CDS             1..543
                     /gene="UVRAG"
                     /gene_synonym="DHTX; p63; VPS38"
                     /coded_by="XM_054369816.1:199..1830"
                     /db_xref="GeneID:7405"
                     /db_xref="HGNC:HGNC:12640"
                     /db_xref="MIM:602493"
ORIGIN      
        1 msasasvggp vpqpppgpaa alppgsaara lhvelpsqqr rlrhlrniaa rnivnrnghq
       61 lldtyftlhl cstekiykef yrseviknsl nptwrsldfg impdrldtsv scfvvkiwgg
      121 keniyqllie wkvcldglky lgqqiharnq neiifglndg yygapfehkg ysnaqktill
      181 qvdqncvrns ydvfsllrlh raqcaikqtq vtvqkigkei eeklrltsts nelkkksecl
      241 qlkilvlqne lerqkkalgr evallhkqqi alqdkgsafs aehlklqlqk eslnelrkec
      301 takrelflkt naqltircrq llselsyiyp idlnehkdyf vcgvklpnse dfqakddgsi
      361 avalgytahl vsmisfflqv plrypiihkg srstikdnin dkltekeref plypkggekl
      421 qfdygvylln kniaqlryqh glgtpdlrqt lpnlknfmeh glmvrcikpq mscfqfgakp
      481 swkrqpltgn gwtsalqehs klrkgivata grgtdstths argdsknprq aylqtcvlqn
      541 rhh
//
LOCUS       XP_054225792             462 aa            linear   PRI 05-AUG-2025
DEFINITION  UV radiation resistance-associated gene protein isoform X2 [Homo
            sapiens].
ACCESSION   XP_054225792
VERSION     XP_054225792.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369817.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..462
                     /product="UV radiation resistance-associated gene protein
                     isoform X2"
                     /calculated_mol_wt=52379
     Region          44..>108
                     /region_name="C2"
                     /note="C2 domain; cd00030"
                     /db_xref="CDD:175973"
     Region          184..>395
                     /region_name="ATG14"
                     /note="Vacuolar sorting 38 and autophagy-related subunit
                     14; pfam10186"
                     /db_xref="CDD:462986"
     CDS             1..462
                     /gene="UVRAG"
                     /gene_synonym="DHTX; p63; VPS38"
                     /coded_by="XM_054369817.1:199..1587"
                     /db_xref="GeneID:7405"
                     /db_xref="HGNC:HGNC:12640"
                     /db_xref="MIM:602493"
ORIGIN      
        1 msasasvggp vpqpppgpaa alppgsaara lhvelpsqqr rlrhlrniaa rnivnrnghq
       61 lldtyftlhl cstekiykef yrseviknsl nptwrsldfg impdrldtsv scfvvkiwgg
      121 keniyqllie wkvcldglky lgqqiharnq neiifglndg yygapfehkg ysnaqktill
      181 qvdqncvrns ydvfsllrlh raqcaikqtq vtvqkigkei eeklrltsts nelkkksecl
      241 qlkilvlqne lerqkkalgr evallhkqqi alqdkgsafs aehlklqlqk eslnelrkec
      301 takrelflkt naqltircrq llselsyiyp idlnehkdyf vcgvklpnse dfqakddgsi
      361 avalgytahl vsmisfflqv plrypiihkg srstikdnin dkltekeref plypkggekl
      421 qfdygvylln kniaqmescc vtqagvqwrd lgslqplppg fk
//
LOCUS       XP_054225793             327 aa            linear   PRI 05-AUG-2025
DEFINITION  UV radiation resistance-associated gene protein isoform X3 [Homo
            sapiens].
ACCESSION   XP_054225793
VERSION     XP_054225793.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369818.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..327
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..327
                     /product="UV radiation resistance-associated gene protein
                     isoform X3"
                     /calculated_mol_wt=35857
     CDS             1..327
                     /gene="UVRAG"
                     /gene_synonym="DHTX; p63; VPS38"
                     /coded_by="XM_054369818.1:581..1564"
                     /db_xref="GeneID:7405"
                     /db_xref="HGNC:HGNC:12640"
                     /db_xref="MIM:602493"
ORIGIN      
        1 misfflqvpl rypiihkgsr stikdnindk ltekerefpl ypkggeklqf dygvyllnkn
       61 iaqlryqhgl gtpdlrqtlp nlknfmehgl mvrcdrhhts saipvpkrqs sifggadvgf
      121 sggipspdkg hrkrassene rlqyktppps ynsalaqpvt tvpsmgeter kitslsssld
      181 tsldfskenk kkgedlvgsl ngghanvhps qeqgealsgh ratvngtllp seqagsasvq
      241 lpgefhpvse aelcctveqa eeiigleatg fasgdqleaf ncipvdsava vecdeqvlge
      301 feefsrriya lnenvssfrr prrssdk
//
LOCUS       XP_054225795             304 aa            linear   PRI 05-AUG-2025
DEFINITION  bestrophin-1 isoform X2 [Homo sapiens].
ACCESSION   XP_054225795
VERSION     XP_054225795.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369820.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..304
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..304
                     /product="bestrophin-1 isoform X2"
                     /calculated_mol_wt=34613
     Region          <7..32
                     /region_name="Bestrophin"
                     /note="RFP-TM, chloride channel; cl01544"
                     /db_xref="CDD:470246"
     CDS             1..304
                     /gene="BEST1"
                     /gene_synonym="ARB; BEST; Best1V1Delta2; BMD; RP50; TU15B;
                     VMD2"
                     /coded_by="XM_054369820.1:661..1575"
                     /db_xref="GeneID:7439"
                     /db_xref="HGNC:HGNC:12703"
                     /db_xref="MIM:607854"
ORIGIN      
        1 mnkimqlqva eqlinpfged dddfetnwiv drnlqvslla vdemhqdlpr mepdmywnkp
       61 epqppytaas aqfrrasfmg stfnislnke emefqpnqed eedahagiig rflglqshdh
      121 hppransrtk llwpkresll heglpknhka akqnvrgqed nkawklkavd afksaplyqr
      181 pgyysapqtp lsptpmffpl epsapsklhs vtgidtkdks lktvssgakk sfellsesdg
      241 almehpevsq vrrktvefnl tdmpeipenh lkepleqspt nihttlkdhm dpywalenrd
      301 eahs
//
LOCUS       XP_054225796             270 aa            linear   PRI 05-AUG-2025
DEFINITION  bestrophin-1 isoform X3 [Homo sapiens].
ACCESSION   XP_054225796
VERSION     XP_054225796.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369821.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..270
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..270
                     /product="bestrophin-1 isoform X3"
                     /calculated_mol_wt=31371
     Region          9..>238
                     /region_name="Bestrophin"
                     /note="RFP-TM, chloride channel; pfam01062"
                     /db_xref="CDD:460047"
     CDS             1..270
                     /gene="BEST1"
                     /gene_synonym="ARB; BEST; Best1V1Delta2; BMD; RP50; TU15B;
                     VMD2"
                     /coded_by="XM_054369821.1:644..1456"
                     /db_xref="GeneID:7439"
                     /db_xref="HGNC:HGNC:12703"
                     /db_xref="MIM:607854"
ORIGIN      
        1 mtitytsqva narlgsfsrl llcwrgsiyk llygeflifl lcyyiirfiy rlalteeqql
       61 mfekltlycd syiqlipisf vlgfyvtlvv trwwnqyenl pwpdrlmslv sgfvegkdeq
      121 grllrrtlir yanlgnvlil rsvstavykr fpsaqhlvqa gfmtpaehkq leklslphnm
      181 fwvpwvwfan lsmkawlggr irdpillqsl lnemntlrtq cghlyaydwi siplvytqpe
      241 qrgdgvpaqs ggrggcsrwh hwplprpavp
//
LOCUS       XP_054225799             294 aa            linear   PRI 05-AUG-2025
DEFINITION  metallophosphoesterase MPPED2 isoform X1 [Homo sapiens].
ACCESSION   XP_054225799
VERSION     XP_054225799.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369824.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..294
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..294
                     /product="metallophosphoesterase MPPED2 isoform X1"
                     /calculated_mol_wt=33229
     Region          59..271
                     /region_name="MPP_239FB"
                     /note="Homo sapiens 239FB and related proteins,
                     metallophosphatase domain; cd07379"
                     /db_xref="CDD:277325"
     Site            order(65,67,86,117..118,213,252,254)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:277325"
     Site            order(65,67,86,117,213,252,254)
                     /site_type="other"
                     /note="putative metal binding site [ion binding]"
                     /db_xref="CDD:277325"
     CDS             1..294
                     /gene="MPPED2"
                     /gene_synonym="239FB; C11orf8"
                     /coded_by="XM_054369824.1:1263..2147"
                     /db_xref="GeneID:744"
                     /db_xref="HGNC:HGNC:1180"
                     /db_xref="MIM:600911"
ORIGIN      
        1 mahgipsqgk vtitvdeyss nptqafthyn inqsrfqpph vhmvdpipyd tpkpaghtrf
       61 vcisdthsrt dgiqmpygdi llhtgdftel glpsevkkfn dwlgnlpyey kiviagnhel
      121 tfdkefmadl vkqdyyrfps vsklkpedfd nvqslltnsi ylqdsevtvk gfriygapwt
      181 pwfngwgfnl prgqslldkw nlipegidil mthgpplgfr dwvpkelqrv gcvellntvq
      241 rrvrpklhvf ggihegygim tdgyttyina stctvsfqpt nppiifdlpn pqgs
//
LOCUS       XP_054225800             294 aa            linear   PRI 05-AUG-2025
DEFINITION  metallophosphoesterase MPPED2 isoform X1 [Homo sapiens].
ACCESSION   XP_054225800
VERSION     XP_054225800.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369825.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..294
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..294
                     /product="metallophosphoesterase MPPED2 isoform X1"
                     /calculated_mol_wt=33229
     Region          59..271
                     /region_name="MPP_239FB"
                     /note="Homo sapiens 239FB and related proteins,
                     metallophosphatase domain; cd07379"
                     /db_xref="CDD:277325"
     Site            order(65,67,86,117..118,213,252,254)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:277325"
     Site            order(65,67,86,117,213,252,254)
                     /site_type="other"
                     /note="putative metal binding site [ion binding]"
                     /db_xref="CDD:277325"
     CDS             1..294
                     /gene="MPPED2"
                     /gene_synonym="239FB; C11orf8"
                     /coded_by="XM_054369825.1:143..1027"
                     /db_xref="GeneID:744"
                     /db_xref="HGNC:HGNC:1180"
                     /db_xref="MIM:600911"
ORIGIN      
        1 mahgipsqgk vtitvdeyss nptqafthyn inqsrfqpph vhmvdpipyd tpkpaghtrf
       61 vcisdthsrt dgiqmpygdi llhtgdftel glpsevkkfn dwlgnlpyey kiviagnhel
      121 tfdkefmadl vkqdyyrfps vsklkpedfd nvqslltnsi ylqdsevtvk gfriygapwt
      181 pwfngwgfnl prgqslldkw nlipegidil mthgpplgfr dwvpkelqrv gcvellntvq
      241 rrvrpklhvf ggihegygim tdgyttyina stctvsfqpt nppiifdlpn pqgs
//
LOCUS       XP_054225801             285 aa            linear   PRI 05-AUG-2025
DEFINITION  metallophosphoesterase MPPED2 isoform X2 [Homo sapiens].
ACCESSION   XP_054225801
VERSION     XP_054225801.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369826.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 20% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..285
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..285
                     /product="metallophosphoesterase MPPED2 isoform X2"
                     /calculated_mol_wt=32271
     Region          50..262
                     /region_name="MPP_239FB"
                     /note="Homo sapiens 239FB and related proteins,
                     metallophosphatase domain; cd07379"
                     /db_xref="CDD:277325"
     Site            order(56,58,77,108..109,204,243,245)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:277325"
     Site            order(56,58,77,108,204,243,245)
                     /site_type="other"
                     /note="putative metal binding site [ion binding]"
                     /db_xref="CDD:277325"
     CDS             1..285
                     /gene="MPPED2"
                     /gene_synonym="239FB; C11orf8"
                     /coded_by="XM_054369826.1:481..1338"
                     /db_xref="GeneID:744"
                     /db_xref="HGNC:HGNC:1180"
                     /db_xref="MIM:600911"
ORIGIN      
        1 mrfailysfv igktiinmag rgirmeaiil syflvdpipy dtpkpaghtr fvcisdthsr
       61 tdgiqmpygd illhtgdfte lglpsevkkf ndwlgnlpye ykiviagnhe ltfdkefmad
      121 lvkqdyyrfp svsklkpedf dnvqslltns iylqdsevtv kgfriygapw tpwfngwgfn
      181 lprgqslldk wnlipegidi lmthgpplgf rdwvpkelqr vgcvellntv qrrvrpklhv
      241 fggihegygi mtdgyttyin astctvsfqp tnppiifdlp npqgs
//
LOCUS       XP_054225802             261 aa            linear   PRI 05-AUG-2025
DEFINITION  metallophosphoesterase MPPED2 isoform X4 [Homo sapiens].
ACCESSION   XP_054225802
VERSION     XP_054225802.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369827.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..261
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..261
                     /product="metallophosphoesterase MPPED2 isoform X4"
                     /calculated_mol_wt=29695
     Region          26..238
                     /region_name="MPP_239FB"
                     /note="Homo sapiens 239FB and related proteins,
                     metallophosphatase domain; cd07379"
                     /db_xref="CDD:277325"
     Site            order(32,34,53,84..85,180,219,221)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:277325"
     Site            order(32,34,53,84,180,219,221)
                     /site_type="other"
                     /note="putative metal binding site [ion binding]"
                     /db_xref="CDD:277325"
     CDS             1..261
                     /gene="MPPED2"
                     /gene_synonym="239FB; C11orf8"
                     /coded_by="XM_054369827.1:16..801"
                     /db_xref="GeneID:744"
                     /db_xref="HGNC:HGNC:1180"
                     /db_xref="MIM:600911"
ORIGIN      
        1 mwkqnpyvhm vdpipydtpk paghtrfvci sdthsrtdgi qmpygdillh tgdftelglp
       61 sevkkfndwl gnlpyeykiv iagnheltfd kefmadlvkq dyyrfpsvsk lkpedfdnvq
      121 slltnsiylq dsevtvkgfr iygapwtpwf ngwgfnlprg qslldkwnli pegidilmth
      181 gpplgfrdwv pkelqrvgcv ellntvqrrv rpklhvfggi hegygimtdg yttyinastc
      241 tvsfqptnpp iifdlpnpqg s
//
LOCUS       XP_054225804            1152 aa            linear   PRI 05-AUG-2025
DEFINITION  myelin regulatory factor isoform X1 [Homo sapiens].
ACCESSION   XP_054225804
VERSION     XP_054225804.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369829.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1152
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1152
                     /product="myelin regulatory factor isoform X1"
                     /calculated_mol_wt=124339
     Region          393..540
                     /region_name="NDT80_PhoG"
                     /note="NDT80 / PhoG like DNA-binding family; pfam05224"
                     /db_xref="CDD:398753"
     Region          587..705
                     /region_name="Peptidase_S74_CIMCD"
                     /note="Peptidase S74 family, C-terminal intramolecular
                     chaperone domain of Escherichia coli phage K1F
                     endosialidase and related proteins; cd10144"
                     /db_xref="CDD:381748"
     Site            order(592..599,603,607..608,610,612..617,622,625,629..630,
                     632..639,653..657,661..662,664,666,685..688,690..693,
                     695..699,701..702)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:381748"
     Region          1017..1151
                     /region_name="MRF_C2"
                     /note="Myelin gene regulatory factor C-terminal domain 2;
                     pfam13888"
                     /db_xref="CDD:464020"
     CDS             1..1152
                     /gene="MYRF"
                     /gene_synonym="11orf9; C11orf9; CUGS; MMERV; MRF; Ndt80;
                     NNO1; pqn-47"
                     /coded_by="XM_054369829.1:110..3568"
                     /db_xref="GeneID:745"
                     /db_xref="HGNC:HGNC:1181"
                     /db_xref="MIM:608329"
ORIGIN      
        1 mevvdeteal qrffeghdin galepsnidt sileeyiske dasdlcfpdi sapassasys
       61 hgqpampgss gvhhlsppgg gpspgrhgpl pppgygtpln cnnnngmgaa pkpfpggtgp
      121 pikaepkapy apgtlpdspp dsgseayspq qvnephllrt itpetlchvg vpsrlehppp
      181 ppahlpgppp pppppphypv lqrdlymkae ppiphyaamg qglvptdlhh tqqsqmlhql
      241 lqqhgaelpt hpskkrkhse sppstlnaqm lngmikqepg tvtalplhpt rapsppwppq
      301 gplspgpgsl plsiarvqtp pwhppgapsp gllqdsdsls gsyldpnyqs ikwqphqqnk
      361 watlydanyk elpmltyrvd adkgfnfsvg ddafvcqkkn hfqvtvyigm lgepkyvktp
      421 eglkpldcfy lklhgvklea lnqsinieqs qsdrskrpfn pvtvnlppeq vtkvtvgrlh
      481 fsettannmr kkgkpnpdqr yfmlvvalqa haqnqnytla aqiseriivr asnpgqfesd
      541 sdvlwqraqv pdtvfhhgrv gintdrpdea lvvhgnvkvm gslmhpsdlr akehvqevdt
      601 teqlkrisrm rlvhyrykpe faasagieat apetgviaqe vkeilpeavk dtgdmvfang
      661 ktienflvvn kerifmenvg avkelckltd nletridele rwshklaklr rldslkstgs
      721 sgafshagsq fsragsvphk krppkvasks ssvvpdqaci sqrflqgtii alvvvmafsv
      781 vsmstlyvls lrteedlvdt dgsfavstsc llallrpqpp ggsealcpcr ssqsfgttql
      841 rqsplttglp giqpslllvt tsltssapgs avrtldmcss hpcpviccss pttnpttgps
      901 lgpsfnpghv lspspspstn rsgpsqmall pvtniraksw glsvngighs khhkslepla
      961 spavpfpggq gkaknspslg fhgrarrgal qssvgpaept waqgqsasll aepvpsltsi
     1021 qvlensmsit sqycapgdac rpgnftyhip vssgtplhls ltlqmnsssp vsvvlcslrs
     1081 keepceegsl pqslhthqdt qgtshrwpit ilsfreftyh frvallgqan cssealaqpa
     1141 tdyhfhfyrl cd
//
LOCUS       XP_054225805            1147 aa            linear   PRI 05-AUG-2025
DEFINITION  myelin regulatory factor isoform X2 [Homo sapiens].
ACCESSION   XP_054225805
VERSION     XP_054225805.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369830.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1147
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1147
                     /product="myelin regulatory factor isoform X2"
                     /calculated_mol_wt=123884
     Region          393..540
                     /region_name="NDT80_PhoG"
                     /note="NDT80 / PhoG like DNA-binding family; pfam05224"
                     /db_xref="CDD:398753"
     Region          587..705
                     /region_name="Peptidase_S74_CIMCD"
                     /note="Peptidase S74 family, C-terminal intramolecular
                     chaperone domain of Escherichia coli phage K1F
                     endosialidase and related proteins; cd10144"
                     /db_xref="CDD:381748"
     Site            order(592..599,603,607..608,610,612..617,622,625,629..630,
                     632..639,653..657,661..662,664,666,685..688,690..693,
                     695..699,701..702)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:381748"
     Region          1012..1146
                     /region_name="MRF_C2"
                     /note="Myelin gene regulatory factor C-terminal domain 2;
                     pfam13888"
                     /db_xref="CDD:464020"
     CDS             1..1147
                     /gene="MYRF"
                     /gene_synonym="11orf9; C11orf9; CUGS; MMERV; MRF; Ndt80;
                     NNO1; pqn-47"
                     /coded_by="XM_054369830.1:110..3553"
                     /db_xref="GeneID:745"
                     /db_xref="HGNC:HGNC:1181"
                     /db_xref="MIM:608329"
ORIGIN      
        1 mevvdeteal qrffeghdin galepsnidt sileeyiske dasdlcfpdi sapassasys
       61 hgqpampgss gvhhlsppgg gpspgrhgpl pppgygtpln cnnnngmgaa pkpfpggtgp
      121 pikaepkapy apgtlpdspp dsgseayspq qvnephllrt itpetlchvg vpsrlehppp
      181 ppahlpgppp pppppphypv lqrdlymkae ppiphyaamg qglvptdlhh tqqsqmlhql
      241 lqqhgaelpt hpskkrkhse sppstlnaqm lngmikqepg tvtalplhpt rapsppwppq
      301 gplspgpgsl plsiarvqtp pwhppgapsp gllqdsdsls gsyldpnyqs ikwqphqqnk
      361 watlydanyk elpmltyrvd adkgfnfsvg ddafvcqkkn hfqvtvyigm lgepkyvktp
      421 eglkpldcfy lklhgvklea lnqsinieqs qsdrskrpfn pvtvnlppeq vtkvtvgrlh
      481 fsettannmr kkgkpnpdqr yfmlvvalqa haqnqnytla aqiseriivr asnpgqfesd
      541 sdvlwqraqv pdtvfhhgrv gintdrpdea lvvhgnvkvm gslmhpsdlr akehvqevdt
      601 teqlkrisrm rlvhyrykpe faasagieat apetgviaqe vkeilpeavk dtgdmvfang
      661 ktienflvvn kerifmenvg avkelckltd nletridele rwshklaklr rldslkstgs
      721 sgafshagsq fsragsvphk krppkvasks ssvvpdqaci sqrflqgtii alvvvmafsv
      781 vsmstlyvls lrteedlvdt dgsfavstsc llallrpqpp ggsealcpcr ssqsfgttql
      841 rqsplttglp giqpslllvt tsltssapgs avrtldmcss hpcpviccss pttnpttgps
      901 lgpsfnpghv lspspspstn rsgpsqmall pvtniraksw glsvngighs khhkslepla
      961 spavpfpggq gkaknspslg fhgrarrgal qssvgpaept waqgqsepvp sltsiqvlen
     1021 smsitsqyca pgdacrpgnf tyhipvssgt plhlsltlqm nssspvsvvl cslrskeepc
     1081 eegslpqslh thqdtqgtsh rwpitilsfr eftyhfrval lgqancssea laqpatdyhf
     1141 hfyrlcd
//
LOCUS       XP_054225806            1146 aa            linear   PRI 05-AUG-2025
DEFINITION  myelin regulatory factor isoform X3 [Homo sapiens].
ACCESSION   XP_054225806
VERSION     XP_054225806.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369831.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1146
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1146
                     /product="myelin regulatory factor isoform X3"
                     /calculated_mol_wt=123811
     Region          393..540
                     /region_name="NDT80_PhoG"
                     /note="NDT80 / PhoG like DNA-binding family; pfam05224"
                     /db_xref="CDD:398753"
     Region          587..705
                     /region_name="Peptidase_S74_CIMCD"
                     /note="Peptidase S74 family, C-terminal intramolecular
                     chaperone domain of Escherichia coli phage K1F
                     endosialidase and related proteins; cd10144"
                     /db_xref="CDD:381748"
     Site            order(592..599,603,607..608,610,612..617,622,625,629..630,
                     632..639,653..657,661..662,664,666,685..688,690..693,
                     695..699,701..702)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:381748"
     Region          1011..1145
                     /region_name="MRF_C2"
                     /note="Myelin gene regulatory factor C-terminal domain 2;
                     pfam13888"
                     /db_xref="CDD:464020"
     CDS             1..1146
                     /gene="MYRF"
                     /gene_synonym="11orf9; C11orf9; CUGS; MMERV; MRF; Ndt80;
                     NNO1; pqn-47"
                     /coded_by="XM_054369831.1:110..3550"
                     /db_xref="GeneID:745"
                     /db_xref="HGNC:HGNC:1181"
                     /db_xref="MIM:608329"
ORIGIN      
        1 mevvdeteal qrffeghdin galepsnidt sileeyiske dasdlcfpdi sapassasys
       61 hgqpampgss gvhhlsppgg gpspgrhgpl pppgygtpln cnnnngmgaa pkpfpggtgp
      121 pikaepkapy apgtlpdspp dsgseayspq qvnephllrt itpetlchvg vpsrlehppp
      181 ppahlpgppp pppppphypv lqrdlymkae ppiphyaamg qglvptdlhh tqqsqmlhql
      241 lqqhgaelpt hpskkrkhse sppstlnaqm lngmikqepg tvtalplhpt rapsppwppq
      301 gplspgpgsl plsiarvqtp pwhppgapsp gllqdsdsls gsyldpnyqs ikwqphqqnk
      361 watlydanyk elpmltyrvd adkgfnfsvg ddafvcqkkn hfqvtvyigm lgepkyvktp
      421 eglkpldcfy lklhgvklea lnqsinieqs qsdrskrpfn pvtvnlppeq vtkvtvgrlh
      481 fsettannmr kkgkpnpdqr yfmlvvalqa haqnqnytla aqiseriivr asnpgqfesd
      541 sdvlwqraqv pdtvfhhgrv gintdrpdea lvvhgnvkvm gslmhpsdlr akehvqevdt
      601 teqlkrisrm rlvhyrykpe faasagieat apetgviaqe vkeilpeavk dtgdmvfang
      661 ktienflvvn kerifmenvg avkelckltd nletridele rwshklaklr rldslkstgs
      721 sgafshagsq fsragsvphk krppkvasks ssvvpdqaci sqrflqgtii alvvvmafsv
      781 vsmstlyvls lrteedlvdt dgsfavstsc llallrpqpp ggsealcpws sqsfgttqlr
      841 qsplttglpg iqpslllvtt sltssapgsa vrtldmcssh pcpviccssp ttnpttgpsl
      901 gpsfnpghvl spspspstnr sgpsqmallp vtnirakswg lsvngighsk hhksleplas
      961 pavpfpggqg kaknspslgf hgrarrgalq ssvgpaeptw aqgqsepvps ltsiqvlens
     1021 msitsqycap gdacrpgnft yhipvssgtp lhlsltlqmn ssspvsvvlc slrskeepce
     1081 egslpqslht hqdtqgtshr wpitilsfre ftyhfrvall gqancsseal aqpatdyhfh
     1141 fyrlcd
//
LOCUS       XP_054225807            1125 aa            linear   PRI 05-AUG-2025
DEFINITION  myelin regulatory factor isoform X4 [Homo sapiens].
ACCESSION   XP_054225807
VERSION     XP_054225807.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369832.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1125
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1125
                     /product="myelin regulatory factor isoform X4"
                     /calculated_mol_wt=121639
     Region          393..540
                     /region_name="NDT80_PhoG"
                     /note="NDT80 / PhoG like DNA-binding family; pfam05224"
                     /db_xref="CDD:398753"
     Region          587..705
                     /region_name="Peptidase_S74_CIMCD"
                     /note="Peptidase S74 family, C-terminal intramolecular
                     chaperone domain of Escherichia coli phage K1F
                     endosialidase and related proteins; cd10144"
                     /db_xref="CDD:381748"
     Site            order(592..599,603,607..608,610,612..617,622,625,629..630,
                     632..639,653..657,661..662,664,666,685..688,690..693,
                     695..699,701..702)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:381748"
     Region          990..1124
                     /region_name="MRF_C2"
                     /note="Myelin gene regulatory factor C-terminal domain 2;
                     pfam13888"
                     /db_xref="CDD:464020"
     CDS             1..1125
                     /gene="MYRF"
                     /gene_synonym="11orf9; C11orf9; CUGS; MMERV; MRF; Ndt80;
                     NNO1; pqn-47"
                     /coded_by="XM_054369832.1:110..3487"
                     /db_xref="GeneID:745"
                     /db_xref="HGNC:HGNC:1181"
                     /db_xref="MIM:608329"
ORIGIN      
        1 mevvdeteal qrffeghdin galepsnidt sileeyiske dasdlcfpdi sapassasys
       61 hgqpampgss gvhhlsppgg gpspgrhgpl pppgygtpln cnnnngmgaa pkpfpggtgp
      121 pikaepkapy apgtlpdspp dsgseayspq qvnephllrt itpetlchvg vpsrlehppp
      181 ppahlpgppp pppppphypv lqrdlymkae ppiphyaamg qglvptdlhh tqqsqmlhql
      241 lqqhgaelpt hpskkrkhse sppstlnaqm lngmikqepg tvtalplhpt rapsppwppq
      301 gplspgpgsl plsiarvqtp pwhppgapsp gllqdsdsls gsyldpnyqs ikwqphqqnk
      361 watlydanyk elpmltyrvd adkgfnfsvg ddafvcqkkn hfqvtvyigm lgepkyvktp
      421 eglkpldcfy lklhgvklea lnqsinieqs qsdrskrpfn pvtvnlppeq vtkvtvgrlh
      481 fsettannmr kkgkpnpdqr yfmlvvalqa haqnqnytla aqiseriivr asnpgqfesd
      541 sdvlwqraqv pdtvfhhgrv gintdrpdea lvvhgnvkvm gslmhpsdlr akehvqevdt
      601 teqlkrisrm rlvhyrykpe faasagieat apetgviaqe vkeilpeavk dtgdmvfang
      661 ktienflvvn kerifmenvg avkelckltd nletridele rwshklaklr rldslkstgs
      721 sgafshagsq fsragsvphk krppkvasks ssvvpdqaci sqrflqgtii alvvvmafsv
      781 vsmstlyvls lrteedlvdt dgrssqsfgt tqlrqspltt glpgiqpsll lvttsltssa
      841 pgsavrtldm csshpcpvic csspttnptt gpslgpsfnp ghvlspspsp stnrsgpsqm
      901 allpvtnira kswglsvngi ghskhhksle plaspavpfp ggqgkaknsp slgfhgrarr
      961 galqssvgpa eptwaqgqsa sllaepvpsl tsiqvlensm sitsqycapg dacrpgnfty
     1021 hipvssgtpl hlsltlqmns sspvsvvlcs lrskeepcee gslpqslhth qdtqgtshrw
     1081 pitilsfref tyhfrvallg qancsseala qpatdyhfhf yrlcd
//
LOCUS       XP_054225808            1124 aa            linear   PRI 05-AUG-2025
DEFINITION  myelin regulatory factor isoform X5 [Homo sapiens].
ACCESSION   XP_054225808
VERSION     XP_054225808.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369833.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1124
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1124
                     /product="myelin regulatory factor isoform X5"
                     /calculated_mol_wt=121483
     Region          393..540
                     /region_name="NDT80_PhoG"
                     /note="NDT80 / PhoG like DNA-binding family; pfam05224"
                     /db_xref="CDD:398753"
     Region          587..705
                     /region_name="Peptidase_S74_CIMCD"
                     /note="Peptidase S74 family, C-terminal intramolecular
                     chaperone domain of Escherichia coli phage K1F
                     endosialidase and related proteins; cd10144"
                     /db_xref="CDD:381748"
     Site            order(592..599,603,607..608,610,612..617,622,625,629..630,
                     632..639,653..657,661..662,664,666,685..688,690..693,
                     695..699,701..702)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:381748"
     Region          989..1123
                     /region_name="MRF_C2"
                     /note="Myelin gene regulatory factor C-terminal domain 2;
                     pfam13888"
                     /db_xref="CDD:464020"
     CDS             1..1124
                     /gene="MYRF"
                     /gene_synonym="11orf9; C11orf9; CUGS; MMERV; MRF; Ndt80;
                     NNO1; pqn-47"
                     /coded_by="XM_054369833.1:110..3484"
                     /db_xref="GeneID:745"
                     /db_xref="HGNC:HGNC:1181"
                     /db_xref="MIM:608329"
ORIGIN      
        1 mevvdeteal qrffeghdin galepsnidt sileeyiske dasdlcfpdi sapassasys
       61 hgqpampgss gvhhlsppgg gpspgrhgpl pppgygtpln cnnnngmgaa pkpfpggtgp
      121 pikaepkapy apgtlpdspp dsgseayspq qvnephllrt itpetlchvg vpsrlehppp
      181 ppahlpgppp pppppphypv lqrdlymkae ppiphyaamg qglvptdlhh tqqsqmlhql
      241 lqqhgaelpt hpskkrkhse sppstlnaqm lngmikqepg tvtalplhpt rapsppwppq
      301 gplspgpgsl plsiarvqtp pwhppgapsp gllqdsdsls gsyldpnyqs ikwqphqqnk
      361 watlydanyk elpmltyrvd adkgfnfsvg ddafvcqkkn hfqvtvyigm lgepkyvktp
      421 eglkpldcfy lklhgvklea lnqsinieqs qsdrskrpfn pvtvnlppeq vtkvtvgrlh
      481 fsettannmr kkgkpnpdqr yfmlvvalqa haqnqnytla aqiseriivr asnpgqfesd
      541 sdvlwqraqv pdtvfhhgrv gintdrpdea lvvhgnvkvm gslmhpsdlr akehvqevdt
      601 teqlkrisrm rlvhyrykpe faasagieat apetgviaqe vkeilpeavk dtgdmvfang
      661 ktienflvvn kerifmenvg avkelckltd nletridele rwshklaklr rldslkstgs
      721 sgafshagsq fsragsvphk krppkvasks ssvvpdqaci sqrflqgtii alvvvmafsv
      781 vsmstlyvls lrteedlvdt dgssqsfgtt qlrqsplttg lpgiqpslll vttsltssap
      841 gsavrtldmc sshpcpvicc sspttnpttg pslgpsfnpg hvlspspsps tnrsgpsqma
      901 llpvtnirak swglsvngig hskhhkslep laspavpfpg gqgkaknsps lgfhgrarrg
      961 alqssvgpae ptwaqgqsas llaepvpslt siqvlensms itsqycapgd acrpgnftyh
     1021 ipvssgtplh lsltlqmnss spvsvvlcsl rskeepceeg slpqslhthq dtqgtshrwp
     1081 itilsfreft yhfrvallgq ancssealaq patdyhfhfy rlcd
//
LOCUS       XP_054225809            1120 aa            linear   PRI 05-AUG-2025
DEFINITION  myelin regulatory factor isoform X6 [Homo sapiens].
ACCESSION   XP_054225809
VERSION     XP_054225809.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369834.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1120
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1120
                     /product="myelin regulatory factor isoform X6"
                     /calculated_mol_wt=121184
     Region          393..540
                     /region_name="NDT80_PhoG"
                     /note="NDT80 / PhoG like DNA-binding family; pfam05224"
                     /db_xref="CDD:398753"
     Region          587..705
                     /region_name="Peptidase_S74_CIMCD"
                     /note="Peptidase S74 family, C-terminal intramolecular
                     chaperone domain of Escherichia coli phage K1F
                     endosialidase and related proteins; cd10144"
                     /db_xref="CDD:381748"
     Site            order(592..599,603,607..608,610,612..617,622,625,629..630,
                     632..639,653..657,661..662,664,666,685..688,690..693,
                     695..699,701..702)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:381748"
     Region          985..1119
                     /region_name="MRF_C2"
                     /note="Myelin gene regulatory factor C-terminal domain 2;
                     pfam13888"
                     /db_xref="CDD:464020"
     CDS             1..1120
                     /gene="MYRF"
                     /gene_synonym="11orf9; C11orf9; CUGS; MMERV; MRF; Ndt80;
                     NNO1; pqn-47"
                     /coded_by="XM_054369834.1:110..3472"
                     /db_xref="GeneID:745"
                     /db_xref="HGNC:HGNC:1181"
                     /db_xref="MIM:608329"
ORIGIN      
        1 mevvdeteal qrffeghdin galepsnidt sileeyiske dasdlcfpdi sapassasys
       61 hgqpampgss gvhhlsppgg gpspgrhgpl pppgygtpln cnnnngmgaa pkpfpggtgp
      121 pikaepkapy apgtlpdspp dsgseayspq qvnephllrt itpetlchvg vpsrlehppp
      181 ppahlpgppp pppppphypv lqrdlymkae ppiphyaamg qglvptdlhh tqqsqmlhql
      241 lqqhgaelpt hpskkrkhse sppstlnaqm lngmikqepg tvtalplhpt rapsppwppq
      301 gplspgpgsl plsiarvqtp pwhppgapsp gllqdsdsls gsyldpnyqs ikwqphqqnk
      361 watlydanyk elpmltyrvd adkgfnfsvg ddafvcqkkn hfqvtvyigm lgepkyvktp
      421 eglkpldcfy lklhgvklea lnqsinieqs qsdrskrpfn pvtvnlppeq vtkvtvgrlh
      481 fsettannmr kkgkpnpdqr yfmlvvalqa haqnqnytla aqiseriivr asnpgqfesd
      541 sdvlwqraqv pdtvfhhgrv gintdrpdea lvvhgnvkvm gslmhpsdlr akehvqevdt
      601 teqlkrisrm rlvhyrykpe faasagieat apetgviaqe vkeilpeavk dtgdmvfang
      661 ktienflvvn kerifmenvg avkelckltd nletridele rwshklaklr rldslkstgs
      721 sgafshagsq fsragsvphk krppkvasks ssvvpdqaci sqrflqgtii alvvvmafsv
      781 vsmstlyvls lrteedlvdt dgrssqsfgt tqlrqspltt glpgiqpsll lvttsltssa
      841 pgsavrtldm csshpcpvic csspttnptt gpslgpsfnp ghvlspspsp stnrsgpsqm
      901 allpvtnira kswglsvngi ghskhhksle plaspavpfp ggqgkaknsp slgfhgrarr
      961 galqssvgpa eptwaqgqse pvpsltsiqv lensmsitsq ycapgdacrp gnftyhipvs
     1021 sgtplhlslt lqmnssspvs vvlcslrske epceegslpq slhthqdtqg tshrwpitil
     1081 sfreftyhfr vallgqancs sealaqpatd yhfhfyrlcd
//
LOCUS       XP_054225810            1119 aa            linear   PRI 05-AUG-2025
DEFINITION  myelin regulatory factor isoform X7 [Homo sapiens].
ACCESSION   XP_054225810
VERSION     XP_054225810.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369835.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1119
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1119
                     /product="myelin regulatory factor isoform X7"
                     /calculated_mol_wt=121027
     Region          393..540
                     /region_name="NDT80_PhoG"
                     /note="NDT80 / PhoG like DNA-binding family; pfam05224"
                     /db_xref="CDD:398753"
     Region          587..705
                     /region_name="Peptidase_S74_CIMCD"
                     /note="Peptidase S74 family, C-terminal intramolecular
                     chaperone domain of Escherichia coli phage K1F
                     endosialidase and related proteins; cd10144"
                     /db_xref="CDD:381748"
     Site            order(592..599,603,607..608,610,612..617,622,625,629..630,
                     632..639,653..657,661..662,664,666,685..688,690..693,
                     695..699,701..702)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:381748"
     Region          984..1118
                     /region_name="MRF_C2"
                     /note="Myelin gene regulatory factor C-terminal domain 2;
                     pfam13888"
                     /db_xref="CDD:464020"
     CDS             1..1119
                     /gene="MYRF"
                     /gene_synonym="11orf9; C11orf9; CUGS; MMERV; MRF; Ndt80;
                     NNO1; pqn-47"
                     /coded_by="XM_054369835.1:110..3469"
                     /db_xref="GeneID:745"
                     /db_xref="HGNC:HGNC:1181"
                     /db_xref="MIM:608329"
ORIGIN      
        1 mevvdeteal qrffeghdin galepsnidt sileeyiske dasdlcfpdi sapassasys
       61 hgqpampgss gvhhlsppgg gpspgrhgpl pppgygtpln cnnnngmgaa pkpfpggtgp
      121 pikaepkapy apgtlpdspp dsgseayspq qvnephllrt itpetlchvg vpsrlehppp
      181 ppahlpgppp pppppphypv lqrdlymkae ppiphyaamg qglvptdlhh tqqsqmlhql
      241 lqqhgaelpt hpskkrkhse sppstlnaqm lngmikqepg tvtalplhpt rapsppwppq
      301 gplspgpgsl plsiarvqtp pwhppgapsp gllqdsdsls gsyldpnyqs ikwqphqqnk
      361 watlydanyk elpmltyrvd adkgfnfsvg ddafvcqkkn hfqvtvyigm lgepkyvktp
      421 eglkpldcfy lklhgvklea lnqsinieqs qsdrskrpfn pvtvnlppeq vtkvtvgrlh
      481 fsettannmr kkgkpnpdqr yfmlvvalqa haqnqnytla aqiseriivr asnpgqfesd
      541 sdvlwqraqv pdtvfhhgrv gintdrpdea lvvhgnvkvm gslmhpsdlr akehvqevdt
      601 teqlkrisrm rlvhyrykpe faasagieat apetgviaqe vkeilpeavk dtgdmvfang
      661 ktienflvvn kerifmenvg avkelckltd nletridele rwshklaklr rldslkstgs
      721 sgafshagsq fsragsvphk krppkvasks ssvvpdqaci sqrflqgtii alvvvmafsv
      781 vsmstlyvls lrteedlvdt dgssqsfgtt qlrqsplttg lpgiqpslll vttsltssap
      841 gsavrtldmc sshpcpvicc sspttnpttg pslgpsfnpg hvlspspsps tnrsgpsqma
      901 llpvtnirak swglsvngig hskhhkslep laspavpfpg gqgkaknsps lgfhgrarrg
      961 alqssvgpae ptwaqgqsep vpsltsiqvl ensmsitsqy capgdacrpg nftyhipvss
     1021 gtplhlsltl qmnssspvsv vlcslrskee pceegslpqs lhthqdtqgt shrwpitils
     1081 freftyhfrv allgqancss ealaqpatdy hfhfyrlcd
//
LOCUS       XP_054225811            1101 aa            linear   PRI 05-AUG-2025
DEFINITION  myelin regulatory factor isoform X8 [Homo sapiens].
ACCESSION   XP_054225811
VERSION     XP_054225811.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369836.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1101
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1101
                     /product="myelin regulatory factor isoform X8"
                     /calculated_mol_wt=118836
     Region          342..489
                     /region_name="NDT80_PhoG"
                     /note="NDT80 / PhoG like DNA-binding family; pfam05224"
                     /db_xref="CDD:398753"
     Region          536..654
                     /region_name="Peptidase_S74_CIMCD"
                     /note="Peptidase S74 family, C-terminal intramolecular
                     chaperone domain of Escherichia coli phage K1F
                     endosialidase and related proteins; cd10144"
                     /db_xref="CDD:381748"
     Site            order(541..548,552,556..557,559,561..566,571,574,578..579,
                     581..588,602..606,610..611,613,615,634..637,639..642,
                     644..648,650..651)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:381748"
     Region          966..1100
                     /region_name="MRF_C2"
                     /note="Myelin gene regulatory factor C-terminal domain 2;
                     pfam13888"
                     /db_xref="CDD:464020"
     CDS             1..1101
                     /gene="MYRF"
                     /gene_synonym="11orf9; C11orf9; CUGS; MMERV; MRF; Ndt80;
                     NNO1; pqn-47"
                     /coded_by="XM_054369836.1:110..3415"
                     /db_xref="GeneID:745"
                     /db_xref="HGNC:HGNC:1181"
                     /db_xref="MIM:608329"
ORIGIN      
        1 mevvdeteal qrffeghdin galepsnidt sileeyiske dasdlcfpdi sapassasys
       61 hgqpampgss gvhhlsppgg gpspgrhgpl pppgygtpln cnnnngmgaa pkpfpggtgp
      121 pikaepkapy apgtlpdspp dsgseayspq qrdlymkaep piphyaamgq glvptdlhht
      181 qqsqmlhqll qqhgaelpth pskkrkhses ppstlnaqml ngmikqepgt vtalplhptr
      241 apsppwppqg plspgpgslp lsiarvqtpp whppgapspg llqdsdslsg syldpnyqsi
      301 kwqphqqnkw atlydanyke lpmltyrvda dkgfnfsvgd dafvcqkknh fqvtvyigml
      361 gepkyvktpe glkpldcfyl klhgvkleal nqsinieqsq sdrskrpfnp vtvnlppeqv
      421 tkvtvgrlhf settannmrk kgkpnpdqry fmlvvalqah aqnqnytlaa qiseriivra
      481 snpgqfesds dvlwqraqvp dtvfhhgrvg intdrpdeal vvhgnvkvmg slmhpsdlra
      541 kehvqevdtt eqlkrisrmr lvhyrykpef aasagieata petgviaqev keilpeavkd
      601 tgdmvfangk tienflvvnk erifmenvga vkelckltdn letrideler wshklaklrr
      661 ldslkstgss gafshagsqf sragsvphkk rppkvaskss svvpdqacis qrflqgtiia
      721 lvvvmafsvv smstlyvlsl rteedlvdtd gsfavstscl lallrpqppg gsealcpcrs
      781 sqsfgttqlr qsplttglpg iqpslllvtt sltssapgsa vrtldmcssh pcpviccssp
      841 ttnpttgpsl gpsfnpghvl spspspstnr sgpsqmallp vtnirakswg lsvngighsk
      901 hhksleplas pavpfpggqg kaknspslgf hgrarrgalq ssvgpaeptw aqgqsaslla
      961 epvpsltsiq vlensmsits qycapgdacr pgnftyhipv ssgtplhlsl tlqmnssspv
     1021 svvlcslrsk eepceegslp qslhthqdtq gtshrwpiti lsfreftyhf rvallgqanc
     1081 ssealaqpat dyhfhfyrlc d
//
LOCUS       XP_054225812            1100 aa            linear   PRI 05-AUG-2025
DEFINITION  myelin regulatory factor isoform X9 [Homo sapiens].
ACCESSION   XP_054225812
VERSION     XP_054225812.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369837.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1100
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1100
                     /product="myelin regulatory factor isoform X9"
                     /calculated_mol_wt=118763
     Region          342..489
                     /region_name="NDT80_PhoG"
                     /note="NDT80 / PhoG like DNA-binding family; pfam05224"
                     /db_xref="CDD:398753"
     Region          536..654
                     /region_name="Peptidase_S74_CIMCD"
                     /note="Peptidase S74 family, C-terminal intramolecular
                     chaperone domain of Escherichia coli phage K1F
                     endosialidase and related proteins; cd10144"
                     /db_xref="CDD:381748"
     Site            order(541..548,552,556..557,559,561..566,571,574,578..579,
                     581..588,602..606,610..611,613,615,634..637,639..642,
                     644..648,650..651)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:381748"
     Region          965..1099
                     /region_name="MRF_C2"
                     /note="Myelin gene regulatory factor C-terminal domain 2;
                     pfam13888"
                     /db_xref="CDD:464020"
     CDS             1..1100
                     /gene="MYRF"
                     /gene_synonym="11orf9; C11orf9; CUGS; MMERV; MRF; Ndt80;
                     NNO1; pqn-47"
                     /coded_by="XM_054369837.1:110..3412"
                     /db_xref="GeneID:745"
                     /db_xref="HGNC:HGNC:1181"
                     /db_xref="MIM:608329"
ORIGIN      
        1 mevvdeteal qrffeghdin galepsnidt sileeyiske dasdlcfpdi sapassasys
       61 hgqpampgss gvhhlsppgg gpspgrhgpl pppgygtpln cnnnngmgaa pkpfpggtgp
      121 pikaepkapy apgtlpdspp dsgseayspq qrdlymkaep piphyaamgq glvptdlhht
      181 qqsqmlhqll qqhgaelpth pskkrkhses ppstlnaqml ngmikqepgt vtalplhptr
      241 apsppwppqg plspgpgslp lsiarvqtpp whppgapspg llqdsdslsg syldpnyqsi
      301 kwqphqqnkw atlydanyke lpmltyrvda dkgfnfsvgd dafvcqkknh fqvtvyigml
      361 gepkyvktpe glkpldcfyl klhgvkleal nqsinieqsq sdrskrpfnp vtvnlppeqv
      421 tkvtvgrlhf settannmrk kgkpnpdqry fmlvvalqah aqnqnytlaa qiseriivra
      481 snpgqfesds dvlwqraqvp dtvfhhgrvg intdrpdeal vvhgnvkvmg slmhpsdlra
      541 kehvqevdtt eqlkrisrmr lvhyrykpef aasagieata petgviaqev keilpeavkd
      601 tgdmvfangk tienflvvnk erifmenvga vkelckltdn letrideler wshklaklrr
      661 ldslkstgss gafshagsqf sragsvphkk rppkvaskss svvpdqacis qrflqgtiia
      721 lvvvmafsvv smstlyvlsl rteedlvdtd gsfavstscl lallrpqppg gsealcpwss
      781 qsfgttqlrq splttglpgi qpslllvtts ltssapgsav rtldmcsshp cpviccsspt
      841 tnpttgpslg psfnpghvls pspspstnrs gpsqmallpv tnirakswgl svngighskh
      901 hksleplasp avpfpggqgk aknspslgfh grarrgalqs svgpaeptwa qgqsasllae
      961 pvpsltsiqv lensmsitsq ycapgdacrp gnftyhipvs sgtplhlslt lqmnssspvs
     1021 vvlcslrske epceegslpq slhthqdtqg tshrwpitil sfreftyhfr vallgqancs
     1081 sealaqpatd yhfhfyrlcd
//
LOCUS       XP_054225813            1096 aa            linear   PRI 05-AUG-2025
DEFINITION  myelin regulatory factor isoform X10 [Homo sapiens].
ACCESSION   XP_054225813
VERSION     XP_054225813.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369838.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1096
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1096
                     /product="myelin regulatory factor isoform X10"
                     /calculated_mol_wt=118380
     Region          342..489
                     /region_name="NDT80_PhoG"
                     /note="NDT80 / PhoG like DNA-binding family; pfam05224"
                     /db_xref="CDD:398753"
     Region          536..654
                     /region_name="Peptidase_S74_CIMCD"
                     /note="Peptidase S74 family, C-terminal intramolecular
                     chaperone domain of Escherichia coli phage K1F
                     endosialidase and related proteins; cd10144"
                     /db_xref="CDD:381748"
     Site            order(541..548,552,556..557,559,561..566,571,574,578..579,
                     581..588,602..606,610..611,613,615,634..637,639..642,
                     644..648,650..651)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:381748"
     Region          961..1095
                     /region_name="MRF_C2"
                     /note="Myelin gene regulatory factor C-terminal domain 2;
                     pfam13888"
                     /db_xref="CDD:464020"
     CDS             1..1096
                     /gene="MYRF"
                     /gene_synonym="11orf9; C11orf9; CUGS; MMERV; MRF; Ndt80;
                     NNO1; pqn-47"
                     /coded_by="XM_054369838.1:110..3400"
                     /db_xref="GeneID:745"
                     /db_xref="HGNC:HGNC:1181"
                     /db_xref="MIM:608329"
ORIGIN      
        1 mevvdeteal qrffeghdin galepsnidt sileeyiske dasdlcfpdi sapassasys
       61 hgqpampgss gvhhlsppgg gpspgrhgpl pppgygtpln cnnnngmgaa pkpfpggtgp
      121 pikaepkapy apgtlpdspp dsgseayspq qrdlymkaep piphyaamgq glvptdlhht
      181 qqsqmlhqll qqhgaelpth pskkrkhses ppstlnaqml ngmikqepgt vtalplhptr
      241 apsppwppqg plspgpgslp lsiarvqtpp whppgapspg llqdsdslsg syldpnyqsi
      301 kwqphqqnkw atlydanyke lpmltyrvda dkgfnfsvgd dafvcqkknh fqvtvyigml
      361 gepkyvktpe glkpldcfyl klhgvkleal nqsinieqsq sdrskrpfnp vtvnlppeqv
      421 tkvtvgrlhf settannmrk kgkpnpdqry fmlvvalqah aqnqnytlaa qiseriivra
      481 snpgqfesds dvlwqraqvp dtvfhhgrvg intdrpdeal vvhgnvkvmg slmhpsdlra
      541 kehvqevdtt eqlkrisrmr lvhyrykpef aasagieata petgviaqev keilpeavkd
      601 tgdmvfangk tienflvvnk erifmenvga vkelckltdn letrideler wshklaklrr
      661 ldslkstgss gafshagsqf sragsvphkk rppkvaskss svvpdqacis qrflqgtiia
      721 lvvvmafsvv smstlyvlsl rteedlvdtd gsfavstscl lallrpqppg gsealcpcrs
      781 sqsfgttqlr qsplttglpg iqpslllvtt sltssapgsa vrtldmcssh pcpviccssp
      841 ttnpttgpsl gpsfnpghvl spspspstnr sgpsqmallp vtnirakswg lsvngighsk
      901 hhksleplas pavpfpggqg kaknspslgf hgrarrgalq ssvgpaeptw aqgqsepvps
      961 ltsiqvlens msitsqycap gdacrpgnft yhipvssgtp lhlsltlqmn ssspvsvvlc
     1021 slrskeepce egslpqslht hqdtqgtshr wpitilsfre ftyhfrvall gqancsseal
     1081 aqpatdyhfh fyrlcd
//
LOCUS       XP_054225814            1095 aa            linear   PRI 05-AUG-2025
DEFINITION  myelin regulatory factor isoform X11 [Homo sapiens].
ACCESSION   XP_054225814
VERSION     XP_054225814.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369839.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1095
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1095
                     /product="myelin regulatory factor isoform X11"
                     /calculated_mol_wt=118307
     Region          342..489
                     /region_name="NDT80_PhoG"
                     /note="NDT80 / PhoG like DNA-binding family; pfam05224"
                     /db_xref="CDD:398753"
     Region          536..654
                     /region_name="Peptidase_S74_CIMCD"
                     /note="Peptidase S74 family, C-terminal intramolecular
                     chaperone domain of Escherichia coli phage K1F
                     endosialidase and related proteins; cd10144"
                     /db_xref="CDD:381748"
     Site            order(541..548,552,556..557,559,561..566,571,574,578..579,
                     581..588,602..606,610..611,613,615,634..637,639..642,
                     644..648,650..651)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:381748"
     Region          960..1094
                     /region_name="MRF_C2"
                     /note="Myelin gene regulatory factor C-terminal domain 2;
                     pfam13888"
                     /db_xref="CDD:464020"
     CDS             1..1095
                     /gene="MYRF"
                     /gene_synonym="11orf9; C11orf9; CUGS; MMERV; MRF; Ndt80;
                     NNO1; pqn-47"
                     /coded_by="XM_054369839.1:110..3397"
                     /db_xref="GeneID:745"
                     /db_xref="HGNC:HGNC:1181"
                     /db_xref="MIM:608329"
ORIGIN      
        1 mevvdeteal qrffeghdin galepsnidt sileeyiske dasdlcfpdi sapassasys
       61 hgqpampgss gvhhlsppgg gpspgrhgpl pppgygtpln cnnnngmgaa pkpfpggtgp
      121 pikaepkapy apgtlpdspp dsgseayspq qrdlymkaep piphyaamgq glvptdlhht
      181 qqsqmlhqll qqhgaelpth pskkrkhses ppstlnaqml ngmikqepgt vtalplhptr
      241 apsppwppqg plspgpgslp lsiarvqtpp whppgapspg llqdsdslsg syldpnyqsi
      301 kwqphqqnkw atlydanyke lpmltyrvda dkgfnfsvgd dafvcqkknh fqvtvyigml
      361 gepkyvktpe glkpldcfyl klhgvkleal nqsinieqsq sdrskrpfnp vtvnlppeqv
      421 tkvtvgrlhf settannmrk kgkpnpdqry fmlvvalqah aqnqnytlaa qiseriivra
      481 snpgqfesds dvlwqraqvp dtvfhhgrvg intdrpdeal vvhgnvkvmg slmhpsdlra
      541 kehvqevdtt eqlkrisrmr lvhyrykpef aasagieata petgviaqev keilpeavkd
      601 tgdmvfangk tienflvvnk erifmenvga vkelckltdn letrideler wshklaklrr
      661 ldslkstgss gafshagsqf sragsvphkk rppkvaskss svvpdqacis qrflqgtiia
      721 lvvvmafsvv smstlyvlsl rteedlvdtd gsfavstscl lallrpqppg gsealcpwss
      781 qsfgttqlrq splttglpgi qpslllvtts ltssapgsav rtldmcsshp cpviccsspt
      841 tnpttgpslg psfnpghvls pspspstnrs gpsqmallpv tnirakswgl svngighskh
      901 hksleplasp avpfpggqgk aknspslgfh grarrgalqs svgpaeptwa qgqsepvpsl
      961 tsiqvlensm sitsqycapg dacrpgnfty hipvssgtpl hlsltlqmns sspvsvvlcs
     1021 lrskeepcee gslpqslhth qdtqgtshrw pitilsfref tyhfrvallg qancsseala
     1081 qpatdyhfhf yrlcd
//
LOCUS       XP_054225815            1081 aa            linear   PRI 05-AUG-2025
DEFINITION  myelin regulatory factor isoform X12 [Homo sapiens].
ACCESSION   XP_054225815
VERSION     XP_054225815.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369840.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1081
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1081
                     /product="myelin regulatory factor isoform X12"
                     /calculated_mol_wt=116782
     Region          328..475
                     /region_name="NDT80_PhoG"
                     /note="NDT80 / PhoG like DNA-binding family; pfam05224"
                     /db_xref="CDD:398753"
     Region          522..640
                     /region_name="Peptidase_S74_CIMCD"
                     /note="Peptidase S74 family, C-terminal intramolecular
                     chaperone domain of Escherichia coli phage K1F
                     endosialidase and related proteins; cd10144"
                     /db_xref="CDD:381748"
     Site            order(527..534,538,542..543,545,547..552,557,560,564..565,
                     567..574,588..592,596..597,599,601,620..623,625..628,
                     630..634,636..637)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:381748"
     Region          946..1080
                     /region_name="MRF_C2"
                     /note="Myelin gene regulatory factor C-terminal domain 2;
                     pfam13888"
                     /db_xref="CDD:464020"
     CDS             1..1081
                     /gene="MYRF"
                     /gene_synonym="11orf9; C11orf9; CUGS; MMERV; MRF; Ndt80;
                     NNO1; pqn-47"
                     /coded_by="XM_054369840.1:641..3886"
                     /db_xref="GeneID:745"
                     /db_xref="HGNC:HGNC:1181"
                     /db_xref="MIM:608329"
ORIGIN      
        1 mpgssgvhhl sppgggpspg rhgplpppgy gtplncnnnn gmgaapkpfp ggtgppikae
       61 pkapyapgtl pdsppdsgse ayspqqvnep hllrtitpet lchvgvpsrl ehpppppahl
      121 pgpppppppp phypvlqrdl ymkaeppiph yaamgqglvp tdlhhtqqsq mlhqllqqhg
      181 aelpthpskk rkhsesppst lnaqmlngmi kqepgtvtal plhptrapsp pwppqgplsp
      241 gpgslplsia rvqtppwhpp gapspgllqd sdslsgsyld pnyqsikwqp hqqnkwatly
      301 danykelpml tyrvdadkgf nfsvgddafv cqkknhfqvt vyigmlgepk yvktpeglkp
      361 ldcfylklhg vklealnqsi nieqsqsdrs krpfnpvtvn lppeqvtkvt vgrlhfsett
      421 annmrkkgkp npdqryfmlv valqahaqnq nytlaaqise riivrasnpg qfesdsdvlw
      481 qraqvpdtvf hhgrvgintd rpdealvvhg nvkvmgslmh psdlrakehv qevdtteqlk
      541 risrmrlvhy rykpefaasa gieatapetg viaqevkeil peavkdtgdm vfangktien
      601 flvvnkerif menvgavkel ckltdnletr idelerwshk laklrrldsl kstgssgafs
      661 hagsqfsrag svphkkrppk vasksssvvp dqacisqrfl qgtiialvvv mafsvvsmst
      721 lyvlslrtee dlvdtdgsfa vstscllall rpqppggsea lcpwssqsfg ttqlrqsplt
      781 tglpgiqpsl llvttsltss apgsavrtld mcsshpcpvi ccsspttnpt tgpslgpsfn
      841 pghvlspsps pstnrsgpsq mallpvtnir akswglsvng ighskhhksl eplaspavpf
      901 pggqgkakns pslgfhgrar rgalqssvgp aeptwaqgqs epvpsltsiq vlensmsits
      961 qycapgdacr pgnftyhipv ssgtplhlsl tlqmnssspv svvlcslrsk eepceegslp
     1021 qslhthqdtq gtshrwpiti lsfreftyhf rvallgqanc ssealaqpat dyhfhfyrlc
     1081 d
//
LOCUS       XP_054225816            1074 aa            linear   PRI 05-AUG-2025
DEFINITION  myelin regulatory factor isoform X13 [Homo sapiens].
ACCESSION   XP_054225816
VERSION     XP_054225816.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369841.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1074
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1074
                     /product="myelin regulatory factor isoform X13"
                     /calculated_mol_wt=116136
     Region          342..489
                     /region_name="NDT80_PhoG"
                     /note="NDT80 / PhoG like DNA-binding family; pfam05224"
                     /db_xref="CDD:398753"
     Region          536..654
                     /region_name="Peptidase_S74_CIMCD"
                     /note="Peptidase S74 family, C-terminal intramolecular
                     chaperone domain of Escherichia coli phage K1F
                     endosialidase and related proteins; cd10144"
                     /db_xref="CDD:381748"
     Site            order(541..548,552,556..557,559,561..566,571,574,578..579,
                     581..588,602..606,610..611,613,615,634..637,639..642,
                     644..648,650..651)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:381748"
     Region          939..1073
                     /region_name="MRF_C2"
                     /note="Myelin gene regulatory factor C-terminal domain 2;
                     pfam13888"
                     /db_xref="CDD:464020"
     CDS             1..1074
                     /gene="MYRF"
                     /gene_synonym="11orf9; C11orf9; CUGS; MMERV; MRF; Ndt80;
                     NNO1; pqn-47"
                     /coded_by="XM_054369841.1:110..3334"
                     /db_xref="GeneID:745"
                     /db_xref="HGNC:HGNC:1181"
                     /db_xref="MIM:608329"
ORIGIN      
        1 mevvdeteal qrffeghdin galepsnidt sileeyiske dasdlcfpdi sapassasys
       61 hgqpampgss gvhhlsppgg gpspgrhgpl pppgygtpln cnnnngmgaa pkpfpggtgp
      121 pikaepkapy apgtlpdspp dsgseayspq qrdlymkaep piphyaamgq glvptdlhht
      181 qqsqmlhqll qqhgaelpth pskkrkhses ppstlnaqml ngmikqepgt vtalplhptr
      241 apsppwppqg plspgpgslp lsiarvqtpp whppgapspg llqdsdslsg syldpnyqsi
      301 kwqphqqnkw atlydanyke lpmltyrvda dkgfnfsvgd dafvcqkknh fqvtvyigml
      361 gepkyvktpe glkpldcfyl klhgvkleal nqsinieqsq sdrskrpfnp vtvnlppeqv
      421 tkvtvgrlhf settannmrk kgkpnpdqry fmlvvalqah aqnqnytlaa qiseriivra
      481 snpgqfesds dvlwqraqvp dtvfhhgrvg intdrpdeal vvhgnvkvmg slmhpsdlra
      541 kehvqevdtt eqlkrisrmr lvhyrykpef aasagieata petgviaqev keilpeavkd
      601 tgdmvfangk tienflvvnk erifmenvga vkelckltdn letrideler wshklaklrr
      661 ldslkstgss gafshagsqf sragsvphkk rppkvaskss svvpdqacis qrflqgtiia
      721 lvvvmafsvv smstlyvlsl rteedlvdtd grssqsfgtt qlrqsplttg lpgiqpslll
      781 vttsltssap gsavrtldmc sshpcpvicc sspttnpttg pslgpsfnpg hvlspspsps
      841 tnrsgpsqma llpvtnirak swglsvngig hskhhkslep laspavpfpg gqgkaknsps
      901 lgfhgrarrg alqssvgpae ptwaqgqsas llaepvpslt siqvlensms itsqycapgd
      961 acrpgnftyh ipvssgtplh lsltlqmnss spvsvvlcsl rskeepceeg slpqslhthq
     1021 dtqgtshrwp itilsfreft yhfrvallgq ancssealaq patdyhfhfy rlcd
//
LOCUS       XP_054225817            1073 aa            linear   PRI 05-AUG-2025
DEFINITION  myelin regulatory factor isoform X14 [Homo sapiens].
ACCESSION   XP_054225817
VERSION     XP_054225817.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369842.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1073
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1073
                     /product="myelin regulatory factor isoform X14"
                     /calculated_mol_wt=115980
     Region          342..489
                     /region_name="NDT80_PhoG"
                     /note="NDT80 / PhoG like DNA-binding family; pfam05224"
                     /db_xref="CDD:398753"
     Region          536..654
                     /region_name="Peptidase_S74_CIMCD"
                     /note="Peptidase S74 family, C-terminal intramolecular
                     chaperone domain of Escherichia coli phage K1F
                     endosialidase and related proteins; cd10144"
                     /db_xref="CDD:381748"
     Site            order(541..548,552,556..557,559,561..566,571,574,578..579,
                     581..588,602..606,610..611,613,615,634..637,639..642,
                     644..648,650..651)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:381748"
     Region          938..1072
                     /region_name="MRF_C2"
                     /note="Myelin gene regulatory factor C-terminal domain 2;
                     pfam13888"
                     /db_xref="CDD:464020"
     CDS             1..1073
                     /gene="MYRF"
                     /gene_synonym="11orf9; C11orf9; CUGS; MMERV; MRF; Ndt80;
                     NNO1; pqn-47"
                     /coded_by="XM_054369842.1:110..3331"
                     /db_xref="GeneID:745"
                     /db_xref="HGNC:HGNC:1181"
                     /db_xref="MIM:608329"
ORIGIN      
        1 mevvdeteal qrffeghdin galepsnidt sileeyiske dasdlcfpdi sapassasys
       61 hgqpampgss gvhhlsppgg gpspgrhgpl pppgygtpln cnnnngmgaa pkpfpggtgp
      121 pikaepkapy apgtlpdspp dsgseayspq qrdlymkaep piphyaamgq glvptdlhht
      181 qqsqmlhqll qqhgaelpth pskkrkhses ppstlnaqml ngmikqepgt vtalplhptr
      241 apsppwppqg plspgpgslp lsiarvqtpp whppgapspg llqdsdslsg syldpnyqsi
      301 kwqphqqnkw atlydanyke lpmltyrvda dkgfnfsvgd dafvcqkknh fqvtvyigml
      361 gepkyvktpe glkpldcfyl klhgvkleal nqsinieqsq sdrskrpfnp vtvnlppeqv
      421 tkvtvgrlhf settannmrk kgkpnpdqry fmlvvalqah aqnqnytlaa qiseriivra
      481 snpgqfesds dvlwqraqvp dtvfhhgrvg intdrpdeal vvhgnvkvmg slmhpsdlra
      541 kehvqevdtt eqlkrisrmr lvhyrykpef aasagieata petgviaqev keilpeavkd
      601 tgdmvfangk tienflvvnk erifmenvga vkelckltdn letrideler wshklaklrr
      661 ldslkstgss gafshagsqf sragsvphkk rppkvaskss svvpdqacis qrflqgtiia
      721 lvvvmafsvv smstlyvlsl rteedlvdtd gssqsfgttq lrqsplttgl pgiqpslllv
      781 ttsltssapg savrtldmcs shpcpviccs spttnpttgp slgpsfnpgh vlspspspst
      841 nrsgpsqmal lpvtniraks wglsvngigh skhhkslepl aspavpfpgg qgkaknspsl
      901 gfhgrarrga lqssvgpaep twaqgqsasl laepvpslts iqvlensmsi tsqycapgda
      961 crpgnftyhi pvssgtplhl sltlqmnsss pvsvvlcslr skeepceegs lpqslhthqd
     1021 tqgtshrwpi tilsfrefty hfrvallgqa ncssealaqp atdyhfhfyr lcd
//
LOCUS       XP_054225818            1069 aa            linear   PRI 05-AUG-2025
DEFINITION  myelin regulatory factor isoform X15 [Homo sapiens].
ACCESSION   XP_054225818
VERSION     XP_054225818.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369843.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1069
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1069
                     /product="myelin regulatory factor isoform X15"
                     /calculated_mol_wt=115680
     Region          342..489
                     /region_name="NDT80_PhoG"
                     /note="NDT80 / PhoG like DNA-binding family; pfam05224"
                     /db_xref="CDD:398753"
     Region          536..654
                     /region_name="Peptidase_S74_CIMCD"
                     /note="Peptidase S74 family, C-terminal intramolecular
                     chaperone domain of Escherichia coli phage K1F
                     endosialidase and related proteins; cd10144"
                     /db_xref="CDD:381748"
     Site            order(541..548,552,556..557,559,561..566,571,574,578..579,
                     581..588,602..606,610..611,613,615,634..637,639..642,
                     644..648,650..651)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:381748"
     Region          934..1068
                     /region_name="MRF_C2"
                     /note="Myelin gene regulatory factor C-terminal domain 2;
                     pfam13888"
                     /db_xref="CDD:464020"
     CDS             1..1069
                     /gene="MYRF"
                     /gene_synonym="11orf9; C11orf9; CUGS; MMERV; MRF; Ndt80;
                     NNO1; pqn-47"
                     /coded_by="XM_054369843.1:110..3319"
                     /db_xref="GeneID:745"
                     /db_xref="HGNC:HGNC:1181"
                     /db_xref="MIM:608329"
ORIGIN      
        1 mevvdeteal qrffeghdin galepsnidt sileeyiske dasdlcfpdi sapassasys
       61 hgqpampgss gvhhlsppgg gpspgrhgpl pppgygtpln cnnnngmgaa pkpfpggtgp
      121 pikaepkapy apgtlpdspp dsgseayspq qrdlymkaep piphyaamgq glvptdlhht
      181 qqsqmlhqll qqhgaelpth pskkrkhses ppstlnaqml ngmikqepgt vtalplhptr
      241 apsppwppqg plspgpgslp lsiarvqtpp whppgapspg llqdsdslsg syldpnyqsi
      301 kwqphqqnkw atlydanyke lpmltyrvda dkgfnfsvgd dafvcqkknh fqvtvyigml
      361 gepkyvktpe glkpldcfyl klhgvkleal nqsinieqsq sdrskrpfnp vtvnlppeqv
      421 tkvtvgrlhf settannmrk kgkpnpdqry fmlvvalqah aqnqnytlaa qiseriivra
      481 snpgqfesds dvlwqraqvp dtvfhhgrvg intdrpdeal vvhgnvkvmg slmhpsdlra
      541 kehvqevdtt eqlkrisrmr lvhyrykpef aasagieata petgviaqev keilpeavkd
      601 tgdmvfangk tienflvvnk erifmenvga vkelckltdn letrideler wshklaklrr
      661 ldslkstgss gafshagsqf sragsvphkk rppkvaskss svvpdqacis qrflqgtiia
      721 lvvvmafsvv smstlyvlsl rteedlvdtd grssqsfgtt qlrqsplttg lpgiqpslll
      781 vttsltssap gsavrtldmc sshpcpvicc sspttnpttg pslgpsfnpg hvlspspsps
      841 tnrsgpsqma llpvtnirak swglsvngig hskhhkslep laspavpfpg gqgkaknsps
      901 lgfhgrarrg alqssvgpae ptwaqgqsep vpsltsiqvl ensmsitsqy capgdacrpg
      961 nftyhipvss gtplhlsltl qmnssspvsv vlcslrskee pceegslpqs lhthqdtqgt
     1021 shrwpitils freftyhfrv allgqancss ealaqpatdy hfhfyrlcd
//
LOCUS       XP_054225819            1068 aa            linear   PRI 05-AUG-2025
DEFINITION  myelin regulatory factor isoform X16 [Homo sapiens].
ACCESSION   XP_054225819
VERSION     XP_054225819.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369844.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1068
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1068
                     /product="myelin regulatory factor isoform X16"
                     /calculated_mol_wt=115524
     Region          342..489
                     /region_name="NDT80_PhoG"
                     /note="NDT80 / PhoG like DNA-binding family; pfam05224"
                     /db_xref="CDD:398753"
     Region          536..654
                     /region_name="Peptidase_S74_CIMCD"
                     /note="Peptidase S74 family, C-terminal intramolecular
                     chaperone domain of Escherichia coli phage K1F
                     endosialidase and related proteins; cd10144"
                     /db_xref="CDD:381748"
     Site            order(541..548,552,556..557,559,561..566,571,574,578..579,
                     581..588,602..606,610..611,613,615,634..637,639..642,
                     644..648,650..651)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:381748"
     Region          933..1067
                     /region_name="MRF_C2"
                     /note="Myelin gene regulatory factor C-terminal domain 2;
                     pfam13888"
                     /db_xref="CDD:464020"
     CDS             1..1068
                     /gene="MYRF"
                     /gene_synonym="11orf9; C11orf9; CUGS; MMERV; MRF; Ndt80;
                     NNO1; pqn-47"
                     /coded_by="XM_054369844.1:110..3316"
                     /db_xref="GeneID:745"
                     /db_xref="HGNC:HGNC:1181"
                     /db_xref="MIM:608329"
ORIGIN      
        1 mevvdeteal qrffeghdin galepsnidt sileeyiske dasdlcfpdi sapassasys
       61 hgqpampgss gvhhlsppgg gpspgrhgpl pppgygtpln cnnnngmgaa pkpfpggtgp
      121 pikaepkapy apgtlpdspp dsgseayspq qrdlymkaep piphyaamgq glvptdlhht
      181 qqsqmlhqll qqhgaelpth pskkrkhses ppstlnaqml ngmikqepgt vtalplhptr
      241 apsppwppqg plspgpgslp lsiarvqtpp whppgapspg llqdsdslsg syldpnyqsi
      301 kwqphqqnkw atlydanyke lpmltyrvda dkgfnfsvgd dafvcqkknh fqvtvyigml
      361 gepkyvktpe glkpldcfyl klhgvkleal nqsinieqsq sdrskrpfnp vtvnlppeqv
      421 tkvtvgrlhf settannmrk kgkpnpdqry fmlvvalqah aqnqnytlaa qiseriivra
      481 snpgqfesds dvlwqraqvp dtvfhhgrvg intdrpdeal vvhgnvkvmg slmhpsdlra
      541 kehvqevdtt eqlkrisrmr lvhyrykpef aasagieata petgviaqev keilpeavkd
      601 tgdmvfangk tienflvvnk erifmenvga vkelckltdn letrideler wshklaklrr
      661 ldslkstgss gafshagsqf sragsvphkk rppkvaskss svvpdqacis qrflqgtiia
      721 lvvvmafsvv smstlyvlsl rteedlvdtd gssqsfgttq lrqsplttgl pgiqpslllv
      781 ttsltssapg savrtldmcs shpcpviccs spttnpttgp slgpsfnpgh vlspspspst
      841 nrsgpsqmal lpvtniraks wglsvngigh skhhkslepl aspavpfpgg qgkaknspsl
      901 gfhgrarrga lqssvgpaep twaqgqsepv psltsiqvle nsmsitsqyc apgdacrpgn
      961 ftyhipvssg tplhlsltlq mnssspvsvv lcslrskeep ceegslpqsl hthqdtqgts
     1021 hrwpitilsf reftyhfrva llgqancsse alaqpatdyh fhfyrlcd
//
LOCUS       XP_054225820            1055 aa            linear   PRI 05-AUG-2025
DEFINITION  myelin regulatory factor isoform X17 [Homo sapiens].
ACCESSION   XP_054225820
VERSION     XP_054225820.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369845.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1055
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1055
                     /product="myelin regulatory factor isoform X17"
                     /calculated_mol_wt=114155
     Region          328..475
                     /region_name="NDT80_PhoG"
                     /note="NDT80 / PhoG like DNA-binding family; pfam05224"
                     /db_xref="CDD:398753"
     Region          522..640
                     /region_name="Peptidase_S74_CIMCD"
                     /note="Peptidase S74 family, C-terminal intramolecular
                     chaperone domain of Escherichia coli phage K1F
                     endosialidase and related proteins; cd10144"
                     /db_xref="CDD:381748"
     Site            order(527..534,538,542..543,545,547..552,557,560,564..565,
                     567..574,588..592,596..597,599,601,620..623,625..628,
                     630..634,636..637)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:381748"
     Region          920..1054
                     /region_name="MRF_C2"
                     /note="Myelin gene regulatory factor C-terminal domain 2;
                     pfam13888"
                     /db_xref="CDD:464020"
     CDS             1..1055
                     /gene="MYRF"
                     /gene_synonym="11orf9; C11orf9; CUGS; MMERV; MRF; Ndt80;
                     NNO1; pqn-47"
                     /coded_by="XM_054369845.1:638..3805"
                     /db_xref="GeneID:745"
                     /db_xref="HGNC:HGNC:1181"
                     /db_xref="MIM:608329"
ORIGIN      
        1 mpgssgvhhl sppgggpspg rhgplpppgy gtplncnnnn gmgaapkpfp ggtgppikae
       61 pkapyapgtl pdsppdsgse ayspqqvnep hllrtitpet lchvgvpsrl ehpppppahl
      121 pgpppppppp phypvlqrdl ymkaeppiph yaamgqglvp tdlhhtqqsq mlhqllqqhg
      181 aelpthpskk rkhsesppst lnaqmlngmi kqepgtvtal plhptrapsp pwppqgplsp
      241 gpgslplsia rvqtppwhpp gapspgllqd sdslsgsyld pnyqsikwqp hqqnkwatly
      301 danykelpml tyrvdadkgf nfsvgddafv cqkknhfqvt vyigmlgepk yvktpeglkp
      361 ldcfylklhg vklealnqsi nieqsqsdrs krpfnpvtvn lppeqvtkvt vgrlhfsett
      421 annmrkkgkp npdqryfmlv valqahaqnq nytlaaqise riivrasnpg qfesdsdvlw
      481 qraqvpdtvf hhgrvgintd rpdealvvhg nvkvmgslmh psdlrakehv qevdtteqlk
      541 risrmrlvhy rykpefaasa gieatapetg viaqevkeil peavkdtgdm vfangktien
      601 flvvnkerif menvgavkel ckltdnletr idelerwshk laklrrldsl kstgssgafs
      661 hagsqfsrag svphkkrppk vasksssvvp dqacisqrfl qgtiialvvv mafsvvsmst
      721 lyvlslrtee dlvdtdgrss qsfgttqlrq splttglpgi qpslllvtts ltssapgsav
      781 rtldmcsshp cpviccsspt tnpttgpslg psfnpghvls pspspstnrs gpsqmallpv
      841 tnirakswgl svngighskh hksleplasp avpfpggqgk aknspslgfh grarrgalqs
      901 svgpaeptwa qgqsepvpsl tsiqvlensm sitsqycapg dacrpgnfty hipvssgtpl
      961 hlsltlqmns sspvsvvlcs lrskeepcee gslpqslhth qdtqgtshrw pitilsfref
     1021 tyhfrvallg qancsseala qpatdyhfhf yrlcd
//
LOCUS       XP_054225821            1005 aa            linear   PRI 05-AUG-2025
DEFINITION  myelin regulatory factor isoform X18 [Homo sapiens].
ACCESSION   XP_054225821
VERSION     XP_054225821.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369846.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1005
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1005
                     /product="myelin regulatory factor isoform X18"
                     /calculated_mol_wt=109306
     Region          246..393
                     /region_name="NDT80_PhoG"
                     /note="NDT80 / PhoG like DNA-binding family; pfam05224"
                     /db_xref="CDD:398753"
     Region          440..558
                     /region_name="Peptidase_S74_CIMCD"
                     /note="Peptidase S74 family, C-terminal intramolecular
                     chaperone domain of Escherichia coli phage K1F
                     endosialidase and related proteins; cd10144"
                     /db_xref="CDD:381748"
     Site            order(445..452,456,460..461,463,465..470,475,478,482..483,
                     485..492,506..510,514..515,517,519,538..541,543..546,
                     548..552,554..555)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:381748"
     Region          870..1004
                     /region_name="MRF_C2"
                     /note="Myelin gene regulatory factor C-terminal domain 2;
                     pfam13888"
                     /db_xref="CDD:464020"
     CDS             1..1005
                     /gene="MYRF"
                     /gene_synonym="11orf9; C11orf9; CUGS; MMERV; MRF; Ndt80;
                     NNO1; pqn-47"
                     /coded_by="XM_054369846.1:148..3165"
                     /db_xref="GeneID:745"
                     /db_xref="HGNC:HGNC:1181"
                     /db_xref="MIM:608329"
ORIGIN      
        1 mdapfgephl lrtitpetlc hvgvpsrleh pppppahlpg ppppppppph ypvlqrdlym
       61 kaeppiphya amgqglvptd lhhtqqsqml hqllqqhgae lpthpskkrk hsesppstln
      121 aqmlngmikq epgtvtalpl hptrapsppw ppqgplspgp gslplsiarv qtppwhppga
      181 pspgllqdsd slsgsyldpn yqsikwqphq qnkwatlyda nykelpmlty rvdadkgfnf
      241 svgddafvcq kknhfqvtvy igmlgepkyv ktpeglkpld cfylklhgvk lealnqsini
      301 eqsqsdrskr pfnpvtvnlp peqvtkvtvg rlhfsettan nmrkkgkpnp dqryfmlvva
      361 lqahaqnqny tlaaqiseri ivrasnpgqf esdsdvlwqr aqvpdtvfhh grvgintdrp
      421 dealvvhgnv kvmgslmhps dlrakehvqe vdtteqlkri srmrlvhyry kpefaasagi
      481 eatapetgvi aqevkeilpe avkdtgdmvf angktienfl vvnkerifme nvgavkelck
      541 ltdnletrid elerwshkla klrrldslks tgssgafsha gsqfsragsv phkkrppkva
      601 sksssvvpdq acisqrflqg tiialvvvma fsvvsmstly vlslrteedl vdtdgsfavs
      661 tscllallrp qppggsealc pcrssqsfgt tqlrqspltt glpgiqpsll lvttsltssa
      721 pgsavrtldm csshpcpvic csspttnptt gpslgpsfnp ghvlspspsp stnrsgpsqm
      781 allpvtnira kswglsvngi ghskhhksle plaspavpfp ggqgkaknsp slgfhgrarr
      841 galqssvgpa eptwaqgqsa sllaepvpsl tsiqvlensm sitsqycapg dacrpgnfty
      901 hipvssgtpl hlsltlqmns sspvsvvlcs lrskeepcee gslpqslhth qdtqgtshrw
      961 pitilsfref tyhfrvallg qancsseala qpatdyhfhf yrlcd
//
LOCUS       XP_054225822            1004 aa            linear   PRI 05-AUG-2025
DEFINITION  myelin regulatory factor isoform X19 [Homo sapiens].
ACCESSION   XP_054225822
VERSION     XP_054225822.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369847.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1004
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1004
                     /product="myelin regulatory factor isoform X19"
                     /calculated_mol_wt=109233
     Region          246..393
                     /region_name="NDT80_PhoG"
                     /note="NDT80 / PhoG like DNA-binding family; pfam05224"
                     /db_xref="CDD:398753"
     Region          440..558
                     /region_name="Peptidase_S74_CIMCD"
                     /note="Peptidase S74 family, C-terminal intramolecular
                     chaperone domain of Escherichia coli phage K1F
                     endosialidase and related proteins; cd10144"
                     /db_xref="CDD:381748"
     Site            order(445..452,456,460..461,463,465..470,475,478,482..483,
                     485..492,506..510,514..515,517,519,538..541,543..546,
                     548..552,554..555)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:381748"
     Region          869..1003
                     /region_name="MRF_C2"
                     /note="Myelin gene regulatory factor C-terminal domain 2;
                     pfam13888"
                     /db_xref="CDD:464020"
     CDS             1..1004
                     /gene="MYRF"
                     /gene_synonym="11orf9; C11orf9; CUGS; MMERV; MRF; Ndt80;
                     NNO1; pqn-47"
                     /coded_by="XM_054369847.1:148..3162"
                     /db_xref="GeneID:745"
                     /db_xref="HGNC:HGNC:1181"
                     /db_xref="MIM:608329"
ORIGIN      
        1 mdapfgephl lrtitpetlc hvgvpsrleh pppppahlpg ppppppppph ypvlqrdlym
       61 kaeppiphya amgqglvptd lhhtqqsqml hqllqqhgae lpthpskkrk hsesppstln
      121 aqmlngmikq epgtvtalpl hptrapsppw ppqgplspgp gslplsiarv qtppwhppga
      181 pspgllqdsd slsgsyldpn yqsikwqphq qnkwatlyda nykelpmlty rvdadkgfnf
      241 svgddafvcq kknhfqvtvy igmlgepkyv ktpeglkpld cfylklhgvk lealnqsini
      301 eqsqsdrskr pfnpvtvnlp peqvtkvtvg rlhfsettan nmrkkgkpnp dqryfmlvva
      361 lqahaqnqny tlaaqiseri ivrasnpgqf esdsdvlwqr aqvpdtvfhh grvgintdrp
      421 dealvvhgnv kvmgslmhps dlrakehvqe vdtteqlkri srmrlvhyry kpefaasagi
      481 eatapetgvi aqevkeilpe avkdtgdmvf angktienfl vvnkerifme nvgavkelck
      541 ltdnletrid elerwshkla klrrldslks tgssgafsha gsqfsragsv phkkrppkva
      601 sksssvvpdq acisqrflqg tiialvvvma fsvvsmstly vlslrteedl vdtdgsfavs
      661 tscllallrp qppggsealc pwssqsfgtt qlrqsplttg lpgiqpslll vttsltssap
      721 gsavrtldmc sshpcpvicc sspttnpttg pslgpsfnpg hvlspspsps tnrsgpsqma
      781 llpvtnirak swglsvngig hskhhkslep laspavpfpg gqgkaknsps lgfhgrarrg
      841 alqssvgpae ptwaqgqsas llaepvpslt siqvlensms itsqycapgd acrpgnftyh
      901 ipvssgtplh lsltlqmnss spvsvvlcsl rskeepceeg slpqslhthq dtqgtshrwp
      961 itilsfreft yhfrvallgq ancssealaq patdyhfhfy rlcd
//
LOCUS       XP_054225823             973 aa            linear   PRI 05-AUG-2025
DEFINITION  myelin regulatory factor isoform X20 [Homo sapiens].
ACCESSION   XP_054225823
VERSION     XP_054225823.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369848.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..973
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..973
                     /product="myelin regulatory factor isoform X20"
                     /calculated_mol_wt=106150
     Region          246..393
                     /region_name="NDT80_PhoG"
                     /note="NDT80 / PhoG like DNA-binding family; pfam05224"
                     /db_xref="CDD:398753"
     Region          440..558
                     /region_name="Peptidase_S74_CIMCD"
                     /note="Peptidase S74 family, C-terminal intramolecular
                     chaperone domain of Escherichia coli phage K1F
                     endosialidase and related proteins; cd10144"
                     /db_xref="CDD:381748"
     Site            order(445..452,456,460..461,463,465..470,475,478,482..483,
                     485..492,506..510,514..515,517,519,538..541,543..546,
                     548..552,554..555)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:381748"
     Region          838..972
                     /region_name="MRF_C2"
                     /note="Myelin gene regulatory factor C-terminal domain 2;
                     pfam13888"
                     /db_xref="CDD:464020"
     CDS             1..973
                     /gene="MYRF"
                     /gene_synonym="11orf9; C11orf9; CUGS; MMERV; MRF; Ndt80;
                     NNO1; pqn-47"
                     /coded_by="XM_054369848.1:144..3065"
                     /db_xref="GeneID:745"
                     /db_xref="HGNC:HGNC:1181"
                     /db_xref="MIM:608329"
ORIGIN      
        1 mdapfgephl lrtitpetlc hvgvpsrleh pppppahlpg ppppppppph ypvlqrdlym
       61 kaeppiphya amgqglvptd lhhtqqsqml hqllqqhgae lpthpskkrk hsesppstln
      121 aqmlngmikq epgtvtalpl hptrapsppw ppqgplspgp gslplsiarv qtppwhppga
      181 pspgllqdsd slsgsyldpn yqsikwqphq qnkwatlyda nykelpmlty rvdadkgfnf
      241 svgddafvcq kknhfqvtvy igmlgepkyv ktpeglkpld cfylklhgvk lealnqsini
      301 eqsqsdrskr pfnpvtvnlp peqvtkvtvg rlhfsettan nmrkkgkpnp dqryfmlvva
      361 lqahaqnqny tlaaqiseri ivrasnpgqf esdsdvlwqr aqvpdtvfhh grvgintdrp
      421 dealvvhgnv kvmgslmhps dlrakehvqe vdtteqlkri srmrlvhyry kpefaasagi
      481 eatapetgvi aqevkeilpe avkdtgdmvf angktienfl vvnkerifme nvgavkelck
      541 ltdnletrid elerwshkla klrrldslks tgssgafsha gsqfsragsv phkkrppkva
      601 sksssvvpdq acisqrflqg tiialvvvma fsvvsmstly vlslrteedl vdtdgrssqs
      661 fgttqlrqsp lttglpgiqp slllvttslt ssapgsavrt ldmcsshpcp viccsspttn
      721 pttgpslgps fnpghvlsps pspstnrsgp sqmallpvtn irakswglsv ngighskhhk
      781 sleplaspav pfpggqgkak nspslgfhgr arrgalqssv gpaeptwaqg qsepvpslts
      841 iqvlensmsi tsqycapgda crpgnftyhi pvssgtplhl sltlqmnsss pvsvvlcslr
      901 skeepceegs lpqslhthqd tqgtshrwpi tilsfrefty hfrvallgqa ncssealaqp
      961 atdyhfhfyr lcd
//
LOCUS       XP_054225824             972 aa            linear   PRI 05-AUG-2025
DEFINITION  myelin regulatory factor isoform X21 [Homo sapiens].
ACCESSION   XP_054225824
VERSION     XP_054225824.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369849.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..972
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..972
                     /product="myelin regulatory factor isoform X21"
                     /calculated_mol_wt=105994
     Region          246..393
                     /region_name="NDT80_PhoG"
                     /note="NDT80 / PhoG like DNA-binding family; pfam05224"
                     /db_xref="CDD:398753"
     Region          440..558
                     /region_name="Peptidase_S74_CIMCD"
                     /note="Peptidase S74 family, C-terminal intramolecular
                     chaperone domain of Escherichia coli phage K1F
                     endosialidase and related proteins; cd10144"
                     /db_xref="CDD:381748"
     Site            order(445..452,456,460..461,463,465..470,475,478,482..483,
                     485..492,506..510,514..515,517,519,538..541,543..546,
                     548..552,554..555)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:381748"
     Region          837..971
                     /region_name="MRF_C2"
                     /note="Myelin gene regulatory factor C-terminal domain 2;
                     pfam13888"
                     /db_xref="CDD:464020"
     CDS             1..972
                     /gene="MYRF"
                     /gene_synonym="11orf9; C11orf9; CUGS; MMERV; MRF; Ndt80;
                     NNO1; pqn-47"
                     /coded_by="XM_054369849.1:144..3062"
                     /db_xref="GeneID:745"
                     /db_xref="HGNC:HGNC:1181"
                     /db_xref="MIM:608329"
ORIGIN      
        1 mdapfgephl lrtitpetlc hvgvpsrleh pppppahlpg ppppppppph ypvlqrdlym
       61 kaeppiphya amgqglvptd lhhtqqsqml hqllqqhgae lpthpskkrk hsesppstln
      121 aqmlngmikq epgtvtalpl hptrapsppw ppqgplspgp gslplsiarv qtppwhppga
      181 pspgllqdsd slsgsyldpn yqsikwqphq qnkwatlyda nykelpmlty rvdadkgfnf
      241 svgddafvcq kknhfqvtvy igmlgepkyv ktpeglkpld cfylklhgvk lealnqsini
      301 eqsqsdrskr pfnpvtvnlp peqvtkvtvg rlhfsettan nmrkkgkpnp dqryfmlvva
      361 lqahaqnqny tlaaqiseri ivrasnpgqf esdsdvlwqr aqvpdtvfhh grvgintdrp
      421 dealvvhgnv kvmgslmhps dlrakehvqe vdtteqlkri srmrlvhyry kpefaasagi
      481 eatapetgvi aqevkeilpe avkdtgdmvf angktienfl vvnkerifme nvgavkelck
      541 ltdnletrid elerwshkla klrrldslks tgssgafsha gsqfsragsv phkkrppkva
      601 sksssvvpdq acisqrflqg tiialvvvma fsvvsmstly vlslrteedl vdtdgssqsf
      661 gttqlrqspl ttglpgiqps lllvttslts sapgsavrtl dmcsshpcpv iccsspttnp
      721 ttgpslgpsf npghvlspsp spstnrsgps qmallpvtni rakswglsvn gighskhhks
      781 leplaspavp fpggqgkakn spslgfhgra rrgalqssvg paeptwaqgq sepvpsltsi
      841 qvlensmsit sqycapgdac rpgnftyhip vssgtplhls ltlqmnsssp vsvvlcslrs
      901 keepceegsl pqslhthqdt qgtshrwpit ilsfreftyh frvallgqan cssealaqpa
      961 tdyhfhfyrl cd
//
LOCUS       XP_054225825             951 aa            linear   PRI 05-AUG-2025
DEFINITION  myelin regulatory factor isoform X22 [Homo sapiens].
ACCESSION   XP_054225825
VERSION     XP_054225825.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369850.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..951
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..951
                     /product="myelin regulatory factor isoform X22"
                     /calculated_mol_wt=103528
     Region          192..339
                     /region_name="NDT80_PhoG"
                     /note="NDT80 / PhoG like DNA-binding family; pfam05224"
                     /db_xref="CDD:398753"
     Region          386..504
                     /region_name="Peptidase_S74_CIMCD"
                     /note="Peptidase S74 family, C-terminal intramolecular
                     chaperone domain of Escherichia coli phage K1F
                     endosialidase and related proteins; cd10144"
                     /db_xref="CDD:381748"
     Site            order(391..398,402,406..407,409,411..416,421,424,428..429,
                     431..438,452..456,460..461,463,465,484..487,489..492,
                     494..498,500..501)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:381748"
     Region          816..950
                     /region_name="MRF_C2"
                     /note="Myelin gene regulatory factor C-terminal domain 2;
                     pfam13888"
                     /db_xref="CDD:464020"
     CDS             1..951
                     /gene="MYRF"
                     /gene_synonym="11orf9; C11orf9; CUGS; MMERV; MRF; Ndt80;
                     NNO1; pqn-47"
                     /coded_by="XM_054369850.1:16..2871"
                     /db_xref="GeneID:745"
                     /db_xref="HGNC:HGNC:1181"
                     /db_xref="MIM:608329"
ORIGIN      
        1 mrdlymkaep piphyaamgq glvptdlhht qqsqmlhqll qqhgaelpth pskkrkhses
       61 ppstlnaqml ngmikqepgt vtalplhptr apsppwppqg plspgpgslp lsiarvqtpp
      121 whppgapspg llqdsdslsg syldpnyqsi kwqphqqnkw atlydanyke lpmltyrvda
      181 dkgfnfsvgd dafvcqkknh fqvtvyigml gepkyvktpe glkpldcfyl klhgvkleal
      241 nqsinieqsq sdrskrpfnp vtvnlppeqv tkvtvgrlhf settannmrk kgkpnpdqry
      301 fmlvvalqah aqnqnytlaa qiseriivra snpgqfesds dvlwqraqvp dtvfhhgrvg
      361 intdrpdeal vvhgnvkvmg slmhpsdlra kehvqevdtt eqlkrisrmr lvhyrykpef
      421 aasagieata petgviaqev keilpeavkd tgdmvfangk tienflvvnk erifmenvga
      481 vkelckltdn letrideler wshklaklrr ldslkstgss gafshagsqf sragsvphkk
      541 rppkvaskss svvpdqacis qrflqgtiia lvvvmafsvv smstlyvlsl rteedlvdtd
      601 gsfavstscl lallrpqppg gsealcpcrs sqsfgttqlr qsplttglpg iqpslllvtt
      661 sltssapgsa vrtldmcssh pcpviccssp ttnpttgpsl gpsfnpghvl spspspstnr
      721 sgpsqmallp vtnirakswg lsvngighsk hhksleplas pavpfpggqg kaknspslgf
      781 hgrarrgalq ssvgpaeptw aqgqsaslla epvpsltsiq vlensmsits qycapgdacr
      841 pgnftyhipv ssgtplhlsl tlqmnssspv svvlcslrsk eepceegslp qslhthqdtq
      901 gtshrwpiti lsfreftyhf rvallgqanc ssealaqpat dyhfhfyrlc d
//
LOCUS       XP_054225826             432 aa            linear   PRI 05-AUG-2025
DEFINITION  wee1-like protein kinase isoform X1 [Homo sapiens].
ACCESSION   XP_054225826
VERSION     XP_054225826.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369851.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..432
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..432
                     /product="wee1-like protein kinase isoform X1"
                     /calculated_mol_wt=48941
     Region          79..354
                     /region_name="PTKc_Wee1a"
                     /note="Catalytic domain of the Protein Tyrosine Kinase,
                     Wee1a; cd14138"
                     /db_xref="CDD:271040"
     Site            order(91..95,99,112,114,146,162..165,169,171,212,214,
                     216..217,219,249,252,264..267)
                     /site_type="active"
                     /db_xref="CDD:271040"
     Site            order(91..95,99,112,114,146,162..165,169,212,214,216..217,
                     219,249)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271040"
     Site            order(95,169,171,212,214,216,252,264..267)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:271040"
     Site            248..267
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:271040"
     CDS             1..432
                     /gene="WEE1"
                     /gene_synonym="WEE1A; WEE1hu"
                     /coded_by="XM_054369851.1:84..1382"
                     /db_xref="GeneID:7465"
                     /db_xref="HGNC:HGNC:12761"
                     /db_xref="MIM:193525"
ORIGIN      
        1 mdteksgkre fdvrqtpqvn inpftpdsll lhssgqcrrr krtywndscg edmeasdyel
       61 edetrpakri titesnmksr yttefhelek igsgefgsvf kcvkrldgci yaikrskkpl
      121 agsvdeqnal revyahavlg qhshvvryfs awaeddhmli qneycnggsl adaisenyri
      181 msyfkeaelk dlllqvgrgl ryihsmslvh mdikpsnifi srtsipnaas eegdeddwas
      241 nkvmfkigdl ghvtrisspq veegdsrfla nevlqenyth lpkadifala ltvvcaagae
      301 plprngdqwh eirqgrlpri pqvlsqefte llkvmihpdp errpsamalv khsvllsasr
      361 ksaeqlriel naekfknsll qkelkkaqma kaaaeeralf tdrmatrstt qsnrtsrlig
      421 kkmnrsvslt iy
//
LOCUS       XP_054225827            1042 aa            linear   PRI 05-AUG-2025
DEFINITION  diacylglycerol lipase-alpha isoform X1 [Homo sapiens].
ACCESSION   XP_054225827
VERSION     XP_054225827.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369852.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1042
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1042
                     /product="diacylglycerol lipase-alpha isoform X1"
                     /calculated_mol_wt=114821
     Region          288..529
                     /region_name="Lipase_3"
                     /note="Lipase (class 3). Lipases are esterases that can
                     hydrolyze long-chain acyl-triglycerides into di- and
                     monoglycerides, glycerol, and free fatty acids at a
                     water/lipid interface. A typical feature of lipases is
                     'interfacial activation,' the process of...; cd00519"
                     /db_xref="CDD:238287"
     Site            order(400..401,403..411)
                     /site_type="active"
                     /note="active site flap/lid [active]"
                     /db_xref="CDD:238287"
     Site            470..474
                     /site_type="active"
                     /note="nucleophilic elbow [active]"
                     /db_xref="CDD:238287"
     CDS             1..1042
                     /gene="DAGLA"
                     /gene_synonym="C11orf11; DAGL(ALPHA); DAGLALPHA; NOC2;
                     NSDDR"
                     /coded_by="XM_054369852.1:269..3397"
                     /db_xref="GeneID:747"
                     /db_xref="HGNC:HGNC:1165"
                     /db_xref="MIM:614015"
ORIGIN      
        1 mpgivvfrrr wsvgsddlvl paiflfllht twfvilsvvl fglvynphea cslnlvdhgr
       61 gylgillscm iaemaiiwls mrggilytep rdsmqyvlyv rlailviefi yaivgivwlt
      121 qyytscndlt aknvtlgmvv cnwvvilsvc itvlcvfdpt grtfvklrat krrqrnlrty
      181 nlrhrleegq atswsrrlkv flcctrtkds qsdayseiay lfaeffrdld ivpsdiiagl
      241 vllrqrqrak rnavldeann dilaflsgmp vtrntkyldl knsqemlryk evcyymlfal
      301 aaygwpmylm rkpacglcql arscscclcp arprfapgvt ieednccgcn aiairrhfld
      361 enmtavdivy tschdavyet pfyvavdhdk kkvvisirgt lspkdaltdl tgdaerlpve
      421 ghhgtwlghk gmvlsaeyik kkleqemvls qafgrdlgrg tkhyglivvg hslgagtaai
      481 lsfllrpqyp tlkcfayspp ggllsedame yskefvtavv lgkdlvprig lsqlegfrrq
      541 lldvlqrstk pkwriivgat kcipkselpe evevttlast rlwthpsdlt ialsastply
      601 ppgriihvvh nhpaeqcccc eqeeptyfai wgdnkafnev iispamlheh lpyvvmegln
      661 kvlenynkgk tallsaakvm vsptevdltp elifqqqplp tgppmptgla lelptadhrn
      721 ssvrsksqse mslegfsegr llspvvaaaa rqdpvellll stqerlaael qarraplatm
      781 eslsdtesly sfdsrrssgf rsirgspslh avlerdeghl fyidpaipee npslssrtel
      841 laadslskhs qdtqpleaal gsggvtperp psaaandeee evggggggpa srgelalhng
      901 rlgdspspqv lefaefidsl fnldsksssf qdlycmvvpe sptsdyaegp kspsqqeill
      961 raqfepnlvp kpprlfagsa dpssgislsp sfplsssgel mdltptglss qeclaadkir
     1021 tstptghgas pakqdelvis ar
//
LOCUS       XP_054225828            1042 aa            linear   PRI 05-AUG-2025
DEFINITION  diacylglycerol lipase-alpha isoform X1 [Homo sapiens].
ACCESSION   XP_054225828
VERSION     XP_054225828.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369853.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1042
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1042
                     /product="diacylglycerol lipase-alpha isoform X1"
                     /calculated_mol_wt=114821
     Region          288..529
                     /region_name="Lipase_3"
                     /note="Lipase (class 3). Lipases are esterases that can
                     hydrolyze long-chain acyl-triglycerides into di- and
                     monoglycerides, glycerol, and free fatty acids at a
                     water/lipid interface. A typical feature of lipases is
                     'interfacial activation,' the process of...; cd00519"
                     /db_xref="CDD:238287"
     Site            order(400..401,403..411)
                     /site_type="active"
                     /note="active site flap/lid [active]"
                     /db_xref="CDD:238287"
     Site            470..474
                     /site_type="active"
                     /note="nucleophilic elbow [active]"
                     /db_xref="CDD:238287"
     CDS             1..1042
                     /gene="DAGLA"
                     /gene_synonym="C11orf11; DAGL(ALPHA); DAGLALPHA; NOC2;
                     NSDDR"
                     /coded_by="XM_054369853.1:1783..4911"
                     /db_xref="GeneID:747"
                     /db_xref="HGNC:HGNC:1165"
                     /db_xref="MIM:614015"
ORIGIN      
        1 mpgivvfrrr wsvgsddlvl paiflfllht twfvilsvvl fglvynphea cslnlvdhgr
       61 gylgillscm iaemaiiwls mrggilytep rdsmqyvlyv rlailviefi yaivgivwlt
      121 qyytscndlt aknvtlgmvv cnwvvilsvc itvlcvfdpt grtfvklrat krrqrnlrty
      181 nlrhrleegq atswsrrlkv flcctrtkds qsdayseiay lfaeffrdld ivpsdiiagl
      241 vllrqrqrak rnavldeann dilaflsgmp vtrntkyldl knsqemlryk evcyymlfal
      301 aaygwpmylm rkpacglcql arscscclcp arprfapgvt ieednccgcn aiairrhfld
      361 enmtavdivy tschdavyet pfyvavdhdk kkvvisirgt lspkdaltdl tgdaerlpve
      421 ghhgtwlghk gmvlsaeyik kkleqemvls qafgrdlgrg tkhyglivvg hslgagtaai
      481 lsfllrpqyp tlkcfayspp ggllsedame yskefvtavv lgkdlvprig lsqlegfrrq
      541 lldvlqrstk pkwriivgat kcipkselpe evevttlast rlwthpsdlt ialsastply
      601 ppgriihvvh nhpaeqcccc eqeeptyfai wgdnkafnev iispamlheh lpyvvmegln
      661 kvlenynkgk tallsaakvm vsptevdltp elifqqqplp tgppmptgla lelptadhrn
      721 ssvrsksqse mslegfsegr llspvvaaaa rqdpvellll stqerlaael qarraplatm
      781 eslsdtesly sfdsrrssgf rsirgspslh avlerdeghl fyidpaipee npslssrtel
      841 laadslskhs qdtqpleaal gsggvtperp psaaandeee evggggggpa srgelalhng
      901 rlgdspspqv lefaefidsl fnldsksssf qdlycmvvpe sptsdyaegp kspsqqeill
      961 raqfepnlvp kpprlfagsa dpssgislsp sfplsssgel mdltptglss qeclaadkir
     1021 tstptghgas pakqdelvis ar
//
LOCUS       XP_054225829            1042 aa            linear   PRI 05-AUG-2025
DEFINITION  diacylglycerol lipase-alpha isoform X1 [Homo sapiens].
ACCESSION   XP_054225829
VERSION     XP_054225829.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369854.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1042
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1042
                     /product="diacylglycerol lipase-alpha isoform X1"
                     /calculated_mol_wt=114821
     Region          288..529
                     /region_name="Lipase_3"
                     /note="Lipase (class 3). Lipases are esterases that can
                     hydrolyze long-chain acyl-triglycerides into di- and
                     monoglycerides, glycerol, and free fatty acids at a
                     water/lipid interface. A typical feature of lipases is
                     'interfacial activation,' the process of...; cd00519"
                     /db_xref="CDD:238287"
     Site            order(400..401,403..411)
                     /site_type="active"
                     /note="active site flap/lid [active]"
                     /db_xref="CDD:238287"
     Site            470..474
                     /site_type="active"
                     /note="nucleophilic elbow [active]"
                     /db_xref="CDD:238287"
     CDS             1..1042
                     /gene="DAGLA"
                     /gene_synonym="C11orf11; DAGL(ALPHA); DAGLALPHA; NOC2;
                     NSDDR"
                     /coded_by="XM_054369854.1:67..3195"
                     /db_xref="GeneID:747"
                     /db_xref="HGNC:HGNC:1165"
                     /db_xref="MIM:614015"
ORIGIN      
        1 mpgivvfrrr wsvgsddlvl paiflfllht twfvilsvvl fglvynphea cslnlvdhgr
       61 gylgillscm iaemaiiwls mrggilytep rdsmqyvlyv rlailviefi yaivgivwlt
      121 qyytscndlt aknvtlgmvv cnwvvilsvc itvlcvfdpt grtfvklrat krrqrnlrty
      181 nlrhrleegq atswsrrlkv flcctrtkds qsdayseiay lfaeffrdld ivpsdiiagl
      241 vllrqrqrak rnavldeann dilaflsgmp vtrntkyldl knsqemlryk evcyymlfal
      301 aaygwpmylm rkpacglcql arscscclcp arprfapgvt ieednccgcn aiairrhfld
      361 enmtavdivy tschdavyet pfyvavdhdk kkvvisirgt lspkdaltdl tgdaerlpve
      421 ghhgtwlghk gmvlsaeyik kkleqemvls qafgrdlgrg tkhyglivvg hslgagtaai
      481 lsfllrpqyp tlkcfayspp ggllsedame yskefvtavv lgkdlvprig lsqlegfrrq
      541 lldvlqrstk pkwriivgat kcipkselpe evevttlast rlwthpsdlt ialsastply
      601 ppgriihvvh nhpaeqcccc eqeeptyfai wgdnkafnev iispamlheh lpyvvmegln
      661 kvlenynkgk tallsaakvm vsptevdltp elifqqqplp tgppmptgla lelptadhrn
      721 ssvrsksqse mslegfsegr llspvvaaaa rqdpvellll stqerlaael qarraplatm
      781 eslsdtesly sfdsrrssgf rsirgspslh avlerdeghl fyidpaipee npslssrtel
      841 laadslskhs qdtqpleaal gsggvtperp psaaandeee evggggggpa srgelalhng
      901 rlgdspspqv lefaefidsl fnldsksssf qdlycmvvpe sptsdyaegp kspsqqeill
      961 raqfepnlvp kpprlfagsa dpssgislsp sfplsssgel mdltptglss qeclaadkir
     1021 tstptghgas pakqdelvis ar
//
LOCUS       XP_054225830             956 aa            linear   PRI 05-AUG-2025
DEFINITION  diacylglycerol lipase-alpha isoform X2 [Homo sapiens].
ACCESSION   XP_054225830
VERSION     XP_054225830.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369855.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..956
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..956
                     /product="diacylglycerol lipase-alpha isoform X2"
                     /calculated_mol_wt=104907
     Region          202..443
                     /region_name="Lipase_3"
                     /note="Lipase (class 3). Lipases are esterases that can
                     hydrolyze long-chain acyl-triglycerides into di- and
                     monoglycerides, glycerol, and free fatty acids at a
                     water/lipid interface. A typical feature of lipases is
                     'interfacial activation,' the process of...; cd00519"
                     /db_xref="CDD:238287"
     Site            order(314..315,317..325)
                     /site_type="active"
                     /note="active site flap/lid [active]"
                     /db_xref="CDD:238287"
     Site            384..388
                     /site_type="active"
                     /note="nucleophilic elbow [active]"
                     /db_xref="CDD:238287"
     CDS             1..956
                     /gene="DAGLA"
                     /gene_synonym="C11orf11; DAGL(ALPHA); DAGLALPHA; NOC2;
                     NSDDR"
                     /coded_by="XM_054369855.1:205..3075"
                     /db_xref="GeneID:747"
                     /db_xref="HGNC:HGNC:1165"
                     /db_xref="MIM:614015"
ORIGIN      
        1 mtssyrpsss fscippailv iefiyaivgi vwltqyytsc ndltaknvtl gmvvcnwvvi
       61 lsvcitvlcv fdptgrtfvk lratkrrqrn lrtynlrhrl eegqatswsr rlkvflcctr
      121 tkdsqsdays eiaylfaeff rdldivpsdi iaglvllrqr qrakrnavld eanndilafl
      181 sgmpvtrntk yldlknsqem lrykevcyym lfalaaygwp mylmrkpacg lcqlarscsc
      241 clcparprfa pgvtieednc cgcnaiairr hfldenmtav divytschda vyetpfyvav
      301 dhdkkkvvis irgtlspkda ltdltgdaer lpveghhgtw lghkgmvlsa eyikkkleqe
      361 mvlsqafgrd lgrgtkhygl ivvghslgag taailsfllr pqyptlkcfa ysppggllse
      421 dameyskefv tavvlgkdlv priglsqleg frrqlldvlq rstkpkwrii vgatkcipks
      481 elpeevevtt lastrlwthp sdltialsas tplyppgrii hvvhnhpaeq cccceqeept
      541 yfaiwgdnka fneviispam lhehlpyvvm eglnkvleny nkgktallsa akvmvsptev
      601 dltpelifqq qplptgppmp tglalelpta dhrnssvrsk sqsemslegf segrllspvv
      661 aaaarqdpve llllstqerl aaelqarrap latmeslsdt eslysfdsrr ssgfrsirgs
      721 pslhavlerd eghlfyidpa ipeenpslss rtellaadsl skhsqdtqpl eaalgsggvt
      781 perppsaaan deeeevgggg ggpasrgela lhngrlgdsp spqvlefaef idslfnldsk
      841 sssfqdlycm vvpesptsdy aegpkspsqq eillraqfep nlvpkpprlf agsadpssgi
      901 slspsfplss sgelmdltpt glssqeclaa dkirtstptg hgaspakqde lvisar
//
LOCUS       XP_054225831             612 aa            linear   PRI 05-AUG-2025
DEFINITION  diacylglycerol lipase-alpha isoform X3 [Homo sapiens].
ACCESSION   XP_054225831
VERSION     XP_054225831.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369856.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..612
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..612
                     /product="diacylglycerol lipase-alpha isoform X3"
                     /calculated_mol_wt=68884
     Region          288..529
                     /region_name="Lipase_3"
                     /note="Lipase (class 3). Lipases are esterases that can
                     hydrolyze long-chain acyl-triglycerides into di- and
                     monoglycerides, glycerol, and free fatty acids at a
                     water/lipid interface. A typical feature of lipases is
                     'interfacial activation,' the process of...; cd00519"
                     /db_xref="CDD:238287"
     Site            order(400..401,403..411)
                     /site_type="active"
                     /note="active site flap/lid [active]"
                     /db_xref="CDD:238287"
     Site            470..474
                     /site_type="active"
                     /note="nucleophilic elbow [active]"
                     /db_xref="CDD:238287"
     CDS             1..612
                     /gene="DAGLA"
                     /gene_synonym="C11orf11; DAGL(ALPHA); DAGLALPHA; NOC2;
                     NSDDR"
                     /coded_by="XM_054369856.1:268..2106"
                     /db_xref="GeneID:747"
                     /db_xref="HGNC:HGNC:1165"
                     /db_xref="MIM:614015"
ORIGIN      
        1 mpgivvfrrr wsvgsddlvl paiflfllht twfvilsvvl fglvynphea cslnlvdhgr
       61 gylgillscm iaemaiiwls mrggilytep rdsmqyvlyv rlailviefi yaivgivwlt
      121 qyytscndlt aknvtlgmvv cnwvvilsvc itvlcvfdpt grtfvklrat krrqrnlrty
      181 nlrhrleegq atswsrrlkv flcctrtkds qsdayseiay lfaeffrdld ivpsdiiagl
      241 vllrqrqrak rnavldeann dilaflsgmp vtrntkyldl knsqemlryk evcyymlfal
      301 aaygwpmylm rkpacglcql arscscclcp arprfapgvt ieednccgcn aiairrhfld
      361 enmtavdivy tschdavyet pfyvavdhdk kkvvisirgt lspkdaltdl tgdaerlpve
      421 ghhgtwlghk gmvlsaeyik kkleqemvls qafgrdlgrg tkhyglivvg hslgagtaai
      481 lsfllrpqyp tlkcfayspp ggllsedame yskefvtavv lgkdlvprig lsqlegfrrq
      541 lldvlqrstk pkmrgwlgfq plaspeiqqf hvicpwhlig rlatvhlshc lfsggsswgp
      601 pnaspsrscl rr
//
LOCUS       XP_054225832             364 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Wnt-11 isoform X1 [Homo sapiens].
ACCESSION   XP_054225832
VERSION     XP_054225832.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369857.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..364
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..364
                     /product="protein Wnt-11 isoform X1"
                     /calculated_mol_wt=39997
     Region          51..364
                     /region_name="Wnt_Wnt11"
                     /note="Wnt domain found in protein Wnt-11 and similar
                     proteins; cd19343"
                     /db_xref="CDD:381717"
     Site            order(220..221,224..226,234,343,345,347,349)
                     /site_type="other"
                     /note="Frizzled receptor binding site [polypeptide
                     binding]"
                     /db_xref="CDD:381717"
     CDS             1..364
                     /gene="WNT11"
                     /gene_synonym="HWNT11"
                     /coded_by="XM_054369857.1:424..1518"
                     /db_xref="GeneID:7481"
                     /db_xref="HGNC:HGNC:12776"
                     /db_xref="MIM:603699"
ORIGIN      
        1 mrarpqvcea llfalalqtg vcygikwlal sktpsalaln qtqhckqleg lvsaqvqlcr
       61 snlelmhtvv haarevmkac rrafadmrwn cssielapny lldlerasad lplppsgtre
      121 safvyalsaa aishaiarac tsgdlpgcsc gpvpgeppgp gnrwggcadn lsygllmgak
      181 fsdapmkvkk tgsqanklmr lhnsevgrqa lraslemkck chgvsgscsi rtcwkglqel
      241 qdvaadlktr ylsatkvvhr pmgtrkhlvp kdldirpvkd selvylqssp dfcmknekvg
      301 shgtqdrqcn ktsngsdscd lmccgrgynp ytdrvverch ckyhwccyvt crrcertver
      361 yvck
//
LOCUS       XP_054225833             364 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Wnt-11 isoform X1 [Homo sapiens].
ACCESSION   XP_054225833
VERSION     XP_054225833.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369858.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..364
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..364
                     /product="protein Wnt-11 isoform X1"
                     /calculated_mol_wt=39997
     Region          51..364
                     /region_name="Wnt_Wnt11"
                     /note="Wnt domain found in protein Wnt-11 and similar
                     proteins; cd19343"
                     /db_xref="CDD:381717"
     Site            order(220..221,224..226,234,343,345,347,349)
                     /site_type="other"
                     /note="Frizzled receptor binding site [polypeptide
                     binding]"
                     /db_xref="CDD:381717"
     CDS             1..364
                     /gene="WNT11"
                     /gene_synonym="HWNT11"
                     /coded_by="XM_054369858.1:549..1643"
                     /db_xref="GeneID:7481"
                     /db_xref="HGNC:HGNC:12776"
                     /db_xref="MIM:603699"
ORIGIN      
        1 mrarpqvcea llfalalqtg vcygikwlal sktpsalaln qtqhckqleg lvsaqvqlcr
       61 snlelmhtvv haarevmkac rrafadmrwn cssielapny lldlerasad lplppsgtre
      121 safvyalsaa aishaiarac tsgdlpgcsc gpvpgeppgp gnrwggcadn lsygllmgak
      181 fsdapmkvkk tgsqanklmr lhnsevgrqa lraslemkck chgvsgscsi rtcwkglqel
      241 qdvaadlktr ylsatkvvhr pmgtrkhlvp kdldirpvkd selvylqssp dfcmknekvg
      301 shgtqdrqcn ktsngsdscd lmccgrgynp ytdrvverch ckyhwccyvt crrcertver
      361 yvck
//
LOCUS       XP_054225834             364 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Wnt-11 isoform X1 [Homo sapiens].
ACCESSION   XP_054225834
VERSION     XP_054225834.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369859.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..364
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..364
                     /product="protein Wnt-11 isoform X1"
                     /calculated_mol_wt=39997
     Region          51..364
                     /region_name="Wnt_Wnt11"
                     /note="Wnt domain found in protein Wnt-11 and similar
                     proteins; cd19343"
                     /db_xref="CDD:381717"
     Site            order(220..221,224..226,234,343,345,347,349)
                     /site_type="other"
                     /note="Frizzled receptor binding site [polypeptide
                     binding]"
                     /db_xref="CDD:381717"
     CDS             1..364
                     /gene="WNT11"
                     /gene_synonym="HWNT11"
                     /coded_by="XM_054369859.1:505..1599"
                     /db_xref="GeneID:7481"
                     /db_xref="HGNC:HGNC:12776"
                     /db_xref="MIM:603699"
ORIGIN      
        1 mrarpqvcea llfalalqtg vcygikwlal sktpsalaln qtqhckqleg lvsaqvqlcr
       61 snlelmhtvv haarevmkac rrafadmrwn cssielapny lldlerasad lplppsgtre
      121 safvyalsaa aishaiarac tsgdlpgcsc gpvpgeppgp gnrwggcadn lsygllmgak
      181 fsdapmkvkk tgsqanklmr lhnsevgrqa lraslemkck chgvsgscsi rtcwkglqel
      241 qdvaadlktr ylsatkvvhr pmgtrkhlvp kdldirpvkd selvylqssp dfcmknekvg
      301 shgtqdrqcn ktsngsdscd lmccgrgynp ytdrvverch ckyhwccyvt crrcertver
      361 yvck
//
LOCUS       XP_054225835             354 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Wnt-11 isoform X2 [Homo sapiens].
ACCESSION   XP_054225835
VERSION     XP_054225835.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369860.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..354
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..354
                     /product="protein Wnt-11 isoform X2"
                     /calculated_mol_wt=39048
     Region          51..354
                     /region_name="Wnt_Wnt11"
                     /note="Wnt domain found in protein Wnt-11 and similar
                     proteins; cd19343"
                     /db_xref="CDD:381717"
     Site            order(210..211,214..216,224,333,335,337,339)
                     /site_type="other"
                     /note="Frizzled receptor binding site [polypeptide
                     binding]"
                     /db_xref="CDD:381717"
     CDS             1..354
                     /gene="WNT11"
                     /gene_synonym="HWNT11"
                     /coded_by="XM_054369860.1:532..1596"
                     /db_xref="GeneID:7481"
                     /db_xref="HGNC:HGNC:12776"
                     /db_xref="MIM:603699"
ORIGIN      
        1 mrarpqvcea llfalalqtg vcygikwlal sktpsalaln qtqhckqleg lvsaqvqlcr
       61 snlelmhtvv haarevmkac rrafadmrwn cssielapny lldlergtre safvyalsaa
      121 aishaiarac tsgdlpgcsc gpvpgeppgp gnrwggcadn lsygllmgak fsdapmkvkk
      181 tgsqanklmr lhnsevgrqa lraslemkck chgvsgscsi rtcwkglqel qdvaadlktr
      241 ylsatkvvhr pmgtrkhlvp kdldirpvkd selvylqssp dfcmknekvg shgtqdrqcn
      301 ktsngsdscd lmccgrgynp ytdrvverch ckyhwccyvt crrcertver yvck
//
LOCUS       XP_054225836             354 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Wnt-11 isoform X2 [Homo sapiens].
ACCESSION   XP_054225836
VERSION     XP_054225836.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369861.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..354
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..354
                     /product="protein Wnt-11 isoform X2"
                     /calculated_mol_wt=39048
     Region          51..354
                     /region_name="Wnt_Wnt11"
                     /note="Wnt domain found in protein Wnt-11 and similar
                     proteins; cd19343"
                     /db_xref="CDD:381717"
     Site            order(210..211,214..216,224,333,335,337,339)
                     /site_type="other"
                     /note="Frizzled receptor binding site [polypeptide
                     binding]"
                     /db_xref="CDD:381717"
     CDS             1..354
                     /gene="WNT11"
                     /gene_synonym="HWNT11"
                     /coded_by="XM_054369861.1:407..1471"
                     /db_xref="GeneID:7481"
                     /db_xref="HGNC:HGNC:12776"
                     /db_xref="MIM:603699"
ORIGIN      
        1 mrarpqvcea llfalalqtg vcygikwlal sktpsalaln qtqhckqleg lvsaqvqlcr
       61 snlelmhtvv haarevmkac rrafadmrwn cssielapny lldlergtre safvyalsaa
      121 aishaiarac tsgdlpgcsc gpvpgeppgp gnrwggcadn lsygllmgak fsdapmkvkk
      181 tgsqanklmr lhnsevgrqa lraslemkck chgvsgscsi rtcwkglqel qdvaadlktr
      241 ylsatkvvhr pmgtrkhlvp kdldirpvkd selvylqssp dfcmknekvg shgtqdrqcn
      301 ktsngsdscd lmccgrgynp ytdrvverch ckyhwccyvt crrcertver yvck
//
LOCUS       XP_054225837             154 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Wnt-11 isoform X3 [Homo sapiens].
ACCESSION   XP_054225837
VERSION     XP_054225837.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369862.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..154
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..154
                     /product="protein Wnt-11 isoform X3"
                     /calculated_mol_wt=16445
     Region          51..>145
                     /region_name="Wnt"
                     /note="Wnt domain found in the WNT signaling gene family,
                     also called Wingless-type mouse mammary tumor virus (MMTV)
                     integration site family; cl38924"
                     /db_xref="CDD:393294"
     CDS             1..154
                     /gene="WNT11"
                     /gene_synonym="HWNT11"
                     /coded_by="XM_054369862.1:433..897"
                     /db_xref="GeneID:7481"
                     /db_xref="HGNC:HGNC:12776"
                     /db_xref="MIM:603699"
ORIGIN      
        1 mrarpqvcea llfalalqtg vcygikwlal sktpsalaln qtqhckqleg lvsaqvqlcr
       61 snlelmhtvv haarevmkac rrafadmrwn cssielapny lldlergtre safvyalsaa
      121 aishaiarac tsgdlpgcsc gpvpgsarls gnev
//
LOCUS       XP_054225838             363 aa            linear   PRI 05-AUG-2025
DEFINITION  citrate synthase-lysine N-methyltransferase CSKMT, mitochondrial
            isoform X1 [Homo sapiens].
ACCESSION   XP_054225838
VERSION     XP_054225838.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369863.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..363
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..363
                     /product="citrate synthase-lysine N-methyltransferase
                     CSKMT, mitochondrial isoform X1"
                     /calculated_mol_wt=38696
     Region          198..>330
                     /region_name="Methyltransf_31"
                     /note="Methyltransferase domain; pfam13847"
                     /db_xref="CDD:463998"
     CDS             1..363
                     /gene="CSKMT"
                     /gene_synonym="CS-KMT; METTL12; U99HG"
                     /coded_by="XM_054369863.1:204..1295"
                     /db_xref="GeneID:751071"
                     /db_xref="HGNC:HGNC:33113"
                     /db_xref="MIM:617897"
ORIGIN      
        1 mssvlaashp lvlssnagtp gisekdnrdp agssigvltl shlisglrtl ytllhfplqp
       61 ikavptivcv rvlfsgtaef geavrrlslr gicrsspgpq aspagvgwtl hisfsgrtyp
      121 nlqmaalrrm lhlpslmmgt crpfagslad scladrclwd rlhaqprlgt vptfdwffgy
      181 devqglllpl lqeaqaaspl rvldvgcgts slctglytks phpvdvlgvd fspvavahmn
      241 slleggpgqt plcpghpass lhfmhadaqn lgavassgsf qllldkgtwd avargglpra
      301 yqllseclrv lnpqgtliqf sdedpdvrlp cleqgsygwt vtvqelgpfr gityfayliq
      361 gsh
//
LOCUS       XP_054225839             730 aa            linear   PRI 05-AUG-2025
DEFINITION  splicing factor 1 isoform X1 [Homo sapiens].
ACCESSION   XP_054225839
VERSION     XP_054225839.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369864.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..730
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..730
                     /product="splicing factor 1 isoform X1"
                     /calculated_mol_wt=77630
     Region          142..382
                     /region_name="MSL5"
                     /note="Splicing factor (branch point binding protein) [RNA
                     processing and modification]; COG5176"
                     /db_xref="CDD:227503"
     Region          403..418
                     /region_name="ZnF_C2HC"
                     /note="zinc finger; smart00343"
                     /db_xref="CDD:197667"
     CDS             1..730
                     /gene="SF1"
                     /gene_synonym="BBP; D11S636; MBBP; ZCCHC25; ZFM1; ZNF162"
                     /coded_by="XM_054369864.1:151..2343"
                     /db_xref="GeneID:7536"
                     /db_xref="HGNC:HGNC:12950"
                     /db_xref="MIM:601516"
ORIGIN      
        1 matganatpl gklgppglpp lpgpkggfep gpppapgpga gllapgpppp ppvgsmgalt
       61 aafpfaalpp pppppppppp qqpppppppp spgasypppq pppppplyqr vsppqppppq
      121 pprkdqqpgp aggggdfpsk krkrsrwnqd tmeqktvipg mptvippglt reqerayivq
      181 lqiedltrkl rtgdlgippn pedrspspep iynsegkrln trefrtrkkl eeerhnlite
      241 mvalnpdfkp padykppatr vsdkvmipqd eypeinfvgl ligprgntlk niekecnaki
      301 mirgkgsvke gkvgrkdgqm lpgedeplha lvtantmenv kkaveqirni lkqgietped
      361 qndlrkmqlr elarlngtlr eddnrilrpw qssetrsitn ttvctkcgga ghiasdckfq
      421 rpgdpqsaqd karmdkeyls lmaelgeapv pasvgstsgp attplasapr paapannppp
      481 pslmsttqsr ppwmnsgpse srpyhgmhgg gpggpgggph sfphplpslt gghgghpmqh
      541 npngppppwm qpppppmnqg phppghhgpp pmvpgkyacg lwglspasrk rydaattygh
      601 daaaaaasqw aaptpslwss spmattaaaa satpsaqqqy gfqyplamaa kyddyhherw
      661 hrvhpamata aggcrsfsrs psdarqphyg apaprgpaas aawgpspsaa stawfrrhdd
      721 psprrrwpep
//
LOCUS       XP_054225841             733 aa            linear   PRI 05-AUG-2025
DEFINITION  splicing factor 1 isoform X3 [Homo sapiens].
ACCESSION   XP_054225841
VERSION     XP_054225841.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369866.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 9% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..733
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..733
                     /product="splicing factor 1 isoform X3"
                     /calculated_mol_wt=77902
     Region          142..382
                     /region_name="MSL5"
                     /note="Splicing factor (branch point binding protein) [RNA
                     processing and modification]; COG5176"
                     /db_xref="CDD:227503"
     Region          403..418
                     /region_name="ZnF_C2HC"
                     /note="zinc finger; smart00343"
                     /db_xref="CDD:197667"
     CDS             1..733
                     /gene="SF1"
                     /gene_synonym="BBP; D11S636; MBBP; ZCCHC25; ZFM1; ZNF162"
                     /coded_by="XM_054369866.1:151..2352"
                     /db_xref="GeneID:7536"
                     /db_xref="HGNC:HGNC:12950"
                     /db_xref="MIM:601516"
ORIGIN      
        1 matganatpl gklgppglpp lpgpkggfep gpppapgpga gllapgpppp ppvgsmgalt
       61 aafpfaalpp pppppppppp qqpppppppp spgasypppq pppppplyqr vsppqppppq
      121 pprkdqqpgp aggggdfpsk krkrsrwnqd tmeqktvipg mptvippglt reqerayivq
      181 lqiedltrkl rtgdlgippn pedrspspep iynsegkrln trefrtrkkl eeerhnlite
      241 mvalnpdfkp padykppatr vsdkvmipqd eypeinfvgl ligprgntlk niekecnaki
      301 mirgkgsvke gkvgrkdgqm lpgedeplha lvtantmenv kkaveqirni lkqgietped
      361 qndlrkmqlr elarlngtlr eddnrilrpw qssetrsitn ttvctkcgga ghiasdckfq
      421 rpgdpqsaqd karmdkeyls lmaelgeapv pasvgstsgp attplasapr paapannppp
      481 pslmsttqsr ppwmnsgpse srpyhgmhgg gpggpgggph sfphplpslt gghgghpmqh
      541 npngppppwm qpppppmnqg phppghhgpp pmgksvpgky acglwglspa srkrydaatt
      601 yghdaaaaaa sqwaaptpsl wssspmatta aaasatpsaq qqygfqypla maakyddyhh
      661 erwhrvhpam ataaggcrsf srspsdarqp hygapaprgp aasaawgpsp saastawfrr
      721 hddpsprrrw pep
//
LOCUS       XP_054225845             653 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 143 isoform X1 [Homo sapiens].
ACCESSION   XP_054225845
VERSION     XP_054225845.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369870.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..653
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..653
                     /product="zinc finger protein 143 isoform X1"
                     /calculated_mol_wt=70600
     Region          254..276
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(261,263,265,267..268,271..272,275,291,293,297..298,
                     301..302,305,321,323,325,327..328,331..332,335)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          <266..439
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          284..306
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          314..336
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          344..366
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          374..396
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          404..426
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          434..453
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..653
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /coded_by="XM_054369870.1:24..1985"
                     /db_xref="GeneID:7702"
                     /db_xref="HGNC:HGNC:12928"
                     /db_xref="MIM:603433"
ORIGIN      
        1 mvvgrrncwk ifsekmllaq inrdsqgmte fpgggmeaqh vtlclteavt vadgdnlenm
       61 egvslqavtl adgstayiqh nskdaklidg qviqledgsa ayvqhvpipk stgdslrled
      121 gqavqledgt tafihhtskd sydqsalqav qledgttayi hhavqvpqsd tilaiqadgt
      181 vaglhtgdat idpdtisale qyaakvsidg sesvagtgmi geneqekkmq ivlqghatrv
      241 taksqqsgek afrceydgcg klyttahhlk vhershtgdr pyqcehagcg kafatgyglk
      301 shvrthtgek pyrcsednct ksfktsgdlq khirthtger pfkcpfegcg rsfttsnirk
      361 vhvrthtger pyyctepgcg rafasatnyk nhvrihtgek pyvctvpgcd krfteyssly
      421 khhvvhthsk pyncnhcgkt ykqistlamh krtahndtep ieeeqeaffe pppgqgedvl
      481 kgsqityvtg vegddvvstq vatvtqsgls qqvtlisqdg tqhvnisqad mqaigntitm
      541 vtqdgtpitv pahdavissa gthsvamvta egtegqqvai vaqdlaafht assemghqqh
      601 shhlvttetr pltlvatsng tqiavqlgeq psleeairia sriqqgetpg ldd
//
LOCUS       XP_054225846             652 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 143 isoform X2 [Homo sapiens].
ACCESSION   XP_054225846
VERSION     XP_054225846.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369871.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..652
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..652
                     /product="zinc finger protein 143 isoform X2"
                     /calculated_mol_wt=70598
     Region          253..275
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(260,262,264,266..267,270..271,274,290,292,296..297,
                     300..301,304,320,322,324,326..327,330..331,334)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          <265..438
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          283..305
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          313..335
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          343..365
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          373..395
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          403..425
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          433..452
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..652
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /coded_by="XM_054369871.1:24..1982"
                     /db_xref="GeneID:7702"
                     /db_xref="HGNC:HGNC:12928"
                     /db_xref="MIM:603433"
ORIGIN      
        1 mvvgrrncwk ifsekmllaq inrdsqgmte fpgggmeaqh vtlclteavt vadgdnlenm
       61 egvslqavtl adgstayiqh nskdaklidg qviqledgsa ayvqhvpipk srdslrledg
      121 qavqledgtt afihhtskds ydqsalqavq ledgttayih havqvpqsdt ilaiqadgtv
      181 aglhtgdati dpdtisaleq yaakvsidgs esvagtgmig eneqekkmqi vlqghatrvt
      241 aksqqsgeka frceydgcgk lyttahhlkv hershtgdrp yqcehagcgk afatgyglks
      301 hvrthtgekp yrcsednctk sfktsgdlqk hirthtgerp fkcpfegcgr sfttsnirkv
      361 hvrthtgerp yyctepgcgr afasatnykn hvrihtgekp yvctvpgcdk rfteysslyk
      421 hhvvhthskp yncnhcgkty kqistlamhk rtahndtepi eeeqeaffep ppgqgedvlk
      481 gsqityvtgv egddvvstqv atvtqsglsq qvtlisqdgt qhvnisqadm qaigntitmv
      541 tqdgtpitvp ahdavissag thsvamvtae gtegqqvaiv aqdlaafhta ssemghqqhs
      601 hhlvttetrp ltlvatsngt qiavqlgeqp sleeairias riqqgetpgl dd
//
LOCUS       XP_054225847             622 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 143 isoform X3 [Homo sapiens].
ACCESSION   XP_054225847
VERSION     XP_054225847.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369872.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..622
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..622
                     /product="zinc finger protein 143 isoform X3"
                     /calculated_mol_wt=67339
     Region          223..245
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(230,232,234,236..237,240..241,244,260,262,266..267,
                     270..271,274,290,292,294,296..297,300..301,304)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          <235..408
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          253..275
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          283..305
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          313..335
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          343..365
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          373..395
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          403..422
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..622
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /coded_by="XM_054369872.1:24..1892"
                     /db_xref="GeneID:7702"
                     /db_xref="HGNC:HGNC:12928"
                     /db_xref="MIM:603433"
ORIGIN      
        1 mvvgrrncwk ifsekmllaq inrdsqgmte fpgggmeaqh vtlclteavt vadaklidgq
       61 viqledgsaa yvqhvpipks tgdslrledg qavqledgtt afihhtskds ydqsalqavq
      121 ledgttayih havqvpqsdt ilaiqadgtv aglhtgdati dpdtisaleq yaakvsidgs
      181 esvagtgmig eneqekkmqi vlqghatrvt aksqqsgeka frceydgcgk lyttahhlkv
      241 hershtgdrp yqcehagcgk afatgyglks hvrthtgekp yrcsednctk sfktsgdlqk
      301 hirthtgerp fkcpfegcgr sfttsnirkv hvrthtgerp yyctepgcgr afasatnykn
      361 hvrihtgekp yvctvpgcdk rfteysslyk hhvvhthskp yncnhcgkty kqistlamhk
      421 rtahndtepi eeeqeaffep ppgqgedvlk gsqityvtgv egddvvstqv atvtqsglsq
      481 qvtlisqdgt qhvnisqadm qaigntitmv tqdgtpitvp ahdavissag thsvamvtae
      541 gtegqqvaiv aqdlaafhta ssemghqqhs hhlvttetrp ltlvatsngt qiavqlgeqp
      601 sleeairias riqqgetpgl dd
//
LOCUS       XP_054225848             621 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 143 isoform X4 [Homo sapiens].
ACCESSION   XP_054225848
VERSION     XP_054225848.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369873.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..621
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..621
                     /product="zinc finger protein 143 isoform X4"
                     /calculated_mol_wt=67337
     Region          222..244
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(229,231,233,235..236,239..240,243,259,261,265..266,
                     269..270,273,289,291,293,295..296,299..300,303)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          <234..407
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          252..274
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          282..304
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          312..334
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          342..364
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          372..394
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          402..421
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..621
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /coded_by="XM_054369873.1:24..1889"
                     /db_xref="GeneID:7702"
                     /db_xref="HGNC:HGNC:12928"
                     /db_xref="MIM:603433"
ORIGIN      
        1 mvvgrrncwk ifsekmllaq inrdsqgmte fpgggmeaqh vtlclteavt vadaklidgq
       61 viqledgsaa yvqhvpipks rdslrledgq avqledgtta fihhtskdsy dqsalqavql
      121 edgttayihh avqvpqsdti laiqadgtva glhtgdatid pdtisaleqy aakvsidgse
      181 svagtgmige neqekkmqiv lqghatrvta ksqqsgekaf rceydgcgkl yttahhlkvh
      241 ershtgdrpy qcehagcgka fatgyglksh vrthtgekpy rcsednctks fktsgdlqkh
      301 irthtgerpf kcpfegcgrs fttsnirkvh vrthtgerpy yctepgcgra fasatnyknh
      361 vrihtgekpy vctvpgcdkr fteysslykh hvvhthskpy ncnhcgktyk qistlamhkr
      421 tahndtepie eeqeaffepp pgqgedvlkg sqityvtgve gddvvstqva tvtqsglsqq
      481 vtlisqdgtq hvnisqadmq aigntitmvt qdgtpitvpa hdavissagt hsvamvtaeg
      541 tegqqvaiva qdlaafhtas semghqqhsh hlvttetrpl tlvatsngtq iavqlgeqps
      601 leeairiasr iqqgetpgld d
//
LOCUS       XP_054225849             638 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 143 isoform X5 [Homo sapiens].
ACCESSION   XP_054225849
VERSION     XP_054225849.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369874.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..638
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..638
                     /product="zinc finger protein 143 isoform X5"
                     /calculated_mol_wt=68764
     Region          239..261
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(246,248,250,252..253,256..257,260,276,278,282..283,
                     286..287,290,306,308,310,312..313,316..317,320)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          <251..424
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          269..291
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          299..321
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          329..351
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          359..381
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          389..411
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          419..438
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..638
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /coded_by="XM_054369874.1:654..2570"
                     /db_xref="GeneID:7702"
                     /db_xref="HGNC:HGNC:12928"
                     /db_xref="MIM:603433"
ORIGIN      
        1 mllaqinrds qgmtefpggg meaqhvtlcl teavtvadgd nlenmegvsl qavtladgst
       61 ayiqhnskda klidgqviql edgsaayvqh vpipkstgds lrledgqavq ledgttafih
      121 htskdsydqs alqavqledg ttayihhavq vpqsdtilai qadgtvaglh tgdatidpdt
      181 isaleqyaak vsidgsesva gtgmigeneq ekkmqivlqg hatrvtaksq qsgekafrce
      241 ydgcgklytt ahhlkvhers htgdrpyqce hagcgkafat gyglkshvrt htgekpyrcs
      301 ednctksfkt sgdlqkhirt htgerpfkcp fegcgrsftt snirkvhvrt htgerpyyct
      361 epgcgrafas atnyknhvri htgekpyvct vpgcdkrfte ysslykhhvv hthskpyncn
      421 hcgktykqis tlamhkrtah ndtepieeeq eaffepppgq gedvlkgsqi tyvtgvegdd
      481 vvstqvatvt qsglsqqvtl isqdgtqhvn isqadmqaig ntitmvtqdg tpitvpahda
      541 vissagthsv amvtaegteg qqvaivaqdl aafhtassem ghqqhshhlv ttetrpltlv
      601 atsngtqiav qlgeqpslee airiasriqq getpgldd
//
LOCUS       XP_054225850             637 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 143 isoform X6 [Homo sapiens].
ACCESSION   XP_054225850
VERSION     XP_054225850.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369875.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..637
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..637
                     /product="zinc finger protein 143 isoform X6"
                     /calculated_mol_wt=68762
     Region          238..260
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(245,247,249,251..252,255..256,259,275,277,281..282,
                     285..286,289,305,307,309,311..312,315..316,319)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          <250..423
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          268..290
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          298..320
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          328..350
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          358..380
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          388..410
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          418..437
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..637
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /coded_by="XM_054369875.1:600..2513"
                     /db_xref="GeneID:7702"
                     /db_xref="HGNC:HGNC:12928"
                     /db_xref="MIM:603433"
ORIGIN      
        1 mllaqinrds qgmtefpggg meaqhvtlcl teavtvadgd nlenmegvsl qavtladgst
       61 ayiqhnskda klidgqviql edgsaayvqh vpipksrdsl rledgqavql edgttafihh
      121 tskdsydqsa lqavqledgt tayihhavqv pqsdtilaiq adgtvaglht gdatidpdti
      181 saleqyaakv sidgsesvag tgmigeneqe kkmqivlqgh atrvtaksqq sgekafrcey
      241 dgcgklytta hhlkvhersh tgdrpyqceh agcgkafatg yglkshvrth tgekpyrcse
      301 dnctksfkts gdlqkhirth tgerpfkcpf egcgrsftts nirkvhvrth tgerpyycte
      361 pgcgrafasa tnyknhvrih tgekpyvctv pgcdkrftey sslykhhvvh thskpyncnh
      421 cgktykqist lamhkrtahn dtepieeeqe affepppgqg edvlkgsqit yvtgvegddv
      481 vstqvatvtq sglsqqvtli sqdgtqhvni sqadmqaign titmvtqdgt pitvpahdav
      541 issagthsva mvtaegtegq qvaivaqdla afhtassemg hqqhshhlvt tetrpltlva
      601 tsngtqiavq lgeqpsleea iriasriqqg etpgldd
//
LOCUS       XP_054225851             638 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 143 isoform X5 [Homo sapiens].
ACCESSION   XP_054225851
VERSION     XP_054225851.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369876.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..638
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..638
                     /product="zinc finger protein 143 isoform X5"
                     /calculated_mol_wt=68764
     Region          239..261
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(246,248,250,252..253,256..257,260,276,278,282..283,
                     286..287,290,306,308,310,312..313,316..317,320)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          <251..424
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          269..291
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          299..321
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          329..351
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          359..381
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          389..411
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          419..438
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..638
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /coded_by="XM_054369876.1:850..2766"
                     /db_xref="GeneID:7702"
                     /db_xref="HGNC:HGNC:12928"
                     /db_xref="MIM:603433"
ORIGIN      
        1 mllaqinrds qgmtefpggg meaqhvtlcl teavtvadgd nlenmegvsl qavtladgst
       61 ayiqhnskda klidgqviql edgsaayvqh vpipkstgds lrledgqavq ledgttafih
      121 htskdsydqs alqavqledg ttayihhavq vpqsdtilai qadgtvaglh tgdatidpdt
      181 isaleqyaak vsidgsesva gtgmigeneq ekkmqivlqg hatrvtaksq qsgekafrce
      241 ydgcgklytt ahhlkvhers htgdrpyqce hagcgkafat gyglkshvrt htgekpyrcs
      301 ednctksfkt sgdlqkhirt htgerpfkcp fegcgrsftt snirkvhvrt htgerpyyct
      361 epgcgrafas atnyknhvri htgekpyvct vpgcdkrfte ysslykhhvv hthskpyncn
      421 hcgktykqis tlamhkrtah ndtepieeeq eaffepppgq gedvlkgsqi tyvtgvegdd
      481 vvstqvatvt qsglsqqvtl isqdgtqhvn isqadmqaig ntitmvtqdg tpitvpahda
      541 vissagthsv amvtaegteg qqvaivaqdl aafhtassem ghqqhshhlv ttetrpltlv
      601 atsngtqiav qlgeqpslee airiasriqq getpgldd
//
LOCUS       XP_054225852             638 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 143 isoform X5 [Homo sapiens].
ACCESSION   XP_054225852
VERSION     XP_054225852.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369877.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..638
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..638
                     /product="zinc finger protein 143 isoform X5"
                     /calculated_mol_wt=68764
     Region          239..261
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(246,248,250,252..253,256..257,260,276,278,282..283,
                     286..287,290,306,308,310,312..313,316..317,320)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          <251..424
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          269..291
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          299..321
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          329..351
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          359..381
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          389..411
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          419..438
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..638
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /coded_by="XM_054369877.1:939..2855"
                     /db_xref="GeneID:7702"
                     /db_xref="HGNC:HGNC:12928"
                     /db_xref="MIM:603433"
ORIGIN      
        1 mllaqinrds qgmtefpggg meaqhvtlcl teavtvadgd nlenmegvsl qavtladgst
       61 ayiqhnskda klidgqviql edgsaayvqh vpipkstgds lrledgqavq ledgttafih
      121 htskdsydqs alqavqledg ttayihhavq vpqsdtilai qadgtvaglh tgdatidpdt
      181 isaleqyaak vsidgsesva gtgmigeneq ekkmqivlqg hatrvtaksq qsgekafrce
      241 ydgcgklytt ahhlkvhers htgdrpyqce hagcgkafat gyglkshvrt htgekpyrcs
      301 ednctksfkt sgdlqkhirt htgerpfkcp fegcgrsftt snirkvhvrt htgerpyyct
      361 epgcgrafas atnyknhvri htgekpyvct vpgcdkrfte ysslykhhvv hthskpyncn
      421 hcgktykqis tlamhkrtah ndtepieeeq eaffepppgq gedvlkgsqi tyvtgvegdd
      481 vvstqvatvt qsglsqqvtl isqdgtqhvn isqadmqaig ntitmvtqdg tpitvpahda
      541 vissagthsv amvtaegteg qqvaivaqdl aafhtassem ghqqhshhlv ttetrpltlv
      601 atsngtqiav qlgeqpslee airiasriqq getpgldd
//
LOCUS       XP_054225853             638 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 143 isoform X5 [Homo sapiens].
ACCESSION   XP_054225853
VERSION     XP_054225853.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369878.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..638
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..638
                     /product="zinc finger protein 143 isoform X5"
                     /calculated_mol_wt=68764
     Region          239..261
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(246,248,250,252..253,256..257,260,276,278,282..283,
                     286..287,290,306,308,310,312..313,316..317,320)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          <251..424
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          269..291
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          299..321
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          329..351
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          359..381
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          389..411
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          419..438
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..638
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /coded_by="XM_054369878.1:600..2516"
                     /db_xref="GeneID:7702"
                     /db_xref="HGNC:HGNC:12928"
                     /db_xref="MIM:603433"
ORIGIN      
        1 mllaqinrds qgmtefpggg meaqhvtlcl teavtvadgd nlenmegvsl qavtladgst
       61 ayiqhnskda klidgqviql edgsaayvqh vpipkstgds lrledgqavq ledgttafih
      121 htskdsydqs alqavqledg ttayihhavq vpqsdtilai qadgtvaglh tgdatidpdt
      181 isaleqyaak vsidgsesva gtgmigeneq ekkmqivlqg hatrvtaksq qsgekafrce
      241 ydgcgklytt ahhlkvhers htgdrpyqce hagcgkafat gyglkshvrt htgekpyrcs
      301 ednctksfkt sgdlqkhirt htgerpfkcp fegcgrsftt snirkvhvrt htgerpyyct
      361 epgcgrafas atnyknhvri htgekpyvct vpgcdkrfte ysslykhhvv hthskpyncn
      421 hcgktykqis tlamhkrtah ndtepieeeq eaffepppgq gedvlkgsqi tyvtgvegdd
      481 vvstqvatvt qsglsqqvtl isqdgtqhvn isqadmqaig ntitmvtqdg tpitvpahda
      541 vissagthsv amvtaegteg qqvaivaqdl aafhtassem ghqqhshhlv ttetrpltlv
      601 atsngtqiav qlgeqpslee airiasriqq getpgldd
//
LOCUS       XP_054225854             638 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 143 isoform X5 [Homo sapiens].
ACCESSION   XP_054225854
VERSION     XP_054225854.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369879.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..638
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..638
                     /product="zinc finger protein 143 isoform X5"
                     /calculated_mol_wt=68764
     Region          239..261
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(246,248,250,252..253,256..257,260,276,278,282..283,
                     286..287,290,306,308,310,312..313,316..317,320)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          <251..424
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          269..291
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          299..321
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          329..351
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          359..381
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          389..411
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          419..438
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..638
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /coded_by="XM_054369879.1:201..2117"
                     /db_xref="GeneID:7702"
                     /db_xref="HGNC:HGNC:12928"
                     /db_xref="MIM:603433"
ORIGIN      
        1 mllaqinrds qgmtefpggg meaqhvtlcl teavtvadgd nlenmegvsl qavtladgst
       61 ayiqhnskda klidgqviql edgsaayvqh vpipkstgds lrledgqavq ledgttafih
      121 htskdsydqs alqavqledg ttayihhavq vpqsdtilai qadgtvaglh tgdatidpdt
      181 isaleqyaak vsidgsesva gtgmigeneq ekkmqivlqg hatrvtaksq qsgekafrce
      241 ydgcgklytt ahhlkvhers htgdrpyqce hagcgkafat gyglkshvrt htgekpyrcs
      301 ednctksfkt sgdlqkhirt htgerpfkcp fegcgrsftt snirkvhvrt htgerpyyct
      361 epgcgrafas atnyknhvri htgekpyvct vpgcdkrfte ysslykhhvv hthskpyncn
      421 hcgktykqis tlamhkrtah ndtepieeeq eaffepppgq gedvlkgsqi tyvtgvegdd
      481 vvstqvatvt qsglsqqvtl isqdgtqhvn isqadmqaig ntitmvtqdg tpitvpahda
      541 vissagthsv amvtaegteg qqvaivaqdl aafhtassem ghqqhshhlv ttetrpltlv
      601 atsngtqiav qlgeqpslee airiasriqq getpgldd
//
LOCUS       XP_054225855             637 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 143 isoform X6 [Homo sapiens].
ACCESSION   XP_054225855
VERSION     XP_054225855.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369880.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..637
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..637
                     /product="zinc finger protein 143 isoform X6"
                     /calculated_mol_wt=68762
     Region          238..260
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(245,247,249,251..252,255..256,259,275,277,281..282,
                     285..286,289,305,307,309,311..312,315..316,319)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          <250..423
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          268..290
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          298..320
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          328..350
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          358..380
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          388..410
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          418..437
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..637
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /coded_by="XM_054369880.1:839..2752"
                     /db_xref="GeneID:7702"
                     /db_xref="HGNC:HGNC:12928"
                     /db_xref="MIM:603433"
ORIGIN      
        1 mllaqinrds qgmtefpggg meaqhvtlcl teavtvadgd nlenmegvsl qavtladgst
       61 ayiqhnskda klidgqviql edgsaayvqh vpipksrdsl rledgqavql edgttafihh
      121 tskdsydqsa lqavqledgt tayihhavqv pqsdtilaiq adgtvaglht gdatidpdti
      181 saleqyaakv sidgsesvag tgmigeneqe kkmqivlqgh atrvtaksqq sgekafrcey
      241 dgcgklytta hhlkvhersh tgdrpyqceh agcgkafatg yglkshvrth tgekpyrcse
      301 dnctksfkts gdlqkhirth tgerpfkcpf egcgrsftts nirkvhvrth tgerpyycte
      361 pgcgrafasa tnyknhvrih tgekpyvctv pgcdkrftey sslykhhvvh thskpyncnh
      421 cgktykqist lamhkrtahn dtepieeeqe affepppgqg edvlkgsqit yvtgvegddv
      481 vstqvatvtq sglsqqvtli sqdgtqhvni sqadmqaign titmvtqdgt pitvpahdav
      541 issagthsva mvtaegtegq qvaivaqdla afhtassemg hqqhshhlvt tetrpltlva
      601 tsngtqiavq lgeqpsleea iriasriqqg etpgldd
//
LOCUS       XP_054225856             637 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 143 isoform X6 [Homo sapiens].
ACCESSION   XP_054225856
VERSION     XP_054225856.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369881.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..637
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..637
                     /product="zinc finger protein 143 isoform X6"
                     /calculated_mol_wt=68762
     Region          238..260
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(245,247,249,251..252,255..256,259,275,277,281..282,
                     285..286,289,305,307,309,311..312,315..316,319)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          <250..423
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          268..290
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          298..320
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          328..350
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          358..380
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          388..410
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          418..437
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..637
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /coded_by="XM_054369881.1:966..2879"
                     /db_xref="GeneID:7702"
                     /db_xref="HGNC:HGNC:12928"
                     /db_xref="MIM:603433"
ORIGIN      
        1 mllaqinrds qgmtefpggg meaqhvtlcl teavtvadgd nlenmegvsl qavtladgst
       61 ayiqhnskda klidgqviql edgsaayvqh vpipksrdsl rledgqavql edgttafihh
      121 tskdsydqsa lqavqledgt tayihhavqv pqsdtilaiq adgtvaglht gdatidpdti
      181 saleqyaakv sidgsesvag tgmigeneqe kkmqivlqgh atrvtaksqq sgekafrcey
      241 dgcgklytta hhlkvhersh tgdrpyqceh agcgkafatg yglkshvrth tgekpyrcse
      301 dnctksfkts gdlqkhirth tgerpfkcpf egcgrsftts nirkvhvrth tgerpyycte
      361 pgcgrafasa tnyknhvrih tgekpyvctv pgcdkrftey sslykhhvvh thskpyncnh
      421 cgktykqist lamhkrtahn dtepieeeqe affepppgqg edvlkgsqit yvtgvegddv
      481 vstqvatvtq sglsqqvtli sqdgtqhvni sqadmqaign titmvtqdgt pitvpahdav
      541 issagthsva mvtaegtegq qvaivaqdla afhtassemg hqqhshhlvt tetrpltlva
      601 tsngtqiavq lgeqpsleea iriasriqqg etpgldd
//
LOCUS       XP_054225857             637 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 143 isoform X6 [Homo sapiens].
ACCESSION   XP_054225857
VERSION     XP_054225857.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369882.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..637
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..637
                     /product="zinc finger protein 143 isoform X6"
                     /calculated_mol_wt=68762
     Region          238..260
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(245,247,249,251..252,255..256,259,275,277,281..282,
                     285..286,289,305,307,309,311..312,315..316,319)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          <250..423
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          268..290
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          298..320
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          328..350
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          358..380
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          388..410
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          418..437
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..637
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /coded_by="XM_054369882.1:201..2114"
                     /db_xref="GeneID:7702"
                     /db_xref="HGNC:HGNC:12928"
                     /db_xref="MIM:603433"
ORIGIN      
        1 mllaqinrds qgmtefpggg meaqhvtlcl teavtvadgd nlenmegvsl qavtladgst
       61 ayiqhnskda klidgqviql edgsaayvqh vpipksrdsl rledgqavql edgttafihh
      121 tskdsydqsa lqavqledgt tayihhavqv pqsdtilaiq adgtvaglht gdatidpdti
      181 saleqyaakv sidgsesvag tgmigeneqe kkmqivlqgh atrvtaksqq sgekafrcey
      241 dgcgklytta hhlkvhersh tgdrpyqceh agcgkafatg yglkshvrth tgekpyrcse
      301 dnctksfkts gdlqkhirth tgerpfkcpf egcgrsftts nirkvhvrth tgerpyycte
      361 pgcgrafasa tnyknhvrih tgekpyvctv pgcdkrftey sslykhhvvh thskpyncnh
      421 cgktykqist lamhkrtahn dtepieeeqe affepppgqg edvlkgsqit yvtgvegddv
      481 vstqvatvtq sglsqqvtli sqdgtqhvni sqadmqaign titmvtqdgt pitvpahdav
      541 issagthsva mvtaegtegq qvaivaqdla afhtassemg hqqhshhlvt tetrpltlva
      601 tsngtqiavq lgeqpsleea iriasriqqg etpgldd
//
LOCUS       XP_054225858             606 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 143 isoform X7 [Homo sapiens].
ACCESSION   XP_054225858
VERSION     XP_054225858.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369883.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..606
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..606
                     /product="zinc finger protein 143 isoform X7"
                     /calculated_mol_wt=65502
     Region          207..229
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(214,216,218,220..221,224..225,228,244,246,250..251,
                     254..255,258,274,276,278,280..281,284..285,288)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          <219..392
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          237..259
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          267..289
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          297..319
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          327..349
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          357..379
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          387..406
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..606
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /coded_by="XM_054369883.1:116..1936"
                     /db_xref="GeneID:7702"
                     /db_xref="HGNC:HGNC:12928"
                     /db_xref="MIM:603433"
ORIGIN      
        1 mllaqinrds qgmtefpggg meaqhvtlcl teavtvadak lidgqviqle dgsaayvqhv
       61 pipksrdslr ledgqavqle dgttafihht skdsydqsal qavqledgtt ayihhavqvp
      121 qsdtilaiqa dgtvaglhtg datidpdtis aleqyaakvs idgsesvagt gmigeneqek
      181 kmqivlqgha trvtaksqqs gekafrceyd gcgklyttah hlkvhersht gdrpyqceha
      241 gcgkafatgy glkshvrtht gekpyrcsed nctksfktsg dlqkhirtht gerpfkcpfe
      301 gcgrsfttsn irkvhvrtht gerpyyctep gcgrafasat nyknhvriht gekpyvctvp
      361 gcdkrfteys slykhhvvht hskpyncnhc gktykqistl amhkrtahnd tepieeeqea
      421 ffepppgqge dvlkgsqity vtgvegddvv stqvatvtqs glsqqvtlis qdgtqhvnis
      481 qadmqaignt itmvtqdgtp itvpahdavi ssagthsvam vtaegtegqq vaivaqdlaa
      541 fhtassemgh qqhshhlvtt etrpltlvat sngtqiavql geqpsleeai riasriqqge
      601 tpgldd
//
LOCUS       XP_054225859             606 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 143 isoform X7 [Homo sapiens].
ACCESSION   XP_054225859
VERSION     XP_054225859.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369884.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..606
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..606
                     /product="zinc finger protein 143 isoform X7"
                     /calculated_mol_wt=65502
     Region          207..229
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(214,216,218,220..221,224..225,228,244,246,250..251,
                     254..255,258,274,276,278,280..281,284..285,288)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          <219..392
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          237..259
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          267..289
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          297..319
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          327..349
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          357..379
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          387..406
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..606
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /coded_by="XM_054369884.1:839..2659"
                     /db_xref="GeneID:7702"
                     /db_xref="HGNC:HGNC:12928"
                     /db_xref="MIM:603433"
ORIGIN      
        1 mllaqinrds qgmtefpggg meaqhvtlcl teavtvadak lidgqviqle dgsaayvqhv
       61 pipksrdslr ledgqavqle dgttafihht skdsydqsal qavqledgtt ayihhavqvp
      121 qsdtilaiqa dgtvaglhtg datidpdtis aleqyaakvs idgsesvagt gmigeneqek
      181 kmqivlqgha trvtaksqqs gekafrceyd gcgklyttah hlkvhersht gdrpyqceha
      241 gcgkafatgy glkshvrtht gekpyrcsed nctksfktsg dlqkhirtht gerpfkcpfe
      301 gcgrsfttsn irkvhvrtht gerpyyctep gcgrafasat nyknhvriht gekpyvctvp
      361 gcdkrfteys slykhhvvht hskpyncnhc gktykqistl amhkrtahnd tepieeeqea
      421 ffepppgqge dvlkgsqity vtgvegddvv stqvatvtqs glsqqvtlis qdgtqhvnis
      481 qadmqaignt itmvtqdgtp itvpahdavi ssagthsvam vtaegtegqq vaivaqdlaa
      541 fhtassemgh qqhshhlvtt etrpltlvat sngtqiavql geqpsleeai riasriqqge
      601 tpgldd
//
LOCUS       XP_054225860             606 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 143 isoform X7 [Homo sapiens].
ACCESSION   XP_054225860
VERSION     XP_054225860.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369885.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..606
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..606
                     /product="zinc finger protein 143 isoform X7"
                     /calculated_mol_wt=65502
     Region          207..229
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(214,216,218,220..221,224..225,228,244,246,250..251,
                     254..255,258,274,276,278,280..281,284..285,288)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          <219..392
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          237..259
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          267..289
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          297..319
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          327..349
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          357..379
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          387..406
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..606
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /coded_by="XM_054369885.1:600..2420"
                     /db_xref="GeneID:7702"
                     /db_xref="HGNC:HGNC:12928"
                     /db_xref="MIM:603433"
ORIGIN      
        1 mllaqinrds qgmtefpggg meaqhvtlcl teavtvadak lidgqviqle dgsaayvqhv
       61 pipksrdslr ledgqavqle dgttafihht skdsydqsal qavqledgtt ayihhavqvp
      121 qsdtilaiqa dgtvaglhtg datidpdtis aleqyaakvs idgsesvagt gmigeneqek
      181 kmqivlqgha trvtaksqqs gekafrceyd gcgklyttah hlkvhersht gdrpyqceha
      241 gcgkafatgy glkshvrtht gekpyrcsed nctksfktsg dlqkhirtht gerpfkcpfe
      301 gcgrsfttsn irkvhvrtht gerpyyctep gcgrafasat nyknhvriht gekpyvctvp
      361 gcdkrfteys slykhhvvht hskpyncnhc gktykqistl amhkrtahnd tepieeeqea
      421 ffepppgqge dvlkgsqity vtgvegddvv stqvatvtqs glsqqvtlis qdgtqhvnis
      481 qadmqaignt itmvtqdgtp itvpahdavi ssagthsvam vtaegtegqq vaivaqdlaa
      541 fhtassemgh qqhshhlvtt etrpltlvat sngtqiavql geqpsleeai riasriqqge
      601 tpgldd
//
LOCUS       XP_054225861             435 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 143 isoform X8 [Homo sapiens].
ACCESSION   XP_054225861
VERSION     XP_054225861.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369886.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..435
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..435
                     /product="zinc finger protein 143 isoform X8"
                     /calculated_mol_wt=47564
     Region          36..58
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(43,45,47,49..50,53..54,57,73,75,79..80,83..84,87,
                     103,105,107,109..110,113..114,117)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          <48..221
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          66..88
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          96..118
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          126..148
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          156..178
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          186..208
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          216..235
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..435
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /coded_by="XM_054369886.1:572..1879"
                     /db_xref="GeneID:7702"
                     /db_xref="HGNC:HGNC:12928"
                     /db_xref="MIM:603433"
ORIGIN      
        1 migeneqekk mqivlqghat rvtaksqqsg ekafrceydg cgklyttahh lkvhershtg
       61 drpyqcehag cgkafatgyg lkshvrthtg ekpyrcsedn ctksfktsgd lqkhirthtg
      121 erpfkcpfeg cgrsfttsni rkvhvrthtg erpyyctepg cgrafasatn yknhvrihtg
      181 ekpyvctvpg cdkrfteyss lykhhvvhth skpyncnhcg ktykqistla mhkrtahndt
      241 epieeeqeaf fepppgqged vlkgsqityv tgvegddvvs tqvatvtqsg lsqqvtlisq
      301 dgtqhvnisq admqaignti tmvtqdgtpi tvpahdavis sagthsvamv taegtegqqv
      361 aivaqdlaaf htassemghq qhshhlvtte trpltlvats ngtqiavqlg eqpsleeair
      421 iasriqqget pgldd
//
LOCUS       XP_054225862             435 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 143 isoform X8 [Homo sapiens].
ACCESSION   XP_054225862
VERSION     XP_054225862.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369887.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..435
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..435
                     /product="zinc finger protein 143 isoform X8"
                     /calculated_mol_wt=47564
     Region          36..58
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(43,45,47,49..50,53..54,57,73,75,79..80,83..84,87,
                     103,105,107,109..110,113..114,117)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          <48..221
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          66..88
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          96..118
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          126..148
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          156..178
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          186..208
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          216..235
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..435
                     /gene="ZNF143"
                     /gene_synonym="pHZ-1; SBF; STAF"
                     /coded_by="XM_054369887.1:569..1876"
                     /db_xref="GeneID:7702"
                     /db_xref="HGNC:HGNC:12928"
                     /db_xref="MIM:603433"
ORIGIN      
        1 migeneqekk mqivlqghat rvtaksqqsg ekafrceydg cgklyttahh lkvhershtg
       61 drpyqcehag cgkafatgyg lkshvrthtg ekpyrcsedn ctksfktsgd lqkhirthtg
      121 erpfkcpfeg cgrsfttsni rkvhvrthtg erpyyctepg cgrafasatn yknhvrihtg
      181 ekpyvctvpg cdkrfteyss lykhhvvhth skpyncnhcg ktykqistla mhkrtahndt
      241 epieeeqeaf fepppgqged vlkgsqityv tgvegddvvs tqvatvtqsg lsqqvtlisq
      301 dgtqhvnisq admqaignti tmvtqdgtpi tvpahdavis sagthsvamv taegtegqqv
      361 aivaqdlaaf htassemghq qhshhlvtte trpltlvats ngtqiavqlg eqpsleeair
      421 iasriqqget pgldd
//
LOCUS       XP_054225863             673 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger and BTB domain-containing protein 16 isoform X3 [Homo
            sapiens].
ACCESSION   XP_054225863
VERSION     XP_054225863.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369888.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..673
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..673
                     /product="zinc finger and BTB domain-containing protein 16
                     isoform X3"
                     /calculated_mol_wt=74143
     Region          16..122
                     /region_name="BTB_POZ_ZBTB16_PLZF"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 16 (ZBTB16); cd18205"
                     /db_xref="CDD:349514"
     Region          177..>327
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          406..426
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          434..454
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          <448..622
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          463..483
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          492..512
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          520..540
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(525,527,529,531..532,535..536,539,553,555,559..560,
                     563..564,567,581,583,585,587..588,591..592,595)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          548..568
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          576..596
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          604..624
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          632..652
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..673
                     /gene="ZBTB16"
                     /gene_synonym="PLZF; ZNF145"
                     /coded_by="XM_054369888.1:705..2726"
                     /db_xref="GeneID:7704"
                     /db_xref="HGNC:HGNC:12930"
                     /db_xref="MIM:176797"
ORIGIN      
        1 mdltkmgmiq lqnpshptgl lckanqmrla gtlcdvvimv dsqefhahrt vlactskmfe
       61 ilfhrnsqhy tldflspktf qqileyayta tlqakaedld dllyaaeile ieyleeqclk
      121 mletiqasdd ndteatmadg gaeeeedrka rylknifisk hsseesgyas vagqslpgpm
      181 vdqspsvsts fglsamsptk aavdslmtig qsllqgtlqp pagpeeptla gggrhpgvae
      241 vktemmqvde vpsqdspgaa essisggmgd kveergkegp gtptrssvit sarelhygre
      301 esaeqvpppa eagqaptgrp ehpapppekh lgiysvlpnh kadavlsmps svtsglhvqp
      361 alavsmdfst yggllpqgfi qrelfsklge lavgmksesr tigeqcsvcg velpdneave
      421 qhrklhsgmk tygcelcgkr fldslrlrmh llahsagaka fvcdqcgaqf skedalethr
      481 qthtgtdmav fcllcgkrfq aqsalqqhme vhagvrsyic secnrtfpsh talkrhlrsh
      541 tgdhpyecef cgscfrdest lkshkrihtg ekpyecngcg kkfslkhqle thyrvhtgek
      601 pfecklchqr srdysamikh lrthngaspy qcticteycp slssmqkhmk ghkpeeippd
      661 wriektylyl cyv
//
LOCUS       XP_054225864             485 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger and BTB domain-containing protein 16 isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225864
VERSION     XP_054225864.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369889.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..485
                     /product="zinc finger and BTB domain-containing protein 16
                     isoform X1"
                     /calculated_mol_wt=52243
     Region          16..122
                     /region_name="BTB_POZ_ZBTB16_PLZF"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 16 (ZBTB16); cd18205"
                     /db_xref="CDD:349514"
     Region          406..426
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(411,413,415,417..418,421..422,425,439,441,445..446,
                     449..450,453,468,470,472,474..475,478..479,482)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          434..454
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          460..483
                     /region_name="zf-C2H2_6"
                     /note="C2H2-type zinc finger; pfam13912"
                     /db_xref="CDD:433576"
     Region          463..483
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..485
                     /gene="ZBTB16"
                     /gene_synonym="PLZF; ZNF145"
                     /coded_by="XM_054369889.1:263..1720"
                     /db_xref="GeneID:7704"
                     /db_xref="HGNC:HGNC:12930"
                     /db_xref="MIM:176797"
ORIGIN      
        1 mdltkmgmiq lqnpshptgl lckanqmrla gtlcdvvimv dsqefhahrt vlactskmfe
       61 ilfhrnsqhy tldflspktf qqileyayta tlqakaedld dllyaaeile ieyleeqclk
      121 mletiqasdd ndteatmadg gaeeeedrka rylknifisk hsseesgyas vagqslpgpm
      181 vdqspsvsts fglsamsptk aavdslmtig qsllqgtlqp pagpeeptla gggrhpgvae
      241 vktemmqvde vpsqdspgaa essisggmgd kveergkegp gtptrssvit sarelhygre
      301 esaeqvpppa eagqaptgrp ehpapppekh lgiysvlpnh kadavlsmps svtsglhvqp
      361 alavsmdfst yggllpqgfi qrelfsklge lavgmksesr tigeqcsvcg velpdneave
      421 qhrklhsgmk tygcelcgkr fldslrlrmh llahsagaka fvcdqcgaqf skedalethr
      481 qthtg
//
LOCUS       XP_054225865             425 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger and BTB domain-containing protein 16 isoform X2 [Homo
            sapiens].
ACCESSION   XP_054225865
VERSION     XP_054225865.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369890.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..425
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..425
                     /product="zinc finger and BTB domain-containing protein 16
                     isoform X2"
                     /calculated_mol_wt=45615
     Region          16..122
                     /region_name="BTB_POZ_ZBTB16_PLZF"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 16 (ZBTB16); cd18205"
                     /db_xref="CDD:349514"
     CDS             1..425
                     /gene="ZBTB16"
                     /gene_synonym="PLZF; ZNF145"
                     /coded_by="XM_054369890.1:263..1540"
                     /db_xref="GeneID:7704"
                     /db_xref="HGNC:HGNC:12930"
                     /db_xref="MIM:176797"
ORIGIN      
        1 mdltkmgmiq lqnpshptgl lckanqmrla gtlcdvvimv dsqefhahrt vlactskmfe
       61 ilfhrnsqhy tldflspktf qqileyayta tlqakaedld dllyaaeile ieyleeqclk
      121 mletiqasdd ndteatmadg gaeeeedrka rylknifisk hsseesgyas vagqslpgpm
      181 vdqspsvsts fglsamsptk aavdslmtig qsllqgtlqp pagpeeptla gggrhpgvae
      241 vktemmqvde vpsqdspgaa essisggmgd kveergkegp gtptrssvit sarelhygre
      301 esaeqvpppa eagqaptgrp ehpapppekh lgiysvlpnh kadavlsmps svtsglhvqp
      361 alavsmdfst yggllpqgfi qrelfsklge lavgmksesr tigeqcsvcg velpdneave
      421 qhrvf
//
LOCUS       XP_054225866             648 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 202 isoform X1 [Homo sapiens].
ACCESSION   XP_054225866
VERSION     XP_054225866.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369891.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..648
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..648
                     /product="zinc finger protein 202 isoform X1"
                     /calculated_mol_wt=74561
     Region          43..154
                     /region_name="SCAN"
                     /note="leucine rich region; smart00431"
                     /db_xref="CDD:128708"
     Region          237..297
                     /region_name="KRAB"
                     /note="krueppel associated box; smart00349"
                     /db_xref="CDD:214630"
     Region          397..>644
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          399..419
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(404,406,408,410..411,414..415,418,432,434,438..439,
                     442..443,446,488,490,492,494..495,498..499,502)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          427..447
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          483..503
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          511..531
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          539..559
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          567..587
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(572,574,576,578..579,582..583,586,600,602,606..607,
                     610..611,614,628,630,632,634..635,638..639,642)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          595..615
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          623..643
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..648
                     /gene="ZNF202"
                     /gene_synonym="ZKSCAN10; ZSCAN42"
                     /coded_by="XM_054369891.1:630..2576"
                     /db_xref="GeneID:7753"
                     /db_xref="HGNC:HGNC:12994"
                     /db_xref="MIM:603430"
ORIGIN      
        1 matavepedq dlweeegilm vkleddftcr pesvlqrddp vletshqnfr rfryqeaasp
       61 realirlrel chqwlrperr tkeqilellv leqfltvlpg elqswvrgqr pesgeeavtl
      121 veglqkqprr prrwvtvhvh gqevlseetv hlgaepespn elqdpvqsst peqspeettq
      181 spdlgapaeq rphqeeelqt lqesevpvpe dpdlpaerss gdsemvallt alsqglvtfk
      241 dvavcfsqdq wsdldptqke fygeyvleed cgivvslsfp iprpdeisqv reeepwvpdi
      301 qepqetqepe ilsftytgdr skdeeecleq edlsledihr pvlgepeihq tpdweivfed
      361 npgrlnerrf gtnisqvnsf vnlrettpvh pllgrhhdcs vcgksftcns hlvrhlrtht
      421 gekpykcmec gksytrsshl arhqkvhkmn apykyplnrk nleetspvtq aertpsvekp
      481 yrcddcgkhf rwtsdlvrhq rthtgekpff cticgksfsq ksvltthqri hlggkpylcg
      541 ecgedfsehr rylahrktha aeelylcsec grcfthsaaf akhlrghasv rpcrcnecgk
      601 sfsrrdhlvr hqrthtgekp ftcptcgksf srgyhlirhq rthsekts
//
LOCUS       XP_054225867             648 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 202 isoform X1 [Homo sapiens].
ACCESSION   XP_054225867
VERSION     XP_054225867.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369892.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..648
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..648
                     /product="zinc finger protein 202 isoform X1"
                     /calculated_mol_wt=74561
     Region          43..154
                     /region_name="SCAN"
                     /note="leucine rich region; smart00431"
                     /db_xref="CDD:128708"
     Region          237..297
                     /region_name="KRAB"
                     /note="krueppel associated box; smart00349"
                     /db_xref="CDD:214630"
     Region          397..>644
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          399..419
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(404,406,408,410..411,414..415,418,432,434,438..439,
                     442..443,446,488,490,492,494..495,498..499,502)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          427..447
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          483..503
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          511..531
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          539..559
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          567..587
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(572,574,576,578..579,582..583,586,600,602,606..607,
                     610..611,614,628,630,632,634..635,638..639,642)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          595..615
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          623..643
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..648
                     /gene="ZNF202"
                     /gene_synonym="ZKSCAN10; ZSCAN42"
                     /coded_by="XM_054369892.1:446..2392"
                     /db_xref="GeneID:7753"
                     /db_xref="HGNC:HGNC:12994"
                     /db_xref="MIM:603430"
ORIGIN      
        1 matavepedq dlweeegilm vkleddftcr pesvlqrddp vletshqnfr rfryqeaasp
       61 realirlrel chqwlrperr tkeqilellv leqfltvlpg elqswvrgqr pesgeeavtl
      121 veglqkqprr prrwvtvhvh gqevlseetv hlgaepespn elqdpvqsst peqspeettq
      181 spdlgapaeq rphqeeelqt lqesevpvpe dpdlpaerss gdsemvallt alsqglvtfk
      241 dvavcfsqdq wsdldptqke fygeyvleed cgivvslsfp iprpdeisqv reeepwvpdi
      301 qepqetqepe ilsftytgdr skdeeecleq edlsledihr pvlgepeihq tpdweivfed
      361 npgrlnerrf gtnisqvnsf vnlrettpvh pllgrhhdcs vcgksftcns hlvrhlrtht
      421 gekpykcmec gksytrsshl arhqkvhkmn apykyplnrk nleetspvtq aertpsvekp
      481 yrcddcgkhf rwtsdlvrhq rthtgekpff cticgksfsq ksvltthqri hlggkpylcg
      541 ecgedfsehr rylahrktha aeelylcsec grcfthsaaf akhlrghasv rpcrcnecgk
      601 sfsrrdhlvr hqrthtgekp ftcptcgksf srgyhlirhq rthsekts
//
LOCUS       XP_054225868             648 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 202 isoform X1 [Homo sapiens].
ACCESSION   XP_054225868
VERSION     XP_054225868.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369893.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..648
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..648
                     /product="zinc finger protein 202 isoform X1"
                     /calculated_mol_wt=74561
     Region          43..154
                     /region_name="SCAN"
                     /note="leucine rich region; smart00431"
                     /db_xref="CDD:128708"
     Region          237..297
                     /region_name="KRAB"
                     /note="krueppel associated box; smart00349"
                     /db_xref="CDD:214630"
     Region          397..>644
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          399..419
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(404,406,408,410..411,414..415,418,432,434,438..439,
                     442..443,446,488,490,492,494..495,498..499,502)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          427..447
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          483..503
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          511..531
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          539..559
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          567..587
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(572,574,576,578..579,582..583,586,600,602,606..607,
                     610..611,614,628,630,632,634..635,638..639,642)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          595..615
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          623..643
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..648
                     /gene="ZNF202"
                     /gene_synonym="ZKSCAN10; ZSCAN42"
                     /coded_by="XM_054369893.1:330..2276"
                     /db_xref="GeneID:7753"
                     /db_xref="HGNC:HGNC:12994"
                     /db_xref="MIM:603430"
ORIGIN      
        1 matavepedq dlweeegilm vkleddftcr pesvlqrddp vletshqnfr rfryqeaasp
       61 realirlrel chqwlrperr tkeqilellv leqfltvlpg elqswvrgqr pesgeeavtl
      121 veglqkqprr prrwvtvhvh gqevlseetv hlgaepespn elqdpvqsst peqspeettq
      181 spdlgapaeq rphqeeelqt lqesevpvpe dpdlpaerss gdsemvallt alsqglvtfk
      241 dvavcfsqdq wsdldptqke fygeyvleed cgivvslsfp iprpdeisqv reeepwvpdi
      301 qepqetqepe ilsftytgdr skdeeecleq edlsledihr pvlgepeihq tpdweivfed
      361 npgrlnerrf gtnisqvnsf vnlrettpvh pllgrhhdcs vcgksftcns hlvrhlrtht
      421 gekpykcmec gksytrsshl arhqkvhkmn apykyplnrk nleetspvtq aertpsvekp
      481 yrcddcgkhf rwtsdlvrhq rthtgekpff cticgksfsq ksvltthqri hlggkpylcg
      541 ecgedfsehr rylahrktha aeelylcsec grcfthsaaf akhlrghasv rpcrcnecgk
      601 sfsrrdhlvr hqrthtgekp ftcptcgksf srgyhlirhq rthsekts
//
LOCUS       XP_054225869             648 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 202 isoform X1 [Homo sapiens].
ACCESSION   XP_054225869
VERSION     XP_054225869.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369894.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..648
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..648
                     /product="zinc finger protein 202 isoform X1"
                     /calculated_mol_wt=74561
     Region          43..154
                     /region_name="SCAN"
                     /note="leucine rich region; smart00431"
                     /db_xref="CDD:128708"
     Region          237..297
                     /region_name="KRAB"
                     /note="krueppel associated box; smart00349"
                     /db_xref="CDD:214630"
     Region          397..>644
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          399..419
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(404,406,408,410..411,414..415,418,432,434,438..439,
                     442..443,446,488,490,492,494..495,498..499,502)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          427..447
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          483..503
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          511..531
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          539..559
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          567..587
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(572,574,576,578..579,582..583,586,600,602,606..607,
                     610..611,614,628,630,632,634..635,638..639,642)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          595..615
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          623..643
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..648
                     /gene="ZNF202"
                     /gene_synonym="ZKSCAN10; ZSCAN42"
                     /coded_by="XM_054369894.1:1259..3205"
                     /db_xref="GeneID:7753"
                     /db_xref="HGNC:HGNC:12994"
                     /db_xref="MIM:603430"
ORIGIN      
        1 matavepedq dlweeegilm vkleddftcr pesvlqrddp vletshqnfr rfryqeaasp
       61 realirlrel chqwlrperr tkeqilellv leqfltvlpg elqswvrgqr pesgeeavtl
      121 veglqkqprr prrwvtvhvh gqevlseetv hlgaepespn elqdpvqsst peqspeettq
      181 spdlgapaeq rphqeeelqt lqesevpvpe dpdlpaerss gdsemvallt alsqglvtfk
      241 dvavcfsqdq wsdldptqke fygeyvleed cgivvslsfp iprpdeisqv reeepwvpdi
      301 qepqetqepe ilsftytgdr skdeeecleq edlsledihr pvlgepeihq tpdweivfed
      361 npgrlnerrf gtnisqvnsf vnlrettpvh pllgrhhdcs vcgksftcns hlvrhlrtht
      421 gekpykcmec gksytrsshl arhqkvhkmn apykyplnrk nleetspvtq aertpsvekp
      481 yrcddcgkhf rwtsdlvrhq rthtgekpff cticgksfsq ksvltthqri hlggkpylcg
      541 ecgedfsehr rylahrktha aeelylcsec grcfthsaaf akhlrghasv rpcrcnecgk
      601 sfsrrdhlvr hqrthtgekp ftcptcgksf srgyhlirhq rthsekts
//
LOCUS       XP_054225870             648 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 202 isoform X1 [Homo sapiens].
ACCESSION   XP_054225870
VERSION     XP_054225870.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369895.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..648
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..648
                     /product="zinc finger protein 202 isoform X1"
                     /calculated_mol_wt=74561
     Region          43..154
                     /region_name="SCAN"
                     /note="leucine rich region; smart00431"
                     /db_xref="CDD:128708"
     Region          237..297
                     /region_name="KRAB"
                     /note="krueppel associated box; smart00349"
                     /db_xref="CDD:214630"
     Region          397..>644
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          399..419
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(404,406,408,410..411,414..415,418,432,434,438..439,
                     442..443,446,488,490,492,494..495,498..499,502)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          427..447
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          483..503
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          511..531
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          539..559
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          567..587
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(572,574,576,578..579,582..583,586,600,602,606..607,
                     610..611,614,628,630,632,634..635,638..639,642)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          595..615
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          623..643
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..648
                     /gene="ZNF202"
                     /gene_synonym="ZKSCAN10; ZSCAN42"
                     /coded_by="XM_054369895.1:557..2503"
                     /db_xref="GeneID:7753"
                     /db_xref="HGNC:HGNC:12994"
                     /db_xref="MIM:603430"
ORIGIN      
        1 matavepedq dlweeegilm vkleddftcr pesvlqrddp vletshqnfr rfryqeaasp
       61 realirlrel chqwlrperr tkeqilellv leqfltvlpg elqswvrgqr pesgeeavtl
      121 veglqkqprr prrwvtvhvh gqevlseetv hlgaepespn elqdpvqsst peqspeettq
      181 spdlgapaeq rphqeeelqt lqesevpvpe dpdlpaerss gdsemvallt alsqglvtfk
      241 dvavcfsqdq wsdldptqke fygeyvleed cgivvslsfp iprpdeisqv reeepwvpdi
      301 qepqetqepe ilsftytgdr skdeeecleq edlsledihr pvlgepeihq tpdweivfed
      361 npgrlnerrf gtnisqvnsf vnlrettpvh pllgrhhdcs vcgksftcns hlvrhlrtht
      421 gekpykcmec gksytrsshl arhqkvhkmn apykyplnrk nleetspvtq aertpsvekp
      481 yrcddcgkhf rwtsdlvrhq rthtgekpff cticgksfsq ksvltthqri hlggkpylcg
      541 ecgedfsehr rylahrktha aeelylcsec grcfthsaaf akhlrghasv rpcrcnecgk
      601 sfsrrdhlvr hqrthtgekp ftcptcgksf srgyhlirhq rthsekts
//
LOCUS       XP_054225871             648 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 202 isoform X1 [Homo sapiens].
ACCESSION   XP_054225871
VERSION     XP_054225871.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369896.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..648
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..648
                     /product="zinc finger protein 202 isoform X1"
                     /calculated_mol_wt=74561
     Region          43..154
                     /region_name="SCAN"
                     /note="leucine rich region; smart00431"
                     /db_xref="CDD:128708"
     Region          237..297
                     /region_name="KRAB"
                     /note="krueppel associated box; smart00349"
                     /db_xref="CDD:214630"
     Region          397..>644
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          399..419
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(404,406,408,410..411,414..415,418,432,434,438..439,
                     442..443,446,488,490,492,494..495,498..499,502)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          427..447
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          483..503
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          511..531
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          539..559
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          567..587
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(572,574,576,578..579,582..583,586,600,602,606..607,
                     610..611,614,628,630,632,634..635,638..639,642)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          595..615
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          623..643
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..648
                     /gene="ZNF202"
                     /gene_synonym="ZKSCAN10; ZSCAN42"
                     /coded_by="XM_054369896.1:470..2416"
                     /db_xref="GeneID:7753"
                     /db_xref="HGNC:HGNC:12994"
                     /db_xref="MIM:603430"
ORIGIN      
        1 matavepedq dlweeegilm vkleddftcr pesvlqrddp vletshqnfr rfryqeaasp
       61 realirlrel chqwlrperr tkeqilellv leqfltvlpg elqswvrgqr pesgeeavtl
      121 veglqkqprr prrwvtvhvh gqevlseetv hlgaepespn elqdpvqsst peqspeettq
      181 spdlgapaeq rphqeeelqt lqesevpvpe dpdlpaerss gdsemvallt alsqglvtfk
      241 dvavcfsqdq wsdldptqke fygeyvleed cgivvslsfp iprpdeisqv reeepwvpdi
      301 qepqetqepe ilsftytgdr skdeeecleq edlsledihr pvlgepeihq tpdweivfed
      361 npgrlnerrf gtnisqvnsf vnlrettpvh pllgrhhdcs vcgksftcns hlvrhlrtht
      421 gekpykcmec gksytrsshl arhqkvhkmn apykyplnrk nleetspvtq aertpsvekp
      481 yrcddcgkhf rwtsdlvrhq rthtgekpff cticgksfsq ksvltthqri hlggkpylcg
      541 ecgedfsehr rylahrktha aeelylcsec grcfthsaaf akhlrghasv rpcrcnecgk
      601 sfsrrdhlvr hqrthtgekp ftcptcgksf srgyhlirhq rthsekts
//
LOCUS       XP_054225872             648 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 202 isoform X1 [Homo sapiens].
ACCESSION   XP_054225872
VERSION     XP_054225872.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369897.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..648
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..648
                     /product="zinc finger protein 202 isoform X1"
                     /calculated_mol_wt=74561
     Region          43..154
                     /region_name="SCAN"
                     /note="leucine rich region; smart00431"
                     /db_xref="CDD:128708"
     Region          237..297
                     /region_name="KRAB"
                     /note="krueppel associated box; smart00349"
                     /db_xref="CDD:214630"
     Region          397..>644
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          399..419
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(404,406,408,410..411,414..415,418,432,434,438..439,
                     442..443,446,488,490,492,494..495,498..499,502)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          427..447
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          483..503
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          511..531
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          539..559
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          567..587
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(572,574,576,578..579,582..583,586,600,602,606..607,
                     610..611,614,628,630,632,634..635,638..639,642)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          595..615
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          623..643
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..648
                     /gene="ZNF202"
                     /gene_synonym="ZKSCAN10; ZSCAN42"
                     /coded_by="XM_054369897.1:903..2849"
                     /db_xref="GeneID:7753"
                     /db_xref="HGNC:HGNC:12994"
                     /db_xref="MIM:603430"
ORIGIN      
        1 matavepedq dlweeegilm vkleddftcr pesvlqrddp vletshqnfr rfryqeaasp
       61 realirlrel chqwlrperr tkeqilellv leqfltvlpg elqswvrgqr pesgeeavtl
      121 veglqkqprr prrwvtvhvh gqevlseetv hlgaepespn elqdpvqsst peqspeettq
      181 spdlgapaeq rphqeeelqt lqesevpvpe dpdlpaerss gdsemvallt alsqglvtfk
      241 dvavcfsqdq wsdldptqke fygeyvleed cgivvslsfp iprpdeisqv reeepwvpdi
      301 qepqetqepe ilsftytgdr skdeeecleq edlsledihr pvlgepeihq tpdweivfed
      361 npgrlnerrf gtnisqvnsf vnlrettpvh pllgrhhdcs vcgksftcns hlvrhlrtht
      421 gekpykcmec gksytrsshl arhqkvhkmn apykyplnrk nleetspvtq aertpsvekp
      481 yrcddcgkhf rwtsdlvrhq rthtgekpff cticgksfsq ksvltthqri hlggkpylcg
      541 ecgedfsehr rylahrktha aeelylcsec grcfthsaaf akhlrghasv rpcrcnecgk
      601 sfsrrdhlvr hqrthtgekp ftcptcgksf srgyhlirhq rthsekts
//
LOCUS       XP_054225873             648 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 202 isoform X1 [Homo sapiens].
ACCESSION   XP_054225873
VERSION     XP_054225873.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369898.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..648
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..648
                     /product="zinc finger protein 202 isoform X1"
                     /calculated_mol_wt=74561
     Region          43..154
                     /region_name="SCAN"
                     /note="leucine rich region; smart00431"
                     /db_xref="CDD:128708"
     Region          237..297
                     /region_name="KRAB"
                     /note="krueppel associated box; smart00349"
                     /db_xref="CDD:214630"
     Region          397..>644
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          399..419
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(404,406,408,410..411,414..415,418,432,434,438..439,
                     442..443,446,488,490,492,494..495,498..499,502)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          427..447
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          483..503
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          511..531
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          539..559
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          567..587
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(572,574,576,578..579,582..583,586,600,602,606..607,
                     610..611,614,628,630,632,634..635,638..639,642)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          595..615
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          623..643
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..648
                     /gene="ZNF202"
                     /gene_synonym="ZKSCAN10; ZSCAN42"
                     /coded_by="XM_054369898.1:581..2527"
                     /db_xref="GeneID:7753"
                     /db_xref="HGNC:HGNC:12994"
                     /db_xref="MIM:603430"
ORIGIN      
        1 matavepedq dlweeegilm vkleddftcr pesvlqrddp vletshqnfr rfryqeaasp
       61 realirlrel chqwlrperr tkeqilellv leqfltvlpg elqswvrgqr pesgeeavtl
      121 veglqkqprr prrwvtvhvh gqevlseetv hlgaepespn elqdpvqsst peqspeettq
      181 spdlgapaeq rphqeeelqt lqesevpvpe dpdlpaerss gdsemvallt alsqglvtfk
      241 dvavcfsqdq wsdldptqke fygeyvleed cgivvslsfp iprpdeisqv reeepwvpdi
      301 qepqetqepe ilsftytgdr skdeeecleq edlsledihr pvlgepeihq tpdweivfed
      361 npgrlnerrf gtnisqvnsf vnlrettpvh pllgrhhdcs vcgksftcns hlvrhlrtht
      421 gekpykcmec gksytrsshl arhqkvhkmn apykyplnrk nleetspvtq aertpsvekp
      481 yrcddcgkhf rwtsdlvrhq rthtgekpff cticgksfsq ksvltthqri hlggkpylcg
      541 ecgedfsehr rylahrktha aeelylcsec grcfthsaaf akhlrghasv rpcrcnecgk
      601 sfsrrdhlvr hqrthtgekp ftcptcgksf srgyhlirhq rthsekts
//
LOCUS       XP_054225874             606 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 214 isoform X1 [Homo sapiens].
ACCESSION   XP_054225874
VERSION     XP_054225874.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369899.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..606
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..606
                     /product="zinc finger protein 214 isoform X1"
                     /calculated_mol_wt=70878
     Region          3..42
                     /region_name="KRAB"
                     /note="KRAB box; pfam01352"
                     /db_xref="CDD:460171"
     Region          235..576
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          277..297
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          305..325
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          334..352
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          360..380
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(365,367,369,371..372,375..376,379,393,395,399..400,
                     403..404,407,421,423,425,427..428,431..432,435)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          388..408
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          416..436
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          444..464
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          472..492
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(477,479,481,483..484,487..488,491,505,507,511..512,
                     515..516,519,533,535,537,539..540,543..544,547)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          500..520
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          528..548
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          556..576
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          584..603
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..606
                     /gene="ZNF214"
                     /gene_synonym="BAZ-1; BAZ1"
                     /coded_by="XM_054369899.1:89..1909"
                     /db_xref="GeneID:7761"
                     /db_xref="HGNC:HGNC:13006"
                     /db_xref="MIM:605015"
ORIGIN      
        1 mavtfedvti iftweewkfl dssqkrlyre vmwenytnvm svenwnesyk sqeekfryle
       61 yenfscwqgw wnagaqmyen qnygetvqgt dskdltqqdr sqcqewlils tqvpgygnye
      121 ltfeskshrn lkyknfmpwq sletkttqdy greiymsgsh gfqggryrlg isrknlsmek
      181 eqklivqhsy ipveealpqy vgvicqedll rdsmeekycg cnkckgiyyw nsrcvfhkrn
      241 qpgenlcqcs irkacfsqrs dlyrhprnhi gkklygcdev dgnfhqssgv hfhqrvhige
      301 vpyscnacgk sfsqisslhn hqrvhteekf ykiecdkdls rnsllhihqr lhigekpfkc
      361 nqcgksfnrs svlhvhqrvh tgekpykcde cgkgfsqssn lrihqlvhtg eksykcedcg
      421 kgftqrsnlq ihqrvhtgek pykcddcgkd fshssdlrih qrvhtgekpy tcpecgkgfs
      481 kssklhthqr vhtgekpykc eecgkgfsqr shllihqrvh tgekpykchd cgkgfshssn
      541 lhihqrvhtg ekpyqcakcg kgfshssalr ihqrvhagek pykcreyykg fdhnshlhnn
      601 hrrgnl
//
LOCUS       XP_054225875             592 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 214 isoform X2 [Homo sapiens].
ACCESSION   XP_054225875
VERSION     XP_054225875.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369900.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..592
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..592
                     /product="zinc finger protein 214 isoform X2"
                     /calculated_mol_wt=68646
     Region          221..562
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          263..283
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          291..311
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          320..338
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          346..366
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          374..394
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          402..422
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          430..450
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          458..478
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(463,465,467,469..470,473..474,477,491,493,497..498,
                     501..502,505,519,521,523,525..526,529..530,533)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          486..506
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          514..534
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          542..562
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          570..589
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..592
                     /gene="ZNF214"
                     /gene_synonym="BAZ-1; BAZ1"
                     /coded_by="XM_054369900.1:122..1900"
                     /db_xref="GeneID:7761"
                     /db_xref="HGNC:HGNC:13006"
                     /db_xref="MIM:605015"
ORIGIN      
        1 mggveipgff skktlqgghv gelhkchvkn wnesyksqee kfryleyenf scwqgwwnag
       61 aqmyenqnyg etvqgtdskd ltqqdrsqcq ewlilstqvp gygnyeltfe skshrnlkyk
      121 nfmpwqslet kttqdygrei ymsgshgfqg gryrlgisrk nlsmekeqkl ivqhsyipve
      181 ealpqyvgvi cqedllrdsm eekycgcnkc kgiyywnsrc vfhkrnqpge nlcqcsirka
      241 cfsqrsdlyr hprnhigkkl ygcdevdgnf hqssgvhfhq rvhigevpys cnacgksfsq
      301 isslhnhqrv hteekfykie cdkdlsrnsl lhihqrlhig ekpfkcnqcg ksfnrssvlh
      361 vhqrvhtgek pykcdecgkg fsqssnlrih qlvhtgeksy kcedcgkgft qrsnlqihqr
      421 vhtgekpykc ddcgkdfshs sdlrihqrvh tgekpytcpe cgkgfskssk lhthqrvhtg
      481 ekpykceecg kgfsqrshll ihqrvhtgek pykchdcgkg fshssnlhih qrvhtgekpy
      541 qcakcgkgfs hssalrihqr vhagekpykc reyykgfdhn shlhnnhrrg nl
//
LOCUS       XP_054225876             592 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 214 isoform X2 [Homo sapiens].
ACCESSION   XP_054225876
VERSION     XP_054225876.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369901.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..592
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..592
                     /product="zinc finger protein 214 isoform X2"
                     /calculated_mol_wt=68646
     Region          221..562
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          263..283
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          291..311
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          320..338
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          346..366
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          374..394
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          402..422
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          430..450
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          458..478
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(463,465,467,469..470,473..474,477,491,493,497..498,
                     501..502,505,519,521,523,525..526,529..530,533)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          486..506
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          514..534
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          542..562
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          570..589
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..592
                     /gene="ZNF214"
                     /gene_synonym="BAZ-1; BAZ1"
                     /coded_by="XM_054369901.1:329..2107"
                     /db_xref="GeneID:7761"
                     /db_xref="HGNC:HGNC:13006"
                     /db_xref="MIM:605015"
ORIGIN      
        1 mggveipgff skktlqgghv gelhkchvkn wnesyksqee kfryleyenf scwqgwwnag
       61 aqmyenqnyg etvqgtdskd ltqqdrsqcq ewlilstqvp gygnyeltfe skshrnlkyk
      121 nfmpwqslet kttqdygrei ymsgshgfqg gryrlgisrk nlsmekeqkl ivqhsyipve
      181 ealpqyvgvi cqedllrdsm eekycgcnkc kgiyywnsrc vfhkrnqpge nlcqcsirka
      241 cfsqrsdlyr hprnhigkkl ygcdevdgnf hqssgvhfhq rvhigevpys cnacgksfsq
      301 isslhnhqrv hteekfykie cdkdlsrnsl lhihqrlhig ekpfkcnqcg ksfnrssvlh
      361 vhqrvhtgek pykcdecgkg fsqssnlrih qlvhtgeksy kcedcgkgft qrsnlqihqr
      421 vhtgekpykc ddcgkdfshs sdlrihqrvh tgekpytcpe cgkgfskssk lhthqrvhtg
      481 ekpykceecg kgfsqrshll ihqrvhtgek pykchdcgkg fshssnlhih qrvhtgekpy
      541 qcakcgkgfs hssalrihqr vhagekpykc reyykgfdhn shlhnnhrrg nl
//
LOCUS       XP_054225877             592 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 214 isoform X2 [Homo sapiens].
ACCESSION   XP_054225877
VERSION     XP_054225877.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369902.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..592
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..592
                     /product="zinc finger protein 214 isoform X2"
                     /calculated_mol_wt=68646
     Region          221..562
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          263..283
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          291..311
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          320..338
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          346..366
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          374..394
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          402..422
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          430..450
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          458..478
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(463,465,467,469..470,473..474,477,491,493,497..498,
                     501..502,505,519,521,523,525..526,529..530,533)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          486..506
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          514..534
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          542..562
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          570..589
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..592
                     /gene="ZNF214"
                     /gene_synonym="BAZ-1; BAZ1"
                     /coded_by="XM_054369902.1:108..1886"
                     /db_xref="GeneID:7761"
                     /db_xref="HGNC:HGNC:13006"
                     /db_xref="MIM:605015"
ORIGIN      
        1 mggveipgff skktlqgghv gelhkchvkn wnesyksqee kfryleyenf scwqgwwnag
       61 aqmyenqnyg etvqgtdskd ltqqdrsqcq ewlilstqvp gygnyeltfe skshrnlkyk
      121 nfmpwqslet kttqdygrei ymsgshgfqg gryrlgisrk nlsmekeqkl ivqhsyipve
      181 ealpqyvgvi cqedllrdsm eekycgcnkc kgiyywnsrc vfhkrnqpge nlcqcsirka
      241 cfsqrsdlyr hprnhigkkl ygcdevdgnf hqssgvhfhq rvhigevpys cnacgksfsq
      301 isslhnhqrv hteekfykie cdkdlsrnsl lhihqrlhig ekpfkcnqcg ksfnrssvlh
      361 vhqrvhtgek pykcdecgkg fsqssnlrih qlvhtgeksy kcedcgkgft qrsnlqihqr
      421 vhtgekpykc ddcgkdfshs sdlrihqrvh tgekpytcpe cgkgfskssk lhthqrvhtg
      481 ekpykceecg kgfsqrshll ihqrvhtgek pykchdcgkg fshssnlhih qrvhtgekpy
      541 qcakcgkgfs hssalrihqr vhagekpykc reyykgfdhn shlhnnhrrg nl
//
LOCUS       XP_054225878             517 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 215 isoform X1 [Homo sapiens].
ACCESSION   XP_054225878
VERSION     XP_054225878.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369903.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..517
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..517
                     /product="zinc finger protein 215 isoform X1"
                     /calculated_mol_wt=59918
     Region          44..132
                     /region_name="SCAN"
                     /note="SCAN domain; pfam02023"
                     /db_xref="CDD:460417"
     Region          164..226
                     /region_name="KRAB"
                     /note="krueppel associated box; smart00349"
                     /db_xref="CDD:214630"
     Region          379..401
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          381..401
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(386,388,390,392..393,396..397,400,469,471,475..476,
                     479..480,483,497,499,501,503..504,507..508,511)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          393..418
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          409..484
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          412..429
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          436..>517
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          476..501
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          492..512
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..517
                     /gene="ZNF215"
                     /gene_synonym="BAZ-2; BAZ2; ZKSCAN11; ZSCAN43"
                     /coded_by="XM_054369903.1:762..2315"
                     /db_xref="GeneID:7762"
                     /db_xref="HGNC:HGNC:13007"
                     /db_xref="MIM:605016"
ORIGIN      
        1 mqplsklmai skprnlslre qrevlradms wqqetnpvve thdseasrqk frhfqylkvs
       61 gphealsqlw elclqwlrpe ihtkkqiiel lvleqflail peevrtwvnl qhpnnskdmv
      121 tliedvieml ededmpckds alqmgsikek mkagsrtgkp qepvtfkdvv vefskeewgq
      181 ldsavknlyr nvmlenfrnl nslrkahlls kpfeslkles kkkrwimeke iprktifdmk
      241 sisgeesshg vimtrltesg hpssdawkge nwlyrnqkkw dinlpqeafi petiyteeed
      301 fecsenkksf dinsvssica iqlgipsrkg spkcdkfkty fkfnldsvgk qhseyeygnd
      361 lslstdirhq kshttmnsye cyqcgkafcr ssslirhqii htgekpykcs ecgrffnrrt
      421 nltkhqklha eakactsnkc gkafskseds nnptlhfgnn fyqcvncgks fnrssslirh
      481 qmihtgekpf kckecskafn rssnlvkhqk lhtrdks
//
LOCUS       XP_054225879             517 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 215 isoform X1 [Homo sapiens].
ACCESSION   XP_054225879
VERSION     XP_054225879.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369904.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..517
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..517
                     /product="zinc finger protein 215 isoform X1"
                     /calculated_mol_wt=59918
     Region          44..132
                     /region_name="SCAN"
                     /note="SCAN domain; pfam02023"
                     /db_xref="CDD:460417"
     Region          164..226
                     /region_name="KRAB"
                     /note="krueppel associated box; smart00349"
                     /db_xref="CDD:214630"
     Region          379..401
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          381..401
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(386,388,390,392..393,396..397,400,469,471,475..476,
                     479..480,483,497,499,501,503..504,507..508,511)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          393..418
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          409..484
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          412..429
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          436..>517
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          476..501
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          492..512
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..517
                     /gene="ZNF215"
                     /gene_synonym="BAZ-2; BAZ2; ZKSCAN11; ZSCAN43"
                     /coded_by="XM_054369904.1:4874..6427"
                     /db_xref="GeneID:7762"
                     /db_xref="HGNC:HGNC:13007"
                     /db_xref="MIM:605016"
ORIGIN      
        1 mqplsklmai skprnlslre qrevlradms wqqetnpvve thdseasrqk frhfqylkvs
       61 gphealsqlw elclqwlrpe ihtkkqiiel lvleqflail peevrtwvnl qhpnnskdmv
      121 tliedvieml ededmpckds alqmgsikek mkagsrtgkp qepvtfkdvv vefskeewgq
      181 ldsavknlyr nvmlenfrnl nslrkahlls kpfeslkles kkkrwimeke iprktifdmk
      241 sisgeesshg vimtrltesg hpssdawkge nwlyrnqkkw dinlpqeafi petiyteeed
      301 fecsenkksf dinsvssica iqlgipsrkg spkcdkfkty fkfnldsvgk qhseyeygnd
      361 lslstdirhq kshttmnsye cyqcgkafcr ssslirhqii htgekpykcs ecgrffnrrt
      421 nltkhqklha eakactsnkc gkafskseds nnptlhfgnn fyqcvncgks fnrssslirh
      481 qmihtgekpf kckecskafn rssnlvkhqk lhtrdks
//
LOCUS       XP_054225880             517 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 215 isoform X1 [Homo sapiens].
ACCESSION   XP_054225880
VERSION     XP_054225880.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369905.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..517
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..517
                     /product="zinc finger protein 215 isoform X1"
                     /calculated_mol_wt=59918
     Region          44..132
                     /region_name="SCAN"
                     /note="SCAN domain; pfam02023"
                     /db_xref="CDD:460417"
     Region          164..226
                     /region_name="KRAB"
                     /note="krueppel associated box; smart00349"
                     /db_xref="CDD:214630"
     Region          379..401
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          381..401
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(386,388,390,392..393,396..397,400,469,471,475..476,
                     479..480,483,497,499,501,503..504,507..508,511)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          393..418
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          409..484
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          412..429
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          436..>517
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          476..501
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          492..512
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..517
                     /gene="ZNF215"
                     /gene_synonym="BAZ-2; BAZ2; ZKSCAN11; ZSCAN43"
                     /coded_by="XM_054369905.1:444..1997"
                     /db_xref="GeneID:7762"
                     /db_xref="HGNC:HGNC:13007"
                     /db_xref="MIM:605016"
ORIGIN      
        1 mqplsklmai skprnlslre qrevlradms wqqetnpvve thdseasrqk frhfqylkvs
       61 gphealsqlw elclqwlrpe ihtkkqiiel lvleqflail peevrtwvnl qhpnnskdmv
      121 tliedvieml ededmpckds alqmgsikek mkagsrtgkp qepvtfkdvv vefskeewgq
      181 ldsavknlyr nvmlenfrnl nslrkahlls kpfeslkles kkkrwimeke iprktifdmk
      241 sisgeesshg vimtrltesg hpssdawkge nwlyrnqkkw dinlpqeafi petiyteeed
      301 fecsenkksf dinsvssica iqlgipsrkg spkcdkfkty fkfnldsvgk qhseyeygnd
      361 lslstdirhq kshttmnsye cyqcgkafcr ssslirhqii htgekpykcs ecgrffnrrt
      421 nltkhqklha eakactsnkc gkafskseds nnptlhfgnn fyqcvncgks fnrssslirh
      481 qmihtgekpf kckecskafn rssnlvkhqk lhtrdks
//
LOCUS       XP_054225881             517 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 215 isoform X1 [Homo sapiens].
ACCESSION   XP_054225881
VERSION     XP_054225881.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369906.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..517
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..517
                     /product="zinc finger protein 215 isoform X1"
                     /calculated_mol_wt=59918
     Region          44..132
                     /region_name="SCAN"
                     /note="SCAN domain; pfam02023"
                     /db_xref="CDD:460417"
     Region          164..226
                     /region_name="KRAB"
                     /note="krueppel associated box; smart00349"
                     /db_xref="CDD:214630"
     Region          379..401
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          381..401
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(386,388,390,392..393,396..397,400,469,471,475..476,
                     479..480,483,497,499,501,503..504,507..508,511)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          393..418
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          409..484
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          412..429
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          436..>517
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          476..501
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          492..512
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..517
                     /gene="ZNF215"
                     /gene_synonym="BAZ-2; BAZ2; ZKSCAN11; ZSCAN43"
                     /coded_by="XM_054369906.1:5050..6603"
                     /db_xref="GeneID:7762"
                     /db_xref="HGNC:HGNC:13007"
                     /db_xref="MIM:605016"
ORIGIN      
        1 mqplsklmai skprnlslre qrevlradms wqqetnpvve thdseasrqk frhfqylkvs
       61 gphealsqlw elclqwlrpe ihtkkqiiel lvleqflail peevrtwvnl qhpnnskdmv
      121 tliedvieml ededmpckds alqmgsikek mkagsrtgkp qepvtfkdvv vefskeewgq
      181 ldsavknlyr nvmlenfrnl nslrkahlls kpfeslkles kkkrwimeke iprktifdmk
      241 sisgeesshg vimtrltesg hpssdawkge nwlyrnqkkw dinlpqeafi petiyteeed
      301 fecsenkksf dinsvssica iqlgipsrkg spkcdkfkty fkfnldsvgk qhseyeygnd
      361 lslstdirhq kshttmnsye cyqcgkafcr ssslirhqii htgekpykcs ecgrffnrrt
      421 nltkhqklha eakactsnkc gkafskseds nnptlhfgnn fyqcvncgks fnrssslirh
      481 qmihtgekpf kckecskafn rssnlvkhqk lhtrdks
//
LOCUS       XP_054225882             517 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 215 isoform X1 [Homo sapiens].
ACCESSION   XP_054225882
VERSION     XP_054225882.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369907.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..517
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..517
                     /product="zinc finger protein 215 isoform X1"
                     /calculated_mol_wt=59918
     Region          44..132
                     /region_name="SCAN"
                     /note="SCAN domain; pfam02023"
                     /db_xref="CDD:460417"
     Region          164..226
                     /region_name="KRAB"
                     /note="krueppel associated box; smart00349"
                     /db_xref="CDD:214630"
     Region          379..401
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          381..401
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(386,388,390,392..393,396..397,400,469,471,475..476,
                     479..480,483,497,499,501,503..504,507..508,511)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          393..418
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          409..484
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          412..429
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          436..>517
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          476..501
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          492..512
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..517
                     /gene="ZNF215"
                     /gene_synonym="BAZ-2; BAZ2; ZKSCAN11; ZSCAN43"
                     /coded_by="XM_054369907.1:4698..6251"
                     /db_xref="GeneID:7762"
                     /db_xref="HGNC:HGNC:13007"
                     /db_xref="MIM:605016"
ORIGIN      
        1 mqplsklmai skprnlslre qrevlradms wqqetnpvve thdseasrqk frhfqylkvs
       61 gphealsqlw elclqwlrpe ihtkkqiiel lvleqflail peevrtwvnl qhpnnskdmv
      121 tliedvieml ededmpckds alqmgsikek mkagsrtgkp qepvtfkdvv vefskeewgq
      181 ldsavknlyr nvmlenfrnl nslrkahlls kpfeslkles kkkrwimeke iprktifdmk
      241 sisgeesshg vimtrltesg hpssdawkge nwlyrnqkkw dinlpqeafi petiyteeed
      301 fecsenkksf dinsvssica iqlgipsrkg spkcdkfkty fkfnldsvgk qhseyeygnd
      361 lslstdirhq kshttmnsye cyqcgkafcr ssslirhqii htgekpykcs ecgrffnrrt
      421 nltkhqklha eakactsnkc gkafskseds nnptlhfgnn fyqcvncgks fnrssslirh
      481 qmihtgekpf kckecskafn rssnlvkhqk lhtrdks
//
LOCUS       XP_054225883             272 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 215 isoform X2 [Homo sapiens].
ACCESSION   XP_054225883
VERSION     XP_054225883.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369908.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..272
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..272
                     /product="zinc finger protein 215 isoform X2"
                     /calculated_mol_wt=31586
     Region          44..132
                     /region_name="SCAN"
                     /note="SCAN domain; pfam02023"
                     /db_xref="CDD:460417"
     Region          164..226
                     /region_name="KRAB"
                     /note="krueppel associated box; smart00349"
                     /db_xref="CDD:214630"
     CDS             1..272
                     /gene="ZNF215"
                     /gene_synonym="BAZ-2; BAZ2; ZKSCAN11; ZSCAN43"
                     /coded_by="XM_054369908.1:586..1404"
                     /db_xref="GeneID:7762"
                     /db_xref="HGNC:HGNC:13007"
                     /db_xref="MIM:605016"
ORIGIN      
        1 mqplsklmai skprnlslre qrevlradms wqqetnpvve thdseasrqk frhfqylkvs
       61 gphealsqlw elclqwlrpe ihtkkqiiel lvleqflail peevrtwvnl qhpnnskdmv
      121 tliedvieml ededmpckds alqmgsikek mkagsrtgkp qepvtfkdvv vefskeewgq
      181 ldsavknlyr nvmlenfrnl nslrkahlls kpfeslkles kkkrwimeke iprktifdmk
      241 sisgeesshg vimtrltesg hpssdawkgr th
//
LOCUS       XP_054225884             272 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 215 isoform X2 [Homo sapiens].
ACCESSION   XP_054225884
VERSION     XP_054225884.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369909.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..272
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..272
                     /product="zinc finger protein 215 isoform X2"
                     /calculated_mol_wt=31586
     Region          44..132
                     /region_name="SCAN"
                     /note="SCAN domain; pfam02023"
                     /db_xref="CDD:460417"
     Region          164..226
                     /region_name="KRAB"
                     /note="krueppel associated box; smart00349"
                     /db_xref="CDD:214630"
     CDS             1..272
                     /gene="ZNF215"
                     /gene_synonym="BAZ-2; BAZ2; ZKSCAN11; ZSCAN43"
                     /coded_by="XM_054369909.1:629..1447"
                     /db_xref="GeneID:7762"
                     /db_xref="HGNC:HGNC:13007"
                     /db_xref="MIM:605016"
ORIGIN      
        1 mqplsklmai skprnlslre qrevlradms wqqetnpvve thdseasrqk frhfqylkvs
       61 gphealsqlw elclqwlrpe ihtkkqiiel lvleqflail peevrtwvnl qhpnnskdmv
      121 tliedvieml ededmpckds alqmgsikek mkagsrtgkp qepvtfkdvv vefskeewgq
      181 ldsavknlyr nvmlenfrnl nslrkahlls kpfeslkles kkkrwimeke iprktifdmk
      241 sisgeesshg vimtrltesg hpssdawkgr th
//
LOCUS       XP_054225885             272 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein 215 isoform X2 [Homo sapiens].
ACCESSION   XP_054225885
VERSION     XP_054225885.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369910.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..272
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..272
                     /product="zinc finger protein 215 isoform X2"
                     /calculated_mol_wt=31586
     Region          44..132
                     /region_name="SCAN"
                     /note="SCAN domain; pfam02023"
                     /db_xref="CDD:460417"
     Region          164..226
                     /region_name="KRAB"
                     /note="krueppel associated box; smart00349"
                     /db_xref="CDD:214630"
     CDS             1..272
                     /gene="ZNF215"
                     /gene_synonym="BAZ-2; BAZ2; ZKSCAN11; ZSCAN43"
                     /coded_by="XM_054369910.1:762..1580"
                     /db_xref="GeneID:7762"
                     /db_xref="HGNC:HGNC:13007"
                     /db_xref="MIM:605016"
ORIGIN      
        1 mqplsklmai skprnlslre qrevlradms wqqetnpvve thdseasrqk frhfqylkvs
       61 gphealsqlw elclqwlrpe ihtkkqiiel lvleqflail peevrtwvnl qhpnnskdmv
      121 tliedvieml ededmpckds alqmgsikek mkagsrtgkp qepvtfkdvv vefskeewgq
      181 ldsavknlyr nvmlenfrnl nslrkahlls kpfeslkles kkkrwimeke iprktifdmk
      241 sisgeesshg vimtrltesg hpssdawkgr th
//
LOCUS       XP_054225886            5890 aa            linear   PRI 05-AUG-2025
DEFINITION  neuroblast differentiation-associated protein AHNAK isoform X1
            [Homo sapiens].
ACCESSION   XP_054225886
VERSION     XP_054225886.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369911.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..5890
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..5890
                     /product="neuroblast differentiation-associated protein
                     AHNAK isoform X1"
                     /calculated_mol_wt=629073
     Region          22..>56
                     /region_name="PDZ_canonical"
                     /note="canonical PDZ domain; cl49608"
                     /db_xref="CDD:483948"
     Region          192..>681
                     /region_name="TamB"
                     /note="Autotransporter translocation and assembly protein
                     TamB [Intracellular trafficking, secretion, and vesicular
                     transport]; COG2911"
                     /db_xref="CDD:442155"
     Region          3050..3469
                     /region_name="AsmA"
                     /note="Uncharacterized conserved protein AsmA involved in
                     outer membrane biogenesis [Cell wall/membrane/envelope
                     biogenesis]; COG2982"
                     /db_xref="CDD:442221"
     Region          <3223..>3722
                     /region_name="TamB"
                     /note="Autotransporter translocation and assembly protein
                     TamB [Intracellular trafficking, secretion, and vesicular
                     transport]; COG2911"
                     /db_xref="CDD:442155"
     Region          4326..>4631
                     /region_name="AsmA"
                     /note="AsmA family; pfam05170"
                     /db_xref="CDD:428346"
     Region          4532..>4945
                     /region_name="AsmA"
                     /note="Uncharacterized conserved protein AsmA involved in
                     outer membrane biogenesis [Cell wall/membrane/envelope
                     biogenesis]; COG2982"
                     /db_xref="CDD:442221"
     Region          <4879..>5014
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          5109..>5658
                     /region_name="TamB"
                     /note="Autotransporter translocation and assembly protein
                     TamB [Intracellular trafficking, secretion, and vesicular
                     transport]; COG2911"
                     /db_xref="CDD:442155"
     CDS             1..5890
                     /gene="AHNAK"
                     /gene_synonym="AHNAK1; AHNAKRS; PM227"
                     /coded_by="XM_054369911.1:1194..18866"
                     /db_xref="GeneID:79026"
                     /db_xref="HGNC:HGNC:347"
                     /db_xref="MIM:103390"
ORIGIN      
        1 mekeettrel llpnwqgsgs hgltiaqrdd gvfvqevtqn spaartgvvk egdqivgati
       61 yfdnlqsgev tqllntmghh tvglklhrkg drspepgqtw trevfsscss evvlsgddee
      121 yqriyttkik prlksedgve gdlgetqsrt itvtrrvtay tvdvtgrega kdidisspef
      181 kikiprhelt eisnvdvetq sgktvirlps gsgaasptgs avdiragais asgpelqgag
      241 hsklqvtmpg ikvggsgvnv nakgldlggr ggvqvpavdi ssslggrave vqgpslesgd
      301 hgkikfptmk vpkfgvstgr egqtpkaglr vsapevsvgh kggkpgltiq apqlevsvps
      361 anieglegkl kgpqitgpsl egdlglkgak pqghigvdas apqiggsitg psvevqapdi
      421 dvqgpgskln vpkmkvpkfs vsgakgeetg idvtlptgev tvpgvsgdvs lpeiatggle
      481 gkmkgtkvkt pemiiqkpki smqdvdlslg spklkgdikv sapgvqgdvk gpqvalkgsr
      541 vdietpnleg tltgprlgsp sgktgtcris msevdlnvaa pkvkggvdvt lprvegkvkv
      601 pevdvrgpkv dvsapdveah gpewnlkmpk mkmptfstpg akgegpdvhm tlpkgdisis
      661 gpkvnveapd vnleglggkl kgpdvklpdm svktpkismp dvdlhvkgtk vkgeydvtvp
      721 klegelkgpk vdidapdvdv hgpdwhlkmp kmkmpkfsvp gfkaegpevd vnlpkadvdi
      781 sgpkidvtap dvsieepegk lkgpkfkmpe mnikvpkism pdvdlhlkgp nvkgeydvtm
      841 pkveseikvp dvelksakmd idvpdvevqg pdwhlkmpkm kmpkfsmpgf kaegpevdvn
      901 lpkadvdisg pkvgvevpdv niegpegklk gpkfkmpemn ikapkismpd vdlhmkgpkv
      961 kgeydmtvpk legdlkgpkv dvsapdvemq gpdwnlkmpk ikmpkfsmps lkgegpefdv
     1021 nlskanvdis apkvdtnapd lslegpegkl kgpkfkmpem hfrapkmslp dvdldlkgpk
     1081 mkgnvdisap kiegemqvpd vdirgpkvdi kapdvegqgl dwslkipkmk mpkfsmpslk
     1141 gegpevdvnl pkadvvvsgp kvdieapdvs legpegklkg pkfkmpemhf ktpkismpdv
     1201 dlhlkgpkvk gdvdvsvpkv egemkvpdve ikgpkmdida pdvevqgpdw hlkmpkmkmp
     1261 kfsmpgfkge grevdvnlpk adidvsgpkv dvevpdvsle gpegklkgpk fkmpemhfka
     1321 pkismpdvdl nlkgpklkgd vdvslpeveg emkvpdvdik gpkvdisapd vdvhgpdwhl
     1381 kmpkvkmpkf smpgfkgegp evdvklpkad vdvsgpkmda evpdvniegp daklkgpkfk
     1441 mpemsikpqk isipdvglhl kgpkmkgdyd vtvpkvegei kapdvdikgp kvdinapdve
     1501 vhgpdwhlkm pkvkmpkfsm pgfkgegpev dmnlpkadlg vsgpkvdidv pdvnleapeg
     1561 klkgpkfkmp smniqthkis mpdvglnlka pklktdvdvs lpkvegdlkg peidvkapkm
     1621 dvnvgdidie gpegklkgpk fkmpemhfka pkismpdvdl hlkgpkvkgd mdvsvpkveg
     1681 emkvpdvdik gpkvdidapd vevhdpdwhl kmpkmkmpkf smpgfkaegp evdvnlpkad
     1741 idvsgpsvdt dapdldiegp egklkgskfk mpklnikapk vsmpdvdlnl kgpklkgeid
     1801 asvpelegdl rgpqvdvkgp fveaevpdvd lecpdaklkg pkfkmpemhf kapkismpdv
     1861 dlhlkgpkvk gdadvsvpkl egdltgpsvg vevpdvelec pdaklkgpkf kmpdmhfkap
     1921 kismpdvdlh lkgpkvkgdv dvsvpklegd ltgpsvgvev pdvelecpda klkgpkfkmp
     1981 emhfktpkis mpdvdlhlkg pkvkgdmdvs vpkvegemkv pdvdikgpkm didapdvdvh
     2041 gpdwhlkmpk mkmpkfsmpg fkaegpevdv nlpkadvvvs gpkvdvevpd vslegpegkl
     2101 kgpklkmpem hfkapkismp dvdlhlkgpk vkgdvdvslp klegdltgps vdvevpdvel
     2161 ecpdaklkgp kfkmpemhfk tpkismpdvn lnlkgpkvkg dmdvsvpkve gemkvpdvdi
     2221 rgpkvdidap dvdvhgpdwh lkmpkmkmpk fsmpgfkgeg pevdvnlpka dvdvsgpkvd
     2281 vevpdvsleg pegklkgpkf kmpemhfktp kismpdvdfn lkgpkikgdv dvsapklege
     2341 lkgpeldvkg pkldadmpev avegpngkwk tpkfkmpdmh fkapkismpd ldlhlkspka
     2401 kgevdvdvpk legdlkgphv dvsgpdidie gpegklkgpk fkmpdmhfka pnismpdvdl
     2461 nlkgpkikgd vdvsvpeveg klevpdmnir gpkvdvnapd vqapdwhlkm pkmkmpkfsm
     2521 pgfkaegpev dvnlpkadvd isgpkvdieg pdvniegpeg klkgpklkmp emnikapkis
     2581 mpdfdlhlkg pkvkgdvdvs lpkvegdlkg pevdikgpkv dinapdvgvq gpdwhlkmpk
     2641 vkmpkfsmpg fkgegpdgdv klpkadidvs gpkvdiegpd vniegpegkl kgpkfkmpem
     2701 nikapkismp didlnlkgpk vkgdvdvslp kvegdlkgpe vdikgpkvdi dapdvdvhgp
     2761 dwhlkmpkik mpkismpgfk gegpdvdvnl pkadidvsgp kvdvecpdvn iegpegkwks
     2821 pkfkmpemhf ktpkismpdi dlnltgpkik gdvdvtgpkv egdlkgpevd lkgpkvdidv
     2881 pdvnvqgpdw hlkmpkmkmp kfsmpgfkae gpevdvnlpk advdvsgpkv dvegpdvnie
     2941 gpegklkgpk fkmpemnika pkipmpdfdl hlkgpkvkgd vdislpkveg dlkgpevdir
     3001 gpkvdidvpd vgvqgpdwhl kmpkvkmpkf smpgfkgegp dvdvnlpkad ldvsgpkvdi
     3061 dvpdvniegp egklkgpkfk mpemnikapk ismpdidlnl kgpkvkgdmd vslpkvegdm
     3121 kvpdvdikgp kvdinapdvd vqgpdwhlkm pkikmpkism pgfkgegpev dvnlpkadld
     3181 vsgpkvdvdv pdvniegpda klkgpkfkmp emnikapkis mpdldlnlkg pkmkgevdvs
     3241 lanvegdlkg paldikgpki dvdapdidih gpdaklkgpk lkmpdmhvnm pkismpeidl
     3301 nlkgsklkgd vdvsgpkleg dikapsldik gpevdvsgpk lniegkskks rfklpkfnfs
     3361 gskvqtpevd vkgkkpdidi tgpkvdinap dvevqgkvkg skfkmpflsi sspkvsmpdv
     3421 elnlkspkvk gdldiagpnl egdfkgpkvd ikapevnlna pdvdvhgpdw nlkmpkmkmp
     3481 kfsvsglkae gpdvavdlpk gdiniegpsm niegpdlnve gpegglkgpk fkmpdmnika
     3541 pkismpdidl nlkgpkvkgd vdislpkleg dlkgpevdik gpkvdinapd vdvhgpdwhl
     3601 kmpkvkmpkf smpgfkgegp evdvtlpkad idisgpnvdv dvpdvniegp daklkgpkfk
     3661 mpemnikapk ismpdfdlnl kgpkmkgdvv vslpkvegdl kgpevdikgp kvdidtpdin
     3721 iegsegkfkg pkfkipemhl kapkismpdi dlnlkgpkvk gdvdvslpkm egdlkgpevd
     3781 ikgpkvdina pdvdvqgpdw hlkmpkvkmp kfsmpgfkge gpdvdvnlpk adldvsgpkv
     3841 didvpdvnie gpegklkgpk fkmpemnika pkismpdidl nlkgpkvkgd mdvslpkveg
     3901 dmqvpdldik gpkvdinapd vdvrgpdwhl kmpkikmpki smpgfkgegp evdvnlpkad
     3961 ldvsgpkvdv dvpdvniegp daklkgpkfk mpemnikapk ismpdfdlhl kgpkvkgdvd
     4021 vslpkmegdl kapevdikgp kvdidapdvd vhgpdwhlkm pkvkmpkfsm pgfkgegpev
     4081 dvnlpkadid vsgpkvdidt pdidihgpeg klkgpkfkmp dlhlkapkis mpevdlnlkg
     4141 pkmkgdvdvs lpkvegdlkg pevdikgpkv didvpdvdvq gpdwhlkmpk vkmpkfsmpg
     4201 fkgegpdvdv nlpkadldvs gpkvdidvpd vniegpdakl kgpkfkmpem nikapkismp
     4261 dfdlhlkgpk vkgdvdvslp kvegdlkgpe vdikgpkvdi dapdvdvhgp dwhlkmpkvk
     4321 mpkfsmpgfk gegpdvdvtl pkadieisgp kvdidapdvs iegpdaklkg pkfkmpemni
     4381 kapkismpdi dfnlkgpkvk gdvdvslpkv egdlkgpeid ikgpsldidt pdvniegpeg
     4441 klkgpkfkmp emnikapkis mpdfdlhlkg pkvkgdvdvs lpkvesdlkg pevdiegpeg
     4501 klkgpkfkmp dvhfkspqis msdidlnlkg pkikgdmdis vpklegdlkg pkvdvkgpkv
     4561 gidtpdidih gpegklkgpk fkmpdlhlka pkismpevdl nlkgpkvkgd mdislpkveg
     4621 dlkgpevdir dpkvdidvpd vdvqgpdwhl kmpkvkmpkf smpgfkgegp dvdvnlpkad
     4681 idvsgpkvdv dvpdvniegp daklkgpkfk mpemsikapk ismpdidlnl kgpkvkgdvd
     4741 vtlpkvegdl kgpeadikgp kvdintpdvd vhgpdwhlkm pkvkmpkfsm pgfkgegpdv
     4801 dvslpkadid vsgpkvdvdi pdvniegpda klkgpkfkmp einikapkis ipdvdldlkg
     4861 pkvkgdfdvs vpkvegtlkg pevdlkgprl dfegpdakls gpslkmpsle isapkvtapd
     4921 vdlhlkapki gfsgpklegg evdlkgpkve apsldvhmds pdiniegpdv kipkfkkpkf
     4981 gfgakspkad ikspsldvtv peaelnletp eisvggkgkk skfkmpkihm sgpkikakkq
     5041 gfdlnvpgge idaslkapdv dvniagpdaa lkvdvkspkt kktmfgkmyf pdvefdiksp
     5101 kfkaeaplps pklegelqap dlelslpaih vegldikaka pkvkmpdvdi svpkiegdlk
     5161 gpkvqanlga pdinieglda kvktpsfgis apqvsipdvn vnlkgpkikg dvpsvglegp
     5221 dvdlqgpeak ikfpkfsmpk iripgvkmeg ggaevhaqlp slegdlrgpd vklegpdvsl
     5281 kgpgvdlpsv nlsmpkvsgp dldlnlkgps lkgdldasvp smkvhapgln lsgvggkmqv
     5341 ggdgvkvpgi dattklnvga pdvtlrgpsl qgdlavsgdi kcpkvsvgap dlsleasegs
     5401 iklpkmklpq fgistpgsdl hvnakgpqvs gelkgpgvdv nlkgprisap nvdfnlegpk
     5461 vkgslgatge ikgptvgggl pgigvqgleg nlqmpgikss gcdvnlpgvn vklptgqisg
     5521 peikgglkgs evgfhgaapd isvkgpafnm aspesdfgin lkgpkikgga dvsggvsapd
     5581 islgeghlsv kgsggewkgp qvssalnldt skfagglhfs gpkveggvkg gqiglqapgl
     5641 svsgpqghle sgsgkvtfpk mkipkftfsg relvgremgv dvhfpkaeas iqagagdgew
     5701 eesevklkks kikmpkfnfs kpkgkggvtg speasisgsk gdlksskasl gslegeaeae
     5761 asspkgkfsl fkskkprhrs nsfsderefs gpstptgtle feggevsleg gkvkgkhgkl
     5821 kfgtfgglgs kskghyevtg sddetgklqg sgvslaskks rlsssssnds gnkvgiqlpe
     5881 velsvstkke
//
LOCUS       XP_054225887            5890 aa            linear   PRI 05-AUG-2025
DEFINITION  neuroblast differentiation-associated protein AHNAK isoform X1
            [Homo sapiens].
ACCESSION   XP_054225887
VERSION     XP_054225887.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369912.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..5890
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..5890
                     /product="neuroblast differentiation-associated protein
                     AHNAK isoform X1"
                     /calculated_mol_wt=629073
     Region          22..>56
                     /region_name="PDZ_canonical"
                     /note="canonical PDZ domain; cl49608"
                     /db_xref="CDD:483948"
     Region          192..>681
                     /region_name="TamB"
                     /note="Autotransporter translocation and assembly protein
                     TamB [Intracellular trafficking, secretion, and vesicular
                     transport]; COG2911"
                     /db_xref="CDD:442155"
     Region          3050..3469
                     /region_name="AsmA"
                     /note="Uncharacterized conserved protein AsmA involved in
                     outer membrane biogenesis [Cell wall/membrane/envelope
                     biogenesis]; COG2982"
                     /db_xref="CDD:442221"
     Region          <3223..>3722
                     /region_name="TamB"
                     /note="Autotransporter translocation and assembly protein
                     TamB [Intracellular trafficking, secretion, and vesicular
                     transport]; COG2911"
                     /db_xref="CDD:442155"
     Region          4326..>4631
                     /region_name="AsmA"
                     /note="AsmA family; pfam05170"
                     /db_xref="CDD:428346"
     Region          4532..>4945
                     /region_name="AsmA"
                     /note="Uncharacterized conserved protein AsmA involved in
                     outer membrane biogenesis [Cell wall/membrane/envelope
                     biogenesis]; COG2982"
                     /db_xref="CDD:442221"
     Region          <4879..>5014
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          5109..>5658
                     /region_name="TamB"
                     /note="Autotransporter translocation and assembly protein
                     TamB [Intracellular trafficking, secretion, and vesicular
                     transport]; COG2911"
                     /db_xref="CDD:442155"
     CDS             1..5890
                     /gene="AHNAK"
                     /gene_synonym="AHNAK1; AHNAKRS; PM227"
                     /coded_by="XM_054369912.1:601..18273"
                     /db_xref="GeneID:79026"
                     /db_xref="HGNC:HGNC:347"
                     /db_xref="MIM:103390"
ORIGIN      
        1 mekeettrel llpnwqgsgs hgltiaqrdd gvfvqevtqn spaartgvvk egdqivgati
       61 yfdnlqsgev tqllntmghh tvglklhrkg drspepgqtw trevfsscss evvlsgddee
      121 yqriyttkik prlksedgve gdlgetqsrt itvtrrvtay tvdvtgrega kdidisspef
      181 kikiprhelt eisnvdvetq sgktvirlps gsgaasptgs avdiragais asgpelqgag
      241 hsklqvtmpg ikvggsgvnv nakgldlggr ggvqvpavdi ssslggrave vqgpslesgd
      301 hgkikfptmk vpkfgvstgr egqtpkaglr vsapevsvgh kggkpgltiq apqlevsvps
      361 anieglegkl kgpqitgpsl egdlglkgak pqghigvdas apqiggsitg psvevqapdi
      421 dvqgpgskln vpkmkvpkfs vsgakgeetg idvtlptgev tvpgvsgdvs lpeiatggle
      481 gkmkgtkvkt pemiiqkpki smqdvdlslg spklkgdikv sapgvqgdvk gpqvalkgsr
      541 vdietpnleg tltgprlgsp sgktgtcris msevdlnvaa pkvkggvdvt lprvegkvkv
      601 pevdvrgpkv dvsapdveah gpewnlkmpk mkmptfstpg akgegpdvhm tlpkgdisis
      661 gpkvnveapd vnleglggkl kgpdvklpdm svktpkismp dvdlhvkgtk vkgeydvtvp
      721 klegelkgpk vdidapdvdv hgpdwhlkmp kmkmpkfsvp gfkaegpevd vnlpkadvdi
      781 sgpkidvtap dvsieepegk lkgpkfkmpe mnikvpkism pdvdlhlkgp nvkgeydvtm
      841 pkveseikvp dvelksakmd idvpdvevqg pdwhlkmpkm kmpkfsmpgf kaegpevdvn
      901 lpkadvdisg pkvgvevpdv niegpegklk gpkfkmpemn ikapkismpd vdlhmkgpkv
      961 kgeydmtvpk legdlkgpkv dvsapdvemq gpdwnlkmpk ikmpkfsmps lkgegpefdv
     1021 nlskanvdis apkvdtnapd lslegpegkl kgpkfkmpem hfrapkmslp dvdldlkgpk
     1081 mkgnvdisap kiegemqvpd vdirgpkvdi kapdvegqgl dwslkipkmk mpkfsmpslk
     1141 gegpevdvnl pkadvvvsgp kvdieapdvs legpegklkg pkfkmpemhf ktpkismpdv
     1201 dlhlkgpkvk gdvdvsvpkv egemkvpdve ikgpkmdida pdvevqgpdw hlkmpkmkmp
     1261 kfsmpgfkge grevdvnlpk adidvsgpkv dvevpdvsle gpegklkgpk fkmpemhfka
     1321 pkismpdvdl nlkgpklkgd vdvslpeveg emkvpdvdik gpkvdisapd vdvhgpdwhl
     1381 kmpkvkmpkf smpgfkgegp evdvklpkad vdvsgpkmda evpdvniegp daklkgpkfk
     1441 mpemsikpqk isipdvglhl kgpkmkgdyd vtvpkvegei kapdvdikgp kvdinapdve
     1501 vhgpdwhlkm pkvkmpkfsm pgfkgegpev dmnlpkadlg vsgpkvdidv pdvnleapeg
     1561 klkgpkfkmp smniqthkis mpdvglnlka pklktdvdvs lpkvegdlkg peidvkapkm
     1621 dvnvgdidie gpegklkgpk fkmpemhfka pkismpdvdl hlkgpkvkgd mdvsvpkveg
     1681 emkvpdvdik gpkvdidapd vevhdpdwhl kmpkmkmpkf smpgfkaegp evdvnlpkad
     1741 idvsgpsvdt dapdldiegp egklkgskfk mpklnikapk vsmpdvdlnl kgpklkgeid
     1801 asvpelegdl rgpqvdvkgp fveaevpdvd lecpdaklkg pkfkmpemhf kapkismpdv
     1861 dlhlkgpkvk gdadvsvpkl egdltgpsvg vevpdvelec pdaklkgpkf kmpdmhfkap
     1921 kismpdvdlh lkgpkvkgdv dvsvpklegd ltgpsvgvev pdvelecpda klkgpkfkmp
     1981 emhfktpkis mpdvdlhlkg pkvkgdmdvs vpkvegemkv pdvdikgpkm didapdvdvh
     2041 gpdwhlkmpk mkmpkfsmpg fkaegpevdv nlpkadvvvs gpkvdvevpd vslegpegkl
     2101 kgpklkmpem hfkapkismp dvdlhlkgpk vkgdvdvslp klegdltgps vdvevpdvel
     2161 ecpdaklkgp kfkmpemhfk tpkismpdvn lnlkgpkvkg dmdvsvpkve gemkvpdvdi
     2221 rgpkvdidap dvdvhgpdwh lkmpkmkmpk fsmpgfkgeg pevdvnlpka dvdvsgpkvd
     2281 vevpdvsleg pegklkgpkf kmpemhfktp kismpdvdfn lkgpkikgdv dvsapklege
     2341 lkgpeldvkg pkldadmpev avegpngkwk tpkfkmpdmh fkapkismpd ldlhlkspka
     2401 kgevdvdvpk legdlkgphv dvsgpdidie gpegklkgpk fkmpdmhfka pnismpdvdl
     2461 nlkgpkikgd vdvsvpeveg klevpdmnir gpkvdvnapd vqapdwhlkm pkmkmpkfsm
     2521 pgfkaegpev dvnlpkadvd isgpkvdieg pdvniegpeg klkgpklkmp emnikapkis
     2581 mpdfdlhlkg pkvkgdvdvs lpkvegdlkg pevdikgpkv dinapdvgvq gpdwhlkmpk
     2641 vkmpkfsmpg fkgegpdgdv klpkadidvs gpkvdiegpd vniegpegkl kgpkfkmpem
     2701 nikapkismp didlnlkgpk vkgdvdvslp kvegdlkgpe vdikgpkvdi dapdvdvhgp
     2761 dwhlkmpkik mpkismpgfk gegpdvdvnl pkadidvsgp kvdvecpdvn iegpegkwks
     2821 pkfkmpemhf ktpkismpdi dlnltgpkik gdvdvtgpkv egdlkgpevd lkgpkvdidv
     2881 pdvnvqgpdw hlkmpkmkmp kfsmpgfkae gpevdvnlpk advdvsgpkv dvegpdvnie
     2941 gpegklkgpk fkmpemnika pkipmpdfdl hlkgpkvkgd vdislpkveg dlkgpevdir
     3001 gpkvdidvpd vgvqgpdwhl kmpkvkmpkf smpgfkgegp dvdvnlpkad ldvsgpkvdi
     3061 dvpdvniegp egklkgpkfk mpemnikapk ismpdidlnl kgpkvkgdmd vslpkvegdm
     3121 kvpdvdikgp kvdinapdvd vqgpdwhlkm pkikmpkism pgfkgegpev dvnlpkadld
     3181 vsgpkvdvdv pdvniegpda klkgpkfkmp emnikapkis mpdldlnlkg pkmkgevdvs
     3241 lanvegdlkg paldikgpki dvdapdidih gpdaklkgpk lkmpdmhvnm pkismpeidl
     3301 nlkgsklkgd vdvsgpkleg dikapsldik gpevdvsgpk lniegkskks rfklpkfnfs
     3361 gskvqtpevd vkgkkpdidi tgpkvdinap dvevqgkvkg skfkmpflsi sspkvsmpdv
     3421 elnlkspkvk gdldiagpnl egdfkgpkvd ikapevnlna pdvdvhgpdw nlkmpkmkmp
     3481 kfsvsglkae gpdvavdlpk gdiniegpsm niegpdlnve gpegglkgpk fkmpdmnika
     3541 pkismpdidl nlkgpkvkgd vdislpkleg dlkgpevdik gpkvdinapd vdvhgpdwhl
     3601 kmpkvkmpkf smpgfkgegp evdvtlpkad idisgpnvdv dvpdvniegp daklkgpkfk
     3661 mpemnikapk ismpdfdlnl kgpkmkgdvv vslpkvegdl kgpevdikgp kvdidtpdin
     3721 iegsegkfkg pkfkipemhl kapkismpdi dlnlkgpkvk gdvdvslpkm egdlkgpevd
     3781 ikgpkvdina pdvdvqgpdw hlkmpkvkmp kfsmpgfkge gpdvdvnlpk adldvsgpkv
     3841 didvpdvnie gpegklkgpk fkmpemnika pkismpdidl nlkgpkvkgd mdvslpkveg
     3901 dmqvpdldik gpkvdinapd vdvrgpdwhl kmpkikmpki smpgfkgegp evdvnlpkad
     3961 ldvsgpkvdv dvpdvniegp daklkgpkfk mpemnikapk ismpdfdlhl kgpkvkgdvd
     4021 vslpkmegdl kapevdikgp kvdidapdvd vhgpdwhlkm pkvkmpkfsm pgfkgegpev
     4081 dvnlpkadid vsgpkvdidt pdidihgpeg klkgpkfkmp dlhlkapkis mpevdlnlkg
     4141 pkmkgdvdvs lpkvegdlkg pevdikgpkv didvpdvdvq gpdwhlkmpk vkmpkfsmpg
     4201 fkgegpdvdv nlpkadldvs gpkvdidvpd vniegpdakl kgpkfkmpem nikapkismp
     4261 dfdlhlkgpk vkgdvdvslp kvegdlkgpe vdikgpkvdi dapdvdvhgp dwhlkmpkvk
     4321 mpkfsmpgfk gegpdvdvtl pkadieisgp kvdidapdvs iegpdaklkg pkfkmpemni
     4381 kapkismpdi dfnlkgpkvk gdvdvslpkv egdlkgpeid ikgpsldidt pdvniegpeg
     4441 klkgpkfkmp emnikapkis mpdfdlhlkg pkvkgdvdvs lpkvesdlkg pevdiegpeg
     4501 klkgpkfkmp dvhfkspqis msdidlnlkg pkikgdmdis vpklegdlkg pkvdvkgpkv
     4561 gidtpdidih gpegklkgpk fkmpdlhlka pkismpevdl nlkgpkvkgd mdislpkveg
     4621 dlkgpevdir dpkvdidvpd vdvqgpdwhl kmpkvkmpkf smpgfkgegp dvdvnlpkad
     4681 idvsgpkvdv dvpdvniegp daklkgpkfk mpemsikapk ismpdidlnl kgpkvkgdvd
     4741 vtlpkvegdl kgpeadikgp kvdintpdvd vhgpdwhlkm pkvkmpkfsm pgfkgegpdv
     4801 dvslpkadid vsgpkvdvdi pdvniegpda klkgpkfkmp einikapkis ipdvdldlkg
     4861 pkvkgdfdvs vpkvegtlkg pevdlkgprl dfegpdakls gpslkmpsle isapkvtapd
     4921 vdlhlkapki gfsgpklegg evdlkgpkve apsldvhmds pdiniegpdv kipkfkkpkf
     4981 gfgakspkad ikspsldvtv peaelnletp eisvggkgkk skfkmpkihm sgpkikakkq
     5041 gfdlnvpgge idaslkapdv dvniagpdaa lkvdvkspkt kktmfgkmyf pdvefdiksp
     5101 kfkaeaplps pklegelqap dlelslpaih vegldikaka pkvkmpdvdi svpkiegdlk
     5161 gpkvqanlga pdinieglda kvktpsfgis apqvsipdvn vnlkgpkikg dvpsvglegp
     5221 dvdlqgpeak ikfpkfsmpk iripgvkmeg ggaevhaqlp slegdlrgpd vklegpdvsl
     5281 kgpgvdlpsv nlsmpkvsgp dldlnlkgps lkgdldasvp smkvhapgln lsgvggkmqv
     5341 ggdgvkvpgi dattklnvga pdvtlrgpsl qgdlavsgdi kcpkvsvgap dlsleasegs
     5401 iklpkmklpq fgistpgsdl hvnakgpqvs gelkgpgvdv nlkgprisap nvdfnlegpk
     5461 vkgslgatge ikgptvgggl pgigvqgleg nlqmpgikss gcdvnlpgvn vklptgqisg
     5521 peikgglkgs evgfhgaapd isvkgpafnm aspesdfgin lkgpkikgga dvsggvsapd
     5581 islgeghlsv kgsggewkgp qvssalnldt skfagglhfs gpkveggvkg gqiglqapgl
     5641 svsgpqghle sgsgkvtfpk mkipkftfsg relvgremgv dvhfpkaeas iqagagdgew
     5701 eesevklkks kikmpkfnfs kpkgkggvtg speasisgsk gdlksskasl gslegeaeae
     5761 asspkgkfsl fkskkprhrs nsfsderefs gpstptgtle feggevsleg gkvkgkhgkl
     5821 kfgtfgglgs kskghyevtg sddetgklqg sgvslaskks rlsssssnds gnkvgiqlpe
     5881 velsvstkke
//
LOCUS       XP_054225888            5890 aa            linear   PRI 05-AUG-2025
DEFINITION  neuroblast differentiation-associated protein AHNAK isoform X1
            [Homo sapiens].
ACCESSION   XP_054225888
VERSION     XP_054225888.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369913.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..5890
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..5890
                     /product="neuroblast differentiation-associated protein
                     AHNAK isoform X1"
                     /calculated_mol_wt=629073
     Region          22..>56
                     /region_name="PDZ_canonical"
                     /note="canonical PDZ domain; cl49608"
                     /db_xref="CDD:483948"
     Region          192..>681
                     /region_name="TamB"
                     /note="Autotransporter translocation and assembly protein
                     TamB [Intracellular trafficking, secretion, and vesicular
                     transport]; COG2911"
                     /db_xref="CDD:442155"
     Region          3050..3469
                     /region_name="AsmA"
                     /note="Uncharacterized conserved protein AsmA involved in
                     outer membrane biogenesis [Cell wall/membrane/envelope
                     biogenesis]; COG2982"
                     /db_xref="CDD:442221"
     Region          <3223..>3722
                     /region_name="TamB"
                     /note="Autotransporter translocation and assembly protein
                     TamB [Intracellular trafficking, secretion, and vesicular
                     transport]; COG2911"
                     /db_xref="CDD:442155"
     Region          4326..>4631
                     /region_name="AsmA"
                     /note="AsmA family; pfam05170"
                     /db_xref="CDD:428346"
     Region          4532..>4945
                     /region_name="AsmA"
                     /note="Uncharacterized conserved protein AsmA involved in
                     outer membrane biogenesis [Cell wall/membrane/envelope
                     biogenesis]; COG2982"
                     /db_xref="CDD:442221"
     Region          <4879..>5014
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          5109..>5658
                     /region_name="TamB"
                     /note="Autotransporter translocation and assembly protein
                     TamB [Intracellular trafficking, secretion, and vesicular
                     transport]; COG2911"
                     /db_xref="CDD:442155"
     CDS             1..5890
                     /gene="AHNAK"
                     /gene_synonym="AHNAK1; AHNAKRS; PM227"
                     /coded_by="XM_054369913.1:377..18049"
                     /db_xref="GeneID:79026"
                     /db_xref="HGNC:HGNC:347"
                     /db_xref="MIM:103390"
ORIGIN      
        1 mekeettrel llpnwqgsgs hgltiaqrdd gvfvqevtqn spaartgvvk egdqivgati
       61 yfdnlqsgev tqllntmghh tvglklhrkg drspepgqtw trevfsscss evvlsgddee
      121 yqriyttkik prlksedgve gdlgetqsrt itvtrrvtay tvdvtgrega kdidisspef
      181 kikiprhelt eisnvdvetq sgktvirlps gsgaasptgs avdiragais asgpelqgag
      241 hsklqvtmpg ikvggsgvnv nakgldlggr ggvqvpavdi ssslggrave vqgpslesgd
      301 hgkikfptmk vpkfgvstgr egqtpkaglr vsapevsvgh kggkpgltiq apqlevsvps
      361 anieglegkl kgpqitgpsl egdlglkgak pqghigvdas apqiggsitg psvevqapdi
      421 dvqgpgskln vpkmkvpkfs vsgakgeetg idvtlptgev tvpgvsgdvs lpeiatggle
      481 gkmkgtkvkt pemiiqkpki smqdvdlslg spklkgdikv sapgvqgdvk gpqvalkgsr
      541 vdietpnleg tltgprlgsp sgktgtcris msevdlnvaa pkvkggvdvt lprvegkvkv
      601 pevdvrgpkv dvsapdveah gpewnlkmpk mkmptfstpg akgegpdvhm tlpkgdisis
      661 gpkvnveapd vnleglggkl kgpdvklpdm svktpkismp dvdlhvkgtk vkgeydvtvp
      721 klegelkgpk vdidapdvdv hgpdwhlkmp kmkmpkfsvp gfkaegpevd vnlpkadvdi
      781 sgpkidvtap dvsieepegk lkgpkfkmpe mnikvpkism pdvdlhlkgp nvkgeydvtm
      841 pkveseikvp dvelksakmd idvpdvevqg pdwhlkmpkm kmpkfsmpgf kaegpevdvn
      901 lpkadvdisg pkvgvevpdv niegpegklk gpkfkmpemn ikapkismpd vdlhmkgpkv
      961 kgeydmtvpk legdlkgpkv dvsapdvemq gpdwnlkmpk ikmpkfsmps lkgegpefdv
     1021 nlskanvdis apkvdtnapd lslegpegkl kgpkfkmpem hfrapkmslp dvdldlkgpk
     1081 mkgnvdisap kiegemqvpd vdirgpkvdi kapdvegqgl dwslkipkmk mpkfsmpslk
     1141 gegpevdvnl pkadvvvsgp kvdieapdvs legpegklkg pkfkmpemhf ktpkismpdv
     1201 dlhlkgpkvk gdvdvsvpkv egemkvpdve ikgpkmdida pdvevqgpdw hlkmpkmkmp
     1261 kfsmpgfkge grevdvnlpk adidvsgpkv dvevpdvsle gpegklkgpk fkmpemhfka
     1321 pkismpdvdl nlkgpklkgd vdvslpeveg emkvpdvdik gpkvdisapd vdvhgpdwhl
     1381 kmpkvkmpkf smpgfkgegp evdvklpkad vdvsgpkmda evpdvniegp daklkgpkfk
     1441 mpemsikpqk isipdvglhl kgpkmkgdyd vtvpkvegei kapdvdikgp kvdinapdve
     1501 vhgpdwhlkm pkvkmpkfsm pgfkgegpev dmnlpkadlg vsgpkvdidv pdvnleapeg
     1561 klkgpkfkmp smniqthkis mpdvglnlka pklktdvdvs lpkvegdlkg peidvkapkm
     1621 dvnvgdidie gpegklkgpk fkmpemhfka pkismpdvdl hlkgpkvkgd mdvsvpkveg
     1681 emkvpdvdik gpkvdidapd vevhdpdwhl kmpkmkmpkf smpgfkaegp evdvnlpkad
     1741 idvsgpsvdt dapdldiegp egklkgskfk mpklnikapk vsmpdvdlnl kgpklkgeid
     1801 asvpelegdl rgpqvdvkgp fveaevpdvd lecpdaklkg pkfkmpemhf kapkismpdv
     1861 dlhlkgpkvk gdadvsvpkl egdltgpsvg vevpdvelec pdaklkgpkf kmpdmhfkap
     1921 kismpdvdlh lkgpkvkgdv dvsvpklegd ltgpsvgvev pdvelecpda klkgpkfkmp
     1981 emhfktpkis mpdvdlhlkg pkvkgdmdvs vpkvegemkv pdvdikgpkm didapdvdvh
     2041 gpdwhlkmpk mkmpkfsmpg fkaegpevdv nlpkadvvvs gpkvdvevpd vslegpegkl
     2101 kgpklkmpem hfkapkismp dvdlhlkgpk vkgdvdvslp klegdltgps vdvevpdvel
     2161 ecpdaklkgp kfkmpemhfk tpkismpdvn lnlkgpkvkg dmdvsvpkve gemkvpdvdi
     2221 rgpkvdidap dvdvhgpdwh lkmpkmkmpk fsmpgfkgeg pevdvnlpka dvdvsgpkvd
     2281 vevpdvsleg pegklkgpkf kmpemhfktp kismpdvdfn lkgpkikgdv dvsapklege
     2341 lkgpeldvkg pkldadmpev avegpngkwk tpkfkmpdmh fkapkismpd ldlhlkspka
     2401 kgevdvdvpk legdlkgphv dvsgpdidie gpegklkgpk fkmpdmhfka pnismpdvdl
     2461 nlkgpkikgd vdvsvpeveg klevpdmnir gpkvdvnapd vqapdwhlkm pkmkmpkfsm
     2521 pgfkaegpev dvnlpkadvd isgpkvdieg pdvniegpeg klkgpklkmp emnikapkis
     2581 mpdfdlhlkg pkvkgdvdvs lpkvegdlkg pevdikgpkv dinapdvgvq gpdwhlkmpk
     2641 vkmpkfsmpg fkgegpdgdv klpkadidvs gpkvdiegpd vniegpegkl kgpkfkmpem
     2701 nikapkismp didlnlkgpk vkgdvdvslp kvegdlkgpe vdikgpkvdi dapdvdvhgp
     2761 dwhlkmpkik mpkismpgfk gegpdvdvnl pkadidvsgp kvdvecpdvn iegpegkwks
     2821 pkfkmpemhf ktpkismpdi dlnltgpkik gdvdvtgpkv egdlkgpevd lkgpkvdidv
     2881 pdvnvqgpdw hlkmpkmkmp kfsmpgfkae gpevdvnlpk advdvsgpkv dvegpdvnie
     2941 gpegklkgpk fkmpemnika pkipmpdfdl hlkgpkvkgd vdislpkveg dlkgpevdir
     3001 gpkvdidvpd vgvqgpdwhl kmpkvkmpkf smpgfkgegp dvdvnlpkad ldvsgpkvdi
     3061 dvpdvniegp egklkgpkfk mpemnikapk ismpdidlnl kgpkvkgdmd vslpkvegdm
     3121 kvpdvdikgp kvdinapdvd vqgpdwhlkm pkikmpkism pgfkgegpev dvnlpkadld
     3181 vsgpkvdvdv pdvniegpda klkgpkfkmp emnikapkis mpdldlnlkg pkmkgevdvs
     3241 lanvegdlkg paldikgpki dvdapdidih gpdaklkgpk lkmpdmhvnm pkismpeidl
     3301 nlkgsklkgd vdvsgpkleg dikapsldik gpevdvsgpk lniegkskks rfklpkfnfs
     3361 gskvqtpevd vkgkkpdidi tgpkvdinap dvevqgkvkg skfkmpflsi sspkvsmpdv
     3421 elnlkspkvk gdldiagpnl egdfkgpkvd ikapevnlna pdvdvhgpdw nlkmpkmkmp
     3481 kfsvsglkae gpdvavdlpk gdiniegpsm niegpdlnve gpegglkgpk fkmpdmnika
     3541 pkismpdidl nlkgpkvkgd vdislpkleg dlkgpevdik gpkvdinapd vdvhgpdwhl
     3601 kmpkvkmpkf smpgfkgegp evdvtlpkad idisgpnvdv dvpdvniegp daklkgpkfk
     3661 mpemnikapk ismpdfdlnl kgpkmkgdvv vslpkvegdl kgpevdikgp kvdidtpdin
     3721 iegsegkfkg pkfkipemhl kapkismpdi dlnlkgpkvk gdvdvslpkm egdlkgpevd
     3781 ikgpkvdina pdvdvqgpdw hlkmpkvkmp kfsmpgfkge gpdvdvnlpk adldvsgpkv
     3841 didvpdvnie gpegklkgpk fkmpemnika pkismpdidl nlkgpkvkgd mdvslpkveg
     3901 dmqvpdldik gpkvdinapd vdvrgpdwhl kmpkikmpki smpgfkgegp evdvnlpkad
     3961 ldvsgpkvdv dvpdvniegp daklkgpkfk mpemnikapk ismpdfdlhl kgpkvkgdvd
     4021 vslpkmegdl kapevdikgp kvdidapdvd vhgpdwhlkm pkvkmpkfsm pgfkgegpev
     4081 dvnlpkadid vsgpkvdidt pdidihgpeg klkgpkfkmp dlhlkapkis mpevdlnlkg
     4141 pkmkgdvdvs lpkvegdlkg pevdikgpkv didvpdvdvq gpdwhlkmpk vkmpkfsmpg
     4201 fkgegpdvdv nlpkadldvs gpkvdidvpd vniegpdakl kgpkfkmpem nikapkismp
     4261 dfdlhlkgpk vkgdvdvslp kvegdlkgpe vdikgpkvdi dapdvdvhgp dwhlkmpkvk
     4321 mpkfsmpgfk gegpdvdvtl pkadieisgp kvdidapdvs iegpdaklkg pkfkmpemni
     4381 kapkismpdi dfnlkgpkvk gdvdvslpkv egdlkgpeid ikgpsldidt pdvniegpeg
     4441 klkgpkfkmp emnikapkis mpdfdlhlkg pkvkgdvdvs lpkvesdlkg pevdiegpeg
     4501 klkgpkfkmp dvhfkspqis msdidlnlkg pkikgdmdis vpklegdlkg pkvdvkgpkv
     4561 gidtpdidih gpegklkgpk fkmpdlhlka pkismpevdl nlkgpkvkgd mdislpkveg
     4621 dlkgpevdir dpkvdidvpd vdvqgpdwhl kmpkvkmpkf smpgfkgegp dvdvnlpkad
     4681 idvsgpkvdv dvpdvniegp daklkgpkfk mpemsikapk ismpdidlnl kgpkvkgdvd
     4741 vtlpkvegdl kgpeadikgp kvdintpdvd vhgpdwhlkm pkvkmpkfsm pgfkgegpdv
     4801 dvslpkadid vsgpkvdvdi pdvniegpda klkgpkfkmp einikapkis ipdvdldlkg
     4861 pkvkgdfdvs vpkvegtlkg pevdlkgprl dfegpdakls gpslkmpsle isapkvtapd
     4921 vdlhlkapki gfsgpklegg evdlkgpkve apsldvhmds pdiniegpdv kipkfkkpkf
     4981 gfgakspkad ikspsldvtv peaelnletp eisvggkgkk skfkmpkihm sgpkikakkq
     5041 gfdlnvpgge idaslkapdv dvniagpdaa lkvdvkspkt kktmfgkmyf pdvefdiksp
     5101 kfkaeaplps pklegelqap dlelslpaih vegldikaka pkvkmpdvdi svpkiegdlk
     5161 gpkvqanlga pdinieglda kvktpsfgis apqvsipdvn vnlkgpkikg dvpsvglegp
     5221 dvdlqgpeak ikfpkfsmpk iripgvkmeg ggaevhaqlp slegdlrgpd vklegpdvsl
     5281 kgpgvdlpsv nlsmpkvsgp dldlnlkgps lkgdldasvp smkvhapgln lsgvggkmqv
     5341 ggdgvkvpgi dattklnvga pdvtlrgpsl qgdlavsgdi kcpkvsvgap dlsleasegs
     5401 iklpkmklpq fgistpgsdl hvnakgpqvs gelkgpgvdv nlkgprisap nvdfnlegpk
     5461 vkgslgatge ikgptvgggl pgigvqgleg nlqmpgikss gcdvnlpgvn vklptgqisg
     5521 peikgglkgs evgfhgaapd isvkgpafnm aspesdfgin lkgpkikgga dvsggvsapd
     5581 islgeghlsv kgsggewkgp qvssalnldt skfagglhfs gpkveggvkg gqiglqapgl
     5641 svsgpqghle sgsgkvtfpk mkipkftfsg relvgremgv dvhfpkaeas iqagagdgew
     5701 eesevklkks kikmpkfnfs kpkgkggvtg speasisgsk gdlksskasl gslegeaeae
     5761 asspkgkfsl fkskkprhrs nsfsderefs gpstptgtle feggevsleg gkvkgkhgkl
     5821 kfgtfgglgs kskghyevtg sddetgklqg sgvslaskks rlsssssnds gnkvgiqlpe
     5881 velsvstkke
//
LOCUS       XP_054225889            5890 aa            linear   PRI 05-AUG-2025
DEFINITION  neuroblast differentiation-associated protein AHNAK isoform X1
            [Homo sapiens].
ACCESSION   XP_054225889
VERSION     XP_054225889.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369914.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..5890
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..5890
                     /product="neuroblast differentiation-associated protein
                     AHNAK isoform X1"
                     /calculated_mol_wt=629073
     Region          22..>56
                     /region_name="PDZ_canonical"
                     /note="canonical PDZ domain; cl49608"
                     /db_xref="CDD:483948"
     Region          192..>681
                     /region_name="TamB"
                     /note="Autotransporter translocation and assembly protein
                     TamB [Intracellular trafficking, secretion, and vesicular
                     transport]; COG2911"
                     /db_xref="CDD:442155"
     Region          3050..3469
                     /region_name="AsmA"
                     /note="Uncharacterized conserved protein AsmA involved in
                     outer membrane biogenesis [Cell wall/membrane/envelope
                     biogenesis]; COG2982"
                     /db_xref="CDD:442221"
     Region          <3223..>3722
                     /region_name="TamB"
                     /note="Autotransporter translocation and assembly protein
                     TamB [Intracellular trafficking, secretion, and vesicular
                     transport]; COG2911"
                     /db_xref="CDD:442155"
     Region          4326..>4631
                     /region_name="AsmA"
                     /note="AsmA family; pfam05170"
                     /db_xref="CDD:428346"
     Region          4532..>4945
                     /region_name="AsmA"
                     /note="Uncharacterized conserved protein AsmA involved in
                     outer membrane biogenesis [Cell wall/membrane/envelope
                     biogenesis]; COG2982"
                     /db_xref="CDD:442221"
     Region          <4879..>5014
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          5109..>5658
                     /region_name="TamB"
                     /note="Autotransporter translocation and assembly protein
                     TamB [Intracellular trafficking, secretion, and vesicular
                     transport]; COG2911"
                     /db_xref="CDD:442155"
     CDS             1..5890
                     /gene="AHNAK"
                     /gene_synonym="AHNAK1; AHNAKRS; PM227"
                     /coded_by="XM_054369914.1:314..17986"
                     /db_xref="GeneID:79026"
                     /db_xref="HGNC:HGNC:347"
                     /db_xref="MIM:103390"
ORIGIN      
        1 mekeettrel llpnwqgsgs hgltiaqrdd gvfvqevtqn spaartgvvk egdqivgati
       61 yfdnlqsgev tqllntmghh tvglklhrkg drspepgqtw trevfsscss evvlsgddee
      121 yqriyttkik prlksedgve gdlgetqsrt itvtrrvtay tvdvtgrega kdidisspef
      181 kikiprhelt eisnvdvetq sgktvirlps gsgaasptgs avdiragais asgpelqgag
      241 hsklqvtmpg ikvggsgvnv nakgldlggr ggvqvpavdi ssslggrave vqgpslesgd
      301 hgkikfptmk vpkfgvstgr egqtpkaglr vsapevsvgh kggkpgltiq apqlevsvps
      361 anieglegkl kgpqitgpsl egdlglkgak pqghigvdas apqiggsitg psvevqapdi
      421 dvqgpgskln vpkmkvpkfs vsgakgeetg idvtlptgev tvpgvsgdvs lpeiatggle
      481 gkmkgtkvkt pemiiqkpki smqdvdlslg spklkgdikv sapgvqgdvk gpqvalkgsr
      541 vdietpnleg tltgprlgsp sgktgtcris msevdlnvaa pkvkggvdvt lprvegkvkv
      601 pevdvrgpkv dvsapdveah gpewnlkmpk mkmptfstpg akgegpdvhm tlpkgdisis
      661 gpkvnveapd vnleglggkl kgpdvklpdm svktpkismp dvdlhvkgtk vkgeydvtvp
      721 klegelkgpk vdidapdvdv hgpdwhlkmp kmkmpkfsvp gfkaegpevd vnlpkadvdi
      781 sgpkidvtap dvsieepegk lkgpkfkmpe mnikvpkism pdvdlhlkgp nvkgeydvtm
      841 pkveseikvp dvelksakmd idvpdvevqg pdwhlkmpkm kmpkfsmpgf kaegpevdvn
      901 lpkadvdisg pkvgvevpdv niegpegklk gpkfkmpemn ikapkismpd vdlhmkgpkv
      961 kgeydmtvpk legdlkgpkv dvsapdvemq gpdwnlkmpk ikmpkfsmps lkgegpefdv
     1021 nlskanvdis apkvdtnapd lslegpegkl kgpkfkmpem hfrapkmslp dvdldlkgpk
     1081 mkgnvdisap kiegemqvpd vdirgpkvdi kapdvegqgl dwslkipkmk mpkfsmpslk
     1141 gegpevdvnl pkadvvvsgp kvdieapdvs legpegklkg pkfkmpemhf ktpkismpdv
     1201 dlhlkgpkvk gdvdvsvpkv egemkvpdve ikgpkmdida pdvevqgpdw hlkmpkmkmp
     1261 kfsmpgfkge grevdvnlpk adidvsgpkv dvevpdvsle gpegklkgpk fkmpemhfka
     1321 pkismpdvdl nlkgpklkgd vdvslpeveg emkvpdvdik gpkvdisapd vdvhgpdwhl
     1381 kmpkvkmpkf smpgfkgegp evdvklpkad vdvsgpkmda evpdvniegp daklkgpkfk
     1441 mpemsikpqk isipdvglhl kgpkmkgdyd vtvpkvegei kapdvdikgp kvdinapdve
     1501 vhgpdwhlkm pkvkmpkfsm pgfkgegpev dmnlpkadlg vsgpkvdidv pdvnleapeg
     1561 klkgpkfkmp smniqthkis mpdvglnlka pklktdvdvs lpkvegdlkg peidvkapkm
     1621 dvnvgdidie gpegklkgpk fkmpemhfka pkismpdvdl hlkgpkvkgd mdvsvpkveg
     1681 emkvpdvdik gpkvdidapd vevhdpdwhl kmpkmkmpkf smpgfkaegp evdvnlpkad
     1741 idvsgpsvdt dapdldiegp egklkgskfk mpklnikapk vsmpdvdlnl kgpklkgeid
     1801 asvpelegdl rgpqvdvkgp fveaevpdvd lecpdaklkg pkfkmpemhf kapkismpdv
     1861 dlhlkgpkvk gdadvsvpkl egdltgpsvg vevpdvelec pdaklkgpkf kmpdmhfkap
     1921 kismpdvdlh lkgpkvkgdv dvsvpklegd ltgpsvgvev pdvelecpda klkgpkfkmp
     1981 emhfktpkis mpdvdlhlkg pkvkgdmdvs vpkvegemkv pdvdikgpkm didapdvdvh
     2041 gpdwhlkmpk mkmpkfsmpg fkaegpevdv nlpkadvvvs gpkvdvevpd vslegpegkl
     2101 kgpklkmpem hfkapkismp dvdlhlkgpk vkgdvdvslp klegdltgps vdvevpdvel
     2161 ecpdaklkgp kfkmpemhfk tpkismpdvn lnlkgpkvkg dmdvsvpkve gemkvpdvdi
     2221 rgpkvdidap dvdvhgpdwh lkmpkmkmpk fsmpgfkgeg pevdvnlpka dvdvsgpkvd
     2281 vevpdvsleg pegklkgpkf kmpemhfktp kismpdvdfn lkgpkikgdv dvsapklege
     2341 lkgpeldvkg pkldadmpev avegpngkwk tpkfkmpdmh fkapkismpd ldlhlkspka
     2401 kgevdvdvpk legdlkgphv dvsgpdidie gpegklkgpk fkmpdmhfka pnismpdvdl
     2461 nlkgpkikgd vdvsvpeveg klevpdmnir gpkvdvnapd vqapdwhlkm pkmkmpkfsm
     2521 pgfkaegpev dvnlpkadvd isgpkvdieg pdvniegpeg klkgpklkmp emnikapkis
     2581 mpdfdlhlkg pkvkgdvdvs lpkvegdlkg pevdikgpkv dinapdvgvq gpdwhlkmpk
     2641 vkmpkfsmpg fkgegpdgdv klpkadidvs gpkvdiegpd vniegpegkl kgpkfkmpem
     2701 nikapkismp didlnlkgpk vkgdvdvslp kvegdlkgpe vdikgpkvdi dapdvdvhgp
     2761 dwhlkmpkik mpkismpgfk gegpdvdvnl pkadidvsgp kvdvecpdvn iegpegkwks
     2821 pkfkmpemhf ktpkismpdi dlnltgpkik gdvdvtgpkv egdlkgpevd lkgpkvdidv
     2881 pdvnvqgpdw hlkmpkmkmp kfsmpgfkae gpevdvnlpk advdvsgpkv dvegpdvnie
     2941 gpegklkgpk fkmpemnika pkipmpdfdl hlkgpkvkgd vdislpkveg dlkgpevdir
     3001 gpkvdidvpd vgvqgpdwhl kmpkvkmpkf smpgfkgegp dvdvnlpkad ldvsgpkvdi
     3061 dvpdvniegp egklkgpkfk mpemnikapk ismpdidlnl kgpkvkgdmd vslpkvegdm
     3121 kvpdvdikgp kvdinapdvd vqgpdwhlkm pkikmpkism pgfkgegpev dvnlpkadld
     3181 vsgpkvdvdv pdvniegpda klkgpkfkmp emnikapkis mpdldlnlkg pkmkgevdvs
     3241 lanvegdlkg paldikgpki dvdapdidih gpdaklkgpk lkmpdmhvnm pkismpeidl
     3301 nlkgsklkgd vdvsgpkleg dikapsldik gpevdvsgpk lniegkskks rfklpkfnfs
     3361 gskvqtpevd vkgkkpdidi tgpkvdinap dvevqgkvkg skfkmpflsi sspkvsmpdv
     3421 elnlkspkvk gdldiagpnl egdfkgpkvd ikapevnlna pdvdvhgpdw nlkmpkmkmp
     3481 kfsvsglkae gpdvavdlpk gdiniegpsm niegpdlnve gpegglkgpk fkmpdmnika
     3541 pkismpdidl nlkgpkvkgd vdislpkleg dlkgpevdik gpkvdinapd vdvhgpdwhl
     3601 kmpkvkmpkf smpgfkgegp evdvtlpkad idisgpnvdv dvpdvniegp daklkgpkfk
     3661 mpemnikapk ismpdfdlnl kgpkmkgdvv vslpkvegdl kgpevdikgp kvdidtpdin
     3721 iegsegkfkg pkfkipemhl kapkismpdi dlnlkgpkvk gdvdvslpkm egdlkgpevd
     3781 ikgpkvdina pdvdvqgpdw hlkmpkvkmp kfsmpgfkge gpdvdvnlpk adldvsgpkv
     3841 didvpdvnie gpegklkgpk fkmpemnika pkismpdidl nlkgpkvkgd mdvslpkveg
     3901 dmqvpdldik gpkvdinapd vdvrgpdwhl kmpkikmpki smpgfkgegp evdvnlpkad
     3961 ldvsgpkvdv dvpdvniegp daklkgpkfk mpemnikapk ismpdfdlhl kgpkvkgdvd
     4021 vslpkmegdl kapevdikgp kvdidapdvd vhgpdwhlkm pkvkmpkfsm pgfkgegpev
     4081 dvnlpkadid vsgpkvdidt pdidihgpeg klkgpkfkmp dlhlkapkis mpevdlnlkg
     4141 pkmkgdvdvs lpkvegdlkg pevdikgpkv didvpdvdvq gpdwhlkmpk vkmpkfsmpg
     4201 fkgegpdvdv nlpkadldvs gpkvdidvpd vniegpdakl kgpkfkmpem nikapkismp
     4261 dfdlhlkgpk vkgdvdvslp kvegdlkgpe vdikgpkvdi dapdvdvhgp dwhlkmpkvk
     4321 mpkfsmpgfk gegpdvdvtl pkadieisgp kvdidapdvs iegpdaklkg pkfkmpemni
     4381 kapkismpdi dfnlkgpkvk gdvdvslpkv egdlkgpeid ikgpsldidt pdvniegpeg
     4441 klkgpkfkmp emnikapkis mpdfdlhlkg pkvkgdvdvs lpkvesdlkg pevdiegpeg
     4501 klkgpkfkmp dvhfkspqis msdidlnlkg pkikgdmdis vpklegdlkg pkvdvkgpkv
     4561 gidtpdidih gpegklkgpk fkmpdlhlka pkismpevdl nlkgpkvkgd mdislpkveg
     4621 dlkgpevdir dpkvdidvpd vdvqgpdwhl kmpkvkmpkf smpgfkgegp dvdvnlpkad
     4681 idvsgpkvdv dvpdvniegp daklkgpkfk mpemsikapk ismpdidlnl kgpkvkgdvd
     4741 vtlpkvegdl kgpeadikgp kvdintpdvd vhgpdwhlkm pkvkmpkfsm pgfkgegpdv
     4801 dvslpkadid vsgpkvdvdi pdvniegpda klkgpkfkmp einikapkis ipdvdldlkg
     4861 pkvkgdfdvs vpkvegtlkg pevdlkgprl dfegpdakls gpslkmpsle isapkvtapd
     4921 vdlhlkapki gfsgpklegg evdlkgpkve apsldvhmds pdiniegpdv kipkfkkpkf
     4981 gfgakspkad ikspsldvtv peaelnletp eisvggkgkk skfkmpkihm sgpkikakkq
     5041 gfdlnvpgge idaslkapdv dvniagpdaa lkvdvkspkt kktmfgkmyf pdvefdiksp
     5101 kfkaeaplps pklegelqap dlelslpaih vegldikaka pkvkmpdvdi svpkiegdlk
     5161 gpkvqanlga pdinieglda kvktpsfgis apqvsipdvn vnlkgpkikg dvpsvglegp
     5221 dvdlqgpeak ikfpkfsmpk iripgvkmeg ggaevhaqlp slegdlrgpd vklegpdvsl
     5281 kgpgvdlpsv nlsmpkvsgp dldlnlkgps lkgdldasvp smkvhapgln lsgvggkmqv
     5341 ggdgvkvpgi dattklnvga pdvtlrgpsl qgdlavsgdi kcpkvsvgap dlsleasegs
     5401 iklpkmklpq fgistpgsdl hvnakgpqvs gelkgpgvdv nlkgprisap nvdfnlegpk
     5461 vkgslgatge ikgptvgggl pgigvqgleg nlqmpgikss gcdvnlpgvn vklptgqisg
     5521 peikgglkgs evgfhgaapd isvkgpafnm aspesdfgin lkgpkikgga dvsggvsapd
     5581 islgeghlsv kgsggewkgp qvssalnldt skfagglhfs gpkveggvkg gqiglqapgl
     5641 svsgpqghle sgsgkvtfpk mkipkftfsg relvgremgv dvhfpkaeas iqagagdgew
     5701 eesevklkks kikmpkfnfs kpkgkggvtg speasisgsk gdlksskasl gslegeaeae
     5761 asspkgkfsl fkskkprhrs nsfsderefs gpstptgtle feggevsleg gkvkgkhgkl
     5821 kfgtfgglgs kskghyevtg sddetgklqg sgvslaskks rlsssssnds gnkvgiqlpe
     5881 velsvstkke
//
LOCUS       XP_054225890            5890 aa            linear   PRI 05-AUG-2025
DEFINITION  neuroblast differentiation-associated protein AHNAK isoform X1
            [Homo sapiens].
ACCESSION   XP_054225890
VERSION     XP_054225890.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369915.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..5890
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..5890
                     /product="neuroblast differentiation-associated protein
                     AHNAK isoform X1"
                     /calculated_mol_wt=629073
     Region          22..>56
                     /region_name="PDZ_canonical"
                     /note="canonical PDZ domain; cl49608"
                     /db_xref="CDD:483948"
     Region          192..>681
                     /region_name="TamB"
                     /note="Autotransporter translocation and assembly protein
                     TamB [Intracellular trafficking, secretion, and vesicular
                     transport]; COG2911"
                     /db_xref="CDD:442155"
     Region          3050..3469
                     /region_name="AsmA"
                     /note="Uncharacterized conserved protein AsmA involved in
                     outer membrane biogenesis [Cell wall/membrane/envelope
                     biogenesis]; COG2982"
                     /db_xref="CDD:442221"
     Region          <3223..>3722
                     /region_name="TamB"
                     /note="Autotransporter translocation and assembly protein
                     TamB [Intracellular trafficking, secretion, and vesicular
                     transport]; COG2911"
                     /db_xref="CDD:442155"
     Region          4326..>4631
                     /region_name="AsmA"
                     /note="AsmA family; pfam05170"
                     /db_xref="CDD:428346"
     Region          4532..>4945
                     /region_name="AsmA"
                     /note="Uncharacterized conserved protein AsmA involved in
                     outer membrane biogenesis [Cell wall/membrane/envelope
                     biogenesis]; COG2982"
                     /db_xref="CDD:442221"
     Region          <4879..>5014
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          5109..>5658
                     /region_name="TamB"
                     /note="Autotransporter translocation and assembly protein
                     TamB [Intracellular trafficking, secretion, and vesicular
                     transport]; COG2911"
                     /db_xref="CDD:442155"
     CDS             1..5890
                     /gene="AHNAK"
                     /gene_synonym="AHNAK1; AHNAKRS; PM227"
                     /coded_by="XM_054369915.1:298..17970"
                     /db_xref="GeneID:79026"
                     /db_xref="HGNC:HGNC:347"
                     /db_xref="MIM:103390"
ORIGIN      
        1 mekeettrel llpnwqgsgs hgltiaqrdd gvfvqevtqn spaartgvvk egdqivgati
       61 yfdnlqsgev tqllntmghh tvglklhrkg drspepgqtw trevfsscss evvlsgddee
      121 yqriyttkik prlksedgve gdlgetqsrt itvtrrvtay tvdvtgrega kdidisspef
      181 kikiprhelt eisnvdvetq sgktvirlps gsgaasptgs avdiragais asgpelqgag
      241 hsklqvtmpg ikvggsgvnv nakgldlggr ggvqvpavdi ssslggrave vqgpslesgd
      301 hgkikfptmk vpkfgvstgr egqtpkaglr vsapevsvgh kggkpgltiq apqlevsvps
      361 anieglegkl kgpqitgpsl egdlglkgak pqghigvdas apqiggsitg psvevqapdi
      421 dvqgpgskln vpkmkvpkfs vsgakgeetg idvtlptgev tvpgvsgdvs lpeiatggle
      481 gkmkgtkvkt pemiiqkpki smqdvdlslg spklkgdikv sapgvqgdvk gpqvalkgsr
      541 vdietpnleg tltgprlgsp sgktgtcris msevdlnvaa pkvkggvdvt lprvegkvkv
      601 pevdvrgpkv dvsapdveah gpewnlkmpk mkmptfstpg akgegpdvhm tlpkgdisis
      661 gpkvnveapd vnleglggkl kgpdvklpdm svktpkismp dvdlhvkgtk vkgeydvtvp
      721 klegelkgpk vdidapdvdv hgpdwhlkmp kmkmpkfsvp gfkaegpevd vnlpkadvdi
      781 sgpkidvtap dvsieepegk lkgpkfkmpe mnikvpkism pdvdlhlkgp nvkgeydvtm
      841 pkveseikvp dvelksakmd idvpdvevqg pdwhlkmpkm kmpkfsmpgf kaegpevdvn
      901 lpkadvdisg pkvgvevpdv niegpegklk gpkfkmpemn ikapkismpd vdlhmkgpkv
      961 kgeydmtvpk legdlkgpkv dvsapdvemq gpdwnlkmpk ikmpkfsmps lkgegpefdv
     1021 nlskanvdis apkvdtnapd lslegpegkl kgpkfkmpem hfrapkmslp dvdldlkgpk
     1081 mkgnvdisap kiegemqvpd vdirgpkvdi kapdvegqgl dwslkipkmk mpkfsmpslk
     1141 gegpevdvnl pkadvvvsgp kvdieapdvs legpegklkg pkfkmpemhf ktpkismpdv
     1201 dlhlkgpkvk gdvdvsvpkv egemkvpdve ikgpkmdida pdvevqgpdw hlkmpkmkmp
     1261 kfsmpgfkge grevdvnlpk adidvsgpkv dvevpdvsle gpegklkgpk fkmpemhfka
     1321 pkismpdvdl nlkgpklkgd vdvslpeveg emkvpdvdik gpkvdisapd vdvhgpdwhl
     1381 kmpkvkmpkf smpgfkgegp evdvklpkad vdvsgpkmda evpdvniegp daklkgpkfk
     1441 mpemsikpqk isipdvglhl kgpkmkgdyd vtvpkvegei kapdvdikgp kvdinapdve
     1501 vhgpdwhlkm pkvkmpkfsm pgfkgegpev dmnlpkadlg vsgpkvdidv pdvnleapeg
     1561 klkgpkfkmp smniqthkis mpdvglnlka pklktdvdvs lpkvegdlkg peidvkapkm
     1621 dvnvgdidie gpegklkgpk fkmpemhfka pkismpdvdl hlkgpkvkgd mdvsvpkveg
     1681 emkvpdvdik gpkvdidapd vevhdpdwhl kmpkmkmpkf smpgfkaegp evdvnlpkad
     1741 idvsgpsvdt dapdldiegp egklkgskfk mpklnikapk vsmpdvdlnl kgpklkgeid
     1801 asvpelegdl rgpqvdvkgp fveaevpdvd lecpdaklkg pkfkmpemhf kapkismpdv
     1861 dlhlkgpkvk gdadvsvpkl egdltgpsvg vevpdvelec pdaklkgpkf kmpdmhfkap
     1921 kismpdvdlh lkgpkvkgdv dvsvpklegd ltgpsvgvev pdvelecpda klkgpkfkmp
     1981 emhfktpkis mpdvdlhlkg pkvkgdmdvs vpkvegemkv pdvdikgpkm didapdvdvh
     2041 gpdwhlkmpk mkmpkfsmpg fkaegpevdv nlpkadvvvs gpkvdvevpd vslegpegkl
     2101 kgpklkmpem hfkapkismp dvdlhlkgpk vkgdvdvslp klegdltgps vdvevpdvel
     2161 ecpdaklkgp kfkmpemhfk tpkismpdvn lnlkgpkvkg dmdvsvpkve gemkvpdvdi
     2221 rgpkvdidap dvdvhgpdwh lkmpkmkmpk fsmpgfkgeg pevdvnlpka dvdvsgpkvd
     2281 vevpdvsleg pegklkgpkf kmpemhfktp kismpdvdfn lkgpkikgdv dvsapklege
     2341 lkgpeldvkg pkldadmpev avegpngkwk tpkfkmpdmh fkapkismpd ldlhlkspka
     2401 kgevdvdvpk legdlkgphv dvsgpdidie gpegklkgpk fkmpdmhfka pnismpdvdl
     2461 nlkgpkikgd vdvsvpeveg klevpdmnir gpkvdvnapd vqapdwhlkm pkmkmpkfsm
     2521 pgfkaegpev dvnlpkadvd isgpkvdieg pdvniegpeg klkgpklkmp emnikapkis
     2581 mpdfdlhlkg pkvkgdvdvs lpkvegdlkg pevdikgpkv dinapdvgvq gpdwhlkmpk
     2641 vkmpkfsmpg fkgegpdgdv klpkadidvs gpkvdiegpd vniegpegkl kgpkfkmpem
     2701 nikapkismp didlnlkgpk vkgdvdvslp kvegdlkgpe vdikgpkvdi dapdvdvhgp
     2761 dwhlkmpkik mpkismpgfk gegpdvdvnl pkadidvsgp kvdvecpdvn iegpegkwks
     2821 pkfkmpemhf ktpkismpdi dlnltgpkik gdvdvtgpkv egdlkgpevd lkgpkvdidv
     2881 pdvnvqgpdw hlkmpkmkmp kfsmpgfkae gpevdvnlpk advdvsgpkv dvegpdvnie
     2941 gpegklkgpk fkmpemnika pkipmpdfdl hlkgpkvkgd vdislpkveg dlkgpevdir
     3001 gpkvdidvpd vgvqgpdwhl kmpkvkmpkf smpgfkgegp dvdvnlpkad ldvsgpkvdi
     3061 dvpdvniegp egklkgpkfk mpemnikapk ismpdidlnl kgpkvkgdmd vslpkvegdm
     3121 kvpdvdikgp kvdinapdvd vqgpdwhlkm pkikmpkism pgfkgegpev dvnlpkadld
     3181 vsgpkvdvdv pdvniegpda klkgpkfkmp emnikapkis mpdldlnlkg pkmkgevdvs
     3241 lanvegdlkg paldikgpki dvdapdidih gpdaklkgpk lkmpdmhvnm pkismpeidl
     3301 nlkgsklkgd vdvsgpkleg dikapsldik gpevdvsgpk lniegkskks rfklpkfnfs
     3361 gskvqtpevd vkgkkpdidi tgpkvdinap dvevqgkvkg skfkmpflsi sspkvsmpdv
     3421 elnlkspkvk gdldiagpnl egdfkgpkvd ikapevnlna pdvdvhgpdw nlkmpkmkmp
     3481 kfsvsglkae gpdvavdlpk gdiniegpsm niegpdlnve gpegglkgpk fkmpdmnika
     3541 pkismpdidl nlkgpkvkgd vdislpkleg dlkgpevdik gpkvdinapd vdvhgpdwhl
     3601 kmpkvkmpkf smpgfkgegp evdvtlpkad idisgpnvdv dvpdvniegp daklkgpkfk
     3661 mpemnikapk ismpdfdlnl kgpkmkgdvv vslpkvegdl kgpevdikgp kvdidtpdin
     3721 iegsegkfkg pkfkipemhl kapkismpdi dlnlkgpkvk gdvdvslpkm egdlkgpevd
     3781 ikgpkvdina pdvdvqgpdw hlkmpkvkmp kfsmpgfkge gpdvdvnlpk adldvsgpkv
     3841 didvpdvnie gpegklkgpk fkmpemnika pkismpdidl nlkgpkvkgd mdvslpkveg
     3901 dmqvpdldik gpkvdinapd vdvrgpdwhl kmpkikmpki smpgfkgegp evdvnlpkad
     3961 ldvsgpkvdv dvpdvniegp daklkgpkfk mpemnikapk ismpdfdlhl kgpkvkgdvd
     4021 vslpkmegdl kapevdikgp kvdidapdvd vhgpdwhlkm pkvkmpkfsm pgfkgegpev
     4081 dvnlpkadid vsgpkvdidt pdidihgpeg klkgpkfkmp dlhlkapkis mpevdlnlkg
     4141 pkmkgdvdvs lpkvegdlkg pevdikgpkv didvpdvdvq gpdwhlkmpk vkmpkfsmpg
     4201 fkgegpdvdv nlpkadldvs gpkvdidvpd vniegpdakl kgpkfkmpem nikapkismp
     4261 dfdlhlkgpk vkgdvdvslp kvegdlkgpe vdikgpkvdi dapdvdvhgp dwhlkmpkvk
     4321 mpkfsmpgfk gegpdvdvtl pkadieisgp kvdidapdvs iegpdaklkg pkfkmpemni
     4381 kapkismpdi dfnlkgpkvk gdvdvslpkv egdlkgpeid ikgpsldidt pdvniegpeg
     4441 klkgpkfkmp emnikapkis mpdfdlhlkg pkvkgdvdvs lpkvesdlkg pevdiegpeg
     4501 klkgpkfkmp dvhfkspqis msdidlnlkg pkikgdmdis vpklegdlkg pkvdvkgpkv
     4561 gidtpdidih gpegklkgpk fkmpdlhlka pkismpevdl nlkgpkvkgd mdislpkveg
     4621 dlkgpevdir dpkvdidvpd vdvqgpdwhl kmpkvkmpkf smpgfkgegp dvdvnlpkad
     4681 idvsgpkvdv dvpdvniegp daklkgpkfk mpemsikapk ismpdidlnl kgpkvkgdvd
     4741 vtlpkvegdl kgpeadikgp kvdintpdvd vhgpdwhlkm pkvkmpkfsm pgfkgegpdv
     4801 dvslpkadid vsgpkvdvdi pdvniegpda klkgpkfkmp einikapkis ipdvdldlkg
     4861 pkvkgdfdvs vpkvegtlkg pevdlkgprl dfegpdakls gpslkmpsle isapkvtapd
     4921 vdlhlkapki gfsgpklegg evdlkgpkve apsldvhmds pdiniegpdv kipkfkkpkf
     4981 gfgakspkad ikspsldvtv peaelnletp eisvggkgkk skfkmpkihm sgpkikakkq
     5041 gfdlnvpgge idaslkapdv dvniagpdaa lkvdvkspkt kktmfgkmyf pdvefdiksp
     5101 kfkaeaplps pklegelqap dlelslpaih vegldikaka pkvkmpdvdi svpkiegdlk
     5161 gpkvqanlga pdinieglda kvktpsfgis apqvsipdvn vnlkgpkikg dvpsvglegp
     5221 dvdlqgpeak ikfpkfsmpk iripgvkmeg ggaevhaqlp slegdlrgpd vklegpdvsl
     5281 kgpgvdlpsv nlsmpkvsgp dldlnlkgps lkgdldasvp smkvhapgln lsgvggkmqv
     5341 ggdgvkvpgi dattklnvga pdvtlrgpsl qgdlavsgdi kcpkvsvgap dlsleasegs
     5401 iklpkmklpq fgistpgsdl hvnakgpqvs gelkgpgvdv nlkgprisap nvdfnlegpk
     5461 vkgslgatge ikgptvgggl pgigvqgleg nlqmpgikss gcdvnlpgvn vklptgqisg
     5521 peikgglkgs evgfhgaapd isvkgpafnm aspesdfgin lkgpkikgga dvsggvsapd
     5581 islgeghlsv kgsggewkgp qvssalnldt skfagglhfs gpkveggvkg gqiglqapgl
     5641 svsgpqghle sgsgkvtfpk mkipkftfsg relvgremgv dvhfpkaeas iqagagdgew
     5701 eesevklkks kikmpkfnfs kpkgkggvtg speasisgsk gdlksskasl gslegeaeae
     5761 asspkgkfsl fkskkprhrs nsfsderefs gpstptgtle feggevsleg gkvkgkhgkl
     5821 kfgtfgglgs kskghyevtg sddetgklqg sgvslaskks rlsssssnds gnkvgiqlpe
     5881 velsvstkke
//
LOCUS       XP_054225891            5890 aa            linear   PRI 05-AUG-2025
DEFINITION  neuroblast differentiation-associated protein AHNAK isoform X1
            [Homo sapiens].
ACCESSION   XP_054225891
VERSION     XP_054225891.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369916.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..5890
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..5890
                     /product="neuroblast differentiation-associated protein
                     AHNAK isoform X1"
                     /calculated_mol_wt=629073
     Region          22..>56
                     /region_name="PDZ_canonical"
                     /note="canonical PDZ domain; cl49608"
                     /db_xref="CDD:483948"
     Region          192..>681
                     /region_name="TamB"
                     /note="Autotransporter translocation and assembly protein
                     TamB [Intracellular trafficking, secretion, and vesicular
                     transport]; COG2911"
                     /db_xref="CDD:442155"
     Region          3050..3469
                     /region_name="AsmA"
                     /note="Uncharacterized conserved protein AsmA involved in
                     outer membrane biogenesis [Cell wall/membrane/envelope
                     biogenesis]; COG2982"
                     /db_xref="CDD:442221"
     Region          <3223..>3722
                     /region_name="TamB"
                     /note="Autotransporter translocation and assembly protein
                     TamB [Intracellular trafficking, secretion, and vesicular
                     transport]; COG2911"
                     /db_xref="CDD:442155"
     Region          4326..>4631
                     /region_name="AsmA"
                     /note="AsmA family; pfam05170"
                     /db_xref="CDD:428346"
     Region          4532..>4945
                     /region_name="AsmA"
                     /note="Uncharacterized conserved protein AsmA involved in
                     outer membrane biogenesis [Cell wall/membrane/envelope
                     biogenesis]; COG2982"
                     /db_xref="CDD:442221"
     Region          <4879..>5014
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          5109..>5658
                     /region_name="TamB"
                     /note="Autotransporter translocation and assembly protein
                     TamB [Intracellular trafficking, secretion, and vesicular
                     transport]; COG2911"
                     /db_xref="CDD:442155"
     CDS             1..5890
                     /gene="AHNAK"
                     /gene_synonym="AHNAK1; AHNAKRS; PM227"
                     /coded_by="XM_054369916.1:264..17936"
                     /db_xref="GeneID:79026"
                     /db_xref="HGNC:HGNC:347"
                     /db_xref="MIM:103390"
ORIGIN      
        1 mekeettrel llpnwqgsgs hgltiaqrdd gvfvqevtqn spaartgvvk egdqivgati
       61 yfdnlqsgev tqllntmghh tvglklhrkg drspepgqtw trevfsscss evvlsgddee
      121 yqriyttkik prlksedgve gdlgetqsrt itvtrrvtay tvdvtgrega kdidisspef
      181 kikiprhelt eisnvdvetq sgktvirlps gsgaasptgs avdiragais asgpelqgag
      241 hsklqvtmpg ikvggsgvnv nakgldlggr ggvqvpavdi ssslggrave vqgpslesgd
      301 hgkikfptmk vpkfgvstgr egqtpkaglr vsapevsvgh kggkpgltiq apqlevsvps
      361 anieglegkl kgpqitgpsl egdlglkgak pqghigvdas apqiggsitg psvevqapdi
      421 dvqgpgskln vpkmkvpkfs vsgakgeetg idvtlptgev tvpgvsgdvs lpeiatggle
      481 gkmkgtkvkt pemiiqkpki smqdvdlslg spklkgdikv sapgvqgdvk gpqvalkgsr
      541 vdietpnleg tltgprlgsp sgktgtcris msevdlnvaa pkvkggvdvt lprvegkvkv
      601 pevdvrgpkv dvsapdveah gpewnlkmpk mkmptfstpg akgegpdvhm tlpkgdisis
      661 gpkvnveapd vnleglggkl kgpdvklpdm svktpkismp dvdlhvkgtk vkgeydvtvp
      721 klegelkgpk vdidapdvdv hgpdwhlkmp kmkmpkfsvp gfkaegpevd vnlpkadvdi
      781 sgpkidvtap dvsieepegk lkgpkfkmpe mnikvpkism pdvdlhlkgp nvkgeydvtm
      841 pkveseikvp dvelksakmd idvpdvevqg pdwhlkmpkm kmpkfsmpgf kaegpevdvn
      901 lpkadvdisg pkvgvevpdv niegpegklk gpkfkmpemn ikapkismpd vdlhmkgpkv
      961 kgeydmtvpk legdlkgpkv dvsapdvemq gpdwnlkmpk ikmpkfsmps lkgegpefdv
     1021 nlskanvdis apkvdtnapd lslegpegkl kgpkfkmpem hfrapkmslp dvdldlkgpk
     1081 mkgnvdisap kiegemqvpd vdirgpkvdi kapdvegqgl dwslkipkmk mpkfsmpslk
     1141 gegpevdvnl pkadvvvsgp kvdieapdvs legpegklkg pkfkmpemhf ktpkismpdv
     1201 dlhlkgpkvk gdvdvsvpkv egemkvpdve ikgpkmdida pdvevqgpdw hlkmpkmkmp
     1261 kfsmpgfkge grevdvnlpk adidvsgpkv dvevpdvsle gpegklkgpk fkmpemhfka
     1321 pkismpdvdl nlkgpklkgd vdvslpeveg emkvpdvdik gpkvdisapd vdvhgpdwhl
     1381 kmpkvkmpkf smpgfkgegp evdvklpkad vdvsgpkmda evpdvniegp daklkgpkfk
     1441 mpemsikpqk isipdvglhl kgpkmkgdyd vtvpkvegei kapdvdikgp kvdinapdve
     1501 vhgpdwhlkm pkvkmpkfsm pgfkgegpev dmnlpkadlg vsgpkvdidv pdvnleapeg
     1561 klkgpkfkmp smniqthkis mpdvglnlka pklktdvdvs lpkvegdlkg peidvkapkm
     1621 dvnvgdidie gpegklkgpk fkmpemhfka pkismpdvdl hlkgpkvkgd mdvsvpkveg
     1681 emkvpdvdik gpkvdidapd vevhdpdwhl kmpkmkmpkf smpgfkaegp evdvnlpkad
     1741 idvsgpsvdt dapdldiegp egklkgskfk mpklnikapk vsmpdvdlnl kgpklkgeid
     1801 asvpelegdl rgpqvdvkgp fveaevpdvd lecpdaklkg pkfkmpemhf kapkismpdv
     1861 dlhlkgpkvk gdadvsvpkl egdltgpsvg vevpdvelec pdaklkgpkf kmpdmhfkap
     1921 kismpdvdlh lkgpkvkgdv dvsvpklegd ltgpsvgvev pdvelecpda klkgpkfkmp
     1981 emhfktpkis mpdvdlhlkg pkvkgdmdvs vpkvegemkv pdvdikgpkm didapdvdvh
     2041 gpdwhlkmpk mkmpkfsmpg fkaegpevdv nlpkadvvvs gpkvdvevpd vslegpegkl
     2101 kgpklkmpem hfkapkismp dvdlhlkgpk vkgdvdvslp klegdltgps vdvevpdvel
     2161 ecpdaklkgp kfkmpemhfk tpkismpdvn lnlkgpkvkg dmdvsvpkve gemkvpdvdi
     2221 rgpkvdidap dvdvhgpdwh lkmpkmkmpk fsmpgfkgeg pevdvnlpka dvdvsgpkvd
     2281 vevpdvsleg pegklkgpkf kmpemhfktp kismpdvdfn lkgpkikgdv dvsapklege
     2341 lkgpeldvkg pkldadmpev avegpngkwk tpkfkmpdmh fkapkismpd ldlhlkspka
     2401 kgevdvdvpk legdlkgphv dvsgpdidie gpegklkgpk fkmpdmhfka pnismpdvdl
     2461 nlkgpkikgd vdvsvpeveg klevpdmnir gpkvdvnapd vqapdwhlkm pkmkmpkfsm
     2521 pgfkaegpev dvnlpkadvd isgpkvdieg pdvniegpeg klkgpklkmp emnikapkis
     2581 mpdfdlhlkg pkvkgdvdvs lpkvegdlkg pevdikgpkv dinapdvgvq gpdwhlkmpk
     2641 vkmpkfsmpg fkgegpdgdv klpkadidvs gpkvdiegpd vniegpegkl kgpkfkmpem
     2701 nikapkismp didlnlkgpk vkgdvdvslp kvegdlkgpe vdikgpkvdi dapdvdvhgp
     2761 dwhlkmpkik mpkismpgfk gegpdvdvnl pkadidvsgp kvdvecpdvn iegpegkwks
     2821 pkfkmpemhf ktpkismpdi dlnltgpkik gdvdvtgpkv egdlkgpevd lkgpkvdidv
     2881 pdvnvqgpdw hlkmpkmkmp kfsmpgfkae gpevdvnlpk advdvsgpkv dvegpdvnie
     2941 gpegklkgpk fkmpemnika pkipmpdfdl hlkgpkvkgd vdislpkveg dlkgpevdir
     3001 gpkvdidvpd vgvqgpdwhl kmpkvkmpkf smpgfkgegp dvdvnlpkad ldvsgpkvdi
     3061 dvpdvniegp egklkgpkfk mpemnikapk ismpdidlnl kgpkvkgdmd vslpkvegdm
     3121 kvpdvdikgp kvdinapdvd vqgpdwhlkm pkikmpkism pgfkgegpev dvnlpkadld
     3181 vsgpkvdvdv pdvniegpda klkgpkfkmp emnikapkis mpdldlnlkg pkmkgevdvs
     3241 lanvegdlkg paldikgpki dvdapdidih gpdaklkgpk lkmpdmhvnm pkismpeidl
     3301 nlkgsklkgd vdvsgpkleg dikapsldik gpevdvsgpk lniegkskks rfklpkfnfs
     3361 gskvqtpevd vkgkkpdidi tgpkvdinap dvevqgkvkg skfkmpflsi sspkvsmpdv
     3421 elnlkspkvk gdldiagpnl egdfkgpkvd ikapevnlna pdvdvhgpdw nlkmpkmkmp
     3481 kfsvsglkae gpdvavdlpk gdiniegpsm niegpdlnve gpegglkgpk fkmpdmnika
     3541 pkismpdidl nlkgpkvkgd vdislpkleg dlkgpevdik gpkvdinapd vdvhgpdwhl
     3601 kmpkvkmpkf smpgfkgegp evdvtlpkad idisgpnvdv dvpdvniegp daklkgpkfk
     3661 mpemnikapk ismpdfdlnl kgpkmkgdvv vslpkvegdl kgpevdikgp kvdidtpdin
     3721 iegsegkfkg pkfkipemhl kapkismpdi dlnlkgpkvk gdvdvslpkm egdlkgpevd
     3781 ikgpkvdina pdvdvqgpdw hlkmpkvkmp kfsmpgfkge gpdvdvnlpk adldvsgpkv
     3841 didvpdvnie gpegklkgpk fkmpemnika pkismpdidl nlkgpkvkgd mdvslpkveg
     3901 dmqvpdldik gpkvdinapd vdvrgpdwhl kmpkikmpki smpgfkgegp evdvnlpkad
     3961 ldvsgpkvdv dvpdvniegp daklkgpkfk mpemnikapk ismpdfdlhl kgpkvkgdvd
     4021 vslpkmegdl kapevdikgp kvdidapdvd vhgpdwhlkm pkvkmpkfsm pgfkgegpev
     4081 dvnlpkadid vsgpkvdidt pdidihgpeg klkgpkfkmp dlhlkapkis mpevdlnlkg
     4141 pkmkgdvdvs lpkvegdlkg pevdikgpkv didvpdvdvq gpdwhlkmpk vkmpkfsmpg
     4201 fkgegpdvdv nlpkadldvs gpkvdidvpd vniegpdakl kgpkfkmpem nikapkismp
     4261 dfdlhlkgpk vkgdvdvslp kvegdlkgpe vdikgpkvdi dapdvdvhgp dwhlkmpkvk
     4321 mpkfsmpgfk gegpdvdvtl pkadieisgp kvdidapdvs iegpdaklkg pkfkmpemni
     4381 kapkismpdi dfnlkgpkvk gdvdvslpkv egdlkgpeid ikgpsldidt pdvniegpeg
     4441 klkgpkfkmp emnikapkis mpdfdlhlkg pkvkgdvdvs lpkvesdlkg pevdiegpeg
     4501 klkgpkfkmp dvhfkspqis msdidlnlkg pkikgdmdis vpklegdlkg pkvdvkgpkv
     4561 gidtpdidih gpegklkgpk fkmpdlhlka pkismpevdl nlkgpkvkgd mdislpkveg
     4621 dlkgpevdir dpkvdidvpd vdvqgpdwhl kmpkvkmpkf smpgfkgegp dvdvnlpkad
     4681 idvsgpkvdv dvpdvniegp daklkgpkfk mpemsikapk ismpdidlnl kgpkvkgdvd
     4741 vtlpkvegdl kgpeadikgp kvdintpdvd vhgpdwhlkm pkvkmpkfsm pgfkgegpdv
     4801 dvslpkadid vsgpkvdvdi pdvniegpda klkgpkfkmp einikapkis ipdvdldlkg
     4861 pkvkgdfdvs vpkvegtlkg pevdlkgprl dfegpdakls gpslkmpsle isapkvtapd
     4921 vdlhlkapki gfsgpklegg evdlkgpkve apsldvhmds pdiniegpdv kipkfkkpkf
     4981 gfgakspkad ikspsldvtv peaelnletp eisvggkgkk skfkmpkihm sgpkikakkq
     5041 gfdlnvpgge idaslkapdv dvniagpdaa lkvdvkspkt kktmfgkmyf pdvefdiksp
     5101 kfkaeaplps pklegelqap dlelslpaih vegldikaka pkvkmpdvdi svpkiegdlk
     5161 gpkvqanlga pdinieglda kvktpsfgis apqvsipdvn vnlkgpkikg dvpsvglegp
     5221 dvdlqgpeak ikfpkfsmpk iripgvkmeg ggaevhaqlp slegdlrgpd vklegpdvsl
     5281 kgpgvdlpsv nlsmpkvsgp dldlnlkgps lkgdldasvp smkvhapgln lsgvggkmqv
     5341 ggdgvkvpgi dattklnvga pdvtlrgpsl qgdlavsgdi kcpkvsvgap dlsleasegs
     5401 iklpkmklpq fgistpgsdl hvnakgpqvs gelkgpgvdv nlkgprisap nvdfnlegpk
     5461 vkgslgatge ikgptvgggl pgigvqgleg nlqmpgikss gcdvnlpgvn vklptgqisg
     5521 peikgglkgs evgfhgaapd isvkgpafnm aspesdfgin lkgpkikgga dvsggvsapd
     5581 islgeghlsv kgsggewkgp qvssalnldt skfagglhfs gpkveggvkg gqiglqapgl
     5641 svsgpqghle sgsgkvtfpk mkipkftfsg relvgremgv dvhfpkaeas iqagagdgew
     5701 eesevklkks kikmpkfnfs kpkgkggvtg speasisgsk gdlksskasl gslegeaeae
     5761 asspkgkfsl fkskkprhrs nsfsderefs gpstptgtle feggevsleg gkvkgkhgkl
     5821 kfgtfgglgs kskghyevtg sddetgklqg sgvslaskks rlsssssnds gnkvgiqlpe
     5881 velsvstkke
//
LOCUS       XP_054225892            5890 aa            linear   PRI 05-AUG-2025
DEFINITION  neuroblast differentiation-associated protein AHNAK isoform X1
            [Homo sapiens].
ACCESSION   XP_054225892
VERSION     XP_054225892.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369917.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..5890
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..5890
                     /product="neuroblast differentiation-associated protein
                     AHNAK isoform X1"
                     /calculated_mol_wt=629073
     Region          22..>56
                     /region_name="PDZ_canonical"
                     /note="canonical PDZ domain; cl49608"
                     /db_xref="CDD:483948"
     Region          192..>681
                     /region_name="TamB"
                     /note="Autotransporter translocation and assembly protein
                     TamB [Intracellular trafficking, secretion, and vesicular
                     transport]; COG2911"
                     /db_xref="CDD:442155"
     Region          3050..3469
                     /region_name="AsmA"
                     /note="Uncharacterized conserved protein AsmA involved in
                     outer membrane biogenesis [Cell wall/membrane/envelope
                     biogenesis]; COG2982"
                     /db_xref="CDD:442221"
     Region          <3223..>3722
                     /region_name="TamB"
                     /note="Autotransporter translocation and assembly protein
                     TamB [Intracellular trafficking, secretion, and vesicular
                     transport]; COG2911"
                     /db_xref="CDD:442155"
     Region          4326..>4631
                     /region_name="AsmA"
                     /note="AsmA family; pfam05170"
                     /db_xref="CDD:428346"
     Region          4532..>4945
                     /region_name="AsmA"
                     /note="Uncharacterized conserved protein AsmA involved in
                     outer membrane biogenesis [Cell wall/membrane/envelope
                     biogenesis]; COG2982"
                     /db_xref="CDD:442221"
     Region          <4879..>5014
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          5109..>5658
                     /region_name="TamB"
                     /note="Autotransporter translocation and assembly protein
                     TamB [Intracellular trafficking, secretion, and vesicular
                     transport]; COG2911"
                     /db_xref="CDD:442155"
     CDS             1..5890
                     /gene="AHNAK"
                     /gene_synonym="AHNAK1; AHNAKRS; PM227"
                     /coded_by="XM_054369917.1:248..17920"
                     /db_xref="GeneID:79026"
                     /db_xref="HGNC:HGNC:347"
                     /db_xref="MIM:103390"
ORIGIN      
        1 mekeettrel llpnwqgsgs hgltiaqrdd gvfvqevtqn spaartgvvk egdqivgati
       61 yfdnlqsgev tqllntmghh tvglklhrkg drspepgqtw trevfsscss evvlsgddee
      121 yqriyttkik prlksedgve gdlgetqsrt itvtrrvtay tvdvtgrega kdidisspef
      181 kikiprhelt eisnvdvetq sgktvirlps gsgaasptgs avdiragais asgpelqgag
      241 hsklqvtmpg ikvggsgvnv nakgldlggr ggvqvpavdi ssslggrave vqgpslesgd
      301 hgkikfptmk vpkfgvstgr egqtpkaglr vsapevsvgh kggkpgltiq apqlevsvps
      361 anieglegkl kgpqitgpsl egdlglkgak pqghigvdas apqiggsitg psvevqapdi
      421 dvqgpgskln vpkmkvpkfs vsgakgeetg idvtlptgev tvpgvsgdvs lpeiatggle
      481 gkmkgtkvkt pemiiqkpki smqdvdlslg spklkgdikv sapgvqgdvk gpqvalkgsr
      541 vdietpnleg tltgprlgsp sgktgtcris msevdlnvaa pkvkggvdvt lprvegkvkv
      601 pevdvrgpkv dvsapdveah gpewnlkmpk mkmptfstpg akgegpdvhm tlpkgdisis
      661 gpkvnveapd vnleglggkl kgpdvklpdm svktpkismp dvdlhvkgtk vkgeydvtvp
      721 klegelkgpk vdidapdvdv hgpdwhlkmp kmkmpkfsvp gfkaegpevd vnlpkadvdi
      781 sgpkidvtap dvsieepegk lkgpkfkmpe mnikvpkism pdvdlhlkgp nvkgeydvtm
      841 pkveseikvp dvelksakmd idvpdvevqg pdwhlkmpkm kmpkfsmpgf kaegpevdvn
      901 lpkadvdisg pkvgvevpdv niegpegklk gpkfkmpemn ikapkismpd vdlhmkgpkv
      961 kgeydmtvpk legdlkgpkv dvsapdvemq gpdwnlkmpk ikmpkfsmps lkgegpefdv
     1021 nlskanvdis apkvdtnapd lslegpegkl kgpkfkmpem hfrapkmslp dvdldlkgpk
     1081 mkgnvdisap kiegemqvpd vdirgpkvdi kapdvegqgl dwslkipkmk mpkfsmpslk
     1141 gegpevdvnl pkadvvvsgp kvdieapdvs legpegklkg pkfkmpemhf ktpkismpdv
     1201 dlhlkgpkvk gdvdvsvpkv egemkvpdve ikgpkmdida pdvevqgpdw hlkmpkmkmp
     1261 kfsmpgfkge grevdvnlpk adidvsgpkv dvevpdvsle gpegklkgpk fkmpemhfka
     1321 pkismpdvdl nlkgpklkgd vdvslpeveg emkvpdvdik gpkvdisapd vdvhgpdwhl
     1381 kmpkvkmpkf smpgfkgegp evdvklpkad vdvsgpkmda evpdvniegp daklkgpkfk
     1441 mpemsikpqk isipdvglhl kgpkmkgdyd vtvpkvegei kapdvdikgp kvdinapdve
     1501 vhgpdwhlkm pkvkmpkfsm pgfkgegpev dmnlpkadlg vsgpkvdidv pdvnleapeg
     1561 klkgpkfkmp smniqthkis mpdvglnlka pklktdvdvs lpkvegdlkg peidvkapkm
     1621 dvnvgdidie gpegklkgpk fkmpemhfka pkismpdvdl hlkgpkvkgd mdvsvpkveg
     1681 emkvpdvdik gpkvdidapd vevhdpdwhl kmpkmkmpkf smpgfkaegp evdvnlpkad
     1741 idvsgpsvdt dapdldiegp egklkgskfk mpklnikapk vsmpdvdlnl kgpklkgeid
     1801 asvpelegdl rgpqvdvkgp fveaevpdvd lecpdaklkg pkfkmpemhf kapkismpdv
     1861 dlhlkgpkvk gdadvsvpkl egdltgpsvg vevpdvelec pdaklkgpkf kmpdmhfkap
     1921 kismpdvdlh lkgpkvkgdv dvsvpklegd ltgpsvgvev pdvelecpda klkgpkfkmp
     1981 emhfktpkis mpdvdlhlkg pkvkgdmdvs vpkvegemkv pdvdikgpkm didapdvdvh
     2041 gpdwhlkmpk mkmpkfsmpg fkaegpevdv nlpkadvvvs gpkvdvevpd vslegpegkl
     2101 kgpklkmpem hfkapkismp dvdlhlkgpk vkgdvdvslp klegdltgps vdvevpdvel
     2161 ecpdaklkgp kfkmpemhfk tpkismpdvn lnlkgpkvkg dmdvsvpkve gemkvpdvdi
     2221 rgpkvdidap dvdvhgpdwh lkmpkmkmpk fsmpgfkgeg pevdvnlpka dvdvsgpkvd
     2281 vevpdvsleg pegklkgpkf kmpemhfktp kismpdvdfn lkgpkikgdv dvsapklege
     2341 lkgpeldvkg pkldadmpev avegpngkwk tpkfkmpdmh fkapkismpd ldlhlkspka
     2401 kgevdvdvpk legdlkgphv dvsgpdidie gpegklkgpk fkmpdmhfka pnismpdvdl
     2461 nlkgpkikgd vdvsvpeveg klevpdmnir gpkvdvnapd vqapdwhlkm pkmkmpkfsm
     2521 pgfkaegpev dvnlpkadvd isgpkvdieg pdvniegpeg klkgpklkmp emnikapkis
     2581 mpdfdlhlkg pkvkgdvdvs lpkvegdlkg pevdikgpkv dinapdvgvq gpdwhlkmpk
     2641 vkmpkfsmpg fkgegpdgdv klpkadidvs gpkvdiegpd vniegpegkl kgpkfkmpem
     2701 nikapkismp didlnlkgpk vkgdvdvslp kvegdlkgpe vdikgpkvdi dapdvdvhgp
     2761 dwhlkmpkik mpkismpgfk gegpdvdvnl pkadidvsgp kvdvecpdvn iegpegkwks
     2821 pkfkmpemhf ktpkismpdi dlnltgpkik gdvdvtgpkv egdlkgpevd lkgpkvdidv
     2881 pdvnvqgpdw hlkmpkmkmp kfsmpgfkae gpevdvnlpk advdvsgpkv dvegpdvnie
     2941 gpegklkgpk fkmpemnika pkipmpdfdl hlkgpkvkgd vdislpkveg dlkgpevdir
     3001 gpkvdidvpd vgvqgpdwhl kmpkvkmpkf smpgfkgegp dvdvnlpkad ldvsgpkvdi
     3061 dvpdvniegp egklkgpkfk mpemnikapk ismpdidlnl kgpkvkgdmd vslpkvegdm
     3121 kvpdvdikgp kvdinapdvd vqgpdwhlkm pkikmpkism pgfkgegpev dvnlpkadld
     3181 vsgpkvdvdv pdvniegpda klkgpkfkmp emnikapkis mpdldlnlkg pkmkgevdvs
     3241 lanvegdlkg paldikgpki dvdapdidih gpdaklkgpk lkmpdmhvnm pkismpeidl
     3301 nlkgsklkgd vdvsgpkleg dikapsldik gpevdvsgpk lniegkskks rfklpkfnfs
     3361 gskvqtpevd vkgkkpdidi tgpkvdinap dvevqgkvkg skfkmpflsi sspkvsmpdv
     3421 elnlkspkvk gdldiagpnl egdfkgpkvd ikapevnlna pdvdvhgpdw nlkmpkmkmp
     3481 kfsvsglkae gpdvavdlpk gdiniegpsm niegpdlnve gpegglkgpk fkmpdmnika
     3541 pkismpdidl nlkgpkvkgd vdislpkleg dlkgpevdik gpkvdinapd vdvhgpdwhl
     3601 kmpkvkmpkf smpgfkgegp evdvtlpkad idisgpnvdv dvpdvniegp daklkgpkfk
     3661 mpemnikapk ismpdfdlnl kgpkmkgdvv vslpkvegdl kgpevdikgp kvdidtpdin
     3721 iegsegkfkg pkfkipemhl kapkismpdi dlnlkgpkvk gdvdvslpkm egdlkgpevd
     3781 ikgpkvdina pdvdvqgpdw hlkmpkvkmp kfsmpgfkge gpdvdvnlpk adldvsgpkv
     3841 didvpdvnie gpegklkgpk fkmpemnika pkismpdidl nlkgpkvkgd mdvslpkveg
     3901 dmqvpdldik gpkvdinapd vdvrgpdwhl kmpkikmpki smpgfkgegp evdvnlpkad
     3961 ldvsgpkvdv dvpdvniegp daklkgpkfk mpemnikapk ismpdfdlhl kgpkvkgdvd
     4021 vslpkmegdl kapevdikgp kvdidapdvd vhgpdwhlkm pkvkmpkfsm pgfkgegpev
     4081 dvnlpkadid vsgpkvdidt pdidihgpeg klkgpkfkmp dlhlkapkis mpevdlnlkg
     4141 pkmkgdvdvs lpkvegdlkg pevdikgpkv didvpdvdvq gpdwhlkmpk vkmpkfsmpg
     4201 fkgegpdvdv nlpkadldvs gpkvdidvpd vniegpdakl kgpkfkmpem nikapkismp
     4261 dfdlhlkgpk vkgdvdvslp kvegdlkgpe vdikgpkvdi dapdvdvhgp dwhlkmpkvk
     4321 mpkfsmpgfk gegpdvdvtl pkadieisgp kvdidapdvs iegpdaklkg pkfkmpemni
     4381 kapkismpdi dfnlkgpkvk gdvdvslpkv egdlkgpeid ikgpsldidt pdvniegpeg
     4441 klkgpkfkmp emnikapkis mpdfdlhlkg pkvkgdvdvs lpkvesdlkg pevdiegpeg
     4501 klkgpkfkmp dvhfkspqis msdidlnlkg pkikgdmdis vpklegdlkg pkvdvkgpkv
     4561 gidtpdidih gpegklkgpk fkmpdlhlka pkismpevdl nlkgpkvkgd mdislpkveg
     4621 dlkgpevdir dpkvdidvpd vdvqgpdwhl kmpkvkmpkf smpgfkgegp dvdvnlpkad
     4681 idvsgpkvdv dvpdvniegp daklkgpkfk mpemsikapk ismpdidlnl kgpkvkgdvd
     4741 vtlpkvegdl kgpeadikgp kvdintpdvd vhgpdwhlkm pkvkmpkfsm pgfkgegpdv
     4801 dvslpkadid vsgpkvdvdi pdvniegpda klkgpkfkmp einikapkis ipdvdldlkg
     4861 pkvkgdfdvs vpkvegtlkg pevdlkgprl dfegpdakls gpslkmpsle isapkvtapd
     4921 vdlhlkapki gfsgpklegg evdlkgpkve apsldvhmds pdiniegpdv kipkfkkpkf
     4981 gfgakspkad ikspsldvtv peaelnletp eisvggkgkk skfkmpkihm sgpkikakkq
     5041 gfdlnvpgge idaslkapdv dvniagpdaa lkvdvkspkt kktmfgkmyf pdvefdiksp
     5101 kfkaeaplps pklegelqap dlelslpaih vegldikaka pkvkmpdvdi svpkiegdlk
     5161 gpkvqanlga pdinieglda kvktpsfgis apqvsipdvn vnlkgpkikg dvpsvglegp
     5221 dvdlqgpeak ikfpkfsmpk iripgvkmeg ggaevhaqlp slegdlrgpd vklegpdvsl
     5281 kgpgvdlpsv nlsmpkvsgp dldlnlkgps lkgdldasvp smkvhapgln lsgvggkmqv
     5341 ggdgvkvpgi dattklnvga pdvtlrgpsl qgdlavsgdi kcpkvsvgap dlsleasegs
     5401 iklpkmklpq fgistpgsdl hvnakgpqvs gelkgpgvdv nlkgprisap nvdfnlegpk
     5461 vkgslgatge ikgptvgggl pgigvqgleg nlqmpgikss gcdvnlpgvn vklptgqisg
     5521 peikgglkgs evgfhgaapd isvkgpafnm aspesdfgin lkgpkikgga dvsggvsapd
     5581 islgeghlsv kgsggewkgp qvssalnldt skfagglhfs gpkveggvkg gqiglqapgl
     5641 svsgpqghle sgsgkvtfpk mkipkftfsg relvgremgv dvhfpkaeas iqagagdgew
     5701 eesevklkks kikmpkfnfs kpkgkggvtg speasisgsk gdlksskasl gslegeaeae
     5761 asspkgkfsl fkskkprhrs nsfsderefs gpstptgtle feggevsleg gkvkgkhgkl
     5821 kfgtfgglgs kskghyevtg sddetgklqg sgvslaskks rlsssssnds gnkvgiqlpe
     5881 velsvstkke
//
LOCUS       XP_054225893            5823 aa            linear   PRI 05-AUG-2025
DEFINITION  neuroblast differentiation-associated protein AHNAK isoform X2
            [Homo sapiens].
ACCESSION   XP_054225893
VERSION     XP_054225893.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369918.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..5823
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..5823
                     /product="neuroblast differentiation-associated protein
                     AHNAK isoform X2"
                     /calculated_mol_wt=621807
     Region          22..>56
                     /region_name="PDZ_canonical"
                     /note="canonical PDZ domain; cl49608"
                     /db_xref="CDD:483948"
     Region          192..>681
                     /region_name="TamB"
                     /note="Autotransporter translocation and assembly protein
                     TamB [Intracellular trafficking, secretion, and vesicular
                     transport]; COG2911"
                     /db_xref="CDD:442155"
     Region          2983..3402
                     /region_name="AsmA"
                     /note="Uncharacterized conserved protein AsmA involved in
                     outer membrane biogenesis [Cell wall/membrane/envelope
                     biogenesis]; COG2982"
                     /db_xref="CDD:442221"
     Region          <3156..>3655
                     /region_name="TamB"
                     /note="Autotransporter translocation and assembly protein
                     TamB [Intracellular trafficking, secretion, and vesicular
                     transport]; COG2911"
                     /db_xref="CDD:442155"
     Region          4259..>4564
                     /region_name="AsmA"
                     /note="AsmA family; pfam05170"
                     /db_xref="CDD:428346"
     Region          4465..>4878
                     /region_name="AsmA"
                     /note="Uncharacterized conserved protein AsmA involved in
                     outer membrane biogenesis [Cell wall/membrane/envelope
                     biogenesis]; COG2982"
                     /db_xref="CDD:442221"
     Region          <4812..>4947
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          5042..>5591
                     /region_name="TamB"
                     /note="Autotransporter translocation and assembly protein
                     TamB [Intracellular trafficking, secretion, and vesicular
                     transport]; COG2911"
                     /db_xref="CDD:442155"
     CDS             1..5823
                     /gene="AHNAK"
                     /gene_synonym="AHNAK1; AHNAKRS; PM227"
                     /coded_by="XM_054369918.1:1194..18665"
                     /db_xref="GeneID:79026"
                     /db_xref="HGNC:HGNC:347"
                     /db_xref="MIM:103390"
ORIGIN      
        1 mekeettrel llpnwqgsgs hgltiaqrdd gvfvqevtqn spaartgvvk egdqivgati
       61 yfdnlqsgev tqllntmghh tvglklhrkg drspepgqtw trevfsscss evvlsgddee
      121 yqriyttkik prlksedgve gdlgetqsrt itvtrrvtay tvdvtgrega kdidisspef
      181 kikiprhelt eisnvdvetq sgktvirlps gsgaasptgs avdiragais asgpelqgag
      241 hsklqvtmpg ikvggsgvnv nakgldlggr ggvqvpavdi ssslggrave vqgpslesgd
      301 hgkikfptmk vpkfgvstgr egqtpkaglr vsapevsvgh kggkpgltiq apqlevsvps
      361 anieglegkl kgpqitgpsl egdlglkgak pqghigvdas apqiggsitg psvevqapdi
      421 dvqgpgskln vpkmkvpkfs vsgakgeetg idvtlptgev tvpgvsgdvs lpeiatggle
      481 gkmkgtkvkt pemiiqkpki smqdvdlslg spklkgdikv sapgvqgdvk gpqvalkgsr
      541 vdietpnleg tltgprlgsp sgktgtcris msevdlnvaa pkvkggvdvt lprvegkvkv
      601 pevdvrgpkv dvsapdveah gpewnlkmpk mkmptfstpg akgegpdvhm tlpkgdisis
      661 gpkvnveapd vnleglggkl kgpdvklpdm svktpkismp dvdlhvkgtk vkgeydvtvp
      721 klegelkgpk vdidapdvdv hgpdwhlkmp kmkmpkfsvp gfkaegpevd vnlpkadvdi
      781 sgpkidvtap dvsieepegk lkgpkfkmpe mnikvpkism pdvdlhlkgp nvkgeydvtm
      841 pkveseikvp dvelksakmd idvpdvevqg pdwhlkmpkm kmpkfsmpgf kaegpevdvn
      901 lpkadvdisg pkvgvevpdv niegpegklk gpkfkmpemn ikapkismpd vdlhmkgpkv
      961 kgeydmtvpk legdlkgpkv dvsapdvemq gpdwnlkmpk ikmpkfsmps lkgegpefdv
     1021 nlskanvdis apkvdtnapd lslegpegkl kgpkfkmpem hfrapkmslp dvdldlkgpk
     1081 mkgnvdisap kiegemqvpd vdirgpkvdi kapdvegqgl dwslkipkmk mpkfsmpslk
     1141 gegpevdvnl pkadvvvsgp kvdieapdvs legpegklkg pkfkmpemhf ktpkismpdv
     1201 dlhlkgpkvk gdvdvsvpkv egemkvpdve ikgpkmdida pdvevqgpdw hlkmpkmkmp
     1261 kfsmpgfkge grevdvnlpk adidvsgpkv dvevpdvsle gpegklkgpk fkmpemhfka
     1321 pkismpdvdl nlkgpklkgd vdvslpeveg emkvpdvdik gpkvdisapd vdvhgpdwhl
     1381 kmpkvkmpkf smpgfkgegp evdvklpkad vdvsgpkmda evpdvniegp daklkgpkfk
     1441 mpemsikpqk isipdvglhl kgpkmkgdyd vtvpkvegei kapdvdikgp kvdinapdve
     1501 vhgpdwhlkm pkvkmpkfsm pgfkgegpev dmnlpkadlg vsgpkvdidv pdvnleapeg
     1561 klkgpkfkmp smniqthkis mpdvglnlka pklktdvdvs lpkvegdlkg peidvkapkm
     1621 dvnvgdidie gpegklkgpk fkmpemhfka pkismpdvdl hlkgpkvkgd mdvsvpkveg
     1681 emkvpdvdik gpkvdidapd vevhdpdwhl kmpkmkmpkf smpgfkaegp evdvnlpkad
     1741 idvsgpsvdt dapdldiegp egklkgskfk mpklnikapk vsmpdvdlnl kgpklkgeid
     1801 asvpelegdl rgpqvdvkgp fveaevpdvd lecpdaklkg pkfkmpemhf kapkismpdv
     1861 dlhlkgpkvk gdadvsvpkl egdltgpsvg vevpdvelec pdaklkgpkf kmpdmhfkap
     1921 kismpdvdlh lkgpkvkgdv dvsvpkvege mkvpdvdikg pkmdidapdv dvhgpdwhlk
     1981 mpkmkmpkfs mpgfkaegpe vdvnlpkadv vvsgpkvdve vpdvslegpe gklkgpklkm
     2041 pemhfkapki smpdvdlhlk gpkvkgdvdv slpklegdlt gpsvdvevpd velecpdakl
     2101 kgpkfkmpem hfktpkismp dvnlnlkgpk vkgdmdvsvp kvegemkvpd vdirgpkvdi
     2161 dapdvdvhgp dwhlkmpkmk mpkfsmpgfk gegpevdvnl pkadvdvsgp kvdvevpdvs
     2221 legpegklkg pkfkmpemhf ktpkismpdv dfnlkgpkik gdvdvsapkl egelkgpeld
     2281 vkgpkldadm pevavegpng kwktpkfkmp dmhfkapkis mpdldlhlks pkakgevdvd
     2341 vpklegdlkg phvdvsgpdi diegpegklk gpkfkmpdmh fkapnismpd vdlnlkgpki
     2401 kgdvdvsvpe vegklevpdm nirgpkvdvn apdvqapdwh lkmpkmkmpk fsmpgfkaeg
     2461 pevdvnlpka dvdisgpkvd iegpdvnieg pegklkgpkl kmpemnikap kismpdfdlh
     2521 lkgpkvkgdv dvslpkvegd lkgpevdikg pkvdinapdv gvqgpdwhlk mpkvkmpkfs
     2581 mpgfkgegpd gdvklpkadi dvsgpkvdie gpdvniegpe gklkgpkfkm pemnikapki
     2641 smpdidlnlk gpkvkgdvdv slpkvegdlk gpevdikgpk vdidapdvdv hgpdwhlkmp
     2701 kikmpkismp gfkgegpdvd vnlpkadidv sgpkvdvecp dvniegpegk wkspkfkmpe
     2761 mhfktpkism pdidlnltgp kikgdvdvtg pkvegdlkgp evdlkgpkvd idvpdvnvqg
     2821 pdwhlkmpkm kmpkfsmpgf kaegpevdvn lpkadvdvsg pkvdvegpdv niegpegklk
     2881 gpkfkmpemn ikapkipmpd fdlhlkgpkv kgdvdislpk vegdlkgpev dirgpkvdid
     2941 vpdvgvqgpd whlkmpkvkm pkfsmpgfkg egpdvdvnlp kadldvsgpk vdidvpdvni
     3001 egpegklkgp kfkmpemnik apkismpdid lnlkgpkvkg dmdvslpkve gdmkvpdvdi
     3061 kgpkvdinap dvdvqgpdwh lkmpkikmpk ismpgfkgeg pevdvnlpka dldvsgpkvd
     3121 vdvpdvnieg pdaklkgpkf kmpemnikap kismpdldln lkgpkmkgev dvslanvegd
     3181 lkgpaldikg pkidvdapdi dihgpdaklk gpklkmpdmh vnmpkismpe idlnlkgskl
     3241 kgdvdvsgpk legdikapsl dikgpevdvs gpklniegks kksrfklpkf nfsgskvqtp
     3301 evdvkgkkpd iditgpkvdi napdvevqgk vkgskfkmpf lsisspkvsm pdvelnlksp
     3361 kvkgdldiag pnlegdfkgp kvdikapevn lnapdvdvhg pdwnlkmpkm kmpkfsvsgl
     3421 kaegpdvavd lpkgdinieg psmniegpdl nvegpegglk gpkfkmpdmn ikapkismpd
     3481 idlnlkgpkv kgdvdislpk legdlkgpev dikgpkvdin apdvdvhgpd whlkmpkvkm
     3541 pkfsmpgfkg egpevdvtlp kadidisgpn vdvdvpdvni egpdaklkgp kfkmpemnik
     3601 apkismpdfd lnlkgpkmkg dvvvslpkve gdlkgpevdi kgpkvdidtp diniegsegk
     3661 fkgpkfkipe mhlkapkism pdidlnlkgp kvkgdvdvsl pkmegdlkgp evdikgpkvd
     3721 inapdvdvqg pdwhlkmpkv kmpkfsmpgf kgegpdvdvn lpkadldvsg pkvdidvpdv
     3781 niegpegklk gpkfkmpemn ikapkismpd idlnlkgpkv kgdmdvslpk vegdmqvpdl
     3841 dikgpkvdin apdvdvrgpd whlkmpkikm pkismpgfkg egpevdvnlp kadldvsgpk
     3901 vdvdvpdvni egpdaklkgp kfkmpemnik apkismpdfd lhlkgpkvkg dvdvslpkme
     3961 gdlkapevdi kgpkvdidap dvdvhgpdwh lkmpkvkmpk fsmpgfkgeg pevdvnlpka
     4021 didvsgpkvd idtpdidihg pegklkgpkf kmpdlhlkap kismpevdln lkgpkmkgdv
     4081 dvslpkvegd lkgpevdikg pkvdidvpdv dvqgpdwhlk mpkvkmpkfs mpgfkgegpd
     4141 vdvnlpkadl dvsgpkvdid vpdvniegpd aklkgpkfkm pemnikapki smpdfdlhlk
     4201 gpkvkgdvdv slpkvegdlk gpevdikgpk vdidapdvdv hgpdwhlkmp kvkmpkfsmp
     4261 gfkgegpdvd vtlpkadiei sgpkvdidap dvsiegpdak lkgpkfkmpe mnikapkism
     4321 pdidfnlkgp kvkgdvdvsl pkvegdlkgp eidikgpsld idtpdvnieg pegklkgpkf
     4381 kmpemnikap kismpdfdlh lkgpkvkgdv dvslpkvesd lkgpevdieg pegklkgpkf
     4441 kmpdvhfksp qismsdidln lkgpkikgdm disvpklegd lkgpkvdvkg pkvgidtpdi
     4501 dihgpegklk gpkfkmpdlh lkapkismpe vdlnlkgpkv kgdmdislpk vegdlkgpev
     4561 dirdpkvdid vpdvdvqgpd whlkmpkvkm pkfsmpgfkg egpdvdvnlp kadidvsgpk
     4621 vdvdvpdvni egpdaklkgp kfkmpemsik apkismpdid lnlkgpkvkg dvdvtlpkve
     4681 gdlkgpeadi kgpkvdintp dvdvhgpdwh lkmpkvkmpk fsmpgfkgeg pdvdvslpka
     4741 didvsgpkvd vdipdvnieg pdaklkgpkf kmpeinikap kisipdvdld lkgpkvkgdf
     4801 dvsvpkvegt lkgpevdlkg prldfegpda klsgpslkmp sleisapkvt apdvdlhlka
     4861 pkigfsgpkl eggevdlkgp kveapsldvh mdspdinieg pdvkipkfkk pkfgfgaksp
     4921 kadikspsld vtvpeaelnl etpeisvggk gkkskfkmpk ihmsgpkika kkqgfdlnvp
     4981 ggeidaslka pdvdvniagp daalkvdvks pktkktmfgk myfpdvefdi kspkfkaeap
     5041 lpspklegel qapdlelslp aihvegldik akapkvkmpd vdisvpkieg dlkgpkvqan
     5101 lgapdinieg ldakvktpsf gisapqvsip dvnvnlkgpk ikgdvpsvgl egpdvdlqgp
     5161 eakikfpkfs mpkiripgvk megggaevha qlpslegdlr gpdvklegpd vslkgpgvdl
     5221 psvnlsmpkv sgpdldlnlk gpslkgdlda svpsmkvhap glnlsgvggk mqvggdgvkv
     5281 pgidattkln vgapdvtlrg pslqgdlavs gdikcpkvsv gapdlsleas egsiklpkmk
     5341 lpqfgistpg sdlhvnakgp qvsgelkgpg vdvnlkgpri sapnvdfnle gpkvkgslga
     5401 tgeikgptvg gglpgigvqg legnlqmpgi kssgcdvnlp gvnvklptgq isgpeikggl
     5461 kgsevgfhga apdisvkgpa fnmaspesdf ginlkgpkik ggadvsggvs apdislgegh
     5521 lsvkgsggew kgpqvssaln ldtskfaggl hfsgpkvegg vkggqiglqa pglsvsgpqg
     5581 hlesgsgkvt fpkmkipkft fsgrelvgre mgvdvhfpka easiqagagd geweesevkl
     5641 kkskikmpkf nfskpkgkgg vtgspeasis gskgdlkssk aslgslegea eaeasspkgk
     5701 fslfkskkpr hrsnsfsder efsgpstptg tlefeggevs leggkvkgkh gklkfgtfgg
     5761 lgskskghye vtgsddetgk lqgsgvslas kksrlsssss ndsgnkvgiq lpevelsvst
     5821 kke
//
LOCUS       XP_054225894             149 aa            linear   PRI 05-AUG-2025
DEFINITION  neuroblast differentiation-associated protein AHNAK isoform X3
            [Homo sapiens].
ACCESSION   XP_054225894
VERSION     XP_054225894.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369919.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..149
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..149
                     /product="neuroblast differentiation-associated protein
                     AHNAK isoform X3"
                     /calculated_mol_wt=15930
     Region          27..92
                     /region_name="PDZ_canonical"
                     /note="canonical PDZ domain; cl49608"
                     /db_xref="CDD:483948"
     CDS             1..149
                     /gene="AHNAK"
                     /gene_synonym="AHNAK1; AHNAKRS; PM227"
                     /coded_by="XM_054369919.1:381..830"
                     /db_xref="GeneID:79026"
                     /db_xref="HGNC:HGNC:347"
                     /db_xref="MIM:103390"
ORIGIN      
        1 mekeettrel llpnwqgsgs hgltiaqrdd gvfvqevtqn spaartgvvk egdqivgati
       61 yfdnlqsgev tqllntmghh tvglklhrkg drspepgqtw trevfsscss evvlntpqps
      121 aleckdqnkq keassqagav svstpnagl
//
LOCUS       XP_054225895             149 aa            linear   PRI 05-AUG-2025
DEFINITION  neuroblast differentiation-associated protein AHNAK isoform X3
            [Homo sapiens].
ACCESSION   XP_054225895
VERSION     XP_054225895.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369920.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..149
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..149
                     /product="neuroblast differentiation-associated protein
                     AHNAK isoform X3"
                     /calculated_mol_wt=15930
     Region          27..92
                     /region_name="PDZ_canonical"
                     /note="canonical PDZ domain; cl49608"
                     /db_xref="CDD:483948"
     CDS             1..149
                     /gene="AHNAK"
                     /gene_synonym="AHNAK1; AHNAKRS; PM227"
                     /coded_by="XM_054369920.1:199..648"
                     /db_xref="GeneID:79026"
                     /db_xref="HGNC:HGNC:347"
                     /db_xref="MIM:103390"
ORIGIN      
        1 mekeettrel llpnwqgsgs hgltiaqrdd gvfvqevtqn spaartgvvk egdqivgati
       61 yfdnlqsgev tqllntmghh tvglklhrkg drspepgqtw trevfsscss evvlntpqps
      121 aleckdqnkq keassqagav svstpnagl
//
LOCUS       XP_054225896             517 aa            linear   PRI 05-AUG-2025
DEFINITION  dolichyl pyrophosphate Glc1Man9GlcNAc2
            alpha-1,3-glucosyltransferase isoform X1 [Homo sapiens].
ACCESSION   XP_054225896
VERSION     XP_054225896.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369921.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..517
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..517
                     /product="dolichyl pyrophosphate Glc1Man9GlcNAc2
                     alpha-1,3-glucosyltransferase isoform X1"
                     /calculated_mol_wt=59309
     Region          23..501
                     /region_name="Alg6_Alg8"
                     /note="ALG6, ALG8 glycosyltransferase family; pfam03155"
                     /db_xref="CDD:460831"
     CDS             1..517
                     /gene="ALG8"
                     /gene_synonym="CDG1H; PCLD3"
                     /coded_by="XM_054369921.1:883..2436"
                     /db_xref="GeneID:79053"
                     /db_xref="HGNC:HGNC:23161"
                     /db_xref="MIM:608103"
ORIGIN      
        1 mdvgprlkaw kprsnhemvv cihhstdfev hrnwlaiths lpisqwyyea tsewtldypp
       61 ffawfeyils hvakyfdqem lnvhnlnyss srtllfqrfs vifmdvlfvy avrecckcid
      121 gkkvgkelte kpkfilsvll lwnfgllivd hihfqyngfl fglmllsiar lfqkrhmega
      181 flfavllhfk hiylyvapay gvyllrsycf taskpdgsir wksfsfvrvi slglvvflvs
      241 alslgpflal nqlpqvfsrl fpfkrglcha ywapnfwaly naldkvlsvi glklkfldpn
      301 nipkasmtsg lvqqfqhtvl psvtplatli ctliailpsi fclwfkpqgp rgflrcltlc
      361 alssfmfgwh vhekaillai lpmsllsvgk agdasiflil tttghyslfp llftapelpi
      421 killmllfti ysisslktlf rkekplfnwm etfyllglgp levccefvfp ftswkvkypf
      481 ipllltsvyc avgityawfk lyvsvlidsa igktkkq
//
LOCUS       XP_054225897             458 aa            linear   PRI 05-AUG-2025
DEFINITION  dolichyl pyrophosphate Glc1Man9GlcNAc2
            alpha-1,3-glucosyltransferase isoform X2 [Homo sapiens].
ACCESSION   XP_054225897
VERSION     XP_054225897.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369922.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..458
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..458
                     /product="dolichyl pyrophosphate Glc1Man9GlcNAc2
                     alpha-1,3-glucosyltransferase isoform X2"
                     /calculated_mol_wt=52402
     Region          23..444
                     /region_name="Alg6_Alg8"
                     /note="ALG6, ALG8 glycosyltransferase family; pfam03155"
                     /db_xref="CDD:460831"
     CDS             1..458
                     /gene="ALG8"
                     /gene_synonym="CDG1H; PCLD3"
                     /coded_by="XM_054369922.1:850..2226"
                     /db_xref="GeneID:79053"
                     /db_xref="HGNC:HGNC:23161"
                     /db_xref="MIM:608103"
ORIGIN      
        1 mdvgprlkaw kprsnhemvv cihhstdfev hrnwlaiths lpisqwyyea tsewtldypp
       61 ffawfeyils hvakyfdqem lnvhnlnyss srtllfqrfs vifmdvlfvy avrecckcid
      121 gkkvgkelte kpkfilsvll lwnfgllivd hihfqyngfl fglmllsiar lfqkrhmega
      181 flfavllhfk hiylyvapay gvyllrsycf taskpdgsir wksfsfvrvi slglvvflvs
      241 alslgpflal nqlpqvfsrl fpfkrglcha ywapnfwaly naldkvlsvi glklkfldpn
      301 nipkasmtsg lvqqfqhtvl psvtplatli ctliailpsi fclwfkpqgp rgflrcltlc
      361 alssfmfgwh vhekaillai lpmsllsvgk agdasiflil tttghyslfp llftapelpi
      421 killmllfti ysisslktlf rrsftlvaqa gvqwhdls
//
LOCUS       XP_054225898             150 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane gamma-carboxyglutamic acid protein 4 isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225898
VERSION     XP_054225898.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369923.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..150
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..150
                     /product="transmembrane gamma-carboxyglutamic acid protein
                     4 isoform X1"
                     /calculated_mol_wt=17367
     Region          33..96
                     /region_name="GLA"
                     /note="Domain containing Gla (gamma-carboxyglutamate)
                     residues; smart00069"
                     /db_xref="CDD:214503"
     CDS             1..150
                     /gene="PRRG4"
                     /gene_synonym="PRGP4; TMG4"
                     /coded_by="XM_054369923.1:270..722"
                     /db_xref="GeneID:79056"
                     /db_xref="HGNC:HGNC:30799"
                     /db_xref="MIM:611690"
ORIGIN      
        1 mftllvllsq lptvtlgfph cargpkaskh ageevftske eanffihrrl lynrfdlelf
       61 tpgnlerecn eelcnyeear eifvdedkti afwqeysakg pttksalqps mkgggtlpps
      121 fsedlrrlpc lhchllwrmq dyllmnrqwr
//
LOCUS       XP_054225899             137 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 223 isoform X1 [Homo sapiens].
ACCESSION   XP_054225899
VERSION     XP_054225899.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369924.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..137
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..137
                     /product="transmembrane protein 223 isoform X1"
                     /calculated_mol_wt=15162
     Region          32..>109
                     /region_name="TMEM70"
                     /note="TMEM70/TMEM186/TMEM223 protein family; pfam06979"
                     /db_xref="CDD:462058"
     CDS             1..137
                     /gene="TMEM223"
                     /gene_synonym="Mrx15"
                     /coded_by="XM_054369924.1:13..426"
                     /db_xref="GeneID:79064"
                     /db_xref="HGNC:HGNC:28464"
                     /db_xref="MIM:620434"
ORIGIN      
        1 maapwrrwpt gllavlrpll tcrplqgttl qrdvllfehd rgrfftilgl fcagqgvfwa
       61 smavaavsrp pvpvqpldae vpnrgpfdlr salwryglav gcgaigysti rnrqkqqlmt
      121 hsnnaqhqka rksnlrg
//
LOCUS       XP_054225900             137 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 223 isoform X1 [Homo sapiens].
ACCESSION   XP_054225900
VERSION     XP_054225900.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369925.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..137
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..137
                     /product="transmembrane protein 223 isoform X1"
                     /calculated_mol_wt=15162
     Region          32..>109
                     /region_name="TMEM70"
                     /note="TMEM70/TMEM186/TMEM223 protein family; pfam06979"
                     /db_xref="CDD:462058"
     CDS             1..137
                     /gene="TMEM223"
                     /gene_synonym="Mrx15"
                     /coded_by="XM_054369925.1:13..426"
                     /db_xref="GeneID:79064"
                     /db_xref="HGNC:HGNC:28464"
                     /db_xref="MIM:620434"
ORIGIN      
        1 maapwrrwpt gllavlrpll tcrplqgttl qrdvllfehd rgrfftilgl fcagqgvfwa
       61 smavaavsrp pvpvqpldae vpnrgpfdlr salwryglav gcgaigysti rnrqkqqlmt
      121 hsnnaqhqka rksnlrg
//
LOCUS       XP_054225901             137 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 223 isoform X1 [Homo sapiens].
ACCESSION   XP_054225901
VERSION     XP_054225901.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369926.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..137
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..137
                     /product="transmembrane protein 223 isoform X1"
                     /calculated_mol_wt=15162
     Region          32..>109
                     /region_name="TMEM70"
                     /note="TMEM70/TMEM186/TMEM223 protein family; pfam06979"
                     /db_xref="CDD:462058"
     CDS             1..137
                     /gene="TMEM223"
                     /gene_synonym="Mrx15"
                     /coded_by="XM_054369926.1:13..426"
                     /db_xref="GeneID:79064"
                     /db_xref="HGNC:HGNC:28464"
                     /db_xref="MIM:620434"
ORIGIN      
        1 maapwrrwpt gllavlrpll tcrplqgttl qrdvllfehd rgrfftilgl fcagqgvfwa
       61 smavaavsrp pvpvqpldae vpnrgpfdlr salwryglav gcgaigysti rnrqkqqlmt
      121 hsnnaqhqka rksnlrg
//
LOCUS       XP_054225902             360 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 86 isoform X1 [Homo sapiens].
ACCESSION   XP_054225902
VERSION     XP_054225902.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369927.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..360
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..360
                     /product="coiled-coil domain-containing protein 86 isoform
                     X1"
                     /calculated_mol_wt=40105
     Region          3..>204
                     /region_name="dnaA"
                     /note="chromosomal replication initiator protein DnaA;
                     cl42516"
                     /db_xref="CDD:455861"
     Region          236..338
                     /region_name="Cgr1"
                     /note="Cgr1 family; pfam03879"
                     /db_xref="CDD:427562"
     CDS             1..360
                     /gene="CCDC86"
                     /gene_synonym="Cgr1"
                     /coded_by="XM_054369927.1:580..1662"
                     /db_xref="GeneID:79080"
                     /db_xref="HGNC:HGNC:28359"
                     /db_xref="MIM:611293"
ORIGIN      
        1 mdtplrrsrr lgglrpespe sltsvsrtrr alvefesnpe etrepgspps vqraglgspe
       61 rppktspgsp rlqqgagles pqgqpepgaa spqrqqdlhl espqrqpeys pesprcqpkp
      121 seeapkcsqd qgvlaselaq nkeeltpgap qhqlppvpgs pepypgqqap gpepsqplle
      181 ltprapgspr gqhepskppp agetvtggfg akkrkgsssq apaskklnke elpvipkgkp
      241 ksgrvwkdrs kkrfsqmlqd kplrtswqrk mkerqerkla kdfarhleee kerrrqekkq
      301 rraenlkrrl enerkaevvq virnpaklkr akkkqlrsie krdtlallqk qppqqpaaki
//
LOCUS       XP_054225903             141 aa            linear   PRI 05-AUG-2025
DEFINITION  calcitonin isoform X1 [Homo sapiens].
ACCESSION   XP_054225903
VERSION     XP_054225903.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369928.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..141
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..141
                     /product="calcitonin isoform X1"
                     /calculated_mol_wt=15336
     Region          1..120
                     /region_name="Calc_CGRP_IAPP"
                     /note="Calcitonin / CGRP / IAPP family; pfam00214"
                     /db_xref="CDD:459715"
     CDS             1..141
                     /gene="CALCA"
                     /gene_synonym="CALC1; CGRP; CGRP-alpha; CGRP-I; CGRP1; CT;
                     KC; PCT"
                     /coded_by="XM_054369928.1:117..542"
                     /db_xref="GeneID:796"
                     /db_xref="HGNC:HGNC:1437"
                     /db_xref="MIM:114130"
ORIGIN      
        1 mgfqkfspfl alsilvllqa gslhaapfrs alesspadpa tlsedearll laalvqdyvq
       61 mkaseleqeq eregssldsp rskrcgnlst cmlgtytqdf nkfhtfpqta igvgapgkkr
      121 dmssdlerdh rphvsmpqna n
//
LOCUS       XP_054225904             141 aa            linear   PRI 05-AUG-2025
DEFINITION  calcitonin isoform X1 [Homo sapiens].
ACCESSION   XP_054225904
VERSION     XP_054225904.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369929.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..141
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..141
                     /product="calcitonin isoform X1"
                     /calculated_mol_wt=15336
     Region          1..120
                     /region_name="Calc_CGRP_IAPP"
                     /note="Calcitonin / CGRP / IAPP family; pfam00214"
                     /db_xref="CDD:459715"
     CDS             1..141
                     /gene="CALCA"
                     /gene_synonym="CALC1; CGRP; CGRP-alpha; CGRP-I; CGRP1; CT;
                     KC; PCT"
                     /coded_by="XM_054369929.1:141..566"
                     /db_xref="GeneID:796"
                     /db_xref="HGNC:HGNC:1437"
                     /db_xref="MIM:114130"
ORIGIN      
        1 mgfqkfspfl alsilvllqa gslhaapfrs alesspadpa tlsedearll laalvqdyvq
       61 mkaseleqeq eregssldsp rskrcgnlst cmlgtytqdf nkfhtfpqta igvgapgkkr
      121 dmssdlerdh rphvsmpqna n
//
LOCUS       XP_054225907             213 aa            linear   PRI 05-AUG-2025
DEFINITION  protein FAM118B isoform X3 [Homo sapiens].
ACCESSION   XP_054225907
VERSION     XP_054225907.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369932.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..213
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..213
                     /product="protein FAM118B isoform X3"
                     /calculated_mol_wt=23272
     Region          43..>178
                     /region_name="SIR2"
                     /note="SIR2 superfamily of proteins includes silent
                     information regulator 2 (Sir2) enzymes which catalyze
                     NAD+-dependent protein/histone deacetylation, where the
                     acetyl group from the lysine epsilon-amino group is
                     transferred to the ADP-ribose moiety of NAD+; cl00195"
                     /db_xref="CDD:444738"
     CDS             1..213
                     /gene="FAM118B"
                     /coded_by="XM_054369932.1:184..825"
                     /db_xref="GeneID:79607"
                     /db_xref="HGNC:HGNC:26110"
                     /db_xref="MIM:616587"
ORIGIN      
        1 mastgsqasd ideifgffnd gepptkkprk llpslktkkp relvlvigtg isaavapqvp
       61 alkswkgliq alldaaidfd lledeeskkf qkclhedknl vhvahdliqk lsprtsnvrs
      121 tffkdclyev fddleskmed sgkqllqsvl hlmengalvl ttnfdnllel yaadqgkqle
      181 sldltdekkv lspaklvgly vccagprvgs gea
//
LOCUS       XP_054225908             196 aa            linear   PRI 05-AUG-2025
DEFINITION  protein FAM118B isoform X4 [Homo sapiens].
ACCESSION   XP_054225908
VERSION     XP_054225908.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369933.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..196
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..196
                     /product="protein FAM118B isoform X4"
                     /calculated_mol_wt=22203
     Region          <41..146
                     /region_name="SIR2"
                     /note="SIR2 superfamily of proteins includes silent
                     information regulator 2 (Sir2) enzymes which catalyze
                     NAD+-dependent protein/histone deacetylation, where the
                     acetyl group from the lysine epsilon-amino group is
                     transferred to the ADP-ribose moiety of NAD+; cl00195"
                     /db_xref="CDD:444738"
     CDS             1..196
                     /gene="FAM118B"
                     /coded_by="XM_054369933.1:173..763"
                     /db_xref="GeneID:79607"
                     /db_xref="HGNC:HGNC:26110"
                     /db_xref="MIM:616587"
ORIGIN      
        1 mqqirgnsln pltllmrkrc salpswlgym cvvqvlewaq ekrklsvlhi hgvytnpsgi
       61 vlhpagyqnv lrntevmrei qklyenksfl flgcgwtvdd ttfqalflea vkhksdlehf
      121 mlvrrgdvde fkklrenmld kgikvisygd dyadlpeyfk rltceistrg tsagmvregq
      181 lngssaahse irgcst
//
LOCUS       XP_054225909             397 aa            linear   PRI 05-AUG-2025
DEFINITION  protein RIC-3 isoform X1 [Homo sapiens].
ACCESSION   XP_054225909
VERSION     XP_054225909.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369934.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..397
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..397
                     /product="protein RIC-3 isoform X1"
                     /calculated_mol_wt=44259
     Region          24..165
                     /region_name="RIC3"
                     /note="Resistance to inhibitors of cholinesterase homolog
                     3; pfam15361"
                     /db_xref="CDD:464671"
     CDS             1..397
                     /gene="RIC3"
                     /gene_synonym="AYST720; PRO1385; RIC-3"
                     /coded_by="XM_054369934.1:37..1230"
                     /db_xref="GeneID:79608"
                     /db_xref="HGNC:HGNC:30338"
                     /db_xref="MIM:610509"
ORIGIN      
        1 maystvqrva lasglvlals lllpkaflsr gkrqeppptp egklgrfppm mhhhqapsdg
       61 qtpgarfqrs hlaeafakak gsgggagggg sgrglmgqii piygfgifly ilyilfklsk
      121 akttaedgky ytampgnthr kitsfelaql qeklketeaa meklinrvgp ngestqtdhs
      181 dvyvhclgvf ttkwldclif lsraqtvtsd qekrllhqlr eitrvmkegk fidrfspeke
      241 aeeapymedw egypeetypi ydlsdcikrr qetilvdypd pkelsaeeia ermgmieeee
      301 sdhlgweslp tdpraqedns vtscdpkpet csccfheded pavlaenagf sadsypeqee
      361 ttkeewsqdf kdeglgistn kaytgsmlrk rnpqgle
//
LOCUS       XP_054225910             368 aa            linear   PRI 05-AUG-2025
DEFINITION  protein RIC-3 isoform X2 [Homo sapiens].
ACCESSION   XP_054225910
VERSION     XP_054225910.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369935.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..368
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..368
                     /product="protein RIC-3 isoform X2"
                     /calculated_mol_wt=40947
     Region          24..165
                     /region_name="RIC3"
                     /note="Resistance to inhibitors of cholinesterase homolog
                     3; pfam15361"
                     /db_xref="CDD:464671"
     CDS             1..368
                     /gene="RIC3"
                     /gene_synonym="AYST720; PRO1385; RIC-3"
                     /coded_by="XM_054369935.1:37..1143"
                     /db_xref="GeneID:79608"
                     /db_xref="HGNC:HGNC:30338"
                     /db_xref="MIM:610509"
ORIGIN      
        1 maystvqrva lasglvlals lllpkaflsr gkrqeppptp egklgrfppm mhhhqapsdg
       61 qtpgarfqrs hlaeafakak gsgggagggg sgrglmgqii piygfgifly ilyilfklsk
      121 akttaedgky ytampgnthr kitsfelaql qeklketeaa meklinrvgp ngeraqtvts
      181 dqekrllhql reitrvmkeg kfidrfspek eaeeapymed wegypeetyp iydlsdcikr
      241 rqetilvdyp dpkelsaeei aermgmieee esdhlgwesl ptdpraqedn svtscdpkpe
      301 tcsccfhede dpavlaenag fsadsypeqe ettkeewsqd fkdeglgist nkaytgsmlr
      361 krnpqgle
//
LOCUS       XP_054225911             222 aa            linear   PRI 05-AUG-2025
DEFINITION  protein RIC-3 isoform X3 [Homo sapiens].
ACCESSION   XP_054225911
VERSION     XP_054225911.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369936.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..222
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..222
                     /product="protein RIC-3 isoform X3"
                     /calculated_mol_wt=25659
     CDS             1..222
                     /gene="RIC3"
                     /gene_synonym="AYST720; PRO1385; RIC-3"
                     /coded_by="XM_054369936.1:83..751"
                     /db_xref="GeneID:79608"
                     /db_xref="HGNC:HGNC:30338"
                     /db_xref="MIM:610509"
ORIGIN      
        1 mvrdqnalrt vwksnmcrlk rqefvisraq tvtsdqekrl lhqlreitrv mkegkfidrf
       61 spekeaeeap ymedwegype etypiydlsd cikrrqetil vdypdpkels aeeiaermgm
      121 ieeeesdhlg weslptdpra qednsvtscd pkpetcsccf hededpavla enagfsadsy
      181 peqeettkee wsqdfkdegl gistnkaytg smlrkrnpqg le
//
LOCUS       XP_054225912             192 aa            linear   PRI 05-AUG-2025
DEFINITION  protein RIC-3 isoform X4 [Homo sapiens].
ACCESSION   XP_054225912
VERSION     XP_054225912.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369937.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..192
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..192
                     /product="protein RIC-3 isoform X4"
                     /calculated_mol_wt=20614
     Region          24..165
                     /region_name="RIC3"
                     /note="Resistance to inhibitors of cholinesterase homolog
                     3; pfam15361"
                     /db_xref="CDD:464671"
     CDS             1..192
                     /gene="RIC3"
                     /gene_synonym="AYST720; PRO1385; RIC-3"
                     /coded_by="XM_054369937.1:37..615"
                     /db_xref="GeneID:79608"
                     /db_xref="HGNC:HGNC:30338"
                     /db_xref="MIM:610509"
ORIGIN      
        1 maystvqrva lasglvlals lllpkaflsr gkrqeppptp egklgrfppm mhhhqapsdg
       61 qtpgarfqrs hlaeafakak gsgggagggg sgrglmgqii piygfgifly ilyilfklsk
      121 akttaedgky ytampgnthr kitsfelaql qeklketeaa meklinrvgp ngeschlqsg
      181 wrttqaiids yv
//
LOCUS       XP_054225913             184 aa            linear   PRI 05-AUG-2025
DEFINITION  protein RIC-3 isoform X5 [Homo sapiens].
ACCESSION   XP_054225913
VERSION     XP_054225913.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369938.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..184
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..184
                     /product="protein RIC-3 isoform X5"
                     /calculated_mol_wt=19731
     Region          24..165
                     /region_name="RIC3"
                     /note="Resistance to inhibitors of cholinesterase homolog
                     3; pfam15361"
                     /db_xref="CDD:464671"
     CDS             1..184
                     /gene="RIC3"
                     /gene_synonym="AYST720; PRO1385; RIC-3"
                     /coded_by="XM_054369938.1:37..591"
                     /db_xref="GeneID:79608"
                     /db_xref="HGNC:HGNC:30338"
                     /db_xref="MIM:610509"
ORIGIN      
        1 maystvqrva lasglvlals lllpkaflsr gkrqeppptp egklgrfppm mhhhqapsdg
       61 qtpgarfqrs hlaeafakak gsgggagggg sgrglmgqii piygfgifly ilyilfklsk
      121 akttaedgky ytampgnthr kitsfelaql qeklketeaa meklinrvgp ngersecpay
      181 slek
//
LOCUS       XP_054225914             184 aa            linear   PRI 05-AUG-2025
DEFINITION  protein RIC-3 isoform X5 [Homo sapiens].
ACCESSION   XP_054225914
VERSION     XP_054225914.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369939.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..184
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..184
                     /product="protein RIC-3 isoform X5"
                     /calculated_mol_wt=19731
     Region          24..165
                     /region_name="RIC3"
                     /note="Resistance to inhibitors of cholinesterase homolog
                     3; pfam15361"
                     /db_xref="CDD:464671"
     CDS             1..184
                     /gene="RIC3"
                     /gene_synonym="AYST720; PRO1385; RIC-3"
                     /coded_by="XM_054369939.1:37..591"
                     /db_xref="GeneID:79608"
                     /db_xref="HGNC:HGNC:30338"
                     /db_xref="MIM:610509"
ORIGIN      
        1 maystvqrva lasglvlals lllpkaflsr gkrqeppptp egklgrfppm mhhhqapsdg
       61 qtpgarfqrs hlaeafakak gsgggagggg sgrglmgqii piygfgifly ilyilfklsk
      121 akttaedgky ytampgnthr kitsfelaql qeklketeaa meklinrvgp ngersecpay
      181 slek
//
LOCUS       XP_054225915            4300 aa            linear   PRI 05-AUG-2025
DEFINITION  cytoplasmic dynein 2 heavy chain 1 isoform X1 [Homo sapiens].
ACCESSION   XP_054225915
VERSION     XP_054225915.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369940.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4300
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..4300
                     /product="cytoplasmic dynein 2 heavy chain 1 isoform X1"
                     /calculated_mol_wt=491800
     Region          <234..674
                     /region_name="DHC_N1"
                     /note="Dynein heavy chain, N-terminal region 1; pfam08385"
                     /db_xref="CDD:462457"
     Region          1120..1518
                     /region_name="DHC_N2"
                     /note="Dynein heavy chain, N-terminal region 2; pfam08393"
                     /db_xref="CDD:462462"
     Region          <1361..4009
                     /region_name="DYN1"
                     /note="Dynein, heavy chain [Cytoskeleton]; COG5245"
                     /db_xref="CDD:227570"
     Region          1651..1986
                     /region_name="AAA_6"
                     /note="Hydrolytic ATP binding site of dynein motor region;
                     pfam12774"
                     /db_xref="CDD:463697"
     Region          4004..4297
                     /region_name="Dynein_C"
                     /note="Dynein heavy chain C-terminal domain; pfam18199"
                     /db_xref="CDD:465677"
     CDS             1..4300
                     /gene="DYNC2H1"
                     /gene_synonym="ATD3; DHC1b; DHC2; DNCH2; DYH1B; hdhc11;
                     SRPS2B; SRTD3"
                     /coded_by="XM_054369940.1:150..13052"
                     /db_xref="GeneID:79659"
                     /db_xref="HGNC:HGNC:2962"
                     /db_xref="MIM:603297"
ORIGIN      
        1 mangtadvrk lfiftttqny fglmselwdq pllcnclein nflddgnqml lrvqrsdagi
       61 sfsntiefgd tkdkvlvffk lrpevitden lhdnilvssm lespisslyq avrqvfapml
      121 lkdqewsrnf dpklqnllse leaglgivlr rsdtnltklk fkeddtrgil tpsdefqfwi
      181 eqahrgnkqi skeranyfke lfetiarefy nldslsllev vdlvettqdv vddvwrqteh
      241 dhypesrmlh lldiiggsfg rfvqkklgtl nlwedpyylv keslkagisi ceqwvivcnh
      301 ltgqvwqryv phpwknekyf petldklgkr leevlairti hekflyflpa seekiicltr
      361 vfepftglnp vqynpytepl wkaavsqyek iiapaeqkia gklknyisei qdspqqllqa
      421 flkykelvkr ptiskelmle retllarlvd sikdfrldfe nrcrgipgda sgplsgknls
      481 evvnsivwvr qlelkvddti kiaeallsdl pgfrcfhqsa kdlldqlkly eqeqfddwsr
      541 diqsglsdsr sglcieassr imeldsndgl lkvhysdrlv illrevrqls algfvipaki
      601 qqvaniaqkf ckqaiilkqv ahfynsidqq miqsqrpmml qsalafeqii knskagsggk
      661 sqitwdnpke legyiqklqn aaerlatenr klrkwhttfc ekvvvlmnid llrqqqrwkd
      721 glqelrtgla tveaqgfqas dmhawkqhwn hqlykalehq yqmglealne nlpeinidlt
      781 ykqgrlqfrp pfeeirakyy remkrfigip nqfkgvgeag desifsimid rnasgfltif
      841 skaedlfrrl savlhqhkew ivigqvdmea lvekhlftvh dweknfkalk ikgkeverlp
      901 savkvdclni ncnpvktvid dliqklfdll vlslkksiqa hlheidtfvt eamevltimp
      961 qsveeigdan lqysklqerk peilplfqea edknrllrtv agggletisn lkakwdkfel
     1021 mmeshqlmik dqievmkgnv ksrlqiyyqe lekfkarwdq lkpgddviet gqhntldksa
     1081 klikekkief ddlevtrkkl vddchhfrle epnfslassi skdiescaqi wafyeefqqg
     1141 fqemanedwi tfrtktylfe eflmnwhdrl rkveehsvmt vklqsevdky kivipilkyv
     1201 rgehlspdhw ldlfrllglp rgtslekllf gdllrvadti vakaadlkdl nsraqgevti
     1261 realreldlw gvgavftlid yedsqsrtmk likdwkdivn qvgdnrcllq slkdspyykg
     1321 fedkvsiwer klaeldeylq nlnhiqrkwv ylepifgrga lpkeqtrfnr vdedfrsimt
     1381 dikkdnrvtt ltthagirns lltildqlqr cqrslnefle ekrsafprfy figdddllei
     1441 lgqstnpsvi qshlkklfag insvcfdeks khitamksle gevvpfknkv plsnnvetwl
     1501 ndlalemkkt leqllkecvt tgrssqgavd pslfpsqilc laeqikfted venaikdhsl
     1561 hqietqlvnk leqytnidts sedpgntesg ilelklkali ldiihnidvv kqlnqiqvht
     1621 tedwawkkql rfymksdhtc cvqmvdsefq ytyeyqgnas klvytpltdk cyltltqamk
     1681 mglggnpygp agtgktesvk alggllgrqv lvfncdegid vksmgrifvg lvkcgawgcf
     1741 defnrleesv lsavsmqiqt iqdalknhrt vcellgkeve vnsnsgifit mnpagkgygg
     1801 rqklpdnlkq lfrpvamshp dneliaevil ysegfkdakv lsrklvaifn lsrelltpqq
     1861 hydwglralk tvlrgsgnll rqlnksgttq naneshivvq alrlntmskf tftdctrfda
     1921 likdvfpgie lkeveydels aalkqvfeea nyeiipnqik kalelyeqlc qrmgvvivgp
     1981 sgagkstlwr mlraalcktg kvvkqytmnp kampryqllg hidmdtrews dgvltnsarq
     2041 vvrepqdvss wiicdgdidp ewieslnsvl ddnrlltmps geriqfgpnv nfvfethdls
     2101 caspatisrm gmiflsdeet dlnslikswl rnqpaeyrnn lenwigdyfe kalqwvlkqn
     2161 dyvvetslvg tvmnglshlh gcrdhdefii nlirglggnl nmksrleftk evfhwaresp
     2221 pdfhkpmdty ydstrgrlat yvlkkpedlt addfsngltl pviqtpdmqr gldyfkpwls
     2281 sdtkqpfilv gpegcgkgml lryafsqlrs tqiatvhcsa qttsrhllqk lsqtcmvist
     2341 ntgrvyrpkd cerlvlylkd inlpkldkwg tstlvaflqq vltyqgfyde nlewvgleni
     2401 qivasmsagg rlgrhklttr ftsivrlcsi dypereqlqt iygaylepvl hknlknhsiw
     2461 gssskiylla gsmvqvyeqv rakftvddys hyfftpcilt qwvlglfryd legdyvleiv
     2521 ayearrlfrd kivgakelhl fdiiltsvfq gdwgsdildn msdsfyvtwg arhnsgaraa
     2581 pgqplpphgk plgklnstdl kdvikkglih ygrdnqnldi llfhevleym sridrvlsfp
     2641 ggslllagrs gvgrrtitsl vshmhgavlf spkisrgyel kqfkndlkhv lqlagieaqq
     2701 vvllledyqf vhptflemin sllssgevpg lytleelepl llplkdqasq dgffgpvfny
     2761 ftyriqqnlh ivlimdsans nfmincesnp alhkkcqvlw megwsnssmk kipemlfset
     2821 gggekyndkk rkeekkknsv dpdflksfll ihesckayga tpsqymtflh vysaissskk
     2881 kellkrqshl qagvsklnea kalvdelnrk ageqsvllkt kqdeadaalq mitvsmqdas
     2941 eqktelerlk hriaeevvki eerknkidde lkevqplvne aklavgnikp eslseirslr
     3001 mppdvirdil egvlrlmgif dtswvsmksf lakrgvredi atfdarnisk eiresveell
     3061 fknkgsfdpk nakrastaaa plaawvkani qyshvlerih pleteqagle snlkktedrk
     3121 rkleellnsv gqkvselkek fqsrtseaak leaevskaqe tikaaevlin qldrehkrwn
     3181 aqvveiteel atlpkraqla aafitylsaa peslrktcle ewtksaglek fdlrrflcte
     3241 seqliwkseg lpsddlsien alvilqsrvc pflidpssqa tewlkthlkd srlevinqqd
     3301 snfitalela vrfgktliiq emdgvepvly pllrrdlvaq gpryvvqigd kiidyneefr
     3361 lflstrnpnp fippdaasiv tevnftttrs glrgqllalt iqhekpdlee qktkllqqee
     3421 dkkiqlakle eslletlats qgnilenkdl ieslnqtkas saliqeslke syklqisldq
     3481 erdaylplae saskmyfiis dlskinnmyr fslaaflrlf qralqnkqds enteqriqsl
     3541 isslqhmvye yicrclfkad qlmfalhfvr gmhpelfqen ewdtftgvvv gdmlrkadsq
     3601 qkirdqlpsw idqerswava tlkialpsly qtlcfedaal wrtyynnsmc eqefpsilak
     3661 kvslfqqilv vqalrpdrlq samalfackt lglkevsplp lnlkrlyket leiepiliii
     3721 spgadpsqel qelanaersg ecyhqvamgq gqadlaiqml kecarngdwl clknlhlvvs
     3781 wlpvlekeln tlqpkdtfrl wltaevhpnf tpillqsslk ityesppglk knlmrtyesw
     3841 tpeqiskkdn thrahalfsl awfhaacqer rnyipqgwtk fyefslsdlr agyniidrlf
     3901 dgakdvqwef vhgllenaiy ggridnyfdl rvlqsylkqf fnssvidvfn qrnkksifpy
     3961 svslpqscsi ldyravieki peddkpsffg lpaniarssq rmissqvisq lrilgrsita
     4021 gskfdreiws nelspvlnlw kklnqnsnli hqkvpppndr qgspilsfii leqfnairlv
     4081 qsvhqslaal skvirgttll ssevqklasa llnqkcplaw qskwegpedp lqylrglvar
     4141 alaiqnwvdk aekqallset ldlselfhpd tflnalrqet aravgrsvds lkfvaswkgr
     4201 lqeaklqiki sglllegcsf dgnqlsenql dspsvssvlp cfmgwipqda cgpyspdeci
     4261 slpvytsaer drvvtnidvp cggnqdqwiq cgaalflknq
//
LOCUS       XP_054225916            4237 aa            linear   PRI 05-AUG-2025
DEFINITION  cytoplasmic dynein 2 heavy chain 1 isoform X2 [Homo sapiens].
ACCESSION   XP_054225916
VERSION     XP_054225916.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369941.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4237
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..4237
                     /product="cytoplasmic dynein 2 heavy chain 1 isoform X2"
                     /calculated_mol_wt=484839
     Region          <234..674
                     /region_name="DHC_N1"
                     /note="Dynein heavy chain, N-terminal region 1; pfam08385"
                     /db_xref="CDD:462457"
     Region          1120..1518
                     /region_name="DHC_N2"
                     /note="Dynein heavy chain, N-terminal region 2; pfam08393"
                     /db_xref="CDD:462462"
     Region          <1361..4016
                     /region_name="DYN1"
                     /note="Dynein, heavy chain [Cytoskeleton]; COG5245"
                     /db_xref="CDD:227570"
     Region          1651..1986
                     /region_name="AAA_6"
                     /note="Hydrolytic ATP binding site of dynein motor region;
                     pfam12774"
                     /db_xref="CDD:463697"
     Region          <4051..4234
                     /region_name="Dynein_C"
                     /note="Dynein heavy chain C-terminal domain; pfam18199"
                     /db_xref="CDD:465677"
     CDS             1..4237
                     /gene="DYNC2H1"
                     /gene_synonym="ATD3; DHC1b; DHC2; DNCH2; DYH1B; hdhc11;
                     SRPS2B; SRTD3"
                     /coded_by="XM_054369941.1:150..12863"
                     /db_xref="GeneID:79659"
                     /db_xref="HGNC:HGNC:2962"
                     /db_xref="MIM:603297"
ORIGIN      
        1 mangtadvrk lfiftttqny fglmselwdq pllcnclein nflddgnqml lrvqrsdagi
       61 sfsntiefgd tkdkvlvffk lrpevitden lhdnilvssm lespisslyq avrqvfapml
      121 lkdqewsrnf dpklqnllse leaglgivlr rsdtnltklk fkeddtrgil tpsdefqfwi
      181 eqahrgnkqi skeranyfke lfetiarefy nldslsllev vdlvettqdv vddvwrqteh
      241 dhypesrmlh lldiiggsfg rfvqkklgtl nlwedpyylv keslkagisi ceqwvivcnh
      301 ltgqvwqryv phpwknekyf petldklgkr leevlairti hekflyflpa seekiicltr
      361 vfepftglnp vqynpytepl wkaavsqyek iiapaeqkia gklknyisei qdspqqllqa
      421 flkykelvkr ptiskelmle retllarlvd sikdfrldfe nrcrgipgda sgplsgknls
      481 evvnsivwvr qlelkvddti kiaeallsdl pgfrcfhqsa kdlldqlkly eqeqfddwsr
      541 diqsglsdsr sglcieassr imeldsndgl lkvhysdrlv illrevrqls algfvipaki
      601 qqvaniaqkf ckqaiilkqv ahfynsidqq miqsqrpmml qsalafeqii knskagsggk
      661 sqitwdnpke legyiqklqn aaerlatenr klrkwhttfc ekvvvlmnid llrqqqrwkd
      721 glqelrtgla tveaqgfqas dmhawkqhwn hqlykalehq yqmglealne nlpeinidlt
      781 ykqgrlqfrp pfeeirakyy remkrfigip nqfkgvgeag desifsimid rnasgfltif
      841 skaedlfrrl savlhqhkew ivigqvdmea lvekhlftvh dweknfkalk ikgkeverlp
      901 savkvdclni ncnpvktvid dliqklfdll vlslkksiqa hlheidtfvt eamevltimp
      961 qsveeigdan lqysklqerk peilplfqea edknrllrtv agggletisn lkakwdkfel
     1021 mmeshqlmik dqievmkgnv ksrlqiyyqe lekfkarwdq lkpgddviet gqhntldksa
     1081 klikekkief ddlevtrkkl vddchhfrle epnfslassi skdiescaqi wafyeefqqg
     1141 fqemanedwi tfrtktylfe eflmnwhdrl rkveehsvmt vklqsevdky kivipilkyv
     1201 rgehlspdhw ldlfrllglp rgtslekllf gdllrvadti vakaadlkdl nsraqgevti
     1261 realreldlw gvgavftlid yedsqsrtmk likdwkdivn qvgdnrcllq slkdspyykg
     1321 fedkvsiwer klaeldeylq nlnhiqrkwv ylepifgrga lpkeqtrfnr vdedfrsimt
     1381 dikkdnrvtt ltthagirns lltildqlqr cqrslnefle ekrsafprfy figdddllei
     1441 lgqstnpsvi qshlkklfag insvcfdeks khitamksle gevvpfknkv plsnnvetwl
     1501 ndlalemkkt leqllkecvt tgrssqgavd pslfpsqilc laeqikfted venaikdhsl
     1561 hqietqlvnk leqytnidts sedpgntesg ilelklkali ldiihnidvv kqlnqiqvht
     1621 tedwawkkql rfymksdhtc cvqmvdsefq ytyeyqgnas klvytpltdk cyltltqamk
     1681 mglggnpygp agtgktesvk alggllgrqv lvfncdegid vksmgrifvg lvkcgawgcf
     1741 defnrleesv lsavsmqiqt iqdalknhrt vcellgkeve vnsnsgifit mnpagkgygg
     1801 rqklpdnlkq lfrpvamshp dneliaevil ysegfkdakv lsrklvaifn lsrelltpqq
     1861 hydwglralk tvlrgsgnll rqlnksgttq naneshivvq alrlntmskf tftdctrfda
     1921 likdvfpgie lkeveydels aalkqvfeea nyeiipnqik kalelyeqlc qrmgvvivgp
     1981 sgagkstlwr mlraalcktg kvvkqytmnp kampryqllg hidmdtrews dgvltnsarq
     2041 vvrepqdvss wiicdgdidp ewieslnsvl ddnrlltmps geriqfgpnv nfvfethdls
     2101 caspatisrm gmiflsdeet dlnslikswl rnqpaeyrnn lenwigdyfe kalqwvlkqn
     2161 dyvvetslvg tvmnglshlh gcrdhdefii nlirglggnl nmksrleftk evfhwaresp
     2221 pdfhkpmdty ydstrgrlat yvlkkpedlt addfsngltl pviqtpdmqr gldyfkpwls
     2281 sdtkqpfilv gpegcgkgml lryafsqlrs tqiatvhcsa qttsrhllqk lsqtcmvist
     2341 ntgrvyrpkd cerlvlylkd inlpkldkwg tstlvaflqq vltyqgfyde nlewvgleni
     2401 qivasmsagg rlgrhklttr ftsivrlcsi dypereqlqt iygaylepvl hknlknhsiw
     2461 gssskiylla gsmvqvyeqv rakftvddys hyfftpcilt qwvlglfryd leggssnhpl
     2521 dyvleivaye arrlfrdkiv gakelhlfdi iltsvfqgdw gsdildnmsd sfyvtwgarh
     2581 nsgaraapgq plpphgkplg klnstdlkdv ikkglihygr dnqnldillf hevleymsri
     2641 drvlsfpggs lllagrsgvg rrtitslvsh mhgavlfspk isrgyelkqf kndlkhvlql
     2701 agieaqqvvl lledyqfvhp tfleminsll ssgevpglyt leeleplllp lkdqasqdgf
     2761 fgpvfnyfty riqqnlhivl imdsansnfm incesnpalh kkcqvlwmeg wsnssmkkip
     2821 emlfsetggg ekyndkkrke ekkknsvdpd flksfllihe sckaygatps qymtflhvys
     2881 aissskkkel lkrqshlqag vsklneakal vdelnrkage qsvllktkqd eadaalqmit
     2941 vsmqdaseqk telerlkhri aeevvkieer knkiddelke vqplvneakl avgnikpesl
     3001 seirslrmpp dvirdilegv lrlmgifdts wvsmksflak rgvrediatf darniskeir
     3061 esveellfkn kgsfdpknak rastaaapla awvkaniqys hvlerihple teqaglesnl
     3121 kktedrkrkl eellnsvgqk vselkekfqs rtseaaklea evskaqetik aaevlinqld
     3181 rehkrwnaqv veiteelatl pkraqlaaaf itylsaapes lrktcleewt ksaglekfdl
     3241 rrflcteseq liwkseglps ddlsienalv ilqsrvcpfl idpssqatew lkthlkdsrl
     3301 evinqqdsnf italelavrf gktliiqemd gvepvlypll rrdlvaqgpr yvvqigdkii
     3361 dyneefrlfl strnpnpfip pdaasivtev nftttrsglr gqllaltiqh ekpdleeqkt
     3421 kllqqeedkk iqlakleesl letlatsqgn ilenkdlies lnqtkassal iqeslkesyk
     3481 lqisldqerd aylplaesas kmyfiisdls kinnmyrfsl aaflrlfqra lqnkqdsent
     3541 eqriqsliss lqhmvyeyic rclfkadqlm falhfvrgmh pelfqenewd tftgvvvgdm
     3601 lrkadsqqki rdqlpswidq erswavatlk ialpslyqtl cfedaalwrt yynnsmceqe
     3661 fpsilakkvs lfqqilvvqa lrpdrlqsam alfacktlgl kevsplplnl krlyketlei
     3721 epiliiispg adpsqelqel anaersgecy hqvamgqgqa dlaiqmlkec arngdwlclk
     3781 nlhlvvswlp vlekelntlq pkdtfrlwlt aevhpnftpi llqsslkity esppglkknl
     3841 mrtyeswtpe qiskkdnthr ahalfslawf haacqerrny ipqgwtkfye fslsdlragy
     3901 niidrlfdga kdvqwefvhg llenaiyggr idnyfdlrvl qsylkqffns svidvfnqrn
     3961 kksifpysvs lpqscsildy raviekiped dkpsffglpa niarssqrmi ssqvisqlri
     4021 lgrsitagsk fdreiwsnel spvlnlwkkl nqcplawqsk wegpedplqy lrglvarala
     4081 iqnwvdkaek qallsetldl selfhpdtfl nalrqetara vgrsvdslkf vaswkgrlqe
     4141 aklqikisgl llegcsfdgn qlsenqldsp svssvlpcfm gwipqdacgp yspdecislp
     4201 vytsaerdrv vtnidvpcgg nqdqwiqcga alflknq
//
LOCUS       XP_054225917            4101 aa            linear   PRI 05-AUG-2025
DEFINITION  cytoplasmic dynein 2 heavy chain 1 isoform X3 [Homo sapiens].
ACCESSION   XP_054225917
VERSION     XP_054225917.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369942.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4101
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..4101
                     /product="cytoplasmic dynein 2 heavy chain 1 isoform X3"
                     /calculated_mol_wt=468676
     Region          <28..468
                     /region_name="DHC_N1"
                     /note="Dynein heavy chain, N-terminal region 1; pfam08385"
                     /db_xref="CDD:462457"
     Region          914..1312
                     /region_name="DHC_N2"
                     /note="Dynein heavy chain, N-terminal region 2; pfam08393"
                     /db_xref="CDD:462462"
     Region          <1155..3810
                     /region_name="DYN1"
                     /note="Dynein, heavy chain [Cytoskeleton]; COG5245"
                     /db_xref="CDD:227570"
     Region          1445..1780
                     /region_name="AAA_6"
                     /note="Hydrolytic ATP binding site of dynein motor region;
                     pfam12774"
                     /db_xref="CDD:463697"
     Region          3805..4098
                     /region_name="Dynein_C"
                     /note="Dynein heavy chain C-terminal domain; pfam18199"
                     /db_xref="CDD:465677"
     CDS             1..4101
                     /gene="DYNC2H1"
                     /gene_synonym="ATD3; DHC1b; DHC2; DNCH2; DYH1B; hdhc11;
                     SRPS2B; SRTD3"
                     /coded_by="XM_054369942.1:17..12322"
                     /db_xref="GeneID:79659"
                     /db_xref="HGNC:HGNC:2962"
                     /db_xref="MIM:603297"
ORIGIN      
        1 mefynldsls llevvdlvet tqdvvddvwr qtehdhypes rmlhlldiig gsfgrfvqkk
       61 lgtlnlwedp yylvkeslka gisiceqwvi vcnhltgqvw qryvphpwkn ekyfpetldk
      121 lgkrleevla irtihekfly flpaseekii cltrvfepft glnpvqynpy teplwkaavs
      181 qyekiiapae qkiagklkny iseiqdspqq llqaflkyke lvkrptiske lmleretlla
      241 rlvdsikdfr ldfenrcrgi pgdasgplsg knlsevvnsi vwvrqlelkv ddtikiaeal
      301 lsdlpgfrcf hqsakdlldq lklyeqeqfd dwsrdiqsgl sdsrsglcie assrimelds
      361 ndgllkvhys drlvillrev rqlsalgfvi pakiqqvani aqkfckqaii lkqvahfyns
      421 idqqmiqsqr pmmlqsalaf eqiiknskag sggksqitwd npkelegyiq klqnaaerla
      481 tenrklrkwh ttfcekvvvl mnidllrqqq rwkdglqelr tglatveaqg fqasdmhawk
      541 qhwnhqlyka lehqyqmgle alnenlpein idltykqgrl qfrppfeeir akyyremkrf
      601 igipnqfkgv geagdesifs imidrnasgf ltifskaedl frrlsavlhq hkewivigqv
      661 dmealvekhl ftvhdweknf kalkikgkev erlpsavkvd clnincnpvk tviddliqkl
      721 fdllvlslkk siqahlheid tfvteamevl timpqsveei gdanlqyskl qerkpeilpl
      781 fqeaedknrl lrtvagggle tisnlkakwd kfelmmeshq lmikdqievm kgnvksrlqi
      841 yyqelekfka rwdqlkpgdd vietgqhntl dksaklikek kiefddlevt rkklvddchh
      901 frleepnfsl assiskdies caqiwafyee fqqgfqeman edwitfrtkt ylfeeflmnw
      961 hdrlrkveeh svmtvklqse vdkykivipi lkyvrgehls pdhwldlfrl lglprgtsle
     1021 kllfgdllrv adtivakaad lkdlnsraqg evtirealre ldlwgvgavf tlidyedsqs
     1081 rtmklikdwk divnqvgdnr cllqslkdsp yykgfedkvs iwerklaeld eylqnlnhiq
     1141 rkwvylepif grgalpkeqt rfnrvdedfr simtdikkdn rvttltthag irnslltild
     1201 qlqrcqrsln efleekrsaf prfyfigddd lleilgqstn psviqshlkk lfaginsvcf
     1261 dekskhitam kslegevvpf knkvplsnnv etwlndlale mkktleqllk ecvttgrssq
     1321 gavdpslfps qilclaeqik ftedvenaik dhslhqietq lvnkleqytn idtssedpgn
     1381 tesgilelkl kalildiihn idvvkqlnqi qvhttedwaw kkqlrfymks dhtccvqmvd
     1441 sefqytyeyq gnasklvytp ltdkcyltlt qamkmglggn pygpagtgkt esvkalggll
     1501 grqvlvfncd egidvksmgr ifvglvkcga wgcfdefnrl eesvlsavsm qiqtiqdalk
     1561 nhrtvcellg kevevnsnsg ifitmnpagk gyggrqklpd nlkqlfrpva mshpdnelia
     1621 evilysegfk dakvlsrklv aifnlsrell tpqqhydwgl ralktvlrgs gnllrqlnks
     1681 gttqnanesh ivvqalrlnt mskftftdct rfdalikdvf pgielkevey delsaalkqv
     1741 feeanyeiip nqikkalely eqlcqrmgvv ivgpsgagks tlwrmlraal cktgkvvkqy
     1801 tmnpkampry qllghidmdt rewsdgvltn sarqvvrepq dvsswiicdg didpewiesl
     1861 nsvlddnrll tmpsgeriqf gpnvnfvfet hdlscaspat isrmgmifls deetdlnsli
     1921 kswlrnqpae yrnnlenwig dyfekalqwv lkqndyvvet slvgtvmngl shlhgcrdhd
     1981 efiinlirgl ggnlnmksrl eftkevfhwa resppdfhkp mdtyydstrg rlatyvlkkp
     2041 edltaddfsn gltlpviqtp dmqrgldyfk pwlssdtkqp filvgpegcg kgmllryafs
     2101 qlrstqiatv hcsaqttsrh llqklsqtcm vistntgrvy rpkdcerlvl ylkdinlpkl
     2161 dkwgtstlva flqqvltyqg fydenlewvg leniqivasm saggrlgrhk lttrftsivr
     2221 lcsidypere qlqtiygayl epvlhknlkn hsiwgssski yllagsmvqv yeqvrakftv
     2281 ddyshyfftp ciltqwvlgl frydleggss nhpldyvlei vayearrlfr dkivgakelh
     2341 lfdiiltsvf qgdwgsdild nmsdsfyvtw garhnsgara apgqplpphg kplgklnstd
     2401 lkdvikkgli hygrdnqnld illfhevley msridrvlsf pggslllagr sgvgrrtits
     2461 lvshmhgavl fspkisrgye lkqfkndlkh vlqlagieaq qvvllledyq fvhptflemi
     2521 nsllssgevp glytleelep lllplkdqas qdgffgpvfn yftyriqqnl hivlimdsan
     2581 snfmincesn palhkkcqvl wmegwsnssm kkipemlfse tgggekyndk krkeekkkns
     2641 vdpdflksfl lihesckayg atpsqymtfl hvysaisssk kkellkrqsh lqagvsklne
     2701 akalvdelnr kageqsvllk tkqdeadaal qmitvsmqda seqktelerl khriaeevvk
     2761 ieerknkidd elkevqplvn eaklavgnik peslseirsl rmppdvirdi legvlrlmgi
     2821 fdtswvsmks flakrgvred iatfdarnis keiresveel lfknkgsfdp knakrastaa
     2881 aplaawvkan iqyshvleri hpleteqagl esnlkktedr krkleellns vgqkvselke
     2941 kfqsrtseaa kleaevskaq etikaaevli nqldrehkrw naqvveitee latlpkraql
     3001 aaafitylsa apeslrktcl eewtksagle kfdlrrflct eseqliwkse glpsddlsie
     3061 nalvilqsrv cpflidpssq atewlkthlk dsrlevinqq dsnfitalel avrfgktlii
     3121 qemdgvepvl ypllrrdlva qgpryvvqig dkiidyneef rlflstrnpn pfippdaasi
     3181 vtevnftttr sglrgqllal tiqhekpdle eqktkllqqe edkkiqlakl eeslletlat
     3241 sqgnilenkd lieslnqtka ssaliqeslk esyklqisld qerdaylpla esaskmyfii
     3301 sdlskinnmy rfslaaflrl fqralqnkqd senteqriqs lisslqhmvy eyicrclfka
     3361 dqlmfalhfv rgmhpelfqe newdtftgvv vgdmlrkads qqkirdqlps widqerswav
     3421 atlkialpsl yqtlcfedaa lwrtyynnsm ceqefpsila kkvslfqqil vvqalrpdrl
     3481 qsamalfack tlglkevspl plnlkrlyke tleiepilii ispgadpsqe lqelanaers
     3541 gecyhqvamg qgqadlaiqm lkecarngdw lclknlhlvv swlpvlekel ntlqpkdtfr
     3601 lwltaevhpn ftpillqssl kityesppgl kknlmrtyes wtpeqiskkd nthrahalfs
     3661 lawfhaacqe rrnyipqgwt kfyefslsdl ragyniidrl fdgakdvqwe fvhgllenai
     3721 yggridnyfd lrvlqsylkq ffnssvidvf nqrnkksifp ysvslpqscs ildyraviek
     3781 ipeddkpsff glpaniarss qrmissqvis qlrilgrsit agskfdreiw snelspvlnl
     3841 wkklnqnsnl ihqkvpppnd rqgspilsfi ileqfnairl vqsvhqslaa lskvirgttl
     3901 lssevqklas allnqkcpla wqskwegped plqylrglva ralaiqnwvd kaekqallse
     3961 tldlselfhp dtflnalrqe taravgrsvd slkfvaswkg rlqeaklqik isglllegcs
     4021 fdgnqlsenq ldspsvssvl pcfmgwipqd acgpyspdec islpvytsae rdrvvtnidv
     4081 pcggnqdqwi qcgaalflkn q
//
LOCUS       XP_054225918            2485 aa            linear   PRI 05-AUG-2025
DEFINITION  cytoplasmic dynein 2 heavy chain 1 isoform X4 [Homo sapiens].
ACCESSION   XP_054225918
VERSION     XP_054225918.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369943.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2485
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2485
                     /product="cytoplasmic dynein 2 heavy chain 1 isoform X4"
                     /calculated_mol_wt=285499
     Region          <234..674
                     /region_name="DHC_N1"
                     /note="Dynein heavy chain, N-terminal region 1; pfam08385"
                     /db_xref="CDD:462457"
     Region          1120..1518
                     /region_name="DHC_N2"
                     /note="Dynein heavy chain, N-terminal region 2; pfam08393"
                     /db_xref="CDD:462462"
     Region          <1361..>2447
                     /region_name="DYN1"
                     /note="Dynein, heavy chain [Cytoskeleton]; COG5245"
                     /db_xref="CDD:227570"
     Region          1651..1986
                     /region_name="AAA_6"
                     /note="Hydrolytic ATP binding site of dynein motor region;
                     pfam12774"
                     /db_xref="CDD:463697"
     CDS             1..2485
                     /gene="DYNC2H1"
                     /gene_synonym="ATD3; DHC1b; DHC2; DNCH2; DYH1B; hdhc11;
                     SRPS2B; SRTD3"
                     /coded_by="XM_054369943.1:150..7607"
                     /db_xref="GeneID:79659"
                     /db_xref="HGNC:HGNC:2962"
                     /db_xref="MIM:603297"
ORIGIN      
        1 mangtadvrk lfiftttqny fglmselwdq pllcnclein nflddgnqml lrvqrsdagi
       61 sfsntiefgd tkdkvlvffk lrpevitden lhdnilvssm lespisslyq avrqvfapml
      121 lkdqewsrnf dpklqnllse leaglgivlr rsdtnltklk fkeddtrgil tpsdefqfwi
      181 eqahrgnkqi skeranyfke lfetiarefy nldslsllev vdlvettqdv vddvwrqteh
      241 dhypesrmlh lldiiggsfg rfvqkklgtl nlwedpyylv keslkagisi ceqwvivcnh
      301 ltgqvwqryv phpwknekyf petldklgkr leevlairti hekflyflpa seekiicltr
      361 vfepftglnp vqynpytepl wkaavsqyek iiapaeqkia gklknyisei qdspqqllqa
      421 flkykelvkr ptiskelmle retllarlvd sikdfrldfe nrcrgipgda sgplsgknls
      481 evvnsivwvr qlelkvddti kiaeallsdl pgfrcfhqsa kdlldqlkly eqeqfddwsr
      541 diqsglsdsr sglcieassr imeldsndgl lkvhysdrlv illrevrqls algfvipaki
      601 qqvaniaqkf ckqaiilkqv ahfynsidqq miqsqrpmml qsalafeqii knskagsggk
      661 sqitwdnpke legyiqklqn aaerlatenr klrkwhttfc ekvvvlmnid llrqqqrwkd
      721 glqelrtgla tveaqgfqas dmhawkqhwn hqlykalehq yqmglealne nlpeinidlt
      781 ykqgrlqfrp pfeeirakyy remkrfigip nqfkgvgeag desifsimid rnasgfltif
      841 skaedlfrrl savlhqhkew ivigqvdmea lvekhlftvh dweknfkalk ikgkeverlp
      901 savkvdclni ncnpvktvid dliqklfdll vlslkksiqa hlheidtfvt eamevltimp
      961 qsveeigdan lqysklqerk peilplfqea edknrllrtv agggletisn lkakwdkfel
     1021 mmeshqlmik dqievmkgnv ksrlqiyyqe lekfkarwdq lkpgddviet gqhntldksa
     1081 klikekkief ddlevtrkkl vddchhfrle epnfslassi skdiescaqi wafyeefqqg
     1141 fqemanedwi tfrtktylfe eflmnwhdrl rkveehsvmt vklqsevdky kivipilkyv
     1201 rgehlspdhw ldlfrllglp rgtslekllf gdllrvadti vakaadlkdl nsraqgevti
     1261 realreldlw gvgavftlid yedsqsrtmk likdwkdivn qvgdnrcllq slkdspyykg
     1321 fedkvsiwer klaeldeylq nlnhiqrkwv ylepifgrga lpkeqtrfnr vdedfrsimt
     1381 dikkdnrvtt ltthagirns lltildqlqr cqrslnefle ekrsafprfy figdddllei
     1441 lgqstnpsvi qshlkklfag insvcfdeks khitamksle gevvpfknkv plsnnvetwl
     1501 ndlalemkkt leqllkecvt tgrssqgavd pslfpsqilc laeqikfted venaikdhsl
     1561 hqietqlvnk leqytnidts sedpgntesg ilelklkali ldiihnidvv kqlnqiqvht
     1621 tedwawkkql rfymksdhtc cvqmvdsefq ytyeyqgnas klvytpltdk cyltltqamk
     1681 mglggnpygp agtgktesvk alggllgrqv lvfncdegid vksmgrifvg lvkcgawgcf
     1741 defnrleesv lsavsmqiqt iqdalknhrt vcellgkeve vnsnsgifit mnpagkgygg
     1801 rqklpdnlkq lfrpvamshp dneliaevil ysegfkdakv lsrklvaifn lsrelltpqq
     1861 hydwglralk tvlrgsgnll rqlnksgttq naneshivvq alrlntmskf tftdctrfda
     1921 likdvfpgie lkeveydels aalkqvfeea nyeiipnqik kalelyeqlc qrmgvvivgp
     1981 sgagkstlwr mlraalcktg kvvkqytmnp kampryqllg hidmdtrews dgvltnsarq
     2041 vvrepqdvss wiicdgdidp ewieslnsvl ddnrlltmps geriqfgpnv nfvfethdls
     2101 caspatisrm gmiflsdeet dlnslikswl rnqpaeyrnn lenwigdyfe kalqwvlkqn
     2161 dyvvetslvg tvmnglshlh gcrdhdefii nlirglggnl nmksrleftk evfhwaresp
     2221 pdfhkpmdty ydstrgrlat yvlkkpedlt addfsngltl pviqtpdmqr gldyfkpwls
     2281 sdtkqpfilv gpegcgkgml lryafsqlrs tqiatvhcsa qttsrhllqk lsqtcmvist
     2341 ntgrvyrpkd cerlvlylkd inlpkldkwg tstlvaflqq vltyqgfyde nlewvgleni
     2401 qivasmsagg rlgrhklttr ftsivrlcsi dypereqlqt iygaylepvl hknlknhsiw
     2461 gssskiylla gsmvqvyeqd pqtih
//
LOCUS       XP_054225919             975 aa            linear   PRI 05-AUG-2025
DEFINITION  NLR family member X1 isoform X1 [Homo sapiens].
ACCESSION   XP_054225919
VERSION     XP_054225919.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369944.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..975
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..975
                     /product="NLR family member X1 isoform X1"
                     /calculated_mol_wt=107485
     Region          5..952
                     /region_name="NACHT"
                     /note="Predicted NTPase, NACHT family domain [Signal
                     transduction mechanisms]; COG5635"
                     /db_xref="CDD:444362"
     Region          160..320
                     /region_name="P-loop containing Nucleoside Triphosphate
                     Hydrolases"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; cl38936"
                     /db_xref="CDD:476819"
     Region          <692..886
                     /region_name="RNA1"
                     /note="Ran GTPase-activating protein (RanGAP) involved in
                     mRNA processing and transport [Translation, ribosomal
                     structure and biogenesis]; COG5238"
                     /db_xref="CDD:444072"
     Region          698..726
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          745..772
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          773..808
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          809..836
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          865..886
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     CDS             1..975
                     /gene="NLRX1"
                     /gene_synonym="CLR11.3; DLNB26; NOD26; NOD5; NOD9"
                     /coded_by="XM_054369944.1:483..3410"
                     /db_xref="GeneID:79671"
                     /db_xref="HGNC:HGNC:29890"
                     /db_xref="MIM:611947"
ORIGIN      
        1 mrwghhlpra swgsgfrral qrpddripfl ihwswplqge rpfgpprafi rhhgssvdsa
       61 pppgrhgrlf psasateaiq rhrrnlaewf srlpreerqf gptfaldtvh vdpvirestp
      121 dellrppael alehqppqag lpplalsqlf npdacgrrvq tvvlygtvgt gkstlvrkmv
      181 ldwcygrlpa fellipfsce dlsslgpapa slcqlvaqry tplkevlplm aaagshllfv
      241 lhglehlnld frlagtglcs dpeepqepaa iivnllrkym lpqasilvtt rpsaigrips
      301 kyvgrygeic gfsdtnlqkl yfqlrlnqpy cgyavggsgv satpaqrdhl vqmlsrnleg
      361 hhqiaaacfl psycwlvcat lhflhaptpa gqtltsiyts flrlnfsget ldstdpsnls
      421 lmayaartmg klayegvssr ktyfseedvc gcleagirte eefqllhifr rdalrfflap
      481 cvepgragtf vftvpamqey laalyivlgl rkttlqkvgk evaelvgrvg edvslvlgim
      541 akllplralp llfnlikvvp rvfgrmvgks reavaqamvl emfreedyyn ddvldqmgas
      601 ilgvegprrh pdeppedevf elfpmfmggl lsahnravla qlgcpiknld alenaqaikk
      661 klgklgrqvl ppselldhlf fhyefqnqrf saevlsslrq lnlagvrmtp vkctvvaavl
      721 gsgrhaldev nlascqldpa glrtllpvfl rarklglqln slgpeackdl rdlllhdqcq
      781 ittlrlsnnp ltaagvavlm eglagntsvt hlsllhtglg deglellaaq ldrnrqlqel
      841 nvayngagdt aalalaraar ehpslellhl yfnelssegr qvlrdlggaa eggarvvvsl
      901 tegtavseyw svilsevqrn lnswdrarvq rhlelllrdl edsrgatlnp wrkaqllrve
      961 gevralleql gssgs
//
LOCUS       XP_054225920             975 aa            linear   PRI 05-AUG-2025
DEFINITION  NLR family member X1 isoform X1 [Homo sapiens].
ACCESSION   XP_054225920
VERSION     XP_054225920.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369945.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..975
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..975
                     /product="NLR family member X1 isoform X1"
                     /calculated_mol_wt=107485
     Region          5..952
                     /region_name="NACHT"
                     /note="Predicted NTPase, NACHT family domain [Signal
                     transduction mechanisms]; COG5635"
                     /db_xref="CDD:444362"
     Region          160..320
                     /region_name="P-loop containing Nucleoside Triphosphate
                     Hydrolases"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; cl38936"
                     /db_xref="CDD:476819"
     Region          <692..886
                     /region_name="RNA1"
                     /note="Ran GTPase-activating protein (RanGAP) involved in
                     mRNA processing and transport [Translation, ribosomal
                     structure and biogenesis]; COG5238"
                     /db_xref="CDD:444072"
     Region          698..726
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          745..772
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          773..808
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          809..836
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          865..886
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     CDS             1..975
                     /gene="NLRX1"
                     /gene_synonym="CLR11.3; DLNB26; NOD26; NOD5; NOD9"
                     /coded_by="XM_054369945.1:147..3074"
                     /db_xref="GeneID:79671"
                     /db_xref="HGNC:HGNC:29890"
                     /db_xref="MIM:611947"
ORIGIN      
        1 mrwghhlpra swgsgfrral qrpddripfl ihwswplqge rpfgpprafi rhhgssvdsa
       61 pppgrhgrlf psasateaiq rhrrnlaewf srlpreerqf gptfaldtvh vdpvirestp
      121 dellrppael alehqppqag lpplalsqlf npdacgrrvq tvvlygtvgt gkstlvrkmv
      181 ldwcygrlpa fellipfsce dlsslgpapa slcqlvaqry tplkevlplm aaagshllfv
      241 lhglehlnld frlagtglcs dpeepqepaa iivnllrkym lpqasilvtt rpsaigrips
      301 kyvgrygeic gfsdtnlqkl yfqlrlnqpy cgyavggsgv satpaqrdhl vqmlsrnleg
      361 hhqiaaacfl psycwlvcat lhflhaptpa gqtltsiyts flrlnfsget ldstdpsnls
      421 lmayaartmg klayegvssr ktyfseedvc gcleagirte eefqllhifr rdalrfflap
      481 cvepgragtf vftvpamqey laalyivlgl rkttlqkvgk evaelvgrvg edvslvlgim
      541 akllplralp llfnlikvvp rvfgrmvgks reavaqamvl emfreedyyn ddvldqmgas
      601 ilgvegprrh pdeppedevf elfpmfmggl lsahnravla qlgcpiknld alenaqaikk
      661 klgklgrqvl ppselldhlf fhyefqnqrf saevlsslrq lnlagvrmtp vkctvvaavl
      721 gsgrhaldev nlascqldpa glrtllpvfl rarklglqln slgpeackdl rdlllhdqcq
      781 ittlrlsnnp ltaagvavlm eglagntsvt hlsllhtglg deglellaaq ldrnrqlqel
      841 nvayngagdt aalalaraar ehpslellhl yfnelssegr qvlrdlggaa eggarvvvsl
      901 tegtavseyw svilsevqrn lnswdrarvq rhlelllrdl edsrgatlnp wrkaqllrve
      961 gevralleql gssgs
//
LOCUS       XP_054225921             921 aa            linear   PRI 05-AUG-2025
DEFINITION  NLR family member X1 isoform X2 [Homo sapiens].
ACCESSION   XP_054225921
VERSION     XP_054225921.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369946.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..921
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..921
                     /product="NLR family member X1 isoform X2"
                     /calculated_mol_wt=101745
     Region          5..872
                     /region_name="NACHT"
                     /note="Predicted NTPase, NACHT family domain [Signal
                     transduction mechanisms]; COG5635"
                     /db_xref="CDD:444362"
     Region          160..320
                     /region_name="P-loop containing Nucleoside Triphosphate
                     Hydrolases"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; cl38936"
                     /db_xref="CDD:476819"
     Region          <698..>850
                     /region_name="PPP1R42"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     cl42388"
                     /db_xref="CDD:455733"
     Region          698..726
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          727..751
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          770..808
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          809..831
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     CDS             1..921
                     /gene="NLRX1"
                     /gene_synonym="CLR11.3; DLNB26; NOD26; NOD5; NOD9"
                     /coded_by="XM_054369946.1:483..3248"
                     /db_xref="GeneID:79671"
                     /db_xref="HGNC:HGNC:29890"
                     /db_xref="MIM:611947"
ORIGIN      
        1 mrwghhlpra swgsgfrral qrpddripfl ihwswplqge rpfgpprafi rhhgssvdsa
       61 pppgrhgrlf psasateaiq rhrrnlaewf srlpreerqf gptfaldtvh vdpvirestp
      121 dellrppael alehqppqag lpplalsqlf npdacgrrvq tvvlygtvgt gkstlvrkmv
      181 ldwcygrlpa fellipfsce dlsslgpapa slcqlvaqry tplkevlplm aaagshllfv
      241 lhglehlnld frlagtglcs dpeepqepaa iivnllrkym lpqasilvtt rpsaigrips
      301 kyvgrygeic gfsdtnlqkl yfqlrlnqpy cgyavggsgv satpaqrdhl vqmlsrnleg
      361 hhqiaaacfl psycwlvcat lhflhaptpa gqtltsiyts flrlnfsget ldstdpsnls
      421 lmayaartmg klayegvssr ktyfseedvc gcleagirte eefqllhifr rdalrfflap
      481 cvepgragtf vftvpamqey laalyivlgl rkttlqkvgk evaelvgrvg edvslvlgim
      541 akllplralp llfnlikvvp rvfgrmvgks reavaqamvl emfreedyyn ddvldqmgas
      601 ilgvegprrh pdeppedevf elfpmfmggl lsahnravla qlgcpiknld alenaqaikk
      661 klgklgrqvl ppselldhlf fhyefqnqrf saevlsslrq lnlagvrmtp vkctvvaavl
      721 gsgrhaldev nlascqldpa glrtllpvfl rarklglqln slgpeackdl rdlllhdqcq
      781 ittlrlsnnp ltaagvavlm eglagntsvt hlsllhtglg deglellaaq ldrnrqlqel
      841 nvayngagdt aalalaraar ehpslellqg vaiqmcwklp llpyahlwtp rmpshwcfll
      901 ilmpplpqwy dglvaprgrc t
//
LOCUS       XP_054225922             921 aa            linear   PRI 05-AUG-2025
DEFINITION  NLR family member X1 isoform X2 [Homo sapiens].
ACCESSION   XP_054225922
VERSION     XP_054225922.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369947.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..921
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..921
                     /product="NLR family member X1 isoform X2"
                     /calculated_mol_wt=101745
     Region          5..872
                     /region_name="NACHT"
                     /note="Predicted NTPase, NACHT family domain [Signal
                     transduction mechanisms]; COG5635"
                     /db_xref="CDD:444362"
     Region          160..320
                     /region_name="P-loop containing Nucleoside Triphosphate
                     Hydrolases"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; cl38936"
                     /db_xref="CDD:476819"
     Region          <698..>850
                     /region_name="PPP1R42"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     cl42388"
                     /db_xref="CDD:455733"
     Region          698..726
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          727..751
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          770..808
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          809..831
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     CDS             1..921
                     /gene="NLRX1"
                     /gene_synonym="CLR11.3; DLNB26; NOD26; NOD5; NOD9"
                     /coded_by="XM_054369947.1:627..3392"
                     /db_xref="GeneID:79671"
                     /db_xref="HGNC:HGNC:29890"
                     /db_xref="MIM:611947"
ORIGIN      
        1 mrwghhlpra swgsgfrral qrpddripfl ihwswplqge rpfgpprafi rhhgssvdsa
       61 pppgrhgrlf psasateaiq rhrrnlaewf srlpreerqf gptfaldtvh vdpvirestp
      121 dellrppael alehqppqag lpplalsqlf npdacgrrvq tvvlygtvgt gkstlvrkmv
      181 ldwcygrlpa fellipfsce dlsslgpapa slcqlvaqry tplkevlplm aaagshllfv
      241 lhglehlnld frlagtglcs dpeepqepaa iivnllrkym lpqasilvtt rpsaigrips
      301 kyvgrygeic gfsdtnlqkl yfqlrlnqpy cgyavggsgv satpaqrdhl vqmlsrnleg
      361 hhqiaaacfl psycwlvcat lhflhaptpa gqtltsiyts flrlnfsget ldstdpsnls
      421 lmayaartmg klayegvssr ktyfseedvc gcleagirte eefqllhifr rdalrfflap
      481 cvepgragtf vftvpamqey laalyivlgl rkttlqkvgk evaelvgrvg edvslvlgim
      541 akllplralp llfnlikvvp rvfgrmvgks reavaqamvl emfreedyyn ddvldqmgas
      601 ilgvegprrh pdeppedevf elfpmfmggl lsahnravla qlgcpiknld alenaqaikk
      661 klgklgrqvl ppselldhlf fhyefqnqrf saevlsslrq lnlagvrmtp vkctvvaavl
      721 gsgrhaldev nlascqldpa glrtllpvfl rarklglqln slgpeackdl rdlllhdqcq
      781 ittlrlsnnp ltaagvavlm eglagntsvt hlsllhtglg deglellaaq ldrnrqlqel
      841 nvayngagdt aalalaraar ehpslellqg vaiqmcwklp llpyahlwtp rmpshwcfll
      901 ilmpplpqwy dglvaprgrc t
//
LOCUS       XP_054225923             921 aa            linear   PRI 05-AUG-2025
DEFINITION  NLR family member X1 isoform X2 [Homo sapiens].
ACCESSION   XP_054225923
VERSION     XP_054225923.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369948.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..921
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..921
                     /product="NLR family member X1 isoform X2"
                     /calculated_mol_wt=101745
     Region          5..872
                     /region_name="NACHT"
                     /note="Predicted NTPase, NACHT family domain [Signal
                     transduction mechanisms]; COG5635"
                     /db_xref="CDD:444362"
     Region          160..320
                     /region_name="P-loop containing Nucleoside Triphosphate
                     Hydrolases"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; cl38936"
                     /db_xref="CDD:476819"
     Region          <698..>850
                     /region_name="PPP1R42"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     cl42388"
                     /db_xref="CDD:455733"
     Region          698..726
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          727..751
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          770..808
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          809..831
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     CDS             1..921
                     /gene="NLRX1"
                     /gene_synonym="CLR11.3; DLNB26; NOD26; NOD5; NOD9"
                     /coded_by="XM_054369948.1:219..2984"
                     /db_xref="GeneID:79671"
                     /db_xref="HGNC:HGNC:29890"
                     /db_xref="MIM:611947"
ORIGIN      
        1 mrwghhlpra swgsgfrral qrpddripfl ihwswplqge rpfgpprafi rhhgssvdsa
       61 pppgrhgrlf psasateaiq rhrrnlaewf srlpreerqf gptfaldtvh vdpvirestp
      121 dellrppael alehqppqag lpplalsqlf npdacgrrvq tvvlygtvgt gkstlvrkmv
      181 ldwcygrlpa fellipfsce dlsslgpapa slcqlvaqry tplkevlplm aaagshllfv
      241 lhglehlnld frlagtglcs dpeepqepaa iivnllrkym lpqasilvtt rpsaigrips
      301 kyvgrygeic gfsdtnlqkl yfqlrlnqpy cgyavggsgv satpaqrdhl vqmlsrnleg
      361 hhqiaaacfl psycwlvcat lhflhaptpa gqtltsiyts flrlnfsget ldstdpsnls
      421 lmayaartmg klayegvssr ktyfseedvc gcleagirte eefqllhifr rdalrfflap
      481 cvepgragtf vftvpamqey laalyivlgl rkttlqkvgk evaelvgrvg edvslvlgim
      541 akllplralp llfnlikvvp rvfgrmvgks reavaqamvl emfreedyyn ddvldqmgas
      601 ilgvegprrh pdeppedevf elfpmfmggl lsahnravla qlgcpiknld alenaqaikk
      661 klgklgrqvl ppselldhlf fhyefqnqrf saevlsslrq lnlagvrmtp vkctvvaavl
      721 gsgrhaldev nlascqldpa glrtllpvfl rarklglqln slgpeackdl rdlllhdqcq
      781 ittlrlsnnp ltaagvavlm eglagntsvt hlsllhtglg deglellaaq ldrnrqlqel
      841 nvayngagdt aalalaraar ehpslellqg vaiqmcwklp llpyahlwtp rmpshwcfll
      901 ilmpplpqwy dglvaprgrc t
//
LOCUS       XP_054225924             797 aa            linear   PRI 05-AUG-2025
DEFINITION  NLR family member X1 isoform X3 [Homo sapiens].
ACCESSION   XP_054225924
VERSION     XP_054225924.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369949.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..797
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..797
                     /product="NLR family member X1 isoform X3"
                     /calculated_mol_wt=87405
     Region          2..142
                     /region_name="P-loop containing Nucleoside Triphosphate
                     Hydrolases"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; cl38936"
                     /db_xref="CDD:476819"
     Region          <8..774
                     /region_name="NACHT"
                     /note="Predicted NTPase, NACHT family domain [Signal
                     transduction mechanisms]; COG5635"
                     /db_xref="CDD:444362"
     Region          <514..708
                     /region_name="RNA1"
                     /note="Ran GTPase-activating protein (RanGAP) involved in
                     mRNA processing and transport [Translation, ribosomal
                     structure and biogenesis]; COG5238"
                     /db_xref="CDD:444072"
     Region          520..548
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          567..594
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          595..630
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          631..658
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          687..708
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     CDS             1..797
                     /gene="NLRX1"
                     /gene_synonym="CLR11.3; DLNB26; NOD26; NOD5; NOD9"
                     /coded_by="XM_054369949.1:484..2877"
                     /db_xref="GeneID:79671"
                     /db_xref="HGNC:HGNC:29890"
                     /db_xref="MIM:611947"
ORIGIN      
        1 mvldwcygrl pafellipfs cedlsslgpa paslcqlvaq rytplkevlp lmaaagshll
       61 fvlhglehln ldfrlagtgl csdpeepqep aaiivnllrk ymlpqasilv ttrpsaigri
      121 pskyvgryge icgfsdtnlq klyfqlrlnq pycgyavggs gvsatpaqrd hlvqmlsrnl
      181 eghhqiaaac flpsycwlvc atlhflhapt pagqtltsiy tsflrlnfsg etldstdpsn
      241 lslmayaart mgklayegvs srktyfseed vcgcleagir teeefqllhi frrdalrffl
      301 apcvepgrag tfvftvpamq eylaalyivl glrkttlqkv gkevaelvgr vgedvslvlg
      361 imakllplra lpllfnlikv vprvfgrmvg ksreavaqam vlemfreedy ynddvldqmg
      421 asilgvegpr rhpdeppede vfelfpmfmg gllsahnrav laqlgcpikn ldalenaqai
      481 kkklgklgrq vlppselldh lffhyefqnq rfsaevlssl rqlnlagvrm tpvkctvvaa
      541 vlgsgrhald evnlascqld paglrtllpv flrarklglq lnslgpeack dlrdlllhdq
      601 cqittlrlsn npltaagvav lmeglagnts vthlsllhtg lgdeglella aqldrnrqlq
      661 elnvayngag dtaalalara arehpslell hlyfnelsse grqvlrdlgg aaeggarvvv
      721 sltegtavse ywsvilsevq rnlnswdrar vqrhlelllr dledsrgatl npwrkaqllr
      781 vegevralle qlgssgs
//
LOCUS       XP_054225925             394 aa            linear   PRI 05-AUG-2025
DEFINITION  asparaginyl-tRNA synthetase isoform X2 [Homo sapiens].
ACCESSION   XP_054225925
VERSION     XP_054225925.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369950.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..394
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..394
                     /product="asparaginyl-tRNA synthetase isoform X2"
                     /calculated_mol_wt=44554
     Region          27..>384
                     /region_name="asnC"
                     /note="asparaginyl-tRNA synthetase; Validated; PRK03932"
                     /db_xref="CDD:235176"
     CDS             1..394
                     /gene="NARS2"
                     /gene_synonym="asnRS; DFNB94; SLM5"
                     /coded_by="XM_054369950.1:377..1561"
                     /db_xref="GeneID:79731"
                     /db_xref="HGNC:HGNC:26274"
                     /db_xref="MIM:612803"
ORIGIN      
        1 mlgvrcllrs vrfcssapfp khkpsaklsv rdalgaqnas gerikiqgwi rsvrsqkevl
       61 flhvndgssl eslqvvadsg ldsreltfgs svevqgqlik spskrqnvel kaekikvign
      121 cdakdfpiky kerhpleylr qyphfrcrtn vlgsilrirs eataaihsff kdsgfvhiht
      181 piitsndseg agelfqleps gklkvpeenf fnvpafltvs gqlhlevmsg aftqvftfgp
      241 tfraensqsr rhlaefymie aeisfvdslq dlmqvieelf kattmmvlsk cpedvelchk
      301 fiapgqkdrl ehmlknnfli isyteaveil kqasqnftft pewgadlrte hekylvkhcg
      361 nipvfvinyp ltlkpfymrd nedgpqhtgc nnwl
//
LOCUS       XP_054225927             394 aa            linear   PRI 05-AUG-2025
DEFINITION  asparaginyl-tRNA synthetase isoform X2 [Homo sapiens].
ACCESSION   XP_054225927
VERSION     XP_054225927.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369952.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..394
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..394
                     /product="asparaginyl-tRNA synthetase isoform X2"
                     /calculated_mol_wt=44554
     Region          27..>384
                     /region_name="asnC"
                     /note="asparaginyl-tRNA synthetase; Validated; PRK03932"
                     /db_xref="CDD:235176"
     CDS             1..394
                     /gene="NARS2"
                     /gene_synonym="asnRS; DFNB94; SLM5"
                     /coded_by="XM_054369952.1:377..1561"
                     /db_xref="GeneID:79731"
                     /db_xref="HGNC:HGNC:26274"
                     /db_xref="MIM:612803"
ORIGIN      
        1 mlgvrcllrs vrfcssapfp khkpsaklsv rdalgaqnas gerikiqgwi rsvrsqkevl
       61 flhvndgssl eslqvvadsg ldsreltfgs svevqgqlik spskrqnvel kaekikvign
      121 cdakdfpiky kerhpleylr qyphfrcrtn vlgsilrirs eataaihsff kdsgfvhiht
      181 piitsndseg agelfqleps gklkvpeenf fnvpafltvs gqlhlevmsg aftqvftfgp
      241 tfraensqsr rhlaefymie aeisfvdslq dlmqvieelf kattmmvlsk cpedvelchk
      301 fiapgqkdrl ehmlknnfli isyteaveil kqasqnftft pewgadlrte hekylvkhcg
      361 nipvfvinyp ltlkpfymrd nedgpqhtgc nnwl
//
LOCUS       XP_054225929             311 aa            linear   PRI 05-AUG-2025
DEFINITION  asparaginyl-tRNA synthetase isoform X4 [Homo sapiens].
ACCESSION   XP_054225929
VERSION     XP_054225929.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369954.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..311
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..311
                     /product="asparaginyl-tRNA synthetase isoform X4"
                     /calculated_mol_wt=34877
     Region          27..>305
                     /region_name="asnC"
                     /note="asparaginyl-tRNA synthetase; Validated; PRK03932"
                     /db_xref="CDD:235176"
     CDS             1..311
                     /gene="NARS2"
                     /gene_synonym="asnRS; DFNB94; SLM5"
                     /coded_by="XM_054369954.1:377..1312"
                     /db_xref="GeneID:79731"
                     /db_xref="HGNC:HGNC:26274"
                     /db_xref="MIM:612803"
ORIGIN      
        1 mlgvrcllrs vrfcssapfp khkpsaklsv rdalgaqnas gerikiqgwi rsvrsqkevl
       61 flhvndgssl eslqvvadsg ldsreltfgs svevqgqlik spskrqnvel kaekikvign
      121 cdakdfpiky kerhpleylr qyphfrcrtn vlgsilrirs eataaihsff kdsgfvhiht
      181 piitsndseg agelfqleps gklkvpeenf fnvpafltvs gqlhlevmsg aftqvftfgp
      241 tfraensqsr rhlaefymie aeisfvdslq dlmqvieelf kattmmvlsk cpedvelchk
      301 fiapgqkhfl y
//
LOCUS       XP_054225930             310 aa            linear   PRI 05-AUG-2025
DEFINITION  asparaginyl-tRNA synthetase isoform X5 [Homo sapiens].
ACCESSION   XP_054225930
VERSION     XP_054225930.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369955.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..310
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..310
                     /product="asparaginyl-tRNA synthetase isoform X5"
                     /calculated_mol_wt=34714
     Region          27..>305
                     /region_name="asnC"
                     /note="asparaginyl-tRNA synthetase; Validated; PRK03932"
                     /db_xref="CDD:235176"
     CDS             1..310
                     /gene="NARS2"
                     /gene_synonym="asnRS; DFNB94; SLM5"
                     /coded_by="XM_054369955.1:377..1309"
                     /db_xref="GeneID:79731"
                     /db_xref="HGNC:HGNC:26274"
                     /db_xref="MIM:612803"
ORIGIN      
        1 mlgvrcllrs vrfcssapfp khkpsaklsv rdalgaqnas gerikiqgwi rsvrsqkevl
       61 flhvndgssl eslqvvadsg ldsreltfgs svevqgqlik spskrqnvel kaekikvign
      121 cdakdfpiky kerhpleylr qyphfrcrtn vlgsilrirs eataaihsff kdsgfvhiht
      181 piitsndseg agelfqleps gklkvpeenf fnvpafltvs gqlhlevmsg aftqvftfgp
      241 tfraensqsr rhlaefymie aeisfvdslq dlmqvieelf kattmmvlsk cpedvelchk
      301 fiapgqksfy
//
LOCUS       XP_054225931             762 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor E2F8 isoform X1 [Homo sapiens].
ACCESSION   XP_054225931
VERSION     XP_054225931.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369956.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..762
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..762
                     /product="transcription factor E2F8 isoform X1"
                     /calculated_mol_wt=81685
     Region          157..242
                     /region_name="E2F_TDP"
                     /note="E2F/DP family winged-helix DNA-binding domain;
                     pfam02319"
                     /db_xref="CDD:460530"
     Region          <359..595
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..762
                     /gene="E2F8"
                     /gene_synonym="E2F-8"
                     /coded_by="XM_054369956.1:508..2796"
                     /db_xref="GeneID:79733"
                     /db_xref="HGNC:HGNC:24727"
                     /db_xref="MIM:612047"
ORIGIN      
        1 menekenlfc ephkrglmkt plkesttani vlaeiqpdfg plttptkpke gsqgepwtpt
       61 anlkmlisav speirnrdqk rglfdnrsgl peakdciheh lsgdefeksq psrkekslgl
      121 lchkflaryp nypnpavnnd icldevaeel tsvnsrkdks lrvmsqkfvm lflvstpqiv
      181 slevaakili gedhvedldk skfktkirrl ydianvlssl dlikkvhvte ergrkpafkw
      241 tgpeispnts gsspvihftp sdlevrrssk encaknlfst rgkpnftrhp sliklvksie
      301 sdrrkinsap sspiktnkae ssqnsapfps kmaqlaaick mqleeqsses rqkvkvqlar
      361 sgpckpvapl dppvnaemel tapsliqplg mvplipspls savplilpqa psgpsyaiyl
      421 qptqahqsvt ppqglsptvc tthsskatgs kdstdattek aandtskasa strpgsllpa
      481 perqgaksrt repagergsk rasmledsgs kkkfkedlkg lenvsatlfp sgylipltqc
      541 sslgaesils gkenssalsp nhriysspia gvipvtssel tavnfpsfhv tplklmvspt
      601 svaavpvgns palasshpvp iqnpssaivn ftlqhlglis pnvqlsaspg sgivpvspri
      661 esvnvapena gtqqgratny dspvpgqsqp ngqsvavtga qqpvpvtpkg sqlvaesffr
      721 tpggptkpts sscmdfegan ktslgtlfvp qrklevsted vh
//
LOCUS       XP_054225932             762 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor E2F8 isoform X1 [Homo sapiens].
ACCESSION   XP_054225932
VERSION     XP_054225932.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369957.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..762
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..762
                     /product="transcription factor E2F8 isoform X1"
                     /calculated_mol_wt=81685
     Region          157..242
                     /region_name="E2F_TDP"
                     /note="E2F/DP family winged-helix DNA-binding domain;
                     pfam02319"
                     /db_xref="CDD:460530"
     Region          <359..595
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..762
                     /gene="E2F8"
                     /gene_synonym="E2F-8"
                     /coded_by="XM_054369957.1:269..2557"
                     /db_xref="GeneID:79733"
                     /db_xref="HGNC:HGNC:24727"
                     /db_xref="MIM:612047"
ORIGIN      
        1 menekenlfc ephkrglmkt plkesttani vlaeiqpdfg plttptkpke gsqgepwtpt
       61 anlkmlisav speirnrdqk rglfdnrsgl peakdciheh lsgdefeksq psrkekslgl
      121 lchkflaryp nypnpavnnd icldevaeel tsvnsrkdks lrvmsqkfvm lflvstpqiv
      181 slevaakili gedhvedldk skfktkirrl ydianvlssl dlikkvhvte ergrkpafkw
      241 tgpeispnts gsspvihftp sdlevrrssk encaknlfst rgkpnftrhp sliklvksie
      301 sdrrkinsap sspiktnkae ssqnsapfps kmaqlaaick mqleeqsses rqkvkvqlar
      361 sgpckpvapl dppvnaemel tapsliqplg mvplipspls savplilpqa psgpsyaiyl
      421 qptqahqsvt ppqglsptvc tthsskatgs kdstdattek aandtskasa strpgsllpa
      481 perqgaksrt repagergsk rasmledsgs kkkfkedlkg lenvsatlfp sgylipltqc
      541 sslgaesils gkenssalsp nhriysspia gvipvtssel tavnfpsfhv tplklmvspt
      601 svaavpvgns palasshpvp iqnpssaivn ftlqhlglis pnvqlsaspg sgivpvspri
      661 esvnvapena gtqqgratny dspvpgqsqp ngqsvavtga qqpvpvtpkg sqlvaesffr
      721 tpggptkpts sscmdfegan ktslgtlfvp qrklevsted vh
//
LOCUS       XP_054225933             762 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor E2F8 isoform X1 [Homo sapiens].
ACCESSION   XP_054225933
VERSION     XP_054225933.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369958.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..762
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..762
                     /product="transcription factor E2F8 isoform X1"
                     /calculated_mol_wt=81685
     Region          157..242
                     /region_name="E2F_TDP"
                     /note="E2F/DP family winged-helix DNA-binding domain;
                     pfam02319"
                     /db_xref="CDD:460530"
     Region          <359..595
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..762
                     /gene="E2F8"
                     /gene_synonym="E2F-8"
                     /coded_by="XM_054369958.1:324..2612"
                     /db_xref="GeneID:79733"
                     /db_xref="HGNC:HGNC:24727"
                     /db_xref="MIM:612047"
ORIGIN      
        1 menekenlfc ephkrglmkt plkesttani vlaeiqpdfg plttptkpke gsqgepwtpt
       61 anlkmlisav speirnrdqk rglfdnrsgl peakdciheh lsgdefeksq psrkekslgl
      121 lchkflaryp nypnpavnnd icldevaeel tsvnsrkdks lrvmsqkfvm lflvstpqiv
      181 slevaakili gedhvedldk skfktkirrl ydianvlssl dlikkvhvte ergrkpafkw
      241 tgpeispnts gsspvihftp sdlevrrssk encaknlfst rgkpnftrhp sliklvksie
      301 sdrrkinsap sspiktnkae ssqnsapfps kmaqlaaick mqleeqsses rqkvkvqlar
      361 sgpckpvapl dppvnaemel tapsliqplg mvplipspls savplilpqa psgpsyaiyl
      421 qptqahqsvt ppqglsptvc tthsskatgs kdstdattek aandtskasa strpgsllpa
      481 perqgaksrt repagergsk rasmledsgs kkkfkedlkg lenvsatlfp sgylipltqc
      541 sslgaesils gkenssalsp nhriysspia gvipvtssel tavnfpsfhv tplklmvspt
      601 svaavpvgns palasshpvp iqnpssaivn ftlqhlglis pnvqlsaspg sgivpvspri
      661 esvnvapena gtqqgratny dspvpgqsqp ngqsvavtga qqpvpvtpkg sqlvaesffr
      721 tpggptkpts sscmdfegan ktslgtlfvp qrklevsted vh
//
LOCUS       XP_054225934             744 aa            linear   PRI 05-AUG-2025
DEFINITION  transcription factor E2F8 isoform X2 [Homo sapiens].
ACCESSION   XP_054225934
VERSION     XP_054225934.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369959.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..744
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..744
                     /product="transcription factor E2F8 isoform X2"
                     /calculated_mol_wt=82007
     Region          114..182
                     /region_name="E2F_TDP"
                     /note="E2F/DP family winged-helix DNA-binding domain;
                     pfam02319"
                     /db_xref="CDD:460530"
     Region          262..347
                     /region_name="E2F_TDP"
                     /note="E2F/DP family winged-helix DNA-binding domain;
                     pfam02319"
                     /db_xref="CDD:460530"
     Region          <464..699
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..744
                     /gene="E2F8"
                     /gene_synonym="E2F-8"
                     /coded_by="XM_054369959.1:508..2742"
                     /db_xref="GeneID:79733"
                     /db_xref="HGNC:HGNC:24727"
                     /db_xref="MIM:612047"
ORIGIN      
        1 menekenlfc ephkrglmkt plkesttani vlaeiqpdfg plttptkpke gsqgepwtpt
       61 anlkmlisav speirnrdqk rglfdnrsgl peakdciheh lsgdefeksq psrkekslgl
      121 lchkflaryp nypnpavnnd icldevaeel nverrriydi vnvleslhmv srlaknrytw
      181 hgrhnlnktl gtlksigeen kyaeqimmik kkeyeqefdf iksysiedhi iksntgpngh
      241 pdmcfvelpg vefraasvns rkdkslrvms qkfvmlflvs tpqivsleva akiligedhv
      301 edldkskfkt kirrlydian vlssldlikk vhvteergrk pafkwtgpei spntsgsspv
      361 ihftpsdlev rrsskencak nlfstrgkpn ftrhpslikl vksiesdrrk insapsspik
      421 tnkaessqns apfpskmaql aaickmqlee qssesrqkvk vqlarsgpck pvapldppvn
      481 aemeltapsl iqplgmvpli psplssavpl ilpqapsgps yaiylqptqa hqsvtppqgl
      541 sptvctthss katgskdstd attekaandt skasastrpg sllpaperqg aksrtrepag
      601 ergskrasml edsgskkkfk edlkglenvs atlfpsgyli pltqcsslga esilsgkens
      661 salspnhriy sspiaanglt nfrgsrtcre qpgsrfkppc shpepklshc klhpaapgth
      721 ltqcavvcqp wvwnrscvsk nrvc
//
LOCUS       XP_054225935             323 aa            linear   PRI 05-AUG-2025
DEFINITION  mitochondrial glutamate carrier 1 isoform X1 [Homo sapiens].
ACCESSION   XP_054225935
VERSION     XP_054225935.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369960.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..323
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..323
                     /product="mitochondrial glutamate carrier 1 isoform X1"
                     /calculated_mol_wt=34339
     Region          3..289
                     /region_name="PTZ00169"
                     /note="ADP/ATP transporter on adenylate translocase;
                     Provisional"
                     /db_xref="CDD:240302"
     Region          4..98
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     CDS             1..323
                     /gene="SLC25A22"
                     /gene_synonym="DEE3; EIEE3; GC-1; GC1; NET44"
                     /coded_by="XM_054369960.1:2208..3179"
                     /db_xref="GeneID:79751"
                     /db_xref="HGNC:HGNC:19954"
                     /db_xref="MIM:609302"
ORIGIN      
        1 madkqislpa klinggiagl igvtcvfpid laktrlqnqq ngqrvytsms dcliktvrse
       61 gyfgmyrgaa vnltlvtpek aiklaandff rhqlskdgqk ltllkemlag cgagtcqviv
      121 ttpmemlkiq lqdagriaaq rkilaaqgql saqggaqpsv eapaaprpta tqltrdllrs
      181 rgiaglykgl gatllrdvpf svvyfplfan lnqlgrpase ekspfyvsfl agcvagsaaa
      241 vavnpcdvvk trlqslqrgv nedtysgild carkilrheg psaflkgayc ralviaplfg
      301 iaqvvyflgi aesllgllqd pqa
//
LOCUS       XP_054225936             323 aa            linear   PRI 05-AUG-2025
DEFINITION  mitochondrial glutamate carrier 1 isoform X1 [Homo sapiens].
ACCESSION   XP_054225936
VERSION     XP_054225936.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369961.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..323
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..323
                     /product="mitochondrial glutamate carrier 1 isoform X1"
                     /calculated_mol_wt=34339
     Region          3..289
                     /region_name="PTZ00169"
                     /note="ADP/ATP transporter on adenylate translocase;
                     Provisional"
                     /db_xref="CDD:240302"
     Region          4..98
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     CDS             1..323
                     /gene="SLC25A22"
                     /gene_synonym="DEE3; EIEE3; GC-1; GC1; NET44"
                     /coded_by="XM_054369961.1:2032..3003"
                     /db_xref="GeneID:79751"
                     /db_xref="HGNC:HGNC:19954"
                     /db_xref="MIM:609302"
ORIGIN      
        1 madkqislpa klinggiagl igvtcvfpid laktrlqnqq ngqrvytsms dcliktvrse
       61 gyfgmyrgaa vnltlvtpek aiklaandff rhqlskdgqk ltllkemlag cgagtcqviv
      121 ttpmemlkiq lqdagriaaq rkilaaqgql saqggaqpsv eapaaprpta tqltrdllrs
      181 rgiaglykgl gatllrdvpf svvyfplfan lnqlgrpase ekspfyvsfl agcvagsaaa
      241 vavnpcdvvk trlqslqrgv nedtysgild carkilrheg psaflkgayc ralviaplfg
      301 iaqvvyflgi aesllgllqd pqa
//
LOCUS       XP_054225937             323 aa            linear   PRI 05-AUG-2025
DEFINITION  mitochondrial glutamate carrier 1 isoform X1 [Homo sapiens].
ACCESSION   XP_054225937
VERSION     XP_054225937.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369962.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..323
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..323
                     /product="mitochondrial glutamate carrier 1 isoform X1"
                     /calculated_mol_wt=34339
     Region          3..289
                     /region_name="PTZ00169"
                     /note="ADP/ATP transporter on adenylate translocase;
                     Provisional"
                     /db_xref="CDD:240302"
     Region          4..98
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     CDS             1..323
                     /gene="SLC25A22"
                     /gene_synonym="DEE3; EIEE3; GC-1; GC1; NET44"
                     /coded_by="XM_054369962.1:738..1709"
                     /db_xref="GeneID:79751"
                     /db_xref="HGNC:HGNC:19954"
                     /db_xref="MIM:609302"
ORIGIN      
        1 madkqislpa klinggiagl igvtcvfpid laktrlqnqq ngqrvytsms dcliktvrse
       61 gyfgmyrgaa vnltlvtpek aiklaandff rhqlskdgqk ltllkemlag cgagtcqviv
      121 ttpmemlkiq lqdagriaaq rkilaaqgql saqggaqpsv eapaaprpta tqltrdllrs
      181 rgiaglykgl gatllrdvpf svvyfplfan lnqlgrpase ekspfyvsfl agcvagsaaa
      241 vavnpcdvvk trlqslqrgv nedtysgild carkilrheg psaflkgayc ralviaplfg
      301 iaqvvyflgi aesllgllqd pqa
//
LOCUS       XP_054225939             323 aa            linear   PRI 05-AUG-2025
DEFINITION  mitochondrial glutamate carrier 1 isoform X1 [Homo sapiens].
ACCESSION   XP_054225939
VERSION     XP_054225939.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369964.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..323
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..323
                     /product="mitochondrial glutamate carrier 1 isoform X1"
                     /calculated_mol_wt=34339
     Region          3..289
                     /region_name="PTZ00169"
                     /note="ADP/ATP transporter on adenylate translocase;
                     Provisional"
                     /db_xref="CDD:240302"
     Region          4..98
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     CDS             1..323
                     /gene="SLC25A22"
                     /gene_synonym="DEE3; EIEE3; GC-1; GC1; NET44"
                     /coded_by="XM_054369964.1:1577..2548"
                     /db_xref="GeneID:79751"
                     /db_xref="HGNC:HGNC:19954"
                     /db_xref="MIM:609302"
ORIGIN      
        1 madkqislpa klinggiagl igvtcvfpid laktrlqnqq ngqrvytsms dcliktvrse
       61 gyfgmyrgaa vnltlvtpek aiklaandff rhqlskdgqk ltllkemlag cgagtcqviv
      121 ttpmemlkiq lqdagriaaq rkilaaqgql saqggaqpsv eapaaprpta tqltrdllrs
      181 rgiaglykgl gatllrdvpf svvyfplfan lnqlgrpase ekspfyvsfl agcvagsaaa
      241 vavnpcdvvk trlqslqrgv nedtysgild carkilrheg psaflkgayc ralviaplfg
      301 iaqvvyflgi aesllgllqd pqa
//
LOCUS       XP_054225941             323 aa            linear   PRI 05-AUG-2025
DEFINITION  mitochondrial glutamate carrier 1 isoform X1 [Homo sapiens].
ACCESSION   XP_054225941
VERSION     XP_054225941.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369966.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..323
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..323
                     /product="mitochondrial glutamate carrier 1 isoform X1"
                     /calculated_mol_wt=34339
     Region          3..289
                     /region_name="PTZ00169"
                     /note="ADP/ATP transporter on adenylate translocase;
                     Provisional"
                     /db_xref="CDD:240302"
     Region          4..98
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     CDS             1..323
                     /gene="SLC25A22"
                     /gene_synonym="DEE3; EIEE3; GC-1; GC1; NET44"
                     /coded_by="XM_054369966.1:283..1254"
                     /db_xref="GeneID:79751"
                     /db_xref="HGNC:HGNC:19954"
                     /db_xref="MIM:609302"
ORIGIN      
        1 madkqislpa klinggiagl igvtcvfpid laktrlqnqq ngqrvytsms dcliktvrse
       61 gyfgmyrgaa vnltlvtpek aiklaandff rhqlskdgqk ltllkemlag cgagtcqviv
      121 ttpmemlkiq lqdagriaaq rkilaaqgql saqggaqpsv eapaaprpta tqltrdllrs
      181 rgiaglykgl gatllrdvpf svvyfplfan lnqlgrpase ekspfyvsfl agcvagsaaa
      241 vavnpcdvvk trlqslqrgv nedtysgild carkilrheg psaflkgayc ralviaplfg
      301 iaqvvyflgi aesllgllqd pqa
//
LOCUS       XP_054225942             323 aa            linear   PRI 05-AUG-2025
DEFINITION  mitochondrial glutamate carrier 1 isoform X1 [Homo sapiens].
ACCESSION   XP_054225942
VERSION     XP_054225942.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369967.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..323
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..323
                     /product="mitochondrial glutamate carrier 1 isoform X1"
                     /calculated_mol_wt=34339
     Region          3..289
                     /region_name="PTZ00169"
                     /note="ADP/ATP transporter on adenylate translocase;
                     Provisional"
                     /db_xref="CDD:240302"
     Region          4..98
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     CDS             1..323
                     /gene="SLC25A22"
                     /gene_synonym="DEE3; EIEE3; GC-1; GC1; NET44"
                     /coded_by="XM_054369967.1:358..1329"
                     /db_xref="GeneID:79751"
                     /db_xref="HGNC:HGNC:19954"
                     /db_xref="MIM:609302"
ORIGIN      
        1 madkqislpa klinggiagl igvtcvfpid laktrlqnqq ngqrvytsms dcliktvrse
       61 gyfgmyrgaa vnltlvtpek aiklaandff rhqlskdgqk ltllkemlag cgagtcqviv
      121 ttpmemlkiq lqdagriaaq rkilaaqgql saqggaqpsv eapaaprpta tqltrdllrs
      181 rgiaglykgl gatllrdvpf svvyfplfan lnqlgrpase ekspfyvsfl agcvagsaaa
      241 vavnpcdvvk trlqslqrgv nedtysgild carkilrheg psaflkgayc ralviaplfg
      301 iaqvvyflgi aesllgllqd pqa
//
LOCUS       XP_054225943             323 aa            linear   PRI 05-AUG-2025
DEFINITION  mitochondrial glutamate carrier 1 isoform X1 [Homo sapiens].
ACCESSION   XP_054225943
VERSION     XP_054225943.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369968.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..323
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..323
                     /product="mitochondrial glutamate carrier 1 isoform X1"
                     /calculated_mol_wt=34339
     Region          3..289
                     /region_name="PTZ00169"
                     /note="ADP/ATP transporter on adenylate translocase;
                     Provisional"
                     /db_xref="CDD:240302"
     Region          4..98
                     /region_name="Mito_carr"
                     /note="Mitochondrial carrier protein; pfam00153"
                     /db_xref="CDD:395101"
     CDS             1..323
                     /gene="SLC25A22"
                     /gene_synonym="DEE3; EIEE3; GC-1; GC1; NET44"
                     /coded_by="XM_054369968.1:243..1214"
                     /db_xref="GeneID:79751"
                     /db_xref="HGNC:HGNC:19954"
                     /db_xref="MIM:609302"
ORIGIN      
        1 madkqislpa klinggiagl igvtcvfpid laktrlqnqq ngqrvytsms dcliktvrse
       61 gyfgmyrgaa vnltlvtpek aiklaandff rhqlskdgqk ltllkemlag cgagtcqviv
      121 ttpmemlkiq lqdagriaaq rkilaaqgql saqggaqpsv eapaaprpta tqltrdllrs
      181 rgiaglykgl gatllrdvpf svvyfplfan lnqlgrpase ekspfyvsfl agcvagsaaa
      241 vavnpcdvvk trlqslqrgv nedtysgild carkilrheg psaflkgayc ralviaplfg
      301 iaqvvyflgi aesllgllqd pqa
//
LOCUS       XP_054225944             544 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 82 isoform X1 [Homo sapiens].
ACCESSION   XP_054225944
VERSION     XP_054225944.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369969.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..544
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..544
                     /product="coiled-coil domain-containing protein 82 isoform
                     X1"
                     /calculated_mol_wt=63871
     Region          102..236
                     /region_name="DUF4196"
                     /note="Domain of unknown function (DUF4196); pfam13846"
                     /db_xref="CDD:433523"
     Region          297..449
                     /region_name="DUF4211"
                     /note="Domain of unknown function (DUF4211); pfam13926"
                     /db_xref="CDD:464045"
     CDS             1..544
                     /gene="CCDC82"
                     /gene_synonym="HSPC048"
                     /coded_by="XM_054369969.1:669..2303"
                     /db_xref="GeneID:79780"
                     /db_xref="HGNC:HGNC:26282"
                     /db_xref="MIM:619870"
ORIGIN      
        1 mihvrrhetr rnskshvpeq ksrvdwrrtk rssisqllds deeldseefd sdeeldsdes
       61 fendeeldsn kgpdcnktpg serelnlski qsegndskcl insgngstye eetnkikhrn
      121 idlqdqekhl sqedndlnkq tgqiieddqe khlsqedndl nkqtgqiied dleeedikrg
      181 krkrlssvmc dsdesddsdi lvrkvgvkrp rrvvedegss vemeqktpek tlaaqkrekl
      241 qklkelskqr srqrrssgrd fedsekescp ssdevdeeee ednyesdedg ddyiiddfvv
      301 qdeegdeenk nqqgekltts qlklvkqnsl ysfsdhythf ervvkallin aldesflgtl
      361 ydgtrqksya kdmltslhyl dnrfvqprle slvsrsrwke qykervenys nvsihlknpe
      421 ncscqacglh ryckysvhls gelyntrtmq idnfmshdkq vftvgricas rtriyhklkh
      481 fkfklyqecc tiamteeved eqvketveri frrskengwi kekygqleey lnfadyfqee
      541 kfel
//
LOCUS       XP_054225945             544 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 82 isoform X1 [Homo sapiens].
ACCESSION   XP_054225945
VERSION     XP_054225945.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369970.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..544
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..544
                     /product="coiled-coil domain-containing protein 82 isoform
                     X1"
                     /calculated_mol_wt=63871
     Region          102..236
                     /region_name="DUF4196"
                     /note="Domain of unknown function (DUF4196); pfam13846"
                     /db_xref="CDD:433523"
     Region          297..449
                     /region_name="DUF4211"
                     /note="Domain of unknown function (DUF4211); pfam13926"
                     /db_xref="CDD:464045"
     CDS             1..544
                     /gene="CCDC82"
                     /gene_synonym="HSPC048"
                     /coded_by="XM_054369970.1:1357..2991"
                     /db_xref="GeneID:79780"
                     /db_xref="HGNC:HGNC:26282"
                     /db_xref="MIM:619870"
ORIGIN      
        1 mihvrrhetr rnskshvpeq ksrvdwrrtk rssisqllds deeldseefd sdeeldsdes
       61 fendeeldsn kgpdcnktpg serelnlski qsegndskcl insgngstye eetnkikhrn
      121 idlqdqekhl sqedndlnkq tgqiieddqe khlsqedndl nkqtgqiied dleeedikrg
      181 krkrlssvmc dsdesddsdi lvrkvgvkrp rrvvedegss vemeqktpek tlaaqkrekl
      241 qklkelskqr srqrrssgrd fedsekescp ssdevdeeee ednyesdedg ddyiiddfvv
      301 qdeegdeenk nqqgekltts qlklvkqnsl ysfsdhythf ervvkallin aldesflgtl
      361 ydgtrqksya kdmltslhyl dnrfvqprle slvsrsrwke qykervenys nvsihlknpe
      421 ncscqacglh ryckysvhls gelyntrtmq idnfmshdkq vftvgricas rtriyhklkh
      481 fkfklyqecc tiamteeved eqvketveri frrskengwi kekygqleey lnfadyfqee
      541 kfel
//
LOCUS       XP_054225946             544 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 82 isoform X1 [Homo sapiens].
ACCESSION   XP_054225946
VERSION     XP_054225946.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369971.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..544
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..544
                     /product="coiled-coil domain-containing protein 82 isoform
                     X1"
                     /calculated_mol_wt=63871
     Region          102..236
                     /region_name="DUF4196"
                     /note="Domain of unknown function (DUF4196); pfam13846"
                     /db_xref="CDD:433523"
     Region          297..449
                     /region_name="DUF4211"
                     /note="Domain of unknown function (DUF4211); pfam13926"
                     /db_xref="CDD:464045"
     CDS             1..544
                     /gene="CCDC82"
                     /gene_synonym="HSPC048"
                     /coded_by="XM_054369971.1:3692..5326"
                     /db_xref="GeneID:79780"
                     /db_xref="HGNC:HGNC:26282"
                     /db_xref="MIM:619870"
ORIGIN      
        1 mihvrrhetr rnskshvpeq ksrvdwrrtk rssisqllds deeldseefd sdeeldsdes
       61 fendeeldsn kgpdcnktpg serelnlski qsegndskcl insgngstye eetnkikhrn
      121 idlqdqekhl sqedndlnkq tgqiieddqe khlsqedndl nkqtgqiied dleeedikrg
      181 krkrlssvmc dsdesddsdi lvrkvgvkrp rrvvedegss vemeqktpek tlaaqkrekl
      241 qklkelskqr srqrrssgrd fedsekescp ssdevdeeee ednyesdedg ddyiiddfvv
      301 qdeegdeenk nqqgekltts qlklvkqnsl ysfsdhythf ervvkallin aldesflgtl
      361 ydgtrqksya kdmltslhyl dnrfvqprle slvsrsrwke qykervenys nvsihlknpe
      421 ncscqacglh ryckysvhls gelyntrtmq idnfmshdkq vftvgricas rtriyhklkh
      481 fkfklyqecc tiamteeved eqvketveri frrskengwi kekygqleey lnfadyfqee
      541 kfel
//
LOCUS       XP_054225947             544 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 82 isoform X1 [Homo sapiens].
ACCESSION   XP_054225947
VERSION     XP_054225947.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369972.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..544
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..544
                     /product="coiled-coil domain-containing protein 82 isoform
                     X1"
                     /calculated_mol_wt=63871
     Region          102..236
                     /region_name="DUF4196"
                     /note="Domain of unknown function (DUF4196); pfam13846"
                     /db_xref="CDD:433523"
     Region          297..449
                     /region_name="DUF4211"
                     /note="Domain of unknown function (DUF4211); pfam13926"
                     /db_xref="CDD:464045"
     CDS             1..544
                     /gene="CCDC82"
                     /gene_synonym="HSPC048"
                     /coded_by="XM_054369972.1:2510..4144"
                     /db_xref="GeneID:79780"
                     /db_xref="HGNC:HGNC:26282"
                     /db_xref="MIM:619870"
ORIGIN      
        1 mihvrrhetr rnskshvpeq ksrvdwrrtk rssisqllds deeldseefd sdeeldsdes
       61 fendeeldsn kgpdcnktpg serelnlski qsegndskcl insgngstye eetnkikhrn
      121 idlqdqekhl sqedndlnkq tgqiieddqe khlsqedndl nkqtgqiied dleeedikrg
      181 krkrlssvmc dsdesddsdi lvrkvgvkrp rrvvedegss vemeqktpek tlaaqkrekl
      241 qklkelskqr srqrrssgrd fedsekescp ssdevdeeee ednyesdedg ddyiiddfvv
      301 qdeegdeenk nqqgekltts qlklvkqnsl ysfsdhythf ervvkallin aldesflgtl
      361 ydgtrqksya kdmltslhyl dnrfvqprle slvsrsrwke qykervenys nvsihlknpe
      421 ncscqacglh ryckysvhls gelyntrtmq idnfmshdkq vftvgricas rtriyhklkh
      481 fkfklyqecc tiamteeved eqvketveri frrskengwi kekygqleey lnfadyfqee
      541 kfel
//
LOCUS       XP_054225948             544 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 82 isoform X1 [Homo sapiens].
ACCESSION   XP_054225948
VERSION     XP_054225948.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369973.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..544
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..544
                     /product="coiled-coil domain-containing protein 82 isoform
                     X1"
                     /calculated_mol_wt=63871
     Region          102..236
                     /region_name="DUF4196"
                     /note="Domain of unknown function (DUF4196); pfam13846"
                     /db_xref="CDD:433523"
     Region          297..449
                     /region_name="DUF4211"
                     /note="Domain of unknown function (DUF4211); pfam13926"
                     /db_xref="CDD:464045"
     CDS             1..544
                     /gene="CCDC82"
                     /gene_synonym="HSPC048"
                     /coded_by="XM_054369973.1:292..1926"
                     /db_xref="GeneID:79780"
                     /db_xref="HGNC:HGNC:26282"
                     /db_xref="MIM:619870"
ORIGIN      
        1 mihvrrhetr rnskshvpeq ksrvdwrrtk rssisqllds deeldseefd sdeeldsdes
       61 fendeeldsn kgpdcnktpg serelnlski qsegndskcl insgngstye eetnkikhrn
      121 idlqdqekhl sqedndlnkq tgqiieddqe khlsqedndl nkqtgqiied dleeedikrg
      181 krkrlssvmc dsdesddsdi lvrkvgvkrp rrvvedegss vemeqktpek tlaaqkrekl
      241 qklkelskqr srqrrssgrd fedsekescp ssdevdeeee ednyesdedg ddyiiddfvv
      301 qdeegdeenk nqqgekltts qlklvkqnsl ysfsdhythf ervvkallin aldesflgtl
      361 ydgtrqksya kdmltslhyl dnrfvqprle slvsrsrwke qykervenys nvsihlknpe
      421 ncscqacglh ryckysvhls gelyntrtmq idnfmshdkq vftvgricas rtriyhklkh
      481 fkfklyqecc tiamteeved eqvketveri frrskengwi kekygqleey lnfadyfqee
      541 kfel
//
LOCUS       XP_054225949             544 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 82 isoform X1 [Homo sapiens].
ACCESSION   XP_054225949
VERSION     XP_054225949.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369974.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..544
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..544
                     /product="coiled-coil domain-containing protein 82 isoform
                     X1"
                     /calculated_mol_wt=63871
     Region          102..236
                     /region_name="DUF4196"
                     /note="Domain of unknown function (DUF4196); pfam13846"
                     /db_xref="CDD:433523"
     Region          297..449
                     /region_name="DUF4211"
                     /note="Domain of unknown function (DUF4211); pfam13926"
                     /db_xref="CDD:464045"
     CDS             1..544
                     /gene="CCDC82"
                     /gene_synonym="HSPC048"
                     /coded_by="XM_054369974.1:712..2346"
                     /db_xref="GeneID:79780"
                     /db_xref="HGNC:HGNC:26282"
                     /db_xref="MIM:619870"
ORIGIN      
        1 mihvrrhetr rnskshvpeq ksrvdwrrtk rssisqllds deeldseefd sdeeldsdes
       61 fendeeldsn kgpdcnktpg serelnlski qsegndskcl insgngstye eetnkikhrn
      121 idlqdqekhl sqedndlnkq tgqiieddqe khlsqedndl nkqtgqiied dleeedikrg
      181 krkrlssvmc dsdesddsdi lvrkvgvkrp rrvvedegss vemeqktpek tlaaqkrekl
      241 qklkelskqr srqrrssgrd fedsekescp ssdevdeeee ednyesdedg ddyiiddfvv
      301 qdeegdeenk nqqgekltts qlklvkqnsl ysfsdhythf ervvkallin aldesflgtl
      361 ydgtrqksya kdmltslhyl dnrfvqprle slvsrsrwke qykervenys nvsihlknpe
      421 ncscqacglh ryckysvhls gelyntrtmq idnfmshdkq vftvgricas rtriyhklkh
      481 fkfklyqecc tiamteeved eqvketveri frrskengwi kekygqleey lnfadyfqee
      541 kfel
//
LOCUS       XP_054225950             544 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 82 isoform X1 [Homo sapiens].
ACCESSION   XP_054225950
VERSION     XP_054225950.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369975.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..544
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..544
                     /product="coiled-coil domain-containing protein 82 isoform
                     X1"
                     /calculated_mol_wt=63871
     Region          102..236
                     /region_name="DUF4196"
                     /note="Domain of unknown function (DUF4196); pfam13846"
                     /db_xref="CDD:433523"
     Region          297..449
                     /region_name="DUF4211"
                     /note="Domain of unknown function (DUF4211); pfam13926"
                     /db_xref="CDD:464045"
     CDS             1..544
                     /gene="CCDC82"
                     /gene_synonym="HSPC048"
                     /coded_by="XM_054369975.1:168..1802"
                     /db_xref="GeneID:79780"
                     /db_xref="HGNC:HGNC:26282"
                     /db_xref="MIM:619870"
ORIGIN      
        1 mihvrrhetr rnskshvpeq ksrvdwrrtk rssisqllds deeldseefd sdeeldsdes
       61 fendeeldsn kgpdcnktpg serelnlski qsegndskcl insgngstye eetnkikhrn
      121 idlqdqekhl sqedndlnkq tgqiieddqe khlsqedndl nkqtgqiied dleeedikrg
      181 krkrlssvmc dsdesddsdi lvrkvgvkrp rrvvedegss vemeqktpek tlaaqkrekl
      241 qklkelskqr srqrrssgrd fedsekescp ssdevdeeee ednyesdedg ddyiiddfvv
      301 qdeegdeenk nqqgekltts qlklvkqnsl ysfsdhythf ervvkallin aldesflgtl
      361 ydgtrqksya kdmltslhyl dnrfvqprle slvsrsrwke qykervenys nvsihlknpe
      421 ncscqacglh ryckysvhls gelyntrtmq idnfmshdkq vftvgricas rtriyhklkh
      481 fkfklyqecc tiamteeved eqvketveri frrskengwi kekygqleey lnfadyfqee
      541 kfel
//
LOCUS       XP_054225952             537 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 82 isoform X2 [Homo sapiens].
ACCESSION   XP_054225952
VERSION     XP_054225952.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369977.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..537
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..537
                     /product="coiled-coil domain-containing protein 82 isoform
                     X2"
                     /calculated_mol_wt=62762
     Region          102..236
                     /region_name="DUF4196"
                     /note="Domain of unknown function (DUF4196); pfam13846"
                     /db_xref="CDD:433523"
     Region          297..449
                     /region_name="DUF4211"
                     /note="Domain of unknown function (DUF4211); pfam13926"
                     /db_xref="CDD:464045"
     CDS             1..537
                     /gene="CCDC82"
                     /gene_synonym="HSPC048"
                     /coded_by="XM_054369977.1:208..1821"
                     /db_xref="GeneID:79780"
                     /db_xref="HGNC:HGNC:26282"
                     /db_xref="MIM:619870"
ORIGIN      
        1 mihvrrhetr rnskshvpeq ksrvdwrrtk rssisqllds deeldseefd sdeeldsdes
       61 fendeeldsn kgpdcnktpg serelnlski qsegndskcl insgngstye eetnkikhrn
      121 idlqdqekhl sqedndlnkq tgqiieddqe khlsqedndl nkqtgqiied dleeedikrg
      181 krkrlssvmc dsdesddsdi lvrkvgvkrp rrvvedegss vemeqktpek tlaaqkrekl
      241 qklkelskqr srqrrssgrd fedsekescp ssdevdeeee ednyesdedg ddyiiddfvv
      301 qdeegdeenk nqqgekltts qlklvkqnsl ysfsdhythf ervvkallin aldesflgtl
      361 ydgtrqksya kdmltslhyl dnrfvqprle slvsrsrwke qykervenys nvsihlknpe
      421 ncscqacglh ryckysvhls gelyntrtmq idnfmshdkq vftvgricas rtriyhklkh
      481 fkfklyqecc tiamteeved eqvketveri frrskengwi kensscdlrv kkhlvpv
//
LOCUS       XP_054225953             537 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 82 isoform X2 [Homo sapiens].
ACCESSION   XP_054225953
VERSION     XP_054225953.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369978.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..537
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..537
                     /product="coiled-coil domain-containing protein 82 isoform
                     X2"
                     /calculated_mol_wt=62762
     Region          102..236
                     /region_name="DUF4196"
                     /note="Domain of unknown function (DUF4196); pfam13846"
                     /db_xref="CDD:433523"
     Region          297..449
                     /region_name="DUF4211"
                     /note="Domain of unknown function (DUF4211); pfam13926"
                     /db_xref="CDD:464045"
     CDS             1..537
                     /gene="CCDC82"
                     /gene_synonym="HSPC048"
                     /coded_by="XM_054369978.1:628..2241"
                     /db_xref="GeneID:79780"
                     /db_xref="HGNC:HGNC:26282"
                     /db_xref="MIM:619870"
ORIGIN      
        1 mihvrrhetr rnskshvpeq ksrvdwrrtk rssisqllds deeldseefd sdeeldsdes
       61 fendeeldsn kgpdcnktpg serelnlski qsegndskcl insgngstye eetnkikhrn
      121 idlqdqekhl sqedndlnkq tgqiieddqe khlsqedndl nkqtgqiied dleeedikrg
      181 krkrlssvmc dsdesddsdi lvrkvgvkrp rrvvedegss vemeqktpek tlaaqkrekl
      241 qklkelskqr srqrrssgrd fedsekescp ssdevdeeee ednyesdedg ddyiiddfvv
      301 qdeegdeenk nqqgekltts qlklvkqnsl ysfsdhythf ervvkallin aldesflgtl
      361 ydgtrqksya kdmltslhyl dnrfvqprle slvsrsrwke qykervenys nvsihlknpe
      421 ncscqacglh ryckysvhls gelyntrtmq idnfmshdkq vftvgricas rtriyhklkh
      481 fkfklyqecc tiamteeved eqvketveri frrskengwi kensscdlrv kkhlvpv
//
LOCUS       XP_054225954             537 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 82 isoform X2 [Homo sapiens].
ACCESSION   XP_054225954
VERSION     XP_054225954.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369979.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..537
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..537
                     /product="coiled-coil domain-containing protein 82 isoform
                     X2"
                     /calculated_mol_wt=62762
     Region          102..236
                     /region_name="DUF4196"
                     /note="Domain of unknown function (DUF4196); pfam13846"
                     /db_xref="CDD:433523"
     Region          297..449
                     /region_name="DUF4211"
                     /note="Domain of unknown function (DUF4211); pfam13926"
                     /db_xref="CDD:464045"
     CDS             1..537
                     /gene="CCDC82"
                     /gene_synonym="HSPC048"
                     /coded_by="XM_054369979.1:3741..5354"
                     /db_xref="GeneID:79780"
                     /db_xref="HGNC:HGNC:26282"
                     /db_xref="MIM:619870"
ORIGIN      
        1 mihvrrhetr rnskshvpeq ksrvdwrrtk rssisqllds deeldseefd sdeeldsdes
       61 fendeeldsn kgpdcnktpg serelnlski qsegndskcl insgngstye eetnkikhrn
      121 idlqdqekhl sqedndlnkq tgqiieddqe khlsqedndl nkqtgqiied dleeedikrg
      181 krkrlssvmc dsdesddsdi lvrkvgvkrp rrvvedegss vemeqktpek tlaaqkrekl
      241 qklkelskqr srqrrssgrd fedsekescp ssdevdeeee ednyesdedg ddyiiddfvv
      301 qdeegdeenk nqqgekltts qlklvkqnsl ysfsdhythf ervvkallin aldesflgtl
      361 ydgtrqksya kdmltslhyl dnrfvqprle slvsrsrwke qykervenys nvsihlknpe
      421 ncscqacglh ryckysvhls gelyntrtmq idnfmshdkq vftvgricas rtriyhklkh
      481 fkfklyqecc tiamteeved eqvketveri frrskengwi kensscdlrv kkhlvpv
//
LOCUS       XP_054225955             537 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 82 isoform X2 [Homo sapiens].
ACCESSION   XP_054225955
VERSION     XP_054225955.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369980.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..537
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..537
                     /product="coiled-coil domain-containing protein 82 isoform
                     X2"
                     /calculated_mol_wt=62762
     Region          102..236
                     /region_name="DUF4196"
                     /note="Domain of unknown function (DUF4196); pfam13846"
                     /db_xref="CDD:433523"
     Region          297..449
                     /region_name="DUF4211"
                     /note="Domain of unknown function (DUF4211); pfam13926"
                     /db_xref="CDD:464045"
     CDS             1..537
                     /gene="CCDC82"
                     /gene_synonym="HSPC048"
                     /coded_by="XM_054369980.1:84..1697"
                     /db_xref="GeneID:79780"
                     /db_xref="HGNC:HGNC:26282"
                     /db_xref="MIM:619870"
ORIGIN      
        1 mihvrrhetr rnskshvpeq ksrvdwrrtk rssisqllds deeldseefd sdeeldsdes
       61 fendeeldsn kgpdcnktpg serelnlski qsegndskcl insgngstye eetnkikhrn
      121 idlqdqekhl sqedndlnkq tgqiieddqe khlsqedndl nkqtgqiied dleeedikrg
      181 krkrlssvmc dsdesddsdi lvrkvgvkrp rrvvedegss vemeqktpek tlaaqkrekl
      241 qklkelskqr srqrrssgrd fedsekescp ssdevdeeee ednyesdedg ddyiiddfvv
      301 qdeegdeenk nqqgekltts qlklvkqnsl ysfsdhythf ervvkallin aldesflgtl
      361 ydgtrqksya kdmltslhyl dnrfvqprle slvsrsrwke qykervenys nvsihlknpe
      421 ncscqacglh ryckysvhls gelyntrtmq idnfmshdkq vftvgricas rtriyhklkh
      481 fkfklyqecc tiamteeved eqvketveri frrskengwi kensscdlrv kkhlvpv
//
LOCUS       XP_054225960             388 aa            linear   PRI 05-AUG-2025
DEFINITION  alpha-1,2-mannosyltransferase ALG9 isoform X5 [Homo sapiens].
ACCESSION   XP_054225960
VERSION     XP_054225960.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369985.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..388
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..388
                     /product="alpha-1,2-mannosyltransferase ALG9 isoform X5"
                     /calculated_mol_wt=43106
     Region          60..>349
                     /region_name="PMT_2"
                     /note="Dolichyl-phosphate-mannose-protein
                     mannosyltransferase; cl21590"
                     /db_xref="CDD:473917"
     CDS             1..388
                     /gene="ALG9"
                     /gene_synonym="CDG1L; DIBD1; GIKANIS; LOH11CR1J"
                     /coded_by="XM_054369985.1:100..1266"
                     /db_xref="GeneID:79796"
                     /db_xref="HGNC:HGNC:15672"
                     /db_xref="MIM:606941"
ORIGIN      
        1 masrgarqrl kgsgassgdt apaadklrel lgsreaggae hrtelsgnka gqvwapegst
       61 afkcllsarl caallsnisd cdetfnywep thyliygegf qtweyspaya irsyaylllh
      121 awpaafhari lqtnkilvfy flrcllafvs cicelyfyka vckkfglhvs rmmlaflvls
      181 tgmfcsssaf lpssfcmytt liamtgwymd ktsiavlgva agailgwpfs aalglpiafd
      241 llvmkhrwks ffhwslmali lflvpvvvid syyygklvia plnivlynvf tphgpdlygt
      301 epwyfyling flnfnvafal allvlpltsl meyllqrfhe mlplcvstis pgalycdiel
      361 agirnclpvw alvifslcgt vqrisrap
//
LOCUS       XP_054225961             204 aa            linear   PRI 05-AUG-2025
DEFINITION  N-alpha-acetyltransferase 40 isoform X1 [Homo sapiens].
ACCESSION   XP_054225961
VERSION     XP_054225961.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369986.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..204
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..204
                     /product="N-alpha-acetyltransferase 40 isoform X1"
                     /calculated_mol_wt=23407
     Region          47..155
                     /region_name="Acetyltransf_1"
                     /note="Acetyltransferase (GNAT) family; pfam00583"
                     /db_xref="CDD:395465"
     CDS             1..204
                     /gene="NAA40"
                     /gene_synonym="hNatD; NAT11; NatD; PATT1"
                     /coded_by="XM_054369986.1:272..886"
                     /db_xref="GeneID:79829"
                     /db_xref="HGNC:HGNC:25845"
                     /db_xref="MIM:619999"
ORIGIN      
        1 mlgdpleafp vfkkydrngl nvsieckrvs glepatvdwa fdltktnmqt myeqsewgwk
       61 drekreemtd drawyliawe nssvpvafsh frfdvecgde vlycyevqle skvrrkglgk
      121 fliqilqlma nstqmkkvml tvfkhnhgay qffrealqfe iddsspsmsg ccgedcsyei
      181 lsrrtkfgds hhshagghcg gcch
//
LOCUS       XP_054225962             237 aa            linear   PRI 05-AUG-2025
DEFINITION  N-alpha-acetyltransferase 40 isoform X2 [Homo sapiens].
ACCESSION   XP_054225962
VERSION     XP_054225962.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369987.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..237
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..237
                     /product="N-alpha-acetyltransferase 40 isoform X2"
                     /calculated_mol_wt=27044
     Region          80..188
                     /region_name="Acetyltransf_1"
                     /note="Acetyltransferase (GNAT) family; pfam00583"
                     /db_xref="CDD:395465"
     CDS             1..237
                     /gene="NAA40"
                     /gene_synonym="hNatD; NAT11; NatD; PATT1"
                     /coded_by="XM_054369987.1:265..978"
                     /db_xref="GeneID:79829"
                     /db_xref="HGNC:HGNC:25845"
                     /db_xref="MIM:619999"
ORIGIN      
        1 mrsplalsgd aklnspgpfh qslprtcdfr arqmlgdple afpvfkkydr nglnvsieck
       61 rvsglepatv dwafdltktn mqtmyeqsew gwkdrekree mtddrawyli awenssvpva
      121 fshfrfdvec gdevlycyev qleskvrrkg lgkfliqilq lmanstqmkk vmltvfkhnh
      181 gayqffreal qfeiddssps msgccgedcs yeilsrrtkf gdshhshagg hcggcch
//
LOCUS       XP_054225963             207 aa            linear   PRI 05-AUG-2025
DEFINITION  N-alpha-acetyltransferase 40 isoform X3 [Homo sapiens].
ACCESSION   XP_054225963
VERSION     XP_054225963.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369988.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..207
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..207
                     /product="N-alpha-acetyltransferase 40 isoform X3"
                     /calculated_mol_wt=23501
     Region          <117..169
                     /region_name="RimI"
                     /note="Ribosomal protein S18 acetylase RimI and related
                     acetyltransferases [Translation, ribosomal structure and
                     biogenesis]; COG0456"
                     /db_xref="CDD:440224"
     CDS             1..207
                     /gene="NAA40"
                     /gene_synonym="hNatD; NAT11; NatD; PATT1"
                     /coded_by="XM_054369988.1:96..719"
                     /db_xref="GeneID:79829"
                     /db_xref="HGNC:HGNC:25845"
                     /db_xref="MIM:619999"
ORIGIN      
        1 mgrksskake kkqkrleera amdavcakvd aanrlgdple afpvfkkydr nglnvsieck
       61 rvsglepatv dwafdltktn mqtmyeqsew gwkdrekree mtddracyev qleskvrrkg
      121 lgkfliqilq lmanstqmkk vmltvfkhnh gayqffreal qfeiddssps msgccgedcs
      181 yeilsrrtkf gdshhshagg hcggcch
//
LOCUS       XP_054225964            1915 aa            linear   PRI 05-AUG-2025
DEFINITION  glutamine and serine-rich protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_054225964
VERSION     XP_054225964.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369989.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1915
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1915
                     /product="glutamine and serine-rich protein 1 isoform X1"
                     /calculated_mol_wt=208932
     Region          166..>516
                     /region_name="Atrophin-1"
                     /note="Atrophin-1 family; pfam03154"
                     /db_xref="CDD:460830"
     Region          <1560..1620
                     /region_name="PHA02939"
                     /note="hypothetical protein; Provisional"
                     /db_xref="CDD:222947"
     Region          1702..1826
                     /region_name="DUF4211"
                     /note="Domain of unknown function (DUF4211); pfam13926"
                     /db_xref="CDD:464045"
     CDS             1..1915
                     /gene="QSER1"
                     /coded_by="XM_054369989.1:322..6069"
                     /db_xref="GeneID:79832"
                     /db_xref="HGNC:HGNC:26154"
                     /db_xref="MIM:619440"
ORIGIN      
        1 mdrnyatsgf tepppppppa ppaapvpasa aaqppapawa yepraaaaaa ssscssgscs
       61 sgsspslkas lsyeeghpsh setdllqrqs faashqlpgy aptpqptgls gifdtsvnsa
      121 ssntkessvm nflstaesrt aqaaasgttl lpqfrapswq tgmhssaate lfatgplpst
      181 gtlppslsay qhpttfsnrn fattsplvlq dstfnttsng ilshhdpllq iktsqgtvpt
      241 alaferlgss vlsnsippqs styrsaqesa phllqpqfsl lpsalggsqq tpqaysstlf
      301 tsstasiera llrecsvikh hqrpsgtqsi qaqltgsqhs lhsylsnssv vnfqettrqs
      361 slscspigds tqvsngglqq ktsqvsvela qsyssaipss gyppsttkik scsteqplts
      421 tktpkpqsii ppvqtlsysk plhnqssvis gqaqiystaq lpsllsvsqs qnyglvqphn
      481 vpsivhsqvy rsskveklpp lyktltfsgs sqtitpenqt lnyssnqqev lssvtnenyp
      541 aqtrdlssvs qsqsyssghs qglspvsqtq vsyssqsqvl svvslsesya sgesltltap
      601 slsyssasra qnlpdssptq nyismhssqn vqtqessspq sqkflpavqs ssfassthcq
      661 tlqnnitspd pksyaerkld sdvypsskqe dgfpmqelqv lqpqasless tqrlsdgein
      721 aqestykvsk addrysqsvi rsnsrledqv igvalqaskk eesvvgsvtq lnrqigqvnn
      781 aatldlknst nliqtpqirl ntkdlkqqhp lilkvheskv qeqhdqiina ssqiqipnha
      841 lghghqaslp ntqvlldsac dlqilqqsil qaglgqvkas lqaqrvqspq qivhpflqme
      901 ghviqsngdh sqqqlhpqns evmkmdlses skplqqhltt kghfsetnqh dsknqfvslg
      961 smcfpeavll sdernilsnv ddilaataaa cgvtptdfsk stsnetmqav edgdskshfq
     1021 qsldvrhvts dfnsmtatvg kpqnindtsl ngnqvtvnls pvpalqskmt ldqqhietpg
     1081 qniptkvtsa vvgpshevqe qssgpfkkqs atnleseeds eapvdstlnn nrnqefvsss
     1141 rsisgesats eseftlggdd sgvsmnpars alallamaqs gdavsvkiee enqdlmhfnl
     1201 qkkrakgkgq vkeednsnqk qlkrpaqgkr qnprgtdiyl pytppssesc hdgyqhqekm
     1261 rqkikeveek qpevktgfia sfldflksgp kqqfstlavr mpnrtrrpgt qmvrtfcppp
     1321 lpkpssttpt plvsetggns psdkvdnelk nlehlssfss deddpgysqd ayksvstplt
     1381 tldatsdkkk ktgkvlqfrf iiitffyfss ysphfklfsl kaglqvhfqd kmyrlldlli
     1441 pekealqvat tsptanttgt attssttvga vkqeplhsts yavnilenis ssesskpiel
     1501 dglpsdqfak gqdtvaiegf tdeedtesgg egqyrerdef vvkiedietf kealktgkep
     1561 paiwkvqkal lqkfvpeird gqrefaatns ylgyfgdaks kykriyvkfi enankkeyvr
     1621 vcskkprnkp sqtirtvqak pssssktsdp laskttttka psvkpkvkqp kvkaepppkk
     1681 rkkwkeefss sqsdsspeih tsssddeefe ppapfvtrfl ntramketfk symellvsia
     1741 ldpdtmqale ksndelllph mkkidgmlnd nrkrlllnlh ldqsfknale sfpeltiitr
     1801 dskaksggta iskikmngka ynkktlrtsk tttksaqefa vdpekiqlys lyhslhhyky
     1861 hvylickdei ssvqkknedl gqeeivqlcm knvkwvedlf ekfgellnhv qqkcs
//
LOCUS       XP_054225965            1834 aa            linear   PRI 05-AUG-2025
DEFINITION  glutamine and serine-rich protein 1 isoform X2 [Homo sapiens].
ACCESSION   XP_054225965
VERSION     XP_054225965.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369990.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 1% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1834
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1834
                     /product="glutamine and serine-rich protein 1 isoform X2"
                     /calculated_mol_wt=199884
     Region          65..>462
                     /region_name="Atrophin-1"
                     /note="Atrophin-1 family; pfam03154"
                     /db_xref="CDD:460830"
     Region          <1455..1515
                     /region_name="PHA02939"
                     /note="hypothetical protein; Provisional"
                     /db_xref="CDD:222947"
     Region          1597..1721
                     /region_name="DUF4211"
                     /note="Domain of unknown function (DUF4211); pfam13926"
                     /db_xref="CDD:464045"
     CDS             1..1834
                     /gene="QSER1"
                     /coded_by="XM_054369990.1:322..5826"
                     /db_xref="GeneID:79832"
                     /db_xref="HGNC:HGNC:26154"
                     /db_xref="MIM:619440"
ORIGIN      
        1 mdrnyatsgf tepppppppa ppaapvpasa aaqppapawa yepraaaaaa ssscssgscs
       61 sgsspslkas lsyeeghpsh setdllqrqs faashqlpgy aptpqptgmh ssaatelfat
      121 gplpstgtlp pslsayqhpt tfsnrnfatt splvlqdstf nttsngilsh hdpllqikts
      181 qgtvptalaf erlgssvlsn sippqsstyr saqesaphll qpqfsllpsa lggsqqtpqa
      241 ysstlftsst asierallre csvikhhqrp sgtqsiqaql tgsqhslhsy lsnssvvnfq
      301 ettrqsslsc spigdstqvs ngglqqktsq vsvelaqsys saipssgypp sttkikscst
      361 eqpltstktp kpqsiippvq tlsyskplhn qssvisgqaq iystaqlpsl lsvsqsqnyg
      421 lvqphnvpsi vhsqvyrssk veklpplykt ltfsgssqti tpenqtlnys snqqevlssv
      481 tnenypaqtr dlssvsqsqs yssghsqgls pvsqtqvsys sqsqvlsvvs lsesyasges
      541 ltltapslsy ssasraqnlp dssptqnyis mhssqnvqtq essspqsqkf lpavqsssfa
      601 ssthcqtlqn nitspdpksy aerkldsdvy psskqedgfp mqelqvlqpq aslesstqrl
      661 sdgeinaqes tykvskaddr ysqsvirsns rledqvigva lqaskkeesv vgsvtqlnrq
      721 igqvnnaatl dlknstnliq tpqirlntkd lkqqhplilk vheskvqeqh dqiinassqi
      781 qipnhalghg hqaslpntqv lldsacdlqi lqqsilqagl gqvkaslqaq rvqspqqivh
      841 pflqmeghvi qsngdhsqqq lhpqnsevmk mdlsesskpl qqhlttkghf setnqhdskn
      901 qfvslgsmcf peavllsder nilsnvddil aataaacgvt ptdfskstsn etmqavedgd
      961 skshfqqsld vrhvtsdfns mtatvgkpqn indtslngnq vtvnlspvpa lqskmtldqq
     1021 hietpgqnip tkvtsavvgp shevqeqssg pfkkqsatnl eseedseapv dstlnnnrnq
     1081 efvsssrsis gesatsesef tlggddsgvs mnparsalal lamaqsgdav svkieeenqd
     1141 lmhfnlqkkr akgkgqvkee dnsnqkqlkr paqgkrqnpr gtdiylpytp psseschdgy
     1201 qhqekmrqki keveekqpev ktgfiasfld flksgpkqqf stlavrmpnr trrpgtqmvr
     1261 tfcppplpkp ssttptplvs etggnspsdk vdnelknleh lssfssdedd pgysqdayks
     1321 vstplttlda tsdkkkktea lqvattspta nttgtattss ttvgavkqep lhstsyavni
     1381 lenisssess kpieldglps dqfakgqdtv aiegftdeed tesggegqyr erdefvvkie
     1441 dietfkealk tgkeppaiwk vqkallqkfv peirdgqref aatnsylgyf gdakskykri
     1501 yvkfienank keyvrvcskk prnkpsqtir tvqakpssss ktsdplaskt tttkapsvkp
     1561 kvkqpkvkae pppkkrkkwk eefsssqsds speihtsssd deefeppapf vtrflntram
     1621 ketfksymel lvsialdpdt mqaleksnde lllphmkkid gmlndnrkrl llnlhldqsf
     1681 knalesfpel tiitrdskak sggtaiskik mngkaynkkt lrtsktttks aqefavdpek
     1741 iqlyslyhsl hhykyhvyli ckdevisshl lkknvfqnvk etlaivfwsv lkrvvkymcv
     1801 cilsmysvnn dliycseslc yvlcsdlpep hhll
//
LOCUS       XP_054225966            1397 aa            linear   PRI 05-AUG-2025
DEFINITION  glutamine and serine-rich protein 1 isoform X3 [Homo sapiens].
ACCESSION   XP_054225966
VERSION     XP_054225966.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369991.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 1% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1397
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1397
                     /product="glutamine and serine-rich protein 1 isoform X3"
                     /calculated_mol_wt=150170
     Region          166..>516
                     /region_name="Atrophin-1"
                     /note="Atrophin-1 family; pfam03154"
                     /db_xref="CDD:460830"
     CDS             1..1397
                     /gene="QSER1"
                     /coded_by="XM_054369991.1:322..4515"
                     /db_xref="GeneID:79832"
                     /db_xref="HGNC:HGNC:26154"
                     /db_xref="MIM:619440"
ORIGIN      
        1 mdrnyatsgf tepppppppa ppaapvpasa aaqppapawa yepraaaaaa ssscssgscs
       61 sgsspslkas lsyeeghpsh setdllqrqs faashqlpgy aptpqptgls gifdtsvnsa
      121 ssntkessvm nflstaesrt aqaaasgttl lpqfrapswq tgmhssaate lfatgplpst
      181 gtlppslsay qhpttfsnrn fattsplvlq dstfnttsng ilshhdpllq iktsqgtvpt
      241 alaferlgss vlsnsippqs styrsaqesa phllqpqfsl lpsalggsqq tpqaysstlf
      301 tsstasiera llrecsvikh hqrpsgtqsi qaqltgsqhs lhsylsnssv vnfqettrqs
      361 slscspigds tqvsngglqq ktsqvsvela qsyssaipss gyppsttkik scsteqplts
      421 tktpkpqsii ppvqtlsysk plhnqssvis gqaqiystaq lpsllsvsqs qnyglvqphn
      481 vpsivhsqvy rsskveklpp lyktltfsgs sqtitpenqt lnyssnqqev lssvtnenyp
      541 aqtrdlssvs qsqsyssghs qglspvsqtq vsyssqsqvl svvslsesya sgesltltap
      601 slsyssasra qnlpdssptq nyismhssqn vqtqessspq sqkflpavqs ssfassthcq
      661 tlqnnitspd pksyaerkld sdvypsskqe dgfpmqelqv lqpqasless tqrlsdgein
      721 aqestykvsk addrysqsvi rsnsrledqv igvalqaskk eesvvgsvtq lnrqigqvnn
      781 aatldlknst nliqtpqirl ntkdlkqqhp lilkvheskv qeqhdqiina ssqiqipnha
      841 lghghqaslp ntqvlldsac dlqilqqsil qaglgqvkas lqaqrvqspq qivhpflqme
      901 ghviqsngdh sqqqlhpqns evmkmdlses skplqqhltt kghfsetnqh dsknqfvslg
      961 smcfpeavll sdernilsnv ddilaataaa cgvtptdfsk stsnetmqav edgdskshfq
     1021 qsldvrhvts dfnsmtatvg kpqnindtsl ngnqvtvnls pvpalqskmt ldqqhietpg
     1081 qniptkvtsa vvgpshevqe qssgpfkkqs atnleseeds eapvdstlnn nrnqefvsss
     1141 rsisgesats eseftlggdd sgvsmnpars alallamaqs gdavsvkiee enqdlmhfnl
     1201 qkkrakgkgq vkeednsnqk qlkrpaqgkr qnprgtdiyl pytppssesc hdgyqhqekm
     1261 rqkikeveek qpevktgfia sfldflksgp kqqfstlavr mpnrtrrpgt qmvrtfcppp
     1321 lpkpssttpt plvsetggns psdkvdnelk nlehlssfss deddpgysqd ayksvstplt
     1381 tldatsdkkk ktdclic
//
LOCUS       XP_054225967            1343 aa            linear   PRI 05-AUG-2025
DEFINITION  glutamine and serine-rich protein 1 isoform X4 [Homo sapiens].
ACCESSION   XP_054225967
VERSION     XP_054225967.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369992.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 1% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1343
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1343
                     /product="glutamine and serine-rich protein 1 isoform X4"
                     /calculated_mol_wt=144578
     Region          65..>462
                     /region_name="Atrophin-1"
                     /note="Atrophin-1 family; pfam03154"
                     /db_xref="CDD:460830"
     CDS             1..1343
                     /gene="QSER1"
                     /coded_by="XM_054369992.1:322..4353"
                     /db_xref="GeneID:79832"
                     /db_xref="HGNC:HGNC:26154"
                     /db_xref="MIM:619440"
ORIGIN      
        1 mdrnyatsgf tepppppppa ppaapvpasa aaqppapawa yepraaaaaa ssscssgscs
       61 sgsspslkas lsyeeghpsh setdllqrqs faashqlpgy aptpqptgmh ssaatelfat
      121 gplpstgtlp pslsayqhpt tfsnrnfatt splvlqdstf nttsngilsh hdpllqikts
      181 qgtvptalaf erlgssvlsn sippqsstyr saqesaphll qpqfsllpsa lggsqqtpqa
      241 ysstlftsst asierallre csvikhhqrp sgtqsiqaql tgsqhslhsy lsnssvvnfq
      301 ettrqsslsc spigdstqvs ngglqqktsq vsvelaqsys saipssgypp sttkikscst
      361 eqpltstktp kpqsiippvq tlsyskplhn qssvisgqaq iystaqlpsl lsvsqsqnyg
      421 lvqphnvpsi vhsqvyrssk veklpplykt ltfsgssqti tpenqtlnys snqqevlssv
      481 tnenypaqtr dlssvsqsqs yssghsqgls pvsqtqvsys sqsqvlsvvs lsesyasges
      541 ltltapslsy ssasraqnlp dssptqnyis mhssqnvqtq essspqsqkf lpavqsssfa
      601 ssthcqtlqn nitspdpksy aerkldsdvy psskqedgfp mqelqvlqpq aslesstqrl
      661 sdgeinaqes tykvskaddr ysqsvirsns rledqvigva lqaskkeesv vgsvtqlnrq
      721 igqvnnaatl dlknstnliq tpqirlntkd lkqqhplilk vheskvqeqh dqiinassqi
      781 qipnhalghg hqaslpntqv lldsacdlqi lqqsilqagl gqvkaslqaq rvqspqqivh
      841 pflqmeghvi qsngdhsqqq lhpqnsevmk mdlsesskpl qqhlttkghf setnqhdskn
      901 qfvslgsmcf peavllsder nilsnvddil aataaacgvt ptdfskstsn etmqavedgd
      961 skshfqqsld vrhvtsdfns mtatvgkpqn indtslngnq vtvnlspvpa lqskmtldqq
     1021 hietpgqnip tkvtsavvgp shevqeqssg pfkkqsatnl eseedseapv dstlnnnrnq
     1081 efvsssrsis gesatsesef tlggddsgvs mnparsalal lamaqsgdav svkieeenqd
     1141 lmhfnlqkkr akgkgqvkee dnsnqkqlkr paqgkrqnpr gtdiylpytp psseschdgy
     1201 qhqekmrqki keveekqpev ktgfiasfld flksgpkqqf stlavrmpnr trrpgtqmvr
     1261 tfcppplpkp ssttptplvs etggnspsdk vdnelknleh lssfssdedd pgysqdayks
     1321 vstplttlda tsdkkkktdc lic
//
LOCUS       XP_054225968             571 aa            linear   PRI 05-AUG-2025
DEFINITION  Na(+)/H(+) exchange regulatory cofactor NHE-RF4 isoform X1 [Homo
            sapiens].
ACCESSION   XP_054225968
VERSION     XP_054225968.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369993.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..571
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..571
                     /product="Na(+)/H(+) exchange regulatory cofactor NHE-RF4
                     isoform X1"
                     /calculated_mol_wt=60901
     Region          114..193
                     /region_name="PDZ_NHERF-like"
                     /note="PDZ domains of the Na+/H+ exchange regulatory
                     cofactor (NHERF) family (NHERF1-4), and related domains;
                     cd06768"
                     /db_xref="CDD:467249"
     Site            order(125..131,142,145,174,178,181..182)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467249"
     Region          222..299
                     /region_name="PDZ_NHERF-like"
                     /note="PDZ domains of the Na+/H+ exchange regulatory
                     cofactor (NHERF) family (NHERF1-4), and related domains;
                     cd06768"
                     /db_xref="CDD:467249"
     Site            order(232..236,247,250,279,283,286..287)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467249"
     Region          328..410
                     /region_name="PDZ_NHERF-like"
                     /note="PDZ domains of the Na+/H+ exchange regulatory
                     cofactor (NHERF) family (NHERF1-4), and related domains;
                     cd06768"
                     /db_xref="CDD:467249"
     Site            order(338..344,358,361,390,394,397..398)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467249"
     Region          475..544
                     /region_name="PDZ"
                     /note="Domain present in PSD-95, Dlg, and ZO-1/2;
                     smart00228"
                     /db_xref="CDD:214570"
     CDS             1..571
                     /gene="NHERF4"
                     /gene_synonym="IKEPP; PDZD3; PDZK2"
                     /coded_by="XM_054369993.1:212..1927"
                     /db_xref="GeneID:79849"
                     /db_xref="HGNC:HGNC:19891"
                     /db_xref="MIM:607146"
ORIGIN      
        1 mvtpsppgnh slsleaprlh tasdllgnhs lglplitalv gsrdrrgrvf spvpvplptn
       61 pttqhptrqk lpstlsghrv cqahgepvlg lcpllplfcc pphppdpwsl erprfcllsk
      121 eegksfgfhl qqelgraghv vcrvdpgtsa qrqglqegdr ilavnndvve hedyavvvrr
      181 irassprvll tvlarhahdv araqlgedah lcptlgpgvr prlchivkde ggfgfsvthg
      241 nqgpfwlvls tggaaeragv ppgarllevn gvsvekfthn qltrklwqsg qqvtllvagp
      301 eveeqcrqlg lplaaplaeg walptkprcl hlekgpqgfg fllreekgld grpgqflwev
      361 dpglpakkag mqagdrlvav agesveglgh eetvsriqgq gscvsltvvd peadrffsmv
      421 rlspllflen teapasprgs ssaslveted psledtsvps vplgsrqcfl ypgpggsygf
      481 rlscvasgpr lfisqvtpgg saaraglqvg dvilevngyp vggqndlerl qqlpeaeppl
      541 clklaarslr gleawippga aedwalasdl l
//
LOCUS       XP_054225969             557 aa            linear   PRI 05-AUG-2025
DEFINITION  Na(+)/H(+) exchange regulatory cofactor NHE-RF4 isoform X2 [Homo
            sapiens].
ACCESSION   XP_054225969
VERSION     XP_054225969.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369994.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..557
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..557
                     /product="Na(+)/H(+) exchange regulatory cofactor NHE-RF4
                     isoform X2"
                     /calculated_mol_wt=59232
     Region          114..193
                     /region_name="PDZ_NHERF-like"
                     /note="PDZ domains of the Na+/H+ exchange regulatory
                     cofactor (NHERF) family (NHERF1-4), and related domains;
                     cd06768"
                     /db_xref="CDD:467249"
     Site            order(125..131,142,145,174,178,181..182)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467249"
     Region          222..285
                     /region_name="PDZ_canonical"
                     /note="canonical PDZ domain; cl49608"
                     /db_xref="CDD:483948"
     Region          314..396
                     /region_name="PDZ_NHERF-like"
                     /note="PDZ domains of the Na+/H+ exchange regulatory
                     cofactor (NHERF) family (NHERF1-4), and related domains;
                     cd06768"
                     /db_xref="CDD:467249"
     Site            order(324..330,344,347,376,380,383..384)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467249"
     Region          461..530
                     /region_name="PDZ"
                     /note="Domain present in PSD-95, Dlg, and ZO-1/2;
                     smart00228"
                     /db_xref="CDD:214570"
     CDS             1..557
                     /gene="NHERF4"
                     /gene_synonym="IKEPP; PDZD3; PDZK2"
                     /coded_by="XM_054369994.1:389..2062"
                     /db_xref="GeneID:79849"
                     /db_xref="HGNC:HGNC:19891"
                     /db_xref="MIM:607146"
ORIGIN      
        1 mvtpsppgnh slsleaprlh tasdllgnhs lglplitalv gsrdrrgrvf spvpvplptn
       61 pttqhptrqk lpstlsghrv cqahgepvlg lcpllplfcc pphppdpwsl erprfcllsk
      121 eegksfgfhl qqelgraghv vcrvdpgtsa qrqglqegdr ilavnndvve hedyavvvrr
      181 irassprvll tvlarhahdv araqlgedah lcptlgpgvr prlchivkde ggfgfsvthg
      241 nqgpfwlvls tggaaeragv ppgarllevn glwqsgqqvt llvagpevee qcrqlglpla
      301 aplaegwalp tkprclhlek gpqgfgfllr eekgldgrpg qflwevdpgl pakkagmqag
      361 drlvavages veglgheetv sriqgqgscv sltvvdpead rffsmvrlsp llflenteap
      421 asprgsssas lvetedpsle dtsvpsvplg srqcflypgp ggsygfrlsc vasgprlfis
      481 qvtpggsaar aglqvgdvil evngypvggq ndlerlqqlp eaepplclkl aarslrglea
      541 wippgaaedw alasdll
//
LOCUS       XP_054225970             506 aa            linear   PRI 05-AUG-2025
DEFINITION  Na(+)/H(+) exchange regulatory cofactor NHE-RF4 isoform X3 [Homo
            sapiens].
ACCESSION   XP_054225970
VERSION     XP_054225970.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369995.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..506
                     /product="Na(+)/H(+) exchange regulatory cofactor NHE-RF4
                     isoform X3"
                     /calculated_mol_wt=54185
     Region          49..128
                     /region_name="PDZ_NHERF-like"
                     /note="PDZ domains of the Na+/H+ exchange regulatory
                     cofactor (NHERF) family (NHERF1-4), and related domains;
                     cd06768"
                     /db_xref="CDD:467249"
     Site            order(60..66,77,80,109,113,116..117)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467249"
     Region          157..234
                     /region_name="PDZ_NHERF-like"
                     /note="PDZ domains of the Na+/H+ exchange regulatory
                     cofactor (NHERF) family (NHERF1-4), and related domains;
                     cd06768"
                     /db_xref="CDD:467249"
     Site            order(167..171,182,185,214,218,221..222)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467249"
     Region          263..345
                     /region_name="PDZ_NHERF-like"
                     /note="PDZ domains of the Na+/H+ exchange regulatory
                     cofactor (NHERF) family (NHERF1-4), and related domains;
                     cd06768"
                     /db_xref="CDD:467249"
     Site            order(273..279,293,296,325,329,332..333)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467249"
     Region          410..479
                     /region_name="PDZ"
                     /note="Domain present in PSD-95, Dlg, and ZO-1/2;
                     smart00228"
                     /db_xref="CDD:214570"
     CDS             1..506
                     /gene="NHERF4"
                     /gene_synonym="IKEPP; PDZD3; PDZK2"
                     /coded_by="XM_054369995.1:21..1541"
                     /db_xref="GeneID:79849"
                     /db_xref="HGNC:HGNC:19891"
                     /db_xref="MIM:607146"
ORIGIN      
        1 mekaavdlqd tasltlkfkf npklgidnpv lslaedhdpy dpwslerprf cllskeegks
       61 fgfhlqqelg raghvvcrvd pgtsaqrqgl qegdrilavn ndvvehedya vvvrrirass
      121 prvlltvlar hahdvaraql gedahlcptl gpgvrprlch ivkdeggfgf svthgnqgpf
      181 wlvlstggaa eragvppgar llevngvsve kfthnqltrk lwqsgqqvtl lvagpeveeq
      241 crqlglplaa plaegwalpt kprclhlekg pqgfgfllre ekgldgrpgq flwevdpglp
      301 akkagmqagd rlvavagesv eglgheetvs riqgqgscvs ltvvdpeadr ffsmvrlspl
      361 lflenteapa sprgsssasl vetedpsled tsvpsvplgs rqcflypgpg gsygfrlscv
      421 asgprlfisq vtpggsaara glqvgdvile vngypvggqn dlerlqqlpe aepplclkla
      481 arslrgleaw ippgaaedwa lasdll
//
LOCUS       XP_054225971             492 aa            linear   PRI 05-AUG-2025
DEFINITION  Na(+)/H(+) exchange regulatory cofactor NHE-RF4 isoform X4 [Homo
            sapiens].
ACCESSION   XP_054225971
VERSION     XP_054225971.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369996.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..492
                     /product="Na(+)/H(+) exchange regulatory cofactor NHE-RF4
                     isoform X4"
                     /calculated_mol_wt=52480
     Region          35..114
                     /region_name="PDZ_NHERF-like"
                     /note="PDZ domains of the Na+/H+ exchange regulatory
                     cofactor (NHERF) family (NHERF1-4), and related domains;
                     cd06768"
                     /db_xref="CDD:467249"
     Site            order(46..52,63,66,95,99,102..103)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467249"
     Region          143..220
                     /region_name="PDZ_NHERF-like"
                     /note="PDZ domains of the Na+/H+ exchange regulatory
                     cofactor (NHERF) family (NHERF1-4), and related domains;
                     cd06768"
                     /db_xref="CDD:467249"
     Site            order(153..157,168,171,200,204,207..208)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467249"
     Region          249..331
                     /region_name="PDZ_NHERF-like"
                     /note="PDZ domains of the Na+/H+ exchange regulatory
                     cofactor (NHERF) family (NHERF1-4), and related domains;
                     cd06768"
                     /db_xref="CDD:467249"
     Site            order(259..265,279,282,311,315,318..319)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467249"
     Region          396..465
                     /region_name="PDZ"
                     /note="Domain present in PSD-95, Dlg, and ZO-1/2;
                     smart00228"
                     /db_xref="CDD:214570"
     CDS             1..492
                     /gene="NHERF4"
                     /gene_synonym="IKEPP; PDZD3; PDZK2"
                     /coded_by="XM_054369996.1:389..1867"
                     /db_xref="GeneID:79849"
                     /db_xref="HGNC:HGNC:19891"
                     /db_xref="MIM:607146"
ORIGIN      
        1 mvtpsppgnh slsleaprlh tasdlldpws lerprfclls keegksfgfh lqqelgragh
       61 vvcrvdpgts aqrqglqegd rilavnndvv ehedyavvvr rirassprvl ltvlarhahd
      121 varaqlgeda hlcptlgpgv rprlchivkd eggfgfsvth gnqgpfwlvl stggaaerag
      181 vppgarllev ngvsvekfth nqltrklwqs gqqvtllvag peveeqcrql glplaaplae
      241 gwalptkprc lhlekgpqgf gfllreekgl dgrpgqflwe vdpglpakka gmqagdrlva
      301 vagesveglg heetvsriqg qgscvsltvv dpeadrffsm vrlspllfle nteapasprg
      361 sssaslvete dpsledtsvp svplgsrqcf lypgpggsyg frlscvasgp rlfisqvtpg
      421 gsaaraglqv gdvilevngy pvggqndler lqqlpeaepp lclklaarsl rgleawippg
      481 aaedwalasd ll
//
LOCUS       XP_054225972             380 aa            linear   PRI 05-AUG-2025
DEFINITION  Na(+)/H(+) exchange regulatory cofactor NHE-RF4 isoform X5 [Homo
            sapiens].
ACCESSION   XP_054225972
VERSION     XP_054225972.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369997.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..380
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..380
                     /product="Na(+)/H(+) exchange regulatory cofactor NHE-RF4
                     isoform X5"
                     /calculated_mol_wt=40798
     Region          114..193
                     /region_name="PDZ_NHERF-like"
                     /note="PDZ domains of the Na+/H+ exchange regulatory
                     cofactor (NHERF) family (NHERF1-4), and related domains;
                     cd06768"
                     /db_xref="CDD:467249"
     Site            order(125..131,142,145,174,178,181..182)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467249"
     Region          222..299
                     /region_name="PDZ_NHERF-like"
                     /note="PDZ domains of the Na+/H+ exchange regulatory
                     cofactor (NHERF) family (NHERF1-4), and related domains;
                     cd06768"
                     /db_xref="CDD:467249"
     Site            order(232..236,247,250,279,283,286..287)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467249"
     Region          328..>356
                     /region_name="PDZ_canonical"
                     /note="canonical PDZ domain; cl49608"
                     /db_xref="CDD:483948"
     CDS             1..380
                     /gene="NHERF4"
                     /gene_synonym="IKEPP; PDZD3; PDZK2"
                     /coded_by="XM_054369997.1:389..1531"
                     /db_xref="GeneID:79849"
                     /db_xref="HGNC:HGNC:19891"
                     /db_xref="MIM:607146"
ORIGIN      
        1 mvtpsppgnh slsleaprlh tasdllgnhs lglplitalv gsrdrrgrvf spvpvplptn
       61 pttqhptrqk lpstlsghrv cqahgepvlg lcpllplfcc pphppdpwsl erprfcllsk
      121 eegksfgfhl qqelgraghv vcrvdpgtsa qrqglqegdr ilavnndvve hedyavvvrr
      181 irassprvll tvlarhahdv araqlgedah lcptlgpgvr prlchivkde ggfgfsvthg
      241 nqgpfwlvls tggaaeragv ppgarllevn gvsvekfthn qltrklwqsg qqvtllvagp
      301 eveeqcrqlg lplaaplaeg walptkprcl hlekgpqgfg fllreekgld grpgspvptp
      361 llgehrgsrl apgqqlsltg
//
LOCUS       XP_054225973             363 aa            linear   PRI 05-AUG-2025
DEFINITION  Na(+)/H(+) exchange regulatory cofactor NHE-RF4 isoform X6 [Homo
            sapiens].
ACCESSION   XP_054225973
VERSION     XP_054225973.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369998.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..363
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..363
                     /product="Na(+)/H(+) exchange regulatory cofactor NHE-RF4
                     isoform X6"
                     /calculated_mol_wt=39126
     Region          114..193
                     /region_name="PDZ_NHERF-like"
                     /note="PDZ domains of the Na+/H+ exchange regulatory
                     cofactor (NHERF) family (NHERF1-4), and related domains;
                     cd06768"
                     /db_xref="CDD:467249"
     Site            order(125..131,142,145,174,178,181..182)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467249"
     Region          222..299
                     /region_name="PDZ_NHERF-like"
                     /note="PDZ domains of the Na+/H+ exchange regulatory
                     cofactor (NHERF) family (NHERF1-4), and related domains;
                     cd06768"
                     /db_xref="CDD:467249"
     Site            order(232..236,247,250,279,283,286..287)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467249"
     Region          328..>351
                     /region_name="PDZ_canonical"
                     /note="canonical PDZ domain; cl49608"
                     /db_xref="CDD:483948"
     CDS             1..363
                     /gene="NHERF4"
                     /gene_synonym="IKEPP; PDZD3; PDZK2"
                     /coded_by="XM_054369998.1:389..1480"
                     /db_xref="GeneID:79849"
                     /db_xref="HGNC:HGNC:19891"
                     /db_xref="MIM:607146"
ORIGIN      
        1 mvtpsppgnh slsleaprlh tasdllgnhs lglplitalv gsrdrrgrvf spvpvplptn
       61 pttqhptrqk lpstlsghrv cqahgepvlg lcpllplfcc pphppdpwsl erprfcllsk
      121 eegksfgfhl qqelgraghv vcrvdpgtsa qrqglqegdr ilavnndvve hedyavvvrr
      181 irassprvll tvlarhahdv araqlgedah lcptlgpgvr prlchivkde ggfgfsvthg
      241 nqgpfwlvls tggaaeragv ppgarllevn gvsvekfthn qltrklwqsg qqvtllvagp
      301 eveeqcrqlg lplaaplaeg walptkprcl hlekgpqgfg fllreekgld grpvpwcvhs
      361 glg
//
LOCUS       XP_054225974             288 aa            linear   PRI 05-AUG-2025
DEFINITION  Na(+)/H(+) exchange regulatory cofactor NHE-RF4 isoform X7 [Homo
            sapiens].
ACCESSION   XP_054225974
VERSION     XP_054225974.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054369999.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..288
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..288
                     /product="Na(+)/H(+) exchange regulatory cofactor NHE-RF4
                     isoform X7"
                     /calculated_mol_wt=31052
     Region          114..193
                     /region_name="PDZ_NHERF-like"
                     /note="PDZ domains of the Na+/H+ exchange regulatory
                     cofactor (NHERF) family (NHERF1-4), and related domains;
                     cd06768"
                     /db_xref="CDD:467249"
     Site            order(125..131,142,145,174,178,181..182)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467249"
     Region          222..286
                     /region_name="PDZ_NHERF-like"
                     /note="PDZ domains of the Na+/H+ exchange regulatory
                     cofactor (NHERF) family (NHERF1-4), and related domains;
                     cd06768"
                     /db_xref="CDD:467249"
     CDS             1..288
                     /gene="NHERF4"
                     /gene_synonym="IKEPP; PDZD3; PDZK2"
                     /coded_by="XM_054369999.1:389..1255"
                     /db_xref="GeneID:79849"
                     /db_xref="HGNC:HGNC:19891"
                     /db_xref="MIM:607146"
ORIGIN      
        1 mvtpsppgnh slsleaprlh tasdllgnhs lglplitalv gsrdrrgrvf spvpvplptn
       61 pttqhptrqk lpstlsghrv cqahgepvlg lcpllplfcc pphppdpwsl erprfcllsk
      121 eegksfgfhl qqelgraghv vcrvdpgtsa qrqglqegdr ilavnndvve hedyavvvrr
      181 irassprvll tvlarhahdv araqlgedah lcptlgpgvr prlchivkde ggfgfsvthg
      241 nqgpfwlvls tggaaeragv ppgarllevn gvsvekfthn qltrkvly
//
LOCUS       XP_054225975             514 aa            linear   PRI 05-AUG-2025
DEFINITION  cleavage and polyadenylation specificity factor subunit 7 isoform
            X1 [Homo sapiens].
ACCESSION   XP_054225975
VERSION     XP_054225975.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370000.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 3% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..514
                     /product="cleavage and polyadenylation specificity factor
                     subunit 7 isoform X1"
                     /calculated_mol_wt=56244
     Region          124..213
                     /region_name="RRM_CFIm59"
                     /note="RNA recognition motif (RRM) found in pre-mRNA
                     cleavage factor Im 59 kDa subunit (CFIm59 or CPSF7) and
                     similar proteins; cd12644"
                     /db_xref="CDD:410049"
     Site            order(134..139,155,157..158,160..167)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410049"
     CDS             1..514
                     /gene="CPSF7"
                     /gene_synonym="CFIm59"
                     /coded_by="XM_054370000.1:146..1690"
                     /db_xref="GeneID:79869"
                     /db_xref="HGNC:HGNC:30098"
                     /db_xref="MIM:621247"
ORIGIN      
        1 mgrpesaggg srgpfegggr arraggiflt lsilrtrdlp sgamsegvdl idiyadeefn
       61 qdpefnntdq idlyddvlta tsqpsddrss steppppvrq epspkpnnkt pailytysgl
      121 rnrraavyvg sfswwttdqq liqvirsigv ydvvelkfae nrangqskgy aevvvasens
      181 vhkllellpg kvlngekvdv rpatrqnlsq feaqarkrec vrvprggipp rahsrdssds
      241 adgratpsen lvpssarvdk ppsvlpyfnr ppsalplmgl ppppippppp lsssfgvppp
      301 ppgihyqhlm pppprlpphl avpppgaipp alhlnpaffp ppnatvgppp dtymkasapy
      361 nhhgsrdsgp ppstvseaef edimkrnrai sssaiskavs gasagdysda ietlltaiav
      421 ikqsrvande rcrvlisslk dclhgieaks ysvgasgsss rkrhrsrers psrsressrr
      481 hrdllhnedr hddyfqernr eherhrdrer drhh
//
LOCUS       XP_054225976             505 aa            linear   PRI 05-AUG-2025
DEFINITION  cleavage and polyadenylation specificity factor subunit 7 isoform
            X2 [Homo sapiens].
ACCESSION   XP_054225976
VERSION     XP_054225976.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370001.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..505
                     /product="cleavage and polyadenylation specificity factor
                     subunit 7 isoform X2"
                     /calculated_mol_wt=55290
     Region          124..213
                     /region_name="RRM_CFIm59"
                     /note="RNA recognition motif (RRM) found in pre-mRNA
                     cleavage factor Im 59 kDa subunit (CFIm59 or CPSF7) and
                     similar proteins; cd12644"
                     /db_xref="CDD:410049"
     Site            order(134..139,155,157..158,160..167)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410049"
     CDS             1..505
                     /gene="CPSF7"
                     /gene_synonym="CFIm59"
                     /coded_by="XM_054370001.1:146..1663"
                     /db_xref="GeneID:79869"
                     /db_xref="HGNC:HGNC:30098"
                     /db_xref="MIM:621247"
ORIGIN      
        1 mgrpesaggg srgpfegggr arraggiflt lsilrtrdlp sgamsegvdl idiyadeefn
       61 qdpefnntdq idlyddvlta tsqpsddrss steppppvrq epspkpnnkt pailytysgl
      121 rnrraavyvg sfswwttdqq liqvirsigv ydvvelkfae nrangqskgy aevvvasens
      181 vhkllellpg kvlngekvdv rpatrqnlsq feaqarkrip prahsrdssd sadgratpse
      241 nlvpssarvd kppsvlpyfn rppsalplmg lppppipppp plsssfgvpp pppgihyqhl
      301 mpppprlpph lavpppgaip palhlnpaff pppnatvgpp pdtymkasap ynhhgsrdsg
      361 pppstvseae fedimkrnra isssaiskav sgasagdysd aietlltaia vikqsrvand
      421 ercrvlissl kdclhgieak sysvgasgss srkrhrsrer spsrsressr rhrdllhned
      481 rhddyfqern reherhrdre rdrhh
//
LOCUS       XP_054225977             471 aa            linear   PRI 05-AUG-2025
DEFINITION  cleavage and polyadenylation specificity factor subunit 7 isoform
            X3 [Homo sapiens].
ACCESSION   XP_054225977
VERSION     XP_054225977.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370002.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..471
                     /product="cleavage and polyadenylation specificity factor
                     subunit 7 isoform X3"
                     /calculated_mol_wt=51919
     Region          81..170
                     /region_name="RRM_CFIm59"
                     /note="RNA recognition motif (RRM) found in pre-mRNA
                     cleavage factor Im 59 kDa subunit (CFIm59 or CPSF7) and
                     similar proteins; cd12644"
                     /db_xref="CDD:410049"
     Site            order(91..96,112,114..115,117..124)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410049"
     CDS             1..471
                     /gene="CPSF7"
                     /gene_synonym="CFIm59"
                     /coded_by="XM_054370002.1:165..1580"
                     /db_xref="GeneID:79869"
                     /db_xref="HGNC:HGNC:30098"
                     /db_xref="MIM:621247"
ORIGIN      
        1 msegvdlidi yadeefnqdp efnntdqidl yddvltatsq psddrssste ppppvrqeps
       61 pkpnnktpai lytysglrnr raavyvgsfs wwttdqqliq virsigvydv velkfaenra
      121 ngqskgyaev vvasensvhk llellpgkvl ngekvdvrpa trqnlsqfea qarkrecvrv
      181 prggipprah srdssdsadg ratpsenlvp ssarvdkpps vlpyfnrpps alplmglppp
      241 pippppplss sfgvpppppg ihyqhlmppp prlpphlavp ppgaippalh lnpaffpppn
      301 atvgpppdty mkasapynhh gsrdsgppps tvseaefedi mkrnraisss aiskavsgas
      361 agdysdaiet lltaiavikq srvandercr vlisslkdcl hgieaksysv gasgsssrkr
      421 hrsrerspsr sressrrhrd llhnedrhdd yfqernrehe rhrdrerdrh h
//
LOCUS       XP_054225978             471 aa            linear   PRI 05-AUG-2025
DEFINITION  cleavage and polyadenylation specificity factor subunit 7 isoform
            X3 [Homo sapiens].
ACCESSION   XP_054225978
VERSION     XP_054225978.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370003.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..471
                     /product="cleavage and polyadenylation specificity factor
                     subunit 7 isoform X3"
                     /calculated_mol_wt=51919
     Region          81..170
                     /region_name="RRM_CFIm59"
                     /note="RNA recognition motif (RRM) found in pre-mRNA
                     cleavage factor Im 59 kDa subunit (CFIm59 or CPSF7) and
                     similar proteins; cd12644"
                     /db_xref="CDD:410049"
     Site            order(91..96,112,114..115,117..124)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410049"
     CDS             1..471
                     /gene="CPSF7"
                     /gene_synonym="CFIm59"
                     /coded_by="XM_054370003.1:78..1493"
                     /db_xref="GeneID:79869"
                     /db_xref="HGNC:HGNC:30098"
                     /db_xref="MIM:621247"
ORIGIN      
        1 msegvdlidi yadeefnqdp efnntdqidl yddvltatsq psddrssste ppppvrqeps
       61 pkpnnktpai lytysglrnr raavyvgsfs wwttdqqliq virsigvydv velkfaenra
      121 ngqskgyaev vvasensvhk llellpgkvl ngekvdvrpa trqnlsqfea qarkrecvrv
      181 prggipprah srdssdsadg ratpsenlvp ssarvdkpps vlpyfnrpps alplmglppp
      241 pippppplss sfgvpppppg ihyqhlmppp prlpphlavp ppgaippalh lnpaffpppn
      301 atvgpppdty mkasapynhh gsrdsgppps tvseaefedi mkrnraisss aiskavsgas
      361 agdysdaiet lltaiavikq srvandercr vlisslkdcl hgieaksysv gasgsssrkr
      421 hrsrerspsr sressrrhrd llhnedrhdd yfqernrehe rhrdrerdrh h
//
LOCUS       XP_054225979             462 aa            linear   PRI 05-AUG-2025
DEFINITION  cleavage and polyadenylation specificity factor subunit 7 isoform
            X4 [Homo sapiens].
ACCESSION   XP_054225979
VERSION     XP_054225979.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370004.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..462
                     /product="cleavage and polyadenylation specificity factor
                     subunit 7 isoform X4"
                     /calculated_mol_wt=50965
     Region          81..170
                     /region_name="RRM_CFIm59"
                     /note="RNA recognition motif (RRM) found in pre-mRNA
                     cleavage factor Im 59 kDa subunit (CFIm59 or CPSF7) and
                     similar proteins; cd12644"
                     /db_xref="CDD:410049"
     Site            order(91..96,112,114..115,117..124)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410049"
     CDS             1..462
                     /gene="CPSF7"
                     /gene_synonym="CFIm59"
                     /coded_by="XM_054370004.1:191..1579"
                     /db_xref="GeneID:79869"
                     /db_xref="HGNC:HGNC:30098"
                     /db_xref="MIM:621247"
ORIGIN      
        1 msegvdlidi yadeefnqdp efnntdqidl yddvltatsq psddrssste ppppvrqeps
       61 pkpnnktpai lytysglrnr raavyvgsfs wwttdqqliq virsigvydv velkfaenra
      121 ngqskgyaev vvasensvhk llellpgkvl ngekvdvrpa trqnlsqfea qarkrippra
      181 hsrdssdsad gratpsenlv pssarvdkpp svlpyfnrpp salplmglpp ppipppppls
      241 ssfgvppppp gihyqhlmpp pprlpphlav pppgaippal hlnpaffppp natvgpppdt
      301 ymkasapynh hgsrdsgppp stvseaefed imkrnraiss saiskavsga sagdysdaie
      361 tlltaiavik qsrvanderc rvlisslkdc lhgieaksys vgasgsssrk rhrsrersps
      421 rsressrrhr dllhnedrhd dyfqernreh erhrdrerdr hh
//
LOCUS       XP_054225980             462 aa            linear   PRI 05-AUG-2025
DEFINITION  cleavage and polyadenylation specificity factor subunit 7 isoform
            X4 [Homo sapiens].
ACCESSION   XP_054225980
VERSION     XP_054225980.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370005.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..462
                     /product="cleavage and polyadenylation specificity factor
                     subunit 7 isoform X4"
                     /calculated_mol_wt=50965
     Region          81..170
                     /region_name="RRM_CFIm59"
                     /note="RNA recognition motif (RRM) found in pre-mRNA
                     cleavage factor Im 59 kDa subunit (CFIm59 or CPSF7) and
                     similar proteins; cd12644"
                     /db_xref="CDD:410049"
     Site            order(91..96,112,114..115,117..124)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410049"
     CDS             1..462
                     /gene="CPSF7"
                     /gene_synonym="CFIm59"
                     /coded_by="XM_054370005.1:78..1466"
                     /db_xref="GeneID:79869"
                     /db_xref="HGNC:HGNC:30098"
                     /db_xref="MIM:621247"
ORIGIN      
        1 msegvdlidi yadeefnqdp efnntdqidl yddvltatsq psddrssste ppppvrqeps
       61 pkpnnktpai lytysglrnr raavyvgsfs wwttdqqliq virsigvydv velkfaenra
      121 ngqskgyaev vvasensvhk llellpgkvl ngekvdvrpa trqnlsqfea qarkrippra
      181 hsrdssdsad gratpsenlv pssarvdkpp svlpyfnrpp salplmglpp ppipppppls
      241 ssfgvppppp gihyqhlmpp pprlpphlav pppgaippal hlnpaffppp natvgpppdt
      301 ymkasapynh hgsrdsgppp stvseaefed imkrnraiss saiskavsga sagdysdaie
      361 tlltaiavik qsrvanderc rvlisslkdc lhgieaksys vgasgsssrk rhrsrersps
      421 rsressrrhr dllhnedrhd dyfqernreh erhrdrerdr hh
//
LOCUS       XP_054225981             447 aa            linear   PRI 05-AUG-2025
DEFINITION  cleavage and polyadenylation specificity factor subunit 7 isoform
            X5 [Homo sapiens].
ACCESSION   XP_054225981
VERSION     XP_054225981.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370006.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 3% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..447
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..447
                     /product="cleavage and polyadenylation specificity factor
                     subunit 7 isoform X5"
                     /calculated_mol_wt=49355
     Region          <84..>306
                     /region_name="PHA03377"
                     /note="EBNA-3C; Provisional"
                     /db_xref="CDD:177614"
     Region          124..213
                     /region_name="RRM_CFIm59"
                     /note="RNA recognition motif (RRM) found in pre-mRNA
                     cleavage factor Im 59 kDa subunit (CFIm59 or CPSF7) and
                     similar proteins; cd12644"
                     /db_xref="CDD:410049"
     Site            order(134..139,155,157..158,160..167)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410049"
     CDS             1..447
                     /gene="CPSF7"
                     /gene_synonym="CFIm59"
                     /coded_by="XM_054370006.1:146..1489"
                     /db_xref="GeneID:79869"
                     /db_xref="HGNC:HGNC:30098"
                     /db_xref="MIM:621247"
ORIGIN      
        1 mgrpesaggg srgpfegggr arraggiflt lsilrtrdlp sgamsegvdl idiyadeefn
       61 qdpefnntdq idlyddvlta tsqpsddrss steppppvrq epspkpnnkt pailytysgl
      121 rnrraavyvg sfswwttdqq liqvirsigv ydvvelkfae nrangqskgy aevvvasens
      181 vhkllellpg kvlngekvdv rpatrqnlsq feaqarkrec vrvprggipp rahsrdssds
      241 adgratpsen lvpssarvdk ppsvlpyfnr ppsalplmvg pppdtymkas apynhhgsrd
      301 sgpppstvse aefedimkrn raisssaisk avsgasagdy sdaietllta iavikqsrva
      361 ndercrvlis slkdclhgie aksysvgasg sssrkrhrsr erspsrsres srrhrdllhn
      421 edrhddyfqe rnreherhrd rerdrhh
//
LOCUS       XP_054225982             438 aa            linear   PRI 05-AUG-2025
DEFINITION  cleavage and polyadenylation specificity factor subunit 7 isoform
            X6 [Homo sapiens].
ACCESSION   XP_054225982
VERSION     XP_054225982.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370007.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 4% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..438
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..438
                     /product="cleavage and polyadenylation specificity factor
                     subunit 7 isoform X6"
                     /calculated_mol_wt=48401
     Region          <84..>297
                     /region_name="PHA03377"
                     /note="EBNA-3C; Provisional"
                     /db_xref="CDD:177614"
     Region          124..213
                     /region_name="RRM_CFIm59"
                     /note="RNA recognition motif (RRM) found in pre-mRNA
                     cleavage factor Im 59 kDa subunit (CFIm59 or CPSF7) and
                     similar proteins; cd12644"
                     /db_xref="CDD:410049"
     Site            order(134..139,155,157..158,160..167)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410049"
     CDS             1..438
                     /gene="CPSF7"
                     /gene_synonym="CFIm59"
                     /coded_by="XM_054370007.1:146..1462"
                     /db_xref="GeneID:79869"
                     /db_xref="HGNC:HGNC:30098"
                     /db_xref="MIM:621247"
ORIGIN      
        1 mgrpesaggg srgpfegggr arraggiflt lsilrtrdlp sgamsegvdl idiyadeefn
       61 qdpefnntdq idlyddvlta tsqpsddrss steppppvrq epspkpnnkt pailytysgl
      121 rnrraavyvg sfswwttdqq liqvirsigv ydvvelkfae nrangqskgy aevvvasens
      181 vhkllellpg kvlngekvdv rpatrqnlsq feaqarkrip prahsrdssd sadgratpse
      241 nlvpssarvd kppsvlpyfn rppsalplmv gpppdtymka sapynhhgsr dsgpppstvs
      301 eaefedimkr nraisssais kavsgasagd ysdaietllt aiavikqsrv andercrvli
      361 sslkdclhgi eaksysvgas gsssrkrhrs rerspsrsre ssrrhrdllh nedrhddyfq
      421 ernreherhr drerdrhh
//
LOCUS       XP_054225983             404 aa            linear   PRI 05-AUG-2025
DEFINITION  cleavage and polyadenylation specificity factor subunit 7 isoform
            X7 [Homo sapiens].
ACCESSION   XP_054225983
VERSION     XP_054225983.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370008.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..404
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..404
                     /product="cleavage and polyadenylation specificity factor
                     subunit 7 isoform X7"
                     /calculated_mol_wt=45030
     Region          <41..>263
                     /region_name="PHA03377"
                     /note="EBNA-3C; Provisional"
                     /db_xref="CDD:177614"
     Region          81..170
                     /region_name="RRM_CFIm59"
                     /note="RNA recognition motif (RRM) found in pre-mRNA
                     cleavage factor Im 59 kDa subunit (CFIm59 or CPSF7) and
                     similar proteins; cd12644"
                     /db_xref="CDD:410049"
     Site            order(91..96,112,114..115,117..124)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410049"
     CDS             1..404
                     /gene="CPSF7"
                     /gene_synonym="CFIm59"
                     /coded_by="XM_054370008.1:118..1332"
                     /db_xref="GeneID:79869"
                     /db_xref="HGNC:HGNC:30098"
                     /db_xref="MIM:621247"
ORIGIN      
        1 msegvdlidi yadeefnqdp efnntdqidl yddvltatsq psddrssste ppppvrqeps
       61 pkpnnktpai lytysglrnr raavyvgsfs wwttdqqliq virsigvydv velkfaenra
      121 ngqskgyaev vvasensvhk llellpgkvl ngekvdvrpa trqnlsqfea qarkrecvrv
      181 prggipprah srdssdsadg ratpsenlvp ssarvdkpps vlpyfnrpps alplmvgppp
      241 dtymkasapy nhhgsrdsgp ppstvseaef edimkrnrai sssaiskavs gasagdysda
      301 ietlltaiav ikqsrvande rcrvlisslk dclhgieaks ysvgasgsss rkrhrsrers
      361 psrsressrr hrdllhnedr hddyfqernr eherhrdrer drhh
//
LOCUS       XP_054225984             404 aa            linear   PRI 05-AUG-2025
DEFINITION  cleavage and polyadenylation specificity factor subunit 7 isoform
            X7 [Homo sapiens].
ACCESSION   XP_054225984
VERSION     XP_054225984.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370009.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..404
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..404
                     /product="cleavage and polyadenylation specificity factor
                     subunit 7 isoform X7"
                     /calculated_mol_wt=45030
     Region          <41..>263
                     /region_name="PHA03377"
                     /note="EBNA-3C; Provisional"
                     /db_xref="CDD:177614"
     Region          81..170
                     /region_name="RRM_CFIm59"
                     /note="RNA recognition motif (RRM) found in pre-mRNA
                     cleavage factor Im 59 kDa subunit (CFIm59 or CPSF7) and
                     similar proteins; cd12644"
                     /db_xref="CDD:410049"
     Site            order(91..96,112,114..115,117..124)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410049"
     CDS             1..404
                     /gene="CPSF7"
                     /gene_synonym="CFIm59"
                     /coded_by="XM_054370009.1:132..1346"
                     /db_xref="GeneID:79869"
                     /db_xref="HGNC:HGNC:30098"
                     /db_xref="MIM:621247"
ORIGIN      
        1 msegvdlidi yadeefnqdp efnntdqidl yddvltatsq psddrssste ppppvrqeps
       61 pkpnnktpai lytysglrnr raavyvgsfs wwttdqqliq virsigvydv velkfaenra
      121 ngqskgyaev vvasensvhk llellpgkvl ngekvdvrpa trqnlsqfea qarkrecvrv
      181 prggipprah srdssdsadg ratpsenlvp ssarvdkpps vlpyfnrpps alplmvgppp
      241 dtymkasapy nhhgsrdsgp ppstvseaef edimkrnrai sssaiskavs gasagdysda
      301 ietlltaiav ikqsrvande rcrvlisslk dclhgieaks ysvgasgsss rkrhrsrers
      361 psrsressrr hrdllhnedr hddyfqernr eherhrdrer drhh
//
LOCUS       XP_054225985             395 aa            linear   PRI 05-AUG-2025
DEFINITION  cleavage and polyadenylation specificity factor subunit 7 isoform
            X8 [Homo sapiens].
ACCESSION   XP_054225985
VERSION     XP_054225985.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370010.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..395
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..395
                     /product="cleavage and polyadenylation specificity factor
                     subunit 7 isoform X8"
                     /calculated_mol_wt=44076
     Region          <41..>254
                     /region_name="PHA03377"
                     /note="EBNA-3C; Provisional"
                     /db_xref="CDD:177614"
     Region          81..170
                     /region_name="RRM_CFIm59"
                     /note="RNA recognition motif (RRM) found in pre-mRNA
                     cleavage factor Im 59 kDa subunit (CFIm59 or CPSF7) and
                     similar proteins; cd12644"
                     /db_xref="CDD:410049"
     Site            order(91..96,112,114..115,117..124)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410049"
     CDS             1..395
                     /gene="CPSF7"
                     /gene_synonym="CFIm59"
                     /coded_by="XM_054370010.1:118..1305"
                     /db_xref="GeneID:79869"
                     /db_xref="HGNC:HGNC:30098"
                     /db_xref="MIM:621247"
ORIGIN      
        1 msegvdlidi yadeefnqdp efnntdqidl yddvltatsq psddrssste ppppvrqeps
       61 pkpnnktpai lytysglrnr raavyvgsfs wwttdqqliq virsigvydv velkfaenra
      121 ngqskgyaev vvasensvhk llellpgkvl ngekvdvrpa trqnlsqfea qarkrippra
      181 hsrdssdsad gratpsenlv pssarvdkpp svlpyfnrpp salplmvgpp pdtymkasap
      241 ynhhgsrdsg pppstvseae fedimkrnra isssaiskav sgasagdysd aietlltaia
      301 vikqsrvand ercrvlissl kdclhgieak sysvgasgss srkrhrsrer spsrsressr
      361 rhrdllhned rhddyfqern reherhrdre rdrhh
//
LOCUS       XP_054225986             395 aa            linear   PRI 05-AUG-2025
DEFINITION  cleavage and polyadenylation specificity factor subunit 7 isoform
            X8 [Homo sapiens].
ACCESSION   XP_054225986
VERSION     XP_054225986.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370011.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..395
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..395
                     /product="cleavage and polyadenylation specificity factor
                     subunit 7 isoform X8"
                     /calculated_mol_wt=44076
     Region          <41..>254
                     /region_name="PHA03377"
                     /note="EBNA-3C; Provisional"
                     /db_xref="CDD:177614"
     Region          81..170
                     /region_name="RRM_CFIm59"
                     /note="RNA recognition motif (RRM) found in pre-mRNA
                     cleavage factor Im 59 kDa subunit (CFIm59 or CPSF7) and
                     similar proteins; cd12644"
                     /db_xref="CDD:410049"
     Site            order(91..96,112,114..115,117..124)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410049"
     CDS             1..395
                     /gene="CPSF7"
                     /gene_synonym="CFIm59"
                     /coded_by="XM_054370011.1:148..1335"
                     /db_xref="GeneID:79869"
                     /db_xref="HGNC:HGNC:30098"
                     /db_xref="MIM:621247"
ORIGIN      
        1 msegvdlidi yadeefnqdp efnntdqidl yddvltatsq psddrssste ppppvrqeps
       61 pkpnnktpai lytysglrnr raavyvgsfs wwttdqqliq virsigvydv velkfaenra
      121 ngqskgyaev vvasensvhk llellpgkvl ngekvdvrpa trqnlsqfea qarkrippra
      181 hsrdssdsad gratpsenlv pssarvdkpp svlpyfnrpp salplmvgpp pdtymkasap
      241 ynhhgsrdsg pppstvseae fedimkrnra isssaiskav sgasagdysd aietlltaia
      301 vikqsrvand ercrvlissl kdclhgieak sysvgasgss srkrhrsrer spsrsressr
      361 rhrdllhned rhddyfqern reherhrdre rdrhh
//
LOCUS       XP_054225987             395 aa            linear   PRI 05-AUG-2025
DEFINITION  cleavage and polyadenylation specificity factor subunit 7 isoform
            X8 [Homo sapiens].
ACCESSION   XP_054225987
VERSION     XP_054225987.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370012.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..395
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..395
                     /product="cleavage and polyadenylation specificity factor
                     subunit 7 isoform X8"
                     /calculated_mol_wt=44076
     Region          <41..>254
                     /region_name="PHA03377"
                     /note="EBNA-3C; Provisional"
                     /db_xref="CDD:177614"
     Region          81..170
                     /region_name="RRM_CFIm59"
                     /note="RNA recognition motif (RRM) found in pre-mRNA
                     cleavage factor Im 59 kDa subunit (CFIm59 or CPSF7) and
                     similar proteins; cd12644"
                     /db_xref="CDD:410049"
     Site            order(91..96,112,114..115,117..124)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410049"
     CDS             1..395
                     /gene="CPSF7"
                     /gene_synonym="CFIm59"
                     /coded_by="XM_054370012.1:79..1266"
                     /db_xref="GeneID:79869"
                     /db_xref="HGNC:HGNC:30098"
                     /db_xref="MIM:621247"
ORIGIN      
        1 msegvdlidi yadeefnqdp efnntdqidl yddvltatsq psddrssste ppppvrqeps
       61 pkpnnktpai lytysglrnr raavyvgsfs wwttdqqliq virsigvydv velkfaenra
      121 ngqskgyaev vvasensvhk llellpgkvl ngekvdvrpa trqnlsqfea qarkrippra
      181 hsrdssdsad gratpsenlv pssarvdkpp svlpyfnrpp salplmvgpp pdtymkasap
      241 ynhhgsrdsg pppstvseae fedimkrnra isssaiskav sgasagdysd aietlltaia
      301 vikqsrvand ercrvlissl kdclhgieak sysvgasgss srkrhrsrer spsrsressr
      361 rhrdllhned rhddyfqern reherhrdre rdrhh
//
LOCUS       XP_054225988             381 aa            linear   PRI 05-AUG-2025
DEFINITION  cleavage and polyadenylation specificity factor subunit 7 isoform
            X9 [Homo sapiens].
ACCESSION   XP_054225988
VERSION     XP_054225988.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370013.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..381
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..381
                     /product="cleavage and polyadenylation specificity factor
                     subunit 7 isoform X9"
                     /calculated_mol_wt=41826
     Region          2..80
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:473069"
     CDS             1..381
                     /gene="CPSF7"
                     /gene_synonym="CFIm59"
                     /coded_by="XM_054370013.1:149..1294"
                     /db_xref="GeneID:79869"
                     /db_xref="HGNC:HGNC:30098"
                     /db_xref="MIM:621247"
ORIGIN      
        1 mwttdqqliq virsigvydv velkfaenra ngqskgyaev vvasensvhk llellpgkvl
       61 ngekvdvrpa trqnlsqfea qarkrecvrv prggipprah srdssdsadg ratpsenlvp
      121 ssarvdkpps vlpyfnrpps alplmglppp pippppplss sfgvpppppg ihyqhlmppp
      181 prlpphlavp ppgaippalh lnpaffpppn atvgpppdty mkasapynhh gsrdsgppps
      241 tvseaefedi mkrnraisss aiskavsgas agdysdaiet lltaiavikq srvandercr
      301 vlisslkdcl hgieaksysv gasgsssrkr hrsrerspsr sressrrhrd llhnedrhdd
      361 yfqernrehe rhrdrerdrh h
//
LOCUS       XP_054225989             844 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 15 isoform X1 [Homo sapiens].
ACCESSION   XP_054225989
VERSION     XP_054225989.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370014.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..844
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..844
                     /product="coiled-coil domain-containing protein 15 isoform
                     X1"
                     /calculated_mol_wt=97683
     CDS             1..844
                     /gene="CCDC15"
                     /coded_by="XM_054370014.1:303..2837"
                     /db_xref="GeneID:80071"
                     /db_xref="HGNC:HGNC:25798"
                     /db_xref="MIM:621146"
ORIGIN      
        1 mlgsmarkkp rntsrlplal nplkskdvla vlaerneaiv pvgawvepas pgsseipayt
       61 saylieeelk eqlrkkqeal khfqkqvkyr vnqqirlrkk qqlqksyera qkegsiamqs
      121 sathltskrt svfpnnlnva igssrlppsl mpgdgiedee nqnelfqqqa qalsetmkqa
      181 rhrlasfktv ikkkgsvfpd dgrksfltre evlsrkpast gintgirgel pikvhqglla
      241 avpyqnymen qeldyeepdy eessslvtde kgkedlfgrg qqdqqaihse dknkpfsrvq
      301 kvkfknplfv lmeeeeqkql hfeglqdilp eaqdyfleaq gdlletqgdl tgiqsvkpdt
      361 qavemkvqvt epegqaiepe gqpiktetqg imlkaqsiel eegsivlktq dflptnqall
      421 tknqdvllkd hcvlpkdqsi llkyqdqdfl prdqhvlhkd qdilpkyqdq nflpkdqnfl
      481 srdqhvlpkd qdilpkyqdq nflpkdqnfl srdqhvlpkd qnilpkyqdq dflpkdqdfl
      541 srdqhvlpkd wnilpkcqdq dflprdqgvl pkdqnilpic qdqdflprdq gylpkdqnil
      601 picqdrdflp rdlhvlsndq nilpkcqdqd flpkyqkasl kqptsiligr rgrealpldv
      661 hqdllcrhhq asirgkkvhf kepysdmtde kgredfslad yqclppksqd qddiknqqpa
      721 sfmreervre elpldyhqyv vpkiqdqdsp reqnkhiklp ssfekweiar gntpgvplay
      781 dryqsglste fqaplafqsd vdkeedkker qkqylrhrrl fmdiereqvk eqqrqkeqkk
      841 kiek
//
LOCUS       XP_054225990             814 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 15 isoform X2 [Homo sapiens].
ACCESSION   XP_054225990
VERSION     XP_054225990.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370015.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..814
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..814
                     /product="coiled-coil domain-containing protein 15 isoform
                     X2"
                     /calculated_mol_wt=94060
     CDS             1..814
                     /gene="CCDC15"
                     /coded_by="XM_054370015.1:261..2705"
                     /db_xref="GeneID:80071"
                     /db_xref="HGNC:HGNC:25798"
                     /db_xref="MIM:621146"
ORIGIN      
        1 mlgsmarkkp rntsrlplal nplkskdvla vlaerneaiv pvgawvepas pgsseipayt
       61 saylieeelk eqlrkkqeal khfqkqvkyr vnqqirlrkk qqlqksyera qkegsiamqs
      121 sathltskrt svfpnnlnva igssrlppsl mpgdgiedee nqnelfqqqa qalsetmkqa
      181 rhrlasfktv ikkkgsvfpd dgrksfltre evlsrkpast gintgirgel pikvhqglla
      241 avpyqnymen qeldyeepdy eessslvtde kgkedlfgrg qqdqqaihse dknkpfsrvq
      301 kvkfknplfv lmeeeeqkql hfeglqdilp eaqdyfleaq gdlletqgdl tgiqsvkpdt
      361 qavemkvqvt epegqaiepe gqpiktetqg imlkaqsiel eegsivlktq dflptnqall
      421 tknqdvllkd hcvlpkdqsi llkyqdqdfl prdqhvlhkd qdilpkyqdq nflpkdqnfl
      481 srdqhvlpkd qnilpkyqdq dflpkdqdfl srdqhvlpkd wnilpkcqdq dflprdqgvl
      541 pkdqnilpic qdqdflprdq gylpkdqnil picqdrdflp rdlhvlsndq nilpkcqdqd
      601 flpkyqkasl kqptsiligr rgrealpldv hqdllcrhhq asirgkkvhf kepysdmtde
      661 kgredfslad yqclppksqd qddiknqqpa sfmreervre elpldyhqyv vpkiqdqdsp
      721 reqnkhiklp ssfekweiar gntpgvplay dryqsglste fqaplafqsd vdkeedkker
      781 qkqylrhrrl fmdiereqvk eqqrqkeqkk kiek
//
LOCUS       XP_054225991             808 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 15 isoform X3 [Homo sapiens].
ACCESSION   XP_054225991
VERSION     XP_054225991.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370016.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..808
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..808
                     /product="coiled-coil domain-containing protein 15 isoform
                     X3"
                     /calculated_mol_wt=93286
     CDS             1..808
                     /gene="CCDC15"
                     /coded_by="XM_054370016.1:303..2729"
                     /db_xref="GeneID:80071"
                     /db_xref="HGNC:HGNC:25798"
                     /db_xref="MIM:621146"
ORIGIN      
        1 mlgsmarkkp rntsrlplal nplkskdvla vlaerneaiv pvgawvepas pgsseipayt
       61 saylieeelk eqlrkkqeal khfqkqvkyr vnqqirlrkk qqlqksyera qkegsiamqs
      121 sathltskrt svfpnnlnva igssrlppsl mpgdgiedee nqnelfqqqa qalsetmkqa
      181 rhrlasfktv ikkkgsvfpd dgrksfltre evlsrkpast gintgirgel pikvhqglla
      241 avpyqnymen qeldyeepdy eessslvtde kgkedlfgrg qqdqqaihse dknkpfsrvq
      301 kvkfknplfv lmeeeeqkql hfeglqdilp eaqdyfleaq gdlletqgdl tgiqsvkpdt
      361 qavemkvqvt epegqaiepe gqpiktetqg imlkaqsiel eegsivlktq dflptnqall
      421 tknqdvllkd hcvlpkdqsi llkyqdqdfl prdqhvlhkd qdilpkyqdq nflpkdqnfl
      481 srdqhvlpkd qdilpkyqdq nflpkdqnfl srdqhvlpkd qnilpkyqdq dflpkdqdfl
      541 srdqhvlpkd wnilpkcqdq dflprdqgvl pkdqnilpic qdqdflprdq gylpkdqnil
      601 picqdrdflp rdlhvlsndq nilpkcqdqd flpkyqkasl kqptsiligr rgrealpldv
      661 hqdllcrhhq asirgkkvhf kepysdmtde kgredfslad yqclppksqd qddiknqnkh
      721 iklpssfekw eiargntpgv playdryqsg lstefqapla fqsdvdkeed kkerqkqylr
      781 hrrlfmdier eqvkeqqrqk eqkkkiek
//
LOCUS       XP_054225992             795 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 15 isoform X4 [Homo sapiens].
ACCESSION   XP_054225992
VERSION     XP_054225992.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370017.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..795
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..795
                     /product="coiled-coil domain-containing protein 15 isoform
                     X4"
                     /calculated_mol_wt=92444
     CDS             1..795
                     /gene="CCDC15"
                     /coded_by="XM_054370017.1:1545..3932"
                     /db_xref="GeneID:80071"
                     /db_xref="HGNC:HGNC:25798"
                     /db_xref="MIM:621146"
ORIGIN      
        1 mnagntpqdl tsaylieeel keqlrkkqea lkhfqkqvky rvnqqirlrk kqqlqksyer
       61 aqkegsiamq ssathltskr tsvfpnnlnv aigssrlpps lmpgdgiede enqnelfqqq
      121 aqalsetmkq arhrlasfkt vikkkgsvfp ddgrksfltr eevlsrkpas tgintgirge
      181 lpikvhqgll aavpyqnyme nqeldyeepd yeessslvtd ekgkedlfgr gqqdqqaihs
      241 edknkpfsrv qkvkfknplf vlmeeeeqkq lhfeglqdil peaqdyflea qgdlletqgd
      301 ltgiqsvkpd tqavemkvqv tepegqaiep egqpiktetq gimlkaqsie leegsivlkt
      361 qdflptnqal ltknqdvllk dhcvlpkdqs illkyqdqdf lprdqhvlhk dqdilpkyqd
      421 qnflpkdqnf lsrdqhvlpk dqdilpkyqd qnflpkdqnf lsrdqhvlpk dqnilpkyqd
      481 qdflpkdqdf lsrdqhvlpk dwnilpkcqd qdflprdqgv lpkdqnilpi cqdqdflprd
      541 qgylpkdqni lpicqdrdfl prdlhvlsnd qnilpkcqdq dflpkyqkas lkqptsilig
      601 rrgrealpld vhqdllcrhh qasirgkkvh fkepysdmtd ekgredfsla dyqclppksq
      661 dqddiknqqp asfmreervr eelpldyhqy vvpkiqdqds preqnkhikl pssfekweia
      721 rgntpgvpla ydryqsglst efqaplafqs dvdkeedkke rqkqylrhrr lfmdiereqv
      781 keqqrqkeqk kkiek
//
LOCUS       XP_054225993             768 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 15 isoform X5 [Homo sapiens].
ACCESSION   XP_054225993
VERSION     XP_054225993.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370018.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..768
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..768
                     /product="coiled-coil domain-containing protein 15 isoform
                     X5"
                     /calculated_mol_wt=88804
     CDS             1..768
                     /gene="CCDC15"
                     /coded_by="XM_054370018.1:303..2609"
                     /db_xref="GeneID:80071"
                     /db_xref="HGNC:HGNC:25798"
                     /db_xref="MIM:621146"
ORIGIN      
        1 mlgsmarkkp rntsrlplal nplkskdvla vlaerneaiv pvgawvepas pgsseipayt
       61 saylieeelk eqlrkkqeal khfqkqvkyr vnqqirlrkk qqlqksyera qkegsiamqs
      121 sathltskrt svfpnnlnva igssrlppsl mpgdgiedee nqnelfqqqa qalsetmkqa
      181 rhrlasfktv ikkkgsvfpd dgrksfltre evlsrkpast gintgirgel pikvhqglla
      241 avpyqnymen qeldyeepdy eessslvtde kgkedlfgrg qqdqqaihse dknkpfsrvq
      301 kvkfknplfv lmeeeeqkql hfeglqdilp eaqdyfleaq gdlletqgdl tgiqsvkpdt
      361 qavemkvqvt epegqaiepe gqpiktetqg imlkaqsiel eegsivlktq dflptnqall
      421 tknqdvllkd hcvlpkdqsi llkyqdqdfl prdqhvlhkd qdilpkyqdq nflpkdqnfl
      481 srdqhvlpkd qdilpkyqdq nflpkdqnfl srdqhvlpkd qnilpkyqdq dflpkdqdfl
      541 srdqhvlpkd wnilpkcqdq dflprdqgvl pkdqnilpic qdqdflprdq gylpkdqnil
      601 picqdrdflp rdlhvlsndq nilpkcqdqd flpkyqkvhf kepysdmtde kgredfslad
      661 yqclppksqd qddiknqnkh iklpssfekw eiargntpgv playdryqsg lstefqapla
      721 fqsdvdkeed kkerqkqylr hrrlfmdier eqvkeqqrqk eqkkkiek
//
LOCUS       XP_054225994             763 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 15 isoform X6 [Homo sapiens].
ACCESSION   XP_054225994
VERSION     XP_054225994.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370019.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..763
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..763
                     /product="coiled-coil domain-containing protein 15 isoform
                     X6"
                     /calculated_mol_wt=88371
     CDS             1..763
                     /gene="CCDC15"
                     /coded_by="XM_054370019.1:303..2594"
                     /db_xref="GeneID:80071"
                     /db_xref="HGNC:HGNC:25798"
                     /db_xref="MIM:621146"
ORIGIN      
        1 mlgsmarkkp rntsrlplal nplkskdvla vlaerneaiv pvgawvepas pgsseipayt
       61 saylieeelk eqlrkkqeal khfqkqvkyr vnqqirlrkk qqlqksyera qkegsiamqs
      121 sathltskrt svfpnnlnva igssrlppsl mpgdgiedee nqnelfqqqa qalsetmkqa
      181 rhrlasfktv ikkkgsvfpd dgrksfltre evlsrkpast gintgirgel pikvhqglla
      241 avpyqnymen qeldyeepdy eessslvtde kgkedlfgrg qqdqqaihse dknkpfsrvq
      301 kvkfknplfv lmeeeeqkql hfeglqdilp eaqdyfleaq gdlletqgdl tgiqsvkpdt
      361 qavemkvqvt epegqaiepe gqpiktetqg imlkaqsiel eegsivlktq dflptnqall
      421 tknqdvllkd hcvlpkdqsi llkyqdqdfl prdqhvlhkd qdilpkyqdq nflpkdqnfl
      481 srdqhvlpkd qdilpkyqdq nflpkdqnfl srdqhvlpkd qnilpkyqdq dflpkdqdfl
      541 srdqhvlpkd wnilpkcqdq dflprdqgvl pkdqnilpic qdqdflprdq gylpkdqnil
      601 picqdrdflp rdlhvlsndq nilpkcqdqd flpkyqqpas fmreervree lpldyhqyvv
      661 pkiqdqdspr eqnkhiklps sfekweiarg ntpgvplayd ryqsglstef qaplafqsdv
      721 dkeedkkerq kqylrhrrlf mdiereqvke qqrqkeqkkk iek
//
LOCUS       XP_054225995             755 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 15 isoform X7 [Homo sapiens].
ACCESSION   XP_054225995
VERSION     XP_054225995.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370020.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..755
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..755
                     /product="coiled-coil domain-containing protein 15 isoform
                     X7"
                     /calculated_mol_wt=87962
     CDS             1..755
                     /gene="CCDC15"
                     /coded_by="XM_054370020.1:1745..4012"
                     /db_xref="GeneID:80071"
                     /db_xref="HGNC:HGNC:25798"
                     /db_xref="MIM:621146"
ORIGIN      
        1 mnagntpqdl tsaylieeel keqlrkkqea lkhfqkqvky rvnqqirlrk kqqlqksyer
       61 aqkegsiamq ssathltskr tsvfpnnlnv aigssrlpps lmpgdgiede enqnelfqqq
      121 aqalsetmkq arhrlasfkt vikkkgsvfp ddgrksfltr eevlsrkpas tgintgirge
      181 lpikvhqgll aavpyqnyme nqeldyeepd yeessslvtd ekgkedlfgr gqqdqqaihs
      241 edknkpfsrv qkvkfknplf vlmeeeeqkq lhfeglqdil peaqdyflea qgdlletqgd
      301 ltgiqsvkpd tqavemkvqv tepegqaiep egqpiktetq gimlkaqsie leegsivlkt
      361 qdflptnqal ltknqdvllk dhcvlpkdqs illkyqdqdf lprdqhvlhk dqdilpkyqd
      421 qnflpkdqnf lsrdqhvlpk dqdilpkyqd qnflpkdqnf lsrdqhvlpk dqnilpkyqd
      481 qdflpkdqdf lsrdqhvlpk dwnilpkcqd qdflprdqgv lpkdqnilpi cqdqdflprd
      541 qgylpkdqni lpicqdrdfl prdlhvlsnd qnilpkcqdq dflpkyqkvh fkepysdmtd
      601 ekgredfsla dyqclppksq dqddiknqqp asfmreervr eelpldyhqy vvpkiqdqds
      661 preqnkhikl pssfekweia rgntpgvpla ydryqsglst efqaplafqs dvdkeedkke
      721 rqkqylrhrr lfmdiereqv keqqrqkeqk kkiek
//
LOCUS       XP_054225996             727 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 15 isoform X8 [Homo sapiens].
ACCESSION   XP_054225996
VERSION     XP_054225996.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370021.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..727
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..727
                     /product="coiled-coil domain-containing protein 15 isoform
                     X8"
                     /calculated_mol_wt=83974
     CDS             1..727
                     /gene="CCDC15"
                     /coded_by="XM_054370021.1:303..2486"
                     /db_xref="GeneID:80071"
                     /db_xref="HGNC:HGNC:25798"
                     /db_xref="MIM:621146"
ORIGIN      
        1 mlgsmarkkp rntsrlplal nplkskdvla vlaerneaiv pvgawvepas pgsseipayt
       61 saylieeelk eqlrkkqeal khfqkqvkyr vnqqirlrkk qqlqksyera qkegsiamqs
      121 sathltskrt svfpnnlnva igssrlppsl mpgdgiedee nqnelfqqqa qalsetmkqa
      181 rhrlasfktv ikkkgsvfpd dgrksfltre evlsrkpast gintgirgel pikvhqglla
      241 avpyqnymen qeldyeepdy eessslvtde kgkedlfgrg qqdqqaihse dknkpfsrvq
      301 kvkfknplfv lmeeeeqkql hfeglqdilp eaqdyfleaq gdlletqgdl tgiqsvkpdt
      361 qavemkvqvt epegqaiepe gqpiktetqg imlkaqsiel eegsivlktq dflptnqall
      421 tknqdvllkd hcvlpkdqsi llkyqdqdfl prdqhvlhkd qdilpkyqdq nflpkdqnfl
      481 srdqhvlpkd qdilpkyqdq nflpkdqnfl srdqhvlpkd qnilpkyqdq dflpkdqdfl
      541 srdqhvlpkd wnilpkcqdq dflprdqgvl pkdqnilpic qdqdflprdq gylpkdqnil
      601 picqdrdflp rdlhvlsndq nilpkcqdqd flpkyqnkhi klpssfekwe iargntpgvp
      661 laydryqsgl stefqaplaf qsdvdkeedk kerqkqylrh rrlfmdiere qvkeqqrqke
      721 qkkkiek
//
LOCUS       XP_054225997             727 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 15 isoform X9 [Homo sapiens].
ACCESSION   XP_054225997
VERSION     XP_054225997.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370022.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..727
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..727
                     /product="coiled-coil domain-containing protein 15 isoform
                     X9"
                     /calculated_mol_wt=84346
     CDS             1..727
                     /gene="CCDC15"
                     /coded_by="XM_054370022.1:261..2444"
                     /db_xref="GeneID:80071"
                     /db_xref="HGNC:HGNC:25798"
                     /db_xref="MIM:621146"
ORIGIN      
        1 mqssathlts krtsvfpnnl nvaigssrlp pslmpgdgie deenqnelfq qqaqalsetm
       61 kqarhrlasf ktvikkkgsv fpddgrksfl treevlsrkp astgintgir gelpikvhqg
      121 llaavpyqny menqeldyee pdyeessslv tdekgkedlf grgqqdqqai hsedknkpfs
      181 rvqkvkfknp lfvlmeeeeq kqlhfeglqd ilpeaqdyfl eaqgdlletq gdltgiqsvk
      241 pdtqavemkv qvtepegqai epegqpikte tqgimlkaqs ieleegsivl ktqdflptnq
      301 alltknqdvl lkdhcvlpkd qsillkyqdq dflprdqhvl hkdqdilpky qdqnflpkdq
      361 nflsrdqhvl pkdqdilpky qdqnflpkdq nflsrdqhvl pkdqnilpky qdqdflpkdq
      421 dflsrdqhvl pkdwnilpkc qdqdflprdq gvlpkdqnil picqdqdflp rdqgylpkdq
      481 nilpicqdrd flprdlhvls ndqnilpkcq dqdflpkyqk aslkqptsil igrrgrealp
      541 ldvhqdllcr hhqasirgkk vhfkepysdm tdekgredfs ladyqclppk sqdqddiknq
      601 qpasfmreer vreelpldyh qyvvpkiqdq dspreqnkhi klpssfekwe iargntpgvp
      661 laydryqsgl stefqaplaf qsdvdkeedk kerqkqylrh rrlfmdiere qvkeqqrqke
      721 qkkkiek
//
LOCUS       XP_054225998             702 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 15 isoform X10 [Homo
            sapiens].
ACCESSION   XP_054225998
VERSION     XP_054225998.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370023.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..702
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..702
                     /product="coiled-coil domain-containing protein 15 isoform
                     X10"
                     /calculated_mol_wt=81173
     CDS             1..702
                     /gene="CCDC15"
                     /coded_by="XM_054370023.1:303..2411"
                     /db_xref="GeneID:80071"
                     /db_xref="HGNC:HGNC:25798"
                     /db_xref="MIM:621146"
ORIGIN      
        1 mlgsmarkkp rntsrlplal nplkskdvla vlaerneaiv pvgawvepas pgsseipayt
       61 saylieeelk eqlrkkqeal khfqkqvkyr vnqqirlrkk qqlqksyera qkegsiamqs
      121 sathltskrt svfpnnlnva igssrlppsl mpgdgiedee nqnelfqqqa qalsetmkqa
      181 rhrlasfktv ikkkgsvfpd dgrksfltre evlsrkpast gintgirgel pikvhqglla
      241 avpyqnymen qeldyeepdy eessslvtde kgkedlfgrg qqdqqaihse dknkpfsrvq
      301 kvkfknplfv lmeeeeqkql hfeglqdilp eaqdyfleaq gdlletqgdl tgiqsvkpdt
      361 qavemkvqvt epegqaiepe gqpiktetqg imlkaqsiel eegsivlktq dflptnqall
      421 tknqdvllkd hcvlpkdqsi llkyqdqdfl prdqhvlhkd qdilpkyqdq nflpkdqnfl
      481 srdqhvlpkd qdilpkyqdq nflpkdqnfl srdqhvlpkd qnilpkyqdq dflpkdqdfl
      541 srdqhvlpkd wnilpkcqdq dflprdqgvl pkdqnilpic qdqdflprdq gylpkdqnil
      601 picqdrdflp rdlhvlsndq nilpkcqdqd flpkyqaydr yqsglstefq aplafqsdvd
      661 keedkkerqk qylrhrrlfm diereqvkeq qrqkeqkkki ek
//
LOCUS       XP_054225999             653 aa            linear   PRI 05-AUG-2025
DEFINITION  coiled-coil domain-containing protein 15 isoform X11 [Homo
            sapiens].
ACCESSION   XP_054225999
VERSION     XP_054225999.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370024.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..653
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..653
                     /product="coiled-coil domain-containing protein 15 isoform
                     X11"
                     /calculated_mol_wt=75935
     CDS             1..653
                     /gene="CCDC15"
                     /coded_by="XM_054370024.1:1745..3706"
                     /db_xref="GeneID:80071"
                     /db_xref="HGNC:HGNC:25798"
                     /db_xref="MIM:621146"
ORIGIN      
        1 mnagntpqdl tsaylieeel keqlrkkqea lkhfqkqvky rvnqqirlrk kqqlqksyer
       61 aqkegsiamq ssathltskr tsvfpnnlnv aigssrlpps lmpgdgiede enqnelfqqq
      121 aqalsetmkq arhrlasfkt vikkkgsvfp ddgrksfltr eevlsrkpas tgintgirge
      181 lpikvhqgll aavpyqnyme nqeldyeepd yeessslvtd ekgkedlfgr gqqdqqaihs
      241 edknkpfsrv qkvkfknplf vlmeeeeqkq lhfeglqdil peaqdyflea qgdlletqgd
      301 ltgiqsvkpd tqavemkvqv tepegqaiep egqpiktetq gimlkaqsie leegsivlkt
      361 qdflptnqal ltknqdvllk dhcvlpkdqs illkyqdqdf lprdqhvlhk dqdilpkyqd
      421 qnflpkdqnf lsrdqhvlpk dqdilpkyqd qnflpkdqnf lsrdqhvlpk dqnilpkyqd
      481 qdflpkdqdf lsrdqhvlpk dwnilpkcqd qdflprdqgv lpkdqnilpi cqdqdflprd
      541 qgylpkdqni lpicqdrdfl prdlhvlsnd qnilpkcqdq dflpkyqayd ryqsglstef
      601 qaplafqsdv dkeedkkerq kqylrhrrlf mdiereqvke qqrqkeqkkk iek
//
LOCUS       XP_054226000             224 aa            linear   PRI 05-AUG-2025
DEFINITION  isoaspartyl peptidase/L-asparaginase isoform X1 [Homo sapiens].
ACCESSION   XP_054226000
VERSION     XP_054226000.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370025.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..224
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..224
                     /product="isoaspartyl peptidase/L-asparaginase isoform X1"
                     /calculated_mol_wt=23390
     Region          2..>203
                     /region_name="ASRGL1_like"
                     /note="Metazoan L-Asparaginase type 2; cd04702"
                     /db_xref="CDD:271338"
     CDS             1..224
                     /gene="ASRGL1"
                     /gene_synonym="ALP; ALP1; CRASH"
                     /coded_by="XM_054370025.1:139..813"
                     /db_xref="GeneID:80150"
                     /db_xref="HGNC:HGNC:16448"
                     /db_xref="MIM:609212"
ORIGIN      
        1 mnpivvvhgg gagpiskdrk ervhqgmvra atvgygilre ggsavdaveg avvaleddpe
       61 fnagcgsvln tngevemdas imdgkdlsag avsavqcian piklarlvme ktphcfltdq
      121 gaaqfaaamg vpeipgeklv ternkkrlek ekhekgaqkt dcqknlgtvg avaldckgnv
      181 ayatstggiv nkmvgrvgds pcldektevw rnaiftlane darm
//
LOCUS       XP_054226001             218 aa            linear   PRI 05-AUG-2025
DEFINITION  isoaspartyl peptidase/L-asparaginase isoform X2 [Homo sapiens].
ACCESSION   XP_054226001
VERSION     XP_054226001.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370026.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..218
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..218
                     /product="isoaspartyl peptidase/L-asparaginase isoform X2"
                     /calculated_mol_wt=22773
     Region          2..>203
                     /region_name="ASRGL1_like"
                     /note="Metazoan L-Asparaginase type 2; cd04702"
                     /db_xref="CDD:271338"
     CDS             1..218
                     /gene="ASRGL1"
                     /gene_synonym="ALP; ALP1; CRASH"
                     /coded_by="XM_054370026.1:139..795"
                     /db_xref="GeneID:80150"
                     /db_xref="HGNC:HGNC:16448"
                     /db_xref="MIM:609212"
ORIGIN      
        1 mnpivvvhgg gagpiskdrk ervhqgmvra atvgygilre ggsavdaveg avvaleddpe
       61 fnagcgsvln tngevemdas imdgkdlsag avsavqcian piklarlvme ktphcfltdq
      121 gaaqfaaamg vpeipgeklv ternkkrlek ekhekgaqkt dcqknlgtvg avaldckgnv
      181 ayatstggiv nkmvgrvgds pcleqspfls rswrlcrq
//
LOCUS       XP_054226004             737 aa            linear   PRI 05-AUG-2025
DEFINITION  protein-glucosylgalactosylhydroxylysine glucosidase isoform X1
            [Homo sapiens].
ACCESSION   XP_054226004
VERSION     XP_054226004.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370029.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..737
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..737
                     /product="protein-glucosylgalactosylhydroxylysine
                     glucosidase isoform X1"
                     /calculated_mol_wt=80524
     Region          <211..649
                     /region_name="ATH1"
                     /note="Kojibiose phosphorylase YcjT [Carbohydrate
                     transport and metabolism]; COG1554"
                     /db_xref="CDD:441163"
     CDS             1..737
                     /gene="PGGHG"
                     /gene_synonym="ATHL1"
                     /coded_by="XM_054370029.1:1139..3352"
                     /db_xref="GeneID:80162"
                     /db_xref="HGNC:HGNC:26210"
                     /db_xref="MIM:617032"
ORIGIN      
        1 medagedptt faahslpsdp rllatvtnay lgtrvfhdtl hvsgvyngag gdthramlps
       61 plnvrleapa gmgeqltetf aldtntgsfl htlegprfra sqciyahrtl phvlafrvsi
      121 arlapgsgpi tlllrsafsp espdldlhqg pdfqgaryly ghtltpeqpg gpqqevhmlw
      181 tpappdltlg egeeartwdf ltavggsqae aqacltealq lqargalyta haqawaqlwv
      241 ecgldvvgpl qlrqalrgsl yyllsalpqp kapgyichgl spgglsngsr eecywghvfw
      301 dqdlwmfpsi lmfhpeaara ileyrirtld galenaqnlg yqgakfawes adsglevcpe
      361 diygvqevhv ngavvlafel yyhttqdlql freaggwdvv ravaefwcsr vewspreeky
      421 hlrgvmspde yhsgvnnsvy tnvlvqnslr faaalaqdlg lpipsqwlav adkikvpfdv
      481 eqnfhpefdg yepgevvkqa dvvllgypvp fslspdvrrk nleiyeavts pqgpamtwsm
      541 favgwmelkd avrarglldr sfanmaepfk vwtenadgsg avnfltgmgg flqavvfgct
      601 gfrvtragvt fdpvclsgis rvsvsgifyq gnklnfsfse dsvtvevtar agpwaphlea
      661 elwpsqsrls llpghkvsfp rsagriqmsp pklpgsssse fpgrtfsdvr dplqsplwvt
      721 lgsssptesl tvdpase
//
LOCUS       XP_054226005             737 aa            linear   PRI 05-AUG-2025
DEFINITION  protein-glucosylgalactosylhydroxylysine glucosidase isoform X1
            [Homo sapiens].
ACCESSION   XP_054226005
VERSION     XP_054226005.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370030.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..737
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..737
                     /product="protein-glucosylgalactosylhydroxylysine
                     glucosidase isoform X1"
                     /calculated_mol_wt=80524
     Region          <211..649
                     /region_name="ATH1"
                     /note="Kojibiose phosphorylase YcjT [Carbohydrate
                     transport and metabolism]; COG1554"
                     /db_xref="CDD:441163"
     CDS             1..737
                     /gene="PGGHG"
                     /gene_synonym="ATHL1"
                     /coded_by="XM_054370030.1:1617..3830"
                     /db_xref="GeneID:80162"
                     /db_xref="HGNC:HGNC:26210"
                     /db_xref="MIM:617032"
ORIGIN      
        1 medagedptt faahslpsdp rllatvtnay lgtrvfhdtl hvsgvyngag gdthramlps
       61 plnvrleapa gmgeqltetf aldtntgsfl htlegprfra sqciyahrtl phvlafrvsi
      121 arlapgsgpi tlllrsafsp espdldlhqg pdfqgaryly ghtltpeqpg gpqqevhmlw
      181 tpappdltlg egeeartwdf ltavggsqae aqacltealq lqargalyta haqawaqlwv
      241 ecgldvvgpl qlrqalrgsl yyllsalpqp kapgyichgl spgglsngsr eecywghvfw
      301 dqdlwmfpsi lmfhpeaara ileyrirtld galenaqnlg yqgakfawes adsglevcpe
      361 diygvqevhv ngavvlafel yyhttqdlql freaggwdvv ravaefwcsr vewspreeky
      421 hlrgvmspde yhsgvnnsvy tnvlvqnslr faaalaqdlg lpipsqwlav adkikvpfdv
      481 eqnfhpefdg yepgevvkqa dvvllgypvp fslspdvrrk nleiyeavts pqgpamtwsm
      541 favgwmelkd avrarglldr sfanmaepfk vwtenadgsg avnfltgmgg flqavvfgct
      601 gfrvtragvt fdpvclsgis rvsvsgifyq gnklnfsfse dsvtvevtar agpwaphlea
      661 elwpsqsrls llpghkvsfp rsagriqmsp pklpgsssse fpgrtfsdvr dplqsplwvt
      721 lgsssptesl tvdpase
//
LOCUS       XP_054226006             719 aa            linear   PRI 05-AUG-2025
DEFINITION  protein-glucosylgalactosylhydroxylysine glucosidase isoform X2
            [Homo sapiens].
ACCESSION   XP_054226006
VERSION     XP_054226006.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370031.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..719
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..719
                     /product="protein-glucosylgalactosylhydroxylysine
                     glucosidase isoform X2"
                     /calculated_mol_wt=78664
     Region          <211..631
                     /region_name="ATH1"
                     /note="Kojibiose phosphorylase YcjT [Carbohydrate
                     transport and metabolism]; COG1554"
                     /db_xref="CDD:441163"
     CDS             1..719
                     /gene="PGGHG"
                     /gene_synonym="ATHL1"
                     /coded_by="XM_054370031.1:1140..3299"
                     /db_xref="GeneID:80162"
                     /db_xref="HGNC:HGNC:26210"
                     /db_xref="MIM:617032"
ORIGIN      
        1 medagedptt faahslpsdp rllatvtnay lgtrvfhdtl hvsgvyngag gdthramlps
       61 plnvrleapa gmgeqltetf aldtntgsfl htlegprfra sqciyahrtl phvlafrvsi
      121 arlapgsgpi tlllrsafsp espdldlhqg pdfqgaryly ghtltpeqpg gpqqevhmlw
      181 tpappdltlg egeeartwdf ltavggsqae aqacltealq lqargalyta haqawaqlwv
      241 ecgldvvgpl qlrqalrgsl yyllsalpqp kapgyichgl spgglsngsr eecywghvfw
      301 dqdlwmfpsi lmfhpeaara ileyrirtld galenaqnlg yqgakfawes adsglevcpe
      361 diygvqevhv ngavvlafel yyhttqdlql freaggwdvv ravaefwcsr vewspreeky
      421 hlrgvmspde yhsgvnnsvy tnvlvqnslr faaalaqdlg lpipsqwlav adkikvpfdv
      481 eqnfhpefdg yepgevvkqa dvvllgypvp fslspdvrrk nleiyeavts pqgpamtwsm
      541 favgwmelkd avrarglldr sfanmaepfk vwtenadgsg avnfltgmgg flqavvfgct
      601 gfrvsvsgif yqgnklnfsf sedsvtvevt aragpwaphl eaelwpsqsr lsllpghkvs
      661 fprsagriqm sppklpgsss sefpgrtfsd vrdplqsplw vtlgssspte sltvdpase
//
LOCUS       XP_054226007             527 aa            linear   PRI 05-AUG-2025
DEFINITION  protein-glucosylgalactosylhydroxylysine glucosidase isoform X3
            [Homo sapiens].
ACCESSION   XP_054226007
VERSION     XP_054226007.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370032.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..527
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..527
                     /product="protein-glucosylgalactosylhydroxylysine
                     glucosidase isoform X3"
                     /calculated_mol_wt=57656
     Region          <211..>502
                     /region_name="ATH1"
                     /note="Kojibiose phosphorylase YcjT [Carbohydrate
                     transport and metabolism]; COG1554"
                     /db_xref="CDD:441163"
     CDS             1..527
                     /gene="PGGHG"
                     /gene_synonym="ATHL1"
                     /coded_by="XM_054370032.1:1144..2727"
                     /db_xref="GeneID:80162"
                     /db_xref="HGNC:HGNC:26210"
                     /db_xref="MIM:617032"
ORIGIN      
        1 medagedptt faahslpsdp rllatvtnay lgtrvfhdtl hvsgvyngag gdthramlps
       61 plnvrleapa gmgeqltetf aldtntgsfl htlegprfra sqciyahrtl phvlafrvsi
      121 arlapgsgpi tlllrsafsp espdldlhqg pdfqgaryly ghtltpeqpg gpqqevhmlw
      181 tpappdltlg egeeartwdf ltavggsqae aqacltealq lqargalyta haqawaqlwv
      241 ecgldvvgpl qlrqalrgsl yyllsalpqp kapgyichgl spgglsngsr eecywghvfw
      301 dqdlwmfpsi lmfhpeaara ileyrirtld galenaqnlg yqgakfawes adsglevcpe
      361 diygvqevhv ngavvlafel yyhttqdlql freaggwdvv ravaefwcsr vewspreeky
      421 hlrgvmspde yhsgvnnsvy tnvlvqnslr faaalaqdlg lpipsqwlav adkikvpfdv
      481 eqnfhpefdg yepgprhdle hvccgldgae grsagpgppg qelcqhg
//
LOCUS       XP_054226008             502 aa            linear   PRI 05-AUG-2025
DEFINITION  protein-glucosylgalactosylhydroxylysine glucosidase isoform X4
            [Homo sapiens].
ACCESSION   XP_054226008
VERSION     XP_054226008.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370033.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..502
                     /product="protein-glucosylgalactosylhydroxylysine
                     glucosidase isoform X4"
                     /calculated_mol_wt=55395
     Region          <211..>502
                     /region_name="ATH1"
                     /note="Kojibiose phosphorylase YcjT [Carbohydrate
                     transport and metabolism]; COG1554"
                     /db_xref="CDD:441163"
     CDS             1..502
                     /gene="PGGHG"
                     /gene_synonym="ATHL1"
                     /coded_by="XM_054370033.1:1144..2652"
                     /db_xref="GeneID:80162"
                     /db_xref="HGNC:HGNC:26210"
                     /db_xref="MIM:617032"
ORIGIN      
        1 medagedptt faahslpsdp rllatvtnay lgtrvfhdtl hvsgvyngag gdthramlps
       61 plnvrleapa gmgeqltetf aldtntgsfl htlegprfra sqciyahrtl phvlafrvsi
      121 arlapgsgpi tlllrsafsp espdldlhqg pdfqgaryly ghtltpeqpg gpqqevhmlw
      181 tpappdltlg egeeartwdf ltavggsqae aqacltealq lqargalyta haqawaqlwv
      241 ecgldvvgpl qlrqalrgsl yyllsalpqp kapgyichgl spgglsngsr eecywghvfw
      301 dqdlwmfpsi lmfhpeaara ileyrirtld galenaqnlg yqgakfawes adsglevcpe
      361 diygvqevhv ngavvlafel yyhttqdlql freaggwdvv ravaefwcsr vewspreeky
      421 hlrgvmspde yhsgvnnsvy tnvlvqnslr faaalaqdlg lpipsqwlav adkikvpfdv
      481 eqnfhpefdg yepgkiwrft rl
//
LOCUS       XP_054226009             499 aa            linear   PRI 05-AUG-2025
DEFINITION  protein-glucosylgalactosylhydroxylysine glucosidase isoform X5
            [Homo sapiens].
ACCESSION   XP_054226009
VERSION     XP_054226009.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370034.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..499
                     /product="protein-glucosylgalactosylhydroxylysine
                     glucosidase isoform X5"
                     /calculated_mol_wt=54781
     Region          <211..>492
                     /region_name="ATH1"
                     /note="Kojibiose phosphorylase YcjT [Carbohydrate
                     transport and metabolism]; COG1554"
                     /db_xref="CDD:441163"
     CDS             1..499
                     /gene="PGGHG"
                     /gene_synonym="ATHL1"
                     /coded_by="XM_054370034.1:1144..2643"
                     /db_xref="GeneID:80162"
                     /db_xref="HGNC:HGNC:26210"
                     /db_xref="MIM:617032"
ORIGIN      
        1 medagedptt faahslpsdp rllatvtnay lgtrvfhdtl hvsgvyngag gdthramlps
       61 plnvrleapa gmgeqltetf aldtntgsfl htlegprfra sqciyahrtl phvlafrvsi
      121 arlapgsgpi tlllrsafsp espdldlhqg pdfqgaryly ghtltpeqpg gpqqevhmlw
      181 tpappdltlg egeeartwdf ltavggsqae aqacltealq lqargalyta haqawaqlwv
      241 ecgldvvgpl qlrqalrgsl yyllsalpqp kapgyichgl spgglsngsr eecywghvfw
      301 dqdlwmfpsi lmfhpeaara ileyrirtld galenaqnlg yqgakfawes adsglevcpe
      361 diygvqevhv ngavvlafel yyhttqdlql freaggwdvv ravaefwcsr vewspreeky
      421 hlrgvmspde yhsgvnnsvy tnvlvqnslr faaalaqdlg lpipsqwlav adkikvpfdv
      481 eqnfhpefdg yepvsgtsl
//
LOCUS       XP_054226010             432 aa            linear   PRI 05-AUG-2025
DEFINITION  protein-glucosylgalactosylhydroxylysine glucosidase isoform X6
            [Homo sapiens].
ACCESSION   XP_054226010
VERSION     XP_054226010.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370035.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..432
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..432
                     /product="protein-glucosylgalactosylhydroxylysine
                     glucosidase isoform X6"
                     /calculated_mol_wt=47487
     Region          <211..>423
                     /region_name="ATH1"
                     /note="Kojibiose phosphorylase YcjT [Carbohydrate
                     transport and metabolism]; COG1554"
                     /db_xref="CDD:441163"
     CDS             1..432
                     /gene="PGGHG"
                     /gene_synonym="ATHL1"
                     /coded_by="XM_054370035.1:1145..2443"
                     /db_xref="GeneID:80162"
                     /db_xref="HGNC:HGNC:26210"
                     /db_xref="MIM:617032"
ORIGIN      
        1 medagedptt faahslpsdp rllatvtnay lgtrvfhdtl hvsgvyngag gdthramlps
       61 plnvrleapa gmgeqltetf aldtntgsfl htlegprfra sqciyahrtl phvlafrvsi
      121 arlapgsgpi tlllrsafsp espdldlhqg pdfqgaryly ghtltpeqpg gpqqevhmlw
      181 tpappdltlg egeeartwdf ltavggsqae aqacltealq lqargalyta haqawaqlwv
      241 ecgldvvgpl qlrqalrgsl yyllsalpqp kapgyichgl spgglsngsr eecywghvfw
      301 dqdlwmfpsi lmfhpeaara ileyrirtld galenaqnlg yqgakfawes adsglevcpe
      361 diygvqevhv ngavvlafel yyhttqdlql freaggwdvv ravaefwcsr vewspreeky
      421 hlrdtsrvpa pr
//
LOCUS       XP_054226011             426 aa            linear   PRI 05-AUG-2025
DEFINITION  protein-glucosylgalactosylhydroxylysine glucosidase isoform X7
            [Homo sapiens].
ACCESSION   XP_054226011
VERSION     XP_054226011.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370036.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..426
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..426
                     /product="protein-glucosylgalactosylhydroxylysine
                     glucosidase isoform X7"
                     /calculated_mol_wt=46831
     Region          <211..>423
                     /region_name="ATH1"
                     /note="Kojibiose phosphorylase YcjT [Carbohydrate
                     transport and metabolism]; COG1554"
                     /db_xref="CDD:441163"
     CDS             1..426
                     /gene="PGGHG"
                     /gene_synonym="ATHL1"
                     /coded_by="XM_054370036.1:1144..2424"
                     /db_xref="GeneID:80162"
                     /db_xref="HGNC:HGNC:26210"
                     /db_xref="MIM:617032"
ORIGIN      
        1 medagedptt faahslpsdp rllatvtnay lgtrvfhdtl hvsgvyngag gdthramlps
       61 plnvrleapa gmgeqltetf aldtntgsfl htlegprfra sqciyahrtl phvlafrvsi
      121 arlapgsgpi tlllrsafsp espdldlhqg pdfqgaryly ghtltpeqpg gpqqevhmlw
      181 tpappdltlg egeeartwdf ltavggsqae aqacltealq lqargalyta haqawaqlwv
      241 ecgldvvgpl qlrqalrgsl yyllsalpqp kapgyichgl spgglsngsr eecywghvfw
      301 dqdlwmfpsi lmfhpeaara ileyrirtld galenaqnlg yqgakfawes adsglevcpe
      361 diygvqevhv ngavvlafel yyhttqdlql freaggwdvv ravaefwcsr vewspreeky
      421 hlrapr
//
LOCUS       XP_054226012             336 aa            linear   PRI 05-AUG-2025
DEFINITION  2-acylglycerol O-acyltransferase 2 isoform X1 [Homo sapiens].
ACCESSION   XP_054226012
VERSION     XP_054226012.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370037.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..336
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..336
                     /product="2-acylglycerol O-acyltransferase 2 isoform X1"
                     /calculated_mol_wt=37913
     Region          41..297
                     /region_name="LPLAT"
                     /note="Lysophospholipid acyltransferases (LPLATs) of
                     glycerophospholipid biosynthesis; cl17185"
                     /db_xref="CDD:473073"
     Site            order(110,113,136..139,187..189)
                     /site_type="active"
                     /note="putative acyl-acceptor binding pocket [active]"
                     /db_xref="CDD:153249"
     CDS             1..336
                     /gene="MOGAT2"
                     /gene_synonym="DGAT2L5; DGAT2L5.; hDC5; MGAT2"
                     /coded_by="XM_054370037.1:52..1062"
                     /db_xref="GeneID:80168"
                     /db_xref="HGNC:HGNC:23248"
                     /db_xref="MIM:610270"
ORIGIN      
        1 mvefaplfvp werrlqtlav lqfvfsflal aeictvgfia llftrfwllt vlyaawwyld
       61 rdkprqggrh iqaircwtiw kymkdyfpis lvktaeldps rnyiagfhph gvlavgafan
      121 lctestgfss ifpgirphlm mltlwfrapf frdyimsagl vtsekesaah ilnrkgggnl
      181 lgiivggaqe aldarpgsft lllrnrkgfv rlalthgapl vpifsfgend lfdqipnssg
      241 swlryiqnrl qkimgislpl fhgrgvfqys fglipyrrpi ttvellpeer teelpsqpgr
      301 trerdelgps wffpgmreat agqrggvegk eelpgl
//
LOCUS       XP_054226013             254 aa            linear   PRI 05-AUG-2025
DEFINITION  2-acylglycerol O-acyltransferase 2 isoform X2 [Homo sapiens].
ACCESSION   XP_054226013
VERSION     XP_054226013.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370038.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..254
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..254
                     /product="2-acylglycerol O-acyltransferase 2 isoform X2"
                     /calculated_mol_wt=28032
     Region          3..215
                     /region_name="LPLAT"
                     /note="Lysophospholipid acyltransferases (LPLATs) of
                     glycerophospholipid biosynthesis; cl17185"
                     /db_xref="CDD:473073"
     Site            order(28,31,54..57,105..107)
                     /site_type="active"
                     /note="putative acyl-acceptor binding pocket [active]"
                     /db_xref="CDD:153249"
     CDS             1..254
                     /gene="MOGAT2"
                     /gene_synonym="DGAT2L5; DGAT2L5.; hDC5; MGAT2"
                     /coded_by="XM_054370038.1:274..1038"
                     /db_xref="GeneID:80168"
                     /db_xref="HGNC:HGNC:23248"
                     /db_xref="MIM:610270"
ORIGIN      
        1 mkdyfpislv ktaeldpsrn yiagfhphgv lavgafanlc testgfssif pgirphlmml
       61 tlwfrapffr dyimsaglvt sekesaahil nrkgggnllg iivggaqeal darpgsftll
      121 lrnrkgfvrl althgaplvp ifsfgendlf dqipnssgsw lryiqnrlqk imgislplfh
      181 grgvfqysfg lipyrrpitt vellpeerte elpsqpgrtr erdelgpswf fpgmreatag
      241 qrggvegkee lpgl
//
LOCUS       XP_054226014             142 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 134 isoform X1 [Homo sapiens].
ACCESSION   XP_054226014
VERSION     XP_054226014.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370039.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..142
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..142
                     /product="transmembrane protein 134 isoform X1"
                     /calculated_mol_wt=15581
     Region          57..>128
                     /region_name="TMEM_230_134"
                     /note="Transmembrane proteins 230/134; pfam05915"
                     /db_xref="CDD:399128"
     CDS             1..142
                     /gene="TMEM134"
                     /coded_by="XM_054370039.1:60..488"
                     /db_xref="GeneID:80194"
                     /db_xref="HGNC:HGNC:26142"
ORIGIN      
        1 msaarpqfsi ddafelsled ggpgpessgv arfgplhfer rarfevaded kqsrlryqnl
       61 endedgaqas pepdggvgtr dssrtsirss qwsfstisss tqrsyntccs wtqhpliqkn
      121 rrvvlasfll lllglgeete al
//
LOCUS       XP_054226015             425 aa            linear   PRI 05-AUG-2025
DEFINITION  structure-specific endonuclease subunit MUS81 isoform X3 [Homo
            sapiens].
ACCESSION   XP_054226015
VERSION     XP_054226015.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370040.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..425
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..425
                     /product="structure-specific endonuclease subunit MUS81
                     isoform X3"
                     /calculated_mol_wt=47450
     Region          130..219
                     /region_name="WH_MUS81"
                     /note="winged helix domain found in crossover junction
                     endonuclease MUS81 and similar proteins; cd21036"
                     /db_xref="CDD:411029"
     Site            184..191
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:411029"
     Region          266..420
                     /region_name="XPF_nuclease_Mus81"
                     /note="XPF-like nuclease domain of Mus81; cd20074"
                     /db_xref="CDD:410850"
     Site            order(274,277,307)
                     /site_type="other"
                     /note="Mg binding site [ion binding]"
                     /db_xref="CDD:410850"
     Site            order(331,348,351..352,355,364,366,386..387,390..391,
                     393..394,398..402,404,408,412,415..416,419..420)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:410850"
     Site            order(345..346,351,384,387..388,391)
                     /site_type="other"
                     /note="nucleic acid substrate binding site [nucleotide
                     binding]"
                     /db_xref="CDD:410850"
     CDS             1..425
                     /gene="MUS81"
                     /gene_synonym="SLX3"
                     /coded_by="XM_054370040.1:1..1278"
                     /db_xref="GeneID:80198"
                     /db_xref="HGNC:HGNC:29814"
                     /db_xref="MIM:606591"
ORIGIN      
        1 maapvrlgrk rplpacpnpl fvrwltewrd eatrsrhrtr fvfqkalrsl rryplplrsg
       61 keakilqhfg dglcrmlder lqrhrtsggd hapdspsgen spapqgrlae vqdssmpvpa
      121 qpkaggsgsy wparhsgarv illvlyrehl npnghhfltk eellqrcaqk sprvapgsap
      181 pwpalrsllh rnlvlrthqp arysltpegl elaqklaese glsllnvgig pkeppgeeta
      241 vpgaasaela seagvqqqpl elrpgeyrvl lcvdigetrg gghrpellre lqrlhvthtv
      301 rklhvgdfvw vaqetnprdp aanpgelvld hiverkrldd lcssiidgrf reqkfrlkrc
      361 glerrvylve ehgsvhnlsl pestllqavt ntqvidgffv krtadikesa aylalltrgl
      421 qrlyq
//
LOCUS       XP_054226016             424 aa            linear   PRI 05-AUG-2025
DEFINITION  structure-specific endonuclease subunit MUS81 isoform X4 [Homo
            sapiens].
ACCESSION   XP_054226016
VERSION     XP_054226016.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370041.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..424
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..424
                     /product="structure-specific endonuclease subunit MUS81
                     isoform X4"
                     /calculated_mol_wt=47379
     Region          130..219
                     /region_name="WH_MUS81"
                     /note="winged helix domain found in crossover junction
                     endonuclease MUS81 and similar proteins; cd21036"
                     /db_xref="CDD:411029"
     Site            184..191
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:411029"
     Region          266..419
                     /region_name="XPF_nuclease_Mus81"
                     /note="XPF-like nuclease domain of Mus81; cd20074"
                     /db_xref="CDD:410850"
     Site            order(274,277,307)
                     /site_type="other"
                     /note="Mg binding site [ion binding]"
                     /db_xref="CDD:410850"
     Site            order(330,347,350..351,354,363,365,385..386,389..390,
                     392..393,397..401,403,407,411,414..415,418..419)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:410850"
     Site            order(344..345,350,383,386..387,390)
                     /site_type="other"
                     /note="nucleic acid substrate binding site [nucleotide
                     binding]"
                     /db_xref="CDD:410850"
     CDS             1..424
                     /gene="MUS81"
                     /gene_synonym="SLX3"
                     /coded_by="XM_054370041.1:322..1596"
                     /db_xref="GeneID:80198"
                     /db_xref="HGNC:HGNC:29814"
                     /db_xref="MIM:606591"
ORIGIN      
        1 maapvrlgrk rplpacpnpl fvrwltewrd eatrsrhrtr fvfqkalrsl rryplplrsg
       61 keakilqhfg dglcrmlder lqrhrtsggd hapdspsgen spapqgrlae vqdssmpvpa
      121 qpkaggsgsy wparhsgarv illvlyrehl npnghhfltk eellqrcaqk sprvapgsap
      181 pwpalrsllh rnlvlrthqp arysltpegl elaqklaese glsllnvgig pkeppgeeta
      241 vpgaasaela seagvqqqpl elrpgeyrvl lcvdigetrg gghrpellre lqrlhvthtv
      301 rklhvgdfvw vaqetnprdp anpgelvldh iverkrlddl cssiidgrfr eqkfrlkrcg
      361 lerrvylvee hgsvhnlslp estllqavtn tqvidgffvk rtadikesaa ylalltrglq
      421 rlyq
//
LOCUS       XP_054226017             324 aa            linear   PRI 05-AUG-2025
DEFINITION  structure-specific endonuclease subunit MUS81 isoform X5 [Homo
            sapiens].
ACCESSION   XP_054226017
VERSION     XP_054226017.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370042.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..324
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..324
                     /product="structure-specific endonuclease subunit MUS81
                     isoform X5"
                     /calculated_mol_wt=35191
     Region          34..>85
                     /region_name="NT_Pol-beta-like"
                     /note="Nucleotidyltransferase (NT) domain of DNA
                     polymerase beta and similar proteins; cl11966"
                     /db_xref="CDD:472251"
     Region          130..219
                     /region_name="WH_MUS81"
                     /note="winged helix domain found in crossover junction
                     endonuclease MUS81 and similar proteins; cd21036"
                     /db_xref="CDD:411029"
     Site            184..191
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:411029"
     CDS             1..324
                     /gene="MUS81"
                     /gene_synonym="SLX3"
                     /coded_by="XM_054370042.1:1..975"
                     /db_xref="GeneID:80198"
                     /db_xref="HGNC:HGNC:29814"
                     /db_xref="MIM:606591"
ORIGIN      
        1 maapvrlgrk rplpacpnpl fvrwltewrd eatrsrhrtr fvfqkalrsl rryplplrsg
       61 keakilqhfg dglcrmlder lqrhrtsggd hapdspsgen spapqgrlae vqdssmpvpa
      121 qpkaggsgsy wparhsgarv illvlyrehl npnghhfltk eellqrcaqk sprvapgsap
      181 pwpalrsllh rnlvlrthqp arysltpegl elaqklaese glsllnvgig pkeppgeeta
      241 vpgaasaela seagvqqqpl elrpgeyrvl lcvdigetrg lpslplqgra qagaaprata
      301 aardphgaqa arwrfcvggs gdqs
//
LOCUS       XP_054226018             324 aa            linear   PRI 05-AUG-2025
DEFINITION  structure-specific endonuclease subunit MUS81 isoform X5 [Homo
            sapiens].
ACCESSION   XP_054226018
VERSION     XP_054226018.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370043.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..324
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..324
                     /product="structure-specific endonuclease subunit MUS81
                     isoform X5"
                     /calculated_mol_wt=35191
     Region          34..>85
                     /region_name="NT_Pol-beta-like"
                     /note="Nucleotidyltransferase (NT) domain of DNA
                     polymerase beta and similar proteins; cl11966"
                     /db_xref="CDD:472251"
     Region          130..219
                     /region_name="WH_MUS81"
                     /note="winged helix domain found in crossover junction
                     endonuclease MUS81 and similar proteins; cd21036"
                     /db_xref="CDD:411029"
     Site            184..191
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:411029"
     CDS             1..324
                     /gene="MUS81"
                     /gene_synonym="SLX3"
                     /coded_by="XM_054370043.1:1..975"
                     /db_xref="GeneID:80198"
                     /db_xref="HGNC:HGNC:29814"
                     /db_xref="MIM:606591"
ORIGIN      
        1 maapvrlgrk rplpacpnpl fvrwltewrd eatrsrhrtr fvfqkalrsl rryplplrsg
       61 keakilqhfg dglcrmlder lqrhrtsggd hapdspsgen spapqgrlae vqdssmpvpa
      121 qpkaggsgsy wparhsgarv illvlyrehl npnghhfltk eellqrcaqk sprvapgsap
      181 pwpalrsllh rnlvlrthqp arysltpegl elaqklaese glsllnvgig pkeppgeeta
      241 vpgaasaela seagvqqqpl elrpgeyrvl lcvdigetrg lpslplqgra qagaaprata
      301 aardphgaqa arwrfcvggs gdqs
//
LOCUS       XP_054226019             350 aa            linear   PRI 05-AUG-2025
DEFINITION  proteasomal ATPase-associated factor 1 isoform X1 [Homo sapiens].
ACCESSION   XP_054226019
VERSION     XP_054226019.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370044.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..350
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..350
                     /product="proteasomal ATPase-associated factor 1 isoform
                     X1"
                     /calculated_mol_wt=37230
     Region          89..338
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Site            order(91,109,113,119..120,132..133,151,155,161..162,
                     174..175,192,197,203..204,217,230,236..237,256,260,
                     266..267,279,295,300,306..307,320..321,338)
                     /site_type="active"
                     /note="structural tetrad [active]"
                     /db_xref="CDD:238121"
     Region          95..132
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          138..174
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          179..222
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          231..278
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          283..317
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..350
                     /gene="PAAF1"
                     /gene_synonym="PAAF; Rpn14; WDR71"
                     /coded_by="XM_054370044.1:24..1076"
                     /db_xref="GeneID:80227"
                     /db_xref="HGNC:HGNC:25687"
                     /db_xref="MIM:619772"
ORIGIN      
        1 maaplriqsd waqalrkdeg eawlschppg kpslygsltc qgigldgipe vtasegftvn
       61 einkksihis cpkenasskf lapyttfsri htksitcldi ssrgglgvss stdgtmkiwq
      121 asngelrrvl eghvfdvncc rffpsglvvl sggmdaqlki wsaedascvv tfkghkggil
      181 dtaivdrgrn vvsasrdgta rlwdcgrsac lgvladcgss ingvavgaad nsinlgspeq
      241 mpserevgte akmlllared kklqclglqs rqlvflfigs dafncctfls gflllagtqd
      301 gniyqldvrs prapvqvihr sgapvlslls vrdgfiasqe fssmpttllp
//
LOCUS       XP_054226020             742 aa            linear   PRI 05-AUG-2025
DEFINITION  cullin-5 isoform X1 [Homo sapiens].
ACCESSION   XP_054226020
VERSION     XP_054226020.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370045.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..742
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..742
                     /product="cullin-5 isoform X1"
                     /calculated_mol_wt=86131
     Region          19..672
                     /region_name="Cullin"
                     /note="Cullin family; pfam00888"
                     /db_xref="CDD:459983"
     CDS             1..742
                     /gene="CUL5"
                     /gene_synonym="CUL-5; VACM-1; VACM1"
                     /coded_by="XM_054370045.1:452..2680"
                     /db_xref="GeneID:8065"
                     /db_xref="HGNC:HGNC:2556"
                     /db_xref="MIM:601741"
ORIGIN      
        1 matsnllknk gslqfedkwd fmrpivlkll rqesvtkqqw fdlfsdvhav clwddkgpak
       61 ihqalkedil efikqaqarv lshqddtall kayivewrkf ftqcdilpkp fcqleitlmg
      121 kqgsnkksnv edsivrklml dtwnesifsn iknrlqdsam klvhaerlge afdsqlvigv
      181 resyvnlcsn pedklqiyrd nfekayldst erfyrtqaps ylqqngvqny mkyadaklke
      241 eekralryle trrecnsvea lmeccvnalv tsfketilae cqgmikrnet eklhlmfslm
      301 dkvpngiepm lkdleehiis agladmvaaa etittdseky veqlltlfnr fsklvkeafq
      361 ddprfltard kaykavvnda tifklelplk qkgvglktqp eskcpellan ycdmllrktp
      421 lskkltseei eaklkevllv lkyvqnkdvf mryhkahltr rlildisads eieenmvewl
      481 revgmpadyv nklarmfqdi kvsedlnqaf kemhknnkla lpadsvniki lnagawsrss
      541 ekvfvslpte ledlipevee fykknhsgrk lhwhhlmsng iitfknevgq ydlevttfql
      601 avlfawnqrp rekisfenlk latelpdael rrtlwslvaf pklkrqvlly epqvnspkdf
      661 tegtlfsvnq efsliknakv qkrgkinlig rlqlttermr eeenegivql rilrtqiiqh
      721 wriclsqykn akggnrkncr pf
//
LOCUS       XP_054226021             721 aa            linear   PRI 05-AUG-2025
DEFINITION  cullin-5 isoform X2 [Homo sapiens].
ACCESSION   XP_054226021
VERSION     XP_054226021.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370046.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..721
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..721
                     /product="cullin-5 isoform X2"
                     /calculated_mol_wt=83975
     Region          19..613
                     /region_name="Cullin"
                     /note="Cullin family; pfam00888"
                     /db_xref="CDD:459983"
     Region          652..713
                     /region_name="Cullin_Nedd8"
                     /note="Cullin protein neddylation domain; pfam10557"
                     /db_xref="CDD:463146"
     CDS             1..721
                     /gene="CUL5"
                     /gene_synonym="CUL-5; VACM-1; VACM1"
                     /coded_by="XM_054370046.1:452..2617"
                     /db_xref="GeneID:8065"
                     /db_xref="HGNC:HGNC:2556"
                     /db_xref="MIM:601741"
ORIGIN      
        1 matsnllknk gslqfedkwd fmrpivlkll rqesvtkqqw fdlfsdvhav clwddkgpak
       61 ihqalkedil efikqaqalm ldtwnesifs niknrlqdsa mklvhaerlg eafdsqlvig
      121 vresyvnlcs npedklqiyr dnfekaylds terfyrtqap sylqqngvqn ymkyadaklk
      181 eeekralryl etrrecnsve almeccvnal vtsfketila ecqgmikrne teklhlmfsl
      241 mdkvpngiep mlkdleehii sagladmvaa aetittdsek yveqlltlfn rfsklvkeaf
      301 qddprfltar dkaykavvnd atifklelpl kqkgvglktq peskcpella nycdmllrkt
      361 plskkltsee ieaklkevll vlkyvqnkdv fmryhkahlt rrlildisad seieenmvew
      421 lrevgmpady vnklarmfqd ikvsedlnqa fkemhknnkl alpadsvnik ilnagawsrs
      481 sekvfvslpt eledlipeve efykknhsgr klhwhhlmsn giitfknevg qydlevttfq
      541 lavlfawnqr prekisfenl klatelpdae lrrtlwslva fpklkrqvll yepqvnspkd
      601 ftegtlfsvn qefsliknak vqkrgkinli grlqltterm reeenegivq lrilrtqeai
      661 iqimkmrkki snaqlqtelv eilknmflpq kkmikeqiew liehkyirrd esdintfiym
      721 a
//
LOCUS       XP_054226022             683 aa            linear   PRI 05-AUG-2025
DEFINITION  cullin-5 isoform X3 [Homo sapiens].
ACCESSION   XP_054226022
VERSION     XP_054226022.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370047.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..683
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..683
                     /product="cullin-5 isoform X3"
                     /calculated_mol_wt=79281
     Region          19..613
                     /region_name="Cullin"
                     /note="Cullin family; pfam00888"
                     /db_xref="CDD:459983"
     CDS             1..683
                     /gene="CUL5"
                     /gene_synonym="CUL-5; VACM-1; VACM1"
                     /coded_by="XM_054370047.1:452..2503"
                     /db_xref="GeneID:8065"
                     /db_xref="HGNC:HGNC:2556"
                     /db_xref="MIM:601741"
ORIGIN      
        1 matsnllknk gslqfedkwd fmrpivlkll rqesvtkqqw fdlfsdvhav clwddkgpak
       61 ihqalkedil efikqaqalm ldtwnesifs niknrlqdsa mklvhaerlg eafdsqlvig
      121 vresyvnlcs npedklqiyr dnfekaylds terfyrtqap sylqqngvqn ymkyadaklk
      181 eeekralryl etrrecnsve almeccvnal vtsfketila ecqgmikrne teklhlmfsl
      241 mdkvpngiep mlkdleehii sagladmvaa aetittdsek yveqlltlfn rfsklvkeaf
      301 qddprfltar dkaykavvnd atifklelpl kqkgvglktq peskcpella nycdmllrkt
      361 plskkltsee ieaklkevll vlkyvqnkdv fmryhkahlt rrlildisad seieenmvew
      421 lrevgmpady vnklarmfqd ikvsedlnqa fkemhknnkl alpadsvnik ilnagawsrs
      481 sekvfvslpt eledlipeve efykknhsgr klhwhhlmsn giitfknevg qydlevttfq
      541 lavlfawnqr prekisfenl klatelpdae lrrtlwslva fpklkrqvll yepqvnspkd
      601 ftegtlfsvn qefsliknak vqkrgkinli grlqltterm reeenegivq lrilrtqiiq
      661 hwriclsqyk nakggnrknc rpf
//
LOCUS       XP_054226023             519 aa            linear   PRI 05-AUG-2025
DEFINITION  cullin-5 isoform X4 [Homo sapiens].
ACCESSION   XP_054226023
VERSION     XP_054226023.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370048.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..519
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..519
                     /product="cullin-5 isoform X4"
                     /calculated_mol_wt=60223
     Region          <1..411
                     /region_name="Cullin"
                     /note="Cullin family; pfam00888"
                     /db_xref="CDD:459983"
     Region          450..511
                     /region_name="Cullin_Nedd8"
                     /note="Cullin protein neddylation domain; pfam10557"
                     /db_xref="CDD:463146"
     CDS             1..519
                     /gene="CUL5"
                     /gene_synonym="CUL-5; VACM-1; VACM1"
                     /coded_by="XM_054370048.1:94..1653"
                     /db_xref="GeneID:8065"
                     /db_xref="HGNC:HGNC:2556"
                     /db_xref="MIM:601741"
ORIGIN      
        1 meccvnalvt sfketilaec qgmikrnete klhlmfslmd kvpngiepml kdleehiisa
       61 gladmvaaae tittdsekyv eqlltlfnrf sklvkeafqd dprfltardk aykavvndat
      121 ifklelplkq kgvglktqpe skcpellany cdmllrktpl skkltseeie aklkevllvl
      181 kyvqnkdvfm ryhkahltrr lildisadse ieenmvewlr evgmpadyvn klarmfqdik
      241 vsedlnqafk emhknnklal padsvnikil nagawsrsse kvfvslptel edlipeveef
      301 ykknhsgrkl hwhhlmsngi itfknevgqy dlevttfqla vlfawnqrpr ekisfenlkl
      361 atelpdaelr rtlwslvafp klkrqvllye pqvnspkdft egtlfsvnqe fsliknakvq
      421 krgkinligr lqlttermre eenegivqlr ilrtqeaiiq imkmrkkisn aqlqtelvei
      481 lknmflpqkk mikeqiewli ehkyirrdes dintfiyma
//
LOCUS       XP_054226024             396 aa            linear   PRI 05-AUG-2025
DEFINITION  cullin-5 isoform X5 [Homo sapiens].
ACCESSION   XP_054226024
VERSION     XP_054226024.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370049.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..396
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..396
                     /product="cullin-5 isoform X5"
                     /calculated_mol_wt=45910
     Region          19..>371
                     /region_name="Cullin"
                     /note="Cullin family; pfam00888"
                     /db_xref="CDD:459983"
     CDS             1..396
                     /gene="CUL5"
                     /gene_synonym="CUL-5; VACM-1; VACM1"
                     /coded_by="XM_054370049.1:452..1642"
                     /db_xref="GeneID:8065"
                     /db_xref="HGNC:HGNC:2556"
                     /db_xref="MIM:601741"
ORIGIN      
        1 matsnllknk gslqfedkwd fmrpivlkll rqesvtkqqw fdlfsdvhav clwddkgpak
       61 ihqalkedil efikqaqarv lshqddtall kayivewrkf ftqcdilpkp fcqleitlmg
      121 kqgsnkksnv edsivrklml dtwnesifsn iknrlqdsam klvhaerlge afdsqlvigv
      181 resyvnlcsn pedklqiyrd nfekayldst erfyrtqaps ylqqngvqny mkyadaklke
      241 eekralryle trrecnsvea lmeccvnalv tsfketilae cqgmikrnet eklhlmfslm
      301 dkvpngiepm lkdleehiis agladmvaaa etittdseky veqlltlfnr fsklvkeafq
      361 ddprfltard ktqlkeyfpw sfldvlppst ahhqqs
//
LOCUS       XP_054226025             257 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protease serine 5 isoform X1 [Homo sapiens].
ACCESSION   XP_054226025
VERSION     XP_054226025.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370050.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..257
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..257
                     /product="transmembrane protease serine 5 isoform X1"
                     /calculated_mol_wt=27876
     Region          72..169
                     /region_name="SRCR_2"
                     /note="Scavenger receptor cysteine-rich domain; pfam15494"
                     /db_xref="CDD:464747"
     Region          173..>218
                     /region_name="Tryp_SPc"
                     /note="Trypsin-like serine protease; Many of these are
                     synthesized as inactive precursor zymogens that are
                     cleaved during limited proteolysis to generate their
                     active forms. Alignment contains also inactive enzymes
                     that have substitutions of the catalytic triad...;
                     cl21584"
                     /db_xref="CDD:473915"
     Site            174
                     /site_type="active"
                     /note="cleavage site [active]"
                     /db_xref="CDD:238113"
     CDS             1..257
                     /gene="TMPRSS5"
                     /gene_synonym="SPINESIN"
                     /coded_by="XM_054370050.1:6267..7040"
                     /db_xref="GeneID:80975"
                     /db_xref="HGNC:HGNC:14908"
                     /db_xref="MIM:606751"
ORIGIN      
        1 mrrgcavlga lgllagagvg swllvlylcp aasqpisgtl qdeeitlscs easaeeallp
       61 alpktvsfri nsedflleaq vrdqprwllv chegwspalg lqicwslghl rlthhkgvnl
      121 tdiklnssqe faqlsprlgg fleeawqprn nctsgqvvsl rcsecgarpl asrivggqsv
      181 apgrwpwqas valgfrhtcg gsvlaprwvv taahcmhrqv svaaedrepq lpflfgcwyv
      241 lyqmfvsncl qlfapkg
//
LOCUS       XP_054226026             456 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protease serine 5 isoform X2 [Homo sapiens].
ACCESSION   XP_054226026
VERSION     XP_054226026.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370051.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..456
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..456
                     /product="transmembrane protease serine 5 isoform X2"
                     /calculated_mol_wt=49214
     Region          107..204
                     /region_name="SRCR_2"
                     /note="Scavenger receptor cysteine-rich domain; pfam15494"
                     /db_xref="CDD:464747"
     Region          208..439
                     /region_name="Tryp_SPc"
                     /note="Trypsin-like serine protease; smart00020"
                     /db_xref="CDD:214473"
     Site            209
                     /site_type="active"
                     /note="cleavage site [active]"
                     /db_xref="CDD:238113"
     Site            order(249,299,396)
                     /site_type="active"
                     /db_xref="CDD:238113"
     Site            order(390,415,417)
                     /site_type="other"
                     /note="substrate binding sites [chemical binding]"
                     /db_xref="CDD:238113"
     CDS             1..456
                     /gene="TMPRSS5"
                     /gene_synonym="SPINESIN"
                     /coded_by="XM_054370051.1:19..1389"
                     /db_xref="GeneID:80975"
                     /db_xref="HGNC:HGNC:14908"
                     /db_xref="MIM:606751"
ORIGIN      
        1 mtgwgqwrai ilhspdppwg qphmidvsqa vcwrsmrrgc avlgalglla gagvgswllv
       61 lylcpaasqp isgtlqdeei tlscseasae eallpalpkt vsfrinsedf lleaqvrdqp
      121 rwllvchegw spalglqicw slghlrlthh kgvnltdikl nssqefaqls prlggfleea
      181 wqprnnctsg qvvslrcsec garplasriv ggqsvapgrw pwqasvalgf rhtcggsvla
      241 prwvvtaahc mhsfrlarls swrvhaglvs hsavrphqga lveriiphpl ysaqnhdydv
      301 allrlqtaln fsdtvgavcl pakeqhfpkg srcwvsgwgh thpshtyssd mlqdtvvpll
      361 stqlcnsscv ysgaltprml cagyldgrad acqgdsggpl vcpdgdtwrl vgvvswgrgc
      421 aepnhpgvya kvaefldwih dtaqvsvgag vgqgdf
//
LOCUS       XP_054226027             503 aa            linear   PRI 05-AUG-2025
DEFINITION  phosphatidylserine synthase 2 isoform X1 [Homo sapiens].
ACCESSION   XP_054226027
VERSION     XP_054226027.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370052.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..503
                     /product="phosphatidylserine synthase 2 isoform X1"
                     /calculated_mol_wt=57679
     Region          120..416
                     /region_name="PSS"
                     /note="Phosphatidyl serine synthase; pfam03034"
                     /db_xref="CDD:460783"
     CDS             1..503
                     /gene="PTDSS2"
                     /gene_synonym="PSS2"
                     /coded_by="XM_054370052.1:1040..2551"
                     /db_xref="GeneID:81490"
                     /db_xref="HGNC:HGNC:15463"
                     /db_xref="MIM:612793"
ORIGIN      
        1 mrrgerrdag gprpespvpa grasleeppd gpsagqatgp gegrrstese vyddgtntff
       61 wrahtltvlf iltctlgyvt lleetpqdta yntkrgivas ilvflcfgvt qakdgpfsrp
      121 hpaywrfwlc vsvvyelfli filfqlpplt vapltgalal qtvqdgrqfl kyvdpklgvp
      181 lperdyggnc liydpdnetd pfhniwdkld gfvpahflgw ylktlmirdw wmcmiisvmf
      241 efleyslehq lpnfsecwwd hwimdvlvcn glgiycgmkt lewlslktyk wqglwnipty
      301 kgkmkriafq ftpyswvrfe wkpasslrrw lavcgiilvf llaelntfyl kfvlwmppeh
      361 ylvllrlvff vnvggvamre iydfmddpkp hkklgpqawl vaaitatell ivvkydphtl
      421 tlslpfyisq cwtlgsvlal twtvwrfflr ditlryketr wqkwqnkddq gstvgngdqh
      481 plgldedllg pgvaegegap tpn
//
LOCUS       XP_054226028             459 aa            linear   PRI 05-AUG-2025
DEFINITION  phosphatidylserine synthase 2 isoform X2 [Homo sapiens].
ACCESSION   XP_054226028
VERSION     XP_054226028.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370053.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..459
                     /product="phosphatidylserine synthase 2 isoform X2"
                     /calculated_mol_wt=53033
     Region          92..372
                     /region_name="PSS"
                     /note="Phosphatidyl serine synthase; pfam03034"
                     /db_xref="CDD:460783"
     CDS             1..459
                     /gene="PTDSS2"
                     /gene_synonym="PSS2"
                     /coded_by="XM_054370053.1:982..2361"
                     /db_xref="GeneID:81490"
                     /db_xref="HGNC:HGNC:15463"
                     /db_xref="MIM:612793"
ORIGIN      
        1 mcwlgaecgr sqgahaslrs ppstreagaa aqrrahtltv lfiltctlgy vtlleetpqd
       61 tayntkrgiv asilvflcfg vtqakdgpfs rphpaywrfw lcvsvvyelf lifilfqtvq
      121 dgrqflkyvd pklgvplper dyggncliyd pdnetdpfhn iwdkldgfvp ahflgwylkt
      181 lmirdwwmcm iisvmfefle yslehqlpnf secwwdhwim dvlvcnglgi ycgmktlewl
      241 slktykwqgl wniptykgkm kriafqftpy swvrfewkpa sslrrwlavc giilvfllae
      301 lntfylkfvl wmppehylvl lrlvffvnvg gvamreiydf mddpkphkkl gpqawlvaai
      361 tatellivvk ydphtltlsl pfyisqcwtl gsvlaltwtv wrfflrditl ryketrwqkw
      421 qnkddqgstv gngdqhplgl dedllgpgva egegaptpn
//
LOCUS       XP_054226029             443 aa            linear   PRI 05-AUG-2025
DEFINITION  phosphatidylserine synthase 2 isoform X3 [Homo sapiens].
ACCESSION   XP_054226029
VERSION     XP_054226029.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370054.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..443
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..443
                     /product="phosphatidylserine synthase 2 isoform X3"
                     /calculated_mol_wt=51325
     Region          60..356
                     /region_name="PSS"
                     /note="Phosphatidyl serine synthase; pfam03034"
                     /db_xref="CDD:460783"
     CDS             1..443
                     /gene="PTDSS2"
                     /gene_synonym="PSS2"
                     /coded_by="XM_054370054.1:151..1482"
                     /db_xref="GeneID:81490"
                     /db_xref="HGNC:HGNC:15463"
                     /db_xref="MIM:612793"
ORIGIN      
        1 mrahtltvlf iltctlgyvt lleetpqdta yntkrgivas ilvflcfgvt qakdgpfsrp
       61 hpaywrfwlc vsvvyelfli filfqlpplt vapltgalal qtvqdgrqfl kyvdpklgvp
      121 lperdyggnc liydpdnetd pfhniwdkld gfvpahflgw ylktlmirdw wmcmiisvmf
      181 efleyslehq lpnfsecwwd hwimdvlvcn glgiycgmkt lewlslktyk wqglwnipty
      241 kgkmkriafq ftpyswvrfe wkpasslrrw lavcgiilvf llaelntfyl kfvlwmppeh
      301 ylvllrlvff vnvggvamre iydfmddpkp hkklgpqawl vaaitatell ivvkydphtl
      361 tlslpfyisq cwtlgsvlal twtvwrfflr ditlryketr wqkwqnkddq gstvgngdqh
      421 plgldedllg pgvaegegap tpn
//
LOCUS       XP_054226030             241 aa            linear   PRI 05-AUG-2025
DEFINITION  MOB kinase activator 2 isoform X8 [Homo sapiens].
ACCESSION   XP_054226030
VERSION     XP_054226030.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370055.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..241
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..241
                     /product="MOB kinase activator 2 isoform X8"
                     /calculated_mol_wt=27220
     Region          36..204
                     /region_name="Mob1_phocein"
                     /note="Mob1/phocein family; pfam03637"
                     /db_xref="CDD:461000"
     CDS             1..241
                     /gene="MOB2"
                     /gene_synonym="HCCA2"
                     /coded_by="XM_054370055.1:10..735"
                     /db_xref="GeneID:81532"
                     /db_xref="HGNC:HGNC:24904"
                     /db_xref="MIM:611969"
ORIGIN      
        1 mgmsdpvqrr kskakpngkk paaeerkayl epehtkarit dfqfkelvvl preidlnewl
       61 asntttffhh inlqystise fctgetcqtm avcntqyywy dergkkvkct apqyvdfvms
      121 svqklvtded vfptkygref pssfeslvrk icrhlfhvla hiywahfket lalelhghln
      181 tlyvhfilfa refnlldpke taimddltev lcsgaggvhs ggsgdgagsg gpgaqnhvke
      241 r
//
LOCUS       XP_054226031             232 aa            linear   PRI 05-AUG-2025
DEFINITION  MOB kinase activator 2 isoform X9 [Homo sapiens].
ACCESSION   XP_054226031
VERSION     XP_054226031.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370056.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..232
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..232
                     /product="MOB kinase activator 2 isoform X9"
                     /calculated_mol_wt=26193
     Region          27..195
                     /region_name="Mob1_phocein"
                     /note="Mob1/phocein family; pfam03637"
                     /db_xref="CDD:461000"
     CDS             1..232
                     /gene="MOB2"
                     /gene_synonym="HCCA2"
                     /coded_by="XM_054370056.1:587..1285"
                     /db_xref="GeneID:81532"
                     /db_xref="HGNC:HGNC:24904"
                     /db_xref="MIM:611969"
ORIGIN      
        1 mkskakpngk kpaaeerkay lepehtkari tdfqfkelvv lpreidlnew lasntttffh
       61 hinlqystis efctgetcqt mavcntqyyw ydergkkvkc tapqyvdfvm ssvqklvtde
      121 dvfptkygre fpssfeslvr kicrhlfhvl ahiywahfke tlalelhghl ntlyvhfilf
      181 arefnlldpk etaimddlte vlcsgaggvh sggsgdgags ggpgaqnhvk er
//
LOCUS       XP_054226032             173 aa            linear   PRI 05-AUG-2025
DEFINITION  MOB kinase activator 2 isoform X10 [Homo sapiens].
ACCESSION   XP_054226032
VERSION     XP_054226032.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370057.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..173
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..173
                     /product="MOB kinase activator 2 isoform X10"
                     /calculated_mol_wt=19600
     Region          63..>169
                     /region_name="Mob1_phocein"
                     /note="Mob1/phocein family; pfam03637"
                     /db_xref="CDD:461000"
     CDS             1..173
                     /gene="MOB2"
                     /gene_synonym="HCCA2"
                     /coded_by="XM_054370057.1:224..745"
                     /db_xref="GeneID:81532"
                     /db_xref="HGNC:HGNC:24904"
                     /db_xref="MIM:611969"
ORIGIN      
        1 mlgdhcslpe dqarpgqspq sglcckmvlq avskvlrksk akpngkkpaa eerkaylepe
       61 htkaritdfq fkelvvlpre idlnewlasn tttffhhinl qystisefct getcqtmavc
      121 ntqyywyder gkkvkctapq yvdfvmssvq klvtdedvfp tkyenspapl spw
//
LOCUS       XP_054226033             152 aa            linear   PRI 05-AUG-2025
DEFINITION  MOB kinase activator 2 isoform X11 [Homo sapiens].
ACCESSION   XP_054226033
VERSION     XP_054226033.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370058.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..152
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..152
                     /product="MOB kinase activator 2 isoform X11"
                     /calculated_mol_wt=16951
     Region          <5..115
                     /region_name="Mob1_phocein"
                     /note="Mob1/phocein family; pfam03637"
                     /db_xref="CDD:461000"
     CDS             1..152
                     /gene="MOB2"
                     /gene_synonym="HCCA2"
                     /coded_by="XM_054370058.1:387..845"
                     /db_xref="GeneID:81532"
                     /db_xref="HGNC:HGNC:24904"
                     /db_xref="MIM:611969"
ORIGIN      
        1 mavcntqyyw ydergkkvkc tapqyvdfvm ssvqklvtde dvfptkygre fpssfeslvr
       61 kicrhlfhvl ahiywahfke tlalelhghl ntlyvhfilf arefnlldpk etaimddlte
      121 vlcsgaggvh sggsgdgags ggpgaqnhvk er
//
LOCUS       XP_054226034             142 aa            linear   PRI 05-AUG-2025
DEFINITION  MOB kinase activator 2 isoform X12 [Homo sapiens].
ACCESSION   XP_054226034
VERSION     XP_054226034.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370059.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 5% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..142
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..142
                     /product="MOB kinase activator 2 isoform X12"
                     /calculated_mol_wt=16369
     Region          32..>138
                     /region_name="Mob1_phocein"
                     /note="Mob1/phocein family; pfam03637"
                     /db_xref="CDD:461000"
     CDS             1..142
                     /gene="MOB2"
                     /gene_synonym="HCCA2"
                     /coded_by="XM_054370059.1:104..532"
                     /db_xref="GeneID:81532"
                     /db_xref="HGNC:HGNC:24904"
                     /db_xref="MIM:611969"
ORIGIN      
        1 mdwlmgkska kpngkkpaae erkaylepeh tkaritdfqf kelvvlprei dlnewlasnt
       61 ttffhhinlq ystisefctg etcqtmavcn tqyywyderg kkvkctapqy vdfvmssvqk
      121 lvtdedvfpt kyenspapls pw
//
LOCUS       XP_054226035             137 aa            linear   PRI 05-AUG-2025
DEFINITION  MOB kinase activator 2 isoform X13 [Homo sapiens].
ACCESSION   XP_054226035
VERSION     XP_054226035.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370060.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..137
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..137
                     /product="MOB kinase activator 2 isoform X13"
                     /calculated_mol_wt=15766
     Region          27..>133
                     /region_name="Mob1_phocein"
                     /note="Mob1/phocein family; pfam03637"
                     /db_xref="CDD:461000"
     CDS             1..137
                     /gene="MOB2"
                     /gene_synonym="HCCA2"
                     /coded_by="XM_054370060.1:592..1005"
                     /db_xref="GeneID:81532"
                     /db_xref="HGNC:HGNC:24904"
                     /db_xref="MIM:611969"
ORIGIN      
        1 mkskakpngk kpaaeerkay lepehtkari tdfqfkelvv lpreidlnew lasntttffh
       61 hinlqystis efctgetcqt mavcntqyyw ydergkkvkc tapqyvdfvm ssvqklvtde
      121 dvfptkyens paplspw
//
LOCUS       XP_054226036             606 aa            linear   PRI 05-AUG-2025
DEFINITION  glycerophosphodiester phosphodiesterase domain-containing protein 5
            isoform X1 [Homo sapiens].
ACCESSION   XP_054226036
VERSION     XP_054226036.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370061.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..606
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..606
                     /product="glycerophosphodiester phosphodiesterase
                     domain-containing protein 5 isoform X1"
                     /calculated_mol_wt=68526
     Region          227..577
                     /region_name="GDPD_GDE2"
                     /note="Glycerophosphodiester phosphodiesterase domain of
                     mammalian glycerophosphodiester phosphodiesterase GDE2 and
                     similar proteins; cd08608"
                     /db_xref="CDD:176550"
     Site            order(233,260,262,275,358,394,454)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:176550"
     Site            order(233,275)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:176550"
     Site            order(260,262,358)
                     /site_type="other"
                     /note="putative metal binding site [ion binding]"
                     /db_xref="CDD:176550"
     CDS             1..606
                     /gene="GDPD5"
                     /gene_synonym="GDE2; PP1665"
                     /coded_by="XM_054370061.1:881..2701"
                     /db_xref="GeneID:81544"
                     /db_xref="HGNC:HGNC:28804"
                     /db_xref="MIM:609632"
ORIGIN      
        1 mvrhqplqyy epqlclsclt giygcrwkry qrshddttpw erlwfllltf tfgltltwly
       61 fwwevhndyd efnwylynrm gywsdwpvpi lvttaaafay iagllvlalc hiavgqqmnl
      121 hwlhkiglvv ilastvvams avaqlwedew evllislqgt apflhvgava avtmlswiva
      181 gqfaraerts sqvtilctff tvvfalylap ltisspcime kkdlgpkpal ighrgapmla
      241 pehtlmsfrk aleqklyglq aditisldgv pflmhdttlr rttnveeefp elarrpasml
      301 nwttlqrlna gqwflktdpf wtasslspsd hreaqnqsic slaellelak gnatlllnlr
      361 dpprehpyrs sfinvtleav lhsgfpqhqv mwlpsrqrpl vrkvapgfqq tsgskeavas
      421 lrrghiqrln lrytqvsrqe lrdyaswnls vnlytvnapw lfsllwcagv psvtsdnsha
      481 lsqvpsplwi mppdeyclmw vtadlvsftl ivgifvlqkw rlggirsynp eqimlsaavr
      541 rtsrdvsimk eklifsaeis dgvevsdvls vcsdnsydty anstatpvgp rgggshtktl
      601 iersgr
//
LOCUS       XP_054226037             606 aa            linear   PRI 05-AUG-2025
DEFINITION  glycerophosphodiester phosphodiesterase domain-containing protein 5
            isoform X1 [Homo sapiens].
ACCESSION   XP_054226037
VERSION     XP_054226037.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370062.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 1% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..606
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..606
                     /product="glycerophosphodiester phosphodiesterase
                     domain-containing protein 5 isoform X1"
                     /calculated_mol_wt=68526
     Region          227..577
                     /region_name="GDPD_GDE2"
                     /note="Glycerophosphodiester phosphodiesterase domain of
                     mammalian glycerophosphodiester phosphodiesterase GDE2 and
                     similar proteins; cd08608"
                     /db_xref="CDD:176550"
     Site            order(233,260,262,275,358,394,454)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:176550"
     Site            order(233,275)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:176550"
     Site            order(260,262,358)
                     /site_type="other"
                     /note="putative metal binding site [ion binding]"
                     /db_xref="CDD:176550"
     CDS             1..606
                     /gene="GDPD5"
                     /gene_synonym="GDE2; PP1665"
                     /coded_by="XM_054370062.1:1358..3178"
                     /db_xref="GeneID:81544"
                     /db_xref="HGNC:HGNC:28804"
                     /db_xref="MIM:609632"
ORIGIN      
        1 mvrhqplqyy epqlclsclt giygcrwkry qrshddttpw erlwfllltf tfgltltwly
       61 fwwevhndyd efnwylynrm gywsdwpvpi lvttaaafay iagllvlalc hiavgqqmnl
      121 hwlhkiglvv ilastvvams avaqlwedew evllislqgt apflhvgava avtmlswiva
      181 gqfaraerts sqvtilctff tvvfalylap ltisspcime kkdlgpkpal ighrgapmla
      241 pehtlmsfrk aleqklyglq aditisldgv pflmhdttlr rttnveeefp elarrpasml
      301 nwttlqrlna gqwflktdpf wtasslspsd hreaqnqsic slaellelak gnatlllnlr
      361 dpprehpyrs sfinvtleav lhsgfpqhqv mwlpsrqrpl vrkvapgfqq tsgskeavas
      421 lrrghiqrln lrytqvsrqe lrdyaswnls vnlytvnapw lfsllwcagv psvtsdnsha
      481 lsqvpsplwi mppdeyclmw vtadlvsftl ivgifvlqkw rlggirsynp eqimlsaavr
      541 rtsrdvsimk eklifsaeis dgvevsdvls vcsdnsydty anstatpvgp rgggshtktl
      601 iersgr
//
LOCUS       XP_054226038             606 aa            linear   PRI 05-AUG-2025
DEFINITION  glycerophosphodiester phosphodiesterase domain-containing protein 5
            isoform X1 [Homo sapiens].
ACCESSION   XP_054226038
VERSION     XP_054226038.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370063.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..606
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..606
                     /product="glycerophosphodiester phosphodiesterase
                     domain-containing protein 5 isoform X1"
                     /calculated_mol_wt=68526
     Region          227..577
                     /region_name="GDPD_GDE2"
                     /note="Glycerophosphodiester phosphodiesterase domain of
                     mammalian glycerophosphodiester phosphodiesterase GDE2 and
                     similar proteins; cd08608"
                     /db_xref="CDD:176550"
     Site            order(233,260,262,275,358,394,454)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:176550"
     Site            order(233,275)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:176550"
     Site            order(260,262,358)
                     /site_type="other"
                     /note="putative metal binding site [ion binding]"
                     /db_xref="CDD:176550"
     CDS             1..606
                     /gene="GDPD5"
                     /gene_synonym="GDE2; PP1665"
                     /coded_by="XM_054370063.1:636..2456"
                     /db_xref="GeneID:81544"
                     /db_xref="HGNC:HGNC:28804"
                     /db_xref="MIM:609632"
ORIGIN      
        1 mvrhqplqyy epqlclsclt giygcrwkry qrshddttpw erlwfllltf tfgltltwly
       61 fwwevhndyd efnwylynrm gywsdwpvpi lvttaaafay iagllvlalc hiavgqqmnl
      121 hwlhkiglvv ilastvvams avaqlwedew evllislqgt apflhvgava avtmlswiva
      181 gqfaraerts sqvtilctff tvvfalylap ltisspcime kkdlgpkpal ighrgapmla
      241 pehtlmsfrk aleqklyglq aditisldgv pflmhdttlr rttnveeefp elarrpasml
      301 nwttlqrlna gqwflktdpf wtasslspsd hreaqnqsic slaellelak gnatlllnlr
      361 dpprehpyrs sfinvtleav lhsgfpqhqv mwlpsrqrpl vrkvapgfqq tsgskeavas
      421 lrrghiqrln lrytqvsrqe lrdyaswnls vnlytvnapw lfsllwcagv psvtsdnsha
      481 lsqvpsplwi mppdeyclmw vtadlvsftl ivgifvlqkw rlggirsynp eqimlsaavr
      541 rtsrdvsimk eklifsaeis dgvevsdvls vcsdnsydty anstatpvgp rgggshtktl
      601 iersgr
//
LOCUS       XP_054226039             606 aa            linear   PRI 05-AUG-2025
DEFINITION  glycerophosphodiester phosphodiesterase domain-containing protein 5
            isoform X1 [Homo sapiens].
ACCESSION   XP_054226039
VERSION     XP_054226039.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370064.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 1% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..606
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..606
                     /product="glycerophosphodiester phosphodiesterase
                     domain-containing protein 5 isoform X1"
                     /calculated_mol_wt=68526
     Region          227..577
                     /region_name="GDPD_GDE2"
                     /note="Glycerophosphodiester phosphodiesterase domain of
                     mammalian glycerophosphodiester phosphodiesterase GDE2 and
                     similar proteins; cd08608"
                     /db_xref="CDD:176550"
     Site            order(233,260,262,275,358,394,454)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:176550"
     Site            order(233,275)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:176550"
     Site            order(260,262,358)
                     /site_type="other"
                     /note="putative metal binding site [ion binding]"
                     /db_xref="CDD:176550"
     CDS             1..606
                     /gene="GDPD5"
                     /gene_synonym="GDE2; PP1665"
                     /coded_by="XM_054370064.1:1295..3115"
                     /db_xref="GeneID:81544"
                     /db_xref="HGNC:HGNC:28804"
                     /db_xref="MIM:609632"
ORIGIN      
        1 mvrhqplqyy epqlclsclt giygcrwkry qrshddttpw erlwfllltf tfgltltwly
       61 fwwevhndyd efnwylynrm gywsdwpvpi lvttaaafay iagllvlalc hiavgqqmnl
      121 hwlhkiglvv ilastvvams avaqlwedew evllislqgt apflhvgava avtmlswiva
      181 gqfaraerts sqvtilctff tvvfalylap ltisspcime kkdlgpkpal ighrgapmla
      241 pehtlmsfrk aleqklyglq aditisldgv pflmhdttlr rttnveeefp elarrpasml
      301 nwttlqrlna gqwflktdpf wtasslspsd hreaqnqsic slaellelak gnatlllnlr
      361 dpprehpyrs sfinvtleav lhsgfpqhqv mwlpsrqrpl vrkvapgfqq tsgskeavas
      421 lrrghiqrln lrytqvsrqe lrdyaswnls vnlytvnapw lfsllwcagv psvtsdnsha
      481 lsqvpsplwi mppdeyclmw vtadlvsftl ivgifvlqkw rlggirsynp eqimlsaavr
      541 rtsrdvsimk eklifsaeis dgvevsdvls vcsdnsydty anstatpvgp rgggshtktl
      601 iersgr
//
LOCUS       XP_054226040             605 aa            linear   PRI 05-AUG-2025
DEFINITION  glycerophosphodiester phosphodiesterase domain-containing protein 5
            isoform X2 [Homo sapiens].
ACCESSION   XP_054226040
VERSION     XP_054226040.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370065.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 1% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..605
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..605
                     /product="glycerophosphodiester phosphodiesterase
                     domain-containing protein 5 isoform X2"
                     /calculated_mol_wt=68455
     Region          227..576
                     /region_name="GDPD_GDE2"
                     /note="Glycerophosphodiester phosphodiesterase domain of
                     mammalian glycerophosphodiester phosphodiesterase GDE2 and
                     similar proteins; cd08608"
                     /db_xref="CDD:176550"
     Site            order(233,260,262,275,358,394,454)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:176550"
     Site            order(233,275)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:176550"
     Site            order(260,262,358)
                     /site_type="other"
                     /note="putative metal binding site [ion binding]"
                     /db_xref="CDD:176550"
     CDS             1..605
                     /gene="GDPD5"
                     /gene_synonym="GDE2; PP1665"
                     /coded_by="XM_054370065.1:1295..3112"
                     /db_xref="GeneID:81544"
                     /db_xref="HGNC:HGNC:28804"
                     /db_xref="MIM:609632"
ORIGIN      
        1 mvrhqplqyy epqlclsclt giygcrwkry qrshddttpw erlwfllltf tfgltltwly
       61 fwwevhndyd efnwylynrm gywsdwpvpi lvttaaafay iagllvlalc hiavgqqmnl
      121 hwlhkiglvv ilastvvams avaqlwedew evllislqgt apflhvgava avtmlswiva
      181 gqfaraerts sqvtilctff tvvfalylap ltisspcime kkdlgpkpal ighrgapmla
      241 pehtlmsfrk aleqklyglq aditisldgv pflmhdttlr rttnveeefp elarrpasml
      301 nwttlqrlna gqwflktdpf wtasslspsd hreaqnqsic slaellelak gnatlllnlr
      361 dpprehpyrs sfinvtleav lhsgfpqhqv mwlpsrqrpl vrkvapgfqq tsgskeavas
      421 lrrghiqrln lrytqvsrqe lrdyaswnls vnlytvnapw lfsllwcagv psvtsdnsha
      481 lsqvpsplwi mppdeyclmw vtadlvsftl ivgifvlqkw rlggirsynp eqimlsaavr
      541 rtsrdvsimk eklifseisd gvevsdvlsv csdnsydtya nstatpvgpr gggshtktli
      601 ersgr
//
LOCUS       XP_054226041             605 aa            linear   PRI 05-AUG-2025
DEFINITION  glycerophosphodiester phosphodiesterase domain-containing protein 5
            isoform X2 [Homo sapiens].
ACCESSION   XP_054226041
VERSION     XP_054226041.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370066.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..605
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..605
                     /product="glycerophosphodiester phosphodiesterase
                     domain-containing protein 5 isoform X2"
                     /calculated_mol_wt=68455
     Region          227..576
                     /region_name="GDPD_GDE2"
                     /note="Glycerophosphodiester phosphodiesterase domain of
                     mammalian glycerophosphodiester phosphodiesterase GDE2 and
                     similar proteins; cd08608"
                     /db_xref="CDD:176550"
     Site            order(233,260,262,275,358,394,454)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:176550"
     Site            order(233,275)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:176550"
     Site            order(260,262,358)
                     /site_type="other"
                     /note="putative metal binding site [ion binding]"
                     /db_xref="CDD:176550"
     CDS             1..605
                     /gene="GDPD5"
                     /gene_synonym="GDE2; PP1665"
                     /coded_by="XM_054370066.1:618..2435"
                     /db_xref="GeneID:81544"
                     /db_xref="HGNC:HGNC:28804"
                     /db_xref="MIM:609632"
ORIGIN      
        1 mvrhqplqyy epqlclsclt giygcrwkry qrshddttpw erlwfllltf tfgltltwly
       61 fwwevhndyd efnwylynrm gywsdwpvpi lvttaaafay iagllvlalc hiavgqqmnl
      121 hwlhkiglvv ilastvvams avaqlwedew evllislqgt apflhvgava avtmlswiva
      181 gqfaraerts sqvtilctff tvvfalylap ltisspcime kkdlgpkpal ighrgapmla
      241 pehtlmsfrk aleqklyglq aditisldgv pflmhdttlr rttnveeefp elarrpasml
      301 nwttlqrlna gqwflktdpf wtasslspsd hreaqnqsic slaellelak gnatlllnlr
      361 dpprehpyrs sfinvtleav lhsgfpqhqv mwlpsrqrpl vrkvapgfqq tsgskeavas
      421 lrrghiqrln lrytqvsrqe lrdyaswnls vnlytvnapw lfsllwcagv psvtsdnsha
      481 lsqvpsplwi mppdeyclmw vtadlvsftl ivgifvlqkw rlggirsynp eqimlsaavr
      541 rtsrdvsimk eklifseisd gvevsdvlsv csdnsydtya nstatpvgpr gggshtktli
      601 ersgr
//
LOCUS       XP_054226042             605 aa            linear   PRI 05-AUG-2025
DEFINITION  glycerophosphodiester phosphodiesterase domain-containing protein 5
            isoform X2 [Homo sapiens].
ACCESSION   XP_054226042
VERSION     XP_054226042.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370067.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..605
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..605
                     /product="glycerophosphodiester phosphodiesterase
                     domain-containing protein 5 isoform X2"
                     /calculated_mol_wt=68455
     Region          227..576
                     /region_name="GDPD_GDE2"
                     /note="Glycerophosphodiester phosphodiesterase domain of
                     mammalian glycerophosphodiester phosphodiesterase GDE2 and
                     similar proteins; cd08608"
                     /db_xref="CDD:176550"
     Site            order(233,260,262,275,358,394,454)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:176550"
     Site            order(233,275)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:176550"
     Site            order(260,262,358)
                     /site_type="other"
                     /note="putative metal binding site [ion binding]"
                     /db_xref="CDD:176550"
     CDS             1..605
                     /gene="GDPD5"
                     /gene_synonym="GDE2; PP1665"
                     /coded_by="XM_054370067.1:438..2255"
                     /db_xref="GeneID:81544"
                     /db_xref="HGNC:HGNC:28804"
                     /db_xref="MIM:609632"
ORIGIN      
        1 mvrhqplqyy epqlclsclt giygcrwkry qrshddttpw erlwfllltf tfgltltwly
       61 fwwevhndyd efnwylynrm gywsdwpvpi lvttaaafay iagllvlalc hiavgqqmnl
      121 hwlhkiglvv ilastvvams avaqlwedew evllislqgt apflhvgava avtmlswiva
      181 gqfaraerts sqvtilctff tvvfalylap ltisspcime kkdlgpkpal ighrgapmla
      241 pehtlmsfrk aleqklyglq aditisldgv pflmhdttlr rttnveeefp elarrpasml
      301 nwttlqrlna gqwflktdpf wtasslspsd hreaqnqsic slaellelak gnatlllnlr
      361 dpprehpyrs sfinvtleav lhsgfpqhqv mwlpsrqrpl vrkvapgfqq tsgskeavas
      421 lrrghiqrln lrytqvsrqe lrdyaswnls vnlytvnapw lfsllwcagv psvtsdnsha
      481 lsqvpsplwi mppdeyclmw vtadlvsftl ivgifvlqkw rlggirsynp eqimlsaavr
      541 rtsrdvsimk eklifseisd gvevsdvlsv csdnsydtya nstatpvgpr gggshtktli
      601 ersgr
//
LOCUS       XP_054226043             605 aa            linear   PRI 05-AUG-2025
DEFINITION  glycerophosphodiester phosphodiesterase domain-containing protein 5
            isoform X2 [Homo sapiens].
ACCESSION   XP_054226043
VERSION     XP_054226043.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370068.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 1% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..605
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..605
                     /product="glycerophosphodiester phosphodiesterase
                     domain-containing protein 5 isoform X2"
                     /calculated_mol_wt=68455
     Region          227..576
                     /region_name="GDPD_GDE2"
                     /note="Glycerophosphodiester phosphodiesterase domain of
                     mammalian glycerophosphodiester phosphodiesterase GDE2 and
                     similar proteins; cd08608"
                     /db_xref="CDD:176550"
     Site            order(233,260,262,275,358,394,454)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:176550"
     Site            order(233,275)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:176550"
     Site            order(260,262,358)
                     /site_type="other"
                     /note="putative metal binding site [ion binding]"
                     /db_xref="CDD:176550"
     CDS             1..605
                     /gene="GDPD5"
                     /gene_synonym="GDE2; PP1665"
                     /coded_by="XM_054370068.1:1358..3175"
                     /db_xref="GeneID:81544"
                     /db_xref="HGNC:HGNC:28804"
                     /db_xref="MIM:609632"
ORIGIN      
        1 mvrhqplqyy epqlclsclt giygcrwkry qrshddttpw erlwfllltf tfgltltwly
       61 fwwevhndyd efnwylynrm gywsdwpvpi lvttaaafay iagllvlalc hiavgqqmnl
      121 hwlhkiglvv ilastvvams avaqlwedew evllislqgt apflhvgava avtmlswiva
      181 gqfaraerts sqvtilctff tvvfalylap ltisspcime kkdlgpkpal ighrgapmla
      241 pehtlmsfrk aleqklyglq aditisldgv pflmhdttlr rttnveeefp elarrpasml
      301 nwttlqrlna gqwflktdpf wtasslspsd hreaqnqsic slaellelak gnatlllnlr
      361 dpprehpyrs sfinvtleav lhsgfpqhqv mwlpsrqrpl vrkvapgfqq tsgskeavas
      421 lrrghiqrln lrytqvsrqe lrdyaswnls vnlytvnapw lfsllwcagv psvtsdnsha
      481 lsqvpsplwi mppdeyclmw vtadlvsftl ivgifvlqkw rlggirsynp eqimlsaavr
      541 rtsrdvsimk eklifseisd gvevsdvlsv csdnsydtya nstatpvgpr gggshtktli
      601 ersgr
//
LOCUS       XP_054226044             605 aa            linear   PRI 05-AUG-2025
DEFINITION  glycerophosphodiester phosphodiesterase domain-containing protein 5
            isoform X2 [Homo sapiens].
ACCESSION   XP_054226044
VERSION     XP_054226044.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370069.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..605
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..605
                     /product="glycerophosphodiester phosphodiesterase
                     domain-containing protein 5 isoform X2"
                     /calculated_mol_wt=68455
     Region          227..576
                     /region_name="GDPD_GDE2"
                     /note="Glycerophosphodiester phosphodiesterase domain of
                     mammalian glycerophosphodiester phosphodiesterase GDE2 and
                     similar proteins; cd08608"
                     /db_xref="CDD:176550"
     Site            order(233,260,262,275,358,394,454)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:176550"
     Site            order(233,275)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:176550"
     Site            order(260,262,358)
                     /site_type="other"
                     /note="putative metal binding site [ion binding]"
                     /db_xref="CDD:176550"
     CDS             1..605
                     /gene="GDPD5"
                     /gene_synonym="GDE2; PP1665"
                     /coded_by="XM_054370069.1:187..2004"
                     /db_xref="GeneID:81544"
                     /db_xref="HGNC:HGNC:28804"
                     /db_xref="MIM:609632"
ORIGIN      
        1 mvrhqplqyy epqlclsclt giygcrwkry qrshddttpw erlwfllltf tfgltltwly
       61 fwwevhndyd efnwylynrm gywsdwpvpi lvttaaafay iagllvlalc hiavgqqmnl
      121 hwlhkiglvv ilastvvams avaqlwedew evllislqgt apflhvgava avtmlswiva
      181 gqfaraerts sqvtilctff tvvfalylap ltisspcime kkdlgpkpal ighrgapmla
      241 pehtlmsfrk aleqklyglq aditisldgv pflmhdttlr rttnveeefp elarrpasml
      301 nwttlqrlna gqwflktdpf wtasslspsd hreaqnqsic slaellelak gnatlllnlr
      361 dpprehpyrs sfinvtleav lhsgfpqhqv mwlpsrqrpl vrkvapgfqq tsgskeavas
      421 lrrghiqrln lrytqvsrqe lrdyaswnls vnlytvnapw lfsllwcagv psvtsdnsha
      481 lsqvpsplwi mppdeyclmw vtadlvsftl ivgifvlqkw rlggirsynp eqimlsaavr
      541 rtsrdvsimk eklifseisd gvevsdvlsv csdnsydtya nstatpvgpr gggshtktli
      601 ersgr
//
LOCUS       XP_054226045             605 aa            linear   PRI 05-AUG-2025
DEFINITION  glycerophosphodiester phosphodiesterase domain-containing protein 5
            isoform X2 [Homo sapiens].
ACCESSION   XP_054226045
VERSION     XP_054226045.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370070.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..605
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..605
                     /product="glycerophosphodiester phosphodiesterase
                     domain-containing protein 5 isoform X2"
                     /calculated_mol_wt=68455
     Region          227..576
                     /region_name="GDPD_GDE2"
                     /note="Glycerophosphodiester phosphodiesterase domain of
                     mammalian glycerophosphodiester phosphodiesterase GDE2 and
                     similar proteins; cd08608"
                     /db_xref="CDD:176550"
     Site            order(233,260,262,275,358,394,454)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:176550"
     Site            order(233,275)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:176550"
     Site            order(260,262,358)
                     /site_type="other"
                     /note="putative metal binding site [ion binding]"
                     /db_xref="CDD:176550"
     CDS             1..605
                     /gene="GDPD5"
                     /gene_synonym="GDE2; PP1665"
                     /coded_by="XM_054370070.1:943..2760"
                     /db_xref="GeneID:81544"
                     /db_xref="HGNC:HGNC:28804"
                     /db_xref="MIM:609632"
ORIGIN      
        1 mvrhqplqyy epqlclsclt giygcrwkry qrshddttpw erlwfllltf tfgltltwly
       61 fwwevhndyd efnwylynrm gywsdwpvpi lvttaaafay iagllvlalc hiavgqqmnl
      121 hwlhkiglvv ilastvvams avaqlwedew evllislqgt apflhvgava avtmlswiva
      181 gqfaraerts sqvtilctff tvvfalylap ltisspcime kkdlgpkpal ighrgapmla
      241 pehtlmsfrk aleqklyglq aditisldgv pflmhdttlr rttnveeefp elarrpasml
      301 nwttlqrlna gqwflktdpf wtasslspsd hreaqnqsic slaellelak gnatlllnlr
      361 dpprehpyrs sfinvtleav lhsgfpqhqv mwlpsrqrpl vrkvapgfqq tsgskeavas
      421 lrrghiqrln lrytqvsrqe lrdyaswnls vnlytvnapw lfsllwcagv psvtsdnsha
      481 lsqvpsplwi mppdeyclmw vtadlvsftl ivgifvlqkw rlggirsynp eqimlsaavr
      541 rtsrdvsimk eklifseisd gvevsdvlsv csdnsydtya nstatpvgpr gggshtktli
      601 ersgr
//
LOCUS       XP_054226046             605 aa            linear   PRI 05-AUG-2025
DEFINITION  glycerophosphodiester phosphodiesterase domain-containing protein 5
            isoform X2 [Homo sapiens].
ACCESSION   XP_054226046
VERSION     XP_054226046.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370071.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..605
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..605
                     /product="glycerophosphodiester phosphodiesterase
                     domain-containing protein 5 isoform X2"
                     /calculated_mol_wt=68455
     Region          227..576
                     /region_name="GDPD_GDE2"
                     /note="Glycerophosphodiester phosphodiesterase domain of
                     mammalian glycerophosphodiester phosphodiesterase GDE2 and
                     similar proteins; cd08608"
                     /db_xref="CDD:176550"
     Site            order(233,260,262,275,358,394,454)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:176550"
     Site            order(233,275)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:176550"
     Site            order(260,262,358)
                     /site_type="other"
                     /note="putative metal binding site [ion binding]"
                     /db_xref="CDD:176550"
     CDS             1..605
                     /gene="GDPD5"
                     /gene_synonym="GDE2; PP1665"
                     /coded_by="XM_054370071.1:1080..2897"
                     /db_xref="GeneID:81544"
                     /db_xref="HGNC:HGNC:28804"
                     /db_xref="MIM:609632"
ORIGIN      
        1 mvrhqplqyy epqlclsclt giygcrwkry qrshddttpw erlwfllltf tfgltltwly
       61 fwwevhndyd efnwylynrm gywsdwpvpi lvttaaafay iagllvlalc hiavgqqmnl
      121 hwlhkiglvv ilastvvams avaqlwedew evllislqgt apflhvgava avtmlswiva
      181 gqfaraerts sqvtilctff tvvfalylap ltisspcime kkdlgpkpal ighrgapmla
      241 pehtlmsfrk aleqklyglq aditisldgv pflmhdttlr rttnveeefp elarrpasml
      301 nwttlqrlna gqwflktdpf wtasslspsd hreaqnqsic slaellelak gnatlllnlr
      361 dpprehpyrs sfinvtleav lhsgfpqhqv mwlpsrqrpl vrkvapgfqq tsgskeavas
      421 lrrghiqrln lrytqvsrqe lrdyaswnls vnlytvnapw lfsllwcagv psvtsdnsha
      481 lsqvpsplwi mppdeyclmw vtadlvsftl ivgifvlqkw rlggirsynp eqimlsaavr
      541 rtsrdvsimk eklifseisd gvevsdvlsv csdnsydtya nstatpvgpr gggshtktli
      601 ersgr
//
LOCUS       XP_054226047             605 aa            linear   PRI 05-AUG-2025
DEFINITION  glycerophosphodiester phosphodiesterase domain-containing protein 5
            isoform X2 [Homo sapiens].
ACCESSION   XP_054226047
VERSION     XP_054226047.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370072.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..605
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..605
                     /product="glycerophosphodiester phosphodiesterase
                     domain-containing protein 5 isoform X2"
                     /calculated_mol_wt=68455
     Region          227..576
                     /region_name="GDPD_GDE2"
                     /note="Glycerophosphodiester phosphodiesterase domain of
                     mammalian glycerophosphodiester phosphodiesterase GDE2 and
                     similar proteins; cd08608"
                     /db_xref="CDD:176550"
     Site            order(233,260,262,275,358,394,454)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:176550"
     Site            order(233,275)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:176550"
     Site            order(260,262,358)
                     /site_type="other"
                     /note="putative metal binding site [ion binding]"
                     /db_xref="CDD:176550"
     CDS             1..605
                     /gene="GDPD5"
                     /gene_synonym="GDE2; PP1665"
                     /coded_by="XM_054370072.1:695..2512"
                     /db_xref="GeneID:81544"
                     /db_xref="HGNC:HGNC:28804"
                     /db_xref="MIM:609632"
ORIGIN      
        1 mvrhqplqyy epqlclsclt giygcrwkry qrshddttpw erlwfllltf tfgltltwly
       61 fwwevhndyd efnwylynrm gywsdwpvpi lvttaaafay iagllvlalc hiavgqqmnl
      121 hwlhkiglvv ilastvvams avaqlwedew evllislqgt apflhvgava avtmlswiva
      181 gqfaraerts sqvtilctff tvvfalylap ltisspcime kkdlgpkpal ighrgapmla
      241 pehtlmsfrk aleqklyglq aditisldgv pflmhdttlr rttnveeefp elarrpasml
      301 nwttlqrlna gqwflktdpf wtasslspsd hreaqnqsic slaellelak gnatlllnlr
      361 dpprehpyrs sfinvtleav lhsgfpqhqv mwlpsrqrpl vrkvapgfqq tsgskeavas
      421 lrrghiqrln lrytqvsrqe lrdyaswnls vnlytvnapw lfsllwcagv psvtsdnsha
      481 lsqvpsplwi mppdeyclmw vtadlvsftl ivgifvlqkw rlggirsynp eqimlsaavr
      541 rtsrdvsimk eklifseisd gvevsdvlsv csdnsydtya nstatpvgpr gggshtktli
      601 ersgr
//
LOCUS       XP_054226048             549 aa            linear   PRI 05-AUG-2025
DEFINITION  glycerophosphodiester phosphodiesterase domain-containing protein 5
            isoform X3 [Homo sapiens].
ACCESSION   XP_054226048
VERSION     XP_054226048.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370073.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..549
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..549
                     /product="glycerophosphodiester phosphodiesterase
                     domain-containing protein 5 isoform X3"
                     /calculated_mol_wt=60851
     Region          170..520
                     /region_name="GDPD_GDE2"
                     /note="Glycerophosphodiester phosphodiesterase domain of
                     mammalian glycerophosphodiester phosphodiesterase GDE2 and
                     similar proteins; cd08608"
                     /db_xref="CDD:176550"
     Site            order(176,203,205,218,301,337,397)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:176550"
     Site            order(176,218)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:176550"
     Site            order(203,205,301)
                     /site_type="other"
                     /note="putative metal binding site [ion binding]"
                     /db_xref="CDD:176550"
     CDS             1..549
                     /gene="GDPD5"
                     /gene_synonym="GDE2; PP1665"
                     /coded_by="XM_054370073.1:101..1750"
                     /db_xref="GeneID:81544"
                     /db_xref="HGNC:HGNC:28804"
                     /db_xref="MIM:609632"
ORIGIN      
        1 mshcrgaade palaaqgcpe htallfcprl tplpqwqqpp aqdlhrggvc qrpnlspree
       61 hwvphspkig lvvilastvv amsavaqlwe dewevllisl qgtapflhvg avaavtmlsw
      121 ivagqfarae rtssqvtilc tfftvvfaly lapltisspc imekkdlgpk palighrgap
      181 mlapehtlms frkaleqkly glqaditisl dgvpflmhdt tlrrttnvee efpelarrpa
      241 smlnwttlqr lnagqwflkt dpfwtassls psdhreaqnq sicslaelle lakgnatlll
      301 nlrdpprehp yrssfinvtl eavlhsgfpq hqvmwlpsrq rplvrkvapg fqqtsgskea
      361 vaslrrghiq rlnlrytqvs rqelrdyasw nlsvnlytvn apwlfsllwc agvpsvtsdn
      421 shalsqvpsp lwimppdeyc lmwvtadlvs ftlivgifvl qkwrlggirs ynpeqimlsa
      481 avrrtsrdvs imkeklifsa eisdgvevsd vlsvcsdnsy dtyanstatp vgprgggsht
      541 ktliersgr
//
LOCUS       XP_054226049             468 aa            linear   PRI 05-AUG-2025
DEFINITION  glycerophosphodiester phosphodiesterase domain-containing protein 5
            isoform X4 [Homo sapiens].
ACCESSION   XP_054226049
VERSION     XP_054226049.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370074.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..468
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..468
                     /product="glycerophosphodiester phosphodiesterase
                     domain-containing protein 5 isoform X4"
                     /calculated_mol_wt=52079
     Region          89..439
                     /region_name="GDPD_GDE2"
                     /note="Glycerophosphodiester phosphodiesterase domain of
                     mammalian glycerophosphodiester phosphodiesterase GDE2 and
                     similar proteins; cd08608"
                     /db_xref="CDD:176550"
     Site            order(95,122,124,137,220,256,316)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:176550"
     Site            order(95,137)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:176550"
     Site            order(122,124,220)
                     /site_type="other"
                     /note="putative metal binding site [ion binding]"
                     /db_xref="CDD:176550"
     CDS             1..468
                     /gene="GDPD5"
                     /gene_synonym="GDE2; PP1665"
                     /coded_by="XM_054370074.1:412..1818"
                     /db_xref="GeneID:81544"
                     /db_xref="HGNC:HGNC:28804"
                     /db_xref="MIM:609632"
ORIGIN      
        1 msavaqlwed ewevllislq gtapflhvga vaavtmlswi vagqfaraer tssqvtilct
       61 fftvvfalyl apltisspci mekkdlgpkp alighrgapm lapehtlmsf rkaleqklyg
      121 lqaditisld gvpflmhdtt lrrttnveee fpelarrpas mlnwttlqrl nagqwflktd
      181 pfwtasslsp sdhreaqnqs icslaellel akgnatllln lrdpprehpy rssfinvtle
      241 avlhsgfpqh qvmwlpsrqr plvrkvapgf qqtsgskeav aslrrghiqr lnlrytqvsr
      301 qelrdyaswn lsvnlytvna pwlfsllwca gvpsvtsdns halsqvpspl wimppdeycl
      361 mwvtadlvsf tlivgifvlq kwrlggirsy npeqimlsaa vrrtsrdvsi mkeklifsae
      421 isdgvevsdv lsvcsdnsyd tyanstatpv gprgggshtk tliersgr
//
LOCUS       XP_054226050             361 aa            linear   PRI 05-AUG-2025
DEFINITION  glycerophosphodiester phosphodiesterase domain-containing protein 5
            isoform X5 [Homo sapiens].
ACCESSION   XP_054226050
VERSION     XP_054226050.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370075.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..361
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..361
                     /product="glycerophosphodiester phosphodiesterase
                     domain-containing protein 5 isoform X5"
                     /calculated_mol_wt=40517
     Region          1..332
                     /region_name="PI-PLCc_GDPD_SF"
                     /note="Catalytic domain of phosphoinositide-specific
                     phospholipase C-like phosphodiesterases superfamily;
                     cl14615"
                     /db_xref="CDD:472694"
     Site            order(15,17,113,151,209)
                     /site_type="active"
                     /db_xref="CDD:176550"
     CDS             1..361
                     /gene="GDPD5"
                     /gene_synonym="GDE2; PP1665"
                     /coded_by="XM_054370075.1:114..1199"
                     /db_xref="GeneID:81544"
                     /db_xref="HGNC:HGNC:28804"
                     /db_xref="MIM:609632"
ORIGIN      
        1 msfrkaleqk lyglqaditi sldgvpflmh dttlrrttnv eeefpelarr pasmlnwttl
       61 qrlnagqwfl ktdpfwtass lspsdhreaq nqsicslael lelakgnatl llnlrdppre
      121 hpyrssfinv tleavlhsgf pqhqvmwlps rqrplvrkva pgfqqtsgsk eavaslrrgh
      181 iqrlnlrytq vsrqelrdya swnlsvnlyt vnapwlfsll wcagvpsvts dnshalsqvp
      241 splwimppde yclmwvtadl vsftlivgif vlqkwrlggi rsynpeqiml saavrrtsrd
      301 vsimkeklif saeisdgvev sdvlsvcsdn sydtyansta tpvgprgggs htktliersg
      361 r
//
LOCUS       XP_054226051             678 aa            linear   PRI 05-AUG-2025
DEFINITION  mitochondrial disaggregase isoform X1 [Homo sapiens].
ACCESSION   XP_054226051
VERSION     XP_054226051.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370076.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..678
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..678
                     /product="mitochondrial disaggregase isoform X1"
                     /calculated_mol_wt=75424
     Region          <132..292
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          237..267
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          <310..626
                     /region_name="ClpA"
                     /note="ATP-dependent Clp protease, ATP-binding subunit
                     ClpA [Posttranslational modification, protein turnover,
                     chaperones]; COG0542"
                     /db_xref="CDD:440308"
     CDS             1..678
                     /gene="CLPB"
                     /gene_synonym="ANKCLB; ANKCLP; HSP78; MEGCANN; MGCA7;
                     MGCA7A; SCN9; SKD3"
                     /coded_by="XM_054370076.1:58..2094"
                     /db_xref="GeneID:81570"
                     /db_xref="HGNC:HGNC:30664"
                     /db_xref="MIM:616254"
ORIGIN      
        1 mlgslvlrrk alaprlllrl lrsptlrghg gasgrnvttg slgepqwlrv atggrpgtsp
       61 alfsgrgaat ggrqggrfdt kclaaatwgr lpgpeetlpg qdswngvpsr aglgmcalaa
      121 alvvhcysks psnkdaalle aarannmqev ssvvqvllaa gadpnlgddf ssvyktakeq
      181 gihsledggq dgasrhitnq wtsalefrrw lglpagvlit reddfnnrln nrasfkgcta
      241 lhyavladdy rtvkelldgg anplqrnemg htpldyareg evmkllrtse akyqekqrkr
      301 eaeerrrfpl eqrlkehiig qesaiatvga airrkengwy deehplvflf lgssgigkte
      361 lakqtakymh kdakkgfirl dmsefqerhe vakfigsppg yvgheeggql tkklkqcpna
      421 vvlfdevdka hpdvltimlq lfdegrltdg kgktidckda ifimtsnvas deiaqhalql
      481 rqealemsrn riaenlgdvq isdkitiskn fkenvirpil kahfrrdefl grineivyfl
      541 pfchseliql vnkelnfwak rakqrhnitl lwdrevadvl vdgynvhyga rsikheverr
      601 vvnqlaaaye qdllpggctl ritvedsdkq llkspelpsp qaekrlpklr leiidkdskt
      661 rrldiraplh pekvcnti
//
LOCUS       XP_054226052             632 aa            linear   PRI 05-AUG-2025
DEFINITION  mitochondrial disaggregase isoform X2 [Homo sapiens].
ACCESSION   XP_054226052
VERSION     XP_054226052.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370077.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..632
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..632
                     /product="mitochondrial disaggregase isoform X2"
                     /calculated_mol_wt=71132
     Region          <107..246
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          121..152
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          190..215
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          <264..580
                     /region_name="ClpA"
                     /note="ATP-dependent Clp protease, ATP-binding subunit
                     ClpA [Posttranslational modification, protein turnover,
                     chaperones]; COG0542"
                     /db_xref="CDD:440308"
     CDS             1..632
                     /gene="CLPB"
                     /gene_synonym="ANKCLB; ANKCLP; HSP78; MEGCANN; MGCA7;
                     MGCA7A; SCN9; SKD3"
                     /coded_by="XM_054370077.1:300..2198"
                     /db_xref="GeneID:81570"
                     /db_xref="HGNC:HGNC:30664"
                     /db_xref="MIM:616254"
ORIGIN      
        1 mprgchlgtp swsrrntprt gqlergpqqg rtghvrpgrs aggsllqqes vqqgcspvgs
       61 cpcqqyarsq qpqetaknda qsrswaglna gvslkntkis ssewplrlls egadvnakhr
      121 lgwtalmvaa inrnnsvvqv llaagadpnl gddfssvykt akeqgihsle vlitreddfn
      181 nrlnnrasfk gctalhyavl addyrtvkel ldgganplqr nemghtpldy aregevmkll
      241 rtseakyqek qrkreaeerr rfpleqrlke hiigqesaia tvgaairrke ngwydeehpl
      301 vflflgssgi gktelakqta kymhkdakkg firldmsefq erhevakfig sppgyvghee
      361 ggqltkklkq cpnavvlfde vdkahpdvlt imlqlfdegr ltdgkgktid ckdaifimts
      421 nvasdeiaqh alqlrqeale msrnriaenl gdvqisdkit isknfkenvi rpilkahfrr
      481 deflgrinei vyflpfchse liqlvnkeln fwakrakqrh nitllwdrev advlvdgynv
      541 hygarsikhe verrvvnqla aayeqdllpg gctlritved sdkqllkspe lpspqaekrl
      601 pklrleiidk dsktrrldir aplhpekvcn ti
//
LOCUS       XP_054226053             536 aa            linear   PRI 05-AUG-2025
DEFINITION  mitochondrial disaggregase isoform X3 [Homo sapiens].
ACCESSION   XP_054226053
VERSION     XP_054226053.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370078.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 27% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..536
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..536
                     /product="mitochondrial disaggregase isoform X3"
                     /calculated_mol_wt=60813
     Region          <1..150
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Site            order(1..2,5..7,9..10,14,17,26,28,96,100..101,104..106,
                     108..109,113,116,125,127,129,133..134,136..138,139,143)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          28..125
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          <168..484
                     /region_name="ClpA"
                     /note="ATP-dependent Clp protease, ATP-binding subunit
                     ClpA [Posttranslational modification, protein turnover,
                     chaperones]; COG0542"
                     /db_xref="CDD:440308"
     CDS             1..536
                     /gene="CLPB"
                     /gene_synonym="ANKCLB; ANKCLP; HSP78; MEGCANN; MGCA7;
                     MGCA7A; SCN9; SKD3"
                     /coded_by="XM_054370078.1:780..2390"
                     /db_xref="GeneID:81570"
                     /db_xref="HGNC:HGNC:30664"
                     /db_xref="MIM:616254"
ORIGIN      
        1 mvaainrnns vvqvllaaga dpnlgddfss vyktakeqgi hsledggqdg asrhitnqwt
       61 salefrrwlg lpagvlitre ddfnnrlnnr asfkgctalh yavladdyrt vkelldggan
      121 plqrnemght pldyaregev mkllrtseak yqekqrkrea eerrrfpleq rlkehiigqe
      181 saiatvgaai rrkengwyde ehplvflflg ssgigktela kqtakymhkd akkgfirldm
      241 sefqerheva kfigsppgyv gheeggqltk klkqcpnavv lfdevdkahp dvltimlqlf
      301 degrltdgkg ktidckdaif imtsnvasde iaqhalqlrq ealemsrnri aenlgdvqis
      361 dkitisknfk envirpilka hfrrdeflgr ineivyflpf chseliqlvn kelnfwakra
      421 kqrhnitllw drevadvlvd gynvhygars ikheverrvv nqlaaayeqd llpggctlri
      481 tvedsdkqll kspelpspqa ekrlpklrle iidkdsktrr ldiraplhpe kvcnti
//
LOCUS       XP_054226054             371 aa            linear   PRI 05-AUG-2025
DEFINITION  mitochondrial disaggregase isoform X4 [Homo sapiens].
ACCESSION   XP_054226054
VERSION     XP_054226054.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370079.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 1% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..371
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..371
                     /product="mitochondrial disaggregase isoform X4"
                     /calculated_mol_wt=39956
     Region          <132..321
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Region          137..164
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          166..197
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          266..296
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     CDS             1..371
                     /gene="CLPB"
                     /gene_synonym="ANKCLB; ANKCLP; HSP78; MEGCANN; MGCA7;
                     MGCA7A; SCN9; SKD3"
                     /coded_by="XM_054370079.1:58..1173"
                     /db_xref="GeneID:81570"
                     /db_xref="HGNC:HGNC:30664"
                     /db_xref="MIM:616254"
ORIGIN      
        1 mlgslvlrrk alaprlllrl lrsptlrghg gasgrnvttg slgepqwlrv atggrpgtsp
       61 alfsgrgaat ggrqggrfdt kclaaatwgr lpgpeetlpg qdswngvpsr aglgmcalaa
      121 alvvhcysks psnkdaalle aarannmqev srllsegadv nakhrlgwta lmvaainrnn
      181 svvqvllaag adpnlgddfs svyktakeqg ihsledggqd gasrhitnqw tsalefrrwl
      241 glpagvlitr eddfnnrlnn rasfkgctal hyavladdyr tvkelldgga nplqrnemgh
      301 tpldyarege vmkllrtsea kyqekqrkre aeerrrfple qrlkehiigq esaiatvgag
      361 dphqahpglm p
//
LOCUS       XP_054226055             460 aa            linear   PRI 05-AUG-2025
DEFINITION  protein unc-93 homolog B1 isoform X1 [Homo sapiens].
ACCESSION   XP_054226055
VERSION     XP_054226055.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370080.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..460
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..460
                     /product="protein unc-93 homolog B1 isoform X1"
                     /calculated_mol_wt=51231
     Region          1..383
                     /region_name="MFS"
                     /note="Major Facilitator Superfamily; cl28910"
                     /db_xref="CDD:475125"
     Site            order(35..36,38..40,43,92,95..96,99,210,213..214,217..219,
                     222,249,253,300..301,305,309,334,337..338,341..342,345)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:349949"
     CDS             1..460
                     /gene="UNC93B1"
                     /gene_synonym="IIAE1; UNC-93B; Unc-93B1; UNC93; UNC93B"
                     /coded_by="XM_054370080.1:104..1486"
                     /db_xref="GeneID:81622"
                     /db_xref="HGNC:HGNC:13481"
                     /db_xref="MIM:608204"
ORIGIN      
        1 mmflavgiya lfvstnywer yytlvpsava lgmaivplwa smgnyitrma qkyheyshyk
       61 eqdgqgmkqr pprgshapyl lvfqaifysf fhlsfacaql pmiyflnhyl ydlnhtlynv
      121 qscgtnshgi lsgfnktvlr tlprsgnliv vesvlmavaf lamllvlglc gaayrpteei
      181 dlrsvgwgni fqlpfkhvrd yrlrhlvpff iysgfevlfa ctgialgygv csvglerlay
      241 llvayslgas aasllgllgl wlprpvplva gagvhllltf ilffwapvpr vlqhswilyv
      301 aaalwgvgsa lnktglstll gilyedkerq dfiftiyhww qavaiftvyl gsslhmkakl
      361 avllvtlvaa avsylrmeqk lrrgvaprqp riprpqhkvr gyryleedns desdaegehg
      421 dgaeeeappa gprpgpepag lgrrpcpyeq aqggdgpeeq
//
LOCUS       XP_054226056             412 aa            linear   PRI 05-AUG-2025
DEFINITION  protein unc-93 homolog B1 isoform X2 [Homo sapiens].
ACCESSION   XP_054226056
VERSION     XP_054226056.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370081.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..412
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..412
                     /product="protein unc-93 homolog B1 isoform X2"
                     /calculated_mol_wt=45796
     Region          <1..335
                     /region_name="MFS"
                     /note="Major Facilitator Superfamily; cl28910"
                     /db_xref="CDD:475125"
     CDS             1..412
                     /gene="UNC93B1"
                     /gene_synonym="IIAE1; UNC-93B; Unc-93B1; UNC93; UNC93B"
                     /coded_by="XM_054370081.1:146..1384"
                     /db_xref="GeneID:81622"
                     /db_xref="HGNC:HGNC:13481"
                     /db_xref="MIM:608204"
ORIGIN      
        1 maqkyheysh ykeqdgqgmk qrpprgshap yllvfqaify sffhlsfaca qlpmiyflnh
       61 ylydlnhtly nvqscgtnsh gilsgfnktv lrtlprsgnl ivvesvlmav aflamllvlg
      121 lcgaayrpte eidlrsvgwg nifqlpfkhv rdyrlrhlvp ffiysgfevl factgialgy
      181 gvcsvglerl ayllvayslg asaasllgll glwlprpvpl vagagvhlll tfilffwapv
      241 prvlqhswil yvaaalwgvg salnktglst llgilyedke rqdfiftiyh wwqavaiftv
      301 ylgsslhmka klavllvtlv aaavsylrme qklrrgvapr qpriprpqhk vrgyryleed
      361 nsdesdaege hgdgaeeeap pagprpgpep aglgrrpcpy eqaqggdgpe eq
//
LOCUS       XP_054226057            1843 aa            linear   PRI 05-AUG-2025
DEFINITION  myotubularin-related protein 13 isoform X6 [Homo sapiens].
ACCESSION   XP_054226057
VERSION     XP_054226057.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370082.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1843
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1843
                     /product="myotubularin-related protein 13 isoform X6"
                     /calculated_mol_wt=207752
     Region          1..86
                     /region_name="uDENN"
                     /note="Domain always found upstream of DENN domain, found
                     in a variety of signalling proteins; smart00800"
                     /db_xref="CDD:214824"
     Region          116..295
                     /region_name="DENN"
                     /note="DENN (AEX-3) domain; pfam02141"
                     /db_xref="CDD:460461"
     Region          314..382
                     /region_name="dDENN"
                     /note="Domain always found downstream of DENN domain,
                     found in a variety of signalling proteins; smart00801"
                     /db_xref="CDD:129037"
     Region          492..716
                     /region_name="SBF2"
                     /note="Myotubularin protein; pfam12335"
                     /db_xref="CDD:463536"
     Region          844..962
                     /region_name="PH-GRAM_MTMR13"
                     /note="Myotubularian (MTM) related 13 protein Pleckstrin
                     Homology-Glucosyltransferases, Rab-like GTPase activators
                     and Myotubularins (PH-GRAM) domain; cd13339"
                     /db_xref="CDD:275416"
     Region          1100..1479
                     /region_name="PTP-MTMR13"
                     /note="protein tyrosine phosphatase-like pseudophosphatase
                     domain of myotubularin related phosphoinositide
                     phosphatase 13; cd14589"
                     /db_xref="CDD:350437"
     Region          1736..1841
                     /region_name="PH_Sbf1_hMTMR5"
                     /note="Set binding factor 1 (also called Human MTMR5)
                     Pleckstrin Homology (PH) domain; cd01235"
                     /db_xref="CDD:269941"
     CDS             1..1843
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /coded_by="XM_054370082.1:17..5548"
                     /db_xref="GeneID:81846"
                     /db_xref="HGNC:HGNC:2135"
                     /db_xref="MIM:607697"
ORIGIN      
        1 marladyfiv vgydhekpgs geglgkiiqr fpqkdwddtp fpqgielfcq pggwqlsrer
       61 kqptffvvvl tdidsdrhyc scltfyeaei nlqgtkkeei egeakvsgli qpaevfapks
      121 lvlvsrlyyp eifraclgli ytvyvdslnv sleslianlc aclvpaaggs qklfslgagd
      181 rqliqtplhd slpitgtsva llfqqlgiqn vlslfcavlt enkvlfhsas fqrlsdacra
      241 leslmfplky sypyipilpa qllevlsspt pfiigvhsvf ktdvhelilh pdlevadhaf
      301 ppprtalshs kmldkevrav flrlfaqlfq gyrsclqlir ihaepvihfh ktaflgqrgl
      361 vendfltkvl sgmafagfvs ergppyrscd lfdelvafev erikveennp vkmikhvrel
      421 aeqlfknenp nphmafqkvp rptegshlrv hilpfpeine arvqeliqen vaknqnappa
      481 triekkcvvp agppvvsimd kvttvfnsaq rlevvrncis fifenkilet ektlpaalra
      541 lkgkaarqcl tdelglhvqq nraildhqqf dyiirmmnct lqdcssleey niaaallplt
      601 safyrklapg vsqfaytcvq dhpiwtnqqf wettfynavq eqvrslylsa kednhaphlk
      661 qkdklpddhy qektamdlaa eqlrlwptls kstqqelvqh eestvfsqai hfanlmvnll
      721 vpldtsknkl lrtsapgdwe sgsnsivtns iagsvaesyd tesgfedsen tdiansvvrf
      781 itrfidkvct esgvtqdhik slhcmipgiv amhietleav hresrrlppi qkpkilrpal
      841 lpgeeivceg lrvlldpdgr eeatggllgg pqllpaegal flttyrilfr gtphdqlvge
      901 qtvvrsfpia sitkekkitm qnqlqqnmqe glqitsasfq likvafdeev spevveifkk
      961 qlmkfrypqs ifstfafaag qttpqiilpk qkekntsfrt fsktivkgak ragkmtigrq
     1021 yllkkktgti veervnrpgw nedddvsvsd eselptsttl kasekstmeq lvekacfrdy
     1081 qrlglgtisg sssrsrpeyf ritasnrmys lcrsypgllv vpqavqdssl prvarcyrhn
     1141 rlpvvcwkns rsgtlllrsg gfhgkgvvgl fksqnspqaa ptsslessss ieqekylqal
     1201 lnavsvhqkl rgnstltvrp afalspgter rtsrmstvlk qvvpghldvn psnsfaqggv
     1261 waslrsstrl issptsfidv garlagkdhs asfsnssylq nqllkrqaal yifgeksqlr
     1321 nfkvefalnc efvpvefhei rqvkasfkkl mracipstip tdsevtflka lgdsewfpql
     1381 hrimqlavvv sevlengssv lvcleegwdi taqvtslvql lsdpfyrtle gfqmlvekew
     1441 lsfghkfsqr ssltlncqgs gfapvflqfl dcvhqvhnqy ptefefnlyy lkflafhyvs
     1501 nrfktfllds dyerlehgtl fddkgekhak kgvciwecid rmhkrspiff nylyspleie
     1561 alkpnvnvss lkkwdyyiee tlstgpsydw mmltpkhfps edsdlageag prsqrrtvwp
     1621 cyddvsctqp daltslfsei eklehklnqa pekwqqlwer vtvdlkeepr tdrsqrhlsr
     1681 spgivstnlp syqkrsllhl pdssmgeeqn ssispsngve rraatlysqy tskndenrsf
     1741 egtlykrgal lkgwkprwfv ldvtkhqlry ydsgedtsck ghidlaevem vipagpsmga
     1801 pkhtsdkaff dlktskrvyn fcaqdgqsaq qwmdkiqsci sda
//
LOCUS       XP_054226058            1838 aa            linear   PRI 05-AUG-2025
DEFINITION  myotubularin-related protein 13 isoform X7 [Homo sapiens].
ACCESSION   XP_054226058
VERSION     XP_054226058.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370083.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1838
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1838
                     /product="myotubularin-related protein 13 isoform X7"
                     /calculated_mol_wt=207062
     Region          1..86
                     /region_name="uDENN"
                     /note="Domain always found upstream of DENN domain, found
                     in a variety of signalling proteins; smart00800"
                     /db_xref="CDD:214824"
     Region          116..298
                     /region_name="DENN"
                     /note="DENN (AEX-3) domain; pfam02141"
                     /db_xref="CDD:460461"
     Region          352..421
                     /region_name="dDENN"
                     /note="Domain always found downstream of DENN domain,
                     found in a variety of signalling proteins; smart00801"
                     /db_xref="CDD:129037"
     Region          487..711
                     /region_name="SBF2"
                     /note="Myotubularin protein; pfam12335"
                     /db_xref="CDD:463536"
     Region          839..957
                     /region_name="PH-GRAM_MTMR13"
                     /note="Myotubularian (MTM) related 13 protein Pleckstrin
                     Homology-Glucosyltransferases, Rab-like GTPase activators
                     and Myotubularins (PH-GRAM) domain; cd13339"
                     /db_xref="CDD:275416"
     Region          1095..1474
                     /region_name="PTP-MTMR13"
                     /note="protein tyrosine phosphatase-like pseudophosphatase
                     domain of myotubularin related phosphoinositide
                     phosphatase 13; cd14589"
                     /db_xref="CDD:350437"
     Region          1731..1836
                     /region_name="PH_Sbf1_hMTMR5"
                     /note="Set binding factor 1 (also called Human MTMR5)
                     Pleckstrin Homology (PH) domain; cd01235"
                     /db_xref="CDD:269941"
     CDS             1..1838
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /coded_by="XM_054370083.1:17..5533"
                     /db_xref="GeneID:81846"
                     /db_xref="HGNC:HGNC:2135"
                     /db_xref="MIM:607697"
ORIGIN      
        1 marladyfiv vgydhekpgs geglgkiiqr fpqkdwddtp fpqgielfcq pggwqlsrer
       61 kqptffvvvl tdidsdrhyc scltfyeaei nlqgtkkeei egeakvsgli qpaevfapks
      121 lvlvsrlyyp eifraclgli ytvyvdslnv sleslianlc aclvpaaggs qklfslgagd
      181 rqliqtplhd slpitgtsva llfqqlgiqn vlslfcavlt enkvlfhsas fqrlsdacra
      241 leslmfplky sypyipilpa qllevlsspt pfiigvhsvf ktdvhelldv iiadldggti
      301 kipecihlss lpepllhqtq salslilhpd levadhafpp prtalshskm ldkevravfl
      361 rlfaqlfqgy rsclqlirih aepvihfhkl vafeverikv eennpvkmik hvrelaeqlf
      421 knenpnphma fqkvprpteg shlrvhilpf peinearvqe liqenvaknq nappatriek
      481 kcvvpagppv vsimdkvttv fnsaqrlevv rncisfifen kiletektlp aalralkgka
      541 arqcltdelg lhvqqnrail dhqqfdyiir mmnctlqdcs sleeyniaaa llpltsafyr
      601 klapgvsqfa ytcvqdhpiw tnqqfwettf ynavqeqvrs lylsakednh aphlkqkdkl
      661 pddhyqekta mdlaaeqlrl wptlskstqq elvqheestv fsqaihfanl mvnllvpldt
      721 sknkllrtsa pgdwesgsns ivtnsiagsv aesydtesgf edsentdian svvrfitrfi
      781 dkvctesgvt qdhikslhcm ipgivamhie tleavhresr rlppiqkpki lrpallpgee
      841 ivceglrvll dpdgreeatg gllggpqllp aegalfltty rilfrgtphd qlvgeqtvvr
      901 sfpiasitke kkitmqnqlq qnmqeglqit sasfqlikva fdeevspevv eifkkqlmkf
      961 rypqsifstf afaagqttpq iilpkqkekn tsfrtfskti vkgakragkm tigrqyllkk
     1021 ktgtiveerv nrpgwneddd vsvsdeselp tsttlkasek stmeqlveka cfrdyqrlgl
     1081 gtisgsssrs rpeyfritas nrmyslcrsy pgllvvpqav qdsslprvar cyrhnrlpvv
     1141 cwknsrsgtl llrsggfhgk gvvglfksqn spqaaptssl essssieqek ylqallnavs
     1201 vhqklrgnst ltvrpafals pgterrtsrm stvlkqvvpg hldvnpsnsf aqggvwaslr
     1261 sstrlisspt sfidvgarla gkdhsasfsn ssylqnqllk rqaalyifge ksqlrnfkve
     1321 falncefvpv efheirqvka sfkklmraci pstiptdsev tflkalgdse wfpqlhrimq
     1381 lavvvsevle ngssvlvcle egwditaqvt slvqllsdpf yrtlegfqml vekewlsfgh
     1441 kfsqrssltl ncqgsgfapv flqfldcvhq vhnqyptefe fnlyylkfla fhyvsnrfkt
     1501 flldsdyerl ehgtlfddkg ekhakkgvci wecidrmhkr spiffnylys pleiealkpn
     1561 vnvsslkkwd yyieetlstg psydwmmltp khfpsedsdl ageagprsqr rtvwpcyddv
     1621 sctqpdalts lfseiekleh klnqapekwq qlwervtvdl keeprtdrsq rhlsrspgiv
     1681 stnlpsyqkr sllhlpdssm geeqnssisp sngverraat lysqytsknd enrsfegtly
     1741 krgallkgwk prwfvldvtk hqlryydsge dtsckghidl aevemvipag psmgapkhts
     1801 dkaffdlkts krvynfcaqd gqsaqqwmdk iqscisda
//
LOCUS       XP_054226059            1835 aa            linear   PRI 05-AUG-2025
DEFINITION  myotubularin-related protein 13 isoform X8 [Homo sapiens].
ACCESSION   XP_054226059
VERSION     XP_054226059.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370084.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1835
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1835
                     /product="myotubularin-related protein 13 isoform X8"
                     /calculated_mol_wt=206599
     Region          <1..38
                     /region_name="uDENN"
                     /note="uDENN domain; pfam03456"
                     /db_xref="CDD:460926"
     Region          70..252
                     /region_name="DENN"
                     /note="DENN (AEX-3) domain; pfam02141"
                     /db_xref="CDD:460461"
     Region          306..374
                     /region_name="dDENN"
                     /note="Domain always found downstream of DENN domain,
                     found in a variety of signalling proteins; smart00801"
                     /db_xref="CDD:129037"
     Region          484..708
                     /region_name="SBF2"
                     /note="Myotubularin protein; pfam12335"
                     /db_xref="CDD:463536"
     Region          836..954
                     /region_name="PH-GRAM_MTMR13"
                     /note="Myotubularian (MTM) related 13 protein Pleckstrin
                     Homology-Glucosyltransferases, Rab-like GTPase activators
                     and Myotubularins (PH-GRAM) domain; cd13339"
                     /db_xref="CDD:275416"
     Region          1092..1471
                     /region_name="PTP-MTMR13"
                     /note="protein tyrosine phosphatase-like pseudophosphatase
                     domain of myotubularin related phosphoinositide
                     phosphatase 13; cd14589"
                     /db_xref="CDD:350437"
     Region          1728..1833
                     /region_name="PH_Sbf1_hMTMR5"
                     /note="Set binding factor 1 (also called Human MTMR5)
                     Pleckstrin Homology (PH) domain; cd01235"
                     /db_xref="CDD:269941"
     CDS             1..1835
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /coded_by="XM_054370084.1:5002..10509"
                     /db_xref="GeneID:81846"
                     /db_xref="HGNC:HGNC:2135"
                     /db_xref="MIM:607697"
ORIGIN      
        1 mfcqpggwql srerkqptff vvvltdidsd rhycscltfy eaeinlqgtk keeiegeakv
       61 sgliqpaevf apkslvlvsr lyypeifrac lgliytvyvd slnvslesli anlcaclvpa
      121 aggsqklfsl gagdrqliqt plhdslpitg tsvallfqql giqnvlslfc avltenkvlf
      181 hsasfqrlsd acraleslmf plkysypyip ilpaqllevl ssptpfiigv hsvfktdvhe
      241 lldviiadld ggtikipeci hlsslpepll hqtqsalsli lhpdlevadh afppprtals
      301 hskmldkevr avflrlfaql fqgyrsclql irihaepvih fhktaflgqr glvendfltk
      361 vlsgmafagf vsergppyrs cdlfdelvaf everikveen npvkmikhvr elaeqlfkne
      421 npnphmafqk vprptegshl rvhilpfpei nearvqeliq envaknqnap patriekkcv
      481 vpagppvvsi mdkvttvfns aqrlevvrnc isfifenkil etektlpaal ralkgkaarq
      541 cltdelglhv qqnraildhq qfdyiirmmn ctlqdcssle eyniaaallp ltsafyrkla
      601 pgvsqfaytc vqdhpiwtnq qfwettfyna vqeqvrslyl sakednhaph lkqkdklpdd
      661 hyqektamdl aaeqlrlwpt lskstqqelv qheestvfsq aihfanlmvn llvpldtskn
      721 kllrtsapgd wesgsnsivt nsiagsvaes ydtesgfeds entdiansvv rfitrfidkv
      781 ctesgvtqdh ikslhcmipg ivamhietle avhresrrlp piqkpkilrp allpgeeivc
      841 eglrvlldpd greeatggll ggpqllpaeg alflttyril frgtphdqlv geqtvvrsfp
      901 iasitkekki tmqnqlqqnm qeglqitsas fqlikvafde evspevveif kkqlmkfryp
      961 qsifstfafa agqttpqiil pkqkekntsf rtfsktivkg akragkmtig rqyllkkktg
     1021 tiveervnrp gwnedddvsv sdeselptst tlkasekstm eqlvekacfr dyqrlglgti
     1081 sgsssrsrpe yfritasnrm yslcrsypgl lvvpqavqds slprvarcyr hnrlpvvcwk
     1141 nsrsgtlllr sggfhgkgvv glfksqnspq aaptssless ssieqekylq allnavsvhq
     1201 klrgnstltv rpafalspgt errtsrmstv lkqvvpghld vnpsnsfaqg gvwaslrsst
     1261 rlissptsfi dvgarlagkd hsasfsnssy lqnqllkrqa alyifgeksq lrnfkvefal
     1321 ncefvpvefh eirqvkasfk klmracipst iptdsevtfl kalgdsewfp qlhrimqlav
     1381 vvsevlengs svlvcleegw ditaqvtslv qllsdpfyrt legfqmlvek ewlsfghkfs
     1441 qrssltlncq gsgfapvflq fldcvhqvhn qyptefefnl yylkflafhy vsnrfktfll
     1501 dsdyerlehg tlfddkgekh akkgvciwec idrmhkrspi ffnylysple iealkpnvnv
     1561 sslkkwdyyi eetlstgpsy dwmmltpkhf psedsdlage agprsqrrtv wpcyddvsct
     1621 qpdaltslfs eieklehkln qapekwqqlw ervtvdlkee prtdrsqrhl srspgivstn
     1681 lpsyqkrsll hlpdssmgee qnssispsng verraatlys qytskndenr sfegtlykrg
     1741 allkgwkprw fvldvtkhql ryydsgedts ckghidlaev emvipagpsm gapkhtsdka
     1801 ffdlktskrv ynfcaqdgqs aqqwmdkiqs cisda
//
LOCUS       XP_054226060            1835 aa            linear   PRI 05-AUG-2025
DEFINITION  myotubularin-related protein 13 isoform X8 [Homo sapiens].
ACCESSION   XP_054226060
VERSION     XP_054226060.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370085.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1835
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1835
                     /product="myotubularin-related protein 13 isoform X8"
                     /calculated_mol_wt=206599
     Region          <1..38
                     /region_name="uDENN"
                     /note="uDENN domain; pfam03456"
                     /db_xref="CDD:460926"
     Region          70..252
                     /region_name="DENN"
                     /note="DENN (AEX-3) domain; pfam02141"
                     /db_xref="CDD:460461"
     Region          306..374
                     /region_name="dDENN"
                     /note="Domain always found downstream of DENN domain,
                     found in a variety of signalling proteins; smart00801"
                     /db_xref="CDD:129037"
     Region          484..708
                     /region_name="SBF2"
                     /note="Myotubularin protein; pfam12335"
                     /db_xref="CDD:463536"
     Region          836..954
                     /region_name="PH-GRAM_MTMR13"
                     /note="Myotubularian (MTM) related 13 protein Pleckstrin
                     Homology-Glucosyltransferases, Rab-like GTPase activators
                     and Myotubularins (PH-GRAM) domain; cd13339"
                     /db_xref="CDD:275416"
     Region          1092..1471
                     /region_name="PTP-MTMR13"
                     /note="protein tyrosine phosphatase-like pseudophosphatase
                     domain of myotubularin related phosphoinositide
                     phosphatase 13; cd14589"
                     /db_xref="CDD:350437"
     Region          1728..1833
                     /region_name="PH_Sbf1_hMTMR5"
                     /note="Set binding factor 1 (also called Human MTMR5)
                     Pleckstrin Homology (PH) domain; cd01235"
                     /db_xref="CDD:269941"
     CDS             1..1835
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /coded_by="XM_054370085.1:190..5697"
                     /db_xref="GeneID:81846"
                     /db_xref="HGNC:HGNC:2135"
                     /db_xref="MIM:607697"
ORIGIN      
        1 mfcqpggwql srerkqptff vvvltdidsd rhycscltfy eaeinlqgtk keeiegeakv
       61 sgliqpaevf apkslvlvsr lyypeifrac lgliytvyvd slnvslesli anlcaclvpa
      121 aggsqklfsl gagdrqliqt plhdslpitg tsvallfqql giqnvlslfc avltenkvlf
      181 hsasfqrlsd acraleslmf plkysypyip ilpaqllevl ssptpfiigv hsvfktdvhe
      241 lldviiadld ggtikipeci hlsslpepll hqtqsalsli lhpdlevadh afppprtals
      301 hskmldkevr avflrlfaql fqgyrsclql irihaepvih fhktaflgqr glvendfltk
      361 vlsgmafagf vsergppyrs cdlfdelvaf everikveen npvkmikhvr elaeqlfkne
      421 npnphmafqk vprptegshl rvhilpfpei nearvqeliq envaknqnap patriekkcv
      481 vpagppvvsi mdkvttvfns aqrlevvrnc isfifenkil etektlpaal ralkgkaarq
      541 cltdelglhv qqnraildhq qfdyiirmmn ctlqdcssle eyniaaallp ltsafyrkla
      601 pgvsqfaytc vqdhpiwtnq qfwettfyna vqeqvrslyl sakednhaph lkqkdklpdd
      661 hyqektamdl aaeqlrlwpt lskstqqelv qheestvfsq aihfanlmvn llvpldtskn
      721 kllrtsapgd wesgsnsivt nsiagsvaes ydtesgfeds entdiansvv rfitrfidkv
      781 ctesgvtqdh ikslhcmipg ivamhietle avhresrrlp piqkpkilrp allpgeeivc
      841 eglrvlldpd greeatggll ggpqllpaeg alflttyril frgtphdqlv geqtvvrsfp
      901 iasitkekki tmqnqlqqnm qeglqitsas fqlikvafde evspevveif kkqlmkfryp
      961 qsifstfafa agqttpqiil pkqkekntsf rtfsktivkg akragkmtig rqyllkkktg
     1021 tiveervnrp gwnedddvsv sdeselptst tlkasekstm eqlvekacfr dyqrlglgti
     1081 sgsssrsrpe yfritasnrm yslcrsypgl lvvpqavqds slprvarcyr hnrlpvvcwk
     1141 nsrsgtlllr sggfhgkgvv glfksqnspq aaptssless ssieqekylq allnavsvhq
     1201 klrgnstltv rpafalspgt errtsrmstv lkqvvpghld vnpsnsfaqg gvwaslrsst
     1261 rlissptsfi dvgarlagkd hsasfsnssy lqnqllkrqa alyifgeksq lrnfkvefal
     1321 ncefvpvefh eirqvkasfk klmracipst iptdsevtfl kalgdsewfp qlhrimqlav
     1381 vvsevlengs svlvcleegw ditaqvtslv qllsdpfyrt legfqmlvek ewlsfghkfs
     1441 qrssltlncq gsgfapvflq fldcvhqvhn qyptefefnl yylkflafhy vsnrfktfll
     1501 dsdyerlehg tlfddkgekh akkgvciwec idrmhkrspi ffnylysple iealkpnvnv
     1561 sslkkwdyyi eetlstgpsy dwmmltpkhf psedsdlage agprsqrrtv wpcyddvsct
     1621 qpdaltslfs eieklehkln qapekwqqlw ervtvdlkee prtdrsqrhl srspgivstn
     1681 lpsyqkrsll hlpdssmgee qnssispsng verraatlys qytskndenr sfegtlykrg
     1741 allkgwkprw fvldvtkhql ryydsgedts ckghidlaev emvipagpsm gapkhtsdka
     1801 ffdlktskrv ynfcaqdgqs aqqwmdkiqs cisda
//
LOCUS       XP_054226061            1811 aa            linear   PRI 05-AUG-2025
DEFINITION  myotubularin-related protein 13 isoform X9 [Homo sapiens].
ACCESSION   XP_054226061
VERSION     XP_054226061.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370086.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1811
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1811
                     /product="myotubularin-related protein 13 isoform X9"
                     /calculated_mol_wt=204300
     Region          1..86
                     /region_name="uDENN"
                     /note="Domain always found upstream of DENN domain, found
                     in a variety of signalling proteins; smart00800"
                     /db_xref="CDD:214824"
     Region          116..295
                     /region_name="DENN"
                     /note="DENN (AEX-3) domain; pfam02141"
                     /db_xref="CDD:460461"
     Region          314..382
                     /region_name="dDENN"
                     /note="Domain always found downstream of DENN domain,
                     found in a variety of signalling proteins; smart00801"
                     /db_xref="CDD:129037"
     Region          492..716
                     /region_name="SBF2"
                     /note="Myotubularin protein; pfam12335"
                     /db_xref="CDD:463536"
     Region          844..962
                     /region_name="PH-GRAM_MTMR13"
                     /note="Myotubularian (MTM) related 13 protein Pleckstrin
                     Homology-Glucosyltransferases, Rab-like GTPase activators
                     and Myotubularins (PH-GRAM) domain; cd13339"
                     /db_xref="CDD:275416"
     Region          1100..1447
                     /region_name="PTP-MTMR13"
                     /note="protein tyrosine phosphatase-like pseudophosphatase
                     domain of myotubularin related phosphoinositide
                     phosphatase 13; cd14589"
                     /db_xref="CDD:350437"
     Region          1704..1809
                     /region_name="PH_Sbf1_hMTMR5"
                     /note="Set binding factor 1 (also called Human MTMR5)
                     Pleckstrin Homology (PH) domain; cd01235"
                     /db_xref="CDD:269941"
     CDS             1..1811
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /coded_by="XM_054370086.1:17..5452"
                     /db_xref="GeneID:81846"
                     /db_xref="HGNC:HGNC:2135"
                     /db_xref="MIM:607697"
ORIGIN      
        1 marladyfiv vgydhekpgs geglgkiiqr fpqkdwddtp fpqgielfcq pggwqlsrer
       61 kqptffvvvl tdidsdrhyc scltfyeaei nlqgtkkeei egeakvsgli qpaevfapks
      121 lvlvsrlyyp eifraclgli ytvyvdslnv sleslianlc aclvpaaggs qklfslgagd
      181 rqliqtplhd slpitgtsva llfqqlgiqn vlslfcavlt enkvlfhsas fqrlsdacra
      241 leslmfplky sypyipilpa qllevlsspt pfiigvhsvf ktdvhelilh pdlevadhaf
      301 ppprtalshs kmldkevrav flrlfaqlfq gyrsclqlir ihaepvihfh ktaflgqrgl
      361 vendfltkvl sgmafagfvs ergppyrscd lfdelvafev erikveennp vkmikhvrel
      421 aeqlfknenp nphmafqkvp rptegshlrv hilpfpeine arvqeliqen vaknqnappa
      481 triekkcvvp agppvvsimd kvttvfnsaq rlevvrncis fifenkilet ektlpaalra
      541 lkgkaarqcl tdelglhvqq nraildhqqf dyiirmmnct lqdcssleey niaaallplt
      601 safyrklapg vsqfaytcvq dhpiwtnqqf wettfynavq eqvrslylsa kednhaphlk
      661 qkdklpddhy qektamdlaa eqlrlwptls kstqqelvqh eestvfsqai hfanlmvnll
      721 vpldtsknkl lrtsapgdwe sgsnsivtns iagsvaesyd tesgfedsen tdiansvvrf
      781 itrfidkvct esgvtqdhik slhcmipgiv amhietleav hresrrlppi qkpkilrpal
      841 lpgeeivceg lrvlldpdgr eeatggllgg pqllpaegal flttyrilfr gtphdqlvge
      901 qtvvrsfpia sitkekkitm qnqlqqnmqe glqitsasfq likvafdeev spevveifkk
      961 qlmkfrypqs ifstfafaag qttpqiilpk qkekntsfrt fsktivkgak ragkmtigrq
     1021 yllkkktgti veervnrpgw nedddvsvsd eselptsttl kasekstmeq lvekacfrdy
     1081 qrlglgtisg sssrsrpeyf ritasnrmys lcrsypgllv vpqavqdssl prvarcyrhn
     1141 rlpvvcwkns rsgtlllrsg gfhgkgvvgl fksqnspqaa ptsslessss ieqekylqal
     1201 lnavsvhqkl rgnstltvrp afalspgvwa slrsstrlis sptsfidvga rlagkdhsas
     1261 fsnssylqnq llkrqaalyi fgeksqlrnf kvefalncef vpvefheirq vkasfkklmr
     1321 acipstiptd sevtflkalg dsewfpqlhr imqlavvvse vlengssvlv cleegwdita
     1381 qvtslvqlls dpfyrtlegf qmlvekewls fghkfsqrss ltlncqgsgf apvflqfldc
     1441 vhqvhnqypt efefnlyylk flafhyvsnr fktflldsdy erlehgtlfd dkgekhakkg
     1501 vciwecidrm hkrspiffny lyspleieal kpnvnvsslk kwdyyieetl stgpsydwmm
     1561 ltpkhfpsed sdlageagpr sqrrtvwpcy ddvsctqpda ltslfseiek lehklnqape
     1621 kwqqlwervt vdlkeeprtd rsqrhlsrsp givstnlpsy qkrsllhlpd ssmgeeqnss
     1681 ispsngverr aatlysqyts kndenrsfeg tlykrgallk gwkprwfvld vtkhqlryyd
     1741 sgedtsckgh idlaevemvi pagpsmgapk htsdkaffdl ktskrvynfc aqdgqsaqqw
     1801 mdkiqscisd a
//
LOCUS       XP_054226062            1800 aa            linear   PRI 05-AUG-2025
DEFINITION  myotubularin-related protein 13 isoform X10 [Homo sapiens].
ACCESSION   XP_054226062
VERSION     XP_054226062.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370087.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1800
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1800
                     /product="myotubularin-related protein 13 isoform X10"
                     /calculated_mol_wt=203028
     Region          1..86
                     /region_name="uDENN"
                     /note="Domain always found upstream of DENN domain, found
                     in a variety of signalling proteins; smart00800"
                     /db_xref="CDD:214824"
     Region          116..295
                     /region_name="DENN"
                     /note="DENN (AEX-3) domain; pfam02141"
                     /db_xref="CDD:460461"
     Region          314..383
                     /region_name="dDENN"
                     /note="Domain always found downstream of DENN domain,
                     found in a variety of signalling proteins; smart00801"
                     /db_xref="CDD:129037"
     Region          449..673
                     /region_name="SBF2"
                     /note="Myotubularin protein; pfam12335"
                     /db_xref="CDD:463536"
     Region          801..919
                     /region_name="PH-GRAM_MTMR13"
                     /note="Myotubularian (MTM) related 13 protein Pleckstrin
                     Homology-Glucosyltransferases, Rab-like GTPase activators
                     and Myotubularins (PH-GRAM) domain; cd13339"
                     /db_xref="CDD:275416"
     Region          1057..1436
                     /region_name="PTP-MTMR13"
                     /note="protein tyrosine phosphatase-like pseudophosphatase
                     domain of myotubularin related phosphoinositide
                     phosphatase 13; cd14589"
                     /db_xref="CDD:350437"
     Region          1693..1798
                     /region_name="PH_Sbf1_hMTMR5"
                     /note="Set binding factor 1 (also called Human MTMR5)
                     Pleckstrin Homology (PH) domain; cd01235"
                     /db_xref="CDD:269941"
     CDS             1..1800
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /coded_by="XM_054370087.1:17..5419"
                     /db_xref="GeneID:81846"
                     /db_xref="HGNC:HGNC:2135"
                     /db_xref="MIM:607697"
ORIGIN      
        1 marladyfiv vgydhekpgs geglgkiiqr fpqkdwddtp fpqgielfcq pggwqlsrer
       61 kqptffvvvl tdidsdrhyc scltfyeaei nlqgtkkeei egeakvsgli qpaevfapks
      121 lvlvsrlyyp eifraclgli ytvyvdslnv sleslianlc aclvpaaggs qklfslgagd
      181 rqliqtplhd slpitgtsva llfqqlgiqn vlslfcavlt enkvlfhsas fqrlsdacra
      241 leslmfplky sypyipilpa qllevlsspt pfiigvhsvf ktdvhelilh pdlevadhaf
      301 ppprtalshs kmldkevrav flrlfaqlfq gyrsclqlir ihaepvihfh klvafeveri
      361 kveennpvkm ikhvrelaeq lfknenpnph mafqkvprpt egshlrvhil pfpeinearv
      421 qeliqenvak nqnappatri ekkcvvpagp pvvsimdkvt tvfnsaqrle vvrncisfif
      481 enkiletekt lpaalralkg kaarqcltde lglhvqqnra ildhqqfdyi irmmnctlqd
      541 cssleeynia aallpltsaf yrklapgvsq faytcvqdhp iwtnqqfwet tfynavqeqv
      601 rslylsaked nhaphlkqkd klpddhyqek tamdlaaeql rlwptlskst qqelvqhees
      661 tvfsqaihfa nlmvnllvpl dtsknkllrt sapgdwesgs nsivtnsiag svaesydtes
      721 gfedsentdi ansvvrfitr fidkvctesg vtqdhikslh cmipgivamh ietleavhre
      781 srrlppiqkp kilrpallpg eeivceglrv lldpdgreea tggllggpql lpaegalflt
      841 tyrilfrgtp hdqlvgeqtv vrsfpiasit kekkitmqnq lqqnmqeglq itsasfqlik
      901 vafdeevspe vveifkkqlm kfrypqsifs tfafaagqtt pqiilpkqke kntsfrtfsk
      961 tivkgakrag kmtigrqyll kkktgtivee rvnrpgwned ddvsvsdese lptsttlkas
     1021 ekstmeqlve kacfrdyqrl glgtisgsss rsrpeyfrit asnrmyslcr sypgllvvpq
     1081 avqdsslprv arcyrhnrlp vvcwknsrsg tlllrsggfh gkgvvglfks qnspqaapts
     1141 slessssieq ekylqallna vsvhqklrgn stltvrpafa lspgterrts rmstvlkqvv
     1201 pghldvnpsn sfaqggvwas lrsstrliss ptsfidvgar lagkdhsasf snssylqnql
     1261 lkrqaalyif geksqlrnfk vefalncefv pvefheirqv kasfkklmra cipstiptds
     1321 evtflkalgd sewfpqlhri mqlavvvsev lengssvlvc leegwditaq vtslvqllsd
     1381 pfyrtlegfq mlvekewlsf ghkfsqrssl tlncqgsgfa pvflqfldcv hqvhnqypte
     1441 fefnlyylkf lafhyvsnrf ktflldsdye rlehgtlfdd kgekhakkgv ciwecidrmh
     1501 krspiffnyl yspleiealk pnvnvsslkk wdyyieetls tgpsydwmml tpkhfpseds
     1561 dlageagprs qrrtvwpcyd dvsctqpdal tslfseiekl ehklnqapek wqqlwervtv
     1621 dlkeeprtdr sqrhlsrspg ivstnlpsyq krsllhlpds smgeeqnssi spsngverra
     1681 atlysqytsk ndenrsfegt lykrgallkg wkprwfvldv tkhqlryyds gedtsckghi
     1741 dlaevemvip agpsmgapkh tsdkaffdlk tskrvynfca qdgqsaqqwm dkiqscisda
//
LOCUS       XP_054226063            1554 aa            linear   PRI 05-AUG-2025
DEFINITION  myotubularin-related protein 13 isoform X1 [Homo sapiens].
ACCESSION   XP_054226063
VERSION     XP_054226063.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370088.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1554
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1554
                     /product="myotubularin-related protein 13 isoform X1"
                     /calculated_mol_wt=173958
     Region          1..86
                     /region_name="uDENN"
                     /note="Domain always found upstream of DENN domain, found
                     in a variety of signalling proteins; smart00800"
                     /db_xref="CDD:214824"
     Region          116..298
                     /region_name="DENN"
                     /note="DENN (AEX-3) domain; pfam02141"
                     /db_xref="CDD:460461"
     Region          352..420
                     /region_name="dDENN"
                     /note="Domain always found downstream of DENN domain,
                     found in a variety of signalling proteins; smart00801"
                     /db_xref="CDD:129037"
     Region          530..754
                     /region_name="SBF2"
                     /note="Myotubularin protein; pfam12335"
                     /db_xref="CDD:463536"
     Region          882..1000
                     /region_name="PH-like"
                     /note="Pleckstrin homology-like domain; cl17171"
                     /db_xref="CDD:473070"
     Region          1138..1513
                     /region_name="PTP_DSP_cys"
                     /note="cys-based protein tyrosine phosphatase and
                     dual-specificity phosphatase superfamily; cl28904"
                     /db_xref="CDD:475123"
     CDS             1..1554
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /coded_by="XM_054370088.1:153..4817"
                     /db_xref="GeneID:81846"
                     /db_xref="HGNC:HGNC:2135"
                     /db_xref="MIM:607697"
ORIGIN      
        1 marladyfiv vgydhekpgs geglgkiiqr fpqkdwddtp fpqgielfcq pggwqlsrer
       61 kqptffvvvl tdidsdrhyc scltfyeaei nlqgtkkeei egeakvsgli qpaevfapks
      121 lvlvsrlyyp eifraclgli ytvyvdslnv sleslianlc aclvpaaggs qklfslgagd
      181 rqliqtplhd slpitgtsva llfqqlgiqn vlslfcavlt enkvlfhsas fqrlsdacra
      241 leslmfplky sypyipilpa qllevlsspt pfiigvhsvf ktdvhelldv iiadldggti
      301 kipecihlss lpepllhqtq salslilhpd levadhafpp prtalshskm ldkevravfl
      361 rlfaqlfqgy rsclqlirih aepvihfhkt aflgqrglve ndfltkvlsg mafagfvser
      421 gppyrscdlf delvafever ikveennpvk mikhvrelae qlfknenpnp hmafqkvprp
      481 tegshlrvhi lpfpeinear vqeliqenva knqnappatr iekkcvvpag ppvvsimdkv
      541 ttvfnsaqrl evvrncisfi fenkiletek tlpaalralk gkaarqcltd elglhvqqnr
      601 aildhqqfdy iirmmnctlq dcssleeyni aaallpltsa fyrklapgvs qfaytcvqdh
      661 piwtnqqfwe ttfynavqeq vrslylsake dnhaphlkqk dklpddhyqe ktamdlaaeq
      721 lrlwptlsks tqqelvqhee stvfsqaihf anlmvnllvp ldtsknkllr tsapgdwesg
      781 snsivtnsia gsvaesydte sgfedsentd iansvvrfit rfidkvctes gvtqdhiksl
      841 hcmipgivam hietleavhr esrrlppiqk pkilrpallp geeivceglr vlldpdgree
      901 atggllggpq llpaegalfl ttyrilfrgt phdqlvgeqt vvrsfpiasi tkekkitmqn
      961 qlqqnmqegl qitsasfqli kvafdeevsp evveifkkql mkfrypqsif stfafaagqt
     1021 tpqiilpkqk ekntsfrtfs ktivkgakra gkmtigrqyl lkkktgtive ervnrpgwne
     1081 dddvsvsdes elptsttlka sekstmeqlv ekacfrdyqr lglgtisgss srsrpeyfri
     1141 tasnrmyslc rsypgllvvp qavqdsslpr varcyrhnrl pvvcwknsrs gtlllrsggf
     1201 hgkgvvglfk sqnspqaapt sslessssie qekylqalln avsvhqklrg nstltvrpaf
     1261 alspgterrt srmstvlkqv vpghldvnps nsfaqggvwa slrsstrlis sptsfidvga
     1321 rlagkdhsas fsnssylqnq llkrqaalyi fgeksqlrnf kvefalncef vpvefheirq
     1381 vkasfkklmr acipstiptd sevtflkalg dsewfpqlhr imqlavvvse vlengssvlv
     1441 cleegwdita qvtslvqlls dpfyrtlegf qmlvekewls fghkfsqrss ltlncqgsgf
     1501 apvflqfldc vhqelylmik eksmpkkesv fgnvltectr gvpfsliiyi hhwk
//
LOCUS       XP_054226064            1267 aa            linear   PRI 05-AUG-2025
DEFINITION  myotubularin-related protein 13 isoform X2 [Homo sapiens].
ACCESSION   XP_054226064
VERSION     XP_054226064.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370089.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1267
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1267
                     /product="myotubularin-related protein 13 isoform X2"
                     /calculated_mol_wt=141583
     Region          1..86
                     /region_name="uDENN"
                     /note="Domain always found upstream of DENN domain, found
                     in a variety of signalling proteins; smart00800"
                     /db_xref="CDD:214824"
     Region          116..298
                     /region_name="DENN"
                     /note="DENN (AEX-3) domain; pfam02141"
                     /db_xref="CDD:460461"
     Region          352..420
                     /region_name="dDENN"
                     /note="Domain always found downstream of DENN domain,
                     found in a variety of signalling proteins; smart00801"
                     /db_xref="CDD:129037"
     Region          530..754
                     /region_name="SBF2"
                     /note="Myotubularin protein; pfam12335"
                     /db_xref="CDD:463536"
     Region          882..1000
                     /region_name="PH-like"
                     /note="Pleckstrin homology-like domain; cl17171"
                     /db_xref="CDD:473070"
     Region          1138..>1254
                     /region_name="PTP_DSP_cys"
                     /note="cys-based protein tyrosine phosphatase and
                     dual-specificity phosphatase superfamily; cl28904"
                     /db_xref="CDD:475123"
     CDS             1..1267
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /coded_by="XM_054370089.1:153..3956"
                     /db_xref="GeneID:81846"
                     /db_xref="HGNC:HGNC:2135"
                     /db_xref="MIM:607697"
ORIGIN      
        1 marladyfiv vgydhekpgs geglgkiiqr fpqkdwddtp fpqgielfcq pggwqlsrer
       61 kqptffvvvl tdidsdrhyc scltfyeaei nlqgtkkeei egeakvsgli qpaevfapks
      121 lvlvsrlyyp eifraclgli ytvyvdslnv sleslianlc aclvpaaggs qklfslgagd
      181 rqliqtplhd slpitgtsva llfqqlgiqn vlslfcavlt enkvlfhsas fqrlsdacra
      241 leslmfplky sypyipilpa qllevlsspt pfiigvhsvf ktdvhelldv iiadldggti
      301 kipecihlss lpepllhqtq salslilhpd levadhafpp prtalshskm ldkevravfl
      361 rlfaqlfqgy rsclqlirih aepvihfhkt aflgqrglve ndfltkvlsg mafagfvser
      421 gppyrscdlf delvafever ikveennpvk mikhvrelae qlfknenpnp hmafqkvprp
      481 tegshlrvhi lpfpeinear vqeliqenva knqnappatr iekkcvvpag ppvvsimdkv
      541 ttvfnsaqrl evvrncisfi fenkiletek tlpaalralk gkaarqcltd elglhvqqnr
      601 aildhqqfdy iirmmnctlq dcssleeyni aaallpltsa fyrklapgvs qfaytcvqdh
      661 piwtnqqfwe ttfynavqeq vrslylsake dnhaphlkqk dklpddhyqe ktamdlaaeq
      721 lrlwptlsks tqqelvqhee stvfsqaihf anlmvnllvp ldtsknkllr tsapgdwesg
      781 snsivtnsia gsvaesydte sgfedsentd iansvvrfit rfidkvctes gvtqdhiksl
      841 hcmipgivam hietleavhr esrrlppiqk pkilrpallp geeivceglr vlldpdgree
      901 atggllggpq llpaegalfl ttyrilfrgt phdqlvgeqt vvrsfpiasi tkekkitmqn
      961 qlqqnmqegl qitsasfqli kvafdeevsp evveifkkql mkfrypqsif stfafaagqt
     1021 tpqiilpkqk ekntsfrtfs ktivkgakra gkmtigrqyl lkkktgtive ervnrpgwne
     1081 dddvsvsdes elptsttlka sekstmeqlv ekacfrdyqr lglgtisgss srsrpeyfri
     1141 tasnrmyslc rsypgllvvp qavqdsslpr varcyrhnrl pvvcwknsrs gtlllrsggf
     1201 hgkgvvglfk sqnspqaapt sslessssie qekylqalln avsvhqklrg nstltvrpaf
     1261 alspvim
//
LOCUS       XP_054226065            1159 aa            linear   PRI 05-AUG-2025
DEFINITION  myotubularin-related protein 13 isoform X3 [Homo sapiens].
ACCESSION   XP_054226065
VERSION     XP_054226065.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370090.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1159
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1159
                     /product="myotubularin-related protein 13 isoform X3"
                     /calculated_mol_wt=129912
     Region          1..86
                     /region_name="uDENN"
                     /note="Domain always found upstream of DENN domain, found
                     in a variety of signalling proteins; smart00800"
                     /db_xref="CDD:214824"
     Region          116..298
                     /region_name="DENN"
                     /note="DENN (AEX-3) domain; pfam02141"
                     /db_xref="CDD:460461"
     Region          352..420
                     /region_name="dDENN"
                     /note="Domain always found downstream of DENN domain,
                     found in a variety of signalling proteins; smart00801"
                     /db_xref="CDD:129037"
     Region          530..754
                     /region_name="SBF2"
                     /note="Myotubularin protein; pfam12335"
                     /db_xref="CDD:463536"
     Region          882..1000
                     /region_name="PH-like"
                     /note="Pleckstrin homology-like domain; cl17171"
                     /db_xref="CDD:473070"
     CDS             1..1159
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /coded_by="XM_054370090.1:153..3632"
                     /db_xref="GeneID:81846"
                     /db_xref="HGNC:HGNC:2135"
                     /db_xref="MIM:607697"
ORIGIN      
        1 marladyfiv vgydhekpgs geglgkiiqr fpqkdwddtp fpqgielfcq pggwqlsrer
       61 kqptffvvvl tdidsdrhyc scltfyeaei nlqgtkkeei egeakvsgli qpaevfapks
      121 lvlvsrlyyp eifraclgli ytvyvdslnv sleslianlc aclvpaaggs qklfslgagd
      181 rqliqtplhd slpitgtsva llfqqlgiqn vlslfcavlt enkvlfhsas fqrlsdacra
      241 leslmfplky sypyipilpa qllevlsspt pfiigvhsvf ktdvhelldv iiadldggti
      301 kipecihlss lpepllhqtq salslilhpd levadhafpp prtalshskm ldkevravfl
      361 rlfaqlfqgy rsclqlirih aepvihfhkt aflgqrglve ndfltkvlsg mafagfvser
      421 gppyrscdlf delvafever ikveennpvk mikhvrelae qlfknenpnp hmafqkvprp
      481 tegshlrvhi lpfpeinear vqeliqenva knqnappatr iekkcvvpag ppvvsimdkv
      541 ttvfnsaqrl evvrncisfi fenkiletek tlpaalralk gkaarqcltd elglhvqqnr
      601 aildhqqfdy iirmmnctlq dcssleeyni aaallpltsa fyrklapgvs qfaytcvqdh
      661 piwtnqqfwe ttfynavqeq vrslylsake dnhaphlkqk dklpddhyqe ktamdlaaeq
      721 lrlwptlsks tqqelvqhee stvfsqaihf anlmvnllvp ldtsknkllr tsapgdwesg
      781 snsivtnsia gsvaesydte sgfedsentd iansvvrfit rfidkvctes gvtqdhiksl
      841 hcmipgivam hietleavhr esrrlppiqk pkilrpallp geeivceglr vlldpdgree
      901 atggllggpq llpaegalfl ttyrilfrgt phdqlvgeqt vvrsfpiasi tkekkitmqn
      961 qlqqnmqegl qitsasfqli kvafdeevsp evveifkkql mkfrypqsif stfafaagqt
     1021 tpqiilpkqk ekntsfrtfs ktivkgakra gkmtigrqyl lkkktgtive ervnrpgwne
     1081 dddvsvsdes elptsttlka sekstmeqlv ekacfrdyqr lglgtisgss srsrpeyfri
     1141 tasnrmyslc rspeidkna
//
LOCUS       XP_054226066            1116 aa            linear   PRI 05-AUG-2025
DEFINITION  myotubularin-related protein 13 isoform X4 [Homo sapiens].
ACCESSION   XP_054226066
VERSION     XP_054226066.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370091.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1116
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1116
                     /product="myotubularin-related protein 13 isoform X4"
                     /calculated_mol_wt=125187
     Region          1..86
                     /region_name="uDENN"
                     /note="Domain always found upstream of DENN domain, found
                     in a variety of signalling proteins; smart00800"
                     /db_xref="CDD:214824"
     Region          116..298
                     /region_name="DENN"
                     /note="DENN (AEX-3) domain; pfam02141"
                     /db_xref="CDD:460461"
     Region          352..421
                     /region_name="dDENN"
                     /note="Domain always found downstream of DENN domain,
                     found in a variety of signalling proteins; smart00801"
                     /db_xref="CDD:129037"
     Region          487..711
                     /region_name="SBF2"
                     /note="Myotubularin protein; pfam12335"
                     /db_xref="CDD:463536"
     Region          839..957
                     /region_name="PH-like"
                     /note="Pleckstrin homology-like domain; cl17171"
                     /db_xref="CDD:473070"
     CDS             1..1116
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /coded_by="XM_054370091.1:17..3367"
                     /db_xref="GeneID:81846"
                     /db_xref="HGNC:HGNC:2135"
                     /db_xref="MIM:607697"
ORIGIN      
        1 marladyfiv vgydhekpgs geglgkiiqr fpqkdwddtp fpqgielfcq pggwqlsrer
       61 kqptffvvvl tdidsdrhyc scltfyeaei nlqgtkkeei egeakvsgli qpaevfapks
      121 lvlvsrlyyp eifraclgli ytvyvdslnv sleslianlc aclvpaaggs qklfslgagd
      181 rqliqtplhd slpitgtsva llfqqlgiqn vlslfcavlt enkvlfhsas fqrlsdacra
      241 leslmfplky sypyipilpa qllevlsspt pfiigvhsvf ktdvhelldv iiadldggti
      301 kipecihlss lpepllhqtq salslilhpd levadhafpp prtalshskm ldkevravfl
      361 rlfaqlfqgy rsclqlirih aepvihfhkl vafeverikv eennpvkmik hvrelaeqlf
      421 knenpnphma fqkvprpteg shlrvhilpf peinearvqe liqenvaknq nappatriek
      481 kcvvpagppv vsimdkvttv fnsaqrlevv rncisfifen kiletektlp aalralkgka
      541 arqcltdelg lhvqqnrail dhqqfdyiir mmnctlqdcs sleeyniaaa llpltsafyr
      601 klapgvsqfa ytcvqdhpiw tnqqfwettf ynavqeqvrs lylsakednh aphlkqkdkl
      661 pddhyqekta mdlaaeqlrl wptlskstqq elvqheestv fsqaihfanl mvnllvpldt
      721 sknkllrtsa pgdwesgsns ivtnsiagsv aesydtesgf edsentdian svvrfitrfi
      781 dkvctesgvt qdhikslhcm ipgivamhie tleavhresr rlppiqkpki lrpallpgee
      841 ivceglrvll dpdgreeatg gllggpqllp aegalfltty rilfrgtphd qlvgeqtvvr
      901 sfpiasitke kkitmqnqlq qnmqeglqit sasfqlikva fdeevspevv eifkkqlmkf
      961 rypqsifstf afaagqttpq iilpkqkekn tsfrtfskti vkgakragkm tigrqyllkk
     1021 ktgtiveerv nrpgwneddd vsvsdeselp tsttlkasek stmeqlveka cfrdyqrlgl
     1081 gtisgsssrs rpeyfritas nrmyslcrsp eidkna
//
LOCUS       XP_054226067            1105 aa            linear   PRI 05-AUG-2025
DEFINITION  myotubularin-related protein 13 isoform X5 [Homo sapiens].
ACCESSION   XP_054226067
VERSION     XP_054226067.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370092.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1105
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1105
                     /product="myotubularin-related protein 13 isoform X5"
                     /calculated_mol_wt=123619
     Region          1..86
                     /region_name="uDENN"
                     /note="Domain always found upstream of DENN domain, found
                     in a variety of signalling proteins; smart00800"
                     /db_xref="CDD:214824"
     Region          116..298
                     /region_name="DENN"
                     /note="DENN (AEX-3) domain; pfam02141"
                     /db_xref="CDD:460461"
     Region          352..420
                     /region_name="dDENN"
                     /note="Domain always found downstream of DENN domain,
                     found in a variety of signalling proteins; smart00801"
                     /db_xref="CDD:129037"
     Region          530..754
                     /region_name="SBF2"
                     /note="Myotubularin protein; pfam12335"
                     /db_xref="CDD:463536"
     Region          882..1000
                     /region_name="PH-like"
                     /note="Pleckstrin homology-like domain; cl17171"
                     /db_xref="CDD:473070"
     CDS             1..1105
                     /gene="SBF2"
                     /gene_synonym="CMT4B2; DENND7B; MTMR13"
                     /coded_by="XM_054370092.1:138..3455"
                     /db_xref="GeneID:81846"
                     /db_xref="HGNC:HGNC:2135"
                     /db_xref="MIM:607697"
ORIGIN      
        1 marladyfiv vgydhekpgs geglgkiiqr fpqkdwddtp fpqgielfcq pggwqlsrer
       61 kqptffvvvl tdidsdrhyc scltfyeaei nlqgtkkeei egeakvsgli qpaevfapks
      121 lvlvsrlyyp eifraclgli ytvyvdslnv sleslianlc aclvpaaggs qklfslgagd
      181 rqliqtplhd slpitgtsva llfqqlgiqn vlslfcavlt enkvlfhsas fqrlsdacra
      241 leslmfplky sypyipilpa qllevlsspt pfiigvhsvf ktdvhelldv iiadldggti
      301 kipecihlss lpepllhqtq salslilhpd levadhafpp prtalshskm ldkevravfl
      361 rlfaqlfqgy rsclqlirih aepvihfhkt aflgqrglve ndfltkvlsg mafagfvser
      421 gppyrscdlf delvafever ikveennpvk mikhvrelae qlfknenpnp hmafqkvprp
      481 tegshlrvhi lpfpeinear vqeliqenva knqnappatr iekkcvvpag ppvvsimdkv
      541 ttvfnsaqrl evvrncisfi fenkiletek tlpaalralk gkaarqcltd elglhvqqnr
      601 aildhqqfdy iirmmnctlq dcssleeyni aaallpltsa fyrklapgvs qfaytcvqdh
      661 piwtnqqfwe ttfynavqeq vrslylsake dnhaphlkqk dklpddhyqe ktamdlaaeq
      721 lrlwptlsks tqqelvqhee stvfsqaihf anlmvnllvp ldtsknkllr tsapgdwesg
      781 snsivtnsia gsvaesydte sgfedsentd iansvvrfit rfidkvctes gvtqdhiksl
      841 hcmipgivam hietleavhr esrrlppiqk pkilrpallp geeivceglr vlldpdgree
      901 atggllggpq llpaegalfl ttyrilfrgt phdqlvgeqt vvrsfpiasi tkekkitmqn
      961 qlqqnmqegl qitsasfqli kvafdeevsp evveifkkql mkfrypqsif stfafaagqt
     1021 tpqiilpkqk ekntsfrtfs ktivkgakra gkmtigrqyl lkkktgtive ervnrpgwne
     1081 dddvsvsdes elptgttlka sials
//
LOCUS       XP_054226068             898 aa            linear   PRI 05-AUG-2025
DEFINITION  kinesin-like protein KIF18A isoform X1 [Homo sapiens].
ACCESSION   XP_054226068
VERSION     XP_054226068.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370093.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..898
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..898
                     /product="kinesin-like protein KIF18A isoform X1"
                     /calculated_mol_wt=102150
     Region          11..355
                     /region_name="KISc_KIP3_like"
                     /note="Kinesin motor domain, KIP3-like subgroup; cd01370"
                     /db_xref="CDD:276821"
     Site            order(19,113,116,118..121,258)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276821"
     Site            order(308,311,314)
                     /site_type="other"
                     /note="microtubule interaction site [polypeptide binding]"
                     /db_xref="CDD:276821"
     CDS             1..898
                     /gene="KIF18A"
                     /gene_synonym="MS-KIF18A; PPP1R99"
                     /coded_by="XM_054370093.1:737..3433"
                     /db_xref="GeneID:81930"
                     /db_xref="HGNC:HGNC:29441"
                     /db_xref="MIM:611271"
ORIGIN      
        1 msvteedlch hmkvvvrvrp entkekaagf hkvvhvvdkh ilvfdpkqee vsffhgkktt
       61 nqnvikkqnk dlkfvfdavf detstqsevf ehttkpilrs flngynctvl aygatgagkt
      121 htmlgsadep gvmyltmlhl ykcmdeikee kicstavsyl evyneqirdl lvnsgplavr
      181 edtqkgvvvh gltlhqpkss eeilhlldng nknrtqhptd mnatssrsha vfqiylrqqd
      241 ktasinqnvr iakmslidla gserastsga kgtrfvegtn inrsllalgn vinaladskr
      301 knqhipyrns kltrllkdsl ggncqtimia avspssvfyd dtyntlkyan rakdiksslk
      361 snvlnvnnhi tqyvkicneq kaeilllkek lkayeeqkaf tnendqaklm isnpqekeie
      421 rfqeilnclf qnreeirqey lklemllken elksfyqqqc hkqiemmcse dkvekatgkr
      481 dhrlamlktr rsylekrree elkqfdentn wlhrvekemg llsqnghipk elkkdlhchh
      541 lhlqnkdlka qirhmmdlac lqeqqhrqte avlnallptl rkqyctlkea glsnaafesd
      601 fkeiehlver kkvvvwadqt aeqpkqndlp gisvlmtfpq lgpvqpipcc sssggtnlvk
      661 iptekrtrrk lmpsplkgqh tlksppsqsv qlndslskel qpivytpedc rkafqnpstv
      721 tlmkpssftt sfqaissnin sdnclkmlce vaiphnrrke cgqedldstf ticedikssk
      781 cklpeqeslp ndnkdilqrl dpssfstkhs mpvpsmvpsy mamttaakrk rkltsstsns
      841 sltadvnsgf akrvrqdnss ekhlqenkpt mehkrnicki npsmvrkfgr niskgnlr
//
LOCUS       XP_054226069             454 aa            linear   PRI 05-AUG-2025
DEFINITION  kinesin-like protein KIF18A isoform X2 [Homo sapiens].
ACCESSION   XP_054226069
VERSION     XP_054226069.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370094.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..454
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..454
                     /product="kinesin-like protein KIF18A isoform X2"
                     /calculated_mol_wt=51801
     CDS             1..454
                     /gene="KIF18A"
                     /gene_synonym="MS-KIF18A; PPP1R99"
                     /coded_by="XM_054370094.1:232..1596"
                     /db_xref="GeneID:81930"
                     /db_xref="HGNC:HGNC:29441"
                     /db_xref="MIM:611271"
ORIGIN      
        1 mllkenelks fyqqqchkqi emmcsedkve katgkrdhrl amlktrrsyl ekrreeelkq
       61 fdentnwlhr vekemgllsq nghipkelkk dlhchhlhlq nkdlkaqirh mmdlaclqeq
      121 qhrqteavln allptlrkqy ctlkeaglsn aafesdfkei ehlverkkvv vwadqtaeqp
      181 kqndlpgisv lmtfpqlgpv qpipccsssg gtnlvkipte krtrrklmps plkgqhtlks
      241 ppsqsvqlnd slskelqpiv ytpedcrkaf qnpstvtlmk pssfttsfqa issninsdnc
      301 lkmlcevaip hnrrkecgqe dldstftice diksskcklp eqeslpndnk dilqrldpss
      361 fstkhsmpvp smvpsymamt taakrkrklt sstsnsslta dvnsgfakrv rqdnssekhl
      421 qenkptmehk rnickinpsm vrkfgrnisk gnlr
//
LOCUS       XP_054226070             714 aa            linear   PRI 05-AUG-2025
DEFINITION  calpain-1 catalytic subunit isoform X1 [Homo sapiens].
ACCESSION   XP_054226070
VERSION     XP_054226070.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370095.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..714
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..714
                     /product="calpain-1 catalytic subunit isoform X1"
                     /calculated_mol_wt=81700
     Region          56..352
                     /region_name="Peptidase_C2"
                     /note="Calpain family cysteine protease; pfam00648"
                     /db_xref="CDD:459889"
     Region          364..524
                     /region_name="Calpain_III"
                     /note="Calpain, subdomain III. Calpains are
                     calcium-activated cytoplasmic cysteine proteinases,
                     participate in cytoskeletal remodeling processes, cell
                     differentiation, apoptosis and signal transduction.
                     Catalytic domain and the two calmodulin-like domains
                     are...; cd00214"
                     /db_xref="CDD:238132"
     Site            order(402..404,417)
                     /site_type="other"
                     /note="acidic loop"
                     /db_xref="CDD:238132"
     Region          546..714
                     /region_name="EFh_PEF_CAPN1"
                     /note="Penta-EF hand, calcium binding motifs, found in
                     mu-type calpain (CAPN1); cd16198"
                     /db_xref="CDD:320073"
     Region          546..574
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320073"
     Site            order(558..560,565,583,598,600,602,609,628,630,632,639,
                     671,673..674)
                     /site_type="other"
                     /note="Ca binding site [ion binding]"
                     /db_xref="CDD:320073"
     Region          589..618
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320073"
     Region          619..649
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320073"
     Region          655..683
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320073"
     Region          685..714
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320073"
     CDS             1..714
                     /gene="CAPN1"
                     /gene_synonym="CANP; CANP1; CANPL1; muCANP; muCL; SPG76"
                     /coded_by="XM_054370095.1:99..2243"
                     /db_xref="GeneID:823"
                     /db_xref="HGNC:HGNC:1476"
                     /db_xref="MIM:114220"
ORIGIN      
        1 mseeiitpvy ctgvsaqvqk qrarelglgr henaikylgq dyeqlrvrcl qsgtlfrdea
       61 fppvpqslgy kdlgpnsskt ygikwkrpte llsnpqfivd gatrtdicqg algdcwllaa
      121 iasltlndtl lhrvvphgqs fqngyagifh fqlwqfgewv dvvvddllpi kdgklvfvhs
      181 aegnefwsal lekayakvng syealsggst segfedftgg vtewyelrka psdlyqiilk
      241 alergsllgc sidissvldm eaitfkklvk ghaysvtgak qvnyrgqvvs lirmrnpwge
      301 vewtgawsds ssewnnvdpy erdqlrvkme dgefwmsfrd fmreftrlei cnltpdalks
      361 rtirkwnttl yegtwrrgst aggcrnypat fwvnpqfkir ldetddpddy gdresgcsfv
      421 lalmqkhrrr erpfgrdmet igfavyevpp elvgqpavhl krdfflanas rarseqfinl
      481 revstrfrlp pgeyvvvpst fepnkegdfv lrffseksag tvelddqiqa nlpdeqvlse
      541 eeidenfkal frqlagedme isvkelrtil nriiskhkdl rtkgfslesc rsmvnlmdrd
      601 gngklglvef nilwnrirny lsifrkfdld ksgsmsayem rmaiesagfk lnkklyelii
      661 trysepdlav dfdnfvcclv rletmfrffk tldtdldgvv tfdlfkwlql tmfa
//
LOCUS       XP_054226071             714 aa            linear   PRI 05-AUG-2025
DEFINITION  calpain-1 catalytic subunit isoform X1 [Homo sapiens].
ACCESSION   XP_054226071
VERSION     XP_054226071.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370096.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..714
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..714
                     /product="calpain-1 catalytic subunit isoform X1"
                     /calculated_mol_wt=81700
     Region          56..352
                     /region_name="Peptidase_C2"
                     /note="Calpain family cysteine protease; pfam00648"
                     /db_xref="CDD:459889"
     Region          364..524
                     /region_name="Calpain_III"
                     /note="Calpain, subdomain III. Calpains are
                     calcium-activated cytoplasmic cysteine proteinases,
                     participate in cytoskeletal remodeling processes, cell
                     differentiation, apoptosis and signal transduction.
                     Catalytic domain and the two calmodulin-like domains
                     are...; cd00214"
                     /db_xref="CDD:238132"
     Site            order(402..404,417)
                     /site_type="other"
                     /note="acidic loop"
                     /db_xref="CDD:238132"
     Region          546..714
                     /region_name="EFh_PEF_CAPN1"
                     /note="Penta-EF hand, calcium binding motifs, found in
                     mu-type calpain (CAPN1); cd16198"
                     /db_xref="CDD:320073"
     Region          546..574
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320073"
     Site            order(558..560,565,583,598,600,602,609,628,630,632,639,
                     671,673..674)
                     /site_type="other"
                     /note="Ca binding site [ion binding]"
                     /db_xref="CDD:320073"
     Region          589..618
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320073"
     Region          619..649
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320073"
     Region          655..683
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320073"
     Region          685..714
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320073"
     CDS             1..714
                     /gene="CAPN1"
                     /gene_synonym="CANP; CANP1; CANPL1; muCANP; muCL; SPG76"
                     /coded_by="XM_054370096.1:110..2254"
                     /db_xref="GeneID:823"
                     /db_xref="HGNC:HGNC:1476"
                     /db_xref="MIM:114220"
ORIGIN      
        1 mseeiitpvy ctgvsaqvqk qrarelglgr henaikylgq dyeqlrvrcl qsgtlfrdea
       61 fppvpqslgy kdlgpnsskt ygikwkrpte llsnpqfivd gatrtdicqg algdcwllaa
      121 iasltlndtl lhrvvphgqs fqngyagifh fqlwqfgewv dvvvddllpi kdgklvfvhs
      181 aegnefwsal lekayakvng syealsggst segfedftgg vtewyelrka psdlyqiilk
      241 alergsllgc sidissvldm eaitfkklvk ghaysvtgak qvnyrgqvvs lirmrnpwge
      301 vewtgawsds ssewnnvdpy erdqlrvkme dgefwmsfrd fmreftrlei cnltpdalks
      361 rtirkwnttl yegtwrrgst aggcrnypat fwvnpqfkir ldetddpddy gdresgcsfv
      421 lalmqkhrrr erpfgrdmet igfavyevpp elvgqpavhl krdfflanas rarseqfinl
      481 revstrfrlp pgeyvvvpst fepnkegdfv lrffseksag tvelddqiqa nlpdeqvlse
      541 eeidenfkal frqlagedme isvkelrtil nriiskhkdl rtkgfslesc rsmvnlmdrd
      601 gngklglvef nilwnrirny lsifrkfdld ksgsmsayem rmaiesagfk lnkklyelii
      661 trysepdlav dfdnfvcclv rletmfrffk tldtdldgvv tfdlfkwlql tmfa
//
LOCUS       XP_054226072             686 aa            linear   PRI 05-AUG-2025
DEFINITION  phosphatidylinositol-binding clathrin assembly protein isoform X1
            [Homo sapiens].
ACCESSION   XP_054226072
VERSION     XP_054226072.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370097.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 24% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..686
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..686
                     /product="phosphatidylinositol-binding clathrin assembly
                     protein isoform X1"
                     /calculated_mol_wt=74203
     Region          24..282
                     /region_name="ANTH"
                     /note="ANTH domain; pfam07651"
                     /db_xref="CDD:400137"
     Site            order(28,38,40..41)
                     /site_type="other"
                     /note="PtdIns(4,5)P2-binding site [chemical binding]"
                     /db_xref="CDD:340782"
     CDS             1..686
                     /gene="PICALM"
                     /gene_synonym="CALM; CLTH; LAP"
                     /coded_by="XM_054370097.1:305..2365"
                     /db_xref="GeneID:8301"
                     /db_xref="HGNC:HGNC:15514"
                     /db_xref="MIM:603025"
ORIGIN      
        1 msgqsltdri taaqhsvtgs avsktvckat theimgpkkk hldyliqctn emnvnipqla
       61 dslferttns swvvvfksli tthhlmvygn erfiqylasr ntlfnlsnfl dksglqgydm
      121 stfirrysry lnekavsyrq vafdftkvkr gadgvmrtmn tekllktvpi iqnqmdalld
      181 fnvnsneltn gvinaafmll fkdairlfaa ynegiinlle kyfdmkknqc kegldiykkf
      241 ltrmtrisef lkvaeqvgid rgdipdlsqa psslldaleq hlaslegkki kdstaasrat
      301 tlsnavssla stglsltkvd erekqaalee eqarlkalke qrlkelakkp htslttaasp
      361 vstsaggimt apaidifstp sssnstsklp ndlldlqqpt fhpsvhpmst asqvastwgd
      421 pfsatvdavd daipslnpfl tkssgdvhls issdvstftt rtpthemfvg ftpspvaqph
      481 psaglnvdfe svfgnkstnv ivdsggfdel ggllkptvas qnqnlpvakl ppsklvsddl
      541 dsslanlvgn lgigngttkn dvnwsqpgek kltggsnwqp kvapttawna atmngmhfpq
      601 yappvmaypa ttptgmigyg ippqmgsvpv mtqptliysq pvmrppnpfg pvsgaqlsaa
      661 sspsshsphr asgkdpfael sledfl
//
LOCUS       XP_054226073             660 aa            linear   PRI 05-AUG-2025
DEFINITION  phosphatidylinositol-binding clathrin assembly protein isoform X2
            [Homo sapiens].
ACCESSION   XP_054226073
VERSION     XP_054226073.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370098.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..660
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..660
                     /product="phosphatidylinositol-binding clathrin assembly
                     protein isoform X2"
                     /calculated_mol_wt=71599
     Region          24..282
                     /region_name="ANTH"
                     /note="ANTH domain; pfam07651"
                     /db_xref="CDD:400137"
     Site            order(28,38,40..41)
                     /site_type="other"
                     /note="PtdIns(4,5)P2-binding site [chemical binding]"
                     /db_xref="CDD:340782"
     CDS             1..660
                     /gene="PICALM"
                     /gene_synonym="CALM; CLTH; LAP"
                     /coded_by="XM_054370098.1:305..2287"
                     /db_xref="GeneID:8301"
                     /db_xref="HGNC:HGNC:15514"
                     /db_xref="MIM:603025"
ORIGIN      
        1 msgqsltdri taaqhsvtgs avsktvckat theimgpkkk hldyliqctn emnvnipqla
       61 dslferttns swvvvfksli tthhlmvygn erfiqylasr ntlfnlsnfl dksglqgydm
      121 stfirrysry lnekavsyrq vafdftkvkr gadgvmrtmn tekllktvpi iqnqmdalld
      181 fnvnsneltn gvinaafmll fkdairlfaa ynegiinlle kyfdmkknqc kegldiykkf
      241 ltrmtrisef lkvaeqvgid rgdipdlsqa psslldaleq hlaslegkki kdstaasrat
      301 tlsnavssla stglsltkvd erekqaalee eqarlkalke qrlkelakkp htslttaasp
      361 vstsaggimt apaidifstp sssnstsklp ndlldlqqpt fhpsvhpmst asqvastwgd
      421 pfsatvdavd daipslnpfl tkssgdvhls issdvstftt rtpthemfvg ftpspvaqph
      481 psaglnvdfe svfgnkstnv ivdsggfdel ggllkptvas qnqnlpvakl ppsklvsddl
      541 dsslanlvgn lgigngttkn dvnwsqpgek kltggsnwqp kvapttawna atmngmhfpq
      601 yappvmaypa ttptgmigyg ippqmgsvpv mtqptliysq pvmrppnpfg pvsgaqiqfm
//
LOCUS       XP_054226074             655 aa            linear   PRI 05-AUG-2025
DEFINITION  phosphatidylinositol-binding clathrin assembly protein isoform X3
            [Homo sapiens].
ACCESSION   XP_054226074
VERSION     XP_054226074.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370099.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..655
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..655
                     /product="phosphatidylinositol-binding clathrin assembly
                     protein isoform X3"
                     /calculated_mol_wt=71037
     Region          24..282
                     /region_name="ANTH"
                     /note="ANTH domain; pfam07651"
                     /db_xref="CDD:400137"
     Site            order(28,38,40..41)
                     /site_type="other"
                     /note="PtdIns(4,5)P2-binding site [chemical binding]"
                     /db_xref="CDD:340782"
     CDS             1..655
                     /gene="PICALM"
                     /gene_synonym="CALM; CLTH; LAP"
                     /coded_by="XM_054370099.1:305..2272"
                     /db_xref="GeneID:8301"
                     /db_xref="HGNC:HGNC:15514"
                     /db_xref="MIM:603025"
ORIGIN      
        1 msgqsltdri taaqhsvtgs avsktvckat theimgpkkk hldyliqctn emnvnipqla
       61 dslferttns swvvvfksli tthhlmvygn erfiqylasr ntlfnlsnfl dksglqgydm
      121 stfirrysry lnekavsyrq vafdftkvkr gadgvmrtmn tekllktvpi iqnqmdalld
      181 fnvnsneltn gvinaafmll fkdairlfaa ynegiinlle kyfdmkknqc kegldiykkf
      241 ltrmtrisef lkvaeqvgid rgdipdlsqa psslldaleq hlaslegkki kdstaasrat
      301 tlsnavssla stglsltkvd erekqaalee eqarlkalke qrlkelakkp htslttaasp
      361 vstsaggimt apaidifstp sssnstsklp ndlldlqqpt fhpsvhpmst asqvastwgd
      421 pfsatvdavd daipslnpfl tkssgdvhls issdvstftt rtpthemfvg ftpspvaqph
      481 psaglnvdfe svfgnkstnv ivdsgggllk ptvasqnqnl pvaklppskl vsddldssla
      541 nlvgnlgign gttkndvnws qpgekkltgg snwqpkvapt tawnaatmng mhfpqyappv
      601 maypattptg migygippqm gsvpvmtqpt liysqpvmrp pnpfgpvsga qiqfm
//
LOCUS       XP_054226075             653 aa            linear   PRI 05-AUG-2025
DEFINITION  phosphatidylinositol-binding clathrin assembly protein isoform X4
            [Homo sapiens].
ACCESSION   XP_054226075
VERSION     XP_054226075.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370100.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..653
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..653
                     /product="phosphatidylinositol-binding clathrin assembly
                     protein isoform X4"
                     /calculated_mol_wt=70881
     Region          24..282
                     /region_name="ANTH"
                     /note="ANTH domain; pfam07651"
                     /db_xref="CDD:400137"
     Site            order(28,38,40..41)
                     /site_type="other"
                     /note="PtdIns(4,5)P2-binding site [chemical binding]"
                     /db_xref="CDD:340782"
     CDS             1..653
                     /gene="PICALM"
                     /gene_synonym="CALM; CLTH; LAP"
                     /coded_by="XM_054370100.1:305..2266"
                     /db_xref="GeneID:8301"
                     /db_xref="HGNC:HGNC:15514"
                     /db_xref="MIM:603025"
ORIGIN      
        1 msgqsltdri taaqhsvtgs avsktvckat theimgpkkk hldyliqctn emnvnipqla
       61 dslferttns swvvvfksli tthhlmvygn erfiqylasr ntlfnlsnfl dksglqgydm
      121 stfirrysry lnekavsyrq vafdftkvkr gadgvmrtmn tekllktvpi iqnqmdalld
      181 fnvnsneltn gvinaafmll fkdairlfaa ynegiinlle kyfdmkknqc kegldiykkf
      241 ltrmtrisef lkvaeqvgid rgdipdlsqa psslldaleq hlaslegkki kdstaasrat
      301 tlsnavssla stglsltkvd erekqaalee eqarlkalke qrlkelakkp htslttaasp
      361 vstsaggimt apaidifstp sssnstsklp ndlldlqqpt fhpsvhpmst asqvastwgd
      421 avddaipsln pfltkssgdv hlsissdvst fttrtpthem fvgftpspva qphpsaglnv
      481 dfesvfgnks tnvivdsggf delggllkpt vasqnqnlpv aklppsklvs ddldsslanl
      541 vgnlgigngt tkndvnwsqp gekkltggsn wqpkvaptta wnaatmngmh fpqyappvma
      601 ypattptgmi gygippqmgs vpvmtqptli ysqpvmrppn pfgpvsgaqi qfm
//
LOCUS       XP_054226076             648 aa            linear   PRI 05-AUG-2025
DEFINITION  phosphatidylinositol-binding clathrin assembly protein isoform X5
            [Homo sapiens].
ACCESSION   XP_054226076
VERSION     XP_054226076.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370101.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..648
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..648
                     /product="phosphatidylinositol-binding clathrin assembly
                     protein isoform X5"
                     /calculated_mol_wt=70319
     Region          24..282
                     /region_name="ANTH"
                     /note="ANTH domain; pfam07651"
                     /db_xref="CDD:400137"
     Site            order(28,38,40..41)
                     /site_type="other"
                     /note="PtdIns(4,5)P2-binding site [chemical binding]"
                     /db_xref="CDD:340782"
     CDS             1..648
                     /gene="PICALM"
                     /gene_synonym="CALM; CLTH; LAP"
                     /coded_by="XM_054370101.1:305..2251"
                     /db_xref="GeneID:8301"
                     /db_xref="HGNC:HGNC:15514"
                     /db_xref="MIM:603025"
ORIGIN      
        1 msgqsltdri taaqhsvtgs avsktvckat theimgpkkk hldyliqctn emnvnipqla
       61 dslferttns swvvvfksli tthhlmvygn erfiqylasr ntlfnlsnfl dksglqgydm
      121 stfirrysry lnekavsyrq vafdftkvkr gadgvmrtmn tekllktvpi iqnqmdalld
      181 fnvnsneltn gvinaafmll fkdairlfaa ynegiinlle kyfdmkknqc kegldiykkf
      241 ltrmtrisef lkvaeqvgid rgdipdlsqa psslldaleq hlaslegkki kdstaasrat
      301 tlsnavssla stglsltkvd erekqaalee eqarlkalke qrlkelakkp htslttaasp
      361 vstsaggimt apaidifstp sssnstsklp ndlldlqqpt fhpsvhpmst asqvastwgd
      421 avddaipsln pfltkssgdv hlsissdvst fttrtpthem fvgftpspva qphpsaglnv
      481 dfesvfgnks tnvivdsggg llkptvasqn qnlpvaklpp sklvsddlds slanlvgnlg
      541 igngttkndv nwsqpgekkl tggsnwqpkv apttawnaat mngmhfpqya ppvmaypatt
      601 ptgmigygip pqmgsvpvmt qptliysqpv mrppnpfgpv sgaqiqfm
//
LOCUS       XP_054226077             647 aa            linear   PRI 05-AUG-2025
DEFINITION  phosphatidylinositol-binding clathrin assembly protein isoform X6
            [Homo sapiens].
ACCESSION   XP_054226077
VERSION     XP_054226077.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370102.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..647
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..647
                     /product="phosphatidylinositol-binding clathrin assembly
                     protein isoform X6"
                     /calculated_mol_wt=70062
     Region          24..282
                     /region_name="ANTH"
                     /note="ANTH domain; pfam07651"
                     /db_xref="CDD:400137"
     Site            order(28,38,40..41)
                     /site_type="other"
                     /note="PtdIns(4,5)P2-binding site [chemical binding]"
                     /db_xref="CDD:340782"
     CDS             1..647
                     /gene="PICALM"
                     /gene_synonym="CALM; CLTH; LAP"
                     /coded_by="XM_054370102.1:305..2248"
                     /db_xref="GeneID:8301"
                     /db_xref="HGNC:HGNC:15514"
                     /db_xref="MIM:603025"
ORIGIN      
        1 msgqsltdri taaqhsvtgs avsktvckat theimgpkkk hldyliqctn emnvnipqla
       61 dslferttns swvvvfksli tthhlmvygn erfiqylasr ntlfnlsnfl dksglqgydm
      121 stfirrysry lnekavsyrq vafdftkvkr gadgvmrtmn tekllktvpi iqnqmdalld
      181 fnvnsneltn gvinaafmll fkdairlfaa ynegiinlle kyfdmkknqc kegldiykkf
      241 ltrmtrisef lkvaeqvgid rgdipdlsqa psslldaleq hlaslegkki kdstaasrat
      301 tlsnavssla stglsltkvd erekqaalee eqarlkalke qrlkelakkp htslttaasp
      361 vstsaggimt apaidifstp sssnstsklp ndlldlqqpt fhpsvhpmst asqvastwgd
      421 pfsatvdavd daipslnpfl tkssgdvhls issdvstftt rtpthemfvg ftpspvaqph
      481 psaglnvdfe svfgnkstnv ivdsgggllk ptvasqnqnl pvaklppskl vsddldssla
      541 nlvgnlgign gttkndvnws qpgekkltgg snwqpkvapt tawnaatmap pvmaypattp
      601 tgmigygipp qmgsvpvmtq ptliysqpvm rppnpfgpvs gaqiqfm
//
LOCUS       XP_054226078             640 aa            linear   PRI 05-AUG-2025
DEFINITION  phosphatidylinositol-binding clathrin assembly protein isoform X7
            [Homo sapiens].
ACCESSION   XP_054226078
VERSION     XP_054226078.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370103.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..640
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..640
                     /product="phosphatidylinositol-binding clathrin assembly
                     protein isoform X7"
                     /calculated_mol_wt=69344
     Region          24..282
                     /region_name="ANTH"
                     /note="ANTH domain; pfam07651"
                     /db_xref="CDD:400137"
     Site            order(28,38,40..41)
                     /site_type="other"
                     /note="PtdIns(4,5)P2-binding site [chemical binding]"
                     /db_xref="CDD:340782"
     CDS             1..640
                     /gene="PICALM"
                     /gene_synonym="CALM; CLTH; LAP"
                     /coded_by="XM_054370103.1:305..2227"
                     /db_xref="GeneID:8301"
                     /db_xref="HGNC:HGNC:15514"
                     /db_xref="MIM:603025"
ORIGIN      
        1 msgqsltdri taaqhsvtgs avsktvckat theimgpkkk hldyliqctn emnvnipqla
       61 dslferttns swvvvfksli tthhlmvygn erfiqylasr ntlfnlsnfl dksglqgydm
      121 stfirrysry lnekavsyrq vafdftkvkr gadgvmrtmn tekllktvpi iqnqmdalld
      181 fnvnsneltn gvinaafmll fkdairlfaa ynegiinlle kyfdmkknqc kegldiykkf
      241 ltrmtrisef lkvaeqvgid rgdipdlsqa psslldaleq hlaslegkki kdstaasrat
      301 tlsnavssla stglsltkvd erekqaalee eqarlkalke qrlkelakkp htslttaasp
      361 vstsaggimt apaidifstp sssnstsklp ndlldlqqpt fhpsvhpmst asqvastwgd
      421 avddaipsln pfltkssgdv hlsissdvst fttrtpthem fvgftpspva qphpsaglnv
      481 dfesvfgnks tnvivdsggg llkptvasqn qnlpvaklpp sklvsddlds slanlvgnlg
      541 igngttkndv nwsqpgekkl tggsnwqpkv apttawnaat mappvmaypa ttptgmigyg
      601 ippqmgsvpv mtqptliysq pvmrppnpfg pvsgaqiqfm
//
LOCUS       XP_054226079             635 aa            linear   PRI 05-AUG-2025
DEFINITION  phosphatidylinositol-binding clathrin assembly protein isoform X8
            [Homo sapiens].
ACCESSION   XP_054226079
VERSION     XP_054226079.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370104.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..635
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..635
                     /product="phosphatidylinositol-binding clathrin assembly
                     protein isoform X8"
                     /calculated_mol_wt=68703
     Region          1..231
                     /region_name="ANTH"
                     /note="ANTH domain; pfam07651"
                     /db_xref="CDD:400137"
     CDS             1..635
                     /gene="PICALM"
                     /gene_synonym="CALM; CLTH; LAP"
                     /coded_by="XM_054370104.1:165..2072"
                     /db_xref="GeneID:8301"
                     /db_xref="HGNC:HGNC:15514"
                     /db_xref="MIM:603025"
ORIGIN      
        1 mnvnipqlad slferttnss wvvvfkslit thhlmvygne rfiqylasrn tlfnlsnfld
       61 ksglqgydms tfirrysryl nekavsyrqv afdftkvkrg adgvmrtmnt ekllktvpii
      121 qnqmdalldf nvnsneltng vinaafmllf kdairlfaay negiinllek yfdmkknqck
      181 egldiykkfl trmtrisefl kvaeqvgidr gdipdlsqap sslldaleqh laslegkkik
      241 dstaasratt lsnavsslas tglsltkvde rekqaaleee qarlkalkeq rlkelakkph
      301 tslttaaspv stsaggimta paidifstps ssnstsklpn dlldlqqptf hpsvhpmsta
      361 sqvastwgdp fsatvdavdd aipslnpflt kssgdvhlsi ssdvstfttr tpthemfvgf
      421 tpspvaqphp saglnvdfes vfgnkstnvi vdsggfdelg gllkptvasq nqnlpvaklp
      481 psklvsddld sslanlvgnl gigngttknd vnwsqpgekk ltggsnwqpk vapttawnaa
      541 tmngmhfpqy appvmaypat tptgmigygi ppqmgsvpvm tqptliysqp vmrppnpfgp
      601 vsgaqlsaas spsshsphra sgkdpfaels ledfl
//
LOCUS       XP_054226080             627 aa            linear   PRI 05-AUG-2025
DEFINITION  phosphatidylinositol-binding clathrin assembly protein isoform X9
            [Homo sapiens].
ACCESSION   XP_054226080
VERSION     XP_054226080.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370105.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..627
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..627
                     /product="phosphatidylinositol-binding clathrin assembly
                     protein isoform X9"
                     /calculated_mol_wt=68072
     Region          24..282
                     /region_name="ANTH"
                     /note="ANTH domain; pfam07651"
                     /db_xref="CDD:400137"
     Site            order(28,38,40..41)
                     /site_type="other"
                     /note="PtdIns(4,5)P2-binding site [chemical binding]"
                     /db_xref="CDD:340782"
     CDS             1..627
                     /gene="PICALM"
                     /gene_synonym="CALM; CLTH; LAP"
                     /coded_by="XM_054370105.1:305..2188"
                     /db_xref="GeneID:8301"
                     /db_xref="HGNC:HGNC:15514"
                     /db_xref="MIM:603025"
ORIGIN      
        1 msgqsltdri taaqhsvtgs avsktvckat theimgpkkk hldyliqctn emnvnipqla
       61 dslferttns swvvvfksli tthhlmvygn erfiqylasr ntlfnlsnfl dksglqgydm
      121 stfirrysry lnekavsyrq vafdftkvkr gadgvmrtmn tekllktvpi iqnqmdalld
      181 fnvnsneltn gvinaafmll fkdairlfaa ynegiinlle kyfdmkknqc kegldiykkf
      241 ltrmtrisef lkvaeqvgid rgdipdlsqa psslldaleq hlaslegkki kdstaasrat
      301 tlsnavssla stglsltkvd erekqaalee eqarlkalke qrlkelakkp htslttaasp
      361 vstsaggimt apaidifstp sssnstsklp ndlldlqqpt fhpsvhpmst asqvastwgd
      421 pfsatvdavd daipslnpfl tkssgdvhls issdvstftt rtpthemfvg ftpspvaqph
      481 psaglnvdfe svfgnkstnv ivdsgggllk ptvasqnqnl pvaklppskl vsddldssla
      541 nlvgnlgign gttkndvnws qpgekkltgg snwqpkvapt tawnaatmpp qmgsvpvmtq
      601 ptliysqpvm rppnpfgpvs gaqiqfm
//
LOCUS       XP_054226081             625 aa            linear   PRI 05-AUG-2025
DEFINITION  phosphatidylinositol-binding clathrin assembly protein isoform X10
            [Homo sapiens].
ACCESSION   XP_054226081
VERSION     XP_054226081.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370106.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..625
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..625
                     /product="phosphatidylinositol-binding clathrin assembly
                     protein isoform X10"
                     /calculated_mol_wt=67916
     Region          24..282
                     /region_name="ANTH"
                     /note="ANTH domain; pfam07651"
                     /db_xref="CDD:400137"
     Site            order(28,38,40..41)
                     /site_type="other"
                     /note="PtdIns(4,5)P2-binding site [chemical binding]"
                     /db_xref="CDD:340782"
     CDS             1..625
                     /gene="PICALM"
                     /gene_synonym="CALM; CLTH; LAP"
                     /coded_by="XM_054370106.1:305..2182"
                     /db_xref="GeneID:8301"
                     /db_xref="HGNC:HGNC:15514"
                     /db_xref="MIM:603025"
ORIGIN      
        1 msgqsltdri taaqhsvtgs avsktvckat theimgpkkk hldyliqctn emnvnipqla
       61 dslferttns swvvvfksli tthhlmvygn erfiqylasr ntlfnlsnfl dksglqgydm
      121 stfirrysry lnekavsyrq vafdftkvkr gadgvmrtmn tekllktvpi iqnqmdalld
      181 fnvnsneltn gvinaafmll fkdairlfaa ynegiinlle kyfdmkknqc kegldiykkf
      241 ltrmtrisef lkvaeqvgid rgdipdlsqa psslldaleq hlaslegkki kdstaasrat
      301 tlsnavssla stglsltkvd erekqaalee eqarlkalke qrlkelakkp htslttaasp
      361 vstsaggimt apaidifstp sssnstsklp ndlldlqqpt fhpsvhpmst asqvastwgd
      421 avddaipsln pfltkssgdv hlsissdvst fttrtpthem fvgftpspva qphpsaglnv
      481 dfesvfgnks tnvivdsggf delggllkpt vasqnqnlpv aklppsklvs ddldsslanl
      541 vgnlgigngt tkndvnwsqp gekkltggsn wqpkvaptta wnaatmppqm gsvpvmtqpt
      601 liysqpvmrp pnpfgpvsga qiqfm
//
LOCUS       XP_054226082             620 aa            linear   PRI 05-AUG-2025
DEFINITION  phosphatidylinositol-binding clathrin assembly protein isoform X11
            [Homo sapiens].
ACCESSION   XP_054226082
VERSION     XP_054226082.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370107.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..620
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..620
                     /product="phosphatidylinositol-binding clathrin assembly
                     protein isoform X11"
                     /calculated_mol_wt=67354
     Region          24..282
                     /region_name="ANTH"
                     /note="ANTH domain; pfam07651"
                     /db_xref="CDD:400137"
     Site            order(28,38,40..41)
                     /site_type="other"
                     /note="PtdIns(4,5)P2-binding site [chemical binding]"
                     /db_xref="CDD:340782"
     CDS             1..620
                     /gene="PICALM"
                     /gene_synonym="CALM; CLTH; LAP"
                     /coded_by="XM_054370107.1:305..2167"
                     /db_xref="GeneID:8301"
                     /db_xref="HGNC:HGNC:15514"
                     /db_xref="MIM:603025"
ORIGIN      
        1 msgqsltdri taaqhsvtgs avsktvckat theimgpkkk hldyliqctn emnvnipqla
       61 dslferttns swvvvfksli tthhlmvygn erfiqylasr ntlfnlsnfl dksglqgydm
      121 stfirrysry lnekavsyrq vafdftkvkr gadgvmrtmn tekllktvpi iqnqmdalld
      181 fnvnsneltn gvinaafmll fkdairlfaa ynegiinlle kyfdmkknqc kegldiykkf
      241 ltrmtrisef lkvaeqvgid rgdipdlsqa psslldaleq hlaslegkki kdstaasrat
      301 tlsnavssla stglsltkvd erekqaalee eqarlkalke qrlkelakkp htslttaasp
      361 vstsaggimt apaidifstp sssnstsklp ndlldlqqpt fhpsvhpmst asqvastwgd
      421 avddaipsln pfltkssgdv hlsissdvst fttrtpthem fvgftpspva qphpsaglnv
      481 dfesvfgnks tnvivdsggg llkptvasqn qnlpvaklpp sklvsddlds slanlvgnlg
      541 igngttkndv nwsqpgekkl tggsnwqpkv apttawnaat mppqmgsvpv mtqptliysq
      601 pvmrppnpfg pvsgaqiqfm
//
LOCUS       XP_054226083             605 aa            linear   PRI 05-AUG-2025
DEFINITION  phosphatidylinositol-binding clathrin assembly protein isoform X12
            [Homo sapiens].
ACCESSION   XP_054226083
VERSION     XP_054226083.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370108.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..605
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..605
                     /product="phosphatidylinositol-binding clathrin assembly
                     protein isoform X12"
                     /calculated_mol_wt=65700
     Region          24..282
                     /region_name="ANTH"
                     /note="ANTH domain; pfam07651"
                     /db_xref="CDD:400137"
     Site            order(28,38,40..41)
                     /site_type="other"
                     /note="PtdIns(4,5)P2-binding site [chemical binding]"
                     /db_xref="CDD:340782"
     CDS             1..605
                     /gene="PICALM"
                     /gene_synonym="CALM; CLTH; LAP"
                     /coded_by="XM_054370108.1:305..2122"
                     /db_xref="GeneID:8301"
                     /db_xref="HGNC:HGNC:15514"
                     /db_xref="MIM:603025"
ORIGIN      
        1 msgqsltdri taaqhsvtgs avsktvckat theimgpkkk hldyliqctn emnvnipqla
       61 dslferttns swvvvfksli tthhlmvygn erfiqylasr ntlfnlsnfl dksglqgydm
      121 stfirrysry lnekavsyrq vafdftkvkr gadgvmrtmn tekllktvpi iqnqmdalld
      181 fnvnsneltn gvinaafmll fkdairlfaa ynegiinlle kyfdmkknqc kegldiykkf
      241 ltrmtrisef lkvaeqvgid rgdipdlsqa psslldaleq hlaslegkki kdstaasrat
      301 tlsnavssla stglsltkvd erekqaalee eqarlkalke qrlkelakkp htslttaasp
      361 vstsaggimt apaidifstp sssnstsklp ndlldlqqpt fhpsvhpmst asqvastwgg
      421 ftpspvaqph psaglnvdfe svfgnkstnv ivdsgggllk ptvasqnqnl pvaklppskl
      481 vsddldssla nlvgnlgign gttkndvnws qpgekkltgg snwqpkvapt tawnaatmng
      541 mhfpqyappv maypattptg migygippqm gsvpvmtqpt liysqpvmrp pnpfgpvsga
      601 qiqfm
//
LOCUS       XP_054226084             602 aa            linear   PRI 05-AUG-2025
DEFINITION  phosphatidylinositol-binding clathrin assembly protein isoform X13
            [Homo sapiens].
ACCESSION   XP_054226084
VERSION     XP_054226084.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370109.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..602
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..602
                     /product="phosphatidylinositol-binding clathrin assembly
                     protein isoform X13"
                     /calculated_mol_wt=65287
     Region          24..282
                     /region_name="ANTH"
                     /note="ANTH domain; pfam07651"
                     /db_xref="CDD:400137"
     Site            order(28,38,40..41)
                     /site_type="other"
                     /note="PtdIns(4,5)P2-binding site [chemical binding]"
                     /db_xref="CDD:340782"
     CDS             1..602
                     /gene="PICALM"
                     /gene_synonym="CALM; CLTH; LAP"
                     /coded_by="XM_054370109.1:305..2113"
                     /db_xref="GeneID:8301"
                     /db_xref="HGNC:HGNC:15514"
                     /db_xref="MIM:603025"
ORIGIN      
        1 msgqsltdri taaqhsvtgs avsktvckat theimgpkkk hldyliqctn emnvnipqla
       61 dslferttns swvvvfksli tthhlmvygn erfiqylasr ntlfnlsnfl dksglqgydm
      121 stfirrysry lnekavsyrq vafdftkvkr gadgvmrtmn tekllktvpi iqnqmdalld
      181 fnvnsneltn gvinaafmll fkdairlfaa ynegiinlle kyfdmkknqc kegldiykkf
      241 ltrmtrisef lkvaeqvgid rgdipdlsqa psslldaleq hlaslegkki kdstaasrat
      301 tlsnavssla stglsltkvd erekqaalee eqarlkalke qrlkelakkp htslttaasp
      361 vstsaggimt apaidifstp sssnstsklp ndlldlqqpt fhpsvhpmst asqvastwgg
      421 ftpspvaqph psaglnvdfe svfgnkstnv ivdsggfdel ggllkptvas qnqnlpvakl
      481 ppsklvsddl dsslanlvgn lgigngttkn dvnwsqpgek kltggsnwqp kvapttawna
      541 atmappvmay pattptgmig ygippqmgsv pvmtqptliy sqpvmrppnp fgpvsgaqiq
      601 fm
//
LOCUS       XP_054226085             600 aa            linear   PRI 05-AUG-2025
DEFINITION  phosphatidylinositol-binding clathrin assembly protein isoform X27
            [Homo sapiens].
ACCESSION   XP_054226085
VERSION     XP_054226085.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370110.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 28% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..600
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..600
                     /product="phosphatidylinositol-binding clathrin assembly
                     protein isoform X27"
                     /calculated_mol_wt=65211
     Region          24..282
                     /region_name="ANTH"
                     /note="ANTH domain; pfam07651"
                     /db_xref="CDD:400137"
     Site            order(28,38,40..41)
                     /site_type="other"
                     /note="PtdIns(4,5)P2-binding site [chemical binding]"
                     /db_xref="CDD:340782"
     CDS             1..600
                     /gene="PICALM"
                     /gene_synonym="CALM; CLTH; LAP"
                     /coded_by="XM_054370110.1:305..2107"
                     /db_xref="GeneID:8301"
                     /db_xref="HGNC:HGNC:15514"
                     /db_xref="MIM:603025"
ORIGIN      
        1 msgqsltdri taaqhsvtgs avsktvckat theimgpkkk hldyliqctn emnvnipqla
       61 dslferttns swvvvfksli tthhlmvygn erfiqylasr ntlfnlsnfl dksglqgydm
      121 stfirrysry lnekavsyrq vafdftkvkr gadgvmrtmn tekllktvpi iqnqmdalld
      181 fnvnsneltn gvinaafmll fkdairlfaa ynegiinlle kyfdmkknqc kegldiykkf
      241 ltrmtrisef lkvaeqvgid rgdipdlsqa psslldaleq hlaslegkki kdstaasrat
      301 tlsnavssla stglsltkvd erekqaalee eqarlkalke qrlkelakkp htslttaasp
      361 vstsaggimt apaidifstp sssnstsklp ndlldlqqpt fhpsvhpmst asqvastwgg
      421 fdelggllkp tvasqnqnlp vaklppsklv sddldsslan lvgnlgigng ttkndvnwsq
      481 pgekkltggs nwqpkvaptt awnaatmngm hfpqyappvm aypattptgm igygippqmg
      541 svpvmtqptl iysqpvmrpp npfgpvsgaq lsaasspssh sphrasgkdp faelsledfl
//
LOCUS       XP_054226086             597 aa            linear   PRI 05-AUG-2025
DEFINITION  phosphatidylinositol-binding clathrin assembly protein isoform X14
            [Homo sapiens].
ACCESSION   XP_054226086
VERSION     XP_054226086.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370111.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..597
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..597
                     /product="phosphatidylinositol-binding clathrin assembly
                     protein isoform X14"
                     /calculated_mol_wt=64725
     Region          24..282
                     /region_name="ANTH"
                     /note="ANTH domain; pfam07651"
                     /db_xref="CDD:400137"
     Site            order(28,38,40..41)
                     /site_type="other"
                     /note="PtdIns(4,5)P2-binding site [chemical binding]"
                     /db_xref="CDD:340782"
     CDS             1..597
                     /gene="PICALM"
                     /gene_synonym="CALM; CLTH; LAP"
                     /coded_by="XM_054370111.1:305..2098"
                     /db_xref="GeneID:8301"
                     /db_xref="HGNC:HGNC:15514"
                     /db_xref="MIM:603025"
ORIGIN      
        1 msgqsltdri taaqhsvtgs avsktvckat theimgpkkk hldyliqctn emnvnipqla
       61 dslferttns swvvvfksli tthhlmvygn erfiqylasr ntlfnlsnfl dksglqgydm
      121 stfirrysry lnekavsyrq vafdftkvkr gadgvmrtmn tekllktvpi iqnqmdalld
      181 fnvnsneltn gvinaafmll fkdairlfaa ynegiinlle kyfdmkknqc kegldiykkf
      241 ltrmtrisef lkvaeqvgid rgdipdlsqa psslldaleq hlaslegkki kdstaasrat
      301 tlsnavssla stglsltkvd erekqaalee eqarlkalke qrlkelakkp htslttaasp
      361 vstsaggimt apaidifstp sssnstsklp ndlldlqqpt fhpsvhpmst asqvastwgg
      421 ftpspvaqph psaglnvdfe svfgnkstnv ivdsgggllk ptvasqnqnl pvaklppskl
      481 vsddldssla nlvgnlgign gttkndvnws qpgekkltgg snwqpkvapt tawnaatmap
      541 pvmaypattp tgmigygipp qmgsvpvmtq ptliysqpvm rppnpfgpvs gaqiqfm
//
LOCUS       XP_054226087             597 aa            linear   PRI 05-AUG-2025
DEFINITION  phosphatidylinositol-binding clathrin assembly protein isoform X15
            [Homo sapiens].
ACCESSION   XP_054226087
VERSION     XP_054226087.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370112.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..597
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..597
                     /product="phosphatidylinositol-binding clathrin assembly
                     protein isoform X15"
                     /calculated_mol_wt=64944
     Region          24..282
                     /region_name="ANTH"
                     /note="ANTH domain; pfam07651"
                     /db_xref="CDD:400137"
     Site            order(28,38,40..41)
                     /site_type="other"
                     /note="PtdIns(4,5)P2-binding site [chemical binding]"
                     /db_xref="CDD:340782"
     CDS             1..597
                     /gene="PICALM"
                     /gene_synonym="CALM; CLTH; LAP"
                     /coded_by="XM_054370112.1:305..2098"
                     /db_xref="GeneID:8301"
                     /db_xref="HGNC:HGNC:15514"
                     /db_xref="MIM:603025"
ORIGIN      
        1 msgqsltdri taaqhsvtgs avsktvckat theimgpkkk hldyliqctn emnvnipqla
       61 dslferttns swvvvfksli tthhlmvygn erfiqylasr ntlfnlsnfl dksglqgydm
      121 stfirrysry lnekavsyrq vafdftkvkr gadgvmrtmn tekllktvpi iqnqmdalld
      181 fnvnsneltn gvinaafmll fkdairlfaa ynegiinlle kyfdmkknqc kegldiykkf
      241 ltrmtrisef lkvaeqvgid rgdipdlsqa psslldaleq hlaslegkki kdstaasrat
      301 tlsnavssla stglsltkvd erekqaalee eqarlkalke qrlkelakkp htslttaasp
      361 vstsaggimt apaidifstp sssnstsklp ndlldlqqpt fhpsvhpmst asqvastwgd
      421 pfsatvdavd daipslnpfl tkssgdvhls issdvstftt rtpthemfvg ftpspvaqph
      481 psaglnvdfe svfgnkstnv ivdsggfdel ggllkptvas qnqnlpvakl ppsklvsddl
      541 dsslanlvgn lgigngttkn dvnwsqpgek kltggsnwqp kvapttawna atmiqfm
//
LOCUS       XP_054226088             592 aa            linear   PRI 05-AUG-2025
DEFINITION  phosphatidylinositol-binding clathrin assembly protein isoform X16
            [Homo sapiens].
ACCESSION   XP_054226088
VERSION     XP_054226088.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370113.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..592
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..592
                     /product="phosphatidylinositol-binding clathrin assembly
                     protein isoform X16"
                     /calculated_mol_wt=64382
     Region          24..282
                     /region_name="ANTH"
                     /note="ANTH domain; pfam07651"
                     /db_xref="CDD:400137"
     Site            order(28,38,40..41)
                     /site_type="other"
                     /note="PtdIns(4,5)P2-binding site [chemical binding]"
                     /db_xref="CDD:340782"
     CDS             1..592
                     /gene="PICALM"
                     /gene_synonym="CALM; CLTH; LAP"
                     /coded_by="XM_054370113.1:305..2083"
                     /db_xref="GeneID:8301"
                     /db_xref="HGNC:HGNC:15514"
                     /db_xref="MIM:603025"
ORIGIN      
        1 msgqsltdri taaqhsvtgs avsktvckat theimgpkkk hldyliqctn emnvnipqla
       61 dslferttns swvvvfksli tthhlmvygn erfiqylasr ntlfnlsnfl dksglqgydm
      121 stfirrysry lnekavsyrq vafdftkvkr gadgvmrtmn tekllktvpi iqnqmdalld
      181 fnvnsneltn gvinaafmll fkdairlfaa ynegiinlle kyfdmkknqc kegldiykkf
      241 ltrmtrisef lkvaeqvgid rgdipdlsqa psslldaleq hlaslegkki kdstaasrat
      301 tlsnavssla stglsltkvd erekqaalee eqarlkalke qrlkelakkp htslttaasp
      361 vstsaggimt apaidifstp sssnstsklp ndlldlqqpt fhpsvhpmst asqvastwgd
      421 pfsatvdavd daipslnpfl tkssgdvhls issdvstftt rtpthemfvg ftpspvaqph
      481 psaglnvdfe svfgnkstnv ivdsgggllk ptvasqnqnl pvaklppskl vsddldssla
      541 nlvgnlgign gttkndvnws qpgekkltgg snwqpkvapt tawnaatmiq fm
//
LOCUS       XP_054226089             590 aa            linear   PRI 05-AUG-2025
DEFINITION  phosphatidylinositol-binding clathrin assembly protein isoform X17
            [Homo sapiens].
ACCESSION   XP_054226089
VERSION     XP_054226089.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370114.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..590
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..590
                     /product="phosphatidylinositol-binding clathrin assembly
                     protein isoform X17"
                     /calculated_mol_wt=64226
     Region          24..282
                     /region_name="ANTH"
                     /note="ANTH domain; pfam07651"
                     /db_xref="CDD:400137"
     Site            order(28,38,40..41)
                     /site_type="other"
                     /note="PtdIns(4,5)P2-binding site [chemical binding]"
                     /db_xref="CDD:340782"
     CDS             1..590
                     /gene="PICALM"
                     /gene_synonym="CALM; CLTH; LAP"
                     /coded_by="XM_054370114.1:305..2077"
                     /db_xref="GeneID:8301"
                     /db_xref="HGNC:HGNC:15514"
                     /db_xref="MIM:603025"
ORIGIN      
        1 msgqsltdri taaqhsvtgs avsktvckat theimgpkkk hldyliqctn emnvnipqla
       61 dslferttns swvvvfksli tthhlmvygn erfiqylasr ntlfnlsnfl dksglqgydm
      121 stfirrysry lnekavsyrq vafdftkvkr gadgvmrtmn tekllktvpi iqnqmdalld
      181 fnvnsneltn gvinaafmll fkdairlfaa ynegiinlle kyfdmkknqc kegldiykkf
      241 ltrmtrisef lkvaeqvgid rgdipdlsqa psslldaleq hlaslegkki kdstaasrat
      301 tlsnavssla stglsltkvd erekqaalee eqarlkalke qrlkelakkp htslttaasp
      361 vstsaggimt apaidifstp sssnstsklp ndlldlqqpt fhpsvhpmst asqvastwgd
      421 avddaipsln pfltkssgdv hlsissdvst fttrtpthem fvgftpspva qphpsaglnv
      481 dfesvfgnks tnvivdsggf delggllkpt vasqnqnlpv aklppsklvs ddldsslanl
      541 vgnlgigngt tkndvnwsqp gekkltggsn wqpkvaptta wnaatmiqfm
//
LOCUS       XP_054226090             582 aa            linear   PRI 05-AUG-2025
DEFINITION  phosphatidylinositol-binding clathrin assembly protein isoform X18
            [Homo sapiens].
ACCESSION   XP_054226090
VERSION     XP_054226090.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370115.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..582
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..582
                     /product="phosphatidylinositol-binding clathrin assembly
                     protein isoform X18"
                     /calculated_mol_wt=63296
     Region          24..282
                     /region_name="ANTH"
                     /note="ANTH domain; pfam07651"
                     /db_xref="CDD:400137"
     Site            order(28,38,40..41)
                     /site_type="other"
                     /note="PtdIns(4,5)P2-binding site [chemical binding]"
                     /db_xref="CDD:340782"
     CDS             1..582
                     /gene="PICALM"
                     /gene_synonym="CALM; CLTH; LAP"
                     /coded_by="XM_054370115.1:305..2053"
                     /db_xref="GeneID:8301"
                     /db_xref="HGNC:HGNC:15514"
                     /db_xref="MIM:603025"
ORIGIN      
        1 msgqsltdri taaqhsvtgs avsktvckat theimgpkkk hldyliqctn emnvnipqla
       61 dslferttns swvvvfksli tthhlmvygn erfiqylasr ntlfnlsnfl dksglqgydm
      121 stfirrysry lnekavsyrq vafdftkvkr gadgvmrtmn tekllktvpi iqnqmdalld
      181 fnvnsneltn gvinaafmll fkdairlfaa ynegiinlle kyfdmkknqc kegldiykkf
      241 ltrmtrisef lkvaeqvgid rgdipdlsqa psslldaleq hlaslegkki kdstaasrat
      301 tlsnavssla stglsltkvd erekqaalee eqarlkalke qrlkelakkp htslttaasp
      361 vstsaggimt apaidifstp sssnstsklp ndlldlqqpt fhpsvhpmst asqvastwgg
      421 ftpspvaqph psaglnvdfe svfgnkstnv ivdsggfdel ggllkptvas qnqnlpvakl
      481 ppsklvsddl dsslanlvgn lgigngttkn dvnwsqpgek kltggsnwqp kvapttawna
      541 atmppqmgsv pvmtqptliy sqpvmrppnp fgpvsgaqiq fm
//
LOCUS       XP_054226091             577 aa            linear   PRI 05-AUG-2025
DEFINITION  phosphatidylinositol-binding clathrin assembly protein isoform X19
            [Homo sapiens].
ACCESSION   XP_054226091
VERSION     XP_054226091.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370116.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..577
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..577
                     /product="phosphatidylinositol-binding clathrin assembly
                     protein isoform X19"
                     /calculated_mol_wt=62735
     Region          24..282
                     /region_name="ANTH"
                     /note="ANTH domain; pfam07651"
                     /db_xref="CDD:400137"
     Site            order(28,38,40..41)
                     /site_type="other"
                     /note="PtdIns(4,5)P2-binding site [chemical binding]"
                     /db_xref="CDD:340782"
     CDS             1..577
                     /gene="PICALM"
                     /gene_synonym="CALM; CLTH; LAP"
                     /coded_by="XM_054370116.1:305..2038"
                     /db_xref="GeneID:8301"
                     /db_xref="HGNC:HGNC:15514"
                     /db_xref="MIM:603025"
ORIGIN      
        1 msgqsltdri taaqhsvtgs avsktvckat theimgpkkk hldyliqctn emnvnipqla
       61 dslferttns swvvvfksli tthhlmvygn erfiqylasr ntlfnlsnfl dksglqgydm
      121 stfirrysry lnekavsyrq vafdftkvkr gadgvmrtmn tekllktvpi iqnqmdalld
      181 fnvnsneltn gvinaafmll fkdairlfaa ynegiinlle kyfdmkknqc kegldiykkf
      241 ltrmtrisef lkvaeqvgid rgdipdlsqa psslldaleq hlaslegkki kdstaasrat
      301 tlsnavssla stglsltkvd erekqaalee eqarlkalke qrlkelakkp htslttaasp
      361 vstsaggimt apaidifstp sssnstsklp ndlldlqqpt fhpsvhpmst asqvastwgg
      421 ftpspvaqph psaglnvdfe svfgnkstnv ivdsgggllk ptvasqnqnl pvaklppskl
      481 vsddldssla nlvgnlgign gttkndvnws qpgekkltgg snwqpkvapt tawnaatmpp
      541 qmgsvpvmtq ptliysqpvm rppnpfgpvs gaqiqfm
//
LOCUS       XP_054226092             574 aa            linear   PRI 05-AUG-2025
DEFINITION  phosphatidylinositol-binding clathrin assembly protein isoform X20
            [Homo sapiens].
ACCESSION   XP_054226092
VERSION     XP_054226092.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370117.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..574
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..574
                     /product="phosphatidylinositol-binding clathrin assembly
                     protein isoform X20"
                     /calculated_mol_wt=62607
     Region          24..282
                     /region_name="ANTH"
                     /note="ANTH domain; pfam07651"
                     /db_xref="CDD:400137"
     Site            order(28,38,40..41)
                     /site_type="other"
                     /note="PtdIns(4,5)P2-binding site [chemical binding]"
                     /db_xref="CDD:340782"
     CDS             1..574
                     /gene="PICALM"
                     /gene_synonym="CALM; CLTH; LAP"
                     /coded_by="XM_054370117.1:305..2029"
                     /db_xref="GeneID:8301"
                     /db_xref="HGNC:HGNC:15514"
                     /db_xref="MIM:603025"
ORIGIN      
        1 msgqsltdri taaqhsvtgs avsktvckat theimgpkkk hldyliqctn emnvnipqla
       61 dslferttns swvvvfksli tthhlmvygn erfiqylasr ntlfnlsnfl dksglqgydm
      121 stfirrysry lnekavsyrq vafdftkvkr gadgvmrtmn tekllktvpi iqnqmdalld
      181 fnvnsneltn gvinaafmll fkdairlfaa ynegiinlle kyfdmkknqc kegldiykkf
      241 ltrmtrisef lkvaeqvgid rgdipdlsqa psslldaleq hlaslegkki kdstaasrat
      301 tlsnavssla stglsltkvd erekqaalee eqarlkalke qrlkelakkp htslttaasp
      361 vstsaggimt apaidifstp sssnstsklp ndlldlqqpt fhpsvhpmst asqvastwgg
      421 fdelggllkp tvasqnqnlp vaklppsklv sddldsslan lvgnlgigng ttkndvnwsq
      481 pgekkltggs nwqpkvaptt awnaatmngm hfpqyappvm aypattptgm igygippqmg
      541 svpvmtqptl iysqpvmrpp npfgpvsgaq iqfm
//
LOCUS       XP_054226093             566 aa            linear   PRI 05-AUG-2025
DEFINITION  phosphatidylinositol-binding clathrin assembly protein isoform X21
            [Homo sapiens].
ACCESSION   XP_054226093
VERSION     XP_054226093.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370118.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..566
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..566
                     /product="phosphatidylinositol-binding clathrin assembly
                     protein isoform X21"
                     /calculated_mol_wt=61632
     Region          24..282
                     /region_name="ANTH"
                     /note="ANTH domain; pfam07651"
                     /db_xref="CDD:400137"
     Site            order(28,38,40..41)
                     /site_type="other"
                     /note="PtdIns(4,5)P2-binding site [chemical binding]"
                     /db_xref="CDD:340782"
     CDS             1..566
                     /gene="PICALM"
                     /gene_synonym="CALM; CLTH; LAP"
                     /coded_by="XM_054370118.1:305..2005"
                     /db_xref="GeneID:8301"
                     /db_xref="HGNC:HGNC:15514"
                     /db_xref="MIM:603025"
ORIGIN      
        1 msgqsltdri taaqhsvtgs avsktvckat theimgpkkk hldyliqctn emnvnipqla
       61 dslferttns swvvvfksli tthhlmvygn erfiqylasr ntlfnlsnfl dksglqgydm
      121 stfirrysry lnekavsyrq vafdftkvkr gadgvmrtmn tekllktvpi iqnqmdalld
      181 fnvnsneltn gvinaafmll fkdairlfaa ynegiinlle kyfdmkknqc kegldiykkf
      241 ltrmtrisef lkvaeqvgid rgdipdlsqa psslldaleq hlaslegkki kdstaasrat
      301 tlsnavssla stglsltkvd erekqaalee eqarlkalke qrlkelakkp htslttaasp
      361 vstsaggimt apaidifstp sssnstsklp ndlldlqqpt fhpsvhpmst asqvastwgg
      421 fdelggllkp tvasqnqnlp vaklppsklv sddldsslan lvgnlgigng ttkndvnwsq
      481 pgekkltggs nwqpkvaptt awnaatmapp vmaypattpt gmigygippq mgsvpvmtqp
      541 tliysqpvmr ppnpfgpvsg aqiqfm
//
LOCUS       XP_054226094             547 aa            linear   PRI 05-AUG-2025
DEFINITION  phosphatidylinositol-binding clathrin assembly protein isoform X22
            [Homo sapiens].
ACCESSION   XP_054226094
VERSION     XP_054226094.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370119.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..547
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..547
                     /product="phosphatidylinositol-binding clathrin assembly
                     protein isoform X22"
                     /calculated_mol_wt=59607
     Region          24..282
                     /region_name="ANTH"
                     /note="ANTH domain; pfam07651"
                     /db_xref="CDD:400137"
     Site            order(28,38,40..41)
                     /site_type="other"
                     /note="PtdIns(4,5)P2-binding site [chemical binding]"
                     /db_xref="CDD:340782"
     CDS             1..547
                     /gene="PICALM"
                     /gene_synonym="CALM; CLTH; LAP"
                     /coded_by="XM_054370119.1:305..1948"
                     /db_xref="GeneID:8301"
                     /db_xref="HGNC:HGNC:15514"
                     /db_xref="MIM:603025"
ORIGIN      
        1 msgqsltdri taaqhsvtgs avsktvckat theimgpkkk hldyliqctn emnvnipqla
       61 dslferttns swvvvfksli tthhlmvygn erfiqylasr ntlfnlsnfl dksglqgydm
      121 stfirrysry lnekavsyrq vafdftkvkr gadgvmrtmn tekllktvpi iqnqmdalld
      181 fnvnsneltn gvinaafmll fkdairlfaa ynegiinlle kyfdmkknqc kegldiykkf
      241 ltrmtrisef lkvaeqvgid rgdipdlsqa psslldaleq hlaslegkki kdstaasrat
      301 tlsnavssla stglsltkvd erekqaalee eqarlkalke qrlkelakkp htslttaasp
      361 vstsaggimt apaidifstp sssnstsklp ndlldlqqpt fhpsvhpmst asqvastwgg
      421 ftpspvaqph psaglnvdfe svfgnkstnv ivdsggfdel ggllkptvas qnqnlpvakl
      481 ppsklvsddl dsslanlvgn lgigngttkn dvnwsqpgek kltggsnwqp kvapttawna
      541 atmiqfm
//
LOCUS       XP_054226095             546 aa            linear   PRI 05-AUG-2025
DEFINITION  phosphatidylinositol-binding clathrin assembly protein isoform X23
            [Homo sapiens].
ACCESSION   XP_054226095
VERSION     XP_054226095.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370120.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..546
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..546
                     /product="phosphatidylinositol-binding clathrin assembly
                     protein isoform X23"
                     /calculated_mol_wt=59226
     Region          1..231
                     /region_name="ANTH"
                     /note="ANTH domain; pfam07651"
                     /db_xref="CDD:400137"
     CDS             1..546
                     /gene="PICALM"
                     /gene_synonym="CALM; CLTH; LAP"
                     /coded_by="XM_054370120.1:165..1805"
                     /db_xref="GeneID:8301"
                     /db_xref="HGNC:HGNC:15514"
                     /db_xref="MIM:603025"
ORIGIN      
        1 mnvnipqlad slferttnss wvvvfkslit thhlmvygne rfiqylasrn tlfnlsnfld
       61 ksglqgydms tfirrysryl nekavsyrqv afdftkvkrg adgvmrtmnt ekllktvpii
      121 qnqmdalldf nvnsneltng vinaafmllf kdairlfaay negiinllek yfdmkknqck
      181 egldiykkfl trmtrisefl kvaeqvgidr gdipdlsqap sslldaleqh laslegkkik
      241 dstaasratt lsnavsslas tglsltkvde rekqaaleee qarlkalkeq rlkelakkph
      301 tslttaaspv stsaggimta paidifstps ssnstsklpn dlldlqqptf hpsvhpmsta
      361 sqvastwggf tpspvaqphp saglnvdfes vfgnkstnvi vdsgggllkp tvasqnqnlp
      421 vaklppsklv sddldsslan lvgnlgigng ttkndvnwsq pgekkltggs nwqpkvaptt
      481 awnaatmapp vmaypattpt gmigygippq mgsvpvmtqp tliysqpvmr ppnpfgpvsg
      541 aqiqfm
//
LOCUS       XP_054226096             546 aa            linear   PRI 05-AUG-2025
DEFINITION  phosphatidylinositol-binding clathrin assembly protein isoform X24
            [Homo sapiens].
ACCESSION   XP_054226096
VERSION     XP_054226096.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370121.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..546
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..546
                     /product="phosphatidylinositol-binding clathrin assembly
                     protein isoform X24"
                     /calculated_mol_wt=59641
     Region          24..282
                     /region_name="ANTH"
                     /note="ANTH domain; pfam07651"
                     /db_xref="CDD:400137"
     Site            order(28,38,40..41)
                     /site_type="other"
                     /note="PtdIns(4,5)P2-binding site [chemical binding]"
                     /db_xref="CDD:340782"
     CDS             1..546
                     /gene="PICALM"
                     /gene_synonym="CALM; CLTH; LAP"
                     /coded_by="XM_054370121.1:305..1945"
                     /db_xref="GeneID:8301"
                     /db_xref="HGNC:HGNC:15514"
                     /db_xref="MIM:603025"
ORIGIN      
        1 msgqsltdri taaqhsvtgs avsktvckat theimgpkkk hldyliqctn emnvnipqla
       61 dslferttns swvvvfksli tthhlmvygn erfiqylasr ntlfnlsnfl dksglqgydm
      121 stfirrysry lnekavsyrq vafdftkvkr gadgvmrtmn tekllktvpi iqnqmdalld
      181 fnvnsneltn gvinaafmll fkdairlfaa ynegiinlle kyfdmkknqc kegldiykkf
      241 ltrmtrisef lkvaeqvgid rgdipdlsqa psslldaleq hlaslegkki kdstaasrat
      301 tlsnavssla stglsltkvd erekqaalee eqarlkalke qrlkelakkp htslttaasp
      361 vstsaggimt apaidifstp sssnstsklp ndlldlqqpt fhpsvhpmst asqvastwgg
      421 fdelggllkp tvasqnqnlp vaklppsklv sddldsslan lvgnlgigng ttkndvnwsq
      481 pgekkltggs nwqpkvaptt awnaatmppq mgsvpvmtqp tliysqpvmr ppnpfgpvsg
      541 aqiqfm
//
LOCUS       XP_054226097             542 aa            linear   PRI 05-AUG-2025
DEFINITION  phosphatidylinositol-binding clathrin assembly protein isoform X25
            [Homo sapiens].
ACCESSION   XP_054226097
VERSION     XP_054226097.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370122.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..542
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..542
                     /product="phosphatidylinositol-binding clathrin assembly
                     protein isoform X25"
                     /calculated_mol_wt=59045
     Region          24..282
                     /region_name="ANTH"
                     /note="ANTH domain; pfam07651"
                     /db_xref="CDD:400137"
     Site            order(28,38,40..41)
                     /site_type="other"
                     /note="PtdIns(4,5)P2-binding site [chemical binding]"
                     /db_xref="CDD:340782"
     CDS             1..542
                     /gene="PICALM"
                     /gene_synonym="CALM; CLTH; LAP"
                     /coded_by="XM_054370122.1:305..1933"
                     /db_xref="GeneID:8301"
                     /db_xref="HGNC:HGNC:15514"
                     /db_xref="MIM:603025"
ORIGIN      
        1 msgqsltdri taaqhsvtgs avsktvckat theimgpkkk hldyliqctn emnvnipqla
       61 dslferttns swvvvfksli tthhlmvygn erfiqylasr ntlfnlsnfl dksglqgydm
      121 stfirrysry lnekavsyrq vafdftkvkr gadgvmrtmn tekllktvpi iqnqmdalld
      181 fnvnsneltn gvinaafmll fkdairlfaa ynegiinlle kyfdmkknqc kegldiykkf
      241 ltrmtrisef lkvaeqvgid rgdipdlsqa psslldaleq hlaslegkki kdstaasrat
      301 tlsnavssla stglsltkvd erekqaalee eqarlkalke qrlkelakkp htslttaasp
      361 vstsaggimt apaidifstp sssnstsklp ndlldlqqpt fhpsvhpmst asqvastwgg
      421 ftpspvaqph psaglnvdfe svfgnkstnv ivdsgggllk ptvasqnqnl pvaklppskl
      481 vsddldssla nlvgnlgign gttkndvnws qpgekkltgg snwqpkvapt tawnaatmiq
      541 fm
//
LOCUS       XP_054226098             511 aa            linear   PRI 05-AUG-2025
DEFINITION  phosphatidylinositol-binding clathrin assembly protein isoform X26
            [Homo sapiens].
ACCESSION   XP_054226098
VERSION     XP_054226098.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370123.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..511
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..511
                     /product="phosphatidylinositol-binding clathrin assembly
                     protein isoform X26"
                     /calculated_mol_wt=55952
     Region          24..282
                     /region_name="ANTH"
                     /note="ANTH domain; pfam07651"
                     /db_xref="CDD:400137"
     Site            order(28,38,40..41)
                     /site_type="other"
                     /note="PtdIns(4,5)P2-binding site [chemical binding]"
                     /db_xref="CDD:340782"
     CDS             1..511
                     /gene="PICALM"
                     /gene_synonym="CALM; CLTH; LAP"
                     /coded_by="XM_054370123.1:305..1840"
                     /db_xref="GeneID:8301"
                     /db_xref="HGNC:HGNC:15514"
                     /db_xref="MIM:603025"
ORIGIN      
        1 msgqsltdri taaqhsvtgs avsktvckat theimgpkkk hldyliqctn emnvnipqla
       61 dslferttns swvvvfksli tthhlmvygn erfiqylasr ntlfnlsnfl dksglqgydm
      121 stfirrysry lnekavsyrq vafdftkvkr gadgvmrtmn tekllktvpi iqnqmdalld
      181 fnvnsneltn gvinaafmll fkdairlfaa ynegiinlle kyfdmkknqc kegldiykkf
      241 ltrmtrisef lkvaeqvgid rgdipdlsqa psslldaleq hlaslegkki kdstaasrat
      301 tlsnavssla stglsltkvd erekqaalee eqarlkalke qrlkelakkp htslttaasp
      361 vstsaggimt apaidifstp sssnstsklp ndlldlqqpt fhpsvhpmst asqvastwgg
      421 fdelggllkp tvasqnqnlp vaklppsklv sddldsslan lvgnlgigng ttkndvnwsq
      481 pgekkltggs nwqpkvaptt awnaatmiqf m
//
LOCUS       XP_054226099             769 aa            linear   PRI 05-AUG-2025
DEFINITION  cysteine--tRNA ligase, cytoplasmic isoform X1 [Homo sapiens].
ACCESSION   XP_054226099
VERSION     XP_054226099.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370124.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..769
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..769
                     /product="cysteine--tRNA ligase, cytoplasmic isoform X1"
                     /calculated_mol_wt=87278
     Region          3..76
                     /region_name="GST_C_CysRS_N"
                     /note="Glutathione S-transferase C-terminal-like, alpha
                     helical domain of Cysteinyl-tRNA synthetase from higher
                     eukaryotes; cd10310"
                     /db_xref="CDD:198343"
     Site            order(5..7,9..14,16..17,24,27,33..34)
                     /site_type="other"
                     /note="putative protein interface 1 [polypeptide binding]"
                     /db_xref="CDD:198343"
     Site            order(32..36,64..65,67..68,72,75..76)
                     /site_type="other"
                     /note="putative protein interface 2 [polypeptide binding]"
                     /db_xref="CDD:198343"
     Region          91..731
                     /region_name="PTZ00399"
                     /note="cysteinyl-tRNA-synthetase; Provisional"
                     /db_xref="CDD:240402"
     CDS             1..769
                     /gene="CARS1"
                     /gene_synonym="CARS; CYSRS; MCDDBH; MDBH; MGC:11246"
                     /coded_by="XM_054370124.1:57..2366"
                     /db_xref="GeneID:833"
                     /db_xref="HGNC:HGNC:1493"
                     /db_xref="MIM:123859"
ORIGIN      
        1 madssgqqap dyrsilsisd eaaraqalne hlstrsyvqg yslsqadvda frqlsappad
       61 pqlfhvarwf rhieallgsp cgkgqpcrlq askgrrvqpq wsppagtqpc rlhlynsltr
      121 nkevfipqdg kkvtwyccgp tvydashmgh arsyisfdil rrvlkdyfkf dvfycmnitd
      181 iddkiikrar qnhlfeqyre krpeaaqlle dvqaalkpfs vklnettdpd kkqmleriqh
      241 avqlateple kavqsrltge evnscvevll eeakdllsdw ldstlgcdvt dnsifsklpk
      301 fwegdfhrdm ealnvlppdv ltrvseyvpe ivnfvqkivd ngygyvsngs vyfdtakfas
      361 sekhsygklv peavgdqkal qegegdlsis adrlsekrsp ndfalwkask pgepswpcpw
      421 gkgrpgwhie csamagtllg asmdihgggf dlrfphhdne laqseayfen dcwvryflht
      481 ghltiagckm skslknfiti kdalkkhsar qlrlaflmhs wkdtldyssn tmesalqyek
      541 flnefflnvk dilrapvdit gqfekwgeee aelnknfydk ktaihkalcd nvdtrtvmee
      601 mralvsqcnl ymaarkavrk rpnqalleni alylthmlki fgaveedssl gfpvggpgts
      661 lsleatvmpy lqvlsefreg vrkiareqkv peilqlsdal rdnilpelgv rfedheglpt
      721 vvklvdrntl lkereekrrv eeekrkkkee aarrkqeqeh sesegleas
//
LOCUS       XP_054226101             551 aa            linear   PRI 05-AUG-2025
DEFINITION  cysteine--tRNA ligase, cytoplasmic isoform X3 [Homo sapiens].
ACCESSION   XP_054226101
VERSION     XP_054226101.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370126.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..551
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..551
                     /product="cysteine--tRNA ligase, cytoplasmic isoform X3"
                     /calculated_mol_wt=61983
     Region          3..76
                     /region_name="GST_C_CysRS_N"
                     /note="Glutathione S-transferase C-terminal-like, alpha
                     helical domain of Cysteinyl-tRNA synthetase from higher
                     eukaryotes; cd10310"
                     /db_xref="CDD:198343"
     Site            order(5..7,9..14,16..17,24,27,33..34)
                     /site_type="other"
                     /note="putative protein interface 1 [polypeptide binding]"
                     /db_xref="CDD:198343"
     Site            order(32..36,64..65,67..68,72,75..76)
                     /site_type="other"
                     /note="putative protein interface 2 [polypeptide binding]"
                     /db_xref="CDD:198343"
     Region          91..>510
                     /region_name="PTZ00399"
                     /note="cysteinyl-tRNA-synthetase; Provisional"
                     /db_xref="CDD:240402"
     CDS             1..551
                     /gene="CARS1"
                     /gene_synonym="CARS; CYSRS; MCDDBH; MDBH; MGC:11246"
                     /coded_by="XM_054370126.1:57..1712"
                     /db_xref="GeneID:833"
                     /db_xref="HGNC:HGNC:1493"
                     /db_xref="MIM:123859"
ORIGIN      
        1 madssgqqap dyrsilsisd eaaraqalne hlstrsyvqg yslsqadvda frqlsappad
       61 pqlfhvarwf rhieallgsp cgkgqpcrlq askgrrvqpq wsppagtqpc rlhlynsltr
      121 nkevfipqdg kkvtwyccgp tvydashmgh arsyisfdil rrvlkdyfkf dvfycmnitd
      181 iddkiikrar qnhlfeqyre krpeaaqlle dvqaalkpfs vklnettdpd kkqmleriqh
      241 avqlateple kavqsrltge evnscvevll eeakdllsdw ldstlgcdvt dnsifsklpk
      301 fwegdfhrdm ealnvlppdv ltrvseyvpe ivnfvqkivd ngygyvsngs vyfdtakfas
      361 sekhsygklv peavgdqkal qegegdlsis adrlsekrsp ndfalwkask pgepswpcpw
      421 gkgrpgwhie csamagtllg asmdihgggf dlrfphhdne laqseayfen dcwvryflht
      481 ghltiagckm skslknfiti kdalkkhsgr wlscvppqhg scgwpssctr grtpwttpat
      541 pwsqrfnmrs s
//
LOCUS       XP_054226102             448 aa            linear   PRI 05-AUG-2025
DEFINITION  caspase-1 isoform X1 [Homo sapiens].
ACCESSION   XP_054226102
VERSION     XP_054226102.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370127.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..448
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..448
                     /product="caspase-1 isoform X1"
                     /calculated_mol_wt=50249
     Region          <77..131
                     /region_name="DD"
                     /note="Death Domain Superfamily of protein-protein
                     interaction domains; cl14633"
                     /db_xref="CDD:472698"
     Region          197..446
                     /region_name="CASc"
                     /note="Caspase, interleukin-1 beta converting enzyme (ICE)
                     homologues; smart00115"
                     /db_xref="CDD:214521"
     Site            order(223,282,327,334,382..387,391..392)
                     /site_type="other"
                     /note="substrate pocket [chemical binding]"
                     /db_xref="CDD:237997"
     Site            order(281,329)
                     /site_type="active"
                     /db_xref="CDD:237997"
     Site            order(335,367..368,375,378,381,404,412,418,428,433,435,
                     437,440..441)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:237997"
     Site            order(336,366)
                     /site_type="active"
                     /note="proteolytic cleavage site [active]"
                     /db_xref="CDD:237997"
     CDS             1..448
                     /gene="CASP1"
                     /gene_synonym="ICE; IL1BC; P45"
                     /coded_by="XM_054370127.1:93..1439"
                     /db_xref="GeneID:834"
                     /db_xref="HGNC:HGNC:1499"
                     /db_xref="MIM:147678"
ORIGIN      
        1 msrgipfykt igshetfiik rtawkknsth dsitshqipp ithedyynsr pcqkgrrsil
       61 svsvtqegrr ekpwptrvln keemekvkre natvmdktra lidsvipkga qacqicityi
      121 ceedsylagt lglsadqtsg nylnmqdsqg vlssfpapqa vqdnpampts sgsegnvklc
      181 sleeaqriwk qksaeiypim dkssrtrlal iicneefdsi prrtgaevdi tgmtmllqnl
      241 gysvdvkknl tasdmttele afahrpehkt sdstflvfms hgiregicgk khseqvpdil
      301 qlnaifnmln tkncpslkdk pkviiiqacr gdspgvvwfk dsvgvsgnls lptteefedd
      361 aikkahiekd fiafcsstpd nvswrhptmg svfigrlieh mqeyacscdv eeifrkvrfs
      421 feqpdgraqm pttervtltr cfylfpgh
//
LOCUS       XP_054226103             448 aa            linear   PRI 05-AUG-2025
DEFINITION  caspase-1 isoform X1 [Homo sapiens].
ACCESSION   XP_054226103
VERSION     XP_054226103.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370128.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..448
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..448
                     /product="caspase-1 isoform X1"
                     /calculated_mol_wt=50249
     Region          <77..131
                     /region_name="DD"
                     /note="Death Domain Superfamily of protein-protein
                     interaction domains; cl14633"
                     /db_xref="CDD:472698"
     Region          197..446
                     /region_name="CASc"
                     /note="Caspase, interleukin-1 beta converting enzyme (ICE)
                     homologues; smart00115"
                     /db_xref="CDD:214521"
     Site            order(223,282,327,334,382..387,391..392)
                     /site_type="other"
                     /note="substrate pocket [chemical binding]"
                     /db_xref="CDD:237997"
     Site            order(281,329)
                     /site_type="active"
                     /db_xref="CDD:237997"
     Site            order(335,367..368,375,378,381,404,412,418,428,433,435,
                     437,440..441)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:237997"
     Site            order(336,366)
                     /site_type="active"
                     /note="proteolytic cleavage site [active]"
                     /db_xref="CDD:237997"
     CDS             1..448
                     /gene="CASP1"
                     /gene_synonym="ICE; IL1BC; P45"
                     /coded_by="XM_054370128.1:94..1440"
                     /db_xref="GeneID:834"
                     /db_xref="HGNC:HGNC:1499"
                     /db_xref="MIM:147678"
ORIGIN      
        1 msrgipfykt igshetfiik rtawkknsth dsitshqipp ithedyynsr pcqkgrrsil
       61 svsvtqegrr ekpwptrvln keemekvkre natvmdktra lidsvipkga qacqicityi
      121 ceedsylagt lglsadqtsg nylnmqdsqg vlssfpapqa vqdnpampts sgsegnvklc
      181 sleeaqriwk qksaeiypim dkssrtrlal iicneefdsi prrtgaevdi tgmtmllqnl
      241 gysvdvkknl tasdmttele afahrpehkt sdstflvfms hgiregicgk khseqvpdil
      301 qlnaifnmln tkncpslkdk pkviiiqacr gdspgvvwfk dsvgvsgnls lptteefedd
      361 aikkahiekd fiafcsstpd nvswrhptmg svfigrlieh mqeyacscdv eeifrkvrfs
      421 feqpdgraqm pttervtltr cfylfpgh
//
LOCUS       XP_054226104             427 aa            linear   PRI 05-AUG-2025
DEFINITION  caspase-1 isoform X2 [Homo sapiens].
ACCESSION   XP_054226104
VERSION     XP_054226104.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370129.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..427
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..427
                     /product="caspase-1 isoform X2"
                     /calculated_mol_wt=47979
     Region          <77..131
                     /region_name="DD"
                     /note="Death Domain Superfamily of protein-protein
                     interaction domains; cl14633"
                     /db_xref="CDD:472698"
     Region          176..425
                     /region_name="CASc"
                     /note="Caspase, interleukin-1 beta converting enzyme (ICE)
                     homologues; smart00115"
                     /db_xref="CDD:214521"
     Site            order(202,261,306,313,361..366,370..371)
                     /site_type="other"
                     /note="substrate pocket [chemical binding]"
                     /db_xref="CDD:237997"
     Site            order(260,308)
                     /site_type="active"
                     /db_xref="CDD:237997"
     Site            order(314,346..347,354,357,360,383,391,397,407,412,414,
                     416,419..420)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:237997"
     Site            order(315,345)
                     /site_type="active"
                     /note="proteolytic cleavage site [active]"
                     /db_xref="CDD:237997"
     CDS             1..427
                     /gene="CASP1"
                     /gene_synonym="ICE; IL1BC; P45"
                     /coded_by="XM_054370129.1:97..1380"
                     /db_xref="GeneID:834"
                     /db_xref="HGNC:HGNC:1499"
                     /db_xref="MIM:147678"
ORIGIN      
        1 msrgipfykt igshetfiik rtawkknsth dsitshqipp ithedyynsr pcqkgrrsil
       61 svsvtqegrr ekpwptrvln keemekvkre natvmdktra lidsvipkga qacqicityi
      121 ceedsylagt lglsaapqav qdnpamptss gsegnvklcs leeaqriwkq ksaeiypimd
      181 kssrtrlali icneefdsip rrtgaevdit gmtmllqnlg ysvdvkknlt asdmttelea
      241 fahrpehkts dstflvfmsh giregicgkk hseqvpdilq lnaifnmlnt kncpslkdkp
      301 kviiiqacrg dspgvvwfkd svgvsgnlsl ptteefedda ikkahiekdf iafcsstpdn
      361 vswrhptmgs vfigrliehm qeyacscdve eifrkvrfsf eqpdgraqmp ttervtltrc
      421 fylfpgh
//
LOCUS       XP_054226105             374 aa            linear   PRI 05-AUG-2025
DEFINITION  caspase-1 isoform X4 [Homo sapiens].
ACCESSION   XP_054226105
VERSION     XP_054226105.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370130.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..374
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..374
                     /product="caspase-1 isoform X4"
                     /calculated_mol_wt=41630
     Region          <3..57
                     /region_name="DD"
                     /note="Death Domain Superfamily of protein-protein
                     interaction domains; cl14633"
                     /db_xref="CDD:472698"
     Region          123..372
                     /region_name="CASc"
                     /note="Caspase, interleukin-1 beta converting enzyme (ICE)
                     homologues; smart00115"
                     /db_xref="CDD:214521"
     Site            order(149,208,253,260,308..313,317..318)
                     /site_type="other"
                     /note="substrate pocket [chemical binding]"
                     /db_xref="CDD:237997"
     Site            order(207,255)
                     /site_type="active"
                     /db_xref="CDD:237997"
     Site            order(261,293..294,301,304,307,330,338,344,354,359,361,
                     363,366..367)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:237997"
     Site            order(262,292)
                     /site_type="active"
                     /note="proteolytic cleavage site [active]"
                     /db_xref="CDD:237997"
     CDS             1..374
                     /gene="CASP1"
                     /gene_synonym="ICE; IL1BC; P45"
                     /coded_by="XM_054370130.1:362..1486"
                     /db_xref="GeneID:834"
                     /db_xref="HGNC:HGNC:1499"
                     /db_xref="MIM:147678"
ORIGIN      
        1 mtrvlnkeem ekvkrenatv mdktralids vipkgaqacq icityiceed sylagtlgls
       61 adqtsgnyln mqdsqgvlss fpapqavqdn pamptssgse gnvklcslee aqriwkqksa
      121 eiypimdkss rtrlaliicn eefdsiprrt gaevditgmt mllqnlgysv dvkknltasd
      181 mtteleafah rpehktsdst flvfmshgir egicgkkhse qvpdilqlna ifnmlntknc
      241 pslkdkpkvi iiqacrgdsp gvvwfkdsvg vsgnlslptt eefeddaikk ahiekdfiaf
      301 csstpdnvsw rhptmgsvfi grliehmqey acscdveeif rkvrfsfeqp dgraqmptte
      361 rvtltrcfyl fpgh
//
LOCUS       XP_054226106             286 aa            linear   PRI 05-AUG-2025
DEFINITION  caspase-4 isoform X1 [Homo sapiens].
ACCESSION   XP_054226106
VERSION     XP_054226106.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370131.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..286
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..286
                     /product="caspase-4 isoform X1"
                     /calculated_mol_wt=32542
     Region          35..284
                     /region_name="CASc"
                     /note="Caspase, interleukin-1 beta converting enzyme (ICE)
                     homologues; smart00115"
                     /db_xref="CDD:214521"
     Site            order(61,120,165,172,220..225,229..230)
                     /site_type="other"
                     /note="substrate pocket [chemical binding]"
                     /db_xref="CDD:237997"
     Site            order(119,167)
                     /site_type="active"
                     /db_xref="CDD:237997"
     Site            order(173,205..206,213,216,219,242,250,256,266,271,273,
                     275,278..279)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:237997"
     Site            order(174,204)
                     /site_type="active"
                     /note="proteolytic cleavage site [active]"
                     /db_xref="CDD:237997"
     CDS             1..286
                     /gene="CASP4"
                     /gene_synonym="ICE(rel)II; ICEREL-II; ICH-2; Mih1;
                     Mih1/TX; TX"
                     /coded_by="XM_054370131.1:148..1008"
                     /db_xref="GeneID:837"
                     /db_xref="HGNC:HGNC:1505"
                     /db_xref="MIM:602664"
ORIGIN      
        1 meagppesge stdalklcph eeflrlcker aeeiypiker nnrtrlalii cntefdhlpp
       61 rngadfditg mkellegldy svdveenlta rdmesalraf atrpehkssd stflvlmshg
      121 ilegicgtvh dekkpdvlly dtifqifnnr nclslkdkpk viivqacrga nrgelwvrds
      181 paslevassq ssenleedav ykthvekdfi afcsstphnv swrdstmgsi fitqlitcfq
      241 kyswcchlee vfrkvqqsfe tprakaqmpt ierlsmtryf ylfpgn
//
LOCUS       XP_054226107             487 aa            linear   PRI 05-AUG-2025
DEFINITION  fermitin family homolog 3 isoform X1 [Homo sapiens].
ACCESSION   XP_054226107
VERSION     XP_054226107.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370132.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..487
                     /product="fermitin family homolog 3 isoform X1"
                     /calculated_mol_wt=55160
     Region          <35..74
                     /region_name="Ubl1_cv_Nsp3_N-like"
                     /note="first ubiquitin-like (Ubl) domain located at the
                     N-terminus of coronavirus SARS-CoV non-structural protein
                     3 (Nsp3) and related proteins; cl28922"
                     /db_xref="CDD:475130"
     Region          <38..>135
                     /region_name="B41"
                     /note="Band 4.1 homologues; smart00295"
                     /db_xref="CDD:214604"
     Region          170..298
                     /region_name="PH_fermitin"
                     /note="Fermitin family pleckstrin homology (PH) domain;
                     cd01237"
                     /db_xref="CDD:269943"
     Site            order(178,180,182,190..192,194,207,209,220)
                     /site_type="other"
                     /note="phosphoinositide binding site [chemical binding]"
                     /db_xref="CDD:269943"
     Region          <257..377
                     /region_name="FERM_M"
                     /note="FERM central domain; pfam00373"
                     /db_xref="CDD:459788"
     Region          372..463
                     /region_name="FERM_C_fermitin"
                     /note="FERM domain C-lobe of the Fermitin family; cd13205"
                     /db_xref="CDD:270026"
     Site            order(382,400,402,410)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:270026"
     Site            order(414,419..422,452,456,459..460)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270026"
     Site            452..463
                     /site_type="other"
                     /note="putative actin binding site 2 [polypeptide
                     binding]"
                     /db_xref="CDD:270026"
     CDS             1..487
                     /gene="FERMT3"
                     /gene_synonym="KIND3; MIG-2; MIG2B; UNC112C; URP2; URP2SF"
                     /coded_by="XM_054370132.1:120..1583"
                     /db_xref="GeneID:83706"
                     /db_xref="HGNC:HGNC:23151"
                     /db_xref="MIM:607901"
ORIGIN      
        1 mpahfsdsaq teacyhmlsr pqpppdplll qrlprpssls dktqlhsrwl dssrclmqqg
       61 ikagdalwlr fkyysffdld pktdpvrltq lyeqarwdll leeidcteee mmvfaalqyh
      121 inklsqsgev gepagtdpgl ddldvalsnl evklegsapt dvldslttip elkdhlrifr
      181 iprrprkltl kgyrqhwvvf kettlsyyks qdeapgdpiq qlnlkgcevv pdvnvsgqkf
      241 cikllvpspe gmseiylrcq deqqyarwma gcrlaskgrt madssytsev qailaflslq
      301 rtgsggpgnh phgpdasaeg lnpyglvapr fqrkfkakql tprileahqn vaqlslaeaq
      361 lrfiqawqsl pdfgisyvmv rfkgsrkdei lgiannrlir idlavgdvvk twrfsnmrqw
      421 nvnwdirqva iefdehinva fscvsascri vheyiggyif lstrerarge eldedlflql
      481 tggheaf
//
LOCUS       XP_054226108             254 aa            linear   PRI 05-AUG-2025
DEFINITION  tRNA 2'-phosphotransferase 1 isoform X1 [Homo sapiens].
ACCESSION   XP_054226108
VERSION     XP_054226108.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370133.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..254
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..254
                     /product="tRNA 2'-phosphotransferase 1 isoform X1"
                     /calculated_mol_wt=27682
     Region          31..204
                     /region_name="PTS_2-RNA"
                     /note="RNA 2'-phosphotransferase, Tpt1 / KptA family;
                     pfam01885"
                     /db_xref="CDD:460371"
     CDS             1..254
                     /gene="TRPT1"
                     /coded_by="XM_054370133.1:97..861"
                     /db_xref="GeneID:83707"
                     /db_xref="HGNC:HGNC:20316"
                     /db_xref="MIM:610470"
ORIGIN      
        1 mnfsgggrqe aagsrgrrap rpreqdrdvq lskalsyalr hgalklglpm gadgfvplgt
       61 llqlpqfrgf saedvqrvvd tnrkqrfalq lgdpstglli ranqghslqv pklelmplet
      121 pqalppmlvh gtfwkhwpsi llkglscqgr thihlapglp gdpgiisgmr shceiavfid
      181 gplalaadgi pffrsangvi ltpgntdgfl lpkyfkealq lrptrkplsl agdeetecqs
      241 spkhssrerr riqq
//
LOCUS       XP_054226109             253 aa            linear   PRI 05-AUG-2025
DEFINITION  tRNA 2'-phosphotransferase 1 isoform X2 [Homo sapiens].
ACCESSION   XP_054226109
VERSION     XP_054226109.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370134.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..253
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..253
                     /product="tRNA 2'-phosphotransferase 1 isoform X2"
                     /calculated_mol_wt=27611
     Region          31..203
                     /region_name="PTS_2-RNA"
                     /note="RNA 2'-phosphotransferase, Tpt1 / KptA family;
                     pfam01885"
                     /db_xref="CDD:460371"
     CDS             1..253
                     /gene="TRPT1"
                     /coded_by="XM_054370134.1:97..858"
                     /db_xref="GeneID:83707"
                     /db_xref="HGNC:HGNC:20316"
                     /db_xref="MIM:610470"
ORIGIN      
        1 mnfsgggrqe aagsrgrrap rpreqdrdvq lskalsyalr hgalklglpm gadgfvplgt
       61 llqlpqfrgf saedvqrvvd tnrkqrfalq lgdpstglli ranqghslqv pklelmplet
      121 pqalppmlvh gtfwkhwpsi llkglscqgr thihlapglp gdpgiisgmr shceiavfid
      181 gplaladgip ffrsangvil tpgntdgfll pkyfkealql rptrkplsla gdeetecqss
      241 pkhssrerrr iqq
//
LOCUS       XP_054226110             254 aa            linear   PRI 05-AUG-2025
DEFINITION  tRNA 2'-phosphotransferase 1 isoform X1 [Homo sapiens].
ACCESSION   XP_054226110
VERSION     XP_054226110.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370135.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..254
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..254
                     /product="tRNA 2'-phosphotransferase 1 isoform X1"
                     /calculated_mol_wt=27682
     Region          31..204
                     /region_name="PTS_2-RNA"
                     /note="RNA 2'-phosphotransferase, Tpt1 / KptA family;
                     pfam01885"
                     /db_xref="CDD:460371"
     CDS             1..254
                     /gene="TRPT1"
                     /coded_by="XM_054370135.1:57..821"
                     /db_xref="GeneID:83707"
                     /db_xref="HGNC:HGNC:20316"
                     /db_xref="MIM:610470"
ORIGIN      
        1 mnfsgggrqe aagsrgrrap rpreqdrdvq lskalsyalr hgalklglpm gadgfvplgt
       61 llqlpqfrgf saedvqrvvd tnrkqrfalq lgdpstglli ranqghslqv pklelmplet
      121 pqalppmlvh gtfwkhwpsi llkglscqgr thihlapglp gdpgiisgmr shceiavfid
      181 gplalaadgi pffrsangvi ltpgntdgfl lpkyfkealq lrptrkplsl agdeetecqs
      241 spkhssrerr riqq
//
LOCUS       XP_054226111             253 aa            linear   PRI 05-AUG-2025
DEFINITION  tRNA 2'-phosphotransferase 1 isoform X2 [Homo sapiens].
ACCESSION   XP_054226111
VERSION     XP_054226111.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370136.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..253
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..253
                     /product="tRNA 2'-phosphotransferase 1 isoform X2"
                     /calculated_mol_wt=27611
     Region          31..203
                     /region_name="PTS_2-RNA"
                     /note="RNA 2'-phosphotransferase, Tpt1 / KptA family;
                     pfam01885"
                     /db_xref="CDD:460371"
     CDS             1..253
                     /gene="TRPT1"
                     /coded_by="XM_054370136.1:77..838"
                     /db_xref="GeneID:83707"
                     /db_xref="HGNC:HGNC:20316"
                     /db_xref="MIM:610470"
ORIGIN      
        1 mnfsgggrqe aagsrgrrap rpreqdrdvq lskalsyalr hgalklglpm gadgfvplgt
       61 llqlpqfrgf saedvqrvvd tnrkqrfalq lgdpstglli ranqghslqv pklelmplet
      121 pqalppmlvh gtfwkhwpsi llkglscqgr thihlapglp gdpgiisgmr shceiavfid
      181 gplaladgip ffrsangvil tpgntdgfll pkyfkealql rptrkplsla gdeetecqss
      241 pkhssrerrr iqq
//
LOCUS       XP_054226112             216 aa            linear   PRI 05-AUG-2025
DEFINITION  tRNA 2'-phosphotransferase 1 isoform X3 [Homo sapiens].
ACCESSION   XP_054226112
VERSION     XP_054226112.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370137.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..216
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..216
                     /product="tRNA 2'-phosphotransferase 1 isoform X3"
                     /calculated_mol_wt=23435
     Region          31..186
                     /region_name="PTS_2-RNA"
                     /note="RNA 2'-phosphotransferase, Tpt1 / KptA family;
                     pfam01885"
                     /db_xref="CDD:460371"
     CDS             1..216
                     /gene="TRPT1"
                     /coded_by="XM_054370137.1:57..707"
                     /db_xref="GeneID:83707"
                     /db_xref="HGNC:HGNC:20316"
                     /db_xref="MIM:610470"
ORIGIN      
        1 mnfsgggrqe aagsrgrrap rpreqdrdvq lskalsyalr hgalklglpm gadgfvplgt
       61 llqlpqfrgf saedvqrvvd tnrkqrfalq lgdpstglli ranqghslqv pklelmplet
      121 pqalppmlvh gtfwkhwpsi llkglscqgr thihlapglp gdpgiisgmr shceiavfid
      181 gplalagkpl slagdeetec qsspkhssre rrriqq
//
LOCUS       XP_054226113             254 aa            linear   PRI 05-AUG-2025
DEFINITION  tRNA 2'-phosphotransferase 1 isoform X1 [Homo sapiens].
ACCESSION   XP_054226113
VERSION     XP_054226113.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370138.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..254
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..254
                     /product="tRNA 2'-phosphotransferase 1 isoform X1"
                     /calculated_mol_wt=27682
     Region          31..204
                     /region_name="PTS_2-RNA"
                     /note="RNA 2'-phosphotransferase, Tpt1 / KptA family;
                     pfam01885"
                     /db_xref="CDD:460371"
     CDS             1..254
                     /gene="TRPT1"
                     /coded_by="XM_054370138.1:147..911"
                     /db_xref="GeneID:83707"
                     /db_xref="HGNC:HGNC:20316"
                     /db_xref="MIM:610470"
ORIGIN      
        1 mnfsgggrqe aagsrgrrap rpreqdrdvq lskalsyalr hgalklglpm gadgfvplgt
       61 llqlpqfrgf saedvqrvvd tnrkqrfalq lgdpstglli ranqghslqv pklelmplet
      121 pqalppmlvh gtfwkhwpsi llkglscqgr thihlapglp gdpgiisgmr shceiavfid
      181 gplalaadgi pffrsangvi ltpgntdgfl lpkyfkealq lrptrkplsl agdeetecqs
      241 spkhssrerr riqq
//
LOCUS       XP_054226114             216 aa            linear   PRI 05-AUG-2025
DEFINITION  tRNA 2'-phosphotransferase 1 isoform X3 [Homo sapiens].
ACCESSION   XP_054226114
VERSION     XP_054226114.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370139.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..216
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..216
                     /product="tRNA 2'-phosphotransferase 1 isoform X3"
                     /calculated_mol_wt=23435
     Region          31..186
                     /region_name="PTS_2-RNA"
                     /note="RNA 2'-phosphotransferase, Tpt1 / KptA family;
                     pfam01885"
                     /db_xref="CDD:460371"
     CDS             1..216
                     /gene="TRPT1"
                     /coded_by="XM_054370139.1:135..785"
                     /db_xref="GeneID:83707"
                     /db_xref="HGNC:HGNC:20316"
                     /db_xref="MIM:610470"
ORIGIN      
        1 mnfsgggrqe aagsrgrrap rpreqdrdvq lskalsyalr hgalklglpm gadgfvplgt
       61 llqlpqfrgf saedvqrvvd tnrkqrfalq lgdpstglli ranqghslqv pklelmplet
      121 pqalppmlvh gtfwkhwpsi llkglscqgr thihlapglp gdpgiisgmr shceiavfid
      181 gplalagkpl slagdeetec qsspkhssre rrriqq
//
LOCUS       XP_054226115             205 aa            linear   PRI 05-AUG-2025
DEFINITION  tRNA 2'-phosphotransferase 1 isoform X4 [Homo sapiens].
ACCESSION   XP_054226115
VERSION     XP_054226115.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370140.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 1% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..205
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..205
                     /product="tRNA 2'-phosphotransferase 1 isoform X4"
                     /calculated_mol_wt=22367
     Region          1..155
                     /region_name="PTS_2-RNA"
                     /note="RNA 2'-phosphotransferase, Tpt1 / KptA family;
                     pfam01885"
                     /db_xref="CDD:460371"
     CDS             1..205
                     /gene="TRPT1"
                     /coded_by="XM_054370140.1:210..827"
                     /db_xref="GeneID:83707"
                     /db_xref="HGNC:HGNC:20316"
                     /db_xref="MIM:610470"
ORIGIN      
        1 mgadgfvplg tllqlpqfrg fsaedvqrvv dtnrkqrfal qlgdpstgll iranqghslq
       61 vpklelmple tpqalppmlv hgtfwkhwps illkglscqg rthihlapgl pgdpgiisgm
      121 rshceiavfi dgplalaadg ipffrsangv iltpgntdgf llpkyfkeal qlrptrkpls
      181 lagdeetecq sspkhssrer rriqq
//
LOCUS       XP_054226116             205 aa            linear   PRI 05-AUG-2025
DEFINITION  tRNA 2'-phosphotransferase 1 isoform X4 [Homo sapiens].
ACCESSION   XP_054226116
VERSION     XP_054226116.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370141.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..205
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..205
                     /product="tRNA 2'-phosphotransferase 1 isoform X4"
                     /calculated_mol_wt=22367
     Region          1..155
                     /region_name="PTS_2-RNA"
                     /note="RNA 2'-phosphotransferase, Tpt1 / KptA family;
                     pfam01885"
                     /db_xref="CDD:460371"
     CDS             1..205
                     /gene="TRPT1"
                     /coded_by="XM_054370141.1:198..815"
                     /db_xref="GeneID:83707"
                     /db_xref="HGNC:HGNC:20316"
                     /db_xref="MIM:610470"
ORIGIN      
        1 mgadgfvplg tllqlpqfrg fsaedvqrvv dtnrkqrfal qlgdpstgll iranqghslq
       61 vpklelmple tpqalppmlv hgtfwkhwps illkglscqg rthihlapgl pgdpgiisgm
      121 rshceiavfi dgplalaadg ipffrsangv iltpgntdgf llpkyfkeal qlrptrkpls
      181 lagdeetecq sspkhssrer rriqq
//
LOCUS       XP_054226117             204 aa            linear   PRI 05-AUG-2025
DEFINITION  tRNA 2'-phosphotransferase 1 isoform X5 [Homo sapiens].
ACCESSION   XP_054226117
VERSION     XP_054226117.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370142.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..204
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..204
                     /product="tRNA 2'-phosphotransferase 1 isoform X5"
                     /calculated_mol_wt=22296
     Region          1..154
                     /region_name="PTS_2-RNA"
                     /note="RNA 2'-phosphotransferase, Tpt1 / KptA family;
                     pfam01885"
                     /db_xref="CDD:460371"
     CDS             1..204
                     /gene="TRPT1"
                     /coded_by="XM_054370142.1:198..812"
                     /db_xref="GeneID:83707"
                     /db_xref="HGNC:HGNC:20316"
                     /db_xref="MIM:610470"
ORIGIN      
        1 mgadgfvplg tllqlpqfrg fsaedvqrvv dtnrkqrfal qlgdpstgll iranqghslq
       61 vpklelmple tpqalppmlv hgtfwkhwps illkglscqg rthihlapgl pgdpgiisgm
      121 rshceiavfi dgplaladgi pffrsangvi ltpgntdgfl lpkyfkealq lrptrkplsl
      181 agdeetecqs spkhssrerr riqq
//
LOCUS       XP_054226118             138 aa            linear   PRI 05-AUG-2025
DEFINITION  tRNA 2'-phosphotransferase 1 isoform X6 [Homo sapiens].
ACCESSION   XP_054226118
VERSION     XP_054226118.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370143.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..138
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..138
                     /product="tRNA 2'-phosphotransferase 1 isoform X6"
                     /calculated_mol_wt=15067
     Region          <2..88
                     /region_name="PTS_2-RNA"
                     /note="RNA 2'-phosphotransferase, Tpt1 / KptA family;
                     pfam01885"
                     /db_xref="CDD:460371"
     CDS             1..138
                     /gene="TRPT1"
                     /coded_by="XM_054370143.1:226..642"
                     /db_xref="GeneID:83707"
                     /db_xref="HGNC:HGNC:20316"
                     /db_xref="MIM:610470"
ORIGIN      
        1 mpletpqalp pmlvhgtfwk hwpsillkgl scqgrthihl apglpgdpgi isgmrshcei
       61 avfidgplal adgipffrsa ngviltpgnt dgfllpkyfk ealqlrptrk plslagdeet
      121 ecqsspkhss rerrriqq
//
LOCUS       XP_054226119             359 aa            linear   PRI 05-AUG-2025
DEFINITION  RNA-binding protein 4B isoform X1 [Homo sapiens].
ACCESSION   XP_054226119
VERSION     XP_054226119.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370144.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..359
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..359
                     /product="RNA-binding protein 4B isoform X1"
                     /calculated_mol_wt=40019
     Region          2..68
                     /region_name="RRM1_RBM4"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     RNA-binding protein 4 (RBM4); cd12606"
                     /db_xref="CDD:410018"
     Region          78..144
                     /region_name="RRM2_RBM4"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     RNA-binding protein 4 (RBM4); cd12607"
                     /db_xref="CDD:410019"
     Region          <145..>181
                     /region_name="PTZ00368"
                     /note="universal minicircle sequence binding protein
                     (UMSBP); Provisional"
                     /db_xref="CDD:173561"
     Region          161..176
                     /region_name="ZnF_C2HC"
                     /note="zinc finger; smart00343"
                     /db_xref="CDD:197667"
     CDS             1..359
                     /gene="RBM4B"
                     /gene_synonym="RBM30; RBM4L; ZCCHC15; ZCCHC21B; ZCRB3B"
                     /coded_by="XM_054370144.1:137..1216"
                     /db_xref="GeneID:83759"
                     /db_xref="HGNC:HGNC:28842"
                     /db_xref="MIM:621045"
ORIGIN      
        1 mvklfignlp reateqeirs lfeqygkvle cdiiknygfv hiedktaaed airnlhhykl
       61 hgvninveas knkskastkl hvgnisptct nqelrakfee ygpviecdiv kdyafvhmer
      121 aedaveairg ldntefqgkr mhvqlstsrl rtapgmgdqs gcyrcgkegh wskecpvdrt
      181 grvadfteqy neqygavrtp ytmgygesmy yndaygaldy ykryrvrsye avaaaaaasa
      241 ynyaeqtmsh lpqvqsttvt shlnstsvdp ydrhllpnsg aaatsaamaa aaattssyyg
      301 rdrsplrraa amlptvgegy gygpeselsq asaatrnsly dmaryereqy vdrarysaf
//
LOCUS       XP_054226120             359 aa            linear   PRI 05-AUG-2025
DEFINITION  RNA-binding protein 4B isoform X1 [Homo sapiens].
ACCESSION   XP_054226120
VERSION     XP_054226120.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370145.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..359
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..359
                     /product="RNA-binding protein 4B isoform X1"
                     /calculated_mol_wt=40019
     Region          2..68
                     /region_name="RRM1_RBM4"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     RNA-binding protein 4 (RBM4); cd12606"
                     /db_xref="CDD:410018"
     Region          78..144
                     /region_name="RRM2_RBM4"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     RNA-binding protein 4 (RBM4); cd12607"
                     /db_xref="CDD:410019"
     Region          <145..>181
                     /region_name="PTZ00368"
                     /note="universal minicircle sequence binding protein
                     (UMSBP); Provisional"
                     /db_xref="CDD:173561"
     Region          161..176
                     /region_name="ZnF_C2HC"
                     /note="zinc finger; smart00343"
                     /db_xref="CDD:197667"
     CDS             1..359
                     /gene="RBM4B"
                     /gene_synonym="RBM30; RBM4L; ZCCHC15; ZCCHC21B; ZCRB3B"
                     /coded_by="XM_054370145.1:137..1216"
                     /db_xref="GeneID:83759"
                     /db_xref="HGNC:HGNC:28842"
                     /db_xref="MIM:621045"
ORIGIN      
        1 mvklfignlp reateqeirs lfeqygkvle cdiiknygfv hiedktaaed airnlhhykl
       61 hgvninveas knkskastkl hvgnisptct nqelrakfee ygpviecdiv kdyafvhmer
      121 aedaveairg ldntefqgkr mhvqlstsrl rtapgmgdqs gcyrcgkegh wskecpvdrt
      181 grvadfteqy neqygavrtp ytmgygesmy yndaygaldy ykryrvrsye avaaaaaasa
      241 ynyaeqtmsh lpqvqsttvt shlnstsvdp ydrhllpnsg aaatsaamaa aaattssyyg
      301 rdrsplrraa amlptvgegy gygpeselsq asaatrnsly dmaryereqy vdrarysaf
//
LOCUS       XP_054226121             482 aa            linear   PRI 05-AUG-2025
DEFINITION  FERM domain-containing protein 8 isoform X1 [Homo sapiens].
ACCESSION   XP_054226121
VERSION     XP_054226121.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370146.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..482
                     /product="FERM domain-containing protein 8 isoform X1"
                     /calculated_mol_wt=52976
     Region          154..290
                     /region_name="FERM_M"
                     /note="FERM central domain; pfam00373"
                     /db_xref="CDD:459788"
     CDS             1..482
                     /gene="FRMD8"
                     /gene_synonym="FKSG44; iTAP"
                     /coded_by="XM_054370146.1:66..1514"
                     /db_xref="GeneID:83786"
                     /db_xref="HGNC:HGNC:25462"
                     /db_xref="MIM:618337"
ORIGIN      
        1 mtlkkrrsrt llereagtns prclpergrt pkewathglm avnldhaind apmdgtegsa
       61 gqpgpaersh rssvssvgar aadvlvylad dtvvplaven lpslsahelh ravrevlqlp
      121 dialdvfalw lvsplldepf lqfrrnvffp krrelqihde evlrllyeea kgnvlaaryp
      181 cdvedcealg alvcrvqlgp yqpgrpaacd lrekldsflp ahlckrgqsl faalrgrgar
      241 agpgeqglln ayrqvqevss dggceaalgt hyrayllkch elpfygcaff hgevdkpaqg
      301 flhrggrkpv svaislegvh vidsrekhvl lglrfqelsw dhtspeeeep ilwlefdgds
      361 egtpvnkllk iyskqaelms slieyciels qaaepagpqd satgspsdps sslapvqrpk
      421 lrrqgsvvss riqhlstidy vedgkgirrv kpkrttsffs rqlslgqgsy tvvqpgdsle
      481 qg
//
LOCUS       XP_054226122             477 aa            linear   PRI 05-AUG-2025
DEFINITION  FERM domain-containing protein 8 isoform X2 [Homo sapiens].
ACCESSION   XP_054226122
VERSION     XP_054226122.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370147.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..477
                     /product="FERM domain-containing protein 8 isoform X2"
                     /calculated_mol_wt=52450
     Region          149..285
                     /region_name="FERM_M"
                     /note="FERM central domain; pfam00373"
                     /db_xref="CDD:459788"
     CDS             1..477
                     /gene="FRMD8"
                     /gene_synonym="FKSG44; iTAP"
                     /coded_by="XM_054370147.1:116..1549"
                     /db_xref="GeneID:83786"
                     /db_xref="HGNC:HGNC:25462"
                     /db_xref="MIM:618337"
ORIGIN      
        1 mavnldhain dapmdgtegs agqpgpaers hrssvssvga raadvlvyla ddtvvplave
       61 nlpslsahel hravrevlql pdialdvfal wlvspllevq lkpkhqpykl grqwpelllr
      121 ftsapdddva mdepflqfrr nvffpkrrel qihdeevlrl lyeeakgnvl aarypcdved
      181 cealgalvcr vqlgpyqpgr paacdlrekl dsflpahlck rgqslfaalr grgaragpge
      241 qgllnayrqv qevssdggce aalgthyray llkchelpfy gcaffhgevd kpaqgflhrg
      301 grkpvsvais legvhvidsr ekhvllglrf qelswdhtsp eeeepilwle fdgdsegtpv
      361 nkllkiyskq aelmssliey cielsqaaep agpqdsatgs psdpssslap vqrpklrrqg
      421 svvssriqhl stidyvedgk girrvkpkrt tsffsrqlsl gqgsytvvqp gdsleqg
//
LOCUS       XP_054226123             986 aa            linear   PRI 05-AUG-2025
DEFINITION  FHF complex subunit HOOK-interacting protein 1B isoform X1 [Homo
            sapiens].
ACCESSION   XP_054226123
VERSION     XP_054226123.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370148.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..986
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..986
                     /product="FHF complex subunit HOOK-interacting protein 1B
                     isoform X1"
                     /calculated_mol_wt=106980
     Region          97..426
                     /region_name="RAI16-like"
                     /note="Retinoic acid induced 16-like protein; pfam10257"
                     /db_xref="CDD:370927"
     Region          449..>559
                     /region_name="KLF9_13_N-like"
                     /note="Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16,
                     and similar proteins; cl41730"
                     /db_xref="CDD:425361"
     Region          752..845
                     /region_name="DUF5917"
                     /note="Family of unknown function (DUF5917); pfam19314"
                     /db_xref="CDD:466037"
     Region          933..964
                     /region_name="KELAA"
                     /note="KELAA motif; pfam19311"
                     /db_xref="CDD:466035"
     CDS             1..986
                     /gene="FHIP1B"
                     /gene_synonym="C11orf56; FAM160A2; FHIP"
                     /coded_by="XM_054370148.1:238..3198"
                     /db_xref="GeneID:84067"
                     /db_xref="HGNC:HGNC:25378"
                     /db_xref="MIM:620229"
ORIGIN      
        1 mermnwlsrl asrgpghrip qganlqtpvm adpetclmvf knhwsqvvri lerqgpraap
       61 ggaddlsavr nhtyqmltll aedravpsap tgpgpllefa lhedlltrvl twqlqwdelg
      121 dgveerraeq lklfemlvse arqpllrhgp vrealltlld acgrpvpssp aldeglvlll
      181 sqlcvcvaqe psllefflqp ppepgaaprl llfsrlvpfv hregtlgqqa rdallllmal
      241 sagsptvgry iadhsyfcpv latglsalys slprkievpg ddwhclrred wlgvpalalf
      301 msslefcnav iqvahplvqk qlvdyihngf lvpvmgpalh ktsveemias taylelflrs
      361 isepallrtf lrflllhrhd thtildtlva rigsnsrlcm vslslfrtll nlscedvllq
      421 lvlrylvpcn hvmlsqkpav rdvdlygraa dkflsliprc crhhapsppr pehaswargg
      481 psretgrred itgpgspsvd sssvmtvprp stpsrlalfl rqqslggses pgpapcspgl
      541 saspasspgr rptpaeepge lednyleylr earrgvdrcv racrtwsapy dgerpspeps
      601 pfgsrtkkrs llpeedrnnv gegeeeelgr rgraggageg pghlpppqln gvpgswpega
      661 kkvrlvpkeg agellegise gmaglegfgq elrelevals nggtgsespl epplpleeee
      721 ayesftcppe ppgpflsspl rtlnqlpsqp ftgpfmavlf aklenmlqns vyvnflltgl
      781 vaqlachpqp llrsfllntn mvfqpsvksl lqvlgsvknk ienfaasqed fpallskakk
      841 yliargkldw aegpaagpap rrsdplvksr rpslgelllr hahsptrarq aaqlvlqpgr
      901 dgaglglsgg spgastpvll trggaperqg ealrvknavy cavifpeflk elaaisqaha
      961 vtspfllets eegsgplisg cgplnp
//
LOCUS       XP_054226124             986 aa            linear   PRI 05-AUG-2025
DEFINITION  FHF complex subunit HOOK-interacting protein 1B isoform X1 [Homo
            sapiens].
ACCESSION   XP_054226124
VERSION     XP_054226124.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370149.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..986
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..986
                     /product="FHF complex subunit HOOK-interacting protein 1B
                     isoform X1"
                     /calculated_mol_wt=106980
     Region          97..426
                     /region_name="RAI16-like"
                     /note="Retinoic acid induced 16-like protein; pfam10257"
                     /db_xref="CDD:370927"
     Region          449..>559
                     /region_name="KLF9_13_N-like"
                     /note="Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16,
                     and similar proteins; cl41730"
                     /db_xref="CDD:425361"
     Region          752..845
                     /region_name="DUF5917"
                     /note="Family of unknown function (DUF5917); pfam19314"
                     /db_xref="CDD:466037"
     Region          933..964
                     /region_name="KELAA"
                     /note="KELAA motif; pfam19311"
                     /db_xref="CDD:466035"
     CDS             1..986
                     /gene="FHIP1B"
                     /gene_synonym="C11orf56; FAM160A2; FHIP"
                     /coded_by="XM_054370149.1:297..3257"
                     /db_xref="GeneID:84067"
                     /db_xref="HGNC:HGNC:25378"
                     /db_xref="MIM:620229"
ORIGIN      
        1 mermnwlsrl asrgpghrip qganlqtpvm adpetclmvf knhwsqvvri lerqgpraap
       61 ggaddlsavr nhtyqmltll aedravpsap tgpgpllefa lhedlltrvl twqlqwdelg
      121 dgveerraeq lklfemlvse arqpllrhgp vrealltlld acgrpvpssp aldeglvlll
      181 sqlcvcvaqe psllefflqp ppepgaaprl llfsrlvpfv hregtlgqqa rdallllmal
      241 sagsptvgry iadhsyfcpv latglsalys slprkievpg ddwhclrred wlgvpalalf
      301 msslefcnav iqvahplvqk qlvdyihngf lvpvmgpalh ktsveemias taylelflrs
      361 isepallrtf lrflllhrhd thtildtlva rigsnsrlcm vslslfrtll nlscedvllq
      421 lvlrylvpcn hvmlsqkpav rdvdlygraa dkflsliprc crhhapsppr pehaswargg
      481 psretgrred itgpgspsvd sssvmtvprp stpsrlalfl rqqslggses pgpapcspgl
      541 saspasspgr rptpaeepge lednyleylr earrgvdrcv racrtwsapy dgerpspeps
      601 pfgsrtkkrs llpeedrnnv gegeeeelgr rgraggageg pghlpppqln gvpgswpega
      661 kkvrlvpkeg agellegise gmaglegfgq elrelevals nggtgsespl epplpleeee
      721 ayesftcppe ppgpflsspl rtlnqlpsqp ftgpfmavlf aklenmlqns vyvnflltgl
      781 vaqlachpqp llrsfllntn mvfqpsvksl lqvlgsvknk ienfaasqed fpallskakk
      841 yliargkldw aegpaagpap rrsdplvksr rpslgelllr hahsptrarq aaqlvlqpgr
      901 dgaglglsgg spgastpvll trggaperqg ealrvknavy cavifpeflk elaaisqaha
      961 vtspfllets eegsgplisg cgplnp
//
LOCUS       XP_054226125             986 aa            linear   PRI 05-AUG-2025
DEFINITION  FHF complex subunit HOOK-interacting protein 1B isoform X1 [Homo
            sapiens].
ACCESSION   XP_054226125
VERSION     XP_054226125.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370150.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..986
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..986
                     /product="FHF complex subunit HOOK-interacting protein 1B
                     isoform X1"
                     /calculated_mol_wt=106980
     Region          97..426
                     /region_name="RAI16-like"
                     /note="Retinoic acid induced 16-like protein; pfam10257"
                     /db_xref="CDD:370927"
     Region          449..>559
                     /region_name="KLF9_13_N-like"
                     /note="Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16,
                     and similar proteins; cl41730"
                     /db_xref="CDD:425361"
     Region          752..845
                     /region_name="DUF5917"
                     /note="Family of unknown function (DUF5917); pfam19314"
                     /db_xref="CDD:466037"
     Region          933..964
                     /region_name="KELAA"
                     /note="KELAA motif; pfam19311"
                     /db_xref="CDD:466035"
     CDS             1..986
                     /gene="FHIP1B"
                     /gene_synonym="C11orf56; FAM160A2; FHIP"
                     /coded_by="XM_054370150.1:203..3163"
                     /db_xref="GeneID:84067"
                     /db_xref="HGNC:HGNC:25378"
                     /db_xref="MIM:620229"
ORIGIN      
        1 mermnwlsrl asrgpghrip qganlqtpvm adpetclmvf knhwsqvvri lerqgpraap
       61 ggaddlsavr nhtyqmltll aedravpsap tgpgpllefa lhedlltrvl twqlqwdelg
      121 dgveerraeq lklfemlvse arqpllrhgp vrealltlld acgrpvpssp aldeglvlll
      181 sqlcvcvaqe psllefflqp ppepgaaprl llfsrlvpfv hregtlgqqa rdallllmal
      241 sagsptvgry iadhsyfcpv latglsalys slprkievpg ddwhclrred wlgvpalalf
      301 msslefcnav iqvahplvqk qlvdyihngf lvpvmgpalh ktsveemias taylelflrs
      361 isepallrtf lrflllhrhd thtildtlva rigsnsrlcm vslslfrtll nlscedvllq
      421 lvlrylvpcn hvmlsqkpav rdvdlygraa dkflsliprc crhhapsppr pehaswargg
      481 psretgrred itgpgspsvd sssvmtvprp stpsrlalfl rqqslggses pgpapcspgl
      541 saspasspgr rptpaeepge lednyleylr earrgvdrcv racrtwsapy dgerpspeps
      601 pfgsrtkkrs llpeedrnnv gegeeeelgr rgraggageg pghlpppqln gvpgswpega
      661 kkvrlvpkeg agellegise gmaglegfgq elrelevals nggtgsespl epplpleeee
      721 ayesftcppe ppgpflsspl rtlnqlpsqp ftgpfmavlf aklenmlqns vyvnflltgl
      781 vaqlachpqp llrsfllntn mvfqpsvksl lqvlgsvknk ienfaasqed fpallskakk
      841 yliargkldw aegpaagpap rrsdplvksr rpslgelllr hahsptrarq aaqlvlqpgr
      901 dgaglglsgg spgastpvll trggaperqg ealrvknavy cavifpeflk elaaisqaha
      961 vtspfllets eegsgplisg cgplnp
//
LOCUS       XP_054226126             972 aa            linear   PRI 05-AUG-2025
DEFINITION  FHF complex subunit HOOK-interacting protein 1B isoform X2 [Homo
            sapiens].
ACCESSION   XP_054226126
VERSION     XP_054226126.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370151.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..972
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..972
                     /product="FHF complex subunit HOOK-interacting protein 1B
                     isoform X2"
                     /calculated_mol_wt=105468
     Region          97..426
                     /region_name="RAI16-like"
                     /note="Retinoic acid induced 16-like protein; pfam10257"
                     /db_xref="CDD:370927"
     Region          <467..587
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          738..831
                     /region_name="DUF5917"
                     /note="Family of unknown function (DUF5917); pfam19314"
                     /db_xref="CDD:466037"
     Region          919..950
                     /region_name="KELAA"
                     /note="KELAA motif; pfam19311"
                     /db_xref="CDD:466035"
     CDS             1..972
                     /gene="FHIP1B"
                     /gene_synonym="C11orf56; FAM160A2; FHIP"
                     /coded_by="XM_054370151.1:297..3215"
                     /db_xref="GeneID:84067"
                     /db_xref="HGNC:HGNC:25378"
                     /db_xref="MIM:620229"
ORIGIN      
        1 mermnwlsrl asrgpghrip qganlqtpvm adpetclmvf knhwsqvvri lerqgpraap
       61 ggaddlsavr nhtyqmltll aedravpsap tgpgpllefa lhedlltrvl twqlqwdelg
      121 dgveerraeq lklfemlvse arqpllrhgp vrealltlld acgrpvpssp aldeglvlll
      181 sqlcvcvaqe psllefflqp ppepgaaprl llfsrlvpfv hregtlgqqa rdallllmal
      241 sagsptvgry iadhsyfcpv latglsalys slprkievpg ddwhclrred wlgvpalalf
      301 msslefcnav iqvahplvqk qlvdyihngf lvpvmgpalh ktsveemias taylelflrs
      361 isepallrtf lrflllhrhd thtildtlva rigsnsrlcm vslslfrtll nlscedvllq
      421 lvlrylvpcn hvmlsqkpav rdvdlygraa dkflsliprc crhhapsppr pehaswargp
      481 gspsvdsssv mtvprpstps rlalflrqqs lggsespgpa pcspglsasp asspgrrptp
      541 aeepgeledn yleylrearr gvdrcvracr twsapydger pspepspfgs rtkkrsllpe
      601 edrnnvgege eeelgrrgra ggagegpghl pppqlngvpg swpegakkvr lvpkegagel
      661 legisegmag legfgqelre levalsnggt gsespleppl pleeeeayes ftcppeppgp
      721 flssplrtln qlpsqpftgp fmavlfakle nmlqnsvyvn flltglvaql achpqpllrs
      781 fllntnmvfq psvksllqvl gsvknkienf aasqedfpal lskakkylia rgkldwaegp
      841 aagpaprrsd plvksrrpsl gelllrhahs ptrarqaaql vlqpgrdgag lglsggspga
      901 stpvlltrgg aperqgealr vknavycavi fpeflkelaa isqahavtsp flletseegs
      961 gplisgcgpl np
//
LOCUS       XP_054226127             972 aa            linear   PRI 05-AUG-2025
DEFINITION  FHF complex subunit HOOK-interacting protein 1B isoform X2 [Homo
            sapiens].
ACCESSION   XP_054226127
VERSION     XP_054226127.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370152.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..972
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..972
                     /product="FHF complex subunit HOOK-interacting protein 1B
                     isoform X2"
                     /calculated_mol_wt=105468
     Region          97..426
                     /region_name="RAI16-like"
                     /note="Retinoic acid induced 16-like protein; pfam10257"
                     /db_xref="CDD:370927"
     Region          <467..587
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          738..831
                     /region_name="DUF5917"
                     /note="Family of unknown function (DUF5917); pfam19314"
                     /db_xref="CDD:466037"
     Region          919..950
                     /region_name="KELAA"
                     /note="KELAA motif; pfam19311"
                     /db_xref="CDD:466035"
     CDS             1..972
                     /gene="FHIP1B"
                     /gene_synonym="C11orf56; FAM160A2; FHIP"
                     /coded_by="XM_054370152.1:238..3156"
                     /db_xref="GeneID:84067"
                     /db_xref="HGNC:HGNC:25378"
                     /db_xref="MIM:620229"
ORIGIN      
        1 mermnwlsrl asrgpghrip qganlqtpvm adpetclmvf knhwsqvvri lerqgpraap
       61 ggaddlsavr nhtyqmltll aedravpsap tgpgpllefa lhedlltrvl twqlqwdelg
      121 dgveerraeq lklfemlvse arqpllrhgp vrealltlld acgrpvpssp aldeglvlll
      181 sqlcvcvaqe psllefflqp ppepgaaprl llfsrlvpfv hregtlgqqa rdallllmal
      241 sagsptvgry iadhsyfcpv latglsalys slprkievpg ddwhclrred wlgvpalalf
      301 msslefcnav iqvahplvqk qlvdyihngf lvpvmgpalh ktsveemias taylelflrs
      361 isepallrtf lrflllhrhd thtildtlva rigsnsrlcm vslslfrtll nlscedvllq
      421 lvlrylvpcn hvmlsqkpav rdvdlygraa dkflsliprc crhhapsppr pehaswargp
      481 gspsvdsssv mtvprpstps rlalflrqqs lggsespgpa pcspglsasp asspgrrptp
      541 aeepgeledn yleylrearr gvdrcvracr twsapydger pspepspfgs rtkkrsllpe
      601 edrnnvgege eeelgrrgra ggagegpghl pppqlngvpg swpegakkvr lvpkegagel
      661 legisegmag legfgqelre levalsnggt gsespleppl pleeeeayes ftcppeppgp
      721 flssplrtln qlpsqpftgp fmavlfakle nmlqnsvyvn flltglvaql achpqpllrs
      781 fllntnmvfq psvksllqvl gsvknkienf aasqedfpal lskakkylia rgkldwaegp
      841 aagpaprrsd plvksrrpsl gelllrhahs ptrarqaaql vlqpgrdgag lglsggspga
      901 stpvlltrgg aperqgealr vknavycavi fpeflkelaa isqahavtsp flletseegs
      961 gplisgcgpl np
//
LOCUS       XP_054226128             972 aa            linear   PRI 05-AUG-2025
DEFINITION  FHF complex subunit HOOK-interacting protein 1B isoform X2 [Homo
            sapiens].
ACCESSION   XP_054226128
VERSION     XP_054226128.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370153.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..972
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..972
                     /product="FHF complex subunit HOOK-interacting protein 1B
                     isoform X2"
                     /calculated_mol_wt=105468
     Region          97..426
                     /region_name="RAI16-like"
                     /note="Retinoic acid induced 16-like protein; pfam10257"
                     /db_xref="CDD:370927"
     Region          <467..587
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          738..831
                     /region_name="DUF5917"
                     /note="Family of unknown function (DUF5917); pfam19314"
                     /db_xref="CDD:466037"
     Region          919..950
                     /region_name="KELAA"
                     /note="KELAA motif; pfam19311"
                     /db_xref="CDD:466035"
     CDS             1..972
                     /gene="FHIP1B"
                     /gene_synonym="C11orf56; FAM160A2; FHIP"
                     /coded_by="XM_054370153.1:205..3123"
                     /db_xref="GeneID:84067"
                     /db_xref="HGNC:HGNC:25378"
                     /db_xref="MIM:620229"
ORIGIN      
        1 mermnwlsrl asrgpghrip qganlqtpvm adpetclmvf knhwsqvvri lerqgpraap
       61 ggaddlsavr nhtyqmltll aedravpsap tgpgpllefa lhedlltrvl twqlqwdelg
      121 dgveerraeq lklfemlvse arqpllrhgp vrealltlld acgrpvpssp aldeglvlll
      181 sqlcvcvaqe psllefflqp ppepgaaprl llfsrlvpfv hregtlgqqa rdallllmal
      241 sagsptvgry iadhsyfcpv latglsalys slprkievpg ddwhclrred wlgvpalalf
      301 msslefcnav iqvahplvqk qlvdyihngf lvpvmgpalh ktsveemias taylelflrs
      361 isepallrtf lrflllhrhd thtildtlva rigsnsrlcm vslslfrtll nlscedvllq
      421 lvlrylvpcn hvmlsqkpav rdvdlygraa dkflsliprc crhhapsppr pehaswargp
      481 gspsvdsssv mtvprpstps rlalflrqqs lggsespgpa pcspglsasp asspgrrptp
      541 aeepgeledn yleylrearr gvdrcvracr twsapydger pspepspfgs rtkkrsllpe
      601 edrnnvgege eeelgrrgra ggagegpghl pppqlngvpg swpegakkvr lvpkegagel
      661 legisegmag legfgqelre levalsnggt gsespleppl pleeeeayes ftcppeppgp
      721 flssplrtln qlpsqpftgp fmavlfakle nmlqnsvyvn flltglvaql achpqpllrs
      781 fllntnmvfq psvksllqvl gsvknkienf aasqedfpal lskakkylia rgkldwaegp
      841 aagpaprrsd plvksrrpsl gelllrhahs ptrarqaaql vlqpgrdgag lglsggspga
      901 stpvlltrgg aperqgealr vknavycavi fpeflkelaa isqahavtsp flletseegs
      961 gplisgcgpl np
//
LOCUS       XP_054226129             868 aa            linear   PRI 05-AUG-2025
DEFINITION  FHF complex subunit HOOK-interacting protein 1B isoform X3 [Homo
            sapiens].
ACCESSION   XP_054226129
VERSION     XP_054226129.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370154.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..868
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..868
                     /product="FHF complex subunit HOOK-interacting protein 1B
                     isoform X3"
                     /calculated_mol_wt=94837
     Region          97..426
                     /region_name="RAI16-like"
                     /note="Retinoic acid induced 16-like protein; pfam10257"
                     /db_xref="CDD:370927"
     Region          449..>559
                     /region_name="KLF9_13_N-like"
                     /note="Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16,
                     and similar proteins; cl41730"
                     /db_xref="CDD:425361"
     Region          752..845
                     /region_name="DUF5917"
                     /note="Family of unknown function (DUF5917); pfam19314"
                     /db_xref="CDD:466037"
     CDS             1..868
                     /gene="FHIP1B"
                     /gene_synonym="C11orf56; FAM160A2; FHIP"
                     /coded_by="XM_054370154.1:285..2891"
                     /db_xref="GeneID:84067"
                     /db_xref="HGNC:HGNC:25378"
                     /db_xref="MIM:620229"
ORIGIN      
        1 mermnwlsrl asrgpghrip qganlqtpvm adpetclmvf knhwsqvvri lerqgpraap
       61 ggaddlsavr nhtyqmltll aedravpsap tgpgpllefa lhedlltrvl twqlqwdelg
      121 dgveerraeq lklfemlvse arqpllrhgp vrealltlld acgrpvpssp aldeglvlll
      181 sqlcvcvaqe psllefflqp ppepgaaprl llfsrlvpfv hregtlgqqa rdallllmal
      241 sagsptvgry iadhsyfcpv latglsalys slprkievpg ddwhclrred wlgvpalalf
      301 msslefcnav iqvahplvqk qlvdyihngf lvpvmgpalh ktsveemias taylelflrs
      361 isepallrtf lrflllhrhd thtildtlva rigsnsrlcm vslslfrtll nlscedvllq
      421 lvlrylvpcn hvmlsqkpav rdvdlygraa dkflsliprc crhhapsppr pehaswargg
      481 psretgrred itgpgspsvd sssvmtvprp stpsrlalfl rqqslggses pgpapcspgl
      541 saspasspgr rptpaeepge lednyleylr earrgvdrcv racrtwsapy dgerpspeps
      601 pfgsrtkkrs llpeedrnnv gegeeeelgr rgraggageg pghlpppqln gvpgswpega
      661 kkvrlvpkeg agellegise gmaglegfgq elrelevals nggtgsespl epplpleeee
      721 ayesftcppe ppgpflsspl rtlnqlpsqp ftgpfmavlf aklenmlqns vyvnflltgl
      781 vaqlachpqp llrsfllntn mvfqpsvksl lqvlgsvknk ienfaasqed fpallskakk
      841 yliargkldw aegpaagpap rrsdplep
//
LOCUS       XP_054226130             854 aa            linear   PRI 05-AUG-2025
DEFINITION  FHF complex subunit HOOK-interacting protein 1B isoform X4 [Homo
            sapiens].
ACCESSION   XP_054226130
VERSION     XP_054226130.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370155.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..854
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..854
                     /product="FHF complex subunit HOOK-interacting protein 1B
                     isoform X4"
                     /calculated_mol_wt=93325
     Region          97..426
                     /region_name="RAI16-like"
                     /note="Retinoic acid induced 16-like protein; pfam10257"
                     /db_xref="CDD:370927"
     Region          <467..587
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          738..831
                     /region_name="DUF5917"
                     /note="Family of unknown function (DUF5917); pfam19314"
                     /db_xref="CDD:466037"
     CDS             1..854
                     /gene="FHIP1B"
                     /gene_synonym="C11orf56; FAM160A2; FHIP"
                     /coded_by="XM_054370155.1:285..2849"
                     /db_xref="GeneID:84067"
                     /db_xref="HGNC:HGNC:25378"
                     /db_xref="MIM:620229"
ORIGIN      
        1 mermnwlsrl asrgpghrip qganlqtpvm adpetclmvf knhwsqvvri lerqgpraap
       61 ggaddlsavr nhtyqmltll aedravpsap tgpgpllefa lhedlltrvl twqlqwdelg
      121 dgveerraeq lklfemlvse arqpllrhgp vrealltlld acgrpvpssp aldeglvlll
      181 sqlcvcvaqe psllefflqp ppepgaaprl llfsrlvpfv hregtlgqqa rdallllmal
      241 sagsptvgry iadhsyfcpv latglsalys slprkievpg ddwhclrred wlgvpalalf
      301 msslefcnav iqvahplvqk qlvdyihngf lvpvmgpalh ktsveemias taylelflrs
      361 isepallrtf lrflllhrhd thtildtlva rigsnsrlcm vslslfrtll nlscedvllq
      421 lvlrylvpcn hvmlsqkpav rdvdlygraa dkflsliprc crhhapsppr pehaswargp
      481 gspsvdsssv mtvprpstps rlalflrqqs lggsespgpa pcspglsasp asspgrrptp
      541 aeepgeledn yleylrearr gvdrcvracr twsapydger pspepspfgs rtkkrsllpe
      601 edrnnvgege eeelgrrgra ggagegpghl pppqlngvpg swpegakkvr lvpkegagel
      661 legisegmag legfgqelre levalsnggt gsespleppl pleeeeayes ftcppeppgp
      721 flssplrtln qlpsqpftgp fmavlfakle nmlqnsvyvn flltglvaql achpqpllrs
      781 fllntnmvfq psvksllqvl gsvknkienf aasqedfpal lskakkylia rgkldwaegp
      841 aagpaprrsd plep
//
LOCUS       XP_054226131             824 aa            linear   PRI 05-AUG-2025
DEFINITION  FHF complex subunit HOOK-interacting protein 1B isoform X5 [Homo
            sapiens].
ACCESSION   XP_054226131
VERSION     XP_054226131.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370156.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..824
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..824
                     /product="FHF complex subunit HOOK-interacting protein 1B
                     isoform X5"
                     /calculated_mol_wt=90126
     Region          97..426
                     /region_name="RAI16-like"
                     /note="Retinoic acid induced 16-like protein; pfam10257"
                     /db_xref="CDD:370927"
     Region          449..>559
                     /region_name="KLF9_13_N-like"
                     /note="Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16,
                     and similar proteins; cl41730"
                     /db_xref="CDD:425361"
     Region          752..>813
                     /region_name="DUF5917"
                     /note="Family of unknown function (DUF5917); pfam19314"
                     /db_xref="CDD:466037"
     CDS             1..824
                     /gene="FHIP1B"
                     /gene_synonym="C11orf56; FAM160A2; FHIP"
                     /coded_by="XM_054370156.1:285..2759"
                     /db_xref="GeneID:84067"
                     /db_xref="HGNC:HGNC:25378"
                     /db_xref="MIM:620229"
ORIGIN      
        1 mermnwlsrl asrgpghrip qganlqtpvm adpetclmvf knhwsqvvri lerqgpraap
       61 ggaddlsavr nhtyqmltll aedravpsap tgpgpllefa lhedlltrvl twqlqwdelg
      121 dgveerraeq lklfemlvse arqpllrhgp vrealltlld acgrpvpssp aldeglvlll
      181 sqlcvcvaqe psllefflqp ppepgaaprl llfsrlvpfv hregtlgqqa rdallllmal
      241 sagsptvgry iadhsyfcpv latglsalys slprkievpg ddwhclrred wlgvpalalf
      301 msslefcnav iqvahplvqk qlvdyihngf lvpvmgpalh ktsveemias taylelflrs
      361 isepallrtf lrflllhrhd thtildtlva rigsnsrlcm vslslfrtll nlscedvllq
      421 lvlrylvpcn hvmlsqkpav rdvdlygraa dkflsliprc crhhapsppr pehaswargg
      481 psretgrred itgpgspsvd sssvmtvprp stpsrlalfl rqqslggses pgpapcspgl
      541 saspasspgr rptpaeepge lednyleylr earrgvdrcv racrtwsapy dgerpspeps
      601 pfgsrtkkrs llpeedrnnv gegeeeelgr rgraggageg pghlpppqln gvpgswpega
      661 kkvrlvpkeg agellegise gmaglegfgq elrelevals nggtgsespl epplpleeee
      721 ayesftcppe ppgpflsspl rtlnqlpsqp ftgpfmavlf aklenmlqns vyvnflltgl
      781 vaqlachpqp llrsfllntn mvfqpsvksl lqvcdacmhg cwal
//
LOCUS       XP_054226133             403 aa            linear   PRI 05-AUG-2025
DEFINITION  fatty acyl-CoA reductase 1 isoform X2 [Homo sapiens].
ACCESSION   XP_054226133
VERSION     XP_054226133.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370158.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..403
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..403
                     /product="fatty acyl-CoA reductase 1 isoform X2"
                     /calculated_mol_wt=45252
     Region          11..333
                     /region_name="FAR-N_SDR_e"
                     /note="fatty acyl CoA reductases (FARs), extended (e)
                     SDRs; cd05236"
                     /db_xref="CDD:187547"
     Site            order(17,19..22,44..46,111..113,130,151..153,204,208,
                     229..232)
                     /site_type="other"
                     /note="putative NAD(P) binding site [chemical binding]"
                     /db_xref="CDD:187547"
     Site            order(131,153,204,208)
                     /site_type="active"
                     /db_xref="CDD:187547"
     Site            order(153,204,231,243,259,265)
                     /site_type="other"
                     /note="putative substrate binding site [chemical binding]"
                     /db_xref="CDD:187547"
     CDS             1..403
                     /gene="FAR1"
                     /gene_synonym="CSPSD; MLSTD2; PFCRD; SDR10E1"
                     /coded_by="XM_054370158.1:147..1358"
                     /db_xref="GeneID:84188"
                     /db_xref="HGNC:HGNC:26222"
                     /db_xref="MIM:616107"
ORIGIN      
        1 mvsipeyyeg knvlltgatg flgkvllekl lrscpkvnsv yvlvrqkagq tpqerveevl
       61 sgklfdrlrd enpdfrekii ainseltqpk lalseedkev iidstniifh caatvrfnen
      121 lrdavqlnvi atrqlillaq qmknlevfmh vstayaycnr khidevvypp pvdpkklids
      181 lewmddglvn ditpkligdr pntyiytkal aeyvvqqega klnvaivrps ivgaswkepf
      241 pgwidnfngp sglfiaagkg ilrtirasnn aladlvpvdv vvnmslaaaw ysgvnrymrp
      301 rnimvynctt gstnpfhwge vgyyvshsfk mnplnqvfrc psfkfnsnsl shhyrkgvsh
      361 rvsallldct hvdrsetavr riavntlcig kvvaacwrde knh
//
LOCUS       XP_054226134             387 aa            linear   PRI 05-AUG-2025
DEFINITION  gamma-butyrobetaine dioxygenase isoform X1 [Homo sapiens].
ACCESSION   XP_054226134
VERSION     XP_054226134.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370159.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..387
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..387
                     /product="gamma-butyrobetaine dioxygenase isoform X1"
                     /calculated_mol_wt=44584
     Region          16..381
                     /region_name="carnitine_bodg"
                     /note="gamma-butyrobetaine hydroxylase; TIGR02409"
                     /db_xref="CDD:274118"
     Site            order(171..172,205,207,212,262,364,366)
                     /site_type="other"
                     /note="substrate binding pocket [chemical binding]"
                     /db_xref="CDD:238154"
     Site            order(202,204,229,347,360)
                     /site_type="active"
                     /db_xref="CDD:238154"
     Site            order(202,204,347)
                     /site_type="other"
                     /note="iron coordination sites [ion binding]"
                     /db_xref="CDD:238154"
     CDS             1..387
                     /gene="BBOX1"
                     /gene_synonym="BBH; BBOX; G-BBH; gamma-BBH"
                     /coded_by="XM_054370159.1:667..1830"
                     /db_xref="GeneID:8424"
                     /db_xref="HGNC:HGNC:964"
                     /db_xref="MIM:603312"
ORIGIN      
        1 mactiqkaea ldgahlmqil wydeeeslyp avwlrdncpc sdcyldsaka rkllvealdv
       61 nigikglifd rkkvyitwpd ehysefqadw lkkrcfskqa raklqrelff pecqywgsel
      121 qlptldfedv lrydehaykw lstlkkvgiv rltgasdkpg evsklgkrmg flyltfyght
      181 wqvqdkidan nvayttgkls fhtdypalhh ppgvqllhci kqtvtggdse ivdgfnvcqk
      241 lkknnpqafq ilsstfvdft digvdycdfs vqskhkiiel ddkgqvvrin fnnatrdtif
      301 dvpvervqpf yaalkefvdl mnskeskftf kmnpgdvitf dnwrllhgrr syeagteisr
      361 hlegayadwd vvmsrlrilr qrvengn
//
LOCUS       XP_054226135             387 aa            linear   PRI 05-AUG-2025
DEFINITION  gamma-butyrobetaine dioxygenase isoform X1 [Homo sapiens].
ACCESSION   XP_054226135
VERSION     XP_054226135.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370160.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..387
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..387
                     /product="gamma-butyrobetaine dioxygenase isoform X1"
                     /calculated_mol_wt=44584
     Region          16..381
                     /region_name="carnitine_bodg"
                     /note="gamma-butyrobetaine hydroxylase; TIGR02409"
                     /db_xref="CDD:274118"
     Site            order(171..172,205,207,212,262,364,366)
                     /site_type="other"
                     /note="substrate binding pocket [chemical binding]"
                     /db_xref="CDD:238154"
     Site            order(202,204,229,347,360)
                     /site_type="active"
                     /db_xref="CDD:238154"
     Site            order(202,204,347)
                     /site_type="other"
                     /note="iron coordination sites [ion binding]"
                     /db_xref="CDD:238154"
     CDS             1..387
                     /gene="BBOX1"
                     /gene_synonym="BBH; BBOX; G-BBH; gamma-BBH"
                     /coded_by="XM_054370160.1:250..1413"
                     /db_xref="GeneID:8424"
                     /db_xref="HGNC:HGNC:964"
                     /db_xref="MIM:603312"
ORIGIN      
        1 mactiqkaea ldgahlmqil wydeeeslyp avwlrdncpc sdcyldsaka rkllvealdv
       61 nigikglifd rkkvyitwpd ehysefqadw lkkrcfskqa raklqrelff pecqywgsel
      121 qlptldfedv lrydehaykw lstlkkvgiv rltgasdkpg evsklgkrmg flyltfyght
      181 wqvqdkidan nvayttgkls fhtdypalhh ppgvqllhci kqtvtggdse ivdgfnvcqk
      241 lkknnpqafq ilsstfvdft digvdycdfs vqskhkiiel ddkgqvvrin fnnatrdtif
      301 dvpvervqpf yaalkefvdl mnskeskftf kmnpgdvitf dnwrllhgrr syeagteisr
      361 hlegayadwd vvmsrlrilr qrvengn
//
LOCUS       XP_054226136             387 aa            linear   PRI 05-AUG-2025
DEFINITION  gamma-butyrobetaine dioxygenase isoform X1 [Homo sapiens].
ACCESSION   XP_054226136
VERSION     XP_054226136.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370161.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..387
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..387
                     /product="gamma-butyrobetaine dioxygenase isoform X1"
                     /calculated_mol_wt=44584
     Region          16..381
                     /region_name="carnitine_bodg"
                     /note="gamma-butyrobetaine hydroxylase; TIGR02409"
                     /db_xref="CDD:274118"
     Site            order(171..172,205,207,212,262,364,366)
                     /site_type="other"
                     /note="substrate binding pocket [chemical binding]"
                     /db_xref="CDD:238154"
     Site            order(202,204,229,347,360)
                     /site_type="active"
                     /db_xref="CDD:238154"
     Site            order(202,204,347)
                     /site_type="other"
                     /note="iron coordination sites [ion binding]"
                     /db_xref="CDD:238154"
     CDS             1..387
                     /gene="BBOX1"
                     /gene_synonym="BBH; BBOX; G-BBH; gamma-BBH"
                     /coded_by="XM_054370161.1:241..1404"
                     /db_xref="GeneID:8424"
                     /db_xref="HGNC:HGNC:964"
                     /db_xref="MIM:603312"
ORIGIN      
        1 mactiqkaea ldgahlmqil wydeeeslyp avwlrdncpc sdcyldsaka rkllvealdv
       61 nigikglifd rkkvyitwpd ehysefqadw lkkrcfskqa raklqrelff pecqywgsel
      121 qlptldfedv lrydehaykw lstlkkvgiv rltgasdkpg evsklgkrmg flyltfyght
      181 wqvqdkidan nvayttgkls fhtdypalhh ppgvqllhci kqtvtggdse ivdgfnvcqk
      241 lkknnpqafq ilsstfvdft digvdycdfs vqskhkiiel ddkgqvvrin fnnatrdtif
      301 dvpvervqpf yaalkefvdl mnskeskftf kmnpgdvitf dnwrllhgrr syeagteisr
      361 hlegayadwd vvmsrlrilr qrvengn
//
LOCUS       XP_054226137             518 aa            linear   PRI 05-AUG-2025
DEFINITION  BTB/POZ domain-containing protein 10 isoform X1 [Homo sapiens].
ACCESSION   XP_054226137
VERSION     XP_054226137.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370162.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..518
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..518
                     /product="BTB/POZ domain-containing protein 10 isoform X1"
                     /calculated_mol_wt=58380
     Region          173..282
                     /region_name="BTB_POZ_BTBD10_GMRP1"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in BTB/POZ
                     domain-containing protein 10 (BTBD10); cd18385"
                     /db_xref="CDD:349693"
     CDS             1..518
                     /gene="BTBD10"
                     /gene_synonym="GMRP-1; GMRP1"
                     /coded_by="XM_054370162.1:248..1804"
                     /db_xref="GeneID:84280"
                     /db_xref="HGNC:HGNC:21445"
                     /db_xref="MIM:615933"
ORIGIN      
        1 mpkdadlafs aslferaesl ytliskffsc fcvstlaytk gstssriakg gvdhtkmslh
       61 gasgghersr drrrssdrsr dsshertesq ltpcirnvts ptrqhhvere kdhsssrpss
      121 prpqkaspng sissagnssr nssqsssdgs cktagemvfv yenakegarn irtservtli
      181 vdntrfvvdp siftaqpntm lgrmfgsgre hnftrpnekg eyevaegigs tvfraildyy
      241 ktgiircpdg isipelreac dylcisfeys tikcrdlsal mhelsndgar rqfefyleem
      301 ilplmvasaq sgerechivv ltdddvvdwd eeyppqmgee ysqihllrei tqperekarn
      361 vhqsnslkfs ahledstcfi ystklyrffk yienrdvaks vlkerglkki rlgiegypty
      421 kekvkkrpgg rpeviynyvq rpfirmswek eegksrhvdf qcvksksitn laaaaadipq
      481 dqlvvmhptp qvdeldilpi hppsgnsdld pdaqnpml
//
LOCUS       XP_054226138             510 aa            linear   PRI 05-AUG-2025
DEFINITION  BTB/POZ domain-containing protein 10 isoform X2 [Homo sapiens].
ACCESSION   XP_054226138
VERSION     XP_054226138.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370163.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..510
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..510
                     /product="BTB/POZ domain-containing protein 10 isoform X2"
                     /calculated_mol_wt=57753
     Region          165..274
                     /region_name="BTB_POZ_BTBD10_GMRP1"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in BTB/POZ
                     domain-containing protein 10 (BTBD10); cd18385"
                     /db_xref="CDD:349693"
     CDS             1..510
                     /gene="BTBD10"
                     /gene_synonym="GMRP-1; GMRP1"
                     /coded_by="XM_054370163.1:189..1721"
                     /db_xref="GeneID:84280"
                     /db_xref="HGNC:HGNC:21445"
                     /db_xref="MIM:615933"
ORIGIN      
        1 magrphpydg nssdpenwdr klhsrprkly khsstssria kggvdhtkms lhgasggher
       61 srdrrrssdr srdssherte sqltpcirnv tsptrqhhve rekdhsssrp ssprpqkasp
      121 ngsissagns srnssqsssd gscktagemv fvyenakega rnirtservt livdntrfvv
      181 dpsiftaqpn tmlgrmfgsg rehnftrpne kgeyevaegi gstvfraild yyktgiircp
      241 dgisipelre acdylcisfe ystikcrdls almhelsndg arrqfefyle emilplmvas
      301 aqsgerechi vvltdddvvd wdeeyppqmg eeysqihllr eitqpereka rnvhqsnslk
      361 fsahledstc fiystklyrf fkyienrdva ksvlkerglk kirlgiegyp tykekvkkrp
      421 ggrpeviyny vqrpfirmsw ekeegksrhv dfqcvksksi tnlaaaaadi pqdqlvvmhp
      481 tpqvdeldil pihppsgnsd ldpdaqnpml
//
LOCUS       XP_054226139             510 aa            linear   PRI 05-AUG-2025
DEFINITION  BTB/POZ domain-containing protein 10 isoform X2 [Homo sapiens].
ACCESSION   XP_054226139
VERSION     XP_054226139.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370164.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..510
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..510
                     /product="BTB/POZ domain-containing protein 10 isoform X2"
                     /calculated_mol_wt=57753
     Region          165..274
                     /region_name="BTB_POZ_BTBD10_GMRP1"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in BTB/POZ
                     domain-containing protein 10 (BTBD10); cd18385"
                     /db_xref="CDD:349693"
     CDS             1..510
                     /gene="BTBD10"
                     /gene_synonym="GMRP-1; GMRP1"
                     /coded_by="XM_054370164.1:251..1783"
                     /db_xref="GeneID:84280"
                     /db_xref="HGNC:HGNC:21445"
                     /db_xref="MIM:615933"
ORIGIN      
        1 magrphpydg nssdpenwdr klhsrprkly khsstssria kggvdhtkms lhgasggher
       61 srdrrrssdr srdssherte sqltpcirnv tsptrqhhve rekdhsssrp ssprpqkasp
      121 ngsissagns srnssqsssd gscktagemv fvyenakega rnirtservt livdntrfvv
      181 dpsiftaqpn tmlgrmfgsg rehnftrpne kgeyevaegi gstvfraild yyktgiircp
      241 dgisipelre acdylcisfe ystikcrdls almhelsndg arrqfefyle emilplmvas
      301 aqsgerechi vvltdddvvd wdeeyppqmg eeysqihllr eitqpereka rnvhqsnslk
      361 fsahledstc fiystklyrf fkyienrdva ksvlkerglk kirlgiegyp tykekvkkrp
      421 ggrpeviyny vqrpfirmsw ekeegksrhv dfqcvksksi tnlaaaaadi pqdqlvvmhp
      481 tpqvdeldil pihppsgnsd ldpdaqnpml
//
LOCUS       XP_054226140             510 aa            linear   PRI 05-AUG-2025
DEFINITION  BTB/POZ domain-containing protein 10 isoform X2 [Homo sapiens].
ACCESSION   XP_054226140
VERSION     XP_054226140.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370165.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..510
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..510
                     /product="BTB/POZ domain-containing protein 10 isoform X2"
                     /calculated_mol_wt=57753
     Region          165..274
                     /region_name="BTB_POZ_BTBD10_GMRP1"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in BTB/POZ
                     domain-containing protein 10 (BTBD10); cd18385"
                     /db_xref="CDD:349693"
     CDS             1..510
                     /gene="BTBD10"
                     /gene_synonym="GMRP-1; GMRP1"
                     /coded_by="XM_054370165.1:349..1881"
                     /db_xref="GeneID:84280"
                     /db_xref="HGNC:HGNC:21445"
                     /db_xref="MIM:615933"
ORIGIN      
        1 magrphpydg nssdpenwdr klhsrprkly khsstssria kggvdhtkms lhgasggher
       61 srdrrrssdr srdssherte sqltpcirnv tsptrqhhve rekdhsssrp ssprpqkasp
      121 ngsissagns srnssqsssd gscktagemv fvyenakega rnirtservt livdntrfvv
      181 dpsiftaqpn tmlgrmfgsg rehnftrpne kgeyevaegi gstvfraild yyktgiircp
      241 dgisipelre acdylcisfe ystikcrdls almhelsndg arrqfefyle emilplmvas
      301 aqsgerechi vvltdddvvd wdeeyppqmg eeysqihllr eitqpereka rnvhqsnslk
      361 fsahledstc fiystklyrf fkyienrdva ksvlkerglk kirlgiegyp tykekvkkrp
      421 ggrpeviyny vqrpfirmsw ekeegksrhv dfqcvksksi tnlaaaaadi pqdqlvvmhp
      481 tpqvdeldil pihppsgnsd ldpdaqnpml
//
LOCUS       XP_054226141             475 aa            linear   PRI 05-AUG-2025
DEFINITION  BTB/POZ domain-containing protein 10 isoform X3 [Homo sapiens].
ACCESSION   XP_054226141
VERSION     XP_054226141.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370166.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..475
                     /product="BTB/POZ domain-containing protein 10 isoform X3"
                     /calculated_mol_wt=53648
     Region          165..274
                     /region_name="BTB_POZ_BTBD10_GMRP1"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in BTB/POZ
                     domain-containing protein 10 (BTBD10); cd18385"
                     /db_xref="CDD:349693"
     CDS             1..475
                     /gene="BTBD10"
                     /gene_synonym="GMRP-1; GMRP1"
                     /coded_by="XM_054370166.1:251..1678"
                     /db_xref="GeneID:84280"
                     /db_xref="HGNC:HGNC:21445"
                     /db_xref="MIM:615933"
ORIGIN      
        1 magrphpydg nssdpenwdr klhsrprkly khsstssria kggvdhtkms lhgasggher
       61 srdrrrssdr srdssherte sqltpcirnv tsptrqhhve rekdhsssrp ssprpqkasp
      121 ngsissagns srnssqsssd gscktagemv fvyenakega rnirtservt livdntrfvv
      181 dpsiftaqpn tmlgrmfgsg rehnftrpne kgeyevaegi gstvfraild yyktgiircp
      241 dgisipelre acdylcisfe ystikcrdls almhelsndg arrqfefyle emilplmvas
      301 aqsgerechi vvltdddvvd wdeeyppqmg eeysqiiyst klyrffkyie nrdvaksvlk
      361 erglkkirlg iegyptykek vkkrpggrpe viynyvqrpf irmswekeeg ksrhvdfqcv
      421 ksksitnlaa aaadipqdql vvmhptpqvd eldilpihpp sgnsdldpda qnpml
//
LOCUS       XP_054226142             475 aa            linear   PRI 05-AUG-2025
DEFINITION  BTB/POZ domain-containing protein 10 isoform X3 [Homo sapiens].
ACCESSION   XP_054226142
VERSION     XP_054226142.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370167.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..475
                     /product="BTB/POZ domain-containing protein 10 isoform X3"
                     /calculated_mol_wt=53648
     Region          165..274
                     /region_name="BTB_POZ_BTBD10_GMRP1"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in BTB/POZ
                     domain-containing protein 10 (BTBD10); cd18385"
                     /db_xref="CDD:349693"
     CDS             1..475
                     /gene="BTBD10"
                     /gene_synonym="GMRP-1; GMRP1"
                     /coded_by="XM_054370167.1:426..1853"
                     /db_xref="GeneID:84280"
                     /db_xref="HGNC:HGNC:21445"
                     /db_xref="MIM:615933"
ORIGIN      
        1 magrphpydg nssdpenwdr klhsrprkly khsstssria kggvdhtkms lhgasggher
       61 srdrrrssdr srdssherte sqltpcirnv tsptrqhhve rekdhsssrp ssprpqkasp
      121 ngsissagns srnssqsssd gscktagemv fvyenakega rnirtservt livdntrfvv
      181 dpsiftaqpn tmlgrmfgsg rehnftrpne kgeyevaegi gstvfraild yyktgiircp
      241 dgisipelre acdylcisfe ystikcrdls almhelsndg arrqfefyle emilplmvas
      301 aqsgerechi vvltdddvvd wdeeyppqmg eeysqiiyst klyrffkyie nrdvaksvlk
      361 erglkkirlg iegyptykek vkkrpggrpe viynyvqrpf irmswekeeg ksrhvdfqcv
      421 ksksitnlaa aaadipqdql vvmhptpqvd eldilpihpp sgnsdldpda qnpml
//
LOCUS       XP_054226143             462 aa            linear   PRI 05-AUG-2025
DEFINITION  BTB/POZ domain-containing protein 10 isoform X4 [Homo sapiens].
ACCESSION   XP_054226143
VERSION     XP_054226143.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370168.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..462
                     /product="BTB/POZ domain-containing protein 10 isoform X4"
                     /calculated_mol_wt=52312
     Region          117..226
                     /region_name="BTB_POZ_BTBD10_GMRP1"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in BTB/POZ
                     domain-containing protein 10 (BTBD10); cd18385"
                     /db_xref="CDD:349693"
     CDS             1..462
                     /gene="BTBD10"
                     /gene_synonym="GMRP-1; GMRP1"
                     /coded_by="XM_054370168.1:175..1563"
                     /db_xref="GeneID:84280"
                     /db_xref="HGNC:HGNC:21445"
                     /db_xref="MIM:615933"
ORIGIN      
        1 mslhgasggh ersrdrrrss drsrdssher tesqltpcir nvtsptrqhh verekdhsss
       61 rpssprpqka spngsissag nssrnssqss sdgscktage mvfvyenake garnirtser
      121 vtlivdntrf vvdpsiftaq pntmlgrmfg sgrehnftrp nekgeyevae gigstvfrai
      181 ldyyktgiir cpdgisipel reacdylcis feystikcrd lsalmhelsn dgarrqfefy
      241 leemilplmv asaqsgerec hivvltdddv vdwdeeyppq mgeeysqihl lreitqpere
      301 karnvhqsns lkfsahleds tcfiystkly rffkyienrd vaksvlkerg lkkirlgieg
      361 yptykekvkk rpggrpeviy nyvqrpfirm swekeegksr hvdfqcvksk sitnlaaaaa
      421 dipqdqlvvm hptpqvdeld ilpihppsgn sdldpdaqnp ml
//
LOCUS       XP_054226144             462 aa            linear   PRI 05-AUG-2025
DEFINITION  BTB/POZ domain-containing protein 10 isoform X4 [Homo sapiens].
ACCESSION   XP_054226144
VERSION     XP_054226144.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370169.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..462
                     /product="BTB/POZ domain-containing protein 10 isoform X4"
                     /calculated_mol_wt=52312
     Region          117..226
                     /region_name="BTB_POZ_BTBD10_GMRP1"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in BTB/POZ
                     domain-containing protein 10 (BTBD10); cd18385"
                     /db_xref="CDD:349693"
     CDS             1..462
                     /gene="BTBD10"
                     /gene_synonym="GMRP-1; GMRP1"
                     /coded_by="XM_054370169.1:237..1625"
                     /db_xref="GeneID:84280"
                     /db_xref="HGNC:HGNC:21445"
                     /db_xref="MIM:615933"
ORIGIN      
        1 mslhgasggh ersrdrrrss drsrdssher tesqltpcir nvtsptrqhh verekdhsss
       61 rpssprpqka spngsissag nssrnssqss sdgscktage mvfvyenake garnirtser
      121 vtlivdntrf vvdpsiftaq pntmlgrmfg sgrehnftrp nekgeyevae gigstvfrai
      181 ldyyktgiir cpdgisipel reacdylcis feystikcrd lsalmhelsn dgarrqfefy
      241 leemilplmv asaqsgerec hivvltdddv vdwdeeyppq mgeeysqihl lreitqpere
      301 karnvhqsns lkfsahleds tcfiystkly rffkyienrd vaksvlkerg lkkirlgieg
      361 yptykekvkk rpggrpeviy nyvqrpfirm swekeegksr hvdfqcvksk sitnlaaaaa
      421 dipqdqlvvm hptpqvdeld ilpihppsgn sdldpdaqnp ml
//
LOCUS       XP_054226145             367 aa            linear   PRI 05-AUG-2025
DEFINITION  BTB/POZ domain-containing protein 10 isoform X5 [Homo sapiens].
ACCESSION   XP_054226145
VERSION     XP_054226145.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370170.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..367
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..367
                     /product="BTB/POZ domain-containing protein 10 isoform X5"
                     /calculated_mol_wt=41064
     Region          173..282
                     /region_name="BTB_POZ_BTBD10_GMRP1"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in BTB/POZ
                     domain-containing protein 10 (BTBD10); cd18385"
                     /db_xref="CDD:349693"
     CDS             1..367
                     /gene="BTBD10"
                     /gene_synonym="GMRP-1; GMRP1"
                     /coded_by="XM_054370170.1:248..1351"
                     /db_xref="GeneID:84280"
                     /db_xref="HGNC:HGNC:21445"
                     /db_xref="MIM:615933"
ORIGIN      
        1 mpkdadlafs aslferaesl ytliskffsc fcvstlaytk gstssriakg gvdhtkmslh
       61 gasgghersr drrrssdrsr dsshertesq ltpcirnvts ptrqhhvere kdhsssrpss
      121 prpqkaspng sissagnssr nssqsssdgs cktagemvfv yenakegarn irtservtli
      181 vdntrfvvdp siftaqpntm lgrmfgsgre hnftrpnekg eyevaegigs tvfraildyy
      241 ktgiircpdg isipelreac dylcisfeys tikcrdlsal mhelsndgar rqfefyleem
      301 ilplmvasaq sgerechivv ltdddvvdwd eeyppqmgee ysqilgsllt mvfynmwnkk
      361 lnktqek
//
LOCUS       XP_054226146             359 aa            linear   PRI 05-AUG-2025
DEFINITION  BTB/POZ domain-containing protein 10 isoform X6 [Homo sapiens].
ACCESSION   XP_054226146
VERSION     XP_054226146.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370171.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..359
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..359
                     /product="BTB/POZ domain-containing protein 10 isoform X6"
                     /calculated_mol_wt=40437
     Region          165..274
                     /region_name="BTB_POZ_BTBD10_GMRP1"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in BTB/POZ
                     domain-containing protein 10 (BTBD10); cd18385"
                     /db_xref="CDD:349693"
     CDS             1..359
                     /gene="BTBD10"
                     /gene_synonym="GMRP-1; GMRP1"
                     /coded_by="XM_054370171.1:189..1268"
                     /db_xref="GeneID:84280"
                     /db_xref="HGNC:HGNC:21445"
                     /db_xref="MIM:615933"
ORIGIN      
        1 magrphpydg nssdpenwdr klhsrprkly khsstssria kggvdhtkms lhgasggher
       61 srdrrrssdr srdssherte sqltpcirnv tsptrqhhve rekdhsssrp ssprpqkasp
      121 ngsissagns srnssqsssd gscktagemv fvyenakega rnirtservt livdntrfvv
      181 dpsiftaqpn tmlgrmfgsg rehnftrpne kgeyevaegi gstvfraild yyktgiircp
      241 dgisipelre acdylcisfe ystikcrdls almhelsndg arrqfefyle emilplmvas
      301 aqsgerechi vvltdddvvd wdeeyppqmg eeysqilgsl ltmvfynmwn kklnktqek
//
LOCUS       XP_054226147             311 aa            linear   PRI 05-AUG-2025
DEFINITION  BTB/POZ domain-containing protein 10 isoform X7 [Homo sapiens].
ACCESSION   XP_054226147
VERSION     XP_054226147.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370172.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..311
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..311
                     /product="BTB/POZ domain-containing protein 10 isoform X7"
                     /calculated_mol_wt=34996
     Region          117..226
                     /region_name="BTB_POZ_BTBD10_GMRP1"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in BTB/POZ
                     domain-containing protein 10 (BTBD10); cd18385"
                     /db_xref="CDD:349693"
     CDS             1..311
                     /gene="BTBD10"
                     /gene_synonym="GMRP-1; GMRP1"
                     /coded_by="XM_054370172.1:175..1110"
                     /db_xref="GeneID:84280"
                     /db_xref="HGNC:HGNC:21445"
                     /db_xref="MIM:615933"
ORIGIN      
        1 mslhgasggh ersrdrrrss drsrdssher tesqltpcir nvtsptrqhh verekdhsss
       61 rpssprpqka spngsissag nssrnssqss sdgscktage mvfvyenake garnirtser
      121 vtlivdntrf vvdpsiftaq pntmlgrmfg sgrehnftrp nekgeyevae gigstvfrai
      181 ldyyktgiir cpdgisipel reacdylcis feystikcrd lsalmhelsn dgarrqfefy
      241 leemilplmv asaqsgerec hivvltdddv vdwdeeyppq mgeeysqilg slltmvfynm
      301 wnkklnktqe k
//
LOCUS       XP_054226148             427 aa            linear   PRI 05-AUG-2025
DEFINITION  BTB/POZ domain-containing protein 10 isoform X8 [Homo sapiens].
ACCESSION   XP_054226148
VERSION     XP_054226148.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370173.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..427
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..427
                     /product="BTB/POZ domain-containing protein 10 isoform X8"
                     /calculated_mol_wt=48207
     Region          117..226
                     /region_name="BTB_POZ_BTBD10_GMRP1"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in BTB/POZ
                     domain-containing protein 10 (BTBD10); cd18385"
                     /db_xref="CDD:349693"
     CDS             1..427
                     /gene="BTBD10"
                     /gene_synonym="GMRP-1; GMRP1"
                     /coded_by="XM_054370173.1:114..1397"
                     /db_xref="GeneID:84280"
                     /db_xref="HGNC:HGNC:21445"
                     /db_xref="MIM:615933"
ORIGIN      
        1 mslhgasggh ersrdrrrss drsrdssher tesqltpcir nvtsptrqhh verekdhsss
       61 rpssprpqka spngsissag nssrnssqss sdgscktage mvfvyenake garnirtser
      121 vtlivdntrf vvdpsiftaq pntmlgrmfg sgrehnftrp nekgeyevae gigstvfrai
      181 ldyyktgiir cpdgisipel reacdylcis feystikcrd lsalmhelsn dgarrqfefy
      241 leemilplmv asaqsgerec hivvltdddv vdwdeeyppq mgeeysqiiy stklyrffky
      301 ienrdvaksv lkerglkkir lgiegyptyk ekvkkrpggr peviynyvqr pfirmsweke
      361 egksrhvdfq cvksksitnl aaaaadipqd qlvvmhptpq vdeldilpih ppsgnsdldp
      421 daqnpml
//
LOCUS       XP_054226149             165 aa            linear   PRI 05-AUG-2025
DEFINITION  putative RNA-binding protein EIF1AD isoform X1 [Homo sapiens].
ACCESSION   XP_054226149
VERSION     XP_054226149.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370174.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..165
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..165
                     /product="putative RNA-binding protein EIF1AD isoform X1"
                     /calculated_mol_wt=18922
     Region          25..102
                     /region_name="S1_eIF1AD_like"
                     /note="eukaryotic translation initiation factor 1A domain
                     containing protein (eIF1AD)-like, S1-like RNA-binding
                     domain. eIF1AD is also known as MGC11102 protein. Little
                     is known about the function of eIF1AD. S1-like RNA-binding
                     domains are found in a wide...; cd05792"
                     /db_xref="CDD:240218"
     Site            order(33..34,38,52..55,58,63)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:240218"
     CDS             1..165
                     /gene="EIF1AD"
                     /gene_synonym="haponin; OBELIX"
                     /coded_by="XM_054370174.1:419..916"
                     /db_xref="GeneID:84285"
                     /db_xref="HGNC:HGNC:28147"
                     /db_xref="MIM:618473"
ORIGIN      
        1 msqatkrkhv vkevlgehiv psdqqqivrv lrtpgnnlhe vetaqgqrfl vsmpskyrkn
       61 iwikrgdfli vdpieegekv kaeisfvlck dhvrslqkeg fwpeafseva ekhnnrnrqt
      121 qpelpaepql sgeesssedd sdlfvntnrr qyheseeese eeeaa
//
LOCUS       XP_054226150             341 aa            linear   PRI 05-AUG-2025
DEFINITION  uridine diphosphate glucose pyrophosphatase NUDT22 isoform X1 [Homo
            sapiens].
ACCESSION   XP_054226150
VERSION     XP_054226150.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370175.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..341
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..341
                     /product="uridine diphosphate glucose pyrophosphatase
                     NUDT22 isoform X1"
                     /calculated_mol_wt=36615
     CDS             1..341
                     /gene="NUDT22"
                     /coded_by="XM_054370175.1:152..1177"
                     /db_xref="GeneID:84304"
                     /db_xref="HGNC:HGNC:28189"
ORIGIN      
        1 mscpvqtmdp evtlllqcpg gglpqeqiqa elspahdrrp lpggdeaita iwetrlkaqp
       61 wlfdapkfrl hsatlapigs rgpqlllrlg ltsyrdflgt nwsssaawlr qqgatdwgdt
      121 qayladplgv gaalataddf lvflrrsrqv aeapglvdvp gghpepqldl wlsvrertpd
      181 sgsltllhca tsdpqgqqal cpggspqhqd lagqlvvhel fssvlqeicd evnlplltls
      241 qplllgiarn etsagrasae fyvqcsltse qvrkhylsgg peahestgif fvetqnvrrl
      301 petemwaelc psakgaiily nrvqgsptga algspallpp l
//
LOCUS       XP_054226151             334 aa            linear   PRI 05-AUG-2025
DEFINITION  uridine diphosphate glucose pyrophosphatase NUDT22 isoform X2 [Homo
            sapiens].
ACCESSION   XP_054226151
VERSION     XP_054226151.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370176.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..334
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..334
                     /product="uridine diphosphate glucose pyrophosphatase
                     NUDT22 isoform X2"
                     /calculated_mol_wt=35868
     CDS             1..334
                     /gene="NUDT22"
                     /coded_by="XM_054370176.1:59..1063"
                     /db_xref="GeneID:84304"
                     /db_xref="HGNC:HGNC:28189"
ORIGIN      
        1 mdpevtlllq cpggglpqeq iqaelspahd rrplpggdea itaiwetrlk aqpwlfdapk
       61 frlhsatlap igsrgpqlll rlgltsyrdf lgtnwsssaa wlrqqgatdw gdtqayladp
      121 lgvgaalata ddflvflrrs rqvaeapglv dvpgghpepq ldlwlsvrer tpdsgsltll
      181 hcatsdpqgq qalcpggspq hqdlagqlvv helfssvlqe icdevnlpll tlsqplllgi
      241 arnetsagra saefyvqcsl tseqvrkhyl sggpeahest giffvetqnv rrlpetemwa
      301 elcpsakgai ilynrvqgsp tgaalgspal lppl
//
LOCUS       XP_054226152             334 aa            linear   PRI 05-AUG-2025
DEFINITION  uridine diphosphate glucose pyrophosphatase NUDT22 isoform X2 [Homo
            sapiens].
ACCESSION   XP_054226152
VERSION     XP_054226152.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370177.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..334
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..334
                     /product="uridine diphosphate glucose pyrophosphatase
                     NUDT22 isoform X2"
                     /calculated_mol_wt=35868
     CDS             1..334
                     /gene="NUDT22"
                     /coded_by="XM_054370177.1:350..1354"
                     /db_xref="GeneID:84304"
                     /db_xref="HGNC:HGNC:28189"
ORIGIN      
        1 mdpevtlllq cpggglpqeq iqaelspahd rrplpggdea itaiwetrlk aqpwlfdapk
       61 frlhsatlap igsrgpqlll rlgltsyrdf lgtnwsssaa wlrqqgatdw gdtqayladp
      121 lgvgaalata ddflvflrrs rqvaeapglv dvpgghpepq ldlwlsvrer tpdsgsltll
      181 hcatsdpqgq qalcpggspq hqdlagqlvv helfssvlqe icdevnlpll tlsqplllgi
      241 arnetsagra saefyvqcsl tseqvrkhyl sggpeahest giffvetqnv rrlpetemwa
      301 elcpsakgai ilynrvqgsp tgaalgspal lppl
//
LOCUS       XP_054226153             304 aa            linear   PRI 05-AUG-2025
DEFINITION  uridine diphosphate glucose pyrophosphatase NUDT22 isoform X3 [Homo
            sapiens].
ACCESSION   XP_054226153
VERSION     XP_054226153.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370178.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..304
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..304
                     /product="uridine diphosphate glucose pyrophosphatase
                     NUDT22 isoform X3"
                     /calculated_mol_wt=32570
     CDS             1..304
                     /gene="NUDT22"
                     /coded_by="XM_054370178.1:152..1066"
                     /db_xref="GeneID:84304"
                     /db_xref="HGNC:HGNC:28189"
ORIGIN      
        1 mscpvqtmdp evtlllqcpg gglpqeqiqa elspahdrrp lpggdeaita iwetrlkaqp
       61 wlfdapkfrl hsatlapigs rgpqlllrlg ltsyrdflgt nwsssaawlr qqgatdwgdt
      121 qayladplgv gaalataddf lvflrrsrqv aeapglvdvp gghpepqldl wlsvrertpd
      181 sgsltllhca tsdpqgqqal cpggspqhqd lagqlvvhel fssvlqeicd evnlplltls
      241 qplllgiarn etsagrasae fyvqcsltse qvrkhylsgg peahestgif fvetqrgsga
      301 eaap
//
LOCUS       XP_054226154             273 aa            linear   PRI 05-AUG-2025
DEFINITION  uridine diphosphate glucose pyrophosphatase NUDT22 isoform X5 [Homo
            sapiens].
ACCESSION   XP_054226154
VERSION     XP_054226154.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370179.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..273
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..273
                     /product="uridine diphosphate glucose pyrophosphatase
                     NUDT22 isoform X5"
                     /calculated_mol_wt=29163
     CDS             1..273
                     /gene="NUDT22"
                     /coded_by="XM_054370179.1:152..973"
                     /db_xref="GeneID:84304"
                     /db_xref="HGNC:HGNC:28189"
ORIGIN      
        1 mscpvqtmdp evtlllqcpg gglpqeqiqa elspahdrrp lpggdeaita iwetrlkaqp
       61 wlfdapkfrl hsatlapigs rgpqlllrlg ltsyrdflgt nwsssaawlr qqgatdwgdt
      121 qayladplgv gaalataddf lvflrrsrqv aeapglvdvp gghpepqalc pggspqhqdl
      181 agqlvvhelf ssvlqeicde vnlplltlsq plllgiarne tsagrasaef yvqcsltseq
      241 vrkhylsggp eahestgiff vetqrgsgae aap
//
LOCUS       XP_054226155             266 aa            linear   PRI 05-AUG-2025
DEFINITION  uridine diphosphate glucose pyrophosphatase NUDT22 isoform X7 [Homo
            sapiens].
ACCESSION   XP_054226155
VERSION     XP_054226155.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370180.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..266
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..266
                     /product="uridine diphosphate glucose pyrophosphatase
                     NUDT22 isoform X7"
                     /calculated_mol_wt=28416
     CDS             1..266
                     /gene="NUDT22"
                     /coded_by="XM_054370180.1:59..859"
                     /db_xref="GeneID:84304"
                     /db_xref="HGNC:HGNC:28189"
ORIGIN      
        1 mdpevtlllq cpggglpqeq iqaelspahd rrplpggdea itaiwetrlk aqpwlfdapk
       61 frlhsatlap igsrgpqlll rlgltsyrdf lgtnwsssaa wlrqqgatdw gdtqayladp
      121 lgvgaalata ddflvflrrs rqvaeapglv dvpgghpepq alcpggspqh qdlagqlvvh
      181 elfssvlqei cdevnlpllt lsqplllgia rnetsagras aefyvqcslt seqvrkhyls
      241 ggpeahestg iffvetqrgs gaeaap
//
LOCUS       XP_054226156             560 aa            linear   PRI 05-AUG-2025
DEFINITION  ADP-ribosylation factor GTPase-activating protein 2 isoform X1
            [Homo sapiens].
ACCESSION   XP_054226156
VERSION     XP_054226156.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370181.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..560
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..560
                     /product="ADP-ribosylation factor GTPase-activating
                     protein 2 isoform X1"
                     /calculated_mol_wt=60774
     Region          1..510
                     /region_name="PLN03114"
                     /note="ADP-ribosylation factor GTPase-activating protein
                     AGD10; Provisional"
                     /db_xref="CDD:178661"
     Region          5..124
                     /region_name="ArfGap_ArfGap2"
                     /note="Arf1 GTPase-activating protein 2; cd09029"
                     /db_xref="CDD:350086"
     Site            order(26,29,46,49,54)
                     /site_type="other"
                     /note="arginine finger"
                     /db_xref="CDD:350086"
     Site            order(26,29,46,49)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:350086"
     Region          <281..>344
                     /region_name="YqiK"
                     /note="Uncharacterized membrane protein YqiK, contains
                     Band7/PHB/SPFH domain [Function unknown]; COG2268"
                     /db_xref="CDD:441869"
     CDS             1..560
                     /gene="ARFGAP2"
                     /gene_synonym="IRZ; NBLA10535; ZFP289; ZNF289"
                     /coded_by="XM_054370181.1:27..1709"
                     /db_xref="GeneID:84364"
                     /db_xref="HGNC:HGNC:13504"
                     /db_xref="MIM:606908"
ORIGIN      
        1 maaepnktei qtlfkrlrav ptnkacfdcg aknpswasit ygvflcidcs gvhrslgvhl
       61 sfirstelds nwnwfqlrcm qvggnanata ffrqhgctan dantkynsra aqmyrekirq
      121 lgsaalarhg tdlwidnmss avpnhspekk dsdfftehtq vlvglgascq qewlteasvi
      181 wppfqppawd apatepsgtq qpapstessg laqpehgpnt dllgtspkas lesvylsakg
      241 alparelkss iigkkkpaaa kkglgakkgl gaqkvssqsf seierqaqva eklreqqaad
      301 akkqaeesmv asmrlayqel qidrkkeekk lqnlegkkre qaerlgmglv srssvshsvl
      361 semqvieqet pvsakssrsq ldlfddvgtf asgppkykdn pfslgesfgs rwdtdaawgm
      421 drveekepev tissirpise ratnrreves rssglessea rqkfagakai ssdmffgrev
      481 daeyearsrl qqlsgssais ssdlfgdmdg ahgagsvslg nvlptadiaq fkqgvksvag
      541 kmavlangvm nslqdrygsy
//
LOCUS       XP_054226157             549 aa            linear   PRI 05-AUG-2025
DEFINITION  ADP-ribosylation factor GTPase-activating protein 2 isoform X2
            [Homo sapiens].
ACCESSION   XP_054226157
VERSION     XP_054226157.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370182.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..549
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..549
                     /product="ADP-ribosylation factor GTPase-activating
                     protein 2 isoform X2"
                     /calculated_mol_wt=59718
     Region          1..499
                     /region_name="PLN03114"
                     /note="ADP-ribosylation factor GTPase-activating protein
                     AGD10; Provisional"
                     /db_xref="CDD:178661"
     Region          5..124
                     /region_name="ArfGap_ArfGap2"
                     /note="Arf1 GTPase-activating protein 2; cd09029"
                     /db_xref="CDD:350086"
     Site            order(26,29,46,49,54)
                     /site_type="other"
                     /note="arginine finger"
                     /db_xref="CDD:350086"
     Site            order(26,29,46,49)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:350086"
     Region          <270..>333
                     /region_name="YqiK"
                     /note="Uncharacterized membrane protein YqiK, contains
                     Band7/PHB/SPFH domain [Function unknown]; COG2268"
                     /db_xref="CDD:441869"
     CDS             1..549
                     /gene="ARFGAP2"
                     /gene_synonym="IRZ; NBLA10535; ZFP289; ZNF289"
                     /coded_by="XM_054370182.1:27..1676"
                     /db_xref="GeneID:84364"
                     /db_xref="HGNC:HGNC:13504"
                     /db_xref="MIM:606908"
ORIGIN      
        1 maaepnktei qtlfkrlrav ptnkacfdcg aknpswasit ygvflcidcs gvhrslgvhl
       61 sfirstelds nwnwfqlrcm qvggnanata ffrqhgctan dantkynsra aqmyrekirq
      121 lgsaalarhg tdlwidnmss avpnhspekk dsdfftehtq ewlteasviw ppfqppawda
      181 patepsgtqq papstessgl aqpehgpntd llgtspkasl esvylsakga lparelkssi
      241 igkkkpaaak kglgakkglg aqkvssqsfs eierqaqvae klreqqaada kkqaeesmva
      301 smrlayqelq idrkkeekkl qnlegkkreq aerlgmglvs rssvshsvls emqvieqetp
      361 vsakssrsql dlfddvgtfa sgppkykdnp fslgesfgsr wdtdaawgmd rveekepevt
      421 issirpiser atnrrevesr ssglessear qkfagakais sdmffgrevd aeyearsrlq
      481 qlsgssaiss sdlfgdmdga hgagsvslgn vlptadiaqf kqgvksvagk mavlangvmn
      541 slqdrygsy
//
LOCUS       XP_054226158             546 aa            linear   PRI 05-AUG-2025
DEFINITION  ADP-ribosylation factor GTPase-activating protein 2 isoform X3
            [Homo sapiens].
ACCESSION   XP_054226158
VERSION     XP_054226158.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370183.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..546
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..546
                     /product="ADP-ribosylation factor GTPase-activating
                     protein 2 isoform X3"
                     /calculated_mol_wt=59331
     Region          1..496
                     /region_name="PLN03114"
                     /note="ADP-ribosylation factor GTPase-activating protein
                     AGD10; Provisional"
                     /db_xref="CDD:178661"
     Region          5..124
                     /region_name="ArfGap_ArfGap2"
                     /note="Arf1 GTPase-activating protein 2; cd09029"
                     /db_xref="CDD:350086"
     Site            order(26,29,46,49,54)
                     /site_type="other"
                     /note="arginine finger"
                     /db_xref="CDD:350086"
     Site            order(26,29,46,49)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:350086"
     Region          <267..>330
                     /region_name="YqiK"
                     /note="Uncharacterized membrane protein YqiK, contains
                     Band7/PHB/SPFH domain [Function unknown]; COG2268"
                     /db_xref="CDD:441869"
     CDS             1..546
                     /gene="ARFGAP2"
                     /gene_synonym="IRZ; NBLA10535; ZFP289; ZNF289"
                     /coded_by="XM_054370183.1:27..1667"
                     /db_xref="GeneID:84364"
                     /db_xref="HGNC:HGNC:13504"
                     /db_xref="MIM:606908"
ORIGIN      
        1 maaepnktei qtlfkrlrav ptnkacfdcg aknpswasit ygvflcidcs gvhrslgvhl
       61 sfirstelds nwnwfqlrcm qvggnanata ffrqhgctan dantkynsra aqmyrekirq
      121 lgsaalarhg tdlwidnmss avpnhspekk dsdfftehtq vlvglgascq qewlteasvi
      181 wppfqppawd apatepsgtq qpapstessg laqpehgpnt dllgtspkas lelkssiigk
      241 kkpaaakkgl gakkglgaqk vssqsfseie rqaqvaeklr eqqaadakkq aeesmvasmr
      301 layqelqidr kkeekklqnl egkkreqaer lgmglvsrss vshsvlsemq vieqetpvsa
      361 kssrsqldlf ddvgtfasgp pkykdnpfsl gesfgsrwdt daawgmdrve ekepevtiss
      421 irpiseratn rrevesrssg lessearqkf agakaissdm ffgrevdaey earsrlqqls
      481 gssaisssdl fgdmdgahga gsvslgnvlp tadiaqfkqg vksvagkmav langvmnslq
      541 drygsy
//
LOCUS       XP_054226159             535 aa            linear   PRI 05-AUG-2025
DEFINITION  ADP-ribosylation factor GTPase-activating protein 2 isoform X4
            [Homo sapiens].
ACCESSION   XP_054226159
VERSION     XP_054226159.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370184.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..535
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..535
                     /product="ADP-ribosylation factor GTPase-activating
                     protein 2 isoform X4"
                     /calculated_mol_wt=58274
     Region          1..485
                     /region_name="PLN03114"
                     /note="ADP-ribosylation factor GTPase-activating protein
                     AGD10; Provisional"
                     /db_xref="CDD:178661"
     Region          5..124
                     /region_name="ArfGap_ArfGap2"
                     /note="Arf1 GTPase-activating protein 2; cd09029"
                     /db_xref="CDD:350086"
     Site            order(26,29,46,49,54)
                     /site_type="other"
                     /note="arginine finger"
                     /db_xref="CDD:350086"
     Site            order(26,29,46,49)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:350086"
     Region          <256..>319
                     /region_name="YqiK"
                     /note="Uncharacterized membrane protein YqiK, contains
                     Band7/PHB/SPFH domain [Function unknown]; COG2268"
                     /db_xref="CDD:441869"
     CDS             1..535
                     /gene="ARFGAP2"
                     /gene_synonym="IRZ; NBLA10535; ZFP289; ZNF289"
                     /coded_by="XM_054370184.1:27..1634"
                     /db_xref="GeneID:84364"
                     /db_xref="HGNC:HGNC:13504"
                     /db_xref="MIM:606908"
ORIGIN      
        1 maaepnktei qtlfkrlrav ptnkacfdcg aknpswasit ygvflcidcs gvhrslgvhl
       61 sfirstelds nwnwfqlrcm qvggnanata ffrqhgctan dantkynsra aqmyrekirq
      121 lgsaalarhg tdlwidnmss avpnhspekk dsdfftehtq ewlteasviw ppfqppawda
      181 patepsgtqq papstessgl aqpehgpntd llgtspkasl elkssiigkk kpaaakkglg
      241 akkglgaqkv ssqsfseier qaqvaeklre qqaadakkqa eesmvasmrl ayqelqidrk
      301 keekklqnle gkkreqaerl gmglvsrssv shsvlsemqv ieqetpvsak ssrsqldlfd
      361 dvgtfasgpp kykdnpfslg esfgsrwdtd aawgmdrvee kepevtissi rpiseratnr
      421 revesrssgl essearqkfa gakaissdmf fgrevdaeye arsrlqqlsg ssaisssdlf
      481 gdmdgahgag svslgnvlpt adiaqfkqgv ksvagkmavl angvmnslqd rygsy
//
LOCUS       XP_054226160             345 aa            linear   PRI 05-AUG-2025
DEFINITION  myb/SANT-like DNA-binding domain-containing protein 4 isoform X1
            [Homo sapiens].
ACCESSION   XP_054226160
VERSION     XP_054226160.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370185.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..345
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..345
                     /product="myb/SANT-like DNA-binding domain-containing
                     protein 4 isoform X1"
                     /calculated_mol_wt=41019
     Region          8..86
                     /region_name="Myb_DNA-bind_5"
                     /note="Myb/SANT-like DNA-binding domain; pfam13873"
                     /db_xref="CDD:433544"
     Region          <210..>341
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     CDS             1..345
                     /gene="MSANTD4"
                     /gene_synonym="KIAA1826"
                     /coded_by="XM_054370185.1:1526..2563"
                     /db_xref="GeneID:84437"
                     /db_xref="HGNC:HGNC:29383"
ORIGIN      
        1 mkqlkrkrks nfsvqetqtl lkeitkrkev ifskqlntti nvmkrmawee iaqcvnavge
       61 geqrtgtevk rryldwralm krkrmkanik lvgsgfplps sdlddsltee idekigfrnd
      121 anfdwqnvad frdaggslte vkveeeerdp qspefeieee eemlssvipd srrenelpdf
      181 phidefftln stpsrsayde phllvniekq klelekrrld ieaerlqvek erlqiekerl
      241 rhldmeherl qlekerlqie reklrlqivn sekpslenel gqgeksmlqp qdieteklkl
      301 ererlqlekd rlqflkfese klqiekerlq vekdrlriqk eghlq
//
LOCUS       XP_054226161             345 aa            linear   PRI 05-AUG-2025
DEFINITION  myb/SANT-like DNA-binding domain-containing protein 4 isoform X1
            [Homo sapiens].
ACCESSION   XP_054226161
VERSION     XP_054226161.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370186.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..345
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..345
                     /product="myb/SANT-like DNA-binding domain-containing
                     protein 4 isoform X1"
                     /calculated_mol_wt=41019
     Region          8..86
                     /region_name="Myb_DNA-bind_5"
                     /note="Myb/SANT-like DNA-binding domain; pfam13873"
                     /db_xref="CDD:433544"
     Region          <210..>341
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     CDS             1..345
                     /gene="MSANTD4"
                     /gene_synonym="KIAA1826"
                     /coded_by="XM_054370186.1:699..1736"
                     /db_xref="GeneID:84437"
                     /db_xref="HGNC:HGNC:29383"
ORIGIN      
        1 mkqlkrkrks nfsvqetqtl lkeitkrkev ifskqlntti nvmkrmawee iaqcvnavge
       61 geqrtgtevk rryldwralm krkrmkanik lvgsgfplps sdlddsltee idekigfrnd
      121 anfdwqnvad frdaggslte vkveeeerdp qspefeieee eemlssvipd srrenelpdf
      181 phidefftln stpsrsayde phllvniekq klelekrrld ieaerlqvek erlqiekerl
      241 rhldmeherl qlekerlqie reklrlqivn sekpslenel gqgeksmlqp qdieteklkl
      301 ererlqlekd rlqflkfese klqiekerlq vekdrlriqk eghlq
//
LOCUS       XP_054226162             345 aa            linear   PRI 05-AUG-2025
DEFINITION  myb/SANT-like DNA-binding domain-containing protein 4 isoform X1
            [Homo sapiens].
ACCESSION   XP_054226162
VERSION     XP_054226162.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370187.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..345
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..345
                     /product="myb/SANT-like DNA-binding domain-containing
                     protein 4 isoform X1"
                     /calculated_mol_wt=41019
     Region          8..86
                     /region_name="Myb_DNA-bind_5"
                     /note="Myb/SANT-like DNA-binding domain; pfam13873"
                     /db_xref="CDD:433544"
     Region          <210..>341
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     CDS             1..345
                     /gene="MSANTD4"
                     /gene_synonym="KIAA1826"
                     /coded_by="XM_054370187.1:340..1377"
                     /db_xref="GeneID:84437"
                     /db_xref="HGNC:HGNC:29383"
ORIGIN      
        1 mkqlkrkrks nfsvqetqtl lkeitkrkev ifskqlntti nvmkrmawee iaqcvnavge
       61 geqrtgtevk rryldwralm krkrmkanik lvgsgfplps sdlddsltee idekigfrnd
      121 anfdwqnvad frdaggslte vkveeeerdp qspefeieee eemlssvipd srrenelpdf
      181 phidefftln stpsrsayde phllvniekq klelekrrld ieaerlqvek erlqiekerl
      241 rhldmeherl qlekerlqie reklrlqivn sekpslenel gqgeksmlqp qdieteklkl
      301 ererlqlekd rlqflkfese klqiekerlq vekdrlriqk eghlq
//
LOCUS       XP_054226163             345 aa            linear   PRI 05-AUG-2025
DEFINITION  myb/SANT-like DNA-binding domain-containing protein 4 isoform X1
            [Homo sapiens].
ACCESSION   XP_054226163
VERSION     XP_054226163.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370188.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..345
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..345
                     /product="myb/SANT-like DNA-binding domain-containing
                     protein 4 isoform X1"
                     /calculated_mol_wt=41019
     Region          8..86
                     /region_name="Myb_DNA-bind_5"
                     /note="Myb/SANT-like DNA-binding domain; pfam13873"
                     /db_xref="CDD:433544"
     Region          <210..>341
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     CDS             1..345
                     /gene="MSANTD4"
                     /gene_synonym="KIAA1826"
                     /coded_by="XM_054370188.1:230..1267"
                     /db_xref="GeneID:84437"
                     /db_xref="HGNC:HGNC:29383"
ORIGIN      
        1 mkqlkrkrks nfsvqetqtl lkeitkrkev ifskqlntti nvmkrmawee iaqcvnavge
       61 geqrtgtevk rryldwralm krkrmkanik lvgsgfplps sdlddsltee idekigfrnd
      121 anfdwqnvad frdaggslte vkveeeerdp qspefeieee eemlssvipd srrenelpdf
      181 phidefftln stpsrsayde phllvniekq klelekrrld ieaerlqvek erlqiekerl
      241 rhldmeherl qlekerlqie reklrlqivn sekpslenel gqgeksmlqp qdieteklkl
      301 ererlqlekd rlqflkfese klqiekerlq vekdrlriqk eghlq
//
LOCUS       XP_054226164            1006 aa            linear   PRI 05-AUG-2025
DEFINITION  mastermind-like protein 2 isoform X1 [Homo sapiens].
ACCESSION   XP_054226164
VERSION     XP_054226164.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370189.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1006
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1006
                     /product="mastermind-like protein 2 isoform X1"
                     /calculated_mol_wt=110137
     Region          <204..436
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..1006
                     /gene="MAML2"
                     /gene_synonym="MAM-3; MAM2; MAM3; MLL-MAML2"
                     /coded_by="XM_054370189.1:67433..70453"
                     /db_xref="GeneID:84441"
                     /db_xref="HGNC:HGNC:16259"
                     /db_xref="MIM:607537"
ORIGIN      
        1 mlcesehqam iflcspkslq fpqnlqgslk rkqvvnlspa nskrpngfvd nsfldikrir
       61 vgenlsagqg glqinngqsq imsgtlpmsq aplrktntlp shthspgngl fnmglkevkk
      121 epgetlscsk hmdgqmtqen ifpnrygddp geqlmdpelq elfneltnis vppmsdlele
      181 nminatikqd dpfnidlgqq sqrstprpsl pmekivikse yspgltqgps gspqlrppsa
      241 gpafsmansa lstsspipsv pqsqaqpqtg sgasralpsw qevshaqqlk qiaanrqqha
      301 rmqqhqqqhq ptnwsalpss agpspgpfgq ekipspsfgq qtfspqsspm pgvaggsgqs
      361 kvmanymyka gpsaqgghld vlmqqkpqdl srsfinnphp ameprqgntk plfhfnsdqa
      421 nqqmpsvlps qnkpsllhyt qqqqqqqqqq qqqqqqqqqq qqqqqqqqqq qssisaqqqq
      481 qqqssisaqq qqqqqqqqqq qqqqqqqqqq qqqqqpssqp aqslpsqpll rsplplqqkl
      541 llqqmqnqpi agmgyqvsqq qrqdqhsvvg qntgpspspn pcsnpntgsg ymnsqqslln
      601 qqlmgkkqtl qrqimeqkqq lllqqqmlad aekiapqdqi nrhlsrpppd ykdqrrnvgn
      661 mqptaqysgg sstislnsnq alanpvstht iltpnsslls tshgtrmpsl stavqnmgmy
      721 gnlpcnqpnt ysvtsgmnql tqqrnpkqll anqnnpmmpr pptlgpsnnn nvatfgagsv
      781 gnsqqlrpnl thsmasmppq rtsnvmitsn ttapnwasqe gtskqqealt sagvrfptgt
      841 paaytpnqsl qqavgsqqfs qravappnql tpavqmrpmn qmsqtlngqt mgplrglnlr
      901 pnqlstqilp nlnqsgtgln qsrtginqpp sltpsnfpsp nqssrafqgt dhssdlafdf
      961 lsqqndnmgp alnsdadfid sllktepgnd dwmkdinlde ilgnns
//
LOCUS       XP_054226165             670 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase synoviolin isoform X1 [Homo sapiens].
ACCESSION   XP_054226165
VERSION     XP_054226165.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370190.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..670
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..670
                     /product="E3 ubiquitin-protein ligase synoviolin isoform
                     X1"
                     /calculated_mol_wt=74086
     Region          10..>333
                     /region_name="HRD1"
                     /note="HRD ubiquitin ligase complex, ER membrane component
                     [Posttranslational modification, protein turnover,
                     chaperones]; COG5243"
                     /db_xref="CDD:227568"
     CDS             1..670
                     /gene="SYVN1"
                     /gene_synonym="DER3; HRD1"
                     /coded_by="XM_054370190.1:297..2309"
                     /db_xref="GeneID:84447"
                     /db_xref="HGNC:HGNC:20738"
                     /db_xref="MIM:608046"
ORIGIN      
        1 mfrtavmmaa slaltgavva hayylkhqfy ptvvyltkss psmavlyiqa fvlvfllgkv
       61 mgkvffgqlr aaemehller swyavtetcl aftvfrddfs prfvalftll lflkcfhwla
      121 edrvdfmers pniswlfhcr ivslmfllgi ldflfvshay hsiltrgasv qlvfgfeyai
      181 lmtmvltifi kyvlhsvdlq senpwdnkav ymlytelftg fikvllymaf mtimikvhtf
      241 plfairpmyl amrqfkkavt daimsrrair nmntlypdat peelqamdnv ciicreemvt
      301 gakrlpcnhi fhtsclrswf qrqqtcptcr mdvlraslpa qsppppepad qgpppaphpp
      361 pllpqppnfp qgllppfppg mfplwppmgp fppvppppss geavappsts aaalsrpsga
      421 atttaagtsa taasatasgp gsgsapeagp apgfpfpppw mgmplpppfa fppmpvppag
      481 fagltpeelr alegherqhl earlqslrni htlldaamlq inqyltvlas lghwghkgts
      541 fytlfckahq gqenllnlgc qgqarlssll fpgppglplq stplrrlplq llllppppas
      601 laqrprpqpq epphqplkwk glqllsqwaq rrclrmespm qqssagaacr swslllptdt
      661 apaqpqpllf
//
LOCUS       XP_054226166             669 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase synoviolin isoform X2 [Homo sapiens].
ACCESSION   XP_054226166
VERSION     XP_054226166.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370191.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..669
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..669
                     /product="E3 ubiquitin-protein ligase synoviolin isoform
                     X2"
                     /calculated_mol_wt=74015
     Region          10..>333
                     /region_name="HRD1"
                     /note="HRD ubiquitin ligase complex, ER membrane component
                     [Posttranslational modification, protein turnover,
                     chaperones]; COG5243"
                     /db_xref="CDD:227568"
     CDS             1..669
                     /gene="SYVN1"
                     /gene_synonym="DER3; HRD1"
                     /coded_by="XM_054370191.1:297..2306"
                     /db_xref="GeneID:84447"
                     /db_xref="HGNC:HGNC:20738"
                     /db_xref="MIM:608046"
ORIGIN      
        1 mfrtavmmaa slaltgavva hayylkhqfy ptvvyltkss psmavlyiqa fvlvfllgkv
       61 mgkvffgqlr aaemehller swyavtetcl aftvfrddfs prfvalftll lflkcfhwla
      121 edrvdfmers pniswlfhcr ivslmfllgi ldflfvshay hsiltrgasv qlvfgfeyai
      181 lmtmvltifi kyvlhsvdlq senpwdnkav ymlytelftg fikvllymaf mtimikvhtf
      241 plfairpmyl amrqfkkavt daimsrrair nmntlypdat peelqamdnv ciicreemvt
      301 gakrlpcnhi fhtsclrswf qrqqtcptcr mdvlraslpa qsppppepad qgpppaphpp
      361 pllpqppnfp qgllppfppg mfplwppmgp fppvppppss geavappsts aalsrpsgaa
      421 tttaagtsat aasatasgpg sgsapeagpa pgfpfpppwm gmplpppfaf ppmpvppagf
      481 agltpeelra legherqhle arlqslrnih tlldaamlqi nqyltvlasl ghwghkgtsf
      541 ytlfckahqg qenllnlgcq gqarlssllf pgppglplqs tplrrlplql lllppppasl
      601 aqrprpqpqe pphqplkwkg lqllsqwaqr rclrmespmq qssagaacrs wslllptdta
      661 paqpqpllf
//
LOCUS       XP_054226167             617 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase synoviolin isoform X3 [Homo sapiens].
ACCESSION   XP_054226167
VERSION     XP_054226167.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370192.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..617
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..617
                     /product="E3 ubiquitin-protein ligase synoviolin isoform
                     X3"
                     /calculated_mol_wt=67554
     Region          10..>333
                     /region_name="HRD1"
                     /note="HRD ubiquitin ligase complex, ER membrane component
                     [Posttranslational modification, protein turnover,
                     chaperones]; COG5243"
                     /db_xref="CDD:227568"
     Region          <529..>601
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     CDS             1..617
                     /gene="SYVN1"
                     /gene_synonym="DER3; HRD1"
                     /coded_by="XM_054370192.1:315..2168"
                     /db_xref="GeneID:84447"
                     /db_xref="HGNC:HGNC:20738"
                     /db_xref="MIM:608046"
ORIGIN      
        1 mfrtavmmaa slaltgavva hayylkhqfy ptvvyltkss psmavlyiqa fvlvfllgkv
       61 mgkvffgqlr aaemehller swyavtetcl aftvfrddfs prfvalftll lflkcfhwla
      121 edrvdfmers pniswlfhcr ivslmfllgi ldflfvshay hsiltrgasv qlvfgfeyai
      181 lmtmvltifi kyvlhsvdlq senpwdnkav ymlytelftg fikvllymaf mtimikvhtf
      241 plfairpmyl amrqfkkavt daimsrrair nmntlypdat peelqamdnv ciicreemvt
      301 gakrlpcnhi fhtsclrswf qrqqtcptcr mdvlraslpa qsppppepad qgpppaphpp
      361 pllpqppnfp qgllppfppg mfplwppmgp fppvppppss geavappsts aaalsrpsga
      421 atttaagtsa taasatasgp gsgsapeagp apgfpfpppw mgmplpppfa fppmpvppag
      481 fagltpeelr alegherqhl earlqslrni htlldaamlq inqyltvlas lgpprpatsv
      541 nsteetattv vaaasstsip sseattptpg asppapemer ppapesvgte empedgepda
      601 aelrrrrlqk lespvah
//
LOCUS       XP_054226168             616 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase synoviolin isoform X4 [Homo sapiens].
ACCESSION   XP_054226168
VERSION     XP_054226168.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370193.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..616
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..616
                     /product="E3 ubiquitin-protein ligase synoviolin isoform
                     X4"
                     /calculated_mol_wt=67483
     Region          10..>333
                     /region_name="HRD1"
                     /note="HRD ubiquitin ligase complex, ER membrane component
                     [Posttranslational modification, protein turnover,
                     chaperones]; COG5243"
                     /db_xref="CDD:227568"
     Region          <528..>600
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     CDS             1..616
                     /gene="SYVN1"
                     /gene_synonym="DER3; HRD1"
                     /coded_by="XM_054370193.1:315..2165"
                     /db_xref="GeneID:84447"
                     /db_xref="HGNC:HGNC:20738"
                     /db_xref="MIM:608046"
ORIGIN      
        1 mfrtavmmaa slaltgavva hayylkhqfy ptvvyltkss psmavlyiqa fvlvfllgkv
       61 mgkvffgqlr aaemehller swyavtetcl aftvfrddfs prfvalftll lflkcfhwla
      121 edrvdfmers pniswlfhcr ivslmfllgi ldflfvshay hsiltrgasv qlvfgfeyai
      181 lmtmvltifi kyvlhsvdlq senpwdnkav ymlytelftg fikvllymaf mtimikvhtf
      241 plfairpmyl amrqfkkavt daimsrrair nmntlypdat peelqamdnv ciicreemvt
      301 gakrlpcnhi fhtsclrswf qrqqtcptcr mdvlraslpa qsppppepad qgpppaphpp
      361 pllpqppnfp qgllppfppg mfplwppmgp fppvppppss geavappsts aalsrpsgaa
      421 tttaagtsat aasatasgpg sgsapeagpa pgfpfpppwm gmplpppfaf ppmpvppagf
      481 agltpeelra legherqhle arlqslrnih tlldaamlqi nqyltvlasl gpprpatsvn
      541 steetattvv aaasstsips seattptpga sppapemerp papesvgtee mpedgepdaa
      601 elrrrrlqkl espvah
//
LOCUS       XP_054226170             803 aa            linear   PRI 05-AUG-2025
DEFINITION  kin of IRRE-like protein 3 isoform X2 [Homo sapiens].
ACCESSION   XP_054226170
VERSION     XP_054226170.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370195.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..803
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..803
                     /product="kin of IRRE-like protein 3 isoform X2"
                     /calculated_mol_wt=87774
     Region          54..143
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          65..69
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          73..81
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          110..114
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          124..129
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          135..139
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          149..246
                     /region_name="IgI_2_KIRREL3-like"
                     /note="Second immunoglobulin (Ig)-like domain of Kirrel
                     (kin of irregular chiasm-like) 3, and similar domains;
                     member of the I-set of Ig superfamily (IgSF) domains;
                     cd05759"
                     /db_xref="CDD:409416"
     Region          150..153
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409416"
     Region          156..160
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409416"
     Region          167..174
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409416"
     Region          179..184
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409416"
     Region          187..189
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409416"
     Region          192..199
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409416"
     Region          206..214
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409416"
     Region          223..231
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409416"
     Region          237..243
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409416"
     Region          <267..334
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          267..271
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          280..285
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          304..308
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          326..329
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          335..416
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          352..356
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          365..369
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          381..385
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          418..515
                     /region_name="IgI_5_KIRREL3"
                     /note="Fifth immunoglobulin (Ig)-like domain of Kirrel
                     (kin of irregular chiasm-like) 3 protein; member of the
                     I-set of Ig superfamily (IgSF) domains; cd05898"
                     /db_xref="CDD:409479"
     Region          419..423
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409479"
     Region          425..428
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409479"
     Region          436..443
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409479"
     Region          450..455
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409479"
     Region          457..460
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409479"
     Region          468..475
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409479"
     Region          478..485
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409479"
     Region          496..503
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409479"
     Region          506..513
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409479"
     CDS             1..803
                     /gene="KIRREL3"
                     /gene_synonym="KIRRE; MRD4; NEPH2; PRO4502"
                     /coded_by="XM_054370195.1:567..2978"
                     /db_xref="GeneID:84623"
                     /db_xref="HGNC:HGNC:23204"
                     /db_xref="MIM:607761"
ORIGIN      
        1 mkpfqldllf vcfflfsqel glqkrgcclv lgymakdkfr rmnegqvysf sqqpqdqvvv
       61 sgqpvtllca ipeydgfvlw ikdglalgvg rdlssypqyl vvgnhlsgeh hlkilraelq
      121 ddavyecqai qaairsrpar ltvlvppddp vilggpvisl ragdplnltc hadnakpaas
      181 iiwlrkgevi ngatysktll rdgkresivs tlfispgdve ngqsivcrat nkaipggket
      241 svtidiqhpp lvnlsvepqp vlednvvtfh csakanpavt qyrwakrgqi ikeasgevyr
      301 ttvdytyfse pvscevtnal gstnlsrtvd vyfgprmtte pqsllvdlgs daifscawtg
      361 npsltivwmk rgsgvvlsne ktltlksvrq edagkyvcra vvprvgager evtltvngpp
      421 iisstqtqha lhgekgqikc firstpppdr iawswkenvl esgtsgrytv etisteegvi
      481 stltisnivr adfqtiynct awnsfgsdte iirlkeqgse mksgagleae svpmaviigv
      541 avgagvaflv lmativafcc arsqrstggr sgisgrgtek karlrlprra nlkgvvsakn
      601 dirveivhke pasgregeeh stikqlmmdr gefqqdsvlk qlevlkeeek efqnlkdptn
      661 gyysvntfke hhstptisls scqpdlrpag kqrvptgmsf tniystlsgq grlydygqrf
      721 vlgmgsssie lcerefqrgs lsdsssfldt qcdssvsssg kqdgyvqfdk askasasssh
      781 hsqsssqnsd psrplqrrmq thv
//
LOCUS       XP_054226171             803 aa            linear   PRI 05-AUG-2025
DEFINITION  kin of IRRE-like protein 3 isoform X2 [Homo sapiens].
ACCESSION   XP_054226171
VERSION     XP_054226171.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370196.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..803
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..803
                     /product="kin of IRRE-like protein 3 isoform X2"
                     /calculated_mol_wt=87774
     Region          54..143
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          65..69
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          73..81
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          110..114
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          124..129
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          135..139
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          149..246
                     /region_name="IgI_2_KIRREL3-like"
                     /note="Second immunoglobulin (Ig)-like domain of Kirrel
                     (kin of irregular chiasm-like) 3, and similar domains;
                     member of the I-set of Ig superfamily (IgSF) domains;
                     cd05759"
                     /db_xref="CDD:409416"
     Region          150..153
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409416"
     Region          156..160
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409416"
     Region          167..174
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409416"
     Region          179..184
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409416"
     Region          187..189
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409416"
     Region          192..199
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409416"
     Region          206..214
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409416"
     Region          223..231
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409416"
     Region          237..243
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409416"
     Region          <267..334
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          267..271
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          280..285
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          304..308
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          326..329
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          335..416
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          352..356
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          365..369
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          381..385
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          418..515
                     /region_name="IgI_5_KIRREL3"
                     /note="Fifth immunoglobulin (Ig)-like domain of Kirrel
                     (kin of irregular chiasm-like) 3 protein; member of the
                     I-set of Ig superfamily (IgSF) domains; cd05898"
                     /db_xref="CDD:409479"
     Region          419..423
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409479"
     Region          425..428
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409479"
     Region          436..443
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409479"
     Region          450..455
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409479"
     Region          457..460
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409479"
     Region          468..475
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409479"
     Region          478..485
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409479"
     Region          496..503
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409479"
     Region          506..513
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409479"
     CDS             1..803
                     /gene="KIRREL3"
                     /gene_synonym="KIRRE; MRD4; NEPH2; PRO4502"
                     /coded_by="XM_054370196.1:444..2855"
                     /db_xref="GeneID:84623"
                     /db_xref="HGNC:HGNC:23204"
                     /db_xref="MIM:607761"
ORIGIN      
        1 mkpfqldllf vcfflfsqel glqkrgcclv lgymakdkfr rmnegqvysf sqqpqdqvvv
       61 sgqpvtllca ipeydgfvlw ikdglalgvg rdlssypqyl vvgnhlsgeh hlkilraelq
      121 ddavyecqai qaairsrpar ltvlvppddp vilggpvisl ragdplnltc hadnakpaas
      181 iiwlrkgevi ngatysktll rdgkresivs tlfispgdve ngqsivcrat nkaipggket
      241 svtidiqhpp lvnlsvepqp vlednvvtfh csakanpavt qyrwakrgqi ikeasgevyr
      301 ttvdytyfse pvscevtnal gstnlsrtvd vyfgprmtte pqsllvdlgs daifscawtg
      361 npsltivwmk rgsgvvlsne ktltlksvrq edagkyvcra vvprvgager evtltvngpp
      421 iisstqtqha lhgekgqikc firstpppdr iawswkenvl esgtsgrytv etisteegvi
      481 stltisnivr adfqtiynct awnsfgsdte iirlkeqgse mksgagleae svpmaviigv
      541 avgagvaflv lmativafcc arsqrstggr sgisgrgtek karlrlprra nlkgvvsakn
      601 dirveivhke pasgregeeh stikqlmmdr gefqqdsvlk qlevlkeeek efqnlkdptn
      661 gyysvntfke hhstptisls scqpdlrpag kqrvptgmsf tniystlsgq grlydygqrf
      721 vlgmgsssie lcerefqrgs lsdsssfldt qcdssvsssg kqdgyvqfdk askasasssh
      781 hsqsssqnsd psrplqrrmq thv
//
LOCUS       XP_054226172             791 aa            linear   PRI 05-AUG-2025
DEFINITION  kin of IRRE-like protein 3 isoform X3 [Homo sapiens].
ACCESSION   XP_054226172
VERSION     XP_054226172.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370197.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..791
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..791
                     /product="kin of IRRE-like protein 3 isoform X3"
                     /calculated_mol_wt=86656
     Region          54..143
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          65..69
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          73..81
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          110..114
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          124..129
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          135..139
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          149..246
                     /region_name="IgI_2_KIRREL3-like"
                     /note="Second immunoglobulin (Ig)-like domain of Kirrel
                     (kin of irregular chiasm-like) 3, and similar domains;
                     member of the I-set of Ig superfamily (IgSF) domains;
                     cd05759"
                     /db_xref="CDD:409416"
     Region          150..153
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409416"
     Region          156..160
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409416"
     Region          167..174
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409416"
     Region          179..184
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409416"
     Region          187..189
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409416"
     Region          192..199
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409416"
     Region          206..214
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409416"
     Region          223..231
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409416"
     Region          237..243
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409416"
     Region          <267..334
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          267..271
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          280..285
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          304..308
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          326..329
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          335..416
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          352..356
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          365..369
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          381..385
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          418..515
                     /region_name="IgI_5_KIRREL3"
                     /note="Fifth immunoglobulin (Ig)-like domain of Kirrel
                     (kin of irregular chiasm-like) 3 protein; member of the
                     I-set of Ig superfamily (IgSF) domains; cd05898"
                     /db_xref="CDD:409479"
     Region          419..423
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409479"
     Region          425..428
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409479"
     Region          436..443
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409479"
     Region          450..455
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409479"
     Region          457..460
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409479"
     Region          468..475
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409479"
     Region          478..485
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409479"
     Region          496..503
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409479"
     Region          506..513
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409479"
     CDS             1..791
                     /gene="KIRREL3"
                     /gene_synonym="KIRRE; MRD4; NEPH2; PRO4502"
                     /coded_by="XM_054370197.1:567..2942"
                     /db_xref="GeneID:84623"
                     /db_xref="HGNC:HGNC:23204"
                     /db_xref="MIM:607761"
ORIGIN      
        1 mkpfqldllf vcfflfsqel glqkrgcclv lgymakdkfr rmnegqvysf sqqpqdqvvv
       61 sgqpvtllca ipeydgfvlw ikdglalgvg rdlssypqyl vvgnhlsgeh hlkilraelq
      121 ddavyecqai qaairsrpar ltvlvppddp vilggpvisl ragdplnltc hadnakpaas
      181 iiwlrkgevi ngatysktll rdgkresivs tlfispgdve ngqsivcrat nkaipggket
      241 svtidiqhpp lvnlsvepqp vlednvvtfh csakanpavt qyrwakrgqi ikeasgevyr
      301 ttvdytyfse pvscevtnal gstnlsrtvd vyfgprmtte pqsllvdlgs daifscawtg
      361 npsltivwmk rgsgvvlsne ktltlksvrq edagkyvcra vvprvgager evtltvngpp
      421 iisstqtqha lhgekgqikc firstpppdr iawswkenvl esgtsgrytv etisteegvi
      481 stltisnivr adfqtiynct awnsfgsdte iirlkeqesv pmaviigvav gagvaflvlm
      541 ativafccar sqrstggrsg isgrgtekka rlrlprranl kgvvsakndi rveivhkepa
      601 sgregeehst ikqlmmdrge fqqdsvlkql evlkeeekef qnlkdptngy ysvntfkehh
      661 stptislssc qpdlrpagkq rvptgmsftn iystlsgqgr lydygqrfvl gmgsssielc
      721 erefqrgsls dsssfldtqc dssvsssgkq dgyvqfdkas kasassshhs qsssqnsdps
      781 rplqrrmqth v
//
LOCUS       XP_054226177             766 aa            linear   PRI 05-AUG-2025
DEFINITION  kin of IRRE-like protein 3 isoform X8 [Homo sapiens].
ACCESSION   XP_054226177
VERSION     XP_054226177.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370202.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..766
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..766
                     /product="kin of IRRE-like protein 3 isoform X8"
                     /calculated_mol_wt=84006
     Region          49..129
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          65..69
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          73..81
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          110..114
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          124..129
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          135..139
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          149..246
                     /region_name="IgI_2_KIRREL3-like"
                     /note="Second immunoglobulin (Ig)-like domain of Kirrel
                     (kin of irregular chiasm-like) 3, and similar domains;
                     member of the I-set of Ig superfamily (IgSF) domains;
                     cd05759"
                     /db_xref="CDD:409416"
     Region          150..153
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409416"
     Region          156..160
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409416"
     Region          167..174
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409416"
     Region          179..184
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409416"
     Region          187..189
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409416"
     Region          192..199
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409416"
     Region          206..214
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409416"
     Region          223..231
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409416"
     Region          237..243
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409416"
     Region          <267..334
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          267..271
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          280..285
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          304..308
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          326..329
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          335..416
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          352..356
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          365..369
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          381..385
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          418..515
                     /region_name="IgI_5_KIRREL3"
                     /note="Fifth immunoglobulin (Ig)-like domain of Kirrel
                     (kin of irregular chiasm-like) 3 protein; member of the
                     I-set of Ig superfamily (IgSF) domains; cd05898"
                     /db_xref="CDD:409479"
     Region          419..423
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409479"
     Region          425..428
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409479"
     Region          436..443
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409479"
     Region          450..455
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409479"
     Region          457..460
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409479"
     Region          468..475
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409479"
     Region          478..485
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409479"
     Region          496..503
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409479"
     Region          506..513
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409479"
     CDS             1..766
                     /gene="KIRREL3"
                     /gene_synonym="KIRRE; MRD4; NEPH2; PRO4502"
                     /coded_by="XM_054370202.1:567..2867"
                     /db_xref="GeneID:84623"
                     /db_xref="HGNC:HGNC:23204"
                     /db_xref="MIM:607761"
ORIGIN      
        1 mkpfqldllf vcfflfsqel glqkrgcclv lgymakdkfr rmnegqvysf sqqpqdqvvv
       61 sgqpvtllca ipeydgfvlw ikdglalgvg rdlssypqyl vvgnhlsgeh hlkilraelq
      121 ddavyecqai qaairsrpar ltvlvppddp vilggpvisl ragdplnltc hadnakpaas
      181 iiwlrkgevi ngatysktll rdgkresivs tlfispgdve ngqsivcrat nkaipggket
      241 svtidiqhpp lvnlsvepqp vlednvvtfh csakanpavt qyrwakrgqi ikeasgevyr
      301 ttvdytyfse pvscevtnal gstnlsrtvd vyfgprmtte pqsllvdlgs daifscawtg
      361 npsltivwmk rgsgvvlsne ktltlksvrq edagkyvcra vvprvgager evtltvngpp
      421 iisstqtqha lhgekgqikc firstpppdr iawswkenvl esgtsgrytv etisteegvi
      481 stltisnivr adfqtiynct awnsfgsdte iirlkeqesv pmaviigvav gagvaflvlm
      541 ativafccar sqrnlkgvvs akndirveiv hkepasgreg eehstikqlm mdrgefqqds
      601 vlkqlevlke eekefqnlkd ptngyysvnt fkehhstpti slsscqpdlr pagkqrvptg
      661 msftniystl sgqgrlydyg qrfvlgmgss sielcerefq rgslsdsssf ldtqcdssvs
      721 ssgkqdgyvq fdkaskasas sshhsqsssq nsdpsrplqr rmqthv
//
LOCUS       XP_054226178             589 aa            linear   PRI 05-AUG-2025
DEFINITION  kin of IRRE-like protein 3 isoform X6 [Homo sapiens].
ACCESSION   XP_054226178
VERSION     XP_054226178.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370203.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..589
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..589
                     /product="kin of IRRE-like protein 3 isoform X6"
                     /calculated_mol_wt=64384
     Region          <8..57
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          21..25
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          35..40
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          50..53
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          <78..145
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          78..82
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          91..96
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          115..119
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          137..140
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          146..227
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          163..167
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          176..180
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          192..196
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          229..326
                     /region_name="IgI_5_KIRREL3"
                     /note="Fifth immunoglobulin (Ig)-like domain of Kirrel
                     (kin of irregular chiasm-like) 3 protein; member of the
                     I-set of Ig superfamily (IgSF) domains; cd05898"
                     /db_xref="CDD:409479"
     Region          230..234
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409479"
     Region          236..239
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409479"
     Region          247..254
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409479"
     Region          261..266
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409479"
     Region          268..271
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409479"
     Region          279..286
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409479"
     Region          289..296
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409479"
     Region          307..314
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409479"
     Region          317..324
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409479"
     CDS             1..589
                     /gene="KIRREL3"
                     /gene_synonym="KIRRE; MRD4; NEPH2; PRO4502"
                     /coded_by="XM_054370203.1:3975..5744"
                     /db_xref="GeneID:84623"
                     /db_xref="HGNC:HGNC:23204"
                     /db_xref="MIM:607761"
ORIGIN      
        1 mntqrqkqtl lrdgkresiv stlfispgdv engqsivcra tnkaipggke tsvtidiqhp
       61 plvnlsvepq pvlednvvtf hcsakanpav tqyrwakrgq iikeasgevy rttvdytyfs
      121 epvscevtna lgstnlsrtv dvyfgprmtt epqsllvdlg sdaifscawt gnpsltivwm
      181 krgsgvvlsn ektltlksvr qedagkyvcr avvprvgage revtltvngp piisstqtqh
      241 alhgekgqik cfirstpppd riawswkenv lesgtsgryt vetisteegv istltisniv
      301 radfqtiync tawnsfgsdt eiirlkeqgs emksgaglea esvpmaviig vavgagvafl
      361 vlmativafc carsqrnlkg vvsakndirv eivhkepasg regeehstik qlmmdrgefq
      421 qdsvlkqlev lkeeekefqn lkdptngyys vntfkehhst ptislsscqp dlrpagkqrv
      481 ptgmsftniy stlsgqgrly dygqrfvlgm gsssielcer efqrgslsds ssfldtqcds
      541 svsssgkqdg yvqfdkaska sassshhsqs ssqnsdpsrp lqrrmqthv
//
LOCUS       XP_054226179             358 aa            linear   PRI 05-AUG-2025
DEFINITION  diacylglycerol O-acyltransferase 2 isoform X1 [Homo sapiens].
ACCESSION   XP_054226179
VERSION     XP_054226179.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370204.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..358
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..358
                     /product="diacylglycerol O-acyltransferase 2 isoform X1"
                     /calculated_mol_wt=40377
     Region          62..358
                     /region_name="DAGAT"
                     /note="Diacylglycerol acyltransferase; pfam03982"
                     /db_xref="CDD:112781"
     Site            order(133,136,159..162,210..212)
                     /site_type="active"
                     /note="putative acyl-acceptor binding pocket [active]"
                     /db_xref="CDD:153249"
     CDS             1..358
                     /gene="DGAT2"
                     /gene_synonym="ARAT; GS1999FULL; HMFN1045"
                     /coded_by="XM_054370204.1:55..1131"
                     /db_xref="GeneID:84649"
                     /db_xref="HGNC:HGNC:16940"
                     /db_xref="MIM:606983"
ORIGIN      
        1 mdsvkgspvt gtgssilsal qdlfsvtwln rskvekqlqv isvlqwvlsf lvlgvacsai
       61 lmyifctdcw liavlyftwl vfdwntpkkg grrsqwvrnw avwryfrdyf piqlvkthnl
      121 lttrnyifgy hphgimglga fcnfsteate vskkfpgirp ylatlagnfr mpvlreylms
      181 ggicpvsrdt idyllskngs gnaiiivvgg aaeslssmpg knavtlrnrk gfvklalrhg
      241 adlvpiysfg enevykqvif eegswgrwvq kkfqkyigfa pcifhgrglf ssdtwglvpy
      301 skpittvvge pitipklehp tqqdidlyht mymealvklf dkhktkfglp etevlevn
//
LOCUS       XP_054226180             297 aa            linear   PRI 05-AUG-2025
DEFINITION  diacylglycerol O-acyltransferase 2 isoform X2 [Homo sapiens].
ACCESSION   XP_054226180
VERSION     XP_054226180.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370205.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..297
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..297
                     /product="diacylglycerol O-acyltransferase 2 isoform X2"
                     /calculated_mol_wt=33873
     Region          1..297
                     /region_name="DAGAT"
                     /note="Diacylglycerol acyltransferase; pfam03982"
                     /db_xref="CDD:112781"
     Site            order(72,75,98..101,149..151)
                     /site_type="active"
                     /note="putative acyl-acceptor binding pocket [active]"
                     /db_xref="CDD:153249"
     CDS             1..297
                     /gene="DGAT2"
                     /gene_synonym="ARAT; GS1999FULL; HMFN1045"
                     /coded_by="XM_054370205.1:244..1137"
                     /db_xref="GeneID:84649"
                     /db_xref="HGNC:HGNC:16940"
                     /db_xref="MIM:606983"
ORIGIN      
        1 myifctdcwl iavlyftwlv fdwntpkkgg rrsqwvrnwa vwryfrdyfp iqlvkthnll
       61 ttrnyifgyh phgimglgaf cnfsteatev skkfpgirpy latlagnfrm pvlreylmsg
      121 gicpvsrdti dyllskngsg naiiivvgga aeslssmpgk navtlrnrkg fvklalrhga
      181 dlvpiysfge nevykqvife egswgrwvqk kfqkyigfap cifhgrglfs sdtwglvpys
      241 kpittvvgep itipklehpt qqdidlyhtm ymealvklfd khktkfglpe tevlevn
//
LOCUS       XP_054226181             602 aa            linear   PRI 05-AUG-2025
DEFINITION  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform
            X1 [Homo sapiens].
ACCESSION   XP_054226181
VERSION     XP_054226181.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370206.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..602
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..602
                     /product="1-aminocyclopropane-1-carboxylate synthase-like
                     protein 1 isoform X1"
                     /calculated_mol_wt=68939
     Region          154..600
                     /region_name="PLN02450"
                     /note="1-aminocyclopropane-1-carboxylate synthase"
                     /db_xref="CDD:178069"
     CDS             1..602
                     /gene="ACCS"
                     /gene_synonym="ACS; PHACS"
                     /coded_by="XM_054370206.1:877..2685"
                     /db_xref="GeneID:84680"
                     /db_xref="HGNC:HGNC:23989"
                     /db_xref="MIM:608405"
ORIGIN      
        1 mrklnwlrev keftpagrsr ppspwcphlv ssglkrqale lclgclhlwr fpflpslssy
       61 ppsasehhii ssyplhhktp rtprqysalt qeiltwhlvi emftlpqkdf rapttclgpt
      121 cmqdlgsshg edlegecsrk ldqklpelrg vgdpamissd tsylssrgrm ikwfwdsaee
      181 gyrtyhmdey dedknpsgii nlgtsenklc fdllswrlsq rdmqrvepsl lqyadwrghl
      241 flreevakfl sfyckspvpl rpenvvvlng gaslfsalat vlceageafl iptpyygait
      301 qhvclygnir layvyldsev tgldtrpfql tveklemalr eahsegvkvk glilispqnp
      361 lgdvyspeel qeylvfakrh rlhvivdevy mlsvfeksvg yrsvlslerl pdpqrthvmw
      421 atskdfgmsg lrfgtlyten qdvatavasl cryhglsglv qyqmaqllrd rdwinqvylp
      481 enharlkaah tyvseelral gipflsrgag ffiwvdlrky llkgtfeeem llwrrfldnk
      541 vllsfgkafe ckepgwfrfv fsdqvhrlcl gmqrvqqvla gksqvaedpr psqsqepsdq
      601 rr
//
LOCUS       XP_054226182             576 aa            linear   PRI 05-AUG-2025
DEFINITION  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform
            X2 [Homo sapiens].
ACCESSION   XP_054226182
VERSION     XP_054226182.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370207.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..576
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..576
                     /product="1-aminocyclopropane-1-carboxylate synthase-like
                     protein 1 isoform X2"
                     /calculated_mol_wt=65109
     Region          154..>518
                     /region_name="PLN02450"
                     /note="1-aminocyclopropane-1-carboxylate synthase"
                     /db_xref="CDD:178069"
     CDS             1..576
                     /gene="ACCS"
                     /gene_synonym="ACS; PHACS"
                     /coded_by="XM_054370207.1:877..2607"
                     /db_xref="GeneID:84680"
                     /db_xref="HGNC:HGNC:23989"
                     /db_xref="MIM:608405"
ORIGIN      
        1 mrklnwlrev keftpagrsr ppspwcphlv ssglkrqale lclgclhlwr fpflpslssy
       61 ppsasehhii ssyplhhktp rtprqysalt qeiltwhlvi emftlpqkdf rapttclgpt
      121 cmqdlgsshg edlegecsrk ldqklpelrg vgdpamissd tsylssrgrm ikwfwdsaee
      181 gyrtyhmdey dedknpsgii nlgtsenklc fdllswrlsq rdmqrvepsl lqyadwrghl
      241 flreevakfl sfyckspvpl rpenvvvlng gaslfsalat vlceageafl iptpyygait
      301 qhvclygnir layvyldsev tgldtrpfql tveklemalr eahsegvkvk glilispqnp
      361 lgdvyspeel qeylvfakrh rlhvivdevy mlsvfeksvg yrsvlslerl pdpqrthvmw
      421 atskdfgmsg lrfgtlyten qdvatavasl cryhglsglv qyqmaqllrd rdwinqvylp
      481 enharlkaah tyvseelral gipflsrgag ffiwvdlrkg crgssrclqa npkwqktpvp
      541 lrarsqvtna gelvivswpe gpaatvdlgr sgaaed
//
LOCUS       XP_054226183             475 aa            linear   PRI 05-AUG-2025
DEFINITION  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform
            X3 [Homo sapiens].
ACCESSION   XP_054226183
VERSION     XP_054226183.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370208.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..475
                     /product="1-aminocyclopropane-1-carboxylate synthase-like
                     protein 1 isoform X3"
                     /calculated_mol_wt=53378
     Region          53..>417
                     /region_name="PLN02450"
                     /note="1-aminocyclopropane-1-carboxylate synthase"
                     /db_xref="CDD:178069"
     CDS             1..475
                     /gene="ACCS"
                     /gene_synonym="ACS; PHACS"
                     /coded_by="XM_054370208.1:433..1860"
                     /db_xref="GeneID:84680"
                     /db_xref="HGNC:HGNC:23989"
                     /db_xref="MIM:608405"
ORIGIN      
        1 mftlpqkdfr apttclgptc mqdlgsshge dlegecsrkl dqklpelrgv gdpamissdt
       61 sylssrgrmi kwfwdsaeeg yrtyhmdeyd edknpsgiin lgtsenklcf dllswrlsqr
      121 dmqrvepsll qyadwrghlf lreevakfls fyckspvplr penvvvlngg aslfsalatv
      181 lceageafli ptpyygaitq hvclygnirl ayvyldsevt gldtrpfqlt veklemalre
      241 ahsegvkvkg lilispqnpl gdvyspeelq eylvfakrhr lhvivdevym lsvfeksvgy
      301 rsvlslerlp dpqrthvmwa tskdfgmsgl rfgtlytenq dvatavaslc ryhglsglvq
      361 yqmaqllrdr dwinqvylpe nharlkaaht yvseelralg ipflsrgagf fiwvdlrkgc
      421 rgssrclqan pkwqktpvpl rarsqvtnag elvivswpeg paatvdlgrs gaaed
//
LOCUS       XP_054226184             475 aa            linear   PRI 05-AUG-2025
DEFINITION  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform
            X3 [Homo sapiens].
ACCESSION   XP_054226184
VERSION     XP_054226184.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370209.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..475
                     /product="1-aminocyclopropane-1-carboxylate synthase-like
                     protein 1 isoform X3"
                     /calculated_mol_wt=53378
     Region          53..>417
                     /region_name="PLN02450"
                     /note="1-aminocyclopropane-1-carboxylate synthase"
                     /db_xref="CDD:178069"
     CDS             1..475
                     /gene="ACCS"
                     /gene_synonym="ACS; PHACS"
                     /coded_by="XM_054370209.1:54..1481"
                     /db_xref="GeneID:84680"
                     /db_xref="HGNC:HGNC:23989"
                     /db_xref="MIM:608405"
ORIGIN      
        1 mftlpqkdfr apttclgptc mqdlgsshge dlegecsrkl dqklpelrgv gdpamissdt
       61 sylssrgrmi kwfwdsaeeg yrtyhmdeyd edknpsgiin lgtsenklcf dllswrlsqr
      121 dmqrvepsll qyadwrghlf lreevakfls fyckspvplr penvvvlngg aslfsalatv
      181 lceageafli ptpyygaitq hvclygnirl ayvyldsevt gldtrpfqlt veklemalre
      241 ahsegvkvkg lilispqnpl gdvyspeelq eylvfakrhr lhvivdevym lsvfeksvgy
      301 rsvlslerlp dpqrthvmwa tskdfgmsgl rfgtlytenq dvatavaslc ryhglsglvq
      361 yqmaqllrdr dwinqvylpe nharlkaaht yvseelralg ipflsrgagf fiwvdlrkgc
      421 rgssrclqan pkwqktpvpl rarsqvtnag elvivswpeg paatvdlgrs gaaed
//
LOCUS       XP_054226185             380 aa            linear   PRI 05-AUG-2025
DEFINITION  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform
            X4 [Homo sapiens].
ACCESSION   XP_054226185
VERSION     XP_054226185.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370210.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..380
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..380
                     /product="1-aminocyclopropane-1-carboxylate synthase-like
                     protein 1 isoform X4"
                     /calculated_mol_wt=43420
     Region          6..355
                     /region_name="AAT_like"
                     /note="Aspartate aminotransferase family. This family
                     belongs to pyridoxal phosphate (PLP)-dependent aspartate
                     aminotransferase superfamily (fold I). Pyridoxal phosphate
                     combines with an alpha-amino acid to form a compound
                     called a Schiff base or aldimine...; cd00609"
                     /db_xref="CDD:99734"
     Site            order(48..50,74,137,168,199,201..202,210)
                     /site_type="other"
                     /note="pyridoxal 5'-phosphate binding site [chemical
                     binding]"
                     /db_xref="CDD:99734"
     Site            order(51,84,161,208..210,238,241)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:99734"
     Site            202
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:99734"
     CDS             1..380
                     /gene="ACCS"
                     /gene_synonym="ACS; PHACS"
                     /coded_by="XM_054370210.1:300..1442"
                     /db_xref="GeneID:84680"
                     /db_xref="HGNC:HGNC:23989"
                     /db_xref="MIM:608405"
ORIGIN      
        1 mqrvepsllq yadwrghlfl reevakflsf yckspvplrp envvvlngga slfsalatvl
       61 ceageaflip tpyygaitqh vclygnirla yvyldsevtg ldtrpfqltv eklemalrea
      121 hsegvkvkgl ilispqnplg dvyspeelqe ylvfakrhrl hvivdevyml svfeksvgyr
      181 svlslerlpd pqrthvmwat skdfgmsglr fgtlytenqd vatavaslcr yhglsglvqy
      241 qmaqllrdrd winqvylpen harlkaahty vseelralgi pflsrgagff iwvdlrkyll
      301 kgtfeeemll wrrfldnkvl lsfgkafeck epgwfrfvfs dqvhrlclgm qrvqqvlagk
      361 sqvaedprps qsqepsdqrr
//
LOCUS       XP_054226186             371 aa            linear   PRI 05-AUG-2025
DEFINITION  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform
            X5 [Homo sapiens].
ACCESSION   XP_054226186
VERSION     XP_054226186.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370211.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..371
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..371
                     /product="1-aminocyclopropane-1-carboxylate synthase-like
                     protein 1 isoform X5"
                     /calculated_mol_wt=42283
     Region          9..369
                     /region_name="PLN02450"
                     /note="1-aminocyclopropane-1-carboxylate synthase"
                     /db_xref="CDD:178069"
     CDS             1..371
                     /gene="ACCS"
                     /gene_synonym="ACS; PHACS"
                     /coded_by="XM_054370211.1:62..1177"
                     /db_xref="GeneID:84680"
                     /db_xref="HGNC:HGNC:23989"
                     /db_xref="MIM:608405"
ORIGIN      
        1 msmmrtrtpv lreevakfls fyckspvplr penvvvlngg aslfsalatv lceageafli
       61 ptpyygaitq hvclygnirl ayvyldsevt gldtrpfqlt veklemalre ahsegvkvkg
      121 lilispqnpl gdvyspeelq eylvfakrhr lhvivdevym lsvfeksvgy rsvlslerlp
      181 dpqrthvmwa tskdfgmsgl rfgtlytenq dvatavaslc ryhglsglvq yqmaqllrdr
      241 dwinqvylpe nharlkaaht yvseelralg ipflsrgagf fiwvdlrkyl lkgtfeeeml
      301 lwrrfldnkv llsfgkafec kepgwfrfvf sdqvhrlclg mqrvqqvlag ksqvaedprp
      361 sqsqepsdqr r
//
LOCUS       XP_054226187             326 aa            linear   PRI 05-AUG-2025
DEFINITION  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform
            X6 [Homo sapiens].
ACCESSION   XP_054226187
VERSION     XP_054226187.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370212.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..326
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..326
                     /product="1-aminocyclopropane-1-carboxylate synthase-like
                     protein 1 isoform X6"
                     /calculated_mol_wt=37092
     Region          154..>296
                     /region_name="PLN02450"
                     /note="1-aminocyclopropane-1-carboxylate synthase"
                     /db_xref="CDD:178069"
     CDS             1..326
                     /gene="ACCS"
                     /gene_synonym="ACS; PHACS"
                     /coded_by="XM_054370212.1:877..1857"
                     /db_xref="GeneID:84680"
                     /db_xref="HGNC:HGNC:23989"
                     /db_xref="MIM:608405"
ORIGIN      
        1 mrklnwlrev keftpagrsr ppspwcphlv ssglkrqale lclgclhlwr fpflpslssy
       61 ppsasehhii ssyplhhktp rtprqysalt qeiltwhlvi emftlpqkdf rapttclgpt
      121 cmqdlgsshg edlegecsrk ldqklpelrg vgdpamissd tsylssrgrm ikwfwdsaee
      181 gyrtyhmdey dedknpsgii nlgtsenklc fdllswrlsq rdmqrvepsl lqyadwrghl
      241 flreevakfl sfyckspvpl rpenvvvlng gaslfsalat vlceageafl iptpyygait
      301 qhvclygnir layvyldsew lqsssl
//
LOCUS       XP_054226188             319 aa            linear   PRI 05-AUG-2025
DEFINITION  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform
            X7 [Homo sapiens].
ACCESSION   XP_054226188
VERSION     XP_054226188.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370213.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..319
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..319
                     /product="1-aminocyclopropane-1-carboxylate synthase-like
                     protein 1 isoform X7"
                     /calculated_mol_wt=36686
     Region          <45..317
                     /region_name="PLN02450"
                     /note="1-aminocyclopropane-1-carboxylate synthase"
                     /db_xref="CDD:178069"
     CDS             1..319
                     /gene="ACCS"
                     /gene_synonym="ACS; PHACS"
                     /coded_by="XM_054370213.1:174..1133"
                     /db_xref="GeneID:84680"
                     /db_xref="HGNC:HGNC:23989"
                     /db_xref="MIM:608405"
ORIGIN      
        1 mvvprssllw prccvrpghv clygnirlay vyldsevtgl dtrpfqltve klemalreah
       61 segvkvkgli lispqnplgd vyspeelqey lvfakrhrlh vivdevymls vfeksvgyrs
      121 vlslerlpdp qrthvmwats kdfgmsglrf gtlytenqdv atavaslcry hglsglvqyq
      181 maqllrdrdw inqvylpenh arlkaahtyv seelralgip flsrgagffi wvdlrkyllk
      241 gtfeeemllw rrfldnkvll sfgkafecke pgwfrfvfsd qvhrlclgmq rvqqvlagks
      301 qvaedprpsq sqepsdqrr
//
LOCUS       XP_054226189             319 aa            linear   PRI 05-AUG-2025
DEFINITION  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform
            X7 [Homo sapiens].
ACCESSION   XP_054226189
VERSION     XP_054226189.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370214.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..319
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..319
                     /product="1-aminocyclopropane-1-carboxylate synthase-like
                     protein 1 isoform X7"
                     /calculated_mol_wt=36686
     Region          <45..317
                     /region_name="PLN02450"
                     /note="1-aminocyclopropane-1-carboxylate synthase"
                     /db_xref="CDD:178069"
     CDS             1..319
                     /gene="ACCS"
                     /gene_synonym="ACS; PHACS"
                     /coded_by="XM_054370214.1:108..1067"
                     /db_xref="GeneID:84680"
                     /db_xref="HGNC:HGNC:23989"
                     /db_xref="MIM:608405"
ORIGIN      
        1 mvvprssllw prccvrpghv clygnirlay vyldsevtgl dtrpfqltve klemalreah
       61 segvkvkgli lispqnplgd vyspeelqey lvfakrhrlh vivdevymls vfeksvgyrs
      121 vlslerlpdp qrthvmwats kdfgmsglrf gtlytenqdv atavaslcry hglsglvqyq
      181 maqllrdrdw inqvylpenh arlkaahtyv seelralgip flsrgagffi wvdlrkyllk
      241 gtfeeemllw rrfldnkvll sfgkafecke pgwfrfvfsd qvhrlclgmq rvqqvlagks
      301 qvaedprpsq sqepsdqrr
//
LOCUS       XP_054226190             303 aa            linear   PRI 05-AUG-2025
DEFINITION  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform
            X8 [Homo sapiens].
ACCESSION   XP_054226190
VERSION     XP_054226190.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370215.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..303
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..303
                     /product="1-aminocyclopropane-1-carboxylate synthase-like
                     protein 1 isoform X8"
                     /calculated_mol_wt=34328
     Region          154..>286
                     /region_name="PLN02450"
                     /note="1-aminocyclopropane-1-carboxylate synthase"
                     /db_xref="CDD:178069"
     CDS             1..303
                     /gene="ACCS"
                     /gene_synonym="ACS; PHACS"
                     /coded_by="XM_054370215.1:877..1788"
                     /db_xref="GeneID:84680"
                     /db_xref="HGNC:HGNC:23989"
                     /db_xref="MIM:608405"
ORIGIN      
        1 mrklnwlrev keftpagrsr ppspwcphlv ssglkrqale lclgclhlwr fpflpslssy
       61 ppsasehhii ssyplhhktp rtprqysalt qeiltwhlvi emftlpqkdf rapttclgpt
      121 cmqdlgsshg edlegecsrk ldqklpelrg vgdpamissd tsylssrgrm ikwfwdsaee
      181 gyrtyhmdey dedknpsgii nlgtsenklc fdllswrlsq rdmqrvepsl lqyadwrghl
      241 flreevakfl sfyckspvpl rpenvvvlng gaslfsalat vlceagarvs lwqhpaglcl
      301 pgq
//
LOCUS       XP_054226191             303 aa            linear   PRI 05-AUG-2025
DEFINITION  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform
            X8 [Homo sapiens].
ACCESSION   XP_054226191
VERSION     XP_054226191.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370216.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..303
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..303
                     /product="1-aminocyclopropane-1-carboxylate synthase-like
                     protein 1 isoform X8"
                     /calculated_mol_wt=34328
     Region          154..>286
                     /region_name="PLN02450"
                     /note="1-aminocyclopropane-1-carboxylate synthase"
                     /db_xref="CDD:178069"
     CDS             1..303
                     /gene="ACCS"
                     /gene_synonym="ACS; PHACS"
                     /coded_by="XM_054370216.1:877..1788"
                     /db_xref="GeneID:84680"
                     /db_xref="HGNC:HGNC:23989"
                     /db_xref="MIM:608405"
ORIGIN      
        1 mrklnwlrev keftpagrsr ppspwcphlv ssglkrqale lclgclhlwr fpflpslssy
       61 ppsasehhii ssyplhhktp rtprqysalt qeiltwhlvi emftlpqkdf rapttclgpt
      121 cmqdlgsshg edlegecsrk ldqklpelrg vgdpamissd tsylssrgrm ikwfwdsaee
      181 gyrtyhmdey dedknpsgii nlgtsenklc fdllswrlsq rdmqrvepsl lqyadwrghl
      241 flreevakfl sfyckspvpl rpenvvvlng gaslfsalat vlceagarvs lwqhpaglcl
      301 pgq
//
LOCUS       XP_054226192             586 aa            linear   PRI 05-AUG-2025
DEFINITION  BUD13 homolog isoform X1 [Homo sapiens].
ACCESSION   XP_054226192
VERSION     XP_054226192.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370217.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..586
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..586
                     /product="BUD13 homolog isoform X1"
                     /calculated_mol_wt=67110
     Region          <103..369
                     /region_name="MSCRAMM_ClfB"
                     /note="MSCRAMM family adhesin clumping factor ClfB;
                     NF033845"
                     /db_xref="CDD:468203"
     Region          427..569
                     /region_name="Bud13"
                     /note="Pre-mRNA-splicing factor of RES complex; pfam09736"
                     /db_xref="CDD:462867"
     CDS             1..586
                     /gene="BUD13"
                     /gene_synonym="ACHPS; Cwc26; fSAP71"
                     /coded_by="XM_054370217.1:958..2718"
                     /db_xref="GeneID:84811"
                     /db_xref="HGNC:HGNC:28199"
                     /db_xref="MIM:620691"
ORIGIN      
        1 mkaeigldlc cqkprmrivd ddvswtaist tklekeeeed dgdlpvvaef vderpeevkq
       61 meafrssakw kllgghnedl psnrhfrhdt pdssprrvrh gtpdpsprkd rhdtpdpspr
      121 rarhdtpdps plrgarhdsd tspprrirhd ssdtspprra rhdspdpspp rrpqhnssga
      181 sprrvrhdsp dpspprrarh gssdissprr vhnnspdtsr rtlgssdtqq lrrarhdspd
      241 lapnvtyslp rtksgkaper assktsphwk esgashlsfp knskyeydpd ispprkkqak
      301 shfgdkkqld skgdcqkatd sdlssprhkq spghqdsdsd lspprnrprh rssdsdlspp
      361 rrrqrtkssd sdlspprrsq ppgkkaahmy sgaktglvlt diqreqqelk eqdqetmafe
      421 aefqyaetvf rdksgrkrnl klerleqrrk aekdserdel yaqwgkglaq srqqqqnved
      481 amkemqkpla ryiddedldr mlreqeregd pmanfikknk akenknkkvr prysgpappp
      541 nrfniwpgyr wdgvdrsngf eqkrfarlas kkaveelayk wsvedm
//
LOCUS       XP_054226193             382 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 25 isoform X1 [Homo sapiens].
ACCESSION   XP_054226193
VERSION     XP_054226193.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370218.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..382
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..382
                     /product="transmembrane protein 25 isoform X1"
                     /calculated_mol_wt=40735
     Region          27..118
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          48..52
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          62..66
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          91..94
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          104..109
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     CDS             1..382
                     /gene="TMEM25"
                     /coded_by="XM_054370218.1:71..1219"
                     /db_xref="GeneID:84866"
                     /db_xref="HGNC:HGNC:25890"
                     /db_xref="MIM:613934"
ORIGIN      
        1 malppgpaal rhtllllpal lssgwgelep qidgqtwaer alrenerhaf tcrvaggpgt
       61 prlawyldgq lqeastsrll svggeafsgg tstftvtahr aqhelncslq dprsgrsana
      121 svilnvqfkp eiaqvgakyq eaqgpgllvv lfalvranpp anvtwidqdg pvtvntsdfl
      181 vldaqnypwl tnhtvqlqlr slahnlsvva tndvgvtsas lpapgllatr vevpllgivv
      241 aaglalgtlv gfstlvaclv crkekktkgp srhpslissd snnlklnnvr lprenmslps
      301 nlqlndltpd sravkpadrq maqnnsrpel ldpepggllt sqacllhhgt paltnpwlph
      361 qqegalpggw spqahnstvw kl
//
LOCUS       XP_054226194             382 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 25 isoform X1 [Homo sapiens].
ACCESSION   XP_054226194
VERSION     XP_054226194.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370219.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..382
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..382
                     /product="transmembrane protein 25 isoform X1"
                     /calculated_mol_wt=40735
     Region          27..118
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          48..52
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          62..66
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          91..94
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          104..109
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     CDS             1..382
                     /gene="TMEM25"
                     /coded_by="XM_054370219.1:68..1216"
                     /db_xref="GeneID:84866"
                     /db_xref="HGNC:HGNC:25890"
                     /db_xref="MIM:613934"
ORIGIN      
        1 malppgpaal rhtllllpal lssgwgelep qidgqtwaer alrenerhaf tcrvaggpgt
       61 prlawyldgq lqeastsrll svggeafsgg tstftvtahr aqhelncslq dprsgrsana
      121 svilnvqfkp eiaqvgakyq eaqgpgllvv lfalvranpp anvtwidqdg pvtvntsdfl
      181 vldaqnypwl tnhtvqlqlr slahnlsvva tndvgvtsas lpapgllatr vevpllgivv
      241 aaglalgtlv gfstlvaclv crkekktkgp srhpslissd snnlklnnvr lprenmslps
      301 nlqlndltpd sravkpadrq maqnnsrpel ldpepggllt sqacllhhgt paltnpwlph
      361 qqegalpggw spqahnstvw kl
//
LOCUS       XP_054226195             366 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 25 isoform X2 [Homo sapiens].
ACCESSION   XP_054226195
VERSION     XP_054226195.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370220.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..366
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..366
                     /product="transmembrane protein 25 isoform X2"
                     /calculated_mol_wt=39154
     Region          27..118
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          48..52
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          62..66
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          91..94
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          104..109
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     CDS             1..366
                     /gene="TMEM25"
                     /coded_by="XM_054370220.1:68..1168"
                     /db_xref="GeneID:84866"
                     /db_xref="HGNC:HGNC:25890"
                     /db_xref="MIM:613934"
ORIGIN      
        1 malppgpaal rhtllllpal lssgwgelep qidgqtwaer alrenerhaf tcrvaggpgt
       61 prlawyldgq lqeastsrll svggeafsgg tstftvtahr aqhelncslq dprsgrsana
      121 svilnvqfkp eiaqvgakyq eaqgpgllvv lfalvranpp anvtwidqdg pvtvntsdfl
      181 vldaqnypwl tnhtvqlqlr slahnlsvva tndvgvtsas lpapgllatr vevpllgivv
      241 aaglalgtlv gfstlvaclv crkekktkgp srhpslissd snnlklnnvr lprenmslps
      301 nlqlndltpd sravkpadrq maqnnsrpel ldpepggllt sqgfirlpvl gyiyrvssvs
      361 sdeiwl
//
LOCUS       XP_054226196             365 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 25 isoform X3 [Homo sapiens].
ACCESSION   XP_054226196
VERSION     XP_054226196.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370221.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..365
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..365
                     /product="transmembrane protein 25 isoform X3"
                     /calculated_mol_wt=39083
     Region          27..118
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          48..52
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          62..66
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          91..94
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          104..109
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     CDS             1..365
                     /gene="TMEM25"
                     /coded_by="XM_054370221.1:71..1168"
                     /db_xref="GeneID:84866"
                     /db_xref="HGNC:HGNC:25890"
                     /db_xref="MIM:613934"
ORIGIN      
        1 malppgpaal rhtllllpal lssgwgelep qidgqtwaer alrenerhaf tcrvaggpgt
       61 prlawyldgq lqeastsrll svggeafsgg tstftvtahr aqhelncslq dprsgrsana
      121 svilnvqfkp eiaqvgakyq eaqgpgllvv lfalvranpp anvtwidqdg pvtvntsdfl
      181 vldaqnypwl tnhtvqlqlr slahnlsvva tndvgvtsas lpapgllatr vevpllgivv
      241 aaglalgtlv gfstlvaclv crkekktkgp srhpslissd snnlklnnvr lprenmslps
      301 nlqlndltpd srvkpadrqm aqnnsrpell dpepggllts qgfirlpvlg yiyrvssvss
      361 deiwl
//
LOCUS       XP_054226197             365 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 25 isoform X3 [Homo sapiens].
ACCESSION   XP_054226197
VERSION     XP_054226197.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370222.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..365
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..365
                     /product="transmembrane protein 25 isoform X3"
                     /calculated_mol_wt=39083
     Region          27..118
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          48..52
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          62..66
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          91..94
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          104..109
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     CDS             1..365
                     /gene="TMEM25"
                     /coded_by="XM_054370222.1:570..1667"
                     /db_xref="GeneID:84866"
                     /db_xref="HGNC:HGNC:25890"
                     /db_xref="MIM:613934"
ORIGIN      
        1 malppgpaal rhtllllpal lssgwgelep qidgqtwaer alrenerhaf tcrvaggpgt
       61 prlawyldgq lqeastsrll svggeafsgg tstftvtahr aqhelncslq dprsgrsana
      121 svilnvqfkp eiaqvgakyq eaqgpgllvv lfalvranpp anvtwidqdg pvtvntsdfl
      181 vldaqnypwl tnhtvqlqlr slahnlsvva tndvgvtsas lpapgllatr vevpllgivv
      241 aaglalgtlv gfstlvaclv crkekktkgp srhpslissd snnlklnnvr lprenmslps
      301 nlqlndltpd srvkpadrqm aqnnsrpell dpepggllts qgfirlpvlg yiyrvssvss
      361 deiwl
//
LOCUS       XP_054226198             365 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 25 isoform X3 [Homo sapiens].
ACCESSION   XP_054226198
VERSION     XP_054226198.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370223.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..365
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..365
                     /product="transmembrane protein 25 isoform X3"
                     /calculated_mol_wt=39083
     Region          27..118
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          48..52
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          62..66
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          91..94
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          104..109
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     CDS             1..365
                     /gene="TMEM25"
                     /coded_by="XM_054370223.1:68..1165"
                     /db_xref="GeneID:84866"
                     /db_xref="HGNC:HGNC:25890"
                     /db_xref="MIM:613934"
ORIGIN      
        1 malppgpaal rhtllllpal lssgwgelep qidgqtwaer alrenerhaf tcrvaggpgt
       61 prlawyldgq lqeastsrll svggeafsgg tstftvtahr aqhelncslq dprsgrsana
      121 svilnvqfkp eiaqvgakyq eaqgpgllvv lfalvranpp anvtwidqdg pvtvntsdfl
      181 vldaqnypwl tnhtvqlqlr slahnlsvva tndvgvtsas lpapgllatr vevpllgivv
      241 aaglalgtlv gfstlvaclv crkekktkgp srhpslissd snnlklnnvr lprenmslps
      301 nlqlndltpd srvkpadrqm aqnnsrpell dpepggllts qgfirlpvlg yiyrvssvss
      361 deiwl
//
LOCUS       XP_054226199             351 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 25 isoform X4 [Homo sapiens].
ACCESSION   XP_054226199
VERSION     XP_054226199.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370224.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..351
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..351
                     /product="transmembrane protein 25 isoform X4"
                     /calculated_mol_wt=37443
     Region          27..118
                     /region_name="C2-set_2"
                     /note="CD80-like C2-set immunoglobulin domain; pfam08205"
                     /db_xref="CDD:400489"
     Region          48..52
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409502"
     Region          62..66
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409502"
     Region          91..94
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409502"
     Region          104..109
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409502"
     CDS             1..351
                     /gene="TMEM25"
                     /coded_by="XM_054370224.1:559..1614"
                     /db_xref="GeneID:84866"
                     /db_xref="HGNC:HGNC:25890"
                     /db_xref="MIM:613934"
ORIGIN      
        1 malppgpaal rhtllllpal lssgwgelep qidgqtwaer alrenerhaf tcrvaggpgt
       61 prlawyldgq lqeastsrll svggeafsgg tstftvtahr aqhelncslq dprsgrsana
      121 svilnvqfkp eiaqvgakyq eaqgpgllvv lfalvranpp anvtwidqdg pvtvntsdfl
      181 vldaqnypwl tnhtvqlqlr slahnlsvva tndvgvtsas lpapgllatr vevpllgivv
      241 aaglalgtlv gfstlvaclv crkekktkgp srhpslissd snnlklnnvr lprenmslps
      301 nlqlndltpd sravkpadrq maqnnsrpel ldpepggllt sqgrrnqdkd a
//
LOCUS       XP_054226200             351 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 25 isoform X4 [Homo sapiens].
ACCESSION   XP_054226200
VERSION     XP_054226200.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370225.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..351
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..351
                     /product="transmembrane protein 25 isoform X4"
                     /calculated_mol_wt=37443
     Region          27..118
                     /region_name="C2-set_2"
                     /note="CD80-like C2-set immunoglobulin domain; pfam08205"
                     /db_xref="CDD:400489"
     Region          48..52
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409502"
     Region          62..66
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409502"
     Region          91..94
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409502"
     Region          104..109
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409502"
     CDS             1..351
                     /gene="TMEM25"
                     /coded_by="XM_054370225.1:68..1123"
                     /db_xref="GeneID:84866"
                     /db_xref="HGNC:HGNC:25890"
                     /db_xref="MIM:613934"
ORIGIN      
        1 malppgpaal rhtllllpal lssgwgelep qidgqtwaer alrenerhaf tcrvaggpgt
       61 prlawyldgq lqeastsrll svggeafsgg tstftvtahr aqhelncslq dprsgrsana
      121 svilnvqfkp eiaqvgakyq eaqgpgllvv lfalvranpp anvtwidqdg pvtvntsdfl
      181 vldaqnypwl tnhtvqlqlr slahnlsvva tndvgvtsas lpapgllatr vevpllgivv
      241 aaglalgtlv gfstlvaclv crkekktkgp srhpslissd snnlklnnvr lprenmslps
      301 nlqlndltpd sravkpadrq maqnnsrpel ldpepggllt sqgrrnqdkd a
//
LOCUS       XP_054226201             350 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 25 isoform X5 [Homo sapiens].
ACCESSION   XP_054226201
VERSION     XP_054226201.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370226.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..350
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..350
                     /product="transmembrane protein 25 isoform X5"
                     /calculated_mol_wt=37372
     Region          27..118
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          48..52
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          62..66
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          91..94
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          104..109
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     CDS             1..350
                     /gene="TMEM25"
                     /coded_by="XM_054370226.1:71..1123"
                     /db_xref="GeneID:84866"
                     /db_xref="HGNC:HGNC:25890"
                     /db_xref="MIM:613934"
ORIGIN      
        1 malppgpaal rhtllllpal lssgwgelep qidgqtwaer alrenerhaf tcrvaggpgt
       61 prlawyldgq lqeastsrll svggeafsgg tstftvtahr aqhelncslq dprsgrsana
      121 svilnvqfkp eiaqvgakyq eaqgpgllvv lfalvranpp anvtwidqdg pvtvntsdfl
      181 vldaqnypwl tnhtvqlqlr slahnlsvva tndvgvtsas lpapgllatr vevpllgivv
      241 aaglalgtlv gfstlvaclv crkekktkgp srhpslissd snnlklnnvr lprenmslps
      301 nlqlndltpd srvkpadrqm aqnnsrpell dpepggllts qgrrnqdkda
//
LOCUS       XP_054226202             338 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 25 isoform X6 [Homo sapiens].
ACCESSION   XP_054226202
VERSION     XP_054226202.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370227.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..338
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..338
                     /product="transmembrane protein 25 isoform X6"
                     /calculated_mol_wt=36244
     Region          27..118
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          48..52
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409502"
     Region          62..66
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409502"
     Region          91..94
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409502"
     Region          104..109
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409502"
     CDS             1..338
                     /gene="TMEM25"
                     /coded_by="XM_054370227.1:71..1087"
                     /db_xref="GeneID:84866"
                     /db_xref="HGNC:HGNC:25890"
                     /db_xref="MIM:613934"
ORIGIN      
        1 malppgpaal rhtllllpal lssgwgelep qidgqtwaer alrenerhaf tcrvaggpgt
       61 prlawyldgq lqeastsrll svggeafsgg tstftvtahr aqhelncslq dprsgrsana
      121 svilnvqfkp eiaqvgakyq eaqgpgllvv lfalvranpp anvtwidqdg pvtvntsdfl
      181 vldaqnypwl tnhtvqlqlr slahnlsvva tndvgvtsas lpapgpsrhp slissdsnnl
      241 klnnvrlpre nmslpsnlql ndltpdsrav kpadrqmaqn nsrpelldpe pgglltsqac
      301 llhhgtpalt npwlphqqeg alpggwspqa hnstvwkl
//
LOCUS       XP_054226203             338 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 25 isoform X6 [Homo sapiens].
ACCESSION   XP_054226203
VERSION     XP_054226203.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370228.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..338
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..338
                     /product="transmembrane protein 25 isoform X6"
                     /calculated_mol_wt=36244
     Region          27..118
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          48..52
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409502"
     Region          62..66
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409502"
     Region          91..94
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409502"
     Region          104..109
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409502"
     CDS             1..338
                     /gene="TMEM25"
                     /coded_by="XM_054370228.1:68..1084"
                     /db_xref="GeneID:84866"
                     /db_xref="HGNC:HGNC:25890"
                     /db_xref="MIM:613934"
ORIGIN      
        1 malppgpaal rhtllllpal lssgwgelep qidgqtwaer alrenerhaf tcrvaggpgt
       61 prlawyldgq lqeastsrll svggeafsgg tstftvtahr aqhelncslq dprsgrsana
      121 svilnvqfkp eiaqvgakyq eaqgpgllvv lfalvranpp anvtwidqdg pvtvntsdfl
      181 vldaqnypwl tnhtvqlqlr slahnlsvva tndvgvtsas lpapgpsrhp slissdsnnl
      241 klnnvrlpre nmslpsnlql ndltpdsrav kpadrqmaqn nsrpelldpe pgglltsqac
      301 llhhgtpalt npwlphqqeg alpggwspqa hnstvwkl
//
LOCUS       XP_054226204             338 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 25 isoform X6 [Homo sapiens].
ACCESSION   XP_054226204
VERSION     XP_054226204.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370229.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..338
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..338
                     /product="transmembrane protein 25 isoform X6"
                     /calculated_mol_wt=36244
     Region          27..118
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          48..52
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409502"
     Region          62..66
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409502"
     Region          91..94
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409502"
     Region          104..109
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409502"
     CDS             1..338
                     /gene="TMEM25"
                     /coded_by="XM_054370229.1:559..1575"
                     /db_xref="GeneID:84866"
                     /db_xref="HGNC:HGNC:25890"
                     /db_xref="MIM:613934"
ORIGIN      
        1 malppgpaal rhtllllpal lssgwgelep qidgqtwaer alrenerhaf tcrvaggpgt
       61 prlawyldgq lqeastsrll svggeafsgg tstftvtahr aqhelncslq dprsgrsana
      121 svilnvqfkp eiaqvgakyq eaqgpgllvv lfalvranpp anvtwidqdg pvtvntsdfl
      181 vldaqnypwl tnhtvqlqlr slahnlsvva tndvgvtsas lpapgpsrhp slissdsnnl
      241 klnnvrlpre nmslpsnlql ndltpdsrav kpadrqmaqn nsrpelldpe pgglltsqac
      301 llhhgtpalt npwlphqqeg alpggwspqa hnstvwkl
//
LOCUS       XP_054226205             337 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 25 isoform X7 [Homo sapiens].
ACCESSION   XP_054226205
VERSION     XP_054226205.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370230.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..337
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..337
                     /product="transmembrane protein 25 isoform X7"
                     /calculated_mol_wt=36173
     Region          27..118
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          48..52
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          62..66
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          91..94
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          104..109
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     CDS             1..337
                     /gene="TMEM25"
                     /coded_by="XM_054370230.1:71..1084"
                     /db_xref="GeneID:84866"
                     /db_xref="HGNC:HGNC:25890"
                     /db_xref="MIM:613934"
ORIGIN      
        1 malppgpaal rhtllllpal lssgwgelep qidgqtwaer alrenerhaf tcrvaggpgt
       61 prlawyldgq lqeastsrll svggeafsgg tstftvtahr aqhelncslq dprsgrsana
      121 svilnvqfkp eiaqvgakyq eaqgpgllvv lfalvranpp anvtwidqdg pvtvntsdfl
      181 vldaqnypwl tnhtvqlqlr slahnlsvva tndvgvtsas lpapgpsrhp slissdsnnl
      241 klnnvrlpre nmslpsnlql ndltpdsrvk padrqmaqnn srpelldpep gglltsqacl
      301 lhhgtpaltn pwlphqqega lpggwspqah nstvwkl
//
LOCUS       XP_054226206             322 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 25 isoform X8 [Homo sapiens].
ACCESSION   XP_054226206
VERSION     XP_054226206.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370231.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..322
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..322
                     /product="transmembrane protein 25 isoform X8"
                     /calculated_mol_wt=34662
     Region          27..118
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          48..52
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          62..66
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          91..94
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          104..109
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     CDS             1..322
                     /gene="TMEM25"
                     /coded_by="XM_054370231.1:606..1574"
                     /db_xref="GeneID:84866"
                     /db_xref="HGNC:HGNC:25890"
                     /db_xref="MIM:613934"
ORIGIN      
        1 malppgpaal rhtllllpal lssgwgelep qidgqtwaer alrenerhaf tcrvaggpgt
       61 prlawyldgq lqeastsrll svggeafsgg tstftvtahr aqhelncslq dprsgrsana
      121 svilnvqfkp eiaqvgakyq eaqgpgllvv lfalvranpp anvtwidqdg pvtvntsdfl
      181 vldaqnypwl tnhtvqlqlr slahnlsvva tndvgvtsas lpapgpsrhp slissdsnnl
      241 klnnvrlpre nmslpsnlql ndltpdsrav kpadrqmaqn nsrpelldpe pgglltsqgf
      301 irlpvlgyiy rvssvssdei wl
//
LOCUS       XP_054226207             321 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 25 isoform X9 [Homo sapiens].
ACCESSION   XP_054226207
VERSION     XP_054226207.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370232.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..321
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..321
                     /product="transmembrane protein 25 isoform X9"
                     /calculated_mol_wt=34591
     Region          27..118
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          48..52
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          62..66
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          91..94
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          104..109
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     CDS             1..321
                     /gene="TMEM25"
                     /coded_by="XM_054370232.1:71..1036"
                     /db_xref="GeneID:84866"
                     /db_xref="HGNC:HGNC:25890"
                     /db_xref="MIM:613934"
ORIGIN      
        1 malppgpaal rhtllllpal lssgwgelep qidgqtwaer alrenerhaf tcrvaggpgt
       61 prlawyldgq lqeastsrll svggeafsgg tstftvtahr aqhelncslq dprsgrsana
      121 svilnvqfkp eiaqvgakyq eaqgpgllvv lfalvranpp anvtwidqdg pvtvntsdfl
      181 vldaqnypwl tnhtvqlqlr slahnlsvva tndvgvtsas lpapgpsrhp slissdsnnl
      241 klnnvrlpre nmslpsnlql ndltpdsrvk padrqmaqnn srpelldpep gglltsqgfi
      301 rlpvlgyiyr vssvssdeiw l
//
LOCUS       XP_054226208             307 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 25 isoform X10 [Homo sapiens].
ACCESSION   XP_054226208
VERSION     XP_054226208.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370233.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..307
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..307
                     /product="transmembrane protein 25 isoform X10"
                     /calculated_mol_wt=32951
     Region          27..118
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          48..52
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          62..66
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          91..94
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          104..109
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     CDS             1..307
                     /gene="TMEM25"
                     /coded_by="XM_054370233.1:71..994"
                     /db_xref="GeneID:84866"
                     /db_xref="HGNC:HGNC:25890"
                     /db_xref="MIM:613934"
ORIGIN      
        1 malppgpaal rhtllllpal lssgwgelep qidgqtwaer alrenerhaf tcrvaggpgt
       61 prlawyldgq lqeastsrll svggeafsgg tstftvtahr aqhelncslq dprsgrsana
      121 svilnvqfkp eiaqvgakyq eaqgpgllvv lfalvranpp anvtwidqdg pvtvntsdfl
      181 vldaqnypwl tnhtvqlqlr slahnlsvva tndvgvtsas lpapgpsrhp slissdsnnl
      241 klnnvrlpre nmslpsnlql ndltpdsrav kpadrqmaqn nsrpelldpe pgglltsqgr
      301 rnqdkda
//
LOCUS       XP_054226209             307 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 25 isoform X10 [Homo sapiens].
ACCESSION   XP_054226209
VERSION     XP_054226209.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370234.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..307
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..307
                     /product="transmembrane protein 25 isoform X10"
                     /calculated_mol_wt=32951
     Region          27..118
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          48..52
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          62..66
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          91..94
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          104..109
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     CDS             1..307
                     /gene="TMEM25"
                     /coded_by="XM_054370234.1:606..1529"
                     /db_xref="GeneID:84866"
                     /db_xref="HGNC:HGNC:25890"
                     /db_xref="MIM:613934"
ORIGIN      
        1 malppgpaal rhtllllpal lssgwgelep qidgqtwaer alrenerhaf tcrvaggpgt
       61 prlawyldgq lqeastsrll svggeafsgg tstftvtahr aqhelncslq dprsgrsana
      121 svilnvqfkp eiaqvgakyq eaqgpgllvv lfalvranpp anvtwidqdg pvtvntsdfl
      181 vldaqnypwl tnhtvqlqlr slahnlsvva tndvgvtsas lpapgpsrhp slissdsnnl
      241 klnnvrlpre nmslpsnlql ndltpdsrav kpadrqmaqn nsrpelldpe pgglltsqgr
      301 rnqdkda
//
LOCUS       XP_054226210             307 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 25 isoform X10 [Homo sapiens].
ACCESSION   XP_054226210
VERSION     XP_054226210.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370235.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..307
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..307
                     /product="transmembrane protein 25 isoform X10"
                     /calculated_mol_wt=32951
     Region          27..118
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          48..52
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          62..66
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          91..94
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          104..109
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     CDS             1..307
                     /gene="TMEM25"
                     /coded_by="XM_054370235.1:68..991"
                     /db_xref="GeneID:84866"
                     /db_xref="HGNC:HGNC:25890"
                     /db_xref="MIM:613934"
ORIGIN      
        1 malppgpaal rhtllllpal lssgwgelep qidgqtwaer alrenerhaf tcrvaggpgt
       61 prlawyldgq lqeastsrll svggeafsgg tstftvtahr aqhelncslq dprsgrsana
      121 svilnvqfkp eiaqvgakyq eaqgpgllvv lfalvranpp anvtwidqdg pvtvntsdfl
      181 vldaqnypwl tnhtvqlqlr slahnlsvva tndvgvtsas lpapgpsrhp slissdsnnl
      241 klnnvrlpre nmslpsnlql ndltpdsrav kpadrqmaqn nsrpelldpe pgglltsqgr
      301 rnqdkda
//
LOCUS       XP_054226211             306 aa            linear   PRI 05-AUG-2025
DEFINITION  transmembrane protein 25 isoform X11 [Homo sapiens].
ACCESSION   XP_054226211
VERSION     XP_054226211.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370236.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..306
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..306
                     /product="transmembrane protein 25 isoform X11"
                     /calculated_mol_wt=32880
     Region          27..118
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          48..52
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          62..66
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          91..94
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          104..109
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     CDS             1..306
                     /gene="TMEM25"
                     /coded_by="XM_054370236.1:596..1516"
                     /db_xref="GeneID:84866"
                     /db_xref="HGNC:HGNC:25890"
                     /db_xref="MIM:613934"
ORIGIN      
        1 malppgpaal rhtllllpal lssgwgelep qidgqtwaer alrenerhaf tcrvaggpgt
       61 prlawyldgq lqeastsrll svggeafsgg tstftvtahr aqhelncslq dprsgrsana
      121 svilnvqfkp eiaqvgakyq eaqgpgllvv lfalvranpp anvtwidqdg pvtvntsdfl
      181 vldaqnypwl tnhtvqlqlr slahnlsvva tndvgvtsas lpapgpsrhp slissdsnnl
      241 klnnvrlpre nmslpsnlql ndltpdsrvk padrqmaqnn srpelldpep gglltsqgrr
      301 nqdkda
//
LOCUS       XP_054226212             719 aa            linear   PRI 05-AUG-2025
DEFINITION  tyrosine-protein phosphatase non-receptor type 5 isoform X1 [Homo
            sapiens].
ACCESSION   XP_054226212
VERSION     XP_054226212.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370237.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 41% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..719
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..719
                     /product="tyrosine-protein phosphatase non-receptor type 5
                     isoform X1"
                     /calculated_mol_wt=78959
     Region          298..>453
                     /region_name="PTP_DSP_cys"
                     /note="cys-based protein tyrosine phosphatase and
                     dual-specificity phosphatase superfamily; cl28904"
                     /db_xref="CDD:475123"
     Region          <477..686
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..719
                     /gene="PTPN5"
                     /gene_synonym="PTPSTEP; STEP; STEP61"
                     /coded_by="XM_054370237.1:1311..3470"
                     /db_xref="GeneID:84867"
                     /db_xref="HGNC:HGNC:9657"
                     /db_xref="MIM:176879"
ORIGIN      
        1 mnyegarser enhaaddseg galdmccser lpglpqpivm ealdeaeglq dsqrempppp
       61 ppsppsdpaq kppprgagsh sltvrsslcl faasqfllac gvlwfsgygh iwsqnatnlv
      121 sslltllkql eptawldsgt wgvpslllvf lsvglvlvtt lvwhllrtpa epptplpped
      181 rrqsvsrqps ftysewmeek ieddfldldp vpetpvfdcv mdikpeadpt sltvksmglq
      241 errgsnvslt ldmctpgcne egfgylmspr eesareylls asrvlqaeel hekaldpfll
      301 qaeffeipmn fvdpkeydip glvrknrykt ilpnphsrvc ltspdpddpl ssyinanyir
      361 gyggeekvyi atqgpivstv adfwrmvwqe htpiivmitn ieemnekcte ywpeeqvayd
      421 gveitvqkvi htedyrlrli slkcrdwedr llhchqhllp aaaaggcggh pedhvpapsg
      481 qgrhdpdmra vpvcaprhep lrkaavppvp rmtalllqgs lgtaqpesrp spralprvlg
      541 llpasspsvs slcplsawpd pyppallfll yilgsggqgr egtcqarpga pgpdphhadp
      601 glqfltmvps ipdpecfrat lcvllqcvls vhpslpsvpd tvspqpgrgn elqplsnrtc
      661 lprphphfsq kaddgelgmg ssrrspesfq lresslgwsg hhsqgglwvs dalrrvpsl
//
LOCUS       XP_054226213             719 aa            linear   PRI 05-AUG-2025
DEFINITION  tyrosine-protein phosphatase non-receptor type 5 isoform X1 [Homo
            sapiens].
ACCESSION   XP_054226213
VERSION     XP_054226213.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370238.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 41% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..719
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..719
                     /product="tyrosine-protein phosphatase non-receptor type 5
                     isoform X1"
                     /calculated_mol_wt=78959
     Region          298..>453
                     /region_name="PTP_DSP_cys"
                     /note="cys-based protein tyrosine phosphatase and
                     dual-specificity phosphatase superfamily; cl28904"
                     /db_xref="CDD:475123"
     Region          <477..686
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..719
                     /gene="PTPN5"
                     /gene_synonym="PTPSTEP; STEP; STEP61"
                     /coded_by="XM_054370238.1:1266..3425"
                     /db_xref="GeneID:84867"
                     /db_xref="HGNC:HGNC:9657"
                     /db_xref="MIM:176879"
ORIGIN      
        1 mnyegarser enhaaddseg galdmccser lpglpqpivm ealdeaeglq dsqrempppp
       61 ppsppsdpaq kppprgagsh sltvrsslcl faasqfllac gvlwfsgygh iwsqnatnlv
      121 sslltllkql eptawldsgt wgvpslllvf lsvglvlvtt lvwhllrtpa epptplpped
      181 rrqsvsrqps ftysewmeek ieddfldldp vpetpvfdcv mdikpeadpt sltvksmglq
      241 errgsnvslt ldmctpgcne egfgylmspr eesareylls asrvlqaeel hekaldpfll
      301 qaeffeipmn fvdpkeydip glvrknrykt ilpnphsrvc ltspdpddpl ssyinanyir
      361 gyggeekvyi atqgpivstv adfwrmvwqe htpiivmitn ieemnekcte ywpeeqvayd
      421 gveitvqkvi htedyrlrli slkcrdwedr llhchqhllp aaaaggcggh pedhvpapsg
      481 qgrhdpdmra vpvcaprhep lrkaavppvp rmtalllqgs lgtaqpesrp spralprvlg
      541 llpasspsvs slcplsawpd pyppallfll yilgsggqgr egtcqarpga pgpdphhadp
      601 glqfltmvps ipdpecfrat lcvllqcvls vhpslpsvpd tvspqpgrgn elqplsnrtc
      661 lprphphfsq kaddgelgmg ssrrspesfq lresslgwsg hhsqgglwvs dalrrvpsl
//
LOCUS       XP_054226214             695 aa            linear   PRI 05-AUG-2025
DEFINITION  tyrosine-protein phosphatase non-receptor type 5 isoform X2 [Homo
            sapiens].
ACCESSION   XP_054226214
VERSION     XP_054226214.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370239.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 42% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..695
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..695
                     /product="tyrosine-protein phosphatase non-receptor type 5
                     isoform X2"
                     /calculated_mol_wt=76382
     Region          274..>429
                     /region_name="PTP_DSP_cys"
                     /note="cys-based protein tyrosine phosphatase and
                     dual-specificity phosphatase superfamily; cl28904"
                     /db_xref="CDD:475123"
     Region          <453..662
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..695
                     /gene="PTPN5"
                     /gene_synonym="PTPSTEP; STEP; STEP61"
                     /coded_by="XM_054370239.1:1250..3337"
                     /db_xref="GeneID:84867"
                     /db_xref="HGNC:HGNC:9657"
                     /db_xref="MIM:176879"
ORIGIN      
        1 mccserlpgl pqpivmeald eaeglqdsqr emppppppsp psdpaqkppp rgagshsltv
       61 rsslclfaas qfllacgvlw fsgyghiwsq natnlvssll tllkqlepta wldsgtwgvp
      121 slllvflsvg lvlvttlvwh llrtpaeppt plppedrrqs vsrqpsftys ewmeekiedd
      181 fldldpvpet pvfdcvmdik peadptsltv ksmglqerrg snvsltldmc tpgcneegfg
      241 ylmspreesa reyllsasrv lqaeelheka ldpfllqaef feipmnfvdp keydipglvr
      301 knryktilpn phsrvcltsp dpddplssyi nanyirgygg eekvyiatqg pivstvadfw
      361 rmvwqehtpi ivmitnieem nekcteywpe eqvaydgvei tvqkvihted yrlrlislkc
      421 rdwedrllhc hqhllpaaaa ggcgghpedh vpapsgqgrh dpdmravpvc aprheplrka
      481 avppvprmta lllqgslgta qpesrpspra lprvlgllpa sspsvsslcp lsawpdpypp
      541 allfllyilg sggqgregtc qarpgapgpd phhadpglqf ltmvpsipdp ecfratlcvl
      601 lqcvlsvhps lpsvpdtvsp qpgrgnelqp lsnrtclprp hphfsqkadd gelgmgssrr
      661 spesfqlres slgwsghhsq gglwvsdalr rvpsl
//
LOCUS       XP_054226215             687 aa            linear   PRI 05-AUG-2025
DEFINITION  tyrosine-protein phosphatase non-receptor type 5 isoform X3 [Homo
            sapiens].
ACCESSION   XP_054226215
VERSION     XP_054226215.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370240.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 43% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..687
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..687
                     /product="tyrosine-protein phosphatase non-receptor type 5
                     isoform X3"
                     /calculated_mol_wt=75456
     Region          266..>421
                     /region_name="PTP_DSP_cys"
                     /note="cys-based protein tyrosine phosphatase and
                     dual-specificity phosphatase superfamily; cl28904"
                     /db_xref="CDD:475123"
     Region          <445..641
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..687
                     /gene="PTPN5"
                     /gene_synonym="PTPSTEP; STEP; STEP61"
                     /coded_by="XM_054370240.1:1311..3374"
                     /db_xref="GeneID:84867"
                     /db_xref="HGNC:HGNC:9657"
                     /db_xref="MIM:176879"
ORIGIN      
        1 mnyegarser enhaaddseg galdmccser lpglpqpivm ealdeaeglq dsqrempppp
       61 ppsppsdpaq kppprgagsh sltvrsslcl faasqfllep tawldsgtwg vpslllvfls
      121 vglvlvttlv whllrtpaep ptplppedrr qsvsrqpsft ysewmeekie ddfldldpvp
      181 etpvfdcvmd ikpeadptsl tvksmglqer rgsnvsltld mctpgcneeg fgylmspree
      241 sareyllsas rvlqaeelhe kaldpfllqa effeipmnfv dpkeydipgl vrknryktil
      301 pnphsrvclt spdpddplss yinanyirgy ggeekvyiat qgpivstvad fwrmvwqeht
      361 piivmitnie emnekcteyw peeqvaydgv eitvqkviht edyrlrlisl kcrdwedrll
      421 hchqhllpaa aaggcgghpe dhvpapsgqg rhdpdmravp vcaprheplr kaavppvprm
      481 talllqgslg taqpesrpsp ralprvlgll passpsvssl cplsawpdpy ppallfllyi
      541 lgsggqgreg tcqarpgapg pdphhadpgl qfltmvpsip dpecfratlc vllqcvlsvh
      601 pslpsvpdtv spqpgrgnel qplsnrtclp rphphfsqka ddgelgmgss rrspesfqlr
      661 esslgwsghh sqgglwvsda lrrvpsl
//
LOCUS       XP_054226216             680 aa            linear   PRI 05-AUG-2025
DEFINITION  tyrosine-protein phosphatase non-receptor type 5 isoform X4 [Homo
            sapiens].
ACCESSION   XP_054226216
VERSION     XP_054226216.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370241.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..680
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..680
                     /product="tyrosine-protein phosphatase non-receptor type 5
                     isoform X4"
                     /calculated_mol_wt=74757
     Region          259..>414
                     /region_name="PTP_DSP_cys"
                     /note="cys-based protein tyrosine phosphatase and
                     dual-specificity phosphatase superfamily; cl28904"
                     /db_xref="CDD:475123"
     Region          <438..647
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..680
                     /gene="PTPN5"
                     /gene_synonym="PTPSTEP; STEP; STEP61"
                     /coded_by="XM_054370241.1:163..2205"
                     /db_xref="GeneID:84867"
                     /db_xref="HGNC:HGNC:9657"
                     /db_xref="MIM:176879"
ORIGIN      
        1 mealdeaegl qdsqremppp pppsppsdpa qkppprgags hsltvrsslc lfaasqflla
       61 cgvlwfsgyg hiwsqnatnl vsslltllkq leptawldsg twgvpslllv flsvglvlvt
      121 tlvwhllrtp aepptplppe drrqsvsrqp sftysewmee kieddfldld pvpetpvfdc
      181 vmdikpeadp tsltvksmgl qerrgsnvsl tldmctpgcn eegfgylmsp reesareyll
      241 sasrvlqaee lhekaldpfl lqaeffeipm nfvdpkeydi pglvrknryk tilpnphsrv
      301 cltspdpddp lssyinanyi rgyggeekvy iatqgpivst vadfwrmvwq ehtpiivmit
      361 nieemnekct eywpeeqvay dgveitvqkv ihtedyrlrl islkcrdwed rllhchqhll
      421 paaaaggcgg hpedhvpaps gqgrhdpdmr avpvcaprhe plrkaavppv prmtalllqg
      481 slgtaqpesr pspralprvl gllpasspsv sslcplsawp dpyppallfl lyilgsggqg
      541 regtcqarpg apgpdphhad pglqfltmvp sipdpecfra tlcvllqcvl svhpslpsvp
      601 dtvspqpgrg nelqplsnrt clprphphfs qkaddgelgm gssrrspesf qlresslgws
      661 ghhsqgglwv sdalrrvpsl
//
LOCUS       XP_054226217             663 aa            linear   PRI 05-AUG-2025
DEFINITION  tyrosine-protein phosphatase non-receptor type 5 isoform X5 [Homo
            sapiens].
ACCESSION   XP_054226217
VERSION     XP_054226217.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370242.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 44% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..663
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..663
                     /product="tyrosine-protein phosphatase non-receptor type 5
                     isoform X5"
                     /calculated_mol_wt=72879
     Region          242..>397
                     /region_name="PTP_DSP_cys"
                     /note="cys-based protein tyrosine phosphatase and
                     dual-specificity phosphatase superfamily; cl28904"
                     /db_xref="CDD:475123"
     Region          <421..617
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..663
                     /gene="PTPN5"
                     /gene_synonym="PTPSTEP; STEP; STEP61"
                     /coded_by="XM_054370242.1:1250..3241"
                     /db_xref="GeneID:84867"
                     /db_xref="HGNC:HGNC:9657"
                     /db_xref="MIM:176879"
ORIGIN      
        1 mccserlpgl pqpivmeald eaeglqdsqr emppppppsp psdpaqkppp rgagshsltv
       61 rsslclfaas qflleptawl dsgtwgvpsl llvflsvglv lvttlvwhll rtpaepptpl
      121 ppedrrqsvs rqpsftysew meekieddfl dldpvpetpv fdcvmdikpe adptsltvks
      181 mglqerrgsn vsltldmctp gcneegfgyl mspreesare yllsasrvlq aeelhekald
      241 pfllqaeffe ipmnfvdpke ydipglvrkn ryktilpnph srvcltspdp ddplssyina
      301 nyirgyggee kvyiatqgpi vstvadfwrm vwqehtpiiv mitnieemne kcteywpeeq
      361 vaydgveitv qkvihtedyr lrlislkcrd wedrllhchq hllpaaaagg cgghpedhvp
      421 apsgqgrhdp dmravpvcap rheplrkaav ppvprmtall lqgslgtaqp esrpspralp
      481 rvlgllpass psvsslcpls awpdpyppal lfllyilgsg gqgregtcqa rpgapgpdph
      541 hadpglqflt mvpsipdpec fratlcvllq cvlsvhpslp svpdtvspqp grgnelqpls
      601 nrtclprphp hfsqkaddge lgmgssrrsp esfqlressl gwsghhsqgg lwvsdalrrv
      661 psl
//
LOCUS       XP_054226218             184 aa            linear   PRI 05-AUG-2025
DEFINITION  pseudouridylate synthase RPUSD4, mitochondrial isoform X1 [Homo
            sapiens].
ACCESSION   XP_054226218
VERSION     XP_054226218.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370243.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..184
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..184
                     /product="pseudouridylate synthase RPUSD4, mitochondrial
                     isoform X1"
                     /calculated_mol_wt=20569
     Region          <28..136
                     /region_name="PseudoU_synth"
                     /note="Pseudouridine synthases catalyze the isomerization
                     of specific uridines in an RNA molecule to pseudouridines
                     (5-ribosyluracil, psi); cl00130"
                     /db_xref="CDD:469624"
     CDS             1..184
                     /gene="RPUSD4"
                     /coded_by="XM_054370243.1:159..713"
                     /db_xref="GeneID:84881"
                     /db_xref="HGNC:HGNC:25898"
                     /db_xref="MIM:617488"
ORIGIN      
        1 mpsagvvdip ivekeaqgqq qhhkmtlsps yrmddgkmvk vrrsrnaqva vtqyqvlsst
       61 lssalvelqp itgikhqlrv hlsfgldcpi lgdhkysdwn rlapqklsvg tlkklgleqs
      121 karyiplhlh arqlilpalg sgkeelnlvc klprffvhsl hrlrlempne dqnenneakc
      181 lgaq
//
LOCUS       XP_054226219             264 aa            linear   PRI 05-AUG-2025
DEFINITION  transforming growth factor beta regulator 1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_054226219
VERSION     XP_054226219.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370244.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..264
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..264
                     /product="transforming growth factor beta regulator 1
                     isoform X1"
                     /calculated_mol_wt=29129
     Region          51..91
                     /region_name="FYRN"
                     /note="F/Y-rich N-terminus; pfam05964"
                     /db_xref="CDD:461787"
     Region          97..178
                     /region_name="FYRC"
                     /note="F/Y rich C-terminus; pfam05965"
                     /db_xref="CDD:461788"
     CDS             1..264
                     /gene="TBRG1"
                     /gene_synonym="NIAM; TB-5"
                     /coded_by="XM_054370244.1:221..1015"
                     /db_xref="GeneID:84897"
                     /db_xref="HGNC:HGNC:29551"
                     /db_xref="MIM:610614"
ORIGIN      
        1 mslldglass praplqsska rmkklpkksq nekyrlkylr lrkaakatvf iitdrpgfhd
       61 esaiypvgyc striyasmkc pdqkclytcq ikdggvqpqf eivpeddpqn aivsssadac
      121 haellrtist tmgklmpnll pagadffgfs hpaihnliqs cpgarkciny qwvkfdvckp
      181 gdgqlpeglp endaamsfea fqrqifdedq ndpllpgsld lpelqpaafv ssyqpmylth
      241 eplvdthlqh lkspsqgspi qssd
//
LOCUS       XP_054226220             260 aa            linear   PRI 05-AUG-2025
DEFINITION  transforming growth factor beta regulator 1 isoform X2 [Homo
            sapiens].
ACCESSION   XP_054226220
VERSION     XP_054226220.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370245.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..260
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..260
                     /product="transforming growth factor beta regulator 1
                     isoform X2"
                     /calculated_mol_wt=29026
     Region          46..87
                     /region_name="FYRN"
                     /note="F/Y-rich N-terminus; pfam05964"
                     /db_xref="CDD:461787"
     Region          93..174
                     /region_name="FYRC"
                     /note="F/Y rich C-terminus; pfam05965"
                     /db_xref="CDD:461788"
     CDS             1..260
                     /gene="TBRG1"
                     /gene_synonym="NIAM; TB-5"
                     /coded_by="XM_054370245.1:2921..3703"
                     /db_xref="GeneID:84897"
                     /db_xref="HGNC:HGNC:29551"
                     /db_xref="MIM:610614"
ORIGIN      
        1 mvwpalwely relglfqgpa lglrnhlgrk lrrrkkkkak rttnwkiitd rpgfhdesai
       61 ypvgycstri yasmkcpdqk clytcqikdg gvqpqfeivp eddpqnaivs ssadachael
      121 lrtisttmgk lmpnllpaga dffgfshpai hnliqscpga rkcinyqwvk fdvckpgdgq
      181 lpeglpenda amsfeafqrq ifdedqndpl lpgsldlpel qpaafvssyq pmyltheplv
      241 dthlqhlksp sqgspiqssd
//
LOCUS       XP_054226221             260 aa            linear   PRI 05-AUG-2025
DEFINITION  transforming growth factor beta regulator 1 isoform X2 [Homo
            sapiens].
ACCESSION   XP_054226221
VERSION     XP_054226221.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370246.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 43% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..260
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..260
                     /product="transforming growth factor beta regulator 1
                     isoform X2"
                     /calculated_mol_wt=29026
     Region          46..87
                     /region_name="FYRN"
                     /note="F/Y-rich N-terminus; pfam05964"
                     /db_xref="CDD:461787"
     Region          93..174
                     /region_name="FYRC"
                     /note="F/Y rich C-terminus; pfam05965"
                     /db_xref="CDD:461788"
     CDS             1..260
                     /gene="TBRG1"
                     /gene_synonym="NIAM; TB-5"
                     /coded_by="XM_054370246.1:1206..1988"
                     /db_xref="GeneID:84897"
                     /db_xref="HGNC:HGNC:29551"
                     /db_xref="MIM:610614"
ORIGIN      
        1 mvwpalwely relglfqgpa lglrnhlgrk lrrrkkkkak rttnwkiitd rpgfhdesai
       61 ypvgycstri yasmkcpdqk clytcqikdg gvqpqfeivp eddpqnaivs ssadachael
      121 lrtisttmgk lmpnllpaga dffgfshpai hnliqscpga rkcinyqwvk fdvckpgdgq
      181 lpeglpenda amsfeafqrq ifdedqndpl lpgsldlpel qpaafvssyq pmyltheplv
      241 dthlqhlksp sqgspiqssd
//
LOCUS       XP_054226222             251 aa            linear   PRI 05-AUG-2025
DEFINITION  transforming growth factor beta regulator 1 isoform X3 [Homo
            sapiens].
ACCESSION   XP_054226222
VERSION     XP_054226222.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370247.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..251
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..251
                     /product="transforming growth factor beta regulator 1
                     isoform X3"
                     /calculated_mol_wt=27256
     CDS             1..251
                     /gene="TBRG1"
                     /gene_synonym="NIAM; TB-5"
                     /coded_by="XM_054370247.1:221..976"
                     /db_xref="GeneID:84897"
                     /db_xref="HGNC:HGNC:29551"
                     /db_xref="MIM:610614"
ORIGIN      
        1 mslldglass praplqsska rmkklpkksq nekyrlkylr lrkaakatvf enaaicdeia
       61 rleekflkak eerryllkkl lqlqaltege vqaaapshss slpltygvas svgtiqgagp
      121 isgpstgaee pfgkktkkek kekgkennkl evlkktckkk kmaggarklv qpialdpsgr
      181 pvfpiglggl tvyslgeqqp ladpyqpqri sspcktrsvl satqptlclc vichslqpqs
      241 gskgyhrkld f
//
LOCUS       XP_054226223             211 aa            linear   PRI 05-AUG-2025
DEFINITION  transforming growth factor beta regulator 1 isoform X4 [Homo
            sapiens].
ACCESSION   XP_054226223
VERSION     XP_054226223.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370248.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..211
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..211
                     /product="transforming growth factor beta regulator 1
                     isoform X4"
                     /calculated_mol_wt=22862
     CDS             1..211
                     /gene="TBRG1"
                     /gene_synonym="NIAM; TB-5"
                     /coded_by="XM_054370248.1:221..856"
                     /db_xref="GeneID:84897"
                     /db_xref="HGNC:HGNC:29551"
                     /db_xref="MIM:610614"
ORIGIN      
        1 mslldglass praplqsska rmkklpkksq nekyrlkylr lrkaakatvf enaaicdeia
       61 rleekflkak eerryllkkl lqlqaltege vqaaapshss slpltygvas svgtiqgagp
      121 isgpstgaee pfgkktkkek kekgkennkl evlkktckkk kmaggarklv qpialdpsgr
      181 pvfpiglggl tvyslgepqs gskgyhrkld f
//
LOCUS       XP_054226224             927 aa            linear   PRI 05-AUG-2025
DEFINITION  liprin-beta-2 isoform X1 [Homo sapiens].
ACCESSION   XP_054226224
VERSION     XP_054226224.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370249.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..927
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..927
                     /product="liprin-beta-2 isoform X1"
                     /calculated_mol_wt=103872
     Region          59..>317
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          566..629
                     /region_name="SAM_liprin-beta1,2_repeat1"
                     /note="SAM domain of liprin-beta1,2 proteins repeat 1;
                     cd09563"
                     /db_xref="CDD:188962"
     Region          640..702
                     /region_name="SAM_liprin-beta1,2_repeat2"
                     /note="SAM domain of liprin-beta1,2 proteins repeat 2;
                     cd09566"
                     /db_xref="CDD:188965"
     Region          725..796
                     /region_name="SAM_liprin-beta1,2_repeat3"
                     /note="SAM domain of liprin-beta proteins repeat 3;
                     cd09569"
                     /db_xref="CDD:188968"
     CDS             1..927
                     /gene="PPFIBP2"
                     /gene_synonym="Cclp1"
                     /coded_by="XM_054370249.1:160..2943"
                     /db_xref="GeneID:8495"
                     /db_xref="HGNC:HGNC:9250"
                     /db_xref="MIM:603142"
ORIGIN      
        1 masdashale aaleqmdgii agtktgadls dgtcepglas pasymnpfpv lhliedlrla
       61 lemlelpqer aallsqipgp taayikewfe eslsqvnhhs aasnetyqer larlegdkes
      121 lilqvsvltd qveaqgekir dlevcleghq vklnaaeeml qqellsrtsl etqkldlmte
      181 vselklklvg mekeqreqee kqrkaeellq elrhlkikve elenernqye wklkatkaev
      241 aqlqeqvalk daeierlhsq lsrtaalhse shterdqeiq rlkmgmetll lanedkdrri
      301 eeltgllnqy rkvkeivmvt qgpsertlsi neeepeggfs kwnatnkdpe elfkqemppr
      361 cssptvgppp lpqksletra qkklscsled lrsesvdkcm dgnqpfpvle pkdspflaeh
      421 kyptlpgkls gatpngeaak sppticqpda tgssllrlnr grsvsapvlg dtesgwddta
      481 vvndlsstss gtesgpqspl tpdgkrnpkg ikkfwgkirr tqsgnfytdt lgmaefrrgg
      541 lratagprls rtrdskgqks danapfaqws tervcawled fglaqyvifa rqwvssghtl
      601 ltatpqdmek elgikhplhr kklvlavkai ntkqeeksal ldhiwvtrwl ddiglpqykd
      661 qfhesrvdgr mlqyltvndl lflkvtsqlh hlsikcaihv lhvnkfnphc lhrrpadesn
      721 lspsevvqws nhrvmewlrs vdlaeyapnl rgsgvhggli ileprftgdt lamllnippq
      781 ktllrrhltt kfnaligpea eqekrekmas paytplttta kvrprklgfs hfgnirkkkf
      841 destdyicpm epsdgvsdsh rvysgyrgls pldapeldgl dqmapsegtv tqigllsqdi
      901 hrlttmlsqd qllndsrlpa pnsddwr
//
LOCUS       XP_054226225             927 aa            linear   PRI 05-AUG-2025
DEFINITION  liprin-beta-2 isoform X1 [Homo sapiens].
ACCESSION   XP_054226225
VERSION     XP_054226225.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370250.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..927
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..927
                     /product="liprin-beta-2 isoform X1"
                     /calculated_mol_wt=103872
     Region          59..>317
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          566..629
                     /region_name="SAM_liprin-beta1,2_repeat1"
                     /note="SAM domain of liprin-beta1,2 proteins repeat 1;
                     cd09563"
                     /db_xref="CDD:188962"
     Region          640..702
                     /region_name="SAM_liprin-beta1,2_repeat2"
                     /note="SAM domain of liprin-beta1,2 proteins repeat 2;
                     cd09566"
                     /db_xref="CDD:188965"
     Region          725..796
                     /region_name="SAM_liprin-beta1,2_repeat3"
                     /note="SAM domain of liprin-beta proteins repeat 3;
                     cd09569"
                     /db_xref="CDD:188968"
     CDS             1..927
                     /gene="PPFIBP2"
                     /gene_synonym="Cclp1"
                     /coded_by="XM_054370250.1:316..3099"
                     /db_xref="GeneID:8495"
                     /db_xref="HGNC:HGNC:9250"
                     /db_xref="MIM:603142"
ORIGIN      
        1 masdashale aaleqmdgii agtktgadls dgtcepglas pasymnpfpv lhliedlrla
       61 lemlelpqer aallsqipgp taayikewfe eslsqvnhhs aasnetyqer larlegdkes
      121 lilqvsvltd qveaqgekir dlevcleghq vklnaaeeml qqellsrtsl etqkldlmte
      181 vselklklvg mekeqreqee kqrkaeellq elrhlkikve elenernqye wklkatkaev
      241 aqlqeqvalk daeierlhsq lsrtaalhse shterdqeiq rlkmgmetll lanedkdrri
      301 eeltgllnqy rkvkeivmvt qgpsertlsi neeepeggfs kwnatnkdpe elfkqemppr
      361 cssptvgppp lpqksletra qkklscsled lrsesvdkcm dgnqpfpvle pkdspflaeh
      421 kyptlpgkls gatpngeaak sppticqpda tgssllrlnr grsvsapvlg dtesgwddta
      481 vvndlsstss gtesgpqspl tpdgkrnpkg ikkfwgkirr tqsgnfytdt lgmaefrrgg
      541 lratagprls rtrdskgqks danapfaqws tervcawled fglaqyvifa rqwvssghtl
      601 ltatpqdmek elgikhplhr kklvlavkai ntkqeeksal ldhiwvtrwl ddiglpqykd
      661 qfhesrvdgr mlqyltvndl lflkvtsqlh hlsikcaihv lhvnkfnphc lhrrpadesn
      721 lspsevvqws nhrvmewlrs vdlaeyapnl rgsgvhggli ileprftgdt lamllnippq
      781 ktllrrhltt kfnaligpea eqekrekmas paytplttta kvrprklgfs hfgnirkkkf
      841 destdyicpm epsdgvsdsh rvysgyrgls pldapeldgl dqmapsegtv tqigllsqdi
      901 hrlttmlsqd qllndsrlpa pnsddwr
//
LOCUS       XP_054226226             927 aa            linear   PRI 05-AUG-2025
DEFINITION  liprin-beta-2 isoform X1 [Homo sapiens].
ACCESSION   XP_054226226
VERSION     XP_054226226.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370251.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..927
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..927
                     /product="liprin-beta-2 isoform X1"
                     /calculated_mol_wt=103872
     Region          59..>317
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          566..629
                     /region_name="SAM_liprin-beta1,2_repeat1"
                     /note="SAM domain of liprin-beta1,2 proteins repeat 1;
                     cd09563"
                     /db_xref="CDD:188962"
     Region          640..702
                     /region_name="SAM_liprin-beta1,2_repeat2"
                     /note="SAM domain of liprin-beta1,2 proteins repeat 2;
                     cd09566"
                     /db_xref="CDD:188965"
     Region          725..796
                     /region_name="SAM_liprin-beta1,2_repeat3"
                     /note="SAM domain of liprin-beta proteins repeat 3;
                     cd09569"
                     /db_xref="CDD:188968"
     CDS             1..927
                     /gene="PPFIBP2"
                     /gene_synonym="Cclp1"
                     /coded_by="XM_054370251.1:133..2916"
                     /db_xref="GeneID:8495"
                     /db_xref="HGNC:HGNC:9250"
                     /db_xref="MIM:603142"
ORIGIN      
        1 masdashale aaleqmdgii agtktgadls dgtcepglas pasymnpfpv lhliedlrla
       61 lemlelpqer aallsqipgp taayikewfe eslsqvnhhs aasnetyqer larlegdkes
      121 lilqvsvltd qveaqgekir dlevcleghq vklnaaeeml qqellsrtsl etqkldlmte
      181 vselklklvg mekeqreqee kqrkaeellq elrhlkikve elenernqye wklkatkaev
      241 aqlqeqvalk daeierlhsq lsrtaalhse shterdqeiq rlkmgmetll lanedkdrri
      301 eeltgllnqy rkvkeivmvt qgpsertlsi neeepeggfs kwnatnkdpe elfkqemppr
      361 cssptvgppp lpqksletra qkklscsled lrsesvdkcm dgnqpfpvle pkdspflaeh
      421 kyptlpgkls gatpngeaak sppticqpda tgssllrlnr grsvsapvlg dtesgwddta
      481 vvndlsstss gtesgpqspl tpdgkrnpkg ikkfwgkirr tqsgnfytdt lgmaefrrgg
      541 lratagprls rtrdskgqks danapfaqws tervcawled fglaqyvifa rqwvssghtl
      601 ltatpqdmek elgikhplhr kklvlavkai ntkqeeksal ldhiwvtrwl ddiglpqykd
      661 qfhesrvdgr mlqyltvndl lflkvtsqlh hlsikcaihv lhvnkfnphc lhrrpadesn
      721 lspsevvqws nhrvmewlrs vdlaeyapnl rgsgvhggli ileprftgdt lamllnippq
      781 ktllrrhltt kfnaligpea eqekrekmas paytplttta kvrprklgfs hfgnirkkkf
      841 destdyicpm epsdgvsdsh rvysgyrgls pldapeldgl dqmapsegtv tqigllsqdi
      901 hrlttmlsqd qllndsrlpa pnsddwr
//
LOCUS       XP_054226227             916 aa            linear   PRI 05-AUG-2025
DEFINITION  liprin-beta-2 isoform X2 [Homo sapiens].
ACCESSION   XP_054226227
VERSION     XP_054226227.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370252.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..916
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..916
                     /product="liprin-beta-2 isoform X2"
                     /calculated_mol_wt=102834
     Region          59..>317
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          555..618
                     /region_name="SAM_liprin-beta1,2_repeat1"
                     /note="SAM domain of liprin-beta1,2 proteins repeat 1;
                     cd09563"
                     /db_xref="CDD:188962"
     Region          629..691
                     /region_name="SAM_liprin-beta1,2_repeat2"
                     /note="SAM domain of liprin-beta1,2 proteins repeat 2;
                     cd09566"
                     /db_xref="CDD:188965"
     Region          714..785
                     /region_name="SAM_liprin-beta1,2_repeat3"
                     /note="SAM domain of liprin-beta proteins repeat 3;
                     cd09569"
                     /db_xref="CDD:188968"
     CDS             1..916
                     /gene="PPFIBP2"
                     /gene_synonym="Cclp1"
                     /coded_by="XM_054370252.1:160..2910"
                     /db_xref="GeneID:8495"
                     /db_xref="HGNC:HGNC:9250"
                     /db_xref="MIM:603142"
ORIGIN      
        1 masdashale aaleqmdgii agtktgadls dgtcepglas pasymnpfpv lhliedlrla
       61 lemlelpqer aallsqipgp taayikewfe eslsqvnhhs aasnetyqer larlegdkes
      121 lilqvsvltd qveaqgekir dlevcleghq vklnaaeeml qqellsrtsl etqkldlmte
      181 vselklklvg mekeqreqee kqrkaeellq elrhlkikve elenernqye wklkatkaev
      241 aqlqeqvalk daeierlhsq lsrtaalhse shterdqeiq rlkmgmetll lanedkdrri
      301 eeltgllnqy rkvkeivmvt qgpsertlsi neeepeggfs kwnatnkdpe elfkqemppr
      361 cssptvgppp lpqksletra qkklscsled lrsesvdkcm dgnqpfpvle pkdspflaeh
      421 kyptlpgkls gatpngeaak sppticqpda tgssllrlrd tesgwddtav vndlsstssg
      481 tesgpqsplt pdgkrnpkgi kkfwgkirrt qsgnfytdtl gmaefrrggl ratagprlsr
      541 trdskgqksd anapfaqwst ervcawledf glaqyvifar qwvssghtll tatpqdmeke
      601 lgikhplhrk klvlavkain tkqeeksall dhiwvtrwld diglpqykdq fhesrvdgrm
      661 lqyltvndll flkvtsqlhh lsikcaihvl hvnkfnphcl hrrpadesnl spsevvqwsn
      721 hrvmewlrsv dlaeyapnlr gsgvhgglii leprftgdtl amllnippqk tllrrhlttk
      781 fnaligpeae qekrekmasp aytpltttak vrprklgfsh fgnirkkkfd estdyicpme
      841 psdgvsdshr vysgyrglsp ldapeldgld qmapsegtvt qigllsqdih rlttmlsqdq
      901 llndsrlpap nsddwr
//
LOCUS       XP_054226228             916 aa            linear   PRI 05-AUG-2025
DEFINITION  liprin-beta-2 isoform X2 [Homo sapiens].
ACCESSION   XP_054226228
VERSION     XP_054226228.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370253.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..916
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..916
                     /product="liprin-beta-2 isoform X2"
                     /calculated_mol_wt=102834
     Region          59..>317
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          555..618
                     /region_name="SAM_liprin-beta1,2_repeat1"
                     /note="SAM domain of liprin-beta1,2 proteins repeat 1;
                     cd09563"
                     /db_xref="CDD:188962"
     Region          629..691
                     /region_name="SAM_liprin-beta1,2_repeat2"
                     /note="SAM domain of liprin-beta1,2 proteins repeat 2;
                     cd09566"
                     /db_xref="CDD:188965"
     Region          714..785
                     /region_name="SAM_liprin-beta1,2_repeat3"
                     /note="SAM domain of liprin-beta proteins repeat 3;
                     cd09569"
                     /db_xref="CDD:188968"
     CDS             1..916
                     /gene="PPFIBP2"
                     /gene_synonym="Cclp1"
                     /coded_by="XM_054370253.1:316..3066"
                     /db_xref="GeneID:8495"
                     /db_xref="HGNC:HGNC:9250"
                     /db_xref="MIM:603142"
ORIGIN      
        1 masdashale aaleqmdgii agtktgadls dgtcepglas pasymnpfpv lhliedlrla
       61 lemlelpqer aallsqipgp taayikewfe eslsqvnhhs aasnetyqer larlegdkes
      121 lilqvsvltd qveaqgekir dlevcleghq vklnaaeeml qqellsrtsl etqkldlmte
      181 vselklklvg mekeqreqee kqrkaeellq elrhlkikve elenernqye wklkatkaev
      241 aqlqeqvalk daeierlhsq lsrtaalhse shterdqeiq rlkmgmetll lanedkdrri
      301 eeltgllnqy rkvkeivmvt qgpsertlsi neeepeggfs kwnatnkdpe elfkqemppr
      361 cssptvgppp lpqksletra qkklscsled lrsesvdkcm dgnqpfpvle pkdspflaeh
      421 kyptlpgkls gatpngeaak sppticqpda tgssllrlrd tesgwddtav vndlsstssg
      481 tesgpqsplt pdgkrnpkgi kkfwgkirrt qsgnfytdtl gmaefrrggl ratagprlsr
      541 trdskgqksd anapfaqwst ervcawledf glaqyvifar qwvssghtll tatpqdmeke
      601 lgikhplhrk klvlavkain tkqeeksall dhiwvtrwld diglpqykdq fhesrvdgrm
      661 lqyltvndll flkvtsqlhh lsikcaihvl hvnkfnphcl hrrpadesnl spsevvqwsn
      721 hrvmewlrsv dlaeyapnlr gsgvhgglii leprftgdtl amllnippqk tllrrhlttk
      781 fnaligpeae qekrekmasp aytpltttak vrprklgfsh fgnirkkkfd estdyicpme
      841 psdgvsdshr vysgyrglsp ldapeldgld qmapsegtvt qigllsqdih rlttmlsqdq
      901 llndsrlpap nsddwr
//
LOCUS       XP_054226229             900 aa            linear   PRI 05-AUG-2025
DEFINITION  liprin-beta-2 isoform X3 [Homo sapiens].
ACCESSION   XP_054226229
VERSION     XP_054226229.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370254.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..900
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..900
                     /product="liprin-beta-2 isoform X3"
                     /calculated_mol_wt=100723
     Region          59..>317
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          566..629
                     /region_name="SAM_liprin-beta1,2_repeat1"
                     /note="SAM domain of liprin-beta1,2 proteins repeat 1;
                     cd09563"
                     /db_xref="CDD:188962"
     Region          640..702
                     /region_name="SAM_liprin-beta1,2_repeat2"
                     /note="SAM domain of liprin-beta1,2 proteins repeat 2;
                     cd09566"
                     /db_xref="CDD:188965"
     Region          725..796
                     /region_name="SAM_liprin-beta1,2_repeat3"
                     /note="SAM domain of liprin-beta proteins repeat 3;
                     cd09569"
                     /db_xref="CDD:188968"
     CDS             1..900
                     /gene="PPFIBP2"
                     /gene_synonym="Cclp1"
                     /coded_by="XM_054370254.1:160..2862"
                     /db_xref="GeneID:8495"
                     /db_xref="HGNC:HGNC:9250"
                     /db_xref="MIM:603142"
ORIGIN      
        1 masdashale aaleqmdgii agtktgadls dgtcepglas pasymnpfpv lhliedlrla
       61 lemlelpqer aallsqipgp taayikewfe eslsqvnhhs aasnetyqer larlegdkes
      121 lilqvsvltd qveaqgekir dlevcleghq vklnaaeeml qqellsrtsl etqkldlmte
      181 vselklklvg mekeqreqee kqrkaeellq elrhlkikve elenernqye wklkatkaev
      241 aqlqeqvalk daeierlhsq lsrtaalhse shterdqeiq rlkmgmetll lanedkdrri
      301 eeltgllnqy rkvkeivmvt qgpsertlsi neeepeggfs kwnatnkdpe elfkqemppr
      361 cssptvgppp lpqksletra qkklscsled lrsesvdkcm dgnqpfpvle pkdspflaeh
      421 kyptlpgkls gatpngeaak sppticqpda tgssllrlnr grsvsapvlg dtesgwddta
      481 vvndlsstss gtesgpqspl tpdgkrnpkg ikkfwgkirr tqsgnfytdt lgmaefrrgg
      541 lratagprls rtrdskgqks danapfaqws tervcawled fglaqyvifa rqwvssghtl
      601 ltatpqdmek elgikhplhr kklvlavkai ntkqeeksal ldhiwvtrwl ddiglpqykd
      661 qfhesrvdgr mlqyltvndl lflkvtsqlh hlsikcaihv lhvnkfnphc lhrrpadesn
      721 lspsevvqws nhrvmewlrs vdlaeyapnl rgsgvhggli ileprftgdt lamllnippq
      781 ktllrrhltt kfnaligpea eqekrekmas paytplttta kvrprklgfs hfgnirkkkf
      841 destdyicpm epsdgvsdsh rvysgyrgls pldapeldgl dqkrsnteka ppgpsscsld
//
LOCUS       XP_054226230             897 aa            linear   PRI 05-AUG-2025
DEFINITION  liprin-beta-2 isoform X4 [Homo sapiens].
ACCESSION   XP_054226230
VERSION     XP_054226230.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370255.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..897
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..897
                     /product="liprin-beta-2 isoform X4"
                     /calculated_mol_wt=100335
     Region          59..>317
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          566..629
                     /region_name="SAM_liprin-beta1,2_repeat1"
                     /note="SAM domain of liprin-beta1,2 proteins repeat 1;
                     cd09563"
                     /db_xref="CDD:188962"
     Region          640..702
                     /region_name="SAM_liprin-beta1,2_repeat2"
                     /note="SAM domain of liprin-beta1,2 proteins repeat 2;
                     cd09566"
                     /db_xref="CDD:188965"
     Region          725..796
                     /region_name="SAM_liprin-beta1,2_repeat3"
                     /note="SAM domain of liprin-beta proteins repeat 3;
                     cd09569"
                     /db_xref="CDD:188968"
     CDS             1..897
                     /gene="PPFIBP2"
                     /gene_synonym="Cclp1"
                     /coded_by="XM_054370255.1:160..2853"
                     /db_xref="GeneID:8495"
                     /db_xref="HGNC:HGNC:9250"
                     /db_xref="MIM:603142"
ORIGIN      
        1 masdashale aaleqmdgii agtktgadls dgtcepglas pasymnpfpv lhliedlrla
       61 lemlelpqer aallsqipgp taayikewfe eslsqvnhhs aasnetyqer larlegdkes
      121 lilqvsvltd qveaqgekir dlevcleghq vklnaaeeml qqellsrtsl etqkldlmte
      181 vselklklvg mekeqreqee kqrkaeellq elrhlkikve elenernqye wklkatkaev
      241 aqlqeqvalk daeierlhsq lsrtaalhse shterdqeiq rlkmgmetll lanedkdrri
      301 eeltgllnqy rkvkeivmvt qgpsertlsi neeepeggfs kwnatnkdpe elfkqemppr
      361 cssptvgppp lpqksletra qkklscsled lrsesvdkcm dgnqpfpvle pkdspflaeh
      421 kyptlpgkls gatpngeaak sppticqpda tgssllrlnr grsvsapvlg dtesgwddta
      481 vvndlsstss gtesgpqspl tpdgkrnpkg ikkfwgkirr tqsgnfytdt lgmaefrrgg
      541 lratagprls rtrdskgqks danapfaqws tervcawled fglaqyvifa rqwvssghtl
      601 ltatpqdmek elgikhplhr kklvlavkai ntkqeeksal ldhiwvtrwl ddiglpqykd
      661 qfhesrvdgr mlqyltvndl lflkvtsqlh hlsikcaihv lhvnkfnphc lhrrpadesn
      721 lspsevvqws nhrvmewlrs vdlaeyapnl rgsgvhggli ileprftgdt lamllnippq
      781 ktllrrhltt kfnaligpea eqekrekmas paytplttta kvrprklgfs hfgnirkkkf
      841 destdyicpm epsdgvsdsh rvysgyrgls pldapeldgl dqmapsedna epgpaae
//
LOCUS       XP_054226231             889 aa            linear   PRI 05-AUG-2025
DEFINITION  liprin-beta-2 isoform X5 [Homo sapiens].
ACCESSION   XP_054226231
VERSION     XP_054226231.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370256.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..889
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..889
                     /product="liprin-beta-2 isoform X5"
                     /calculated_mol_wt=99685
     Region          59..>317
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          555..618
                     /region_name="SAM_liprin-beta1,2_repeat1"
                     /note="SAM domain of liprin-beta1,2 proteins repeat 1;
                     cd09563"
                     /db_xref="CDD:188962"
     Region          629..691
                     /region_name="SAM_liprin-beta1,2_repeat2"
                     /note="SAM domain of liprin-beta1,2 proteins repeat 2;
                     cd09566"
                     /db_xref="CDD:188965"
     Region          714..785
                     /region_name="SAM_liprin-beta1,2_repeat3"
                     /note="SAM domain of liprin-beta proteins repeat 3;
                     cd09569"
                     /db_xref="CDD:188968"
     CDS             1..889
                     /gene="PPFIBP2"
                     /gene_synonym="Cclp1"
                     /coded_by="XM_054370256.1:160..2829"
                     /db_xref="GeneID:8495"
                     /db_xref="HGNC:HGNC:9250"
                     /db_xref="MIM:603142"
ORIGIN      
        1 masdashale aaleqmdgii agtktgadls dgtcepglas pasymnpfpv lhliedlrla
       61 lemlelpqer aallsqipgp taayikewfe eslsqvnhhs aasnetyqer larlegdkes
      121 lilqvsvltd qveaqgekir dlevcleghq vklnaaeeml qqellsrtsl etqkldlmte
      181 vselklklvg mekeqreqee kqrkaeellq elrhlkikve elenernqye wklkatkaev
      241 aqlqeqvalk daeierlhsq lsrtaalhse shterdqeiq rlkmgmetll lanedkdrri
      301 eeltgllnqy rkvkeivmvt qgpsertlsi neeepeggfs kwnatnkdpe elfkqemppr
      361 cssptvgppp lpqksletra qkklscsled lrsesvdkcm dgnqpfpvle pkdspflaeh
      421 kyptlpgkls gatpngeaak sppticqpda tgssllrlrd tesgwddtav vndlsstssg
      481 tesgpqsplt pdgkrnpkgi kkfwgkirrt qsgnfytdtl gmaefrrggl ratagprlsr
      541 trdskgqksd anapfaqwst ervcawledf glaqyvifar qwvssghtll tatpqdmeke
      601 lgikhplhrk klvlavkain tkqeeksall dhiwvtrwld diglpqykdq fhesrvdgrm
      661 lqyltvndll flkvtsqlhh lsikcaihvl hvnkfnphcl hrrpadesnl spsevvqwsn
      721 hrvmewlrsv dlaeyapnlr gsgvhgglii leprftgdtl amllnippqk tllrrhlttk
      781 fnaligpeae qekrekmasp aytpltttak vrprklgfsh fgnirkkkfd estdyicpme
      841 psdgvsdshr vysgyrglsp ldapeldgld qkrsntekap pgpsscsld
//
LOCUS       XP_054226232             858 aa            linear   PRI 05-AUG-2025
DEFINITION  liprin-beta-2 isoform X6 [Homo sapiens].
ACCESSION   XP_054226232
VERSION     XP_054226232.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370257.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..858
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..858
                     /product="liprin-beta-2 isoform X6"
                     /calculated_mol_wt=96609
     Region          <36..>248
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          497..560
                     /region_name="SAM_liprin-beta1,2_repeat1"
                     /note="SAM domain of liprin-beta1,2 proteins repeat 1;
                     cd09563"
                     /db_xref="CDD:188962"
     Region          571..633
                     /region_name="SAM_liprin-beta1,2_repeat2"
                     /note="SAM domain of liprin-beta1,2 proteins repeat 2;
                     cd09566"
                     /db_xref="CDD:188965"
     Region          656..727
                     /region_name="SAM_liprin-beta1,2_repeat3"
                     /note="SAM domain of liprin-beta proteins repeat 3;
                     cd09569"
                     /db_xref="CDD:188968"
     CDS             1..858
                     /gene="PPFIBP2"
                     /gene_synonym="Cclp1"
                     /coded_by="XM_054370257.1:1013..3589"
                     /db_xref="GeneID:8495"
                     /db_xref="HGNC:HGNC:9250"
                     /db_xref="MIM:603142"
ORIGIN      
        1 mwlstvmadr ggqrlgsrrt vkatsqvnhh saasnetyqe rlarlegdke slilqvsvlt
       61 dqveaqgeki rdlevclegh qvklnaaeem lqqellsrts letqkldlmt evselklklv
      121 gmekeqreqe ekqrkaeell qelrhlkikv eelenernqy ewklkatkae vaqlqeqval
      181 kdaeierlhs qlsrtaalhs eshterdqei qrlkmgmetl llanedkdrr ieeltgllnq
      241 yrkvkeivmv tqgpsertls ineeepeggf skwnatnkdp eelfkqempp rcssptvgpp
      301 plpqksletr aqkklscsle dlrsesvdkc mdgnqpfpvl epkdspflae hkyptlpgkl
      361 sgatpngeaa ksppticqpd atgssllrln rgrsvsapvl gdtesgwddt avvndlssts
      421 sgtesgpqsp ltpdgkrnpk gikkfwgkir rtqsgnfytd tlgmaefrrg glratagprl
      481 srtrdskgqk sdanapfaqw stervcawle dfglaqyvif arqwvssght lltatpqdme
      541 kelgikhplh rkklvlavka intkqeeksa lldhiwvtrw lddiglpqyk dqfhesrvdg
      601 rmlqyltvnd llflkvtsql hhlsikcaih vlhvnkfnph clhrrpades nlspsevvqw
      661 snhrvmewlr svdlaeyapn lrgsgvhggl iileprftgd tlamllnipp qktllrrhlt
      721 tkfnaligpe aeqekrekma spaytplttt akvrprklgf shfgnirkkk fdestdyicp
      781 mepsdgvsds hrvysgyrgl spldapeldg ldqmapsegt vtqigllsqd ihrlttmlsq
      841 dqllndsrlp apnsddwr
//
LOCUS       XP_054226233             847 aa            linear   PRI 05-AUG-2025
DEFINITION  liprin-beta-2 isoform X7 [Homo sapiens].
ACCESSION   XP_054226233
VERSION     XP_054226233.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370258.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..847
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..847
                     /product="liprin-beta-2 isoform X7"
                     /calculated_mol_wt=95571
     Region          <36..>248
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          486..549
                     /region_name="SAM_liprin-beta1,2_repeat1"
                     /note="SAM domain of liprin-beta1,2 proteins repeat 1;
                     cd09563"
                     /db_xref="CDD:188962"
     Region          560..622
                     /region_name="SAM_liprin-beta1,2_repeat2"
                     /note="SAM domain of liprin-beta1,2 proteins repeat 2;
                     cd09566"
                     /db_xref="CDD:188965"
     Region          645..716
                     /region_name="SAM_liprin-beta1,2_repeat3"
                     /note="SAM domain of liprin-beta proteins repeat 3;
                     cd09569"
                     /db_xref="CDD:188968"
     CDS             1..847
                     /gene="PPFIBP2"
                     /gene_synonym="Cclp1"
                     /coded_by="XM_054370258.1:1013..3556"
                     /db_xref="GeneID:8495"
                     /db_xref="HGNC:HGNC:9250"
                     /db_xref="MIM:603142"
ORIGIN      
        1 mwlstvmadr ggqrlgsrrt vkatsqvnhh saasnetyqe rlarlegdke slilqvsvlt
       61 dqveaqgeki rdlevclegh qvklnaaeem lqqellsrts letqkldlmt evselklklv
      121 gmekeqreqe ekqrkaeell qelrhlkikv eelenernqy ewklkatkae vaqlqeqval
      181 kdaeierlhs qlsrtaalhs eshterdqei qrlkmgmetl llanedkdrr ieeltgllnq
      241 yrkvkeivmv tqgpsertls ineeepeggf skwnatnkdp eelfkqempp rcssptvgpp
      301 plpqksletr aqkklscsle dlrsesvdkc mdgnqpfpvl epkdspflae hkyptlpgkl
      361 sgatpngeaa ksppticqpd atgssllrlr dtesgwddta vvndlsstss gtesgpqspl
      421 tpdgkrnpkg ikkfwgkirr tqsgnfytdt lgmaefrrgg lratagprls rtrdskgqks
      481 danapfaqws tervcawled fglaqyvifa rqwvssghtl ltatpqdmek elgikhplhr
      541 kklvlavkai ntkqeeksal ldhiwvtrwl ddiglpqykd qfhesrvdgr mlqyltvndl
      601 lflkvtsqlh hlsikcaihv lhvnkfnphc lhrrpadesn lspsevvqws nhrvmewlrs
      661 vdlaeyapnl rgsgvhggli ileprftgdt lamllnippq ktllrrhltt kfnaligpea
      721 eqekrekmas paytplttta kvrprklgfs hfgnirkkkf destdyicpm epsdgvsdsh
      781 rvysgyrgls pldapeldgl dqmapsegtv tqigllsqdi hrlttmlsqd qllndsrlpa
      841 pnsddwr
//
LOCUS       XP_054226234             839 aa            linear   PRI 05-AUG-2025
DEFINITION  liprin-beta-2 isoform X8 [Homo sapiens].
ACCESSION   XP_054226234
VERSION     XP_054226234.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370259.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..839
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..839
                     /product="liprin-beta-2 isoform X8"
                     /calculated_mol_wt=94903
     Region          <14..>240
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          478..541
                     /region_name="SAM_liprin-beta1,2_repeat1"
                     /note="SAM domain of liprin-beta1,2 proteins repeat 1;
                     cd09563"
                     /db_xref="CDD:188962"
     Region          552..614
                     /region_name="SAM_liprin-beta1,2_repeat2"
                     /note="SAM domain of liprin-beta1,2 proteins repeat 2;
                     cd09566"
                     /db_xref="CDD:188965"
     Region          637..708
                     /region_name="SAM_liprin-beta1,2_repeat3"
                     /note="SAM domain of liprin-beta proteins repeat 3;
                     cd09569"
                     /db_xref="CDD:188968"
     CDS             1..839
                     /gene="PPFIBP2"
                     /gene_synonym="Cclp1"
                     /coded_by="XM_054370259.1:556..3075"
                     /db_xref="GeneID:8495"
                     /db_xref="HGNC:HGNC:9250"
                     /db_xref="MIM:603142"
ORIGIN      
        1 mdgdidvykh fswlkrsqvn hhsaasnety qerlarlegd keslilqvsv ltdqveaqge
       61 kirdlevcle ghqvklnaae emlqqellsr tsletqkldl mtevselklk lvgmekeqre
      121 qeekqrkaee llqelrhlki kveelenern qyewklkatk aevaqlqeqv alkdaeierl
      181 hsqlsrtaal hseshterdq eiqrlkmgme tlllanedkd rrieeltgll nqyrkvkeiv
      241 mvtqgpsert lsineeepeg gfskwnatnk dpeelfkqem pprcssptvg ppplpqksle
      301 traqkklscs ledlrsesvd kcmdgnqpfp vlepkdspfl aehkyptlpg klsgatpnge
      361 aaksppticq pdatgssllr lrdtesgwdd tavvndlsst ssgtesgpqs pltpdgkrnp
      421 kgikkfwgki rrtqsgnfyt dtlgmaefrr gglratagpr lsrtrdskgq ksdanapfaq
      481 wstervcawl edfglaqyvi farqwvssgh tlltatpqdm ekelgikhpl hrkklvlavk
      541 aintkqeeks alldhiwvtr wlddiglpqy kdqfhesrvd grmlqyltvn dllflkvtsq
      601 lhhlsikcai hvlhvnkfnp hclhrrpade snlspsevvq wsnhrvmewl rsvdlaeyap
      661 nlrgsgvhgg liileprftg dtlamllnip pqktllrrhl ttkfnaligp eaeqekrekm
      721 aspaytpltt takvrprklg fshfgnirkk kfdestdyic pmepsdgvsd shrvysgyrg
      781 lspldapeld gldqmapseg tvtqigllsq dihrlttmls qdqllndsrl papnsddwr
//
LOCUS       XP_054226235             815 aa            linear   PRI 05-AUG-2025
DEFINITION  liprin-beta-2 isoform X9 [Homo sapiens].
ACCESSION   XP_054226235
VERSION     XP_054226235.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370260.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..815
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..815
                     /product="liprin-beta-2 isoform X9"
                     /calculated_mol_wt=91840
     Region          <1..>205
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          454..517
                     /region_name="SAM_liprin-beta1,2_repeat1"
                     /note="SAM domain of liprin-beta1,2 proteins repeat 1;
                     cd09563"
                     /db_xref="CDD:188962"
     Region          528..590
                     /region_name="SAM_liprin-beta1,2_repeat2"
                     /note="SAM domain of liprin-beta1,2 proteins repeat 2;
                     cd09566"
                     /db_xref="CDD:188965"
     Region          613..684
                     /region_name="SAM_liprin-beta1,2_repeat3"
                     /note="SAM domain of liprin-beta proteins repeat 3;
                     cd09569"
                     /db_xref="CDD:188968"
     CDS             1..815
                     /gene="PPFIBP2"
                     /gene_synonym="Cclp1"
                     /coded_by="XM_054370260.1:150..2597"
                     /db_xref="GeneID:8495"
                     /db_xref="HGNC:HGNC:9250"
                     /db_xref="MIM:603142"
ORIGIN      
        1 msseqwprlp gkvsvltdqv eaqgekirdl evcleghqvk lnaaeemlqq ellsrtslet
       61 qkldlmtevs elklklvgme keqreqeekq rkaeellqel rhlkikveel enernqyewk
      121 lkatkaevaq lqeqvalkda eierlhsqls rtaalhsesh terdqeiqrl kmgmetllla
      181 nedkdrriee ltgllnqyrk vkeivmvtqg psertlsine eepeggfskw natnkdpeel
      241 fkqempprcs sptvgppplp qksletraqk klscsledlr sesvdkcmdg nqpfpvlepk
      301 dspflaehky ptlpgklsga tpngeaaksp pticqpdatg ssllrlnrgr svsapvlgdt
      361 esgwddtavv ndlsstssgt esgpqspltp dgkrnpkgik kfwgkirrtq sgnfytdtlg
      421 maefrrgglr atagprlsrt rdskgqksda napfaqwste rvcawledfg laqyvifarq
      481 wvssghtllt atpqdmekel gikhplhrkk lvlavkaint kqeeksalld hiwvtrwldd
      541 iglpqykdqf hesrvdgrml qyltvndllf lkvtsqlhhl sikcaihvlh vnkfnphclh
      601 rrpadesnls psevvqwsnh rvmewlrsvd laeyapnlrg sgvhggliil eprftgdtla
      661 mllnippqkt llrrhlttkf naligpeaeq ekrekmaspa ytpltttakv rprklgfshf
      721 gnirkkkfde stdyicpmep sdgvsdshrv ysgyrglspl dapeldgldq mapsegtvtq
      781 igllsqdihr lttmlsqdql lndsrlpapn sddwr
//
LOCUS       XP_054226236             804 aa            linear   PRI 05-AUG-2025
DEFINITION  liprin-beta-2 isoform X10 [Homo sapiens].
ACCESSION   XP_054226236
VERSION     XP_054226236.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370261.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..804
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..804
                     /product="liprin-beta-2 isoform X10"
                     /calculated_mol_wt=90801
     Region          <1..>205
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          443..506
                     /region_name="SAM_liprin-beta1,2_repeat1"
                     /note="SAM domain of liprin-beta1,2 proteins repeat 1;
                     cd09563"
                     /db_xref="CDD:188962"
     Region          517..579
                     /region_name="SAM_liprin-beta1,2_repeat2"
                     /note="SAM domain of liprin-beta1,2 proteins repeat 2;
                     cd09566"
                     /db_xref="CDD:188965"
     Region          602..673
                     /region_name="SAM_liprin-beta1,2_repeat3"
                     /note="SAM domain of liprin-beta proteins repeat 3;
                     cd09569"
                     /db_xref="CDD:188968"
     CDS             1..804
                     /gene="PPFIBP2"
                     /gene_synonym="Cclp1"
                     /coded_by="XM_054370261.1:150..2564"
                     /db_xref="GeneID:8495"
                     /db_xref="HGNC:HGNC:9250"
                     /db_xref="MIM:603142"
ORIGIN      
        1 msseqwprlp gkvsvltdqv eaqgekirdl evcleghqvk lnaaeemlqq ellsrtslet
       61 qkldlmtevs elklklvgme keqreqeekq rkaeellqel rhlkikveel enernqyewk
      121 lkatkaevaq lqeqvalkda eierlhsqls rtaalhsesh terdqeiqrl kmgmetllla
      181 nedkdrriee ltgllnqyrk vkeivmvtqg psertlsine eepeggfskw natnkdpeel
      241 fkqempprcs sptvgppplp qksletraqk klscsledlr sesvdkcmdg nqpfpvlepk
      301 dspflaehky ptlpgklsga tpngeaaksp pticqpdatg ssllrlrdte sgwddtavvn
      361 dlsstssgte sgpqspltpd gkrnpkgikk fwgkirrtqs gnfytdtlgm aefrrgglra
      421 tagprlsrtr dskgqksdan apfaqwster vcawledfgl aqyvifarqw vssghtllta
      481 tpqdmekelg ikhplhrkkl vlavkaintk qeeksalldh iwvtrwlddi glpqykdqfh
      541 esrvdgrmlq yltvndllfl kvtsqlhhls ikcaihvlhv nkfnphclhr rpadesnlsp
      601 sevvqwsnhr vmewlrsvdl aeyapnlrgs gvhggliile prftgdtlam llnippqktl
      661 lrrhlttkfn aligpeaeqe krekmaspay tpltttakvr prklgfshfg nirkkkfdes
      721 tdyicpmeps dgvsdshrvy sgyrglspld apeldgldqm apsegtvtqi gllsqdihrl
      781 ttmlsqdqll ndsrlpapns ddwr
//
LOCUS       XP_054226237             784 aa            linear   PRI 05-AUG-2025
DEFINITION  liprin-beta-2 isoform X11 [Homo sapiens].
ACCESSION   XP_054226237
VERSION     XP_054226237.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370262.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..784
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..784
                     /product="liprin-beta-2 isoform X11"
                     /calculated_mol_wt=88532
     Region          <63..>175
                     /region_name="COG2433"
                     /note="Possible nuclease of RNase H fold, RuvC/YqgF family
                     [General function prediction only]"
                     /db_xref="CDD:441980"
     Region          423..486
                     /region_name="SAM_liprin-beta1,2_repeat1"
                     /note="SAM domain of liprin-beta1,2 proteins repeat 1;
                     cd09563"
                     /db_xref="CDD:188962"
     Region          497..559
                     /region_name="SAM_liprin-beta1,2_repeat2"
                     /note="SAM domain of liprin-beta1,2 proteins repeat 2;
                     cd09566"
                     /db_xref="CDD:188965"
     Region          582..653
                     /region_name="SAM_liprin-beta1,2_repeat3"
                     /note="SAM domain of liprin-beta proteins repeat 3;
                     cd09569"
                     /db_xref="CDD:188968"
     CDS             1..784
                     /gene="PPFIBP2"
                     /gene_synonym="Cclp1"
                     /coded_by="XM_054370262.1:226..2580"
                     /db_xref="GeneID:8495"
                     /db_xref="HGNC:HGNC:9250"
                     /db_xref="MIM:603142"
ORIGIN      
        1 mgklitrmwk llrrrsapke llsrtsletq kldlmtevse lklklvgmek eqreqeekqr
       61 kaeellqelr hlkikveele nernqyewkl katkaevaql qeqvalkdae ierlhsqlsr
      121 taalhsesht erdqeiqrlk mgmetlllan edkdrrieel tgllnqyrkv keivmvtqgp
      181 sertlsinee epeggfskwn atnkdpeelf kqempprcss ptvgppplpq ksletraqkk
      241 lscsledlrs esvdkcmdgn qpfpvlepkd spflaehkyp tlpgklsgat pngeaakspp
      301 ticqpdatgs sllrlnrgrs vsapvlgdte sgwddtavvn dlsstssgte sgpqspltpd
      361 gkrnpkgikk fwgkirrtqs gnfytdtlgm aefrrgglra tagprlsrtr dskgqksdan
      421 apfaqwster vcawledfgl aqyvifarqw vssghtllta tpqdmekelg ikhplhrkkl
      481 vlavkaintk qeeksalldh iwvtrwlddi glpqykdqfh esrvdgrmlq yltvndllfl
      541 kvtsqlhhls ikcaihvlhv nkfnphclhr rpadesnlsp sevvqwsnhr vmewlrsvdl
      601 aeyapnlrgs gvhggliile prftgdtlam llnippqktl lrrhlttkfn aligpeaeqe
      661 krekmaspay tpltttakvr prklgfshfg nirkkkfdes tdyicpmeps dgvsdshrvy
      721 sgyrglspld apeldgldqm apsegtvtqi gllsqdihrl ttmlsqdqll ndsrlpapns
      781 ddwr
//
LOCUS       XP_054226238             773 aa            linear   PRI 05-AUG-2025
DEFINITION  liprin-beta-2 isoform X12 [Homo sapiens].
ACCESSION   XP_054226238
VERSION     XP_054226238.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370263.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..773
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..773
                     /product="liprin-beta-2 isoform X12"
                     /calculated_mol_wt=87494
     Region          <63..>175
                     /region_name="COG2433"
                     /note="Possible nuclease of RNase H fold, RuvC/YqgF family
                     [General function prediction only]"
                     /db_xref="CDD:441980"
     Region          412..475
                     /region_name="SAM_liprin-beta1,2_repeat1"
                     /note="SAM domain of liprin-beta1,2 proteins repeat 1;
                     cd09563"
                     /db_xref="CDD:188962"
     Region          486..548
                     /region_name="SAM_liprin-beta1,2_repeat2"
                     /note="SAM domain of liprin-beta1,2 proteins repeat 2;
                     cd09566"
                     /db_xref="CDD:188965"
     Region          571..642
                     /region_name="SAM_liprin-beta1,2_repeat3"
                     /note="SAM domain of liprin-beta proteins repeat 3;
                     cd09569"
                     /db_xref="CDD:188968"
     CDS             1..773
                     /gene="PPFIBP2"
                     /gene_synonym="Cclp1"
                     /coded_by="XM_054370263.1:226..2547"
                     /db_xref="GeneID:8495"
                     /db_xref="HGNC:HGNC:9250"
                     /db_xref="MIM:603142"
ORIGIN      
        1 mgklitrmwk llrrrsapke llsrtsletq kldlmtevse lklklvgmek eqreqeekqr
       61 kaeellqelr hlkikveele nernqyewkl katkaevaql qeqvalkdae ierlhsqlsr
      121 taalhsesht erdqeiqrlk mgmetlllan edkdrrieel tgllnqyrkv keivmvtqgp
      181 sertlsinee epeggfskwn atnkdpeelf kqempprcss ptvgppplpq ksletraqkk
      241 lscsledlrs esvdkcmdgn qpfpvlepkd spflaehkyp tlpgklsgat pngeaakspp
      301 ticqpdatgs sllrlrdtes gwddtavvnd lsstssgtes gpqspltpdg krnpkgikkf
      361 wgkirrtqsg nfytdtlgma efrrgglrat agprlsrtrd skgqksdana pfaqwsterv
      421 cawledfgla qyvifarqwv ssghtlltat pqdmekelgi khplhrkklv lavkaintkq
      481 eeksalldhi wvtrwlddig lpqykdqfhe srvdgrmlqy ltvndllflk vtsqlhhlsi
      541 kcaihvlhvn kfnphclhrr padesnlsps evvqwsnhrv mewlrsvdla eyapnlrgsg
      601 vhggliilep rftgdtlaml lnippqktll rrhlttkfna ligpeaeqek rekmaspayt
      661 pltttakvrp rklgfshfgn irkkkfdest dyicpmepsd gvsdshrvys gyrglsplda
      721 peldgldqma psegtvtqig llsqdihrlt tmlsqdqlln dsrlpapnsd dwr
//
LOCUS       XP_054226239             770 aa            linear   PRI 05-AUG-2025
DEFINITION  liprin-beta-2 isoform X13 [Homo sapiens].
ACCESSION   XP_054226239
VERSION     XP_054226239.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370264.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..770
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..770
                     /product="liprin-beta-2 isoform X13"
                     /calculated_mol_wt=86494
     Region          <50..>161
                     /region_name="COG2433"
                     /note="Possible nuclease of RNase H fold, RuvC/YqgF family
                     [General function prediction only]"
                     /db_xref="CDD:441980"
     Region          409..472
                     /region_name="SAM_liprin-beta1,2_repeat1"
                     /note="SAM domain of liprin-beta1,2 proteins repeat 1;
                     cd09563"
                     /db_xref="CDD:188962"
     Region          483..545
                     /region_name="SAM_liprin-beta1,2_repeat2"
                     /note="SAM domain of liprin-beta1,2 proteins repeat 2;
                     cd09566"
                     /db_xref="CDD:188965"
     Region          568..639
                     /region_name="SAM_liprin-beta1,2_repeat3"
                     /note="SAM domain of liprin-beta proteins repeat 3;
                     cd09569"
                     /db_xref="CDD:188968"
     CDS             1..770
                     /gene="PPFIBP2"
                     /gene_synonym="Cclp1"
                     /coded_by="XM_054370264.1:6720..9032"
                     /db_xref="GeneID:8495"
                     /db_xref="HGNC:HGNC:9250"
                     /db_xref="MIM:603142"
ORIGIN      
        1 mcrlqldihr qiqerlllsr dhpeevaasd gvaepqpcsq dcacwegspe llqelrhlki
       61 kveelenern qyewklkatk aevaqlqeqv alkdaeierl hsqlsrtaal hseshterdq
      121 eiqrlkmgme tlllanedkd rrieeltgll nqyrkvkeiv mvtqgpsert lsineeepeg
      181 gfskwnatnk dpeelfkqem pprcssptvg ppplpqksle traqkklscs ledlrsesvd
      241 kcmdgnqpfp vlepkdspfl aehkyptlpg klsgatpnge aaksppticq pdatgssllr
      301 lnrgrsvsap vlgdtesgwd dtavvndlss tssgtesgpq spltpdgkrn pkgikkfwgk
      361 irrtqsgnfy tdtlgmaefr rgglratagp rlsrtrdskg qksdanapfa qwstervcaw
      421 ledfglaqyv ifarqwvssg htlltatpqd mekelgikhp lhrkklvlav kaintkqeek
      481 salldhiwvt rwlddiglpq ykdqfhesrv dgrmlqyltv ndllflkvts qlhhlsikca
      541 ihvlhvnkfn phclhrrpad esnlspsevv qwsnhrvmew lrsvdlaeya pnlrgsgvhg
      601 gliileprft gdtlamllni ppqktllrrh lttkfnalig peaeqekrek maspaytplt
      661 ttakvrprkl gfshfgnirk kkfdestdyi cpmepsdgvs dshrvysgyr glspldapel
      721 dgldqmapse gtvtqiglls qdihrlttml sqdqllndsr lpapnsddwr
//
LOCUS       XP_054226240             301 aa            linear   PRI 05-AUG-2025
DEFINITION  tumor necrosis factor receptor superfamily member 19L isoform X1
            [Homo sapiens].
ACCESSION   XP_054226240
VERSION     XP_054226240.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370265.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..301
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..301
                     /product="tumor necrosis factor receptor superfamily
                     member 19L isoform X1"
                     /calculated_mol_wt=31535
     Region          27..112
                     /region_name="TNFRSF19L"
                     /note="tumor necrosis factor receptor superfamily member
                     19-like (TNFRSF19L), also known as receptor expressed in
                     lymphoid tissues (RELT); cd13419"
                     /db_xref="CDD:276924"
     Region          27..48
                     /region_name="CRD1"
                     /note="CRD1 [structural motif]"
                     /db_xref="CDD:276924"
     Region          51..90
                     /region_name="CRD2"
                     /note="CRD2 [structural motif]"
                     /db_xref="CDD:276924"
     Region          163..198
                     /region_name="RELT"
                     /note="Tumour necrosis factor receptor superfamily member
                     19; pfam12606"
                     /db_xref="CDD:403713"
     CDS             1..301
                     /gene="RELT"
                     /gene_synonym="AI3C; TNFRSF19L; TRLT"
                     /coded_by="XM_054370265.1:228..1133"
                     /db_xref="GeneID:84957"
                     /db_xref="HGNC:HGNC:13764"
                     /db_xref="MIM:611211"
ORIGIN      
        1 mkpsllcrpl scflmllpwp latltsttlw qcppgeepdl dpgqgtlcrp cppgtfsaaw
       61 gsspcqphar cslwrrleaq vgmatrdtlc gdcwpgwfgp wgvprvpcqp cswaplgthg
      121 cdewgrrarr gvevaagass ggetrqpgng traggpeeta aqyaviaivp vfclmgllgi
      181 lvcnllkrkg yhctahkevg pgpggggsgi npayrtedan edtigvlvrl itekkathre
      241 ccgpggaaer vpqqtagade pqacvqaaas aperathlpa pppsphragp glalwplllp
      301 l
//
LOCUS       XP_054226242             336 aa            linear   PRI 05-AUG-2025
DEFINITION  tumor necrosis factor receptor superfamily member 19L isoform X3
            [Homo sapiens].
ACCESSION   XP_054226242
VERSION     XP_054226242.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370267.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..336
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..336
                     /product="tumor necrosis factor receptor superfamily
                     member 19L isoform X3"
                     /calculated_mol_wt=35776
     Region          69..104
                     /region_name="RELT"
                     /note="Tumour necrosis factor receptor superfamily member
                     19; pfam12606"
                     /db_xref="CDD:403713"
     CDS             1..336
                     /gene="RELT"
                     /gene_synonym="AI3C; TNFRSF19L; TRLT"
                     /coded_by="XM_054370267.1:1519..2529"
                     /db_xref="GeneID:84957"
                     /db_xref="HGNC:HGNC:13764"
                     /db_xref="MIM:611211"
ORIGIN      
        1 mpvaafgggw rprwawqlei hsvetaglew grrarrgvev aagassgget rqpgngtrag
       61 gpeetaaqya viaivpvfcl mgllgilvcn llkrkgyhct ahkevgpgpg gggsginpay
      121 rtedanedti gvlvrlitek kenaaaleel lkeyhskqlv qtshrpvskl ppappnvphi
      181 cphrhhlhtv qglaslsgpc csrcsqkkwp evllspeava attpvpsllp nptrvpkaga
      241 kagrqgeiti lsvgrfrvar ipeqrtssmv sevktiteag pswgdlpdsp qpglppeqqa
      301 llgsggsrtk wlkppaenka eenryvvrls esnlvi
//
LOCUS       XP_054226243             250 aa            linear   PRI 05-AUG-2025
DEFINITION  tumor necrosis factor receptor superfamily member 19L isoform X4
            [Homo sapiens].
ACCESSION   XP_054226243
VERSION     XP_054226243.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370268.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..250
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..250
                     /product="tumor necrosis factor receptor superfamily
                     member 19L isoform X4"
                     /calculated_mol_wt=27063
     CDS             1..250
                     /gene="RELT"
                     /gene_synonym="AI3C; TNFRSF19L; TRLT"
                     /coded_by="XM_054370268.1:1518..2270"
                     /db_xref="GeneID:84957"
                     /db_xref="HGNC:HGNC:13764"
                     /db_xref="MIM:611211"
ORIGIN      
        1 mpvaafgggw rprwawqlei hsvetaglgi npayrtedan edtigvlvrl itekkenaaa
       61 leellkeyhs kqlvqtshrp vsklppappn vphicphrhh lhtvqglasl sgpccsrcsq
      121 kkwpevllsp eavaattpvp sllpnptrvp kagakagrqg eitilsvgrf rvaripeqrt
      181 ssmvsevkti teagpswgdl pdspqpglpp eqqallgsgg srtkwlkppa enkaeenryv
      241 vrlsesnlvi
//
LOCUS       XP_054226244             238 aa            linear   PRI 05-AUG-2025
DEFINITION  tumor necrosis factor receptor superfamily member 19L isoform X5
            [Homo sapiens].
ACCESSION   XP_054226244
VERSION     XP_054226244.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370269.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..238
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..238
                     /product="tumor necrosis factor receptor superfamily
                     member 19L isoform X5"
                     /calculated_mol_wt=25803
     CDS             1..238
                     /gene="RELT"
                     /gene_synonym="AI3C; TNFRSF19L; TRLT"
                     /coded_by="XM_054370269.1:1197..1913"
                     /db_xref="GeneID:84957"
                     /db_xref="HGNC:HGNC:13764"
                     /db_xref="MIM:611211"
ORIGIN      
        1 mhpgcwvqea lvlnheginp ayrtedaned tigvlvrlit ekkenaaale ellkeyhskq
       61 lvqtshrpvs klppappnvp hicphrhhlh tvqglaslsg pccsrcsqkk wpevllspea
      121 vaattpvpsl lpnptrvpka gakagrqgei tilsvgrfrv aripeqrtss mvsevktite
      181 agpswgdlpd spqpglppeq qallgsggsr tkwlkppaen kaeenryvvr lsesnlvi
//
LOCUS       XP_054226245             677 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin-associated and SH3 domain-containing protein B isoform X1
            [Homo sapiens].
ACCESSION   XP_054226245
VERSION     XP_054226245.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370270.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..677
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..677
                     /product="ubiquitin-associated and SH3 domain-containing
                     protein B isoform X1"
                     /calculated_mol_wt=75400
     Region          <83..104
                     /region_name="UBA_like_SF"
                     /note="UBA domain-like superfamily; cl21463"
                     /db_xref="CDD:473871"
     Region          284..345
                     /region_name="SH3_UBASH3B"
                     /note="Src homology 3 domain of Ubiquitin-associated and
                     SH3 domain-containing protein B; cd11936"
                     /db_xref="CDD:212869"
     Site            order(291,293,296,300,322..323,338,340..341)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212869"
     Region          414..626
                     /region_name="HP_PGM_like"
                     /note="Histidine phosphatase domain found in
                     phosphoglycerate mutases and related proteins, mostly
                     phosphatases; contains a His residue which is
                     phosphorylated during the reaction; cd07067"
                     /db_xref="CDD:132718"
     Site            order(418..419,501,604..605)
                     /site_type="active"
                     /note="catalytic core [active]"
                     /db_xref="CDD:132718"
     CDS             1..677
                     /gene="UBASH3B"
                     /gene_synonym="p70; STS-1; STS1; TULA-2; TULA2"
                     /coded_by="XM_054370270.1:6435..8468"
                     /db_xref="GeneID:84959"
                     /db_xref="HGNC:HGNC:29884"
                     /db_xref="MIM:609201"
ORIGIN      
        1 micvvlcihg fctekkkarc vasdclvsre etdkaatqqq lstlskcgne rvwvsvlpaf
       61 sapavpsgae gsvlllrnfi nlqkalastg grsvqaacdw lfshvgdpfl ddplpreyvl
      121 ylrptgplaq klsdfwqqsk qicgknkahn ifphitlcqf fmcedskvda lgealqttvs
      181 rwkckfsapl plelytssnf iglfvkedsa evlkkfaadf aaeaasktev hvephkkqlh
      241 vtlayhfqas hlptleklaq nidvklgcdw vatifsrdir fanhetlqvi ypytpqndde
      301 lelvpgdfif mspmeqtsts egwiygtslt tgcsgllpen yitkadecst wifhgsysil
      361 ntsssnsltf gdgvlerrpy edqglgettp ltiicqpmqp lrvnsqpgpq krclfvcrhg
      421 ermdvvfgky wlsqcfdakg ryirtnlnmp hslpqrsggf rdyekdapit vfgcmqarlv
      481 geallesnti idhvycspsl rcvqtahnil kglqqenhlk irvepglfew tkwvagstlp
      541 awippselaa anlsvdttyr phipisklvv sesydtyisr sfqvtkeiis eckskgnnil
      601 ivahasslea ctcqlqglsp qnskdfvqmv rkipylgfcs ceelgetgiw qltdppilpl
      661 thgptggfnw retllqe
//
LOCUS       XP_054226246             630 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin-associated and SH3 domain-containing protein B isoform X2
            [Homo sapiens].
ACCESSION   XP_054226246
VERSION     XP_054226246.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370271.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..630
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..630
                     /product="ubiquitin-associated and SH3 domain-containing
                     protein B isoform X2"
                     /calculated_mol_wt=70960
     Region          237..298
                     /region_name="SH3_UBASH3B"
                     /note="Src homology 3 domain of Ubiquitin-associated and
                     SH3 domain-containing protein B; cd11936"
                     /db_xref="CDD:212869"
     Site            order(244,246,249,253,275..276,291,293..294)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212869"
     Region          367..579
                     /region_name="HP_PGM_like"
                     /note="Histidine phosphatase domain found in
                     phosphoglycerate mutases and related proteins, mostly
                     phosphatases; contains a His residue which is
                     phosphorylated during the reaction; cd07067"
                     /db_xref="CDD:132718"
     Site            order(371..372,454,557..558)
                     /site_type="active"
                     /note="catalytic core [active]"
                     /db_xref="CDD:132718"
     CDS             1..630
                     /gene="UBASH3B"
                     /gene_synonym="p70; STS-1; STS1; TULA-2; TULA2"
                     /coded_by="XM_054370271.1:71..1963"
                     /db_xref="GeneID:84959"
                     /db_xref="HGNC:HGNC:29884"
                     /db_xref="MIM:609201"
ORIGIN      
        1 msvcgslcfq pflhqlfqae qrglscfsvt sstykkpwhp reeevfrqhv tgwlfshvgd
       61 pflddplpre yvlylrptgp laqklsdfwq qskqicgknk ahnifphitl cqffmcedsk
      121 vdalgealqt tvsrwkckfs aplplelyts snfiglfvke dsaevlkkfa adfaaeaask
      181 tevhvephkk qlhvtlayhf qashlptlek laqnidvklg cdwvatifsr dirfanhetl
      241 qviypytpqn ddelelvpgd fifmspmeqt stsegwiygt slttgcsgll penyitkade
      301 cstwifhgsy silntsssns ltfgdgvler rpyedqglge ttpltiicqp mqplrvnsqp
      361 gpqkrclfvc rhgermdvvf gkywlsqcfd akgryirtnl nmphslpqrs ggfrdyekda
      421 pitvfgcmqa rlvgealles ntiidhvycs pslrcvqtah nilkglqqen hlkirvepgl
      481 fewtkwvags tlpawippse laaanlsvdt tyrphipisk lvvsesydty isrsfqvtke
      541 iiseckskgn nilivahass leactcqlqg lspqnskdfv qmvrkipylg fcsceelget
      601 giwqltdppi lplthgptgg fnwretllqe
//
LOCUS       XP_054226247            1306 aa            linear   PRI 05-AUG-2025
DEFINITION  liprin-alpha-1 isoform X1 [Homo sapiens].
ACCESSION   XP_054226247
VERSION     XP_054226247.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370272.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 34% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1306
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1306
                     /product="liprin-alpha-1 isoform X1"
                     /calculated_mol_wt=146960
     Region          <45..687
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          <266..>548
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          949..1019
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat1"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     1; cd09562"
                     /db_xref="CDD:188961"
     Region          1066..1131
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat2"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     2; cd09565"
                     /db_xref="CDD:188964"
     Region          1151..1222
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat3"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     3; cd09568"
                     /db_xref="CDD:188967"
     CDS             1..1306
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /coded_by="XM_054370272.1:226..4146"
                     /db_xref="GeneID:8500"
                     /db_xref="HGNC:HGNC:9245"
                     /db_xref="MIM:611054"
ORIGIN      
        1 mmcevmptis eaegppgggg ghgsgspsqp dadshfeqlm vsmleerdrl ldtlretqet
       61 laltqgklhe vgherdslqr qlntalpqef aaltkelnvc reqllereee iaelkaernn
      121 trlllehlec lvsrherslr mtvvkrqaqs pagvssevev lkalkslfeh hkaldekvre
      181 rlrvalercs lleeelgath kelmilkeqn nqkktltdgv ldinheqent pstsgkrssd
      241 gslsheedla kvielqeiis kqsreqsqmk erlaslsshv teleedldta rkdlikseem
      301 ntklqrdvre amaqkedmee rittlekryl aaqreatsvh dlndklenei ankdsmhrqt
      361 edknrqlqer lelaeqklqq tlrkaetlpe veaelaqrva alsksdllss gssaakeakl
      421 leltsklrka eerhgnieer lrqmeaqlee knqelqrarq rekmneehnk rlsdtvdkll
      481 sesnerlqlh lkermaaled knsllreves akkqleetqh dkdqlvlnie alraeldhmr
      541 lrgaslhhgr phlgsvpdfr fpmadghtds ystsavlrrp qkgrlaalrd epskvqtlne
      601 qdweraqqas vlanvaqafe sdadvsdged drdtllssvd llspsgqada htlammlqeq
      661 ldainkeirl iqeekenteq raeeiesrvg sgsldnlgrf rsmssippyp asslassspp
      721 gsgrstprri phsparevdr lgvmtlpspd sfliqtsgph qsvvysstsp psstpcysds
      781 sqhaqpsdlr khrrklppsr eevrddktti kcetsppssp ralrldrlhk galhtvshed
      841 irdirnstgs qdgpvsnpss snssqdslhk apkkkgikss igrlfgkkek grpgqtgkea
      901 lgqagvsetd nssqdalgls klggqaeknr klqkkhelle earrqglpfa qwdgptvvvw
      961 lelwvgmpaw yvaacranvk sgaimsalsd teiqreigis nplhrlklrl aiqeimslts
     1021 psapptsrtt tgnvwlthee metlaatpqt edeegswaqt laygdmnhew ignewlpslg
     1081 lpqyrsyfme clvdarmldh ltkkdlrgql kmvdsfhrns fqcgimclrr lnydrkeler
     1141 kreesqseik dvlvwsndrv irwilsiglk eyannliesg vhgallalde tfdfsalall
     1201 lqiptqntqa ravlerefnn llvmgtdrrf dedddksfrr apswrkkfrp kdirglaags
     1261 aetlpanfrv tssmsspsmq pkkmqmdgnv sgtqrldsat vrtysc
//
LOCUS       XP_054226248            1306 aa            linear   PRI 05-AUG-2025
DEFINITION  liprin-alpha-1 isoform X1 [Homo sapiens].
ACCESSION   XP_054226248
VERSION     XP_054226248.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370273.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 34% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1306
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1306
                     /product="liprin-alpha-1 isoform X1"
                     /calculated_mol_wt=146960
     Region          <45..687
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          <266..>548
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          949..1019
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat1"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     1; cd09562"
                     /db_xref="CDD:188961"
     Region          1066..1131
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat2"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     2; cd09565"
                     /db_xref="CDD:188964"
     Region          1151..1222
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat3"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     3; cd09568"
                     /db_xref="CDD:188967"
     CDS             1..1306
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /coded_by="XM_054370273.1:128..4048"
                     /db_xref="GeneID:8500"
                     /db_xref="HGNC:HGNC:9245"
                     /db_xref="MIM:611054"
ORIGIN      
        1 mmcevmptis eaegppgggg ghgsgspsqp dadshfeqlm vsmleerdrl ldtlretqet
       61 laltqgklhe vgherdslqr qlntalpqef aaltkelnvc reqllereee iaelkaernn
      121 trlllehlec lvsrherslr mtvvkrqaqs pagvssevev lkalkslfeh hkaldekvre
      181 rlrvalercs lleeelgath kelmilkeqn nqkktltdgv ldinheqent pstsgkrssd
      241 gslsheedla kvielqeiis kqsreqsqmk erlaslsshv teleedldta rkdlikseem
      301 ntklqrdvre amaqkedmee rittlekryl aaqreatsvh dlndklenei ankdsmhrqt
      361 edknrqlqer lelaeqklqq tlrkaetlpe veaelaqrva alsksdllss gssaakeakl
      421 leltsklrka eerhgnieer lrqmeaqlee knqelqrarq rekmneehnk rlsdtvdkll
      481 sesnerlqlh lkermaaled knsllreves akkqleetqh dkdqlvlnie alraeldhmr
      541 lrgaslhhgr phlgsvpdfr fpmadghtds ystsavlrrp qkgrlaalrd epskvqtlne
      601 qdweraqqas vlanvaqafe sdadvsdged drdtllssvd llspsgqada htlammlqeq
      661 ldainkeirl iqeekenteq raeeiesrvg sgsldnlgrf rsmssippyp asslassspp
      721 gsgrstprri phsparevdr lgvmtlpspd sfliqtsgph qsvvysstsp psstpcysds
      781 sqhaqpsdlr khrrklppsr eevrddktti kcetsppssp ralrldrlhk galhtvshed
      841 irdirnstgs qdgpvsnpss snssqdslhk apkkkgikss igrlfgkkek grpgqtgkea
      901 lgqagvsetd nssqdalgls klggqaeknr klqkkhelle earrqglpfa qwdgptvvvw
      961 lelwvgmpaw yvaacranvk sgaimsalsd teiqreigis nplhrlklrl aiqeimslts
     1021 psapptsrtt tgnvwlthee metlaatpqt edeegswaqt laygdmnhew ignewlpslg
     1081 lpqyrsyfme clvdarmldh ltkkdlrgql kmvdsfhrns fqcgimclrr lnydrkeler
     1141 kreesqseik dvlvwsndrv irwilsiglk eyannliesg vhgallalde tfdfsalall
     1201 lqiptqntqa ravlerefnn llvmgtdrrf dedddksfrr apswrkkfrp kdirglaags
     1261 aetlpanfrv tssmsspsmq pkkmqmdgnv sgtqrldsat vrtysc
//
LOCUS       XP_054226249            1297 aa            linear   PRI 05-AUG-2025
DEFINITION  liprin-alpha-1 isoform X2 [Homo sapiens].
ACCESSION   XP_054226249
VERSION     XP_054226249.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370274.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 34% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1297
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1297
                     /product="liprin-alpha-1 isoform X2"
                     /calculated_mol_wt=145928
     Region          <45..687
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          <266..>548
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          949..1019
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat1"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     1; cd09562"
                     /db_xref="CDD:188961"
     Region          1057..1122
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat2"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     2; cd09565"
                     /db_xref="CDD:188964"
     Region          1142..1213
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat3"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     3; cd09568"
                     /db_xref="CDD:188967"
     CDS             1..1297
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /coded_by="XM_054370274.1:226..4119"
                     /db_xref="GeneID:8500"
                     /db_xref="HGNC:HGNC:9245"
                     /db_xref="MIM:611054"
ORIGIN      
        1 mmcevmptis eaegppgggg ghgsgspsqp dadshfeqlm vsmleerdrl ldtlretqet
       61 laltqgklhe vgherdslqr qlntalpqef aaltkelnvc reqllereee iaelkaernn
      121 trlllehlec lvsrherslr mtvvkrqaqs pagvssevev lkalkslfeh hkaldekvre
      181 rlrvalercs lleeelgath kelmilkeqn nqkktltdgv ldinheqent pstsgkrssd
      241 gslsheedla kvielqeiis kqsreqsqmk erlaslsshv teleedldta rkdlikseem
      301 ntklqrdvre amaqkedmee rittlekryl aaqreatsvh dlndklenei ankdsmhrqt
      361 edknrqlqer lelaeqklqq tlrkaetlpe veaelaqrva alsksdllss gssaakeakl
      421 leltsklrka eerhgnieer lrqmeaqlee knqelqrarq rekmneehnk rlsdtvdkll
      481 sesnerlqlh lkermaaled knsllreves akkqleetqh dkdqlvlnie alraeldhmr
      541 lrgaslhhgr phlgsvpdfr fpmadghtds ystsavlrrp qkgrlaalrd epskvqtlne
      601 qdweraqqas vlanvaqafe sdadvsdged drdtllssvd llspsgqada htlammlqeq
      661 ldainkeirl iqeekenteq raeeiesrvg sgsldnlgrf rsmssippyp asslassspp
      721 gsgrstprri phsparevdr lgvmtlpspd sfliqtsgph qsvvysstsp psstpcysds
      781 sqhaqpsdlr khrrklppsr eevrddktti kcetsppssp ralrldrlhk galhtvshed
      841 irdirnstgs qdgpvsnpss snssqdslhk apkkkgikss igrlfgkkek grpgqtgkea
      901 lgqagvsetd nssqdalgls klggqaeknr klqkkhelle earrqglpfa qwdgptvvvw
      961 lelwvgmpaw yvaacranvk sgaimsalsd teiqreigis nplhrlklrl aiqeimslts
     1021 psapptsrtt tgnvwlthee metlaatpqt tlaygdmnhe wignewlpsl glpqyrsyfm
     1081 eclvdarmld hltkkdlrgq lkmvdsfhrn sfqcgimclr rlnydrkele rkreesqsei
     1141 kdvlvwsndr virwilsigl keyannlies gvhgallald etfdfsalal llqiptqntq
     1201 aravlerefn nllvmgtdrr fdedddksfr rapswrkkfr pkdirglaag saetlpanfr
     1261 vtssmsspsm qpkkmqmdgn vsgtqrldsa tvrtysc
//
LOCUS       XP_054226250            1296 aa            linear   PRI 05-AUG-2025
DEFINITION  liprin-alpha-1 isoform X3 [Homo sapiens].
ACCESSION   XP_054226250
VERSION     XP_054226250.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370275.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 34% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1296
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1296
                     /product="liprin-alpha-1 isoform X3"
                     /calculated_mol_wt=145685
     Region          <45..687
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          <266..>548
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          939..1009
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat1"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     1; cd09562"
                     /db_xref="CDD:188961"
     Region          1056..1121
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat2"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     2; cd09565"
                     /db_xref="CDD:188964"
     Region          1141..1212
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat3"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     3; cd09568"
                     /db_xref="CDD:188967"
     CDS             1..1296
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /coded_by="XM_054370275.1:226..4116"
                     /db_xref="GeneID:8500"
                     /db_xref="HGNC:HGNC:9245"
                     /db_xref="MIM:611054"
ORIGIN      
        1 mmcevmptis eaegppgggg ghgsgspsqp dadshfeqlm vsmleerdrl ldtlretqet
       61 laltqgklhe vgherdslqr qlntalpqef aaltkelnvc reqllereee iaelkaernn
      121 trlllehlec lvsrherslr mtvvkrqaqs pagvssevev lkalkslfeh hkaldekvre
      181 rlrvalercs lleeelgath kelmilkeqn nqkktltdgv ldinheqent pstsgkrssd
      241 gslsheedla kvielqeiis kqsreqsqmk erlaslsshv teleedldta rkdlikseem
      301 ntklqrdvre amaqkedmee rittlekryl aaqreatsvh dlndklenei ankdsmhrqt
      361 edknrqlqer lelaeqklqq tlrkaetlpe veaelaqrva alsksdllss gssaakeakl
      421 leltsklrka eerhgnieer lrqmeaqlee knqelqrarq rekmneehnk rlsdtvdkll
      481 sesnerlqlh lkermaaled knsllreves akkqleetqh dkdqlvlnie alraeldhmr
      541 lrgaslhhgr phlgsvpdfr fpmadghtds ystsavlrrp qkgrlaalrd epskvqtlne
      601 qdweraqqas vlanvaqafe sdadvsdged drdtllssvd llspsgqada htlammlqeq
      661 ldainkeirl iqeekenteq raeeiesrvg sgsldnlgrf rsmssippyp asslassspp
      721 gsgrstprri phsparevdr lgvmtlpspd sfliqtsgph qsvvysstsp psstpcysds
      781 sqhaqlppsr eevrddktti kcetsppssp ralrldrlhk galhtvshed irdirnstgs
      841 qdgpvsnpss snssqdslhk apkkkgikss igrlfgkkek grpgqtgkea lgqagvsetd
      901 nssqdalgls klggqaeknr klqkkhelle earrqglpfa qwdgptvvvw lelwvgmpaw
      961 yvaacranvk sgaimsalsd teiqreigis nplhrlklrl aiqeimslts psapptsrtt
     1021 tgnvwlthee metlaatpqt edeegswaqt laygdmnhew ignewlpslg lpqyrsyfme
     1081 clvdarmldh ltkkdlrgql kmvdsfhrns fqcgimclrr lnydrkeler kreesqseik
     1141 dvlvwsndrv irwilsiglk eyannliesg vhgallalde tfdfsalall lqiptqntqa
     1201 ravlerefnn llvmgtdrrf dedddksfrr apswrkkfrp kdirglaags aetlpanfrv
     1261 tssmsspsmq pkkmqmdgnv sgtqrldsat vrtysc
//
LOCUS       XP_054226251            1295 aa            linear   PRI 05-AUG-2025
DEFINITION  liprin-alpha-1 isoform X4 [Homo sapiens].
ACCESSION   XP_054226251
VERSION     XP_054226251.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370276.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1295
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1295
                     /product="liprin-alpha-1 isoform X4"
                     /calculated_mol_wt=146089
     Region          <45..687
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          <266..>548
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          949..1019
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat1"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     1; cd09562"
                     /db_xref="CDD:188961"
     Region          1066..1131
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat2"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     2; cd09565"
                     /db_xref="CDD:188964"
     Region          1151..1222
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat3"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     3; cd09568"
                     /db_xref="CDD:188967"
     CDS             1..1295
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /coded_by="XM_054370276.1:226..4113"
                     /db_xref="GeneID:8500"
                     /db_xref="HGNC:HGNC:9245"
                     /db_xref="MIM:611054"
ORIGIN      
        1 mmcevmptis eaegppgggg ghgsgspsqp dadshfeqlm vsmleerdrl ldtlretqet
       61 laltqgklhe vgherdslqr qlntalpqef aaltkelnvc reqllereee iaelkaernn
      121 trlllehlec lvsrherslr mtvvkrqaqs pagvssevev lkalkslfeh hkaldekvre
      181 rlrvalercs lleeelgath kelmilkeqn nqkktltdgv ldinheqent pstsgkrssd
      241 gslsheedla kvielqeiis kqsreqsqmk erlaslsshv teleedldta rkdlikseem
      301 ntklqrdvre amaqkedmee rittlekryl aaqreatsvh dlndklenei ankdsmhrqt
      361 edknrqlqer lelaeqklqq tlrkaetlpe veaelaqrva alsksdllss gssaakeakl
      421 leltsklrka eerhgnieer lrqmeaqlee knqelqrarq rekmneehnk rlsdtvdkll
      481 sesnerlqlh lkermaaled knsllreves akkqleetqh dkdqlvlnie alraeldhmr
      541 lrgaslhhgr phlgsvpdfr fpmadghtds ystsavlrrp qkgrlaalrd epskvqtlne
      601 qdweraqqas vlanvaqafe sdadvsdged drdtllssvd llspsgqada htlammlqeq
      661 ldainkeirl iqeekenteq raeeiesrvg sgsldnlgrf rsmssippyp asslassspp
      721 gsgrstprri phsparevdr lgvmtlpspd sfliqtsgph qsvvysstsp psstpcysds
      781 sqhaqpsdlr khrrklppsr eevrddktti kcetsppssp ralrldrlhk galhtvshed
      841 irdirnstgs qdgpvsnpss snssqdslhk apkkkgikss igrlfgkkek grpgqtgkea
      901 lgqagvsetd nssqdalgls klggqaeknr klqkkhelle earrqglpfa qwdgptvvvw
      961 lelwvgmpaw yvaacranvk sgaimsalsd teiqreigis nplhrlklrl aiqeimslts
     1021 psapptsrtt tgnvwlthee metlaatpqt edeegswaqt laygdmnhew ignewlpslg
     1081 lpqyrsyfme clvdarmldh ltkkdlrgql kmvdsfhrns fqcgimclrr lnydrkeler
     1141 kreesqseik dvlvwsndrv irwilsiglk eyannliesg vhgallalde tfdfsalall
     1201 lqiptqntqa ravlerefnn llvmgtdrrf dedddksfrr apswrkkfrp kdirglaags
     1261 aetlpanfrv tssmsspsmq pkkmqmdvyp hyfyr
//
LOCUS       XP_054226252            1289 aa            linear   PRI 05-AUG-2025
DEFINITION  liprin-alpha-1 isoform X5 [Homo sapiens].
ACCESSION   XP_054226252
VERSION     XP_054226252.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370277.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1289
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1289
                     /product="liprin-alpha-1 isoform X5"
                     /calculated_mol_wt=145151
     Region          <45..687
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          <266..>548
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          949..1019
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat1"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     1; cd09562"
                     /db_xref="CDD:188961"
     Region          1066..1131
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat2"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     2; cd09565"
                     /db_xref="CDD:188964"
     Region          1151..1222
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat3"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     3; cd09568"
                     /db_xref="CDD:188967"
     CDS             1..1289
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /coded_by="XM_054370277.1:226..4095"
                     /db_xref="GeneID:8500"
                     /db_xref="HGNC:HGNC:9245"
                     /db_xref="MIM:611054"
ORIGIN      
        1 mmcevmptis eaegppgggg ghgsgspsqp dadshfeqlm vsmleerdrl ldtlretqet
       61 laltqgklhe vgherdslqr qlntalpqef aaltkelnvc reqllereee iaelkaernn
      121 trlllehlec lvsrherslr mtvvkrqaqs pagvssevev lkalkslfeh hkaldekvre
      181 rlrvalercs lleeelgath kelmilkeqn nqkktltdgv ldinheqent pstsgkrssd
      241 gslsheedla kvielqeiis kqsreqsqmk erlaslsshv teleedldta rkdlikseem
      301 ntklqrdvre amaqkedmee rittlekryl aaqreatsvh dlndklenei ankdsmhrqt
      361 edknrqlqer lelaeqklqq tlrkaetlpe veaelaqrva alsksdllss gssaakeakl
      421 leltsklrka eerhgnieer lrqmeaqlee knqelqrarq rekmneehnk rlsdtvdkll
      481 sesnerlqlh lkermaaled knsllreves akkqleetqh dkdqlvlnie alraeldhmr
      541 lrgaslhhgr phlgsvpdfr fpmadghtds ystsavlrrp qkgrlaalrd epskvqtlne
      601 qdweraqqas vlanvaqafe sdadvsdged drdtllssvd llspsgqada htlammlqeq
      661 ldainkeirl iqeekenteq raeeiesrvg sgsldnlgrf rsmssippyp asslassspp
      721 gsgrstprri phsparevdr lgvmtlpspd sfliqtsgph qsvvysstsp psstpcysds
      781 sqhaqpsdlr khrrklppsr eevrddktti kcetsppssp ralrldrlhk galhtvshed
      841 irdirnstgs qdgpvsnpss snssqdslhk apkkkgikss igrlfgkkek grpgqtgkea
      901 lgqagvsetd nssqdalgls klggqaeknr klqkkhelle earrqglpfa qwdgptvvvw
      961 lelwvgmpaw yvaacranvk sgaimsalsd teiqreigis nplhrlklrl aiqeimslts
     1021 psapptsrtt tgnvwlthee metlaatpqt edeegswaqt laygdmnhew ignewlpslg
     1081 lpqyrsyfme clvdarmldh ltkkdlrgql kmvdsfhrns fqcgimclrr lnydrkeler
     1141 kreesqseik dvlvwsndrv irwilsiglk eyannliesg vhgallalde tfdfsalall
     1201 lqiptqntqa ravlerefnn llvmgtdrrf dedddksfrr apswrkkfrp kdirglaags
     1261 aetlpanfrv tssmsspsmq pkkmqmdgm
//
LOCUS       XP_054226253            1281 aa            linear   PRI 05-AUG-2025
DEFINITION  liprin-alpha-1 isoform X6 [Homo sapiens].
ACCESSION   XP_054226253
VERSION     XP_054226253.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370278.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 35% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1281
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1281
                     /product="liprin-alpha-1 isoform X6"
                     /calculated_mol_wt=144345
     Region          <45..662
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          <243..>523
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          924..994
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat1"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     1; cd09562"
                     /db_xref="CDD:188961"
     Region          1041..1106
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat2"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     2; cd09565"
                     /db_xref="CDD:188964"
     Region          1126..1197
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat3"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     3; cd09568"
                     /db_xref="CDD:188967"
     CDS             1..1281
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /coded_by="XM_054370278.1:226..4071"
                     /db_xref="GeneID:8500"
                     /db_xref="HGNC:HGNC:9245"
                     /db_xref="MIM:611054"
ORIGIN      
        1 mmcevmptis eaegppgggg ghgsgspsqp dadshfeqlm vsmleerdrl ldtlretqet
       61 laltqgklhe vgherdslqr qlntalpqef aaltkelnvc reqllereee iaelkaernn
      121 trlllehlec lvsrherslr mtvvkrqaqs pagvssevev lkalkslfeh hkaldekvre
      181 rlrvalercs lleeelgath kelmilkeqn nqkktltdgv ldinheqent pstsgkrssd
      241 gslsheedla kvielqeiis kqsreqsqmk erlaslsshv teleedldta rkdlikseem
      301 ntklqrdvre amaqkedmee rittlekryl aaqreatsvh dlndklenei ankdsmhrqt
      361 edknrqlqer lelaeqklqq tlrkaetlpe veaelaqrva alskaeerhg nieerlrqme
      421 aqleeknqel qrarqrekmn eehnkrlsdt vdkllsesne rlqlhlkerm aaledknsll
      481 revesakkql eetqhdkdql vlniealrae ldhmrlrgas lhhgrphlgs vpdfrfpmad
      541 ghtdsystsa vlrrpqkgrl aalrdepskv qtlneqdwer aqqasvlanv aqafesdadv
      601 sdgeddrdtl lssvdllsps gqadahtlam mlqeqldain keirliqeek enteqraeei
      661 esrvgsgsld nlgrfrsmss ippypassla sssppgsgrs tprriphspa revdrlgvmt
      721 lpspdsfliq tsgphqsvvy sstsppsstp cysdssqhaq psdlrkhrrk lppsreevrd
      781 dkttikcets ppsspralrl drlhkgalht vshedirdir nstgsqdgpv snpsssnssq
      841 dslhkapkkk gikssigrlf gkkekgrpgq tgkealgqag vsetdnssqd alglsklggq
      901 aeknrklqkk helleearrq glpfaqwdgp tvvvwlelwv gmpawyvaac ranvksgaim
      961 salsdteiqr eigisnplhr lklrlaiqei msltspsapp tsrtttgnvw ltheemetla
     1021 atpqtedeeg swaqtlaygd mnhewignew lpslglpqyr syfmeclvda rmldhltkkd
     1081 lrgqlkmvds fhrnsfqcgi mclrrlnydr kelerkrees qseikdvlvw sndrvirwil
     1141 siglkeyann liesgvhgal laldetfdfs alalllqipt qntqaravle refnnllvmg
     1201 tdrrfdeddd ksfrrapswr kkfrpkdirg laagsaetlp anfrvtssms spsmqpkkmq
     1261 mdgnvsgtqr ldsatvrtys c
//
LOCUS       XP_054226254            1281 aa            linear   PRI 05-AUG-2025
DEFINITION  liprin-alpha-1 isoform X6 [Homo sapiens].
ACCESSION   XP_054226254
VERSION     XP_054226254.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370279.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 35% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1281
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1281
                     /product="liprin-alpha-1 isoform X6"
                     /calculated_mol_wt=144345
     Region          <45..662
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          <243..>523
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          924..994
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat1"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     1; cd09562"
                     /db_xref="CDD:188961"
     Region          1041..1106
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat2"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     2; cd09565"
                     /db_xref="CDD:188964"
     Region          1126..1197
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat3"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     3; cd09568"
                     /db_xref="CDD:188967"
     CDS             1..1281
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /coded_by="XM_054370279.1:142..3987"
                     /db_xref="GeneID:8500"
                     /db_xref="HGNC:HGNC:9245"
                     /db_xref="MIM:611054"
ORIGIN      
        1 mmcevmptis eaegppgggg ghgsgspsqp dadshfeqlm vsmleerdrl ldtlretqet
       61 laltqgklhe vgherdslqr qlntalpqef aaltkelnvc reqllereee iaelkaernn
      121 trlllehlec lvsrherslr mtvvkrqaqs pagvssevev lkalkslfeh hkaldekvre
      181 rlrvalercs lleeelgath kelmilkeqn nqkktltdgv ldinheqent pstsgkrssd
      241 gslsheedla kvielqeiis kqsreqsqmk erlaslsshv teleedldta rkdlikseem
      301 ntklqrdvre amaqkedmee rittlekryl aaqreatsvh dlndklenei ankdsmhrqt
      361 edknrqlqer lelaeqklqq tlrkaetlpe veaelaqrva alskaeerhg nieerlrqme
      421 aqleeknqel qrarqrekmn eehnkrlsdt vdkllsesne rlqlhlkerm aaledknsll
      481 revesakkql eetqhdkdql vlniealrae ldhmrlrgas lhhgrphlgs vpdfrfpmad
      541 ghtdsystsa vlrrpqkgrl aalrdepskv qtlneqdwer aqqasvlanv aqafesdadv
      601 sdgeddrdtl lssvdllsps gqadahtlam mlqeqldain keirliqeek enteqraeei
      661 esrvgsgsld nlgrfrsmss ippypassla sssppgsgrs tprriphspa revdrlgvmt
      721 lpspdsfliq tsgphqsvvy sstsppsstp cysdssqhaq psdlrkhrrk lppsreevrd
      781 dkttikcets ppsspralrl drlhkgalht vshedirdir nstgsqdgpv snpsssnssq
      841 dslhkapkkk gikssigrlf gkkekgrpgq tgkealgqag vsetdnssqd alglsklggq
      901 aeknrklqkk helleearrq glpfaqwdgp tvvvwlelwv gmpawyvaac ranvksgaim
      961 salsdteiqr eigisnplhr lklrlaiqei msltspsapp tsrtttgnvw ltheemetla
     1021 atpqtedeeg swaqtlaygd mnhewignew lpslglpqyr syfmeclvda rmldhltkkd
     1081 lrgqlkmvds fhrnsfqcgi mclrrlnydr kelerkrees qseikdvlvw sndrvirwil
     1141 siglkeyann liesgvhgal laldetfdfs alalllqipt qntqaravle refnnllvmg
     1201 tdrrfdeddd ksfrrapswr kkfrpkdirg laagsaetlp anfrvtssms spsmqpkkmq
     1261 mdgnvsgtqr ldsatvrtys c
//
LOCUS       XP_054226255            1277 aa            linear   PRI 05-AUG-2025
DEFINITION  liprin-alpha-1 isoform X7 [Homo sapiens].
ACCESSION   XP_054226255
VERSION     XP_054226255.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370280.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 35% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1277
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1277
                     /product="liprin-alpha-1 isoform X7"
                     /calculated_mol_wt=143743
     Region          <45..687
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          <266..>548
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          949..1019
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat1"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     1; cd09562"
                     /db_xref="CDD:188961"
     Region          1037..1102
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat2"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     2; cd09565"
                     /db_xref="CDD:188964"
     Region          1122..1193
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat3"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     3; cd09568"
                     /db_xref="CDD:188967"
     CDS             1..1277
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /coded_by="XM_054370280.1:226..4059"
                     /db_xref="GeneID:8500"
                     /db_xref="HGNC:HGNC:9245"
                     /db_xref="MIM:611054"
ORIGIN      
        1 mmcevmptis eaegppgggg ghgsgspsqp dadshfeqlm vsmleerdrl ldtlretqet
       61 laltqgklhe vgherdslqr qlntalpqef aaltkelnvc reqllereee iaelkaernn
      121 trlllehlec lvsrherslr mtvvkrqaqs pagvssevev lkalkslfeh hkaldekvre
      181 rlrvalercs lleeelgath kelmilkeqn nqkktltdgv ldinheqent pstsgkrssd
      241 gslsheedla kvielqeiis kqsreqsqmk erlaslsshv teleedldta rkdlikseem
      301 ntklqrdvre amaqkedmee rittlekryl aaqreatsvh dlndklenei ankdsmhrqt
      361 edknrqlqer lelaeqklqq tlrkaetlpe veaelaqrva alsksdllss gssaakeakl
      421 leltsklrka eerhgnieer lrqmeaqlee knqelqrarq rekmneehnk rlsdtvdkll
      481 sesnerlqlh lkermaaled knsllreves akkqleetqh dkdqlvlnie alraeldhmr
      541 lrgaslhhgr phlgsvpdfr fpmadghtds ystsavlrrp qkgrlaalrd epskvqtlne
      601 qdweraqqas vlanvaqafe sdadvsdged drdtllssvd llspsgqada htlammlqeq
      661 ldainkeirl iqeekenteq raeeiesrvg sgsldnlgrf rsmssippyp asslassspp
      721 gsgrstprri phsparevdr lgvmtlpspd sfliqtsgph qsvvysstsp psstpcysds
      781 sqhaqpsdlr khrrklppsr eevrddktti kcetsppssp ralrldrlhk galhtvshed
      841 irdirnstgs qdgpvsnpss snssqdslhk apkkkgikss igrlfgkkek grpgqtgkea
      901 lgqagvsetd nssqdalgls klggqaeknr klqkkhelle earrqglpfa qwdgptvvvw
      961 lelwvgmpaw yvaacranvk sgaimsalsd teiqreigis nplhrlklrl aiqeimslts
     1021 psapptsrtq tlaygdmnhe wignewlpsl glpqyrsyfm eclvdarmld hltkkdlrgq
     1081 lkmvdsfhrn sfqcgimclr rlnydrkele rkreesqsei kdvlvwsndr virwilsigl
     1141 keyannlies gvhgallald etfdfsalal llqiptqntq aravlerefn nllvmgtdrr
     1201 fdedddksfr rapswrkkfr pkdirglaag saetlpanfr vtssmsspsm qpkkmqmdgn
     1261 vsgtqrldsa tvrtysc
//
LOCUS       XP_054226256            1276 aa            linear   PRI 05-AUG-2025
DEFINITION  liprin-alpha-1 isoform X8 [Homo sapiens].
ACCESSION   XP_054226256
VERSION     XP_054226256.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370281.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 35% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1276
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1276
                     /product="liprin-alpha-1 isoform X8"
                     /calculated_mol_wt=143615
     Region          <45..687
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          <266..>548
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          949..1019
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat1"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     1; cd09562"
                     /db_xref="CDD:188961"
     Region          1036..1101
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat2"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     2; cd09565"
                     /db_xref="CDD:188964"
     Region          1121..1192
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat3"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     3; cd09568"
                     /db_xref="CDD:188967"
     CDS             1..1276
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /coded_by="XM_054370281.1:226..4056"
                     /db_xref="GeneID:8500"
                     /db_xref="HGNC:HGNC:9245"
                     /db_xref="MIM:611054"
ORIGIN      
        1 mmcevmptis eaegppgggg ghgsgspsqp dadshfeqlm vsmleerdrl ldtlretqet
       61 laltqgklhe vgherdslqr qlntalpqef aaltkelnvc reqllereee iaelkaernn
      121 trlllehlec lvsrherslr mtvvkrqaqs pagvssevev lkalkslfeh hkaldekvre
      181 rlrvalercs lleeelgath kelmilkeqn nqkktltdgv ldinheqent pstsgkrssd
      241 gslsheedla kvielqeiis kqsreqsqmk erlaslsshv teleedldta rkdlikseem
      301 ntklqrdvre amaqkedmee rittlekryl aaqreatsvh dlndklenei ankdsmhrqt
      361 edknrqlqer lelaeqklqq tlrkaetlpe veaelaqrva alsksdllss gssaakeakl
      421 leltsklrka eerhgnieer lrqmeaqlee knqelqrarq rekmneehnk rlsdtvdkll
      481 sesnerlqlh lkermaaled knsllreves akkqleetqh dkdqlvlnie alraeldhmr
      541 lrgaslhhgr phlgsvpdfr fpmadghtds ystsavlrrp qkgrlaalrd epskvqtlne
      601 qdweraqqas vlanvaqafe sdadvsdged drdtllssvd llspsgqada htlammlqeq
      661 ldainkeirl iqeekenteq raeeiesrvg sgsldnlgrf rsmssippyp asslassspp
      721 gsgrstprri phsparevdr lgvmtlpspd sfliqtsgph qsvvysstsp psstpcysds
      781 sqhaqpsdlr khrrklppsr eevrddktti kcetsppssp ralrldrlhk galhtvshed
      841 irdirnstgs qdgpvsnpss snssqdslhk apkkkgikss igrlfgkkek grpgqtgkea
      901 lgqagvsetd nssqdalgls klggqaeknr klqkkhelle earrqglpfa qwdgptvvvw
      961 lelwvgmpaw yvaacranvk sgaimsalsd teiqreigis nplhrlklrl aiqeimslts
     1021 psapptsrtt laygdmnhew ignewlpslg lpqyrsyfme clvdarmldh ltkkdlrgql
     1081 kmvdsfhrns fqcgimclrr lnydrkeler kreesqseik dvlvwsndrv irwilsiglk
     1141 eyannliesg vhgallalde tfdfsalall lqiptqntqa ravlerefnn llvmgtdrrf
     1201 dedddksfrr apswrkkfrp kdirglaags aetlpanfrv tssmsspsmq pkkmqmdgnv
     1261 sgtqrldsat vrtysc
//
LOCUS       XP_054226257            1271 aa            linear   PRI 05-AUG-2025
DEFINITION  liprin-alpha-1 isoform X9 [Homo sapiens].
ACCESSION   XP_054226257
VERSION     XP_054226257.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370282.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 35% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1271
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1271
                     /product="liprin-alpha-1 isoform X9"
                     /calculated_mol_wt=143070
     Region          <45..662
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          <243..>523
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          914..984
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat1"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     1; cd09562"
                     /db_xref="CDD:188961"
     Region          1031..1096
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat2"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     2; cd09565"
                     /db_xref="CDD:188964"
     Region          1116..1187
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat3"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     3; cd09568"
                     /db_xref="CDD:188967"
     CDS             1..1271
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /coded_by="XM_054370282.1:226..4041"
                     /db_xref="GeneID:8500"
                     /db_xref="HGNC:HGNC:9245"
                     /db_xref="MIM:611054"
ORIGIN      
        1 mmcevmptis eaegppgggg ghgsgspsqp dadshfeqlm vsmleerdrl ldtlretqet
       61 laltqgklhe vgherdslqr qlntalpqef aaltkelnvc reqllereee iaelkaernn
      121 trlllehlec lvsrherslr mtvvkrqaqs pagvssevev lkalkslfeh hkaldekvre
      181 rlrvalercs lleeelgath kelmilkeqn nqkktltdgv ldinheqent pstsgkrssd
      241 gslsheedla kvielqeiis kqsreqsqmk erlaslsshv teleedldta rkdlikseem
      301 ntklqrdvre amaqkedmee rittlekryl aaqreatsvh dlndklenei ankdsmhrqt
      361 edknrqlqer lelaeqklqq tlrkaetlpe veaelaqrva alskaeerhg nieerlrqme
      421 aqleeknqel qrarqrekmn eehnkrlsdt vdkllsesne rlqlhlkerm aaledknsll
      481 revesakkql eetqhdkdql vlniealrae ldhmrlrgas lhhgrphlgs vpdfrfpmad
      541 ghtdsystsa vlrrpqkgrl aalrdepskv qtlneqdwer aqqasvlanv aqafesdadv
      601 sdgeddrdtl lssvdllsps gqadahtlam mlqeqldain keirliqeek enteqraeei
      661 esrvgsgsld nlgrfrsmss ippypassla sssppgsgrs tprriphspa revdrlgvmt
      721 lpspdsfliq tsgphqsvvy sstsppsstp cysdssqhaq lppsreevrd dkttikcets
      781 ppsspralrl drlhkgalht vshedirdir nstgsqdgpv snpsssnssq dslhkapkkk
      841 gikssigrlf gkkekgrpgq tgkealgqag vsetdnssqd alglsklggq aeknrklqkk
      901 helleearrq glpfaqwdgp tvvvwlelwv gmpawyvaac ranvksgaim salsdteiqr
      961 eigisnplhr lklrlaiqei msltspsapp tsrtttgnvw ltheemetla atpqtedeeg
     1021 swaqtlaygd mnhewignew lpslglpqyr syfmeclvda rmldhltkkd lrgqlkmvds
     1081 fhrnsfqcgi mclrrlnydr kelerkrees qseikdvlvw sndrvirwil siglkeyann
     1141 liesgvhgal laldetfdfs alalllqipt qntqaravle refnnllvmg tdrrfdeddd
     1201 ksfrrapswr kkfrpkdirg laagsaetlp anfrvtssms spsmqpkkmq mdgnvsgtqr
     1261 ldsatvrtys c
//
LOCUS       XP_054226258            1266 aa            linear   PRI 05-AUG-2025
DEFINITION  liprin-alpha-1 isoform X10 [Homo sapiens].
ACCESSION   XP_054226258
VERSION     XP_054226258.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370283.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 10% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1266
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1266
                     /product="liprin-alpha-1 isoform X10"
                     /calculated_mol_wt=142341
     Region          <45..687
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          <266..>548
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          939..1009
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat1"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     1; cd09562"
                     /db_xref="CDD:188961"
     Region          1026..1091
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat2"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     2; cd09565"
                     /db_xref="CDD:188964"
     Region          1111..1182
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat3"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     3; cd09568"
                     /db_xref="CDD:188967"
     CDS             1..1266
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /coded_by="XM_054370283.1:226..4026"
                     /db_xref="GeneID:8500"
                     /db_xref="HGNC:HGNC:9245"
                     /db_xref="MIM:611054"
ORIGIN      
        1 mmcevmptis eaegppgggg ghgsgspsqp dadshfeqlm vsmleerdrl ldtlretqet
       61 laltqgklhe vgherdslqr qlntalpqef aaltkelnvc reqllereee iaelkaernn
      121 trlllehlec lvsrherslr mtvvkrqaqs pagvssevev lkalkslfeh hkaldekvre
      181 rlrvalercs lleeelgath kelmilkeqn nqkktltdgv ldinheqent pstsgkrssd
      241 gslsheedla kvielqeiis kqsreqsqmk erlaslsshv teleedldta rkdlikseem
      301 ntklqrdvre amaqkedmee rittlekryl aaqreatsvh dlndklenei ankdsmhrqt
      361 edknrqlqer lelaeqklqq tlrkaetlpe veaelaqrva alsksdllss gssaakeakl
      421 leltsklrka eerhgnieer lrqmeaqlee knqelqrarq rekmneehnk rlsdtvdkll
      481 sesnerlqlh lkermaaled knsllreves akkqleetqh dkdqlvlnie alraeldhmr
      541 lrgaslhhgr phlgsvpdfr fpmadghtds ystsavlrrp qkgrlaalrd epskvqtlne
      601 qdweraqqas vlanvaqafe sdadvsdged drdtllssvd llspsgqada htlammlqeq
      661 ldainkeirl iqeekenteq raeeiesrvg sgsldnlgrf rsmssippyp asslassspp
      721 gsgrstprri phsparevdr lgvmtlpspd sfliqtsgph qsvvysstsp psstpcysds
      781 sqhaqlppsr eevrddktti kcetsppssp ralrldrlhk galhtvshed irdirnstgs
      841 qdgpvsnpss snssqdslhk apkkkgikss igrlfgkkek grpgqtgkea lgqagvsetd
      901 nssqdalgls klggqaeknr klqkkhelle earrqglpfa qwdgptvvvw lelwvgmpaw
      961 yvaacranvk sgaimsalsd teiqreigis nplhrlklrl aiqeimslts psapptsrtt
     1021 laygdmnhew ignewlpslg lpqyrsyfme clvdarmldh ltkkdlrgql kmvdsfhrns
     1081 fqcgimclrr lnydrkeler kreesqseik dvlvwsndrv irwilsiglk eyannliesg
     1141 vhgallalde tfdfsalall lqiptqntqa ravlerefnn llvmgtdrrf dedddksfrr
     1201 apswrkkfrp kdirglaags aetlpanfrv tssmsspsmq pkkmqmdgnv sgtqrldsat
     1261 vrtysc
//
LOCUS       XP_054226259            1257 aa            linear   PRI 05-AUG-2025
DEFINITION  liprin-alpha-1 isoform X11 [Homo sapiens].
ACCESSION   XP_054226259
VERSION     XP_054226259.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370284.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 35% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1257
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1257
                     /product="liprin-alpha-1 isoform X11"
                     /calculated_mol_wt=141608
     Region          <45..687
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          <266..>548
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          900..970
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat1"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     1; cd09562"
                     /db_xref="CDD:188961"
     Region          1017..1082
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat2"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     2; cd09565"
                     /db_xref="CDD:188964"
     Region          1102..1173
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat3"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     3; cd09568"
                     /db_xref="CDD:188967"
     CDS             1..1257
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /coded_by="XM_054370284.1:226..3999"
                     /db_xref="GeneID:8500"
                     /db_xref="HGNC:HGNC:9245"
                     /db_xref="MIM:611054"
ORIGIN      
        1 mmcevmptis eaegppgggg ghgsgspsqp dadshfeqlm vsmleerdrl ldtlretqet
       61 laltqgklhe vgherdslqr qlntalpqef aaltkelnvc reqllereee iaelkaernn
      121 trlllehlec lvsrherslr mtvvkrqaqs pagvssevev lkalkslfeh hkaldekvre
      181 rlrvalercs lleeelgath kelmilkeqn nqkktltdgv ldinheqent pstsgkrssd
      241 gslsheedla kvielqeiis kqsreqsqmk erlaslsshv teleedldta rkdlikseem
      301 ntklqrdvre amaqkedmee rittlekryl aaqreatsvh dlndklenei ankdsmhrqt
      361 edknrqlqer lelaeqklqq tlrkaetlpe veaelaqrva alsksdllss gssaakeakl
      421 leltsklrka eerhgnieer lrqmeaqlee knqelqrarq rekmneehnk rlsdtvdkll
      481 sesnerlqlh lkermaaled knsllreves akkqleetqh dkdqlvlnie alraeldhmr
      541 lrgaslhhgr phlgsvpdfr fpmadghtds ystsavlrrp qkgrlaalrd epskvqtlne
      601 qdweraqqas vlanvaqafe sdadvsdged drdtllssvd llspsgqada htlammlqeq
      661 ldainkeirl iqeekenteq raeeiesrvg sgsldnlgrf rsmssippyp asslassspp
      721 gsgrstprri phsparevdr lgvmtllpps reevrddktt ikcetsppss pralrldrlh
      781 kgalhtvshe dirdirnstg sqdgpvsnps ssnssqdslh kapkkkgiks sigrlfgkke
      841 kgrpgqtgke algqagvset dnssqdalgl sklggqaekn rklqkkhell eearrqglpf
      901 aqwdgptvvv wlelwvgmpa wyvaacranv ksgaimsals dteiqreigi snplhrlklr
      961 laiqeimslt spsapptsrt ttgnvwlthe emetlaatpq tedeegswaq tlaygdmnhe
     1021 wignewlpsl glpqyrsyfm eclvdarmld hltkkdlrgq lkmvdsfhrn sfqcgimclr
     1081 rlnydrkele rkreesqsei kdvlvwsndr virwilsigl keyannlies gvhgallald
     1141 etfdfsalal llqiptqntq aravlerefn nllvmgtdrr fdedddksfr rapswrkkfr
     1201 pkdirglaag saetlpanfr vtssmsspsm qpkkmqmdgn vsgtqrldsa tvrtysc
//
LOCUS       XP_054226260            1251 aa            linear   PRI 05-AUG-2025
DEFINITION  liprin-alpha-1 isoform X12 [Homo sapiens].
ACCESSION   XP_054226260
VERSION     XP_054226260.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370285.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 35% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1251
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1251
                     /product="liprin-alpha-1 isoform X12"
                     /calculated_mol_wt=141000
     Region          <45..662
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          <243..>523
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          924..994
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat1"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     1; cd09562"
                     /db_xref="CDD:188961"
     Region          1011..1076
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat2"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     2; cd09565"
                     /db_xref="CDD:188964"
     Region          1096..1167
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat3"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     3; cd09568"
                     /db_xref="CDD:188967"
     CDS             1..1251
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /coded_by="XM_054370285.1:226..3981"
                     /db_xref="GeneID:8500"
                     /db_xref="HGNC:HGNC:9245"
                     /db_xref="MIM:611054"
ORIGIN      
        1 mmcevmptis eaegppgggg ghgsgspsqp dadshfeqlm vsmleerdrl ldtlretqet
       61 laltqgklhe vgherdslqr qlntalpqef aaltkelnvc reqllereee iaelkaernn
      121 trlllehlec lvsrherslr mtvvkrqaqs pagvssevev lkalkslfeh hkaldekvre
      181 rlrvalercs lleeelgath kelmilkeqn nqkktltdgv ldinheqent pstsgkrssd
      241 gslsheedla kvielqeiis kqsreqsqmk erlaslsshv teleedldta rkdlikseem
      301 ntklqrdvre amaqkedmee rittlekryl aaqreatsvh dlndklenei ankdsmhrqt
      361 edknrqlqer lelaeqklqq tlrkaetlpe veaelaqrva alskaeerhg nieerlrqme
      421 aqleeknqel qrarqrekmn eehnkrlsdt vdkllsesne rlqlhlkerm aaledknsll
      481 revesakkql eetqhdkdql vlniealrae ldhmrlrgas lhhgrphlgs vpdfrfpmad
      541 ghtdsystsa vlrrpqkgrl aalrdepskv qtlneqdwer aqqasvlanv aqafesdadv
      601 sdgeddrdtl lssvdllsps gqadahtlam mlqeqldain keirliqeek enteqraeei
      661 esrvgsgsld nlgrfrsmss ippypassla sssppgsgrs tprriphspa revdrlgvmt
      721 lpspdsfliq tsgphqsvvy sstsppsstp cysdssqhaq psdlrkhrrk lppsreevrd
      781 dkttikcets ppsspralrl drlhkgalht vshedirdir nstgsqdgpv snpsssnssq
      841 dslhkapkkk gikssigrlf gkkekgrpgq tgkealgqag vsetdnssqd alglsklggq
      901 aeknrklqkk helleearrq glpfaqwdgp tvvvwlelwv gmpawyvaac ranvksgaim
      961 salsdteiqr eigisnplhr lklrlaiqei msltspsapp tsrttlaygd mnhewignew
     1021 lpslglpqyr syfmeclvda rmldhltkkd lrgqlkmvds fhrnsfqcgi mclrrlnydr
     1081 kelerkrees qseikdvlvw sndrvirwil siglkeyann liesgvhgal laldetfdfs
     1141 alalllqipt qntqaravle refnnllvmg tdrrfdeddd ksfrrapswr kkfrpkdirg
     1201 laagsaetlp anfrvtssms spsmqpkkmq mdgnvsgtqr ldsatvrtys c
//
LOCUS       XP_054226261            1242 aa            linear   PRI 05-AUG-2025
DEFINITION  liprin-alpha-1 isoform X13 [Homo sapiens].
ACCESSION   XP_054226261
VERSION     XP_054226261.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370286.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 36% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1242
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1242
                     /product="liprin-alpha-1 isoform X13"
                     /calculated_mol_wt=140267
     Region          <45..662
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          <243..>523
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          885..955
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat1"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     1; cd09562"
                     /db_xref="CDD:188961"
     Region          1002..1067
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat2"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     2; cd09565"
                     /db_xref="CDD:188964"
     Region          1087..1158
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat3"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     3; cd09568"
                     /db_xref="CDD:188967"
     CDS             1..1242
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /coded_by="XM_054370286.1:226..3954"
                     /db_xref="GeneID:8500"
                     /db_xref="HGNC:HGNC:9245"
                     /db_xref="MIM:611054"
ORIGIN      
        1 mmcevmptis eaegppgggg ghgsgspsqp dadshfeqlm vsmleerdrl ldtlretqet
       61 laltqgklhe vgherdslqr qlntalpqef aaltkelnvc reqllereee iaelkaernn
      121 trlllehlec lvsrherslr mtvvkrqaqs pagvssevev lkalkslfeh hkaldekvre
      181 rlrvalercs lleeelgath kelmilkeqn nqkktltdgv ldinheqent pstsgkrssd
      241 gslsheedla kvielqeiis kqsreqsqmk erlaslsshv teleedldta rkdlikseem
      301 ntklqrdvre amaqkedmee rittlekryl aaqreatsvh dlndklenei ankdsmhrqt
      361 edknrqlqer lelaeqklqq tlrkaetlpe veaelaqrva alskaeerhg nieerlrqme
      421 aqleeknqel qrarqrekmn eehnkrlsdt vdkllsesne rlqlhlkerm aaledknsll
      481 revesakkql eetqhdkdql vlniealrae ldhmrlrgas lhhgrphlgs vpdfrfpmad
      541 ghtdsystsa vlrrpqkgrl aalrdepskv qtlneqdwer aqqasvlanv aqafesdadv
      601 sdgeddrdtl lssvdllsps gqadahtlam mlqeqldain keirliqeek enteqraeei
      661 esrvgsgsld nlgrfrsmss ippypassla sssppgsgrs tprriphspa revdrlgvmt
      721 lpsdlrkhrr klppsreevr ddkttikcet sppsspralr ldrlhkgalh tvshedirdi
      781 rnstgsqdgp vsnpsssnss qdslhkapkk kgikssigrl fgkkekgrpg qtgkealgqa
      841 gvsetdnssq dalglsklgg qaeknrklqk khelleearr qglpfaqwdg ptvvvwlelw
      901 vgmpawyvaa cranvksgai msalsdteiq reigisnplh rlklrlaiqe imsltspsap
      961 ptsrtttgnv wltheemetl aatpqtedee gswaqtlayg dmnhewigne wlpslglpqy
     1021 rsyfmeclvd armldhltkk dlrgqlkmvd sfhrnsfqcg imclrrlnyd rkelerkree
     1081 sqseikdvlv wsndrvirwi lsiglkeyan nliesgvhga llaldetfdf salalllqip
     1141 tqntqaravl erefnnllvm gtdrrfdedd dksfrrapsw rkkfrpkdir glaagsaetl
     1201 panfrvtssm sspsmqpkkm qmdgnvsgtq rldsatvrty sc
//
LOCUS       XP_054226262            1242 aa            linear   PRI 05-AUG-2025
DEFINITION  liprin-alpha-1 isoform X14 [Homo sapiens].
ACCESSION   XP_054226262
VERSION     XP_054226262.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370287.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 36% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1242
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1242
                     /product="liprin-alpha-1 isoform X14"
                     /calculated_mol_wt=139854
     Region          <45..662
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          <243..>523
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          914..984
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat1"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     1; cd09562"
                     /db_xref="CDD:188961"
     Region          1002..1067
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat2"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     2; cd09565"
                     /db_xref="CDD:188964"
     Region          1087..1158
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat3"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     3; cd09568"
                     /db_xref="CDD:188967"
     CDS             1..1242
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /coded_by="XM_054370287.1:226..3954"
                     /db_xref="GeneID:8500"
                     /db_xref="HGNC:HGNC:9245"
                     /db_xref="MIM:611054"
ORIGIN      
        1 mmcevmptis eaegppgggg ghgsgspsqp dadshfeqlm vsmleerdrl ldtlretqet
       61 laltqgklhe vgherdslqr qlntalpqef aaltkelnvc reqllereee iaelkaernn
      121 trlllehlec lvsrherslr mtvvkrqaqs pagvssevev lkalkslfeh hkaldekvre
      181 rlrvalercs lleeelgath kelmilkeqn nqkktltdgv ldinheqent pstsgkrssd
      241 gslsheedla kvielqeiis kqsreqsqmk erlaslsshv teleedldta rkdlikseem
      301 ntklqrdvre amaqkedmee rittlekryl aaqreatsvh dlndklenei ankdsmhrqt
      361 edknrqlqer lelaeqklqq tlrkaetlpe veaelaqrva alskaeerhg nieerlrqme
      421 aqleeknqel qrarqrekmn eehnkrlsdt vdkllsesne rlqlhlkerm aaledknsll
      481 revesakkql eetqhdkdql vlniealrae ldhmrlrgas lhhgrphlgs vpdfrfpmad
      541 ghtdsystsa vlrrpqkgrl aalrdepskv qtlneqdwer aqqasvlanv aqafesdadv
      601 sdgeddrdtl lssvdllsps gqadahtlam mlqeqldain keirliqeek enteqraeei
      661 esrvgsgsld nlgrfrsmss ippypassla sssppgsgrs tprriphspa revdrlgvmt
      721 lpspdsfliq tsgphqsvvy sstsppsstp cysdssqhaq lppsreevrd dkttikcets
      781 ppsspralrl drlhkgalht vshedirdir nstgsqdgpv snpsssnssq dslhkapkkk
      841 gikssigrlf gkkekgrpgq tgkealgqag vsetdnssqd alglsklggq aeknrklqkk
      901 helleearrq glpfaqwdgp tvvvwlelwv gmpawyvaac ranvksgaim salsdteiqr
      961 eigisnplhr lklrlaiqei msltspsapp tsrtqtlayg dmnhewigne wlpslglpqy
     1021 rsyfmeclvd armldhltkk dlrgqlkmvd sfhrnsfqcg imclrrlnyd rkelerkree
     1081 sqseikdvlv wsndrvirwi lsiglkeyan nliesgvhga llaldetfdf salalllqip
     1141 tqntqaravl erefnnllvm gtdrrfdedd dksfrrapsw rkkfrpkdir glaagsaetl
     1201 panfrvtssm sspsmqpkkm qmdgnvsgtq rldsatvrty sc
//
LOCUS       XP_054226263            1241 aa            linear   PRI 05-AUG-2025
DEFINITION  liprin-alpha-1 isoform X15 [Homo sapiens].
ACCESSION   XP_054226263
VERSION     XP_054226263.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370288.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 36% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1241
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1241
                     /product="liprin-alpha-1 isoform X15"
                     /calculated_mol_wt=139726
     Region          <45..662
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          <243..>523
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          914..984
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat1"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     1; cd09562"
                     /db_xref="CDD:188961"
     Region          1001..1066
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat2"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     2; cd09565"
                     /db_xref="CDD:188964"
     Region          1086..1157
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat3"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     3; cd09568"
                     /db_xref="CDD:188967"
     CDS             1..1241
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /coded_by="XM_054370288.1:226..3951"
                     /db_xref="GeneID:8500"
                     /db_xref="HGNC:HGNC:9245"
                     /db_xref="MIM:611054"
ORIGIN      
        1 mmcevmptis eaegppgggg ghgsgspsqp dadshfeqlm vsmleerdrl ldtlretqet
       61 laltqgklhe vgherdslqr qlntalpqef aaltkelnvc reqllereee iaelkaernn
      121 trlllehlec lvsrherslr mtvvkrqaqs pagvssevev lkalkslfeh hkaldekvre
      181 rlrvalercs lleeelgath kelmilkeqn nqkktltdgv ldinheqent pstsgkrssd
      241 gslsheedla kvielqeiis kqsreqsqmk erlaslsshv teleedldta rkdlikseem
      301 ntklqrdvre amaqkedmee rittlekryl aaqreatsvh dlndklenei ankdsmhrqt
      361 edknrqlqer lelaeqklqq tlrkaetlpe veaelaqrva alskaeerhg nieerlrqme
      421 aqleeknqel qrarqrekmn eehnkrlsdt vdkllsesne rlqlhlkerm aaledknsll
      481 revesakkql eetqhdkdql vlniealrae ldhmrlrgas lhhgrphlgs vpdfrfpmad
      541 ghtdsystsa vlrrpqkgrl aalrdepskv qtlneqdwer aqqasvlanv aqafesdadv
      601 sdgeddrdtl lssvdllsps gqadahtlam mlqeqldain keirliqeek enteqraeei
      661 esrvgsgsld nlgrfrsmss ippypassla sssppgsgrs tprriphspa revdrlgvmt
      721 lpspdsfliq tsgphqsvvy sstsppsstp cysdssqhaq lppsreevrd dkttikcets
      781 ppsspralrl drlhkgalht vshedirdir nstgsqdgpv snpsssnssq dslhkapkkk
      841 gikssigrlf gkkekgrpgq tgkealgqag vsetdnssqd alglsklggq aeknrklqkk
      901 helleearrq glpfaqwdgp tvvvwlelwv gmpawyvaac ranvksgaim salsdteiqr
      961 eigisnplhr lklrlaiqei msltspsapp tsrttlaygd mnhewignew lpslglpqyr
     1021 syfmeclvda rmldhltkkd lrgqlkmvds fhrnsfqcgi mclrrlnydr kelerkrees
     1081 qseikdvlvw sndrvirwil siglkeyann liesgvhgal laldetfdfs alalllqipt
     1141 qntqaravle refnnllvmg tdrrfdeddd ksfrrapswr kkfrpkdirg laagsaetlp
     1201 anfrvtssms spsmqpkkmq mdgnvsgtqr ldsatvrtys c
//
LOCUS       XP_054226264            1237 aa            linear   PRI 05-AUG-2025
DEFINITION  liprin-alpha-1 isoform X16 [Homo sapiens].
ACCESSION   XP_054226264
VERSION     XP_054226264.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370289.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 36% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1237
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1237
                     /product="liprin-alpha-1 isoform X16"
                     /calculated_mol_wt=139538
     Region          <45..687
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          <266..>548
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          910..980
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat1"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     1; cd09562"
                     /db_xref="CDD:188961"
     Region          997..1062
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat2"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     2; cd09565"
                     /db_xref="CDD:188964"
     Region          1082..1153
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat3"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     3; cd09568"
                     /db_xref="CDD:188967"
     CDS             1..1237
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /coded_by="XM_054370289.1:226..3939"
                     /db_xref="GeneID:8500"
                     /db_xref="HGNC:HGNC:9245"
                     /db_xref="MIM:611054"
ORIGIN      
        1 mmcevmptis eaegppgggg ghgsgspsqp dadshfeqlm vsmleerdrl ldtlretqet
       61 laltqgklhe vgherdslqr qlntalpqef aaltkelnvc reqllereee iaelkaernn
      121 trlllehlec lvsrherslr mtvvkrqaqs pagvssevev lkalkslfeh hkaldekvre
      181 rlrvalercs lleeelgath kelmilkeqn nqkktltdgv ldinheqent pstsgkrssd
      241 gslsheedla kvielqeiis kqsreqsqmk erlaslsshv teleedldta rkdlikseem
      301 ntklqrdvre amaqkedmee rittlekryl aaqreatsvh dlndklenei ankdsmhrqt
      361 edknrqlqer lelaeqklqq tlrkaetlpe veaelaqrva alsksdllss gssaakeakl
      421 leltsklrka eerhgnieer lrqmeaqlee knqelqrarq rekmneehnk rlsdtvdkll
      481 sesnerlqlh lkermaaled knsllreves akkqleetqh dkdqlvlnie alraeldhmr
      541 lrgaslhhgr phlgsvpdfr fpmadghtds ystsavlrrp qkgrlaalrd epskvqtlne
      601 qdweraqqas vlanvaqafe sdadvsdged drdtllssvd llspsgqada htlammlqeq
      661 ldainkeirl iqeekenteq raeeiesrvg sgsldnlgrf rsmssippyp asslassspp
      721 gsgrstprri phsparevdr lgvmtlpsdl rkhrrklpps reevrddktt ikcetsppss
      781 pralrldrlh kgalhtvshe dirdirnstg sqdgpvsnps ssnssqdslh kapkkkgiks
      841 sigrlfgkke kgrpgqtgke algqagvset dnssqdalgl sklggqaekn rklqkkhell
      901 eearrqglpf aqwdgptvvv wlelwvgmpa wyvaacranv ksgaimsals dteiqreigi
      961 snplhrlklr laiqeimslt spsapptsrt tlaygdmnhe wignewlpsl glpqyrsyfm
     1021 eclvdarmld hltkkdlrgq lkmvdsfhrn sfqcgimclr rlnydrkele rkreesqsei
     1081 kdvlvwsndr virwilsigl keyannlies gvhgallald etfdfsalal llqiptqntq
     1141 aravlerefn nllvmgtdrr fdedddksfr rapswrkkfr pkdirglaag saetlpanfr
     1201 vtssmsspsm qpkkmqmdgn vsgtqrldsa tvrtysc
//
LOCUS       XP_054226265            1232 aa            linear   PRI 05-AUG-2025
DEFINITION  liprin-alpha-1 isoform X17 [Homo sapiens].
ACCESSION   XP_054226265
VERSION     XP_054226265.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370290.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 36% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1232
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1232
                     /product="liprin-alpha-1 isoform X17"
                     /calculated_mol_wt=138993
     Region          <45..662
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          <243..>523
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          875..945
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat1"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     1; cd09562"
                     /db_xref="CDD:188961"
     Region          992..1057
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat2"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     2; cd09565"
                     /db_xref="CDD:188964"
     Region          1077..1148
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat3"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     3; cd09568"
                     /db_xref="CDD:188967"
     CDS             1..1232
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /coded_by="XM_054370290.1:226..3924"
                     /db_xref="GeneID:8500"
                     /db_xref="HGNC:HGNC:9245"
                     /db_xref="MIM:611054"
ORIGIN      
        1 mmcevmptis eaegppgggg ghgsgspsqp dadshfeqlm vsmleerdrl ldtlretqet
       61 laltqgklhe vgherdslqr qlntalpqef aaltkelnvc reqllereee iaelkaernn
      121 trlllehlec lvsrherslr mtvvkrqaqs pagvssevev lkalkslfeh hkaldekvre
      181 rlrvalercs lleeelgath kelmilkeqn nqkktltdgv ldinheqent pstsgkrssd
      241 gslsheedla kvielqeiis kqsreqsqmk erlaslsshv teleedldta rkdlikseem
      301 ntklqrdvre amaqkedmee rittlekryl aaqreatsvh dlndklenei ankdsmhrqt
      361 edknrqlqer lelaeqklqq tlrkaetlpe veaelaqrva alskaeerhg nieerlrqme
      421 aqleeknqel qrarqrekmn eehnkrlsdt vdkllsesne rlqlhlkerm aaledknsll
      481 revesakkql eetqhdkdql vlniealrae ldhmrlrgas lhhgrphlgs vpdfrfpmad
      541 ghtdsystsa vlrrpqkgrl aalrdepskv qtlneqdwer aqqasvlanv aqafesdadv
      601 sdgeddrdtl lssvdllsps gqadahtlam mlqeqldain keirliqeek enteqraeei
      661 esrvgsgsld nlgrfrsmss ippypassla sssppgsgrs tprriphspa revdrlgvmt
      721 llppsreevr ddkttikcet sppsspralr ldrlhkgalh tvshedirdi rnstgsqdgp
      781 vsnpsssnss qdslhkapkk kgikssigrl fgkkekgrpg qtgkealgqa gvsetdnssq
      841 dalglsklgg qaeknrklqk khelleearr qglpfaqwdg ptvvvwlelw vgmpawyvaa
      901 cranvksgai msalsdteiq reigisnplh rlklrlaiqe imsltspsap ptsrtttgnv
      961 wltheemetl aatpqtedee gswaqtlayg dmnhewigne wlpslglpqy rsyfmeclvd
     1021 armldhltkk dlrgqlkmvd sfhrnsfqcg imclrrlnyd rkelerkree sqseikdvlv
     1081 wsndrvirwi lsiglkeyan nliesgvhga llaldetfdf salalllqip tqntqaravl
     1141 erefnnllvm gtdrrfdedd dksfrrapsw rkkfrpkdir glaagsaetl panfrvtssm
     1201 sspsmqpkkm qmdgnvsgtq rldsatvrty sc
//
LOCUS       XP_054226266            1228 aa            linear   PRI 05-AUG-2025
DEFINITION  liprin-alpha-1 isoform X18 [Homo sapiens].
ACCESSION   XP_054226266
VERSION     XP_054226266.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370291.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 36% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1228
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1228
                     /product="liprin-alpha-1 isoform X18"
                     /calculated_mol_wt=138391
     Region          <45..687
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          <266..>548
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          900..970
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat1"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     1; cd09562"
                     /db_xref="CDD:188961"
     Region          988..1053
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat2"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     2; cd09565"
                     /db_xref="CDD:188964"
     Region          1073..1144
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat3"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     3; cd09568"
                     /db_xref="CDD:188967"
     CDS             1..1228
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /coded_by="XM_054370291.1:226..3912"
                     /db_xref="GeneID:8500"
                     /db_xref="HGNC:HGNC:9245"
                     /db_xref="MIM:611054"
ORIGIN      
        1 mmcevmptis eaegppgggg ghgsgspsqp dadshfeqlm vsmleerdrl ldtlretqet
       61 laltqgklhe vgherdslqr qlntalpqef aaltkelnvc reqllereee iaelkaernn
      121 trlllehlec lvsrherslr mtvvkrqaqs pagvssevev lkalkslfeh hkaldekvre
      181 rlrvalercs lleeelgath kelmilkeqn nqkktltdgv ldinheqent pstsgkrssd
      241 gslsheedla kvielqeiis kqsreqsqmk erlaslsshv teleedldta rkdlikseem
      301 ntklqrdvre amaqkedmee rittlekryl aaqreatsvh dlndklenei ankdsmhrqt
      361 edknrqlqer lelaeqklqq tlrkaetlpe veaelaqrva alsksdllss gssaakeakl
      421 leltsklrka eerhgnieer lrqmeaqlee knqelqrarq rekmneehnk rlsdtvdkll
      481 sesnerlqlh lkermaaled knsllreves akkqleetqh dkdqlvlnie alraeldhmr
      541 lrgaslhhgr phlgsvpdfr fpmadghtds ystsavlrrp qkgrlaalrd epskvqtlne
      601 qdweraqqas vlanvaqafe sdadvsdged drdtllssvd llspsgqada htlammlqeq
      661 ldainkeirl iqeekenteq raeeiesrvg sgsldnlgrf rsmssippyp asslassspp
      721 gsgrstprri phsparevdr lgvmtllpps reevrddktt ikcetsppss pralrldrlh
      781 kgalhtvshe dirdirnstg sqdgpvsnps ssnssqdslh kapkkkgiks sigrlfgkke
      841 kgrpgqtgke algqagvset dnssqdalgl sklggqaekn rklqkkhell eearrqglpf
      901 aqwdgptvvv wlelwvgmpa wyvaacranv ksgaimsals dteiqreigi snplhrlklr
      961 laiqeimslt spsapptsrt qtlaygdmnh ewignewlps lglpqyrsyf meclvdarml
     1021 dhltkkdlrg qlkmvdsfhr nsfqcgimcl rrlnydrkel erkreesqse ikdvlvwsnd
     1081 rvirwilsig lkeyannlie sgvhgallal detfdfsala lllqiptqnt qaravleref
     1141 nnllvmgtdr rfdedddksf rrapswrkkf rpkdirglaa gsaetlpanf rvtssmssps
     1201 mqpkkmqmdg nvsgtqrlds atvrtysc
//
LOCUS       XP_054226267            1227 aa            linear   PRI 05-AUG-2025
DEFINITION  liprin-alpha-1 isoform X19 [Homo sapiens].
ACCESSION   XP_054226267
VERSION     XP_054226267.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370292.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 36% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1227
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1227
                     /product="liprin-alpha-1 isoform X19"
                     /calculated_mol_wt=138263
     Region          <45..687
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          <266..>548
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          900..970
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat1"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     1; cd09562"
                     /db_xref="CDD:188961"
     Region          987..1052
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat2"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     2; cd09565"
                     /db_xref="CDD:188964"
     Region          1072..1143
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat3"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     3; cd09568"
                     /db_xref="CDD:188967"
     CDS             1..1227
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /coded_by="XM_054370292.1:226..3909"
                     /db_xref="GeneID:8500"
                     /db_xref="HGNC:HGNC:9245"
                     /db_xref="MIM:611054"
ORIGIN      
        1 mmcevmptis eaegppgggg ghgsgspsqp dadshfeqlm vsmleerdrl ldtlretqet
       61 laltqgklhe vgherdslqr qlntalpqef aaltkelnvc reqllereee iaelkaernn
      121 trlllehlec lvsrherslr mtvvkrqaqs pagvssevev lkalkslfeh hkaldekvre
      181 rlrvalercs lleeelgath kelmilkeqn nqkktltdgv ldinheqent pstsgkrssd
      241 gslsheedla kvielqeiis kqsreqsqmk erlaslsshv teleedldta rkdlikseem
      301 ntklqrdvre amaqkedmee rittlekryl aaqreatsvh dlndklenei ankdsmhrqt
      361 edknrqlqer lelaeqklqq tlrkaetlpe veaelaqrva alsksdllss gssaakeakl
      421 leltsklrka eerhgnieer lrqmeaqlee knqelqrarq rekmneehnk rlsdtvdkll
      481 sesnerlqlh lkermaaled knsllreves akkqleetqh dkdqlvlnie alraeldhmr
      541 lrgaslhhgr phlgsvpdfr fpmadghtds ystsavlrrp qkgrlaalrd epskvqtlne
      601 qdweraqqas vlanvaqafe sdadvsdged drdtllssvd llspsgqada htlammlqeq
      661 ldainkeirl iqeekenteq raeeiesrvg sgsldnlgrf rsmssippyp asslassspp
      721 gsgrstprri phsparevdr lgvmtllpps reevrddktt ikcetsppss pralrldrlh
      781 kgalhtvshe dirdirnstg sqdgpvsnps ssnssqdslh kapkkkgiks sigrlfgkke
      841 kgrpgqtgke algqagvset dnssqdalgl sklggqaekn rklqkkhell eearrqglpf
      901 aqwdgptvvv wlelwvgmpa wyvaacranv ksgaimsals dteiqreigi snplhrlklr
      961 laiqeimslt spsapptsrt tlaygdmnhe wignewlpsl glpqyrsyfm eclvdarmld
     1021 hltkkdlrgq lkmvdsfhrn sfqcgimclr rlnydrkele rkreesqsei kdvlvwsndr
     1081 virwilsigl keyannlies gvhgallald etfdfsalal llqiptqntq aravlerefn
     1141 nllvmgtdrr fdedddksfr rapswrkkfr pkdirglaag saetlpanfr vtssmsspsm
     1201 qpkkmqmdgn vsgtqrldsa tvrtysc
//
LOCUS       XP_054226268            1223 aa            linear   PRI 05-AUG-2025
DEFINITION  liprin-alpha-1 isoform X20 [Homo sapiens].
ACCESSION   XP_054226268
VERSION     XP_054226268.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370293.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 36% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1223
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1223
                     /product="liprin-alpha-1 isoform X20"
                     /calculated_mol_wt=137961
     Region          <45..662
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          <243..>523
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          875..945
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat1"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     1; cd09562"
                     /db_xref="CDD:188961"
     Region          983..1048
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat2"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     2; cd09565"
                     /db_xref="CDD:188964"
     Region          1068..1139
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat3"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     3; cd09568"
                     /db_xref="CDD:188967"
     CDS             1..1223
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /coded_by="XM_054370293.1:226..3897"
                     /db_xref="GeneID:8500"
                     /db_xref="HGNC:HGNC:9245"
                     /db_xref="MIM:611054"
ORIGIN      
        1 mmcevmptis eaegppgggg ghgsgspsqp dadshfeqlm vsmleerdrl ldtlretqet
       61 laltqgklhe vgherdslqr qlntalpqef aaltkelnvc reqllereee iaelkaernn
      121 trlllehlec lvsrherslr mtvvkrqaqs pagvssevev lkalkslfeh hkaldekvre
      181 rlrvalercs lleeelgath kelmilkeqn nqkktltdgv ldinheqent pstsgkrssd
      241 gslsheedla kvielqeiis kqsreqsqmk erlaslsshv teleedldta rkdlikseem
      301 ntklqrdvre amaqkedmee rittlekryl aaqreatsvh dlndklenei ankdsmhrqt
      361 edknrqlqer lelaeqklqq tlrkaetlpe veaelaqrva alskaeerhg nieerlrqme
      421 aqleeknqel qrarqrekmn eehnkrlsdt vdkllsesne rlqlhlkerm aaledknsll
      481 revesakkql eetqhdkdql vlniealrae ldhmrlrgas lhhgrphlgs vpdfrfpmad
      541 ghtdsystsa vlrrpqkgrl aalrdepskv qtlneqdwer aqqasvlanv aqafesdadv
      601 sdgeddrdtl lssvdllsps gqadahtlam mlqeqldain keirliqeek enteqraeei
      661 esrvgsgsld nlgrfrsmss ippypassla sssppgsgrs tprriphspa revdrlgvmt
      721 llppsreevr ddkttikcet sppsspralr ldrlhkgalh tvshedirdi rnstgsqdgp
      781 vsnpsssnss qdslhkapkk kgikssigrl fgkkekgrpg qtgkealgqa gvsetdnssq
      841 dalglsklgg qaeknrklqk khelleearr qglpfaqwdg ptvvvwlelw vgmpawyvaa
      901 cranvksgai msalsdteiq reigisnplh rlklrlaiqe imsltspsap ptsrtttgnv
      961 wltheemetl aatpqttlay gdmnhewign ewlpslglpq yrsyfmeclv darmldhltk
     1021 kdlrgqlkmv dsfhrnsfqc gimclrrlny drkelerkre esqseikdvl vwsndrvirw
     1081 ilsiglkeya nnliesgvhg allaldetfd fsalalllqi ptqntqarav lerefnnllv
     1141 mgtdrrfded ddksfrraps wrkkfrpkdi rglaagsaet lpanfrvtss msspsmqpkk
     1201 mqmdgnvsgt qrldsatvrt ysc
//
LOCUS       XP_054226269            1217 aa            linear   PRI 05-AUG-2025
DEFINITION  liprin-alpha-1 isoform X21 [Homo sapiens].
ACCESSION   XP_054226269
VERSION     XP_054226269.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370294.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1217
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1217
                     /product="liprin-alpha-1 isoform X21"
                     /calculated_mol_wt=137520
     Region          <45..687
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          <266..>548
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          900..970
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat1"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     1; cd09562"
                     /db_xref="CDD:188961"
     Region          988..1053
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat2"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     2; cd09565"
                     /db_xref="CDD:188964"
     Region          1073..1144
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat3"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     3; cd09568"
                     /db_xref="CDD:188967"
     CDS             1..1217
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /coded_by="XM_054370294.1:226..3879"
                     /db_xref="GeneID:8500"
                     /db_xref="HGNC:HGNC:9245"
                     /db_xref="MIM:611054"
ORIGIN      
        1 mmcevmptis eaegppgggg ghgsgspsqp dadshfeqlm vsmleerdrl ldtlretqet
       61 laltqgklhe vgherdslqr qlntalpqef aaltkelnvc reqllereee iaelkaernn
      121 trlllehlec lvsrherslr mtvvkrqaqs pagvssevev lkalkslfeh hkaldekvre
      181 rlrvalercs lleeelgath kelmilkeqn nqkktltdgv ldinheqent pstsgkrssd
      241 gslsheedla kvielqeiis kqsreqsqmk erlaslsshv teleedldta rkdlikseem
      301 ntklqrdvre amaqkedmee rittlekryl aaqreatsvh dlndklenei ankdsmhrqt
      361 edknrqlqer lelaeqklqq tlrkaetlpe veaelaqrva alsksdllss gssaakeakl
      421 leltsklrka eerhgnieer lrqmeaqlee knqelqrarq rekmneehnk rlsdtvdkll
      481 sesnerlqlh lkermaaled knsllreves akkqleetqh dkdqlvlnie alraeldhmr
      541 lrgaslhhgr phlgsvpdfr fpmadghtds ystsavlrrp qkgrlaalrd epskvqtlne
      601 qdweraqqas vlanvaqafe sdadvsdged drdtllssvd llspsgqada htlammlqeq
      661 ldainkeirl iqeekenteq raeeiesrvg sgsldnlgrf rsmssippyp asslassspp
      721 gsgrstprri phsparevdr lgvmtllpps reevrddktt ikcetsppss pralrldrlh
      781 kgalhtvshe dirdirnstg sqdgpvsnps ssnssqdslh kapkkkgiks sigrlfgkke
      841 kgrpgqtgke algqagvset dnssqdalgl sklggqaekn rklqkkhell eearrqglpf
      901 aqwdgptvvv wlelwvgmpa wyvaacranv ksgaimsals dteiqreigi snplhrlklr
      961 laiqeimslt spsapptsrt qtlaygdmnh ewignewlps lglpqyrsyf meclvdarml
     1021 dhltkkdlrg qlkmvdsfhr nsfqcgimcl rrlnydrkel erkreesqse ikdvlvwsnd
     1081 rvirwilsig lkeyannlie sgvhgallal detfdfsala lllqiptqnt qaravleref
     1141 nnllvmgtdr rfdedddksf rrapswrkkf rpkdirglaa gsaetlpanf rvtssmssps
     1201 mqpkkmqmdv yphyfyr
//
LOCUS       XP_054226270            1216 aa            linear   PRI 05-AUG-2025
DEFINITION  liprin-alpha-1 isoform X22 [Homo sapiens].
ACCESSION   XP_054226270
VERSION     XP_054226270.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370295.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1216
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1216
                     /product="liprin-alpha-1 isoform X22"
                     /calculated_mol_wt=137392
     Region          <45..687
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          <266..>548
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          900..970
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat1"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     1; cd09562"
                     /db_xref="CDD:188961"
     Region          987..1052
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat2"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     2; cd09565"
                     /db_xref="CDD:188964"
     Region          1072..1143
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat3"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     3; cd09568"
                     /db_xref="CDD:188967"
     CDS             1..1216
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /coded_by="XM_054370295.1:226..3876"
                     /db_xref="GeneID:8500"
                     /db_xref="HGNC:HGNC:9245"
                     /db_xref="MIM:611054"
ORIGIN      
        1 mmcevmptis eaegppgggg ghgsgspsqp dadshfeqlm vsmleerdrl ldtlretqet
       61 laltqgklhe vgherdslqr qlntalpqef aaltkelnvc reqllereee iaelkaernn
      121 trlllehlec lvsrherslr mtvvkrqaqs pagvssevev lkalkslfeh hkaldekvre
      181 rlrvalercs lleeelgath kelmilkeqn nqkktltdgv ldinheqent pstsgkrssd
      241 gslsheedla kvielqeiis kqsreqsqmk erlaslsshv teleedldta rkdlikseem
      301 ntklqrdvre amaqkedmee rittlekryl aaqreatsvh dlndklenei ankdsmhrqt
      361 edknrqlqer lelaeqklqq tlrkaetlpe veaelaqrva alsksdllss gssaakeakl
      421 leltsklrka eerhgnieer lrqmeaqlee knqelqrarq rekmneehnk rlsdtvdkll
      481 sesnerlqlh lkermaaled knsllreves akkqleetqh dkdqlvlnie alraeldhmr
      541 lrgaslhhgr phlgsvpdfr fpmadghtds ystsavlrrp qkgrlaalrd epskvqtlne
      601 qdweraqqas vlanvaqafe sdadvsdged drdtllssvd llspsgqada htlammlqeq
      661 ldainkeirl iqeekenteq raeeiesrvg sgsldnlgrf rsmssippyp asslassspp
      721 gsgrstprri phsparevdr lgvmtllpps reevrddktt ikcetsppss pralrldrlh
      781 kgalhtvshe dirdirnstg sqdgpvsnps ssnssqdslh kapkkkgiks sigrlfgkke
      841 kgrpgqtgke algqagvset dnssqdalgl sklggqaekn rklqkkhell eearrqglpf
      901 aqwdgptvvv wlelwvgmpa wyvaacranv ksgaimsals dteiqreigi snplhrlklr
      961 laiqeimslt spsapptsrt tlaygdmnhe wignewlpsl glpqyrsyfm eclvdarmld
     1021 hltkkdlrgq lkmvdsfhrn sfqcgimclr rlnydrkele rkreesqsei kdvlvwsndr
     1081 virwilsigl keyannlies gvhgallald etfdfsalal llqiptqntq aravlerefn
     1141 nllvmgtdrr fdedddksfr rapswrkkfr pkdirglaag saetlpanfr vtssmsspsm
     1201 qpkkmqmdvy phyfyr
//
LOCUS       XP_054226271            1212 aa            linear   PRI 05-AUG-2025
DEFINITION  liprin-alpha-1 isoform X23 [Homo sapiens].
ACCESSION   XP_054226271
VERSION     XP_054226271.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370296.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 37% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1212
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1212
                     /product="liprin-alpha-1 isoform X23"
                     /calculated_mol_wt=136923
     Region          <45..662
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          <243..>523
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          885..955
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat1"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     1; cd09562"
                     /db_xref="CDD:188961"
     Region          972..1037
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat2"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     2; cd09565"
                     /db_xref="CDD:188964"
     Region          1057..1128
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat3"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     3; cd09568"
                     /db_xref="CDD:188967"
     CDS             1..1212
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /coded_by="XM_054370296.1:226..3864"
                     /db_xref="GeneID:8500"
                     /db_xref="HGNC:HGNC:9245"
                     /db_xref="MIM:611054"
ORIGIN      
        1 mmcevmptis eaegppgggg ghgsgspsqp dadshfeqlm vsmleerdrl ldtlretqet
       61 laltqgklhe vgherdslqr qlntalpqef aaltkelnvc reqllereee iaelkaernn
      121 trlllehlec lvsrherslr mtvvkrqaqs pagvssevev lkalkslfeh hkaldekvre
      181 rlrvalercs lleeelgath kelmilkeqn nqkktltdgv ldinheqent pstsgkrssd
      241 gslsheedla kvielqeiis kqsreqsqmk erlaslsshv teleedldta rkdlikseem
      301 ntklqrdvre amaqkedmee rittlekryl aaqreatsvh dlndklenei ankdsmhrqt
      361 edknrqlqer lelaeqklqq tlrkaetlpe veaelaqrva alskaeerhg nieerlrqme
      421 aqleeknqel qrarqrekmn eehnkrlsdt vdkllsesne rlqlhlkerm aaledknsll
      481 revesakkql eetqhdkdql vlniealrae ldhmrlrgas lhhgrphlgs vpdfrfpmad
      541 ghtdsystsa vlrrpqkgrl aalrdepskv qtlneqdwer aqqasvlanv aqafesdadv
      601 sdgeddrdtl lssvdllsps gqadahtlam mlqeqldain keirliqeek enteqraeei
      661 esrvgsgsld nlgrfrsmss ippypassla sssppgsgrs tprriphspa revdrlgvmt
      721 lpsdlrkhrr klppsreevr ddkttikcet sppsspralr ldrlhkgalh tvshedirdi
      781 rnstgsqdgp vsnpsssnss qdslhkapkk kgikssigrl fgkkekgrpg qtgkealgqa
      841 gvsetdnssq dalglsklgg qaeknrklqk khelleearr qglpfaqwdg ptvvvwlelw
      901 vgmpawyvaa cranvksgai msalsdteiq reigisnplh rlklrlaiqe imsltspsap
      961 ptsrttlayg dmnhewigne wlpslglpqy rsyfmeclvd armldhltkk dlrgqlkmvd
     1021 sfhrnsfqcg imclrrlnyd rkelerkree sqseikdvlv wsndrvirwi lsiglkeyan
     1081 nliesgvhga llaldetfdf salalllqip tqntqaravl erefnnllvm gtdrrfdedd
     1141 dksfrrapsw rkkfrpkdir glaagsaetl panfrvtssm sspsmqpkkm qmdgnvsgtq
     1201 rldsatvrty sc
//
LOCUS       XP_054226272            1203 aa            linear   PRI 05-AUG-2025
DEFINITION  liprin-alpha-1 isoform X24 [Homo sapiens].
ACCESSION   XP_054226272
VERSION     XP_054226272.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370297.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 37% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1203
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1203
                     /product="liprin-alpha-1 isoform X24"
                     /calculated_mol_wt=135776
     Region          <45..662
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          <243..>523
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          875..945
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat1"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     1; cd09562"
                     /db_xref="CDD:188961"
     Region          963..1028
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat2"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     2; cd09565"
                     /db_xref="CDD:188964"
     Region          1048..1119
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat3"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     3; cd09568"
                     /db_xref="CDD:188967"
     CDS             1..1203
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /coded_by="XM_054370297.1:226..3837"
                     /db_xref="GeneID:8500"
                     /db_xref="HGNC:HGNC:9245"
                     /db_xref="MIM:611054"
ORIGIN      
        1 mmcevmptis eaegppgggg ghgsgspsqp dadshfeqlm vsmleerdrl ldtlretqet
       61 laltqgklhe vgherdslqr qlntalpqef aaltkelnvc reqllereee iaelkaernn
      121 trlllehlec lvsrherslr mtvvkrqaqs pagvssevev lkalkslfeh hkaldekvre
      181 rlrvalercs lleeelgath kelmilkeqn nqkktltdgv ldinheqent pstsgkrssd
      241 gslsheedla kvielqeiis kqsreqsqmk erlaslsshv teleedldta rkdlikseem
      301 ntklqrdvre amaqkedmee rittlekryl aaqreatsvh dlndklenei ankdsmhrqt
      361 edknrqlqer lelaeqklqq tlrkaetlpe veaelaqrva alskaeerhg nieerlrqme
      421 aqleeknqel qrarqrekmn eehnkrlsdt vdkllsesne rlqlhlkerm aaledknsll
      481 revesakkql eetqhdkdql vlniealrae ldhmrlrgas lhhgrphlgs vpdfrfpmad
      541 ghtdsystsa vlrrpqkgrl aalrdepskv qtlneqdwer aqqasvlanv aqafesdadv
      601 sdgeddrdtl lssvdllsps gqadahtlam mlqeqldain keirliqeek enteqraeei
      661 esrvgsgsld nlgrfrsmss ippypassla sssppgsgrs tprriphspa revdrlgvmt
      721 llppsreevr ddkttikcet sppsspralr ldrlhkgalh tvshedirdi rnstgsqdgp
      781 vsnpsssnss qdslhkapkk kgikssigrl fgkkekgrpg qtgkealgqa gvsetdnssq
      841 dalglsklgg qaeknrklqk khelleearr qglpfaqwdg ptvvvwlelw vgmpawyvaa
      901 cranvksgai msalsdteiq reigisnplh rlklrlaiqe imsltspsap ptsrtqtlay
      961 gdmnhewign ewlpslglpq yrsyfmeclv darmldhltk kdlrgqlkmv dsfhrnsfqc
     1021 gimclrrlny drkelerkre esqseikdvl vwsndrvirw ilsiglkeya nnliesgvhg
     1081 allaldetfd fsalalllqi ptqntqarav lerefnnllv mgtdrrfded ddksfrraps
     1141 wrkkfrpkdi rglaagsaet lpanfrvtss msspsmqpkk mqmdgnvsgt qrldsatvrt
     1201 ysc
//
LOCUS       XP_054226273            1191 aa            linear   PRI 05-AUG-2025
DEFINITION  liprin-alpha-1 isoform X25 [Homo sapiens].
ACCESSION   XP_054226273
VERSION     XP_054226273.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370298.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1191
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1191
                     /product="liprin-alpha-1 isoform X25"
                     /calculated_mol_wt=134777
     Region          <45..662
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          <243..>523
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          875..945
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat1"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     1; cd09562"
                     /db_xref="CDD:188961"
     Region          962..1027
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat2"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     2; cd09565"
                     /db_xref="CDD:188964"
     Region          1047..1118
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat3"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     3; cd09568"
                     /db_xref="CDD:188967"
     CDS             1..1191
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /coded_by="XM_054370298.1:226..3801"
                     /db_xref="GeneID:8500"
                     /db_xref="HGNC:HGNC:9245"
                     /db_xref="MIM:611054"
ORIGIN      
        1 mmcevmptis eaegppgggg ghgsgspsqp dadshfeqlm vsmleerdrl ldtlretqet
       61 laltqgklhe vgherdslqr qlntalpqef aaltkelnvc reqllereee iaelkaernn
      121 trlllehlec lvsrherslr mtvvkrqaqs pagvssevev lkalkslfeh hkaldekvre
      181 rlrvalercs lleeelgath kelmilkeqn nqkktltdgv ldinheqent pstsgkrssd
      241 gslsheedla kvielqeiis kqsreqsqmk erlaslsshv teleedldta rkdlikseem
      301 ntklqrdvre amaqkedmee rittlekryl aaqreatsvh dlndklenei ankdsmhrqt
      361 edknrqlqer lelaeqklqq tlrkaetlpe veaelaqrva alskaeerhg nieerlrqme
      421 aqleeknqel qrarqrekmn eehnkrlsdt vdkllsesne rlqlhlkerm aaledknsll
      481 revesakkql eetqhdkdql vlniealrae ldhmrlrgas lhhgrphlgs vpdfrfpmad
      541 ghtdsystsa vlrrpqkgrl aalrdepskv qtlneqdwer aqqasvlanv aqafesdadv
      601 sdgeddrdtl lssvdllsps gqadahtlam mlqeqldain keirliqeek enteqraeei
      661 esrvgsgsld nlgrfrsmss ippypassla sssppgsgrs tprriphspa revdrlgvmt
      721 llppsreevr ddkttikcet sppsspralr ldrlhkgalh tvshedirdi rnstgsqdgp
      781 vsnpsssnss qdslhkapkk kgikssigrl fgkkekgrpg qtgkealgqa gvsetdnssq
      841 dalglsklgg qaeknrklqk khelleearr qglpfaqwdg ptvvvwlelw vgmpawyvaa
      901 cranvksgai msalsdteiq reigisnplh rlklrlaiqe imsltspsap ptsrttlayg
      961 dmnhewigne wlpslglpqy rsyfmeclvd armldhltkk dlrgqlkmvd sfhrnsfqcg
     1021 imclrrlnyd rkelerkree sqseikdvlv wsndrvirwi lsiglkeyan nliesgvhga
     1081 llaldetfdf salalllqip tqntqaravl erefnnllvm gtdrrfdedd dksfrrapsw
     1141 rkkfrpkdir glaagsaetl panfrvtssm sspsmqpkkm qmdvyphyfy r
//
LOCUS       XP_054226274             742 aa            linear   PRI 05-AUG-2025
DEFINITION  liprin-alpha-1 isoform X26 [Homo sapiens].
ACCESSION   XP_054226274
VERSION     XP_054226274.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370299.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 9% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..742
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..742
                     /product="liprin-alpha-1 isoform X26"
                     /calculated_mol_wt=82274
     Region          385..455
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat1"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     1; cd09562"
                     /db_xref="CDD:188961"
     Region          502..567
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat2"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     2; cd09565"
                     /db_xref="CDD:188964"
     Region          587..658
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat3"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     3; cd09568"
                     /db_xref="CDD:188967"
     CDS             1..742
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /coded_by="XM_054370299.1:35..2263"
                     /db_xref="GeneID:8500"
                     /db_xref="HGNC:HGNC:9245"
                     /db_xref="MIM:611054"
ORIGIN      
        1 mgfrhagqvg lelltsgdhp pqppkmlglq vqtlneqdwe raqqasvlan vaqafesdad
       61 vsdgeddrdt llssvdllsp sgqadahtla mmlqeqldai nkeirliqee kenteqraee
      121 iesrvgsgsl dnlgrfrsms sippypassl asssppgsgr stprriphsp arevdrlgvm
      181 tlpspdsfli qtsgphqsvv ysstsppsst pcysdssqha qpsdlrkhrr klppsreevr
      241 ddkttikcet sppsspralr ldrlhkgalh tvshedirdi rnstgsqdgp vsnpsssnss
      301 qdslhkapkk kgikssigrl fgkkekgrpg qtgkealgqa gvsetdnssq dalglsklgg
      361 qaeknrklqk khelleearr qglpfaqwdg ptvvvwlelw vgmpawyvaa cranvksgai
      421 msalsdteiq reigisnplh rlklrlaiqe imsltspsap ptsrtttgnv wltheemetl
      481 aatpqtedee gswaqtlayg dmnhewigne wlpslglpqy rsyfmeclvd armldhltkk
      541 dlrgqlkmvd sfhrnsfqcg imclrrlnyd rkelerkree sqseikdvlv wsndrvirwi
      601 lsiglkeyan nliesgvhga llaldetfdf salalllqip tqntqaravl erefnnllvm
      661 gtdrrfdedd dksfrrapsw rkkfrpkdir glaagsaetl panfrvtssm sspsmqpkkm
      721 qmdgnvsgtq rldsatvrty sc
//
LOCUS       XP_054226275            1233 aa            linear   PRI 05-AUG-2025
DEFINITION  liprin-alpha-1 isoform X27 [Homo sapiens].
ACCESSION   XP_054226275
VERSION     XP_054226275.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370300.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 36% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1233
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1233
                     /product="liprin-alpha-1 isoform X27"
                     /calculated_mol_wt=139235
     Region          <45..662
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          <243..>523
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          885..955
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat1"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     1; cd09562"
                     /db_xref="CDD:188961"
     Region          993..1058
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat2"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     2; cd09565"
                     /db_xref="CDD:188964"
     Region          1078..1149
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat3"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     3; cd09568"
                     /db_xref="CDD:188967"
     CDS             1..1233
                     /gene="PPFIA1"
                     /gene_synonym="LIP.1; LIP1; LIPRIN"
                     /coded_by="XM_054370300.1:226..3927"
                     /db_xref="GeneID:8500"
                     /db_xref="HGNC:HGNC:9245"
                     /db_xref="MIM:611054"
ORIGIN      
        1 mmcevmptis eaegppgggg ghgsgspsqp dadshfeqlm vsmleerdrl ldtlretqet
       61 laltqgklhe vgherdslqr qlntalpqef aaltkelnvc reqllereee iaelkaernn
      121 trlllehlec lvsrherslr mtvvkrqaqs pagvssevev lkalkslfeh hkaldekvre
      181 rlrvalercs lleeelgath kelmilkeqn nqkktltdgv ldinheqent pstsgkrssd
      241 gslsheedla kvielqeiis kqsreqsqmk erlaslsshv teleedldta rkdlikseem
      301 ntklqrdvre amaqkedmee rittlekryl aaqreatsvh dlndklenei ankdsmhrqt
      361 edknrqlqer lelaeqklqq tlrkaetlpe veaelaqrva alskaeerhg nieerlrqme
      421 aqleeknqel qrarqrekmn eehnkrlsdt vdkllsesne rlqlhlkerm aaledknsll
      481 revesakkql eetqhdkdql vlniealrae ldhmrlrgas lhhgrphlgs vpdfrfpmad
      541 ghtdsystsa vlrrpqkgrl aalrdepskv qtlneqdwer aqqasvlanv aqafesdadv
      601 sdgeddrdtl lssvdllsps gqadahtlam mlqeqldain keirliqeek enteqraeei
      661 esrvgsgsld nlgrfrsmss ippypassla sssppgsgrs tprriphspa revdrlgvmt
      721 lpsdlrkhrr klppsreevr ddkttikcet sppsspralr ldrlhkgalh tvshedirdi
      781 rnstgsqdgp vsnpsssnss qdslhkapkk kgikssigrl fgkkekgrpg qtgkealgqa
      841 gvsetdnssq dalglsklgg qaeknrklqk khelleearr qglpfaqwdg ptvvvwlelw
      901 vgmpawyvaa cranvksgai msalsdteiq reigisnplh rlklrlaiqe imsltspsap
      961 ptsrtttgnv wltheemetl aatpqttlay gdmnhewign ewlpslglpq yrsyfmeclv
     1021 darmldhltk kdlrgqlkmv dsfhrnsfqc gimclrrlny drkelerkre esqseikdvl
     1081 vwsndrvirw ilsiglkeya nnliesgvhg allaldetfd fsalalllqi ptqntqarav
     1141 lerefnnllv mgtdrrfded ddksfrraps wrkkfrpkdi rglaagsaet lpanfrvtss
     1201 msspsmqpkk mqmdgnvsgt qrldsatvrt ysc
//
LOCUS       XP_054226276             575 aa            linear   PRI 05-AUG-2025
DEFINITION  large neutral amino acids transporter small subunit 3 isoform X1
            [Homo sapiens].
ACCESSION   XP_054226276
VERSION     XP_054226276.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370301.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..575
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..575
                     /product="large neutral amino acids transporter small
                     subunit 3 isoform X1"
                     /calculated_mol_wt=63055
     Region          91..>255
                     /region_name="FucP"
                     /note="Fucose permease [Carbohydrate transport and
                     metabolism]; COG0738"
                     /db_xref="CDD:440501"
     CDS             1..575
                     /gene="SLC43A1"
                     /gene_synonym="LAT3; PB39; POV1; R00504"
                     /coded_by="XM_054370301.1:327..2054"
                     /db_xref="GeneID:8501"
                     /db_xref="HGNC:HGNC:9225"
                     /db_xref="MIM:603733"
ORIGIN      
        1 mripsppgrs dwlgasmapt lqqayrrrww mactavlenl ffsavllgwg slliilkneg
       61 fysstcpaes stnttqdeqr rwpgcdqqde mlnlgftigs fvlsattlpl gilmdrfgpr
      121 pvrlvgsacf tasctlmala srdvealspl iflalslngf ggicltftsl tlpnmfgnlr
      181 stlmalmigs yassaitfpg ikliydagva fvvimftwsg lacliflnct lnwpieafpa
      241 peevnytkki klsglaldhk vtgdlfythv ttmgqrlsqk apsledgsda fmspqdvrgt
      301 senlpersvp lrkslcsptf lwslltmgmt qlriifymaa vnkmleylvt ggqehetneq
      361 qqkvaetvgf yssvfgamql lclltcplig yimdwrikdc vdaptqgtvl gdardgvatk
      421 sirpryckiq kltnaisaft ltnlllvgfg itclinnlhl qfvtfvlhti vrgffhsacg
      481 slyaavfpsn hfgtltglqs lisavfallq qplfmamvgp lkgepfwvnl glllfsllgf
      541 llpsylfyyr arlqqeyaan gmgplkvlsg sevta
//
LOCUS       XP_054226277             544 aa            linear   PRI 05-AUG-2025
DEFINITION  large neutral amino acids transporter small subunit 3 isoform X2
            [Homo sapiens].
ACCESSION   XP_054226277
VERSION     XP_054226277.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370302.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..544
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..544
                     /product="large neutral amino acids transporter small
                     subunit 3 isoform X2"
                     /calculated_mol_wt=59770
     Region          94..>185
                     /region_name="NarK"
                     /note="Nitrate/nitrite transporter NarK [Inorganic ion
                     transport and metabolism]; COG2223"
                     /db_xref="CDD:441825"
     CDS             1..544
                     /gene="SLC43A1"
                     /gene_synonym="LAT3; PB39; POV1; R00504"
                     /coded_by="XM_054370302.1:327..1961"
                     /db_xref="GeneID:8501"
                     /db_xref="HGNC:HGNC:9225"
                     /db_xref="MIM:603733"
ORIGIN      
        1 mripsppgrs dwlgasmapt lqqayrrrww mactavlenl ffsavllgwg slliilkneg
       61 fysstcpaes stnttqdeqr rwpgcdqqde mlnlgftigs fvlsattlpl gilmdrfgpr
      121 pvrlvgsacf tasctlmala srdvealspl iflalslngf ggicltftsl tliydagvaf
      181 vvimftwsgl acliflnctl nwpieafpap eevnytkkik lsglaldhkv tgdlfythvt
      241 tmgqrlsqka psledgsdaf mspqdvrgts enlpersvpl rkslcsptfl wslltmgmtq
      301 lriifymaav nkmleylvtg gqehetneqq qkvaetvgfy ssvfgamqll clltcpligy
      361 imdwrikdcv daptqgtvlg dardgvatks irpryckiqk ltnaisaftl tnlllvgfgi
      421 tclinnlhlq fvtfvlhtiv rgffhsacgs lyaavfpsnh fgtltglqsl isavfallqq
      481 plfmamvgpl kgepfwvnlg lllfsllgfl lpsylfyyra rlqqeyaang mgplkvlsgs
      541 evta
//
LOCUS       XP_054226278             528 aa            linear   PRI 05-AUG-2025
DEFINITION  large neutral amino acids transporter small subunit 3 isoform X3
            [Homo sapiens].
ACCESSION   XP_054226278
VERSION     XP_054226278.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370303.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..528
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..528
                     /product="large neutral amino acids transporter small
                     subunit 3 isoform X3"
                     /calculated_mol_wt=58061
     Region          78..>169
                     /region_name="NarK"
                     /note="Nitrate/nitrite transporter NarK [Inorganic ion
                     transport and metabolism]; COG2223"
                     /db_xref="CDD:441825"
     CDS             1..528
                     /gene="SLC43A1"
                     /gene_synonym="LAT3; PB39; POV1; R00504"
                     /coded_by="XM_054370303.1:273..1859"
                     /db_xref="GeneID:8501"
                     /db_xref="HGNC:HGNC:9225"
                     /db_xref="MIM:603733"
ORIGIN      
        1 maptlqqayr rrwwmactav lenlffsavl lgwgslliil knegfysstc paesstnttq
       61 deqrrwpgcd qqdemlnlgf tigsfvlsat tlplgilmdr fgprpvrlvg sacftasctl
      121 malasrdvea lspliflals lngfggiclt ftsltliyda gvafvvimft wsglaclifl
      181 nctlnwpiea fpapeevnyt kkiklsglal dhkvtgdlfy thvttmgqrl sqkapsledg
      241 sdafmspqdv rgtsenlper svplrkslcs ptflwslltm gmtqlriify maavnkmley
      301 lvtggqehet neqqqkvaet vgfyssvfga mqllclltcp ligyimdwri kdcvdaptqg
      361 tvlgdardgv atksirpryc kiqkltnais aftltnlllv gfgitclinn lhlqfvtfvl
      421 htivrgffhs acgslyaavf psnhfgtltg lqslisavfa llqqplfmam vgplkgepfw
      481 vnlglllfsl lgfllpsylf yyrarlqqey aangmgplkv lsgsevta
//
LOCUS       XP_054226279             528 aa            linear   PRI 05-AUG-2025
DEFINITION  large neutral amino acids transporter small subunit 3 isoform X3
            [Homo sapiens].
ACCESSION   XP_054226279
VERSION     XP_054226279.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370304.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..528
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..528
                     /product="large neutral amino acids transporter small
                     subunit 3 isoform X3"
                     /calculated_mol_wt=58061
     Region          78..>169
                     /region_name="NarK"
                     /note="Nitrate/nitrite transporter NarK [Inorganic ion
                     transport and metabolism]; COG2223"
                     /db_xref="CDD:441825"
     CDS             1..528
                     /gene="SLC43A1"
                     /gene_synonym="LAT3; PB39; POV1; R00504"
                     /coded_by="XM_054370304.1:143..1729"
                     /db_xref="GeneID:8501"
                     /db_xref="HGNC:HGNC:9225"
                     /db_xref="MIM:603733"
ORIGIN      
        1 maptlqqayr rrwwmactav lenlffsavl lgwgslliil knegfysstc paesstnttq
       61 deqrrwpgcd qqdemlnlgf tigsfvlsat tlplgilmdr fgprpvrlvg sacftasctl
      121 malasrdvea lspliflals lngfggiclt ftsltliyda gvafvvimft wsglaclifl
      181 nctlnwpiea fpapeevnyt kkiklsglal dhkvtgdlfy thvttmgqrl sqkapsledg
      241 sdafmspqdv rgtsenlper svplrkslcs ptflwslltm gmtqlriify maavnkmley
      301 lvtggqehet neqqqkvaet vgfyssvfga mqllclltcp ligyimdwri kdcvdaptqg
      361 tvlgdardgv atksirpryc kiqkltnais aftltnlllv gfgitclinn lhlqfvtfvl
      421 htivrgffhs acgslyaavf psnhfgtltg lqslisavfa llqqplfmam vgplkgepfw
      481 vnlglllfsl lgfllpsylf yyrarlqqey aangmgplkv lsgsevta
//
LOCUS       XP_054226280             485 aa            linear   PRI 05-AUG-2025
DEFINITION  large neutral amino acids transporter small subunit 3 isoform X4
            [Homo sapiens].
ACCESSION   XP_054226280
VERSION     XP_054226280.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370305.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..485
                     /product="large neutral amino acids transporter small
                     subunit 3 isoform X4"
                     /calculated_mol_wt=52845
     Region          1..>165
                     /region_name="FucP"
                     /note="Fucose permease [Carbohydrate transport and
                     metabolism]; COG0738"
                     /db_xref="CDD:440501"
     CDS             1..485
                     /gene="SLC43A1"
                     /gene_synonym="LAT3; PB39; POV1; R00504"
                     /coded_by="XM_054370305.1:199..1656"
                     /db_xref="GeneID:8501"
                     /db_xref="HGNC:HGNC:9225"
                     /db_xref="MIM:603733"
ORIGIN      
        1 mlnlgftigs fvlsattlpl gilmdrfgpr pvrlvgsacf tasctlmala srdvealspl
       61 iflalslngf ggicltftsl tlpnmfgnlr stlmalmigs yassaitfpg ikliydagva
      121 fvvimftwsg lacliflnct lnwpieafpa peevnytkki klsglaldhk vtgdlfythv
      181 ttmgqrlsqk apsledgsda fmspqdvrgt senlpersvp lrkslcsptf lwslltmgmt
      241 qlriifymaa vnkmleylvt ggqehetneq qqkvaetvgf yssvfgamql lclltcplig
      301 yimdwrikdc vdaptqgtvl gdardgvatk sirpryckiq kltnaisaft ltnlllvgfg
      361 itclinnlhl qfvtfvlhti vrgffhsacg slyaavfpsn hfgtltglqs lisavfallq
      421 qplfmamvgp lkgepfwvnl glllfsllgf llpsylfyyr arlqqeyaan gmgplkvlsg
      481 sevta
//
LOCUS       XP_054226282             125 aa            linear   PRI 05-AUG-2025
DEFINITION  interferon-induced transmembrane protein 1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_054226282
VERSION     XP_054226282.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370307.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..125
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..125
                     /product="interferon-induced transmembrane protein 1
                     isoform X1"
                     /calculated_mol_wt=13807
     Region          34..98
                     /region_name="CD225"
                     /note="Interferon-induced transmembrane protein;
                     pfam04505"
                     /db_xref="CDD:461336"
     CDS             1..125
                     /gene="IFITM1"
                     /gene_synonym="9-27; CD225; DSPA2a; IFI17; LEU13"
                     /coded_by="XM_054370307.1:2440..2817"
                     /db_xref="GeneID:8519"
                     /db_xref="HGNC:HGNC:5412"
                     /db_xref="MIM:604456"
ORIGIN      
        1 mhkeehevav lgappstilp rstvinihse tsvpdhvvws lfntlflnwc clgfiafays
       61 vksrdrkmvg dvtgaqayas takclniwal ilgilmtigf illlvfgsvt vyhimlqiiq
      121 ekrgy
//
LOCUS       XP_054226283             252 aa            linear   PRI 05-AUG-2025
DEFINITION  galectin-12 isoform X1 [Homo sapiens].
ACCESSION   XP_054226283
VERSION     XP_054226283.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370308.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..252
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..252
                     /product="galectin-12 isoform X1"
                     /calculated_mol_wt=27951
     Site            order(49..53,177..181)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:238025"
     Site            49..53
                     /site_type="active"
                     /note="dimerization swap strand [active]"
                     /db_xref="CDD:238025"
     Region          55..181
                     /region_name="Gal-bind_lectin"
                     /note="Galactoside-binding lectin; smart00908"
                     /db_xref="CDD:214904"
     Site            order(58..60,63,66,140..142,147,149,152)
                     /site_type="other"
                     /note="putative alternate dimerization interface
                     [polypeptide binding]"
                     /db_xref="CDD:238025"
     Site            order(96,98,100,109,111,118,121,123)
                     /site_type="other"
                     /note="sugar binding pocket [chemical binding]"
                     /db_xref="CDD:238025"
     CDS             1..252
                     /gene="LGALS12"
                     /gene_synonym="GAL12; GRIP1"
                     /coded_by="XM_054370308.1:310..1068"
                     /db_xref="GeneID:85329"
                     /db_xref="HGNC:HGNC:15788"
                     /db_xref="MIM:606096"
ORIGIN      
        1 msqpsggrap gtriyswscp tvmspgekld pipdsfilqp pvfhpvvpyv ttifgglhag
       61 kmvmlqgvvp ldahsrfqvd fqcgcslcpr pdiafhfnpr fhttkphvic ntlhggrwqr
      121 earwphlalr rgssflilfl fgneevkvsv ngqhflhfry rlplshvdtl gifgdilvea
      181 vgflninpfv egsreypagh pfllmsprle vpcshalpqg lspgqviivr glvlqepkqd
      241 slrccscsrr eg
//
LOCUS       XP_054226284             240 aa            linear   PRI 05-AUG-2025
DEFINITION  galectin-12 isoform X2 [Homo sapiens].
ACCESSION   XP_054226284
VERSION     XP_054226284.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370309.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..240
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..240
                     /product="galectin-12 isoform X2"
                     /calculated_mol_wt=26643
     Site            order(49..53,177..181)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:238025"
     Site            49..53
                     /site_type="active"
                     /note="dimerization swap strand [active]"
                     /db_xref="CDD:238025"
     Region          55..181
                     /region_name="Gal-bind_lectin"
                     /note="Galactoside-binding lectin; smart00908"
                     /db_xref="CDD:214904"
     Site            order(58..60,63,66,140..142,147,149,152)
                     /site_type="other"
                     /note="putative alternate dimerization interface
                     [polypeptide binding]"
                     /db_xref="CDD:238025"
     Site            order(96,98,100,109,111,118,121,123)
                     /site_type="other"
                     /note="sugar binding pocket [chemical binding]"
                     /db_xref="CDD:238025"
     CDS             1..240
                     /gene="LGALS12"
                     /gene_synonym="GAL12; GRIP1"
                     /coded_by="XM_054370309.1:310..1032"
                     /db_xref="GeneID:85329"
                     /db_xref="HGNC:HGNC:15788"
                     /db_xref="MIM:606096"
ORIGIN      
        1 msqpsggrap gtriyswscp tvmspgekld pipdsfilqp pvfhpvvpyv ttifgglhag
       61 kmvmlqgvvp ldahsrfqvd fqcgcslcpr pdiafhfnpr fhttkphvic ntlhggrwqr
      121 earwphlalr rgssflilfl fgneevkvsv ngqhflhfry rlplshvdtl gifgdilvea
      181 vgflninpfv egsreypagh pfllmsprle vpcshalpqg lspgqviivr glvlqepkhh
//
LOCUS       XP_054226285             432 aa            linear   PRI 05-AUG-2025
DEFINITION  carbohydrate sulfotransferase 1 isoform X1 [Homo sapiens].
ACCESSION   XP_054226285
VERSION     XP_054226285.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370310.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..432
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..432
                     /product="carbohydrate sulfotransferase 1 isoform X1"
                     /calculated_mol_wt=48575
     Region          <200..384
                     /region_name="Sulfotransfer_1"
                     /note="Sulfotransferase domain; cl21551"
                     /db_xref="CDD:473908"
     CDS             1..432
                     /gene="CHST1"
                     /gene_synonym="C6ST; GST-1; KS6ST; KSGal6ST; KSST"
                     /coded_by="XM_054370310.1:672..1970"
                     /db_xref="GeneID:8534"
                     /db_xref="HGNC:HGNC:1969"
                     /db_xref="MIM:603797"
ORIGIN      
        1 mqcswkavll lalasiaiqy tairtftaks fhtcpglaea glaerlcees ptfaynlsrk
       61 thililattr sgssfvgqlf nqhldvfylf eplyhvqntl iprftqgksp adrrvmlgas
      121 rdllrslydc dlyflenyik pppvnhttdr ifrrgasrvl csrpvcdppg padlvleegd
      181 cvrkcgllnl tvaaeacrer shvaiktvrv pevndlralv edprlnlkvi qlvrdprgil
      241 asrsetfrdt yrlwrlwygt grkpynldvt qlttvcedfs nsvstglmrp pwlkgkymlv
      301 ryedlarnpm kkteeiygfl gipldshvar wiqnntrgdp tlgkhkygtv rnsaataekw
      361 rfrlsydiva faqnacqqvl aqlgykiaas eeelknpssv vmlsvclslv aapgpvmtde
      421 syellidlgv hl
//
LOCUS       XP_054226286             432 aa            linear   PRI 05-AUG-2025
DEFINITION  carbohydrate sulfotransferase 1 isoform X1 [Homo sapiens].
ACCESSION   XP_054226286
VERSION     XP_054226286.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370311.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..432
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..432
                     /product="carbohydrate sulfotransferase 1 isoform X1"
                     /calculated_mol_wt=48575
     Region          <200..384
                     /region_name="Sulfotransfer_1"
                     /note="Sulfotransferase domain; cl21551"
                     /db_xref="CDD:473908"
     CDS             1..432
                     /gene="CHST1"
                     /gene_synonym="C6ST; GST-1; KS6ST; KSGal6ST; KSST"
                     /coded_by="XM_054370311.1:678..1976"
                     /db_xref="GeneID:8534"
                     /db_xref="HGNC:HGNC:1969"
                     /db_xref="MIM:603797"
ORIGIN      
        1 mqcswkavll lalasiaiqy tairtftaks fhtcpglaea glaerlcees ptfaynlsrk
       61 thililattr sgssfvgqlf nqhldvfylf eplyhvqntl iprftqgksp adrrvmlgas
      121 rdllrslydc dlyflenyik pppvnhttdr ifrrgasrvl csrpvcdppg padlvleegd
      181 cvrkcgllnl tvaaeacrer shvaiktvrv pevndlralv edprlnlkvi qlvrdprgil
      241 asrsetfrdt yrlwrlwygt grkpynldvt qlttvcedfs nsvstglmrp pwlkgkymlv
      301 ryedlarnpm kkteeiygfl gipldshvar wiqnntrgdp tlgkhkygtv rnsaataekw
      361 rfrlsydiva faqnacqqvl aqlgykiaas eeelknpssv vmlsvclslv aapgpvmtde
      421 syellidlgv hl
//
LOCUS       XP_054226287             411 aa            linear   PRI 05-AUG-2025
DEFINITION  carbohydrate sulfotransferase 1 isoform X2 [Homo sapiens].
ACCESSION   XP_054226287
VERSION     XP_054226287.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370312.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..411
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..411
                     /product="carbohydrate sulfotransferase 1 isoform X2"
                     /calculated_mol_wt=46584
     Region          <200..384
                     /region_name="Sulfotransfer_1"
                     /note="Sulfotransferase domain; cl21551"
                     /db_xref="CDD:473908"
     CDS             1..411
                     /gene="CHST1"
                     /gene_synonym="C6ST; GST-1; KS6ST; KSGal6ST; KSST"
                     /coded_by="XM_054370312.1:1111..2346"
                     /db_xref="GeneID:8534"
                     /db_xref="HGNC:HGNC:1969"
                     /db_xref="MIM:603797"
ORIGIN      
        1 mqcswkavll lalasiaiqy tairtftaks fhtcpglaea glaerlcees ptfaynlsrk
       61 thililattr sgssfvgqlf nqhldvfylf eplyhvqntl iprftqgksp adrrvmlgas
      121 rdllrslydc dlyflenyik pppvnhttdr ifrrgasrvl csrpvcdppg padlvleegd
      181 cvrkcgllnl tvaaeacrer shvaiktvrv pevndlralv edprlnlkvi qlvrdprgil
      241 asrsetfrdt yrlwrlwygt grkpynldvt qlttvcedfs nsvstglmrp pwlkgkymlv
      301 ryedlarnpm kkteeiygfl gipldshvar wiqnntrgdp tlgkhkygtv rnsaataekw
      361 rfrlsydiva faqnacqqvl aqlgykiaas eeelknpsvs lveerdfrpf s
//
LOCUS       XP_054226288             493 aa            linear   PRI 05-AUG-2025
DEFINITION  tripartite motif-containing protein 5 isoform X1 [Homo sapiens].
ACCESSION   XP_054226288
VERSION     XP_054226288.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370313.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..493
                     /product="tripartite motif-containing protein 5 isoform
                     X1"
                     /calculated_mol_wt=56233
     Region          7..78
                     /region_name="RING-HC_TRIM5-like_C-IV"
                     /note="RING finger, HC subclass, found in tripartite
                     motif-containing proteins TRIM5, TRIM6, TRIM22, TRIM34 and
                     similar proteins; cd16591"
                     /db_xref="CDD:438253"
     Site            order(16..17,19..20,56..57,59)
                     /site_type="other"
                     /note="E2 binding site [polypeptide binding]"
                     /db_xref="CDD:438253"
     Region          93..132
                     /region_name="Bbox2_TRIM5-like"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34,
                     TRIM38 and similar proteins; cd19761"
                     /db_xref="CDD:380819"
     Region          <130..>240
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          <130..175
                     /region_name="TMF_TATA_bd"
                     /note="TATA element modulatory factor 1 TATA binding;
                     pfam12325"
                     /db_xref="CDD:432481"
     Region          288..489
                     /region_name="SPRY_PRY_TRIM5"
                     /note="PRY/SPRY domain in tripartite motif-binding protein
                     5 (TRIM5), also known as RING finger protein 88 (RNF88);
                     cd15822"
                     /db_xref="CDD:293994"
     CDS             1..493
                     /gene="TRIM5"
                     /gene_synonym="RNF88; TRIM5alpha"
                     /coded_by="XM_054370313.1:121..1602"
                     /db_xref="GeneID:85363"
                     /db_xref="HGNC:HGNC:16276"
                     /db_xref="MIM:608487"
ORIGIN      
        1 masgilvnvk eevtcpicle lltqplsldc ghsfcqaclt anykksmldk gesscpvcri
       61 syqpenirpn rhvanivekl revklspegq kvdhcarhge klllfcqedg kvicwlcers
      121 qehrghhtfl teevareyqv klqaalemlr qkqqeaeele adireekasw ktqiqydktn
      181 vladfeqlrd ildweesnel qnlekeeedi lksltnsete mvqqtqslre lisdlehrlq
      241 gsvmellqgv dgvikrtenv tlkkpetfpk nqrrvfrapd lkgmlevfre ltdvrrywvd
      301 vtvapnnisc avisedkrqv sspkpqiiyg argtryqtfv nfnyctgilg sqsitsgkhy
      361 wevdvskkta wilgvcagfq pdamcniekn enyqpkygyw vigleegvkc safqdssfht
      421 psvpfivpls viicpdrvgv fldyeactvs ffnitnhgfl iykfshcsfs qpvfpylnpr
      481 kcgvpmtlcs pss
//
LOCUS       XP_054226289             326 aa            linear   PRI 05-AUG-2025
DEFINITION  tripartite motif-containing protein 5 isoform X2 [Homo sapiens].
ACCESSION   XP_054226289
VERSION     XP_054226289.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370314.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..326
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..326
                     /product="tripartite motif-containing protein 5 isoform
                     X2"
                     /calculated_mol_wt=37580
     Region          7..78
                     /region_name="RING-HC_TRIM5-like_C-IV"
                     /note="RING finger, HC subclass, found in tripartite
                     motif-containing proteins TRIM5, TRIM6, TRIM22, TRIM34 and
                     similar proteins; cd16591"
                     /db_xref="CDD:438253"
     Site            order(16..17,19..20,56..57,59)
                     /site_type="other"
                     /note="E2 binding site [polypeptide binding]"
                     /db_xref="CDD:438253"
     Region          93..132
                     /region_name="Bbox2_TRIM5-like"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34,
                     TRIM38 and similar proteins; cd19761"
                     /db_xref="CDD:380819"
     Region          <130..175
                     /region_name="TMF_TATA_bd"
                     /note="TATA element modulatory factor 1 TATA binding;
                     pfam12325"
                     /db_xref="CDD:432481"
     Region          <142..>255
                     /region_name="ClyA-like"
                     /note="family of the cytolysin A (ClyA) family alpha
                     pore-forming toxins (alpha-PFT) including Bacillus cereus
                     HblB, Aeromonas hydrophila AhlB, Bacillus thuringiensis
                     Cry6Aa and similar proteins; cl45899"
                     /db_xref="CDD:459244"
     CDS             1..326
                     /gene="TRIM5"
                     /gene_synonym="RNF88; TRIM5alpha"
                     /coded_by="XM_054370314.1:269..1249"
                     /db_xref="GeneID:85363"
                     /db_xref="HGNC:HGNC:16276"
                     /db_xref="MIM:608487"
ORIGIN      
        1 masgilvnvk eevtcpicle lltqplsldc ghsfcqaclt anykksmldk gesscpvcri
       61 syqpenirpn rhvanivekl revklspegq kvdhcarhge klllfcqedg kvicwlcers
      121 qehrghhtfl teevareyqv klqaalemlr qkqqeaeele adireekasw ktqiqydktn
      181 vladfeqlrd ildweesnel qnlekeeedi lksltnsete mvqqtqslre lisdlehrlq
      241 gsvmellqgv dgvikrtenv tlkkpetfpk nqrrvfrapd lkgmlevfre ltdvrrywgw
      301 samarsrfta tstsqiqail lpqppk
//
LOCUS       XP_054226290             314 aa            linear   PRI 05-AUG-2025
DEFINITION  tripartite motif-containing protein 5 isoform X3 [Homo sapiens].
ACCESSION   XP_054226290
VERSION     XP_054226290.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370315.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..314
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..314
                     /product="tripartite motif-containing protein 5 isoform
                     X3"
                     /calculated_mol_wt=36482
     Region          7..78
                     /region_name="RING-HC_TRIM5-like_C-IV"
                     /note="RING finger, HC subclass, found in tripartite
                     motif-containing proteins TRIM5, TRIM6, TRIM22, TRIM34 and
                     similar proteins; cd16591"
                     /db_xref="CDD:438253"
     Site            order(16..17,19..20,56..57,59)
                     /site_type="other"
                     /note="E2 binding site [polypeptide binding]"
                     /db_xref="CDD:438253"
     Region          93..132
                     /region_name="Bbox2_TRIM5-like"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34,
                     TRIM38 and similar proteins; cd19761"
                     /db_xref="CDD:380819"
     Region          <118..>240
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          <130..175
                     /region_name="TMF_TATA_bd"
                     /note="TATA element modulatory factor 1 TATA binding;
                     pfam12325"
                     /db_xref="CDD:432481"
     CDS             1..314
                     /gene="TRIM5"
                     /gene_synonym="RNF88; TRIM5alpha"
                     /coded_by="XM_054370315.1:269..1213"
                     /db_xref="GeneID:85363"
                     /db_xref="HGNC:HGNC:16276"
                     /db_xref="MIM:608487"
ORIGIN      
        1 masgilvnvk eevtcpicle lltqplsldc ghsfcqaclt anykksmldk gesscpvcri
       61 syqpenirpn rhvanivekl revklspegq kvdhcarhge klllfcqedg kvicwlcers
      121 qehrghhtfl teevareyqv klqaalemlr qkqqeaeele adireekasw ktqiqydktn
      181 vladfeqlrd ildweesnel qnlekeeedi lksltnsete mvqqtqslre lisdlehrlq
      241 gsvmellqrc ghamlprlyi clinqrstny lnhfmeshir leknklsvts fpskhvpsae
      301 trslfhrdes yfyf
//
LOCUS       XP_054226291             310 aa            linear   PRI 05-AUG-2025
DEFINITION  tripartite motif-containing protein 5 isoform X4 [Homo sapiens].
ACCESSION   XP_054226291
VERSION     XP_054226291.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370316.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..310
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..310
                     /product="tripartite motif-containing protein 5 isoform
                     X4"
                     /calculated_mol_wt=35130
     Region          7..78
                     /region_name="RING-HC_TRIM5-like_C-IV"
                     /note="RING finger, HC subclass, found in tripartite
                     motif-containing proteins TRIM5, TRIM6, TRIM22, TRIM34 and
                     similar proteins; cd16591"
                     /db_xref="CDD:438253"
     Site            order(16..17,19..20,56..57,59)
                     /site_type="other"
                     /note="E2 binding site [polypeptide binding]"
                     /db_xref="CDD:438253"
     Region          93..132
                     /region_name="Bbox2_TRIM5-like"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34,
                     TRIM38 and similar proteins; cd19761"
                     /db_xref="CDD:380819"
     Region          <130..175
                     /region_name="TMF_TATA_bd"
                     /note="TATA element modulatory factor 1 TATA binding;
                     pfam12325"
                     /db_xref="CDD:432481"
     Region          <142..>255
                     /region_name="ClyA-like"
                     /note="family of the cytolysin A (ClyA) family alpha
                     pore-forming toxins (alpha-PFT) including Bacillus cereus
                     HblB, Aeromonas hydrophila AhlB, Bacillus thuringiensis
                     Cry6Aa and similar proteins; cl45899"
                     /db_xref="CDD:459244"
     CDS             1..310
                     /gene="TRIM5"
                     /gene_synonym="RNF88; TRIM5alpha"
                     /coded_by="XM_054370316.1:269..1201"
                     /db_xref="GeneID:85363"
                     /db_xref="HGNC:HGNC:16276"
                     /db_xref="MIM:608487"
ORIGIN      
        1 masgilvnvk eevtcpicle lltqplsldc ghsfcqaclt anykksmldk gesscpvcri
       61 syqpenirpn rhvanivekl revklspegq kvdhcarhge klllfcqedg kvicwlcers
      121 qehrghhtfl teevareyqv klqaalemlr qkqqeaeele adireekasw ktqiqydktn
      181 vladfeqlrd ildweesnel qnlekeeedi lksltnsete mvqqtqslre lisdlehrlq
      241 gsvmellqgv dgvikradrc ptllglecng tisvhcnlhl sdssnspasa sqvagitgah
      301 hhpwlnlyfq
//
LOCUS       XP_054226292             310 aa            linear   PRI 05-AUG-2025
DEFINITION  tripartite motif-containing protein 5 isoform X4 [Homo sapiens].
ACCESSION   XP_054226292
VERSION     XP_054226292.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370317.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..310
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..310
                     /product="tripartite motif-containing protein 5 isoform
                     X4"
                     /calculated_mol_wt=35130
     Region          7..78
                     /region_name="RING-HC_TRIM5-like_C-IV"
                     /note="RING finger, HC subclass, found in tripartite
                     motif-containing proteins TRIM5, TRIM6, TRIM22, TRIM34 and
                     similar proteins; cd16591"
                     /db_xref="CDD:438253"
     Site            order(16..17,19..20,56..57,59)
                     /site_type="other"
                     /note="E2 binding site [polypeptide binding]"
                     /db_xref="CDD:438253"
     Region          93..132
                     /region_name="Bbox2_TRIM5-like"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34,
                     TRIM38 and similar proteins; cd19761"
                     /db_xref="CDD:380819"
     Region          <130..175
                     /region_name="TMF_TATA_bd"
                     /note="TATA element modulatory factor 1 TATA binding;
                     pfam12325"
                     /db_xref="CDD:432481"
     Region          <142..>255
                     /region_name="ClyA-like"
                     /note="family of the cytolysin A (ClyA) family alpha
                     pore-forming toxins (alpha-PFT) including Bacillus cereus
                     HblB, Aeromonas hydrophila AhlB, Bacillus thuringiensis
                     Cry6Aa and similar proteins; cl45899"
                     /db_xref="CDD:459244"
     CDS             1..310
                     /gene="TRIM5"
                     /gene_synonym="RNF88; TRIM5alpha"
                     /coded_by="XM_054370317.1:121..1053"
                     /db_xref="GeneID:85363"
                     /db_xref="HGNC:HGNC:16276"
                     /db_xref="MIM:608487"
ORIGIN      
        1 masgilvnvk eevtcpicle lltqplsldc ghsfcqaclt anykksmldk gesscpvcri
       61 syqpenirpn rhvanivekl revklspegq kvdhcarhge klllfcqedg kvicwlcers
      121 qehrghhtfl teevareyqv klqaalemlr qkqqeaeele adireekasw ktqiqydktn
      181 vladfeqlrd ildweesnel qnlekeeedi lksltnsete mvqqtqslre lisdlehrlq
      241 gsvmellqgv dgvikradrc ptllglecng tisvhcnlhl sdssnspasa sqvagitgah
      301 hhpwlnlyfq
//
LOCUS       XP_054226293             285 aa            linear   PRI 05-AUG-2025
DEFINITION  tripartite motif-containing protein 5 isoform X8 [Homo sapiens].
ACCESSION   XP_054226293
VERSION     XP_054226293.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370318.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..285
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..285
                     /product="tripartite motif-containing protein 5 isoform
                     X8"
                     /calculated_mol_wt=32737
     Region          7..78
                     /region_name="RING-HC_TRIM5-like_C-IV"
                     /note="RING finger, HC subclass, found in tripartite
                     motif-containing proteins TRIM5, TRIM6, TRIM22, TRIM34 and
                     similar proteins; cd16591"
                     /db_xref="CDD:438253"
     Site            order(16..17,19..20,56..57,59)
                     /site_type="other"
                     /note="E2 binding site [polypeptide binding]"
                     /db_xref="CDD:438253"
     Region          93..132
                     /region_name="Bbox2_TRIM5-like"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34,
                     TRIM38 and similar proteins; cd19761"
                     /db_xref="CDD:380819"
     Region          <130..>240
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          <130..175
                     /region_name="TMF_TATA_bd"
                     /note="TATA element modulatory factor 1 TATA binding;
                     pfam12325"
                     /db_xref="CDD:432481"
     CDS             1..285
                     /gene="TRIM5"
                     /gene_synonym="RNF88; TRIM5alpha"
                     /coded_by="XM_054370318.1:269..1126"
                     /db_xref="GeneID:85363"
                     /db_xref="HGNC:HGNC:16276"
                     /db_xref="MIM:608487"
ORIGIN      
        1 masgilvnvk eevtcpicle lltqplsldc ghsfcqaclt anykksmldk gesscpvcri
       61 syqpenirpn rhvanivekl revklspegq kvdhcarhge klllfcqedg kvicwlcers
      121 qehrghhtfl teevareyqv klqaalemlr qkqqeaeele adireekasw ktqiqydktn
      181 vladfeqlrd ildweesnel qnlekeeedi lksltnsete mvqqtqslre lisdlehrlq
      241 gsvmellqkt rcdeesschi wvkvsssgqr tggnvsrest yneqk
//
LOCUS       XP_054226294             278 aa            linear   PRI 05-AUG-2025
DEFINITION  tripartite motif-containing protein 5 isoform X5 [Homo sapiens].
ACCESSION   XP_054226294
VERSION     XP_054226294.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370319.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..278
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..278
                     /product="tripartite motif-containing protein 5 isoform
                     X5"
                     /calculated_mol_wt=31746
     Region          7..78
                     /region_name="RING-HC_TRIM5-like_C-IV"
                     /note="RING finger, HC subclass, found in tripartite
                     motif-containing proteins TRIM5, TRIM6, TRIM22, TRIM34 and
                     similar proteins; cd16591"
                     /db_xref="CDD:438253"
     Site            order(16..17,19..20,56..57,59)
                     /site_type="other"
                     /note="E2 binding site [polypeptide binding]"
                     /db_xref="CDD:438253"
     Region          93..132
                     /region_name="Bbox2_TRIM5-like"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34,
                     TRIM38 and similar proteins; cd19761"
                     /db_xref="CDD:380819"
     Region          <142..267
                     /region_name="ClyA-like"
                     /note="family of the cytolysin A (ClyA) family alpha
                     pore-forming toxins (alpha-PFT) including Bacillus cereus
                     HblB, Aeromonas hydrophila AhlB, Bacillus thuringiensis
                     Cry6Aa and similar proteins; cl45899"
                     /db_xref="CDD:459244"
     CDS             1..278
                     /gene="TRIM5"
                     /gene_synonym="RNF88; TRIM5alpha"
                     /coded_by="XM_054370319.1:121..957"
                     /db_xref="GeneID:85363"
                     /db_xref="HGNC:HGNC:16276"
                     /db_xref="MIM:608487"
ORIGIN      
        1 masgilvnvk eevtcpicle lltqplsldc ghsfcqaclt anykksmldk gesscpvcri
       61 syqpenirpn rhvanivekl revklspegq kvdhcarhge klllfcqedg kvicwlcers
      121 qehrghhtfl teevareyqv klqaalemlr qkqqeaeele adireekasw ktqiqydktn
      181 vladfeqlrd ildweesnel qnlekeeedi lksltnsete mvqqtqslre lisdlehrlq
      241 gsvmellqgv dgvikradrc ptllgrldvm kravvtsg
//
LOCUS       XP_054226295             271 aa            linear   PRI 05-AUG-2025
DEFINITION  tripartite motif-containing protein 5 isoform X9 [Homo sapiens].
ACCESSION   XP_054226295
VERSION     XP_054226295.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370320.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..271
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..271
                     /product="tripartite motif-containing protein 5 isoform
                     X9"
                     /calculated_mol_wt=31148
     Region          7..78
                     /region_name="RING-HC_TRIM5-like_C-IV"
                     /note="RING finger, HC subclass, found in tripartite
                     motif-containing proteins TRIM5, TRIM6, TRIM22, TRIM34 and
                     similar proteins; cd16591"
                     /db_xref="CDD:438253"
     Site            order(16..17,19..20,56..57,59)
                     /site_type="other"
                     /note="E2 binding site [polypeptide binding]"
                     /db_xref="CDD:438253"
     Region          93..132
                     /region_name="Bbox2_TRIM5-like"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34,
                     TRIM38 and similar proteins; cd19761"
                     /db_xref="CDD:380819"
     Region          <130..>259
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     CDS             1..271
                     /gene="TRIM5"
                     /gene_synonym="RNF88; TRIM5alpha"
                     /coded_by="XM_054370320.1:269..1084"
                     /db_xref="GeneID:85363"
                     /db_xref="HGNC:HGNC:16276"
                     /db_xref="MIM:608487"
ORIGIN      
        1 masgilvnvk eevtcpicle lltqplsldc ghsfcqaclt anykksmldk gesscpvcri
       61 syqpenirpn rhvanivekl revklspegq kvdhcarhge klllfcqedg kvicwlcers
      121 qehrghhtfl teevareyqv klqaalemlr qkqqeaeele adireekasw ktqiqydktn
      181 vladfeqlrd ildweesnel qnlekeeedi lksltnsete mvqqtqslre lisdlehrlq
      241 gsvmellqdg erdleearnf skkskesvss s
//
LOCUS       XP_054226296             265 aa            linear   PRI 05-AUG-2025
DEFINITION  tripartite motif-containing protein 5 isoform X6 [Homo sapiens].
ACCESSION   XP_054226296
VERSION     XP_054226296.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370321.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..265
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..265
                     /product="tripartite motif-containing protein 5 isoform
                     X6"
                     /calculated_mol_wt=30333
     Region          7..78
                     /region_name="RING-HC_TRIM5-like_C-IV"
                     /note="RING finger, HC subclass, found in tripartite
                     motif-containing proteins TRIM5, TRIM6, TRIM22, TRIM34 and
                     similar proteins; cd16591"
                     /db_xref="CDD:438253"
     Site            order(16..17,19..20,56..57,59)
                     /site_type="other"
                     /note="E2 binding site [polypeptide binding]"
                     /db_xref="CDD:438253"
     Region          93..132
                     /region_name="Bbox2_TRIM5-like"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34,
                     TRIM38 and similar proteins; cd19761"
                     /db_xref="CDD:380819"
     Region          <130..175
                     /region_name="TMF_TATA_bd"
                     /note="TATA element modulatory factor 1 TATA binding;
                     pfam12325"
                     /db_xref="CDD:432481"
     Region          <142..>255
                     /region_name="ClyA-like"
                     /note="family of the cytolysin A (ClyA) family alpha
                     pore-forming toxins (alpha-PFT) including Bacillus cereus
                     HblB, Aeromonas hydrophila AhlB, Bacillus thuringiensis
                     Cry6Aa and similar proteins; cl45899"
                     /db_xref="CDD:459244"
     CDS             1..265
                     /gene="TRIM5"
                     /gene_synonym="RNF88; TRIM5alpha"
                     /coded_by="XM_054370321.1:269..1066"
                     /db_xref="GeneID:85363"
                     /db_xref="HGNC:HGNC:16276"
                     /db_xref="MIM:608487"
ORIGIN      
        1 masgilvnvk eevtcpicle lltqplsldc ghsfcqaclt anykksmldk gesscpvcri
       61 syqpenirpn rhvanivekl revklspegq kvdhcarhge klllfcqedg kvicwlcers
      121 qehrghhtfl teevareyqv klqaalemlr qkqqeaeele adireekasw ktqiqydktn
      181 vladfeqlrd ildweesnel qnlekeeedi lksltnsete mvqqtqslre lisdlehrlq
      241 gsvmellqgv dgvikradrc ptllg
//
LOCUS       XP_054226297             233 aa            linear   PRI 05-AUG-2025
DEFINITION  homeobox protein BarH-like 2 isoform X1 [Homo sapiens].
ACCESSION   XP_054226297
VERSION     XP_054226297.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370322.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..233
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..233
                     /product="homeobox protein BarH-like 2 isoform X1"
                     /calculated_mol_wt=25819
     Region          88..144
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     CDS             1..233
                     /gene="BARX2"
                     /coded_by="XM_054370322.1:16..717"
                     /db_xref="GeneID:8538"
                     /db_xref="HGNC:HGNC:956"
                     /db_xref="MIM:604823"
ORIGIN      
        1 mhincledrm serkvsgsps lraypllsvi trqptvishl vpatpgiaqa lschqvteav
       61 saeapggeal asseseteqp tprqkkprrs rtiftelqlm glekkfqkqk ylstpdrldl
      121 aqslgltqlq vktwyqnrrm kwkkmvlkgg qeaptkpkgr pkknsiptse eieaeekmns
      181 qaqgqeqlep sqgqeelcea qepkardvpl emaeppdppq elpipssepp pls
//
LOCUS       XP_054226298             134 aa            linear   PRI 05-AUG-2025
DEFINITION  homeobox protein BarH-like 2 isoform X2 [Homo sapiens].
ACCESSION   XP_054226298
VERSION     XP_054226298.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370323.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..134
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..134
                     /product="homeobox protein BarH-like 2 isoform X2"
                     /calculated_mol_wt=15060
     Region          <3..45
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     CDS             1..134
                     /gene="BARX2"
                     /coded_by="XM_054370323.1:324..728"
                     /db_xref="GeneID:8538"
                     /db_xref="HGNC:HGNC:956"
                     /db_xref="MIM:604823"
ORIGIN      
        1 mglekkfqkq kylstpdrld laqslgltql qvktwyqnrr mkwkkmvlkg gqeaptkpkg
       61 rpkknsipts eeieaeekmn sqaqgqeqle psqgqeelce aqepkardvp lemaeppdpp
      121 qelpipssep ppls
//
LOCUS       XP_054226299             509 aa            linear   PRI 05-AUG-2025
DEFINITION  apoptosis inhibitor 5 isoform X1 [Homo sapiens].
ACCESSION   XP_054226299
VERSION     XP_054226299.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370324.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..509
                     /product="apoptosis inhibitor 5 isoform X1"
                     /calculated_mol_wt=57180
     Region          4..500
                     /region_name="API5"
                     /note="Apoptosis inhibitory protein 5 (API5); pfam05918"
                     /db_xref="CDD:428672"
     Region          63..91
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          97..139
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     CDS             1..509
                     /gene="API5"
                     /gene_synonym="AAC-11; AAC11"
                     /coded_by="XM_054370324.1:133..1662"
                     /db_xref="GeneID:8539"
                     /db_xref="HGNC:HGNC:594"
                     /db_xref="MIM:609774"
ORIGIN      
        1 mptveelyrn ygiladateq vgqhkdayqv ildgvkggtk ekrlaaqfip kffkhfpela
       61 dsainaqldl cededvsirr qaikelpqfa tgenlprvad iltqllqtdd saefnlvnna
      121 llsifkmdak gtlgglfsqi lqgedivrer aikflstklk tlpdevltke veeliltesk
      181 kvledvtgee fvlfmkilsg lkslqtvsgr qqlvelvaeq adleqtfnps dpdcvdrllq
      241 ctrqavplfs knvhstrfvt yfceqvlpnl gtlttpvegl diqlevlkll aemssfcgdm
      301 ekletnlrkl fdklleympl ppeeaengen agneepklqf syvecllysf hqlgrklpdf
      361 ltaklnaekl kdfkirlqyf arglqvyirq lrlalqgktg ealkteenki kvvalkitnn
      421 invlikdlfh ippsykstvt lswkpvqkve igqkrasedt tsgsppkkss agpkrdarqi
      481 ynppsgkyss nlgnfnyerg vkkdiktsp
//
LOCUS       XP_054226300            1729 aa            linear   PRI 05-AUG-2025
DEFINITION  182 kDa tankyrase-1-binding protein isoform X1 [Homo sapiens].
ACCESSION   XP_054226300
VERSION     XP_054226300.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370325.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1729
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1729
                     /product="182 kDa tankyrase-1-binding protein isoform X1"
                     /calculated_mol_wt=181648
     Region          <26..390
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          <273..691
                     /region_name="PRK07764"
                     /note="DNA polymerase III subunits gamma and tau;
                     Validated"
                     /db_xref="CDD:236090"
     Region          1556..1721
                     /region_name="Tankyrase_bdg_C"
                     /note="Tankyrase binding protein C terminal domain;
                     pfam15327"
                     /db_xref="CDD:464648"
     CDS             1..1729
                     /gene="TNKS1BP1"
                     /gene_synonym="CNOT12; TAB182"
                     /coded_by="XM_054370325.1:182..5371"
                     /db_xref="GeneID:85456"
                     /db_xref="HGNC:HGNC:19081"
                     /db_xref="MIM:607104"
ORIGIN      
        1 mkvstlress amasplprem eeelvptgse pgdtrakppv kpkpralpak palpakpsll
       61 vpvgprpprg plaelpsark mnmlagpqpy ggskrplpfa prpaveastg geatqetgke
      121 eagkeepppl tpparcaapg gvrkapapfr paserfaatt veeilakmeq prkevlaspd
      181 rlwgsrltfn hdgssrygpr tygtttaprd edgstlfrgw sqegpvkspa ecreehsktp
      241 eerslpsdla fngdlakaas selpadiskp wipsspapss enggpaspgl paeasgsgpg
      301 sphlhppdks spchsqllea qtpeasqasp cpavtpsaps aalpdegsrh tpspglpaeg
      361 apeaprpssp paevlephsl dqppatsprp lievgelldl trtfpsggee eakgdahlrp
      421 tslvqrrfse gvlqspsqdq eklggslaal pqgqgsqlal drpfgaesnw slsqsfewtf
      481 ptrpsglgvw rldspppspi teaseaaeaa eagnlavssr eegvsqqgqg agsapsgsgs
      541 swvqgddpsm sltqkgdges qpqfpavple plpttegtpg lplqqaeery esqeplagqe
      601 splslatrea alpilepvlg qeqpaapdqp cvlfadapep gqalpveeea vtlaraettq
      661 arteaqdlcr aspeppgpes ssrwlddlla spppsgggar rgagaelkdt qspstcsegl
      721 lgwsqkdlqs efgitgdpqp ssfspsswcq gasqdyglgg asprgdpglg erdwtskygq
      781 gagegstrew asrcgigqee measssqdqs kvsapgvlta qdrvvgkpaq lgtqrsqead
      841 vqdwefrkrd sqgtyssrda elqdqefgkr dslgtyssrd vslgdwefgk rdslgayasq
      901 daneqgqdlg krdhhgryss qdadeqdwef qkrdvslgty gsraaepqeq efgksawird
      961 yssggssrtl daqdrsfgtr plssgfspee aqqqdeefek kipsvedslg egsrdagrpg
     1021 ergsgglfsp stahvpdgal gqrdqsswqn sdasqevggh qerqqagaqg pgsadledge
     1081 mgkrgwvgef slsvgprrea afspgqqdws rdfcieaser syqfgiignd rvsgagfsps
     1141 skmegghfvp pgkttagsvd wtdqlglrnl evsscvgsgg ssearesavg qmgwsgglsl
     1201 rdmnltgcle sggseepggi gvgekdwtsd vnvkskdlae vgeggghsqa resgvgqtdw
     1261 sgveageflk srergvgqad wtpdlglrnm apgavcspge skelgvgqmd wgnnlglrdl
     1321 evtcdpdsgg sqglrgcgvg qmdwtqdlap qnvelfgaps earehgvggv sqcpepglrh
     1381 ngslspglea rdplearelg vgetsgpetq gedyssssle phpadpgmet gealsfgasp
     1441 grcparppps gsqglleeml aassskavar resaasglgg lleeegagag aaqeevlepg
     1501 rdsppswrpq pdgeasqted vdgtwgssaa rwsdqgpaqt srrpsqgppa rspsqdfsfi
     1561 edteildsam yrsranlgrk rghrapvirp ggtlglseaa dsdarlfqds teprasrvps
     1621 sdeevaeepq srrtrmslgt kglkvnlfpg lspsalkakl rprnrsaeeg elaeskssqk
     1681 esavqrsksc kvpglgkplt lppkpekssg segsspnwlq alklkkkkv
//
LOCUS       XP_054226301            1480 aa            linear   PRI 05-AUG-2025
DEFINITION  182 kDa tankyrase-1-binding protein isoform X2 [Homo sapiens].
ACCESSION   XP_054226301
VERSION     XP_054226301.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370326.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1480
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1480
                     /product="182 kDa tankyrase-1-binding protein isoform X2"
                     /calculated_mol_wt=155411
     Region          <26..390
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          <273..691
                     /region_name="PRK07764"
                     /note="DNA polymerase III subunits gamma and tau;
                     Validated"
                     /db_xref="CDD:236090"
     CDS             1..1480
                     /gene="TNKS1BP1"
                     /gene_synonym="CNOT12; TAB182"
                     /coded_by="XM_054370326.1:179..4621"
                     /db_xref="GeneID:85456"
                     /db_xref="HGNC:HGNC:19081"
                     /db_xref="MIM:607104"
ORIGIN      
        1 mkvstlress amasplprem eeelvptgse pgdtrakppv kpkpralpak palpakpsll
       61 vpvgprpprg plaelpsark mnmlagpqpy ggskrplpfa prpaveastg geatqetgke
      121 eagkeepppl tpparcaapg gvrkapapfr paserfaatt veeilakmeq prkevlaspd
      181 rlwgsrltfn hdgssrygpr tygtttaprd edgstlfrgw sqegpvkspa ecreehsktp
      241 eerslpsdla fngdlakaas selpadiskp wipsspapss enggpaspgl paeasgsgpg
      301 sphlhppdks spchsqllea qtpeasqasp cpavtpsaps aalpdegsrh tpspglpaeg
      361 apeaprpssp paevlephsl dqppatsprp lievgelldl trtfpsggee eakgdahlrp
      421 tslvqrrfse gvlqspsqdq eklggslaal pqgqgsqlal drpfgaesnw slsqsfewtf
      481 ptrpsglgvw rldspppspi teaseaaeaa eagnlavssr eegvsqqgqg agsapsgsgs
      541 swvqgddpsm sltqkgdges qpqfpavple plpttegtpg lplqqaeery esqeplagqe
      601 splslatrea alpilepvlg qeqpaapdqp cvlfadapep gqalpveeea vtlaraettq
      661 arteaqdlcr aspeppgpes ssrwlddlla spppsgggar rgagaelkdt qspstcsegl
      721 lgwsqkdlqs efgitgdpqp ssfspsswcq gasqdyglgg asprgdpglg erdwtskygq
      781 gagegstrew asrcgigqee measssqdqs kvsapgvlta qdrvvgkpaq lgtqrsqead
      841 vqdwefrkrd sqgtyssrda elqdqefgkr dslgtyssrd vslgdwefgk rdslgayasq
      901 daneqgqdlg krdhhgryss qdadeqdwef qkrdvslgty gsraaepqeq efgksawird
      961 yssggssrtl daqdrsfgtr plssgfspee aqqqdeefek kipsvedslg egsrdagrpg
     1021 ergsgglfsp stahvpdgal gqrdqsswqn sdasqevggh qerqqagaqg pgsadledge
     1081 mgkrgwvgef slsvgprrea afspgqqdws rdfcieaser syqfgiignd rvsgagfsps
     1141 skmegghfvp pgkttagsvd wtdqlglrnl evsscvgsgg ssearesavg qmgwsgglsl
     1201 rdmnltgcle sggseepggi gvgekdwtsd vnvkskdlae vgeggghsqa resgvgqtdw
     1261 sgveageflk srergvgqad wtpdlglrnm apgavcspge skelgvgqmd wgnnlglrdl
     1321 evtcdpdsgg sqglrgcgvg qmdwtqdlap qnvelfgaps earehgvggv sqcpepglrh
     1381 ngslspglea rdplearelg vgetsgpetq gedyssssle phpadpgmet gealsfgasd
     1441 svqleepelf pgegahprsq gfeparlaql ftcvlccsrp
//
LOCUS       XP_054226302            1053 aa            linear   PRI 05-AUG-2025
DEFINITION  182 kDa tankyrase-1-binding protein isoform X3 [Homo sapiens].
ACCESSION   XP_054226302
VERSION     XP_054226302.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370327.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1053
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1053
                     /product="182 kDa tankyrase-1-binding protein isoform X3"
                     /calculated_mol_wt=111387
     Region          880..1045
                     /region_name="Tankyrase_bdg_C"
                     /note="Tankyrase binding protein C terminal domain;
                     pfam15327"
                     /db_xref="CDD:464648"
     CDS             1..1053
                     /gene="TNKS1BP1"
                     /gene_synonym="CNOT12; TAB182"
                     /coded_by="XM_054370327.1:230..3391"
                     /db_xref="GeneID:85456"
                     /db_xref="HGNC:HGNC:19081"
                     /db_xref="MIM:607104"
ORIGIN      
        1 maqpgdgeas msilerllan aalrdeagrl rspepralpp trgllgwsqk dlqsefgitg
       61 dpqpssfsps swcqgasqdy glggasprgd pglgerdwts kygqgagegs trewasrcgi
      121 gqeemeasss qdqskvsapg vltaqdrvvg kpaqlgtqrs qeadvqdwef rkrdsqgtys
      181 srdaelqdqe fgkrdslgty ssrdvslgdw efgkrdslga yasqdaneqg qdlgkrdhhg
      241 ryssqdadeq dwefqkrdvs lgtygsraae pqeqefgksa wirdyssggs srtldaqdrs
      301 fgtrplssgf speeaqqqde efekkipsve dslgegsrda grpgergsgg lfspstahvp
      361 dgalgqrdqs swqnsdasqe vgghqerqqa gaqgpgsadl edgemgkrgw vgefslsvgp
      421 rreaafspgq qdwsrdfcie asersyqfgi igndrvsgag fspsskmegg hfvppgktta
      481 gsvdwtdqlg lrnlevsscv gsggsseare savgqmgwsg glslrdmnlt gclesggsee
      541 pggigvgekd wtsdvnvksk dlaevgeggg hsqaresgvg qtdwsgveag eflksrergv
      601 gqadwtpdlg lrnmapgavc spgeskelgv gqmdwgnnlg lrdlevtcdp dsggsqglrg
      661 cgvgqmdwtq dlapqnvelf gapsearehg vggvsqcpep glrhngslsp gleardplea
      721 relgvgetsg petqgedyss sslephpadp gmetgealsf gaspgrcpar pppsgsqgll
      781 eemlaasssk avarresaas glgglleeeg agagaaqeev lepgrdspps wrpqpdgeas
      841 qtedvdgtwg ssaarwsdqg paqtsrrpsq gpparspsqd fsfiedteil dsamyrsran
      901 lgrkrghrap virpggtlgl seaadsdarl fqdstepras rvpssdeeva eepqsrrtrm
      961 slgtkglkvn lfpglspsal kaklrprnrs aeegelaesk ssqkesavqr sksckvpglg
     1021 kpltlppkpe kssgsegssp nwlqalklkk kkv
//
LOCUS       XP_054226303             682 aa            linear   PRI 05-AUG-2025
DEFINITION  dixin isoform X1 [Homo sapiens].
ACCESSION   XP_054226303
VERSION     XP_054226303.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370328.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..682
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..682
                     /product="dixin isoform X1"
                     /calculated_mol_wt=77232
     Region          21..127
                     /region_name="CH_DIXDC1"
                     /note="calponin homology (CH) domain found in Dixin and
                     similar proteins; cd21213"
                     /db_xref="CDD:409062"
     Site            order(21,25,79,81..82,85..86,88,97..105,110,112..113,
                     115..116,119..120,123)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409062"
     Region          <280..>479
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          600..675
                     /region_name="DIX"
                     /note="DIX domain; pfam00778"
                     /db_xref="CDD:459936"
     CDS             1..682
                     /gene="DIXDC1"
                     /gene_synonym="CCD1"
                     /coded_by="XM_054370328.1:110..2158"
                     /db_xref="GeneID:85458"
                     /db_xref="HGNC:HGNC:23695"
                     /db_xref="MIM:610493"
ORIGIN      
        1 mgtqvvmrfn nsllptepsq qlqayvawvn aqlkkrpavk pvqdlrqdlr dgvilaylie
       61 ivageklsgv qlspgnqqem knnvekvlqf vaskkirmhq tsakdivdgn lksimrlvla
      121 laahfkpgss rtvnqgrdsr aplqshrphc atavaqgaaa aladvchdms rsgrdvfryr
      181 qrnssmdeei enpywsvral vqqyegqqrs psesscsslt spspihsaks esiitqseek
      241 adfviipaeg ienrtegtds plsrdwrpgs pgtyletswe eqlleqqeyl ekemeeakkm
      301 isglqallln gslpedeqer plalcepgvn peeqliiiqs rldqsmeenq dlkkellkck
      361 qearnlqgik dalqqrltqq dtsvlqlkqe llranmdkde lhnqnvdlqr kldernrllg
      421 eykkelgqkd rllqqhqakl eealrklsdv syhqvdlere lehkdvllah cmkreadeat
      481 nynshnsqsn gfllptagkg atsvsnrgts dlqlvrdalr slrnsfsghd pqhhtidsle
      541 qgisslmerl hvmetqkkqe rkvrvksprt qvgseyresw ppnsklphsq ssptvsstct
      601 kvlyftdrsl tpfmvnipkr leevtlkdfk aaidregnhr yhfkaldpef gtvkeeifhd
      661 ddaipgwegk ivawveedhg en
//
LOCUS       XP_054226304             682 aa            linear   PRI 05-AUG-2025
DEFINITION  dixin isoform X1 [Homo sapiens].
ACCESSION   XP_054226304
VERSION     XP_054226304.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370329.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..682
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..682
                     /product="dixin isoform X1"
                     /calculated_mol_wt=77232
     Region          21..127
                     /region_name="CH_DIXDC1"
                     /note="calponin homology (CH) domain found in Dixin and
                     similar proteins; cd21213"
                     /db_xref="CDD:409062"
     Site            order(21,25,79,81..82,85..86,88,97..105,110,112..113,
                     115..116,119..120,123)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409062"
     Region          <280..>479
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          600..675
                     /region_name="DIX"
                     /note="DIX domain; pfam00778"
                     /db_xref="CDD:459936"
     CDS             1..682
                     /gene="DIXDC1"
                     /gene_synonym="CCD1"
                     /coded_by="XM_054370329.1:86..2134"
                     /db_xref="GeneID:85458"
                     /db_xref="HGNC:HGNC:23695"
                     /db_xref="MIM:610493"
ORIGIN      
        1 mgtqvvmrfn nsllptepsq qlqayvawvn aqlkkrpavk pvqdlrqdlr dgvilaylie
       61 ivageklsgv qlspgnqqem knnvekvlqf vaskkirmhq tsakdivdgn lksimrlvla
      121 laahfkpgss rtvnqgrdsr aplqshrphc atavaqgaaa aladvchdms rsgrdvfryr
      181 qrnssmdeei enpywsvral vqqyegqqrs psesscsslt spspihsaks esiitqseek
      241 adfviipaeg ienrtegtds plsrdwrpgs pgtyletswe eqlleqqeyl ekemeeakkm
      301 isglqallln gslpedeqer plalcepgvn peeqliiiqs rldqsmeenq dlkkellkck
      361 qearnlqgik dalqqrltqq dtsvlqlkqe llranmdkde lhnqnvdlqr kldernrllg
      421 eykkelgqkd rllqqhqakl eealrklsdv syhqvdlere lehkdvllah cmkreadeat
      481 nynshnsqsn gfllptagkg atsvsnrgts dlqlvrdalr slrnsfsghd pqhhtidsle
      541 qgisslmerl hvmetqkkqe rkvrvksprt qvgseyresw ppnsklphsq ssptvsstct
      601 kvlyftdrsl tpfmvnipkr leevtlkdfk aaidregnhr yhfkaldpef gtvkeeifhd
      661 ddaipgwegk ivawveedhg en
//
LOCUS       XP_054226305             647 aa            linear   PRI 05-AUG-2025
DEFINITION  dixin isoform X2 [Homo sapiens].
ACCESSION   XP_054226305
VERSION     XP_054226305.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370330.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..647
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..647
                     /product="dixin isoform X2"
                     /calculated_mol_wt=73187
     Region          22..128
                     /region_name="CH_DIXDC1"
                     /note="calponin homology (CH) domain found in Dixin and
                     similar proteins; cd21213"
                     /db_xref="CDD:409062"
     Site            order(22,26,80,82..83,86..87,89,98..106,111,113..114,
                     116..117,120..121,124)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409062"
     Region          <245..>444
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          565..640
                     /region_name="DIX"
                     /note="DIX domain; pfam00778"
                     /db_xref="CDD:459936"
     CDS             1..647
                     /gene="DIXDC1"
                     /gene_synonym="CCD1"
                     /coded_by="XM_054370330.1:158..2101"
                     /db_xref="GeneID:85458"
                     /db_xref="HGNC:HGNC:23695"
                     /db_xref="MIM:610493"
ORIGIN      
        1 mlacltrgnl ldvlqegfne qqlqayvawv naqlkkrpav kpvqdlrqdl rdgvilayli
       61 eivageklsg vqlspgnqqe mknnvekvlq fvaskkirmh qtsakdivdg nlksimrlvl
      121 alaahfkpgs srtvnqgrds raplqshrph catavaqgaa aaladvchdm srsgrdvfry
      181 rqsltspspi hsaksesiit qseekadfvi ipaegienrt egtdsplsrd wrpgspgtyl
      241 etsweeqlle qqeylekeme eakkmisglq alllngslpe deqerplalc epgvnpeeql
      301 iiiqsrldqs meenqdlkke llkckqearn lqgikdalqq rltqqdtsvl qlkqellran
      361 mdkdelhnqn vdlqrklder nrllgeykke lgqkdrllqq hqakleealr klsdvsyhqv
      421 dlerelehkd vllahcmkre adeatnynsh nsqsngfllp tagkgatsvs nrgtsdlqlv
      481 rdalrslrns fsghdpqhht idsleqgiss lmerlhvmet qkkqerkvrv ksprtqvgse
      541 yreswppnsk lphsqssptv sstctkvlyf tdrsltpfmv nipkrleevt lkdfkaaidr
      601 egnhryhfka ldpefgtvke eifhdddaip gwegkivawv eedhgen
//
LOCUS       XP_054226306             646 aa            linear   PRI 05-AUG-2025
DEFINITION  dixin isoform X3 [Homo sapiens].
ACCESSION   XP_054226306
VERSION     XP_054226306.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370331.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..646
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..646
                     /product="dixin isoform X3"
                     /calculated_mol_wt=73072
     Region          21..127
                     /region_name="CH_DIXDC1"
                     /note="calponin homology (CH) domain found in Dixin and
                     similar proteins; cd21213"
                     /db_xref="CDD:409062"
     Site            order(21,25,79,81..82,85..86,88,97..105,110,112..113,
                     115..116,119..120,123)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409062"
     Region          <244..>443
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          564..639
                     /region_name="DIX"
                     /note="DIX domain; pfam00778"
                     /db_xref="CDD:459936"
     CDS             1..646
                     /gene="DIXDC1"
                     /gene_synonym="CCD1"
                     /coded_by="XM_054370331.1:110..2050"
                     /db_xref="GeneID:85458"
                     /db_xref="HGNC:HGNC:23695"
                     /db_xref="MIM:610493"
ORIGIN      
        1 mgtqvvmrfn nsllptepsq qlqayvawvn aqlkkrpavk pvqdlrqdlr dgvilaylie
       61 ivageklsgv qlspgnqqem knnvekvlqf vaskkirmhq tsakdivdgn lksimrlvla
      121 laahfkpgss rtvnqgrdsr aplqshrphc atavaqgaaa aladvchdms rsgrdvfryr
      181 qsltspspih saksesiitq seekadfvii paegienrte gtdsplsrdw rpgspgtyle
      241 tsweeqlleq qeylekemee akkmisglqa lllngslped eqerplalce pgvnpeeqli
      301 iiqsrldqsm eenqdlkkel lkckqearnl qgikdalqqr ltqqdtsvlq lkqellranm
      361 dkdelhnqnv dlqrkldern rllgeykkel gqkdrllqqh qakleealrk lsdvsyhqvd
      421 lerelehkdv llahcmkrea deatnynshn sqsngfllpt agkgatsvsn rgtsdlqlvr
      481 dalrslrnsf sghdpqhhti dsleqgissl merlhvmetq kkqerkvrvk sprtqvgsey
      541 reswppnskl phsqssptvs stctkvlyft drsltpfmvn ipkrleevtl kdfkaaidre
      601 gnhryhfkal dpefgtvkee ifhdddaipg wegkivawve edhgen
//
LOCUS       XP_054226307             387 aa            linear   PRI 05-AUG-2025
DEFINITION  dixin isoform X4 [Homo sapiens].
ACCESSION   XP_054226307
VERSION     XP_054226307.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370332.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..387
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..387
                     /product="dixin isoform X4"
                     /calculated_mol_wt=44302
     Region          <37..>193
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          305..380
                     /region_name="DIX"
                     /note="DIX domain; pfam00778"
                     /db_xref="CDD:459936"
     CDS             1..387
                     /gene="DIXDC1"
                     /gene_synonym="CCD1"
                     /coded_by="XM_054370332.1:139..1302"
                     /db_xref="GeneID:85458"
                     /db_xref="HGNC:HGNC:23695"
                     /db_xref="MIM:610493"
ORIGIN      
        1 mdltkgtspr alllngslpe deqerplalc epgvnpeeql iiiqsrldqs meenqdlkke
       61 llkckqearn lqgikdalqq rltqqdtsvl qlkqellran mdkdelhnqn vdlqrklder
      121 nrllgeykke lgqkdrllqq hqakleealr klsdvsyhqv dlerelehkd vllahcmkre
      181 adeatnynsh nsqsngfllp tagkgatsvs nrgtsdlqlv rdalrslrns fsghdpqhht
      241 idsleqgiss lmerlhvmet qkkqerkvrv ksprtqvgse yreswppnsk lphsqssptv
      301 sstctkvlyf tdrsltpfmv nipkrleevt lkdfkaaidr egnhryhfka ldpefgtvke
      361 eifhdddaip gwegkivawv eedhgen
//
LOCUS       XP_054226308            2645 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 295 kDa isoform X1 [Homo sapiens].
ACCESSION   XP_054226308
VERSION     XP_054226308.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370333.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2645
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2645
                     /product="centrosomal protein of 295 kDa isoform X1"
                     /calculated_mol_wt=300057
     Region          <27..554
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          2492..2603
                     /region_name="ALMS_motif"
                     /note="ALMS motif; pfam15309"
                     /db_xref="CDD:464634"
     CDS             1..2645
                     /gene="CEP295"
                     /gene_synonym="KIAA1731; SCKL11"
                     /coded_by="XM_054370333.1:120..8057"
                     /db_xref="GeneID:85459"
                     /db_xref="HGNC:HGNC:29366"
                     /db_xref="MIM:617728"
ORIGIN      
        1 mkrkvvnthk lrlspneeaf ilkedyerrr klrllqvreq erdialqire dikqrrnqqf
       61 trlaeelrae weesqtqkiq nleklylasl rsmgeghrqa kenepdldal aqraaerkrk
      121 adlrhkealk vqknqkeill kqktwhikar keallveker sakitslppp pptlfeniev
      181 krisavktns styhhlhtfv nretdtkqpd arlaaeeeak rleelqkqaa qermerfeka
      241 hvrgfqamkk ihlaqnqekl mkelkqlqqe dlarrrqtva qmppqlvelp ykrsemkedw
      301 qrelefafed mynadrkvkg nlilhlepep lptvtnqiqd eeldlsmeqe nlgaaedlpv
      361 teaeicsset dvplvmktqq ipskvlfkkl lnkirsqksl wtiksmsede semittvsei
      421 eskaptvesg tiaskertls sgqeqvvesd tltiesgpla sedkplscgt nsgkeqeine
      481 tlpittvaqs svllhpqeea arirmsarqk qimeieeqkq kqlelleqie qqklrletdc
      541 fraqleeekr kktqptgvgc rkshhyinhl vgiapascpv isdedshrqm irnyqhqllq
      601 qnrlhrqsve tarkqlleyq tmlkgrcpsv sapslitdsv isvpswkser ptaisehwdq
      661 gqrlklspnk yqpiqpiqts kleqdhfqva rqnhfpqrqv ettetlrasd iltnqalesq
      721 ehlrqfsqte tqqrdyklvp kdsetlsral shdrqlisqd arkisetfga ttfqslesqq
      781 lfsensenis yhltepssfv plvpqhsfss lpvkvesgki qepfsamsks tvstshsiis
      841 qmhdrpllps enitaqqgnm kalqeqldlq kkvlqatqea qeqlllckqk eveqqtglsv
      901 flplvtpdss allpsakadl griqessptk nniavssdhh visqlqdkrl slsqpilsqq
      961 nnfkflqeql niqkdslqar reaqevlyvh kqseldrrvc seqaepsfpf qvaqhtftsl
     1021 psadtksgki qeqhssksek glvscqsdip isqdgslsfl qqflplhdsl kllqeqltkq
     1081 rdtlqarhea qvelllhrqr dlgdsksglv ssssspvvvq hsvasqasak aeprriqely
     1141 lsekenvgps chliiptfqd kslsfpqhsl aqqenltilq eqsqiqrvil gakegtqefv
     1201 hteselekri sseqtgtsss lsqvdeserf qecisiksds tiplshpkip rcqerllrvs
     1261 qhmlplqdnl eehqawldte keafhfsqkt qentsseqtg sssfipqlvq lsftslasae
     1321 sgtileplft eseskifssh lqipqlqdrl lrisqliqpq qdnlkalqeq latqreaiil
     1381 arqeareell lhqsewegri speqvdtssl plvpqhsfas lplnesernq epcsinsdni
     1441 vssghseipt lpdgllglsh lvlpqqdnli aleehlhaqt dflpsiektq kelvlskpck
     1501 feekvssehf iqshhgdlqa lqqqldtqkk airsiqevqe elllqrlsel ekrvsseqvc
     1561 sssfvsqvpv adsertqksf ptksndtlps shreiprlqd rllslskpil pqqdnmtaql
     1621 daqrevmysy ekpqeelsln kqrklnkses aehtipslfl pketehsfip lpfaeakpks
     1681 tcelyssqne haappsnpvi pgfqdrllsf sqsvltqqdn lglqkqldlq revlhysqka
     1741 qekllvqrqt alqqqiqkhe etlkdffkds qiskptvend lktqkmgqlr dwfpntqdla
     1801 gndqenirha drnnsddnhl asedtsakqs gehlekdlgr rsskppvakv kcgldlnqhe
     1861 lsaiqevesp aigrtsilgk pgiyedrdpl rvsisreqsf fgsplahdpf sclqlvgqen
     1921 vcgddydeav klkesvvenh avlsyaveee haylgptvkp ddkaktlsye plssatvstg
     1981 sllsyentdl sltdpesfse hmddskqest tskeeetnii ssivpstqdi yqrqnssdvh
     2041 ksllpavdet tcghthfqqm idkyineanl ipektdlqel ehifpnlhhq lfkplephpd
     2101 fdlsssssgi spdnrdfyqr sdssseshca tglskstvyf talrrtsmhs slntspnqqp
     2161 dtnlahvgah sfateniigg seqcfeqlqp eyssqeesqh adlpsifsie ardssqgmkn
     2221 qnypseehte ilqnkkkivh fqlsignlss vysssdeanv fdqlnvqhst pcgsnssecs
     2281 tkhqlesrke smgfeelskr gvvtmlqsqg liednknetc rvldinpqve etdsrlcvrt
     2341 vemgtsiqap yslttqneky fensaetdip kitkklsqlg eselfassgs fslqssipvw
     2401 etetghgime epeltlistt dtsiaemdfa nltleeksen eakcffqvsv flplvsatea
     2461 sdypavsels iekprtasta etprrltpvp gslqeafikr kksfmershq rqkeirnkih
     2521 vsensqiktv kekpsisssv srlkgvnkvr asfpedrktt qalrhqrglr lynqlaevkq
     2581 qkeektkqea yaqnrarake fhkvsitege glnfssmkyt tetqifipst entretssqk
     2641 ymltf
//
LOCUS       XP_054226309            2644 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 295 kDa isoform X2 [Homo sapiens].
ACCESSION   XP_054226309
VERSION     XP_054226309.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370334.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2644
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2644
                     /product="centrosomal protein of 295 kDa isoform X2"
                     /calculated_mol_wt=299986
     Region          <27..554
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          2491..2602
                     /region_name="ALMS_motif"
                     /note="ALMS motif; pfam15309"
                     /db_xref="CDD:464634"
     CDS             1..2644
                     /gene="CEP295"
                     /gene_synonym="KIAA1731; SCKL11"
                     /coded_by="XM_054370334.1:120..8054"
                     /db_xref="GeneID:85459"
                     /db_xref="HGNC:HGNC:29366"
                     /db_xref="MIM:617728"
ORIGIN      
        1 mkrkvvnthk lrlspneeaf ilkedyerrr klrllqvreq erdialqire dikqrrnqqf
       61 trlaeelrae weesqtqkiq nleklylasl rsmgeghrqa kenepdldal aqraaerkrk
      121 adlrhkealk vqknqkeill kqktwhikar keallveker sakitslppp pptlfeniev
      181 krisavktns styhhlhtfv nretdtkqpd arlaaeeeak rleelqkqaa qermerfeka
      241 hvrgfqamkk ihlaqnqekl mkelkqlqqe dlarrrqtva qmppqlvelp ykrsemkedw
      301 qrelefafed mynadrkvkg nlilhlepep lptvtnqiqd eeldlsmeqe nlgaaedlpv
      361 teaeicsset dvplvmktqq ipskvlfkkl lnkirsqksl wtiksmsede semittvsei
      421 eskaptvesg tiaskertls sgqeqvvesd tltiesgpla sedkplscgt nsgkeqeine
      481 tlpittvaqs svllhpqeea arirmsarqk qimeieeqkq kqlelleqie qqklrletdc
      541 fraqleeekr kktqptgvgc rkshhyinhl vgiapascpv isdedshrqm irnyqhqllq
      601 qnrlhrqsve tarkqlleyq tmlkgrcpsv sapslitdsv isvpswkser ptaisehwdq
      661 gqrlklspnk yqpiqpiqts kleqdhfqva rqnhfpqrqv ettetlrasd iltnqalesq
      721 ehlrqfsqte tqqrdyklvp kdsetlsral shdrqlisqd arkisetfga ttfqslesqq
      781 lfsensenis yhltepssfv plvpqhsfss lpvkvesgki qepfsamsks tvstshsiis
      841 qmhdrpllps enitaqqgnm kalqeqldlq kkvlqatqea qeqlllckqk eveqqtglsv
      901 flplvtpdss allpsakadl griqessptk nniavssdhh visqlqdkrl slsqpilsqq
      961 nnfkflqeql niqkdslqar reaqevlyvh kqseldrrvc seqaepsfpf qvaqhtftsl
     1021 psadtksgki qeqhssksek glvscqsdip isqdgslsfl qqflplhdsl kllqeqltkq
     1081 rdtlqarhea qvelllhrqr dlgdsksglv ssssspvvvq hsvasqasak aeprriqely
     1141 lsekenvgps chliiptfqd kslsfpqhsl aqqenltilq eqsqiqrvil gakegtqefv
     1201 hteselekri sseqtgtsss lsqvdeserf qecisiksds tiplshpkip rcqerllrvs
     1261 qhmlplqdnl eehqawldte keafhfsqkt qentsseqtg sssfipqlvq lsftslasae
     1321 sgtileplft eseskifssh lqipqlqdrl lrisqliqpq qdnlkalqeq latqreaiil
     1381 arqeareell lhqsewegri speqvdtssl plvpqhsfas lplnesernq epcsinsdni
     1441 vssghseipt lpdgllglsh lvlpqqdnli aleehlhaqt dflpsiektq kelvlskpck
     1501 feekvssehf iqshhgdlqa lqqqldtqkk airsiqevqe elllqrlsel ekrvsseqvc
     1561 sssfvsqvpv adsertqksf ptksndtlps shreiprlqd rllslskpil pqqdnmtaql
     1621 daqrevmysy ekpqeelsln kqrklnkses aehtipslfl pketehsfip lpfaeakpks
     1681 tcelyssqne haappsnpvi pgfqdrllsf sqsvltqqdn lglqkqldlq revlhysqka
     1741 qekllvqrqt alqqqiqkhe etlkdffkds qiskptvend lktqkmgqlr dwfpntqdla
     1801 gndqenirha drnnsddnhl asedtsakqs gehlekdlgr rsskppvakv kcgldlnqhe
     1861 lsaiqevesp aigrtsilgk pgiyedrdpl rvsisreqsf fgsplahdpf sclqlvgqen
     1921 vcgddydeav klkesvvenh avlsyaveee haylgptvkp ddkaktlsye plssatvstg
     1981 sllsyentdl sltdpesfse hmddskqest tskeeetnii ssivpstqdi yqrqnssdvh
     2041 ksllpavdet tcghthfqqm idkyineanl ipektdlqel ehifpnlhhq lfkplephpd
     2101 fdlsssssgi spdnrdfyqr sdssseshca tglskstvyf talrrtsmhs slntspnqqp
     2161 dtnlahvgah sfateniigg seqcfeqlqp eyssqeesqh adlpsifsie ardssqgmkn
     2221 qnypseehte ilqnkkkivh fqlsignlss vysssdeanv fdqlnvqhst pcgsnssecs
     2281 tkhqlesrke smgfeelskr gvvtmlqsqg liednknetc rvldinpqve etdsrlcvrt
     2341 vemgtsiqap yslttqneky fensaetdip kitkklsqlg eselfassgs fslqssipvw
     2401 etetghgime epeltlistt dtsiaemdfa nltleeksen eakcffqvsv flplvsatea
     2461 sdypavsels iekprtaste tprrltpvpg slqeafikrk ksfmershqr qkeirnkihv
     2521 sensqiktvk ekpsisssvs rlkgvnkvra sfpedrkttq alrhqrglrl ynqlaevkqq
     2581 keektkqeay aqnrarakef hkvsitegeg lnfssmkytt etqifipste ntretssqky
     2641 mltf
//
LOCUS       XP_054226310            2632 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 295 kDa isoform X3 [Homo sapiens].
ACCESSION   XP_054226310
VERSION     XP_054226310.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370335.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2632
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2632
                     /product="centrosomal protein of 295 kDa isoform X3"
                     /calculated_mol_wt=298511
     Region          <27..554
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          2479..2590
                     /region_name="ALMS_motif"
                     /note="ALMS motif; pfam15309"
                     /db_xref="CDD:464634"
     CDS             1..2632
                     /gene="CEP295"
                     /gene_synonym="KIAA1731; SCKL11"
                     /coded_by="XM_054370335.1:120..8018"
                     /db_xref="GeneID:85459"
                     /db_xref="HGNC:HGNC:29366"
                     /db_xref="MIM:617728"
ORIGIN      
        1 mkrkvvnthk lrlspneeaf ilkedyerrr klrllqvreq erdialqire dikqrrnqqf
       61 trlaeelrae weesqtqkiq nleklylasl rsmgeghrqa kenepdldal aqraaerkrk
      121 adlrhkealk vqknqkeill kqktwhikar keallveker sakitslppp pptlfeniev
      181 krisavktns styhhlhtfv nretdtkqpd arlaaeeeak rleelqkqaa qermerfeka
      241 hvrgfqamkk ihlaqnqekl mkelkqlqqe dlarrrqtva qmppqlvelp ykrsemkedw
      301 qrelefafed mynadrkvkg nlilhlepep lptvtnqiqd eeldlsmeqe nlgaaedlpv
      361 teaeicsset dvplvmktqq ipskvlfkkl lnkirsqksl wtiksmsede semittvsei
      421 eskaptvesg tiaskertls sgqeqvvesd tltiesgpla sedkplscgt nsgkeqeine
      481 tlpittvaqs svllhpqeea arirmsarqk qimeieeqkq kqlelleqie qqklrletdc
      541 fraqleeekr kktqptgvgi apascpvisd edshrqmirn yqhqllqqnr lhrqsvetar
      601 kqlleyqtml kgrcpsvsap slitdsvisv pswkserpta isehwdqgqr lklspnkyqp
      661 iqpiqtskle qdhfqvarqn hfpqrqvett etlrasdilt nqalesqehl rqfsqtetqq
      721 rdyklvpkds etlsralshd rqlisqdark isetfgattf qslesqqlfs ensenisyhl
      781 tepssfvplv pqhsfsslpv kvesgkiqep fsamskstvs tshsiisqmh drpllpseni
      841 taqqgnmkal qeqldlqkkv lqatqeaqeq lllckqkeve qqtglsvflp lvtpdssall
      901 psakadlgri qessptknni avssdhhvis qlqdkrlsls qpilsqqnnf kflqeqlniq
      961 kdslqarrea qevlyvhkqs eldrrvcseq aepsfpfqva qhtftslpsa dtksgkiqeq
     1021 hssksekglv scqsdipisq dgslsflqqf lplhdslkll qeqltkqrdt lqarheaqve
     1081 lllhrqrdlg dsksglvsss sspvvvqhsv asqasakaep rriqelylse kenvgpschl
     1141 iiptfqdksl sfpqhslaqq enltilqeqs qiqrvilgak egtqefvhte selekrisse
     1201 qtgtssslsq vdeserfqec isiksdstip lshpkiprcq erllrvsqhm lplqdnleeh
     1261 qawldtekea fhfsqktqen tsseqtgsss fipqlvqlsf tslasaesgt ileplftese
     1321 skifsshlqi pqlqdrllri sqliqpqqdn lkalqeqlat qreaiilarq eareelllhq
     1381 sewegrispe qvdtsslplv pqhsfaslpl nesernqepc sinsdnivss ghseiptlpd
     1441 gllglshlvl pqqdnliale ehlhaqtdfl psiektqkel vlskpckfee kvssehfiqs
     1501 hhgdlqalqq qldtqkkair siqevqeell lqrlselekr vsseqvcsss fvsqvpvads
     1561 ertqksfptk sndtlpsshr eiprlqdrll slskpilpqq dnmtaqldaq revmysyekp
     1621 qeelslnkqr klnksesaeh tipslflpke tehsfiplpf aeakpkstce lyssqnehaa
     1681 ppsnpvipgf qdrllsfsqs vltqqdnlgl qkqldlqrev lhysqkaqek llvqrqtalq
     1741 qqiqkheetl kdffkdsqis kptvendlkt qkmgqlrdwf pntqdlagnd qenirhadrn
     1801 nsddnhlase dtsakqsgeh lekdlgrrss kppvakvkcg ldlnqhelsa iqevespaig
     1861 rtsilgkpgi yedrdplrvs isreqsffgs plahdpfscl qlvgqenvcg ddydeavklk
     1921 esvvenhavl syaveeehay lgptvkpddk aktlsyepls satvstgsll syentdlslt
     1981 dpesfsehmd dskqesttsk eeetniissi vpstqdiyqr qnssdvhksl lpavdettcg
     2041 hthfqqmidk yineanlipe ktdlqelehi fpnlhhqlfk plephpdfdl sssssgispd
     2101 nrdfyqrsds sseshcatgl skstvyftal rrtsmhssln tspnqqpdtn lahvgahsfa
     2161 teniiggseq cfeqlqpeys sqeesqhadl psifsieard ssqgmknqny pseehteilq
     2221 nkkkivhfql signlssvys ssdeanvfdq lnvqhstpcg snssecstkh qlesrkesmg
     2281 feelskrgvv tmlqsqglie dnknetcrvl dinpqveetd srlcvrtvem gtsiqapysl
     2341 ttqnekyfen saetdipkit kklsqlgese lfassgsfsl qssipvwete tghgimeepe
     2401 ltlisttdts iaemdfanlt leekseneak cffqvsvflp lvsateasdy pavselsiek
     2461 prtastaetp rrltpvpgsl qeafikrkks fmershqrqk eirnkihvse nsqiktvkek
     2521 psisssvsrl kgvnkvrasf pedrkttqal rhqrglrlyn qlaevkqqke ektkqeayaq
     2581 nrarakefhk vsitegegln fssmkyttet qifipstent retssqkyml tf
//
LOCUS       XP_054226311            2631 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 295 kDa isoform X4 [Homo sapiens].
ACCESSION   XP_054226311
VERSION     XP_054226311.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370336.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2631
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2631
                     /product="centrosomal protein of 295 kDa isoform X4"
                     /calculated_mol_wt=298440
     Region          <27..554
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          2478..2589
                     /region_name="ALMS_motif"
                     /note="ALMS motif; pfam15309"
                     /db_xref="CDD:464634"
     CDS             1..2631
                     /gene="CEP295"
                     /gene_synonym="KIAA1731; SCKL11"
                     /coded_by="XM_054370336.1:120..8015"
                     /db_xref="GeneID:85459"
                     /db_xref="HGNC:HGNC:29366"
                     /db_xref="MIM:617728"
ORIGIN      
        1 mkrkvvnthk lrlspneeaf ilkedyerrr klrllqvreq erdialqire dikqrrnqqf
       61 trlaeelrae weesqtqkiq nleklylasl rsmgeghrqa kenepdldal aqraaerkrk
      121 adlrhkealk vqknqkeill kqktwhikar keallveker sakitslppp pptlfeniev
      181 krisavktns styhhlhtfv nretdtkqpd arlaaeeeak rleelqkqaa qermerfeka
      241 hvrgfqamkk ihlaqnqekl mkelkqlqqe dlarrrqtva qmppqlvelp ykrsemkedw
      301 qrelefafed mynadrkvkg nlilhlepep lptvtnqiqd eeldlsmeqe nlgaaedlpv
      361 teaeicsset dvplvmktqq ipskvlfkkl lnkirsqksl wtiksmsede semittvsei
      421 eskaptvesg tiaskertls sgqeqvvesd tltiesgpla sedkplscgt nsgkeqeine
      481 tlpittvaqs svllhpqeea arirmsarqk qimeieeqkq kqlelleqie qqklrletdc
      541 fraqleeekr kktqptgvgi apascpvisd edshrqmirn yqhqllqqnr lhrqsvetar
      601 kqlleyqtml kgrcpsvsap slitdsvisv pswkserpta isehwdqgqr lklspnkyqp
      661 iqpiqtskle qdhfqvarqn hfpqrqvett etlrasdilt nqalesqehl rqfsqtetqq
      721 rdyklvpkds etlsralshd rqlisqdark isetfgattf qslesqqlfs ensenisyhl
      781 tepssfvplv pqhsfsslpv kvesgkiqep fsamskstvs tshsiisqmh drpllpseni
      841 taqqgnmkal qeqldlqkkv lqatqeaqeq lllckqkeve qqtglsvflp lvtpdssall
      901 psakadlgri qessptknni avssdhhvis qlqdkrlsls qpilsqqnnf kflqeqlniq
      961 kdslqarrea qevlyvhkqs eldrrvcseq aepsfpfqva qhtftslpsa dtksgkiqeq
     1021 hssksekglv scqsdipisq dgslsflqqf lplhdslkll qeqltkqrdt lqarheaqve
     1081 lllhrqrdlg dsksglvsss sspvvvqhsv asqasakaep rriqelylse kenvgpschl
     1141 iiptfqdksl sfpqhslaqq enltilqeqs qiqrvilgak egtqefvhte selekrisse
     1201 qtgtssslsq vdeserfqec isiksdstip lshpkiprcq erllrvsqhm lplqdnleeh
     1261 qawldtekea fhfsqktqen tsseqtgsss fipqlvqlsf tslasaesgt ileplftese
     1321 skifsshlqi pqlqdrllri sqliqpqqdn lkalqeqlat qreaiilarq eareelllhq
     1381 sewegrispe qvdtsslplv pqhsfaslpl nesernqepc sinsdnivss ghseiptlpd
     1441 gllglshlvl pqqdnliale ehlhaqtdfl psiektqkel vlskpckfee kvssehfiqs
     1501 hhgdlqalqq qldtqkkair siqevqeell lqrlselekr vsseqvcsss fvsqvpvads
     1561 ertqksfptk sndtlpsshr eiprlqdrll slskpilpqq dnmtaqldaq revmysyekp
     1621 qeelslnkqr klnksesaeh tipslflpke tehsfiplpf aeakpkstce lyssqnehaa
     1681 ppsnpvipgf qdrllsfsqs vltqqdnlgl qkqldlqrev lhysqkaqek llvqrqtalq
     1741 qqiqkheetl kdffkdsqis kptvendlkt qkmgqlrdwf pntqdlagnd qenirhadrn
     1801 nsddnhlase dtsakqsgeh lekdlgrrss kppvakvkcg ldlnqhelsa iqevespaig
     1861 rtsilgkpgi yedrdplrvs isreqsffgs plahdpfscl qlvgqenvcg ddydeavklk
     1921 esvvenhavl syaveeehay lgptvkpddk aktlsyepls satvstgsll syentdlslt
     1981 dpesfsehmd dskqesttsk eeetniissi vpstqdiyqr qnssdvhksl lpavdettcg
     2041 hthfqqmidk yineanlipe ktdlqelehi fpnlhhqlfk plephpdfdl sssssgispd
     2101 nrdfyqrsds sseshcatgl skstvyftal rrtsmhssln tspnqqpdtn lahvgahsfa
     2161 teniiggseq cfeqlqpeys sqeesqhadl psifsieard ssqgmknqny pseehteilq
     2221 nkkkivhfql signlssvys ssdeanvfdq lnvqhstpcg snssecstkh qlesrkesmg
     2281 feelskrgvv tmlqsqglie dnknetcrvl dinpqveetd srlcvrtvem gtsiqapysl
     2341 ttqnekyfen saetdipkit kklsqlgese lfassgsfsl qssipvwete tghgimeepe
     2401 ltlisttdts iaemdfanlt leekseneak cffqvsvflp lvsateasdy pavselsiek
     2461 prtastetpr rltpvpgslq eafikrkksf mershqrqke irnkihvsen sqiktvkekp
     2521 sisssvsrlk gvnkvrasfp edrkttqalr hqrglrlynq laevkqqkee ktkqeayaqn
     2581 rarakefhkv sitegeglnf ssmkyttetq ifipstentr etssqkymlt f
//
LOCUS       XP_054226312            2615 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 295 kDa isoform X5 [Homo sapiens].
ACCESSION   XP_054226312
VERSION     XP_054226312.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370337.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2615
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2615
                     /product="centrosomal protein of 295 kDa isoform X5"
                     /calculated_mol_wt=296663
     Region          <27..554
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          2492..2613
                     /region_name="ALMS_motif"
                     /note="ALMS motif; pfam15309"
                     /db_xref="CDD:464634"
     CDS             1..2615
                     /gene="CEP295"
                     /gene_synonym="KIAA1731; SCKL11"
                     /coded_by="XM_054370337.1:120..7967"
                     /db_xref="GeneID:85459"
                     /db_xref="HGNC:HGNC:29366"
                     /db_xref="MIM:617728"
ORIGIN      
        1 mkrkvvnthk lrlspneeaf ilkedyerrr klrllqvreq erdialqire dikqrrnqqf
       61 trlaeelrae weesqtqkiq nleklylasl rsmgeghrqa kenepdldal aqraaerkrk
      121 adlrhkealk vqknqkeill kqktwhikar keallveker sakitslppp pptlfeniev
      181 krisavktns styhhlhtfv nretdtkqpd arlaaeeeak rleelqkqaa qermerfeka
      241 hvrgfqamkk ihlaqnqekl mkelkqlqqe dlarrrqtva qmppqlvelp ykrsemkedw
      301 qrelefafed mynadrkvkg nlilhlepep lptvtnqiqd eeldlsmeqe nlgaaedlpv
      361 teaeicsset dvplvmktqq ipskvlfkkl lnkirsqksl wtiksmsede semittvsei
      421 eskaptvesg tiaskertls sgqeqvvesd tltiesgpla sedkplscgt nsgkeqeine
      481 tlpittvaqs svllhpqeea arirmsarqk qimeieeqkq kqlelleqie qqklrletdc
      541 fraqleeekr kktqptgvgc rkshhyinhl vgiapascpv isdedshrqm irnyqhqllq
      601 qnrlhrqsve tarkqlleyq tmlkgrcpsv sapslitdsv isvpswkser ptaisehwdq
      661 gqrlklspnk yqpiqpiqts kleqdhfqva rqnhfpqrqv ettetlrasd iltnqalesq
      721 ehlrqfsqte tqqrdyklvp kdsetlsral shdrqlisqd arkisetfga ttfqslesqq
      781 lfsensenis yhltepssfv plvpqhsfss lpvkvesgki qepfsamsks tvstshsiis
      841 qmhdrpllps enitaqqgnm kalqeqldlq kkvlqatqea qeqlllckqk eveqqtglsv
      901 flplvtpdss allpsakadl griqessptk nniavssdhh visqlqdkrl slsqpilsqq
      961 nnfkflqeql niqkdslqar reaqevlyvh kqseldrrvc seqaepsfpf qvaqhtftsl
     1021 psadtksgki qeqhssksek glvscqsdip isqdgslsfl qqflplhdsl kllqeqltkq
     1081 rdtlqarhea qvelllhrqr dlgdsksglv ssssspvvvq hsvasqasak aeprriqely
     1141 lsekenvgps chliiptfqd kslsfpqhsl aqqenltilq eqsqiqrvil gakegtqefv
     1201 hteselekri sseqtgtsss lsqvdeserf qecisiksds tiplshpkip rcqerllrvs
     1261 qhmlplqdnl eehqawldte keafhfsqkt qentsseqtg sssfipqlvq lsftslasae
     1321 sgtileplft eseskifssh lqipqlqdrl lrisqliqpq qdnlkalqeq latqreaiil
     1381 arqeareell lhqsewegri speqvdtssl plvpqhsfas lplnesernq epcsinsdni
     1441 vssghseipt lpdgllglsh lvlpqqdnli aleehlhaqt dflpsiektq kelvlskpck
     1501 feekvssehf iqshhgdlqa lqqqldtqkk airsiqevqe elllqrlsel ekrvsseqvc
     1561 sssfvsqvpv adsertqksf ptksndtlps shreiprlqd rllslskpil pqqdnmtaql
     1621 daqrevmysy ekpqeelsln kqrklnkses aehtipslfl pketehsfip lpfaeakpks
     1681 tcelyssqne haappsnpvi pgfqdrllsf sqsvltqqdn lglqkqldlq revlhysqka
     1741 qekllvqrqt alqqqiqkhe etlkdffkds qiskptvend lktqkmgqlr dwfpntqdla
     1801 gndqenirha drnnsddnhl asedtsakqs gehlekdlgr rsskppvakv kcgldlnqhe
     1861 lsaiqevesp aigrtsilgk pgiyedrdpl rvsisreqsf fgsplahdpf sclqlvgqen
     1921 vcgddydeav klkesvvenh avlsyaveee haylgptvkp ddkaktlsye plssatvstg
     1981 sllsyentdl sltdpesfse hmddskqest tskeeetnii ssivpstqdi yqrqnssdvh
     2041 ksllpavdet tcghthfqqm idkyineanl ipektdlqel ehifpnlhhq lfkplephpd
     2101 fdlsssssgi spdnrdfyqr sdssseshca tglskstvyf talrrtsmhs slntspnqqp
     2161 dtnlahvgah sfateniigg seqcfeqlqp eyssqeesqh adlpsifsie ardssqgmkn
     2221 qnypseehte ilqnkkkivh fqlsignlss vysssdeanv fdqlnvqhst pcgsnssecs
     2281 tkhqlesrke smgfeelskr gvvtmlqsqg liednknetc rvldinpqve etdsrlcvrt
     2341 vemgtsiqap yslttqneky fensaetdip kitkklsqlg eselfassgs fslqssipvw
     2401 etetghgime epeltlistt dtsiaemdfa nltleeksen eakcffqvsv flplvsatea
     2461 sdypavsels iekprtasta etprrltpvp gslqeafikr kksfmershq rqkeirnkih
     2521 vsensqiktv kekpsisssv srlkgvnkvr asfpedrktt qalrhqrglr lynqlaevkq
     2581 qkeektkqea yaqnrarake fhkktleklr akntc
//
LOCUS       XP_054226313            2614 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 295 kDa isoform X6 [Homo sapiens].
ACCESSION   XP_054226313
VERSION     XP_054226313.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370338.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2614
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2614
                     /product="centrosomal protein of 295 kDa isoform X6"
                     /calculated_mol_wt=296592
     Region          <27..554
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          2491..2612
                     /region_name="ALMS_motif"
                     /note="ALMS motif; pfam15309"
                     /db_xref="CDD:464634"
     CDS             1..2614
                     /gene="CEP295"
                     /gene_synonym="KIAA1731; SCKL11"
                     /coded_by="XM_054370338.1:120..7964"
                     /db_xref="GeneID:85459"
                     /db_xref="HGNC:HGNC:29366"
                     /db_xref="MIM:617728"
ORIGIN      
        1 mkrkvvnthk lrlspneeaf ilkedyerrr klrllqvreq erdialqire dikqrrnqqf
       61 trlaeelrae weesqtqkiq nleklylasl rsmgeghrqa kenepdldal aqraaerkrk
      121 adlrhkealk vqknqkeill kqktwhikar keallveker sakitslppp pptlfeniev
      181 krisavktns styhhlhtfv nretdtkqpd arlaaeeeak rleelqkqaa qermerfeka
      241 hvrgfqamkk ihlaqnqekl mkelkqlqqe dlarrrqtva qmppqlvelp ykrsemkedw
      301 qrelefafed mynadrkvkg nlilhlepep lptvtnqiqd eeldlsmeqe nlgaaedlpv
      361 teaeicsset dvplvmktqq ipskvlfkkl lnkirsqksl wtiksmsede semittvsei
      421 eskaptvesg tiaskertls sgqeqvvesd tltiesgpla sedkplscgt nsgkeqeine
      481 tlpittvaqs svllhpqeea arirmsarqk qimeieeqkq kqlelleqie qqklrletdc
      541 fraqleeekr kktqptgvgc rkshhyinhl vgiapascpv isdedshrqm irnyqhqllq
      601 qnrlhrqsve tarkqlleyq tmlkgrcpsv sapslitdsv isvpswkser ptaisehwdq
      661 gqrlklspnk yqpiqpiqts kleqdhfqva rqnhfpqrqv ettetlrasd iltnqalesq
      721 ehlrqfsqte tqqrdyklvp kdsetlsral shdrqlisqd arkisetfga ttfqslesqq
      781 lfsensenis yhltepssfv plvpqhsfss lpvkvesgki qepfsamsks tvstshsiis
      841 qmhdrpllps enitaqqgnm kalqeqldlq kkvlqatqea qeqlllckqk eveqqtglsv
      901 flplvtpdss allpsakadl griqessptk nniavssdhh visqlqdkrl slsqpilsqq
      961 nnfkflqeql niqkdslqar reaqevlyvh kqseldrrvc seqaepsfpf qvaqhtftsl
     1021 psadtksgki qeqhssksek glvscqsdip isqdgslsfl qqflplhdsl kllqeqltkq
     1081 rdtlqarhea qvelllhrqr dlgdsksglv ssssspvvvq hsvasqasak aeprriqely
     1141 lsekenvgps chliiptfqd kslsfpqhsl aqqenltilq eqsqiqrvil gakegtqefv
     1201 hteselekri sseqtgtsss lsqvdeserf qecisiksds tiplshpkip rcqerllrvs
     1261 qhmlplqdnl eehqawldte keafhfsqkt qentsseqtg sssfipqlvq lsftslasae
     1321 sgtileplft eseskifssh lqipqlqdrl lrisqliqpq qdnlkalqeq latqreaiil
     1381 arqeareell lhqsewegri speqvdtssl plvpqhsfas lplnesernq epcsinsdni
     1441 vssghseipt lpdgllglsh lvlpqqdnli aleehlhaqt dflpsiektq kelvlskpck
     1501 feekvssehf iqshhgdlqa lqqqldtqkk airsiqevqe elllqrlsel ekrvsseqvc
     1561 sssfvsqvpv adsertqksf ptksndtlps shreiprlqd rllslskpil pqqdnmtaql
     1621 daqrevmysy ekpqeelsln kqrklnkses aehtipslfl pketehsfip lpfaeakpks
     1681 tcelyssqne haappsnpvi pgfqdrllsf sqsvltqqdn lglqkqldlq revlhysqka
     1741 qekllvqrqt alqqqiqkhe etlkdffkds qiskptvend lktqkmgqlr dwfpntqdla
     1801 gndqenirha drnnsddnhl asedtsakqs gehlekdlgr rsskppvakv kcgldlnqhe
     1861 lsaiqevesp aigrtsilgk pgiyedrdpl rvsisreqsf fgsplahdpf sclqlvgqen
     1921 vcgddydeav klkesvvenh avlsyaveee haylgptvkp ddkaktlsye plssatvstg
     1981 sllsyentdl sltdpesfse hmddskqest tskeeetnii ssivpstqdi yqrqnssdvh
     2041 ksllpavdet tcghthfqqm idkyineanl ipektdlqel ehifpnlhhq lfkplephpd
     2101 fdlsssssgi spdnrdfyqr sdssseshca tglskstvyf talrrtsmhs slntspnqqp
     2161 dtnlahvgah sfateniigg seqcfeqlqp eyssqeesqh adlpsifsie ardssqgmkn
     2221 qnypseehte ilqnkkkivh fqlsignlss vysssdeanv fdqlnvqhst pcgsnssecs
     2281 tkhqlesrke smgfeelskr gvvtmlqsqg liednknetc rvldinpqve etdsrlcvrt
     2341 vemgtsiqap yslttqneky fensaetdip kitkklsqlg eselfassgs fslqssipvw
     2401 etetghgime epeltlistt dtsiaemdfa nltleeksen eakcffqvsv flplvsatea
     2461 sdypavsels iekprtaste tprrltpvpg slqeafikrk ksfmershqr qkeirnkihv
     2521 sensqiktvk ekpsisssvs rlkgvnkvra sfpedrkttq alrhqrglrl ynqlaevkqq
     2581 keektkqeay aqnrarakef hkktleklra kntc
//
LOCUS       XP_054226314            2597 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 295 kDa isoform X7 [Homo sapiens].
ACCESSION   XP_054226314
VERSION     XP_054226314.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370339.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2597
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2597
                     /product="centrosomal protein of 295 kDa isoform X7"
                     /calculated_mol_wt=294867
     Region          <27..554
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          2444..2555
                     /region_name="ALMS_motif"
                     /note="ALMS motif; pfam15309"
                     /db_xref="CDD:464634"
     CDS             1..2597
                     /gene="CEP295"
                     /gene_synonym="KIAA1731; SCKL11"
                     /coded_by="XM_054370339.1:120..7913"
                     /db_xref="GeneID:85459"
                     /db_xref="HGNC:HGNC:29366"
                     /db_xref="MIM:617728"
ORIGIN      
        1 mkrkvvnthk lrlspneeaf ilkedyerrr klrllqvreq erdialqire dikqrrnqqf
       61 trlaeelrae weesqtqkiq nleklylasl rsmgeghrqa kenepdldal aqraaerkrk
      121 adlrhkealk vqknqkeill kqktwhikar keallveker sakitslppp pptlfeniev
      181 krisavktns styhhlhtfv nretdtkqpd arlaaeeeak rleelqkqaa qermerfeka
      241 hvrgfqamkk ihlaqnqekl mkelkqlqqe dlarrrqtva qmppqlvelp ykrsemkedw
      301 qrelefafed mynadrkvkg nlilhlepep lptvtnqiqd eeldlsmeqe nlgaaedlpv
      361 teaeicsset dvplvmktqq ipskvlfkkl lnkirsqksl wtiksmsede semittvsei
      421 eskaptvesg tiaskertls sgqeqvvesd tltiesgpla sedkplscgt nsgkeqeine
      481 tlpittvaqs svllhpqeea arirmsarqk qimeieeqkq kqlelleqie qqklrletdc
      541 fraqleeekr kktqptgvgc rkshhyinhl vgiapascpv isdedshrqm irnyqhqllq
      601 qnrlhrqsve tarkqlleyq tmlkgrcpsv sapslitdsv isvpswkser ptaisehwdq
      661 gqrlklspnk yqpiqpiqts kleqdhfqva rqnhfpqrqv ettetlrasd iltnqalesq
      721 ehlrqfsqte tqqrdyklvp kdsetlsral shdrqlisqd arkisetfga ttfqslesqq
      781 lfsensenis yhltepssfv plvpqhsfss lpvkvesgki qepfsamsks tvstshsiis
      841 qmhdrpllps enitaqqgnm kalqeqldlq kkvlqatqea qeqlllckqk eveqqtglsv
      901 flplvtpdss allpsakadl griqessptk nniavssdhh visqlqdkrl slsqpilsqq
      961 nnfkflqeql niqkdslqar reaqevlyvh kqseldrrvc seqaepsfpf qvaqhtftsl
     1021 psadtksgki qeqhssksek glvscqsdip isqdgslsfl qqflplhdsl kllqeqltkq
     1081 rdtlqarhea qvelllhrqr dlgdsksglv ssssspvvvq hsvasqasak aeprriqely
     1141 lsekenvgps chliiptfqd kslsfpqhsl aqqenltilq eqsqiqrvil gakegtqefv
     1201 hteselekri sseqtgtsss lsqvdeserf qecisiksds tiplshpkip rcqerllrvs
     1261 qhmlplqdnl eehqawldte keafhfsqkt qentsseqtg sssfipqlvq lsftslasae
     1321 sgtileplft eseskifssh lqipqlqdrl lrisqliqpq qdnlkalqeq latqreaiil
     1381 arqeareell lhqsewegri speqvdtssl plvpqhsfas lplnesernq epcsinsdni
     1441 vssghseipt lpdgllglsh lvlpqqdnli aleehlhaqt dflpsiektq kelvlskpck
     1501 feekvssehf iqshhgdlqa lqqqldtqkk airsiqevqe elllqrlsel ekrvsseqvc
     1561 sssfvsqvpv adsertqksf ptksndtlps shreiprlqd rllslskpil pqqdnmtaql
     1621 daqrevmysy ekpqeelsln kqrklnkses aehtipslfl pketehsfip lpfaeakpks
     1681 tcelyssqne haappsnpvi pgfqdrllsf sqsvltqqdn lglqkqldlq revlhysqka
     1741 qekllvqrqt alqqqiqkhe etlkdffkds qiskptvend lktqkmgqlr dwfpntqdla
     1801 gndqenirha drnnsddnhl asedtsakqs gkpgiyedrd plrvsisreq sffgsplahd
     1861 pfsclqlvgq envcgddyde avklkesvve nhavlsyave eehaylgptv kpddkaktls
     1921 yeplssatvs tgsllsyent dlsltdpesf sehmddskqe sttskeeetn iissivpstq
     1981 diyqrqnssd vhksllpavd ettcghthfq qmidkyinea nlipektdlq elehifpnlh
     2041 hqlfkpleph pdfdlsssss gispdnrdfy qrsdsssesh catglskstv yftalrrtsm
     2101 hsslntspnq qpdtnlahvg ahsfatenii ggseqcfeql qpeyssqees qhadlpsifs
     2161 ieardssqgm knqnypseeh teilqnkkki vhfqlsignl ssvysssdea nvfdqlnvqh
     2221 stpcgsnsse cstkhqlesr kesmgfeels krgvvtmlqs qgliednkne tcrvldinpq
     2281 veetdsrlcv rtvemgtsiq apyslttqne kyfensaetd ipkitkklsq lgeselfass
     2341 gsfslqssip vwetetghgi meepeltlis ttdtsiaemd fanltleeks eneakcffqv
     2401 svflplvsat easdypavse lsiekprtas taetprrltp vpgslqeafi krkksfmers
     2461 hqrqkeirnk ihvsensqik tvkekpsiss svsrlkgvnk vrasfpedrk ttqalrhqrg
     2521 lrlynqlaev kqqkeektkq eayaqnrara kefhkvsite geglnfssmk yttetqifip
     2581 stentretss qkymltf
//
LOCUS       XP_054226315            2596 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 295 kDa isoform X8 [Homo sapiens].
ACCESSION   XP_054226315
VERSION     XP_054226315.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370340.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2596
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2596
                     /product="centrosomal protein of 295 kDa isoform X8"
                     /calculated_mol_wt=294796
     Region          <27..554
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          2443..2554
                     /region_name="ALMS_motif"
                     /note="ALMS motif; pfam15309"
                     /db_xref="CDD:464634"
     CDS             1..2596
                     /gene="CEP295"
                     /gene_synonym="KIAA1731; SCKL11"
                     /coded_by="XM_054370340.1:120..7910"
                     /db_xref="GeneID:85459"
                     /db_xref="HGNC:HGNC:29366"
                     /db_xref="MIM:617728"
ORIGIN      
        1 mkrkvvnthk lrlspneeaf ilkedyerrr klrllqvreq erdialqire dikqrrnqqf
       61 trlaeelrae weesqtqkiq nleklylasl rsmgeghrqa kenepdldal aqraaerkrk
      121 adlrhkealk vqknqkeill kqktwhikar keallveker sakitslppp pptlfeniev
      181 krisavktns styhhlhtfv nretdtkqpd arlaaeeeak rleelqkqaa qermerfeka
      241 hvrgfqamkk ihlaqnqekl mkelkqlqqe dlarrrqtva qmppqlvelp ykrsemkedw
      301 qrelefafed mynadrkvkg nlilhlepep lptvtnqiqd eeldlsmeqe nlgaaedlpv
      361 teaeicsset dvplvmktqq ipskvlfkkl lnkirsqksl wtiksmsede semittvsei
      421 eskaptvesg tiaskertls sgqeqvvesd tltiesgpla sedkplscgt nsgkeqeine
      481 tlpittvaqs svllhpqeea arirmsarqk qimeieeqkq kqlelleqie qqklrletdc
      541 fraqleeekr kktqptgvgc rkshhyinhl vgiapascpv isdedshrqm irnyqhqllq
      601 qnrlhrqsve tarkqlleyq tmlkgrcpsv sapslitdsv isvpswkser ptaisehwdq
      661 gqrlklspnk yqpiqpiqts kleqdhfqva rqnhfpqrqv ettetlrasd iltnqalesq
      721 ehlrqfsqte tqqrdyklvp kdsetlsral shdrqlisqd arkisetfga ttfqslesqq
      781 lfsensenis yhltepssfv plvpqhsfss lpvkvesgki qepfsamsks tvstshsiis
      841 qmhdrpllps enitaqqgnm kalqeqldlq kkvlqatqea qeqlllckqk eveqqtglsv
      901 flplvtpdss allpsakadl griqessptk nniavssdhh visqlqdkrl slsqpilsqq
      961 nnfkflqeql niqkdslqar reaqevlyvh kqseldrrvc seqaepsfpf qvaqhtftsl
     1021 psadtksgki qeqhssksek glvscqsdip isqdgslsfl qqflplhdsl kllqeqltkq
     1081 rdtlqarhea qvelllhrqr dlgdsksglv ssssspvvvq hsvasqasak aeprriqely
     1141 lsekenvgps chliiptfqd kslsfpqhsl aqqenltilq eqsqiqrvil gakegtqefv
     1201 hteselekri sseqtgtsss lsqvdeserf qecisiksds tiplshpkip rcqerllrvs
     1261 qhmlplqdnl eehqawldte keafhfsqkt qentsseqtg sssfipqlvq lsftslasae
     1321 sgtileplft eseskifssh lqipqlqdrl lrisqliqpq qdnlkalqeq latqreaiil
     1381 arqeareell lhqsewegri speqvdtssl plvpqhsfas lplnesernq epcsinsdni
     1441 vssghseipt lpdgllglsh lvlpqqdnli aleehlhaqt dflpsiektq kelvlskpck
     1501 feekvssehf iqshhgdlqa lqqqldtqkk airsiqevqe elllqrlsel ekrvsseqvc
     1561 sssfvsqvpv adsertqksf ptksndtlps shreiprlqd rllslskpil pqqdnmtaql
     1621 daqrevmysy ekpqeelsln kqrklnkses aehtipslfl pketehsfip lpfaeakpks
     1681 tcelyssqne haappsnpvi pgfqdrllsf sqsvltqqdn lglqkqldlq revlhysqka
     1741 qekllvqrqt alqqqiqkhe etlkdffkds qiskptvend lktqkmgqlr dwfpntqdla
     1801 gndqenirha drnnsddnhl asedtsakqs gkpgiyedrd plrvsisreq sffgsplahd
     1861 pfsclqlvgq envcgddyde avklkesvve nhavlsyave eehaylgptv kpddkaktls
     1921 yeplssatvs tgsllsyent dlsltdpesf sehmddskqe sttskeeetn iissivpstq
     1981 diyqrqnssd vhksllpavd ettcghthfq qmidkyinea nlipektdlq elehifpnlh
     2041 hqlfkpleph pdfdlsssss gispdnrdfy qrsdsssesh catglskstv yftalrrtsm
     2101 hsslntspnq qpdtnlahvg ahsfatenii ggseqcfeql qpeyssqees qhadlpsifs
     2161 ieardssqgm knqnypseeh teilqnkkki vhfqlsignl ssvysssdea nvfdqlnvqh
     2221 stpcgsnsse cstkhqlesr kesmgfeels krgvvtmlqs qgliednkne tcrvldinpq
     2281 veetdsrlcv rtvemgtsiq apyslttqne kyfensaetd ipkitkklsq lgeselfass
     2341 gsfslqssip vwetetghgi meepeltlis ttdtsiaemd fanltleeks eneakcffqv
     2401 svflplvsat easdypavse lsiekprtas tetprrltpv pgslqeafik rkksfmersh
     2461 qrqkeirnki hvsensqikt vkekpsisss vsrlkgvnkv rasfpedrkt tqalrhqrgl
     2521 rlynqlaevk qqkeektkqe ayaqnrarak efhkvsiteg eglnfssmky ttetqifips
     2581 tentretssq kymltf
//
LOCUS       XP_054226316            2584 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 295 kDa isoform X9 [Homo sapiens].
ACCESSION   XP_054226316
VERSION     XP_054226316.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370341.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2584
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2584
                     /product="centrosomal protein of 295 kDa isoform X9"
                     /calculated_mol_wt=293321
     Region          <27..554
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          2431..2542
                     /region_name="ALMS_motif"
                     /note="ALMS motif; pfam15309"
                     /db_xref="CDD:464634"
     CDS             1..2584
                     /gene="CEP295"
                     /gene_synonym="KIAA1731; SCKL11"
                     /coded_by="XM_054370341.1:120..7874"
                     /db_xref="GeneID:85459"
                     /db_xref="HGNC:HGNC:29366"
                     /db_xref="MIM:617728"
ORIGIN      
        1 mkrkvvnthk lrlspneeaf ilkedyerrr klrllqvreq erdialqire dikqrrnqqf
       61 trlaeelrae weesqtqkiq nleklylasl rsmgeghrqa kenepdldal aqraaerkrk
      121 adlrhkealk vqknqkeill kqktwhikar keallveker sakitslppp pptlfeniev
      181 krisavktns styhhlhtfv nretdtkqpd arlaaeeeak rleelqkqaa qermerfeka
      241 hvrgfqamkk ihlaqnqekl mkelkqlqqe dlarrrqtva qmppqlvelp ykrsemkedw
      301 qrelefafed mynadrkvkg nlilhlepep lptvtnqiqd eeldlsmeqe nlgaaedlpv
      361 teaeicsset dvplvmktqq ipskvlfkkl lnkirsqksl wtiksmsede semittvsei
      421 eskaptvesg tiaskertls sgqeqvvesd tltiesgpla sedkplscgt nsgkeqeine
      481 tlpittvaqs svllhpqeea arirmsarqk qimeieeqkq kqlelleqie qqklrletdc
      541 fraqleeekr kktqptgvgi apascpvisd edshrqmirn yqhqllqqnr lhrqsvetar
      601 kqlleyqtml kgrcpsvsap slitdsvisv pswkserpta isehwdqgqr lklspnkyqp
      661 iqpiqtskle qdhfqvarqn hfpqrqvett etlrasdilt nqalesqehl rqfsqtetqq
      721 rdyklvpkds etlsralshd rqlisqdark isetfgattf qslesqqlfs ensenisyhl
      781 tepssfvplv pqhsfsslpv kvesgkiqep fsamskstvs tshsiisqmh drpllpseni
      841 taqqgnmkal qeqldlqkkv lqatqeaqeq lllckqkeve qqtglsvflp lvtpdssall
      901 psakadlgri qessptknni avssdhhvis qlqdkrlsls qpilsqqnnf kflqeqlniq
      961 kdslqarrea qevlyvhkqs eldrrvcseq aepsfpfqva qhtftslpsa dtksgkiqeq
     1021 hssksekglv scqsdipisq dgslsflqqf lplhdslkll qeqltkqrdt lqarheaqve
     1081 lllhrqrdlg dsksglvsss sspvvvqhsv asqasakaep rriqelylse kenvgpschl
     1141 iiptfqdksl sfpqhslaqq enltilqeqs qiqrvilgak egtqefvhte selekrisse
     1201 qtgtssslsq vdeserfqec isiksdstip lshpkiprcq erllrvsqhm lplqdnleeh
     1261 qawldtekea fhfsqktqen tsseqtgsss fipqlvqlsf tslasaesgt ileplftese
     1321 skifsshlqi pqlqdrllri sqliqpqqdn lkalqeqlat qreaiilarq eareelllhq
     1381 sewegrispe qvdtsslplv pqhsfaslpl nesernqepc sinsdnivss ghseiptlpd
     1441 gllglshlvl pqqdnliale ehlhaqtdfl psiektqkel vlskpckfee kvssehfiqs
     1501 hhgdlqalqq qldtqkkair siqevqeell lqrlselekr vsseqvcsss fvsqvpvads
     1561 ertqksfptk sndtlpsshr eiprlqdrll slskpilpqq dnmtaqldaq revmysyekp
     1621 qeelslnkqr klnksesaeh tipslflpke tehsfiplpf aeakpkstce lyssqnehaa
     1681 ppsnpvipgf qdrllsfsqs vltqqdnlgl qkqldlqrev lhysqkaqek llvqrqtalq
     1741 qqiqkheetl kdffkdsqis kptvendlkt qkmgqlrdwf pntqdlagnd qenirhadrn
     1801 nsddnhlase dtsakqsgkp giyedrdplr vsisreqsff gsplahdpfs clqlvgqenv
     1861 cgddydeavk lkesvvenha vlsyaveeeh aylgptvkpd dkaktlsyep lssatvstgs
     1921 llsyentdls ltdpesfseh mddskqestt skeeetniis sivpstqdiy qrqnssdvhk
     1981 sllpavdett cghthfqqmi dkyineanli pektdlqele hifpnlhhql fkplephpdf
     2041 dlsssssgis pdnrdfyqrs dssseshcat glskstvyft alrrtsmhss lntspnqqpd
     2101 tnlahvgahs fateniiggs eqcfeqlqpe yssqeesqha dlpsifsiea rdssqgmknq
     2161 nypseehtei lqnkkkivhf qlsignlssv ysssdeanvf dqlnvqhstp cgsnssecst
     2221 khqlesrkes mgfeelskrg vvtmlqsqgl iednknetcr vldinpqvee tdsrlcvrtv
     2281 emgtsiqapy slttqnekyf ensaetdipk itkklsqlge selfassgsf slqssipvwe
     2341 tetghgimee peltlisttd tsiaemdfan ltleeksene akcffqvsvf lplvsateas
     2401 dypavselsi ekprtastae tprrltpvpg slqeafikrk ksfmershqr qkeirnkihv
     2461 sensqiktvk ekpsisssvs rlkgvnkvra sfpedrkttq alrhqrglrl ynqlaevkqq
     2521 keektkqeay aqnrarakef hkvsitegeg lnfssmkytt etqifipste ntretssqky
     2581 mltf
//
LOCUS       XP_054226317            2583 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 295 kDa isoform X10 [Homo sapiens].
ACCESSION   XP_054226317
VERSION     XP_054226317.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370342.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2583
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2583
                     /product="centrosomal protein of 295 kDa isoform X10"
                     /calculated_mol_wt=293250
     Region          <27..554
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          2430..2541
                     /region_name="ALMS_motif"
                     /note="ALMS motif; pfam15309"
                     /db_xref="CDD:464634"
     CDS             1..2583
                     /gene="CEP295"
                     /gene_synonym="KIAA1731; SCKL11"
                     /coded_by="XM_054370342.1:120..7871"
                     /db_xref="GeneID:85459"
                     /db_xref="HGNC:HGNC:29366"
                     /db_xref="MIM:617728"
ORIGIN      
        1 mkrkvvnthk lrlspneeaf ilkedyerrr klrllqvreq erdialqire dikqrrnqqf
       61 trlaeelrae weesqtqkiq nleklylasl rsmgeghrqa kenepdldal aqraaerkrk
      121 adlrhkealk vqknqkeill kqktwhikar keallveker sakitslppp pptlfeniev
      181 krisavktns styhhlhtfv nretdtkqpd arlaaeeeak rleelqkqaa qermerfeka
      241 hvrgfqamkk ihlaqnqekl mkelkqlqqe dlarrrqtva qmppqlvelp ykrsemkedw
      301 qrelefafed mynadrkvkg nlilhlepep lptvtnqiqd eeldlsmeqe nlgaaedlpv
      361 teaeicsset dvplvmktqq ipskvlfkkl lnkirsqksl wtiksmsede semittvsei
      421 eskaptvesg tiaskertls sgqeqvvesd tltiesgpla sedkplscgt nsgkeqeine
      481 tlpittvaqs svllhpqeea arirmsarqk qimeieeqkq kqlelleqie qqklrletdc
      541 fraqleeekr kktqptgvgi apascpvisd edshrqmirn yqhqllqqnr lhrqsvetar
      601 kqlleyqtml kgrcpsvsap slitdsvisv pswkserpta isehwdqgqr lklspnkyqp
      661 iqpiqtskle qdhfqvarqn hfpqrqvett etlrasdilt nqalesqehl rqfsqtetqq
      721 rdyklvpkds etlsralshd rqlisqdark isetfgattf qslesqqlfs ensenisyhl
      781 tepssfvplv pqhsfsslpv kvesgkiqep fsamskstvs tshsiisqmh drpllpseni
      841 taqqgnmkal qeqldlqkkv lqatqeaqeq lllckqkeve qqtglsvflp lvtpdssall
      901 psakadlgri qessptknni avssdhhvis qlqdkrlsls qpilsqqnnf kflqeqlniq
      961 kdslqarrea qevlyvhkqs eldrrvcseq aepsfpfqva qhtftslpsa dtksgkiqeq
     1021 hssksekglv scqsdipisq dgslsflqqf lplhdslkll qeqltkqrdt lqarheaqve
     1081 lllhrqrdlg dsksglvsss sspvvvqhsv asqasakaep rriqelylse kenvgpschl
     1141 iiptfqdksl sfpqhslaqq enltilqeqs qiqrvilgak egtqefvhte selekrisse
     1201 qtgtssslsq vdeserfqec isiksdstip lshpkiprcq erllrvsqhm lplqdnleeh
     1261 qawldtekea fhfsqktqen tsseqtgsss fipqlvqlsf tslasaesgt ileplftese
     1321 skifsshlqi pqlqdrllri sqliqpqqdn lkalqeqlat qreaiilarq eareelllhq
     1381 sewegrispe qvdtsslplv pqhsfaslpl nesernqepc sinsdnivss ghseiptlpd
     1441 gllglshlvl pqqdnliale ehlhaqtdfl psiektqkel vlskpckfee kvssehfiqs
     1501 hhgdlqalqq qldtqkkair siqevqeell lqrlselekr vsseqvcsss fvsqvpvads
     1561 ertqksfptk sndtlpsshr eiprlqdrll slskpilpqq dnmtaqldaq revmysyekp
     1621 qeelslnkqr klnksesaeh tipslflpke tehsfiplpf aeakpkstce lyssqnehaa
     1681 ppsnpvipgf qdrllsfsqs vltqqdnlgl qkqldlqrev lhysqkaqek llvqrqtalq
     1741 qqiqkheetl kdffkdsqis kptvendlkt qkmgqlrdwf pntqdlagnd qenirhadrn
     1801 nsddnhlase dtsakqsgkp giyedrdplr vsisreqsff gsplahdpfs clqlvgqenv
     1861 cgddydeavk lkesvvenha vlsyaveeeh aylgptvkpd dkaktlsyep lssatvstgs
     1921 llsyentdls ltdpesfseh mddskqestt skeeetniis sivpstqdiy qrqnssdvhk
     1981 sllpavdett cghthfqqmi dkyineanli pektdlqele hifpnlhhql fkplephpdf
     2041 dlsssssgis pdnrdfyqrs dssseshcat glskstvyft alrrtsmhss lntspnqqpd
     2101 tnlahvgahs fateniiggs eqcfeqlqpe yssqeesqha dlpsifsiea rdssqgmknq
     2161 nypseehtei lqnkkkivhf qlsignlssv ysssdeanvf dqlnvqhstp cgsnssecst
     2221 khqlesrkes mgfeelskrg vvtmlqsqgl iednknetcr vldinpqvee tdsrlcvrtv
     2281 emgtsiqapy slttqnekyf ensaetdipk itkklsqlge selfassgsf slqssipvwe
     2341 tetghgimee peltlisttd tsiaemdfan ltleeksene akcffqvsvf lplvsateas
     2401 dypavselsi ekprtastet prrltpvpgs lqeafikrkk sfmershqrq keirnkihvs
     2461 ensqiktvke kpsisssvsr lkgvnkvras fpedrkttqa lrhqrglrly nqlaevkqqk
     2521 eektkqeaya qnrarakefh kvsitegegl nfssmkytte tqifipsten tretssqkym
     2581 ltf
//
LOCUS       XP_054226318            2567 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 295 kDa isoform X11 [Homo sapiens].
ACCESSION   XP_054226318
VERSION     XP_054226318.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370343.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2567
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2567
                     /product="centrosomal protein of 295 kDa isoform X11"
                     /calculated_mol_wt=291473
     Region          <27..554
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          2444..2565
                     /region_name="ALMS_motif"
                     /note="ALMS motif; pfam15309"
                     /db_xref="CDD:464634"
     CDS             1..2567
                     /gene="CEP295"
                     /gene_synonym="KIAA1731; SCKL11"
                     /coded_by="XM_054370343.1:120..7823"
                     /db_xref="GeneID:85459"
                     /db_xref="HGNC:HGNC:29366"
                     /db_xref="MIM:617728"
ORIGIN      
        1 mkrkvvnthk lrlspneeaf ilkedyerrr klrllqvreq erdialqire dikqrrnqqf
       61 trlaeelrae weesqtqkiq nleklylasl rsmgeghrqa kenepdldal aqraaerkrk
      121 adlrhkealk vqknqkeill kqktwhikar keallveker sakitslppp pptlfeniev
      181 krisavktns styhhlhtfv nretdtkqpd arlaaeeeak rleelqkqaa qermerfeka
      241 hvrgfqamkk ihlaqnqekl mkelkqlqqe dlarrrqtva qmppqlvelp ykrsemkedw
      301 qrelefafed mynadrkvkg nlilhlepep lptvtnqiqd eeldlsmeqe nlgaaedlpv
      361 teaeicsset dvplvmktqq ipskvlfkkl lnkirsqksl wtiksmsede semittvsei
      421 eskaptvesg tiaskertls sgqeqvvesd tltiesgpla sedkplscgt nsgkeqeine
      481 tlpittvaqs svllhpqeea arirmsarqk qimeieeqkq kqlelleqie qqklrletdc
      541 fraqleeekr kktqptgvgc rkshhyinhl vgiapascpv isdedshrqm irnyqhqllq
      601 qnrlhrqsve tarkqlleyq tmlkgrcpsv sapslitdsv isvpswkser ptaisehwdq
      661 gqrlklspnk yqpiqpiqts kleqdhfqva rqnhfpqrqv ettetlrasd iltnqalesq
      721 ehlrqfsqte tqqrdyklvp kdsetlsral shdrqlisqd arkisetfga ttfqslesqq
      781 lfsensenis yhltepssfv plvpqhsfss lpvkvesgki qepfsamsks tvstshsiis
      841 qmhdrpllps enitaqqgnm kalqeqldlq kkvlqatqea qeqlllckqk eveqqtglsv
      901 flplvtpdss allpsakadl griqessptk nniavssdhh visqlqdkrl slsqpilsqq
      961 nnfkflqeql niqkdslqar reaqevlyvh kqseldrrvc seqaepsfpf qvaqhtftsl
     1021 psadtksgki qeqhssksek glvscqsdip isqdgslsfl qqflplhdsl kllqeqltkq
     1081 rdtlqarhea qvelllhrqr dlgdsksglv ssssspvvvq hsvasqasak aeprriqely
     1141 lsekenvgps chliiptfqd kslsfpqhsl aqqenltilq eqsqiqrvil gakegtqefv
     1201 hteselekri sseqtgtsss lsqvdeserf qecisiksds tiplshpkip rcqerllrvs
     1261 qhmlplqdnl eehqawldte keafhfsqkt qentsseqtg sssfipqlvq lsftslasae
     1321 sgtileplft eseskifssh lqipqlqdrl lrisqliqpq qdnlkalqeq latqreaiil
     1381 arqeareell lhqsewegri speqvdtssl plvpqhsfas lplnesernq epcsinsdni
     1441 vssghseipt lpdgllglsh lvlpqqdnli aleehlhaqt dflpsiektq kelvlskpck
     1501 feekvssehf iqshhgdlqa lqqqldtqkk airsiqevqe elllqrlsel ekrvsseqvc
     1561 sssfvsqvpv adsertqksf ptksndtlps shreiprlqd rllslskpil pqqdnmtaql
     1621 daqrevmysy ekpqeelsln kqrklnkses aehtipslfl pketehsfip lpfaeakpks
     1681 tcelyssqne haappsnpvi pgfqdrllsf sqsvltqqdn lglqkqldlq revlhysqka
     1741 qekllvqrqt alqqqiqkhe etlkdffkds qiskptvend lktqkmgqlr dwfpntqdla
     1801 gndqenirha drnnsddnhl asedtsakqs gkpgiyedrd plrvsisreq sffgsplahd
     1861 pfsclqlvgq envcgddyde avklkesvve nhavlsyave eehaylgptv kpddkaktls
     1921 yeplssatvs tgsllsyent dlsltdpesf sehmddskqe sttskeeetn iissivpstq
     1981 diyqrqnssd vhksllpavd ettcghthfq qmidkyinea nlipektdlq elehifpnlh
     2041 hqlfkpleph pdfdlsssss gispdnrdfy qrsdsssesh catglskstv yftalrrtsm
     2101 hsslntspnq qpdtnlahvg ahsfatenii ggseqcfeql qpeyssqees qhadlpsifs
     2161 ieardssqgm knqnypseeh teilqnkkki vhfqlsignl ssvysssdea nvfdqlnvqh
     2221 stpcgsnsse cstkhqlesr kesmgfeels krgvvtmlqs qgliednkne tcrvldinpq
     2281 veetdsrlcv rtvemgtsiq apyslttqne kyfensaetd ipkitkklsq lgeselfass
     2341 gsfslqssip vwetetghgi meepeltlis ttdtsiaemd fanltleeks eneakcffqv
     2401 svflplvsat easdypavse lsiekprtas taetprrltp vpgslqeafi krkksfmers
     2461 hqrqkeirnk ihvsensqik tvkekpsiss svsrlkgvnk vrasfpedrk ttqalrhqrg
     2521 lrlynqlaev kqqkeektkq eayaqnrara kefhkktlek lrakntc
//
LOCUS       XP_054226319            2566 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 295 kDa isoform X12 [Homo sapiens].
ACCESSION   XP_054226319
VERSION     XP_054226319.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370344.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2566
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2566
                     /product="centrosomal protein of 295 kDa isoform X12"
                     /calculated_mol_wt=291402
     Region          <27..554
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          2443..2564
                     /region_name="ALMS_motif"
                     /note="ALMS motif; pfam15309"
                     /db_xref="CDD:464634"
     CDS             1..2566
                     /gene="CEP295"
                     /gene_synonym="KIAA1731; SCKL11"
                     /coded_by="XM_054370344.1:120..7820"
                     /db_xref="GeneID:85459"
                     /db_xref="HGNC:HGNC:29366"
                     /db_xref="MIM:617728"
ORIGIN      
        1 mkrkvvnthk lrlspneeaf ilkedyerrr klrllqvreq erdialqire dikqrrnqqf
       61 trlaeelrae weesqtqkiq nleklylasl rsmgeghrqa kenepdldal aqraaerkrk
      121 adlrhkealk vqknqkeill kqktwhikar keallveker sakitslppp pptlfeniev
      181 krisavktns styhhlhtfv nretdtkqpd arlaaeeeak rleelqkqaa qermerfeka
      241 hvrgfqamkk ihlaqnqekl mkelkqlqqe dlarrrqtva qmppqlvelp ykrsemkedw
      301 qrelefafed mynadrkvkg nlilhlepep lptvtnqiqd eeldlsmeqe nlgaaedlpv
      361 teaeicsset dvplvmktqq ipskvlfkkl lnkirsqksl wtiksmsede semittvsei
      421 eskaptvesg tiaskertls sgqeqvvesd tltiesgpla sedkplscgt nsgkeqeine
      481 tlpittvaqs svllhpqeea arirmsarqk qimeieeqkq kqlelleqie qqklrletdc
      541 fraqleeekr kktqptgvgc rkshhyinhl vgiapascpv isdedshrqm irnyqhqllq
      601 qnrlhrqsve tarkqlleyq tmlkgrcpsv sapslitdsv isvpswkser ptaisehwdq
      661 gqrlklspnk yqpiqpiqts kleqdhfqva rqnhfpqrqv ettetlrasd iltnqalesq
      721 ehlrqfsqte tqqrdyklvp kdsetlsral shdrqlisqd arkisetfga ttfqslesqq
      781 lfsensenis yhltepssfv plvpqhsfss lpvkvesgki qepfsamsks tvstshsiis
      841 qmhdrpllps enitaqqgnm kalqeqldlq kkvlqatqea qeqlllckqk eveqqtglsv
      901 flplvtpdss allpsakadl griqessptk nniavssdhh visqlqdkrl slsqpilsqq
      961 nnfkflqeql niqkdslqar reaqevlyvh kqseldrrvc seqaepsfpf qvaqhtftsl
     1021 psadtksgki qeqhssksek glvscqsdip isqdgslsfl qqflplhdsl kllqeqltkq
     1081 rdtlqarhea qvelllhrqr dlgdsksglv ssssspvvvq hsvasqasak aeprriqely
     1141 lsekenvgps chliiptfqd kslsfpqhsl aqqenltilq eqsqiqrvil gakegtqefv
     1201 hteselekri sseqtgtsss lsqvdeserf qecisiksds tiplshpkip rcqerllrvs
     1261 qhmlplqdnl eehqawldte keafhfsqkt qentsseqtg sssfipqlvq lsftslasae
     1321 sgtileplft eseskifssh lqipqlqdrl lrisqliqpq qdnlkalqeq latqreaiil
     1381 arqeareell lhqsewegri speqvdtssl plvpqhsfas lplnesernq epcsinsdni
     1441 vssghseipt lpdgllglsh lvlpqqdnli aleehlhaqt dflpsiektq kelvlskpck
     1501 feekvssehf iqshhgdlqa lqqqldtqkk airsiqevqe elllqrlsel ekrvsseqvc
     1561 sssfvsqvpv adsertqksf ptksndtlps shreiprlqd rllslskpil pqqdnmtaql
     1621 daqrevmysy ekpqeelsln kqrklnkses aehtipslfl pketehsfip lpfaeakpks
     1681 tcelyssqne haappsnpvi pgfqdrllsf sqsvltqqdn lglqkqldlq revlhysqka
     1741 qekllvqrqt alqqqiqkhe etlkdffkds qiskptvend lktqkmgqlr dwfpntqdla
     1801 gndqenirha drnnsddnhl asedtsakqs gkpgiyedrd plrvsisreq sffgsplahd
     1861 pfsclqlvgq envcgddyde avklkesvve nhavlsyave eehaylgptv kpddkaktls
     1921 yeplssatvs tgsllsyent dlsltdpesf sehmddskqe sttskeeetn iissivpstq
     1981 diyqrqnssd vhksllpavd ettcghthfq qmidkyinea nlipektdlq elehifpnlh
     2041 hqlfkpleph pdfdlsssss gispdnrdfy qrsdsssesh catglskstv yftalrrtsm
     2101 hsslntspnq qpdtnlahvg ahsfatenii ggseqcfeql qpeyssqees qhadlpsifs
     2161 ieardssqgm knqnypseeh teilqnkkki vhfqlsignl ssvysssdea nvfdqlnvqh
     2221 stpcgsnsse cstkhqlesr kesmgfeels krgvvtmlqs qgliednkne tcrvldinpq
     2281 veetdsrlcv rtvemgtsiq apyslttqne kyfensaetd ipkitkklsq lgeselfass
     2341 gsfslqssip vwetetghgi meepeltlis ttdtsiaemd fanltleeks eneakcffqv
     2401 svflplvsat easdypavse lsiekprtas tetprrltpv pgslqeafik rkksfmersh
     2461 qrqkeirnki hvsensqikt vkekpsisss vsrlkgvnkv rasfpedrkt tqalrhqrgl
     2521 rlynqlaevk qqkeektkqe ayaqnrarak efhkktlekl rakntc
//
LOCUS       XP_054226320            2554 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 295 kDa isoform X13 [Homo sapiens].
ACCESSION   XP_054226320
VERSION     XP_054226320.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370345.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2554
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2554
                     /product="centrosomal protein of 295 kDa isoform X13"
                     /calculated_mol_wt=289928
     Region          <27..554
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          2431..2552
                     /region_name="ALMS_motif"
                     /note="ALMS motif; pfam15309"
                     /db_xref="CDD:464634"
     CDS             1..2554
                     /gene="CEP295"
                     /gene_synonym="KIAA1731; SCKL11"
                     /coded_by="XM_054370345.1:120..7784"
                     /db_xref="GeneID:85459"
                     /db_xref="HGNC:HGNC:29366"
                     /db_xref="MIM:617728"
ORIGIN      
        1 mkrkvvnthk lrlspneeaf ilkedyerrr klrllqvreq erdialqire dikqrrnqqf
       61 trlaeelrae weesqtqkiq nleklylasl rsmgeghrqa kenepdldal aqraaerkrk
      121 adlrhkealk vqknqkeill kqktwhikar keallveker sakitslppp pptlfeniev
      181 krisavktns styhhlhtfv nretdtkqpd arlaaeeeak rleelqkqaa qermerfeka
      241 hvrgfqamkk ihlaqnqekl mkelkqlqqe dlarrrqtva qmppqlvelp ykrsemkedw
      301 qrelefafed mynadrkvkg nlilhlepep lptvtnqiqd eeldlsmeqe nlgaaedlpv
      361 teaeicsset dvplvmktqq ipskvlfkkl lnkirsqksl wtiksmsede semittvsei
      421 eskaptvesg tiaskertls sgqeqvvesd tltiesgpla sedkplscgt nsgkeqeine
      481 tlpittvaqs svllhpqeea arirmsarqk qimeieeqkq kqlelleqie qqklrletdc
      541 fraqleeekr kktqptgvgi apascpvisd edshrqmirn yqhqllqqnr lhrqsvetar
      601 kqlleyqtml kgrcpsvsap slitdsvisv pswkserpta isehwdqgqr lklspnkyqp
      661 iqpiqtskle qdhfqvarqn hfpqrqvett etlrasdilt nqalesqehl rqfsqtetqq
      721 rdyklvpkds etlsralshd rqlisqdark isetfgattf qslesqqlfs ensenisyhl
      781 tepssfvplv pqhsfsslpv kvesgkiqep fsamskstvs tshsiisqmh drpllpseni
      841 taqqgnmkal qeqldlqkkv lqatqeaqeq lllckqkeve qqtglsvflp lvtpdssall
      901 psakadlgri qessptknni avssdhhvis qlqdkrlsls qpilsqqnnf kflqeqlniq
      961 kdslqarrea qevlyvhkqs eldrrvcseq aepsfpfqva qhtftslpsa dtksgkiqeq
     1021 hssksekglv scqsdipisq dgslsflqqf lplhdslkll qeqltkqrdt lqarheaqve
     1081 lllhrqrdlg dsksglvsss sspvvvqhsv asqasakaep rriqelylse kenvgpschl
     1141 iiptfqdksl sfpqhslaqq enltilqeqs qiqrvilgak egtqefvhte selekrisse
     1201 qtgtssslsq vdeserfqec isiksdstip lshpkiprcq erllrvsqhm lplqdnleeh
     1261 qawldtekea fhfsqktqen tsseqtgsss fipqlvqlsf tslasaesgt ileplftese
     1321 skifsshlqi pqlqdrllri sqliqpqqdn lkalqeqlat qreaiilarq eareelllhq
     1381 sewegrispe qvdtsslplv pqhsfaslpl nesernqepc sinsdnivss ghseiptlpd
     1441 gllglshlvl pqqdnliale ehlhaqtdfl psiektqkel vlskpckfee kvssehfiqs
     1501 hhgdlqalqq qldtqkkair siqevqeell lqrlselekr vsseqvcsss fvsqvpvads
     1561 ertqksfptk sndtlpsshr eiprlqdrll slskpilpqq dnmtaqldaq revmysyekp
     1621 qeelslnkqr klnksesaeh tipslflpke tehsfiplpf aeakpkstce lyssqnehaa
     1681 ppsnpvipgf qdrllsfsqs vltqqdnlgl qkqldlqrev lhysqkaqek llvqrqtalq
     1741 qqiqkheetl kdffkdsqis kptvendlkt qkmgqlrdwf pntqdlagnd qenirhadrn
     1801 nsddnhlase dtsakqsgkp giyedrdplr vsisreqsff gsplahdpfs clqlvgqenv
     1861 cgddydeavk lkesvvenha vlsyaveeeh aylgptvkpd dkaktlsyep lssatvstgs
     1921 llsyentdls ltdpesfseh mddskqestt skeeetniis sivpstqdiy qrqnssdvhk
     1981 sllpavdett cghthfqqmi dkyineanli pektdlqele hifpnlhhql fkplephpdf
     2041 dlsssssgis pdnrdfyqrs dssseshcat glskstvyft alrrtsmhss lntspnqqpd
     2101 tnlahvgahs fateniiggs eqcfeqlqpe yssqeesqha dlpsifsiea rdssqgmknq
     2161 nypseehtei lqnkkkivhf qlsignlssv ysssdeanvf dqlnvqhstp cgsnssecst
     2221 khqlesrkes mgfeelskrg vvtmlqsqgl iednknetcr vldinpqvee tdsrlcvrtv
     2281 emgtsiqapy slttqnekyf ensaetdipk itkklsqlge selfassgsf slqssipvwe
     2341 tetghgimee peltlisttd tsiaemdfan ltleeksene akcffqvsvf lplvsateas
     2401 dypavselsi ekprtastae tprrltpvpg slqeafikrk ksfmershqr qkeirnkihv
     2461 sensqiktvk ekpsisssvs rlkgvnkvra sfpedrkttq alrhqrglrl ynqlaevkqq
     2521 keektkqeay aqnrarakef hkktleklra kntc
//
LOCUS       XP_054226321            2553 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 295 kDa isoform X14 [Homo sapiens].
ACCESSION   XP_054226321
VERSION     XP_054226321.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370346.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2553
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2553
                     /product="centrosomal protein of 295 kDa isoform X14"
                     /calculated_mol_wt=289857
     Region          <27..554
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          2430..2551
                     /region_name="ALMS_motif"
                     /note="ALMS motif; pfam15309"
                     /db_xref="CDD:464634"
     CDS             1..2553
                     /gene="CEP295"
                     /gene_synonym="KIAA1731; SCKL11"
                     /coded_by="XM_054370346.1:120..7781"
                     /db_xref="GeneID:85459"
                     /db_xref="HGNC:HGNC:29366"
                     /db_xref="MIM:617728"
ORIGIN      
        1 mkrkvvnthk lrlspneeaf ilkedyerrr klrllqvreq erdialqire dikqrrnqqf
       61 trlaeelrae weesqtqkiq nleklylasl rsmgeghrqa kenepdldal aqraaerkrk
      121 adlrhkealk vqknqkeill kqktwhikar keallveker sakitslppp pptlfeniev
      181 krisavktns styhhlhtfv nretdtkqpd arlaaeeeak rleelqkqaa qermerfeka
      241 hvrgfqamkk ihlaqnqekl mkelkqlqqe dlarrrqtva qmppqlvelp ykrsemkedw
      301 qrelefafed mynadrkvkg nlilhlepep lptvtnqiqd eeldlsmeqe nlgaaedlpv
      361 teaeicsset dvplvmktqq ipskvlfkkl lnkirsqksl wtiksmsede semittvsei
      421 eskaptvesg tiaskertls sgqeqvvesd tltiesgpla sedkplscgt nsgkeqeine
      481 tlpittvaqs svllhpqeea arirmsarqk qimeieeqkq kqlelleqie qqklrletdc
      541 fraqleeekr kktqptgvgi apascpvisd edshrqmirn yqhqllqqnr lhrqsvetar
      601 kqlleyqtml kgrcpsvsap slitdsvisv pswkserpta isehwdqgqr lklspnkyqp
      661 iqpiqtskle qdhfqvarqn hfpqrqvett etlrasdilt nqalesqehl rqfsqtetqq
      721 rdyklvpkds etlsralshd rqlisqdark isetfgattf qslesqqlfs ensenisyhl
      781 tepssfvplv pqhsfsslpv kvesgkiqep fsamskstvs tshsiisqmh drpllpseni
      841 taqqgnmkal qeqldlqkkv lqatqeaqeq lllckqkeve qqtglsvflp lvtpdssall
      901 psakadlgri qessptknni avssdhhvis qlqdkrlsls qpilsqqnnf kflqeqlniq
      961 kdslqarrea qevlyvhkqs eldrrvcseq aepsfpfqva qhtftslpsa dtksgkiqeq
     1021 hssksekglv scqsdipisq dgslsflqqf lplhdslkll qeqltkqrdt lqarheaqve
     1081 lllhrqrdlg dsksglvsss sspvvvqhsv asqasakaep rriqelylse kenvgpschl
     1141 iiptfqdksl sfpqhslaqq enltilqeqs qiqrvilgak egtqefvhte selekrisse
     1201 qtgtssslsq vdeserfqec isiksdstip lshpkiprcq erllrvsqhm lplqdnleeh
     1261 qawldtekea fhfsqktqen tsseqtgsss fipqlvqlsf tslasaesgt ileplftese
     1321 skifsshlqi pqlqdrllri sqliqpqqdn lkalqeqlat qreaiilarq eareelllhq
     1381 sewegrispe qvdtsslplv pqhsfaslpl nesernqepc sinsdnivss ghseiptlpd
     1441 gllglshlvl pqqdnliale ehlhaqtdfl psiektqkel vlskpckfee kvssehfiqs
     1501 hhgdlqalqq qldtqkkair siqevqeell lqrlselekr vsseqvcsss fvsqvpvads
     1561 ertqksfptk sndtlpsshr eiprlqdrll slskpilpqq dnmtaqldaq revmysyekp
     1621 qeelslnkqr klnksesaeh tipslflpke tehsfiplpf aeakpkstce lyssqnehaa
     1681 ppsnpvipgf qdrllsfsqs vltqqdnlgl qkqldlqrev lhysqkaqek llvqrqtalq
     1741 qqiqkheetl kdffkdsqis kptvendlkt qkmgqlrdwf pntqdlagnd qenirhadrn
     1801 nsddnhlase dtsakqsgkp giyedrdplr vsisreqsff gsplahdpfs clqlvgqenv
     1861 cgddydeavk lkesvvenha vlsyaveeeh aylgptvkpd dkaktlsyep lssatvstgs
     1921 llsyentdls ltdpesfseh mddskqestt skeeetniis sivpstqdiy qrqnssdvhk
     1981 sllpavdett cghthfqqmi dkyineanli pektdlqele hifpnlhhql fkplephpdf
     2041 dlsssssgis pdnrdfyqrs dssseshcat glskstvyft alrrtsmhss lntspnqqpd
     2101 tnlahvgahs fateniiggs eqcfeqlqpe yssqeesqha dlpsifsiea rdssqgmknq
     2161 nypseehtei lqnkkkivhf qlsignlssv ysssdeanvf dqlnvqhstp cgsnssecst
     2221 khqlesrkes mgfeelskrg vvtmlqsqgl iednknetcr vldinpqvee tdsrlcvrtv
     2281 emgtsiqapy slttqnekyf ensaetdipk itkklsqlge selfassgsf slqssipvwe
     2341 tetghgimee peltlisttd tsiaemdfan ltleeksene akcffqvsvf lplvsateas
     2401 dypavselsi ekprtastet prrltpvpgs lqeafikrkk sfmershqrq keirnkihvs
     2461 ensqiktvke kpsisssvsr lkgvnkvras fpedrkttqa lrhqrglrly nqlaevkqqk
     2521 eektkqeaya qnrarakefh kktleklrak ntc
//
LOCUS       XP_054226322            2412 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 295 kDa isoform X15 [Homo sapiens].
ACCESSION   XP_054226322
VERSION     XP_054226322.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370347.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2412
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2412
                     /product="centrosomal protein of 295 kDa isoform X15"
                     /calculated_mol_wt=272403
     Region          2259..2370
                     /region_name="ALMS_motif"
                     /note="ALMS motif; pfam15309"
                     /db_xref="CDD:464634"
     CDS             1..2412
                     /gene="CEP295"
                     /gene_synonym="KIAA1731; SCKL11"
                     /coded_by="XM_054370347.1:197..7435"
                     /db_xref="GeneID:85459"
                     /db_xref="HGNC:HGNC:29366"
                     /db_xref="MIM:617728"
ORIGIN      
        1 merfekahvr gfqamkkihl aqnqeklmke lkqlqqedla rrrqtvaqmp pqlvelpykr
       61 semkedwqre lefafedmyn adrkvkgnli lhlepeplpt vtnqiqdeel dlsmeqenlg
      121 aaedlpvtea eicssetdvp lvmktqqips kvlfkkllnk irsqkslwti ksmsedesem
      181 ittvseiesk aptvesgtia skertlssgq eqvvesdtlt iesgplased kplscgtnsg
      241 keqeinetlp ittvaqssvl lhpqeeaari rmsarqkqim eieeqkqkql elleqieqqk
      301 lrletdcfra qleeekrkkt qptgvgcrks hhyinhlvgi apascpvisd edshrqmirn
      361 yqhqllqqnr lhrqsvetar kqlleyqtml kgrcpsvsap slitdsvisv pswkserpta
      421 isehwdqgqr lklspnkyqp iqpiqtskle qdhfqvarqn hfpqrqvett etlrasdilt
      481 nqalesqehl rqfsqtetqq rdyklvpkds etlsralshd rqlisqdark isetfgattf
      541 qslesqqlfs ensenisyhl tepssfvplv pqhsfsslpv kvesgkiqep fsamskstvs
      601 tshsiisqmh drpllpseni taqqgnmkal qeqldlqkkv lqatqeaqeq lllckqkeve
      661 qqtglsvflp lvtpdssall psakadlgri qessptknni avssdhhvis qlqdkrlsls
      721 qpilsqqnnf kflqeqlniq kdslqarrea qevlyvhkqs eldrrvcseq aepsfpfqva
      781 qhtftslpsa dtksgkiqeq hssksekglv scqsdipisq dgslsflqqf lplhdslkll
      841 qeqltkqrdt lqarheaqve lllhrqrdlg dsksglvsss sspvvvqhsv asqasakaep
      901 rriqelylse kenvgpschl iiptfqdksl sfpqhslaqq enltilqeqs qiqrvilgak
      961 egtqefvhte selekrisse qtgtssslsq vdeserfqec isiksdstip lshpkiprcq
     1021 erllrvsqhm lplqdnleeh qawldtekea fhfsqktqen tsseqtgsss fipqlvqlsf
     1081 tslasaesgt ileplftese skifsshlqi pqlqdrllri sqliqpqqdn lkalqeqlat
     1141 qreaiilarq eareelllhq sewegrispe qvdtsslplv pqhsfaslpl nesernqepc
     1201 sinsdnivss ghseiptlpd gllglshlvl pqqdnliale ehlhaqtdfl psiektqkel
     1261 vlskpckfee kvssehfiqs hhgdlqalqq qldtqkkair siqevqeell lqrlselekr
     1321 vsseqvcsss fvsqvpvads ertqksfptk sndtlpsshr eiprlqdrll slskpilpqq
     1381 dnmtaqldaq revmysyekp qeelslnkqr klnksesaeh tipslflpke tehsfiplpf
     1441 aeakpkstce lyssqnehaa ppsnpvipgf qdrllsfsqs vltqqdnlgl qkqldlqrev
     1501 lhysqkaqek llvqrqtalq qqiqkheetl kdffkdsqis kptvendlkt qkmgqlrdwf
     1561 pntqdlagnd qenirhadrn nsddnhlase dtsakqsgeh lekdlgrrss kppvakvkcg
     1621 ldlnqhelsa iqevespaig rtsilgkpgi yedrdplrvs isreqsffgs plahdpfscl
     1681 qlvgqenvcg ddydeavklk esvvenhavl syaveeehay lgptvkpddk aktlsyepls
     1741 satvstgsll syentdlslt dpesfsehmd dskqesttsk eeetniissi vpstqdiyqr
     1801 qnssdvhksl lpavdettcg hthfqqmidk yineanlipe ktdlqelehi fpnlhhqlfk
     1861 plephpdfdl sssssgispd nrdfyqrsds sseshcatgl skstvyftal rrtsmhssln
     1921 tspnqqpdtn lahvgahsfa teniiggseq cfeqlqpeys sqeesqhadl psifsieard
     1981 ssqgmknqny pseehteilq nkkkivhfql signlssvys ssdeanvfdq lnvqhstpcg
     2041 snssecstkh qlesrkesmg feelskrgvv tmlqsqglie dnknetcrvl dinpqveetd
     2101 srlcvrtvem gtsiqapysl ttqnekyfen saetdipkit kklsqlgese lfassgsfsl
     2161 qssipvwete tghgimeepe ltlisttdts iaemdfanlt leekseneak cffqvsvflp
     2221 lvsateasdy pavselsiek prtastaetp rrltpvpgsl qeafikrkks fmershqrqk
     2281 eirnkihvse nsqiktvkek psisssvsrl kgvnkvrasf pedrkttqal rhqrglrlyn
     2341 qlaevkqqke ektkqeayaq nrarakefhk vsitegegln fssmkyttet qifipstent
     2401 retssqkyml tf
//
LOCUS       XP_054226323            2412 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 295 kDa isoform X15 [Homo sapiens].
ACCESSION   XP_054226323
VERSION     XP_054226323.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370348.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2412
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2412
                     /product="centrosomal protein of 295 kDa isoform X15"
                     /calculated_mol_wt=272403
     Region          2259..2370
                     /region_name="ALMS_motif"
                     /note="ALMS motif; pfam15309"
                     /db_xref="CDD:464634"
     CDS             1..2412
                     /gene="CEP295"
                     /gene_synonym="KIAA1731; SCKL11"
                     /coded_by="XM_054370348.1:193..7431"
                     /db_xref="GeneID:85459"
                     /db_xref="HGNC:HGNC:29366"
                     /db_xref="MIM:617728"
ORIGIN      
        1 merfekahvr gfqamkkihl aqnqeklmke lkqlqqedla rrrqtvaqmp pqlvelpykr
       61 semkedwqre lefafedmyn adrkvkgnli lhlepeplpt vtnqiqdeel dlsmeqenlg
      121 aaedlpvtea eicssetdvp lvmktqqips kvlfkkllnk irsqkslwti ksmsedesem
      181 ittvseiesk aptvesgtia skertlssgq eqvvesdtlt iesgplased kplscgtnsg
      241 keqeinetlp ittvaqssvl lhpqeeaari rmsarqkqim eieeqkqkql elleqieqqk
      301 lrletdcfra qleeekrkkt qptgvgcrks hhyinhlvgi apascpvisd edshrqmirn
      361 yqhqllqqnr lhrqsvetar kqlleyqtml kgrcpsvsap slitdsvisv pswkserpta
      421 isehwdqgqr lklspnkyqp iqpiqtskle qdhfqvarqn hfpqrqvett etlrasdilt
      481 nqalesqehl rqfsqtetqq rdyklvpkds etlsralshd rqlisqdark isetfgattf
      541 qslesqqlfs ensenisyhl tepssfvplv pqhsfsslpv kvesgkiqep fsamskstvs
      601 tshsiisqmh drpllpseni taqqgnmkal qeqldlqkkv lqatqeaqeq lllckqkeve
      661 qqtglsvflp lvtpdssall psakadlgri qessptknni avssdhhvis qlqdkrlsls
      721 qpilsqqnnf kflqeqlniq kdslqarrea qevlyvhkqs eldrrvcseq aepsfpfqva
      781 qhtftslpsa dtksgkiqeq hssksekglv scqsdipisq dgslsflqqf lplhdslkll
      841 qeqltkqrdt lqarheaqve lllhrqrdlg dsksglvsss sspvvvqhsv asqasakaep
      901 rriqelylse kenvgpschl iiptfqdksl sfpqhslaqq enltilqeqs qiqrvilgak
      961 egtqefvhte selekrisse qtgtssslsq vdeserfqec isiksdstip lshpkiprcq
     1021 erllrvsqhm lplqdnleeh qawldtekea fhfsqktqen tsseqtgsss fipqlvqlsf
     1081 tslasaesgt ileplftese skifsshlqi pqlqdrllri sqliqpqqdn lkalqeqlat
     1141 qreaiilarq eareelllhq sewegrispe qvdtsslplv pqhsfaslpl nesernqepc
     1201 sinsdnivss ghseiptlpd gllglshlvl pqqdnliale ehlhaqtdfl psiektqkel
     1261 vlskpckfee kvssehfiqs hhgdlqalqq qldtqkkair siqevqeell lqrlselekr
     1321 vsseqvcsss fvsqvpvads ertqksfptk sndtlpsshr eiprlqdrll slskpilpqq
     1381 dnmtaqldaq revmysyekp qeelslnkqr klnksesaeh tipslflpke tehsfiplpf
     1441 aeakpkstce lyssqnehaa ppsnpvipgf qdrllsfsqs vltqqdnlgl qkqldlqrev
     1501 lhysqkaqek llvqrqtalq qqiqkheetl kdffkdsqis kptvendlkt qkmgqlrdwf
     1561 pntqdlagnd qenirhadrn nsddnhlase dtsakqsgeh lekdlgrrss kppvakvkcg
     1621 ldlnqhelsa iqevespaig rtsilgkpgi yedrdplrvs isreqsffgs plahdpfscl
     1681 qlvgqenvcg ddydeavklk esvvenhavl syaveeehay lgptvkpddk aktlsyepls
     1741 satvstgsll syentdlslt dpesfsehmd dskqesttsk eeetniissi vpstqdiyqr
     1801 qnssdvhksl lpavdettcg hthfqqmidk yineanlipe ktdlqelehi fpnlhhqlfk
     1861 plephpdfdl sssssgispd nrdfyqrsds sseshcatgl skstvyftal rrtsmhssln
     1921 tspnqqpdtn lahvgahsfa teniiggseq cfeqlqpeys sqeesqhadl psifsieard
     1981 ssqgmknqny pseehteilq nkkkivhfql signlssvys ssdeanvfdq lnvqhstpcg
     2041 snssecstkh qlesrkesmg feelskrgvv tmlqsqglie dnknetcrvl dinpqveetd
     2101 srlcvrtvem gtsiqapysl ttqnekyfen saetdipkit kklsqlgese lfassgsfsl
     2161 qssipvwete tghgimeepe ltlisttdts iaemdfanlt leekseneak cffqvsvflp
     2221 lvsateasdy pavselsiek prtastaetp rrltpvpgsl qeafikrkks fmershqrqk
     2281 eirnkihvse nsqiktvkek psisssvsrl kgvnkvrasf pedrkttqal rhqrglrlyn
     2341 qlaevkqqke ektkqeayaq nrarakefhk vsitegegln fssmkyttet qifipstent
     2401 retssqkyml tf
//
LOCUS       XP_054226324            2133 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 295 kDa isoform X16 [Homo sapiens].
ACCESSION   XP_054226324
VERSION     XP_054226324.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370349.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2133
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2133
                     /product="centrosomal protein of 295 kDa isoform X16"
                     /calculated_mol_wt=240730
     Region          1980..2091
                     /region_name="ALMS_motif"
                     /note="ALMS motif; pfam15309"
                     /db_xref="CDD:464634"
     CDS             1..2133
                     /gene="CEP295"
                     /gene_synonym="KIAA1731; SCKL11"
                     /coded_by="XM_054370349.1:106..6507"
                     /db_xref="GeneID:85459"
                     /db_xref="HGNC:HGNC:29366"
                     /db_xref="MIM:617728"
ORIGIN      
        1 meieeqkqkq lelleqieqq klrletdcfr aqleeekrkk tqptgvgcrk shhyinhlvg
       61 iapascpvis dedshrqmir nyqhqllqqn rlhrqsveta rkqlleyqtm lkgrcpsvsa
      121 pslitdsvis vpswkserpt aisehwdqgq rlklspnkyq piqpiqtskl eqdhfqvarq
      181 nhfpqrqvet tetlrasdil tnqalesqeh lrqfsqtetq qrdyklvpkd setlsralsh
      241 drqlisqdar kisetfgatt fqslesqqlf sensenisyh ltepssfvpl vpqhsfsslp
      301 vkvesgkiqe pfsamskstv stshsiisqm hdrpllpsen itaqqgnmka lqeqldlqkk
      361 vlqatqeaqe qlllckqkev eqqtglsvfl plvtpdssal lpsakadlgr iqessptknn
      421 iavssdhhvi sqlqdkrlsl sqpilsqqnn fkflqeqlni qkdslqarre aqevlyvhkq
      481 seldrrvcse qaepsfpfqv aqhtftslps adtksgkiqe qhssksekgl vscqsdipis
      541 qdgslsflqq flplhdslkl lqeqltkqrd tlqarheaqv elllhrqrdl gdsksglvss
      601 ssspvvvqhs vasqasakae prriqelyls ekenvgpsch liiptfqdks lsfpqhslaq
      661 qenltilqeq sqiqrvilga kegtqefvht eselekriss eqtgtsssls qvdeserfqe
      721 cisiksdsti plshpkiprc qerllrvsqh mlplqdnlee hqawldteke afhfsqktqe
      781 ntsseqtgss sfipqlvqls ftslasaesg tileplftes eskifsshlq ipqlqdrllr
      841 isqliqpqqd nlkalqeqla tqreaiilar qeareelllh qsewegrisp eqvdtsslpl
      901 vpqhsfaslp lnesernqep csinsdnivs sghseiptlp dgllglshlv lpqqdnlial
      961 eehlhaqtdf lpsiektqke lvlskpckfe ekvssehfiq shhgdlqalq qqldtqkkai
     1021 rsiqevqeel llqrlselek rvsseqvcss sfvsqvpvad sertqksfpt ksndtlpssh
     1081 reiprlqdrl lslskpilpq qdnmtaqlda qrevmysyek pqeelslnkq rklnksesae
     1141 htipslflpk etehsfiplp faeakpkstc elyssqneha appsnpvipg fqdrllsfsq
     1201 svltqqdnlg lqkqldlqre vlhysqkaqe kllvqrqtal qqqiqkheet lkdffkdsqi
     1261 skptvendlk tqkmgqlrdw fpntqdlagn dqenirhadr nnsddnhlas edtsakqsge
     1321 hlekdlgrrs skppvakvkc gldlnqhels aiqevespai grtsilgkpg iyedrdplrv
     1381 sisreqsffg splahdpfsc lqlvgqenvc gddydeavkl kesvvenhav lsyaveeeha
     1441 ylgptvkpdd kaktlsyepl ssatvstgsl lsyentdlsl tdpesfsehm ddskqestts
     1501 keeetniiss ivpstqdiyq rqnssdvhks llpavdettc ghthfqqmid kyineanlip
     1561 ektdlqeleh ifpnlhhqlf kplephpdfd lsssssgisp dnrdfyqrsd ssseshcatg
     1621 lskstvyfta lrrtsmhssl ntspnqqpdt nlahvgahsf ateniiggse qcfeqlqpey
     1681 ssqeesqhad lpsifsiear dssqgmknqn ypseehteil qnkkkivhfq lsignlssvy
     1741 sssdeanvfd qlnvqhstpc gsnssecstk hqlesrkesm gfeelskrgv vtmlqsqgli
     1801 ednknetcrv ldinpqveet dsrlcvrtve mgtsiqapys lttqnekyfe nsaetdipki
     1861 tkklsqlges elfassgsfs lqssipvwet etghgimeep eltlisttdt siaemdfanl
     1921 tleeksenea kcffqvsvfl plvsateasd ypavselsie kprtastaet prrltpvpgs
     1981 lqeafikrkk sfmershqrq keirnkihvs ensqiktvke kpsisssvsr lkgvnkvras
     2041 fpedrkttqa lrhqrglrly nqlaevkqqk eektkqeaya qnrarakefh kvsitegegl
     2101 nfssmkytte tqifipsten tretssqkym ltf
//
LOCUS       XP_054226325            2133 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 295 kDa isoform X16 [Homo sapiens].
ACCESSION   XP_054226325
VERSION     XP_054226325.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370350.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2133
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2133
                     /product="centrosomal protein of 295 kDa isoform X16"
                     /calculated_mol_wt=240730
     Region          1980..2091
                     /region_name="ALMS_motif"
                     /note="ALMS motif; pfam15309"
                     /db_xref="CDD:464634"
     CDS             1..2133
                     /gene="CEP295"
                     /gene_synonym="KIAA1731; SCKL11"
                     /coded_by="XM_054370350.1:71..6472"
                     /db_xref="GeneID:85459"
                     /db_xref="HGNC:HGNC:29366"
                     /db_xref="MIM:617728"
ORIGIN      
        1 meieeqkqkq lelleqieqq klrletdcfr aqleeekrkk tqptgvgcrk shhyinhlvg
       61 iapascpvis dedshrqmir nyqhqllqqn rlhrqsveta rkqlleyqtm lkgrcpsvsa
      121 pslitdsvis vpswkserpt aisehwdqgq rlklspnkyq piqpiqtskl eqdhfqvarq
      181 nhfpqrqvet tetlrasdil tnqalesqeh lrqfsqtetq qrdyklvpkd setlsralsh
      241 drqlisqdar kisetfgatt fqslesqqlf sensenisyh ltepssfvpl vpqhsfsslp
      301 vkvesgkiqe pfsamskstv stshsiisqm hdrpllpsen itaqqgnmka lqeqldlqkk
      361 vlqatqeaqe qlllckqkev eqqtglsvfl plvtpdssal lpsakadlgr iqessptknn
      421 iavssdhhvi sqlqdkrlsl sqpilsqqnn fkflqeqlni qkdslqarre aqevlyvhkq
      481 seldrrvcse qaepsfpfqv aqhtftslps adtksgkiqe qhssksekgl vscqsdipis
      541 qdgslsflqq flplhdslkl lqeqltkqrd tlqarheaqv elllhrqrdl gdsksglvss
      601 ssspvvvqhs vasqasakae prriqelyls ekenvgpsch liiptfqdks lsfpqhslaq
      661 qenltilqeq sqiqrvilga kegtqefvht eselekriss eqtgtsssls qvdeserfqe
      721 cisiksdsti plshpkiprc qerllrvsqh mlplqdnlee hqawldteke afhfsqktqe
      781 ntsseqtgss sfipqlvqls ftslasaesg tileplftes eskifsshlq ipqlqdrllr
      841 isqliqpqqd nlkalqeqla tqreaiilar qeareelllh qsewegrisp eqvdtsslpl
      901 vpqhsfaslp lnesernqep csinsdnivs sghseiptlp dgllglshlv lpqqdnlial
      961 eehlhaqtdf lpsiektqke lvlskpckfe ekvssehfiq shhgdlqalq qqldtqkkai
     1021 rsiqevqeel llqrlselek rvsseqvcss sfvsqvpvad sertqksfpt ksndtlpssh
     1081 reiprlqdrl lslskpilpq qdnmtaqlda qrevmysyek pqeelslnkq rklnksesae
     1141 htipslflpk etehsfiplp faeakpkstc elyssqneha appsnpvipg fqdrllsfsq
     1201 svltqqdnlg lqkqldlqre vlhysqkaqe kllvqrqtal qqqiqkheet lkdffkdsqi
     1261 skptvendlk tqkmgqlrdw fpntqdlagn dqenirhadr nnsddnhlas edtsakqsge
     1321 hlekdlgrrs skppvakvkc gldlnqhels aiqevespai grtsilgkpg iyedrdplrv
     1381 sisreqsffg splahdpfsc lqlvgqenvc gddydeavkl kesvvenhav lsyaveeeha
     1441 ylgptvkpdd kaktlsyepl ssatvstgsl lsyentdlsl tdpesfsehm ddskqestts
     1501 keeetniiss ivpstqdiyq rqnssdvhks llpavdettc ghthfqqmid kyineanlip
     1561 ektdlqeleh ifpnlhhqlf kplephpdfd lsssssgisp dnrdfyqrsd ssseshcatg
     1621 lskstvyfta lrrtsmhssl ntspnqqpdt nlahvgahsf ateniiggse qcfeqlqpey
     1681 ssqeesqhad lpsifsiear dssqgmknqn ypseehteil qnkkkivhfq lsignlssvy
     1741 sssdeanvfd qlnvqhstpc gsnssecstk hqlesrkesm gfeelskrgv vtmlqsqgli
     1801 ednknetcrv ldinpqveet dsrlcvrtve mgtsiqapys lttqnekyfe nsaetdipki
     1861 tkklsqlges elfassgsfs lqssipvwet etghgimeep eltlisttdt siaemdfanl
     1921 tleeksenea kcffqvsvfl plvsateasd ypavselsie kprtastaet prrltpvpgs
     1981 lqeafikrkk sfmershqrq keirnkihvs ensqiktvke kpsisssvsr lkgvnkvras
     2041 fpedrkttqa lrhqrglrly nqlaevkqqk eektkqeaya qnrarakefh kvsitegegl
     2101 nfssmkytte tqifipsten tretssqkym ltf
//
LOCUS       XP_054226326            1987 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 295 kDa isoform X17 [Homo sapiens].
ACCESSION   XP_054226326
VERSION     XP_054226326.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370351.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1987
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1987
                     /product="centrosomal protein of 295 kDa isoform X17"
                     /calculated_mol_wt=226294
     Region          <27..554
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     CDS             1..1987
                     /gene="CEP295"
                     /gene_synonym="KIAA1731; SCKL11"
                     /coded_by="XM_054370351.1:120..6083"
                     /db_xref="GeneID:85459"
                     /db_xref="HGNC:HGNC:29366"
                     /db_xref="MIM:617728"
ORIGIN      
        1 mkrkvvnthk lrlspneeaf ilkedyerrr klrllqvreq erdialqire dikqrrnqqf
       61 trlaeelrae weesqtqkiq nleklylasl rsmgeghrqa kenepdldal aqraaerkrk
      121 adlrhkealk vqknqkeill kqktwhikar keallveker sakitslppp pptlfeniev
      181 krisavktns styhhlhtfv nretdtkqpd arlaaeeeak rleelqkqaa qermerfeka
      241 hvrgfqamkk ihlaqnqekl mkelkqlqqe dlarrrqtva qmppqlvelp ykrsemkedw
      301 qrelefafed mynadrkvkg nlilhlepep lptvtnqiqd eeldlsmeqe nlgaaedlpv
      361 teaeicsset dvplvmktqq ipskvlfkkl lnkirsqksl wtiksmsede semittvsei
      421 eskaptvesg tiaskertls sgqeqvvesd tltiesgpla sedkplscgt nsgkeqeine
      481 tlpittvaqs svllhpqeea arirmsarqk qimeieeqkq kqlelleqie qqklrletdc
      541 fraqleeekr kktqptgvgc rkshhyinhl vgiapascpv isdedshrqm irnyqhqllq
      601 qnrlhrqsve tarkqlleyq tmlkgrcpsv sapslitdsv isvpswkser ptaisehwdq
      661 gqrlklspnk yqpiqpiqts kleqdhfqva rqnhfpqrqv ettetlrasd iltnqalesq
      721 ehlrqfsqte tqqrdyklvp kdsetlsral shdrqlisqd arkisetfga ttfqslesqq
      781 lfsensenis yhltepssfv plvpqhsfss lpvkvesgki qepfsamsks tvstshsiis
      841 qmhdrpllps enitaqqgnm kalqeqldlq kkvlqatqea qeqlllckqk eveqqtglsv
      901 flplvtpdss allpsakadl griqessptk nniavssdhh visqlqdkrl slsqpilsqq
      961 nnfkflqeql niqkdslqar reaqevlyvh kqseldrrvc seqaepsfpf qvaqhtftsl
     1021 psadtksgki qeqhssksek glvscqsdip isqdgslsfl qqflplhdsl kllqeqltkq
     1081 rdtlqarhea qvelllhrqr dlgdsksglv ssssspvvvq hsvasqasak aeprriqely
     1141 lsekenvgps chliiptfqd kslsfpqhsl aqqenltilq eqsqiqrvil gakegtqefv
     1201 hteselekri sseqtgtsss lsqvdeserf qecisiksds tiplshpkip rcqerllrvs
     1261 qhmlplqdnl eehqawldte keafhfsqkt qentsseqtg sssfipqlvq lsftslasae
     1321 sgtileplft eseskifssh lqipqlqdrl lrisqliqpq qdnlkalqeq latqreaiil
     1381 arqeareell lhqsewegri speqvdtssl plvpqhsfas lplnesernq epcsinsdni
     1441 vssghseipt lpdgllglsh lvlpqqdnli aleehlhaqt dflpsiektq kelvlskpck
     1501 feekvssehf iqshhgdlqa lqqqldtqkk airsiqevqe elllqrlsel ekrvsseqvc
     1561 sssfvsqvpv adsertqksf ptksndtlps shreiprlqd rllslskpil pqqdnmtaql
     1621 daqrevmysy ekpqeelsln kqrklnkses aehtipslfl pketehsfip lpfaeakpks
     1681 tcelyssqne haappsnpvi pgfqdrllsf sqsvltqqdn lglqkqldlq revlhysqka
     1741 qekllvqrqt alqqqiqkhe etlkdffkds qiskptvend lktqkmgqlr dwfpntqdla
     1801 gndqenirha drnnsddnhl asedtsakqs gehlekdlgr rsskppvakv kcgldlnqhe
     1861 lsaiqevesp aigrtsilgk pgiyedrdpl rvsisreqsf fgsplahdpf sclqlvgqen
     1921 vcgddydeav klkesvvenh avlsyaveee haylgptvkp ddkshfqstw miasknlppv
     1981 kkrkqil
//
LOCUS       XP_054226327            1939 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 295 kDa isoform X18 [Homo sapiens].
ACCESSION   XP_054226327
VERSION     XP_054226327.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370352.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1939
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1939
                     /product="centrosomal protein of 295 kDa isoform X18"
                     /calculated_mol_wt=221105
     Region          <27..554
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     CDS             1..1939
                     /gene="CEP295"
                     /gene_synonym="KIAA1731; SCKL11"
                     /coded_by="XM_054370352.1:120..5939"
                     /db_xref="GeneID:85459"
                     /db_xref="HGNC:HGNC:29366"
                     /db_xref="MIM:617728"
ORIGIN      
        1 mkrkvvnthk lrlspneeaf ilkedyerrr klrllqvreq erdialqire dikqrrnqqf
       61 trlaeelrae weesqtqkiq nleklylasl rsmgeghrqa kenepdldal aqraaerkrk
      121 adlrhkealk vqknqkeill kqktwhikar keallveker sakitslppp pptlfeniev
      181 krisavktns styhhlhtfv nretdtkqpd arlaaeeeak rleelqkqaa qermerfeka
      241 hvrgfqamkk ihlaqnqekl mkelkqlqqe dlarrrqtva qmppqlvelp ykrsemkedw
      301 qrelefafed mynadrkvkg nlilhlepep lptvtnqiqd eeldlsmeqe nlgaaedlpv
      361 teaeicsset dvplvmktqq ipskvlfkkl lnkirsqksl wtiksmsede semittvsei
      421 eskaptvesg tiaskertls sgqeqvvesd tltiesgpla sedkplscgt nsgkeqeine
      481 tlpittvaqs svllhpqeea arirmsarqk qimeieeqkq kqlelleqie qqklrletdc
      541 fraqleeekr kktqptgvgc rkshhyinhl vgiapascpv isdedshrqm irnyqhqllq
      601 qnrlhrqsve tarkqlleyq tmlkgrcpsv sapslitdsv isvpswkser ptaisehwdq
      661 gqrlklspnk yqpiqpiqts kleqdhfqva rqnhfpqrqv ettetlrasd iltnqalesq
      721 ehlrqfsqte tqqrdyklvp kdsetlsral shdrqlisqd arkisetfga ttfqslesqq
      781 lfsensenis yhltepssfv plvpqhsfss lpvkvesgki qepfsamsks tvstshsiis
      841 qmhdrpllps enitaqqgnm kalqeqldlq kkvlqatqea qeqlllckqk eveqqtglsv
      901 flplvtpdss allpsakadl griqessptk nniavssdhh visqlqdkrl slsqpilsqq
      961 nnfkflqeql niqkdslqar reaqevlyvh kqseldrrvc seqaepsfpf qvaqhtftsl
     1021 psadtksgki qeqhssksek glvscqsdip isqdgslsfl qqflplhdsl kllqeqltkq
     1081 rdtlqarhea qvelllhrqr dlgdsksglv ssssspvvvq hsvasqasak aeprriqely
     1141 lsekenvgps chliiptfqd kslsfpqhsl aqqenltilq eqsqiqrvil gakegtqefv
     1201 hteselekri sseqtgtsss lsqvdeserf qecisiksds tiplshpkip rcqerllrvs
     1261 qhmlplqdnl eehqawldte keafhfsqkt qentsseqtg sssfipqlvq lsftslasae
     1321 sgtileplft eseskifssh lqipqlqdrl lrisqliqpq qdnlkalqeq latqreaiil
     1381 arqeareell lhqsewegri speqvdtssl plvpqhsfas lplnesernq epcsinsdni
     1441 vssghseipt lpdgllglsh lvlpqqdnli aleehlhaqt dflpsiektq kelvlskpck
     1501 feekvssehf iqshhgdlqa lqqqldtqkk airsiqevqe elllqrlsel ekrvsseqvc
     1561 sssfvsqvpv adsertqksf ptksndtlps shreiprlqd rllslskpil pqqdnmtaql
     1621 daqrevmysy ekpqeelsln kqrklnkses aehtipslfl pketehsfip lpfaeakpks
     1681 tcelyssqne haappsnpvi pgfqdrllsf sqsvltqqdn lglqkqldlq revlhysqka
     1741 qekllvqrqt alqqqiqkhe etlkdffkds qiskptvend lktqkmgqlr dwfpntqdla
     1801 gndqenirha drnnsddnhl asedtsakqs gkpgiyedrd plrvsisreq sffgsplahd
     1861 pfsclqlvgq envcgddyde avklkesvve nhavlsyave eehaylgptv kpddkshfqs
     1921 twmiasknlp pvkkrkqil
//
LOCUS       XP_054226331             424 aa            linear   PRI 05-AUG-2025
DEFINITION  cathepsin F isoform X1 [Homo sapiens].
ACCESSION   XP_054226331
VERSION     XP_054226331.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370356.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..424
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..424
                     /product="cathepsin F isoform X1"
                     /calculated_mol_wt=46948
     Region          127..183
                     /region_name="Inhibitor_I29"
                     /note="Cathepsin propeptide inhibitor domain (I29);
                     smart00848"
                     /db_xref="CDD:214853"
     Region          211..422
                     /region_name="Peptidase_C1"
                     /note="Papain family cysteine protease; pfam00112"
                     /db_xref="CDD:425470"
     Site            order(229,235,371,391)
                     /site_type="active"
                     /db_xref="CDD:239068"
     Site            order(277..278,343,369,372,417)
                     /site_type="active"
                     /note="S2 subsite [active]"
                     /db_xref="CDD:239068"
     CDS             1..424
                     /gene="CTSF"
                     /gene_synonym="CATSF; CLN13"
                     /coded_by="XM_054370356.1:381..1655"
                     /db_xref="GeneID:8722"
                     /db_xref="HGNC:HGNC:2531"
                     /db_xref="MIM:603539"
ORIGIN      
        1 mgparwtnrs lagqgslysl eatleeppcn dpmvcrlpvs kktllcsfqv ldelgrhvll
       61 rkdcgpvdtk vpgagepksa ftqgsamiss lsqnhpdnrn etfssvisll nedplsqdlp
      121 vkmasifknf vitynrtyes keearwrlsv fvnnmvraqk iqaldrgtaq ygvtkfsdlt
      181 eeefrtiyln tllrkepgnk mkqaksvgdl appewdwrsk gavtkvkdqg mcgscwafsv
      241 tgnvegqwfl nqgtllslse qelldcdkmd kacmgglpsn aysaiknlgg leteddysyq
      301 ghmqscnfsa ekakvyinds velsqneqkl aawlakrgpi svainafgmq fyrhgisrpl
      361 rplcspwlid havllvgygn rsdvpfwaik nswgtdwgek gyyylhrgsg acgvntmass
      421 avvd
//
LOCUS       XP_054226333             415 aa            linear   PRI 05-AUG-2025
DEFINITION  polycomb protein EED isoform X2 [Homo sapiens].
ACCESSION   XP_054226333
VERSION     XP_054226333.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370358.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..415
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..415
                     /product="polycomb protein EED isoform X2"
                     /calculated_mol_wt=47335
     Region          <83..269
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          96..140
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          148..188
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          193..230
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          240..302
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          309..382
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..415
                     /gene="EED"
                     /gene_synonym="COGIS; HEED; WAIT1"
                     /coded_by="XM_054370358.1:478..1725"
                     /db_xref="GeneID:8726"
                     /db_xref="HGNC:HGNC:3188"
                     /db_xref="MIM:605984"
ORIGIN      
        1 mserevstap agtdmpaakk qklssdensn pdlsgdendd avsiesgtnt erpdtptntp
       61 napgrkswgk gkwkskkcky sfkcvnslke dhnqplfgvq fnwhskegdp lvfatvgsnr
      121 vtlyechsqg eirllqsyvd adadenfytc awtydsntsh pllavagsrg iiriinpitm
      181 qcikhyvghg nainelkfhp rdpnlllsvs kdhalrlwni qtdtlvaifg gveghrdevl
      241 sadydllgek imscgmdhsl klwrinskrm mnaikesydy npnktnrpfi sqkihfpdfs
      301 trdihrnyvd cvrwlgdlil sksgrailhs hqqcmrdpvs pnlrqhlsce naivcwkpgk
      361 meddidkikp sesnvtilgr fdysqcdiwy mrfsmdfwqk eyktqrnsqe hrgwn
//
LOCUS       XP_054226334             403 aa            linear   PRI 05-AUG-2025
DEFINITION  polycomb protein EED isoform X3 [Homo sapiens].
ACCESSION   XP_054226334
VERSION     XP_054226334.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370359.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..403
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..403
                     /product="polycomb protein EED isoform X3"
                     /calculated_mol_wt=45788
     Region          96..140
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          148..188
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          150..398
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          193..230
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          240..302
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          309..357
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          365..391
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..403
                     /gene="EED"
                     /gene_synonym="COGIS; HEED; WAIT1"
                     /coded_by="XM_054370359.1:478..1689"
                     /db_xref="GeneID:8726"
                     /db_xref="HGNC:HGNC:3188"
                     /db_xref="MIM:605984"
ORIGIN      
        1 mserevstap agtdmpaakk qklssdensn pdlsgdendd avsiesgtnt erpdtptntp
       61 napgrkswgk gkwkskkcky sfkcvnslke dhnqplfgvq fnwhskegdp lvfatvgsnr
      121 vtlyechsqg eirllqsyvd adadenfytc awtydsntsh pllavagsrg iiriinpitm
      181 qcikhyvghg nainelkfhp rdpnlllsvs kdhalrlwni qtdtlvaifg gveghrdevl
      241 sadydllgek imscgmdhsl klwrinskrm mnaikesydy npnktnrpfi sqkihfpdfs
      301 trdihrnyvd cvrwlgdlil skscenaivc wkpgkmeddi dkikpsesnv tilgrfdysq
      361 cdiwymrfsm dfwqkmlalg nqvgklyvwd levedphkan rdh
//
LOCUS       XP_054226338             287 aa            linear   PRI 05-AUG-2025
DEFINITION  polycomb protein EED isoform X7 [Homo sapiens].
ACCESSION   XP_054226338
VERSION     XP_054226338.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370363.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..287
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..287
                     /product="polycomb protein EED isoform X7"
                     /calculated_mol_wt=33219
     Region          3..284
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Site            order(10,29,33,39..40,55..56,74,78,84..85,112,118..119,
                     126,141,151..152,169,171,177,185,204..205,224,229,
                     235..236,252..253,273,277,283..284)
                     /site_type="active"
                     /note="structural tetrad [active]"
                     /db_xref="CDD:238121"
     Region          14..51
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          61..123
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          130..203
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          211..251
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          259..283
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..287
                     /gene="EED"
                     /gene_synonym="COGIS; HEED; WAIT1"
                     /coded_by="XM_054370363.1:536..1399"
                     /db_xref="GeneID:8726"
                     /db_xref="HGNC:HGNC:3188"
                     /db_xref="MIM:605984"
ORIGIN      
        1 mqcikhyvgh gnainelkfh prdpnlllsv skdhalrlwn iqtdtlvaif ggveghrdev
       61 lsadydllge kimscgmdhs lklwrinskr mmnaikesyd ynpnktnrpf isqkihfpdf
      121 strdihrnyv dcvrwlgdli lsksgrailh shqqcmrdpv spnlrqhlsc enaivcwkpg
      181 kmeddidkik psesnvtilg rfdysqcdiw ymrfsmdfwq kmlalgnqvg klyvwdleve
      241 dphkakcttl thhkcgaair qtsfsrdssi liavcddasi wrwdrlr
//
LOCUS       XP_054226340             280 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc finger protein ZPR1 isoform X1 [Homo sapiens].
ACCESSION   XP_054226340
VERSION     XP_054226340.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370365.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..280
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..280
                     /product="zinc finger protein ZPR1 isoform X1"
                     /calculated_mol_wt=30832
     Region          49..206
                     /region_name="zf-ZPR1"
                     /note="ZPR1 zinc-finger domain; pfam03367"
                     /db_xref="CDD:427263"
     CDS             1..280
                     /gene="ZPR1"
                     /gene_synonym="GKAF; ZNF259"
                     /coded_by="XM_054370365.1:34..876"
                     /db_xref="GeneID:8882"
                     /db_xref="HGNC:HGNC:13051"
                     /db_xref="MIM:603901"
ORIGIN      
        1 maasgavepg ppgaavapsp apapppapdh lfrpisaede eqqpteiesl cmncycngmt
       61 rllltkipff reiivssfsc ehcgwnntei qsagriqdqg vrytlsvral edmnrevvkt
      121 dsaatripel dfeipafsqk galttvegli traisgleqd qparrankda taeridefiv
      181 klkelkqvas pftliiddps gnsfvenpha pqkddalvit hynrtrqqee mlglqeeapa
      241 ekpeeedlrn evlqfstncp ecnapaqtnm klmvvlfawk
//
LOCUS       XP_054226342             571 aa            linear   PRI 05-AUG-2025
DEFINITION  phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2 isoform
            X2 [Homo sapiens].
ACCESSION   XP_054226342
VERSION     XP_054226342.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370367.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..571
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..571
                     /product="phosphatidylinositol-3,5-bisphosphate
                     3-phosphatase MTMR2 isoform X2"
                     /calculated_mol_wt=65828
     Region          1..115
                     /region_name="PH-like"
                     /note="Pleckstrin homology-like domain; cl17171"
                     /db_xref="CDD:473070"
     Region          130..456
                     /region_name="Myotub-related"
                     /note="Myotubularin-like phosphatase domain; pfam06602"
                     /db_xref="CDD:461958"
     CDS             1..571
                     /gene="MTMR2"
                     /gene_synonym="CMT4B; CMT4B1"
                     /coded_by="XM_054370367.1:313..2028"
                     /db_xref="GeneID:8898"
                     /db_xref="HGNC:HGNC:7450"
                     /db_xref="MIM:603557"
ORIGIN      
        1 meeppllpge nikdmakdvt yicpftgavr gtltvtnyrl yfksmerdpp fvldaslgvi
       61 nrvekiggas srgensygle tvckdirnlr fahkpegrtr rsifenlmky afpvsnnlpl
      121 fafeykevfp engwklydpl leyrrqgipn eswritkine ryelcdtypa llvvpanipd
      181 eelkrvasfr srgripvlsw ihpesqatit rcsqpmvgvs gkrskedeky lqaimdsnaq
      241 shkififdar psvnavanka kgggyeseda yqnaelvfld ihnihvmres lrklkeivyp
      301 nieethwlsn lesthwlehi klilagalri adkvesgkts vvvhcsdgwd rtaqltslam
      361 lmldgyyrti rgfevlveke wlsfghrfql rvghgdknha dadrspvflq fidcvwqmtr
      421 qfptafefne yflitildhl ysclfgtflc nseqqrgken lpkrtvslws yinsqledft
      481 nplygsysnh vlypvasmrh lelwvgyyir wnprmkpqep ihnrykella kraelqkkve
      541 elqreisnrs tssserassp aqcvtpvqtv v
//
LOCUS       XP_054226345             453 aa            linear   PRI 05-AUG-2025
DEFINITION  galactose-3-O-sulfotransferase 3 isoform X1 [Homo sapiens].
ACCESSION   XP_054226345
VERSION     XP_054226345.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370370.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..453
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..453
                     /product="galactose-3-O-sulfotransferase 3 isoform X1"
                     /calculated_mol_wt=50765
     Region          68..421
                     /region_name="Sulfotransfer_2"
                     /note="Sulfotransferase family; cl22970"
                     /db_xref="CDD:451469"
     CDS             1..453
                     /gene="GAL3ST3"
                     /gene_synonym="GAL3ST-3; GAL3ST2"
                     /coded_by="XM_054370370.1:131..1492"
                     /db_xref="GeneID:89792"
                     /db_xref="HGNC:HGNC:24144"
                     /db_xref="MIM:608234"
ORIGIN      
        1 mntrraagii egileatkhr prpfhecspg gaalwgipqs lgkgrgqaaa pshpplrtlp
       61 gpgrypklfp lscpplrnsp prpkhmtvaf lkthktagtt vqnilfrfae rhnltvalph
      121 pscehqfcyp rnfsahfvhp atrpphvlas hlrfdraele rlmppstvyv tilrepaamf
      181 eslfsyynqy cpafrrvpna sleaflrape ayyragehfa mfahntlayd lggdnerspr
      241 ddaaylagli rqveevfslv miaeyfdesl vllrrllawd lddvlyakln araassrlaa
      301 ipaalaraar twnaldagly dhfnatfwrh varagracve rearelrear qrllrrcfgd
      361 epllrpaaqi rtkqlqpwqp srkvdimgyd lpgggagpat eaclklampe vqysnyllrk
      421 qkrrggarar pepvldnppp rpirvlprgp qgp
//
LOCUS       XP_054226346            2485 aa            linear   PRI 05-AUG-2025
DEFINITION  neuron navigator 2 isoform X1 [Homo sapiens].
ACCESSION   XP_054226346
VERSION     XP_054226346.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370371.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2485
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2485
                     /product="neuron navigator 2 isoform X1"
                     /calculated_mol_wt=267655
     Region          77..190
                     /region_name="CH_NAV2"
                     /note="calponin homology (CH) domain found in neuron
                     navigator 2; cd21285"
                     /db_xref="CDD:409134"
     Site            order(87,91,145,147..148,151..152,154,163..171,176,
                     178..179,181..182,185..186,189)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409134"
     Region          <309..738
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          969..>1321
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          <1687..>1956
                     /region_name="Mplasa_alph_rch"
                     /note="helix-rich Mycoplasma protein; TIGR04523"
                     /db_xref="CDD:275316"
     Region          1687..>1763
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          <1903..>1958
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          1988..2372
                     /region_name="McrB"
                     /note="5-methylcytosine-specific restriction endonuclease
                     McrBC, GTP-binding regulatory subunit McrB [Defense
                     mechanisms]; COG1401"
                     /db_xref="CDD:441011"
     CDS             1..2485
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /coded_by="XM_054370371.1:860..8317"
                     /db_xref="GeneID:89797"
                     /db_xref="HGNC:HGNC:15997"
                     /db_xref="MIM:607026"
ORIGIN      
        1 mpailvaskm ksglpkpvhs aapilhvppa ragpqpcylk lgskvevskt typsqiplks
       61 qvlqglqepa geglplrksg svengfdtqi ytdwanhyla ksghkrlikd lqqdvtdgvl
      121 laqiiqvvan ekiedingcp knrsqmieni daclnflaak giniqglsae eirngnlkai
      181 lglffslsry kqqqqqpqkq hlssplppav sqvagapsqc qagtpqqqvp vtpqapcqph
      241 qpaphqqska qaemqssass kdssqskiir ftlgqkkisr lpgptarvsa agseaktrgg
      301 sttannrrsq sfnnydkskp vtspppppss hekeplassa sshpgmsdna paslesgsss
      361 tptncstssa ipqpgaatkp wrskslsvkh satvsmlsvk ppgpeaprpt peamkpapnn
      421 qksmleklkl fnskggskag egpgsrdtsc erletlpsfe eseeleaasr mlttvgpass
      481 spkialkgia qrtfsraltn kksslkgnek ekekqqrekd kekskdlakr asvterldlk
      541 eepkedpsga avpempkkss kiasfipkgg klnsakkepm apshsgipkp gmksmpgksp
      601 sapapskege rsrsgklssg lpqqkpqldg rhssssssla ssegkgpggt tlnhsissqt
      661 vsgsvgttqt tgsntvsvql pqpqqqynhp ntatvapfly rsqtdtegnv taessstgvs
      721 vepshftktg qpaleeltge dpearrlrtv kniadlrqnl eetmsslrgt qvthstlett
      781 fdtnvttems grsilsltgr ptplswrlgq ssprlqagda psmgngyppr anasrfinte
      841 sgryvysapl rrqlasrgss vchvdvsdka gdemdlegis mdapgymsdg dvlsknirtd
      901 ditsgymtdg glglytrrln rlpdgmavvr etlqrntslg lgdadswdds ssvssgisdt
      961 idnlstddin tsssissyan tpassrknld vqtdaekhsq vernslwsgd dvkksdggsd
     1021 sgikmepgsk wrrnpsdvsd esdkstsgkk npvisqtgsw rrgmtaqvgi tmprtkasap
     1081 agalktpgtg ktddakvsek grlspkasqv krspsdagrs sgdeskkplp sssrtptana
     1141 nsfgfkkqsg saaglamita sgvtvtsrsa tlgkipkssa lvsrsagrks smdgaqnqdd
     1201 gylalssrtn lqyrslprps ksnsrngagn rsstssidsn issksaglpv pklrepskta
     1261 lgsslpglvn qtdkekgiss dnesvascns vkvnpaaqpv sspaqtslqp gakypdvasp
     1321 tlrrlfggkp tkqvpiatae nmknsvvisn phatmtqqgn ldspsgsgvl ssgsssplys
     1381 knvdlnqspl asspssahsa psnsltwgtn assssavskd glgfqsvssl htscesidis
     1441 lssggvpshn sstgliassk ddsltpfvrt nsvkttlses plsspaaspk fcrstlprkq
     1501 dsdphldrnt lpkkglrytp tsqlrtqeda kewlrshsag glqdtaansp fssgssvtsp
     1561 sgtrfnfsql aspttvtqms lsnptmlrth slsnadgqyd pytdsrfrns smsldeksrt
     1621 msrsgsfrdg feeeswekss vdnfvsrlhs slhfslplfh haryelvhgs slslvsstss
     1681 vystpeekcq seirklrrel dasqekvsal ttqltanahl vaafeqslgn mtirlqsltm
     1741 taeqkdseln elrktiellk kqnaaaqaai ngvintpeln ckgngtaqsa dlrirrqhss
     1801 dsvssinsat shssvgsnie sdskkkkrkn wlrssfkqaf gkkkspksas shsdieemtd
     1861 sslpsspklp hngstgstpl lrnshsnsli secmdseaet vmqlrnelrd kemkltdirl
     1921 ealssahqld qlreamnrmq seieklkaen drlksesqgs gcsrapsqvs isasprqsmg
     1981 lsqhslnlte stsldmlldd tgecsarkeg grhvkivvsf qeemkwkeds rphlfligci
     2041 gvsgktkwdv ldgvvrrlfk eyiihvdpvs qlglnsdsvl gysigeikrs ntsetpellp
     2101 cgylvgentt isvtvkglae nsldslvfes lipkpilqry vslliehrri ilsgpsgtgk
     2161 tylanrlsey ivlregrelt dgviatfnvd hksskelrqy lsnladqcns ennavdmplv
     2221 iildnlhhvs slgeifngll nckyhkcpyi igtmnqatss tpnlqlhhnf rwvlcanhte
     2281 pvkgflgrfl rrklmeteis grvrnmelvk iidwipkvwh hlnrfleahs ssdvtigprl
     2341 flscpidvdg srvwftdlwn ysiipyllea ireglqlygr rapwedpakw vmdtypwaas
     2401 pqqhewppll qlrpedvgfd gysmpregst skqmppsdae gdplmnmlmr lqeaanyssp
     2461 qsydsdsnsn shhddildss lestl
//
LOCUS       XP_054226347            2466 aa            linear   PRI 05-AUG-2025
DEFINITION  neuron navigator 2 isoform X2 [Homo sapiens].
ACCESSION   XP_054226347
VERSION     XP_054226347.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370372.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2466
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2466
                     /product="neuron navigator 2 isoform X2"
                     /calculated_mol_wt=265642
     Region          77..190
                     /region_name="CH_NAV2"
                     /note="calponin homology (CH) domain found in neuron
                     navigator 2; cd21285"
                     /db_xref="CDD:409134"
     Site            order(87,91,145,147..148,151..152,154,163..171,176,
                     178..179,181..182,185..186,189)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409134"
     Region          <309..738
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          969..>1321
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          <1665..>1937
                     /region_name="Mplasa_alph_rch"
                     /note="helix-rich Mycoplasma protein; TIGR04523"
                     /db_xref="CDD:275316"
     Region          1665..>1741
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          <1884..>1939
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          1969..2353
                     /region_name="McrB"
                     /note="5-methylcytosine-specific restriction endonuclease
                     McrBC, GTP-binding regulatory subunit McrB [Defense
                     mechanisms]; COG1401"
                     /db_xref="CDD:441011"
     CDS             1..2466
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /coded_by="XM_054370372.1:860..8260"
                     /db_xref="GeneID:89797"
                     /db_xref="HGNC:HGNC:15997"
                     /db_xref="MIM:607026"
ORIGIN      
        1 mpailvaskm ksglpkpvhs aapilhvppa ragpqpcylk lgskvevskt typsqiplks
       61 qvlqglqepa geglplrksg svengfdtqi ytdwanhyla ksghkrlikd lqqdvtdgvl
      121 laqiiqvvan ekiedingcp knrsqmieni daclnflaak giniqglsae eirngnlkai
      181 lglffslsry kqqqqqpqkq hlssplppav sqvagapsqc qagtpqqqvp vtpqapcqph
      241 qpaphqqska qaemqssass kdssqskiir ftlgqkkisr lpgptarvsa agseaktrgg
      301 sttannrrsq sfnnydkskp vtspppppss hekeplassa sshpgmsdna paslesgsss
      361 tptncstssa ipqpgaatkp wrskslsvkh satvsmlsvk ppgpeaprpt peamkpapnn
      421 qksmleklkl fnskggskag egpgsrdtsc erletlpsfe eseeleaasr mlttvgpass
      481 spkialkgia qrtfsraltn kksslkgnek ekekqqrekd kekskdlakr asvterldlk
      541 eepkedpsga avpempkkss kiasfipkgg klnsakkepm apshsgipkp gmksmpgksp
      601 sapapskege rsrsgklssg lpqqkpqldg rhssssssla ssegkgpggt tlnhsissqt
      661 vsgsvgttqt tgsntvsvql pqpqqqynhp ntatvapfly rsqtdtegnv taessstgvs
      721 vepshftktg qpaleeltge dpearrlrtv kniadlrqnl eetmsslrgt qvthstlett
      781 fdtnvttems grsilsltgr ptplswrlgq ssprlqagda psmgngyppr anasrfinte
      841 sgryvysapl rrqlasrgss vchvdvsdka gdemdlegis mdapgymsdg dvlsknirtd
      901 ditsgymtdg glglytrrln rlpdgmavvr etlqrntslg lgdadswdds ssvssgisdt
      961 idnlstddin tsssissyan tpassrknld vqtdaekhsq vernslwsgd dvkksdggsd
     1021 sgikmepgsk wrrnpsdvsd esdkstsgkk npvisqtgsw rrgmtaqvgi tmprtkasap
     1081 agalktpgtg ktddakvsek grlspkasqv krspsdagrs sgdeskkplp sssrtptana
     1141 nsfgfkkqsg saaglamita sgvtvtsrsa tlgkipkssa lvsrsagrks smdgaqnqdd
     1201 gylalssrtn lqyrslprps ksnsrngagn rsstssidsn issksaglpv pklrepskta
     1261 lgsslpglvn qtdkekgiss dnesvascns vkvnpaaqpv sspaqtslqp gakypdvasp
     1321 tlrrlfggkp tkqvpiatae nmknsvvisn phatmtqqgn ldspsgsgvl ssgsssplys
     1381 knvdlnqspl asspssahsa psnsltwgtn assssavskd glgfqsvssl htscesidis
     1441 lssggvpshn sstgliassk ddsltpfvrt nsvkttlses dphldrntlp kkglrytpts
     1501 qlrtqedake wlrshsaggl qdtaanspfs sgssvtspsg trfnfsqlas pttvtqmsls
     1561 nptmlrthsl snadgqydpy tdsrfrnssm sldeksrtms rsgsfrdgfe eeswekssvd
     1621 nfvsrlhssl hfslplfhha ryelvhgssl slvsstssvy stpeekcqse irklrrelda
     1681 sqekvsaltt qltanahlva afeqslgnmt irlqsltmta eqkdselnel rktiellkkq
     1741 naaaqaaing vintpelnck gngtaqsadl rirrqhssds vssinsatsh ssvgsniesd
     1801 skkkkrknwv nelrssfkqa fgkkkspksa sshsdieemt dsslpsspkl phngstgstp
     1861 llrnshsnsl isecmdseae tvmqlrnelr dkemkltdir lealssahql dqlreamnrm
     1921 qseieklkae ndrlksesqg sgcsrapsqv sisasprqsm glsqhslnlt estsldmlld
     1981 dtgecsarke ggrhvkivvs fqeemkwked srphlfligc igvsgktkwd vldgvvrrlf
     2041 keyiihvdpv sqlglnsdsv lgysigeikr sntsetpell pcgylvgent tisvtvkgla
     2101 ensldslvfe slipkpilqr yvslliehrr iilsgpsgtg ktylanrlse yivlregrel
     2161 tdgviatfnv dhksskelrq ylsnladqcn sennavdmpl viildnlhhv sslgeifngl
     2221 lnckyhkcpy iigtmnqats stpnlqlhhn frwvlcanht epvkgflgrf lrrklmetei
     2281 sgrvrnmelv kiidwipkvw hhlnrfleah sssdvtigpr lflscpidvd gsrvwftdlw
     2341 nysiipylle aireglqlyg rrapwedpak wvmdtypwaa spqqhewppl lqlrpedvgf
     2401 dgysmpregs tskqmppsda egdplmnmlm rlqeaanyss pqsydsdsns nshhddilds
     2461 slestl
//
LOCUS       XP_054226348            2465 aa            linear   PRI 05-AUG-2025
DEFINITION  neuron navigator 2 isoform X3 [Homo sapiens].
ACCESSION   XP_054226348
VERSION     XP_054226348.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370373.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2465
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2465
                     /product="neuron navigator 2 isoform X3"
                     /calculated_mol_wt=265519
     Region          77..190
                     /region_name="CH_NAV2"
                     /note="calponin homology (CH) domain found in neuron
                     navigator 2; cd21285"
                     /db_xref="CDD:409134"
     Site            order(87,91,145,147..148,151..152,154,163..171,176,
                     178..179,181..182,185..186,189)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409134"
     Region          <207..>394
                     /region_name="PRK07003"
                     /note="DNA polymerase III subunit gamma/tau"
                     /db_xref="CDD:235906"
     Region          <286..715
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          946..>1298
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          <1664..>1936
                     /region_name="Mplasa_alph_rch"
                     /note="helix-rich Mycoplasma protein; TIGR04523"
                     /db_xref="CDD:275316"
     Region          1664..>1740
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          <1883..>1938
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          1968..2352
                     /region_name="McrB"
                     /note="5-methylcytosine-specific restriction endonuclease
                     McrBC, GTP-binding regulatory subunit McrB [Defense
                     mechanisms]; COG1401"
                     /db_xref="CDD:441011"
     CDS             1..2465
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /coded_by="XM_054370373.1:860..8257"
                     /db_xref="GeneID:89797"
                     /db_xref="HGNC:HGNC:15997"
                     /db_xref="MIM:607026"
ORIGIN      
        1 mpailvaskm ksglpkpvhs aapilhvppa ragpqpcylk lgskvevskt typsqiplks
       61 qvlqglqepa geglplrksg svengfdtqi ytdwanhyla ksghkrlikd lqqdvtdgvl
      121 laqiiqvvan ekiedingcp knrsqmieni daclnflaak giniqglsae eirngnlkai
      181 lglffslsry kqqqqqpqkq hlssplppav sqvagapsqc qagtpqqqvp vtpqapcqph
      241 qpaphqqska qaemqsrlpg ptarvsaags eaktrggstt annrrsqsfn nydkskpvts
      301 pppppsshek eplassassh pgmsdnapas lesgssstpt ncstssaipq pgaatkpwrs
      361 kslsvkhsat vsmlsvkppg peaprptpea mkpapnnqks mleklklfns kggskagegp
      421 gsrdtscerl etlpsfeese eleaasrmlt tvgpassspk ialkgiaqrt fsraltnkks
      481 slkgnekeke kqqrekdkek skdlakrasv terldlkeep kedpsgaavp empkksskia
      541 sfipkggkln sakkepmaps hsgipkpgmk smpgkspsap apskegersr sgklssglpq
      601 qkpqldgrhs ssssslasse gkgpggttln hsissqtvsg svgttqttgs ntvsvqlpqp
      661 qqqynhpnta tvapflyrsq tdtegnvtae ssstgvsvep shftktgqpa leeltgedpe
      721 arrlrtvkni adlrqnleet msslrgtqvt hstlettfdt nvttemsgrs ilsltgrptp
      781 lswrlgqssp rlqagdapsm gngypprana srfintesgr yvysaplrrq lasrgssvch
      841 vdvsdkagde mdlegismda pgymsdgdvl sknirtddit sgymtdgglg lytrrlnrlp
      901 dgmavvretl qrntslglgd adswddsssv ssgisdtidn lstddintss sissyantpa
      961 ssrknldvqt daekhsqver nslwsgddvk ksdggsdsgi kmepgskwrr npsdvsdesd
     1021 kstsgkknpv isqtgswrrg mtaqvgitmp rtkasapaga lktpgtgktd dakvsekgrl
     1081 spkasqvkrs psdagrssgd eskkplpsss rtptanansf gfkkqsgsaa glamitasgv
     1141 tvtsrsatlg kipkssalvs rsagrkssmd gaqnqddgyl alssrtnlqy rslprpsksn
     1201 srngagnrss tssidsniss ksaglpvpkl repsktalgs slpglvnqtd kekgissdne
     1261 svascnsvkv npaaqpvssp aqtslqpgak ypdvasptlr rlfggkptkq vpiataenmk
     1321 nsvvisnpha tmtqqgnlds psgsgvlssg sssplysknv dlnqsplass pssahsapsn
     1381 sltwgtnass ssavskdglg fqsvsslhts cesidislss ggvpshnsst gliasskdds
     1441 ltpfvrtnsv kttlsespls spaaspkfcr stlprkqdsd phldrntlpk kglrytptsq
     1501 lrtqedakew lrshsagglq dtaanspfss gssvtspsgt rfnfsqlasp ttvtqmslsn
     1561 ptmlrthsls nadgqydpyt dsrfrnssms ldeksrtmsr sgsfrdgfee eswekssvdn
     1621 fvsrlhsslh fslplfhhar yelvhgssls lvsstssvys tpeekcqsei rklrreldas
     1681 qekvsalttq ltanahlvaa feqslgnmti rlqsltmtae qkdselnelr ktiellkkqn
     1741 aaaqaaingv intpelnckg ngtaqsadlr irrqhssdsv ssinsatshs svgsniesds
     1801 kkkkrknwvn elrssfkqaf gkkkspksas shsdieemtd sslpsspklp hngstgstpl
     1861 lrnshsnsli secmdseaet vmqlrnelrd kemkltdirl ealssahqld qlreamnrmq
     1921 seieklkaen drlksesqgs gcsrapsqvs isasprqsmg lsqhslnlte stsldmlldd
     1981 tgecsarkeg grhvkivvsf qeemkwkeds rphlfligci gvsgktkwdv ldgvvrrlfk
     2041 eyiihvdpvs qlglnsdsvl gysigeikrs ntsetpellp cgylvgentt isvtvkglae
     2101 nsldslvfes lipkpilqry vslliehrri ilsgpsgtgk tylanrlsey ivlregrelt
     2161 dgviatfnvd hksskelrqy lsnladqcns ennavdmplv iildnlhhvs slgeifngll
     2221 nckyhkcpyi igtmnqatss tpnlqlhhnf rwvlcanhte pvkgflgrfl rrklmeteis
     2281 grvrnmelvk iidwipkvwh hlnrfleahs ssdvtigprl flscpidvdg srvwftdlwn
     2341 ysiipyllea ireglqlygr rapwedpakw vmdtypwaas pqqhewppll qlrpedvgfd
     2401 gysmpregst skqmppsdae gdplmnmlmr lqeaanyssp qsydsdsnsn shhddildss
     2461 lestl
//
LOCUS       XP_054226349            2463 aa            linear   PRI 05-AUG-2025
DEFINITION  neuron navigator 2 isoform X4 [Homo sapiens].
ACCESSION   XP_054226349
VERSION     XP_054226349.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370374.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2463
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2463
                     /product="neuron navigator 2 isoform X4"
                     /calculated_mol_wt=265299
     Region          77..190
                     /region_name="CH_NAV2"
                     /note="calponin homology (CH) domain found in neuron
                     navigator 2; cd21285"
                     /db_xref="CDD:409134"
     Site            order(87,91,145,147..148,151..152,154,163..171,176,
                     178..179,181..182,185..186,189)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409134"
     Region          <309..738
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          969..>1321
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          1665..>1741
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          1873..>1931
                     /region_name="Atg16_CCD"
                     /note="Coiled-coiled domain of autophagy-related 16
                     (Atg16) family proteins; cl46300"
                     /db_xref="CDD:480640"
     Region          1966..2350
                     /region_name="McrB"
                     /note="5-methylcytosine-specific restriction endonuclease
                     McrBC, GTP-binding regulatory subunit McrB [Defense
                     mechanisms]; COG1401"
                     /db_xref="CDD:441011"
     CDS             1..2463
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /coded_by="XM_054370374.1:860..8251"
                     /db_xref="GeneID:89797"
                     /db_xref="HGNC:HGNC:15997"
                     /db_xref="MIM:607026"
ORIGIN      
        1 mpailvaskm ksglpkpvhs aapilhvppa ragpqpcylk lgskvevskt typsqiplks
       61 qvlqglqepa geglplrksg svengfdtqi ytdwanhyla ksghkrlikd lqqdvtdgvl
      121 laqiiqvvan ekiedingcp knrsqmieni daclnflaak giniqglsae eirngnlkai
      181 lglffslsry kqqqqqpqkq hlssplppav sqvagapsqc qagtpqqqvp vtpqapcqph
      241 qpaphqqska qaemqssass kdssqskiir ftlgqkkisr lpgptarvsa agseaktrgg
      301 sttannrrsq sfnnydkskp vtspppppss hekeplassa sshpgmsdna paslesgsss
      361 tptncstssa ipqpgaatkp wrskslsvkh satvsmlsvk ppgpeaprpt peamkpapnn
      421 qksmleklkl fnskggskag egpgsrdtsc erletlpsfe eseeleaasr mlttvgpass
      481 spkialkgia qrtfsraltn kksslkgnek ekekqqrekd kekskdlakr asvterldlk
      541 eepkedpsga avpempkkss kiasfipkgg klnsakkepm apshsgipkp gmksmpgksp
      601 sapapskege rsrsgklssg lpqqkpqldg rhssssssla ssegkgpggt tlnhsissqt
      661 vsgsvgttqt tgsntvsvql pqpqqqynhp ntatvapfly rsqtdtegnv taessstgvs
      721 vepshftktg qpaleeltge dpearrlrtv kniadlrqnl eetmsslrgt qvthstlett
      781 fdtnvttems grsilsltgr ptplswrlgq ssprlqagda psmgngyppr anasrfinte
      841 sgryvysapl rrqlasrgss vchvdvsdka gdemdlegis mdapgymsdg dvlsknirtd
      901 ditsgymtdg glglytrrln rlpdgmavvr etlqrntslg lgdadswdds ssvssgisdt
      961 idnlstddin tsssissyan tpassrknld vqtdaekhsq vernslwsgd dvkksdggsd
     1021 sgikmepgsk wrrnpsdvsd esdkstsgkk npvisqtgsw rrgmtaqvgi tmprtkasap
     1081 agalktpgtg ktddakvsek grlspkasqv krspsdagrs sgdeskkplp sssrtptana
     1141 nsfgfkkqsg saaglamita sgvtvtsrsa tlgkipkssa lvsrsagrks smdgaqnqdd
     1201 gylalssrtn lqyrslprps ksnsrngagn rsstssidsn issksaglpv pklrepskta
     1261 lgsslpglvn qtdkekgiss dnesvascns vkvnpaaqpv sspaqtslqp gakypdvasp
     1321 tlrrlfggkp tkqvpiatae nmknsvvisn phatmtqqgn ldspsgsgvl ssgsssplys
     1381 knvdlnqspl asspssahsa psnsltwgtn assssavskd glgfqsvssl htscesidis
     1441 lssggvpshn sstgliassk ddsltpfvrt nsvkttlses dphldrntlp kkglrytpts
     1501 qlrtqedake wlrshsaggl qdtaanspfs sgssvtspsg trfnfsqlas pttvtqmsls
     1561 nptmlrthsl snadgqydpy tdsrfrnssm sldeksrtms rsgsfrdgfe eeswekssvd
     1621 nfvsrlhssl hfslplfhha ryelvhgssl slvsstssvy stpeekcqse irklrrelda
     1681 sqekvsaltt qltanahlva afeqslgnmt irlqsltmta eqkdselnel rktiellkkq
     1741 naaaqaaing vintpelnck gngtaqsadl rirrqhssds vssinsatsh ssvgsniesd
     1801 skkkkrknwl rssfkqafgk kkspksassh sdieemtdss lpsspklphn gstgstpllr
     1861 nshsnslise cmdseaetvm qlrnelrdke mkltdirlea lssahqldql reamnrmqse
     1921 ieklkaendr lksesqgsgc srapsqvsis asprqsmgls qhslnltest sldmllddtg
     1981 ecsarkeggr hvkivvsfqe emkwkedsrp hlfligcigv sgktkwdvld gvvrrlfkey
     2041 iihvdpvsql glnsdsvlgy sigeikrsnt setpellpcg ylvgenttis vtvkglaens
     2101 ldslvfesli pkpilqryvs lliehrriil sgpsgtgkty lanrlseyiv lregreltdg
     2161 viatfnvdhk sskelrqyls nladqcnsen navdmplvii ldnlhhvssl geifngllnc
     2221 kyhkcpyiig tmnqatsstp nlqlhhnfrw vlcanhtepv kgflgrflrr klmeteisgr
     2281 vrnmelvkii dwipkvwhhl nrfleahsss dvtigprlfl scpidvdgsr vwftdlwnys
     2341 iipylleair eglqlygrra pwedpakwvm dtypwaaspq qhewppllql rpedvgfdgy
     2401 smpregstsk qmppsdaegd plmnmlmrlq eaanysspqs ydsdsnsnsh hddildssle
     2461 stl
//
LOCUS       XP_054226350            2462 aa            linear   PRI 05-AUG-2025
DEFINITION  neuron navigator 2 isoform X5 [Homo sapiens].
ACCESSION   XP_054226350
VERSION     XP_054226350.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370375.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2462
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2462
                     /product="neuron navigator 2 isoform X5"
                     /calculated_mol_wt=265176
     Region          77..190
                     /region_name="CH_NAV2"
                     /note="calponin homology (CH) domain found in neuron
                     navigator 2; cd21285"
                     /db_xref="CDD:409134"
     Site            order(87,91,145,147..148,151..152,154,163..171,176,
                     178..179,181..182,185..186,189)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409134"
     Region          <207..>394
                     /region_name="PRK07003"
                     /note="DNA polymerase III subunit gamma/tau"
                     /db_xref="CDD:235906"
     Region          <286..715
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          946..>1298
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          <1664..>1933
                     /region_name="Mplasa_alph_rch"
                     /note="helix-rich Mycoplasma protein; TIGR04523"
                     /db_xref="CDD:275316"
     Region          1664..>1740
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          <1880..>1935
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          1965..2349
                     /region_name="McrB"
                     /note="5-methylcytosine-specific restriction endonuclease
                     McrBC, GTP-binding regulatory subunit McrB [Defense
                     mechanisms]; COG1401"
                     /db_xref="CDD:441011"
     CDS             1..2462
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /coded_by="XM_054370375.1:860..8248"
                     /db_xref="GeneID:89797"
                     /db_xref="HGNC:HGNC:15997"
                     /db_xref="MIM:607026"
ORIGIN      
        1 mpailvaskm ksglpkpvhs aapilhvppa ragpqpcylk lgskvevskt typsqiplks
       61 qvlqglqepa geglplrksg svengfdtqi ytdwanhyla ksghkrlikd lqqdvtdgvl
      121 laqiiqvvan ekiedingcp knrsqmieni daclnflaak giniqglsae eirngnlkai
      181 lglffslsry kqqqqqpqkq hlssplppav sqvagapsqc qagtpqqqvp vtpqapcqph
      241 qpaphqqska qaemqsrlpg ptarvsaags eaktrggstt annrrsqsfn nydkskpvts
      301 pppppsshek eplassassh pgmsdnapas lesgssstpt ncstssaipq pgaatkpwrs
      361 kslsvkhsat vsmlsvkppg peaprptpea mkpapnnqks mleklklfns kggskagegp
      421 gsrdtscerl etlpsfeese eleaasrmlt tvgpassspk ialkgiaqrt fsraltnkks
      481 slkgnekeke kqqrekdkek skdlakrasv terldlkeep kedpsgaavp empkksskia
      541 sfipkggkln sakkepmaps hsgipkpgmk smpgkspsap apskegersr sgklssglpq
      601 qkpqldgrhs ssssslasse gkgpggttln hsissqtvsg svgttqttgs ntvsvqlpqp
      661 qqqynhpnta tvapflyrsq tdtegnvtae ssstgvsvep shftktgqpa leeltgedpe
      721 arrlrtvkni adlrqnleet msslrgtqvt hstlettfdt nvttemsgrs ilsltgrptp
      781 lswrlgqssp rlqagdapsm gngypprana srfintesgr yvysaplrrq lasrgssvch
      841 vdvsdkagde mdlegismda pgymsdgdvl sknirtddit sgymtdgglg lytrrlnrlp
      901 dgmavvretl qrntslglgd adswddsssv ssgisdtidn lstddintss sissyantpa
      961 ssrknldvqt daekhsqver nslwsgddvk ksdggsdsgi kmepgskwrr npsdvsdesd
     1021 kstsgkknpv isqtgswrrg mtaqvgitmp rtkasapaga lktpgtgktd dakvsekgrl
     1081 spkasqvkrs psdagrssgd eskkplpsss rtptanansf gfkkqsgsaa glamitasgv
     1141 tvtsrsatlg kipkssalvs rsagrkssmd gaqnqddgyl alssrtnlqy rslprpsksn
     1201 srngagnrss tssidsniss ksaglpvpkl repsktalgs slpglvnqtd kekgissdne
     1261 svascnsvkv npaaqpvssp aqtslqpgak ypdvasptlr rlfggkptkq vpiataenmk
     1321 nsvvisnpha tmtqqgnlds psgsgvlssg sssplysknv dlnqsplass pssahsapsn
     1381 sltwgtnass ssavskdglg fqsvsslhts cesidislss ggvpshnsst gliasskdds
     1441 ltpfvrtnsv kttlsespls spaaspkfcr stlprkqdsd phldrntlpk kglrytptsq
     1501 lrtqedakew lrshsagglq dtaanspfss gssvtspsgt rfnfsqlasp ttvtqmslsn
     1561 ptmlrthsls nadgqydpyt dsrfrnssms ldeksrtmsr sgsfrdgfee eswekssvdn
     1621 fvsrlhsslh fslplfhhar yelvhgssls lvsstssvys tpeekcqsei rklrreldas
     1681 qekvsalttq ltanahlvaa feqslgnmti rlqsltmtae qkdselnelr ktiellkkqn
     1741 aaaqaaingv intpelnckg ngtaqsadlr irrqhssdsv ssinsatshs svgsniesds
     1801 kkkkrknwlr ssfkqafgkk kspksasshs dieemtdssl psspklphng stgstpllrn
     1861 shsnslisec mdseaetvmq lrnelrdkem kltdirleal ssahqldqlr eamnrmqsei
     1921 eklkaendrl ksesqgsgcs rapsqvsisa sprqsmglsq hslnltests ldmllddtge
     1981 csarkeggrh vkivvsfqee mkwkedsrph lfligcigvs gktkwdvldg vvrrlfkeyi
     2041 ihvdpvsqlg lnsdsvlgys igeikrsnts etpellpcgy lvgenttisv tvkglaensl
     2101 dslvfeslip kpilqryvsl liehrriils gpsgtgktyl anrlseyivl regreltdgv
     2161 iatfnvdhks skelrqylsn ladqcnsenn avdmplviil dnlhhvsslg eifngllnck
     2221 yhkcpyiigt mnqatsstpn lqlhhnfrwv lcanhtepvk gflgrflrrk lmeteisgrv
     2281 rnmelvkiid wipkvwhhln rfleahsssd vtigprlfls cpidvdgsrv wftdlwnysi
     2341 ipylleaire glqlygrrap wedpakwvmd typwaaspqq hewppllqlr pedvgfdgys
     2401 mpregstskq mppsdaegdp lmnmlmrlqe aanysspqsy dsdsnsnshh ddildssles
     2461 tl
//
LOCUS       XP_054226351            2455 aa            linear   PRI 05-AUG-2025
DEFINITION  neuron navigator 2 isoform X6 [Homo sapiens].
ACCESSION   XP_054226351
VERSION     XP_054226351.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370376.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2455
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2455
                     /product="neuron navigator 2 isoform X6"
                     /calculated_mol_wt=264059
     Region          77..190
                     /region_name="CH_NAV2"
                     /note="calponin homology (CH) domain found in neuron
                     navigator 2; cd21285"
                     /db_xref="CDD:409134"
     Site            order(87,91,145,147..148,151..152,154,163..171,176,
                     178..179,181..182,185..186,189)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409134"
     Region          <309..738
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          969..>1321
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          <1654..>1926
                     /region_name="Mplasa_alph_rch"
                     /note="helix-rich Mycoplasma protein; TIGR04523"
                     /db_xref="CDD:275316"
     Region          1654..>1730
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          1865..>1923
                     /region_name="Atg16_CCD"
                     /note="Coiled-coiled domain of autophagy-related 16
                     (Atg16) family proteins; cl46300"
                     /db_xref="CDD:480640"
     Region          1958..2342
                     /region_name="McrB"
                     /note="5-methylcytosine-specific restriction endonuclease
                     McrBC, GTP-binding regulatory subunit McrB [Defense
                     mechanisms]; COG1401"
                     /db_xref="CDD:441011"
     CDS             1..2455
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /coded_by="XM_054370376.1:860..8227"
                     /db_xref="GeneID:89797"
                     /db_xref="HGNC:HGNC:15997"
                     /db_xref="MIM:607026"
ORIGIN      
        1 mpailvaskm ksglpkpvhs aapilhvppa ragpqpcylk lgskvevskt typsqiplks
       61 qvlqglqepa geglplrksg svengfdtqi ytdwanhyla ksghkrlikd lqqdvtdgvl
      121 laqiiqvvan ekiedingcp knrsqmieni daclnflaak giniqglsae eirngnlkai
      181 lglffslsry kqqqqqpqkq hlssplppav sqvagapsqc qagtpqqqvp vtpqapcqph
      241 qpaphqqska qaemqssass kdssqskiir ftlgqkkisr lpgptarvsa agseaktrgg
      301 sttannrrsq sfnnydkskp vtspppppss hekeplassa sshpgmsdna paslesgsss
      361 tptncstssa ipqpgaatkp wrskslsvkh satvsmlsvk ppgpeaprpt peamkpapnn
      421 qksmleklkl fnskggskag egpgsrdtsc erletlpsfe eseeleaasr mlttvgpass
      481 spkialkgia qrtfsraltn kksslkgnek ekekqqrekd kekskdlakr asvterldlk
      541 eepkedpsga avpempkkss kiasfipkgg klnsakkepm apshsgipkp gmksmpgksp
      601 sapapskege rsrsgklssg lpqqkpqldg rhssssssla ssegkgpggt tlnhsissqt
      661 vsgsvgttqt tgsntvsvql pqpqqqynhp ntatvapfly rsqtdtegnv taessstgvs
      721 vepshftktg qpaleeltge dpearrlrtv kniadlrqnl eetmsslrgt qvthstlett
      781 fdtnvttems grsilsltgr ptplswrlgq ssprlqagda psmgngyppr anasrfinte
      841 sgryvysapl rrqlasrgss vchvdvsdka gdemdlegis mdapgymsdg dvlsknirtd
      901 ditsgymtdg glglytrrln rlpdgmavvr etlqrntslg lgdadswdds ssvssgisdt
      961 idnlstddin tsssissyan tpassrknld vqtdaekhsq vernslwsgd dvkksdggsd
     1021 sgikmepgsk wrrnpsdvsd esdkstsgkk npvisqtgsw rrgmtaqvgi tmprtkasap
     1081 agalktpgtg ktddakvsek grlspkasqv krspsdagrs sgdeskkplp sssrtptana
     1141 nsfgfkkqsg saaglamita sgvtvtsrsa tlgkipkssa lvsrsagrks smdgaqnqdd
     1201 gylalssrtn lqyrslprps ksnsrngagn rsstssidsn issksaglpv pklrepskta
     1261 lgsslpglvn qtdkekgiss dnesvascns vkvnpaaqpv sspaqtslqp gakypdvasp
     1321 tlrrlfggkp tkqvpiatae nmknsvvisn phatmtqqgn ldspsgsgvl ssgsssplys
     1381 knvdlnqspl asspssahsa psnsltwgtn assssavskd glgfqsvssl htscesidis
     1441 lssggvpshn sstgliassk ddsltpfvrt nsvkttlses plsspaaspk fcrstlprkq
     1501 dsdphldrnt lpkkglrytp tsqlrtqeda kewlrshsag glqdtaansp fssgssvtsp
     1561 sgtrfnfsql aspttvtqms lsnptmlrth slsnadgqyd pytdsrfrns smsldeksrt
     1621 msrsgsfrdg feevhgssls lvsstssvys tpeekcqsei rklrreldas qekvsalttq
     1681 ltanahlvaa feqslgnmti rlqsltmtae qkdselnelr ktiellkkqn aaaqaaingv
     1741 intpelnckg ngtaqsadlr irrqhssdsv ssinsatshs svgsniesds kkkkrknwvn
     1801 elrssfkqaf gkkkspksas shsdieemtd sslpsspklp hngstgstpl lrnshsnsli
     1861 secmdseaet vmqlrnelrd kemkltdirl ealssahqld qlreamnrmq seieklkaen
     1921 drlksesqgs gcsrapsqvs isasprqsmg lsqhslnlte stsldmlldd tgecsarkeg
     1981 grhvkivvsf qeemkwkeds rphlfligci gvsgktkwdv ldgvvrrlfk eyiihvdpvs
     2041 qlglnsdsvl gysigeikrs ntsetpellp cgylvgentt isvtvkglae nsldslvfes
     2101 lipkpilqry vslliehrri ilsgpsgtgk tylanrlsey ivlregrelt dgviatfnvd
     2161 hksskelrqy lsnladqcns ennavdmplv iildnlhhvs slgeifngll nckyhkcpyi
     2221 igtmnqatss tpnlqlhhnf rwvlcanhte pvkgflgrfl rrklmeteis grvrnmelvk
     2281 iidwipkvwh hlnrfleahs ssdvtigprl flscpidvdg srvwftdlwn ysiipyllea
     2341 ireglqlygr rapwedpakw vmdtypwaas pqqhewppll qlrpedvgfd gysmpregst
     2401 skqmppsdae gdplmnmlmr lqeaanyssp qsydsdsnsn shhddildss lestl
//
LOCUS       XP_054226352            2452 aa            linear   PRI 05-AUG-2025
DEFINITION  neuron navigator 2 isoform X7 [Homo sapiens].
ACCESSION   XP_054226352
VERSION     XP_054226352.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370377.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2452
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2452
                     /product="neuron navigator 2 isoform X7"
                     /calculated_mol_wt=263717
     Region          77..190
                     /region_name="CH_NAV2"
                     /note="calponin homology (CH) domain found in neuron
                     navigator 2; cd21285"
                     /db_xref="CDD:409134"
     Site            order(87,91,145,147..148,151..152,154,163..171,176,
                     178..179,181..182,185..186,189)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409134"
     Region          <309..738
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          966..>1267
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          1654..>1730
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          1862..>1920
                     /region_name="Atg16_CCD"
                     /note="Coiled-coiled domain of autophagy-related 16
                     (Atg16) family proteins; cl46300"
                     /db_xref="CDD:480640"
     Region          1955..2339
                     /region_name="McrB"
                     /note="5-methylcytosine-specific restriction endonuclease
                     McrBC, GTP-binding regulatory subunit McrB [Defense
                     mechanisms]; COG1401"
                     /db_xref="CDD:441011"
     CDS             1..2452
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /coded_by="XM_054370377.1:860..8218"
                     /db_xref="GeneID:89797"
                     /db_xref="HGNC:HGNC:15997"
                     /db_xref="MIM:607026"
ORIGIN      
        1 mpailvaskm ksglpkpvhs aapilhvppa ragpqpcylk lgskvevskt typsqiplks
       61 qvlqglqepa geglplrksg svengfdtqi ytdwanhyla ksghkrlikd lqqdvtdgvl
      121 laqiiqvvan ekiedingcp knrsqmieni daclnflaak giniqglsae eirngnlkai
      181 lglffslsry kqqqqqpqkq hlssplppav sqvagapsqc qagtpqqqvp vtpqapcqph
      241 qpaphqqska qaemqssass kdssqskiir ftlgqkkisr lpgptarvsa agseaktrgg
      301 sttannrrsq sfnnydkskp vtspppppss hekeplassa sshpgmsdna paslesgsss
      361 tptncstssa ipqpgaatkp wrskslsvkh satvsmlsvk ppgpeaprpt peamkpapnn
      421 qksmleklkl fnskggskag egpgsrdtsc erletlpsfe eseeleaasr mlttvgpass
      481 spkialkgia qrtfsraltn kksslkgnek ekekqqrekd kekskdlakr asvterldlk
      541 eepkedpsga avpempkkss kiasfipkgg klnsakkepm apshsgipkp gmksmpgksp
      601 sapapskege rsrsgklssg lpqqkpqldg rhssssssla ssegkgpggt tlnhsissqt
      661 vsgsvgttqt tgsntvsvql pqpqqqynhp ntatvapfly rsqtdtegnv taessstgvs
      721 vepshftktg qpaleeltge dpearrlrtv kniadlrqnl eetmsslrgt qvthstlett
      781 fdtnvttems grsilsltgr ptplswrlgq ssprlqagda psmgngyppr anasrfinte
      841 sgryvysapl rrqlasrgss vchvdvsdka gdemdlegis mdapgymsdg dvlsknirtd
      901 ditsgymtdg glglytrrln rlpdgmavvr etlqrntslg lgdadswdds ssvssgisdt
      961 idnlstddin tsssissyan tpassrknld vqtdaekhsq vernslwsgd dvkksdggsd
     1021 sgikmepgsk wrrnpsdvsd esdkstsgkk npvisqtgsw rrgmtaqvgi tmprtkasap
     1081 agalktpgtg ktddakvsek grlspkasqv krspsdagrs sgdeskkplp sssrtptana
     1141 nsfgfkkqsg saaglamita sgvtvtsrsa tlgkipkssa lvsrsagrks smdgaqnqdd
     1201 gylalssrtn lqyrslprps ksnsrngagn rsstssidsn issksaglpv pklrepskta
     1261 lgsslpglvn qtdkekgiss dnesvascns vkvnpaaqpv sspaqtslqp gakypdvasp
     1321 tlrrlfggkp tkqvpiatae nmknsvvisn phatmtqqgn ldspsgsgvl ssgsssplys
     1381 knvdlnqspl asspssahsa psnsltwgtn assssavskd glgfqsvssl htscesidis
     1441 lssggvpshn sstgliassk ddsltpfvrt nsvkttlses plsspaaspk fcrstlprkq
     1501 dsdphldrnt lpkkglrytp tsqlrtqeda kewlrshsag glqdtaansp fssgssvtsp
     1561 sgtrfnfsql aspttvtqms lsnptmlrth slsnadgqyd pytdsrfrns smsldeksrt
     1621 msrsgsfrdg feevhgssls lvsstssvys tpeekcqsei rklrreldas qekvsalttq
     1681 ltanahlvaa feqslgnmti rlqsltmtae qkdselnelr ktiellkkqn aaaqaaingv
     1741 intpelnckg ngtaqsadlr irrqhssdsv ssinsatshs svgsniesds kkkkrknwlr
     1801 ssfkqafgkk kspksasshs dieemtdssl psspklphng stgstpllrn shsnslisec
     1861 mdseaetvmq lrnelrdkem kltdirleal ssahqldqlr eamnrmqsei eklkaendrl
     1921 ksesqgsgcs rapsqvsisa sprqsmglsq hslnltests ldmllddtge csarkeggrh
     1981 vkivvsfqee mkwkedsrph lfligcigvs gktkwdvldg vvrrlfkeyi ihvdpvsqlg
     2041 lnsdsvlgys igeikrsnts etpellpcgy lvgenttisv tvkglaensl dslvfeslip
     2101 kpilqryvsl liehrriils gpsgtgktyl anrlseyivl regreltdgv iatfnvdhks
     2161 skelrqylsn ladqcnsenn avdmplviil dnlhhvsslg eifngllnck yhkcpyiigt
     2221 mnqatsstpn lqlhhnfrwv lcanhtepvk gflgrflrrk lmeteisgrv rnmelvkiid
     2281 wipkvwhhln rfleahsssd vtigprlfls cpidvdgsrv wftdlwnysi ipylleaire
     2341 glqlygrrap wedpakwvmd typwaaspqq hewppllqlr pedvgfdgys mpregstskq
     2401 mppsdaegdp lmnmlmrlqe aanysspqsy dsdsnsnshh ddildssles tl
//
LOCUS       XP_054226353            2451 aa            linear   PRI 05-AUG-2025
DEFINITION  neuron navigator 2 isoform X8 [Homo sapiens].
ACCESSION   XP_054226353
VERSION     XP_054226353.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370378.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2451
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2451
                     /product="neuron navigator 2 isoform X8"
                     /calculated_mol_wt=263969
     Region          77..190
                     /region_name="CH_NAV2"
                     /note="calponin homology (CH) domain found in neuron
                     navigator 2; cd21285"
                     /db_xref="CDD:409134"
     Site            order(87,91,145,147..148,151..152,154,163..171,176,
                     178..179,181..182,185..186,189)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409134"
     Region          <309..738
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          966..>1267
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          <1650..>1922
                     /region_name="Mplasa_alph_rch"
                     /note="helix-rich Mycoplasma protein; TIGR04523"
                     /db_xref="CDD:275316"
     Region          1650..>1726
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          1861..>1919
                     /region_name="Atg16_CCD"
                     /note="Coiled-coiled domain of autophagy-related 16
                     (Atg16) family proteins; cl46300"
                     /db_xref="CDD:480640"
     Region          1954..2338
                     /region_name="McrB"
                     /note="5-methylcytosine-specific restriction endonuclease
                     McrBC, GTP-binding regulatory subunit McrB [Defense
                     mechanisms]; COG1401"
                     /db_xref="CDD:441011"
     CDS             1..2451
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /coded_by="XM_054370378.1:860..8215"
                     /db_xref="GeneID:89797"
                     /db_xref="HGNC:HGNC:15997"
                     /db_xref="MIM:607026"
ORIGIN      
        1 mpailvaskm ksglpkpvhs aapilhvppa ragpqpcylk lgskvevskt typsqiplks
       61 qvlqglqepa geglplrksg svengfdtqi ytdwanhyla ksghkrlikd lqqdvtdgvl
      121 laqiiqvvan ekiedingcp knrsqmieni daclnflaak giniqglsae eirngnlkai
      181 lglffslsry kqqqqqpqkq hlssplppav sqvagapsqc qagtpqqqvp vtpqapcqph
      241 qpaphqqska qaemqssass kdssqskiir ftlgqkkisr lpgptarvsa agseaktrgg
      301 sttannrrsq sfnnydkskp vtspppppss hekeplassa sshpgmsdna paslesgsss
      361 tptncstssa ipqpgaatkp wrskslsvkh satvsmlsvk ppgpeaprpt peamkpapnn
      421 qksmleklkl fnskggskag egpgsrdtsc erletlpsfe eseeleaasr mlttvgpass
      481 spkialkgia qrtfsraltn kksslkgnek ekekqqrekd kekskdlakr asvterldlk
      541 eepkedpsga avpempkkss kiasfipkgg klnsakkepm apshsgipkp gmksmpgksp
      601 sapapskege rsrsgklssg lpqqkpqldg rhssssssla ssegkgpggt tlnhsissqt
      661 vsgsvgttqt tgsntvsvql pqpqqqynhp ntatvapfly rsqtdtegnv taessstgvs
      721 vepshftktg qpaleeltge dpearrlrtv kniadlrqnl eetmsslrgt qvthstlett
      781 fdtnvttems grsilsltgr ptplswrlgq ssprlqagda psmgngyppr anasrfinte
      841 sgryvysapl rrqlasrgss vchvdvsdka gdemdlegis mdapgymsdg dvlsknirtd
      901 ditsgymtdg glglytrrln rlpdgmavvr etlqrntslg lgdadswdds ssvssgisdt
      961 idnlstddin tsssissyan tpassrknld vqtdaekhsq vernslwsgd dvkksdggsd
     1021 sgikmepgsk wrrnpsdvsd esdkstsgkk npvisqtgsw rrgmtaqvgi tmprtkasap
     1081 agalktpgtg ktddakvsek grlspkasqv krspsdagrs sgdeskkplp sssrtptana
     1141 nsfgfkkqsg saaglamita sgvtvtsrsa tlgkipkssa lvsrsagrks smdgaqnqdd
     1201 gylalssrtn lqyrslprps ksnsrngagn rsstssidsn issksaglpv pklrepskta
     1261 lgsslpglvn qtdkekgiss dnesvascns vkvnpaaqpv sspaqtslqp gakypdvasp
     1321 tlrrlfggkp tkqvpiatae nmknsvvisn phatmtqqgn ldspsgsgvl ssgsssplys
     1381 knvdlnqspl asspssahsa psnsltwgtn assssavskd glgfqsvssl htscesidis
     1441 lssggvpshn sstgliassk ddsltpfvrt nsvkttlser ytptsqlrtq edakewlrsh
     1501 sagglqdtaa nspfssgssv tspsgtrfnf sqlaspttvt qmslsnptml rthslsnadg
     1561 qydpytdsrf rnssmsldek srtmsrsgsf rdgfeeeswe kssvdnfvsr lhsslhfslp
     1621 lfhharyelv hgsslslvss tssvystpee kcqseirklr reldasqekv salttqltan
     1681 ahlvaafeqs lgnmtirlqs ltmtaeqkds elnelrktie llkkqnaaaq aaingvintp
     1741 elnckgngta qsadlrirrq hssdsvssin satshssvgs niesdskkkk rknwvnelrs
     1801 sfkqafgkkk spksasshsd ieemtdsslp sspklphngs tgstpllrns hsnslisecm
     1861 dseaetvmql rnelrdkemk ltdirleals sahqldqlre amnrmqseie klkaendrlk
     1921 sesqgsgcsr apsqvsisas prqsmglsqh slnltestsl dmllddtgec sarkeggrhv
     1981 kivvsfqeem kwkedsrphl fligcigvsg ktkwdvldgv vrrlfkeyii hvdpvsqlgl
     2041 nsdsvlgysi geikrsntse tpellpcgyl vgenttisvt vkglaensld slvfeslipk
     2101 pilqryvsll iehrriilsg psgtgktyla nrlseyivlr egreltdgvi atfnvdhkss
     2161 kelrqylsnl adqcnsenna vdmplviild nlhhvsslge ifngllncky hkcpyiigtm
     2221 nqatsstpnl qlhhnfrwvl canhtepvkg flgrflrrkl meteisgrvr nmelvkiidw
     2281 ipkvwhhlnr fleahsssdv tigprlflsc pidvdgsrvw ftdlwnysii pylleaireg
     2341 lqlygrrapw edpakwvmdt ypwaaspqqh ewppllqlrp edvgfdgysm pregstskqm
     2401 ppsdaegdpl mnmlmrlqea anysspqsyd sdsnsnshhd dildsslest l
//
LOCUS       XP_054226354            2448 aa            linear   PRI 05-AUG-2025
DEFINITION  neuron navigator 2 isoform X9 [Homo sapiens].
ACCESSION   XP_054226354
VERSION     XP_054226354.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370379.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2448
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2448
                     /product="neuron navigator 2 isoform X9"
                     /calculated_mol_wt=263626
     Region          77..190
                     /region_name="CH_NAV2"
                     /note="calponin homology (CH) domain found in neuron
                     navigator 2; cd21285"
                     /db_xref="CDD:409134"
     Site            order(87,91,145,147..148,151..152,154,163..171,176,
                     178..179,181..182,185..186,189)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409134"
     Region          <309..738
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          966..>1267
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          1650..>1726
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          1858..>1916
                     /region_name="Atg16_CCD"
                     /note="Coiled-coiled domain of autophagy-related 16
                     (Atg16) family proteins; cl46300"
                     /db_xref="CDD:480640"
     Region          1951..2335
                     /region_name="McrB"
                     /note="5-methylcytosine-specific restriction endonuclease
                     McrBC, GTP-binding regulatory subunit McrB [Defense
                     mechanisms]; COG1401"
                     /db_xref="CDD:441011"
     CDS             1..2448
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /coded_by="XM_054370379.1:860..8206"
                     /db_xref="GeneID:89797"
                     /db_xref="HGNC:HGNC:15997"
                     /db_xref="MIM:607026"
ORIGIN      
        1 mpailvaskm ksglpkpvhs aapilhvppa ragpqpcylk lgskvevskt typsqiplks
       61 qvlqglqepa geglplrksg svengfdtqi ytdwanhyla ksghkrlikd lqqdvtdgvl
      121 laqiiqvvan ekiedingcp knrsqmieni daclnflaak giniqglsae eirngnlkai
      181 lglffslsry kqqqqqpqkq hlssplppav sqvagapsqc qagtpqqqvp vtpqapcqph
      241 qpaphqqska qaemqssass kdssqskiir ftlgqkkisr lpgptarvsa agseaktrgg
      301 sttannrrsq sfnnydkskp vtspppppss hekeplassa sshpgmsdna paslesgsss
      361 tptncstssa ipqpgaatkp wrskslsvkh satvsmlsvk ppgpeaprpt peamkpapnn
      421 qksmleklkl fnskggskag egpgsrdtsc erletlpsfe eseeleaasr mlttvgpass
      481 spkialkgia qrtfsraltn kksslkgnek ekekqqrekd kekskdlakr asvterldlk
      541 eepkedpsga avpempkkss kiasfipkgg klnsakkepm apshsgipkp gmksmpgksp
      601 sapapskege rsrsgklssg lpqqkpqldg rhssssssla ssegkgpggt tlnhsissqt
      661 vsgsvgttqt tgsntvsvql pqpqqqynhp ntatvapfly rsqtdtegnv taessstgvs
      721 vepshftktg qpaleeltge dpearrlrtv kniadlrqnl eetmsslrgt qvthstlett
      781 fdtnvttems grsilsltgr ptplswrlgq ssprlqagda psmgngyppr anasrfinte
      841 sgryvysapl rrqlasrgss vchvdvsdka gdemdlegis mdapgymsdg dvlsknirtd
      901 ditsgymtdg glglytrrln rlpdgmavvr etlqrntslg lgdadswdds ssvssgisdt
      961 idnlstddin tsssissyan tpassrknld vqtdaekhsq vernslwsgd dvkksdggsd
     1021 sgikmepgsk wrrnpsdvsd esdkstsgkk npvisqtgsw rrgmtaqvgi tmprtkasap
     1081 agalktpgtg ktddakvsek grlspkasqv krspsdagrs sgdeskkplp sssrtptana
     1141 nsfgfkkqsg saaglamita sgvtvtsrsa tlgkipkssa lvsrsagrks smdgaqnqdd
     1201 gylalssrtn lqyrslprps ksnsrngagn rsstssidsn issksaglpv pklrepskta
     1261 lgsslpglvn qtdkekgiss dnesvascns vkvnpaaqpv sspaqtslqp gakypdvasp
     1321 tlrrlfggkp tkqvpiatae nmknsvvisn phatmtqqgn ldspsgsgvl ssgsssplys
     1381 knvdlnqspl asspssahsa psnsltwgtn assssavskd glgfqsvssl htscesidis
     1441 lssggvpshn sstgliassk ddsltpfvrt nsvkttlser ytptsqlrtq edakewlrsh
     1501 sagglqdtaa nspfssgssv tspsgtrfnf sqlaspttvt qmslsnptml rthslsnadg
     1561 qydpytdsrf rnssmsldek srtmsrsgsf rdgfeeeswe kssvdnfvsr lhsslhfslp
     1621 lfhharyelv hgsslslvss tssvystpee kcqseirklr reldasqekv salttqltan
     1681 ahlvaafeqs lgnmtirlqs ltmtaeqkds elnelrktie llkkqnaaaq aaingvintp
     1741 elnckgngta qsadlrirrq hssdsvssin satshssvgs niesdskkkk rknwlrssfk
     1801 qafgkkkspk sasshsdiee mtdsslpssp klphngstgs tpllrnshsn slisecmdse
     1861 aetvmqlrne lrdkemkltd irlealssah qldqlreamn rmqseieklk aendrlkses
     1921 qgsgcsraps qvsisasprq smglsqhsln ltestsldml lddtgecsar keggrhvkiv
     1981 vsfqeemkwk edsrphlfli gcigvsgktk wdvldgvvrr lfkeyiihvd pvsqlglnsd
     2041 svlgysigei krsntsetpe llpcgylvge nttisvtvkg laensldslv feslipkpil
     2101 qryvsllieh rriilsgpsg tgktylanrl seyivlregr eltdgviatf nvdhksskel
     2161 rqylsnladq cnsennavdm plviildnlh hvsslgeifn gllnckyhkc pyiigtmnqa
     2221 tsstpnlqlh hnfrwvlcan htepvkgflg rflrrklmet eisgrvrnme lvkiidwipk
     2281 vwhhlnrfle ahsssdvtig prlflscpid vdgsrvwftd lwnysiipyl leaireglql
     2341 ygrrapwedp akwvmdtypw aaspqqhewp pllqlrpedv gfdgysmpre gstskqmpps
     2401 daegdplmnm lmrlqeaany sspqsydsds nsnshhddil dsslestl
//
LOCUS       XP_054226355            2445 aa            linear   PRI 05-AUG-2025
DEFINITION  neuron navigator 2 isoform X10 [Homo sapiens].
ACCESSION   XP_054226355
VERSION     XP_054226355.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370380.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2445
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2445
                     /product="neuron navigator 2 isoform X10"
                     /calculated_mol_wt=263429
     Region          42..147
                     /region_name="CH_NAV2"
                     /note="calponin homology (CH) domain found in neuron
                     navigator 2; cd21285"
                     /db_xref="CDD:409134"
     Site            order(44,48,102,104..105,108..109,111,120..128,133,
                     135..136,138..139,142..143,146)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409134"
     Region          <266..695
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          923..>1224
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          <1644..>1916
                     /region_name="Mplasa_alph_rch"
                     /note="helix-rich Mycoplasma protein; TIGR04523"
                     /db_xref="CDD:275316"
     Region          1644..>1720
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          <1863..>1918
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          1948..2332
                     /region_name="McrB"
                     /note="5-methylcytosine-specific restriction endonuclease
                     McrBC, GTP-binding regulatory subunit McrB [Defense
                     mechanisms]; COG1401"
                     /db_xref="CDD:441011"
     CDS             1..2445
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /coded_by="XM_054370380.1:860..8197"
                     /db_xref="GeneID:89797"
                     /db_xref="HGNC:HGNC:15997"
                     /db_xref="MIM:607026"
ORIGIN      
        1 mpailvaskm ksglpkpvhs aapilhvppa ragpqpcylk lgskveiytd wanhylaksg
       61 hkrlikdlqq dvtdgvllaq iiqvvaneki edingcpknr sqmienidac lnflaakgin
      121 iqglsaeeir ngnlkailgl ffslsrykqq qqqpqkqhls splppavsqv agapsqcqag
      181 tpqqqvpvtp qapcqphqpa phqqskaqae mqssasskds sqskiirftl gqkkisrlpg
      241 ptarvsaags eaktrggstt annrrsqsfn nydkskpvts pppppsshek eplassassh
      301 pgmsdnapas lesgssstpt ncstssaipq pgaatkpwrs kslsvkhsat vsmlsvkppg
      361 peaprptpea mkpapnnqks mleklklfns kggskagegp gsrdtscerl etlpsfeese
      421 eleaasrmlt tvgpassspk ialkgiaqrt fsraltnkks slkgnekeke kqqrekdkek
      481 skdlakrasv terldlkeep kedpsgaavp empkksskia sfipkggkln sakkepmaps
      541 hsgipkpgmk smpgkspsap apskegersr sgklssglpq qkpqldgrhs ssssslasse
      601 gkgpggttln hsissqtvsg svgttqttgs ntvsvqlpqp qqqynhpnta tvapflyrsq
      661 tdtegnvtae ssstgvsvep shftktgqpa leeltgedpe arrlrtvkni adlrqnleet
      721 msslrgtqvt hstlettfdt nvttemsgrs ilsltgrptp lswrlgqssp rlqagdapsm
      781 gngypprana srfintesgr yvysaplrrq lasrgssvch vdvsdkagde mdlegismda
      841 pgymsdgdvl sknirtddit sgymtdgglg lytrrlnrlp dgmavvretl qrntslglgd
      901 adswddsssv ssgisdtidn lstddintss sissyantpa ssrknldvqt daekhsqver
      961 nslwsgddvk ksdggsdsgi kmepgskwrr npsdvsdesd kstsgkknpv isqtgswrrg
     1021 mtaqvgitmp rtkasapaga lktpgtgktd dakvsekgrl spkasqvkrs psdagrssgd
     1081 eskkplpsss rtptanansf gfkkqsgsaa glamitasgv tvtsrsatlg kipkssalvs
     1141 rsagrkssmd gaqnqddgyl alssrtnlqy rslprpsksn srngagnrss tssidsniss
     1201 ksaglpvpkl repsktalgs slpglvnqtd kekgissdne svascnsvkv npaaqpvssp
     1261 aqtslqpgak ypdvasptlr rlfggkptkq vpiataenmk nsvvisnpha tmtqqgnlds
     1321 psgsgvlssg sssplysknv dlnqsplass pssahsapsn sltwgtnass ssavskdglg
     1381 fqsvsslhts cesidislss ggvpshnsst gliasskdds ltpfvrtnsv kttlsespls
     1441 spaaspkfcr stlprkqdsd phldrntlpk kglrytptsq lrtqedakew lrshsagglq
     1501 dtaanspfss gssvtspsgt rfnfsqlasp ttvtqmslsn ptmlrthsls nadgqydpyt
     1561 dsrfrnssms ldeksrtmsr sgsfrdgfee eswekssvdn fvsrlhsslh fslplfhhar
     1621 yelvhgssls lvsstssvys tpeekcqsei rklrreldas qekvsalttq ltanahlvaa
     1681 feqslgnmti rlqsltmtae qkdselnelr ktiellkkqn aaaqaaingv intpelnckg
     1741 ngtaqsadlr irrqhssdsv ssinsatshs svgsniesds kkkkrknwvn elrssfkqaf
     1801 gkkkspksas shsdieemtd sslpsspklp hngstgstpl lrnshsnsli secmdseaet
     1861 vmqlrnelrd kemkltdirl ealssahqld qlreamnrmq seieklkaen drlksesqgs
     1921 gcsrapsqvs isasprqsmg lsqhslnlte stsldmlldd tgecsarkeg grhvkivvsf
     1981 qeemkwkeds rphlfligci gvsgktkwdv ldgvvrrlfk eyiihvdpvs qlglnsdsvl
     2041 gysigeikrs ntsetpellp cgylvgentt isvtvkglae nsldslvfes lipkpilqry
     2101 vslliehrri ilsgpsgtgk tylanrlsey ivlregrelt dgviatfnvd hksskelrqy
     2161 lsnladqcns ennavdmplv iildnlhhvs slgeifngll nckyhkcpyi igtmnqatss
     2221 tpnlqlhhnf rwvlcanhte pvkgflgrfl rrklmeteis grvrnmelvk iidwipkvwh
     2281 hlnrfleahs ssdvtigprl flscpidvdg srvwftdlwn ysiipyllea ireglqlygr
     2341 rapwedpakw vmdtypwaas pqqhewppll qlrpedvgfd gysmpregst skqmppsdae
     2401 gdplmnmlmr lqeaanyssp qsydsdsnsn shhddildss lestl
//
LOCUS       XP_054226356            2443 aa            linear   PRI 05-AUG-2025
DEFINITION  neuron navigator 2 isoform X11 [Homo sapiens].
ACCESSION   XP_054226356
VERSION     XP_054226356.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370381.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2443
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2443
                     /product="neuron navigator 2 isoform X11"
                     /calculated_mol_wt=263163
     Region          77..190
                     /region_name="CH_NAV2"
                     /note="calponin homology (CH) domain found in neuron
                     navigator 2; cd21285"
                     /db_xref="CDD:409134"
     Site            order(87,91,145,147..148,151..152,154,163..171,176,
                     178..179,181..182,185..186,189)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409134"
     Region          <207..>394
                     /region_name="PRK07003"
                     /note="DNA polymerase III subunit gamma/tau"
                     /db_xref="CDD:235906"
     Region          <286..715
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          943..>1244
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          <1642..>1914
                     /region_name="Mplasa_alph_rch"
                     /note="helix-rich Mycoplasma protein; TIGR04523"
                     /db_xref="CDD:275316"
     Region          1642..>1718
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          <1861..>1916
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          1946..2330
                     /region_name="McrB"
                     /note="5-methylcytosine-specific restriction endonuclease
                     McrBC, GTP-binding regulatory subunit McrB [Defense
                     mechanisms]; COG1401"
                     /db_xref="CDD:441011"
     CDS             1..2443
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /coded_by="XM_054370381.1:860..8191"
                     /db_xref="GeneID:89797"
                     /db_xref="HGNC:HGNC:15997"
                     /db_xref="MIM:607026"
ORIGIN      
        1 mpailvaskm ksglpkpvhs aapilhvppa ragpqpcylk lgskvevskt typsqiplks
       61 qvlqglqepa geglplrksg svengfdtqi ytdwanhyla ksghkrlikd lqqdvtdgvl
      121 laqiiqvvan ekiedingcp knrsqmieni daclnflaak giniqglsae eirngnlkai
      181 lglffslsry kqqqqqpqkq hlssplppav sqvagapsqc qagtpqqqvp vtpqapcqph
      241 qpaphqqska qaemqsrlpg ptarvsaags eaktrggstt annrrsqsfn nydkskpvts
      301 pppppsshek eplassassh pgmsdnapas lesgssstpt ncstssaipq pgaatkpwrs
      361 kslsvkhsat vsmlsvkppg peaprptpea mkpapnnqks mleklklfns kggskagegp
      421 gsrdtscerl etlpsfeese eleaasrmlt tvgpassspk ialkgiaqrt fsraltnkks
      481 slkgnekeke kqqrekdkek skdlakrasv terldlkeep kedpsgaavp empkksskia
      541 sfipkggkln sakkepmaps hsgipkpgmk smpgkspsap apskegersr sgklssglpq
      601 qkpqldgrhs ssssslasse gkgpggttln hsissqtvsg svgttqttgs ntvsvqlpqp
      661 qqqynhpnta tvapflyrsq tdtegnvtae ssstgvsvep shftktgqpa leeltgedpe
      721 arrlrtvkni adlrqnleet msslrgtqvt hstlettfdt nvttemsgrs ilsltgrptp
      781 lswrlgqssp rlqagdapsm gngypprana srfintesgr yvysaplrrq lasrgssvch
      841 vdvsdkagde mdlegismda pgymsdgdvl sknirtddit sgymtdgglg lytrrlnrlp
      901 dgmavvretl qrntslglgd adswddsssv ssgisdtidn lstddintss sissyantpa
      961 ssrknldvqt daekhsqver nslwsgddvk ksdggsdsgi kmepgskwrr npsdvsdesd
     1021 kstsgkknpv isqtgswrrg mtaqvgitmp rtkasapaga lktpgtgktd dakvsekgrl
     1081 spkasqvkrs psdagrssgd eskkplpsss rtptanansf gfkkqsgsaa glamitasgv
     1141 tvtsrsatlg kipkssalvs rsagrkssmd gaqnqddgyl alssrtnlqy rslprpsksn
     1201 srngagnrss tssidsniss ksaglpvpkl repsktalgs slpglvnqtd kekgissdne
     1261 svascnsvkv npaaqpvssp aqtslqpgak ypdvasptlr rlfggkptkq vpiataenmk
     1321 nsvvisnpha tmtqqgnlds psgsgvlssg sssplysknv dlnqsplass pssahsapsn
     1381 sltwgtnass ssavskdglg fqsvsslhts cesidislss ggvpshnsst gliasskdds
     1441 ltpfvrtnsv kttlsesdph ldrntlpkkg lrytptsqlr tqedakewlr shsagglqdt
     1501 aanspfssgs svtspsgtrf nfsqlasptt vtqmslsnpt mlrthslsna dgqydpytds
     1561 rfrnssmsld eksrtmsrsg sfrdgfeees wekssvdnfv srlhsslhfs lplfhharye
     1621 lvhgsslslv sstssvystp eekcqseirk lrreldasqe kvsalttqlt anahlvaafe
     1681 qslgnmtirl qsltmtaeqk dselnelrkt iellkkqnaa aqaaingvin tpelnckgng
     1741 taqsadlrir rqhssdsvss insatshssv gsniesdskk kkrknwvnel rssfkqafgk
     1801 kkspksassh sdieemtdss lpsspklphn gstgstpllr nshsnslise cmdseaetvm
     1861 qlrnelrdke mkltdirlea lssahqldql reamnrmqse ieklkaendr lksesqgsgc
     1921 srapsqvsis asprqsmgls qhslnltest sldmllddtg ecsarkeggr hvkivvsfqe
     1981 emkwkedsrp hlfligcigv sgktkwdvld gvvrrlfkey iihvdpvsql glnsdsvlgy
     2041 sigeikrsnt setpellpcg ylvgenttis vtvkglaens ldslvfesli pkpilqryvs
     2101 lliehrriil sgpsgtgkty lanrlseyiv lregreltdg viatfnvdhk sskelrqyls
     2161 nladqcnsen navdmplvii ldnlhhvssl geifngllnc kyhkcpyiig tmnqatsstp
     2221 nlqlhhnfrw vlcanhtepv kgflgrflrr klmeteisgr vrnmelvkii dwipkvwhhl
     2281 nrfleahsss dvtigprlfl scpidvdgsr vwftdlwnys iipylleair eglqlygrra
     2341 pwedpakwvm dtypwaaspq qhewppllql rpedvgfdgy smpregstsk qmppsdaegd
     2401 plmnmlmrlq eaanysspqs ydsdsnsnsh hddildssle stl
//
LOCUS       XP_054226357            2440 aa            linear   PRI 05-AUG-2025
DEFINITION  neuron navigator 2 isoform X12 [Homo sapiens].
ACCESSION   XP_054226357
VERSION     XP_054226357.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370382.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2440
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2440
                     /product="neuron navigator 2 isoform X12"
                     /calculated_mol_wt=262821
     Region          77..190
                     /region_name="CH_NAV2"
                     /note="calponin homology (CH) domain found in neuron
                     navigator 2; cd21285"
                     /db_xref="CDD:409134"
     Site            order(87,91,145,147..148,151..152,154,163..171,176,
                     178..179,181..182,185..186,189)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409134"
     Region          <286..715
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          943..>1244
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          <1642..>1911
                     /region_name="Mplasa_alph_rch"
                     /note="helix-rich Mycoplasma protein; TIGR04523"
                     /db_xref="CDD:275316"
     Region          1642..>1718
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          <1858..>1913
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          1943..2327
                     /region_name="McrB"
                     /note="5-methylcytosine-specific restriction endonuclease
                     McrBC, GTP-binding regulatory subunit McrB [Defense
                     mechanisms]; COG1401"
                     /db_xref="CDD:441011"
     CDS             1..2440
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /coded_by="XM_054370382.1:860..8182"
                     /db_xref="GeneID:89797"
                     /db_xref="HGNC:HGNC:15997"
                     /db_xref="MIM:607026"
ORIGIN      
        1 mpailvaskm ksglpkpvhs aapilhvppa ragpqpcylk lgskvevskt typsqiplks
       61 qvlqglqepa geglplrksg svengfdtqi ytdwanhyla ksghkrlikd lqqdvtdgvl
      121 laqiiqvvan ekiedingcp knrsqmieni daclnflaak giniqglsae eirngnlkai
      181 lglffslsry kqqqqqpqkq hlssplppav sqvagapsqc qagtpqqqvp vtpqapcqph
      241 qpaphqqska qaemqsrlpg ptarvsaags eaktrggstt annrrsqsfn nydkskpvts
      301 pppppsshek eplassassh pgmsdnapas lesgssstpt ncstssaipq pgaatkpwrs
      361 kslsvkhsat vsmlsvkppg peaprptpea mkpapnnqks mleklklfns kggskagegp
      421 gsrdtscerl etlpsfeese eleaasrmlt tvgpassspk ialkgiaqrt fsraltnkks
      481 slkgnekeke kqqrekdkek skdlakrasv terldlkeep kedpsgaavp empkksskia
      541 sfipkggkln sakkepmaps hsgipkpgmk smpgkspsap apskegersr sgklssglpq
      601 qkpqldgrhs ssssslasse gkgpggttln hsissqtvsg svgttqttgs ntvsvqlpqp
      661 qqqynhpnta tvapflyrsq tdtegnvtae ssstgvsvep shftktgqpa leeltgedpe
      721 arrlrtvkni adlrqnleet msslrgtqvt hstlettfdt nvttemsgrs ilsltgrptp
      781 lswrlgqssp rlqagdapsm gngypprana srfintesgr yvysaplrrq lasrgssvch
      841 vdvsdkagde mdlegismda pgymsdgdvl sknirtddit sgymtdgglg lytrrlnrlp
      901 dgmavvretl qrntslglgd adswddsssv ssgisdtidn lstddintss sissyantpa
      961 ssrknldvqt daekhsqver nslwsgddvk ksdggsdsgi kmepgskwrr npsdvsdesd
     1021 kstsgkknpv isqtgswrrg mtaqvgitmp rtkasapaga lktpgtgktd dakvsekgrl
     1081 spkasqvkrs psdagrssgd eskkplpsss rtptanansf gfkkqsgsaa glamitasgv
     1141 tvtsrsatlg kipkssalvs rsagrkssmd gaqnqddgyl alssrtnlqy rslprpsksn
     1201 srngagnrss tssidsniss ksaglpvpkl repsktalgs slpglvnqtd kekgissdne
     1261 svascnsvkv npaaqpvssp aqtslqpgak ypdvasptlr rlfggkptkq vpiataenmk
     1321 nsvvisnpha tmtqqgnlds psgsgvlssg sssplysknv dlnqsplass pssahsapsn
     1381 sltwgtnass ssavskdglg fqsvsslhts cesidislss ggvpshnsst gliasskdds
     1441 ltpfvrtnsv kttlsesdph ldrntlpkkg lrytptsqlr tqedakewlr shsagglqdt
     1501 aanspfssgs svtspsgtrf nfsqlasptt vtqmslsnpt mlrthslsna dgqydpytds
     1561 rfrnssmsld eksrtmsrsg sfrdgfeees wekssvdnfv srlhsslhfs lplfhharye
     1621 lvhgsslslv sstssvystp eekcqseirk lrreldasqe kvsalttqlt anahlvaafe
     1681 qslgnmtirl qsltmtaeqk dselnelrkt iellkkqnaa aqaaingvin tpelnckgng
     1741 taqsadlrir rqhssdsvss insatshssv gsniesdskk kkrknwlrss fkqafgkkks
     1801 pksasshsdi eemtdsslps spklphngst gstpllrnsh snslisecmd seaetvmqlr
     1861 nelrdkemkl tdirlealss ahqldqlrea mnrmqseiek lkaendrlks esqgsgcsra
     1921 psqvsisasp rqsmglsqhs lnltestsld mllddtgecs arkeggrhvk ivvsfqeemk
     1981 wkedsrphlf ligcigvsgk tkwdvldgvv rrlfkeyiih vdpvsqlgln sdsvlgysig
     2041 eikrsntset pellpcgylv genttisvtv kglaenslds lvfeslipkp ilqryvslli
     2101 ehrriilsgp sgtgktylan rlseyivlre greltdgvia tfnvdhkssk elrqylsnla
     2161 dqcnsennav dmplviildn lhhvsslgei fngllnckyh kcpyiigtmn qatsstpnlq
     2221 lhhnfrwvlc anhtepvkgf lgrflrrklm eteisgrvrn melvkiidwi pkvwhhlnrf
     2281 leahsssdvt igprlflscp idvdgsrvwf tdlwnysiip ylleairegl qlygrrapwe
     2341 dpakwvmdty pwaaspqqhe wppllqlrpe dvgfdgysmp regstskqmp psdaegdplm
     2401 nmlmrlqeaa nysspqsyds dsnsnshhdd ildsslestl
//
LOCUS       XP_054226358            2433 aa            linear   PRI 05-AUG-2025
DEFINITION  neuron navigator 2 isoform X13 [Homo sapiens].
ACCESSION   XP_054226358
VERSION     XP_054226358.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370383.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2433
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2433
                     /product="neuron navigator 2 isoform X13"
                     /calculated_mol_wt=261703
     Region          77..190
                     /region_name="CH_NAV2"
                     /note="calponin homology (CH) domain found in neuron
                     navigator 2; cd21285"
                     /db_xref="CDD:409134"
     Site            order(87,91,145,147..148,151..152,154,163..171,176,
                     178..179,181..182,185..186,189)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409134"
     Region          <309..738
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          966..>1267
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          <1632..>1904
                     /region_name="Mplasa_alph_rch"
                     /note="helix-rich Mycoplasma protein; TIGR04523"
                     /db_xref="CDD:275316"
     Region          1632..>1708
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          1843..>1901
                     /region_name="Atg16_CCD"
                     /note="Coiled-coiled domain of autophagy-related 16
                     (Atg16) family proteins; cl46300"
                     /db_xref="CDD:480640"
     Region          1936..2320
                     /region_name="McrB"
                     /note="5-methylcytosine-specific restriction endonuclease
                     McrBC, GTP-binding regulatory subunit McrB [Defense
                     mechanisms]; COG1401"
                     /db_xref="CDD:441011"
     CDS             1..2433
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /coded_by="XM_054370383.1:860..8161"
                     /db_xref="GeneID:89797"
                     /db_xref="HGNC:HGNC:15997"
                     /db_xref="MIM:607026"
ORIGIN      
        1 mpailvaskm ksglpkpvhs aapilhvppa ragpqpcylk lgskvevskt typsqiplks
       61 qvlqglqepa geglplrksg svengfdtqi ytdwanhyla ksghkrlikd lqqdvtdgvl
      121 laqiiqvvan ekiedingcp knrsqmieni daclnflaak giniqglsae eirngnlkai
      181 lglffslsry kqqqqqpqkq hlssplppav sqvagapsqc qagtpqqqvp vtpqapcqph
      241 qpaphqqska qaemqssass kdssqskiir ftlgqkkisr lpgptarvsa agseaktrgg
      301 sttannrrsq sfnnydkskp vtspppppss hekeplassa sshpgmsdna paslesgsss
      361 tptncstssa ipqpgaatkp wrskslsvkh satvsmlsvk ppgpeaprpt peamkpapnn
      421 qksmleklkl fnskggskag egpgsrdtsc erletlpsfe eseeleaasr mlttvgpass
      481 spkialkgia qrtfsraltn kksslkgnek ekekqqrekd kekskdlakr asvterldlk
      541 eepkedpsga avpempkkss kiasfipkgg klnsakkepm apshsgipkp gmksmpgksp
      601 sapapskege rsrsgklssg lpqqkpqldg rhssssssla ssegkgpggt tlnhsissqt
      661 vsgsvgttqt tgsntvsvql pqpqqqynhp ntatvapfly rsqtdtegnv taessstgvs
      721 vepshftktg qpaleeltge dpearrlrtv kniadlrqnl eetmsslrgt qvthstlett
      781 fdtnvttems grsilsltgr ptplswrlgq ssprlqagda psmgngyppr anasrfinte
      841 sgryvysapl rrqlasrgss vchvdvsdka gdemdlegis mdapgymsdg dvlsknirtd
      901 ditsgymtdg glglytrrln rlpdgmavvr etlqrntslg lgdadswdds ssvssgisdt
      961 idnlstddin tsssissyan tpassrknld vqtdaekhsq vernslwsgd dvkksdggsd
     1021 sgikmepgsk wrrnpsdvsd esdkstsgkk npvisqtgsw rrgmtaqvgi tmprtkasap
     1081 agalktpgtg ktddakvsek grlspkasqv krspsdagrs sgdeskkplp sssrtptana
     1141 nsfgfkkqsg saaglamita sgvtvtsrsa tlgkipkssa lvsrsagrks smdgaqnqdd
     1201 gylalssrtn lqyrslprps ksnsrngagn rsstssidsn issksaglpv pklrepskta
     1261 lgsslpglvn qtdkekgiss dnesvascns vkvnpaaqpv sspaqtslqp gakypdvasp
     1321 tlrrlfggkp tkqvpiatae nmknsvvisn phatmtqqgn ldspsgsgvl ssgsssplys
     1381 knvdlnqspl asspssahsa psnsltwgtn assssavskd glgfqsvssl htscesidis
     1441 lssggvpshn sstgliassk ddsltpfvrt nsvkttlses dphldrntlp kkglrytpts
     1501 qlrtqedake wlrshsaggl qdtaanspfs sgssvtspsg trfnfsqlas pttvtqmsls
     1561 nptmlrthsl snadgqydpy tdsrfrnssm sldeksrtms rsgsfrdgfe evhgsslslv
     1621 sstssvystp eekcqseirk lrreldasqe kvsalttqlt anahlvaafe qslgnmtirl
     1681 qsltmtaeqk dselnelrkt iellkkqnaa aqaaingvin tpelnckgng taqsadlrir
     1741 rqhssdsvss insatshssv gsniesdskk kkrknwvnel rssfkqafgk kkspksassh
     1801 sdieemtdss lpsspklphn gstgstpllr nshsnslise cmdseaetvm qlrnelrdke
     1861 mkltdirlea lssahqldql reamnrmqse ieklkaendr lksesqgsgc srapsqvsis
     1921 asprqsmgls qhslnltest sldmllddtg ecsarkeggr hvkivvsfqe emkwkedsrp
     1981 hlfligcigv sgktkwdvld gvvrrlfkey iihvdpvsql glnsdsvlgy sigeikrsnt
     2041 setpellpcg ylvgenttis vtvkglaens ldslvfesli pkpilqryvs lliehrriil
     2101 sgpsgtgkty lanrlseyiv lregreltdg viatfnvdhk sskelrqyls nladqcnsen
     2161 navdmplvii ldnlhhvssl geifngllnc kyhkcpyiig tmnqatsstp nlqlhhnfrw
     2221 vlcanhtepv kgflgrflrr klmeteisgr vrnmelvkii dwipkvwhhl nrfleahsss
     2281 dvtigprlfl scpidvdgsr vwftdlwnys iipylleair eglqlygrra pwedpakwvm
     2341 dtypwaaspq qhewppllql rpedvgfdgy smpregstsk qmppsdaegd plmnmlmrlq
     2401 eaanysspqs ydsdsnsnsh hddildssle stl
//
LOCUS       XP_054226359            2430 aa            linear   PRI 05-AUG-2025
DEFINITION  neuron navigator 2 isoform X14 [Homo sapiens].
ACCESSION   XP_054226359
VERSION     XP_054226359.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370384.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2430
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2430
                     /product="neuron navigator 2 isoform X14"
                     /calculated_mol_wt=261361
     Region          77..190
                     /region_name="CH_NAV2"
                     /note="calponin homology (CH) domain found in neuron
                     navigator 2; cd21285"
                     /db_xref="CDD:409134"
     Site            order(87,91,145,147..148,151..152,154,163..171,176,
                     178..179,181..182,185..186,189)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409134"
     Region          <309..738
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          966..>1267
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          1632..>1708
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          1840..>1898
                     /region_name="Atg16_CCD"
                     /note="Coiled-coiled domain of autophagy-related 16
                     (Atg16) family proteins; cl46300"
                     /db_xref="CDD:480640"
     Region          1933..2317
                     /region_name="McrB"
                     /note="5-methylcytosine-specific restriction endonuclease
                     McrBC, GTP-binding regulatory subunit McrB [Defense
                     mechanisms]; COG1401"
                     /db_xref="CDD:441011"
     CDS             1..2430
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /coded_by="XM_054370384.1:860..8152"
                     /db_xref="GeneID:89797"
                     /db_xref="HGNC:HGNC:15997"
                     /db_xref="MIM:607026"
ORIGIN      
        1 mpailvaskm ksglpkpvhs aapilhvppa ragpqpcylk lgskvevskt typsqiplks
       61 qvlqglqepa geglplrksg svengfdtqi ytdwanhyla ksghkrlikd lqqdvtdgvl
      121 laqiiqvvan ekiedingcp knrsqmieni daclnflaak giniqglsae eirngnlkai
      181 lglffslsry kqqqqqpqkq hlssplppav sqvagapsqc qagtpqqqvp vtpqapcqph
      241 qpaphqqska qaemqssass kdssqskiir ftlgqkkisr lpgptarvsa agseaktrgg
      301 sttannrrsq sfnnydkskp vtspppppss hekeplassa sshpgmsdna paslesgsss
      361 tptncstssa ipqpgaatkp wrskslsvkh satvsmlsvk ppgpeaprpt peamkpapnn
      421 qksmleklkl fnskggskag egpgsrdtsc erletlpsfe eseeleaasr mlttvgpass
      481 spkialkgia qrtfsraltn kksslkgnek ekekqqrekd kekskdlakr asvterldlk
      541 eepkedpsga avpempkkss kiasfipkgg klnsakkepm apshsgipkp gmksmpgksp
      601 sapapskege rsrsgklssg lpqqkpqldg rhssssssla ssegkgpggt tlnhsissqt
      661 vsgsvgttqt tgsntvsvql pqpqqqynhp ntatvapfly rsqtdtegnv taessstgvs
      721 vepshftktg qpaleeltge dpearrlrtv kniadlrqnl eetmsslrgt qvthstlett
      781 fdtnvttems grsilsltgr ptplswrlgq ssprlqagda psmgngyppr anasrfinte
      841 sgryvysapl rrqlasrgss vchvdvsdka gdemdlegis mdapgymsdg dvlsknirtd
      901 ditsgymtdg glglytrrln rlpdgmavvr etlqrntslg lgdadswdds ssvssgisdt
      961 idnlstddin tsssissyan tpassrknld vqtdaekhsq vernslwsgd dvkksdggsd
     1021 sgikmepgsk wrrnpsdvsd esdkstsgkk npvisqtgsw rrgmtaqvgi tmprtkasap
     1081 agalktpgtg ktddakvsek grlspkasqv krspsdagrs sgdeskkplp sssrtptana
     1141 nsfgfkkqsg saaglamita sgvtvtsrsa tlgkipkssa lvsrsagrks smdgaqnqdd
     1201 gylalssrtn lqyrslprps ksnsrngagn rsstssidsn issksaglpv pklrepskta
     1261 lgsslpglvn qtdkekgiss dnesvascns vkvnpaaqpv sspaqtslqp gakypdvasp
     1321 tlrrlfggkp tkqvpiatae nmknsvvisn phatmtqqgn ldspsgsgvl ssgsssplys
     1381 knvdlnqspl asspssahsa psnsltwgtn assssavskd glgfqsvssl htscesidis
     1441 lssggvpshn sstgliassk ddsltpfvrt nsvkttlses dphldrntlp kkglrytpts
     1501 qlrtqedake wlrshsaggl qdtaanspfs sgssvtspsg trfnfsqlas pttvtqmsls
     1561 nptmlrthsl snadgqydpy tdsrfrnssm sldeksrtms rsgsfrdgfe evhgsslslv
     1621 sstssvystp eekcqseirk lrreldasqe kvsalttqlt anahlvaafe qslgnmtirl
     1681 qsltmtaeqk dselnelrkt iellkkqnaa aqaaingvin tpelnckgng taqsadlrir
     1741 rqhssdsvss insatshssv gsniesdskk kkrknwlrss fkqafgkkks pksasshsdi
     1801 eemtdsslps spklphngst gstpllrnsh snslisecmd seaetvmqlr nelrdkemkl
     1861 tdirlealss ahqldqlrea mnrmqseiek lkaendrlks esqgsgcsra psqvsisasp
     1921 rqsmglsqhs lnltestsld mllddtgecs arkeggrhvk ivvsfqeemk wkedsrphlf
     1981 ligcigvsgk tkwdvldgvv rrlfkeyiih vdpvsqlgln sdsvlgysig eikrsntset
     2041 pellpcgylv genttisvtv kglaenslds lvfeslipkp ilqryvslli ehrriilsgp
     2101 sgtgktylan rlseyivlre greltdgvia tfnvdhkssk elrqylsnla dqcnsennav
     2161 dmplviildn lhhvsslgei fngllnckyh kcpyiigtmn qatsstpnlq lhhnfrwvlc
     2221 anhtepvkgf lgrflrrklm eteisgrvrn melvkiidwi pkvwhhlnrf leahsssdvt
     2281 igprlflscp idvdgsrvwf tdlwnysiip ylleairegl qlygrrapwe dpakwvmdty
     2341 pwaaspqqhe wppllqlrpe dvgfdgysmp regstskqmp psdaegdplm nmlmrlqeaa
     2401 nysspqsyds dsnsnshhdd ildsslestl
//
LOCUS       XP_054226360            2428 aa            linear   PRI 05-AUG-2025
DEFINITION  neuron navigator 2 isoform X15 [Homo sapiens].
ACCESSION   XP_054226360
VERSION     XP_054226360.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370385.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2428
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2428
                     /product="neuron navigator 2 isoform X15"
                     /calculated_mol_wt=261490
     Region          77..190
                     /region_name="CH_NAV2"
                     /note="calponin homology (CH) domain found in neuron
                     navigator 2; cd21285"
                     /db_xref="CDD:409134"
     Site            order(87,91,145,147..148,151..152,154,163..171,176,
                     178..179,181..182,185..186,189)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409134"
     Region          <207..>394
                     /region_name="PRK07003"
                     /note="DNA polymerase III subunit gamma/tau"
                     /db_xref="CDD:235906"
     Region          <286..715
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          943..>1244
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          <1627..>1899
                     /region_name="Mplasa_alph_rch"
                     /note="helix-rich Mycoplasma protein; TIGR04523"
                     /db_xref="CDD:275316"
     Region          1627..>1703
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          <1846..>1901
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          1931..2315
                     /region_name="McrB"
                     /note="5-methylcytosine-specific restriction endonuclease
                     McrBC, GTP-binding regulatory subunit McrB [Defense
                     mechanisms]; COG1401"
                     /db_xref="CDD:441011"
     CDS             1..2428
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /coded_by="XM_054370385.1:860..8146"
                     /db_xref="GeneID:89797"
                     /db_xref="HGNC:HGNC:15997"
                     /db_xref="MIM:607026"
ORIGIN      
        1 mpailvaskm ksglpkpvhs aapilhvppa ragpqpcylk lgskvevskt typsqiplks
       61 qvlqglqepa geglplrksg svengfdtqi ytdwanhyla ksghkrlikd lqqdvtdgvl
      121 laqiiqvvan ekiedingcp knrsqmieni daclnflaak giniqglsae eirngnlkai
      181 lglffslsry kqqqqqpqkq hlssplppav sqvagapsqc qagtpqqqvp vtpqapcqph
      241 qpaphqqska qaemqsrlpg ptarvsaags eaktrggstt annrrsqsfn nydkskpvts
      301 pppppsshek eplassassh pgmsdnapas lesgssstpt ncstssaipq pgaatkpwrs
      361 kslsvkhsat vsmlsvkppg peaprptpea mkpapnnqks mleklklfns kggskagegp
      421 gsrdtscerl etlpsfeese eleaasrmlt tvgpassspk ialkgiaqrt fsraltnkks
      481 slkgnekeke kqqrekdkek skdlakrasv terldlkeep kedpsgaavp empkksskia
      541 sfipkggkln sakkepmaps hsgipkpgmk smpgkspsap apskegersr sgklssglpq
      601 qkpqldgrhs ssssslasse gkgpggttln hsissqtvsg svgttqttgs ntvsvqlpqp
      661 qqqynhpnta tvapflyrsq tdtegnvtae ssstgvsvep shftktgqpa leeltgedpe
      721 arrlrtvkni adlrqnleet msslrgtqvt hstlettfdt nvttemsgrs ilsltgrptp
      781 lswrlgqssp rlqagdapsm gngypprana srfintesgr yvysaplrrq lasrgssvch
      841 vdvsdkagde mdlegismda pgymsdgdvl sknirtddit sgymtdgglg lytrrlnrlp
      901 dgmavvretl qrntslglgd adswddsssv ssgisdtidn lstddintss sissyantpa
      961 ssrknldvqt daekhsqver nslwsgddvk ksdggsdsgi kmepgskwrr npsdvsdesd
     1021 kstsgkknpv isqtgswrrg mtaqvgitmp rtkasapaga lktpgtgktd dakvsekgrl
     1081 spkasqvkrs psdagrssgd eskkplpsss rtptanansf gfkkqsgsaa glamitasgv
     1141 tvtsrsatlg kipkssalvs rsagrkssmd gaqnqddgyl alssrtnlqy rslprpsksn
     1201 srngagnrss tssidsniss ksaglpvpkl repsktalgs slpglvnqtd kekgissdne
     1261 svascnsvkv npaaqpvssp aqtslqpgak ypdvasptlr rlfggkptkq vpiataenmk
     1321 nsvvisnpha tmtqqgnlds psgsgvlssg sssplysknv dlnqsplass pssahsapsn
     1381 sltwgtnass ssavskdglg fqsvsslhts cesidislss ggvpshnsst gliasskdds
     1441 ltpfvrtnsv kttlserytp tsqlrtqeda kewlrshsag glqdtaansp fssgssvtsp
     1501 sgtrfnfsql aspttvtqms lsnptmlrth slsnadgqyd pytdsrfrns smsldeksrt
     1561 msrsgsfrdg feeeswekss vdnfvsrlhs slhfslplfh haryelvhgs slslvsstss
     1621 vystpeekcq seirklrrel dasqekvsal ttqltanahl vaafeqslgn mtirlqsltm
     1681 taeqkdseln elrktiellk kqnaaaqaai ngvintpeln ckgngtaqsa dlrirrqhss
     1741 dsvssinsat shssvgsnie sdskkkkrkn wvnelrssfk qafgkkkspk sasshsdiee
     1801 mtdsslpssp klphngstgs tpllrnshsn slisecmdse aetvmqlrne lrdkemkltd
     1861 irlealssah qldqlreamn rmqseieklk aendrlkses qgsgcsraps qvsisasprq
     1921 smglsqhsln ltestsldml lddtgecsar keggrhvkiv vsfqeemkwk edsrphlfli
     1981 gcigvsgktk wdvldgvvrr lfkeyiihvd pvsqlglnsd svlgysigei krsntsetpe
     2041 llpcgylvge nttisvtvkg laensldslv feslipkpil qryvsllieh rriilsgpsg
     2101 tgktylanrl seyivlregr eltdgviatf nvdhksskel rqylsnladq cnsennavdm
     2161 plviildnlh hvsslgeifn gllnckyhkc pyiigtmnqa tsstpnlqlh hnfrwvlcan
     2221 htepvkgflg rflrrklmet eisgrvrnme lvkiidwipk vwhhlnrfle ahsssdvtig
     2281 prlflscpid vdgsrvwftd lwnysiipyl leaireglql ygrrapwedp akwvmdtypw
     2341 aaspqqhewp pllqlrpedv gfdgysmpre gstskqmpps daegdplmnm lmrlqeaany
     2401 sspqsydsds nsnshhddil dsslestl
//
LOCUS       XP_054226361            2425 aa            linear   PRI 05-AUG-2025
DEFINITION  neuron navigator 2 isoform X16 [Homo sapiens].
ACCESSION   XP_054226361
VERSION     XP_054226361.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370386.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2425
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2425
                     /product="neuron navigator 2 isoform X16"
                     /calculated_mol_wt=261148
     Region          77..190
                     /region_name="CH_NAV2"
                     /note="calponin homology (CH) domain found in neuron
                     navigator 2; cd21285"
                     /db_xref="CDD:409134"
     Site            order(87,91,145,147..148,151..152,154,163..171,176,
                     178..179,181..182,185..186,189)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409134"
     Region          <286..715
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          943..>1244
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          1627..>1703
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          1835..>1893
                     /region_name="Atg16_CCD"
                     /note="Coiled-coiled domain of autophagy-related 16
                     (Atg16) family proteins; cl46300"
                     /db_xref="CDD:480640"
     Region          1928..2312
                     /region_name="McrB"
                     /note="5-methylcytosine-specific restriction endonuclease
                     McrBC, GTP-binding regulatory subunit McrB [Defense
                     mechanisms]; COG1401"
                     /db_xref="CDD:441011"
     CDS             1..2425
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /coded_by="XM_054370386.1:860..8137"
                     /db_xref="GeneID:89797"
                     /db_xref="HGNC:HGNC:15997"
                     /db_xref="MIM:607026"
ORIGIN      
        1 mpailvaskm ksglpkpvhs aapilhvppa ragpqpcylk lgskvevskt typsqiplks
       61 qvlqglqepa geglplrksg svengfdtqi ytdwanhyla ksghkrlikd lqqdvtdgvl
      121 laqiiqvvan ekiedingcp knrsqmieni daclnflaak giniqglsae eirngnlkai
      181 lglffslsry kqqqqqpqkq hlssplppav sqvagapsqc qagtpqqqvp vtpqapcqph
      241 qpaphqqska qaemqsrlpg ptarvsaags eaktrggstt annrrsqsfn nydkskpvts
      301 pppppsshek eplassassh pgmsdnapas lesgssstpt ncstssaipq pgaatkpwrs
      361 kslsvkhsat vsmlsvkppg peaprptpea mkpapnnqks mleklklfns kggskagegp
      421 gsrdtscerl etlpsfeese eleaasrmlt tvgpassspk ialkgiaqrt fsraltnkks
      481 slkgnekeke kqqrekdkek skdlakrasv terldlkeep kedpsgaavp empkksskia
      541 sfipkggkln sakkepmaps hsgipkpgmk smpgkspsap apskegersr sgklssglpq
      601 qkpqldgrhs ssssslasse gkgpggttln hsissqtvsg svgttqttgs ntvsvqlpqp
      661 qqqynhpnta tvapflyrsq tdtegnvtae ssstgvsvep shftktgqpa leeltgedpe
      721 arrlrtvkni adlrqnleet msslrgtqvt hstlettfdt nvttemsgrs ilsltgrptp
      781 lswrlgqssp rlqagdapsm gngypprana srfintesgr yvysaplrrq lasrgssvch
      841 vdvsdkagde mdlegismda pgymsdgdvl sknirtddit sgymtdgglg lytrrlnrlp
      901 dgmavvretl qrntslglgd adswddsssv ssgisdtidn lstddintss sissyantpa
      961 ssrknldvqt daekhsqver nslwsgddvk ksdggsdsgi kmepgskwrr npsdvsdesd
     1021 kstsgkknpv isqtgswrrg mtaqvgitmp rtkasapaga lktpgtgktd dakvsekgrl
     1081 spkasqvkrs psdagrssgd eskkplpsss rtptanansf gfkkqsgsaa glamitasgv
     1141 tvtsrsatlg kipkssalvs rsagrkssmd gaqnqddgyl alssrtnlqy rslprpsksn
     1201 srngagnrss tssidsniss ksaglpvpkl repsktalgs slpglvnqtd kekgissdne
     1261 svascnsvkv npaaqpvssp aqtslqpgak ypdvasptlr rlfggkptkq vpiataenmk
     1321 nsvvisnpha tmtqqgnlds psgsgvlssg sssplysknv dlnqsplass pssahsapsn
     1381 sltwgtnass ssavskdglg fqsvsslhts cesidislss ggvpshnsst gliasskdds
     1441 ltpfvrtnsv kttlserytp tsqlrtqeda kewlrshsag glqdtaansp fssgssvtsp
     1501 sgtrfnfsql aspttvtqms lsnptmlrth slsnadgqyd pytdsrfrns smsldeksrt
     1561 msrsgsfrdg feeeswekss vdnfvsrlhs slhfslplfh haryelvhgs slslvsstss
     1621 vystpeekcq seirklrrel dasqekvsal ttqltanahl vaafeqslgn mtirlqsltm
     1681 taeqkdseln elrktiellk kqnaaaqaai ngvintpeln ckgngtaqsa dlrirrqhss
     1741 dsvssinsat shssvgsnie sdskkkkrkn wlrssfkqaf gkkkspksas shsdieemtd
     1801 sslpsspklp hngstgstpl lrnshsnsli secmdseaet vmqlrnelrd kemkltdirl
     1861 ealssahqld qlreamnrmq seieklkaen drlksesqgs gcsrapsqvs isasprqsmg
     1921 lsqhslnlte stsldmlldd tgecsarkeg grhvkivvsf qeemkwkeds rphlfligci
     1981 gvsgktkwdv ldgvvrrlfk eyiihvdpvs qlglnsdsvl gysigeikrs ntsetpellp
     2041 cgylvgentt isvtvkglae nsldslvfes lipkpilqry vslliehrri ilsgpsgtgk
     2101 tylanrlsey ivlregrelt dgviatfnvd hksskelrqy lsnladqcns ennavdmplv
     2161 iildnlhhvs slgeifngll nckyhkcpyi igtmnqatss tpnlqlhhnf rwvlcanhte
     2221 pvkgflgrfl rrklmeteis grvrnmelvk iidwipkvwh hlnrfleahs ssdvtigprl
     2281 flscpidvdg srvwftdlwn ysiipyllea ireglqlygr rapwedpakw vmdtypwaas
     2341 pqqhewppll qlrpedvgfd gysmpregst skqmppsdae gdplmnmlmr lqeaanyssp
     2401 qsydsdsnsn shhddildss lestl
//
LOCUS       XP_054226362            2424 aa            linear   PRI 05-AUG-2025
DEFINITION  neuron navigator 2 isoform X17 [Homo sapiens].
ACCESSION   XP_054226362
VERSION     XP_054226362.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370387.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2424
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2424
                     /product="neuron navigator 2 isoform X17"
                     /calculated_mol_wt=261568
     Region          15..126
                     /region_name="CH_NAV2"
                     /note="calponin homology (CH) domain found in neuron
                     navigator 2; cd21285"
                     /db_xref="CDD:409134"
     Site            order(23,27,81,83..84,87..88,90,99..107,112,114..115,
                     117..118,121..122,125)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409134"
     Region          <245..674
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          902..>1203
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          <1623..>1895
                     /region_name="Mplasa_alph_rch"
                     /note="helix-rich Mycoplasma protein; TIGR04523"
                     /db_xref="CDD:275316"
     Region          1623..>1699
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          1834..>1892
                     /region_name="Atg16_CCD"
                     /note="Coiled-coiled domain of autophagy-related 16
                     (Atg16) family proteins; cl46300"
                     /db_xref="CDD:480640"
     Region          1927..2311
                     /region_name="McrB"
                     /note="5-methylcytosine-specific restriction endonuclease
                     McrBC, GTP-binding regulatory subunit McrB [Defense
                     mechanisms]; COG1401"
                     /db_xref="CDD:441011"
     CDS             1..2424
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /coded_by="XM_054370387.1:657..7931"
                     /db_xref="GeneID:89797"
                     /db_xref="HGNC:HGNC:15997"
                     /db_xref="MIM:607026"
ORIGIN      
        1 mesvsessqq qkrkpvihgl edqkriytdw anhylaksgh krlikdlqqd vtdgvllaqi
       61 iqvvanekie dingcpknrs qmienidacl nflaakgini qglsaeeirn gnlkailglf
      121 fslsrykqqq qqpqkqhlss plppavsqva gapsqcqagt pqqqvpvtpq apcqphqpap
      181 hqqskaqaem qssasskdss qskiirftlg qkkisrlpgp tarvsaagse aktrggstta
      241 nnrrsqsfnn ydkskpvtsp ppppssheke plassasshp gmsdnapasl esgssstptn
      301 cstssaipqp gaatkpwrsk slsvkhsatv smlsvkppgp eaprptpeam kpapnnqksm
      361 leklklfnsk ggskagegpg srdtscerle tlpsfeesee leaasrmltt vgpassspki
      421 alkgiaqrtf sraltnkkss lkgnekekek qqrekdkeks kdlakrasvt erldlkeepk
      481 edpsgaavpe mpkksskias fipkggklns akkepmapsh sgipkpgmks mpgkspsapa
      541 pskegersrs gklssglpqq kpqldgrhss sssslasseg kgpggttlnh sissqtvsgs
      601 vgttqttgsn tvsvqlpqpq qqynhpntat vapflyrsqt dtegnvtaes sstgvsveps
      661 hftktgqpal eeltgedpea rrlrtvknia dlrqnleetm sslrgtqvth stlettfdtn
      721 vttemsgrsi lsltgrptpl swrlgqsspr lqagdapsmg ngyppranas rfintesgry
      781 vysaplrrql asrgssvchv dvsdkagdem dlegismdap gymsdgdvls knirtddits
      841 gymtdgglgl ytrrlnrlpd gmavvretlq rntslglgda dswddsssvs sgisdtidnl
      901 stddintsss issyantpas srknldvqtd aekhsqvern slwsgddvkk sdggsdsgik
      961 mepgskwrrn psdvsdesdk stsgkknpvi sqtgswrrgm taqvgitmpr tkasapagal
     1021 ktpgtgktdd akvsekgrls pkasqvkrsp sdagrssgde skkplpsssr tptanansfg
     1081 fkkqsgsaag lamitasgvt vtsrsatlgk ipkssalvsr sagrkssmdg aqnqddgyla
     1141 lssrtnlqyr slprpsksns rngagnrsst ssidsnissk saglpvpklr epsktalgss
     1201 lpglvnqtdk ekgissdnes vascnsvkvn paaqpvsspa qtslqpgaky pdvasptlrr
     1261 lfggkptkqv piataenmkn svvisnphat mtqqgnldsp sgsgvlssgs ssplysknvd
     1321 lnqsplassp ssahsapsns ltwgtnasss savskdglgf qsvsslhtsc esidislssg
     1381 gvpshnsstg liasskddsl tpfvrtnsvk ttlsesplss paaspkfcrs tlprkqdsdp
     1441 hldrntlpkk glrytptsql rtqedakewl rshsagglqd taanspfssg ssvtspsgtr
     1501 fnfsqlaspt tvtqmslsnp tmlrthslsn adgqydpytd srfrnssmsl deksrtmsrs
     1561 gsfrdgfeee swekssvdnf vsrlhsslhf slplfhhary elvhgsslsl vsstssvyst
     1621 peekcqseir klrreldasq ekvsalttql tanahlvaaf eqslgnmtir lqsltmtaeq
     1681 kdselnelrk tiellkkqna aaqaaingvi ntpelnckgn gtaqsadlri rrqhssdsvs
     1741 sinsatshss vgsniesdsk kkkrknwvne lrssfkqafg kkkspksass hsdieemtds
     1801 slpsspklph ngstgstpll rnshsnslis ecmdseaetv mqlrnelrdk emkltdirle
     1861 alssahqldq lreamnrmqs eieklkaend rlksesqgsg csrapsqvsi sasprqsmgl
     1921 sqhslnltes tsldmllddt gecsarkegg rhvkivvsfq eemkwkedsr phlfligcig
     1981 vsgktkwdvl dgvvrrlfke yiihvdpvsq lglnsdsvlg ysigeikrsn tsetpellpc
     2041 gylvgentti svtvkglaen sldslvfesl ipkpilqryv slliehrrii lsgpsgtgkt
     2101 ylanrlseyi vlregreltd gviatfnvdh ksskelrqyl snladqcnse nnavdmplvi
     2161 ildnlhhvss lgeifnglln ckyhkcpyii gtmnqatsst pnlqlhhnfr wvlcanhtep
     2221 vkgflgrflr rklmeteisg rvrnmelvki idwipkvwhh lnrfleahss sdvtigprlf
     2281 lscpidvdgs rvwftdlwny siipylleai reglqlygrr apwedpakwv mdtypwaasp
     2341 qqhewppllq lrpedvgfdg ysmpregsts kqmppsdaeg dplmnmlmrl qeaanysspq
     2401 sydsdsnsns hhddildssl estl
//
LOCUS       XP_054226363            2422 aa            linear   PRI 05-AUG-2025
DEFINITION  neuron navigator 2 isoform X18 [Homo sapiens].
ACCESSION   XP_054226363
VERSION     XP_054226363.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370388.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2422
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2422
                     /product="neuron navigator 2 isoform X18"
                     /calculated_mol_wt=260950
     Region          42..147
                     /region_name="CH_NAV2"
                     /note="calponin homology (CH) domain found in neuron
                     navigator 2; cd21285"
                     /db_xref="CDD:409134"
     Site            order(44,48,102,104..105,108..109,111,120..128,133,
                     135..136,138..139,142..143,146)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409134"
     Region          <243..672
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          900..>1201
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          <1621..>1893
                     /region_name="Mplasa_alph_rch"
                     /note="helix-rich Mycoplasma protein; TIGR04523"
                     /db_xref="CDD:275316"
     Region          1621..>1697
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          <1840..>1895
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          1925..2309
                     /region_name="McrB"
                     /note="5-methylcytosine-specific restriction endonuclease
                     McrBC, GTP-binding regulatory subunit McrB [Defense
                     mechanisms]; COG1401"
                     /db_xref="CDD:441011"
     CDS             1..2422
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /coded_by="XM_054370388.1:887..8155"
                     /db_xref="GeneID:89797"
                     /db_xref="HGNC:HGNC:15997"
                     /db_xref="MIM:607026"
ORIGIN      
        1 mpailvaskm ksglpkpvhs aapilhvppa ragpqpcylk lgskveiytd wanhylaksg
       61 hkrlikdlqq dvtdgvllaq iiqvvaneki edingcpknr sqmienidac lnflaakgin
      121 iqglsaeeir ngnlkailgl ffslsrykqq qqqpqkqhls splppavsqv agapsqcqag
      181 tpqqqvpvtp qapcqphqpa phqqskaqae mqsrlpgpta rvsaagseak trggsttann
      241 rrsqsfnnyd kskpvtsppp ppsshekepl assasshpgm sdnapasles gssstptncs
      301 tssaipqpga atkpwrsksl svkhsatvsm lsvkppgpea prptpeamkp apnnqksmle
      361 klklfnskgg skagegpgsr dtscerletl psfeeseele aasrmlttvg passspkial
      421 kgiaqrtfsr altnkksslk gnekekekqq rekdkekskd lakrasvter ldlkeepked
      481 psgaavpemp kksskiasfi pkggklnsak kepmapshsg ipkpgmksmp gkspsapaps
      541 kegersrsgk lssglpqqkp qldgrhssss sslassegkg pggttlnhsi ssqtvsgsvg
      601 ttqttgsntv svqlpqpqqq ynhpntatva pflyrsqtdt egnvtaesss tgvsvepshf
      661 tktgqpalee ltgedpearr lrtvkniadl rqnleetmss lrgtqvthst lettfdtnvt
      721 temsgrsils ltgrptplsw rlgqssprlq agdapsmgng yppranasrf intesgryvy
      781 saplrrqlas rgssvchvdv sdkagdemdl egismdapgy msdgdvlskn irtdditsgy
      841 mtdgglglyt rrlnrlpdgm avvretlqrn tslglgdads wddsssvssg isdtidnlst
      901 ddintsssis syantpassr knldvqtdae khsqvernsl wsgddvkksd ggsdsgikme
      961 pgskwrrnps dvsdesdkst sgkknpvisq tgswrrgmta qvgitmprtk asapagalkt
     1021 pgtgktddak vsekgrlspk asqvkrspsd agrssgdesk kplpsssrtp tanansfgfk
     1081 kqsgsaagla mitasgvtvt srsatlgkip kssalvsrsa grkssmdgaq nqddgylals
     1141 srtnlqyrsl prpsksnsrn gagnrsstss idsnissksa glpvpklrep sktalgsslp
     1201 glvnqtdkek gissdnesva scnsvkvnpa aqpvsspaqt slqpgakypd vasptlrrlf
     1261 ggkptkqvpi ataenmknsv visnphatmt qqgnldspsg sgvlssgsss plysknvdln
     1321 qsplasspss ahsapsnslt wgtnassssa vskdglgfqs vsslhtsces idislssggv
     1381 pshnsstgli asskddsltp fvrtnsvktt lsesplsspa aspkfcrstl prkqdsdphl
     1441 drntlpkkgl rytptsqlrt qedakewlrs hsagglqdta anspfssgss vtspsgtrfn
     1501 fsqlaspttv tqmslsnptm lrthslsnad gqydpytdsr frnssmslde ksrtmsrsgs
     1561 frdgfeeesw ekssvdnfvs rlhsslhfsl plfhharyel vhgsslslvs stssvystpe
     1621 ekcqseirkl rreldasqek vsalttqlta nahlvaafeq slgnmtirlq sltmtaeqkd
     1681 selnelrkti ellkkqnaaa qaaingvint pelnckgngt aqsadlrirr qhssdsvssi
     1741 nsatshssvg sniesdskkk krknwvnelr ssfkqafgkk kspksasshs dieemtdssl
     1801 psspklphng stgstpllrn shsnslisec mdseaetvmq lrnelrdkem kltdirleal
     1861 ssahqldqlr eamnrmqsei eklkaendrl ksesqgsgcs rapsqvsisa sprqsmglsq
     1921 hslnltests ldmllddtge csarkeggrh vkivvsfqee mkwkedsrph lfligcigvs
     1981 gktkwdvldg vvrrlfkeyi ihvdpvsqlg lnsdsvlgys igeikrsnts etpellpcgy
     2041 lvgenttisv tvkglaensl dslvfeslip kpilqryvsl liehrriils gpsgtgktyl
     2101 anrlseyivl regreltdgv iatfnvdhks skelrqylsn ladqcnsenn avdmplviil
     2161 dnlhhvsslg eifngllnck yhkcpyiigt mnqatsstpn lqlhhnfrwv lcanhtepvk
     2221 gflgrflrrk lmeteisgrv rnmelvkiid wipkvwhhln rfleahsssd vtigprlfls
     2281 cpidvdgsrv wftdlwnysi ipylleaire glqlygrrap wedpakwvmd typwaaspqq
     2341 hewppllqlr pedvgfdgys mpregstskq mppsdaegdp lmnmlmrlqe aanysspqsy
     2401 dsdsnsnshh ddildssles tl
//
LOCUS       XP_054226364            2418 aa            linear   PRI 05-AUG-2025
DEFINITION  neuron navigator 2 isoform X19 [Homo sapiens].
ACCESSION   XP_054226364
VERSION     XP_054226364.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370389.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2418
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2418
                     /product="neuron navigator 2 isoform X19"
                     /calculated_mol_wt=260030
     Region          77..190
                     /region_name="CH_NAV2"
                     /note="calponin homology (CH) domain found in neuron
                     navigator 2; cd21285"
                     /db_xref="CDD:409134"
     Site            order(87,91,145,147..148,151..152,154,163..171,176,
                     178..179,181..182,185..186,189)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409134"
     Region          <309..738
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          966..>1267
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          <1617..>1889
                     /region_name="Mplasa_alph_rch"
                     /note="helix-rich Mycoplasma protein; TIGR04523"
                     /db_xref="CDD:275316"
     Region          1617..>1693
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          1828..>1886
                     /region_name="Atg16_CCD"
                     /note="Coiled-coiled domain of autophagy-related 16
                     (Atg16) family proteins; cl46300"
                     /db_xref="CDD:480640"
     Region          1921..2305
                     /region_name="McrB"
                     /note="5-methylcytosine-specific restriction endonuclease
                     McrBC, GTP-binding regulatory subunit McrB [Defense
                     mechanisms]; COG1401"
                     /db_xref="CDD:441011"
     CDS             1..2418
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /coded_by="XM_054370389.1:860..8116"
                     /db_xref="GeneID:89797"
                     /db_xref="HGNC:HGNC:15997"
                     /db_xref="MIM:607026"
ORIGIN      
        1 mpailvaskm ksglpkpvhs aapilhvppa ragpqpcylk lgskvevskt typsqiplks
       61 qvlqglqepa geglplrksg svengfdtqi ytdwanhyla ksghkrlikd lqqdvtdgvl
      121 laqiiqvvan ekiedingcp knrsqmieni daclnflaak giniqglsae eirngnlkai
      181 lglffslsry kqqqqqpqkq hlssplppav sqvagapsqc qagtpqqqvp vtpqapcqph
      241 qpaphqqska qaemqssass kdssqskiir ftlgqkkisr lpgptarvsa agseaktrgg
      301 sttannrrsq sfnnydkskp vtspppppss hekeplassa sshpgmsdna paslesgsss
      361 tptncstssa ipqpgaatkp wrskslsvkh satvsmlsvk ppgpeaprpt peamkpapnn
      421 qksmleklkl fnskggskag egpgsrdtsc erletlpsfe eseeleaasr mlttvgpass
      481 spkialkgia qrtfsraltn kksslkgnek ekekqqrekd kekskdlakr asvterldlk
      541 eepkedpsga avpempkkss kiasfipkgg klnsakkepm apshsgipkp gmksmpgksp
      601 sapapskege rsrsgklssg lpqqkpqldg rhssssssla ssegkgpggt tlnhsissqt
      661 vsgsvgttqt tgsntvsvql pqpqqqynhp ntatvapfly rsqtdtegnv taessstgvs
      721 vepshftktg qpaleeltge dpearrlrtv kniadlrqnl eetmsslrgt qvthstlett
      781 fdtnvttems grsilsltgr ptplswrlgq ssprlqagda psmgngyppr anasrfinte
      841 sgryvysapl rrqlasrgss vchvdvsdka gdemdlegis mdapgymsdg dvlsknirtd
      901 ditsgymtdg glglytrrln rlpdgmavvr etlqrntslg lgdadswdds ssvssgisdt
      961 idnlstddin tsssissyan tpassrknld vqtdaekhsq vernslwsgd dvkksdggsd
     1021 sgikmepgsk wrrnpsdvsd esdkstsgkk npvisqtgsw rrgmtaqvgi tmprtkasap
     1081 agalktpgtg ktddakvsek grlspkasqv krspsdagrs sgdeskkplp sssrtptana
     1141 nsfgfkkqsg saaglamita sgvtvtsrsa tlgkipkssa lvsrsagrks smdgaqnqdd
     1201 gylalssrtn lqyrslprps ksnsrngagn rsstssidsn issksaglpv pklrepskta
     1261 lgsslpglvn qtdkekgiss dnesvascns vkvnpaaqpv sspaqtslqp gakypdvasp
     1321 tlrrlfggkp tkqvpiatae nmknsvvisn phatmtqqgn ldspsgsgvl ssgsssplys
     1381 knvdlnqspl asspssahsa psnsltwgtn assssavskd glgfqsvssl htscesidis
     1441 lssggvpshn sstgliassk ddsltpfvrt nsvkttlser ytptsqlrtq edakewlrsh
     1501 sagglqdtaa nspfssgssv tspsgtrfnf sqlaspttvt qmslsnptml rthslsnadg
     1561 qydpytdsrf rnssmsldek srtmsrsgsf rdgfeevhgs slslvsstss vystpeekcq
     1621 seirklrrel dasqekvsal ttqltanahl vaafeqslgn mtirlqsltm taeqkdseln
     1681 elrktiellk kqnaaaqaai ngvintpeln ckgngtaqsa dlrirrqhss dsvssinsat
     1741 shssvgsnie sdskkkkrkn wvnelrssfk qafgkkkspk sasshsdiee mtdsslpssp
     1801 klphngstgs tpllrnshsn slisecmdse aetvmqlrne lrdkemkltd irlealssah
     1861 qldqlreamn rmqseieklk aendrlkses qgsgcsraps qvsisasprq smglsqhsln
     1921 ltestsldml lddtgecsar keggrhvkiv vsfqeemkwk edsrphlfli gcigvsgktk
     1981 wdvldgvvrr lfkeyiihvd pvsqlglnsd svlgysigei krsntsetpe llpcgylvge
     2041 nttisvtvkg laensldslv feslipkpil qryvsllieh rriilsgpsg tgktylanrl
     2101 seyivlregr eltdgviatf nvdhksskel rqylsnladq cnsennavdm plviildnlh
     2161 hvsslgeifn gllnckyhkc pyiigtmnqa tsstpnlqlh hnfrwvlcan htepvkgflg
     2221 rflrrklmet eisgrvrnme lvkiidwipk vwhhlnrfle ahsssdvtig prlflscpid
     2281 vdgsrvwftd lwnysiipyl leaireglql ygrrapwedp akwvmdtypw aaspqqhewp
     2341 pllqlrpedv gfdgysmpre gstskqmpps daegdplmnm lmrlqeaany sspqsydsds
     2401 nsnshhddil dsslestl
//
LOCUS       XP_054226365            2416 aa            linear   PRI 05-AUG-2025
DEFINITION  neuron navigator 2 isoform X20 [Homo sapiens].
ACCESSION   XP_054226365
VERSION     XP_054226365.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370390.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2416
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2416
                     /product="neuron navigator 2 isoform X20"
                     /calculated_mol_wt=260811
     Region          5..118
                     /region_name="CH_NAV2"
                     /note="calponin homology (CH) domain found in neuron
                     navigator 2; cd21285"
                     /db_xref="CDD:409134"
     Site            order(15,19,73,75..76,79..80,82,91..99,104,106..107,
                     109..110,113..114,117)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409134"
     Region          <237..666
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          894..>1195
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          <1615..>1887
                     /region_name="Mplasa_alph_rch"
                     /note="helix-rich Mycoplasma protein; TIGR04523"
                     /db_xref="CDD:275316"
     Region          1615..>1691
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          <1834..>1889
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          1919..2303
                     /region_name="McrB"
                     /note="5-methylcytosine-specific restriction endonuclease
                     McrBC, GTP-binding regulatory subunit McrB [Defense
                     mechanisms]; COG1401"
                     /db_xref="CDD:441011"
     CDS             1..2416
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /coded_by="XM_054370390.1:358..7608"
                     /db_xref="GeneID:89797"
                     /db_xref="HGNC:HGNC:15997"
                     /db_xref="MIM:607026"
ORIGIN      
        1 msvmlwrweq nnttmkliyt dwanhylaks ghkrlikdlq qdvtdgvlla qiiqvvanek
       61 iedingcpkn rsqmienida clnflaakgi niqglsaeei rngnlkailg lffslsrykq
      121 qqqqpqkqhl ssplppavsq vagapsqcqa gtpqqqvpvt pqapcqphqp aphqqskaqa
      181 emqssasskd ssqskiirft lgqkkisrlp gptarvsaag seaktrggst tannrrsqsf
      241 nnydkskpvt spppppsshe keplassass hpgmsdnapa slesgssstp tncstssaip
      301 qpgaatkpwr skslsvkhsa tvsmlsvkpp gpeaprptpe amkpapnnqk smleklklfn
      361 skggskageg pgsrdtscer letlpsfees eeleaasrml ttvgpasssp kialkgiaqr
      421 tfsraltnkk sslkgnekek ekqqrekdke kskdlakras vterldlkee pkedpsgaav
      481 pempkksski asfipkggkl nsakkepmap shsgipkpgm ksmpgkspsa papskegers
      541 rsgklssglp qqkpqldgrh sssssslass egkgpggttl nhsissqtvs gsvgttqttg
      601 sntvsvqlpq pqqqynhpnt atvapflyrs qtdtegnvta essstgvsve pshftktgqp
      661 aleeltgedp earrlrtvkn iadlrqnlee tmsslrgtqv thstlettfd tnvttemsgr
      721 silsltgrpt plswrlgqss prlqagdaps mgngyppran asrfintesg ryvysaplrr
      781 qlasrgssvc hvdvsdkagd emdlegismd apgymsdgdv lsknirtddi tsgymtdggl
      841 glytrrlnrl pdgmavvret lqrntslglg dadswddsss vssgisdtid nlstddints
      901 ssissyantp assrknldvq tdaekhsqve rnslwsgddv kksdggsdsg ikmepgskwr
      961 rnpsdvsdes dkstsgkknp visqtgswrr gmtaqvgitm prtkasapag alktpgtgkt
     1021 ddakvsekgr lspkasqvkr spsdagrssg deskkplpss srtptanans fgfkkqsgsa
     1081 aglamitasg vtvtsrsatl gkipkssalv srsagrkssm dgaqnqddgy lalssrtnlq
     1141 yrslprpsks nsrngagnrs stssidsnis sksaglpvpk lrepsktalg sslpglvnqt
     1201 dkekgissdn esvascnsvk vnpaaqpvss paqtslqpga kypdvasptl rrlfggkptk
     1261 qvpiataenm knsvvisnph atmtqqgnld spsgsgvlss gsssplyskn vdlnqsplas
     1321 spssahsaps nsltwgtnas sssavskdgl gfqsvsslht scesidisls sggvpshnss
     1381 tgliasskdd sltpfvrtns vkttlsespl sspaaspkfc rstlprkqds dphldrntlp
     1441 kkglrytpts qlrtqedake wlrshsaggl qdtaanspfs sgssvtspsg trfnfsqlas
     1501 pttvtqmsls nptmlrthsl snadgqydpy tdsrfrnssm sldeksrtms rsgsfrdgfe
     1561 eeswekssvd nfvsrlhssl hfslplfhha ryelvhgssl slvsstssvy stpeekcqse
     1621 irklrrelda sqekvsaltt qltanahlva afeqslgnmt irlqsltmta eqkdselnel
     1681 rktiellkkq naaaqaaing vintpelnck gngtaqsadl rirrqhssds vssinsatsh
     1741 ssvgsniesd skkkkrknwv nelrssfkqa fgkkkspksa sshsdieemt dsslpsspkl
     1801 phngstgstp llrnshsnsl isecmdseae tvmqlrnelr dkemkltdir lealssahql
     1861 dqlreamnrm qseieklkae ndrlksesqg sgcsrapsqv sisasprqsm glsqhslnlt
     1921 estsldmlld dtgecsarke ggrhvkivvs fqeemkwked srphlfligc igvsgktkwd
     1981 vldgvvrrlf keyiihvdpv sqlglnsdsv lgysigeikr sntsetpell pcgylvgent
     2041 tisvtvkgla ensldslvfe slipkpilqr yvslliehrr iilsgpsgtg ktylanrlse
     2101 yivlregrel tdgviatfnv dhksskelrq ylsnladqcn sennavdmpl viildnlhhv
     2161 sslgeifngl lnckyhkcpy iigtmnqats stpnlqlhhn frwvlcanht epvkgflgrf
     2221 lrrklmetei sgrvrnmelv kiidwipkvw hhlnrfleah sssdvtigpr lflscpidvd
     2281 gsrvwftdlw nysiipylle aireglqlyg rrapwedpak wvmdtypwaa spqqhewppl
     2341 lqlrpedvgf dgysmpregs tskqmppsda egdplmnmlm rlqeaanyss pqsydsdsns
     2401 nshhddilds slestl
//
LOCUS       XP_054226366            2415 aa            linear   PRI 05-AUG-2025
DEFINITION  neuron navigator 2 isoform X21 [Homo sapiens].
ACCESSION   XP_054226366
VERSION     XP_054226366.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370391.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2415
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2415
                     /product="neuron navigator 2 isoform X21"
                     /calculated_mol_wt=259688
     Region          77..190
                     /region_name="CH_NAV2"
                     /note="calponin homology (CH) domain found in neuron
                     navigator 2; cd21285"
                     /db_xref="CDD:409134"
     Site            order(87,91,145,147..148,151..152,154,163..171,176,
                     178..179,181..182,185..186,189)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409134"
     Region          <309..738
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          966..>1267
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          1617..>1693
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          1825..>1883
                     /region_name="Atg16_CCD"
                     /note="Coiled-coiled domain of autophagy-related 16
                     (Atg16) family proteins; cl46300"
                     /db_xref="CDD:480640"
     Region          1918..2302
                     /region_name="McrB"
                     /note="5-methylcytosine-specific restriction endonuclease
                     McrBC, GTP-binding regulatory subunit McrB [Defense
                     mechanisms]; COG1401"
                     /db_xref="CDD:441011"
     CDS             1..2415
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /coded_by="XM_054370391.1:860..8107"
                     /db_xref="GeneID:89797"
                     /db_xref="HGNC:HGNC:15997"
                     /db_xref="MIM:607026"
ORIGIN      
        1 mpailvaskm ksglpkpvhs aapilhvppa ragpqpcylk lgskvevskt typsqiplks
       61 qvlqglqepa geglplrksg svengfdtqi ytdwanhyla ksghkrlikd lqqdvtdgvl
      121 laqiiqvvan ekiedingcp knrsqmieni daclnflaak giniqglsae eirngnlkai
      181 lglffslsry kqqqqqpqkq hlssplppav sqvagapsqc qagtpqqqvp vtpqapcqph
      241 qpaphqqska qaemqssass kdssqskiir ftlgqkkisr lpgptarvsa agseaktrgg
      301 sttannrrsq sfnnydkskp vtspppppss hekeplassa sshpgmsdna paslesgsss
      361 tptncstssa ipqpgaatkp wrskslsvkh satvsmlsvk ppgpeaprpt peamkpapnn
      421 qksmleklkl fnskggskag egpgsrdtsc erletlpsfe eseeleaasr mlttvgpass
      481 spkialkgia qrtfsraltn kksslkgnek ekekqqrekd kekskdlakr asvterldlk
      541 eepkedpsga avpempkkss kiasfipkgg klnsakkepm apshsgipkp gmksmpgksp
      601 sapapskege rsrsgklssg lpqqkpqldg rhssssssla ssegkgpggt tlnhsissqt
      661 vsgsvgttqt tgsntvsvql pqpqqqynhp ntatvapfly rsqtdtegnv taessstgvs
      721 vepshftktg qpaleeltge dpearrlrtv kniadlrqnl eetmsslrgt qvthstlett
      781 fdtnvttems grsilsltgr ptplswrlgq ssprlqagda psmgngyppr anasrfinte
      841 sgryvysapl rrqlasrgss vchvdvsdka gdemdlegis mdapgymsdg dvlsknirtd
      901 ditsgymtdg glglytrrln rlpdgmavvr etlqrntslg lgdadswdds ssvssgisdt
      961 idnlstddin tsssissyan tpassrknld vqtdaekhsq vernslwsgd dvkksdggsd
     1021 sgikmepgsk wrrnpsdvsd esdkstsgkk npvisqtgsw rrgmtaqvgi tmprtkasap
     1081 agalktpgtg ktddakvsek grlspkasqv krspsdagrs sgdeskkplp sssrtptana
     1141 nsfgfkkqsg saaglamita sgvtvtsrsa tlgkipkssa lvsrsagrks smdgaqnqdd
     1201 gylalssrtn lqyrslprps ksnsrngagn rsstssidsn issksaglpv pklrepskta
     1261 lgsslpglvn qtdkekgiss dnesvascns vkvnpaaqpv sspaqtslqp gakypdvasp
     1321 tlrrlfggkp tkqvpiatae nmknsvvisn phatmtqqgn ldspsgsgvl ssgsssplys
     1381 knvdlnqspl asspssahsa psnsltwgtn assssavskd glgfqsvssl htscesidis
     1441 lssggvpshn sstgliassk ddsltpfvrt nsvkttlser ytptsqlrtq edakewlrsh
     1501 sagglqdtaa nspfssgssv tspsgtrfnf sqlaspttvt qmslsnptml rthslsnadg
     1561 qydpytdsrf rnssmsldek srtmsrsgsf rdgfeevhgs slslvsstss vystpeekcq
     1621 seirklrrel dasqekvsal ttqltanahl vaafeqslgn mtirlqsltm taeqkdseln
     1681 elrktiellk kqnaaaqaai ngvintpeln ckgngtaqsa dlrirrqhss dsvssinsat
     1741 shssvgsnie sdskkkkrkn wlrssfkqaf gkkkspksas shsdieemtd sslpsspklp
     1801 hngstgstpl lrnshsnsli secmdseaet vmqlrnelrd kemkltdirl ealssahqld
     1861 qlreamnrmq seieklkaen drlksesqgs gcsrapsqvs isasprqsmg lsqhslnlte
     1921 stsldmlldd tgecsarkeg grhvkivvsf qeemkwkeds rphlfligci gvsgktkwdv
     1981 ldgvvrrlfk eyiihvdpvs qlglnsdsvl gysigeikrs ntsetpellp cgylvgentt
     2041 isvtvkglae nsldslvfes lipkpilqry vslliehrri ilsgpsgtgk tylanrlsey
     2101 ivlregrelt dgviatfnvd hksskelrqy lsnladqcns ennavdmplv iildnlhhvs
     2161 slgeifngll nckyhkcpyi igtmnqatss tpnlqlhhnf rwvlcanhte pvkgflgrfl
     2221 rrklmeteis grvrnmelvk iidwipkvwh hlnrfleahs ssdvtigprl flscpidvdg
     2281 srvwftdlwn ysiipyllea ireglqlygr rapwedpakw vmdtypwaas pqqhewppll
     2341 qlrpedvgfd gysmpregst skqmppsdae gdplmnmlmr lqeaanyssp qsydsdsnsn
     2401 shhddildss lestl
//
LOCUS       XP_054226367            2410 aa            linear   PRI 05-AUG-2025
DEFINITION  neuron navigator 2 isoform X22 [Homo sapiens].
ACCESSION   XP_054226367
VERSION     XP_054226367.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370392.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2410
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2410
                     /product="neuron navigator 2 isoform X22"
                     /calculated_mol_wt=259225
     Region          77..190
                     /region_name="CH_NAV2"
                     /note="calponin homology (CH) domain found in neuron
                     navigator 2; cd21285"
                     /db_xref="CDD:409134"
     Site            order(87,91,145,147..148,151..152,154,163..171,176,
                     178..179,181..182,185..186,189)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409134"
     Region          <286..715
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          943..>1244
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          <1609..>1881
                     /region_name="Mplasa_alph_rch"
                     /note="helix-rich Mycoplasma protein; TIGR04523"
                     /db_xref="CDD:275316"
     Region          1609..>1685
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          1820..>1878
                     /region_name="Atg16_CCD"
                     /note="Coiled-coiled domain of autophagy-related 16
                     (Atg16) family proteins; cl46300"
                     /db_xref="CDD:480640"
     Region          1913..2297
                     /region_name="McrB"
                     /note="5-methylcytosine-specific restriction endonuclease
                     McrBC, GTP-binding regulatory subunit McrB [Defense
                     mechanisms]; COG1401"
                     /db_xref="CDD:441011"
     CDS             1..2410
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /coded_by="XM_054370392.1:860..8092"
                     /db_xref="GeneID:89797"
                     /db_xref="HGNC:HGNC:15997"
                     /db_xref="MIM:607026"
ORIGIN      
        1 mpailvaskm ksglpkpvhs aapilhvppa ragpqpcylk lgskvevskt typsqiplks
       61 qvlqglqepa geglplrksg svengfdtqi ytdwanhyla ksghkrlikd lqqdvtdgvl
      121 laqiiqvvan ekiedingcp knrsqmieni daclnflaak giniqglsae eirngnlkai
      181 lglffslsry kqqqqqpqkq hlssplppav sqvagapsqc qagtpqqqvp vtpqapcqph
      241 qpaphqqska qaemqsrlpg ptarvsaags eaktrggstt annrrsqsfn nydkskpvts
      301 pppppsshek eplassassh pgmsdnapas lesgssstpt ncstssaipq pgaatkpwrs
      361 kslsvkhsat vsmlsvkppg peaprptpea mkpapnnqks mleklklfns kggskagegp
      421 gsrdtscerl etlpsfeese eleaasrmlt tvgpassspk ialkgiaqrt fsraltnkks
      481 slkgnekeke kqqrekdkek skdlakrasv terldlkeep kedpsgaavp empkksskia
      541 sfipkggkln sakkepmaps hsgipkpgmk smpgkspsap apskegersr sgklssglpq
      601 qkpqldgrhs ssssslasse gkgpggttln hsissqtvsg svgttqttgs ntvsvqlpqp
      661 qqqynhpnta tvapflyrsq tdtegnvtae ssstgvsvep shftktgqpa leeltgedpe
      721 arrlrtvkni adlrqnleet msslrgtqvt hstlettfdt nvttemsgrs ilsltgrptp
      781 lswrlgqssp rlqagdapsm gngypprana srfintesgr yvysaplrrq lasrgssvch
      841 vdvsdkagde mdlegismda pgymsdgdvl sknirtddit sgymtdgglg lytrrlnrlp
      901 dgmavvretl qrntslglgd adswddsssv ssgisdtidn lstddintss sissyantpa
      961 ssrknldvqt daekhsqver nslwsgddvk ksdggsdsgi kmepgskwrr npsdvsdesd
     1021 kstsgkknpv isqtgswrrg mtaqvgitmp rtkasapaga lktpgtgktd dakvsekgrl
     1081 spkasqvkrs psdagrssgd eskkplpsss rtptanansf gfkkqsgsaa glamitasgv
     1141 tvtsrsatlg kipkssalvs rsagrkssmd gaqnqddgyl alssrtnlqy rslprpsksn
     1201 srngagnrss tssidsniss ksaglpvpkl repsktalgs slpglvnqtd kekgissdne
     1261 svascnsvkv npaaqpvssp aqtslqpgak ypdvasptlr rlfggkptkq vpiataenmk
     1321 nsvvisnpha tmtqqgnlds psgsgvlssg sssplysknv dlnqsplass pssahsapsn
     1381 sltwgtnass ssavskdglg fqsvsslhts cesidislss ggvpshnsst gliasskdds
     1441 ltpfvrtnsv kttlsesdph ldrntlpkkg lrytptsqlr tqedakewlr shsagglqdt
     1501 aanspfssgs svtspsgtrf nfsqlasptt vtqmslsnpt mlrthslsna dgqydpytds
     1561 rfrnssmsld eksrtmsrsg sfrdgfeevh gsslslvsst ssvystpeek cqseirklrr
     1621 eldasqekvs alttqltana hlvaafeqsl gnmtirlqsl tmtaeqkdse lnelrktiel
     1681 lkkqnaaaqa aingvintpe lnckgngtaq sadlrirrqh ssdsvssins atshssvgsn
     1741 iesdskkkkr knwvnelrss fkqafgkkks pksasshsdi eemtdsslps spklphngst
     1801 gstpllrnsh snslisecmd seaetvmqlr nelrdkemkl tdirlealss ahqldqlrea
     1861 mnrmqseiek lkaendrlks esqgsgcsra psqvsisasp rqsmglsqhs lnltestsld
     1921 mllddtgecs arkeggrhvk ivvsfqeemk wkedsrphlf ligcigvsgk tkwdvldgvv
     1981 rrlfkeyiih vdpvsqlgln sdsvlgysig eikrsntset pellpcgylv genttisvtv
     2041 kglaenslds lvfeslipkp ilqryvslli ehrriilsgp sgtgktylan rlseyivlre
     2101 greltdgvia tfnvdhkssk elrqylsnla dqcnsennav dmplviildn lhhvsslgei
     2161 fngllnckyh kcpyiigtmn qatsstpnlq lhhnfrwvlc anhtepvkgf lgrflrrklm
     2221 eteisgrvrn melvkiidwi pkvwhhlnrf leahsssdvt igprlflscp idvdgsrvwf
     2281 tdlwnysiip ylleairegl qlygrrapwe dpakwvmdty pwaaspqqhe wppllqlrpe
     2341 dvgfdgysmp regstskqmp psdaegdplm nmlmrlqeaa nysspqsyds dsnsnshhdd
     2401 ildsslestl
//
LOCUS       XP_054226368            2407 aa            linear   PRI 05-AUG-2025
DEFINITION  neuron navigator 2 isoform X23 [Homo sapiens].
ACCESSION   XP_054226368
VERSION     XP_054226368.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370393.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2407
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2407
                     /product="neuron navigator 2 isoform X23"
                     /calculated_mol_wt=258882
     Region          77..190
                     /region_name="CH_NAV2"
                     /note="calponin homology (CH) domain found in neuron
                     navigator 2; cd21285"
                     /db_xref="CDD:409134"
     Site            order(87,91,145,147..148,151..152,154,163..171,176,
                     178..179,181..182,185..186,189)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409134"
     Region          <286..715
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          943..>1244
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          1609..>1685
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          1817..>1875
                     /region_name="Atg16_CCD"
                     /note="Coiled-coiled domain of autophagy-related 16
                     (Atg16) family proteins; cl46300"
                     /db_xref="CDD:480640"
     Region          1910..2294
                     /region_name="McrB"
                     /note="5-methylcytosine-specific restriction endonuclease
                     McrBC, GTP-binding regulatory subunit McrB [Defense
                     mechanisms]; COG1401"
                     /db_xref="CDD:441011"
     CDS             1..2407
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /coded_by="XM_054370393.1:860..8083"
                     /db_xref="GeneID:89797"
                     /db_xref="HGNC:HGNC:15997"
                     /db_xref="MIM:607026"
ORIGIN      
        1 mpailvaskm ksglpkpvhs aapilhvppa ragpqpcylk lgskvevskt typsqiplks
       61 qvlqglqepa geglplrksg svengfdtqi ytdwanhyla ksghkrlikd lqqdvtdgvl
      121 laqiiqvvan ekiedingcp knrsqmieni daclnflaak giniqglsae eirngnlkai
      181 lglffslsry kqqqqqpqkq hlssplppav sqvagapsqc qagtpqqqvp vtpqapcqph
      241 qpaphqqska qaemqsrlpg ptarvsaags eaktrggstt annrrsqsfn nydkskpvts
      301 pppppsshek eplassassh pgmsdnapas lesgssstpt ncstssaipq pgaatkpwrs
      361 kslsvkhsat vsmlsvkppg peaprptpea mkpapnnqks mleklklfns kggskagegp
      421 gsrdtscerl etlpsfeese eleaasrmlt tvgpassspk ialkgiaqrt fsraltnkks
      481 slkgnekeke kqqrekdkek skdlakrasv terldlkeep kedpsgaavp empkksskia
      541 sfipkggkln sakkepmaps hsgipkpgmk smpgkspsap apskegersr sgklssglpq
      601 qkpqldgrhs ssssslasse gkgpggttln hsissqtvsg svgttqttgs ntvsvqlpqp
      661 qqqynhpnta tvapflyrsq tdtegnvtae ssstgvsvep shftktgqpa leeltgedpe
      721 arrlrtvkni adlrqnleet msslrgtqvt hstlettfdt nvttemsgrs ilsltgrptp
      781 lswrlgqssp rlqagdapsm gngypprana srfintesgr yvysaplrrq lasrgssvch
      841 vdvsdkagde mdlegismda pgymsdgdvl sknirtddit sgymtdgglg lytrrlnrlp
      901 dgmavvretl qrntslglgd adswddsssv ssgisdtidn lstddintss sissyantpa
      961 ssrknldvqt daekhsqver nslwsgddvk ksdggsdsgi kmepgskwrr npsdvsdesd
     1021 kstsgkknpv isqtgswrrg mtaqvgitmp rtkasapaga lktpgtgktd dakvsekgrl
     1081 spkasqvkrs psdagrssgd eskkplpsss rtptanansf gfkkqsgsaa glamitasgv
     1141 tvtsrsatlg kipkssalvs rsagrkssmd gaqnqddgyl alssrtnlqy rslprpsksn
     1201 srngagnrss tssidsniss ksaglpvpkl repsktalgs slpglvnqtd kekgissdne
     1261 svascnsvkv npaaqpvssp aqtslqpgak ypdvasptlr rlfggkptkq vpiataenmk
     1321 nsvvisnpha tmtqqgnlds psgsgvlssg sssplysknv dlnqsplass pssahsapsn
     1381 sltwgtnass ssavskdglg fqsvsslhts cesidislss ggvpshnsst gliasskdds
     1441 ltpfvrtnsv kttlsesdph ldrntlpkkg lrytptsqlr tqedakewlr shsagglqdt
     1501 aanspfssgs svtspsgtrf nfsqlasptt vtqmslsnpt mlrthslsna dgqydpytds
     1561 rfrnssmsld eksrtmsrsg sfrdgfeevh gsslslvsst ssvystpeek cqseirklrr
     1621 eldasqekvs alttqltana hlvaafeqsl gnmtirlqsl tmtaeqkdse lnelrktiel
     1681 lkkqnaaaqa aingvintpe lnckgngtaq sadlrirrqh ssdsvssins atshssvgsn
     1741 iesdskkkkr knwlrssfkq afgkkkspks asshsdieem tdsslpsspk lphngstgst
     1801 pllrnshsns lisecmdsea etvmqlrnel rdkemkltdi rlealssahq ldqlreamnr
     1861 mqseieklka endrlksesq gsgcsrapsq vsisasprqs mglsqhslnl testsldmll
     1921 ddtgecsark eggrhvkivv sfqeemkwke dsrphlflig cigvsgktkw dvldgvvrrl
     1981 fkeyiihvdp vsqlglnsds vlgysigeik rsntsetpel lpcgylvgen ttisvtvkgl
     2041 aensldslvf eslipkpilq ryvslliehr riilsgpsgt gktylanrls eyivlregre
     2101 ltdgviatfn vdhksskelr qylsnladqc nsennavdmp lviildnlhh vsslgeifng
     2161 llnckyhkcp yiigtmnqat sstpnlqlhh nfrwvlcanh tepvkgflgr flrrklmete
     2221 isgrvrnmel vkiidwipkv whhlnrflea hsssdvtigp rlflscpidv dgsrvwftdl
     2281 wnysiipyll eaireglqly grrapwedpa kwvmdtypwa aspqqhewpp llqlrpedvg
     2341 fdgysmpreg stskqmppsd aegdplmnml mrlqeaanys spqsydsdsn snshhddild
     2401 sslestl
//
LOCUS       XP_054226369            2401 aa            linear   PRI 05-AUG-2025
DEFINITION  neuron navigator 2 isoform X24 [Homo sapiens].
ACCESSION   XP_054226369
VERSION     XP_054226369.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370394.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2401
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2401
                     /product="neuron navigator 2 isoform X24"
                     /calculated_mol_wt=259089
     Region          15..126
                     /region_name="CH_NAV2"
                     /note="calponin homology (CH) domain found in neuron
                     navigator 2; cd21285"
                     /db_xref="CDD:409134"
     Site            order(23,27,81,83..84,87..88,90,99..107,112,114..115,
                     117..118,121..122,125)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409134"
     Region          <143..>330
                     /region_name="PRK07003"
                     /note="DNA polymerase III subunit gamma/tau"
                     /db_xref="CDD:235906"
     Region          <222..651
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          879..>1180
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          <1600..>1872
                     /region_name="Mplasa_alph_rch"
                     /note="helix-rich Mycoplasma protein; TIGR04523"
                     /db_xref="CDD:275316"
     Region          1600..>1676
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          1811..>1869
                     /region_name="Atg16_CCD"
                     /note="Coiled-coiled domain of autophagy-related 16
                     (Atg16) family proteins; cl46300"
                     /db_xref="CDD:480640"
     Region          1904..2288
                     /region_name="McrB"
                     /note="5-methylcytosine-specific restriction endonuclease
                     McrBC, GTP-binding regulatory subunit McrB [Defense
                     mechanisms]; COG1401"
                     /db_xref="CDD:441011"
     CDS             1..2401
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /coded_by="XM_054370394.1:771..7976"
                     /db_xref="GeneID:89797"
                     /db_xref="HGNC:HGNC:15997"
                     /db_xref="MIM:607026"
ORIGIN      
        1 mesvsessqq qkrkpvihgl edqkriytdw anhylaksgh krlikdlqqd vtdgvllaqi
       61 iqvvanekie dingcpknrs qmienidacl nflaakgini qglsaeeirn gnlkailglf
      121 fslsrykqqq qqpqkqhlss plppavsqva gapsqcqagt pqqqvpvtpq apcqphqpap
      181 hqqskaqaem qsrlpgptar vsaagseakt rggsttannr rsqsfnnydk skpvtspppp
      241 psshekepla ssasshpgms dnapaslesg ssstptncst ssaipqpgaa tkpwrsksls
      301 vkhsatvsml svkppgpeap rptpeamkpa pnnqksmlek lklfnskggs kagegpgsrd
      361 tscerletlp sfeeseelea asrmlttvgp assspkialk giaqrtfsra ltnkksslkg
      421 nekekekqqr ekdkekskdl akrasvterl dlkeepkedp sgaavpempk ksskiasfip
      481 kggklnsakk epmapshsgi pkpgmksmpg kspsapapsk egersrsgkl ssglpqqkpq
      541 ldgrhsssss slassegkgp ggttlnhsis sqtvsgsvgt tqttgsntvs vqlpqpqqqy
      601 nhpntatvap flyrsqtdte gnvtaessst gvsvepshft ktgqpaleel tgedpearrl
      661 rtvkniadlr qnleetmssl rgtqvthstl ettfdtnvtt emsgrsilsl tgrptplswr
      721 lgqssprlqa gdapsmgngy ppranasrfi ntesgryvys aplrrqlasr gssvchvdvs
      781 dkagdemdle gismdapgym sdgdvlskni rtdditsgym tdgglglytr rlnrlpdgma
      841 vvretlqrnt slglgdadsw ddsssvssgi sdtidnlstd dintsssiss yantpassrk
      901 nldvqtdaek hsqvernslw sgddvkksdg gsdsgikmep gskwrrnpsd vsdesdksts
      961 gkknpvisqt gswrrgmtaq vgitmprtka sapagalktp gtgktddakv sekgrlspka
     1021 sqvkrspsda grssgdeskk plpsssrtpt anansfgfkk qsgsaaglam itasgvtvts
     1081 rsatlgkipk ssalvsrsag rkssmdgaqn qddgylalss rtnlqyrslp rpsksnsrng
     1141 agnrsstssi dsnissksag lpvpklreps ktalgsslpg lvnqtdkekg issdnesvas
     1201 cnsvkvnpaa qpvsspaqts lqpgakypdv asptlrrlfg gkptkqvpia taenmknsvv
     1261 isnphatmtq qgnldspsgs gvlssgsssp lysknvdlnq splasspssa hsapsnsltw
     1321 gtnassssav skdglgfqsv sslhtscesi dislssggvp shnsstglia sskddsltpf
     1381 vrtnsvkttl sesplsspaa spkfcrstlp rkqdsdphld rntlpkkglr ytptsqlrtq
     1441 edakewlrsh sagglqdtaa nspfssgssv tspsgtrfnf sqlaspttvt qmslsnptml
     1501 rthslsnadg qydpytdsrf rnssmsldek srtmsrsgsf rdgfeeeswe kssvdnfvsr
     1561 lhsslhfslp lfhharyelv hgsslslvss tssvystpee kcqseirklr reldasqekv
     1621 salttqltan ahlvaafeqs lgnmtirlqs ltmtaeqkds elnelrktie llkkqnaaaq
     1681 aaingvintp elnckgngta qsadlrirrq hssdsvssin satshssvgs niesdskkkk
     1741 rknwvnelrs sfkqafgkkk spksasshsd ieemtdsslp sspklphngs tgstpllrns
     1801 hsnslisecm dseaetvmql rnelrdkemk ltdirleals sahqldqlre amnrmqseie
     1861 klkaendrlk sesqgsgcsr apsqvsisas prqsmglsqh slnltestsl dmllddtgec
     1921 sarkeggrhv kivvsfqeem kwkedsrphl fligcigvsg ktkwdvldgv vrrlfkeyii
     1981 hvdpvsqlgl nsdsvlgysi geikrsntse tpellpcgyl vgenttisvt vkglaensld
     2041 slvfeslipk pilqryvsll iehrriilsg psgtgktyla nrlseyivlr egreltdgvi
     2101 atfnvdhkss kelrqylsnl adqcnsenna vdmplviild nlhhvsslge ifngllncky
     2161 hkcpyiigtm nqatsstpnl qlhhnfrwvl canhtepvkg flgrflrrkl meteisgrvr
     2221 nmelvkiidw ipkvwhhlnr fleahsssdv tigprlflsc pidvdgsrvw ftdlwnysii
     2281 pylleaireg lqlygrrapw edpakwvmdt ypwaaspqqh ewppllqlrp edvgfdgysm
     2341 pregstskqm ppsdaegdpl mnmlmrlqea anysspqsyd sdsnsnshhd dildsslest
     2401 l
//
LOCUS       XP_054226370            2401 aa            linear   PRI 05-AUG-2025
DEFINITION  neuron navigator 2 isoform X24 [Homo sapiens].
ACCESSION   XP_054226370
VERSION     XP_054226370.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370395.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2401
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2401
                     /product="neuron navigator 2 isoform X24"
                     /calculated_mol_wt=259089
     Region          15..126
                     /region_name="CH_NAV2"
                     /note="calponin homology (CH) domain found in neuron
                     navigator 2; cd21285"
                     /db_xref="CDD:409134"
     Site            order(23,27,81,83..84,87..88,90,99..107,112,114..115,
                     117..118,121..122,125)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409134"
     Region          <143..>330
                     /region_name="PRK07003"
                     /note="DNA polymerase III subunit gamma/tau"
                     /db_xref="CDD:235906"
     Region          <222..651
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          879..>1180
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          <1600..>1872
                     /region_name="Mplasa_alph_rch"
                     /note="helix-rich Mycoplasma protein; TIGR04523"
                     /db_xref="CDD:275316"
     Region          1600..>1676
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          1811..>1869
                     /region_name="Atg16_CCD"
                     /note="Coiled-coiled domain of autophagy-related 16
                     (Atg16) family proteins; cl46300"
                     /db_xref="CDD:480640"
     Region          1904..2288
                     /region_name="McrB"
                     /note="5-methylcytosine-specific restriction endonuclease
                     McrBC, GTP-binding regulatory subunit McrB [Defense
                     mechanisms]; COG1401"
                     /db_xref="CDD:441011"
     CDS             1..2401
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /coded_by="XM_054370395.1:657..7862"
                     /db_xref="GeneID:89797"
                     /db_xref="HGNC:HGNC:15997"
                     /db_xref="MIM:607026"
ORIGIN      
        1 mesvsessqq qkrkpvihgl edqkriytdw anhylaksgh krlikdlqqd vtdgvllaqi
       61 iqvvanekie dingcpknrs qmienidacl nflaakgini qglsaeeirn gnlkailglf
      121 fslsrykqqq qqpqkqhlss plppavsqva gapsqcqagt pqqqvpvtpq apcqphqpap
      181 hqqskaqaem qsrlpgptar vsaagseakt rggsttannr rsqsfnnydk skpvtspppp
      241 psshekepla ssasshpgms dnapaslesg ssstptncst ssaipqpgaa tkpwrsksls
      301 vkhsatvsml svkppgpeap rptpeamkpa pnnqksmlek lklfnskggs kagegpgsrd
      361 tscerletlp sfeeseelea asrmlttvgp assspkialk giaqrtfsra ltnkksslkg
      421 nekekekqqr ekdkekskdl akrasvterl dlkeepkedp sgaavpempk ksskiasfip
      481 kggklnsakk epmapshsgi pkpgmksmpg kspsapapsk egersrsgkl ssglpqqkpq
      541 ldgrhsssss slassegkgp ggttlnhsis sqtvsgsvgt tqttgsntvs vqlpqpqqqy
      601 nhpntatvap flyrsqtdte gnvtaessst gvsvepshft ktgqpaleel tgedpearrl
      661 rtvkniadlr qnleetmssl rgtqvthstl ettfdtnvtt emsgrsilsl tgrptplswr
      721 lgqssprlqa gdapsmgngy ppranasrfi ntesgryvys aplrrqlasr gssvchvdvs
      781 dkagdemdle gismdapgym sdgdvlskni rtdditsgym tdgglglytr rlnrlpdgma
      841 vvretlqrnt slglgdadsw ddsssvssgi sdtidnlstd dintsssiss yantpassrk
      901 nldvqtdaek hsqvernslw sgddvkksdg gsdsgikmep gskwrrnpsd vsdesdksts
      961 gkknpvisqt gswrrgmtaq vgitmprtka sapagalktp gtgktddakv sekgrlspka
     1021 sqvkrspsda grssgdeskk plpsssrtpt anansfgfkk qsgsaaglam itasgvtvts
     1081 rsatlgkipk ssalvsrsag rkssmdgaqn qddgylalss rtnlqyrslp rpsksnsrng
     1141 agnrsstssi dsnissksag lpvpklreps ktalgsslpg lvnqtdkekg issdnesvas
     1201 cnsvkvnpaa qpvsspaqts lqpgakypdv asptlrrlfg gkptkqvpia taenmknsvv
     1261 isnphatmtq qgnldspsgs gvlssgsssp lysknvdlnq splasspssa hsapsnsltw
     1321 gtnassssav skdglgfqsv sslhtscesi dislssggvp shnsstglia sskddsltpf
     1381 vrtnsvkttl sesplsspaa spkfcrstlp rkqdsdphld rntlpkkglr ytptsqlrtq
     1441 edakewlrsh sagglqdtaa nspfssgssv tspsgtrfnf sqlaspttvt qmslsnptml
     1501 rthslsnadg qydpytdsrf rnssmsldek srtmsrsgsf rdgfeeeswe kssvdnfvsr
     1561 lhsslhfslp lfhharyelv hgsslslvss tssvystpee kcqseirklr reldasqekv
     1621 salttqltan ahlvaafeqs lgnmtirlqs ltmtaeqkds elnelrktie llkkqnaaaq
     1681 aaingvintp elnckgngta qsadlrirrq hssdsvssin satshssvgs niesdskkkk
     1741 rknwvnelrs sfkqafgkkk spksasshsd ieemtdsslp sspklphngs tgstpllrns
     1801 hsnslisecm dseaetvmql rnelrdkemk ltdirleals sahqldqlre amnrmqseie
     1861 klkaendrlk sesqgsgcsr apsqvsisas prqsmglsqh slnltestsl dmllddtgec
     1921 sarkeggrhv kivvsfqeem kwkedsrphl fligcigvsg ktkwdvldgv vrrlfkeyii
     1981 hvdpvsqlgl nsdsvlgysi geikrsntse tpellpcgyl vgenttisvt vkglaensld
     2041 slvfeslipk pilqryvsll iehrriilsg psgtgktyla nrlseyivlr egreltdgvi
     2101 atfnvdhkss kelrqylsnl adqcnsenna vdmplviild nlhhvsslge ifngllncky
     2161 hkcpyiigtm nqatsstpnl qlhhnfrwvl canhtepvkg flgrflrrkl meteisgrvr
     2221 nmelvkiidw ipkvwhhlnr fleahsssdv tigprlflsc pidvdgsrvw ftdlwnysii
     2281 pylleaireg lqlygrrapw edpakwvmdt ypwaaspqqh ewppllqlrp edvgfdgysm
     2341 pregstskqm ppsdaegdpl mnmlmrlqea anysspqsyd sdsnsnshhd dildsslest
     2401 l
//
LOCUS       XP_054226371            2395 aa            linear   PRI 05-AUG-2025
DEFINITION  neuron navigator 2 isoform X25 [Homo sapiens].
ACCESSION   XP_054226371
VERSION     XP_054226371.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370396.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2395
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2395
                     /product="neuron navigator 2 isoform X25"
                     /calculated_mol_wt=257552
     Region          77..190
                     /region_name="CH_NAV2"
                     /note="calponin homology (CH) domain found in neuron
                     navigator 2; cd21285"
                     /db_xref="CDD:409134"
     Site            order(87,91,145,147..148,151..152,154,163..171,176,
                     178..179,181..182,185..186,189)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409134"
     Region          <286..715
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          943..>1244
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          <1594..>1866
                     /region_name="Mplasa_alph_rch"
                     /note="helix-rich Mycoplasma protein; TIGR04523"
                     /db_xref="CDD:275316"
     Region          1594..>1670
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          1805..>1863
                     /region_name="Atg16_CCD"
                     /note="Coiled-coiled domain of autophagy-related 16
                     (Atg16) family proteins; cl46300"
                     /db_xref="CDD:480640"
     Region          1898..2282
                     /region_name="McrB"
                     /note="5-methylcytosine-specific restriction endonuclease
                     McrBC, GTP-binding regulatory subunit McrB [Defense
                     mechanisms]; COG1401"
                     /db_xref="CDD:441011"
     CDS             1..2395
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /coded_by="XM_054370396.1:860..8047"
                     /db_xref="GeneID:89797"
                     /db_xref="HGNC:HGNC:15997"
                     /db_xref="MIM:607026"
ORIGIN      
        1 mpailvaskm ksglpkpvhs aapilhvppa ragpqpcylk lgskvevskt typsqiplks
       61 qvlqglqepa geglplrksg svengfdtqi ytdwanhyla ksghkrlikd lqqdvtdgvl
      121 laqiiqvvan ekiedingcp knrsqmieni daclnflaak giniqglsae eirngnlkai
      181 lglffslsry kqqqqqpqkq hlssplppav sqvagapsqc qagtpqqqvp vtpqapcqph
      241 qpaphqqska qaemqsrlpg ptarvsaags eaktrggstt annrrsqsfn nydkskpvts
      301 pppppsshek eplassassh pgmsdnapas lesgssstpt ncstssaipq pgaatkpwrs
      361 kslsvkhsat vsmlsvkppg peaprptpea mkpapnnqks mleklklfns kggskagegp
      421 gsrdtscerl etlpsfeese eleaasrmlt tvgpassspk ialkgiaqrt fsraltnkks
      481 slkgnekeke kqqrekdkek skdlakrasv terldlkeep kedpsgaavp empkksskia
      541 sfipkggkln sakkepmaps hsgipkpgmk smpgkspsap apskegersr sgklssglpq
      601 qkpqldgrhs ssssslasse gkgpggttln hsissqtvsg svgttqttgs ntvsvqlpqp
      661 qqqynhpnta tvapflyrsq tdtegnvtae ssstgvsvep shftktgqpa leeltgedpe
      721 arrlrtvkni adlrqnleet msslrgtqvt hstlettfdt nvttemsgrs ilsltgrptp
      781 lswrlgqssp rlqagdapsm gngypprana srfintesgr yvysaplrrq lasrgssvch
      841 vdvsdkagde mdlegismda pgymsdgdvl sknirtddit sgymtdgglg lytrrlnrlp
      901 dgmavvretl qrntslglgd adswddsssv ssgisdtidn lstddintss sissyantpa
      961 ssrknldvqt daekhsqver nslwsgddvk ksdggsdsgi kmepgskwrr npsdvsdesd
     1021 kstsgkknpv isqtgswrrg mtaqvgitmp rtkasapaga lktpgtgktd dakvsekgrl
     1081 spkasqvkrs psdagrssgd eskkplpsss rtptanansf gfkkqsgsaa glamitasgv
     1141 tvtsrsatlg kipkssalvs rsagrkssmd gaqnqddgyl alssrtnlqy rslprpsksn
     1201 srngagnrss tssidsniss ksaglpvpkl repsktalgs slpglvnqtd kekgissdne
     1261 svascnsvkv npaaqpvssp aqtslqpgak ypdvasptlr rlfggkptkq vpiataenmk
     1321 nsvvisnpha tmtqqgnlds psgsgvlssg sssplysknv dlnqsplass pssahsapsn
     1381 sltwgtnass ssavskdglg fqsvsslhts cesidislss ggvpshnsst gliasskdds
     1441 ltpfvrtnsv kttlserytp tsqlrtqeda kewlrshsag glqdtaansp fssgssvtsp
     1501 sgtrfnfsql aspttvtqms lsnptmlrth slsnadgqyd pytdsrfrns smsldeksrt
     1561 msrsgsfrdg feevhgssls lvsstssvys tpeekcqsei rklrreldas qekvsalttq
     1621 ltanahlvaa feqslgnmti rlqsltmtae qkdselnelr ktiellkkqn aaaqaaingv
     1681 intpelnckg ngtaqsadlr irrqhssdsv ssinsatshs svgsniesds kkkkrknwvn
     1741 elrssfkqaf gkkkspksas shsdieemtd sslpsspklp hngstgstpl lrnshsnsli
     1801 secmdseaet vmqlrnelrd kemkltdirl ealssahqld qlreamnrmq seieklkaen
     1861 drlksesqgs gcsrapsqvs isasprqsmg lsqhslnlte stsldmlldd tgecsarkeg
     1921 grhvkivvsf qeemkwkeds rphlfligci gvsgktkwdv ldgvvrrlfk eyiihvdpvs
     1981 qlglnsdsvl gysigeikrs ntsetpellp cgylvgentt isvtvkglae nsldslvfes
     2041 lipkpilqry vslliehrri ilsgpsgtgk tylanrlsey ivlregrelt dgviatfnvd
     2101 hksskelrqy lsnladqcns ennavdmplv iildnlhhvs slgeifngll nckyhkcpyi
     2161 igtmnqatss tpnlqlhhnf rwvlcanhte pvkgflgrfl rrklmeteis grvrnmelvk
     2221 iidwipkvwh hlnrfleahs ssdvtigprl flscpidvdg srvwftdlwn ysiipyllea
     2281 ireglqlygr rapwedpakw vmdtypwaas pqqhewppll qlrpedvgfd gysmpregst
     2341 skqmppsdae gdplmnmlmr lqeaanyssp qsydsdsnsn shhddildss lestl
//
LOCUS       XP_054226372            2393 aa            linear   PRI 05-AUG-2025
DEFINITION  neuron navigator 2 isoform X26 [Homo sapiens].
ACCESSION   XP_054226372
VERSION     XP_054226372.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370397.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2393
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2393
                     /product="neuron navigator 2 isoform X26"
                     /calculated_mol_wt=258332
     Region          5..118
                     /region_name="CH_NAV2"
                     /note="calponin homology (CH) domain found in neuron
                     navigator 2; cd21285"
                     /db_xref="CDD:409134"
     Site            order(15,19,73,75..76,79..80,82,91..99,104,106..107,
                     109..110,113..114,117)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409134"
     Region          <135..>322
                     /region_name="PRK07003"
                     /note="DNA polymerase III subunit gamma/tau"
                     /db_xref="CDD:235906"
     Region          <214..643
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          871..>1172
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          <1592..>1864
                     /region_name="Mplasa_alph_rch"
                     /note="helix-rich Mycoplasma protein; TIGR04523"
                     /db_xref="CDD:275316"
     Region          1592..>1668
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          <1811..>1866
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          1896..2280
                     /region_name="McrB"
                     /note="5-methylcytosine-specific restriction endonuclease
                     McrBC, GTP-binding regulatory subunit McrB [Defense
                     mechanisms]; COG1401"
                     /db_xref="CDD:441011"
     CDS             1..2393
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /coded_by="XM_054370397.1:300..7481"
                     /db_xref="GeneID:89797"
                     /db_xref="HGNC:HGNC:15997"
                     /db_xref="MIM:607026"
ORIGIN      
        1 msvmlwrweq nnttmkliyt dwanhylaks ghkrlikdlq qdvtdgvlla qiiqvvanek
       61 iedingcpkn rsqmienida clnflaakgi niqglsaeei rngnlkailg lffslsrykq
      121 qqqqpqkqhl ssplppavsq vagapsqcqa gtpqqqvpvt pqapcqphqp aphqqskaqa
      181 emqsrlpgpt arvsaagsea ktrggsttan nrrsqsfnny dkskpvtspp pppsshekep
      241 lassasshpg msdnapasle sgssstptnc stssaipqpg aatkpwrsks lsvkhsatvs
      301 mlsvkppgpe aprptpeamk papnnqksml eklklfnskg gskagegpgs rdtscerlet
      361 lpsfeeseel eaasrmlttv gpassspkia lkgiaqrtfs raltnkkssl kgnekekekq
      421 qrekdkeksk dlakrasvte rldlkeepke dpsgaavpem pkksskiasf ipkggklnsa
      481 kkepmapshs gipkpgmksm pgkspsapap skegersrsg klssglpqqk pqldgrhsss
      541 ssslassegk gpggttlnhs issqtvsgsv gttqttgsnt vsvqlpqpqq qynhpntatv
      601 apflyrsqtd tegnvtaess stgvsvepsh ftktgqpale eltgedpear rlrtvkniad
      661 lrqnleetms slrgtqvths tlettfdtnv ttemsgrsil sltgrptpls wrlgqssprl
      721 qagdapsmgn gyppranasr fintesgryv ysaplrrqla srgssvchvd vsdkagdemd
      781 legismdapg ymsdgdvlsk nirtdditsg ymtdgglgly trrlnrlpdg mavvretlqr
      841 ntslglgdad swddsssvss gisdtidnls tddintsssi ssyantpass rknldvqtda
      901 ekhsqverns lwsgddvkks dggsdsgikm epgskwrrnp sdvsdesdks tsgkknpvis
      961 qtgswrrgmt aqvgitmprt kasapagalk tpgtgktdda kvsekgrlsp kasqvkrsps
     1021 dagrssgdes kkplpsssrt ptanansfgf kkqsgsaagl amitasgvtv tsrsatlgki
     1081 pkssalvsrs agrkssmdga qnqddgylal ssrtnlqyrs lprpsksnsr ngagnrssts
     1141 sidsnissks aglpvpklre psktalgssl pglvnqtdke kgissdnesv ascnsvkvnp
     1201 aaqpvsspaq tslqpgakyp dvasptlrrl fggkptkqvp iataenmkns vvisnphatm
     1261 tqqgnldsps gsgvlssgss splysknvdl nqsplassps sahsapsnsl twgtnassss
     1321 avskdglgfq svsslhtsce sidislssgg vpshnsstgl iasskddslt pfvrtnsvkt
     1381 tlsesplssp aaspkfcrst lprkqdsdph ldrntlpkkg lrytptsqlr tqedakewlr
     1441 shsagglqdt aanspfssgs svtspsgtrf nfsqlasptt vtqmslsnpt mlrthslsna
     1501 dgqydpytds rfrnssmsld eksrtmsrsg sfrdgfeees wekssvdnfv srlhsslhfs
     1561 lplfhharye lvhgsslslv sstssvystp eekcqseirk lrreldasqe kvsalttqlt
     1621 anahlvaafe qslgnmtirl qsltmtaeqk dselnelrkt iellkkqnaa aqaaingvin
     1681 tpelnckgng taqsadlrir rqhssdsvss insatshssv gsniesdskk kkrknwvnel
     1741 rssfkqafgk kkspksassh sdieemtdss lpsspklphn gstgstpllr nshsnslise
     1801 cmdseaetvm qlrnelrdke mkltdirlea lssahqldql reamnrmqse ieklkaendr
     1861 lksesqgsgc srapsqvsis asprqsmgls qhslnltest sldmllddtg ecsarkeggr
     1921 hvkivvsfqe emkwkedsrp hlfligcigv sgktkwdvld gvvrrlfkey iihvdpvsql
     1981 glnsdsvlgy sigeikrsnt setpellpcg ylvgenttis vtvkglaens ldslvfesli
     2041 pkpilqryvs lliehrriil sgpsgtgkty lanrlseyiv lregreltdg viatfnvdhk
     2101 sskelrqyls nladqcnsen navdmplvii ldnlhhvssl geifngllnc kyhkcpyiig
     2161 tmnqatsstp nlqlhhnfrw vlcanhtepv kgflgrflrr klmeteisgr vrnmelvkii
     2221 dwipkvwhhl nrfleahsss dvtigprlfl scpidvdgsr vwftdlwnys iipylleair
     2281 eglqlygrra pwedpakwvm dtypwaaspq qhewppllql rpedvgfdgy smpregstsk
     2341 qmppsdaegd plmnmlmrlq eaanysspqs ydsdsnsnsh hddildssle stl
//
LOCUS       XP_054226373            2392 aa            linear   PRI 05-AUG-2025
DEFINITION  neuron navigator 2 isoform X27 [Homo sapiens].
ACCESSION   XP_054226373
VERSION     XP_054226373.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370398.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2392
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2392
                     /product="neuron navigator 2 isoform X27"
                     /calculated_mol_wt=257209
     Region          77..190
                     /region_name="CH_NAV2"
                     /note="calponin homology (CH) domain found in neuron
                     navigator 2; cd21285"
                     /db_xref="CDD:409134"
     Site            order(87,91,145,147..148,151..152,154,163..171,176,
                     178..179,181..182,185..186,189)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409134"
     Region          <286..715
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          943..>1244
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          1594..>1670
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          1802..>1860
                     /region_name="Atg16_CCD"
                     /note="Coiled-coiled domain of autophagy-related 16
                     (Atg16) family proteins; cl46300"
                     /db_xref="CDD:480640"
     Region          1895..2279
                     /region_name="McrB"
                     /note="5-methylcytosine-specific restriction endonuclease
                     McrBC, GTP-binding regulatory subunit McrB [Defense
                     mechanisms]; COG1401"
                     /db_xref="CDD:441011"
     CDS             1..2392
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /coded_by="XM_054370398.1:860..8038"
                     /db_xref="GeneID:89797"
                     /db_xref="HGNC:HGNC:15997"
                     /db_xref="MIM:607026"
ORIGIN      
        1 mpailvaskm ksglpkpvhs aapilhvppa ragpqpcylk lgskvevskt typsqiplks
       61 qvlqglqepa geglplrksg svengfdtqi ytdwanhyla ksghkrlikd lqqdvtdgvl
      121 laqiiqvvan ekiedingcp knrsqmieni daclnflaak giniqglsae eirngnlkai
      181 lglffslsry kqqqqqpqkq hlssplppav sqvagapsqc qagtpqqqvp vtpqapcqph
      241 qpaphqqska qaemqsrlpg ptarvsaags eaktrggstt annrrsqsfn nydkskpvts
      301 pppppsshek eplassassh pgmsdnapas lesgssstpt ncstssaipq pgaatkpwrs
      361 kslsvkhsat vsmlsvkppg peaprptpea mkpapnnqks mleklklfns kggskagegp
      421 gsrdtscerl etlpsfeese eleaasrmlt tvgpassspk ialkgiaqrt fsraltnkks
      481 slkgnekeke kqqrekdkek skdlakrasv terldlkeep kedpsgaavp empkksskia
      541 sfipkggkln sakkepmaps hsgipkpgmk smpgkspsap apskegersr sgklssglpq
      601 qkpqldgrhs ssssslasse gkgpggttln hsissqtvsg svgttqttgs ntvsvqlpqp
      661 qqqynhpnta tvapflyrsq tdtegnvtae ssstgvsvep shftktgqpa leeltgedpe
      721 arrlrtvkni adlrqnleet msslrgtqvt hstlettfdt nvttemsgrs ilsltgrptp
      781 lswrlgqssp rlqagdapsm gngypprana srfintesgr yvysaplrrq lasrgssvch
      841 vdvsdkagde mdlegismda pgymsdgdvl sknirtddit sgymtdgglg lytrrlnrlp
      901 dgmavvretl qrntslglgd adswddsssv ssgisdtidn lstddintss sissyantpa
      961 ssrknldvqt daekhsqver nslwsgddvk ksdggsdsgi kmepgskwrr npsdvsdesd
     1021 kstsgkknpv isqtgswrrg mtaqvgitmp rtkasapaga lktpgtgktd dakvsekgrl
     1081 spkasqvkrs psdagrssgd eskkplpsss rtptanansf gfkkqsgsaa glamitasgv
     1141 tvtsrsatlg kipkssalvs rsagrkssmd gaqnqddgyl alssrtnlqy rslprpsksn
     1201 srngagnrss tssidsniss ksaglpvpkl repsktalgs slpglvnqtd kekgissdne
     1261 svascnsvkv npaaqpvssp aqtslqpgak ypdvasptlr rlfggkptkq vpiataenmk
     1321 nsvvisnpha tmtqqgnlds psgsgvlssg sssplysknv dlnqsplass pssahsapsn
     1381 sltwgtnass ssavskdglg fqsvsslhts cesidislss ggvpshnsst gliasskdds
     1441 ltpfvrtnsv kttlserytp tsqlrtqeda kewlrshsag glqdtaansp fssgssvtsp
     1501 sgtrfnfsql aspttvtqms lsnptmlrth slsnadgqyd pytdsrfrns smsldeksrt
     1561 msrsgsfrdg feevhgssls lvsstssvys tpeekcqsei rklrreldas qekvsalttq
     1621 ltanahlvaa feqslgnmti rlqsltmtae qkdselnelr ktiellkkqn aaaqaaingv
     1681 intpelnckg ngtaqsadlr irrqhssdsv ssinsatshs svgsniesds kkkkrknwlr
     1741 ssfkqafgkk kspksasshs dieemtdssl psspklphng stgstpllrn shsnslisec
     1801 mdseaetvmq lrnelrdkem kltdirleal ssahqldqlr eamnrmqsei eklkaendrl
     1861 ksesqgsgcs rapsqvsisa sprqsmglsq hslnltests ldmllddtge csarkeggrh
     1921 vkivvsfqee mkwkedsrph lfligcigvs gktkwdvldg vvrrlfkeyi ihvdpvsqlg
     1981 lnsdsvlgys igeikrsnts etpellpcgy lvgenttisv tvkglaensl dslvfeslip
     2041 kpilqryvsl liehrriils gpsgtgktyl anrlseyivl regreltdgv iatfnvdhks
     2101 skelrqylsn ladqcnsenn avdmplviil dnlhhvsslg eifngllnck yhkcpyiigt
     2161 mnqatsstpn lqlhhnfrwv lcanhtepvk gflgrflrrk lmeteisgrv rnmelvkiid
     2221 wipkvwhhln rfleahsssd vtigprlfls cpidvdgsrv wftdlwnysi ipylleaire
     2281 glqlygrrap wedpakwvmd typwaaspqq hewppllqlr pedvgfdgys mpregstskq
     2341 mppsdaegdp lmnmlmrlqe aanysspqsy dsdsnsnshh ddildssles tl
//
LOCUS       XP_054226374            2388 aa            linear   PRI 05-AUG-2025
DEFINITION  neuron navigator 2 isoform X28 [Homo sapiens].
ACCESSION   XP_054226374
VERSION     XP_054226374.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370399.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2388
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2388
                     /product="neuron navigator 2 isoform X28"
                     /calculated_mol_wt=257287
     Region          15..126
                     /region_name="CH_NAV2"
                     /note="calponin homology (CH) domain found in neuron
                     navigator 2; cd21285"
                     /db_xref="CDD:409134"
     Site            order(23,27,81,83..84,87..88,90,99..107,112,114..115,
                     117..118,121..122,125)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409134"
     Region          <245..674
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          902..>1203
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          1590..>1666
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          1798..>1856
                     /region_name="Atg16_CCD"
                     /note="Coiled-coiled domain of autophagy-related 16
                     (Atg16) family proteins; cl46300"
                     /db_xref="CDD:480640"
     Region          1891..2275
                     /region_name="McrB"
                     /note="5-methylcytosine-specific restriction endonuclease
                     McrBC, GTP-binding regulatory subunit McrB [Defense
                     mechanisms]; COG1401"
                     /db_xref="CDD:441011"
     CDS             1..2388
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /coded_by="XM_054370399.1:657..7823"
                     /db_xref="GeneID:89797"
                     /db_xref="HGNC:HGNC:15997"
                     /db_xref="MIM:607026"
ORIGIN      
        1 mesvsessqq qkrkpvihgl edqkriytdw anhylaksgh krlikdlqqd vtdgvllaqi
       61 iqvvanekie dingcpknrs qmienidacl nflaakgini qglsaeeirn gnlkailglf
      121 fslsrykqqq qqpqkqhlss plppavsqva gapsqcqagt pqqqvpvtpq apcqphqpap
      181 hqqskaqaem qssasskdss qskiirftlg qkkisrlpgp tarvsaagse aktrggstta
      241 nnrrsqsfnn ydkskpvtsp ppppssheke plassasshp gmsdnapasl esgssstptn
      301 cstssaipqp gaatkpwrsk slsvkhsatv smlsvkppgp eaprptpeam kpapnnqksm
      361 leklklfnsk ggskagegpg srdtscerle tlpsfeesee leaasrmltt vgpassspki
      421 alkgiaqrtf sraltnkkss lkgnekekek qqrekdkeks kdlakrasvt erldlkeepk
      481 edpsgaavpe mpkksskias fipkggklns akkepmapsh sgipkpgmks mpgkspsapa
      541 pskegersrs gklssglpqq kpqldgrhss sssslasseg kgpggttlnh sissqtvsgs
      601 vgttqttgsn tvsvqlpqpq qqynhpntat vapflyrsqt dtegnvtaes sstgvsveps
      661 hftktgqpal eeltgedpea rrlrtvknia dlrqnleetm sslrgtqvth stlettfdtn
      721 vttemsgrsi lsltgrptpl swrlgqsspr lqagdapsmg ngyppranas rfintesgry
      781 vysaplrrql asrgssvchv dvsdkagdem dlegismdap gymsdgdvls knirtddits
      841 gymtdgglgl ytrrlnrlpd gmavvretlq rntslglgda dswddsssvs sgisdtidnl
      901 stddintsss issyantpas srknldvqtd aekhsqvern slwsgddvkk sdggsdsgik
      961 mepgskwrrn psdvsdesdk stsgkknpvi sqtgswrrgm taqvgitmpr tkasapagal
     1021 ktpgtgktdd akvsekgrls pkasqvkrsp sdagrssgde skkplpsssr tptanansfg
     1081 fkkqsgsaag lamitasgvt vtsrsatlgk ipkssalvsr sagrkssmdg aqnqddgyla
     1141 lssrtnlqyr slprpsksns rngagnrsst ssidsnissk saglpvpklr epsktalgss
     1201 lpglvnqtdk ekgissdnes vascnsvkvn paaqpvsspa qtslqpgaky pdvasptlrr
     1261 lfggkptkqv piataenmkn svvisnphat mtqqgnldsp sgsgvlssgs ssplysknvd
     1321 lnqsplassp ssahsapsns ltwgtnasss savskdglgf qsvsslhtsc esidislssg
     1381 gvpshnsstg liasskddsl tpfvrtnsvk ttlsesplss paaspkfcrs tlprkqdsdp
     1441 hldrntlpkk glrytptsql rtqedakewl rshsagglqd taanspfssg ssvtspsgtr
     1501 fnfsqlaspt tvtqmslsnp tmlrthslsn adgqydpytd srfrnssmsl deksrtmsrs
     1561 gsfrdgfeev hgsslslvss tssvystpee kcqseirklr reldasqekv salttqltan
     1621 ahlvaafeqs lgnmtirlqs ltmtaeqkds elnelrktie llkkqnaaaq aaingvintp
     1681 elnckgngta qsadlrirrq hssdsvssin satshssvgs niesdskkkk rknwlrssfk
     1741 qafgkkkspk sasshsdiee mtdsslpssp klphngstgs tpllrnshsn slisecmdse
     1801 aetvmqlrne lrdkemkltd irlealssah qldqlreamn rmqseieklk aendrlkses
     1861 qgsgcsraps qvsisasprq smglsqhsln ltestsldml lddtgecsar keggrhvkiv
     1921 vsfqeemkwk edsrphlfli gcigvsgktk wdvldgvvrr lfkeyiihvd pvsqlglnsd
     1981 svlgysigei krsntsetpe llpcgylvge nttisvtvkg laensldslv feslipkpil
     2041 qryvsllieh rriilsgpsg tgktylanrl seyivlregr eltdgviatf nvdhksskel
     2101 rqylsnladq cnsennavdm plviildnlh hvsslgeifn gllnckyhkc pyiigtmnqa
     2161 tsstpnlqlh hnfrwvlcan htepvkgflg rflrrklmet eisgrvrnme lvkiidwipk
     2221 vwhhlnrfle ahsssdvtig prlflscpid vdgsrvwftd lwnysiipyl leaireglql
     2281 ygrrapwedp akwvmdtypw aaspqqhewp pllqlrpedv gfdgysmpre gstskqmpps
     2341 daegdplmnm lmrlqeaany sspqsydsds nsnshhddil dsslestl
//
LOCUS       XP_054226375            2361 aa            linear   PRI 05-AUG-2025
DEFINITION  neuron navigator 2 isoform X29 [Homo sapiens].
ACCESSION   XP_054226375
VERSION     XP_054226375.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370400.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2361
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2361
                     /product="neuron navigator 2 isoform X29"
                     /calculated_mol_wt=254718
     Region          15..126
                     /region_name="CH_NAV2"
                     /note="calponin homology (CH) domain found in neuron
                     navigator 2; cd21285"
                     /db_xref="CDD:409134"
     Site            order(23,27,81,83..84,87..88,90,99..107,112,114..115,
                     117..118,121..122,125)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409134"
     Region          <222..651
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          879..>1180
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          1563..>1639
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          1771..>1829
                     /region_name="Atg16_CCD"
                     /note="Coiled-coiled domain of autophagy-related 16
                     (Atg16) family proteins; cl46300"
                     /db_xref="CDD:480640"
     Region          1864..2248
                     /region_name="McrB"
                     /note="5-methylcytosine-specific restriction endonuclease
                     McrBC, GTP-binding regulatory subunit McrB [Defense
                     mechanisms]; COG1401"
                     /db_xref="CDD:441011"
     CDS             1..2361
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /coded_by="XM_054370400.1:771..7856"
                     /db_xref="GeneID:89797"
                     /db_xref="HGNC:HGNC:15997"
                     /db_xref="MIM:607026"
ORIGIN      
        1 mesvsessqq qkrkpvihgl edqkriytdw anhylaksgh krlikdlqqd vtdgvllaqi
       61 iqvvanekie dingcpknrs qmienidacl nflaakgini qglsaeeirn gnlkailglf
      121 fslsrykqqq qqpqkqhlss plppavsqva gapsqcqagt pqqqvpvtpq apcqphqpap
      181 hqqskaqaem qsrlpgptar vsaagseakt rggsttannr rsqsfnnydk skpvtspppp
      241 psshekepla ssasshpgms dnapaslesg ssstptncst ssaipqpgaa tkpwrsksls
      301 vkhsatvsml svkppgpeap rptpeamkpa pnnqksmlek lklfnskggs kagegpgsrd
      361 tscerletlp sfeeseelea asrmlttvgp assspkialk giaqrtfsra ltnkksslkg
      421 nekekekqqr ekdkekskdl akrasvterl dlkeepkedp sgaavpempk ksskiasfip
      481 kggklnsakk epmapshsgi pkpgmksmpg kspsapapsk egersrsgkl ssglpqqkpq
      541 ldgrhsssss slassegkgp ggttlnhsis sqtvsgsvgt tqttgsntvs vqlpqpqqqy
      601 nhpntatvap flyrsqtdte gnvtaessst gvsvepshft ktgqpaleel tgedpearrl
      661 rtvkniadlr qnleetmssl rgtqvthstl ettfdtnvtt emsgrsilsl tgrptplswr
      721 lgqssprlqa gdapsmgngy ppranasrfi ntesgryvys aplrrqlasr gssvchvdvs
      781 dkagdemdle gismdapgym sdgdvlskni rtdditsgym tdgglglytr rlnrlpdgma
      841 vvretlqrnt slglgdadsw ddsssvssgi sdtidnlstd dintsssiss yantpassrk
      901 nldvqtdaek hsqvernslw sgddvkksdg gsdsgikmep gskwrrnpsd vsdesdksts
      961 gkknpvisqt gswrrgmtaq vgitmprtka sapagalktp gtgktddakv sekgrlspka
     1021 sqvkrspsda grssgdeskk plpsssrtpt anansfgfkk qsgsaaglam itasgvtvts
     1081 rsatlgkipk ssalvsrsag rkssmdgaqn qddgylalss rtnlqyrslp rpsksnsrng
     1141 agnrsstssi dsnissksag lpvpklreps ktalgsslpg lvnqtdkekg issdnesvas
     1201 cnsvkvnpaa qpvsspaqts lqpgakypdv asptlrrlfg gkptkqvpia taenmknsvv
     1261 isnphatmtq qgnldspsgs gvlssgsssp lysknvdlnq splasspssa hsapsnsltw
     1321 gtnassssav skdglgfqsv sslhtscesi dislssggvp shnsstglia sskddsltpf
     1381 vrtnsvkttl serytptsql rtqedakewl rshsagglqd taanspfssg ssvtspsgtr
     1441 fnfsqlaspt tvtqmslsnp tmlrthslsn adgqydpytd srfrnssmsl deksrtmsrs
     1501 gsfrdgfeee swekssvdnf vsrlhsslhf slplfhhary elvhgsslsl vsstssvyst
     1561 peekcqseir klrreldasq ekvsalttql tanahlvaaf eqslgnmtir lqsltmtaeq
     1621 kdselnelrk tiellkkqna aaqaaingvi ntpelnckgn gtaqsadlri rrqhssdsvs
     1681 sinsatshss vgsniesdsk kkkrknwlrs sfkqafgkkk spksasshsd ieemtdsslp
     1741 sspklphngs tgstpllrns hsnslisecm dseaetvmql rnelrdkemk ltdirleals
     1801 sahqldqlre amnrmqseie klkaendrlk sesqgsgcsr apsqvsisas prqsmglsqh
     1861 slnltestsl dmllddtgec sarkeggrhv kivvsfqeem kwkedsrphl fligcigvsg
     1921 ktkwdvldgv vrrlfkeyii hvdpvsqlgl nsdsvlgysi geikrsntse tpellpcgyl
     1981 vgenttisvt vkglaensld slvfeslipk pilqryvsll iehrriilsg psgtgktyla
     2041 nrlseyivlr egreltdgvi atfnvdhkss kelrqylsnl adqcnsenna vdmplviild
     2101 nlhhvsslge ifngllncky hkcpyiigtm nqatsstpnl qlhhnfrwvl canhtepvkg
     2161 flgrflrrkl meteisgrvr nmelvkiidw ipkvwhhlnr fleahsssdv tigprlflsc
     2221 pidvdgsrvw ftdlwnysii pylleaireg lqlygrrapw edpakwvmdt ypwaaspqqh
     2281 ewppllqlrp edvgfdgysm pregstskqm ppsdaegdpl mnmlmrlqea anysspqsyd
     2341 sdsnsnshhd dildsslest l
//
LOCUS       XP_054226376            2356 aa            linear   PRI 05-AUG-2025
DEFINITION  neuron navigator 2 isoform X30 [Homo sapiens].
ACCESSION   XP_054226376
VERSION     XP_054226376.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370401.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2356
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2356
                     /product="neuron navigator 2 isoform X30"
                     /calculated_mol_wt=254304
     Region          5..118
                     /region_name="CH_NAV2"
                     /note="calponin homology (CH) domain found in neuron
                     navigator 2; cd21285"
                     /db_xref="CDD:409134"
     Site            order(15,19,73,75..76,79..80,82,91..99,104,106..107,
                     109..110,113..114,117)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409134"
     Region          <214..643
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          871..>1172
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          <1555..>1827
                     /region_name="Mplasa_alph_rch"
                     /note="helix-rich Mycoplasma protein; TIGR04523"
                     /db_xref="CDD:275316"
     Region          1555..>1631
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          <1774..>1829
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          1859..2243
                     /region_name="McrB"
                     /note="5-methylcytosine-specific restriction endonuclease
                     McrBC, GTP-binding regulatory subunit McrB [Defense
                     mechanisms]; COG1401"
                     /db_xref="CDD:441011"
     CDS             1..2356
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /coded_by="XM_054370401.1:300..7370"
                     /db_xref="GeneID:89797"
                     /db_xref="HGNC:HGNC:15997"
                     /db_xref="MIM:607026"
ORIGIN      
        1 msvmlwrweq nnttmkliyt dwanhylaks ghkrlikdlq qdvtdgvlla qiiqvvanek
       61 iedingcpkn rsqmienida clnflaakgi niqglsaeei rngnlkailg lffslsrykq
      121 qqqqpqkqhl ssplppavsq vagapsqcqa gtpqqqvpvt pqapcqphqp aphqqskaqa
      181 emqsrlpgpt arvsaagsea ktrggsttan nrrsqsfnny dkskpvtspp pppsshekep
      241 lassasshpg msdnapasle sgssstptnc stssaipqpg aatkpwrsks lsvkhsatvs
      301 mlsvkppgpe aprptpeamk papnnqksml eklklfnskg gskagegpgs rdtscerlet
      361 lpsfeeseel eaasrmlttv gpassspkia lkgiaqrtfs raltnkkssl kgnekekekq
      421 qrekdkeksk dlakrasvte rldlkeepke dpsgaavpem pkksskiasf ipkggklnsa
      481 kkepmapshs gipkpgmksm pgkspsapap skegersrsg klssglpqqk pqldgrhsss
      541 ssslassegk gpggttlnhs issqtvsgsv gttqttgsnt vsvqlpqpqq qynhpntatv
      601 apflyrsqtd tegnvtaess stgvsvepsh ftktgqpale eltgedpear rlrtvkniad
      661 lrqnleetms slrgtqvths tlettfdtnv ttemsgrsil sltgrptpls wrlgqssprl
      721 qagdapsmgn gyppranasr fintesgryv ysaplrrqla srgssvchvd vsdkagdemd
      781 legismdapg ymsdgdvlsk nirtdditsg ymtdgglgly trrlnrlpdg mavvretlqr
      841 ntslglgdad swddsssvss gisdtidnls tddintsssi ssyantpass rknldvqtda
      901 ekhsqverns lwsgddvkks dggsdsgikm epgskwrrnp sdvsdesdks tsgkknpvis
      961 qtgswrrgmt aqvgitmprt kasapagalk tpgtgktdda kvsekgrlsp kasqvkrsps
     1021 dagrssgdes kkplpsssrt ptanansfgf kkqsgsaagl amitasgvtv tsrsatlgki
     1081 pkssalvsrs agrkssmdga qnqddgylal ssrtnlqyrs lprpsksnsr ngagnrssts
     1141 sidsnissks aglpvpklre psktalgssl pglvnqtdke kgissdnesv ascnsvkvnp
     1201 aaqpvsspaq tslqpgakyp dvasptlrrl fggkptkqvp iataenmkns vvisnphatm
     1261 tqqgnldsps gsgvlssgss splysknvdl nqsplassps sahsapsnsl twgtnassss
     1321 avskdglgfq svsslhtsce sidislssgg vpshnsstgl iasskddslt pfvrtnsvkt
     1381 tlserytpts qlrtqedake wlrshsaggl qdtaanspfs sgssvtspsg trfnfsqlas
     1441 pttvtqmsls nptmlrthsl snadgqydpy tdsrfrnssm sldeksrtms rsgsfrdgfe
     1501 eeswekssvd nfvsrlhssl hfslplfhha ryelvhgssl slvsstssvy stpeekcqse
     1561 irklrrelda sqekvsaltt qltanahlva afeqslgnmt irlqsltmta eqkdselnel
     1621 rktiellkkq naaaqaaing vintpelnck gngtaqsadl rirrqhssds vssinsatsh
     1681 ssvgsniesd skkkkrknwv nelrssfkqa fgkkkspksa sshsdieemt dsslpsspkl
     1741 phngstgstp llrnshsnsl isecmdseae tvmqlrnelr dkemkltdir lealssahql
     1801 dqlreamnrm qseieklkae ndrlksesqg sgcsrapsqv sisasprqsm glsqhslnlt
     1861 estsldmlld dtgecsarke ggrhvkivvs fqeemkwked srphlfligc igvsgktkwd
     1921 vldgvvrrlf keyiihvdpv sqlglnsdsv lgysigeikr sntsetpell pcgylvgent
     1981 tisvtvkgla ensldslvfe slipkpilqr yvslliehrr iilsgpsgtg ktylanrlse
     2041 yivlregrel tdgviatfnv dhksskelrq ylsnladqcn sennavdmpl viildnlhhv
     2101 sslgeifngl lnckyhkcpy iigtmnqats stpnlqlhhn frwvlcanht epvkgflgrf
     2161 lrrklmetei sgrvrnmelv kiidwipkvw hhlnrfleah sssdvtigpr lflscpidvd
     2221 gsrvwftdlw nysiipylle aireglqlyg rrapwedpak wvmdtypwaa spqqhewppl
     2281 lqlrpedvgf dgysmpregs tskqmppsda egdplmnmlm rlqeaanyss pqsydsdsns
     2341 nshhddilds slestl
//
LOCUS       XP_054226377            2353 aa            linear   PRI 05-AUG-2025
DEFINITION  neuron navigator 2 isoform X31 [Homo sapiens].
ACCESSION   XP_054226377
VERSION     XP_054226377.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370402.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2353
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2353
                     /product="neuron navigator 2 isoform X31"
                     /calculated_mol_wt=253961
     Region          5..118
                     /region_name="CH_NAV2"
                     /note="calponin homology (CH) domain found in neuron
                     navigator 2; cd21285"
                     /db_xref="CDD:409134"
     Site            order(15,19,73,75..76,79..80,82,91..99,104,106..107,
                     109..110,113..114,117)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409134"
     Region          <214..643
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          871..>1172
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          <1555..>1824
                     /region_name="Mplasa_alph_rch"
                     /note="helix-rich Mycoplasma protein; TIGR04523"
                     /db_xref="CDD:275316"
     Region          1555..>1631
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          <1771..>1826
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          1856..2240
                     /region_name="McrB"
                     /note="5-methylcytosine-specific restriction endonuclease
                     McrBC, GTP-binding regulatory subunit McrB [Defense
                     mechanisms]; COG1401"
                     /db_xref="CDD:441011"
     CDS             1..2353
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /coded_by="XM_054370402.1:300..7361"
                     /db_xref="GeneID:89797"
                     /db_xref="HGNC:HGNC:15997"
                     /db_xref="MIM:607026"
ORIGIN      
        1 msvmlwrweq nnttmkliyt dwanhylaks ghkrlikdlq qdvtdgvlla qiiqvvanek
       61 iedingcpkn rsqmienida clnflaakgi niqglsaeei rngnlkailg lffslsrykq
      121 qqqqpqkqhl ssplppavsq vagapsqcqa gtpqqqvpvt pqapcqphqp aphqqskaqa
      181 emqsrlpgpt arvsaagsea ktrggsttan nrrsqsfnny dkskpvtspp pppsshekep
      241 lassasshpg msdnapasle sgssstptnc stssaipqpg aatkpwrsks lsvkhsatvs
      301 mlsvkppgpe aprptpeamk papnnqksml eklklfnskg gskagegpgs rdtscerlet
      361 lpsfeeseel eaasrmlttv gpassspkia lkgiaqrtfs raltnkkssl kgnekekekq
      421 qrekdkeksk dlakrasvte rldlkeepke dpsgaavpem pkksskiasf ipkggklnsa
      481 kkepmapshs gipkpgmksm pgkspsapap skegersrsg klssglpqqk pqldgrhsss
      541 ssslassegk gpggttlnhs issqtvsgsv gttqttgsnt vsvqlpqpqq qynhpntatv
      601 apflyrsqtd tegnvtaess stgvsvepsh ftktgqpale eltgedpear rlrtvkniad
      661 lrqnleetms slrgtqvths tlettfdtnv ttemsgrsil sltgrptpls wrlgqssprl
      721 qagdapsmgn gyppranasr fintesgryv ysaplrrqla srgssvchvd vsdkagdemd
      781 legismdapg ymsdgdvlsk nirtdditsg ymtdgglgly trrlnrlpdg mavvretlqr
      841 ntslglgdad swddsssvss gisdtidnls tddintsssi ssyantpass rknldvqtda
      901 ekhsqverns lwsgddvkks dggsdsgikm epgskwrrnp sdvsdesdks tsgkknpvis
      961 qtgswrrgmt aqvgitmprt kasapagalk tpgtgktdda kvsekgrlsp kasqvkrsps
     1021 dagrssgdes kkplpsssrt ptanansfgf kkqsgsaagl amitasgvtv tsrsatlgki
     1081 pkssalvsrs agrkssmdga qnqddgylal ssrtnlqyrs lprpsksnsr ngagnrssts
     1141 sidsnissks aglpvpklre psktalgssl pglvnqtdke kgissdnesv ascnsvkvnp
     1201 aaqpvsspaq tslqpgakyp dvasptlrrl fggkptkqvp iataenmkns vvisnphatm
     1261 tqqgnldsps gsgvlssgss splysknvdl nqsplassps sahsapsnsl twgtnassss
     1321 avskdglgfq svsslhtsce sidislssgg vpshnsstgl iasskddslt pfvrtnsvkt
     1381 tlserytpts qlrtqedake wlrshsaggl qdtaanspfs sgssvtspsg trfnfsqlas
     1441 pttvtqmsls nptmlrthsl snadgqydpy tdsrfrnssm sldeksrtms rsgsfrdgfe
     1501 eeswekssvd nfvsrlhssl hfslplfhha ryelvhgssl slvsstssvy stpeekcqse
     1561 irklrrelda sqekvsaltt qltanahlva afeqslgnmt irlqsltmta eqkdselnel
     1621 rktiellkkq naaaqaaing vintpelnck gngtaqsadl rirrqhssds vssinsatsh
     1681 ssvgsniesd skkkkrknwl rssfkqafgk kkspksassh sdieemtdss lpsspklphn
     1741 gstgstpllr nshsnslise cmdseaetvm qlrnelrdke mkltdirlea lssahqldql
     1801 reamnrmqse ieklkaendr lksesqgsgc srapsqvsis asprqsmgls qhslnltest
     1861 sldmllddtg ecsarkeggr hvkivvsfqe emkwkedsrp hlfligcigv sgktkwdvld
     1921 gvvrrlfkey iihvdpvsql glnsdsvlgy sigeikrsnt setpellpcg ylvgenttis
     1981 vtvkglaens ldslvfesli pkpilqryvs lliehrriil sgpsgtgkty lanrlseyiv
     2041 lregreltdg viatfnvdhk sskelrqyls nladqcnsen navdmplvii ldnlhhvssl
     2101 geifngllnc kyhkcpyiig tmnqatsstp nlqlhhnfrw vlcanhtepv kgflgrflrr
     2161 klmeteisgr vrnmelvkii dwipkvwhhl nrfleahsss dvtigprlfl scpidvdgsr
     2221 vwftdlwnys iipylleair eglqlygrra pwedpakwvm dtypwaaspq qhewppllql
     2281 rpedvgfdgy smpregstsk qmppsdaegd plmnmlmrlq eaanysspqs ydsdsnsnsh
     2341 hddildssle stl
//
LOCUS       XP_054226378            2343 aa            linear   PRI 05-AUG-2025
DEFINITION  neuron navigator 2 isoform X32 [Homo sapiens].
ACCESSION   XP_054226378
VERSION     XP_054226378.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370403.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2343
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2343
                     /product="neuron navigator 2 isoform X32"
                     /calculated_mol_wt=252452
     Region          15..126
                     /region_name="CH_NAV2"
                     /note="calponin homology (CH) domain found in neuron
                     navigator 2; cd21285"
                     /db_xref="CDD:409134"
     Site            order(23,27,81,83..84,87..88,90,99..107,112,114..115,
                     117..118,121..122,125)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409134"
     Region          <143..>330
                     /region_name="PRK07003"
                     /note="DNA polymerase III subunit gamma/tau"
                     /db_xref="CDD:235906"
     Region          <222..651
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          879..>1180
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          1545..>1621
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          1753..>1811
                     /region_name="Atg16_CCD"
                     /note="Coiled-coiled domain of autophagy-related 16
                     (Atg16) family proteins; cl46300"
                     /db_xref="CDD:480640"
     Region          1846..2230
                     /region_name="McrB"
                     /note="5-methylcytosine-specific restriction endonuclease
                     McrBC, GTP-binding regulatory subunit McrB [Defense
                     mechanisms]; COG1401"
                     /db_xref="CDD:441011"
     CDS             1..2343
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /coded_by="XM_054370403.1:657..7688"
                     /db_xref="GeneID:89797"
                     /db_xref="HGNC:HGNC:15997"
                     /db_xref="MIM:607026"
ORIGIN      
        1 mesvsessqq qkrkpvihgl edqkriytdw anhylaksgh krlikdlqqd vtdgvllaqi
       61 iqvvanekie dingcpknrs qmienidacl nflaakgini qglsaeeirn gnlkailglf
      121 fslsrykqqq qqpqkqhlss plppavsqva gapsqcqagt pqqqvpvtpq apcqphqpap
      181 hqqskaqaem qsrlpgptar vsaagseakt rggsttannr rsqsfnnydk skpvtspppp
      241 psshekepla ssasshpgms dnapaslesg ssstptncst ssaipqpgaa tkpwrsksls
      301 vkhsatvsml svkppgpeap rptpeamkpa pnnqksmlek lklfnskggs kagegpgsrd
      361 tscerletlp sfeeseelea asrmlttvgp assspkialk giaqrtfsra ltnkksslkg
      421 nekekekqqr ekdkekskdl akrasvterl dlkeepkedp sgaavpempk ksskiasfip
      481 kggklnsakk epmapshsgi pkpgmksmpg kspsapapsk egersrsgkl ssglpqqkpq
      541 ldgrhsssss slassegkgp ggttlnhsis sqtvsgsvgt tqttgsntvs vqlpqpqqqy
      601 nhpntatvap flyrsqtdte gnvtaessst gvsvepshft ktgqpaleel tgedpearrl
      661 rtvkniadlr qnleetmssl rgtqvthstl ettfdtnvtt emsgrsilsl tgrptplswr
      721 lgqssprlqa gdapsmgngy ppranasrfi ntesgryvys aplrrqlasr gssvchvdvs
      781 dkagdemdle gismdapgym sdgdvlskni rtdditsgym tdgglglytr rlnrlpdgma
      841 vvretlqrnt slglgdadsw ddsssvssgi sdtidnlstd dintsssiss yantpassrk
      901 nldvqtdaek hsqvernslw sgddvkksdg gsdsgikmep gskwrrnpsd vsdesdksts
      961 gkknpvisqt gswrrgmtaq vgitmprtka sapagalktp gtgktddakv sekgrlspka
     1021 sqvkrspsda grssgdeskk plpsssrtpt anansfgfkk qsgsaaglam itasgvtvts
     1081 rsatlgkipk ssalvsrsag rkssmdgaqn qddgylalss rtnlqyrslp rpsksnsrng
     1141 agnrsstssi dsnissksag lpvpklreps ktalgsslpg lvnqtdkekg issdnesvas
     1201 cnsvkvnpaa qpvsspaqts lqpgakypdv asptlrrlfg gkptkqvpia taenmknsvv
     1261 isnphatmtq qgnldspsgs gvlssgsssp lysknvdlnq splasspssa hsapsnsltw
     1321 gtnassssav skdglgfqsv sslhtscesi dislssggvp shnsstglia sskddsltpf
     1381 vrtnsvkttl sesdphldrn tlpkkglryt ptsqlrtqed akewlrshsa gglqdtaans
     1441 pfssgssvts psgtrfnfsq laspttvtqm slsnptmlrt hslsnadgqy dpytdsrfrn
     1501 ssmsldeksr tmsrsgsfrd gfeevhgssl slvsstssvy stpeekcqse irklrrelda
     1561 sqekvsaltt qltanahlva afeqslgnmt irlqsltmta eqkdselnel rktiellkkq
     1621 naaaqaaing vintpelnck gngtaqsadl rirrqhssds vssinsatsh ssvgsniesd
     1681 skkkkrknwl rssfkqafgk kkspksassh sdieemtdss lpsspklphn gstgstpllr
     1741 nshsnslise cmdseaetvm qlrnelrdke mkltdirlea lssahqldql reamnrmqse
     1801 ieklkaendr lksesqgsgc srapsqvsis asprqsmgls qhslnltest sldmllddtg
     1861 ecsarkeggr hvkivvsfqe emkwkedsrp hlfligcigv sgktkwdvld gvvrrlfkey
     1921 iihvdpvsql glnsdsvlgy sigeikrsnt setpellpcg ylvgenttis vtvkglaens
     1981 ldslvfesli pkpilqryvs lliehrriil sgpsgtgkty lanrlseyiv lregreltdg
     2041 viatfnvdhk sskelrqyls nladqcnsen navdmplvii ldnlhhvssl geifngllnc
     2101 kyhkcpyiig tmnqatsstp nlqlhhnfrw vlcanhtepv kgflgrflrr klmeteisgr
     2161 vrnmelvkii dwipkvwhhl nrfleahsss dvtigprlfl scpidvdgsr vwftdlwnys
     2221 iipylleair eglqlygrra pwedpakwvm dtypwaaspq qhewppllql rpedvgfdgy
     2281 smpregstsk qmppsdaegd plmnmlmrlq eaanysspqs ydsdsnsnsh hddildssle
     2341 stl
//
LOCUS       XP_054226379            2343 aa            linear   PRI 05-AUG-2025
DEFINITION  neuron navigator 2 isoform X33 [Homo sapiens].
ACCESSION   XP_054226379
VERSION     XP_054226379.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370404.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2343
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2343
                     /product="neuron navigator 2 isoform X33"
                     /calculated_mol_wt=252316
     Region          <1..52
                     /region_name="CH_SF"
                     /note="calponin homology (CH) domain superfamily; cl00030"
                     /db_xref="CDD:469584"
     Site            order(2..3,6..7,9,22..26,31,33..34,36..37,40..41,44)
                     /site_type="other"
                     /note="actin binding site [polypeptide binding]"
                     /db_xref="CDD:409031"
     Region          <164..593
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          821..>1122
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          <1542..>1814
                     /region_name="Mplasa_alph_rch"
                     /note="helix-rich Mycoplasma protein; TIGR04523"
                     /db_xref="CDD:275316"
     Region          1542..>1618
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          <1761..>1816
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          1846..2230
                     /region_name="McrB"
                     /note="5-methylcytosine-specific restriction endonuclease
                     McrBC, GTP-binding regulatory subunit McrB [Defense
                     mechanisms]; COG1401"
                     /db_xref="CDD:441011"
     CDS             1..2343
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /coded_by="XM_054370404.1:1794..8825"
                     /db_xref="GeneID:89797"
                     /db_xref="HGNC:HGNC:15997"
                     /db_xref="MIM:607026"
ORIGIN      
        1 mienidacln flaakginiq glsaeeirng nlkailglff slsrykqqqq qpqkqhlssp
       61 lppavsqvag apsqcqagtp qqqvpvtpqa pcqphqpaph qqskaqaemq ssasskdssq
      121 skiirftlgq kkisrlpgpt arvsaagsea ktrggsttan nrrsqsfnny dkskpvtspp
      181 pppsshekep lassasshpg msdnapasle sgssstptnc stssaipqpg aatkpwrsks
      241 lsvkhsatvs mlsvkppgpe aprptpeamk papnnqksml eklklfnskg gskagegpgs
      301 rdtscerlet lpsfeeseel eaasrmlttv gpassspkia lkgiaqrtfs raltnkkssl
      361 kgnekekekq qrekdkeksk dlakrasvte rldlkeepke dpsgaavpem pkksskiasf
      421 ipkggklnsa kkepmapshs gipkpgmksm pgkspsapap skegersrsg klssglpqqk
      481 pqldgrhsss ssslassegk gpggttlnhs issqtvsgsv gttqttgsnt vsvqlpqpqq
      541 qynhpntatv apflyrsqtd tegnvtaess stgvsvepsh ftktgqpale eltgedpear
      601 rlrtvkniad lrqnleetms slrgtqvths tlettfdtnv ttemsgrsil sltgrptpls
      661 wrlgqssprl qagdapsmgn gyppranasr fintesgryv ysaplrrqla srgssvchvd
      721 vsdkagdemd legismdapg ymsdgdvlsk nirtdditsg ymtdgglgly trrlnrlpdg
      781 mavvretlqr ntslglgdad swddsssvss gisdtidnls tddintsssi ssyantpass
      841 rknldvqtda ekhsqverns lwsgddvkks dggsdsgikm epgskwrrnp sdvsdesdks
      901 tsgkknpvis qtgswrrgmt aqvgitmprt kasapagalk tpgtgktdda kvsekgrlsp
      961 kasqvkrsps dagrssgdes kkplpsssrt ptanansfgf kkqsgsaagl amitasgvtv
     1021 tsrsatlgki pkssalvsrs agrkssmdga qnqddgylal ssrtnlqyrs lprpsksnsr
     1081 ngagnrssts sidsnissks aglpvpklre psktalgssl pglvnqtdke kgissdnesv
     1141 ascnsvkvnp aaqpvsspaq tslqpgakyp dvasptlrrl fggkptkqvp iataenmkns
     1201 vvisnphatm tqqgnldsps gsgvlssgss splysknvdl nqsplassps sahsapsnsl
     1261 twgtnassss avskdglgfq svsslhtsce sidislssgg vpshnsstgl iasskddslt
     1321 pfvrtnsvkt tlsesplssp aaspkfcrst lprkqdsdph ldrntlpkkg lrytptsqlr
     1381 tqedakewlr shsagglqdt aanspfssgs svtspsgtrf nfsqlasptt vtqmslsnpt
     1441 mlrthslsna dgqydpytds rfrnssmsld eksrtmsrsg sfrdgfeees wekssvdnfv
     1501 srlhsslhfs lplfhharye lvhgsslslv sstssvystp eekcqseirk lrreldasqe
     1561 kvsalttqlt anahlvaafe qslgnmtirl qsltmtaeqk dselnelrkt iellkkqnaa
     1621 aqaaingvin tpelnckgng taqsadlrir rqhssdsvss insatshssv gsniesdskk
     1681 kkrknwvnel rssfkqafgk kkspksassh sdieemtdss lpsspklphn gstgstpllr
     1741 nshsnslise cmdseaetvm qlrnelrdke mkltdirlea lssahqldql reamnrmqse
     1801 ieklkaendr lksesqgsgc srapsqvsis asprqsmgls qhslnltest sldmllddtg
     1861 ecsarkeggr hvkivvsfqe emkwkedsrp hlfligcigv sgktkwdvld gvvrrlfkey
     1921 iihvdpvsql glnsdsvlgy sigeikrsnt setpellpcg ylvgenttis vtvkglaens
     1981 ldslvfesli pkpilqryvs lliehrriil sgpsgtgkty lanrlseyiv lregreltdg
     2041 viatfnvdhk sskelrqyls nladqcnsen navdmplvii ldnlhhvssl geifngllnc
     2101 kyhkcpyiig tmnqatsstp nlqlhhnfrw vlcanhtepv kgflgrflrr klmeteisgr
     2161 vrnmelvkii dwipkvwhhl nrfleahsss dvtigprlfl scpidvdgsr vwftdlwnys
     2221 iipylleair eglqlygrra pwedpakwvm dtypwaaspq qhewppllql rpedvgfdgy
     2281 smpregstsk qmppsdaegd plmnmlmrlq eaanysspqs ydsdsnsnsh hddildssle
     2341 stl
//
LOCUS       XP_054226380            2343 aa            linear   PRI 05-AUG-2025
DEFINITION  neuron navigator 2 isoform X33 [Homo sapiens].
ACCESSION   XP_054226380
VERSION     XP_054226380.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370405.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2343
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2343
                     /product="neuron navigator 2 isoform X33"
                     /calculated_mol_wt=252316
     Region          <1..52
                     /region_name="CH_SF"
                     /note="calponin homology (CH) domain superfamily; cl00030"
                     /db_xref="CDD:469584"
     Site            order(2..3,6..7,9,22..26,31,33..34,36..37,40..41,44)
                     /site_type="other"
                     /note="actin binding site [polypeptide binding]"
                     /db_xref="CDD:409031"
     Region          <164..593
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          821..>1122
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          <1542..>1814
                     /region_name="Mplasa_alph_rch"
                     /note="helix-rich Mycoplasma protein; TIGR04523"
                     /db_xref="CDD:275316"
     Region          1542..>1618
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          <1761..>1816
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          1846..2230
                     /region_name="McrB"
                     /note="5-methylcytosine-specific restriction endonuclease
                     McrBC, GTP-binding regulatory subunit McrB [Defense
                     mechanisms]; COG1401"
                     /db_xref="CDD:441011"
     CDS             1..2343
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /coded_by="XM_054370405.1:262..7293"
                     /db_xref="GeneID:89797"
                     /db_xref="HGNC:HGNC:15997"
                     /db_xref="MIM:607026"
ORIGIN      
        1 mienidacln flaakginiq glsaeeirng nlkailglff slsrykqqqq qpqkqhlssp
       61 lppavsqvag apsqcqagtp qqqvpvtpqa pcqphqpaph qqskaqaemq ssasskdssq
      121 skiirftlgq kkisrlpgpt arvsaagsea ktrggsttan nrrsqsfnny dkskpvtspp
      181 pppsshekep lassasshpg msdnapasle sgssstptnc stssaipqpg aatkpwrsks
      241 lsvkhsatvs mlsvkppgpe aprptpeamk papnnqksml eklklfnskg gskagegpgs
      301 rdtscerlet lpsfeeseel eaasrmlttv gpassspkia lkgiaqrtfs raltnkkssl
      361 kgnekekekq qrekdkeksk dlakrasvte rldlkeepke dpsgaavpem pkksskiasf
      421 ipkggklnsa kkepmapshs gipkpgmksm pgkspsapap skegersrsg klssglpqqk
      481 pqldgrhsss ssslassegk gpggttlnhs issqtvsgsv gttqttgsnt vsvqlpqpqq
      541 qynhpntatv apflyrsqtd tegnvtaess stgvsvepsh ftktgqpale eltgedpear
      601 rlrtvkniad lrqnleetms slrgtqvths tlettfdtnv ttemsgrsil sltgrptpls
      661 wrlgqssprl qagdapsmgn gyppranasr fintesgryv ysaplrrqla srgssvchvd
      721 vsdkagdemd legismdapg ymsdgdvlsk nirtdditsg ymtdgglgly trrlnrlpdg
      781 mavvretlqr ntslglgdad swddsssvss gisdtidnls tddintsssi ssyantpass
      841 rknldvqtda ekhsqverns lwsgddvkks dggsdsgikm epgskwrrnp sdvsdesdks
      901 tsgkknpvis qtgswrrgmt aqvgitmprt kasapagalk tpgtgktdda kvsekgrlsp
      961 kasqvkrsps dagrssgdes kkplpsssrt ptanansfgf kkqsgsaagl amitasgvtv
     1021 tsrsatlgki pkssalvsrs agrkssmdga qnqddgylal ssrtnlqyrs lprpsksnsr
     1081 ngagnrssts sidsnissks aglpvpklre psktalgssl pglvnqtdke kgissdnesv
     1141 ascnsvkvnp aaqpvsspaq tslqpgakyp dvasptlrrl fggkptkqvp iataenmkns
     1201 vvisnphatm tqqgnldsps gsgvlssgss splysknvdl nqsplassps sahsapsnsl
     1261 twgtnassss avskdglgfq svsslhtsce sidislssgg vpshnsstgl iasskddslt
     1321 pfvrtnsvkt tlsesplssp aaspkfcrst lprkqdsdph ldrntlpkkg lrytptsqlr
     1381 tqedakewlr shsagglqdt aanspfssgs svtspsgtrf nfsqlasptt vtqmslsnpt
     1441 mlrthslsna dgqydpytds rfrnssmsld eksrtmsrsg sfrdgfeees wekssvdnfv
     1501 srlhsslhfs lplfhharye lvhgsslslv sstssvystp eekcqseirk lrreldasqe
     1561 kvsalttqlt anahlvaafe qslgnmtirl qsltmtaeqk dselnelrkt iellkkqnaa
     1621 aqaaingvin tpelnckgng taqsadlrir rqhssdsvss insatshssv gsniesdskk
     1681 kkrknwvnel rssfkqafgk kkspksassh sdieemtdss lpsspklphn gstgstpllr
     1741 nshsnslise cmdseaetvm qlrnelrdke mkltdirlea lssahqldql reamnrmqse
     1801 ieklkaendr lksesqgsgc srapsqvsis asprqsmgls qhslnltest sldmllddtg
     1861 ecsarkeggr hvkivvsfqe emkwkedsrp hlfligcigv sgktkwdvld gvvrrlfkey
     1921 iihvdpvsql glnsdsvlgy sigeikrsnt setpellpcg ylvgenttis vtvkglaens
     1981 ldslvfesli pkpilqryvs lliehrriil sgpsgtgkty lanrlseyiv lregreltdg
     2041 viatfnvdhk sskelrqyls nladqcnsen navdmplvii ldnlhhvssl geifngllnc
     2101 kyhkcpyiig tmnqatsstp nlqlhhnfrw vlcanhtepv kgflgrflrr klmeteisgr
     2161 vrnmelvkii dwipkvwhhl nrfleahsss dvtigprlfl scpidvdgsr vwftdlwnys
     2221 iipylleair eglqlygrra pwedpakwvm dtypwaaspq qhewppllql rpedvgfdgy
     2281 smpregstsk qmppsdaegd plmnmlmrlq eaanysspqs ydsdsnsnsh hddildssle
     2341 stl
//
LOCUS       XP_054226381            2335 aa            linear   PRI 05-AUG-2025
DEFINITION  neuron navigator 2 isoform X34 [Homo sapiens].
ACCESSION   XP_054226381
VERSION     XP_054226381.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370406.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2335
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2335
                     /product="neuron navigator 2 isoform X34"
                     /calculated_mol_wt=251696
     Region          5..118
                     /region_name="CH_NAV2"
                     /note="calponin homology (CH) domain found in neuron
                     navigator 2; cd21285"
                     /db_xref="CDD:409134"
     Site            order(15,19,73,75..76,79..80,82,91..99,104,106..107,
                     109..110,113..114,117)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409134"
     Region          <135..>322
                     /region_name="PRK07003"
                     /note="DNA polymerase III subunit gamma/tau"
                     /db_xref="CDD:235906"
     Region          <214..643
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          871..>1172
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          1537..>1613
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          <1753..>1808
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          1838..2222
                     /region_name="McrB"
                     /note="5-methylcytosine-specific restriction endonuclease
                     McrBC, GTP-binding regulatory subunit McrB [Defense
                     mechanisms]; COG1401"
                     /db_xref="CDD:441011"
     CDS             1..2335
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /coded_by="XM_054370406.1:300..7307"
                     /db_xref="GeneID:89797"
                     /db_xref="HGNC:HGNC:15997"
                     /db_xref="MIM:607026"
ORIGIN      
        1 msvmlwrweq nnttmkliyt dwanhylaks ghkrlikdlq qdvtdgvlla qiiqvvanek
       61 iedingcpkn rsqmienida clnflaakgi niqglsaeei rngnlkailg lffslsrykq
      121 qqqqpqkqhl ssplppavsq vagapsqcqa gtpqqqvpvt pqapcqphqp aphqqskaqa
      181 emqsrlpgpt arvsaagsea ktrggsttan nrrsqsfnny dkskpvtspp pppsshekep
      241 lassasshpg msdnapasle sgssstptnc stssaipqpg aatkpwrsks lsvkhsatvs
      301 mlsvkppgpe aprptpeamk papnnqksml eklklfnskg gskagegpgs rdtscerlet
      361 lpsfeeseel eaasrmlttv gpassspkia lkgiaqrtfs raltnkkssl kgnekekekq
      421 qrekdkeksk dlakrasvte rldlkeepke dpsgaavpem pkksskiasf ipkggklnsa
      481 kkepmapshs gipkpgmksm pgkspsapap skegersrsg klssglpqqk pqldgrhsss
      541 ssslassegk gpggttlnhs issqtvsgsv gttqttgsnt vsvqlpqpqq qynhpntatv
      601 apflyrsqtd tegnvtaess stgvsvepsh ftktgqpale eltgedpear rlrtvkniad
      661 lrqnleetms slrgtqvths tlettfdtnv ttemsgrsil sltgrptpls wrlgqssprl
      721 qagdapsmgn gyppranasr fintesgryv ysaplrrqla srgssvchvd vsdkagdemd
      781 legismdapg ymsdgdvlsk nirtdditsg ymtdgglgly trrlnrlpdg mavvretlqr
      841 ntslglgdad swddsssvss gisdtidnls tddintsssi ssyantpass rknldvqtda
      901 ekhsqverns lwsgddvkks dggsdsgikm epgskwrrnp sdvsdesdks tsgkknpvis
      961 qtgswrrgmt aqvgitmprt kasapagalk tpgtgktdda kvsekgrlsp kasqvkrsps
     1021 dagrssgdes kkplpsssrt ptanansfgf kkqsgsaagl amitasgvtv tsrsatlgki
     1081 pkssalvsrs agrkssmdga qnqddgylal ssrtnlqyrs lprpsksnsr ngagnrssts
     1141 sidsnissks aglpvpklre psktalgssl pglvnqtdke kgissdnesv ascnsvkvnp
     1201 aaqpvsspaq tslqpgakyp dvasptlrrl fggkptkqvp iataenmkns vvisnphatm
     1261 tqqgnldsps gsgvlssgss splysknvdl nqsplassps sahsapsnsl twgtnassss
     1321 avskdglgfq svsslhtsce sidislssgg vpshnsstgl iasskddslt pfvrtnsvkt
     1381 tlsesdphld rntlpkkglr ytptsqlrtq edakewlrsh sagglqdtaa nspfssgssv
     1441 tspsgtrfnf sqlaspttvt qmslsnptml rthslsnadg qydpytdsrf rnssmsldek
     1501 srtmsrsgsf rdgfeevhgs slslvsstss vystpeekcq seirklrrel dasqekvsal
     1561 ttqltanahl vaafeqslgn mtirlqsltm taeqkdseln elrktiellk kqnaaaqaai
     1621 ngvintpeln ckgngtaqsa dlrirrqhss dsvssinsat shssvgsnie sdskkkkrkn
     1681 wlrssfkqaf gkkkspksas shsdieemtd sslpsspklp hngstgstpl lrnshsnsli
     1741 secmdseaet vmqlrnelrd kemkltdirl ealssahqld qlreamnrmq seieklkaen
     1801 drlksesqgs gcsrapsqvs isasprqsmg lsqhslnlte stsldmlldd tgecsarkeg
     1861 grhvkivvsf qeemkwkeds rphlfligci gvsgktkwdv ldgvvrrlfk eyiihvdpvs
     1921 qlglnsdsvl gysigeikrs ntsetpellp cgylvgentt isvtvkglae nsldslvfes
     1981 lipkpilqry vslliehrri ilsgpsgtgk tylanrlsey ivlregrelt dgviatfnvd
     2041 hksskelrqy lsnladqcns ennavdmplv iildnlhhvs slgeifngll nckyhkcpyi
     2101 igtmnqatss tpnlqlhhnf rwvlcanhte pvkgflgrfl rrklmeteis grvrnmelvk
     2161 iidwipkvwh hlnrfleahs ssdvtigprl flscpidvdg srvwftdlwn ysiipyllea
     2221 ireglqlygr rapwedpakw vmdtypwaas pqqhewppll qlrpedvgfd gysmpregst
     2281 skqmppsdae gdplmnmlmr lqeaanyssp qsydsdsnsn shhddildss lestl
//
LOCUS       XP_054226382            2331 aa            linear   PRI 05-AUG-2025
DEFINITION  neuron navigator 2 isoform X35 [Homo sapiens].
ACCESSION   XP_054226382
VERSION     XP_054226382.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370407.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2331
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2331
                     /product="neuron navigator 2 isoform X35"
                     /calculated_mol_wt=251122
     Region          15..126
                     /region_name="CH_NAV2"
                     /note="calponin homology (CH) domain found in neuron
                     navigator 2; cd21285"
                     /db_xref="CDD:409134"
     Site            order(23,27,81,83..84,87..88,90,99..107,112,114..115,
                     117..118,121..122,125)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409134"
     Region          <143..>330
                     /region_name="PRK07003"
                     /note="DNA polymerase III subunit gamma/tau"
                     /db_xref="CDD:235906"
     Region          <222..651
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          879..>1180
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          <1530..>1802
                     /region_name="Mplasa_alph_rch"
                     /note="helix-rich Mycoplasma protein; TIGR04523"
                     /db_xref="CDD:275316"
     Region          1530..>1606
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          1741..>1799
                     /region_name="Atg16_CCD"
                     /note="Coiled-coiled domain of autophagy-related 16
                     (Atg16) family proteins; cl46300"
                     /db_xref="CDD:480640"
     Region          1834..2218
                     /region_name="McrB"
                     /note="5-methylcytosine-specific restriction endonuclease
                     McrBC, GTP-binding regulatory subunit McrB [Defense
                     mechanisms]; COG1401"
                     /db_xref="CDD:441011"
     CDS             1..2331
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /coded_by="XM_054370407.1:657..7652"
                     /db_xref="GeneID:89797"
                     /db_xref="HGNC:HGNC:15997"
                     /db_xref="MIM:607026"
ORIGIN      
        1 mesvsessqq qkrkpvihgl edqkriytdw anhylaksgh krlikdlqqd vtdgvllaqi
       61 iqvvanekie dingcpknrs qmienidacl nflaakgini qglsaeeirn gnlkailglf
      121 fslsrykqqq qqpqkqhlss plppavsqva gapsqcqagt pqqqvpvtpq apcqphqpap
      181 hqqskaqaem qsrlpgptar vsaagseakt rggsttannr rsqsfnnydk skpvtspppp
      241 psshekepla ssasshpgms dnapaslesg ssstptncst ssaipqpgaa tkpwrsksls
      301 vkhsatvsml svkppgpeap rptpeamkpa pnnqksmlek lklfnskggs kagegpgsrd
      361 tscerletlp sfeeseelea asrmlttvgp assspkialk giaqrtfsra ltnkksslkg
      421 nekekekqqr ekdkekskdl akrasvterl dlkeepkedp sgaavpempk ksskiasfip
      481 kggklnsakk epmapshsgi pkpgmksmpg kspsapapsk egersrsgkl ssglpqqkpq
      541 ldgrhsssss slassegkgp ggttlnhsis sqtvsgsvgt tqttgsntvs vqlpqpqqqy
      601 nhpntatvap flyrsqtdte gnvtaessst gvsvepshft ktgqpaleel tgedpearrl
      661 rtvkniadlr qnleetmssl rgtqvthstl ettfdtnvtt emsgrsilsl tgrptplswr
      721 lgqssprlqa gdapsmgngy ppranasrfi ntesgryvys aplrrqlasr gssvchvdvs
      781 dkagdemdle gismdapgym sdgdvlskni rtdditsgym tdgglglytr rlnrlpdgma
      841 vvretlqrnt slglgdadsw ddsssvssgi sdtidnlstd dintsssiss yantpassrk
      901 nldvqtdaek hsqvernslw sgddvkksdg gsdsgikmep gskwrrnpsd vsdesdksts
      961 gkknpvisqt gswrrgmtaq vgitmprtka sapagalktp gtgktddakv sekgrlspka
     1021 sqvkrspsda grssgdeskk plpsssrtpt anansfgfkk qsgsaaglam itasgvtvts
     1081 rsatlgkipk ssalvsrsag rkssmdgaqn qddgylalss rtnlqyrslp rpsksnsrng
     1141 agnrsstssi dsnissksag lpvpklreps ktalgsslpg lvnqtdkekg issdnesvas
     1201 cnsvkvnpaa qpvsspaqts lqpgakypdv asptlrrlfg gkptkqvpia taenmknsvv
     1261 isnphatmtq qgnldspsgs gvlssgsssp lysknvdlnq splasspssa hsapsnsltw
     1321 gtnassssav skdglgfqsv sslhtscesi dislssggvp shnsstglia sskddsltpf
     1381 vrtnsvkttl serytptsql rtqedakewl rshsagglqd taanspfssg ssvtspsgtr
     1441 fnfsqlaspt tvtqmslsnp tmlrthslsn adgqydpytd srfrnssmsl deksrtmsrs
     1501 gsfrdgfeev hgsslslvss tssvystpee kcqseirklr reldasqekv salttqltan
     1561 ahlvaafeqs lgnmtirlqs ltmtaeqkds elnelrktie llkkqnaaaq aaingvintp
     1621 elnckgngta qsadlrirrq hssdsvssin satshssvgs niesdskkkk rknwvnelrs
     1681 sfkqafgkkk spksasshsd ieemtdsslp sspklphngs tgstpllrns hsnslisecm
     1741 dseaetvmql rnelrdkemk ltdirleals sahqldqlre amnrmqseie klkaendrlk
     1801 sesqgsgcsr apsqvsisas prqsmglsqh slnltestsl dmllddtgec sarkeggrhv
     1861 kivvsfqeem kwkedsrphl fligcigvsg ktkwdvldgv vrrlfkeyii hvdpvsqlgl
     1921 nsdsvlgysi geikrsntse tpellpcgyl vgenttisvt vkglaensld slvfeslipk
     1981 pilqryvsll iehrriilsg psgtgktyla nrlseyivlr egreltdgvi atfnvdhkss
     2041 kelrqylsnl adqcnsenna vdmplviild nlhhvsslge ifngllncky hkcpyiigtm
     2101 nqatsstpnl qlhhnfrwvl canhtepvkg flgrflrrkl meteisgrvr nmelvkiidw
     2161 ipkvwhhlnr fleahsssdv tigprlflsc pidvdgsrvw ftdlwnysii pylleaireg
     2221 lqlygrrapw edpakwvmdt ypwaaspqqh ewppllqlrp edvgfdgysm pregstskqm
     2281 ppsdaegdpl mnmlmrlqea anysspqsyd sdsnsnshhd dildsslest l
//
LOCUS       XP_054226383            2328 aa            linear   PRI 05-AUG-2025
DEFINITION  neuron navigator 2 isoform X36 [Homo sapiens].
ACCESSION   XP_054226383
VERSION     XP_054226383.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370408.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2328
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2328
                     /product="neuron navigator 2 isoform X36"
                     /calculated_mol_wt=250780
     Region          15..126
                     /region_name="CH_NAV2"
                     /note="calponin homology (CH) domain found in neuron
                     navigator 2; cd21285"
                     /db_xref="CDD:409134"
     Site            order(23,27,81,83..84,87..88,90,99..107,112,114..115,
                     117..118,121..122,125)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409134"
     Region          <143..>330
                     /region_name="PRK07003"
                     /note="DNA polymerase III subunit gamma/tau"
                     /db_xref="CDD:235906"
     Region          <222..651
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          879..>1180
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          1530..>1606
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          1738..>1796
                     /region_name="Atg16_CCD"
                     /note="Coiled-coiled domain of autophagy-related 16
                     (Atg16) family proteins; cl46300"
                     /db_xref="CDD:480640"
     Region          1831..2215
                     /region_name="McrB"
                     /note="5-methylcytosine-specific restriction endonuclease
                     McrBC, GTP-binding regulatory subunit McrB [Defense
                     mechanisms]; COG1401"
                     /db_xref="CDD:441011"
     CDS             1..2328
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /coded_by="XM_054370408.1:657..7643"
                     /db_xref="GeneID:89797"
                     /db_xref="HGNC:HGNC:15997"
                     /db_xref="MIM:607026"
ORIGIN      
        1 mesvsessqq qkrkpvihgl edqkriytdw anhylaksgh krlikdlqqd vtdgvllaqi
       61 iqvvanekie dingcpknrs qmienidacl nflaakgini qglsaeeirn gnlkailglf
      121 fslsrykqqq qqpqkqhlss plppavsqva gapsqcqagt pqqqvpvtpq apcqphqpap
      181 hqqskaqaem qsrlpgptar vsaagseakt rggsttannr rsqsfnnydk skpvtspppp
      241 psshekepla ssasshpgms dnapaslesg ssstptncst ssaipqpgaa tkpwrsksls
      301 vkhsatvsml svkppgpeap rptpeamkpa pnnqksmlek lklfnskggs kagegpgsrd
      361 tscerletlp sfeeseelea asrmlttvgp assspkialk giaqrtfsra ltnkksslkg
      421 nekekekqqr ekdkekskdl akrasvterl dlkeepkedp sgaavpempk ksskiasfip
      481 kggklnsakk epmapshsgi pkpgmksmpg kspsapapsk egersrsgkl ssglpqqkpq
      541 ldgrhsssss slassegkgp ggttlnhsis sqtvsgsvgt tqttgsntvs vqlpqpqqqy
      601 nhpntatvap flyrsqtdte gnvtaessst gvsvepshft ktgqpaleel tgedpearrl
      661 rtvkniadlr qnleetmssl rgtqvthstl ettfdtnvtt emsgrsilsl tgrptplswr
      721 lgqssprlqa gdapsmgngy ppranasrfi ntesgryvys aplrrqlasr gssvchvdvs
      781 dkagdemdle gismdapgym sdgdvlskni rtdditsgym tdgglglytr rlnrlpdgma
      841 vvretlqrnt slglgdadsw ddsssvssgi sdtidnlstd dintsssiss yantpassrk
      901 nldvqtdaek hsqvernslw sgddvkksdg gsdsgikmep gskwrrnpsd vsdesdksts
      961 gkknpvisqt gswrrgmtaq vgitmprtka sapagalktp gtgktddakv sekgrlspka
     1021 sqvkrspsda grssgdeskk plpsssrtpt anansfgfkk qsgsaaglam itasgvtvts
     1081 rsatlgkipk ssalvsrsag rkssmdgaqn qddgylalss rtnlqyrslp rpsksnsrng
     1141 agnrsstssi dsnissksag lpvpklreps ktalgsslpg lvnqtdkekg issdnesvas
     1201 cnsvkvnpaa qpvsspaqts lqpgakypdv asptlrrlfg gkptkqvpia taenmknsvv
     1261 isnphatmtq qgnldspsgs gvlssgsssp lysknvdlnq splasspssa hsapsnsltw
     1321 gtnassssav skdglgfqsv sslhtscesi dislssggvp shnsstglia sskddsltpf
     1381 vrtnsvkttl serytptsql rtqedakewl rshsagglqd taanspfssg ssvtspsgtr
     1441 fnfsqlaspt tvtqmslsnp tmlrthslsn adgqydpytd srfrnssmsl deksrtmsrs
     1501 gsfrdgfeev hgsslslvss tssvystpee kcqseirklr reldasqekv salttqltan
     1561 ahlvaafeqs lgnmtirlqs ltmtaeqkds elnelrktie llkkqnaaaq aaingvintp
     1621 elnckgngta qsadlrirrq hssdsvssin satshssvgs niesdskkkk rknwlrssfk
     1681 qafgkkkspk sasshsdiee mtdsslpssp klphngstgs tpllrnshsn slisecmdse
     1741 aetvmqlrne lrdkemkltd irlealssah qldqlreamn rmqseieklk aendrlkses
     1801 qgsgcsraps qvsisasprq smglsqhsln ltestsldml lddtgecsar keggrhvkiv
     1861 vsfqeemkwk edsrphlfli gcigvsgktk wdvldgvvrr lfkeyiihvd pvsqlglnsd
     1921 svlgysigei krsntsetpe llpcgylvge nttisvtvkg laensldslv feslipkpil
     1981 qryvsllieh rriilsgpsg tgktylanrl seyivlregr eltdgviatf nvdhksskel
     2041 rqylsnladq cnsennavdm plviildnlh hvsslgeifn gllnckyhkc pyiigtmnqa
     2101 tsstpnlqlh hnfrwvlcan htepvkgflg rflrrklmet eisgrvrnme lvkiidwipk
     2161 vwhhlnrfle ahsssdvtig prlflscpid vdgsrvwftd lwnysiipyl leaireglql
     2221 ygrrapwedp akwvmdtypw aaspqqhewp pllqlrpedv gfdgysmpre gstskqmpps
     2281 daegdplmnm lmrlqeaany sspqsydsds nsnshhddil dsslestl
//
LOCUS       XP_054226384            2328 aa            linear   PRI 05-AUG-2025
DEFINITION  neuron navigator 2 isoform X36 [Homo sapiens].
ACCESSION   XP_054226384
VERSION     XP_054226384.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370409.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2328
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2328
                     /product="neuron navigator 2 isoform X36"
                     /calculated_mol_wt=250780
     Region          15..126
                     /region_name="CH_NAV2"
                     /note="calponin homology (CH) domain found in neuron
                     navigator 2; cd21285"
                     /db_xref="CDD:409134"
     Site            order(23,27,81,83..84,87..88,90,99..107,112,114..115,
                     117..118,121..122,125)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409134"
     Region          <143..>330
                     /region_name="PRK07003"
                     /note="DNA polymerase III subunit gamma/tau"
                     /db_xref="CDD:235906"
     Region          <222..651
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          879..>1180
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          1530..>1606
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          1738..>1796
                     /region_name="Atg16_CCD"
                     /note="Coiled-coiled domain of autophagy-related 16
                     (Atg16) family proteins; cl46300"
                     /db_xref="CDD:480640"
     Region          1831..2215
                     /region_name="McrB"
                     /note="5-methylcytosine-specific restriction endonuclease
                     McrBC, GTP-binding regulatory subunit McrB [Defense
                     mechanisms]; COG1401"
                     /db_xref="CDD:441011"
     CDS             1..2328
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /coded_by="XM_054370409.1:771..7757"
                     /db_xref="GeneID:89797"
                     /db_xref="HGNC:HGNC:15997"
                     /db_xref="MIM:607026"
ORIGIN      
        1 mesvsessqq qkrkpvihgl edqkriytdw anhylaksgh krlikdlqqd vtdgvllaqi
       61 iqvvanekie dingcpknrs qmienidacl nflaakgini qglsaeeirn gnlkailglf
      121 fslsrykqqq qqpqkqhlss plppavsqva gapsqcqagt pqqqvpvtpq apcqphqpap
      181 hqqskaqaem qsrlpgptar vsaagseakt rggsttannr rsqsfnnydk skpvtspppp
      241 psshekepla ssasshpgms dnapaslesg ssstptncst ssaipqpgaa tkpwrsksls
      301 vkhsatvsml svkppgpeap rptpeamkpa pnnqksmlek lklfnskggs kagegpgsrd
      361 tscerletlp sfeeseelea asrmlttvgp assspkialk giaqrtfsra ltnkksslkg
      421 nekekekqqr ekdkekskdl akrasvterl dlkeepkedp sgaavpempk ksskiasfip
      481 kggklnsakk epmapshsgi pkpgmksmpg kspsapapsk egersrsgkl ssglpqqkpq
      541 ldgrhsssss slassegkgp ggttlnhsis sqtvsgsvgt tqttgsntvs vqlpqpqqqy
      601 nhpntatvap flyrsqtdte gnvtaessst gvsvepshft ktgqpaleel tgedpearrl
      661 rtvkniadlr qnleetmssl rgtqvthstl ettfdtnvtt emsgrsilsl tgrptplswr
      721 lgqssprlqa gdapsmgngy ppranasrfi ntesgryvys aplrrqlasr gssvchvdvs
      781 dkagdemdle gismdapgym sdgdvlskni rtdditsgym tdgglglytr rlnrlpdgma
      841 vvretlqrnt slglgdadsw ddsssvssgi sdtidnlstd dintsssiss yantpassrk
      901 nldvqtdaek hsqvernslw sgddvkksdg gsdsgikmep gskwrrnpsd vsdesdksts
      961 gkknpvisqt gswrrgmtaq vgitmprtka sapagalktp gtgktddakv sekgrlspka
     1021 sqvkrspsda grssgdeskk plpsssrtpt anansfgfkk qsgsaaglam itasgvtvts
     1081 rsatlgkipk ssalvsrsag rkssmdgaqn qddgylalss rtnlqyrslp rpsksnsrng
     1141 agnrsstssi dsnissksag lpvpklreps ktalgsslpg lvnqtdkekg issdnesvas
     1201 cnsvkvnpaa qpvsspaqts lqpgakypdv asptlrrlfg gkptkqvpia taenmknsvv
     1261 isnphatmtq qgnldspsgs gvlssgsssp lysknvdlnq splasspssa hsapsnsltw
     1321 gtnassssav skdglgfqsv sslhtscesi dislssggvp shnsstglia sskddsltpf
     1381 vrtnsvkttl serytptsql rtqedakewl rshsagglqd taanspfssg ssvtspsgtr
     1441 fnfsqlaspt tvtqmslsnp tmlrthslsn adgqydpytd srfrnssmsl deksrtmsrs
     1501 gsfrdgfeev hgsslslvss tssvystpee kcqseirklr reldasqekv salttqltan
     1561 ahlvaafeqs lgnmtirlqs ltmtaeqkds elnelrktie llkkqnaaaq aaingvintp
     1621 elnckgngta qsadlrirrq hssdsvssin satshssvgs niesdskkkk rknwlrssfk
     1681 qafgkkkspk sasshsdiee mtdsslpssp klphngstgs tpllrnshsn slisecmdse
     1741 aetvmqlrne lrdkemkltd irlealssah qldqlreamn rmqseieklk aendrlkses
     1801 qgsgcsraps qvsisasprq smglsqhsln ltestsldml lddtgecsar keggrhvkiv
     1861 vsfqeemkwk edsrphlfli gcigvsgktk wdvldgvvrr lfkeyiihvd pvsqlglnsd
     1921 svlgysigei krsntsetpe llpcgylvge nttisvtvkg laensldslv feslipkpil
     1981 qryvsllieh rriilsgpsg tgktylanrl seyivlregr eltdgviatf nvdhksskel
     2041 rqylsnladq cnsennavdm plviildnlh hvsslgeifn gllnckyhkc pyiigtmnqa
     2101 tsstpnlqlh hnfrwvlcan htepvkgflg rflrrklmet eisgrvrnme lvkiidwipk
     2161 vwhhlnrfle ahsssdvtig prlflscpid vdgsrvwftd lwnysiipyl leaireglql
     2221 ygrrapwedp akwvmdtypw aaspqqhewp pllqlrpedv gfdgysmpre gstskqmpps
     2281 daegdplmnm lmrlqeaany sspqsydsds nsnshhddil dsslestl
//
LOCUS       XP_054226385            2323 aa            linear   PRI 05-AUG-2025
DEFINITION  neuron navigator 2 isoform X37 [Homo sapiens].
ACCESSION   XP_054226385
VERSION     XP_054226385.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370410.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2323
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2323
                     /product="neuron navigator 2 isoform X37"
                     /calculated_mol_wt=250365
     Region          5..118
                     /region_name="CH_NAV2"
                     /note="calponin homology (CH) domain found in neuron
                     navigator 2; cd21285"
                     /db_xref="CDD:409134"
     Site            order(15,19,73,75..76,79..80,82,91..99,104,106..107,
                     109..110,113..114,117)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409134"
     Region          <135..>322
                     /region_name="PRK07003"
                     /note="DNA polymerase III subunit gamma/tau"
                     /db_xref="CDD:235906"
     Region          <214..643
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          871..>1172
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          <1522..>1794
                     /region_name="Mplasa_alph_rch"
                     /note="helix-rich Mycoplasma protein; TIGR04523"
                     /db_xref="CDD:275316"
     Region          1522..>1598
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          <1741..>1796
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          1826..2210
                     /region_name="McrB"
                     /note="5-methylcytosine-specific restriction endonuclease
                     McrBC, GTP-binding regulatory subunit McrB [Defense
                     mechanisms]; COG1401"
                     /db_xref="CDD:441011"
     CDS             1..2323
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /coded_by="XM_054370410.1:300..7271"
                     /db_xref="GeneID:89797"
                     /db_xref="HGNC:HGNC:15997"
                     /db_xref="MIM:607026"
ORIGIN      
        1 msvmlwrweq nnttmkliyt dwanhylaks ghkrlikdlq qdvtdgvlla qiiqvvanek
       61 iedingcpkn rsqmienida clnflaakgi niqglsaeei rngnlkailg lffslsrykq
      121 qqqqpqkqhl ssplppavsq vagapsqcqa gtpqqqvpvt pqapcqphqp aphqqskaqa
      181 emqsrlpgpt arvsaagsea ktrggsttan nrrsqsfnny dkskpvtspp pppsshekep
      241 lassasshpg msdnapasle sgssstptnc stssaipqpg aatkpwrsks lsvkhsatvs
      301 mlsvkppgpe aprptpeamk papnnqksml eklklfnskg gskagegpgs rdtscerlet
      361 lpsfeeseel eaasrmlttv gpassspkia lkgiaqrtfs raltnkkssl kgnekekekq
      421 qrekdkeksk dlakrasvte rldlkeepke dpsgaavpem pkksskiasf ipkggklnsa
      481 kkepmapshs gipkpgmksm pgkspsapap skegersrsg klssglpqqk pqldgrhsss
      541 ssslassegk gpggttlnhs issqtvsgsv gttqttgsnt vsvqlpqpqq qynhpntatv
      601 apflyrsqtd tegnvtaess stgvsvepsh ftktgqpale eltgedpear rlrtvkniad
      661 lrqnleetms slrgtqvths tlettfdtnv ttemsgrsil sltgrptpls wrlgqssprl
      721 qagdapsmgn gyppranasr fintesgryv ysaplrrqla srgssvchvd vsdkagdemd
      781 legismdapg ymsdgdvlsk nirtdditsg ymtdgglgly trrlnrlpdg mavvretlqr
      841 ntslglgdad swddsssvss gisdtidnls tddintsssi ssyantpass rknldvqtda
      901 ekhsqverns lwsgddvkks dggsdsgikm epgskwrrnp sdvsdesdks tsgkknpvis
      961 qtgswrrgmt aqvgitmprt kasapagalk tpgtgktdda kvsekgrlsp kasqvkrsps
     1021 dagrssgdes kkplpsssrt ptanansfgf kkqsgsaagl amitasgvtv tsrsatlgki
     1081 pkssalvsrs agrkssmdga qnqddgylal ssrtnlqyrs lprpsksnsr ngagnrssts
     1141 sidsnissks aglpvpklre psktalgssl pglvnqtdke kgissdnesv ascnsvkvnp
     1201 aaqpvsspaq tslqpgakyp dvasptlrrl fggkptkqvp iataenmkns vvisnphatm
     1261 tqqgnldsps gsgvlssgss splysknvdl nqsplassps sahsapsnsl twgtnassss
     1321 avskdglgfq svsslhtsce sidislssgg vpshnsstgl iasskddslt pfvrtnsvkt
     1381 tlserytpts qlrtqedake wlrshsaggl qdtaanspfs sgssvtspsg trfnfsqlas
     1441 pttvtqmsls nptmlrthsl snadgqydpy tdsrfrnssm sldeksrtms rsgsfrdgfe
     1501 evhgsslslv sstssvystp eekcqseirk lrreldasqe kvsalttqlt anahlvaafe
     1561 qslgnmtirl qsltmtaeqk dselnelrkt iellkkqnaa aqaaingvin tpelnckgng
     1621 taqsadlrir rqhssdsvss insatshssv gsniesdskk kkrknwvnel rssfkqafgk
     1681 kkspksassh sdieemtdss lpsspklphn gstgstpllr nshsnslise cmdseaetvm
     1741 qlrnelrdke mkltdirlea lssahqldql reamnrmqse ieklkaendr lksesqgsgc
     1801 srapsqvsis asprqsmgls qhslnltest sldmllddtg ecsarkeggr hvkivvsfqe
     1861 emkwkedsrp hlfligcigv sgktkwdvld gvvrrlfkey iihvdpvsql glnsdsvlgy
     1921 sigeikrsnt setpellpcg ylvgenttis vtvkglaens ldslvfesli pkpilqryvs
     1981 lliehrriil sgpsgtgkty lanrlseyiv lregreltdg viatfnvdhk sskelrqyls
     2041 nladqcnsen navdmplvii ldnlhhvssl geifngllnc kyhkcpyiig tmnqatsstp
     2101 nlqlhhnfrw vlcanhtepv kgflgrflrr klmeteisgr vrnmelvkii dwipkvwhhl
     2161 nrfleahsss dvtigprlfl scpidvdgsr vwftdlwnys iipylleair eglqlygrra
     2221 pwedpakwvm dtypwaaspq qhewppllql rpedvgfdgy smpregstsk qmppsdaegd
     2281 plmnmlmrlq eaanysspqs ydsdsnsnsh hddildssle stl
//
LOCUS       XP_054226386            2320 aa            linear   PRI 05-AUG-2025
DEFINITION  neuron navigator 2 isoform X38 [Homo sapiens].
ACCESSION   XP_054226386
VERSION     XP_054226386.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370411.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2320
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2320
                     /product="neuron navigator 2 isoform X38"
                     /calculated_mol_wt=250023
     Region          5..118
                     /region_name="CH_NAV2"
                     /note="calponin homology (CH) domain found in neuron
                     navigator 2; cd21285"
                     /db_xref="CDD:409134"
     Site            order(15,19,73,75..76,79..80,82,91..99,104,106..107,
                     109..110,113..114,117)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409134"
     Region          <135..>322
                     /region_name="PRK07003"
                     /note="DNA polymerase III subunit gamma/tau"
                     /db_xref="CDD:235906"
     Region          <214..643
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          871..>1172
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          1522..>1598
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          <1738..>1793
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          1823..2207
                     /region_name="McrB"
                     /note="5-methylcytosine-specific restriction endonuclease
                     McrBC, GTP-binding regulatory subunit McrB [Defense
                     mechanisms]; COG1401"
                     /db_xref="CDD:441011"
     CDS             1..2320
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /coded_by="XM_054370411.1:300..7262"
                     /db_xref="GeneID:89797"
                     /db_xref="HGNC:HGNC:15997"
                     /db_xref="MIM:607026"
ORIGIN      
        1 msvmlwrweq nnttmkliyt dwanhylaks ghkrlikdlq qdvtdgvlla qiiqvvanek
       61 iedingcpkn rsqmienida clnflaakgi niqglsaeei rngnlkailg lffslsrykq
      121 qqqqpqkqhl ssplppavsq vagapsqcqa gtpqqqvpvt pqapcqphqp aphqqskaqa
      181 emqsrlpgpt arvsaagsea ktrggsttan nrrsqsfnny dkskpvtspp pppsshekep
      241 lassasshpg msdnapasle sgssstptnc stssaipqpg aatkpwrsks lsvkhsatvs
      301 mlsvkppgpe aprptpeamk papnnqksml eklklfnskg gskagegpgs rdtscerlet
      361 lpsfeeseel eaasrmlttv gpassspkia lkgiaqrtfs raltnkkssl kgnekekekq
      421 qrekdkeksk dlakrasvte rldlkeepke dpsgaavpem pkksskiasf ipkggklnsa
      481 kkepmapshs gipkpgmksm pgkspsapap skegersrsg klssglpqqk pqldgrhsss
      541 ssslassegk gpggttlnhs issqtvsgsv gttqttgsnt vsvqlpqpqq qynhpntatv
      601 apflyrsqtd tegnvtaess stgvsvepsh ftktgqpale eltgedpear rlrtvkniad
      661 lrqnleetms slrgtqvths tlettfdtnv ttemsgrsil sltgrptpls wrlgqssprl
      721 qagdapsmgn gyppranasr fintesgryv ysaplrrqla srgssvchvd vsdkagdemd
      781 legismdapg ymsdgdvlsk nirtdditsg ymtdgglgly trrlnrlpdg mavvretlqr
      841 ntslglgdad swddsssvss gisdtidnls tddintsssi ssyantpass rknldvqtda
      901 ekhsqverns lwsgddvkks dggsdsgikm epgskwrrnp sdvsdesdks tsgkknpvis
      961 qtgswrrgmt aqvgitmprt kasapagalk tpgtgktdda kvsekgrlsp kasqvkrsps
     1021 dagrssgdes kkplpsssrt ptanansfgf kkqsgsaagl amitasgvtv tsrsatlgki
     1081 pkssalvsrs agrkssmdga qnqddgylal ssrtnlqyrs lprpsksnsr ngagnrssts
     1141 sidsnissks aglpvpklre psktalgssl pglvnqtdke kgissdnesv ascnsvkvnp
     1201 aaqpvsspaq tslqpgakyp dvasptlrrl fggkptkqvp iataenmkns vvisnphatm
     1261 tqqgnldsps gsgvlssgss splysknvdl nqsplassps sahsapsnsl twgtnassss
     1321 avskdglgfq svsslhtsce sidislssgg vpshnsstgl iasskddslt pfvrtnsvkt
     1381 tlserytpts qlrtqedake wlrshsaggl qdtaanspfs sgssvtspsg trfnfsqlas
     1441 pttvtqmsls nptmlrthsl snadgqydpy tdsrfrnssm sldeksrtms rsgsfrdgfe
     1501 evhgsslslv sstssvystp eekcqseirk lrreldasqe kvsalttqlt anahlvaafe
     1561 qslgnmtirl qsltmtaeqk dselnelrkt iellkkqnaa aqaaingvin tpelnckgng
     1621 taqsadlrir rqhssdsvss insatshssv gsniesdskk kkrknwlrss fkqafgkkks
     1681 pksasshsdi eemtdsslps spklphngst gstpllrnsh snslisecmd seaetvmqlr
     1741 nelrdkemkl tdirlealss ahqldqlrea mnrmqseiek lkaendrlks esqgsgcsra
     1801 psqvsisasp rqsmglsqhs lnltestsld mllddtgecs arkeggrhvk ivvsfqeemk
     1861 wkedsrphlf ligcigvsgk tkwdvldgvv rrlfkeyiih vdpvsqlgln sdsvlgysig
     1921 eikrsntset pellpcgylv genttisvtv kglaenslds lvfeslipkp ilqryvslli
     1981 ehrriilsgp sgtgktylan rlseyivlre greltdgvia tfnvdhkssk elrqylsnla
     2041 dqcnsennav dmplviildn lhhvsslgei fngllnckyh kcpyiigtmn qatsstpnlq
     2101 lhhnfrwvlc anhtepvkgf lgrflrrklm eteisgrvrn melvkiidwi pkvwhhlnrf
     2161 leahsssdvt igprlflscp idvdgsrvwf tdlwnysiip ylleairegl qlygrrapwe
     2221 dpakwvmdty pwaaspqqhe wppllqlrpe dvgfdgysmp regstskqmp psdaegdplm
     2281 nmlmrlqeaa nysspqsyds dsnsnshhdd ildsslestl
//
LOCUS       XP_054226387            2320 aa            linear   PRI 05-AUG-2025
DEFINITION  neuron navigator 2 isoform X39 [Homo sapiens].
ACCESSION   XP_054226387
VERSION     XP_054226387.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370412.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2320
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2320
                     /product="neuron navigator 2 isoform X39"
                     /calculated_mol_wt=249837
     Region          <1..52
                     /region_name="CH_SF"
                     /note="calponin homology (CH) domain superfamily; cl00030"
                     /db_xref="CDD:469584"
     Site            order(2..3,6..7,9,22..26,31,33..34,36..37,40..41,44)
                     /site_type="other"
                     /note="actin binding site [polypeptide binding]"
                     /db_xref="CDD:409031"
     Region          <62..>249
                     /region_name="PRK07003"
                     /note="DNA polymerase III subunit gamma/tau"
                     /db_xref="CDD:235906"
     Region          <141..570
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          <1519..>1791
                     /region_name="Mplasa_alph_rch"
                     /note="helix-rich Mycoplasma protein; TIGR04523"
                     /db_xref="CDD:275316"
     Region          1519..>1595
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          <1738..>1793
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          1823..2207
                     /region_name="McrB"
                     /note="5-methylcytosine-specific restriction endonuclease
                     McrBC, GTP-binding regulatory subunit McrB [Defense
                     mechanisms]; COG1401"
                     /db_xref="CDD:441011"
     CDS             1..2320
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /coded_by="XM_054370412.1:1793..8755"
                     /db_xref="GeneID:89797"
                     /db_xref="HGNC:HGNC:15997"
                     /db_xref="MIM:607026"
ORIGIN      
        1 mienidacln flaakginiq glsaeeirng nlkailglff slsrykqqqq qpqkqhlssp
       61 lppavsqvag apsqcqagtp qqqvpvtpqa pcqphqpaph qqskaqaemq srlpgptarv
      121 saagseaktr ggsttannrr sqsfnnydks kpvtsppppp sshekeplas sasshpgmsd
      181 napaslesgs sstptncsts saipqpgaat kpwrskslsv khsatvsmls vkppgpeapr
      241 ptpeamkpap nnqksmlekl klfnskggsk agegpgsrdt scerletlps feeseeleaa
      301 srmlttvgpa ssspkialkg iaqrtfsral tnkksslkgn ekekekqqre kdkekskdla
      361 krasvterld lkeepkedps gaavpempkk sskiasfipk ggklnsakke pmapshsgip
      421 kpgmksmpgk spsapapske gersrsgkls sglpqqkpql dgrhssssss lassegkgpg
      481 gttlnhsiss qtvsgsvgtt qttgsntvsv qlpqpqqqyn hpntatvapf lyrsqtdteg
      541 nvtaessstg vsvepshftk tgqpaleelt gedpearrlr tvkniadlrq nleetmsslr
      601 gtqvthstle ttfdtnvtte msgrsilslt grptplswrl gqssprlqag dapsmgngyp
      661 pranasrfin tesgryvysa plrrqlasrg ssvchvdvsd kagdemdleg ismdapgyms
      721 dgdvlsknir tdditsgymt dgglglytrr lnrlpdgmav vretlqrnts lglgdadswd
      781 dsssvssgis dtidnlstdd intsssissy antpassrkn ldvqtdaekh sqvernslws
      841 gddvkksdgg sdsgikmepg skwrrnpsdv sdesdkstsg kknpvisqtg swrrgmtaqv
      901 gitmprtkas apagalktpg tgktddakvs ekgrlspkas qvkrspsdag rssgdeskkp
      961 lpsssrtpta nansfgfkkq sgsaaglami tasgvtvtsr satlgkipks salvsrsagr
     1021 kssmdgaqnq ddgylalssr tnlqyrslpr psksnsrnga gnrsstssid snissksagl
     1081 pvpklrepsk talgsslpgl vnqtdkekgi ssdnesvasc nsvkvnpaaq pvsspaqtsl
     1141 qpgakypdva sptlrrlfgg kptkqvpiat aenmknsvvi snphatmtqq gnldspsgsg
     1201 vlssgssspl ysknvdlnqs plasspssah sapsnsltwg tnassssavs kdglgfqsvs
     1261 slhtscesid islssggvps hnsstglias skddsltpfv rtnsvkttls esplsspaas
     1321 pkfcrstlpr kqdsdphldr ntlpkkglry tptsqlrtqe dakewlrshs agglqdtaan
     1381 spfssgssvt spsgtrfnfs qlaspttvtq mslsnptmlr thslsnadgq ydpytdsrfr
     1441 nssmsldeks rtmsrsgsfr dgfeeeswek ssvdnfvsrl hsslhfslpl fhharyelvh
     1501 gsslslvsst ssvystpeek cqseirklrr eldasqekvs alttqltana hlvaafeqsl
     1561 gnmtirlqsl tmtaeqkdse lnelrktiel lkkqnaaaqa aingvintpe lnckgngtaq
     1621 sadlrirrqh ssdsvssins atshssvgsn iesdskkkkr knwvnelrss fkqafgkkks
     1681 pksasshsdi eemtdsslps spklphngst gstpllrnsh snslisecmd seaetvmqlr
     1741 nelrdkemkl tdirlealss ahqldqlrea mnrmqseiek lkaendrlks esqgsgcsra
     1801 psqvsisasp rqsmglsqhs lnltestsld mllddtgecs arkeggrhvk ivvsfqeemk
     1861 wkedsrphlf ligcigvsgk tkwdvldgvv rrlfkeyiih vdpvsqlgln sdsvlgysig
     1921 eikrsntset pellpcgylv genttisvtv kglaenslds lvfeslipkp ilqryvslli
     1981 ehrriilsgp sgtgktylan rlseyivlre greltdgvia tfnvdhkssk elrqylsnla
     2041 dqcnsennav dmplviildn lhhvsslgei fngllnckyh kcpyiigtmn qatsstpnlq
     2101 lhhnfrwvlc anhtepvkgf lgrflrrklm eteisgrvrn melvkiidwi pkvwhhlnrf
     2161 leahsssdvt igprlflscp idvdgsrvwf tdlwnysiip ylleairegl qlygrrapwe
     2221 dpakwvmdty pwaaspqqhe wppllqlrpe dvgfdgysmp regstskqmp psdaegdplm
     2281 nmlmrlqeaa nysspqsyds dsnsnshhdd ildsslestl
//
LOCUS       XP_054226388            1515 aa            linear   PRI 05-AUG-2025
DEFINITION  neuron navigator 2 isoform X40 [Homo sapiens].
ACCESSION   XP_054226388
VERSION     XP_054226388.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370413.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1515
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1515
                     /product="neuron navigator 2 isoform X40"
                     /calculated_mol_wt=164160
     Region          87..>373
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          717..>793
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          <933..>988
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          1018..1402
                     /region_name="McrB"
                     /note="5-methylcytosine-specific restriction endonuclease
                     McrBC, GTP-binding regulatory subunit McrB [Defense
                     mechanisms]; COG1401"
                     /db_xref="CDD:441011"
     CDS             1..1515
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /coded_by="XM_054370413.1:18..4565"
                     /db_xref="GeneID:89797"
                     /db_xref="HGNC:HGNC:15997"
                     /db_xref="MIM:607026"
ORIGIN      
        1 mlwprnltsw ddsssvssgi sdtidnlstd dintsssiss yantpassrk nldvqtdaek
       61 hsqvernslw sgddvkksdg gsdsgikmep gskwrrnpsd vsdesdksts gkknpvisqt
      121 gswrrgmtaq vgitmprtka sapagalktp gtgktddakv sekgrlspka sqvkrspsda
      181 grssgdeskk plpsssrtpt anansfgfkk qsgsaaglam itasgvtvts rsatlgkipk
      241 ssalvsrsag rkssmdgaqn qddgylalss rtnlqyrslp rpsksnsrng agnrsstssi
      301 dsnissksag lpvpklreps ktalgsslpg lvnqtdkekg issdnesvas cnsvkvnpaa
      361 qpvsspaqts lqpgakypdv asptlrrlfg gkptkqvpia taenmknsvv isnphatmtq
      421 qgnldspsgs gvlssgsssp lysknvdlnq splasspssa hsapsnsltw gtnassssav
      481 skdglgfqsv sslhtscesi dislssggvp shnsstglia sskddsltpf vrtnsvkttl
      541 sesplsspaa spkfcrstlp rkqdsdphld rntlpkkglr ytptsqlrtq edakewlrsh
      601 sagglqdtaa nspfssgssv tspsgtrfnf sqlaspttvt qmslsnptml rthslsnadg
      661 qydpytdsrf rnssmsldek srtmsrsgsf rdgfeevhgs slslvsstss vystpeekcq
      721 seirklrrel dasqekvsal ttqltanahl vaafeqslgn mtirlqsltm taeqkdseln
      781 elrktiellk kqnaaaqaai ngvintpeln ckgngtaqsa dlrirrqhss dsvssinsat
      841 shssvgsnie sdskkkkrkn wlrssfkqaf gkkkspksas shsdieemtd sslpsspklp
      901 hngstgstpl lrnshsnsli secmdseaet vmqlrnelrd kemkltdirl ealssahqld
      961 qlreamnrmq seieklkaen drlksesqgs gcsrapsqvs isasprqsmg lsqhslnlte
     1021 stsldmlldd tgecsarkeg grhvkivvsf qeemkwkeds rphlfligci gvsgktkwdv
     1081 ldgvvrrlfk eyiihvdpvs qlglnsdsvl gysigeikrs ntsetpellp cgylvgentt
     1141 isvtvkglae nsldslvfes lipkpilqry vslliehrri ilsgpsgtgk tylanrlsey
     1201 ivlregrelt dgviatfnvd hksskelrqy lsnladqcns ennavdmplv iildnlhhvs
     1261 slgeifngll nckyhkcpyi igtmnqatss tpnlqlhhnf rwvlcanhte pvkgflgrfl
     1321 rrklmeteis grvrnmelvk iidwipkvwh hlnrfleahs ssdvtigprl flscpidvdg
     1381 srvwftdlwn ysiipyllea ireglqlygr rapwedpakw vmdtypwaas pqqhewppll
     1441 qlrpedvgfd gysmpregst skqmppsdae gdplmnmlmr lqeaanyssp qsydsdsnsn
     1501 shhddildss lestl
//
LOCUS       XP_054226389            1481 aa            linear   PRI 05-AUG-2025
DEFINITION  neuron navigator 2 isoform X41 [Homo sapiens].
ACCESSION   XP_054226389
VERSION     XP_054226389.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370414.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1481
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1481
                     /product="neuron navigator 2 isoform X41"
                     /calculated_mol_wt=160473
     Region          87..>373
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          <680..>952
                     /region_name="Mplasa_alph_rch"
                     /note="helix-rich Mycoplasma protein; TIGR04523"
                     /db_xref="CDD:275316"
     Region          680..>756
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          <899..>954
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          984..1368
                     /region_name="McrB"
                     /note="5-methylcytosine-specific restriction endonuclease
                     McrBC, GTP-binding regulatory subunit McrB [Defense
                     mechanisms]; COG1401"
                     /db_xref="CDD:441011"
     CDS             1..1481
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /coded_by="XM_054370414.1:18..4463"
                     /db_xref="GeneID:89797"
                     /db_xref="HGNC:HGNC:15997"
                     /db_xref="MIM:607026"
ORIGIN      
        1 mlwprnltsw ddsssvssgi sdtidnlstd dintsssiss yantpassrk nldvqtdaek
       61 hsqvernslw sgddvkksdg gsdsgikmep gskwrrnpsd vsdesdksts gkknpvisqt
      121 gswrrgmtaq vgitmprtka sapagalktp gtgktddakv sekgrlspka sqvkrspsda
      181 grssgdeskk plpsssrtpt anansfgfkk qsgsaaglam itasgvtvts rsatlgkipk
      241 ssalvsrsag rkssmdgaqn qddgylalss rtnlqyrslp rpsksnsrng agnrsstssi
      301 dsnissksag lpvpklreps ktalgsslpg lvnqtdkekg issdnesvas cnsvkvnpaa
      361 qpvsspaqts lqpgakypdv asptlrrlfg gkptkqvpia taenmknsvv isnphatmtq
      421 qgnldspsgs gvlssgsssp lysknvdlnq splasspssa hsapsnsltw gtnassssav
      481 skdglgfqsv sslhtscesi dislssggvp shnsstglia sskddsltpf vrtnsvkttl
      541 serytptsql rtqedakewl rshsagglqd taanspfssg ssvtspsgtr fnfsqlaspt
      601 tvtqmslsnp tmlrthslsn adgqydpytd srfrnssmsl deksrtmsrs gsfrdgfeev
      661 hgsslslvss tssvystpee kcqseirklr reldasqekv salttqltan ahlvaafeqs
      721 lgnmtirlqs ltmtaeqkds elnelrktie llkkqnaaaq aaingvintp elnckgngta
      781 qsadlrirrq hssdsvssin satshssvgs niesdskkkk rknwvnelrs sfkqafgkkk
      841 spksasshsd ieemtdsslp sspklphngs tgstpllrns hsnslisecm dseaetvmql
      901 rnelrdkemk ltdirleals sahqldqlre amnrmqseie klkaendrlk sesqgsgcsr
      961 apsqvsisas prqsmglsqh slnltestsl dmllddtgec sarkeggrhv kivvsfqeem
     1021 kwkedsrphl fligcigvsg ktkwdvldgv vrrlfkeyii hvdpvsqlgl nsdsvlgysi
     1081 geikrsntse tpellpcgyl vgenttisvt vkglaensld slvfeslipk pilqryvsll
     1141 iehrriilsg psgtgktyla nrlseyivlr egreltdgvi atfnvdhkss kelrqylsnl
     1201 adqcnsenna vdmplviild nlhhvsslge ifngllncky hkcpyiigtm nqatsstpnl
     1261 qlhhnfrwvl canhtepvkg flgrflrrkl meteisgrvr nmelvkiidw ipkvwhhlnr
     1321 fleahsssdv tigprlflsc pidvdgsrvw ftdlwnysii pylleaireg lqlygrrapw
     1381 edpakwvmdt ypwaaspqqh ewppllqlrp edvgfdgysm pregstskqm ppsdaegdpl
     1441 mnmlmrlqea anysspqsyd sdsnsnshhd dildsslest l
//
LOCUS       XP_054226390            1478 aa            linear   PRI 05-AUG-2025
DEFINITION  neuron navigator 2 isoform X42 [Homo sapiens].
ACCESSION   XP_054226390
VERSION     XP_054226390.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370415.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1478
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1478
                     /product="neuron navigator 2 isoform X42"
                     /calculated_mol_wt=160131
     Region          87..>373
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     Region          680..>756
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          <896..>951
                     /region_name="COG4372"
                     /note="Uncharacterized protein, contains DUF3084 domain
                     [Function unknown]"
                     /db_xref="CDD:443500"
     Region          981..1365
                     /region_name="McrB"
                     /note="5-methylcytosine-specific restriction endonuclease
                     McrBC, GTP-binding regulatory subunit McrB [Defense
                     mechanisms]; COG1401"
                     /db_xref="CDD:441011"
     CDS             1..1478
                     /gene="NAV2"
                     /gene_synonym="HELAD1; POMFIL2; RAINB1; STEERIN2; UNC53H2"
                     /coded_by="XM_054370415.1:18..4454"
                     /db_xref="GeneID:89797"
                     /db_xref="HGNC:HGNC:15997"
                     /db_xref="MIM:607026"
ORIGIN      
        1 mlwprnltsw ddsssvssgi sdtidnlstd dintsssiss yantpassrk nldvqtdaek
       61 hsqvernslw sgddvkksdg gsdsgikmep gskwrrnpsd vsdesdksts gkknpvisqt
      121 gswrrgmtaq vgitmprtka sapagalktp gtgktddakv sekgrlspka sqvkrspsda
      181 grssgdeskk plpsssrtpt anansfgfkk qsgsaaglam itasgvtvts rsatlgkipk
      241 ssalvsrsag rkssmdgaqn qddgylalss rtnlqyrslp rpsksnsrng agnrsstssi
      301 dsnissksag lpvpklreps ktalgsslpg lvnqtdkekg issdnesvas cnsvkvnpaa
      361 qpvsspaqts lqpgakypdv asptlrrlfg gkptkqvpia taenmknsvv isnphatmtq
      421 qgnldspsgs gvlssgsssp lysknvdlnq splasspssa hsapsnsltw gtnassssav
      481 skdglgfqsv sslhtscesi dislssggvp shnsstglia sskddsltpf vrtnsvkttl
      541 serytptsql rtqedakewl rshsagglqd taanspfssg ssvtspsgtr fnfsqlaspt
      601 tvtqmslsnp tmlrthslsn adgqydpytd srfrnssmsl deksrtmsrs gsfrdgfeev
      661 hgsslslvss tssvystpee kcqseirklr reldasqekv salttqltan ahlvaafeqs
      721 lgnmtirlqs ltmtaeqkds elnelrktie llkkqnaaaq aaingvintp elnckgngta
      781 qsadlrirrq hssdsvssin satshssvgs niesdskkkk rknwlrssfk qafgkkkspk
      841 sasshsdiee mtdsslpssp klphngstgs tpllrnshsn slisecmdse aetvmqlrne
      901 lrdkemkltd irlealssah qldqlreamn rmqseieklk aendrlkses qgsgcsraps
      961 qvsisasprq smglsqhsln ltestsldml lddtgecsar keggrhvkiv vsfqeemkwk
     1021 edsrphlfli gcigvsgktk wdvldgvvrr lfkeyiihvd pvsqlglnsd svlgysigei
     1081 krsntsetpe llpcgylvge nttisvtvkg laensldslv feslipkpil qryvsllieh
     1141 rriilsgpsg tgktylanrl seyivlregr eltdgviatf nvdhksskel rqylsnladq
     1201 cnsennavdm plviildnlh hvsslgeifn gllnckyhkc pyiigtmnqa tsstpnlqlh
     1261 hnfrwvlcan htepvkgflg rflrrklmet eisgrvrnme lvkiidwipk vwhhlnrfle
     1321 ahsssdvtig prlflscpid vdgsrvwftd lwnysiipyl leaireglql ygrrapwedp
     1381 akwvmdtypw aaspqqhewp pllqlrpedv gfdgysmpre gstskqmpps daegdplmnm
     1441 lmrlqeaany sspqsydsds nsnshhddil dsslestl
//
LOCUS       XP_054226391             604 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Atg16l2 isoform X1 [Homo sapiens].
ACCESSION   XP_054226391
VERSION     XP_054226391.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370416.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..604
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..604
                     /product="protein Atg16l2 isoform X1"
                     /calculated_mol_wt=67465
     Region          32..203
                     /region_name="ATG16"
                     /note="Autophagy protein 16 (ATG16); pfam08614"
                     /db_xref="CDD:462536"
     Region          <121..>295
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          331..588
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cd00200"
                     /db_xref="CDD:238121"
     Site            order(335,353,357,363..364,378..379,397,401,407..408,
                     420..421,438,443,449..450,462,477,482,488..489,501,519,
                     523,529..530,542..543,564,569,575..576,588)
                     /site_type="active"
                     /note="structural tetrad [active]"
                     /db_xref="CDD:238121"
     Region          341..378
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          384..420
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          425..461
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          467..499
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          505..543
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          551..587
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..604
                     /gene="ATG16L2"
                     /gene_synonym="ATG16B; WDR80"
                     /coded_by="XM_054370416.1:36..1850"
                     /db_xref="GeneID:89849"
                     /db_xref="HGNC:HGNC:25464"
                     /db_xref="MIM:618716"
ORIGIN      
        1 magpgvpgap aarwkrhivr qlrlrdrtqk alflelvpay nhllekaell dkfskklqpe
       61 pnsvtptthq gpweeselds dqvpslvalr vkwqeeeegl rlvcgemayq vvekgaalgt
      121 leselqqrqs rlaalearva qlrearaqqa qqveewraqn avqraayeal rahvglreaa
      181 lrrlqeeard llerlvqrka raaaernlrn errerakqar vsqelkkaak rtvsisegpd
      241 tlgdgmrerr etlalapepe plekeacekw krpfrsasat sltlshcvdv vkglldfkkr
      301 rghsiggape qryqiipvcv aarlptraqd vldahlsevn avrfgpnssl latggadrli
      361 hlwnvvgsrl eanqtlegag gsitsvdfdp sgyqvlaaty nqaaqlwkvg eaqsketlsg
      421 hkdkvtaakf kltrhqavtg srdrtvkewd lgraycsrti nvlsycndvv cgdhiiisgh
      481 ndqkirfwds rgphctqvip vqgrvtslsl shdqlhllsc srdntlkvid lrvsnirqvf
      541 radgfkcgsd wtkavfspdr syalagscdg alyiwdvdtg klesrlqgph wylnlshpws
      601 vtif
//
LOCUS       XP_054226392             598 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Atg16l2 isoform X2 [Homo sapiens].
ACCESSION   XP_054226392
VERSION     XP_054226392.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370417.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..598
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..598
                     /product="protein Atg16l2 isoform X2"
                     /calculated_mol_wt=66700
     Region          32..203
                     /region_name="ATG16"
                     /note="Autophagy protein 16 (ATG16); pfam08614"
                     /db_xref="CDD:462536"
     Region          310..598
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cd00200"
                     /db_xref="CDD:238121"
     Site            order(314,332,336,342..343,357..358,376,380,386..387,
                     399..400,417,422,428..429,441,456,461,467..468,480,498,
                     502,508..509,521..522,543,548,554..555,567,569,587,591,
                     597..598)
                     /site_type="active"
                     /note="structural tetrad [active]"
                     /db_xref="CDD:238121"
     Region          320..357
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          363..399
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          404..440
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          446..478
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          484..522
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          530..566
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..598
                     /gene="ATG16L2"
                     /gene_synonym="ATG16B; WDR80"
                     /coded_by="XM_054370417.1:36..1832"
                     /db_xref="GeneID:89849"
                     /db_xref="HGNC:HGNC:25464"
                     /db_xref="MIM:618716"
ORIGIN      
        1 magpgvpgap aarwkrhivr qlrlrdrtqk alflelvpay nhllekaell dkfskklqpe
       61 pnsvtptthq gpweeselds dqvpslvalr vkwqeeeegl rlvcgemayq vvekgaalgt
      121 leselqqrqs rlaalearva qlrearaqqa qqveewraqn avqraayeal rahvglreaa
      181 lrrlqeeard llerlvqrka raaaernlrn errerakqar vsqelkkaak rtvsisegpd
      241 tlgdgmrerr etlalapepe plekeacekw krpfsfkkrr ghsiggapeq ryqiipvcva
      301 arlptraqdv ldahlsevna vrfgpnssll atggadrlih lwnvvgsrle anqtlegagg
      361 sitsvdfdps gyqvlaatyn qaaqlwkvge aqsketlsgh kdkvtaakfk ltrhqavtgs
      421 rdrtvkewdl graycsrtin vlsycndvvc gdhiiisghn dqkirfwdsr gphctqvipv
      481 qgrvtslsls hdqlhllscs rdntlkvidl rvsnirqvfr adgfkcgsdw tkavfspdrs
      541 yalagscdga lyiwdvdtgk lesrlqgphc aavnavawcy sgshmvsvdq grkvvlwq
//
LOCUS       XP_054226393             581 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Atg16l2 isoform X3 [Homo sapiens].
ACCESSION   XP_054226393
VERSION     XP_054226393.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370418.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..581
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..581
                     /product="protein Atg16l2 isoform X3"
                     /calculated_mol_wt=64475
     Region          32..203
                     /region_name="ATG16"
                     /note="Autophagy protein 16 (ATG16); pfam08614"
                     /db_xref="CDD:462536"
     Region          293..581
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cd00200"
                     /db_xref="CDD:238121"
     Site            order(297,315,319,325..326,340..341,359,363,369..370,
                     382..383,400,405,411..412,424,439,444,450..451,463,481,
                     485,491..492,504..505,526,531,537..538,550,552,570,574,
                     580..581)
                     /site_type="active"
                     /note="structural tetrad [active]"
                     /db_xref="CDD:238121"
     Region          303..340
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          346..382
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          387..423
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          429..461
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          467..505
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          513..549
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..581
                     /gene="ATG16L2"
                     /gene_synonym="ATG16B; WDR80"
                     /coded_by="XM_054370418.1:36..1781"
                     /db_xref="GeneID:89849"
                     /db_xref="HGNC:HGNC:25464"
                     /db_xref="MIM:618716"
ORIGIN      
        1 magpgvpgap aarwkrhivr qlrlrdrtqk alflelvpay nhllekaell dkfskklqpe
       61 pnsvtptthq gpweeselds dqvpslvalr vkwqeeeegl rlvcgemayq vvekgaalgt
      121 leselqqrqs rlaalearva qlrearaqqa qqveewraqn avqraayeal rahvglreaa
      181 lrrlqeeard llerlvqrka raaaernlrn errerakqar vsqelkkaak rtvsisesas
      241 atsltlshcv dvvkglldfk krrghsigga peqryqiipv cvaarlptra qdvldahlse
      301 vnavrfgpns sllatggadr lihlwnvvgs rleanqtleg aggsitsvdf dpsgyqvlaa
      361 tynqaaqlwk vgeaqsketl sghkdkvtaa kfkltrhqav tgsrdrtvke wdlgraycsr
      421 tinvlsycnd vvcgdhiiis ghndqkirfw dsrgphctqv ipvqgrvtsl slshdqlhll
      481 scsrdntlkv idlrvsnirq vfradgfkcg sdwtkavfsp drsyalagsc dgalyiwdvd
      541 tgklesrlqg phcaavnava wcysgshmvs vdqgrkvvlw q
//
LOCUS       XP_054226394             566 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Atg16l2 isoform X4 [Homo sapiens].
ACCESSION   XP_054226394
VERSION     XP_054226394.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370419.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..566
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..566
                     /product="protein Atg16l2 isoform X4"
                     /calculated_mol_wt=63073
     Region          32..203
                     /region_name="ATG16"
                     /note="Autophagy protein 16 (ATG16); pfam08614"
                     /db_xref="CDD:462536"
     Region          293..550
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cd00200"
                     /db_xref="CDD:238121"
     Site            order(297,315,319,325..326,340..341,359,363,369..370,
                     382..383,400,405,411..412,424,439,444,450..451,463,481,
                     485,491..492,504..505,526,531,537..538,550)
                     /site_type="active"
                     /note="structural tetrad [active]"
                     /db_xref="CDD:238121"
     Region          303..340
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          346..382
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          387..423
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          429..461
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          467..505
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          513..549
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..566
                     /gene="ATG16L2"
                     /gene_synonym="ATG16B; WDR80"
                     /coded_by="XM_054370419.1:36..1736"
                     /db_xref="GeneID:89849"
                     /db_xref="HGNC:HGNC:25464"
                     /db_xref="MIM:618716"
ORIGIN      
        1 magpgvpgap aarwkrhivr qlrlrdrtqk alflelvpay nhllekaell dkfskklqpe
       61 pnsvtptthq gpweeselds dqvpslvalr vkwqeeeegl rlvcgemayq vvekgaalgt
      121 leselqqrqs rlaalearva qlrearaqqa qqveewraqn avqraayeal rahvglreaa
      181 lrrlqeeard llerlvqrka raaaernlrn errerakqar vsqelkkaak rtvsisesas
      241 atsltlshcv dvvkglldfk krrghsigga peqryqiipv cvaarlptra qdvldahlse
      301 vnavrfgpns sllatggadr lihlwnvvgs rleanqtleg aggsitsvdf dpsgyqvlaa
      361 tynqaaqlwk vgeaqsketl sghkdkvtaa kfkltrhqav tgsrdrtvke wdlgraycsr
      421 tinvlsycnd vvcgdhiiis ghndqkirfw dsrgphctqv ipvqgrvtsl slshdqlhll
      481 scsrdntlkv idlrvsnirq vfradgfkcg sdwtkavfsp drsyalagsc dgalyiwdvd
      541 tgklesrlqg phwylnlshp wsvtif
//
LOCUS       XP_054226395             513 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Atg16l2 isoform X5 [Homo sapiens].
ACCESSION   XP_054226395
VERSION     XP_054226395.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370420.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..513
                     /product="protein Atg16l2 isoform X5"
                     /calculated_mol_wt=56824
     Region          <1..97
                     /region_name="ATG16"
                     /note="Autophagy protein 16 (ATG16); pfam08614"
                     /db_xref="CDD:462536"
     Region          <15..>189
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          225..513
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cd00200"
                     /db_xref="CDD:238121"
     Site            order(229,247,251,257..258,272..273,291,295,301..302,
                     314..315,332,337,343..344,356,371,376,382..383,395,413,
                     417,423..424,436..437,458,463,469..470,482,484,502,506,
                     512..513)
                     /site_type="active"
                     /note="structural tetrad [active]"
                     /db_xref="CDD:238121"
     Region          235..272
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          278..314
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          319..355
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          361..393
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          399..437
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          445..481
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..513
                     /gene="ATG16L2"
                     /gene_synonym="ATG16B; WDR80"
                     /coded_by="XM_054370420.1:560..2101"
                     /db_xref="GeneID:89849"
                     /db_xref="HGNC:HGNC:25464"
                     /db_xref="MIM:618716"
ORIGIN      
        1 mayqvvekga algtleselq qrqsrlaale arvaqlrear aqqaqqveew raqnavqraa
       61 yealrahvgl reaalrrlqe eardllerlv qrkaraaaer nlrnerrera kqarvsqelk
      121 kaakrtvsis egpdtlgdgm rerretlala pepeplekea cekwkrpfrs asatsltlsh
      181 cvdvvkglld fkkrrghsig gapeqryqii pvcvaarlpt raqdvldahl sevnavrfgp
      241 nssllatgga drlihlwnvv gsrleanqtl egaggsitsv dfdpsgyqvl aatynqaaql
      301 wkvgeaqske tlsghkdkvt aakfkltrhq avtgsrdrtv kewdlgrayc srtinvlsyc
      361 ndvvcgdhii isghndqkir fwdsrgphct qvipvqgrvt slslshdqlh llscsrdntl
      421 kvidlrvsni rqvfradgfk cgsdwtkavf spdrsyalag scdgalyiwd vdtgklesrl
      481 qgphcaavna vawcysgshm vsvdqgrkvv lwq
//
LOCUS       XP_054226396             472 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Atg16l2 isoform X6 [Homo sapiens].
ACCESSION   XP_054226396
VERSION     XP_054226396.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370421.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..472
                     /product="protein Atg16l2 isoform X6"
                     /calculated_mol_wt=52399
     Region          32..203
                     /region_name="ATG16"
                     /note="Autophagy protein 16 (ATG16); pfam08614"
                     /db_xref="CDD:462536"
     Region          <121..>295
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          <331..466
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          340..378
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          383..419
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..472
                     /gene="ATG16L2"
                     /gene_synonym="ATG16B; WDR80"
                     /coded_by="XM_054370421.1:36..1454"
                     /db_xref="GeneID:89849"
                     /db_xref="HGNC:HGNC:25464"
                     /db_xref="MIM:618716"
ORIGIN      
        1 magpgvpgap aarwkrhivr qlrlrdrtqk alflelvpay nhllekaell dkfskklqpe
       61 pnsvtptthq gpweeselds dqvpslvalr vkwqeeeegl rlvcgemayq vvekgaalgt
      121 leselqqrqs rlaalearva qlrearaqqa qqveewraqn avqraayeal rahvglreaa
      181 lrrlqeeard llerlvqrka raaaernlrn errerakqar vsqelkkaak rtvsisegpd
      241 tlgdgmrerr etlalapepe plekeacekw krpfrsasat sltlshcvdv vkglldfkkr
      301 rghsiggape qryqiipvcv aarlptraqd vldahlsevn avrfgpnssl latggadrli
      361 hlwnvvgsrl eanqtlegag gsitsvdfdp sgyqvlaaty nqaaqlwkvg eaqsketlsg
      421 hkdkvtaakf kltrhqavtg srdrtvkewd lgraywgpta prsslcrags pp
//
LOCUS       XP_054226397             513 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Atg16l2 isoform X5 [Homo sapiens].
ACCESSION   XP_054226397
VERSION     XP_054226397.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370422.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..513
                     /product="protein Atg16l2 isoform X5"
                     /calculated_mol_wt=56824
     Region          <1..97
                     /region_name="ATG16"
                     /note="Autophagy protein 16 (ATG16); pfam08614"
                     /db_xref="CDD:462536"
     Region          <15..>189
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Region          225..513
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cd00200"
                     /db_xref="CDD:238121"
     Site            order(229,247,251,257..258,272..273,291,295,301..302,
                     314..315,332,337,343..344,356,371,376,382..383,395,413,
                     417,423..424,436..437,458,463,469..470,482,484,502,506,
                     512..513)
                     /site_type="active"
                     /note="structural tetrad [active]"
                     /db_xref="CDD:238121"
     Region          235..272
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          278..314
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          319..355
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          361..393
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          399..437
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          445..481
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..513
                     /gene="ATG16L2"
                     /gene_synonym="ATG16B; WDR80"
                     /coded_by="XM_054370422.1:219..1760"
                     /db_xref="GeneID:89849"
                     /db_xref="HGNC:HGNC:25464"
                     /db_xref="MIM:618716"
ORIGIN      
        1 mayqvvekga algtleselq qrqsrlaale arvaqlrear aqqaqqveew raqnavqraa
       61 yealrahvgl reaalrrlqe eardllerlv qrkaraaaer nlrnerrera kqarvsqelk
      121 kaakrtvsis egpdtlgdgm rerretlala pepeplekea cekwkrpfrs asatsltlsh
      181 cvdvvkglld fkkrrghsig gapeqryqii pvcvaarlpt raqdvldahl sevnavrfgp
      241 nssllatgga drlihlwnvv gsrleanqtl egaggsitsv dfdpsgyqvl aatynqaaql
      301 wkvgeaqske tlsghkdkvt aakfkltrhq avtgsrdrtv kewdlgrayc srtinvlsyc
      361 ndvvcgdhii isghndqkir fwdsrgphct qvipvqgrvt slslshdqlh llscsrdntl
      421 kvidlrvsni rqvfradgfk cgsdwtkavf spdrsyalag scdgalyiwd vdtgklesrl
      481 qgphcaavna vawcysgshm vsvdqgrkvv lwq
//
LOCUS       XP_054226398             340 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Atg16l2 isoform X7 [Homo sapiens].
ACCESSION   XP_054226398
VERSION     XP_054226398.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370423.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..340
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..340
                     /product="protein Atg16l2 isoform X7"
                     /calculated_mol_wt=38343
     Region          32..203
                     /region_name="ATG16"
                     /note="Autophagy protein 16 (ATG16); pfam08614"
                     /db_xref="CDD:462536"
     CDS             1..340
                     /gene="ATG16L2"
                     /gene_synonym="ATG16B; WDR80"
                     /coded_by="XM_054370423.1:36..1058"
                     /db_xref="GeneID:89849"
                     /db_xref="HGNC:HGNC:25464"
                     /db_xref="MIM:618716"
ORIGIN      
        1 magpgvpgap aarwkrhivr qlrlrdrtqk alflelvpay nhllekaell dkfskklqpe
       61 pnsvtptthq gpweeselds dqvpslvalr vkwqeeeegl rlvcgemayq vvekgaalgt
      121 leselqqrqs rlaalearva qlrearaqqa qqveewraqn avqraayeal rahvglreaa
      181 lrrlqeeard llerlvqrka raaaernlrn errerakqar vsqelkkaak rtvsisegpd
      241 tlgdgmrerr etlalapepe plekeacekw krpfrsasat sltlshcvdv vkglldfkkr
      301 rghsiggape qryqiipvcv aarlptraqd vlqppghwrg
//
LOCUS       XP_054226399             334 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Atg16l2 isoform X8 [Homo sapiens].
ACCESSION   XP_054226399
VERSION     XP_054226399.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370424.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..334
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..334
                     /product="protein Atg16l2 isoform X8"
                     /calculated_mol_wt=36659
     Region          46..93
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          64..334
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cd00200"
                     /db_xref="CDD:238121"
     Site            order(68,72,78..79,93..94,112,116,122..123,135..136,153,
                     158,164..165,177,192,197,203..204,216,234,238,244..245,
                     257..258,279,284,290..291,303,305,323,327,333..334)
                     /site_type="active"
                     /note="structural tetrad [active]"
                     /db_xref="CDD:238121"
     Region          99..135
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          140..176
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          182..214
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          220..258
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          266..302
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..334
                     /gene="ATG16L2"
                     /gene_synonym="ATG16B; WDR80"
                     /coded_by="XM_054370424.1:2104..3108"
                     /db_xref="GeneID:89849"
                     /db_xref="HGNC:HGNC:25464"
                     /db_xref="MIM:618716"
ORIGIN      
        1 mpqgswrlpp ekdllnallt pthltpvlrr gevtqlgepl ssdtrsslcv wlpdflpglr
       61 mccsllatgg adrlihlwnv vgsrleanqt legaggsits vdfdpsgyqv laatynqaaq
      121 lwkvgeaqsk etlsghkdkv taakfkltrh qavtgsrdrt vkewdlgray csrtinvlsy
      181 cndvvcgdhi iisghndqki rfwdsrgphc tqvipvqgrv tslslshdql hllscsrdnt
      241 lkvidlrvsn irqvfradgf kcgsdwtkav fspdrsyala gscdgalyiw dvdtgklesr
      301 lqgphcaavn avawcysgsh mvsvdqgrkv vlwq
//
LOCUS       XP_054226400             334 aa            linear   PRI 05-AUG-2025
DEFINITION  protein Atg16l2 isoform X8 [Homo sapiens].
ACCESSION   XP_054226400
VERSION     XP_054226400.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370425.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..334
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..334
                     /product="protein Atg16l2 isoform X8"
                     /calculated_mol_wt=36659
     Region          46..93
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          64..334
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cd00200"
                     /db_xref="CDD:238121"
     Site            order(68,72,78..79,93..94,112,116,122..123,135..136,153,
                     158,164..165,177,192,197,203..204,216,234,238,244..245,
                     257..258,279,284,290..291,303,305,323,327,333..334)
                     /site_type="active"
                     /note="structural tetrad [active]"
                     /db_xref="CDD:238121"
     Region          99..135
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          140..176
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          182..214
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          220..258
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          266..302
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..334
                     /gene="ATG16L2"
                     /gene_synonym="ATG16B; WDR80"
                     /coded_by="XM_054370425.1:1842..2846"
                     /db_xref="GeneID:89849"
                     /db_xref="HGNC:HGNC:25464"
                     /db_xref="MIM:618716"
ORIGIN      
        1 mpqgswrlpp ekdllnallt pthltpvlrr gevtqlgepl ssdtrsslcv wlpdflpglr
       61 mccsllatgg adrlihlwnv vgsrleanqt legaggsits vdfdpsgyqv laatynqaaq
      121 lwkvgeaqsk etlsghkdkv taakfkltrh qavtgsrdrt vkewdlgray csrtinvlsy
      181 cndvvcgdhi iisghndqki rfwdsrgphc tqvipvqgrv tslslshdql hllscsrdnt
      241 lkvidlrvsn irqvfradgf kcgsdwtkav fspdrsyala gscdgalyiw dvdtgklesr
      301 lqgphcaavn avawcysgsh mvsvdqgrkv vlwq
//
LOCUS       XP_054226401             717 aa            linear   PRI 05-AUG-2025
DEFINITION  ribosomal protein S6 kinase alpha-4 isoform X1 [Homo sapiens].
ACCESSION   XP_054226401
VERSION     XP_054226401.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370426.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..717
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..717
                     /product="ribosomal protein S6 kinase alpha-4 isoform X1"
                     /calculated_mol_wt=79389
     Region          32..308
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Site            order(39..42,45,47,63,65,99,115..118,161,165..166,168,
                     178..179)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270870"
     Region          349..659
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Site            order(362..365,368,370,383,385,412,428..431,475,479..480,
                     482,495..496)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271082"
     CDS             1..717
                     /gene="RPS6KA4"
                     /gene_synonym="MSK2; RSK-B; S6K-alpha-4"
                     /coded_by="XM_054370426.1:75..2228"
                     /db_xref="GeneID:8986"
                     /db_xref="HGNC:HGNC:10433"
                     /db_xref="MIM:603606"
ORIGIN      
        1 mgdedddesc avelritean ltgheekvsv enfellkvlg tgaygkvflv rkagghdagk
       61 lyamkvlrka alvqraktqe htrtersvle lvrqapflvt lhyafqtdak lhlildyvsg
      121 gemfthlyqr qyfkeaevrv yggeivlale hlhklgiiyr dlklenvlld seghivltdf
      181 glskefltee kertfsfcgt ieymapeiir sktghgkavd wwslgillfe lltgaspftl
      241 egerntqaev srrilkcspp fpprigpvaq dllqrllckd pkkrlgagpq gaqevrnhpf
      301 fqgysfvaps ilfdhnnavm tdgleapgag drpgraavar sammqdspff qqyeldlrep
      361 algqgsfsvc rrcrqrqsgq efavkilsrr leantqreva alrlcqshpn vvnlhevhhd
      421 qlhtylvlel lrggellehi rkkrhfsese asqilrslvs avsfmheeag vvhrdlkpen
      481 ilyaddtpga pvkiidfgfa rlrpqspgvp mqtpcftlqy aapellaqqg ydescdlwsl
      541 gvilymmlsg qvpfqgasgq ggqsqaaeim ckiregrfsl dgeawqgvse eakelvrgll
      601 tvdpakrlkl eglrgsswlq dgsarssppl rtpdvlessg pavrsglnat fmafnrgkre
      661 gfflksvena plakrrkqkl rsatasrrgs papanpgrap vaskgaprra ngplpps
//
LOCUS       XP_054226402             711 aa            linear   PRI 05-AUG-2025
DEFINITION  ribosomal protein S6 kinase alpha-4 isoform X2 [Homo sapiens].
ACCESSION   XP_054226402
VERSION     XP_054226402.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370427.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..711
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..711
                     /product="ribosomal protein S6 kinase alpha-4 isoform X2"
                     /calculated_mol_wt=78667
     Region          32..308
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Site            order(39..42,45,47,63,65,99,115..118,161,165..166,168,
                     178..179)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270765"
     Region          345..653
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Site            order(356..359,362,364,377,379,406,422..425,469,473..474,
                     476,489..490)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271082"
     CDS             1..711
                     /gene="RPS6KA4"
                     /gene_synonym="MSK2; RSK-B; S6K-alpha-4"
                     /coded_by="XM_054370427.1:75..2210"
                     /db_xref="GeneID:8986"
                     /db_xref="HGNC:HGNC:10433"
                     /db_xref="MIM:603606"
ORIGIN      
        1 mgdedddesc avelritean ltgheekvsv enfellkvlg tgaygkvflv rkagghdagk
       61 lyamkvlrka alvqraktqe htrtersvle lvrqapflvt lhyafqtdak lhlildyvsg
      121 gemfthlyqr qyfkeaevrv yggeivlale hlhklgiiyr dlklenvlld seghivltdf
      181 glskefltee kertfsfcgt ieymapeiir sktghgkavd wwslgillfe lltgaspftl
      241 egerntqaev srrilkcspp fpprigpvaq dllqrllckd pkkrlgagpq gaqevrnhpf
      301 fqgysfvaps ilfdhnnavm tdgleapgag drpgraavar sammqqyeld lrepalgqgs
      361 fsvcrrcrqr qsgqefavki lsrrleantq revaalrlcq shpnvvnlhe vhhdqlhtyl
      421 vlellrggel lehirkkrhf seseasqilr slvsavsfmh eeagvvhrdl kpenilyadd
      481 tpgapvkiid fgfarlrpqs pgvpmqtpcf tlqyaapell aqqgydescd lwslgvilym
      541 mlsgqvpfqg asgqggqsqa aeimckireg rfsldgeawq gvseeakelv rglltvdpak
      601 rlkleglrgs swlqdgsars spplrtpdvl essgpavrsg lnatfmafnr gkregfflks
      661 venaplakrr kqklrsatas rrgspapanp grapvaskga prrangplpp s
//
LOCUS       XP_054226403             710 aa            linear   PRI 05-AUG-2025
DEFINITION  ribosomal protein S6 kinase alpha-4 isoform X3 [Homo sapiens].
ACCESSION   XP_054226403
VERSION     XP_054226403.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370428.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..710
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..710
                     /product="ribosomal protein S6 kinase alpha-4 isoform X3"
                     /calculated_mol_wt=78539
     Region          32..308
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Site            order(39..42,45,47,63,65,99,115..118,161,165..166,168,
                     178..179)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270765"
     Region          345..652
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Site            order(355..358,361,363,376,378,405,421..424,468,472..473,
                     475,488..489)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271082"
     CDS             1..710
                     /gene="RPS6KA4"
                     /gene_synonym="MSK2; RSK-B; S6K-alpha-4"
                     /coded_by="XM_054370428.1:75..2207"
                     /db_xref="GeneID:8986"
                     /db_xref="HGNC:HGNC:10433"
                     /db_xref="MIM:603606"
ORIGIN      
        1 mgdedddesc avelritean ltgheekvsv enfellkvlg tgaygkvflv rkagghdagk
       61 lyamkvlrka alvqraktqe htrtersvle lvrqapflvt lhyafqtdak lhlildyvsg
      121 gemfthlyqr qyfkeaevrv yggeivlale hlhklgiiyr dlklenvlld seghivltdf
      181 glskefltee kertfsfcgt ieymapeiir sktghgkavd wwslgillfe lltgaspftl
      241 egerntqaev srrilkcspp fpprigpvaq dllqrllckd pkkrlgagpq gaqevrnhpf
      301 fqgysfvaps ilfdhnnavm tdgleapgag drpgraavar sammqyeldl repalgqgsf
      361 svcrrcrqrq sgqefavkil srrleantqr evaalrlcqs hpnvvnlhev hhdqlhtylv
      421 lellrggell ehirkkrhfs eseasqilrs lvsavsfmhe eagvvhrdlk penilyaddt
      481 pgapvkiidf gfarlrpqsp gvpmqtpcft lqyaapella qqgydescdl wslgvilymm
      541 lsgqvpfqga sgqggqsqaa eimckiregr fsldgeawqg vseeakelvr glltvdpakr
      601 lkleglrgss wlqdgsarss pplrtpdvle ssgpavrsgl natfmafnrg kregfflksv
      661 enaplakrrk qklrsatasr rgspapanpg rapvaskgap rrangplpps
//
LOCUS       XP_054226404             387 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-8 isoform X1 [Homo sapiens].
ACCESSION   XP_054226404
VERSION     XP_054226404.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370429.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..387
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..387
                     /product="synaptotagmin-8 isoform X1"
                     /calculated_mol_wt=42312
     Region          105..218
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     Region          233..362
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     CDS             1..387
                     /gene="SYT8"
                     /coded_by="XM_054370429.1:89..1252"
                     /db_xref="GeneID:90019"
                     /db_xref="HGNC:HGNC:19264"
                     /db_xref="MIM:607719"
ORIGIN      
        1 mghppvspsa papagttaip glipdlvagt pwprwaliag alaagvllvs cllcaacccc
       61 rrhrkkprdk esvglgsarg tttthlvqpd vdglesspgd aqqwgrlqls lefdfgsqei
      121 rvglrqaadl rpggtvdpya rvsvstqagh rhetkvhrgt lcpvfdetcc fhipqaelpg
      181 atlqvqlfnf krfsgheplg elrlplgtvd lqhvlehwyl lgppaatqpe qvgelcfslr
      241 yvpssgrltv vvlearglrp glaepyvkvq lmlnqrkwkk rktatkkgta apyfneaftf
      301 lvpfsqvqnv dlvlavwdrs lplltepvgk vhlgarasgq plqhwadmla harrpiaqrh
      361 plrparevdr mlalqprlrl rlplphs
//
LOCUS       XP_054226405             387 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-8 isoform X1 [Homo sapiens].
ACCESSION   XP_054226405
VERSION     XP_054226405.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370430.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..387
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..387
                     /product="synaptotagmin-8 isoform X1"
                     /calculated_mol_wt=42312
     Region          105..218
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     Region          233..362
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     CDS             1..387
                     /gene="SYT8"
                     /coded_by="XM_054370430.1:129..1292"
                     /db_xref="GeneID:90019"
                     /db_xref="HGNC:HGNC:19264"
                     /db_xref="MIM:607719"
ORIGIN      
        1 mghppvspsa papagttaip glipdlvagt pwprwaliag alaagvllvs cllcaacccc
       61 rrhrkkprdk esvglgsarg tttthlvqpd vdglesspgd aqqwgrlqls lefdfgsqei
      121 rvglrqaadl rpggtvdpya rvsvstqagh rhetkvhrgt lcpvfdetcc fhipqaelpg
      181 atlqvqlfnf krfsgheplg elrlplgtvd lqhvlehwyl lgppaatqpe qvgelcfslr
      241 yvpssgrltv vvlearglrp glaepyvkvq lmlnqrkwkk rktatkkgta apyfneaftf
      301 lvpfsqvqnv dlvlavwdrs lplltepvgk vhlgarasgq plqhwadmla harrpiaqrh
      361 plrparevdr mlalqprlrl rlplphs
//
LOCUS       XP_054226406             280 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-8 isoform X2 [Homo sapiens].
ACCESSION   XP_054226406
VERSION     XP_054226406.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370431.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..280
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..280
                     /product="synaptotagmin-8 isoform X2"
                     /calculated_mol_wt=29567
     Region          105..218
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     Region          233..>259
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     CDS             1..280
                     /gene="SYT8"
                     /coded_by="XM_054370431.1:94..936"
                     /db_xref="GeneID:90019"
                     /db_xref="HGNC:HGNC:19264"
                     /db_xref="MIM:607719"
ORIGIN      
        1 mghppvspsa papagttaip glipdlvagt pwprwaliag alaagvllvs cllcaacccc
       61 rrhrkkprdk esvglgsarg tttthlvqpd vdglesspgd aqqwgrlqls lefdfgsqei
      121 rvglrqaadl rpggtvdpya rvsvstqagh rhetkvhrgt lcpvfdetcc fhipqaelpg
      181 atlqvqlfnf krfsgheplg elrlplgtvd lqhvlehwyl lgppaatqpe qvgelcfslr
      241 yvpssgrltv vvlearglrp glaecgpgag clgpqpaapn
//
LOCUS       XP_054226407             294 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-8 isoform X3 [Homo sapiens].
ACCESSION   XP_054226407
VERSION     XP_054226407.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370432.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..294
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..294
                     /product="synaptotagmin-8 isoform X3"
                     /calculated_mol_wt=31104
     Region          119..232
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     Region          247..>273
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     CDS             1..294
                     /gene="SYT8"
                     /coded_by="XM_054370432.1:159..1043"
                     /db_xref="GeneID:90019"
                     /db_xref="HGNC:HGNC:19264"
                     /db_xref="MIM:607719"
ORIGIN      
        1 magkpwwapa vgrkmghppv spsapapagt taipglipdl vagtpwprwa liagalaagv
       61 llvscllcaa ccccrrhrkk prdkesvglg sargtttthl vqpdvdgles spgdaqqwgr
      121 lqlslefdfg sqeirvglrq aadlrpggtv dpyarvsvst qaghrhetkv hrgtlcpvfd
      181 etccfhipqa elpgatlqvq lfnfkrfsgh eplgelrlpl gtvdlqhvle hwyllgppaa
      241 tqpeqvgelc fslryvpssg rltvvvlear glrpglaecg pgagclgpqp aapn
//
LOCUS       XP_054226408             895 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase BRSK2 isoform X27 [Homo sapiens].
ACCESSION   XP_054226408
VERSION     XP_054226408.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370433.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..895
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..895
                     /product="serine/threonine-protein kinase BRSK2 isoform
                     X27"
                     /calculated_mol_wt=98085
     Region          46..285
                     /region_name="STKc_BRSK1_2"
                     /note="Catalytic domain of Brain-specific
                     serine/threonine-protein kinases 1 and 2; cd14081"
                     /db_xref="CDD:270983"
     Site            order(48,61,63,94,110..113,117,119..120,122,155..156,158,
                     160..161,163,173..174,177,191..195,197,227..230)
                     /site_type="active"
                     /db_xref="CDD:270983"
     Site            order(117,119..120,122,156,158,160,177,191..195,197,
                     227..230)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270983"
     Site            order(173..184,186..195)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270983"
     Region          312..365
                     /region_name="UBA_BRSK"
                     /note="UBA domain found in serine/threonine-protein kinase
                     BRSK1, BRSK2 and similar proteins; cd14340"
                     /db_xref="CDD:270525"
     CDS             1..895
                     /gene="BRSK2"
                     /gene_synonym="C11orf7; PEN11B; SAD-A; SAD1; SADA; STK29"
                     /coded_by="XM_054370433.1:67..2754"
                     /db_xref="GeneID:9024"
                     /db_xref="HGNC:HGNC:11405"
                     /db_xref="MIM:609236"
ORIGIN      
        1 mragchvsvv ppqsfrnhrd gepagdtgfl sapaapkaeg ralraglvkl gvhcvtcqkv
       61 aikivnrekl sesvlmkver eiailklieh phvlklhdvy enkkylylvl ehvsggelfd
      121 ylvkkgrltp kearkffrqi isaldfchsh sichrdlkpe nllldeknni riadfgmasl
      181 qvgdsllets cgsphyacpe virgekydgr kadvwscgvi lfallvgalp fdddnlrqll
      241 ekvkrgvfhm phfippdcqs llrgmievda arrltlehiq khiwyiggkn epepeqpipr
      301 kvqirslpsl edidpdvlds mhslgcfrdr nkllqdllse eenqekmiyf llldrkeryp
      361 sqededlppr neidpprkrv dspmlnrhgk rrperksmev lsvtdggspv parraiemaq
      421 hgqskamfsk sldiaeahpq fskedrsrsi sgassglsts plssprpirk lvlpppppep
      481 pfvarplats tepeacgsas rpghvlplqa alrpdpktqt lpckakltdk plqgtksnpf
      541 pastparppa tglcpqlapp lgppalrvpp rpppagiepn tksvptiqvt phpsprgspl
      601 ptpkgtpvht pkespagtpn ptppsspsvg gvpwrarlns iknsflgspr fhrrklqvpt
      661 peemsnltpe sspelakksw fgnfisleke eqifvvikdk plssikadiv haflsipsls
      721 hsvisqtsfr aeykatggpa vfqkpvkfqv dityteggea qkengiysvt ftllsgpsrr
      781 fkrvvetiqa qllsthdppa aqhlsdttnc memmtgrlsk cgsplsnffd vikqlfsdek
      841 ngqaaqapst pakrsahgpl gdsaaagpgp ggdaeyptgk dtakmgppaa rreqp
//
LOCUS       XP_054226409             880 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase BRSK2 isoform X1 [Homo sapiens].
ACCESSION   XP_054226409
VERSION     XP_054226409.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370434.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 1% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..880
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..880
                     /product="serine/threonine-protein kinase BRSK2 isoform
                     X1"
                     /calculated_mol_wt=96579
     Region          17..270
                     /region_name="STKc_BRSK1_2"
                     /note="Catalytic domain of Brain-specific
                     serine/threonine-protein kinases 1 and 2; cd14081"
                     /db_xref="CDD:270983"
     Site            order(25..29,33,46,48,79,95..98,102,104..105,107,140..141,
                     143,145..146,148,158..159,162,176..180,182,212..215)
                     /site_type="active"
                     /db_xref="CDD:270983"
     Site            order(25..28,33,46,48,79,95..98,102,145..146,148,158..159)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270983"
     Site            order(102,104..105,107,141,143,145,162,176..180,182,
                     212..215)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270983"
     Site            order(158..169,171..180)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270983"
     Region          297..350
                     /region_name="UBA_BRSK"
                     /note="UBA domain found in serine/threonine-protein kinase
                     BRSK1, BRSK2 and similar proteins; cd14340"
                     /db_xref="CDD:270525"
     CDS             1..880
                     /gene="BRSK2"
                     /gene_synonym="C11orf7; PEN11B; SAD-A; SAD1; SADA; STK29"
                     /coded_by="XM_054370434.1:352..2994"
                     /db_xref="GeneID:9024"
                     /db_xref="HGNC:HGNC:11405"
                     /db_xref="MIM:609236"
ORIGIN      
        1 mtstgkdgga qhaqyvgpyr lektlgkgqt glvklgvhcv tcqkvaikiv nreklsesvl
       61 mkvereiail kliehphvlk lhdvyenkky lylvlehvsg gelfdylvkk grltpkeark
      121 ffrqiisald fchshsichr dlkpenllld eknniriadf gmaslqvgds lletscgsph
      181 yacpevirge kydgrkadvw scgvilfall vgalpfdddn lrqllekvkr gvfhmphfip
      241 pdcqsllrgm ievdaarrlt lehiqkhiwy iggknepepe qpiprkvqir slpsledidp
      301 dvldsmhslg cfrdrnkllq dllseeenqe kmiyfllldr kerypsqede dlpprneidp
      361 prkrvdspml nrhgkrrper ksmevlsvtd ggspvparra iemaqhgqsk amfsksldia
      421 eahpqfsked rsrsisgass glstsplssp rpirklvlpp pppeppfvar platstepea
      481 cgsasrpghv lplqaalrpd pktqtlpcka kltdkplqgt ksnpfpastp arppatglcp
      541 qlapplgppa lrvpprpppa giepntksvp tiqvtphpsp rgsplptpkg tpvhtpkesp
      601 agtpnptpps spsvggvpwr arlnsiknsf lgsprfhrrk lqvptpeems nltpesspel
      661 akkswfgnfi slekeeqifv vikdkplssi kadivhafls ipslshsvis qtsfraeyka
      721 tggpavfqkp vkfqvdityt eggeaqkeng iysvtftlls gpsrrfkrvv etiqaqllst
      781 hdppaaqhls dttncmemmt grlskcgspl snffdvikql fsdekngqaa qapstpakrs
      841 ahgplgdsaa agpgpggdae yptgkdtakm gppaarreqp
//
LOCUS       XP_054226410             879 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase BRSK2 isoform X28 [Homo sapiens].
ACCESSION   XP_054226410
VERSION     XP_054226410.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370435.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..879
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..879
                     /product="serine/threonine-protein kinase BRSK2 isoform
                     X28"
                     /calculated_mol_wt=96304
     Region          46..285
                     /region_name="STKc_BRSK1_2"
                     /note="Catalytic domain of Brain-specific
                     serine/threonine-protein kinases 1 and 2; cd14081"
                     /db_xref="CDD:270983"
     Site            order(48,61,63,94,110..113,117,119..120,122,155..156,158,
                     160..161,163,173..174,177,191..195,197,227..230)
                     /site_type="active"
                     /db_xref="CDD:270983"
     Site            order(117,119..120,122,156,158,160,177,191..195,197,
                     227..230)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270983"
     Site            order(173..184,186..195)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270983"
     Region          312..365
                     /region_name="UBA_BRSK"
                     /note="UBA domain found in serine/threonine-protein kinase
                     BRSK1, BRSK2 and similar proteins; cd14340"
                     /db_xref="CDD:270525"
     CDS             1..879
                     /gene="BRSK2"
                     /gene_synonym="C11orf7; PEN11B; SAD-A; SAD1; SADA; STK29"
                     /coded_by="XM_054370435.1:67..2706"
                     /db_xref="GeneID:9024"
                     /db_xref="HGNC:HGNC:11405"
                     /db_xref="MIM:609236"
ORIGIN      
        1 mragchvsvv ppqsfrnhrd gepagdtgfl sapaapkaeg ralraglvkl gvhcvtcqkv
       61 aikivnrekl sesvlmkver eiailklieh phvlklhdvy enkkylylvl ehvsggelfd
      121 ylvkkgrltp kearkffrqi isaldfchsh sichrdlkpe nllldeknni riadfgmasl
      181 qvgdsllets cgsphyacpe virgekydgr kadvwscgvi lfallvgalp fdddnlrqll
      241 ekvkrgvfhm phfippdcqs llrgmievda arrltlehiq khiwyiggkn epepeqpipr
      301 kvqirslpsl edidpdvlds mhslgcfrdr nkllqdllse eenqekmiyf llldrkeryp
      361 sqededlppr neidpprkrv dspmlnrhgk rrperksmev lsvtdggspv parraiemaq
      421 hgqskamfsk sldiaeahpq fskedrsrsi sgassglsts plssprpirk lvlpppppep
      481 pfvarplats tepeacgsas rpghvlplqa alrpdpktqt lpckakltdk plqgtksnpf
      541 pastparppa tglcpqlapp lgppalrvpp rpppagiepn tksvptiqvt phpsprgspl
      601 ptpkgtpvht pkespagtpn ptppsspsvg gvpwrarlns iknsflgspr fhrrklqvpt
      661 peemsnltpe sspelakksw fgnfisleke eqifvvikdk plssikadiv haflsipsls
      721 hsvisqtsfr aeykatggpa vfqkpvkfqv dityteggea qkengiysvt ftllsgpsrr
      781 fkrvvetiqa qllsthdppa aqhlsdttnc memmtgrlsk cdekngqaaq apstpakrsa
      841 hgplgdsaaa gpgpggdaey ptgkdtakmg ppaarreqp
//
LOCUS       XP_054226411             873 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase BRSK2 isoform X29 [Homo sapiens].
ACCESSION   XP_054226411
VERSION     XP_054226411.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370436.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..873
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..873
                     /product="serine/threonine-protein kinase BRSK2 isoform
                     X29"
                     /calculated_mol_wt=95636
     Region          46..285
                     /region_name="STKc_BRSK1_2"
                     /note="Catalytic domain of Brain-specific
                     serine/threonine-protein kinases 1 and 2; cd14081"
                     /db_xref="CDD:270983"
     Site            order(48,61,63,94,110..113,117,119..120,122,155..156,158,
                     160..161,163,173..174,177,191..195,197,227..230)
                     /site_type="active"
                     /db_xref="CDD:270983"
     Site            order(117,119..120,122,156,158,160,177,191..195,197,
                     227..230)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270983"
     Site            order(173..184,186..195)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270983"
     Region          312..365
                     /region_name="UBA_BRSK"
                     /note="UBA domain found in serine/threonine-protein kinase
                     BRSK1, BRSK2 and similar proteins; cd14340"
                     /db_xref="CDD:270525"
     CDS             1..873
                     /gene="BRSK2"
                     /gene_synonym="C11orf7; PEN11B; SAD-A; SAD1; SADA; STK29"
                     /coded_by="XM_054370436.1:67..2688"
                     /db_xref="GeneID:9024"
                     /db_xref="HGNC:HGNC:11405"
                     /db_xref="MIM:609236"
ORIGIN      
        1 mragchvsvv ppqsfrnhrd gepagdtgfl sapaapkaeg ralraglvkl gvhcvtcqkv
       61 aikivnrekl sesvlmkver eiailklieh phvlklhdvy enkkylylvl ehvsggelfd
      121 ylvkkgrltp kearkffrqi isaldfchsh sichrdlkpe nllldeknni riadfgmasl
      181 qvgdsllets cgsphyacpe virgekydgr kadvwscgvi lfallvgalp fdddnlrqll
      241 ekvkrgvfhm phfippdcqs llrgmievda arrltlehiq khiwyiggkn epepeqpipr
      301 kvqirslpsl edidpdvlds mhslgcfrdr nkllqdllse eenqekmiyf llldrkeryp
      361 sqededlppr neidpprkrv dspmlnrhgk rrperksmev lsvtdggspv parraiemaq
      421 hgqrsrsisg assglstspl ssprpirklv lpppppeppf varplatste peacgsasrp
      481 ghvlplqaal rpdpktqtlp ckakltdkpl qgtksnpfpa stparppatg lcpqlapplg
      541 ppalrvpprp ppagiepntk svptiqvtph psprgsplpt pkgtpvhtpk espagtpnpt
      601 ppsspsvggv pwrarlnsik nsflgsprfh rrklqvptpe emsnltpess pelakkswfg
      661 nfislekeeq ifvvikdkpl ssikadivha flsipslshs visqtsfrae ykatggpavf
      721 qkpvkfqvdi tyteggeaqk engiysvtft llsgpsrrfk rvvetiqaql lsthdppaaq
      781 hlsdttncme mmtgrlskcg splsnffdvi kqlfsdekng qaaqapstpa krsahgplgd
      841 saaagpgpgg daeyptgkdt akmgppaarr eqp
//
LOCUS       XP_054226412             858 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase BRSK2 isoform X2 [Homo sapiens].
ACCESSION   XP_054226412
VERSION     XP_054226412.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370437.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 11% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..858
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..858
                     /product="serine/threonine-protein kinase BRSK2 isoform
                     X2"
                     /calculated_mol_wt=94130
     Region          17..270
                     /region_name="STKc_BRSK1_2"
                     /note="Catalytic domain of Brain-specific
                     serine/threonine-protein kinases 1 and 2; cd14081"
                     /db_xref="CDD:270983"
     Site            order(25..29,33,46,48,79,95..98,102,104..105,107,140..141,
                     143,145..146,148,158..159,162,176..180,182,212..215)
                     /site_type="active"
                     /db_xref="CDD:270983"
     Site            order(25..28,33,46,48,79,95..98,102,145..146,148,158..159)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270983"
     Site            order(102,104..105,107,141,143,145,162,176..180,182,
                     212..215)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270983"
     Site            order(158..169,171..180)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270983"
     Region          297..350
                     /region_name="UBA_BRSK"
                     /note="UBA domain found in serine/threonine-protein kinase
                     BRSK1, BRSK2 and similar proteins; cd14340"
                     /db_xref="CDD:270525"
     CDS             1..858
                     /gene="BRSK2"
                     /gene_synonym="C11orf7; PEN11B; SAD-A; SAD1; SADA; STK29"
                     /coded_by="XM_054370437.1:352..2928"
                     /db_xref="GeneID:9024"
                     /db_xref="HGNC:HGNC:11405"
                     /db_xref="MIM:609236"
ORIGIN      
        1 mtstgkdgga qhaqyvgpyr lektlgkgqt glvklgvhcv tcqkvaikiv nreklsesvl
       61 mkvereiail kliehphvlk lhdvyenkky lylvlehvsg gelfdylvkk grltpkeark
      121 ffrqiisald fchshsichr dlkpenllld eknniriadf gmaslqvgds lletscgsph
      181 yacpevirge kydgrkadvw scgvilfall vgalpfdddn lrqllekvkr gvfhmphfip
      241 pdcqsllrgm ievdaarrlt lehiqkhiwy iggknepepe qpiprkvqir slpsledidp
      301 dvldsmhslg cfrdrnkllq dllseeenqe kmiyfllldr kerypsqede dlpprneidp
      361 prkrvdspml nrhgkrrper ksmevlsvtd ggspvparra iemaqhgqrs rsisgassgl
      421 stsplssprp irklvlpppp peppfvarpl atstepeacg sasrpghvlp lqaalrpdpk
      481 tqtlpckakl tdkplqgtks npfpastpar ppatglcpql applgppalr vpprpppagi
      541 epntksvpti qvtphpsprg splptpkgtp vhtpkespag tpnptppssp svggvpwrar
      601 lnsiknsflg sprfhrrklq vptpeemsnl tpesspelak kswfgnfisl ekeeqifvvi
      661 kdkplssika divhaflsip slshsvisqt sfraeykatg gpavfqkpvk fqvdityteg
      721 geaqkengiy svtftllsgp srrfkrvvet iqaqllsthd ppaaqhlsdt tncmemmtgr
      781 lskcgsplsn ffdvikqlfs dekngqaaqa pstpakrsah gplgdsaaag pgpggdaeyp
      841 tgkdtakmgp paarreqp
//
LOCUS       XP_054226413             827 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase BRSK2 isoform X30 [Homo sapiens].
ACCESSION   XP_054226413
VERSION     XP_054226413.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370438.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..827
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..827
                     /product="serine/threonine-protein kinase BRSK2 isoform
                     X30"
                     /calculated_mol_wt=91222
     Region          46..285
                     /region_name="STKc_BRSK1_2"
                     /note="Catalytic domain of Brain-specific
                     serine/threonine-protein kinases 1 and 2; cd14081"
                     /db_xref="CDD:270983"
     Site            order(48,61,63,94,110..113,117,119..120,122,155..156,158,
                     160..161,163,173..174,177,191..195,197,227..230)
                     /site_type="active"
                     /db_xref="CDD:270983"
     Site            order(117,119..120,122,156,158,160,177,191..195,197,
                     227..230)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270983"
     Site            order(173..184,186..195)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270983"
     Region          312..365
                     /region_name="UBA_BRSK"
                     /note="UBA domain found in serine/threonine-protein kinase
                     BRSK1, BRSK2 and similar proteins; cd14340"
                     /db_xref="CDD:270525"
     CDS             1..827
                     /gene="BRSK2"
                     /gene_synonym="C11orf7; PEN11B; SAD-A; SAD1; SADA; STK29"
                     /coded_by="XM_054370438.1:65..2548"
                     /db_xref="GeneID:9024"
                     /db_xref="HGNC:HGNC:11405"
                     /db_xref="MIM:609236"
ORIGIN      
        1 mragchvsvv ppqsfrnhrd gepagdtgfl sapaapkaeg ralraglvkl gvhcvtcqkv
       61 aikivnrekl sesvlmkver eiailklieh phvlklhdvy enkkylylvl ehvsggelfd
      121 ylvkkgrltp kearkffrqi isaldfchsh sichrdlkpe nllldeknni riadfgmasl
      181 qvgdsllets cgsphyacpe virgekydgr kadvwscgvi lfallvgalp fdddnlrqll
      241 ekvkrgvfhm phfippdcqs llrgmievda arrltlehiq khiwyiggkn epepeqpipr
      301 kvqirslpsl edidpdvlds mhslgcfrdr nkllqdllse eenqekmiyf llldrkeryp
      361 sqededlppr neidpprkrv dspmlnrhgk rrperksmev lsvtdggspv parraiemaq
      421 hgqskamfsk sldiaeahpq fskedrsrsi sgassglsts plssprpirk lvlpppppep
      481 pfvarplats tepeacgsas rpghvlplqa alrpdpktqt lpckakltdk plqgtksnpf
      541 pastparppa tglcpqlapp lgppalrvpp rpppagiepn tksvptiqvt phpsprgspl
      601 ptpkgtpvht pkespagtpn ptppsspsvg gvpwrarlns iknsflgspr fhrrklqvpt
      661 peemsnltpe sspelakksw fgnfisleke eqifvvikdk plssikadiv haflsipsls
      721 hsvisqtsfr aeykatggpa vfqkpvkfqv dityteggea qkengiysvt ftllsgpsrr
      781 fkrvvetiqa qllsthdppa aqhlsdttnc memmtgrlsk cgiipks
//
LOCUS       XP_054226416             773 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase BRSK2 isoform X31 [Homo sapiens].
ACCESSION   XP_054226416
VERSION     XP_054226416.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370441.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..773
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..773
                     /product="serine/threonine-protein kinase BRSK2 isoform
                     X31"
                     /calculated_mol_wt=85427
     Region          46..285
                     /region_name="STKc_BRSK1_2"
                     /note="Catalytic domain of Brain-specific
                     serine/threonine-protein kinases 1 and 2; cd14081"
                     /db_xref="CDD:270983"
     Site            order(48,61,63,94,110..113,117,119..120,122,155..156,158,
                     160..161,163,173..174,177,191..195,197,227..230)
                     /site_type="active"
                     /db_xref="CDD:270983"
     Site            order(117,119..120,122,156,158,160,177,191..195,197,
                     227..230)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270983"
     Site            order(173..184,186..195)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270983"
     Region          312..365
                     /region_name="UBA_BRSK"
                     /note="UBA domain found in serine/threonine-protein kinase
                     BRSK1, BRSK2 and similar proteins; cd14340"
                     /db_xref="CDD:270525"
     CDS             1..773
                     /gene="BRSK2"
                     /gene_synonym="C11orf7; PEN11B; SAD-A; SAD1; SADA; STK29"
                     /coded_by="XM_054370441.1:63..2384"
                     /db_xref="GeneID:9024"
                     /db_xref="HGNC:HGNC:11405"
                     /db_xref="MIM:609236"
ORIGIN      
        1 mragchvsvv ppqsfrnhrd gepagdtgfl sapaapkaeg ralraglvkl gvhcvtcqkv
       61 aikivnrekl sesvlmkver eiailklieh phvlklhdvy enkkylylvl ehvsggelfd
      121 ylvkkgrltp kearkffrqi isaldfchsh sichrdlkpe nllldeknni riadfgmasl
      181 qvgdsllets cgsphyacpe virgekydgr kadvwscgvi lfallvgalp fdddnlrqll
      241 ekvkrgvfhm phfippdcqs llrgmievda arrltlehiq khiwyiggkn epepeqpipr
      301 kvqirslpsl edidpdvlds mhslgcfrdr nkllqdllse eenqekmiyf llldrkeryp
      361 sqededlppr neidpprkrv dspmlnrhgk rrperksmev lsvtdggspv parraiemaq
      421 hgqskamfsk sldiaeahpq fskedrsrsi sgassglsts plssprvtph psprgsplpt
      481 pkgtpvhtpk espagtpnpt ppsspsvggv pwrarlnsik nsflgsprfh rrklqvptpe
      541 emsnltpess pelakkswfg nfislekeeq ifvvikdkpl ssikadivha flsipslshs
      601 visqtsfrae ykatggpavf qkpvkfqvdi tyteggeaqk engiysvtft llsgpsrrfk
      661 rvvetiqaql lsthdppaaq hlsdttncme mmtgrlskcg splsnffdvi kqlfsdekng
      721 qaaqapstpa krsahgplgd saaagpgpgg daeyptgkdt akmgppaarr eqp
//
LOCUS       XP_054226417             758 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase BRSK2 isoform X5 [Homo sapiens].
ACCESSION   XP_054226417
VERSION     XP_054226417.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370442.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 12% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..758
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..758
                     /product="serine/threonine-protein kinase BRSK2 isoform
                     X5"
                     /calculated_mol_wt=83921
     Region          17..270
                     /region_name="STKc_BRSK1_2"
                     /note="Catalytic domain of Brain-specific
                     serine/threonine-protein kinases 1 and 2; cd14081"
                     /db_xref="CDD:270983"
     Site            order(25..29,33,46,48,79,95..98,102,104..105,107,140..141,
                     143,145..146,148,158..159,162,176..180,182,212..215)
                     /site_type="active"
                     /db_xref="CDD:270983"
     Site            order(25..28,33,46,48,79,95..98,102,145..146,148,158..159)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270983"
     Site            order(102,104..105,107,141,143,145,162,176..180,182,
                     212..215)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270983"
     Site            order(158..169,171..180)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270983"
     Region          297..350
                     /region_name="UBA_BRSK"
                     /note="UBA domain found in serine/threonine-protein kinase
                     BRSK1, BRSK2 and similar proteins; cd14340"
                     /db_xref="CDD:270525"
     CDS             1..758
                     /gene="BRSK2"
                     /gene_synonym="C11orf7; PEN11B; SAD-A; SAD1; SADA; STK29"
                     /coded_by="XM_054370442.1:352..2628"
                     /db_xref="GeneID:9024"
                     /db_xref="HGNC:HGNC:11405"
                     /db_xref="MIM:609236"
ORIGIN      
        1 mtstgkdgga qhaqyvgpyr lektlgkgqt glvklgvhcv tcqkvaikiv nreklsesvl
       61 mkvereiail kliehphvlk lhdvyenkky lylvlehvsg gelfdylvkk grltpkeark
      121 ffrqiisald fchshsichr dlkpenllld eknniriadf gmaslqvgds lletscgsph
      181 yacpevirge kydgrkadvw scgvilfall vgalpfdddn lrqllekvkr gvfhmphfip
      241 pdcqsllrgm ievdaarrlt lehiqkhiwy iggknepepe qpiprkvqir slpsledidp
      301 dvldsmhslg cfrdrnkllq dllseeenqe kmiyfllldr kerypsqede dlpprneidp
      361 prkrvdspml nrhgkrrper ksmevlsvtd ggspvparra iemaqhgqsk amfsksldia
      421 eahpqfsked rsrsisgass glstsplssp rvtphpsprg splptpkgtp vhtpkespag
      481 tpnptppssp svggvpwrar lnsiknsflg sprfhrrklq vptpeemsnl tpesspelak
      541 kswfgnfisl ekeeqifvvi kdkplssika divhaflsip slshsvisqt sfraeykatg
      601 gpavfqkpvk fqvdityteg geaqkengiy svtftllsgp srrfkrvvet iqaqllsthd
      661 ppaaqhlsdt tncmemmtgr lskcgsplsn ffdvikqlfs dekngqaaqa pstpakrsah
      721 gplgdsaaag pgpggdaeyp tgkdtakmgp paarreqp
//
LOCUS       XP_054226418             757 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase BRSK2 isoform X32 [Homo sapiens].
ACCESSION   XP_054226418
VERSION     XP_054226418.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370443.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..757
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..757
                     /product="serine/threonine-protein kinase BRSK2 isoform
                     X32"
                     /calculated_mol_wt=83646
     Region          46..285
                     /region_name="STKc_BRSK1_2"
                     /note="Catalytic domain of Brain-specific
                     serine/threonine-protein kinases 1 and 2; cd14081"
                     /db_xref="CDD:270983"
     Site            order(48,61,63,94,110..113,117,119..120,122,155..156,158,
                     160..161,163,173..174,177,191..195,197,227..230)
                     /site_type="active"
                     /db_xref="CDD:270983"
     Site            order(117,119..120,122,156,158,160,177,191..195,197,
                     227..230)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270983"
     Site            order(173..184,186..195)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270983"
     Region          312..365
                     /region_name="UBA_BRSK"
                     /note="UBA domain found in serine/threonine-protein kinase
                     BRSK1, BRSK2 and similar proteins; cd14340"
                     /db_xref="CDD:270525"
     CDS             1..757
                     /gene="BRSK2"
                     /gene_synonym="C11orf7; PEN11B; SAD-A; SAD1; SADA; STK29"
                     /coded_by="XM_054370443.1:63..2336"
                     /db_xref="GeneID:9024"
                     /db_xref="HGNC:HGNC:11405"
                     /db_xref="MIM:609236"
ORIGIN      
        1 mragchvsvv ppqsfrnhrd gepagdtgfl sapaapkaeg ralraglvkl gvhcvtcqkv
       61 aikivnrekl sesvlmkver eiailklieh phvlklhdvy enkkylylvl ehvsggelfd
      121 ylvkkgrltp kearkffrqi isaldfchsh sichrdlkpe nllldeknni riadfgmasl
      181 qvgdsllets cgsphyacpe virgekydgr kadvwscgvi lfallvgalp fdddnlrqll
      241 ekvkrgvfhm phfippdcqs llrgmievda arrltlehiq khiwyiggkn epepeqpipr
      301 kvqirslpsl edidpdvlds mhslgcfrdr nkllqdllse eenqekmiyf llldrkeryp
      361 sqededlppr neidpprkrv dspmlnrhgk rrperksmev lsvtdggspv parraiemaq
      421 hgqskamfsk sldiaeahpq fskedrsrsi sgassglsts plssprvtph psprgsplpt
      481 pkgtpvhtpk espagtpnpt ppsspsvggv pwrarlnsik nsflgsprfh rrklqvptpe
      541 emsnltpess pelakkswfg nfislekeeq ifvvikdkpl ssikadivha flsipslshs
      601 visqtsfrae ykatggpavf qkpvkfqvdi tyteggeaqk engiysvtft llsgpsrrfk
      661 rvvetiqaql lsthdppaaq hlsdttncme mmtgrlskcd ekngqaaqap stpakrsahg
      721 plgdsaaagp gpggdaeypt gkdtakmgpp aarreqp
//
LOCUS       XP_054226420             735 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase BRSK2 isoform X34 [Homo sapiens].
ACCESSION   XP_054226420
VERSION     XP_054226420.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370445.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..735
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..735
                     /product="serine/threonine-protein kinase BRSK2 isoform
                     X34"
                     /calculated_mol_wt=81197
     Region          46..285
                     /region_name="STKc_BRSK1_2"
                     /note="Catalytic domain of Brain-specific
                     serine/threonine-protein kinases 1 and 2; cd14081"
                     /db_xref="CDD:270983"
     Site            order(48,61,63,94,110..113,117,119..120,122,155..156,158,
                     160..161,163,173..174,177,191..195,197,227..230)
                     /site_type="active"
                     /db_xref="CDD:270983"
     Site            order(117,119..120,122,156,158,160,177,191..195,197,
                     227..230)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270983"
     Site            order(173..184,186..195)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270983"
     Region          312..365
                     /region_name="UBA_BRSK"
                     /note="UBA domain found in serine/threonine-protein kinase
                     BRSK1, BRSK2 and similar proteins; cd14340"
                     /db_xref="CDD:270525"
     CDS             1..735
                     /gene="BRSK2"
                     /gene_synonym="C11orf7; PEN11B; SAD-A; SAD1; SADA; STK29"
                     /coded_by="XM_054370445.1:62..2269"
                     /db_xref="GeneID:9024"
                     /db_xref="HGNC:HGNC:11405"
                     /db_xref="MIM:609236"
ORIGIN      
        1 mragchvsvv ppqsfrnhrd gepagdtgfl sapaapkaeg ralraglvkl gvhcvtcqkv
       61 aikivnrekl sesvlmkver eiailklieh phvlklhdvy enkkylylvl ehvsggelfd
      121 ylvkkgrltp kearkffrqi isaldfchsh sichrdlkpe nllldeknni riadfgmasl
      181 qvgdsllets cgsphyacpe virgekydgr kadvwscgvi lfallvgalp fdddnlrqll
      241 ekvkrgvfhm phfippdcqs llrgmievda arrltlehiq khiwyiggkn epepeqpipr
      301 kvqirslpsl edidpdvlds mhslgcfrdr nkllqdllse eenqekmiyf llldrkeryp
      361 sqededlppr neidpprkrv dspmlnrhgk rrperksmev lsvtdggspv parraiemaq
      421 hgqrsrsisg assglstspl ssprvtphps prgsplptpk gtpvhtpkes pagtpnptpp
      481 sspsvggvpw rarlnsikns flgsprfhrr klqvptpeem snltpesspe lakkswfgnf
      541 islekeeqif vvikdkplss ikadivhafl sipslshsvi sqtsfraeyk atggpavfqk
      601 pvkfqvdity teggeaqken giysvtftll sgpsrrfkrv vetiqaqlls thdppaaqhl
      661 sdttncmemm tgrlskcdek ngqaaqapst pakrsahgpl gdsaaagpgp ggdaeyptgk
      721 dtakmgppaa rreqp
//
LOCUS       XP_054226421             720 aa            linear   PRI 05-AUG-2025
DEFINITION  serine/threonine-protein kinase BRSK2 isoform X6 [Homo sapiens].
ACCESSION   XP_054226421
VERSION     XP_054226421.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370446.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 13% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..720
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..720
                     /product="serine/threonine-protein kinase BRSK2 isoform
                     X6"
                     /calculated_mol_wt=79691
     Region          17..270
                     /region_name="STKc_BRSK1_2"
                     /note="Catalytic domain of Brain-specific
                     serine/threonine-protein kinases 1 and 2; cd14081"
                     /db_xref="CDD:270983"
     Site            order(25..29,33,46,48,79,95..98,102,104..105,107,140..141,
                     143,145..146,148,158..159,162,176..180,182,212..215)
                     /site_type="active"
                     /db_xref="CDD:270983"
     Site            order(25..28,33,46,48,79,95..98,102,145..146,148,158..159)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270983"
     Site            order(102,104..105,107,141,143,145,162,176..180,182,
                     212..215)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270983"
     Site            order(158..169,171..180)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270983"
     Region          297..350
                     /region_name="UBA_BRSK"
                     /note="UBA domain found in serine/threonine-protein kinase
                     BRSK1, BRSK2 and similar proteins; cd14340"
                     /db_xref="CDD:270525"
     CDS             1..720
                     /gene="BRSK2"
                     /gene_synonym="C11orf7; PEN11B; SAD-A; SAD1; SADA; STK29"
                     /coded_by="XM_054370446.1:352..2514"
                     /db_xref="GeneID:9024"
                     /db_xref="HGNC:HGNC:11405"
                     /db_xref="MIM:609236"
ORIGIN      
        1 mtstgkdgga qhaqyvgpyr lektlgkgqt glvklgvhcv tcqkvaikiv nreklsesvl
       61 mkvereiail kliehphvlk lhdvyenkky lylvlehvsg gelfdylvkk grltpkeark
      121 ffrqiisald fchshsichr dlkpenllld eknniriadf gmaslqvgds lletscgsph
      181 yacpevirge kydgrkadvw scgvilfall vgalpfdddn lrqllekvkr gvfhmphfip
      241 pdcqsllrgm ievdaarrlt lehiqkhiwy iggknepepe qpiprkvqir slpsledidp
      301 dvldsmhslg cfrdrnkllq dllseeenqe kmiyfllldr kerypsqede dlpprneidp
      361 prkrvdspml nrhgkrrper ksmevlsvtd ggspvparra iemaqhgqrs rsisgassgl
      421 stsplssprv tphpsprgsp lptpkgtpvh tpkespagtp nptppsspsv ggvpwrarln
      481 siknsflgsp rfhrrklqvp tpeemsnltp esspelakks wfgnfislek eeqifvvikd
      541 kplssikadi vhaflsipsl shsvisqtsf raeykatggp avfqkpvkfq vditytegge
      601 aqkengiysv tftllsgpsr rfkrvvetiq aqllsthdpp aaqhlsdttn cmemmtgrls
      661 kcdekngqaa qapstpakrs ahgplgdsaa agpgpggdae yptgkdtakm gppaarreqp
//
LOCUS       XP_054226424             330 aa            linear   PRI 05-AUG-2025
DEFINITION  AH receptor-interacting protein isoform X1 [Homo sapiens].
ACCESSION   XP_054226424
VERSION     XP_054226424.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370449.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..330
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..330
                     /product="AH receptor-interacting protein isoform X1"
                     /calculated_mol_wt=37533
     Region          29..>90
                     /region_name="FKBP_C"
                     /note="FKBP-type peptidyl-prolyl cis-trans isomerase;
                     cl19519"
                     /db_xref="CDD:473184"
     Site            order(183..184,187..188,190,232,235..236,239..240,
                     242..243,266,269..270,273..274,277)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          183..225
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          186..>309
                     /region_name="Spy"
                     /note="Predicted O-linked N-acetylglucosamine transferase,
                     SPINDLY family [Posttranslational modification, protein
                     turnover, chaperones]; COG3914"
                     /db_xref="CDD:443119"
     Region          230..260
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          265..293
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..330
                     /gene="AIP"
                     /gene_synonym="ARA9; FKBP16; FKBP37; PITA1; SMTPHN; XAP-2;
                     XAP2"
                     /coded_by="XM_054370449.1:450..1442"
                     /db_xref="GeneID:9049"
                     /db_xref="HGNC:HGNC:358"
                     /db_xref="MIM:605555"
ORIGIN      
        1 madiiarlre dgiqkrviqe grgelpdfqd gtkatfhyrt lhsddegtvl ddsrargkpm
       61 eliigkkfkl pvwetivctm regeiaqflc dikhvvlypl vakslrniav gkdplegqrh
      121 ccgvaqmreh sslghadlda lqqnpqplif hmemlkvesp gtyqqdpwam tdeekakavp
      181 lihqegnrly reghvkeaaa kyydaiaclk nlqmkeqpgs pewiqldkqi tplllnycqc
      241 klvveeyyev ldhcssilnk yddnvkayfk rgkahaavwn aqeaqadfak vleldpalap
      301 vvsrelrale arirqkdeed karfrgifsh
//
LOCUS       XP_054226425             692 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-7 isoform X1 [Homo sapiens].
ACCESSION   XP_054226425
VERSION     XP_054226425.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370450.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..692
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..692
                     /product="synaptotagmin-7 isoform X1"
                     /calculated_mol_wt=76308
     Region          <149..>316
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          424..548
                     /region_name="C2A_Synaptotagmin-7"
                     /note="C2A domain first repeat present in Synaptotagmin 7;
                     cd08386"
                     /db_xref="CDD:176032"
     Site            order(455,461,514,516,522)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:176032"
     Region          556..691
                     /region_name="C2B_Synaptotagmin-7"
                     /note="C2 domain second repeat present in Synaptotagmin 7;
                     cd08405"
                     /db_xref="CDD:176050"
     Site            order(586,592,646,648)
                     /site_type="other"
                     /note="Ca2+ binding pocket [ion binding]"
                     /db_xref="CDD:176050"
     CDS             1..692
                     /gene="SYT7"
                     /gene_synonym="IPCA-7; IPCA7; PCANAP7; SYT-VII; SYTVII"
                     /coded_by="XM_054370450.1:33..2111"
                     /db_xref="GeneID:9066"
                     /db_xref="HGNC:HGNC:11514"
                     /db_xref="MIM:604146"
ORIGIN      
        1 mrvmhlapgp gspselraps rdvllvsaii tvslsvtvvl cglchwcqrk lgkryknsle
       61 tvgtpdsgrg rsekkaindl drdfwnnnes tvqqkwssyp pkefilnisp yapygdprls
      121 lngtllsgak vaaaaglave regrlgekpa pvpppgedal rsggaapsep gsggkagrgr
      181 wrtvqshlaa gklnlsnfed stlstattle sipsstgepk cqrprtlmrq qslqqplsqh
      241 qrgrqpsqpt tsqslgqlqa hmasapgpnp raygrgqarq gtsagskyra aggrsrsnpg
      301 swdhvvgqir nrgldmksfl egrmvvlslv lglseqddfa nipdlqnpgt qqnqnaqgdk
      361 rlpaggkavn tapvpgqtph desdrrtepr ssvsdlvnsl tsemlmlspg seedeahegc
      421 srenlgriqf svgynfqest ltvkimkaqe lpakdfsgts dpfvkiyllp dkkhkletkv
      481 krknlnphwn etflfegfpy ekvvqrilyl qvldydrfsr ndpigevsip lnkvdltqmq
      541 tfwkdlkpcs dgsgsrgell lslcynpsan siivniikar nlkamdiggt sdpyvkvwlm
      601 ykdkrvekkk tvtmkrnlnp ifnesfafdi pteklretti iitvmdkdkl srndvigkiy
      661 lswksgpgev khwkdmiarp rqpvaqwhql ka
//
LOCUS       XP_054226426             651 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-7 isoform X2 [Homo sapiens].
ACCESSION   XP_054226426
VERSION     XP_054226426.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370451.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..651
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..651
                     /product="synaptotagmin-7 isoform X2"
                     /calculated_mol_wt=71829
     Region          <149..>316
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          383..507
                     /region_name="C2A_Synaptotagmin-7"
                     /note="C2A domain first repeat present in Synaptotagmin 7;
                     cd08386"
                     /db_xref="CDD:176032"
     Site            order(414,420,473,475,481)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:176032"
     Region          515..650
                     /region_name="C2B_Synaptotagmin-7"
                     /note="C2 domain second repeat present in Synaptotagmin 7;
                     cd08405"
                     /db_xref="CDD:176050"
     Site            order(545,551,605,607)
                     /site_type="other"
                     /note="Ca2+ binding pocket [ion binding]"
                     /db_xref="CDD:176050"
     CDS             1..651
                     /gene="SYT7"
                     /gene_synonym="IPCA-7; IPCA7; PCANAP7; SYT-VII; SYTVII"
                     /coded_by="XM_054370451.1:31..1986"
                     /db_xref="GeneID:9066"
                     /db_xref="HGNC:HGNC:11514"
                     /db_xref="MIM:604146"
ORIGIN      
        1 mrvmhlapgp gspselraps rdvllvsaii tvslsvtvvl cglchwcqrk lgkryknsle
       61 tvgtpdsgrg rsekkaindl drdfwnnnes tvqqkwssyp pkefilnisp yapygdprls
      121 lngtllsgak vaaaaglave regrlgekpa pvpppgedal rsggaapsep gsggkagrgr
      181 wrtvqshlaa gklnlsnfed stlstattle sipsstgepk cqrprtlmrq qslqqplsqh
      241 qrgrqpsqpt tsqslgqlqa hmasapgpnp raygrgqarq gtsagskyra aggrsrsnpg
      301 swdhvvgqir nrgldmksfl lpaggkavnt apvpgqtphd esdrrteprs svsdlvnslt
      361 semlmlspgs eedeahegcs renlgriqfs vgynfqestl tvkimkaqel pakdfsgtsd
      421 pfvkiyllpd kkhkletkvk rknlnphwne tflfegfpye kvvqrilylq vldydrfsrn
      481 dpigevsipl nkvdltqmqt fwkdlkpcsd gsgsrgelll slcynpsans iivniikarn
      541 lkamdiggts dpyvkvwlmy kdkrvekkkt vtmkrnlnpi fnesfafdip teklrettii
      601 itvmdkdkls rndvigkiyl swksgpgevk hwkdmiarpr qpvaqwhqlk a
//
LOCUS       XP_054226427             648 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-7 isoform X3 [Homo sapiens].
ACCESSION   XP_054226427
VERSION     XP_054226427.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370452.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..648
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..648
                     /product="synaptotagmin-7 isoform X3"
                     /calculated_mol_wt=71109
     Region          <105..>272
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          380..504
                     /region_name="C2A_Synaptotagmin-7"
                     /note="C2A domain first repeat present in Synaptotagmin 7;
                     cd08386"
                     /db_xref="CDD:176032"
     Site            order(411,417,470,472,478)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:176032"
     Region          512..647
                     /region_name="C2B_Synaptotagmin-7"
                     /note="C2 domain second repeat present in Synaptotagmin 7;
                     cd08405"
                     /db_xref="CDD:176050"
     Site            order(542,548,602,604)
                     /site_type="other"
                     /note="Ca2+ binding pocket [ion binding]"
                     /db_xref="CDD:176050"
     CDS             1..648
                     /gene="SYT7"
                     /gene_synonym="IPCA-7; IPCA7; PCANAP7; SYT-VII; SYTVII"
                     /coded_by="XM_054370452.1:32..1978"
                     /db_xref="GeneID:9066"
                     /db_xref="HGNC:HGNC:11514"
                     /db_xref="MIM:604146"
ORIGIN      
        1 mrvmhlapgp gspselraps rdvllvsaii tvslsvtvvl cglchwcqrk lgkryknsle
       61 tvgtpdsgrg rsekkaingt llsgakvaaa aglaveregr lgekpapvpp pgedalrsgg
      121 aapsepgsgg kagrgrwrtv qshlaagkln lsnfedstls tattlesips stgepkcqrp
      181 rtlmrqqslq qplsqhqrgr qpsqpttsqs lgqlqahmas apgpnprayg rgqarqgtsa
      241 gskyraaggr srsnpgswdh vvgqirnrgl dmksflegrm vvlslvlgls eqddfanipd
      301 lqnpgtqqnq naqgdkrlpa ggkavntapv pgqtphdesd rrteprssvs dlvnsltsem
      361 lmlspgseed eahegcsren lgriqfsvgy nfqestltvk imkaqelpak dfsgtsdpfv
      421 kiyllpdkkh kletkvkrkn lnphwnetfl fegfpyekvv qrilylqvld ydrfsrndpi
      481 gevsiplnkv dltqmqtfwk dlkpcsdgsg srgelllslc ynpsansiiv niikarnlka
      541 mdiggtsdpy vkvwlmykdk rvekkktvtm krnlnpifne sfafdiptek lrettiiitv
      601 mdkdklsrnd vigkiylswk sgpgevkhwk dmiarprqpv aqwhqlka
//
LOCUS       XP_054226428             642 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-7 isoform X4 [Homo sapiens].
ACCESSION   XP_054226428
VERSION     XP_054226428.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370453.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..642
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..642
                     /product="synaptotagmin-7 isoform X4"
                     /calculated_mol_wt=70467
     Region          <99..>266
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          374..498
                     /region_name="C2A_Synaptotagmin-7"
                     /note="C2A domain first repeat present in Synaptotagmin 7;
                     cd08386"
                     /db_xref="CDD:176032"
     Site            order(405,411,464,466,472)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:176032"
     Region          506..641
                     /region_name="C2B_Synaptotagmin-7"
                     /note="C2 domain second repeat present in Synaptotagmin 7;
                     cd08405"
                     /db_xref="CDD:176050"
     Site            order(536,542,596,598)
                     /site_type="other"
                     /note="Ca2+ binding pocket [ion binding]"
                     /db_xref="CDD:176050"
     CDS             1..642
                     /gene="SYT7"
                     /gene_synonym="IPCA-7; IPCA7; PCANAP7; SYT-VII; SYTVII"
                     /coded_by="XM_054370453.1:257..2185"
                     /db_xref="GeneID:9066"
                     /db_xref="HGNC:HGNC:11514"
                     /db_xref="MIM:604146"
ORIGIN      
        1 myrdpeaasp gapsrdvllv saiitvslsv tvvlcglchw cqrklgkryk nsletvgtpd
       61 sgrgrsekka ingtllsgak vaaaaglave regrlgekpa pvpppgedal rsggaapsep
      121 gsggkagrgr wrtvqshlaa gklnlsnfed stlstattle sipsstgepk cqrprtlmrq
      181 qslqqplsqh qrgrqpsqpt tsqslgqlqa hmasapgpnp raygrgqarq gtsagskyra
      241 aggrsrsnpg swdhvvgqir nrgldmksfl egrmvvlslv lglseqddfa nipdlqnpgt
      301 qqnqnaqgdk rlpaggkavn tapvpgqtph desdrrtepr ssvsdlvnsl tsemlmlspg
      361 seedeahegc srenlgriqf svgynfqest ltvkimkaqe lpakdfsgts dpfvkiyllp
      421 dkkhkletkv krknlnphwn etflfegfpy ekvvqrilyl qvldydrfsr ndpigevsip
      481 lnkvdltqmq tfwkdlkpcs dgsgsrgell lslcynpsan siivniikar nlkamdiggt
      541 sdpyvkvwlm ykdkrvekkk tvtmkrnlnp ifnesfafdi pteklretti iitvmdkdkl
      601 srndvigkiy lswksgpgev khwkdmiarp rqpvaqwhql ka
//
LOCUS       XP_054226429             617 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-7 isoform X5 [Homo sapiens].
ACCESSION   XP_054226429
VERSION     XP_054226429.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370454.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..617
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..617
                     /product="synaptotagmin-7 isoform X5"
                     /calculated_mol_wt=68989
     Region          349..473
                     /region_name="C2A_Synaptotagmin-7"
                     /note="C2A domain first repeat present in Synaptotagmin 7;
                     cd08386"
                     /db_xref="CDD:176032"
     Site            order(380,386,439,441,447)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:176032"
     Region          481..616
                     /region_name="C2B_Synaptotagmin-7"
                     /note="C2 domain second repeat present in Synaptotagmin 7;
                     cd08405"
                     /db_xref="CDD:176050"
     Site            order(511,517,571,573)
                     /site_type="other"
                     /note="Ca2+ binding pocket [ion binding]"
                     /db_xref="CDD:176050"
     CDS             1..617
                     /gene="SYT7"
                     /gene_synonym="IPCA-7; IPCA7; PCANAP7; SYT-VII; SYTVII"
                     /coded_by="XM_054370454.1:30..1883"
                     /db_xref="GeneID:9066"
                     /db_xref="HGNC:HGNC:11514"
                     /db_xref="MIM:604146"
ORIGIN      
        1 mrvmhlapgp gspselraps rdvllvsaii tvslsvtvvl cglchwcqrk lgkryknsle
       61 tvgtpdsgrg rsekkaindl drdfwnnnes tvqqkwssyp pkefilnisp yapygdprls
      121 lnfedstlst attlesipss tgepkcqrpr tlmrqqslqq plsqhqrgrq psqpttsqsl
      181 gqlqahmasa pgpnpraygr gqarqgtsag skyraaggrs rsnpgswdhv vgqirnrgld
      241 mksflegrmv vlslvlglse qddfanipdl qnpgtqqnqn aqgdkrlpag gkavntapvp
      301 gqtphdesdr rteprssvsd lvnsltseml mlspgseede ahegcsrenl griqfsvgyn
      361 fqestltvki mkaqelpakd fsgtsdpfvk iyllpdkkhk letkvkrknl nphwnetflf
      421 egfpyekvvq rilylqvldy drfsrndpig evsiplnkvd ltqmqtfwkd lkpcsdgsgs
      481 rgelllslcy npsansiivn iikarnlkam diggtsdpyv kvwlmykdkr vekkktvtmk
      541 rnlnpifnes fafdiptekl rettiiitvm dkdklsrndv igkiylswks gpgevkhwkd
      601 miarprqpva qwhqlka
//
LOCUS       XP_054226430             611 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-7 isoform X6 [Homo sapiens].
ACCESSION   XP_054226430
VERSION     XP_054226430.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370455.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 1% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..611
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..611
                     /product="synaptotagmin-7 isoform X6"
                     /calculated_mol_wt=68347
     Region          343..467
                     /region_name="C2A_Synaptotagmin-7"
                     /note="C2A domain first repeat present in Synaptotagmin 7;
                     cd08386"
                     /db_xref="CDD:176032"
     Site            order(374,380,433,435,441)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:176032"
     Region          475..610
                     /region_name="C2B_Synaptotagmin-7"
                     /note="C2 domain second repeat present in Synaptotagmin 7;
                     cd08405"
                     /db_xref="CDD:176050"
     Site            order(505,511,565,567)
                     /site_type="other"
                     /note="Ca2+ binding pocket [ion binding]"
                     /db_xref="CDD:176050"
     CDS             1..611
                     /gene="SYT7"
                     /gene_synonym="IPCA-7; IPCA7; PCANAP7; SYT-VII; SYTVII"
                     /coded_by="XM_054370455.1:257..2092"
                     /db_xref="GeneID:9066"
                     /db_xref="HGNC:HGNC:11514"
                     /db_xref="MIM:604146"
ORIGIN      
        1 myrdpeaasp gapsrdvllv saiitvslsv tvvlcglchw cqrklgkryk nsletvgtpd
       61 sgrgrsekka indldrdfwn nnestvqqkw ssyppkefil nispyapygd prlslnfeds
      121 tlstattles ipsstgepkc qrprtlmrqq slqqplsqhq rgrqpsqptt sqslgqlqah
      181 masapgpnpr aygrgqarqg tsagskyraa ggrsrsnpgs wdhvvgqirn rgldmksfle
      241 grmvvlslvl glseqddfan ipdlqnpgtq qnqnaqgdkr lpaggkavnt apvpgqtphd
      301 esdrrteprs svsdlvnslt semlmlspgs eedeahegcs renlgriqfs vgynfqestl
      361 tvkimkaqel pakdfsgtsd pfvkiyllpd kkhkletkvk rknlnphwne tflfegfpye
      421 kvvqrilylq vldydrfsrn dpigevsipl nkvdltqmqt fwkdlkpcsd gsgsrgelll
      481 slcynpsans iivniikarn lkamdiggts dpyvkvwlmy kdkrvekkkt vtmkrnlnpi
      541 fnesfafdip teklrettii itvmdkdkls rndvigkiyl swksgpgevk hwkdmiarpr
      601 qpvaqwhqlk a
//
LOCUS       XP_054226431             528 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-7 isoform X7 [Homo sapiens].
ACCESSION   XP_054226431
VERSION     XP_054226431.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370456.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..528
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..528
                     /product="synaptotagmin-7 isoform X7"
                     /calculated_mol_wt=58530
     Region          260..384
                     /region_name="C2A_Synaptotagmin-7"
                     /note="C2A domain first repeat present in Synaptotagmin 7;
                     cd08386"
                     /db_xref="CDD:176032"
     Site            order(291,297,350,352,358)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:176032"
     Region          392..527
                     /region_name="C2B_Synaptotagmin-7"
                     /note="C2 domain second repeat present in Synaptotagmin 7;
                     cd08405"
                     /db_xref="CDD:176050"
     Site            order(422,428,482,484)
                     /site_type="other"
                     /note="Ca2+ binding pocket [ion binding]"
                     /db_xref="CDD:176050"
     CDS             1..528
                     /gene="SYT7"
                     /gene_synonym="IPCA-7; IPCA7; PCANAP7; SYT-VII; SYTVII"
                     /coded_by="XM_054370456.1:60..1646"
                     /db_xref="GeneID:9066"
                     /db_xref="HGNC:HGNC:11514"
                     /db_xref="MIM:604146"
ORIGIN      
        1 mrvmhlapgp gspselraps rdvllvsaii tvslsvtvvl cglchwcqrk lgkryknsle
       61 tvgtpdsgrg rsekkaindl drdfwnnnes tvqqkwssyp pkefilnisp yapygdprls
      121 lngtllsgak vaaaaglave regrlgekpa pvpppgedal rsggaapsep gsggkagrgr
      181 wrtvqshlaa gklnlsklpa ggkavntapv pgqtphdesd rrteprssvs dlvnsltsem
      241 lmlspgseed eahegcsren lgriqfsvgy nfqestltvk imkaqelpak dfsgtsdpfv
      301 kiyllpdkkh kletkvkrkn lnphwnetfl fegfpyekvv qrilylqvld ydrfsrndpi
      361 gevsiplnkv dltqmqtfwk dlkpcsdgsg srgelllslc ynpsansiiv niikarnlka
      421 mdiggtsdpy vkvwlmykdk rvekkktvtm krnlnpifne sfafdiptek lrettiiitv
      481 mdkdklsrnd vigkiylswk sgpgevkhwk dmiarprqpv aqwhqlka
//
LOCUS       XP_054226432             484 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-7 isoform X8 [Homo sapiens].
ACCESSION   XP_054226432
VERSION     XP_054226432.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370457.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..484
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..484
                     /product="synaptotagmin-7 isoform X8"
                     /calculated_mol_wt=53332
     Region          216..340
                     /region_name="C2A_Synaptotagmin-7"
                     /note="C2A domain first repeat present in Synaptotagmin 7;
                     cd08386"
                     /db_xref="CDD:176032"
     Site            order(247,253,306,308,314)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:176032"
     Region          348..483
                     /region_name="C2B_Synaptotagmin-7"
                     /note="C2 domain second repeat present in Synaptotagmin 7;
                     cd08405"
                     /db_xref="CDD:176050"
     Site            order(378,384,438,440)
                     /site_type="other"
                     /note="Ca2+ binding pocket [ion binding]"
                     /db_xref="CDD:176050"
     CDS             1..484
                     /gene="SYT7"
                     /gene_synonym="IPCA-7; IPCA7; PCANAP7; SYT-VII; SYTVII"
                     /coded_by="XM_054370457.1:23..1477"
                     /db_xref="GeneID:9066"
                     /db_xref="HGNC:HGNC:11514"
                     /db_xref="MIM:604146"
ORIGIN      
        1 mrvmhlapgp gspselraps rdvllvsaii tvslsvtvvl cglchwcqrk lgkryknsle
       61 tvgtpdsgrg rsekkaingt llsgakvaaa aglaveregr lgekpapvpp pgedalrsgg
      121 aapsepgsgg kagrgrwrtv qshlaagkln lsklpaggka vntapvpgqt phdesdrrte
      181 prssvsdlvn sltsemlmls pgseedeahe gcsrenlgri qfsvgynfqe stltvkimka
      241 qelpakdfsg tsdpfvkiyl lpdkkhklet kvkrknlnph wnetflfegf pyekvvqril
      301 ylqvldydrf srndpigevs iplnkvdltq mqtfwkdlkp csdgsgsrge lllslcynps
      361 ansiivniik arnlkamdig gtsdpyvkvw lmykdkrvek kktvtmkrnl npifnesfaf
      421 dipteklret tiiitvmdkd klsrndvigk iylswksgpg evkhwkdmia rprqpvaqwh
      481 qlka
//
LOCUS       XP_054226433             453 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-7 isoform X9 [Homo sapiens].
ACCESSION   XP_054226433
VERSION     XP_054226433.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370458.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..453
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..453
                     /product="synaptotagmin-7 isoform X9"
                     /calculated_mol_wt=51211
     Region          185..309
                     /region_name="C2A_Synaptotagmin-7"
                     /note="C2A domain first repeat present in Synaptotagmin 7;
                     cd08386"
                     /db_xref="CDD:176032"
     Site            order(216,222,275,277,283)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:176032"
     Region          317..452
                     /region_name="C2B_Synaptotagmin-7"
                     /note="C2 domain second repeat present in Synaptotagmin 7;
                     cd08405"
                     /db_xref="CDD:176050"
     Site            order(347,353,407,409)
                     /site_type="other"
                     /note="Ca2+ binding pocket [ion binding]"
                     /db_xref="CDD:176050"
     CDS             1..453
                     /gene="SYT7"
                     /gene_synonym="IPCA-7; IPCA7; PCANAP7; SYT-VII; SYTVII"
                     /coded_by="XM_054370458.1:86..1447"
                     /db_xref="GeneID:9066"
                     /db_xref="HGNC:HGNC:11514"
                     /db_xref="MIM:604146"
ORIGIN      
        1 mrvmhlapgp gspselraps rdvllvsaii tvslsvtvvl cglchwcqrk lgkryknsle
       61 tvgtpdsgrg rsekkaindl drdfwnnnes tvqqkwssyp pkefilnisp yapygdprls
      121 lklpaggkav ntapvpgqtp hdesdrrtep rssvsdlvns ltsemlmlsp gseedeaheg
      181 csrenlgriq fsvgynfqes tltvkimkaq elpakdfsgt sdpfvkiyll pdkkhkletk
      241 vkrknlnphw netflfegfp yekvvqrily lqvldydrfs rndpigevsi plnkvdltqm
      301 qtfwkdlkpc sdgsgsrgel llslcynpsa nsiivniika rnlkamdigg tsdpyvkvwl
      361 mykdkrvekk ktvtmkrnln pifnesfafd ipteklrett iiitvmdkdk lsrndvigki
      421 ylswksgpge vkhwkdmiar prqpvaqwhq lka
//
LOCUS       XP_054226434             449 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-7 isoform X10 [Homo sapiens].
ACCESSION   XP_054226434
VERSION     XP_054226434.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370459.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..449
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..449
                     /product="synaptotagmin-7 isoform X10"
                     /calculated_mol_wt=50481
     Region          181..305
                     /region_name="C2A_Synaptotagmin-7"
                     /note="C2A domain first repeat present in Synaptotagmin 7;
                     cd08386"
                     /db_xref="CDD:176032"
     Site            order(212,218,271,273,279)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:176032"
     Region          313..448
                     /region_name="C2B_Synaptotagmin-7"
                     /note="C2 domain second repeat present in Synaptotagmin 7;
                     cd08405"
                     /db_xref="CDD:176050"
     Site            order(343,349,403,405)
                     /site_type="other"
                     /note="Ca2+ binding pocket [ion binding]"
                     /db_xref="CDD:176050"
     CDS             1..449
                     /gene="SYT7"
                     /gene_synonym="IPCA-7; IPCA7; PCANAP7; SYT-VII; SYTVII"
                     /coded_by="XM_054370459.1:2885..4234"
                     /db_xref="GeneID:9066"
                     /db_xref="HGNC:HGNC:11514"
                     /db_xref="MIM:604146"
ORIGIN      
        1 mtrrgtwthh ttvepppsrl gadgieqase dwgqwppqrp tmqandwrvg gfwgtgrmgt
       61 ppkispigvv kpqspgveaa rrmgpghgsp gktrcprgle yrscrpagdg scwglqrrlp
      121 aggkavntap vpgqtphdes drrteprssv sdlvnsltse mlmlspgsee deahegcsre
      181 nlgriqfsvg ynfqestltv kimkaqelpa kdfsgtsdpf vkiyllpdkk hkletkvkrk
      241 nlnphwnetf lfegfpyekv vqrilylqvl dydrfsrndp igevsiplnk vdltqmqtfw
      301 kdlkpcsdgs gsrgelllsl cynpsansii vniikarnlk amdiggtsdp yvkvwlmykd
      361 krvekkktvt mkrnlnpifn esfafdipte klrettiiit vmdkdklsrn dvigkiylsw
      421 ksgpgevkhw kdmiarprqp vaqwhqlka
//
LOCUS       XP_054226435             421 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-7 isoform X11 [Homo sapiens].
ACCESSION   XP_054226435
VERSION     XP_054226435.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370460.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..421
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..421
                     /product="synaptotagmin-7 isoform X11"
                     /calculated_mol_wt=45035
     CDS             1..421
                     /gene="SYT7"
                     /gene_synonym="IPCA-7; IPCA7; PCANAP7; SYT-VII; SYTVII"
                     /coded_by="XM_054370460.1:65..1330"
                     /db_xref="GeneID:9066"
                     /db_xref="HGNC:HGNC:11514"
                     /db_xref="MIM:604146"
ORIGIN      
        1 mrvmhlapgp gspselraps rdvllvsaii tvslsvtvvl cglchwcqrk lgkryknsle
       61 tvgtpdsgrg rsekkaindl drdfwnnnes tvqqkwssyp pkefilnisp yapygdprls
      121 lngtllsgak vaaaaglave regrlgekpa pvpppgedal rsggaapsep gsggkagrgr
      181 wrtvqshlaa gklnlsnfed stlstattle sipsstgepk cqrprtlmrq qslqqplsqh
      241 qrgrqpsqpt tsqslgqlqa hmasapgpnp raygrgqarq gtsagskyra aggrsrsnpg
      301 swdhvvgqir nrgldmksfl pwglfpsprs slgalfteqe tstlslgeek grrkgkhwqd
      361 igilkaskfl gasclssets arasradgst algetphpkr pchasfpypc ewpmasktcc
      421 l
//
LOCUS       XP_054226436             409 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-7 isoform X12 [Homo sapiens].
ACCESSION   XP_054226436
VERSION     XP_054226436.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370461.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..409
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..409
                     /product="synaptotagmin-7 isoform X12"
                     /calculated_mol_wt=46012
     Region          141..265
                     /region_name="C2A_Synaptotagmin-7"
                     /note="C2A domain first repeat present in Synaptotagmin 7;
                     cd08386"
                     /db_xref="CDD:176032"
     Site            order(172,178,231,233,239)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:176032"
     Region          273..408
                     /region_name="C2B_Synaptotagmin-7"
                     /note="C2 domain second repeat present in Synaptotagmin 7;
                     cd08405"
                     /db_xref="CDD:176050"
     Site            order(303,309,363,365)
                     /site_type="other"
                     /note="Ca2+ binding pocket [ion binding]"
                     /db_xref="CDD:176050"
     CDS             1..409
                     /gene="SYT7"
                     /gene_synonym="IPCA-7; IPCA7; PCANAP7; SYT-VII; SYTVII"
                     /coded_by="XM_054370461.1:82..1311"
                     /db_xref="GeneID:9066"
                     /db_xref="HGNC:HGNC:11514"
                     /db_xref="MIM:604146"
ORIGIN      
        1 mrvmhlapgp gspselraps rdvllvsaii tvslsvtvvl cglchwcqrk lgkryknsle
       61 tvgtpdsgrg rsekkaiklp aggkavntap vpgqtphdes drrteprssv sdlvnsltse
      121 mlmlspgsee deahegcsre nlgriqfsvg ynfqestltv kimkaqelpa kdfsgtsdpf
      181 vkiyllpdkk hkletkvkrk nlnphwnetf lfegfpyekv vqrilylqvl dydrfsrndp
      241 igevsiplnk vdltqmqtfw kdlkpcsdgs gsrgelllsl cynpsansii vniikarnlk
      301 amdiggtsdp yvkvwlmykd krvekkktvt mkrnlnpifn esfafdipte klrettiiit
      361 vmdkdklsrn dvigkiylsw ksgpgevkhw kdmiarprqp vaqwhqlka
//
LOCUS       XP_054226437             547 aa            linear   PRI 05-AUG-2025
DEFINITION  U4/U6.U5 tri-snRNP-associated protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_054226437
VERSION     XP_054226437.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370462.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..547
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..547
                     /product="U4/U6.U5 tri-snRNP-associated protein 1 isoform
                     X1"
                     /calculated_mol_wt=60959
     Region          117..137
                     /region_name="HIND"
                     /note="HIND motif; pfam19252"
                     /db_xref="CDD:466011"
     Region          165..>399
                     /region_name="SART-1"
                     /note="SART-1 family; pfam03343"
                     /db_xref="CDD:460888"
     CDS             1..547
                     /gene="SART1"
                     /gene_synonym="Ara1; HAF; HOMS1; SART1259; SNRNP110;
                     Snu66"
                     /coded_by="XM_054370462.1:48..1691"
                     /db_xref="GeneID:9092"
                     /db_xref="HGNC:HGNC:10538"
                     /db_xref="MIM:605941"
ORIGIN      
        1 mgsskkhrge keaagttaaa gtggateqpp rhrehkkhkh rsggsggsgg errkrsrerg
       61 gergsgrrga eaearssthg rersqaepse rrvkrekrdd gyeaaasskt ssgdasslsi
      121 eetnklrakl glkplevnai kkeagtkeep vtadvinpma lrqreelrek laaakekrll
      181 nqklgkiktl geddpwlddt aawiersrql qkekdlaekr aklleemdqe fgvstlveee
      241 fgqrrqdlys ardlqgltve haidsfrege tmiltlkdkg vlqeeedvlv nvnlvdkera
      301 eknvelrkkk pdylpyaede svddlaqqkp rsilskydee legerphsfr leqggtadgl
      361 rereleeira klrlqaqsls tvgprlasey ltpeemvtfk ktkrrvkkir kkekevvvra
      421 ddllplgdqt qdgdfgsrlr grgrrrvsev eeekepvpqp lpsddtrven mdisdeeegg
      481 apppgspqvl eedeaelelq kqlekgrrlr qlqqlqqlrd sgekplpppg ggdceeagvs
      541 paglggg
//
LOCUS       XP_054226438             605 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin carboxyl-terminal hydrolase 2 isoform X1 [Homo sapiens].
ACCESSION   XP_054226438
VERSION     XP_054226438.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370463.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..605
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..605
                     /product="ubiquitin carboxyl-terminal hydrolase 2 isoform
                     X1"
                     /calculated_mol_wt=67941
     Region          267..596
                     /region_name="UCH"
                     /note="Ubiquitin carboxyl-terminal hydrolase; pfam00443"
                     /db_xref="CDD:425685"
     Site            order(271,276,557,575)
                     /site_type="active"
                     /db_xref="CDD:239139"
     CDS             1..605
                     /gene="USP2"
                     /gene_synonym="UBP41; USP9"
                     /coded_by="XM_054370463.1:235..2052"
                     /db_xref="GeneID:9099"
                     /db_xref="HGNC:HGNC:12618"
                     /db_xref="MIM:604725"
ORIGIN      
        1 msqlsstlkr ytesarytda hyaksgygay tpssyganla asllekeklg fkpvptssfl
       61 trprtygpss lldydrgrpl lrpditgggk raesqtrgte rplgsglsgg sgfpygvtnn
      121 clsylpinay dqgvtltqkl dsqsdlardf sslrtsdsyr idprnlgrsp mlartrkelc
      181 tlqglyqtas cpeylvdyle nygrkgsasq vpsqappsrv peiisptyrp igrytlwetg
      241 kgqapgpsrs sspgrdgmns ksaqglaglr nlgntcfmns ilqclsntre lrdyclqrly
      301 mrdlhhgsna htalveefak liqtiwtssp ndvvspsefk tqiqryaprf vgynqqdaqe
      361 flrflldglh nevnrvtlrp ksnpenldhl pddekgrqmw rkyleredsr igdlfvgqlk
      421 ssltctdcgy cstvfdpfwd lslpiakrgy pevtlmdcmr lftkedvldg dekptccrcr
      481 grkrcikkfs iqrfpkilvl hlkrfsesri rtsklttfvn fplrdldlre fasentnhav
      541 ynlyavsnhs gttmgghyta ycrspgtgew htfndssvtp msssqvrtsd ayllfyelas
      601 ppsrm
//
LOCUS       XP_054226439             605 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin carboxyl-terminal hydrolase 2 isoform X1 [Homo sapiens].
ACCESSION   XP_054226439
VERSION     XP_054226439.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370464.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..605
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..605
                     /product="ubiquitin carboxyl-terminal hydrolase 2 isoform
                     X1"
                     /calculated_mol_wt=67941
     Region          267..596
                     /region_name="UCH"
                     /note="Ubiquitin carboxyl-terminal hydrolase; pfam00443"
                     /db_xref="CDD:425685"
     Site            order(271,276,557,575)
                     /site_type="active"
                     /db_xref="CDD:239139"
     CDS             1..605
                     /gene="USP2"
                     /gene_synonym="UBP41; USP9"
                     /coded_by="XM_054370464.1:284..2101"
                     /db_xref="GeneID:9099"
                     /db_xref="HGNC:HGNC:12618"
                     /db_xref="MIM:604725"
ORIGIN      
        1 msqlsstlkr ytesarytda hyaksgygay tpssyganla asllekeklg fkpvptssfl
       61 trprtygpss lldydrgrpl lrpditgggk raesqtrgte rplgsglsgg sgfpygvtnn
      121 clsylpinay dqgvtltqkl dsqsdlardf sslrtsdsyr idprnlgrsp mlartrkelc
      181 tlqglyqtas cpeylvdyle nygrkgsasq vpsqappsrv peiisptyrp igrytlwetg
      241 kgqapgpsrs sspgrdgmns ksaqglaglr nlgntcfmns ilqclsntre lrdyclqrly
      301 mrdlhhgsna htalveefak liqtiwtssp ndvvspsefk tqiqryaprf vgynqqdaqe
      361 flrflldglh nevnrvtlrp ksnpenldhl pddekgrqmw rkyleredsr igdlfvgqlk
      421 ssltctdcgy cstvfdpfwd lslpiakrgy pevtlmdcmr lftkedvldg dekptccrcr
      481 grkrcikkfs iqrfpkilvl hlkrfsesri rtsklttfvn fplrdldlre fasentnhav
      541 ynlyavsnhs gttmgghyta ycrspgtgew htfndssvtp msssqvrtsd ayllfyelas
      601 ppsrm
//
LOCUS       XP_054226440             352 aa            linear   PRI 05-AUG-2025
DEFINITION  ubiquitin carboxyl-terminal hydrolase 2 isoform X2 [Homo sapiens].
ACCESSION   XP_054226440
VERSION     XP_054226440.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370465.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..352
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..352
                     /product="ubiquitin carboxyl-terminal hydrolase 2 isoform
                     X2"
                     /calculated_mol_wt=40372
     Region          14..343
                     /region_name="UCH"
                     /note="Ubiquitin carboxyl-terminal hydrolase; pfam00443"
                     /db_xref="CDD:425685"
     Site            order(18,23,304,322)
                     /site_type="active"
                     /db_xref="CDD:239139"
     CDS             1..352
                     /gene="USP2"
                     /gene_synonym="UBP41; USP9"
                     /coded_by="XM_054370465.1:16..1074"
                     /db_xref="GeneID:9099"
                     /db_xref="HGNC:HGNC:12618"
                     /db_xref="MIM:604725"
ORIGIN      
        1 mpppqnsksa qglaglrnlg ntcfmnsilq clsntrelrd yclqrlymrd lhhgsnahta
       61 lveefakliq tiwtsspndv vspsefktqi qryaprfvgy nqqdaqeflr flldglhnev
      121 nrvtlrpksn penldhlpdd ekgrqmwrky leredsrigd lfvgqlkssl tctdcgycst
      181 vfdpfwdlsl piakrgypev tlmdcmrlft kedvldgdek ptccrcrgrk rcikkfsiqr
      241 fpkilvlhlk rfsesrirts klttfvnfpl rdldlrefas entnhavynl yavsnhsgtt
      301 mgghytaycr spgtgewhtf ndssvtpmss sqvrtsdayl lfyelaspps rm
//
LOCUS       XP_054226442             386 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc transporter ZIP13 isoform X1 [Homo sapiens].
ACCESSION   XP_054226442
VERSION     XP_054226442.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370467.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..386
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..386
                     /product="zinc transporter ZIP13 isoform X1"
                     /calculated_mol_wt=40461
     Region          80..380
                     /region_name="Zip"
                     /note="ZIP Zinc transporter; pfam02535"
                     /db_xref="CDD:396884"
     CDS             1..386
                     /gene="SLC39A13"
                     /gene_synonym="EDSSPD3; LZT-Hs9; SCDEDS; ZIP13"
                     /coded_by="XM_054370467.1:39..1199"
                     /db_xref="GeneID:91252"
                     /db_xref="HGNC:HGNC:20859"
                     /db_xref="MIM:608735"
ORIGIN      
        1 mvlpwlicsv splrgmpgcp cpgcgmagpr llfltalale llgraggsqp alrsrgtata
       61 crldnkeses wgallsgerl dtwicsllgs lmvglsgvfp llviplemgt mlrseagawr
      121 lkqllsfalg gllgnvflhl lpeawaytcs aspggegqsl qqqqqlglwv iagiltflal
      181 ekmfldskee gtsqapnkdp taaaaalngg hclaqpaaep glgavvrsik vsgylnllan
      241 tidnfthgla vaasflvskk igllttmail lheiphevgd faillragfd rwsaaklqls
      301 talggllgag faictqspkg vvgcspaaee taawvlpfts ggflyialvn vlpdlleeed
      361 pwrslqqlll lcagivvmvl fslfvd
//
LOCUS       XP_054226444             364 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc transporter ZIP13 isoform X3 [Homo sapiens].
ACCESSION   XP_054226444
VERSION     XP_054226444.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370469.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..364
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..364
                     /product="zinc transporter ZIP13 isoform X3"
                     /calculated_mol_wt=38222
     Region          65..358
                     /region_name="Zip"
                     /note="ZIP Zinc transporter; pfam02535"
                     /db_xref="CDD:396884"
     CDS             1..364
                     /gene="SLC39A13"
                     /gene_synonym="EDSSPD3; LZT-Hs9; SCDEDS; ZIP13"
                     /coded_by="XM_054370469.1:82..1176"
                     /db_xref="GeneID:91252"
                     /db_xref="HGNC:HGNC:20859"
                     /db_xref="MIM:608735"
ORIGIN      
        1 mpgcpcpgcg magprllflt alalellgra ggsqpalrsr gtatacrldn keseswgall
       61 sgerldtwic sllgslmvgl sgvfpllvip lemgtmlrse agawrlkqll sfalggllgn
      121 vflhllpeaw aytcsaspgg egqslqqqqq lglwviagil tflalekmfl dskeegtsqa
      181 pnkdptaaaa alngghclaq paaepglgav vrsikvsgyl nllantidnf thglavaasf
      241 lvskkigllt tmaillheip hevgdfaill ragfdrwsaa klqlstalgg llgagfaict
      301 qspkgveeta awvlpftsgg flyialvnvl pdlleeedpw rslqqllllc agivvmvlfs
      361 lfvd
//
LOCUS       XP_054226445             350 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc transporter ZIP13 isoform X4 [Homo sapiens].
ACCESSION   XP_054226445
VERSION     XP_054226445.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370470.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..350
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..350
                     /product="zinc transporter ZIP13 isoform X4"
                     /calculated_mol_wt=37041
     Region          80..344
                     /region_name="Zip"
                     /note="ZIP Zinc transporter; pfam02535"
                     /db_xref="CDD:396884"
     CDS             1..350
                     /gene="SLC39A13"
                     /gene_synonym="EDSSPD3; LZT-Hs9; SCDEDS; ZIP13"
                     /coded_by="XM_054370470.1:37..1089"
                     /db_xref="GeneID:91252"
                     /db_xref="HGNC:HGNC:20859"
                     /db_xref="MIM:608735"
ORIGIN      
        1 mvlpwlicsv splrgmpgcp cpgcgmagpr llfltalale llgraggsqp alrsrgtata
       61 crldnkeses wgallsgerl dtwicsllgs lmvglsgvfp llviplemgt mlrseagawr
      121 lkqllsfalg gllgnvflhl lpeawaytcs aspggegqsl qqqqqlglwv iagiltflal
      181 ekmfldskee gtsqvsgyln llantidnft hglavaasfl vskkiglltt maillheiph
      241 evgdfaillr agfdrwsaak lqlstalggl lgagfaictq spkgvvgcsp aaeetaawvl
      301 pftsggflyi alvnvlpdll eeedpwrslq qllllcagiv vmvlfslfvd
//
LOCUS       XP_054226446             343 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc transporter ZIP13 isoform X5 [Homo sapiens].
ACCESSION   XP_054226446
VERSION     XP_054226446.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370471.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..343
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..343
                     /product="zinc transporter ZIP13 isoform X5"
                     /calculated_mol_wt=36455
     Region          80..337
                     /region_name="Zip"
                     /note="ZIP Zinc transporter; pfam02535"
                     /db_xref="CDD:396884"
     CDS             1..343
                     /gene="SLC39A13"
                     /gene_synonym="EDSSPD3; LZT-Hs9; SCDEDS; ZIP13"
                     /coded_by="XM_054370471.1:37..1068"
                     /db_xref="GeneID:91252"
                     /db_xref="HGNC:HGNC:20859"
                     /db_xref="MIM:608735"
ORIGIN      
        1 mvlpwlicsv splrgmpgcp cpgcgmagpr llfltalale llgraggsqp alrsrgtata
       61 crldnkeses wgallsgerl dtwicsllgs lmvglsgvfp llviplemgt mlrseagawr
      121 lkqllsfalg gllgnvflhl lpeawaytcs aspggegqsl qqqqqlglwv iagiltflal
      181 ekmfldskee gtsqvsgyln llantidnft hglavaasfl vskkiglltt maillheiph
      241 evgdfaillr agfdrwsaak lqlstalggl lgagfaictq spkgveetaa wvlpftsggf
      301 lyialvnvlp dlleeedpwr slqqllllca givvmvlfsl fvd
//
LOCUS       XP_054226447             340 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc transporter ZIP13 isoform X6 [Homo sapiens].
ACCESSION   XP_054226447
VERSION     XP_054226447.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370472.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..340
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..340
                     /product="zinc transporter ZIP13 isoform X6"
                     /calculated_mol_wt=35482
     Region          80..>313
                     /region_name="Zip"
                     /note="ZIP Zinc transporter; pfam02535"
                     /db_xref="CDD:396884"
     CDS             1..340
                     /gene="SLC39A13"
                     /gene_synonym="EDSSPD3; LZT-Hs9; SCDEDS; ZIP13"
                     /coded_by="XM_054370472.1:39..1061"
                     /db_xref="GeneID:91252"
                     /db_xref="HGNC:HGNC:20859"
                     /db_xref="MIM:608735"
ORIGIN      
        1 mvlpwlicsv splrgmpgcp cpgcgmagpr llfltalale llgraggsqp alrsrgtata
       61 crldnkeses wgallsgerl dtwicsllgs lmvglsgvfp llviplemgt mlrseagawr
      121 lkqllsfalg gllgnvflhl lpeawaytcs aspggegqsl qqqqqlglwv iagiltflal
      181 ekmfldskee gtsqapnkdp taaaaalngg hclaqpaaep glgavvrsik vsgylnllan
      241 tidnfthgla vaasflvskk igllttmail lheiphevgd faillragfd rwsaaklqls
      301 talggllgag faictqspkg rrrqpgscps plaafstspw
//
LOCUS       XP_054226449             328 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc transporter ZIP13 isoform X8 [Homo sapiens].
ACCESSION   XP_054226449
VERSION     XP_054226449.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370474.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..328
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..328
                     /product="zinc transporter ZIP13 isoform X8"
                     /calculated_mol_wt=34802
     Region          65..322
                     /region_name="Zip"
                     /note="ZIP Zinc transporter; pfam02535"
                     /db_xref="CDD:396884"
     CDS             1..328
                     /gene="SLC39A13"
                     /gene_synonym="EDSSPD3; LZT-Hs9; SCDEDS; ZIP13"
                     /coded_by="XM_054370474.1:82..1068"
                     /db_xref="GeneID:91252"
                     /db_xref="HGNC:HGNC:20859"
                     /db_xref="MIM:608735"
ORIGIN      
        1 mpgcpcpgcg magprllflt alalellgra ggsqpalrsr gtatacrldn keseswgall
       61 sgerldtwic sllgslmvgl sgvfpllvip lemgtmlrse agawrlkqll sfalggllgn
      121 vflhllpeaw aytcsaspgg egqslqqqqq lglwviagil tflalekmfl dskeegtsqv
      181 sgylnllant idnfthglav aasflvskki gllttmaill heiphevgdf aillragfdr
      241 wsaaklqlst alggllgagf aictqspkgv eetaawvlpf tsggflyial vnvlpdllee
      301 edpwrslqql lllcagivvm vlfslfvd
//
LOCUS       XP_054226450             310 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc transporter ZIP13 isoform X9 [Homo sapiens].
ACCESSION   XP_054226450
VERSION     XP_054226450.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370475.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..310
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..310
                     /product="zinc transporter ZIP13 isoform X9"
                     /calculated_mol_wt=32655
     Region          80..>254
                     /region_name="Zip"
                     /note="ZIP Zinc transporter; cl00437"
                     /db_xref="CDD:444905"
     CDS             1..310
                     /gene="SLC39A13"
                     /gene_synonym="EDSSPD3; LZT-Hs9; SCDEDS; ZIP13"
                     /coded_by="XM_054370475.1:37..969"
                     /db_xref="GeneID:91252"
                     /db_xref="HGNC:HGNC:20859"
                     /db_xref="MIM:608735"
ORIGIN      
        1 mvlpwlicsv splrgmpgcp cpgcgmagpr llfltalale llgraggsqp alrsrgtata
       61 crldnkeses wgallsgerl dtwicsllgs lmvglsgvfp llviplemgt mlrseagawr
      121 lkqllsfalg gllgnvflhl lpeawaytcs aspggegqsl qqqqqlglwv iagiltflal
      181 ekmfldskee gtsqapnkdp taaaaalngg hclaqpaaep glgavvrsik vsgylnllan
      241 tidnfthgla vaasflvskk sllyfqwptq cpprasseqs kplwnewasg vlspqhrprs
      301 hgsppcrsgs
//
LOCUS       XP_054226451             304 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc transporter ZIP13 isoform X10 [Homo sapiens].
ACCESSION   XP_054226451
VERSION     XP_054226451.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370476.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..304
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..304
                     /product="zinc transporter ZIP13 isoform X10"
                     /calculated_mol_wt=31903
     Region          80..>254
                     /region_name="Zip"
                     /note="ZIP Zinc transporter; cl00437"
                     /db_xref="CDD:444905"
     CDS             1..304
                     /gene="SLC39A13"
                     /gene_synonym="EDSSPD3; LZT-Hs9; SCDEDS; ZIP13"
                     /coded_by="XM_054370476.1:37..951"
                     /db_xref="GeneID:91252"
                     /db_xref="HGNC:HGNC:20859"
                     /db_xref="MIM:608735"
ORIGIN      
        1 mvlpwlicsv splrgmpgcp cpgcgmagpr llfltalale llgraggsqp alrsrgtata
       61 crldnkeses wgallsgerl dtwicsllgs lmvglsgvfp llviplemgt mlrseagawr
      121 lkqllsfalg gllgnvflhl lpeawaytcs aspggegqsl qqqqqlglwv iagiltflal
      181 ekmfldskee gtsqapnkdp taaaaalngg hclaqpaaep glgavvrsik vsgylnllan
      241 tidnfthgla vaasflvskk wptqcppras seqskplwne wasgvlspqh rprshgsppc
      301 rsgs
//
LOCUS       XP_054226452             295 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc transporter ZIP13 isoform X11 [Homo sapiens].
ACCESSION   XP_054226452
VERSION     XP_054226452.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370477.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..295
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..295
                     /product="zinc transporter ZIP13 isoform X11"
                     /calculated_mol_wt=31002
     Region          65..>239
                     /region_name="Zip"
                     /note="ZIP Zinc transporter; cl00437"
                     /db_xref="CDD:444905"
     CDS             1..295
                     /gene="SLC39A13"
                     /gene_synonym="EDSSPD3; LZT-Hs9; SCDEDS; ZIP13"
                     /coded_by="XM_054370477.1:82..969"
                     /db_xref="GeneID:91252"
                     /db_xref="HGNC:HGNC:20859"
                     /db_xref="MIM:608735"
ORIGIN      
        1 mpgcpcpgcg magprllflt alalellgra ggsqpalrsr gtatacrldn keseswgall
       61 sgerldtwic sllgslmvgl sgvfpllvip lemgtmlrse agawrlkqll sfalggllgn
      121 vflhllpeaw aytcsaspgg egqslqqqqq lglwviagil tflalekmfl dskeegtsqa
      181 pnkdptaaaa alngghclaq paaepglgav vrsikvsgyl nllantidnf thglavaasf
      241 lvskksllyf qwptqcppra sseqskplwn ewasgvlspq hrprshgspp crsgs
//
LOCUS       XP_054226453             289 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc transporter ZIP13 isoform X12 [Homo sapiens].
ACCESSION   XP_054226453
VERSION     XP_054226453.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370478.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..289
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..289
                     /product="zinc transporter ZIP13 isoform X12"
                     /calculated_mol_wt=30250
     Region          65..>239
                     /region_name="Zip"
                     /note="ZIP Zinc transporter; cl00437"
                     /db_xref="CDD:444905"
     CDS             1..289
                     /gene="SLC39A13"
                     /gene_synonym="EDSSPD3; LZT-Hs9; SCDEDS; ZIP13"
                     /coded_by="XM_054370478.1:82..951"
                     /db_xref="GeneID:91252"
                     /db_xref="HGNC:HGNC:20859"
                     /db_xref="MIM:608735"
ORIGIN      
        1 mpgcpcpgcg magprllflt alalellgra ggsqpalrsr gtatacrldn keseswgall
       61 sgerldtwic sllgslmvgl sgvfpllvip lemgtmlrse agawrlkqll sfalggllgn
      121 vflhllpeaw aytcsaspgg egqslqqqqq lglwviagil tflalekmfl dskeegtsqa
      181 pnkdptaaaa alngghclaq paaepglgav vrsikvsgyl nllantidnf thglavaasf
      241 lvskkwptqc pprasseqsk plwnewasgv lspqhrprsh gsppcrsgs
//
LOCUS       XP_054226454             371 aa            linear   PRI 05-AUG-2025
DEFINITION  zinc transporter ZIP13 isoform X13 [Homo sapiens].
ACCESSION   XP_054226454
VERSION     XP_054226454.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370479.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 15% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..371
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..371
                     /product="zinc transporter ZIP13 isoform X13"
                     /calculated_mol_wt=38808
     Region          65..365
                     /region_name="Zip"
                     /note="ZIP Zinc transporter; pfam02535"
                     /db_xref="CDD:396884"
     CDS             1..371
                     /gene="SLC39A13"
                     /gene_synonym="EDSSPD3; LZT-Hs9; SCDEDS; ZIP13"
                     /coded_by="XM_054370479.1:267..1382"
                     /db_xref="GeneID:91252"
                     /db_xref="HGNC:HGNC:20859"
                     /db_xref="MIM:608735"
ORIGIN      
        1 mpgcpcpgcg magprllflt alalellgra ggsqpalrsr gtatacrldn keseswgall
       61 sgerldtwic sllgslmvgl sgvfpllvip lemgtmlrse agawrlkqll sfalggllgn
      121 vflhllpeaw aytcsaspgg egqslqqqqq lglwviagil tflalekmfl dskeegtsqa
      181 pnkdptaaaa alngghclaq paaepglgav vrsikvsgyl nllantidnf thglavaasf
      241 lvskkigllt tmaillheip hevgdfaill ragfdrwsaa klqlstalgg llgagfaict
      301 qspkgvvgcs paaeetaawv lpftsggfly ialvnvlpdl leeedpwrsl qqllllcagi
      361 vvmvlfslfv d
//
LOCUS       XP_054226455             171 aa            linear   PRI 05-AUG-2025
DEFINITION  T-cell surface glycoprotein CD3 delta chain isoform X1 [Homo
            sapiens].
ACCESSION   XP_054226455
VERSION     XP_054226455.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370480.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..171
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..171
                     /product="T-cell surface glycoprotein CD3 delta chain
                     isoform X1"
                     /calculated_mol_wt=18798
     Region          25..94
                     /region_name="IgC1_CD3_gamma_delta"
                     /note="Immunoglobulin (Ig)-like domain of Cluster of
                     Differentiation (CD) 3 gamma and delta chains; member of
                     the C1-set of IgSF domains; cd07691"
                     /db_xref="CDD:409488"
     Site            order(25..26,28,70,85..87,89..93)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:409488"
     Region          25..29
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409488"
     Region          32..37
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409488"
     Region          40..44
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409488"
     Region          46..48
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409488"
     Region          50..53
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409488"
     Region          56..62
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409488"
     Region          68..74
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409488"
     Region          83..91
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409488"
     Region          146..165
                     /region_name="ITAM"
                     /note="Immunoreceptor tyrosine-based activation motif;
                     pfam02189"
                     /db_xref="CDD:426646"
     CDS             1..171
                     /gene="CD3D"
                     /gene_synonym="CD3-DELTA; CD3DELTA; IMD19; T3D"
                     /coded_by="XM_054370480.1:1075..1590"
                     /db_xref="GeneID:915"
                     /db_xref="HGNC:HGNC:1673"
                     /db_xref="MIM:186790"
ORIGIN      
        1 mehstflsgl vlatllsqvs pfkipieele drvfvncnts itwvegtvgt llsditrldl
       61 gkrildprgi yrcngtdiyk dkestvqvhy rmcqscveld patvagiivt dviatlllal
      121 gvfcfaghet grlsgaadtq allrndqvyq plrdrddaqy shlggnwarn k
//
LOCUS       XP_054226456             505 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium- and chloride-dependent glycine transporter 2 isoform X1
            [Homo sapiens].
ACCESSION   XP_054226456
VERSION     XP_054226456.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370481.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..505
                     /product="sodium- and chloride-dependent glycine
                     transporter 2 isoform X1"
                     /calculated_mol_wt=56700
     Region          1..495
                     /region_name="SLC5-6-like_sbd"
                     /note="Solute carrier families 5 and 6-like; solute
                     binding domain; cl00456"
                     /db_xref="CDD:444915"
     CDS             1..505
                     /gene="SLC6A5"
                     /gene_synonym="GLYT-2; GLYT2; HKPX3; NET1"
                     /coded_by="XM_054370481.1:81..1598"
                     /db_xref="GeneID:9152"
                     /db_xref="HGNC:HGNC:11051"
                     /db_xref="MIM:604159"
ORIGIN      
        1 mmlalaglpi fflevslgqf asqgpvsvwk aipalqdscv isdhpkiqik nstfcmtayp
       61 nvtmvnftsq anktfvsgse eyfkyfvlki sagieypgei rwplalclfl awvivyasla
      121 kgiktsgkvv yftatfpyvv lvillirgvt lpgagagiwy fitpnweklt natvwkdaat
      181 qiffslsaaw gglitlssyn kfhnncyrdt livtctnsat sifagfvifs vigfmanerk
      241 vnienvadqg pgiafvvype altrlplspf waiifflmll tlgldtmfat ietivtsisd
      301 efpkylrthk pvftlgccic ffimgfpmit qggiymfqlv dtyaasyalv iiaifelvgi
      361 syvyglqrfc ediemmigfq pnifwkvcwa fvtptiltfi lcfsfyqwep mtygsyrypn
      421 wsmvlgwlml acsviwipim fvikmhlapg rfierlklvc spqpdwgpfl aqhrgerykn
      481 midplgtssl glklpvkdle lgtqc
//
LOCUS       XP_054226457             450 aa            linear   PRI 05-AUG-2025
DEFINITION  sodium- and chloride-dependent glycine transporter 2 isoform X2
            [Homo sapiens].
ACCESSION   XP_054226457
VERSION     XP_054226457.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370482.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..450
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..450
                     /product="sodium- and chloride-dependent glycine
                     transporter 2 isoform X2"
                     /calculated_mol_wt=50769
     Region          <1..440
                     /region_name="SLC5-6-like_sbd"
                     /note="Solute carrier families 5 and 6-like; solute
                     binding domain; cl00456"
                     /db_xref="CDD:444915"
     CDS             1..450
                     /gene="SLC6A5"
                     /gene_synonym="GLYT-2; GLYT2; HKPX3; NET1"
                     /coded_by="XM_054370482.1:239..1591"
                     /db_xref="GeneID:9152"
                     /db_xref="HGNC:HGNC:11051"
                     /db_xref="MIM:604159"
ORIGIN      
        1 mtaypnvtmv nftsqanktf vsgseeyfky fvlkisagie ypgeirwpla lclflawviv
       61 yaslakgikt sgkvvyftat fpyvvlvill irgvtlpgag agiwyfitpn wekltnatvw
      121 kdaatqiffs lsaawgglit lssynkfhnn cyrdtlivtc tnsatsifag fvifsvigfm
      181 anerkvnien vadqgpgiaf vvypealtrl plspfwaiif flmlltlgld tmfatietiv
      241 tsisdefpky lrthkpvftl gccicffimg fpmitqggiy mfqlvdtyaa syalviiaif
      301 elvgisyvyg lqrfcediem migfqpnifw kvcwafvtpt iltfilcfsf yqwepmtygs
      361 yrypnwsmvl gwlmlacsvi wipimfvikm hlapgrfier lklvcspqpd wgpflaqhrg
      421 eryknmidpl gtsslglklp vkdlelgtqc
//
LOCUS       XP_054226458             597 aa            linear   PRI 05-AUG-2025
DEFINITION  proprotein convertase subtilisin/kexin type 7 isoform X1 [Homo
            sapiens].
ACCESSION   XP_054226458
VERSION     XP_054226458.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370483.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..597
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..597
                     /product="proprotein convertase subtilisin/kexin type 7
                     isoform X1"
                     /calculated_mol_wt=64890
     Region          53..141
                     /region_name="S8_pro-domain"
                     /note="Peptidase S8 pro-domain; pfam16470"
                     /db_xref="CDD:465126"
     Region          145..440
                     /region_name="Peptidases_S8_Protein_convertases_Kexins_Fur
                     in-lik"
                     /note="Peptidase S8 family domain in Protein convertases;
                     cd04059"
                     /db_xref="CDD:173789"
     Site            order(147,196,242)
                     /site_type="other"
                     /note="calcium binding site 1 [ion binding]"
                     /db_xref="CDD:173789"
     Site            order(187..188,225,228,270,288,298,329,340,406)
                     /site_type="active"
                     /db_xref="CDD:173789"
     Site            order(187,228,406)
                     /site_type="active"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:173789"
     Site            order(335,365)
                     /site_type="other"
                     /note="calcium binding site 2 [ion binding]"
                     /db_xref="CDD:173789"
     Site            order(343,345,348,350)
                     /site_type="other"
                     /note="calcium binding site 3 [ion binding]"
                     /db_xref="CDD:173789"
     Region          525..594
                     /region_name="P_proprotein"
                     /note="Proprotein convertase P-domain; pfam01483"
                     /db_xref="CDD:460225"
     CDS             1..597
                     /gene="PCSK7"
                     /gene_synonym="LPC; PC7; PC8; SPC7"
                     /coded_by="XM_054370483.1:180..1973"
                     /db_xref="GeneID:9159"
                     /db_xref="HGNC:HGNC:8748"
                     /db_xref="MIM:604872"
ORIGIN      
        1 mpkgrqkvph ldaplglptc lwlelaglfl lvpwvmglag tggpdgqgtg gpswavhles
       61 legdgeeetl eqqadalaqa aglvnagrig elqghylfvq paghrpalev eairqqveav
      121 lagheavrwh seqrllrrak rsvhfndpky pqqwhlnnrr spgrdinvtg vwernvtgrg
      181 vtvvvvddgv ehtiqdiapn yspegsydln sndpdpmphp dvengnhhgt rcageiaavp
      241 nnsfcavgva ygsriagirv ldgpltdsme avafnkhyqi ndiyscswgp dddgktvdgp
      301 hqlgkaalqh gviagrqgfg sifvvasgng gqhndncnyd gyansiytvt igavdeegrm
      361 pfyaeecasm lavtfsggdk mlrsivttdw dlqkgtgcte ghtgtsaaap laagmialml
      421 qvrpcltwrd vqhiivftat ryedrraewv tneagfshsh qhgfgllnaw rlvnaakiwt
      481 svpylasyvs pvlkenkaip qsprslevlw nvsrmdlems glktlehvav tvsithprrg
      541 slelklfcps gmmsligapr smdsdpngfn dwtfstvrcw gerargtyrl virdvgc
//
LOCUS       XP_054226459             596 aa            linear   PRI 05-AUG-2025
DEFINITION  proprotein convertase subtilisin/kexin type 7 isoform X2 [Homo
            sapiens].
ACCESSION   XP_054226459
VERSION     XP_054226459.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370484.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..596
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..596
                     /product="proprotein convertase subtilisin/kexin type 7
                     isoform X2"
                     /calculated_mol_wt=64787
     Region          53..141
                     /region_name="S8_pro-domain"
                     /note="Peptidase S8 pro-domain; pfam16470"
                     /db_xref="CDD:465126"
     Region          145..440
                     /region_name="Peptidases_S8_Protein_convertases_Kexins_Fur
                     in-lik"
                     /note="Peptidase S8 family domain in Protein convertases;
                     cd04059"
                     /db_xref="CDD:173789"
     Site            order(147,196,242)
                     /site_type="other"
                     /note="calcium binding site 1 [ion binding]"
                     /db_xref="CDD:173789"
     Site            order(187..188,225,228,270,288,298,329,340,406)
                     /site_type="active"
                     /db_xref="CDD:173789"
     Site            order(187,228,406)
                     /site_type="active"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:173789"
     Site            order(335,365)
                     /site_type="other"
                     /note="calcium binding site 2 [ion binding]"
                     /db_xref="CDD:173789"
     Site            order(343,345,348,350)
                     /site_type="other"
                     /note="calcium binding site 3 [ion binding]"
                     /db_xref="CDD:173789"
     Region          525..594
                     /region_name="P_proprotein"
                     /note="Proprotein convertase P-domain; pfam01483"
                     /db_xref="CDD:460225"
     CDS             1..596
                     /gene="PCSK7"
                     /gene_synonym="LPC; PC7; PC8; SPC7"
                     /coded_by="XM_054370484.1:180..1970"
                     /db_xref="GeneID:9159"
                     /db_xref="HGNC:HGNC:8748"
                     /db_xref="MIM:604872"
ORIGIN      
        1 mpkgrqkvph ldaplglptc lwlelaglfl lvpwvmglag tggpdgqgtg gpswavhles
       61 legdgeeetl eqqadalaqa aglvnagrig elqghylfvq paghrpalev eairqqveav
      121 lagheavrwh seqrllrrak rsvhfndpky pqqwhlnnrr spgrdinvtg vwernvtgrg
      181 vtvvvvddgv ehtiqdiapn yspegsydln sndpdpmphp dvengnhhgt rcageiaavp
      241 nnsfcavgva ygsriagirv ldgpltdsme avafnkhyqi ndiyscswgp dddgktvdgp
      301 hqlgkaalqh gviagrqgfg sifvvasgng gqhndncnyd gyansiytvt igavdeegrm
      361 pfyaeecasm lavtfsggdk mlrsivttdw dlqkgtgcte ghtgtsaaap laagmialml
      421 qvrpcltwrd vqhiivftat ryedrraewv tneagfshsh qhgfgllnaw rlvnaakiwt
      481 svpylasyvs pvlkenkaip qsprslevlw nvsrmdlems glktlehvav tvsithprrg
      541 slelklfcps gmmsligapr smdsdpngfn dwtfstvrcw gerargtyrl virdvg
//
LOCUS       XP_054226460             560 aa            linear   PRI 05-AUG-2025
DEFINITION  proprotein convertase subtilisin/kexin type 7 isoform X3 [Homo
            sapiens].
ACCESSION   XP_054226460
VERSION     XP_054226460.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370485.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..560
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..560
                     /product="proprotein convertase subtilisin/kexin type 7
                     isoform X3"
                     /calculated_mol_wt=60299
     Region          53..141
                     /region_name="S8_pro-domain"
                     /note="Peptidase S8 pro-domain; pfam16470"
                     /db_xref="CDD:465126"
     Region          145..440
                     /region_name="Peptidases_S8_Protein_convertases_Kexins_Fur
                     in-lik"
                     /note="Peptidase S8 family domain in Protein convertases;
                     cd04059"
                     /db_xref="CDD:173789"
     Site            order(147,196,242)
                     /site_type="other"
                     /note="calcium binding site 1 [ion binding]"
                     /db_xref="CDD:173789"
     Site            order(187..188,225,228,270,288,298,329,340,406)
                     /site_type="active"
                     /db_xref="CDD:173789"
     Site            order(187,228,406)
                     /site_type="active"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:173789"
     Site            order(335,365)
                     /site_type="other"
                     /note="calcium binding site 2 [ion binding]"
                     /db_xref="CDD:173789"
     Site            order(343,345,348,350)
                     /site_type="other"
                     /note="calcium binding site 3 [ion binding]"
                     /db_xref="CDD:173789"
     CDS             1..560
                     /gene="PCSK7"
                     /gene_synonym="LPC; PC7; PC8; SPC7"
                     /coded_by="XM_054370485.1:180..1862"
                     /db_xref="GeneID:9159"
                     /db_xref="HGNC:HGNC:8748"
                     /db_xref="MIM:604872"
ORIGIN      
        1 mpkgrqkvph ldaplglptc lwlelaglfl lvpwvmglag tggpdgqgtg gpswavhles
       61 legdgeeetl eqqadalaqa aglvnagrig elqghylfvq paghrpalev eairqqveav
      121 lagheavrwh seqrllrrak rsvhfndpky pqqwhlnnrr spgrdinvtg vwernvtgrg
      181 vtvvvvddgv ehtiqdiapn yspegsydln sndpdpmphp dvengnhhgt rcageiaavp
      241 nnsfcavgva ygsriagirv ldgpltdsme avafnkhyqi ndiyscswgp dddgktvdgp
      301 hqlgkaalqh gviagrqgfg sifvvasgng gqhndncnyd gyansiytvt igavdeegrm
      361 pfyaeecasm lavtfsggdk mlrsivttdw dlqkgtgcte ghtgtsaaap laagmialml
      421 qvrpcltwrd vqhiivftat ryedrraewv tneagfshsh qhgfgllnaw rlvnaakiwt
      481 svpylasyvs pvlkenkaip qsprslevlw ngiptasmtg psplcdaggr epegptglss
      541 gmsdsnkksl skphfksfyv
//
LOCUS       XP_054226461             557 aa            linear   PRI 05-AUG-2025
DEFINITION  proprotein convertase subtilisin/kexin type 7 isoform X4 [Homo
            sapiens].
ACCESSION   XP_054226461
VERSION     XP_054226461.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370486.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..557
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..557
                     /product="proprotein convertase subtilisin/kexin type 7
                     isoform X4"
                     /calculated_mol_wt=59608
     Region          53..141
                     /region_name="S8_pro-domain"
                     /note="Peptidase S8 pro-domain; pfam16470"
                     /db_xref="CDD:465126"
     Region          145..440
                     /region_name="Peptidases_S8_Protein_convertases_Kexins_Fur
                     in-lik"
                     /note="Peptidase S8 family domain in Protein convertases;
                     cd04059"
                     /db_xref="CDD:173789"
     Site            order(147,196,242)
                     /site_type="other"
                     /note="calcium binding site 1 [ion binding]"
                     /db_xref="CDD:173789"
     Site            order(187..188,225,228,270,288,298,329,340,406)
                     /site_type="active"
                     /db_xref="CDD:173789"
     Site            order(187,228,406)
                     /site_type="active"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:173789"
     Site            order(335,365)
                     /site_type="other"
                     /note="calcium binding site 2 [ion binding]"
                     /db_xref="CDD:173789"
     Site            order(343,345,348,350)
                     /site_type="other"
                     /note="calcium binding site 3 [ion binding]"
                     /db_xref="CDD:173789"
     CDS             1..557
                     /gene="PCSK7"
                     /gene_synonym="LPC; PC7; PC8; SPC7"
                     /coded_by="XM_054370486.1:180..1853"
                     /db_xref="GeneID:9159"
                     /db_xref="HGNC:HGNC:8748"
                     /db_xref="MIM:604872"
ORIGIN      
        1 mpkgrqkvph ldaplglptc lwlelaglfl lvpwvmglag tggpdgqgtg gpswavhles
       61 legdgeeetl eqqadalaqa aglvnagrig elqghylfvq paghrpalev eairqqveav
      121 lagheavrwh seqrllrrak rsvhfndpky pqqwhlnnrr spgrdinvtg vwernvtgrg
      181 vtvvvvddgv ehtiqdiapn yspegsydln sndpdpmphp dvengnhhgt rcageiaavp
      241 nnsfcavgva ygsriagirv ldgpltdsme avafnkhyqi ndiyscswgp dddgktvdgp
      301 hqlgkaalqh gviagrqgfg sifvvasgng gqhndncnyd gyansiytvt igavdeegrm
      361 pfyaeecasm lavtfsggdk mlrsivttdw dlqkgtgcte ghtgtsaaap laagmialml
      421 qvrpcltwrd vqhiivftat ryedrraewv tneagfshsh qhgfgllnaw rlvnaakiwt
      481 svpylasyvs pvlkenkaip qsprslevlw ngiptasmtg psplcdaggr epegptglss
      541 gmsgmshsrs assgngs
//
LOCUS       XP_054226462             557 aa            linear   PRI 05-AUG-2025
DEFINITION  proprotein convertase subtilisin/kexin type 7 isoform X4 [Homo
            sapiens].
ACCESSION   XP_054226462
VERSION     XP_054226462.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370487.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..557
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..557
                     /product="proprotein convertase subtilisin/kexin type 7
                     isoform X4"
                     /calculated_mol_wt=59608
     Region          53..141
                     /region_name="S8_pro-domain"
                     /note="Peptidase S8 pro-domain; pfam16470"
                     /db_xref="CDD:465126"
     Region          145..440
                     /region_name="Peptidases_S8_Protein_convertases_Kexins_Fur
                     in-lik"
                     /note="Peptidase S8 family domain in Protein convertases;
                     cd04059"
                     /db_xref="CDD:173789"
     Site            order(147,196,242)
                     /site_type="other"
                     /note="calcium binding site 1 [ion binding]"
                     /db_xref="CDD:173789"
     Site            order(187..188,225,228,270,288,298,329,340,406)
                     /site_type="active"
                     /db_xref="CDD:173789"
     Site            order(187,228,406)
                     /site_type="active"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:173789"
     Site            order(335,365)
                     /site_type="other"
                     /note="calcium binding site 2 [ion binding]"
                     /db_xref="CDD:173789"
     Site            order(343,345,348,350)
                     /site_type="other"
                     /note="calcium binding site 3 [ion binding]"
                     /db_xref="CDD:173789"
     CDS             1..557
                     /gene="PCSK7"
                     /gene_synonym="LPC; PC7; PC8; SPC7"
                     /coded_by="XM_054370487.1:180..1853"
                     /db_xref="GeneID:9159"
                     /db_xref="HGNC:HGNC:8748"
                     /db_xref="MIM:604872"
ORIGIN      
        1 mpkgrqkvph ldaplglptc lwlelaglfl lvpwvmglag tggpdgqgtg gpswavhles
       61 legdgeeetl eqqadalaqa aglvnagrig elqghylfvq paghrpalev eairqqveav
      121 lagheavrwh seqrllrrak rsvhfndpky pqqwhlnnrr spgrdinvtg vwernvtgrg
      181 vtvvvvddgv ehtiqdiapn yspegsydln sndpdpmphp dvengnhhgt rcageiaavp
      241 nnsfcavgva ygsriagirv ldgpltdsme avafnkhyqi ndiyscswgp dddgktvdgp
      301 hqlgkaalqh gviagrqgfg sifvvasgng gqhndncnyd gyansiytvt igavdeegrm
      361 pfyaeecasm lavtfsggdk mlrsivttdw dlqkgtgcte ghtgtsaaap laagmialml
      421 qvrpcltwrd vqhiivftat ryedrraewv tneagfshsh qhgfgllnaw rlvnaakiwt
      481 svpylasyvs pvlkenkaip qsprslevlw ngiptasmtg psplcdaggr epegptglss
      541 gmsgmshsrs assgngs
//
LOCUS       XP_054226463             556 aa            linear   PRI 05-AUG-2025
DEFINITION  proprotein convertase subtilisin/kexin type 7 isoform X5 [Homo
            sapiens].
ACCESSION   XP_054226463
VERSION     XP_054226463.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370488.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..556
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..556
                     /product="proprotein convertase subtilisin/kexin type 7
                     isoform X5"
                     /calculated_mol_wt=59881
     Region          53..141
                     /region_name="S8_pro-domain"
                     /note="Peptidase S8 pro-domain; pfam16470"
                     /db_xref="CDD:465126"
     Region          145..440
                     /region_name="Peptidases_S8_Protein_convertases_Kexins_Fur
                     in-lik"
                     /note="Peptidase S8 family domain in Protein convertases;
                     cd04059"
                     /db_xref="CDD:173789"
     Site            order(147,196,242)
                     /site_type="other"
                     /note="calcium binding site 1 [ion binding]"
                     /db_xref="CDD:173789"
     Site            order(187..188,225,228,270,288,298,329,340,406)
                     /site_type="active"
                     /db_xref="CDD:173789"
     Site            order(187,228,406)
                     /site_type="active"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:173789"
     Site            order(335,365)
                     /site_type="other"
                     /note="calcium binding site 2 [ion binding]"
                     /db_xref="CDD:173789"
     Site            order(343,345,348,350)
                     /site_type="other"
                     /note="calcium binding site 3 [ion binding]"
                     /db_xref="CDD:173789"
     CDS             1..556
                     /gene="PCSK7"
                     /gene_synonym="LPC; PC7; PC8; SPC7"
                     /coded_by="XM_054370488.1:180..1850"
                     /db_xref="GeneID:9159"
                     /db_xref="HGNC:HGNC:8748"
                     /db_xref="MIM:604872"
ORIGIN      
        1 mpkgrqkvph ldaplglptc lwlelaglfl lvpwvmglag tggpdgqgtg gpswavhles
       61 legdgeeetl eqqadalaqa aglvnagrig elqghylfvq paghrpalev eairqqveav
      121 lagheavrwh seqrllrrak rsvhfndpky pqqwhlnnrr spgrdinvtg vwernvtgrg
      181 vtvvvvddgv ehtiqdiapn yspegsydln sndpdpmphp dvengnhhgt rcageiaavp
      241 nnsfcavgva ygsriagirv ldgpltdsme avafnkhyqi ndiyscswgp dddgktvdgp
      301 hqlgkaalqh gviagrqgfg sifvvasgng gqhndncnyd gyansiytvt igavdeegrm
      361 pfyaeecasm lavtfsggdk mlrsivttdw dlqkgtgcte ghtgtsaaap laagmialml
      421 qvrpcltwrd vqhiivftat ryedrraewv tneagfshsh qhgfgllnaw rlvnaakiwt
      481 svpylasyvs pvlkenkaip qsprslevlw ngiptasmtg psplcdaggr epegptglss
      541 gmsavreche wkipar
//
LOCUS       XP_054226464             426 aa            linear   PRI 05-AUG-2025
DEFINITION  proprotein convertase subtilisin/kexin type 7 isoform X6 [Homo
            sapiens].
ACCESSION   XP_054226464
VERSION     XP_054226464.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370489.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 7% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..426
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..426
                     /product="proprotein convertase subtilisin/kexin type 7
                     isoform X6"
                     /calculated_mol_wt=47549
     Region          <1..81
                     /region_name="Peptidases_S8_S53"
                     /note="Peptidase domain in the S8 and S53 families;
                     cl10459"
                     /db_xref="CDD:415849"
     Region          166..253
                     /region_name="P_proprotein"
                     /note="Proprotein convertase P-domain; pfam01483"
                     /db_xref="CDD:460225"
     CDS             1..426
                     /gene="PCSK7"
                     /gene_synonym="LPC; PC7; PC8; SPC7"
                     /coded_by="XM_054370489.1:376..1656"
                     /db_xref="GeneID:9159"
                     /db_xref="HGNC:HGNC:8748"
                     /db_xref="MIM:604872"
ORIGIN      
        1 mpfyaeecas mlavtfsggd kmlrsivttd wdlqkgtgct eghtgtsaaa plaagmialm
       61 lqvrpcltwr dvqhiivfta tryedrraew vtneagfshs hqhgfgllna wrlvnaakiw
      121 tsvpylasyv spvlkenkai pqsprslevl wnvsrmdlem sglktlehva vtvsithprr
      181 gslelklfcp sgmmsligap rsmdsdpngf ndwtfstvrc wgerargtyr lvirdvgdes
      241 fqvgilrqwq ltlygsvwsa vdirdrqrll esamsgkylh ddfalpcppg lkipeedgyt
      301 itpntlktlv lvgcftvfwt vyymlevyls qrnvasnqvc rsgpchwphr srkakeegte
      361 lesvplcssk dpdevetesr gppttsdlla pdlleqgdws lsqnksaldc phqhldvphg
      421 keeqic
//
LOCUS       XP_054226465             439 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-12 isoform X1 [Homo sapiens].
ACCESSION   XP_054226465
VERSION     XP_054226465.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370490.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..439
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..439
                     /product="synaptotagmin-12 isoform X1"
                     /calculated_mol_wt=48216
     Region          170..281
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     Region          302..437
                     /region_name="C2B_Synaptotagmin-12"
                     /note="C2 domain second repeat present in Synaptotagmin
                     12; cd08406"
                     /db_xref="CDD:176051"
     CDS             1..439
                     /gene="SYT12"
                     /gene_synonym="SYT11; sytXII"
                     /coded_by="XM_054370490.1:34..1353"
                     /db_xref="GeneID:91683"
                     /db_xref="HGNC:HGNC:18381"
                     /db_xref="MIM:606436"
ORIGIN      
        1 mktkappvge vtvtaadima vdvaeyhlsv iksppgwevg vyaagalall giaavslwkl
       61 wtsgsfpsps pfpnydyryl qqkygescae arekrvpawn aqrastrgpp srkgslsied
      121 tfesiselgp lelmgreldl apygtlrksq sadslnsiss vsntfgqdft lgqvevsmey
      181 dtashtlnva vmqgkdller eeasfescfm rvsllpdeqi vgisriqrna ysiffdekfs
      241 ipldptalee kslrfsvfgi dedernvstg vvelklsvld lplqpfsgwl ylqdqnkaad
      301 avgeillsls ylptaerltv vvvkaknliw tndkttadpf vkvyllqdgr kmskkktavk
      361 rddpnpvfne amifsvpaiv lqdlslrvtv aesssdgrgd nvghviigps asgmgtthwn
      421 qmlatlrrpv smwhavrrn
//
LOCUS       XP_054226466             456 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-12 isoform X2 [Homo sapiens].
ACCESSION   XP_054226466
VERSION     XP_054226466.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370491.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..456
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..456
                     /product="synaptotagmin-12 isoform X2"
                     /calculated_mol_wt=50125
     Region          187..298
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     Region          319..454
                     /region_name="C2B_Synaptotagmin-12"
                     /note="C2 domain second repeat present in Synaptotagmin
                     12; cd08406"
                     /db_xref="CDD:176051"
     CDS             1..456
                     /gene="SYT12"
                     /gene_synonym="SYT11; sytXII"
                     /coded_by="XM_054370491.1:1065..2435"
                     /db_xref="GeneID:91683"
                     /db_xref="HGNC:HGNC:18381"
                     /db_xref="MIM:606436"
ORIGIN      
        1 mshntqtnii fhspgnemkt kappvgevtv taadimavdv aeyhlsviks ppgwevgvya
       61 agalallgia avslwklwts gsfpspspfp nydyrylqqk ygescaeare krvpawnaqr
      121 astrgppsrk gslsiedtfe siselgplel mgreldlapy gtlrksqsad slnsissvsn
      181 tfgqdftlgq vevsmeydta shtlnvavmq gkdllereea sfescfmrvs llpdeqivgi
      241 sriqrnaysi ffdekfsipl dptaleeksl rfsvfgided ernvstgvve lklsvldlpl
      301 qpfsgwlylq dqnkaadavg eillslsylp taerltvvvv kaknliwtnd kttadpfvkv
      361 yllqdgrkms kkktavkrdd pnpvfneami fsvpaivlqd lslrvtvaes ssdgrgdnvg
      421 hviigpsasg mgtthwnqml atlrrpvsmw havrrn
//
LOCUS       XP_054226467             439 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-12 isoform X1 [Homo sapiens].
ACCESSION   XP_054226467
VERSION     XP_054226467.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370492.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..439
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..439
                     /product="synaptotagmin-12 isoform X1"
                     /calculated_mol_wt=48216
     Region          170..281
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     Region          302..437
                     /region_name="C2B_Synaptotagmin-12"
                     /note="C2 domain second repeat present in Synaptotagmin
                     12; cd08406"
                     /db_xref="CDD:176051"
     CDS             1..439
                     /gene="SYT12"
                     /gene_synonym="SYT11; sytXII"
                     /coded_by="XM_054370492.1:924..2243"
                     /db_xref="GeneID:91683"
                     /db_xref="HGNC:HGNC:18381"
                     /db_xref="MIM:606436"
ORIGIN      
        1 mktkappvge vtvtaadima vdvaeyhlsv iksppgwevg vyaagalall giaavslwkl
       61 wtsgsfpsps pfpnydyryl qqkygescae arekrvpawn aqrastrgpp srkgslsied
      121 tfesiselgp lelmgreldl apygtlrksq sadslnsiss vsntfgqdft lgqvevsmey
      181 dtashtlnva vmqgkdller eeasfescfm rvsllpdeqi vgisriqrna ysiffdekfs
      241 ipldptalee kslrfsvfgi dedernvstg vvelklsvld lplqpfsgwl ylqdqnkaad
      301 avgeillsls ylptaerltv vvvkaknliw tndkttadpf vkvyllqdgr kmskkktavk
      361 rddpnpvfne amifsvpaiv lqdlslrvtv aesssdgrgd nvghviigps asgmgtthwn
      421 qmlatlrrpv smwhavrrn
//
LOCUS       XP_054226468             421 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-12 isoform X3 [Homo sapiens].
ACCESSION   XP_054226468
VERSION     XP_054226468.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370493.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..421
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..421
                     /product="synaptotagmin-12 isoform X3"
                     /calculated_mol_wt=46406
     Region          152..263
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     Region          284..419
                     /region_name="C2B_Synaptotagmin-12"
                     /note="C2 domain second repeat present in Synaptotagmin
                     12; cd08406"
                     /db_xref="CDD:176051"
     CDS             1..421
                     /gene="SYT12"
                     /gene_synonym="SYT11; sytXII"
                     /coded_by="XM_054370493.1:72..1337"
                     /db_xref="GeneID:91683"
                     /db_xref="HGNC:HGNC:18381"
                     /db_xref="MIM:606436"
ORIGIN      
        1 mavdvaeyhl sviksppgwe vgvyaagala llgiaavslw klwtsgsfps pspfpnydyr
       61 ylqqkygesc aearekrvpa wnaqrastrg ppsrkgslsi edtfesisel gplelmgrel
      121 dlapygtlrk sqsadslnsi ssvsntfgqd ftlgqvevsm eydtashtln vavmqgkdll
      181 ereeasfesc fmrvsllpde qivgisriqr naysiffdek fsipldptal eekslrfsvf
      241 gidedernvs tgvvelklsv ldlplqpfsg wlylqdqnka adavgeills lsylptaerl
      301 tvvvvkaknl iwtndkttad pfvkvyllqd grkmskkkta vkrddpnpvf neamifsvpa
      361 ivlqdlslrv tvaesssdgr gdnvghviig psasgmgtth wnqmlatlrr pvsmwhavrr
      421 n
//
LOCUS       XP_054226469             306 aa            linear   PRI 05-AUG-2025
DEFINITION  synaptotagmin-12 isoform X4 [Homo sapiens].
ACCESSION   XP_054226469
VERSION     XP_054226469.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370494.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..306
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..306
                     /product="synaptotagmin-12 isoform X4"
                     /calculated_mol_wt=33849
     Region          37..148
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     Region          169..304
                     /region_name="C2B_Synaptotagmin-12"
                     /note="C2 domain second repeat present in Synaptotagmin
                     12; cd08406"
                     /db_xref="CDD:176051"
     CDS             1..306
                     /gene="SYT12"
                     /gene_synonym="SYT11; sytXII"
                     /coded_by="XM_054370494.1:2780..3700"
                     /db_xref="GeneID:91683"
                     /db_xref="HGNC:HGNC:18381"
                     /db_xref="MIM:606436"
ORIGIN      
        1 mgreldlapy gtlrksqsad slnsissvsn tfgqdftlgq vevsmeydta shtlnvavmq
       61 gkdllereea sfescfmrvs llpdeqivgi sriqrnaysi ffdekfsipl dptaleeksl
      121 rfsvfgided ernvstgvve lklsvldlpl qpfsgwlylq dqnkaadavg eillslsylp
      181 taerltvvvv kaknliwtnd kttadpfvkv yllqdgrkms kkktavkrdd pnpvfneami
      241 fsvpaivlqd lslrvtvaes ssdgrgdnvg hviigpsasg mgtthwnqml atlrrpvsmw
      301 havrrn
//
LOCUS       XP_054226471             326 aa            linear   PRI 05-AUG-2025
DEFINITION  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)
            isoform X1 [Homo sapiens].
ACCESSION   XP_054226471
VERSION     XP_054226471.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370496.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..326
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..326
                     /product="N-acyl-aromatic-L-amino acid amidohydrolase
                     (carboxylate-forming) isoform X1"
                     /calculated_mol_wt=35723
     Region          11..307
                     /region_name="Peptidase_M14_like"
                     /note="M14 family of metallocarboxypeptidases and related
                     proteins; cl11393"
                     /db_xref="CDD:472171"
     Site            order(21,24,63,70..71,123..124,134,171,175,185)
                     /site_type="active"
                     /db_xref="CDD:349480"
     CDS             1..326
                     /gene="ACY3"
                     /gene_synonym="ACY-3; ASPA2; HCBP1"
                     /coded_by="XM_054370496.1:243..1223"
                     /db_xref="GeneID:91703"
                     /db_xref="HGNC:HGNC:24104"
                     /db_xref="MIM:614413"
ORIGIN      
        1 mcslpvpqep lrrvavtggt hgnemsgvyl arhwlhapae lqrasfsavp vlanpaatsg
       61 crryvdhdln rtftssflkp gsgqlssrpt pddpyevtra relnqllgpk asgqafdfvl
      121 dlhnttanmg tcliaksshe vfamhlcrhl qlqypelscq vflyqrsgee synldsvakn
      181 glglelgpqp qgvlradifs rmrtlvatvl dfielfnqgt afpafemeay rpvgvvdfpr
      241 teaghlagtv hpqlqdrdfq plqpgapifq mfsgedllye gestvypvfi neaayyekgv
      301 afvqtekftf tvpampaltp apspas
//
LOCUS       XP_054226472             326 aa            linear   PRI 05-AUG-2025
DEFINITION  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)
            isoform X1 [Homo sapiens].
ACCESSION   XP_054226472
VERSION     XP_054226472.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370497.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..326
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..326
                     /product="N-acyl-aromatic-L-amino acid amidohydrolase
                     (carboxylate-forming) isoform X1"
                     /calculated_mol_wt=35723
     Region          11..307
                     /region_name="Peptidase_M14_like"
                     /note="M14 family of metallocarboxypeptidases and related
                     proteins; cl11393"
                     /db_xref="CDD:472171"
     Site            order(21,24,63,70..71,123..124,134,171,175,185)
                     /site_type="active"
                     /db_xref="CDD:349480"
     CDS             1..326
                     /gene="ACY3"
                     /gene_synonym="ACY-3; ASPA2; HCBP1"
                     /coded_by="XM_054370497.1:277..1257"
                     /db_xref="GeneID:91703"
                     /db_xref="HGNC:HGNC:24104"
                     /db_xref="MIM:614413"
ORIGIN      
        1 mcslpvpqep lrrvavtggt hgnemsgvyl arhwlhapae lqrasfsavp vlanpaatsg
       61 crryvdhdln rtftssflkp gsgqlssrpt pddpyevtra relnqllgpk asgqafdfvl
      121 dlhnttanmg tcliaksshe vfamhlcrhl qlqypelscq vflyqrsgee synldsvakn
      181 glglelgpqp qgvlradifs rmrtlvatvl dfielfnqgt afpafemeay rpvgvvdfpr
      241 teaghlagtv hpqlqdrdfq plqpgapifq mfsgedllye gestvypvfi neaayyekgv
      301 afvqtekftf tvpampaltp apspas
//
LOCUS       XP_054226473             302 aa            linear   PRI 05-AUG-2025
DEFINITION  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)
            isoform X2 [Homo sapiens].
ACCESSION   XP_054226473
VERSION     XP_054226473.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370498.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..302
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..302
                     /product="N-acyl-aromatic-L-amino acid amidohydrolase
                     (carboxylate-forming) isoform X2"
                     /calculated_mol_wt=33192
     Region          1..283
                     /region_name="Peptidase_M14_like"
                     /note="M14 family of metallocarboxypeptidases and related
                     proteins; cl11393"
                     /db_xref="CDD:472171"
     Site            order(39,46..47,99..100,110,147,151,161)
                     /site_type="active"
                     /db_xref="CDD:349480"
     CDS             1..302
                     /gene="ACY3"
                     /gene_synonym="ACY-3; ASPA2; HCBP1"
                     /coded_by="XM_054370498.1:271..1179"
                     /db_xref="GeneID:91703"
                     /db_xref="HGNC:HGNC:24104"
                     /db_xref="MIM:614413"
ORIGIN      
        1 msgvylarhw lhapaelqra sfsavpvlan paatsgcrry vdhdlnrtft ssflkpgsgq
       61 lssrptpddp yevtrareln qllgpkasgq afdfvldlhn ttanmgtcli aksshevfam
      121 hlcrhlqlqy pelscqvfly qrsgeesynl dsvaknglgl elgpqpqgvl radifsrmrt
      181 lvatvldfie lfnqgtafpa femeayrpvg vvdfprteag hlagtvhpql qdrdfqplqp
      241 gapifqmfsg edllyegest vypvfineaa yyekgvafvq tekftftvpa mpaltpapsp
      301 as
//
LOCUS       XP_054226474             295 aa            linear   PRI 05-AUG-2025
DEFINITION  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)
            isoform X4 [Homo sapiens].
ACCESSION   XP_054226474
VERSION     XP_054226474.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370499.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..295
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..295
                     /product="N-acyl-aromatic-L-amino acid amidohydrolase
                     (carboxylate-forming) isoform X4"
                     /calculated_mol_wt=32551
     Region          1..276
                     /region_name="Peptidase_M14_like"
                     /note="M14 family of metallocarboxypeptidases and related
                     proteins; cl11393"
                     /db_xref="CDD:472171"
     Site            order(39,46..47,92..93,103,140,144,154)
                     /site_type="active"
                     /db_xref="CDD:349480"
     CDS             1..295
                     /gene="ACY3"
                     /gene_synonym="ACY-3; ASPA2; HCBP1"
                     /coded_by="XM_054370499.1:271..1158"
                     /db_xref="GeneID:91703"
                     /db_xref="HGNC:HGNC:24104"
                     /db_xref="MIM:614413"
ORIGIN      
        1 msgvylarhw lhapaelqra sfsavpvlan paatsgcrry vdhdlnrtft ssflnsrptp
       61 ddpyevtrar elnqllgpka sgqafdfvld lhnttanmgt cliaksshev famhlcrhlq
      121 lqypelscqv flyqrsgees ynldsvakng lglelgpqpq gvlradifsr mrtlvatvld
      181 fielfnqgta fpafemeayr pvgvvdfprt eaghlagtvh pqlqdrdfqp lqpgapifqm
      241 fsgedllyeg estvypvfin eaayyekgva fvqtekftft vpampaltpa pspas
//
LOCUS       XP_054226475             198 aa            linear   PRI 05-AUG-2025
DEFINITION  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)
            isoform X3 [Homo sapiens].
ACCESSION   XP_054226475
VERSION     XP_054226475.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370500.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..198
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..198
                     /product="N-acyl-aromatic-L-amino acid amidohydrolase
                     (carboxylate-forming) isoform X3"
                     /calculated_mol_wt=21827
     Region          <1..179
                     /region_name="Peptidase_M14_like"
                     /note="M14 family of metallocarboxypeptidases and related
                     proteins; cl11393"
                     /db_xref="CDD:472171"
     CDS             1..198
                     /gene="ACY3"
                     /gene_synonym="ACY-3; ASPA2; HCBP1"
                     /coded_by="XM_054370500.1:468..1064"
                     /db_xref="GeneID:91703"
                     /db_xref="HGNC:HGNC:24104"
                     /db_xref="MIM:614413"
ORIGIN      
        1 mgtcliakss hevfamhlcr hlqlqypels cqvflyqrsg eesynldsva knglglelgp
       61 qpqgvlradi fsrmrtlvat vldfielfnq gtafpafeme ayrpvgvvdf prteaghlag
      121 tvhpqlqdrd fqplqpgapi fqmfsgedll yegestvypv fineaayyek gvafvqtekf
      181 tftvpampal tpapspas
//
LOCUS       XP_054226476             372 aa            linear   PRI 05-AUG-2025
DEFINITION  5-hydroxytryptamine receptor 3B isoform X1 [Homo sapiens].
ACCESSION   XP_054226476
VERSION     XP_054226476.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370501.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..372
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..372
                     /product="5-hydroxytryptamine receptor 3B isoform X1"
                     /calculated_mol_wt=42318
     Region          1..366
                     /region_name="LIC"
                     /note="Cation transporter family protein; cl42365"
                     /db_xref="CDD:455710"
     Region          2..169
                     /region_name="LGIC_ECD"
                     /note="extracellular domain (ECD) of Cys-loop
                     neurotransmitter-gated ion channels (also known as
                     ligand-gated ion channel (LGIC)); cl28912"
                     /db_xref="CDD:475126"
     Site            order(6..7,14,36,38,47..48,50,52..53,63..65,67,77,79,81,
                     85,107,169)
                     /site_type="other"
                     /note="pentamer interface [polypeptide binding]"
                     /db_xref="CDD:349787"
     CDS             1..372
                     /gene="HTR3B"
                     /gene_synonym="5-HT3B"
                     /coded_by="XM_054370501.1:50..1168"
                     /db_xref="GeneID:9177"
                     /db_xref="HGNC:HGNC:5298"
                     /db_xref="MIM:604654"
ORIGIN      
        1 mmdaenqilk tsvwyqevwn deflswnssm fdeireislp lsaiwapdii inefvdiers
       61 pdlpyvyvns sgtienykpi qvvsacslet yafpfdvqnc sltfksilht vedvdlaflr
      121 spediqhdkk aflndsewel lsvsstysil qssaggfaqi qfnvvmrrhp lvyvvsllip
      181 siflmlvdlg sfylppncra rivfktsvlv gytvfrvnms nqvprsvgst plighfftic
      241 maflvlslak sivlvkflhd eqrggqeqpf lclrgdtdad rprvepraqr avvtesslyg
      301 ehlaqpgtlk evwsqlqsis nylqtqdqtd qqeaewlvll srfdrllfqs ylfmlgiyti
      361 tlcslwalwg gv
//
LOCUS       XP_054226477             343 aa            linear   PRI 05-AUG-2025
DEFINITION  5-hydroxytryptamine receptor 3B isoform X2 [Homo sapiens].
ACCESSION   XP_054226477
VERSION     XP_054226477.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370502.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..343
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..343
                     /product="5-hydroxytryptamine receptor 3B isoform X2"
                     /calculated_mol_wt=38784
     Region          <1..140
                     /region_name="LGIC_ECD"
                     /note="extracellular domain (ECD) of Cys-loop
                     neurotransmitter-gated ion channels (also known as
                     ligand-gated ion channel (LGIC)); cl28912"
                     /db_xref="CDD:475126"
     Region          <2..337
                     /region_name="LIC"
                     /note="Cation transporter family protein; cl42365"
                     /db_xref="CDD:455710"
     CDS             1..343
                     /gene="HTR3B"
                     /gene_synonym="5-HT3B"
                     /coded_by="XM_054370502.1:404..1435"
                     /db_xref="GeneID:9177"
                     /db_xref="HGNC:HGNC:5298"
                     /db_xref="MIM:604654"
ORIGIN      
        1 mfdeireisl plsaiwapdi iinefvdier spdlpyvyvn ssgtienykp iqvvsacsle
       61 tyafpfdvqn csltfksilh tvedvdlafl rspediqhdk kaflndsewe llsvsstysi
      121 lqssaggfaq iqfnvvmrrh plvyvvslli psiflmlvdl gsfylppncr arivfktsvl
      181 vgytvfrvnm snqvprsvgs tplighffti cmaflvlsla ksivlvkflh deqrggqeqp
      241 flclrgdtda drprvepraq ravvtessly gehlaqpgtl kevwsqlqsi snylqtqdqt
      301 dqqeaewlvl lsrfdrllfq sylfmlgiyt itlcslwalw ggv
//
LOCUS       XP_054226478             235 aa            linear   PRI 05-AUG-2025
DEFINITION  5-hydroxytryptamine receptor 3B isoform X3 [Homo sapiens].
ACCESSION   XP_054226478
VERSION     XP_054226478.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370503.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..235
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..235
                     /product="5-hydroxytryptamine receptor 3B isoform X3"
                     /calculated_mol_wt=26758
     Region          18..221
                     /region_name="LGIC_ECD"
                     /note="extracellular domain (ECD) of Cys-loop
                     neurotransmitter-gated ion channels (also known as
                     ligand-gated ion channel (LGIC)); cl28912"
                     /db_xref="CDD:475126"
     Site            order(56,58,64..65,72,94,96,105..106,108,110..111,
                     121..123,125,135,137,139,143,165)
                     /site_type="other"
                     /note="pentamer interface [polypeptide binding]"
                     /db_xref="CDD:349787"
     CDS             1..235
                     /gene="HTR3B"
                     /gene_synonym="5-HT3B"
                     /coded_by="XM_054370503.1:281..988"
                     /db_xref="GeneID:9177"
                     /db_xref="HGNC:HGNC:5298"
                     /db_xref="MIM:604654"
ORIGIN      
        1 mivyfpgila tdthhpqdsa lyhlskqllq kyhkevrpvy nwtkattvyl dlfvhaildv
       61 daenqilkts vwyqevwnde flswnssmfd eireislpls aiwapdiiin efvdierspd
      121 lpyvyvnssg tienykpiqv vsacsletya fpfdvqncsl tfksilhtve dvdlaflrsp
      181 ediqhdkkaf lndsewells vsstysilqs saggfaqiqf ngtsspsawp swfsa
//
LOCUS       XP_054226479             527 aa            linear   PRI 05-AUG-2025
DEFINITION  tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ALKBH8
            isoform X1 [Homo sapiens].
ACCESSION   XP_054226479
VERSION     XP_054226479.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370504.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..527
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..527
                     /product="tRNA
                     (carboxymethyluridine(34)-5-O)-methyltransferase ALKBH8
                     isoform X1"
                     /calculated_mol_wt=59598
     Region          15..197
                     /region_name="2OG-FeII_Oxy"
                     /note="2OG-Fe(II) oxygenase superfamily; cl21496"
                     /db_xref="CDD:473886"
     Region          242..368
                     /region_name="UbiE"
                     /note="Ubiquinone/menaquinone biosynthesis C-methylase
                     UbiE/MenG [Coenzyme transport and metabolism]; COG2226"
                     /db_xref="CDD:441828"
     CDS             1..527
                     /gene="ALKBH8"
                     /gene_synonym="ABH8; MRT71; TRM9; TRMT9; TRMT9A"
                     /coded_by="XM_054370504.1:129..1712"
                     /db_xref="GeneID:91801"
                     /db_xref="HGNC:HGNC:25189"
                     /db_xref="MIM:613306"
ORIGIN      
        1 mvveeiisse eekmllesvd wtedtdnqns qkslkhrrvk hfgyefhyen nnvdkdkpls
       61 gglpdicesf lekwlrkgyi khkpdqmtin qyepgqgipa hidthsafed eivslslgse
      121 ivmdfkhpdg iavpvmlprr sllvmtgesr ylwthgitcr kfdtvqases lksgiitsdv
      181 gdltlskrgl rtsftfrkvr qtpcncsypl vcdsqrketp psfpesdkea srleqeyvhq
      241 vyeeiaghfs strhtpwphi veflkalpsg sivadigcgn gkylginkel ymigcdrsqn
      301 lvdicrerqf qafvcdalav pvrsgscdac isiavihhfa taerrvaalq eivrllrpgg
      361 kaliyvwame qeynkqksky lrgnrnsqgk keemnsdtsv qrslveqmrd mgsrdsassv
      421 prindsqegg cnsrqvsnsk lpvhvnrtsf ysqdvlvpwh lkgnpdkgkp vepfgpigsq
      481 dpspvfhryy hvfregeleg acrtvsdvri lqsyydqgnw cvilqka
//
LOCUS       XP_054226480             357 aa            linear   PRI 05-AUG-2025
DEFINITION  tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ALKBH8
            isoform X2 [Homo sapiens].
ACCESSION   XP_054226480
VERSION     XP_054226480.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370505.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..357
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..357
                     /product="tRNA
                     (carboxymethyluridine(34)-5-O)-methyltransferase ALKBH8
                     isoform X2"
                     /calculated_mol_wt=40380
     Region          4..40
                     /region_name="ALKBH8_N"
                     /note="Alkylated DNA repair protein alkB homolog 8,
                     N-terminal; pfam09004"
                     /db_xref="CDD:117570"
     Region          45..125
                     /region_name="RRM_ALKBH8"
                     /note="RNA recognition motif (RRM) found in alkylated DNA
                     repair protein alkB homolog 8 (ALKBH8) and similar
                     proteins; cd12431"
                     /db_xref="CDD:409865"
     Region          155..337
                     /region_name="2OG-FeII_Oxy"
                     /note="2OG-Fe(II) oxygenase superfamily; cl21496"
                     /db_xref="CDD:473886"
     CDS             1..357
                     /gene="ALKBH8"
                     /gene_synonym="ABH8; MRT71; TRM9; TRMT9; TRMT9A"
                     /coded_by="XM_054370505.1:104..1177"
                     /db_xref="GeneID:91801"
                     /db_xref="HGNC:HGNC:25189"
                     /db_xref="MIM:613306"
ORIGIN      
        1 mfamdsnhqs nyklsktekk flrkqikakh tllrhegiet vsyatqslvv angglgngvs
       61 rnqllpvlek cglvdallmp pnkpysfary rtteeskray vtlngkevvd dlgqkitlyl
      121 nfvekvqwke lrpqalppgl mvveeiisse eekmllesvd wtedtdnqns qkslkhrrvk
      181 hfgyefhyen nnvdkdkpls gglpdicesf lekwlrkgyi khkpdqmtin qyepgqgipa
      241 hidthsafed eivslslgse ivmdfkhpdg iavpvmlprr sllvmtgesr ylwthgitcr
      301 kfdtvqases lksgiitsdv gdltlskrgl rtsftfrkvr qtpcncstli pclgcce
//
LOCUS       XP_054226481             349 aa            linear   PRI 05-AUG-2025
DEFINITION  tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ALKBH8
            isoform X3 [Homo sapiens].
ACCESSION   XP_054226481
VERSION     XP_054226481.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370506.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..349
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..349
                     /product="tRNA
                     (carboxymethyluridine(34)-5-O)-methyltransferase ALKBH8
                     isoform X3"
                     /calculated_mol_wt=39674
     Region          4..40
                     /region_name="ALKBH8_N"
                     /note="Alkylated DNA repair protein alkB homolog 8,
                     N-terminal; pfam09004"
                     /db_xref="CDD:117570"
     Region          45..125
                     /region_name="RRM_ALKBH8"
                     /note="RNA recognition motif (RRM) found in alkylated DNA
                     repair protein alkB homolog 8 (ALKBH8) and similar
                     proteins; cd12431"
                     /db_xref="CDD:409865"
     Region          155..337
                     /region_name="2OG-FeII_Oxy"
                     /note="2OG-Fe(II) oxygenase superfamily; cl21496"
                     /db_xref="CDD:473886"
     CDS             1..349
                     /gene="ALKBH8"
                     /gene_synonym="ABH8; MRT71; TRM9; TRMT9; TRMT9A"
                     /coded_by="XM_054370506.1:104..1153"
                     /db_xref="GeneID:91801"
                     /db_xref="HGNC:HGNC:25189"
                     /db_xref="MIM:613306"
ORIGIN      
        1 mfamdsnhqs nyklsktekk flrkqikakh tllrhegiet vsyatqslvv angglgngvs
       61 rnqllpvlek cglvdallmp pnkpysfary rtteeskray vtlngkevvd dlgqkitlyl
      121 nfvekvqwke lrpqalppgl mvveeiisse eekmllesvd wtedtdnqns qkslkhrrvk
      181 hfgyefhyen nnvdkdkpls gglpdicesf lekwlrkgyi khkpdqmtin qyepgqgipa
      241 hidthsafed eivslslgse ivmdfkhpdg iavpvmlprr sllvmtgesr ylwthgitcr
      301 kfdtvqases lksgiitsdv gdltlskrgl rtsftfrkvr qtpcncnwl
//
LOCUS       XP_054226482             715 aa            linear   PRI 05-AUG-2025
DEFINITION  centromere/kinetochore protein zw10 homolog isoform X1 [Homo
            sapiens].
ACCESSION   XP_054226482
VERSION     XP_054226482.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370507.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..715
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..715
                     /product="centromere/kinetochore protein zw10 homolog
                     isoform X1"
                     /calculated_mol_wt=81394
     Region          27..488
                     /region_name="Zw10"
                     /note="Centromere/kinetochore Zw10; pfam06248"
                     /db_xref="CDD:461861"
     CDS             1..715
                     /gene="ZW10"
                     /gene_synonym="HZW10; KNTC1AP"
                     /coded_by="XM_054370507.1:27..2174"
                     /db_xref="GeneID:9183"
                     /db_xref="HGNC:HGNC:13194"
                     /db_xref="MIM:603954"
ORIGIN      
        1 masfvtevla hsgrlekedl gtrisrltrr veeikgevcn miskkysefl psmqsaqgli
       61 tqvdklsedi dllksriese vrrdlhvstg eftdlkqqle rdsvvlsllk qlqefstaie
      121 eyncaltekk yvtgaqrlee aqkclkllks rkcfdlkilk slsmeltiqk qnilyhlgee
      181 wqklivwkfp pskdtssles ylqtelhlyt eqshkeektp mppissvlla fsvlgelhsk
      241 lksfdlpldt dlenektstv plaemlgdmi wedlseclik nclvysiptn ssklqqyeei
      301 iqsteefena lkemrflkgd ttdllkyarn inshfankkc qdvivaarnl mtseihntvk
      361 iipdskinvp elptpdednk levqkvsntq yhevmnlepe ntldqhsfsl ptcrisesvk
      421 klmelayqtl leattssdqc avqlfysvrn ifhlfhdvvp tyhkenlqkl pqlaaihhnn
      481 cmyiahhllt lghqfrlrla pilcdgtatf vdlvpgfrrl gtecflaqmr aqkgellerl
      541 ssarnfsnmd deenysaask avrqvlhqlk rlgivwqdvl pvniyckamg tllntaisev
      601 igkitaledi stedgdrlys lcktvmdegp qvfaplsees knkkyqeevp vyvpkwmpfk
      661 elmmmlqasl qeigdrwadg kgplaaafss sevkaliral fqnterraaa lakik
//
LOCUS       XP_054226483             910 aa            linear   PRI 05-AUG-2025
DEFINITION  integrator complex subunit 4 isoform X1 [Homo sapiens].
ACCESSION   XP_054226483
VERSION     XP_054226483.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370508.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..910
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..910
                     /product="integrator complex subunit 4 isoform X1"
                     /calculated_mol_wt=102041
     Region          65..222
                     /region_name="HEAT"
                     /note="HEAT repeat [General function prediction only];
                     COG1413"
                     /db_xref="CDD:441023"
     Region          115..143
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          155..182
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          157..309
                     /region_name="HEAT"
                     /note="HEAT repeat [General function prediction only];
                     COG1413"
                     /db_xref="CDD:441023"
     Region          199..221
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Site            order(213..214,217,220..221,250..251,254,257..258,272,
                     300..301,304,307..308,310,339..340,343,346..347,392..393,
                     396)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          233..272
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          282..311
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          320..347
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          360..398
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          <375..466
                     /region_name="HEAT"
                     /note="HEAT repeat [General function prediction only];
                     COG1413"
                     /db_xref="CDD:441023"
     Region          411..441
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          447..475
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          486..512
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     CDS             1..910
                     /gene="INTS4"
                     /gene_synonym="INT4; MST093"
                     /coded_by="XM_054370508.1:26..2758"
                     /db_xref="GeneID:92105"
                     /db_xref="HGNC:HGNC:25048"
                     /db_xref="MIM:611348"
ORIGIN      
        1 maahlkkrvy eeftkvvqpq eeiatkklrl tkpsksaalh idlckatspa dalqyllqfa
       61 rkpveaesve gvvrillehy ykendpsvrl kiasllglls ktagfspdci mddainilqn
      121 ekshqvlaql ldtllaigtk lpenqaiqmr lvdvackhlt dtshgvrnkc lqllgnlgsl
      181 eksvtkdaeg laardvqkii gdyfsdqdpr vrtaaikaml qlherglklh qtiynqackl
      241 lsddyeqvrs aavqliwvvs qlypesivpi pssneeirlv ddafgkichm vsdgswvvrv
      301 qaakllgsme qvsshfleqt ldkklmsdlr rkrtaherak elyssgefss grkwgddapk
      361 eevdtgavnl iesgacgafv hgledemyev riaavealcm laqsspsfae kcldflvdmf
      421 ndeieevrlq sihtmrkisn nitlredqld tvlavledss rdirealhel lcctnvstke
      481 gihlalvell knltkyptdr dsiwkclkfl gsrhptlvlp lvpellsthp ffdtaepdmd
      541 dpayiavlvl ifnaaktcpt mpalfsdhtf rhyaylrdsl shlvpalrlp grklvssavs
      601 psiipqedps qqflqqsler vyslqhldpq gaqellefti rdlqrlgelq selagvadfs
      661 atylrcqlll ikalqeklwn vaaplylkqs dlasaaakqi meetykmefm ysgvenkqvv
      721 iihhmrlqak alqlivtart trgldplfgm cekflqevdf fqryfiadlp hlqdsfvdkl
      781 ldlmprlmts kpaevvkilq tmlrqsaflh lplpeqihka satiiepage sdnplrftsg
      841 lvvaldvdat lehvqdpqnt vkvqvlypdg qaqmihpkpa dfrnpgpgrh rlitqvylsh
      901 tawtgcamkl
//
LOCUS       XP_054226484             658 aa            linear   PRI 05-AUG-2025
DEFINITION  integrator complex subunit 4 isoform X2 [Homo sapiens].
ACCESSION   XP_054226484
VERSION     XP_054226484.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370509.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..658
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..658
                     /product="integrator complex subunit 4 isoform X2"
                     /calculated_mol_wt=73704
     Region          65..222
                     /region_name="HEAT"
                     /note="HEAT repeat [General function prediction only];
                     COG1413"
                     /db_xref="CDD:441023"
     Region          115..143
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          155..182
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          157..309
                     /region_name="HEAT"
                     /note="HEAT repeat [General function prediction only];
                     COG1413"
                     /db_xref="CDD:441023"
     Region          199..221
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Site            order(213..214,217,220..221,250..251,254,257..258,272,
                     300..301,304,307..308,310,339..340,343,346..347,392..393,
                     396)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          233..272
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          282..311
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          320..347
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          360..398
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          <375..466
                     /region_name="HEAT"
                     /note="HEAT repeat [General function prediction only];
                     COG1413"
                     /db_xref="CDD:441023"
     Region          411..441
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          447..475
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          486..512
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     CDS             1..658
                     /gene="INTS4"
                     /gene_synonym="INT4; MST093"
                     /coded_by="XM_054370509.1:26..2002"
                     /db_xref="GeneID:92105"
                     /db_xref="HGNC:HGNC:25048"
                     /db_xref="MIM:611348"
ORIGIN      
        1 maahlkkrvy eeftkvvqpq eeiatkklrl tkpsksaalh idlckatspa dalqyllqfa
       61 rkpveaesve gvvrillehy ykendpsvrl kiasllglls ktagfspdci mddainilqn
      121 ekshqvlaql ldtllaigtk lpenqaiqmr lvdvackhlt dtshgvrnkc lqllgnlgsl
      181 eksvtkdaeg laardvqkii gdyfsdqdpr vrtaaikaml qlherglklh qtiynqackl
      241 lsddyeqvrs aavqliwvvs qlypesivpi pssneeirlv ddafgkichm vsdgswvvrv
      301 qaakllgsme qvsshfleqt ldkklmsdlr rkrtaherak elyssgefss grkwgddapk
      361 eevdtgavnl iesgacgafv hgledemyev riaavealcm laqsspsfae kcldflvdmf
      421 ndeieevrlq sihtmrkisn nitlredqld tvlavledss rdirealhel lcctnvstke
      481 gihlalvell knltkyptdr dsiwkclkfl gsrhptlvlp lvpellsthp ffdtaepdmd
      541 dpayiavlvl ifnaaktcpt mpalfsdhtf rhyaylrdsl shlvpalrlp grklvssavs
      601 psiipqedps qqflqqsler vyslqhldpq gaqellefti rvevspwwpg wsqtpelk
//
LOCUS       XP_054226485             654 aa            linear   PRI 05-AUG-2025
DEFINITION  integrator complex subunit 4 isoform X3 [Homo sapiens].
ACCESSION   XP_054226485
VERSION     XP_054226485.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370510.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..654
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..654
                     /product="integrator complex subunit 4 isoform X3"
                     /calculated_mol_wt=73317
     Region          65..222
                     /region_name="HEAT"
                     /note="HEAT repeat [General function prediction only];
                     COG1413"
                     /db_xref="CDD:441023"
     Region          115..143
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          155..182
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          157..309
                     /region_name="HEAT"
                     /note="HEAT repeat [General function prediction only];
                     COG1413"
                     /db_xref="CDD:441023"
     Region          199..221
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Site            order(213..214,217,220..221,250..251,254,257..258,272,
                     300..301,304,307..308,310,339..340,343,346..347,392..393,
                     396)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          233..272
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          282..311
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          320..347
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          360..398
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          <375..466
                     /region_name="HEAT"
                     /note="HEAT repeat [General function prediction only];
                     COG1413"
                     /db_xref="CDD:441023"
     Region          411..441
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          447..475
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          486..512
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     CDS             1..654
                     /gene="INTS4"
                     /gene_synonym="INT4; MST093"
                     /coded_by="XM_054370510.1:26..1990"
                     /db_xref="GeneID:92105"
                     /db_xref="HGNC:HGNC:25048"
                     /db_xref="MIM:611348"
ORIGIN      
        1 maahlkkrvy eeftkvvqpq eeiatkklrl tkpsksaalh idlckatspa dalqyllqfa
       61 rkpveaesve gvvrillehy ykendpsvrl kiasllglls ktagfspdci mddainilqn
      121 ekshqvlaql ldtllaigtk lpenqaiqmr lvdvackhlt dtshgvrnkc lqllgnlgsl
      181 eksvtkdaeg laardvqkii gdyfsdqdpr vrtaaikaml qlherglklh qtiynqackl
      241 lsddyeqvrs aavqliwvvs qlypesivpi pssneeirlv ddafgkichm vsdgswvvrv
      301 qaakllgsme qvsshfleqt ldkklmsdlr rkrtaherak elyssgefss grkwgddapk
      361 eevdtgavnl iesgacgafv hgledemyev riaavealcm laqsspsfae kcldflvdmf
      421 ndeieevrlq sihtmrkisn nitlredqld tvlavledss rdirealhel lcctnvstke
      481 gihlalvell knltkyptdr dsiwkclkfl gsrhptlvlp lvpellsthp ffdtaepdmd
      541 dpayiavlvl ifnaaktcpt mpalfsdhtf rhyaylrdsl shlvpalrlp grklvssavs
      601 psiipqedps qqflqqsler vyslqhldpq gaqellefti rhllldvkvp rrhr
//
LOCUS       XP_054226486             511 aa            linear   PRI 05-AUG-2025
DEFINITION  integrator complex subunit 4 isoform X4 [Homo sapiens].
ACCESSION   XP_054226486
VERSION     XP_054226486.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370511.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..511
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..511
                     /product="integrator complex subunit 4 isoform X4"
                     /calculated_mol_wt=57154
     Region          65..222
                     /region_name="HEAT"
                     /note="HEAT repeat [General function prediction only];
                     COG1413"
                     /db_xref="CDD:441023"
     Region          115..143
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          155..182
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          157..309
                     /region_name="HEAT"
                     /note="HEAT repeat [General function prediction only];
                     COG1413"
                     /db_xref="CDD:441023"
     Region          199..221
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Site            order(213..214,217,220..221,250..251,254,257..258,272,
                     300..301,304,307..308,310,339..340,343,346..347,392..393,
                     396)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          233..272
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          282..311
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          320..347
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          360..398
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          <375..466
                     /region_name="HEAT"
                     /note="HEAT repeat [General function prediction only];
                     COG1413"
                     /db_xref="CDD:441023"
     Region          411..441
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          447..475
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     CDS             1..511
                     /gene="INTS4"
                     /gene_synonym="INT4; MST093"
                     /coded_by="XM_054370511.1:26..1561"
                     /db_xref="GeneID:92105"
                     /db_xref="HGNC:HGNC:25048"
                     /db_xref="MIM:611348"
ORIGIN      
        1 maahlkkrvy eeftkvvqpq eeiatkklrl tkpsksaalh idlckatspa dalqyllqfa
       61 rkpveaesve gvvrillehy ykendpsvrl kiasllglls ktagfspdci mddainilqn
      121 ekshqvlaql ldtllaigtk lpenqaiqmr lvdvackhlt dtshgvrnkc lqllgnlgsl
      181 eksvtkdaeg laardvqkii gdyfsdqdpr vrtaaikaml qlherglklh qtiynqackl
      241 lsddyeqvrs aavqliwvvs qlypesivpi pssneeirlv ddafgkichm vsdgswvvrv
      301 qaakllgsme qvsshfleqt ldkklmsdlr rkrtaherak elyssgefss grkwgddapk
      361 eevdtgavnl iesgacgafv hgledemyev riaavealcm laqsspsfae kcldflvdmf
      421 ndeieevrlq sihtmrkisn nitlredqld tvlavledss rdirealhel lcctnvstke
      481 gihlalvell knltkyptdr dsiwklrivr p
//
LOCUS       XP_054226487             325 aa            linear   PRI 05-AUG-2025
DEFINITION  glycine N-acyltransferase-like protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_054226487
VERSION     XP_054226487.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370512.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..325
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..325
                     /product="glycine N-acyltransferase-like protein 1 isoform
                     X1"
                     /calculated_mol_wt=37556
     Region          46..230
                     /region_name="Gly_acyl_tr_N"
                     /note="Aralkyl acyl-CoA:amino acid N-acyltransferase;
                     pfam06021"
                     /db_xref="CDD:461802"
     Region          231..319
                     /region_name="Gly_acyl_tr_C"
                     /note="Aralkyl acyl-CoA:amino acid N-acyltransferase,
                     C-terminal region; pfam08444"
                     /db_xref="CDD:117021"
     CDS             1..325
                     /gene="GLYATL1"
                     /gene_synonym="GATF-C; GNAT"
                     /coded_by="XM_054370512.1:164..1141"
                     /db_xref="GeneID:92292"
                     /db_xref="HGNC:HGNC:30519"
                     /db_xref="MIM:614761"
ORIGIN      
        1 mvsqegseve llvspgarse hgrylqdpiv sidlsewlri iefllqglkv ygsvyhinhg
       61 npfnmevlvd swpeyqmvii rpqkqemtdd mdsytnvyrm fskepqksee vlknceivnw
      121 kqrlqiqglq eslgegirva tfsksvkveh sralllvted ilklnassks klgswaetgh
      181 pddefesetp nfkyaqldvs ysglvndnwk rgknerslhy ikrciedlpa acmlgpegvp
      241 vswvtmdpsc evgmaysmek yrrtgnmarv mvrymkylrq knipfyisvl eenedsrrfv
      301 gqfgffeasc ewhqwtcypq nlvpf
//
LOCUS       XP_054226488             325 aa            linear   PRI 05-AUG-2025
DEFINITION  glycine N-acyltransferase-like protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_054226488
VERSION     XP_054226488.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370513.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..325
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..325
                     /product="glycine N-acyltransferase-like protein 1 isoform
                     X1"
                     /calculated_mol_wt=37556
     Region          46..230
                     /region_name="Gly_acyl_tr_N"
                     /note="Aralkyl acyl-CoA:amino acid N-acyltransferase;
                     pfam06021"
                     /db_xref="CDD:461802"
     Region          231..319
                     /region_name="Gly_acyl_tr_C"
                     /note="Aralkyl acyl-CoA:amino acid N-acyltransferase,
                     C-terminal region; pfam08444"
                     /db_xref="CDD:117021"
     CDS             1..325
                     /gene="GLYATL1"
                     /gene_synonym="GATF-C; GNAT"
                     /coded_by="XM_054370513.1:202..1179"
                     /db_xref="GeneID:92292"
                     /db_xref="HGNC:HGNC:30519"
                     /db_xref="MIM:614761"
ORIGIN      
        1 mvsqegseve llvspgarse hgrylqdpiv sidlsewlri iefllqglkv ygsvyhinhg
       61 npfnmevlvd swpeyqmvii rpqkqemtdd mdsytnvyrm fskepqksee vlknceivnw
      121 kqrlqiqglq eslgegirva tfsksvkveh sralllvted ilklnassks klgswaetgh
      181 pddefesetp nfkyaqldvs ysglvndnwk rgknerslhy ikrciedlpa acmlgpegvp
      241 vswvtmdpsc evgmaysmek yrrtgnmarv mvrymkylrq knipfyisvl eenedsrrfv
      301 gqfgffeasc ewhqwtcypq nlvpf
//
LOCUS       XP_054226489             325 aa            linear   PRI 05-AUG-2025
DEFINITION  glycine N-acyltransferase-like protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_054226489
VERSION     XP_054226489.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370514.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..325
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..325
                     /product="glycine N-acyltransferase-like protein 1 isoform
                     X1"
                     /calculated_mol_wt=37556
     Region          46..230
                     /region_name="Gly_acyl_tr_N"
                     /note="Aralkyl acyl-CoA:amino acid N-acyltransferase;
                     pfam06021"
                     /db_xref="CDD:461802"
     Region          231..319
                     /region_name="Gly_acyl_tr_C"
                     /note="Aralkyl acyl-CoA:amino acid N-acyltransferase,
                     C-terminal region; pfam08444"
                     /db_xref="CDD:117021"
     CDS             1..325
                     /gene="GLYATL1"
                     /gene_synonym="GATF-C; GNAT"
                     /coded_by="XM_054370514.1:209..1186"
                     /db_xref="GeneID:92292"
                     /db_xref="HGNC:HGNC:30519"
                     /db_xref="MIM:614761"
ORIGIN      
        1 mvsqegseve llvspgarse hgrylqdpiv sidlsewlri iefllqglkv ygsvyhinhg
       61 npfnmevlvd swpeyqmvii rpqkqemtdd mdsytnvyrm fskepqksee vlknceivnw
      121 kqrlqiqglq eslgegirva tfsksvkveh sralllvted ilklnassks klgswaetgh
      181 pddefesetp nfkyaqldvs ysglvndnwk rgknerslhy ikrciedlpa acmlgpegvp
      241 vswvtmdpsc evgmaysmek yrrtgnmarv mvrymkylrq knipfyisvl eenedsrrfv
      301 gqfgffeasc ewhqwtcypq nlvpf
//
LOCUS       XP_054226490             325 aa            linear   PRI 05-AUG-2025
DEFINITION  glycine N-acyltransferase-like protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_054226490
VERSION     XP_054226490.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370515.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..325
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..325
                     /product="glycine N-acyltransferase-like protein 1 isoform
                     X1"
                     /calculated_mol_wt=37556
     Region          46..230
                     /region_name="Gly_acyl_tr_N"
                     /note="Aralkyl acyl-CoA:amino acid N-acyltransferase;
                     pfam06021"
                     /db_xref="CDD:461802"
     Region          231..319
                     /region_name="Gly_acyl_tr_C"
                     /note="Aralkyl acyl-CoA:amino acid N-acyltransferase,
                     C-terminal region; pfam08444"
                     /db_xref="CDD:117021"
     CDS             1..325
                     /gene="GLYATL1"
                     /gene_synonym="GATF-C; GNAT"
                     /coded_by="XM_054370515.1:247..1224"
                     /db_xref="GeneID:92292"
                     /db_xref="HGNC:HGNC:30519"
                     /db_xref="MIM:614761"
ORIGIN      
        1 mvsqegseve llvspgarse hgrylqdpiv sidlsewlri iefllqglkv ygsvyhinhg
       61 npfnmevlvd swpeyqmvii rpqkqemtdd mdsytnvyrm fskepqksee vlknceivnw
      121 kqrlqiqglq eslgegirva tfsksvkveh sralllvted ilklnassks klgswaetgh
      181 pddefesetp nfkyaqldvs ysglvndnwk rgknerslhy ikrciedlpa acmlgpegvp
      241 vswvtmdpsc evgmaysmek yrrtgnmarv mvrymkylrq knipfyisvl eenedsrrfv
      301 gqfgffeasc ewhqwtcypq nlvpf
//
LOCUS       XP_054226491             325 aa            linear   PRI 05-AUG-2025
DEFINITION  glycine N-acyltransferase-like protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_054226491
VERSION     XP_054226491.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370516.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..325
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..325
                     /product="glycine N-acyltransferase-like protein 1 isoform
                     X1"
                     /calculated_mol_wt=37556
     Region          46..230
                     /region_name="Gly_acyl_tr_N"
                     /note="Aralkyl acyl-CoA:amino acid N-acyltransferase;
                     pfam06021"
                     /db_xref="CDD:461802"
     Region          231..319
                     /region_name="Gly_acyl_tr_C"
                     /note="Aralkyl acyl-CoA:amino acid N-acyltransferase,
                     C-terminal region; pfam08444"
                     /db_xref="CDD:117021"
     CDS             1..325
                     /gene="GLYATL1"
                     /gene_synonym="GATF-C; GNAT"
                     /coded_by="XM_054370516.1:289..1266"
                     /db_xref="GeneID:92292"
                     /db_xref="HGNC:HGNC:30519"
                     /db_xref="MIM:614761"
ORIGIN      
        1 mvsqegseve llvspgarse hgrylqdpiv sidlsewlri iefllqglkv ygsvyhinhg
       61 npfnmevlvd swpeyqmvii rpqkqemtdd mdsytnvyrm fskepqksee vlknceivnw
      121 kqrlqiqglq eslgegirva tfsksvkveh sralllvted ilklnassks klgswaetgh
      181 pddefesetp nfkyaqldvs ysglvndnwk rgknerslhy ikrciedlpa acmlgpegvp
      241 vswvtmdpsc evgmaysmek yrrtgnmarv mvrymkylrq knipfyisvl eenedsrrfv
      301 gqfgffeasc ewhqwtcypq nlvpf
//
LOCUS       XP_054226492             325 aa            linear   PRI 05-AUG-2025
DEFINITION  glycine N-acyltransferase-like protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_054226492
VERSION     XP_054226492.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370517.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..325
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..325
                     /product="glycine N-acyltransferase-like protein 1 isoform
                     X1"
                     /calculated_mol_wt=37556
     Region          46..230
                     /region_name="Gly_acyl_tr_N"
                     /note="Aralkyl acyl-CoA:amino acid N-acyltransferase;
                     pfam06021"
                     /db_xref="CDD:461802"
     Region          231..319
                     /region_name="Gly_acyl_tr_C"
                     /note="Aralkyl acyl-CoA:amino acid N-acyltransferase,
                     C-terminal region; pfam08444"
                     /db_xref="CDD:117021"
     CDS             1..325
                     /gene="GLYATL1"
                     /gene_synonym="GATF-C; GNAT"
                     /coded_by="XM_054370517.1:244..1221"
                     /db_xref="GeneID:92292"
                     /db_xref="HGNC:HGNC:30519"
                     /db_xref="MIM:614761"
ORIGIN      
        1 mvsqegseve llvspgarse hgrylqdpiv sidlsewlri iefllqglkv ygsvyhinhg
       61 npfnmevlvd swpeyqmvii rpqkqemtdd mdsytnvyrm fskepqksee vlknceivnw
      121 kqrlqiqglq eslgegirva tfsksvkveh sralllvted ilklnassks klgswaetgh
      181 pddefesetp nfkyaqldvs ysglvndnwk rgknerslhy ikrciedlpa acmlgpegvp
      241 vswvtmdpsc evgmaysmek yrrtgnmarv mvrymkylrq knipfyisvl eenedsrrfv
      301 gqfgffeasc ewhqwtcypq nlvpf
//
LOCUS       XP_054226493             667 aa            linear   PRI 05-AUG-2025
DEFINITION  T-cell differentiation antigen CD6 isoform X1 [Homo sapiens].
ACCESSION   XP_054226493
VERSION     XP_054226493.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370518.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..667
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..667
                     /product="T-cell differentiation antigen CD6 isoform X1"
                     /calculated_mol_wt=71687
     Region          50..156
                     /region_name="SRCR"
                     /note="Scavenger receptor cysteine-rich domain; pfam00530"
                     /db_xref="CDD:459844"
     Region          161..260
                     /region_name="SR"
                     /note="Scavenger receptor Cys-rich; smart00202"
                     /db_xref="CDD:214555"
     Region          270..361
                     /region_name="SRCR"
                     /note="Scavenger receptor cysteine-rich domain; pfam00530"
                     /db_xref="CDD:459844"
     CDS             1..667
                     /gene="CD6"
                     /gene_synonym="TP120"
                     /coded_by="XM_054370518.1:187..2190"
                     /db_xref="GeneID:923"
                     /db_xref="HGNC:HGNC:1691"
                     /db_xref="MIM:186720"
ORIGIN      
        1 mwlffgitgl ltaalsghps pappdqlnts saeselwepg erlpvrltng ssscsgtvev
       61 rleaswepac galwdsraae avcralgcgg aeaasqlapp tpelppppaa gntsvaanat
      121 lagapallcs gaewrlcevv ehacrsdgrr arvtcaenra lrlvdgggac agrvemlehg
      181 ewgsvcddtw dledahvvcr qlgcgwavqa lpglhftpgr gpihwdqvnc sgaeaylwdc
      241 pglpgqhycg hkedagvvcs ehqswrltgg tdrcegqvev hfrgvwntvc dsewypseak
      301 vlcqslgcgt averpkglph slsgrmyysc ngeeltlsnc swrfnnsnlc sqslaarvlc
      361 sasrslhnls tpevpasvqt vtiessvtvk ienkesrelm llipsivlgi lllgslifia
      421 fillrikgky alpvmvnhqh lpttipagsn syqpvpitip kevfmlpiqv qapppedsds
      481 gsdsdyehyd fsaqppvalt tfynsqrhrv tdeevqqsrf qmppleegle elhashipta
      541 npghcitdpp slgpqyhprs nsesstssge dycnspkskl ppwnpqvfss erssfleqpp
      601 nlelagtqpa fsgppaddss stssgewyqn fqpppqppse eqfgcpgsps pqpdstdndd
      661 yddisaa
//
LOCUS       XP_054226494             636 aa            linear   PRI 05-AUG-2025
DEFINITION  T-cell differentiation antigen CD6 isoform X2 [Homo sapiens].
ACCESSION   XP_054226494
VERSION     XP_054226494.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370519.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..636
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..636
                     /product="T-cell differentiation antigen CD6 isoform X2"
                     /calculated_mol_wt=68325
     Region          50..156
                     /region_name="SRCR"
                     /note="Scavenger receptor cysteine-rich domain; pfam00530"
                     /db_xref="CDD:459844"
     Region          161..260
                     /region_name="SR"
                     /note="Scavenger receptor Cys-rich; smart00202"
                     /db_xref="CDD:214555"
     Region          270..361
                     /region_name="SRCR"
                     /note="Scavenger receptor cysteine-rich domain; pfam00530"
                     /db_xref="CDD:459844"
     CDS             1..636
                     /gene="CD6"
                     /gene_synonym="TP120"
                     /coded_by="XM_054370519.1:187..2097"
                     /db_xref="GeneID:923"
                     /db_xref="HGNC:HGNC:1691"
                     /db_xref="MIM:186720"
ORIGIN      
        1 mwlffgitgl ltaalsghps pappdqlnts saeselwepg erlpvrltng ssscsgtvev
       61 rleaswepac galwdsraae avcralgcgg aeaasqlapp tpelppppaa gntsvaanat
      121 lagapallcs gaewrlcevv ehacrsdgrr arvtcaenra lrlvdgggac agrvemlehg
      181 ewgsvcddtw dledahvvcr qlgcgwavqa lpglhftpgr gpihwdqvnc sgaeaylwdc
      241 pglpgqhycg hkedagvvcs ehqswrltgg tdrcegqvev hfrgvwntvc dsewypseak
      301 vlcqslgcgt averpkglph slsgrmyysc ngeeltlsnc swrfnnsnlc sqslaarvlc
      361 sasrslhnls tpevpasvqt vtiessvtvk ienkesrelm llipsivlgi lllgslifia
      421 fillrikgky vfmlpiqvqa pppedsdsgs dsdyehydfs aqppvalttf ynsqrhrvtd
      481 eevqqsrfqm ppleegleel hashiptanp ghcitdppsl gpqyhprsns esstssgedy
      541 cnspksklpp wnpqvfsser ssfleqppnl elagtqpafs agppaddsss tssgewyqnf
      601 qpppqppsee qfgcpgspsp qpdstdnddy ddisaa
//
LOCUS       XP_054226495             635 aa            linear   PRI 05-AUG-2025
DEFINITION  T-cell differentiation antigen CD6 isoform X3 [Homo sapiens].
ACCESSION   XP_054226495
VERSION     XP_054226495.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370520.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..635
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..635
                     /product="T-cell differentiation antigen CD6 isoform X3"
                     /calculated_mol_wt=68254
     Region          50..156
                     /region_name="SRCR"
                     /note="Scavenger receptor cysteine-rich domain; pfam00530"
                     /db_xref="CDD:459844"
     Region          161..260
                     /region_name="SR"
                     /note="Scavenger receptor Cys-rich; smart00202"
                     /db_xref="CDD:214555"
     Region          270..361
                     /region_name="SRCR"
                     /note="Scavenger receptor cysteine-rich domain; pfam00530"
                     /db_xref="CDD:459844"
     CDS             1..635
                     /gene="CD6"
                     /gene_synonym="TP120"
                     /coded_by="XM_054370520.1:187..2094"
                     /db_xref="GeneID:923"
                     /db_xref="HGNC:HGNC:1691"
                     /db_xref="MIM:186720"
ORIGIN      
        1 mwlffgitgl ltaalsghps pappdqlnts saeselwepg erlpvrltng ssscsgtvev
       61 rleaswepac galwdsraae avcralgcgg aeaasqlapp tpelppppaa gntsvaanat
      121 lagapallcs gaewrlcevv ehacrsdgrr arvtcaenra lrlvdgggac agrvemlehg
      181 ewgsvcddtw dledahvvcr qlgcgwavqa lpglhftpgr gpihwdqvnc sgaeaylwdc
      241 pglpgqhycg hkedagvvcs ehqswrltgg tdrcegqvev hfrgvwntvc dsewypseak
      301 vlcqslgcgt averpkglph slsgrmyysc ngeeltlsnc swrfnnsnlc sqslaarvlc
      361 sasrslhnls tpevpasvqt vtiessvtvk ienkesrelm llipsivlgi lllgslifia
      421 fillrikgky vfmlpiqvqa pppedsdsgs dsdyehydfs aqppvalttf ynsqrhrvtd
      481 eevqqsrfqm ppleegleel hashiptanp ghcitdppsl gpqyhprsns esstssgedy
      541 cnspksklpp wnpqvfsser ssfleqppnl elagtqpafs gppaddssst ssgewyqnfq
      601 pppqppseeq fgcpgspspq pdstdnddyd disaa
//
LOCUS       XP_054226496             633 aa            linear   PRI 05-AUG-2025
DEFINITION  T-cell differentiation antigen CD6 isoform X4 [Homo sapiens].
ACCESSION   XP_054226496
VERSION     XP_054226496.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370521.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..633
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..633
                     /product="T-cell differentiation antigen CD6 isoform X4"
                     /calculated_mol_wt=68053
     Region          50..156
                     /region_name="SRCR"
                     /note="Scavenger receptor cysteine-rich domain; pfam00530"
                     /db_xref="CDD:459844"
     Region          161..260
                     /region_name="SR"
                     /note="Scavenger receptor Cys-rich; smart00202"
                     /db_xref="CDD:214555"
     Region          270..361
                     /region_name="SRCR"
                     /note="Scavenger receptor cysteine-rich domain; pfam00530"
                     /db_xref="CDD:459844"
     CDS             1..633
                     /gene="CD6"
                     /gene_synonym="TP120"
                     /coded_by="XM_054370521.1:187..2088"
                     /db_xref="GeneID:923"
                     /db_xref="HGNC:HGNC:1691"
                     /db_xref="MIM:186720"
ORIGIN      
        1 mwlffgitgl ltaalsghps pappdqlnts saeselwepg erlpvrltng ssscsgtvev
       61 rleaswepac galwdsraae avcralgcgg aeaasqlapp tpelppppaa gntsvaanat
      121 lagapallcs gaewrlcevv ehacrsdgrr arvtcaenra lrlvdgggac agrvemlehg
      181 ewgsvcddtw dledahvvcr qlgcgwavqa lpglhftpgr gpihwdqvnc sgaeaylwdc
      241 pglpgqhycg hkedagvvcs ehqswrltgg tdrcegqvev hfrgvwntvc dsewypseak
      301 vlcqslgcgt averpkglph slsgrmyysc ngeeltlsnc swrfnnsnlc sqslaarvlc
      361 sasrslhnls tpevpasvqt vtiessvtvk ienkesrelm llipsivlgi lllgslifia
      421 fillrikgky alpvmvnhqh lpttipagsn syqpvpitip kevfmlpiqv qapppedsds
      481 gsdsdyehyd fsaqppvalt tfynsqrhrv tdeevqqsrf qmppleegle elhashipta
      541 npghcitdpp slgpqyhprs nsesstssge dycnspkskl ppwnpqvfss erssfleqpp
      601 nlelagtqpa fsgspspqpd stdnddyddi saa
//
LOCUS       XP_054226497             627 aa            linear   PRI 05-AUG-2025
DEFINITION  T-cell differentiation antigen CD6 isoform X5 [Homo sapiens].
ACCESSION   XP_054226497
VERSION     XP_054226497.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370522.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..627
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..627
                     /product="T-cell differentiation antigen CD6 isoform X5"
                     /calculated_mol_wt=67214
     Region          50..156
                     /region_name="SRCR"
                     /note="Scavenger receptor cysteine-rich domain; pfam00530"
                     /db_xref="CDD:459844"
     Region          161..260
                     /region_name="SR"
                     /note="Scavenger receptor Cys-rich; smart00202"
                     /db_xref="CDD:214555"
     Region          270..361
                     /region_name="SRCR"
                     /note="Scavenger receptor cysteine-rich domain; pfam00530"
                     /db_xref="CDD:459844"
     CDS             1..627
                     /gene="CD6"
                     /gene_synonym="TP120"
                     /coded_by="XM_054370522.1:187..2070"
                     /db_xref="GeneID:923"
                     /db_xref="HGNC:HGNC:1691"
                     /db_xref="MIM:186720"
ORIGIN      
        1 mwlffgitgl ltaalsghps pappdqlnts saeselwepg erlpvrltng ssscsgtvev
       61 rleaswepac galwdsraae avcralgcgg aeaasqlapp tpelppppaa gntsvaanat
      121 lagapallcs gaewrlcevv ehacrsdgrr arvtcaenra lrlvdgggac agrvemlehg
      181 ewgsvcddtw dledahvvcr qlgcgwavqa lpglhftpgr gpihwdqvnc sgaeaylwdc
      241 pglpgqhycg hkedagvvcs ehqswrltgg tdrcegqvev hfrgvwntvc dsewypseak
      301 vlcqslgcgt averpkglph slsgrmyysc ngeeltlsnc swrfnnsnlc sqslaarvlc
      361 sasrslhnls tpevpasvqt vtiessvtvk ienkesrelm llipsivlgi lllgslifia
      421 fillrikgky alpvmvnhqh lpttipagsn syqpvpitip kedsqrhrvt deevqqsrfq
      481 mppleeglee lhashiptan pghcitdpps lgpqyhprsn sesstssged ycnspksklp
      541 pwnpqvfsse rssfleqppn lelagtqpaf sagppaddss stssgewyqn fqpppqppse
      601 eqfgcpgsps pqpdstdndd yddisaa
//
LOCUS       XP_054226498             626 aa            linear   PRI 05-AUG-2025
DEFINITION  T-cell differentiation antigen CD6 isoform X6 [Homo sapiens].
ACCESSION   XP_054226498
VERSION     XP_054226498.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370523.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..626
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..626
                     /product="T-cell differentiation antigen CD6 isoform X6"
                     /calculated_mol_wt=67143
     Region          50..156
                     /region_name="SRCR"
                     /note="Scavenger receptor cysteine-rich domain; pfam00530"
                     /db_xref="CDD:459844"
     Region          161..260
                     /region_name="SR"
                     /note="Scavenger receptor Cys-rich; smart00202"
                     /db_xref="CDD:214555"
     Region          270..361
                     /region_name="SRCR"
                     /note="Scavenger receptor cysteine-rich domain; pfam00530"
                     /db_xref="CDD:459844"
     CDS             1..626
                     /gene="CD6"
                     /gene_synonym="TP120"
                     /coded_by="XM_054370523.1:187..2067"
                     /db_xref="GeneID:923"
                     /db_xref="HGNC:HGNC:1691"
                     /db_xref="MIM:186720"
ORIGIN      
        1 mwlffgitgl ltaalsghps pappdqlnts saeselwepg erlpvrltng ssscsgtvev
       61 rleaswepac galwdsraae avcralgcgg aeaasqlapp tpelppppaa gntsvaanat
      121 lagapallcs gaewrlcevv ehacrsdgrr arvtcaenra lrlvdgggac agrvemlehg
      181 ewgsvcddtw dledahvvcr qlgcgwavqa lpglhftpgr gpihwdqvnc sgaeaylwdc
      241 pglpgqhycg hkedagvvcs ehqswrltgg tdrcegqvev hfrgvwntvc dsewypseak
      301 vlcqslgcgt averpkglph slsgrmyysc ngeeltlsnc swrfnnsnlc sqslaarvlc
      361 sasrslhnls tpevpasvqt vtiessvtvk ienkesrelm llipsivlgi lllgslifia
      421 fillrikgky alpvmvnhqh lpttipagsn syqpvpitip kedsqrhrvt deevqqsrfq
      481 mppleeglee lhashiptan pghcitdpps lgpqyhprsn sesstssged ycnspksklp
      541 pwnpqvfsse rssfleqppn lelagtqpaf sgppaddsss tssgewyqnf qpppqppsee
      601 qfgcpgspsp qpdstdnddy ddisaa
//
LOCUS       XP_054226499             567 aa            linear   PRI 05-AUG-2025
DEFINITION  T-cell differentiation antigen CD6 isoform X7 [Homo sapiens].
ACCESSION   XP_054226499
VERSION     XP_054226499.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370524.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..567
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..567
                     /product="T-cell differentiation antigen CD6 isoform X7"
                     /calculated_mol_wt=60500
     Region          50..156
                     /region_name="SRCR"
                     /note="Scavenger receptor cysteine-rich domain; pfam00530"
                     /db_xref="CDD:459844"
     Region          161..260
                     /region_name="SR"
                     /note="Scavenger receptor Cys-rich; smart00202"
                     /db_xref="CDD:214555"
     CDS             1..567
                     /gene="CD6"
                     /gene_synonym="TP120"
                     /coded_by="XM_054370524.1:187..1890"
                     /db_xref="GeneID:923"
                     /db_xref="HGNC:HGNC:1691"
                     /db_xref="MIM:186720"
ORIGIN      
        1 mwlffgitgl ltaalsghps pappdqlnts saeselwepg erlpvrltng ssscsgtvev
       61 rleaswepac galwdsraae avcralgcgg aeaasqlapp tpelppppaa gntsvaanat
      121 lagapallcs gaewrlcevv ehacrsdgrr arvtcaenra lrlvdgggac agrvemlehg
      181 ewgsvcddtw dledahvvcr qlgcgwavqa lpglhftpgr gpihwdqvnc sgaeaylwdc
      241 pglpgqhycg hkedagvvcs asrslhnlst pevpasvqtv tiessvtvki enkesrelml
      301 lipsivlgil llgslifiaf illrikgkya lpvmvnhqhl pttipagsns yqpvpitipk
      361 evfmlpiqvq apppedsdsg sdsdyehydf saqppvaltt fynsqrhrvt deevqqsrfq
      421 mppleeglee lhashiptan pghcitdpps lgpqyhprsn sesstssged ycnspksklp
      481 pwnpqvfsse rssfleqppn lelagtqpaf sagppaddss stssgewyqn fqpppqppse
      541 eqfgcpgsps pqpdstdndd yddisaa
//
LOCUS       XP_054226500             566 aa            linear   PRI 05-AUG-2025
DEFINITION  T-cell differentiation antigen CD6 isoform X8 [Homo sapiens].
ACCESSION   XP_054226500
VERSION     XP_054226500.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370525.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..566
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..566
                     /product="T-cell differentiation antigen CD6 isoform X8"
                     /calculated_mol_wt=60429
     Region          50..156
                     /region_name="SRCR"
                     /note="Scavenger receptor cysteine-rich domain; pfam00530"
                     /db_xref="CDD:459844"
     Region          161..260
                     /region_name="SR"
                     /note="Scavenger receptor Cys-rich; smart00202"
                     /db_xref="CDD:214555"
     CDS             1..566
                     /gene="CD6"
                     /gene_synonym="TP120"
                     /coded_by="XM_054370525.1:187..1887"
                     /db_xref="GeneID:923"
                     /db_xref="HGNC:HGNC:1691"
                     /db_xref="MIM:186720"
ORIGIN      
        1 mwlffgitgl ltaalsghps pappdqlnts saeselwepg erlpvrltng ssscsgtvev
       61 rleaswepac galwdsraae avcralgcgg aeaasqlapp tpelppppaa gntsvaanat
      121 lagapallcs gaewrlcevv ehacrsdgrr arvtcaenra lrlvdgggac agrvemlehg
      181 ewgsvcddtw dledahvvcr qlgcgwavqa lpglhftpgr gpihwdqvnc sgaeaylwdc
      241 pglpgqhycg hkedagvvcs asrslhnlst pevpasvqtv tiessvtvki enkesrelml
      301 lipsivlgil llgslifiaf illrikgkya lpvmvnhqhl pttipagsns yqpvpitipk
      361 evfmlpiqvq apppedsdsg sdsdyehydf saqppvaltt fynsqrhrvt deevqqsrfq
      421 mppleeglee lhashiptan pghcitdpps lgpqyhprsn sesstssged ycnspksklp
      481 pwnpqvfsse rssfleqppn lelagtqpaf sgppaddsss tssgewyqnf qpppqppsee
      541 qfgcpgspsp qpdstdnddy ddisaa
//
LOCUS       XP_054226501             535 aa            linear   PRI 05-AUG-2025
DEFINITION  T-cell differentiation antigen CD6 isoform X9 [Homo sapiens].
ACCESSION   XP_054226501
VERSION     XP_054226501.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370526.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..535
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..535
                     /product="T-cell differentiation antigen CD6 isoform X9"
                     /calculated_mol_wt=57067
     Region          50..156
                     /region_name="SRCR"
                     /note="Scavenger receptor cysteine-rich domain; pfam00530"
                     /db_xref="CDD:459844"
     Region          161..260
                     /region_name="SR"
                     /note="Scavenger receptor Cys-rich; smart00202"
                     /db_xref="CDD:214555"
     CDS             1..535
                     /gene="CD6"
                     /gene_synonym="TP120"
                     /coded_by="XM_054370526.1:187..1794"
                     /db_xref="GeneID:923"
                     /db_xref="HGNC:HGNC:1691"
                     /db_xref="MIM:186720"
ORIGIN      
        1 mwlffgitgl ltaalsghps pappdqlnts saeselwepg erlpvrltng ssscsgtvev
       61 rleaswepac galwdsraae avcralgcgg aeaasqlapp tpelppppaa gntsvaanat
      121 lagapallcs gaewrlcevv ehacrsdgrr arvtcaenra lrlvdgggac agrvemlehg
      181 ewgsvcddtw dledahvvcr qlgcgwavqa lpglhftpgr gpihwdqvnc sgaeaylwdc
      241 pglpgqhycg hkedagvvcs asrslhnlst pevpasvqtv tiessvtvki enkesrelml
      301 lipsivlgil llgslifiaf illrikgkyv fmlpiqvqap ppedsdsgsd sdyehydfsa
      361 qppvalttfy nsqrhrvtde evqqsrfqmp pleegleelh ashiptanpg hcitdppslg
      421 pqyhprsnse sstssgedyc nspksklppw npqvfssers sfleqppnle lagtqpafsa
      481 gppaddssst ssgewyqnfq pppqppseeq fgcpgspspq pdstdnddyd disaa
//
LOCUS       XP_054226502             534 aa            linear   PRI 05-AUG-2025
DEFINITION  T-cell differentiation antigen CD6 isoform X10 [Homo sapiens].
ACCESSION   XP_054226502
VERSION     XP_054226502.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370527.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..534
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..534
                     /product="T-cell differentiation antigen CD6 isoform X10"
                     /calculated_mol_wt=56996
     Region          50..156
                     /region_name="SRCR"
                     /note="Scavenger receptor cysteine-rich domain; pfam00530"
                     /db_xref="CDD:459844"
     Region          161..260
                     /region_name="SR"
                     /note="Scavenger receptor Cys-rich; smart00202"
                     /db_xref="CDD:214555"
     CDS             1..534
                     /gene="CD6"
                     /gene_synonym="TP120"
                     /coded_by="XM_054370527.1:187..1791"
                     /db_xref="GeneID:923"
                     /db_xref="HGNC:HGNC:1691"
                     /db_xref="MIM:186720"
ORIGIN      
        1 mwlffgitgl ltaalsghps pappdqlnts saeselwepg erlpvrltng ssscsgtvev
       61 rleaswepac galwdsraae avcralgcgg aeaasqlapp tpelppppaa gntsvaanat
      121 lagapallcs gaewrlcevv ehacrsdgrr arvtcaenra lrlvdgggac agrvemlehg
      181 ewgsvcddtw dledahvvcr qlgcgwavqa lpglhftpgr gpihwdqvnc sgaeaylwdc
      241 pglpgqhycg hkedagvvcs asrslhnlst pevpasvqtv tiessvtvki enkesrelml
      301 lipsivlgil llgslifiaf illrikgkyv fmlpiqvqap ppedsdsgsd sdyehydfsa
      361 qppvalttfy nsqrhrvtde evqqsrfqmp pleegleelh ashiptanpg hcitdppslg
      421 pqyhprsnse sstssgedyc nspksklppw npqvfssers sfleqppnle lagtqpafsg
      481 ppaddsssts sgewyqnfqp ppqppseeqf gcpgspspqp dstdnddydd isaa
//
LOCUS       XP_054226503             532 aa            linear   PRI 05-AUG-2025
DEFINITION  T-cell differentiation antigen CD6 isoform X11 [Homo sapiens].
ACCESSION   XP_054226503
VERSION     XP_054226503.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370528.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..532
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..532
                     /product="T-cell differentiation antigen CD6 isoform X11"
                     /calculated_mol_wt=56795
     Region          50..156
                     /region_name="SRCR"
                     /note="Scavenger receptor cysteine-rich domain; pfam00530"
                     /db_xref="CDD:459844"
     Region          161..260
                     /region_name="SR"
                     /note="Scavenger receptor Cys-rich; smart00202"
                     /db_xref="CDD:214555"
     CDS             1..532
                     /gene="CD6"
                     /gene_synonym="TP120"
                     /coded_by="XM_054370528.1:187..1785"
                     /db_xref="GeneID:923"
                     /db_xref="HGNC:HGNC:1691"
                     /db_xref="MIM:186720"
ORIGIN      
        1 mwlffgitgl ltaalsghps pappdqlnts saeselwepg erlpvrltng ssscsgtvev
       61 rleaswepac galwdsraae avcralgcgg aeaasqlapp tpelppppaa gntsvaanat
      121 lagapallcs gaewrlcevv ehacrsdgrr arvtcaenra lrlvdgggac agrvemlehg
      181 ewgsvcddtw dledahvvcr qlgcgwavqa lpglhftpgr gpihwdqvnc sgaeaylwdc
      241 pglpgqhycg hkedagvvcs asrslhnlst pevpasvqtv tiessvtvki enkesrelml
      301 lipsivlgil llgslifiaf illrikgkya lpvmvnhqhl pttipagsns yqpvpitipk
      361 evfmlpiqvq apppedsdsg sdsdyehydf saqppvaltt fynsqrhrvt deevqqsrfq
      421 mppleeglee lhashiptan pghcitdpps lgpqyhprsn sesstssged ycnspksklp
      481 pwnpqvfsse rssfleqppn lelagtqpaf sgspspqpds tdnddyddis aa
//
LOCUS       XP_054226504             526 aa            linear   PRI 05-AUG-2025
DEFINITION  T-cell differentiation antigen CD6 isoform X12 [Homo sapiens].
ACCESSION   XP_054226504
VERSION     XP_054226504.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370529.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..526
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..526
                     /product="T-cell differentiation antigen CD6 isoform X12"
                     /calculated_mol_wt=55956
     Region          50..156
                     /region_name="SRCR"
                     /note="Scavenger receptor cysteine-rich domain; pfam00530"
                     /db_xref="CDD:459844"
     Region          161..260
                     /region_name="SR"
                     /note="Scavenger receptor Cys-rich; smart00202"
                     /db_xref="CDD:214555"
     CDS             1..526
                     /gene="CD6"
                     /gene_synonym="TP120"
                     /coded_by="XM_054370529.1:187..1767"
                     /db_xref="GeneID:923"
                     /db_xref="HGNC:HGNC:1691"
                     /db_xref="MIM:186720"
ORIGIN      
        1 mwlffgitgl ltaalsghps pappdqlnts saeselwepg erlpvrltng ssscsgtvev
       61 rleaswepac galwdsraae avcralgcgg aeaasqlapp tpelppppaa gntsvaanat
      121 lagapallcs gaewrlcevv ehacrsdgrr arvtcaenra lrlvdgggac agrvemlehg
      181 ewgsvcddtw dledahvvcr qlgcgwavqa lpglhftpgr gpihwdqvnc sgaeaylwdc
      241 pglpgqhycg hkedagvvcs asrslhnlst pevpasvqtv tiessvtvki enkesrelml
      301 lipsivlgil llgslifiaf illrikgkya lpvmvnhqhl pttipagsns yqpvpitipk
      361 edsqrhrvtd eevqqsrfqm ppleegleel hashiptanp ghcitdppsl gpqyhprsns
      421 esstssgedy cnspksklpp wnpqvfsser ssfleqppnl elagtqpafs agppaddsss
      481 tssgewyqnf qpppqppsee qfgcpgspsp qpdstdnddy ddisaa
//
LOCUS       XP_054226505             154 aa            linear   PRI 05-AUG-2025
DEFINITION  membrane-spanning 4-domains subfamily A member 3 isoform X1 [Homo
            sapiens].
ACCESSION   XP_054226505
VERSION     XP_054226505.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370530.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..154
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..154
                     /product="membrane-spanning 4-domains subfamily A member 3
                     isoform X1"
                     /calculated_mol_wt=16670
     Region          1..136
                     /region_name="CD20"
                     /note="CD20-like family; pfam04103"
                     /db_xref="CDD:461174"
     CDS             1..154
                     /gene="MS4A3"
                     /gene_synonym="CD20L; HTM4"
                     /coded_by="XM_054370530.1:56..520"
                     /db_xref="GeneID:932"
                     /db_xref="HGNC:HGNC:7317"
                     /db_xref="MIM:606498"
ORIGIN      
        1 milalgvflg slqypyhfqk hfffftfytg ypiwgavffc ssgtlsvvag ikptrtwiqn
       61 sfgmniasat ialvgtafls lniavniqsl rschsssesp dlcnymgsis ngmvslllil
      121 tllelcvtis tiamwcnanc cnsreeissp pnsv
//
LOCUS       XP_054226506             551 aa            linear   PRI 05-AUG-2025
DEFINITION  solute carrier family 22 member 6 isoform X1 [Homo sapiens].
ACCESSION   XP_054226506
VERSION     XP_054226506.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370531.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..551
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..551
                     /product="solute carrier family 22 member 6 isoform X1"
                     /calculated_mol_wt=60315
     Region          11..516
                     /region_name="2A0119"
                     /note="cation transport protein; TIGR00898"
                     /db_xref="CDD:273328"
     CDS             1..551
                     /gene="SLC22A6"
                     /gene_synonym="HOAT1; OAT1; PAHT; ROAT1"
                     /coded_by="XM_054370531.1:278..1933"
                     /db_xref="GeneID:9356"
                     /db_xref="HGNC:HGNC:10970"
                     /db_xref="MIM:607582"
ORIGIN      
        1 mafndllqqv ggvgrfqqiq vtlvvlplll mashntlqnf taaipthhcr ppadanlskn
       61 gglevwlprd rqgqpesclr ftspqwglpf lngteangtg atepctdgwi ydnstfpsti
      121 vtewdlvcsh ralrqlaqsl ymvgvllgam vfgyladrlg rrkvlilnyl qtavsgtcaa
      181 fapnfpiyca frllsgmala gislncmtln vewmpihtra cvgtligyvy slgqfllagv
      241 ayavphwrhl qllvsapffa ffiyswffie sarwhsssgr ldltlralqr varingkree
      301 gaklsmeqvl raslqkeltm gkgqasamel lrcptlrhlf lclsmlwfat sfayyglvmd
      361 lqgfgvsiyl iqvifgavdl paklvgflvi nslgrrpaqm aalllagici llngvipqdq
      421 sivrtslavl gkgclaasfn ciflytgely ptmirqtgmg mgstmarvgs ivsplvsmta
      481 elypsmplfi ygavpvaasa vtvllpetlg qplpdtvqdl esrkgkqtrq qqehqkymvp
      541 lqasaqekng l
//
LOCUS       XP_054226507             466 aa            linear   PRI 05-AUG-2025
DEFINITION  organic anion transporter 3 isoform X1 [Homo sapiens].
ACCESSION   XP_054226507
VERSION     XP_054226507.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370532.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..466
                     /product="organic anion transporter 3 isoform X1"
                     /calculated_mol_wt=51149
     Region          35..417
                     /region_name="MFS"
                     /note="Major Facilitator Superfamily; cl28910"
                     /db_xref="CDD:475125"
     Site            order(37,61,111..112,114..116,119,135,138..139,142,258,
                     261..262,265..267,270,290,294,345..346,350,354,370,
                     373..374,377..378,381)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:349949"
     CDS             1..466
                     /gene="SLC22A8"
                     /gene_synonym="OAT3"
                     /coded_by="XM_054370532.1:667..2067"
                     /db_xref="GeneID:9376"
                     /db_xref="HGNC:HGNC:10972"
                     /db_xref="MIM:607581"
ORIGIN      
        1 mtghtclrda gqgpkshrqt qgapsraekg ngpwewdlvc nsnklkemaq sifmagilig
       61 glvlgdlsdr fgrrpiltcs ylllaasgsg aafsptfpiy mvfrflcgfg isgitlstvi
      121 lnvewvptrm raimstalgy cytfgqfilp glayaipqwr wlqltvsipf fvfflsswwt
      181 pesirwlvls gksskalkil rrvavfngkk eegerlslee lklnlqkeis lakakytasd
      241 lfripmlrrm tfclslawfa tgfayyslam gveefgvnly ilqiifggvd vpakfitils
      301 lsylgrhttq aaalllagga ilaltfvpld lqtvrtvlav fgkgclsssf sclflytsel
      361 yptvirqtgm gvsnlwtrvg smvsplvkit gevqpfipni iygitallgg saalflpetl
      421 nqplpetied lenwslrakk pkqepeveka sqriplqphg pglgss
//
LOCUS       XP_054226508             366 aa            linear   PRI 05-AUG-2025
DEFINITION  leupaxin isoform X1 [Homo sapiens].
ACCESSION   XP_054226508
VERSION     XP_054226508.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370533.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..366
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..366
                     /product="leupaxin isoform X1"
                     /calculated_mol_wt=41512
     Region          130..184
                     /region_name="LIM1_Leupaxin"
                     /note="The first LIM domain of Leupaxin; cd09406"
                     /db_xref="CDD:188790"
     Site            order(132,135,152,155,158,161,179,182)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:188790"
     Region          191..242
                     /region_name="LIM"
                     /note="LIM is a small protein-protein interaction domain,
                     containing two zinc fingers; cl02475"
                     /db_xref="CDD:413332"
     Site            order(191,194,211,214,217,220,238,241)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     Region          250..302
                     /region_name="LIM3_Leupaxin"
                     /note="The third LIM domain of Leupaxin; cd09410"
                     /db_xref="CDD:188794"
     Site            order(250,253,270,273,276,279,297,300)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:188794"
     Region          309..360
                     /region_name="LIM4_Paxillin_like"
                     /note="The fourth LIM domain of the Paxillin-like protein
                     family; cd09339"
                     /db_xref="CDD:188725"
     Site            order(309,312,329,332,335,338,356,359)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:188725"
     CDS             1..366
                     /gene="LPXN"
                     /gene_synonym="LDPL"
                     /coded_by="XM_054370533.1:1533..2633"
                     /db_xref="GeneID:9404"
                     /db_xref="HGNC:HGNC:14061"
                     /db_xref="MIM:605390"
ORIGIN      
        1 mpywrnwnap pfrtvmnipt qllfpwisip errltlmrlr rsflfritqv pcreaqepke
       61 spppsktsaa aqldelmahl temqakvavr adagkkhlpd kqdhkaslds mlggleqelq
      121 dlgiatvpkg hcascqkpia gkvihalgqs whpehfvcth ckeeigsspf fersglaycp
      181 ndyhqlfspr caycaapild kvltamnqtw hpehffcshc gevfgaegfh ekdkkpycrk
      241 dflamfspkc ggcnrpvlen ylsamdtvwh pecfvcgdcf tsfstgsffe ldgrpfcelh
      301 yhhrrgtlch gcgqpitgrc isamgykfhp ehfvcafclt qlskgifreq ndktycqpcf
      361 nklfpl
//
LOCUS       XP_054226509             366 aa            linear   PRI 05-AUG-2025
DEFINITION  leupaxin isoform X1 [Homo sapiens].
ACCESSION   XP_054226509
VERSION     XP_054226509.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370534.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..366
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..366
                     /product="leupaxin isoform X1"
                     /calculated_mol_wt=41512
     Region          130..184
                     /region_name="LIM1_Leupaxin"
                     /note="The first LIM domain of Leupaxin; cd09406"
                     /db_xref="CDD:188790"
     Site            order(132,135,152,155,158,161,179,182)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:188790"
     Region          191..242
                     /region_name="LIM"
                     /note="LIM is a small protein-protein interaction domain,
                     containing two zinc fingers; cl02475"
                     /db_xref="CDD:413332"
     Site            order(191,194,211,214,217,220,238,241)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     Region          250..302
                     /region_name="LIM3_Leupaxin"
                     /note="The third LIM domain of Leupaxin; cd09410"
                     /db_xref="CDD:188794"
     Site            order(250,253,270,273,276,279,297,300)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:188794"
     Region          309..360
                     /region_name="LIM4_Paxillin_like"
                     /note="The fourth LIM domain of the Paxillin-like protein
                     family; cd09339"
                     /db_xref="CDD:188725"
     Site            order(309,312,329,332,335,338,356,359)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:188725"
     CDS             1..366
                     /gene="LPXN"
                     /gene_synonym="LDPL"
                     /coded_by="XM_054370534.1:85..1185"
                     /db_xref="GeneID:9404"
                     /db_xref="HGNC:HGNC:14061"
                     /db_xref="MIM:605390"
ORIGIN      
        1 mpywrnwnap pfrtvmnipt qllfpwisip errltlmrlr rsflfritqv pcreaqepke
       61 spppsktsaa aqldelmahl temqakvavr adagkkhlpd kqdhkaslds mlggleqelq
      121 dlgiatvpkg hcascqkpia gkvihalgqs whpehfvcth ckeeigsspf fersglaycp
      181 ndyhqlfspr caycaapild kvltamnqtw hpehffcshc gevfgaegfh ekdkkpycrk
      241 dflamfspkc ggcnrpvlen ylsamdtvwh pecfvcgdcf tsfstgsffe ldgrpfcelh
      301 yhhrrgtlch gcgqpitgrc isamgykfhp ehfvcafclt qlskgifreq ndktycqpcf
      361 nklfpl
//
LOCUS       XP_054226510             283 aa            linear   PRI 05-AUG-2025
DEFINITION  leupaxin isoform X2 [Homo sapiens].
ACCESSION   XP_054226510
VERSION     XP_054226510.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370535.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..283
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..283
                     /product="leupaxin isoform X2"
                     /calculated_mol_wt=31129
     Region          155..209
                     /region_name="LIM1_Leupaxin"
                     /note="The first LIM domain of Leupaxin; cd09406"
                     /db_xref="CDD:188790"
     Site            order(157,160,177,180,183,186,204,207)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:188790"
     Region          216..>252
                     /region_name="LIM"
                     /note="LIM is a small protein-protein interaction domain,
                     containing two zinc fingers; cl02475"
                     /db_xref="CDD:413332"
     CDS             1..283
                     /gene="LPXN"
                     /gene_synonym="LDPL"
                     /coded_by="XM_054370535.1:88..939"
                     /db_xref="GeneID:9404"
                     /db_xref="HGNC:HGNC:14061"
                     /db_xref="MIM:605390"
ORIGIN      
        1 mstllisssd alleelerst lqdsdeysnp aplpldqhsr ketnldetse ilsiqdntsp
       61 lpaqlvyttn iqelnvysea qepkesppps ktsaaaqlde lmahltemqa kvavradagk
      121 khlpdkqdhk asldsmlggl eqelqdlgia tvpkghcasc qkpiagkvih algqswhpeh
      181 fvcthckeei gsspffersg laycpndyhq lfsprcayca apildkvlta mnqtwhpehf
      241 fcshcgevfg aeemacpekr nlerqsshss laelrlapps lif
//
LOCUS       XP_054226511             278 aa            linear   PRI 05-AUG-2025
DEFINITION  leupaxin isoform X3 [Homo sapiens].
ACCESSION   XP_054226511
VERSION     XP_054226511.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370536.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..278
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..278
                     /product="leupaxin isoform X3"
                     /calculated_mol_wt=30712
     Region          150..204
                     /region_name="LIM1_Leupaxin"
                     /note="The first LIM domain of Leupaxin; cd09406"
                     /db_xref="CDD:188790"
     Site            order(152,155,172,175,178,181,199,202)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:188790"
     Region          211..>247
                     /region_name="LIM"
                     /note="LIM is a small protein-protein interaction domain,
                     containing two zinc fingers; cl02475"
                     /db_xref="CDD:413332"
     CDS             1..278
                     /gene="LPXN"
                     /gene_synonym="LDPL"
                     /coded_by="XM_054370536.1:85..921"
                     /db_xref="GeneID:9404"
                     /db_xref="HGNC:HGNC:14061"
                     /db_xref="MIM:605390"
ORIGIN      
        1 meeldallee lerstlqdsd eysnpaplpl dqhsrketnl detseilsiq dntsplpaql
       61 vyttniqeln vyseaqepke spppsktsaa aqldelmahl temqakvavr adagkkhlpd
      121 kqdhkaslds mlggleqelq dlgiatvpkg hcascqkpia gkvihalgqs whpehfvcth
      181 ckeeigsspf fersglaycp ndyhqlfspr caycaapild kvltamnqtw hpehffcshc
      241 gevfgaeema cpekrnlerq sshsslaelr lappslif
//
LOCUS       XP_054226512             254 aa            linear   PRI 05-AUG-2025
DEFINITION  leupaxin isoform X4 [Homo sapiens].
ACCESSION   XP_054226512
VERSION     XP_054226512.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370537.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..254
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..254
                     /product="leupaxin isoform X4"
                     /calculated_mol_wt=27898
     Region          155..209
                     /region_name="LIM1_Leupaxin"
                     /note="The first LIM domain of Leupaxin; cd09406"
                     /db_xref="CDD:188790"
     Site            order(157,160,177,180,183,186,204,207)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:188790"
     Region          216..>254
                     /region_name="LIM"
                     /note="LIM is a small protein-protein interaction domain,
                     containing two zinc fingers; cl02475"
                     /db_xref="CDD:413332"
     CDS             1..254
                     /gene="LPXN"
                     /gene_synonym="LDPL"
                     /coded_by="XM_054370537.1:88..852"
                     /db_xref="GeneID:9404"
                     /db_xref="HGNC:HGNC:14061"
                     /db_xref="MIM:605390"
ORIGIN      
        1 mstllisssd alleelerst lqdsdeysnp aplpldqhsr ketnldetse ilsiqdntsp
       61 lpaqlvyttn iqelnvysea qepkesppps ktsaaaqlde lmahltemqa kvavradagk
      121 khlpdkqdhk asldsmlggl eqelqdlgia tvpkghcasc qkpiagkvih algqswhpeh
      181 fvcthckeei gsspffersg laycpndyhq lfsprcayca apildkvlta mnqtwhpehf
      241 fcshcgevfg aedf
//
LOCUS       XP_054226513             249 aa            linear   PRI 05-AUG-2025
DEFINITION  leupaxin isoform X5 [Homo sapiens].
ACCESSION   XP_054226513
VERSION     XP_054226513.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370538.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..249
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..249
                     /product="leupaxin isoform X5"
                     /calculated_mol_wt=27481
     Region          150..204
                     /region_name="LIM1_Leupaxin"
                     /note="The first LIM domain of Leupaxin; cd09406"
                     /db_xref="CDD:188790"
     Site            order(152,155,172,175,178,181,199,202)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:188790"
     Region          211..>249
                     /region_name="LIM"
                     /note="LIM is a small protein-protein interaction domain,
                     containing two zinc fingers; cl02475"
                     /db_xref="CDD:413332"
     CDS             1..249
                     /gene="LPXN"
                     /gene_synonym="LDPL"
                     /coded_by="XM_054370538.1:85..834"
                     /db_xref="GeneID:9404"
                     /db_xref="HGNC:HGNC:14061"
                     /db_xref="MIM:605390"
ORIGIN      
        1 meeldallee lerstlqdsd eysnpaplpl dqhsrketnl detseilsiq dntsplpaql
       61 vyttniqeln vyseaqepke spppsktsaa aqldelmahl temqakvavr adagkkhlpd
      121 kqdhkaslds mlggleqelq dlgiatvpkg hcascqkpia gkvihalgqs whpehfvcth
      181 ckeeigsspf fersglaycp ndyhqlfspr caycaapild kvltamnqtw hpehffcshc
      241 gevfgaedf
//
LOCUS       XP_054226514             194 aa            linear   PRI 05-AUG-2025
DEFINITION  leupaxin isoform X6 [Homo sapiens].
ACCESSION   XP_054226514
VERSION     XP_054226514.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370539.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..194
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..194
                     /product="leupaxin isoform X6"
                     /calculated_mol_wt=21045
     Region          155..>167
                     /region_name="LIM"
                     /note="LIM is a small protein-protein interaction domain,
                     containing two zinc fingers; cl02475"
                     /db_xref="CDD:413332"
     CDS             1..194
                     /gene="LPXN"
                     /gene_synonym="LDPL"
                     /coded_by="XM_054370539.1:88..672"
                     /db_xref="GeneID:9404"
                     /db_xref="HGNC:HGNC:14061"
                     /db_xref="MIM:605390"
ORIGIN      
        1 mstllisssd alleelerst lqdsdeysnp aplpldqhsr ketnldetse ilsiqdntsp
       61 lpaqlvyttn iqelnvysea qepkesppps ktsaaaqlde lmahltemqa kvavradagk
      121 khlpdkqdhk asldsmlggl eqelqdlgia tvpkghcasc qkpiagkpfk kndcslckde
      181 etedsetlmd iska
//
LOCUS       XP_054226515             189 aa            linear   PRI 05-AUG-2025
DEFINITION  leupaxin isoform X7 [Homo sapiens].
ACCESSION   XP_054226515
VERSION     XP_054226515.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370540.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..189
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..189
                     /product="leupaxin isoform X7"
                     /calculated_mol_wt=20627
     Region          150..>162
                     /region_name="LIM"
                     /note="LIM is a small protein-protein interaction domain,
                     containing two zinc fingers; cl02475"
                     /db_xref="CDD:413332"
     CDS             1..189
                     /gene="LPXN"
                     /gene_synonym="LDPL"
                     /coded_by="XM_054370540.1:85..654"
                     /db_xref="GeneID:9404"
                     /db_xref="HGNC:HGNC:14061"
                     /db_xref="MIM:605390"
ORIGIN      
        1 meeldallee lerstlqdsd eysnpaplpl dqhsrketnl detseilsiq dntsplpaql
       61 vyttniqeln vyseaqepke spppsktsaa aqldelmahl temqakvavr adagkkhlpd
      121 kqdhkaslds mlggleqelq dlgiatvpkg hcascqkpia gkpfkkndcs lckdeeteds
      181 etlmdiska
//
LOCUS       XP_054226516             295 aa            linear   PRI 05-AUG-2025
DEFINITION  peroxisomal biogenesis factor 16 isoform X1 [Homo sapiens].
ACCESSION   XP_054226516
VERSION     XP_054226516.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370541.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 13% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..295
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..295
                     /product="peroxisomal biogenesis factor 16 isoform X1"
                     /calculated_mol_wt=33959
     Region          9..288
                     /region_name="Pex16"
                     /note="Peroxisomal membrane protein (Pex16); pfam08610"
                     /db_xref="CDD:462535"
     CDS             1..295
                     /gene="PEX16"
                     /gene_synonym="PBD8A; PBD8B"
                     /coded_by="XM_054370541.1:358..1245"
                     /db_xref="GeneID:9409"
                     /db_xref="HGNC:HGNC:8857"
                     /db_xref="MIM:603360"
ORIGIN      
        1 mhwvlksrvy sasnllvlln dgilrkelrk klpvslsqqk lltwlsvlec vevfmemgaa
       61 kvwgevgrwl vialiqlaka vlrmllllwf kaglqtsppi vpldretqaq ppdgdhspgn
      121 heqsyvgkrs nrvvrtlqnt pslhsrhwga pqqregrqqq hheelsatpt plglqetiae
      181 flyiarpllh llslglwgqr swkpwllagv vdvtslslls drkgltrrer relrrrtill
      241 lyyllrspfy drfsearilf llqlladhvp gvglvtrplm dylptwqkiy fyswg
//
LOCUS       XP_054226517             241 aa            linear   PRI 05-AUG-2025
DEFINITION  peroxisomal biogenesis factor 16 isoform X2 [Homo sapiens].
ACCESSION   XP_054226517
VERSION     XP_054226517.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370542.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..241
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..241
                     /product="peroxisomal biogenesis factor 16 isoform X2"
                     /calculated_mol_wt=27681
     Region          <1..234
                     /region_name="Pex16"
                     /note="Peroxisomal membrane protein (Pex16); pfam08610"
                     /db_xref="CDD:462535"
     CDS             1..241
                     /gene="PEX16"
                     /gene_synonym="PBD8A; PBD8B"
                     /coded_by="XM_054370542.1:870..1595"
                     /db_xref="GeneID:9409"
                     /db_xref="HGNC:HGNC:8857"
                     /db_xref="MIM:603360"
ORIGIN      
        1 memgaakvwg evgrwlvial iqlakavlrm llllwfkagl qtsppivpld retqaqppdg
       61 dhspgnheqs yvgkrsnrvv rtlqntpslh srhwgapqqr egrqqqhhee lsatptplgl
      121 qetiaeflyi arpllhllsl glwgqrswkp wllagvvdvt slsllsdrkg ltrrerrelr
      181 rrtilllyyl lrspfydrfs earilfllql ladhvpgvgl vtrplmdylp twqkiyfysw
      241 g
//
LOCUS       XP_054226518             444 aa            linear   PRI 05-AUG-2025
DEFINITION  acyl-CoA 6-desaturase isoform X1 [Homo sapiens].
ACCESSION   XP_054226518
VERSION     XP_054226518.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370543.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 10% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..444
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..444
                     /product="acyl-CoA 6-desaturase isoform X1"
                     /calculated_mol_wt=52128
     Region          1..432
                     /region_name="PLN03199"
                     /note="delta6-acyl-lipid desaturase-like protein;
                     Provisional"
                     /db_xref="CDD:178740"
     Region          162..412
                     /region_name="Delta6-FADS-like"
                     /note="The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like
                     CD includes the integral-membrane enzymes: delta-4,
                     delta-5, delta-6, delta-8, delta-8-sphingolipid, and
                     delta-11 desaturases found in vertebrates, higher plants,
                     fungi, and bacteria. These desaturases...; cd03506"
                     /db_xref="CDD:239583"
     Site            order(180,184,217,220..221,382,385..386)
                     /site_type="other"
                     /note="putative di-iron ligands [ion binding]"
                     /db_xref="CDD:239583"
     CDS             1..444
                     /gene="FADS2"
                     /gene_synonym="D6D; DES6; FADSD6; LLCDL2; SLL0262; TU13"
                     /coded_by="XM_054370543.1:2584..3918"
                     /db_xref="GeneID:9415"
                     /db_xref="HGNC:HGNC:3575"
                     /db_xref="MIM:606149"
ORIGIN      
        1 mgkggnqgeg aaerevsvpt fsweeiqkhn lrtdrwlvid rkvynitkws iqhpggqrvi
       61 ghyagedatd afrafhpdle fvgkflkpll igelapeeps qdhgknskit edfralrkta
      121 edmnlfktnh vffllllahi ialesiawft vfyfgngwip tlitafvlat sqaqagwlqh
      181 dyghlsvyrk pkwnhlvhkf vighlkgasa nwwnhrhfqh hakpnifhkd pdvnmlhvfv
      241 lgewqpieyg kkklkylpyn hqheyfflig ppllipmyfq yqiimtmivh knwvdlawav
      301 syyirffity ipfygilgal lflnfirfle shwfvwvtqm nhivmeidqe ayrdwfssql
      361 tatcnveqsf fndwfsghln fqiehhlfpt mprhnlhkia plvkslcakh gieyqekpll
      421 ralldiirsl kksgklwlda ylhk
//
LOCUS       XP_054226519             189 aa            linear   PRI 05-AUG-2025
DEFINITION  tumor protein p53-inducible protein 11 isoform X1 [Homo sapiens].
ACCESSION   XP_054226519
VERSION     XP_054226519.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370544.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..189
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..189
                     /product="tumor protein p53-inducible protein 11 isoform
                     X1"
                     /calculated_mol_wt=20923
     Region          10..188
                     /region_name="p53-inducible11"
                     /note="Tumour protein p53-inducible protein 11; pfam14936"
                     /db_xref="CDD:464386"
     CDS             1..189
                     /gene="TP53I11"
                     /gene_synonym="PIG11"
                     /coded_by="XM_054370544.1:402..971"
                     /db_xref="GeneID:9537"
                     /db_xref="HGNC:HGNC:16842"
                     /db_xref="MIM:617867"
ORIGIN      
        1 maakqppplm kkhsqtdlvs rlktrkilgv ggedddgevh rskisqvlgn eikftirepl
       61 glrvwqfvsa vlfsgiaima lafpdqlyda vfdgaqvtsk tpirlyggal lsislimwna
      121 lytaekviir wtllteacyf gvqflvvtat laetglmslg illllvsrll fvvisiyyyy
      181 qvgrrpkka
//
LOCUS       XP_054226520             189 aa            linear   PRI 05-AUG-2025
DEFINITION  tumor protein p53-inducible protein 11 isoform X1 [Homo sapiens].
ACCESSION   XP_054226520
VERSION     XP_054226520.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370545.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..189
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..189
                     /product="tumor protein p53-inducible protein 11 isoform
                     X1"
                     /calculated_mol_wt=20923
     Region          10..188
                     /region_name="p53-inducible11"
                     /note="Tumour protein p53-inducible protein 11; pfam14936"
                     /db_xref="CDD:464386"
     CDS             1..189
                     /gene="TP53I11"
                     /gene_synonym="PIG11"
                     /coded_by="XM_054370545.1:220..789"
                     /db_xref="GeneID:9537"
                     /db_xref="HGNC:HGNC:16842"
                     /db_xref="MIM:617867"
ORIGIN      
        1 maakqppplm kkhsqtdlvs rlktrkilgv ggedddgevh rskisqvlgn eikftirepl
       61 glrvwqfvsa vlfsgiaima lafpdqlyda vfdgaqvtsk tpirlyggal lsislimwna
      121 lytaekviir wtllteacyf gvqflvvtat laetglmslg illllvsrll fvvisiyyyy
      181 qvgrrpkka
//
LOCUS       XP_054226521             189 aa            linear   PRI 05-AUG-2025
DEFINITION  tumor protein p53-inducible protein 11 isoform X1 [Homo sapiens].
ACCESSION   XP_054226521
VERSION     XP_054226521.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370546.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..189
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..189
                     /product="tumor protein p53-inducible protein 11 isoform
                     X1"
                     /calculated_mol_wt=20923
     Region          10..188
                     /region_name="p53-inducible11"
                     /note="Tumour protein p53-inducible protein 11; pfam14936"
                     /db_xref="CDD:464386"
     CDS             1..189
                     /gene="TP53I11"
                     /gene_synonym="PIG11"
                     /coded_by="XM_054370546.1:275..844"
                     /db_xref="GeneID:9537"
                     /db_xref="HGNC:HGNC:16842"
                     /db_xref="MIM:617867"
ORIGIN      
        1 maakqppplm kkhsqtdlvs rlktrkilgv ggedddgevh rskisqvlgn eikftirepl
       61 glrvwqfvsa vlfsgiaima lafpdqlyda vfdgaqvtsk tpirlyggal lsislimwna
      121 lytaekviir wtllteacyf gvqflvvtat laetglmslg illllvsrll fvvisiyyyy
      181 qvgrrpkka
//
LOCUS       XP_054226522             189 aa            linear   PRI 05-AUG-2025
DEFINITION  tumor protein p53-inducible protein 11 isoform X1 [Homo sapiens].
ACCESSION   XP_054226522
VERSION     XP_054226522.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370547.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..189
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..189
                     /product="tumor protein p53-inducible protein 11 isoform
                     X1"
                     /calculated_mol_wt=20923
     Region          10..188
                     /region_name="p53-inducible11"
                     /note="Tumour protein p53-inducible protein 11; pfam14936"
                     /db_xref="CDD:464386"
     CDS             1..189
                     /gene="TP53I11"
                     /gene_synonym="PIG11"
                     /coded_by="XM_054370547.1:483..1052"
                     /db_xref="GeneID:9537"
                     /db_xref="HGNC:HGNC:16842"
                     /db_xref="MIM:617867"
ORIGIN      
        1 maakqppplm kkhsqtdlvs rlktrkilgv ggedddgevh rskisqvlgn eikftirepl
       61 glrvwqfvsa vlfsgiaima lafpdqlyda vfdgaqvtsk tpirlyggal lsislimwna
      121 lytaekviir wtllteacyf gvqflvvtat laetglmslg illllvsrll fvvisiyyyy
      181 qvgrrpkka
//
LOCUS       XP_054226523             189 aa            linear   PRI 05-AUG-2025
DEFINITION  tumor protein p53-inducible protein 11 isoform X1 [Homo sapiens].
ACCESSION   XP_054226523
VERSION     XP_054226523.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370548.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..189
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..189
                     /product="tumor protein p53-inducible protein 11 isoform
                     X1"
                     /calculated_mol_wt=20923
     Region          10..188
                     /region_name="p53-inducible11"
                     /note="Tumour protein p53-inducible protein 11; pfam14936"
                     /db_xref="CDD:464386"
     CDS             1..189
                     /gene="TP53I11"
                     /gene_synonym="PIG11"
                     /coded_by="XM_054370548.1:304..873"
                     /db_xref="GeneID:9537"
                     /db_xref="HGNC:HGNC:16842"
                     /db_xref="MIM:617867"
ORIGIN      
        1 maakqppplm kkhsqtdlvs rlktrkilgv ggedddgevh rskisqvlgn eikftirepl
       61 glrvwqfvsa vlfsgiaima lafpdqlyda vfdgaqvtsk tpirlyggal lsislimwna
      121 lytaekviir wtllteacyf gvqflvvtat laetglmslg illllvsrll fvvisiyyyy
      181 qvgrrpkka
//
LOCUS       XP_054226524             189 aa            linear   PRI 05-AUG-2025
DEFINITION  tumor protein p53-inducible protein 11 isoform X1 [Homo sapiens].
ACCESSION   XP_054226524
VERSION     XP_054226524.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370549.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..189
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..189
                     /product="tumor protein p53-inducible protein 11 isoform
                     X1"
                     /calculated_mol_wt=20923
     Region          10..188
                     /region_name="p53-inducible11"
                     /note="Tumour protein p53-inducible protein 11; pfam14936"
                     /db_xref="CDD:464386"
     CDS             1..189
                     /gene="TP53I11"
                     /gene_synonym="PIG11"
                     /coded_by="XM_054370549.1:388..957"
                     /db_xref="GeneID:9537"
                     /db_xref="HGNC:HGNC:16842"
                     /db_xref="MIM:617867"
ORIGIN      
        1 maakqppplm kkhsqtdlvs rlktrkilgv ggedddgevh rskisqvlgn eikftirepl
       61 glrvwqfvsa vlfsgiaima lafpdqlyda vfdgaqvtsk tpirlyggal lsislimwna
      121 lytaekviir wtllteacyf gvqflvvtat laetglmslg illllvsrll fvvisiyyyy
      181 qvgrrpkka
//
LOCUS       XP_054226525             189 aa            linear   PRI 05-AUG-2025
DEFINITION  tumor protein p53-inducible protein 11 isoform X1 [Homo sapiens].
ACCESSION   XP_054226525
VERSION     XP_054226525.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370550.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..189
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..189
                     /product="tumor protein p53-inducible protein 11 isoform
                     X1"
                     /calculated_mol_wt=20923
     Region          10..188
                     /region_name="p53-inducible11"
                     /note="Tumour protein p53-inducible protein 11; pfam14936"
                     /db_xref="CDD:464386"
     CDS             1..189
                     /gene="TP53I11"
                     /gene_synonym="PIG11"
                     /coded_by="XM_054370550.1:630..1199"
                     /db_xref="GeneID:9537"
                     /db_xref="HGNC:HGNC:16842"
                     /db_xref="MIM:617867"
ORIGIN      
        1 maakqppplm kkhsqtdlvs rlktrkilgv ggedddgevh rskisqvlgn eikftirepl
       61 glrvwqfvsa vlfsgiaima lafpdqlyda vfdgaqvtsk tpirlyggal lsislimwna
      121 lytaekviir wtllteacyf gvqflvvtat laetglmslg illllvsrll fvvisiyyyy
      181 qvgrrpkka
//
LOCUS       XP_054226526             189 aa            linear   PRI 05-AUG-2025
DEFINITION  tumor protein p53-inducible protein 11 isoform X1 [Homo sapiens].
ACCESSION   XP_054226526
VERSION     XP_054226526.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370551.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..189
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..189
                     /product="tumor protein p53-inducible protein 11 isoform
                     X1"
                     /calculated_mol_wt=20923
     Region          10..188
                     /region_name="p53-inducible11"
                     /note="Tumour protein p53-inducible protein 11; pfam14936"
                     /db_xref="CDD:464386"
     CDS             1..189
                     /gene="TP53I11"
                     /gene_synonym="PIG11"
                     /coded_by="XM_054370551.1:350..919"
                     /db_xref="GeneID:9537"
                     /db_xref="HGNC:HGNC:16842"
                     /db_xref="MIM:617867"
ORIGIN      
        1 maakqppplm kkhsqtdlvs rlktrkilgv ggedddgevh rskisqvlgn eikftirepl
       61 glrvwqfvsa vlfsgiaima lafpdqlyda vfdgaqvtsk tpirlyggal lsislimwna
      121 lytaekviir wtllteacyf gvqflvvtat laetglmslg illllvsrll fvvisiyyyy
      181 qvgrrpkka
//
LOCUS       XP_054226527             189 aa            linear   PRI 05-AUG-2025
DEFINITION  tumor protein p53-inducible protein 11 isoform X1 [Homo sapiens].
ACCESSION   XP_054226527
VERSION     XP_054226527.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370552.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..189
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..189
                     /product="tumor protein p53-inducible protein 11 isoform
                     X1"
                     /calculated_mol_wt=20923
     Region          10..188
                     /region_name="p53-inducible11"
                     /note="Tumour protein p53-inducible protein 11; pfam14936"
                     /db_xref="CDD:464386"
     CDS             1..189
                     /gene="TP53I11"
                     /gene_synonym="PIG11"
                     /coded_by="XM_054370552.1:311..880"
                     /db_xref="GeneID:9537"
                     /db_xref="HGNC:HGNC:16842"
                     /db_xref="MIM:617867"
ORIGIN      
        1 maakqppplm kkhsqtdlvs rlktrkilgv ggedddgevh rskisqvlgn eikftirepl
       61 glrvwqfvsa vlfsgiaima lafpdqlyda vfdgaqvtsk tpirlyggal lsislimwna
      121 lytaekviir wtllteacyf gvqflvvtat laetglmslg illllvsrll fvvisiyyyy
      181 qvgrrpkka
//
LOCUS       XP_054226528             189 aa            linear   PRI 05-AUG-2025
DEFINITION  tumor protein p53-inducible protein 11 isoform X1 [Homo sapiens].
ACCESSION   XP_054226528
VERSION     XP_054226528.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370553.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..189
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..189
                     /product="tumor protein p53-inducible protein 11 isoform
                     X1"
                     /calculated_mol_wt=20923
     Region          10..188
                     /region_name="p53-inducible11"
                     /note="Tumour protein p53-inducible protein 11; pfam14936"
                     /db_xref="CDD:464386"
     CDS             1..189
                     /gene="TP53I11"
                     /gene_synonym="PIG11"
                     /coded_by="XM_054370553.1:132..701"
                     /db_xref="GeneID:9537"
                     /db_xref="HGNC:HGNC:16842"
                     /db_xref="MIM:617867"
ORIGIN      
        1 maakqppplm kkhsqtdlvs rlktrkilgv ggedddgevh rskisqvlgn eikftirepl
       61 glrvwqfvsa vlfsgiaima lafpdqlyda vfdgaqvtsk tpirlyggal lsislimwna
      121 lytaekviir wtllteacyf gvqflvvtat laetglmslg illllvsrll fvvisiyyyy
      181 qvgrrpkka
//
LOCUS       XP_054226529             189 aa            linear   PRI 05-AUG-2025
DEFINITION  tumor protein p53-inducible protein 11 isoform X1 [Homo sapiens].
ACCESSION   XP_054226529
VERSION     XP_054226529.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370554.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..189
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..189
                     /product="tumor protein p53-inducible protein 11 isoform
                     X1"
                     /calculated_mol_wt=20923
     Region          10..188
                     /region_name="p53-inducible11"
                     /note="Tumour protein p53-inducible protein 11; pfam14936"
                     /db_xref="CDD:464386"
     CDS             1..189
                     /gene="TP53I11"
                     /gene_synonym="PIG11"
                     /coded_by="XM_054370554.1:259..828"
                     /db_xref="GeneID:9537"
                     /db_xref="HGNC:HGNC:16842"
                     /db_xref="MIM:617867"
ORIGIN      
        1 maakqppplm kkhsqtdlvs rlktrkilgv ggedddgevh rskisqvlgn eikftirepl
       61 glrvwqfvsa vlfsgiaima lafpdqlyda vfdgaqvtsk tpirlyggal lsislimwna
      121 lytaekviir wtllteacyf gvqflvvtat laetglmslg illllvsrll fvvisiyyyy
      181 qvgrrpkka
//
LOCUS       XP_054226530             154 aa            linear   PRI 05-AUG-2025
DEFINITION  tumor protein p53-inducible protein 11 isoform X2 [Homo sapiens].
ACCESSION   XP_054226530
VERSION     XP_054226530.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370555.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..154
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..154
                     /product="tumor protein p53-inducible protein 11 isoform
                     X2"
                     /calculated_mol_wt=16592
     Region          10..>114
                     /region_name="p53-inducible11"
                     /note="Tumour protein p53-inducible protein 11; pfam14936"
                     /db_xref="CDD:464386"
     CDS             1..154
                     /gene="TP53I11"
                     /gene_synonym="PIG11"
                     /coded_by="XM_054370555.1:234..698"
                     /db_xref="GeneID:9537"
                     /db_xref="HGNC:HGNC:16842"
                     /db_xref="MIM:617867"
ORIGIN      
        1 maakqppplm kkhsqtdlvs rlktrkilgv ggedddgevh rskisqvlgn eikftirepl
       61 glrvwqfvsa vlfsgiaima lafpdqlyda vfdgaqvtsk tpirlyggal lnaaptprpl
      121 mklsagdvlp scghwwntps glelavatic kers
//
LOCUS       XP_054226531             154 aa            linear   PRI 05-AUG-2025
DEFINITION  tumor protein p53-inducible protein 11 isoform X2 [Homo sapiens].
ACCESSION   XP_054226531
VERSION     XP_054226531.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370556.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..154
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..154
                     /product="tumor protein p53-inducible protein 11 isoform
                     X2"
                     /calculated_mol_wt=16592
     Region          10..>114
                     /region_name="p53-inducible11"
                     /note="Tumour protein p53-inducible protein 11; pfam14936"
                     /db_xref="CDD:464386"
     CDS             1..154
                     /gene="TP53I11"
                     /gene_synonym="PIG11"
                     /coded_by="XM_054370556.1:462..926"
                     /db_xref="GeneID:9537"
                     /db_xref="HGNC:HGNC:16842"
                     /db_xref="MIM:617867"
ORIGIN      
        1 maakqppplm kkhsqtdlvs rlktrkilgv ggedddgevh rskisqvlgn eikftirepl
       61 glrvwqfvsa vlfsgiaima lafpdqlyda vfdgaqvtsk tpirlyggal lnaaptprpl
      121 mklsagdvlp scghwwntps glelavatic kers
//
LOCUS       XP_054226535             742 aa            linear   PRI 05-AUG-2025
DEFINITION  CD44 antigen isoform X2 [Homo sapiens].
ACCESSION   XP_054226535
VERSION     XP_054226535.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370560.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..742
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..742
                     /product="CD44 antigen isoform X2"
                     /calculated_mol_wt=81423
     Region          26..170
                     /region_name="Link_domain_CD44_like"
                     /note="This domain is a hyaluronan (HA)-binding domain. It
                     is found in CD44 receptor and mediates adhesive
                     interactions during inflammatory leukocyte homing and
                     tumor metastasis. It also plays an important role in
                     arteriogenesis. The functional HA-binding...; cd03516"
                     /db_xref="CDD:239593"
     Site            order(38,41..42,68,78..79,100..101,105)
                     /site_type="other"
                     /note="putative hyaluronan-binding site [chemical
                     binding]"
                     /db_xref="CDD:239593"
     Region          <381..>639
                     /region_name="ser_rich_anae_1"
                     /note="serine-rich protein; NF033849"
                     /db_xref="CDD:468206"
     CDS             1..742
                     /gene="CD44"
                     /gene_synonym="CDW44; CSPG8; ECM-III; ECMR-III; H-CAM;
                     HCELL; Hermes-1; HUTCH-1; HUTCH-I; LHR; MC56; MDU2; MDU3;
                     MIC4; Pgp1"
                     /coded_by="XM_054370560.1:134..2362"
                     /db_xref="GeneID:960"
                     /db_xref="HGNC:HGNC:1681"
                     /db_xref="MIM:107269"
ORIGIN      
        1 mdkfwwhaaw glclvplsla qidlnitcrf agvfhvekng rysisrteaa dlckafnstl
       61 ptmaqmekal sigfetcryg fieghvvipr ihpnsicaan ntgvyiltsn tsqydtycfn
      121 asappeedct svtdlpnafd gpititivnr dgtryvqkge yrtnpediyp snptdddvss
      181 gssserssts ggyifytfst vhpipdedsp witdstdrip attlmstsat atetatkrqe
      241 twdwfswlfl psesknhlht ttqmagtssn tisagwepne enederdrhl sfsgsgiddd
      301 edfisstist tprafdhtkq nqdwtqwnps hsnpevllqt ttrmtadvdr ngttayegnw
      361 npeahpplih hehheeeetp hststiqatp sstteetatq keqwfgnrwh egyrqtpred
      421 shsttgtaas ahtshpmqgr ttpspedssw tdffnpishp mgrghqagrr mdmdsshstt
      481 lqptanpntg lvedldrtgp lsmttqqsns qsfstshegl eedkdhptts tltssnrndv
      541 tggrrdpnhs egsttllegy tshyphtkes rtfipvtsak tgsfgvtavt vgdsnsnvnr
      601 slsgdqdtfh psggshtthg sesdghshgs qegganttsg pirtpqipew liilasllal
      661 alilavciav nsrrrcgqkk klvinsgnga vedrkpsgln geasksqemv hlvnkesset
      721 pdqfmtadet rnlqnvdmki gv
//
LOCUS       XP_054226539             699 aa            linear   PRI 05-AUG-2025
DEFINITION  CD44 antigen isoform X6 [Homo sapiens].
ACCESSION   XP_054226539
VERSION     XP_054226539.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370564.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..699
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..699
                     /product="CD44 antigen isoform X6"
                     /calculated_mol_wt=76679
     Region          26..170
                     /region_name="Link_domain_CD44_like"
                     /note="This domain is a hyaluronan (HA)-binding domain. It
                     is found in CD44 receptor and mediates adhesive
                     interactions during inflammatory leukocyte homing and
                     tumor metastasis. It also plays an important role in
                     arteriogenesis. The functional HA-binding...; cd03516"
                     /db_xref="CDD:239593"
     Site            order(38,41..42,68,78..79,100..101,105)
                     /site_type="other"
                     /note="putative hyaluronan-binding site [chemical
                     binding]"
                     /db_xref="CDD:239593"
     Region          <381..>596
                     /region_name="ser_rich_anae_1"
                     /note="serine-rich protein; NF033849"
                     /db_xref="CDD:468206"
     CDS             1..699
                     /gene="CD44"
                     /gene_synonym="CDW44; CSPG8; ECM-III; ECMR-III; H-CAM;
                     HCELL; Hermes-1; HUTCH-1; HUTCH-I; LHR; MC56; MDU2; MDU3;
                     MIC4; Pgp1"
                     /coded_by="XM_054370564.1:134..2233"
                     /db_xref="GeneID:960"
                     /db_xref="HGNC:HGNC:1681"
                     /db_xref="MIM:107269"
ORIGIN      
        1 mdkfwwhaaw glclvplsla qidlnitcrf agvfhvekng rysisrteaa dlckafnstl
       61 ptmaqmekal sigfetcryg fieghvvipr ihpnsicaan ntgvyiltsn tsqydtycfn
      121 asappeedct svtdlpnafd gpititivnr dgtryvqkge yrtnpediyp snptdddvss
      181 gssserssts ggyifytfst vhpipdedsp witdstdrip attlmstsat atetatkrqe
      241 twdwfswlfl psesknhlht ttqmagtssn tisagwepne enederdrhl sfsgsgiddd
      301 edfisstist tprafdhtkq nqdwtqwnps hsnpevllqt ttrmtadvdr ngttayegnw
      361 npeahpplih hehheeeetp hststiqatp sstteetatq keqwfgnrwh egyrqtpred
      421 shsttgtadm dsshsttlqp tanpntglve dldrtgplsm ttqqsnsqsf stshegleed
      481 kdhpttstlt ssnrndvtgg rrdpnhsegs ttllegytsh yphtkesrtf ipvtsaktgs
      541 fgvtavtvgd snsnvnrsls gdqdtfhpsg gshtthgses dghshgsqeg ganttsgpir
      601 tpqipewlii lasllalali lavciavnsr rrcgqkkklv insgngaved rkpsglngea
      661 sksqemvhlv nkessetpdq fmtadetrnl qnvdmkigv
//
LOCUS       XP_054226540             675 aa            linear   PRI 05-AUG-2025
DEFINITION  CD44 antigen isoform X7 [Homo sapiens].
ACCESSION   XP_054226540
VERSION     XP_054226540.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370565.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..675
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..675
                     /product="CD44 antigen isoform X7"
                     /calculated_mol_wt=74344
     Region          26..170
                     /region_name="Link_domain_CD44_like"
                     /note="This domain is a hyaluronan (HA)-binding domain. It
                     is found in CD44 receptor and mediates adhesive
                     interactions during inflammatory leukocyte homing and
                     tumor metastasis. It also plays an important role in
                     arteriogenesis. The functional HA-binding...; cd03516"
                     /db_xref="CDD:239593"
     Site            order(38,41..42,68,78..79,100..101,105)
                     /site_type="other"
                     /note="putative hyaluronan-binding site [chemical
                     binding]"
                     /db_xref="CDD:239593"
     Region          362..>572
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     CDS             1..675
                     /gene="CD44"
                     /gene_synonym="CDW44; CSPG8; ECM-III; ECMR-III; H-CAM;
                     HCELL; Hermes-1; HUTCH-1; HUTCH-I; LHR; MC56; MDU2; MDU3;
                     MIC4; Pgp1"
                     /coded_by="XM_054370565.1:134..2161"
                     /db_xref="GeneID:960"
                     /db_xref="HGNC:HGNC:1681"
                     /db_xref="MIM:107269"
ORIGIN      
        1 mdkfwwhaaw glclvplsla qidlnitcrf agvfhvekng rysisrteaa dlckafnstl
       61 ptmaqmekal sigfetcryg fieghvvipr ihpnsicaan ntgvyiltsn tsqydtycfn
      121 asappeedct svtdlpnafd gpititivnr dgtryvqkge yrtnpediyp snptdddvss
      181 gssserssts ggyifytfst vhpipdedsp witdstdrip attlmstsat atetatkrqe
      241 twdwfswlfl psesknhlht ttqmagtssn tisagwepne enederdrhl sfsgsgiddd
      301 edfisstist tprafdhtkq nqdwtqwnps hsnpevllqt ttrmtadvdr ngttayegnw
      361 npeahpplih hehheeeetp hststiqatp sstteetatq keqwfgnrwh egyrqtpred
      421 shsttgtaaa sahtshpmqg rttpspedss wtdffnpish pmgrghqagr rmdmdsshst
      481 tlqptanpnt glvedldrtg plsmttqqsn sqsfstsheg leedkdhptt stltssrdqd
      541 tfhpsggsht thgsesdghs hgsqeggant tsgpirtpqi pewliilasl lalalilavc
      601 iavnsrrrcg qkkklvinsg ngavedrkps glngeasksq emvhlvnkes setpdqfmta
      661 detrnlqnvd mkigv
//
LOCUS       XP_054226544             656 aa            linear   PRI 05-AUG-2025
DEFINITION  CD44 antigen isoform X11 [Homo sapiens].
ACCESSION   XP_054226544
VERSION     XP_054226544.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370569.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..656
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..656
                     /product="CD44 antigen isoform X11"
                     /calculated_mol_wt=71810
     Region          26..170
                     /region_name="Link_domain_CD44_like"
                     /note="This domain is a hyaluronan (HA)-binding domain. It
                     is found in CD44 receptor and mediates adhesive
                     interactions during inflammatory leukocyte homing and
                     tumor metastasis. It also plays an important role in
                     arteriogenesis. The functional HA-binding...; cd03516"
                     /db_xref="CDD:239593"
     Site            order(38,41..42,68,78..79,100..101,105)
                     /site_type="other"
                     /note="putative hyaluronan-binding site [chemical
                     binding]"
                     /db_xref="CDD:239593"
     Region          <295..>553
                     /region_name="ser_rich_anae_1"
                     /note="serine-rich protein; NF033849"
                     /db_xref="CDD:468206"
     CDS             1..656
                     /gene="CD44"
                     /gene_synonym="CDW44; CSPG8; ECM-III; ECMR-III; H-CAM;
                     HCELL; Hermes-1; HUTCH-1; HUTCH-I; LHR; MC56; MDU2; MDU3;
                     MIC4; Pgp1"
                     /coded_by="XM_054370569.1:134..2104"
                     /db_xref="GeneID:960"
                     /db_xref="HGNC:HGNC:1681"
                     /db_xref="MIM:107269"
ORIGIN      
        1 mdkfwwhaaw glclvplsla qidlnitcrf agvfhvekng rysisrteaa dlckafnstl
       61 ptmaqmekal sigfetcryg fieghvvipr ihpnsicaan ntgvyiltsn tsqydtycfn
      121 asappeedct svtdlpnafd gpititivnr dgtryvqkge yrtnpediyp snptdddvss
      181 gssserssts ggyifytfst vhpipdedsp witdstdrip atisttpraf dhtkqnqdwt
      241 qwnpshsnpe vllqtttrmt dvdrngttay egnwnpeahp plihhehhee eetphststi
      301 qatpssttee tatqkeqwfg nrwhegyrqt predshsttg taasahtshp mqgrttpspe
      361 dsswtdffnp ishpmgrghq agrrmdmdss hsttlqptan pntglvedld rtgplsmttq
      421 qsnsqsfsts hegleedkdh pttstltssn rndvtggrrd pnhsegsttl legytshyph
      481 tkesrtfipv tsaktgsfgv tavtvgdsns nvnrslsgdq dtfhpsggsh tthgsesdgh
      541 shgsqeggan ttsgpirtpq ipewliilas llalalilav ciavnsrrrc gqkkklvins
      601 gngavedrkp sglngeasks qemvhlvnke ssetpdqfmt adetrnlqnv dmkigv
//
LOCUS       XP_054226555             446 aa            linear   PRI 05-AUG-2025
DEFINITION  CD44 antigen isoform X22 [Homo sapiens].
ACCESSION   XP_054226555
VERSION     XP_054226555.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370580.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..446
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..446
                     /product="CD44 antigen isoform X22"
                     /calculated_mol_wt=49925
     Region          26..170
                     /region_name="Link_domain_CD44_like"
                     /note="This domain is a hyaluronan (HA)-binding domain. It
                     is found in CD44 receptor and mediates adhesive
                     interactions during inflammatory leukocyte homing and
                     tumor metastasis. It also plays an important role in
                     arteriogenesis. The functional HA-binding...; cd03516"
                     /db_xref="CDD:239593"
     Site            order(38,41..42,68,78..79,100..101,105)
                     /site_type="other"
                     /note="putative hyaluronan-binding site [chemical
                     binding]"
                     /db_xref="CDD:239593"
     CDS             1..446
                     /gene="CD44"
                     /gene_synonym="CDW44; CSPG8; ECM-III; ECMR-III; H-CAM;
                     HCELL; Hermes-1; HUTCH-1; HUTCH-I; LHR; MC56; MDU2; MDU3;
                     MIC4; Pgp1"
                     /coded_by="XM_054370580.1:134..1474"
                     /db_xref="GeneID:960"
                     /db_xref="HGNC:HGNC:1681"
                     /db_xref="MIM:107269"
ORIGIN      
        1 mdkfwwhaaw glclvplsla qidlnitcrf agvfhvekng rysisrteaa dlckafnstl
       61 ptmaqmekal sigfetcryg fieghvvipr ihpnsicaan ntgvyiltsn tsqydtycfn
      121 asappeedct svtdlpnafd gpititivnr dgtryvqkge yrtnpediyp snptdddvss
      181 gssserssts ggyifytfst vhpipdedsp witdstdrip attlmstsat atetatkrqe
      241 twdwfswlfl psesknhlht ttqmagtssn tisagwepne enederdrhl sfsgsgiddd
      301 edfisstist tprafdhtkq nqdwtqwnps hsnpevllqt ttrmtadvdr ngttayegnw
      361 npeahpplih hehheeeetp hststiqatp sstteetatq keqwfgnrwh egyrqtpred
      421 shsttgtagd cgsmawvkky fsfifl
//
LOCUS       XP_054226561            1244 aa            linear   PRI 05-AUG-2025
DEFINITION  membrane-associated phosphatidylinositol transfer protein 1 isoform
            X1 [Homo sapiens].
ACCESSION   XP_054226561
VERSION     XP_054226561.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370586.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1244
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1244
                     /product="membrane-associated phosphatidylinositol
                     transfer protein 1 isoform X1"
                     /calculated_mol_wt=134717
     Region          1..257
                     /region_name="SRPBCC_PITPNM1-2_like"
                     /note="Lipid-binding SRPBCC domain of mammalian PITPNM1-2
                     and related proteins (Class IIA PITPs); cd08889"
                     /db_xref="CDD:176898"
     Site            order(21..22,25,29,32,40,59,61,63,65,68,70,73,77,81..82,
                     84,86,88,90,95,97,99,102..103,109,111,191,197,199,209,
                     217..219,222)
                     /site_type="other"
                     /note="putative lipid binding site [chemical binding]"
                     /db_xref="CDD:176898"
     Site            65..83
                     /site_type="active"
                     /note="putative lipid exchange loop [active]"
                     /db_xref="CDD:176898"
     Site            order(118..147,153..177,185..186)
                     /site_type="active"
                     /note="putatative regulatory loop [active]"
                     /db_xref="CDD:176898"
     Site            164
                     /site_type="other"
                     /note="putative PKC phosphorylation site
                     [posttranslational modification]"
                     /db_xref="CDD:176898"
     Region          606..>707
                     /region_name="SAV_2336_NTERM"
                     /note="SAV_2336 family N-terminal domain; NF041121"
                     /db_xref="CDD:469044"
     Region          686..879
                     /region_name="DDHD"
                     /note="DDHD domain; pfam02862"
                     /db_xref="CDD:460725"
     Region          1023..1154
                     /region_name="LNS2"
                     /note="This domain is found in Saccharomyces cerevisiae
                     protein SMP2, proteins with an N-terminal lipin domain and
                     phosphatidylinositol transfer proteins; smart00775"
                     /db_xref="CDD:197870"
     CDS             1..1244
                     /gene="PITPNM1"
                     /gene_synonym="DRES9; NIR2; PITPNM; Rd9; RDGB; RDGB1;
                     RDGBA; RDGBA1"
                     /coded_by="XM_054370586.1:283..4017"
                     /db_xref="GeneID:9600"
                     /db_xref="HGNC:HGNC:9003"
                     /db_xref="MIM:608794"
ORIGIN      
        1 mlikeyhill pmsldeyqva qlymiqkksr eessgegsgv eilanrpytd gpggsgqyth
       61 kvyhvgship gwfrallpka alqveeeswn aypytrtryt cpfvekfsie ietyylpdgg
      121 qqpnvfnlsg aerrqrildt idivrdavap geykaeedpr lyhsvktgrg plsddwarta
      181 aqtgplmcay klckvefryw gmqakieqfi hdvglrrvml rahrqawcwq dewtelsmad
      241 iraleeetar mlaqrmakcn tgsegseaqp pgkpstears aasntgtpdg peappgpdas
      301 pdasfgkqws sssrssyssq hggavspqsl sewrmqniar dsensseeef fdahegfsds
      361 eevfpkemtk wnsndfidaf aspveaegtp epgaeaakgi edgaqaprds egldgagelg
      421 aeacavhalf lilhsgnild sgpgdanskq advqtlssaf eavtrihfpe alghvalrlv
      481 pcppicaaay alvsnlspys hdgdslsrsq dhiplaalpl latsssryqg avatviartn
      541 qaysaflrsp egagfcgqva ligdgvggil gfdalchsan agtgsrgssr rgsmnnells
      601 pefgpvrdpl adgveglgrg spepsalppq ripsdmaspe pegsqnslqa apattsswep
      661 rrastafcpp aasseapdgp sstarldfkv sgfflfgspl glvlalrktv mpaleaaqmr
      721 paceqiynlf haadpcasrl epllapkfqa iapltvpryq kfplgdgssl lladtlqths
      781 slfleeleml vpstptstsg afwkgselat dppaqpaaps ttsevvkile rwwgtkridy
      841 slycpealta fptvtlphlf hasywesadv vafilrqvie kerpqlaece epsiyspafp
      901 rekwqrkrtq vkirnvtsnh rasdtvvceg rpqvlsgrfm ygpldvvtlt gekvdvyimt
      961 qplsgkwihf gtevtnssgr ltfpvppera lgigvypvrm vvrgdhtyae ccltvvargt
     1021 eavvfsidgs ftasvsimgs dpkvragavd vvrhwqdsgy livyvtgrpd mqkhrvvawl
     1081 sqhnfphgvv sfcdglthdp lrqkamflqs lvqevelniv agygspkdva vyaalglsps
     1141 qtyivgravr klqaqcqfls dgyvahlgql eagshshass gppraalgks sygvaapvdf
     1201 lrkqsqllrs rgpsqaereg pgtppttlar gkarsislkl dsee
//
LOCUS       XP_054226562            1244 aa            linear   PRI 05-AUG-2025
DEFINITION  membrane-associated phosphatidylinositol transfer protein 1 isoform
            X1 [Homo sapiens].
ACCESSION   XP_054226562
VERSION     XP_054226562.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370587.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1244
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1244
                     /product="membrane-associated phosphatidylinositol
                     transfer protein 1 isoform X1"
                     /calculated_mol_wt=134717
     Region          1..257
                     /region_name="SRPBCC_PITPNM1-2_like"
                     /note="Lipid-binding SRPBCC domain of mammalian PITPNM1-2
                     and related proteins (Class IIA PITPs); cd08889"
                     /db_xref="CDD:176898"
     Site            order(21..22,25,29,32,40,59,61,63,65,68,70,73,77,81..82,
                     84,86,88,90,95,97,99,102..103,109,111,191,197,199,209,
                     217..219,222)
                     /site_type="other"
                     /note="putative lipid binding site [chemical binding]"
                     /db_xref="CDD:176898"
     Site            65..83
                     /site_type="active"
                     /note="putative lipid exchange loop [active]"
                     /db_xref="CDD:176898"
     Site            order(118..147,153..177,185..186)
                     /site_type="active"
                     /note="putatative regulatory loop [active]"
                     /db_xref="CDD:176898"
     Site            164
                     /site_type="other"
                     /note="putative PKC phosphorylation site
                     [posttranslational modification]"
                     /db_xref="CDD:176898"
     Region          606..>707
                     /region_name="SAV_2336_NTERM"
                     /note="SAV_2336 family N-terminal domain; NF041121"
                     /db_xref="CDD:469044"
     Region          686..879
                     /region_name="DDHD"
                     /note="DDHD domain; pfam02862"
                     /db_xref="CDD:460725"
     Region          1023..1154
                     /region_name="LNS2"
                     /note="This domain is found in Saccharomyces cerevisiae
                     protein SMP2, proteins with an N-terminal lipin domain and
                     phosphatidylinositol transfer proteins; smart00775"
                     /db_xref="CDD:197870"
     CDS             1..1244
                     /gene="PITPNM1"
                     /gene_synonym="DRES9; NIR2; PITPNM; Rd9; RDGB; RDGB1;
                     RDGBA; RDGBA1"
                     /coded_by="XM_054370587.1:104..3838"
                     /db_xref="GeneID:9600"
                     /db_xref="HGNC:HGNC:9003"
                     /db_xref="MIM:608794"
ORIGIN      
        1 mlikeyhill pmsldeyqva qlymiqkksr eessgegsgv eilanrpytd gpggsgqyth
       61 kvyhvgship gwfrallpka alqveeeswn aypytrtryt cpfvekfsie ietyylpdgg
      121 qqpnvfnlsg aerrqrildt idivrdavap geykaeedpr lyhsvktgrg plsddwarta
      181 aqtgplmcay klckvefryw gmqakieqfi hdvglrrvml rahrqawcwq dewtelsmad
      241 iraleeetar mlaqrmakcn tgsegseaqp pgkpstears aasntgtpdg peappgpdas
      301 pdasfgkqws sssrssyssq hggavspqsl sewrmqniar dsensseeef fdahegfsds
      361 eevfpkemtk wnsndfidaf aspveaegtp epgaeaakgi edgaqaprds egldgagelg
      421 aeacavhalf lilhsgnild sgpgdanskq advqtlssaf eavtrihfpe alghvalrlv
      481 pcppicaaay alvsnlspys hdgdslsrsq dhiplaalpl latsssryqg avatviartn
      541 qaysaflrsp egagfcgqva ligdgvggil gfdalchsan agtgsrgssr rgsmnnells
      601 pefgpvrdpl adgveglgrg spepsalppq ripsdmaspe pegsqnslqa apattsswep
      661 rrastafcpp aasseapdgp sstarldfkv sgfflfgspl glvlalrktv mpaleaaqmr
      721 paceqiynlf haadpcasrl epllapkfqa iapltvpryq kfplgdgssl lladtlqths
      781 slfleeleml vpstptstsg afwkgselat dppaqpaaps ttsevvkile rwwgtkridy
      841 slycpealta fptvtlphlf hasywesadv vafilrqvie kerpqlaece epsiyspafp
      901 rekwqrkrtq vkirnvtsnh rasdtvvceg rpqvlsgrfm ygpldvvtlt gekvdvyimt
      961 qplsgkwihf gtevtnssgr ltfpvppera lgigvypvrm vvrgdhtyae ccltvvargt
     1021 eavvfsidgs ftasvsimgs dpkvragavd vvrhwqdsgy livyvtgrpd mqkhrvvawl
     1081 sqhnfphgvv sfcdglthdp lrqkamflqs lvqevelniv agygspkdva vyaalglsps
     1141 qtyivgravr klqaqcqfls dgyvahlgql eagshshass gppraalgks sygvaapvdf
     1201 lrkqsqllrs rgpsqaereg pgtppttlar gkarsislkl dsee
//
LOCUS       XP_054226563            1244 aa            linear   PRI 05-AUG-2025
DEFINITION  membrane-associated phosphatidylinositol transfer protein 1 isoform
            X1 [Homo sapiens].
ACCESSION   XP_054226563
VERSION     XP_054226563.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370588.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1244
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1244
                     /product="membrane-associated phosphatidylinositol
                     transfer protein 1 isoform X1"
                     /calculated_mol_wt=134717
     Region          1..257
                     /region_name="SRPBCC_PITPNM1-2_like"
                     /note="Lipid-binding SRPBCC domain of mammalian PITPNM1-2
                     and related proteins (Class IIA PITPs); cd08889"
                     /db_xref="CDD:176898"
     Site            order(21..22,25,29,32,40,59,61,63,65,68,70,73,77,81..82,
                     84,86,88,90,95,97,99,102..103,109,111,191,197,199,209,
                     217..219,222)
                     /site_type="other"
                     /note="putative lipid binding site [chemical binding]"
                     /db_xref="CDD:176898"
     Site            65..83
                     /site_type="active"
                     /note="putative lipid exchange loop [active]"
                     /db_xref="CDD:176898"
     Site            order(118..147,153..177,185..186)
                     /site_type="active"
                     /note="putatative regulatory loop [active]"
                     /db_xref="CDD:176898"
     Site            164
                     /site_type="other"
                     /note="putative PKC phosphorylation site
                     [posttranslational modification]"
                     /db_xref="CDD:176898"
     Region          606..>707
                     /region_name="SAV_2336_NTERM"
                     /note="SAV_2336 family N-terminal domain; NF041121"
                     /db_xref="CDD:469044"
     Region          686..879
                     /region_name="DDHD"
                     /note="DDHD domain; pfam02862"
                     /db_xref="CDD:460725"
     Region          1023..1154
                     /region_name="LNS2"
                     /note="This domain is found in Saccharomyces cerevisiae
                     protein SMP2, proteins with an N-terminal lipin domain and
                     phosphatidylinositol transfer proteins; smart00775"
                     /db_xref="CDD:197870"
     CDS             1..1244
                     /gene="PITPNM1"
                     /gene_synonym="DRES9; NIR2; PITPNM; Rd9; RDGB; RDGB1;
                     RDGBA; RDGBA1"
                     /coded_by="XM_054370588.1:133..3867"
                     /db_xref="GeneID:9600"
                     /db_xref="HGNC:HGNC:9003"
                     /db_xref="MIM:608794"
ORIGIN      
        1 mlikeyhill pmsldeyqva qlymiqkksr eessgegsgv eilanrpytd gpggsgqyth
       61 kvyhvgship gwfrallpka alqveeeswn aypytrtryt cpfvekfsie ietyylpdgg
      121 qqpnvfnlsg aerrqrildt idivrdavap geykaeedpr lyhsvktgrg plsddwarta
      181 aqtgplmcay klckvefryw gmqakieqfi hdvglrrvml rahrqawcwq dewtelsmad
      241 iraleeetar mlaqrmakcn tgsegseaqp pgkpstears aasntgtpdg peappgpdas
      301 pdasfgkqws sssrssyssq hggavspqsl sewrmqniar dsensseeef fdahegfsds
      361 eevfpkemtk wnsndfidaf aspveaegtp epgaeaakgi edgaqaprds egldgagelg
      421 aeacavhalf lilhsgnild sgpgdanskq advqtlssaf eavtrihfpe alghvalrlv
      481 pcppicaaay alvsnlspys hdgdslsrsq dhiplaalpl latsssryqg avatviartn
      541 qaysaflrsp egagfcgqva ligdgvggil gfdalchsan agtgsrgssr rgsmnnells
      601 pefgpvrdpl adgveglgrg spepsalppq ripsdmaspe pegsqnslqa apattsswep
      661 rrastafcpp aasseapdgp sstarldfkv sgfflfgspl glvlalrktv mpaleaaqmr
      721 paceqiynlf haadpcasrl epllapkfqa iapltvpryq kfplgdgssl lladtlqths
      781 slfleeleml vpstptstsg afwkgselat dppaqpaaps ttsevvkile rwwgtkridy
      841 slycpealta fptvtlphlf hasywesadv vafilrqvie kerpqlaece epsiyspafp
      901 rekwqrkrtq vkirnvtsnh rasdtvvceg rpqvlsgrfm ygpldvvtlt gekvdvyimt
      961 qplsgkwihf gtevtnssgr ltfpvppera lgigvypvrm vvrgdhtyae ccltvvargt
     1021 eavvfsidgs ftasvsimgs dpkvragavd vvrhwqdsgy livyvtgrpd mqkhrvvawl
     1081 sqhnfphgvv sfcdglthdp lrqkamflqs lvqevelniv agygspkdva vyaalglsps
     1141 qtyivgravr klqaqcqfls dgyvahlgql eagshshass gppraalgks sygvaapvdf
     1201 lrkqsqllrs rgpsqaereg pgtppttlar gkarsislkl dsee
//
LOCUS       XP_054226564            1244 aa            linear   PRI 05-AUG-2025
DEFINITION  membrane-associated phosphatidylinositol transfer protein 1 isoform
            X1 [Homo sapiens].
ACCESSION   XP_054226564
VERSION     XP_054226564.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370589.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1244
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1244
                     /product="membrane-associated phosphatidylinositol
                     transfer protein 1 isoform X1"
                     /calculated_mol_wt=134717
     Region          1..257
                     /region_name="SRPBCC_PITPNM1-2_like"
                     /note="Lipid-binding SRPBCC domain of mammalian PITPNM1-2
                     and related proteins (Class IIA PITPs); cd08889"
                     /db_xref="CDD:176898"
     Site            order(21..22,25,29,32,40,59,61,63,65,68,70,73,77,81..82,
                     84,86,88,90,95,97,99,102..103,109,111,191,197,199,209,
                     217..219,222)
                     /site_type="other"
                     /note="putative lipid binding site [chemical binding]"
                     /db_xref="CDD:176898"
     Site            65..83
                     /site_type="active"
                     /note="putative lipid exchange loop [active]"
                     /db_xref="CDD:176898"
     Site            order(118..147,153..177,185..186)
                     /site_type="active"
                     /note="putatative regulatory loop [active]"
                     /db_xref="CDD:176898"
     Site            164
                     /site_type="other"
                     /note="putative PKC phosphorylation site
                     [posttranslational modification]"
                     /db_xref="CDD:176898"
     Region          606..>707
                     /region_name="SAV_2336_NTERM"
                     /note="SAV_2336 family N-terminal domain; NF041121"
                     /db_xref="CDD:469044"
     Region          686..879
                     /region_name="DDHD"
                     /note="DDHD domain; pfam02862"
                     /db_xref="CDD:460725"
     Region          1023..1154
                     /region_name="LNS2"
                     /note="This domain is found in Saccharomyces cerevisiae
                     protein SMP2, proteins with an N-terminal lipin domain and
                     phosphatidylinositol transfer proteins; smart00775"
                     /db_xref="CDD:197870"
     CDS             1..1244
                     /gene="PITPNM1"
                     /gene_synonym="DRES9; NIR2; PITPNM; Rd9; RDGB; RDGB1;
                     RDGBA; RDGBA1"
                     /coded_by="XM_054370589.1:326..4060"
                     /db_xref="GeneID:9600"
                     /db_xref="HGNC:HGNC:9003"
                     /db_xref="MIM:608794"
ORIGIN      
        1 mlikeyhill pmsldeyqva qlymiqkksr eessgegsgv eilanrpytd gpggsgqyth
       61 kvyhvgship gwfrallpka alqveeeswn aypytrtryt cpfvekfsie ietyylpdgg
      121 qqpnvfnlsg aerrqrildt idivrdavap geykaeedpr lyhsvktgrg plsddwarta
      181 aqtgplmcay klckvefryw gmqakieqfi hdvglrrvml rahrqawcwq dewtelsmad
      241 iraleeetar mlaqrmakcn tgsegseaqp pgkpstears aasntgtpdg peappgpdas
      301 pdasfgkqws sssrssyssq hggavspqsl sewrmqniar dsensseeef fdahegfsds
      361 eevfpkemtk wnsndfidaf aspveaegtp epgaeaakgi edgaqaprds egldgagelg
      421 aeacavhalf lilhsgnild sgpgdanskq advqtlssaf eavtrihfpe alghvalrlv
      481 pcppicaaay alvsnlspys hdgdslsrsq dhiplaalpl latsssryqg avatviartn
      541 qaysaflrsp egagfcgqva ligdgvggil gfdalchsan agtgsrgssr rgsmnnells
      601 pefgpvrdpl adgveglgrg spepsalppq ripsdmaspe pegsqnslqa apattsswep
      661 rrastafcpp aasseapdgp sstarldfkv sgfflfgspl glvlalrktv mpaleaaqmr
      721 paceqiynlf haadpcasrl epllapkfqa iapltvpryq kfplgdgssl lladtlqths
      781 slfleeleml vpstptstsg afwkgselat dppaqpaaps ttsevvkile rwwgtkridy
      841 slycpealta fptvtlphlf hasywesadv vafilrqvie kerpqlaece epsiyspafp
      901 rekwqrkrtq vkirnvtsnh rasdtvvceg rpqvlsgrfm ygpldvvtlt gekvdvyimt
      961 qplsgkwihf gtevtnssgr ltfpvppera lgigvypvrm vvrgdhtyae ccltvvargt
     1021 eavvfsidgs ftasvsimgs dpkvragavd vvrhwqdsgy livyvtgrpd mqkhrvvawl
     1081 sqhnfphgvv sfcdglthdp lrqkamflqs lvqevelniv agygspkdva vyaalglsps
     1141 qtyivgravr klqaqcqfls dgyvahlgql eagshshass gppraalgks sygvaapvdf
     1201 lrkqsqllrs rgpsqaereg pgtppttlar gkarsislkl dsee
//
LOCUS       XP_054226565            1243 aa            linear   PRI 05-AUG-2025
DEFINITION  membrane-associated phosphatidylinositol transfer protein 1 isoform
            X2 [Homo sapiens].
ACCESSION   XP_054226565
VERSION     XP_054226565.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370590.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1243
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1243
                     /product="membrane-associated phosphatidylinositol
                     transfer protein 1 isoform X2"
                     /calculated_mol_wt=134646
     Region          1..257
                     /region_name="SRPBCC_PITPNM1-2_like"
                     /note="Lipid-binding SRPBCC domain of mammalian PITPNM1-2
                     and related proteins (Class IIA PITPs); cd08889"
                     /db_xref="CDD:176898"
     Site            order(21..22,25,29,32,40,59,61,63,65,68,70,73,77,81..82,
                     84,86,88,90,95,97,99,102..103,109,111,191,197,199,209,
                     217..219,222)
                     /site_type="other"
                     /note="putative lipid binding site [chemical binding]"
                     /db_xref="CDD:176898"
     Site            65..83
                     /site_type="active"
                     /note="putative lipid exchange loop [active]"
                     /db_xref="CDD:176898"
     Site            order(118..147,153..177,185..186)
                     /site_type="active"
                     /note="putatative regulatory loop [active]"
                     /db_xref="CDD:176898"
     Site            164
                     /site_type="other"
                     /note="putative PKC phosphorylation site
                     [posttranslational modification]"
                     /db_xref="CDD:176898"
     Region          606..>707
                     /region_name="SAV_2336_NTERM"
                     /note="SAV_2336 family N-terminal domain; NF041121"
                     /db_xref="CDD:469044"
     Region          686..878
                     /region_name="DDHD"
                     /note="DDHD domain; pfam02862"
                     /db_xref="CDD:460725"
     Region          1022..1153
                     /region_name="LNS2"
                     /note="This domain is found in Saccharomyces cerevisiae
                     protein SMP2, proteins with an N-terminal lipin domain and
                     phosphatidylinositol transfer proteins; smart00775"
                     /db_xref="CDD:197870"
     CDS             1..1243
                     /gene="PITPNM1"
                     /gene_synonym="DRES9; NIR2; PITPNM; Rd9; RDGB; RDGB1;
                     RDGBA; RDGBA1"
                     /coded_by="XM_054370590.1:424..4155"
                     /db_xref="GeneID:9600"
                     /db_xref="HGNC:HGNC:9003"
                     /db_xref="MIM:608794"
ORIGIN      
        1 mlikeyhill pmsldeyqva qlymiqkksr eessgegsgv eilanrpytd gpggsgqyth
       61 kvyhvgship gwfrallpka alqveeeswn aypytrtryt cpfvekfsie ietyylpdgg
      121 qqpnvfnlsg aerrqrildt idivrdavap geykaeedpr lyhsvktgrg plsddwarta
      181 aqtgplmcay klckvefryw gmqakieqfi hdvglrrvml rahrqawcwq dewtelsmad
      241 iraleeetar mlaqrmakcn tgsegseaqp pgkpstears aasntgtpdg peappgpdas
      301 pdasfgkqws sssrssyssq hggavspqsl sewrmqniar dsensseeef fdahegfsds
      361 eevfpkemtk wnsndfidaf aspveaegtp epgaeaakgi edgaqaprds egldgagelg
      421 aeacavhalf lilhsgnild sgpgdanskq advqtlssaf eavtrihfpe alghvalrlv
      481 pcppicaaay alvsnlspys hdgdslsrsq dhiplaalpl latsssryqg avatviartn
      541 qaysaflrsp egagfcgqva ligdgvggil gfdalchsan agtgsrgssr rgsmnnells
      601 pefgpvrdpl adgveglgrg spepsalppq ripsdmaspe pegsqnslqa apattsswep
      661 rrastafcpp aasseapdgp sstarldfkv sgfflfgspl glvlalrktv mpaleaqmrp
      721 aceqiynlfh aadpcasrle pllapkfqai apltvpryqk fplgdgssll ladtlqthss
      781 lfleelemlv pstptstsga fwkgselatd ppaqpaapst tsevvkiler wwgtkridys
      841 lycpealtaf ptvtlphlfh asywesadvv afilrqviek erpqlaecee psiyspafpr
      901 ekwqrkrtqv kirnvtsnhr asdtvvcegr pqvlsgrfmy gpldvvtltg ekvdvyimtq
      961 plsgkwihfg tevtnssgrl tfpvpperal gigvypvrmv vrgdhtyaec cltvvargte
     1021 avvfsidgsf tasvsimgsd pkvragavdv vrhwqdsgyl ivyvtgrpdm qkhrvvawls
     1081 qhnfphgvvs fcdglthdpl rqkamflqsl vqevelniva gygspkdvav yaalglspsq
     1141 tyivgravrk lqaqcqflsd gyvahlgqle agshshassg ppraalgkss ygvaapvdfl
     1201 rkqsqllrsr gpsqaeregp gtppttlarg karsislkld see
//
LOCUS       XP_054226566            1243 aa            linear   PRI 05-AUG-2025
DEFINITION  membrane-associated phosphatidylinositol transfer protein 1 isoform
            X2 [Homo sapiens].
ACCESSION   XP_054226566
VERSION     XP_054226566.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370591.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1243
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1243
                     /product="membrane-associated phosphatidylinositol
                     transfer protein 1 isoform X2"
                     /calculated_mol_wt=134646
     Region          1..257
                     /region_name="SRPBCC_PITPNM1-2_like"
                     /note="Lipid-binding SRPBCC domain of mammalian PITPNM1-2
                     and related proteins (Class IIA PITPs); cd08889"
                     /db_xref="CDD:176898"
     Site            order(21..22,25,29,32,40,59,61,63,65,68,70,73,77,81..82,
                     84,86,88,90,95,97,99,102..103,109,111,191,197,199,209,
                     217..219,222)
                     /site_type="other"
                     /note="putative lipid binding site [chemical binding]"
                     /db_xref="CDD:176898"
     Site            65..83
                     /site_type="active"
                     /note="putative lipid exchange loop [active]"
                     /db_xref="CDD:176898"
     Site            order(118..147,153..177,185..186)
                     /site_type="active"
                     /note="putatative regulatory loop [active]"
                     /db_xref="CDD:176898"
     Site            164
                     /site_type="other"
                     /note="putative PKC phosphorylation site
                     [posttranslational modification]"
                     /db_xref="CDD:176898"
     Region          606..>707
                     /region_name="SAV_2336_NTERM"
                     /note="SAV_2336 family N-terminal domain; NF041121"
                     /db_xref="CDD:469044"
     Region          686..878
                     /region_name="DDHD"
                     /note="DDHD domain; pfam02862"
                     /db_xref="CDD:460725"
     Region          1022..1153
                     /region_name="LNS2"
                     /note="This domain is found in Saccharomyces cerevisiae
                     protein SMP2, proteins with an N-terminal lipin domain and
                     phosphatidylinositol transfer proteins; smart00775"
                     /db_xref="CDD:197870"
     CDS             1..1243
                     /gene="PITPNM1"
                     /gene_synonym="DRES9; NIR2; PITPNM; Rd9; RDGB; RDGB1;
                     RDGBA; RDGBA1"
                     /coded_by="XM_054370591.1:227..3958"
                     /db_xref="GeneID:9600"
                     /db_xref="HGNC:HGNC:9003"
                     /db_xref="MIM:608794"
ORIGIN      
        1 mlikeyhill pmsldeyqva qlymiqkksr eessgegsgv eilanrpytd gpggsgqyth
       61 kvyhvgship gwfrallpka alqveeeswn aypytrtryt cpfvekfsie ietyylpdgg
      121 qqpnvfnlsg aerrqrildt idivrdavap geykaeedpr lyhsvktgrg plsddwarta
      181 aqtgplmcay klckvefryw gmqakieqfi hdvglrrvml rahrqawcwq dewtelsmad
      241 iraleeetar mlaqrmakcn tgsegseaqp pgkpstears aasntgtpdg peappgpdas
      301 pdasfgkqws sssrssyssq hggavspqsl sewrmqniar dsensseeef fdahegfsds
      361 eevfpkemtk wnsndfidaf aspveaegtp epgaeaakgi edgaqaprds egldgagelg
      421 aeacavhalf lilhsgnild sgpgdanskq advqtlssaf eavtrihfpe alghvalrlv
      481 pcppicaaay alvsnlspys hdgdslsrsq dhiplaalpl latsssryqg avatviartn
      541 qaysaflrsp egagfcgqva ligdgvggil gfdalchsan agtgsrgssr rgsmnnells
      601 pefgpvrdpl adgveglgrg spepsalppq ripsdmaspe pegsqnslqa apattsswep
      661 rrastafcpp aasseapdgp sstarldfkv sgfflfgspl glvlalrktv mpaleaqmrp
      721 aceqiynlfh aadpcasrle pllapkfqai apltvpryqk fplgdgssll ladtlqthss
      781 lfleelemlv pstptstsga fwkgselatd ppaqpaapst tsevvkiler wwgtkridys
      841 lycpealtaf ptvtlphlfh asywesadvv afilrqviek erpqlaecee psiyspafpr
      901 ekwqrkrtqv kirnvtsnhr asdtvvcegr pqvlsgrfmy gpldvvtltg ekvdvyimtq
      961 plsgkwihfg tevtnssgrl tfpvpperal gigvypvrmv vrgdhtyaec cltvvargte
     1021 avvfsidgsf tasvsimgsd pkvragavdv vrhwqdsgyl ivyvtgrpdm qkhrvvawls
     1081 qhnfphgvvs fcdglthdpl rqkamflqsl vqevelniva gygspkdvav yaalglspsq
     1141 tyivgravrk lqaqcqflsd gyvahlgqle agshshassg ppraalgkss ygvaapvdfl
     1201 rkqsqllrsr gpsqaeregp gtppttlarg karsislkld see
//
LOCUS       XP_054226567            1243 aa            linear   PRI 05-AUG-2025
DEFINITION  membrane-associated phosphatidylinositol transfer protein 1 isoform
            X2 [Homo sapiens].
ACCESSION   XP_054226567
VERSION     XP_054226567.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370592.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1243
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1243
                     /product="membrane-associated phosphatidylinositol
                     transfer protein 1 isoform X2"
                     /calculated_mol_wt=134646
     Region          1..257
                     /region_name="SRPBCC_PITPNM1-2_like"
                     /note="Lipid-binding SRPBCC domain of mammalian PITPNM1-2
                     and related proteins (Class IIA PITPs); cd08889"
                     /db_xref="CDD:176898"
     Site            order(21..22,25,29,32,40,59,61,63,65,68,70,73,77,81..82,
                     84,86,88,90,95,97,99,102..103,109,111,191,197,199,209,
                     217..219,222)
                     /site_type="other"
                     /note="putative lipid binding site [chemical binding]"
                     /db_xref="CDD:176898"
     Site            65..83
                     /site_type="active"
                     /note="putative lipid exchange loop [active]"
                     /db_xref="CDD:176898"
     Site            order(118..147,153..177,185..186)
                     /site_type="active"
                     /note="putatative regulatory loop [active]"
                     /db_xref="CDD:176898"
     Site            164
                     /site_type="other"
                     /note="putative PKC phosphorylation site
                     [posttranslational modification]"
                     /db_xref="CDD:176898"
     Region          606..>707
                     /region_name="SAV_2336_NTERM"
                     /note="SAV_2336 family N-terminal domain; NF041121"
                     /db_xref="CDD:469044"
     Region          686..878
                     /region_name="DDHD"
                     /note="DDHD domain; pfam02862"
                     /db_xref="CDD:460725"
     Region          1022..1153
                     /region_name="LNS2"
                     /note="This domain is found in Saccharomyces cerevisiae
                     protein SMP2, proteins with an N-terminal lipin domain and
                     phosphatidylinositol transfer proteins; smart00775"
                     /db_xref="CDD:197870"
     CDS             1..1243
                     /gene="PITPNM1"
                     /gene_synonym="DRES9; NIR2; PITPNM; Rd9; RDGB; RDGB1;
                     RDGBA; RDGBA1"
                     /coded_by="XM_054370592.1:117..3848"
                     /db_xref="GeneID:9600"
                     /db_xref="HGNC:HGNC:9003"
                     /db_xref="MIM:608794"
ORIGIN      
        1 mlikeyhill pmsldeyqva qlymiqkksr eessgegsgv eilanrpytd gpggsgqyth
       61 kvyhvgship gwfrallpka alqveeeswn aypytrtryt cpfvekfsie ietyylpdgg
      121 qqpnvfnlsg aerrqrildt idivrdavap geykaeedpr lyhsvktgrg plsddwarta
      181 aqtgplmcay klckvefryw gmqakieqfi hdvglrrvml rahrqawcwq dewtelsmad
      241 iraleeetar mlaqrmakcn tgsegseaqp pgkpstears aasntgtpdg peappgpdas
      301 pdasfgkqws sssrssyssq hggavspqsl sewrmqniar dsensseeef fdahegfsds
      361 eevfpkemtk wnsndfidaf aspveaegtp epgaeaakgi edgaqaprds egldgagelg
      421 aeacavhalf lilhsgnild sgpgdanskq advqtlssaf eavtrihfpe alghvalrlv
      481 pcppicaaay alvsnlspys hdgdslsrsq dhiplaalpl latsssryqg avatviartn
      541 qaysaflrsp egagfcgqva ligdgvggil gfdalchsan agtgsrgssr rgsmnnells
      601 pefgpvrdpl adgveglgrg spepsalppq ripsdmaspe pegsqnslqa apattsswep
      661 rrastafcpp aasseapdgp sstarldfkv sgfflfgspl glvlalrktv mpaleaqmrp
      721 aceqiynlfh aadpcasrle pllapkfqai apltvpryqk fplgdgssll ladtlqthss
      781 lfleelemlv pstptstsga fwkgselatd ppaqpaapst tsevvkiler wwgtkridys
      841 lycpealtaf ptvtlphlfh asywesadvv afilrqviek erpqlaecee psiyspafpr
      901 ekwqrkrtqv kirnvtsnhr asdtvvcegr pqvlsgrfmy gpldvvtltg ekvdvyimtq
      961 plsgkwihfg tevtnssgrl tfpvpperal gigvypvrmv vrgdhtyaec cltvvargte
     1021 avvfsidgsf tasvsimgsd pkvragavdv vrhwqdsgyl ivyvtgrpdm qkhrvvawls
     1081 qhnfphgvvs fcdglthdpl rqkamflqsl vqevelniva gygspkdvav yaalglspsq
     1141 tyivgravrk lqaqcqflsd gyvahlgqle agshshassg ppraalgkss ygvaapvdfl
     1201 rkqsqllrsr gpsqaeregp gtppttlarg karsislkld see
//
LOCUS       XP_054226568            1243 aa            linear   PRI 05-AUG-2025
DEFINITION  membrane-associated phosphatidylinositol transfer protein 1 isoform
            X3 [Homo sapiens].
ACCESSION   XP_054226568
VERSION     XP_054226568.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370593.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1243
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1243
                     /product="membrane-associated phosphatidylinositol
                     transfer protein 1 isoform X3"
                     /calculated_mol_wt=134588
     Region          1..257
                     /region_name="SRPBCC_PITPNM1-2_like"
                     /note="Lipid-binding SRPBCC domain of mammalian PITPNM1-2
                     and related proteins (Class IIA PITPs); cd08889"
                     /db_xref="CDD:176898"
     Site            order(21..22,25,29,32,40,59,61,63,65,68,70,73,77,81..82,
                     84,86,88,90,95,97,99,102..103,109,111,191,197,199,209,
                     217..219,222)
                     /site_type="other"
                     /note="putative lipid binding site [chemical binding]"
                     /db_xref="CDD:176898"
     Site            65..83
                     /site_type="active"
                     /note="putative lipid exchange loop [active]"
                     /db_xref="CDD:176898"
     Site            order(118..147,153..177,185..186)
                     /site_type="active"
                     /note="putatative regulatory loop [active]"
                     /db_xref="CDD:176898"
     Site            164
                     /site_type="other"
                     /note="putative PKC phosphorylation site
                     [posttranslational modification]"
                     /db_xref="CDD:176898"
     Region          605..>706
                     /region_name="SAV_2336_NTERM"
                     /note="SAV_2336 family N-terminal domain; NF041121"
                     /db_xref="CDD:469044"
     Region          685..878
                     /region_name="DDHD"
                     /note="DDHD domain; pfam02862"
                     /db_xref="CDD:460725"
     Region          1022..1153
                     /region_name="LNS2"
                     /note="This domain is found in Saccharomyces cerevisiae
                     protein SMP2, proteins with an N-terminal lipin domain and
                     phosphatidylinositol transfer proteins; smart00775"
                     /db_xref="CDD:197870"
     CDS             1..1243
                     /gene="PITPNM1"
                     /gene_synonym="DRES9; NIR2; PITPNM; Rd9; RDGB; RDGB1;
                     RDGBA; RDGBA1"
                     /coded_by="XM_054370593.1:218..3949"
                     /db_xref="GeneID:9600"
                     /db_xref="HGNC:HGNC:9003"
                     /db_xref="MIM:608794"
ORIGIN      
        1 mlikeyhill pmsldeyqva qlymiqkksr eessgegsgv eilanrpytd gpggsgqyth
       61 kvyhvgship gwfrallpka alqveeeswn aypytrtryt cpfvekfsie ietyylpdgg
      121 qqpnvfnlsg aerrqrildt idivrdavap geykaeedpr lyhsvktgrg plsddwarta
      181 aqtgplmcay klckvefryw gmqakieqfi hdvglrrvml rahrqawcwq dewtelsmad
      241 iraleeetar mlaqrmakcn tgsegseaqp pgkpstears aasntgtpdg peappgpdas
      301 pdasfgkqws sssrssyssq hggavspqsl sewrmqniar dsensseeef fdahgfsdse
      361 evfpkemtkw nsndfidafa spveaegtpe pgaeaakgie dgaqaprdse gldgagelga
      421 eacavhalfl ilhsgnilds gpgdanskqa dvqtlssafe avtrihfpea lghvalrlvp
      481 cppicaaaya lvsnlspysh dgdslsrsqd hiplaalpll atsssryqga vatviartnq
      541 aysaflrspe gagfcgqval igdgvggilg fdalchsana gtgsrgssrr gsmnnellsp
      601 efgpvrdpla dgveglgrgs pepsalppqr ipsdmaspep egsqnslqaa pattsswepr
      661 rastafcppa asseapdgps starldfkvs gfflfgsplg lvlalrktvm paleaaqmrp
      721 aceqiynlfh aadpcasrle pllapkfqai apltvpryqk fplgdgssll ladtlqthss
      781 lfleelemlv pstptstsga fwkgselatd ppaqpaapst tsevvkiler wwgtkridys
      841 lycpealtaf ptvtlphlfh asywesadvv afilrqviek erpqlaecee psiyspafpr
      901 ekwqrkrtqv kirnvtsnhr asdtvvcegr pqvlsgrfmy gpldvvtltg ekvdvyimtq
      961 plsgkwihfg tevtnssgrl tfpvpperal gigvypvrmv vrgdhtyaec cltvvargte
     1021 avvfsidgsf tasvsimgsd pkvragavdv vrhwqdsgyl ivyvtgrpdm qkhrvvawls
     1081 qhnfphgvvs fcdglthdpl rqkamflqsl vqevelniva gygspkdvav yaalglspsq
     1141 tyivgravrk lqaqcqflsd gyvahlgqle agshshassg ppraalgkss ygvaapvdfl
     1201 rkqsqllrsr gpsqaeregp gtppttlarg karsislkld see
//
LOCUS       XP_054226569            1242 aa            linear   PRI 05-AUG-2025
DEFINITION  membrane-associated phosphatidylinositol transfer protein 1 isoform
            X4 [Homo sapiens].
ACCESSION   XP_054226569
VERSION     XP_054226569.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370594.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1242
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1242
                     /product="membrane-associated phosphatidylinositol
                     transfer protein 1 isoform X4"
                     /calculated_mol_wt=134517
     Region          1..257
                     /region_name="SRPBCC_PITPNM1-2_like"
                     /note="Lipid-binding SRPBCC domain of mammalian PITPNM1-2
                     and related proteins (Class IIA PITPs); cd08889"
                     /db_xref="CDD:176898"
     Site            order(21..22,25,29,32,40,59,61,63,65,68,70,73,77,81..82,
                     84,86,88,90,95,97,99,102..103,109,111,191,197,199,209,
                     217..219,222)
                     /site_type="other"
                     /note="putative lipid binding site [chemical binding]"
                     /db_xref="CDD:176898"
     Site            65..83
                     /site_type="active"
                     /note="putative lipid exchange loop [active]"
                     /db_xref="CDD:176898"
     Site            order(118..147,153..177,185..186)
                     /site_type="active"
                     /note="putatative regulatory loop [active]"
                     /db_xref="CDD:176898"
     Site            164
                     /site_type="other"
                     /note="putative PKC phosphorylation site
                     [posttranslational modification]"
                     /db_xref="CDD:176898"
     Region          605..>706
                     /region_name="SAV_2336_NTERM"
                     /note="SAV_2336 family N-terminal domain; NF041121"
                     /db_xref="CDD:469044"
     Region          685..877
                     /region_name="DDHD"
                     /note="DDHD domain; pfam02862"
                     /db_xref="CDD:460725"
     Region          1021..1152
                     /region_name="LNS2"
                     /note="This domain is found in Saccharomyces cerevisiae
                     protein SMP2, proteins with an N-terminal lipin domain and
                     phosphatidylinositol transfer proteins; smart00775"
                     /db_xref="CDD:197870"
     CDS             1..1242
                     /gene="PITPNM1"
                     /gene_synonym="DRES9; NIR2; PITPNM; Rd9; RDGB; RDGB1;
                     RDGBA; RDGBA1"
                     /coded_by="XM_054370594.1:131..3859"
                     /db_xref="GeneID:9600"
                     /db_xref="HGNC:HGNC:9003"
                     /db_xref="MIM:608794"
ORIGIN      
        1 mlikeyhill pmsldeyqva qlymiqkksr eessgegsgv eilanrpytd gpggsgqyth
       61 kvyhvgship gwfrallpka alqveeeswn aypytrtryt cpfvekfsie ietyylpdgg
      121 qqpnvfnlsg aerrqrildt idivrdavap geykaeedpr lyhsvktgrg plsddwarta
      181 aqtgplmcay klckvefryw gmqakieqfi hdvglrrvml rahrqawcwq dewtelsmad
      241 iraleeetar mlaqrmakcn tgsegseaqp pgkpstears aasntgtpdg peappgpdas
      301 pdasfgkqws sssrssyssq hggavspqsl sewrmqniar dsensseeef fdahgfsdse
      361 evfpkemtkw nsndfidafa spveaegtpe pgaeaakgie dgaqaprdse gldgagelga
      421 eacavhalfl ilhsgnilds gpgdanskqa dvqtlssafe avtrihfpea lghvalrlvp
      481 cppicaaaya lvsnlspysh dgdslsrsqd hiplaalpll atsssryqga vatviartnq
      541 aysaflrspe gagfcgqval igdgvggilg fdalchsana gtgsrgssrr gsmnnellsp
      601 efgpvrdpla dgveglgrgs pepsalppqr ipsdmaspep egsqnslqaa pattsswepr
      661 rastafcppa asseapdgps starldfkvs gfflfgsplg lvlalrktvm paleaqmrpa
      721 ceqiynlfha adpcasrlep llapkfqaia pltvpryqkf plgdgsslll adtlqthssl
      781 fleelemlvp stptstsgaf wkgselatdp paqpaapstt sevvkilerw wgtkridysl
      841 ycpealtafp tvtlphlfha sywesadvva filrqvieke rpqlaeceep siyspafpre
      901 kwqrkrtqvk irnvtsnhra sdtvvcegrp qvlsgrfmyg pldvvtltge kvdvyimtqp
      961 lsgkwihfgt evtnssgrlt fpvpperalg igvypvrmvv rgdhtyaecc ltvvargtea
     1021 vvfsidgsft asvsimgsdp kvragavdvv rhwqdsgyli vyvtgrpdmq khrvvawlsq
     1081 hnfphgvvsf cdglthdplr qkamflqslv qevelnivag ygspkdvavy aalglspsqt
     1141 yivgravrkl qaqcqflsdg yvahlgqlea gshshassgp praalgkssy gvaapvdflr
     1201 kqsqllrsrg psqaeregpg tppttlargk arsislklds ee
//
LOCUS       XP_054226570            1058 aa            linear   PRI 05-AUG-2025
DEFINITION  membrane-associated phosphatidylinositol transfer protein 1 isoform
            X5 [Homo sapiens].
ACCESSION   XP_054226570
VERSION     XP_054226570.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370595.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1058
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1058
                     /product="membrane-associated phosphatidylinositol
                     transfer protein 1 isoform X5"
                     /calculated_mol_wt=113679
     Region          <1..71
                     /region_name="SRPBCC"
                     /note="START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC)
                     ligand-binding domain superfamily; cl14643"
                     /db_xref="CDD:472699"
     Region          420..>521
                     /region_name="SAV_2336_NTERM"
                     /note="SAV_2336 family N-terminal domain; NF041121"
                     /db_xref="CDD:469044"
     Region          500..693
                     /region_name="DDHD"
                     /note="DDHD domain; pfam02862"
                     /db_xref="CDD:460725"
     Region          837..968
                     /region_name="LNS2"
                     /note="This domain is found in Saccharomyces cerevisiae
                     protein SMP2, proteins with an N-terminal lipin domain and
                     phosphatidylinositol transfer proteins; smart00775"
                     /db_xref="CDD:197870"
     CDS             1..1058
                     /gene="PITPNM1"
                     /gene_synonym="DRES9; NIR2; PITPNM; Rd9; RDGB; RDGB1;
                     RDGBA; RDGBA1"
                     /coded_by="XM_054370595.1:714..3890"
                     /db_xref="GeneID:9600"
                     /db_xref="HGNC:HGNC:9003"
                     /db_xref="MIM:608794"
ORIGIN      
        1 mcayklckve frywgmqaki eqfihdvglr rvmlrahrqa wcwqdewtel smadiralee
       61 etarmlaqrm akcntgsegs eaqppgkpst earsaasntg tpdgpeappg pdaspdasfg
      121 kqwssssrss yssqhggavs pqslsewrmq niardsenss eeeffdaheg fsdseevfpk
      181 emtkwnsndf idafaspvea egtpepgaea akgiedgaqa prdsegldga gelgaeacav
      241 halflilhsg nildsgpgda nskqadvqtl ssafeavtri hfpealghva lrlvpcppic
      301 aaayalvsnl spyshdgdsl srsqdhipla alpllatsss ryqgavatvi artnqaysaf
      361 lrspegagfc gqvaligdgv ggilgfdalc hsanagtgsr gssrrgsmnn ellspefgpv
      421 rdpladgveg lgrgspepsa lppqripsdm aspepegsqn slqaapatts sweprrasta
      481 fcppaassea pdgpsstarl dfkvsgfflf gsplglvlal rktvmpalea aqmrpaceqi
      541 ynlfhaadpc asrlepllap kfqaiapltv pryqkfplgd gssllladtl qthsslflee
      601 lemlvpstpt stsgafwkgs elatdppaqp aapsttsevv kilerwwgtk ridyslycpe
      661 altafptvtl phlfhasywe sadvvafilr qviekerpql aeceepsiys pafprekwqr
      721 krtqvkirnv tsnhrasdtv vcegrpqvls grfmygpldv vtltgekvdv yimtqplsgk
      781 wihfgtevtn ssgrltfpvp peralgigvy pvrmvvrgdh tyaeccltvv argteavvfs
      841 idgsftasvs imgsdpkvra gavdvvrhwq dsgylivyvt grpdmqkhrv vawlsqhnfp
      901 hgvvsfcdgl thdplrqkam flqslvqeve lnivagygsp kdvavyaalg lspsqtyivg
      961 ravrklqaqc qflsdgyvah lgqleagshs hassgppraa lgkssygvaa pvdflrkqsq
     1021 llrsrgpsqa eregpgtppt tlargkarsi slkldsee
//
LOCUS       XP_054226571            1057 aa            linear   PRI 05-AUG-2025
DEFINITION  membrane-associated phosphatidylinositol transfer protein 1 isoform
            X6 [Homo sapiens].
ACCESSION   XP_054226571
VERSION     XP_054226571.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370596.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1057
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1057
                     /product="membrane-associated phosphatidylinositol
                     transfer protein 1 isoform X6"
                     /calculated_mol_wt=113550
     Region          <1..71
                     /region_name="SRPBCC"
                     /note="START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC)
                     ligand-binding domain superfamily; cl14643"
                     /db_xref="CDD:472699"
     Region          419..>520
                     /region_name="SAV_2336_NTERM"
                     /note="SAV_2336 family N-terminal domain; NF041121"
                     /db_xref="CDD:469044"
     Region          499..692
                     /region_name="DDHD"
                     /note="DDHD domain; pfam02862"
                     /db_xref="CDD:460725"
     Region          836..967
                     /region_name="LNS2"
                     /note="This domain is found in Saccharomyces cerevisiae
                     protein SMP2, proteins with an N-terminal lipin domain and
                     phosphatidylinositol transfer proteins; smart00775"
                     /db_xref="CDD:197870"
     CDS             1..1057
                     /gene="PITPNM1"
                     /gene_synonym="DRES9; NIR2; PITPNM; Rd9; RDGB; RDGB1;
                     RDGBA; RDGBA1"
                     /coded_by="XM_054370596.1:714..3887"
                     /db_xref="GeneID:9600"
                     /db_xref="HGNC:HGNC:9003"
                     /db_xref="MIM:608794"
ORIGIN      
        1 mcayklckve frywgmqaki eqfihdvglr rvmlrahrqa wcwqdewtel smadiralee
       61 etarmlaqrm akcntgsegs eaqppgkpst earsaasntg tpdgpeappg pdaspdasfg
      121 kqwssssrss yssqhggavs pqslsewrmq niardsenss eeeffdahgf sdseevfpke
      181 mtkwnsndfi dafaspveae gtpepgaeaa kgiedgaqap rdsegldgag elgaeacavh
      241 alflilhsgn ildsgpgdan skqadvqtls safeavtrih fpealghval rlvpcppica
      301 aayalvsnls pyshdgdsls rsqdhiplaa lpllatsssr yqgavatvia rtnqaysafl
      361 rspegagfcg qvaligdgvg gilgfdalch sanagtgsrg ssrrgsmnne llspefgpvr
      421 dpladgvegl grgspepsal ppqripsdma spepegsqns lqaapattss weprrastaf
      481 cppaasseap dgpsstarld fkvsgfflfg splglvlalr ktvmpaleaa qmrpaceqiy
      541 nlfhaadpca srlepllapk fqaiapltvp ryqkfplgdg ssllladtlq thsslfleel
      601 emlvpstpts tsgafwkgse latdppaqpa apsttsevvk ilerwwgtkr idyslycpea
      661 ltafptvtlp hlfhasywes advvafilrq viekerpqla eceepsiysp afprekwqrk
      721 rtqvkirnvt snhrasdtvv cegrpqvlsg rfmygpldvv tltgekvdvy imtqplsgkw
      781 ihfgtevtns sgrltfpvpp eralgigvyp vrmvvrgdht yaeccltvva rgteavvfsi
      841 dgsftasvsi mgsdpkvrag avdvvrhwqd sgylivyvtg rpdmqkhrvv awlsqhnfph
      901 gvvsfcdglt hdplrqkamf lqslvqevel nivagygspk dvavyaalgl spsqtyivgr
      961 avrklqaqcq flsdgyvahl gqleagshsh assgppraal gkssygvaap vdflrkqsql
     1021 lrsrgpsqae regpgtpptt largkarsis lkldsee
//
LOCUS       XP_054226572            1049 aa            linear   PRI 05-AUG-2025
DEFINITION  membrane-associated phosphatidylinositol transfer protein 1 isoform
            X7 [Homo sapiens].
ACCESSION   XP_054226572
VERSION     XP_054226572.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370597.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1049
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1049
                     /product="membrane-associated phosphatidylinositol
                     transfer protein 1 isoform X7"
                     /calculated_mol_wt=112406
     Region          <1..62
                     /region_name="SRPBCC"
                     /note="START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC)
                     ligand-binding domain superfamily; cl14643"
                     /db_xref="CDD:472699"
     Region          491..684
                     /region_name="DDHD"
                     /note="DDHD domain; pfam02862"
                     /db_xref="CDD:460725"
     Region          828..959
                     /region_name="LNS2"
                     /note="This domain is found in Saccharomyces cerevisiae
                     protein SMP2, proteins with an N-terminal lipin domain and
                     phosphatidylinositol transfer proteins; smart00775"
                     /db_xref="CDD:197870"
     CDS             1..1049
                     /gene="PITPNM1"
                     /gene_synonym="DRES9; NIR2; PITPNM; Rd9; RDGB; RDGB1;
                     RDGBA; RDGBA1"
                     /coded_by="XM_054370597.1:157..3306"
                     /db_xref="GeneID:9600"
                     /db_xref="HGNC:HGNC:9003"
                     /db_xref="MIM:608794"
ORIGIN      
        1 manyflckis lnthntppgl rrvmlrahrq awcwqdewte lsmadirale eetarmlaqr
       61 makcntgseg seaqppgkps tearsaasnt gtpdgpeapp gpdaspdasf gkqwssssrs
      121 syssqhggav spqslsewrm qniardsens seeeffdahe gfsdseevfp kemtkwnsnd
      181 fidafaspve aegtpepgae aakgiedgaq aprdsegldg agelgaeaca vhalflilhs
      241 gnildsgpgd anskqadvqt lssafeavtr ihfpealghv alrlvpcppi caaayalvsn
      301 lspyshdgds lsrsqdhipl aalpllatss sryqgavatv iartnqaysa flrspegagf
      361 cgqvaligdg vggilgfdal chsanagtgs rgssrrgsmn nellspefgp vrdpladgve
      421 glgrgspeps alppqripsd maspepegsq nslqaapatt ssweprrast afcppaasse
      481 apdgpsstar ldfkvsgffl fgsplglvla lrktvmpale aaqmrpaceq iynlfhaadp
      541 casrleplla pkfqaiaplt vpryqkfplg dgssllladt lqthsslfle elemlvpstp
      601 tstsgafwkg selatdppaq paapsttsev vkilerwwgt kridyslycp ealtafptvt
      661 lphlfhasyw esadvvafil rqviekerpq laeceepsiy spafprekwq rkrtqvkirn
      721 vtsnhrasdt vvcegrpqvl sgrfmygpld vvtltgekvd vyimtqplsg kwihfgtevt
      781 nssgrltfpv pperalgigv ypvrmvvrgd htyaeccltv vargteavvf sidgsftasv
      841 simgsdpkvr agavdvvrhw qdsgylivyv tgrpdmqkhr vvawlsqhnf phgvvsfcdg
      901 lthdplrqka mflqslvqev elnivagygs pkdvavyaal glspsqtyiv gravrklqaq
      961 cqflsdgyva hlgqleagsh shassgppra algkssygva apvdflrkqs qllrsrgpsq
     1021 aeregpgtpp ttlargkars islkldsee
//
LOCUS       XP_054226573            1048 aa            linear   PRI 05-AUG-2025
DEFINITION  membrane-associated phosphatidylinositol transfer protein 1 isoform
            X8 [Homo sapiens].
ACCESSION   XP_054226573
VERSION     XP_054226573.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370598.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1048
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1048
                     /product="membrane-associated phosphatidylinositol
                     transfer protein 1 isoform X8"
                     /calculated_mol_wt=112335
     Region          <1..62
                     /region_name="SRPBCC"
                     /note="START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC)
                     ligand-binding domain superfamily; cl14643"
                     /db_xref="CDD:472699"
     Region          491..683
                     /region_name="DDHD"
                     /note="DDHD domain; pfam02862"
                     /db_xref="CDD:460725"
     Region          827..958
                     /region_name="LNS2"
                     /note="This domain is found in Saccharomyces cerevisiae
                     protein SMP2, proteins with an N-terminal lipin domain and
                     phosphatidylinositol transfer proteins; smart00775"
                     /db_xref="CDD:197870"
     CDS             1..1048
                     /gene="PITPNM1"
                     /gene_synonym="DRES9; NIR2; PITPNM; Rd9; RDGB; RDGB1;
                     RDGBA; RDGBA1"
                     /coded_by="XM_054370598.1:157..3303"
                     /db_xref="GeneID:9600"
                     /db_xref="HGNC:HGNC:9003"
                     /db_xref="MIM:608794"
ORIGIN      
        1 manyflckis lnthntppgl rrvmlrahrq awcwqdewte lsmadirale eetarmlaqr
       61 makcntgseg seaqppgkps tearsaasnt gtpdgpeapp gpdaspdasf gkqwssssrs
      121 syssqhggav spqslsewrm qniardsens seeeffdahe gfsdseevfp kemtkwnsnd
      181 fidafaspve aegtpepgae aakgiedgaq aprdsegldg agelgaeaca vhalflilhs
      241 gnildsgpgd anskqadvqt lssafeavtr ihfpealghv alrlvpcppi caaayalvsn
      301 lspyshdgds lsrsqdhipl aalpllatss sryqgavatv iartnqaysa flrspegagf
      361 cgqvaligdg vggilgfdal chsanagtgs rgssrrgsmn nellspefgp vrdpladgve
      421 glgrgspeps alppqripsd maspepegsq nslqaapatt ssweprrast afcppaasse
      481 apdgpsstar ldfkvsgffl fgsplglvla lrktvmpale aqmrpaceqi ynlfhaadpc
      541 asrlepllap kfqaiapltv pryqkfplgd gssllladtl qthsslflee lemlvpstpt
      601 stsgafwkgs elatdppaqp aapsttsevv kilerwwgtk ridyslycpe altafptvtl
      661 phlfhasywe sadvvafilr qviekerpql aeceepsiys pafprekwqr krtqvkirnv
      721 tsnhrasdtv vcegrpqvls grfmygpldv vtltgekvdv yimtqplsgk wihfgtevtn
      781 ssgrltfpvp peralgigvy pvrmvvrgdh tyaeccltvv argteavvfs idgsftasvs
      841 imgsdpkvra gavdvvrhwq dsgylivyvt grpdmqkhrv vawlsqhnfp hgvvsfcdgl
      901 thdplrqkam flqslvqeve lnivagygsp kdvavyaalg lspsqtyivg ravrklqaqc
      961 qflsdgyvah lgqleagshs hassgppraa lgkssygvaa pvdflrkqsq llrsrgpsqa
     1021 eregpgtppt tlargkarsi slkldsee
//
LOCUS       XP_054226574             842 aa            linear   PRI 05-AUG-2025
DEFINITION  membrane-associated phosphatidylinositol transfer protein 1 isoform
            X9 [Homo sapiens].
ACCESSION   XP_054226574
VERSION     XP_054226574.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370599.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..842
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..842
                     /product="membrane-associated phosphatidylinositol
                     transfer protein 1 isoform X9"
                     /calculated_mol_wt=90404
     Region          1..257
                     /region_name="SRPBCC_PITPNM1-2_like"
                     /note="Lipid-binding SRPBCC domain of mammalian PITPNM1-2
                     and related proteins (Class IIA PITPs); cd08889"
                     /db_xref="CDD:176898"
     Site            order(21..22,25,29,32,40,59,61,63,65,68,70,73,77,81..82,
                     84,86,88,90,95,97,99,102..103,109,111,191,197,199,209,
                     217..219,222)
                     /site_type="other"
                     /note="putative lipid binding site [chemical binding]"
                     /db_xref="CDD:176898"
     Site            65..83
                     /site_type="active"
                     /note="putative lipid exchange loop [active]"
                     /db_xref="CDD:176898"
     Site            order(118..147,153..177,185..186)
                     /site_type="active"
                     /note="putatative regulatory loop [active]"
                     /db_xref="CDD:176898"
     Site            164
                     /site_type="other"
                     /note="putative PKC phosphorylation site
                     [posttranslational modification]"
                     /db_xref="CDD:176898"
     Region          606..>707
                     /region_name="SAV_2336_NTERM"
                     /note="SAV_2336 family N-terminal domain; NF041121"
                     /db_xref="CDD:469044"
     Region          686..>824
                     /region_name="DDHD"
                     /note="DDHD domain; pfam02862"
                     /db_xref="CDD:460725"
     CDS             1..842
                     /gene="PITPNM1"
                     /gene_synonym="DRES9; NIR2; PITPNM; Rd9; RDGB; RDGB1;
                     RDGBA; RDGBA1"
                     /coded_by="XM_054370599.1:218..2746"
                     /db_xref="GeneID:9600"
                     /db_xref="HGNC:HGNC:9003"
                     /db_xref="MIM:608794"
ORIGIN      
        1 mlikeyhill pmsldeyqva qlymiqkksr eessgegsgv eilanrpytd gpggsgqyth
       61 kvyhvgship gwfrallpka alqveeeswn aypytrtryt cpfvekfsie ietyylpdgg
      121 qqpnvfnlsg aerrqrildt idivrdavap geykaeedpr lyhsvktgrg plsddwarta
      181 aqtgplmcay klckvefryw gmqakieqfi hdvglrrvml rahrqawcwq dewtelsmad
      241 iraleeetar mlaqrmakcn tgsegseaqp pgkpstears aasntgtpdg peappgpdas
      301 pdasfgkqws sssrssyssq hggavspqsl sewrmqniar dsensseeef fdahegfsds
      361 eevfpkemtk wnsndfidaf aspveaegtp epgaeaakgi edgaqaprds egldgagelg
      421 aeacavhalf lilhsgnild sgpgdanskq advqtlssaf eavtrihfpe alghvalrlv
      481 pcppicaaay alvsnlspys hdgdslsrsq dhiplaalpl latsssryqg avatviartn
      541 qaysaflrsp egagfcgqva ligdgvggil gfdalchsan agtgsrgssr rgsmnnells
      601 pefgpvrdpl adgveglgrg spepsalppq ripsdmaspe pegsqnslqa apattsswep
      661 rrastafcpp aasseapdgp sstarldfkv sgfflfgspl glvlalrktv mpaleaaqmr
      721 paceqiynlf haadpcasrl epllapkfqa iapltvpryq kfplgdgssl lladtlqths
      781 slfleeleml vpstptstsg afwkgselat dppaqpaaps ttsevvkttg spptwwrssc
      841 ar
//
LOCUS       XP_054226575             740 aa            linear   PRI 05-AUG-2025
DEFINITION  membrane-associated phosphatidylinositol transfer protein 1 isoform
            X10 [Homo sapiens].
ACCESSION   XP_054226575
VERSION     XP_054226575.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370600.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..740
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..740
                     /product="membrane-associated phosphatidylinositol
                     transfer protein 1 isoform X10"
                     /calculated_mol_wt=79272
     Region          1..257
                     /region_name="SRPBCC_PITPNM1-2_like"
                     /note="Lipid-binding SRPBCC domain of mammalian PITPNM1-2
                     and related proteins (Class IIA PITPs); cd08889"
                     /db_xref="CDD:176898"
     Site            order(21..22,25,29,32,40,59,61,63,65,68,70,73,77,81..82,
                     84,86,88,90,95,97,99,102..103,109,111,191,197,199,209,
                     217..219,222)
                     /site_type="other"
                     /note="putative lipid binding site [chemical binding]"
                     /db_xref="CDD:176898"
     Site            65..83
                     /site_type="active"
                     /note="putative lipid exchange loop [active]"
                     /db_xref="CDD:176898"
     Site            order(118..147,153..177,185..186)
                     /site_type="active"
                     /note="putatative regulatory loop [active]"
                     /db_xref="CDD:176898"
     Site            164
                     /site_type="other"
                     /note="putative PKC phosphorylation site
                     [posttranslational modification]"
                     /db_xref="CDD:176898"
     Region          606..>707
                     /region_name="SAV_2336_NTERM"
                     /note="SAV_2336 family N-terminal domain; NF041121"
                     /db_xref="CDD:469044"
     Region          686..>707
                     /region_name="DDHD"
                     /note="DDHD domain; pfam02862"
                     /db_xref="CDD:460725"
     CDS             1..740
                     /gene="PITPNM1"
                     /gene_synonym="DRES9; NIR2; PITPNM; Rd9; RDGB; RDGB1;
                     RDGBA; RDGBA1"
                     /coded_by="XM_054370600.1:218..2440"
                     /db_xref="GeneID:9600"
                     /db_xref="HGNC:HGNC:9003"
                     /db_xref="MIM:608794"
ORIGIN      
        1 mlikeyhill pmsldeyqva qlymiqkksr eessgegsgv eilanrpytd gpggsgqyth
       61 kvyhvgship gwfrallpka alqveeeswn aypytrtryt cpfvekfsie ietyylpdgg
      121 qqpnvfnlsg aerrqrildt idivrdavap geykaeedpr lyhsvktgrg plsddwarta
      181 aqtgplmcay klckvefryw gmqakieqfi hdvglrrvml rahrqawcwq dewtelsmad
      241 iraleeetar mlaqrmakcn tgsegseaqp pgkpstears aasntgtpdg peappgpdas
      301 pdasfgkqws sssrssyssq hggavspqsl sewrmqniar dsensseeef fdahegfsds
      361 eevfpkemtk wnsndfidaf aspveaegtp epgaeaakgi edgaqaprds egldgagelg
      421 aeacavhalf lilhsgnild sgpgdanskq advqtlssaf eavtrihfpe alghvalrlv
      481 pcppicaaay alvsnlspys hdgdslsrsq dhiplaalpl latsssryqg avatviartn
      541 qaysaflrsp egagfcgqva ligdgvggil gfdalchsan agtgsrgssr rgsmnnells
      601 pefgpvrdpl adgveglgrg spepsalppq ripsdmaspe pegsqnslqa apattsswep
      661 rrastafcpp aasseapdgp sstarldfkv sgfflfgspl glvlalrktv mpaleglate
      721 gepeaqkegt rqgspdapsl
//
LOCUS       XP_054226576             739 aa            linear   PRI 05-AUG-2025
DEFINITION  membrane-associated phosphatidylinositol transfer protein 1 isoform
            X11 [Homo sapiens].
ACCESSION   XP_054226576
VERSION     XP_054226576.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370601.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..739
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..739
                     /product="membrane-associated phosphatidylinositol
                     transfer protein 1 isoform X11"
                     /calculated_mol_wt=79185
     Region          1..257
                     /region_name="SRPBCC_PITPNM1-2_like"
                     /note="Lipid-binding SRPBCC domain of mammalian PITPNM1-2
                     and related proteins (Class IIA PITPs); cd08889"
                     /db_xref="CDD:176898"
     Site            order(21..22,25,29,32,40,59,61,63,65,68,70,73,77,81..82,
                     84,86,88,90,95,97,99,102..103,109,111,191,197,199,209,
                     217..219,222)
                     /site_type="other"
                     /note="putative lipid binding site [chemical binding]"
                     /db_xref="CDD:176898"
     Site            65..83
                     /site_type="active"
                     /note="putative lipid exchange loop [active]"
                     /db_xref="CDD:176898"
     Site            order(118..147,153..177,185..186)
                     /site_type="active"
                     /note="putatative regulatory loop [active]"
                     /db_xref="CDD:176898"
     Site            164
                     /site_type="other"
                     /note="putative PKC phosphorylation site
                     [posttranslational modification]"
                     /db_xref="CDD:176898"
     Region          606..>707
                     /region_name="SAV_2336_NTERM"
                     /note="SAV_2336 family N-terminal domain; NF041121"
                     /db_xref="CDD:469044"
     Region          686..>707
                     /region_name="DDHD"
                     /note="DDHD domain; pfam02862"
                     /db_xref="CDD:460725"
     CDS             1..739
                     /gene="PITPNM1"
                     /gene_synonym="DRES9; NIR2; PITPNM; Rd9; RDGB; RDGB1;
                     RDGBA; RDGBA1"
                     /coded_by="XM_054370601.1:218..2437"
                     /db_xref="GeneID:9600"
                     /db_xref="HGNC:HGNC:9003"
                     /db_xref="MIM:608794"
ORIGIN      
        1 mlikeyhill pmsldeyqva qlymiqkksr eessgegsgv eilanrpytd gpggsgqyth
       61 kvyhvgship gwfrallpka alqveeeswn aypytrtryt cpfvekfsie ietyylpdgg
      121 qqpnvfnlsg aerrqrildt idivrdavap geykaeedpr lyhsvktgrg plsddwarta
      181 aqtgplmcay klckvefryw gmqakieqfi hdvglrrvml rahrqawcwq dewtelsmad
      241 iraleeetar mlaqrmakcn tgsegseaqp pgkpstears aasntgtpdg peappgpdas
      301 pdasfgkqws sssrssyssq hggavspqsl sewrmqniar dsensseeef fdahegfsds
      361 eevfpkemtk wnsndfidaf aspveaegtp epgaeaakgi edgaqaprds egldgagelg
      421 aeacavhalf lilhsgnild sgpgdanskq advqtlssaf eavtrihfpe alghvalrlv
      481 pcppicaaay alvsnlspys hdgdslsrsq dhiplaalpl latsssryqg avatviartn
      541 qaysaflrsp egagfcgqva ligdgvggil gfdalchsan agtgsrgssr rgsmnnells
      601 pefgpvrdpl adgveglgrg spepsalppq ripsdmaspe pegsqnslqa apattsswep
      661 rrastafcpp aasseapdgp sstarldfkv sgfflfgspl glvlalrktv mpaleglate
      721 gepeaqkegt rqgpdapsl
//
LOCUS       XP_054226577             722 aa            linear   PRI 05-AUG-2025
DEFINITION  ras and Rab interactor 1 isoform X1 [Homo sapiens].
ACCESSION   XP_054226577
VERSION     XP_054226577.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370602.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..722
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..722
                     /product="ras and Rab interactor 1 isoform X1"
                     /calculated_mol_wt=77468
     Region          58..158
                     /region_name="SH2_RIN1"
                     /note="Src homology 2 (SH2) domain found in Ras and Rab
                     interactor 1 (RIN1)-like proteins; cd10393"
                     /db_xref="CDD:198256"
     Site            order(76,94,119,121)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198256"
     Site            order(120,148)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198256"
     Region          429..546
                     /region_name="VPS9"
                     /note="Domain present in VPS9; smart00167"
                     /db_xref="CDD:128469"
     Region          564..644
                     /region_name="Ubl1_cv_Nsp3_N-like"
                     /note="first ubiquitin-like (Ubl) domain located at the
                     N-terminus of coronavirus SARS-CoV non-structural protein
                     3 (Nsp3) and related proteins; cl28922"
                     /db_xref="CDD:475130"
     CDS             1..722
                     /gene="RIN1"
                     /coded_by="XM_054370602.1:33..2201"
                     /db_xref="GeneID:9610"
                     /db_xref="HGNC:HGNC:18749"
                     /db_xref="MIM:605965"
ORIGIN      
        1 mespgesgag spgapspssf ttghlarekp aqdplydvpn asggqaggpq rpgrvvslre
       61 rllltrpvwl qlqanaaaal hmlrteppgt flvrksntrq cqalcmrlpe asgpsfvssh
      121 yilespggvs legselmfpd lvqlicaych trdilllplq lpraihhaat hkeleaishl
      181 giefwsssln ikaqrgpagg pvlpqlkars pqeldqgtga alcffnplfp gdlgptkrek
      241 fkrsfkvrvs tetssplspp avppppvpvl pgavpsqter lppcqllrre ssvgyrvpag
      301 sgpslppmps lqevdcgsps sseeegvpgs rgspatsphl grrrpllrsm saafcsllap
      361 erqvgraaaa lmqdrhtaag qlvqdlltqv ragpepqelq girqalsrar amlsaelgpe
      421 kllspkrlve leqvrqkllq llrtyspsaq vkrllqackl lymalrtqeg egagadeflp
      481 llslvlahcd lpellleaey msellepsll tgeggyylts lsaslallsg lgqahtlpls
      541 pvqelrrsls lweqrrlpat hcfqhllrva yqdpssgcts ktlavppeas iatlnqlcat
      601 kfrvtqpntf glflykeqgy hrlppgalah rlpttgylvy rraewpetqg avteeegsgq
      661 searsrgeeq gcqgdgdagv kasprdireq settaeggqg qaqegpaqpg epeaegsraa
      721 ee
//
LOCUS       XP_054226578             693 aa            linear   PRI 05-AUG-2025
DEFINITION  ras and Rab interactor 1 isoform X2 [Homo sapiens].
ACCESSION   XP_054226578
VERSION     XP_054226578.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370603.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..693
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..693
                     /product="ras and Rab interactor 1 isoform X2"
                     /calculated_mol_wt=74688
     Region          30..130
                     /region_name="SH2"
                     /note="Src homology 2 (SH2) domain; cl15255"
                     /db_xref="CDD:472789"
     Site            order(48,66,91,93)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198173"
     Site            order(92,119)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198173"
     Region          401..517
                     /region_name="VPS9"
                     /note="Domain present in VPS9; smart00167"
                     /db_xref="CDD:128469"
     Region          535..615
                     /region_name="Ubl1_cv_Nsp3_N-like"
                     /note="first ubiquitin-like (Ubl) domain located at the
                     N-terminus of coronavirus SARS-CoV non-structural protein
                     3 (Nsp3) and related proteins; cl28922"
                     /db_xref="CDD:475130"
     CDS             1..693
                     /gene="RIN1"
                     /coded_by="XM_054370603.1:100..2181"
                     /db_xref="GeneID:9610"
                     /db_xref="HGNC:HGNC:18749"
                     /db_xref="MIM:605965"
ORIGIN      
        1 mpaqdplydv pnasggqagg pqrpgrvvsl rerllltrpv wlqlqanaaa alhmlrtepp
       61 gtflvrksnt rqcqalcmrl peasgpsfvs shyilespgg vslegselmf pdlvqlicay
      121 chtrdilllp lqlpraihha athkeleais hlgiefwsss lnikaqrgpa ggpvlpqlka
      181 rspqeldqgt gaalcffnpl fpgdlgptkr ekfkrsfkvr vstetsspls ppavppppvp
      241 vlpgavpsqt erlppcqllr ressvgyrvp agsgpslppm pslqevdcgs pssseeegvp
      301 gsrgspatsp hlgrrrpllr smsaafcsll aperqvgraa aalmqdrhta agqlvqdllt
      361 qvragpepqe lqgirqalsr aramlsaelg pekllspkrl eleqvrqkll qllrtyspsa
      421 qvkrllqack llymalrtqe gegagadefl pllslvlahc dlpellleae ymsellepsl
      481 ltgeggyylt slsaslalls glgqahtlpl spvqelrrsl slweqrrlpa thcfqhllrv
      541 ayqdpssgct sktlavppea siatlnqlca tkfrvtqpnt fglflykeqg yhrlppgala
      601 hrlpttgylv yrraewpetq gavteeegsg qsearsrgee qgcqgdgdag vkasprdire
      661 qsettaeggq gqaqegpaqp gepeaegsra aee
//
LOCUS       XP_054226579             702 aa            linear   PRI 05-AUG-2025
DEFINITION  ras and Rab interactor 1 isoform X3 [Homo sapiens].
ACCESSION   XP_054226579
VERSION     XP_054226579.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370604.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..702
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..702
                     /product="ras and Rab interactor 1 isoform X3"
                     /calculated_mol_wt=75647
     Region          <1..77
                     /region_name="SH2"
                     /note="Src homology 2 (SH2) domain; cl15255"
                     /db_xref="CDD:472789"
     Site            order(39,66)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198173"
     Region          408..526
                     /region_name="VPS9"
                     /note="Domain present in VPS9; smart00167"
                     /db_xref="CDD:128469"
     Region          544..624
                     /region_name="Ubl1_cv_Nsp3_N-like"
                     /note="first ubiquitin-like (Ubl) domain located at the
                     N-terminus of coronavirus SARS-CoV non-structural protein
                     3 (Nsp3) and related proteins; cl28922"
                     /db_xref="CDD:475130"
     CDS             1..702
                     /gene="RIN1"
                     /coded_by="XM_054370604.1:288..2396"
                     /db_xref="GeneID:9610"
                     /db_xref="HGNC:HGNC:18749"
                     /db_xref="MIM:605965"
ORIGIN      
        1 mlrteppgtf lvrksntrqc qalcmrlpea sgpsfvsshy ilespggvsl egselmfpdl
       61 vqlicaycht rdilllplql praihhaath keleaishlg iefwssslni kaqrgpaggp
      121 vlpqlkarsp qeldqgtgaa lcffnplfpg dlgptkrekf krsfkvrvst etssplsppa
      181 vppppvpvlp gavpsqterl ppcqllrres svgyrvpags gpslppmpsl qevdcgspss
      241 seeegvpgsr gspatsphlg rrrpllrsms aafcsllape rqvgraaaal mqdrhtaagq
      301 lvqdlltqvr agpepqelqg irqalsrara mlsaelgpek llspkrlehv lekslhcsvl
      361 kplrpilaar lrrrlaadgs lgrlaeglrl araqgpgafg shlslpspve leqvrqkllq
      421 llrtyspsaq vkrllqackl lymalrtqeg egagadeflp llslvlahcd lpellleaey
      481 msellepsll tgeggyylts lsaslallsg lgqahtlpls pvqelrrsls lweqrrlpat
      541 hcfqhllrva yqdpssgcts ktlavppeas iatlnqlcat kfrvtqpntf glflykeqgy
      601 hrlppgalah rlpttgylvy rraewpetqg avteeegsgq searsrgeeq gcqgdgdagv
      661 kasprdireq settaeggqg qaqegpaqpg epeaegsraa ee
//
LOCUS       XP_054226580             519 aa            linear   PRI 05-AUG-2025
DEFINITION  tesmin isoform X1 [Homo sapiens].
ACCESSION   XP_054226580
VERSION     XP_054226580.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370605.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..519
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..519
                     /product="tesmin isoform X1"
                     /calculated_mol_wt=55917
     Region          367..404
                     /region_name="TCR"
                     /note="Tesmin/TSO1-like CXC domain, cysteine-rich domain;
                     pfam03638"
                     /db_xref="CDD:461001"
     CDS             1..519
                     /gene="TESMIN"
                     /gene_synonym="CXCDC2; MTL5; MTLT"
                     /coded_by="XM_054370605.1:141..1700"
                     /db_xref="GeneID:9633"
                     /db_xref="HGNC:HGNC:7446"
                     /db_xref="MIM:604374"
ORIGIN      
        1 meegplpggl pspedamvte llspegpfas eniglkapvk yeedefhvfk eaylgpadpk
       61 epvlhafnpa lgadckgqvk aklaggdsdg gellgeypgi pelsaledva llqapqppac
      121 nvhflssllp ahrspavlpl gawvlegash pgvrmipvei keaggtttsn npeeatlqnl
      181 laqescckfp ssqeledasc cslkkdsnpm vicqlkggtq mlcidnsrtr elkalhlvpq
      241 yqdqnnylqs dvpkpmtalv grflpastkl nlitqqlega lpsvvngsaf psgstlpgpp
      301 kitlagycdc fasgdfcnnc ncnnccnnlh hdierfkaik aclgrnpeaf qpkigkgqlg
      361 nvkpqhnkgc ncrrsgclkn ycecyeaqim cssickcigc knyeesperk tlmsmpnymq
      421 tgglegshyl pptkfsglpr fshdrrpssc iswevveatc acllaqgeea ekehcskcla
      481 eqmileefgs vghlegvqet qvqmqqrqkc gcraqalgt
//
LOCUS       XP_054226581             453 aa            linear   PRI 05-AUG-2025
DEFINITION  tesmin isoform X2 [Homo sapiens].
ACCESSION   XP_054226581
VERSION     XP_054226581.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370606.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..453
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..453
                     /product="tesmin isoform X2"
                     /calculated_mol_wt=48493
     Region          301..338
                     /region_name="TCR"
                     /note="Tesmin/TSO1-like CXC domain, cysteine-rich domain;
                     pfam03638"
                     /db_xref="CDD:461001"
     CDS             1..453
                     /gene="TESMIN"
                     /gene_synonym="CXCDC2; MTL5; MTLT"
                     /coded_by="XM_054370606.1:141..1502"
                     /db_xref="GeneID:9633"
                     /db_xref="HGNC:HGNC:7446"
                     /db_xref="MIM:604374"
ORIGIN      
        1 meegplpggl pspedamvte llspegpfas eniglkapvk yeedefhvfk eaylgpadpk
       61 epvlhafnpa lgadckgqvk aklaggdsdg gellgeypgi pelsaledva llqapqppac
      121 nvhflssllp ahrspavlpl gawvlegash pgvrmipvei keaggtttsn npeeatlqnl
      181 laqescckfp ssqeledasc cslkkdsnpm legalpsvvn gsafpsgstl pgppkitlag
      241 ycdcfasgdf cnncncnncc nnlhhdierf kaikaclgrn peafqpkigk gqlgnvkpqh
      301 nkgcncrrsg clknycecye aqimcssick cigcknyees perktlmsmp nymqtggleg
      361 shylpptkfs glprfshdrr pssciswevv eatcacllaq geeaekehcs kclaeqmile
      421 efgsvghleg vqetqvqmqq rqkcgcraqa lgt
//
LOCUS       XP_054226582             445 aa            linear   PRI 05-AUG-2025
DEFINITION  tesmin isoform X3 [Homo sapiens].
ACCESSION   XP_054226582
VERSION     XP_054226582.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370607.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..445
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..445
                     /product="tesmin isoform X3"
                     /calculated_mol_wt=47764
     Region          301..338
                     /region_name="TCR"
                     /note="Tesmin/TSO1-like CXC domain, cysteine-rich domain;
                     pfam03638"
                     /db_xref="CDD:461001"
     CDS             1..445
                     /gene="TESMIN"
                     /gene_synonym="CXCDC2; MTL5; MTLT"
                     /coded_by="XM_054370607.1:141..1478"
                     /db_xref="GeneID:9633"
                     /db_xref="HGNC:HGNC:7446"
                     /db_xref="MIM:604374"
ORIGIN      
        1 meegplpggl pspedamvte llspegpfas eniglkapvk yeedefhvfk eaylgpadpk
       61 epvlhafnpa lgadckgqvk aklaggdsdg gellgeypgi pelsaledva llqapqppac
      121 nvhflssllp ahrspavlpl gawvlegash pgvrmipvei keaggtttsn npeeatlqnl
      181 laqescckfp ssqeledasc cslkkdsnpm legalpsvvn gsafpsgstl pgppkitlag
      241 ycdcfasgdf cnncncnncc nnlhhdierf kaikaclgrn peafqpkigk gqlgnvkpqh
      301 nkgcncrrsg clknycecye aqimcssick cigcknyees perktlmsmp nymqtggleg
      361 shylpptkfs glprfshdrr pssciswevv eatcacllaq geeaekehcs kclaeqmile
      421 efgrnkfsgw avviplkisr ellnt
//
LOCUS       XP_054226583             364 aa            linear   PRI 05-AUG-2025
DEFINITION  tesmin isoform X4 [Homo sapiens].
ACCESSION   XP_054226583
VERSION     XP_054226583.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370608.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..364
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..364
                     /product="tesmin isoform X4"
                     /calculated_mol_wt=38637
     CDS             1..364
                     /gene="TESMIN"
                     /gene_synonym="CXCDC2; MTL5; MTLT"
                     /coded_by="XM_054370608.1:141..1235"
                     /db_xref="GeneID:9633"
                     /db_xref="HGNC:HGNC:7446"
                     /db_xref="MIM:604374"
ORIGIN      
        1 meegplpggl pspedamvte llspegpfas eniglkapvk yeedefhvfk eaylgpadpk
       61 epvlhafnpa lgadckgqvk aklaggdsdg gellgeypgi pelsaledva llqapqppac
      121 nvhflssllp ahrspavlpl gawvlegash pgvrmipvei keaggtttsn npeeatlqnl
      181 laqescckfp ssqeledasc cslkkdsnpm vicqlkggtq mlcidnsrtr elkalhlvpq
      241 yqdqnnylqs dvpkpmtalv grflpastkl nlitqqlega lpsvvngsaf psgstlpgpp
      301 kitlagleyn gmisahcnlr llgssnspss asrvagttga yhytrlifvf fsrdwvlpcw
      361 pgws
//
LOCUS       XP_054226584             298 aa            linear   PRI 05-AUG-2025
DEFINITION  tesmin isoform X5 [Homo sapiens].
ACCESSION   XP_054226584
VERSION     XP_054226584.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370609.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..298
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..298
                     /product="tesmin isoform X5"
                     /calculated_mol_wt=31213
     CDS             1..298
                     /gene="TESMIN"
                     /gene_synonym="CXCDC2; MTL5; MTLT"
                     /coded_by="XM_054370609.1:141..1037"
                     /db_xref="GeneID:9633"
                     /db_xref="HGNC:HGNC:7446"
                     /db_xref="MIM:604374"
ORIGIN      
        1 meegplpggl pspedamvte llspegpfas eniglkapvk yeedefhvfk eaylgpadpk
       61 epvlhafnpa lgadckgqvk aklaggdsdg gellgeypgi pelsaledva llqapqppac
      121 nvhflssllp ahrspavlpl gawvlegash pgvrmipvei keaggtttsn npeeatlqnl
      181 laqescckfp ssqeledasc cslkkdsnpm legalpsvvn gsafpsgstl pgppkitlag
      241 leyngmisah cnlrllgssn spssasrvag ttgayhytrl ifvffsrdwv lpcwpgws
//
LOCUS       XP_054226585             243 aa            linear   PRI 05-AUG-2025
DEFINITION  tesmin isoform X6 [Homo sapiens].
ACCESSION   XP_054226585
VERSION     XP_054226585.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370610.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..243
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..243
                     /product="tesmin isoform X6"
                     /calculated_mol_wt=25083
     CDS             1..243
                     /gene="TESMIN"
                     /gene_synonym="CXCDC2; MTL5; MTLT"
                     /coded_by="XM_054370610.1:141..872"
                     /db_xref="GeneID:9633"
                     /db_xref="HGNC:HGNC:7446"
                     /db_xref="MIM:604374"
ORIGIN      
        1 meegplpggl pspedamvte llspegpfas eniglkapvk yeedefhvfk eaylgpadpk
       61 epvlhafnpa lgadckgqvk aklaggdsdg gellgeypgi pelsaledva llqapqppac
      121 nvhflssllp ahrspavlpl gawvlegash pgvrmipvei keaggtttsn npeeatlqnl
      181 laqescckfp ssqeledasc cslkkdsnpm legalpsvvn gsafpsgstl pgppkitlag
      241 kct
//
LOCUS       XP_054226586             392 aa            linear   PRI 05-AUG-2025
DEFINITION  fasciculation and elongation protein zeta-1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_054226586
VERSION     XP_054226586.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370611.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 9% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..392
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..392
                     /product="fasciculation and elongation protein zeta-1
                     isoform X1"
                     /calculated_mol_wt=44988
     Region          58..297
                     /region_name="FEZ"
                     /note="FEZ-like protein; pfam07763"
                     /db_xref="CDD:462257"
     CDS             1..392
                     /gene="FEZ1"
                     /gene_synonym="UNC-76"
                     /coded_by="XM_054370611.1:412..1590"
                     /db_xref="GeneID:9638"
                     /db_xref="HGNC:HGNC:3659"
                     /db_xref="MIM:604825"
ORIGIN      
        1 meaplvslde efedlrpscs edpeekpqcf ygssphhled pslselenfs seiisfksme
       61 dlvnefdekl nvcfrnynak tenlapvknq lqiqeeeetl qdeevwdalt dnyipslsed
      121 wrdpniealn gncsdteihe keeeefneks endsgineep lltadqviee ieemmqnspd
      181 peeeeevlee edggetssqa dsvllqemqa ltqtfnnnws yeglrhmsgs eltelldqve
      241 gairdfseel vqqlarrdel efekevknsf itvlievqnk qkeqrelmkk rrkekglslq
      301 ssriekgnqm plkrfsmegi snilqsgirq tfgssgtdkq ylntvipyek kasppsvedl
      361 qmltnilfam kednekvptl ltdyilkvlc pt
//
LOCUS       XP_054226587             392 aa            linear   PRI 05-AUG-2025
DEFINITION  fasciculation and elongation protein zeta-1 isoform X1 [Homo
            sapiens].
ACCESSION   XP_054226587
VERSION     XP_054226587.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370612.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 9% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..392
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..392
                     /product="fasciculation and elongation protein zeta-1
                     isoform X1"
                     /calculated_mol_wt=44988
     Region          58..297
                     /region_name="FEZ"
                     /note="FEZ-like protein; pfam07763"
                     /db_xref="CDD:462257"
     CDS             1..392
                     /gene="FEZ1"
                     /gene_synonym="UNC-76"
                     /coded_by="XM_054370612.1:481..1659"
                     /db_xref="GeneID:9638"
                     /db_xref="HGNC:HGNC:3659"
                     /db_xref="MIM:604825"
ORIGIN      
        1 meaplvslde efedlrpscs edpeekpqcf ygssphhled pslselenfs seiisfksme
       61 dlvnefdekl nvcfrnynak tenlapvknq lqiqeeeetl qdeevwdalt dnyipslsed
      121 wrdpniealn gncsdteihe keeeefneks endsgineep lltadqviee ieemmqnspd
      181 peeeeevlee edggetssqa dsvllqemqa ltqtfnnnws yeglrhmsgs eltelldqve
      241 gairdfseel vqqlarrdel efekevknsf itvlievqnk qkeqrelmkk rrkekglslq
      301 ssriekgnqm plkrfsmegi snilqsgirq tfgssgtdkq ylntvipyek kasppsvedl
      361 qmltnilfam kednekvptl ltdyilkvlc pt
//
LOCUS       XP_054226588             491 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 57 kDa isoform X1 [Homo sapiens].
ACCESSION   XP_054226588
VERSION     XP_054226588.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370613.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..491
                     /product="centrosomal protein of 57 kDa isoform X1"
                     /calculated_mol_wt=56260
     Region          59..235
                     /region_name="Cep57_CLD"
                     /note="Centrosome localization domain of Cep57; pfam14073"
                     /db_xref="CDD:464080"
     Region          339..412
                     /region_name="Cep57_MT_bd"
                     /note="Centrosome microtubule-binding domain of Cep57;
                     pfam06657"
                     /db_xref="CDD:461976"
     CDS             1..491
                     /gene="CEP57"
                     /gene_synonym="MVA2; PIG8; TSP57"
                     /coded_by="XM_054370613.1:340..1815"
                     /db_xref="GeneID:9702"
                     /db_xref="HGNC:HGNC:30794"
                     /db_xref="MIM:607951"
ORIGIN      
        1 mltridnsfa epsrsngsmv rhssspyvvy psdkpflnsd lrrspskptl aypesnsrai
       61 fsalknlqdk irrleleriq aeesvktlsr etieykkvld eqiqerensk neeskhnqel
      121 tsqllaaenk cnllekqley mrnmikhaem ertsvlekqv slererqhdq thvqsqlekl
      181 dlleqeynkl ttmqalaekk mqeleaklhe eeqerkrmqa kaaelqtgle tnrlifedka
      241 tpcvpnarri kkkkskppek kssrnyfgaq phyrlclgdm pfvagkstsp shavvanvql
      301 vlhlmkqhsk alcndrvins iplakqvssr ggkskklsvt ppssnginee lsevlqtlqd
      361 efgqmsfdhq qlakliqesp tvelkdklec elealvgrme akanqitkvr kyqaqlekqk
      421 lekqkkelka tkktldeegn sssrsgitgt tnkkdfmklr pgekrrknlq llkdmqsiqn
      481 slqssslcwd y
//
LOCUS       XP_054226593             250 aa            linear   PRI 05-AUG-2025
DEFINITION  centrosomal protein of 57 kDa isoform X6 [Homo sapiens].
ACCESSION   XP_054226593
VERSION     XP_054226593.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370618.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..250
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..250
                     /product="centrosomal protein of 57 kDa isoform X6"
                     /calculated_mol_wt=28029
     Region          98..171
                     /region_name="Cep57_MT_bd"
                     /note="Centrosome microtubule-binding domain of Cep57;
                     pfam06657"
                     /db_xref="CDD:461976"
     CDS             1..250
                     /gene="CEP57"
                     /gene_synonym="MVA2; PIG8; TSP57"
                     /coded_by="XM_054370618.1:351..1103"
                     /db_xref="GeneID:9702"
                     /db_xref="HGNC:HGNC:30794"
                     /db_xref="MIM:607951"
ORIGIN      
        1 mltstirswl viimptidkk ssrnyfgaqp hyrlclgdmp fvagkstsps havvanvqlv
       61 lhlmkqhska lcndrvinsi plakqvssrg gkskklsvtp pssngineel sevlqtlqde
      121 fgqmsfdhqq lakliqespt velkdklece lealvgrmea kanqitkvrk yqaqlekqkl
      181 ekqkkelkat kktldeegns ssrsgitgtt nkkdfmklrp gekrrknlql lkdmqsiqns
      241 lqssslcwdy
//
LOCUS       XP_054226594            2074 aa            linear   PRI 05-AUG-2025
DEFINITION  rho GTPase-activating protein 32 isoform X1 [Homo sapiens].
ACCESSION   XP_054226594
VERSION     XP_054226594.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370619.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2074
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2074
                     /product="rho GTPase-activating protein 32 isoform X1"
                     /calculated_mol_wt=228594
     Region          114..228
                     /region_name="PX_RICS"
                     /note="The phosphoinositide binding Phox Homology domain
                     of PX-RICS; cd07298"
                     /db_xref="CDD:132831"
     Site            order(159..161,187..188,198)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:132831"
     Region          250..303
                     /region_name="SH3_ARHGAP32_33"
                     /note="Src homology 3 domain of Rho GTPase-activating
                     proteins 32 and 33, and similar proteins; cd11835"
                     /db_xref="CDD:212769"
     Site            order(255,257,260,264,285..286,299,301..302)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212769"
     Region          355..549
                     /region_name="RhoGAP_CdGAP"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain of CdGAP-like proteins; CdGAP
                     contains an N-terminal RhoGAP domain and a C-terminal
                     proline-rich region, and it is active on both Cdc42 and
                     Rac1 but not RhoA. CdGAP is recruited to...; cd04384"
                     /db_xref="CDD:239849"
     Site            order(394,434,438,507,510..511,540)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239849"
     Site            394
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239849"
     Region          696..1068
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     CDS             1..2074
                     /gene="ARHGAP32"
                     /gene_synonym="GC-GAP; GRIT; p200RhoGAP; p250GAP; PX-RICS;
                     RICS"
                     /coded_by="XM_054370619.1:5..6229"
                     /db_xref="GeneID:9743"
                     /db_xref="HGNC:HGNC:17399"
                     /db_xref="MIM:608541"
ORIGIN      
        1 mytlesglig kkllaqwqrf srqallhslw iylwvmfpst vqsvvvaear gadvpeipgd
       61 ltlktcgsta smkvkhvkks ttpglmgcdn ihrlpftkgh fpkmaecahf hyenvefgsi
      121 qlslseeqne vmkngceske lvylvqiacq gkswivkrsy edfrvldkhl hlciydrrfs
      181 qlselprsdt lkdspesvtq mlmaylsrls aiagnkincg paltwmeidn kgnhllvhee
      241 ssintpavga ahvikrytar apdeltlevg divsvidmpp kvlstwwrgk hgfqvglfpg
      301 hcvelinqkv pqsvtnsvpk pvskkhgkli tflrtfmksr ptkqklkqrg ilkervfgcd
      361 lgehllnsgf evpqvlqsct afierygivd giyrlsgvas niqrlrhefd sehvpdltke
      421 pyvqdihsvg slcklyfrel pnplltyqly ekfsdavsaa tdeerlikih dviqqlppph
      481 yrtleflmrh lslladycsi tnmhaknlai vwapnllrsk qiesacfsgt aafmevriqs
      541 vvvefilnhv dvlfsgrism amqegaasls rpksllvssp stklltleea qartqaqvns
      601 pivtenkyie vgegpaalqg kfhtiiefpl erkrpqnkmk kspvgswrsf fnlgksssvs
      661 krklqrnese psemkamalk ggraegtlrs akseesltsl havdgdsklf rprrprsssd
      721 alsasfngem lgnrcnsydn lphdneseee ggllhipalm sphsaedvdl sppdigvasl
      781 dfdpmsfqcs ppkaesecle sgasfldspg yskdkpsank kdaetgssqc qtpgstasse
      841 pvsplqekls pfftldlspt edksskpssf tekvvyafsp kigrklsksp smsisepisv
      901 tlpprvsevi gtvsnttaqn assstwdkcv eerdatnrsp tqivkmktne tvaqeayese
      961 vqpldqvaae evelpgkedq svsssqskav asgqtqtgav thdppqdsvp vssvslippp
     1021 pppknvarml alalaesaqq astqslkrpg tsqagytnyg diavattedn lsssysaval
     1081 dkayfqtdrp aeqfhlqnna pgncdhplpe ttatgdpths nttesgeqhh qvdltgnqph
     1141 qaylsgdpek aritsvplds eksddhvsfp edqsgknsmp tvsfldqdqs pprfysgdqp
     1201 psylgasvdk lhhplefadk sptppnlpsd kiyppsgspe entstatmty mtttpataqm
     1261 stkeaswdva eqpttadfaa atlqrthrtn rplppppsqr saeqppvvgq vqaatnigln
     1321 nshkvqgvvp vperppepra mddpasafis dsgaaaaqcp matavqpglp ekvrdgarvp
     1381 llhlraesvp ahpcgfpapl pptrmmeskm iaaihsssad atsssnyhsf vtasstsvdd
     1441 alplplpvpq pkhasqktvy ssfarpdvtt epfgpdnclh fnmtpncqyr pqsvpphhnk
     1501 leqhqvygar seppasmglr yntyvapgrn asghhskpcs rveyvsslss svrntcyped
     1561 ippyptirrv qslhappssm irsvpisrte vppddepayc prplyqykpy qssqarsdyh
     1621 vtqlqpyfen grvhyryspy ssssssyysp dgalcdvday gtvqlrplhr lpnrdfafyn
     1681 prlqgkslys yaglaprpra nvtgyfspnd hnvvsmppaa dvkhtytswd ledmekyrmq
     1741 sirresrarq kvkgpvmsqy dnmtpavqdd lggiyvihlr sksdpgktgl lsvaegkesr
     1801 haakaispeg edrfyrrhpe aemdrahhhg ghgstqpekp slpqkqsslr srklpdmgcs
     1861 lpehrahqea shrqfceskn gppypqgagq ldygskgipd tsepvsyhns gvkyaasgqe
     1921 slrlnhkevr lskemerpwv rqpsapekhs rdcykeeehl tqsivpppkp ershslklhh
     1981 tqnverdpsv lyqyqphgkr qssvtvvsqy dnledyhslp qhqrgvfggg gmgtyvppgf
     2041 phpqsrtyat algqgaflpa elslqhpetq ihae
//
LOCUS       XP_054226595            2061 aa            linear   PRI 05-AUG-2025
DEFINITION  rho GTPase-activating protein 32 isoform X2 [Homo sapiens].
ACCESSION   XP_054226595
VERSION     XP_054226595.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370620.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2061
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2061
                     /product="rho GTPase-activating protein 32 isoform X2"
                     /calculated_mol_wt=227160
     Region          101..215
                     /region_name="PX_RICS"
                     /note="The phosphoinositide binding Phox Homology domain
                     of PX-RICS; cd07298"
                     /db_xref="CDD:132831"
     Site            order(146..148,174..175,185)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:132831"
     Region          237..290
                     /region_name="SH3_ARHGAP32_33"
                     /note="Src homology 3 domain of Rho GTPase-activating
                     proteins 32 and 33, and similar proteins; cd11835"
                     /db_xref="CDD:212769"
     Site            order(242,244,247,251,272..273,286,288..289)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212769"
     Region          342..536
                     /region_name="RhoGAP_CdGAP"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain of CdGAP-like proteins; CdGAP
                     contains an N-terminal RhoGAP domain and a C-terminal
                     proline-rich region, and it is active on both Cdc42 and
                     Rac1 but not RhoA. CdGAP is recruited to...; cd04384"
                     /db_xref="CDD:239849"
     Site            order(381,421,425,494,497..498,527)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239849"
     Site            381
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239849"
     Region          683..1055
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     CDS             1..2061
                     /gene="ARHGAP32"
                     /gene_synonym="GC-GAP; GRIT; p200RhoGAP; p250GAP; PX-RICS;
                     RICS"
                     /coded_by="XM_054370620.1:101..6286"
                     /db_xref="GeneID:9743"
                     /db_xref="HGNC:HGNC:17399"
                     /db_xref="MIM:608541"
ORIGIN      
        1 mkssvhseed dfvpelhrnv hprerpdwee tlsamargad vpeipgdltl ktcgstasmk
       61 vkhvkksttp glmgcdnihr lpftkghfpk maecahfhye nvefgsiqls lseeqnevmk
      121 ngceskelvy lvqiacqgks wivkrsyedf rvldkhlhlc iydrrfsqls elprsdtlkd
      181 spesvtqmlm aylsrlsaia gnkincgpal twmeidnkgn hllvheessi ntpavgaahv
      241 ikrytarapd eltlevgdiv svidmppkvl stwwrgkhgf qvglfpghcv elinqkvpqs
      301 vtnsvpkpvs kkhgklitfl rtfmksrptk qklkqrgilk ervfgcdlge hllnsgfevp
      361 qvlqsctafi erygivdgiy rlsgvasniq rlrhefdseh vpdltkepyv qdihsvgslc
      421 klyfrelpnp lltyqlyekf sdavsaatde erlikihdvi qqlppphyrt leflmrhlsl
      481 ladycsitnm haknlaivwa pnllrskqie sacfsgtaaf mevriqsvvv efilnhvdvl
      541 fsgrismamq egaaslsrpk sllvsspstk lltleeaqar tqaqvnspiv tenkyievge
      601 gpaalqgkfh tiiefplerk rpqnkmkksp vgswrsffnl gksssvskrk lqrnesepse
      661 mkamalkggr aegtlrsaks eesltslhav dgdsklfrpr rprsssdals asfngemlgn
      721 rcnsydnlph dneseeeggl lhipalmsph saedvdlspp digvasldfd pmsfqcsppk
      781 aeseclesga sfldspgysk dkpsankkda etgssqcqtp gstassepvs plqeklspff
      841 tldlsptedk sskpssftek vvyafspkig rklskspsms isepisvtlp prvsevigtv
      901 snttaqnass stwdkcveer datnrsptqi vkmktnetva qeayesevqp ldqvaaeeve
      961 lpgkedqsvs ssqskavasg qtqtgavthd ppqdsvpvss vslipppppp knvarmlala
     1021 laesaqqast qslkrpgtsq agytnygdia vattednlss sysavaldka yfqtdrpaeq
     1081 fhlqnnapgn cdhplpetta tgdpthsntt esgeqhhqvd ltgnqphqay lsgdpekari
     1141 tsvpldseks ddhvsfpedq sgknsmptvs fldqdqsppr fysgdqppsy lgasvdklhh
     1201 plefadkspt ppnlpsdkiy ppsgspeent statmtymtt tpataqmstk easwdvaeqp
     1261 ttadfaaatl qrthrtnrpl ppppsqrsae qppvvgqvqa atniglnnsh kvqgvvpvpe
     1321 rppepramdd pasafisdsg aaaaqcpmat avqpglpekv rdgarvpllh lraesvpahp
     1381 cgfpaplppt rmmeskmiaa ihsssadats ssnyhsfvta sstsvddalp lplpvpqpkh
     1441 asqktvyssf arpdvttepf gpdnclhfnm tpncqyrpqs vpphhnkleq hqvygarsep
     1501 pasmglrynt yvapgrnasg hhskpcsrve yvsslsssvr ntcypedipp yptirrvqsl
     1561 happssmirs vpisrtevpp ddepaycprp lyqykpyqss qarsdyhvtq lqpyfengrv
     1621 hyryspysss sssyyspdga lcdvdaygtv qlrplhrlpn rdfafynprl qgkslysyag
     1681 laprpranvt gyfspndhnv vsmppaadvk htytswdled mekyrmqsir resrarqkvk
     1741 gpvmsqydnm tpavqddlgg iyvihlrsks dpgktgllsv aegkesrhaa kaispegedr
     1801 fyrrhpeaem drahhhgghg stqpekpslp qkqsslrsrk lpdmgcslpe hrahqeashr
     1861 qfceskngpp ypqgagqldy gskgipdtse pvsyhnsgvk yaasgqeslr lnhkevrlsk
     1921 emerpwvrqp sapekhsrdc ykeeehltqs ivpppkpers hslklhhtqn verdpsvlyq
     1981 yqphgkrqss vtvvsqydnl edyhslpqhq rgvfggggmg tyvppgfphp qsrtyatalg
     2041 qgaflpaels lqhpetqiha e
//
LOCUS       XP_054226596            2061 aa            linear   PRI 05-AUG-2025
DEFINITION  rho GTPase-activating protein 32 isoform X2 [Homo sapiens].
ACCESSION   XP_054226596
VERSION     XP_054226596.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370621.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2061
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2061
                     /product="rho GTPase-activating protein 32 isoform X2"
                     /calculated_mol_wt=227160
     Region          101..215
                     /region_name="PX_RICS"
                     /note="The phosphoinositide binding Phox Homology domain
                     of PX-RICS; cd07298"
                     /db_xref="CDD:132831"
     Site            order(146..148,174..175,185)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:132831"
     Region          237..290
                     /region_name="SH3_ARHGAP32_33"
                     /note="Src homology 3 domain of Rho GTPase-activating
                     proteins 32 and 33, and similar proteins; cd11835"
                     /db_xref="CDD:212769"
     Site            order(242,244,247,251,272..273,286,288..289)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212769"
     Region          342..536
                     /region_name="RhoGAP_CdGAP"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain of CdGAP-like proteins; CdGAP
                     contains an N-terminal RhoGAP domain and a C-terminal
                     proline-rich region, and it is active on both Cdc42 and
                     Rac1 but not RhoA. CdGAP is recruited to...; cd04384"
                     /db_xref="CDD:239849"
     Site            order(381,421,425,494,497..498,527)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239849"
     Site            381
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239849"
     Region          683..1055
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     CDS             1..2061
                     /gene="ARHGAP32"
                     /gene_synonym="GC-GAP; GRIT; p200RhoGAP; p250GAP; PX-RICS;
                     RICS"
                     /coded_by="XM_054370621.1:30..6215"
                     /db_xref="GeneID:9743"
                     /db_xref="HGNC:HGNC:17399"
                     /db_xref="MIM:608541"
ORIGIN      
        1 mkssvhseed dfvpelhrnv hprerpdwee tlsamargad vpeipgdltl ktcgstasmk
       61 vkhvkksttp glmgcdnihr lpftkghfpk maecahfhye nvefgsiqls lseeqnevmk
      121 ngceskelvy lvqiacqgks wivkrsyedf rvldkhlhlc iydrrfsqls elprsdtlkd
      181 spesvtqmlm aylsrlsaia gnkincgpal twmeidnkgn hllvheessi ntpavgaahv
      241 ikrytarapd eltlevgdiv svidmppkvl stwwrgkhgf qvglfpghcv elinqkvpqs
      301 vtnsvpkpvs kkhgklitfl rtfmksrptk qklkqrgilk ervfgcdlge hllnsgfevp
      361 qvlqsctafi erygivdgiy rlsgvasniq rlrhefdseh vpdltkepyv qdihsvgslc
      421 klyfrelpnp lltyqlyekf sdavsaatde erlikihdvi qqlppphyrt leflmrhlsl
      481 ladycsitnm haknlaivwa pnllrskqie sacfsgtaaf mevriqsvvv efilnhvdvl
      541 fsgrismamq egaaslsrpk sllvsspstk lltleeaqar tqaqvnspiv tenkyievge
      601 gpaalqgkfh tiiefplerk rpqnkmkksp vgswrsffnl gksssvskrk lqrnesepse
      661 mkamalkggr aegtlrsaks eesltslhav dgdsklfrpr rprsssdals asfngemlgn
      721 rcnsydnlph dneseeeggl lhipalmsph saedvdlspp digvasldfd pmsfqcsppk
      781 aeseclesga sfldspgysk dkpsankkda etgssqcqtp gstassepvs plqeklspff
      841 tldlsptedk sskpssftek vvyafspkig rklskspsms isepisvtlp prvsevigtv
      901 snttaqnass stwdkcveer datnrsptqi vkmktnetva qeayesevqp ldqvaaeeve
      961 lpgkedqsvs ssqskavasg qtqtgavthd ppqdsvpvss vslipppppp knvarmlala
     1021 laesaqqast qslkrpgtsq agytnygdia vattednlss sysavaldka yfqtdrpaeq
     1081 fhlqnnapgn cdhplpetta tgdpthsntt esgeqhhqvd ltgnqphqay lsgdpekari
     1141 tsvpldseks ddhvsfpedq sgknsmptvs fldqdqsppr fysgdqppsy lgasvdklhh
     1201 plefadkspt ppnlpsdkiy ppsgspeent statmtymtt tpataqmstk easwdvaeqp
     1261 ttadfaaatl qrthrtnrpl ppppsqrsae qppvvgqvqa atniglnnsh kvqgvvpvpe
     1321 rppepramdd pasafisdsg aaaaqcpmat avqpglpekv rdgarvpllh lraesvpahp
     1381 cgfpaplppt rmmeskmiaa ihsssadats ssnyhsfvta sstsvddalp lplpvpqpkh
     1441 asqktvyssf arpdvttepf gpdnclhfnm tpncqyrpqs vpphhnkleq hqvygarsep
     1501 pasmglrynt yvapgrnasg hhskpcsrve yvsslsssvr ntcypedipp yptirrvqsl
     1561 happssmirs vpisrtevpp ddepaycprp lyqykpyqss qarsdyhvtq lqpyfengrv
     1621 hyryspysss sssyyspdga lcdvdaygtv qlrplhrlpn rdfafynprl qgkslysyag
     1681 laprpranvt gyfspndhnv vsmppaadvk htytswdled mekyrmqsir resrarqkvk
     1741 gpvmsqydnm tpavqddlgg iyvihlrsks dpgktgllsv aegkesrhaa kaispegedr
     1801 fyrrhpeaem drahhhgghg stqpekpslp qkqsslrsrk lpdmgcslpe hrahqeashr
     1861 qfceskngpp ypqgagqldy gskgipdtse pvsyhnsgvk yaasgqeslr lnhkevrlsk
     1921 emerpwvrqp sapekhsrdc ykeeehltqs ivpppkpers hslklhhtqn verdpsvlyq
     1981 yqphgkrqss vtvvsqydnl edyhslpqhq rgvfggggmg tyvppgfphp qsrtyatalg
     2041 qgaflpaels lqhpetqiha e
//
LOCUS       XP_054226597            2061 aa            linear   PRI 05-AUG-2025
DEFINITION  rho GTPase-activating protein 32 isoform X2 [Homo sapiens].
ACCESSION   XP_054226597
VERSION     XP_054226597.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370622.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2061
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2061
                     /product="rho GTPase-activating protein 32 isoform X2"
                     /calculated_mol_wt=227160
     Region          101..215
                     /region_name="PX_RICS"
                     /note="The phosphoinositide binding Phox Homology domain
                     of PX-RICS; cd07298"
                     /db_xref="CDD:132831"
     Site            order(146..148,174..175,185)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:132831"
     Region          237..290
                     /region_name="SH3_ARHGAP32_33"
                     /note="Src homology 3 domain of Rho GTPase-activating
                     proteins 32 and 33, and similar proteins; cd11835"
                     /db_xref="CDD:212769"
     Site            order(242,244,247,251,272..273,286,288..289)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212769"
     Region          342..536
                     /region_name="RhoGAP_CdGAP"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain of CdGAP-like proteins; CdGAP
                     contains an N-terminal RhoGAP domain and a C-terminal
                     proline-rich region, and it is active on both Cdc42 and
                     Rac1 but not RhoA. CdGAP is recruited to...; cd04384"
                     /db_xref="CDD:239849"
     Site            order(381,421,425,494,497..498,527)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239849"
     Site            381
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239849"
     Region          683..1055
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     CDS             1..2061
                     /gene="ARHGAP32"
                     /gene_synonym="GC-GAP; GRIT; p200RhoGAP; p250GAP; PX-RICS;
                     RICS"
                     /coded_by="XM_054370622.1:312..6497"
                     /db_xref="GeneID:9743"
                     /db_xref="HGNC:HGNC:17399"
                     /db_xref="MIM:608541"
ORIGIN      
        1 mkssvhseed dfvpelhrnv hprerpdwee tlsamargad vpeipgdltl ktcgstasmk
       61 vkhvkksttp glmgcdnihr lpftkghfpk maecahfhye nvefgsiqls lseeqnevmk
      121 ngceskelvy lvqiacqgks wivkrsyedf rvldkhlhlc iydrrfsqls elprsdtlkd
      181 spesvtqmlm aylsrlsaia gnkincgpal twmeidnkgn hllvheessi ntpavgaahv
      241 ikrytarapd eltlevgdiv svidmppkvl stwwrgkhgf qvglfpghcv elinqkvpqs
      301 vtnsvpkpvs kkhgklitfl rtfmksrptk qklkqrgilk ervfgcdlge hllnsgfevp
      361 qvlqsctafi erygivdgiy rlsgvasniq rlrhefdseh vpdltkepyv qdihsvgslc
      421 klyfrelpnp lltyqlyekf sdavsaatde erlikihdvi qqlppphyrt leflmrhlsl
      481 ladycsitnm haknlaivwa pnllrskqie sacfsgtaaf mevriqsvvv efilnhvdvl
      541 fsgrismamq egaaslsrpk sllvsspstk lltleeaqar tqaqvnspiv tenkyievge
      601 gpaalqgkfh tiiefplerk rpqnkmkksp vgswrsffnl gksssvskrk lqrnesepse
      661 mkamalkggr aegtlrsaks eesltslhav dgdsklfrpr rprsssdals asfngemlgn
      721 rcnsydnlph dneseeeggl lhipalmsph saedvdlspp digvasldfd pmsfqcsppk
      781 aeseclesga sfldspgysk dkpsankkda etgssqcqtp gstassepvs plqeklspff
      841 tldlsptedk sskpssftek vvyafspkig rklskspsms isepisvtlp prvsevigtv
      901 snttaqnass stwdkcveer datnrsptqi vkmktnetva qeayesevqp ldqvaaeeve
      961 lpgkedqsvs ssqskavasg qtqtgavthd ppqdsvpvss vslipppppp knvarmlala
     1021 laesaqqast qslkrpgtsq agytnygdia vattednlss sysavaldka yfqtdrpaeq
     1081 fhlqnnapgn cdhplpetta tgdpthsntt esgeqhhqvd ltgnqphqay lsgdpekari
     1141 tsvpldseks ddhvsfpedq sgknsmptvs fldqdqsppr fysgdqppsy lgasvdklhh
     1201 plefadkspt ppnlpsdkiy ppsgspeent statmtymtt tpataqmstk easwdvaeqp
     1261 ttadfaaatl qrthrtnrpl ppppsqrsae qppvvgqvqa atniglnnsh kvqgvvpvpe
     1321 rppepramdd pasafisdsg aaaaqcpmat avqpglpekv rdgarvpllh lraesvpahp
     1381 cgfpaplppt rmmeskmiaa ihsssadats ssnyhsfvta sstsvddalp lplpvpqpkh
     1441 asqktvyssf arpdvttepf gpdnclhfnm tpncqyrpqs vpphhnkleq hqvygarsep
     1501 pasmglrynt yvapgrnasg hhskpcsrve yvsslsssvr ntcypedipp yptirrvqsl
     1561 happssmirs vpisrtevpp ddepaycprp lyqykpyqss qarsdyhvtq lqpyfengrv
     1621 hyryspysss sssyyspdga lcdvdaygtv qlrplhrlpn rdfafynprl qgkslysyag
     1681 laprpranvt gyfspndhnv vsmppaadvk htytswdled mekyrmqsir resrarqkvk
     1741 gpvmsqydnm tpavqddlgg iyvihlrsks dpgktgllsv aegkesrhaa kaispegedr
     1801 fyrrhpeaem drahhhgghg stqpekpslp qkqsslrsrk lpdmgcslpe hrahqeashr
     1861 qfceskngpp ypqgagqldy gskgipdtse pvsyhnsgvk yaasgqeslr lnhkevrlsk
     1921 emerpwvrqp sapekhsrdc ykeeehltqs ivpppkpers hslklhhtqn verdpsvlyq
     1981 yqphgkrqss vtvvsqydnl edyhslpqhq rgvfggggmg tyvppgfphp qsrtyatalg
     2041 qgaflpaels lqhpetqiha e
//
LOCUS       XP_054226598            2061 aa            linear   PRI 05-AUG-2025
DEFINITION  rho GTPase-activating protein 32 isoform X2 [Homo sapiens].
ACCESSION   XP_054226598
VERSION     XP_054226598.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370623.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2061
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2061
                     /product="rho GTPase-activating protein 32 isoform X2"
                     /calculated_mol_wt=227160
     Region          101..215
                     /region_name="PX_RICS"
                     /note="The phosphoinositide binding Phox Homology domain
                     of PX-RICS; cd07298"
                     /db_xref="CDD:132831"
     Site            order(146..148,174..175,185)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:132831"
     Region          237..290
                     /region_name="SH3_ARHGAP32_33"
                     /note="Src homology 3 domain of Rho GTPase-activating
                     proteins 32 and 33, and similar proteins; cd11835"
                     /db_xref="CDD:212769"
     Site            order(242,244,247,251,272..273,286,288..289)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212769"
     Region          342..536
                     /region_name="RhoGAP_CdGAP"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain of CdGAP-like proteins; CdGAP
                     contains an N-terminal RhoGAP domain and a C-terminal
                     proline-rich region, and it is active on both Cdc42 and
                     Rac1 but not RhoA. CdGAP is recruited to...; cd04384"
                     /db_xref="CDD:239849"
     Site            order(381,421,425,494,497..498,527)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239849"
     Site            381
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239849"
     Region          683..1055
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     CDS             1..2061
                     /gene="ARHGAP32"
                     /gene_synonym="GC-GAP; GRIT; p200RhoGAP; p250GAP; PX-RICS;
                     RICS"
                     /coded_by="XM_054370623.1:130..6315"
                     /db_xref="GeneID:9743"
                     /db_xref="HGNC:HGNC:17399"
                     /db_xref="MIM:608541"
ORIGIN      
        1 mkssvhseed dfvpelhrnv hprerpdwee tlsamargad vpeipgdltl ktcgstasmk
       61 vkhvkksttp glmgcdnihr lpftkghfpk maecahfhye nvefgsiqls lseeqnevmk
      121 ngceskelvy lvqiacqgks wivkrsyedf rvldkhlhlc iydrrfsqls elprsdtlkd
      181 spesvtqmlm aylsrlsaia gnkincgpal twmeidnkgn hllvheessi ntpavgaahv
      241 ikrytarapd eltlevgdiv svidmppkvl stwwrgkhgf qvglfpghcv elinqkvpqs
      301 vtnsvpkpvs kkhgklitfl rtfmksrptk qklkqrgilk ervfgcdlge hllnsgfevp
      361 qvlqsctafi erygivdgiy rlsgvasniq rlrhefdseh vpdltkepyv qdihsvgslc
      421 klyfrelpnp lltyqlyekf sdavsaatde erlikihdvi qqlppphyrt leflmrhlsl
      481 ladycsitnm haknlaivwa pnllrskqie sacfsgtaaf mevriqsvvv efilnhvdvl
      541 fsgrismamq egaaslsrpk sllvsspstk lltleeaqar tqaqvnspiv tenkyievge
      601 gpaalqgkfh tiiefplerk rpqnkmkksp vgswrsffnl gksssvskrk lqrnesepse
      661 mkamalkggr aegtlrsaks eesltslhav dgdsklfrpr rprsssdals asfngemlgn
      721 rcnsydnlph dneseeeggl lhipalmsph saedvdlspp digvasldfd pmsfqcsppk
      781 aeseclesga sfldspgysk dkpsankkda etgssqcqtp gstassepvs plqeklspff
      841 tldlsptedk sskpssftek vvyafspkig rklskspsms isepisvtlp prvsevigtv
      901 snttaqnass stwdkcveer datnrsptqi vkmktnetva qeayesevqp ldqvaaeeve
      961 lpgkedqsvs ssqskavasg qtqtgavthd ppqdsvpvss vslipppppp knvarmlala
     1021 laesaqqast qslkrpgtsq agytnygdia vattednlss sysavaldka yfqtdrpaeq
     1081 fhlqnnapgn cdhplpetta tgdpthsntt esgeqhhqvd ltgnqphqay lsgdpekari
     1141 tsvpldseks ddhvsfpedq sgknsmptvs fldqdqsppr fysgdqppsy lgasvdklhh
     1201 plefadkspt ppnlpsdkiy ppsgspeent statmtymtt tpataqmstk easwdvaeqp
     1261 ttadfaaatl qrthrtnrpl ppppsqrsae qppvvgqvqa atniglnnsh kvqgvvpvpe
     1321 rppepramdd pasafisdsg aaaaqcpmat avqpglpekv rdgarvpllh lraesvpahp
     1381 cgfpaplppt rmmeskmiaa ihsssadats ssnyhsfvta sstsvddalp lplpvpqpkh
     1441 asqktvyssf arpdvttepf gpdnclhfnm tpncqyrpqs vpphhnkleq hqvygarsep
     1501 pasmglrynt yvapgrnasg hhskpcsrve yvsslsssvr ntcypedipp yptirrvqsl
     1561 happssmirs vpisrtevpp ddepaycprp lyqykpyqss qarsdyhvtq lqpyfengrv
     1621 hyryspysss sssyyspdga lcdvdaygtv qlrplhrlpn rdfafynprl qgkslysyag
     1681 laprpranvt gyfspndhnv vsmppaadvk htytswdled mekyrmqsir resrarqkvk
     1741 gpvmsqydnm tpavqddlgg iyvihlrsks dpgktgllsv aegkesrhaa kaispegedr
     1801 fyrrhpeaem drahhhgghg stqpekpslp qkqsslrsrk lpdmgcslpe hrahqeashr
     1861 qfceskngpp ypqgagqldy gskgipdtse pvsyhnsgvk yaasgqeslr lnhkevrlsk
     1921 emerpwvrqp sapekhsrdc ykeeehltqs ivpppkpers hslklhhtqn verdpsvlyq
     1981 yqphgkrqss vtvvsqydnl edyhslpqhq rgvfggggmg tyvppgfphp qsrtyatalg
     2041 qgaflpaels lqhpetqiha e
//
LOCUS       XP_054226599            2069 aa            linear   PRI 05-AUG-2025
DEFINITION  rho GTPase-activating protein 32 isoform X3 [Homo sapiens].
ACCESSION   XP_054226599
VERSION     XP_054226599.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370624.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2069
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2069
                     /product="rho GTPase-activating protein 32 isoform X3"
                     /calculated_mol_wt=228235
     Region          109..223
                     /region_name="PX_RICS"
                     /note="The phosphoinositide binding Phox Homology domain
                     of PX-RICS; cd07298"
                     /db_xref="CDD:132831"
     Site            order(154..156,182..183,193)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:132831"
     Region          245..298
                     /region_name="SH3_ARHGAP32_33"
                     /note="Src homology 3 domain of Rho GTPase-activating
                     proteins 32 and 33, and similar proteins; cd11835"
                     /db_xref="CDD:212769"
     Site            order(250,252,255,259,280..281,294,296..297)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212769"
     Region          350..544
                     /region_name="RhoGAP_CdGAP"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain of CdGAP-like proteins; CdGAP
                     contains an N-terminal RhoGAP domain and a C-terminal
                     proline-rich region, and it is active on both Cdc42 and
                     Rac1 but not RhoA. CdGAP is recruited to...; cd04384"
                     /db_xref="CDD:239849"
     Site            order(389,429,433,502,505..506,535)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239849"
     Site            389
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239849"
     Region          691..1063
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     CDS             1..2069
                     /gene="ARHGAP32"
                     /gene_synonym="GC-GAP; GRIT; p200RhoGAP; p250GAP; PX-RICS;
                     RICS"
                     /coded_by="XM_054370624.1:35..6244"
                     /db_xref="GeneID:9743"
                     /db_xref="HGNC:HGNC:17399"
                     /db_xref="MIM:608541"
ORIGIN      
        1 milfqsyiem ytlesgligk kllaqwqrfs rqallhslwi ylwvmfpstv qsvvvaearg
       61 advpeipgdl tlktcgstas mkvkhvkklp ftkghfpkma ecahfhyenv efgsiqlsls
      121 eeqnevmkng ceskelvylv qiacqgkswi vkrsyedfrv ldkhlhlciy drrfsqlsel
      181 prsdtlkdsp esvtqmlmay lsrlsaiagn kincgpaltw meidnkgnhl lvheessint
      241 pavgaahvik rytarapdel tlevgdivsv idmppkvlst wwrgkhgfqv glfpghcvel
      301 inqkvpqsvt nsvpkpvskk hgklitflrt fmksrptkqk lkqrgilker vfgcdlgehl
      361 lnsgfevpqv lqsctafier ygivdgiyrl sgvasniqrl rhefdsehvp dltkepyvqd
      421 ihsvgslckl yfrelpnpll tyqlyekfsd avsaatdeer likihdviqq lppphyrtle
      481 flmrhlslla dycsitnmha knlaivwapn llrskqiesa cfsgtaafme vriqsvvvef
      541 ilnhvdvlfs grismamqeg aaslsrpksl lvsspstkll tleeaqartq aqvnspivte
      601 nkyievgegp aalqgkfhti iefplerkrp qnkmkkspvg swrsffnlgk sssvskrklq
      661 rnesepsemk amalkggrae gtlrsaksee sltslhavdg dsklfrprrp rsssdalsas
      721 fngemlgnrc nsydnlphdn eseeeggllh ipalmsphsa edvdlsppdi gvasldfdpm
      781 sfqcsppkae seclesgasf ldspgyskdk psankkdaet gssqcqtpgs tassepvspl
      841 qeklspfftl dlsptedkss kpssftekvv yafspkigrk lskspsmsis episvtlppr
      901 vsevigtvsn ttaqnassst wdkcveerda tnrsptqivk mktnetvaqe ayesevqpld
      961 qvaaeevelp gkedqsvsss qskavasgqt qtgavthdpp qdsvpvssvs lippppppkn
     1021 varmlalala esaqqastqs lkrpgtsqag ytnygdiava ttednlsssy savaldkayf
     1081 qtdrpaeqfh lqnnapgncd hplpettatg dpthsnttes geqhhqvdlt gnqphqayls
     1141 gdpekarits vpldseksdd hvsfpedqsg knsmptvsfl dqdqspprfy sgdqppsylg
     1201 asvdklhhpl efadksptpp nlpsdkiypp sgspeentst atmtymtttp ataqmstkea
     1261 swdvaeqptt adfaaatlqr thrtnrplpp ppsqrsaeqp pvvgqvqaat niglnnshkv
     1321 qgvvpvperp pepramddpa safisdsgaa aaqcpmatav qpglpekvrd garvpllhlr
     1381 aesvpahpcg fpaplpptrm meskmiaaih sssadatsss nyhsfvtass tsvddalplp
     1441 lpvpqpkhas qktvyssfar pdvttepfgp dnclhfnmtp ncqyrpqsvp phhnkleqhq
     1501 vygarseppa smglryntyv apgrnasghh skpcsrveyv sslsssvrnt cypedippyp
     1561 tirrvqslha ppssmirsvp isrtevppdd epaycprply qykpyqssqa rsdyhvtqlq
     1621 pyfengrvhy ryspysssss syyspdgalc dvdaygtvql rplhrlpnrd fafynprlqg
     1681 kslysyagla prpranvtgy fspndhnvvs mppaadvkht ytswdledme kyrmqsirre
     1741 srarqkvkgp vmsqydnmtp avqddlggiy vihlrsksdp gktgllsvae gkesrhaaka
     1801 ispegedrfy rrhpeaemdr ahhhgghgst qpekpslpqk qsslrsrklp dmgcslpehr
     1861 ahqeashrqf ceskngppyp qgagqldygs kgipdtsepv syhnsgvkya asgqeslrln
     1921 hkevrlskem erpwvrqpsa pekhsrdcyk eeehltqsiv pppkpershs lklhhtqnve
     1981 rdpsvlyqyq phgkrqssvt vvsqydnled yhslpqhqrg vfggggmgty vppgfphpqs
     2041 rtyatalgqg aflpaelslq hpetqihae
//
LOCUS       XP_054226600            2047 aa            linear   PRI 05-AUG-2025
DEFINITION  rho GTPase-activating protein 32 isoform X4 [Homo sapiens].
ACCESSION   XP_054226600
VERSION     XP_054226600.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370625.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2047
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2047
                     /product="rho GTPase-activating protein 32 isoform X4"
                     /calculated_mol_wt=225676
     Region          87..201
                     /region_name="PX_RICS"
                     /note="The phosphoinositide binding Phox Homology domain
                     of PX-RICS; cd07298"
                     /db_xref="CDD:132831"
     Site            order(132..134,160..161,171)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:132831"
     Region          223..276
                     /region_name="SH3_ARHGAP32_33"
                     /note="Src homology 3 domain of Rho GTPase-activating
                     proteins 32 and 33, and similar proteins; cd11835"
                     /db_xref="CDD:212769"
     Site            order(228,230,233,237,258..259,272,274..275)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212769"
     Region          328..522
                     /region_name="RhoGAP_CdGAP"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain of CdGAP-like proteins; CdGAP
                     contains an N-terminal RhoGAP domain and a C-terminal
                     proline-rich region, and it is active on both Cdc42 and
                     Rac1 but not RhoA. CdGAP is recruited to...; cd04384"
                     /db_xref="CDD:239849"
     Site            order(367,407,411,480,483..484,513)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239849"
     Site            367
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239849"
     Region          669..1041
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     CDS             1..2047
                     /gene="ARHGAP32"
                     /gene_synonym="GC-GAP; GRIT; p200RhoGAP; p250GAP; PX-RICS;
                     RICS"
                     /coded_by="XM_054370625.1:39..6182"
                     /db_xref="GeneID:9743"
                     /db_xref="HGNC:HGNC:17399"
                     /db_xref="MIM:608541"
ORIGIN      
        1 mkssvhseed dfvpelhrnv hprerpdwee tlsamargad vpeipgdltl ktcgstasmk
       61 vkhvkklpft kghfpkmaec ahfhyenvef gsiqlslsee qnevmkngce skelvylvqi
      121 acqgkswivk rsyedfrvld khlhlciydr rfsqlselpr sdtlkdspes vtqmlmayls
      181 rlsaiagnki ncgpaltwme idnkgnhllv heessintpa vgaahvikry tarapdeltl
      241 evgdivsvid mppkvlstww rgkhgfqvgl fpghcvelin qkvpqsvtns vpkpvskkhg
      301 klitflrtfm ksrptkqklk qrgilkervf gcdlgehlln sgfevpqvlq sctafieryg
      361 ivdgiyrlsg vasniqrlrh efdsehvpdl tkepyvqdih svgslcklyf relpnpllty
      421 qlyekfsdav saatdeerli kihdviqqlp pphyrtlefl mrhlsllady csitnmhakn
      481 laivwapnll rskqiesacf sgtaafmevr iqsvvvefil nhvdvlfsgr ismamqegaa
      541 slsrpksllv sspstklltl eeaqartqaq vnspivtenk yievgegpaa lqgkfhtiie
      601 fplerkrpqn kmkkspvgsw rsffnlgkss svskrklqrn esepsemkam alkggraegt
      661 lrsakseesl tslhavdgds klfrprrprs ssdalsasfn gemlgnrcns ydnlphdnes
      721 eeeggllhip almsphsaed vdlsppdigv asldfdpmsf qcsppkaese clesgasfld
      781 spgyskdkps ankkdaetgs sqcqtpgsta ssepvsplqe klspfftldl sptedksskp
      841 ssftekvvya fspkigrkls kspsmsisep isvtlpprvs evigtvsntt aqnassstwd
      901 kcveerdatn rsptqivkmk tnetvaqeay esevqpldqv aaeevelpgk edqsvsssqs
      961 kavasgqtqt gavthdppqd svpvssvsli ppppppknva rmlalalaes aqqastqslk
     1021 rpgtsqagyt nygdiavatt ednlsssysa valdkayfqt drpaeqfhlq nnapgncdhp
     1081 lpettatgdp thsnttesge qhhqvdltgn qphqaylsgd pekaritsvp ldseksddhv
     1141 sfpedqsgkn smptvsfldq dqspprfysg dqppsylgas vdklhhplef adksptppnl
     1201 psdkiyppsg speentstat mtymtttpat aqmstkeasw dvaeqpttad faaatlqrth
     1261 rtnrplpppp sqrsaeqppv vgqvqaatni glnnshkvqg vvpvperppe pramddpasa
     1321 fisdsgaaaa qcpmatavqp glpekvrdga rvpllhlrae svpahpcgfp aplpptrmme
     1381 skmiaaihss sadatsssny hsfvtassts vddalplplp vpqpkhasqk tvyssfarpd
     1441 vttepfgpdn clhfnmtpnc qyrpqsvpph hnkleqhqvy garseppasm glryntyvap
     1501 grnasghhsk pcsrveyvss lsssvrntcy pedippypti rrvqslhapp ssmirsvpis
     1561 rtevppddep aycprplyqy kpyqssqars dyhvtqlqpy fengrvhyry spyssssssy
     1621 yspdgalcdv daygtvqlrp lhrlpnrdfa fynprlqgks lysyaglapr pranvtgyfs
     1681 pndhnvvsmp paadvkhtyt swdledmeky rmqsirresr arqkvkgpvm sqydnmtpav
     1741 qddlggiyvi hlrsksdpgk tgllsvaegk esrhaakais pegedrfyrr hpeaemdrah
     1801 hhgghgstqp ekpslpqkqs slrsrklpdm gcslpehrah qeashrqfce skngppypqg
     1861 agqldygskg ipdtsepvsy hnsgvkyaas gqeslrlnhk evrlskemer pwvrqpsape
     1921 khsrdcykee ehltqsivpp pkpershslk lhhtqnverd psvlyqyqph gkrqssvtvv
     1981 sqydnledyh slpqhqrgvf ggggmgtyvp pgfphpqsrt yatalgqgaf lpaelslqhp
     2041 etqihae
//
LOCUS       XP_054226601            2047 aa            linear   PRI 05-AUG-2025
DEFINITION  rho GTPase-activating protein 32 isoform X4 [Homo sapiens].
ACCESSION   XP_054226601
VERSION     XP_054226601.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370626.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..2047
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..2047
                     /product="rho GTPase-activating protein 32 isoform X4"
                     /calculated_mol_wt=225676
     Region          87..201
                     /region_name="PX_RICS"
                     /note="The phosphoinositide binding Phox Homology domain
                     of PX-RICS; cd07298"
                     /db_xref="CDD:132831"
     Site            order(132..134,160..161,171)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:132831"
     Region          223..276
                     /region_name="SH3_ARHGAP32_33"
                     /note="Src homology 3 domain of Rho GTPase-activating
                     proteins 32 and 33, and similar proteins; cd11835"
                     /db_xref="CDD:212769"
     Site            order(228,230,233,237,258..259,272,274..275)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212769"
     Region          328..522
                     /region_name="RhoGAP_CdGAP"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain of CdGAP-like proteins; CdGAP
                     contains an N-terminal RhoGAP domain and a C-terminal
                     proline-rich region, and it is active on both Cdc42 and
                     Rac1 but not RhoA. CdGAP is recruited to...; cd04384"
                     /db_xref="CDD:239849"
     Site            order(367,407,411,480,483..484,513)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239849"
     Site            367
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239849"
     Region          669..1041
                     /region_name="DUF5585"
                     /note="Family of unknown function (DUF5585); pfam17823"
                     /db_xref="CDD:465521"
     CDS             1..2047
                     /gene="ARHGAP32"
                     /gene_synonym="GC-GAP; GRIT; p200RhoGAP; p250GAP; PX-RICS;
                     RICS"
                     /coded_by="XM_054370626.1:71..6214"
                     /db_xref="GeneID:9743"
                     /db_xref="HGNC:HGNC:17399"
                     /db_xref="MIM:608541"
ORIGIN      
        1 mkssvhseed dfvpelhrnv hprerpdwee tlsamargad vpeipgdltl ktcgstasmk
       61 vkhvkklpft kghfpkmaec ahfhyenvef gsiqlslsee qnevmkngce skelvylvqi
      121 acqgkswivk rsyedfrvld khlhlciydr rfsqlselpr sdtlkdspes vtqmlmayls
      181 rlsaiagnki ncgpaltwme idnkgnhllv heessintpa vgaahvikry tarapdeltl
      241 evgdivsvid mppkvlstww rgkhgfqvgl fpghcvelin qkvpqsvtns vpkpvskkhg
      301 klitflrtfm ksrptkqklk qrgilkervf gcdlgehlln sgfevpqvlq sctafieryg
      361 ivdgiyrlsg vasniqrlrh efdsehvpdl tkepyvqdih svgslcklyf relpnpllty
      421 qlyekfsdav saatdeerli kihdviqqlp pphyrtlefl mrhlsllady csitnmhakn
      481 laivwapnll rskqiesacf sgtaafmevr iqsvvvefil nhvdvlfsgr ismamqegaa
      541 slsrpksllv sspstklltl eeaqartqaq vnspivtenk yievgegpaa lqgkfhtiie
      601 fplerkrpqn kmkkspvgsw rsffnlgkss svskrklqrn esepsemkam alkggraegt
      661 lrsakseesl tslhavdgds klfrprrprs ssdalsasfn gemlgnrcns ydnlphdnes
      721 eeeggllhip almsphsaed vdlsppdigv asldfdpmsf qcsppkaese clesgasfld
      781 spgyskdkps ankkdaetgs sqcqtpgsta ssepvsplqe klspfftldl sptedksskp
      841 ssftekvvya fspkigrkls kspsmsisep isvtlpprvs evigtvsntt aqnassstwd
      901 kcveerdatn rsptqivkmk tnetvaqeay esevqpldqv aaeevelpgk edqsvsssqs
      961 kavasgqtqt gavthdppqd svpvssvsli ppppppknva rmlalalaes aqqastqslk
     1021 rpgtsqagyt nygdiavatt ednlsssysa valdkayfqt drpaeqfhlq nnapgncdhp
     1081 lpettatgdp thsnttesge qhhqvdltgn qphqaylsgd pekaritsvp ldseksddhv
     1141 sfpedqsgkn smptvsfldq dqspprfysg dqppsylgas vdklhhplef adksptppnl
     1201 psdkiyppsg speentstat mtymtttpat aqmstkeasw dvaeqpttad faaatlqrth
     1261 rtnrplpppp sqrsaeqppv vgqvqaatni glnnshkvqg vvpvperppe pramddpasa
     1321 fisdsgaaaa qcpmatavqp glpekvrdga rvpllhlrae svpahpcgfp aplpptrmme
     1381 skmiaaihss sadatsssny hsfvtassts vddalplplp vpqpkhasqk tvyssfarpd
     1441 vttepfgpdn clhfnmtpnc qyrpqsvpph hnkleqhqvy garseppasm glryntyvap
     1501 grnasghhsk pcsrveyvss lsssvrntcy pedippypti rrvqslhapp ssmirsvpis
     1561 rtevppddep aycprplyqy kpyqssqars dyhvtqlqpy fengrvhyry spyssssssy
     1621 yspdgalcdv daygtvqlrp lhrlpnrdfa fynprlqgks lysyaglapr pranvtgyfs
     1681 pndhnvvsmp paadvkhtyt swdledmeky rmqsirresr arqkvkgpvm sqydnmtpav
     1741 qddlggiyvi hlrsksdpgk tgllsvaegk esrhaakais pegedrfyrr hpeaemdrah
     1801 hhgghgstqp ekpslpqkqs slrsrklpdm gcslpehrah qeashrqfce skngppypqg
     1861 agqldygskg ipdtsepvsy hnsgvkyaas gqeslrlnhk evrlskemer pwvrqpsape
     1921 khsrdcykee ehltqsivpp pkpershslk lhhtqnverd psvlyqyqph gkrqssvtvv
     1981 sqydnledyh slpqhqrgvf ggggmgtyvp pgfphpqsrt yatalgqgaf lpaelslqhp
     2041 etqihae
//
LOCUS       XP_054226602            1762 aa            linear   PRI 05-AUG-2025
DEFINITION  rho GTPase-activating protein 32 isoform X5 [Homo sapiens].
ACCESSION   XP_054226602
VERSION     XP_054226602.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370627.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1762
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1762
                     /product="rho GTPase-activating protein 32 isoform X5"
                     /calculated_mol_wt=193678
     Region          43..237
                     /region_name="RhoGAP_CdGAP"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain of CdGAP-like proteins; CdGAP
                     contains an N-terminal RhoGAP domain and a C-terminal
                     proline-rich region, and it is active on both Cdc42 and
                     Rac1 but not RhoA. CdGAP is recruited to...; cd04384"
                     /db_xref="CDD:239849"
     Site            order(82,122,126,195,198..199,228)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239849"
     Site            82
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239849"
     CDS             1..1762
                     /gene="ARHGAP32"
                     /gene_synonym="GC-GAP; GRIT; p200RhoGAP; p250GAP; PX-RICS;
                     RICS"
                     /coded_by="XM_054370627.1:89..5377"
                     /db_xref="GeneID:9743"
                     /db_xref="HGNC:HGNC:17399"
                     /db_xref="MIM:608541"
ORIGIN      
        1 mverqaripv skkhgklitf lrtfmksrpt kqklkqrgil kervfgcdlg ehllnsgfev
       61 pqvlqsctaf ierygivdgi yrlsgvasni qrlrhefdse hvpdltkepy vqdihsvgsl
      121 cklyfrelpn plltyqlyek fsdavsaatd eerlikihdv iqqlppphyr tleflmrhls
      181 lladycsitn mhaknlaivw apnllrskqi esacfsgtaa fmevriqsvv vefilnhvdv
      241 lfsgrismam qegaaslsrp ksllvsspst klltleeaqa rtqaqvnspi vtenkyievg
      301 egpaalqgkf htiiefpler krpqnkmkks pvgswrsffn lgksssvskr klqrneseps
      361 emkamalkgg raegtlrsak seesltslha vdgdsklfrp rrprsssdal sasfngemlg
      421 nrcnsydnlp hdneseeegg llhipalmsp hsaedvdlsp pdigvasldf dpmsfqcspp
      481 kaeseclesg asfldspgys kdkpsankkd aetgssqcqt pgstassepv splqeklspf
      541 ftldlspted ksskpssfte kvvyafspki grklskspsm sisepisvtl pprvsevigt
      601 vsnttaqnas sstwdkcvee rdatnrsptq ivkmktnetv aqeayesevq pldqvaaeev
      661 elpgkedqsv sssqskavas gqtqtgavth dppqdsvpvs svslippppp pknvarmlal
      721 alaesaqqas tqslkrpgts qagytnygdi avattednls ssysavaldk ayfqtdrpae
      781 qfhlqnnapg ncdhplpett atgdpthsnt tesgeqhhqv dltgnqphqa ylsgdpekar
      841 itsvpldsek sddhvsfped qsgknsmptv sfldqdqspp rfysgdqpps ylgasvdklh
      901 hplefadksp tppnlpsdki yppsgspeen tstatmtymt ttpataqmst keaswdvaeq
      961 pttadfaaat lqrthrtnrp lppppsqrsa eqppvvgqvq aatniglnns hkvqgvvpvp
     1021 erppepramd dpasafisds gaaaaqcpma tavqpglpek vrdgarvpll hlraesvpah
     1081 pcgfpaplpp trmmeskmia aihsssadat sssnyhsfvt asstsvddal plplpvpqpk
     1141 hasqktvyss farpdvttep fgpdnclhfn mtpncqyrpq svpphhnkle qhqvygarse
     1201 ppasmglryn tyvapgrnas ghhskpcsrv eyvsslsssv rntcypedip pyptirrvqs
     1261 lhappssmir svpisrtevp pddepaycpr plyqykpyqs sqarsdyhvt qlqpyfengr
     1321 vhyryspyss ssssyyspdg alcdvdaygt vqlrplhrlp nrdfafynpr lqgkslysya
     1381 glaprpranv tgyfspndhn vvsmppaadv khtytswdle dmekyrmqsi rresrarqkv
     1441 kgpvmsqydn mtpavqddlg giyvihlrsk sdpgktglls vaegkesrha akaispeged
     1501 rfyrrhpeae mdrahhhggh gstqpekpsl pqkqsslrsr klpdmgcslp ehrahqeash
     1561 rqfceskngp pypqgagqld ygskgipdts epvsyhnsgv kyaasgqesl rlnhkevrls
     1621 kemerpwvrq psapekhsrd cykeeehltq sivpppkper shslklhhtq nverdpsvly
     1681 qyqphgkrqs svtvvsqydn ledyhslpqh qrgvfggggm gtyvppgfph pqsrtyatal
     1741 gqgaflpael slqhpetqih ae
//
LOCUS       XP_054226603             660 aa            linear   PRI 05-AUG-2025
DEFINITION  rho GTPase-activating protein 32 isoform X6 [Homo sapiens].
ACCESSION   XP_054226603
VERSION     XP_054226603.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370628.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..660
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..660
                     /product="rho GTPase-activating protein 32 isoform X6"
                     /calculated_mol_wt=74422
     Region          141..255
                     /region_name="PX_RICS"
                     /note="The phosphoinositide binding Phox Homology domain
                     of PX-RICS; cd07298"
                     /db_xref="CDD:132831"
     Site            order(186..188,214..215,225)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:132831"
     Region          277..330
                     /region_name="SH3_ARHGAP32_33"
                     /note="Src homology 3 domain of Rho GTPase-activating
                     proteins 32 and 33, and similar proteins; cd11835"
                     /db_xref="CDD:212769"
     Site            order(282,284,287,291,312..313,326,328..329)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212769"
     Region          382..576
                     /region_name="RhoGAP_CdGAP"
                     /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like
                     small GTPases) domain of CdGAP-like proteins; CdGAP
                     contains an N-terminal RhoGAP domain and a C-terminal
                     proline-rich region, and it is active on both Cdc42 and
                     Rac1 but not RhoA. CdGAP is recruited to...; cd04384"
                     /db_xref="CDD:239849"
     Site            order(421,461,465,534,537..538,567)
                     /site_type="other"
                     /note="putative GTPase interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239849"
     Site            421
                     /site_type="active"
                     /note="catalytic residue [active]"
                     /db_xref="CDD:239849"
     CDS             1..660
                     /gene="ARHGAP32"
                     /gene_synonym="GC-GAP; GRIT; p200RhoGAP; p250GAP; PX-RICS;
                     RICS"
                     /coded_by="XM_054370628.1:128..2110"
                     /db_xref="GeneID:9743"
                     /db_xref="HGNC:HGNC:17399"
                     /db_xref="MIM:608541"
ORIGIN      
        1 metesesstl gddsvfwles eviiqvtdce eeereekfrk mkssvhseed dfvpelhrnv
       61 hprerpdwee tlsamargad vpeipgdltl ktcgstasmk vkhvkksttp glmgcdnihr
      121 lpftkghfpk maecahfhye nvefgsiqls lseeqnevmk ngceskelvy lvqiacqgks
      181 wivkrsyedf rvldkhlhlc iydrrfsqls elprsdtlkd spesvtqmlm aylsrlsaia
      241 gnkincgpal twmeidnkgn hllvheessi ntpavgaahv ikrytarapd eltlevgdiv
      301 svidmppkvl stwwrgkhgf qvglfpghcv elinqkvpqs vtnsvpkpvs kkhgklitfl
      361 rtfmksrptk qklkqrgilk ervfgcdlge hllnsgfevp qvlqsctafi erygivdgiy
      421 rlsgvasniq rlrhefdseh vpdltkepyv qdihsvgslc klyfrelpnp lltyqlyekf
      481 sdavsaatde erlikihdvi qqlppphyrt leflmrhlsl ladycsitnm haknlaivwa
      541 pnllrskqie sacfsgtaaf mevriqsvvv efilnhvdvl fsgrismamq egaaslsrpk
      601 sllvsspstk lltleeaqar tqaqvnspiv tenkyievge gpaalqgkfh tiiefplerl
//
LOCUS       XP_054226604             335 aa            linear   PRI 05-AUG-2025
DEFINITION  CD81 antigen isoform X4 [Homo sapiens].
ACCESSION   XP_054226604
VERSION     XP_054226604.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370629.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..335
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..335
                     /product="CD81 antigen isoform X4"
                     /calculated_mol_wt=35758
     Region          122..327
                     /region_name="Tetraspanin"
                     /note="Tetraspanin family; pfam00335"
                     /db_xref="CDD:459767"
     CDS             1..335
                     /gene="CD81"
                     /gene_synonym="CVID6; S5.7; TAPA1; TSPAN28"
                     /coded_by="XM_054370629.1:44..1051"
                     /db_xref="GeneID:975"
                     /db_xref="HGNC:HGNC:1701"
                     /db_xref="MIM:186845"
ORIGIN      
        1 mitqrrtrav acpssmhpcc gvpvvcvacl svhpccgvpv vcvaclsvhp crgvpvvcap
       61 vlwcalrlfl llpgrvaptc asqrrtpgsp vhrsssrsll kvgelgmapf vharagktka
      121 qlaggvilgv alwlrhdpqt tnllylelgd kpapntfyvg iyiliavgav mmfvgflgcy
      181 gaiqesqcll gtfftclvil facevaagiw gfvnkdqiak dvkqfydqal qqavvdddan
      241 nakavvktfh etldccgsst ltalttsvlk nnlcpsgsni isnlfkedch qkiddlfsgk
      301 lyligiaaiv vavimifemi lsmvlccgir nssvy
//
LOCUS       XP_054226605             303 aa            linear   PRI 05-AUG-2025
DEFINITION  CD81 antigen isoform X1 [Homo sapiens].
ACCESSION   XP_054226605
VERSION     XP_054226605.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370630.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..303
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..303
                     /product="CD81 antigen isoform X1"
                     /calculated_mol_wt=32766
     Region          90..295
                     /region_name="Tetraspanin"
                     /note="Tetraspanin family; pfam00335"
                     /db_xref="CDD:459767"
     CDS             1..303
                     /gene="CD81"
                     /gene_synonym="CVID6; S5.7; TAPA1; TSPAN28"
                     /coded_by="XM_054370630.1:5..916"
                     /db_xref="GeneID:975"
                     /db_xref="HGNC:HGNC:1701"
                     /db_xref="MIM:186845"
ORIGIN      
        1 msgavtshlp qaglfctacl grwweslwps alpwqwgqlg hlggarlpqa rpwdlsgclv
       61 vacfspgmwe rhqtqdvplp apeapspdel aggvilgval wlrhdpqttn llylelgdkp
      121 apntfyvgiy iliavgavmm fvgflgcyga iqesqcllgt fftclvilfa cevaagiwgf
      181 vnkdqiakdv kqfydqalqq avvdddanna kavvktfhet ldccgsstlt alttsvlknn
      241 lcpsgsniis nlfkedchqk iddlfsgkly ligiaaivva vimifemils mvlccgirns
      301 svy
//
LOCUS       XP_054226606             274 aa            linear   PRI 05-AUG-2025
DEFINITION  CD81 antigen isoform X5 [Homo sapiens].
ACCESSION   XP_054226606
VERSION     XP_054226606.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370631.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..274
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..274
                     /product="CD81 antigen isoform X5"
                     /calculated_mol_wt=29675
     Region          61..266
                     /region_name="Tetraspanin"
                     /note="Tetraspanin family; pfam00335"
                     /db_xref="CDD:459767"
     Region          151..240
                     /region_name="CD81_like_LEL"
                     /note="Tetraspanin, extracellular domain or large
                     extracellular loop (LEL), CD81_like subfamily.
                     Tetraspanins are trans-membrane proteins with 4
                     trans-membrane segments. Both the N- and C-termini lie on
                     the intracellular side of the membrane. This alignment...;
                     cd03151"
                     /db_xref="CDD:239404"
     Site            order(152,157,161,163..164,167,184,187..188,191..192)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:239404"
     CDS             1..274
                     /gene="CD81"
                     /gene_synonym="CVID6; S5.7; TAPA1; TSPAN28"
                     /coded_by="XM_054370631.1:15..839"
                     /db_xref="GeneID:975"
                     /db_xref="HGNC:HGNC:1701"
                     /db_xref="MIM:186845"
ORIGIN      
        1 mwcgwsfswq pvhwvrsacg csltwvswsl assssrsllk vgelgmapfv haragktkaq
       61 laggvilgva lwlrhdpqtt nllylelgdk papntfyvgi yiliavgavm mfvgflgcyg
      121 aiqesqcllg tfftclvilf acevaagiwg fvnkdqiakd vkqfydqalq qavvdddann
      181 akavvktfhe tldccgsstl talttsvlkn nlcpsgsnii snlfkedchq kiddlfsgkl
      241 yligiaaivv avimifemil smvlccgirn ssvy
//
LOCUS       XP_054226607             229 aa            linear   PRI 05-AUG-2025
DEFINITION  CD81 antigen isoform X2 [Homo sapiens].
ACCESSION   XP_054226607
VERSION     XP_054226607.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370632.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..229
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..229
                     /product="CD81 antigen isoform X2"
                     /calculated_mol_wt=24646
     Region          16..221
                     /region_name="Tetraspanin"
                     /note="Tetraspanin family; pfam00335"
                     /db_xref="CDD:459767"
     Region          106..195
                     /region_name="CD81_like_LEL"
                     /note="Tetraspanin, extracellular domain or large
                     extracellular loop (LEL), CD81_like subfamily.
                     Tetraspanins are trans-membrane proteins with 4
                     trans-membrane segments. Both the N- and C-termini lie on
                     the intracellular side of the membrane. This alignment...;
                     cd03151"
                     /db_xref="CDD:239404"
     Site            order(107,112,116,118..119,122,139,142..143,146..147)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:239404"
     CDS             1..229
                     /gene="CD81"
                     /gene_synonym="CVID6; S5.7; TAPA1; TSPAN28"
                     /coded_by="XM_054370632.1:103..792"
                     /db_xref="GeneID:975"
                     /db_xref="HGNC:HGNC:1701"
                     /db_xref="MIM:186845"
ORIGIN      
        1 mapfvharag ktkaqlaggv ilgvalwlrh dpqttnllyl elgdkpapnt fyvgiyilia
       61 vgavmmfvgf lgcygaiqes qcllgtfftc lvilfaceva agiwgfvnkd qiakdvkqfy
      121 dqalqqavvd ddannakavv ktfhetldcc gsstltaltt svlknnlcps gsniisnlfk
      181 edchqkiddl fsgklyligi aaivvavimi femilsmvlc cgirnssvy
//
LOCUS       XP_054226609             253 aa            linear   PRI 05-AUG-2025
DEFINITION  CD151 antigen isoform X1 [Homo sapiens].
ACCESSION   XP_054226609
VERSION     XP_054226609.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370634.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..253
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..253
                     /product="CD151 antigen isoform X1"
                     /calculated_mol_wt=28164
     Region          16..246
                     /region_name="Tetraspanin"
                     /note="Tetraspanin family; pfam00335"
                     /db_xref="CDD:459767"
     Region          112..220
                     /region_name="CD151_like_LEL"
                     /note="Tetraspanin, extracellular domain or large
                     extracellular loop (LEL), CD151_Like family. Tetraspanins
                     are trans-membrane proteins with 4 trans-membrane
                     segments. Both the N- and C-termini lie on the
                     intracellular side of the membrane. This alignment
                     model...; cd03155"
                     /db_xref="CDD:239408"
     Site            order(113,118,122,124..125,128,145,148..149,152..153)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:239408"
     CDS             1..253
                     /gene="CD151"
                     /gene_synonym="EBS7; GP27; MER2; PETA-3; RAPH; SFA1;
                     TSPAN24"
                     /coded_by="XM_054370634.1:145..906"
                     /db_xref="GeneID:977"
                     /db_xref="HGNC:HGNC:1630"
                     /db_xref="MIM:602243"
ORIGIN      
        1 mgefnekktt cgtvclkyll ftynccfwla glavmavgiw tlalksdyis llasgtylat
       61 ayilvvagtv vmvtgvlgcc atfkerrnll rlyfilllii flleiiagil ayayyqqlnt
      121 elkenlkdtm tkryhqpghe avtsavdqlq qefhccgsnn sqdwrdsewi rsqeaggrvv
      181 pdsccktvva lcgqrdhasn iykveggcit kletfiqehl rvigavgigi acvqvfgmif
      241 tcclyrslkl ehy
//
LOCUS       XP_054226610             658 aa            linear   PRI 05-AUG-2025
DEFINITION  GRB2-associated-binding protein 2 isoform X1 [Homo sapiens].
ACCESSION   XP_054226610
VERSION     XP_054226610.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370635.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..658
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..658
                     /product="GRB2-associated-binding protein 2 isoform X1"
                     /calculated_mol_wt=72269
     Region          8..108
                     /region_name="PH-like"
                     /note="Pleckstrin homology-like domain; cl17171"
                     /db_xref="CDD:473070"
     CDS             1..658
                     /gene="GAB2"
                     /coded_by="XM_054370635.1:831..2807"
                     /db_xref="GeneID:9846"
                     /db_xref="HGNC:HGNC:14458"
                     /db_xref="MIM:606203"
ORIGIN      
        1 masaqekawk krwfilrsgr msgdpdvley ykndhskkpl riinlnfceq vdagltfnkk
       61 elqdsfvfdi ktsertfylv aeteedmnkw vqsicqicgf nqaeestdsl rnvssaghgp
      121 rsspaelsss sqhllrerks sapshssqpt lftfeppvsn hmqptlstsa pqeylylhqc
      181 isrraenars asfsqgtras flmrsdtavq klaqgnghcv ngisgqvhgf yslpkpsrhn
      241 tefrdstydl prslashght kgsltgsetd nedvytfktp sntlcrefgd llvdnmdvpa
      301 tplsayqipr tftldknhna mtvatpgdsa iappprppkp sqaetprwgs pqqrppisen
      361 srsvaatipr rntlpamdns rlhrasscet yeypqrgges agrsaesmsd gvgsflpgkm
      421 ivgrsdstns ednyvpmnpg sstllamera gdnsqsvyip mspgahhfds lgypsttlpv
      481 hrgpsrgsei qpppvnrnlk pdrkakptpl dlrnntvide lpfkspitks wsranhtfns
      541 sssqycrpis tqsitstdsg dseenyvpmq npvsaspvps gtnspapkks tgsvdylald
      601 fqpsspsphr kpstssvtsd ekvdyvqvdk ektqalqntm qewtdvrqss epskgakl
//
LOCUS       XP_054226611             638 aa            linear   PRI 05-AUG-2025
DEFINITION  GRB2-associated-binding protein 2 isoform X2 [Homo sapiens].
ACCESSION   XP_054226611
VERSION     XP_054226611.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370636.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..638
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..638
                     /product="GRB2-associated-binding protein 2 isoform X2"
                     /calculated_mol_wt=69837
     Region          <1..88
                     /region_name="PH-like"
                     /note="Pleckstrin homology-like domain; cl17171"
                     /db_xref="CDD:473070"
     CDS             1..638
                     /gene="GAB2"
                     /coded_by="XM_054370636.1:59..1975"
                     /db_xref="GeneID:9846"
                     /db_xref="HGNC:HGNC:14458"
                     /db_xref="MIM:606203"
ORIGIN      
        1 msgdpdvley ykndhskkpl riinlnfceq vdagltfnkk elqdsfvfdi ktsertfylv
       61 aeteedmnkw vqsicqicgf nqaeestdsl rnvssaghgp rsspaelsss sqhllrerks
      121 sapshssqpt lftfeppvsn hmqptlstsa pqeylylhqc isrraenars asfsqgtras
      181 flmrsdtavq klaqgnghcv ngisgqvhgf yslpkpsrhn tefrdstydl prslashght
      241 kgsltgsetd nedvytfktp sntlcrefgd llvdnmdvpa tplsayqipr tftldknhna
      301 mtvatpgdsa iappprppkp sqaetprwgs pqqrppisen srsvaatipr rntlpamdns
      361 rlhrasscet yeypqrgges agrsaesmsd gvgsflpgkm ivgrsdstns ednyvpmnpg
      421 sstllamera gdnsqsvyip mspgahhfds lgypsttlpv hrgpsrgsei qpppvnrnlk
      481 pdrkakptpl dlrnntvide lpfkspitks wsranhtfns sssqycrpis tqsitstdsg
      541 dseenyvpmq npvsaspvps gtnspapkks tgsvdylald fqpsspsphr kpstssvtsd
      601 ekvdyvqvdk ektqalqntm qewtdvrqss epskgakl
//
LOCUS       XP_054226612             638 aa            linear   PRI 05-AUG-2025
DEFINITION  GRB2-associated-binding protein 2 isoform X2 [Homo sapiens].
ACCESSION   XP_054226612
VERSION     XP_054226612.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370637.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..638
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..638
                     /product="GRB2-associated-binding protein 2 isoform X2"
                     /calculated_mol_wt=69837
     Region          <1..88
                     /region_name="PH-like"
                     /note="Pleckstrin homology-like domain; cl17171"
                     /db_xref="CDD:473070"
     CDS             1..638
                     /gene="GAB2"
                     /coded_by="XM_054370637.1:59..1975"
                     /db_xref="GeneID:9846"
                     /db_xref="HGNC:HGNC:14458"
                     /db_xref="MIM:606203"
ORIGIN      
        1 msgdpdvley ykndhskkpl riinlnfceq vdagltfnkk elqdsfvfdi ktsertfylv
       61 aeteedmnkw vqsicqicgf nqaeestdsl rnvssaghgp rsspaelsss sqhllrerks
      121 sapshssqpt lftfeppvsn hmqptlstsa pqeylylhqc isrraenars asfsqgtras
      181 flmrsdtavq klaqgnghcv ngisgqvhgf yslpkpsrhn tefrdstydl prslashght
      241 kgsltgsetd nedvytfktp sntlcrefgd llvdnmdvpa tplsayqipr tftldknhna
      301 mtvatpgdsa iappprppkp sqaetprwgs pqqrppisen srsvaatipr rntlpamdns
      361 rlhrasscet yeypqrgges agrsaesmsd gvgsflpgkm ivgrsdstns ednyvpmnpg
      421 sstllamera gdnsqsvyip mspgahhfds lgypsttlpv hrgpsrgsei qpppvnrnlk
      481 pdrkakptpl dlrnntvide lpfkspitks wsranhtfns sssqycrpis tqsitstdsg
      541 dseenyvpmq npvsaspvps gtnspapkks tgsvdylald fqpsspsphr kpstssvtsd
      601 ekvdyvqvdk ektqalqntm qewtdvrqss epskgakl
//
LOCUS       XP_054226613             638 aa            linear   PRI 05-AUG-2025
DEFINITION  GRB2-associated-binding protein 2 isoform X2 [Homo sapiens].
ACCESSION   XP_054226613
VERSION     XP_054226613.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370638.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..638
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..638
                     /product="GRB2-associated-binding protein 2 isoform X2"
                     /calculated_mol_wt=69837
     Region          <1..88
                     /region_name="PH-like"
                     /note="Pleckstrin homology-like domain; cl17171"
                     /db_xref="CDD:473070"
     CDS             1..638
                     /gene="GAB2"
                     /coded_by="XM_054370638.1:209..2125"
                     /db_xref="GeneID:9846"
                     /db_xref="HGNC:HGNC:14458"
                     /db_xref="MIM:606203"
ORIGIN      
        1 msgdpdvley ykndhskkpl riinlnfceq vdagltfnkk elqdsfvfdi ktsertfylv
       61 aeteedmnkw vqsicqicgf nqaeestdsl rnvssaghgp rsspaelsss sqhllrerks
      121 sapshssqpt lftfeppvsn hmqptlstsa pqeylylhqc isrraenars asfsqgtras
      181 flmrsdtavq klaqgnghcv ngisgqvhgf yslpkpsrhn tefrdstydl prslashght
      241 kgsltgsetd nedvytfktp sntlcrefgd llvdnmdvpa tplsayqipr tftldknhna
      301 mtvatpgdsa iappprppkp sqaetprwgs pqqrppisen srsvaatipr rntlpamdns
      361 rlhrasscet yeypqrgges agrsaesmsd gvgsflpgkm ivgrsdstns ednyvpmnpg
      421 sstllamera gdnsqsvyip mspgahhfds lgypsttlpv hrgpsrgsei qpppvnrnlk
      481 pdrkakptpl dlrnntvide lpfkspitks wsranhtfns sssqycrpis tqsitstdsg
      541 dseenyvpmq npvsaspvps gtnspapkks tgsvdylald fqpsspsphr kpstssvtsd
      601 ekvdyvqvdk ektqalqntm qewtdvrqss epskgakl
//
LOCUS       XP_054226614             638 aa            linear   PRI 05-AUG-2025
DEFINITION  GRB2-associated-binding protein 2 isoform X2 [Homo sapiens].
ACCESSION   XP_054226614
VERSION     XP_054226614.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370639.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..638
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..638
                     /product="GRB2-associated-binding protein 2 isoform X2"
                     /calculated_mol_wt=69837
     Region          <1..88
                     /region_name="PH-like"
                     /note="Pleckstrin homology-like domain; cl17171"
                     /db_xref="CDD:473070"
     CDS             1..638
                     /gene="GAB2"
                     /coded_by="XM_054370639.1:63..1979"
                     /db_xref="GeneID:9846"
                     /db_xref="HGNC:HGNC:14458"
                     /db_xref="MIM:606203"
ORIGIN      
        1 msgdpdvley ykndhskkpl riinlnfceq vdagltfnkk elqdsfvfdi ktsertfylv
       61 aeteedmnkw vqsicqicgf nqaeestdsl rnvssaghgp rsspaelsss sqhllrerks
      121 sapshssqpt lftfeppvsn hmqptlstsa pqeylylhqc isrraenars asfsqgtras
      181 flmrsdtavq klaqgnghcv ngisgqvhgf yslpkpsrhn tefrdstydl prslashght
      241 kgsltgsetd nedvytfktp sntlcrefgd llvdnmdvpa tplsayqipr tftldknhna
      301 mtvatpgdsa iappprppkp sqaetprwgs pqqrppisen srsvaatipr rntlpamdns
      361 rlhrasscet yeypqrgges agrsaesmsd gvgsflpgkm ivgrsdstns ednyvpmnpg
      421 sstllamera gdnsqsvyip mspgahhfds lgypsttlpv hrgpsrgsei qpppvnrnlk
      481 pdrkakptpl dlrnntvide lpfkspitks wsranhtfns sssqycrpis tqsitstdsg
      541 dseenyvpmq npvsaspvps gtnspapkks tgsvdylald fqpsspsphr kpstssvtsd
      601 ekvdyvqvdk ektqalqntm qewtdvrqss epskgakl
//
LOCUS       XP_054226615             638 aa            linear   PRI 05-AUG-2025
DEFINITION  GRB2-associated-binding protein 2 isoform X2 [Homo sapiens].
ACCESSION   XP_054226615
VERSION     XP_054226615.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370640.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..638
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..638
                     /product="GRB2-associated-binding protein 2 isoform X2"
                     /calculated_mol_wt=69837
     Region          <1..88
                     /region_name="PH-like"
                     /note="Pleckstrin homology-like domain; cl17171"
                     /db_xref="CDD:473070"
     CDS             1..638
                     /gene="GAB2"
                     /coded_by="XM_054370640.1:59..1975"
                     /db_xref="GeneID:9846"
                     /db_xref="HGNC:HGNC:14458"
                     /db_xref="MIM:606203"
ORIGIN      
        1 msgdpdvley ykndhskkpl riinlnfceq vdagltfnkk elqdsfvfdi ktsertfylv
       61 aeteedmnkw vqsicqicgf nqaeestdsl rnvssaghgp rsspaelsss sqhllrerks
      121 sapshssqpt lftfeppvsn hmqptlstsa pqeylylhqc isrraenars asfsqgtras
      181 flmrsdtavq klaqgnghcv ngisgqvhgf yslpkpsrhn tefrdstydl prslashght
      241 kgsltgsetd nedvytfktp sntlcrefgd llvdnmdvpa tplsayqipr tftldknhna
      301 mtvatpgdsa iappprppkp sqaetprwgs pqqrppisen srsvaatipr rntlpamdns
      361 rlhrasscet yeypqrgges agrsaesmsd gvgsflpgkm ivgrsdstns ednyvpmnpg
      421 sstllamera gdnsqsvyip mspgahhfds lgypsttlpv hrgpsrgsei qpppvnrnlk
      481 pdrkakptpl dlrnntvide lpfkspitks wsranhtfns sssqycrpis tqsitstdsg
      541 dseenyvpmq npvsaspvps gtnspapkks tgsvdylald fqpsspsphr kpstssvtsd
      601 ekvdyvqvdk ektqalqntm qewtdvrqss epskgakl
//
LOCUS       XP_054226616             707 aa            linear   PRI 05-AUG-2025
DEFINITION  phospholipid transfer protein C2CD2L isoform X1 [Homo sapiens].
ACCESSION   XP_054226616
VERSION     XP_054226616.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370641.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..707
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..707
                     /product="phospholipid transfer protein C2CD2L isoform X1"
                     /calculated_mol_wt=76048
     Region          84..260
                     /region_name="SMP_C2CD2L"
                     /note="synaptotagmin-like mitochondrial-lipid-binding
                     protein (SMP) domain found in C2 domain-containing protein
                     2-like (C2CD2L); cd21683"
                     /db_xref="CDD:439239"
     Site            order(98,101..102,106,110,130,135,156,161,163,165,185,187,
                     191,193,205,207,209,219,242,245..246,251,253..256)
                     /site_type="other"
                     /note="putative lipid binding site [chemical binding]"
                     /db_xref="CDD:439239"
     Region          300..412
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     CDS             1..707
                     /gene="C2CD2L"
                     /gene_synonym="DLNB23; TMEM24"
                     /coded_by="XM_054370641.1:745..2868"
                     /db_xref="GeneID:9854"
                     /db_xref="HGNC:HGNC:29000"
                     /db_xref="MIM:617582"
ORIGIN      
        1 mdpgwgqrdv gwaallilfa aslltvfawl lqyarglwla rargdrgpgp alagepagsl
       61 relgvwrsll rlratragaa eepgvrglla slfafksfre nwqrawvral neqacrngss
      121 iqiafeevpq lpprasishv tcvdqsehtm vlrcqlsaee vrfpvsvtqq spaavsmety
      181 hvtltlpptq levnleeipg eglliswaft drpdlsltvl pklqarerge eqvelstiee
      241 likdaivstq pammvnlrac sapgglvpse kppmmpqaqp aiprpnrlfl rqlrashlgn
      301 elegteelcc vaeldnpmqq kwtkparags evewtedlal dlgpqsrelt lkvlrssscg
      361 dtellgqatl pvgspsrpls rrqlcpltpg pgkalgpaat mavelhyeeg sprnlgtpts
      421 stprpsitpt kkieldrtim pdgtivttvt tvqsrpridg kldspsrsps kvevtekttt
      481 vlsessgpsn tshssspgds hlsngldpva etairqltep sgrvakktpt krstliisgv
      541 skvpiaqdel alslgyaasl easvqddagt sggpssppsd ppamspgpld alssptsvqe
      601 adettrsdis erpsvddies etgstgalet rslkdhkvsf lrsgtklifr rrprqkeagl
      661 sqshddlsna tatpsvrkka gsfsrrlikr fsfkskpkan gnpspql
//
LOCUS       XP_054226617             670 aa            linear   PRI 05-AUG-2025
DEFINITION  phospholipid transfer protein C2CD2L isoform X2 [Homo sapiens].
ACCESSION   XP_054226617
VERSION     XP_054226617.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370642.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..670
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..670
                     /product="phospholipid transfer protein C2CD2L isoform X2"
                     /calculated_mol_wt=71903
     Region          84..223
                     /region_name="SMP_SF"
                     /note="synaptotagmin-like mitochondrial-lipid-binding
                     protein (SMP) domain superfamily; cl45903"
                     /db_xref="CDD:459248"
     Region          263..375
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     CDS             1..670
                     /gene="C2CD2L"
                     /gene_synonym="DLNB23; TMEM24"
                     /coded_by="XM_054370642.1:399..2411"
                     /db_xref="GeneID:9854"
                     /db_xref="HGNC:HGNC:29000"
                     /db_xref="MIM:617582"
ORIGIN      
        1 mdpgwgqrdv gwaallilfa aslltvfawl lqyarglwla rargdrgpgp alagepagsl
       61 relgvwrsll rlratragaa eepgvrglla slfafksfre nwqrawvral neqacrngss
      121 iqiafeevpq lpprasishv tcvdqsehtm vlrcqlsaee vrfpvsvtqq spaavsmety
      181 hvtltlpptq rgeeqvelst ieelikdaiv stqpammvnl racsapgglv psekppmmpq
      241 aqpaiprpnr lflrqlrash lgnelegtee lccvaeldnp mqqkwtkpar agsevewted
      301 laldlgpqsr eltlkvlrss scgdtellgq atlpvgspsr plsrrqlcpl tpgpgkalgp
      361 aatmavelhy eegsprnlgt ptsstprpsi tptkkieldr timpdgtivt tvttvqsrpr
      421 idgkldspsr spskvevtek tttvlsessg psntshsssp gdshlsngld pvaetairql
      481 tepsgrvakk tptkrstlii sgvskvpiaq delalslgya asleasvqdd agtsggpssp
      541 psdppamspg pldalsspts vqeadettrs diserpsvdd iesetgstga letrslkdhk
      601 vsflrsgtkl ifrrrprqke aglsqshddl snatatpsvr kkagsfsrrl ikrfsfkskp
      661 kangnpspql
//
LOCUS       XP_054226618             640 aa            linear   PRI 05-AUG-2025
DEFINITION  phospholipid transfer protein C2CD2L isoform X3 [Homo sapiens].
ACCESSION   XP_054226618
VERSION     XP_054226618.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370643.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..640
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..640
                     /product="phospholipid transfer protein C2CD2L isoform X3"
                     /calculated_mol_wt=68763
     Region          84..260
                     /region_name="SMP_C2CD2L"
                     /note="synaptotagmin-like mitochondrial-lipid-binding
                     protein (SMP) domain found in C2 domain-containing protein
                     2-like (C2CD2L); cd21683"
                     /db_xref="CDD:439239"
     Site            order(98,101..102,106,110,130,135,156,161,163,165,185,187,
                     191,193,205,207,209,219,242,245..246,251,253..256)
                     /site_type="other"
                     /note="putative lipid binding site [chemical binding]"
                     /db_xref="CDD:439239"
     Region          300..409
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     CDS             1..640
                     /gene="C2CD2L"
                     /gene_synonym="DLNB23; TMEM24"
                     /coded_by="XM_054370643.1:399..2321"
                     /db_xref="GeneID:9854"
                     /db_xref="HGNC:HGNC:29000"
                     /db_xref="MIM:617582"
ORIGIN      
        1 mdpgwgqrdv gwaallilfa aslltvfawl lqyarglwla rargdrgpgp alagepagsl
       61 relgvwrsll rlratragaa eepgvrglla slfafksfre nwqrawvral neqacrngss
      121 iqiafeevpq lpprasishv tcvdqsehtm vlrcqlsaee vrfpvsvtqq spaavsmety
      181 hvtltlpptq levnleeipg eglliswaft drpdlsltvl pklqarerge eqvelstiee
      241 likdaivstq pammvnlrac sapgglvpse kppmmpqaqp aiprpnrlfl rqlrashlgn
      301 elegteelcc vaeldnpmqq kwtkparags evewtedlal dlgpqsrelt lkvlrssscg
      361 dtellgqatl pvgspsrpls rrqlcpltpg pgkalgpaat mavevevtek tttvlsessg
      421 psntshsssp gdshlsngld pvaetairql tepsgrvakk tptkrstlii sgvskvpiaq
      481 delalslgya asleasvqdd agtsggpssp psdppamspg pldalsspts vqeadettrs
      541 diserpsvdd iesetgstga letrslkdhk vsflrsgtkl ifrrrprqke aglsqshddl
      601 snatatpsvr kkagsfsrrl ikrfsfkskp kangnpspql
//
LOCUS       XP_054226619             639 aa            linear   PRI 05-AUG-2025
DEFINITION  phospholipid transfer protein C2CD2L isoform X4 [Homo sapiens].
ACCESSION   XP_054226619
VERSION     XP_054226619.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370644.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..639
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..639
                     /product="phospholipid transfer protein C2CD2L isoform X4"
                     /calculated_mol_wt=68765
     Region          84..260
                     /region_name="SMP_C2CD2L"
                     /note="synaptotagmin-like mitochondrial-lipid-binding
                     protein (SMP) domain found in C2 domain-containing protein
                     2-like (C2CD2L); cd21683"
                     /db_xref="CDD:439239"
     Site            order(98,101..102,106,110,130,135,156,161,163,165,185,187,
                     191,193,205,207,209,219,242,245..246,251,253..256)
                     /site_type="other"
                     /note="putative lipid binding site [chemical binding]"
                     /db_xref="CDD:439239"
     Region          300..409
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     CDS             1..639
                     /gene="C2CD2L"
                     /gene_synonym="DLNB23; TMEM24"
                     /coded_by="XM_054370644.1:399..2318"
                     /db_xref="GeneID:9854"
                     /db_xref="HGNC:HGNC:29000"
                     /db_xref="MIM:617582"
ORIGIN      
        1 mdpgwgqrdv gwaallilfa aslltvfawl lqyarglwla rargdrgpgp alagepagsl
       61 relgvwrsll rlratragaa eepgvrglla slfafksfre nwqrawvral neqacrngss
      121 iqiafeevpq lpprasishv tcvdqsehtm vlrcqlsaee vrfpvsvtqq spaavsmety
      181 hvtltlpptq levnleeipg eglliswaft drpdlsltvl pklqarerge eqvelstiee
      241 likdaivstq pammvnlrac sapgglvpse kppmmpqaqp aiprpnrlfl rqlrashlgn
      301 elegteelcc vaeldnpmqq kwtkparags evewtedlal dlgpqsrelt lkvlrssscg
      361 dtellgqatl pvgspsrpls rrqlcpltpg pgkalgpaat mavevevtek tttvlsessg
      421 psntshsssr dshlsngldp vaetairqlt epsgrvakkt ptkrstliis gvskvpiaqd
      481 elalslgyaa sleasvqdda gtsggpsspp sdppamspgp ldalssptsv qeadettrsd
      541 iserpsvddi esetgstgal etrslkdhkv sflrsgtkli frrrprqkea glsqshddls
      601 natatpsvrk kagsfsrrli krfsfkskpk angnpspql
//
LOCUS       XP_054226620             558 aa            linear   PRI 05-AUG-2025
DEFINITION  phospholipid transfer protein C2CD2L isoform X5 [Homo sapiens].
ACCESSION   XP_054226620
VERSION     XP_054226620.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370645.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..558
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..558
                     /product="phospholipid transfer protein C2CD2L isoform X5"
                     /calculated_mol_wt=59675
     Region          <1..111
                     /region_name="SMP_SF"
                     /note="synaptotagmin-like mitochondrial-lipid-binding
                     protein (SMP) domain superfamily; cl45903"
                     /db_xref="CDD:459248"
     Region          151..263
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     CDS             1..558
                     /gene="C2CD2L"
                     /gene_synonym="DLNB23; TMEM24"
                     /coded_by="XM_054370645.1:1336..3012"
                     /db_xref="GeneID:9854"
                     /db_xref="HGNC:HGNC:29000"
                     /db_xref="MIM:617582"
ORIGIN      
        1 mvlrcqlsae evrfpvsvtq qspaavsmet yhvtltlppt qlevnleeip geglliswaf
       61 tdrpdlsltv lpklqarerg eeqvelstie elikdaivst qpammvnlra csapgglvps
      121 ekppmmpqaq paiprpnrlf lrqlrashlg nelegteelc cvaeldnpmq qkwtkparag
      181 sevewtedla ldlgpqsrel tlkvlrsssc gdtellgqat lpvgspsrpl srrqlcpltp
      241 gpgkalgpaa tmavelhyee gsprnlgtpt sstprpsitp tkkieldrti mpdgtivttv
      301 ttvqsrprid gkldspsrsp skvevtektt tvlsessgps ntshssspgd shlsngldpv
      361 aetairqlte psgrvakktp tkrstliisg vskvpiaqde lalslgyaas leasvqddag
      421 tsggpsspps dppamspgpl dalssptsvq eadettrsdi serpsvddie setgstgale
      481 trslkdhkvs flrsgtklif rrrprqkeag lsqshddlsn atatpsvrkk agsfsrrlik
      541 rfsfkskpka ngnpspql
//
LOCUS       XP_054226621             474 aa            linear   PRI 05-AUG-2025
DEFINITION  phospholipid transfer protein C2CD2L isoform X6 [Homo sapiens].
ACCESSION   XP_054226621
VERSION     XP_054226621.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370646.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..474
                     /product="phospholipid transfer protein C2CD2L isoform X6"
                     /calculated_mol_wt=51536
     Region          84..260
                     /region_name="SMP_C2CD2L"
                     /note="synaptotagmin-like mitochondrial-lipid-binding
                     protein (SMP) domain found in C2 domain-containing protein
                     2-like (C2CD2L); cd21683"
                     /db_xref="CDD:439239"
     Site            order(98,101..102,106,110,130,135,156,161,163,165,185,187,
                     191,193,205,207,209,219,242,245..246,251,253..256)
                     /site_type="other"
                     /note="putative lipid binding site [chemical binding]"
                     /db_xref="CDD:439239"
     Region          300..412
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     CDS             1..474
                     /gene="C2CD2L"
                     /gene_synonym="DLNB23; TMEM24"
                     /coded_by="XM_054370646.1:399..1823"
                     /db_xref="GeneID:9854"
                     /db_xref="HGNC:HGNC:29000"
                     /db_xref="MIM:617582"
ORIGIN      
        1 mdpgwgqrdv gwaallilfa aslltvfawl lqyarglwla rargdrgpgp alagepagsl
       61 relgvwrsll rlratragaa eepgvrglla slfafksfre nwqrawvral neqacrngss
      121 iqiafeevpq lpprasishv tcvdqsehtm vlrcqlsaee vrfpvsvtqq spaavsmety
      181 hvtltlpptq levnleeipg eglliswaft drpdlsltvl pklqarerge eqvelstiee
      241 likdaivstq pammvnlrac sapgglvpse kppmmpqaqp aiprpnrlfl rqlrashlgn
      301 elegteelcc vaeldnpmqq kwtkparags evewtedlal dlgpqsrelt lkvlrssscg
      361 dtellgqatl pvgspsrpls rrqlcpltpg pgkalgpaat mavelhyeeg sprnlgtpts
      421 stprpsitpt kkieldrtim pdgtivttvt tvqsrpridg klgggdredd ncae
//
LOCUS       XP_054226622             474 aa            linear   PRI 05-AUG-2025
DEFINITION  phospholipid transfer protein C2CD2L isoform X6 [Homo sapiens].
ACCESSION   XP_054226622
VERSION     XP_054226622.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370647.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..474
                     /product="phospholipid transfer protein C2CD2L isoform X6"
                     /calculated_mol_wt=51536
     Region          84..260
                     /region_name="SMP_C2CD2L"
                     /note="synaptotagmin-like mitochondrial-lipid-binding
                     protein (SMP) domain found in C2 domain-containing protein
                     2-like (C2CD2L); cd21683"
                     /db_xref="CDD:439239"
     Site            order(98,101..102,106,110,130,135,156,161,163,165,185,187,
                     191,193,205,207,209,219,242,245..246,251,253..256)
                     /site_type="other"
                     /note="putative lipid binding site [chemical binding]"
                     /db_xref="CDD:439239"
     Region          300..412
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     CDS             1..474
                     /gene="C2CD2L"
                     /gene_synonym="DLNB23; TMEM24"
                     /coded_by="XM_054370647.1:399..1823"
                     /db_xref="GeneID:9854"
                     /db_xref="HGNC:HGNC:29000"
                     /db_xref="MIM:617582"
ORIGIN      
        1 mdpgwgqrdv gwaallilfa aslltvfawl lqyarglwla rargdrgpgp alagepagsl
       61 relgvwrsll rlratragaa eepgvrglla slfafksfre nwqrawvral neqacrngss
      121 iqiafeevpq lpprasishv tcvdqsehtm vlrcqlsaee vrfpvsvtqq spaavsmety
      181 hvtltlpptq levnleeipg eglliswaft drpdlsltvl pklqarerge eqvelstiee
      241 likdaivstq pammvnlrac sapgglvpse kppmmpqaqp aiprpnrlfl rqlrashlgn
      301 elegteelcc vaeldnpmqq kwtkparags evewtedlal dlgpqsrelt lkvlrssscg
      361 dtellgqatl pvgspsrpls rrqlcpltpg pgkalgpaat mavelhyeeg sprnlgtpts
      421 stprpsitpt kkieldrtim pdgtivttvt tvqsrpridg klgggdredd ncae
//
LOCUS       XP_054226623            1392 aa            linear   PRI 05-AUG-2025
DEFINITION  tripartite motif-containing protein 66 isoform X1 [Homo sapiens].
ACCESSION   XP_054226623
VERSION     XP_054226623.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370648.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1392
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1392
                     /product="tripartite motif-containing protein 66 isoform
                     X1"
                     /calculated_mol_wt=153719
     Region          149..185
                     /region_name="Bbox1_TRIM66"
                     /note="B-box-type 1 zinc finger found in tripartite
                     motif-containing protein 66 (TRIM66) and similar proteins;
                     cd19811"
                     /db_xref="CDD:380869"
     Region          208..250
                     /region_name="Bbox2_TRIM66-like"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing protein 66 (TRIM66) and similar proteins;
                     cd19794"
                     /db_xref="CDD:380852"
     Region          253..378
                     /region_name="BBC"
                     /note="B-Box C-terminal domain; smart00502"
                     /db_xref="CDD:128778"
     Region          1145..1193
                     /region_name="PHD_SF"
                     /note="PHD finger superfamily; cl22851"
                     /db_xref="CDD:473978"
     Site            order(1148,1158..1161,1165,1185)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:277095"
     Region          1218..1326
                     /region_name="Bromo_tif1_like"
                     /note="Bromodomain; tif1_like subfamily. Tif1
                     (transcription intermediary factor 1) is a member of the
                     tripartite motif (TRIM) protein family, which is
                     characterized by a particular domain architecture. It
                     functions by recruiting coactivators and/or...; cd05502"
                     /db_xref="CDD:99934"
     Site            order(1246,1250,1253,1295,1299,1305)
                     /site_type="other"
                     /note="putative acetyllysine binding site [chemical
                     binding]"
                     /db_xref="CDD:99934"
     CDS             1..1392
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /coded_by="XM_054370648.1:649..4827"
                     /db_xref="GeneID:9866"
                     /db_xref="HGNC:HGNC:29005"
                     /db_xref="MIM:612000"
ORIGIN      
        1 marlsfwsqg velarstrcf spedisgkap vlgtgmavdm gmsfmglpla gqkhcpksgq
       61 meamvmtcsl chqdlpgmgs hllscqhllr kdcfqgliqe lgqiakahet vadeliscpg
      121 cervyltrdv tehfflhcvp teqpkmarnc seckekraah ilctycnrwl csscteehrh
      181 spvpggpffp raqkgspgvn ggpgdftlyc plhtqevlkl fcetcdmltc hsclvvehke
      241 hrcrhveevl qnqrmllegv ttqvahkkss lqtsakqied rifevkhqhr kvenqikmak
      301 mvlmnelnkq anglieeleg itnerkrkle qqlqsimvln rqfehvqnfi nwavcsktsv
      361 pflfskeliv fqmqrllets cntdpgspws irftwepnfw tkqlaslgci tteggqmsra
      421 dapaygglqg sspfyqshqs pvaqqealsh pshkfqspav csssvccsrc spvspslkgq
      481 vpppsihpah sfrqppemvp qqlgslqcsa llprekelac sphppkllqp wletqppveq
      541 estsqrlgqq ltsqpvcivp pqdvqqgaha qptlqtpsiq vqfghhqklk lshfqqqpqq
      601 qlpppppplp rpppplpppp qqphpplpps qhlassqhes ppgpacsqnm dimhhkfele
      661 emqkdlelll qaqqpslqls qtkspqhlqq tivgqinyiv rqpapvqsqs qeetlqatde
      721 ppasqgskpa lpldkntaaa lpqasgeetp lsvppvdsti qhsspnvvrk hstslsimgf
      781 sntlemelss trlerplepq iqsvsnltag apqavpslls appkmvsslt svqnqampsl
      841 ttshlqtvps lvhstfqsmp nlisdspqam aslasdhpqa gpslmsghtq avpslatcpl
      901 qsippvsdmq petgsssssg rtsgslcprd gadpslenal ckmesedstr ftdllgqgpi
      961 vpgldapkdl aipseleepi nlsvkkppla pvvststalq qyqnpkecen feqgalelda
     1021 kenqsirafn sehkipyvrl erlkicaass gempvfklkp qkndqdgsfl liiecgtess
     1081 smsikvsqdr lseatqapgl egrkvtvtsl agqrppeveg tspeehrlip rtpgakkgpp
     1141 apienedfca vclnggellc cdrcpkvfhl schvpallsf pggewvctlc rsltqpemey
     1201 dcenacynqp gmraspglsm ydqkkceklv lslccnnlsl pfhepvspla rhyyqiikrp
     1261 mdlsiirrkl qkkdpahytt peevvsdvrl mfwncakfny pdsevaeagr clevffegwl
     1321 keiypekrfa qprqedsdse evssesgcst pqgfpwppym qegiqpkrrr rhmenerakr
     1381 msfrlansis qv
//
LOCUS       XP_054226624            1392 aa            linear   PRI 05-AUG-2025
DEFINITION  tripartite motif-containing protein 66 isoform X1 [Homo sapiens].
ACCESSION   XP_054226624
VERSION     XP_054226624.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370649.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1392
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1392
                     /product="tripartite motif-containing protein 66 isoform
                     X1"
                     /calculated_mol_wt=153719
     Region          149..185
                     /region_name="Bbox1_TRIM66"
                     /note="B-box-type 1 zinc finger found in tripartite
                     motif-containing protein 66 (TRIM66) and similar proteins;
                     cd19811"
                     /db_xref="CDD:380869"
     Region          208..250
                     /region_name="Bbox2_TRIM66-like"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing protein 66 (TRIM66) and similar proteins;
                     cd19794"
                     /db_xref="CDD:380852"
     Region          253..378
                     /region_name="BBC"
                     /note="B-Box C-terminal domain; smart00502"
                     /db_xref="CDD:128778"
     Region          1145..1193
                     /region_name="PHD_SF"
                     /note="PHD finger superfamily; cl22851"
                     /db_xref="CDD:473978"
     Site            order(1148,1158..1161,1165,1185)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:277095"
     Region          1218..1326
                     /region_name="Bromo_tif1_like"
                     /note="Bromodomain; tif1_like subfamily. Tif1
                     (transcription intermediary factor 1) is a member of the
                     tripartite motif (TRIM) protein family, which is
                     characterized by a particular domain architecture. It
                     functions by recruiting coactivators and/or...; cd05502"
                     /db_xref="CDD:99934"
     Site            order(1246,1250,1253,1295,1299,1305)
                     /site_type="other"
                     /note="putative acetyllysine binding site [chemical
                     binding]"
                     /db_xref="CDD:99934"
     CDS             1..1392
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /coded_by="XM_054370649.1:546..4724"
                     /db_xref="GeneID:9866"
                     /db_xref="HGNC:HGNC:29005"
                     /db_xref="MIM:612000"
ORIGIN      
        1 marlsfwsqg velarstrcf spedisgkap vlgtgmavdm gmsfmglpla gqkhcpksgq
       61 meamvmtcsl chqdlpgmgs hllscqhllr kdcfqgliqe lgqiakahet vadeliscpg
      121 cervyltrdv tehfflhcvp teqpkmarnc seckekraah ilctycnrwl csscteehrh
      181 spvpggpffp raqkgspgvn ggpgdftlyc plhtqevlkl fcetcdmltc hsclvvehke
      241 hrcrhveevl qnqrmllegv ttqvahkkss lqtsakqied rifevkhqhr kvenqikmak
      301 mvlmnelnkq anglieeleg itnerkrkle qqlqsimvln rqfehvqnfi nwavcsktsv
      361 pflfskeliv fqmqrllets cntdpgspws irftwepnfw tkqlaslgci tteggqmsra
      421 dapaygglqg sspfyqshqs pvaqqealsh pshkfqspav csssvccsrc spvspslkgq
      481 vpppsihpah sfrqppemvp qqlgslqcsa llprekelac sphppkllqp wletqppveq
      541 estsqrlgqq ltsqpvcivp pqdvqqgaha qptlqtpsiq vqfghhqklk lshfqqqpqq
      601 qlpppppplp rpppplpppp qqphpplpps qhlassqhes ppgpacsqnm dimhhkfele
      661 emqkdlelll qaqqpslqls qtkspqhlqq tivgqinyiv rqpapvqsqs qeetlqatde
      721 ppasqgskpa lpldkntaaa lpqasgeetp lsvppvdsti qhsspnvvrk hstslsimgf
      781 sntlemelss trlerplepq iqsvsnltag apqavpslls appkmvsslt svqnqampsl
      841 ttshlqtvps lvhstfqsmp nlisdspqam aslasdhpqa gpslmsghtq avpslatcpl
      901 qsippvsdmq petgsssssg rtsgslcprd gadpslenal ckmesedstr ftdllgqgpi
      961 vpgldapkdl aipseleepi nlsvkkppla pvvststalq qyqnpkecen feqgalelda
     1021 kenqsirafn sehkipyvrl erlkicaass gempvfklkp qkndqdgsfl liiecgtess
     1081 smsikvsqdr lseatqapgl egrkvtvtsl agqrppeveg tspeehrlip rtpgakkgpp
     1141 apienedfca vclnggellc cdrcpkvfhl schvpallsf pggewvctlc rsltqpemey
     1201 dcenacynqp gmraspglsm ydqkkceklv lslccnnlsl pfhepvspla rhyyqiikrp
     1261 mdlsiirrkl qkkdpahytt peevvsdvrl mfwncakfny pdsevaeagr clevffegwl
     1321 keiypekrfa qprqedsdse evssesgcst pqgfpwppym qegiqpkrrr rhmenerakr
     1381 msfrlansis qv
//
LOCUS       XP_054226625            1392 aa            linear   PRI 05-AUG-2025
DEFINITION  tripartite motif-containing protein 66 isoform X1 [Homo sapiens].
ACCESSION   XP_054226625
VERSION     XP_054226625.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370650.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1392
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1392
                     /product="tripartite motif-containing protein 66 isoform
                     X1"
                     /calculated_mol_wt=153719
     Region          149..185
                     /region_name="Bbox1_TRIM66"
                     /note="B-box-type 1 zinc finger found in tripartite
                     motif-containing protein 66 (TRIM66) and similar proteins;
                     cd19811"
                     /db_xref="CDD:380869"
     Region          208..250
                     /region_name="Bbox2_TRIM66-like"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing protein 66 (TRIM66) and similar proteins;
                     cd19794"
                     /db_xref="CDD:380852"
     Region          253..378
                     /region_name="BBC"
                     /note="B-Box C-terminal domain; smart00502"
                     /db_xref="CDD:128778"
     Region          1145..1193
                     /region_name="PHD_SF"
                     /note="PHD finger superfamily; cl22851"
                     /db_xref="CDD:473978"
     Site            order(1148,1158..1161,1165,1185)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:277095"
     Region          1218..1326
                     /region_name="Bromo_tif1_like"
                     /note="Bromodomain; tif1_like subfamily. Tif1
                     (transcription intermediary factor 1) is a member of the
                     tripartite motif (TRIM) protein family, which is
                     characterized by a particular domain architecture. It
                     functions by recruiting coactivators and/or...; cd05502"
                     /db_xref="CDD:99934"
     Site            order(1246,1250,1253,1295,1299,1305)
                     /site_type="other"
                     /note="putative acetyllysine binding site [chemical
                     binding]"
                     /db_xref="CDD:99934"
     CDS             1..1392
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /coded_by="XM_054370650.1:1013..5191"
                     /db_xref="GeneID:9866"
                     /db_xref="HGNC:HGNC:29005"
                     /db_xref="MIM:612000"
ORIGIN      
        1 marlsfwsqg velarstrcf spedisgkap vlgtgmavdm gmsfmglpla gqkhcpksgq
       61 meamvmtcsl chqdlpgmgs hllscqhllr kdcfqgliqe lgqiakahet vadeliscpg
      121 cervyltrdv tehfflhcvp teqpkmarnc seckekraah ilctycnrwl csscteehrh
      181 spvpggpffp raqkgspgvn ggpgdftlyc plhtqevlkl fcetcdmltc hsclvvehke
      241 hrcrhveevl qnqrmllegv ttqvahkkss lqtsakqied rifevkhqhr kvenqikmak
      301 mvlmnelnkq anglieeleg itnerkrkle qqlqsimvln rqfehvqnfi nwavcsktsv
      361 pflfskeliv fqmqrllets cntdpgspws irftwepnfw tkqlaslgci tteggqmsra
      421 dapaygglqg sspfyqshqs pvaqqealsh pshkfqspav csssvccsrc spvspslkgq
      481 vpppsihpah sfrqppemvp qqlgslqcsa llprekelac sphppkllqp wletqppveq
      541 estsqrlgqq ltsqpvcivp pqdvqqgaha qptlqtpsiq vqfghhqklk lshfqqqpqq
      601 qlpppppplp rpppplpppp qqphpplpps qhlassqhes ppgpacsqnm dimhhkfele
      661 emqkdlelll qaqqpslqls qtkspqhlqq tivgqinyiv rqpapvqsqs qeetlqatde
      721 ppasqgskpa lpldkntaaa lpqasgeetp lsvppvdsti qhsspnvvrk hstslsimgf
      781 sntlemelss trlerplepq iqsvsnltag apqavpslls appkmvsslt svqnqampsl
      841 ttshlqtvps lvhstfqsmp nlisdspqam aslasdhpqa gpslmsghtq avpslatcpl
      901 qsippvsdmq petgsssssg rtsgslcprd gadpslenal ckmesedstr ftdllgqgpi
      961 vpgldapkdl aipseleepi nlsvkkppla pvvststalq qyqnpkecen feqgalelda
     1021 kenqsirafn sehkipyvrl erlkicaass gempvfklkp qkndqdgsfl liiecgtess
     1081 smsikvsqdr lseatqapgl egrkvtvtsl agqrppeveg tspeehrlip rtpgakkgpp
     1141 apienedfca vclnggellc cdrcpkvfhl schvpallsf pggewvctlc rsltqpemey
     1201 dcenacynqp gmraspglsm ydqkkceklv lslccnnlsl pfhepvspla rhyyqiikrp
     1261 mdlsiirrkl qkkdpahytt peevvsdvrl mfwncakfny pdsevaeagr clevffegwl
     1321 keiypekrfa qprqedsdse evssesgcst pqgfpwppym qegiqpkrrr rhmenerakr
     1381 msfrlansis qv
//
LOCUS       XP_054226626            1385 aa            linear   PRI 05-AUG-2025
DEFINITION  tripartite motif-containing protein 66 isoform X2 [Homo sapiens].
ACCESSION   XP_054226626
VERSION     XP_054226626.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370651.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1385
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1385
                     /product="tripartite motif-containing protein 66 isoform
                     X2"
                     /calculated_mol_wt=152719
     Region          149..185
                     /region_name="Bbox1_TRIM66"
                     /note="B-box-type 1 zinc finger found in tripartite
                     motif-containing protein 66 (TRIM66) and similar proteins;
                     cd19811"
                     /db_xref="CDD:380869"
     Region          208..250
                     /region_name="Bbox2_TRIM66-like"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing protein 66 (TRIM66) and similar proteins;
                     cd19794"
                     /db_xref="CDD:380852"
     Region          253..378
                     /region_name="BBC"
                     /note="B-Box C-terminal domain; smart00502"
                     /db_xref="CDD:128778"
     Region          1145..1193
                     /region_name="PHD_SF"
                     /note="PHD finger superfamily; cl22851"
                     /db_xref="CDD:473978"
     Site            order(1148,1158..1161,1165,1185)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:276966"
     Region          1218..1326
                     /region_name="Bromo_tif1_like"
                     /note="Bromodomain; tif1_like subfamily. Tif1
                     (transcription intermediary factor 1) is a member of the
                     tripartite motif (TRIM) protein family, which is
                     characterized by a particular domain architecture. It
                     functions by recruiting coactivators and/or...; cd05502"
                     /db_xref="CDD:99934"
     Site            order(1246,1250,1253,1295,1299,1305)
                     /site_type="other"
                     /note="putative acetyllysine binding site [chemical
                     binding]"
                     /db_xref="CDD:99934"
     CDS             1..1385
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /coded_by="XM_054370651.1:613..4770"
                     /db_xref="GeneID:9866"
                     /db_xref="HGNC:HGNC:29005"
                     /db_xref="MIM:612000"
ORIGIN      
        1 marlsfwsqg velarstrcf spedisgkap vlgtgmavdm gmsfmglpla gqkhcpksgq
       61 meamvmtcsl chqdlpgmgs hllscqhllr kdcfqgliqe lgqiakahet vadeliscpg
      121 cervyltrdv tehfflhcvp teqpkmarnc seckekraah ilctycnrwl csscteehrh
      181 spvpggpffp raqkgspgvn ggpgdftlyc plhtqevlkl fcetcdmltc hsclvvehke
      241 hrcrhveevl qnqrmllegv ttqvahkkss lqtsakqied rifevkhqhr kvenqikmak
      301 mvlmnelnkq anglieeleg itnerkrkle qqlqsimvln rqfehvqnfi nwavcsktsv
      361 pflfskeliv fqmqrllets cntdpgspws irftwepnfw tkqlaslgci tteggqmsra
      421 dapaygglqg sspfyqshqs pvaqqealsh pshkfqspav csssvccsrc spvspslkgq
      481 vpppsihpah sfrqppemvp qqlgslqcsa llprekelac sphppkllqp wletqppveq
      541 estsqrlgqq ltsqpvcivp pqdvqqgaha qptlqtpsiq vqfghhqklk lshfqqqpqq
      601 qlpppppplp rpppplpppp qqphpplpps qhlassqhes ppgpacsqnm dimhhkfele
      661 emqkdlelll qaqqpslqls qtkspqhlqq tivgqinyiv rqpapvqsqs qeetlqatde
      721 ppasqgskpa lpldkntaaa lpqasgeetp lsvppvdsti qhsspnvvrk hstslsimgf
      781 sntlemelss trlerplepq iqsvsnltag apqavpslls appkmvsslt svqnqampsl
      841 ttshlqtvps lvhstfqsmp nlisdspqam aslasdhpqa gpslmsghtq avpslatcpl
      901 qsippvsdmq petgsssssg rtsgslcprd gadpslenal ckmesedstr ftdllgqgpi
      961 vpgldapkdl aipseleepi nlsvkkppla pvvststalq qyqnpkecen feqgalelda
     1021 kenqsirafn sehkipyvrl erlkicaass gempvfklkp qkndqdgsfl liiecgtess
     1081 smsikvsqdr lseatqapgl egrkvtvtsl agqrppeveg tspeehrlip rtpgakkgpp
     1141 apienedfca vclnggellc cdrcpkvfhl schvpallsf pggewvctlc rsltqpemey
     1201 dcenacynqp gmraspglsm ydqkkceklv lslccnnlsl pfhepvspla rhyyqiikrp
     1261 mdlsiirrkl qkkdpahytt peevvsdvrl mfwncakfny pdsevaeagr clevffegwl
     1321 keiypekrfa qprqedsdse evssesgcst pqgfpwppym qegiqpkrrr rhmvksycqp
     1381 aaggr
//
LOCUS       XP_054226627            1367 aa            linear   PRI 05-AUG-2025
DEFINITION  tripartite motif-containing protein 66 isoform X3 [Homo sapiens].
ACCESSION   XP_054226627
VERSION     XP_054226627.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370652.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1367
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1367
                     /product="tripartite motif-containing protein 66 isoform
                     X3"
                     /calculated_mol_wt=150953
     Region          149..185
                     /region_name="Bbox1_TRIM66"
                     /note="B-box-type 1 zinc finger found in tripartite
                     motif-containing protein 66 (TRIM66) and similar proteins;
                     cd19811"
                     /db_xref="CDD:380869"
     Region          208..250
                     /region_name="Bbox2_TRIM66-like"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing protein 66 (TRIM66) and similar proteins;
                     cd19794"
                     /db_xref="CDD:380852"
     Region          253..378
                     /region_name="BBC"
                     /note="B-Box C-terminal domain; smart00502"
                     /db_xref="CDD:128778"
     Region          1145..1193
                     /region_name="PHD_SF"
                     /note="PHD finger superfamily; cl22851"
                     /db_xref="CDD:473978"
     Site            order(1148,1158..1161,1165,1185)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:276966"
     Region          <1225..1301
                     /region_name="Bromodomain"
                     /note="Bromodomains are found in many chromatin-associated
                     proteins and in nuclear histone acetyltransferases. They
                     interact specifically with acetylated lysine; cl02556"
                     /db_xref="CDD:445827"
     Site            order(1225,1228,1270,1274,1280)
                     /site_type="active"
                     /note="acetyllysine binding site [active]"
                     /db_xref="CDD:99934"
     CDS             1..1367
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /coded_by="XM_054370652.1:613..4716"
                     /db_xref="GeneID:9866"
                     /db_xref="HGNC:HGNC:29005"
                     /db_xref="MIM:612000"
ORIGIN      
        1 marlsfwsqg velarstrcf spedisgkap vlgtgmavdm gmsfmglpla gqkhcpksgq
       61 meamvmtcsl chqdlpgmgs hllscqhllr kdcfqgliqe lgqiakahet vadeliscpg
      121 cervyltrdv tehfflhcvp teqpkmarnc seckekraah ilctycnrwl csscteehrh
      181 spvpggpffp raqkgspgvn ggpgdftlyc plhtqevlkl fcetcdmltc hsclvvehke
      241 hrcrhveevl qnqrmllegv ttqvahkkss lqtsakqied rifevkhqhr kvenqikmak
      301 mvlmnelnkq anglieeleg itnerkrkle qqlqsimvln rqfehvqnfi nwavcsktsv
      361 pflfskeliv fqmqrllets cntdpgspws irftwepnfw tkqlaslgci tteggqmsra
      421 dapaygglqg sspfyqshqs pvaqqealsh pshkfqspav csssvccsrc spvspslkgq
      481 vpppsihpah sfrqppemvp qqlgslqcsa llprekelac sphppkllqp wletqppveq
      541 estsqrlgqq ltsqpvcivp pqdvqqgaha qptlqtpsiq vqfghhqklk lshfqqqpqq
      601 qlpppppplp rpppplpppp qqphpplpps qhlassqhes ppgpacsqnm dimhhkfele
      661 emqkdlelll qaqqpslqls qtkspqhlqq tivgqinyiv rqpapvqsqs qeetlqatde
      721 ppasqgskpa lpldkntaaa lpqasgeetp lsvppvdsti qhsspnvvrk hstslsimgf
      781 sntlemelss trlerplepq iqsvsnltag apqavpslls appkmvsslt svqnqampsl
      841 ttshlqtvps lvhstfqsmp nlisdspqam aslasdhpqa gpslmsghtq avpslatcpl
      901 qsippvsdmq petgsssssg rtsgslcprd gadpslenal ckmesedstr ftdllgqgpi
      961 vpgldapkdl aipseleepi nlsvkkppla pvvststalq qyqnpkecen feqgalelda
     1021 kenqsirafn sehkipyvrl erlkicaass gempvfklkp qkndqdgsfl liiecgtess
     1081 smsikvsqdr lseatqapgl egrkvtvtsl agqrppeveg tspeehrlip rtpgakkgpp
     1141 apienedfca vclnggellc cdrcpkvfhl schvpallsf pggewvctlc rsltqpemey
     1201 dcenacynqp gmraspglsm ydqkarhyyq iikrpmdlsi irrklqkkdp ahyttpeevv
     1261 sdvrlmfwnc akfnypdsev aeagrclevf fegwlkeiyp ekrfaqprqe dsdseevsse
     1321 sgcstpqgfp wppymqegiq pkrrrrhmen erakrmsfrl ansisqv
//
LOCUS       XP_054226628            1364 aa            linear   PRI 05-AUG-2025
DEFINITION  tripartite motif-containing protein 66 isoform X4 [Homo sapiens].
ACCESSION   XP_054226628
VERSION     XP_054226628.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370653.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1364
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1364
                     /product="tripartite motif-containing protein 66 isoform
                     X4"
                     /calculated_mol_wt=150838
     Region          149..185
                     /region_name="Bbox1_TRIM66"
                     /note="B-box-type 1 zinc finger found in tripartite
                     motif-containing protein 66 (TRIM66) and similar proteins;
                     cd19811"
                     /db_xref="CDD:380869"
     Region          208..250
                     /region_name="Bbox2_TRIM66-like"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing protein 66 (TRIM66) and similar proteins;
                     cd19794"
                     /db_xref="CDD:380852"
     Region          253..378
                     /region_name="BBC"
                     /note="B-Box C-terminal domain; smart00502"
                     /db_xref="CDD:128778"
     Region          710..909
                     /region_name="rad23"
                     /note="UV excision repair protein Rad23; TIGR00601"
                     /db_xref="CDD:273167"
     Region          1117..1165
                     /region_name="PHD_SF"
                     /note="PHD finger superfamily; cl22851"
                     /db_xref="CDD:473978"
     Site            order(1120,1130..1133,1137,1157)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:276966"
     Region          1190..1298
                     /region_name="Bromo_tif1_like"
                     /note="Bromodomain; tif1_like subfamily. Tif1
                     (transcription intermediary factor 1) is a member of the
                     tripartite motif (TRIM) protein family, which is
                     characterized by a particular domain architecture. It
                     functions by recruiting coactivators and/or...; cd05502"
                     /db_xref="CDD:99934"
     Site            order(1218,1222,1225,1267,1271,1277)
                     /site_type="other"
                     /note="putative acetyllysine binding site [chemical
                     binding]"
                     /db_xref="CDD:99934"
     CDS             1..1364
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /coded_by="XM_054370653.1:613..4707"
                     /db_xref="GeneID:9866"
                     /db_xref="HGNC:HGNC:29005"
                     /db_xref="MIM:612000"
ORIGIN      
        1 marlsfwsqg velarstrcf spedisgkap vlgtgmavdm gmsfmglpla gqkhcpksgq
       61 meamvmtcsl chqdlpgmgs hllscqhllr kdcfqgliqe lgqiakahet vadeliscpg
      121 cervyltrdv tehfflhcvp teqpkmarnc seckekraah ilctycnrwl csscteehrh
      181 spvpggpffp raqkgspgvn ggpgdftlyc plhtqevlkl fcetcdmltc hsclvvehke
      241 hrcrhveevl qnqrmllegv ttqvahkkss lqtsakqied rifevkhqhr kvenqikmak
      301 mvlmnelnkq anglieeleg itnerkrkle qqlqsimvln rqfehvqnfi nwavcsktsv
      361 pflfskeliv fqmqrllets cntdpgspws irftwepnfw tkqlaslgci tteggqmsra
      421 dapaygglqg sspfyqshqs pvaqqealsh pshkfqspav csssvccsrc spvspslkgq
      481 vpppsihpah sfrqppemvp qqlgslqcsa llprekelac sphppkllqp wletqppveq
      541 estsqrlgqq ltsqpvcivp pqdvqqgaha qptlqtpsiq vqfghhqklk lshfqqqpqq
      601 qlpppppplp rpppplpppp qqphpplpps qhlassqhes ppgpacsqnm dimhhkfele
      661 emqkdlelll qaqqpslqls qtkspqhlqq tivgqinyiv rqpapvqsqs qeetlqatde
      721 ppasqgskpa lpldkntaaa lpqasgeetp lsvppvdsti qhsspnvvrk hstslsimgf
      781 sntlemelss trlerplepq iqsvsnltag apqavpslls appkmvsslt svqnqampsl
      841 ttshlqtvps lvhstfqsmp nlisdspqam aslasdhpqa gpslmsghtq avpslatcpl
      901 qsippvsdmq petgsssssg rtsgslcprd gadpslenal ckmesedstr ftdllgqgpi
      961 vpgldapkdl aipseleepi nlsvkkppla pvvststalq qyqnpkecen feqgalelda
     1021 kenqsirafn sehkipyvrl erlkicaass gempvfklkp qkndqdgsfl liiecgtess
     1081 smsikrppev egtspeehrl iprtpgakkg ppapienedf cavclnggel lccdrcpkvf
     1141 hlschvpall sfpggewvct lcrsltqpem eydcenacyn qpgmraspgl smydqkkcek
     1201 lvlslccnnl slpfhepvsp larhyyqiik rpmdlsiirr klqkkdpahy ttpeevvsdv
     1261 rlmfwncakf nypdsevaea grclevffeg wlkeiypekr faqprqedsd seevssesgc
     1321 stpqgfpwpp ymqegiqpkr rrrhmenera krmsfrlans isqv
//
LOCUS       XP_054226629            1364 aa            linear   PRI 05-AUG-2025
DEFINITION  tripartite motif-containing protein 66 isoform X4 [Homo sapiens].
ACCESSION   XP_054226629
VERSION     XP_054226629.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370654.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1364
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1364
                     /product="tripartite motif-containing protein 66 isoform
                     X4"
                     /calculated_mol_wt=150838
     Region          149..185
                     /region_name="Bbox1_TRIM66"
                     /note="B-box-type 1 zinc finger found in tripartite
                     motif-containing protein 66 (TRIM66) and similar proteins;
                     cd19811"
                     /db_xref="CDD:380869"
     Region          208..250
                     /region_name="Bbox2_TRIM66-like"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing protein 66 (TRIM66) and similar proteins;
                     cd19794"
                     /db_xref="CDD:380852"
     Region          253..378
                     /region_name="BBC"
                     /note="B-Box C-terminal domain; smart00502"
                     /db_xref="CDD:128778"
     Region          710..909
                     /region_name="rad23"
                     /note="UV excision repair protein Rad23; TIGR00601"
                     /db_xref="CDD:273167"
     Region          1117..1165
                     /region_name="PHD_SF"
                     /note="PHD finger superfamily; cl22851"
                     /db_xref="CDD:473978"
     Site            order(1120,1130..1133,1137,1157)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:276966"
     Region          1190..1298
                     /region_name="Bromo_tif1_like"
                     /note="Bromodomain; tif1_like subfamily. Tif1
                     (transcription intermediary factor 1) is a member of the
                     tripartite motif (TRIM) protein family, which is
                     characterized by a particular domain architecture. It
                     functions by recruiting coactivators and/or...; cd05502"
                     /db_xref="CDD:99934"
     Site            order(1218,1222,1225,1267,1271,1277)
                     /site_type="other"
                     /note="putative acetyllysine binding site [chemical
                     binding]"
                     /db_xref="CDD:99934"
     CDS             1..1364
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /coded_by="XM_054370654.1:649..4743"
                     /db_xref="GeneID:9866"
                     /db_xref="HGNC:HGNC:29005"
                     /db_xref="MIM:612000"
ORIGIN      
        1 marlsfwsqg velarstrcf spedisgkap vlgtgmavdm gmsfmglpla gqkhcpksgq
       61 meamvmtcsl chqdlpgmgs hllscqhllr kdcfqgliqe lgqiakahet vadeliscpg
      121 cervyltrdv tehfflhcvp teqpkmarnc seckekraah ilctycnrwl csscteehrh
      181 spvpggpffp raqkgspgvn ggpgdftlyc plhtqevlkl fcetcdmltc hsclvvehke
      241 hrcrhveevl qnqrmllegv ttqvahkkss lqtsakqied rifevkhqhr kvenqikmak
      301 mvlmnelnkq anglieeleg itnerkrkle qqlqsimvln rqfehvqnfi nwavcsktsv
      361 pflfskeliv fqmqrllets cntdpgspws irftwepnfw tkqlaslgci tteggqmsra
      421 dapaygglqg sspfyqshqs pvaqqealsh pshkfqspav csssvccsrc spvspslkgq
      481 vpppsihpah sfrqppemvp qqlgslqcsa llprekelac sphppkllqp wletqppveq
      541 estsqrlgqq ltsqpvcivp pqdvqqgaha qptlqtpsiq vqfghhqklk lshfqqqpqq
      601 qlpppppplp rpppplpppp qqphpplpps qhlassqhes ppgpacsqnm dimhhkfele
      661 emqkdlelll qaqqpslqls qtkspqhlqq tivgqinyiv rqpapvqsqs qeetlqatde
      721 ppasqgskpa lpldkntaaa lpqasgeetp lsvppvdsti qhsspnvvrk hstslsimgf
      781 sntlemelss trlerplepq iqsvsnltag apqavpslls appkmvsslt svqnqampsl
      841 ttshlqtvps lvhstfqsmp nlisdspqam aslasdhpqa gpslmsghtq avpslatcpl
      901 qsippvsdmq petgsssssg rtsgslcprd gadpslenal ckmesedstr ftdllgqgpi
      961 vpgldapkdl aipseleepi nlsvkkppla pvvststalq qyqnpkecen feqgalelda
     1021 kenqsirafn sehkipyvrl erlkicaass gempvfklkp qkndqdgsfl liiecgtess
     1081 smsikrppev egtspeehrl iprtpgakkg ppapienedf cavclnggel lccdrcpkvf
     1141 hlschvpall sfpggewvct lcrsltqpem eydcenacyn qpgmraspgl smydqkkcek
     1201 lvlslccnnl slpfhepvsp larhyyqiik rpmdlsiirr klqkkdpahy ttpeevvsdv
     1261 rlmfwncakf nypdsevaea grclevffeg wlkeiypekr faqprqedsd seevssesgc
     1321 stpqgfpwpp ymqegiqpkr rrrhmenera krmsfrlans isqv
//
LOCUS       XP_054226630            1364 aa            linear   PRI 05-AUG-2025
DEFINITION  tripartite motif-containing protein 66 isoform X4 [Homo sapiens].
ACCESSION   XP_054226630
VERSION     XP_054226630.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370655.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1364
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1364
                     /product="tripartite motif-containing protein 66 isoform
                     X4"
                     /calculated_mol_wt=150838
     Region          149..185
                     /region_name="Bbox1_TRIM66"
                     /note="B-box-type 1 zinc finger found in tripartite
                     motif-containing protein 66 (TRIM66) and similar proteins;
                     cd19811"
                     /db_xref="CDD:380869"
     Region          208..250
                     /region_name="Bbox2_TRIM66-like"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing protein 66 (TRIM66) and similar proteins;
                     cd19794"
                     /db_xref="CDD:380852"
     Region          253..378
                     /region_name="BBC"
                     /note="B-Box C-terminal domain; smart00502"
                     /db_xref="CDD:128778"
     Region          710..909
                     /region_name="rad23"
                     /note="UV excision repair protein Rad23; TIGR00601"
                     /db_xref="CDD:273167"
     Region          1117..1165
                     /region_name="PHD_SF"
                     /note="PHD finger superfamily; cl22851"
                     /db_xref="CDD:473978"
     Site            order(1120,1130..1133,1137,1157)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:276966"
     Region          1190..1298
                     /region_name="Bromo_tif1_like"
                     /note="Bromodomain; tif1_like subfamily. Tif1
                     (transcription intermediary factor 1) is a member of the
                     tripartite motif (TRIM) protein family, which is
                     characterized by a particular domain architecture. It
                     functions by recruiting coactivators and/or...; cd05502"
                     /db_xref="CDD:99934"
     Site            order(1218,1222,1225,1267,1271,1277)
                     /site_type="other"
                     /note="putative acetyllysine binding site [chemical
                     binding]"
                     /db_xref="CDD:99934"
     CDS             1..1364
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /coded_by="XM_054370655.1:546..4640"
                     /db_xref="GeneID:9866"
                     /db_xref="HGNC:HGNC:29005"
                     /db_xref="MIM:612000"
ORIGIN      
        1 marlsfwsqg velarstrcf spedisgkap vlgtgmavdm gmsfmglpla gqkhcpksgq
       61 meamvmtcsl chqdlpgmgs hllscqhllr kdcfqgliqe lgqiakahet vadeliscpg
      121 cervyltrdv tehfflhcvp teqpkmarnc seckekraah ilctycnrwl csscteehrh
      181 spvpggpffp raqkgspgvn ggpgdftlyc plhtqevlkl fcetcdmltc hsclvvehke
      241 hrcrhveevl qnqrmllegv ttqvahkkss lqtsakqied rifevkhqhr kvenqikmak
      301 mvlmnelnkq anglieeleg itnerkrkle qqlqsimvln rqfehvqnfi nwavcsktsv
      361 pflfskeliv fqmqrllets cntdpgspws irftwepnfw tkqlaslgci tteggqmsra
      421 dapaygglqg sspfyqshqs pvaqqealsh pshkfqspav csssvccsrc spvspslkgq
      481 vpppsihpah sfrqppemvp qqlgslqcsa llprekelac sphppkllqp wletqppveq
      541 estsqrlgqq ltsqpvcivp pqdvqqgaha qptlqtpsiq vqfghhqklk lshfqqqpqq
      601 qlpppppplp rpppplpppp qqphpplpps qhlassqhes ppgpacsqnm dimhhkfele
      661 emqkdlelll qaqqpslqls qtkspqhlqq tivgqinyiv rqpapvqsqs qeetlqatde
      721 ppasqgskpa lpldkntaaa lpqasgeetp lsvppvdsti qhsspnvvrk hstslsimgf
      781 sntlemelss trlerplepq iqsvsnltag apqavpslls appkmvsslt svqnqampsl
      841 ttshlqtvps lvhstfqsmp nlisdspqam aslasdhpqa gpslmsghtq avpslatcpl
      901 qsippvsdmq petgsssssg rtsgslcprd gadpslenal ckmesedstr ftdllgqgpi
      961 vpgldapkdl aipseleepi nlsvkkppla pvvststalq qyqnpkecen feqgalelda
     1021 kenqsirafn sehkipyvrl erlkicaass gempvfklkp qkndqdgsfl liiecgtess
     1081 smsikrppev egtspeehrl iprtpgakkg ppapienedf cavclnggel lccdrcpkvf
     1141 hlschvpall sfpggewvct lcrsltqpem eydcenacyn qpgmraspgl smydqkkcek
     1201 lvlslccnnl slpfhepvsp larhyyqiik rpmdlsiirr klqkkdpahy ttpeevvsdv
     1261 rlmfwncakf nypdsevaea grclevffeg wlkeiypekr faqprqedsd seevssesgc
     1321 stpqgfpwpp ymqegiqpkr rrrhmenera krmsfrlans isqv
//
LOCUS       XP_054226631            1355 aa            linear   PRI 05-AUG-2025
DEFINITION  tripartite motif-containing protein 66 isoform X5 [Homo sapiens].
ACCESSION   XP_054226631
VERSION     XP_054226631.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370656.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1355
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1355
                     /product="tripartite motif-containing protein 66 isoform
                     X5"
                     /calculated_mol_wt=149688
     Region          112..148
                     /region_name="Bbox1_TRIM66"
                     /note="B-box-type 1 zinc finger found in tripartite
                     motif-containing protein 66 (TRIM66) and similar proteins;
                     cd19811"
                     /db_xref="CDD:380869"
     Region          171..213
                     /region_name="Bbox2_TRIM66-like"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing protein 66 (TRIM66) and similar proteins;
                     cd19794"
                     /db_xref="CDD:380852"
     Region          216..341
                     /region_name="BBC"
                     /note="B-Box C-terminal domain; smart00502"
                     /db_xref="CDD:128778"
     Region          1108..1156
                     /region_name="PHD_SF"
                     /note="PHD finger superfamily; cl22851"
                     /db_xref="CDD:473978"
     Site            order(1111,1121..1124,1128,1148)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:276966"
     Region          1181..1289
                     /region_name="Bromo_tif1_like"
                     /note="Bromodomain; tif1_like subfamily. Tif1
                     (transcription intermediary factor 1) is a member of the
                     tripartite motif (TRIM) protein family, which is
                     characterized by a particular domain architecture. It
                     functions by recruiting coactivators and/or...; cd05502"
                     /db_xref="CDD:99934"
     Site            order(1209,1213,1216,1258,1262,1268)
                     /site_type="other"
                     /note="putative acetyllysine binding site [chemical
                     binding]"
                     /db_xref="CDD:99934"
     CDS             1..1355
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /coded_by="XM_054370656.1:649..4716"
                     /db_xref="GeneID:9866"
                     /db_xref="HGNC:HGNC:29005"
                     /db_xref="MIM:612000"
ORIGIN      
        1 marlsfwsqg velarstrcf spedisgkap vlgtgmavdm gmsfmglpla gqkhcpksgq
       61 meamvmtcsl chqdlpelis cpgcervylt rdvtehfflh cvpteqpkma rncseckekr
      121 aahilctycn rwlcssctee hrhspvpggp ffpraqkgsp gvnggpgdft lycplhtqev
      181 lklfcetcdm ltchsclvve hkehrcrhve evlqnqrmll egvttqvahk ksslqtsakq
      241 iedrifevkh qhrkvenqik makmvlmnel nkqangliee legitnerkr kleqqlqsim
      301 vlnrqfehvq nfinwavcsk tsvpflfske livfqmqrll etscntdpgs pwsirftwep
      361 nfwtkqlasl gcitteggqm sradapaygg lqgsspfyqs hqspvaqqea lshpshkfqs
      421 pavcsssvcc srcspvspsl kgqvpppsih pahsfrqppe mvpqqlgslq csallpreke
      481 lacsphppkl lqpwletqpp veqestsqrl gqqltsqpvc ivppqdvqqg ahaqptlqtp
      541 siqvqfghhq klklshfqqq pqqqlppppp plprpppplp pppqqphppl ppsqhlassq
      601 hesppgpacs qnmdimhhkf eleemqkdle lllqaqqpsl qlsqtkspqh lqqtivgqin
      661 yivrqpapvq sqsqeetlqa tdeppasqgs kpalpldknt aaalpqasge etplsvppvd
      721 stiqhsspnv vrkhstslsi mgfsntleme lsstrlerpl epqiqsvsnl tagapqavps
      781 llsappkmvs sltsvqnqam pslttshlqt vpslvhstfq smpnlisdsp qamaslasdh
      841 pqagpslmsg htqavpslat cplqsippvs dmqpetgsss ssgrtsgslc prdgadpsle
      901 nalckmesed strftdllgq gpivpgldap kdlaipsele epinlsvkkp plapvvstst
      961 alqqyqnpke cenfeqgale ldakenqsir afnsehkipy vrlerlkica assgempvfk
     1021 lkpqkndqdg sflliiecgt esssmsikvs qdrlseatqa pglegrkvtv tslagqrppe
     1081 vegtspeehr liprtpgakk gppapiened fcavclngge llccdrcpkv fhlschvpal
     1141 lsfpggewvc tlcrsltqpe meydcenacy nqpgmraspg lsmydqkkce klvlslccnn
     1201 lslpfhepvs plarhyyqii krpmdlsiir rklqkkdpah yttpeevvsd vrlmfwncak
     1261 fnypdsevae agrclevffe gwlkeiypek rfaqprqeds dseevssesg cstpqgfpwp
     1321 pymqegiqpk rrrrhmener akrmsfrlan sisqv
//
LOCUS       XP_054226632            1327 aa            linear   PRI 05-AUG-2025
DEFINITION  tripartite motif-containing protein 66 isoform X6 [Homo sapiens].
ACCESSION   XP_054226632
VERSION     XP_054226632.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370657.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1327
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1327
                     /product="tripartite motif-containing protein 66 isoform
                     X6"
                     /calculated_mol_wt=146807
     Region          112..148
                     /region_name="Bbox1_TRIM66"
                     /note="B-box-type 1 zinc finger found in tripartite
                     motif-containing protein 66 (TRIM66) and similar proteins;
                     cd19811"
                     /db_xref="CDD:380869"
     Region          171..213
                     /region_name="Bbox2_TRIM66-like"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing protein 66 (TRIM66) and similar proteins;
                     cd19794"
                     /db_xref="CDD:380852"
     Region          216..341
                     /region_name="BBC"
                     /note="B-Box C-terminal domain; smart00502"
                     /db_xref="CDD:128778"
     Region          1080..1128
                     /region_name="PHD_SF"
                     /note="PHD finger superfamily; cl22851"
                     /db_xref="CDD:473978"
     Site            order(1083,1093..1096,1100,1120)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:276966"
     Region          1153..1261
                     /region_name="Bromo_tif1_like"
                     /note="Bromodomain; tif1_like subfamily. Tif1
                     (transcription intermediary factor 1) is a member of the
                     tripartite motif (TRIM) protein family, which is
                     characterized by a particular domain architecture. It
                     functions by recruiting coactivators and/or...; cd05502"
                     /db_xref="CDD:99934"
     Site            order(1181,1185,1188,1230,1234,1240)
                     /site_type="other"
                     /note="putative acetyllysine binding site [chemical
                     binding]"
                     /db_xref="CDD:99934"
     CDS             1..1327
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /coded_by="XM_054370657.1:613..4596"
                     /db_xref="GeneID:9866"
                     /db_xref="HGNC:HGNC:29005"
                     /db_xref="MIM:612000"
ORIGIN      
        1 marlsfwsqg velarstrcf spedisgkap vlgtgmavdm gmsfmglpla gqkhcpksgq
       61 meamvmtcsl chqdlpelis cpgcervylt rdvtehfflh cvpteqpkma rncseckekr
      121 aahilctycn rwlcssctee hrhspvpggp ffpraqkgsp gvnggpgdft lycplhtqev
      181 lklfcetcdm ltchsclvve hkehrcrhve evlqnqrmll egvttqvahk ksslqtsakq
      241 iedrifevkh qhrkvenqik makmvlmnel nkqangliee legitnerkr kleqqlqsim
      301 vlnrqfehvq nfinwavcsk tsvpflfske livfqmqrll etscntdpgs pwsirftwep
      361 nfwtkqlasl gcitteggqm sradapaygg lqgsspfyqs hqspvaqqea lshpshkfqs
      421 pavcsssvcc srcspvspsl kgqvpppsih pahsfrqppe mvpqqlgslq csallpreke
      481 lacsphppkl lqpwletqpp veqestsqrl gqqltsqpvc ivppqdvqqg ahaqptlqtp
      541 siqvqfghhq klklshfqqq pqqqlppppp plprpppplp pppqqphppl ppsqhlassq
      601 hesppgpacs qnmdimhhkf eleemqkdle lllqaqqpsl qlsqtkspqh lqqtivgqin
      661 yivrqpapvq sqsqeetlqa tdeppasqgs kpalpldknt aaalpqasge etplsvppvd
      721 stiqhsspnv vrkhstslsi mgfsntleme lsstrlerpl epqiqsvsnl tagapqavps
      781 llsappkmvs sltsvqnqam pslttshlqt vpslvhstfq smpnlisdsp qamaslasdh
      841 pqagpslmsg htqavpslat cplqsippvs dmqpetgsss ssgrtsgslc prdgadpsle
      901 nalckmesed strftdllgq gpivpgldap kdlaipsele epinlsvkkp plapvvstst
      961 alqqyqnpke cenfeqgale ldakenqsir afnsehkipy vrlerlkica assgempvfk
     1021 lkpqkndqdg sflliiecgt esssmsikrp pevegtspee hrliprtpga kkgppapien
     1081 edfcavclng gellccdrcp kvfhlschvp allsfpggew vctlcrsltq pemeydcena
     1141 cynqpgmras pglsmydqkk ceklvlslcc nnlslpfhep vsplarhyyq iikrpmdlsi
     1201 irrklqkkdp ahyttpeevv sdvrlmfwnc akfnypdsev aeagrclevf fegwlkeiyp
     1261 ekrfaqprqe dsdseevsse sgcstpqgfp wppymqegiq pkrrrrhmen erakrmsfrl
     1321 ansisqv
//
LOCUS       XP_054226633            1327 aa            linear   PRI 05-AUG-2025
DEFINITION  tripartite motif-containing protein 66 isoform X6 [Homo sapiens].
ACCESSION   XP_054226633
VERSION     XP_054226633.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370658.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1327
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1327
                     /product="tripartite motif-containing protein 66 isoform
                     X6"
                     /calculated_mol_wt=146807
     Region          112..148
                     /region_name="Bbox1_TRIM66"
                     /note="B-box-type 1 zinc finger found in tripartite
                     motif-containing protein 66 (TRIM66) and similar proteins;
                     cd19811"
                     /db_xref="CDD:380869"
     Region          171..213
                     /region_name="Bbox2_TRIM66-like"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing protein 66 (TRIM66) and similar proteins;
                     cd19794"
                     /db_xref="CDD:380852"
     Region          216..341
                     /region_name="BBC"
                     /note="B-Box C-terminal domain; smart00502"
                     /db_xref="CDD:128778"
     Region          1080..1128
                     /region_name="PHD_SF"
                     /note="PHD finger superfamily; cl22851"
                     /db_xref="CDD:473978"
     Site            order(1083,1093..1096,1100,1120)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:276966"
     Region          1153..1261
                     /region_name="Bromo_tif1_like"
                     /note="Bromodomain; tif1_like subfamily. Tif1
                     (transcription intermediary factor 1) is a member of the
                     tripartite motif (TRIM) protein family, which is
                     characterized by a particular domain architecture. It
                     functions by recruiting coactivators and/or...; cd05502"
                     /db_xref="CDD:99934"
     Site            order(1181,1185,1188,1230,1234,1240)
                     /site_type="other"
                     /note="putative acetyllysine binding site [chemical
                     binding]"
                     /db_xref="CDD:99934"
     CDS             1..1327
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /coded_by="XM_054370658.1:649..4632"
                     /db_xref="GeneID:9866"
                     /db_xref="HGNC:HGNC:29005"
                     /db_xref="MIM:612000"
ORIGIN      
        1 marlsfwsqg velarstrcf spedisgkap vlgtgmavdm gmsfmglpla gqkhcpksgq
       61 meamvmtcsl chqdlpelis cpgcervylt rdvtehfflh cvpteqpkma rncseckekr
      121 aahilctycn rwlcssctee hrhspvpggp ffpraqkgsp gvnggpgdft lycplhtqev
      181 lklfcetcdm ltchsclvve hkehrcrhve evlqnqrmll egvttqvahk ksslqtsakq
      241 iedrifevkh qhrkvenqik makmvlmnel nkqangliee legitnerkr kleqqlqsim
      301 vlnrqfehvq nfinwavcsk tsvpflfske livfqmqrll etscntdpgs pwsirftwep
      361 nfwtkqlasl gcitteggqm sradapaygg lqgsspfyqs hqspvaqqea lshpshkfqs
      421 pavcsssvcc srcspvspsl kgqvpppsih pahsfrqppe mvpqqlgslq csallpreke
      481 lacsphppkl lqpwletqpp veqestsqrl gqqltsqpvc ivppqdvqqg ahaqptlqtp
      541 siqvqfghhq klklshfqqq pqqqlppppp plprpppplp pppqqphppl ppsqhlassq
      601 hesppgpacs qnmdimhhkf eleemqkdle lllqaqqpsl qlsqtkspqh lqqtivgqin
      661 yivrqpapvq sqsqeetlqa tdeppasqgs kpalpldknt aaalpqasge etplsvppvd
      721 stiqhsspnv vrkhstslsi mgfsntleme lsstrlerpl epqiqsvsnl tagapqavps
      781 llsappkmvs sltsvqnqam pslttshlqt vpslvhstfq smpnlisdsp qamaslasdh
      841 pqagpslmsg htqavpslat cplqsippvs dmqpetgsss ssgrtsgslc prdgadpsle
      901 nalckmesed strftdllgq gpivpgldap kdlaipsele epinlsvkkp plapvvstst
      961 alqqyqnpke cenfeqgale ldakenqsir afnsehkipy vrlerlkica assgempvfk
     1021 lkpqkndqdg sflliiecgt esssmsikrp pevegtspee hrliprtpga kkgppapien
     1081 edfcavclng gellccdrcp kvfhlschvp allsfpggew vctlcrsltq pemeydcena
     1141 cynqpgmras pglsmydqkk ceklvlslcc nnlslpfhep vsplarhyyq iikrpmdlsi
     1201 irrklqkkdp ahyttpeevv sdvrlmfwnc akfnypdsev aeagrclevf fegwlkeiyp
     1261 ekrfaqprqe dsdseevsse sgcstpqgfp wppymqegiq pkrrrrhmen erakrmsfrl
     1321 ansisqv
//
LOCUS       XP_054226634            1306 aa            linear   PRI 05-AUG-2025
DEFINITION  tripartite motif-containing protein 66 isoform X7 [Homo sapiens].
ACCESSION   XP_054226634
VERSION     XP_054226634.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370659.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1306
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1306
                     /product="tripartite motif-containing protein 66 isoform
                     X7"
                     /calculated_mol_wt=144487
     Region          63..99
                     /region_name="Bbox1_TRIM66"
                     /note="B-box-type 1 zinc finger found in tripartite
                     motif-containing protein 66 (TRIM66) and similar proteins;
                     cd19811"
                     /db_xref="CDD:380869"
     Region          122..164
                     /region_name="Bbox2_TRIM66-like"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing protein 66 (TRIM66) and similar proteins;
                     cd19794"
                     /db_xref="CDD:380852"
     Region          167..292
                     /region_name="BBC"
                     /note="B-Box C-terminal domain; smart00502"
                     /db_xref="CDD:128778"
     Region          1059..1107
                     /region_name="PHD_SF"
                     /note="PHD finger superfamily; cl22851"
                     /db_xref="CDD:473978"
     Site            order(1062,1072..1075,1079,1099)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:276966"
     Region          1132..1240
                     /region_name="Bromo_tif1_like"
                     /note="Bromodomain; tif1_like subfamily. Tif1
                     (transcription intermediary factor 1) is a member of the
                     tripartite motif (TRIM) protein family, which is
                     characterized by a particular domain architecture. It
                     functions by recruiting coactivators and/or...; cd05502"
                     /db_xref="CDD:99934"
     Site            order(1160,1164,1167,1209,1213,1219)
                     /site_type="other"
                     /note="putative acetyllysine binding site [chemical
                     binding]"
                     /db_xref="CDD:99934"
     CDS             1..1306
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /coded_by="XM_054370659.1:2110..6030"
                     /db_xref="GeneID:9866"
                     /db_xref="HGNC:HGNC:29005"
                     /db_xref="MIM:612000"
ORIGIN      
        1 mglrhlsgte etswarsska ndgdqskeli scpgcervyl trdvtehffl hcvpteqpkm
       61 arncseckek raahilctyc nrwlcsscte ehrhspvpgg pffpraqkgs pgvnggpgdf
      121 tlycplhtqe vlklfcetcd mltchsclvv ehkehrcrhv eevlqnqrml legvttqvah
      181 kksslqtsak qiedrifevk hqhrkvenqi kmakmvlmne lnkqanglie elegitnerk
      241 rkleqqlqsi mvlnrqfehv qnfinwavcs ktsvpflfsk elivfqmqrl letscntdpg
      301 spwsirftwe pnfwtkqlas lgcitteggq msradapayg glqgsspfyq shqspvaqqe
      361 alshpshkfq spavcsssvc csrcspvsps lkgqvpppsi hpahsfrqpp emvpqqlgsl
      421 qcsallprek elacsphppk llqpwletqp pveqestsqr lgqqltsqpv civppqdvqq
      481 gahaqptlqt psiqvqfghh qklklshfqq qpqqqlpppp pplprppppl ppppqqphpp
      541 lppsqhlass qhesppgpac sqnmdimhhk feleemqkdl elllqaqqps lqlsqtkspq
      601 hlqqtivgqi nyivrqpapv qsqsqeetlq atdeppasqg skpalpldkn taaalpqasg
      661 eetplsvppv dstiqhsspn vvrkhstsls imgfsntlem elsstrlerp lepqiqsvsn
      721 ltagapqavp sllsappkmv ssltsvqnqa mpslttshlq tvpslvhstf qsmpnlisds
      781 pqamaslasd hpqagpslms ghtqavpsla tcplqsippv sdmqpetgss sssgrtsgsl
      841 cprdgadpsl enalckmese dstrftdllg qgpivpglda pkdlaipsel eepinlsvkk
      901 pplapvvsts talqqyqnpk ecenfeqgal eldakenqsi rafnsehkip yvrlerlkic
      961 aassgempvf klkpqkndqd gsflliiecg tesssmsikv sqdrlseatq apglegrkvt
     1021 vtslagqrpp evegtspeeh rliprtpgak kgppapiene dfcavclngg ellccdrcpk
     1081 vfhlschvpa llsfpggewv ctlcrsltqp emeydcenac ynqpgmrasp glsmydqkkc
     1141 eklvlslccn nlslpfhepv splarhyyqi ikrpmdlsii rrklqkkdpa hyttpeevvs
     1201 dvrlmfwnca kfnypdseva eagrclevff egwlkeiype krfaqprqed sdseevsses
     1261 gcstpqgfpw ppymqegiqp krrrrhmene rakrmsfrla nsisqv
//
LOCUS       XP_054226635            1306 aa            linear   PRI 05-AUG-2025
DEFINITION  tripartite motif-containing protein 66 isoform X7 [Homo sapiens].
ACCESSION   XP_054226635
VERSION     XP_054226635.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370660.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1306
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1306
                     /product="tripartite motif-containing protein 66 isoform
                     X7"
                     /calculated_mol_wt=144487
     Region          63..99
                     /region_name="Bbox1_TRIM66"
                     /note="B-box-type 1 zinc finger found in tripartite
                     motif-containing protein 66 (TRIM66) and similar proteins;
                     cd19811"
                     /db_xref="CDD:380869"
     Region          122..164
                     /region_name="Bbox2_TRIM66-like"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing protein 66 (TRIM66) and similar proteins;
                     cd19794"
                     /db_xref="CDD:380852"
     Region          167..292
                     /region_name="BBC"
                     /note="B-Box C-terminal domain; smart00502"
                     /db_xref="CDD:128778"
     Region          1059..1107
                     /region_name="PHD_SF"
                     /note="PHD finger superfamily; cl22851"
                     /db_xref="CDD:473978"
     Site            order(1062,1072..1075,1079,1099)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:276966"
     Region          1132..1240
                     /region_name="Bromo_tif1_like"
                     /note="Bromodomain; tif1_like subfamily. Tif1
                     (transcription intermediary factor 1) is a member of the
                     tripartite motif (TRIM) protein family, which is
                     characterized by a particular domain architecture. It
                     functions by recruiting coactivators and/or...; cd05502"
                     /db_xref="CDD:99934"
     Site            order(1160,1164,1167,1209,1213,1219)
                     /site_type="other"
                     /note="putative acetyllysine binding site [chemical
                     binding]"
                     /db_xref="CDD:99934"
     CDS             1..1306
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /coded_by="XM_054370660.1:128..4048"
                     /db_xref="GeneID:9866"
                     /db_xref="HGNC:HGNC:29005"
                     /db_xref="MIM:612000"
ORIGIN      
        1 mglrhlsgte etswarsska ndgdqskeli scpgcervyl trdvtehffl hcvpteqpkm
       61 arncseckek raahilctyc nrwlcsscte ehrhspvpgg pffpraqkgs pgvnggpgdf
      121 tlycplhtqe vlklfcetcd mltchsclvv ehkehrcrhv eevlqnqrml legvttqvah
      181 kksslqtsak qiedrifevk hqhrkvenqi kmakmvlmne lnkqanglie elegitnerk
      241 rkleqqlqsi mvlnrqfehv qnfinwavcs ktsvpflfsk elivfqmqrl letscntdpg
      301 spwsirftwe pnfwtkqlas lgcitteggq msradapayg glqgsspfyq shqspvaqqe
      361 alshpshkfq spavcsssvc csrcspvsps lkgqvpppsi hpahsfrqpp emvpqqlgsl
      421 qcsallprek elacsphppk llqpwletqp pveqestsqr lgqqltsqpv civppqdvqq
      481 gahaqptlqt psiqvqfghh qklklshfqq qpqqqlpppp pplprppppl ppppqqphpp
      541 lppsqhlass qhesppgpac sqnmdimhhk feleemqkdl elllqaqqps lqlsqtkspq
      601 hlqqtivgqi nyivrqpapv qsqsqeetlq atdeppasqg skpalpldkn taaalpqasg
      661 eetplsvppv dstiqhsspn vvrkhstsls imgfsntlem elsstrlerp lepqiqsvsn
      721 ltagapqavp sllsappkmv ssltsvqnqa mpslttshlq tvpslvhstf qsmpnlisds
      781 pqamaslasd hpqagpslms ghtqavpsla tcplqsippv sdmqpetgss sssgrtsgsl
      841 cprdgadpsl enalckmese dstrftdllg qgpivpglda pkdlaipsel eepinlsvkk
      901 pplapvvsts talqqyqnpk ecenfeqgal eldakenqsi rafnsehkip yvrlerlkic
      961 aassgempvf klkpqkndqd gsflliiecg tesssmsikv sqdrlseatq apglegrkvt
     1021 vtslagqrpp evegtspeeh rliprtpgak kgppapiene dfcavclngg ellccdrcpk
     1081 vfhlschvpa llsfpggewv ctlcrsltqp emeydcenac ynqpgmrasp glsmydqkkc
     1141 eklvlslccn nlslpfhepv splarhyyqi ikrpmdlsii rrklqkkdpa hyttpeevvs
     1201 dvrlmfwnca kfnypdseva eagrclevff egwlkeiype krfaqprqed sdseevsses
     1261 gcstpqgfpw ppymqegiqp krrrrhmene rakrmsfrla nsisqv
//
LOCUS       XP_054226636            1306 aa            linear   PRI 05-AUG-2025
DEFINITION  tripartite motif-containing protein 66 isoform X7 [Homo sapiens].
ACCESSION   XP_054226636
VERSION     XP_054226636.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370661.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1306
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1306
                     /product="tripartite motif-containing protein 66 isoform
                     X7"
                     /calculated_mol_wt=144487
     Region          63..99
                     /region_name="Bbox1_TRIM66"
                     /note="B-box-type 1 zinc finger found in tripartite
                     motif-containing protein 66 (TRIM66) and similar proteins;
                     cd19811"
                     /db_xref="CDD:380869"
     Region          122..164
                     /region_name="Bbox2_TRIM66-like"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing protein 66 (TRIM66) and similar proteins;
                     cd19794"
                     /db_xref="CDD:380852"
     Region          167..292
                     /region_name="BBC"
                     /note="B-Box C-terminal domain; smart00502"
                     /db_xref="CDD:128778"
     Region          1059..1107
                     /region_name="PHD_SF"
                     /note="PHD finger superfamily; cl22851"
                     /db_xref="CDD:473978"
     Site            order(1062,1072..1075,1079,1099)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:276966"
     Region          1132..1240
                     /region_name="Bromo_tif1_like"
                     /note="Bromodomain; tif1_like subfamily. Tif1
                     (transcription intermediary factor 1) is a member of the
                     tripartite motif (TRIM) protein family, which is
                     characterized by a particular domain architecture. It
                     functions by recruiting coactivators and/or...; cd05502"
                     /db_xref="CDD:99934"
     Site            order(1160,1164,1167,1209,1213,1219)
                     /site_type="other"
                     /note="putative acetyllysine binding site [chemical
                     binding]"
                     /db_xref="CDD:99934"
     CDS             1..1306
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /coded_by="XM_054370661.1:126..4046"
                     /db_xref="GeneID:9866"
                     /db_xref="HGNC:HGNC:29005"
                     /db_xref="MIM:612000"
ORIGIN      
        1 mglrhlsgte etswarsska ndgdqskeli scpgcervyl trdvtehffl hcvpteqpkm
       61 arncseckek raahilctyc nrwlcsscte ehrhspvpgg pffpraqkgs pgvnggpgdf
      121 tlycplhtqe vlklfcetcd mltchsclvv ehkehrcrhv eevlqnqrml legvttqvah
      181 kksslqtsak qiedrifevk hqhrkvenqi kmakmvlmne lnkqanglie elegitnerk
      241 rkleqqlqsi mvlnrqfehv qnfinwavcs ktsvpflfsk elivfqmqrl letscntdpg
      301 spwsirftwe pnfwtkqlas lgcitteggq msradapayg glqgsspfyq shqspvaqqe
      361 alshpshkfq spavcsssvc csrcspvsps lkgqvpppsi hpahsfrqpp emvpqqlgsl
      421 qcsallprek elacsphppk llqpwletqp pveqestsqr lgqqltsqpv civppqdvqq
      481 gahaqptlqt psiqvqfghh qklklshfqq qpqqqlpppp pplprppppl ppppqqphpp
      541 lppsqhlass qhesppgpac sqnmdimhhk feleemqkdl elllqaqqps lqlsqtkspq
      601 hlqqtivgqi nyivrqpapv qsqsqeetlq atdeppasqg skpalpldkn taaalpqasg
      661 eetplsvppv dstiqhsspn vvrkhstsls imgfsntlem elsstrlerp lepqiqsvsn
      721 ltagapqavp sllsappkmv ssltsvqnqa mpslttshlq tvpslvhstf qsmpnlisds
      781 pqamaslasd hpqagpslms ghtqavpsla tcplqsippv sdmqpetgss sssgrtsgsl
      841 cprdgadpsl enalckmese dstrftdllg qgpivpglda pkdlaipsel eepinlsvkk
      901 pplapvvsts talqqyqnpk ecenfeqgal eldakenqsi rafnsehkip yvrlerlkic
      961 aassgempvf klkpqkndqd gsflliiecg tesssmsikv sqdrlseatq apglegrkvt
     1021 vtslagqrpp evegtspeeh rliprtpgak kgppapiene dfcavclngg ellccdrcpk
     1081 vfhlschvpa llsfpggewv ctlcrsltqp emeydcenac ynqpgmrasp glsmydqkkc
     1141 eklvlslccn nlslpfhepv splarhyyqi ikrpmdlsii rrklqkkdpa hyttpeevvs
     1201 dvrlmfwnca kfnypdseva eagrclevff egwlkeiype krfaqprqed sdseevsses
     1261 gcstpqgfpw ppymqegiqp krrrrhmene rakrmsfrla nsisqv
//
LOCUS       XP_054226637            1278 aa            linear   PRI 05-AUG-2025
DEFINITION  tripartite motif-containing protein 66 isoform X8 [Homo sapiens].
ACCESSION   XP_054226637
VERSION     XP_054226637.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370662.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1278
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1278
                     /product="tripartite motif-containing protein 66 isoform
                     X8"
                     /calculated_mol_wt=141606
     Region          63..99
                     /region_name="Bbox1_TRIM66"
                     /note="B-box-type 1 zinc finger found in tripartite
                     motif-containing protein 66 (TRIM66) and similar proteins;
                     cd19811"
                     /db_xref="CDD:380869"
     Region          122..164
                     /region_name="Bbox2_TRIM66-like"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing protein 66 (TRIM66) and similar proteins;
                     cd19794"
                     /db_xref="CDD:380852"
     Region          167..292
                     /region_name="BBC"
                     /note="B-Box C-terminal domain; smart00502"
                     /db_xref="CDD:128778"
     Region          1031..1079
                     /region_name="PHD_SF"
                     /note="PHD finger superfamily; cl22851"
                     /db_xref="CDD:473978"
     Site            order(1034,1044..1047,1051,1071)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:276966"
     Region          1104..1212
                     /region_name="Bromo_tif1_like"
                     /note="Bromodomain; tif1_like subfamily. Tif1
                     (transcription intermediary factor 1) is a member of the
                     tripartite motif (TRIM) protein family, which is
                     characterized by a particular domain architecture. It
                     functions by recruiting coactivators and/or...; cd05502"
                     /db_xref="CDD:99934"
     Site            order(1132,1136,1139,1181,1185,1191)
                     /site_type="other"
                     /note="putative acetyllysine binding site [chemical
                     binding]"
                     /db_xref="CDD:99934"
     CDS             1..1278
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /coded_by="XM_054370662.1:2719..6555"
                     /db_xref="GeneID:9866"
                     /db_xref="HGNC:HGNC:29005"
                     /db_xref="MIM:612000"
ORIGIN      
        1 mglrhlsgte etswarsska ndgdqskeli scpgcervyl trdvtehffl hcvpteqpkm
       61 arncseckek raahilctyc nrwlcsscte ehrhspvpgg pffpraqkgs pgvnggpgdf
      121 tlycplhtqe vlklfcetcd mltchsclvv ehkehrcrhv eevlqnqrml legvttqvah
      181 kksslqtsak qiedrifevk hqhrkvenqi kmakmvlmne lnkqanglie elegitnerk
      241 rkleqqlqsi mvlnrqfehv qnfinwavcs ktsvpflfsk elivfqmqrl letscntdpg
      301 spwsirftwe pnfwtkqlas lgcitteggq msradapayg glqgsspfyq shqspvaqqe
      361 alshpshkfq spavcsssvc csrcspvsps lkgqvpppsi hpahsfrqpp emvpqqlgsl
      421 qcsallprek elacsphppk llqpwletqp pveqestsqr lgqqltsqpv civppqdvqq
      481 gahaqptlqt psiqvqfghh qklklshfqq qpqqqlpppp pplprppppl ppppqqphpp
      541 lppsqhlass qhesppgpac sqnmdimhhk feleemqkdl elllqaqqps lqlsqtkspq
      601 hlqqtivgqi nyivrqpapv qsqsqeetlq atdeppasqg skpalpldkn taaalpqasg
      661 eetplsvppv dstiqhsspn vvrkhstsls imgfsntlem elsstrlerp lepqiqsvsn
      721 ltagapqavp sllsappkmv ssltsvqnqa mpslttshlq tvpslvhstf qsmpnlisds
      781 pqamaslasd hpqagpslms ghtqavpsla tcplqsippv sdmqpetgss sssgrtsgsl
      841 cprdgadpsl enalckmese dstrftdllg qgpivpglda pkdlaipsel eepinlsvkk
      901 pplapvvsts talqqyqnpk ecenfeqgal eldakenqsi rafnsehkip yvrlerlkic
      961 aassgempvf klkpqkndqd gsflliiecg tesssmsikr ppevegtspe ehrliprtpg
     1021 akkgppapie nedfcavcln ggellccdrc pkvfhlschv pallsfpgge wvctlcrslt
     1081 qpemeydcen acynqpgmra spglsmydqk kceklvlslc cnnlslpfhe pvsplarhyy
     1141 qiikrpmdls iirrklqkkd pahyttpeev vsdvrlmfwn cakfnypdse vaeagrclev
     1201 ffegwlkeiy pekrfaqprq edsdseevss esgcstpqgf pwppymqegi qpkrrrrhme
     1261 nerakrmsfr lansisqv
//
LOCUS       XP_054226638            1247 aa            linear   PRI 05-AUG-2025
DEFINITION  tripartite motif-containing protein 66 isoform X9 [Homo sapiens].
ACCESSION   XP_054226638
VERSION     XP_054226638.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370663.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1247
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1247
                     /product="tripartite motif-containing protein 66 isoform
                     X9"
                     /calculated_mol_wt=137825
     Region          4..40
                     /region_name="Bbox1_TRIM66"
                     /note="B-box-type 1 zinc finger found in tripartite
                     motif-containing protein 66 (TRIM66) and similar proteins;
                     cd19811"
                     /db_xref="CDD:380869"
     Region          63..105
                     /region_name="Bbox2_TRIM66-like"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing protein 66 (TRIM66) and similar proteins;
                     cd19794"
                     /db_xref="CDD:380852"
     Region          108..233
                     /region_name="BBC"
                     /note="B-Box C-terminal domain; smart00502"
                     /db_xref="CDD:128778"
     Region          1000..1048
                     /region_name="PHD_SF"
                     /note="PHD finger superfamily; cl22851"
                     /db_xref="CDD:473978"
     Site            order(1003,1013..1016,1020,1040)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:276966"
     Region          1073..1181
                     /region_name="Bromo_tif1_like"
                     /note="Bromodomain; tif1_like subfamily. Tif1
                     (transcription intermediary factor 1) is a member of the
                     tripartite motif (TRIM) protein family, which is
                     characterized by a particular domain architecture. It
                     functions by recruiting coactivators and/or...; cd05502"
                     /db_xref="CDD:99934"
     Site            order(1101,1105,1108,1150,1154,1160)
                     /site_type="other"
                     /note="putative acetyllysine binding site [chemical
                     binding]"
                     /db_xref="CDD:99934"
     CDS             1..1247
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /coded_by="XM_054370663.1:472..4215"
                     /db_xref="GeneID:9866"
                     /db_xref="HGNC:HGNC:29005"
                     /db_xref="MIM:612000"
ORIGIN      
        1 marncsecke kraahilcty cnrwlcssct eehrhspvpg gpffpraqkg spgvnggpgd
       61 ftlycplhtq evlklfcetc dmltchsclv vehkehrcrh veevlqnqrm llegvttqva
      121 hkksslqtsa kqiedrifev khqhrkvenq ikmakmvlmn elnkqangli eelegitner
      181 krkleqqlqs imvlnrqfeh vqnfinwavc sktsvpflfs kelivfqmqr lletscntdp
      241 gspwsirftw epnfwtkqla slgcittegg qmsradapay gglqgsspfy qshqspvaqq
      301 ealshpshkf qspavcsssv ccsrcspvsp slkgqvppps ihpahsfrqp pemvpqqlgs
      361 lqcsallpre kelacsphpp kllqpwletq ppveqestsq rlgqqltsqp vcivppqdvq
      421 qgahaqptlq tpsiqvqfgh hqklklshfq qqpqqqlppp ppplprpppp lppppqqphp
      481 plppsqhlas sqhesppgpa csqnmdimhh kfeleemqkd lelllqaqqp slqlsqtksp
      541 qhlqqtivgq inyivrqpap vqsqsqeetl qatdeppasq gskpalpldk ntaaalpqas
      601 geetplsvpp vdstiqhssp nvvrkhstsl simgfsntle melsstrler plepqiqsvs
      661 nltagapqav psllsappkm vssltsvqnq ampslttshl qtvpslvhst fqsmpnlisd
      721 spqamaslas dhpqagpslm sghtqavpsl atcplqsipp vsdmqpetgs ssssgrtsgs
      781 lcprdgadps lenalckmes edstrftdll gqgpivpgld apkdlaipse leepinlsvk
      841 kpplapvvst stalqqyqnp kecenfeqga leldakenqs irafnsehki pyvrlerlki
      901 caassgempv fklkpqkndq dgsflliiec gtesssmsik vsqdrlseat qapglegrkv
      961 tvtslagqrp pevegtspee hrliprtpga kkgppapien edfcavclng gellccdrcp
     1021 kvfhlschvp allsfpggew vctlcrsltq pemeydcena cynqpgmras pglsmydqkk
     1081 ceklvlslcc nnlslpfhep vsplarhyyq iikrpmdlsi irrklqkkdp ahyttpeevv
     1141 sdvrlmfwnc akfnypdsev aeagrclevf fegwlkeiyp ekrfaqprqe dsdseevsse
     1201 sgcstpqgfp wppymqegiq pkrrrrhmen erakrmsfrl ansisqv
//
LOCUS       XP_054226639            1247 aa            linear   PRI 05-AUG-2025
DEFINITION  tripartite motif-containing protein 66 isoform X9 [Homo sapiens].
ACCESSION   XP_054226639
VERSION     XP_054226639.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370664.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1247
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1247
                     /product="tripartite motif-containing protein 66 isoform
                     X9"
                     /calculated_mol_wt=137825
     Region          4..40
                     /region_name="Bbox1_TRIM66"
                     /note="B-box-type 1 zinc finger found in tripartite
                     motif-containing protein 66 (TRIM66) and similar proteins;
                     cd19811"
                     /db_xref="CDD:380869"
     Region          63..105
                     /region_name="Bbox2_TRIM66-like"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing protein 66 (TRIM66) and similar proteins;
                     cd19794"
                     /db_xref="CDD:380852"
     Region          108..233
                     /region_name="BBC"
                     /note="B-Box C-terminal domain; smart00502"
                     /db_xref="CDD:128778"
     Region          1000..1048
                     /region_name="PHD_SF"
                     /note="PHD finger superfamily; cl22851"
                     /db_xref="CDD:473978"
     Site            order(1003,1013..1016,1020,1040)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:276966"
     Region          1073..1181
                     /region_name="Bromo_tif1_like"
                     /note="Bromodomain; tif1_like subfamily. Tif1
                     (transcription intermediary factor 1) is a member of the
                     tripartite motif (TRIM) protein family, which is
                     characterized by a particular domain architecture. It
                     functions by recruiting coactivators and/or...; cd05502"
                     /db_xref="CDD:99934"
     Site            order(1101,1105,1108,1150,1154,1160)
                     /site_type="other"
                     /note="putative acetyllysine binding site [chemical
                     binding]"
                     /db_xref="CDD:99934"
     CDS             1..1247
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /coded_by="XM_054370664.1:472..4215"
                     /db_xref="GeneID:9866"
                     /db_xref="HGNC:HGNC:29005"
                     /db_xref="MIM:612000"
ORIGIN      
        1 marncsecke kraahilcty cnrwlcssct eehrhspvpg gpffpraqkg spgvnggpgd
       61 ftlycplhtq evlklfcetc dmltchsclv vehkehrcrh veevlqnqrm llegvttqva
      121 hkksslqtsa kqiedrifev khqhrkvenq ikmakmvlmn elnkqangli eelegitner
      181 krkleqqlqs imvlnrqfeh vqnfinwavc sktsvpflfs kelivfqmqr lletscntdp
      241 gspwsirftw epnfwtkqla slgcittegg qmsradapay gglqgsspfy qshqspvaqq
      301 ealshpshkf qspavcsssv ccsrcspvsp slkgqvppps ihpahsfrqp pemvpqqlgs
      361 lqcsallpre kelacsphpp kllqpwletq ppveqestsq rlgqqltsqp vcivppqdvq
      421 qgahaqptlq tpsiqvqfgh hqklklshfq qqpqqqlppp ppplprpppp lppppqqphp
      481 plppsqhlas sqhesppgpa csqnmdimhh kfeleemqkd lelllqaqqp slqlsqtksp
      541 qhlqqtivgq inyivrqpap vqsqsqeetl qatdeppasq gskpalpldk ntaaalpqas
      601 geetplsvpp vdstiqhssp nvvrkhstsl simgfsntle melsstrler plepqiqsvs
      661 nltagapqav psllsappkm vssltsvqnq ampslttshl qtvpslvhst fqsmpnlisd
      721 spqamaslas dhpqagpslm sghtqavpsl atcplqsipp vsdmqpetgs ssssgrtsgs
      781 lcprdgadps lenalckmes edstrftdll gqgpivpgld apkdlaipse leepinlsvk
      841 kpplapvvst stalqqyqnp kecenfeqga leldakenqs irafnsehki pyvrlerlki
      901 caassgempv fklkpqkndq dgsflliiec gtesssmsik vsqdrlseat qapglegrkv
      961 tvtslagqrp pevegtspee hrliprtpga kkgppapien edfcavclng gellccdrcp
     1021 kvfhlschvp allsfpggew vctlcrsltq pemeydcena cynqpgmras pglsmydqkk
     1081 ceklvlslcc nnlslpfhep vsplarhyyq iikrpmdlsi irrklqkkdp ahyttpeevv
     1141 sdvrlmfwnc akfnypdsev aeagrclevf fegwlkeiyp ekrfaqprqe dsdseevsse
     1201 sgcstpqgfp wppymqegiq pkrrrrhmen erakrmsfrl ansisqv
//
LOCUS       XP_054226640            1247 aa            linear   PRI 05-AUG-2025
DEFINITION  tripartite motif-containing protein 66 isoform X9 [Homo sapiens].
ACCESSION   XP_054226640
VERSION     XP_054226640.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370665.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1247
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1247
                     /product="tripartite motif-containing protein 66 isoform
                     X9"
                     /calculated_mol_wt=137825
     Region          4..40
                     /region_name="Bbox1_TRIM66"
                     /note="B-box-type 1 zinc finger found in tripartite
                     motif-containing protein 66 (TRIM66) and similar proteins;
                     cd19811"
                     /db_xref="CDD:380869"
     Region          63..105
                     /region_name="Bbox2_TRIM66-like"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing protein 66 (TRIM66) and similar proteins;
                     cd19794"
                     /db_xref="CDD:380852"
     Region          108..233
                     /region_name="BBC"
                     /note="B-Box C-terminal domain; smart00502"
                     /db_xref="CDD:128778"
     Region          1000..1048
                     /region_name="PHD_SF"
                     /note="PHD finger superfamily; cl22851"
                     /db_xref="CDD:473978"
     Site            order(1003,1013..1016,1020,1040)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:276966"
     Region          1073..1181
                     /region_name="Bromo_tif1_like"
                     /note="Bromodomain; tif1_like subfamily. Tif1
                     (transcription intermediary factor 1) is a member of the
                     tripartite motif (TRIM) protein family, which is
                     characterized by a particular domain architecture. It
                     functions by recruiting coactivators and/or...; cd05502"
                     /db_xref="CDD:99934"
     Site            order(1101,1105,1108,1150,1154,1160)
                     /site_type="other"
                     /note="putative acetyllysine binding site [chemical
                     binding]"
                     /db_xref="CDD:99934"
     CDS             1..1247
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /coded_by="XM_054370665.1:2158..5901"
                     /db_xref="GeneID:9866"
                     /db_xref="HGNC:HGNC:29005"
                     /db_xref="MIM:612000"
ORIGIN      
        1 marncsecke kraahilcty cnrwlcssct eehrhspvpg gpffpraqkg spgvnggpgd
       61 ftlycplhtq evlklfcetc dmltchsclv vehkehrcrh veevlqnqrm llegvttqva
      121 hkksslqtsa kqiedrifev khqhrkvenq ikmakmvlmn elnkqangli eelegitner
      181 krkleqqlqs imvlnrqfeh vqnfinwavc sktsvpflfs kelivfqmqr lletscntdp
      241 gspwsirftw epnfwtkqla slgcittegg qmsradapay gglqgsspfy qshqspvaqq
      301 ealshpshkf qspavcsssv ccsrcspvsp slkgqvppps ihpahsfrqp pemvpqqlgs
      361 lqcsallpre kelacsphpp kllqpwletq ppveqestsq rlgqqltsqp vcivppqdvq
      421 qgahaqptlq tpsiqvqfgh hqklklshfq qqpqqqlppp ppplprpppp lppppqqphp
      481 plppsqhlas sqhesppgpa csqnmdimhh kfeleemqkd lelllqaqqp slqlsqtksp
      541 qhlqqtivgq inyivrqpap vqsqsqeetl qatdeppasq gskpalpldk ntaaalpqas
      601 geetplsvpp vdstiqhssp nvvrkhstsl simgfsntle melsstrler plepqiqsvs
      661 nltagapqav psllsappkm vssltsvqnq ampslttshl qtvpslvhst fqsmpnlisd
      721 spqamaslas dhpqagpslm sghtqavpsl atcplqsipp vsdmqpetgs ssssgrtsgs
      781 lcprdgadps lenalckmes edstrftdll gqgpivpgld apkdlaipse leepinlsvk
      841 kpplapvvst stalqqyqnp kecenfeqga leldakenqs irafnsehki pyvrlerlki
      901 caassgempv fklkpqkndq dgsflliiec gtesssmsik vsqdrlseat qapglegrkv
      961 tvtslagqrp pevegtspee hrliprtpga kkgppapien edfcavclng gellccdrcp
     1021 kvfhlschvp allsfpggew vctlcrsltq pemeydcena cynqpgmras pglsmydqkk
     1081 ceklvlslcc nnlslpfhep vsplarhyyq iikrpmdlsi irrklqkkdp ahyttpeevv
     1141 sdvrlmfwnc akfnypdsev aeagrclevf fegwlkeiyp ekrfaqprqe dsdseevsse
     1201 sgcstpqgfp wppymqegiq pkrrrrhmen erakrmsfrl ansisqv
//
LOCUS       XP_054226641            1247 aa            linear   PRI 05-AUG-2025
DEFINITION  tripartite motif-containing protein 66 isoform X9 [Homo sapiens].
ACCESSION   XP_054226641
VERSION     XP_054226641.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370666.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1247
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1247
                     /product="tripartite motif-containing protein 66 isoform
                     X9"
                     /calculated_mol_wt=137825
     Region          4..40
                     /region_name="Bbox1_TRIM66"
                     /note="B-box-type 1 zinc finger found in tripartite
                     motif-containing protein 66 (TRIM66) and similar proteins;
                     cd19811"
                     /db_xref="CDD:380869"
     Region          63..105
                     /region_name="Bbox2_TRIM66-like"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing protein 66 (TRIM66) and similar proteins;
                     cd19794"
                     /db_xref="CDD:380852"
     Region          108..233
                     /region_name="BBC"
                     /note="B-Box C-terminal domain; smart00502"
                     /db_xref="CDD:128778"
     Region          1000..1048
                     /region_name="PHD_SF"
                     /note="PHD finger superfamily; cl22851"
                     /db_xref="CDD:473978"
     Site            order(1003,1013..1016,1020,1040)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:276966"
     Region          1073..1181
                     /region_name="Bromo_tif1_like"
                     /note="Bromodomain; tif1_like subfamily. Tif1
                     (transcription intermediary factor 1) is a member of the
                     tripartite motif (TRIM) protein family, which is
                     characterized by a particular domain architecture. It
                     functions by recruiting coactivators and/or...; cd05502"
                     /db_xref="CDD:99934"
     Site            order(1101,1105,1108,1150,1154,1160)
                     /site_type="other"
                     /note="putative acetyllysine binding site [chemical
                     binding]"
                     /db_xref="CDD:99934"
     CDS             1..1247
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /coded_by="XM_054370666.1:2017..5760"
                     /db_xref="GeneID:9866"
                     /db_xref="HGNC:HGNC:29005"
                     /db_xref="MIM:612000"
ORIGIN      
        1 marncsecke kraahilcty cnrwlcssct eehrhspvpg gpffpraqkg spgvnggpgd
       61 ftlycplhtq evlklfcetc dmltchsclv vehkehrcrh veevlqnqrm llegvttqva
      121 hkksslqtsa kqiedrifev khqhrkvenq ikmakmvlmn elnkqangli eelegitner
      181 krkleqqlqs imvlnrqfeh vqnfinwavc sktsvpflfs kelivfqmqr lletscntdp
      241 gspwsirftw epnfwtkqla slgcittegg qmsradapay gglqgsspfy qshqspvaqq
      301 ealshpshkf qspavcsssv ccsrcspvsp slkgqvppps ihpahsfrqp pemvpqqlgs
      361 lqcsallpre kelacsphpp kllqpwletq ppveqestsq rlgqqltsqp vcivppqdvq
      421 qgahaqptlq tpsiqvqfgh hqklklshfq qqpqqqlppp ppplprpppp lppppqqphp
      481 plppsqhlas sqhesppgpa csqnmdimhh kfeleemqkd lelllqaqqp slqlsqtksp
      541 qhlqqtivgq inyivrqpap vqsqsqeetl qatdeppasq gskpalpldk ntaaalpqas
      601 geetplsvpp vdstiqhssp nvvrkhstsl simgfsntle melsstrler plepqiqsvs
      661 nltagapqav psllsappkm vssltsvqnq ampslttshl qtvpslvhst fqsmpnlisd
      721 spqamaslas dhpqagpslm sghtqavpsl atcplqsipp vsdmqpetgs ssssgrtsgs
      781 lcprdgadps lenalckmes edstrftdll gqgpivpgld apkdlaipse leepinlsvk
      841 kpplapvvst stalqqyqnp kecenfeqga leldakenqs irafnsehki pyvrlerlki
      901 caassgempv fklkpqkndq dgsflliiec gtesssmsik vsqdrlseat qapglegrkv
      961 tvtslagqrp pevegtspee hrliprtpga kkgppapien edfcavclng gellccdrcp
     1021 kvfhlschvp allsfpggew vctlcrsltq pemeydcena cynqpgmras pglsmydqkk
     1081 ceklvlslcc nnlslpfhep vsplarhyyq iikrpmdlsi irrklqkkdp ahyttpeevv
     1141 sdvrlmfwnc akfnypdsev aeagrclevf fegwlkeiyp ekrfaqprqe dsdseevsse
     1201 sgcstpqgfp wppymqegiq pkrrrrhmen erakrmsfrl ansisqv
//
LOCUS       XP_054226642            1247 aa            linear   PRI 05-AUG-2025
DEFINITION  tripartite motif-containing protein 66 isoform X9 [Homo sapiens].
ACCESSION   XP_054226642
VERSION     XP_054226642.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370667.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1247
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1247
                     /product="tripartite motif-containing protein 66 isoform
                     X9"
                     /calculated_mol_wt=137825
     Region          4..40
                     /region_name="Bbox1_TRIM66"
                     /note="B-box-type 1 zinc finger found in tripartite
                     motif-containing protein 66 (TRIM66) and similar proteins;
                     cd19811"
                     /db_xref="CDD:380869"
     Region          63..105
                     /region_name="Bbox2_TRIM66-like"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing protein 66 (TRIM66) and similar proteins;
                     cd19794"
                     /db_xref="CDD:380852"
     Region          108..233
                     /region_name="BBC"
                     /note="B-Box C-terminal domain; smart00502"
                     /db_xref="CDD:128778"
     Region          1000..1048
                     /region_name="PHD_SF"
                     /note="PHD finger superfamily; cl22851"
                     /db_xref="CDD:473978"
     Site            order(1003,1013..1016,1020,1040)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:276966"
     Region          1073..1181
                     /region_name="Bromo_tif1_like"
                     /note="Bromodomain; tif1_like subfamily. Tif1
                     (transcription intermediary factor 1) is a member of the
                     tripartite motif (TRIM) protein family, which is
                     characterized by a particular domain architecture. It
                     functions by recruiting coactivators and/or...; cd05502"
                     /db_xref="CDD:99934"
     Site            order(1101,1105,1108,1150,1154,1160)
                     /site_type="other"
                     /note="putative acetyllysine binding site [chemical
                     binding]"
                     /db_xref="CDD:99934"
     CDS             1..1247
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /coded_by="XM_054370667.1:330..4073"
                     /db_xref="GeneID:9866"
                     /db_xref="HGNC:HGNC:29005"
                     /db_xref="MIM:612000"
ORIGIN      
        1 marncsecke kraahilcty cnrwlcssct eehrhspvpg gpffpraqkg spgvnggpgd
       61 ftlycplhtq evlklfcetc dmltchsclv vehkehrcrh veevlqnqrm llegvttqva
      121 hkksslqtsa kqiedrifev khqhrkvenq ikmakmvlmn elnkqangli eelegitner
      181 krkleqqlqs imvlnrqfeh vqnfinwavc sktsvpflfs kelivfqmqr lletscntdp
      241 gspwsirftw epnfwtkqla slgcittegg qmsradapay gglqgsspfy qshqspvaqq
      301 ealshpshkf qspavcsssv ccsrcspvsp slkgqvppps ihpahsfrqp pemvpqqlgs
      361 lqcsallpre kelacsphpp kllqpwletq ppveqestsq rlgqqltsqp vcivppqdvq
      421 qgahaqptlq tpsiqvqfgh hqklklshfq qqpqqqlppp ppplprpppp lppppqqphp
      481 plppsqhlas sqhesppgpa csqnmdimhh kfeleemqkd lelllqaqqp slqlsqtksp
      541 qhlqqtivgq inyivrqpap vqsqsqeetl qatdeppasq gskpalpldk ntaaalpqas
      601 geetplsvpp vdstiqhssp nvvrkhstsl simgfsntle melsstrler plepqiqsvs
      661 nltagapqav psllsappkm vssltsvqnq ampslttshl qtvpslvhst fqsmpnlisd
      721 spqamaslas dhpqagpslm sghtqavpsl atcplqsipp vsdmqpetgs ssssgrtsgs
      781 lcprdgadps lenalckmes edstrftdll gqgpivpgld apkdlaipse leepinlsvk
      841 kpplapvvst stalqqyqnp kecenfeqga leldakenqs irafnsehki pyvrlerlki
      901 caassgempv fklkpqkndq dgsflliiec gtesssmsik vsqdrlseat qapglegrkv
      961 tvtslagqrp pevegtspee hrliprtpga kkgppapien edfcavclng gellccdrcp
     1021 kvfhlschvp allsfpggew vctlcrsltq pemeydcena cynqpgmras pglsmydqkk
     1081 ceklvlslcc nnlslpfhep vsplarhyyq iikrpmdlsi irrklqkkdp ahyttpeevv
     1141 sdvrlmfwnc akfnypdsev aeagrclevf fegwlkeiyp ekrfaqprqe dsdseevsse
     1201 sgcstpqgfp wppymqegiq pkrrrrhmen erakrmsfrl ansisqv
//
LOCUS       XP_054226643            1247 aa            linear   PRI 05-AUG-2025
DEFINITION  tripartite motif-containing protein 66 isoform X9 [Homo sapiens].
ACCESSION   XP_054226643
VERSION     XP_054226643.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370668.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1247
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1247
                     /product="tripartite motif-containing protein 66 isoform
                     X9"
                     /calculated_mol_wt=137825
     Region          4..40
                     /region_name="Bbox1_TRIM66"
                     /note="B-box-type 1 zinc finger found in tripartite
                     motif-containing protein 66 (TRIM66) and similar proteins;
                     cd19811"
                     /db_xref="CDD:380869"
     Region          63..105
                     /region_name="Bbox2_TRIM66-like"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing protein 66 (TRIM66) and similar proteins;
                     cd19794"
                     /db_xref="CDD:380852"
     Region          108..233
                     /region_name="BBC"
                     /note="B-Box C-terminal domain; smart00502"
                     /db_xref="CDD:128778"
     Region          1000..1048
                     /region_name="PHD_SF"
                     /note="PHD finger superfamily; cl22851"
                     /db_xref="CDD:473978"
     Site            order(1003,1013..1016,1020,1040)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:276966"
     Region          1073..1181
                     /region_name="Bromo_tif1_like"
                     /note="Bromodomain; tif1_like subfamily. Tif1
                     (transcription intermediary factor 1) is a member of the
                     tripartite motif (TRIM) protein family, which is
                     characterized by a particular domain architecture. It
                     functions by recruiting coactivators and/or...; cd05502"
                     /db_xref="CDD:99934"
     Site            order(1101,1105,1108,1150,1154,1160)
                     /site_type="other"
                     /note="putative acetyllysine binding site [chemical
                     binding]"
                     /db_xref="CDD:99934"
     CDS             1..1247
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /coded_by="XM_054370668.1:331..4074"
                     /db_xref="GeneID:9866"
                     /db_xref="HGNC:HGNC:29005"
                     /db_xref="MIM:612000"
ORIGIN      
        1 marncsecke kraahilcty cnrwlcssct eehrhspvpg gpffpraqkg spgvnggpgd
       61 ftlycplhtq evlklfcetc dmltchsclv vehkehrcrh veevlqnqrm llegvttqva
      121 hkksslqtsa kqiedrifev khqhrkvenq ikmakmvlmn elnkqangli eelegitner
      181 krkleqqlqs imvlnrqfeh vqnfinwavc sktsvpflfs kelivfqmqr lletscntdp
      241 gspwsirftw epnfwtkqla slgcittegg qmsradapay gglqgsspfy qshqspvaqq
      301 ealshpshkf qspavcsssv ccsrcspvsp slkgqvppps ihpahsfrqp pemvpqqlgs
      361 lqcsallpre kelacsphpp kllqpwletq ppveqestsq rlgqqltsqp vcivppqdvq
      421 qgahaqptlq tpsiqvqfgh hqklklshfq qqpqqqlppp ppplprpppp lppppqqphp
      481 plppsqhlas sqhesppgpa csqnmdimhh kfeleemqkd lelllqaqqp slqlsqtksp
      541 qhlqqtivgq inyivrqpap vqsqsqeetl qatdeppasq gskpalpldk ntaaalpqas
      601 geetplsvpp vdstiqhssp nvvrkhstsl simgfsntle melsstrler plepqiqsvs
      661 nltagapqav psllsappkm vssltsvqnq ampslttshl qtvpslvhst fqsmpnlisd
      721 spqamaslas dhpqagpslm sghtqavpsl atcplqsipp vsdmqpetgs ssssgrtsgs
      781 lcprdgadps lenalckmes edstrftdll gqgpivpgld apkdlaipse leepinlsvk
      841 kpplapvvst stalqqyqnp kecenfeqga leldakenqs irafnsehki pyvrlerlki
      901 caassgempv fklkpqkndq dgsflliiec gtesssmsik vsqdrlseat qapglegrkv
      961 tvtslagqrp pevegtspee hrliprtpga kkgppapien edfcavclng gellccdrcp
     1021 kvfhlschvp allsfpggew vctlcrsltq pemeydcena cynqpgmras pglsmydqkk
     1081 ceklvlslcc nnlslpfhep vsplarhyyq iikrpmdlsi irrklqkkdp ahyttpeevv
     1141 sdvrlmfwnc akfnypdsev aeagrclevf fegwlkeiyp ekrfaqprqe dsdseevsse
     1201 sgcstpqgfp wppymqegiq pkrrrrhmen erakrmsfrl ansisqv
//
LOCUS       XP_054226644            1247 aa            linear   PRI 05-AUG-2025
DEFINITION  tripartite motif-containing protein 66 isoform X9 [Homo sapiens].
ACCESSION   XP_054226644
VERSION     XP_054226644.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370669.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1247
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1247
                     /product="tripartite motif-containing protein 66 isoform
                     X9"
                     /calculated_mol_wt=137825
     Region          4..40
                     /region_name="Bbox1_TRIM66"
                     /note="B-box-type 1 zinc finger found in tripartite
                     motif-containing protein 66 (TRIM66) and similar proteins;
                     cd19811"
                     /db_xref="CDD:380869"
     Region          63..105
                     /region_name="Bbox2_TRIM66-like"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing protein 66 (TRIM66) and similar proteins;
                     cd19794"
                     /db_xref="CDD:380852"
     Region          108..233
                     /region_name="BBC"
                     /note="B-Box C-terminal domain; smart00502"
                     /db_xref="CDD:128778"
     Region          1000..1048
                     /region_name="PHD_SF"
                     /note="PHD finger superfamily; cl22851"
                     /db_xref="CDD:473978"
     Site            order(1003,1013..1016,1020,1040)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:276966"
     Region          1073..1181
                     /region_name="Bromo_tif1_like"
                     /note="Bromodomain; tif1_like subfamily. Tif1
                     (transcription intermediary factor 1) is a member of the
                     tripartite motif (TRIM) protein family, which is
                     characterized by a particular domain architecture. It
                     functions by recruiting coactivators and/or...; cd05502"
                     /db_xref="CDD:99934"
     Site            order(1101,1105,1108,1150,1154,1160)
                     /site_type="other"
                     /note="putative acetyllysine binding site [chemical
                     binding]"
                     /db_xref="CDD:99934"
     CDS             1..1247
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /coded_by="XM_054370669.1:548..4291"
                     /db_xref="GeneID:9866"
                     /db_xref="HGNC:HGNC:29005"
                     /db_xref="MIM:612000"
ORIGIN      
        1 marncsecke kraahilcty cnrwlcssct eehrhspvpg gpffpraqkg spgvnggpgd
       61 ftlycplhtq evlklfcetc dmltchsclv vehkehrcrh veevlqnqrm llegvttqva
      121 hkksslqtsa kqiedrifev khqhrkvenq ikmakmvlmn elnkqangli eelegitner
      181 krkleqqlqs imvlnrqfeh vqnfinwavc sktsvpflfs kelivfqmqr lletscntdp
      241 gspwsirftw epnfwtkqla slgcittegg qmsradapay gglqgsspfy qshqspvaqq
      301 ealshpshkf qspavcsssv ccsrcspvsp slkgqvppps ihpahsfrqp pemvpqqlgs
      361 lqcsallpre kelacsphpp kllqpwletq ppveqestsq rlgqqltsqp vcivppqdvq
      421 qgahaqptlq tpsiqvqfgh hqklklshfq qqpqqqlppp ppplprpppp lppppqqphp
      481 plppsqhlas sqhesppgpa csqnmdimhh kfeleemqkd lelllqaqqp slqlsqtksp
      541 qhlqqtivgq inyivrqpap vqsqsqeetl qatdeppasq gskpalpldk ntaaalpqas
      601 geetplsvpp vdstiqhssp nvvrkhstsl simgfsntle melsstrler plepqiqsvs
      661 nltagapqav psllsappkm vssltsvqnq ampslttshl qtvpslvhst fqsmpnlisd
      721 spqamaslas dhpqagpslm sghtqavpsl atcplqsipp vsdmqpetgs ssssgrtsgs
      781 lcprdgadps lenalckmes edstrftdll gqgpivpgld apkdlaipse leepinlsvk
      841 kpplapvvst stalqqyqnp kecenfeqga leldakenqs irafnsehki pyvrlerlki
      901 caassgempv fklkpqkndq dgsflliiec gtesssmsik vsqdrlseat qapglegrkv
      961 tvtslagqrp pevegtspee hrliprtpga kkgppapien edfcavclng gellccdrcp
     1021 kvfhlschvp allsfpggew vctlcrsltq pemeydcena cynqpgmras pglsmydqkk
     1081 ceklvlslcc nnlslpfhep vsplarhyyq iikrpmdlsi irrklqkkdp ahyttpeevv
     1141 sdvrlmfwnc akfnypdsev aeagrclevf fegwlkeiyp ekrfaqprqe dsdseevsse
     1201 sgcstpqgfp wppymqegiq pkrrrrhmen erakrmsfrl ansisqv
//
LOCUS       XP_054226645            1247 aa            linear   PRI 05-AUG-2025
DEFINITION  tripartite motif-containing protein 66 isoform X9 [Homo sapiens].
ACCESSION   XP_054226645
VERSION     XP_054226645.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370670.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1247
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1247
                     /product="tripartite motif-containing protein 66 isoform
                     X9"
                     /calculated_mol_wt=137825
     Region          4..40
                     /region_name="Bbox1_TRIM66"
                     /note="B-box-type 1 zinc finger found in tripartite
                     motif-containing protein 66 (TRIM66) and similar proteins;
                     cd19811"
                     /db_xref="CDD:380869"
     Region          63..105
                     /region_name="Bbox2_TRIM66-like"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing protein 66 (TRIM66) and similar proteins;
                     cd19794"
                     /db_xref="CDD:380852"
     Region          108..233
                     /region_name="BBC"
                     /note="B-Box C-terminal domain; smart00502"
                     /db_xref="CDD:128778"
     Region          1000..1048
                     /region_name="PHD_SF"
                     /note="PHD finger superfamily; cl22851"
                     /db_xref="CDD:473978"
     Site            order(1003,1013..1016,1020,1040)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:276966"
     Region          1073..1181
                     /region_name="Bromo_tif1_like"
                     /note="Bromodomain; tif1_like subfamily. Tif1
                     (transcription intermediary factor 1) is a member of the
                     tripartite motif (TRIM) protein family, which is
                     characterized by a particular domain architecture. It
                     functions by recruiting coactivators and/or...; cd05502"
                     /db_xref="CDD:99934"
     Site            order(1101,1105,1108,1150,1154,1160)
                     /site_type="other"
                     /note="putative acetyllysine binding site [chemical
                     binding]"
                     /db_xref="CDD:99934"
     CDS             1..1247
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /coded_by="XM_054370670.1:1872..5615"
                     /db_xref="GeneID:9866"
                     /db_xref="HGNC:HGNC:29005"
                     /db_xref="MIM:612000"
ORIGIN      
        1 marncsecke kraahilcty cnrwlcssct eehrhspvpg gpffpraqkg spgvnggpgd
       61 ftlycplhtq evlklfcetc dmltchsclv vehkehrcrh veevlqnqrm llegvttqva
      121 hkksslqtsa kqiedrifev khqhrkvenq ikmakmvlmn elnkqangli eelegitner
      181 krkleqqlqs imvlnrqfeh vqnfinwavc sktsvpflfs kelivfqmqr lletscntdp
      241 gspwsirftw epnfwtkqla slgcittegg qmsradapay gglqgsspfy qshqspvaqq
      301 ealshpshkf qspavcsssv ccsrcspvsp slkgqvppps ihpahsfrqp pemvpqqlgs
      361 lqcsallpre kelacsphpp kllqpwletq ppveqestsq rlgqqltsqp vcivppqdvq
      421 qgahaqptlq tpsiqvqfgh hqklklshfq qqpqqqlppp ppplprpppp lppppqqphp
      481 plppsqhlas sqhesppgpa csqnmdimhh kfeleemqkd lelllqaqqp slqlsqtksp
      541 qhlqqtivgq inyivrqpap vqsqsqeetl qatdeppasq gskpalpldk ntaaalpqas
      601 geetplsvpp vdstiqhssp nvvrkhstsl simgfsntle melsstrler plepqiqsvs
      661 nltagapqav psllsappkm vssltsvqnq ampslttshl qtvpslvhst fqsmpnlisd
      721 spqamaslas dhpqagpslm sghtqavpsl atcplqsipp vsdmqpetgs ssssgrtsgs
      781 lcprdgadps lenalckmes edstrftdll gqgpivpgld apkdlaipse leepinlsvk
      841 kpplapvvst stalqqyqnp kecenfeqga leldakenqs irafnsehki pyvrlerlki
      901 caassgempv fklkpqkndq dgsflliiec gtesssmsik vsqdrlseat qapglegrkv
      961 tvtslagqrp pevegtspee hrliprtpga kkgppapien edfcavclng gellccdrcp
     1021 kvfhlschvp allsfpggew vctlcrsltq pemeydcena cynqpgmras pglsmydqkk
     1081 ceklvlslcc nnlslpfhep vsplarhyyq iikrpmdlsi irrklqkkdp ahyttpeevv
     1141 sdvrlmfwnc akfnypdsev aeagrclevf fegwlkeiyp ekrfaqprqe dsdseevsse
     1201 sgcstpqgfp wppymqegiq pkrrrrhmen erakrmsfrl ansisqv
//
LOCUS       XP_054226646            1219 aa            linear   PRI 05-AUG-2025
DEFINITION  tripartite motif-containing protein 66 isoform X10 [Homo sapiens].
ACCESSION   XP_054226646
VERSION     XP_054226646.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370671.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1219
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1219
                     /product="tripartite motif-containing protein 66 isoform
                     X10"
                     /calculated_mol_wt=134944
     Region          4..40
                     /region_name="Bbox1_TRIM66"
                     /note="B-box-type 1 zinc finger found in tripartite
                     motif-containing protein 66 (TRIM66) and similar proteins;
                     cd19811"
                     /db_xref="CDD:380869"
     Region          63..105
                     /region_name="Bbox2_TRIM66-like"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing protein 66 (TRIM66) and similar proteins;
                     cd19794"
                     /db_xref="CDD:380852"
     Region          108..233
                     /region_name="BBC"
                     /note="B-Box C-terminal domain; smart00502"
                     /db_xref="CDD:128778"
     Region          972..1020
                     /region_name="PHD_SF"
                     /note="PHD finger superfamily; cl22851"
                     /db_xref="CDD:473978"
     Site            order(975,985..988,992,1012)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:276966"
     Region          1045..1153
                     /region_name="Bromo_tif1_like"
                     /note="Bromodomain; tif1_like subfamily. Tif1
                     (transcription intermediary factor 1) is a member of the
                     tripartite motif (TRIM) protein family, which is
                     characterized by a particular domain architecture. It
                     functions by recruiting coactivators and/or...; cd05502"
                     /db_xref="CDD:99934"
     Site            order(1073,1077,1080,1122,1126,1132)
                     /site_type="other"
                     /note="putative acetyllysine binding site [chemical
                     binding]"
                     /db_xref="CDD:99934"
     CDS             1..1219
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /coded_by="XM_054370671.1:3223..6882"
                     /db_xref="GeneID:9866"
                     /db_xref="HGNC:HGNC:29005"
                     /db_xref="MIM:612000"
ORIGIN      
        1 marncsecke kraahilcty cnrwlcssct eehrhspvpg gpffpraqkg spgvnggpgd
       61 ftlycplhtq evlklfcetc dmltchsclv vehkehrcrh veevlqnqrm llegvttqva
      121 hkksslqtsa kqiedrifev khqhrkvenq ikmakmvlmn elnkqangli eelegitner
      181 krkleqqlqs imvlnrqfeh vqnfinwavc sktsvpflfs kelivfqmqr lletscntdp
      241 gspwsirftw epnfwtkqla slgcittegg qmsradapay gglqgsspfy qshqspvaqq
      301 ealshpshkf qspavcsssv ccsrcspvsp slkgqvppps ihpahsfrqp pemvpqqlgs
      361 lqcsallpre kelacsphpp kllqpwletq ppveqestsq rlgqqltsqp vcivppqdvq
      421 qgahaqptlq tpsiqvqfgh hqklklshfq qqpqqqlppp ppplprpppp lppppqqphp
      481 plppsqhlas sqhesppgpa csqnmdimhh kfeleemqkd lelllqaqqp slqlsqtksp
      541 qhlqqtivgq inyivrqpap vqsqsqeetl qatdeppasq gskpalpldk ntaaalpqas
      601 geetplsvpp vdstiqhssp nvvrkhstsl simgfsntle melsstrler plepqiqsvs
      661 nltagapqav psllsappkm vssltsvqnq ampslttshl qtvpslvhst fqsmpnlisd
      721 spqamaslas dhpqagpslm sghtqavpsl atcplqsipp vsdmqpetgs ssssgrtsgs
      781 lcprdgadps lenalckmes edstrftdll gqgpivpgld apkdlaipse leepinlsvk
      841 kpplapvvst stalqqyqnp kecenfeqga leldakenqs irafnsehki pyvrlerlki
      901 caassgempv fklkpqkndq dgsflliiec gtesssmsik rppevegtsp eehrliprtp
      961 gakkgppapi enedfcavcl nggellccdr cpkvfhlsch vpallsfpgg ewvctlcrsl
     1021 tqpemeydce nacynqpgmr aspglsmydq kkceklvlsl ccnnlslpfh epvsplarhy
     1081 yqiikrpmdl siirrklqkk dpahyttpee vvsdvrlmfw ncakfnypds evaeagrcle
     1141 vffegwlkei ypekrfaqpr qedsdseevs sesgcstpqg fpwppymqeg iqpkrrrrhm
     1201 enerakrmsf rlansisqv
//
LOCUS       XP_054226647            1032 aa            linear   PRI 05-AUG-2025
DEFINITION  tripartite motif-containing protein 66 isoform X11 [Homo sapiens].
ACCESSION   XP_054226647
VERSION     XP_054226647.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370672.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1032
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1032
                     /product="tripartite motif-containing protein 66 isoform
                     X11"
                     /calculated_mol_wt=112985
     Region          149..185
                     /region_name="Bbox1_TRIM66"
                     /note="B-box-type 1 zinc finger found in tripartite
                     motif-containing protein 66 (TRIM66) and similar proteins;
                     cd19811"
                     /db_xref="CDD:380869"
     Region          208..250
                     /region_name="Bbox2_TRIM66-like"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing protein 66 (TRIM66) and similar proteins;
                     cd19794"
                     /db_xref="CDD:380852"
     Region          253..378
                     /region_name="BBC"
                     /note="B-Box C-terminal domain; smart00502"
                     /db_xref="CDD:128778"
     CDS             1..1032
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /coded_by="XM_054370672.1:613..3711"
                     /db_xref="GeneID:9866"
                     /db_xref="HGNC:HGNC:29005"
                     /db_xref="MIM:612000"
ORIGIN      
        1 marlsfwsqg velarstrcf spedisgkap vlgtgmavdm gmsfmglpla gqkhcpksgq
       61 meamvmtcsl chqdlpgmgs hllscqhllr kdcfqgliqe lgqiakahet vadeliscpg
      121 cervyltrdv tehfflhcvp teqpkmarnc seckekraah ilctycnrwl csscteehrh
      181 spvpggpffp raqkgspgvn ggpgdftlyc plhtqevlkl fcetcdmltc hsclvvehke
      241 hrcrhveevl qnqrmllegv ttqvahkkss lqtsakqied rifevkhqhr kvenqikmak
      301 mvlmnelnkq anglieeleg itnerkrkle qqlqsimvln rqfehvqnfi nwavcsktsv
      361 pflfskeliv fqmqrllets cntdpgspws irftwepnfw tkqlaslgci tteggqmsra
      421 dapaygglqg sspfyqshqs pvaqqealsh pshkfqspav csssvccsrc spvspslkgq
      481 vpppsihpah sfrqppemvp qqlgslqcsa llprekelac sphppkllqp wletqppveq
      541 estsqrlgqq ltsqpvcivp pqdvqqgaha qptlqtpsiq vqfghhqklk lshfqqqpqq
      601 qlpppppplp rpppplpppp qqphpplpps qhlassqhes ppgpacsqnm dimhhkfele
      661 emqkdlelll qaqqpslqls qtkspqhlqq tivgqinyiv rqpapvqsqs qeetlqatde
      721 ppasqgskpa lpldkntaaa lpqasgeetp lsvppvdsti qhsspnvvrk hstslsimgf
      781 sntlemelss trlerplepq iqsvsnltag apqavpslls appkmvsslt svqnqampsl
      841 ttshlqtvps lvhstfqsmp nlisdspqam aslasdhpqa gpslmsghtq avpslatcpl
      901 qsippvsdmq petgsssssg rtsgslcprd gadpslenal ckmesedstr ftdllgqgpi
      961 vpgldapkdl aipseleepi nlsvkkppla pvvststalq qyqnpkecen feqgalelda
     1021 kenqsirdhg cf
//
LOCUS       XP_054226648            1020 aa            linear   PRI 05-AUG-2025
DEFINITION  tripartite motif-containing protein 66 isoform X12 [Homo sapiens].
ACCESSION   XP_054226648
VERSION     XP_054226648.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370673.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1020
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1020
                     /product="tripartite motif-containing protein 66 isoform
                     X12"
                     /calculated_mol_wt=111481
     Region          149..185
                     /region_name="Bbox1_TRIM66"
                     /note="B-box-type 1 zinc finger found in tripartite
                     motif-containing protein 66 (TRIM66) and similar proteins;
                     cd19811"
                     /db_xref="CDD:380869"
     Region          208..250
                     /region_name="Bbox2_TRIM66-like"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing protein 66 (TRIM66) and similar proteins;
                     cd19794"
                     /db_xref="CDD:380852"
     Region          253..378
                     /region_name="BBC"
                     /note="B-Box C-terminal domain; smart00502"
                     /db_xref="CDD:128778"
     CDS             1..1020
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /coded_by="XM_054370673.1:613..3675"
                     /db_xref="GeneID:9866"
                     /db_xref="HGNC:HGNC:29005"
                     /db_xref="MIM:612000"
ORIGIN      
        1 marlsfwsqg velarstrcf spedisgkap vlgtgmavdm gmsfmglpla gqkhcpksgq
       61 meamvmtcsl chqdlpgmgs hllscqhllr kdcfqgliqe lgqiakahet vadeliscpg
      121 cervyltrdv tehfflhcvp teqpkmarnc seckekraah ilctycnrwl csscteehrh
      181 spvpggpffp raqkgspgvn ggpgdftlyc plhtqevlkl fcetcdmltc hsclvvehke
      241 hrcrhveevl qnqrmllegv ttqvahkkss lqtsakqied rifevkhqhr kvenqikmak
      301 mvlmnelnkq anglieeleg itnerkrkle qqlqsimvln rqfehvqnfi nwavcsktsv
      361 pflfskeliv fqmqrllets cntdpgspws irftwepnfw tkqlaslgci tteggqmsra
      421 dapaygglqg sspfyqshqs pvaqqealsh pshkfqspav csssvccsrc spvspslkgq
      481 vpppsihpah sfrqppemvp qqlgslqcsa llprekelac sphppkllqp wletqppveq
      541 estsqrlgqq ltsqpvcivp pqdvqqgaha qptlqtpsiq vqfghhqklk lshfqqqpqq
      601 qlpppppplp rpppplpppp qqphpplpps qhlassqhes ppgpacsqnm dimhhkfele
      661 emqkdlelll qaqqpslqls qtkspqhlqq tivgqinyiv rqpapvqsqs qeetlqatde
      721 ppasqgskpa lpldkntaaa lpqasgeetp lsvppvdsti qhsspnvvrk hstslsimgf
      781 sntlemelss trlerplepq iqsvsnltag apqavpslls appkmvsslt svqnqampsl
      841 ttshlqtvps lvhstfqsmp nlisdspqam aslasdhpqa gpslmsghtq avpslatcpl
      901 qsippvsdmq petgsssssg rtsgslcprd gadpslenal ckmesedstr ftdllgqgpi
      961 vpgldapkdl aipseleepi nlsvkkppla pvvststalq qyqnpkgetq aacpscwpqt
//
LOCUS       XP_054226649            1001 aa            linear   PRI 05-AUG-2025
DEFINITION  tripartite motif-containing protein 66 isoform X13 [Homo sapiens].
ACCESSION   XP_054226649
VERSION     XP_054226649.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370674.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1001
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1001
                     /product="tripartite motif-containing protein 66 isoform
                     X13"
                     /calculated_mol_wt=109338
     Region          754..802
                     /region_name="PHD_TIF1delta"
                     /note="PHD finger found in transcriptional intermediary
                     factor 1 delta (TIF1delta); cd15625"
                     /db_xref="CDD:277095"
     Site            order(754..757,762..771,778,789..792)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:277095"
     Region          827..935
                     /region_name="Bromo_tif1_like"
                     /note="Bromodomain; tif1_like subfamily. Tif1
                     (transcription intermediary factor 1) is a member of the
                     tripartite motif (TRIM) protein family, which is
                     characterized by a particular domain architecture. It
                     functions by recruiting coactivators and/or...; cd05502"
                     /db_xref="CDD:99934"
     Site            order(855,859,862,904,908,914)
                     /site_type="other"
                     /note="putative acetyllysine binding site [chemical
                     binding]"
                     /db_xref="CDD:99934"
     CDS             1..1001
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /coded_by="XM_054370674.1:93..3098"
                     /db_xref="GeneID:9866"
                     /db_xref="HGNC:HGNC:29005"
                     /db_xref="MIM:612000"
ORIGIN      
        1 mlygstdecv slwshkgcit teggqmsrad apaygglqgs spfyqshqsp vaqqealshp
       61 shkfqspavc sssvccsrcs pvspslkgqv pppsihpahs frqppemvpq qlgslqcsal
      121 lprekelacs phppkllqpw letqppveqe stsqrlgqql tsqpvcivpp qdvqqgahaq
      181 ptlqtpsiqv qfghhqklkl shfqqqpqqq lpppppplpr pppplppppq qphpplppsq
      241 hlassqhesp pgpacsqnmd imhhkfelee mqkdlelllq aqqpslqlsq tkspqhlqqt
      301 ivgqinyivr qpapvqsqsq eetlqatdep pasqgskpal pldkntaaal pqasgeetpl
      361 svppvdstiq hsspnvvrkh stslsimgfs ntlemelsst rlerplepqi qsvsnltaga
      421 pqavpsllsa ppkmvsslts vqnqampslt tshlqtvpsl vhstfqsmpn lisdspqama
      481 slasdhpqag pslmsghtqa vpslatcplq sippvsdmqp etgsssssgr tsgslcprdg
      541 adpslenalc kmesedstrf tdllgqgpiv pgldapkdla ipseleepin lsvkkpplap
      601 vvststalqq yqnpkecenf eqgaleldak enqsirafns ehkipyvrle rlkicaassg
      661 empvfklkpq kndqdgsfll iiecgtesss msikvsqdrl seatqapgle grkvtvtsla
      721 gqrppevegt speehrlipr tpgakkgppa pienedfcav clnggellcc drcpkvfhls
      781 chvpallsfp ggewvctlcr sltqpemeyd cenacynqpg mraspglsmy dqkkceklvl
      841 slccnnlslp fhepvsplar hyyqiikrpm dlsiirrklq kkdpahyttp eevvsdvrlm
      901 fwncakfnyp dsevaeagrc levffegwlk eiypekrfaq prqedsdsee vssesgcstp
      961 qgfpwppymq egiqpkrrrr hmenerakrm sfrlansisq v
//
LOCUS       XP_054226650             973 aa            linear   PRI 05-AUG-2025
DEFINITION  tripartite motif-containing protein 66 isoform X14 [Homo sapiens].
ACCESSION   XP_054226650
VERSION     XP_054226650.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370675.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..973
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..973
                     /product="tripartite motif-containing protein 66 isoform
                     X14"
                     /calculated_mol_wt=106457
     Region          726..774
                     /region_name="PHD_TIF1delta"
                     /note="PHD finger found in transcriptional intermediary
                     factor 1 delta (TIF1delta); cd15625"
                     /db_xref="CDD:277095"
     Site            order(726..729,734..743,750,761..764)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:277095"
     Region          799..907
                     /region_name="Bromo_tif1_like"
                     /note="Bromodomain; tif1_like subfamily. Tif1
                     (transcription intermediary factor 1) is a member of the
                     tripartite motif (TRIM) protein family, which is
                     characterized by a particular domain architecture. It
                     functions by recruiting coactivators and/or...; cd05502"
                     /db_xref="CDD:99934"
     Site            order(827,831,834,876,880,886)
                     /site_type="other"
                     /note="putative acetyllysine binding site [chemical
                     binding]"
                     /db_xref="CDD:99934"
     CDS             1..973
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /coded_by="XM_054370675.1:156..3077"
                     /db_xref="GeneID:9866"
                     /db_xref="HGNC:HGNC:29005"
                     /db_xref="MIM:612000"
ORIGIN      
        1 mlygstdecv slwshkgcit teggqmsrad apaygglqgs spfyqshqsp vaqqealshp
       61 shkfqspavc sssvccsrcs pvspslkgqv pppsihpahs frqppemvpq qlgslqcsal
      121 lprekelacs phppkllqpw letqppveqe stsqrlgqql tsqpvcivpp qdvqqgahaq
      181 ptlqtpsiqv qfghhqklkl shfqqqpqqq lpppppplpr pppplppppq qphpplppsq
      241 hlassqhesp pgpacsqnmd imhhkfelee mqkdlelllq aqqpslqlsq tkspqhlqqt
      301 ivgqinyivr qpapvqsqsq eetlqatdep pasqgskpal pldkntaaal pqasgeetpl
      361 svppvdstiq hsspnvvrkh stslsimgfs ntlemelsst rlerplepqi qsvsnltaga
      421 pqavpsllsa ppkmvsslts vqnqampslt tshlqtvpsl vhstfqsmpn lisdspqama
      481 slasdhpqag pslmsghtqa vpslatcplq sippvsdmqp etgsssssgr tsgslcprdg
      541 adpslenalc kmesedstrf tdllgqgpiv pgldapkdla ipseleepin lsvkkpplap
      601 vvststalqq yqnpkecenf eqgaleldak enqsirafns ehkipyvrle rlkicaassg
      661 empvfklkpq kndqdgsfll iiecgtesss msikrppeve gtspeehrli prtpgakkgp
      721 papienedfc avclnggell ccdrcpkvfh lschvpalls fpggewvctl crsltqpeme
      781 ydcenacynq pgmraspgls mydqkkcekl vlslccnnls lpfhepvspl arhyyqiikr
      841 pmdlsiirrk lqkkdpahyt tpeevvsdvr lmfwncakfn ypdsevaeag rclevffegw
      901 lkeiypekrf aqprqedsds eevssesgcs tpqgfpwppy mqegiqpkrr rrhmenerak
      961 rmsfrlansi sqv
//
LOCUS       XP_054226651             743 aa            linear   PRI 05-AUG-2025
DEFINITION  tripartite motif-containing protein 66 isoform X15 [Homo sapiens].
ACCESSION   XP_054226651
VERSION     XP_054226651.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370676.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..743
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..743
                     /product="tripartite motif-containing protein 66 isoform
                     X15"
                     /calculated_mol_wt=81493
     Region          496..544
                     /region_name="PHD_TIF1delta"
                     /note="PHD finger found in transcriptional intermediary
                     factor 1 delta (TIF1delta); cd15625"
                     /db_xref="CDD:277095"
     Site            order(496..499,504..513,520,531..534)
                     /site_type="other"
                     /note="histone H3 binding site [polypeptide binding]"
                     /db_xref="CDD:277095"
     Region          569..677
                     /region_name="Bromo_tif1_like"
                     /note="Bromodomain; tif1_like subfamily. Tif1
                     (transcription intermediary factor 1) is a member of the
                     tripartite motif (TRIM) protein family, which is
                     characterized by a particular domain architecture. It
                     functions by recruiting coactivators and/or...; cd05502"
                     /db_xref="CDD:99934"
     Site            order(597,601,604,646,650,656)
                     /site_type="other"
                     /note="putative acetyllysine binding site [chemical
                     binding]"
                     /db_xref="CDD:99934"
     CDS             1..743
                     /gene="TRIM66"
                     /gene_synonym="C11orf29; TIF1D; TIF1DELTA"
                     /coded_by="XM_054370676.1:132..2363"
                     /db_xref="GeneID:9866"
                     /db_xref="HGNC:HGNC:29005"
                     /db_xref="MIM:612000"
ORIGIN      
        1 mdimhhkfel eemqkdlell lqaqqpslql sqtkspqhlq qtivgqinyi vrqpapvqsq
       61 sqeetlqatd eppasqgskp alpldkntaa alpqasgeet plsvppvdst iqhsspnvvr
      121 khstslsimg fsntlemels strlerplep qiqsvsnlta gapqavpsll sappkmvssl
      181 tsvqnqamps lttshlqtvp slvhstfqsm pnlisdspqa maslasdhpq agpslmsght
      241 qavpslatcp lqsippvsdm qpetgsssss grtsgslcpr dgadpslena lckmesedst
      301 rftdllgqgp ivpgldapkd laipseleep inlsvkkppl apvvststal qqyqnpkece
      361 nfeqgaleld akenqsiraf nsehkipyvr lerlkicaas sgempvfklk pqkndqdgsf
      421 lliiecgtes ssmsikvsqd rlseatqapg legrkvtvts lagqrppeve gtspeehrli
      481 prtpgakkgp papienedfc avclnggell ccdrcpkvfh lschvpalls fpggewvctl
      541 crsltqpeme ydcenacynq pgmraspgls mydqkkcekl vlslccnnls lpfhepvspl
      601 arhyyqiikr pmdlsiirrk lqkkdpahyt tpeevvsdvr lmfwncakfn ypdsevaeag
      661 rclevffegw lkeiypekrf aqprqedsds eevssesgcs tpqgfpwppy mqegiqpkrr
      721 rrhmenerak rmsfrlansi sqv
//
LOCUS       XP_054226652             719 aa            linear   PRI 05-AUG-2025
DEFINITION  F-BAR and double SH3 domains protein 2 isoform X1 [Homo sapiens].
ACCESSION   XP_054226652
VERSION     XP_054226652.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370677.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..719
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..719
                     /product="F-BAR and double SH3 domains protein 2 isoform
                     X1"
                     /calculated_mol_wt=81673
     Region          1..254
                     /region_name="F-BAR_FCHSD2"
                     /note="The F-BAR (FES-CIP4 Homology and
                     Bin/Amphiphysin/Rvs) domain of FCH and double SH3 domains
                     2 (FCHSD2); cd07677"
                     /db_xref="CDD:153361"
     Site            order(3,10,13..14,17,20..21,24..25,28,32,35,39,72,75,173,
                     177,202,207,210,213..214,217,221,224,228,232,235..236,239)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:153361"
     Region          450..506
                     /region_name="SH3_FCHSD_1"
                     /note="First Src Homology 3 domain of FCH and double SH3
                     domains proteins; cd11761"
                     /db_xref="CDD:212695"
     Site            order(457,459,462,466,485..486,500,502..503)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212695"
     Region          550..605
                     /region_name="SH3_FCHSD2_2"
                     /note="Second Src Homology 3 domain of FCH and double SH3
                     domains protein 2; cd11894"
                     /db_xref="CDD:212827"
     Site            order(555,557,560,564,585..586,599,601..602)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212827"
     CDS             1..719
                     /gene="FCHSD2"
                     /gene_synonym="NWK; NWK1; SH3MD3"
                     /coded_by="XM_054370677.1:180..2339"
                     /db_xref="GeneID:9873"
                     /db_xref="HGNC:HGNC:29114"
                     /db_xref="MIM:617556"
ORIGIN      
        1 mtklqakhqa ecdlledmrt fsqkkaaier eyaqgmqkla sqylkrdwpg vkaddrndyr
       61 smypvwksfl egtmqvaqsr mnicenyknf isepartvrs lkeqqlkrcv dqltkiqtel
      121 qetvkdlakg kkkyfeteqm ahavrekadi eaksklslfq srislqkasv klkarrsecn
      181 skatharndy lltlaaanah qdryyqtdlv nimkaldgnv ydhlkdylia fsrteletcq
      241 avqntfqfll ensskvvrdy nlqlflqena vfhkpqpfqf qpcdsdtsrq lesetgttee
      301 hslnkearkw atrvarehkn ivhqqrvlnd lechgaavse qsraeleqki dearenirka
      361 eiiklkaear ldllkqigvs vdtwlksamn qvmeelener warppavtsn gtlhslnadt
      421 ereegeefed nmdvfddsss spsgtlrnyp ltckvvysyk asqpdeltie ehevlevied
      481 gdmedwvkar nkvgqvgyvp ekylqfptsn sllsmlqsla aldsrshtss nsteaelvsg
      541 slngdasvcf vkalydyegq tddelsfpeg aiirilnken qdddgfwege fngrigvfps
      601 vlveelsase ngdtpwmrei qispspkpha slpplplydq ppsspypspd krsslyfprs
      661 psanekslha espgfsqasr htpetsygkl rpvraapppp tqnhrrpaek iedveitlv
//
LOCUS       XP_054226653             715 aa            linear   PRI 05-AUG-2025
DEFINITION  F-BAR and double SH3 domains protein 2 isoform X2 [Homo sapiens].
ACCESSION   XP_054226653
VERSION     XP_054226653.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370678.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..715
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..715
                     /product="F-BAR and double SH3 domains protein 2 isoform
                     X2"
                     /calculated_mol_wt=81288
     Region          30..250
                     /region_name="BAR"
                     /note="The Bin/Amphiphysin/Rvs (BAR) domain, a
                     dimerization module that binds membranes and detects
                     membrane curvature; cl12013"
                     /db_xref="CDD:472257"
     Region          446..502
                     /region_name="SH3_FCHSD_1"
                     /note="First Src Homology 3 domain of FCH and double SH3
                     domains proteins; cd11761"
                     /db_xref="CDD:212695"
     Site            order(453,455,458,462,481..482,496,498..499)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212695"
     Region          546..601
                     /region_name="SH3_FCHSD2_2"
                     /note="Second Src Homology 3 domain of FCH and double SH3
                     domains protein 2; cd11894"
                     /db_xref="CDD:212827"
     Site            order(551,553,556,560,581..582,595,597..598)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212827"
     CDS             1..715
                     /gene="FCHSD2"
                     /gene_synonym="NWK; NWK1; SH3MD3"
                     /coded_by="XM_054370678.1:112..2259"
                     /db_xref="GeneID:9873"
                     /db_xref="HGNC:HGNC:29114"
                     /db_xref="MIM:617556"
ORIGIN      
        1 mhrvwlprfr klcdqssmem dscvpcdmpe gmqklasqyl krdwpgvkad drndyrsmyp
       61 vwksflegtm qvaqsrmnic enyknfisep artvrslkeq qlkrcvdqlt kiqtelqetv
      121 kdlakgkkky feteqmahav rekadieaks klslfqsris lqkasvklka rrsecnskat
      181 harndylltl aaanahqdry yqtdlvnimk aldgnvydhl kdyliafsrt eletcqavqn
      241 tfqfllenss kvvrdynlql flqenavfhk pqpfqfqpcd sdtsrqlese tgtteehsln
      301 kearkwatrv arehknivhq qrvlndlech gaavseqsra eleqkidear enirkaeiik
      361 lkaearldll kqigvsvdtw lksamnqvme elenerwarp pavtsngtlh slnadteree
      421 geefednmdv fddsssspsg tlrnypltck vvysykasqp deltieehev leviedgdme
      481 dwvkarnkvg qvgyvpekyl qfptsnslls mlqslaalds rshtssnste aelvsgslng
      541 dasvcfvkal ydyegqtdde lsfpegaiir ilnkenqddd gfwegefngr igvfpsvlve
      601 elsasengdt pwmreiqisp spkphaslpp lplydqppss pypspdkrss lyfprspsan
      661 ekslhaespg fsqasrhtpe tsygklrpvr aapppptqnh rrpaekiedv eitlv
//
LOCUS       XP_054226654             597 aa            linear   PRI 05-AUG-2025
DEFINITION  F-BAR and double SH3 domains protein 2 isoform X4 [Homo sapiens].
ACCESSION   XP_054226654
VERSION     XP_054226654.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370679.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..597
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..597
                     /product="F-BAR and double SH3 domains protein 2 isoform
                     X4"
                     /calculated_mol_wt=68091
     Region          16..275
                     /region_name="F-BAR_FCHSD2"
                     /note="The F-BAR (FES-CIP4 Homology and
                     Bin/Amphiphysin/Rvs) domain of FCH and double SH3 domains
                     2 (FCHSD2); cd07677"
                     /db_xref="CDD:153361"
     Site            order(21,24,31,34..35,38,41..42,45..46,49,53,56,60,93,96,
                     194,198,223,228,231,234..235,238,242,245,249,253,256..257,
                     260)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:153361"
     Region          471..527
                     /region_name="SH3_FCHSD_1"
                     /note="First Src Homology 3 domain of FCH and double SH3
                     domains proteins; cd11761"
                     /db_xref="CDD:212695"
     Site            order(478,480,483,487,506..507,521,523..524)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212695"
     CDS             1..597
                     /gene="FCHSD2"
                     /gene_synonym="NWK; NWK1; SH3MD3"
                     /coded_by="XM_054370679.1:442..2235"
                     /db_xref="GeneID:9873"
                     /db_xref="HGNC:HGNC:29114"
                     /db_xref="MIM:617556"
ORIGIN      
        1 mqppprkvkv tqelkniqve qmtklqakhq aecdlledmr tfsqkkaaie reyaqgmqkl
       61 asqylkrdwp gvkaddrndy rsmypvwksf legtmqvaqs rmnicenykn fisepartvr
      121 slkeqqlkrc vdqltkiqte lqetvkdlak gkkkyfeteq mahavrekad ieaksklslf
      181 qsrislqkas vklkarrsec nskatharnd ylltlaaana hqdryyqtdl vnimkaldgn
      241 vydhlkdyli afsrteletc qavqntfqfl lensskvvrd ynlqlflqen avfhkpqpfq
      301 fqpcdsdtsr qlesetgtte ehslnkeark watrvarehk nivhqqrvln dlechgaavs
      361 eqsraeleqk idearenirk aeiiklkaea rldllkqigv svdtwlksam nqvmeelene
      421 rwarppavts ngtlhslnad tereegeefe dnmdvfddss sspsgtlrny pltckvvysy
      481 kasqpdelti eehevlevie dgdmedwvka rnkvgqvgyv pekylqfpts nsllsmlqsl
      541 aaldsrshts snsteaelvs gslngdasdl sfpqatrlpa stavvrpasq qplpqpr
//
LOCUS       XP_047301809             355 aa            linear   PRI 05-AUG-2025
DEFINITION  endogenous retrovirus group K member 7 Env polyprotein-like [Homo
            sapiens].
ACCESSION   XP_047301809
VERSION     XP_047301809.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_047445853.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..355
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..355
                     /product="endogenous retrovirus group K member 7 Env
                     polyprotein-like"
                     /calculated_mol_wt=40178
     Region          <1..88
                     /region_name="HERV-K_env_2"
                     /note="Retro-transcribing viruses envelope glycoprotein;
                     pfam13804"
                     /db_xref="CDD:290518"
     CDS             1..355
                     /gene="LOC124902766"
                     /coded_by="XM_047445853.1:84..1151"
                     /db_xref="GeneID:124902766"
ORIGIN      
        1 mvsgmslrpr vnylqdfsyq rslkfrpkgk pcpkeipkes kntevlvwee cvansavilq
       61 nnefgtiidw aprgqfdhnc sgqtqlcpsa qvspavdsdl tesldkhkhk klqslypwew
      121 gekgistprp kiispvsgpe hpelwrliva shhiriwsgn qtsetrdrkp fytidlnssl
      181 tvplqscvkp pymlvvgniv ikpdsqtitc encrlftcid stfnwqqril lvraregvwi
      241 pvsmdrpwea spsihiltev lkgilnrskr fiftliavim gliavtataa vagvalhssv
      301 qsvnfvndwq knsarlwnsq ssidqklanq inhlrqthld rrqthelrts fpvtv
//
LOCUS       XP_047301810             355 aa            linear   PRI 05-AUG-2025
DEFINITION  endogenous retrovirus group K member 7 Env polyprotein-like [Homo
            sapiens].
ACCESSION   XP_047301810
VERSION     XP_047301810.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_047445854.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..355
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..355
                     /product="endogenous retrovirus group K member 7 Env
                     polyprotein-like"
                     /calculated_mol_wt=40178
     Region          <1..88
                     /region_name="HERV-K_env_2"
                     /note="Retro-transcribing viruses envelope glycoprotein;
                     pfam13804"
                     /db_xref="CDD:290518"
     CDS             1..355
                     /gene="LOC124902766"
                     /coded_by="XM_047445854.1:84..1151"
                     /db_xref="GeneID:124902766"
ORIGIN      
        1 mvsgmslrpr vnylqdfsyq rslkfrpkgk pcpkeipkes kntevlvwee cvansavilq
       61 nnefgtiidw aprgqfdhnc sgqtqlcpsa qvspavdsdl tesldkhkhk klqslypwew
      121 gekgistprp kiispvsgpe hpelwrliva shhiriwsgn qtsetrdrkp fytidlnssl
      181 tvplqscvkp pymlvvgniv ikpdsqtitc encrlftcid stfnwqqril lvraregvwi
      241 pvsmdrpwea spsihiltev lkgilnrskr fiftliavim gliavtataa vagvalhssv
      301 qsvnfvndwq knsarlwnsq ssidqklanq inhlrqthld rrqthelrts fpvtv
//
LOCUS       XP_047301813             406 aa            linear   PRI 05-AUG-2025
DEFINITION  WAS protein family homolog 2-like isoform X1 [Homo sapiens].
ACCESSION   XP_047301813
VERSION     XP_047301813.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_047445857.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..406
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..406
                     /product="WAS protein family homolog 2-like isoform X1"
                     /calculated_mol_wt=43322
     Region          28..238
                     /region_name="WASH_WAHD"
                     /note="WAHD domain of WASH complex; pfam11945"
                     /db_xref="CDD:463408"
     CDS             1..406
                     /gene="LOC124906931"
                     /coded_by="XM_047445857.1:47..1267"
                     /db_xref="GeneID:124906931"
ORIGIN      
        1 mgavctsgar sertmtpvrm qhslagqtya vpliqpdlrr eeavqqmada lqylqkvsgd
       61 ifsrsdypcr gpldgtkigp gkisqqveqs rsqvqaigek vslaqakiek ikgskkaikv
      121 fssakypapg rlqeygsift gaqdpglqrr prhriqskhr plderalqvp enyfyvpdlg
      181 qvpeidvpsy lpdlpgiand lmyiadlgpg iapsapgtip elptfhteva eplkadlqdg
      241 vltppppppp pppapevlas applppstaa pvgqgarqdd ssssaspsvq gaprevvdps
      301 ggratllesi rqaggigkak lrsmkerkle kkkqkeqeqv ratsqgghlm sdlfnklvmr
      361 rkgisgkgpg agegpggafa rvsdsipplp ppqqpqaeed eddwes
//
LOCUS       XP_047301814             374 aa            linear   PRI 05-AUG-2025
DEFINITION  WAS protein family homolog 2-like isoform X2 [Homo sapiens].
ACCESSION   XP_047301814
VERSION     XP_047301814.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_047445858.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..374
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..374
                     /product="WAS protein family homolog 2-like isoform X2"
                     /calculated_mol_wt=40072
     Region          14..206
                     /region_name="WASH_WAHD"
                     /note="WAHD domain of WASH complex; pfam11945"
                     /db_xref="CDD:463408"
     CDS             1..374
                     /gene="LOC124906931"
                     /coded_by="XM_047445858.1:39..1163"
                     /db_xref="GeneID:124906931"
ORIGIN      
        1 mtpvrmqhsl agqtyavpli qpdlrreeav qqmadalqyl qkvsgdifsr isqqveqsrs
       61 qvqaigekvs laqakiekik gskkaikvfs sakypapgrl qeygsiftga qdpglqrrpr
      121 hriqskhrpl deralqvpen yfyvpdlgqv peidvpsylp dlpgiandlm yiadlgpgia
      181 psapgtipel ptfhtevaep lkadlqdgvl tppppppppp papevlasap plppstaapv
      241 gqgarqddss ssaspsvqga prevvdpsgg ratllesirq aggigkaklr smkerklekk
      301 kqkeqeqvra tsqgghlmsd lfnklvmrrk gisgkgpgag egpggafarv sdsipplppp
      361 qqpqaeeded dwes
//
LOCUS       XP_047301815             368 aa            linear   PRI 05-AUG-2025
DEFINITION  WAS protein family homolog 2-like isoform X3 [Homo sapiens].
ACCESSION   XP_047301815
VERSION     XP_047301815.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_047445859.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..368
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..368
                     /product="WAS protein family homolog 2-like isoform X3"
                     /calculated_mol_wt=38850
     Region          <130..200
                     /region_name="WASH_WAHD"
                     /note="WAHD domain of WASH complex; pfam11945"
                     /db_xref="CDD:463408"
     CDS             1..368
                     /gene="LOC124906931"
                     /coded_by="XM_047445859.1:4148..5254"
                     /db_xref="GeneID:124906931"
ORIGIN      
        1 mpcpsssqtc gerrpssrwr mpcstcrrsl etssagvlqc qvpcsrapag iwlhlhgrpg
       61 pwpaetpppq dpeqapppgr agpageaegl scvrehqaga rgrcrrgtwg ssqqhqlcql
      121 laalqhhrep vpenyfyvpd lgqvpeidvp sylpdlpgia ndlmyiadlg pgiapsapgt
      181 ipelptfhte vaeplkadlq dgvltppppp pppppapevl asapplppst aapvgqgarq
      241 ddssssasps vqgaprevvd psggratlle sirqaggigk aklrsmkerk lekkkqkeqe
      301 qvratsqggh lmsdlfnklv mrrkgisgkg pgagegpgga farvsdsipp lpppqqpqae
      361 ededdwes
//
LOCUS       XP_047301816             360 aa            linear   PRI 05-AUG-2025
DEFINITION  WAS protein family homolog 6-like isoform X4 [Homo sapiens].
ACCESSION   XP_047301816
VERSION     XP_047301816.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_047445860.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..360
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..360
                     /product="WAS protein family homolog 6-like isoform X4"
                     /calculated_mol_wt=38192
     Region          40..192
                     /region_name="WASH_WAHD"
                     /note="WAHD domain of WASH complex; pfam11945"
                     /db_xref="CDD:463408"
     CDS             1..360
                     /gene="LOC124906931"
                     /coded_by="XM_047445860.1:4414..5496"
                     /db_xref="GeneID:124906931"
ORIGIN      
        1 msgemafhem qahknalgts geqqaaditg ptphqggwkq veqsrsqvqa igekvslaqa
       61 kiekikgskk aikvfssaky papgrlqeyg siftgaqdpg lqrrprhriq skhrpldera
      121 lqvpenyfyv pdlgqvpeid vpsylpdlpg iandlmyiad lgpgiapsap gtipelptfh
      181 tevaeplkad lqdgvltppp pppppppape vlasapplpp staapvgqga rqddssssas
      241 psvqgaprev vdpsggratl lesirqaggi gkaklrsmke rklekkkqke qeqvratsqg
      301 ghlmsdlfnk lvmrrkgisg kgpgagegpg gafarvsdsi pplpppqqpq aeededdwes
//
LOCUS       XP_047301817             274 aa            linear   PRI 05-AUG-2025
DEFINITION  WASH complex subunit 1-like isoform X5 [Homo sapiens].
ACCESSION   XP_047301817
VERSION     XP_047301817.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_047445861.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..274
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..274
                     /product="WASH complex subunit 1-like isoform X5"
                     /calculated_mol_wt=29941
     Region          28..>214
                     /region_name="WASH_WAHD"
                     /note="WAHD domain of WASH complex; pfam11945"
                     /db_xref="CDD:463408"
     CDS             1..274
                     /gene="LOC124906931"
                     /coded_by="XM_047445861.1:47..871"
                     /db_xref="GeneID:124906931"
ORIGIN      
        1 mgavctsgar sertmtpvrm qhslagqtya vpliqpdlrr eeavqqmada lqylqkvsgd
       61 ifsrsdypcr gpldgtkigp gkisqqveqs rsqvqaigek vslaqakiek ikgskkaikv
      121 fssakypapg rlqeygsift gaqdpglqrr prhriqskhr plderalqek lkdfpvcvst
      181 kpepeddaee glgglpsnis svsslllfnt tenlsqrtts mcqtwarclr lmfhptcltc
      241 palpttsctl ptwapalppl plapfqncpp stlr
//
LOCUS       XP_047301818             264 aa            linear   PRI 05-AUG-2025
DEFINITION  WAS protein family homolog 2-like isoform X6 [Homo sapiens].
ACCESSION   XP_047301818
VERSION     XP_047301818.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_047445862.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..264
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..264
                     /product="WAS protein family homolog 2-like isoform X6"
                     /calculated_mol_wt=27755
     Region          <1..96
                     /region_name="WASH_WAHD"
                     /note="WAHD domain of WASH complex; pfam11945"
                     /db_xref="CDD:463408"
     CDS             1..264
                     /gene="LOC124906931"
                     /coded_by="XM_047445862.1:171..965"
                     /db_xref="GeneID:124906931"
ORIGIN      
        1 mlgaeteekl fdaplsiskr eqleqqvpen yfyvpdlgqv peidvpsylp dlpgiandlm
       61 yiadlgpgia psapgtipel ptfhtevaep lkadlqdgvl tppppppppp papevlasap
      121 plppstaapv gqgarqddss ssaspsvqga prevvdpsgg ratllesirq aggigkaklr
      181 smkerklekk kqkeqeqvra tsqgghlmsd lfnklvmrrk gisgkgpgag egpggafarv
      241 sdsipplppp qqpqaeeded dwes
//
LOCUS       XP_047301819             264 aa            linear   PRI 05-AUG-2025
DEFINITION  WAS protein family homolog 2-like isoform X6 [Homo sapiens].
ACCESSION   XP_047301819
VERSION     XP_047301819.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_047445863.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..264
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..264
                     /product="WAS protein family homolog 2-like isoform X6"
                     /calculated_mol_wt=27755
     Region          <1..96
                     /region_name="WASH_WAHD"
                     /note="WAHD domain of WASH complex; pfam11945"
                     /db_xref="CDD:463408"
     CDS             1..264
                     /gene="LOC124906931"
                     /coded_by="XM_047445863.1:141..935"
                     /db_xref="GeneID:124906931"
ORIGIN      
        1 mlgaeteekl fdaplsiskr eqleqqvpen yfyvpdlgqv peidvpsylp dlpgiandlm
       61 yiadlgpgia psapgtipel ptfhtevaep lkadlqdgvl tppppppppp papevlasap
      121 plppstaapv gqgarqddss ssaspsvqga prevvdpsgg ratllesirq aggigkaklr
      181 smkerklekk kqkeqeqvra tsqgghlmsd lfnklvmrrk gisgkgpgag egpggafarv
      241 sdsipplppp qqpqaeeded dwes
//
LOCUS       XP_047301820             249 aa            linear   PRI 05-AUG-2025
DEFINITION  WASH complex subunit 1 isoform X7 [Homo sapiens].
ACCESSION   XP_047301820
VERSION     XP_047301820.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_047445864.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..249
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..249
                     /product="WASH complex subunit 1 isoform X7"
                     /calculated_mol_wt=27272
     Region          28..237
                     /region_name="WASH_WAHD"
                     /note="WAHD domain of WASH complex; pfam11945"
                     /db_xref="CDD:463408"
     CDS             1..249
                     /gene="LOC124906931"
                     /coded_by="XM_047445864.1:47..796"
                     /db_xref="GeneID:124906931"
ORIGIN      
        1 mgavctsgar sertmtpvrm qhslagqtya vpliqpdlrr eeavqqmada lqylqkvsgd
       61 ifsrsdypcr gpldgtkigp gkisqqveqs rsqvqaigek vslaqakiek ikgskkaikv
      121 fssakypapg rlqeygsift gaqdpglqrr prhriqskhr plderalqvp enyfyvpdlg
      181 qvpeidvpsy lpdlpgiand lmyiadlgpg iapsapgtip elptfhteva eplkadtphf
      241 vfqtykmgy
//
LOCUS       XP_047301821             240 aa            linear   PRI 05-AUG-2025
DEFINITION  WASH complex subunit 1 isoform X8 [Homo sapiens].
ACCESSION   XP_047301821
VERSION     XP_047301821.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_047445865.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..240
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..240
                     /product="WASH complex subunit 1 isoform X8"
                     /calculated_mol_wt=26229
     Region          28..232
                     /region_name="WASH_WAHD"
                     /note="WAHD domain of WASH complex; pfam11945"
                     /db_xref="CDD:463408"
     CDS             1..240
                     /gene="LOC124906931"
                     /coded_by="XM_047445865.1:47..769"
                     /db_xref="GeneID:124906931"
ORIGIN      
        1 mgavctsgar sertmtpvrm qhslagqtya vpliqpdlrr eeavqqmada lqylqkvsgd
       61 ifsrsdypcr gpldgtkigp gkisqqveqs rsqvqaigek vslaqakiek ikgskkaikv
      121 fssakypapg rlqeygsift gaqdpglqrr prhriqskhr plderalqvp enyfyvpdlg
      181 qvpeidvpsy lpdlpgiand lmyiadlgpg iapsapgtip elptfhteva eplktykmgy
//
LOCUS       XP_047301822             231 aa            linear   PRI 05-AUG-2025
DEFINITION  WASH complex subunit 1-like isoform X9 [Homo sapiens].
ACCESSION   XP_047301822
VERSION     XP_047301822.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_047445866.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..231
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..231
                     /product="WASH complex subunit 1-like isoform X9"
                     /calculated_mol_wt=24981
     Region          28..>215
                     /region_name="WASH_WAHD"
                     /note="WAHD domain of WASH complex; pfam11945"
                     /db_xref="CDD:463408"
     CDS             1..231
                     /gene="LOC124906931"
                     /coded_by="XM_047445866.1:47..742"
                     /db_xref="GeneID:124906931"
ORIGIN      
        1 mgavctsgar sertmtpvrm qhslagqtya vpliqpdlrr eeavqqmada lqylqkvsgd
       61 ifsrsdypcr gpldgtkigp gkisqqveqs rsqvqaigek vslaqakiek ikgskkaikv
      121 fssakypapg rlqeygsift gaqdpglqrr prhriqskhr plderalqek lkdfpvcvst
      181 kpepeddaee glgglpsnis svsslllfnt tenlygqrag prgvggrpgl a
//
LOCUS       XP_047301823             214 aa            linear   PRI 05-AUG-2025
DEFINITION  WASH complex subunit 1-like isoform X10 [Homo sapiens].
ACCESSION   XP_047301823
VERSION     XP_047301823.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_047445867.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..214
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..214
                     /product="WASH complex subunit 1-like isoform X10"
                     /calculated_mol_wt=23331
     Region          28..>214
                     /region_name="WASH_WAHD"
                     /note="WAHD domain of WASH complex; pfam11945"
                     /db_xref="CDD:463408"
     CDS             1..214
                     /gene="LOC124906931"
                     /coded_by="XM_047445867.1:47..691"
                     /db_xref="GeneID:124906931"
ORIGIN      
        1 mgavctsgar sertmtpvrm qhslagqtya vpliqpdlrr eeavqqmada lqylqkvsgd
       61 ifsrsdypcr gpldgtkigp gkisqqveqs rsqvqaigek vslaqakiek ikgskkaikv
      121 fssakypapg rlqeygsift gaqdpglqrr prhriqskhr plderalqek lkdfpvcvst
      181 kpepeddaee glgglpsnis svsslllfnt tenl
//
LOCUS       XP_047301824             213 aa            linear   PRI 05-AUG-2025
DEFINITION  WASH complex subunit 1-like isoform X11 [Homo sapiens].
ACCESSION   XP_047301824
VERSION     XP_047301824.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_047445868.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..213
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..213
                     /product="WASH complex subunit 1-like isoform X11"
                     /calculated_mol_wt=23138
     Region          28..>197
                     /region_name="WASH_WAHD"
                     /note="WAHD domain of WASH complex; pfam11945"
                     /db_xref="CDD:463408"
     CDS             1..213
                     /gene="LOC124906931"
                     /coded_by="XM_047445868.1:47..688"
                     /db_xref="GeneID:124906931"
ORIGIN      
        1 mgavctsgar sertmtpvrm qhslagqtya vpliqpdlrr eeavqqmada lqylqkvsgd
       61 ifsrisqqve qsrsqvqaig ekvslaqaki ekikgskkai kvfssakypa pgrlqeygsi
      121 ftgaqdpglq rrprhriqsk hrplderalq eklkdfpvcv stkpepedda eeglgglpsn
      181 issvsslllf nttenlygqr agprgvggrp gla
//
LOCUS       XP_047301829             455 aa            linear   PRI 05-AUG-2025
DEFINITION  collagen alpha-2(IV) chain-like [Homo sapiens].
ACCESSION   XP_047301829
VERSION     XP_047301829.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_047445873.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..455
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..455
                     /product="collagen alpha-2(IV) chain-like"
                     /calculated_mol_wt=49523
     CDS             1..455
                     /gene="LOC124906938"
                     /coded_by="XM_047445873.1:1868..3235"
                     /db_xref="GeneID:124906938"
ORIGIN      
        1 mgklvtrrll grrgsvafpg qkgkcgvpwr egrvwrpler rasvaspgqk gecgvpwreg
       61 pvwrplerrg svaspgekge cgvpwreggv wrplerrgsv aspgekgecg vpwreggvwr
      121 plerrgsvas pgekgecgvp wreggvwrpl errasvaspg qkgecgvpwr egpvwrpler
      181 rasvaspgek gecgvpwreg gvwrplerrg svaspgekge cgvpwteggv wrplerrasv
      241 aspgekgecg vpwteggvwr plerrgsvas pgekgqcgvp wteggvwrpl errasvaspg
      301 qkgecgvpwr egrvwrpler rasvaspgqk gecgvpwreg pvwrplerrg svaspgekge
      361 cgvpwreggv wrplerrgsv aspgekgecg vpwreggvwr pldrrgsvas pgekgecgvr
      421 wregrvwysl drrgsvpaal asqrhallal pqpqg
//
LOCUS       XP_054226655             172 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein LOC124900301 [Homo sapiens].
ACCESSION   XP_054226655
VERSION     XP_054226655.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370680.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..172
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..172
                     /product="uncharacterized protein LOC124900301"
                     /calculated_mol_wt=18178
     CDS             1..172
                     /gene="LOC124900301"
                     /coded_by="XM_054370680.1:2165..2683"
                     /db_xref="GeneID:124900301"
ORIGIN      
        1 mppgkgprlg gngvtdvgpw phcgvsrvvp igppaspsha teppssaivq lrvkswrgah
       61 rlpldrgvrt rltvsapaeq gwvlsisssa rasgnslepg vlplfgdret hsvggsqdms
      121 savkrfcsvs clqnlhvles kdgwergrsw rclpfgagpc hrtshhpccl gw
//
LOCUS       XP_047301830             215 aa            linear   PRI 05-AUG-2025
DEFINITION  proapoptotic nucleolar protein 1 [Homo sapiens].
ACCESSION   XP_047301830
VERSION     XP_047301830.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_047445874.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..215
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..215
                     /product="proapoptotic nucleolar protein 1"
                     /calculated_mol_wt=22711
     CDS             1..215
                     /gene="PANO1"
                     /coded_by="XM_047445874.1:1..648"
                     /db_xref="GeneID:101927423"
                     /db_xref="HGNC:HGNC:51237"
                     /db_xref="MIM:620541"
ORIGIN      
        1 mgvrlrvwpa aphsisrcpr plgavlsill aggsrkgtpt arclgqrtke krvggrslrs
       61 eagsgpcpta gaqptapssa wpprlrprtc pqmsgelprv rptrvglssl gsgpghppsg
      121 trmcgerarn rrgrarrltp eqprigasag pgpplpparp rcsgschlpr ppqhlsppqp
      181 grvrmgaaeg srradthhar rrrrarlpap rsast
//
LOCUS       XP_054226656             365 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein LOC124902605 [Homo sapiens].
ACCESSION   XP_054226656
VERSION     XP_054226656.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370681.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..365
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..365
                     /product="uncharacterized protein LOC124902605"
                     /calculated_mol_wt=40010
     CDS             1..365
                     /gene="LOC124902605"
                     /coded_by="XM_054370681.1:2195..3292"
                     /db_xref="GeneID:124902605"
ORIGIN      
        1 mhnsnlnhkn tsnvpnkgrf ythlprapqk cqgvkdmeac rrresqcglw yvhdghrsap
       61 tvtqqpcqag prgprgrwdv agwglctalq hkcpadsrgs nlvpswchsp gtgprlprrp
      121 stdrtgtgrq lsrrpsqfse cglavpahgf vhgldstpls itpppmllpt aglipcsgsa
      181 prssglierg tapedqlwrr pggplkgraq prrtdqvlai hvrcrfsvam vsrnhgwesr
      241 pqslshqppa htatvhsslk vplpqggalp pgsrcwpcgv rrrdcpqgpl fplnrqrece
      301 lavrragpgi lsvegtpdcc gertrprvqp rpelrpgdqq slhnnnasfc kcilffyciy
      361 lscpm
//
LOCUS       XP_054226657             201 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein LOC124902608 [Homo sapiens].
ACCESSION   XP_054226657
VERSION     XP_054226657.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370682.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..201
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..201
                     /product="uncharacterized protein LOC124902608"
                     /calculated_mol_wt=21353
     CDS             1..201
                     /gene="LOC124902608"
                     /coded_by="XM_054370682.1:1..606"
                     /db_xref="GeneID:124902608"
ORIGIN      
        1 mpqaelgiqv ctcrlrgsvs rccshrefrr qpspcaagig llhlgstasr qvkpprlppp
       61 pwgrsgeklp ftpfpgcsls rwhaspqtqv afgprwvsll plphtpsghw dpcpsdvlgs
      121 rsgashcgkr pgawperqpr aglspeswsr areapipprp aalsavssic ssfhpqlysg
      181 lgplvgppsp fplplvpsag r
//
LOCUS       XP_047301831             221 aa            linear   PRI 05-AUG-2025
DEFINITION  keratin-associated protein 5-5 isoform X1 [Homo sapiens].
ACCESSION   XP_047301831
VERSION     XP_047301831.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_047445875.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..221
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..221
                     /product="keratin-associated protein 5-5 isoform X1"
                     /calculated_mol_wt=19697
     CDS             1..221
                     /gene="KRTAP5-5"
                     /coded_by="XM_047445875.1:2784..3449"
                     /db_xref="GeneID:439915"
                     /db_xref="HGNC:HGNC:23601"
ORIGIN      
        1 mgccgcsggc gsgcgglgsg cggcgsgcgg rgsgcggcgs gcggcgsgcg gcgsgcggcg
       61 gcgsgccvpv ccckpmcccv pacscsscgk ggcgscggsk rgcvscgvsk gacgscggsk
      121 ggcgscggsk ggcgscggsk ggcgsygcsq cscckpcccs sgcgssccqs scckpyccqs
      181 scckpcscfs gcgssccqss cykpcccqss ccvpvccqck i
//
LOCUS       XP_047301832             306 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein LOC124906943 [Homo sapiens].
ACCESSION   XP_047301832
VERSION     XP_047301832.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_047445876.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..306
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..306
                     /product="uncharacterized protein LOC124906943"
                     /calculated_mol_wt=32885
     CDS             1..306
                     /gene="LOC124906943"
                     /coded_by="XM_047445876.1:15720..16640"
                     /db_xref="GeneID:124906943"
ORIGIN      
        1 mcpgpnpryl wmwpclesgs vqmllkilsp rkpgqnragp wqapvcvpcp dlpvldtawa
       61 wkrtrcglwy lasltwcisa ahlcrrmcec rascllkaec ssirctdvih vypfthvdvw
      121 lcplsdgpep ccweracadh lgacacfswv crvrafsptv qppmgpwsrs lvhalgctcl
      181 lcpaphlppl ppphlpplpp sapassarlc tcllcpalhl pplppsapas sarlctcllc
      241 pplhlpplpr sapassappr tcllcpplhl pplpcsagsr tvqtqmlgpk glcshtptpc
      301 avrcpg
//
LOCUS       XP_047301838             280 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein LOC105369591 isoform X1 [Homo sapiens].
ACCESSION   XP_047301838
VERSION     XP_047301838.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_047445882.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..280
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..280
                     /product="uncharacterized protein LOC105369591 isoform X1"
                     /calculated_mol_wt=30302
     CDS             1..280
                     /gene="LOC105369591"
                     /coded_by="XM_047445882.1:342..1184"
                     /db_xref="GeneID:105369591"
ORIGIN      
        1 mrsrhflrgr vrsgvtlflp spprlhtalg cesliqkghe vrqrcrtvmg leehaggmra
       61 iwvtargssa ahsfsspgpr dgfhlghlpl erlllakstp petdgegdss vvpvlglafc
      121 llpptaqver ggpcpyrles irlsgqcssa fsstreaavc edssfcgrrk sretttlwvv
      181 lrslvcwlsp tqaqfallic yvflgqllws lvhpehssvp fqgslpgspp trecglgika
      241 wraasychlp qslitlayls plsvlgmgsh cgslfpftkv
//
LOCUS       XP_047301839             274 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein LOC105369591 isoform X2 [Homo sapiens].
ACCESSION   XP_047301839
VERSION     XP_047301839.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_047445883.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..274
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..274
                     /product="uncharacterized protein LOC105369591 isoform X2"
                     /calculated_mol_wt=29657
     CDS             1..274
                     /gene="LOC105369591"
                     /coded_by="XM_047445883.1:342..1166"
                     /db_xref="GeneID:105369591"
ORIGIN      
        1 mrsrhflrgr vrsgvtlflp spprlhtalg cesliqkghe vrqrcrtvmg leehaggmra
       61 iwvtargssa ahsfsspgpr dgfhlghlpl erlllakstp petdgegdss vvpvlglafc
      121 llpptaqver ggpcpyrles issafsstre aavcedssfc grrksrettt lwvvlrslvc
      181 wlsptqaqfa llicyvflgq llwslvhpeh ssvpfqgslp gspptrecgl gikawraasy
      241 chlpqslitl aylsplsvlg mgshcgslfp ftkv
//
LOCUS       XP_047301841              58 aa            linear   PRI 05-AUG-2025
DEFINITION  ATP synthase subunit ATP5MJ, mitochondrial-like [Homo sapiens].
ACCESSION   XP_047301841
VERSION     XP_047301841.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_047445885.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..58
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..58
                     /product="ATP synthase subunit ATP5MJ, mitochondrial-like"
                     /calculated_mol_wt=6626
     Region          1..58
                     /region_name="Mit_proteolip"
                     /note="Mitochondrial proteolipid; pfam08039"
                     /db_xref="CDD:429796"
     CDS             1..58
                     /gene="LOC112268080"
                     /coded_by="XM_047445885.1:911..1087"
                     /db_xref="GeneID:112268080"
ORIGIN      
        1 mlqsiiknvw ipmklyytqv yqdiwvgmgl msliiykiqs ankrskalks pvpahshh
//
LOCUS       XP_047301842             202 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein LOC124906954 [Homo sapiens].
ACCESSION   XP_047301842
VERSION     XP_047301842.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_047445886.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..202
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..202
                     /product="uncharacterized protein LOC124906954"
                     /calculated_mol_wt=21255
     CDS             1..202
                     /gene="LOC124906954"
                     /coded_by="XM_047445886.1:390..998"
                     /db_xref="GeneID:124906954"
ORIGIN      
        1 mmaaagsler lqqggtaeat hsmervgaed rwescpfrvg agaplvplqs pkpwlwslas
       61 lcspsgnrre pqlprrscss snprlqtwvs rsteqagalp sphscscpnr gcgprqscil
      121 gglgrpplll qawkcllplp gfsllsapap iqeqsqaepg rcrsparcah aqgtadtpap
      181 crpgpfwiwg adtsvegkls gg
//
LOCUS       XP_047301843             208 aa            linear   PRI 05-AUG-2025
DEFINITION  peptidyl-prolyl cis-trans isomerase A-like [Homo sapiens].
ACCESSION   XP_047301843
VERSION     XP_047301843.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_047445887.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 20% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..208
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..208
                     /product="peptidyl-prolyl cis-trans isomerase A-like"
                     /calculated_mol_wt=22119
     Region          39..197
                     /region_name="cyclophilin_ABH_like"
                     /note="Cyclophilin A, B and H-like cyclophilin-type
                     peptidylprolyl cis- trans isomerase (PPIase) domain. This
                     family represents the archetypal cystolic cyclophilin
                     similar to human cyclophilins A, B and H. PPIase is an
                     enzyme which accelerates protein folding...; cd01926"
                     /db_xref="CDD:238907"
     Site            order(89..90,95,146,148,156)
                     /site_type="active"
                     /db_xref="CDD:238907"
     CDS             1..208
                     /gene="PPIAP40"
                     /coded_by="XM_047445887.1:1..627"
                     /db_xref="GeneID:107984349"
                     /db_xref="HGNC:HGNC:53664"
ORIGIN      
        1 mhqallpvgy fgcvlvskvi hsldaaaags pvlsavvnpt vffdiavnse plghvsfklf
       61 adkfpktaen fralstgekg fgykgscfhr iipgfmcqgg dfthhngtss ksiygekfdd
      121 anfilkhtgp gilsmanagp ntnssqffic taktewldgk havfgkakeg mniveaiehf
      181 gsrngknskk ittadcgqll isltcvls
//
LOCUS       XP_047301845             506 aa            linear   PRI 05-AUG-2025
DEFINITION  basic salivary proline-rich protein 2 [Homo sapiens].
ACCESSION   XP_047301845
VERSION     XP_047301845.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_047445889.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 48% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..506
                     /product="basic salivary proline-rich protein 2"
                     /calculated_mol_wt=53018
     Region          <208..396
                     /region_name="PRK12323"
                     /note="DNA polymerase III subunit gamma/tau; cl46901"
                     /db_xref="CDD:481241"
     CDS             1..506
                     /gene="LOC124902806"
                     /coded_by="XM_047445889.1:1..1521"
                     /db_xref="GeneID:124902806"
ORIGIN      
        1 mlplkhsqka ralltkpqpf kqgsmtpnsi ssnisqqqgi qsesctlssk egkeqqqalr
       61 phlrvprkla laealhldtr cvhqriawad rpkasatslg slvhaaapra eqgwdaphrt
      121 qgphlpahlq ghagtcrsad cpripgrvgw rfaanpqefc ppprllasgv gegspssslg
      181 hapgltetlt htspcfvalg alhslgnapd gdpnpdraas pgcgespltw speasdgpla
      241 hrptagpsar ptsgptaaag agahvtgrgp aegssrsaap pprdlpqgpp pwapapsrap
      301 kkpagtrppg flfpgdrpgq prpfepassp ppgprvrapa pplsadrapf reprpvrras
      361 ssaqlrlrgg pggypalrlp vswaspvlqr rspvtgnese eegngvence erkhrkptle
      421 alpeqkpfga srlprpacnp gkievvsepp slsrsespri ipgpaalhsq pgvevplvvg
      481 tkqkfclmks rgqeafpcaq rqglgp
//
LOCUS       XP_047301846              82 aa            linear   PRI 05-AUG-2025
DEFINITION  cytochrome c oxidase subunit NDUFA4-like [Homo sapiens].
ACCESSION   XP_047301846
VERSION     XP_047301846.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_047445890.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..82
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..82
                     /product="cytochrome c oxidase subunit NDUFA4-like"
                     /calculated_mol_wt=9056
     Region          11..78
                     /region_name="B12D"
                     /note="NADH-ubiquinone reductase complex 1 MLRQ subunit;
                     pfam06522"
                     /db_xref="CDD:461937"
     CDS             1..82
                     /gene="LOC107984365"
                     /coded_by="XM_047445890.1:24..272"
                     /db_xref="GeneID:107984365"
ORIGIN      
        1 mphqtlsqtk knpsliscfi figagstgaa wyvlclasfs pdvswarnnn pepwnklspn
       61 dqyksysvnv dysklkkegp df
//
LOCUS       XP_047301850             545 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein LOC124902693 [Homo sapiens].
ACCESSION   XP_047301850
VERSION     XP_047301850.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_047445894.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..545
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..545
                     /product="uncharacterized protein LOC124902693"
                     /calculated_mol_wt=60207
     Region          <262..>513
                     /region_name="PRK02224"
                     /note="DNA double-strand break repair Rad50 ATPase"
                     /db_xref="CDD:179385"
     CDS             1..545
                     /gene="LOC124902693"
                     /coded_by="XM_047445894.1:289..1926"
                     /db_xref="GeneID:124902693"
ORIGIN      
        1 mwvvdqgrgq gtmsvekggl frfplldgre rrgkqprrtr elhksrgqga pseagvrers
       61 plergckgvp mlrektwgpw nglmvigkrv elltrntrkp kleseywrle dvektvlkgk
      121 sgpsqermdv kllyrgasas qasadlgkds prgiwgkqev kheikaksks agmtagpmkg
      181 sgfeerlrsa gekvgtsged lrsngyklgq dekglrssvd kmrssveklr stseklvcrg
      241 ekqgssgvkl rssgrklrss genlrssrek lrwsgeklgt sgeklrssge klgtsdeklr
      301 lsgetlrsir eklrlsgekl gtsdeklrls geklrlsgek lrssreklrl sgeklgtsde
      361 klrlsgeklr ssreklrlsg eklrssrekl rlsgeklgts deklrlsgek lrssreklgt
      421 sgeklrssre klrlsgeklg ssaeklrsse eklgtsgekl egsrmgsine kniekvvevt
      481 gdervmafth demeipfesv kgseelqgte kgvgveggil sevkditdes vsmekkdiig
      541 egtse
//
LOCUS       XP_047301851             545 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein LOC124902693 [Homo sapiens].
ACCESSION   XP_047301851
VERSION     XP_047301851.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_047445895.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..545
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..545
                     /product="uncharacterized protein LOC124902693"
                     /calculated_mol_wt=60207
     Region          <262..>513
                     /region_name="PRK02224"
                     /note="DNA double-strand break repair Rad50 ATPase"
                     /db_xref="CDD:179385"
     CDS             1..545
                     /gene="LOC124902693"
                     /coded_by="XM_047445895.1:289..1926"
                     /db_xref="GeneID:124902693"
ORIGIN      
        1 mwvvdqgrgq gtmsvekggl frfplldgre rrgkqprrtr elhksrgqga pseagvrers
       61 plergckgvp mlrektwgpw nglmvigkrv elltrntrkp kleseywrle dvektvlkgk
      121 sgpsqermdv kllyrgasas qasadlgkds prgiwgkqev kheikaksks agmtagpmkg
      181 sgfeerlrsa gekvgtsged lrsngyklgq dekglrssvd kmrssveklr stseklvcrg
      241 ekqgssgvkl rssgrklrss genlrssrek lrwsgeklgt sgeklrssge klgtsdeklr
      301 lsgetlrsir eklrlsgekl gtsdeklrls geklrlsgek lrssreklrl sgeklgtsde
      361 klrlsgeklr ssreklrlsg eklrssrekl rlsgeklgts deklrlsgek lrssreklgt
      421 sgeklrssre klrlsgeklg ssaeklrsse eklgtsgekl egsrmgsine kniekvvevt
      481 gdervmafth demeipfesv kgseelqgte kgvgveggil sevkditdes vsmekkdiig
      541 egtse
//
LOCUS       XP_047301852             545 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein LOC124902693 [Homo sapiens].
ACCESSION   XP_047301852
VERSION     XP_047301852.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_047445896.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..545
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..545
                     /product="uncharacterized protein LOC124902693"
                     /calculated_mol_wt=60207
     Region          <262..>513
                     /region_name="PRK02224"
                     /note="DNA double-strand break repair Rad50 ATPase"
                     /db_xref="CDD:179385"
     CDS             1..545
                     /gene="LOC124902693"
                     /coded_by="XM_047445896.1:289..1926"
                     /db_xref="GeneID:124902693"
ORIGIN      
        1 mwvvdqgrgq gtmsvekggl frfplldgre rrgkqprrtr elhksrgqga pseagvrers
       61 plergckgvp mlrektwgpw nglmvigkrv elltrntrkp kleseywrle dvektvlkgk
      121 sgpsqermdv kllyrgasas qasadlgkds prgiwgkqev kheikaksks agmtagpmkg
      181 sgfeerlrsa gekvgtsged lrsngyklgq dekglrssvd kmrssveklr stseklvcrg
      241 ekqgssgvkl rssgrklrss genlrssrek lrwsgeklgt sgeklrssge klgtsdeklr
      301 lsgetlrsir eklrlsgekl gtsdeklrls geklrlsgek lrssreklrl sgeklgtsde
      361 klrlsgeklr ssreklrlsg eklrssrekl rlsgeklgts deklrlsgek lrssreklgt
      421 sgeklrssre klrlsgeklg ssaeklrsse eklgtsgekl egsrmgsine kniekvvevt
      481 gdervmafth demeipfesv kgseelqgte kgvgveggil sevkditdes vsmekkdiig
      541 egtse
//
LOCUS       XP_054226661             545 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein LOC124902693 [Homo sapiens].
ACCESSION   XP_054226661
VERSION     XP_054226661.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370686.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..545
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..545
                     /product="uncharacterized protein LOC124902693"
                     /calculated_mol_wt=60207
     Region          <262..>513
                     /region_name="PRK02224"
                     /note="DNA double-strand break repair Rad50 ATPase"
                     /db_xref="CDD:179385"
     CDS             1..545
                     /gene="LOC124902693"
                     /coded_by="XM_054370686.1:289..1926"
                     /db_xref="GeneID:124902693"
ORIGIN      
        1 mwvvdqgrgq gtmsvekggl frfplldgre rrgkqprrtr elhksrgqga pseagvrers
       61 plergckgvp mlrektwgpw nglmvigkrv elltrntrkp kleseywrle dvektvlkgk
      121 sgpsqermdv kllyrgasas qasadlgkds prgiwgkqev kheikaksks agmtagpmkg
      181 sgfeerlrsa gekvgtsged lrsngyklgq dekglrssvd kmrssveklr stseklvcrg
      241 ekqgssgvkl rssgrklrss genlrssrek lrwsgeklgt sgeklrssge klgtsdeklr
      301 lsgetlrsir eklrlsgekl gtsdeklrls geklrlsgek lrssreklrl sgeklgtsde
      361 klrlsgeklr ssreklrlsg eklrssrekl rlsgeklgts deklrlsgek lrssreklgt
      421 sgeklrssre klrlsgeklg ssaeklrsse eklgtsgekl egsrmgsine kniekvvevt
      481 gdervmafth demeipfesv kgseelqgte kgvgveggil sevkditdes vsmekkdiig
      541 egtse
//
LOCUS       XP_047301854             103 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein LOC124902694 [Homo sapiens].
ACCESSION   XP_047301854
VERSION     XP_047301854.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_047445898.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..103
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..103
                     /product="uncharacterized protein LOC124902694"
                     /calculated_mol_wt=10775
     CDS             1..103
                     /gene="LOC124902694"
                     /coded_by="XM_047445898.1:60..371"
                     /db_xref="GeneID:124902694"
ORIGIN      
        1 mprglsvwsc sggrtrsskp epkgarswdp sllvpppple lpgpqlctap alqpspgcap
       61 gsprghftll cshthtldpg htrgkdptgs dftnleqgre akf
//
LOCUS       XP_047301857             234 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein LOC124902704 [Homo sapiens].
ACCESSION   XP_047301857
VERSION     XP_047301857.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_047445901.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..234
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..234
                     /product="uncharacterized protein LOC124902704"
                     /calculated_mol_wt=24765
     CDS             1..234
                     /gene="LOC124902704"
                     /coded_by="XM_047445901.1:1..705"
                     /db_xref="GeneID:124902704"
ORIGIN      
        1 mqgsrrdcrm hatatgpgfs glpwavhhpl hspshcypts avrsprahsa qppssvpsgp
       61 ftpcdnsrcc lgswgtpdps shgissrhag qagpmalhls paawgcpvga dttslpfgpl
      121 prthcmpgwg dggreksgrf pswrgsarag rcpgmtipds qnhlpavgwg spqrahpysq
      181 srdegscgpr rwakrrtgsw mqsgvsgapg qrhraywgqg wgemglsprd lgrs
//
LOCUS       XP_047301859             160 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein LOC124902713 [Homo sapiens].
ACCESSION   XP_047301859
VERSION     XP_047301859.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_047445903.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..160
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..160
                     /product="uncharacterized protein LOC124902713"
                     /calculated_mol_wt=16547
     CDS             1..160
                     /gene="LOC124902713"
                     /coded_by="XM_047445903.1:2758..3240"
                     /db_xref="GeneID:124902713"
ORIGIN      
        1 mcgasgqhpm rckhqgiqli phsplgpgld wvcggcvcvc vcvcvcvcvf vhlsihpsih
       61 psihpgihsf ympnvgqaqg tqrgepsgsp qsgrgsrsrh nestletgti tdgsqvlwvp
      121 qggiasgglg ktsqlrlgaq vgvhlvlive vvarcsgsrl
//
LOCUS       XP_047301862             403 aa            linear   PRI 05-AUG-2025
DEFINITION  potassium/sodium hyperpolarization-activated cyclic
            nucleotide-gated channel 4-like [Homo sapiens].
ACCESSION   XP_047301862
VERSION     XP_047301862.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_047445906.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 46% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..403
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..403
                     /product="potassium/sodium hyperpolarization-activated
                     cyclic nucleotide-gated channel 4-like"
                     /calculated_mol_wt=43908
     CDS             1..403
                     /gene="LOC124902807"
                     /coded_by="XM_047445906.1:1..1212"
                     /db_xref="GeneID:124902807"
ORIGIN      
        1 myskprpqkd srraeyagff gspppsaqdv sepwsrtgwv sparsiaaqs hhsarcpplr
       61 apglvspflq tvrdpptqpr ekcvegekgt aeghpdpgaq ppplscrpst rslpaclsyp
      121 sislsefrqp rlqgrgslns sivpqwgkph pgwvtaniar twgeschics lapwnrragg
      181 rarahthshp rparpektsl dgggtvfksl sthplrpsit llqlrdpltl prhplgsgtd
      241 rrkhtpserl rarrargapr sapaaaaarg nwekkvllrl pvsrpttsep tdhqptrapt
      301 pcslprsggh gsapvpsalq pagsspspag plppapprpp rvfarrqsgf fqgkcklsee
      361 ekitsrmkhf tsfsfskmis qipceatqnk reslhiwkmh wts
//
LOCUS       XP_047301865             230 aa            linear   PRI 05-AUG-2025
DEFINITION  uncharacterized protein LOC124906971 [Homo sapiens].
ACCESSION   XP_047301865
VERSION     XP_047301865.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_047445909.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060935) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..230
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..230
                     /product="uncharacterized protein LOC124906971"
                     /calculated_mol_wt=24628
     CDS             1..230
                     /gene="LOC124906971"
                     /coded_by="XM_047445909.1:201..893"
                     /db_xref="GeneID:124906971"
ORIGIN      
        1 mnfgsvllka rekphapvht nrhfcpdlcl nqawthlavd llspsrlllc wasrqrmrge
       61 ggkgglersa hfsvlelgki fnvpvtgvsg larkasplpe rvlaadaeqq lrevsaqgss
      121 plttlpqirt gipgrltrea pqrkaqgsdl pgtkhapegq rrrralpdpt lqnpalsqap
      181 tpglqtrlpp laalpaptls hgdawaplal vgetarttlt arllrglees
//
LOCUS       XP_054226664             616 aa            linear   PRI 05-AUG-2025
DEFINITION  SH2B adapter protein 3 isoform X1 [Homo sapiens].
ACCESSION   XP_054226664
VERSION     XP_054226664.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370689.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..616
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..616
                     /product="SH2B adapter protein 3 isoform X1"
                     /calculated_mol_wt=67687
     Region          25..80
                     /region_name="Phe_ZIP"
                     /note="Phenylalanine zipper; pfam08916"
                     /db_xref="CDD:462631"
     Region          194..349
                     /region_name="PH_SH2B_family"
                     /note="SH2B adapter protein 1, 2, and 3 Pleckstrin
                     homology (PH) domain; cd01231"
                     /db_xref="CDD:269938"
     Region          396..492
                     /region_name="SH2_SH2B3"
                     /note="Src homology 2 (SH2) domain found in SH2B adapter
                     proteins (SH2B1, SH2B2, SH2B3); cd10412"
                     /db_xref="CDD:198275"
     Site            order(412,433,454,456)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198275"
     Site            order(455,482)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198275"
     CDS             1..616
                     /gene="SH2B3"
                     /gene_synonym="IDDM20; LNK"
                     /coded_by="XM_054370689.1:383..2233"
                     /db_xref="GeneID:10019"
                     /db_xref="HGNC:HGNC:29605"
                     /db_xref="MIM:605093"
ORIGIN      
        1 mngpalqpss pssapsaspa aaprgwsefc elhavaaare larqywlfar ehpqhaplra
       61 elvslqftdl fqryfcrevr dgrapgrdyr dtgrgppaka easpepgpgp aapglpkars
      121 seelapprpp gpcsfqhfrr slrhifrrrs agelpaahta aapgtpgeaa etparpglak
      181 kflpwslare pppealkeav lrysladeas mdsgarwqrg rlalrrapgp dgpdrvlelf
      241 dppkwpepel srlrfrlkqg lscahvptrc nlagasgigh pyhqssrpkl qaacssiqev
      301 rrctrlempd nlytfvlkvk drtdiifevg deqqlnswma elsectgrgr lesteaemhi
      361 psalepstss sprgstdsln qgaspgglld pacqktdhfl scypwfhgpi srvkaaqlvq
      421 lqgpdahgvf lvrqsetrrg eyvltfnfqg iakhlrlslt ergqcrvqhl hfpsvvdmlh
      481 hfqrspiple cgaacdvrls syvvvvsqpp gscntvlfpf slphwdsesl phwgselglp
      541 hlsssgcprg lspeglpgrs sppeqifhlv pspeelansl qhlehepvnr ardsdyemds
      601 ssrshlraid nqytpl
//
LOCUS       XP_054226665             616 aa            linear   PRI 05-AUG-2025
DEFINITION  SH2B adapter protein 3 isoform X1 [Homo sapiens].
ACCESSION   XP_054226665
VERSION     XP_054226665.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370690.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..616
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..616
                     /product="SH2B adapter protein 3 isoform X1"
                     /calculated_mol_wt=67687
     Region          25..80
                     /region_name="Phe_ZIP"
                     /note="Phenylalanine zipper; pfam08916"
                     /db_xref="CDD:462631"
     Region          194..349
                     /region_name="PH_SH2B_family"
                     /note="SH2B adapter protein 1, 2, and 3 Pleckstrin
                     homology (PH) domain; cd01231"
                     /db_xref="CDD:269938"
     Region          396..492
                     /region_name="SH2_SH2B3"
                     /note="Src homology 2 (SH2) domain found in SH2B adapter
                     proteins (SH2B1, SH2B2, SH2B3); cd10412"
                     /db_xref="CDD:198275"
     Site            order(412,433,454,456)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198275"
     Site            order(455,482)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198275"
     CDS             1..616
                     /gene="SH2B3"
                     /gene_synonym="IDDM20; LNK"
                     /coded_by="XM_054370690.1:101..1951"
                     /db_xref="GeneID:10019"
                     /db_xref="HGNC:HGNC:29605"
                     /db_xref="MIM:605093"
ORIGIN      
        1 mngpalqpss pssapsaspa aaprgwsefc elhavaaare larqywlfar ehpqhaplra
       61 elvslqftdl fqryfcrevr dgrapgrdyr dtgrgppaka easpepgpgp aapglpkars
      121 seelapprpp gpcsfqhfrr slrhifrrrs agelpaahta aapgtpgeaa etparpglak
      181 kflpwslare pppealkeav lrysladeas mdsgarwqrg rlalrrapgp dgpdrvlelf
      241 dppkwpepel srlrfrlkqg lscahvptrc nlagasgigh pyhqssrpkl qaacssiqev
      301 rrctrlempd nlytfvlkvk drtdiifevg deqqlnswma elsectgrgr lesteaemhi
      361 psalepstss sprgstdsln qgaspgglld pacqktdhfl scypwfhgpi srvkaaqlvq
      421 lqgpdahgvf lvrqsetrrg eyvltfnfqg iakhlrlslt ergqcrvqhl hfpsvvdmlh
      481 hfqrspiple cgaacdvrls syvvvvsqpp gscntvlfpf slphwdsesl phwgselglp
      541 hlsssgcprg lspeglpgrs sppeqifhlv pspeelansl qhlehepvnr ardsdyemds
      601 ssrshlraid nqytpl
//
LOCUS       XP_054226667             615 aa            linear   PRI 05-AUG-2025
DEFINITION  SH2B adapter protein 3 isoform X2 [Homo sapiens].
ACCESSION   XP_054226667
VERSION     XP_054226667.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370692.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..615
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..615
                     /product="SH2B adapter protein 3 isoform X2"
                     /calculated_mol_wt=67530
     Region          25..80
                     /region_name="Phe_ZIP"
                     /note="Phenylalanine zipper; pfam08916"
                     /db_xref="CDD:462631"
     Region          194..349
                     /region_name="PH_SH2B_family"
                     /note="SH2B adapter protein 1, 2, and 3 Pleckstrin
                     homology (PH) domain; cd01231"
                     /db_xref="CDD:269938"
     Region          395..491
                     /region_name="SH2_SH2B3"
                     /note="Src homology 2 (SH2) domain found in SH2B adapter
                     proteins (SH2B1, SH2B2, SH2B3); cd10412"
                     /db_xref="CDD:198275"
     Site            order(411,432,453,455)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198275"
     Site            order(454,481)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198275"
     CDS             1..615
                     /gene="SH2B3"
                     /gene_synonym="IDDM20; LNK"
                     /coded_by="XM_054370692.1:101..1948"
                     /db_xref="GeneID:10019"
                     /db_xref="HGNC:HGNC:29605"
                     /db_xref="MIM:605093"
ORIGIN      
        1 mngpalqpss pssapsaspa aaprgwsefc elhavaaare larqywlfar ehpqhaplra
       61 elvslqftdl fqryfcrevr dgrapgrdyr dtgrgppaka easpepgpgp aapglpkars
      121 seelapprpp gpcsfqhfrr slrhifrrrs agelpaahta aapgtpgeaa etparpglak
      181 kflpwslare pppealkeav lrysladeas mdsgarwqrg rlalrrapgp dgpdrvlelf
      241 dppkwpepel srlrfrlkqg lscahvptrc nlagasgigh pyhqssrpkl qaacssiqev
      301 rrctrlempd nlytfvlkvk drtdiifevg deqqlnswma elsectgrgl esteaemhip
      361 salepstsss prgstdslnq gaspgglldp acqktdhfls cypwfhgpis rvkaaqlvql
      421 qgpdahgvfl vrqsetrrge yvltfnfqgi akhlrlslte rgqcrvqhlh fpsvvdmlhh
      481 fqrspiplec gaacdvrlss yvvvvsqppg scntvlfpfs lphwdseslp hwgselglph
      541 lsssgcprgl speglpgrss ppeqifhlvp speelanslq hlehepvnra rdsdyemdss
      601 srshlraidn qytpl
//
LOCUS       XP_054226669             575 aa            linear   PRI 05-AUG-2025
DEFINITION  SH2B adapter protein 3 isoform X4 [Homo sapiens].
ACCESSION   XP_054226669
VERSION     XP_054226669.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370694.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..575
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..575
                     /product="SH2B adapter protein 3 isoform X4"
                     /calculated_mol_wt=63064
     Region          25..80
                     /region_name="Phe_ZIP"
                     /note="Phenylalanine zipper; pfam08916"
                     /db_xref="CDD:462631"
     Region          194..309
                     /region_name="PH_SH2B_family"
                     /note="SH2B adapter protein 1, 2, and 3 Pleckstrin
                     homology (PH) domain; cd01231"
                     /db_xref="CDD:269938"
     Region          355..451
                     /region_name="SH2_SH2B3"
                     /note="Src homology 2 (SH2) domain found in SH2B adapter
                     proteins (SH2B1, SH2B2, SH2B3); cd10412"
                     /db_xref="CDD:198275"
     Site            order(371,392,413,415)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198275"
     Site            order(414,441)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198275"
     CDS             1..575
                     /gene="SH2B3"
                     /gene_synonym="IDDM20; LNK"
                     /coded_by="XM_054370694.1:123..1850"
                     /db_xref="GeneID:10019"
                     /db_xref="HGNC:HGNC:29605"
                     /db_xref="MIM:605093"
ORIGIN      
        1 mngpalqpss pssapsaspa aaprgwsefc elhavaaare larqywlfar ehpqhaplra
       61 elvslqftdl fqryfcrevr dgrapgrdyr dtgrgppaka easpepgpgp aapglpkars
      121 seelapprpp gpcsfqhfrr slrhifrrrs agelpaahta aapgtpgeaa etparpglak
      181 kflpwslare pppealkeav lrysladeas mdsgarwqrg rlalrrapgp dgpdrvlelf
      241 dppkssrpkl qaacssiqev rrctrlempd nlytfvlkvk drtdiifevg deqqlnswma
      301 elsectgrgl esteaemhip salepstsss prgstdslnq gaspgglldp acqktdhfls
      361 cypwfhgpis rvkaaqlvql qgpdahgvfl vrqsetrrge yvltfnfqgi akhlrlslte
      421 rgqcrvqhlh fpsvvdmlhh fqrspiplec gaacdvrlss yvvvvsqppg scntvlfpfs
      481 lphwdseslp hwgselglph lsssgcprgl speglpgrss ppeqifhlvp speelanslq
      541 hlehepvnra rdsdyemdss srshlraidn qytpl
//
LOCUS       XP_054226670             353 aa            linear   PRI 05-AUG-2025
DEFINITION  SH2B adapter protein 3 isoform X5 [Homo sapiens].
ACCESSION   XP_054226670
VERSION     XP_054226670.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370695.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..353
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..353
                     /product="SH2B adapter protein 3 isoform X5"
                     /calculated_mol_wt=38243
     Region          25..80
                     /region_name="Phe_ZIP"
                     /note="Phenylalanine zipper; pfam08916"
                     /db_xref="CDD:462631"
     Region          194..>251
                     /region_name="PH-like"
                     /note="Pleckstrin homology-like domain; cl17171"
                     /db_xref="CDD:473070"
     CDS             1..353
                     /gene="SH2B3"
                     /gene_synonym="IDDM20; LNK"
                     /coded_by="XM_054370695.1:383..1444"
                     /db_xref="GeneID:10019"
                     /db_xref="HGNC:HGNC:29605"
                     /db_xref="MIM:605093"
ORIGIN      
        1 mngpalqpss pssapsaspa aaprgwsefc elhavaaare larqywlfar ehpqhaplra
       61 elvslqftdl fqryfcrevr dgrapgrdyr dtgrgppaka easpepgpgp aapglpkars
      121 seelapprpp gpcsfqhfrr slrhifrrrs agelpaahta aapgtpgeaa etparpglak
      181 kflpwslare pppealkeav lrysladeas mdsgarwqrg rlalrrapgp dgpdrvlelf
      241 dppkwpepel srlrfrlkqg lscahvptrc nlagasgigh pyhqsyhkrk grgkpppeqi
      301 pnrkqlapwl qsapaqeasa gvqgpsykql apasrrsgga hglrclttft plc
//
LOCUS       XP_054226671             309 aa            linear   PRI 05-AUG-2025
DEFINITION  SH2B adapter protein 3 isoform X6 [Homo sapiens].
ACCESSION   XP_054226671
VERSION     XP_054226671.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370696.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..309
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..309
                     /product="SH2B adapter protein 3 isoform X6"
                     /calculated_mol_wt=34148
     Region          <1..42
                     /region_name="PH-like"
                     /note="Pleckstrin homology-like domain; cl17171"
                     /db_xref="CDD:473070"
     Region          89..185
                     /region_name="SH2_SH2B3"
                     /note="Src homology 2 (SH2) domain found in SH2B adapter
                     proteins (SH2B1, SH2B2, SH2B3); cd10412"
                     /db_xref="CDD:198275"
     Site            order(105,126,147,149)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198275"
     Site            order(148,175)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198275"
     CDS             1..309
                     /gene="SH2B3"
                     /gene_synonym="IDDM20; LNK"
                     /coded_by="XM_054370696.1:1259..2188"
                     /db_xref="GeneID:10019"
                     /db_xref="HGNC:HGNC:29605"
                     /db_xref="MIM:605093"
ORIGIN      
        1 mpdnlytfvl kvkdrtdiif evgdeqqlns wmaelsectg rgrlesteae mhipsaleps
       61 tsssprgstd slnqgaspgg lldpacqktd hflscypwfh gpisrvkaaq lvqlqgpdah
      121 gvflvrqset rrgeyvltfn fqgiakhlrl sltergqcrv qhlhfpsvvd mlhhfqrspi
      181 plecgaacdv rlssyvvvvs qppgscntvl fpfslphwds eslphwgsel glphlsssgc
      241 prglspeglp grssppeqif hlvpspeela nslqhlehep vnrardsdye mdsssrshlr
      301 aidnqytpl
//
LOCUS       XP_054226672             308 aa            linear   PRI 05-AUG-2025
DEFINITION  SH2B adapter protein 3 isoform X7 [Homo sapiens].
ACCESSION   XP_054226672
VERSION     XP_054226672.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370697.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..308
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..308
                     /product="SH2B adapter protein 3 isoform X7"
                     /calculated_mol_wt=33992
     Region          <1..42
                     /region_name="PH-like"
                     /note="Pleckstrin homology-like domain; cl17171"
                     /db_xref="CDD:473070"
     Region          88..184
                     /region_name="SH2_SH2B3"
                     /note="Src homology 2 (SH2) domain found in SH2B adapter
                     proteins (SH2B1, SH2B2, SH2B3); cd10412"
                     /db_xref="CDD:198275"
     Site            order(104,125,146,148)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198275"
     Site            order(147,174)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198275"
     CDS             1..308
                     /gene="SH2B3"
                     /gene_synonym="IDDM20; LNK"
                     /coded_by="XM_054370697.1:291..1217"
                     /db_xref="GeneID:10019"
                     /db_xref="HGNC:HGNC:29605"
                     /db_xref="MIM:605093"
ORIGIN      
        1 mpdnlytfvl kvkdrtdiif evgdeqqlns wmaelsectg rglesteaem hipsalepst
       61 sssprgstds lnqgaspggl ldpacqktdh flscypwfhg pisrvkaaql vqlqgpdahg
      121 vflvrqsetr rgeyvltfnf qgiakhlrls ltergqcrvq hlhfpsvvdm lhhfqrspip
      181 lecgaacdvr lssyvvvvsq ppgscntvlf pfslphwdse slphwgselg lphlsssgcp
      241 rglspeglpg rssppeqifh lvpspeelan slqhlehepv nrardsdyem dsssrshlra
      301 idnqytpl
//
LOCUS       XP_054226673             868 aa            linear   PRI 05-AUG-2025
DEFINITION  tastin isoform X6 [Homo sapiens].
ACCESSION   XP_054226673
VERSION     XP_054226673.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370698.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..868
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..868
                     /product="tastin isoform X6"
                     /calculated_mol_wt=93318
     Region          <19..>125
                     /region_name="PTZ00449"
                     /note="104 kDa microneme/rhoptry antigen; Provisional"
                     /db_xref="CDD:185628"
     Region          <501..646
                     /region_name="PspC_subgroup_2"
                     /note="pneumococcal surface protein PspC, LPXTG-anchored
                     form; NF033839"
                     /db_xref="CDD:468202"
     CDS             1..868
                     /gene="TROAP"
                     /gene_synonym="TASTIN"
                     /coded_by="XM_054370698.1:301..2907"
                     /db_xref="GeneID:10024"
                     /db_xref="HGNC:HGNC:12327"
                     /db_xref="MIM:603872"
ORIGIN      
        1 mttrqatkdp llrgvsptps kipvrsqkrt pfptvtscav dqenqdprrw vqkpplniqr
       61 plvdsagprp karhqaetsq rlvgisqprn pleelrpspr gqnvgpgppa qteapgtief
      121 vadpaalati lsgegvksch lgrqpslakr vlvrgsqggt tqrvqgvras aylaprtpth
      181 rldparascf srlegpgprg rtlcpqrlqa lispsgpsfh pstrpsfqel rretagssrt
      241 svsqasglll etpvqpafsl pkgerevvth sdeggvaslg laqrvplren remshtrdsh
      301 dshlmpspap vaqplpghvv pcpspfgraq rvpspgpptl tsysvlrrlt vqpktrftpm
      361 pstprvqqaq wlrgvspqsc sedpalpweq vavrlfdqes cirslegsgk ppvatpsgph
      421 snrtpslqev kiqrigilqq llrqeveglv ggqcvplngg ssldmvelqp llteisrtln
      481 atehnsgtsh lpgllkhsgl pkpclpeecg epqpcppaep gppeafcrse peipepslqe
      541 qlevpepypp aeprplescc rsepeipess rqeqlevpep cppaeprple sycriepeip
      601 essrqeqlev pepcppaepg plqpstqgqs gppgpcprve lgasepctle hrslesslpp
      661 ccsqwapatt slifssqhpl casppicslq slrppagqag kelagkeceh krssphcelh
      721 tcpaptpgnl mlphlppwps lalpqeegrg ctsspvllig lavggggged stwwkyrtpd
      781 lplnfpcpsg lsnlaprtla lrerlksclt aihcfhearl ddecafytsr appsgptrvc
      841 tnpvatllew qdalcfipvg saapqgsp
//
LOCUS       XP_054226674             823 aa            linear   PRI 05-AUG-2025
DEFINITION  tastin isoform X1 [Homo sapiens].
ACCESSION   XP_054226674
VERSION     XP_054226674.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370699.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..823
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..823
                     /product="tastin isoform X1"
                     /calculated_mol_wt=88462
     Region          <19..>125
                     /region_name="PTZ00449"
                     /note="104 kDa microneme/rhoptry antigen; Provisional"
                     /db_xref="CDD:185628"
     Region          <456..601
                     /region_name="PspC_subgroup_2"
                     /note="pneumococcal surface protein PspC, LPXTG-anchored
                     form; NF033839"
                     /db_xref="CDD:468202"
     CDS             1..823
                     /gene="TROAP"
                     /gene_synonym="TASTIN"
                     /coded_by="XM_054370699.1:301..2772"
                     /db_xref="GeneID:10024"
                     /db_xref="HGNC:HGNC:12327"
                     /db_xref="MIM:603872"
ORIGIN      
        1 mttrqatkdp llrgvsptps kipvrsqkrt pfptvtscav dqenqdprrw vqkpplniqr
       61 plvdsagprp karhqaetsq rlvgisqprn pleelrpspr gqnvgpgppa qteapgtief
      121 vadpaalati lsgegvksch lgrqpslakr vlvrgsqggt tqrvqgvras aylaprtpth
      181 rldparascf srlegpgprg rtlcpqrlqa lispsgpsfh pstrpsfqel rretagssrt
      241 svsqasglll etpvqpafsl pkgerevvth sdeggvaslg laqrvplren remshtrdsh
      301 dshlmpspap vaqplpghvv pcpspfgraq rvpspgpptl tsysvlrrlt vqpktrftpm
      361 pstprvqqaq wlrgvspqsc sedpalpwri gilqqllrqe veglvggqcv plnggssldm
      421 velqplltei srtlnatehn sgtshlpgll khsglpkpcl peecgepqpc ppaepgppea
      481 fcrsepeipe pslqeqlevp epyppaeprp lesccrsepe ipessrqeql evpepcppae
      541 prplesycri epeipessrq eqlevpepcp paepgplqps tqgqsgppgp cprvelgase
      601 pctlehrsle sslppccsqw apattslifs sqhplcaspp icslqslrpp agqagkelag
      661 kecehkrssp hcelhtcpap tpgnlmlphl ppwpslalpq eegrgctssp vlliglavgg
      721 gggedstwwk yrtpdlplnf pcpsglsnla prtlalrerl kscltaihcf hearlddeca
      781 fytsrappsg ptrvctnpva tllewqdalc fipvgsaapq gsp
//
LOCUS       XP_054226675             778 aa            linear   PRI 05-AUG-2025
DEFINITION  tastin isoform X7 [Homo sapiens].
ACCESSION   XP_054226675
VERSION     XP_054226675.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370700.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..778
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..778
                     /product="tastin isoform X7"
                     /calculated_mol_wt=83726
     Region          <19..>125
                     /region_name="PTZ00449"
                     /note="104 kDa microneme/rhoptry antigen; Provisional"
                     /db_xref="CDD:185628"
     Region          <501..646
                     /region_name="PspC_subgroup_2"
                     /note="pneumococcal surface protein PspC, LPXTG-anchored
                     form; NF033839"
                     /db_xref="CDD:468202"
     CDS             1..778
                     /gene="TROAP"
                     /gene_synonym="TASTIN"
                     /coded_by="XM_054370700.1:312..2648"
                     /db_xref="GeneID:10024"
                     /db_xref="HGNC:HGNC:12327"
                     /db_xref="MIM:603872"
ORIGIN      
        1 mttrqatkdp llrgvsptps kipvrsqkrt pfptvtscav dqenqdprrw vqkpplniqr
       61 plvdsagprp karhqaetsq rlvgisqprn pleelrpspr gqnvgpgppa qteapgtief
      121 vadpaalati lsgegvksch lgrqpslakr vlvrgsqggt tqrvqgvras aylaprtpth
      181 rldparascf srlegpgprg rtlcpqrlqa lispsgpsfh pstrpsfqel rretagssrt
      241 svsqasglll etpvqpafsl pkgerevvth sdeggvaslg laqrvplren remshtrdsh
      301 dshlmpspap vaqplpghvv pcpspfgraq rvpspgpptl tsysvlrrlt vqpktrftpm
      361 pstprvqqaq wlrgvspqsc sedpalpweq vavrlfdqes cirslegsgk ppvatpsgph
      421 snrtpslqev kiqrigilqq llrqeveglv ggqcvplngg ssldmvelqp llteisrtln
      481 atehnsgtsh lpgllkhsgl pkpclpeecg epqpcppaep gppeafcrse peipepslqe
      541 qlevpepypp aeprplescc rsepeipess rqeqlevpep cppaeprple sycriepeip
      601 essrqeqlev pepcppaepg plqpstqgqs gppgpcprve lgasepctle hrslesslpp
      661 ccsqwapatt slifssqhpl casppicslq slrppagqag lsnlaprtla lrerlksclt
      721 aihcfhearl ddecafytsr appsgptrvc tnpvatllew qdalcfipvg saapqgsp
//
LOCUS       XP_054226676             733 aa            linear   PRI 05-AUG-2025
DEFINITION  tastin isoform X2 [Homo sapiens].
ACCESSION   XP_054226676
VERSION     XP_054226676.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370701.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..733
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..733
                     /product="tastin isoform X2"
                     /calculated_mol_wt=78870
     Region          <19..>125
                     /region_name="PTZ00449"
                     /note="104 kDa microneme/rhoptry antigen; Provisional"
                     /db_xref="CDD:185628"
     Region          <456..601
                     /region_name="PspC_subgroup_2"
                     /note="pneumococcal surface protein PspC, LPXTG-anchored
                     form; NF033839"
                     /db_xref="CDD:468202"
     CDS             1..733
                     /gene="TROAP"
                     /gene_synonym="TASTIN"
                     /coded_by="XM_054370701.1:301..2502"
                     /db_xref="GeneID:10024"
                     /db_xref="HGNC:HGNC:12327"
                     /db_xref="MIM:603872"
ORIGIN      
        1 mttrqatkdp llrgvsptps kipvrsqkrt pfptvtscav dqenqdprrw vqkpplniqr
       61 plvdsagprp karhqaetsq rlvgisqprn pleelrpspr gqnvgpgppa qteapgtief
      121 vadpaalati lsgegvksch lgrqpslakr vlvrgsqggt tqrvqgvras aylaprtpth
      181 rldparascf srlegpgprg rtlcpqrlqa lispsgpsfh pstrpsfqel rretagssrt
      241 svsqasglll etpvqpafsl pkgerevvth sdeggvaslg laqrvplren remshtrdsh
      301 dshlmpspap vaqplpghvv pcpspfgraq rvpspgpptl tsysvlrrlt vqpktrftpm
      361 pstprvqqaq wlrgvspqsc sedpalpwri gilqqllrqe veglvggqcv plnggssldm
      421 velqplltei srtlnatehn sgtshlpgll khsglpkpcl peecgepqpc ppaepgppea
      481 fcrsepeipe pslqeqlevp epyppaeprp lesccrsepe ipessrqeql evpepcppae
      541 prplesycri epeipessrq eqlevpepcp paepgplqps tqgqsgppgp cprvelgase
      601 pctlehrsle sslppccsqw apattslifs sqhplcaspp icslqslrpp agqaglsnla
      661 prtlalrerl kscltaihcf hearlddeca fytsrappsg ptrvctnpva tllewqdalc
      721 fipvgsaapq gsp
//
LOCUS       XP_054226677             618 aa            linear   PRI 05-AUG-2025
DEFINITION  tastin isoform X3 [Homo sapiens].
ACCESSION   XP_054226677
VERSION     XP_054226677.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370702.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..618
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..618
                     /product="tastin isoform X3"
                     /calculated_mol_wt=66967
     Region          <19..>125
                     /region_name="PTZ00449"
                     /note="104 kDa microneme/rhoptry antigen; Provisional"
                     /db_xref="CDD:185628"
     Region          <501..609
                     /region_name="PspC_subgroup_2"
                     /note="pneumococcal surface protein PspC, LPXTG-anchored
                     form; NF033839"
                     /db_xref="CDD:468202"
     CDS             1..618
                     /gene="TROAP"
                     /gene_synonym="TASTIN"
                     /coded_by="XM_054370702.1:301..2157"
                     /db_xref="GeneID:10024"
                     /db_xref="HGNC:HGNC:12327"
                     /db_xref="MIM:603872"
ORIGIN      
        1 mttrqatkdp llrgvsptps kipvrsqkrt pfptvtscav dqenqdprrw vqkpplniqr
       61 plvdsagprp karhqaetsq rlvgisqprn pleelrpspr gqnvgpgppa qteapgtief
      121 vadpaalati lsgegvksch lgrqpslakr vlvrgsqggt tqrvqgvras aylaprtpth
      181 rldparascf srlegpgprg rtlcpqrlqa lispsgpsfh pstrpsfqel rretagssrt
      241 svsqasglll etpvqpafsl pkgerevvth sdeggvaslg laqrvplren remshtrdsh
      301 dshlmpspap vaqplpghvv pcpspfgraq rvpspgpptl tsysvlrrlt vqpktrftpm
      361 pstprvqqaq wlrgvspqsc sedpalpweq vavrlfdqes cirslegsgk ppvatpsgph
      421 snrtpslqev kiqrigilqq llrqeveglv ggqcvplngg ssldmvelqp llteisrtln
      481 atehnsgtsh lpgllkhsgl pkpclpeecg epqpcppaep gppeafcrse peipepslqe
      541 qlevpepypp aeprplescc rsepeipess rqeqlevpep cppaeprple sycriepeip
      601 essrqeqlea saiwplep
//
LOCUS       XP_054226678             576 aa            linear   PRI 05-AUG-2025
DEFINITION  tastin isoform X4 [Homo sapiens].
ACCESSION   XP_054226678
VERSION     XP_054226678.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370703.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..576
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..576
                     /product="tastin isoform X4"
                     /calculated_mol_wt=61879
     Region          <209..354
                     /region_name="PspC_subgroup_2"
                     /note="pneumococcal surface protein PspC, LPXTG-anchored
                     form; NF033839"
                     /db_xref="CDD:468202"
     CDS             1..576
                     /gene="TROAP"
                     /gene_synonym="TASTIN"
                     /coded_by="XM_054370703.1:620..2350"
                     /db_xref="GeneID:10024"
                     /db_xref="HGNC:HGNC:12327"
                     /db_xref="MIM:603872"
ORIGIN      
        1 mshtrdshds hlmpspapva qplpghvvpc pspfgraqrv pspgpptlts ysvlrrltvq
       61 pktrftpmps tprvqqaqwl rgvspqscse dpalpweqva vrlfdqesci rslegsgkpp
      121 vatpsgphsn rtpslqevki qrigilqqll rqeveglvgg qcvplnggss ldmvelqpll
      181 teisrtlnat ehnsgtshlp gllkhsglpk pclpeecgep qpcppaepgp peafcrsepe
      241 ipepslqeql evpepyppae prplesccrs epeipessrq eqlevpepcp paeprplesy
      301 criepeipes srqeqlevpe pcppaepgpl qpstqgqsgp pgpcprvelg asepctlehr
      361 slesslppcc sqwapattsl ifssqhplca sppicslqsl rppagqagke lagkecehkr
      421 ssphcelhtc paptpgnlml phlppwpsla lpqeegrgct sspvlligla vgggggedst
      481 wwkyrtpdlp lnfpcpsgls nlaprtlalr erlkscltai hcfhearldd ecafytsrap
      541 psgptrvctn pvatllewqd alcfipvgsa apqgsp
//
LOCUS       XP_054226679             576 aa            linear   PRI 05-AUG-2025
DEFINITION  tastin isoform X4 [Homo sapiens].
ACCESSION   XP_054226679
VERSION     XP_054226679.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370704.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..576
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..576
                     /product="tastin isoform X4"
                     /calculated_mol_wt=61879
     Region          <209..354
                     /region_name="PspC_subgroup_2"
                     /note="pneumococcal surface protein PspC, LPXTG-anchored
                     form; NF033839"
                     /db_xref="CDD:468202"
     CDS             1..576
                     /gene="TROAP"
                     /gene_synonym="TASTIN"
                     /coded_by="XM_054370704.1:649..2379"
                     /db_xref="GeneID:10024"
                     /db_xref="HGNC:HGNC:12327"
                     /db_xref="MIM:603872"
ORIGIN      
        1 mshtrdshds hlmpspapva qplpghvvpc pspfgraqrv pspgpptlts ysvlrrltvq
       61 pktrftpmps tprvqqaqwl rgvspqscse dpalpweqva vrlfdqesci rslegsgkpp
      121 vatpsgphsn rtpslqevki qrigilqqll rqeveglvgg qcvplnggss ldmvelqpll
      181 teisrtlnat ehnsgtshlp gllkhsglpk pclpeecgep qpcppaepgp peafcrsepe
      241 ipepslqeql evpepyppae prplesccrs epeipessrq eqlevpepcp paeprplesy
      301 criepeipes srqeqlevpe pcppaepgpl qpstqgqsgp pgpcprvelg asepctlehr
      361 slesslppcc sqwapattsl ifssqhplca sppicslqsl rppagqagke lagkecehkr
      421 ssphcelhtc paptpgnlml phlppwpsla lpqeegrgct sspvlligla vgggggedst
      481 wwkyrtpdlp lnfpcpsgls nlaprtlalr erlkscltai hcfhearldd ecafytsrap
      541 psgptrvctn pvatllewqd alcfipvgsa apqgsp
//
LOCUS       XP_054226680             398 aa            linear   PRI 05-AUG-2025
DEFINITION  tastin isoform X5 [Homo sapiens].
ACCESSION   XP_054226680
VERSION     XP_054226680.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370705.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..398
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..398
                     /product="tastin isoform X5"
                     /calculated_mol_wt=42899
     Region          <16..397
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          <19..>125
                     /region_name="PTZ00449"
                     /note="104 kDa microneme/rhoptry antigen; Provisional"
                     /db_xref="CDD:185628"
     CDS             1..398
                     /gene="TROAP"
                     /gene_synonym="TASTIN"
                     /coded_by="XM_054370705.1:301..1497"
                     /db_xref="GeneID:10024"
                     /db_xref="HGNC:HGNC:12327"
                     /db_xref="MIM:603872"
ORIGIN      
        1 mttrqatkdp llrgvsptps kipvrsqkrt pfptvtscav dqenqdprrw vqkpplniqr
       61 plvdsagprp karhqaetsq rlvgisqprn pleelrpspr gqnvgpgppa qteapgtief
      121 vadpaalati lsgegvksch lgrqpslakr vlvrgsqggt tqrvqgvras aylaprtpth
      181 rldparascf srlegpgprg rtlcpqrlqa lispsgpsfh pstrpsfqel rretagssrt
      241 svsqasglll etpvqpafsl pkgerevvth sdeggvaslg laqrvplren remshtrdsh
      301 dshlmpspap vaqplpghvv pcpspfgraq rvpspgpptl tsysvlrrlt vqpktrftpm
      361 pstprvqqaq wlrgvspqsc sedpalpwpg llvclvpw
//
LOCUS       XP_054226681             144 aa            linear   PRI 05-AUG-2025
DEFINITION  tastin isoform X8 [Homo sapiens].
ACCESSION   XP_054226681
VERSION     XP_054226681.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370706.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..144
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..144
                     /product="tastin isoform X8"
                     /calculated_mol_wt=15762
     Region          <19..>132
                     /region_name="PTZ00449"
                     /note="104 kDa microneme/rhoptry antigen; Provisional"
                     /db_xref="CDD:185628"
     CDS             1..144
                     /gene="TROAP"
                     /gene_synonym="TASTIN"
                     /coded_by="XM_054370706.1:301..735"
                     /db_xref="GeneID:10024"
                     /db_xref="HGNC:HGNC:12327"
                     /db_xref="MIM:603872"
ORIGIN      
        1 mttrqatkdp llrgvsptps kipvrsqkrt pfptvtscav dqenqdprrw vqkpplniqr
       61 plvdsagprp karhqaetsq rlvgisqprn pleelrpspr gqnvgpgppa qtvlvpapgk
      121 lfalrrspfp pakchlarch glyl
//
LOCUS       XP_054226682             126 aa            linear   PRI 05-AUG-2025
DEFINITION  tastin isoform X9 [Homo sapiens].
ACCESSION   XP_054226682
VERSION     XP_054226682.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370707.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..126
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..126
                     /product="tastin isoform X9"
                     /calculated_mol_wt=13591
     Region          <19..>100
                     /region_name="PTZ00449"
                     /note="104 kDa microneme/rhoptry antigen; Provisional"
                     /db_xref="CDD:185628"
     CDS             1..126
                     /gene="TROAP"
                     /gene_synonym="TASTIN"
                     /coded_by="XM_054370707.1:301..681"
                     /db_xref="GeneID:10024"
                     /db_xref="HGNC:HGNC:12327"
                     /db_xref="MIM:603872"
ORIGIN      
        1 mttrqatkdp llrgvsptps kipvrsqkrt pfptvtscav dqenqdprrw vqkpplniqr
       61 plvdsagprp karhqaetsq rlvgisqprn pleelrpspr gqnvgpgppa qtgamactcn
      121 hsysgg
//
LOCUS       XP_054226683             313 aa            linear   PRI 05-AUG-2025
DEFINITION  MANSC domain-containing protein 4 isoform X1 [Homo sapiens].
ACCESSION   XP_054226683
VERSION     XP_054226683.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370708.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 22% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..313
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..313
                     /product="MANSC domain-containing protein 4 isoform X1"
                     /calculated_mol_wt=34914
     Region          3..90
                     /region_name="MANEC"
                     /note="The MANEC domain, formerly called MANSC;
                     smart00765"
                     /db_xref="CDD:129004"
     CDS             1..313
                     /gene="MANSC4"
                     /coded_by="XM_054370708.1:2426..3367"
                     /db_xref="GeneID:100287284"
                     /db_xref="HGNC:HGNC:40023"
ORIGIN      
        1 mwqrdcwirr fpgllinlee sqklgaqflk yysestgqkc srscclrkdv scnlavfyhs
       61 pihdninclh vhcptlesci lepgtsaily nitdgidpdl lvfeqsptyl ntrsssnrwd
      121 rlrilkamnl dkqtttingm lpsteapsst thqdlvvntn stsyskeltt dfwarftsln
      181 esittkinkv spstdfisnp dnktispffe pidtklshmp vppglnsskq llnktkgyns
      241 rnhtsanede vsvtsktwlv svalctsvif lgccivilas gccgkqqgqy kpgqrksgsl
      301 qiknrnhmke nss
//
LOCUS       XP_054226684             213 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich colipase-like protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_054226684
VERSION     XP_054226684.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370709.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 4% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..213
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..213
                     /product="leucine-rich colipase-like protein 1 isoform X1"
                     /calculated_mol_wt=23425
     Region          66..153
                     /region_name="Colipase-like"
                     /note="pfam15083"
                     /db_xref="CDD:464492"
     CDS             1..213
                     /gene="LRCOL1"
                     /coded_by="XM_054370709.1:274..915"
                     /db_xref="GeneID:100507055"
                     /db_xref="HGNC:HGNC:44160"
ORIGIN      
        1 magpgwtlll llllllllgs magygpqkkl nlshkgigep crrheecqsn cctinslaph
       61 tlctpktifl qclpwrkpng yrcshdsecq ssccvrnnsp qelctpqsvf lqcvpwrkpn
      121 gdfcsshqec hsqcciqlre yspfrciprt gilaqclplv spgrglslqa lpwppqgsrt
      181 etqqldrdrg cerwalstqa pllgeagasp pis
//
LOCUS       XP_054226685             161 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich colipase-like protein 1 isoform X2 [Homo sapiens].
ACCESSION   XP_054226685
VERSION     XP_054226685.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370710.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..161
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..161
                     /product="leucine-rich colipase-like protein 1 isoform X2"
                     /calculated_mol_wt=17459
     Region          25..101
                     /region_name="Colipase-like"
                     /note="pfam15083"
                     /db_xref="CDD:464492"
     CDS             1..161
                     /gene="LRCOL1"
                     /coded_by="XM_054370710.1:339..824"
                     /db_xref="GeneID:100507055"
                     /db_xref="HGNC:HGNC:44160"
ORIGIN      
        1 mvtqgsqgeg rpflsaesag paqeqpngyr cshdsecqss ccvrnnspqe lctpqsvflq
       61 cvpwrkpngd fcsshqechs qcciqlreys pfrciprtgi laqclplvsp grglslqalp
      121 wppqgsrtet qqldrdrgce rwalstqapl lgeagasppi s
//
LOCUS       XP_054226686             161 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich colipase-like protein 1 isoform X2 [Homo sapiens].
ACCESSION   XP_054226686
VERSION     XP_054226686.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370711.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..161
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..161
                     /product="leucine-rich colipase-like protein 1 isoform X2"
                     /calculated_mol_wt=17459
     Region          25..101
                     /region_name="Colipase-like"
                     /note="pfam15083"
                     /db_xref="CDD:464492"
     CDS             1..161
                     /gene="LRCOL1"
                     /coded_by="XM_054370711.1:270..755"
                     /db_xref="GeneID:100507055"
                     /db_xref="HGNC:HGNC:44160"
ORIGIN      
        1 mvtqgsqgeg rpflsaesag paqeqpngyr cshdsecqss ccvrnnspqe lctpqsvflq
       61 cvpwrkpngd fcsshqechs qcciqlreys pfrciprtgi laqclplvsp grglslqalp
      121 wppqgsrtet qqldrdrgce rwalstqapl lgeagasppi s
//
LOCUS       XP_054226687             161 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich colipase-like protein 1 isoform X2 [Homo sapiens].
ACCESSION   XP_054226687
VERSION     XP_054226687.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370712.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..161
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..161
                     /product="leucine-rich colipase-like protein 1 isoform X2"
                     /calculated_mol_wt=17459
     Region          25..101
                     /region_name="Colipase-like"
                     /note="pfam15083"
                     /db_xref="CDD:464492"
     CDS             1..161
                     /gene="LRCOL1"
                     /coded_by="XM_054370712.1:162..647"
                     /db_xref="GeneID:100507055"
                     /db_xref="HGNC:HGNC:44160"
ORIGIN      
        1 mvtqgsqgeg rpflsaesag paqeqpngyr cshdsecqss ccvrnnspqe lctpqsvflq
       61 cvpwrkpngd fcsshqechs qcciqlreys pfrciprtgi laqclplvsp grglslqalp
      121 wppqgsrtet qqldrdrgce rwalstqapl lgeagasppi s
//
LOCUS       XP_054226688             161 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich colipase-like protein 1 isoform X2 [Homo sapiens].
ACCESSION   XP_054226688
VERSION     XP_054226688.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370713.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..161
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..161
                     /product="leucine-rich colipase-like protein 1 isoform X2"
                     /calculated_mol_wt=17459
     Region          25..101
                     /region_name="Colipase-like"
                     /note="pfam15083"
                     /db_xref="CDD:464492"
     CDS             1..161
                     /gene="LRCOL1"
                     /coded_by="XM_054370713.1:157..642"
                     /db_xref="GeneID:100507055"
                     /db_xref="HGNC:HGNC:44160"
ORIGIN      
        1 mvtqgsqgeg rpflsaesag paqeqpngyr cshdsecqss ccvrnnspqe lctpqsvflq
       61 cvpwrkpngd fcsshqechs qcciqlreys pfrciprtgi laqclplvsp grglslqalp
      121 wppqgsrtet qqldrdrgce rwalstqapl lgeagasppi s
//
LOCUS       XP_054226689             107 aa            linear   PRI 05-AUG-2025
DEFINITION  leucine-rich colipase-like protein 1 isoform X3 [Homo sapiens].
ACCESSION   XP_054226689
VERSION     XP_054226689.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370714.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..107
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..107
                     /product="leucine-rich colipase-like protein 1 isoform X3"
                     /calculated_mol_wt=11736
     Region          25..101
                     /region_name="Colipase-like"
                     /note="pfam15083"
                     /db_xref="CDD:464492"
     CDS             1..107
                     /gene="LRCOL1"
                     /coded_by="XM_054370714.1:339..662"
                     /db_xref="GeneID:100507055"
                     /db_xref="HGNC:HGNC:44160"
ORIGIN      
        1 mvtqgsqgeg rpflsaesag paqeqpngyr cshdsecqss ccvrnnspqe lctpqsvflq
       61 cvpwrkpngd fcsshqechs qcciqlreys pfrciprtgi laqclpl
//
LOCUS       XP_054226691             517 aa            linear   PRI 05-AUG-2025
DEFINITION  dynamin-1-like protein isoform X2 [Homo sapiens].
ACCESSION   XP_054226691
VERSION     XP_054226691.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370716.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..517
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..517
                     /product="dynamin-1-like protein isoform X2"
                     /calculated_mol_wt=57558
     Region          6..291
                     /region_name="Dynamin_M"
                     /note="Dynamin central region; pfam01031"
                     /db_xref="CDD:460033"
     Region          421..511
                     /region_name="GED"
                     /note="Dynamin GTPase effector domain; pfam02212"
                     /db_xref="CDD:460495"
     CDS             1..517
                     /gene="DNM1L"
                     /gene_synonym="DLP1; DRP1; DVLP; DYMPLE; EMPF; EMPF1;
                     HDYNIV; OPA5"
                     /coded_by="XM_054370716.1:97..1650"
                     /db_xref="GeneID:10059"
                     /db_xref="HGNC:HGNC:2973"
                     /db_xref="MIM:603850"
ORIGIN      
        1 mdagtdamdv lmgrvipvkl giigvvnrsq ldinnkksvt dsirdeyafl qkkypslanr
       61 ngtkylartl nrllmhhird clpelktrin vlaaqyqsll nsygepvddk satllqlitk
      121 fateycntie gtakyietse lcggaricyi fhetfgrtle svdplgglnt idiltairna
      181 tgprpalfvp evsfellvkr qikrleepsl rcvelvheem qriiqhcsny stqellrfpk
      241 lhdaivevvt cllrkrlpvt nemvhnlvai elayintkhp dfadacglmn nnieeqrrnr
      301 larelpsavs rdksskvpsa lapasqepsp aasaeadgkl iqdsrretkn vasggggvgd
      361 gvqepttgnw rgmlktskae ellaeekskp ipimpaspqk ghavnlldvp vpvarklsar
      421 eqrdcevier liksyflivr kniqdsvpka vmhflvnhvk dtlqselvgq lykssllddl
      481 ltesedmaqr rkeaadmlka lqgasqiiae irethlw
//
LOCUS       XP_054226692            1549 aa            linear   PRI 05-AUG-2025
DEFINITION  ATP-binding cassette sub-family C member 9 isoform X1 [Homo
            sapiens].
ACCESSION   XP_054226692
VERSION     XP_054226692.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370717.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1549
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1549
                     /product="ATP-binding cassette sub-family C member 9
                     isoform X1"
                     /calculated_mol_wt=174294
     Region          222..1546
                     /region_name="MRP_assoc_pro"
                     /note="multi drug resistance-associated protein (MRP);
                     TIGR00957"
                     /db_xref="CDD:188098"
     CDS             1..1549
                     /gene="ABCC9"
                     /gene_synonym="ABC37; ATFB12; CANTU; CMD1O; IDMYS; SUR2"
                     /coded_by="XM_054370717.1:1149..5798"
                     /db_xref="GeneID:10060"
                     /db_xref="HGNC:HGNC:60"
                     /db_xref="MIM:601439"
ORIGIN      
        1 mslsfcgnni ssynindgvl qnscfvdaln lvphvfllfi tfpilfigwg sqsskvqihh
       61 ntwlhfpghn lrwiltfall fvhvceiaeg ivsdsrresr hlhlfmpavm gfvatttsiv
      121 yyhnietsnf pklllalfly wvmafitkti klvkycqsgl disnlrfcit gmmvilngll
      181 maveinvirv rryvffmnpq kvkppedlqd lgvrflqpfv nllskatyww mntliisahk
      241 kpidlkaigk lpiamravtn yvclkdayee qkkkvadhpn rtpsiwlamy rafgrpills
      301 stfryladll gfagplcisg ivqrvnetqn gtnnttgise tlsskeflen ayvlavllfl
      361 alilqrtflq asyyvtietg inlrgallam iynkilrlst snlsmgemtl gqinnlvaie
      421 tnqlmwflfl cpnlwampvq iimgvillyn llgssalvga avivllapiq yfiatklaea
      481 qkstldyste rlkktneilk gikllklyaw ehifcksvee trmkelsslk tfalytslsi
      541 fmnaaipiaa vlatfvthay asgnnlkpae afaslslfhi lvtplfllst vvrfavkaii
      601 svqklnefll sdeigddswr tgesslpfes ckkhtgvqpk tinrkqpgry hldsyeqstr
      661 rlrpaetedi aikvtngyfs wgsglatlsn idiriptgql tmivgqvgcg ksslllailg
      721 emqtlegkvh wsnvneseps featrsrnry svayaaqkpw llnatveeni tfgspfnkqr
      781 ykavtdacsl qpdidllpfg dqteigergi nlsggqrqri cvaralyqnt nivflddpfs
      841 aldihlsdhl mqegilkflq ddkrtlvlvt hklqylthad wiiamkdgsv lregtlkdiq
      901 tkdvelyehw ktlmnrqdqe lekdmeadqt tlerktlrra mysreakaqm ededeeeeee
      961 ededdnmstv mrlrtkmpwk tcwryltsgg ffllilmifs kllkhsviva idywlatwts
     1021 eysinntgka dqtyyvagfs ilcgagiflc lvtsltvewm gltaaknlhh nllnkiilgp
     1081 irffdttplg lilnrfsadt niidqhippt lesltrstll clsaigmisy atpvflvall
     1141 plgvafyfiq kyfrvaskdl qelddstqlp llchfsetae glttirafrh etrfkqrmle
     1201 ltdtnniayl flsaanrwle vrtdylgaci vltasiasis gssnsglvgl gllyaltitn
     1261 ylnwvvrnla dlevqmgavk kvnsfltmes enyegtmdps qvpehwpqeg eikihdlcvr
     1321 yennlkpvlk hvkayikpgq kvgicgrtgs gksslslaff rmvdifdgki vidgidiskl
     1381 plhtlrsrls iilqdpilfs gsirfnldpe ckctddrlwe aleiaqlknm vkslpgglda
     1441 vvteggenfs vgqrqlfcla rafvrkssil imdeatasid matenilqkv vmtafadrtv
     1501 vtiahrvhti ltadlvivmk rgnileydtp esllaqengv fasfvradm
//
LOCUS       XP_054226693            1549 aa            linear   PRI 05-AUG-2025
DEFINITION  ATP-binding cassette sub-family C member 9 isoform X1 [Homo
            sapiens].
ACCESSION   XP_054226693
VERSION     XP_054226693.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370718.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1549
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1549
                     /product="ATP-binding cassette sub-family C member 9
                     isoform X1"
                     /calculated_mol_wt=174294
     Region          222..1546
                     /region_name="MRP_assoc_pro"
                     /note="multi drug resistance-associated protein (MRP);
                     TIGR00957"
                     /db_xref="CDD:188098"
     CDS             1..1549
                     /gene="ABCC9"
                     /gene_synonym="ABC37; ATFB12; CANTU; CMD1O; IDMYS; SUR2"
                     /coded_by="XM_054370718.1:248..4897"
                     /db_xref="GeneID:10060"
                     /db_xref="HGNC:HGNC:60"
                     /db_xref="MIM:601439"
ORIGIN      
        1 mslsfcgnni ssynindgvl qnscfvdaln lvphvfllfi tfpilfigwg sqsskvqihh
       61 ntwlhfpghn lrwiltfall fvhvceiaeg ivsdsrresr hlhlfmpavm gfvatttsiv
      121 yyhnietsnf pklllalfly wvmafitkti klvkycqsgl disnlrfcit gmmvilngll
      181 maveinvirv rryvffmnpq kvkppedlqd lgvrflqpfv nllskatyww mntliisahk
      241 kpidlkaigk lpiamravtn yvclkdayee qkkkvadhpn rtpsiwlamy rafgrpills
      301 stfryladll gfagplcisg ivqrvnetqn gtnnttgise tlsskeflen ayvlavllfl
      361 alilqrtflq asyyvtietg inlrgallam iynkilrlst snlsmgemtl gqinnlvaie
      421 tnqlmwflfl cpnlwampvq iimgvillyn llgssalvga avivllapiq yfiatklaea
      481 qkstldyste rlkktneilk gikllklyaw ehifcksvee trmkelsslk tfalytslsi
      541 fmnaaipiaa vlatfvthay asgnnlkpae afaslslfhi lvtplfllst vvrfavkaii
      601 svqklnefll sdeigddswr tgesslpfes ckkhtgvqpk tinrkqpgry hldsyeqstr
      661 rlrpaetedi aikvtngyfs wgsglatlsn idiriptgql tmivgqvgcg ksslllailg
      721 emqtlegkvh wsnvneseps featrsrnry svayaaqkpw llnatveeni tfgspfnkqr
      781 ykavtdacsl qpdidllpfg dqteigergi nlsggqrqri cvaralyqnt nivflddpfs
      841 aldihlsdhl mqegilkflq ddkrtlvlvt hklqylthad wiiamkdgsv lregtlkdiq
      901 tkdvelyehw ktlmnrqdqe lekdmeadqt tlerktlrra mysreakaqm ededeeeeee
      961 ededdnmstv mrlrtkmpwk tcwryltsgg ffllilmifs kllkhsviva idywlatwts
     1021 eysinntgka dqtyyvagfs ilcgagiflc lvtsltvewm gltaaknlhh nllnkiilgp
     1081 irffdttplg lilnrfsadt niidqhippt lesltrstll clsaigmisy atpvflvall
     1141 plgvafyfiq kyfrvaskdl qelddstqlp llchfsetae glttirafrh etrfkqrmle
     1201 ltdtnniayl flsaanrwle vrtdylgaci vltasiasis gssnsglvgl gllyaltitn
     1261 ylnwvvrnla dlevqmgavk kvnsfltmes enyegtmdps qvpehwpqeg eikihdlcvr
     1321 yennlkpvlk hvkayikpgq kvgicgrtgs gksslslaff rmvdifdgki vidgidiskl
     1381 plhtlrsrls iilqdpilfs gsirfnldpe ckctddrlwe aleiaqlknm vkslpgglda
     1441 vvteggenfs vgqrqlfcla rafvrkssil imdeatasid matenilqkv vmtafadrtv
     1501 vtiahrvhti ltadlvivmk rgnileydtp esllaqengv fasfvradm
//
LOCUS       XP_054226695            1502 aa            linear   PRI 05-AUG-2025
DEFINITION  ATP-binding cassette sub-family C member 9 isoform X3 [Homo
            sapiens].
ACCESSION   XP_054226695
VERSION     XP_054226695.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370720.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1502
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1502
                     /product="ATP-binding cassette sub-family C member 9
                     isoform X3"
                     /calculated_mol_wt=168922
     Region          222..1499
                     /region_name="MRP_assoc_pro"
                     /note="multi drug resistance-associated protein (MRP);
                     TIGR00957"
                     /db_xref="CDD:188098"
     CDS             1..1502
                     /gene="ABCC9"
                     /gene_synonym="ABC37; ATFB12; CANTU; CMD1O; IDMYS; SUR2"
                     /coded_by="XM_054370720.1:364..4872"
                     /db_xref="GeneID:10060"
                     /db_xref="HGNC:HGNC:60"
                     /db_xref="MIM:601439"
ORIGIN      
        1 mslsfcgnni ssynindgvl qnscfvdaln lvphvfllfi tfpilfigwg sqsskvqihh
       61 ntwlhfpghn lrwiltfall fvhvceiaeg ivsdsrresr hlhlfmpavm gfvatttsiv
      121 yyhnietsnf pklllalfly wvmafitkti klvkycqsgl disnlrfcit gmmvilngll
      181 maveinvirv rryvffmnpq kvkppedlqd lgvrflqpfv nllskatyww mntliisahk
      241 kpidlkaigk lpiamravtn yvclkdayee qkkkvadhpn rtpsiwlamy rafgrpills
      301 stfryladll gfagplcisg ivqrvnetqn gtnnttgise tlsskeflen ayvlavllfl
      361 alilqrtflq asyyvtietg inlrgallam iynkilrlst snlsmgemtl gqinnlvaie
      421 tnqlmwflfl cpnlwampvq iimgvillyn llgssalvga avivllapiq yfiatklaea
      481 qkstldyste rlkktneilk gikllklyaw ehifcksvee trmkelsslk tfalytslsi
      541 fmnaaipiaa vlatfvthay asgnnlkpae afaslslfhi lvtplfllst vvrfavkaii
      601 svqklnefll sdeigddswr tgesslpfes ckkhtgvqpk tinrkqpgry hldsyeqstr
      661 rlrpaetedi aikvtngyfs wgsglatlsn idiriptgql tmivgqvgcg ksslllailg
      721 emqtlegkvh wskykavtda cslqpdidll pfgdqteige rginlsggqr qricvaraly
      781 qntnivfldd pfsaldihls dhlmqegilk flqddkrtlv lvthklqylt hadwiiamkd
      841 gsvlregtlk diqtkdvely ehwktlmnrq dqelekdmea dqttlerktl rramysreak
      901 aqmededeee eeeededdnm stvmrlrtkm pwktcwrylt sggffllilm ifskllkhsv
      961 ivaidywlat wtseysinnt gkadqtyyva gfsilcgagi flclvtsltv ewmgltaakn
     1021 lhhnllnkii lgpirffdtt plglilnrfs adtniidqhi pptlesltrs tllclsaigm
     1081 isyatpvflv allplgvafy fiqkyfrvas kdlqelddst qlpllchfse taeglttira
     1141 frhetrfkqr mleltdtnni aylflsaanr wlevrtdylg acivltasia sisgssnsgl
     1201 vglgllyalt itnylnwvvr nladlevqmg avkkvnsflt mesenyegtm dpsqvpehwp
     1261 qegeikihdl cvryennlkp vlkhvkayik pgqkvgicgr tgsgksslsl affrmvdifd
     1321 gkividgidi sklplhtlrs rlsiilqdpi lfsgsirfnl dpeckctddr lwealeiaql
     1381 knmvkslpgg ldavvtegge nfsvgqrqlf clarafvrks silimdeata sidmatenil
     1441 qkvvmtafad rtvvtiahrv htiltadlvi vmkrgniley dtpesllaqe ngvfasfvra
     1501 dm
//
LOCUS       XP_054226696             277 aa            linear   PRI 05-AUG-2025
DEFINITION  carboxy-terminal domain RNA polymerase II polypeptide A small
            phosphatase 2 isoform X1 [Homo sapiens].
ACCESSION   XP_054226696
VERSION     XP_054226696.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370721.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..277
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..277
                     /product="carboxy-terminal domain RNA polymerase II
                     polypeptide A small phosphatase 2 isoform X1"
                     /calculated_mol_wt=31161
     Region          107..266
                     /region_name="HIF-SF_euk"
                     /note="Dullard-like phosphatase domain; TIGR02251"
                     /db_xref="CDD:274055"
     Site            order(113..117,121..122,168..171,175,207,223..224,
                     226..228)
                     /site_type="active"
                     /db_xref="CDD:319823"
     CDS             1..277
                     /gene="CTDSP2"
                     /gene_synonym="OS4; PSR2; SCP2"
                     /coded_by="XM_054370721.1:295..1128"
                     /db_xref="GeneID:10106"
                     /db_xref="HGNC:HGNC:17077"
                     /db_xref="MIM:608711"
ORIGIN      
        1 mehgsiitqa rredalvltk qglvsksspk kprgrnifka lfccfraqhv gqsssstela
       61 aykeeantia ksdllqclqy qfyqvrdsgl ipgtcllpev teedqgricv vidldetlvh
      121 ssfkpinnad fivpieiegt thqvyvlkrp yvdeflrrmg elfecvlfta slakyadpvt
      181 dlldrcgvfr arlfrescvf hqgcyvkdls rlgrdlrktl ildnspasyi fhpenavpvq
      241 swfddmadte llnlipifee lsgaedvyts lgqlrap
//
LOCUS       XP_054226697             238 aa            linear   PRI 05-AUG-2025
DEFINITION  YY1-associated factor 2 isoform X1 [Homo sapiens].
ACCESSION   XP_054226697
VERSION     XP_054226697.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370722.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..238
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..238
                     /product="YY1-associated factor 2 isoform X1"
                     /calculated_mol_wt=26306
     Region          20..43
                     /region_name="zf-RanBP"
                     /note="Zn-finger in Ran binding protein and others;
                     pfam00641"
                     /db_xref="CDD:395516"
     Region          23..42
                     /region_name="RanBP2-type Zn finger"
                     /note="RanBP2-type Zn finger [structural motif]"
                     /db_xref="CDD:275376"
     Region          160..192
                     /region_name="YAF2_RYBP"
                     /note="Yaf2/RYBP C-terminal binding motif; pfam17219"
                     /db_xref="CDD:465386"
     CDS             1..238
                     /gene="YAF2"
                     /coded_by="XM_054370722.1:69..785"
                     /db_xref="GeneID:10138"
                     /db_xref="HGNC:HGNC:17363"
                     /db_xref="MIM:607534"
ORIGIN      
        1 mgdkksptrp krqpkpssde gywdcsvctf rnsaeafkcm mcdvrkgtst rmknheiisf
       61 lkegekkkld hlpvtgvlll gnlhrstlfe vivsasrtke plkfpisgrk prpvsqlvaq
      121 qvtqqfvppt qskkekkdkv ekeksekett skknshkktr prlknvdrss aqhlevtvgd
      181 ltviitdfke ktksppassa asadqhsqsg sssdntergm srsssprgea sslngesh
//
LOCUS       XP_054226698             182 aa            linear   PRI 05-AUG-2025
DEFINITION  YY1-associated factor 2 isoform X2 [Homo sapiens].
ACCESSION   XP_054226698
VERSION     XP_054226698.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370723.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..182
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..182
                     /product="YY1-associated factor 2 isoform X2"
                     /calculated_mol_wt=19800
     Region          104..136
                     /region_name="YAF2_RYBP"
                     /note="Yaf2/RYBP C-terminal binding motif; pfam17219"
                     /db_xref="CDD:465386"
     CDS             1..182
                     /gene="YAF2"
                     /coded_by="XM_054370723.1:102..650"
                     /db_xref="GeneID:10138"
                     /db_xref="HGNC:HGNC:17363"
                     /db_xref="MIM:607534"
ORIGIN      
        1 mcgrapppek kkldhlpvtg vlllgnlhrs tlfevivsas rtkeplkfpi sgrkprpvsq
       61 lvaqqvtqqf vpptqskkek kdkvekekse kettskknsh kktrprlknv drssaqhlev
      121 tvgdltviit dfkektkspp assaasadqh sqsgsssdnt ergmsrsssp rgeasslnge
      181 sh
//
LOCUS       XP_054226699             177 aa            linear   PRI 05-AUG-2025
DEFINITION  YY1-associated factor 2 isoform X3 [Homo sapiens].
ACCESSION   XP_054226699
VERSION     XP_054226699.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370724.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..177
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..177
                     /product="YY1-associated factor 2 isoform X3"
                     /calculated_mol_wt=19324
     Region          99..131
                     /region_name="YAF2_RYBP"
                     /note="Yaf2/RYBP C-terminal binding motif; pfam17219"
                     /db_xref="CDD:465386"
     CDS             1..177
                     /gene="YAF2"
                     /coded_by="XM_054370724.1:139..672"
                     /db_xref="GeneID:10138"
                     /db_xref="HGNC:HGNC:17363"
                     /db_xref="MIM:607534"
ORIGIN      
        1 mvcekkkldh lpvtgvlllg nlhrstlfev ivsasrtkep lkfpisgrkp rpvsqlvaqq
       61 vtqqfvpptq skkekkdkve kekseketts kknshkktrp rlknvdrssa qhlevtvgdl
      121 tviitdfkek tksppassaa sadqhsqsgs ssdntergms rsssprgeas slngesh
//
LOCUS       XP_054226700             159 aa            linear   PRI 05-AUG-2025
DEFINITION  YY1-associated factor 2 isoform X5 [Homo sapiens].
ACCESSION   XP_054226700
VERSION     XP_054226700.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370725.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..159
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..159
                     /product="YY1-associated factor 2 isoform X5"
                     /calculated_mol_wt=17204
     Region          81..113
                     /region_name="YAF2_RYBP"
                     /note="Yaf2/RYBP C-terminal binding motif; pfam17219"
                     /db_xref="CDD:465386"
     CDS             1..159
                     /gene="YAF2"
                     /coded_by="XM_054370725.1:137..616"
                     /db_xref="GeneID:10138"
                     /db_xref="HGNC:HGNC:17363"
                     /db_xref="MIM:607534"
ORIGIN      
        1 mvcgegstlf evivsasrtk eplkfpisgr kprpvsqlva qqvtqqfvpp tqskkekkdk
       61 vekekseket tskknshkkt rprlknvdrs saqhlevtvg dltviitdfk ektksppass
      121 aasadqhsqs gsssdnterg msrsssprge asslngesh
//
LOCUS       XP_054226701             120 aa            linear   PRI 05-AUG-2025
DEFINITION  YY1-associated factor 2 isoform X6 [Homo sapiens].
ACCESSION   XP_054226701
VERSION     XP_054226701.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370726.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..120
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..120
                     /product="YY1-associated factor 2 isoform X6"
                     /calculated_mol_wt=13210
     Region          20..43
                     /region_name="zf-RanBP"
                     /note="Zn-finger in Ran binding protein and others;
                     pfam00641"
                     /db_xref="CDD:395516"
     Region          23..42
                     /region_name="RanBP2-type Zn finger"
                     /note="RanBP2-type Zn finger [structural motif]"
                     /db_xref="CDD:275376"
     CDS             1..120
                     /gene="YAF2"
                     /coded_by="XM_054370726.1:69..431"
                     /db_xref="GeneID:10138"
                     /db_xref="HGNC:HGNC:17363"
                     /db_xref="MIM:607534"
ORIGIN      
        1 mgdkksptrp krqpkpssde gywdcsvctf rnsaeafkcm mcdvrkgtst rmknheiisf
       61 lkegekkkld hlpvtgvlll gnlhrstlfe vivsasrtke plkfpisgss sgcpsgrfsc
//
LOCUS       XP_054226702            1555 aa            linear   PRI 05-AUG-2025
DEFINITION  plexin-C1 isoform X1 [Homo sapiens].
ACCESSION   XP_054226702
VERSION     XP_054226702.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370727.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1555
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1555
                     /product="plexin-C1 isoform X1"
                     /calculated_mol_wt=174151
     Region          44..453
                     /region_name="Sema_plexin_C1"
                     /note="The Sema domain, a protein interacting module, of
                     Plexin C1; cd11246"
                     /db_xref="CDD:200507"
     Region          454..507
                     /region_name="PSI"
                     /note="Plexin repeat; pfam01437"
                     /db_xref="CDD:396154"
     Region          591..635
                     /region_name="PSI"
                     /note="domain found in Plexins, Semaphorins and Integrins;
                     smart00423"
                     /db_xref="CDD:214655"
     Region          664..750
                     /region_name="TIG"
                     /note="IPT/TIG domain; pfam01833"
                     /db_xref="CDD:460355"
     Region          754..840
                     /region_name="TIG"
                     /note="IPT/TIG domain; pfam01833"
                     /db_xref="CDD:460355"
     Region          1012..1517
                     /region_name="Plexin_cytopl"
                     /note="Plexin cytoplasmic RasGAP domain; pfam08337"
                     /db_xref="CDD:462434"
     CDS             1..1555
                     /gene="PLXNC1"
                     /gene_synonym="CD232; PLXN-C1; VESPR"
                     /coded_by="XM_054370727.1:396..5063"
                     /db_xref="GeneID:10154"
                     /db_xref="HGNC:HGNC:9106"
                     /db_xref="MIM:604259"
ORIGIN      
        1 mevsrrkapp rpprpaaplp llayllalaa pgrgadepvw rseqaigaia asqedgvfva
       61 sgscldqldy slehslsrly rdqagnctep vslapparpr pgssfsklll pyregaaglg
      121 gllltgwtfd rgacevrplg nlsrnslrng tevvschpqg stagvvyrag rnnrwylava
      181 atyvlpepet asrcnpaasd hdtaialkdt egrslatqel grlklcegag slhfvdaflw
      241 ngsiyfpyyp ynytsgaatg wpsmariaqs tevlfqgqas ldcghghpdg rrlllssslv
      301 ealdvwagvf saaagegqer rsptttalcl frmseiqara krvswdfkta eshckegdqp
      361 ervqpiasst lihsdltsvy gtvvmnrtvl flgtgdgqll kvilgenlts ncpeviyeik
      421 eetpvfyklv pdpvkniyiy ltagkevrri rvancnkhks csecltatdp hcgwchslqr
      481 ctfqgdcvhs enlenwldis sgakkcpkiq iirsskektt vtmvgsfspr hskcmvknvd
      541 ssrelcqnks qpnrtctcsi ptratykdvs vvnvmfsfgs wnlsdrfnft ncsslkecpa
      601 cvetgcawck sarrcihpft acdpsdyern qeqcpvavek tsgggrpken kgnrtnqalq
      661 vfyiksiepq kvstlgksnv ivtganftra snitmilkgt stcdkdviqv shvlndthmk
      721 fslpssrkem kdvciqfdgg ncssvgslsy ialphcslif pattwisggq nitmmgrnfd
      781 vidnliishe lkgninvsey cvatycgfla pslksskvrt nvtvklrvqd tyldcgtlqy
      841 redprftgyr vesevdtele vkiqkendnf niskkdieit lfhgengqln csfenitrnq
      901 dlttilckik giktastian sskkvrvklg nlelyveqes vpstwyfliv lpvllvivif
      961 aavgvtrhks kelsrkqsqq lelleselrk eirdgfaelq mdkldvvdsf gtvpfldykh
     1021 falrtffpen rdandknesl taldalicnk sflvtvihtl ekqknfsvkd rclfasflti
     1081 alqtklvylt silevltrdl meqcsnmqpk lmlrrtesvv eklltnwmsv clsgflretv
     1141 gepfyllvtt lnqkinkgpv dvitckalyt lnedwllwqv pefstvalnv vfekipenes
     1201 advcrnisvn vldcdtigqa kekifqafls kngspyglql neiglelqmg trqkelldid
     1261 sssviledgi tklntighye isngstikvf kkianftsdv eysddhchli lpdseafqdv
     1321 qgkrhrgkhk fkvkemyltk llstkvaihs vleklfrsiw slpnsrapfa ikyffdflda
     1381 qaenkkitdp dvvhiwktns lplrfwvnil knpqfvfdik ktphidgcls viaqafmdaf
     1441 slteqqlgke aptnkllyak diptykeevk syykairdlp plsssemeef ltqeskkhen
     1501 efneevalte iykyivkyfd eilnklerer gleeaqkqll hvkvlfdekk kckwm
//
LOCUS       XP_054226703            1375 aa            linear   PRI 05-AUG-2025
DEFINITION  plexin-C1 isoform X2 [Homo sapiens].
ACCESSION   XP_054226703
VERSION     XP_054226703.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370728.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1375
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1375
                     /product="plexin-C1 isoform X2"
                     /calculated_mol_wt=152623
     Region          44..453
                     /region_name="Sema_plexin_C1"
                     /note="The Sema domain, a protein interacting module, of
                     Plexin C1; cd11246"
                     /db_xref="CDD:200507"
     Region          454..507
                     /region_name="PSI"
                     /note="Plexin repeat; pfam01437"
                     /db_xref="CDD:396154"
     Region          591..635
                     /region_name="PSI"
                     /note="domain found in Plexins, Semaphorins and Integrins;
                     smart00423"
                     /db_xref="CDD:214655"
     Region          664..750
                     /region_name="TIG"
                     /note="IPT/TIG domain; pfam01833"
                     /db_xref="CDD:460355"
     Region          754..840
                     /region_name="TIG"
                     /note="IPT/TIG domain; pfam01833"
                     /db_xref="CDD:460355"
     Region          1012..>1358
                     /region_name="Plexin_cytopl"
                     /note="Plexin cytoplasmic RasGAP domain; pfam08337"
                     /db_xref="CDD:462434"
     CDS             1..1375
                     /gene="PLXNC1"
                     /gene_synonym="CD232; PLXN-C1; VESPR"
                     /coded_by="XM_054370728.1:396..4523"
                     /db_xref="GeneID:10154"
                     /db_xref="HGNC:HGNC:9106"
                     /db_xref="MIM:604259"
ORIGIN      
        1 mevsrrkapp rpprpaaplp llayllalaa pgrgadepvw rseqaigaia asqedgvfva
       61 sgscldqldy slehslsrly rdqagnctep vslapparpr pgssfsklll pyregaaglg
      121 gllltgwtfd rgacevrplg nlsrnslrng tevvschpqg stagvvyrag rnnrwylava
      181 atyvlpepet asrcnpaasd hdtaialkdt egrslatqel grlklcegag slhfvdaflw
      241 ngsiyfpyyp ynytsgaatg wpsmariaqs tevlfqgqas ldcghghpdg rrlllssslv
      301 ealdvwagvf saaagegqer rsptttalcl frmseiqara krvswdfkta eshckegdqp
      361 ervqpiasst lihsdltsvy gtvvmnrtvl flgtgdgqll kvilgenlts ncpeviyeik
      421 eetpvfyklv pdpvkniyiy ltagkevrri rvancnkhks csecltatdp hcgwchslqr
      481 ctfqgdcvhs enlenwldis sgakkcpkiq iirsskektt vtmvgsfspr hskcmvknvd
      541 ssrelcqnks qpnrtctcsi ptratykdvs vvnvmfsfgs wnlsdrfnft ncsslkecpa
      601 cvetgcawck sarrcihpft acdpsdyern qeqcpvavek tsgggrpken kgnrtnqalq
      661 vfyiksiepq kvstlgksnv ivtganftra snitmilkgt stcdkdviqv shvlndthmk
      721 fslpssrkem kdvciqfdgg ncssvgslsy ialphcslif pattwisggq nitmmgrnfd
      781 vidnliishe lkgninvsey cvatycgfla pslksskvrt nvtvklrvqd tyldcgtlqy
      841 redprftgyr vesevdtele vkiqkendnf niskkdieit lfhgengqln csfenitrnq
      901 dlttilckik giktastian sskkvrvklg nlelyveqes vpstwyfliv lpvllvivif
      961 aavgvtrhks kelsrkqsqq lelleselrk eirdgfaelq mdkldvvdsf gtvpfldykh
     1021 falrtffpes ggfthifted mhnrdandkn esltaldali cnksflvtvi htlekqknfs
     1081 vkdrclfasf ltialqtklv yltsilevlt rdlmeqcsnm qpklmlrrte svveklltnw
     1141 msvclsgflr etvgepfyll vttlnqkink gpvdvitcka lytlnedwll wqvpefstva
     1201 lnvvfekipe nesadvcrni svnvldcdti gqakekifqa flskngspyg lqlneiglel
     1261 qmgtrqkell didsssvile dgitklntig hyeisngsti kvfkkianft sdveysddhc
     1321 hlilpdseaf qdvqgkrhrg khkfkvkemy ltkllstkps ssllgkhpee psvcl
//
LOCUS       XP_054226704            1322 aa            linear   PRI 05-AUG-2025
DEFINITION  plexin-C1 isoform X3 [Homo sapiens].
ACCESSION   XP_054226704
VERSION     XP_054226704.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370729.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1322
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1322
                     /product="plexin-C1 isoform X3"
                     /calculated_mol_wt=146552
     Region          44..453
                     /region_name="Sema_plexin_C1"
                     /note="The Sema domain, a protein interacting module, of
                     Plexin C1; cd11246"
                     /db_xref="CDD:200507"
     Region          454..507
                     /region_name="PSI"
                     /note="Plexin repeat; pfam01437"
                     /db_xref="CDD:396154"
     Region          591..635
                     /region_name="PSI"
                     /note="domain found in Plexins, Semaphorins and Integrins;
                     smart00423"
                     /db_xref="CDD:214655"
     Region          664..750
                     /region_name="TIG"
                     /note="IPT/TIG domain; pfam01833"
                     /db_xref="CDD:460355"
     Region          754..840
                     /region_name="TIG"
                     /note="IPT/TIG domain; pfam01833"
                     /db_xref="CDD:460355"
     Region          1012..>1322
                     /region_name="Plexin_cytopl"
                     /note="Plexin cytoplasmic RasGAP domain; pfam08337"
                     /db_xref="CDD:462434"
     CDS             1..1322
                     /gene="PLXNC1"
                     /gene_synonym="CD232; PLXN-C1; VESPR"
                     /coded_by="XM_054370729.1:396..4364"
                     /db_xref="GeneID:10154"
                     /db_xref="HGNC:HGNC:9106"
                     /db_xref="MIM:604259"
ORIGIN      
        1 mevsrrkapp rpprpaaplp llayllalaa pgrgadepvw rseqaigaia asqedgvfva
       61 sgscldqldy slehslsrly rdqagnctep vslapparpr pgssfsklll pyregaaglg
      121 gllltgwtfd rgacevrplg nlsrnslrng tevvschpqg stagvvyrag rnnrwylava
      181 atyvlpepet asrcnpaasd hdtaialkdt egrslatqel grlklcegag slhfvdaflw
      241 ngsiyfpyyp ynytsgaatg wpsmariaqs tevlfqgqas ldcghghpdg rrlllssslv
      301 ealdvwagvf saaagegqer rsptttalcl frmseiqara krvswdfkta eshckegdqp
      361 ervqpiasst lihsdltsvy gtvvmnrtvl flgtgdgqll kvilgenlts ncpeviyeik
      421 eetpvfyklv pdpvkniyiy ltagkevrri rvancnkhks csecltatdp hcgwchslqr
      481 ctfqgdcvhs enlenwldis sgakkcpkiq iirsskektt vtmvgsfspr hskcmvknvd
      541 ssrelcqnks qpnrtctcsi ptratykdvs vvnvmfsfgs wnlsdrfnft ncsslkecpa
      601 cvetgcawck sarrcihpft acdpsdyern qeqcpvavek tsgggrpken kgnrtnqalq
      661 vfyiksiepq kvstlgksnv ivtganftra snitmilkgt stcdkdviqv shvlndthmk
      721 fslpssrkem kdvciqfdgg ncssvgslsy ialphcslif pattwisggq nitmmgrnfd
      781 vidnliishe lkgninvsey cvatycgfla pslksskvrt nvtvklrvqd tyldcgtlqy
      841 redprftgyr vesevdtele vkiqkendnf niskkdieit lfhgengqln csfenitrnq
      901 dlttilckik giktastian sskkvrvklg nlelyveqes vpstwyfliv lpvllvivif
      961 aavgvtrhks kelsrkqsqq lelleselrk eirdgfaelq mdkldvvdsf gtvpfldykh
     1021 falrtffpes ggfthifted mhnrdandkn esltaldali cnksflvtvi htlekqknfs
     1081 vkdrclfasf ltialqtklv yltsilevlt rdlmeqcsnm qpklmlrrte svveklltnw
     1141 msvclsgflr etvgepfyll vttlnqkink gpvdvitcka lytlnedwll wqvpefstva
     1201 lnvvfekipe nesadvcrni svnvldcdti gqakekifqa flskngspyg lqlneiglel
     1261 qmgtrqkell didsssvile dgitklntig hyesvkmtvt fiqrgplsgi walttptqqd
     1321 hs
//
LOCUS       XP_054226705            1036 aa            linear   PRI 05-AUG-2025
DEFINITION  plexin-C1 isoform X4 [Homo sapiens].
ACCESSION   XP_054226705
VERSION     XP_054226705.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370730.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1036
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1036
                     /product="plexin-C1 isoform X4"
                     /calculated_mol_wt=114229
     Region          44..453
                     /region_name="Sema_plexin_C1"
                     /note="The Sema domain, a protein interacting module, of
                     Plexin C1; cd11246"
                     /db_xref="CDD:200507"
     Region          454..507
                     /region_name="PSI"
                     /note="Plexin repeat; pfam01437"
                     /db_xref="CDD:396154"
     Region          591..635
                     /region_name="PSI"
                     /note="domain found in Plexins, Semaphorins and Integrins;
                     smart00423"
                     /db_xref="CDD:214655"
     Region          664..750
                     /region_name="TIG"
                     /note="IPT/TIG domain; pfam01833"
                     /db_xref="CDD:460355"
     Region          754..840
                     /region_name="TIG"
                     /note="IPT/TIG domain; pfam01833"
                     /db_xref="CDD:460355"
     Region          1010..>1029
                     /region_name="RasGAP"
                     /note="Ras GTPase Activating Domain; cl02569"
                     /db_xref="CDD:470620"
     CDS             1..1036
                     /gene="PLXNC1"
                     /gene_synonym="CD232; PLXN-C1; VESPR"
                     /coded_by="XM_054370730.1:396..3506"
                     /db_xref="GeneID:10154"
                     /db_xref="HGNC:HGNC:9106"
                     /db_xref="MIM:604259"
ORIGIN      
        1 mevsrrkapp rpprpaaplp llayllalaa pgrgadepvw rseqaigaia asqedgvfva
       61 sgscldqldy slehslsrly rdqagnctep vslapparpr pgssfsklll pyregaaglg
      121 gllltgwtfd rgacevrplg nlsrnslrng tevvschpqg stagvvyrag rnnrwylava
      181 atyvlpepet asrcnpaasd hdtaialkdt egrslatqel grlklcegag slhfvdaflw
      241 ngsiyfpyyp ynytsgaatg wpsmariaqs tevlfqgqas ldcghghpdg rrlllssslv
      301 ealdvwagvf saaagegqer rsptttalcl frmseiqara krvswdfkta eshckegdqp
      361 ervqpiasst lihsdltsvy gtvvmnrtvl flgtgdgqll kvilgenlts ncpeviyeik
      421 eetpvfyklv pdpvkniyiy ltagkevrri rvancnkhks csecltatdp hcgwchslqr
      481 ctfqgdcvhs enlenwldis sgakkcpkiq iirsskektt vtmvgsfspr hskcmvknvd
      541 ssrelcqnks qpnrtctcsi ptratykdvs vvnvmfsfgs wnlsdrfnft ncsslkecpa
      601 cvetgcawck sarrcihpft acdpsdyern qeqcpvavek tsgggrpken kgnrtnqalq
      661 vfyiksiepq kvstlgksnv ivtganftra snitmilkgt stcdkdviqv shvlndthmk
      721 fslpssrkem kdvciqfdgg ncssvgslsy ialphcslif pattwisggq nitmmgrnfd
      781 vidnliishe lkgninvsey cvatycgfla pslksskvrt nvtvklrvqd tyldcgtlqy
      841 redprftgyr vesevdtele vkiqkendnf niskkdieit lfhgengqln csfenitrnq
      901 dlttilckik giktastian sskkvrvklg nlelyveqes vpstwyfliv lpvllvivif
      961 aavgvtrhks kelsrkqsqq lelleselrk eirdgfaelq mdkldvvdsf gtvpfldykh
     1021 falrtffpeg seesst
//
LOCUS       XP_054226706             346 aa            linear   PRI 05-AUG-2025
DEFINITION  cyclin-dependent kinase 2 isoform X1 [Homo sapiens].
ACCESSION   XP_054226706
VERSION     XP_054226706.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370731.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..346
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..346
                     /product="cyclin-dependent kinase 2 isoform X1"
                     /calculated_mol_wt=39047
     Region          3..334
                     /region_name="STKc_CDK2_3"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     Cyclin-Dependent protein Kinase 2 and 3; cd07860"
                     /db_xref="CDD:270844"
     Site            order(10..13,18,31,33,50,64,80..83,86,88..89,127,129,
                     131..132,134,145,148,160,162..165,167,253..254)
                     /site_type="active"
                     /db_xref="CDD:270844"
     Site            order(10..13,18,31,33,64,80..83,86,89,131..132,134,145)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270844"
     Site            order(37,41..44,46,49..50,52..53,56..57,71..73,116,
                     119..122,150..152,154..155,157..160,320,324..326)
                     /site_type="other"
                     /note="CDK/cyclin interface [polypeptide binding]"
                     /db_xref="CDD:270844"
     Site            order(50,88,127,129,148,160,162..165,167,253..254)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270844"
     Site            144..167
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270844"
     CDS             1..346
                     /gene="CDK2"
                     /gene_synonym="CDKN2; p33(CDK2)"
                     /coded_by="XM_054370731.1:180..1220"
                     /db_xref="GeneID:1017"
                     /db_xref="HGNC:HGNC:1771"
                     /db_xref="MIM:116953"
ORIGIN      
        1 menfqkveki gegtygvvyk arnkltgevv alkkirldte tegvpstair eisllkelnh
       61 pnivklldvi htenklylvf eflhqdlkkf mdasaltgip lpliksylfq llqglafchs
      121 hrvlhrdlkp qnllintega ikladfglar afgvpvrtyt hevvtlwyra peillgckyy
      181 stavdiwslg cifaemhlvg tqhharccge hrrngrqslc plcsylevaa sqgwgmtavs
      241 tpypvtrral fpgdseidql frifrtlgtp devvwpgvts mpdykpsfpk warqdfskvv
      301 ppldedgrsl lsqmlhydpn krisakaala hpffqdvtkp vphlrl
//
LOCUS       XP_054226707             305 aa            linear   PRI 05-AUG-2025
DEFINITION  testis-expressed protein 52 isoform X1 [Homo sapiens].
ACCESSION   XP_054226707
VERSION     XP_054226707.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370732.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..305
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..305
                     /product="testis-expressed protein 52 isoform X1"
                     /calculated_mol_wt=35203
     Region          25..303
                     /region_name="DUF4532"
                     /note="Protein of unknown function (DUF4532); pfam15046"
                     /db_xref="CDD:464468"
     CDS             1..305
                     /gene="TEX52"
                     /coded_by="XM_054370732.1:14..931"
                     /db_xref="GeneID:101929469"
                     /db_xref="HGNC:HGNC:53643"
ORIGIN      
        1 masnrqrslr gpshpshmee pflqmvqase slppsqtwaq refflpsesw efpgftrqay
       61 hqlalklppc tdmkskvrqr lihpwkggaq htwgfhtwld vcrlpatfpt qpdrpydsnv
      121 wrwltdsnah rcpptehpip ppswmgqnsf ltfihcyptf vdmkrkkqvi frtvkelkev
      181 eklklrsear appldaqgni qppasfkkyr hisaggrfep qglqlmpnpf pnnfarswpc
      241 pnplphyqek vlklallpsa plsqdlirdf qtlikdrtal plhhlskaqa sksparkrkr
      301 rpghf
//
LOCUS       XP_054226708             201 aa            linear   PRI 05-AUG-2025
DEFINITION  E3 ubiquitin-protein ligase NRDP1 isoform X1 [Homo sapiens].
ACCESSION   XP_054226708
VERSION     XP_054226708.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370733.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..201
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..201
                     /product="E3 ubiquitin-protein ligase NRDP1 isoform X1"
                     /calculated_mol_wt=22772
     Region          15..57
                     /region_name="mRING-HC-C3HC3D_Nrdp1"
                     /note="Modified RING finger, HC subclass (C3HC3D-type),
                     found in neuregulin receptor degradation protein-1 (Nrdp1)
                     and similar proteins; cd16634"
                     /db_xref="CDD:438296"
     Region          137..>201
                     /region_name="USP8_interact"
                     /note="USP8 interacting; pfam08941"
                     /db_xref="CDD:430333"
     CDS             1..201
                     /gene="RNF41"
                     /gene_synonym="FLRF; NRDP1; SBBI03"
                     /coded_by="XM_054370733.1:372..977"
                     /db_xref="GeneID:10193"
                     /db_xref="HGNC:HGNC:18401"
                     /db_xref="MIM:620051"
ORIGIN      
        1 mgydvtrfqg dvdedlicpi csgvleepvq aphcehafcn acitqwfsqq qtcpvdrsvv
       61 tvahlrpvpr imrnmlsklq iacdnavfgc savvrldnlm shlsdcehnp krpvtceqgc
      121 glempkdelp nhncikhlrs vvqqqqtria elektsaehk hqlaeqkrdi qllkaymrai
      181 rsvnpnlqnl eetieyneil e
//
LOCUS       XP_054226709            1183 aa            linear   PRI 05-AUG-2025
DEFINITION  M-phase phosphoprotein 9 isoform X1 [Homo sapiens].
ACCESSION   XP_054226709
VERSION     XP_054226709.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370734.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1183
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1183
                     /product="M-phase phosphoprotein 9 isoform X1"
                     /calculated_mol_wt=132894
     Region          <592..>798
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1183
                     /gene="MPHOSPH9"
                     /gene_synonym="MPP-9; MPP9"
                     /coded_by="XM_054370734.1:226..3777"
                     /db_xref="GeneID:10198"
                     /db_xref="HGNC:HGNC:7215"
                     /db_xref="MIM:605501"
ORIGIN      
        1 meefdlvktl hktsssvgsd enslhslgln lntdrssphl stngvssfsg ktrpsviqgt
       61 vevltslmqe lqnsgktdse lwkncetrwl qlfnlvekqc qeqivaqqeq fhnqiqhiqe
      121 eiknlvklqt ssaslasceg nssnkqvsse sqmgffslss ernesvihyp estepeiqqe
      181 mstsqpdcnv dscsvssgyg tfciselnly kskdpkefme hidvpkgqyv apavpaeslv
      241 dgvknenfyi qtpeechvsl kedvsispge fehnflgenk vsevysgktn snaitswaqk
      301 lkqnqpkrah vedggsrskq gneqskktpi eksdfaaath prafylskpd etpnawmsds
      361 gtgltywkle ekdmhhslpe tlektfisls stdvspnqsn tsnemklpsl kdiyykkqre
      421 nkqlpernlt sasnpnhppe vltldptlhm kpkqqisgiq phglpnaldd risfspdsvl
      481 epsmsspsdi dsfsqasnvt sqlpgfpkyp shtkaspvds wknqtfqnes rtsstfpsvy
      541 titsndisvn tvdeentvmv asasvsqsql pgtansvpec isltsledpv ilskirqnlk
      601 ekharhiadl rayyeseins lkqkleakei sgvedwkitn qilvdrcgql dsalheatsr
      661 vrtlenknnl leievndlre rfsaassask ilqerieemr tsskekdnti irlksrlqdl
      721 eeafenaykl sddkeaqlkq enkmfqdllg eyeslgkehr rvkdalntte nklldaytqi
      781 sdlkrmiskl eaqvkqvehe nmlslrhnsr ihvrpsrant latsdvsrrk wlipgaeysi
      841 ftgqpldtqd snvdnqleet cslghrsple kdsspgssst sllikkqret sdtpimralk
      901 eldegkifkn wgtqtekedt sninprqtet svnasrspek caqqrqkrln sasqrssslp
      961 psnrksstpt kreimltpvt vayspkrspk enlspgfshl lsknesspir fdillddldt
     1021 vpvstlqrtn prkqlqflpl ddseektyse katdnhvnhs scpepvpngv kkvsvrtawe
     1081 knksvsyeqc kpvsvtpqgn dfeytakirt laeterffde ltkekdqiea alsrmpspgg
     1141 ritlqtrlnq ealedrleri nrelgsvrmt lkkfhvlrts anl
//
LOCUS       XP_054226710            1183 aa            linear   PRI 05-AUG-2025
DEFINITION  M-phase phosphoprotein 9 isoform X1 [Homo sapiens].
ACCESSION   XP_054226710
VERSION     XP_054226710.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370735.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1183
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1183
                     /product="M-phase phosphoprotein 9 isoform X1"
                     /calculated_mol_wt=132894
     Region          <592..>798
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1183
                     /gene="MPHOSPH9"
                     /gene_synonym="MPP-9; MPP9"
                     /coded_by="XM_054370735.1:226..3777"
                     /db_xref="GeneID:10198"
                     /db_xref="HGNC:HGNC:7215"
                     /db_xref="MIM:605501"
ORIGIN      
        1 meefdlvktl hktsssvgsd enslhslgln lntdrssphl stngvssfsg ktrpsviqgt
       61 vevltslmqe lqnsgktdse lwkncetrwl qlfnlvekqc qeqivaqqeq fhnqiqhiqe
      121 eiknlvklqt ssaslasceg nssnkqvsse sqmgffslss ernesvihyp estepeiqqe
      181 mstsqpdcnv dscsvssgyg tfciselnly kskdpkefme hidvpkgqyv apavpaeslv
      241 dgvknenfyi qtpeechvsl kedvsispge fehnflgenk vsevysgktn snaitswaqk
      301 lkqnqpkrah vedggsrskq gneqskktpi eksdfaaath prafylskpd etpnawmsds
      361 gtgltywkle ekdmhhslpe tlektfisls stdvspnqsn tsnemklpsl kdiyykkqre
      421 nkqlpernlt sasnpnhppe vltldptlhm kpkqqisgiq phglpnaldd risfspdsvl
      481 epsmsspsdi dsfsqasnvt sqlpgfpkyp shtkaspvds wknqtfqnes rtsstfpsvy
      541 titsndisvn tvdeentvmv asasvsqsql pgtansvpec isltsledpv ilskirqnlk
      601 ekharhiadl rayyeseins lkqkleakei sgvedwkitn qilvdrcgql dsalheatsr
      661 vrtlenknnl leievndlre rfsaassask ilqerieemr tsskekdnti irlksrlqdl
      721 eeafenaykl sddkeaqlkq enkmfqdllg eyeslgkehr rvkdalntte nklldaytqi
      781 sdlkrmiskl eaqvkqvehe nmlslrhnsr ihvrpsrant latsdvsrrk wlipgaeysi
      841 ftgqpldtqd snvdnqleet cslghrsple kdsspgssst sllikkqret sdtpimralk
      901 eldegkifkn wgtqtekedt sninprqtet svnasrspek caqqrqkrln sasqrssslp
      961 psnrksstpt kreimltpvt vayspkrspk enlspgfshl lsknesspir fdillddldt
     1021 vpvstlqrtn prkqlqflpl ddseektyse katdnhvnhs scpepvpngv kkvsvrtawe
     1081 knksvsyeqc kpvsvtpqgn dfeytakirt laeterffde ltkekdqiea alsrmpspgg
     1141 ritlqtrlnq ealedrleri nrelgsvrmt lkkfhvlrts anl
//
LOCUS       XP_054226711            1183 aa            linear   PRI 05-AUG-2025
DEFINITION  M-phase phosphoprotein 9 isoform X1 [Homo sapiens].
ACCESSION   XP_054226711
VERSION     XP_054226711.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370736.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1183
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1183
                     /product="M-phase phosphoprotein 9 isoform X1"
                     /calculated_mol_wt=132894
     Region          <592..>798
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1183
                     /gene="MPHOSPH9"
                     /gene_synonym="MPP-9; MPP9"
                     /coded_by="XM_054370736.1:975..4526"
                     /db_xref="GeneID:10198"
                     /db_xref="HGNC:HGNC:7215"
                     /db_xref="MIM:605501"
ORIGIN      
        1 meefdlvktl hktsssvgsd enslhslgln lntdrssphl stngvssfsg ktrpsviqgt
       61 vevltslmqe lqnsgktdse lwkncetrwl qlfnlvekqc qeqivaqqeq fhnqiqhiqe
      121 eiknlvklqt ssaslasceg nssnkqvsse sqmgffslss ernesvihyp estepeiqqe
      181 mstsqpdcnv dscsvssgyg tfciselnly kskdpkefme hidvpkgqyv apavpaeslv
      241 dgvknenfyi qtpeechvsl kedvsispge fehnflgenk vsevysgktn snaitswaqk
      301 lkqnqpkrah vedggsrskq gneqskktpi eksdfaaath prafylskpd etpnawmsds
      361 gtgltywkle ekdmhhslpe tlektfisls stdvspnqsn tsnemklpsl kdiyykkqre
      421 nkqlpernlt sasnpnhppe vltldptlhm kpkqqisgiq phglpnaldd risfspdsvl
      481 epsmsspsdi dsfsqasnvt sqlpgfpkyp shtkaspvds wknqtfqnes rtsstfpsvy
      541 titsndisvn tvdeentvmv asasvsqsql pgtansvpec isltsledpv ilskirqnlk
      601 ekharhiadl rayyeseins lkqkleakei sgvedwkitn qilvdrcgql dsalheatsr
      661 vrtlenknnl leievndlre rfsaassask ilqerieemr tsskekdnti irlksrlqdl
      721 eeafenaykl sddkeaqlkq enkmfqdllg eyeslgkehr rvkdalntte nklldaytqi
      781 sdlkrmiskl eaqvkqvehe nmlslrhnsr ihvrpsrant latsdvsrrk wlipgaeysi
      841 ftgqpldtqd snvdnqleet cslghrsple kdsspgssst sllikkqret sdtpimralk
      901 eldegkifkn wgtqtekedt sninprqtet svnasrspek caqqrqkrln sasqrssslp
      961 psnrksstpt kreimltpvt vayspkrspk enlspgfshl lsknesspir fdillddldt
     1021 vpvstlqrtn prkqlqflpl ddseektyse katdnhvnhs scpepvpngv kkvsvrtawe
     1081 knksvsyeqc kpvsvtpqgn dfeytakirt laeterffde ltkekdqiea alsrmpspgg
     1141 ritlqtrlnq ealedrleri nrelgsvrmt lkkfhvlrts anl
//
LOCUS       XP_054226712            1167 aa            linear   PRI 05-AUG-2025
DEFINITION  M-phase phosphoprotein 9 isoform X2 [Homo sapiens].
ACCESSION   XP_054226712
VERSION     XP_054226712.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370737.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1167
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1167
                     /product="M-phase phosphoprotein 9 isoform X2"
                     /calculated_mol_wt=131057
     Region          <592..>798
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1167
                     /gene="MPHOSPH9"
                     /gene_synonym="MPP-9; MPP9"
                     /coded_by="XM_054370737.1:226..3729"
                     /db_xref="GeneID:10198"
                     /db_xref="HGNC:HGNC:7215"
                     /db_xref="MIM:605501"
ORIGIN      
        1 meefdlvktl hktsssvgsd enslhslgln lntdrssphl stngvssfsg ktrpsviqgt
       61 vevltslmqe lqnsgktdse lwkncetrwl qlfnlvekqc qeqivaqqeq fhnqiqhiqe
      121 eiknlvklqt ssaslasceg nssnkqvsse sqmgffslss ernesvihyp estepeiqqe
      181 mstsqpdcnv dscsvssgyg tfciselnly kskdpkefme hidvpkgqyv apavpaeslv
      241 dgvknenfyi qtpeechvsl kedvsispge fehnflgenk vsevysgktn snaitswaqk
      301 lkqnqpkrah vedggsrskq gneqskktpi eksdfaaath prafylskpd etpnawmsds
      361 gtgltywkle ekdmhhslpe tlektfisls stdvspnqsn tsnemklpsl kdiyykkqre
      421 nkqlpernlt sasnpnhppe vltldptlhm kpkqqisgiq phglpnaldd risfspdsvl
      481 epsmsspsdi dsfsqasnvt sqlpgfpkyp shtkaspvds wknqtfqnes rtsstfpsvy
      541 titsndisvn tvdeentvmv asasvsqsql pgtansvpec isltsledpv ilskirqnlk
      601 ekharhiadl rayyeseins lkqkleakei sgvedwkitn qilvdrcgql dsalheatsr
      661 vrtlenknnl leievndlre rfsaassask ilqerieemr tsskekdnti irlksrlqdl
      721 eeafenaykl sddkeaqlkq enkmfqdllg eyeslgkehr rvkdalntte nklldaytqi
      781 sdlkrmiskl eaqvkqvehe nmlslrhnsr ihvrpsrant latsdvsrrk wlipgaeysi
      841 ftgqpldtqd snvdnqleet cslghrsple kdsspgssst sllikkqret sdtpimralk
      901 eldegkifkn wgtqtekedt sninprqtet svnasrspek caqqrqkrln sasqrssslp
      961 psnrksstpt kreimltpvt vayspkrspk enlspgfshl lsknesspir fdillddldt
     1021 vpvstlqrtn prkqlqflpl ddseektyse katdnhvnhs scpepvpngv kkvsvrtawe
     1081 knksvsyeqc kpvsvtpqgn dfeytakirt laeterffde ltkekdqiea alsrmpspgg
     1141 ritlqtrlnq fqilerlrwk dclspgv
//
LOCUS       XP_054226713            1151 aa            linear   PRI 05-AUG-2025
DEFINITION  M-phase phosphoprotein 9 isoform X3 [Homo sapiens].
ACCESSION   XP_054226713
VERSION     XP_054226713.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370738.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1151
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1151
                     /product="M-phase phosphoprotein 9 isoform X3"
                     /calculated_mol_wt=129128
     Region          <592..>798
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1151
                     /gene="MPHOSPH9"
                     /gene_synonym="MPP-9; MPP9"
                     /coded_by="XM_054370738.1:226..3681"
                     /db_xref="GeneID:10198"
                     /db_xref="HGNC:HGNC:7215"
                     /db_xref="MIM:605501"
ORIGIN      
        1 meefdlvktl hktsssvgsd enslhslgln lntdrssphl stngvssfsg ktrpsviqgt
       61 vevltslmqe lqnsgktdse lwkncetrwl qlfnlvekqc qeqivaqqeq fhnqiqhiqe
      121 eiknlvklqt ssaslasceg nssnkqvsse sqmgffslss ernesvihyp estepeiqqe
      181 mstsqpdcnv dscsvssgyg tfciselnly kskdpkefme hidvpkgqyv apavpaeslv
      241 dgvknenfyi qtpeechvsl kedvsispge fehnflgenk vsevysgktn snaitswaqk
      301 lkqnqpkrah vedggsrskq gneqskktpi eksdfaaath prafylskpd etpnawmsds
      361 gtgltywkle ekdmhhslpe tlektfisls stdvspnqsn tsnemklpsl kdiyykkqre
      421 nkqlpernlt sasnpnhppe vltldptlhm kpkqqisgiq phglpnaldd risfspdsvl
      481 epsmsspsdi dsfsqasnvt sqlpgfpkyp shtkaspvds wknqtfqnes rtsstfpsvy
      541 titsndisvn tvdeentvmv asasvsqsql pgtansvpec isltsledpv ilskirqnlk
      601 ekharhiadl rayyeseins lkqkleakei sgvedwkitn qilvdrcgql dsalheatsr
      661 vrtlenknnl leievndlre rfsaassask ilqerieemr tsskekdnti irlksrlqdl
      721 eeafenaykl sddkeaqlkq enkmfqdllg eyeslgkehr rvkdalntte nklldaytqi
      781 sdlkrmiskl eaqvkqvehe nmlslrhnsr ihvrpsrant latsdvsrrk wlipgaeysi
      841 ftgqpldtqd snvdnqleet cslghrsple kdsspgssst sllikkqret sdtpimralk
      901 eldegkifkn wgtqtekedt sninprqtet svnasrspek caqqrqkrln sasqrssslp
      961 psnrksstpt kreimltpvt vayspkrspk enlspgfshl lsknesspir fdillddldt
     1021 vpvstlqrtn prkqlqflpl ddseektyse katdnhvnhs scpepvpngv kkvsvrtawe
     1081 knksvsyeqc kpvsvtpqgn dfeytakirt laeterffde ltkekdqiea alsrmpspgg
     1141 ritlqtrlnq l
//
LOCUS       XP_054226714            1151 aa            linear   PRI 05-AUG-2025
DEFINITION  M-phase phosphoprotein 9 isoform X3 [Homo sapiens].
ACCESSION   XP_054226714
VERSION     XP_054226714.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370739.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1151
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1151
                     /product="M-phase phosphoprotein 9 isoform X3"
                     /calculated_mol_wt=129128
     Region          <592..>798
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1151
                     /gene="MPHOSPH9"
                     /gene_synonym="MPP-9; MPP9"
                     /coded_by="XM_054370739.1:226..3681"
                     /db_xref="GeneID:10198"
                     /db_xref="HGNC:HGNC:7215"
                     /db_xref="MIM:605501"
ORIGIN      
        1 meefdlvktl hktsssvgsd enslhslgln lntdrssphl stngvssfsg ktrpsviqgt
       61 vevltslmqe lqnsgktdse lwkncetrwl qlfnlvekqc qeqivaqqeq fhnqiqhiqe
      121 eiknlvklqt ssaslasceg nssnkqvsse sqmgffslss ernesvihyp estepeiqqe
      181 mstsqpdcnv dscsvssgyg tfciselnly kskdpkefme hidvpkgqyv apavpaeslv
      241 dgvknenfyi qtpeechvsl kedvsispge fehnflgenk vsevysgktn snaitswaqk
      301 lkqnqpkrah vedggsrskq gneqskktpi eksdfaaath prafylskpd etpnawmsds
      361 gtgltywkle ekdmhhslpe tlektfisls stdvspnqsn tsnemklpsl kdiyykkqre
      421 nkqlpernlt sasnpnhppe vltldptlhm kpkqqisgiq phglpnaldd risfspdsvl
      481 epsmsspsdi dsfsqasnvt sqlpgfpkyp shtkaspvds wknqtfqnes rtsstfpsvy
      541 titsndisvn tvdeentvmv asasvsqsql pgtansvpec isltsledpv ilskirqnlk
      601 ekharhiadl rayyeseins lkqkleakei sgvedwkitn qilvdrcgql dsalheatsr
      661 vrtlenknnl leievndlre rfsaassask ilqerieemr tsskekdnti irlksrlqdl
      721 eeafenaykl sddkeaqlkq enkmfqdllg eyeslgkehr rvkdalntte nklldaytqi
      781 sdlkrmiskl eaqvkqvehe nmlslrhnsr ihvrpsrant latsdvsrrk wlipgaeysi
      841 ftgqpldtqd snvdnqleet cslghrsple kdsspgssst sllikkqret sdtpimralk
      901 eldegkifkn wgtqtekedt sninprqtet svnasrspek caqqrqkrln sasqrssslp
      961 psnrksstpt kreimltpvt vayspkrspk enlspgfshl lsknesspir fdillddldt
     1021 vpvstlqrtn prkqlqflpl ddseektyse katdnhvnhs scpepvpngv kkvsvrtawe
     1081 knksvsyeqc kpvsvtpqgn dfeytakirt laeterffde ltkekdqiea alsrmpspgg
     1141 ritlqtrlnq l
//
LOCUS       XP_054226715            1149 aa            linear   PRI 05-AUG-2025
DEFINITION  M-phase phosphoprotein 9 isoform X4 [Homo sapiens].
ACCESSION   XP_054226715
VERSION     XP_054226715.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370740.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1149
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1149
                     /product="M-phase phosphoprotein 9 isoform X4"
                     /calculated_mol_wt=128833
     Region          <592..>791
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1149
                     /gene="MPHOSPH9"
                     /gene_synonym="MPP-9; MPP9"
                     /coded_by="XM_054370740.1:226..3675"
                     /db_xref="GeneID:10198"
                     /db_xref="HGNC:HGNC:7215"
                     /db_xref="MIM:605501"
ORIGIN      
        1 meefdlvktl hktsssvgsd enslhslgln lntdrssphl stngvssfsg ktrpsviqgt
       61 vevltslmqe lqnsgktdse lwkncetrwl qlfnlvekqc qeqivaqqeq fhnqiqhiqe
      121 eiknlvklqt ssaslasceg nssnkqvsse sqmgffslss ernesvihyp estepeiqqe
      181 mstsqpdcnv dscsvssgyg tfciselnly kskdpkefme hidvpkgqyv apavpaeslv
      241 dgvknenfyi qtpeechvsl kedvsispge fehnflgenk vsevysgktn snaitswaqk
      301 lkqnqpkrah vedggsrskq gneqskktpi eksdfaaath prafylskpd etpnawmsds
      361 gtgltywkle ekdmhhslpe tlektfisls stdvspnqsn tsnemklpsl kdiyykkqre
      421 nkqlpernlt sasnpnhppe vltldptlhm kpkqqisgiq phglpnaldd risfspdsvl
      481 epsmsspsdi dsfsqasnvt sqlpgfpkyp shtkaspvds wknqtfqnes rtsstfpsvy
      541 titsndisvn tvdeentvmv asasvsqsql pgtansvpec isltsledpv ilskirqnlk
      601 ekharhiadl rayyeseins lkqkleakei sgvedwkitn qilvdrcgql dsalheatsr
      661 vrtlenknnl leievndlre rfsaassask ilqerieemr tsskekdnti irlksrlqdl
      721 eeafenaykl sddkeaqlkq enkmfqdllg eyeslgkehr rvkdalntte nklldaytqi
      781 sdlkstlats dvsrrkwlip gaeysiftgq pldtqdsnvd nqleetcslg hrsplekdss
      841 pgssstslli kkqretsdtp imralkelde gkifknwgtq tekedtsnin prqtetsvna
      901 srspekcaqq rqkrlnsasq rssslppsnr ksstptkrei mltpvtvays pkrspkenls
      961 pgfshllskn esspirfdil lddldtvpvs tlqrtnprkq lqflplddse ektysekatd
     1021 nhvnhsscpe pvpngvkkvs vrtaweknks vsyeqckpvs vtpqgndfey takirtlaet
     1081 erffdeltke kdqieaalsr mpspggritl qtrlnqeale drlerinrel gsvrmtlkkf
     1141 hvlrtsanl
//
LOCUS       XP_054226716            1141 aa            linear   PRI 05-AUG-2025
DEFINITION  M-phase phosphoprotein 9 isoform X5 [Homo sapiens].
ACCESSION   XP_054226716
VERSION     XP_054226716.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370741.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1141
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1141
                     /product="M-phase phosphoprotein 9 isoform X5"
                     /calculated_mol_wt=128013
     Region          <550..>756
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1141
                     /gene="MPHOSPH9"
                     /gene_synonym="MPP-9; MPP9"
                     /coded_by="XM_054370741.1:226..3651"
                     /db_xref="GeneID:10198"
                     /db_xref="HGNC:HGNC:7215"
                     /db_xref="MIM:605501"
ORIGIN      
        1 meefdlvktl hktsssvgsd enslhslgln lntdrssphl stngvssfsg ktrpsviqgt
       61 vevltslmqe lqnsgktdse lwkncetrwl qlfnlvekqc qeqivaqqeq fhnqiqhiqe
      121 eiknlvklqt ssaslasceg nssnkqvsse sqmgffslss ernesvihyp estepeiqqe
      181 mstsqpdcnv dscsvssgyg tfciselnly kskdpkefme hidvpkgqyv apavpaeslv
      241 dgvknenfyi qtpeechvsl kedvsispge fehnflgenk vsevysgktn snaitswaqk
      301 lkqnqpkrah vedggsrskq gneqskktpi eksdfaaath prafylskpd etpnawmsds
      361 gtgltywkle ekdmhhslpe tlektfisls stdvspnqvl tldptlhmkp kqqisgiqph
      421 glpnalddri sfspdsvlep smsspsdids fsqasnvtsq lpgfpkypsh tkaspvdswk
      481 nqtfqnesrt sstfpsvyti tsndisvntv deentvmvas asvsqsqlpg tansvpecis
      541 ltsledpvil skirqnlkek harhiadlra yyeseinslk qkleakeisg vedwkitnqi
      601 lvdrcgqlds alheatsrvr tlenknnlle ievndlrerf saassaskil qerieemrts
      661 skekdntiir lksrlqdlee afenayklsd dkeaqlkqen kmfqdllgey eslgkehrrv
      721 kdalnttenk lldaytqisd lkrmisklea qvkqvehenm lslrhnsrih vrpsrantla
      781 tsdvsrrkwl ipgaeysift gqpldtqdsn vdnqleetcs lghrsplekd sspgssstsl
      841 likkqretsd tpimralkel degkifknwg tqtekedtsn inprqtetsv nasrspekca
      901 qqrqkrlnsa sqrssslpps nrksstptkr eimltpvtva yspkrspken lspgfshlls
      961 knesspirfd illddldtvp vstlqrtnpr kqlqflpldd seektyseka tdnhvnhssc
     1021 pepvpngvkk vsvrtawekn ksvsyeqckp vsvtpqgndf eytakirtla eterffdelt
     1081 kekdqieaal srmpspggri tlqtrlnqea ledrlerinr elgsvrmtlk kfhvlrtsan
     1141 l
//
LOCUS       XP_054226717            1141 aa            linear   PRI 05-AUG-2025
DEFINITION  M-phase phosphoprotein 9 isoform X5 [Homo sapiens].
ACCESSION   XP_054226717
VERSION     XP_054226717.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370742.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1141
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1141
                     /product="M-phase phosphoprotein 9 isoform X5"
                     /calculated_mol_wt=128013
     Region          <550..>756
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1141
                     /gene="MPHOSPH9"
                     /gene_synonym="MPP-9; MPP9"
                     /coded_by="XM_054370742.1:226..3651"
                     /db_xref="GeneID:10198"
                     /db_xref="HGNC:HGNC:7215"
                     /db_xref="MIM:605501"
ORIGIN      
        1 meefdlvktl hktsssvgsd enslhslgln lntdrssphl stngvssfsg ktrpsviqgt
       61 vevltslmqe lqnsgktdse lwkncetrwl qlfnlvekqc qeqivaqqeq fhnqiqhiqe
      121 eiknlvklqt ssaslasceg nssnkqvsse sqmgffslss ernesvihyp estepeiqqe
      181 mstsqpdcnv dscsvssgyg tfciselnly kskdpkefme hidvpkgqyv apavpaeslv
      241 dgvknenfyi qtpeechvsl kedvsispge fehnflgenk vsevysgktn snaitswaqk
      301 lkqnqpkrah vedggsrskq gneqskktpi eksdfaaath prafylskpd etpnawmsds
      361 gtgltywkle ekdmhhslpe tlektfisls stdvspnqvl tldptlhmkp kqqisgiqph
      421 glpnalddri sfspdsvlep smsspsdids fsqasnvtsq lpgfpkypsh tkaspvdswk
      481 nqtfqnesrt sstfpsvyti tsndisvntv deentvmvas asvsqsqlpg tansvpecis
      541 ltsledpvil skirqnlkek harhiadlra yyeseinslk qkleakeisg vedwkitnqi
      601 lvdrcgqlds alheatsrvr tlenknnlle ievndlrerf saassaskil qerieemrts
      661 skekdntiir lksrlqdlee afenayklsd dkeaqlkqen kmfqdllgey eslgkehrrv
      721 kdalnttenk lldaytqisd lkrmisklea qvkqvehenm lslrhnsrih vrpsrantla
      781 tsdvsrrkwl ipgaeysift gqpldtqdsn vdnqleetcs lghrsplekd sspgssstsl
      841 likkqretsd tpimralkel degkifknwg tqtekedtsn inprqtetsv nasrspekca
      901 qqrqkrlnsa sqrssslpps nrksstptkr eimltpvtva yspkrspken lspgfshlls
      961 knesspirfd illddldtvp vstlqrtnpr kqlqflpldd seektyseka tdnhvnhssc
     1021 pepvpngvkk vsvrtawekn ksvsyeqckp vsvtpqgndf eytakirtla eterffdelt
     1081 kekdqieaal srmpspggri tlqtrlnqea ledrlerinr elgsvrmtlk kfhvlrtsan
     1141 l
//
LOCUS       XP_054226718            1131 aa            linear   PRI 05-AUG-2025
DEFINITION  M-phase phosphoprotein 9 isoform X6 [Homo sapiens].
ACCESSION   XP_054226718
VERSION     XP_054226718.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370743.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1131
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1131
                     /product="M-phase phosphoprotein 9 isoform X6"
                     /calculated_mol_wt=126719
     Region          602..>748
                     /region_name="DR0291"
                     /note="Predicted nucleic acid-binding protein DR0291,
                     contains C4-type Zn-ribbon domain [General function
                     prediction only]; COG1579"
                     /db_xref="CDD:441187"
     CDS             1..1131
                     /gene="MPHOSPH9"
                     /gene_synonym="MPP-9; MPP9"
                     /coded_by="XM_054370743.1:226..3621"
                     /db_xref="GeneID:10198"
                     /db_xref="HGNC:HGNC:7215"
                     /db_xref="MIM:605501"
ORIGIN      
        1 meefdlvktl hktsssvgsd enslhslgln lntdrssphl stngvssfsg ktrpsviqgt
       61 vevltslmqe lqnsgktdse lwkncetrwl qlfnlvekqc qeqivaqqeq fhnqiqhiqe
      121 eiknlvklqt ssaslasceg nssnkqvsse sqmgffslss ernesvihyp estepeiqqe
      181 mstsqpdcnv dscsvssgyg tfciselnly kskdpkefme hidvpkgqyv apavpaeslv
      241 dgvknenfyi qtpeechvsl kedvsispge fehnflgenk vsevysgktn snaitswaqk
      301 lkqnqpkrah vedggsrskq gneqskktpi eksdfaaath prafylskpd etpnawmsds
      361 gtgltywkle ekdmhhslpe tlektfisls stdvspnqsn tsnemklpsl kdiyykkqre
      421 nkqlpernlt sasnpnhppe vltldptlhm kpkqqisgiq phglpnaldd risfspdsvl
      481 epsmsspsdi dsfsqasnvt sqlpgfpkyp shtkaspvds wknqtfqnes rtsstfpsvy
      541 titsndisvn tvdeentvmv asasvsqsql pgtansvpec isltsledpv ilskcgqlds
      601 alheatsrvr tlenknnlle ievndlrerf saassaskil qerieemrts skekdntiir
      661 lksrlqdlee afenayklsd dkeaqlkqen kmfqdllgey eslgkehrrv kdalnttenk
      721 lldaytqisd lkrmisklea qvkqvehenm lslrhnsrih vrpsrantla tsdvsrrkwl
      781 ipgaeysift gqpldtqdsn vdnqleetcs lghrsplekd sspgssstsl likkqretsd
      841 tpimralkel degkifknwg tqtekedtsn inprqtetsv nasrspekca qqrqkrlnsa
      901 sqrssslpps nrksstptkr eimltpvtva yspkrspken lspgfshlls knesspirfd
      961 illddldtvp vstlqrtnpr kqlqflpldd seektyseka tdnhvnhssc pepvpngvkk
     1021 vsvrtawekn ksvsyeqckp vsvtpqgndf eytakirtla eterffdelt kekdqieaal
     1081 srmpspggri tlqtrlnqea ledrlerinr elgsvrmtlk kfhvlrtsan l
//
LOCUS       XP_054226719            1125 aa            linear   PRI 05-AUG-2025
DEFINITION  M-phase phosphoprotein 9 isoform X7 [Homo sapiens].
ACCESSION   XP_054226719
VERSION     XP_054226719.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370744.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1125
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1125
                     /product="M-phase phosphoprotein 9 isoform X7"
                     /calculated_mol_wt=126177
     Region          <550..>756
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1125
                     /gene="MPHOSPH9"
                     /gene_synonym="MPP-9; MPP9"
                     /coded_by="XM_054370744.1:226..3603"
                     /db_xref="GeneID:10198"
                     /db_xref="HGNC:HGNC:7215"
                     /db_xref="MIM:605501"
ORIGIN      
        1 meefdlvktl hktsssvgsd enslhslgln lntdrssphl stngvssfsg ktrpsviqgt
       61 vevltslmqe lqnsgktdse lwkncetrwl qlfnlvekqc qeqivaqqeq fhnqiqhiqe
      121 eiknlvklqt ssaslasceg nssnkqvsse sqmgffslss ernesvihyp estepeiqqe
      181 mstsqpdcnv dscsvssgyg tfciselnly kskdpkefme hidvpkgqyv apavpaeslv
      241 dgvknenfyi qtpeechvsl kedvsispge fehnflgenk vsevysgktn snaitswaqk
      301 lkqnqpkrah vedggsrskq gneqskktpi eksdfaaath prafylskpd etpnawmsds
      361 gtgltywkle ekdmhhslpe tlektfisls stdvspnqvl tldptlhmkp kqqisgiqph
      421 glpnalddri sfspdsvlep smsspsdids fsqasnvtsq lpgfpkypsh tkaspvdswk
      481 nqtfqnesrt sstfpsvyti tsndisvntv deentvmvas asvsqsqlpg tansvpecis
      541 ltsledpvil skirqnlkek harhiadlra yyeseinslk qkleakeisg vedwkitnqi
      601 lvdrcgqlds alheatsrvr tlenknnlle ievndlrerf saassaskil qerieemrts
      661 skekdntiir lksrlqdlee afenayklsd dkeaqlkqen kmfqdllgey eslgkehrrv
      721 kdalnttenk lldaytqisd lkrmisklea qvkqvehenm lslrhnsrih vrpsrantla
      781 tsdvsrrkwl ipgaeysift gqpldtqdsn vdnqleetcs lghrsplekd sspgssstsl
      841 likkqretsd tpimralkel degkifknwg tqtekedtsn inprqtetsv nasrspekca
      901 qqrqkrlnsa sqrssslpps nrksstptkr eimltpvtva yspkrspken lspgfshlls
      961 knesspirfd illddldtvp vstlqrtnpr kqlqflpldd seektyseka tdnhvnhssc
     1021 pepvpngvkk vsvrtawekn ksvsyeqckp vsvtpqgndf eytakirtla eterffdelt
     1081 kekdqieaal srmpspggri tlqtrlnqfq ilerlrwkdc lspgv
//
LOCUS       XP_054226720            1116 aa            linear   PRI 05-AUG-2025
DEFINITION  M-phase phosphoprotein 9 isoform X8 [Homo sapiens].
ACCESSION   XP_054226720
VERSION     XP_054226720.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370745.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1116
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1116
                     /product="M-phase phosphoprotein 9 isoform X8"
                     /calculated_mol_wt=125781
     Region          <525..>731
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1116
                     /gene="MPHOSPH9"
                     /gene_synonym="MPP-9; MPP9"
                     /coded_by="XM_054370745.1:139..3489"
                     /db_xref="GeneID:10198"
                     /db_xref="HGNC:HGNC:7215"
                     /db_xref="MIM:605501"
ORIGIN      
        1 mqelqnsgkt dselwkncet rwlqlfnlve kqcqeqivaq qeqfhnqiqh iqeeiknlvk
       61 lqtssaslas cegnssnkqv ssesqmgffs lssernesvi hypestepei qqemstsqpd
      121 cnvdscsvss gygtfcisel nlykskdpke fmehidvpkg qyvapavpae slvdgvknen
      181 fyiqtpeech vslkedvsis pgefehnflg enkvsevysg ktnsnaitsw aqklkqnqpk
      241 rahvedggsr skqgneqskk tpieksdfaa athprafyls kpdetpnawm sdsgtgltyw
      301 kleekdmhhs lpetlektfi slsstdvspn qsntsnemkl pslkdiyykk qrenkqlper
      361 nltsasnpnh ppevltldpt lhmkpkqqis giqphglpna lddrisfspd svlepsmssp
      421 sdidsfsqas nvtsqlpgfp kypshtkasp vdswknqtfq nesrtsstfp svytitsndi
      481 svntvdeent vmvasasvsq sqlpgtansv pecisltsle dpvilskirq nlkekharhi
      541 adlrayyese inslkqklea keisgvedwk itnqilvdrc gqldsalhea tsrvrtlenk
      601 nnlleievnd lrerfsaass askilqerie emrtsskekd ntiirlksrl qdleeafena
      661 yklsddkeaq lkqenkmfqd llgeyeslgk ehrrvkdaln ttenkllday tqisdlkrmi
      721 skleaqvkqv ehenmlslrh nsrihvrpsr antlatsdvs rrkwlipgae ysiftgqpld
      781 tqdsnvdnql eetcslghrs plekdsspgs sstsllikkq retsdtpimr alkeldegki
      841 fknwgtqtek edtsninprq tetsvnasrs pekcaqqrqk rlnsasqrss slppsnrkss
      901 tptkreimlt pvtvayspkr spkenlspgf shllskness pirfdilldd ldtvpvstlq
      961 rtnprkqlqf lplddseekt ysekatdnhv nhsscpepvp ngvkkvsvrt aweknksvsy
     1021 eqckpvsvtp qgndfeytak irtlaeterf fdeltkekdq ieaalsrmps pggritlqtr
     1081 lnqealedrl erinrelgsv rmtlkkfhvl rtsanl
//
LOCUS       XP_054226721            1109 aa            linear   PRI 05-AUG-2025
DEFINITION  M-phase phosphoprotein 9 isoform X9 [Homo sapiens].
ACCESSION   XP_054226721
VERSION     XP_054226721.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370746.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1109
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1109
                     /product="M-phase phosphoprotein 9 isoform X9"
                     /calculated_mol_wt=124248
     Region          <550..>756
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1109
                     /gene="MPHOSPH9"
                     /gene_synonym="MPP-9; MPP9"
                     /coded_by="XM_054370746.1:226..3555"
                     /db_xref="GeneID:10198"
                     /db_xref="HGNC:HGNC:7215"
                     /db_xref="MIM:605501"
ORIGIN      
        1 meefdlvktl hktsssvgsd enslhslgln lntdrssphl stngvssfsg ktrpsviqgt
       61 vevltslmqe lqnsgktdse lwkncetrwl qlfnlvekqc qeqivaqqeq fhnqiqhiqe
      121 eiknlvklqt ssaslasceg nssnkqvsse sqmgffslss ernesvihyp estepeiqqe
      181 mstsqpdcnv dscsvssgyg tfciselnly kskdpkefme hidvpkgqyv apavpaeslv
      241 dgvknenfyi qtpeechvsl kedvsispge fehnflgenk vsevysgktn snaitswaqk
      301 lkqnqpkrah vedggsrskq gneqskktpi eksdfaaath prafylskpd etpnawmsds
      361 gtgltywkle ekdmhhslpe tlektfisls stdvspnqvl tldptlhmkp kqqisgiqph
      421 glpnalddri sfspdsvlep smsspsdids fsqasnvtsq lpgfpkypsh tkaspvdswk
      481 nqtfqnesrt sstfpsvyti tsndisvntv deentvmvas asvsqsqlpg tansvpecis
      541 ltsledpvil skirqnlkek harhiadlra yyeseinslk qkleakeisg vedwkitnqi
      601 lvdrcgqlds alheatsrvr tlenknnlle ievndlrerf saassaskil qerieemrts
      661 skekdntiir lksrlqdlee afenayklsd dkeaqlkqen kmfqdllgey eslgkehrrv
      721 kdalnttenk lldaytqisd lkrmisklea qvkqvehenm lslrhnsrih vrpsrantla
      781 tsdvsrrkwl ipgaeysift gqpldtqdsn vdnqleetcs lghrsplekd sspgssstsl
      841 likkqretsd tpimralkel degkifknwg tqtekedtsn inprqtetsv nasrspekca
      901 qqrqkrlnsa sqrssslpps nrksstptkr eimltpvtva yspkrspken lspgfshlls
      961 knesspirfd illddldtvp vstlqrtnpr kqlqflpldd seektyseka tdnhvnhssc
     1021 pepvpngvkk vsvrtawekn ksvsyeqckp vsvtpqgndf eytakirtla eterffdelt
     1081 kekdqieaal srmpspggri tlqtrlnql
//
LOCUS       XP_054226722            1108 aa            linear   PRI 05-AUG-2025
DEFINITION  M-phase phosphoprotein 9 isoform X10 [Homo sapiens].
ACCESSION   XP_054226722
VERSION     XP_054226722.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370747.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1108
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1108
                     /product="M-phase phosphoprotein 9 isoform X10"
                     /calculated_mol_wt=124388
     Region          <592..>798
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1108
                     /gene="MPHOSPH9"
                     /gene_synonym="MPP-9; MPP9"
                     /coded_by="XM_054370747.1:226..3552"
                     /db_xref="GeneID:10198"
                     /db_xref="HGNC:HGNC:7215"
                     /db_xref="MIM:605501"
ORIGIN      
        1 meefdlvktl hktsssvgsd enslhslgln lntdrssphl stngvssfsg ktrpsviqgt
       61 vevltslmqe lqnsgktdse lwkncetrwl qlfnlvekqc qeqivaqqeq fhnqiqhiqe
      121 eiknlvklqt ssaslasceg nssnkqvsse sqmgffslss ernesvihyp estepeiqqe
      181 mstsqpdcnv dscsvssgyg tfciselnly kskdpkefme hidvpkgqyv apavpaeslv
      241 dgvknenfyi qtpeechvsl kedvsispge fehnflgenk vsevysgktn snaitswaqk
      301 lkqnqpkrah vedggsrskq gneqskktpi eksdfaaath prafylskpd etpnawmsds
      361 gtgltywkle ekdmhhslpe tlektfisls stdvspnqsn tsnemklpsl kdiyykkqre
      421 nkqlpernlt sasnpnhppe vltldptlhm kpkqqisgiq phglpnaldd risfspdsvl
      481 epsmsspsdi dsfsqasnvt sqlpgfpkyp shtkaspvds wknqtfqnes rtsstfpsvy
      541 titsndisvn tvdeentvmv asasvsqsql pgtansvpec isltsledpv ilskirqnlk
      601 ekharhiadl rayyeseins lkqkleakei sgvedwkitn qilvdrcgql dsalheatsr
      661 vrtlenknnl leievndlre rfsaassask ilqerieemr tsskekdnti irlksrlqdl
      721 eeafenaykl sddkeaqlkq enkmfqdllg eyeslgkehr rvkdalntte nklldaytqi
      781 sdlkrmiskl eaqvkqvehe nmlslrhnsr ihvrpsrant latsdvsrrk wlipgaeysi
      841 ftgqpldtqd snvdnqleet cslghrsple kdsspgssst sllikkqret sdtpimralk
      901 eldegkifkn wgtqtekedt sninprqtet svnasrspek caqqrqkrln sasqrssslp
      961 psnrksstpk ktysekatdn hvnhsscpep vpngvkkvsv rtaweknksv syeqckpvsv
     1021 tpqgndfeyt akirtlaete rffdeltkek dqieaalsrm pspggritlq trlnqealed
     1081 rlerinrelg svrmtlkkfh vlrtsanl
//
LOCUS       XP_054226723            1107 aa            linear   PRI 05-AUG-2025
DEFINITION  M-phase phosphoprotein 9 isoform X11 [Homo sapiens].
ACCESSION   XP_054226723
VERSION     XP_054226723.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370748.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1107
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1107
                     /product="M-phase phosphoprotein 9 isoform X11"
                     /calculated_mol_wt=123952
     Region          <550..>749
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1107
                     /gene="MPHOSPH9"
                     /gene_synonym="MPP-9; MPP9"
                     /coded_by="XM_054370748.1:226..3549"
                     /db_xref="GeneID:10198"
                     /db_xref="HGNC:HGNC:7215"
                     /db_xref="MIM:605501"
ORIGIN      
        1 meefdlvktl hktsssvgsd enslhslgln lntdrssphl stngvssfsg ktrpsviqgt
       61 vevltslmqe lqnsgktdse lwkncetrwl qlfnlvekqc qeqivaqqeq fhnqiqhiqe
      121 eiknlvklqt ssaslasceg nssnkqvsse sqmgffslss ernesvihyp estepeiqqe
      181 mstsqpdcnv dscsvssgyg tfciselnly kskdpkefme hidvpkgqyv apavpaeslv
      241 dgvknenfyi qtpeechvsl kedvsispge fehnflgenk vsevysgktn snaitswaqk
      301 lkqnqpkrah vedggsrskq gneqskktpi eksdfaaath prafylskpd etpnawmsds
      361 gtgltywkle ekdmhhslpe tlektfisls stdvspnqvl tldptlhmkp kqqisgiqph
      421 glpnalddri sfspdsvlep smsspsdids fsqasnvtsq lpgfpkypsh tkaspvdswk
      481 nqtfqnesrt sstfpsvyti tsndisvntv deentvmvas asvsqsqlpg tansvpecis
      541 ltsledpvil skirqnlkek harhiadlra yyeseinslk qkleakeisg vedwkitnqi
      601 lvdrcgqlds alheatsrvr tlenknnlle ievndlrerf saassaskil qerieemrts
      661 skekdntiir lksrlqdlee afenayklsd dkeaqlkqen kmfqdllgey eslgkehrrv
      721 kdalnttenk lldaytqisd lkstlatsdv srrkwlipga eysiftgqpl dtqdsnvdnq
      781 leetcslghr splekdsspg ssstsllikk qretsdtpim ralkeldegk ifknwgtqte
      841 kedtsninpr qtetsvnasr spekcaqqrq krlnsasqrs sslppsnrks stptkreiml
      901 tpvtvayspk rspkenlspg fshllsknes spirfdilld dldtvpvstl qrtnprkqlq
      961 flplddseek tysekatdnh vnhsscpepv pngvkkvsvr taweknksvs yeqckpvsvt
     1021 pqgndfeyta kirtlaeter ffdeltkekd qieaalsrmp spggritlqt rlnqealedr
     1081 lerinrelgs vrmtlkkfhv lrtsanl
//
LOCUS       XP_054226724            1089 aa            linear   PRI 05-AUG-2025
DEFINITION  M-phase phosphoprotein 9 isoform X12 [Homo sapiens].
ACCESSION   XP_054226724
VERSION     XP_054226724.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370749.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1089
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1089
                     /product="M-phase phosphoprotein 9 isoform X12"
                     /calculated_mol_wt=121839
     Region          <558..>717
                     /region_name="Mplasa_alph_rch"
                     /note="helix-rich Mycoplasma protein; TIGR04523"
                     /db_xref="CDD:275316"
     CDS             1..1089
                     /gene="MPHOSPH9"
                     /gene_synonym="MPP-9; MPP9"
                     /coded_by="XM_054370749.1:226..3495"
                     /db_xref="GeneID:10198"
                     /db_xref="HGNC:HGNC:7215"
                     /db_xref="MIM:605501"
ORIGIN      
        1 meefdlvktl hktsssvgsd enslhslgln lntdrssphl stngvssfsg ktrpsviqgt
       61 vevltslmqe lqnsgktdse lwkncetrwl qlfnlvekqc qeqivaqqeq fhnqiqhiqe
      121 eiknlvklqt ssaslasceg nssnkqvsse sqmgffslss ernesvihyp estepeiqqe
      181 mstsqpdcnv dscsvssgyg tfciselnly kskdpkefme hidvpkgqyv apavpaeslv
      241 dgvknenfyi qtpeechvsl kedvsispge fehnflgenk vsevysgktn snaitswaqk
      301 lkqnqpkrah vedggsrskq gneqskktpi eksdfaaath prafylskpd etpnawmsds
      361 gtgltywkle ekdmhhslpe tlektfisls stdvspnqvl tldptlhmkp kqqisgiqph
      421 glpnalddri sfspdsvlep smsspsdids fsqasnvtsq lpgfpkypsh tkaspvdswk
      481 nqtfqnesrt sstfpsvyti tsndisvntv deentvmvas asvsqsqlpg tansvpecis
      541 ltsledpvil skcgqldsal heatsrvrtl enknnlleie vndlrerfsa assaskilqe
      601 rieemrtssk ekdntiirlk srlqdleeaf enayklsddk eaqlkqenkm fqdllgeyes
      661 lgkehrrvkd alnttenkll daytqisdlk rmiskleaqv kqvehenmls lrhnsrihvr
      721 psrantlats dvsrrkwlip gaeysiftgq pldtqdsnvd nqleetcslg hrsplekdss
      781 pgssstslli kkqretsdtp imralkelde gkifknwgtq tekedtsnin prqtetsvna
      841 srspekcaqq rqkrlnsasq rssslppsnr ksstptkrei mltpvtvays pkrspkenls
      901 pgfshllskn esspirfdil lddldtvpvs tlqrtnprkq lqflplddse ektysekatd
      961 nhvnhsscpe pvpngvkkvs vrtaweknks vsyeqckpvs vtpqgndfey takirtlaet
     1021 erffdeltke kdqieaalsr mpspggritl qtrlnqeale drlerinrel gsvrmtlkkf
     1081 hvlrtsanl
//
LOCUS       XP_054226725            1066 aa            linear   PRI 05-AUG-2025
DEFINITION  M-phase phosphoprotein 9 isoform X13 [Homo sapiens].
ACCESSION   XP_054226725
VERSION     XP_054226725.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370750.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1066
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1066
                     /product="M-phase phosphoprotein 9 isoform X13"
                     /calculated_mol_wt=119507
     Region          <550..>756
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1066
                     /gene="MPHOSPH9"
                     /gene_synonym="MPP-9; MPP9"
                     /coded_by="XM_054370750.1:226..3426"
                     /db_xref="GeneID:10198"
                     /db_xref="HGNC:HGNC:7215"
                     /db_xref="MIM:605501"
ORIGIN      
        1 meefdlvktl hktsssvgsd enslhslgln lntdrssphl stngvssfsg ktrpsviqgt
       61 vevltslmqe lqnsgktdse lwkncetrwl qlfnlvekqc qeqivaqqeq fhnqiqhiqe
      121 eiknlvklqt ssaslasceg nssnkqvsse sqmgffslss ernesvihyp estepeiqqe
      181 mstsqpdcnv dscsvssgyg tfciselnly kskdpkefme hidvpkgqyv apavpaeslv
      241 dgvknenfyi qtpeechvsl kedvsispge fehnflgenk vsevysgktn snaitswaqk
      301 lkqnqpkrah vedggsrskq gneqskktpi eksdfaaath prafylskpd etpnawmsds
      361 gtgltywkle ekdmhhslpe tlektfisls stdvspnqvl tldptlhmkp kqqisgiqph
      421 glpnalddri sfspdsvlep smsspsdids fsqasnvtsq lpgfpkypsh tkaspvdswk
      481 nqtfqnesrt sstfpsvyti tsndisvntv deentvmvas asvsqsqlpg tansvpecis
      541 ltsledpvil skirqnlkek harhiadlra yyeseinslk qkleakeisg vedwkitnqi
      601 lvdrcgqlds alheatsrvr tlenknnlle ievndlrerf saassaskil qerieemrts
      661 skekdntiir lksrlqdlee afenayklsd dkeaqlkqen kmfqdllgey eslgkehrrv
      721 kdalnttenk lldaytqisd lkrmisklea qvkqvehenm lslrhnsrih vrpsrantla
      781 tsdvsrrkwl ipgaeysift gqpldtqdsn vdnqleetcs lghrsplekd sspgssstsl
      841 likkqretsd tpimralkel degkifknwg tqtekedtsn inprqtetsv nasrspekca
      901 qqrqkrlnsa sqrssslpps nrksstpkkt ysekatdnhv nhsscpepvp ngvkkvsvrt
      961 aweknksvsy eqckpvsvtp qgndfeytak irtlaeterf fdeltkekdq ieaalsrmps
     1021 pggritlqtr lnqealedrl erinrelgsv rmtlkkfhvl rtsanl
//
LOCUS       XP_054226726            1032 aa            linear   PRI 05-AUG-2025
DEFINITION  M-phase phosphoprotein 9 isoform X14 [Homo sapiens].
ACCESSION   XP_054226726
VERSION     XP_054226726.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370751.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1032
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1032
                     /product="M-phase phosphoprotein 9 isoform X14"
                     /calculated_mol_wt=115563
     Region          <592..>798
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1032
                     /gene="MPHOSPH9"
                     /gene_synonym="MPP-9; MPP9"
                     /coded_by="XM_054370751.1:226..3324"
                     /db_xref="GeneID:10198"
                     /db_xref="HGNC:HGNC:7215"
                     /db_xref="MIM:605501"
ORIGIN      
        1 meefdlvktl hktsssvgsd enslhslgln lntdrssphl stngvssfsg ktrpsviqgt
       61 vevltslmqe lqnsgktdse lwkncetrwl qlfnlvekqc qeqivaqqeq fhnqiqhiqe
      121 eiknlvklqt ssaslasceg nssnkqvsse sqmgffslss ernesvihyp estepeiqqe
      181 mstsqpdcnv dscsvssgyg tfciselnly kskdpkefme hidvpkgqyv apavpaeslv
      241 dgvknenfyi qtpeechvsl kedvsispge fehnflgenk vsevysgktn snaitswaqk
      301 lkqnqpkrah vedggsrskq gneqskktpi eksdfaaath prafylskpd etpnawmsds
      361 gtgltywkle ekdmhhslpe tlektfisls stdvspnqsn tsnemklpsl kdiyykkqre
      421 nkqlpernlt sasnpnhppe vltldptlhm kpkqqisgiq phglpnaldd risfspdsvl
      481 epsmsspsdi dsfsqasnvt sqlpgfpkyp shtkaspvds wknqtfqnes rtsstfpsvy
      541 titsndisvn tvdeentvmv asasvsqsql pgtansvpec isltsledpv ilskirqnlk
      601 ekharhiadl rayyeseins lkqkleakei sgvedwkitn qilvdrcgql dsalheatsr
      661 vrtlenknnl leievndlre rfsaassask ilqerieemr tsskekdnti irlksrlqdl
      721 eeafenaykl sddkeaqlkq enkmfqdllg eyeslgkehr rvkdalntte nklldaytqi
      781 sdlkrmiskl eaqvkqvehe nmlslrhnsr ihvrpsrant latsdvsrrk wlipgaeysi
      841 ftgqpldtqd snvdnqleet cslghrsple kdsspgssst sllikkqret sdtpimralk
      901 eldegkifkn wgtqtekedt sninprqtet svnasrspek caqqrqkrln sasqrssslp
      961 psnrksstpt kreimltpvt vayspkrspk enlspgfshl lsknesspir ycscvyitty
     1021 qskkatpvss sr
//
LOCUS       XP_054226727            1031 aa            linear   PRI 05-AUG-2025
DEFINITION  M-phase phosphoprotein 9 isoform X15 [Homo sapiens].
ACCESSION   XP_054226727
VERSION     XP_054226727.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370752.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1031
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1031
                     /product="M-phase phosphoprotein 9 isoform X15"
                     /calculated_mol_wt=116004
     Region          <440..>646
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1031
                     /gene="MPHOSPH9"
                     /gene_synonym="MPP-9; MPP9"
                     /coded_by="XM_054370752.1:458..3553"
                     /db_xref="GeneID:10198"
                     /db_xref="HGNC:HGNC:7215"
                     /db_xref="MIM:605501"
ORIGIN      
        1 mgffslsser nesvihypes tepeiqqems tsqpdcnvds csvssgygtf ciselnlyks
       61 kdpkefmehi dvpkgqyvap avpaeslvdg vknenfyiqt peechvslke dvsispgefe
      121 hnflgenkvs evysgktnsn aitswaqklk qnqpkrahve dggsrskqgn eqskktpiek
      181 sdfaaathpr afylskpdet pnawmsdsgt gltywkleek dmhhslpetl ektfislsst
      241 dvspnqsnts nemklpslkd iyykkqrenk qlpernltsa snpnhppevl tldptlhmkp
      301 kqqisgiqph glpnalddri sfspdsvlep smsspsdids fsqasnvtsq lpgfpkypsh
      361 tkaspvdswk nqtfqnesrt sstfpsvyti tsndisvntv deentvmvas asvsqsqlpg
      421 tansvpecis ltsledpvil skirqnlkek harhiadlra yyeseinslk qkleakeisg
      481 vedwkitnqi lvdrcgqlds alheatsrvr tlenknnlle ievndlrerf saassaskil
      541 qerieemrts skekdntiir lksrlqdlee afenayklsd dkeaqlkqen kmfqdllgey
      601 eslgkehrrv kdalnttenk lldaytqisd lkrmisklea qvkqvehenm lslrhnsrih
      661 vrpsrantla tsdvsrrkwl ipgaeysift gqpldtqdsn vdnqleetcs lghrsplekd
      721 sspgssstsl likkqretsd tpimralkel degkifknwg tqtekedtsn inprqtetsv
      781 nasrspekca qqrqkrlnsa sqrssslpps nrksstptkr eimltpvtva yspkrspken
      841 lspgfshlls knesspirfd illddldtvp vstlqrtnpr kqlqflpldd seektyseka
      901 tdnhvnhssc pepvpngvkk vsvrtawekn ksvsyeqckp vsvtpqgndf eytakirtla
      961 eterffdelt kekdqieaal srmpspggri tlqtrlnqea ledrlerinr elgsvrmtlk
     1021 kfhvlrtsan l
//
LOCUS       XP_054226728            1031 aa            linear   PRI 05-AUG-2025
DEFINITION  M-phase phosphoprotein 9 isoform X15 [Homo sapiens].
ACCESSION   XP_054226728
VERSION     XP_054226728.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370753.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1031
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1031
                     /product="M-phase phosphoprotein 9 isoform X15"
                     /calculated_mol_wt=116004
     Region          <440..>646
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1031
                     /gene="MPHOSPH9"
                     /gene_synonym="MPP-9; MPP9"
                     /coded_by="XM_054370753.1:308..3403"
                     /db_xref="GeneID:10198"
                     /db_xref="HGNC:HGNC:7215"
                     /db_xref="MIM:605501"
ORIGIN      
        1 mgffslsser nesvihypes tepeiqqems tsqpdcnvds csvssgygtf ciselnlyks
       61 kdpkefmehi dvpkgqyvap avpaeslvdg vknenfyiqt peechvslke dvsispgefe
      121 hnflgenkvs evysgktnsn aitswaqklk qnqpkrahve dggsrskqgn eqskktpiek
      181 sdfaaathpr afylskpdet pnawmsdsgt gltywkleek dmhhslpetl ektfislsst
      241 dvspnqsnts nemklpslkd iyykkqrenk qlpernltsa snpnhppevl tldptlhmkp
      301 kqqisgiqph glpnalddri sfspdsvlep smsspsdids fsqasnvtsq lpgfpkypsh
      361 tkaspvdswk nqtfqnesrt sstfpsvyti tsndisvntv deentvmvas asvsqsqlpg
      421 tansvpecis ltsledpvil skirqnlkek harhiadlra yyeseinslk qkleakeisg
      481 vedwkitnqi lvdrcgqlds alheatsrvr tlenknnlle ievndlrerf saassaskil
      541 qerieemrts skekdntiir lksrlqdlee afenayklsd dkeaqlkqen kmfqdllgey
      601 eslgkehrrv kdalnttenk lldaytqisd lkrmisklea qvkqvehenm lslrhnsrih
      661 vrpsrantla tsdvsrrkwl ipgaeysift gqpldtqdsn vdnqleetcs lghrsplekd
      721 sspgssstsl likkqretsd tpimralkel degkifknwg tqtekedtsn inprqtetsv
      781 nasrspekca qqrqkrlnsa sqrssslpps nrksstptkr eimltpvtva yspkrspken
      841 lspgfshlls knesspirfd illddldtvp vstlqrtnpr kqlqflpldd seektyseka
      901 tdnhvnhssc pepvpngvkk vsvrtawekn ksvsyeqckp vsvtpqgndf eytakirtla
      961 eterffdelt kekdqieaal srmpspggri tlqtrlnqea ledrlerinr elgsvrmtlk
     1021 kfhvlrtsan l
//
LOCUS       XP_054226729            1014 aa            linear   PRI 05-AUG-2025
DEFINITION  M-phase phosphoprotein 9 isoform X16 [Homo sapiens].
ACCESSION   XP_054226729
VERSION     XP_054226729.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370754.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1014
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1014
                     /product="M-phase phosphoprotein 9 isoform X16"
                     /calculated_mol_wt=113611
     Region          <592..>798
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..1014
                     /gene="MPHOSPH9"
                     /gene_synonym="MPP-9; MPP9"
                     /coded_by="XM_054370754.1:226..3270"
                     /db_xref="GeneID:10198"
                     /db_xref="HGNC:HGNC:7215"
                     /db_xref="MIM:605501"
ORIGIN      
        1 meefdlvktl hktsssvgsd enslhslgln lntdrssphl stngvssfsg ktrpsviqgt
       61 vevltslmqe lqnsgktdse lwkncetrwl qlfnlvekqc qeqivaqqeq fhnqiqhiqe
      121 eiknlvklqt ssaslasceg nssnkqvsse sqmgffslss ernesvihyp estepeiqqe
      181 mstsqpdcnv dscsvssgyg tfciselnly kskdpkefme hidvpkgqyv apavpaeslv
      241 dgvknenfyi qtpeechvsl kedvsispge fehnflgenk vsevysgktn snaitswaqk
      301 lkqnqpkrah vedggsrskq gneqskktpi eksdfaaath prafylskpd etpnawmsds
      361 gtgltywkle ekdmhhslpe tlektfisls stdvspnqsn tsnemklpsl kdiyykkqre
      421 nkqlpernlt sasnpnhppe vltldptlhm kpkqqisgiq phglpnaldd risfspdsvl
      481 epsmsspsdi dsfsqasnvt sqlpgfpkyp shtkaspvds wknqtfqnes rtsstfpsvy
      541 titsndisvn tvdeentvmv asasvsqsql pgtansvpec isltsledpv ilskirqnlk
      601 ekharhiadl rayyeseins lkqkleakei sgvedwkitn qilvdrcgql dsalheatsr
      661 vrtlenknnl leievndlre rfsaassask ilqerieemr tsskekdnti irlksrlqdl
      721 eeafenaykl sddkeaqlkq enkmfqdllg eyeslgkehr rvkdalntte nklldaytqi
      781 sdlkrmiskl eaqvkqvehe nmlslrhnsr ihvrpsrant latsdvsrrk wlipgaeysi
      841 ftgqpldtqd snvdnqleet cslghrsple kdsspgssst sllikkqret sdtpimralk
      901 eldegkifkn wgtqtekedt sninprqtet svnasrspek caqqrqkrln sasqrssslp
      961 psnrksstpt kreimltpvt vayspkrspk enlspgfshl lsknesspir knlf
//
LOCUS       XP_054226730             925 aa            linear   PRI 05-AUG-2025
DEFINITION  M-phase phosphoprotein 9 isoform X17 [Homo sapiens].
ACCESSION   XP_054226730
VERSION     XP_054226730.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370755.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..925
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..925
                     /product="M-phase phosphoprotein 9 isoform X17"
                     /calculated_mol_wt=103664
     Region          <592..>798
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..925
                     /gene="MPHOSPH9"
                     /gene_synonym="MPP-9; MPP9"
                     /coded_by="XM_054370755.1:226..3003"
                     /db_xref="GeneID:10198"
                     /db_xref="HGNC:HGNC:7215"
                     /db_xref="MIM:605501"
ORIGIN      
        1 meefdlvktl hktsssvgsd enslhslgln lntdrssphl stngvssfsg ktrpsviqgt
       61 vevltslmqe lqnsgktdse lwkncetrwl qlfnlvekqc qeqivaqqeq fhnqiqhiqe
      121 eiknlvklqt ssaslasceg nssnkqvsse sqmgffslss ernesvihyp estepeiqqe
      181 mstsqpdcnv dscsvssgyg tfciselnly kskdpkefme hidvpkgqyv apavpaeslv
      241 dgvknenfyi qtpeechvsl kedvsispge fehnflgenk vsevysgktn snaitswaqk
      301 lkqnqpkrah vedggsrskq gneqskktpi eksdfaaath prafylskpd etpnawmsds
      361 gtgltywkle ekdmhhslpe tlektfisls stdvspnqsn tsnemklpsl kdiyykkqre
      421 nkqlpernlt sasnpnhppe vltldptlhm kpkqqisgiq phglpnaldd risfspdsvl
      481 epsmsspsdi dsfsqasnvt sqlpgfpkyp shtkaspvds wknqtfqnes rtsstfpsvy
      541 titsndisvn tvdeentvmv asasvsqsql pgtansvpec isltsledpv ilskirqnlk
      601 ekharhiadl rayyeseins lkqkleakei sgvedwkitn qilvdrcgql dsalheatsr
      661 vrtlenknnl leievndlre rfsaassask ilqerieemr tsskekdnti irlksrlqdl
      721 eeafenaykl sddkeaqlkq enkmfqdllg eyeslgkehr rvkdalntte nklldaytqi
      781 sdlkrmiskl eaqvkqvehe nmlslrhnsr ihvrpsrant latsdvsrrk wlipgaeysi
      841 ftgqpldtqd snvdnqleet cslghrsple kdsspgssst sllikkqret sdtpimralk
      901 eldegkifkn wgtqtekedt snsll
//
LOCUS       XP_054226731             810 aa            linear   PRI 05-AUG-2025
DEFINITION  M-phase phosphoprotein 9 isoform X18 [Homo sapiens].
ACCESSION   XP_054226731
VERSION     XP_054226731.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370756.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..810
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..810
                     /product="M-phase phosphoprotein 9 isoform X18"
                     /calculated_mol_wt=91349
     Region          <219..>425
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     CDS             1..810
                     /gene="MPHOSPH9"
                     /gene_synonym="MPP-9; MPP9"
                     /coded_by="XM_054370756.1:121..2553"
                     /db_xref="GeneID:10198"
                     /db_xref="HGNC:HGNC:7215"
                     /db_xref="MIM:605501"
ORIGIN      
        1 mhhslpetle ktfislsstd vspnqsntsn emklpslkdi yykkqrenkq lpernltsas
       61 npnhppevlt ldptlhmkpk qqisgiqphg lpnalddris fspdsvleps msspsdidsf
      121 sqasnvtsql pgfpkypsht kaspvdswkn qtfqnesrts stfpsvytit sndisvntvd
      181 eentvmvasa svsqsqlpgt ansvpecisl tsledpvils kirqnlkekh arhiadlray
      241 yeseinslkq kleakeisgv edwkitnqil vdrcgqldsa lheatsrvrt lenknnllei
      301 evndlrerfs aassaskilq erieemrtss kekdntiirl ksrlqdleea fenayklsdd
      361 keaqlkqenk mfqdllgeye slgkehrrvk dalnttenkl ldaytqisdl krmiskleaq
      421 vkqvehenml slrhnsrihv rpsrantlat sdvsrrkwli pgaeysiftg qpldtqdsnv
      481 dnqleetcsl ghrsplekds spgssstsll ikkqretsdt pimralkeld egkifknwgt
      541 qtekedtsni nprqtetsvn asrspekcaq qrqkrlnsas qrssslppsn rksstptkre
      601 imltpvtvay spkrspkenl spgfshllsk nesspirfdi llddldtvpv stlqrtnprk
      661 qlqflpldds eektysekat dnhvnhsscp epvpngvkkv svrtaweknk svsyeqckpv
      721 svtpqgndfe ytakirtlae terffdeltk ekdqieaals rmpspggrit lqtrlnqeal
      781 edrlerinre lgsvrmtlkk fhvlrtsanl
//
LOCUS       XP_054226732             199 aa            linear   PRI 05-AUG-2025
DEFINITION  killer cell lectin-like receptor subfamily G member 1 isoform X1
            [Homo sapiens].
ACCESSION   XP_054226732
VERSION     XP_054226732.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370757.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..199
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..199
                     /product="killer cell lectin-like receptor subfamily G
                     member 1 isoform X1"
                     /calculated_mol_wt=22157
     Region          75..186
                     /region_name="CLECT_NK_receptors_like"
                     /note="C-type lectin-like domain (CTLD) of the type found
                     in natural killer cell receptors (NKRs); cd03593"
                     /db_xref="CDD:153063"
     Site            order(130,154,170,172..173)
                     /site_type="other"
                     /note="ligand binding surface [chemical binding]"
                     /db_xref="CDD:153063"
     CDS             1..199
                     /gene="KLRG1"
                     /gene_synonym="2F1; CLEC15A; MAFA; MAFA-2F1; MAFA-L;
                     MAFA-LIKE"
                     /coded_by="XM_054370757.1:91..690"
                     /db_xref="GeneID:10219"
                     /db_xref="HGNC:HGNC:6380"
                     /db_xref="MIM:604874"
ORIGIN      
        1 mtdsviysml elptatqaqn dygpqqksss srpscsclva ialglltavl lsvllyqwil
       61 cqgsnystca scpscpdrwm kygnhcyyfs veekdwnssl efclardshl lvitdnqems
      121 llqvflseaf cwiglrnnsg wrwedgspln fsrissnsfv qtcgainkng lqasscevpl
      181 hwvckketgv hqglffcck
//
LOCUS       XP_054226733             199 aa            linear   PRI 05-AUG-2025
DEFINITION  killer cell lectin-like receptor subfamily G member 1 isoform X1
            [Homo sapiens].
ACCESSION   XP_054226733
VERSION     XP_054226733.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370758.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..199
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..199
                     /product="killer cell lectin-like receptor subfamily G
                     member 1 isoform X1"
                     /calculated_mol_wt=22157
     Region          75..186
                     /region_name="CLECT_NK_receptors_like"
                     /note="C-type lectin-like domain (CTLD) of the type found
                     in natural killer cell receptors (NKRs); cd03593"
                     /db_xref="CDD:153063"
     Site            order(130,154,170,172..173)
                     /site_type="other"
                     /note="ligand binding surface [chemical binding]"
                     /db_xref="CDD:153063"
     CDS             1..199
                     /gene="KLRG1"
                     /gene_synonym="2F1; CLEC15A; MAFA; MAFA-2F1; MAFA-L;
                     MAFA-LIKE"
                     /coded_by="XM_054370758.1:91..690"
                     /db_xref="GeneID:10219"
                     /db_xref="HGNC:HGNC:6380"
                     /db_xref="MIM:604874"
ORIGIN      
        1 mtdsviysml elptatqaqn dygpqqksss srpscsclva ialglltavl lsvllyqwil
       61 cqgsnystca scpscpdrwm kygnhcyyfs veekdwnssl efclardshl lvitdnqems
      121 llqvflseaf cwiglrnnsg wrwedgspln fsrissnsfv qtcgainkng lqasscevpl
      181 hwvckketgv hqglffcck
//
LOCUS       XP_054226734             199 aa            linear   PRI 05-AUG-2025
DEFINITION  killer cell lectin-like receptor subfamily G member 1 isoform X1
            [Homo sapiens].
ACCESSION   XP_054226734
VERSION     XP_054226734.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370759.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..199
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..199
                     /product="killer cell lectin-like receptor subfamily G
                     member 1 isoform X1"
                     /calculated_mol_wt=22157
     Region          75..186
                     /region_name="CLECT_NK_receptors_like"
                     /note="C-type lectin-like domain (CTLD) of the type found
                     in natural killer cell receptors (NKRs); cd03593"
                     /db_xref="CDD:153063"
     Site            order(130,154,170,172..173)
                     /site_type="other"
                     /note="ligand binding surface [chemical binding]"
                     /db_xref="CDD:153063"
     CDS             1..199
                     /gene="KLRG1"
                     /gene_synonym="2F1; CLEC15A; MAFA; MAFA-2F1; MAFA-L;
                     MAFA-LIKE"
                     /coded_by="XM_054370759.1:91..690"
                     /db_xref="GeneID:10219"
                     /db_xref="HGNC:HGNC:6380"
                     /db_xref="MIM:604874"
ORIGIN      
        1 mtdsviysml elptatqaqn dygpqqksss srpscsclva ialglltavl lsvllyqwil
       61 cqgsnystca scpscpdrwm kygnhcyyfs veekdwnssl efclardshl lvitdnqems
      121 llqvflseaf cwiglrnnsg wrwedgspln fsrissnsfv qtcgainkng lqasscevpl
      181 hwvckketgv hqglffcck
//
LOCUS       XP_054226735             199 aa            linear   PRI 05-AUG-2025
DEFINITION  killer cell lectin-like receptor subfamily G member 1 isoform X1
            [Homo sapiens].
ACCESSION   XP_054226735
VERSION     XP_054226735.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370760.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..199
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..199
                     /product="killer cell lectin-like receptor subfamily G
                     member 1 isoform X1"
                     /calculated_mol_wt=22157
     Region          75..186
                     /region_name="CLECT_NK_receptors_like"
                     /note="C-type lectin-like domain (CTLD) of the type found
                     in natural killer cell receptors (NKRs); cd03593"
                     /db_xref="CDD:153063"
     Site            order(130,154,170,172..173)
                     /site_type="other"
                     /note="ligand binding surface [chemical binding]"
                     /db_xref="CDD:153063"
     CDS             1..199
                     /gene="KLRG1"
                     /gene_synonym="2F1; CLEC15A; MAFA; MAFA-2F1; MAFA-L;
                     MAFA-LIKE"
                     /coded_by="XM_054370760.1:91..690"
                     /db_xref="GeneID:10219"
                     /db_xref="HGNC:HGNC:6380"
                     /db_xref="MIM:604874"
ORIGIN      
        1 mtdsviysml elptatqaqn dygpqqksss srpscsclva ialglltavl lsvllyqwil
       61 cqgsnystca scpscpdrwm kygnhcyyfs veekdwnssl efclardshl lvitdnqems
      121 llqvflseaf cwiglrnnsg wrwedgspln fsrissnsfv qtcgainkng lqasscevpl
      181 hwvckketgv hqglffcck
//
LOCUS       XP_054226736             199 aa            linear   PRI 05-AUG-2025
DEFINITION  killer cell lectin-like receptor subfamily G member 1 isoform X1
            [Homo sapiens].
ACCESSION   XP_054226736
VERSION     XP_054226736.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370761.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..199
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..199
                     /product="killer cell lectin-like receptor subfamily G
                     member 1 isoform X1"
                     /calculated_mol_wt=22157
     Region          75..186
                     /region_name="CLECT_NK_receptors_like"
                     /note="C-type lectin-like domain (CTLD) of the type found
                     in natural killer cell receptors (NKRs); cd03593"
                     /db_xref="CDD:153063"
     Site            order(130,154,170,172..173)
                     /site_type="other"
                     /note="ligand binding surface [chemical binding]"
                     /db_xref="CDD:153063"
     CDS             1..199
                     /gene="KLRG1"
                     /gene_synonym="2F1; CLEC15A; MAFA; MAFA-2F1; MAFA-L;
                     MAFA-LIKE"
                     /coded_by="XM_054370761.1:91..690"
                     /db_xref="GeneID:10219"
                     /db_xref="HGNC:HGNC:6380"
                     /db_xref="MIM:604874"
ORIGIN      
        1 mtdsviysml elptatqaqn dygpqqksss srpscsclva ialglltavl lsvllyqwil
       61 cqgsnystca scpscpdrwm kygnhcyyfs veekdwnssl efclardshl lvitdnqems
      121 llqvflseaf cwiglrnnsg wrwedgspln fsrissnsfv qtcgainkng lqasscevpl
      181 hwvckketgv hqglffcck
//
LOCUS       XP_054226737             175 aa            linear   PRI 05-AUG-2025
DEFINITION  killer cell lectin-like receptor subfamily G member 1 isoform X3
            [Homo sapiens].
ACCESSION   XP_054226737
VERSION     XP_054226737.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370762.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..175
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..175
                     /product="killer cell lectin-like receptor subfamily G
                     member 1 isoform X3"
                     /calculated_mol_wt=19605
     Region          61..172
                     /region_name="CLECT_NK_receptors_like"
                     /note="C-type lectin-like domain (CTLD) of the type found
                     in natural killer cell receptors (NKRs); cd03593"
                     /db_xref="CDD:153063"
     Site            order(116,140,156,158..159)
                     /site_type="other"
                     /note="ligand binding surface [chemical binding]"
                     /db_xref="CDD:153063"
     CDS             1..175
                     /gene="KLRG1"
                     /gene_synonym="2F1; CLEC15A; MAFA; MAFA-2F1; MAFA-L;
                     MAFA-LIKE"
                     /coded_by="XM_054370762.1:586..1113"
                     /db_xref="GeneID:10219"
                     /db_xref="HGNC:HGNC:6380"
                     /db_xref="MIM:604874"
ORIGIN      
        1 mllkspehev ffvasssrps csclvaialg lltavllsvl lyqwilcqgs nystcascps
       61 cpdrwmkygn hcyyfsveek dwnsslefcl ardshllvit dnqemsllqv flseafcwig
      121 lrnnsgwrwe dgsplnfsri ssnsfvqtcg ainknglqas scevplhwvc kkvrl
//
LOCUS       XP_054226738             172 aa            linear   PRI 05-AUG-2025
DEFINITION  killer cell lectin-like receptor subfamily G member 1 isoform X2
            [Homo sapiens].
ACCESSION   XP_054226738
VERSION     XP_054226738.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370763.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..172
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..172
                     /product="killer cell lectin-like receptor subfamily G
                     member 1 isoform X2"
                     /calculated_mol_wt=19152
     Region          58..169
                     /region_name="CLECT_NK_receptors_like"
                     /note="C-type lectin-like domain (CTLD) of the type found
                     in natural killer cell receptors (NKRs); cd03593"
                     /db_xref="CDD:153063"
     Site            order(113,137,153,155..156)
                     /site_type="other"
                     /note="ligand binding surface [chemical binding]"
                     /db_xref="CDD:153063"
     CDS             1..172
                     /gene="KLRG1"
                     /gene_synonym="2F1; CLEC15A; MAFA; MAFA-2F1; MAFA-L;
                     MAFA-LIKE"
                     /coded_by="XM_054370763.1:303..821"
                     /db_xref="GeneID:10219"
                     /db_xref="HGNC:HGNC:6380"
                     /db_xref="MIM:604874"
ORIGIN      
        1 meqlsaergc asssrpscsc lvaialgllt avllsvllyq wilcqgsnys tcascpscpd
       61 rwmkygnhcy yfsveekdwn sslefclard shllvitdnq emsllqvfls eafcwiglrn
      121 nsgwrwedgs plnfsrissn sfvqtcgain knglqassce vplhwvckkv rl
//
LOCUS       XP_054226742             938 aa            linear   PRI 05-AUG-2025
DEFINITION  rap guanine nucleotide exchange factor 3 isoform X1 [Homo sapiens].
ACCESSION   XP_054226742
VERSION     XP_054226742.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370767.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..938
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..938
                     /product="rap guanine nucleotide exchange factor 3 isoform
                     X1"
                     /calculated_mol_wt=105051
     Region          100..238
                     /region_name="DEP_Epac"
                     /note="DEP (Dishevelled, Egl-10, and Pleckstrin) domain
                     found in Epac-like proteins. Epac (exchange proteins
                     directly activated by cAMP) proteins are GEFs
                     (guanine-nucleotide-exchange factors) for the small
                     GTPases, Rap1 and Rap2. They are directly regulated by...;
                     cd04437"
                     /db_xref="CDD:239884"
     Region          262..371
                     /region_name="CAP_ED"
                     /note="effector domain of the CAP family of transcription
                     factors; members include CAP (or cAMP receptor protein
                     (CRP)), which binds cAMP, FNR (fumarate and nitrate
                     reduction), which uses an iron-sulfur cluster to sense
                     oxygen) and CooA, a heme containing CO...; cd00038"
                     /db_xref="CDD:237999"
     Site            order(326..327,336..338)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:237999"
     Site            order(359..361,365..367)
                     /site_type="other"
                     /note="flexible hinge region"
                     /db_xref="CDD:237999"
     Region          407..526
                     /region_name="REM"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     GTPases; N-terminal domain (RasGef_N), also called REM
                     domain (Ras exchanger motif). This domain is common in
                     nucleotide exchange factors for Ras-like small GTPases and
                     is typically found immediately...; cd06224"
                     /db_xref="CDD:100121"
     Site            order(418,474,478..479,482,485..486,521..522,525)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:100121"
     Region          673..905
                     /region_name="RasGEF"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     small GTPases. Small GTP-binding proteins of the Ras
                     superfamily function as molecular switches in fundamental
                     events such as signal transduction, cytoskeleton dynamics
                     and intracellular trafficking; cd00155"
                     /db_xref="CDD:238087"
     Site            order(706..708,719..720,722..724,726..727,730..731,734,
                     767,770..771,773..775,777..780,782..783,803,806,811..813,
                     816,829..831,834..836,838..840,842..845,859,863,898,
                     901..902)
                     /site_type="other"
                     /note="Ras interaction site [polypeptide binding]"
                     /db_xref="CDD:238087"
     CDS             1..938
                     /gene="RAPGEF3"
                     /gene_synonym="bcm910; CAMP-GEFI; EPAC; EPAC1; HSU79275"
                     /coded_by="XM_054370767.1:325..3141"
                     /db_xref="GeneID:10411"
                     /db_xref="HGNC:HGNC:16629"
                     /db_xref="MIM:606057"
ORIGIN      
        1 mkvgwpgesc wqvglpveds palgaprvga lpdvvpegtl lnmvlrrmhr prscsyqlll
       61 ehqrpsciqg lrwtpltnse esldfsesle qastervlra grqlhrhlla tcpnlirdrk
      121 yhlrlyrqcc sgrelvdgil alglgvhsrs qvvgicqvll degalchasi ssppprlglc
      181 ppvkhdwafq drdaqfyrfp gpepepvgth emeeelaeav allsqrgpda lltvalrkpp
      241 gqrtdeeldl ifeellhika vahlsnsvkr elaavllfep hskagtvlfs qgdkgtswyi
      301 iwkgsvnvvt hgkglvttlh egddfgqlal vndapraati ilrednchfl rvdkqdfnri
      361 ikdveaktmr leehgkvvlv lerasqgasp srpptpgrnr ytvmsgtpek ilellleamg
      421 pdssahdpte tflsdfllth rvfmpsaqlc aallhhfhve paggseqers tyvcnkrqqi
      481 lrlvsqwval ygsmlhtdpv atsflqklsd lvgrdtrlsn llreqwperr rchrlengcg
      541 naspqmkarn lpvwlpnqde plpgsscaiq vgdkvpydic rpdhsvltlq lpvtasvrev
      601 maalaqedgw tkgqvlvkvn sagdaiglqp dargvatslg lnerlfvvnp qevheliphp
      661 dqlgptvgsa egldlvsakd lagqltdhdw slfnsihqve lihyvlgpqh lrdvttanle
      721 rfmrrfnelq ywvatelclc pvpgpraqll rkfiklaahl keqknlnsff avmfglsnsa
      781 isrlahtwer lphkvrklys alerlldpsw nhrvyrlala klsppvipfm plllkdmtfi
      841 hegnhtlven linfekmrmm araarmlhhc rshnpvplsp lrsrvshlhe dsqvaristc
      901 seqslstrsp astwayvqql kvidnqrels rlsrelep
//
LOCUS       XP_054226743             896 aa            linear   PRI 05-AUG-2025
DEFINITION  rap guanine nucleotide exchange factor 3 isoform X2 [Homo sapiens].
ACCESSION   XP_054226743
VERSION     XP_054226743.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370768.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..896
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..896
                     /product="rap guanine nucleotide exchange factor 3 isoform
                     X2"
                     /calculated_mol_wt=100726
     Region          58..196
                     /region_name="DEP_Epac"
                     /note="DEP (Dishevelled, Egl-10, and Pleckstrin) domain
                     found in Epac-like proteins. Epac (exchange proteins
                     directly activated by cAMP) proteins are GEFs
                     (guanine-nucleotide-exchange factors) for the small
                     GTPases, Rap1 and Rap2. They are directly regulated by...;
                     cd04437"
                     /db_xref="CDD:239884"
     Region          220..329
                     /region_name="CAP_ED"
                     /note="effector domain of the CAP family of transcription
                     factors; members include CAP (or cAMP receptor protein
                     (CRP)), which binds cAMP, FNR (fumarate and nitrate
                     reduction), which uses an iron-sulfur cluster to sense
                     oxygen) and CooA, a heme containing CO...; cd00038"
                     /db_xref="CDD:237999"
     Site            order(284..285,294..296)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:237999"
     Site            order(317..319,323..325)
                     /site_type="other"
                     /note="flexible hinge region"
                     /db_xref="CDD:237999"
     Region          365..484
                     /region_name="REM"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     GTPases; N-terminal domain (RasGef_N), also called REM
                     domain (Ras exchanger motif). This domain is common in
                     nucleotide exchange factors for Ras-like small GTPases and
                     is typically found immediately...; cd06224"
                     /db_xref="CDD:100121"
     Site            order(376,432,436..437,440,443..444,479..480,483)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:100121"
     Region          631..863
                     /region_name="RasGEF"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     small GTPases. Small GTP-binding proteins of the Ras
                     superfamily function as molecular switches in fundamental
                     events such as signal transduction, cytoskeleton dynamics
                     and intracellular trafficking; cd00155"
                     /db_xref="CDD:238087"
     Site            order(664..666,677..678,680..682,684..685,688..689,692,
                     725,728..729,731..733,735..738,740..741,761,764,769..771,
                     774,787..789,792..794,796..798,800..803,817,821,856,
                     859..860)
                     /site_type="other"
                     /note="Ras interaction site [polypeptide binding]"
                     /db_xref="CDD:238087"
     CDS             1..896
                     /gene="RAPGEF3"
                     /gene_synonym="bcm910; CAMP-GEFI; EPAC; EPAC1; HSU79275"
                     /coded_by="XM_054370768.1:211..2901"
                     /db_xref="GeneID:10411"
                     /db_xref="HGNC:HGNC:16629"
                     /db_xref="MIM:606057"
ORIGIN      
        1 mvlrrmhrpr scsyqllleh qrpsciqglr wtpltnsees ldfsesleqa stervlragr
       61 qlhrhllatc pnlirdrkyh lrlyrqccsg relvdgilal glgvhsrsqv vgicqvllde
      121 galchasiss ppprlglcpp vkhdwafqdr daqfyrfpgp epepvgthem eeelaeaval
      181 lsqrgpdall tvalrkppgq rtdeeldlif eellhikava hlsnsvkrel aavllfephs
      241 kagtvlfsqg dkgtswyiiw kgsvnvvthg kglvttlheg ddfgqlalvn dapraatiil
      301 rednchflrv dkqdfnriik dveaktmrle ehgkvvlvle rasqgaspsr pptpgrnryt
      361 vmsgtpekil ellleamgpd ssahdptetf lsdfllthrv fmpsaqlcaa llhhfhvepa
      421 ggseqersty vcnkrqqilr lvsqwvalyg smlhtdpvat sflqklsdlv grdtrlsnll
      481 reqwperrrc hrlengcgna spqmkarnlp vwlpnqdepl pgsscaiqvg dkvpydicrp
      541 dhsvltlqlp vtasvrevma alaqedgwtk gqvlvkvnsa gdaiglqpda rgvatslgln
      601 erlfvvnpqe vheliphpdq lgptvgsaeg ldlvsakdla gqltdhdwsl fnsihqveli
      661 hyvlgpqhlr dvttanlerf mrrfnelqyw vatelclcpv pgpraqllrk fiklaahlke
      721 qknlnsffav mfglsnsais rlahtwerlp hkvrklysal erlldpswnh rvyrlalakl
      781 sppvipfmpl llkdmtfihe gnhtlvenli nfekmrmmar aarmlhhcrs hnpvplsplr
      841 srvshlheds qvaristcse qslstrspas twayvqqlkv idnqrelsrl srelep
//
LOCUS       XP_054226744             807 aa            linear   PRI 05-AUG-2025
DEFINITION  rap guanine nucleotide exchange factor 3 isoform X3 [Homo sapiens].
ACCESSION   XP_054226744
VERSION     XP_054226744.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370769.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..807
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..807
                     /product="rap guanine nucleotide exchange factor 3 isoform
                     X3"
                     /calculated_mol_wt=89870
     Region          100..238
                     /region_name="DEP_Epac"
                     /note="DEP (Dishevelled, Egl-10, and Pleckstrin) domain
                     found in Epac-like proteins. Epac (exchange proteins
                     directly activated by cAMP) proteins are GEFs
                     (guanine-nucleotide-exchange factors) for the small
                     GTPases, Rap1 and Rap2. They are directly regulated by...;
                     cd04437"
                     /db_xref="CDD:239884"
     Region          262..371
                     /region_name="CAP_ED"
                     /note="effector domain of the CAP family of transcription
                     factors; members include CAP (or cAMP receptor protein
                     (CRP)), which binds cAMP, FNR (fumarate and nitrate
                     reduction), which uses an iron-sulfur cluster to sense
                     oxygen) and CooA, a heme containing CO...; cd00038"
                     /db_xref="CDD:237999"
     Site            order(326..327,336..338)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:237999"
     Site            order(359..361,365..367)
                     /site_type="other"
                     /note="flexible hinge region"
                     /db_xref="CDD:237999"
     Region          407..526
                     /region_name="REM"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     GTPases; N-terminal domain (RasGef_N), also called REM
                     domain (Ras exchanger motif). This domain is common in
                     nucleotide exchange factors for Ras-like small GTPases and
                     is typically found immediately...; cd06224"
                     /db_xref="CDD:100121"
     Site            order(418,474,478..479,482,485..486,521..522,525)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:100121"
     Region          673..>806
                     /region_name="RasGEF"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     small GTPases; smart00147"
                     /db_xref="CDD:214539"
     CDS             1..807
                     /gene="RAPGEF3"
                     /gene_synonym="bcm910; CAMP-GEFI; EPAC; EPAC1; HSU79275"
                     /coded_by="XM_054370769.1:325..2748"
                     /db_xref="GeneID:10411"
                     /db_xref="HGNC:HGNC:16629"
                     /db_xref="MIM:606057"
ORIGIN      
        1 mkvgwpgesc wqvglpveds palgaprvga lpdvvpegtl lnmvlrrmhr prscsyqlll
       61 ehqrpsciqg lrwtpltnse esldfsesle qastervlra grqlhrhlla tcpnlirdrk
      121 yhlrlyrqcc sgrelvdgil alglgvhsrs qvvgicqvll degalchasi ssppprlglc
      181 ppvkhdwafq drdaqfyrfp gpepepvgth emeeelaeav allsqrgpda lltvalrkpp
      241 gqrtdeeldl ifeellhika vahlsnsvkr elaavllfep hskagtvlfs qgdkgtswyi
      301 iwkgsvnvvt hgkglvttlh egddfgqlal vndapraati ilrednchfl rvdkqdfnri
      361 ikdveaktmr leehgkvvlv lerasqgasp srpptpgrnr ytvmsgtpek ilellleamg
      421 pdssahdpte tflsdfllth rvfmpsaqlc aallhhfhve paggseqers tyvcnkrqqi
      481 lrlvsqwval ygsmlhtdpv atsflqklsd lvgrdtrlsn llreqwperr rchrlengcg
      541 naspqmkarn lpvwlpnqde plpgsscaiq vgdkvpydic rpdhsvltlq lpvtasvrev
      601 maalaqedgw tkgqvlvkvn sagdaiglqp dargvatslg lnerlfvvnp qevheliphp
      661 dqlgptvgsa egldlvsakd lagqltdhdw slfnsihqve lihyvlgpqh lrdvttanle
      721 rfmrrfnelq ywvatelclc pvpgpraqll rkfiklaahl keqknlnsff avmfglsnsa
      781 isrlahtwer lphkvrklys alerllc
//
LOCUS       XP_054226745             779 aa            linear   PRI 05-AUG-2025
DEFINITION  rap guanine nucleotide exchange factor 3 isoform X4 [Homo sapiens].
ACCESSION   XP_054226745
VERSION     XP_054226745.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370770.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..779
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..779
                     /product="rap guanine nucleotide exchange factor 3 isoform
                     X4"
                     /calculated_mol_wt=87365
     Region          <32..79
                     /region_name="DEP"
                     /note="DEP domain, named after Dishevelled, Egl-10, and
                     Pleckstrin, where this domain was first discovered. The
                     function of this domain is still not clear, but it is
                     believed to be important for the membrane association of
                     the signaling proteins in which it is...; cl02442"
                     /db_xref="CDD:470580"
     Region          103..212
                     /region_name="CAP_ED"
                     /note="effector domain of the CAP family of transcription
                     factors; members include CAP (or cAMP receptor protein
                     (CRP)), which binds cAMP, FNR (fumarate and nitrate
                     reduction), which uses an iron-sulfur cluster to sense
                     oxygen) and CooA, a heme containing CO...; cd00038"
                     /db_xref="CDD:237999"
     Site            order(167..168,177..179)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:237999"
     Site            order(200..202,206..208)
                     /site_type="other"
                     /note="flexible hinge region"
                     /db_xref="CDD:237999"
     Region          248..367
                     /region_name="REM"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     GTPases; N-terminal domain (RasGef_N), also called REM
                     domain (Ras exchanger motif). This domain is common in
                     nucleotide exchange factors for Ras-like small GTPases and
                     is typically found immediately...; cd06224"
                     /db_xref="CDD:100121"
     Site            order(259,315,319..320,323,326..327,362..363,366)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:100121"
     Region          514..746
                     /region_name="RasGEF"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     small GTPases. Small GTP-binding proteins of the Ras
                     superfamily function as molecular switches in fundamental
                     events such as signal transduction, cytoskeleton dynamics
                     and intracellular trafficking; cd00155"
                     /db_xref="CDD:238087"
     Site            order(547..549,560..561,563..565,567..568,571..572,575,
                     608,611..612,614..616,618..621,623..624,644,647,652..654,
                     657,670..672,675..677,679..681,683..686,700,704,739,
                     742..743)
                     /site_type="other"
                     /note="Ras interaction site [polypeptide binding]"
                     /db_xref="CDD:238087"
     CDS             1..779
                     /gene="RAPGEF3"
                     /gene_synonym="bcm910; CAMP-GEFI; EPAC; EPAC1; HSU79275"
                     /coded_by="XM_054370770.1:177..2516"
                     /db_xref="GeneID:10411"
                     /db_xref="HGNC:HGNC:16629"
                     /db_xref="MIM:606057"
ORIGIN      
        1 mgswpwdlgs ipgaklwesa rccwmkvpsa mdrdaqfyrf pgpepepvgt hemeeelaea
       61 vallsqrgpd alltvalrkp pgqrtdeeld lifeellhik avahlsnsvk relaavllfe
      121 phskagtvlf sqgdkgtswy iiwkgsvnvv thgkglvttl hegddfgqla lvndapraat
      181 iilrednchf lrvdkqdfnr iikdveaktm rleehgkvvl vlerasqgas psrpptpgrn
      241 rytvmsgtpe kilellleam gpdssahdpt etflsdfllt hrvfmpsaql caallhhfhv
      301 epaggseqer styvcnkrqq ilrlvsqwva lygsmlhtdp vatsflqkls dlvgrdtrls
      361 nllreqwper rrchrlengc gnaspqmkar nlpvwlpnqd eplpgsscai qvgdkvpydi
      421 crpdhsvltl qlpvtasvre vmaalaqedg wtkgqvlvkv nsagdaiglq pdargvatsl
      481 glnerlfvvn pqevheliph pdqlgptvgs aegldlvsak dlagqltdhd wslfnsihqv
      541 elihyvlgpq hlrdvttanl erfmrrfnel qywvatelcl cpvpgpraql lrkfiklaah
      601 lkeqknlnsf favmfglsns aisrlahtwe rlphkvrkly salerlldps wnhrvyrlal
      661 aklsppvipf mplllkdmtf ihegnhtlve nlinfekmrm maraarmlhh crshnpvpls
      721 plrsrvshlh edsqvarist cseqslstrs pastwayvqq lkvidnqrel srlsrelep
//
LOCUS       XP_054226746             510 aa            linear   PRI 05-AUG-2025
DEFINITION  rap guanine nucleotide exchange factor 3 isoform X5 [Homo sapiens].
ACCESSION   XP_054226746
VERSION     XP_054226746.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370771.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..510
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..510
                     /product="rap guanine nucleotide exchange factor 3 isoform
                     X5"
                     /calculated_mol_wt=55785
     Region          100..238
                     /region_name="DEP_Epac"
                     /note="DEP (Dishevelled, Egl-10, and Pleckstrin) domain
                     found in Epac-like proteins. Epac (exchange proteins
                     directly activated by cAMP) proteins are GEFs
                     (guanine-nucleotide-exchange factors) for the small
                     GTPases, Rap1 and Rap2. They are directly regulated by...;
                     cd04437"
                     /db_xref="CDD:239884"
     Region          262..371
                     /region_name="CAP_ED"
                     /note="effector domain of the CAP family of transcription
                     factors; members include CAP (or cAMP receptor protein
                     (CRP)), which binds cAMP, FNR (fumarate and nitrate
                     reduction), which uses an iron-sulfur cluster to sense
                     oxygen) and CooA, a heme containing CO...; cd00038"
                     /db_xref="CDD:237999"
     Site            order(326..327,336..338)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:237999"
     Site            order(359..361,365..367)
                     /site_type="other"
                     /note="flexible hinge region"
                     /db_xref="CDD:237999"
     CDS             1..510
                     /gene="RAPGEF3"
                     /gene_synonym="bcm910; CAMP-GEFI; EPAC; EPAC1; HSU79275"
                     /coded_by="XM_054370771.1:325..1857"
                     /db_xref="GeneID:10411"
                     /db_xref="HGNC:HGNC:16629"
                     /db_xref="MIM:606057"
ORIGIN      
        1 mkvgwpgesc wqvglpveds palgaprvga lpdvvpegtl lnmvlrrmhr prscsyqlll
       61 ehqrpsciqg lrwtpltnse esldfsesle qastervlra grqlhrhlla tcpnlirdrk
      121 yhlrlyrqcc sgrelvdgil alglgvhsrs qvvgicqvll degalchasi ssppprlglc
      181 ppvkhdwafq drdaqfyrfp gpepepvgth emeeelaeav allsqrgpda lltvalrkpp
      241 gqrtdeeldl ifeellhika vahlsnsvkr elaavllfep hskagtvlfs qgdkgtswyi
      301 iwkgsvnvvt hgkglvttlh egddfgqlal vndapraati ilrednchfl rvdkqdfnri
      361 ikdveaktmr leehgkvvlv lerasqgasp srpptpgrnr ytvmsgtpek ilellleamg
      421 pdssahdptg sscpapnsal pfcttsmwsl rvaasrsaap tsatrgsrsc gwsasgwpcm
      481 apcstltlwp passrnsqtw wagtpdsatc
//
LOCUS       XP_054226747             495 aa            linear   PRI 05-AUG-2025
DEFINITION  rap guanine nucleotide exchange factor 3 isoform X6 [Homo sapiens].
ACCESSION   XP_054226747
VERSION     XP_054226747.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370772.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..495
                     /product="rap guanine nucleotide exchange factor 3 isoform
                     X6"
                     /calculated_mol_wt=55798
     Region          <1..83
                     /region_name="REM"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     GTPases; N-terminal domain (RasGef_N), also called REM
                     domain (Ras exchanger motif). This domain is common in
                     nucleotide exchange factors for Ras-like small GTPases and
                     is typically found immediately...; cd06224"
                     /db_xref="CDD:100121"
     Site            order(31,35..36,39,42..43,78..79,82)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:100121"
     Region          230..462
                     /region_name="RasGEF"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     small GTPases. Small GTP-binding proteins of the Ras
                     superfamily function as molecular switches in fundamental
                     events such as signal transduction, cytoskeleton dynamics
                     and intracellular trafficking; cd00155"
                     /db_xref="CDD:238087"
     Site            order(263..265,276..277,279..281,283..284,287..288,291,
                     324,327..328,330..332,334..337,339..340,360,363,368..370,
                     373,386..388,391..393,395..397,399..402,416,420,455,
                     458..459)
                     /site_type="other"
                     /note="Ras interaction site [polypeptide binding]"
                     /db_xref="CDD:238087"
     CDS             1..495
                     /gene="RAPGEF3"
                     /gene_synonym="bcm910; CAMP-GEFI; EPAC; EPAC1; HSU79275"
                     /coded_by="XM_054370772.1:97..1584"
                     /db_xref="GeneID:10411"
                     /db_xref="HGNC:HGNC:16629"
                     /db_xref="MIM:606057"
ORIGIN      
        1 mpsaqlcaal lhhfhvepag gseqerstyv cnkrqqilrl vsqwvalygs mlhtdpvats
       61 flqklsdlvg rdtrlsnllr eqwperrrch rlengcgnas pqmkarnlpv wlpnqdeplp
      121 gsscaiqvgd kvpydicrpd hsvltlqlpv tasvrevmaa laqedgwtkg qvlvkvnsag
      181 daiglqpdar gvatslglne rlfvvnpqev heliphpdql gptvgsaegl dlvsakdlag
      241 qltdhdwslf nsihqvelih yvlgpqhlrd vttanlerfm rrfnelqywv atelclcpvp
      301 gpraqllrkf iklaahlkeq knlnsffavm fglsnsaisr lahtwerlph kvrklysale
      361 rlldpswnhr vyrlalakls ppvipfmpll lkdmtfiheg nhtlvenlin fekmrmmara
      421 armlhhcrsh npvplsplrs rvshlhedsq varistcseq slstrspast wayvqqlkvi
      481 dnqrelsrls relep
//
LOCUS       XP_054226748             449 aa            linear   PRI 05-AUG-2025
DEFINITION  microspherule protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_054226748
VERSION     XP_054226748.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370773.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..449
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..449
                     /product="microspherule protein 1 isoform X1"
                     /calculated_mol_wt=50282
     Region          121..318
                     /region_name="MCRS_N"
                     /note="N-terminal region of micro-spherule protein;
                     pfam13325"
                     /db_xref="CDD:463845"
     Region          328..432
                     /region_name="FHA_MCRS1"
                     /note="forkhead associated (FHA) domain found in
                     microspherule protein 1 (MCRS1) and similar proteins;
                     cd22687"
                     /db_xref="CDD:438739"
     Site            order(353..354,375..376,378,395,397..398)
                     /site_type="other"
                     /note="putative phosphopeptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:438739"
     CDS             1..449
                     /gene="MCRS1"
                     /gene_synonym="ICP22BP; INO80Q; MCRS2; MSP58; P78"
                     /coded_by="XM_054370773.1:125..1474"
                     /db_xref="GeneID:10445"
                     /db_xref="HGNC:HGNC:6960"
                     /db_xref="MIM:609504"
ORIGIN      
        1 masgtasrse deeslagqkr assqalgtip krrsssrfik rkkfddelve sslaksstra
       61 kgasgvepgr csgsepssse kkkvskapst pvppspapap gltkrvkksk qplqvtkdlg
      121 rwkpaddlll inavlqtndl tsvhlgvkfs crftlrevqe rwyallydpv isklacqamr
      181 qlhpeaiaai qskalfskae eqllskvgst sqptletfqd llhrhpdafy lartakalqa
      241 hwqlmkqyyl ledqtvqplp kgdqvlnfsd aedliddskl kdmrdevleh elmvadrrqk
      301 reirqleqel hkwqvlvdsi tgmsspdfdn qtlavlrgrm vrylmrsrei tlgratkdnq
      361 idvdlslegp awkisrkqgv iklknngdff ianegrrpiy idgrpvlcgs kwrlsnnsvv
      421 eiaslrfvfl inqdlialir aeaakitpq
//
LOCUS       XP_054226749             475 aa            linear   PRI 05-AUG-2025
DEFINITION  microspherule protein 1 isoform X2 [Homo sapiens].
ACCESSION   XP_054226749
VERSION     XP_054226749.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370774.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..475
                     /product="microspherule protein 1 isoform X2"
                     /calculated_mol_wt=52870
     Region          147..344
                     /region_name="MCRS_N"
                     /note="N-terminal region of micro-spherule protein;
                     pfam13325"
                     /db_xref="CDD:463845"
     Region          354..458
                     /region_name="FHA_MCRS1"
                     /note="forkhead associated (FHA) domain found in
                     microspherule protein 1 (MCRS1) and similar proteins;
                     cd22687"
                     /db_xref="CDD:438739"
     Site            order(379..380,401..402,404,421,423..424)
                     /site_type="other"
                     /note="putative phosphopeptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:438739"
     CDS             1..475
                     /gene="MCRS1"
                     /gene_synonym="ICP22BP; INO80Q; MCRS2; MSP58; P78"
                     /coded_by="XM_054370774.1:601..2028"
                     /db_xref="GeneID:10445"
                     /db_xref="HGNC:HGNC:6960"
                     /db_xref="MIM:609504"
ORIGIN      
        1 mtrgtggtaq rgrsgpdsqg lldsslmasg tasrsedees lagqkrassq algtipkrrs
       61 ssrfikrkkf ddelvessla ksstrakgas gvepgrcsgs epsssekkkv skapstpvpp
      121 spapapgltk rvkkskqplq vtkdlgrwkp addlllinav lqtndltsvh lgvkfscrft
      181 lrevqerwya llydpviskl acqamrqlhp eaiaaiqska lfskaeeqll skvgstsqpt
      241 letfqdllhr hpdafylart akalqahwql mkqyylledq tvqplpkgdq vlnfsdaedl
      301 iddsklkdmr devlehelmv adrrqkreir qleqelhkwq vlvdsitgms spdfdnqtla
      361 vlrgrmvryl mrsreitlgr atkdnqidvd lslegpawki srkqgviklk nngdffiane
      421 grrpiyidgr pvlcgskwrl snnsvveias lrfvflinqd lialiraeaa kitpq
//
LOCUS       XP_054226750             462 aa            linear   PRI 05-AUG-2025
DEFINITION  microspherule protein 1 isoform X3 [Homo sapiens].
ACCESSION   XP_054226750
VERSION     XP_054226750.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370775.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..462
                     /product="microspherule protein 1 isoform X3"
                     /calculated_mol_wt=51672
     Region          134..331
                     /region_name="MCRS_N"
                     /note="N-terminal region of micro-spherule protein;
                     pfam13325"
                     /db_xref="CDD:463845"
     Region          341..445
                     /region_name="FHA_MCRS1"
                     /note="forkhead associated (FHA) domain found in
                     microspherule protein 1 (MCRS1) and similar proteins;
                     cd22687"
                     /db_xref="CDD:438739"
     Site            order(366..367,388..389,391,408,410..411)
                     /site_type="other"
                     /note="putative phosphopeptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:438739"
     CDS             1..462
                     /gene="MCRS1"
                     /gene_synonym="ICP22BP; INO80Q; MCRS2; MSP58; P78"
                     /coded_by="XM_054370775.1:309..1697"
                     /db_xref="GeneID:10445"
                     /db_xref="HGNC:HGNC:6960"
                     /db_xref="MIM:609504"
ORIGIN      
        1 mdkdsqglld sslmasgtas rsedeeslag qkrassqalg tipkrrsssr fikrkkfdde
       61 lvesslakss trakgasgve pgrcsgseps ssekkkvska pstpvppspa papgltkrvk
      121 kskqplqvtk dlgrwkpadd lllinavlqt ndltsvhlgv kfscrftlre vqerwyally
      181 dpvisklacq amrqlhpeai aaiqskalfs kaeeqllskv gstsqptlet fqdllhrhpd
      241 afylartaka lqahwqlmkq yylledqtvq plpkgdqvln fsdaedlidd sklkdmrdev
      301 lehelmvadr rqkreirqle qelhkwqvlv dsitgmsspd fdnqtlavlr grmvrylmrs
      361 reitlgratk dnqidvdlsl egpawkisrk qgviklknng dffianegrr piyidgrpvl
      421 cgskwrlsnn svveiaslrf vflinqdlia liraeaakit pq
//
LOCUS       XP_054226751             267 aa            linear   PRI 05-AUG-2025
DEFINITION  microspherule protein 1 isoform X4 [Homo sapiens].
ACCESSION   XP_054226751
VERSION     XP_054226751.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370776.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..267
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..267
                     /product="microspherule protein 1 isoform X4"
                     /calculated_mol_wt=29196
     Region          121..>267
                     /region_name="MCRS_N"
                     /note="N-terminal region of micro-spherule protein;
                     pfam13325"
                     /db_xref="CDD:463845"
     CDS             1..267
                     /gene="MCRS1"
                     /gene_synonym="ICP22BP; INO80Q; MCRS2; MSP58; P78"
                     /coded_by="XM_054370776.1:125..928"
                     /db_xref="GeneID:10445"
                     /db_xref="HGNC:HGNC:6960"
                     /db_xref="MIM:609504"
ORIGIN      
        1 masgtasrse deeslagqkr assqalgtip krrsssrfik rkkfddelve sslaksstra
       61 kgasgvepgr csgsepssse kkkvskapst pvppspapap gltkrvkksk qplqvtkdlg
      121 rwkpaddlll inavlqtndl tsvhlgvkfs crftlrevqe rwyallydpv isklacqamr
      181 qlhpeaiaai qskalfskae eqllskvgst sqptletfqd llhrhpdafy lartakalqa
      241 hwqlmkqyyl ledqtaaaqr gpsaell
//
LOCUS       XP_054226752            1020 aa            linear   PRI 05-AUG-2025
DEFINITION  importin-8 isoform X1 [Homo sapiens].
ACCESSION   XP_054226752
VERSION     XP_054226752.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370777.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1020
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1020
                     /product="importin-8 isoform X1"
                     /calculated_mol_wt=118028
     Region          14..979
                     /region_name="SXM1"
                     /note="Importin, protein involved in nuclear import
                     [Posttranslational modification, protein turnover,
                     chaperones]; COG5656"
                     /db_xref="CDD:227943"
     CDS             1..1020
                     /gene="IPO8"
                     /gene_synonym="RANBP8; VISS"
                     /coded_by="XM_054370777.1:318..3380"
                     /db_xref="GeneID:10526"
                     /db_xref="HGNC:HGNC:9853"
                     /db_xref="MIM:605600"
ORIGIN      
        1 mvillylrhi ksykiinfap sllriivsdh vefpvrqaaa iylknmvtqy wpdrepppge
       61 aifpfnihen drqqirdniv egiirspdlv rvqltmclra iikhdfpghw pgvvdkidyy
      121 lqsqssaswl gsllclyqlv ktyeykkaee repliiamqi flpriqqqiv qllpdssyys
      181 vllqkqilki fyalvqyalp lqlvnnqtmt twmeifrtii drtvppetlh ideddrpelv
      241 wwkckkwalh ivarlferyg spgnvtkeyf efsefflkty avgiqqvllk ildqyrqkey
      301 vaprvlqqaf nylnqgvvhs itwkqmkphi qnisedvifs vmcykdedee lwqedpyeyi
      361 rmkfdifedy aspttaaqtl lytaakkrke vlpkmmafcy qiltdpnfdp rkkdgalhvi
      421 gslaeillkk slfkdqmelf lqnhvfplll snlgylrars cwvlhafssl kfhnelnlrn
      481 avelakksli edkempvkve aalalqslis nqiqakeymk phvrpimqel lhivretend
      541 dvtnviqkmi ceysqevasi avdmtqhlae ifgkvlqsde yeevedktvm amgilhtidt
      601 iltvvedhke itqqlenicl riidlvlqkh viefyeeils laysltchsi spqmwqllgi
      661 lyevfqqdcf eyftdmmpll hnyvtidtdt llsnakhlei lftmcrkvlc gdagedaech
      721 aaklleviil qckgrgidqc iplfvqlvle rltrgvktse lrtmclqvai aalyynpdll
      781 lhtleriqlp hnpgpitvqf inqwmndtdc flghhdrkmc iiglsillel qnrppavdav
      841 vgqivpsilf lflglkqvca trqlvnredr skaekadmee neeissdeee tnvtaqamqs
      901 nngrgedeee edddwdeevl eetalegfst pldldnsvde yqfftqalit vqsrdaawyq
      961 llmaplsedq rtalqevytl aehrrtvaea kkkieqqggf tfenkgvlsa fnfgtvpsnn
//
LOCUS       XP_054226753            1009 aa            linear   PRI 05-AUG-2025
DEFINITION  importin-8 isoform X4 [Homo sapiens].
ACCESSION   XP_054226753
VERSION     XP_054226753.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370778.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1009
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1009
                     /product="importin-8 isoform X4"
                     /calculated_mol_wt=116749
     Region          15..996
                     /region_name="SXM1"
                     /note="Importin, protein involved in nuclear import
                     [Posttranslational modification, protein turnover,
                     chaperones]; COG5656"
                     /db_xref="CDD:227943"
     CDS             1..1009
                     /gene="IPO8"
                     /gene_synonym="RANBP8; VISS"
                     /coded_by="XM_054370778.1:223..3252"
                     /db_xref="GeneID:10526"
                     /db_xref="HGNC:HGNC:9853"
                     /db_xref="MIM:605600"
ORIGIN      
        1 mdlnriiqal kgtidpklri aaenelnqsy kiinfapsll riivsdhvef pvrqaaaiyl
       61 knmvtqywpd repppgeaif pfnihendrq qirdnivegi irspdlvrvq ltmclraiik
      121 hdfpghwpgv vdkidyylqs qssaswlgsl lclyqlvkty eykkaeerep liiamqiflp
      181 riqqqivqll pdssyysvll qkqilkifya lvqyalplql vnnqtmttwm eifrtiidrt
      241 vppetlhide ddrpelvwwk ckkwalhiva rlferygspg nvtkeyfefs efflktyavg
      301 iqqvllkild qyrqkeyvap rvlqqafnyl nqgvvhsitw kqmkphiqni sedvifsvmc
      361 ykdedeelwq edpyeyirmk fdifedyasp ttaaqtllyt aakkrkevlp kmmafcyqil
      421 tdpnfdprkk dgalhvigsl aeillkkslf kdqmelflqn hvfplllsnl gylrarscwv
      481 lhafsslkfh nelnlrnave lakksliedk empvkveaal alqslisnqi qakeymkphv
      541 rpimqellhi vretenddvt nviqkmicey sqevasiavd mtqhlaeifg kvlqsdeyee
      601 vedktvmamg ilhtidtilt vvedhkeitq qleniclrii dlvlqkhvie fyeeilslay
      661 sltchsispq mwqllgilye vfqqdcfeyf tdmmpllhny vtidtdtlls nakhleilft
      721 mcrkvlcgda gedaechaak lleviilqck grgidqcipl fvqlvlerlt rgvktselrt
      781 mclqvaiaal yynpdlllht leriqlphnp gpitvqfinq wmndtdcflg hhdrkmciig
      841 lsillelqnr ppavdavvgq ivpsilflfl glkqvcatrq lvnredrska ekadmeenee
      901 issdeeetnv taqamqsnng rgedeeeedd dwdeevleet alegfstpld ldnsvdeyqf
      961 ftqalitvqs rdaawyqllm aplsedqrta lqevytlaeh rrtvagqpe
//
LOCUS       XP_054226754             975 aa            linear   PRI 05-AUG-2025
DEFINITION  importin-8 isoform X2 [Homo sapiens].
ACCESSION   XP_054226754
VERSION     XP_054226754.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370779.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..975
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..975
                     /product="importin-8 isoform X2"
                     /calculated_mol_wt=112777
     Region          15..934
                     /region_name="SXM1"
                     /note="Importin, protein involved in nuclear import
                     [Posttranslational modification, protein turnover,
                     chaperones]; COG5656"
                     /db_xref="CDD:227943"
     CDS             1..975
                     /gene="IPO8"
                     /gene_synonym="RANBP8; VISS"
                     /coded_by="XM_054370779.1:112..3039"
                     /db_xref="GeneID:10526"
                     /db_xref="HGNC:HGNC:9853"
                     /db_xref="MIM:605600"
ORIGIN      
        1 mvtqywpdre pppgeaifpf nihendrqqi rdnivegiir spdlvrvqlt mclraiikhd
       61 fpghwpgvvd kidyylqsqs saswlgsllc lyqlvktyey kkaeerepli iamqiflpri
      121 qqqivqllpd ssyysvllqk qilkifyalv qyalplqlvn nqtmttwmei frtiidrtvp
      181 petlhidedd rpelvwwkck kwalhivarl ferygspgnv tkeyfefsef flktyavgiq
      241 qvllkildqy rqkeyvaprv lqqafnylnq gvvhsitwkq mkphiqnise dvifsvmcyk
      301 dedeelwqed pyeyirmkfd ifedyasptt aaqtllytaa kkrkevlpkm mafcyqiltd
      361 pnfdprkkdg alhvigslae illkkslfkd qmelflqnhv fplllsnlgy lrarscwvlh
      421 afsslkfhne lnlrnavela kksliedkem pvkveaalal qslisnqiqa keymkphvrp
      481 imqellhivr etenddvtnv iqkmiceysq evasiavdmt qhlaeifgkv lqsdeyeeve
      541 dktvmamgil htidtiltvv edhkeitqql eniclriidl vlqkhviefy eeilslaysl
      601 tchsispqmw qllgilyevf qqdcfeyftd mmpllhnyvt idtdtllsna khleilftmc
      661 rkvlcgdage daechaakll eviilqckgr gidqciplfv qlvlerltrg vktselrtmc
      721 lqvaiaalyy npdlllhtle riqlphnpgp itvqfinqwm ndtdcflghh drkmciigls
      781 illelqnrpp avdavvgqiv psilflflgl kqvcatrqlv nredrskaek admeeneeis
      841 sdeeetnvta qamqsnngrg edeeeedddw deevleetal egfstpldld nsvdeyqfft
      901 qalitvqsrd aawyqllmap lsedqrtalq evytlaehrr tvaeakkkie qqggftfenk
      961 gvlsafnfgt vpsnn
//
LOCUS       XP_054226755             532 aa            linear   PRI 05-AUG-2025
DEFINITION  importin-8 isoform X3 [Homo sapiens].
ACCESSION   XP_054226755
VERSION     XP_054226755.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370780.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..532
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..532
                     /product="importin-8 isoform X3"
                     /calculated_mol_wt=62098
     Region          15..>528
                     /region_name="SXM1"
                     /note="Importin, protein involved in nuclear import
                     [Posttranslational modification, protein turnover,
                     chaperones]; COG5656"
                     /db_xref="CDD:227943"
     CDS             1..532
                     /gene="IPO8"
                     /gene_synonym="RANBP8; VISS"
                     /coded_by="XM_054370780.1:223..1821"
                     /db_xref="GeneID:10526"
                     /db_xref="HGNC:HGNC:9853"
                     /db_xref="MIM:605600"
ORIGIN      
        1 mdlnriiqal kgtidpklri aaenelnqsy kiinfapsll riivsdhvef pvrqaaaiyl
       61 knmvtqywpd repppgeaif pfnihendrq qirdnivegi irspdlvrvq ltmclraiik
      121 hdfpghwpgv vdkidyylqs qssaswlgsl lclyqlvkty eykkaeerep liiamqiflp
      181 riqqqivqll pdssyysvll qkqilkifya lvqyalplql vnnqtmttwm eifrtiidrt
      241 vppetlhide ddrpelvwwk ckkwalhiva rlferygspg nvtkeyfefs efflktyavg
      301 iqqvllkild qyrqkeyvap rvlqqafnyl nqgvvhsitw kqmkphiqni sedvifsvmc
      361 ykdedeelwq edpyeyirmk fdifedyasp ttaaqtllyt aakkrkevlp kmmafcyqil
      421 tdpnfdprkk dgalhvigsl aeillkkslf kdqmelflqn hvfplllsnl gylrarscwv
      481 lhafsslkfh nelnlrnave lakksliedk empvkveaal alqslisnqi qg
//
LOCUS       XP_054226756             320 aa            linear   PRI 05-AUG-2025
DEFINITION  dynactin subunit 2 isoform X1 [Homo sapiens].
ACCESSION   XP_054226756
VERSION     XP_054226756.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370781.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..320
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..320
                     /product="dynactin subunit 2 isoform X1"
                     /calculated_mol_wt=34716
     Region          16..>313
                     /region_name="Dynamitin"
                     /note="pfam04912"
                     /db_xref="CDD:461477"
     CDS             1..320
                     /gene="DCTN2"
                     /gene_synonym="DCTN50; DYNAMITIN; HEL-S-77; RBP50"
                     /coded_by="XM_054370781.1:130..1092"
                     /db_xref="GeneID:10540"
                     /db_xref="HGNC:HGNC:2712"
                     /db_xref="MIM:607376"
ORIGIN      
        1 madpkyadlp giarnepdvy etsdlpeddq aefdafaqel eeltstsveh iivnpnaayd
       61 kfkdkrvgtk gldfsdrigk tkrtgyesge yemlgeglgv ketpqqkyqr llhevqeltt
      121 evekikttvk esateekltp vllakqlaal kqqlvashle kllgpdaain ltdpdgalak
      181 rlllqleatk nskggsggkt tgtppdsslv tyelhsrpeq dkfsqaakva elekrltele
      241 tavrcdqdaq nplsaglqga clmetvellq akvsaldlav ldqvearlqs vlgkvneiak
      301 hkasvedadt qskpcslvss
//
LOCUS       XP_054226757             368 aa            linear   PRI 05-AUG-2025
DEFINITION  RAD51-associated protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_054226757
VERSION     XP_054226757.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370782.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..368
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..368
                     /product="RAD51-associated protein 1 isoform X1"
                     /calculated_mol_wt=40063
     Region          <344..365
                     /region_name="RAD51_interact"
                     /note="RAD51 interacting motif; pfam15696"
                     /db_xref="CDD:464808"
     CDS             1..368
                     /gene="RAD51AP1"
                     /gene_synonym="PIR51"
                     /coded_by="XM_054370782.1:51..1157"
                     /db_xref="GeneID:10635"
                     /db_xref="HGNC:HGNC:16956"
                     /db_xref="MIM:603070"
ORIGIN      
        1 mvrpvrhkkp vnysqfdhsd sdddfvsatv plnkksrtap kelkqdkpkp nlnnlrkeei
       61 pvqektpkkr lpegtfsipa savpctkmal ddklyqrdle valalsvkel ptvttnvqns
      121 qdksiekhgs skietmnksp hisncsvasd yldldkitve ddvggvqgkr kaaskaaaqq
      181 rkillegsdg dsandtepdf apgedsedds dfcesednde dfsmrkskvk eikkkevkvk
      241 spvekkekks kskcnalvts vdsapaavks esqslpkkvs lssdttrkpl eirspsaesk
      301 kpkwvppgma ylssrtgawk iitaasggsr ssssplvvvs vkspnqslrl glsrlarvkp
      361 lhpnatst
//
LOCUS       XP_054226758             351 aa            linear   PRI 05-AUG-2025
DEFINITION  RAD51-associated protein 1 isoform X2 [Homo sapiens].
ACCESSION   XP_054226758
VERSION     XP_054226758.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370783.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..351
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..351
                     /product="RAD51-associated protein 1 isoform X2"
                     /calculated_mol_wt=38363
     Region          <327..348
                     /region_name="RAD51_interact"
                     /note="RAD51 interacting motif; pfam15696"
                     /db_xref="CDD:464808"
     CDS             1..351
                     /gene="RAD51AP1"
                     /gene_synonym="PIR51"
                     /coded_by="XM_054370783.1:51..1106"
                     /db_xref="GeneID:10635"
                     /db_xref="HGNC:HGNC:16956"
                     /db_xref="MIM:603070"
ORIGIN      
        1 mvrpvrhkkp vnysqfdhsd sdddfvsatv plnkksrtap kelkqdkpkp nlnnlrkeei
       61 pvqektpkkr malddklyqr dlevalalsv kelptvttnv qnsqdksiek hgsskietmn
      121 ksphisncsv asdyldldki tveddvggvq gkrkaaskaa aqqrkilleg sdgdsandte
      181 pdfapgedse ddsdfcesed ndedfsmrks kvkeikkkev kvkspvekke kkskskcnal
      241 vtsvdsapaa vksesqslpk kvslssdttr kpleirspsa eskkpkwvpp gmaylssrtg
      301 awkiitaasg gsrssssplv vvsvkspnqs lrlglsrlar vkplhpnats t
//
LOCUS       XP_054226759             314 aa            linear   PRI 05-AUG-2025
DEFINITION  RAD51-associated protein 1 isoform X3 [Homo sapiens].
ACCESSION   XP_054226759
VERSION     XP_054226759.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370784.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..314
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..314
                     /product="RAD51-associated protein 1 isoform X3"
                     /calculated_mol_wt=33790
     Region          <290..311
                     /region_name="RAD51_interact"
                     /note="RAD51 interacting motif; pfam15696"
                     /db_xref="CDD:464808"
     CDS             1..314
                     /gene="RAD51AP1"
                     /gene_synonym="PIR51"
                     /coded_by="XM_054370784.1:138..1082"
                     /db_xref="GeneID:10635"
                     /db_xref="HGNC:HGNC:16956"
                     /db_xref="MIM:603070"
ORIGIN      
        1 mnlgniilse rsqiyrlpeg tfsipasavp ctkmalddkl yqrdlevala lsvkelptvt
       61 tnvqnsqdks iekhgsskie tmnksphisn csvasdyldl dkitveddvg gvqgkrkaas
      121 kaaaqqrkil legsdgdsan dtepdfapge dseddsdfce sedndedfsm rkskvkeikk
      181 kevkvkspve kkekkskskc nalvtsvdsa paavksesqs lpkkvslssd ttrkpleirs
      241 psaeskkpkw vppgmaylss rtgawkiita asggsrssss plvvvsvksp nqslrlglsr
      301 larvkplhpn atst
//
LOCUS       XP_054226760             314 aa            linear   PRI 05-AUG-2025
DEFINITION  RAD51-associated protein 1 isoform X3 [Homo sapiens].
ACCESSION   XP_054226760
VERSION     XP_054226760.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370785.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..314
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..314
                     /product="RAD51-associated protein 1 isoform X3"
                     /calculated_mol_wt=33790
     Region          <290..311
                     /region_name="RAD51_interact"
                     /note="RAD51 interacting motif; pfam15696"
                     /db_xref="CDD:464808"
     CDS             1..314
                     /gene="RAD51AP1"
                     /gene_synonym="PIR51"
                     /coded_by="XM_054370785.1:118..1062"
                     /db_xref="GeneID:10635"
                     /db_xref="HGNC:HGNC:16956"
                     /db_xref="MIM:603070"
ORIGIN      
        1 mnlgniilse rsqiyrlpeg tfsipasavp ctkmalddkl yqrdlevala lsvkelptvt
       61 tnvqnsqdks iekhgsskie tmnksphisn csvasdyldl dkitveddvg gvqgkrkaas
      121 kaaaqqrkil legsdgdsan dtepdfapge dseddsdfce sedndedfsm rkskvkeikk
      181 kevkvkspve kkekkskskc nalvtsvdsa paavksesqs lpkkvslssd ttrkpleirs
      241 psaeskkpkw vppgmaylss rtgawkiita asggsrssss plvvvsvksp nqslrlglsr
      301 larvkplhpn atst
//
LOCUS       XP_054226761             302 aa            linear   PRI 05-AUG-2025
DEFINITION  RAD51-associated protein 1 isoform X4 [Homo sapiens].
ACCESSION   XP_054226761
VERSION     XP_054226761.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370786.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..302
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..302
                     /product="RAD51-associated protein 1 isoform X4"
                     /calculated_mol_wt=33011
     Region          <278..299
                     /region_name="RAD51_interact"
                     /note="RAD51 interacting motif; pfam15696"
                     /db_xref="CDD:464808"
     CDS             1..302
                     /gene="RAD51AP1"
                     /gene_synonym="PIR51"
                     /coded_by="XM_054370786.1:51..959"
                     /db_xref="GeneID:10635"
                     /db_xref="HGNC:HGNC:16956"
                     /db_xref="MIM:603070"
ORIGIN      
        1 mvrpvrhkkp vnysqfdhsd sdddfvsatv plnkksrtap kelkqdkpkp nlnnlrkeei
       61 pvqektpkkr lpegtfsipa savpctkmal ddklyqrdle valalsvkel ptvttnvqns
      121 qdksiekhgs skietmnksp hisncsvasd yldldkitve ddvggvqgkr kaaskaaaqq
      181 rkillegsdg dsandtepdf apgedsedds dfcesednde dfsmrkskvk eikkkevkvk
      241 spvekkekks kskcnalaas ggsrsssspl vvvsvkspnq slrlglsrla rvkplhpnat
      301 st
//
LOCUS       XP_054226762             285 aa            linear   PRI 05-AUG-2025
DEFINITION  RAD51-associated protein 1 isoform X5 [Homo sapiens].
ACCESSION   XP_054226762
VERSION     XP_054226762.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370787.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..285
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..285
                     /product="RAD51-associated protein 1 isoform X5"
                     /calculated_mol_wt=31311
     Region          <261..282
                     /region_name="RAD51_interact"
                     /note="RAD51 interacting motif; pfam15696"
                     /db_xref="CDD:464808"
     CDS             1..285
                     /gene="RAD51AP1"
                     /gene_synonym="PIR51"
                     /coded_by="XM_054370787.1:51..908"
                     /db_xref="GeneID:10635"
                     /db_xref="HGNC:HGNC:16956"
                     /db_xref="MIM:603070"
ORIGIN      
        1 mvrpvrhkkp vnysqfdhsd sdddfvsatv plnkksrtap kelkqdkpkp nlnnlrkeei
       61 pvqektpkkr malddklyqr dlevalalsv kelptvttnv qnsqdksiek hgsskietmn
      121 ksphisncsv asdyldldki tveddvggvq gkrkaaskaa aqqrkilleg sdgdsandte
      181 pdfapgedse ddsdfcesed ndedfsmrks kvkeikkkev kvkspvekke kkskskcnal
      241 aasggsrsss splvvvsvks pnqslrlgls rlarvkplhp natst
//
LOCUS       XP_054226763             281 aa            linear   PRI 05-AUG-2025
DEFINITION  RAD51-associated protein 1 isoform X6 [Homo sapiens].
ACCESSION   XP_054226763
VERSION     XP_054226763.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370788.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..281
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..281
                     /product="RAD51-associated protein 1 isoform X6"
                     /calculated_mol_wt=30201
     Region          <257..278
                     /region_name="RAD51_interact"
                     /note="RAD51 interacting motif; pfam15696"
                     /db_xref="CDD:464808"
     CDS             1..281
                     /gene="RAD51AP1"
                     /gene_synonym="PIR51"
                     /coded_by="XM_054370788.1:91..936"
                     /db_xref="GeneID:10635"
                     /db_xref="HGNC:HGNC:16956"
                     /db_xref="MIM:603070"
ORIGIN      
        1 malddklyqr dlevalalsv kelptvttnv qnsqdksiek hgsskietmn ksphisncsv
       61 asdyldldki tveddvggvq gkrkaaskaa aqqrkilleg sdgdsandte pdfapgedse
      121 ddsdfcesed ndedfsmrks kvkeikkkev kvkspvekke kkskskcnal vtsvdsapaa
      181 vksesqslpk kvslssdttr kpleirspsa eskkpkwvpp gmaylssrtg awkiitaasg
      241 gsrssssplv vvsvkspnqs lrlglsrlar vkplhpnats t
//
LOCUS       XP_054226764             281 aa            linear   PRI 05-AUG-2025
DEFINITION  RAD51-associated protein 1 isoform X6 [Homo sapiens].
ACCESSION   XP_054226764
VERSION     XP_054226764.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370789.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..281
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..281
                     /product="RAD51-associated protein 1 isoform X6"
                     /calculated_mol_wt=30201
     Region          <257..278
                     /region_name="RAD51_interact"
                     /note="RAD51 interacting motif; pfam15696"
                     /db_xref="CDD:464808"
     CDS             1..281
                     /gene="RAD51AP1"
                     /gene_synonym="PIR51"
                     /coded_by="XM_054370789.1:162..1007"
                     /db_xref="GeneID:10635"
                     /db_xref="HGNC:HGNC:16956"
                     /db_xref="MIM:603070"
ORIGIN      
        1 malddklyqr dlevalalsv kelptvttnv qnsqdksiek hgsskietmn ksphisncsv
       61 asdyldldki tveddvggvq gkrkaaskaa aqqrkilleg sdgdsandte pdfapgedse
      121 ddsdfcesed ndedfsmrks kvkeikkkev kvkspvekke kkskskcnal vtsvdsapaa
      181 vksesqslpk kvslssdttr kpleirspsa eskkpkwvpp gmaylssrtg awkiitaasg
      241 gsrssssplv vvsvkspnqs lrlglsrlar vkplhpnats t
//
LOCUS       XP_054226765             265 aa            linear   PRI 05-AUG-2025
DEFINITION  RAD51-associated protein 1 isoform X7 [Homo sapiens].
ACCESSION   XP_054226765
VERSION     XP_054226765.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370790.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..265
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..265
                     /product="RAD51-associated protein 1 isoform X7"
                     /calculated_mol_wt=28464
     Region          <241..262
                     /region_name="RAD51_interact"
                     /note="RAD51 interacting motif; pfam15696"
                     /db_xref="CDD:464808"
     CDS             1..265
                     /gene="RAD51AP1"
                     /gene_synonym="PIR51"
                     /coded_by="XM_054370790.1:162..959"
                     /db_xref="GeneID:10635"
                     /db_xref="HGNC:HGNC:16956"
                     /db_xref="MIM:603070"
ORIGIN      
        1 malddklyqr dlevalalsv kelptvttnv qnsqdksiek hgsskietmn ksphisncsv
       61 asdyldldki tveddvggvq gkrkaaskaa aqqrkilleg sdgdsandte pdfapgedse
      121 ddsdfcesed ndedfsmrks kvkeikkkev kvkspvekke kkskskcnal vtsvdsapaa
      181 vksesqslpk kvslssdttr kpleirspsa eskkpkwvpp aasggsrsss splvvvsvks
      241 pnqslrlgls rlarvkplhp natst
//
LOCUS       XP_054226766             265 aa            linear   PRI 05-AUG-2025
DEFINITION  RAD51-associated protein 1 isoform X7 [Homo sapiens].
ACCESSION   XP_054226766
VERSION     XP_054226766.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370791.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..265
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..265
                     /product="RAD51-associated protein 1 isoform X7"
                     /calculated_mol_wt=28464
     Region          <241..262
                     /region_name="RAD51_interact"
                     /note="RAD51 interacting motif; pfam15696"
                     /db_xref="CDD:464808"
     CDS             1..265
                     /gene="RAD51AP1"
                     /gene_synonym="PIR51"
                     /coded_by="XM_054370791.1:91..888"
                     /db_xref="GeneID:10635"
                     /db_xref="HGNC:HGNC:16956"
                     /db_xref="MIM:603070"
ORIGIN      
        1 malddklyqr dlevalalsv kelptvttnv qnsqdksiek hgsskietmn ksphisncsv
       61 asdyldldki tveddvggvq gkrkaaskaa aqqrkilleg sdgdsandte pdfapgedse
      121 ddsdfcesed ndedfsmrks kvkeikkkev kvkspvekke kkskskcnal vtsvdsapaa
      181 vksesqslpk kvslssdttr kpleirspsa eskkpkwvpp aasggsrsss splvvvsvks
      241 pnqslrlgls rlarvkplhp natst
//
LOCUS       XP_054226767             252 aa            linear   PRI 05-AUG-2025
DEFINITION  RAD51-associated protein 1 isoform X8 [Homo sapiens].
ACCESSION   XP_054226767
VERSION     XP_054226767.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370792.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..252
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..252
                     /product="RAD51-associated protein 1 isoform X8"
                     /calculated_mol_wt=28001
     CDS             1..252
                     /gene="RAD51AP1"
                     /gene_synonym="PIR51"
                     /coded_by="XM_054370792.1:51..809"
                     /db_xref="GeneID:10635"
                     /db_xref="HGNC:HGNC:16956"
                     /db_xref="MIM:603070"
ORIGIN      
        1 mvrpvrhkkp vnysqfdhsd sdddfvsatv plnkksrtap kelkqdkpkp nlnnlrkeei
       61 pvqektpkkr lpegtfsipa savpctkmal ddklyqrdle valalsvkel ptvttnvqns
      121 qdksiekhgs skietmnksp hisncsvasd yldldkitve ddvggvqgkr kaaskaaaqq
      181 rkillegsdg dsandtepdf apgedsedds dfcesednde dfsmrkskvk eikkkevkrh
      241 levaevaaah ww
//
LOCUS       XP_054226768             238 aa            linear   PRI 05-AUG-2025
DEFINITION  RAD51-associated protein 1 isoform X9 [Homo sapiens].
ACCESSION   XP_054226768
VERSION     XP_054226768.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370793.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..238
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..238
                     /product="RAD51-associated protein 1 isoform X9"
                     /calculated_mol_wt=26344
     CDS             1..238
                     /gene="RAD51AP1"
                     /gene_synonym="PIR51"
                     /coded_by="XM_054370793.1:51..767"
                     /db_xref="GeneID:10635"
                     /db_xref="HGNC:HGNC:16956"
                     /db_xref="MIM:603070"
ORIGIN      
        1 mvrpvrhkkp vnysqfdhsd sdddfvsatv plnkksrtap kelkqdkpkp nlnnlrkeei
       61 pvqektpkkr lpegtfsipa savpctkmal ddklyqrdle valalsvkel ptvttnvqns
      121 qdksiekhgs skietmnksp hisncsvasd yldldkitve ddvggvqgkr kaaskaaaqq
      181 rkillegsdg dsandtepdf apgedsedds dfcesednde dfsmrkskvk eikkkevk
//
LOCUS       XP_054226769             233 aa            linear   PRI 05-AUG-2025
DEFINITION  RAD51-associated protein 1 isoform X10 [Homo sapiens].
ACCESSION   XP_054226769
VERSION     XP_054226769.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370794.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..233
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..233
                     /product="RAD51-associated protein 1 isoform X10"
                     /calculated_mol_wt=24874
     Region          <209..230
                     /region_name="RAD51_interact"
                     /note="RAD51 interacting motif; pfam15696"
                     /db_xref="CDD:464808"
     CDS             1..233
                     /gene="RAD51AP1"
                     /gene_synonym="PIR51"
                     /coded_by="XM_054370794.1:135..836"
                     /db_xref="GeneID:10635"
                     /db_xref="HGNC:HGNC:16956"
                     /db_xref="MIM:603070"
ORIGIN      
        1 mnksphisnc svasdyldld kitveddvgg vqgkrkaask aaaqqrkill egsdgdsand
       61 tepdfapged seddsdfces edndedfsmr kskvkeikkk evkvkspvek kekkskskcn
      121 alvtsvdsap aavksesqsl pkkvslssdt trkpleirsp saeskkpkwv ppgmaylssr
      181 tgawkiitaa sggsrssssp lvvvsvkspn qslrlglsrl arvkplhpna tst
//
LOCUS       XP_054226770             221 aa            linear   PRI 05-AUG-2025
DEFINITION  RAD51-associated protein 1 isoform X11 [Homo sapiens].
ACCESSION   XP_054226770
VERSION     XP_054226770.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370795.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..221
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..221
                     /product="RAD51-associated protein 1 isoform X11"
                     /calculated_mol_wt=24644
     CDS             1..221
                     /gene="RAD51AP1"
                     /gene_synonym="PIR51"
                     /coded_by="XM_054370795.1:51..716"
                     /db_xref="GeneID:10635"
                     /db_xref="HGNC:HGNC:16956"
                     /db_xref="MIM:603070"
ORIGIN      
        1 mvrpvrhkkp vnysqfdhsd sdddfvsatv plnkksrtap kelkqdkpkp nlnnlrkeei
       61 pvqektpkkr malddklyqr dlevalalsv kelptvttnv qnsqdksiek hgsskietmn
      121 ksphisncsv asdyldldki tveddvggvq gkrkaaskaa aqqrkilleg sdgdsandte
      181 pdfapgedse ddsdfcesed ndedfsmrks kvkeikkkev k
//
LOCUS       XP_054226771             588 aa            linear   PRI 05-AUG-2025
DEFINITION  calcium/calmodulin-dependent protein kinase kinase 2 isoform X1
            [Homo sapiens].
ACCESSION   XP_054226771
VERSION     XP_054226771.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370796.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..588
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..588
                     /product="calcium/calmodulin-dependent protein kinase
                     kinase 2 isoform X1"
                     /calculated_mol_wt=64615
     Region          162..447
                     /region_name="STKc_CaMKK2"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calmodulin Dependent Protein Kinase Kinase 2; cd14199"
                     /db_xref="CDD:271101"
     Site            order(171..175,179,192,194,249,267..270,274,276,312,314,
                     316..317,319,330,333,349..352)
                     /site_type="active"
                     /db_xref="CDD:271101"
     Site            order(171..175,179,192,194,249,267..270,274,312,314,
                     316..317,319,330)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271101"
     Site            order(175,274,276,312,314,316,333,349..352)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:271101"
     Site            329..352
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:271101"
     CDS             1..588
                     /gene="CAMKK2"
                     /gene_synonym="CAMKK; CAMKKB"
                     /coded_by="XM_054370796.1:255..2021"
                     /db_xref="GeneID:10645"
                     /db_xref="HGNC:HGNC:1470"
                     /db_xref="MIM:615002"
ORIGIN      
        1 msscvssqps snraapqdel ggrgsssses qkpcealrgl sslsihlgme sfivvtecep
       61 gcavdlglar drpleadgqe vpldtsgsqa rphlsgrkls lqersqggla aggsldmngr
      121 cicpslpysp vsspqssprl prrptveshh vsitgmqdcv qlnqytlkde igkgsygvvk
      181 laynendnty yamkvlskkk lirqagfprr ppprgtrpap ggciqprgpi eqvyqeiail
      241 kkldhpnvvk lvevlddpne dhlymvfelv nqgpvmevpt lkplsedqar fyfqdlikgi
      301 eylhyqkiih rdikpsnllv gedghikiad fgvsnefkgs dallsntvgt pafmapesls
      361 etrkifsgka ldvwamgvtl ycfvfgqcpf mderimclhs kiksqalefp dqpdiaedlk
      421 dlitrmldkn pesrivvpei klhpwvtrhg aeplpseden ctlvevteee vensvkhips
      481 latvilvktm irkrsfgnpf egsrreersl sapgnlltkk ptreceslse lkearqrrqp
      541 pghrpaprgg ggsalvrgsp cvescwapap gsparmhplr peeamepe
//
LOCUS       XP_054226772             556 aa            linear   PRI 05-AUG-2025
DEFINITION  calcium/calmodulin-dependent protein kinase kinase 2 isoform X2
            [Homo sapiens].
ACCESSION   XP_054226772
VERSION     XP_054226772.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370797.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..556
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..556
                     /product="calcium/calmodulin-dependent protein kinase
                     kinase 2 isoform X2"
                     /calculated_mol_wt=61255
     Region          162..447
                     /region_name="STKc_CaMKK2"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calmodulin Dependent Protein Kinase Kinase 2; cd14199"
                     /db_xref="CDD:271101"
     Site            order(171..175,179,192,194,249,267..270,274,276,312,314,
                     316..317,319,330,333,349..352)
                     /site_type="active"
                     /db_xref="CDD:271101"
     Site            order(171..175,179,192,194,249,267..270,274,312,314,
                     316..317,319,330)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271101"
     Site            order(175,274,276,312,314,316,333,349..352)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:271101"
     Site            329..352
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:271101"
     CDS             1..556
                     /gene="CAMKK2"
                     /gene_synonym="CAMKK; CAMKKB"
                     /coded_by="XM_054370797.1:132..1802"
                     /db_xref="GeneID:10645"
                     /db_xref="HGNC:HGNC:1470"
                     /db_xref="MIM:615002"
ORIGIN      
        1 msscvssqps snraapqdel ggrgsssses qkpcealrgl sslsihlgme sfivvtecep
       61 gcavdlglar drpleadgqe vpldtsgsqa rphlsgrkls lqersqggla aggsldmngr
      121 cicpslpysp vsspqssprl prrptveshh vsitgmqdcv qlnqytlkde igkgsygvvk
      181 laynendnty yamkvlskkk lirqagfprr ppprgtrpap ggciqprgpi eqvyqeiail
      241 kkldhpnvvk lvevlddpne dhlymvfelv nqgpvmevpt lkplsedqar fyfqdlikgi
      301 eylhyqkiih rdikpsnllv gedghikiad fgvsnefkgs dallsntvgt pafmapesls
      361 etrkifsgka ldvwamgvtl ycfvfgqcpf mderimclhs kiksqalefp dqpdiaedlk
      421 dlitrmldkn pesrivvpei klhpwvtrhg aeplpseden ctlvevteee vensvkhips
      481 latvilvktm irkrsfgnpf egsrreersl sapgnlltkk ptreceslse lkgtkkkkgl
      541 dsmtstvaag wldrrv
//
LOCUS       XP_054226773             556 aa            linear   PRI 05-AUG-2025
DEFINITION  calcium/calmodulin-dependent protein kinase kinase 2 isoform X2
            [Homo sapiens].
ACCESSION   XP_054226773
VERSION     XP_054226773.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370798.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..556
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..556
                     /product="calcium/calmodulin-dependent protein kinase
                     kinase 2 isoform X2"
                     /calculated_mol_wt=61255
     Region          162..447
                     /region_name="STKc_CaMKK2"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calmodulin Dependent Protein Kinase Kinase 2; cd14199"
                     /db_xref="CDD:271101"
     Site            order(171..175,179,192,194,249,267..270,274,276,312,314,
                     316..317,319,330,333,349..352)
                     /site_type="active"
                     /db_xref="CDD:271101"
     Site            order(171..175,179,192,194,249,267..270,274,312,314,
                     316..317,319,330)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271101"
     Site            order(175,274,276,312,314,316,333,349..352)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:271101"
     Site            329..352
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:271101"
     CDS             1..556
                     /gene="CAMKK2"
                     /gene_synonym="CAMKK; CAMKKB"
                     /coded_by="XM_054370798.1:255..1925"
                     /db_xref="GeneID:10645"
                     /db_xref="HGNC:HGNC:1470"
                     /db_xref="MIM:615002"
ORIGIN      
        1 msscvssqps snraapqdel ggrgsssses qkpcealrgl sslsihlgme sfivvtecep
       61 gcavdlglar drpleadgqe vpldtsgsqa rphlsgrkls lqersqggla aggsldmngr
      121 cicpslpysp vsspqssprl prrptveshh vsitgmqdcv qlnqytlkde igkgsygvvk
      181 laynendnty yamkvlskkk lirqagfprr ppprgtrpap ggciqprgpi eqvyqeiail
      241 kkldhpnvvk lvevlddpne dhlymvfelv nqgpvmevpt lkplsedqar fyfqdlikgi
      301 eylhyqkiih rdikpsnllv gedghikiad fgvsnefkgs dallsntvgt pafmapesls
      361 etrkifsgka ldvwamgvtl ycfvfgqcpf mderimclhs kiksqalefp dqpdiaedlk
      421 dlitrmldkn pesrivvpei klhpwvtrhg aeplpseden ctlvevteee vensvkhips
      481 latvilvktm irkrsfgnpf egsrreersl sapgnlltkk ptreceslse lkgtkkkkgl
      541 dsmtstvaag wldrrv
//
LOCUS       XP_054226774             556 aa            linear   PRI 05-AUG-2025
DEFINITION  calcium/calmodulin-dependent protein kinase kinase 2 isoform X2
            [Homo sapiens].
ACCESSION   XP_054226774
VERSION     XP_054226774.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370799.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 1% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..556
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..556
                     /product="calcium/calmodulin-dependent protein kinase
                     kinase 2 isoform X2"
                     /calculated_mol_wt=61255
     Region          162..447
                     /region_name="STKc_CaMKK2"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calmodulin Dependent Protein Kinase Kinase 2; cd14199"
                     /db_xref="CDD:271101"
     Site            order(171..175,179,192,194,249,267..270,274,276,312,314,
                     316..317,319,330,333,349..352)
                     /site_type="active"
                     /db_xref="CDD:271101"
     Site            order(171..175,179,192,194,249,267..270,274,312,314,
                     316..317,319,330)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271101"
     Site            order(175,274,276,312,314,316,333,349..352)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:271101"
     Site            329..352
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:271101"
     CDS             1..556
                     /gene="CAMKK2"
                     /gene_synonym="CAMKK; CAMKKB"
                     /coded_by="XM_054370799.1:341..2011"
                     /db_xref="GeneID:10645"
                     /db_xref="HGNC:HGNC:1470"
                     /db_xref="MIM:615002"
ORIGIN      
        1 msscvssqps snraapqdel ggrgsssses qkpcealrgl sslsihlgme sfivvtecep
       61 gcavdlglar drpleadgqe vpldtsgsqa rphlsgrkls lqersqggla aggsldmngr
      121 cicpslpysp vsspqssprl prrptveshh vsitgmqdcv qlnqytlkde igkgsygvvk
      181 laynendnty yamkvlskkk lirqagfprr ppprgtrpap ggciqprgpi eqvyqeiail
      241 kkldhpnvvk lvevlddpne dhlymvfelv nqgpvmevpt lkplsedqar fyfqdlikgi
      301 eylhyqkiih rdikpsnllv gedghikiad fgvsnefkgs dallsntvgt pafmapesls
      361 etrkifsgka ldvwamgvtl ycfvfgqcpf mderimclhs kiksqalefp dqpdiaedlk
      421 dlitrmldkn pesrivvpei klhpwvtrhg aeplpseden ctlvevteee vensvkhips
      481 latvilvktm irkrsfgnpf egsrreersl sapgnlltkk ptreceslse lkgtkkkkgl
      541 dsmtstvaag wldrrv
//
LOCUS       XP_054226775             545 aa            linear   PRI 05-AUG-2025
DEFINITION  calcium/calmodulin-dependent protein kinase kinase 2 isoform X3
            [Homo sapiens].
ACCESSION   XP_054226775
VERSION     XP_054226775.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370800.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..545
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..545
                     /product="calcium/calmodulin-dependent protein kinase
                     kinase 2 isoform X3"
                     /calculated_mol_wt=59840
     Region          162..442
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Site            order(171..174,177,179,192,194,249,267..270,312,316..317,
                     319,329..330)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271101"
     CDS             1..545
                     /gene="CAMKK2"
                     /gene_synonym="CAMKK; CAMKKB"
                     /coded_by="XM_054370800.1:132..1769"
                     /db_xref="GeneID:10645"
                     /db_xref="HGNC:HGNC:1470"
                     /db_xref="MIM:615002"
ORIGIN      
        1 msscvssqps snraapqdel ggrgsssses qkpcealrgl sslsihlgme sfivvtecep
       61 gcavdlglar drpleadgqe vpldtsgsqa rphlsgrkls lqersqggla aggsldmngr
      121 cicpslpysp vsspqssprl prrptveshh vsitgmqdcv qlnqytlkde igkgsygvvk
      181 laynendnty yamkvlskkk lirqagfprr ppprgtrpap ggciqprgpi eqvyqeiail
      241 kkldhpnvvk lvevlddpne dhlymvfelv nqgpvmevpt lkplsedqar fyfqdlikgi
      301 eylhyqkiih rdikpsnllv gedghikiad fgvsnefkgs dallsntvgt pafmapesls
      361 etrkifsgka ldvwamgvtl ycfvfgqcpf mderimclhs kiksqalefp dqpdiaedlk
      421 dlitrmldkn pesrivvpei kilvktmirk rsfgnpfegs rreerslsap gnlltkkptr
      481 eceslselke arqrrqppgh rpaprggggs alvrgspcve scwapapgsp armhplrpee
      541 amepe
//
LOCUS       XP_054226776             541 aa            linear   PRI 05-AUG-2025
DEFINITION  calcium/calmodulin-dependent protein kinase kinase 2 isoform X4
            [Homo sapiens].
ACCESSION   XP_054226776
VERSION     XP_054226776.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370801.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..541
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..541
                     /product="calcium/calmodulin-dependent protein kinase
                     kinase 2 isoform X4"
                     /calculated_mol_wt=59471
     Region          162..447
                     /region_name="STKc_CaMKK2"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calmodulin Dependent Protein Kinase Kinase 2; cd14199"
                     /db_xref="CDD:271101"
     Site            order(171..175,179,192,194,249,267..270,274,276,312,314,
                     316..317,319,330,333,349..352)
                     /site_type="active"
                     /db_xref="CDD:271101"
     Site            order(171..175,179,192,194,249,267..270,274,312,314,
                     316..317,319,330)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271101"
     Site            order(175,274,276,312,314,316,333,349..352)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:271101"
     Site            329..352
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:271101"
     CDS             1..541
                     /gene="CAMKK2"
                     /gene_synonym="CAMKK; CAMKKB"
                     /coded_by="XM_054370801.1:255..1880"
                     /db_xref="GeneID:10645"
                     /db_xref="HGNC:HGNC:1470"
                     /db_xref="MIM:615002"
ORIGIN      
        1 msscvssqps snraapqdel ggrgsssses qkpcealrgl sslsihlgme sfivvtecep
       61 gcavdlglar drpleadgqe vpldtsgsqa rphlsgrkls lqersqggla aggsldmngr
      121 cicpslpysp vsspqssprl prrptveshh vsitgmqdcv qlnqytlkde igkgsygvvk
      181 laynendnty yamkvlskkk lirqagfprr ppprgtrpap ggciqprgpi eqvyqeiail
      241 kkldhpnvvk lvevlddpne dhlymvfelv nqgpvmevpt lkplsedqar fyfqdlikgi
      301 eylhyqkiih rdikpsnllv gedghikiad fgvsnefkgs dallsntvgt pafmapesls
      361 etrkifsgka ldvwamgvtl ycfvfgqcpf mderimclhs kiksqalefp dqpdiaedlk
      421 dlitrmldkn pesrivvpei klhpwvtrhg aeplpseden ctlvevteee vensvkhips
      481 latvilvktm irkrsfgnpf egsrreersl sapgnlltkq gsednlqgtd pppvgeeevl
      541 l
//
LOCUS       XP_054226777             533 aa            linear   PRI 05-AUG-2025
DEFINITION  calcium/calmodulin-dependent protein kinase kinase 2 isoform X5
            [Homo sapiens].
ACCESSION   XP_054226777
VERSION     XP_054226777.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370802.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..533
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..533
                     /product="calcium/calmodulin-dependent protein kinase
                     kinase 2 isoform X5"
                     /calculated_mol_wt=58768
     Region          162..447
                     /region_name="STKc_CaMKK2"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calmodulin Dependent Protein Kinase Kinase 2; cd14199"
                     /db_xref="CDD:271101"
     Site            order(171..175,179,192,194,249,267..270,274,276,312,314,
                     316..317,319,330,333,349..352)
                     /site_type="active"
                     /db_xref="CDD:271101"
     Site            order(171..175,179,192,194,249,267..270,274,312,314,
                     316..317,319,330)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271101"
     Site            order(175,274,276,312,314,316,333,349..352)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:271101"
     Site            329..352
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:271101"
     CDS             1..533
                     /gene="CAMKK2"
                     /gene_synonym="CAMKK; CAMKKB"
                     /coded_by="XM_054370802.1:132..1733"
                     /db_xref="GeneID:10645"
                     /db_xref="HGNC:HGNC:1470"
                     /db_xref="MIM:615002"
ORIGIN      
        1 msscvssqps snraapqdel ggrgsssses qkpcealrgl sslsihlgme sfivvtecep
       61 gcavdlglar drpleadgqe vpldtsgsqa rphlsgrkls lqersqggla aggsldmngr
      121 cicpslpysp vsspqssprl prrptveshh vsitgmqdcv qlnqytlkde igkgsygvvk
      181 laynendnty yamkvlskkk lirqagfprr ppprgtrpap ggciqprgpi eqvyqeiail
      241 kkldhpnvvk lvevlddpne dhlymvfelv nqgpvmevpt lkplsedqar fyfqdlikgi
      301 eylhyqkiih rdikpsnllv gedghikiad fgvsnefkgs dallsntvgt pafmapesls
      361 etrkifsgka ldvwamgvtl ycfvfgqcpf mderimclhs kiksqalefp dqpdiaedlk
      421 dlitrmldkn pesrivvpei klhpwvtrhg aeplpseden ctlvevteee vensvkhips
      481 latvilvktm irkrsfgnpf egsrreersl sapgnlltkk ptreceslse lkt
//
LOCUS       XP_054226778             533 aa            linear   PRI 05-AUG-2025
DEFINITION  calcium/calmodulin-dependent protein kinase kinase 2 isoform X5
            [Homo sapiens].
ACCESSION   XP_054226778
VERSION     XP_054226778.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370803.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..533
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..533
                     /product="calcium/calmodulin-dependent protein kinase
                     kinase 2 isoform X5"
                     /calculated_mol_wt=58768
     Region          162..447
                     /region_name="STKc_CaMKK2"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Calmodulin Dependent Protein Kinase Kinase 2; cd14199"
                     /db_xref="CDD:271101"
     Site            order(171..175,179,192,194,249,267..270,274,276,312,314,
                     316..317,319,330,333,349..352)
                     /site_type="active"
                     /db_xref="CDD:271101"
     Site            order(171..175,179,192,194,249,267..270,274,312,314,
                     316..317,319,330)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271101"
     Site            order(175,274,276,312,314,316,333,349..352)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:271101"
     Site            329..352
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:271101"
     CDS             1..533
                     /gene="CAMKK2"
                     /gene_synonym="CAMKK; CAMKKB"
                     /coded_by="XM_054370803.1:255..1856"
                     /db_xref="GeneID:10645"
                     /db_xref="HGNC:HGNC:1470"
                     /db_xref="MIM:615002"
ORIGIN      
        1 msscvssqps snraapqdel ggrgsssses qkpcealrgl sslsihlgme sfivvtecep
       61 gcavdlglar drpleadgqe vpldtsgsqa rphlsgrkls lqersqggla aggsldmngr
      121 cicpslpysp vsspqssprl prrptveshh vsitgmqdcv qlnqytlkde igkgsygvvk
      181 laynendnty yamkvlskkk lirqagfprr ppprgtrpap ggciqprgpi eqvyqeiail
      241 kkldhpnvvk lvevlddpne dhlymvfelv nqgpvmevpt lkplsedqar fyfqdlikgi
      301 eylhyqkiih rdikpsnllv gedghikiad fgvsnefkgs dallsntvgt pafmapesls
      361 etrkifsgka ldvwamgvtl ycfvfgqcpf mderimclhs kiksqalefp dqpdiaedlk
      421 dlitrmldkn pesrivvpei klhpwvtrhg aeplpseden ctlvevteee vensvkhips
      481 latvilvktm irkrsfgnpf egsrreersl sapgnlltkk ptreceslse lkt
//
LOCUS       XP_054226779             513 aa            linear   PRI 05-AUG-2025
DEFINITION  calcium/calmodulin-dependent protein kinase kinase 2 isoform X6
            [Homo sapiens].
ACCESSION   XP_054226779
VERSION     XP_054226779.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370804.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..513
                     /product="calcium/calmodulin-dependent protein kinase
                     kinase 2 isoform X6"
                     /calculated_mol_wt=56480
     Region          162..442
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Site            order(171..174,177,179,192,194,249,267..270,312,316..317,
                     319,329..330)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271101"
     CDS             1..513
                     /gene="CAMKK2"
                     /gene_synonym="CAMKK; CAMKKB"
                     /coded_by="XM_054370804.1:132..1673"
                     /db_xref="GeneID:10645"
                     /db_xref="HGNC:HGNC:1470"
                     /db_xref="MIM:615002"
ORIGIN      
        1 msscvssqps snraapqdel ggrgsssses qkpcealrgl sslsihlgme sfivvtecep
       61 gcavdlglar drpleadgqe vpldtsgsqa rphlsgrkls lqersqggla aggsldmngr
      121 cicpslpysp vsspqssprl prrptveshh vsitgmqdcv qlnqytlkde igkgsygvvk
      181 laynendnty yamkvlskkk lirqagfprr ppprgtrpap ggciqprgpi eqvyqeiail
      241 kkldhpnvvk lvevlddpne dhlymvfelv nqgpvmevpt lkplsedqar fyfqdlikgi
      301 eylhyqkiih rdikpsnllv gedghikiad fgvsnefkgs dallsntvgt pafmapesls
      361 etrkifsgka ldvwamgvtl ycfvfgqcpf mderimclhs kiksqalefp dqpdiaedlk
      421 dlitrmldkn pesrivvpei kilvktmirk rsfgnpfegs rreerslsap gnlltkkptr
      481 eceslselkg tkkkkgldsm tstvaagwld rrv
//
LOCUS       XP_054226780             500 aa            linear   PRI 05-AUG-2025
DEFINITION  calcium/calmodulin-dependent protein kinase kinase 2 isoform X7
            [Homo sapiens].
ACCESSION   XP_054226780
VERSION     XP_054226780.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370805.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..500
                     /product="calcium/calmodulin-dependent protein kinase
                     kinase 2 isoform X7"
                     /calculated_mol_wt=54475
     Region          162..442
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Site            order(171..174,177,179,192,194,249,267..270,312,316..317,
                     319,329..330)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271101"
     CDS             1..500
                     /gene="CAMKK2"
                     /gene_synonym="CAMKK; CAMKKB"
                     /coded_by="XM_054370805.1:132..1634"
                     /db_xref="GeneID:10645"
                     /db_xref="HGNC:HGNC:1470"
                     /db_xref="MIM:615002"
ORIGIN      
        1 msscvssqps snraapqdel ggrgsssses qkpcealrgl sslsihlgme sfivvtecep
       61 gcavdlglar drpleadgqe vpldtsgsqa rphlsgrkls lqersqggla aggsldmngr
      121 cicpslpysp vsspqssprl prrptveshh vsitgmqdcv qlnqytlkde igkgsygvvk
      181 laynendnty yamkvlskkk lirqagfprr ppprgtrpap ggciqprgpi eqvyqeiail
      241 kkldhpnvvk lvevlddpne dhlymvfelv nqgpvmevpt lkplsedqar fyfqdlikgi
      301 eylhyqkiih rdikpsnllv gedghikiad fgvsnefkgs dallsntvgt pafmapesls
      361 etrkifsgka ldvwamgvtl ycfvfgqcpf mderimclhs kiksqalefp dqpdiaedlk
      421 dlitrmldkn pesrivvpei klfcmpdhrp lplrpacpcg sarwqgppva shtcpsplls
      481 fveaaplghe awggavavgg
//
LOCUS       XP_054226781             498 aa            linear   PRI 05-AUG-2025
DEFINITION  calcium/calmodulin-dependent protein kinase kinase 2 isoform X8
            [Homo sapiens].
ACCESSION   XP_054226781
VERSION     XP_054226781.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370806.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..498
                     /product="calcium/calmodulin-dependent protein kinase
                     kinase 2 isoform X8"
                     /calculated_mol_wt=54696
     Region          162..442
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Site            order(171..174,177,179,192,194,249,267..270,312,316..317,
                     319,329..330)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271101"
     CDS             1..498
                     /gene="CAMKK2"
                     /gene_synonym="CAMKK; CAMKKB"
                     /coded_by="XM_054370806.1:132..1628"
                     /db_xref="GeneID:10645"
                     /db_xref="HGNC:HGNC:1470"
                     /db_xref="MIM:615002"
ORIGIN      
        1 msscvssqps snraapqdel ggrgsssses qkpcealrgl sslsihlgme sfivvtecep
       61 gcavdlglar drpleadgqe vpldtsgsqa rphlsgrkls lqersqggla aggsldmngr
      121 cicpslpysp vsspqssprl prrptveshh vsitgmqdcv qlnqytlkde igkgsygvvk
      181 laynendnty yamkvlskkk lirqagfprr ppprgtrpap ggciqprgpi eqvyqeiail
      241 kkldhpnvvk lvevlddpne dhlymvfelv nqgpvmevpt lkplsedqar fyfqdlikgi
      301 eylhyqkiih rdikpsnllv gedghikiad fgvsnefkgs dallsntvgt pafmapesls
      361 etrkifsgka ldvwamgvtl ycfvfgqcpf mderimclhs kiksqalefp dqpdiaedlk
      421 dlitrmldkn pesrivvpei kilvktmirk rsfgnpfegs rreerslsap gnlltkqgse
      481 dnlqgtdppp vgeeevll
//
LOCUS       XP_054226782             498 aa            linear   PRI 05-AUG-2025
DEFINITION  calcium/calmodulin-dependent protein kinase kinase 2 isoform X8
            [Homo sapiens].
ACCESSION   XP_054226782
VERSION     XP_054226782.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370807.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..498
                     /product="calcium/calmodulin-dependent protein kinase
                     kinase 2 isoform X8"
                     /calculated_mol_wt=54696
     Region          162..442
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Site            order(171..174,177,179,192,194,249,267..270,312,316..317,
                     319,329..330)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271101"
     CDS             1..498
                     /gene="CAMKK2"
                     /gene_synonym="CAMKK; CAMKKB"
                     /coded_by="XM_054370807.1:255..1751"
                     /db_xref="GeneID:10645"
                     /db_xref="HGNC:HGNC:1470"
                     /db_xref="MIM:615002"
ORIGIN      
        1 msscvssqps snraapqdel ggrgsssses qkpcealrgl sslsihlgme sfivvtecep
       61 gcavdlglar drpleadgqe vpldtsgsqa rphlsgrkls lqersqggla aggsldmngr
      121 cicpslpysp vsspqssprl prrptveshh vsitgmqdcv qlnqytlkde igkgsygvvk
      181 laynendnty yamkvlskkk lirqagfprr ppprgtrpap ggciqprgpi eqvyqeiail
      241 kkldhpnvvk lvevlddpne dhlymvfelv nqgpvmevpt lkplsedqar fyfqdlikgi
      301 eylhyqkiih rdikpsnllv gedghikiad fgvsnefkgs dallsntvgt pafmapesls
      361 etrkifsgka ldvwamgvtl ycfvfgqcpf mderimclhs kiksqalefp dqpdiaedlk
      421 dlitrmldkn pesrivvpei kilvktmirk rsfgnpfegs rreerslsap gnlltkqgse
      481 dnlqgtdppp vgeeevll
//
LOCUS       XP_054226783             490 aa            linear   PRI 05-AUG-2025
DEFINITION  calcium/calmodulin-dependent protein kinase kinase 2 isoform X9
            [Homo sapiens].
ACCESSION   XP_054226783
VERSION     XP_054226783.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370808.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..490
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..490
                     /product="calcium/calmodulin-dependent protein kinase
                     kinase 2 isoform X9"
                     /calculated_mol_wt=53993
     Region          162..442
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Site            order(171..174,177,179,192,194,249,267..270,312,316..317,
                     319,329..330)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270870"
     CDS             1..490
                     /gene="CAMKK2"
                     /gene_synonym="CAMKK; CAMKKB"
                     /coded_by="XM_054370808.1:132..1604"
                     /db_xref="GeneID:10645"
                     /db_xref="HGNC:HGNC:1470"
                     /db_xref="MIM:615002"
ORIGIN      
        1 msscvssqps snraapqdel ggrgsssses qkpcealrgl sslsihlgme sfivvtecep
       61 gcavdlglar drpleadgqe vpldtsgsqa rphlsgrkls lqersqggla aggsldmngr
      121 cicpslpysp vsspqssprl prrptveshh vsitgmqdcv qlnqytlkde igkgsygvvk
      181 laynendnty yamkvlskkk lirqagfprr ppprgtrpap ggciqprgpi eqvyqeiail
      241 kkldhpnvvk lvevlddpne dhlymvfelv nqgpvmevpt lkplsedqar fyfqdlikgi
      301 eylhyqkiih rdikpsnllv gedghikiad fgvsnefkgs dallsntvgt pafmapesls
      361 etrkifsgka ldvwamgvtl ycfvfgqcpf mderimclhs kiksqalefp dqpdiaedlk
      421 dlitrmldkn pesrivvpei kilvktmirk rsfgnpfegs rreerslsap gnlltkkptr
      481 eceslselkt
//
LOCUS       XP_054226784             424 aa            linear   PRI 05-AUG-2025
DEFINITION  calcium/calmodulin-dependent protein kinase kinase 2 isoform X10
            [Homo sapiens].
ACCESSION   XP_054226784
VERSION     XP_054226784.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370809.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 38% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..424
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..424
                     /product="calcium/calmodulin-dependent protein kinase
                     kinase 2 isoform X10"
                     /calculated_mol_wt=47420
     Region          9..283
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     Site            order(9..10,13,15,28,30,85,103..106,148,152..153,155,
                     165..166)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271101"
     CDS             1..424
                     /gene="CAMKK2"
                     /gene_synonym="CAMKK; CAMKKB"
                     /coded_by="XM_054370809.1:598..1872"
                     /db_xref="GeneID:10645"
                     /db_xref="HGNC:HGNC:1470"
                     /db_xref="MIM:615002"
ORIGIN      
        1 mswaspfiqg sygvvklayn endntyyamk vlskkklirq agfprrpppr gtrpapggci
       61 qprgpieqvy qeiailkkld hpnvvklvev lddpnedhly mvfelvnqgp vmevptlkpl
      121 sedqarfyfq dlikgieylh yqkiihrdik psnllvgedg hikiadfgvs nefkgsdall
      181 sntvgtpafm apeslsetrk ifsgkaldvw amgvtlycfv fgqcpfmder imclhskiks
      241 qalefpdqpd iaedlkdlit rmldknpesr ivvpeiklhp wvtrhgaepl psedenctlv
      301 evteeevens vkhipslatv ilvktmirkr sfgnpfegsr reerslsapg nlltkkptre
      361 ceslselkea rqrrqppghr paprggggsa lvrgspcves cwapapgspa rmhplrpeea
      421 mepe
//
LOCUS       XP_054226785             313 aa            linear   PRI 05-AUG-2025
DEFINITION  calcium/calmodulin-dependent protein kinase kinase 2 isoform X11
            [Homo sapiens].
ACCESSION   XP_054226785
VERSION     XP_054226785.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370810.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..313
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..313
                     /product="calcium/calmodulin-dependent protein kinase
                     kinase 2 isoform X11"
                     /calculated_mol_wt=34889
     Region          <1..172
                     /region_name="Protein Kinases, catalytic domain"
                     /note="The protein kinase superfamily is mainly composed
                     of the catalytic domains of serine/threonine-specific and
                     tyrosine-specific protein kinases. It also includes RIO
                     kinases, which are atypical serine protein kinases,
                     aminoglycoside phosphotransferases; cl21453"
                     /db_xref="CDD:473864"
     CDS             1..313
                     /gene="CAMKK2"
                     /gene_synonym="CAMKK; CAMKKB"
                     /coded_by="XM_054370810.1:76..1017"
                     /db_xref="GeneID:10645"
                     /db_xref="HGNC:HGNC:1470"
                     /db_xref="MIM:615002"
ORIGIN      
        1 mevptlkpls edqarfyfqd likgieylhy qkiihrdikp snllvgedgh ikiadfgvsn
       61 efkgsdalls ntvgtpafma peslsetrki fsgkaldvwa mgvtlycfvf gqcpfmderi
      121 mclhskiksq alefpdqpdi aedlkdlitr mldknpesri vvpeiklhpw vtrhgaeplp
      181 sedenctlve vteeevensv khipslatvi lvktmirkrs fgnpfegsrr eerslsapgn
      241 lltkkptrec eslselkear qrrqppghrp aprggggsal vrgspcvesc wapapgspar
      301 mhplrpeeam epe
//
LOCUS       XP_054226786             863 aa            linear   PRI 05-AUG-2025
DEFINITION  advillin isoform X1 [Homo sapiens].
ACCESSION   XP_054226786
VERSION     XP_054226786.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370811.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..863
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..863
                     /product="advillin isoform X1"
                     /calculated_mol_wt=96551
     Region          7..118
                     /region_name="gelsolin_S1_like"
                     /note="Gelsolin sub-domain 1-like domain found in
                     gelsolin, severin, villin, and related proteins; cd11290"
                     /db_xref="CDD:200446"
     Site            order(24..25,63,69..70,72..74,76..78,80..81,92,94)
                     /site_type="other"
                     /note="putative actin binding interface [polypeptide
                     binding]"
                     /db_xref="CDD:200446"
     Region          133..223
                     /region_name="gelsolin_S2_like"
                     /note="Gelsolin sub-domain 2-like domain found in
                     gelsolin, severin, villin, and related proteins; cd11289"
                     /db_xref="CDD:200445"
     Region          247..345
                     /region_name="gelsolin_S3_like"
                     /note="Gelsolin sub-domain 3-like domain found in
                     gelsolin, severin, villin, and related proteins; cd11292"
                     /db_xref="CDD:200448"
     Site            order(340,345)
                     /site_type="other"
                     /note="putative nucleotide binding site [chemical
                     binding]"
                     /db_xref="CDD:200448"
     Region          389..489
                     /region_name="gelsolin_S4_like"
                     /note="Gelsolin sub-domain 4-like domain found in
                     gelsolin, severin, villin, and related proteins; cd11293"
                     /db_xref="CDD:200449"
     Site            order(405..406,444,450..451,453..455,457..459,461..462,
                     473,475)
                     /site_type="other"
                     /note="putative actin binding interface [polypeptide
                     binding]"
                     /db_xref="CDD:200449"
     Site            480
                     /site_type="other"
                     /note="putative nucleotide binding residue [chemical
                     binding]"
                     /db_xref="CDD:200449"
     Region          510..600
                     /region_name="gelsolin_S5_like"
                     /note="Gelsolin sub-domain 5-like domain found in
                     gelsolin, severin, villin, and related proteins; cd11288"
                     /db_xref="CDD:200444"
     Site            518
                     /site_type="other"
                     /note="putative nucleotide binding residue [chemical
                     binding]"
                     /db_xref="CDD:200444"
     Region          659..756
                     /region_name="gelsolin_S6_like"
                     /note="Gelsolin sub-domain 6-like domain found in
                     gelsolin, severin, villin, and related proteins; cd11291"
                     /db_xref="CDD:200447"
     Region          828..863
                     /region_name="VHP"
                     /note="Villin headpiece domain; pfam02209"
                     /db_xref="CDD:460493"
     CDS             1..863
                     /gene="AVIL"
                     /gene_synonym="ADVIL; DOC6; NPHS21; p92"
                     /coded_by="XM_054370811.1:126..2717"
                     /db_xref="GeneID:10677"
                     /db_xref="HGNC:HGNC:14188"
                     /db_xref="MIM:613397"
ORIGIN      
        1 mpltsafrav dndpgiivwr iekmelalvp vsahgnfyeg dcyvilstrr vasllsqdih
       61 fwigkdssqd eqscaaiytt qlddylggsp vqhrevqyhe sdtfrgyfkq giiykqggva
      121 sgmkhvetnt ydvkrllhvk gkrniratev emswdsfnrg dvflldlgkv iiqwngpesn
      181 sgerlkamll akdirdrerg graeigvieg dkeaaspelm kvlqdtlgrr siikptvpde
      241 iidqkqksti mlyhisdsag qlavtevatr plvqdllnhd dcyildqsgt kiyvwkgkga
      301 tkaekqaams kalgfikmks ypsstnvetv ndgaesamfk qlfqkwsvkd qtmglgktfs
      361 igkiakvfqd kfdvtllhtk pevaaqermv ddgngkvevw rienlelvpv eyqwygffyg
      421 gdcylvlyty evngkphhil yiwqgrhasq delaasayqa vevdrqfdga avqvrvrmgt
      481 eprhfmaifk gklvifeggt srkgnaepdp pvrlfqihgn dksntkavev pafasslnsn
      541 dvfllrtqae hylwygkgss gderamakel asllcdgsen tvaegqepae fwdllggktp
      601 yandkrygnt aspssglplp arlvnctkak tsvlktflss lmplnglycr lqqeildvqs
      661 rlfecsnktg qfvvteitdf tqddlnptdv mlldtwdqvf lwigaeanat ekesalataq
      721 qylhthpsgr dpdtpiliik qgfeppiftg wflawdpniw sagktyeqlk eelgdaaaim
      781 ritadmknat lslnsndsep kyypiavllk nqnqelpedv npakkenyls eqdfvsvfgi
      841 trgqfaalpg wkqlqmkkek glf
//
LOCUS       XP_054226787             840 aa            linear   PRI 05-AUG-2025
DEFINITION  advillin isoform X2 [Homo sapiens].
ACCESSION   XP_054226787
VERSION     XP_054226787.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370812.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..840
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..840
                     /product="advillin isoform X2"
                     /calculated_mol_wt=93940
     Region          1..95
                     /region_name="gelsolin_S1_like"
                     /note="Gelsolin sub-domain 1-like domain found in
                     gelsolin, severin, villin, and related proteins; cd11290"
                     /db_xref="CDD:200446"
     Site            order(1..2,40,46..47,49..51,53..55,57..58,69,71)
                     /site_type="other"
                     /note="putative actin binding interface [polypeptide
                     binding]"
                     /db_xref="CDD:200446"
     Region          110..200
                     /region_name="gelsolin_S2_like"
                     /note="Gelsolin sub-domain 2-like domain found in
                     gelsolin, severin, villin, and related proteins; cd11289"
                     /db_xref="CDD:200445"
     Region          224..322
                     /region_name="gelsolin_S3_like"
                     /note="Gelsolin sub-domain 3-like domain found in
                     gelsolin, severin, villin, and related proteins; cd11292"
                     /db_xref="CDD:200448"
     Site            order(317,322)
                     /site_type="other"
                     /note="putative nucleotide binding site [chemical
                     binding]"
                     /db_xref="CDD:200448"
     Region          366..466
                     /region_name="gelsolin_S4_like"
                     /note="Gelsolin sub-domain 4-like domain found in
                     gelsolin, severin, villin, and related proteins; cd11293"
                     /db_xref="CDD:200449"
     Site            order(382..383,421,427..428,430..432,434..436,438..439,
                     450,452)
                     /site_type="other"
                     /note="putative actin binding interface [polypeptide
                     binding]"
                     /db_xref="CDD:200449"
     Site            457
                     /site_type="other"
                     /note="putative nucleotide binding residue [chemical
                     binding]"
                     /db_xref="CDD:200449"
     Region          487..577
                     /region_name="gelsolin_S5_like"
                     /note="Gelsolin sub-domain 5-like domain found in
                     gelsolin, severin, villin, and related proteins; cd11288"
                     /db_xref="CDD:200444"
     Site            495
                     /site_type="other"
                     /note="putative nucleotide binding residue [chemical
                     binding]"
                     /db_xref="CDD:200444"
     Region          636..733
                     /region_name="gelsolin_S6_like"
                     /note="Gelsolin sub-domain 6-like domain found in
                     gelsolin, severin, villin, and related proteins; cd11291"
                     /db_xref="CDD:200447"
     Region          805..840
                     /region_name="VHP"
                     /note="Villin headpiece domain; pfam02209"
                     /db_xref="CDD:460493"
     CDS             1..840
                     /gene="AVIL"
                     /gene_synonym="ADVIL; DOC6; NPHS21; p92"
                     /coded_by="XM_054370812.1:4410..6932"
                     /db_xref="GeneID:10677"
                     /db_xref="HGNC:HGNC:14188"
                     /db_xref="MIM:613397"
ORIGIN      
        1 melalvpvsa hgnfyegdcy vilstrrvas llsqdihfwi gkdssqdeqs caaiyttqld
       61 dylggspvqh revqyhesdt frgyfkqgii ykqggvasgm khvetntydv krllhvkgkr
      121 niratevems wdsfnrgdvf lldlgkviiq wngpesnsge rlkamllakd irdrerggra
      181 eigviegdke aaspelmkvl qdtlgrrsii kptvpdeiid qkqkstimly hisdsagqla
      241 vtevatrplv qdllnhddcy ildqsgtkiy vwkgkgatka ekqaamskal gfikmksyps
      301 stnvetvndg aesamfkqlf qkwsvkdqtm glgktfsigk iakvfqdkfd vtllhtkpev
      361 aaqermvddg ngkvevwrie nlelvpveyq wygffyggdc ylvlytyevn gkphhilyiw
      421 qgrhasqdel aasayqavev drqfdgaavq vrvrmgtepr hfmaifkgkl vifeggtsrk
      481 gnaepdppvr lfqihgndks ntkavevpaf asslnsndvf llrtqaehyl wygkgssgde
      541 ramakelasl lcdgsentva egqepaefwd llggktpyan dkrygntasp ssglplparl
      601 vnctkaktsv lktflsslmp lnglycrlqq eildvqsrlf ecsnktgqfv vteitdftqd
      661 dlnptdvmll dtwdqvflwi gaeanateke salataqqyl hthpsgrdpd tpiliikqgf
      721 eppiftgwfl awdpniwsag ktyeqlkeel gdaaaimrit admknatlsl nsndsepkyy
      781 piavllknqn qelpedvnpa kkenylseqd fvsvfgitrg qfaalpgwkq lqmkkekglf
//
LOCUS       XP_054226788             840 aa            linear   PRI 05-AUG-2025
DEFINITION  advillin isoform X2 [Homo sapiens].
ACCESSION   XP_054226788
VERSION     XP_054226788.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370813.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..840
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..840
                     /product="advillin isoform X2"
                     /calculated_mol_wt=93940
     Region          1..95
                     /region_name="gelsolin_S1_like"
                     /note="Gelsolin sub-domain 1-like domain found in
                     gelsolin, severin, villin, and related proteins; cd11290"
                     /db_xref="CDD:200446"
     Site            order(1..2,40,46..47,49..51,53..55,57..58,69,71)
                     /site_type="other"
                     /note="putative actin binding interface [polypeptide
                     binding]"
                     /db_xref="CDD:200446"
     Region          110..200
                     /region_name="gelsolin_S2_like"
                     /note="Gelsolin sub-domain 2-like domain found in
                     gelsolin, severin, villin, and related proteins; cd11289"
                     /db_xref="CDD:200445"
     Region          224..322
                     /region_name="gelsolin_S3_like"
                     /note="Gelsolin sub-domain 3-like domain found in
                     gelsolin, severin, villin, and related proteins; cd11292"
                     /db_xref="CDD:200448"
     Site            order(317,322)
                     /site_type="other"
                     /note="putative nucleotide binding site [chemical
                     binding]"
                     /db_xref="CDD:200448"
     Region          366..466
                     /region_name="gelsolin_S4_like"
                     /note="Gelsolin sub-domain 4-like domain found in
                     gelsolin, severin, villin, and related proteins; cd11293"
                     /db_xref="CDD:200449"
     Site            order(382..383,421,427..428,430..432,434..436,438..439,
                     450,452)
                     /site_type="other"
                     /note="putative actin binding interface [polypeptide
                     binding]"
                     /db_xref="CDD:200449"
     Site            457
                     /site_type="other"
                     /note="putative nucleotide binding residue [chemical
                     binding]"
                     /db_xref="CDD:200449"
     Region          487..577
                     /region_name="gelsolin_S5_like"
                     /note="Gelsolin sub-domain 5-like domain found in
                     gelsolin, severin, villin, and related proteins; cd11288"
                     /db_xref="CDD:200444"
     Site            495
                     /site_type="other"
                     /note="putative nucleotide binding residue [chemical
                     binding]"
                     /db_xref="CDD:200444"
     Region          636..733
                     /region_name="gelsolin_S6_like"
                     /note="Gelsolin sub-domain 6-like domain found in
                     gelsolin, severin, villin, and related proteins; cd11291"
                     /db_xref="CDD:200447"
     Region          805..840
                     /region_name="VHP"
                     /note="Villin headpiece domain; pfam02209"
                     /db_xref="CDD:460493"
     CDS             1..840
                     /gene="AVIL"
                     /gene_synonym="ADVIL; DOC6; NPHS21; p92"
                     /coded_by="XM_054370813.1:4185..6707"
                     /db_xref="GeneID:10677"
                     /db_xref="HGNC:HGNC:14188"
                     /db_xref="MIM:613397"
ORIGIN      
        1 melalvpvsa hgnfyegdcy vilstrrvas llsqdihfwi gkdssqdeqs caaiyttqld
       61 dylggspvqh revqyhesdt frgyfkqgii ykqggvasgm khvetntydv krllhvkgkr
      121 niratevems wdsfnrgdvf lldlgkviiq wngpesnsge rlkamllakd irdrerggra
      181 eigviegdke aaspelmkvl qdtlgrrsii kptvpdeiid qkqkstimly hisdsagqla
      241 vtevatrplv qdllnhddcy ildqsgtkiy vwkgkgatka ekqaamskal gfikmksyps
      301 stnvetvndg aesamfkqlf qkwsvkdqtm glgktfsigk iakvfqdkfd vtllhtkpev
      361 aaqermvddg ngkvevwrie nlelvpveyq wygffyggdc ylvlytyevn gkphhilyiw
      421 qgrhasqdel aasayqavev drqfdgaavq vrvrmgtepr hfmaifkgkl vifeggtsrk
      481 gnaepdppvr lfqihgndks ntkavevpaf asslnsndvf llrtqaehyl wygkgssgde
      541 ramakelasl lcdgsentva egqepaefwd llggktpyan dkrygntasp ssglplparl
      601 vnctkaktsv lktflsslmp lnglycrlqq eildvqsrlf ecsnktgqfv vteitdftqd
      661 dlnptdvmll dtwdqvflwi gaeanateke salataqqyl hthpsgrdpd tpiliikqgf
      721 eppiftgwfl awdpniwsag ktyeqlkeel gdaaaimrit admknatlsl nsndsepkyy
      781 piavllknqn qelpedvnpa kkenylseqd fvsvfgitrg qfaalpgwkq lqmkkekglf
//
LOCUS       XP_054226789             840 aa            linear   PRI 05-AUG-2025
DEFINITION  advillin isoform X2 [Homo sapiens].
ACCESSION   XP_054226789
VERSION     XP_054226789.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370814.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..840
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..840
                     /product="advillin isoform X2"
                     /calculated_mol_wt=93940
     Region          1..95
                     /region_name="gelsolin_S1_like"
                     /note="Gelsolin sub-domain 1-like domain found in
                     gelsolin, severin, villin, and related proteins; cd11290"
                     /db_xref="CDD:200446"
     Site            order(1..2,40,46..47,49..51,53..55,57..58,69,71)
                     /site_type="other"
                     /note="putative actin binding interface [polypeptide
                     binding]"
                     /db_xref="CDD:200446"
     Region          110..200
                     /region_name="gelsolin_S2_like"
                     /note="Gelsolin sub-domain 2-like domain found in
                     gelsolin, severin, villin, and related proteins; cd11289"
                     /db_xref="CDD:200445"
     Region          224..322
                     /region_name="gelsolin_S3_like"
                     /note="Gelsolin sub-domain 3-like domain found in
                     gelsolin, severin, villin, and related proteins; cd11292"
                     /db_xref="CDD:200448"
     Site            order(317,322)
                     /site_type="other"
                     /note="putative nucleotide binding site [chemical
                     binding]"
                     /db_xref="CDD:200448"
     Region          366..466
                     /region_name="gelsolin_S4_like"
                     /note="Gelsolin sub-domain 4-like domain found in
                     gelsolin, severin, villin, and related proteins; cd11293"
                     /db_xref="CDD:200449"
     Site            order(382..383,421,427..428,430..432,434..436,438..439,
                     450,452)
                     /site_type="other"
                     /note="putative actin binding interface [polypeptide
                     binding]"
                     /db_xref="CDD:200449"
     Site            457
                     /site_type="other"
                     /note="putative nucleotide binding residue [chemical
                     binding]"
                     /db_xref="CDD:200449"
     Region          487..577
                     /region_name="gelsolin_S5_like"
                     /note="Gelsolin sub-domain 5-like domain found in
                     gelsolin, severin, villin, and related proteins; cd11288"
                     /db_xref="CDD:200444"
     Site            495
                     /site_type="other"
                     /note="putative nucleotide binding residue [chemical
                     binding]"
                     /db_xref="CDD:200444"
     Region          636..733
                     /region_name="gelsolin_S6_like"
                     /note="Gelsolin sub-domain 6-like domain found in
                     gelsolin, severin, villin, and related proteins; cd11291"
                     /db_xref="CDD:200447"
     Region          805..840
                     /region_name="VHP"
                     /note="Villin headpiece domain; pfam02209"
                     /db_xref="CDD:460493"
     CDS             1..840
                     /gene="AVIL"
                     /gene_synonym="ADVIL; DOC6; NPHS21; p92"
                     /coded_by="XM_054370814.1:4128..6650"
                     /db_xref="GeneID:10677"
                     /db_xref="HGNC:HGNC:14188"
                     /db_xref="MIM:613397"
ORIGIN      
        1 melalvpvsa hgnfyegdcy vilstrrvas llsqdihfwi gkdssqdeqs caaiyttqld
       61 dylggspvqh revqyhesdt frgyfkqgii ykqggvasgm khvetntydv krllhvkgkr
      121 niratevems wdsfnrgdvf lldlgkviiq wngpesnsge rlkamllakd irdrerggra
      181 eigviegdke aaspelmkvl qdtlgrrsii kptvpdeiid qkqkstimly hisdsagqla
      241 vtevatrplv qdllnhddcy ildqsgtkiy vwkgkgatka ekqaamskal gfikmksyps
      301 stnvetvndg aesamfkqlf qkwsvkdqtm glgktfsigk iakvfqdkfd vtllhtkpev
      361 aaqermvddg ngkvevwrie nlelvpveyq wygffyggdc ylvlytyevn gkphhilyiw
      421 qgrhasqdel aasayqavev drqfdgaavq vrvrmgtepr hfmaifkgkl vifeggtsrk
      481 gnaepdppvr lfqihgndks ntkavevpaf asslnsndvf llrtqaehyl wygkgssgde
      541 ramakelasl lcdgsentva egqepaefwd llggktpyan dkrygntasp ssglplparl
      601 vnctkaktsv lktflsslmp lnglycrlqq eildvqsrlf ecsnktgqfv vteitdftqd
      661 dlnptdvmll dtwdqvflwi gaeanateke salataqqyl hthpsgrdpd tpiliikqgf
      721 eppiftgwfl awdpniwsag ktyeqlkeel gdaaaimrit admknatlsl nsndsepkyy
      781 piavllknqn qelpedvnpa kkenylseqd fvsvfgitrg qfaalpgwkq lqmkkekglf
//
LOCUS       XP_054226790             840 aa            linear   PRI 05-AUG-2025
DEFINITION  advillin isoform X2 [Homo sapiens].
ACCESSION   XP_054226790
VERSION     XP_054226790.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370815.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..840
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..840
                     /product="advillin isoform X2"
                     /calculated_mol_wt=93940
     Region          1..95
                     /region_name="gelsolin_S1_like"
                     /note="Gelsolin sub-domain 1-like domain found in
                     gelsolin, severin, villin, and related proteins; cd11290"
                     /db_xref="CDD:200446"
     Site            order(1..2,40,46..47,49..51,53..55,57..58,69,71)
                     /site_type="other"
                     /note="putative actin binding interface [polypeptide
                     binding]"
                     /db_xref="CDD:200446"
     Region          110..200
                     /region_name="gelsolin_S2_like"
                     /note="Gelsolin sub-domain 2-like domain found in
                     gelsolin, severin, villin, and related proteins; cd11289"
                     /db_xref="CDD:200445"
     Region          224..322
                     /region_name="gelsolin_S3_like"
                     /note="Gelsolin sub-domain 3-like domain found in
                     gelsolin, severin, villin, and related proteins; cd11292"
                     /db_xref="CDD:200448"
     Site            order(317,322)
                     /site_type="other"
                     /note="putative nucleotide binding site [chemical
                     binding]"
                     /db_xref="CDD:200448"
     Region          366..466
                     /region_name="gelsolin_S4_like"
                     /note="Gelsolin sub-domain 4-like domain found in
                     gelsolin, severin, villin, and related proteins; cd11293"
                     /db_xref="CDD:200449"
     Site            order(382..383,421,427..428,430..432,434..436,438..439,
                     450,452)
                     /site_type="other"
                     /note="putative actin binding interface [polypeptide
                     binding]"
                     /db_xref="CDD:200449"
     Site            457
                     /site_type="other"
                     /note="putative nucleotide binding residue [chemical
                     binding]"
                     /db_xref="CDD:200449"
     Region          487..577
                     /region_name="gelsolin_S5_like"
                     /note="Gelsolin sub-domain 5-like domain found in
                     gelsolin, severin, villin, and related proteins; cd11288"
                     /db_xref="CDD:200444"
     Site            495
                     /site_type="other"
                     /note="putative nucleotide binding residue [chemical
                     binding]"
                     /db_xref="CDD:200444"
     Region          636..733
                     /region_name="gelsolin_S6_like"
                     /note="Gelsolin sub-domain 6-like domain found in
                     gelsolin, severin, villin, and related proteins; cd11291"
                     /db_xref="CDD:200447"
     Region          805..840
                     /region_name="VHP"
                     /note="Villin headpiece domain; pfam02209"
                     /db_xref="CDD:460493"
     CDS             1..840
                     /gene="AVIL"
                     /gene_synonym="ADVIL; DOC6; NPHS21; p92"
                     /coded_by="XM_054370815.1:3788..6310"
                     /db_xref="GeneID:10677"
                     /db_xref="HGNC:HGNC:14188"
                     /db_xref="MIM:613397"
ORIGIN      
        1 melalvpvsa hgnfyegdcy vilstrrvas llsqdihfwi gkdssqdeqs caaiyttqld
       61 dylggspvqh revqyhesdt frgyfkqgii ykqggvasgm khvetntydv krllhvkgkr
      121 niratevems wdsfnrgdvf lldlgkviiq wngpesnsge rlkamllakd irdrerggra
      181 eigviegdke aaspelmkvl qdtlgrrsii kptvpdeiid qkqkstimly hisdsagqla
      241 vtevatrplv qdllnhddcy ildqsgtkiy vwkgkgatka ekqaamskal gfikmksyps
      301 stnvetvndg aesamfkqlf qkwsvkdqtm glgktfsigk iakvfqdkfd vtllhtkpev
      361 aaqermvddg ngkvevwrie nlelvpveyq wygffyggdc ylvlytyevn gkphhilyiw
      421 qgrhasqdel aasayqavev drqfdgaavq vrvrmgtepr hfmaifkgkl vifeggtsrk
      481 gnaepdppvr lfqihgndks ntkavevpaf asslnsndvf llrtqaehyl wygkgssgde
      541 ramakelasl lcdgsentva egqepaefwd llggktpyan dkrygntasp ssglplparl
      601 vnctkaktsv lktflsslmp lnglycrlqq eildvqsrlf ecsnktgqfv vteitdftqd
      661 dlnptdvmll dtwdqvflwi gaeanateke salataqqyl hthpsgrdpd tpiliikqgf
      721 eppiftgwfl awdpniwsag ktyeqlkeel gdaaaimrit admknatlsl nsndsepkyy
      781 piavllknqn qelpedvnpa kkenylseqd fvsvfgitrg qfaalpgwkq lqmkkekglf
//
LOCUS       XP_054226791             570 aa            linear   PRI 05-AUG-2025
DEFINITION  advillin isoform X4 [Homo sapiens].
ACCESSION   XP_054226791
VERSION     XP_054226791.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370816.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..570
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..570
                     /product="advillin isoform X4"
                     /calculated_mol_wt=63871
     Region          7..118
                     /region_name="gelsolin_S1_like"
                     /note="Gelsolin sub-domain 1-like domain found in
                     gelsolin, severin, villin, and related proteins; cd11290"
                     /db_xref="CDD:200446"
     Site            order(24..25,63,69..70,72..74,76..78,80..81,92,94)
                     /site_type="other"
                     /note="putative actin binding interface [polypeptide
                     binding]"
                     /db_xref="CDD:200446"
     Region          133..223
                     /region_name="gelsolin_S2_like"
                     /note="Gelsolin sub-domain 2-like domain found in
                     gelsolin, severin, villin, and related proteins; cd11289"
                     /db_xref="CDD:200445"
     Region          247..345
                     /region_name="gelsolin_S3_like"
                     /note="Gelsolin sub-domain 3-like domain found in
                     gelsolin, severin, villin, and related proteins; cd11292"
                     /db_xref="CDD:200448"
     Site            order(340,345)
                     /site_type="other"
                     /note="putative nucleotide binding site [chemical
                     binding]"
                     /db_xref="CDD:200448"
     Region          389..489
                     /region_name="gelsolin_S4_like"
                     /note="Gelsolin sub-domain 4-like domain found in
                     gelsolin, severin, villin, and related proteins; cd11293"
                     /db_xref="CDD:200449"
     Site            order(405..406,444,450..451,453..455,457..459,461..462,
                     473,475)
                     /site_type="other"
                     /note="putative actin binding interface [polypeptide
                     binding]"
                     /db_xref="CDD:200449"
     Site            480
                     /site_type="other"
                     /note="putative nucleotide binding residue [chemical
                     binding]"
                     /db_xref="CDD:200449"
     Region          510..>561
                     /region_name="ADF_gelsolin"
                     /note="Actin depolymerization factor/cofilin- and
                     gelsolin-like domains; cl15697"
                     /db_xref="CDD:472830"
     CDS             1..570
                     /gene="AVIL"
                     /gene_synonym="ADVIL; DOC6; NPHS21; p92"
                     /coded_by="XM_054370816.1:3623..5335"
                     /db_xref="GeneID:10677"
                     /db_xref="HGNC:HGNC:14188"
                     /db_xref="MIM:613397"
ORIGIN      
        1 mpltsafrav dndpgiivwr iekmelalvp vsahgnfyeg dcyvilstrr vasllsqdih
       61 fwigkdssqd eqscaaiytt qlddylggsp vqhrevqyhe sdtfrgyfkq giiykqggva
      121 sgmkhvetnt ydvkrllhvk gkrniratev emswdsfnrg dvflldlgkv iiqwngpesn
      181 sgerlkamll akdirdrerg graeigvieg dkeaaspelm kvlqdtlgrr siikptvpde
      241 iidqkqksti mlyhisdsag qlavtevatr plvqdllnhd dcyildqsgt kiyvwkgkga
      301 tkaekqaams kalgfikmks ypsstnvetv ndgaesamfk qlfqkwsvkd qtmglgktfs
      361 igkiakvfqd kfdvtllhtk pevaaqermv ddgngkvevw rienlelvpv eyqwygffyg
      421 gdcylvlyty evngkphhil yiwqgrhasq delaasayqa vevdrqfdga avqvrvrmgt
      481 eprhfmaifk gklvifeggt srkgnaepdp pvrlfqihgn dksntkavev pafasslnsn
      541 dvfllrtqae hylwygktsa gnprcpvssl
//
LOCUS       XP_054226792             564 aa            linear   PRI 05-AUG-2025
DEFINITION  advillin isoform X5 [Homo sapiens].
ACCESSION   XP_054226792
VERSION     XP_054226792.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370817.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..564
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..564
                     /product="advillin isoform X5"
                     /calculated_mol_wt=63105
     Region          <14..46
                     /region_name="ADF_gelsolin"
                     /note="Actin depolymerization factor/cofilin- and
                     gelsolin-like domains; cl15697"
                     /db_xref="CDD:472830"
     Region          90..190
                     /region_name="gelsolin_S4_like"
                     /note="Gelsolin sub-domain 4-like domain found in
                     gelsolin, severin, villin, and related proteins; cd11293"
                     /db_xref="CDD:200449"
     Site            order(106..107,145,151..152,154..156,158..160,162..163,
                     174,176)
                     /site_type="other"
                     /note="putative actin binding interface [polypeptide
                     binding]"
                     /db_xref="CDD:200449"
     Site            181
                     /site_type="other"
                     /note="putative nucleotide binding residue [chemical
                     binding]"
                     /db_xref="CDD:200449"
     Region          211..301
                     /region_name="gelsolin_S5_like"
                     /note="Gelsolin sub-domain 5-like domain found in
                     gelsolin, severin, villin, and related proteins; cd11288"
                     /db_xref="CDD:200444"
     Site            219
                     /site_type="other"
                     /note="putative nucleotide binding residue [chemical
                     binding]"
                     /db_xref="CDD:200444"
     Region          360..457
                     /region_name="gelsolin_S6_like"
                     /note="Gelsolin sub-domain 6-like domain found in
                     gelsolin, severin, villin, and related proteins; cd11291"
                     /db_xref="CDD:200447"
     Region          529..564
                     /region_name="VHP"
                     /note="Villin headpiece domain; pfam02209"
                     /db_xref="CDD:460493"
     CDS             1..564
                     /gene="AVIL"
                     /gene_synonym="ADVIL; DOC6; NPHS21; p92"
                     /coded_by="XM_054370817.1:143..1837"
                     /db_xref="GeneID:10677"
                     /db_xref="HGNC:HGNC:14188"
                     /db_xref="MIM:613397"
ORIGIN      
        1 mcntvqiill ralqgfikmk sypsstnvet vndgaesamf kqlfqkwsvk dqtmglgktf
       61 sigkiakvfq dkfdvtllht kpevaaqerm vddgngkvev wrienlelvp veyqwygffy
      121 ggdcylvlyt yevngkphhi lyiwqgrhas qdelaasayq avevdrqfdg aavqvrvrmg
      181 teprhfmaif kgklvifegg tsrkgnaepd ppvrlfqihg ndksntkave vpafasslns
      241 ndvfllrtqa ehylwygkgs sgderamake lasllcdgse ntvaegqepa efwdllggkt
      301 pyandkrygn taspssglpl parlvnctka ktsvlktfls slmplnglyc rlqqeildvq
      361 srlfecsnkt gqfvvteitd ftqddlnptd vmlldtwdqv flwigaeana tekesalata
      421 qqylhthpsg rdpdtpilii kqgfeppift gwflawdpni wsagktyeql keelgdaaai
      481 mritadmkna tlslnsndse pkyypiavll knqnqelped vnpakkenyl seqdfvsvfg
      541 itrgqfaalp gwkqlqmkke kglf
//
LOCUS       XP_054226793             546 aa            linear   PRI 05-AUG-2025
DEFINITION  advillin isoform X6 [Homo sapiens].
ACCESSION   XP_054226793
VERSION     XP_054226793.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370818.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..546
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..546
                     /product="advillin isoform X6"
                     /calculated_mol_wt=61061
     Region          <1..28
                     /region_name="ADF_gelsolin"
                     /note="Actin depolymerization factor/cofilin- and
                     gelsolin-like domains; cl15697"
                     /db_xref="CDD:472830"
     Region          72..172
                     /region_name="gelsolin_S4_like"
                     /note="Gelsolin sub-domain 4-like domain found in
                     gelsolin, severin, villin, and related proteins; cd11293"
                     /db_xref="CDD:200449"
     Site            order(88..89,127,133..134,136..138,140..142,144..145,156,
                     158)
                     /site_type="other"
                     /note="putative actin binding interface [polypeptide
                     binding]"
                     /db_xref="CDD:200449"
     Site            163
                     /site_type="other"
                     /note="putative nucleotide binding residue [chemical
                     binding]"
                     /db_xref="CDD:200449"
     Region          193..283
                     /region_name="gelsolin_S5_like"
                     /note="Gelsolin sub-domain 5-like domain found in
                     gelsolin, severin, villin, and related proteins; cd11288"
                     /db_xref="CDD:200444"
     Site            201
                     /site_type="other"
                     /note="putative nucleotide binding residue [chemical
                     binding]"
                     /db_xref="CDD:200444"
     Region          342..439
                     /region_name="gelsolin_S6_like"
                     /note="Gelsolin sub-domain 6-like domain found in
                     gelsolin, severin, villin, and related proteins; cd11291"
                     /db_xref="CDD:200447"
     Region          511..546
                     /region_name="VHP"
                     /note="Villin headpiece domain; pfam02209"
                     /db_xref="CDD:460493"
     CDS             1..546
                     /gene="AVIL"
                     /gene_synonym="ADVIL; DOC6; NPHS21; p92"
                     /coded_by="XM_054370818.1:76..1716"
                     /db_xref="GeneID:10677"
                     /db_xref="HGNC:HGNC:14188"
                     /db_xref="MIM:613397"
ORIGIN      
        1 mksypsstnv etvndgaesa mfkqlfqkws vkdqtmglgk tfsigkiakv fqdkfdvtll
       61 htkpevaaqe rmvddgngkv evwrienlel vpveyqwygf fyggdcylvl ytyevngkph
      121 hilyiwqgrh asqdelaasa yqavevdrqf dgaavqvrvr mgteprhfma ifkgklvife
      181 ggtsrkgnae pdppvrlfqi hgndksntka vevpafassl nsndvfllrt qaehylwygk
      241 gssgderama kelasllcdg sentvaegqe paefwdllgg ktpyandkry gntaspssgl
      301 plparlvnct kaktsvlktf lsslmplngl ycrlqqeild vqsrlfecsn ktgqfvvtei
      361 tdftqddlnp tdvmlldtwd qvflwigaea natekesala taqqylhthp sgrdpdtpil
      421 iikqgfeppi ftgwflawdp niwsagktye qlkeelgdaa aimritadmk natlslnsnd
      481 sepkyypiav llknqnqelp edvnpakken ylseqdfvsv fgitrgqfaa lpgwkqlqmk
      541 kekglf
//
LOCUS       XP_054226794             165 aa            linear   PRI 05-AUG-2025
DEFINITION  prostaglandin E synthase 3 isoform X1 [Homo sapiens].
ACCESSION   XP_054226794
VERSION     XP_054226794.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370819.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..165
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..165
                     /product="prostaglandin E synthase 3 isoform X1"
                     /calculated_mol_wt=19318
     Region          7..113
                     /region_name="p23"
                     /note="p23 binds heat shock protein (Hsp)90 and
                     participates in the folding of a number of Hsp90 clients,
                     including the progesterone receptor. p23 also has a
                     passive chaperoning activity and in addition may
                     participate in prostaglandin synthesis; cd00237"
                     /db_xref="CDD:107218"
     Site            order(12,57,91..94,103,107,110)
                     /site_type="other"
                     /note="putative Hsp90 binding site [polypeptide binding]"
                     /db_xref="CDD:107218"
     Site            order(60,62,92,95..97)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:107218"
     CDS             1..165
                     /gene="PTGES3"
                     /gene_synonym="cPGES; P23; TEBP"
                     /coded_by="XM_054370819.1:3069..3566"
                     /db_xref="GeneID:10728"
                     /db_xref="HGNC:HGNC:16049"
                     /db_xref="MIM:607061"
ORIGIN      
        1 mfylrqpasa kwydrrdyvf iefcvedskd vnvnfekskl tfsclggsdn fkhlneidlf
       61 hcidpndskh krtdrsilcc lrkgesgqsw prltkerakl nwlsvdfnnw kdweddsded
      121 msnfdrfsem mnnmggdedv dlpevdgadd vslkilfsvy fhtik
//
LOCUS       XP_054226795             164 aa            linear   PRI 05-AUG-2025
DEFINITION  prostaglandin E synthase 3 isoform X2 [Homo sapiens].
ACCESSION   XP_054226795
VERSION     XP_054226795.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370820.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..164
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..164
                     /product="prostaglandin E synthase 3 isoform X2"
                     /calculated_mol_wt=19146
     Region          7..113
                     /region_name="p23"
                     /note="p23 binds heat shock protein (Hsp)90 and
                     participates in the folding of a number of Hsp90 clients,
                     including the progesterone receptor. p23 also has a
                     passive chaperoning activity and in addition may
                     participate in prostaglandin synthesis; cd00237"
                     /db_xref="CDD:107218"
     Site            order(12,57,91..94,103,107,110)
                     /site_type="other"
                     /note="putative Hsp90 binding site [polypeptide binding]"
                     /db_xref="CDD:107218"
     Site            order(60,62,92,95..97)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:107218"
     CDS             1..164
                     /gene="PTGES3"
                     /gene_synonym="cPGES; P23; TEBP"
                     /coded_by="XM_054370820.1:3069..3563"
                     /db_xref="GeneID:10728"
                     /db_xref="HGNC:HGNC:16049"
                     /db_xref="MIM:607061"
ORIGIN      
        1 mfylrqpasa kwydrrdyvf iefcvedskd vnvnfekskl tfsclggsdn fkhlneidlf
       61 hcidpndskh krtdrsilcc lrkgesgqsw prltkerakl nwlsvdfnnw kdweddsded
      121 msnfdrfsem mnnmggdedv dlpevdgadd dsqdsddekm pdle
//
LOCUS       XP_054226796             161 aa            linear   PRI 05-AUG-2025
DEFINITION  prostaglandin E synthase 3 isoform X3 [Homo sapiens].
ACCESSION   XP_054226796
VERSION     XP_054226796.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370821.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..161
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..161
                     /product="prostaglandin E synthase 3 isoform X3"
                     /calculated_mol_wt=18738
     Region          3..109
                     /region_name="p23"
                     /note="p23 binds heat shock protein (Hsp)90 and
                     participates in the folding of a number of Hsp90 clients,
                     including the progesterone receptor. p23 also has a
                     passive chaperoning activity and in addition may
                     participate in prostaglandin synthesis; cd00237"
                     /db_xref="CDD:107218"
     Site            order(8,53,87..90,99,103,106)
                     /site_type="other"
                     /note="putative Hsp90 binding site [polypeptide binding]"
                     /db_xref="CDD:107218"
     Site            order(56,58,88,91..93)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:107218"
     CDS             1..161
                     /gene="PTGES3"
                     /gene_synonym="cPGES; P23; TEBP"
                     /coded_by="XM_054370821.1:286..771"
                     /db_xref="GeneID:10728"
                     /db_xref="HGNC:HGNC:16049"
                     /db_xref="MIM:607061"
ORIGIN      
        1 mqpasakwyd rrdyvfiefc vedskdvnvn fekskltfsc lggsdnfkhl neidlfhcid
       61 pndskhkrtd rsilcclrkg esgqswprlt keraklnwls vdfnnwkdwe ddsdedmsnf
      121 drfsemmnnm ggdedvdlpe vdgaddvslk ilfsvyfhti k
//
LOCUS       XP_054226797             143 aa            linear   PRI 05-AUG-2025
DEFINITION  prostaglandin E synthase 3 isoform X4 [Homo sapiens].
ACCESSION   XP_054226797
VERSION     XP_054226797.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370822.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..143
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..143
                     /product="prostaglandin E synthase 3 isoform X4"
                     /calculated_mol_wt=16925
     Region          7..113
                     /region_name="p23"
                     /note="p23 binds heat shock protein (Hsp)90 and
                     participates in the folding of a number of Hsp90 clients,
                     including the progesterone receptor. p23 also has a
                     passive chaperoning activity and in addition may
                     participate in prostaglandin synthesis; cd00237"
                     /db_xref="CDD:107218"
     Site            order(12,57,91..94,103,107,110)
                     /site_type="other"
                     /note="putative Hsp90 binding site [polypeptide binding]"
                     /db_xref="CDD:107218"
     Site            order(60,62,92,95..97)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:107218"
     CDS             1..143
                     /gene="PTGES3"
                     /gene_synonym="cPGES; P23; TEBP"
                     /coded_by="XM_054370822.1:3069..3500"
                     /db_xref="GeneID:10728"
                     /db_xref="HGNC:HGNC:16049"
                     /db_xref="MIM:607061"
ORIGIN      
        1 mfylrqpasa kwydrrdyvf iefcvedskd vnvnfekskl tfsclggsdn fkhlneidlf
       61 hcidpndskh krtdrsilcc lrkgesgqsw prltkerakl nwlsvdfnnw kdweddsded
      121 msnfdrfsed sqdsddekmp dle
//
LOCUS       XP_054226798             134 aa            linear   PRI 05-AUG-2025
DEFINITION  prostaglandin E synthase 3 isoform X5 [Homo sapiens].
ACCESSION   XP_054226798
VERSION     XP_054226798.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370823.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..134
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..134
                     /product="prostaglandin E synthase 3 isoform X5"
                     /calculated_mol_wt=15407
     Region          7..99
                     /region_name="alpha-crystallin domain (ACD) found in
                     alpha-crystallin-type small heat shock proteins, and a
                     similar domain found in p23 (a cochaperone for Hsp90) and
                     in other p23-like proteins."
                     /note="The alpha-crystallin-Hsps_p23-like superfamily
                     includes the alpha-crystallin domain (ACD) of
                     alpha-crystallin-type small heat shock proteins (sHsps)
                     and a similar domain found in p23-like proteins. sHsps are
                     small stress induced proteins with monomeric...; cl00175"
                     /db_xref="CDD:469641"
     CDS             1..134
                     /gene="PTGES3"
                     /gene_synonym="cPGES; P23; TEBP"
                     /coded_by="XM_054370823.1:3069..3473"
                     /db_xref="GeneID:10728"
                     /db_xref="HGNC:HGNC:16049"
                     /db_xref="MIM:607061"
ORIGIN      
        1 mfylrqpasa kwydrrdyvf iefcvedskd vnvnfekskl tfsclggsdn fkhlneidlf
       61 hcidpndskh krtdrsilcc lrkgesgqsw prltkerakm mnnmggdedv dlpevdgadd
      121 dsqdsddekm pdle
//
LOCUS       XP_054226799             508 aa            linear   PRI 05-AUG-2025
DEFINITION  fibroblast growth factor receptor substrate 2 isoform X1 [Homo
            sapiens].
ACCESSION   XP_054226799
VERSION     XP_054226799.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370824.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..508
                     /product="fibroblast growth factor receptor substrate 2
                     isoform X1"
                     /calculated_mol_wt=56898
     Region          15..106
                     /region_name="PTB_FRS2"
                     /note="Fibroblast growth factor receptor substrate 2
                     phosphotyrosine-binding domain; cd01202"
                     /db_xref="CDD:269913"
     Site            order(25..28,33,36,47,49..50,55,57,60,62..69,71,73..74,82,
                     85..89,98,102,105)
                     /site_type="other"
                     /note="phosphopeptide binding site [polypeptide binding]"
                     /db_xref="CDD:269913"
     CDS             1..508
                     /gene="FRS2"
                     /gene_synonym="FRS1A; FRS2A; FRS2alpha; SNT; SNT-1; SNT1"
                     /coded_by="XM_054370824.1:574..2100"
                     /db_xref="GeneID:10818"
                     /db_xref="HGNC:HGNC:16971"
                     /db_xref="MIM:607743"
ORIGIN      
        1 mgsccscpdk dtvpdnhrnk fkvinvdddg nelgsgimel tdtelilytr krdsvkwhyl
       61 clrrygydsn lfsfesgrrc qtgqgifafk caraeelfnm lqeimqnnsi nvveepvver
      121 nnhqtelevp rtprtpttpg faaqnlpngy prypsfgdas shpssrhpsv gsarlpsvge
      181 esthpllvae eqvhtyvntt gvqeerknrt svhvplearv snaesstpke epssiedrdp
      241 qillepegvk fvlgptpvqk qlmekekleq lgrdqvsgsg anntewdtgy dsderrdaps
      301 vnklvyenin glsipsasgv rrgrltstst sdtqninnsa qrrtallnye nlpslppvwe
      361 arklsrdedd nlgpktpsln gyhnnldpmh nyvntenvtv pasahkieys rrrdctptvf
      421 nfdirrpsle hrqlnyiqvd leggsdsdnp qtpktpttpl pqtptrrtel yavidierta
      481 amsnlqkalp rddgtsrktr hnstdlpm
//
LOCUS       XP_054226800             508 aa            linear   PRI 05-AUG-2025
DEFINITION  fibroblast growth factor receptor substrate 2 isoform X1 [Homo
            sapiens].
ACCESSION   XP_054226800
VERSION     XP_054226800.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370825.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..508
                     /product="fibroblast growth factor receptor substrate 2
                     isoform X1"
                     /calculated_mol_wt=56898
     Region          15..106
                     /region_name="PTB_FRS2"
                     /note="Fibroblast growth factor receptor substrate 2
                     phosphotyrosine-binding domain; cd01202"
                     /db_xref="CDD:269913"
     Site            order(25..28,33,36,47,49..50,55,57,60,62..69,71,73..74,82,
                     85..89,98,102,105)
                     /site_type="other"
                     /note="phosphopeptide binding site [polypeptide binding]"
                     /db_xref="CDD:269913"
     CDS             1..508
                     /gene="FRS2"
                     /gene_synonym="FRS1A; FRS2A; FRS2alpha; SNT; SNT-1; SNT1"
                     /coded_by="XM_054370825.1:461..1987"
                     /db_xref="GeneID:10818"
                     /db_xref="HGNC:HGNC:16971"
                     /db_xref="MIM:607743"
ORIGIN      
        1 mgsccscpdk dtvpdnhrnk fkvinvdddg nelgsgimel tdtelilytr krdsvkwhyl
       61 clrrygydsn lfsfesgrrc qtgqgifafk caraeelfnm lqeimqnnsi nvveepvver
      121 nnhqtelevp rtprtpttpg faaqnlpngy prypsfgdas shpssrhpsv gsarlpsvge
      181 esthpllvae eqvhtyvntt gvqeerknrt svhvplearv snaesstpke epssiedrdp
      241 qillepegvk fvlgptpvqk qlmekekleq lgrdqvsgsg anntewdtgy dsderrdaps
      301 vnklvyenin glsipsasgv rrgrltstst sdtqninnsa qrrtallnye nlpslppvwe
      361 arklsrdedd nlgpktpsln gyhnnldpmh nyvntenvtv pasahkieys rrrdctptvf
      421 nfdirrpsle hrqlnyiqvd leggsdsdnp qtpktpttpl pqtptrrtel yavidierta
      481 amsnlqkalp rddgtsrktr hnstdlpm
//
LOCUS       XP_054226801             508 aa            linear   PRI 05-AUG-2025
DEFINITION  fibroblast growth factor receptor substrate 2 isoform X1 [Homo
            sapiens].
ACCESSION   XP_054226801
VERSION     XP_054226801.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370826.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..508
                     /product="fibroblast growth factor receptor substrate 2
                     isoform X1"
                     /calculated_mol_wt=56898
     Region          15..106
                     /region_name="PTB_FRS2"
                     /note="Fibroblast growth factor receptor substrate 2
                     phosphotyrosine-binding domain; cd01202"
                     /db_xref="CDD:269913"
     Site            order(25..28,33,36,47,49..50,55,57,60,62..69,71,73..74,82,
                     85..89,98,102,105)
                     /site_type="other"
                     /note="phosphopeptide binding site [polypeptide binding]"
                     /db_xref="CDD:269913"
     CDS             1..508
                     /gene="FRS2"
                     /gene_synonym="FRS1A; FRS2A; FRS2alpha; SNT; SNT-1; SNT1"
                     /coded_by="XM_054370826.1:568..2094"
                     /db_xref="GeneID:10818"
                     /db_xref="HGNC:HGNC:16971"
                     /db_xref="MIM:607743"
ORIGIN      
        1 mgsccscpdk dtvpdnhrnk fkvinvdddg nelgsgimel tdtelilytr krdsvkwhyl
       61 clrrygydsn lfsfesgrrc qtgqgifafk caraeelfnm lqeimqnnsi nvveepvver
      121 nnhqtelevp rtprtpttpg faaqnlpngy prypsfgdas shpssrhpsv gsarlpsvge
      181 esthpllvae eqvhtyvntt gvqeerknrt svhvplearv snaesstpke epssiedrdp
      241 qillepegvk fvlgptpvqk qlmekekleq lgrdqvsgsg anntewdtgy dsderrdaps
      301 vnklvyenin glsipsasgv rrgrltstst sdtqninnsa qrrtallnye nlpslppvwe
      361 arklsrdedd nlgpktpsln gyhnnldpmh nyvntenvtv pasahkieys rrrdctptvf
      421 nfdirrpsle hrqlnyiqvd leggsdsdnp qtpktpttpl pqtptrrtel yavidierta
      481 amsnlqkalp rddgtsrktr hnstdlpm
//
LOCUS       XP_054226802             508 aa            linear   PRI 05-AUG-2025
DEFINITION  fibroblast growth factor receptor substrate 2 isoform X1 [Homo
            sapiens].
ACCESSION   XP_054226802
VERSION     XP_054226802.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370827.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..508
                     /product="fibroblast growth factor receptor substrate 2
                     isoform X1"
                     /calculated_mol_wt=56898
     Region          15..106
                     /region_name="PTB_FRS2"
                     /note="Fibroblast growth factor receptor substrate 2
                     phosphotyrosine-binding domain; cd01202"
                     /db_xref="CDD:269913"
     Site            order(25..28,33,36,47,49..50,55,57,60,62..69,71,73..74,82,
                     85..89,98,102,105)
                     /site_type="other"
                     /note="phosphopeptide binding site [polypeptide binding]"
                     /db_xref="CDD:269913"
     CDS             1..508
                     /gene="FRS2"
                     /gene_synonym="FRS1A; FRS2A; FRS2alpha; SNT; SNT-1; SNT1"
                     /coded_by="XM_054370827.1:3677..5203"
                     /db_xref="GeneID:10818"
                     /db_xref="HGNC:HGNC:16971"
                     /db_xref="MIM:607743"
ORIGIN      
        1 mgsccscpdk dtvpdnhrnk fkvinvdddg nelgsgimel tdtelilytr krdsvkwhyl
       61 clrrygydsn lfsfesgrrc qtgqgifafk caraeelfnm lqeimqnnsi nvveepvver
      121 nnhqtelevp rtprtpttpg faaqnlpngy prypsfgdas shpssrhpsv gsarlpsvge
      181 esthpllvae eqvhtyvntt gvqeerknrt svhvplearv snaesstpke epssiedrdp
      241 qillepegvk fvlgptpvqk qlmekekleq lgrdqvsgsg anntewdtgy dsderrdaps
      301 vnklvyenin glsipsasgv rrgrltstst sdtqninnsa qrrtallnye nlpslppvwe
      361 arklsrdedd nlgpktpsln gyhnnldpmh nyvntenvtv pasahkieys rrrdctptvf
      421 nfdirrpsle hrqlnyiqvd leggsdsdnp qtpktpttpl pqtptrrtel yavidierta
      481 amsnlqkalp rddgtsrktr hnstdlpm
//
LOCUS       XP_054226803             508 aa            linear   PRI 05-AUG-2025
DEFINITION  fibroblast growth factor receptor substrate 2 isoform X1 [Homo
            sapiens].
ACCESSION   XP_054226803
VERSION     XP_054226803.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370828.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..508
                     /product="fibroblast growth factor receptor substrate 2
                     isoform X1"
                     /calculated_mol_wt=56898
     Region          15..106
                     /region_name="PTB_FRS2"
                     /note="Fibroblast growth factor receptor substrate 2
                     phosphotyrosine-binding domain; cd01202"
                     /db_xref="CDD:269913"
     Site            order(25..28,33,36,47,49..50,55,57,60,62..69,71,73..74,82,
                     85..89,98,102,105)
                     /site_type="other"
                     /note="phosphopeptide binding site [polypeptide binding]"
                     /db_xref="CDD:269913"
     CDS             1..508
                     /gene="FRS2"
                     /gene_synonym="FRS1A; FRS2A; FRS2alpha; SNT; SNT-1; SNT1"
                     /coded_by="XM_054370828.1:332..1858"
                     /db_xref="GeneID:10818"
                     /db_xref="HGNC:HGNC:16971"
                     /db_xref="MIM:607743"
ORIGIN      
        1 mgsccscpdk dtvpdnhrnk fkvinvdddg nelgsgimel tdtelilytr krdsvkwhyl
       61 clrrygydsn lfsfesgrrc qtgqgifafk caraeelfnm lqeimqnnsi nvveepvver
      121 nnhqtelevp rtprtpttpg faaqnlpngy prypsfgdas shpssrhpsv gsarlpsvge
      181 esthpllvae eqvhtyvntt gvqeerknrt svhvplearv snaesstpke epssiedrdp
      241 qillepegvk fvlgptpvqk qlmekekleq lgrdqvsgsg anntewdtgy dsderrdaps
      301 vnklvyenin glsipsasgv rrgrltstst sdtqninnsa qrrtallnye nlpslppvwe
      361 arklsrdedd nlgpktpsln gyhnnldpmh nyvntenvtv pasahkieys rrrdctptvf
      421 nfdirrpsle hrqlnyiqvd leggsdsdnp qtpktpttpl pqtptrrtel yavidierta
      481 amsnlqkalp rddgtsrktr hnstdlpm
//
LOCUS       XP_054226804             508 aa            linear   PRI 05-AUG-2025
DEFINITION  fibroblast growth factor receptor substrate 2 isoform X1 [Homo
            sapiens].
ACCESSION   XP_054226804
VERSION     XP_054226804.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370829.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..508
                     /product="fibroblast growth factor receptor substrate 2
                     isoform X1"
                     /calculated_mol_wt=56898
     Region          15..106
                     /region_name="PTB_FRS2"
                     /note="Fibroblast growth factor receptor substrate 2
                     phosphotyrosine-binding domain; cd01202"
                     /db_xref="CDD:269913"
     Site            order(25..28,33,36,47,49..50,55,57,60,62..69,71,73..74,82,
                     85..89,98,102,105)
                     /site_type="other"
                     /note="phosphopeptide binding site [polypeptide binding]"
                     /db_xref="CDD:269913"
     CDS             1..508
                     /gene="FRS2"
                     /gene_synonym="FRS1A; FRS2A; FRS2alpha; SNT; SNT-1; SNT1"
                     /coded_by="XM_054370829.1:4223..5749"
                     /db_xref="GeneID:10818"
                     /db_xref="HGNC:HGNC:16971"
                     /db_xref="MIM:607743"
ORIGIN      
        1 mgsccscpdk dtvpdnhrnk fkvinvdddg nelgsgimel tdtelilytr krdsvkwhyl
       61 clrrygydsn lfsfesgrrc qtgqgifafk caraeelfnm lqeimqnnsi nvveepvver
      121 nnhqtelevp rtprtpttpg faaqnlpngy prypsfgdas shpssrhpsv gsarlpsvge
      181 esthpllvae eqvhtyvntt gvqeerknrt svhvplearv snaesstpke epssiedrdp
      241 qillepegvk fvlgptpvqk qlmekekleq lgrdqvsgsg anntewdtgy dsderrdaps
      301 vnklvyenin glsipsasgv rrgrltstst sdtqninnsa qrrtallnye nlpslppvwe
      361 arklsrdedd nlgpktpsln gyhnnldpmh nyvntenvtv pasahkieys rrrdctptvf
      421 nfdirrpsle hrqlnyiqvd leggsdsdnp qtpktpttpl pqtptrrtel yavidierta
      481 amsnlqkalp rddgtsrktr hnstdlpm
//
LOCUS       XP_054226805             508 aa            linear   PRI 05-AUG-2025
DEFINITION  fibroblast growth factor receptor substrate 2 isoform X1 [Homo
            sapiens].
ACCESSION   XP_054226805
VERSION     XP_054226805.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370830.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..508
                     /product="fibroblast growth factor receptor substrate 2
                     isoform X1"
                     /calculated_mol_wt=56898
     Region          15..106
                     /region_name="PTB_FRS2"
                     /note="Fibroblast growth factor receptor substrate 2
                     phosphotyrosine-binding domain; cd01202"
                     /db_xref="CDD:269913"
     Site            order(25..28,33,36,47,49..50,55,57,60,62..69,71,73..74,82,
                     85..89,98,102,105)
                     /site_type="other"
                     /note="phosphopeptide binding site [polypeptide binding]"
                     /db_xref="CDD:269913"
     CDS             1..508
                     /gene="FRS2"
                     /gene_synonym="FRS1A; FRS2A; FRS2alpha; SNT; SNT-1; SNT1"
                     /coded_by="XM_054370830.1:411..1937"
                     /db_xref="GeneID:10818"
                     /db_xref="HGNC:HGNC:16971"
                     /db_xref="MIM:607743"
ORIGIN      
        1 mgsccscpdk dtvpdnhrnk fkvinvdddg nelgsgimel tdtelilytr krdsvkwhyl
       61 clrrygydsn lfsfesgrrc qtgqgifafk caraeelfnm lqeimqnnsi nvveepvver
      121 nnhqtelevp rtprtpttpg faaqnlpngy prypsfgdas shpssrhpsv gsarlpsvge
      181 esthpllvae eqvhtyvntt gvqeerknrt svhvplearv snaesstpke epssiedrdp
      241 qillepegvk fvlgptpvqk qlmekekleq lgrdqvsgsg anntewdtgy dsderrdaps
      301 vnklvyenin glsipsasgv rrgrltstst sdtqninnsa qrrtallnye nlpslppvwe
      361 arklsrdedd nlgpktpsln gyhnnldpmh nyvntenvtv pasahkieys rrrdctptvf
      421 nfdirrpsle hrqlnyiqvd leggsdsdnp qtpktpttpl pqtptrrtel yavidierta
      481 amsnlqkalp rddgtsrktr hnstdlpm
//
LOCUS       XP_054226806             508 aa            linear   PRI 05-AUG-2025
DEFINITION  fibroblast growth factor receptor substrate 2 isoform X1 [Homo
            sapiens].
ACCESSION   XP_054226806
VERSION     XP_054226806.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370831.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..508
                     /product="fibroblast growth factor receptor substrate 2
                     isoform X1"
                     /calculated_mol_wt=56898
     Region          15..106
                     /region_name="PTB_FRS2"
                     /note="Fibroblast growth factor receptor substrate 2
                     phosphotyrosine-binding domain; cd01202"
                     /db_xref="CDD:269913"
     Site            order(25..28,33,36,47,49..50,55,57,60,62..69,71,73..74,82,
                     85..89,98,102,105)
                     /site_type="other"
                     /note="phosphopeptide binding site [polypeptide binding]"
                     /db_xref="CDD:269913"
     CDS             1..508
                     /gene="FRS2"
                     /gene_synonym="FRS1A; FRS2A; FRS2alpha; SNT; SNT-1; SNT1"
                     /coded_by="XM_054370831.1:279..1805"
                     /db_xref="GeneID:10818"
                     /db_xref="HGNC:HGNC:16971"
                     /db_xref="MIM:607743"
ORIGIN      
        1 mgsccscpdk dtvpdnhrnk fkvinvdddg nelgsgimel tdtelilytr krdsvkwhyl
       61 clrrygydsn lfsfesgrrc qtgqgifafk caraeelfnm lqeimqnnsi nvveepvver
      121 nnhqtelevp rtprtpttpg faaqnlpngy prypsfgdas shpssrhpsv gsarlpsvge
      181 esthpllvae eqvhtyvntt gvqeerknrt svhvplearv snaesstpke epssiedrdp
      241 qillepegvk fvlgptpvqk qlmekekleq lgrdqvsgsg anntewdtgy dsderrdaps
      301 vnklvyenin glsipsasgv rrgrltstst sdtqninnsa qrrtallnye nlpslppvwe
      361 arklsrdedd nlgpktpsln gyhnnldpmh nyvntenvtv pasahkieys rrrdctptvf
      421 nfdirrpsle hrqlnyiqvd leggsdsdnp qtpktpttpl pqtptrrtel yavidierta
      481 amsnlqkalp rddgtsrktr hnstdlpm
//
LOCUS       XP_054226807             508 aa            linear   PRI 05-AUG-2025
DEFINITION  fibroblast growth factor receptor substrate 2 isoform X1 [Homo
            sapiens].
ACCESSION   XP_054226807
VERSION     XP_054226807.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370832.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..508
                     /product="fibroblast growth factor receptor substrate 2
                     isoform X1"
                     /calculated_mol_wt=56898
     Region          15..106
                     /region_name="PTB_FRS2"
                     /note="Fibroblast growth factor receptor substrate 2
                     phosphotyrosine-binding domain; cd01202"
                     /db_xref="CDD:269913"
     Site            order(25..28,33,36,47,49..50,55,57,60,62..69,71,73..74,82,
                     85..89,98,102,105)
                     /site_type="other"
                     /note="phosphopeptide binding site [polypeptide binding]"
                     /db_xref="CDD:269913"
     CDS             1..508
                     /gene="FRS2"
                     /gene_synonym="FRS1A; FRS2A; FRS2alpha; SNT; SNT-1; SNT1"
                     /coded_by="XM_054370832.1:644..2170"
                     /db_xref="GeneID:10818"
                     /db_xref="HGNC:HGNC:16971"
                     /db_xref="MIM:607743"
ORIGIN      
        1 mgsccscpdk dtvpdnhrnk fkvinvdddg nelgsgimel tdtelilytr krdsvkwhyl
       61 clrrygydsn lfsfesgrrc qtgqgifafk caraeelfnm lqeimqnnsi nvveepvver
      121 nnhqtelevp rtprtpttpg faaqnlpngy prypsfgdas shpssrhpsv gsarlpsvge
      181 esthpllvae eqvhtyvntt gvqeerknrt svhvplearv snaesstpke epssiedrdp
      241 qillepegvk fvlgptpvqk qlmekekleq lgrdqvsgsg anntewdtgy dsderrdaps
      301 vnklvyenin glsipsasgv rrgrltstst sdtqninnsa qrrtallnye nlpslppvwe
      361 arklsrdedd nlgpktpsln gyhnnldpmh nyvntenvtv pasahkieys rrrdctptvf
      421 nfdirrpsle hrqlnyiqvd leggsdsdnp qtpktpttpl pqtptrrtel yavidierta
      481 amsnlqkalp rddgtsrktr hnstdlpm
//
LOCUS       XP_054226808             239 aa            linear   PRI 05-AUG-2025
DEFINITION  tetraspanin-9 isoform X2 [Homo sapiens].
ACCESSION   XP_054226808
VERSION     XP_054226808.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370833.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..239
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..239
                     /product="tetraspanin-9 isoform X2"
                     /calculated_mol_wt=26648
     Region          9..228
                     /region_name="Tetraspanin"
                     /note="Tetraspanin family; pfam00335"
                     /db_xref="CDD:459767"
     Region          105..202
                     /region_name="NET-5_like_LEL"
                     /note="Tetraspanin, extracellular domain or large
                     extracellular loop (LEL), NET-5_like family. Tetraspanins
                     are trans-membrane proteins with 4 trans-membrane
                     segments. Both the N- and C-termini lie on the
                     intracellular side of the membrane. This alignment
                     model...; cd03165"
                     /db_xref="CDD:239418"
     Site            order(106,111,115,117..118,121,137,140..141,144..145)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:239418"
     CDS             1..239
                     /gene="TSPAN9"
                     /gene_synonym="NET-5; NET5; PP1057"
                     /coded_by="XM_054370833.1:291..1010"
                     /db_xref="GeneID:10867"
                     /db_xref="HGNC:HGNC:21640"
                     /db_xref="MIM:613137"
ORIGIN      
        1 margclcclk ymmflfnlif wlcgcgllgv giwlsvsqgn fatfspsfps lsaanlviai
       61 gtivmvtgfl gclgaikenk clllsffivl lvillaelil lilffvymdk vnenakkdlk
      121 eglllyhten nvglknawni iqaemrccgv tdytdwypvl gentvpdrcc mensqgcgrn
      181 attplwrtgc yekvkmwfdd nkhvlgtvgm cilimqilgm afsmtlfqhi hrtgkkyda
//
LOCUS       XP_054226809             239 aa            linear   PRI 05-AUG-2025
DEFINITION  tetraspanin-9 isoform X2 [Homo sapiens].
ACCESSION   XP_054226809
VERSION     XP_054226809.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370834.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..239
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..239
                     /product="tetraspanin-9 isoform X2"
                     /calculated_mol_wt=26648
     Region          9..228
                     /region_name="Tetraspanin"
                     /note="Tetraspanin family; pfam00335"
                     /db_xref="CDD:459767"
     Region          105..202
                     /region_name="NET-5_like_LEL"
                     /note="Tetraspanin, extracellular domain or large
                     extracellular loop (LEL), NET-5_like family. Tetraspanins
                     are trans-membrane proteins with 4 trans-membrane
                     segments. Both the N- and C-termini lie on the
                     intracellular side of the membrane. This alignment
                     model...; cd03165"
                     /db_xref="CDD:239418"
     Site            order(106,111,115,117..118,121,137,140..141,144..145)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:239418"
     CDS             1..239
                     /gene="TSPAN9"
                     /gene_synonym="NET-5; NET5; PP1057"
                     /coded_by="XM_054370834.1:315..1034"
                     /db_xref="GeneID:10867"
                     /db_xref="HGNC:HGNC:21640"
                     /db_xref="MIM:613137"
ORIGIN      
        1 margclcclk ymmflfnlif wlcgcgllgv giwlsvsqgn fatfspsfps lsaanlviai
       61 gtivmvtgfl gclgaikenk clllsffivl lvillaelil lilffvymdk vnenakkdlk
      121 eglllyhten nvglknawni iqaemrccgv tdytdwypvl gentvpdrcc mensqgcgrn
      181 attplwrtgc yekvkmwfdd nkhvlgtvgm cilimqilgm afsmtlfqhi hrtgkkyda
//
LOCUS       XP_054226810             239 aa            linear   PRI 05-AUG-2025
DEFINITION  tetraspanin-9 isoform X2 [Homo sapiens].
ACCESSION   XP_054226810
VERSION     XP_054226810.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370835.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..239
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..239
                     /product="tetraspanin-9 isoform X2"
                     /calculated_mol_wt=26648
     Region          9..228
                     /region_name="Tetraspanin"
                     /note="Tetraspanin family; pfam00335"
                     /db_xref="CDD:459767"
     Region          105..202
                     /region_name="NET-5_like_LEL"
                     /note="Tetraspanin, extracellular domain or large
                     extracellular loop (LEL), NET-5_like family. Tetraspanins
                     are trans-membrane proteins with 4 trans-membrane
                     segments. Both the N- and C-termini lie on the
                     intracellular side of the membrane. This alignment
                     model...; cd03165"
                     /db_xref="CDD:239418"
     Site            order(106,111,115,117..118,121,137,140..141,144..145)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:239418"
     CDS             1..239
                     /gene="TSPAN9"
                     /gene_synonym="NET-5; NET5; PP1057"
                     /coded_by="XM_054370835.1:305..1024"
                     /db_xref="GeneID:10867"
                     /db_xref="HGNC:HGNC:21640"
                     /db_xref="MIM:613137"
ORIGIN      
        1 margclcclk ymmflfnlif wlcgcgllgv giwlsvsqgn fatfspsfps lsaanlviai
       61 gtivmvtgfl gclgaikenk clllsffivl lvillaelil lilffvymdk vnenakkdlk
      121 eglllyhten nvglknawni iqaemrccgv tdytdwypvl gentvpdrcc mensqgcgrn
      181 attplwrtgc yekvkmwfdd nkhvlgtvgm cilimqilgm afsmtlfqhi hrtgkkyda
//
LOCUS       XP_054226811             175 aa            linear   PRI 05-AUG-2025
DEFINITION  tetraspanin-9 isoform X3 [Homo sapiens].
ACCESSION   XP_054226811
VERSION     XP_054226811.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370836.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..175
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..175
                     /product="tetraspanin-9 isoform X3"
                     /calculated_mol_wt=19798
     Region          <1..164
                     /region_name="Tetraspanin"
                     /note="Tetraspanin family; pfam00335"
                     /db_xref="CDD:459767"
     Region          41..138
                     /region_name="NET-5_like_LEL"
                     /note="Tetraspanin, extracellular domain or large
                     extracellular loop (LEL), NET-5_like family. Tetraspanins
                     are trans-membrane proteins with 4 trans-membrane
                     segments. Both the N- and C-termini lie on the
                     intracellular side of the membrane. This alignment
                     model...; cd03165"
                     /db_xref="CDD:239418"
     Site            order(42,47,51,53..54,57,73,76..77,80..81)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:239418"
     CDS             1..175
                     /gene="TSPAN9"
                     /gene_synonym="NET-5; NET5; PP1057"
                     /coded_by="XM_054370836.1:491..1018"
                     /db_xref="GeneID:10867"
                     /db_xref="HGNC:HGNC:21640"
                     /db_xref="MIM:613137"
ORIGIN      
        1 mvtgflgclg aikenkclll sffivllvil laelillilf fvymdkvnen akkdlkegll
       61 lyhtennvgl knawniiqae mrccgvtdyt dwypvlgent vpdrccmens qgcgrnattp
      121 lwrtgcyekv kmwfddnkhv lgtvgmcili mqilgmafsm tlfqhihrtg kkyda
//
LOCUS       XP_054226812             175 aa            linear   PRI 05-AUG-2025
DEFINITION  tetraspanin-9 isoform X3 [Homo sapiens].
ACCESSION   XP_054226812
VERSION     XP_054226812.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370837.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..175
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..175
                     /product="tetraspanin-9 isoform X3"
                     /calculated_mol_wt=19798
     Region          <1..164
                     /region_name="Tetraspanin"
                     /note="Tetraspanin family; pfam00335"
                     /db_xref="CDD:459767"
     Region          41..138
                     /region_name="NET-5_like_LEL"
                     /note="Tetraspanin, extracellular domain or large
                     extracellular loop (LEL), NET-5_like family. Tetraspanins
                     are trans-membrane proteins with 4 trans-membrane
                     segments. Both the N- and C-termini lie on the
                     intracellular side of the membrane. This alignment
                     model...; cd03165"
                     /db_xref="CDD:239418"
     Site            order(42,47,51,53..54,57,73,76..77,80..81)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:239418"
     CDS             1..175
                     /gene="TSPAN9"
                     /gene_synonym="NET-5; NET5; PP1057"
                     /coded_by="XM_054370837.1:1643..2170"
                     /db_xref="GeneID:10867"
                     /db_xref="HGNC:HGNC:21640"
                     /db_xref="MIM:613137"
ORIGIN      
        1 mvtgflgclg aikenkclll sffivllvil laelillilf fvymdkvnen akkdlkegll
       61 lyhtennvgl knawniiqae mrccgvtdyt dwypvlgent vpdrccmens qgcgrnattp
      121 lwrtgcyekv kmwfddnkhv lgtvgmcili mqilgmafsm tlfqhihrtg kkyda
//
LOCUS       XP_054226813             175 aa            linear   PRI 05-AUG-2025
DEFINITION  tetraspanin-9 isoform X3 [Homo sapiens].
ACCESSION   XP_054226813
VERSION     XP_054226813.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370838.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..175
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..175
                     /product="tetraspanin-9 isoform X3"
                     /calculated_mol_wt=19798
     Region          <1..164
                     /region_name="Tetraspanin"
                     /note="Tetraspanin family; pfam00335"
                     /db_xref="CDD:459767"
     Region          41..138
                     /region_name="NET-5_like_LEL"
                     /note="Tetraspanin, extracellular domain or large
                     extracellular loop (LEL), NET-5_like family. Tetraspanins
                     are trans-membrane proteins with 4 trans-membrane
                     segments. Both the N- and C-termini lie on the
                     intracellular side of the membrane. This alignment
                     model...; cd03165"
                     /db_xref="CDD:239418"
     Site            order(42,47,51,53..54,57,73,76..77,80..81)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:239418"
     CDS             1..175
                     /gene="TSPAN9"
                     /gene_synonym="NET-5; NET5; PP1057"
                     /coded_by="XM_054370838.1:1648..2175"
                     /db_xref="GeneID:10867"
                     /db_xref="HGNC:HGNC:21640"
                     /db_xref="MIM:613137"
ORIGIN      
        1 mvtgflgclg aikenkclll sffivllvil laelillilf fvymdkvnen akkdlkegll
       61 lyhtennvgl knawniiqae mrccgvtdyt dwypvlgent vpdrccmens qgcgrnattp
      121 lwrtgcyekv kmwfddnkhv lgtvgmcili mqilgmafsm tlfqhihrtg kkyda
//
LOCUS       XP_054226814             136 aa            linear   PRI 05-AUG-2025
DEFINITION  tetraspanin-9 isoform X4 [Homo sapiens].
ACCESSION   XP_054226814
VERSION     XP_054226814.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370839.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..136
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..136
                     /product="tetraspanin-9 isoform X4"
                     /calculated_mol_wt=15074
     CDS             1..136
                     /gene="TSPAN9"
                     /gene_synonym="NET-5; NET5; PP1057"
                     /coded_by="XM_054370839.1:9..419"
                     /db_xref="GeneID:10867"
                     /db_xref="HGNC:HGNC:21640"
                     /db_xref="MIM:613137"
ORIGIN      
        1 meksssedss ihrspsldsk dsdfakpsts grpfgrgfta gafygtagsr gqsraeagvk
       61 tdkcnapkgs kyvvfyldls fvfllefkkc nmargclccl kymmflfnli fwnwrhrlls
      121 clpcpsclsl ygcene
//
LOCUS       XP_054226815             740 aa            linear   PRI 05-AUG-2025
DEFINITION  protein OS-9 isoform X1 [Homo sapiens].
ACCESSION   XP_054226815
VERSION     XP_054226815.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370840.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..740
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..740
                     /product="protein OS-9 isoform X1"
                     /calculated_mol_wt=83398
     Region          110..181
                     /region_name="PRKCSH"
                     /note="Glucosidase II beta subunit-like protein;
                     pfam07915"
                     /db_xref="CDD:400321"
     CDS             1..740
                     /gene="OS9"
                     /gene_synonym="ERLEC2; OS-9"
                     /coded_by="XM_054370840.1:31..2253"
                     /db_xref="GeneID:10956"
                     /db_xref="HGNC:HGNC:16994"
                     /db_xref="MIM:609677"
ORIGIN      
        1 maaetllssl lgllllglll pasltggvgs lnleelsemr ygieilplpv mggqsqssdv
       61 vivsskykqr yecrlpagai hfqrereeet payqgpgipe llspmrdapc llktkdwwty
      121 efcygrhiqq yhmedseikg evlylgyyqs afdwddetak askqhrlkry hsqtygngsk
      181 cdlngrprea evrflcdega gisgdyidrv deplscsyvl tirtprlcph pllrpppsaa
      241 pqailchpsl qpeeymayvq rqadskqygd kiieelqdlg pqvwsetksg vapqkmagrt
      301 lfhlfrethf hffpspdltv ltdwwggggv ekyhgpsslg drggegtpsy llpsvsplls
      361 dqslpvlctl gasptkddsk dsdfwkmlne pedqapggee vpaeeqdpsp eaadsasgap
      421 ndfqnnvqvk virspadlir fieelkggtk kgkpnigqeq pvddaaevpq repekergdp
      481 erqremeeee dedededede derqllgefe kelegillps drdrlrsevk agmereleni
      541 iqetekeldp dglkkeserd ramlaltstl nklikrleek qspelvkkhk kkrvvpkkpp
      601 pspqpteedp ehrvrvrvtk lrlggpnqdl tvlemkrenp qlkqieglvk ellereglta
      661 agkieikivr pwaegteega rwltdedtrn lkeiffnilv pgaeeaqker qrqkelesny
      721 rrvwgspgge gtgdldefdf
//
LOCUS       XP_054226816             164 aa            linear   PRI 05-AUG-2025
DEFINITION  glioma pathogenesis-related protein 1 isoform X1 [Homo sapiens].
ACCESSION   XP_054226816
VERSION     XP_054226816.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370841.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..164
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..164
                     /product="glioma pathogenesis-related protein 1 isoform
                     X1"
                     /calculated_mol_wt=18703
     Region          32..>141
                     /region_name="CAP"
                     /note="CAP (cysteine-rich secretory proteins, antigen 5,
                     and pathogenesis-related 1 proteins) domain family;
                     cl00133"
                     /db_xref="CDD:412178"
     CDS             1..164
                     /gene="GLIPR1"
                     /gene_synonym="CRISP7; GLIPR; RTVP1"
                     /coded_by="XM_054370841.1:127..621"
                     /db_xref="GeneID:11010"
                     /db_xref="HGNC:HGNC:17001"
                     /db_xref="MIM:602692"
ORIGIN      
        1 mrvtlatiaw mvsfvsnysh tanilpdien edfikdcvri hnkfrsevkp tasdmlymtw
       61 dpalaqiaka wasncqfshn trlkpphklh pnftslgeni wtgsvpifsv ssaitnwyde
      121 iqdydfktri ckkvcghytq vsqergrdpn pkrgflnlar enpg
//
LOCUS       XP_054226817             589 aa            linear   PRI 05-AUG-2025
DEFINITION  cleavage and polyadenylation specificity factor subunit 6 isoform
            X1 [Homo sapiens].
ACCESSION   XP_054226817
VERSION     XP_054226817.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370842.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..589
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..589
                     /product="cleavage and polyadenylation specificity factor
                     subunit 6 isoform X1"
                     /calculated_mol_wt=63496
     Region          82..158
                     /region_name="RRM_CFIm68"
                     /note="RNA recognition motif (RRM) found in pre-mRNA
                     cleavage factor Im 68 kDa subunit (CFIm68 or CPSF6) and
                     similar proteins; cd12643"
                     /db_xref="CDD:410048"
     Site            order(90..95,113,116..123)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410048"
     CDS             1..589
                     /gene="CPSF6"
                     /gene_synonym="CFIM; CFIM68; CFIM72; HPBRII-4; HPBRII-7"
                     /coded_by="XM_054370842.1:79..1848"
                     /db_xref="GeneID:11052"
                     /db_xref="HGNC:HGNC:13871"
                     /db_xref="MIM:604979"
ORIGIN      
        1 madgvdhidi yadvgeefnq eaeygghdqi dlyddvisps anngdapedr dymdtlpptv
       61 gddvgkgaap nvvytytgkr ialyignltw wttdedltea vhslgvndil eikffenran
      121 gqskgfalvg vgseasskkl mdllpkrelh gqnpvvtpcn kqflsqfemq srkttqsgqm
      181 sgegkagppg gssraafpqg grgrgrfpga vpggdrfpgp agpggppppf pgnlikhlvk
      241 gtrplfletr ipwhmghsie eipifglkag qtpprpplgp pgppgppgpp ppgqvlpppl
      301 agppnrgdrp pppvlfpgqp fgqpplgplp pgppppvpgy gpppgppppq qgpppppgpf
      361 pprppgplgp pltlappphl pgpppgappp aphvnpaffp pptnsgmpts dsrgppptdp
      421 ygrpppydrg dygppgremd tartplseae feeimnrnra isssaisrav sdasagdygs
      481 aietlvtais likqskvsad drckvlissl qdclhgiesk sygsgsrrre rsrerdhsrs
      541 reksrrhksr srdrhddyyr ersrererhr drdrdrdrer drereyrhr
//
LOCUS       XP_054226818             589 aa            linear   PRI 05-AUG-2025
DEFINITION  cleavage and polyadenylation specificity factor subunit 6 isoform
            X1 [Homo sapiens].
ACCESSION   XP_054226818
VERSION     XP_054226818.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370843.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..589
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..589
                     /product="cleavage and polyadenylation specificity factor
                     subunit 6 isoform X1"
                     /calculated_mol_wt=63496
     Region          82..158
                     /region_name="RRM_CFIm68"
                     /note="RNA recognition motif (RRM) found in pre-mRNA
                     cleavage factor Im 68 kDa subunit (CFIm68 or CPSF6) and
                     similar proteins; cd12643"
                     /db_xref="CDD:410048"
     Site            order(90..95,113,116..123)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410048"
     CDS             1..589
                     /gene="CPSF6"
                     /gene_synonym="CFIM; CFIM68; CFIM72; HPBRII-4; HPBRII-7"
                     /coded_by="XM_054370843.1:79..1848"
                     /db_xref="GeneID:11052"
                     /db_xref="HGNC:HGNC:13871"
                     /db_xref="MIM:604979"
ORIGIN      
        1 madgvdhidi yadvgeefnq eaeygghdqi dlyddvisps anngdapedr dymdtlpptv
       61 gddvgkgaap nvvytytgkr ialyignltw wttdedltea vhslgvndil eikffenran
      121 gqskgfalvg vgseasskkl mdllpkrelh gqnpvvtpcn kqflsqfemq srkttqsgqm
      181 sgegkagppg gssraafpqg grgrgrfpga vpggdrfpgp agpggppppf pgnlikhlvk
      241 gtrplfletr ipwhmghsie eipifglkag qtpprpplgp pgppgppgpp ppgqvlpppl
      301 agppnrgdrp pppvlfpgqp fgqpplgplp pgppppvpgy gpppgppppq qgpppppgpf
      361 pprppgplgp pltlappphl pgpppgappp aphvnpaffp pptnsgmpts dsrgppptdp
      421 ygrpppydrg dygppgremd tartplseae feeimnrnra isssaisrav sdasagdygs
      481 aietlvtais likqskvsad drckvlissl qdclhgiesk sygsgsrrre rsrerdhsrs
      541 reksrrhksr srdrhddyyr ersrererhr drdrdrdrer drereyrhr
//
LOCUS       XP_054226819             552 aa            linear   PRI 05-AUG-2025
DEFINITION  cleavage and polyadenylation specificity factor subunit 6 isoform
            X2 [Homo sapiens].
ACCESSION   XP_054226819
VERSION     XP_054226819.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370844.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..552
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..552
                     /product="cleavage and polyadenylation specificity factor
                     subunit 6 isoform X2"
                     /calculated_mol_wt=59235
     Region          82..158
                     /region_name="RRM_CFIm68"
                     /note="RNA recognition motif (RRM) found in pre-mRNA
                     cleavage factor Im 68 kDa subunit (CFIm68 or CPSF6) and
                     similar proteins; cd12643"
                     /db_xref="CDD:410048"
     Site            order(90..95,113,116..123)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410048"
     CDS             1..552
                     /gene="CPSF6"
                     /gene_synonym="CFIM; CFIM68; CFIM72; HPBRII-4; HPBRII-7"
                     /coded_by="XM_054370844.1:79..1737"
                     /db_xref="GeneID:11052"
                     /db_xref="HGNC:HGNC:13871"
                     /db_xref="MIM:604979"
ORIGIN      
        1 madgvdhidi yadvgeefnq eaeygghdqi dlyddvisps anngdapedr dymdtlpptv
       61 gddvgkgaap nvvytytgkr ialyignltw wttdedltea vhslgvndil eikffenran
      121 gqskgfalvg vgseasskkl mdllpkrelh gqnpvvtpcn kqflsqfemq srkttqsgqm
      181 sgegkagppg gssraafpqg grgrgrfpga vpggdrfpgp agpggppppf pagqtpprpp
      241 lgppgppgpp gppppgqvlp pplagppnrg drppppvlfp gqpfgqpplg plppgppppv
      301 pgygpppgpp ppqqgppppp gpfpprppgp lgppltlapp phlpgpppga pppaphvnpa
      361 ffppptnsgm ptsdsrgppp tdpygrpppy drgdygppgr emdtartpls eaefeeimnr
      421 nraisssais ravsdasagd ygsaietlvt aislikqskv saddrckvli sslqdclhgi
      481 esksygsgsr rrersrerdh srsreksrrh ksrsrdrhdd yyrersrere rhrdrdrdrd
      541 rerdrereyr hr
//
LOCUS       XP_054226821             808 aa            linear   PRI 05-AUG-2025
DEFINITION  PR domain zinc finger protein 4 isoform X1 [Homo sapiens].
ACCESSION   XP_054226821
VERSION     XP_054226821.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370846.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..808
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..808
                     /product="PR domain zinc finger protein 4 isoform X1"
                     /calculated_mol_wt=88469
     Region          365..402
                     /region_name="zf_PR_Knuckle"
                     /note="PR zinc knuckle motif; pfam18445"
                     /db_xref="CDD:375871"
     Region          405..544
                     /region_name="PR-SET_PRDM4"
                     /note="PR-SET domain found in PR domain zinc finger
                     protein 4 (PRDM4) and similar proteins; cd19189"
                     /db_xref="CDD:380966"
     Site            order(423..425,449,469..472,482,495..499,501,510..511,
                     535..536)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:380966"
     Site            order(423..425,469,495..499,501,535)
                     /site_type="other"
                     /note="putative SAM binding site"
                     /db_xref="CDD:380966"
     Region          554..591
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          599..619
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          627..647
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(632,634,636,638..639,642..643,646,660,662,666..667,
                     670..671,674,688,690,692,694..695,698..699,702)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          639..664
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          655..675
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          667..690
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          683..703
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          695..720
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          711..731
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          739..758
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..808
                     /gene="PRDM4"
                     /gene_synonym="PFM1"
                     /coded_by="XM_054370846.1:399..2825"
                     /db_xref="GeneID:11108"
                     /db_xref="HGNC:HGNC:9348"
                     /db_xref="MIM:605780"
ORIGIN      
        1 mhhrmnemnl spvgmeqlts ssvsnalpvs gshlglaasp thsaipapgl pvaipnlgps
       61 lsslpsalsl mlpmgigdrg vmcglperny tlppppyphl essyfrtilp gilsyladrp
      121 ppqyihpnsi nvdgntalsi tnnpsaldpy qsngnvglep givsidsrsv nthgaqslhp
      181 sdghevaldt aitmenvsrv tspistdgma eeltmdgvag ehsqipngsr sheplsvdsv
      241 snnlaadavg hggvipmhgn glelpvvmet dhiasrvngm sdsalsdsih tvamstnsvs
      301 valstshnla slesvslhev glslepvavs sitqevamgt ghvdvssdsl sfvspslqme
      361 dsnsnkenma tlftiwctlc draypsdcpe hgpvtfvpdt piesrarlsl pkqlvlrqsi
      421 vgaevvgvlp ltgvwtgeti pvrtcfgpli gqqshsmeva ewtdkavnhi wkiyhngvle
      481 fciittdene cnwmmfvrka rnreeqnlva yphdgkiffc tsqdippene llfyysrdya
      541 qqigvpehpd vhlcncgkec nsytefkahl tshihnhlpt qghsgshgps hskerkwkcs
      601 mcpqafisps klhvhfmghm gmkphkcdfc skafsdpsnl rthlkihtgq knyrctlcdk
      661 sftqkahles hmvihtgekn lkcdycdklf mrrqdlkqhv lihtqerqik cpkcdklflr
      721 tnhlkkhlns hegkrdyvce kctkayltky hltrhlktck gptssssape eeeeddseee
      781 dladsvgted crinsavysa deslsahk
//
LOCUS       XP_054226822             801 aa            linear   PRI 05-AUG-2025
DEFINITION  PR domain zinc finger protein 4 isoform X2 [Homo sapiens].
ACCESSION   XP_054226822
VERSION     XP_054226822.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370847.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..801
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..801
                     /product="PR domain zinc finger protein 4 isoform X2"
                     /calculated_mol_wt=87789
     Region          365..402
                     /region_name="zf_PR_Knuckle"
                     /note="PR zinc knuckle motif; pfam18445"
                     /db_xref="CDD:375871"
     Region          405..537
                     /region_name="PR-SET_PRDM4"
                     /note="PR-SET domain found in PR domain zinc finger
                     protein 4 (PRDM4) and similar proteins; cd19189"
                     /db_xref="CDD:380966"
     Site            order(423..425,442,462..465,475,488..492,494,503..504,
                     528..529)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:380966"
     Site            order(423..425,462,488..492,494,528)
                     /site_type="other"
                     /note="putative SAM binding site"
                     /db_xref="CDD:380966"
     Region          547..584
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          592..612
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          620..640
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(625,627,629,631..632,635..636,639,653,655,659..660,
                     663..664,667,681,683,685,687..688,691..692,695)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          632..657
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          648..668
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          660..683
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          676..696
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          688..713
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          704..724
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          732..751
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..801
                     /gene="PRDM4"
                     /gene_synonym="PFM1"
                     /coded_by="XM_054370847.1:424..2829"
                     /db_xref="GeneID:11108"
                     /db_xref="HGNC:HGNC:9348"
                     /db_xref="MIM:605780"
ORIGIN      
        1 mhhrmnemnl spvgmeqlts ssvsnalpvs gshlglaasp thsaipapgl pvaipnlgps
       61 lsslpsalsl mlpmgigdrg vmcglperny tlppppyphl essyfrtilp gilsyladrp
      121 ppqyihpnsi nvdgntalsi tnnpsaldpy qsngnvglep givsidsrsv nthgaqslhp
      181 sdghevaldt aitmenvsrv tspistdgma eeltmdgvag ehsqipngsr sheplsvdsv
      241 snnlaadavg hggvipmhgn glelpvvmet dhiasrvngm sdsalsdsih tvamstnsvs
      301 valstshnla slesvslhev glslepvavs sitqevamgt ghvdvssdsl sfvspslqme
      361 dsnsnkenma tlftiwctlc draypsdcpe hgpvtfvpdt piesrarlsl pkqlvlrqsi
      421 vgaevgvwtg etipvrtcfg pligqqshsm evaewtdkav nhiwkiyhng vlefciittd
      481 enecnwmmfv rkarnreeqn lvayphdgki ffctsqdipp enellfyysr dyaqqigvpe
      541 hpdvhlcncg kecnsytefk ahltshihnh lptqghsgsh gpshskerkw kcsmcpqafi
      601 spsklhvhfm ghmgmkphkc dfcskafsdp snlrthlkih tgqknyrctl cdksftqkah
      661 leshmvihtg eknlkcdycd klfmrrqdlk qhvlihtqer qikcpkcdkl flrtnhlkkh
      721 lnshegkrdy vcekctkayl tkyhltrhlk tckgptssss apeeeeedds eeedladsvg
      781 tedcrinsav ysadeslsah k
//
LOCUS       XP_054226833            1638 aa            linear   PRI 05-AUG-2025
DEFINITION  citron Rho-interacting kinase isoform X11 [Homo sapiens].
ACCESSION   XP_054226833
VERSION     XP_054226833.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370858.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1638
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1638
                     /product="citron Rho-interacting kinase isoform X11"
                     /calculated_mol_wt=188108
     Region          1..>152
                     /region_name="CwlO1"
                     /note="Uncharacterized N-terminal coiled-coil domain of
                     peptidoglycan hydrolase CwlO [Function unknown]; COG3883"
                     /db_xref="CDD:443091"
     Region          85..897
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          955..1010
                     /region_name="CRIK"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in citron Rho-interacting kinase (CRIK) and similar
                     proteins; cd20814"
                     /db_xref="CDD:410364"
     Region          1040..1159
                     /region_name="PH"
                     /note="PH domain; pfam00169"
                     /db_xref="CDD:459697"
     Region          1204..1500
                     /region_name="CNH"
                     /note="Domain found in NIK1-like kinases, mouse citron and
                     yeast ROM1, ROM2; smart00036"
                     /db_xref="CDD:214481"
     Region          <1516..>1605
                     /region_name="PTZ00449"
                     /note="104 kDa microneme/rhoptry antigen; Provisional"
                     /db_xref="CDD:185628"
     CDS             1..1638
                     /gene="CIT"
                     /gene_synonym="CITK; CRIK; MCPH17; STK21"
                     /coded_by="XM_054370858.1:521..5437"
                     /db_xref="GeneID:11113"
                     /db_xref="HGNC:HGNC:1985"
                     /db_xref="MIM:605629"
ORIGIN      
        1 mekklliksk elqdsqdkch kmeqemtrlh rrvseveavl sqkevelkas etqrslleqd
       61 latyitecss lkrsleqarm evsqeddkal qllhdireqs rklqeikeqe yqaqveemrl
      121 mmnqleedlv sarrrsdlye selresrlaa eefkrkatec qhkllkakdq gkpevgeyak
      181 lekinaeqql kiqelqekle kavkasteat ellqnirqak eraerelekl qnredssegi
      241 rkklveaeer rhslenkvkr letmerrenr lkddiqtksq qiqqmadkil eleekhreaq
      301 vsaqhlevhl kqkeqhyeek ikvldnqikk dladketlen mmqrheeeah ekgkilseqk
      361 aminamdski rsleqrivel seanklaans slftqrnmka qeemiselrq qkfyletqag
      421 kleaqnrkle eqlekishqd hsdknrllel etrlrevsle heeqklelkr qltelqlslq
      481 eresqltalq aaraalesql rqakteleet taeaeeeiqa ltahrdeiqr kfdalrnsct
      541 vitdleeqln qltednaeln nqnfylskql deasgandei vqlrsevdhl rreiteremq
      601 ltsqkqtmea lkttctmlee qvmdlealnd ellekerqwe awrsvlgdek sqfecrvrel
      661 qrmldtekqs raradqrite srqvvelavk ehkaeilalq qalkeqklka eslsdklndl
      721 ekkhamlemn arslqqklet erelkqrlle eqaklqqqmd lqknhifrlt qglqealdra
      781 dllktersdl eyqleniqvl yshekvkmeg tisqqtklid flqakmdqpa kkkkglfsrr
      841 kedpalptqv plqynelkla lekekarcae leealqktri elrsareeaa hrkatdhphp
      901 stpatarqqi amsaivrspe hqpsamslla ppssrrkess tpeefsrrlk ermhhniphr
      961 fnvglnmrat kcavcldtvh fgrqaskcle cqvmchpkcs tclpatcglp aeyathftea
     1021 fcrdkmnspg lqtkepsssl hlegwmkvpr nnkrgqqgwd rkyivlegsk vliydneare
     1081 agqrpveefe lclpdgdvsi hgavgasela ntakadvpyi lkmeshphtt cwpgrtlyll
     1141 apsfpdkqrw vtalesvvag grvsrekaea daardcvsye llpawvqkll gnsllklegd
     1201 drldmnctlp fsdqvvlvgt eeglyalnvl knslthvpgi gavfqiyiik dlekllmiag
     1261 eeralclvdv kkvkqslaqs hlpaqpdisp nifeavkgch lfgagkieng lcicaampsk
     1321 vvilrynenl skycirkeie tsepcscihf tnysiligtn kfyeidmkqy tleefldknd
     1381 hslapavfaa ssnsfpvsiv qvnsagqree yllcfhefgv fvdsygrrsr tddlkwsrlp
     1441 lafayrepyl fvthfnslev ieiqarssag tparayldip nprylgpais sgaiylassy
     1501 qdklrvicck gnlvkesgte hhrgpstsrs spnkrgppty nehitkrvas spappegpsh
     1561 prepstphry regrtelrrd kspgrplere kspgrmlstr rerspgrlfe dssrgrlpag
     1621 avrtplsqvn kvwdqssv
//
LOCUS       XP_054226834            1638 aa            linear   PRI 05-AUG-2025
DEFINITION  citron Rho-interacting kinase isoform X11 [Homo sapiens].
ACCESSION   XP_054226834
VERSION     XP_054226834.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370859.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1638
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1638
                     /product="citron Rho-interacting kinase isoform X11"
                     /calculated_mol_wt=188108
     Region          1..>152
                     /region_name="CwlO1"
                     /note="Uncharacterized N-terminal coiled-coil domain of
                     peptidoglycan hydrolase CwlO [Function unknown]; COG3883"
                     /db_xref="CDD:443091"
     Region          85..897
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          955..1010
                     /region_name="CRIK"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in citron Rho-interacting kinase (CRIK) and similar
                     proteins; cd20814"
                     /db_xref="CDD:410364"
     Region          1040..1159
                     /region_name="PH"
                     /note="PH domain; pfam00169"
                     /db_xref="CDD:459697"
     Region          1204..1500
                     /region_name="CNH"
                     /note="Domain found in NIK1-like kinases, mouse citron and
                     yeast ROM1, ROM2; smart00036"
                     /db_xref="CDD:214481"
     Region          <1516..>1605
                     /region_name="PTZ00449"
                     /note="104 kDa microneme/rhoptry antigen; Provisional"
                     /db_xref="CDD:185628"
     CDS             1..1638
                     /gene="CIT"
                     /gene_synonym="CITK; CRIK; MCPH17; STK21"
                     /coded_by="XM_054370859.1:125..5041"
                     /db_xref="GeneID:11113"
                     /db_xref="HGNC:HGNC:1985"
                     /db_xref="MIM:605629"
ORIGIN      
        1 mekklliksk elqdsqdkch kmeqemtrlh rrvseveavl sqkevelkas etqrslleqd
       61 latyitecss lkrsleqarm evsqeddkal qllhdireqs rklqeikeqe yqaqveemrl
      121 mmnqleedlv sarrrsdlye selresrlaa eefkrkatec qhkllkakdq gkpevgeyak
      181 lekinaeqql kiqelqekle kavkasteat ellqnirqak eraerelekl qnredssegi
      241 rkklveaeer rhslenkvkr letmerrenr lkddiqtksq qiqqmadkil eleekhreaq
      301 vsaqhlevhl kqkeqhyeek ikvldnqikk dladketlen mmqrheeeah ekgkilseqk
      361 aminamdski rsleqrivel seanklaans slftqrnmka qeemiselrq qkfyletqag
      421 kleaqnrkle eqlekishqd hsdknrllel etrlrevsle heeqklelkr qltelqlslq
      481 eresqltalq aaraalesql rqakteleet taeaeeeiqa ltahrdeiqr kfdalrnsct
      541 vitdleeqln qltednaeln nqnfylskql deasgandei vqlrsevdhl rreiteremq
      601 ltsqkqtmea lkttctmlee qvmdlealnd ellekerqwe awrsvlgdek sqfecrvrel
      661 qrmldtekqs raradqrite srqvvelavk ehkaeilalq qalkeqklka eslsdklndl
      721 ekkhamlemn arslqqklet erelkqrlle eqaklqqqmd lqknhifrlt qglqealdra
      781 dllktersdl eyqleniqvl yshekvkmeg tisqqtklid flqakmdqpa kkkkglfsrr
      841 kedpalptqv plqynelkla lekekarcae leealqktri elrsareeaa hrkatdhphp
      901 stpatarqqi amsaivrspe hqpsamslla ppssrrkess tpeefsrrlk ermhhniphr
      961 fnvglnmrat kcavcldtvh fgrqaskcle cqvmchpkcs tclpatcglp aeyathftea
     1021 fcrdkmnspg lqtkepsssl hlegwmkvpr nnkrgqqgwd rkyivlegsk vliydneare
     1081 agqrpveefe lclpdgdvsi hgavgasela ntakadvpyi lkmeshphtt cwpgrtlyll
     1141 apsfpdkqrw vtalesvvag grvsrekaea daardcvsye llpawvqkll gnsllklegd
     1201 drldmnctlp fsdqvvlvgt eeglyalnvl knslthvpgi gavfqiyiik dlekllmiag
     1261 eeralclvdv kkvkqslaqs hlpaqpdisp nifeavkgch lfgagkieng lcicaampsk
     1321 vvilrynenl skycirkeie tsepcscihf tnysiligtn kfyeidmkqy tleefldknd
     1381 hslapavfaa ssnsfpvsiv qvnsagqree yllcfhefgv fvdsygrrsr tddlkwsrlp
     1441 lafayrepyl fvthfnslev ieiqarssag tparayldip nprylgpais sgaiylassy
     1501 qdklrvicck gnlvkesgte hhrgpstsrs spnkrgppty nehitkrvas spappegpsh
     1561 prepstphry regrtelrrd kspgrplere kspgrmlstr rerspgrlfe dssrgrlpag
     1621 avrtplsqvn kvwdqssv
//
LOCUS       XP_054226835            1618 aa            linear   PRI 05-AUG-2025
DEFINITION  citron Rho-interacting kinase isoform X12 [Homo sapiens].
ACCESSION   XP_054226835
VERSION     XP_054226835.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370860.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1618
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1618
                     /product="citron Rho-interacting kinase isoform X12"
                     /calculated_mol_wt=185728
     Region          65..877
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          935..990
                     /region_name="CRIK"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in citron Rho-interacting kinase (CRIK) and similar
                     proteins; cd20814"
                     /db_xref="CDD:410364"
     Region          1020..1139
                     /region_name="PH"
                     /note="PH domain; pfam00169"
                     /db_xref="CDD:459697"
     Region          1184..1480
                     /region_name="CNH"
                     /note="Domain found in NIK1-like kinases, mouse citron and
                     yeast ROM1, ROM2; smart00036"
                     /db_xref="CDD:214481"
     Region          <1496..>1585
                     /region_name="PTZ00449"
                     /note="104 kDa microneme/rhoptry antigen; Provisional"
                     /db_xref="CDD:185628"
     CDS             1..1618
                     /gene="CIT"
                     /gene_synonym="CITK; CRIK; MCPH17; STK21"
                     /coded_by="XM_054370860.1:655..5511"
                     /db_xref="GeneID:11113"
                     /db_xref="HGNC:HGNC:1985"
                     /db_xref="MIM:605629"
ORIGIN      
        1 mmeqemtrlh rrvseveavl sqkevelkas etqrslleqd latyitecss lkrsleqarm
       61 evsqeddkal qllhdireqs rklqeikeqe yqaqveemrl mmnqleedlv sarrrsdlye
      121 selresrlaa eefkrkatec qhkllkakdq gkpevgeyak lekinaeqql kiqelqekle
      181 kavkasteat ellqnirqak eraerelekl qnredssegi rkklveaeer rhslenkvkr
      241 letmerrenr lkddiqtksq qiqqmadkil eleekhreaq vsaqhlevhl kqkeqhyeek
      301 ikvldnqikk dladketlen mmqrheeeah ekgkilseqk aminamdski rsleqrivel
      361 seanklaans slftqrnmka qeemiselrq qkfyletqag kleaqnrkle eqlekishqd
      421 hsdknrllel etrlrevsle heeqklelkr qltelqlslq eresqltalq aaraalesql
      481 rqakteleet taeaeeeiqa ltahrdeiqr kfdalrnsct vitdleeqln qltednaeln
      541 nqnfylskql deasgandei vqlrsevdhl rreiteremq ltsqkqtmea lkttctmlee
      601 qvmdlealnd ellekerqwe awrsvlgdek sqfecrvrel qrmldtekqs raradqrite
      661 srqvvelavk ehkaeilalq qalkeqklka eslsdklndl ekkhamlemn arslqqklet
      721 erelkqrlle eqaklqqqmd lqknhifrlt qglqealdra dllktersdl eyqleniqvl
      781 yshekvkmeg tisqqtklid flqakmdqpa kkkkglfsrr kedpalptqv plqynelkla
      841 lekekarcae leealqktri elrsareeaa hrkatdhphp stpatarqqi amsaivrspe
      901 hqpsamslla ppssrrkess tpeefsrrlk ermhhniphr fnvglnmrat kcavcldtvh
      961 fgrqaskcle cqvmchpkcs tclpatcglp aeyathftea fcrdkmnspg lqtkepsssl
     1021 hlegwmkvpr nnkrgqqgwd rkyivlegsk vliydneare agqrpveefe lclpdgdvsi
     1081 hgavgasela ntakadvpyi lkmeshphtt cwpgrtlyll apsfpdkqrw vtalesvvag
     1141 grvsrekaea daardcvsye llpawvqkll gnsllklegd drldmnctlp fsdqvvlvgt
     1201 eeglyalnvl knslthvpgi gavfqiyiik dlekllmiag eeralclvdv kkvkqslaqs
     1261 hlpaqpdisp nifeavkgch lfgagkieng lcicaampsk vvilrynenl skycirkeie
     1321 tsepcscihf tnysiligtn kfyeidmkqy tleefldknd hslapavfaa ssnsfpvsiv
     1381 qvnsagqree yllcfhefgv fvdsygrrsr tddlkwsrlp lafayrepyl fvthfnslev
     1441 ieiqarssag tparayldip nprylgpais sgaiylassy qdklrvicck gnlvkesgte
     1501 hhrgpstsrs spnkrgppty nehitkrvas spappegpsh prepstphry regrtelrrd
     1561 kspgrplere kspgrmlstr rerspgrlfe dssrgrlpag avrtplsqvn kvwdqssv
//
LOCUS       XP_054226836             129 aa            linear   PRI 05-AUG-2025
DEFINITION  diphosphoinositol polyphosphate phosphohydrolase 2 isoform X1 [Homo
            sapiens].
ACCESSION   XP_054226836
VERSION     XP_054226836.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370861.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..129
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..129
                     /product="diphosphoinositol polyphosphate phosphohydrolase
                     2 isoform X1"
                     /calculated_mol_wt=14264
     Region          <1..92
                     /region_name="NUDIX_DIPP2_like_Nudt4"
                     /note="diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase
                     type 2 and similar proteins; cd04666"
                     /db_xref="CDD:467551"
     CDS             1..129
                     /gene="NUDT4"
                     /gene_synonym="DIPP-2B; DIPP2; DIPP2alpha; DIPP2beta;
                     HDCMB47P; NUDT4B"
                     /coded_by="XM_054370861.1:174..563"
                     /db_xref="GeneID:11163"
                     /db_xref="HGNC:HGNC:8051"
                     /db_xref="MIM:609229"
ORIGIN      
        1 mepeeepgga avrevyeeag vkgklgrllg ifeqnqdrkh rtyvyvltvt eiledwedsv
       61 nigrkrewfk vedaikvlqc hkpvhaeyle klklgcspan gnstvpslpd nnalfvtaaq
      121 tsglpssvr
//
LOCUS       XP_054226837             129 aa            linear   PRI 05-AUG-2025
DEFINITION  diphosphoinositol polyphosphate phosphohydrolase 2 isoform X1 [Homo
            sapiens].
ACCESSION   XP_054226837
VERSION     XP_054226837.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370862.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 29% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..129
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..129
                     /product="diphosphoinositol polyphosphate phosphohydrolase
                     2 isoform X1"
                     /calculated_mol_wt=14264
     Region          <1..92
                     /region_name="NUDIX_DIPP2_like_Nudt4"
                     /note="diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase
                     type 2 and similar proteins; cd04666"
                     /db_xref="CDD:467551"
     CDS             1..129
                     /gene="NUDT4"
                     /gene_synonym="DIPP-2B; DIPP2; DIPP2alpha; DIPP2beta;
                     HDCMB47P; NUDT4B"
                     /coded_by="XM_054370862.1:315..704"
                     /db_xref="GeneID:11163"
                     /db_xref="HGNC:HGNC:8051"
                     /db_xref="MIM:609229"
ORIGIN      
        1 mepeeepgga avrevyeeag vkgklgrllg ifeqnqdrkh rtyvyvltvt eiledwedsv
       61 nigrkrewfk vedaikvlqc hkpvhaeyle klklgcspan gnstvpslpd nnalfvtaaq
      121 tsglpssvr
//
LOCUS       XP_054226838             129 aa            linear   PRI 05-AUG-2025
DEFINITION  diphosphoinositol polyphosphate phosphohydrolase 2 isoform X1 [Homo
            sapiens].
ACCESSION   XP_054226838
VERSION     XP_054226838.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370863.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..129
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..129
                     /product="diphosphoinositol polyphosphate phosphohydrolase
                     2 isoform X1"
                     /calculated_mol_wt=14264
     Region          <1..92
                     /region_name="NUDIX_DIPP2_like_Nudt4"
                     /note="diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase
                     type 2 and similar proteins; cd04666"
                     /db_xref="CDD:467551"
     CDS             1..129
                     /gene="NUDT4"
                     /gene_synonym="DIPP-2B; DIPP2; DIPP2alpha; DIPP2beta;
                     HDCMB47P; NUDT4B"
                     /coded_by="XM_054370863.1:218..607"
                     /db_xref="GeneID:11163"
                     /db_xref="HGNC:HGNC:8051"
                     /db_xref="MIM:609229"
ORIGIN      
        1 mepeeepgga avrevyeeag vkgklgrllg ifeqnqdrkh rtyvyvltvt eiledwedsv
       61 nigrkrewfk vedaikvlqc hkpvhaeyle klklgcspan gnstvpslpd nnalfvtaaq
      121 tsglpssvr
//
LOCUS       XP_054226839             128 aa            linear   PRI 05-AUG-2025
DEFINITION  diphosphoinositol polyphosphate phosphohydrolase 2 isoform X2 [Homo
            sapiens].
ACCESSION   XP_054226839
VERSION     XP_054226839.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370864.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..128
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..128
                     /product="diphosphoinositol polyphosphate phosphohydrolase
                     2 isoform X2"
                     /calculated_mol_wt=14136
     Region          <1..91
                     /region_name="NUDIX_DIPP2_like_Nudt4"
                     /note="diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase
                     type 2 and similar proteins; cd04666"
                     /db_xref="CDD:467551"
     CDS             1..128
                     /gene="NUDT4"
                     /gene_synonym="DIPP-2B; DIPP2; DIPP2alpha; DIPP2beta;
                     HDCMB47P; NUDT4B"
                     /coded_by="XM_054370864.1:97..483"
                     /db_xref="GeneID:11163"
                     /db_xref="HGNC:HGNC:8051"
                     /db_xref="MIM:609229"
ORIGIN      
        1 mepeeepgga avrevyeeag vkgklgrllg ifenqdrkhr tyvyvltvte iledwedsvn
       61 igrkrewfkv edaikvlqch kpvhaeylek lklgcspang nstvpslpdn nalfvtaaqt
      121 sglpssvr
//
LOCUS       XP_054226840            1912 aa            linear   PRI 05-AUG-2025
DEFINITION  bromodomain adjacent to zinc finger domain protein 2A isoform X23
            [Homo sapiens].
ACCESSION   XP_054226840
VERSION     XP_054226840.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370865.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1912
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1912
                     /product="bromodomain adjacent to zinc finger domain
                     protein 2A isoform X23"
                     /calculated_mol_wt=211792
     Region          <392..>524
                     /region_name="PRK10856"
                     /note="cytoskeleton protein RodZ"
                     /db_xref="CDD:236776"
     Region          551..623
                     /region_name="HAT_MBD"
                     /note="Methyl-CpG binding domains (MBD) present in
                     putative chromatin remodelling factor such as BAZ2A; BAZ2A
                     contains a MBD, DDT, PHD-type zinc finger and Bromo domain
                     suggesting that BAZ2A might be associated with histone
                     acetyltransferase (HAT) activity. The...; cd01397"
                     /db_xref="CDD:238691"
     Site            order(563,565,567,574,576,585,588,592)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238691"
     Region          848..913
                     /region_name="DDT"
                     /note="domain in different transcription and chromosome
                     remodeling factors; smart00571"
                     /db_xref="CDD:214726"
     Region          1111..>1166
                     /region_name="WSD"
                     /note="Williams-Beuren syndrome DDT (WSD), D-TOX E motif;
                     pfam15613"
                     /db_xref="CDD:464775"
     Region          <1327..1430
                     /region_name="PHA03378"
                     /note="EBNA-3B; Provisional"
                     /db_xref="CDD:223065"
     Region          <1439..1473
                     /region_name="WSD"
                     /note="Williams-Beuren syndrome DDT (WSD), D-TOX E motif;
                     pfam15613"
                     /db_xref="CDD:464775"
     Region          1685..1731
                     /region_name="PHD_BAZ2A"
                     /note="PHD finger found in bromodomain adjacent to zinc
                     finger domain protein 2A (BAZ2A); cd15629"
                     /db_xref="CDD:277099"
     Site            order(1692,1695..1696,1698..1702,1720..1723)
                     /site_type="other"
                     /note="H3 histone binding site [polypeptide binding]"
                     /db_xref="CDD:277099"
     Region          1805..1901
                     /region_name="Bromo_BAZ2A_B_like"
                     /note="Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo
                     adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were
                     identified as a novel human bromodomain gene by cDNA
                     library screening. BAZ2A is also known as Tip5
                     (Transcription termination factor I-interacting...;
                     cd05503"
                     /db_xref="CDD:99935"
     Site            order(1829,1834,1837,1876,1880,1886)
                     /site_type="active"
                     /note="acetyllysine binding site [active]"
                     /db_xref="CDD:99935"
     CDS             1..1912
                     /gene="BAZ2A"
                     /gene_synonym="TIP5; WALp3"
                     /coded_by="XM_054370865.1:175..5913"
                     /db_xref="GeneID:11176"
                     /db_xref="HGNC:HGNC:962"
                     /db_xref="MIM:605682"
ORIGIN      
        1 memeandhfn ftglppapaa sglkpspssg eglytngspm nfpqqgksln gdvnvnglst
       61 vshtttsgil nsaphsssts hlhhpsvayd clwnysqyps anpgsnlkdp pllsqfsggq
      121 yplngilggs rqpsspshnt nlragsqefw angtqspmgl nfdsqelyds fpdqnfevmp
      181 ngppsfftsp qtspmlgssi qtfapsqevg sgihpdeaae kemtsvvaen gtglvgslel
      241 eeeqpelkmc gyngsvpsve slhqevsvlv pdptvscldd pshlpdqled tpilsedsle
      301 pfnslapepv sgglygiddt elmgaedklp ledspvisal dcpslnnata fslladdsqt
      361 stsifaspts ppvlgesvlq dnsfdlnngs daeqeemetq ssdfppsltq papdqsstiq
      421 lhpatspavs pttspavslv vspaaspeis pevcpaastv vspavfsvvs passavlpav
      481 slevpltasv tspkaspvts paaafptasp ankdvssfle ttadveeitg egltasgsgd
      541 vmrrriatpe evrlplqhgw rrevrikkgs hrwqgetwyy gpcgkrmkqf pevikylsrn
      601 vvhsvrrehf sfsprmpvgd ffeerdtpeg lqwvqlsaee ipsriqaitg krgrprntek
      661 aktkevpkvk rgrgrppkvk itellnktdn rplkkleaqe tlneedkaki akskkkmrqk
      721 vqrgecqtti qgqarnkrkq etkslkqkea kkkskaekek gktkqeklke kvkrekkekv
      781 kmkekeevtk akpackadkt latqrrleer qrqqmileem kkptedmclt dhqplpdfsr
      841 vpgltlpsga fsdcltivef lhsfgkvlgf dpakdvpslg vlqegllcqg dslgevqdll
      901 vrllkaalhd pgfpsycqsl kilgekvsei pltrdnvsei lrcflmaygv epalcdrlrt
      961 qpfqaqppqq kaavlaflvh elngstliin eidktlesms syrknkwive grlrrlktvl
     1021 akrtgrseve megpeeclgr rrssrimeet sgmeeeeeee siaavpgrrg rrdgevdata
     1081 ssipelerqi eklskrqlff rkkllhssqm lravslgqdr yrrrywvlpy lagifvegte
     1141 gnlvpeevik ketdslkvaa haslnpalfs mkmelagsnt tasspararg rprktkpgsm
     1201 qprhlkspvr gqdseqpqaq lqpeaqlhap aqpqpqlqlq lqshkgfleq egsplslgqs
     1261 qhdlsqsafl swlsqtqshs sllsssvltp dsspgkldpa psqppeepep deaesspdpq
     1321 alwfnisaqm pcnaaptppp avsedqptps pqqlasskpm nrpsaanpcs pvqfsstpla
     1381 glapkrragd pgempqsptg lgqpkrrgrp pskffkqmeq ryltqltaqp vppemcsgww
     1441 wirdpemlda mlkalhprgi rekalhkhln khrdflqevc lrpsadpife prqlpafqeg
     1501 imswspkekt yetdlavlqw veeleqrvim sdlqirgwtc pspdstredl aycehlsdsq
     1561 editwrgrgr eglapqrktt npldlavmrl aaleqnverr ylreplwpth evvlekalls
     1621 tpngapegtt teisplspsr syeitprirv wrqtlercrs aaqvclclgq lersiaweks
     1681 vnkvtclvcr kgdndeflll cdgcdrgchi ychrpkmeav pegdwfctvc laqqvegeft
     1741 qkpgfpkrgq krksgyslnf segdgrrrrv llrgrespaa gpryseegls pskrrrlsmr
     1801 nhhsdltfce iilmemeshd aawpflepvn prlvsgyrri iknpmdfstm rerllrggyt
     1861 sseefaadal lvfdncqtfn eddsevgkag himrrffesr weefyqgkqa nl
//
LOCUS       XP_054226841            1910 aa            linear   PRI 05-AUG-2025
DEFINITION  bromodomain adjacent to zinc finger domain protein 2A isoform X2
            [Homo sapiens].
ACCESSION   XP_054226841
VERSION     XP_054226841.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370866.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1910
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1910
                     /product="bromodomain adjacent to zinc finger domain
                     protein 2A isoform X2"
                     /calculated_mol_wt=211532
     Region          <390..>522
                     /region_name="PRK10856"
                     /note="cytoskeleton protein RodZ"
                     /db_xref="CDD:236776"
     Region          549..621
                     /region_name="HAT_MBD"
                     /note="Methyl-CpG binding domains (MBD) present in
                     putative chromatin remodelling factor such as BAZ2A; BAZ2A
                     contains a MBD, DDT, PHD-type zinc finger and Bromo domain
                     suggesting that BAZ2A might be associated with histone
                     acetyltransferase (HAT) activity. The...; cd01397"
                     /db_xref="CDD:238691"
     Site            order(561,563,565,572,574,583,586,590)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238691"
     Region          846..911
                     /region_name="DDT"
                     /note="domain in different transcription and chromosome
                     remodeling factors; smart00571"
                     /db_xref="CDD:214726"
     Region          1109..>1164
                     /region_name="WSD"
                     /note="Williams-Beuren syndrome DDT (WSD), D-TOX E motif;
                     pfam15613"
                     /db_xref="CDD:464775"
     Region          <1325..1428
                     /region_name="PHA03378"
                     /note="EBNA-3B; Provisional"
                     /db_xref="CDD:223065"
     Region          <1437..1471
                     /region_name="WSD"
                     /note="Williams-Beuren syndrome DDT (WSD), D-TOX E motif;
                     pfam15613"
                     /db_xref="CDD:464775"
     Region          1683..1729
                     /region_name="PHD_BAZ2A"
                     /note="PHD finger found in bromodomain adjacent to zinc
                     finger domain protein 2A (BAZ2A); cd15629"
                     /db_xref="CDD:277099"
     Site            order(1690,1693..1694,1696..1700,1718..1721)
                     /site_type="other"
                     /note="H3 histone binding site [polypeptide binding]"
                     /db_xref="CDD:277099"
     Region          1803..1899
                     /region_name="Bromo_BAZ2A_B_like"
                     /note="Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo
                     adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were
                     identified as a novel human bromodomain gene by cDNA
                     library screening. BAZ2A is also known as Tip5
                     (Transcription termination factor I-interacting...;
                     cd05503"
                     /db_xref="CDD:99935"
     Site            order(1827,1832,1835,1874,1878,1884)
                     /site_type="active"
                     /note="acetyllysine binding site [active]"
                     /db_xref="CDD:99935"
     CDS             1..1910
                     /gene="BAZ2A"
                     /gene_synonym="TIP5; WALp3"
                     /coded_by="XM_054370866.1:101..5833"
                     /db_xref="GeneID:11176"
                     /db_xref="HGNC:HGNC:962"
                     /db_xref="MIM:605682"
ORIGIN      
        1 meandhfnft glppapaasg lkpspssgeg lytngspmnf pqqgkslngd vnvnglstvs
       61 htttsgilns aphssstshl hhpsvaydcl wnysqypsan pgsnlkdppl lsqfsggqyp
      121 lngilggsrq psspshntnl ragsqefwan gtqspmglnf dsqelydsfp dqnfevmpng
      181 ppsfftspqt spmlgssiqt fapsqevgsg ihpdeaaeke mtsvvaengt glvgslelee
      241 eqpelkmcgy ngsvpsvesl hqevsvlvpd ptvsclddps hlpdqledtp ilsedslepf
      301 nslapepvsg glygiddtel mgaedklple dspvisaldc pslnnatafs lladdsqtst
      361 sifasptspp vlgesvlqdn sfdlnngsda eqeemetqss dfppsltqpa pdqsstiqlh
      421 patspavspt tspavslvvs paaspeispe vcpaastvvs pavfsvvspa ssavlpavsl
      481 evpltasvts pkaspvtspa aafptaspan kdvssflett adveeitgeg ltasgsgdvm
      541 rrriatpeev rlplqhgwrr evrikkgshr wqgetwyygp cgkrmkqfpe vikylsrnvv
      601 hsvrrehfsf sprmpvgdff eerdtpeglq wvqlsaeeip sriqaitgkr grprntekak
      661 tkevpkvkrg rgrppkvkit ellnktdnrp lkkleaqetl needkakiak skkkmrqkvq
      721 rgecqttiqg qarnkrkqet kslkqkeakk kskaekekgk tkqeklkekv krekkekvkm
      781 kekeevtkak packadktla tqrrleerqr qqmileemkk ptedmcltdh qplpdfsrvp
      841 gltlpsgafs dcltiveflh sfgkvlgfdp akdvpslgvl qegllcqgds lgevqdllvr
      901 llkaalhdpg fpsycqslki lgekvseipl trdnvseilr cflmaygvep alcdrlrtqp
      961 fqaqppqqka avlaflvhel ngstliinei dktlesmssy rknkwivegr lrrlktvlak
     1021 rtgrseveme gpeeclgrrr ssrimeetsg meeeeeeesi aavpgrrgrr dgevdatass
     1081 ipelerqiek lskrqlffrk kllhssqmlr avslgqdryr rrywvlpyla gifvegtegn
     1141 lvpeevikke tdslkvaaha slnpalfsmk melagsntta ssparargrp rktkpgsmqp
     1201 rhlkspvrgq dseqpqaqlq peaqlhapaq pqpqlqlqlq shkgfleqeg splslgqsqh
     1261 dlsqsaflsw lsqtqshssl lsssvltpds spgkldpaps qppeepepde aesspdpqal
     1321 wfnisaqmpc naaptpppav sedqptpspq qlasskpmnr psaanpcspv qfsstplagl
     1381 apkrragdpg empqsptglg qpkrrgrpps kffkqmeqry ltqltaqpvp pemcsgwwwi
     1441 rdpemldaml kalhprgire kalhkhlnkh rdflqevclr psadpifepr qlpafqegim
     1501 swspkektye tdlavlqwve eleqrvimsd lqirgwtcps pdstredlay cehlsdsqed
     1561 itwrgrgreg lapqrkttnp ldlavmrlaa leqnverryl replwpthev vlekallstp
     1621 ngapegttte isplspsrsy eitprirvwr qtlercrsaa qvclclgqle rsiaweksvn
     1681 kvtclvcrkg dndeflllcd gcdrgchiyc hrpkmeavpe gdwfctvcla qqvegeftqk
     1741 pgfpkrgqkr ksgyslnfse gdgrrrrvll rgrespaagp ryseeglsps krrrlsmrnh
     1801 hsdltfceii lmemeshdaa wpflepvnpr lvsgyrriik npmdfstmre rllrggytss
     1861 eefaadallv fdncqtfned dsevgkaghi mrrffesrwe efyqgkqanl
//
LOCUS       XP_054226842            1911 aa            linear   PRI 05-AUG-2025
DEFINITION  bromodomain adjacent to zinc finger domain protein 2A isoform X24
            [Homo sapiens].
ACCESSION   XP_054226842
VERSION     XP_054226842.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370867.1
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 1% of CDS bases
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1911
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1911
                     /product="bromodomain adjacent to zinc finger domain
                     protein 2A isoform X24"
                     /calculated_mol_wt=211664
     Region          <392..>524
                     /region_name="PRK10856"
                     /note="cytoskeleton protein RodZ"
                     /db_xref="CDD:236776"
     Region          551..623
                     /region_name="HAT_MBD"
                     /note="Methyl-CpG binding domains (MBD) present in
                     putative chromatin remodelling factor such as BAZ2A; BAZ2A
                     contains a MBD, DDT, PHD-type zinc finger and Bromo domain
                     suggesting that BAZ2A might be associated with histone
                     acetyltransferase (HAT) activity. The...; cd01397"
                     /db_xref="CDD:238691"
     Site            order(563,565,567,574,576,585,588,592)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238691"
     Region          848..913
                     /region_name="DDT"
                     /note="domain in different transcription and chromosome
                     remodeling factors; smart00571"
                     /db_xref="CDD:214726"
     Region          1111..>1166
                     /region_name="WSD"
                     /note="Williams-Beuren syndrome DDT (WSD), D-TOX E motif;
                     pfam15613"
                     /db_xref="CDD:464775"
     Region          <1327..1430
                     /region_name="PHA03378"
                     /note="EBNA-3B; Provisional"
                     /db_xref="CDD:223065"
     Region          <1439..1473
                     /region_name="WSD"
                     /note="Williams-Beuren syndrome DDT (WSD), D-TOX E motif;
                     pfam15613"
                     /db_xref="CDD:464775"
     Region          1685..1731
                     /region_name="PHD_BAZ2A"
                     /note="PHD finger found in bromodomain adjacent to zinc
                     finger domain protein 2A (BAZ2A); cd15629"
                     /db_xref="CDD:277099"
     Site            order(1692,1695..1696,1698..1702,1720..1723)
                     /site_type="other"
                     /note="H3 histone binding site [polypeptide binding]"
                     /db_xref="CDD:277099"
     Region          1804..1900
                     /region_name="Bromo_BAZ2A_B_like"
                     /note="Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo
                     adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were
                     identified as a novel human bromodomain gene by cDNA
                     library screening. BAZ2A is also known as Tip5
                     (Transcription termination factor I-interacting...;
                     cd05503"
                     /db_xref="CDD:99935"
     Site            order(1828,1833,1836,1875,1879,1885)
                     /site_type="active"
                     /note="acetyllysine binding site [active]"
                     /db_xref="CDD:99935"
     CDS             1..1911
                     /gene="BAZ2A"
                     /gene_synonym="TIP5; WALp3"
                     /coded_by="XM_054370867.1:175..5910"
                     /db_xref="GeneID:11176"
                     /db_xref="HGNC:HGNC:962"
                     /db_xref="MIM:605682"
ORIGIN      
        1 memeandhfn ftglppapaa sglkpspssg eglytngspm nfpqqgksln gdvnvnglst
       61 vshtttsgil nsaphsssts hlhhpsvayd clwnysqyps anpgsnlkdp pllsqfsggq
      121 yplngilggs rqpsspshnt nlragsqefw angtqspmgl nfdsqelyds fpdqnfevmp
      181 ngppsfftsp qtspmlgssi qtfapsqevg sgihpdeaae kemtsvvaen gtglvgslel
      241 eeeqpelkmc gyngsvpsve slhqevsvlv pdptvscldd pshlpdqled tpilsedsle
      301 pfnslapepv sgglygiddt elmgaedklp ledspvisal dcpslnnata fslladdsqt
      361 stsifaspts ppvlgesvlq dnsfdlnngs daeqeemetq ssdfppsltq papdqsstiq
      421 lhpatspavs pttspavslv vspaaspeis pevcpaastv vspavfsvvs passavlpav
      481 slevpltasv tspkaspvts paaafptasp ankdvssfle ttadveeitg egltasgsgd
      541 vmrrriatpe evrlplqhgw rrevrikkgs hrwqgetwyy gpcgkrmkqf pevikylsrn
      601 vvhsvrrehf sfsprmpvgd ffeerdtpeg lqwvqlsaee ipsriqaitg krgrprntek
      661 aktkevpkvk rgrgrppkvk itellnktdn rplkkleaqe tlneedkaki akskkkmrqk
      721 vqrgecqtti qgqarnkrkq etkslkqkea kkkskaekek gktkqeklke kvkrekkekv
      781 kmkekeevtk akpackadkt latqrrleer qrqqmileem kkptedmclt dhqplpdfsr
      841 vpgltlpsga fsdcltivef lhsfgkvlgf dpakdvpslg vlqegllcqg dslgevqdll
      901 vrllkaalhd pgfpsycqsl kilgekvsei pltrdnvsei lrcflmaygv epalcdrlrt
      961 qpfqaqppqq kaavlaflvh elngstliin eidktlesms syrknkwive grlrrlktvl
     1021 akrtgrseve megpeeclgr rrssrimeet sgmeeeeeee siaavpgrrg rrdgevdata
     1081 ssipelerqi eklskrqlff rkkllhssqm lravslgqdr yrrrywvlpy lagifvegte
     1141 gnlvpeevik ketdslkvaa haslnpalfs mkmelagsnt tasspararg rprktkpgsm
     1201 qprhlkspvr gqdseqpqaq lqpeaqlhap aqpqpqlqlq lqshkgfleq egsplslgqs
     1261 qhdlsqsafl swlsqtqshs sllsssvltp dsspgkldpa psqppeepep deaesspdpq
     1321 alwfnisaqm pcnaaptppp avsedqptps pqqlasskpm nrpsaanpcs pvqfsstpla
     1381 glapkrragd pgempqsptg lgqpkrrgrp pskffkqmeq ryltqltaqp vppemcsgww
     1441 wirdpemlda mlkalhprgi rekalhkhln khrdflqevc lrpsadpife prqlpafqeg
     1501 imswspkekt yetdlavlqw veeleqrvim sdlqirgwtc pspdstredl aycehlsdsq
     1561 editwrgrgr eglapqrktt npldlavmrl aaleqnverr ylreplwpth evvlekalls
     1621 tpngapegtt teisplspsr syeitprirv wrqtlercrs aaqvclclgq lersiaweks
     1681 vnkvtclvcr kgdndeflll cdgcdrgchi ychrpkmeav pegdwfctvc laqvegeftq
     1741 kpgfpkrgqk rksgyslnfs egdgrrrrvl lrgrespaag pryseeglsp skrrrlsmrn
     1801 hhsdltfcei ilmemeshda awpflepvnp rlvsgyrrii knpmdfstmr erllrggyts
     1861 seefaadall vfdncqtfne ddsevgkagh imrrffesrw eefyqgkqan l
//
LOCUS       XP_054226843            1955 aa            linear   PRI 05-AUG-2025
DEFINITION  bromodomain adjacent to zinc finger domain protein 2A isoform X4
            [Homo sapiens].
ACCESSION   XP_054226843
VERSION     XP_054226843.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370868.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1955
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1955
                     /product="bromodomain adjacent to zinc finger domain
                     protein 2A isoform X4"
                     /calculated_mol_wt=216405
     Region          <442..>574
                     /region_name="PRK10856"
                     /note="cytoskeleton protein RodZ"
                     /db_xref="CDD:236776"
     Region          601..673
                     /region_name="HAT_MBD"
                     /note="Methyl-CpG binding domains (MBD) present in
                     putative chromatin remodelling factor such as BAZ2A; BAZ2A
                     contains a MBD, DDT, PHD-type zinc finger and Bromo domain
                     suggesting that BAZ2A might be associated with histone
                     acetyltransferase (HAT) activity. The...; cd01397"
                     /db_xref="CDD:238691"
     Site            order(613,615,617,624,626,635,638,642)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238691"
     Region          898..963
                     /region_name="DDT"
                     /note="domain in different transcription and chromosome
                     remodeling factors; smart00571"
                     /db_xref="CDD:214726"
     Region          1161..>1216
                     /region_name="WSD"
                     /note="Williams-Beuren syndrome DDT (WSD), D-TOX E motif;
                     pfam15613"
                     /db_xref="CDD:464775"
     Region          <1377..1480
                     /region_name="PHA03378"
                     /note="EBNA-3B; Provisional"
                     /db_xref="CDD:223065"
     Region          <1489..1523
                     /region_name="WSD"
                     /note="Williams-Beuren syndrome DDT (WSD), D-TOX E motif;
                     pfam15613"
                     /db_xref="CDD:464775"
     Region          1728..1774
                     /region_name="PHD_BAZ2A"
                     /note="PHD finger found in bromodomain adjacent to zinc
                     finger domain protein 2A (BAZ2A); cd15629"
                     /db_xref="CDD:277099"
     Site            order(1735,1738..1739,1741..1745,1763..1766)
                     /site_type="other"
                     /note="H3 histone binding site [polypeptide binding]"
                     /db_xref="CDD:277099"
     Region          1848..1944
                     /region_name="Bromo_BAZ2A_B_like"
                     /note="Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo
                     adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were
                     identified as a novel human bromodomain gene by cDNA
                     library screening. BAZ2A is also known as Tip5
                     (Transcription termination factor I-interacting...;
                     cd05503"
                     /db_xref="CDD:99935"
     Site            order(1872,1877,1880,1919,1923,1929)
                     /site_type="active"
                     /note="acetyllysine binding site [active]"
                     /db_xref="CDD:99935"
     CDS             1..1955
                     /gene="BAZ2A"
                     /gene_synonym="TIP5; WALp3"
                     /coded_by="XM_054370868.1:121..5988"
                     /db_xref="GeneID:11176"
                     /db_xref="HGNC:HGNC:962"
                     /db_xref="MIM:605682"
ORIGIN      
        1 miwteggape llvlfpahsl ggsntnlyvk wgpkdseelg gpslelcqpd memeandhfn
       61 ftglppapaa sglkpspssg eglytngspm nfpqqgksln gdvnvnglst vshtttsgil
      121 nsaphsssts hlhhpsvayd clwnysqyps anpgsnlkdp pllsqfsggq yplngilggs
      181 rqpsspshnt nlragsqefw angtqspmgl nfdsqelyds fpdqnfevmp ngppsfftsp
      241 qtspmlgssi qtfapsqevg sgihpdeaae kemtsvvaen gtglvgslel eeeqpelkmc
      301 gyngsvpsve slhqevsvlv pdptvscldd pshlpdqled tpilsedsle pfnslapepv
      361 sgglygiddt elmgaedklp ledspvisal dcpslnnata fslladdsqt stsifaspts
      421 ppvlgesvlq dnsfdlnngs daeqeemetq ssdfppsltq papdqsstiq lhpatspavs
      481 pttspavslv vspaaspeis pevcpaastv vspavfsvvs passavlpav slevpltasv
      541 tspkaspvts paaafptasp ankdvssfle ttadveeitg egltasgsgd vmrrriatpe
      601 evrlplqhgw rrevrikkgs hrwqgetwyy gpcgkrmkqf pevikylsrn vvhsvrrehf
      661 sfsprmpvgd ffeerdtpeg lqwvqlsaee ipsriqaitg krgrprntek aktkevpkvk
      721 rgrgrppkvk itellnktdn rplkkleaqe tlneedkaki akskkkmrqk vqrgecqtti
      781 qgqarnkrkq etkslkqkea kkkskaekek gktkqeklke kvkrekkekv kmkekeevtk
      841 akpackadkt latqrrleer qrqqmileem kkptedmclt dhqplpdfsr vpgltlpsga
      901 fsdcltivef lhsfgkvlgf dpakdvpslg vlqegllcqg dslgevqdll vrllkaalhd
      961 pgfpsycqsl kilgekvsei pltrdnvsei lrcflmaygv epalcdrlrt qpfqaqppqq
     1021 kaavlaflvh elngstliin eidktlesms syrknkwive grlrrlktvl akrtgrseve
     1081 megpeeclgr rrssrimeet sgmeeeeeee siaavpgrrg rrdgevdata ssipelerqi
     1141 eklskrqlff rkkllhssqm lravslgqdr yrrrywvlpy lagifvegte gnlvpeevik
     1201 ketdslkvaa haslnpalfs mkmelagsnt tasspararg rprktkpgsm qprhlkspvr
     1261 gqdseqpqaq lqpeaqlhap aqpqpqlqlq lqshkgfleq egsplslgqs qhdlsqsafl
     1321 swlsqtqshs sllsssvltp dsspgkldpa psqppeepep deaesspdpq alwfnisaqm
     1381 pcnaaptppp avsedqptps pqqlasskpm nrpsaanpcs pvqfsstpla glapkrragd
     1441 pgempqsptg lgqpkrrgrp pskffkqmeq ryltqltaqp vppemcsgww wirdpemlda
     1501 mlkalhprgi rekalhkhln khrdflqevc lrpsadpife prqlpafqeg imswspkekt
     1561 yetdlavlqw veeleqrvim sdlqirgwtc pspdstredl aycehlsdsq editwrgrgr
     1621 eglapqrktt npldlavmrl aaleqnverr ylreplwpth evvlekalls tpngapegtt
     1681 teisyeitpr irvwrqtler crsaaqvclc lgqlersiaw eksvnkvtcl vcrkgdndef
     1741 lllcdgcdrg chiychrpkm eavpegdwfc tvclaqqveg eftqkpgfpk rgqkrksgys
     1801 lnfsegdgrr rrvllrgres paagprysee glspskrrrl smrnhhsdlt fceiilmeme
     1861 shdaawpfle pvnprlvsgy rriiknpmdf stmrerllrg gytsseefaa dallvfdncq
     1921 tfneddsevg kaghimrrff esrweefyqg kqanl
//
LOCUS       XP_054226844            1903 aa            linear   PRI 05-AUG-2025
DEFINITION  bromodomain adjacent to zinc finger domain protein 2A isoform X5
            [Homo sapiens].
ACCESSION   XP_054226844
VERSION     XP_054226844.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370869.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1903
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1903
                     /product="bromodomain adjacent to zinc finger domain
                     protein 2A isoform X5"
                     /calculated_mol_wt=210807
     Region          <390..>522
                     /region_name="PRK10856"
                     /note="cytoskeleton protein RodZ"
                     /db_xref="CDD:236776"
     Region          549..621
                     /region_name="HAT_MBD"
                     /note="Methyl-CpG binding domains (MBD) present in
                     putative chromatin remodelling factor such as BAZ2A; BAZ2A
                     contains a MBD, DDT, PHD-type zinc finger and Bromo domain
                     suggesting that BAZ2A might be associated with histone
                     acetyltransferase (HAT) activity. The...; cd01397"
                     /db_xref="CDD:238691"
     Site            order(561,563,565,572,574,583,586,590)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238691"
     Region          846..911
                     /region_name="DDT"
                     /note="domain in different transcription and chromosome
                     remodeling factors; smart00571"
                     /db_xref="CDD:214726"
     Region          1109..>1164
                     /region_name="WSD"
                     /note="Williams-Beuren syndrome DDT (WSD), D-TOX E motif;
                     pfam15613"
                     /db_xref="CDD:464775"
     Region          <1325..1428
                     /region_name="PHA03378"
                     /note="EBNA-3B; Provisional"
                     /db_xref="CDD:223065"
     Region          <1437..1471
                     /region_name="WSD"
                     /note="Williams-Beuren syndrome DDT (WSD), D-TOX E motif;
                     pfam15613"
                     /db_xref="CDD:464775"
     Region          1676..1722
                     /region_name="PHD_BAZ2A"
                     /note="PHD finger found in bromodomain adjacent to zinc
                     finger domain protein 2A (BAZ2A); cd15629"
                     /db_xref="CDD:277099"
     Site            order(1683,1686..1687,1689..1693,1711..1714)
                     /site_type="other"
                     /note="H3 histone binding site [polypeptide binding]"
                     /db_xref="CDD:277099"
     Region          1796..1892
                     /region_name="Bromo_BAZ2A_B_like"
                     /note="Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo
                     adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were
                     identified as a novel human bromodomain gene by cDNA
                     library screening. BAZ2A is also known as Tip5
                     (Transcription termination factor I-interacting...;
                     cd05503"
                     /db_xref="CDD:99935"
     Site            order(1820,1825,1828,1867,1871,1877)
                     /site_type="active"
                     /note="acetyllysine binding site [active]"
                     /db_xref="CDD:99935"
     CDS             1..1903
                     /gene="BAZ2A"
                     /gene_synonym="TIP5; WALp3"
                     /coded_by="XM_054370869.1:101..5812"
                     /db_xref="GeneID:11176"
                     /db_xref="HGNC:HGNC:962"
                     /db_xref="MIM:605682"
ORIGIN      
        1 meandhfnft glppapaasg lkpspssgeg lytngspmnf pqqgkslngd vnvnglstvs
       61 htttsgilns aphssstshl hhpsvaydcl wnysqypsan pgsnlkdppl lsqfsggqyp
      121 lngilggsrq psspshntnl ragsqefwan gtqspmglnf dsqelydsfp dqnfevmpng
      181 ppsfftspqt spmlgssiqt fapsqevgsg ihpdeaaeke mtsvvaengt glvgslelee
      241 eqpelkmcgy ngsvpsvesl hqevsvlvpd ptvsclddps hlpdqledtp ilsedslepf
      301 nslapepvsg glygiddtel mgaedklple dspvisaldc pslnnatafs lladdsqtst
      361 sifasptspp vlgesvlqdn sfdlnngsda eqeemetqss dfppsltqpa pdqsstiqlh
      421 patspavspt tspavslvvs paaspeispe vcpaastvvs pavfsvvspa ssavlpavsl
      481 evpltasvts pkaspvtspa aafptaspan kdvssflett adveeitgeg ltasgsgdvm
      541 rrriatpeev rlplqhgwrr evrikkgshr wqgetwyygp cgkrmkqfpe vikylsrnvv
      601 hsvrrehfsf sprmpvgdff eerdtpeglq wvqlsaeeip sriqaitgkr grprntekak
      661 tkevpkvkrg rgrppkvkit ellnktdnrp lkkleaqetl needkakiak skkkmrqkvq
      721 rgecqttiqg qarnkrkqet kslkqkeakk kskaekekgk tkqeklkekv krekkekvkm
      781 kekeevtkak packadktla tqrrleerqr qqmileemkk ptedmcltdh qplpdfsrvp
      841 gltlpsgafs dcltiveflh sfgkvlgfdp akdvpslgvl qegllcqgds lgevqdllvr
      901 llkaalhdpg fpsycqslki lgekvseipl trdnvseilr cflmaygvep alcdrlrtqp
      961 fqaqppqqka avlaflvhel ngstliinei dktlesmssy rknkwivegr lrrlktvlak
     1021 rtgrseveme gpeeclgrrr ssrimeetsg meeeeeeesi aavpgrrgrr dgevdatass
     1081 ipelerqiek lskrqlffrk kllhssqmlr avslgqdryr rrywvlpyla gifvegtegn
     1141 lvpeevikke tdslkvaaha slnpalfsmk melagsntta ssparargrp rktkpgsmqp
     1201 rhlkspvrgq dseqpqaqlq peaqlhapaq pqpqlqlqlq shkgfleqeg splslgqsqh
     1261 dlsqsaflsw lsqtqshssl lsssvltpds spgkldpaps qppeepepde aesspdpqal
     1321 wfnisaqmpc naaptpppav sedqptpspq qlasskpmnr psaanpcspv qfsstplagl
     1381 apkrragdpg empqsptglg qpkrrgrpps kffkqmeqry ltqltaqpvp pemcsgwwwi
     1441 rdpemldaml kalhprgire kalhkhlnkh rdflqevclr psadpifepr qlpafqegim
     1501 swspkektye tdlavlqwve eleqrvimsd lqirgwtcps pdstredlay cehlsdsqed
     1561 itwrgrgreg lapqrkttnp ldlavmrlaa leqnverryl replwpthev vlekallstp
     1621 ngapegttte isyeitprir vwrqtlercr saaqvclclg qlersiawek svnkvtclvc
     1681 rkgdndefll lcdgcdrgch iychrpkmea vpegdwfctv claqqvegef tqkpgfpkrg
     1741 qkrksgysln fsegdgrrrr vllrgrespa agpryseegl spskrrrlsm rnhhsdltfc
     1801 eiilmemesh daawpflepv nprlvsgyrr iiknpmdfst mrerllrggy tsseefaada
     1861 llvfdncqtf neddsevgka ghimrrffes rweefyqgkq anl
//
LOCUS       XP_054226845            1954 aa            linear   PRI 05-AUG-2025
DEFINITION  bromodomain adjacent to zinc finger domain protein 2A isoform X6
            [Homo sapiens].
ACCESSION   XP_054226845
VERSION     XP_054226845.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370870.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1954
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1954
                     /product="bromodomain adjacent to zinc finger domain
                     protein 2A isoform X6"
                     /calculated_mol_wt=216276
     Region          <442..>574
                     /region_name="PRK10856"
                     /note="cytoskeleton protein RodZ"
                     /db_xref="CDD:236776"
     Region          601..673
                     /region_name="HAT_MBD"
                     /note="Methyl-CpG binding domains (MBD) present in
                     putative chromatin remodelling factor such as BAZ2A; BAZ2A
                     contains a MBD, DDT, PHD-type zinc finger and Bromo domain
                     suggesting that BAZ2A might be associated with histone
                     acetyltransferase (HAT) activity. The...; cd01397"
                     /db_xref="CDD:238691"
     Site            order(613,615,617,624,626,635,638,642)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238691"
     Region          898..963
                     /region_name="DDT"
                     /note="domain in different transcription and chromosome
                     remodeling factors; smart00571"
                     /db_xref="CDD:214726"
     Region          1161..>1216
                     /region_name="WSD"
                     /note="Williams-Beuren syndrome DDT (WSD), D-TOX E motif;
                     pfam15613"
                     /db_xref="CDD:464775"
     Region          <1377..1480
                     /region_name="PHA03378"
                     /note="EBNA-3B; Provisional"
                     /db_xref="CDD:223065"
     Region          <1489..1523
                     /region_name="WSD"
                     /note="Williams-Beuren syndrome DDT (WSD), D-TOX E motif;
                     pfam15613"
                     /db_xref="CDD:464775"
     Region          1728..1774
                     /region_name="PHD_BAZ2A"
                     /note="PHD finger found in bromodomain adjacent to zinc
                     finger domain protein 2A (BAZ2A); cd15629"
                     /db_xref="CDD:277099"
     Site            order(1735,1738..1739,1741..1745,1763..1766)
                     /site_type="other"
                     /note="H3 histone binding site [polypeptide binding]"
                     /db_xref="CDD:277099"
     Region          1847..1943
                     /region_name="Bromo_BAZ2A_B_like"
                     /note="Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo
                     adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were
                     identified as a novel human bromodomain gene by cDNA
                     library screening. BAZ2A is also known as Tip5
                     (Transcription termination factor I-interacting...;
                     cd05503"
                     /db_xref="CDD:99935"
     Site            order(1871,1876,1879,1918,1922,1928)
                     /site_type="active"
                     /note="acetyllysine binding site [active]"
                     /db_xref="CDD:99935"
     CDS             1..1954
                     /gene="BAZ2A"
                     /gene_synonym="TIP5; WALp3"
                     /coded_by="XM_054370870.1:53..5917"
                     /db_xref="GeneID:11176"
                     /db_xref="HGNC:HGNC:962"
                     /db_xref="MIM:605682"
ORIGIN      
        1 miwteggape llvlfpahsl ggsntnlyvk wgpkdseelg gpslelcqpd memeandhfn
       61 ftglppapaa sglkpspssg eglytngspm nfpqqgksln gdvnvnglst vshtttsgil
      121 nsaphsssts hlhhpsvayd clwnysqyps anpgsnlkdp pllsqfsggq yplngilggs
      181 rqpsspshnt nlragsqefw angtqspmgl nfdsqelyds fpdqnfevmp ngppsfftsp
      241 qtspmlgssi qtfapsqevg sgihpdeaae kemtsvvaen gtglvgslel eeeqpelkmc
      301 gyngsvpsve slhqevsvlv pdptvscldd pshlpdqled tpilsedsle pfnslapepv
      361 sgglygiddt elmgaedklp ledspvisal dcpslnnata fslladdsqt stsifaspts
      421 ppvlgesvlq dnsfdlnngs daeqeemetq ssdfppsltq papdqsstiq lhpatspavs
      481 pttspavslv vspaaspeis pevcpaastv vspavfsvvs passavlpav slevpltasv
      541 tspkaspvts paaafptasp ankdvssfle ttadveeitg egltasgsgd vmrrriatpe
      601 evrlplqhgw rrevrikkgs hrwqgetwyy gpcgkrmkqf pevikylsrn vvhsvrrehf
      661 sfsprmpvgd ffeerdtpeg lqwvqlsaee ipsriqaitg krgrprntek aktkevpkvk
      721 rgrgrppkvk itellnktdn rplkkleaqe tlneedkaki akskkkmrqk vqrgecqtti
      781 qgqarnkrkq etkslkqkea kkkskaekek gktkqeklke kvkrekkekv kmkekeevtk
      841 akpackadkt latqrrleer qrqqmileem kkptedmclt dhqplpdfsr vpgltlpsga
      901 fsdcltivef lhsfgkvlgf dpakdvpslg vlqegllcqg dslgevqdll vrllkaalhd
      961 pgfpsycqsl kilgekvsei pltrdnvsei lrcflmaygv epalcdrlrt qpfqaqppqq
     1021 kaavlaflvh elngstliin eidktlesms syrknkwive grlrrlktvl akrtgrseve
     1081 megpeeclgr rrssrimeet sgmeeeeeee siaavpgrrg rrdgevdata ssipelerqi
     1141 eklskrqlff rkkllhssqm lravslgqdr yrrrywvlpy lagifvegte gnlvpeevik
     1201 ketdslkvaa haslnpalfs mkmelagsnt tasspararg rprktkpgsm qprhlkspvr
     1261 gqdseqpqaq lqpeaqlhap aqpqpqlqlq lqshkgfleq egsplslgqs qhdlsqsafl
     1321 swlsqtqshs sllsssvltp dsspgkldpa psqppeepep deaesspdpq alwfnisaqm
     1381 pcnaaptppp avsedqptps pqqlasskpm nrpsaanpcs pvqfsstpla glapkrragd
     1441 pgempqsptg lgqpkrrgrp pskffkqmeq ryltqltaqp vppemcsgww wirdpemlda
     1501 mlkalhprgi rekalhkhln khrdflqevc lrpsadpife prqlpafqeg imswspkekt
     1561 yetdlavlqw veeleqrvim sdlqirgwtc pspdstredl aycehlsdsq editwrgrgr
     1621 eglapqrktt npldlavmrl aaleqnverr ylreplwpth evvlekalls tpngapegtt
     1681 teisyeitpr irvwrqtler crsaaqvclc lgqlersiaw eksvnkvtcl vcrkgdndef
     1741 lllcdgcdrg chiychrpkm eavpegdwfc tvclaqvege ftqkpgfpkr gqkrksgysl
     1801 nfsegdgrrr rvllrgresp aagpryseeg lspskrrrls mrnhhsdltf ceiilmemes
     1861 hdaawpflep vnprlvsgyr riiknpmdfs tmrerllrgg ytsseefaad allvfdncqt
     1921 fneddsevgk aghimrrffe srweefyqgk qanl
//
LOCUS       XP_054226846            1882 aa            linear   PRI 05-AUG-2025
DEFINITION  bromodomain adjacent to zinc finger domain protein 2A isoform X25
            [Homo sapiens].
ACCESSION   XP_054226846
VERSION     XP_054226846.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370871.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1882
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1882
                     /product="bromodomain adjacent to zinc finger domain
                     protein 2A isoform X25"
                     /calculated_mol_wt=208671
     Region          <362..>494
                     /region_name="PRK10856"
                     /note="cytoskeleton protein RodZ"
                     /db_xref="CDD:236776"
     Region          521..593
                     /region_name="HAT_MBD"
                     /note="Methyl-CpG binding domains (MBD) present in
                     putative chromatin remodelling factor such as BAZ2A; BAZ2A
                     contains a MBD, DDT, PHD-type zinc finger and Bromo domain
                     suggesting that BAZ2A might be associated with histone
                     acetyltransferase (HAT) activity. The...; cd01397"
                     /db_xref="CDD:238691"
     Site            order(533,535,537,544,546,555,558,562)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238691"
     Region          818..883
                     /region_name="DDT"
                     /note="domain in different transcription and chromosome
                     remodeling factors; smart00571"
                     /db_xref="CDD:214726"
     Region          1081..>1136
                     /region_name="WSD"
                     /note="Williams-Beuren syndrome DDT (WSD), D-TOX E motif;
                     pfam15613"
                     /db_xref="CDD:464775"
     Region          <1297..1400
                     /region_name="PHA03378"
                     /note="EBNA-3B; Provisional"
                     /db_xref="CDD:223065"
     Region          <1409..1443
                     /region_name="WSD"
                     /note="Williams-Beuren syndrome DDT (WSD), D-TOX E motif;
                     pfam15613"
                     /db_xref="CDD:464775"
     Region          1655..1701
                     /region_name="PHD_BAZ2A"
                     /note="PHD finger found in bromodomain adjacent to zinc
                     finger domain protein 2A (BAZ2A); cd15629"
                     /db_xref="CDD:277099"
     Site            order(1662,1665..1666,1668..1672,1690..1693)
                     /site_type="other"
                     /note="H3 histone binding site [polypeptide binding]"
                     /db_xref="CDD:277099"
     Region          1775..1871
                     /region_name="Bromo_BAZ2A_B_like"
                     /note="Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo
                     adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were
                     identified as a novel human bromodomain gene by cDNA
                     library screening. BAZ2A is also known as Tip5
                     (Transcription termination factor I-interacting...;
                     cd05503"
                     /db_xref="CDD:99935"
     Site            order(1799,1804,1807,1846,1850,1856)
                     /site_type="active"
                     /note="acetyllysine binding site [active]"
                     /db_xref="CDD:99935"
     CDS             1..1882
                     /gene="BAZ2A"
                     /gene_synonym="TIP5; WALp3"
                     /coded_by="XM_054370871.1:175..5823"
                     /db_xref="GeneID:11176"
                     /db_xref="HGNC:HGNC:962"
                     /db_xref="MIM:605682"
ORIGIN      
        1 memeandhfn ftglppapaa sglkpspssg eglytngspm nfpqqgksln gdvnvnglst
       61 vshtttsgil nsaphsssts hlhhpsvayd clwnysqyps anpgsnlkdp pllsqfsggq
      121 yplngilggs rqpsspshnt nlragsqefw angtqspmgl nfdsqelyds fpdqnfeevg
      181 sgihpdeaae kemtsvvaen gtglvgslel eeeqpelkmc gyngsvpsve slhqevsvlv
      241 pdptvscldd pshlpdqled tpilsedsle pfnslapepv sgglygiddt elmgaedklp
      301 ledspvisal dcpslnnata fslladdsqt stsifaspts ppvlgesvlq dnsfdlnngs
      361 daeqeemetq ssdfppsltq papdqsstiq lhpatspavs pttspavslv vspaaspeis
      421 pevcpaastv vspavfsvvs passavlpav slevpltasv tspkaspvts paaafptasp
      481 ankdvssfle ttadveeitg egltasgsgd vmrrriatpe evrlplqhgw rrevrikkgs
      541 hrwqgetwyy gpcgkrmkqf pevikylsrn vvhsvrrehf sfsprmpvgd ffeerdtpeg
      601 lqwvqlsaee ipsriqaitg krgrprntek aktkevpkvk rgrgrppkvk itellnktdn
      661 rplkkleaqe tlneedkaki akskkkmrqk vqrgecqtti qgqarnkrkq etkslkqkea
      721 kkkskaekek gktkqeklke kvkrekkekv kmkekeevtk akpackadkt latqrrleer
      781 qrqqmileem kkptedmclt dhqplpdfsr vpgltlpsga fsdcltivef lhsfgkvlgf
      841 dpakdvpslg vlqegllcqg dslgevqdll vrllkaalhd pgfpsycqsl kilgekvsei
      901 pltrdnvsei lrcflmaygv epalcdrlrt qpfqaqppqq kaavlaflvh elngstliin
      961 eidktlesms syrknkwive grlrrlktvl akrtgrseve megpeeclgr rrssrimeet
     1021 sgmeeeeeee siaavpgrrg rrdgevdata ssipelerqi eklskrqlff rkkllhssqm
     1081 lravslgqdr yrrrywvlpy lagifvegte gnlvpeevik ketdslkvaa haslnpalfs
     1141 mkmelagsnt tasspararg rprktkpgsm qprhlkspvr gqdseqpqaq lqpeaqlhap
     1201 aqpqpqlqlq lqshkgfleq egsplslgqs qhdlsqsafl swlsqtqshs sllsssvltp
     1261 dsspgkldpa psqppeepep deaesspdpq alwfnisaqm pcnaaptppp avsedqptps
     1321 pqqlasskpm nrpsaanpcs pvqfsstpla glapkrragd pgempqsptg lgqpkrrgrp
     1381 pskffkqmeq ryltqltaqp vppemcsgww wirdpemlda mlkalhprgi rekalhkhln
     1441 khrdflqevc lrpsadpife prqlpafqeg imswspkekt yetdlavlqw veeleqrvim
     1501 sdlqirgwtc pspdstredl aycehlsdsq editwrgrgr eglapqrktt npldlavmrl
     1561 aaleqnverr ylreplwpth evvlekalls tpngapegtt teisplspsr syeitprirv
     1621 wrqtlercrs aaqvclclgq lersiaweks vnkvtclvcr kgdndeflll cdgcdrgchi
     1681 ychrpkmeav pegdwfctvc laqqvegeft qkpgfpkrgq krksgyslnf segdgrrrrv
     1741 llrgrespaa gpryseegls pskrrrlsmr nhhsdltfce iilmemeshd aawpflepvn
     1801 prlvsgyrri iknpmdfstm rerllrggyt sseefaadal lvfdncqtfn eddsevgkag
     1861 himrrffesr weefyqgkqa nl
//
LOCUS       XP_054226847            1931 aa            linear   PRI 05-AUG-2025
DEFINITION  bromodomain adjacent to zinc finger domain protein 2A isoform X8
            [Homo sapiens].
ACCESSION   XP_054226847
VERSION     XP_054226847.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370872.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1931
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1931
                     /product="bromodomain adjacent to zinc finger domain
                     protein 2A isoform X8"
                     /calculated_mol_wt=213885
     Region          <411..>543
                     /region_name="PRK10856"
                     /note="cytoskeleton protein RodZ"
                     /db_xref="CDD:236776"
     Region          570..642
                     /region_name="HAT_MBD"
                     /note="Methyl-CpG binding domains (MBD) present in
                     putative chromatin remodelling factor such as BAZ2A; BAZ2A
                     contains a MBD, DDT, PHD-type zinc finger and Bromo domain
                     suggesting that BAZ2A might be associated with histone
                     acetyltransferase (HAT) activity. The...; cd01397"
                     /db_xref="CDD:238691"
     Site            order(582,584,586,593,595,604,607,611)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238691"
     Region          867..932
                     /region_name="DDT"
                     /note="domain in different transcription and chromosome
                     remodeling factors; smart00571"
                     /db_xref="CDD:214726"
     Region          1130..>1185
                     /region_name="WSD"
                     /note="Williams-Beuren syndrome DDT (WSD), D-TOX E motif;
                     pfam15613"
                     /db_xref="CDD:464775"
     Region          <1346..1449
                     /region_name="PHA03378"
                     /note="EBNA-3B; Provisional"
                     /db_xref="CDD:223065"
     Region          <1458..1492
                     /region_name="WSD"
                     /note="Williams-Beuren syndrome DDT (WSD), D-TOX E motif;
                     pfam15613"
                     /db_xref="CDD:464775"
     Region          1704..1750
                     /region_name="PHD_BAZ2A"
                     /note="PHD finger found in bromodomain adjacent to zinc
                     finger domain protein 2A (BAZ2A); cd15629"
                     /db_xref="CDD:277099"
     Site            order(1711,1714..1715,1717..1721,1739..1742)
                     /site_type="other"
                     /note="H3 histone binding site [polypeptide binding]"
                     /db_xref="CDD:277099"
     Region          1824..1920
                     /region_name="Bromo_BAZ2A_B_like"
                     /note="Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo
                     adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were
                     identified as a novel human bromodomain gene by cDNA
                     library screening. BAZ2A is also known as Tip5
                     (Transcription termination factor I-interacting...;
                     cd05503"
                     /db_xref="CDD:99935"
     Site            order(1848,1853,1856,1895,1899,1905)
                     /site_type="active"
                     /note="acetyllysine binding site [active]"
                     /db_xref="CDD:99935"
     CDS             1..1931
                     /gene="BAZ2A"
                     /gene_synonym="TIP5; WALp3"
                     /coded_by="XM_054370872.1:372..6167"
                     /db_xref="GeneID:11176"
                     /db_xref="HGNC:HGNC:962"
                     /db_xref="MIM:605682"
ORIGIN      
        1 mevacilhtr ggvqktgerr emeandhfnf tglppapaas glkpspssge glytngspmn
       61 fpqqgkslng dvnvnglstv shtttsgiln saphssstsh lhhpsvaydc lwnysqypsa
      121 npgsnlkdpp llsqfsggqy plngilggsr qpsspshntn lragsqefwa ngtqspmgln
      181 fdsqelydsf pdqnfevmpn gppsfftspq tspmlgssiq tfapsqevgs gihpdeaaek
      241 emtsvvaeng tglvgslele eeqpelkmcg yngsvpsves lhqevsvlvp dptvsclddp
      301 shlpdqledt pilsedslep fnslapepvs gglygiddte lmgaedklpl edspvisald
      361 cpslnnataf slladdsqts tsifasptsp pvlgesvlqd nsfdlnngsd aeqeemetqs
      421 sdfppsltqp apdqsstiql hpatspavsp ttspavslvv spaaspeisp evcpaastvv
      481 spavfsvvsp assavlpavs levpltasvt spkaspvtsp aaafptaspa nkdvssflet
      541 tadveeitge gltasgsgdv mrrriatpee vrlplqhgwr revrikkgsh rwqgetwyyg
      601 pcgkrmkqfp evikylsrnv vhsvrrehfs fsprmpvgdf feerdtpegl qwvqlsaeei
      661 psriqaitgk rgrprnteka ktkevpkvkr grgrppkvki tellnktdnr plkkleaqet
      721 lneedkakia kskkkmrqkv qrgecqttiq gqarnkrkqe tkslkqkeak kkskaekekg
      781 ktkqeklkek vkrekkekvk mkekeevtka kpackadktl atqrrleerq rqqmileemk
      841 kptedmcltd hqplpdfsrv pgltlpsgaf sdcltivefl hsfgkvlgfd pakdvpslgv
      901 lqegllcqgd slgevqdllv rllkaalhdp gfpsycqslk ilgekvseip ltrdnvseil
      961 rcflmaygve palcdrlrtq pfqaqppqqk aavlaflvhe lngstliine idktlesmss
     1021 yrknkwiveg rlrrlktvla krtgrsevem egpeeclgrr rssrimeets gmeeeeeees
     1081 iaavpgrrgr rdgevdatas sipelerqie klskrqlffr kkllhssqml ravslgqdry
     1141 rrrywvlpyl agifvegteg nlvpeevikk etdslkvaah aslnpalfsm kmelagsntt
     1201 assparargr prktkpgsmq prhlkspvrg qdseqpqaql qpeaqlhapa qpqpqlqlql
     1261 qshkgfleqe gsplslgqsq hdlsqsafls wlsqtqshss llsssvltpd sspgkldpap
     1321 sqppeepepd eaesspdpqa lwfnisaqmp cnaaptpppa vsedqptpsp qqlasskpmn
     1381 rpsaanpcsp vqfsstplag lapkrragdp gempqsptgl gqpkrrgrpp skffkqmeqr
     1441 yltqltaqpv ppemcsgwww irdpemldam lkalhprgir ekalhkhlnk hrdflqevcl
     1501 rpsadpifep rqlpafqegi mswspkekty etdlavlqwv eeleqrvims dlqirgwtcp
     1561 spdstredla ycehlsdsqe ditwrgrgre glapqrkttn pldlavmrla aleqnverry
     1621 lreplwpthe vvlekallst pngapegttt eisplspsrs yeitprirvw rqtlercrsa
     1681 aqvclclgql ersiaweksv nkvtclvcrk gdndeflllc dgcdrgchiy chrpkmeavp
     1741 egdwfctvcl aqqvegeftq kpgfpkrgqk rksgyslnfs egdgrrrrvl lrgrespaag
     1801 pryseeglsp skrrrlsmrn hhsdltfcei ilmemeshda awpflepvnp rlvsgyrrii
     1861 knpmdfstmr erllrggyts seefaadall vfdncqtfne ddsevgkagh imrrffesrw
     1921 eefyqgkqan l
//
LOCUS       XP_054226848            1931 aa            linear   PRI 05-AUG-2025
DEFINITION  bromodomain adjacent to zinc finger domain protein 2A isoform X8
            [Homo sapiens].
ACCESSION   XP_054226848
VERSION     XP_054226848.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370873.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1931
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1931
                     /product="bromodomain adjacent to zinc finger domain
                     protein 2A isoform X8"
                     /calculated_mol_wt=213885
     Region          <411..>543
                     /region_name="PRK10856"
                     /note="cytoskeleton protein RodZ"
                     /db_xref="CDD:236776"
     Region          570..642
                     /region_name="HAT_MBD"
                     /note="Methyl-CpG binding domains (MBD) present in
                     putative chromatin remodelling factor such as BAZ2A; BAZ2A
                     contains a MBD, DDT, PHD-type zinc finger and Bromo domain
                     suggesting that BAZ2A might be associated with histone
                     acetyltransferase (HAT) activity. The...; cd01397"
                     /db_xref="CDD:238691"
     Site            order(582,584,586,593,595,604,607,611)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238691"
     Region          867..932
                     /region_name="DDT"
                     /note="domain in different transcription and chromosome
                     remodeling factors; smart00571"
                     /db_xref="CDD:214726"
     Region          1130..>1185
                     /region_name="WSD"
                     /note="Williams-Beuren syndrome DDT (WSD), D-TOX E motif;
                     pfam15613"
                     /db_xref="CDD:464775"
     Region          <1346..1449
                     /region_name="PHA03378"
                     /note="EBNA-3B; Provisional"
                     /db_xref="CDD:223065"
     Region          <1458..1492
                     /region_name="WSD"
                     /note="Williams-Beuren syndrome DDT (WSD), D-TOX E motif;
                     pfam15613"
                     /db_xref="CDD:464775"
     Region          1704..1750
                     /region_name="PHD_BAZ2A"
                     /note="PHD finger found in bromodomain adjacent to zinc
                     finger domain protein 2A (BAZ2A); cd15629"
                     /db_xref="CDD:277099"
     Site            order(1711,1714..1715,1717..1721,1739..1742)
                     /site_type="other"
                     /note="H3 histone binding site [polypeptide binding]"
                     /db_xref="CDD:277099"
     Region          1824..1920
                     /region_name="Bromo_BAZ2A_B_like"
                     /note="Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo
                     adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were
                     identified as a novel human bromodomain gene by cDNA
                     library screening. BAZ2A is also known as Tip5
                     (Transcription termination factor I-interacting...;
                     cd05503"
                     /db_xref="CDD:99935"
     Site            order(1848,1853,1856,1895,1899,1905)
                     /site_type="active"
                     /note="acetyllysine binding site [active]"
                     /db_xref="CDD:99935"
     CDS             1..1931
                     /gene="BAZ2A"
                     /gene_synonym="TIP5; WALp3"
                     /coded_by="XM_054370873.1:306..6101"
                     /db_xref="GeneID:11176"
                     /db_xref="HGNC:HGNC:962"
                     /db_xref="MIM:605682"
ORIGIN      
        1 mevacilhtr ggvqktgerr emeandhfnf tglppapaas glkpspssge glytngspmn
       61 fpqqgkslng dvnvnglstv shtttsgiln saphssstsh lhhpsvaydc lwnysqypsa
      121 npgsnlkdpp llsqfsggqy plngilggsr qpsspshntn lragsqefwa ngtqspmgln
      181 fdsqelydsf pdqnfevmpn gppsfftspq tspmlgssiq tfapsqevgs gihpdeaaek
      241 emtsvvaeng tglvgslele eeqpelkmcg yngsvpsves lhqevsvlvp dptvsclddp
      301 shlpdqledt pilsedslep fnslapepvs gglygiddte lmgaedklpl edspvisald
      361 cpslnnataf slladdsqts tsifasptsp pvlgesvlqd nsfdlnngsd aeqeemetqs
      421 sdfppsltqp apdqsstiql hpatspavsp ttspavslvv spaaspeisp evcpaastvv
      481 spavfsvvsp assavlpavs levpltasvt spkaspvtsp aaafptaspa nkdvssflet
      541 tadveeitge gltasgsgdv mrrriatpee vrlplqhgwr revrikkgsh rwqgetwyyg
      601 pcgkrmkqfp evikylsrnv vhsvrrehfs fsprmpvgdf feerdtpegl qwvqlsaeei
      661 psriqaitgk rgrprnteka ktkevpkvkr grgrppkvki tellnktdnr plkkleaqet
      721 lneedkakia kskkkmrqkv qrgecqttiq gqarnkrkqe tkslkqkeak kkskaekekg
      781 ktkqeklkek vkrekkekvk mkekeevtka kpackadktl atqrrleerq rqqmileemk
      841 kptedmcltd hqplpdfsrv pgltlpsgaf sdcltivefl hsfgkvlgfd pakdvpslgv
      901 lqegllcqgd slgevqdllv rllkaalhdp gfpsycqslk ilgekvseip ltrdnvseil
      961 rcflmaygve palcdrlrtq pfqaqppqqk aavlaflvhe lngstliine idktlesmss
     1021 yrknkwiveg rlrrlktvla krtgrsevem egpeeclgrr rssrimeets gmeeeeeees
     1081 iaavpgrrgr rdgevdatas sipelerqie klskrqlffr kkllhssqml ravslgqdry
     1141 rrrywvlpyl agifvegteg nlvpeevikk etdslkvaah aslnpalfsm kmelagsntt
     1201 assparargr prktkpgsmq prhlkspvrg qdseqpqaql qpeaqlhapa qpqpqlqlql
     1261 qshkgfleqe gsplslgqsq hdlsqsafls wlsqtqshss llsssvltpd sspgkldpap
     1321 sqppeepepd eaesspdpqa lwfnisaqmp cnaaptpppa vsedqptpsp qqlasskpmn
     1381 rpsaanpcsp vqfsstplag lapkrragdp gempqsptgl gqpkrrgrpp skffkqmeqr
     1441 yltqltaqpv ppemcsgwww irdpemldam lkalhprgir ekalhkhlnk hrdflqevcl
     1501 rpsadpifep rqlpafqegi mswspkekty etdlavlqwv eeleqrvims dlqirgwtcp
     1561 spdstredla ycehlsdsqe ditwrgrgre glapqrkttn pldlavmrla aleqnverry
     1621 lreplwpthe vvlekallst pngapegttt eisplspsrs yeitprirvw rqtlercrsa
     1681 aqvclclgql ersiaweksv nkvtclvcrk gdndeflllc dgcdrgchiy chrpkmeavp
     1741 egdwfctvcl aqqvegeftq kpgfpkrgqk rksgyslnfs egdgrrrrvl lrgrespaag
     1801 pryseeglsp skrrrlsmrn hhsdltfcei ilmemeshda awpflepvnp rlvsgyrrii
     1861 knpmdfstmr erllrggyts seefaadall vfdncqtfne ddsevgkagh imrrffesrw
     1921 eefyqgkqan l
//
LOCUS       XP_054226849            1931 aa            linear   PRI 05-AUG-2025
DEFINITION  bromodomain adjacent to zinc finger domain protein 2A isoform X8
            [Homo sapiens].
ACCESSION   XP_054226849
VERSION     XP_054226849.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370874.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1931
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1931
                     /product="bromodomain adjacent to zinc finger domain
                     protein 2A isoform X8"
                     /calculated_mol_wt=213885
     Region          <411..>543
                     /region_name="PRK10856"
                     /note="cytoskeleton protein RodZ"
                     /db_xref="CDD:236776"
     Region          570..642
                     /region_name="HAT_MBD"
                     /note="Methyl-CpG binding domains (MBD) present in
                     putative chromatin remodelling factor such as BAZ2A; BAZ2A
                     contains a MBD, DDT, PHD-type zinc finger and Bromo domain
                     suggesting that BAZ2A might be associated with histone
                     acetyltransferase (HAT) activity. The...; cd01397"
                     /db_xref="CDD:238691"
     Site            order(582,584,586,593,595,604,607,611)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238691"
     Region          867..932
                     /region_name="DDT"
                     /note="domain in different transcription and chromosome
                     remodeling factors; smart00571"
                     /db_xref="CDD:214726"
     Region          1130..>1185
                     /region_name="WSD"
                     /note="Williams-Beuren syndrome DDT (WSD), D-TOX E motif;
                     pfam15613"
                     /db_xref="CDD:464775"
     Region          <1346..1449
                     /region_name="PHA03378"
                     /note="EBNA-3B; Provisional"
                     /db_xref="CDD:223065"
     Region          <1458..1492
                     /region_name="WSD"
                     /note="Williams-Beuren syndrome DDT (WSD), D-TOX E motif;
                     pfam15613"
                     /db_xref="CDD:464775"
     Region          1704..1750
                     /region_name="PHD_BAZ2A"
                     /note="PHD finger found in bromodomain adjacent to zinc
                     finger domain protein 2A (BAZ2A); cd15629"
                     /db_xref="CDD:277099"
     Site            order(1711,1714..1715,1717..1721,1739..1742)
                     /site_type="other"
                     /note="H3 histone binding site [polypeptide binding]"
                     /db_xref="CDD:277099"
     Region          1824..1920
                     /region_name="Bromo_BAZ2A_B_like"
                     /note="Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo
                     adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were
                     identified as a novel human bromodomain gene by cDNA
                     library screening. BAZ2A is also known as Tip5
                     (Transcription termination factor I-interacting...;
                     cd05503"
                     /db_xref="CDD:99935"
     Site            order(1848,1853,1856,1895,1899,1905)
                     /site_type="active"
                     /note="acetyllysine binding site [active]"
                     /db_xref="CDD:99935"
     CDS             1..1931
                     /gene="BAZ2A"
                     /gene_synonym="TIP5; WALp3"
                     /coded_by="XM_054370874.1:432..6227"
                     /db_xref="GeneID:11176"
                     /db_xref="HGNC:HGNC:962"
                     /db_xref="MIM:605682"
ORIGIN      
        1 mevacilhtr ggvqktgerr emeandhfnf tglppapaas glkpspssge glytngspmn
       61 fpqqgkslng dvnvnglstv shtttsgiln saphssstsh lhhpsvaydc lwnysqypsa
      121 npgsnlkdpp llsqfsggqy plngilggsr qpsspshntn lragsqefwa ngtqspmgln
      181 fdsqelydsf pdqnfevmpn gppsfftspq tspmlgssiq tfapsqevgs gihpdeaaek
      241 emtsvvaeng tglvgslele eeqpelkmcg yngsvpsves lhqevsvlvp dptvsclddp
      301 shlpdqledt pilsedslep fnslapepvs gglygiddte lmgaedklpl edspvisald
      361 cpslnnataf slladdsqts tsifasptsp pvlgesvlqd nsfdlnngsd aeqeemetqs
      421 sdfppsltqp apdqsstiql hpatspavsp ttspavslvv spaaspeisp evcpaastvv
      481 spavfsvvsp assavlpavs levpltasvt spkaspvtsp aaafptaspa nkdvssflet
      541 tadveeitge gltasgsgdv mrrriatpee vrlplqhgwr revrikkgsh rwqgetwyyg
      601 pcgkrmkqfp evikylsrnv vhsvrrehfs fsprmpvgdf feerdtpegl qwvqlsaeei
      661 psriqaitgk rgrprnteka ktkevpkvkr grgrppkvki tellnktdnr plkkleaqet
      721 lneedkakia kskkkmrqkv qrgecqttiq gqarnkrkqe tkslkqkeak kkskaekekg
      781 ktkqeklkek vkrekkekvk mkekeevtka kpackadktl atqrrleerq rqqmileemk
      841 kptedmcltd hqplpdfsrv pgltlpsgaf sdcltivefl hsfgkvlgfd pakdvpslgv
      901 lqegllcqgd slgevqdllv rllkaalhdp gfpsycqslk ilgekvseip ltrdnvseil
      961 rcflmaygve palcdrlrtq pfqaqppqqk aavlaflvhe lngstliine idktlesmss
     1021 yrknkwiveg rlrrlktvla krtgrsevem egpeeclgrr rssrimeets gmeeeeeees
     1081 iaavpgrrgr rdgevdatas sipelerqie klskrqlffr kkllhssqml ravslgqdry
     1141 rrrywvlpyl agifvegteg nlvpeevikk etdslkvaah aslnpalfsm kmelagsntt
     1201 assparargr prktkpgsmq prhlkspvrg qdseqpqaql qpeaqlhapa qpqpqlqlql
     1261 qshkgfleqe gsplslgqsq hdlsqsafls wlsqtqshss llsssvltpd sspgkldpap
     1321 sqppeepepd eaesspdpqa lwfnisaqmp cnaaptpppa vsedqptpsp qqlasskpmn
     1381 rpsaanpcsp vqfsstplag lapkrragdp gempqsptgl gqpkrrgrpp skffkqmeqr
     1441 yltqltaqpv ppemcsgwww irdpemldam lkalhprgir ekalhkhlnk hrdflqevcl
     1501 rpsadpifep rqlpafqegi mswspkekty etdlavlqwv eeleqrvims dlqirgwtcp
     1561 spdstredla ycehlsdsqe ditwrgrgre glapqrkttn pldlavmrla aleqnverry
     1621 lreplwpthe vvlekallst pngapegttt eisplspsrs yeitprirvw rqtlercrsa
     1681 aqvclclgql ersiaweksv nkvtclvcrk gdndeflllc dgcdrgchiy chrpkmeavp
     1741 egdwfctvcl aqqvegeftq kpgfpkrgqk rksgyslnfs egdgrrrrvl lrgrespaag
     1801 pryseeglsp skrrrlsmrn hhsdltfcei ilmemeshda awpflepvnp rlvsgyrrii
     1861 knpmdfstmr erllrggyts seefaadall vfdncqtfne ddsevgkagh imrrffesrw
     1921 eefyqgkqan l
//
LOCUS       XP_054226850            1875 aa            linear   PRI 05-AUG-2025
DEFINITION  bromodomain adjacent to zinc finger domain protein 2A isoform X26
            [Homo sapiens].
ACCESSION   XP_054226850
VERSION     XP_054226850.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370875.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1875
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1875
                     /product="bromodomain adjacent to zinc finger domain
                     protein 2A isoform X26"
                     /calculated_mol_wt=207946
     Region          <362..>494
                     /region_name="PRK10856"
                     /note="cytoskeleton protein RodZ"
                     /db_xref="CDD:236776"
     Region          521..593
                     /region_name="HAT_MBD"
                     /note="Methyl-CpG binding domains (MBD) present in
                     putative chromatin remodelling factor such as BAZ2A; BAZ2A
                     contains a MBD, DDT, PHD-type zinc finger and Bromo domain
                     suggesting that BAZ2A might be associated with histone
                     acetyltransferase (HAT) activity. The...; cd01397"
                     /db_xref="CDD:238691"
     Site            order(533,535,537,544,546,555,558,562)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238691"
     Region          818..883
                     /region_name="DDT"
                     /note="domain in different transcription and chromosome
                     remodeling factors; smart00571"
                     /db_xref="CDD:214726"
     Region          1081..>1136
                     /region_name="WSD"
                     /note="Williams-Beuren syndrome DDT (WSD), D-TOX E motif;
                     pfam15613"
                     /db_xref="CDD:464775"
     Region          <1297..1400
                     /region_name="PHA03378"
                     /note="EBNA-3B; Provisional"
                     /db_xref="CDD:223065"
     Region          <1409..1443
                     /region_name="WSD"
                     /note="Williams-Beuren syndrome DDT (WSD), D-TOX E motif;
                     pfam15613"
                     /db_xref="CDD:464775"
     Region          1648..1694
                     /region_name="PHD_BAZ2A"
                     /note="PHD finger found in bromodomain adjacent to zinc
                     finger domain protein 2A (BAZ2A); cd15629"
                     /db_xref="CDD:277099"
     Site            order(1655,1658..1659,1661..1665,1683..1686)
                     /site_type="other"
                     /note="H3 histone binding site [polypeptide binding]"
                     /db_xref="CDD:277099"
     Region          1768..1864
                     /region_name="Bromo_BAZ2A_B_like"
                     /note="Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo
                     adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were
                     identified as a novel human bromodomain gene by cDNA
                     library screening. BAZ2A is also known as Tip5
                     (Transcription termination factor I-interacting...;
                     cd05503"
                     /db_xref="CDD:99935"
     Site            order(1792,1797,1800,1839,1843,1849)
                     /site_type="active"
                     /note="acetyllysine binding site [active]"
                     /db_xref="CDD:99935"
     CDS             1..1875
                     /gene="BAZ2A"
                     /gene_synonym="TIP5; WALp3"
                     /coded_by="XM_054370875.1:175..5802"
                     /db_xref="GeneID:11176"
                     /db_xref="HGNC:HGNC:962"
                     /db_xref="MIM:605682"
ORIGIN      
        1 memeandhfn ftglppapaa sglkpspssg eglytngspm nfpqqgksln gdvnvnglst
       61 vshtttsgil nsaphsssts hlhhpsvayd clwnysqyps anpgsnlkdp pllsqfsggq
      121 yplngilggs rqpsspshnt nlragsqefw angtqspmgl nfdsqelyds fpdqnfeevg
      181 sgihpdeaae kemtsvvaen gtglvgslel eeeqpelkmc gyngsvpsve slhqevsvlv
      241 pdptvscldd pshlpdqled tpilsedsle pfnslapepv sgglygiddt elmgaedklp
      301 ledspvisal dcpslnnata fslladdsqt stsifaspts ppvlgesvlq dnsfdlnngs
      361 daeqeemetq ssdfppsltq papdqsstiq lhpatspavs pttspavslv vspaaspeis
      421 pevcpaastv vspavfsvvs passavlpav slevpltasv tspkaspvts paaafptasp
      481 ankdvssfle ttadveeitg egltasgsgd vmrrriatpe evrlplqhgw rrevrikkgs
      541 hrwqgetwyy gpcgkrmkqf pevikylsrn vvhsvrrehf sfsprmpvgd ffeerdtpeg
      601 lqwvqlsaee ipsriqaitg krgrprntek aktkevpkvk rgrgrppkvk itellnktdn
      661 rplkkleaqe tlneedkaki akskkkmrqk vqrgecqtti qgqarnkrkq etkslkqkea
      721 kkkskaekek gktkqeklke kvkrekkekv kmkekeevtk akpackadkt latqrrleer
      781 qrqqmileem kkptedmclt dhqplpdfsr vpgltlpsga fsdcltivef lhsfgkvlgf
      841 dpakdvpslg vlqegllcqg dslgevqdll vrllkaalhd pgfpsycqsl kilgekvsei
      901 pltrdnvsei lrcflmaygv epalcdrlrt qpfqaqppqq kaavlaflvh elngstliin
      961 eidktlesms syrknkwive grlrrlktvl akrtgrseve megpeeclgr rrssrimeet
     1021 sgmeeeeeee siaavpgrrg rrdgevdata ssipelerqi eklskrqlff rkkllhssqm
     1081 lravslgqdr yrrrywvlpy lagifvegte gnlvpeevik ketdslkvaa haslnpalfs
     1141 mkmelagsnt tasspararg rprktkpgsm qprhlkspvr gqdseqpqaq lqpeaqlhap
     1201 aqpqpqlqlq lqshkgfleq egsplslgqs qhdlsqsafl swlsqtqshs sllsssvltp
     1261 dsspgkldpa psqppeepep deaesspdpq alwfnisaqm pcnaaptppp avsedqptps
     1321 pqqlasskpm nrpsaanpcs pvqfsstpla glapkrragd pgempqsptg lgqpkrrgrp
     1381 pskffkqmeq ryltqltaqp vppemcsgww wirdpemlda mlkalhprgi rekalhkhln
     1441 khrdflqevc lrpsadpife prqlpafqeg imswspkekt yetdlavlqw veeleqrvim
     1501 sdlqirgwtc pspdstredl aycehlsdsq editwrgrgr eglapqrktt npldlavmrl
     1561 aaleqnverr ylreplwpth evvlekalls tpngapegtt teisyeitpr irvwrqtler
     1621 crsaaqvclc lgqlersiaw eksvnkvtcl vcrkgdndef lllcdgcdrg chiychrpkm
     1681 eavpegdwfc tvclaqqveg eftqkpgfpk rgqkrksgys lnfsegdgrr rrvllrgres
     1741 paagprysee glspskrrrl smrnhhsdlt fceiilmeme shdaawpfle pvnprlvsgy
     1801 rriiknpmdf stmrerllrg gytsseefaa dallvfdncq tfneddsevg kaghimrrff
     1861 esrweefyqg kqanl
//
LOCUS       XP_054226851            1873 aa            linear   PRI 05-AUG-2025
DEFINITION  bromodomain adjacent to zinc finger domain protein 2A isoform X10
            [Homo sapiens].
ACCESSION   XP_054226851
VERSION     XP_054226851.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370876.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1873
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1873
                     /product="bromodomain adjacent to zinc finger domain
                     protein 2A isoform X10"
                     /calculated_mol_wt=207686
     Region          <360..>492
                     /region_name="PRK10856"
                     /note="cytoskeleton protein RodZ"
                     /db_xref="CDD:236776"
     Region          519..591
                     /region_name="HAT_MBD"
                     /note="Methyl-CpG binding domains (MBD) present in
                     putative chromatin remodelling factor such as BAZ2A; BAZ2A
                     contains a MBD, DDT, PHD-type zinc finger and Bromo domain
                     suggesting that BAZ2A might be associated with histone
                     acetyltransferase (HAT) activity. The...; cd01397"
                     /db_xref="CDD:238691"
     Site            order(531,533,535,542,544,553,556,560)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238691"
     Region          816..881
                     /region_name="DDT"
                     /note="domain in different transcription and chromosome
                     remodeling factors; smart00571"
                     /db_xref="CDD:214726"
     Region          1079..>1134
                     /region_name="WSD"
                     /note="Williams-Beuren syndrome DDT (WSD), D-TOX E motif;
                     pfam15613"
                     /db_xref="CDD:464775"
     Region          <1295..1398
                     /region_name="PHA03378"
                     /note="EBNA-3B; Provisional"
                     /db_xref="CDD:223065"
     Region          <1407..1441
                     /region_name="WSD"
                     /note="Williams-Beuren syndrome DDT (WSD), D-TOX E motif;
                     pfam15613"
                     /db_xref="CDD:464775"
     Region          1646..1692
                     /region_name="PHD_BAZ2A"
                     /note="PHD finger found in bromodomain adjacent to zinc
                     finger domain protein 2A (BAZ2A); cd15629"
                     /db_xref="CDD:277099"
     Site            order(1653,1656..1657,1659..1663,1681..1684)
                     /site_type="other"
                     /note="H3 histone binding site [polypeptide binding]"
                     /db_xref="CDD:277099"
     Region          1766..1862
                     /region_name="Bromo_BAZ2A_B_like"
                     /note="Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo
                     adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were
                     identified as a novel human bromodomain gene by cDNA
                     library screening. BAZ2A is also known as Tip5
                     (Transcription termination factor I-interacting...;
                     cd05503"
                     /db_xref="CDD:99935"
     Site            order(1790,1795,1798,1837,1841,1847)
                     /site_type="active"
                     /note="acetyllysine binding site [active]"
                     /db_xref="CDD:99935"
     CDS             1..1873
                     /gene="BAZ2A"
                     /gene_synonym="TIP5; WALp3"
                     /coded_by="XM_054370876.1:77..5698"
                     /db_xref="GeneID:11176"
                     /db_xref="HGNC:HGNC:962"
                     /db_xref="MIM:605682"
ORIGIN      
        1 meandhfnft glppapaasg lkpspssgeg lytngspmnf pqqgkslngd vnvnglstvs
       61 htttsgilns aphssstshl hhpsvaydcl wnysqypsan pgsnlkdppl lsqfsggqyp
      121 lngilggsrq psspshntnl ragsqefwan gtqspmglnf dsqelydsfp dqnfeevgsg
      181 ihpdeaaeke mtsvvaengt glvgslelee eqpelkmcgy ngsvpsvesl hqevsvlvpd
      241 ptvsclddps hlpdqledtp ilsedslepf nslapepvsg glygiddtel mgaedklple
      301 dspvisaldc pslnnatafs lladdsqtst sifasptspp vlgesvlqdn sfdlnngsda
      361 eqeemetqss dfppsltqpa pdqsstiqlh patspavspt tspavslvvs paaspeispe
      421 vcpaastvvs pavfsvvspa ssavlpavsl evpltasvts pkaspvtspa aafptaspan
      481 kdvssflett adveeitgeg ltasgsgdvm rrriatpeev rlplqhgwrr evrikkgshr
      541 wqgetwyygp cgkrmkqfpe vikylsrnvv hsvrrehfsf sprmpvgdff eerdtpeglq
      601 wvqlsaeeip sriqaitgkr grprntekak tkevpkvkrg rgrppkvkit ellnktdnrp
      661 lkkleaqetl needkakiak skkkmrqkvq rgecqttiqg qarnkrkqet kslkqkeakk
      721 kskaekekgk tkqeklkekv krekkekvkm kekeevtkak packadktla tqrrleerqr
      781 qqmileemkk ptedmcltdh qplpdfsrvp gltlpsgafs dcltiveflh sfgkvlgfdp
      841 akdvpslgvl qegllcqgds lgevqdllvr llkaalhdpg fpsycqslki lgekvseipl
      901 trdnvseilr cflmaygvep alcdrlrtqp fqaqppqqka avlaflvhel ngstliinei
      961 dktlesmssy rknkwivegr lrrlktvlak rtgrseveme gpeeclgrrr ssrimeetsg
     1021 meeeeeeesi aavpgrrgrr dgevdatass ipelerqiek lskrqlffrk kllhssqmlr
     1081 avslgqdryr rrywvlpyla gifvegtegn lvpeevikke tdslkvaaha slnpalfsmk
     1141 melagsntta ssparargrp rktkpgsmqp rhlkspvrgq dseqpqaqlq peaqlhapaq
     1201 pqpqlqlqlq shkgfleqeg splslgqsqh dlsqsaflsw lsqtqshssl lsssvltpds
     1261 spgkldpaps qppeepepde aesspdpqal wfnisaqmpc naaptpppav sedqptpspq
     1321 qlasskpmnr psaanpcspv qfsstplagl apkrragdpg empqsptglg qpkrrgrpps
     1381 kffkqmeqry ltqltaqpvp pemcsgwwwi rdpemldaml kalhprgire kalhkhlnkh
     1441 rdflqevclr psadpifepr qlpafqegim swspkektye tdlavlqwve eleqrvimsd
     1501 lqirgwtcps pdstredlay cehlsdsqed itwrgrgreg lapqrkttnp ldlavmrlaa
     1561 leqnverryl replwpthev vlekallstp ngapegttte isyeitprir vwrqtlercr
     1621 saaqvclclg qlersiawek svnkvtclvc rkgdndefll lcdgcdrgch iychrpkmea
     1681 vpegdwfctv claqqvegef tqkpgfpkrg qkrksgysln fsegdgrrrr vllrgrespa
     1741 agpryseegl spskrrrlsm rnhhsdltfc eiilmemesh daawpflepv nprlvsgyrr
     1801 iiknpmdfst mrerllrggy tsseefaada llvfdncqtf neddsevgka ghimrrffes
     1861 rweefyqgkq anl
//
LOCUS       XP_054226852            1924 aa            linear   PRI 05-AUG-2025
DEFINITION  bromodomain adjacent to zinc finger domain protein 2A isoform X11
            [Homo sapiens].
ACCESSION   XP_054226852
VERSION     XP_054226852.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370877.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1924
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1924
                     /product="bromodomain adjacent to zinc finger domain
                     protein 2A isoform X11"
                     /calculated_mol_wt=213160
     Region          <411..>543
                     /region_name="PRK10856"
                     /note="cytoskeleton protein RodZ"
                     /db_xref="CDD:236776"
     Region          570..642
                     /region_name="HAT_MBD"
                     /note="Methyl-CpG binding domains (MBD) present in
                     putative chromatin remodelling factor such as BAZ2A; BAZ2A
                     contains a MBD, DDT, PHD-type zinc finger and Bromo domain
                     suggesting that BAZ2A might be associated with histone
                     acetyltransferase (HAT) activity. The...; cd01397"
                     /db_xref="CDD:238691"
     Site            order(582,584,586,593,595,604,607,611)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238691"
     Region          867..932
                     /region_name="DDT"
                     /note="domain in different transcription and chromosome
                     remodeling factors; smart00571"
                     /db_xref="CDD:214726"
     Region          1130..>1185
                     /region_name="WSD"
                     /note="Williams-Beuren syndrome DDT (WSD), D-TOX E motif;
                     pfam15613"
                     /db_xref="CDD:464775"
     Region          <1346..1449
                     /region_name="PHA03378"
                     /note="EBNA-3B; Provisional"
                     /db_xref="CDD:223065"
     Region          <1458..1492
                     /region_name="WSD"
                     /note="Williams-Beuren syndrome DDT (WSD), D-TOX E motif;
                     pfam15613"
                     /db_xref="CDD:464775"
     Region          1697..1743
                     /region_name="PHD_BAZ2A"
                     /note="PHD finger found in bromodomain adjacent to zinc
                     finger domain protein 2A (BAZ2A); cd15629"
                     /db_xref="CDD:277099"
     Site            order(1704,1707..1708,1710..1714,1732..1735)
                     /site_type="other"
                     /note="H3 histone binding site [polypeptide binding]"
                     /db_xref="CDD:277099"
     Region          1817..1913
                     /region_name="Bromo_BAZ2A_B_like"
                     /note="Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo
                     adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were
                     identified as a novel human bromodomain gene by cDNA
                     library screening. BAZ2A is also known as Tip5
                     (Transcription termination factor I-interacting...;
                     cd05503"
                     /db_xref="CDD:99935"
     Site            order(1841,1846,1849,1888,1892,1898)
                     /site_type="active"
                     /note="acetyllysine binding site [active]"
                     /db_xref="CDD:99935"
     CDS             1..1924
                     /gene="BAZ2A"
                     /gene_synonym="TIP5; WALp3"
                     /coded_by="XM_054370877.1:372..6146"
                     /db_xref="GeneID:11176"
                     /db_xref="HGNC:HGNC:962"
                     /db_xref="MIM:605682"
ORIGIN      
        1 mevacilhtr ggvqktgerr emeandhfnf tglppapaas glkpspssge glytngspmn
       61 fpqqgkslng dvnvnglstv shtttsgiln saphssstsh lhhpsvaydc lwnysqypsa
      121 npgsnlkdpp llsqfsggqy plngilggsr qpsspshntn lragsqefwa ngtqspmgln
      181 fdsqelydsf pdqnfevmpn gppsfftspq tspmlgssiq tfapsqevgs gihpdeaaek
      241 emtsvvaeng tglvgslele eeqpelkmcg yngsvpsves lhqevsvlvp dptvsclddp
      301 shlpdqledt pilsedslep fnslapepvs gglygiddte lmgaedklpl edspvisald
      361 cpslnnataf slladdsqts tsifasptsp pvlgesvlqd nsfdlnngsd aeqeemetqs
      421 sdfppsltqp apdqsstiql hpatspavsp ttspavslvv spaaspeisp evcpaastvv
      481 spavfsvvsp assavlpavs levpltasvt spkaspvtsp aaafptaspa nkdvssflet
      541 tadveeitge gltasgsgdv mrrriatpee vrlplqhgwr revrikkgsh rwqgetwyyg
      601 pcgkrmkqfp evikylsrnv vhsvrrehfs fsprmpvgdf feerdtpegl qwvqlsaeei
      661 psriqaitgk rgrprnteka ktkevpkvkr grgrppkvki tellnktdnr plkkleaqet
      721 lneedkakia kskkkmrqkv qrgecqttiq gqarnkrkqe tkslkqkeak kkskaekekg
      781 ktkqeklkek vkrekkekvk mkekeevtka kpackadktl atqrrleerq rqqmileemk
      841 kptedmcltd hqplpdfsrv pgltlpsgaf sdcltivefl hsfgkvlgfd pakdvpslgv
      901 lqegllcqgd slgevqdllv rllkaalhdp gfpsycqslk ilgekvseip ltrdnvseil
      961 rcflmaygve palcdrlrtq pfqaqppqqk aavlaflvhe lngstliine idktlesmss
     1021 yrknkwiveg rlrrlktvla krtgrsevem egpeeclgrr rssrimeets gmeeeeeees
     1081 iaavpgrrgr rdgevdatas sipelerqie klskrqlffr kkllhssqml ravslgqdry
     1141 rrrywvlpyl agifvegteg nlvpeevikk etdslkvaah aslnpalfsm kmelagsntt
     1201 assparargr prktkpgsmq prhlkspvrg qdseqpqaql qpeaqlhapa qpqpqlqlql
     1261 qshkgfleqe gsplslgqsq hdlsqsafls wlsqtqshss llsssvltpd sspgkldpap
     1321 sqppeepepd eaesspdpqa lwfnisaqmp cnaaptpppa vsedqptpsp qqlasskpmn
     1381 rpsaanpcsp vqfsstplag lapkrragdp gempqsptgl gqpkrrgrpp skffkqmeqr
     1441 yltqltaqpv ppemcsgwww irdpemldam lkalhprgir ekalhkhlnk hrdflqevcl
     1501 rpsadpifep rqlpafqegi mswspkekty etdlavlqwv eeleqrvims dlqirgwtcp
     1561 spdstredla ycehlsdsqe ditwrgrgre glapqrkttn pldlavmrla aleqnverry
     1621 lreplwpthe vvlekallst pngapegttt eisyeitpri rvwrqtlerc rsaaqvclcl
     1681 gqlersiawe ksvnkvtclv crkgdndefl llcdgcdrgc hiychrpkme avpegdwfct
     1741 vclaqqvege ftqkpgfpkr gqkrksgysl nfsegdgrrr rvllrgresp aagpryseeg
     1801 lspskrrrls mrnhhsdltf ceiilmemes hdaawpflep vnprlvsgyr riiknpmdfs
     1861 tmrerllrgg ytsseefaad allvfdncqt fneddsevgk aghimrrffe srweefyqgk
     1921 qanl
//
LOCUS       XP_054226853            1924 aa            linear   PRI 05-AUG-2025
DEFINITION  bromodomain adjacent to zinc finger domain protein 2A isoform X11
            [Homo sapiens].
ACCESSION   XP_054226853
VERSION     XP_054226853.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370878.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1924
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1924
                     /product="bromodomain adjacent to zinc finger domain
                     protein 2A isoform X11"
                     /calculated_mol_wt=213160
     Region          <411..>543
                     /region_name="PRK10856"
                     /note="cytoskeleton protein RodZ"
                     /db_xref="CDD:236776"
     Region          570..642
                     /region_name="HAT_MBD"
                     /note="Methyl-CpG binding domains (MBD) present in
                     putative chromatin remodelling factor such as BAZ2A; BAZ2A
                     contains a MBD, DDT, PHD-type zinc finger and Bromo domain
                     suggesting that BAZ2A might be associated with histone
                     acetyltransferase (HAT) activity. The...; cd01397"
                     /db_xref="CDD:238691"
     Site            order(582,584,586,593,595,604,607,611)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238691"
     Region          867..932
                     /region_name="DDT"
                     /note="domain in different transcription and chromosome
                     remodeling factors; smart00571"
                     /db_xref="CDD:214726"
     Region          1130..>1185
                     /region_name="WSD"
                     /note="Williams-Beuren syndrome DDT (WSD), D-TOX E motif;
                     pfam15613"
                     /db_xref="CDD:464775"
     Region          <1346..1449
                     /region_name="PHA03378"
                     /note="EBNA-3B; Provisional"
                     /db_xref="CDD:223065"
     Region          <1458..1492
                     /region_name="WSD"
                     /note="Williams-Beuren syndrome DDT (WSD), D-TOX E motif;
                     pfam15613"
                     /db_xref="CDD:464775"
     Region          1697..1743
                     /region_name="PHD_BAZ2A"
                     /note="PHD finger found in bromodomain adjacent to zinc
                     finger domain protein 2A (BAZ2A); cd15629"
                     /db_xref="CDD:277099"
     Site            order(1704,1707..1708,1710..1714,1732..1735)
                     /site_type="other"
                     /note="H3 histone binding site [polypeptide binding]"
                     /db_xref="CDD:277099"
     Region          1817..1913
                     /region_name="Bromo_BAZ2A_B_like"
                     /note="Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo
                     adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were
                     identified as a novel human bromodomain gene by cDNA
                     library screening. BAZ2A is also known as Tip5
                     (Transcription termination factor I-interacting...;
                     cd05503"
                     /db_xref="CDD:99935"
     Site            order(1841,1846,1849,1888,1892,1898)
                     /site_type="active"
                     /note="acetyllysine binding site [active]"
                     /db_xref="CDD:99935"
     CDS             1..1924
                     /gene="BAZ2A"
                     /gene_synonym="TIP5; WALp3"
                     /coded_by="XM_054370878.1:306..6080"
                     /db_xref="GeneID:11176"
                     /db_xref="HGNC:HGNC:962"
                     /db_xref="MIM:605682"
ORIGIN      
        1 mevacilhtr ggvqktgerr emeandhfnf tglppapaas glkpspssge glytngspmn
       61 fpqqgkslng dvnvnglstv shtttsgiln saphssstsh lhhpsvaydc lwnysqypsa
      121 npgsnlkdpp llsqfsggqy plngilggsr qpsspshntn lragsqefwa ngtqspmgln
      181 fdsqelydsf pdqnfevmpn gppsfftspq tspmlgssiq tfapsqevgs gihpdeaaek
      241 emtsvvaeng tglvgslele eeqpelkmcg yngsvpsves lhqevsvlvp dptvsclddp
      301 shlpdqledt pilsedslep fnslapepvs gglygiddte lmgaedklpl edspvisald
      361 cpslnnataf slladdsqts tsifasptsp pvlgesvlqd nsfdlnngsd aeqeemetqs
      421 sdfppsltqp apdqsstiql hpatspavsp ttspavslvv spaaspeisp evcpaastvv
      481 spavfsvvsp assavlpavs levpltasvt spkaspvtsp aaafptaspa nkdvssflet
      541 tadveeitge gltasgsgdv mrrriatpee vrlplqhgwr revrikkgsh rwqgetwyyg
      601 pcgkrmkqfp evikylsrnv vhsvrrehfs fsprmpvgdf feerdtpegl qwvqlsaeei
      661 psriqaitgk rgrprnteka ktkevpkvkr grgrppkvki tellnktdnr plkkleaqet
      721 lneedkakia kskkkmrqkv qrgecqttiq gqarnkrkqe tkslkqkeak kkskaekekg
      781 ktkqeklkek vkrekkekvk mkekeevtka kpackadktl atqrrleerq rqqmileemk
      841 kptedmcltd hqplpdfsrv pgltlpsgaf sdcltivefl hsfgkvlgfd pakdvpslgv
      901 lqegllcqgd slgevqdllv rllkaalhdp gfpsycqslk ilgekvseip ltrdnvseil
      961 rcflmaygve palcdrlrtq pfqaqppqqk aavlaflvhe lngstliine idktlesmss
     1021 yrknkwiveg rlrrlktvla krtgrsevem egpeeclgrr rssrimeets gmeeeeeees
     1081 iaavpgrrgr rdgevdatas sipelerqie klskrqlffr kkllhssqml ravslgqdry
     1141 rrrywvlpyl agifvegteg nlvpeevikk etdslkvaah aslnpalfsm kmelagsntt
     1201 assparargr prktkpgsmq prhlkspvrg qdseqpqaql qpeaqlhapa qpqpqlqlql
     1261 qshkgfleqe gsplslgqsq hdlsqsafls wlsqtqshss llsssvltpd sspgkldpap
     1321 sqppeepepd eaesspdpqa lwfnisaqmp cnaaptpppa vsedqptpsp qqlasskpmn
     1381 rpsaanpcsp vqfsstplag lapkrragdp gempqsptgl gqpkrrgrpp skffkqmeqr
     1441 yltqltaqpv ppemcsgwww irdpemldam lkalhprgir ekalhkhlnk hrdflqevcl
     1501 rpsadpifep rqlpafqegi mswspkekty etdlavlqwv eeleqrvims dlqirgwtcp
     1561 spdstredla ycehlsdsqe ditwrgrgre glapqrkttn pldlavmrla aleqnverry
     1621 lreplwpthe vvlekallst pngapegttt eisyeitpri rvwrqtlerc rsaaqvclcl
     1681 gqlersiawe ksvnkvtclv crkgdndefl llcdgcdrgc hiychrpkme avpegdwfct
     1741 vclaqqvege ftqkpgfpkr gqkrksgysl nfsegdgrrr rvllrgresp aagpryseeg
     1801 lspskrrrls mrnhhsdltf ceiilmemes hdaawpflep vnprlvsgyr riiknpmdfs
     1861 tmrerllrgg ytsseefaad allvfdncqt fneddsevgk aghimrrffe srweefyqgk
     1921 qanl
//
LOCUS       XP_054226854            1874 aa            linear   PRI 05-AUG-2025
DEFINITION  bromodomain adjacent to zinc finger domain protein 2A isoform X27
            [Homo sapiens].
ACCESSION   XP_054226854
VERSION     XP_054226854.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370879.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1874
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1874
                     /product="bromodomain adjacent to zinc finger domain
                     protein 2A isoform X27"
                     /calculated_mol_wt=207818
     Region          <362..>494
                     /region_name="PRK10856"
                     /note="cytoskeleton protein RodZ"
                     /db_xref="CDD:236776"
     Region          521..593
                     /region_name="HAT_MBD"
                     /note="Methyl-CpG binding domains (MBD) present in
                     putative chromatin remodelling factor such as BAZ2A; BAZ2A
                     contains a MBD, DDT, PHD-type zinc finger and Bromo domain
                     suggesting that BAZ2A might be associated with histone
                     acetyltransferase (HAT) activity. The...; cd01397"
                     /db_xref="CDD:238691"
     Site            order(533,535,537,544,546,555,558,562)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238691"
     Region          818..883
                     /region_name="DDT"
                     /note="domain in different transcription and chromosome
                     remodeling factors; smart00571"
                     /db_xref="CDD:214726"
     Region          1081..>1136
                     /region_name="WSD"
                     /note="Williams-Beuren syndrome DDT (WSD), D-TOX E motif;
                     pfam15613"
                     /db_xref="CDD:464775"
     Region          <1297..1400
                     /region_name="PHA03378"
                     /note="EBNA-3B; Provisional"
                     /db_xref="CDD:223065"
     Region          <1409..1443
                     /region_name="WSD"
                     /note="Williams-Beuren syndrome DDT (WSD), D-TOX E motif;
                     pfam15613"
                     /db_xref="CDD:464775"
     Region          1648..1694
                     /region_name="PHD_BAZ2A"
                     /note="PHD finger found in bromodomain adjacent to zinc
                     finger domain protein 2A (BAZ2A); cd15629"
                     /db_xref="CDD:277099"
     Site            order(1655,1658..1659,1661..1665,1683..1686)
                     /site_type="other"
                     /note="H3 histone binding site [polypeptide binding]"
                     /db_xref="CDD:277099"
     Region          1767..1863
                     /region_name="Bromo_BAZ2A_B_like"
                     /note="Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo
                     adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were
                     identified as a novel human bromodomain gene by cDNA
                     library screening. BAZ2A is also known as Tip5
                     (Transcription termination factor I-interacting...;
                     cd05503"
                     /db_xref="CDD:99935"
     Site            order(1791,1796,1799,1838,1842,1848)
                     /site_type="active"
                     /note="acetyllysine binding site [active]"
                     /db_xref="CDD:99935"
     CDS             1..1874
                     /gene="BAZ2A"
                     /gene_synonym="TIP5; WALp3"
                     /coded_by="XM_054370879.1:175..5799"
                     /db_xref="GeneID:11176"
                     /db_xref="HGNC:HGNC:962"
                     /db_xref="MIM:605682"
ORIGIN      
        1 memeandhfn ftglppapaa sglkpspssg eglytngspm nfpqqgksln gdvnvnglst
       61 vshtttsgil nsaphsssts hlhhpsvayd clwnysqyps anpgsnlkdp pllsqfsggq
      121 yplngilggs rqpsspshnt nlragsqefw angtqspmgl nfdsqelyds fpdqnfeevg
      181 sgihpdeaae kemtsvvaen gtglvgslel eeeqpelkmc gyngsvpsve slhqevsvlv
      241 pdptvscldd pshlpdqled tpilsedsle pfnslapepv sgglygiddt elmgaedklp
      301 ledspvisal dcpslnnata fslladdsqt stsifaspts ppvlgesvlq dnsfdlnngs
      361 daeqeemetq ssdfppsltq papdqsstiq lhpatspavs pttspavslv vspaaspeis
      421 pevcpaastv vspavfsvvs passavlpav slevpltasv tspkaspvts paaafptasp
      481 ankdvssfle ttadveeitg egltasgsgd vmrrriatpe evrlplqhgw rrevrikkgs
      541 hrwqgetwyy gpcgkrmkqf pevikylsrn vvhsvrrehf sfsprmpvgd ffeerdtpeg
      601 lqwvqlsaee ipsriqaitg krgrprntek aktkevpkvk rgrgrppkvk itellnktdn
      661 rplkkleaqe tlneedkaki akskkkmrqk vqrgecqtti qgqarnkrkq etkslkqkea
      721 kkkskaekek gktkqeklke kvkrekkekv kmkekeevtk akpackadkt latqrrleer
      781 qrqqmileem kkptedmclt dhqplpdfsr vpgltlpsga fsdcltivef lhsfgkvlgf
      841 dpakdvpslg vlqegllcqg dslgevqdll vrllkaalhd pgfpsycqsl kilgekvsei
      901 pltrdnvsei lrcflmaygv epalcdrlrt qpfqaqppqq kaavlaflvh elngstliin
      961 eidktlesms syrknkwive grlrrlktvl akrtgrseve megpeeclgr rrssrimeet
     1021 sgmeeeeeee siaavpgrrg rrdgevdata ssipelerqi eklskrqlff rkkllhssqm
     1081 lravslgqdr yrrrywvlpy lagifvegte gnlvpeevik ketdslkvaa haslnpalfs
     1141 mkmelagsnt tasspararg rprktkpgsm qprhlkspvr gqdseqpqaq lqpeaqlhap
     1201 aqpqpqlqlq lqshkgfleq egsplslgqs qhdlsqsafl swlsqtqshs sllsssvltp
     1261 dsspgkldpa psqppeepep deaesspdpq alwfnisaqm pcnaaptppp avsedqptps
     1321 pqqlasskpm nrpsaanpcs pvqfsstpla glapkrragd pgempqsptg lgqpkrrgrp
     1381 pskffkqmeq ryltqltaqp vppemcsgww wirdpemlda mlkalhprgi rekalhkhln
     1441 khrdflqevc lrpsadpife prqlpafqeg imswspkekt yetdlavlqw veeleqrvim
     1501 sdlqirgwtc pspdstredl aycehlsdsq editwrgrgr eglapqrktt npldlavmrl
     1561 aaleqnverr ylreplwpth evvlekalls tpngapegtt teisyeitpr irvwrqtler
     1621 crsaaqvclc lgqlersiaw eksvnkvtcl vcrkgdndef lllcdgcdrg chiychrpkm
     1681 eavpegdwfc tvclaqvege ftqkpgfpkr gqkrksgysl nfsegdgrrr rvllrgresp
     1741 aagpryseeg lspskrrrls mrnhhsdltf ceiilmemes hdaawpflep vnprlvsgyr
     1801 riiknpmdfs tmrerllrgg ytsseefaad allvfdncqt fneddsevgk aghimrrffe
     1861 srweefyqgk qanl
//
LOCUS       XP_054226855            1923 aa            linear   PRI 05-AUG-2025
DEFINITION  bromodomain adjacent to zinc finger domain protein 2A isoform X13
            [Homo sapiens].
ACCESSION   XP_054226855
VERSION     XP_054226855.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370880.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1923
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1923
                     /product="bromodomain adjacent to zinc finger domain
                     protein 2A isoform X13"
                     /calculated_mol_wt=213032
     Region          <411..>543
                     /region_name="PRK10856"
                     /note="cytoskeleton protein RodZ"
                     /db_xref="CDD:236776"
     Region          570..642
                     /region_name="HAT_MBD"
                     /note="Methyl-CpG binding domains (MBD) present in
                     putative chromatin remodelling factor such as BAZ2A; BAZ2A
                     contains a MBD, DDT, PHD-type zinc finger and Bromo domain
                     suggesting that BAZ2A might be associated with histone
                     acetyltransferase (HAT) activity. The...; cd01397"
                     /db_xref="CDD:238691"
     Site            order(582,584,586,593,595,604,607,611)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238691"
     Region          867..932
                     /region_name="DDT"
                     /note="domain in different transcription and chromosome
                     remodeling factors; smart00571"
                     /db_xref="CDD:214726"
     Region          1130..>1185
                     /region_name="WSD"
                     /note="Williams-Beuren syndrome DDT (WSD), D-TOX E motif;
                     pfam15613"
                     /db_xref="CDD:464775"
     Region          <1346..1449
                     /region_name="PHA03378"
                     /note="EBNA-3B; Provisional"
                     /db_xref="CDD:223065"
     Region          <1458..1492
                     /region_name="WSD"
                     /note="Williams-Beuren syndrome DDT (WSD), D-TOX E motif;
                     pfam15613"
                     /db_xref="CDD:464775"
     Region          1697..1743
                     /region_name="PHD_BAZ2A"
                     /note="PHD finger found in bromodomain adjacent to zinc
                     finger domain protein 2A (BAZ2A); cd15629"
                     /db_xref="CDD:277099"
     Site            order(1704,1707..1708,1710..1714,1732..1735)
                     /site_type="other"
                     /note="H3 histone binding site [polypeptide binding]"
                     /db_xref="CDD:277099"
     Region          1816..1912
                     /region_name="Bromo_BAZ2A_B_like"
                     /note="Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo
                     adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were
                     identified as a novel human bromodomain gene by cDNA
                     library screening. BAZ2A is also known as Tip5
                     (Transcription termination factor I-interacting...;
                     cd05503"
                     /db_xref="CDD:99935"
     Site            order(1840,1845,1848,1887,1891,1897)
                     /site_type="active"
                     /note="acetyllysine binding site [active]"
                     /db_xref="CDD:99935"
     CDS             1..1923
                     /gene="BAZ2A"
                     /gene_synonym="TIP5; WALp3"
                     /coded_by="XM_054370880.1:372..6143"
                     /db_xref="GeneID:11176"
                     /db_xref="HGNC:HGNC:962"
                     /db_xref="MIM:605682"
ORIGIN      
        1 mevacilhtr ggvqktgerr emeandhfnf tglppapaas glkpspssge glytngspmn
       61 fpqqgkslng dvnvnglstv shtttsgiln saphssstsh lhhpsvaydc lwnysqypsa
      121 npgsnlkdpp llsqfsggqy plngilggsr qpsspshntn lragsqefwa ngtqspmgln
      181 fdsqelydsf pdqnfevmpn gppsfftspq tspmlgssiq tfapsqevgs gihpdeaaek
      241 emtsvvaeng tglvgslele eeqpelkmcg yngsvpsves lhqevsvlvp dptvsclddp
      301 shlpdqledt pilsedslep fnslapepvs gglygiddte lmgaedklpl edspvisald
      361 cpslnnataf slladdsqts tsifasptsp pvlgesvlqd nsfdlnngsd aeqeemetqs
      421 sdfppsltqp apdqsstiql hpatspavsp ttspavslvv spaaspeisp evcpaastvv
      481 spavfsvvsp assavlpavs levpltasvt spkaspvtsp aaafptaspa nkdvssflet
      541 tadveeitge gltasgsgdv mrrriatpee vrlplqhgwr revrikkgsh rwqgetwyyg
      601 pcgkrmkqfp evikylsrnv vhsvrrehfs fsprmpvgdf feerdtpegl qwvqlsaeei
      661 psriqaitgk rgrprnteka ktkevpkvkr grgrppkvki tellnktdnr plkkleaqet
      721 lneedkakia kskkkmrqkv qrgecqttiq gqarnkrkqe tkslkqkeak kkskaekekg
      781 ktkqeklkek vkrekkekvk mkekeevtka kpackadktl atqrrleerq rqqmileemk
      841 kptedmcltd hqplpdfsrv pgltlpsgaf sdcltivefl hsfgkvlgfd pakdvpslgv
      901 lqegllcqgd slgevqdllv rllkaalhdp gfpsycqslk ilgekvseip ltrdnvseil
      961 rcflmaygve palcdrlrtq pfqaqppqqk aavlaflvhe lngstliine idktlesmss
     1021 yrknkwiveg rlrrlktvla krtgrsevem egpeeclgrr rssrimeets gmeeeeeees
     1081 iaavpgrrgr rdgevdatas sipelerqie klskrqlffr kkllhssqml ravslgqdry
     1141 rrrywvlpyl agifvegteg nlvpeevikk etdslkvaah aslnpalfsm kmelagsntt
     1201 assparargr prktkpgsmq prhlkspvrg qdseqpqaql qpeaqlhapa qpqpqlqlql
     1261 qshkgfleqe gsplslgqsq hdlsqsafls wlsqtqshss llsssvltpd sspgkldpap
     1321 sqppeepepd eaesspdpqa lwfnisaqmp cnaaptpppa vsedqptpsp qqlasskpmn
     1381 rpsaanpcsp vqfsstplag lapkrragdp gempqsptgl gqpkrrgrpp skffkqmeqr
     1441 yltqltaqpv ppemcsgwww irdpemldam lkalhprgir ekalhkhlnk hrdflqevcl
     1501 rpsadpifep rqlpafqegi mswspkekty etdlavlqwv eeleqrvims dlqirgwtcp
     1561 spdstredla ycehlsdsqe ditwrgrgre glapqrkttn pldlavmrla aleqnverry
     1621 lreplwpthe vvlekallst pngapegttt eisyeitpri rvwrqtlerc rsaaqvclcl
     1681 gqlersiawe ksvnkvtclv crkgdndefl llcdgcdrgc hiychrpkme avpegdwfct
     1741 vclaqvegef tqkpgfpkrg qkrksgysln fsegdgrrrr vllrgrespa agpryseegl
     1801 spskrrrlsm rnhhsdltfc eiilmemesh daawpflepv nprlvsgyrr iiknpmdfst
     1861 mrerllrggy tsseefaada llvfdncqtf neddsevgka ghimrrffes rweefyqgkq
     1921 anl
//
LOCUS       XP_054226856            1923 aa            linear   PRI 05-AUG-2025
DEFINITION  bromodomain adjacent to zinc finger domain protein 2A isoform X13
            [Homo sapiens].
ACCESSION   XP_054226856
VERSION     XP_054226856.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370881.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1923
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1923
                     /product="bromodomain adjacent to zinc finger domain
                     protein 2A isoform X13"
                     /calculated_mol_wt=213032
     Region          <411..>543
                     /region_name="PRK10856"
                     /note="cytoskeleton protein RodZ"
                     /db_xref="CDD:236776"
     Region          570..642
                     /region_name="HAT_MBD"
                     /note="Methyl-CpG binding domains (MBD) present in
                     putative chromatin remodelling factor such as BAZ2A; BAZ2A
                     contains a MBD, DDT, PHD-type zinc finger and Bromo domain
                     suggesting that BAZ2A might be associated with histone
                     acetyltransferase (HAT) activity. The...; cd01397"
                     /db_xref="CDD:238691"
     Site            order(582,584,586,593,595,604,607,611)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238691"
     Region          867..932
                     /region_name="DDT"
                     /note="domain in different transcription and chromosome
                     remodeling factors; smart00571"
                     /db_xref="CDD:214726"
     Region          1130..>1185
                     /region_name="WSD"
                     /note="Williams-Beuren syndrome DDT (WSD), D-TOX E motif;
                     pfam15613"
                     /db_xref="CDD:464775"
     Region          <1346..1449
                     /region_name="PHA03378"
                     /note="EBNA-3B; Provisional"
                     /db_xref="CDD:223065"
     Region          <1458..1492
                     /region_name="WSD"
                     /note="Williams-Beuren syndrome DDT (WSD), D-TOX E motif;
                     pfam15613"
                     /db_xref="CDD:464775"
     Region          1697..1743
                     /region_name="PHD_BAZ2A"
                     /note="PHD finger found in bromodomain adjacent to zinc
                     finger domain protein 2A (BAZ2A); cd15629"
                     /db_xref="CDD:277099"
     Site            order(1704,1707..1708,1710..1714,1732..1735)
                     /site_type="other"
                     /note="H3 histone binding site [polypeptide binding]"
                     /db_xref="CDD:277099"
     Region          1816..1912
                     /region_name="Bromo_BAZ2A_B_like"
                     /note="Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo
                     adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were
                     identified as a novel human bromodomain gene by cDNA
                     library screening. BAZ2A is also known as Tip5
                     (Transcription termination factor I-interacting...;
                     cd05503"
                     /db_xref="CDD:99935"
     Site            order(1840,1845,1848,1887,1891,1897)
                     /site_type="active"
                     /note="acetyllysine binding site [active]"
                     /db_xref="CDD:99935"
     CDS             1..1923
                     /gene="BAZ2A"
                     /gene_synonym="TIP5; WALp3"
                     /coded_by="XM_054370881.1:306..6077"
                     /db_xref="GeneID:11176"
                     /db_xref="HGNC:HGNC:962"
                     /db_xref="MIM:605682"
ORIGIN      
        1 mevacilhtr ggvqktgerr emeandhfnf tglppapaas glkpspssge glytngspmn
       61 fpqqgkslng dvnvnglstv shtttsgiln saphssstsh lhhpsvaydc lwnysqypsa
      121 npgsnlkdpp llsqfsggqy plngilggsr qpsspshntn lragsqefwa ngtqspmgln
      181 fdsqelydsf pdqnfevmpn gppsfftspq tspmlgssiq tfapsqevgs gihpdeaaek
      241 emtsvvaeng tglvgslele eeqpelkmcg yngsvpsves lhqevsvlvp dptvsclddp
      301 shlpdqledt pilsedslep fnslapepvs gglygiddte lmgaedklpl edspvisald
      361 cpslnnataf slladdsqts tsifasptsp pvlgesvlqd nsfdlnngsd aeqeemetqs
      421 sdfppsltqp apdqsstiql hpatspavsp ttspavslvv spaaspeisp evcpaastvv
      481 spavfsvvsp assavlpavs levpltasvt spkaspvtsp aaafptaspa nkdvssflet
      541 tadveeitge gltasgsgdv mrrriatpee vrlplqhgwr revrikkgsh rwqgetwyyg
      601 pcgkrmkqfp evikylsrnv vhsvrrehfs fsprmpvgdf feerdtpegl qwvqlsaeei
      661 psriqaitgk rgrprnteka ktkevpkvkr grgrppkvki tellnktdnr plkkleaqet
      721 lneedkakia kskkkmrqkv qrgecqttiq gqarnkrkqe tkslkqkeak kkskaekekg
      781 ktkqeklkek vkrekkekvk mkekeevtka kpackadktl atqrrleerq rqqmileemk
      841 kptedmcltd hqplpdfsrv pgltlpsgaf sdcltivefl hsfgkvlgfd pakdvpslgv
      901 lqegllcqgd slgevqdllv rllkaalhdp gfpsycqslk ilgekvseip ltrdnvseil
      961 rcflmaygve palcdrlrtq pfqaqppqqk aavlaflvhe lngstliine idktlesmss
     1021 yrknkwiveg rlrrlktvla krtgrsevem egpeeclgrr rssrimeets gmeeeeeees
     1081 iaavpgrrgr rdgevdatas sipelerqie klskrqlffr kkllhssqml ravslgqdry
     1141 rrrywvlpyl agifvegteg nlvpeevikk etdslkvaah aslnpalfsm kmelagsntt
     1201 assparargr prktkpgsmq prhlkspvrg qdseqpqaql qpeaqlhapa qpqpqlqlql
     1261 qshkgfleqe gsplslgqsq hdlsqsafls wlsqtqshss llsssvltpd sspgkldpap
     1321 sqppeepepd eaesspdpqa lwfnisaqmp cnaaptpppa vsedqptpsp qqlasskpmn
     1381 rpsaanpcsp vqfsstplag lapkrragdp gempqsptgl gqpkrrgrpp skffkqmeqr
     1441 yltqltaqpv ppemcsgwww irdpemldam lkalhprgir ekalhkhlnk hrdflqevcl
     1501 rpsadpifep rqlpafqegi mswspkekty etdlavlqwv eeleqrvims dlqirgwtcp
     1561 spdstredla ycehlsdsqe ditwrgrgre glapqrkttn pldlavmrla aleqnverry
     1621 lreplwpthe vvlekallst pngapegttt eisyeitpri rvwrqtlerc rsaaqvclcl
     1681 gqlersiawe ksvnkvtclv crkgdndefl llcdgcdrgc hiychrpkme avpegdwfct
     1741 vclaqvegef tqkpgfpkrg qkrksgysln fsegdgrrrr vllrgrespa agpryseegl
     1801 spskrrrlsm rnhhsdltfc eiilmemesh daawpflepv nprlvsgyrr iiknpmdfst
     1861 mrerllrggy tsseefaada llvfdncqtf neddsevgka ghimrrffes rweefyqgkq
     1921 anl
//
LOCUS       XP_054226857            1910 aa            linear   PRI 05-AUG-2025
DEFINITION  bromodomain adjacent to zinc finger domain protein 2A isoform X2
            [Homo sapiens].
ACCESSION   XP_054226857
VERSION     XP_054226857.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370882.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1910
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1910
                     /product="bromodomain adjacent to zinc finger domain
                     protein 2A isoform X2"
                     /calculated_mol_wt=211532
     Region          <390..>522
                     /region_name="PRK10856"
                     /note="cytoskeleton protein RodZ"
                     /db_xref="CDD:236776"
     Region          549..621
                     /region_name="HAT_MBD"
                     /note="Methyl-CpG binding domains (MBD) present in
                     putative chromatin remodelling factor such as BAZ2A; BAZ2A
                     contains a MBD, DDT, PHD-type zinc finger and Bromo domain
                     suggesting that BAZ2A might be associated with histone
                     acetyltransferase (HAT) activity. The...; cd01397"
                     /db_xref="CDD:238691"
     Site            order(561,563,565,572,574,583,586,590)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238691"
     Region          846..911
                     /region_name="DDT"
                     /note="domain in different transcription and chromosome
                     remodeling factors; smart00571"
                     /db_xref="CDD:214726"
     Region          1109..>1164
                     /region_name="WSD"
                     /note="Williams-Beuren syndrome DDT (WSD), D-TOX E motif;
                     pfam15613"
                     /db_xref="CDD:464775"
     Region          <1325..1428
                     /region_name="PHA03378"
                     /note="EBNA-3B; Provisional"
                     /db_xref="CDD:223065"
     Region          <1437..1471
                     /region_name="WSD"
                     /note="Williams-Beuren syndrome DDT (WSD), D-TOX E motif;
                     pfam15613"
                     /db_xref="CDD:464775"
     Region          1683..1729
                     /region_name="PHD_BAZ2A"
                     /note="PHD finger found in bromodomain adjacent to zinc
                     finger domain protein 2A (BAZ2A); cd15629"
                     /db_xref="CDD:277099"
     Site            order(1690,1693..1694,1696..1700,1718..1721)
                     /site_type="other"
                     /note="H3 histone binding site [polypeptide binding]"
                     /db_xref="CDD:277099"
     Region          1803..1899
                     /region_name="Bromo_BAZ2A_B_like"
                     /note="Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo
                     adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were
                     identified as a novel human bromodomain gene by cDNA
                     library screening. BAZ2A is also known as Tip5
                     (Transcription termination factor I-interacting...;
                     cd05503"
                     /db_xref="CDD:99935"
     Site            order(1827,1832,1835,1874,1878,1884)
                     /site_type="active"
                     /note="acetyllysine binding site [active]"
                     /db_xref="CDD:99935"
     CDS             1..1910
                     /gene="BAZ2A"
                     /gene_synonym="TIP5; WALp3"
                     /coded_by="XM_054370882.1:105..5837"
                     /db_xref="GeneID:11176"
                     /db_xref="HGNC:HGNC:962"
                     /db_xref="MIM:605682"
ORIGIN      
        1 meandhfnft glppapaasg lkpspssgeg lytngspmnf pqqgkslngd vnvnglstvs
       61 htttsgilns aphssstshl hhpsvaydcl wnysqypsan pgsnlkdppl lsqfsggqyp
      121 lngilggsrq psspshntnl ragsqefwan gtqspmglnf dsqelydsfp dqnfevmpng
      181 ppsfftspqt spmlgssiqt fapsqevgsg ihpdeaaeke mtsvvaengt glvgslelee
      241 eqpelkmcgy ngsvpsvesl hqevsvlvpd ptvsclddps hlpdqledtp ilsedslepf
      301 nslapepvsg glygiddtel mgaedklple dspvisaldc pslnnatafs lladdsqtst
      361 sifasptspp vlgesvlqdn sfdlnngsda eqeemetqss dfppsltqpa pdqsstiqlh
      421 patspavspt tspavslvvs paaspeispe vcpaastvvs pavfsvvspa ssavlpavsl
      481 evpltasvts pkaspvtspa aafptaspan kdvssflett adveeitgeg ltasgsgdvm
      541 rrriatpeev rlplqhgwrr evrikkgshr wqgetwyygp cgkrmkqfpe vikylsrnvv
      601 hsvrrehfsf sprmpvgdff eerdtpeglq wvqlsaeeip sriqaitgkr grprntekak
      661 tkevpkvkrg rgrppkvkit ellnktdnrp lkkleaqetl needkakiak skkkmrqkvq
      721 rgecqttiqg qarnkrkqet kslkqkeakk kskaekekgk tkqeklkekv krekkekvkm
      781 kekeevtkak packadktla tqrrleerqr qqmileemkk ptedmcltdh qplpdfsrvp
      841 gltlpsgafs dcltiveflh sfgkvlgfdp akdvpslgvl qegllcqgds lgevqdllvr
      901 llkaalhdpg fpsycqslki lgekvseipl trdnvseilr cflmaygvep alcdrlrtqp
      961 fqaqppqqka avlaflvhel ngstliinei dktlesmssy rknkwivegr lrrlktvlak
     1021 rtgrseveme gpeeclgrrr ssrimeetsg meeeeeeesi aavpgrrgrr dgevdatass
     1081 ipelerqiek lskrqlffrk kllhssqmlr avslgqdryr rrywvlpyla gifvegtegn
     1141 lvpeevikke tdslkvaaha slnpalfsmk melagsntta ssparargrp rktkpgsmqp
     1201 rhlkspvrgq dseqpqaqlq peaqlhapaq pqpqlqlqlq shkgfleqeg splslgqsqh
     1261 dlsqsaflsw lsqtqshssl lsssvltpds spgkldpaps qppeepepde aesspdpqal
     1321 wfnisaqmpc naaptpppav sedqptpspq qlasskpmnr psaanpcspv qfsstplagl
     1381 apkrragdpg empqsptglg qpkrrgrpps kffkqmeqry ltqltaqpvp pemcsgwwwi
     1441 rdpemldaml kalhprgire kalhkhlnkh rdflqevclr psadpifepr qlpafqegim
     1501 swspkektye tdlavlqwve eleqrvimsd lqirgwtcps pdstredlay cehlsdsqed
     1561 itwrgrgreg lapqrkttnp ldlavmrlaa leqnverryl replwpthev vlekallstp
     1621 ngapegttte isplspsrsy eitprirvwr qtlercrsaa qvclclgqle rsiaweksvn
     1681 kvtclvcrkg dndeflllcd gcdrgchiyc hrpkmeavpe gdwfctvcla qqvegeftqk
     1741 pgfpkrgqkr ksgyslnfse gdgrrrrvll rgrespaagp ryseeglsps krrrlsmrnh
     1801 hsdltfceii lmemeshdaa wpflepvnpr lvsgyrriik npmdfstmre rllrggytss
     1861 eefaadallv fdncqtfned dsevgkaghi mrrffesrwe efyqgkqanl
//
LOCUS       XP_054226858            1910 aa            linear   PRI 05-AUG-2025
DEFINITION  bromodomain adjacent to zinc finger domain protein 2A isoform X2
            [Homo sapiens].
ACCESSION   XP_054226858
VERSION     XP_054226858.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370883.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1910
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1910
                     /product="bromodomain adjacent to zinc finger domain
                     protein 2A isoform X2"
                     /calculated_mol_wt=211532
     Region          <390..>522
                     /region_name="PRK10856"
                     /note="cytoskeleton protein RodZ"
                     /db_xref="CDD:236776"
     Region          549..621
                     /region_name="HAT_MBD"
                     /note="Methyl-CpG binding domains (MBD) present in
                     putative chromatin remodelling factor such as BAZ2A; BAZ2A
                     contains a MBD, DDT, PHD-type zinc finger and Bromo domain
                     suggesting that BAZ2A might be associated with histone
                     acetyltransferase (HAT) activity. The...; cd01397"
                     /db_xref="CDD:238691"
     Site            order(561,563,565,572,574,583,586,590)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238691"
     Region          846..911
                     /region_name="DDT"
                     /note="domain in different transcription and chromosome
                     remodeling factors; smart00571"
                     /db_xref="CDD:214726"
     Region          1109..>1164
                     /region_name="WSD"
                     /note="Williams-Beuren syndrome DDT (WSD), D-TOX E motif;
                     pfam15613"
                     /db_xref="CDD:464775"
     Region          <1325..1428
                     /region_name="PHA03378"
                     /note="EBNA-3B; Provisional"
                     /db_xref="CDD:223065"
     Region          <1437..1471
                     /region_name="WSD"
                     /note="Williams-Beuren syndrome DDT (WSD), D-TOX E motif;
                     pfam15613"
                     /db_xref="CDD:464775"
     Region          1683..1729
                     /region_name="PHD_BAZ2A"
                     /note="PHD finger found in bromodomain adjacent to zinc
                     finger domain protein 2A (BAZ2A); cd15629"
                     /db_xref="CDD:277099"
     Site            order(1690,1693..1694,1696..1700,1718..1721)
                     /site_type="other"
                     /note="H3 histone binding site [polypeptide binding]"
                     /db_xref="CDD:277099"
     Region          1803..1899
                     /region_name="Bromo_BAZ2A_B_like"
                     /note="Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo
                     adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were
                     identified as a novel human bromodomain gene by cDNA
                     library screening. BAZ2A is also known as Tip5
                     (Transcription termination factor I-interacting...;
                     cd05503"
                     /db_xref="CDD:99935"
     Site            order(1827,1832,1835,1874,1878,1884)
                     /site_type="active"
                     /note="acetyllysine binding site [active]"
                     /db_xref="CDD:99935"
     CDS             1..1910
                     /gene="BAZ2A"
                     /gene_synonym="TIP5; WALp3"
                     /coded_by="XM_054370883.1:271..6003"
                     /db_xref="GeneID:11176"
                     /db_xref="HGNC:HGNC:962"
                     /db_xref="MIM:605682"
ORIGIN      
        1 meandhfnft glppapaasg lkpspssgeg lytngspmnf pqqgkslngd vnvnglstvs
       61 htttsgilns aphssstshl hhpsvaydcl wnysqypsan pgsnlkdppl lsqfsggqyp
      121 lngilggsrq psspshntnl ragsqefwan gtqspmglnf dsqelydsfp dqnfevmpng
      181 ppsfftspqt spmlgssiqt fapsqevgsg ihpdeaaeke mtsvvaengt glvgslelee
      241 eqpelkmcgy ngsvpsvesl hqevsvlvpd ptvsclddps hlpdqledtp ilsedslepf
      301 nslapepvsg glygiddtel mgaedklple dspvisaldc pslnnatafs lladdsqtst
      361 sifasptspp vlgesvlqdn sfdlnngsda eqeemetqss dfppsltqpa pdqsstiqlh
      421 patspavspt tspavslvvs paaspeispe vcpaastvvs pavfsvvspa ssavlpavsl
      481 evpltasvts pkaspvtspa aafptaspan kdvssflett adveeitgeg ltasgsgdvm
      541 rrriatpeev rlplqhgwrr evrikkgshr wqgetwyygp cgkrmkqfpe vikylsrnvv
      601 hsvrrehfsf sprmpvgdff eerdtpeglq wvqlsaeeip sriqaitgkr grprntekak
      661 tkevpkvkrg rgrppkvkit ellnktdnrp lkkleaqetl needkakiak skkkmrqkvq
      721 rgecqttiqg qarnkrkqet kslkqkeakk kskaekekgk tkqeklkekv krekkekvkm
      781 kekeevtkak packadktla tqrrleerqr qqmileemkk ptedmcltdh qplpdfsrvp
      841 gltlpsgafs dcltiveflh sfgkvlgfdp akdvpslgvl qegllcqgds lgevqdllvr
      901 llkaalhdpg fpsycqslki lgekvseipl trdnvseilr cflmaygvep alcdrlrtqp
      961 fqaqppqqka avlaflvhel ngstliinei dktlesmssy rknkwivegr lrrlktvlak
     1021 rtgrseveme gpeeclgrrr ssrimeetsg meeeeeeesi aavpgrrgrr dgevdatass
     1081 ipelerqiek lskrqlffrk kllhssqmlr avslgqdryr rrywvlpyla gifvegtegn
     1141 lvpeevikke tdslkvaaha slnpalfsmk melagsntta ssparargrp rktkpgsmqp
     1201 rhlkspvrgq dseqpqaqlq peaqlhapaq pqpqlqlqlq shkgfleqeg splslgqsqh
     1261 dlsqsaflsw lsqtqshssl lsssvltpds spgkldpaps qppeepepde aesspdpqal
     1321 wfnisaqmpc naaptpppav sedqptpspq qlasskpmnr psaanpcspv qfsstplagl
     1381 apkrragdpg empqsptglg qpkrrgrpps kffkqmeqry ltqltaqpvp pemcsgwwwi
     1441 rdpemldaml kalhprgire kalhkhlnkh rdflqevclr psadpifepr qlpafqegim
     1501 swspkektye tdlavlqwve eleqrvimsd lqirgwtcps pdstredlay cehlsdsqed
     1561 itwrgrgreg lapqrkttnp ldlavmrlaa leqnverryl replwpthev vlekallstp
     1621 ngapegttte isplspsrsy eitprirvwr qtlercrsaa qvclclgqle rsiaweksvn
     1681 kvtclvcrkg dndeflllcd gcdrgchiyc hrpkmeavpe gdwfctvcla qqvegeftqk
     1741 pgfpkrgqkr ksgyslnfse gdgrrrrvll rgrespaagp ryseeglsps krrrlsmrnh
     1801 hsdltfceii lmemeshdaa wpflepvnpr lvsgyrriik npmdfstmre rllrggytss
     1861 eefaadallv fdncqtfned dsevgkaghi mrrffesrwe efyqgkqanl
//
LOCUS       XP_054226859            1910 aa            linear   PRI 05-AUG-2025
DEFINITION  bromodomain adjacent to zinc finger domain protein 2A isoform X2
            [Homo sapiens].
ACCESSION   XP_054226859
VERSION     XP_054226859.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370884.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1910
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1910
                     /product="bromodomain adjacent to zinc finger domain
                     protein 2A isoform X2"
                     /calculated_mol_wt=211532
     Region          <390..>522
                     /region_name="PRK10856"
                     /note="cytoskeleton protein RodZ"
                     /db_xref="CDD:236776"
     Region          549..621
                     /region_name="HAT_MBD"
                     /note="Methyl-CpG binding domains (MBD) present in
                     putative chromatin remodelling factor such as BAZ2A; BAZ2A
                     contains a MBD, DDT, PHD-type zinc finger and Bromo domain
                     suggesting that BAZ2A might be associated with histone
                     acetyltransferase (HAT) activity. The...; cd01397"
                     /db_xref="CDD:238691"
     Site            order(561,563,565,572,574,583,586,590)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238691"
     Region          846..911
                     /region_name="DDT"
                     /note="domain in different transcription and chromosome
                     remodeling factors; smart00571"
                     /db_xref="CDD:214726"
     Region          1109..>1164
                     /region_name="WSD"
                     /note="Williams-Beuren syndrome DDT (WSD), D-TOX E motif;
                     pfam15613"
                     /db_xref="CDD:464775"
     Region          <1325..1428
                     /region_name="PHA03378"
                     /note="EBNA-3B; Provisional"
                     /db_xref="CDD:223065"
     Region          <1437..1471
                     /region_name="WSD"
                     /note="Williams-Beuren syndrome DDT (WSD), D-TOX E motif;
                     pfam15613"
                     /db_xref="CDD:464775"
     Region          1683..1729
                     /region_name="PHD_BAZ2A"
                     /note="PHD finger found in bromodomain adjacent to zinc
                     finger domain protein 2A (BAZ2A); cd15629"
                     /db_xref="CDD:277099"
     Site            order(1690,1693..1694,1696..1700,1718..1721)
                     /site_type="other"
                     /note="H3 histone binding site [polypeptide binding]"
                     /db_xref="CDD:277099"
     Region          1803..1899
                     /region_name="Bromo_BAZ2A_B_like"
                     /note="Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo
                     adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were
                     identified as a novel human bromodomain gene by cDNA
                     library screening. BAZ2A is also known as Tip5
                     (Transcription termination factor I-interacting...;
                     cd05503"
                     /db_xref="CDD:99935"
     Site            order(1827,1832,1835,1874,1878,1884)
                     /site_type="active"
                     /note="acetyllysine binding site [active]"
                     /db_xref="CDD:99935"
     CDS             1..1910
                     /gene="BAZ2A"
                     /gene_synonym="TIP5; WALp3"
                     /coded_by="XM_054370884.1:369..6101"
                     /db_xref="GeneID:11176"
                     /db_xref="HGNC:HGNC:962"
                     /db_xref="MIM:605682"
ORIGIN      
        1 meandhfnft glppapaasg lkpspssgeg lytngspmnf pqqgkslngd vnvnglstvs
       61 htttsgilns aphssstshl hhpsvaydcl wnysqypsan pgsnlkdppl lsqfsggqyp
      121 lngilggsrq psspshntnl ragsqefwan gtqspmglnf dsqelydsfp dqnfevmpng
      181 ppsfftspqt spmlgssiqt fapsqevgsg ihpdeaaeke mtsvvaengt glvgslelee
      241 eqpelkmcgy ngsvpsvesl hqevsvlvpd ptvsclddps hlpdqledtp ilsedslepf
      301 nslapepvsg glygiddtel mgaedklple dspvisaldc pslnnatafs lladdsqtst
      361 sifasptspp vlgesvlqdn sfdlnngsda eqeemetqss dfppsltqpa pdqsstiqlh
      421 patspavspt tspavslvvs paaspeispe vcpaastvvs pavfsvvspa ssavlpavsl
      481 evpltasvts pkaspvtspa aafptaspan kdvssflett adveeitgeg ltasgsgdvm
      541 rrriatpeev rlplqhgwrr evrikkgshr wqgetwyygp cgkrmkqfpe vikylsrnvv
      601 hsvrrehfsf sprmpvgdff eerdtpeglq wvqlsaeeip sriqaitgkr grprntekak
      661 tkevpkvkrg rgrppkvkit ellnktdnrp lkkleaqetl needkakiak skkkmrqkvq
      721 rgecqttiqg qarnkrkqet kslkqkeakk kskaekekgk tkqeklkekv krekkekvkm
      781 kekeevtkak packadktla tqrrleerqr qqmileemkk ptedmcltdh qplpdfsrvp
      841 gltlpsgafs dcltiveflh sfgkvlgfdp akdvpslgvl qegllcqgds lgevqdllvr
      901 llkaalhdpg fpsycqslki lgekvseipl trdnvseilr cflmaygvep alcdrlrtqp
      961 fqaqppqqka avlaflvhel ngstliinei dktlesmssy rknkwivegr lrrlktvlak
     1021 rtgrseveme gpeeclgrrr ssrimeetsg meeeeeeesi aavpgrrgrr dgevdatass
     1081 ipelerqiek lskrqlffrk kllhssqmlr avslgqdryr rrywvlpyla gifvegtegn
     1141 lvpeevikke tdslkvaaha slnpalfsmk melagsntta ssparargrp rktkpgsmqp
     1201 rhlkspvrgq dseqpqaqlq peaqlhapaq pqpqlqlqlq shkgfleqeg splslgqsqh
     1261 dlsqsaflsw lsqtqshssl lsssvltpds spgkldpaps qppeepepde aesspdpqal
     1321 wfnisaqmpc naaptpppav sedqptpspq qlasskpmnr psaanpcspv qfsstplagl
     1381 apkrragdpg empqsptglg qpkrrgrpps kffkqmeqry ltqltaqpvp pemcsgwwwi
     1441 rdpemldaml kalhprgire kalhkhlnkh rdflqevclr psadpifepr qlpafqegim
     1501 swspkektye tdlavlqwve eleqrvimsd lqirgwtcps pdstredlay cehlsdsqed
     1561 itwrgrgreg lapqrkttnp ldlavmrlaa leqnverryl replwpthev vlekallstp
     1621 ngapegttte isplspsrsy eitprirvwr qtlercrsaa qvclclgqle rsiaweksvn
     1681 kvtclvcrkg dndeflllcd gcdrgchiyc hrpkmeavpe gdwfctvcla qqvegeftqk
     1741 pgfpkrgqkr ksgyslnfse gdgrrrrvll rgrespaagp ryseeglsps krrrlsmrnh
     1801 hsdltfceii lmemeshdaa wpflepvnpr lvsgyrriik npmdfstmre rllrggytss
     1861 eefaadallv fdncqtfned dsevgkaghi mrrffesrwe efyqgkqanl
//
LOCUS       XP_054226860            1910 aa            linear   PRI 05-AUG-2025
DEFINITION  bromodomain adjacent to zinc finger domain protein 2A isoform X2
            [Homo sapiens].
ACCESSION   XP_054226860
VERSION     XP_054226860.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370885.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1910
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1910
                     /product="bromodomain adjacent to zinc finger domain
                     protein 2A isoform X2"
                     /calculated_mol_wt=211532
     Region          <390..>522
                     /region_name="PRK10856"
                     /note="cytoskeleton protein RodZ"
                     /db_xref="CDD:236776"
     Region          549..621
                     /region_name="HAT_MBD"
                     /note="Methyl-CpG binding domains (MBD) present in
                     putative chromatin remodelling factor such as BAZ2A; BAZ2A
                     contains a MBD, DDT, PHD-type zinc finger and Bromo domain
                     suggesting that BAZ2A might be associated with histone
                     acetyltransferase (HAT) activity. The...; cd01397"
                     /db_xref="CDD:238691"
     Site            order(561,563,565,572,574,583,586,590)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238691"
     Region          846..911
                     /region_name="DDT"
                     /note="domain in different transcription and chromosome
                     remodeling factors; smart00571"
                     /db_xref="CDD:214726"
     Region          1109..>1164
                     /region_name="WSD"
                     /note="Williams-Beuren syndrome DDT (WSD), D-TOX E motif;
                     pfam15613"
                     /db_xref="CDD:464775"
     Region          <1325..1428
                     /region_name="PHA03378"
                     /note="EBNA-3B; Provisional"
                     /db_xref="CDD:223065"
     Region          <1437..1471
                     /region_name="WSD"
                     /note="Williams-Beuren syndrome DDT (WSD), D-TOX E motif;
                     pfam15613"
                     /db_xref="CDD:464775"
     Region          1683..1729
                     /region_name="PHD_BAZ2A"
                     /note="PHD finger found in bromodomain adjacent to zinc
                     finger domain protein 2A (BAZ2A); cd15629"
                     /db_xref="CDD:277099"
     Site            order(1690,1693..1694,1696..1700,1718..1721)
                     /site_type="other"
                     /note="H3 histone binding site [polypeptide binding]"
                     /db_xref="CDD:277099"
     Region          1803..1899
                     /region_name="Bromo_BAZ2A_B_like"
                     /note="Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo
                     adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were
                     identified as a novel human bromodomain gene by cDNA
                     library screening. BAZ2A is also known as Tip5
                     (Transcription termination factor I-interacting...;
                     cd05503"
                     /db_xref="CDD:99935"
     Site            order(1827,1832,1835,1874,1878,1884)
                     /site_type="active"
                     /note="acetyllysine binding site [active]"
                     /db_xref="CDD:99935"
     CDS             1..1910
                     /gene="BAZ2A"
                     /gene_synonym="TIP5; WALp3"
                     /coded_by="XM_054370885.1:126..5858"
                     /db_xref="GeneID:11176"
                     /db_xref="HGNC:HGNC:962"
                     /db_xref="MIM:605682"
ORIGIN      
        1 meandhfnft glppapaasg lkpspssgeg lytngspmnf pqqgkslngd vnvnglstvs
       61 htttsgilns aphssstshl hhpsvaydcl wnysqypsan pgsnlkdppl lsqfsggqyp
      121 lngilggsrq psspshntnl ragsqefwan gtqspmglnf dsqelydsfp dqnfevmpng
      181 ppsfftspqt spmlgssiqt fapsqevgsg ihpdeaaeke mtsvvaengt glvgslelee
      241 eqpelkmcgy ngsvpsvesl hqevsvlvpd ptvsclddps hlpdqledtp ilsedslepf
      301 nslapepvsg glygiddtel mgaedklple dspvisaldc pslnnatafs lladdsqtst
      361 sifasptspp vlgesvlqdn sfdlnngsda eqeemetqss dfppsltqpa pdqsstiqlh
      421 patspavspt tspavslvvs paaspeispe vcpaastvvs pavfsvvspa ssavlpavsl
      481 evpltasvts pkaspvtspa aafptaspan kdvssflett adveeitgeg ltasgsgdvm
      541 rrriatpeev rlplqhgwrr evrikkgshr wqgetwyygp cgkrmkqfpe vikylsrnvv
      601 hsvrrehfsf sprmpvgdff eerdtpeglq wvqlsaeeip sriqaitgkr grprntekak
      661 tkevpkvkrg rgrppkvkit ellnktdnrp lkkleaqetl needkakiak skkkmrqkvq
      721 rgecqttiqg qarnkrkqet kslkqkeakk kskaekekgk tkqeklkekv krekkekvkm
      781 kekeevtkak packadktla tqrrleerqr qqmileemkk ptedmcltdh qplpdfsrvp
      841 gltlpsgafs dcltiveflh sfgkvlgfdp akdvpslgvl qegllcqgds lgevqdllvr
      901 llkaalhdpg fpsycqslki lgekvseipl trdnvseilr cflmaygvep alcdrlrtqp
      961 fqaqppqqka avlaflvhel ngstliinei dktlesmssy rknkwivegr lrrlktvlak
     1021 rtgrseveme gpeeclgrrr ssrimeetsg meeeeeeesi aavpgrrgrr dgevdatass
     1081 ipelerqiek lskrqlffrk kllhssqmlr avslgqdryr rrywvlpyla gifvegtegn
     1141 lvpeevikke tdslkvaaha slnpalfsmk melagsntta ssparargrp rktkpgsmqp
     1201 rhlkspvrgq dseqpqaqlq peaqlhapaq pqpqlqlqlq shkgfleqeg splslgqsqh
     1261 dlsqsaflsw lsqtqshssl lsssvltpds spgkldpaps qppeepepde aesspdpqal
     1321 wfnisaqmpc naaptpppav sedqptpspq qlasskpmnr psaanpcspv qfsstplagl
     1381 apkrragdpg empqsptglg qpkrrgrpps kffkqmeqry ltqltaqpvp pemcsgwwwi
     1441 rdpemldaml kalhprgire kalhkhlnkh rdflqevclr psadpifepr qlpafqegim
     1501 swspkektye tdlavlqwve eleqrvimsd lqirgwtcps pdstredlay cehlsdsqed
     1561 itwrgrgreg lapqrkttnp ldlavmrlaa leqnverryl replwpthev vlekallstp
     1621 ngapegttte isplspsrsy eitprirvwr qtlercrsaa qvclclgqle rsiaweksvn
     1681 kvtclvcrkg dndeflllcd gcdrgchiyc hrpkmeavpe gdwfctvcla qqvegeftqk
     1741 pgfpkrgqkr ksgyslnfse gdgrrrrvll rgrespaagp ryseeglsps krrrlsmrnh
     1801 hsdltfceii lmemeshdaa wpflepvnpr lvsgyrriik npmdfstmre rllrggytss
     1861 eefaadallv fdncqtfned dsevgkaghi mrrffesrwe efyqgkqanl
//
LOCUS       XP_054226861            1910 aa            linear   PRI 05-AUG-2025
DEFINITION  bromodomain adjacent to zinc finger domain protein 2A isoform X2
            [Homo sapiens].
ACCESSION   XP_054226861
VERSION     XP_054226861.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370886.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1910
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1910
                     /product="bromodomain adjacent to zinc finger domain
                     protein 2A isoform X2"
                     /calculated_mol_wt=211532
     Region          <390..>522
                     /region_name="PRK10856"
                     /note="cytoskeleton protein RodZ"
                     /db_xref="CDD:236776"
     Region          549..621
                     /region_name="HAT_MBD"
                     /note="Methyl-CpG binding domains (MBD) present in
                     putative chromatin remodelling factor such as BAZ2A; BAZ2A
                     contains a MBD, DDT, PHD-type zinc finger and Bromo domain
                     suggesting that BAZ2A might be associated with histone
                     acetyltransferase (HAT) activity. The...; cd01397"
                     /db_xref="CDD:238691"
     Site            order(561,563,565,572,574,583,586,590)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238691"
     Region          846..911
                     /region_name="DDT"
                     /note="domain in different transcription and chromosome
                     remodeling factors; smart00571"
                     /db_xref="CDD:214726"
     Region          1109..>1164
                     /region_name="WSD"
                     /note="Williams-Beuren syndrome DDT (WSD), D-TOX E motif;
                     pfam15613"
                     /db_xref="CDD:464775"
     Region          <1325..1428
                     /region_name="PHA03378"
                     /note="EBNA-3B; Provisional"
                     /db_xref="CDD:223065"
     Region          <1437..1471
                     /region_name="WSD"
                     /note="Williams-Beuren syndrome DDT (WSD), D-TOX E motif;
                     pfam15613"
                     /db_xref="CDD:464775"
     Region          1683..1729
                     /region_name="PHD_BAZ2A"
                     /note="PHD finger found in bromodomain adjacent to zinc
                     finger domain protein 2A (BAZ2A); cd15629"
                     /db_xref="CDD:277099"
     Site            order(1690,1693..1694,1696..1700,1718..1721)
                     /site_type="other"
                     /note="H3 histone binding site [polypeptide binding]"
                     /db_xref="CDD:277099"
     Region          1803..1899
                     /region_name="Bromo_BAZ2A_B_like"
                     /note="Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo
                     adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were
                     identified as a novel human bromodomain gene by cDNA
                     library screening. BAZ2A is also known as Tip5
                     (Transcription termination factor I-interacting...;
                     cd05503"
                     /db_xref="CDD:99935"
     Site            order(1827,1832,1835,1874,1878,1884)
                     /site_type="active"
                     /note="acetyllysine binding site [active]"
                     /db_xref="CDD:99935"
     CDS             1..1910
                     /gene="BAZ2A"
                     /gene_synonym="TIP5; WALp3"
                     /coded_by="XM_054370886.1:279..6011"
                     /db_xref="GeneID:11176"
                     /db_xref="HGNC:HGNC:962"
                     /db_xref="MIM:605682"
ORIGIN      
        1 meandhfnft glppapaasg lkpspssgeg lytngspmnf pqqgkslngd vnvnglstvs
       61 htttsgilns aphssstshl hhpsvaydcl wnysqypsan pgsnlkdppl lsqfsggqyp
      121 lngilggsrq psspshntnl ragsqefwan gtqspmglnf dsqelydsfp dqnfevmpng
      181 ppsfftspqt spmlgssiqt fapsqevgsg ihpdeaaeke mtsvvaengt glvgslelee
      241 eqpelkmcgy ngsvpsvesl hqevsvlvpd ptvsclddps hlpdqledtp ilsedslepf
      301 nslapepvsg glygiddtel mgaedklple dspvisaldc pslnnatafs lladdsqtst
      361 sifasptspp vlgesvlqdn sfdlnngsda eqeemetqss dfppsltqpa pdqsstiqlh
      421 patspavspt tspavslvvs paaspeispe vcpaastvvs pavfsvvspa ssavlpavsl
      481 evpltasvts pkaspvtspa aafptaspan kdvssflett adveeitgeg ltasgsgdvm
      541 rrriatpeev rlplqhgwrr evrikkgshr wqgetwyygp cgkrmkqfpe vikylsrnvv
      601 hsvrrehfsf sprmpvgdff eerdtpeglq wvqlsaeeip sriqaitgkr grprntekak
      661 tkevpkvkrg rgrppkvkit ellnktdnrp lkkleaqetl needkakiak skkkmrqkvq
      721 rgecqttiqg qarnkrkqet kslkqkeakk kskaekekgk tkqeklkekv krekkekvkm
      781 kekeevtkak packadktla tqrrleerqr qqmileemkk ptedmcltdh qplpdfsrvp
      841 gltlpsgafs dcltiveflh sfgkvlgfdp akdvpslgvl qegllcqgds lgevqdllvr
      901 llkaalhdpg fpsycqslki lgekvseipl trdnvseilr cflmaygvep alcdrlrtqp
      961 fqaqppqqka avlaflvhel ngstliinei dktlesmssy rknkwivegr lrrlktvlak
     1021 rtgrseveme gpeeclgrrr ssrimeetsg meeeeeeesi aavpgrrgrr dgevdatass
     1081 ipelerqiek lskrqlffrk kllhssqmlr avslgqdryr rrywvlpyla gifvegtegn
     1141 lvpeevikke tdslkvaaha slnpalfsmk melagsntta ssparargrp rktkpgsmqp
     1201 rhlkspvrgq dseqpqaqlq peaqlhapaq pqpqlqlqlq shkgfleqeg splslgqsqh
     1261 dlsqsaflsw lsqtqshssl lsssvltpds spgkldpaps qppeepepde aesspdpqal
     1321 wfnisaqmpc naaptpppav sedqptpspq qlasskpmnr psaanpcspv qfsstplagl
     1381 apkrragdpg empqsptglg qpkrrgrpps kffkqmeqry ltqltaqpvp pemcsgwwwi
     1441 rdpemldaml kalhprgire kalhkhlnkh rdflqevclr psadpifepr qlpafqegim
     1501 swspkektye tdlavlqwve eleqrvimsd lqirgwtcps pdstredlay cehlsdsqed
     1561 itwrgrgreg lapqrkttnp ldlavmrlaa leqnverryl replwpthev vlekallstp
     1621 ngapegttte isplspsrsy eitprirvwr qtlercrsaa qvclclgqle rsiaweksvn
     1681 kvtclvcrkg dndeflllcd gcdrgchiyc hrpkmeavpe gdwfctvcla qqvegeftqk
     1741 pgfpkrgqkr ksgyslnfse gdgrrrrvll rgrespaagp ryseeglsps krrrlsmrnh
     1801 hsdltfceii lmemeshdaa wpflepvnpr lvsgyrriik npmdfstmre rllrggytss
     1861 eefaadallv fdncqtfned dsevgkaghi mrrffesrwe efyqgkqanl
//
LOCUS       XP_054226862            1910 aa            linear   PRI 05-AUG-2025
DEFINITION  bromodomain adjacent to zinc finger domain protein 2A isoform X2
            [Homo sapiens].
ACCESSION   XP_054226862
VERSION     XP_054226862.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370887.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1910
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1910
                     /product="bromodomain adjacent to zinc finger domain
                     protein 2A isoform X2"
                     /calculated_mol_wt=211532
     Region          <390..>522
                     /region_name="PRK10856"
                     /note="cytoskeleton protein RodZ"
                     /db_xref="CDD:236776"
     Region          549..621
                     /region_name="HAT_MBD"
                     /note="Methyl-CpG binding domains (MBD) present in
                     putative chromatin remodelling factor such as BAZ2A; BAZ2A
                     contains a MBD, DDT, PHD-type zinc finger and Bromo domain
                     suggesting that BAZ2A might be associated with histone
                     acetyltransferase (HAT) activity. The...; cd01397"
                     /db_xref="CDD:238691"
     Site            order(561,563,565,572,574,583,586,590)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238691"
     Region          846..911
                     /region_name="DDT"
                     /note="domain in different transcription and chromosome
                     remodeling factors; smart00571"
                     /db_xref="CDD:214726"
     Region          1109..>1164
                     /region_name="WSD"
                     /note="Williams-Beuren syndrome DDT (WSD), D-TOX E motif;
                     pfam15613"
                     /db_xref="CDD:464775"
     Region          <1325..1428
                     /region_name="PHA03378"
                     /note="EBNA-3B; Provisional"
                     /db_xref="CDD:223065"
     Region          <1437..1471
                     /region_name="WSD"
                     /note="Williams-Beuren syndrome DDT (WSD), D-TOX E motif;
                     pfam15613"
                     /db_xref="CDD:464775"
     Region          1683..1729
                     /region_name="PHD_BAZ2A"
                     /note="PHD finger found in bromodomain adjacent to zinc
                     finger domain protein 2A (BAZ2A); cd15629"
                     /db_xref="CDD:277099"
     Site            order(1690,1693..1694,1696..1700,1718..1721)
                     /site_type="other"
                     /note="H3 histone binding site [polypeptide binding]"
                     /db_xref="CDD:277099"
     Region          1803..1899
                     /region_name="Bromo_BAZ2A_B_like"
                     /note="Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo
                     adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were
                     identified as a novel human bromodomain gene by cDNA
                     library screening. BAZ2A is also known as Tip5
                     (Transcription termination factor I-interacting...;
                     cd05503"
                     /db_xref="CDD:99935"
     Site            order(1827,1832,1835,1874,1878,1884)
                     /site_type="active"
                     /note="acetyllysine binding site [active]"
                     /db_xref="CDD:99935"
     CDS             1..1910
                     /gene="BAZ2A"
                     /gene_synonym="TIP5; WALp3"
                     /coded_by="XM_054370887.1:303..6035"
                     /db_xref="GeneID:11176"
                     /db_xref="HGNC:HGNC:962"
                     /db_xref="MIM:605682"
ORIGIN      
        1 meandhfnft glppapaasg lkpspssgeg lytngspmnf pqqgkslngd vnvnglstvs
       61 htttsgilns aphssstshl hhpsvaydcl wnysqypsan pgsnlkdppl lsqfsggqyp
      121 lngilggsrq psspshntnl ragsqefwan gtqspmglnf dsqelydsfp dqnfevmpng
      181 ppsfftspqt spmlgssiqt fapsqevgsg ihpdeaaeke mtsvvaengt glvgslelee
      241 eqpelkmcgy ngsvpsvesl hqevsvlvpd ptvsclddps hlpdqledtp ilsedslepf
      301 nslapepvsg glygiddtel mgaedklple dspvisaldc pslnnatafs lladdsqtst
      361 sifasptspp vlgesvlqdn sfdlnngsda eqeemetqss dfppsltqpa pdqsstiqlh
      421 patspavspt tspavslvvs paaspeispe vcpaastvvs pavfsvvspa ssavlpavsl
      481 evpltasvts pkaspvtspa aafptaspan kdvssflett adveeitgeg ltasgsgdvm
      541 rrriatpeev rlplqhgwrr evrikkgshr wqgetwyygp cgkrmkqfpe vikylsrnvv
      601 hsvrrehfsf sprmpvgdff eerdtpeglq wvqlsaeeip sriqaitgkr grprntekak
      661 tkevpkvkrg rgrppkvkit ellnktdnrp lkkleaqetl needkakiak skkkmrqkvq
      721 rgecqttiqg qarnkrkqet kslkqkeakk kskaekekgk tkqeklkekv krekkekvkm
      781 kekeevtkak packadktla tqrrleerqr qqmileemkk ptedmcltdh qplpdfsrvp
      841 gltlpsgafs dcltiveflh sfgkvlgfdp akdvpslgvl qegllcqgds lgevqdllvr
      901 llkaalhdpg fpsycqslki lgekvseipl trdnvseilr cflmaygvep alcdrlrtqp
      961 fqaqppqqka avlaflvhel ngstliinei dktlesmssy rknkwivegr lrrlktvlak
     1021 rtgrseveme gpeeclgrrr ssrimeetsg meeeeeeesi aavpgrrgrr dgevdatass
     1081 ipelerqiek lskrqlffrk kllhssqmlr avslgqdryr rrywvlpyla gifvegtegn
     1141 lvpeevikke tdslkvaaha slnpalfsmk melagsntta ssparargrp rktkpgsmqp
     1201 rhlkspvrgq dseqpqaqlq peaqlhapaq pqpqlqlqlq shkgfleqeg splslgqsqh
     1261 dlsqsaflsw lsqtqshssl lsssvltpds spgkldpaps qppeepepde aesspdpqal
     1321 wfnisaqmpc naaptpppav sedqptpspq qlasskpmnr psaanpcspv qfsstplagl
     1381 apkrragdpg empqsptglg qpkrrgrpps kffkqmeqry ltqltaqpvp pemcsgwwwi
     1441 rdpemldaml kalhprgire kalhkhlnkh rdflqevclr psadpifepr qlpafqegim
     1501 swspkektye tdlavlqwve eleqrvimsd lqirgwtcps pdstredlay cehlsdsqed
     1561 itwrgrgreg lapqrkttnp ldlavmrlaa leqnverryl replwpthev vlekallstp
     1621 ngapegttte isplspsrsy eitprirvwr qtlercrsaa qvclclgqle rsiaweksvn
     1681 kvtclvcrkg dndeflllcd gcdrgchiyc hrpkmeavpe gdwfctvcla qqvegeftqk
     1741 pgfpkrgqkr ksgyslnfse gdgrrrrvll rgrespaagp ryseeglsps krrrlsmrnh
     1801 hsdltfceii lmemeshdaa wpflepvnpr lvsgyrriik npmdfstmre rllrggytss
     1861 eefaadallv fdncqtfned dsevgkaghi mrrffesrwe efyqgkqanl
//
LOCUS       XP_054226863            1910 aa            linear   PRI 05-AUG-2025
DEFINITION  bromodomain adjacent to zinc finger domain protein 2A isoform X2
            [Homo sapiens].
ACCESSION   XP_054226863
VERSION     XP_054226863.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370888.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1910
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     Protein         1..1910
                     /product="bromodomain adjacent to zinc finger domain
                     protein 2A isoform X2"
                     /calculated_mol_wt=211532
     Region          <390..>522
                     /region_name="PRK10856"
                     /note="cytoskeleton protein RodZ"
                     /db_xref="CDD:236776"
     Region          549..621
                     /region_name="HAT_MBD"
                     /note="Methyl-CpG binding domains (MBD) present in
                     putative chromatin remodelling factor such as BAZ2A; BAZ2A
                     contains a MBD, DDT, PHD-type zinc finger and Bromo domain
                     suggesting that BAZ2A might be associated with histone
                     acetyltransferase (HAT) activity. The...; cd01397"
                     /db_xref="CDD:238691"
     Site            order(561,563,565,572,574,583,586,590)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238691"
     Region          846..911
                     /region_name="DDT"
                     /note="domain in different transcription and chromosome
                     remodeling factors; smart00571"
                     /db_xref="CDD:214726"
     Region          1109..>1164
                     /region_name="WSD"
                     /note="Williams-Beuren syndrome DDT (WSD), D-TOX E motif;
                     pfam15613"
                     /db_xref="CDD:464775"
     Region          <1325..1428
                     /region_name="PHA03378"
                     /note="EBNA-3B; Provisional"
                     /db_xref="CDD:223065"
     Region          <1437..1471
                     /region_name="WSD"
                     /note="Williams-Beuren syndrome DDT (WSD), D-TOX E motif;
                     pfam15613"
                     /db_xref="CDD:464775"
     Region          1683..1729
                     /region_name="PHD_BAZ2A"
                     /note="PHD finger found in bromodomain adjacent to zinc
                     finger domain protein 2A (BAZ2A); cd15629"
                     /db_xref="CDD:277099"
     Site            order(1690,1693..1694,1696..1700,1718..1721)
                     /site_type="other"
                     /note="H3 histone binding site [polypeptide binding]"
                     /db_xref="CDD:277099"
     Region          1803..1899
                     /region_name="Bromo_BAZ2A_B_like"
                     /note="Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo
                     adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were
                     identified as a novel human bromodomain gene by cDNA
                     library screening. BAZ2A is also known as Tip5
                     (Transcription termination factor I-interacting...;
                     cd05503"
                     /db_xref="CDD:99935"
     Site            order(1827,1832,1835,1874,1878,1884)
                     /site_type="active"
                     /note="acetyllysine binding site [active]"
                     /db_xref="CDD:99935"
     CDS             1..1910
                     /gene="BAZ2A"
                     /gene_synonym="TIP5; WALp3"
                     /coded_by="XM_054370888.1:366..6098"
                     /db_xref="GeneID:11176"
                     /db_xref="HGNC:HGNC:962"
                     /db_xref="MIM:605682"
ORIGIN      
        1 meandhfnft glppapaasg lkpspssgeg lytngspmnf pqqgkslngd vnvnglstvs
       61 htttsgilns aphssstshl hhpsvaydcl wnysqypsan pgsnlkdppl lsqfsggqyp
      121 lngilggsrq psspshntnl ragsqefwan gtqspmglnf dsqelydsfp dqnfevmpng
      181 ppsfftspqt spmlgssiqt fapsqevgsg ihpdeaaeke mtsvvaengt glvgslelee
      241 eqpelkmcgy ngsvpsvesl hqevsvlvpd ptvsclddps hlpdqledtp ilsedslepf
      301 nslapepvsg glygiddtel mgaedklple dspvisaldc pslnnatafs lladdsqtst
      361 sifasptspp vlgesvlqdn sfdlnngsda eqeemetqss dfppsltqpa pdqsstiqlh
      421 patspavspt tspavslvvs paaspeispe vcpaastvvs pavfsvvspa ssavlpavsl
      481 evpltasvts pkaspvtspa aafptaspan kdvssflett adveeitgeg ltasgsgdvm
      541 rrriatpeev rlplqhgwrr evrikkgshr wqgetwyygp cgkrmkqfpe vikylsrnvv
      601 hsvrrehfsf sprmpvgdff eerdtpeglq wvqlsaeeip sriqaitgkr grprntekak
      661 tkevpkvkrg rgrppkvkit ellnktdnrp lkkleaqetl needkakiak skkkmrqkvq
      721 rgecqttiqg qarnkrkqet kslkqkeakk kskaekekgk tkqeklkekv krekkekvkm
      781 kekeevtkak packadktla tqrrleerqr qqmileemkk ptedmcltdh qplpdfsrvp
      841 gltlpsgafs dcltiveflh sfgkvlgfdp akdvpslgvl qegllcqgds lgevqdllvr
      901 llkaalhdpg fpsycqslki lgekvseipl trdnvseilr cflmaygvep alcdrlrtqp
      961 fqaqppqqka avlaflvhel ngstliinei dktlesmssy rknkwivegr lrrlktvlak
     1021 rtgrseveme gpeeclgrrr ssrimeetsg meeeeeeesi aavpgrrgrr dgevdatass
     1081 ipelerqiek lskrqlffrk kllhssqmlr avslgqdryr rrywvlpyla gifvegtegn
     1141 lvpeevikke tdslkvaaha slnpalfsmk melagsntta ssparargrp rktkpgsmqp
     1201 rhlkspvrgq dseqpqaqlq peaqlhapaq pqpqlqlqlq shkgfleqeg splslgqsqh
     1261 dlsqsaflsw lsqtqshssl lsssvltpds spgkldpaps qppeepepde aesspdpqal
     1321 wfnisaqmpc naaptpppav sedqptpspq qlasskpmnr psaanpcspv qfsstplagl
     1381 apkrragdpg empqsptglg qpkrrgrpps kffkqmeqry ltqltaqpvp pemcsgwwwi
     1441 rdpemldaml kalhprgire kalhkhlnkh rdflqevclr psadpifepr qlpafqegim
     1501 swspkektye tdlavlqwve eleqrvimsd lqirgwtcps pdstredlay cehlsdsqed
     1561 itwrgrgreg lapqrkttnp ldlavmrlaa leqnverryl replwpthev vlekallstp
     1621 ngapegttte isplspsrsy eitprirvwr qtlercrsaa qvclclgqle rsiaweksvn
     1681 kvtclvcrkg dndeflllcd gcdrgchiyc hrpkmeavpe gdwfctvcla qqvegeftqk
     1741 pgfpkrgqkr ksgyslnfse gdgrrrrvll rgrespaagp ryseeglsps krrrlsmrnh
     1801 hsdltfceii lmemeshdaa wpflepvnpr lvsgyrriik npmdfstmre rllrggytss
     1861 eefaadallv fdncqtfned dsevgkaghi mrrffesrwe efyqgkqanl
//
LOCUS       XP_054226864            1903 aa            linear   PRI 05-AUG-2025
DEFINITION  bromodomain adjacent to zinc finger domain protein 2A isoform X5
            [Homo sapiens].
ACCESSION   XP_054226864
VERSION     XP_054226864.1
DBLINK      BioProject: PRJNA807723
DBSOURCE    REFSEQ: accession XM_054370889.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060936) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1903
                     /organism="Homo sapiens"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /se
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